bluuebunny/crossref_metadata_2025 huggingface dataset:
Determinan Smartphone Addiction Dengan Kualitas Tidur Pada Remaja
Authors: Juwariyah Siti , Sovianti Vivi , Septianingtyas Maya Cobalt Angio
Published: August 2023

Teknologi komunikasi yang berkembang saat ini telah memungkinkan manusia terhubung satu sama lain tanpa dibatasi oleh jarak, ruang dan waktu. Pengguna smartphone terbanyak didunia, dan diduduki oleh usia remaja dan dewasa, pengguna smartphone sering kali menghabiskan waktu menggunakan smartphone di malam hari. Kebutuhan tidur dan istirahat remaja bervariasi, pertumbuhan fisik yang cepat, kecenderungan terhadap pengerahan tenaga yang berlebihan, dan keseluruhan aktivitas yang meningkat pada usia ini mengakibatkan terjadinya keletihan pada remaja. Tujuan penelitian ini untuk mengetahui hubungan antara smartphone addiction dengan kualitas tidur pada remaja. Desain dan metode dalam penelitian ini menggunakan penelitian kuantitatif dengan pendekatan korelasional dengan jumlah 75 responden. Menggunakan tehnik simple random sampling. Alat ukur yang digunakan adalah Pittsburgh Sleep Quality Index (PSQI). Hasil penelitian menunjukan bahwa terdapat hubungan yang signifikan antara smartphone addiction dengan kualitas tidur dengan nilai p value 0,043. Remaja memiliki kecanduan smartphone yang tinggi memiliki keterikatan yang kuat terhadap smartphone dan menjadi masalah sosial seperti menarik diri dan kesulitan dalam kegiatan sehari-hari, seperti tidak mengerjakan perkerjaan yang direncanakan, sulit berkonsentrasi, penglihatan kabur, sakit kepala, dan belakang leher merasa sakit atau pegal-pegal serta megalami gangguan tidur. Hal ini akan mengganggu kualitas tidur dari remaja tersebut.
Recent technological innovations in mycelium materials as leather substitutes: a patent review
Authors: Elsacker Elise , Vandelook Simon , Peeters Eveline
Published: August 2023

Leathery mycelium materials, made from the vegetative part of filamentous fungi, have garnered significant interest in recent years due to their great potential of providing environmentally sustainable alternatives to animal- and plastic-based leathers. In this systematic patent review, we provide an in-depth overview of the fabrication methods for mycelium materials as leather substitutes recently described in patents. This overview includes strategies for fungal biomass generation and industrial developments in the sector. We discuss the use of various fungal species, plasticizers, crosslinking agents, and post-processing techniques, thereby highlighting potential gaps in scientific knowledge and identifying opportunities, challenges, and concerns in the field. Our analysis suggests that mycelium materials have significant potential for commercialization, with a growing number of companies betting on this new class of biomaterials. However, we also reveal the need for further scientific research to fully understand the properties of these materials and to unlock potential applications. Overall, this patent review delineates the current state of the art in leathery mycelium materials.
Pullulan-based films impregnated with silver nanoparticles from the Fusarium culmorum strain JTW1 for potential applications in the food industry and medicine
Authors: Wypij Magdalena , Rai Mahendra , Zemljič Lidija Fras , Bračič Matej , Hribernik Silvo , Golińska Patrycja
Published: August 2023

Introduction: Biopolymers, such as pullulan, a natural exopolysaccharide from Aureobasidium pullulans, and their nanocomposites are commonly used in the food, pharmaceutical, and medical industries due to their unique physical and chemical properties.

Methods: Pullulan was synthesized by the A. pullulans ATCC 201253 strain. Nanocomposite films based on biosynthesized pullulan were prepared and loaded with different concentrations of silver nanoparticles (AgNPs) synthesized by the Fusarium culmorum strain JTW1. AgNPs were characterized by transmission electron microscopy, Zeta potential measurements, and Fourier-transform infrared spectroscopy. In turn, the produced films were subjected to physico-chemical analyses such as goniometry, UV shielding capacity, attenuated total reflection–Fourier-transform infrared spectroscopy, scanning electron microscopy, and X-ray photoelectron spectroscopy, and their mechanical and degradation properties were assessed. The antibacterial assays of the nanoparticles and the nanocomposite films against both food-borne and reference pathogens, including Listeria monocytogenes, Salmonella infantis, Salmonella enterica, Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa, and Klebsiella pneumoniae, were performed using standard methods.

Results: AgNPs were small (mean 15.1 nm), spherical, and displayed good stability, being coated with protein biomolecules. When used in higher concentrations as an additive to pullulan films, they resulted in reduced hydrophilicity and light transmission for both UV-B and UV-A lights. Moreover, the produced films exhibited a smooth surface. Therefore, it can be concluded that the addition of biogenic AgNPs did not change the morphology and texture of the films compared to the control film. The nanoparticles and nanocomposite films demonstrated remarkable antibacterial activity against both food-borne and reference bacteria. The highest activity of the prepared films was observed against L. monocytogenes.

