bluuebunny/crossref_metadata_2025 huggingface dataset:
Impacts of Water Logging on Soil Microbial Intentions and Mung Bean (Vigna radiata L.) Physiology
Authors:   University of Sargodha, Sargodha 40100, Pakistan, Afzal Abdul Hannan , Zubair Hassan ,   University of Sargodha, Sargodha 40100, Pakistan
Published: January 2024

The mung bean (Vigna radiata L.) is an important pulse crop known for its high protein content and adaptability to tropical and subtropical regions, particularly in Asia. Despite of their importance as a source of protein, most noticeably that, waterlogging negatively affects their growth and yield. Waterlogging, resulting from factors like compacted soil and excessive irrigation, leads to hypoxic conditions and negatively affects various physiological and morphological aspects of mung bean plants. The impact of waterlogging on mung beans at different growth stages emphasises its detrimental effects on root growth, leaf area, chlorophyll content, photosynthesis, and biomass. Waterlogging disrupts nutrient uptake, causing deficiencies and hindering overall plant adaptation. The molecular responses and metabolic changes in mung beans under waterlogging stress can upset the shift to anaerobic metabolism and the synthesis of specific proteins. Microbial interactions in the rhizosphere soil and their influence on mung bean growth during waterlogging also play an important role in mung bean growth and yield. Tolerance mechanisms, including morphological adaptations and physiological changes, are explored, offering insights into selecting tolerant genotypes. Agronomic strategies, such as the use of cytokinin and gibberellin acid used for mitigating waterlogging effects and enhancing mung bean resilience.
A case study on barriers to permanent residence in Korea for international students
Authors:   Global Studeis Education Association, Lee YunJu , Kim MyungKwang
Published: January 2024

The purpose of this study was to examine ways for foreign students to permanently stay in Korea through examples of barriers to their permanent stay in Korea. For this purpose, the circumstances of foreign students' residential stay in Korea were classified into three categories and examined. In-depth interviews were conducted with research participants recruited through snowball sampling, and the collected data were processed according to hermeneutic analysis procedures. As a result of the analysis, 'barriers to job-seeking visa extension', 'barriers to E-7 visa issuance', 'barriers to major-related employment', 'barriers to Korean language and employment education', 'barriers to period of stay', and 'barriers to social security system and accompanying family support'. appear. Based on this, close cooperation between foreign students and the Ministry of Justice, a big data-based AI platform, and an online learning method based on Jeongju Korean were suggested.
An Analysis of Trends in Studies on Territory Education
Authors:   Global Studeis Education Association, Cho Inseong
Published: January 2024

The purpose of this study is to analyze trends in territory education conducted in South Korea from 1996 to 2022. In this study, the collected research works were categorized into the four research types of national land education, global territory education, glocal territory education and Dokdo Island education, and then trends in studies on territory education were explored. Finally, this study proposes academic directions and tasks for future studies on territory education as follows: First, it is necessary to switch the focus of studies on territory education from Dokdo Island education to the other research types of national land education, global territory education, and glocal territory education. Second, in territory education, it is necessary to attempt studies revolving around 'learners,' major subjects in education field or classes, rather than remaining at the level of the analysis of curricula and textbooks or comparison with other countries and thus alienating learners. Third, it is necessary to conduct follow-up studies that reflect and inspect the results and suggestions of studies related to territory education. Fourth, given the low percentage of studies on global territory education, it is judged that these studies will have to be vitalized.
Dosimetric Impact on Bone Marrow Sparing with Dual Energy Vmat in Treatment of Cervical Cancer
Authors: C Shambhavi
Published: January 2024

Background: To investigate the dosimetric impact on bone marrow sparing using VMAT of dual arc using dual energy in treatment of cervical cancer. Methods: Twenty patients with cervical cancer were chosen retrospectively. Bone marrow was contoured to all the cases. Four VMAT (Volumetric Modulated Arc Therapy) plans were generated like Dual Arc (DA) with 6MV energy of x-ray photon, DA with 10MV, DA of dual energy with (6MV and 10MV) and DA of dual energy with (6MV and 15MV) and were optimized using similar planning objectives and dose calculation was done using Monte Carlo algorithm. The dosimetric results were compared to find significance difference using Repeated Measures ANOVA with significance level set at 5%.
The 2023 Updated Classification and Diagnostic Criteria of Mastocytosis
Authors: Hamed Nahla AM
Published: January 2024

Mastocytosis is an uncommon hematologic malignancy characterized by accumulation of abnormal mast cells in various organs or tissues. A somatic point mutation in the KIT gene at codon 816 is detected in more than 90% of patients with systemic Masto cytosis (SM). The 2022 WHO classification continues to recognize three disease types: systemic mastocytosis, cutaneous mastocytosis and mast cell sarcoma. Bone marrow mastocytosis is a new separate subtype of SM. The classification also recognizes well-differentiated systemic mastocytosis, a morphologic pattern that can occur in any SM subtype. Diagnostic criteria for SM have been modified. The expression of CD30 and the presence of any KIT mutation causing ligand-independent activation have been accepted as minor diagnostic criteria. Classical B-findings and C-findings have undergone minor refinements. Most notably, variant allele frequency of D816V mutation ≥ 10% in bone marrow cells or peripheral blood leukocytes is qualified as a B-finding.
Can Magnetic Resonance Urethrography (MRU) be a Single-Stop Shop for Male Urethral Stricture Evaluation?
Authors: Rastogi Rajul
Published: January 2024

