bluuebunny/crossref_metadata_2025 huggingface dataset:
Multimodal imaging for tumour characterization from micro‐ to macroscopic level using a newly developed dorsal chamber designed for long‐term follow‐up
Authors: Rouffiac Valérie , Ser‐Le Roux Karine , Salomé‐Desnoulez Sophie , Leguerney Ingrid , Ginefri Jean‐Christophe , Sébrié Catherine , Jourdain Laurène , Lécluse Yann , Laplace‐Builhé Corinne
Published: October 2019

Optical imaging of living animals is a unique method of studying the dynamics of physiological and pathological processes at a subcellular level. One‐shot acquisitions at high resolution can be achieved on exteriorized organs before animal euthanasia. For longitudinal follow‐up, intravital imaging can be used and involves imaging windows implanted in cranial, thoracic or dorsal regions. Several imaging window models exist, but none have proven to be applicable for long‐term monitoring and most biological processes take place over several weeks. Moreover, none are compatible with multiple imaging modalities, meaning that different biological parameters cannot be assessed in an individual animal. We developed a new dorsal chamber that was well tolerated by mice (over several months) and allowed individual and collective cell tracking and behaviour analysis by optical imaging, ultrasound and magnetic resonance tomography. This new model broadens potential applications to areas requiring study of long‐term biological processes, as in cancer research.
ADC on Diffusion Imaging: The MR Analog of SUV on FDG‐PET: Perfect Is the Enemy of Good
Authors: Anzai Yoshimi
Published: October 2019

Level of Evidence: 5

Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:286–287.
Heat‐induced amyloid‐like aggregation of β‐lactoglobulin affected by glycation by α‐dicarbonyl compounds in a model study
Authors: Zhao Di , Zhang Xia , Xu Dan , Su Guoying , Li Bing , Li Chunbao
Published: October 2019

BACKGROUND

α‐Dicarbonyl compounds are widely generated in the Maillard reaction, caramelization and oil oxidation during heat treatment. These compounds can readily react with lysine and arginine residues of a protein, whereas the influence of these compounds on protein structure and quality has seldom been revealed. This study compared influence of glycation by glucose and α‐dicarbonyl compounds on amyloid‐like aggregation of β‐lactoglobulin (β‐LG), both fibrillation kinetics and conformation of aggregates were studied.

RESULTS

Compared with glycation by glucose, the glycation by α‐dicarbonyl compounds resulted in faster reduction of free amino group, sulfydryl group, and the relative content of β‐sheet secondary structure, according to the ultraviolet (UV) spectra or circular dichroism (CD) spectra results. Based on the analysis of fibrillation kinetics using thioflavin T (ThT) binding assay, the glycation by α‐dicarbonyls were more efficient in suppressing the growth of fibrillar aggregates. In addition, glycation by α‐dicarbonyl resulted in amorphous oligomers, which were compared with the amyloid‐like aggregates in control and glucose‐glycated samples, based on the transmission electron microscopy (TEM) observation.

CONCLUSIONS

Glycation by α‐dicarbonyl compounds induced larger decline in the β‐sheet structure of β‐LG than glycation by glucose, and thus largely suppressed the amyloid‐like aggregation of β‐LG and changed the morphology of aggregates. © 2019 Society of Chemical Industry
Novel adsorptive materials by adenosine 5ʹ‐triphosphate imprinted‐polymer over the surface of polystyrene nanospheres for selective separation of adenosine 5ʹ‐triphosphate biomarker from urine
Authors: Jadda Ramana , Madhumanchi Sreenu , Suedee Roongnapa
Published: October 2019

In this study, we have developed a method to assess adenosine 5ʹ‐triphosphate by adsorptive extraction using surface adenosine 5′‐triphosphate‐imprinted polymer over polystyrene nanoparticles (412 ± 16 nm) for selective recognition/separation from urine. Molecularly imprinted polymer was synthesized by emulsion copolymerization reaction using adenosine 5′‐triphosphate as a template, functional monomers (methacrylic acid, N‐isopropyl acrylamide, and dimethylamino ethylmethacrylate) and a crosslinker, methylenebisacrylamide. The binding capacities of imprinted and non‐imprinted polymers were measured using high‐performance liquid chromatography with UV detection with a detection limit of 1.6 ± 0.02 µM of adenosine 5′‐triphosphate in the urine. High binding affinity (QMIP, 42.65 µmol/g), and high selectivity and specificity to adenosine 5′‐triphosphate compared to other competitive nucleotides including adenosine 5ʹ‐diphosphate, adenosine 5ʹ‐monophosphate, and analogs such as adenosine, adenine, uridine, uric acid, and creatinine were observed. The imprinting efficiency of imprinted polymer is 2.11 for urine (QMIP, 100.3 µmol/g) and 2.51 for synthetic urine (QMIP, 48.5 µmol/g). The extraction protocol was successfully applied to the direct extraction of adenosine 5′‐triphosphate from spiked human urine indicating that this synthesized molecularly imprinted polymer allowed adenosine 5′‐triphosphate to be preconcentrated while simultaneously interfering compounds were removed from the matrix. These submicron imprinted polymers over nano polystyrene spheres have a potential in the pharmaceutical industries and clinical analysis applications.
A nona‐band narrow‐frame antenna with a defected ground structure for mobile phone applications
Authors: Pang Jiarui , Zhu Mingmin , Yu Guoliang , Zhou Haomiao
Published: October 2019