Discussion: The obtained results suggest that the novel nanocomposite films prepared from biosynthesized pullulan and AgNPs can be considered for use in the development of medical products and food packaging. Moreover, this is the first report on pullulan-based nanocomposites with mycogenic AgNPs for such applications.
The effect of social network sites on international students' acculturation, adaptation, and wellbeing
Authors: Hofhuis Joep , van Egmond Marieke C. , Lutz Franziska E. , von Reventlow Karin , Rohmann Anette
Published: August 2023

Introduction

A growing body of literature focuses on the impact of social media on well-being of international students. What remains understudied, is how these effects may be explained through acculturation and adaptation processes. This paper examines the mediating roles of acculturation dimensions (cultural maintenance and host country participation) and (psychological and sociocultural) adaptation, on the relationship between host and home Social Network Site (SNS) use and well-being, among two populations.

Methods

Hypotheses were tested using surveys distributed among a diverse group of international students in the Netherlands (n = 147) and a sample of Chinese students in Germany (n = 102).

Results and discussion

The results of both studies show that international students use SNS to initiate contact with the host society, which relates positively to adaptation. However, using SNS to stay in contact with the home culture appears to inhibit the adaptation process, which relates to lower well-being. Our work suggests that these processes are similar across different contexts.
Early long-term low-dosage colchicine and major adverse cardiovascular events in patients with acute myocardial infarction: a systematic review and meta-analysis
Authors: Zhou Yifang , Liu Yidan , Zeng Ruixiang , Qiu Wenjie , Zhao Yunhong , Zhou Yuanshen
Published: August 2023

Background

Current evidence on the efficacy and safety of colchicine after acute myocardial infarction (AMI) remains controversial. This study aims to clarify early low-dose long-term colchicine's exact efficacy and safety in AMI patients via more studies.

Methods

We searched PubMed, Web of Science, Embase, and Cochrane Library databases for randomized controlled trials assessing the efficacy of colchicine on major adverse cardiovascular events (MACE) in recent AMI patients from inception to January 29, 2023, without any restriction. Additionally, we conducted subgroup analyses to assess the impact of early (≤3 days) long-term (≥1 year) low-dosage (0.5 mg/d) colchicine. Summary estimates were computed using Mantel-Haenszel and reported as risk ratios (RRs) or standard mean differences (SMDs), mean differences (MDs) with 95% confidence intervals (CIs). Sensitivity analyses were performed to explore the potential sources of heterogeneity. Review Manager software was used for the meta-analysis.

Results

Eight studies identified from 564 screened records were analyzed, with 5,872 patients after AMI. The length of follow-up varied from five days to 22.7 months, and 0.5–1.0 mg colchicine was administered daily. In summary, compared to the control group, colchicine reduced the occurrence of MACE (RR, 0.56; 95% CI, 0.48–0.67) with 2.99-fold gastrointestinal adverse events in patients with recent AMI. Moreover, the relation referred to a gradual decrease in the occurrence of MACE with a longer follow-up duration (≥1 year) and lower dosage (0.5 mg/d) without leading more gastrointestinal adverse events. Colchicine decreased the follow-up levels of C-reactive protein (CRP) (MD −0.66, 95% CI, −0.98– −0.35) and neutrophils (SMD −0.22, 95% CI, −0.39– −0.55) when the follow-up period was 30 days.

Conclusion

Early long-term low-dose colchicine decreases the risk of MACE via anti-inflammation without leading more gastrointestinal adverse events in patients with AMI.
State-of-the-art methodologies used in preclinical studies to assess left ventricular diastolic and systolic function in mice, pitfalls and troubleshooting
Authors: Pironti Gianluigi
Published: August 2023

Cardiovascular diseases (CVD) are still the leading cause of death worldwide. The improved survival of patients with comorbidities such as type 2 diabetes, hypertension, obesity together with the extension of life expectancy contributes to raise the prevalence of CVD in the increasingly aged society. Therefore, a translational research platform that enables precise evaluation of cardiovascular function in healthy and disease condition and assess the efficacy of novel pharmacological treatments, could implement basic science and contribute to reduce CVD burden. Heart failure is a deadly syndrome characterized by the inability of the heart to meet the oxygen demands of the body (unless there is a compensatory increased of filling pressure) and can manifest either with reduced ejection fraction (HFrEF) or preserved ejection fraction (HFpEF). The development and progression of HFrEF is mostly attributable to impaired contractile performance (systole), while in HFpEF the main problem resides in decreased ability of left ventricle to relax and allow the blood filling (diastole). Murine preclinical models have been broadly used in research to understand pathophysiologic mechanisms of heart failure and test the efficacy of novel therapies. Several methods have been employed to characterise cardiac systolic and diastolic function including Pressure Volume (PV) loop hemodynamic analysis, echocardiography and Magnetic Resonance Imaging (MRI). The choice of one methodology or another depends on many aspects including budget available, skills of the operator and design of the study. The aim of this review is to discuss the importance of several methodologies that are commonly used to characterise the cardiovascular phenotype of preclinical models of heart failure highlighting advantages and limitation of each procedure. Although it requires highly skilled operators for execution, PV loop analysis represents the “gold standard” methodology that enables the assessment of left ventricular performance also independently of vascular loading conditions and heart rate, which conferee a really high physiologic importance to this procedure.
Impacts of clumping effect on canopy reflectance using 3D radiative transfer modeling
Authors: Wu Qiaoli , Yang Shenhui , Jiang Jie
Published: August 2023