Stricture in male urethra is a commonly encountered clinical condition in urological outpatient department. Till recently, all such strictures were being evaluated with Retrograde Urethrography (RGU) to determine the future course of management. But with the advent of plastic surgery, information regarding presence of spongiofibrosis & other associated conditions, in addition to length of stricture is being demanded from radiologist for deciding the mode of management. Hence, this article discusses various imaging modalities for evaluation of male urethral strictures with their merits and demerits in the light of recent medical literature.
Gastric Secretion and Upper Gastrointestinal Endoscopic Findings in End Stage Renal Disease Patients
Authors: Gupta Krishan L
Published: January 2024

Background: Impaired bicarbonate secretion is one of the proposed mechanisms for uremic gastrointestinal symptoms. This prospective case-control study was aimed to determine the effects of uremia on gastric acid and bicarbonate secretion in end stage renal disease (ESRD) patients on maintenance hemodialysis (MHD) and to correlate the bicarbonate secretion with morphological changes in the upper gastrointestinal tract and with the presence of H. pylori.
Urine Biomarkers for the Detection of Clinically Significant Prostate Cancer
Authors: Lanzac A Pérez
Published: January 2024

Prostate cancer (PCa) biomarkers, especially urine-based ones, are useful tools able to improve the diagnosis and management of the disease. They help physicians to determine if a biopsy is required, mainly with prostate-specific antigen (PSA) levels between 4.0 and 10.0ng/mL, and therefore avoid unnecessary biopsies. Urine biomarkers can differentiate a clinically significant PCa and thus guide toward the most appropriate treatment. Diagnostic accuracy of novel urine-based test is higher than PSA level. The present manuscript aims at showing the most complete and updated information about urine-based biomarkers for the detection of clinically significant PCa, i.e. PCA3, SelectMDx, ExoDx Prostate IntelliScore, and Mi‑Prostate score. The literature basing their diagnostic efficacy is extensive in the case of PCA3, however limited for the remaining ones. Long-term, prospective, head-to-head comparisons, and real-world studies are required to complete and corroborate the available results. Besides this, the European Association of Urology has included in their guidelines the use of urine-based tests for deciding whether or not to undergo an initial or repeat biopsy. Further investigations will be the basis for the approval and widely use of these tests in routine clinical practice.
Symptomatic Gartner Duct Cyst in A Newborn: Diagnosis and Management
Authors: Stanislaw Warchol
Published: January 2024

Persistent Gartner Duct cyst is extremely rare in infants. We describe the case of Gartner Duct cyst with ectopic ureteral opening into the cyst and ipsilateral, non-functioning, dysplastic kidney, presenting initially as a large, inter labial cyst causing bladder empting problems and present its management.
Pelestarian Pengetahuan Asli Pande Besi sebagai Sumber Belajar Kimia Unsur Periode IV
Authors: Ismawati Riva , Rahayu Rina , Muna Lutfi Kaedzorotul
Published: January 2024

Ethnoscience is a study that includes original knowledge of the community which can be verified through scientific methods. This original knowledge can be used as a learning resource to provide in-depth experiences, broaden knowledge, and increase students' interest in studying science. The purpose of this research is to reconstruct the original blacksmith's knowledge into scientific knowledge. This study used a qualitative approach with interview and observation methods. The population used in this research is the people of Rejosari Village, Pakis District, Magelang Regency who work as blacksmiths. The focus of research is on the tools and materials used by blacksmiths during the production process. Data analysis uses the Miles-Huberman model which includes data reduction, data presentation, drawing conclusions and verification. Based on the results of the research, a number of conclusions were obtained, including the form of the relevance of original science to period IV chemical elements, so that it could be used as a learning resource. The scientific concepts contained in the original knowledge of blacksmiths include metal elements, electron configurations, metal properties, corrosion, redox reactions, and metal alloys.
Pengembangan “pHelper” Kalkulator pH Larutan Berbasis Web Sebagai Media Pembelajaran Kimia
Authors: Winoto Sebastian Wilbert , Galih Aileen Vitta Budiman , Awahita Himeriko , Irmita Luthfia Ulva
Published: January 2024

In the 21st century and approaching the upcoming Industrial Revolution 5.0, advancements in science education are of paramount importance. Moreover, chemistry and science education in the upcoming Industrial Revolution 5.0 will heavily rely on technology. This research introduces "pHelper," a web-based pH solution calculator designed as an interactive chemistry learning media to address the challenges of advancing chemistry education through technology integration. The research aims to assess the effectiveness of pHelper through validation tests and analyze student responses to this innovative tool. The research methode use is R&D (Research & Development) with ADDIE model (Analysis, Design, Development, Implementation, and Evaluation). The instrument used is in the form of assessment sheet validation test and student responses. The results of the validation test for the pHelper learning media met the valid criteria with a validity of 85.3% and the students' responses to the pHelper learning media met the very good criteria with a value of 87%. By merging technology and chemistry education, this research contributes to the evolution of science learning methodologies in preparation for the imminent Industrial Revolution 5.0 challenges.
Pengembangan Asesmen Formatif Berbasis Problem Based Learning untuk Meningkatkan Keterampilan Berpikir Kritis: Need Assessment Study
Authors: Fahmi Jam'an , Nahadi Nahadi , Hernani Hernani
Published: January 2024

