bluuebunny/crossref_metadata_2025 huggingface dataset:
Antimicrobial resistance trends among Klebsiella pneumoniae associated with urinary tract infections in Crete, Greece, 2017–2022
Authors: Maraki Sofia , Mavromanolaki Viktoria Eirini , Stafylaki Dimitra , Iliaki-Giannakoudaki Evangelia , Kasimati Anna
Published: May 2024

Klebsiella pneumoniae is one of the most prevalent bacteria causing urinary tract infections (UTIs). Its increasing resistance to a wide array of antibiotics limits available treatment options. This study investigated the characteristics and trends of antimicrobial resistance in K. pneumoniae isolated from UTIs in Crete, Greece, during 2017 and 2022. Among the 11,946 Enterobacteriaceae isolated from urine specimens, a total of 1,771 K. pneumoniae isolates were identified (14.8%), with an isolation frequency secondary to Escherichia coli (66.3%). K. pneumoniae isolates increased over the years, with a peak in the year 2022. Higher resistance rates were detected in ciprofloxacin (41%), trimethoprim/sulfamethoxazole (TMP/SMX) (38.1%) and nitrofurantoin (33.9%). Resistance to ciprofloxacin, amoxicillin/clavulanic acid, tigecycline, and TMP/SMX significantly increased from 33.7%, 24%, 6%, and 33.1%, respectively, over the years 2017–2019, to 47.8%, 34.2%, 14.3% and 42.8%, respectively, over the period 2020–2022. ESBL production and carbapenem resistance were decreased by 2.2% and 3.7%, respectively, over the two three-year periods (2017–2019 and 2020–2022). Among the 278 carbapenem-resistant K. pneumoniae (CRKP) isolates, 164 (59%), 66 (23.7%), 18 (6.5%) and 16 (5.8%) were positive for KPC, NDM, VIM and OXA-48 enzymes, respectively. Only 14 (5%) isolates harboured two carbapenemase genes, namely 10 (3.6%) both blaNDM and blaVIM, and 4 (1.4%) both blaKPC and blaNDM. Females, inpatients and the elderly were more frequently affected by CRKP. The frequency of multidrug-resistant (MDR) and extensively drug-resistant (XDR) isolates were 32.6% and 7.7%, respectively. Continuous surveillance of local microbial prevalence and monitoring of antimicrobial resistance patterns provide critical information to guide the empiric therapy for UTIs and control the spread of MDR bacteria.
Antioxidant, α-amylase, and α-glucosidase inhibitory activities of onion (Allium cepa) and shallot (Allium oscalonicum L.) in food ingredients
Authors: Vichaibun V. , Sophonnithiprasert T.
Published: May 2024

Both onion and shallot are the most common ingredients to use for many recipes. Consuming onion and shallot provide health benefits including antidiabetic effects. However, the benefits of onion and shallot mixture at different ratios have not been studied in terms of total phenolic content, total antioxidant capacity, superoxide dismutase (SOD)-like activity, and antidiabetic effects. Our study revealed that shallot significantly increased total phenolic content in the mixture from 492 ± 32 μg mL−1 (100% v/v onion) to 803 ± 24 μg mL−1 (100% v/v shallot) depending on the ratios of shallot in the mixture. Shallot also significantly enhanced total antioxidant capacity, SOD-like activity, α-amylase inhibition, and α-glucosidase inhibition in the mixture. Shallot juice exhibited the highest percentage inhibition of α-amylase activity (40.51 ± 1.57%) and α-glucosidase activity (89.61 ± 2.85%) in comparison to those of onion juice and the mixture. In addition, significant positive correlation between phenolic compound and different variables was observed (P < 0.05). Phenolic compounds present in onion and shallot are probably responsible for many health benefits including antidiabetic effects.
Native Kidney Renal Cell Carcinoma in Renal Allograft Transplant Patients – Our Experience
Authors: Survase Pavan , Agrawal Shashank , Singh Abhishek , Sabnes Ravindra , Desai Mahesh
Published: May 2024