The product of leaf area index (LAI) and clumping index (CI) quantifies the effective leaf abundance and distribution across the landscape, and therefore, governs the radiation absorption, evapotranspiration, and carbon assimilation processes in the terrestrial ecosystems. Previous studies were mainly focused on developing inversion methods applicable to large scale for retrieving LAI and CI from multi-angular satellite observations. However, a few studies focused on quantifying the sensitivity of canopy bidirectional reflectance distribution function (BRDF) to changes in CI in a forward manner, hampering an accurate understanding of the relationship between CI and BRDF. In this study, we simulated how BRDF responds to changes in CI in Qinghai spruce (Picea crassifolia) forests based on a 3D radiative transfer model LESS and ground-measured data. We found that the LESS model effectively simulated the hot-spot, roof, and bowl-edge characteristics of the canopy BRDF by changing the sun-sensor geometry. We constructed forest scenes with variable CI (ranging from 0.4 to 0.8) to investigate the clumping effect on BRDF with different solar and observation angles. The red band bidirectional reflectance factor (BRF) showed higher sensitivity to changes in CI than that in the near-infrared (NIR) band. Canopy BRFs in the red band along the principal plane and cross principal planes measured in different seasons showed consistent sensitivity to changes in CI, suggesting that the red band BRF is helpful for CI inversion for forests with different levels of foliage clumping. In the NIR band, canopy BRFs along the principal plane measured in growing seasons [with solar zenith angle (SZA) <40°] and the cross principal plane measured in non-growing seasons (with SZA >40°) were sensitive to changes in CI in highly clumped forests (with CI ranging from 0.4 to 0.6). However, canopy BRF in the NIR band showed low sensitivity to changes in CI in highly clumped forests (CI <0.6), especially along the cross principal plane when SZA was approximately 10°. The simulated BRFs in the red and NIR bands showed relatively low sensitivity to changes in SZAs at a VZA of 40° and 0°, respectively. We highly recommend including the red band BRF for CI retrievals, and using a VZA of 40° in the red band and 0° in the NIR band may help reduce the CI estimation uncertainty caused by changes in SZA. This research provides a new perspective for understanding the sensitivity of multi-angular satellite data to changes in canopy structural characteristics of vegetation in global ecosystem studies and may help improve CI estimations using the multiangular optical remote sensing data.
Experimental study on the bearing property of the composite foundation with stiffened deep cement mixing pile based on the PHC pile
Authors: Feng Tao , Huiqiang Zhu , Fengbo Dong , Shaoqiang Chai , Feng Liu , Ming Zhang
Published: August 2023

Inserting a prestressed high-intensity concrete pipe pile into a cement–soil mixing pile can form a new composite pile named the composite foundation with stiffened deep cement mixing (SDCM) pile. The Huanghuai alluvial stratum in China is selected to carry out the in situ test for the SDCM pile, and the bearing capacity of the SDCM pile is tested by the slow-speed maintenance load method. The results show that for an SDCM pile with dense silt and fine sand as the bearing layer, the characteristic value of bearing capacity can reach 2,300 kN, which means an SDCM pile with a length of 8.0 m meets the load requirement of a general high-rise building. Further analysis shows that the SDCM pile saves more than 40% of the cost compared with the traditional CFG pile and has better quality control advantages at the same time. This research can provide basic data and design references for similar site foundation projects.
Sarcopenia, frailty, and elective surgery outcomes in the elderly: an observational study with 125 patients (the SAFESOE study)
Authors: de Salles Isabel Chateaubriand Diniz , Sernik Renato , da Silva José Luiz Padilha , Taconeli Cesar , Amaral Ana Alice , de Brito Christina May Moran , Bierrenbach Ana Luiza
Published: August 2023

Background

Sarcopenia is a syndrome characterized by loss of muscle mass, strength and function. Frailty, a state of vulnerability with diminished reserves. The measurement of perioperative risk does not include the assessment of these variables, as little is known about how these conditions impact each other.

Methods

Observational study with a cross-sectional and a prospective cohort component. Elderly people over 60 years of age, able to walk and to independently perform activities of daily living were consecutively recruited in the preoperative period of non-emergency surgical procedures. Frailty was measured by the modified frailty index (mFI-11). Sarcopenia was measured by: (1) thickness and echogenicity on ultrasound; (2) handgrip strength on dynamometry and (3) gait speed. Data obtained from eight muscle groups were submitted to Principal Component Analysis. Postoperative complications were measured using the Clavien-Dindo scale. Follow-up was performed for 1 year to record readmissions and deaths.

Results

Between February and May 2019, 125 elderly people were recruited, median age of 71 years (IQR 65–77), 12% of whom were frail. Frailty was associated with older age, use of multiple medicines, presence of multimorbidity and greater surgical risk according to the American Society of Anesthesiologists (ASA) scale, in addition to lower gait speeds and lower handgrip strength. Frailty was also independently associated with smaller measurements of muscle thickness but not with echogenicity, and with longer hospital and Intensive care unit (ICU) stays. Prevalence of sarcopenia was 14% when considering at least two criteria: low walking speed and low handgrip strength. For muscle thickness, lower values were associated with female gender, older age, frailty, lower gait speeds and lower muscle strength, higher proportion of postoperative complications and higher occurrence of death. For echogenicity, higher values were related to the same factors as those of lower muscle thickness, except for postoperative complications. Lower gait speeds and lower handgrip strength were both associated with higher proportions of postoperative complications, and longer hospital stays. A higher mortality rate was observed in those with lower gait speeds.