Curriculum, learning, and assessment are the main keys to educational success. Formative assessment is an interactive strategy to identify what must be learned and how teaching is formulated according to educational needs. The questionnaire results show that chemistry teachers in schools still do not utilize formative assessments to measure the progress of the educational process. This research aims to collect information regarding the need for developing formative assessments for problem-based learning to improve students' critical thinking skills in the sub-material of vapor pressure reduction. A qualitative method was used in this research, involving 40 chemistry teacher participants in the province of North Sumatra, Indonesia. Participants were asked questions regarding their views on the need for assessment development through a questionnaire. Several of them were interviewed semi-structured to gain more in-depth information from the questionnaire answers. Data were analyzed using the Miles and Huberman model which consists of the steps: collection, reduction, display, and conclusion. The research results show that teachers agree that PBL-based formative assessments are needed to measure students' critical thinking skills. They suggest researchers choose Ennis's version of critical thinking indicators because they have good detail and warn researchers to practice Problem-Based Learning syntax correctly. Apart from that, it is hoped that successful learning in the classroom can be achieved through the use of products from the development of this formative assessment, namely test instruments and observation sheets.
Pengembangan E-Book Kimia Berbasis Augmented Reality (AR) pada Materi Bentuk Molekul
Authors: Ariska Nasya Nur , Sholeh Moh Ismail , Laksono Pandu Jati
Published: January 2024

This study was motivated by the limited support of engaging media in chemistry learning on molecular shape materials. The material of molecular shape is abstract and requires a medium capable of visualizing the molecular shape clearly and realistically. The technology that aligns with these problems is Augmented Reality. This research aims to observe the validity results of the developed product and to know the student's responses towards the Augmented Reality (AR) Based Chemistry E-book on Molecular Shape Material. This study is an R&D (Research and Development) development study. By using the 4-D development model that was modified into 3 stages; define, design, develop. The validation test of this media is based on assessments from language experts, media experts, and material experts. The product validation results were assessed by media experts by 97%, material experts by 94%, and language experts by 90%, with a very valid category. In addition, a trial was conducted on students to find out the response to the developed media. Based on the assessment results of student responses, a percentage of 89% was obtained on a small scale and 95% on a medium scale with a very good category
Stratégies d’adaptation des élevages bovins sédentaires face à la territorialisation des parcours et aux insuffisances alimentaires au Nord Bénin
Authors: Adedigba Saliou , Diogo Rodrigue Vivien Cao , Dossa Luc Hippolyte , Paul Birthe Katharina
Published: January 2024

Face à l’expansion des terres agricoles, aux insuffisances alimentaires et au programme de sédentarisation des élevages, les systèmes d’élevage bovins au Nord Bénin doivent désormais s’adapter à la variabilité spatiale et temporelle des ressources afin d’assurer la sécurité alimentaire de leur cheptel et la diversification des revenus. La présente étude vise à analyser les stratégies d’adaptation des élevages bovins dans le contexte actuel de sédentarisation et d’insuffisances alimentaires. Ainsi, 280 élevages bovins sédentaires appartenant à trois zones agroécologiques : Gogounou (Zone Cotonnière Nord), Kalale (Zone Vivrière du Sud Borgou) et Tchaourou (Zone Cotonnière Centre) ont fait l’objet d’étude. Les données collectées concernent les facteurs de choix des zones de pâture, les zones de pâturage des animaux et les stratégies d’adaptation aux insuffisances alimentaires. Une analyse factorielle des correspondances multiples (AFCM), suivie d’une classification hiérarchique ascendante, a permis de faire une typologie des stratégies. Trois stratégies d’adaptation ont été identifiées : (i) élevage avec une stratégie d’adaptation basée sur l’agropastoralisme (EAP : 42,5 %) ; (ii) élevage avec une stratégie d’adaptation mixte basée sur la mobilité courte et longue distance avec division du troupeau (EMim : 21,1 %) et (iii) élevage avec une stratégie d’adaptation basée sur la mobilité en zones protégées (EMAP : 36,4 %). La diversité des zones de pâturage, la localisation des éleveurs, le cheptel bovin, l’expansion des zones agricoles, les itinéraires de transhumance et les types d’élevage sont les principaux déterminants des différents groupes de stratégies d’adaptation étudiées (p < 0,05). La culture fourragère constitue la stratégie la plus viable et prometteuse pour assurer l’autonomie alimentaire. L’appropriation aux éleveurs de terres sur lesquelles ils pourront obtenir un droit de propriété serait un grand atout pour promouvoir cette stratégie.
FEM ANALYSIS OF WOODEN JOINTS AND WOODEN STRUCTURE OF THE ELECTRIC CAR’S FRAME
Authors:   Department of Engineering Processes Automation, Integrated Manufacturing Systems, Faculty of Mechanical Engineering, Silesian University of Technology, Gliwice, Poland, Żur Alicja , Żur Paweł ,   Department of Engineering Processes Automation, Integrated Manufacturing Systems, Faculty of Mechanical Engineering, Silesian University of Technology, Gliwice, Poland, Baier Andrzej ,   Prof. PŚ, Department of Engineering Processes Automation, Integrated Manufacturing Systems, Faculty of Mechanical Engineering, Silesian University of Technology, Gliwice, Poland
Published: January 2024

