bluuebunny/crossref_metadata_2025 huggingface dataset:
Nutritional Status, Dietary Intake and Dietary Diversity of Landfill Waste Pickers
Authors: Swart Elizabeth C. , van der Merwe Maria , Williams Joy , Blaauw Frederick , Viljoen Jacoba M. M. , Schenck Catherina J.
Published: March 2022

The purpose of this study was to investigate and describe the nutritional status, dietary intake and dietary diversity of waste pickers in South Africa, a socioeconomically vulnerable group who makes a significant contribution to planetary health through salvaging recyclable material from dumpsites. Participants were weighed and measured to calculate body mass index (BMI). Dietary intake was recorded using a standardised multipass 24 h recall. Individual dietary diversity scores were derived from the dietary recall data. Data were collected from nine purposefully selected landfill sites located in six rural towns and three cities in four of the nine provinces in South Africa, providing nutritional status information on 386 participants and dietary intake on 358 participants after data cleaning and coding. The mean BMI of the study sample was 23.22 kg/m2. Underweight was more prevalent among males (22.52%) whilst 56.1% of the females were overweight or obese. The average individual dietary diversity score was 2.46, with 50% scoring 2 or less. Dietary intake patterns were characterised as monotonous, starch-based and lacking vegetables and fruits. The nutritional status, dietary intake and dietary diversity of waste pickers reflect their precarious economic status, highlighting the need for health, social and economic policies to improve access and affordability of nutritious food.
Holographic Wide-Angle System for Deformation Measurement of Extended Structures
Authors: Guerra Flavio , Wilhelm Philipp , Haist Tobias
Published: March 2022

We introduce a holographic wide angle system that combines the accuracy of a long focal length with the extended field of view of a wide angle lens. To accomplish this, we use a computer-generated hologram (CGH) in front of the lens to diffract light from (a discrete number of) specific angular locations. This method is tested in laboratory conditions, as well as under real-world conditions. This measurement system was developed as a possible tool for real-time movement tracking and control of extended dynamic structures, such as bridges and high-rise buildings. Within that application, the obtained measurement uncertainty is 10 μm in object space at 10 m distance spanning 10 m width.
Pharmaceutically Active Microbial AhR Agonists as Innovative Biodrugs in Inflammation
Authors: Puccetti Matteo , Pariano Marilena , Costantini Claudio , Giovagnoli Stefano , Ricci Maurizio
Published: March 2022

Alterations of the microbiome occur in inflammatory and autoimmune diseases, a finding consistent with the role of the microbiome in the maintenance of the immune system homeostasis. In this regard, L-tryptophan (Trp) metabolites, of both host and microbial origin, act as important regulators of host–microbial symbiosis by acting as aryl hydrocarbon receptor (AhR) ligands. The intestinal and respiratory barriers are very sensitive to AhR activity, suggesting that AhR modulation could be a therapeutic option to maintain the integrity of the epithelial barrier, which has substantial implications for health even beyond the mucosal site. A number of studies have highlighted the capacity of AhR to respond to indoles and indolyl metabolites, thus positioning AhR as a candidate indole receptor. However, the context-and ligand-dependent activity of AhR requires one to resort to suitable biopharmaceutical formulations to enable site-specific drug delivery in order to achieve therapeutic effectiveness, decrease unwanted toxicities and prevent off-target effects. In this review, we highlight the dual activity of the microbial metabolite indole-3-aldehyde at the host–microbe interface and its ability to orchestrate host pathophysiology and microbial symbiosis and discuss how its proper clinical development may turn into a valuable therapeutic strategy in local and distant inflammatory diseases.
New Synthetic Analogues of Natural Polyphenols as Sirtuin 1-Activating Compounds
Authors: Bononi Giulia , Flori Lorenzo , Citi Valentina , Acciai Cecilia , Nocilla Viviana , Martelli Alma , Poli Giulio , Tuccinardi Tiziano , Granchi Carlotta , Testai Lara , Calderone Vincenzo , Minutolo Filippo
Published: March 2022

NAD+-dependent deacetylase SIRT1 regulates many different biological processes, thus being involved in pathogenic conditions such as metabolic diseases, neurogenerative disorders and cancer. Notably, experimental evidence underlined that the activation of SIRT1 had promising cardioprotective effects. Consequently, many efforts have been so far devoted to finding new SIRT1 activators, both derived from natural sources or prepared by synthetic procedures. Herein, we discovered new SIRT1-activating derivatives, characterized by phenolic rings spaced by sulfur, nitrogen or oxygen-based central linkers. The newly synthesized derivatives were analyzed in enzymatic assays to determine their ability to activate SIRT1, as compared with that of resveratrol. Among the tested molecules, bisarylaniline compound 10 proved to be the most efficient SIRT1 activator. An evaluation of the effects caused by focused structural variations revealed that its para-hydroxy-substituted diphenyl moiety of 10 was the fundamental structural requirement for achieving good SIRT1 activation. Compound 10 was further investigated in ex vivo studies in isolated and perfused rat hearts submitted to ischemia/reperfusion (I/R), where it showed significant protection of the myocardium against I/R injury. Molecular modeling studies suggest the binding mode of 10 within SIRT1 in the presence of the p53-AMC peptide. Our findings reveal that this chemical scaffold may be used as the starting point to develop a new class of more potent SIRT1 activators as cardioprotective agents.
Pioglitazone Synthetic Analogue Ameliorates Streptozotocin-Induced Diabetes Mellitus through Modulation of ACE 2/Angiotensin 1–7 via PI3K/AKT/mTOR Signaling Pathway
Authors: Ahmed Yasmin M. , Abdelgawad Mohamed A. , Shalaby Khaled , Ghoneim Mohammed M. , AboulMagd Asmaa M. , Abdelwahab Nada S. , Hassan Hossam M. , Othman Asmaa M.
Published: March 2022