The immunosuppression administered to renal transplant recipients to safeguard renal function elevates their susceptibility to renal cancer, which is estimated to be 15 times higher than in the general population. The current study aimed to analyze various aspects of native kidney renal cell carcinoma (RCC) in renal transplant recipients. This study involved a retrospective analysis of 11 patients who underwent nephrectomy for RCC in native kidneys among renal transplant recipients at our institution since 1992. Our institutional incidence was 0.4%. Median age at presentation was 57 (49–60) years. The ratio of male: female was 10:1. Most patients were asymptomatic at presentation and native kidney disease before transplantation was undetermined. In our study, the median time interval between diagnosis of RCC and transplant was 9.1 (8.4–11.2) years. All patients underwent native kidney nephrectomy. Clear cell type was more common than papillary type, 3.5 (2.5–4.2). Ten patients were diagnosed with stage I disease and one patient had stage IV disease. Fuhrman nuclear grading revealed low grades in nine patients and three patients had Grade 3. Immunosuppressive therapy modification was done in nine patients. Meticulous follow-up of renal transplant patients is essential for earlier diagnosis and appropriate treatment of native kidney RCC in transplant recipients. Authors recommend every year follow-up in transplant recipients with special emphasis on ultrasound of native kidney.
Application of chemometrics in customs expertise
Authors:   Federal Research Center for Chemical Physics of the Russian Academy of Sciences (FITC HF RAS), Pomerantsev A. L. , Rodionova O. E. ,   Federal Research Center for Chemical Physics of the Russian Academy of Sciences (FITC HF RAS)
Published: May 2024

The short communication provides information about the papers published in this issue of the journal by the experts of customs services of the Russian Federation, which resulted from their successful completion of the course in chemometrics conducted by the authors of the communication.
Application of infrared spectroscopy in combination with chemometric algorithms for determining the presence of styrene-butadiene block copolymer in bitumen products
Authors:   Expert-Criminalistic Service – Regional Branch of the Central Expert-Criminalistic Customs Administration of Saint Petersburg, Ogorodnikova E. S.
Published: May 2024

At present polymer-bitumen binders (PBB), including those containing styrene-butadiene copolymer (SBC), are widely used for improving the performance of asphalt concrete coverings. Qualitative detection of the polymer in the petroleum bitumen composition is a difficult research task owing to the low content of the polymer in the PBB composition. Existing methods for determining the polymer in petroleum bitumen are based on a complex multi-stage extraction or on measuring the specific characteristic viscosity of the polymer in the analyzed PBB. These methods are time-consuming and labor-intensive, and require application of a number of specific organic solvents and reference standards. The present work considers the possibility of applying infrared spectroscopy of disturbed total internal reflection (ATR) with subsequent processing of spectra using chemometric algorithms in the study of PBB containing SBC. Application of the principal component analysis (PCA), as well as one-class classification method, the method of soft independent modeling of class analogy (DD-SIMCA), is illustrated. The use of infrared spectroscopy in combination with chemometric data processing methods greatly simplifies and accelerates the research task of detection SBS in bitumen products. The objective of this work was to solve the classification and identification problem in the course of studying bitumen products, i.e. attributing/non-attributing a bitumen product to PBB with SBS.
Chemometric method in spectrometric analysis of biodiesel for customs purposes
Authors:   Rostov-on-Don Regional Branch of Central Expert-Criminalistics Customs Administration, Berezov P. N. , Goleva V. E. ,   Rostov-on-Don Regional Branch of Central Expert-Criminalistics Customs Administration
Published: May 2024