Conclusion

Sarcopenia was associated with frailty in all its domains. Unfavorable surgical outcomes were also associated with these two conditions.
Non-targeted metabolomics analysis reveals the mechanism of arbuscular mycorrhizal symbiosis regulating the cold-resistance of Elymus nutans
Authors: Zhang Haijuan , Qi Hexing , Lu Guangxin , Zhou Xueli , Wang Junbang , Li Jingjing , Zheng Kaifu , Fan Yuejun , Zhou Huakun , Wang Jiuluan , Wu Chu
Published: August 2023

Elymus nutans is a perennial grass of the Gramineae family. Due to its cold-resistance and nutrition deficiency tolerance, it has been applied to the ecological restoration of degraded alpine grassland on the Qinghai-Tibet Plateau. As an important symbiotic microorganism, arbuscular mycorrhizal fungi (AMF) have been proven to have great potential in promoting the growth and stress resistance of Gramineae grasses. However, the response mechanism of the AMF needs to be clarified. Therefore, in this study, Rhizophagus irregularis was used to explore the mechanism regulating cold resistance of E. nutans. Based on pot experiments and metabolomics, the effects of R. irregularis were investigated on the activities of antioxidant enzyme and metabolites in the roots of E. nutans under cold stress (15/10°C, 16/8 h, day/night). The results showed that lipids and lipid molecules are the highest proportion of metabolites, accounting for 14.26% of the total metabolites. The inoculation with R. irregularis had no significant effects on the activities of antioxidant enzyme in the roots of E. nutans at room temperature. However, it can significantly change the levels of some lipids and other metabolites in the roots. Under cold stress, the antioxidant enzyme activities and the levels of some metabolites in the roots of E. nutans were significantly changed. Meanwhile, most of these metabolites were enriched in the pathways related to plant metabolism. According to the correlation analysis, the activities of antioxidant enzyme were closely related to the levels of some metabolites, such as flavonoids and lipids. In conclusion, AMF may regulate the cold-resistance of Gramineae grasses by affecting plant metabolism, antioxidant enzyme activities and antioxidant-related metabolites like flavonoids and lipids. These results can provide some basis for studying the molecular mechanism of AMF regulating stress resistance of Gramineae grasses.
Case report: A 33 years-old alcoholic male with diarrhea and progressive muscle weakness mimicking Guillain–Barré syndrome
Authors: Rudolph Anja M. , Doubrovinskaia Sofia , Knabbe Johannes , Seliger Corinna , Lenhard Thorsten
Published: August 2023

Background

A subacute manifestation of muscle weakness in temporal association with a diarrheal intestinal infection is always suspicious of Guillain–Barré syndrome (GBS). GBS is characterized as an acute inflammatory polyneuroradiculopathy, mediated by cross-reacting autoantibodies and typically triggered by various infections, vaccinations or other causes. Hyponatremia can be associated with GBS and is usually seen in more severe cases. However, the presence of relevant hyponatremia in a case suspicious of GBS can lead to a diagnostic dilemma. We here describe an intriguing and initially misleading case of hyponatremia mimicking GBS, where repeated and thorough electrophysiology was the key to the correct diagnosis.

Case presentation

A 33 years-old man with a history of severe alcohol dependence and schizophrenia developed progressive muscle weakness in the course of a preceding episode of diarrhea. Neurological examination revealed a leg-accentuated tetraplegia with global areflexia. There was also a complex oculomotor dysfunction. Laboratory tests showed hyponatremia of 110 mM. Cerebrospinal-fluid analysis showed a normal cell count and cytological evaluation, protein concentration within the normal range. Electroneurography showed severe proximal nerve conduction block as evidenced by prolonged F-wave latency and distal nerve conduction block as evidenced by prolonged distal motor latencies and reduced motor nerve conduction velocities (NCV) in all peripheral nerves examined. GBS-associated ganglioside autoantibodies were absent. After compensation of hyponatremia alone, muscle weakness improved rapidly and nerve conduction velocity improved similarly. These dynamics are not consistent with GBS and unnecessary immunoglobulin treatment could be avoided.

Conclusion

Suspicion of GBS in the presence of relevant hyponatremia can be misleading as hyponatremia is able to mimic GBS. We demonstrate that repeated and accurate nerve conduction studies together with F-wave diagnostics is helpful to make the correct diagnosis. We discuss the mechanisms of the causes of hyponatremia in GBS and contrast these with the electropyhsiological changes caused by hyponatremia itself. The correct diagnosis will prevent the uncritical use of intravenous immunoglobulins and save unnecessary costs. Also, a possible aggravation of the hyponatremia by immunoglobulin treatment can be averted.
Mechanical rotational chair-assisted multiple canalith repositioning procedures for benign paroxysmal positional vertigo: enhanced vertigo relief, comparable adverse effects, and decreased incidence of residual dizziness
Authors: Zhang Hao , Zhu Meijia
Published: August 2023

Objectives

This retrospective study aimed to assess the effectiveness and adverse effects of mechanical rotational chair-assisted multiple canalith repositioning procedures (CRPs) to treat benign paroxysmal positional vertigo (BPPV).