The renin angiotensin aldosterone system has a localized key regulatory action, especially in liver and body circulation. Furthermore, it accomplishes a significant role in the downregulation of the PI3K/AKT/mTOR signaling pathway that is involved in type II diabetes mellitus pathogenesis. The current study aimed to evaluate the effect of a synthetic pioglitazone analogue (benzenesulfonamide derivative) compared to the standard pioglitazone hypoglycemic drug on enhancing liver insulin sensitivity via ACE 2/Ang (1–7)/PI3K/AKT/mTOR in experimental STZ-induced diabetes. After the model was established, rats were distributed into the normal control group, diabetic group, pioglitazone group (20 mg/kg), and a benzenesulfonamide derivative group (20 mg/kg), with the last 2 groups receiving oral treatment for 14 consecutive days. Our results suggested enhancing liver insulin sensitivity against the ACE2/Ang (1–7)/PI3K/AKT/mTOR pathway. Moreover, the synthetic compound produced a reduction in blood glucose levels, restored hyperinsulinemia back to normal, and enhanced liver glycogen deposition. In addition, it up regulated the ACE2/Ang (1–7)/PI3K/AKT/mTOR signaling pathway via increasing insulin receptor substrate 1 and 2 sensitivity to insulin, while it increased glucose transporter 2 expression in the rat pancreas. The study findings imply that the hypoglycemic effect of the benzenesulfonamide derivative is due to enhancing liver sensitivity to regulate blood glucose level via the ACE2/Ang (1–7)/PI3K/AKT/mTOR pathway.
Mechanic-Driven Biodegradable Polyglycolic Acid/Silk Fibroin Nanofibrous Scaffolds Containing Deferoxamine Accelerate Diabetic Wound Healing
Authors: Zha Shenfang , Utomo Yohanes Kristo Sugiarto , Yang Li , Liang Guizhao , Liu Wanqian
Published: March 2022

The extracellular matrix (ECM), comprising of hundreds of proteins, mainly collagen, provides physical, mechanical support for various cells and guides cell behavior as an interactive scaffold. However, deposition of ECM, especially collagen content, is seriously impaired in diabetic wounds, which cause inferior mechanical properties of the wound and further delay chronic wound healing. Thus, it is critical to develop ECM/collagen alternatives to remodel the mechanical properties of diabetic wounds and thus accelerate diabetic wound healing. Here, we firstly prepared mechanic-driven biodegradable PGA/SF nanofibrous scaffolds containing DFO for diabetic wound healing. In our study, the results in vitro showed that the PGA/SF-DFO scaffolds had porous three-dimensional nanofibrous structures, excellent mechanical properties, biodegradability, and biocompatibility, which would provide beneficial microenvironments for cell adhesion, growth, and migration as an ECM/collagen alternative. Furthermore, the data in vivo showed PGA/SF-DFO scaffolds can adhere well to the wound and have excellent biodegradability, which is helpful to avoid secondary damage by omitting the removal process of scaffolds. The finite element analysis results showed that the application of silk fibroin-based scaffolds could significantly reduce the maximum stress around the wound. Besides, PGA/SF-DFO scaffolds induced collagen deposition, re-vascularization, recovered impaired mechanical properties up to about 70%, and ultimately accelerated diabetic wound healing within 14 days. Thus, our work provides a promising therapeutic strategy for clinically chronic wound healing.
Sustained Release of Co-Amorphous Matrine-Type Alkaloids and Resveratrol with Anti-COVID-19 Potential
Authors: Hu Dandan , Chen Xin , Li Duanxiu , Zhang Hailu , Duan Yanwen , Huang Yong
Published: March 2022

Matrine (MAR), oxymatrine (OMAR), and sophoridine (SPD) are natural alkaloids with varying biological activities; matrine was recently used for the treatment of coronavirus disease 2019 (COVID-19). However, the short half-lives and rapid elimination of these matrine-type alkaloids would lead to low oral bioavailability and serious side effects. Herein, resveratrol (RES) was selected as a co-former to prepare their co-amorphous systems to improve the therapeutic index. The formation of co-amorphous MAR-RES, OMAR-RES, and SPD-RES was established through powder X-ray diffraction and modulated temperature differential scanning calorimetry. Furthermore, Fourier transform infrared spectroscopy and NMR studies revealed the strong molecular interactions between resveratrol and these alkaloids, especially OMAR-RES. Matrine, oxymatrine, and sophoridine in the co-amorphous systems showed sustained release behaviors in the dissolution experiments, due to the recrystallization of resveratrol on the surface of co-amorphous drugs. The three co-amorphous systems exhibited excellent physicochemical stability under high relative humidity conditions. Our study not only showed that minor structural changes of active pharmaceutical ingredients may have distinct molecular interactions with the co-former, but also discovered a new type of sustained release mechanism for co-amorphous drugs. This promising co-amorphous drug approach may present a unique opportunity for repurposing these very promising drugs against COVID-19.
Prospective Application of Partially Digested Autologous Chondrocyte for Meniscus Tissue Engineering
Authors: Numpaisal Piya-on , Jiang Ching-Chuan , Hsieh Chang-Hsun , Chiang Hongsen , Chien Chung-Liang
Published: March 2022