The article is devoted to developing a rapid control method of transported goods declaration authenticity. Currently there is increasing share of biofuels on international market and in export-import operations. Customs control of fuels gives a particular attention to correct verification of the declared code in accordance with the Commodity Nomenclature of Foreign Economic Activity of the Eurasian Economic Union (hereinafter referred to as the CN of the EAEEU). Biodiesel-containing fuels have peculiarities of classification in accordance with the CN of the EAEEU due to specific chemical composition. The standard method of determination of biodiesel fuels’ composition, according to GOST 33077-2014, using spectroscopy in the mid-infrared region has a limited measurements range for the customs purposes, does not allow preliminary verification of authenticity of goods’ declaration, and requires delivery of samples to the laboratory. A method for rapid determination of a group of petroleum fuels by combining infrared spectrometry and chemometrics methods was developed. Spectral data of petroleum fuels containing and not containing biodiesel were analyzed, and calibration models were constructed using the method of projection on the latent structures (PLS-DA). The model of discriminatory analysis using the regression on latent structures allowed to separate quite clearly fuels belonging to different classes or goods’ types according to the CN of the EAEEU. Attributing a fuel sample spectrum to a separate class indicates that the fuel belongs to a group similar to other samples of this class. The problem of classification in the fuel analysis was solved using the chemometric method. The proposed method will provide rapid verification of authenticity of the fuel declaration during customs inspection of goods.
Chemometric interpretation of the results of chromato-mass spectrometry analysis of mineral and synthetic oils for customs purposes
Authors:   Expert-Criminalistics Service – Regional Branch of the Central Expert-Criminalistics Customs Administration, Lyakaev D. V. , Pastukhov M. O. ,   Central Expert-Criminalistics Customs Administration
Published: May 2024

Application of the principal component method (PCA) using the example of distinguishing mineral, synthetic and semi-synthetic motor oils from the results of chromatography-mass spectrometric analysis is considered in the present work. Samples of commercial oils of domestic and foreign production constituted the objects investigated. A generalized algorithm for constructing a classification model, including the stages of preliminary processing of spectral information, as well as conditions for setting up the experiment, is proposed. The principal component analysis (PCA) and the principal component regression (PCR) methods were applied to evaluate the results obtained. Chromatograms of the studied samples acted as the primary data for chemometric processing. Analysis of the graphs of scores in the model constructed by PCA for the first and second principal components revealed that the points corresponding to different groups of objects did not overlap and were located in different areas in relation to the first and second principal components. The loadings plot reflects the characteristic retention times, which are responsible for separating studied samples into mineral and synthetic oils. The PCR method was chosen for modeling chromatography-mass spectrometry data taking into account the task of quantitative identification of mixed compositions of mineral and synthetic oils. Based on the results obtained it was found that chromatography-mass spectrometry in combination with chemometric methods of analyzing multifactorial dependencies can be applied for solving problems, related to determining qualitative and quantitative composition of motor oils. The obtained models demonstrate sufficient accuracy for qualitative and quantitative determination of the composition of mixed motor oils based on mineral and synthetic base components.
Linking Basement Membrane and Slit Diaphragm in Drosophila Nephrocytes
Authors: Leroy Claire , Lang Konrad , Spitz Dominik , Milosavljevic Julian , Heinkele Helena , Kayser Séverine , Helmstädter Martin , Walz Gerd , Ulbrich Maximilian H. , Hermle Tobias
Published: May 2024

Key Points

Drosophila nephrocytes feature a special basement membrane that may serve to model joint function of the glomerular filtration barrier.

Silencing of Drosophila laminin and collagen IV genes reduced the density of slit diaphragms in nephrocytes, showing a direct effect of the matrix.

Matrix receptor silencing phenocopied basement membrane disruption, indicating that the matrix guides slit diaphragm position through matrix receptors.

Background

The glomerular basement membrane and the slit diaphragm are essential parts of the filtration barrier. How these layers collaborate remains unclear. The podocyte-like nephrocytes in Drosophila harbor both a slit diaphragm and a basement membrane, serving as a model to address this critical question.

Methods

Basement membrane components and matrix receptors were silenced using RNA interference in nephrocytes. Slit diaphragms were analyzed using immunofluorescence, followed by automated quantification. Tracer endocytosis was applied for functional readouts.

Results

Immunofluorescence indicated a significant reduction in slit diaphragm density upon loss of laminin and collagen IV components. This was accompanied by reduced expression of fly nephrin and shallower membrane invaginations. Tracer studies revealed that the basement membrane defines properties of the nephrocyte filtration barrier. Acute enzymatic disruption of the basement membrane via collagenase rapidly caused slit diaphragm mislocalization and disintegration, which was independent of cell death. Loss of matrix-interacting receptors, particularly integrins mys and mew, phenocopied basement membrane disruption. Integrins and nephrin colocalized at the slit diaphragm in nephrocytes in a mutually dependent manner, interacting genetically. Human integrin α3 interacted physically with nephrin.

