bluuebunny/crossref_metadata_2025 huggingface dataset:
A Rare Case of Juvenile Systemic Sclerosis: Clinical Challenges and Management
Authors: Bano Areej , Verma Shalini , Bhatnagar Shrish
Published: February 2025

Scleroderma is “skleros” sclerosing or hardening of the “derma” skin. It includes both systemic and localized scleroderma (LS). Mostly, juvenile LS affects the skin, whereas juvenile systemic sclerosis (SSc) involves multiple organ systems. Localized type is the most common in juvenile populations (>95%), whereas SSc is associated with mortality and severe multiorgan morbidity. Here, we present a rare pediatric case of juvenile SSc exhibiting classical features of skin thickening, autoantibody positivity, and systemic involvement, emphasizing this condition’s rarity and clinical significance. Early recognition and multidisciplinary care are pivotal in improving outcomes, particularly in the pediatric population where systemic involvement can severely impact the quality of life and prognosis.
Splenic Calcifications in a Patient with Systemic Lupus Erythematosus: A Case Report
Authors: Al Arfaj Abdurhman Saud , Khalil Najma
Published: February 2025

Splenic calcifications are very rarely reported in systemic lupus erythematosus (SLE), a multisystem autoimmune disease. We report a 52-year-old woman having SLE, diagnosed in 1992, with lupus nephritis class IV/V treated with prednisolone, hydroxychloroquine, mycophenolate mofetil, and rituximab. A computed tomography scan of her abdomen and pelvis done in 2019, postdiagnosis of breast carcinoma showed incidental findings of innumerable tiny uniform benign calcifications in the spleen. Follow-up imaging tests of the abdomen and pelvis done until 2024 showed unchanged small scattered calcifications in the spleen. As in our case, splenic calcifications in SLE show a distinctive well-defined pattern of circular dense calcification, which excludes the capsular tissue unlike in other connective tissue diseases, are bigger than the punctate calcifications observed in granulomatous infections and are different in size and imaging appearance from splenic calcified metastases. Our case is one of the few case reports describing the rare feature of characteristic splenic calcifications in SLE.
Diagnostic Delay in Rheumatoid Arthritis Patients: A Multi-centric Study Conducted in Saudi Arabia
Authors: Alanazi Fehaid , Abdulaziz Sultana , Alghanim Khawla , Alhamzi Hanan , Alrayes Hanan
Published: February 2025

Background:

Early referral and treatment during the initial inflammatory stages of rheumatoid arthritis (RA) improve patient outcomes and quality of life. However, patients often delay seeking medical advice, leading to diagnostic delays. Limited data is available on diagnostic delays among RA patients in Saudi Arabia (SA).

Objectives:

This study evaluates the time lag between symptom onset, seeking medical advice, and diagnostic delay in RA patients registered in the Saudi Arthritis Registry (SAR).

Methods:

A retrospective multicenter study was conducted across five hospitals in Saudi Arabia, involving 668 RA patients aged 16 years and above who met the 2010 American College of Rheumatology/European League Against Rheumatism diagnostic criteria. Patients with other rheumatic diseases were excluded. Data on demographics, family history, symptom onset, healthcare visits, and diagnostic delays were extracted from the SAR. Analysis was performed using IBM SPSS version 28.

Results:

Among the 668 patients (569 women, 99 men; female-to-male ratio: 5.7:1), the median age was 43 years, and 59% were employed. Educational levels varied, with 20.36% illiterate, 24.9% with primary education, 25.7% high school, 27.1% bachelor’s, and 1.9% with advanced degrees. Delays in seeking medical advice were observed in 53% of patients (>6 months), 24.7% (3–5 months), and 22.3% (<3 months). Before rheumatology referral, 40.87% were seen by one healthcare provider, 35.48% by two, and 23.65% by three or more providers. General practitioners accounted for 27.1% of referrals. The median diagnostic delay was 16.42 weeks. Significant associations were observed between education, gender, and delays. Patients with higher education (Master’s/PhD) showed the highest prevalence of delay (72.6%, p < 0.001). Female patients tended to seek medical advice earlier (1–5 months, 49%) compared to males (3–11 months, 47.5%, p = 0.012). No significant associations were found between age, family history, and delays in seeking medical advice.

Conclusion:

Delays in seeking medical advice and diagnosis of RA were identified at multiple stages. Female patients sought care earlier than males, while higher educational attainment was paradoxically associated with greater delays. Early referral and timely treatment initiation by rheumatologists are essential to improve RA outcomes in Saudi Arabia.
Perioperative 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) regimen in gastric cancer: Pathological regression grade and its relationship to clinical outcome
Authors: Atci Muhammed M. , Secmeler Saban , Sakin Abdullah , Arici Serdar , Can Orcun , Selvi Oguzhan , Cekin Ruhper , Yasar Nurgul , Geredeli Caglayan , Cihan Sener
Published: February 2025

Background:

We aimed to evaluate the data of perioperative 5-fluorouracil, leucovorin, oxaliplatin, and docetaxel (FLOT) chemotherapy regimen in locally advanced gastric cancer (LAGC) patients with real-life experience.

Methods:

In this retrospective study, LAGC patients who received perioperative FLOT chemotherapy regimen between 2017 and 2020 were included. The patients were grouped according to tumor regression grade (TRG): histopathological responders (complete/moderate response) and histopathological non-responders (minimal/poor response). The factors affecting TRG were evaluated and its relationship to clinical outcome was analyzed by disease-free survival (DFS) and overall survival (OS).