Background: Meniscus tissue engineering has yet to achieve clinical application because it requires chondrogenic induction and in vitro cell expansion. Contrarily, cartilage engineering from autologous chondrocytes has been successfully applied in one-stage surgery. If the natural chondrogenic potential of meniscus cells can be demonstrated, meniscus tissue engineering would have more value in clinical settings. Materials and Methods: In total, 10 menisci and pieces of cartilage were obtained during total knee replacements. The tissues were collected for cell isolation and expansion. Their chondrogenic properties were examined by immunohistofluorescence and gene expression analyses. Results: In native cartilage, immunofluorescence demonstrated the presence of collagen I, aggrecan, and traces of collagen I, whereas comparable staining was seen in the inner and middle meniscus. The presence of collagen I but the absence of collagen II and aggrecan were observed in the outer meniscus. In passage 2, chondrocytes showed the presence of collagen II and aggrecan, and the absence of vimentin. The vimentin and aggrecan staining were comparable in the inner and middle meniscus cells, whereas the outer cells showed only vimentin staining. In the gene expression analyses, the expressions of collagen II and aggrecan in the native chondrocyte and the inner and middle meniscus were higher than those of the cells from the outer meniscus, but they were not different in collagen I. In the passage 2 culture, chondrocytes had a higher expression of collagen II and aggrecan than the meniscus cells. Cells from the inner and middle areas had higher collagen II and aggrecan expression than those from the outer meniscus. Conclusion: Without chondrogenic induction, inner and middle meniscus cells possess a chondrogenic phenotype. Specifically, native meniscus cells exhibited more robust chondrogenic potential compared with those of the passage 2 monolayer culture.
Synthesis and Properties of α-Mangostin and Vadimezan Conjugates with Glucoheptoamidated and Biotinylated 3rd Generation Poly(amidoamine) Dendrimer, and Conjugation Effect on Their Anticancer and Anti-Nematode Activities
Authors: Markowicz Joanna , Wołowiec Stanisław , Rode Wojciech , Uram Łukasz
Published: March 2022

α-Mangostin and vadimezan are widely studied potential anticancer agents. Their biological activities may be improved by covalent bonding by amide or ester bonds with the third generation poly(amidoamine) (PAMAM) dendrimer, substituted with α-D-glucoheptono-1,4-lactone and biotin. Thus, conjugates of either ester- (G3gh4B5V) or amide-linked (G32B12gh5V) vadimezan, and equivalents of α-mangostin (G3gh2B5M and G32B12gh5M, respectively), were synthesized, characterized and tested in vitro against cancer cells: U-118 MG glioma, SCC-15 squamous carcinoma, and BJ normal human fibroblasts growth, as well as against C. elegans development. α-Mangostin cytotoxicity, stronger than that of Vadimezan, was increased (by 2.5–9-fold) by conjugation with the PAMAM dendrimer (with the amide-linking being slightly more effective), and the strongest effect was observed with SCC-15 cells. Similar enhancement of toxicity resulting from the drug conjugation was observed with C. elegans. Vadimezan (up to 200 µM), as well as both its dendrimer conjugates, was not toxic against both the studied cells and nematodes. It showed an antiproliferative effect against cancer cells at concentrations ≥100 µM. This effect was significantly enhanced after conjugation of the drug with the dendrimer via the amide, but not the ester bond, with G32B12gh5V inhibiting the proliferation of SCC-15 and U-118 MG cells at concentrations ≥4 and ≥12 μM, respectively, without a visible effect in normal BJ cells. Thus, the drug delivery system based on the PAMAM G3 dendrimer containing amide bonds, partially-blocked amino groups on the surface, larger particle diameter and higher zeta potential can be a useful tool to improve the biological properties of transported drug molecules.
Withania somnifera: Progress towards a Pharmaceutical Agent for Immunomodulation and Cancer Therapeutics
Authors: Kashyap Vivek K. , Peasah-Darkwah Godwin , Dhasmana Anupam , Jaggi Meena , Yallapu Murali M. , Chauhan Subhash C.
Published: March 2022

