bluuebunny/crossref_metadata_2025 huggingface dataset:
Receita tradicional russa adaptada para dietas com restrição de sódio, gordura saturada e colesterol
Authors: Devincenzi Macarena Urrestarazu , Modesto Simone Paula , Silva Maria Elisabeth Machado Pinto e
Published: April 2011

Estudos prospectivos sobre doença isquêmica do coração detectaram fatores de risco para a doença coronariana: idade, sexo, presença de hipertensão arterial sistêmica, níveis elevados de colesterol sérico e tabagismo. Os três últimos podem ser modificados por meio de intervenções dietéticas, farmacológicas e/ou comportamentais. O potencial de uma dieta, ou de um alimento em aumentar os níveis plasmáticos de colesterol e promover aterosclerose está diretamente relacionado com seu conteúdo de colesterol e gordura saturada. Indivíduos com dietas restritas em sódio, colesterol e gordura saturada não devem consumir estrogonofe de carne, preparação tradicional russa de uso em nossa população, por conter os ingredientes: manteiga, sal e creme de leite. A fim de permitir a esses pacientes o consumo de estrogonofe e com menor teor desses nutrientes foram feitas adaptações como a substituição do creme de leite por leite desnatado e amido, da manteiga por óleo vegetal e do sal por outros condimentos. A receita modificada obteve redução no seu valor calórico, de lipídios, colesterol, sódio e gordura saturada e aumento no teor protéico e de ácidos graxos poliinsaturados. Essa receita foi avaliada sensorialmente pelo método de escala hedônica, tendo sido aprovada por 78% dos provadores e identificada como estrogonofe por mais de 90%. Estes resultados mostram que podem ser realizados experimentos com substituições de ingredientes em receitas e com sucesso, a fim de atender às especificidades de cada dieta.
Produção agronômica de uma coleção de acessos de Paspalum nicorae Parodi
Authors: Pereira Emerson André , Dall'Agnol Miguel , Nabinger Carlos , Huber Kátia Graziela Costa , Montardo Daniel Portella , Genro Teresa Cristina Moraes
Published: April 2011

Este estudo foi realizado para avaliar uma coleção de 53 acessos de Paspalum nicorae, estabelecidos em duas regiões fisiograficamente distintas durante dois anos, buscando caracterizar a produção e qualidade de forragem dos acessos para etapas subsequentes em programa de melhoramento de plantas forrageiras. Os acessos foram estabelecidos em linhas, num delineamento de blocos casualizados com três repetições, e as avaliações foram realizadas de outubro de 2007 a fevereiro de 2009 por meio de cortes. Houve variação da produção de forragem entre os acessos ao longo do tempo e entre os locais. A maioria dos acessos de P. nicorae apresentou elevado rendimento de forragem em comparação à testemunha (P. notatum cv. Pensacola) e alguns acessos apresentaram desempenho bem expressivo. Os percentuais de proteína bruta obtidos nos acessos da coleção foram semelhantes aos encontrados na testemunha. Os acessos 28B e 26A de P. nicorae são indicados para etapas subsequentes de um programa de melhoramento de plantas forrageiras.
Desempenho e tamanho de vísceras de cordeiros Santa Inês após ganho compensatório
Authors: Almeida Thais Romano de Vasconcelos e , Perez Juan Ramon Olalquiaga , Chlad Mônica , França Patrícia Maria de , Leite Rafael Fernandes , Nolli Cristine Paduan
Published: April 2011

Objetivou-se avaliar o crescimento, o desempenho e o tamanho das vísceras de cordeiros Santa Inês após ganho compensatório. Foram utilizados 22 animais de duas faixas de peso vivo inicial, leves (33,5 kg) e pesados (56,8 kg), distribuídos em três regimes alimentares: controle, com consumo à vontade; restrição alimentar, com consumo para manutenção do peso vivo; e crescimento compensatório, com restrição alimentar e posterior consumo à vontade até peso vivo semelhante ao dos animais controle, quando foram abatidos. As dietas experimentais, constituídas de feno de capim Coast-cross (Cynodon dactylon) moído e concentrado composto de farelo de soja (Glicine max L.), milho (Zea mays L.), polpa cítrica, ureia pecuária e suplemento mineral e vitamínico, atenderam às necessidades nutricionais para os diferentes objetivos. Os animais em restrição alimentar apresentaram os piores resultados de peso vivo final, consumo de matéria seca, ganho de peso, conversão alimentar e peso relativo do fígado, enquanto, naqueles em crescimento compensatório, o peso vivo final, a conversão alimentar e o peso de fígado foram semelhantes aos dos animais em crescimento contínuo. O consumo entre os animais pesados em crescimento contínuo foi superior ao daqueles mantidos nos demais regimes alimentares. No grupo de animais leves em crescimento compensatório, o ganho de peso foi maior que naqueles em crescimento contínuo e, nesses dois grupos, foi superior ao dos animais em restrição alimentar. Os animais pesados, no entanto, apresentaram ganho de peso vivo semelhante ao dos animais controle. Cordeiros podem apresentar crescimento compensatório, que depende do grau de maturidade dos animais.
Estabilidade dos potenciais evocados auditivos em indivíduos adultos com audição normal
Authors: Matas Carla Gentile , Hataiama Natália Moribe , Gonçalves Isabela Crivellaro
Published: April 2011