Conclusions

The glomerular basement membrane model in Drosophila nephrocytes reveals that matrix receptor–mediated cues ensure correct positioning of the slit diaphragm and the overall filtration barrier architecture.
A complexidade dos direitos sociais na clínica em psicologia: fatores materiais, singulares e multidimensionais
Authors:   Secretaria  Municipal  de  Saúde de Florianópolis, Dall’Igna Ecker Daniel , de Lima Palombini Analice ,   Universidade  Federal  do  Rio  Grande  do  Sul
Published: May 2024

Objetivo:o artigo deriva da pesquisa de doutorado que teve como objetivo analisar como o exercício de dire-itos sociais incide nos processos subjetivos e terapêuticos em curso na clínica em psicologia articulada às políticas públicas brasileiras. Metodologia: subsidiado por registros de experiências — 28 casos clínicos em acompanhamento terapêuti-co, documentos institucionais, registros em diário de campo, imagens, entre outros —, focaliza a discussão sobre a complexidade dos direitos sociais na clínica em psicologia. Por meio da epistemologia e do método inspirado no pós-estruturalismo, mapeia o modo como o discurso dos direitos sociais — educação, saúde, alimentação, trabalho, moradia, transporte, lazer, segurança, previdência social, proteção à maternidade e à infância e assistência aos desamparados — emerge nos materiais e fornece elementos para pensar como os sujeitos produzem e conduzem a si na vida e nos processos terapêuticos como seres subjetivos. Resultados:nos resultados, em interlocução com autores(as) da área, o artigo propõe três centros de análise integrados: (1) fatores materiais; (2) fatores singulares; (3) multidimensionalidade. Conclusões: esses centros consideram a complexidade da articulação entre vida, Estado, políticas públicas, processos terapêuticos e subjetivos.
Funciones psicosociales y consecuencias del chisme en las organizaciones: el caso de un grupo de trabajadores del área de mercadeo en una empresa de servicios
Authors:   Universidad EAFIT, Moreno Cabezas Sandra Catalina , Vásquez Ochoa Andrés Miguel ,   Universidad EAFIT, Gañán Moreno Anderson ,   Universidad EAFIT, Orejuela Gómez Johnny Javier ,   Universidad EAFIT
Published: May 2024

Objetivo:Se identificaron las funciones psicosociales y consecuencias positivas y negativas del chisme, dentro de un grupo de trabajadores de mercadeo de una empresa de servicios de Medellín, Colombia. Método: Fue un estudio cualitativo de enfoque descriptivo desarrollado a manera de estudio de caso basado en entrevistas semiestructuradas a 7 empleados. Se encontró que el chisme tiene la función psicosocial de permitir la transmisión de información, el fortalecimiento del lazo de amistad y entretenimiento. Resultados: El principal facilitador del chisme es la incertidumbre; el principal obstáculo la censura; lo positivo del chisme es que facilita la transmisión de la cultura organizacional y paradójicamente puede ser un facili-tador en la resolución de conflictos, así como un generador de conflictos, malentendidos y malestar. Como conclusión, el chisme funciona como un mecanismo efectivo para el intercambio de información con contenido evaluativo acerca de terceros ausentes en un contexto de confianza, que además permite la liberación de estados emocionales, lo cual impide la expresión directa de la violencia en las organizaciones.
Mirada bioética a la eutanasia en Colombia: Lecturas desde los actores involucrados en el proceso
Authors:   Universidad Católica Luis Amigó, González-Cortés Jorge Hernán , Valencia-Cano Laura María , Arias-Castrillón Yesika Fernanda , Castaño-Londoño Mariana
Published: May 2024