A nona‐band narrow‐frame antenna with a defected ground structure for mobile phone applications is presented in this article. From the analysis of the structure, the coupled‐fed antenna mainly consists of four parts: bending feeding strip, coupling shorted strip, copper plate and defected ground structure. It can effectively cover LTE700/GSM850/GSM900/DCS1800/PCS1900/UMTS2100/LTE2300/LTE2500 and the ninth band on 3300‐4200 MHz (including LTE3500), which may be applied to the future 5G. The size of the nona‐band antenna is 80 × 7.5 × 5 mm3, and the defected ground structure is only 55 × 0.5 mm2. This structure effectively widens the bandwidth of the low‐frequency band and realizes 2G/3G/4G and possible coverage of the 5G operating band without loading the lumped elements. Thus, it is suitable for smartphone application. A prototype of the proposed antenna is manufactured and measured. The measured −6 dB impedance band‐widths in the low, mid and high bands are 340 MHz (630‐970 MHz), 1410 MHz (1510‐2920 MHz) and 1060 MHz (3160‐4220 MHz), respectively. In addition, the efficiency of the antenna is greater than 60% in most of the working frequency bands, and the antenna has good radiation performances.
Assessment of digital predistortion methods for DFB‐SSMF radio‐over‐fiber links linearization
Authors: Hadi Muhammad Usman , Kantana Chouaib , Traverso Pier A. , Tartarini Giovanni , Venard Olivier , Baudoin Geneviève , Polleux Jean‐Luc
Published: October 2019

This letter presents a comparative evaluation between three different behavioral models to perform digital predistortion (DPD) that enhances the linearity of radio‐over‐fiber (RoF)‐based front haul links for the mobile network. In particular, the intention is to jump out of the volterra box and propose models based on segmentation approach. Especially the decomposed vector rotation (DVR) model is compared to volterra polynomials such as memory and generalized memory polynomial (GMP) architectures. DPD is employed to RoF links that are based on distributed feedback laser emitting at 1310 nm, and standard single‐mode fiber for long‐term evolution 20‐MHz signal with 256‐QAM modulation format. The effectiveness of the digital predistortion methodology is investigated for varying input powers in terms of normalized mean square error, adjacent channel power ratio, and error vector magnitude. The experimental results demonstrate that DVR achieves elevated linearization when compared to memory polynomial and GMP models.
Focus on Dead‐End Mains to Improve Water Quality
Authors: Klidies Jennifer , Ybanez Crystal
Published: October 2019

Eliminating dead‐end mains is a huge undertaking for water utilities. But the city of Corpus Christi, Texas, simplifies the process with easily accessible tools and collaboration among its mapping, water quality, and line maintenance staff.
Utility Operations Reduce Water Loss, Improve Security, and Enhance Resilience
Authors: Mix Nelson , Lai Alan , Thompson Kenneth , Seachrist Steven C.
Published: October 2019

The Gwinnett County Department of Water Resources (Ga.) conducted a demonstration project with the aim of integrating innovative technologies with internal practices to detect and reduce water loss.
Numerical investigation of the resonance behavior of flow‐excited Helmholtz resonators
Authors: Weitz Michael , Schoder Stefan , Kaltenbacher Manfred
Published: October 2019

Functional gaps of cars combined with the underlying volume of air represent Helmholtz resonators that are excited at the Helmholtz frequency by the turbulent flow. Based on a model that describes the spatial coherence of pressure fluctuations beneath a turbulent boundary layer, we present how to compute an extensive synthetic excitation signal without performing computational fluid dynamics (CFD) computations. Moreover, this contribution shows the capabilities of complex fluid models to better predict the resonance behavior of Helmholtz resonators.
The nonrelativistic limit of Dirac operators with Lorentz scalar δ‐shell interactions
Authors: Holzmann Markus
Published: October 2019

In this note it is shown that the nonrelativistic limit of the Dirac operator with a Lorentz scalar δ‐shell interaction of constant strength supported on a C2‐smooth surface in ℝ3 is the Schrödinger operator with a δ‐potential of the same strength.
Numerical investigation of wear processes by a gradient‐enhanced damage‐plasticity model
Authors: Hoormazdi Golnaz , Hackl Klaus , Junker Philipp
Published: October 2019

The prediction of failure mechanism in structures are always an important topic in the field of computational mechanics. Finite element computations of an inelastic material involving softening behavior (e.g. softening plasticity or damage) can suffer from strongly mesh‐dependent results. Therefore, such continuum models should be equipped with a regularization (localization limiter) strategy to overcome the above‐mentioned problem.

In this study, we present a framework for gradient‐enhancement for coupled damage‐plasticity material model derived by means of Hamilton's principle for non‐conservative continua. This model is applied for the numerical investigation of wear processes as they occur, e.g. in the case of mechanized tunneling. These investigations require a fine resolution of the involved constituents (cut sheet and abrasive particles in the soil). Consequently, a numerical strategy for the damage‐plasticity model is demanded that allows for time‐efficient simulations.