Materials and methods

A retrospective analysis of 1,273 BPPV patients was conducted, with 241 patients included in the final study. The participants diagnosed with BPPV, unresolved by a single previous CRP, were categorized into either the single or multiple CRP groups. In both groups, on days 1, 4, and 7 after the initial treatment, the participants were re-evaluated after a single CRP; if positional vertigo was resolved, the treatment was regarded as successful. The remission rate, adverse effects (such as canal switch (CS), falls, and vomiting), residual dizziness (RD) rate, and RD duration were compared between the two groups.

Results

The resolution rates for the single and multiple CRP groups were significantly different on days 1 and 4 (55.7% vs. 85.1%, 75.5% vs. 91.9%; P < 0.05) but not on day 7 (93.3% vs. 94.8%; P > 0.05). There were no significant differences between the single and multiple CRP groups in terms of CS and falls (3.8% vs. 5.2%, 10.3% vs. 8.9%; P > 0.05). However, there was a significant difference in the incidence of vomiting (6.6% vs. 14.8%; P < 0.05). RD such as head heaviness, imbalance, and non-specific dizziness is more common in the single CRP group than in the multiple CRP group (34.9% vs. 20.7%, 42.5% vs. 26.7%, 47.2% vs. 32.6%; P < 0.05). The incidence and duration of RD were notably diminished in the group undergoing multiple CRPs compared to the single CRP group, with incidence rates of 41.5% and 57.5%, respectively (P < 0.05).

Conclusion

For patients with BPPV, multiple CRPs offer greater benefits than a single CRP.
Brain cell type specific proteomics approach to discover pathological mechanisms in the childhood CNS disorder mucolipidosis type IV
Authors: Sangster Madison , Shahriar Sanjid , Niziolek Zachary , Carisi Maria Carla , Lewandowski Michael , Budnik Bogdan , Grishchuk Yulia
Published: August 2023

Mucolipidosis IV (MLIV) is an ultra-rare, recessively inherited lysosomal disorder resulting from inactivating mutations in MCOLN1, the gene encoding the lysosomal cation channel TRPML1. The disease primarily affects the central nervous system (CNS) and manifests in the first year with cognitive and motor developmental delay, followed by a gradual decline in neurological function across the second decade of life, blindness, and premature death in third or fourth decades. Brain pathology manifestations in MLIV are consistent with hypomyelinating leukodystrophy with brain iron accumulation. Presently, there are no approved or investigational therapies for MLIV, and pathogenic mechanisms remain largely unknown. The MLIV mouse model, Mcoln1−/− mice, recapitulates all major manifestations of the human disease. Here, to better understand the pathological mechanisms in the MLIV brain, we performed cell type specific LC–MS/MS proteomics analysis in the MLIV mouse model and reconstituted molecular signatures of the disease in either freshly isolated populations of neurons, astrocytes, oligodendrocytes, and neural stem cells, or whole tissue cortical homogenates from young adult symptomatic Mcoln1−/− mice. Our analysis confirmed on the molecular level major histopathological hallmarks of MLIV universally present in Mcoln1−/− tissue and brain cells, such as hypomyelination, lysosomal dysregulation, and impaired metabolism of lipids and polysaccharides. Importantly, pathway analysis in brain cells revealed mitochondria-related alterations in all Mcoln1−/− brain cells, except oligodendrocytes, that was not possible to resolve in whole tissue. We also report unique proteome signatures and dysregulated pathways for each brain cell population used in this study. These data shed new light on cell-intrinsic mechanisms of MLIV and provide new insights for biomarker discovery and validation to advance translational studies for this disease.
Effect of variety and malting conditions on proteolytic activity, free amino nitrogen, and soluble protein contents of two maize varieties (Atp-Y and Coca-sr): amylolytic activity and physico-chemical and functional properties of optimal sample
Authors: Tene Stephano Tambo , Adebo Oluwafemi Ayodeji , Ndinteh Derek Tantoh , Olusegun Obilana Anthony , Foffe Hermann Arantes Kohole , Kenfack Justine Odelonne , Kamdem Michael Hermann Kengne , Klang Julie Mathilde , Womeni Hilaire Macaire
Published: August 2023

Introduction

The utilization of sprouted meals in beer production and enhancing the physicochemical properties of supplementary foods is widespread in Africa. This work aimed to determine the influence of soaking, germination, maturation and variety conditions on the physicochemical properties, proteolytic activity, free amino nitrogen (FAN) and soluble protein contents of Coca-sr and Atp-Y maize varieties.

Methods

To achieve this, the central composite design (CCD) was used for the optimization of five parameters, namely soaking time (18–42 h), plant salt concentration (0.5–1.2%), soaking temperature (25–41°C), sprouting time (80–195 h) and ripening time (17.50–42 h), and following dependent variables were investigated: proteolytic activity, FAN content and soluble protein. Optimal samples flours obtained were then subsequently subjected to physicochemical and functional analysis.

