bluuebunny/crossref_metadata_2025 huggingface dataset:
Conceptualising touch in VR
Authors: Price Sara , Jewitt Carey , Yiannoutsou Nikoleta
Published: January 2021

How touch is conceptualised matters in shaping technical advancements, bringing opportunities and challenges for development and design and raising questions for how touch experience is reconfigured. This paper explores the notion of touch in virtual reality (VR). Specifically, it identifies how touch ‘connection’ is realised and conceptualised in virtual spaces in order to explore how digital remediation of touch in VR shapes the sociality of touch experiences and touch practices. Ten participants from industry and academia with an interest in touch in virtual contexts were interviewed using an in-depth semi-structured approach to elicit experiences and perspectives around the role of touch in VR. Data analysis shows the growing value and significance of touch in virtual spaces and reveals particular ways in which touch is talked about, implemented and conceptualised. It highlights changes for the sociality of touch through participants’ conceptualisations of touch as replication and illusion, and how the body is brought into this ‘touch’ space. These perspectives of touch shape who touches, what is touched and how it is touched and set an agenda for the types of touch that are facilitated by VR. The findings suggest ways in which technological techniques can be employed towards interpretive designs of touch that allow for new ways to look at touch and haptics. They also show how touch is distorted and disrupted in ways that have implications for disturbing established ‘real world’ socialities of touch as well as their renegotiation by users in the space of digitally mediated touch in VR.
Correction to: Herding mechanisms to maintain the cohesion of a harem group: two interaction phases during herding
Authors: Ringhofer Monamie , Go Clark Kendrick , Inoue Sota , S. Mendonça Renata , Hirata Satoshi , Kubo Takatomi , Ikeda Kazushi , Yamamoto Shinya
Published: January 2021

The article Herding mechanisms to maintain the cohesion of a harem group.
Limitations of Nanoparticles Size Characterization by Asymmetric Flow Field‑Fractionation Coupled with Online Dynamic Light Scattering
Authors: Giorgi Francesco , Curran Judith M. , Gilliland Douglas , La Spina Rita , Whelan Maurice , Patterson Eann A.
Published: January 2021

The development of reliable protocols suitable for the characterisation of the physical properties of nanoparticles in suspension is becoming crucial to assess the potential biological as well as toxicological impact of nanoparticles. Amongst sizing techniques, asymmetric flow field flow fractionation (AF4) coupled to online size detectors represents one of the most robust and flexible options to quantify the particle size distribution in suspension. However, size measurement uncertainties have been reported for on-line dynamic light scattering (DLS) detectors when coupled to AF4 systems. In this work we investigated the influence of the initial concentration of nanoparticles in suspension on the sizing capability of the asymmetric flow field-flow fractionation technique coupled with an on-line dynamic light scattering detector and a UV–Visible spectrophotometer (UV) detector. Experiments were performed with suspensions of gold nanoparticles with a nominal diameter of 40 nm and 60 nm at a range of particle concentrations. The results obtained demonstrate that at low concentration of nanoparticles, the AF4-DLS combined technique fails to evaluate the real size of nanoparticles in suspension, detecting an apparent and progressive size increase as a function of the elution time and of the concentration of nanoparticles in suspension.
Rapid mapping of landslides in the Western Ghats (India) triggered by 2018 extreme monsoon rainfall using a deep learning approach
Authors: Meena Sansar Raj , Ghorbanzadeh Omid , van Westen Cees J. , Nachappa Thimmaiah Gudiyangada , Blaschke Thomas , Singh Ramesh P. , Sarkar Raju
Published: January 2021

Rainfall-induced landslide inventories can be compiled using remote sensing and topographical data, gathered using either traditional or semi-automatic supervised methods. In this study, we used the PlanetScope imagery and deep learning convolution neural networks (CNNs) to map the 2018 rainfall-induced landslides in the Kodagu district of Karnataka state in the Western Ghats of India. We used a fourfold cross-validation (CV) to select the training and testing data to remove any random results of the model. Topographic slope data was used as auxiliary information to increase the performance of the model. The resulting landslide inventory map, created using the slope data with the spectral information, reduces the false positives, which helps to distinguish the landslide areas from other similar features such as barren lands and riverbeds. However, while including the slope data did not increase the true positives, the overall accuracy was higher compared to using only spectral information to train the model. The mean accuracies of correctly classified landslide values were 65.5% when using only optical data, which increased to 78% with the use of slope data. The methodology presented in this research can be applied in other landslide-prone regions, and the results can be used to support hazard mitigation in landslide-prone regions.
The root causes of landslide vulnerability in Bangladesh
Authors: Ahmed Bayes
Published: January 2021

