bluuebunny/crossref_metadata_2025 huggingface dataset:
SARS-CoV-2 Infection in Cities from the Southern Region of Bahia State, Brazil: Analysis of Variables Associated in Both Individual and Community Level
Authors: da Silva Murillo Ferreira , dos Santos Uener Ribeiro , Ferreira Fabrício Barbosa , Albuquerque George Rego , Mariano Ana Paula Melo , Fehlberg Hllytchaikra Ferraz , Santos de Santana Íris Terezinha , dos Santos Pérola Rodrigues , Santos Luciano Cardoso , Silva de Jesus Laine Lopes , Piton Karoline Almeida , Costa Beatriz Santos , Gomes Beatriz Sena Moreira , Porto Vinicius Moreira , Oliveira Emanuelly da Silva , Oliveira Cibele Luz , Fontana Renato , Maciel Bianca Mendes , Silva Mylene de Melo , Marin Lauro Juliano , Gadelha Sandra Rocha
Published: July 2023

The COVID-19 pandemic, caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), challenged public health systems worldwide. Individuals in low-income countries/regions are still at individual and community risk concerning inequality, sanitation, and economic conditions. Besides, during the pandemic, the transmission in municipalities and communities in the countryside and less developed regions kept viral spread and required structured and strengthened clinical and laboratory surveillance. Here, we present an observational, analytic, cross-sectional study conducted using secondary data from the Laboratório de Farmacogenômica e Epidemiologia Molecular (LAFEM)-Universidade Estadual de Santa Cruz (UESC), to evaluate individual and community factors associated to SARS-CoV-2 infection in outpatients from different cities from Southern Region of Bahia State, in Brazil. The data were collected between June 2021 and May 2022. The SARS-CoV-2 positivity by RT-qPCR was correlated with low socio-economic indicators, including the Human development index (HDIc) and Average worker salary (AWSc). Besides, in general, females were less likely to test positive for SARS-CoV-2 (OR = 0.752; CI 95% 0.663–0.853; p < 0.0001), while brown individuals had more positivity for infection (p < 0.0001). In addition, those who had clinical symptoms were more likely to test positive for SARS-CoV-2 (OR = 6.000; CI 95% 4.932–7.299; p < 0.0001). Although dry cough, headache, and fever were the most frequent, loss of taste (OR = 5.574; CI 95% 4.334–7.186) and loss of smell (OR = 6.327; CI 95% 4.899–8.144) presented higher odds ratio to be positive to SARS-CoV-2 by RT-qPCR. Nonetheless, the distribution of these characteristics was not homogenous among the different cities, especially for age and gender. The dynamic of SARS-CoV-2 positivity differed between cities and the total population and reinforces the hypothesis that control strategies for prevention needed to be developed based on both individual and community risk levels to mitigate harm to individuals and the health system.
How Infection and Vaccination Are Linked to Acute and Chronic Urticaria: A Special Focus on COVID-19
Authors: Kocatürk Emek , Muñoz Melba , Elieh-Ali-Komi Daniel , Criado Paulo Ricardo , Peter Jonny , Kolkhir Pavel , Can Pelin , Wedi Bettina , Rudenko Michael , Gotua Maia , Ensina Luis Felipe , Grattan Clive , Maurer Marcus
Published: July 2023

Since more than a century ago, there has been awareness of the connection between viral infections and the onset and exacerbation of urticaria. Our knowledge about the role of viral infection and vaccination in acute and chronic urticaria improved as a result of the COVID-19 pandemic but it has also highlighted knowledge gaps. Viral infections, especially respiratory tract infections like COVID-19, can trigger the onset of acute urticaria (AU) and the exacerbation of chronic urticaria (CU). Less frequently, vaccination against viruses including SARS-CoV-2 can also lead to new onset urticaria as well as worsening of CU in minority. Here, with a particular focus on COVID-19, we review what is known about the role of viral infections and vaccinations as triggers and causes of acute and chronic urticaria. We also discuss possible mechanistic pathways and outline the unmet needs in our knowledge. Although the underlying mechanisms are not clearly understood, it is believed that viral signals, medications, and stress can activate skin mast cells (MCs). Further studies are needed to fully understand the relevance of viral infections and vaccinations in acute and chronic urticaria and to better clarify causal pathways.
Begomovirus–Host Interactions: Viral Proteins Orchestrating Intra and Intercellular Transport of Viral DNA While Suppressing Host Defense Mechanisms
Authors: Breves Sâmera S. , Silva Fredy A. , Euclydes Nívea C. , Saia Thainá F. F. , Jean-Baptiste James , Andrade Neto Eugenio R. , Fontes Elizabeth P. B.
Published: July 2023

Begomoviruses, which belong to the Geminiviridae family, are intracellular parasites transmitted by whiteflies to dicotyledonous plants thatsignificantly damage agronomically relevant crops. These nucleus-replicating DNA viruses move intracellularly from the nucleus to the cytoplasm and then, like other plant viruses, cause disease by spreading systemically throughout the plant. The transport proteins of begomoviruses play a crucial role in recruiting host components for the movement of viral DNA within and between cells, while exhibiting functions that suppress the host’s immune defense. Pioneering studies on species of the Begomovirus genus have identified specific viral transport proteins involved in intracellular transport, cell-to-cell movement, and systemic spread. Recent research has primarily focused on viral movement proteins and their interactions with the cellular host transport machinery, which has significantly expanded understanding on viral infection pathways. This review focuses on three components within this context: (i) the role of viral transport proteins, specifically movement proteins (MPs) and nuclear shuttle proteins (NSPs), (ii) their ability to recruit host factors for intra- and intercellular viral movement, and (iii) the suppression of antiviral immunity, with a particular emphasis on bipartite begomoviral movement proteins.
A Review of Climate Adaptation Impacts and Strategies in Coastal Communities: From Agent-Based Modeling towards a System of Systems Approach
Authors: Lawyer Carly , An Li , Goharian Erfan
Published: July 2023