Results

The analysis of results showed that the linear, interactive and quadratic effects of the factors significantly (p<0.05) affected the proteolytic activity, FAN and soluble protein contents of both varieties. The direction of each factor's variation and its effects were not similar in the two varieties. The optimal malting conditions were 7.31 h soaking with 1.678% vegetable salt at a temperature of 34.65°C followed by sprouting for 245.59 h and maturation for 0.765 h for the Atp-Y variety. For the Coca-sr variety, it requires 1.608 h of soaking with 1.678% vegetable salt at a temperature of 51.93°C followed by 273.94 h and 58.73 h for sprouting and ripening time respectively. The meals of Coca-sr produces using these optimal conditions showed a significantly (p<0.05) higher proteolytic activity, FAN and soluble protein content. The amylolytic activity was more pronounced in the Atp-Y variety, as was the content of essential amino acids. The above optimal conditions reduced the content of anti-nutrients (phytates, saponins, oxalates, condensed and hydrolysable tannins), improved the availability of minerals (Ca and Mg), reduced the pH, mass density, water retention capacity and swelling rate.

Conclusion

As a result, the optimal flours of these two maize varieties could be applied in the formulation of supplementary foods, bakery products and beer by industrialists.
Clouclip combined with a questionnaire on the influence factors of myopia in children
Authors: Zhang Ya , Su Ming , Sun Yanhua , Qi Liqin , Gao Lifang , Wu Xueya , Li Yutong , Liu Yanli , Li Wei , Jin Minxiao
Published: August 2023

Purpose

To evaluate eye use behavior in myopic and non-myopic children objectively using Clouclip M2 device and subjectively using questionnaire and compare the results. The study also aimed to assess the relationships between ocular biometric parameters and refractive status.

Methods

Clouclip M2 was used in monitoring eye use behavior and visual environment in children aged 9–11 years. The participants were monitored for 7 days. On the eighth day, data stored in the device were collected, relevant eye examination were conducted and survey questionnaire was administered. The paired sample t-test was used to compare the eye use behavior obtained objectively and subjectively. The relationships between ocular biometric parameters and refractive status were assessed using the Pearson's Correlation analysis.

Results

Spherical equivalent refraction was significantly correlated with axial length, axial length to corneal radius, anterior chamber depth, lens thickness, and corneal radius (P < 0.05). The average time per day spent on near work, the maximum time for single near work, and the average near working distance were significantly lower, and the average total time spent on outdoor activities was significantly longer as determined by questionnaire method than that found using Clouclip M2. Logistic regression analysis revealed that prolonged near work, shorter working distance, presence of parental myopia, and lesser outdoor activities were significant risk factors for myopia.

Conclusions

The childhood myopia is influenced by eye use behavior, eye use environment, and parental myopia. Results from this study further support that biometric and optical parameters of the eye determine refractive status. Being an objective method, Clouclip M2 provides an independent eye use behavior data which potentially are more reliable than obtained from subjective method. Our study provided a theoretical basis for myopia prevention and control in clinical practice.
The effect of liver disease on hepatic microenvironment and implications for immune therapy
Authors: Brown Zachary J. , Ruff Samantha M. , Pawlik Timothy M.
Published: August 2023

Hepatocellular carcinoma (HCC) is the most common primary liver cancer and the fourth leading cause of cancer-related death worldwide. HCC often occurs in the setting of chronic liver disease or cirrhosis. Recent evidence has highlighted the importance of the immune microenvironment in the development and progression of HCC, as well as its role in the potential response to therapy. Liver disease such as viral hepatitis, alcohol induced liver disease, and non-alcoholic fatty liver disease is a major risk factor for the development of HCC and has been demonstrated to alter the immune microenvironment. Alterations in the immune microenvironment may markedly influence the response to different therapeutic strategies. As such, research has focused on understanding the complex relationship among tumor cells, immune cells, and the surrounding liver parenchyma to treat HCC more effectively. We herein review the immune microenvironment, as well as the relative effect of liver disease on the immune microenvironment. In addition, we review how changes in the immune microenvironment can lead to therapeutic resistance, as well as highlight future strategies aimed at developing the next-generation of therapies for HCC.
Comparison of multilayer and single-layer coronary plaque models on stress/strain calculations based on optical coherence tomography images
Authors: Huang Mengde , Maehara Akiko , Tang Dalin , Zhu Jian , Wang Liang , Lv Rui , Zhu Yanwen , Zhang Xiaoguo , Matsumura Mitsuaki , Chen Lijuan , Ma Genshan , Mintz Gary S.
Published: August 2023

Mechanical stress and strain conditions are closely related to atherosclerotic plaque progression and rupture and have been under intensive investigations in recent years. It is well known that arteries have a three-layer structure: intima, media and adventitia. However, in vivo image-based multilayer plaque models are not available in the current literature due to lack of multilayer image segmentation data. A multilayer segmentation and repairing technique was introduced to segment coronary plaque optical coherence tomography (OCT) image to obtain its three-layer vessel structure. A total of 200 OCT slices from 20 patients (13 male; 7 female) were used to construct multilayer and single-layer 3D thin-slice models to calculate plaque stress and strain and compare model differences. Our results indicated that the average maximum plaque stress values of 20 patients from multilayer and single-layer models were 385.13 ± 110.09 kPa and 270.91 ± 95.86 kPa, respectively. The relative difference was 42.2%, with single-layer stress serving as the base value. The average mean plaque stress values from multilayer and single-layer models were 129.59 ± 32.77 kPa and 93.27 ± 18.20 kPa, respectively, with a relative difference of 38.9%. The maximum and mean plaque strain values obtained from the multilayer models were 11.6% and 19.0% higher than those from the single-layer models. Similarly, the maximum and mean cap strains showed increases of 9.6% and 12.9% over those from the single-layer models. These findings suggest that use of multilayer models could improve plaque stress and strain calculation accuracy and may have large impact on plaque progression and vulnerability investigation and potential clinical applications. Further large-scale studies are needed to validate our findings.
Alexithymia and asthma: a systematic review
Authors: Silvestro Orlando , Ricciardi Luisa , Catalano Antonino , Vicario Carmelo Mario , Tomaiuolo Francesco , Pioggia Giovanni , Squadrito Giovanni , Schwarz Peter , Gangemi Sebastiano , Martino Gabriella
Published: August 2023