Communities living in the Chittagong Hill Districts (CHD) of Bangladesh recurrently observe landslide disasters during the monsoon season (June–September). CHD is primarily dominated by three distinct groups of hill communities, namely, urbanised hill (Bengali), indigenous tribal and stateless Rohingya refugees. Landslide vulnerability amongst them is complex and varies between physical, social, economic, environmental, institutional and cultural dimensions. This study aims to understand driving forces of landslide disasters in the region by emphasising human factors. Data from the three contrasting communities were collected through participatory workshops, in-depth interviews and fieldwork observation. The participants were local people and landslide experts who were purposefully selected from five case study communities in the CHD. They ranked different socio-economic problems, identified causes of landslides and proposed landslide mitigation action plans. Results suggest that the urbanised Bengali and Rohingya refugee communities are highly vulnerable to landslides. The urbanised hill communities largely deal with poverty, social injustice, lack of planning regulations and illegal hill cutting issues, whereas the Rohingya refugees’ predominant constraints are linked to the ongoing genocide and state-sponsored violence in Myanmar hindering their sustainable repatriation, and their protracted living conditions in Bangladesh. The indigenous tribal communities are comparatively resilient to landslides due to their unique history, traditional knowledge, cultural heritage and lifestyle. Landslides in the CHD should be characterised as socio-natural hazards since the components of landslide disasters are profoundly intertwined with the culture–conflict–corruption nexus.
Critical evaluation of the customisation process of the UNDRR disaster resilience scorecard for cities to earthquake-induced soil liquefaction disaster events
Authors: Jones Keith , Pascale Federica , Wanigarathna Nadeeshani , Morga Mariantonietta , Sargin Sinan
Published: January 2021

As cities become larger and more densely populated the impacts of major earthquake events on city communities become more severe. Improving community resilience to earthquake events relies on the complex relationships that exist between different community stakeholder groups (citizens, businesses, community groups, emergency services, critical infrastructure providers, politicians etc.).
This paper reports results from a major EU funded study (LIQUEFACT) that developed a tool for assessing community resilience to Earthquake Induced Liquefaction Disaster (EILD) events. The tool is based on a customised version of the UNDRR Disaster Resilience Scorecard for Cities. The paper reviews alternative approaches to measuring community resilience and describes the process used in the LIQUEFACT project to develop and validate the customised scorecard. The paper presents the results of a questionnaire survey to identify the best generic approach to measure community resilience and a series of semi-structured group interviews to define a range of specific metrics for assessing community resilience to EILD events; and the results of a validation workshop to assess the effectiveness and usability of the customised scorecard. The paper concludes that it is possible to develop a customised version of the UNDRR Scorecard at an appropriate level of granularity to support improved community resilience to earthquake induced soil liquefaction disaster events. The paper also presents key lessons that could assist those developing similar customised versions of the UNDRR scorecard for use in different geographical settings or against different disaster scenarios.
BMO and Elasticity: Korn’s Inequality; Local Uniqueness in Tension
Authors: Spector Daniel E. , Spector Scott J.
Published: January 2021

In this manuscript two BMO estimates are obtained, one for Linear Elasticity and one for Nonlinear Elasticity. It is first shown that the BMO-seminorm of the gradient of a vector-valued mapping is bounded above by a constant times the BMO-seminorm of the symmetric part of its gradient, that is, a Korn inequality in BMO. The uniqueness of equilibrium for a finite deformation whose principal stresses are everywhere nonnegative is then considered. It is shown that when the second variation of the energy, when considered as a function of the strain, is uniformly positive definite at such an equilibrium solution, then there is a BMO-neighborhood in strain space where there are no other equilibrium solutions.
No one can see me cry: understanding mental health issues for Black and minority ethnic staff in higher education
Authors: Arday Jason
Published: January 2021

Black and minority ethnic (BME) communities continue to experience differential outcomes within the United Kingdom (UK) mental health system, despite increased attention on the area. The trauma of racism for BME academic and professional staff within higher education remains problematic against a backdrop of cultural and organisational institutional racism. Within higher education (HE), BME staff consistently face barriers in terms of accessing contextually appropriate mental health interventions that recognise the sophisticated nature of insidious racism in all its overt and covert manifestations. This paper attempts to address the issues facing ethnic minority staff within the Academy with regard to accessing mental health services at university. Importantly, this paper explores the impact of racial discrimination on BME faculty within the sector and the impact upon mental health, in addition to considering the paucity of psychological interventions available in dealing with discriminatory episodes and the need for universities to diversify healthcare professional cohorts. This study utilises the narratives of 40 BME academic and professional university staff to examine the impact of negotiating racial inequality and discrimination at university and the impact upon mental health. Other aspects examined consider the impact of belonging, isolation and marginalisation on mental health and how this consequently affects BME university staff. Conclusions and recommendations provided advocate greater diversification of mental health support systems for BME staff within universities. Conclusions drawn will also consider how existing systems can function to dismantle racial inequality and improve mental health invention for ethnic minority service users.
Psychological Predictors of Homophobic Bullying Among Adolescents and Young Adults: The Role of Parental Psychological Control and Sensation Seeking
Authors: Pace Ugo , D’Urso Giulio , Zappulla Carla
Published: January 2021