In this paper, we present a first step to the mentioned ultimate goal. To this end, a numerical framework for gradient‐enhanced damage‐plasticity coupling is proposed that is based on a combination of the finite element method with strategies from meshless methods. We demonstrate that this framework keeps the computational effort limited and for each load step close to the purely elastic problems. Several numerical examples prove the elimination of the pathological mesh dependency of the results. Furthermore, first results to the simulation of wear in tunneling machines are presented.
Convective dissolution in porous media: experimental investigation in Hele‐Shaw cell
Authors: Alipour Mobin , De Paoli Marco
Published: October 2019

The process of solutal convection in porous media is here studied experimentally in a Hele‐Shaw cell. Motivated by the carbon sequestration process, potassium permanganate and water are used to mimic the dissolution of carbon dioxide in brine in underground geological formations. An optical method is used to accurately reconstruct the solute concentration. In this work, we examine the influence of different calibration conditions on the measurement of the solute dissolution rate and we provide indications to improve the accuracy of the technique.
A model‐based strategy for safety assessment of a robot arm interacting with humans
Authors: Kovincic Nemanja , Gattringer Hubert , Müller Andreas , Weyrer Matthias , Schlotzhauer Andreas , Kaiser Lukas , Brandstötter Mathias
Published: October 2019

Impact and the resulting contact forces can be determined by dynamic simulation once a validated model for the robot and of the contact area of the human is available. Methods for the identification of relevant geometric and dynamic parameters of the robot model are well established. While the experimental validation of constitutive models for human body contact is still topic of ongoing research, which gave rise to the ISO/TS 15066 guidelines, adequate models are already available for computational simulation of human‐robot contact scenarios. However, dynamical simulations cannot be applied to exhaustively explore and assess all possible contact scenarios with the robot workspace. In this paper, first the model used for impact simulation is described and simulation as well experimental results are reported for contact at a predefined location. Then, the ability of the presented model to predict the measured contact force is discussed.
Coordination Bonds and Diels–Alder Bonds Dual Crosslinked Polymer Networks of Self‐healing Polyurethane
Authors: Lin Changhong , Sheng Dekun , Liu Xiangdong , Xu Shaobin , Ji Fance , Dong Li , Zhou Yan , Yang Yuming
Published: October 2019

A dual crosslinked self‐healing polyurethane was prepared with robust mechanical properties through the dynamic reversible pyridine‐Fe3+ coordination bonds and Diels–Alder (DA) covalent bonds dual crosslinking strategy. Moreover, the mechanical properties and self‐healing ability of polyurethane can be tuned readily by different ratio of the coordination bonds and DA bonds. Under external load, the coordination bonds serve as sacrificial bonds are broken to dissipate energy, the DA bonds can keep the shape of sample. With the coordination bonds participation, the damaged samples can be healed under moderate heating treatment or with the aid of FeCl3 solution. © 2019 Wiley Periodicals, Inc. J. Polym. Sci., Part A: Polym. Chem. 2019, 57, 2228–2234
Comparing in vivo and ex vivo fiberoptic diffuse reflectance spectroscopy in colorectal cancer
Authors: Baltussen Elisabeth J.M. , Brouwer De Koning Susan G. , Hendriks Benno H.W. , Jóźwiak Katarzyna , Sterenborg Henricus J.C.M. , Ruers Theo J.M.
Published: October 2019

In vivo data acquisition using fiberoptic diffuse reflectance spectroscopy (DRS) is more complicated and less controlled compared to ex vivo data acquisition. It would be of great benefit if classifiers for in vivo tissue discrimination based on DRS could be trained on data obtained ex vivo. In this study, in vivo and ex vivo DRS measurements are obtained during colorectal cancer surgery. A mixed model statistical analysis is used to examine the differences between the two datasets. Furthermore, classifiers are trained and tested using in vivo and ex vivo data. It is found that with a classifier trained on ex vivo data and tested on in vivo data, similar results are obtained compared to a classifier trained and tested on in vivo data. In conclusion, under the conditions used in this study, classifiers intended for in vivo tissue discrimination can be trained on ex vivo data.
Engaging Practitioners as Inquirers: Co-constructing Visions for Music Teacher Education in Nepal
Authors: Treacy Danielle Shannon
Published: October 2019

This chapter explores how co-constructing visions might engage teachers as inquirers in a ‘majority world’ context by reflecting on a series of 16 Appreciative Inquiry workshops involving over 50 musician-teachers in the Kathmandu Valley, Nepal in 2016. It extends the concept of teachers’ visions (Hammerness, Teach Educ Q 31(Fall):33–43, 2004) through socio-cultural anthropologist Arjun Appadurai’s notions of the imagination (Modernity at large: Cultural dimensions of globalization. University of Minnesota Press, Minneapolis, 1996) and the social and cultural capacity to aspire (Culture and public action. Stanford University Press, Stanford, 2004). The chapter reflects on the processes that took place when co-constructing visions, including the ways co-constructing visions may have been the fuel for action, and analyzes the implications of the resulting co-constructed visions. The findings highlight the importance of developing and supporting collaborative learning for the development of both preservice and inservice music teacher education.
Evaluating prior predictions of production and seismic data
Authors: Alfonzo Miguel , Oliver Dean S.
Published: October 2019