Growing evidence from scientific research elucidates the important role of alexithymia in chronic immune diseases. This Review aims to explore the presence of alexithymia in patients affected by asthma and clarify its associations with other involved psychological and physical factors. In January 2023, according to PRISMA guidelines, a systematic search using PubMed and Scopus was conducted. Twenty-six studies were eligible based on inclusion criteria. Alexithymia was significantly present in asthma patients, with most studies reporting a higher prevalence (from 9 to 62.8%) than in control groups (approximately 10%). The coexistence of asthma and alexithymia was associated with a worse quality of life, psychiatric comorbidity, poor symptom control, and difficulty in recognizing exacerbations of the disease. These results suggest that alexithymia can negatively impact the management of asthma. For this reason, we recommend an accuracy assessment in clinical settings and the implementation of psychological interventions to promote the emotional and physical wellbeing of asthmatic patients.
“A living lab within a lab”: approaches and challenges for scaling digital public health in resource-constrained settings
Authors: Mukherjee Arunima S. , Sahay Sundeep , Kumar Rajesh , Banta Rashi , Joshi Neha
Published: August 2023

A living lab is an emerging concept, particularly in Europe, as a vehicle to develop digital innovations through a process of co-produced design and development, which takes place, physically and socially, in real-life use contexts. However, there is limited research relating to guiding our understanding of the process by which such labs are established, and digital innovations are co-created and scaled to other settings requiring similar solutions. Furthermore, beyond Europe, the concept of a living lab has not found widespread application in low- and middle-income countries (LMICs), particularly in their public health contexts. Public health systems offer the unique scaling challenge of “all or nothing”, implying that data are required from the whole population rather than isolated pilot settings. The living lab approach promises the rich potential to strengthen public systems but comes with twin interconnected challenges. First, for building appropriate digital solutions to address local public health challenges, and second, in scaling them to other public health facilities. This article investigates these twin challenges through ongoing empirical work in India and identifies three key domains of analysis, which are as follows: the first concerns the process of establishing an enabling structure of a “living lab within a lab”; the second concerns leveraging the capabilities offered by free and open-source digital technologies; and the third concerns the driving impetus to scaling through agile and co-constructed technical support.
Short-term joint effects of ambient PM2.5 and O3 on mortality in Beijing, China
Authors: Zhang Ying , Zhang Shaobo , Xin Jinyuan , Wang Shigong , He Xiaonan , Zheng Canjun , Li Shihong
Published: August 2023

Introduction

In recent years, air pollution caused by co-occurring PM2.5 and O3, named combined air pollution (CAP), has been observed in Beijing, China, although the health effects of CAP on population mortality are unclear.

Methods

We employed Poisson generalized additive models (GAMs) to evaluate the individual and joint effects of PM2.5 and O3 on mortality (nonaccidental, respiratory, and cardiovascular mortality) in Beijing, China, during the whole period (2014–2016) and the CAP period. Adverse health effects were assessed for percentage increases (%) in the three mortality categories with each 10-μg/m3 increase in PM2.5 and O3. The cumulative risk index (CRI) was adopted as a novel approach to quantify the joint effects.

Results

The results suggested that both PM2.5 and O3 exhibited the greatest individual effects on the three mortality categories with cumulative lag day 01. Increases in the nonaccidental, cardiovascular, and respiratory mortality categories were 0.32%, 0.36%, and 0.43% for PM2.5 (lag day 01) and 0.22%, 0.37%, and 0.25% for O3 (lag day 01), respectively. There were remarkably synergistic interactions between PM2.5 and O3 on the three mortality categories. The study showed that the combined effects of PM2.5 and O3 on nonaccidental, cardiovascular, and respiratory mortality were 0.34%, 0.43%, and 0.46%, respectively, during the whole period and 0.58%, 0.79%, and 0.75%, respectively, during the CAP period. Our findings suggest that combined exposure to PM2.5 and O3, particularly during CAP periods, could further exacerbate their single-pollutant health risks.

Conclusion

These findings provide essential scientific evidence for the possible creation and implementation of environmental protection strategies by policymakers.
The pursuit of intimacy: intimate relationship development for women with physical disabilities
Authors: Ruiz Derek , Kriofske Mainella Alexandra , Rosenthal David A.
Published: August 2023

Background and purpose

Understanding the barriers and facilitators to intimate relationship development among women with physical disabilities is crucial for promoting positive rehabilitation outcomes. This study investigates these factors using a Consensual Qualitative Research approach.