The paper covers the topic of FEM analysis (Finite Element Method) of selected types of wood joints and the analysis of the wooden structure, the electric car in the electric car of the frame of the Silesian Greenpower team. The main assumption of the work was to analyze the displacements and stresses in the structure of the frame that result from the actual load on the structure. Selected wooden joints were analyzed in FEM analysis. The paper also presents various techniques for modelling connections between elements, such as connection by nail or screw, cohesive contact, or the MPC beam element considering three different materials: oak, pine, and plywood. The aim of the study and the final stage was the FEM analysis of the wooden structure, the car frame. The actual support points for the frame and the actual loads on the structure resulting from the mass of components such as the driver, batteries, and motor were taken into account. The distribution and values of stresses in the structure were analysed, as well as the total displacements resulting from the loading of the mass elements, as well as the centrifugal force acting on the car during driving in a corner.
EFFECT OF CRYOGENIC AND NATURAL AGING PROCESS APPLIED TO Al-Zn-Mg-Cu ALLOYS ON LIFE TIME CALCULATION
Authors:   Faculty of Technology, Department of Metallurgical and Materials Engineering, Gazi University, Ankara, Turkey, Altuntaş Gözde , Altuntaş Onur ,   Department of Warfare Weapons and Tools, Alparslan Defense Sciences and National Security Institute, National Defense University, Ankara, Turkey, Bostan Bülent ,   Faculty of Technology, Department of Metallurgical and Materials Engineering, Gazi University, Ankara, Turkey
Published: January 2024

In this study, life time calculation of aluminum 7075 alloy with cryogenic and natural aging processes was performed by thermal analysis. The aluminum alloy was quenched after solid solution treatment at 480°C and naturally aged for 10-100 days at room temperature (25°C). Other samples were cryogenically treated at -40°C and -80°C for 2 hours after solid solution treatment at 480°C. After the cryogenic treatment, natural aging was done at room temperature for 10-100 days. At the end of each period determined for the samples, the hardness values were measured. It was observed that there was no significant change in hardness values at the end of 10 and 100 days at -80 °C. Thus, it was determined that the natural aging process does not start after cryogenic treatment at -80 °C. It was observed that the hardness value of naturally aged samples after cryogenic treatment at -40 °C increased more than the natural aged samples only. This showed that -40 °C improved the mechanism by creating a driving force in the material. Life time calculations between 30 °C and 320 °C also showed that -40 °C cryogenic treatment + natural aging increased life time by approximately 20% compared to natural aging alone.
Implementation of Biorhythm Graph with Trigonometric Functions using Python
Authors:   Student, My Paul School, Goesan, Republic of Korea, Bee Kang Gyu , Ye Won Jeon ,   Student, My Paul School, Goesan, Republic of Korea
Published: January 2024

This study aimed to implement the researcher's biorhythm graph using a programing language called Python in relation to trigonometric functions. The etymology of biorhythm is a combination of two Greek words, Bio, which means life, and Rhythm, which means regular and accurate rhythm, and means the rules of human life rhythm. In other words, the biorhythm is a theory that everyone is governed by three rhythm curves called physical rhythm, emotional rhythm, and intellectual rhythm that start inside the body from birth to death. During this study, biorhythm and trigonometric functions were studied, and biorhythm graphs were implemented with trigonometric functions when the researcher's date of birth was entered through Python. A biorhythm graph was implemented based on Python, the most used programming language. The Python syntax used in the algorithm is typically a sympy function, a datetime function, arrange function, and a function. The value obtained after implementing the algorithm using this grammar is as follows. This is the result of implementing a biorhythm graph using the algorithm implemented by the two researchers. This paper can be used in various fields related to the relationship between biorhythms and trigonometric functions.
TÛTÎ-NÂME’DE KADINLIK VE ERKEKLİK
Authors: ÇULHAOĞLU PİRENCEK Gülşen F.
Published: January 2024

Sanskritçe aslı Çukasaptati olan Tûtî-nâme, papağanın yetmiş hikâyesi anlamına gelir. Tûtî-nâme Farsça’ya çevrilmesiyle birlikte, kültürler arası yolculuğuna başlamış ve 1538 tarihinde Kânûnî Sultan Süleyman’ın emriyle, kesin olmamakla birlikte Eyyûbî tarafından hazırlanan versiyonuyla Türkçeleştirilmiştir. Geniş halk kitlelerinin ilgisine mazhar olan bu metin böylece klasik Türk edebiyatında önemli bir konuma yükselir. Metnin önemi, papağan tarafından anlatılan hikâyeler aracılığıyla verilen öğütlerin, dönemin genel yaşayışına ve ahlâk anlayışına ilişkin bilgiler vermesinden gelir. Metinde kadın-erkek ilişkilerinin değerlendirilişi bilhassa ilginçtir. Bu makalede, Tûtî-nâme adlı eserdeki kadınlık ve erkeklik rolleri, aile ve iffet gibi konular bağlamında ele alınacaktır. Tûtî-nâme gibi farklı kültürlerden izler taşıyan ve bir kültürden diğerine yapılan aktarım ve çevirilerle zenginleşen bir metnin bu odaklarla ele alınması, bu kültürler arasındaki geçişliliği tartışmak, birbirlerine karşıtlık içinde kurulan kadınlık-erkeklik rollerini değerlendirmek ve aile kavramına temel oluşturan değerleri inceleyebilmek için gereklidir.
MEDIA PENDIDIKAN GIZI NUTRITION CARD BERPENGARUH TERHADAP PERUBAHAN PENGETAHUAN MAKANAN JAJANAN ANAK SEKOLAH DASAR
Authors: Wahyuningsih Ni Putu , Nadhiroh Siti Rahayu , Adriani Merryana
Published: January 2024