OBJETIVO: Avaliar a estabilidade dos parâmetros dos potenciais evocados auditivos em adultos normais. MÉTODOS: Foram submetidos à avaliação audiológica e eletrofisiológica (potencial evocado auditivo de tronco encefálico - PEATE, potencial evocado auditivo de média latência - PEAML e potencial cognitivo - P300) 49 indivíduos normais, de 18 a 40 anos (25 do gênero feminino e 24 do gênero masculino). Realizou-se reavaliação três meses após a avaliação. RESULTADOS: Foram observadas diferenças entre os gêneros na avaliação para as latências das ondas III e V e interpicos I-III e I-V do PEATE e amplitude N2-P3 do P300. Não foram verificadas diferenças significativas para os parâmetros do PEATE, PEAML (latência das ondas Na, Pa e amplitude Na - Pa) e P300 (latência da onda P300) entre os resultados obtidos na avaliação e reavaliação. CONCLUSÃO: Exceção feita à amplitude N2-P3, observou-se estabilidade dos parâmetros de PEATE, PEAML e P300 em adultos normais após período de três meses.
Condicionantes estruturais dos relacionamentos intraorganizacionais: uma análise da influência sobre relações de comunicação e decisão
Authors: Santos Luis Gabriel Abravanel dos , Rossoni Luciano , Machado-da-Silva Clóvis Luiz
Published: April 2011

O presente trabalho tem como objetivo analisar as relações intraorganizacionais de comunicação e de tomada de decisão estabelecidas entre gerentes de uma organização industrial. Partindo de aspectos conceituais delineados na teoria das organizações e em teorias sobre redes sociais, buscamos, em primeiro lugar, avaliar como a estrutura formal condiciona as relações de comunicação e de tomada de decisão. Depois, avaliamos como a estrutura departamental define os padrões de homofilia e heterofilia. Por fim, avaliamos como os aspectos formais do cargo, as características pessoais e a posição na rede estão associados com o prestígio dos gerentes. Nos resultados, destacamos que, entre as relações formais, aquela que apresenta maior condicionamento sobre as relações naturais é a relação hierárquica, e ela condiciona muito mais as escolhas instrumentais (tomada de decisão) que as escolhas sociais (comunicação). Observamos também que o departamento de produção apresenta tendência de segregação ou homofilia, enquanto os demais departamentos apresentam tendência de diferenciação ou heterofilia. Por fim, buscando compreender os antecedentes do prestígio dos gerentes, identificamos que, entre as variáveis de redes, aquelas que apontam para a formação de capital social por meio dos laços fracos mostraram-se mais fortemente relacionadas com prestígio na tomada de decisão do que aquelas que indicam capital social por meio dos laços fortes.
Tempos de espera no Supremo Tribunal Federal
Authors: Abramo Claudio Weber
Published: April 2011

Expõe-se um método de medir o desempenho de magistrados na decisão de processos judiciais. A estratégia é usada para construir uma ferramenta de monitoramento voltada para o Supremo Tribunal Federal brasileiro. A medida de tempos médios de espera na decisão de causas que tramitam na Corte pode ajudar na formulação de intervenções administrativas destinadas a reduzi-los. A comparação entre as médias observadas em diferentes classes processuais e ramos do Direito pode ajudar a compreender melhor os fatores subjetivos em jogo nas decisões judiciais. A comparação dos desempenhos de magistrados individuais ajuda a melhorar o sistema pelo uso de penalidades reputacionais. A partir do método constata-se que juízes reagem a processos judiciais da mesma forma que sistemas biológicos, mecânicos e eletrônicos reagem a estímulos. A forma assumida pelas distribuições de tempo de decisão medidas ajuda a explicar o pessimismo das percepções populares a respeito da celeridade do judiciário.
Características oclusais de pacientes com Classe II, divisão 1, tratados sem e com extrações de dois pré-molares superiores
Authors: Graciano João Tadeu Amin , Janson Guilherme , Freitas Marcos Roberto de , Henriques José Fernando Castanha
Published: April 2011

OBJETIVOS: o objetivo deste estudo foi identificar características oclusais iniciais de pacientes Classe II, divisão 1, tratados sem e com extrações de dois pré-molares superiores. MÉTODOS: foram selecionados 62 pacientes que apresentavam má oclusão de Classe II, divisão 1, os quais foram divididos em dois grupos, de acordo com a forma de tratamento proposta, sendo o grupo 1 constituído de 42 pacientes (23 do sexo feminino e 19 do sexo masculino), com idade média de 12,7 anos, tratados sem extrações e com aparelho fixo combinado com extrabucal; e o grupo 2, composto de 20 pacientes (6 do sexo feminino e 14 do sexo masculino), com idade média de 13,5 anos, tratados também com aparelho fixo combinado com uso de extrabucal, mas que tiveram indicação de extrações de dois pré-molares superiores em seus planos de tratamento. Para observar as características oclusais iniciais e finais, assim como suas alterações com o tratamento, foi utilizado o Índice de Prioridade de Tratamento (IPT). Os valores dos índices foram submetidos à análise estatística pelo teste t independente, para comparar as variáveis entre os grupos. RESULTADOS E CONCLUSÕES: os resultados demonstraram que o grau de má oclusão inicial foi diferente nos dois grupos quando avaliados pelo IPT, sendo maior no grupo tratado com extrações de dois pré-molares superiores
Percepção das alterações no plano gengival na estética do sorriso
Authors: Feu Daniela , Andrade Fabíola Bof de , Nascimento Ana Paula Camata , Miguel José Augusto Mendes , Gomes Antonio Augusto , Capelli Júnior Jonas
Published: April 2011