Results:

A total of 141 LAGC patients were included. Median age of patients was 62 (range: 35–75) years of whom 69.5% were men. According to TRG, 41 (29.1%) patients were histopathological responders (College of American Pathologists (CAP)-TRG 0/1). Grade, perineural and lymphovascular invasion, clinical stage, tumor markers (Carcinoembryonic antigen (CEA) and Carbohydrate antigen (CA)19-9), radiological response, and ypTNM stage were statistically significant in univariate analysis and lymphovascular invasion was detected as an independent factor in multivariate analysis for TRG. Grade 3-4 toxicities were observed in only 28 (19.9%) patients. Two years DFS and OS rates were higher in the histopathological responder group (100% and 100%) compared to the histopathological non-responder group (59% and 52.9%) (P = 0.01 and P = 0.02, respectively).

Conclusion:

In our study, it was found that the FLOT regimen had a favorable TRG and a safe toxicity profile in gastric cancer patients. In addition, while lymphovascular invasion could predict TRG, the survival and disease recurrence were positively affected by the favorable TRG response.
Chronic myeloid leukemia during pregnancy complicated by dengue infection and pulmonary embolism
Authors: Wickramasinghe Wasanthi , Weerawardena Anoma , Ranaweera Prabhodhana , Gooneratne Lallindra , Wijeyaratne Chandrika
Published: February 2025

Chronic myeloid leukemia (CML) is a myeloproliferative neoplasm characterized by the rearrangement of long arm of chromosomes 9 and 22, resulting in the Philadelphia chromosome, creating the fusion oncogene BCR–ABL1. Median age of onset of CML is 67 years. However, approximately a third of patients are of reproductive age at diagnosis. CML presenting during pregnancy is extremely rare, and there are no randomized controlled trials to address the optimal management of CML during pregnancy. We report a 38-year-old woman diagnosed with CML during her routine antenatal clinic booking visit, which was further complicated by dengue fever and pulmonary embolism during pregnancy. She was successfully managed by a multidisciplinary team, which resulted in the delivery of a healthy baby boy. This case adds to the literature on CML in pregnancy and reflects the importance of a multidisciplinary team approach when managing complicated patients who require timely rational interventions.
A retrospective analysis of 26 cases of duodenal neuroendocrine tumor treated by endoscopic submucosal dissection
Authors: Li Kehan , Chen Tao , Duan Bensong , Ji Yingjie , Li Jingze , Xu Meidong
Published: February 2025

Background:

Duodenal neuroendocrine tumors (D-NETs) are rare but clinically significant tumors that can occur in various parts of the duodenum, including the duodenal papilla. Endoscopic submucosal dissection (ESD) has emerged as a minimally invasive treatment option for D-NETs, offering potential advantages in terms of tumor removal and postoperative recovery. We aimed to retrospectively analyze the clinical characteristics and prognosis of ESD for D-NETs.

Methods:

A total of 26 cases of duodenal neuroendocrine tumors (27 lesions), including duodenal papillary neuroendocrine tumors, were studied retrospectively.

Results:

A total of 26 patients with D-NETs (27 lesions) were pathologically diagnosed, and 27 lesions were found by chance during endoscopy. The lesions included duodenal bulbar, descending part, and duodenal papilla. Nineteen tumors were <1 cm (70.4%) in diameter, and eight tumors were 1–2 cm (29.6%) in diameter. There were five cases of duodenal papilla NETs. G1: 24 (88.8%) and G2: 3 (11.1%). Endoscopic ultrasonography showed that 27 lesions were confined to the submucosa. One case was a neuroendocrine tumor 2 mm inside a tubular adenoma at the papilla. All operations were performed by senior doctors in the department. The total resection rate was 100%, and the incidence of intraoperative bleeding and perforation was 0. Delayed bleeding and perforation were 0. The shortest operation time was 25 min, and the longest was 70 min. Burning tumor cells at the basal resection margin were noted in 11 lesions, necessitating careful pathological assessment. There were 24 cases of G1 type and 3 cases of G2 type. All 26 patients underwent abdominal CT before operation to confirm the absence of lymph node and distal metastasis. One patient with papillary lesion had positive lesion base resection and was treated with additional operation. Temporary biliary and pancreatic duct stents were placed before or after ESD in all five cases of duodenal papillary lesions, and no biliary and pancreatic complications occurred after surgery. Postoperative follow-up gastroscopy and abdominal CT confirmed no recurrence or metastasis during a follow-up period of 3 months to 4.5 years. There was no recurrence or metastasis during a follow-up period of 3 months to 4 ½ years.

Conclusion:

ESD may be an effective and safe intervention for D-NETs ≤20 mm confined to the mucosa or submucosa of the duodenum, including the papilla. Clinicians should remain vigilant about potential complications during and after surgery. Duodenal ESD treatment NET has high requirements in terms of treatment technology, and clinicians should pay attention to the potential complications of ESD during operation.
High-risk human papillomavirus infection among women with atypical squamous cells of undetermined significance in Pap smear: A seven-year follow-up study in South India
Authors: Kalavathy M.C. , Mathew Aleyamma , Krishna K.M. Jagathnath , Saritha V.N. , Sujathan K.
Published: February 2025

Background:

Well-defined pre-cancerous stages help early detection of uterine cervical cancer by Pap smear or human papillomavirus (HPV) analysis. HPV induces atypical squamous cells of undetermined significance (ASCUS) which can progress to higher grade lesions depending on persistence of infection with High-risk human papillomavirus (HrHPV). The HrHPV prevalence and persistence after 18–36 months, associated risk factors for persistence among women with ASCUS, and the effect of persisting HrHPV in the cytological progression upto a period of seven years are analyzed.