Less knowledge related to street food among primary schoolchildren is one of problem that need an attention. An effort to tackle that problem is crucial, for example by giving nutrition education through educational media. This research aims to analyze differences in knowledge after intervention with nutrition card and whiteboard. The design study used was quasi experimental with pre test – post test control group. Sample in this study was fifth grade student with 27 primary schoolchildren in each group. Intervention was conducted for 1 month consist of 8 meetings and each meeting was done for over 30 minutes. Based on mann whitney test, result shows that there was a differences in knowledge (P<0,05) after nutrition education with a nutrition card. The conclusion from this study is nutrition card could knowledge about food street among primary schoolchildren. Wider socialization of this type of education is need to be done both in schoolchildren in SDN Keputih 245 as well as other schools.Keywords: nutrition card, nutrition education, primary school children
HUBUNGAN DUKUNGAN SUAMI DAN DUKUNGAN KELUARGA DENGAN PEMBERIAN ASI EKSKLUSIF PADA IBU ANGGOTA KELOMPOK PENDUKUNG ASI (KP-ASI)
Authors: Oktalina Ona , Muniroh Lailatul , Adiningsih Sri
Published: January 2024

Breast milk is the best investment for children’s health and intelligence of. Exclusive breastfeeding is influenced by health behavior factors, one of which is a driving factor including husband and family support that is necessary for mothers to breastfeed exclusively. The purpose of this study was to analyze the relationship between husband and family support with exclusive breastfeeding in breastfed mothers of KP-ASI members in Megaluh Jombang Public Health Center. This study is an observational analytic study with cross sectional design. Sample was breastfed mother who is participant of KP-ASI and had infants aged 6-12 months as much as 74 people selected using purposive sampling method. The data was collected through interview using a questionnaire. The result showed there was a correlation between family support and exclusive breastfeeding behavior (p = 0.011) but there was no correlation between husband support with exclusive breastfeeding behavior (p = 0.090). In conclusion, family support as reinforcing factor can motivate a mother to do exclusive breastfeeding. It is expected that all members of the family can provide support for mother to breastfeed exclusively and cadres can also invite mothers’ family members (parents, husband, siblings) to participate in the counseling (KP-ASI) activity and provide education regarding the importance of exclusive breastfeeding.Keywords: breastfeeding behavior, exclusive breastfeeding, family support, husband support
FREKUENSI KUNJUNGAN POSYANDU DAN RIWAYAT KENAIKAN BERAT BADAN SEBAGAI FAKTOR RISIKO KEJADIAN STUNTING PADA ANAK USIA 3 – 5 TAHUN
Authors: Destiadi Alﬁan , Nindya Triska Susila , Sumarmi Sri
Published: January 2024

Stunting is a chronic nutrition problem that requires precise intervention. Risk factors of stunting are need to be assessed to find the solution, such as attendance rate in integrated health post (posyandu) and weight gain. This was a case control study done in children aged 3-5 years old in Sidoarum village, Godean, Sleman, Yogyakarta. Sampling was done by simple random sampling technique with total 43 respondents in each group. Stunting is categorized based on the value of the z-score of height for age less than -2 SD. Primary data was obtained by interview, while attendance rate in integrated health post and weight gain were obtained through secondary data that is growth monitoring card (KMS) and monthly reports of integrated health post. Statistic test used for bivariate analysis was Chi-square and Multiple Logistic Regression for multivariate analysis. Result of bivariate analysis found that attendance rate in integrated health post and weight gain are related to stunting. Result showed that a low rate of attendance in integrated health post is the most dominant factor for the incidence of stunting in children aged 3-5 years (OR = 3.1, CI 95%= 1,268-7,623). This study concluded that children who are less active to come to integrated health post have 3.1 times higher risk of stunting compared to children who are actively come to integrated health postKeywords: attendance rate in integrated health post, children, stunting, weight gain
TIDAK ADA PERBEDAAN BERAT BAYI LAHIR ANTARA IBU DIABETISI DAN IBU NON-DIABETISI
Authors: Cholidah Emi Nur , Wirjatmadi Bambang
Published: January 2024

Diabetes mellitus is a metabolic multisystem disease characterized by hyperglycemia due to abnormalities in insulin  secretion and/or insulin work. In pregnancy, diabetes mellitus became one of the risk factor for infant’s high birth weight. The other potential factors are mother’sage, pre-pregnancy nutritional status, pregnancy weight gain, gestational age, and parity. Therefore, the research wanted to analyze the difference of birth weight between diabetic mother and non-diabetic mother. Comparative analytical method was used in this study with cross-sectional design.The sample in this study was 10 diabetic mothers and 10 non-diabetic mothers which was taken by simple random sampling in RSU Haji Surabaya. Independendent T-test was used to analyze the birth weight difference. The result showed that the proportion of hight birth weight were more prevalent in diabetic mothers (50%) than non-diabetic mothers (30%). Independent T-test analysis showed there was no difference in birth weight between diabetic mothers and non-diabetic mothers (p= 0,208). Further reseach is needed to understand birth weight determinant factors, particularly in diabetic mothers. Keywords: Birth Weight Infants, Diabetes mellitus, pregnancy, nutritional status
PENGARUH SUBSTITUSI RUMPUT LAUT (EUCHEUMA COTTONII) DAN JAMUR TIRAM (PLEUROTUS OSTREATUS) TERHADAP DAYA TERIMA DAN KANDUNGAN SERAT PADA BISKUIT
Authors: Kesuma Cindhy Pamela , Adi Annis Catur , Muniroh Lailatul
Published: January 2024