OBJETIVO: esse estudo analisou a percepção de 80 profissionais de Odontologia e 80 indivíduos leigos, pacientes de consultórios particulares e da Faculdade de Odontologia da Universidade Federal do Espírito Santo, quanto à presença de alterações no plano gengival. MÉTODOS: a fotografia de uma mulher jovem sorrindo foi digitalmente modificada, produzindo alterações simétricas na altura gengival dos incisivos centrais e incisivos laterais, tornando o plano gengival progressivamente ascendente. Foi solicitado que os indivíduos escolhessem a foto mais agradável e, depois disso, o entrevistador questionava o indivíduo para verificar se o mesmo sabia o que estava sendo alterado na sequência de fotos, ou seja, se identificava as alterações feitas no plano gengival. RESULTADOS: os resultados mostraram que houve uma prevalência significativa na seleção do plano gengival harmonioso no grupo de dentistas e de pacientes (p<0,001; p<0,05, respectivamente) e que não houve diferenças significativas entre as especialidades integrantes do grupo de dentistas (p=0,538), o que aconteceu no grupo de leigos (p=0,05), demonstrando maior percepção do grupo de pacientes de consultório. A identificação da alteração no plano gengival foi significativa no grupo de dentistas (p<0,001) sem diferenças significativas dentre as especialidades do grupo, e não foi significativa no grupo de leigos (p=0,100). Foi evidenciada também uma identificação do problema significativamente superior no grupo de dentistas em relação ao grupo de leigos (p<0,001). CONCLUSÃO: concluiu-se, portanto, que alterações simétricas acima de 2mm podem ser percebidas por dentistas e leigos, que não existem diferenças nessa percepção entre as especialidades odontológicas estudadas e que o grupo de pacientes de consultório foi significativamente mais perceptivo que os pacientes da UFES.
A influência de imagens tridimensionais no plano de tratamento ortodôntico
Authors: Castro Iury Oliveira , Estrela Carlos , Valladares-Neto José
Published: April 2011

INTRODUÇÃO: a tomografia computadorizada de feixe cônico (TCFC) foi introduzida no final da década de 90 e estudos têm aprimorado o seu emprego na Odontologia. OBJETIVO: o objetivo desse artigo foi verificar a influência de imagens tridimensionais (3D) no plano de tratamento ortodôntico. MÉTODOS: duas situações clínicas (reabsorção cervical e deiscência óssea) foram descritas por meio de imagens 3D. RESULTADOS: a conduta ortodôntica foi redirecionada para a simplificação da mecânica e o controle das lesões durante o tratamento ortodôntico. CONCLUSÃO: imagens 3D são capazes de aumentar a acurácia do diagnóstico e redirecionar o plano de tratamento ortodôntico.
Avaliação do efeito da expansão rápida da maxila na via aérea superior, por meio da nasofibroscopia: descrição da técnica e relato de caso
Authors: Jorge Edmilsson Pedro , Santos-Pinto Ary dos , Gandini Júnior Luiz Gonzaga , Guariza Filho Odilon , Castro Anibal Benedito Batista Arrais Torres de
Published: April 2011

A finalidade deste artigo é avaliar o efeito da expansão rápida da maxila (ERM) na via aérea superior. Por intermédio de um caso clínico, será relatado como indivíduos com atresia da maxila e com comprometimento da função naso-respiratória podem beneficiar-se com a ERM. Para entender melhor as alterações morfológicas decorrentes do paciente com problemas respiratórios, deve-se conhecer a anatomia e a fisiologia do sistema respiratório. Entretanto, não se pode esquecer que o tratamento deste paciente é multidisciplinar, envolvendo o ortodontista, otorrinolaringologista e a fonoaudióloga.
Variation in Field Pea (Pisum sativum) Cultivars for Basal Branching and Weed Competition
Authors: Spies J. M. , Warkentin T. D. , Shirtliffe S. J.
Published: April 2011

Field pea cultivars often differ in weed competition. In several crop types branching has been cited as one of the characteristics conferring competition with weeds. The objective of this study was to determine the difference in weed competition among field pea cultivars differing in basal branching and other characteristics. Ten field pea cultivars with divergent basal branching ability were seeded at 50 plants m−2under weedy and weed-free conditions to evaluate their competition with weeds. Branching did not differ greatly between cultivars and was not associated with the weed competiveness of the field pea cultivars. The forage pea cultivars, which were leafed and had longer vines, were much more competitive than the semi-leafless grain cultivars. As a result, the forage cultivars were better able to suppress weeds and maintain their yield under weed presence. However, the absolute seed yield of the forage pea cultivars was low, making them a poor choice for seed production. Vine length and the leafy characteristic may be important genetic characteristics associated with competition in field pea cultivars.
A Single-Time Survey Method to Predict the Daily Weed Density for Weed Control Decision-Making
Authors: Masin Roberta , Vasileiadis Vasileios P. , Loddo Donato , Otto Stefan , Zanin Giuseppe
Published: April 2011

Decision-making processes must indicate if, how, and when weed control should be practiced. So far, Decision Support Systems (DSSs) for weed control to prevent crop yield losses can guide decisions on “if” and “how.” Experience shows that farmers need a DSS that can also guide when to treat, but this can only be done if the actual weed density observed in the field is known during the crop cycle. Emergence models allow the prediction of daily density, but precision depends on the survey date. This study focuses on the estimation of the date of the survey for the best prediction of the daily density throughout the crop cycle. The predicted daily density of each species can be used by DSSs without any further survey, saving time and money and improving the use of the DSSs. Results showed that the best date is when the actual density of each weed reaches or exceeds 50% emergence, and this is earlier than the critical point date, supporting the validity of the date estimation method. The possibility to provide specific advice for farmers considering a proper mortality rate of weed seedlings is then discussed. The ability to optimize the date of sampling can improve the reliability of decision-making tools for integrated weed management, in agreement with the European Union goal of sustainable use of pesticides and more environmentally sustainable cropping systems through the use of integrated pest management.
Effects of the maximum soil aggregates size and cyclic wetting–drying on the stiffness of a lime-treated clayey soil
Authors: TANG A.M. , VU M.N. , CUI Y.-J.
Published: April 2011