Methods

The research team utilized Consensual Qualitative Research. Consensual Qualitative Research is widely used in various social services to address limitations inherent limitations of other qualitative methods. Women with various physical disabilities (n=6) were identified and interviewed using a utilized a semi-structured interview. Their attitudes towards intimacy, outcome expectancy, and self-concept of women with physical disabilities were examined. The impact of physical disabilities, including disability stigma, on these factors was also assessed. Data was coded utilizing multiple researcher consensus as well as an auditor to consensually agree upon domains and core ideas while taking into account validity and trustworthiness, as per the methodology chosen.

Results

The study discovered general themes (100% representation) concerning core values and barriers to intimacy, societal barriers to intimate relationships, and hope for future relationships. Typical themes (50-83% representation) included non-romantic intimacy, physical barriers to intimacy, perceived limitations, and negative outcome expectancies. Across the board, the influence of disability limitations, identity, and societal attitudes became evident. The role of rehabilitation professionals in advocating for social skills development and self-confidence enhancement emerged as crucial.

Conclusions

The study illuminated barriers to intimacy among women with physical disabilities, such as societal stigma and self-concept associated with disability. The critical role of rehabilitation professionals in normalizing intimacy discussions and equipping individuals with necessary social skills and self-confidence was underscored. This focus could yield enhanced intimate relationship outcomes and improve the quality of life for women with physical disabilities.
Multi-dimensional task recognition for human-robot teaming: literature review
Authors: Baskaran Prakash , Adams Julie A.
Published: August 2023

Human-robot teams collaborating to achieve tasks under various conditions, especially in unstructured, dynamic environments will require robots to adapt autonomously to a human teammate’s state. An important element of such adaptation is the robot’s ability to infer the human teammate’s tasks. Environmentally embedded sensors (e.g., motion capture and cameras) are infeasible in such environments for task recognition, but wearable sensors are a viable task recognition alternative. Human-robot teams will perform a wide variety of composite and atomic tasks, involving multiple activity components (i.e., gross motor, fine-grained motor, tactile, visual, cognitive, speech and auditory) that may occur concurrently. A robot’s ability to recognize the human’s composite, concurrent tasks is a key requirement for realizing successful teaming. Over a hundred task recognition algorithms across multiple activity components are evaluated based on six criteria: sensitivity, suitability, generalizability, composite factor, concurrency and anomaly awareness. The majority of the reviewed task recognition algorithms are not viable for human-robot teams in unstructured, dynamic environments, as they only detect tasks from a subset of activity components, incorporate non-wearable sensors, and rarely detect composite, concurrent tasks across multiple activity components.
Effect of incorporating wing veins on soft wings for flapping micro air vehicles
Authors: Ishiguro Risa , Kawasetsu Takumi , Hosoda Koh
Published: August 2023

Small insects with flapping wings, such as bees and flies, have flexible wings with veins, and their compliant motion enhances flight efficiency and robustness. This study investigated the effects of integrating wing veins into soft wings for micro-flapping aerial vehicles. Prototypes of soft wings, featuring various wing areas and vein patterns in both the wing-chord and wing-span directions, were fabricated and evaluated to determine the force generated through flapping. The results indicated that the force is not solely dependent upon the wing area and is influenced by the wing vein pattern. Wings incorporating wing-chord veins produced more force compared to those with wing-span veins. In contrast, when the wing area was the specific wing area, wings with crossed wing veins, comprising both wing-span veins and wing-chord veins, produced more force. Although wing-chord veins tended to exert more influence on the force generated than the wing-span veins, the findings suggested that a combination of wing-span and wing-chord veins may be requisite, depending upon the wing area.
TCFLTformer: TextCNN-Flat-Lattice Transformer for Entity Recognition of Air Traffic Management Cyber Threat Knowledge Graphs
Authors: Liu Chao , Wang Buhong , Wang Zhen , Tian Jiwei , Luo Peng , Yang Yong
Published: August 2023

With the development of the air traffic management system (ATM), the cyber threat for ATM is becoming more and more serious. The recognition of ATM cyber threat entities is an important task, which can help ATM security experts quickly and accurately recognize threat entities, providing data support for the later construction of knowledge graphs, and ensuring the security and stability of ATM. The entity recognition methods are mainly based on traditional machine learning in a period of time; however, the methods have problems such as low recall and low accuracy. Moreover, in recent years, the rise of deep learning technology has provided new ideas and methods for ATM cyber threat entity recognition. Alternatively, in the convolutional neural network (CNN), the convolution operation can efficiently extract the local features, while it is difficult to capture the global representation information. In Transformer, the attention mechanism can capture feature dependencies over long distances, while it usually ignores the details of local features. To solve these problems, a TextCNN-Flat-Lattice Transformer (TCFLTformer) with CNN-Transformer hybrid architecture is proposed for ATM cyber threat entity recognition, in which a relative positional embedding (RPE) is designed to encode position text content information, and a multibranch prediction head (MBPH) is utilized to enhance deep feature learning. TCFLTformer first uses CNN to carry out convolution and pooling operations on the text to extract local features and then uses a Flat-Lattice Transformer to learn temporal and relative positional characteristics of the text to obtain the final annotation results. Experimental results show that this method has achieved better results in the task of ATM cyber threat entity recognition, and it has high practical value and theoretical contribution. Besides, the proposed method expands the research field of ATM cyber threat entity recognition, and the research results can also provide references for other text classification and sequence annotation tasks.