Chemotherapy is one of the prime treatment options for cancer. However, the key issues with traditional chemotherapy are recurrence of cancer, development of resistance to chemotherapeutic agents, affordability, late-stage detection, serious health consequences, and inaccessibility. Hence, there is an urgent need to find innovative and cost-effective therapies that can target multiple gene products with minimal adverse reactions. Natural phytochemicals originating from plants constitute a significant proportion of the possible therapeutic agents. In this article, we reviewed the advances and the potential of Withania somnifera (WS) as an anticancer and immunomodulatory molecule. Several preclinical studies have shown the potential of WS to prevent or slow the progression of cancer originating from various organs such as the liver, cervix, breast, brain, colon, skin, lung, and prostate. WS extracts act via various pathways and provide optimum effectiveness against drug resistance in cancer. However, stability, bioavailability, and target specificity are major obstacles in combination therapy and have limited their application. The novel nanotechnology approaches enable solubility, stability, absorption, protection from premature degradation in the body, and increased circulation time and invariably results in a high differential uptake efficiency in the phytochemical’s target cells. The present review primarily emphasizes the insights of WS source, chemistry, and the molecular pathways involved in tumor regression, as well as developments achieved in the delivery of WS for cancer therapy using nanotechnology. This review substantiates WS as a potential immunomodulatory, anticancer, and chemopreventive agent and highlights its potential use in cancer treatment.
Challenges and Complications of Poly(lactic-co-glycolic acid)-Based Long-Acting Drug Product Development
Authors: Lim Yi Wen , Tan Wen Siang , Ho Kok Lian , Mariatulqabtiah Abdul Razak , Abu Kasim Noor Hayaty , Abd. Rahman Noorsaadah , Wong Tin Wui , Chee Chin Fei
Published: March 2022

Poly(lactic-co-glycolic acid) (PLGA) is one of the preferred polymeric inactive ingredients for long-acting parenteral drug products that are constituted of complex formulations. Despite over 30 years of use, there are still many challenges faced by researchers in formulation-related aspects pertaining to drug loading and release. Until now, PLGA-based complex generic drug products have not been successfully developed. The complexity in developing these generic drug products is not just due to their complex formulation, but also to the manufacturing process of the listed reference drugs that involve PLGA. The composition and product attributes of commercial PLGA formulations vary with the drugs and their intended applications. The lack of standard compendial methods for in vitro release studies hinders generic pharmaceutical companies in their efforts to develop PLGA-based complex generic drug products. In this review, we discuss the challenges faced in developing PLGA-based long-acting injectable/implantable (LAI) drug products; hurdles that are associated with drug loading and release that are dictated by the physicochemical properties of PLGA and product manufacturing processes. Approaches to overcome these challenges and hurdles are highlighted specifically with respect to drug encapsulation and release.
Evaluation of Current Community Pharmacist Practice in Saudi Arabia—A Cross-Sectional Study from Pharmacists’ Perspective (Part II)
Authors: Alhazmi Mohammad , Bajuayfir Abdulmajeed , Cheema Ejaz , Elrggal Mahmoud , Ali Majid
Published: March 2022

This study aimed to evaluate the current practice of community pharmacists from patients’ and pharmacists’ perspectives in Saudi Arabia. This paper presents the pharmacist’s perspective. A cross-sectional self-administered online survey was designed to collect responses from community pharmacists in Saudi Arabia from February to April 2021. The questionnaire consisted of several statements related to best practice in community pharmacy. Pharmacists’ responses to each statement were scored using a 5-point Likert scale. Higher scores represented a greater extent to which they adhered to best practice in the community pharmacy setting and vice versa. Data of 164 participants were included in the analysis. The minimum median score was related to the statement: Pharmacist explains the main side effects. The maximum median score was related to the statement: Pharmacist explains dosage regimen. Pharmacists aged 30 years or above and non-Saudi pharmacists had significantly higher median scores compared with pharmacists less than 30 years of age (p = 0.016) and Saudi pharmacists, respectively (p = 0.001). A gap between best practice and current practice of community pharmacists was observed. Policymakers can utilize these findings to provide targeted professional development opportunities for the practicing community pharmacists in order to improve the overall service and care for patients.
The Physiological Response of Different Brook Willow (Salix acmophylla Boiss.) Ecotypes to Salinity
Authors: Palm Emily , Klein Joshua D. , Mancuso Stefano , Guidi Nissim Werther
Published: March 2022

Few phytoremediation studies have been conducted under semi-arid conditions where plants are subjected to drought and/or salinity stress. Although the genus Salix is frequently used in phytoremediation, information regarding its tolerance of drought and salinity is limited. In the present study, Salix acmophylla Boiss. cuttings from three sites (Adom, Darom and Mea She’arim) were tested for tolerance to salinity stress by growing them hydroponically under either control or increasing NaCl concentrations corresponding to electrical conductivities of 3 and 6 dS m−1 in a 42-day greenhouse trial. Gas exchange parameters, chlorophyll fluorescence and concentration, and water-use efficiency were measured weekly and biomass was collected at the end of the trial. Root, leaf and stem productivity was significantly reduced in the Adom ecotype, suggesting that Darom and Mea She’arim are the more salt-tolerant of the three ecotypes. Net assimilation and stomatal conductance rates in salt-treated Adom were significantly reduced by the last week of the trial, coinciding with reduced intrinsic water use efficiency and chlorophyll a content and greater stomatal aperture. In contrast, early reductions in stomatal conductance and stomatal aperture in Darom and Mea She’arim stabilized, together with pigment concentrations, especially carotenoids. These results suggest that Darom and Mea She’arim are more tolerant to salt than Adom, and provide further phenotypic support to the recently published data demonstrating their genetic similarities and their usefulness in phytoremediation under saline conditions.
Elderberries—A Source of Bioactive Compounds with Antiviral Action
Authors: Mocanu Mirela Lăcrămioara , Amariei Sonia
Published: March 2022