Lime treatment is a well-known technique to improve the mechanical response of clayey subgrades of road pavements or clayey soils used for embankment. Several studies show that lime treatment significantly modifies the physical and hydromechanical properties of compacted soils. Nevertheless, studies on the scale effect under climatic changes are scarce. Actually, wetting–drying cycles might significantly modify the microstructure of treated soils, giving rise to changes in hydromechanical properties. This modification could be dependent on the size of soil aggregates before lime treatment. In the present work, this scale effect was studied by investigating the stiffness of a compacted lime-treated clayey soil using bender elements. The studied soil was first air-dried and ground into a target maximum soil aggregates size (Dmax). For each aggregate size, the soil was humidified to reach the target water contents wi, then mixed with 3% of lime powder (mass of lime divided by mass of dried soil) prior to the static compaction at a dry density of 1·60 Mg/m3. Two initial water contents (wi = 14 and 18%) and four maximum soil aggregates sizes (Dmax = 0·4, 1·0, 2·0 and 5·0 mm) were considered. After the compaction, the soil specimen (50 mm in diameter and 50 mm high) was covered by plastic film in order to prevent soil moisture changes. The soil stiffness was then monitored at variable time intervals until reaching stabilisation. Afterwards, the soil specimen was subjected to full saturation followed by air-drying to come back to its initial water content. The results show that: (a) the soil stiffness after lime-treatment is significantly dependent on the aggregate size: the finer the aggregates the higher the soil stiffness; (b) the effect of initial water content on the stiffness is negligible; and (c) the wetting–drying cycles seem to slightly increase the soil stiffness in the case of lime-treated specimens and decrease the soil stiffness in the case of untreated specimens. Furthermore, when an intensive drying was applied reducing the soil water content lower than the initial level, the soil stiffness decreased drastically after the subsequent wetting.
Engaging the workforce to establish a safety-conscious culture
Authors: Corcoran John
Published: April 2011

In early summer of 2008 the site management team on the £130 million tunnelling contract in Belfast were faced with a problem. There had been an alarming increase in the accident frequency rate for the contract and there was no indication that the situation was likely to improve. The site team’s solution was to find ways of connecting with the workforce; to work together to improve the existing safety culture; and ultimately reduce the number of accidents. This paper describes the initiatives that were used to repair communications between the site management and the operatives, and, once things started to improve, how the lines of communication were kept open.
Educating engineers in the workplace
Authors: Clarke Barry G
Published: April 2011

In the UK an engineer has to complete an educational base and initial professional development in order to become professionally qualified. There are a number of pathways creating a flexible approach to achieve the necessary learning outcomes and development objectives. This flexible approach allows engineers to take advantage of opportunities that arise and to fit their education and training to their career path. A number of those pathways include an element of work-based learning in which the graduate uses opportunities in the work place to complete their education. This paper describes two pathways developed by the Joint Board of Moderators, which is the body that is responsible for accrediting educational programmes for civil, structural and highway engineers. The schemes are the employer-managed scheme aimed at those responsible for training and the self-managed scheme aimed at graduates who wish to manage their own education in the work place. The paper highlights the structure of the schemes, the plans to achieve the necessary learning outcomes and the means of assessing their level of competency.
Certain properties of meromorphically multivalent functions
Authors: Liu Jin-Lin
Published: April 2011

The object of this paper is to derive some interesting properties of certain meromorphically multivalent functions.
Interventional Pain Management using Fluoroscopy and Ultrasound Imaging Techniques
Authors: Evansa Irina , Vasilevskis Edgars , Aron Michail , Logina Inara , Vanags Indulis
Published: April 2011

Interventional Pain Management using Fluoroscopy and Ultrasound Imaging Techniques

Interventional injection therapies play a major role in the management of various pain conditions and are becoming an integral part of the multidisciplinary therapies required to improve and rehabilitate pain patients. Many of these procedures have historically been performed without imaging guidance. Imaging-guided techniques with fluoroscopy or ultrasound increase the precision of these procedures and help confirm needle placement. Imaging-guided techniques should lead to better results and reduced complication rates and they are now becoming more popular. These improvements are probably due in part also to better patient selection by experienced pain physicians.
Resection of the First Rib for Fibrous Dysplasia by Transmanubrial Approach
Authors: Silins Ints , Simanovica Ilze , Rone Ilga
Published: April 2011

Resection of the First Rib for Fibrous Dysplasia by Transmanubrial Approach

Primary tumours of the first rib remains a rarity, but the diagnosis and the surgical approach are quite challenging because of the anatomical difficulties in approaching it and the closeness of subclavian vessels. The anterior transmanubrial approach gives an excellent exposure, especially when approaching the anterior part of the first rib. Diagnosis quite often can be approved just by the histo-pathological examination of the resected specimen. We describe the management of such a case, when diagnosis of fibrous dysplasia was confirmed postoperatively.
Multislice Computed Tomography Imaging of Diverticultis Complication: Colovenous Fistula
Authors: Radzina Maija , Laganovskis Andris , Tirane Mara , Zvaigzne Ligita , Prieditis Peteris , Bruns Voldemars , Lugovska Svetlana
Published: April 2011

Multislice Computed Tomography Imaging of Diverticultis Complication: Colovenous Fistula