Biscuit is a food product made from the basic ingredient ﬂ our that baked until moisture content less than 5%.  Commercial biscuits are generally rich in energy and high in sugars derive from carbohydrates and fats, but low inﬁ ber. Seaweed (Eucheuma cottonii) and arrowroot ﬂ our are high-ﬁ ber food, while oyster mushroom contains high protein so it can be a potential ingredients to be substituted in biscuits. The addition of seaweed and oyster mushroom was expected to increase the ﬁ ber content of biscuits compared to other biscuits. This study aimed to determine the acceptability and improve ﬁ ber content in biscuits with the substitution of seaweed and oyster mushrooms. This study used a completely randomized design (CRD) with 3 treatments and 4 repetitions. Arrowroot ﬂ our substitution treatment,seaweed, and oyster mushrooms were applied as F1 (25%: 50% to 25%), F2 (25%: 45%: 30%), and F3 (25%: 40%: 35%). Acceptability of biscuits based on organoleptic test and ﬁ ber content from calculation based on Indonesia Food Composition Database and also laboratory analysis using proximate test. This research showed that formula 3 had the highest score based on organoleptic test with score 2.86. The highest ﬁ ber content per serving (50 g) was found in formula 1 with 10.59 g of ﬁ ber. The conclusion of this research is that the biscuit with substitution of seaweed andoyster mushroom has a good acceptability and higher ﬁ ber content compared to commercial biscuits.Keywords: biscuit, oyster mushroom (Pleurotus ostreatus), seaweed (Eucheuma cottonii)
Healing Evaluation After Treatment of Vulnus Morsum on Domestic Cat Hind Leg: A Case Report
Authors: I Nyoman Surya Tri Hartaputera  , I Wayan Gorda  , I Wayan Wirata
Published: January 2024

A Vulnus morsum is a term used to describe a wound resulting from an animal bite. Specifically, wounds inflicted by cat bites are referred to as Vulnus morsum felis. A domestic cat named Sinto, approximately one-year-old with a body weight of 2.4 kg was examined with complaints of a torn wound on the right leg after fighting with another cat. The clinical examination results showed that case cat generally had a body condition score of 4/9 with an alert temperament and an attitude that always lowered its tail to protect the wound. Clinical examination also showed a Vulnus morsum on the hind right leg. A complete blood count showed that the cat had leukocytosis, granulocytosis, and thrombocytopenia. From the results of anamnesis, clinical examination, and supporting examinations, the case cat was diagnosed with Vulnus morsum felis with a fausta prognosis. Treatment was carried out by applying three principles of wound care; cleansing, debridement, and wound closure. In addition to surgical procedures, post-surgery antibiotics and anti-inflammatory drugs were given. The wound was treated and cleaned daily using an antiseptic to help the healing process. The wound found in the case cat were healed after surgical procedures and 12 days of treatment.
Collatz Conjecture
Authors: Durmagambetov Asset
Published: January 2024

This paper presents an analysis of the number of zeros in the binary representation of natural numbers. The primary method of analysis involves the use of the concept of the fractional part of a number, which naturally emerges in the determination of binary representation. This idea is grounded in the fundamental property of the Riemann zeta function, constructed using the fractional part of a number. Understanding that the ratio between the fractional and integer parts of a number, analogous to the Riemann zeta function, reflects the profound laws of numbers becomes the key insight of this work. The findings suggest a new perspective on the interrelation between elementary properties of numbers and more complex mathematical concepts, potentially opening new directions in number theory and analysis."
Dissipative Chaotic Itinerancy and the Dirichlet Eta Function
Authors: Oliveira Hime
Published: January 2024

This work presents a new type of chaotic dynamical system originated from Dirichlet Eta function. Although the exposition describes only a bidimensional instance, it is certainly possible to construct higher dimensional such models. The novelty resides in the multitude of interesting characteristics concentrated in only one kind of dynamical system, mainly because of its simple abstract definition - it provokes dissipative, chaotic and itinerant behavior, and its paths typically display nonrecurring quasi-attractors and associate regions of ruin. In addition, it is discrete and nonautonomous, being additively driven by a simple real vector sequence. Also, the defining formulas have parameters which permit to activate bifurcatory effects, mainly related to setting the number of quasi-attractors and overall geometric complexity and diversity. In this fashion, it holds a certain similarity with classical itinerant chaotic systems, but it is a completely different object. One of its parameters is very influential and may be intuitively compared to a type of "potential energy", capable of changing the duration of sojourns etc. In this fashion, there is a potential opportunity to employ artificial inference techniques for designing specific structures on paths. Of course, the other parameters are also relevant, but not necessarily in the control of the number of quasi-attractors and the permanence periods near them. It is important to state that the described system was found during a previous investigation about certain features of the Riemann hypothesis, using the Dirichlet Eta function instead of the Riemann Zeta function - the components of the system under study here were part of certain series whose convergence had to be established, and that scenario produced this very positive side effect. The text also suggests an atypical, but important, potential application in philosophy: the representation of the Hindu concepts of Samsara and Moksha.
Potential of a New Bacteriophage to Control Klebsiella pneumoniae: Preliminary Studies to Control Urinary Tract Infections
Authors: Duarte João , Máximo Carolina , Costa Pedro , Oliveira Vanessa , Gomes Newton CM , Romalde Jesús López , Pereira Carla , Almeida Adelaide
Published: January 2024