Methods:

In the routine Pap smear clinic of a Women and Children Hospital, women who had ASCUS in Pap smear in 2009–2011 were the sample for the study. A sample of 152 women with ASCUS in Pap smear, were subjected for HrHPV (16, 18, 31, 33 and 42) analysis. These women were invited for a repeat Pap smear and HrHPV analysis after 18 months. Women with HrHPV in both the rounds were advised to come for yearly routine follow-up Pap smear upto seven years.

Results:

The HrHPV prevalence was 46%, HrHPV persistence within 18–36 months was 60.8% and clearance was 39%. Among many risk factors for HrHPV persistence in univariate analysis, having more than two pregnancies and unhealthy appearing cervix were significant in multivariate analysis. 94% of the women with persistent ASCUS or higher lesion within seven years were initially persistent HrHPV positives.

Conclusion:

Since persistence of HrHPV in the cervix at least for 2 years helps in the persistence or progression of ASCUS even after seven years, routine HPV analysis should be done for women with ASCUS cytology, and who have high parity and unhealthy cervix. These women should be closely followed up to identify the progression to higher grade lesions.
Prospective assessment of quality of life in patients with brain metastasis receiving whole brain radiotherapy
Authors: Padhi Sanjukta , Meher Papuji , Pujari Lincoln , Mekap Himanshu Shekhar , Patro Kanhu C.
Published: February 2025

Background:

Palliative whole brain radiotherapy (WBRT) is an important cornerstone for the management of brain metastasis. WBRT alleviates symptoms, aiding in tapering of steroid dose. Thus, the assessment of quality of life (QoL) has become increasingly recognized as an important outcome in patients with brain metastasis. The primary objective of this study was to assess whether there was an improvement in QoL for patients with brain metastasis after radiation therapy and to evaluate the feasibility of application of shorter QoL assessment methods.

Methods:

This prospective observational study included 84 patients treated for brain metastasis. QoL assessments were conducted at baseline and three months after completion of WBRT. QoL assessment was done with EORTC QOL-C15-PAL, EORTC QOL-BN20 module and Barthel index for Activities of Daily Living. Statistical analysis was done using SPSS version 21, paired sample t-tests and Spearman’s correlation.

Results:

The median age was 59 years (range 37–81 years). Statistically significant improvement was seen in Barthel index at three months follow-up. For C-15-PAL and BN20 questionnaires, there was a statistically significant improvement seen in the majority of post therapy QoL scores. Baseline KPS was positively correlated with baseline Barthel index, C-15PAL physical functioning scale and baseline global QoL scale, but it negatively correlated with baseline QLQ-BN20 motor dysfunction scale. Baseline KPS was positively correlated with follow-up QLQ-C15-PAL physical functioning scale.

Conclusion:

Palliative therapy with WBRT for brain metastasis forms an integral support for improved quality of life. Among various assessment tools available, the shorter versions allow for better completion and compliance.
Pattern of distress among cancer patients assessed during new patient counseling: A cross-sectional study
Authors: Balasubramanian Satheesan , Abraham Jisha , Sobhith V K , Malodan Riyas
Published: February 2025

Background:

Distress is an unpleasant emotional feeling of uneasiness, sadness, worry, anger, helplessness, or guilt and is considered as the sixth vital sign of cancer. Understanding and managing distress at an early stage helps the patient to deal with cancer in a better way. The objective of the study is to estimate the pattern of distress among cancer patients assessed during new patient counseling and its association with demographic factors.

Methods:

This is a cross-sectional retrospective study conducted by reviewing the case record forms of patients for a period of 4 months. The study included cancer patients between the age of 18 and 75 who attended new patient counseling and reported a score on the NCCN distress thermometer. Those with incomplete information and history of known psychiatric or neurological disorders were excluded.

Results:

Among the 348 patients, 39.9% had a distress score of 4 or above, which is clinically significant distress. Nearly 75% of them reported that their distress has a psycho-social reason, and 25% reported that distress is due to physical reasons. Analysis of the association of gender and age with clinically significant distress revealed that women and younger age groups had higher distress. In our study, Christians had a higher association with clinically significant distress.

Conclusion:

More than one-third of the patients reported to have clinically significant distress. This emphasizes the key role of distress screening and new patient counseling in an oncology setting. This also stresses the need for a psychotherapeutic approach in managing psycho-social concerns of cancer patients.
Comparative Assessment of Stress and Anxiety among Medical and Nonmedical Undergraduate Students – A Cross-sectional Study
Authors: Mittal Nehal , Tyagi Niharika , Parvaiz Nida , Dhalla Nipun , Asthana Garima
Published: February 2025

Background:

In this increasing world of competition, the levels of stress, anxiety, and depression are increasing proportionately with the work pressures leaving a deep negative impact on the life of an individual. Therefore, this study aims to compare the stress and anxiety levels among medical and nonmedical students.

Methodology:

This cross-sectional study was conducted on 262 subjects aged between 19 and 25 years for a period of 6 months (January 2024 to June 2024). The recruited subjects constituted two groups: Group I of dental students (n = 131) and Group II of engineering students (n = 131). All the participants were made to fill out a Google Forms that consisted of the Work Stress Questionnaire (WSQ) and Hamilton Anxiety Rating Scale (HAM-A) to assess the stress levels. The obtained data were subjected to statistical analysis using SPSS version 24, and P < 0.05 was considered statistically significant with a power of 80%.