Global warming and climate variations are expected to alter hydrologic conditions and exacerbate flooding, primarily through increasingly frequent and intense storm events and sea-level rise. The interactions between coastlines and their inhabitants around the world are highly diverse, making them challenging to model due to the non-homogeneous, nonlinear, and complex nature of human decision-making. Agent-based modeling has proven valuable in various fields, enabling researchers to explore various social phenomena and emergent patterns under different institutional frameworks, including climate change scenarios and policy decisions, particularly at local scales. This approach is particularly useful in providing insights into possible outcomes and feedback resulting from the convergence of individual- and community-level adaptation decisions, and it has increasingly been used to model coastal systems. However, there are a limited number of studies that examine the effects of climate adaptation decisions on coastal tourism systems. This paper aims to address this gap by first providing an overview of the current state of agent-based modeling literature that explores coastal community adaptation responses to climate change. Subsequently, the paper argues for the application of these methods to simulate the effects of adaptation on coastal tourism dynamics. To better capture the interactions within subsystems and potential redistributed effects inherent in multi-scale and multi-stakeholder decision-making processes within these systems, we propose integrating agent-based modeling with a novel system of socio-environmental systems (SoSES) approach. This integration aims to assist city planners, policymakers, stakeholders, and attraction managers in effectively assessing adaptation options to safeguard their communities from the multifaceted impacts of climate change.
Experimental Study of Roughness Reduction of Large Aqueducts in the Middle Route of the South-to-North Water Diversion Project
Authors: Cui Wei , Chen Wenxue , Mu Xiangpeng , Xiong Qilin , Li Junqiang , Li Xiaochen , Liu Zhe , Zhang Zheqi
Published: July 2023

The roughness of the aqueduct in the Middle Route of the South-to-North Water Diversion Project has increased due to factors such as the natural aging of concrete and biological attachment. To increase the flow capacity of the project, a roughness reduction test was carried out in April 2021 by installing a nano-rubber coating on the Fangshui River aqueduct, which consists of three aqueduct bodies arranged in parallel. Before and after the test, as well as two years after the test, three field observations were conducted. The analysis revealed that compared to aqueduct body 2, which was only cleaned of surface attachments, after excluding the difference in the background roughness, the nano-rubber coating reduced the roughness of aqueduct body 1 by 0.0013 (10.00%). After two years of operation, the roughness was 0.0010 (7.41%) lower, indicating that the nano-rubber coating had a good and lasting effect on the roughness reduction. The roughness field observation results are sensitive to flow rate and water level measurement errors. For aqueducts with a low head and a high flow rate similar to those of the Fangshui River aqueduct, non-contact measuring instruments should be preferentially utilized, and sufficiently accurate flow rate measurements should be ensured to improve the accuracy of the roughness calculation.
Intensity–Duration–Frequency Curves for Dependent Datasets
Authors: El Hannoun Wafaa , Boukili Makhoukhi Anas , Zoglat Abdelhak , El Adlouni Salah-Eddine
Published: July 2023

Intensity–duration–frequency (IDF) curves of precipitation are a reference decision support tool used in hydrology. They allow the estimation of extreme precipitation and its return periods. Typically, IDF curves are estimated using univariate frequency analysis of the maximum annual intensities of precipitation for different durations. It is then assumed that the annual maxima of different durations are independent to simplify the parameter estimation. This strong hypothesis is not always verified for every climatic region. This study examines the effects of the independence hypothesis by proposing a multivariate model that considers the dependencies between precipitation intensities of different durations. The multivariate model uses D-vine copulas to explore the intraduration dependencies. The generalized extreme values distribution (GEV) is considered a marginal model that fits a wide range of tail behaviors. An illustration of the proposed approach is made for historical data from Moncton, in the province of New Brunswick (Eastern Canada), with climatic projections made through three scenarios of the Representative Concentration Pathway (RCP).
Assessment of Water Reclamation and Reuse Potential in Bali Province, Indonesia
Authors: Widianingtias Mitria , Kazama Shinobu , Benyapa Sawangjang , Takizawa Satoshi
Published: July 2023

Bali Province, Indonesia, experiences serious water shortages and groundwater over-abstraction due to rapidly increasing water demand. Therefore, this study aimed to assess the potential for water reclamation and reuse in Bali Province, focusing on the operational performance of two wastewater treatment plants (WWTPs). Although the Suwung WWTP could increase its treatment capacity to produce reclaimed water for irrigation and landscape, there are multiple management issues to be addressed, including fluctuating water demand, limited customer base beyond hotels, concerns about water quality and safety, and cultural perceptions of reclaimed water. In addition, despite the organic loading rates being lower than the design value, the treatment performance of the Suwung WWTP was found to be significantly lower than that of the ITDC WWTP, which achieved high BOD, COD, and TSS removal rates by performing good maintenance of aerators and post-treatment based on dissolved air flotation (DAF). Causal loop analysis indicates that aerator malfunctioning causes multiple problems, such as low dissolved oxygen, poor BOD removal, sludge carryover, and low sludge concentrations. Therefore, regular maintenance of aerators, as well as the development of aerators robust against malfunctioning, are fundamental to producing effluents from stabilization ponds that meet the requirements for irrigation and landscape reuse.
Studi Daya Dukung Stabilisasi Tanah Lempung Menggunakan Campuran Abu Kayu
Authors: Pristianto Hendrik , Rokhman Rokhman , Irman Irman
Published: July 2023