It is common in ensemble-based methods of history matching to evaluate the adequacy of the initial ensemble of models through visual comparison between actual observations and data predictions prior to data assimilation. If the model is appropriate, then the observed data should look plausible when compared to the distribution of realizations of simulated data. The principle of data coverage alone is, however, not an effective method for model criticism, as coverage can often be obtained by increasing the variability in a single model parameter. In this paper, we propose a methodology for determining the suitability of a model before data assimilation, particularly aimed for real cases with large numbers of model parameters, large amounts of data, and correlated observation errors. This model diagnostic is based on an approximation of the Mahalanobis distance between the observations and the ensemble of predictions in high-dimensional spaces. We applied our methodology to two different examples: a Gaussian example which shows that our shrinkage estimate of the covariance matrix is a better discriminator of outliers than the pseudo-inverse and a diagonal approximation of this matrix; and an example using data from the Norne field. In this second test, we used actual production, repeat formation tester, and inverted seismic data to evaluate the suitability of the initial reservoir simulation model and seismic model. Despite the good data coverage, our model diagnostic suggested that model improvement was necessary. After modifying the model, it was validated against the observations and is now ready for history matching to production and seismic data. This shows that the proposed methodology for the evaluation of the adequacy of the model is suitable for large realistic problems.
Acceptability of intravenous propofol sedation for adolescent dental care
Authors: Dixon C. , Aspinall A. , Rolfe S. , Stevens C.
Published: October 2019

Purpose

Propofol is an intravenous anaesthetic agent commonly utilised in general anaesthesia, however in sub-anaesthetic concentrations can be utilised to provide sedation through automated dosing of target-controlled infusion (TCI). TCI has been shown to provide accurate and stable predicted plasma and effect-site concentrations of propofol. A four-part mixed-method prospective study was undertaken to evaluate the safety and patient acceptability of intravenous propofol sedation in adolescent patients requiring dental care. There is a paucity in the literature on patient-reported outcomes and patient safety in the management of adolescent patients for dental treatment.

Methods

Demographics were recorded including age, gender, ASA Classification and Children’s Fear Survey Schedule—Dental Subscale (CFSS-DS) completed pre-operatively. Behaviour ratings of the Frankl and Houpt scales were recorded followed by post-operative questionnaire and telephone consultation. Consultation was completed following the procedure to determine patient satisfaction, memory of the procedure and any reported side effects of treatment. Qualitative thematic analysis was utilised.

Results

55 patients were recruited for the study, of which 49 (mean age 14.67 years) completed the sedation study and were treated safely with no post-operative complications. The mean lowest oxygen saturation was 98.12% SpO2 (SD 2.6). Thematic analysis demonstrated positive patient-reported outcomes to IV sedation.

Conclusion

Propofol TCI sedation is an effective treatment modality for the management of dentally anxious adolescents as a safe alternative to general anaesthesia, allowing the opportunity for increased provision of treatment per visit on those patients with a high dental need. Further randomised controlled trials comparing propofol TCI to other pharmacological managements are required.
Fooled by Rounding
Authors: Mason John , Zazkis Rina
Published: October 2019

For any convex quadrilateral, joining each vertex to the mid-point of the next-but-one edge in a clockwise direction produces an inner quadrilateral (as does doing so in a counter-clockwise direction). In many cases, a dynamic geometry measurement of the ratio of the area of the outer quadrilateral to the area of the inner one appears to be 5:1. It turns out, however, that this is due to rounding. We generalise the construction by replacing mid-points by more general ratios, finding the maximum and minimum values of the area ratio and determining the conditions on the original quadrilateral that achieve those two extremes.
Effects of plant extracts and essential oils on the behavior of Acrobasis advenella (Zinck.) caterpillars and females
Authors: Magierowicz Klaudia , Górska-Drabik Edyta , Golan Katarzyna
Published: October 2019

At present,Acrobasis advenella(Zinck.) (Lepidoptera, Pyralidae) is the most dangerous pest of black chokeberry (Aronia melanocarpa[Michx.] Elliot). Damaged flower buds may decrease yield, while pest feeding inside fruits causes deterioration in their quality. The aim of the study was to determine and compare the effect of water and acetone plants extracts and essential oils using free choice tests of feeding site of larvae and oviposition of females. The following species were examined:Achillea millefolium,Cymbopogon citratus,Nepeta cataria,Origanum vulgare,Satureja hortensis,Tagetes patula nana,Tanacetum vulgareandThymus vulgaris. The results showed that plant species had a significant influence on the choice of oviposition and feeding site ofA. advenella. Moreover, the type of formulation affected the number of laid eggs. Females did not lay eggs on infructescences treated with acetone extracts. Among the test preparations, the highest percentage larvae and adults ofA. advenellawas recorded for plants soaked inC. citratus, and therefore it can be a potential attractant for this pest species. The lowest number of eggs and larvae was observed forT. vulgare.
Uniformly perfect finitely generated simple left orderable groups
Authors: HYDE JAMES , LODHA YASH , NAVAS ANDRÉS , RIVAS CRISTÓBAL
Published: October 2019

We show that the finitely generated simple left orderable groups $G_{\!\unicode[STIX]{x1D70C}}$ constructed by the first two authors in Hyde and Lodha [Finitely generated infinite simple groups of homeomorphisms of the real line. Invent. Math. (2019), doi:10.1007/s00222-019-00880-7] are uniformly perfect—each element in the group can be expressed as a product of three commutators of elements in the group. This implies that the group does not admit any homogeneous quasimorphism. Moreover, any non-trivial action of the group on the circle, which lifts to an action on the real line, admits a global fixed point. It follows that any faithful action on the real line without a global fixed point is globally contracting. This answers Question 4 of the third author [A. Navas. Group actions on 1-manifolds: a list of very concrete open questions. Proceedings of the International Congress of Mathematicians, Vol. 2. Eds. B. Sirakov, P. Ney de Souza and M. Viana. World Scientific, Singapore, 2018, pp, 2029–2056], which asks whether such a group exists. This question has also been answered simultaneously and independently, using completely different methods, by Matte Bon and Triestino [Groups of piecewise linear homeomorphisms of flows. Preprint, 2018, arXiv:1811.12256]. To prove our results, we provide a characterization of elements of the group $G_{\!\unicode[STIX]{x1D70C}}$ which is a useful new tool in the study of these examples.
Theatre Policies of Soviet Stalinism and Italian Fascism Compared, 1920–1940s
Authors: Golovlev Alexander
Published: October 2019