Results:

The results concluded that the prevalence of anxiety in medical students was relatively higher in Group I as compared to Group II on the basis of WSQ and HAM-A scales. On the basis of WSQ and HAM-A scales it was concluded that anxiety was relatively higher in Group I as compared to Group II, though the results were not statistically significant . Group 1 displayed mild anxiety in 24.4% of the participants, mild-to-moderate anxiety in 19.1% , moderate-to-severe anxiety in 24.4%, and severe anxiety in 35.9% individuals. These values were comparatively higher as compared to Group II where severe anxiety was found in 33.6% individuals.

Conclusion:

It was concluded that stress and anxiety were present in all the participants of both the groups, though slightly higher in medical students.
Cognitive Impairment amongst Older Adults with Chronic Medical Conditions and Its Association with Medication Adherence in a Nigerian Tertiary Hospital
Authors: Kareem Yesiru Adeyemi , Adesina Ismail Olaiitan , Olajide Abayomi O. , Shuaib Abdulhakeem , Ibrahim A.M. , Ogualili Placidus Nwakuba , Uwakwe Richard
Published: February 2025

Introduction:

Older adults constitute a rapidly growing population whose healthcare needs are unique, with a higher prevalence of physical and psychiatric morbidities. A knowledge gap exists on the association between cognitive impairment and medication adherence in older adults with chronic medical conditions. This study examined the association between cognitive impairment and medication adherence amongst older adults with hypertension, diabetes mellitus and arthritis.

Methods:

A cross-sectional study design was utilised. Three hundred and twenty-seven older adults aged 60 and above were recruited for six months. The socio-clinical pro forma, Community Screening Instrument for Dementia (CSID) and Morisky Medication Adherence Scale-8 were administered. A simple linear regression analysis was done to assess the relationship between medication adherence and cognitive impairment, whereas multiple linear regression was used to control for the effect of confounders on this association.

Results:

This study found a positive correlation between cognitive functioning and medication adherence, this, however, did not reach statistical significance (β =0.055, P = 0.318). The age of participants, number of medications, duration of illness and number of previous hospitalisations were identified as confounders in the effect of cognitive functioning on medication adherence. The model explained 6.3% of the variance in medication adherence. Using the general linear model, cognitive impairment and diagnosis of medical condition independently predicted medication adherence (P = 0.026 and P < 0.001, respectively). However, their interaction did not significantly influence medication adherence (P = 0.311).

Conclusion:

Cognitive impairment is associated with low medication adherence in older adults with chronic medical conditions. This association is affected by age, chronicity and admissions. This underscores the need for proactive screening of older adults in day-to-day geriatric practice.
TINJAUAN SISTEMATIS LITERATUR REVIEW: OPTIMALISASI PEMBELAJARAN MATEMATIKA MELALUI INTEGRASI TEKNOLOGI WEBSITE
Authors: Saputra Ivan Dwi , Subekti Fitrianto Eko
Published: February 2025

Studi ini menyelidiki penggunaan teknologi website dalam meningkatkan kualitas pembelajaran matematika secara online melalui pendekatan Tinjauan Sistematis Literatur (SLR). Penelitian ini mengumpulkan dan mengevaluasi 30 artikel terkini dari Google Scholar dan Mendeley yang dipublikasikan antara 2020 hingga 2024. Analisis SLR dilakukan untuk mengidentifikasi manfaat integrasi website dalam pembelajaran matematika. Hasilnya menunjukkan bahwa penggunaan website seperti Liveworksheets, Google Sites, dan Quizizz berkontribusi atas meningkatnya keterlibatan siswa di Sekolah Dasar dan Menengah. Di tingkat SMP, e-learning melalui website dan aplikasi Android meningkatkan kemandirian siswa, sementara video pembelajaran dan website khusus membantu meningkatkan motivasi belajr siswa. Di SMA dan Perguruan Tinggi, website pembelajaran matematika berdampak positif terhadap hasil akademik dan aktivitas belajar siswa. Meskipun terdapat beberapa kendala, penggunaan Google Sites dan Sistem Manajemen Pembelajaran (LMS) selama pandemi menunjukkan hasil yang menggembirakan. Secara keseluruhan, integrasi website dalam pembelajaran matematika memberikan manfaat yang signifikan dalam meningkatkan hasil belajar, motivasi, dan keterlibatan siswa di semua tingkatan pendidikan.AbstractThis study uses a Systematic Literature Review (SLR) methodology to examine how website technology can enhance online mathematics instruction. 31 current publications from Mendeley and Google Scholar that were published between 2020 and 2024 are gathered and assessed in this study. To determine the advantages of website integration in mathematics education, SLR analysis was done. According to the findings, using websites like Quizizz, Google Sites, and Liveworksheets helps raise student involvement in primary and intermediate schools. Learning videos and specialized websites assist boost motivation, but e-learning through websites and Android applications enhances student independence at the junior high school level. Websites that teach mathematics have a good effect on students' academic performance and learning activities in high schools and colleges. The usage of learning management systems (LMS) and Google Sites throughout the pandemic has shown excellent outcomes despite a number of challenges. All things considered, website integration in mathematics instruction has a considerable positive impact on student engagement, motivation, and learning outcomes at all educational levels.
Derebaşı (Kaçkar Dağı) Kaya Buzulunun Jeomorfolojisi Ve Kinematik Özellikleri
Authors: Yeşilyurt Serdar
Published: February 2025