In highway construction work requires a strong and stable subgrade. But in reality the subgrade that is often encountered is subgrade with low support, so it does not meet the requirements when used for road pavement construction. One way to overcome this problem is to do stabilization, namely by using an additive in the form of wood ash. The purpose of this study was to identify how much influence wood ash had on the CBR value of the soil. This research is expected to provide information regarding the feasibility of soil stabilization in Sorong City by using wood ash from wood waste so that it can be used appropriately. For this reason, it is necessary to conduct a study on the use of wood burning residues as a stabilizing material and is expected to increase the carrying capacity of the soil. This research will be carried out by means of stabilization with variations in the mixture content of 3%, 6%, 9%, 12% and 15%. The type of soil that will be used in this study comes from Jalan Moyo, East Sorong District, Sorong City. Next will be testing specific gravity, atterberg limit, compaction test and CBR on each variation of mixing. The results of this study indicate that stabilization of clay soil using wood ash can increase the bearing capacity of the soil, namely where the CBR value of the original soil is 7.32%, which increases with each addition of the percentage of wood ash content.
Strategic analysis of a Mexican public university
Authors: ULLOA-PIMIENTA Ana Ruth , RAMÍREZ-MENESES Aurora , SOBERANO-MAYO María Isabel , SÁNCHEZ-TRINIDAD Rosa del Carmen
Published: July 2023

Educational organizations constantly face changes that must be faced strategically to achieve their objectives and remain competitive, it is the great importance that strategic management represents in organizations, since it allows better decisions to be made. The present investigation is carried out in a public university in the State of Tabasco, Mexico with the objective of analyzing the procedures that contribute to strengthening the management in the direction of the educational institution from a strategic approach. In it, are integrated: analysis of the environment and internal of the University taking into account processes and quality standards in higher education themselves that have been determined in the university environment. The methodology used was descriptive of documentary type and the systematic analysis of information obtained by evaluation matrices in the corresponding areas. The results found highlight the technological and labor weaknesses of the educational institution, great opportunities are recognized for it, some strategies are determined that could be developed taking into account the capacity of the university, the demands of the environment and the educational competitiveness of the market.
Sur le toponyme Gasteiz: origine et signification
Authors: Iglesias Hector
Published: July 2023

L’auteur explique pourquoi le nom basque de la capitale administrative de la Communauté autonome du Pays Basque, c’est-à-dire Gasteiz, ne peut être manifestement rien d’autre qu’un anthroponyme d’origine germanique, wisigothique notamment, formation anthroponymique apparaissant également en Gascogne et dans la patronymie française.
Evaluation of the relative allelic load of mutations of resistance to ibrutinib in the BTK gene by allele-specific PCR in patients with progression of CLL
Authors: Likold E. B. , Biderman B. V. , Fevraleva I. S. , Severina N. A. , Dmitrieva E. A. , Petrenko A. A. , Nikitin E. A. , Sudarikov A. B.
Published: July 2023

Introduction. Currently, Ibrutinib is one of the most effective drugs for relapsed and refractory chronic lymphocytic leukemia treatment. In most patients with CLL, ibrutinib causes persistent remissions, but in some patients the disease progresses. Ibrutinib resistance in most cases is associated with the C481S mutation, which corresponds to the c.1441T>A and c.1442G>C substitutions in the BTK gene, however, other variants also exist.

Aim — to evaluate variable allele fraction of the BTK gene mutations in patients with relapsed chronic lymphocytic leukemia using the in-house allele-specific real-time PCR test.

Materials and methods. The study included material from 102 cases: 39 CLL patients with disease progression on ibrutinib therapy, 24 CLL patients with disease progression on the FCR/FCR-lite protocols, and 38 CLL treatment-naive patients. The control group included 118 patients with non-neoplastic hematological diseases.

Results. Using in-house using AS-PCR, we detected the c.1442G>C mutation in 20 out of 39 CLL patients with progression on ibrutinib therapy. Mutation c.1442G>T was detected in 2 patients. In a single patient, two mutations were detected simultaneously: c.1441T>A and c.1442G>C. Another single patient had a combination of three mutations: c.1442G>C, c.1442G>T and c.1442G>A. In 15 patients with progression on ibrutinib therapy, mutations in the BTK gene were not detected. In treatment-naive CLL patients, in the group treated with FCR/FCR-lite regimens, and in the control group of patients with nonneoplastic diseases, mutations in the BTK gene were not detected.