We aimed to investigate the relationship between homophobic bullying, parental psychological control and sensation seeking among adolescents and young adults and to examine the mediating role of sensation seeking. The participants included 394 adolescents and young adults aged 15 to 20 years attending the 3rd, 4th and 5th years of two public high schools in Italian cities. Participants completed the Homophobic Bullying Scale, the Dependency—oriented and Achievement—oriented Parental Psychological Control, and the Sensation—Seeking Scale. The results showed that parental psychological control predicted bullying toward gay and lesbian people. However, the two dimensions of sensation seeking (thrill and adventure seeking, and disinhibition) represented two mediators in the relationship between parental psychological control, both achievement and dependency—oriented, and homophobic bullying.
Microwave assisted the short time clean synthesis of 1,3-diketones as building blocks in heterocyclic synthesis: a facile synthesis and antimicrobial evaluation of new dihydropyridine, 4H-pyrane, dihydropyridazine, pyrimidine and pyrazole derivatives
Authors: Abdel Reheim Mohamed Ahmed Mahmoud , Abdel Hafiz Ibrahim Saad , Abdel Rady Hend Saad Eldin
Published: January 2021

The compounds bearing naphthalene moiety can be used as medical preparations because of their wide spectrum of biological activity and low toxicity. In this study, a new series of azoles or azines were synthesized from the reaction of the key intermediate 1-(1-hydroxynaphthalen-2-yl)-3-phenylpropane-1,3-dione 3 with a variety of electrophilic and nucleophilic reagents under a variety of mild conditions. The chemical structures of these compounds were confirmed by various spectroscopic methods such as (IR, 1H-NMR, 13C-NMR, mass spectra and elemental analyses). The prepared compounds were screened in vitro for their anti-microbial activity against some species of Gram-positive bacteria (Staphylococcus aureus and Bacillus subtilis) and Gram-negative bacteria (Escherichia coli and Pseudomonas aeuroginosa). Anti-fungal activities of the compounds were tested against yeast and mycelial fungi,Candida albicans and Aspergillus flavus. The antimicrobial activity of this series was showed either weak or moderate activities.

Graphic abstract
Barycentric prolate interpolation and pseudospectral differentiation
Authors: Tian Yan
Published: January 2021

In this paper, we provide further illustrations of prolate interpolation and pseudospectral differentiation based on the barycentric perspectives. The convergence rates of the barycentric prolate interpolation and pseudospectral differentiation are derived. Furthermore, we propose the new preconditioner, which leads to the well-conditioned prolate collocation scheme. Numerical examples are included to show the high accuracy of the new method. We apply this approach to solve the second-order boundary value problem and Helmholtz problem.
Effect of date palm (Phoenix dactylifera L.) leaves on productive performance of growing lambs
Authors: Mahrous A. A. , El-Tahan A. A. H. , Hafez Y. H. , El-Shora M. A. , Olafadehan O. A. , Hamdon H.
Published: January 2021

Eighteen 4-month-old lambs, with a mean live weight (LW) of 19.47 ± 0.20 kg, were used to evaluate the nutritive value of date palm leaves (DPL) ensiled with different additives in a completely randomized design. Lambs were stratified into three groups of 6 lambs each and fed a control diet comprising 60% concentrate feed mixture (CFM) and 40% DPL silage (T1). In other treatments, the DPL silage (DPLS) of the control treatment was replaced with EM1 additive-treated DPLS (T2) or El-Mofeed additive-treated DPLS (T3). Apparent digestibility, total digestible nutrient, digestible crude protein, dry matter intake, daily weight gain (DWG), price of DWG, daily profit, and economics of feed efficiency were higher (P < 0.05) for the additives-treated DPLS relative to the control, with T2 enhancing these parameters compared with T3. With exception of ruminal pH, which was reduced, concentrations of ruminal NH3-N and total volatile fatty acids (VFA) increased 4 h post feeding. However, ruminal NH3-N and total VFA were greater (P < 0.05) for the additives-treated DPLS, with T2 producing higher values than T3. Ruminal pH and feed cost/kg LW gain were lower for T2 relative to other treatments. Blood constituents were within the normal ranges for lambs, though slightly altered by treatments. Whereas serum total protein, albumin, and globulin were affected (P < 0.05) in this rank order, T1 < T3 < T2, other serum parameters were not affected. Relative feed cost and relative daily profit were lower and higher respectively for T2 than for T3. It is concluded that additives-treated DPLS is nutritionally superior to untreated DPLS as a roughage source in total mixed rations fed to growing lambs. However, for improved performance of the lambs and economic benefits, EM1-treated DPLS is recommended.
Glycerophospholipid and detoxification pathways associated with small for gestation age pathophysiology: discovery metabolomics analysis in the SCOPE cohort
Authors: Morillon Aude-Claire , Leite Debora F. B. , Yakkundi Shirish , Gethings Lee A , Thomas Gregoire , Baker Philip N. , Kenny Louise C. , English Jane A. , McCarthy Fergus P.
Published: January 2021

Introduction

Small for gestational age (SGA) may be associated with neonatal morbidity and mortality. Our understanding of the molecular pathways implicated is poor.