Kaya buzulları, yüksek dağlık ortamlarda önemli periglasyal yer şekilleri olup, permafrost dağılımının ve iklim değişikliğinin etkilerinin belirlenmesinde kritik göstergelerden biridir. Bu çalışma, Türkiye’nin en geniş periglasyal alanlarından biri olan Kaçkar Dağları’ndaki Derebaşı Kaya Buzulu’nun jeomorfolojik özelliklerini ve kinematik davranışlarını incelemektedir. GNSS destekli İHA fotogrametrisi kullanılarak yüksek çözünürlüklü Sayısal Yüzey Modelleri (SYM) ve ortofotolar üretilmiş ve 2023-2024 yılları arasındaki yıllık hareket, yüzey deformasyonu ve aktivite durumu analiz edilmiştir. Bulgular, Derebaşı Kaya Buzulu’nun aktif, inaktif ve relikt bölümler içeren karmaşık bir morfolojiye sahip olduğunu ve hem glasyal (buz çekirdekli) hem de periglasyal (permafrost) süreçler tarafından şekillendiğini göstermektedir. Kaya buzulunun 3. lobu (LB3), yıllık maksimum 60 cm yatay hareket hızıyla en aktif bölüm olarak belirlenirken, LB1’in cephe kısmı bitki örtüsü ve durağan topoğrafyası ile relikt kaya buzulu karakteri sergilemektedir. LB1’in orta bölümü, derin sırt-oluk yapılarıyla permafrost hareketinin izlerini taşırken, LB3’ün dışbükey gövde yapısı ve düzgün yüzeyi buz çekirdeğinin varlığına işaret etmektedir. Kinematik analizler, topoğrafik kısıtlamalar ve döküntü beslenmesi ile şekillenen heterojen hareket paternlerini ortaya koymuştur. LB1’de sıkıştırmalı akışa bağlı deformasyon yapıları gözlenirken, LB3’te gerilmeli deformasyon desenleri belirlenmiştir. Çalışmada ayrıca bölgedeki dağ permafrostunun güncel alt sınırının yaklaşık 2900 m olduğu hesaplanmıştır. Tespit edilen hareketler permafrost istikrarsızlığına işaret etse de, tek yıllık gözlem periyodu uzun vadeli eğilimler hakkında kesin sonuçlar çıkarmaya yetmemektedir. Bu araştırma, Derebaşı Kaya Buzulu’nun yüksek çözünürlüklü kinematik değerlendirmesini sağlayarak, jeomorfolojik evrimi ve iklim değişikliğine duyarlılığı konusunda önemli bilgiler sunmaktadır. Gelecekte yapılacak çalışmaların uzun vadeli izleme programları, jeofizik araştırmalar ve sondaj incelemelerini içermesi, döküntü altı buz içeriğinin, permafrost kararlılığının ve kaya buzullarının iklim değişikliğine uzun vadeli tepkisinin daha iyi anlaşılmasına katkı sağlayacaktır.
Эллинистические истоки политической традиции самозванчества и его распространение в России в XVII–XVIII вв.
Authors: Митрофанов А.Ю.
Published: February 2025

Статья посвящена исследованию феномена распространения самозванчества как серьезного политического явления в России в XVII–XVIII вв. (в преддверии эпохи Екатерины Великой). Автор обнаруживает истоки политической традиции самозванчества в политических традициях эллинистического мира (Лже-Филипп, Лже-Александр II), воспринятых римлянами (Лже-Нероны, фальсификация генеалогии Константина Великого) и повлиявших на византийскую политическую систему (Лже-Феодосий, Лже-Тиберий, Лже-Диогены и т. д.). Делаются выводы о динамике византийского самозванчества и о ее влиянии на развитие феномена в Европе Позднего Средневековья (XIV–XV вв.) (Лже-Иоанн Посмертный во Франции, Лже-Эдуард V в Англии), об интенсивности развития самозванчества в России в период Смутного Времени (Лже-Дмитрии, Лже-Петр) и в последующие десятилетия (Лже-Алексеи Алексеевичи, Лже-Алексеи Петровичи, Лже-Петр Петрович и т. д.), о ключевом значении истории конфликта Императора Петра III и Императрицы Екатерины II для эскалации социального конфликта и реанимирования самозванчества в правление Екатерины II (Пугачев, Лже-Иоанны Антоновичи, княжна Тараканова). Статья открывает собой серию публикаций, посвященных проблемам политической истории России XVIII столетия.

The article is devoted to the study of the phenomenon of the spread of imposture as a serious political phenomenon in Russia in the XVII–XVIII centuries. (on the eve of the era of Catherine the Great). The author discovers the origins of the political tradition of imposture in the political traditions of the Hellenistic world (False Philip, False Alexander II), perceived by the Romans (False Nerons, falsification of the genealogy of Constantine the Great) and influenced the Byzantine political system (False Theodosius, False Tiberius, False Diogenes, etc.). Conclusions are drawn about the dynamics of Byzantine imposture and its influence on the development of the phenomenon in Europe of the Late Middle Ages (XIV–XV centuries) (False John the Posthumous in France, False Edward V in England), on the intensity of the development of imposture in Russia during the Time of Troubles (False Dmitry, False Peter) and in subsequent decades (False Aleksey Alekseevich, False Aleksey Petrovich, False Peter Petrovich, etc.), about the key importance of the history of the conflict between Emperor Peter III and Empress Catherine II for the escalation of social conflict and reanimate imposture during the reign of Catherine II (Pugachev, False Ioanna Antonovich, Princess Tarakanova). The article opens a series of publications devoted to the problems of the political history of Russia in the XVIII century.
К вопросу о библиотеке Михаила (Десницкого), митрополита Новгородского и Санкт-Петербургского
Authors: Григорьев А.Б.
Published: February 2025