Conclusion. Variable allele fraction of exon 15 BTK gene mutations in the patients with CLL progression was successfully determined using in-house AS-PCR test: 50 % of patients had one mutation, 5 % had two mutations, and 2.5 % had three mutations in the BTK gene. Timely detection of these mutations before clinical recurrence may facilitate effective treatment strategy. Since clinical manifestations of ibrutinib resistance appear after an average of 1–2 years, we suggest monitoring BTK mutation load every 3 months in patients with CLL before relapse during treatment with ibrutinib.
Supplement intravenous iron therapy in cardiac surgery
Authors: Stepin A. V.
Published: July 2023

Introduction. Preoperative anemia which is present in 25–40 % of cardiac surgery patients increases the risk of adverse postoperative outcomes leading to higher medical expenses. The tendency to restrict allogenic transfusion rate has led to the search for new pharmacological solutions to correct anemia in the perioperative period, nevertheless the usage of intravenous iron preparations in cardiac surgery is still not a generally accepted standard of treatment.

Aim — review of the literature about the effects of perioperative intravenous iron therapy on the clinical outcomes in cardiac surgery.

Main findings. The use of intravenous iron preparations during the perioperative period in cardiac surgery results in better hemoglobin dynamics, iron repletion and less demand for allogenic transfusions. Anemia correction and lower transfusion rate might improve surgery outcomes such as mortality, intensive care unit length of stay and hospital length of stay. Iron repletion, regardless of presence of anemia, might improve the results of 6-minute walk test and patients’ quality of life after surgery. The optimal time for intravenous iron therapy in cardiac surgery is 10–14 days before surgery or immediately after the intervention. Ferric carboxymaltose can be administered in a single injection/infusion shortly before or after surgery.
Acute lymphoblastic leukemias in twins
Authors: Valiev T. T. , Volkova A. S. , Osipova I. V.
Published: July 2023

Introduction. Identical twins are a unique model that can be used to assess the concordance of various diseases, including acute leukemia. It should be noted that acute leukemia is characterized with high concordance in cases of monovular twins or placentas adhesion, which confirms the model of development of this disease in the prenatal period.

Aim — to present a clinical case of successful diagnosis and treatment of acute lymphoblastic leukemia in identical twins.

Main findings. Clinical cases demonstrate the development of common-variant of B-cell precursor acute lymphoblastic leukemia in identical twins with three months interval. The disease course of one of the brothers was characterized by relapses, but treatment with highly effective protocols usage achieved 15-year remission without allogeneic stem cell transplantation. In case of second twin, disease-free life expectancy is 22 years.
Generative Pre-Trained Transformers, Natural Language Processing and Artificial Intelligence and Machine Learning (AI/ML) in Software Vulnerability Management: automations in the Software Bill of Materials (SBOM) and the Vulnerability-Exploitability eXchange (VEX)
Authors: Radanliev Petar
Published: July 2023

One of the most burning topics in cybersecurity in 2023 will undoubtedly be the compliance with the Software Bill of Materials. Since the US president issued the Executive Order 14028 on Improving the Nation’s Cybersecurity, software developers have prepared and bills are transmitted to vendors, customers, and users, but they don’t know what to do with the reports they are getting. In addition, since software developers have identified the values of the Software Bill of Materials, they have been using the reports extensively. This article presents an estimate of 270 million requests per month, just from form one popular tool to one vulnerability index. This number is expected to double every year and a half. This simple estimate explains the urgency for automating the process. We propose solutions based on artificial intelligence and machine learning, and we base our tools on the existing FAIR principles (Findable, Accessible, Interoperable, and Reusable). This methodology is supported with a case study research and Grounded theory, for categorising data into axis, and for verifying the values of the tools with experts in the field. We showcase how to create, and share Vulnerability Exploitability eXchange data, and automate the Software Bill of Materials compliance process with AI models and a unified computational framework combining solutions for the following problems: (1) the data utilisation problem, (2) the automation and scaling problem, (3) the naming problem, (4) the alignment problem, (5) the pedigree, and provenance problem, and many other problems that are on the top of mind for many security engineers at present. The uptake of these findings will depend on collaborations with government and industry, and on the availability and the ease of use of automated tools. 
A Study on the Footprints of Rainfall Pattern for a Sustainable Climate
Authors: - Uma G , - Sneha Babu R
Published: July 2023

A study on rainfall is a comprehensive summary of existing literature and research related to this meteorological phenomenon. In this century, Limiting and adapting to climate change is the subject of one among seventeen Sustainable Development Goals (SDG 13 or Global Goal 13). The United Nations General Assembly created 17 Sustainable Development Goals in 2015. Take immediate action to mitigate climate change and its effects, according to the goal's stated mission statement. SDG 13 and SDG 7 on clean energy are interconnected and mutually supportive. Recent articles and research study provide a critical analysis of the current knowledge on rainfall and its various aspects, including the processes that generate precipitation, the factors that influence rainfall patterns, the impact of climate change on rainfall, and the methods used to measure and forecast rainfall.Reviews on rainfall serve as a valuable resource for scientists, researchers, and policymakers interested in understanding and managing the effects of rainfall on different aspects of society, such as agriculture, water resource management, and disaster mitigation. The study overviews on rainfall pattern among the different states of India, emphasizing their importance, scope, and contributions to the field of meteorology and offer insights into the latest advances in the field and highlight areas where further research is needed.Overall, review on rainfall are an essential tool for synthesizing and consolidating knowledge on this critical aspect of the Earth's climate system, providing a foundation for informed decision-making and policy development.
सोमनाथ होर (1921-2006) की जीवन यात्रा का सारांश एंव ‘आन्नदरूप घोष‘ द्वारा साक्षात्कार का संपूर्ण विवरण
Authors: - Mithun Kumar Dutta
Published: July 2023