In this article Alexander Golovlev offers a comparative examination of the theatre policies of Fascist Italy and Stalinist Soviet Union. He argues that, although the two regimes shared parallel time frames and gravitated around similar institutional solutions, Italian Fascism was fundamentally different in its reluctance to destroy the privately based theatre structure in favour of a state theatre and to impose a unified style, while Stalin carried out an ambitious and violent campaign to instil Socialist Realism through continuous disciplining, repression, and institutional supervision. In pursuing a nearly identical goal of achieving full obedience, the regimes used different means, and obtained similarly mixed results. While the Italian experience ended with the defeat of Fascism, Soviet theatres underwent de-Stalinization in the post-war decades, indicating the potential for sluggish stability in such frameworks of cultural-political control. Alexander Golovlev is Research Fellow at the International Centre for the History and Sociology of World War II and Its Consequences, National Research University, Higher School of Economics / Fondation de la Maison des Sciences de l’Homme, and ATLAS Fellow, Centre d’histoire culturelle des sociétés contemporaines, Université de Versailles-Saint-Quentin-en-Yvelines/ Université Paris-Saclay. His most recent publications include ‘Sounds of Music from across the Sea: Musical Transnationality in Early Post-World-War-II Austria’, in Yearbook of Transnational History 1 (2018) and ‘Von der Seine an die Salzach: die Teilnahme vom Straßburger Domchor an den Salzburger Festspielen und die französische Musikdiplom atie in Österreich während der alliierten Besatzungs zeit’, Journal of Austrian Studies (2018). He is currently working on the political economy of the Bolshoi theatre under Stalinism.
Pressurizing the Politics of The Crucible: a Brechtian Production of Arthur Miller’s Modern Classic
Authors: Barnett David
Published: October 2019

In this article David Barnett documents a practice-as-research project that employed Brechtian approaches to stage dramatic material. The Crucible by Arthur Miller is a realist text in which the protagonist, John Proctor, redeems himself for the sin of adultery by taking a heroic stand against the Salem witch-hunts. Existing scholarship has revealed a series of gendered biases in the form and content of the play, yet these findings have never been systematically realized in performance. While appearing to defend democratic values, the play’s dramaturgical strategies coerce agreement, and this represents a fundamental contradiction. Brecht offers a method that preserves the written dialogue, but interprets it critically onstage, deploying a range of devices derived from a materialist and dialectical interpretation. The aim of the production was to re-present a play with a familiar production history and problematize the political bases on which it conventionally rested. The article discusses the rationale for the theory and practice of contemporary Brechtian theatre and offers the production as a model for future critical realizations of other realist plays. David Barnett is Professor of Theatre at the University of York. His publications include A History of the Berliner Ensemble (CUP, 2015), Brecht in Practice: Theatre, Theory and Performance (Bloomsbury, 2014), amd Rainer Werner Fassbinder and the German Theatre (CUP, 2005).
Channelling Intergenerational Desire in Catherine Johnson’s Mamma Mia!
Authors: Chandler David
Published: October 2019

In this article, David Chandler challenges the often dismissive interpretation of Catherine Johnson’s hugely successful Mamma Mia! (1999) as a sunny, upbeat, lightweight musical. Johnson’s earlier dramatic work was of a more serious cast, and returned repeatedly to scenes of damaging, often exploitative, intergenerational desire. This interest continues in Mamma Mia! though commercial imperatives meant it had to be suppressed and displaced. As Sophie, the heroine, secretly meets the three middle-aged men who could be her father, but who have no idea she may be their daughter, the danger that they may be sexually attracted to her – one of them quickly labels her a ‘minx’ – becomes a subter ranean force shaping the fates of most of the central protagonists and the final surprise irresolution of the paternity plot. Intergenerational relationships blossom in Mamma Mia!, but they are treated differently from the relationships between couples of similar ages. David Chandler is a professor in the English Department at Doshisha Univ er sity, Kyoto. His background is in literary Romanticism, but since 2008 he has also pub lished widely on the history of musical theatre in Britain. He is a director of Retrospect Opera.
Edward Gordon Craig’s Continuity of Life, Mind, and Spirit: a Cognitive View
Authors: Murphy Maiya
Published: October 2019