Проблематика формирования библиотечного фонда духовных семинарий и академий за счет наследования или покупки книжных собраний выдающихся архиереев только недавно начала получать свое освещение в отечественном библиотековедении. Тем интереснее исследовать историю получения библиотечного собрания митрополита Новгородского и Санкт-Петербургского библиотекой Вифанской духовной семинарии с опорой на архивные материалы, хранящиеся в отделе рукописей Российской государственной библиотеки. Рассмотрение этих материалов позволяет нам познакомится с литературными предпочтениями владыки, сформировавшими его богословские воззрения, заново рассмотреть многие исторические оценки его личности, задать новые вопросы о его ближайшем окружении и проследить по архивным документам процесс приобретения и первичного описания и каталогизации экземпляров изданий, а также оценить вероятную возможность идентификации их в современном собрании Российской государственной библиотеки.

The problem of forming the library collections of theological seminaries and academies through the inheritance or purchase of book collections of outstanding bishops has only recently begun to receive coverage in domestic library science. It is all the more interesting to explore the history of the acquisition of the library collection of the Metropolitan of Novgorod and St. Petersburg by the library of the Bethany Theological Seminary, relying on archival materials stored in the OR RSL. Consideration of these materials allows us to get acquainted with the literary preferences of the bishop, which shaped his theological views, re-examine many historical assessments of his personality, ask new questions about his immediate environment and trace the process of acquisition and primary description and cataloging of copies of publications using archival documents, as well as assess the probable the possibility of identifying them in the modern collection of the Russian State Library.
Отчеты обер-прокурора, епархиального преосвященного и начальника губернии как источник по провинциальной церковной истории (на примере отчетной документации по Черниговской губернии и епархии)
Authors: Борисов Н.Ю.
Published: February 2025

При изучении позднесинодального периода в истории Русской Церкви исследователи зачастую используют официальную отчетную документацию второй половины XIX — начала XX вв. К ней можно отнести отчеты обер-прокурора Св. Синода, отчеты о состоянии епархий и отчеты начальников губерний, последние из которых в данной области исследования используются крайне редко. Необходимо отметить, что иногда во всех 3‑х видах документации приводится информация об одних и тех же предметах, при этом подобные сведения разнятся в зависимости от типа источника. В данной статье на примере Черниговской губернии и епархии прослеживается, какие сведения о церковной жизни содержатся в отчетах о состоянии губернии и как они соотносятся с данными, предоставляемыми епархиальным начальством и обер-прокурором Синода. Также с учетом специфики каждой группы источников производится попытка определить, какая группа документов дает наиболее точные и достоверные сведения по провинциальной церковной истории.

When studying the late synodal period in the history of the Russian Church, researchers often use official reporting documentation from the second half of the 19th — early 20th centuries. These include reports of the Chief Prosecutor of the Holy Synod, reports on the state of dioceses and reports of governors, the latter of which are extremely rarely used in this area of research. It should be noted that sometimes all 3 types of documentation provide information on the same subjects, while such information varies depending on the type of source. In this article, using the example of the Chernigov province and diocese, we trace what information about church life is contained in reports on the state of the province and how it correlates with the data provided by the diocesan authorities and the chief prosecutor of the Synod. Also, taking into account the specifics of each group of sources, an attempt is made to determine which group of documents provides the most accurate and reliable information on provincial church history.
Implication of Metal Complexes in Biology and Medicine: The System Aluminum (III)/Chromium (III)/Iron (III) – Homoserine
Authors:   Department of Chemistry, Faculty of Natural Sciences, University of Guyana, Tewari Brij Bhushan
Published: February 2025

Metal ions are fundamental elements for the maintenance of life spans of humans, animals and plants. In coordinatton compounds studies, knowledge of
the stability constants of complexes is necessary for preliminary quantitative treatment. Aluminum prefers oxygen doner groups for complexation. The
stability of complexes in the biological system depends on pH, which is blood plasma is 7.4. Chromium is very adaptable metal and it can form copious
species with variable oxidation numbers from (-VI) to (+VI). Iron is a component of heme and chlorophyll and serves as micronutrients of plants and
animals. Ferric ion from industrial effluent has the potential to poison animals and plants. The present technique involving the use of paper electrophoresis
is described for the study of equilibria in binary complexes system in solution. The method is based on the movement of a spot of a metal ion in an electric
field at various pH’s of background electrolyte. A graph of pH versus mobility was used to obtain information in the binary complexes and to calculate its
stability constants. Using this method, the stability constants of binary complexes, metal (III) – homoserine have been determined to be (8.15 ± 0.03, 6.66
± 0.08); (8.49 ± 0.01, 7.00 ± 0.05); and (8.79 ± 0.01, 7.43 ± 0.03) (logarithm stability constant values) for aluminum (III), chromium (III), and iron (III)
complexes, respectively, at ionic strength 0.1Mol/L and a temperature of 35 °C.
L’émergence et l’évolution de la sémiologie chez Saussure (1881-1894)
Authors: Cosenza Giuseppe
Published: February 2025