सोमनाथ होर जीवनभर एक ही विषय के विस्तारक रहे। जख्म, दुर्भिक्ष, मानवीय यातना, दुःखों का अन्तहीन सिलसिला। शायद खुद को अभिव्यक्त करने की अन्तहीन चाह तड़पन और बैचनी ने उन्हें एक माध्यम से निकलकर दूसरे माध्यम में जाने की प्रेरणा दी। राजनैतिक अस्थिरता, देश विभाजन, युद्ध एवम् दुर्भिक्ष ने उनके मानसपटल पर गहरी छाप छोड़ी जो दशकों तक विभिन्न रूपों में उनके कलाकर्मों में दिखाई पड़ती है। इन अनुभवों की ठोस दृश्यात्मक अभिव्यक्ति ने ही सोमनाथ होर को तकनीकी प्रयोगोें के लिए उकसाया, प्रिंटमेकिंग एंव मूर्तिशिल्प जैसे विरोधाभासी आयामों में काम का प्रदर्शन निश्चित ही सोचने योग्य है। मूर्तिशिल्पों की प्रेरणा के लिए प्रिटमेकिंग (लोरिलीफ पेपर पल्प प्रिंट) ही आपका माध्यम बना जिसमें टेक्टाइल गुण देखने को मिलता है। परम्परागत तौर तरिकों को त्यागकर किये गये ये प्रयोग सिर्फ मूर्तिशिल्प में माध्यम की जटिलता की वजह से ही नहीं बल्कि विषयों की चरम अभिव्यक्ति को ध्यान रख कर भी किये गये। सोमनाथ होर की सम्पूर्ण कला यात्रा प्रयोगों का अटूट-अनुबन्ध है जो तमाम रास्ते खत्म हो जाने के बाद भी, सम्भावनाओं के नये दरवाजे खोलती हैं। जहाँ विषयों का बार-बार दोहराव भी बेहद उद्देश्यात्मक है। इस प्रकार सोमनाथ होर के मूर्तिशिल्प समकालीन कला जगत में तकनीकों के आधुनिक प्रयोगों का दर्पण है, जिससे आगे आने वाली पीढ़ी प्रेरणा लेती रहेंगी।
THE IMPACT OF FINANCIAL PERFORMANCE, FIRM SIZE AND CAPITAL STRUCTURE ON FIRM VALUE
Authors: Suyanto Suyanto , Bilang Chintya N
Published: July 2023

This study aims to prove the effect of financial performance, company size and capital structure on firm value. The sample in the study was 144 manufacturing companies listed on the Indonesia Stock Exchange (IDX) for the 2018-2021 period. The research sample was obtained by purposive sampling technique. The analytical method used is multiple linear regression analysis using SPSS version 23. The results of this research prove that financial performance has a positive effect on firm value, firm size has a positive effect on firm value and capital structure simultaneously has a positive effect on firm value.Keywords: Financial performance, company size, capital structure, firm value
PROBLEM FOR A HYPERBOLIC FRACTIONAL EQUATION WITH THE NON-DEGENERATE INTEGRAL BOUNDARY CONDITIONS
Authors: Koulinté A. , Edoh A. , Bangan S. , Zakari D.M.
Published: July 2023

In this work, we consider a hyperbolic fractional problem with non-degenerate integral boundary conditions. By using the method of Faedo-Galerkin, we demonstrate the existence of a solution of the considered problem by passing to the limit. A new result is given by proving the uniqueness of the solution based on assumptions for a similar problem.
ORGANIZING CLASS MEETING FOR PRIMARY STUDENTS IN VIETNAM WITH THE APPROACH OF LEARNING THROUGH PLAY
Authors: Thi Thu Hang, Dr. Nguyen , Dieu Ngoc Bui Thi , Ngoc Linh Nguyen
Published: July 2023

In Vietnamese primary schools, class meeting is usually held in the last period of the school week. It is included in the collective activities of students at school. Class meeting plays an important role, both helping students to recognize and evaluate learning and training activities during the week, as well as an opportunity to students continue to participate in practice and educational activities organized in the topic. Class meeting helps to build a positive learning environment, build morals and qualities for students, contribute to building a class collective of solidarity, compassion, care, sharing and helping each other. Learning through play is an educational approach that encourages students to develop creativity, interaction, and autonomy. This helps build important skills such as logical thinking, communication and problem solving. By organizing activities with this approach, students are engaged in an active learning environment. Students can experience a fun and exciting learning process that creates social interaction and connections between students and teachers. Reality shows that primary school teachers in Vietnam have been actively implementing teaching innovation and experiential activities. Many teachers have also included fun activities in their lessons but most of these activities are only shown in game organization activities. Teachers do not have an overview and exploit many benefits from all types of learning through play in teaching hours and experiential activities, especially in class meeting.
Diarrea Congenita por Cloruros en un Recien Nacido en un Hospital de Arabia Saudita. Reporte de un Caso (Baish General Hospital, Jazan, Ksa)
Authors: Ramirez Vazquez Erismel , Benítez Aguilar Iliana , Castellano Cid. Dairien Alberto
Published: July 2023