Acute colon pathology as diverticulitis is a frequent and important gastrointestinal disease, but the clinical diagnosis is often difficult to state. Several radiological studies have been used to assist in the diagnosis of acute diverticulitis (e.g. barium enema, ultrasound, and computed tomography (CT). Colovenous fistula is a rare complication of diverticulitis. We have analyzed MSCT imaging role in evaluation of such complicated form of diverticular disease.
"Lutembacher's Syndrome" - A Case Report
Authors: Ali SY , Rahman M , Islam M , Barman RC , Ali MY , Islam MMSU
Published: April 2011

Lutembacher's Syndrome is a rare heart disease comprises ASD (congenital) secundum with Mitral stenosis (Rheumatic origin). The patient Md. Mosharraf Hossain, 72 years old man, non diabetic, non hypertensive, smoker admitted in FMCH on 10.10.2010 with the complaints of respiratory distress and chest pain for 10 days. He had a previous history of Rheumatic fever in early childhood. There was history of recurrent attack of Rheumatic fever. Subsequently he developed MS from Rheumatic carditis. ASD was congenital in origin. If diagnosis could be done earlier, surgical closure of ASD with replacement of mitral valve bears a good prognostic value. Our patient is in elderly age and already developed pulmonary hypertension, operative procedure is not suitable. So the patient should be kept in conservative treatment. Key words: Lutembacher's syndrome; Atrial Septal Defect; Mitral stenosis; Septum primium; Septum secundum.   DOI: 10.3329/fmcj.v6i1.7414 Faridpur Med. Coll. J. 2011;6(1): 59-60
Pseudomyxoma Peritonei: A Case Report
Authors: Ahad MA , Kamal SM , Bakar MA , Ali M Yusuf
Published: April 2011

Pseudomyxoma peritonei (PMP) is an uncommon condition characterized by abundant extracellular mucinous material in the peritoneal cavity and tumoural implants on the peritoneal and epiploic surfaces. Aim of this case report is to create awareness among the clinicians regarding this uncommon disease presented with ascites and irregular masses in the abdomen. PMP is a rare disease, may be benign or malignant, presented with ascites and irregular masses in the abdomen which is infrequently encountered in our clinical practice. Key words: Pseudomyxoma peritonei; mucinous carcinomatosis; hyperthermic chemotherapy; gelatinous material; irregular masses DOI: 10.3329/fmcj.v6i1.7415 Faridpur Med. Coll. J. 2011;6(1): 61-63
2D-DIGE Proteomic Analysis of Changes in Estrogen/Progesterone-Induced Rat Breast Hyperplasia upon Treatment with the Mongolian Remedy RuXian-I
Authors: Wang Zhong-Chao , E Du , Batu De-Ligen , Saixi Ya-Latu , Zhang Bin , Ren Li-Qun
Published: April 2011

RuXian-I has traditionally been used as a remedy for breast hyperplasia in the Inner Mongolia Autonomous Region of China. As a first step toward the investigation of biomarkers associated with RuXian-I treatment, a proteome-wide analysis of rat breast tissue was conducted. First, rat breast hyperplasia was induced by injection of estradiol and progesterone. After treatment with RuXian-I, there is a marked decrease in the hyperplasia, as can be shown by decreases in the nipple diameter and the pathological changes in breast. Subsequently, we used an approach that integrates size-based 2D-DIGE, MALDI-TOF/TOF-MS, and bioinformatics to analyze data from the control group, the model group and the RuXian-I treatment group. Using this approach, seventeen affected proteins were identified. Among these, 15 (including annexin A1, annexin A2, superoxide dismutase [Mn], peroxiredoxin-1, translationally-controlled tumor protein and a B-crystallin) were significantly up-regulated in the model group and down-regulated upon treatment with RuXian-I, and two (Tpil protein and myosin-4) have the opposite change trend. The expression of annexin A1 was confirmed using immunohistochemistry. The expression of superoxide dismutase (SOD) activity was confirmed biochemically. These results indicated that RuXian-I treats rat breast hyperplasia through regulation of cell cycle, immune system, metabolic, signal transduction, etc. The differential expressions of these proteins (annexin A1, superoxide dismutase [Mn], alpha B-crystallins and translationally controlled tumor protein, among others) were associated with occurrence and metastasis of breast cancer. These findings might provide not only far-reaching valuable insights into the mechanism of RuXian-I action, but also leads for prognosis and diagnosis of breast hyperplasia and breast cancer.
Tightly Coupled Low Cost 3D RISS/GPS Integration Using a Mixture Particle Filter for Vehicular Navigation
Authors: Georgy Jacques , Noureldin Aboelmagd
Published: April 2011

Satellite navigation systems such as the global positioning system (GPS) are currently the most common technique used for land vehicle positioning. However, in GPS-denied environments, there is an interruption in the positioning information. Low-cost micro-electro mechanical system (MEMS)-based inertial sensors can be integrated with GPS and enhance the performance in denied GPS environments. The traditional technique for this integration problem is Kalman filtering (KF). Due to the inherent errors of low-cost MEMS inertial sensors and their large stochastic drifts, KF, with its linearized models, has limited capabilities in providing accurate positioning. Particle filtering (PF) was recently suggested as a nonlinear filtering technique to accommodate for arbitrary inertial sensor characteristics, motion dynamics and noise distributions. An enhanced version of PF called the Mixture PF is utilized in this study to perform tightly coupled integration of a three dimensional (3D) reduced inertial sensors system (RISS) with GPS. In this work, the RISS consists of one single-axis gyroscope and a two-axis accelerometer used together with the vehicle’s odometer to obtain 3D navigation states. These sensors are then integrated with GPS in a tightly coupled scheme. In loosely-coupled integration, at least four satellites are needed to provide acceptable GPS position and velocity updates for the integration filter. The advantage of the tightly-coupled integration is that it can provide GPS measurement update(s) even when the number of visible satellites is three or lower, thereby improving the operation of the navigation system in environments with partial blockages by providing continuous aiding to the inertial sensors even during limited GPS satellite availability. To effectively exploit the capabilities of PF, advanced modeling for the stochastic drift of the vertically aligned gyroscope is used. In order to benefit from measurement updates for such drift, which are loosely-coupled updates, a hybrid loosely/tightly coupled solution is proposed. This solution is suitable for downtown environments because of the long natural outages or degradation of GPS. The performance of the proposed 3D Navigation solution using Mixture PF for 3D RISS/GPS integration is examined by road test trajectories in a land vehicle and compared to the KF counterpart.
Nuklearmedizin in Deutschland
Authors: Grgic A. , Kotzerke J. , Kirsch C.-M. , Hellwig D.
Published: April 2011