Objetivo: Describir convergencias y divergencias entre las percepciones de pacientes con enfermedades terminales, crónicas o degenerativas, familiares y personal sanitario de Manizales respecto a la aplicación e implicaciones de la eutanasia.Metodología: Investigación mixta, con diseño de triangulación concurrente y con una muestra conformada por 45 participantes seleccionados mediante muestreo por cuotas.Resultados: Pacientes, familiares y profesionales sanitarios convergen en afirmar que la autonomía es el principio bioético que orienta la aplicación de la eutanasia, a pesar que los profesionales privilegian mayor conocimiento del principio de justicia; al mismo tiempo que se concluye conocimiento limitado frente las leyes y sentencias que rigen la eutanasia en Colombia.Valor del estudio: El estudio representa utilidad tanto para los participantes en la medida que permite identificar la incidencia de las creencias sociales y familiares en la aplicación de la eutanasia, como para las instituciones hospitalarias al permitirles informarse acerca de los motivos que hacen que el personal sanitario participe en el proceso y el nivel de afectación al que están expuestos.Conclusión: Persisten indicadores de desconocimiento por parte del personal sanitario, familiares y pacientes con enfermedades crónicas, terminales o degenerativas respecto a los protocolos de atención para la eutana-sia, evidenciando la necesidad de cualificar los procesos de formación ética al personal asistencial. Mientras tanto, el debate frente al procedimiento está permeado por las cuestiones respecto a los derechos humanos, la dignidad y la calidad de vida del enfermo y sus familiares.
Riesgos psicosociales como predictores del consumo de drogas en estudiantes universitarios mexicanos de Ciencias de la Salud
Authors:   Universidad Veracruzana, Beverido Sustaeta Paulina , Salas García Betzaida ,   Universidad Veracruzana, Gogeascoechea María del Carmen ,   Universidad Veracruzana, De San Jorge Cárdenas Xóchitl
Published: May 2024

Introducción: Resulta relevante conocer cómo se comportan los estudiantes de Ciencias de la Salud, en cuanto al consumo de drogas psicoactivas, debido al impacto que este comportamiento puede tener en su futuro desempeño profesional. Objetivo: conocer si los factores de riesgo psicosociales (intención de consumo, uso del tiempo libre, síntomas de ansiedad y depresión) son predictores (OR) del consumo de drogas legales, ilegales y fármacos sin pres-cripción. Método: estudio ex post facto, epidemiológico y transversal realizado a través de un sondeo en línea en el que participaron 5,881 estudiantes —con una edad promedio de 21 años (DE=2,72)— de las carreras del área de Ciencias de la Salud de una universidad pública mexicana, de manera voluntaria y anónima. Resultados: los estudiantes de Psicología presentaron las prevalencias de consumo más altas y los de Enfermería las más bajas en todas las drogas a excepción de la cocaína. Se encontró que los de Psicología tienen mayor posibilidad de consumir marihuana que el resto de las carreras del área de Ciencias de la Salud, mientras que los de Nutrición presentaron mayor posibilidad de consumo de cocaína. Conclusiones: los síntomas de ansiedad fueron predictores del consumo de todas las drogas legales e ilegales; los síntomas de depresión fueron predictores del consumo de tabaco, alcohol y fármacos sin prescripción y la intención conductual de consumo fue el predictor del consumo de tabaco, alcohol, fármacos sin prescripción, marihuana y cocaína. Es importante continuar realizando investigaciones que confirmen estos hallazgos en otras poblaciones universitarias con el fin de respaldar intervenciones efectivas en este tipo de poblaciones.
Relación entre los dominios de la inteligencia emocional con las habilidades sociales en estudiantes universitarios
Authors:   Corporación Universitaria Minuto de Dios, Sánchez-Ceballos Leidy Alejandra , Trujillo Galeano Ángela ,   Corporación Universitaria Minuto de Dios, Ramírez Garzón Yildry Paola ,   Corporación Universitaria Minuto de Dios, Londoño Correa Wendy Yuliana ,   Corporación Universitaria Minuto de Dios, Sánchez Barrientos Daniel ,   Corporación Universitaria Minuto de Dios
Published: May 2024

