bluuebunny/crossref_metadata_2025 huggingface dataset:
Interrogation of Phenotypic Plasticity between Epithelial and Mesenchymal States in Breast Cancer
Authors: Bhatia Sugandha , Monkman James , Blick Tony , Pinto Cletus , Waltham Mark , Nagaraj Shivashankar H , Thompson Erik W
Published: June 2019

Dynamic interconversions between transitional epithelial and mesenchymal states underpin the epithelial mesenchymal plasticity (EMP) seen in some carcinoma cell systems. We have delineated epithelial and mesenchymal subpopulations existing within the PMC42-LA breast cancer cell line by their EpCAM expression. These purified but phenotypically plastic states, EpCAMHigh (epithelial) and EpCAMLow (mesenchymal), have the ability to regain the phenotypic equilibrium of the parental population (i.e., 80% epithelial and 20% mesenchymal) over time, although the rate of reversion in the mesenchymal direction (epithelial-mesenchymal transition; EMT) is higher than that in the epithelial direction (mesenchymal-epithelial transition; MET). Single-cell clonal propagation was implemented to delineate the molecular and cellular features of this intrinsic heterogeneity with respect to EMP flux. The dynamics of the phenotypic proportions of epithelial and mesenchymal states in single-cell generated clones revealed clonal diversity and intrinsic plasticity. Single cell-derived clonal progenies displayed differences in their functional attributes of proliferation, stemness marker (CD44/CD24), migration, invasion and chemo-sensitivity. Interrogation of genomic copy number variations (CNV) with whole exome sequencing (WES) in the context of chromosome count from metaphase spread indicated that chromosomal instability was not influential in driving intrinsic phenotypic plasticity. Overall, these findings reveal the stochastic nature of both the epithelial and mesenchymal subpopulations, and the single cell-derived clones for differential functional attributes.
Laboratory Compaction Study and Mechanical Performance Assessment of Half-Warm Mix Recycled Asphalt Mixtures Containing 100% RAP
Authors: Marcobal José , Lizárraga José , Gallego Juan
Published: June 2019

The use of low-carbon and energy-efficient paving technologies is gaining worldwide acceptance in recent years as a means to encourage commitment towards more sustainable pavement management practices. However, there still remain some technical gaps regarding mix design procedures for the half-warm mix asphalt (HWMA) mixtures’ preparation and characterization in the laboratory. To this end, three different laboratory compaction methods (e.g., static load, Marshall impactor, and gyratory compactor) were selected and put into assessment to define the most suitable compaction test method for half-warm mix recycled asphalt (HWMRA) mixtures with 100% reclaimed asphalt pavement (RAP). Posteriorly, the effect of four-accelerated curing treatments (0, 24, 48, and 72 h) on the mixtures’ mechanical performance was investigated. Then, advanced mechanical characterization of the mixture performance was conducted to quantify the indirect tensile strength (ITS), stiffness modulus, rutting, and four-point bending (4PB) fatigue test. Thus, based on the authors’ findings, the HWMRA mixtures with 100% RAP and emulsified bitumen exhibited proper volumetric (e.g., air voids and density) and mechanical behavior in terms of moisture damage, ITS, stiffness modulus, rutting, and fatigue cracking. These findings encourage greater confidence in promoting the use of these sustainable asphalt mixes for their use in road pavements or urban streets.
Study on Tensile Properties of CFRP Plates under Elevated Temperature Exposure
Authors: Yang Yongxin , Jiang Yanju , Liang Hongjun , Yin Xiaosan , Huang Yue
Published: June 2019

Elevated temperature exposure has a negative effect on the performance of the matrix resin in Carbon Fiber Reinforced Plastics (CFRP) plates, whereas limited quantitative research focuses on the deteriorations. Therefore, 30 CFRP specimens were designed and tested under elevated temperatures (10, 30, 50, 70, and 90 °C) to explore the degradations in tensile properties. The effect of temperature on the failure mode, stress-strain curve, tensile strength, elastic modulus and elongation of CFRP plates were investigated. The results showed that elevated temperature exposure significantly changed the failure characteristics. When the exposed temperature increased from 10 °C to 90 °C, the failure mode changed from the global factures in the whole CFRP plate to the successive fractures in carbon fibers. Moreover, with temperatures increasing, tensile strength and elongation of CFRP plates decreases gradually while the elastic modulus shows negligible change. Finally, the results of One-Way Analysis of Variance (ANOVA) show that the degradation of the tensile strength of CFRP plates was due to the impact of elevated temperature exposure, rather than the test error.
Progress on Electrolytes Development in Dye-Sensitized Solar Cells
Authors: Iftikhar Haider , Sonai Gabriela Gava , Hashmi Syed Ghufran , Nogueira Ana Flávia , Lund Peter David
Published: June 2019

Dye-sensitized solar cells (DSSCs) have been intensely researched for more than two decades. Electrolyte formulations are one of the bottlenecks to their successful commercialization, since these result in trade-offs between the photovoltaic performance and long-term performance stability. The corrosive nature of the redox shuttles in the electrolytes is an additional limitation for industrial-scale production of DSSCs, especially with low cost metallic electrodes. Numerous electrolyte formulations have been developed and tested in various DSSC configurations to address the aforementioned challenges. Here, we comprehensively review the progress on the development and application of electrolytes for DSSCs. We particularly focus on the improvements that have been made in different types of electrolytes, which result in enhanced photovoltaic performance and long-term device stability of DSSCs. Several recently introduced electrolyte materials are reviewed, and the role of electrolytes in different DSSC device designs is critically assessed. To sum up, we provide an overview of recent trends in research on electrolytes for DSSCs and highlight the advantages and limitations of recently reported novel electrolyte compositions for producing low-cost and industrially scalable solar cell technology.
Effect of the Application of the Global Lung Initiative 2012 Spirometry Reference Equation on the Diagnosing and Classifying Degree of Airway Obstruction in Thai Adults Aged 40 to 80 Years Old
Authors: Chaiwong Warawut , Pothirat Chaicharn , Liwsrisakun Chalerm , Phetsuk Nittaya , Bumroongkit Chaiwat , Deesomchok Athavudh , Theerakittikul Theerakorn , Limsukon Atikun
Published: June 2019