En el presente trabajo se exponen los antecedentes prenatales, perinatales y posnatales de un lactante de 6 meses de edad, del sexo masculino, con clorhidiarrea congénita, así como el cuadro clínico, diagnóstico y tratamiento utilizado. Un elemento significativo lo constituyó la expulsión anal de abundante líquido no meconial desde las primeras horas de nacido, así como alcalosis metabólica grave y la presencia de desnutrición rápidamente progresiva. En los exámenes complementarios se constató hipocloremia de un 50 % con respecto a las cifras de referencia y un pH sanguíneo mayor de 7,50. El diagnóstico confirmatorio se obtuvo al comprobar concentraciones de cloro en heces fecales superiores a las de la suma de sodio y potasio. Se proponen indicadores diagnósticos prenatales entre los que tienen gran valor la consanguinidad, el polihidramnios y los resultados del ultrasonido en el tercer trimestre del embarazo. El diagnóstico precoz permitió establecer el tratamiento y evitó el frecuente desenlace fatal. Es el primer caso de esta enfermedad que se informa en el país.
Estrategia Educativa a partir del Modelo Educativo Tpack en Proyectos de la Carrera de Nutrición
Authors: Mora Poveda Pablo , Varela León Olman Jose
Published: July 2023

El modelo TPACK hace una reflexión acerca de los conocimientos que se deben tener para la integración de las TIC en la práctica educativa de forma eficaz, la investigación es de tipo cuantitativa, descriptiva, participan en total 64 estudiantes regulares de la Universidad Hispanoamericana, como instrumento se aplica un cuestionario de 27 preguntas, mediante Microsoft Office Forms 365, para verificar si existen cambios en los aprendizajes al aplicar el modelo TPACK. Como parámetro estadístico se utiliza la “t” Student. Se obtiene una diferencia estadística entre ambos grupos (T<=t) una cola 0.04 entre ambos grupos del curso Administración de Consultorio al utilizar herramientas tecnológicas al crear el documento plan de empresa y que los estudiantes puedan comprender el impacto en la vida diaria, fomentando así mejor el proceso de conocimiento – aprendizaje, según esta investigación se refleja que al hacer uso de la estrategia TPACK en el uso de las diferentes herramientas tecnológicas utilizadas en los diferentes contenidos, se logra comprender el impacto de aprendizaje universitario en la vida diaria como profesionales integrales en la creación del documento de plan de empresa.
The Transcription Factor RXRα in CD11c+ APCs Regulates Intestinal Immune Homeostasis and Inflammation
Authors: Manoharan Indumathi , Shanmugam Arulkumaran , Ramalingam Malarvizhi , Patel Nikhil , Thangaraju Muthusamy , Ande Satyanarayana , Pacholczyk Rafal , Prasad Puttur D , Manicassamy Santhakumar
Published: July 2023

APCs such as dendritic cells and macrophages play a pivotal role in mediating immune tolerance and restoring intestinal immune homeostasis by limiting inflammatory responses against commensal bacteria. However, cell-intrinsic molecular regulators critical for programming intestinal APCs to a regulatory state rather than an inflammatory state are unknown. In this study, we report that the transcription factor retinoid X receptor α (RXRα) signaling in CD11c+ APCs is essential for suppressing intestinal inflammation by imparting an anti-inflammatory phenotype. Using a mouse model of ulcerative colitis, we demonstrated that targeted deletion of RXRα in CD11c+ APCs in mice resulted in the loss of T cell homeostasis with enhanced intestinal inflammation and increased histopathological severity of colonic tissue. This was due to the increased production of proinflammatory cytokines that drive Th1/Th17 responses and decreased expression of immune-regulatory factors that promote regulatory T cell differentiation in the colon. Consistent with these findings, pharmacological activation of the RXRα pathway alleviated colitis severity in mice by suppressing the expression of inflammatory cytokines and limiting Th1/Th17 cell differentiation. These findings identify an essential role for RXRα in APCs in regulating intestinal immune homeostasis and inflammation. Thus, manipulating the RXRα pathway could provide novel opportunities for enhancing regulatory responses and dampening colonic inflammation.
Asynchronous Online Discussion Forums: Effective Undergraduate and Graduate Course Approaches
Authors: Robbins Eric , Fairbank James
Published: July 2023

Asynchronous online discussion (AOD) can provide an interactive educational experience through formation of learning communities that enable students to develop professional knowledge and critical thinking skills as they engage with colleagues and instructors. We find significant differences between undergraduate and graduate student perceptions of the efficacy of AOD. In this paper, we explore the pedagogical benefits of AOD and describe considerations that guide how they are designed and managed effectively and efficiently. Additionally, we report the results of a survey that measures student perceptions of the extent to which AOD provided a positive educational experience and contributed to their learning.
Approaches to the development of the dendritic cell and neoantigen-based antitumor vaccines
Authors: Bugaev-Makarovskiy NA , Ershov PV , Volkova AG , Makarova AS , Keskinov AA
Published: July 2023