In this article Maiya Murphy uses the enactive paradigm of cognition to take a fresh look at Edward Gordon Craig’s experiments in the theatre. By focusing on his obsession with movement, Maiya Murphy argues that an autopoietic conception of life can recategorize his problems with, ideas about, and experiments in the theatre as a coherent but multifaceted effort to create a very particular kind of cognitive engagement. She explores how enaction’s concept of the continuity of life and mind can map out a meaningful logic embedded in Craig’s intuitions about the connections between cognition, aesthetic experience, epistemology, and ontology. She also considers how the many media in which he worked and his interest in Asian arts – along with his major concepts such as the übermarionette and the kinetic stage – can be seen as attempts to think through theatre as an embodied and emergent event that is at once concrete, aesthetic, cognitive, and metaphysical. Finally, she traces the philosophical heritages that gave Craig his frameworks for understanding movement, arguing that his limitations and frustrations were fundamentally philosophical. Maiya Murphy is an Assistant Professor in the Theatre Programme at the National University of Singapore and makes theatre with her movementbased collective, Autopoetics. She is author of Enacting Lecoq: Movement in Theatre, Cognition, and Life (Palgrave Macmillan, 2019), and of essays in Theatre Survey and The Routledge Companion to Jacques Lecoq, among others.
Long Monotone Trails in Random Edge-Labellings of Random Graphs
Authors: Angel Omer , Ferber Asaf , Sudakov Benny , Tassion Vincent
Published: October 2019

Given a graph G and a bijection f : E(G) → {1, 2,…,e(G)}, we say that a trail/path in G is f-increasing if the labels of consecutive edges of this trail/path form an increasing sequence. More than 40 years ago Chvátal and Komlós raised the question of providing worst-case estimates of the length of the longest increasing trail/path over all edge orderings of Kn. The case of a trail was resolved by Graham and Kleitman, who proved that the answer is n-1, and the case of a path is still wide open. Recently Lavrov and Loh proposed studying the average-case version of this problem, in which the edge ordering is chosen uniformly at random. They conjectured (and Martinsson later proved) that such an ordering with high probability (w.h.p.) contains an increasing Hamilton path.

In this paper we consider the random graph G = Gn,p with an edge ordering chosen uniformly at random. In this setting we determine w.h.p. the asymptotics of the number of edges in the longest increasing trail. In particular we prove an average-case version of the result of Graham and Kleitman, showing that the random edge ordering of Kn has w.h.p. an increasing trail of length (1-o(1))en, and that this is tight. We also obtain an asymptotically tight result for the length of the longest increasing path for random Erdős-Renyi graphs with p = o(1).
The paradox of state identification:de factostates, recognition, and the (re-)production of the international
Authors: Grzybowski Janis
Published: October 2019

The literature onde factostates challenges the conventional identification of states by legal recognition, proposing to identify states based on their effectiveness instead. Yet, as I argue in this paper, rather than turning the tables on recognition, thede factostate challenge ultimately reveals all state identification in International Relations and international law to be essentially indeterminate. This lacuna, I suggest, is not an accidental omission, but an expression of the foundational paradox of modern political order that is rooted in the intertwined ontology of the state system and the individual states constituting it, with each presupposing the other. As a result, the opposition between empirical facts, political decisions, and legal norms invoked in attempts to identify states cannot but remain irresolvable. This should not be regarded as a problem to be overcome, however, but as a source of social order. Although states cannot be substantively identified, any effort to do so in practice naturalizes the state as the very form through which we articulate and shape political claims, conflicts, and settlements. In performatively enacting states precisely at the contested margins, state identification thus both invokes and (re-)produces the statist international as the central imaginary of modern political order.
Ocean-Based Actions Provide Big Opportunities to Curb Emissions
Authors: Showstack Randy
Published: October 2019

A new report outlines key areas to help mitigate emissions, including increased renewable energy, more efficient ocean-based transport, and advances in managing fisheries and aquaculture.
Comparative efficacy and safety of chlorthalidone and hydrochlorothiazide—meta-analysis
Authors: Dineva Stela , Uzunova Katya , Pavlova Velichka , Filipova Elena , Kalinov Krassimir , Vekov Toni
Published: October 2019

Hypertension is a complex syndrome of multiple hemodynamic, neuroendocrine, and metabolic abnormalities. The goals of treatment in hypertension are to optimally control high blood pressure and to reduce associated cardiovascular morbidity and mortality using the most suitable therapy available. Hydrochlorothiazide (HCTZ) and chlorthalidone (CTLD) are with proven hypertensive effects. The topic of our meta-analysis is to compare the efficacy of HCTZ and CTLD therapy in patient with hypertension. A search of electronic databases PubMed, MEDLINE, Scopus, PsyInfo, eLIBRARY.ru was performed. We chose the random-effects method for the analysis and depicted the results as forest plots. Sensitivity analyses were performed in order to evaluate the degree of significance of each study. Of the 1289 identified sources, only nine trials directly compared HCTZ and CTLD and were included in the meta-analysis. Changes in SBP lead to WMD (95% CI) equal to −3.26 mmHg showing a slight but statistically significant prevalence of CTLD. Results from analyzed studies referring to DBP lead to WMD (95% CI) equal to −2.41 mmHg, which is also statistically significant. During our analysis, we found that there were not enough studies presenting enough data on the effect of CTLD and HCTZ on levels of serum potassium and serum sodium. Our meta-analysis has demonstrated a slight superiority for CTLD regarding blood pressure control. At the same time, the two medications do not show significant differences in their safety profile.
Correction: Active PLK1-driven metastasis is amplified by TGF-β signaling that forms a positive feedback loop in non-small cell lung cancer
Authors: Shin Sol-Bi , Jang Hay-Ran , Xu Rong , Won Jae-Yeon , Yim Hyungshin
Published: October 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Integrated genome-wide methylation and expression analyses reveal functional predictors of response to antidepressants
Authors: Ju Chelsey , Fiori Laura M. , Belzeaux Raoul , Theroux Jean-Francois , Chen Gary Gang , Aouabed Zahia , Blier Pierre , Farzan Faranak , Frey Benicio N. , Giacobbe Peter , Lam Raymond W. , Leri Francesco , MacQueen Glenda M. , Milev Roumen , Müller Daniel J , Parikh Sagar V. , Rotzinger Susan , Soares Claudio N. , Uher Rudolf , Li Qingqin , Foster Jane A. , Kennedy Sidney H. , Turecki Gustavo
Published: October 2019