Background and objective: Changing to a different spirometry reference equation can result in misinterpretation of spirometric findings. Currently, there is limited data about any discordance between the interpretations of airway obstruction (AO) using the Global Lungs Initiative (GLI) 2012 and the currently employed Thai reference equations (Siriraj) in Thai adults. Therefore, this study aimed to determine differences in diagnosis around AO and classification of the severity of AO using the GLI2012 and Siriraj reference equations in Thai adults. Materials and Methods: We analyzed spirometric results from Thai adults aged 40–80 years old (n = 2084), which were collected at the Lung Health Center, Maharaj Nakorn Chiang Mai Hospital, Chiang Mai, Thailand between January 2005 and December 2015. The diagnoses concerning the AO were interpreted using the GLI2012 and Siriraj reference equations. The severity of AO in each case was classified into five grades, including mild, moderate, moderately severe, severe, or very severe. McNemar’s test was used to analyze differences in diagnosis of AO and classification of the level of severity. The Kappa statistic was used to determine agreements of diagnosis of AO and classification of severity between the two reference equations. Results: There were significant differences in both diagnosis of AO and their classifying severity level between the two reference equations (p-value < 0.001). However, the levels of agreement between the two reference equations were moderate to very good in different age and sex groups (Kappa values ranged from 0.62 to 0.78 for the diagnosis of AO and 0.54 to 0.89 for the classification of severity). Conclusions: Changing from the Siriraj to the GLI2012 reference equations underestimates the proportion of airway obstruction in Thai adults.
Association between P2X7 Polymorphisms and Susceptibility to Tuberculosis: An Updated Meta-Analysis of Case-Control Studies
Authors: Taheri Mohsen , Sarani Hosna , Moazeni-Roodi Abdolkarim , Naderi Mohammad , Hashemi Mohammad
Published: June 2019

Background and Objectives: Several studies inspected the impact of P2X7 polymorphisms on individual susceptibility to tuberculosis (TB), but the findings are still controversial and inconclusive. To achieve a more precise estimation, we conducted a meta-analysis of all eligible studies on the association between P2X7 polymorphisms and TB risk. Materials and Methods: Relevant studies were identified by searching the PubMed, Web of Science, Scopus and Google scholar databases up to November 2018. Twenty-four full-text articles were included in our meta-analysis. The strength of association between P2X7 polymorphisms and TB risk was evaluated by odds ratios (ORs) and 95% confidence intervals (95% CIs) under five genetic models. Results: The findings of this meta-analysis revealed that the rs3751143 variant significantly increased the risk of TB in heterozygous codominant (OR = 1.44, 95%CI = 1.17–1.78, p = 0.0006, AC vs. AA), homozygous codominant (OR = 1.87, 95% CI = 1.40–2.49, p = 0.0004, CC vs. AA), dominant (OR = 1.50, 95% CI = 1.22–1.85, p = 0.0002, AC + CC vs. AA), recessive (OR = 1.61, 95% CI = 1.25–2.07, p = 0.001, CC vs. AC + AA), and allele (OR = 1.41, 95% CI = 1.19–1.67, p < 0.0001, C vs. A) genetic models. Stratified analysis showed that rs3751143 increased the risk of pulmonary tuberculosis (PTB) and extrapulmonary tuberculosis (EPTB) in all genetic models. Furthermore, the rs3751143 increased risk of TB in the Asian population. The findings did not support an association between the rs2393799, rs1718119, rs208294, rs7958311, and rs2230911 polymorphisms of P2X7 and TB risk. Conclusions: The findings of this meta-analysis suggest that P2X7 rs3751143 polymorphism may play a role in susceptibility to TB in the Asian population. More well-designed studies are required to elucidate the exact role of P2X7 polymorphisms on TB development.
Transient Evolution of Inclusions during Al and Ti Additions in Fe-20 Mass pct Cr Alloy
Authors: Bai Xuefeng , Sun Yanhui , Zhang Yimin
Published: June 2019

The transient evolution of inclusions during Al and Ti additions in a Fe-20 mass pct Cr alloy was investigated using polished cross sections and electrolytic extraction. After Al addition, the evolution of Al2O3-based inclusions based upon the area and particle size passed through the following three main stages with time: Particle agglomeration, inclusion floating, and a slow decrease of the remaining Al2O3-based inclusions. Titanium wire was fed into the steel at the end of the floating stage after Al addition when the Ostwald ripening process was finished. Immediately after Ti addition, the transient phase of Ti oxide was readily generated on the existing Al2O3-based inclusion and disappeared due to Al reduction as time progressed. The formation of the transient TiOx phase was affected by the low disregistry between Al2O3 and TiOx and the local Ti supersaturation, which cannot be predicted by the equilibrium relations of Ti–O–N or Ti–Al–O in the high-Cr-containing melt. Because of the local supersaturation of dissolved [%Ti] and [%N] shortly after Ti addition, TiN associated with existing inclusions and three types of individual TiN including single cubes, twinned inclusions, and clusters were identified. In order to minimize the Ti loss caused by the formation of Ti-rich zones during the transient stages, the removal of large Al2O3-based particles including aggregates, clusters, and flower-shaped inclusions should be promoted by stirring before Ti addition. After Ti addition, Brownian and turbulent were the major factors affecting the collision of particles smaller than the threshold of 2.7 μm. The agglomeration of inclusions larger than this threshold was mainly dominated by turbulent and Stokes’ collisions.
Driving Forces of the Bubble-Driven Tubular Micromotor Based on the Full Life-Cycle of the Bubble
Authors: Lin Yongshui , Geng Xinge , Chi Qingjia , Wang Chunli , Wang Zhen
Published: June 2019