Malignant neoplasms occupy a leading place among non-communicable diseases based on the number of patients and mortality rate. There are several fundamental approaches to cancer therapy, however, none of them are universal or show a high level of clinical response. Furthermore, all the approaches are characterized by a large number of adverse side effects. Today, immunotherapy used alone or in combination with other therapies is considered to be the most promising. Immunotherapy is usually the use of specific antibodies (immune checkpoint inhibitors) or special bioproducts, such as dendritic cells and artificially synthesized peptides, such as neoantigens . The review considers strategies for development of the dendritic cell- and neoantigen-based anticancer vaccines, the possibilities of their improvement and the efficacy of combining with other anticancer drugs. The summary of current clinical trials of the dendritic cell and neoantigen vaccines is provided along with a brief analysis of the basic strategies, achievements and challenges faced by the developers of such vaccines.
PERFIL LOCACIONAL DA SOJA: UM ESTUDO DAS MESORREGIÕES PARANAENSES PARA OS ANOS DE 2000, 2010 E 2020 / SOYBEAN LOCATION PROFILE: A STUDY OF THE REGIONS OF PARANÁ STATE FOR THE YEARS 2000, 2010 AND 2020
Authors: Benevides Ferreira Raiane , Staback Daiane
Published: July 2023

A cultura da Soja sempre esteve presente na composição da atividade produtiva do estado Paraná (Brasil). Com uma produção crescente, o Paraná se consolidou como segundo maior produtor de Soja em grãos do país. Deste modo, o objetivo deste estudo foi analisar se existe concentração espacial e/ou especialização na produção de Soja das mesorregiões do estado do Paraná, para os anos de 2000, 2010 e 2020. Para tanto, utilizou-se o método da análise regional para estimar o quociente locacional (QL), o coeficiente de localização (CL), o coeficiente de redistribuição (CR) e o coeficiente de especialização (CE), e identificar se prevalece algum padrão de concentração e/ou especialização regional na produção de Soja e se houve, ao longo do tempo, mudanças significativas no padrão espacial de localização. Constatou-se que não existe um padrão de concentração espacial e especialização da Soja. No Paraná, a sua produção é distribuída entre as regiões de modo semelhante as demais culturas.
Abstract : Soybean culture has always been present in the composition of the productive activity of the state of Paraná (Brazil). With a growing production, Paraná has consolidated itself as the second-largest producer of soybeans in the country. Thus, the objective of this study was to examine whether there is spatial concentration and/or specialization in the production of Soy in the mesoregions of the state of Paraná, for the years 2000, 2010 and 2020. To this end, the method of regional analysis was used to estimate the locational quotient (LQ), the location coefficient (LC), the redistribution coefficient (RC) and the specialization coefficient (SP), and to identify whether any pattern of regional concentration and/or specialization prevails in Soybean production and whether there were, over time, significant changes in the spatial pattern of location. It was found that there is no pattern of spatial concentration and specialization of Soy. In Paraná, its production is distributed among the regions similarly to other crops.
DINÂMICA DO DESENVOLVIMENTO SOCIOECONÔMICO DOS MUNICÍPIOS DA REGIÃO DA AMARP EM SANTA CATARINA -BRASIL / THE DYNAMICS OF SOCIOECONOMIC DEVELOPMENT OF MUNICIPALITIES IN THE AMARP REGION IN SANTA CATARINA-BRAZIL
Authors: Nogueira Duarte Vilmar
Published: July 2023

Este artigo analisou a dinâmica do desenvolvimento socioeconômico dos municípios integrantes da Associação dos Municípios do Alto Vale do Rio do Peixe - AMARP - SC entre os anos de 2005 e 2016. Para a análise dos municípios adotou-se o Índice Firjan de Desenvolvimento Municipal (IFDM) e como parâmetro metodológico o “Informe sobre Desarrollo Humano” publicado no México em 2002, o qual classifica os municípios em: a) tendendo ao crescimento; b) tendendo ao desenvolvimento; c) círculo vicioso; e d) círculo virtuoso. A análise foi realizada em duas etapas. A primeira mostra a dinâmica da população, do emprego formal e do IFDM dos municípios de abrangência da AMARP. A segunda utiliza duas abordagens analíticas: a intrarregional, que compara o IFDM de cada município da AMARP com a média própria da região; e a inter-regional, que compara o IFDM de cada município da região com a média do estado catarinense como um todo. Os resultados mostram uma melhor condição de desenvolvimento socioeconômico dos municípios da região quando comparados com a média da própria região, ao contrário de quando comparados com a média estadual, em que as desigualdades municipais são mais evidentes, com um elevado número de municípios na condição de subdesenvolvimento.
Abstract : This article analyzed the dynamics of the socioeconomic development of the municipalities that are part of the Association of Municipalities of Alto Vale do Rio do Peixe - AMARP - SC between the years 2005 and 2016. For the analysis of the municipalities, the Firjan Index of Municipal Development (IFDM) was adopted and as a methodological parameter the “Informe sobre Desarrollo Humano” published in Mexico in 2002, which classifies municipalities in: a) tending to growth; b) tending to development; c) vicious circle; and d) virtuous circle. The analysis was carried out in two stages. The first shows the dynamics of population, formal employment and IFDM in the municipalities covered by AMARP. The second uses two analytical approaches: the intraregional one, which compares the IFDM of each municipality in the AMARP with the average for the region; and the interregional one, which compares the IFDM of each municipality in the region with the average for the state of Santa Catarina as a whole. The results show a better condition of socioeconomic development of the municipalities in the region when compared with the average of the region itself, as opposed to when compared with the state average, where municipal inequalities are more evident, with a high number of municipalities in the status of underdevelopment.
Characterisation of a self-sustained, water-based condensation particle counter for aircraft cruising pressure level operation
Authors: Weber Patrick , Bischof Oliver F. , Fischer Benedikt , Berg Marcel , Hering Susanne , Spielman Steven , Lewis Gregory , Petzold Andreas , Bundke Ulrich
Published: July 2023