La presente investigación tiene como objetivo relacionar los dominios de la inteligencia emocional y las habi-lidades sociales en estudiantes universitarios. Método: investigación de tipo no experimental, comparativo/correlacional. Se evaluaron un total de 314 es-tudiantes de educación superior de un programa de psicología de la cuidad de Bello, Antioquia. Para la reco-lección de datos, se aplicaron el cuestionario de habilidades sociales CHASO III y la escala de metacognición emocional TMMS-24 para inteligencia emocional. Resultados: se identificó que existe una correlación positiva significativa entre los dominios de inteligencia emocional y habilidades sociales. Así como, una diferencia estadísticamente significativa a favor del grupo hombres en algunos aspectos de las habilidades sociales y, por grupo edades, sobresalen los participantes mayores de 26 años en algunos elementos de inteligencia emocional y habilidades sociales. Por último, los factores pedir disculpas y expresar sentimientos positivos de habilidades sociales presentan mayor fuerza de asociación con las competencias emocionales.
Prevalencia de los motivos de consulta en el Centro Integral de Psicología de una Universidad colombiana
Authors:   Corporación Universitaria Empresarial Alexander von Humboldt Colombia, Berrío-García Nathaly , Zedán-Salinas Karina Paola , Benavides-Ponce Magda Fernanda , Giraldo-Giraldo Angélica Johana
Published: May 2024

La salud mental es un estado dinámico, expresado en el diario vivir a través del comportamiento y la interac-ción de un individuo y los grupos, en el que se despliegan los recursos emocionales, cognitivos y mentales disponibles para vivir, trabajar, relacionarse y contribuir a la sociedad. El objetivo principal de este estudio fue estimar las prevalencias de los motivos de consulta de la población del departamento del Quindío y el norte del departamento del Valle del Cauca, que asistió al centro de atención psicológica de una institución de educación superior colombiana entre 2020 y 2022. La muestra estuvo constituida por 404 consultantes que aceptaron participar del estudio mediante el consentimiento informado. Por género, los motivos de consulta más prevalentes fueron los problemas emocionales en las mujeres (22,4 %) y los problemas escolares en los hombres (22,4 %). El principal motivo de consulta en los niños son los problemas escolares (37 %) y en los adolescentes son los problemas emocionales (25,5 %). En la adultez, los motivos de consulta más comunes son los problemas de la relación conyugal (entre 6 % y 23,7 %) y el duelo (23,5 %). Los hallazgos sugieren la necesidad de planificar estudios regionales de prevalencia y de realizar una juiciosa revisión de las políticas en salud pública, para incluir otros problemas que pueden ser objeto de atención clínica como de intervención prioritaria.
Evaluación de la calidad interna, externa y vida útil del huevo comercial en condiciones de trópico
Authors:   Universidad Cooperativa de Colombia, Guerrero Díaz Sandra Milena , Sanabria Naranjo Fernando ,   Avícola SINAIN S.A.S., Sánchez Guerrero Julián Andrés ,   Avícola SINAIN S.A.S., Castellanos Flórez Carmen Janeth ,   Avícola SINAIN S.A.S., Gamboa González Nidia Fernanda ,   Universidad Cooperativa de Colombia
Published: May 2024

Los parámetros de calidad interna y externa del huevo son indicadores del estado de frescura que este presenta. Se evaluó el efecto del tiempo en la calidad del huevo comercial almacenado en anaquel. Se utilizaron 120 huevos provenientes de la línea genética Isa Brown y HyN Brown Nick divididos en dos grupos (grupo A y grupo B). Las variables fueron medidas cada tres días hasta el día 28 de edad del huevo. Se analizó el peso, unidades haugh, pigmentación de yema, grosor de la cascara, índice de yema, pH de albumina y yema e inspección visual. Se observaron diferencias significativas en (p>0.05) en la mayoría de las variables analizadas durante el tiempo de estudio. Ambos grupos presentaron una disminución en el peso del huevo (-3.1 gr grupo A y 3.8 gr grupo B), uni-dades haugh (-26.2 gr grupo A y -34.7 gr grupo B), índice de yema (-0,34%grupo A y -0,36 % grupo B),inspección visual ( -6 puntos grupo A y 3.7 puntos grupo B), pigmentación yema (- 2.1 grupo A y -1.4 grupo B) y pH albumina (-1 grupo A y -0,5 grupo B ); después de 28 días de almacenamiento. En cuanto al pH de la yema no presentó diferencias significativas (p>0.05), los valores se mantuvieron durante el estudio. El ambiente influyó en los pará-metros de calidad del huevo, reduciendo su nivel de frescura, exceptuando el Ph de yema, el cual tuvo un proceso de degradación menor.
Integrated laser ablation and droplet collection system for efficient single cell isolation v1
Authors: Chen Liang , V. Liyu Andrey , Kwon Yumi , Zhu Ying , not provided Ljiljana.PasaTolic
Published: May 2024