Aim: To explain the spectrum and number of in-vivo nuclear medicine examinations and therapies based on official statistics about out-patient and in-patient care. Trends in time of the frequency and spectrum of procedures as well as data on the health care structure for nuclear medicine in Germany should be collected. Methods: Data from the Gesundheitsberichterstattung des Bundes, from the frequency statistics of the statutory health insurance for out-patients and from the Bundes - ärztekammer were used. Customized queries were performed to analyse temporal changes. Results: Nuclear medicine physicians are more frequently consulted by out-patients over the last years (2008: 2 024 498; 2009: 2 164 664) and the number of colleagues in private practice increased. For in-patients, the frequency of conventional nuclear medicine procedures (mainly for brain, lymphatic system, lung and heart) increased since 2008 after a decline in previous years (2009: 323 515; +4.6%) and the number of PET(/CT) examinations continued to rise (2009: 25 123; +18%), even if changes in OPS keys may hamper comparisons. Nearly 600 gamma cameras and 76 PET(/CT) scanners were installed in hospitals in 2008. Nuclear medicine procedures are increasingly performed as cross sectional imaging like SPECT(/CT) and PET(/CT). With the supply shortfall with 99Mo, the frequency of thyroid scans with 123I iodine increased as well as the use of 18F PET as a substitute for conventional bone scans. The number of radionuclide therapies, in particular non-thyroid treatments, increased since the mid-nineties and stabilized at nearly 50 000 cases per year with shorter lengths of stay. Conclusion: The details of the present analysis may help to understand the positive evolution of key numbers for nuclear medicine.
Enseignements littéraires et œuvres de référence : entre l'ancien et le nouveau
Authors: Fraisse Emmanuel
Published: April 2011

Il existe une contradiction fondamentale et féconde entre l’esprit occidental, qui tend à valoriser le nouveau, et l’idée même d’enseignement, qui cherche à stabiliser et à transmettre. En France, cette tension entre ancien et nouveau se fait sentir avec une acuité toute particulière dans l’enseignement de la littérature. Au lycée notamment, cet enseignement a en effet pour objet explicite de définir, de conserver et de transmettre les œuvres établissant un ensemble de références partagées assurant aux individus la possibilité de se situer en tant que sujets et de vivre ensemble. L’étude des programmes des concours de recrutement des professeurs (et notamment l’agrégation) montre que si le passé est constamment l’objet d’une relecture par le présent, l’inscription d’œuvres nouvelles, dérangeantes par leur écriture et leur étrangeté même, ne se passe pas sans difficultés, débats et réticences. Tel est particulièrement le cas des œuvres francophones.
Neuropsychiatric Symptoms, Endophenotypes, and Syndromes in Late‐Onset Alzheimer′s Disease: Focus on APOE Gene
Authors: Panza Francesco , Seripa Davide , D′Onofrio Grazia , Frisardi Vincenza , Solfrizzi Vincenzo , Mecocci Patrizia , Pilotto Alberto
Published: April 2011

Neuropsychiatric symptoms, previously denominated as behavioural and psychological symptoms of dementia, are common features of Alzheimer′s disease (AD) and are one of the major risk factors for institutionalization. At present, the role of the apolipoprotein E (APOE) gene in the development of neuropsychiatric symptoms in AD patients is unclear. In this paper, we summarized the findings of the studies of neuropsychiatric symptoms and neuropsychiatric syndromes/endophenotypes in AD in relation to APOE genotypes, with special attention to the possible underlying mechanisms. While some studies failed to find a significant association between APOE and neuropsychiatric symptoms in late‐onset AD, other studies reported a significant association between the APOE ε4 allele and an increase in agitation/aggression, hallucinations, delusions, and late‐life depression or anxiety. Furthermore, some negative studies that focused on the distribution of APOE genotypes between AD patients with or without neuropsychiatric symptoms further emphasized the importance of subgrouping neuropsychiatric symptoms in distinct neuropsychiatric syndromes. Explanations for the variable findings in the existing studies included differences in patient populations, differences in the assessment of neuropsychiatric symptomatology, and possible lack of statistical power to detect associations in the negative studies.
Spontaneous Resolution of Obstructive Hydrocephalus from Blood in the Cerebral Aqueduct
Authors: Yaghi Shadi , Hinduja Archana
Published: April 2011

Obstructive hydrocephalus is a neurological emergency that needs to be immediately identified and treated. It very rarely resolves without treatment. We report about an 86-year-old man with right frontal stroke who developed obstructive hydrocephalus caused by blood in the cerebral aqueduct. The patient had sudden and immediate clinical improvement and a repeated head computed tomography (CT) scan showing spontaneous resolution of hydrocephalus. Spontaneous resolution of obstructive hydrocephalus is possible when the cause is minimal blood in the cerebral aqueduct without any blood in the fourth ventricle.
Prophylaxis and Therapy of Viral Infections in Pediatric Patients Treated for Malignancy
Authors: Licciardello Maria , Pegoraro Anna , Cesaro Simone
Published: April 2011