Abstract. Aerosol particle number concentration measurements are a
crucial part of aerosol research. Vertical profile measurements and
high-altitude/low-pressure performance of the respective instruments become
more important for remote sensing validation and a vital tool for the
observation of climate variables. This study tests the new, commercially
available water condensation particle counter (MAGIC 210-LP) for the
deployment at aircraft cruising pressure levels that the European research
infrastructure IAGOS (In-service Aircraft for a Global Observing System;
http://www.iagos.org, last access: 2 May 2023) is aiming for by operating measurement instrumentation onboard passenger aircraft. We conducted laboratory experiments for conditions
to simulate passenger aircraft flight altitude at operation pressure. We
demonstrate that this type of water condensation particle counter shows
excellent agreement with a butanol-based instrument used in parallel. A
Faraday cup aerosol electrometer serves as the reference instrument.
Experiments are performed with test aerosol ammonium sulfate and fresh
combustion soot at pressure levels ranging from 700 to 200 hPa. For soluble particles like ammonium sulfate, the 50 % detection efficiency cut-off diameter (D50) is around 5 nm and does not differ significantly for all
performed experiments. For non-soluble fresh soot particles, the D50
cut-off diameter of approximately 10 nm does not vary substantially as a
function of pressure, whereas the 90 % detection efficiency cut-off
diameter D90 increases from 19 nm at 700 hPa to 37 nm at 200 hPa. The overall counting efficiency for particles larger than 40 nm reaches 100 % for working pressures of 200 hPa and higher.
A Review on Eulophia nuda Immunomodulatory activity in Peritoneal macrophages and an assessment of its in-vivo activity in mice
Authors: R. Thakre Komal , Paithnakar V. V. , Vyas J. V. , Wankhade A. M.
Published: July 2023

The purpose of this review is to highlight the findings of research on immunomodulatory activity of eulophia nuda tubers. Taxonomically, the genus Eulophia and the genus Dioscorea are represented in Amarkand. Pharmacologically, this plant has cytotoxic, antioxidant, antiglycation, and DNA protective activities. The selection of papers was made using the most relevant databases for the pharmacological activity on the basis of their phytochemical constituents. The review also goes over different in-vitro assay techniques and animal study conformation. The effect of Eulophia nuda extracts on the release of mediators such as nitric oxide (NO), superoxide, lysosomal enzyme, and myeloperoxidase activity of isolated murine peritoneal macrophages was studied at different doses. Eulophia nuda extracts were tested biochemically, hematologically, serologically, and histopathologically. The effect of eulophia nuda extracts on delayed-type hypersensitivity (DTH), serum antibody response, and cyclophosphamide-induced myelosuppression in Swiss albino mice was studied. The current work reviews the histopathological, biological, and statistical analysis of eulophia nuda extract on animal models.
Metanephric adenoma managed with robotic partial nephrectomy: A case report
Authors: W Holck Hailey , E Hall Mary , Weida Carol , P Roy Ornob
Published: July 2023

Introduction: Metanephric adenomas (MAs) are clinically uncommon, with less than 200 cases previously documented. Preoperatively, MAs are difficult to diagnose due to the similarity of imaging characteristics with renal cell carcinomas. Even though MAs are benign tumors, they require careful consideration and treatment. We report a case of a MA managed via active surveillance followed by partial nephrectomy.

Case Report: After presenting for abdominal pain, a 1.3 cm left renal mass was diagnosed in a 58-year-old woman. Active surveillance was initially used to manage the mass for 2 years, at which point she elected for robotic partial nephrectomy. Final histopathological diagnosis was MA.

Conclusion: Preoperative diagnosis of MA is difficult as it shares many characteristic similarities with renal cell carcinomas. It is important for Urologists to be aware of MA as a diagnostic possibility. As awareness and understanding of MA increase, and diagnostic strategies continue to improve, active surveillance strategies may be increasingly utilized in management. If surgical extirpation is ultimately required, partial nephrectomy is a successful and reasonable approach
Analysis of Factors Affecting Employee Productivity (Study on the Employee of PT Arkan Teknik Medan)
Authors: Niken Wulandari
Published: July 2023

The purpose of this study is to determine the effect of compensation on work productivity, to determine the effect of the work environment on work productivity and to determine the effect of compensation and work environment on work productivity at PT. Arkan Field Engineering. The sampling technique in this study used saturated sampling. namely the determination of a sample of 48 respondents who are employees of the production department at PT Arkan Teknik Medan. This research method was collected through questionnaires that were processed and analyzed using data analysis and Multiple Regression. Then conducting a data quality test used is a validity test using Corrected Item Total and a reability test using Cronbach Alpha to test the hypothesis in this study. Researchers use the t test, and the F test and conduct a determination test. The results of this study showed that there was a significant positive influence of compensation variables on work productivity variables indicated by counting (4,520) > ttabel (1.68) with a significance value of 0.000< 0.05, and there was a significant positive influence of work environment variables on work productivity variables shown by counting (3.713) > ttabel (1.68) with a significance value of 0.001< 0.05, and for compensation and a positive work environment and  significant work productivity of employees at  PT Arkan Teknik Medan with a calculated value (109,040) > Ftabel (3.19) with a signification rate of 0.000. Furthermore, the R Square value obtained was 0.829 indicating about 82.9% significant influence of compensation and working environment.