State-of-the-art omics and imaging technologies for transcriptome, epigenome, and proteome measurements at the single-cell level have been successfully demonstrated and integrated into large tissue mapping consortia (e.g., HuBMAP, SenNet). However, current approaches for probing spatial distribution of the proteome typically rely on the use of antibodies, which limits multiplexing and requires a priori knowledge of protein targets. In this protocol, we describe a novel MS based spatial proteomic approach and deploy it for unbiased and deep mapping of proteins in tissues and specifically within senescent cells and their surrounding tissue microenvironment. The spatial single-cell proteomics (SSCP) technology enables efficient sample collection at high spatial resolution (5-10 μm) and opens the door to global cellular, subcellular and organelle proteomics. This approach is demonstrated here applied to a mouse tissue sample.
Reliability approach for lifetime prediction of the aluminum extrusion dies
Authors:   Department of Mechanical Engineering, Badji Mokhtar-Annaba University, Hadji Mustapha , Benamira Mohamed ,   Department of Mechanical Engineering, Badji Mokhtar-Annaba University, Khelif Rabia ,   Department of Mechanical Engineering, Badji Mokhtar-Annaba University
Published: May 2024

This paper introduces a probabilistic approach for predicting the lifetime of extrusion dies using a structural reliability method known as stress-strength interference. In our investigation, we have integrated the assessment of the die's cycle life by following behavioral and rheological law. The approach relies on estimating the reliability index through a combination of a behavioral model and a reliability analysis of the hot extrusion process. Subsequently, the reliability analysis is conducted using a mechanical model to depict the most likely failure conditions. In this regard, the rheological law of Hansel & Spittel emerges as the most suitable choice, as it incorporates the mechanical properties of the materials employed in the fabrication of hot tools. The proposed mechano-reliability approach enables us to estimate reliability and its sensitivity by adjusting the parameters controlling the input process in die formation. Numerous scenarios involving extrusion dies were considered. The results demonstrate that temperature's impact on the die during the extrusion process is manifested through fatigue and damage parameters, as well as the first equivalent strain, which affect the evolution of the reliability index β and subsequently enhance the number of billets extruded.
Filament manufacturing via external grooving of an HDPE pipe wall: RSM optimization and mechanical tests validation
Authors:   Mechanics of Materials and Plant Maintenance Research Laboratory (LR3MI), Mechanical Eng. Dept., Faculty of Technology, Badji Mokhtar University, Mammeri Sabrina , Bouacha Khaider ,   Faculty of Sciences and Technology, Mohamed-Chérif Messaadia University, Chaoui Kamel ,   Mechanics of Materials and Plant Maintenance Research Laboratory (LR3MI), Mechanical Eng. Dept., Faculty of Technology, Badji Mokhtar University, Ghabeche Wafia ,   Mechanics of Materials and Plant Maintenance Research Laboratory (LR3MI), Mechanical Eng. Dept.,  LR3MI, Elect. Eng. Dept., Faculty of Technology, A. Mira University of Bejaia, Berkas Khaoula ,   Mechanics of Materials and Plant Maintenance Research Laboratory (LR3MI), Mechanical Eng. Dept., Faculty of Technology, Badji Mokhtar University
Published: May 2024