Infections are still an important cause of mortality and morbidity in pediatric cancer patients. Most of the febrile episodes in immunocompromised patients are classified as a fever of unknown origin (FUO) while bacteria are the more frequent causes of documented infections. Viral infections are also feared during chemotherapy but less data are available on their incidence and morbidity. We reviewed the literature on incidence, morbidity, and mortality of viral infections in children undergoing chemotherapy and discussed the evidence concerning the prophylaxis and the therapy.
SCS: Superior‐Vena‐Cava Compressing Shape‐Memory‐Alloy‐Based Implantable Device for Heart Failure
Authors: Kim Yongjin , Lee Jeonghyeon , Kim Jeongwon , Cho Domin , Lee Hyunwoo , Oh Se Jin , Han Amy Kyungwon
Published: February 2025

Heart failure (HF), particularly acute decompensated heart failure (ADHF), remains a significant health challenge, with limited long‐term therapeutic options to alleviate congestion and improve cardiac function. Pharmacological treatments focus on reducing congestion, but many patients are discharged with persistent symptoms, leading to poor outcomes. Current device‐based solutions, such as balloon catheters, offer some relief from fluid overload but require hospitalization, a driveline, and direct blood contact, limiting long‐term use. A superior‐vena‐cava (SVC) compressive shape‐memory‐alloy (SMA) implantable device, “SCS” is presented, which is designed to wrap around the SVC and externally compress it to regulate blood flow, alleviating ADHF symptoms. The SCS device, actuated by biocompatible SMA actuators, adjusts the SVC's cross‐sectional area to control blood flow. Unlike existing solutions, the SCS device operates without direct blood contact, minimizing thrombosis and endothelial damage while offering a long‐term implantable solution. Benchtop tests verified the SCS's effectiveness in flow regulation (68% decrease in flow rate) while maintaining a safe surface temperature (<40 °C). In‐vivo tests in a porcine heart failure model demonstrated the device's ability to reduce left ventricular preload, observed through a leftward shift in the pressure‐volume loop (18.6% reduction in end‐diastolic volume), validating its potential as a long‐term solution for ADHF.
First‐Principles Study on Introducing Fluorine Doping and Sulfur Vacancy into MoS2 for Advanced Lithium Storage
Authors: Xu Zhiling , Liao Yanbing , Lin Kaihui , Guan Jiayi , Lin Yuda , Qiu Liting
Published: February 2025

MoS2, a potential anode material for lithium ion batteries (LIBs), boasts high specific capacity, a unique layered structure, and large interlayer spacing, but struggles with poor conductivity and volume effect. Starting from improving the intrinsic electronic conductivity of MoS2, this study innovatively introduces F‐doping and sulfur vacancies into MoS2 crystals to form F‐MoS2‐x crystals, and investigates its structural features and LIBs applications through first‐principle calculations. The rationality and stability of F‐MoS2−x are calculated by phonon spectra. The density of states calculations reveals that F‐doping and sulfur vacancies effectively alter MoS2's electronic state, reducing its intrinsic band‐gap and confirming F‐MoS2‐x's superior electronic conductivity theoretically. They also significantly decrease lithium‐ion diffusion resistance on F‐MoS2‐x's surface, potentially enabling high‐rate performance. Besides, the calculation of adsorption energy and differential charge density reveals strong adsorption between F‐MoS2‐x and lithium ions, which favors long‐term cycle stability. Notably, with each F‐MoS2‐x molecule storing up to 4.5 Li, corresponding to a theoretical capacity of 769 mAh g−1, higher than MoS2's 670 mAh g−1. This study provides a meaningful reference value for the modification of MoS2.
A Mitochondria‐Targeted Biomimetic Nanomedicine Capable of Reversing Drug Resistance in Colorectal Cancer Through Mitochondrial Dysfunction
Authors: Wang Xiaohui , Xu Zhiyuan , Wang Jian , Wu Chunrong , Zhang Lin , Qian Chengyuan , Luo Yang , Gu Yanjuan , Wong Wing‐Tak , Xiang Debing
Published: February 2025

Chemoresistance and metastasis are the main obstacles to the clinical success of anticancer treatment and are responsible for most cancer deaths. Developing effective approaches to reverse chemoresistance and inhibit metastasis is essential for efficient chemotherapy. Mitochondria are important sources of cellular energy and are involved in mediating chemoresistance and driving tumor metastasis. Due to the relatively weak DNA repair capacity of mitochondria, targeting mitochondria may reverse chemoresistance and provide a paradigm for metastatic cancer treatment. Herein, exosomes (Exos) modified with integrin ligands and mitochondriotropic molecules are synthesized for encapsulating oxaliplatin (OXA) to construct a sequentially targeted and mitochondrion‐dysfunctional nanodrug (OXA@Exo‐RD). Subsequent investigations confirm that OXA@Exo‐RD targeted cancer cells and mitochondria in sequence, and OXA delivered to mitochondria lacking DNA repair mechanisms reduce the likelihood of deactivation. Furthermore, the OXA@Exo‐RD promotes the overproduction of ROS, inhibited ATP generation, and induces mitochondria‐mediated apoptosis and mitochondrial dysregulation. Finally, OXA@Exo‐RD shows the potential to inhibit the growth and metastasis of HCT116/OXA cells in vitro, which is further validated in subcutaneous and orthotopic CRC models, as well as in CRC metastasis models. Taken together, this dual‐targeting nanomedicine induces apoptosis via mitochondrial signaling pathways, providing an attractive strategy for the treatment of drug‐resistant CRC.
Synthetic High‐Throughput Microarrays of Peptidoglycan Fragments as a Novel Sero‐Diagnostic Tool for Patient Antibody Profiling
Authors: Tsouka Alexandra , Fu Yanyan , Ricardo Manuel G. , Seeberger Peter H. , Wang Yue , Pier Gerald B. , Schuppan Detlef , Boon Louis , Maarten van Dijl Jan , Bolling Maria C. , Buist Girbe , Loeffler Felix F , Laman Jon D.
Published: February 2025