In the current context, when more and more unknown pathogens appear, healthy eating and supplementing it with natural products play an increasingly important role in maintaining the health of the body. The European black elder (Sambucus nigra), found in abundance in the spontaneous flora, can provide us, as a raw material, elderberries, which have been known for thousands of years as having nutritional and healing properties. The phytotherapeutic principles found in elderberry fruits give them antiviral, antibacterial and antidiabetic properties, antitumor potential, antioxidant, antidepressant and immune boosting properties, as well as a certain impacts on obesity and metabolic dysfunctions. Polyphenols and lectins give elderberry fruits the ability to inhibit coronaviruses, which is a topic of great interest in our times. This article summarizes the existing data regarding the chemical composition, active principles and biopharmaceutical properties of elderberries, as well as their use.
5-Aminolevulinic Acid and 24-Epibrassinolide Improve the Drought Stress Resilience and Productivity of Banana Plants
Authors: Helaly Mohamed N. , El-Hoseiny Hanan M. , Elsheery Nabil I. , Kalaji Hazem M. , de los Santos-Villalobos Sergio , Wróbel Jacek , Hassan Islam F. , Gaballah Maybelle S. , Abdelrhman Lamyaa A. , Mira Amany M. , Alam-Eldein Shamel M.
Published: March 2022

Plant growth, development, and productivity are adversely affected under drought conditions. Previous findings indicated that 5-aminolevulinic acid (ALA) and 24-epibrassinolide (EBL) play an important role in the plant response to adverse environmental conditions. This study demonstrated the role of ALA and EBL on oxidative stress and photosynthetic capacity of drought-stressed ‘Williams’ banana grown under the Egyptian semi-arid conditions. Exogenous application of either ALA or EBL at concentrations of 15, 30, and 45 mg·L−1 significantly restored plant photosynthetic activity and increased productivity under reduced irrigation; this was equivalent to 75% of the plant’s total water requirements. Both compounds significantly reduced drought-induced oxidative damages by increasing antioxidant enzyme activities (superoxide dismutase ‘SOD’, catalase ‘CAT’, and peroxidase ‘POD’) and preserving chloroplast structure. Lipid peroxidation, electrolyte loss and free non-radical H2O2 formation in the chloroplast were noticeably reduced compared to the control, but chlorophyll content and photosynthetic oxygen evolution were increased. Nutrient uptake, auxin and cytokinin levels were also improved with the reduced abscisic acid levels. The results indicated that ALA and EBL could reduce the accumulation of reactive oxygen species and maintain the stability of the chloroplast membrane structure under drought stress. This study suggests that the use of ALA or EBL at 30 mg·L−1 can promote the growth, productivity and fruit quality of drought-stressed banana plants.
Patterns of Traditional and Modern Uses of Wild Edible Native Plants of Chile: Challenges and Future Perspectives
Authors: León-Lobos Pedro , Díaz-Forestier Javiera , Díaz Rodrigo , Celis-Diez Juan L. , Diazgranados Mauricio , Ulian Tiziana
Published: March 2022

Wild Edible Plants (WEPs) still play a vital role in the subsistence of many traditional communities, while they are receiving increasing recognition in tackling food security and nutrition at the international level. This paper reviews the use patterns of native WEPs in Chile and discusses their role as future crops and sources of food products. We conducted an extensive literature review by assessing their taxonomic diversity, life forms, consumption and preparation methods, types of use (traditional and modern), and nutritional properties. We found that 330 native species were documented as food plants, which represent 7.8% of the total flora of Chile. These species belong to 196 genera and 84 families. The most diverse families are Asteraceae (34), Cactaceae (21), Fabaceae (21), Solanaceae (20) and Apiaceae (19), and the richest genera in terms of number of species are Solanum (9), Ribes (8), Berberis (7), Hypochaeris (7) and Oxalis (6). Perennial herbs are the predominant life form (40%), followed by shrubs (35%), trees (14%), and annual and biannual herbs (11%). Fruits (35.8%), roots (21.5%) and leaves (20.0%) are the parts of plants consumed the most. Nine different food preparation categories were identified, with ‘raw’ forming the largest group (43%), followed by ‘beverages’ (27%), ‘savoury preparations’ (27%), and ‘sweet’ (13%). Almost all native Chilean WEPs have reported traditional food uses, while only a few of them have contemporary uses, with food products mainly sold in local and specialised markets. Species’ richness, taxonomic diversity and family representation have similar patterns to those observed for the world flora and other countries where surveys have been carried out. Some Chilean native WEPs have the potential to become new crops and important sources of nutritious and healthy products in the food industry. However, there are still many gaps in knowledge about their nutritional, anti-nutritional and biochemical characteristics; future research is recommended to unveil their properties and potential uses in agriculture and the food industry.
Synthesis and Characterization of Natural Polymeric Membranes Composed of Chitosan, Green Banana Peel Extract and Andiroba Oil
Authors: Ferreira Elisângela da Silva , Paranhos Sheila Barbosa , da Paz Simone Patrícia Aranha , Canelas Caio Augusto de Almeida , Nascimento Luís Adriano Santos do , Passos Marcele Fonseca , da Silva Alisson Clay Rios , Monteiro Sergio Neves , Paula Marcos Vinícius da Silva , Candido Verônica Scarpini
Published: March 2022