Objectives

Our aim was to determine the metabolic pathways involved in the pathophysiology of SGA and examine their variation between maternal biofluid samples.

Methods

Plasma (Cork) and urine (Cork, Auckland) samples were collected at 20 weeks’ gestation from nulliparous low-risk pregnant women participating in the SCOPE study. Women who delivered an SGA infant (birthweight < 10th percentile) were matched to controls (uncomplicated pregnancies). Metabolomics (urine) and lipidomics (plasma) analyses were performed using ultra performance liquid chromatography-mass spectrometry. Features were ranked based on FDR adjusted p-values from empirical Bayes analysis, and significant features putatively identified.

Results

Lipidomics plasma analysis revealed that 22 out of the 33 significantly altered lipids annotated were glycerophospholipids; all were detected in higher levels in SGA. Metabolomic analysis identified reduced expression of metabolites associated with detoxification (D-Glucuronic acid, Estriol-16-glucuronide), nutrient absorption and transport (Sulfolithocholic acid) pathways.

Conclusions

This study suggests higher levels of glycerophospholipids, and lower levels of specific urine metabolites are implicated in the pathophysiology of SGA. Further research is needed to confirm these findings in independent samples.
Chlorine cycling and the fate of Cl in terrestrial environments
Authors: Svensson Teresia , Kylin Henrik , Montelius Malin , Sandén Per , Bastviken David
Published: January 2021

Chlorine (Cl) in the terrestrial environment is of interest from multiple perspectives, including the use of chloride as a tracer for water flow and contaminant transport, organochlorine pollutants, Cl cycling, radioactive waste (radioecology; 36Cl is of large concern) and plant science (Cl as essential element for living plants). During the past decades, there has been a rapid development towards improved understanding of the terrestrial Cl cycle. There is a ubiquitous and extensive natural chlorination of organic matter in terrestrial ecosystems where naturally formed chlorinated organic compounds (Clorg) in soil frequently exceed the abundance of chloride. Chloride dominates import and export from terrestrial ecosystems while soil Clorg and biomass Cl can dominate the standing stock Cl. This has important implications for Cl transport, as chloride will enter the Cl pools resulting in prolonged residence times. Clearly, these pools must be considered separately in future monitoring programs addressing Cl cycling. Moreover, there are indications that (1) large amounts of Cl can accumulate in biomass, in some cases representing the main Cl pool; (2) emissions of volatile organic chlorines could be a significant export pathway of Cl and (3) that there is a production of Clorg in tissues of, e.g. plants and animals and that Cl can accumulate as, e.g. chlorinated fatty acids in organisms. Yet, data focusing on ecosystem perspectives and combined spatiotemporal variability regarding various Cl pools are still scarce, and the processes and ecological roles of the extensive biological Cl cycling are still poorly understood.
Challenges to open innovation in traditional SMEs: an analysis of pre-competitive projects in university-industry-government collaboration
Authors: Bertello Alberto , Ferraris Alberto , De Bernardi Paola , Bertoldi Bernardo
Published: January 2021

Governments are increasingly focusing their efforts on stimulating innovation within small and medium-sized enterprises (SMEs). As a result, university-industry-government collaboration is gaining importance among the agenda of policymakers to enable open innovation in SMEs. However, these inter-organisational relationships often fail to meet expectations, especially when projects are oriented to pre-competitive R&D. Nevertheless, the literature has not yet provided sufficient evidence of the challenges related to the participation of traditional SMEs (i.e., low- and medium-low tech SMEs) in this specific type of collaboration. We collected qualitative data to analyse longitudinally three pre-competitive projects, exploring the main challenges faced by traditional SMEs. We have bracketed the projects in four phases: initiation and planning phase, execution phase, closing phase, and monitoring and control phase. For each of these phases we have individuated firm- and project-level challenges, providing practical and theoretical insights for open innovation scholars.
Colorectal Cancer Screening and Surveillance for Non-Hereditary High-Risk Groups—Is It Time for a Re-Think?
Authors: Hampton James S. , Sharp Linda , Craig Dawn , Rees Colin J.
Published: January 2021

Purpose of review

Colorectal cancer (CRC) is the second most common cause of cancer death worldwide, killing approximately 900,000 people each year. An individual’s risk of developing CRC is multi-factorial with known risk factors including increasing age, male sex, family history of CRC and raised body mass index. Population-based screening programmes for CRC exist in many countries, and in the United Kingdom (UK), screening is performed through the NHS Bowel Cancer Screening Programme (BCSP). Screening programmes offer a population-based approach for those at “average risk”, and do not typically offer enhanced screening for groups at increased risk. In the UK, such patients are managed via non-screening symptomatic services but in a non-systematic way.

Recent findings

There is growing evidence that conditions such as cystic fibrosis and a history of childhood cancer are associated with higher risk of CRC, and surveillance of these groups is advocated by some organizations; however, national recommendations do not exist in most countries.