This paper is part of a reconstruction of Ferdinand de Saussure’s semiology. The reconstruction is based on a terminological inquiry into different terms related to semiology (Fr. sémiologie). The occurrences of terms were extracted from different Saussurean texts written during the period between 1881 and 1911. The paper also contains two hypotheses about the source of Saussure’s semiology. However, for reasons of space, the detailed analysis of the values of the term “semiologyˮ and related terms is restricted to the period 1881-1894. Our analysis takes up and extends Chidichimo’s essay (2014) on the term “semiologyˮ; the article integrates and clarifies Chidichimo’s analysis of the term “semiologyˮ into a broader and more precise view. Our study shows that the emergence of semiology as a science of signs went through several stages in Ferdinand de Saussure’s thought before being established as a science.
La dualité anthropologique convention sociale / sujet individuel dans la sémiologie saussurienne
Authors: Kharbouch Ahmed
Published: February 2025

Saussure is generally recognized as the one who, together with Peirce, laid the foundations of modern semiotic thought. His influence, like that of the American, is indeed diffuse and crosses different schools and trends in current semiotic research. An essential feature, however, differentiates him from the American philosopher, namely that he puts forward, in his conception of the “science of signs”, a very clear anthropological orientation. This is highlighted, as we will try to show, in the way in which he conceives semiosis as the encounter between the particular “thought” of the individual and the different semiological institutions of society. This necessary encounter within the semiological fact between the subject and the convention constitutes the central duality of the semiotic thought of the Genevan and explains why his semiology is not a formal science.
De l’emploi du génitif absolu en sanscrit (1881) et l’étude de la morphologie sanskrite dans l’œuvre de Saussure
Authors: Bergounioux Gabriel
Published: February 2025

The limits of the subject that Saussure chose for his PhD were a reaction to the requirements of an academic degree. The objections to the Mémoire had convinced him to restrict himself to a philological work whose data he could circumscribe and analyse in a limited time. This article examines the design of the PhD in order to establish its main results, highlighting a number of points of interest such as the artefacts of literacy on grammar, the production of interpretation shared between inflection and context or the attribution of a value (concessive clause), despite the absence of a direct formal mark. The second part examines Saussure’s other contributions on the Sanskrit language as a way to exemplify Indo-European facts or to come to terms with Hélène Smith’s glossolalia.
Correlation analysis between multiple intelligences and learning styles in engineering students
Authors: Terry Borjas Maria Cecilia
Published: February 2025

This paper analyzes the influence of learning styles and multiple intelligence in engineering schools, where thinking is usually more active, and practical, and technical and practical teaching prevails. To this end, a group of 140 students was analyzed to whom the respective questionnaire was applied to learn about the different situations among the participants. It was confirmed that the predominant learning style is pragmatic, however, the dominant intelligence was naturalistic, highlighting that engineering students can focus their efforts on environmental conservation, sustainability, and the environment. In addition, it was confirmed that the recognition of the individual characteristics of students in engineering careers is beneficial to channel future professionals in areas where their contribution to social good and industrial development is more beneficial.
Структурные составляющие производственного потенциала промышленного предприятия
Authors: Афаунова М.Б.
Published: February 2025

В статье исследована структура производственного потенциала предприятия. В основе исследования проблематики формирования производственного потенциала лежит ресурсная база предприятия. Выявлены характерные особенности составляющих элементов производственного потенциала. Указаны оценочные показатели, характеризующие уровень производственного потенциала промышленного предприятия.

The article studies the structure of production potential of the enterprise. The resource base of the enterprise is the basis of the study of the problems of formation of production potential. Characteristic features of the constituent elements of production potential are revealed. The article specifies the evaluation indicators characterizing the level of industrial potential of an industrial enterprise.
Рекомендации по совершенствованию инвестиционного развития сельских поселений (на материалах муниципального образования Абинский район Краснодарского края)
Authors: Дышекова М.Б. , Гусев Д.А.
Published: February 2025

В статье на материалах муниципального образования Аабинский район Краснодарского края даются рекомендации по совершенствованию инвестиционного развития сельских поселений. Отмечается, что инвестиционный процесс крайне динамичен и, следовательно, требует применения гибких форм его организации и управления. Процесс управления инвестиционной деятельностью заключается в выявлении наиболее эффективных (причем рассматривается не только экономическая, но и социальная эффективность) объектов инвестирования, в поиске необходимых для этого ресурсов, разработке соответствующей инвестиционной программы и комплексе мероприятий по ее реализации с целью согласования интересов субъектов системы инвестиционной деятельности муниципального образования.

Based on the materials of the municipal formation of the Abinsky district of the Krasnodar Territory, the article provides recommendations for improving the investment development of rural settlements. It is noted that the investment process is extremely dynamic and, therefore, requires the use of flexible forms of its organization and management. The investment activity management process consists in identifying the most effective (and considering not only economic, but also social efficiency) investment objects, in finding the necessary resources for this, developing an appropriate investment program and a set of measures for its implementation in order to coordinate the interests of the subjects of the investment activity system of the municipality.
Prolonged atrial electromechanical delay and P-wave parameters in asymptomatic carotid artery stenosis: novel insights from a non-invasive evaluation
Authors: Serhatlıoğlu Faruk , Keleşoğlu Şaban
Published: February 2025