Micromotors show many advantages in practical applications, including small size, large push-to-weight ratio, and low power consumption. Micromotors have been widely used in a variety of applications, including cell manipulation, payload delivery, and removal of toxic components. Among them, bubble-driven micromotors have received great attention due to their large driving force and high speed. The driving force of the bubble-driven micromotor movement comes from the four stages of the life cycle of the bubble: nucleation, growth, slip, and ejection. At present, investigators are still unclear about the driving mechanism of the bubble-driven micromotors, the source of the driving force being still especially controversial. In response to this problem, this paper combines the mass transfer model, hydrodynamic theory, and numerical simulation to explain the driving force generated by the various stages of the life-cycle of the bubble. A mass transfer model was used to calculate the driving force of the motor contributed by the bubble nucleation and slip stage. Based on equilibrium of force and conservation of energy, a theoretical model of the driving force of the tubular micromotor in the growth and ejection stage of the bubble was established. The results show that the driving force contributed by the bubble in the nucleation and the slip stage is rather small. However, the stage of bubble growth and ejection provide most of the driving force. On further evaluating the effect of the bubble driving force on the motor speed, it was found that the growth stage plays a major role in the motion of the bubble-driven micromotor. The micromotor velocity based on the driving forces of the full life-cycle of bubbles agrees well with the experimental results.
Spodumene Flotation Mechanism
Authors: Filippov Lev , Farrokhpay Saeed , Lyo Lichau , Filippova Inna
Published: June 2019

Fine and coarse fractions of spodumene were obtained from a pegmatite ore and their flotation was investigated under different conditions. In particular, the optimum pH and collector dosage were studied. It was found that the best flotation performance occurs at pH 10 using 250 mg/L of sodium oleate. It was also observed that upon the addition of CaCl2, spodumene flotation recovery increases to about 90%. In addition, poor floatability was found for spodumene when Na2CO3 was used as a pH regulator (compared to NaOH).The zeta potential data confirmed the adsorption of oleate on the spodumene surface. It was found that activation of spodumene by calcium ions makes the surface charge less negative due to the adsorption of Ca2+ on the surface. The crystallographic properties of spodumene were analyzed. The adsorption of sodium oleate was attributed to the chemisorption of oleate to the exposed Al and Si sites generated after breakage of the Al–O and Si–O bonds on the mineral surface. It was observed that the {110} planes are the most favorable for the adsorption of oleate. The {110} plane is the weakest plane, and spodumene has the highest tendency to cleave along this plane. The XRD data revealed that fine spodumene particles have more {110} planes than the coarser fraction, which may explain why the former has better floatability.
Synthesis, Crystal Structure, and Biological Evaluation of Fused Thiazolo[3,2-a]Pyrimidines as New Acetylcholinesterase Inhibitors
Authors: Mahgoub Mohamed Y. , Elmaghraby Awatef M. , Harb Abd-Elfttah A. , Ferreira da Silva João L. , Justino Gonçalo C. , Marques M. Matilde
Published: June 2019

A new series of thiazolo[3,2-a]pyrimidine bromide salt derivatives 7a–d were synthesized from 3,4-dihydropyrimidinethione precursors. The target compounds were fully characterized by 1D- and 2D-NMR, high resolution ESI-MS/MS and single crystal X-ray diffraction analysis, which confirmed a regioselective 5H cyclization of the dihydropyrimidinethiones. All target compounds were evaluated in vitro as human acetylcholinesterase (hAChE) inhibitors via an Ellman-based colorimetric assay and showed good inhibition activities (better than 70% at 10 µM and IC50 values in the 1 µM range). Molecular docking simulations for all target products into hAChE were performed and confirmed strong binding to the enzyme. These results provide a promising and new starting point to improve acetylcholinesterase inhibitors and explore novel treatment options against Alzheimer’s disease.
Increasing Silver Nanowire Network Stability through Small Molecule Passivation
Authors: Madeira Alexandra , Plissonneau Marie , Servant Laurent , Goldthorpe Irene A. , Tréguer-Delapierre Mona
Published: June 2019

Silver nanowire (AgNW) transparent electrodes show promise as an alternative to indium tin oxide (ITO). However, these nanowire electrodes degrade in air, leading to significant resistance increases. We show that passivating the nanowire surfaces with small organic molecules of 11-mercaptoundecanoic acid (MUA) does not affect electrode transparency contrary to typical passivation films, and is inexpensive and simple to deposit. The sheet resistance of a 32 nm diameter silver nanowire network coated with MUA increases by only 12% over 120 days when exposed to atmospheric conditions but kept in the dark. The increase is larger when exposed to daylight (588%), but is still nearly two orders of magnitude lower than the resistance increase of unpassivated networks. The difference between the experiments performed under daylight versus the dark exemplifies the importance of testing passivation materials under light exposure.
Evolution of Hair Treatment and Care: Prospects of Nanotube-Based Formulations
Authors: Santos Ana Cláudia , Panchal Abhishek , Rahman Naureen , Pereira-Silva Miguel , Pereira Irina , Veiga Francisco , Lvov Yuri
Published: June 2019