We review the evidence for screening “high risk” groups not covered within most guidelines and discuss health economic issues requiring consideration acknowledging that the demand on colonoscopy services is already overwhelming.
Heuristic and systematic processing differentially influence the effects of scientific consensus messaging on perceived scientific consensus
Authors: Kobayashi Keiichi
Published: January 2021

This study investigated the impact of scientific consensus messaging on perceived scientific consensus in terms of heuristic and systematic processing. Japanese undergraduates (N = 226) received a message indicating relatively moderate and high levels of scientific consensus on the safety of foods grown with pesticides and genetically modified (GM) foods. Participants in the presentation-style evaluation condition evaluated the style and manner of providing the message and thereby were encouraged to heuristically process information about scientific consensus in the message. Participants in the content evaluation condition evaluated the message content and therefore could process the information systematically. After evaluating the message, participants’ perceptions of scientific consensus improved. The levels of posteriorly perceived scientific consensus were higher for the presentation-style evaluation condition than for the content evaluation condition. Participants’ initial beliefs about the GM-food safety predicted their posterior perceptions of scientific consensus for the content evaluation condition but not for the presentation-style evaluation condition. These results suggest that the heuristic and systematic processing of scientific consensus information differentially influence the impact of scientific consensus messaging.
Selective Transport of Airborne Microparticles Through Micro-channels Under Microgravity
Authors: Makhoul Monia , Beltrame Philippe
Published: January 2021

This paper analyzes the possibility of obtaining the selective transport of microparticles suspended in air in a microgravity environment through modulated channels without net displacement of air. Using numerical simulation and bifurcation analysis tools, we show the existence of intermittent particle drift under the Stokes assumption of the fluid flow. The particle transport can be selective and the direction of transport is controlled only by the kind of pumping used. The selective transport is interpreted as a deterministic ratchet effect due to spatial variations in the flow and the particle drag. This ratchet phenomenon could be applied to the selective transport of metal particles during the short duration of microgravity experiments.
The first case of balloon-occluded retrograde transvenous obliteration and partial splenic embolization for gastric varices in situs inversus abdominus
Authors: Watanabe Yusuke , Osaki Akihiko , Waguri Nobuo , Terai Shuji
Published: January 2021

Situs inversus abdominus is a congenital abnormality characterized by the mirror image positioning of the abdominal organs, making it difficult to diagnosis and treatment of many diseases. Here, we report a rare case of gastric varices in situs inversus abdominus patient. A 55-year-old man was diagnosed with F2-shaped gastric varices associated with alcoholic cirrhosis. Abdominal dynamic computed tomography showed situs inversus abdominus, and gastric varices with a gastrorenal shunt. Due to the complex anatomy, emergency interventional radiology during bleeding was extremely difficult. Therefore, after thorough consultation, we decided to treat gastric varices prophylactically by balloon-occluded retrograde transvenous obliteration. After treatment, the patient’s clinical course was generally good, with no adverse events, and the gastric varices disappeared. It is important to assess anatomical positioning using three-dimensional reconstruction computed tomography images before treatment, to adequately prepare, including selecting appropriate devices (i.e., catheters and sheath). Although preventive treatment of gastric varices is controversial, in cases with anatomical complexity, preventive treatment with sufficient preparation would be recommended. To the best of our knowledge, there are no reports of treatment for gastric varices in situs inversus abdominus patient. This case will serve as a reference for successful treatment in future cases.
Decentralised energy and its performance assessment models
Authors: Wu Ting , Xu Dong-Ling , Yang Jian-Bo
Published: January 2021

Energy development concerns not only the development of renewable energies but also the shift from centralised to clean, decentralised power generation. The development of decentralised energy (DE) is a core part of the energy and economic strategies being adopted around the world that drives the progress toward a highly sustainable future. This paper reviews the concepts, development status, trends, benefits and challenges of DE systems and analyses the existing models and methods for assessing the performance of these systems. A hierarchical decision model for evaluating the performance of DE systems is also constructed based on the framework of multiple criteria decision analysis, which considers the identification, definition and assessment grade of decision criteria. The evidential reasoning approach is applied to aggregate assessment information in a case study of the implementation of an intelligent decision system. Sensitivity and trade-off analyses are also conducted to show how the proposed model can be used to support decision making in DE systems.
Laterite as a Potential Seepage Barrier From a Karst-Depression Tailings Impoundment
Authors: Gao Hai-Yan , Xu Ze-Min , Ren Zhe , Wang Kun , Yang Kui , Tang Yong-Jun , Luo Jun-Yao
Published: January 2021