Urinary tract infections (UTIs) caused by Klebsiella pneumoniae can lead to severe clinical complications and even death. An alternative treatment option for infected patients is using bacteriophages (phages). In the present study, we isolated phage KP-1 from sewage water using K. pneumoniae as a host. Whole genome analysis indicated that the genome was a double-stranded linear 176,096-bp long DNA molecule with 41.8% GC content and did not contain virulence or antibiotic resistance genes. The inactivation potential of phage KP-1 was assessed in broth at an MOI of 1 and 10, and a maximum inactivation of 4.9 and 5.4 log CFU/mL was observed after 9 h, respectively. The MOI of 10 efficacy was also assessed in urine to evaluate the phage’s performance in an acidic environment. A maximum inactivation of 3.8 log CFU/mL was observed after 9 h. The results indicate that phage KP-1 could be used to control UTIs caused by K. pneumoniae; however, further studies using phage cocktails to broader the phage’s spectrum of activity and phages in micro- or nanocarriers to avoid the negative effect of the low pH of the urine on phage viability, are necessary.
Innovative Approach to Produce Pd-103 for Auger-Emitting Radionuclide Therapy: A Proof-of-Concept Study
Authors: Laouameria Aicha Nour , Hunyadi Mátyás , Csík Attila , Szűcs Zoltán
Published: January 2024

Auger-emitting radionuclides exemplified by Pd-103, exhibit considerable therapeutic potential in cancer treatment due to their heightened cytotoxicity and localized biological impact. Despite these advantages, the separation of such radionuclides presents a complicated challenge, requiring intricate and time-intensive "wet chemistry" methods attributed to the exceptional chemical inertness of the associated metals. This study proposes an innovative solution to this separation challenge through the design and implementation of a radionuclide separation equipment (RSE). The equipment employs a dry distillation approach, capitalizing on differences in partial vapor pressures between irradiated and resulting radioactive metals, with a diffusion-driven extraction method applied to separate Pd-103 radionuclides generated via proton irradiation of Rh-103 at the ATOMKI MGC-20 cyclotron. Optimization endeavors focused on determining the optimal temperature for effective metal separation, adjusting diffusion, evaporation, and deposition rates, as well as addressing chemical impurities. Calculations indicate 17 % ± 2 % separation efficiency with our RSE. Approximately 77% ± 2% and 49% ± 2% of the deposited Pd-103 were isolated on substrates of Nb foil and ZnO-covered W disk, respectively. The proposed innovative dry distillation method that has been experimentally tested, offers a promising alternative to conventional separation techniques, enabling enhanced purity and cost-efficient cancer treatment strategies.
Hands-on Approach to Foster Paludiculture Implementation and Carbon Certification on Extracted Peatland in Latvia
Authors: Stivrins Normunds , Bikše Jānis , Jeskins Jurijs , Ozola Ilze
Published: January 2024

Voluntary carbon markets open horizons for private companies, public institutions, and individuals developing CO2 removal projects in peatlands to reduce overall carbon footprint. These steps, however, should be in line with appropriate rewetting targets. To do so, the base line information about the status of area must be assessed. Here we follow the methodology set by the carbon certification program standards which define the necessary steps for reference conditions assessment. In this study we practically test the fulfilment of necessary drained peatland baseline evaluation for paludiculture and carbon certification activities. Estimates on the greenhouse gas emission mitigation potential were summarized to define priorities and propose quantifiable measures with suggested paludiculture implementation. Our hands-on approach shows that it is possible for companies to implement rewetting strategies without large EU level project fundings when the conservation and economic aspects are met, thus boosting climate mitigation actions.
The Pharmaceutical Industry in 2023. An Analysis of FDA Drug Approvals from the Perspective of Molecules
Authors: De la Torre Beatriz G , Albericio Fernando
Published: January 2024

With the COVID-19 pandemic behind us, the U.S. Food and Drug Administration (FDA) has approved 55 new drugs in 2023, a figure consistent with the number authorized in the last five years (53 per year on average). Thus, 2023 is the second-best FDA harvest after 2018 (59 approvals) in all the series. Monoclonal antibodies (mAbs) continue to be the class of drugs with most approvals, with an exceptional 12, a number that makes it the most outstanding year for this class. As in 2022, five proteins/enzymes have been approved in 2023. However, no antibody–drug conjugate (ADC) has been released onto the market. With respect to TIDES (peptides and oligonucleotides), 2023 has proved a spectacular year, with a total of nine approvals, corresponding to five peptides and four oligonucleotides. Natural products continue to be the best source of inspiration for drug development, with 10 new products on the market. Three drugs in this year’s harvest are pegylated, which may indicate the return of pegylation as a method to increase the half-lives of drugs, after the withdrawal of peginesatide from the market in 2013. Following the trends of recent years, two bispecific drugs have been authorized in 2023. As in preceding years, fluorine and/or N-aromatic heterocycles are present in most of the drugs. Herein, the 55 new drugs approved by the FDA in 2023 are analyzed exclusively on the basis of their chemical structure. They are classified as the following: biologics (antibodies, proteins/enzymes); TIDES (peptide and oligonucleotides); combined drugs; pegylated drugs; natural products; nitrogen aromatic heterocycles; fluorine-containing molecules; and other small molecules.
Hydrocarbon Reservoir Characterization in the Challenging Structural Setting of Southern Gulf of Suez: Synergistic Approach of Well Log Analyses and 2D Seismic Data Interpretation
Authors: Reda Mohamed , Mostafa Taher , Raef Abdelmoneam , Fathy Mohamed , Alshehri Fahad , Ahmed Mohamed
Published: January 2024