Chitosan comprises polymeric macromolecules with technical and biological properties that have been used in biomedical healing applications requiring anti-microbial and anti-inflammatory capacities worldwide. In the tropical regions, green banana peel extract and andiroba oil are considered natural products with wound healing properties. The present study, for the first time, synthesized chitosan/green banana peel extract/andiroba oil (CGA) membranes and analyzed them using scanning electron microscopy (SEM) and the swelling and moisture tests. The CGA membranes together with control membranes of plain chitosan and chitosan plus green banana peel extract, were characterized by contact angle measurement, X-ray diffraction (XRD) and differential scanning calorimetry (DSC). Macroscopic analysis showed significant differences in color and transparency caused by the number of decoction days used for extract preparation and the oil content. SEM observations disclosed the formation of two phases, lipid and polymer, in the CGA. The number of decoction days and the andiroba oil content were inversely related to the swelling moisture uptake. All membranes were found to be hydrophilic with contact angles less than 90°. The incorporation of plant extract and oil promoted the appearance of related XRD peaks. DSC curves revealed a reduction in the enthalpy of the CGA membranes compared with plain chitosan, which might be attributed to the evaporation of the natural extract and oil. Based on these findings, the studied newly synthesized membranes demonstrated a potential for healing epithelial lesions.
Rheological Investigation of Hydroxypropyl Cellulose–Based Filaments for Material Extrusion 3D Printing
Authors: Than Yee Mon , Suriyarak Sarisa , Titapiwatanakun Varin
Published: March 2022

The rheological properties of drug–polymer mixtures have a significant influence on their processability when using transformative techniques, such as hot-melt-extrusion and material-extrusion 3D printing; however, there has been limited data on printable systems. This study investigated the rheological properties of 17 formulations of successful printed tablets for both immediate and controlled release. Hydroxypropyl cellulose was used in various ratios to obtain printable filaments in combination with various drugs (indomethacin or theophylline), polymers and disintegrants. The complex viscosity, shear thinning behavior and viscoelastic properties were affected by the drug load, polymer composite, disintegrant type, temperature and shear rate applied. Larger windows of processing viscosity were revealed. The viscosity of the printable blends could be as low as the range 10–1000 Pa·s at 100 rad/s angular frequency. All formulations showed shear thinning behavior with a broad slope of complex viscosity from −0.28 to −0.74. The addition of 30–60% drug or disintegrant tended to have greater viscosity values. While microcrystalline cellulose was found to be an alternative additive to lower the storage and loss modulus among disintegrants. This rheological data could be useful for the preformulation and further development of material-extrusion 3D-printing medicines.
Optimization Design and Performance Evaluation of a Hybrid Excitation Claw Pole Machine
Authors: Cao Yu , Zhu Shushu , Yu Junyue , Liu Chuang
Published: March 2022

Claw pole machines (CPMs) have the advantages of a simple structure and low cost; therefore, they are commonly used in electric vehicles (EV). However, the methods to improve reliability and efficiency should be studied. So, a new type of hybrid excitation claw pole machine (HE-CPM) for EV is proposed. The permanent magnet (PM) is inserted in the rotor, and the field winding is placed on the front and back ending cover. Because the hybrid flux path of the proposed machine is three-dimensional (3D) and 3D finite element analysis (FEA) is time-consuming, a 3D magnet equivalent circuit (MEC) method considering rotor position is proposed and results between 3D MEC and FEA are compared. Particle swarm optimization (PSO) and 3D MEC are combined in the optimization design of HE-CPM. The optimized results prove the effectiveness of the optimization method. Finally, the flux density distribution, electromagnetic characteristics of HE-CPM are evaluated. The thermal analysis and mechanical stress analysis are carried out. The HE-CPM prototype was manufactured. The direct current (DC) bus voltages under different excitation currents and load currents are measured and compared with those of FEA. When the armature current and the excitation current are 7 A and 4 A, respectively, the rated power and rated speed of HE-CPM are 10.28 kW and 3000 rpm, respectively. The maximum efficiency is 89%. FEA results are basically consistent with the experimental results. Accurate results and time savings can be achieved by combining PSO and 3D MEC.
Liturgy and Learning: The Encyclopaedic Function of the Old English Martyrology
Authors: Gallagher John Joseph
Published: March 2022