In the absence of the necessary valley topography, karst depressions are sometimes used to construct conventional impoundments in order to contain tailings. Leakage is a primary concern for such impoundments. The purpose of the current study was to determine the characteristics and barrier performance of laterite mantling karst depressions, using, as an example, the Wujiwatang (WJWT) tailings impoundment, located in the Gejiu mining area, southwestern China. The geotechnical-hydrogeological properties, geochemistry, mineral compositions, and particle shapes of the laterite were investigated by geotechnical techniques, chemical analysis, X-ray diffraction (XRD), and scanning electron microscopy (SEM). The results showed that the laterite contained poorly sorted particles that covered a wide spectrum of grain sizes (<5 mm to <50 nm), and was unexpectedly categorized as silty clay or silt with a high liquid limit. The continuous gradation and small D90 value helped the laterite achieve saturated hydraulic conductivities in the range of <10–6 cm/s required for impoundment liners. The laterite beneath the tailings impoundment was finer-grained and had a lower permeability than that of the laterite on the depression walls within the same depression. Geochemically and mineralogically, the laterite was classified as true laterite and its major mineralogical constituents were gibbsite and goethite with chlorite occurring in trace amounts. The laterite was dominated by subspherolitic–spherolitic cohesionless grains (concretions) made up of Al, Fe, Ti, and Mn oxides and hydroxides. The laterite did not have plasticity indices in the clay range. Fortunately, slopewash prior to tailings containment selectively transported the finer oxide concretions to the depression floor, creating a natural low-permeability barrier for the WJWT tailings impoundment. This is undoubtedly important for the planning and design of future karst depression-type tailings impoundments around the world.
Motivation for Drinking Wine
Authors: Gustavsen Geir W. , Rickertsen Kyrre
Published: January 2021

We used a survey to investigate some motives for drinking red, sparkling, and white wine among 3,433 Norwegian respondents. Respondents with interest in wine drank all types of wine more frequently than those with little interest. Interest in cultural activities, which often are associated with wine consumption, also increased the frequency of consumption of all types of wine. Respondents who scored high on conspicuous attitudes drank sparkling and white wine more frequently than respondents with low scores. However, conspicuous attitudes did not affect the frequency of red wine consumption. (JEL Classifications: D12, Q13).
The Impact of the European Grapevine Moth on Grape Production: Implications for Eradication Programs
Authors: Puga German , Umberger Wendy , Gennari Alejandro
Published: January 2021

The European grapevine moth is one of the most pertinent viticulture pests. In recent years, the moth extended to New World countries, some of which started eradication programs. We used a dataset for Mendoza and a county-fixed effects regression model to estimate the impact of the moth on grape production across the province's counties. Our results suggest that the moth led to a decrease of up to 8% of Mendoza's grape production; however, this may have been worse without strong eradication efforts. We conclude that moth eradication programs may be economically justified in Argentina, and perhaps in other countries. (JEL Classifications: Q10, Q18, C23)
Competitive Authoritarianism in Morales’s Bolivia: Skewing Arenas of Competition
Authors: Sánchez-Sibony Omar
Published: January 2021

The attempt to classify Bolivia under Evo Morales has yielded a bewildering range of regime labels. While most scholars label it a democracy with adjectives, systematic appraisals of the regime have been scant. This article aims fill this gap by providing a more systematic evaluation, putting special emphasis on features of Bolivia’s electoral playing field. It evaluates the slope of key fields of competition (electoral, legislative, judicial, and mass media), finding abundant evidence that all four were substantively slanted in favor of the incumbent. During the MAS reign, political competition was genuine but fundamentally unfree and unfair, because the ruling party benefited from a truncated supply of electoral candidates; much greater access to finance; a partisan electoral management body; supermajorities in the legislature, used to dispense authoritarian legalism; a captured and weaponized judiciary; and a co-opted mass media ecosystem. Contrary to most extant characterizations, the regime is best categorized as competitive authoritarian.
The influence of pre-existing hypertension on coronavirus disease 2019 patients
Authors: Wei Zhi-Yao , Qiao Rui , Chen Jian , Huang Ji , Wu Hui , Wang Wen-Jun , Yu Hua , Xu Jing , Wang Chao , Gu Chong-Huai , Li Hong-Jiang , Li Mi , Liu Cong , Yang Jun , Wang Yang , Wang Hao-Yu , Qian Hai-Yan , Geng Yong-Jian
Published: January 2021

Hypertension represents one of the most common pre-existing conditions and comorbidities in Coronavirus disease 2019 (COVID-19) patients. To explore whether hypertension serves as a risk factor for disease severity, a multi-centre, retrospective study was conducted in COVID-19 patients. A total of 498 consecutively hospitalised patients with lab-confirmed COVID-19 in China were enrolled in this cohort. Using logistic regression, we assessed the association between hypertension and the likelihood of severe illness with adjustment for confounders. We observed that more than 16% of the enrolled patients exhibited pre-existing hypertension on admission. More severe COVID-19 cases occurred in individuals with hypertension than those without hypertension (21% vs. 10%, P = 0.007). Hypertension associated with the increased risk of severe illness, which was not modified by other demographic factors, such as age, sex, hospital geological location and blood pressure levels on admission. More attention and treatment should be offered to patients with underlying hypertension, who usually are older, have more comorbidities and more susceptible to cardiac complications.
An analysis of coronavirus disease 2019 with spline regression at province level during first-level response to major public health emergency out of Hubei, China
Authors: Liang Chen , Shen Li
Published: January 2021