The Gulf of Suez is a sedimentary rift-basin with thick evaporites and complex structural settings that presents challenges to achieving quality imaging based on seismic reflection data. Such subsurface settings and the lack of 3D seismic data poses challenges in building reservoir models to guide hydrocarbon exploration and development, especially in southern parts the Gulf of Suez. This study attempts to overcome the challenges of both 2D seismic interpretation and building a static reservoir model of two Miocene reservoir formations, Ras Ghara Field, Southern Gulf of Suez. Integration of well log data analysis of nine wells and regional-tectonics cognizant 2D seismic interpretation of nineteen 2D seismic lines enabled a reliable 3D static reservoir model. The Miocene reservoir characterization reveals heterogeneity in lithofacies distribution, with thick evaporite sequences causing seismic reflection distortions. Significant hydrocarbon accumulations are associated with horst fault blocks. The Miocene reservoirs demonstrate effective porosity of 14-33%, water saturation of 16-65%, and hydrocarbon saturation of 35-84%. Two new prospects are identified based on structure, facies distribution, and petrophysical results, with estimated original oil in place (OOIP) of 2,002,404 stock tank barrels (STB) and 1,175,580 STB for the Kareem Formation, and 6,302,916 STB and 2,841,894 STB for the Rudeis Formation.
Unraveling the Potential of ALK-Targeted Therapies in NSCLC: Comprehensive Insights and Future Directions
Authors: Parvaresh Hannaneh , Roozitalab Ghazaal , Golandam Fatemeh , Behzadi Payam , Jabbarzadeh Kaboli Parham
Published: January 2024

The current review comprehensively explores the multifaceted landscape of anaplastic lymphoma kinase (ALK) and its pivotal role, specifically within non-small cell lung cancer (NSCLC). It traces the trajectory of ALK's discovery, notably its fusion with nucleolar phosphoprotein (NPM)-1 in anaplastic large cell non-Hodgkin's lymphoma (ALCL) in 1994. It unfolds the subsequent impact of ALK gene alterations across various malignancies, including inflammatory myofibroblastoma (IMT) and NSCLC. The prevalence of intricate ALK rearrangements affecting roughly 3–5% of NSCLC patients prompted the approval of six ALK-tyrosine kinase inhibitors (TKIs) by 2022, revolutionizing the treatment landscape for advanced metastatic ALK+ NSCLC. Second-generation TKIs like alectinib, ceritinib, and brigatinib have notably emerged to combat resistance issues initially associated with crizotinib, the pioneer ALK-TKI approval. Moreover, this review delves into the intersection of ALK and immunotherapy, exploring the potential of immune checkpoint inhibitors in ALK-altered NSCLC tumors. Despite promising preclinical data, challenges encountered in trials evaluating combinations like nivolumab-crizotinib, primarily due to severe hepatic toxicity, underscore the need for cautious exploration of these novel approaches. Additionally, the review delves into innovative avenues such as ALK vaccines and biosensors, shedding light on their promising potential within ALK-driven cancers. This comprehensive analysis encompasses molecular mechanisms, therapeutic strategies, and immune interactions associated with ALK-rearranged NSCLC. Ultimately, the review is a pivotal resource guiding future research and therapeutic interventions in ALK-targeted therapy for NSCLC.
Effects of a 10-Week Athletic Performance Program on Match Performance Variables in Professional Football Players
Authors: Jiménez-Rubio Sergio , Estévez Rodríguez José Luis , Escamilla-Galindo Victor Escamilla-Galindo , Jiménez Sáiz Sergio L. , Del Coso Juan
Published: January 2024

The aim of this study was to evaluate the effect of an Athletic Performance Program, performed in addition to teams’ regular training routines, on match performance variables in professional football players. Twenty-nine professional football players (age=27.21±4.95 years; body mass=79.56±5.21 kg) of the Spanish First Division (LaLiga) underwent a 10-week training program focused on the development of mobility, stability, strength, and multidirectional running skills. The APP included 5 indoor sessions per week and on-field micro-dosing stimulus in addition to regular training practices. Match performance variables obtained with GPS devices during official matches and jump performance were measured before and after the APP. The APP increased peak running speed (31.1±1.4 vs 32.1±1.0 km/h, P < 0.001, d=1.88), the number of sprints (0.14±0.03 vs 0.16±0.03 sprint/min, P< 0.001, d=1.44) and the sprint distance (6.45±1.43 vs 8.35±1.22 m/min P< 0.001, d=2.49) during the matches. The intervention also increased countermovement jump height (34.1±2.7vs 35.8±2.5 cm, P< 0.001, d=2.20). The APP was effective to improve intense actions during competitive match play in professional football players. Strength and conditioning coaches may consider the use of multicomponent physical training programs included in the usual training week to enhance players’ match running at high intensity.