Peptidoglycan (PGN) is a complex biopolymer crucial for cell wall integrity and function of all bacterial species. While the strong inflammatory properties of PGN and its derived muropeptides are well‐documented in human innate immune responses, adaptive immunity, including antibody responses to PGN, remain inadequately characterized. Microarray technology represents a cost‐ and time‐efficient method for studying such interactions. Our laser‐based technology enables the high‐throughput synthesis of biomolecules on functionalized glass slides. Here, this on‐chip synthesis was developed for PGN fragments, to generate a variety of 216 stem peptides and attach six different glycan moieties that are major structural components of bacterial cell walls. Thereby, 864 PGN fragments from different Gram‐negative and Gram‐positive species were generated. The arrays were validated with four different monoclonal antibodies against PGN or poly‐N‐acetyl glucosamine and identified their epitopes. Finally, proof of concept for antibody profiling in patient samples was performed by comparing a panel of well‐characterized plasma samples of epidermolysis bullosa (EB) patients suffering from (chronic) wounds with Staphylococcus aureus infection. EB patients show an increased response to the muramyl dipeptide. Therefore, this novel high‐throughput PGN glycopeptide microarray technology promises to identify distinct antibody profiles against human microbiomes in diseases, notably in those involving the intestine.
Copper in cancer: friend or foe? Metabolism, dysregulation, and therapeutic opportunities
Authors: Shan Dan , Song Jinling , Ren Yuqing , Zhang Yuyuan , Ba Yuhao , Luo Peng , Cheng Quan , Xu Hui , Weng Siyuan , Zuo Anning , Liu Shutong , Han Xinwei , Deng Jinhai , Liu Zaoqu
Published: February 2025

Copper, one of the essential nutrients for the human body, acts as an electron relay in multiple pathways due to its redox properties. Both deficiencies and excesses of copper lead to cellular fragility. Therefore, it can manifest pro‐ and anti‐cancer properties in tumors. Therefore, it is crucial to clarify the copper activity within the cell. We have thoughtfully summarized the metabolic activities of copper from a macro and micro perspective. Cuproptosis, as well as other forms of cell death, is directly or indirectly interfered with by Cu2+, causing cancer cell death. Meanwhile, we did pan‐cancer analysis of cuproptosis‐related genes to further clarify the roles of these genes. In addition, copper has been found to be involved in multiple pathways within the metastasis of cancer cells. Given the complexity of copper's role, we are compelled to ask: is copper a friend or a foe? Up to now, copper has been used in various clinical applications, including protocols for measurement of copper concentration and bioimaging of radioactive 64Cu. But therapeutically it is still a continuation of the old medicine, and new possibilities need to be explored, such as the use of nanomaterials. Some studies have also shown that copper has considerable interventional power in metabolic cancers, which provides the great applications potential of copper therapy in specific cancer types. This paper reviews the dual roles played by cuproptosis in cancer from the new perspectives of oxidative stress, cell death, and tumor metastasis, and points out the value of its application in specific cancer types, summarizes the value of its testing and imaging from the perspective of clinical application as well as the current feasible options for the new use of the old drugs, and emphasizes the prospects for the application of nano‐copper.
Organo‐, Metal‐ and Enzyme Mediated Stereoselective Transformations of a‐Angelica Lactone
Authors: Lattanzi Alessandra , Meninno Sara , Moutayakine Amina
Published: February 2025

alpha‐Angelica lactone is a five‐membered heterocycle belonging to the rich family of butenolides, key motif present in a great variety of bioactive and natural products. Moreover, it is a small compound attainable from platform molecule levulinic acid, which in turn is readily accessible from lignocellulosic biomass. These important features contributed to arouse interest in a‐angelica lactone over the last years. Beyond its upgrading to added value products, such as g‐valerolactone, polymers, biofuels, a‐angelica lactone has been identified as a building‐block in natural product synthesis and a useful reagent in asymmetric catalysis. In this minireview, we provide an overview of diastereo‐ and enantioselective organo‐, metal‐, and enzymatic approaches reported from 2020 up to 2024, where this heterocycle has been used as the starting material. a‐Angelica lactone proved to be a versatile scaffold in stereoselective vinylogous 1,4‐ and 1,2‐addition, cycloaddition, isomerization, g‐arylation and reduction reactions.
Experiential Reflecting Teams in the Training of Group Counselors
Authors: Henry Melissa C. , Woo Hongryun , Zoernig Emily L. , Schmidt Noah C. , Campbell Brennen , Bozarth Whitney
Published: February 2025

Using a comparative case study design, this study explored the reflecting team (RT) method in group training among counseling students (n = 26). Participants were assigned to either the experiential group (EG) or RT, and group climate was assessed using the Group Climate Questionnaire (GCQ‐S). Results indicated that RT members reported higher avoidance, but similar levels of engagement and conflict compared to EG members. Rooted in social constructivist theory, the study explored experiential instruction in group training.