A new approach for hair treatment through coating with nanotubes loaded with drugs or dyes for coloring is suggested. This coating is produced by nanotube self-assembly, resulting in stable 2–3 µm thick layers. For medical treatment such formulations allow for sustained long-lasting drug delivery directly on the hair surface, also enhanced in the cuticle openings. For coloring, this process allows avoiding a direct hair contact with dye encased inside the clay nanotubes and provides a possibility to load water insoluble dyes from an organic solvent, store the formulation for a long time in dried form, and then apply to hair as an aqueous nanotube suspension. The described technique works with human and other mammal hairs and halloysite nanoclay coating is resilient against multiple shampoo washing. The most promising, halloysite tubule clay, is a biocompatible natural material which may be loaded with basic red, blue, and yellow dyes for optimized hair color, and also with drugs (e.g., antilice care-permethrin) to enhance the treatment efficiency with sustained release. This functionalized nanotube coating may have applications in human medical and beauty formulations, as well as veterinary applications.
Molybdenum Disulfide Quantum Dots Prepared by Bipolar-Electrode Electrochemical Scissoring
Authors: Li Yang , Wang Xiaoxia , Liu Mengli , Luo Heng , Deng Lianwen , Huang Lei , Wei Shuang , Zhou Congli , Xu Yuanhong
Published: June 2019

A convenient bipolar-electrode (BPE) electrochemical method was engineered to produce molybdenum disulfide (MoS2) quantum dots (QDs) using pure phosphate buffer (PBS) as the electrolyte and the MoS2 powder as the precursor. Meanwhile, the corresponding by-product precipitate was studied, in which MoS2 nanosheets were observed. The BPE design would not be restricted by the shape and size of the MoS2 precursor. It could lead to the defect generation and 2H → 1T phase variation of the MoS2, resulting in the formation of nanosheets and finally the QDs. The as-prepared MoS2 QDs exhibited high photoluminescence (PL) quantum yield of 13.9% and average lateral size of 4.4 ± 0.2 nm, respectively. Their excellent PL property, low cytotoxicity, and good aqueous dispersion offer promising applicability in PL staining and cell imaging. Meanwhile, the as-obtained byproduct containing the nanosheets could be used as an effective electromagnetic wave (EMW) absorber. The minimum reflection loss (RL) value was −54.13 dB at the thickness of 3.3 mm. The corresponding bandwidth with efficient attenuation (<−10 dB) was up to 7.04 GHz (8.8–15.84 GHz). The as-obtained EMW performance was far superior over most previously reported MoS2-based nanomaterials.
Assessment of Dietary Under-Reporting in Italian College Team Sport Athletes
Authors: Ferraris Cinzia , Guglielmetti Monica , Trentani Claudia , Tagliabue Anna
Published: June 2019

Background: Nutrition is an important factor for sports performance and the assessment of dietary intakes in athletes can correct unhealthy eating habits. However, dietary assessment may be biased due to misreporting. The aim of our study was to investigate the occurrence of misreporting in a sample of collegiate team sport athletes. Methods: A total of 50 athletes participated. Each athlete filled in food records for seven days. Reported energy intake (EI) was considered in relation to the predicted basal metabolic rate (BMR) and expressed as the ratio EI/ BMR. All participants with EI/BMRestd ≤1.23 were classified as “low energy reporters” (LER), and those with an EI/BMRestd ratio >1.23 were classified as “adequate energy reporters” (AER). Results: According to cut-off values for under-reporting, 28 out of 50 athletes (56%) were classified as LER. The LER (16 M/12 F) had significantly higher BMI (23.17 ± 3.46 kg/m2 compared to 21.41 ± 1.91 kg/m2; p = 0.038) than the AER. The EI/kg fat free mass (FFM) was significantly lower in LER than the AER (33.34 ± 6.56 kcal/FFM compared to 48.51 ± 8.59 kcal/FFM, p < 0.0001). Nutrient intake was also significantly different between the two groups. Conclusions: Our results suggest that under-reporting of energy intake by collegiate team sport athletes may occur frequently and needs to be taken into consideration in the interpretation of nutrient intake.
Dietary Composition and Effects in Inflammatory Bowel Disease
Authors: Castro Fernando , de Souza Heitor S. P.
Published: June 2019

Dramatic changes in the environment and human lifestyle have been associated with the rise of various chronic complex diseases, such as inflammatory bowel disease (IBD). A dysbiotic gut microbiota has been proposed as a crucial pathogenic element, contributing to immune imbalances and fostering a proinflammatory milieu, which may be associated with disease relapses or even the initiation of IBD. In addition to representing important regulators of the mucosal immunity and the composition of the gut microbiota, food components have been shown to be potential environmental triggers of epigenetic modifications. In the context of chronic intestinal inflammation, dietary habits and specific food components have been implicated as important modulators of epigenetic mechanisms, including DNA methylation, which may predispose a person to the increased risk of the initiation and evolution of IBD. This review provides novel insights about how dietary factors may interact with the intestinal mucosa and modulate immune homeostasis by shaping the intestinal ecosystem, as well as the potential influence of diet in the etiopathogenesis and management of IBD.
Nutritional Interventions to Improve Clinical Outcomes in Ovarian Cancer: A Systematic Review of Randomized Controlled Trials
Authors: Rinninella Emanuele , Fagotti Anna , Cintoni Marco , Raoul Pauline , Scaletta Giuseppe , Quagliozzi Lorena , Miggiano Giacinto Abele Donato , Scambia Giovanni , Gasbarrini Antonio , Mele Maria Cristina
Published: June 2019