This study aims to locate the knots of cumulative coronavirus disease 2019 (COVID-19) case number during the first-level response to public health emergency in the provinces of China except Hubei. The provinces were grouped into three regions, namely eastern, central and western provinces, and the trends between adjacent knots were compared among the three regions. COVID-19 case number, migration scale index, Baidu index, demographic, economic and public health resource data were collected from 22 Chinese provinces from 19 January 2020 to 12 March 2020. Spline regression was applied to the data of all included, eastern, central and western provinces. The research period was divided into three stages by two knots. The first stage (from 19 January to around 25 January) was similar among three regions. However, in the second stage, growth of COVID-19 case number was flatter and lasted longer in western provinces (from 25 January to 18 February) than in eastern and central provinces (from 26 February to around 11 February). In the third stage, the growth of COVID-19 case number slowed down in all the three regions. Included covariates were different among the three regions. Overall, spline regression with covariates showed the different change patterns in eastern, central and western provinces, which provided a better insight into regional characteristics of COVID-19 pandemic.
Impact of Lockdown due to COVID-19 on the Modalities of Intoxicated Patients Presenting to the Emergency Room
Authors: Fayed Manar M. , Sharif Asmaa F.
Published: January 2021

Introduction:

Coronavirus disease 2019 (COVID-19) pandemic influences health care facilities world-wide. The flow rate, type, and severity of cases presented to emergency departments varied during the pandemic in comparison to the past years. However, this change has not been well-described among the cases of hospital admission due to toxic exposure.

Study Objective:

Recognition of the pattern of toxic exposure among the cases refereed to Tanta Poison Control Center (TPCC; Tanta, Egypt) during the past five years, and furthermore, exploration of the impact of lockdown due to the COVID-19 pandemic on the pattern of presented cases.

Methods:

The current study is a five-year retrospective, comparative cross-sectional study carried out among acutely intoxicated patients admitted to TPCC during the spring months (March through May) of 2016-2020. A total of 1,916 patients with complete medical records were recruited. The type and manner of toxic exposure, demographic, clinical data, and outcomes were analyzed.

Results:

The current study noted that there were delays in time from toxic exposure to emergency services during the lockdown period. This was reflected in significant lower recovery rates (884.8/1,000 population; z = −3.0) and higher death rates (49.4/1,000 population; z = 2.1) despite the marked decrease in the total number of hospital admissions in comparison to the past four years. The lockdown period showed significantly higher phosphides (z = 3.5; χ2= 34.295; P <.001) and antipsychotics exposure (z = 3.6; χ2= 21.494; P <.001) than the previous years. However, predominance of female exposure and intentional self-poisoning was maintained over the past five years, including the lockdown.

Conclusion:

COVID-19-associated lockdown greatly reformed the usual intoxication pattern of the cases admitted to emergency room. Also, it played a role in delaying time of hospital arrival, which was reflected as lower recovery rates and higher death rates.
High-sensitivity nanophotonic sensors with passive trapping of analyte molecules in hot spots
Authors: Miao Xianglong , Yan Lingyue , Wu Yun , Liu Peter Q.
Published: January 2021

Nanophotonic resonators can confine light to deep-subwavelength volumes with highly enhanced near-field intensity and therefore are widely used for surface-enhanced infrared absorption spectroscopy in various molecular sensing applications. The enhanced signal is mainly contributed by molecules in photonic hot spots, which are regions of a nanophotonic structure with high-field intensity. Therefore, delivery of the majority of, if not all, analyte molecules to hot spots is crucial for fully utilizing the sensing capability of an optical sensor. However, for most optical sensors, simple and straightforward methods of introducing an aqueous analyte to the device, such as applying droplets or spin-coating, cannot achieve targeted delivery of analyte molecules to hot spots. Instead, analyte molecules are usually distributed across the entire device surface, so the majority of the molecules do not experience enhanced field intensity. Here, we present a nanophotonic sensor design with passive molecule trapping functionality. When an analyte solution droplet is introduced to the sensor surface and gradually evaporates, the device structure can effectively trap most precipitated analyte molecules in its hot spots, significantly enhancing the sensor spectral response and sensitivity performance. Specifically, our sensors produce a reflection change of a few percentage points in response to trace amounts of the amino-acid proline or glucose precipitate with a picogram-level mass, which is significantly less than the mass of a molecular monolayer covering the same measurement area. The demonstrated strategy for designing optical sensor structures may also be applied to sensing nano-particles such as exosomes, viruses, and quantum dots.
Toward optical coherence tomography on a chip: in vivo three-dimensional human retinal imaging using photonic integrated circuit-based arrayed waveguide gratings
Authors: Rank Elisabet A. , Sentosa Ryan , Harper Danielle J. , Salas Matthias , Gaugutz Anna , Seyringer Dana , Nevlacsil Stefan , Maese-Novo Alejandro , Eggeling Moritz , Muellner Paul , Hainberger Rainer , Sagmeister Martin , Kraft Jochen , Leitgeb Rainer A. , Drexler Wolfgang
Published: January 2021