This article examines the broad, encyclopaedic ambit of the scholarly information contained in the ninth-century Old English Martyrology. Martyrologies generally serve as para-liturgical resources outlining the contours of the liturgical year and the biographies of the saints commemorated throughout its course. However, the Old English Martyrology, the earliest European example of a vernacular, prose martyrology, adapts the genre into a more multivalent, scholarly handbook that instructs and informs its users—generally, practitioners of the liturgy—in a variety of topics. Subjects covered in the text include geography, language, hagiography, temporal reckoning, computus, astronomy, cosmology, meteorology, science, liturgy, and learning of a general Christian nature pertaining to the saints and the liturgical year. The present volume considers the impact of liturgy upon various facets of medieval intellectual, cultural, religious, political, and social life. The article at hand considers how the liturgical year is used as the framework around which instruction, edification, and general ecclesiastical learning might be imparted. While liturgical texts generally constitute formulae to be enacted by practitioners, para-liturgical resources provide background information that is germane to the liturgy, the liturgical year, and ecclesiastical life. This article begins with an examination of the development of the kalendar of the saints and the genre and form of the martyrology. It moves on to examine the different types of scholarly learning contained in the Old English Martyrology, the purpose of such details for the professional religious user, and what this information tells us about the text’s application. Overall, this article considers the Old English Martyrology as an interdisciplinary manual dealing with liturgy, the liturgical cycle of the saints, and the subjects it impinges upon.
The Daily Spiritual Experience Scale: Empirical Relationships to Resiliency-Related Outcomes, Addictions, and Interventions
Authors: Underwood Lynn G. , Vagnini Kaitlyn M.
Published: March 2022

The Daily Spiritual Experience Scale (DSES) is a 16-item self-report measure designed to assess a set of experiences that may occur in the context of daily life for many different kinds of people. These include awe, a merciful attitude, giving other-centered love, deep inner peace, finding strength, guidance, or consolation from a transcendent source, among others. The DSES includes theistic and non-theistic language and alternatives, and has proven useful for those from many religions and for the unaffiliated. Since its original publication, it has been translated into over 40 languages, used in hundreds of published studies, and adopted for use in many practical settings. Empirically, the DSES predicts greater resilience, stress buffering, post-traumatic growth, and a sense of meaning in the face of illness, trauma, and daily stressors, as well as less substance abuse and burnout. Intervention studies using the DSES show that a variety of interventions can increase the frequency of these experiences. In this article, we will provide a brief overview of the scale and review its use in the empirical literature with respect to resilience and related outcomes. Findings suggest that the experiences measured by the DSES may serve as a resource for those experiencing distress of various kinds.
The Application of the Soft Modeling Method to Evaluate Changes in Customer Behavior towards e-Commerce in the Time of the Global COVID-19 Pandemic
Authors: Dewalska-Opitek Anna , Bilińska Katarzyna , Cierpiał-Wolan Marek
Published: March 2022

As a result of the COVID-19 pandemic, business and consumer behavior towards online consumption and digital payments has changed. This trend, although significant, may be observed, to a varying extent, among customers across the European Union. This study aims to investigate if, and to what extent, the COVID-19 pandemic has had a powerful impact on online consumer behavior in EU (European Union) countries. The empirical research using a soft modeling method supplements theoretical deliberations based on critical literature review. A conceptual model was adopted. Three first-order latent variables were selected for the analysis: “online customer behavior”, “online activity” and “willingness to spend online”, to which all analyzed indicators (14) were classified. The analysis of the loadings of latent variables for 2019 and 2020 allowed the impact of the pandemic on customer behavior to be observed, although this was not the same across all EU countries. Clustering performed with the hit map enabled the identification of four groups of countries. Significant changes in behavior were observed in countries such as Poland, Ireland, Romania, Hungary, Slovenia, Spain, and Finland. The results of the classification based on the values of three latent variables indicate that only the composition of one group (Bulgaria and Romania) remained unchanged during the study period. Research discussion was presented, and further fields of study were identified.
Assessment of Canopy Health with Drone-Based Orthoimagery in a Southern Appalachian Red Spruce Forest
Authors: Harris Ryley C. , Kennedy Lisa M. , Pingel Thomas J. , Thomas Valerie A.
Published: March 2022

Consumer-grade drone-produced digital orthoimagery is a valuable tool for conservation management and enables the low-cost monitoring of remote ecosystems. This study demonstrates the applicability of RGB orthoimagery for the assessment of forest health at the scale of individual trees in a 46-hectare plot of rare southern Appalachian red spruce forest on Whitetop Mountain, Virginia. We used photogrammetric Structure from Motion software Pix4Dmapper with drone-collected imagery to generate a mosaic for point cloud reconstruction and orthoimagery of the plot. Using 3-band RBG digital orthoimagery, we visually classified 9402 red spruce individuals, finding 8700 healthy (92.5%), 251 declining/dying (2.6%), and 451 dead (4.8%). We mapped individual spruce trees in each class and produced kernel density maps of health classes (live, dead, and dying). Our approach provided a nearly gap-free assessment of the red spruce canopy in our study site, versus a much more time-intensive field survey. Our maps provided useful information on stand mortality patterns and canopy gaps that could be used by managers to identify optimal locations for selective thinning to facilitate understory sapling regeneration. This approach, dependent mainly on an off-the-shelf drone system and visual interpretation of orthoimagery, could be applied by land managers to measure forest health in other spruce, or possibly spruce-fir, communities in the Appalachians. Our study highlights the usefulness of drone-produced orthoimagery for conservation monitoring, presenting a valid and accessible protocol for the monitoring and assessment of forest health in remote spruce, and possibly other conifer, populations. Adoption of drone-based monitoring may be especially useful in light of climate change and the possible displacement of southern Appalachian red spruce (and spruce-fir) ecosystems by the upslope migration of deciduous trees.
Hyperspectral Anomaly Detection Based on Improved RPCA with Non-Convex Regularization
Authors: Yao Wei , Li Lu , Ni Hongyu , Li Wei , Tao Ran
Published: March 2022