Among all gynaecological neoplasms, ovarian cancer has the highest rate of disease-related malnutrition, representing an important risk factor of postoperative mortality and morbidity. Hence, the importance of finding effective nutritional interventions is crucial to improve ovarian cancer patient’s well-being and survival. This systematic review of randomized controlled trials (RCTs) aims at assessing the effects of nutritional interventions on clinical outcomes such as overall survival, progression-free survival, length of hospital stay (LOS), complications following surgery and/or chemotherapy in ovarian cancer patients. Three electronic bibliographic databases (MEDLINE, Web of Science, and Cochrane Central Register of Controlled Trials) were used to conduct a systematic literature search based on fixed inclusion and exclusion criteria, until December 2018. A total of 14 studies were identified. Several early postoperative feeding interventions studies (n = 8) were retrieved mainly demonstrating a reduction in LOS and an ameliorated intestinal recovery after surgery. Moreover, innovative nutritional approaches such as chewing gum intervention (n = 1), coffee consumption (n = 1), ketogenic diet intervention (n = 2) or fruit and vegetable juice concentrate supplementation diet (n = 1) and short-term fasting (n = 1) have been shown as valid and well-tolerated nutritional strategies improving clinical outcomes. However, despite an acceptable number of prospective trials, there is still a lack of homogeneous and robust endpoints. In particular, there is an urgent need of RCTs evaluating overall survival and progression-free survival during ovarian oncology treatments. Further high-quality studies are warranted, especially prospective studies and large RCTs, with more homogeneous types of intervention and clinical outcomes, including a more specific sampling of ovarian cancer women, to identify appropriate and effective nutritional strategies for this cancer, which is at high risk of malnutrition.
Metabolic Syndrome in Arab Adults with Low Bone Mineral Density
Authors: Wani Kaiser , Yakout Sobhy M. , Ansari Mohammed Ghouse Ahmed , Sabico Shaun , Hussain Syed Danish , Alokail Majed S. , Sheshah Eman , Aljohani Naji J. , Al-Saleh Yousef , Reginster Jean-Yves , Al-Daghri Nasser M.
Published: June 2019

There are discrepancies in the reports on the association of metabolic syndrome (MetS) and its components with bone mineral density (BMD) and hence more population-based studies on this subject are needed. In this context, this observational study was aimed to investigate the association between T-scores of BMD at lumbar L1–L4 and full MetS and its individual components. A total of 1587 participants (84.7% females), >35 years and with risk factors associated with bone loss were recruited from February 2013 to August 2016. BMD was done at L1–L4 using dual-energy X-ray absorptiometry (DXA). T-Scores were calculated. Fasting blood samples and anthropometrics were done at recruitment. Fasting lipid profile and glucose were measured. Screening for full MetS and its components was done according to the National Cholesterol Education Programme Adult Treatment Panel III (NCEP ATP III) criteria. Logistic regression analysis revealed that the odds of having full MetS increased significantly from the lowest T-score tertile to the highest one in both sexes (OR, odd ratio (95% CI, confidence interval) of tertile 2 and 3 at 1.49 (0.8 to 2.8) and 2.46 (1.3 to 4.7), p = 0.02 in males and 1.35 (1.0 to 1.7) and 1.45 (1.1 to1.9), p < 0.01 in females). The odds remained significant even after adjustments with age, body mass index (BMI), and other risk factors associated with bone loss. Among the components of MetS, only central obesity showed a significant positive association with T-score. The study suggests a significant positive association of T-score (spine) with full MetS irrespective of sex, and among the components of MetS this positive association was seen specifically with central obesity.
Dietary Inflammatory Index, Dietary Non-Enzymatic Antioxidant Capacity, and Colorectal and Breast Cancer Risk (MCC-Spain Study)
Authors: Obón-Santacana Mireia , Romaguera Dora , Gracia-Lavedan Esther , Molinuevo Amaia , Molina-Montes Esther , Shivappa Nitin , Hebert James R. , Tardón Adonina , Castaño-Vinyals Gemma , Moratalla Ferran , Guinó Elisabet , Marcos-Gragera Rafael , Azpiri Mikel , Gil Leire , Olmedo-Requena Rocío , Lozano-Lorca Macarena , Alguacil Juan , Fernández-Villa Tania , Martín Vicente , Molina Antonio J , Ederra María , Moreno-Iribas Conchi , Perez Beatriz , Aragonés Nuria , Castello Adela , Huerta José Mª , Dierssen-Sotos Trinidad , Gómez-Acebo Inés , Molina-Barceló Ana , Pollán Marina , Kogevinas Manolis , Moreno Victor , Amiano Pilar
Published: June 2019