Aims: Stroke is one of the top three causes of death in developed societies. Ischemic strokes are linked to carotid artery stenosis (CAS). Atrial fibrillation (AF) is a commonly encountered clinical arrhythmia. It has been shown that the prolongation of intra- and interatrial conduction times, known as atrial electromechanical delay (EMD), is associated with a higher risk of AF. We aimed to determine the correlation of atrial conduction abnormalities between surface electrocardiographic and TDI measurements in the CAS patient group.
Methods: The study included 76 patients diagnosed with extracranial internal carotid artery (ICA) stenosis. Asymptomatic severe CAS was defined as patients with 70-99% stenosis detected by carotid digital subtraction angiography (DSA). The longest P-wave and the longest atrial conduction time ACT were considered as the maximal P-wave duration. The difference between the longest P-wave (Pmax) and the shortest P-wave (Pmin) was accepted as PD. (PD=Pmax-Pmin). Atrial EMD was defined as the time interval from the onset of atrial electrical activity to the beginning of mechanical atrial contraction.
Results: The CAS group had significantly longer Pmax and PD values compared to the control group (Pmax 104.72±6.03 and 93.06±7.26 ms, p
Evaluating the triglyceride glucose index as a novel method for assessing insulin resistance in Turkish women with polycystic ovary syndrome
Authors: Cavnar Helvacı Burçak , Hepşen Sema , Candemir Burcu , Çakal Erman
Published: February 2025

Aims: Polycystic ovary syndrome (PCOS) is a prevalent endocrine disorder in women of reproductive age, characterized by insulin resistance (IR), hyperandrogenism, and polycystic ovary morphology. IR is a significant contributor to the pathogenesis and long-term complications of PCOS, but current gold-standard methods for assessing IR are often impractical for routine clinical use. This study aimed to evaluate the performance of the triglyceride glucose (TyG) index in identifying IR among Turkish women with PCOS and to assess its variability across different PCOS phenotypes.
Methods: This single-center, retrospective study included 247 patients diagnosed with PCOS according to the 2003 Rotterdam criteria. IR was assessed using both the TyG index and HOMA-IR. The study analyzed demographic and clinical data, including fasting plasma glucose, triglycerides, and various metabolic parameters. ROC curve analysis was used to determine the optimal TyG index cutoff for detecting IR.
Results: The mean age of participants was 24.09±5.53 years, with a mean BMI of 28.12±6.38 kg/m². The study identified a mean HOMA-IR of 3.46±1.82 and a mean TyG index of 4.51±0.26. A significant positive correlation was found between HOMA-IR and the TyG index (r=0.370, p
Use and comparison of MTT, XTT and iCELLigence methods in the evaluation of drug toxicity
Authors: Coşkun Demirkalp Ayşe Nur
Published: February 2025

Toxicology tests are one of the fundamental methods used in biological and pharmaceutical research. These tests are used to evaluate the viability, proliferation and toxic responses of cells. The study of biological activities of cells plays a critical role in drug development, cancer research, toxicology and various biotechnological applications. Drug toxicology is an important field of research to determine the harmful effects of drugs on cellular and biological systems. In vitro tests are widely used for accurate evaluation of drugs and their toxic effects. These tests examine the effects of drugs on cell cultures, rapidly revealing their potential harmful effects in terms of time and resources. This review discusses the advantages of the MTT (3-(4,5-dimethylthiazol-2-yl)2,5-diphenyltetrazolium bromide) and XTT (sodium 3'-[1-(phenylamino)-carbonyl]-3,4-tetrazolium]-bis (4 methoxy-6-nitro) benzene-sulfonic acid hydrate) tests, which are widely used as cytotoxicity tests, as well as the newer method iCELLigence. MTT and XTT are widely used and reliable tests that measure cell metabolism; both methods are very effective in assessing cell viability, but provide limited dynamic data. In contrast, iCELLigence is a newer technology and provides more in-depth data by monitoring the real-time responses of cells. iCELLigence continuously monitors the growth rate and morphological changes of cells, allowing for more comprehensive and sensitive results compared to traditional methods. Comparison of these methods allows determining which methodology provides more appropriate results according to different research needs.These tests are also used to define the concentration range over which more comprehensive and detailed in vitro testing can be performed to obtain meaningful data on parameters such as genotoxicity, mutation induction or programmed cell death. This review aims to compare these three methods and discuss their advantages and limitations in the assessment of drug toxicity
Factors affecting pregnancy rates in IVF patients with low ovarian reserve: the role of anti-Müllerian hormone and antral follicle count
Authors: Cok Mehmet , Turan Bakırcı Işıl , Bolluk Gökhan , Aytufan Zübeyde , Köroğlu Nadiye , Özdemir İsmail
Published: February 2025

Aims: This study evaluated in vitro fertilization (IVF) pregnancy rates in patients with low ovarian reserve (LOR), compared pregnancy rates between patients with very low and low anti-Müllerian hormone (AMH) levels, and identified factors affecting pregnancy outcomes.
Methods: We analyzed 311 IVF cycles in 217 women with LOR. Patient selection followed the Bologna criteria for poor ovarian response. We compared the pregnant (n=22) and non-pregnant (n=289) groups for AMH, antral follicle count (AFC), oocyte parameters, and clinical outcomes. Multivariate logistic regression identified the independent predictors of pregnancy success.
Results: Pregnant patients showed higher AFC (4.6±2.4 vs 3.4±2.3, p=0.008) and AMH values (0.6±0.2 vs 0.4±0.3 ng/ml, p=0.024). Patients with AMH ≤0.5 ng/ml had higher cycle cancellation rates (26.1% vs. 4.2%, p