The low-rank and sparse decomposition model has been favored by the majority of hyperspectral image anomaly detection personnel, especially the robust principal component analysis(RPCA) model, over recent years. However, in the RPCA model, ℓ0 operator minimization is an NP-hard problem, which is applicable in both low-rank and sparse items. A general approach is to relax the ℓ0 operator to ℓ1-norm in the traditional RPCA model, so as to approximately transform it to the convex optimization field. However, the solution obtained by convex optimization approximation often brings the problem of excessive punishment and inaccuracy. On this basis, we propose a non-convex regularized approximation model based on low-rank and sparse matrix decomposition (LRSNCR), which is closer to the original problem than RPCA. The WNNM and Capped ℓ2,1-norm are used to replace the low-rank item and sparse item of the matrix, respectively. Based on the proposed model, an effective optimization algorithm is then given. Finally, the experimental results on four real hyperspectral image datasets show that the proposed LRSNCR has better detection performance.
Ka-Band Doppler Scatterometry: A Strong Wind Case Study
Authors: Yurovsky Yury Yu. , Kudryavtsev Vladimir N. , Grodsky Semyon A. , Chapron Bertrand
Published: March 2022

Global joint measurements of sea surface winds and currents are planned using satellite-based Doppler scatterometers operating in the Ka-band to achieve improved spatial resolution and retrieval accuracy. Still, the knowledge of sea surface Ka-band backscatter properties is poor, particularly, at high winds (>20 m s−1). Sea surface radar cross-section in the Ka-band, in contrast to that in the lower frequency Ku-/X-/C-/L-bands, is likely more sensitive to sea spray, small-scale particles typically present at high winds. In this paper, tower-based field data collected by a continuous dual-co-polarized Ka-band radar during a strong offshore wind event (with wind speed reaching 33 m s−1) are analyzed. This katabatic wind event (≈12 h long) was also recorded by supplementary wave, wind, and current sensors. At the wave fetch of ≈1 km, the maximum wavelength of observed offshore waves was ≈10 m. For such extremely young wind–sea conditions, an apparent sea spray generation was observed during wind gusts. Radar measurements were performed at 20∘ and 45∘ incidence angles, mostly for cross- and up-wind azimuth look geometry. Based on these high wind measurements, the previously developed Ka-band empirical model is tested and compared with other published geophysical model functions. Dual-co-polarized measurements are used to infer resonant Bragg and non-Bragg scattering components and assess the short wind wave spectrum, which shows a clear tendency for saturation at high winds. The presence of sea spray signatures is apparent in the high-frequency tails of radar Doppler spectra, but their overall contribution to the Doppler centroid frequency is weak. Hence, the standard modulation transfer function approach developed for moderate winds is still applicable at high winds for interpreting the wave-induced Doppler velocity and inferring sea surface currents. These results can also be useful for understanding Doppler scatterometry measurements in tropical cyclones.
Experimental Results of Three-Dimensional Modeling and Mapping with Airborne Ka-Band Fixed-Baseline InSAR in Typical Topographies of China
Authors: Gao Jian , Sun Zhongchang , Guo Huadong , Wei Lideng , Li Yongjie , Xing Qiang
Published: March 2022

Interferometric synthetic aperture radar (InSAR) has become a key technology for producing high-precision digital surface models (DSMs) and digital orthophoto maps (DOMs) in full time and all weathers. Airborne millimeter-wave InSAR, with large-scale and high-resolution imaging, is characterized by high spatial resolution, flexibility, and immunity to loss-of-correlation. This paper introduces our modeling experiments with airborne dual-antenna, Ka-band InSAR regarding typical topographies of China. Ka-band SAR data were acquired in designated experimental areas in flat (Heyang area in Shaanxi) and mountainous areas (Shibing area in Guizhou and Qionglai area in Sichuan). The key processing of the experimental data for DSMs and DOMs is demonstrated in the paper, especially the proposed robust and efficient phase unwrapping (PU) method for the interferometric data and block adjustment method of strip calibration. The results show that the proposed unwrapping method can provide reliable unwrapped phase results in undulating areas, and the block adjustment can carry out consistent calibration for strips with sparse ground control points (GCPs). The accuracy assessment of the DSM shows that the coordinate root mean square error (RSME) of the obtained DSM is less than 2 m in height, and 2.5 m horizontally, which meets the 1:5000 requirement for topographic mapping in difficult areas.
24 km High-Performance Raman Distributed Temperature Sensing Using Low Water Peak Fiber and Optimized Denoising Neural Network
Authors: Wu Hao , Du Haoze , Zhao Can , Tang Ming
Published: March 2022

Raman distributed optical fiber temperature sensing (RDTS) has been extensively studied for decades because it enables accurate temperature measurements over long distances. The signal-to-noise ratio (SNR) is the main factor limiting the sensing distance and temperature accuracy of RDTS. We manufacture a low water peak optical fiber (LWPF) with low transmission loss to improve the SNR for long-distance application. Additionally, an optimized denoising neural network algorithm is developed to reduce noise and improve temperature accuracy. Finally, a maximum temperature uncertainty of 1.77 °C is achieved over a 24 km LWPF with a 1 m spatial resolution and a 1 s averaging time.