Inflammation and antioxidant capacity have been associated with colorectal and breast cancer. We computed the dietary inflammatory index (DII®), and the total dietary non-enzymatic antioxidant capacity (NEAC) and associated them with colorectal and breast cancer risk in the population-based multi case-control study in Spain (MCC-Spain). We included 1852 colorectal cancer and 1567 breast cancer cases, and 3447 and 1486 population controls, respectively. DII score and NEAC were derived using data from a semi-quantitative validated food frequency questionnaire. Unconditional logistic regression models were used to estimate odds ratios (OR) and 95% confidence intervals (95%CI) for energy-adjusted DII (E-DII), and a score combining E-DII and NEAC. E-DII was associated with colorectal cancer risk (OR = 1.93, highest quartile versus lowest, 95%CI:1.60–2.32; p-trend: <0.001); this increase was observed for both colon and rectal cancer. Less pronounced increased risks were observed for breast cancer (OR = 1.22, highest quartile versus lowest, 95%CI:0.99–1.52, p-trend: >0.10). The combined score of high E-DII scores and low antioxidant values were associated with colorectal cancer risk (OR = 1.48, highest quartile versus lowest, 95%CI: 1.26–1.74; p-trend: <0.001), but not breast cancer. This study provides evidence that a pro-inflammatory diet is associated with increased colorectal cancer risk while findings for breast cancer were less consistent.
Design and Synthesis of CNS-targeted Flavones and Analogues with Neuroprotective Potential Against H2O2- and Aβ1-42-Induced Toxicity in SH-SY5Y Human Neuroblastoma Cells
Authors: de Matos Ana M. , Martins Alice , Man Teresa , Evans David , Walter Magnus , Oliveira Maria Conceição , López Óscar , Fernandez-Bolaños José G. , Dätwyler Philipp , Ernst Beat , Macedo M. Paula , Contino Marialessandra , Colabufo Nicola A. , Rauter Amélia P.
Published: June 2019

With the lack of available drugs able to prevent the progression of Alzheimer’s disease (AD), the discovery of new neuroprotective treatments able to rescue neurons from cell injury is presently a matter of extreme importance and urgency. Here, we were inspired by the widely reported potential of natural flavonoids to build a library of novel flavones, chromen-4-ones and their C-glucosyl derivatives, and to explore their ability as neuroprotective agents with suitable pharmacokinetic profiles. All compounds were firstly evaluated in a parallel artificial membrane permeability assay (PAMPA) to assess their effective permeability across biological membranes, namely the blood-brain barrier (BBB). With this test, we aimed not only at assessing if our candidates would be well-distributed, but also at rationalizing the influence of the sugar moiety on the physicochemical properties. To complement our analysis, logD7.4 was determined. From all screened compounds, the p-morpholinyl flavones stood out for their ability to fully rescue SH-SY5Y human neuroblastoma cells against both H2O2- and Aβ1-42-induced cell death. Cholinesterase inhibition was also evaluated, and modest inhibitory activities were found. This work highlights the potential of C-glucosylflavones as neuroprotective agents, and presents the p-morpholinyl C-glucosylflavone 37, which did not show any cytotoxicity towards HepG2 and Caco-2 cells at 100 μM, as a new lead structure for further development against AD.
Co-delivery of D-(KLAKLAK)2 Peptide and Chlorin e6 using a Liposomal Complex for Synergistic Cancer Therapy
Authors: Lim Chaemin , Kang Jin Kook , Won Woong Roeck , Park June Yong , Han Sang Myung , Le Thi ngoc , Kim Jae Chang , Her Jaewon , Shin Yuseon , Oh Kyung Taek
Published: June 2019

Nanotechnology-based photo-chemo combination therapy has been extensively investigated to improve therapeutic outcomes in anticancer treatment. Specifically, with the help of a singlet oxygen generated by the photosensitizer, the endocytosed nanoparticles are allowed to escape from the endosomal compartment, which is currently an obstacle in nanotechnology-based anticancer therapy. In this study, a liposomal complex system (Lipo (Pep, Ce6)), composed of a chlorin e6-conjugated di-block copolymer (PEG-PLL(-g-Ce6)) and a D-(KLAKLAK)2 peptide loading liposome (Lipo (Pep)), was developed and evaluated for its anticancer activity. Due to the membrane lytic ability of the D-(KLAKLAK)2 peptide and the membrane disruptive effect of the singlet oxygen generated from chlorin e6, Lipo (Pep, Ce6) accelerated the disruption of the endosomal compartment, and exhibited strong synergistic anticancer activity in vitro. The prepared liposomal complex system could potentially maximize the efficacy of the nanotechnology-based photo-chemo combination therapy, and can be regarded as a novel, versatile strategy in advanced tumor therapy.
Tensile and Interfacial Loading Characteristics of Boron Nitride-Carbon Nanosheet Reinforced Polymer Nanocomposites
Authors: Vijayaraghavan Venkatesh , Zhang Liangchi
Published: June 2019

The discovery of hybrid boron nitride–carbon (BN–C) nanostructures has triggered enormous research interest in the design and fabrication of new generation nanocomposites. The robust design of these nanocomposites for target applications requires their mechanical strength to be characterized with a wide range of factors. This article presents a comprehensive study, with the aid of molecular dynamics analysis, of the tensile loading mechanics of BN–C nanosheet reinforced polyethylene (PE) nanocomposites. It is observed that the geometry and lattice arrangement of the BN–C nanosheet influences the tensile loading characteristics of the nanocomposites. Furthermore, defects in the nanosheet can severely impact the tensile loading resistance, the extent of which is determined by the defect’s location. This study also found that the tensile loading resistance of nanocomposites tends to weaken at elevated temperatures. The interfacial mechanics of the BN–C nanocomposites are also investigated. This analysis revealed a strong dependency with the carbon concentration in the BN–C nanosheet.
Remote Sensing of Night Lights—Beyond DMSP
Authors: Levin Noam , Kyba Christopher C.M. , Zhang Qingling
Published: June 2019