Major depressive disorder (MDD) is primarily treated with antidepressants, yet many patients fail to respond adequately, and identifying antidepressant response biomarkers is thus of clinical significance. Some hypothesis-driven investigations of epigenetic markers for treatment response have been previously made, but genome-wide approaches remain unexplored. Healthy participants (n = 112) and MDD patients (n = 211) between 18–60 years old were recruited for an 8-week trial of escitalopram treatment. Responders and non-responders were identified using differential Montgomery-Åsberg Depression Rating Scale scores before and after treatment. Genome-wide DNA methylation and gene expression analyses were assessed using the Infinium MethylationEPIC Beadchip and HumanHT-12 v4 Expression Beadchip, respectively, on pre-treatment peripheral blood DNA and RNA samples. Differentially methylated positions (DMPs) located in regions of differentially expressed genes between responders (n = 82) and non-responders (n = 95) were identified, and technically validated using a targeted sequencing approach. Three DMPs located in the genesCHN2(cg23687322,p = 0.00043 and cg06926818,p = 0.0014) andJAK2(cg08339825,p = 0.00021) were the most significantly associated with mRNA expression changes and subsequently validated. Replication was then conducted with non-responders (n = 76) and responders (n = 71) in an external cohort that underwent a similar antidepressant trial. OneCHN2site (cg06926818;p = 0.03) was successfully replicated. Our findings indicate that differential methylation at CpG sites upstream of theCHN2andJAK2TSS regions are possible peripheral predictors of antidepressant treatment response. Future studies can provide further insight on robustness of our candidate biomarkers, and greater characterization of functional components.
Pomalidomide and dexamethasone combination with additional cyclophosphamide in relapsed/refractory multiple myeloma (AMN001)—a trial by the Asian Myeloma Network
Authors: Soekojo Cinnie Yentia , Kim Kihyun , Huang Shang-Yi , Chim Chor-Sang , Takezako Naoki , Asaoku Hideki , Kimura Hideo , Kosugi Hiroshi , Sakamoto Junichi , Gopalakrishnan Sathish Kumar , Nagarajan Chandramouli , Wei Yuan , Moorakonda Rajesh , Lee Shu Ling , Lee Je Jung , Yoon Sung-Soo , Kim Jin Seok , Min Chang Ki , Lee Jae-Hoon , Durie Brian , Chng Wee Joo
Published: October 2019

Pomalidomide is a third generation immunomodulatory drug which in combination with dexamethasone, has been shown to be active in relapsed/refractory multiple myeloma. However, the data in Asian patients remain limited. We conducted a prospective phase two clinical trial in major cancer centers in Singapore, South Korea, Taiwan, Japan and Hong Kong to assess the efficacy and safety of pomalidomide and dexamethasone combination (PomDex) +/− cyclophosphamide in Asian patients with relapsed/refractory multiple myeloma who failed lenalidomide and bortezomib. Patients were treated with pomalidomide (4 mg daily for 21 days every 4 weeks) and dexamethasone (40 mg weekly). If there is less than a minimal response after three cycles of PomDex, cyclophosphamide 300 mg/m2 can be added (PomCyDex). A total of 136 patients were enrolled. The median PFS was 9 and 10.8 months for the PomDex and PomCyDex group, respectively. The median OS was 16.3 months. This regimen appears to be active across age groups and prior lines of treatment. This combination was overall well tolerated with grade 3 and 4 adverse events of mainly cytopenias. PomDex is highly active and well-tolerated in Asian patients. The addition of cyclophosphamide can improve the response and outcomes further in patients with suboptimal response to PomDex.
Two may be better than one: PD-1/PD-L1 blockade combination approaches in metastatic breast cancer
Authors: Page David B. , Bear Harry , Prabhakaran Sangeetha , Gatti-Mays Margaret E. , Thomas Alexandra , Cobain Erin , McArthur Heather , Balko Justin M. , Gameiro Sofia R. , Nanda Rita , Gulley James L. , Kalinsky Kevin , White Julia , Litton Jennifer , Chmura Steven J. , Polley Mei-Yin , Vincent Benjamin , Cescon David W. , Disis Mary L. , Sparano Joseph A. , Mittendorf Elizabeth A. , Adams Sylvia
Published: October 2019

Antibodies blocking programmed death 1 (anti-PD-1) or its ligand (anti-PD-L1) are associated with modest response rates as monotherapy in metastatic breast cancer, but are generally well tolerated and capable of generating dramatic and durable benefit in a minority of patients. Anti-PD-1/L1 antibodies are also safe when administered in combination with a variety of systemic therapies (chemotherapy, targeted therapies), as well as with radiotherapy. We summarize preclinical, translational, and preliminary clinical data in support of combination approaches with anti-PD-1/L1 in metastatic breast cancer, focusing on potential mechanisms of synergy, and considerations for clinical practice and future investigation.
The ENERTALK dataset, 15 Hz electricity consumption data from 22 houses in Korea
Authors: Shin Changho , Lee Eunjung , Han Jeongyun , Yim Jaeryun , Rhee Wonjong , Lee Hyoseop
Published: October 2019