In this work, we present a significant step toward in vivo ophthalmic optical coherence tomography and angiography on a photonic integrated chip. The diffraction gratings used in spectral-domain optical coherence tomography can be replaced by photonic integrated circuits comprising an arrayed waveguide grating. Two arrayed waveguide grating designs with 256 channels were tested, which enabled the first chip-based optical coherence tomography and angiography in vivo three-dimensional human retinal measurements. Design 1 supports a bandwidth of 22 nm, with which a sensitivity of up to 91 dB (830 µW) and an axial resolution of 10.7 µm was measured. Design 2 supports a bandwidth of 48 nm, with which a sensitivity of 90 dB (480 µW) and an axial resolution of 6.5 µm was measured. The silicon nitride-based integrated optical waveguides were fabricated with a fully CMOS-compatible process, which allows their monolithic co-integration on top of an optoelectronic silicon chip. As a benchmark for chip-based optical coherence tomography, tomograms generated by a commercially available clinical spectral-domain optical coherence tomography system were compared to those acquired with on-chip gratings. The similarities in the tomograms demonstrate the significant clinical potential for further integration of optical coherence tomography on a chip system.
G9a controls pluripotent-like identity and tumor-initiating function in human colorectal cancer
Authors: Bergin Christopher J. , Zouggar Aïcha , Haebe Joshua R. , Masibag Angelique N. , Desrochers François M. , Reilley Simon Y. , Agrawal Gautam , Benoit Yannick D.
Published: January 2021

Colorectal tumors are hierarchically organized and governed by populations of self-renewing cancer stem cells, representing one of the deadliest types of cancers worldwide. Emergence of cancer stemness phenotype depends on epigenetic reprogramming, associated with profound transcriptional changes. As described for pluripotent reprogramming, epigenetic modifiers play a key role in cancer stem cells by establishing embryonic stem-like transcriptional programs, thus impacting the balance between self-renewal and differentiation. We identified overexpression of histone methyltransferase G9a as a risk factor for colorectal cancer, associated with shorter relapse-free survival. Moreover, using human transformed pluripotent cells as a surrogate model for cancer stem cells, we observed that G9a activity is essential for the maintenance of embryonic-like transcriptional signature promoting self-renewal, tumorigenicity, and undifferentiated state. Such a role was also applicable to colorectal cancer, where inhibitors of G9a histone methyltransferase function induced intestinal differentiation while restricting tumor-initiating activity in patient-derived colorectal tumor samples. Finally, by integrating transcriptome profiling with G9a/H3K9me2 loci co-occupancy, we identified the canonical Wnt pathway, epithelial-to-mesenchyme transition, and extracellular matrix organization as potential targets of such a chromatin regulation mechanism in colorectal cancer stem cells. Overall, our findings provide novel insights on the role of G9a as a driver of cancer stem cell phenotype, promoting self-renewal, tumorigenicity, and undifferentiated state.
The effectiveness of the Guy’s Rapid Diagnostic Clinic (RDC) in detecting cancer and serious conditions in vague symptom patients
Authors: Dolly Saoirse Olivia , Jones Geraint , Allchorne Paula , Wheeler Daniel , Ali Sunnyath , Mukadam Yaseen , Zheng Sifan , Rahman Loay , Sindhar Jan , Moss Charlotte Louise , Harari Danielle , Van Hemelrijck Mieke , Cunliffe Anthony , De Michele Luigi Vincenzo
Published: January 2021

Background

Rapid Diagnostic Clinics (RDC) are being expanded nationally by NHS England. Guy’s RDC established a pathway for GPs and internal referrals for patients with symptoms concerning for malignancy not suitable for a site-specific 2WW referral. However, little data assessing the effectiveness of RDC models are available in an English population.

Methods

We evaluated all patients referred to Guy’s RDC between December 2016 and June 2019 (n = 1341) to assess the rate of cancer diagnoses, frequency of benign conditions and effectiveness of the service.

Results

There were 96 new cancer diagnoses (7.2%): lung (16%), haematological (13%) and colorectal (12%)—with stage IV being most frequent (40%). Median time to definitive cancer diagnosis was 28 days (IQR 15–47) and treatment 56 days (IQR 32–84). In all, 75% were suitable for treatment: surgery (26%), systemic (24%) and radiotherapy (14%). Over 180 serious non-neoplastic conditions were diagnosed (35.8%) of patients with no significant findings in two-third of patients (57.0%).

Conclusions

RDCs provide GPs with a streamlined pathway for patients with complex non-site-specific symptoms that can be challenging for primary care. The 7% rate of cancer diagnosis exceeds many 2WW pathways and a third of patients presented with significant non-cancer diagnoses, which justifies the need for rapid diagnostics. Rapid Diagnostic Centres (RDCs) are being rolled out nationally by NHS England and NHS Improvement as part of the NHS long-term plan. The aim is for a primary care referral pathway that streamlines diagnostics, patient journey, clinical outcomes and patient experience. This pilot study of 1341 patients provides an in-depth analysis of the largest single RDC in England. Cancer was diagnosed in 7% of patients and serious non-cancer conditions in 36%—justifying the RDC approach in vague symptom patients.