Remote sensing of night lights differs from other sources of remote sensing in its ability to directly observe human activity from space as well as in informing us on a new type of anthropogenic threat, that of light pollution. This special issue focuses on studies which used newer sensors than the Defense Meteorological Satellite Program - Operational Line-Scan System (DMSP/OLS). Most of the analyses focused on data from the Visible Infrared Imaging Radiometer Suite (VIIRS) nighttime sensor (also called the Day/Night Band, or VIIRS/DNB in short), for which the first instrument in the series was launched in 2011. In this editorial, we provide an overview of the 12 papers published in this special issue, and offer suggestions for future research directions in this field, both with respect to the remote sensing platforms and algorithms, and with respect to the development of new applications.
Two-Dimensional Ship Velocity Estimation Based on KOMPSAT-5 Synthetic Aperture Radar Data
Authors: Back Minyoung , Kim Donghan , Kim Sang-Wan , Won Joong-Sun
Published: June 2019

Continuously accumulating information on vessels and their activities in coastal areas of interest is important for maintaining sustainable fisheries resources and coastal ecosystems. The speed, heading, sizes, and activities of vessels in certain seasons and at certain times of day are useful information for sustainable coastal management. This paper presents a two-dimensional vessel velocity estimation method using the KOMPSAT-5 (K5) X-band synthetic aperture radar (SAR) system and Doppler parameter estimation. The estimation accuracy was evaluated by two field campaigns in 2017 and 2018. The minimum size of the vessel and signal-to-clutter ratio (SCR) for optimum estimation were determined to be 20 m and 7.7 dB, respectively. The squared correlation coefficient R2 for vessel speed and heading angle were 0.89 and 0.97, respectively, and the root-mean-square errors of the speed and heading were 1.09 m/s (2.1 knots) and 17.9°, respectively, based on 19 vessels that satisfied the criteria of minimum size of vessel and SCR. Because the K5 SAR is capable of observing a selected coastal region every day by utilizing various modes, it is feasible to accumulate a large quantity of vessel data for coastal sea for eventual use in building a coastal traffic model.
Monitoring Changes in the Cultivation of Pigeonpea and Groundnut in Malawi Using Time Series Satellite Imagery for Sustainable Food Systems
Authors: Gumma Murali Krishna , Tsusaka Takuji W. , Mohammed Irshad , Chavula Geoffrey , Ganga Rao N. V. P. R. , Okori Patrick , Ojiewo Christopher O , Varshney Rajeev , Siambi Moses , Whitbread Anthony
Published: June 2019

Malawi, in south-eastern Africa, is one of the poorest countries in the world. Food security in the country hinges on rainfed systems in which maize and sorghum are staple cereals and groundnut and pigeonpea are now major grain legume crops. While the country has experienced a considerable reduction in forest lands, population growth and demand for food production have seen an increase in the area dedicated to agricultural crops. From 2010, pigeonpea developed into a major export crop, and is commonly intercropped with cereals or grown in double-up legume systems. Information on the spatial extent of these crops is useful for estimating food supply, understanding export potential, and planning policy changes as examples of various applications. Remote sensing analysis offers a number of efficient approaches to deliver spatial, reproducible data on land use and land cover (LULC) and changes therein. Moderate Resolution Imaging Spectroradiometer (MODIS) products (fortnightly and monthly) and derived phenological parameters assist in mapping cropland areas during the agricultural season, with explicit focus on redistributed farmland. Owing to its low revisit time and the availability of long-term period data, MODIS offers several advantages, e.g., the possibility of obtaining cloud-free Normalized Difference Vegetation Index (NDVI) profile and an analysis using one methodology applied to one sensor at regular acquisition dates, avoiding incomparable results. To assess the expansion of areas used in the production of pigeonpea and groundnut resulting from the release of new varieties, the spatial distribution of cropland areas was mapped using MODIS NDVI 16-day time-series products (MOD13Q1) at a spatial resolution of 250 m for the years 2010–2011 and 2016–2017. The resultant cropland extent map was validated using intensive ground survey data. Pigeonpea is mostly grown in the southern dry districts of Mulanje, Phalombe, Chiradzulu, Blantyre and Mwanza and parts of Balaka and Chikwawa as a groundnut-pigeonpea intercrop, and sorghum-pigeonpea intercrop in Mzimba district. By 2016, groundnut extent had increased in Mwanza, Mulanje, and Phalombe and fallen in Mzimba. The result indicates that the area planted with pigeonpea had increased by 29% (75,000 ha) from 2010–2011 to 2016–2017. Pigeonpea expansion in recent years has resulted from major export opportunities to Asian countries like India, and its consumption by Asian expatriates all over the world. This study provides useful information for policy changes and the prioritization of resources allocated to sustainable food production and to support smallholder farmers.
Coupling Ocean Currents and Waves with Wind Stress over the Gulf Stream
Authors: Shi Qi , Bourassa Mark A.
Published: June 2019