AMI has been gradually replacing conventional meters because newer models can acquire more informative energy consumption data. The additional information has enabled significant advances in many fields, including energy disaggregation, energy consumption pattern analysis and prediction, demand response, and user segmentation. However, the quality of AMI data varies significantly across publicly available datasets, and low sampling rates and numbers of houses monitored seriously limit practical analyses. To address these challenges, we herein present the ENERTALK dataset, which contains both aggregate and per-appliance measurements sampled at 15 Hz from 22 houses. Among the publicly available datasets with both aggregate and per-appliance measurements, 15 Hz was the highest sampling rate. The number of houses (22) was the second-largest where the largest one had a sampling rate of 1 Hz. The ENERTALK dataset is also the first Korean open dataset on residential electricity consumption.
Author Correction: Relativistic Doppler-boosted γ-rays in High Fields
Authors: Capdessus Remi , King Martin , Sorbo Dario Del , Duff Matthew , Ridgers Christopher P. , McKenna Paul
Published: October 2019

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Author Correction: A Monte Carlo feasibility study for neutron based real-time range verification in proton therapy
Authors: Ytre-Hauge Kristian Smeland , Skjerdal Kyrre , Mattingly John , Meric Ilker
Published: October 2019

An amendment to this paper has been published and can be accessed via a link at the top of the paper.
Generalizing the inverse FFT off the unit circle
Authors: Sukhoy Vladimir , Stoytchev Alexander
Published: October 2019

This paper describes the first algorithm for computing the inverse chirp z-transform (ICZT) inO(n log n) time. This matches the computational complexity of the chirp z-transform (CZT) algorithm that was discovered 50 years ago. Despite multiple previous attempts, an efficient ICZT algorithm remained elusive until now. Because the ICZT can be viewed as a generalization of the inverse fast Fourier transform (IFFT) off the unit circle in the complex plane, it has numerous practical applications in a wide variety of disciplines. This generalization enables exponentially growing or exponentially decaying frequency components, which cannot be done with the IFFT. The ICZT algorithm was derived using the properties of structured matrices and its numerical accuracy was evaluated using automated tests. A modification of the CZT algorithm, which improves its numerical stability for a subset of the parameter space, is also described and evaluated.
Understanding the attitude of others by hearing action sounds: the role of the insula
Authors: Di Cesare G. , Marchi M. , Pinardi C. , Rizzolatti G.
Published: October 2019

During social interactions, actions and words can be expressed in different ways, for example gently, vigorously or rudely communicating the positive or negative attitude of the agent. These forms of communication are called vitality forms and play a crucial role in social relations. While the neural bases of speech and actions vitality forms have been investigated, there is no information on how we recognize others’ mood/attitude by hearing the sound of their actions. In the present fMRI study we investigated the neural basis of vitality forms while participants heard action sounds in two different conditions: sounds resulting from gentle and rude actions, sounds communicating the same actions without vitality forms (control stimuli). Results showed that hearing action sounds conveying rude and gentle vitality forms respect to the control stimuli produced a specific activation of the dorso-central insula. In addition, hearing both vitality forms action sounds and control stimuli produced the activation of the parieto-frontal circuit typically involved in the observation and the execution of arm actions. In conclusion, our data indicate that, the dorso-central insula is a key region involved in the processing of vitality forms regardless of the modality by which they are conveyed.
Hemophilia A and B mice, but not VWF−/−mice, display bone defects in congenital development and remodeling after injury
Authors: Taves Sarah , Sun Junjiang , Livingston Eric W. , Chen Xin , Amiaud Jerome , Brion Regis , Hannah William B. , Bateman Ted A. , Heymann Dominique , Monahan Paul E.
Published: October 2019

While joint damage is the primary co-morbidity of hemophilia, osteoporosis and osteopenia are also observed. Coagulation factor VIII deficient (FVIII−/−) mice develop an osteoporotic phenotype in the absence of induced hemarthrosis that is exacerbated two weeks after an induced joint injury. Here we have compared comprehensively the bone health of clotting factor VIII, factor IX, and Von Willebrand Factor knockout (FVIII−/−, FIX−/−, and VWF−/− respectively) mice both in the absence of joint hemorrhage and following induced joint injury. We found FVIII−/− and FIX−/− mice, but not VWF−/− mice, developmentally have an osteoporotic phenotype. Unilateral induced hemarthrosis causes further bone damage in both FVIII−/− and FIX−/− mice, but has little effect on VWF−/− bone health, indicating that the FVIII.VWF complex is not required for normal bone remodeling in vivo. To further investigate the bone healing following hemarthrosis in hemophilia we examined a two week time course using microCT, serum chemistry, and histological analysis. Elevated ratio of osteoprotegerin (OPG)/receptor activator of nuclear factor-kappa B ligand (RANKL), increased osterix+ osteoblastic cells, and decreased smoothness of the cortical bone surface were evident within several days of injury, indicative of acute heterotopic mineralization along the cortical surface. This was closely followed by increased interleukin-6 (IL-6) levels, increased osteoclast numbers, and significant trabecular bone loss. Uncoupled and disorganized bone formation and resorption continued for the duration of the study resulting in significant deterioration of the joint. Further elucidation of the shared mechanisms underlying abnormal bone homeostasis in the absence of FVIII or FIX is needed to guide evidence-based approaches to the screening and treatment of the prevalent bone defects in hemophilia A and B.