This study provides the first detailed analysis of oceanic and atmospheric responses to the current-stress, wave-stress, and wave-current-stress interactions around the Gulf Stream using a high-resolution three-way coupled regional modeling system. In general, our results highlight the substantial impact of coupling currents and/or waves with wind stress on the air–sea fluxes over the Gulf Stream. The stress and the curl of the stress are crucial to mixed-layer energy budgets and sea surface temperature. In the wave-current-stress coupled experiment, wind stress increased by 15% over the Gulf Stream. Alternating positive and negative bands of changes of Ekman-related vertical velocity appeared in response to the changes of the wind stress curl along the Gulf Stream, with magnitudes exceeding 0.3 m/day (the 95th percentile). The response of wind stress and its curl to the wave-current-stress coupling was not a linear combination of responses to the wave-stress coupling and the current-stress coupling because the ocean and wave induced changes in the atmosphere showed substantial feedback on the ocean. Changes of a latent heat flux in excess of 20 W/m2 and a sensible heat flux in excess of 5 W/m2 were found over the Gulf Stream in all coupled experiments. Sensitivity tests show that sea surface temperature (SST) induced difference of air–sea humidity is a major contributor to latent heat flux (LHF) change. Validation is challenging because most satellite observations lack the spatial resolution to resolve the current-induced changes in wind stress curls and heat fluxes. Scatterometer observations can be used to examine the changes in wind stress across the Gulf Stream. The conversion of model data to equivalent neutral winds is highly dependent on the physics considered in the air–sea turbulent fluxes, as well as air–sea temperature differences. This sensitivity is shown to be large enough that satellite observations of winds can be used to test the flux parameterizations in coupled models.
Raindrop Size Distributions and Rain Characteristics Observed by a PARSIVEL Disdrometer in Beijing, Northern China
Authors: Ji Lei , Chen Haonan , Li Lin , Chen Baojun , Xiao Xian , Chen Min , Zhang Guifu
Published: June 2019

Fourteen-month precipitation measurements from a second-generation PARSIVEL disdrometer deployed in Beijing, northern China, were analyzed to investigate the microphysical structure of raindrop size distribution and its implications on polarimetric radar applications. Rainfall types are classified and analyzed in the domain of median volume diameter D 0 and the normalized intercept parameter N w . The separation line between convective and stratiform rain is almost equivalent to rain rate at 8.6 mm h−1 and radar reflectivity at 36.8 dBZ. Convective rain in Beijing shows distinct seasonal variations in log 10 N w – D 0 domain. X-band dual-polarization variables are simulated using the T-matrix method to derive radar-based quantitative precipitation estimation (QPE) estimators, and rainfall products at hourly scale are evaluated for four radar QPE estimators using collocated but independent rain gauge observations. This study also combines the advantages of individual estimators based on the thresholds on polarimetric variables. Results show that the blended QPE estimator has better performance than others. The rainfall microphysical analysis presented in this study is expected to facilitate the development of a high-resolution X-band radar network for urban QPE applications.
Safety Distance Identification for Crane Drivers Based on Mask R-CNN
Authors: Yang Zhen , Yuan Yongbo , Zhang Mingyuan , Zhao Xuefeng , Zhang Yang , Tian Boquan
Published: June 2019

Tower cranes are the most commonly used large-scale equipment on construction site. Because workers can’t always pay attention to the environment at the top of the head, it is often difficult to avoid accidents when heavy objects fall. Therefore, safety construction accidents such as struck-by often occurs. In order to address crane issue, this research recorded video data by a tower crane camera, labeled the pictures, and operated image recognition with the MASK R-CNN method. Furthermore, The RGB color extraction was performed on the identified mask layer to obtain the pixel coordinates of workers and dangerous zone. At last, we used the pixel and actual distance conversion method to measure the safety distance. The contribution of this research to safety problem area is twofold: On one hand, without affecting the normal behavior of workers, an automatic collection, analysis, and early-warning system was established. On the other hand, the proposed automatic inspection system can help improve the safety operation of tower crane drivers.
Imbibition, Germination, and Early Seedling Growth Responses of Light Purple and Yellow Seeds of Red Clover to Distilled Water, Sodium Chloride, and Nutrient Solution
Authors: Costa  , Dias  , Dias
Published: June 2019

The seeds of red clover are heteromorphic and two color morphs can be visually recognized, light purple and yellow, resulting from heterozygosity and recessive homozygosity at two loci. Here, we report the responses of seed imbibition, seed germination, and early seedling growth of the two morphs to distilled water, sodium chloride, and complete nutrient solution. The sensitivity of red clover seeds to treatments increased with the stage of development in what seems to be a cumulative process. No differences were found in seed imbibition between morphs or between treatments. In seedling growth, on the contrary, treatments were always effective, but differences between morphs were only observed in seeds that were treated with nutrient solution, whereas in the intermediate stage of seed germination, the effects by treatments were observed together with the appearance of differences between morphs in distilled water and in the treatment by sodium chloride solution. Simultaneously, the superior performance of the yellow morph that was found in germination, which appears to be a trait stable across cultivars of red clover seeds, turned into a superior performance of the light purple morph in seedling growth.
Agrobiodiversity Products in Alternative Food System: Case of Finnish Native Cattle Breeds
Authors: Soini Katriina , Pouta Eija , Latvala Terhi , Lilja Taina
Published: June 2019

Agrobiodiversity products i.e., products from native breeds and plant species can make a valuable contribution to a local food market while also maintaining and preserving ecological and cultural values. There have been attempts to create markets for these products, but they continue to be marginal across the world. Previous research revealed how various stakeholders perceive the native breeds and their products. This study applied a transdisciplinary, multi-actor co-production of knowledge approach that is often used in the food system research. The approach aims at improving the understanding of the ecological, regional and social embeddedness of a Finnish native breed, the Finncattle, and at co-creating feasible supply chains for Finncattle products. The study confirmed that the market does not work and the embeddedness may also constitute some challenges for the development of feasible product chains. The study suggested some practical solutions to overcome these challenges. Furthermore, the results revealed some weaknesses of the co-production of knowledge approach used and discussed possible reasons that can be further explored in future research.