In order to explore the possibilities of manufacturing and testing specimens from extruded HDPE pipes to retrace material inherent properties, continuous filaments are circumferentially machined by grooving. The proposed protocol imposes to keep to a strict minimum damage effects since semi-crystalline polyethylene is sensitive to deformation and heat. A Taguchi plan is adopted with inputs (cutting speed; feed rate; depth of cut). The modeled performance characteristics are roughness criteria (Rt; Ra) and temperature (T°). Using ANOVA and response surface methodology, the optimized values are 137.0 m/min, 0.4 mm/rev and 4.0 mm respectively for Vc, f and ap. At the highest desirability, the values of Rt (1.100 μm), Ra (0.223 μm) and T (36.44 °C) are satisfactory compared to turning data. Tensile tests on specimens from outer, middle and inner pipe show that (σ–ε) curves are reproducible with a pronounced drawing zone, especially for the inner pipe layers. Practically, the elasticity modulus is increased by 43% from outer to inner layers while the utmost difference in the elastic limit is ~ 5%. Concerning failure strain, the increase is 47% meaning that the material shows a great predisposition to ductility. This behavior is related to the higher crystallinity in internal pipe layers.
Development of eco-friendly self-compacting concrete using marble powder, blast furnace slag and glass fibre-reinforced plastic waste: Application of mixture design approach
Authors:   LTPiTE Laboratory, Ecole Nationale Supérieure des Travaux Publics-Francis Jeanson, Djeddou Manel , Amieur Mohamed ,   LTPiTE Laboratory, Ecole Nationale Supérieure des Travaux Publics-Francis Jeanson, Chaid Rabah ,   Research Unit: Materials, Processes and Environment, M'hamed Bougarra University of Boumerdes, Mesbah Habib-Abdelhak ,   INSA de Rennes, Université de Rennes 1, L.G.C.G.M. Laboratory, Rennes, France
Published: May 2024

The present paper investigates the valorisation of three local Algerian waste materials, namely Marble Powder (MP), Ground Granulated Blast Furnace Slag (GGBS), and Glass Fibre-Reinforced Plastic Waste (GFRPW), as mineral additions in Self-Compacting Concrete (SCC). A mixture design modeling approach was used to evaluate the impact of these waste materials and their interactions on the fresh and hardened properties of SCC. Experimental tests were performed, including slump flow, V-funnel, L-box, air content, and compressive strength tests. Regression models were developed to understand the behaviour of SCC based on the proportions of MP, GGBS, and GFRPW in both binary and ternary systems. The statistical analysis software Minitab was employed for the modeling. The results revealed that the combination of MP, GGBS and GFRPW in ternary systems has a synergistic effect on slump flow and L-box ratio. The highest slump flow value and L-box ratio were achieved at proportions of approximately 38% MP, 37% GGBS, and 25% GFRPW. The V-funnel time was affected by the proportions of the waste materials, decreasing with higher MP and GFRPW proportions and increasing with a higher GGBS proportion. In GFRPW-based systems, a higher GFRPW proportion increased the air content, but combining GFRPW with GGBS significantly reduced it. Furthermore, the interaction between GGBS and GFRPW enhanced the development of the 28-day compressive strength, where the highest value of 54 MPa was reached at the combination of 32% GFRPW and 68% GGBS. After 90 days of curing, the SCC mixtures containing 100% GGBS exhibited the highest compressive strength value of 66 MPa. This study provides valuable insights for optimising the use of MP, GGBS, and GFRPW in SCC, potentially leading to more sustainable and cost-effective concrete production.
Prototype silicone rubber based passive seismic damper: Development, characterization and implementation
Authors:   Dept. of Civil Eng., School of Engineering, Institute of Technology, Nirma University, Koshti Utsav , Purohit Sharadkumar ,   Dept. of Civil Eng., School of Engineering, Institute of Technology, Nirma University
Published: May 2024

Passive damping devices are mostly preferred owing to their relatively lower cost, low maintenance, and stability over a wide range of frequencies during seismic events. Currently, these devices with temperature in-sensitive viscoelastic material are being explored. The paper aims to develop a prototype piston-cylinder based passive damper with silicone rubber particles and characterize it with varied amplitude and frequency of sinusoidal input. The device Silicone Rubber Particle Packed Damper, so developed, was then implemented in the benchmark building for seismic response control. Silicone rubber particles with lower hardness were produced through compressed molding technology to improve the damping efficiency of the device. The device was later converted to an Air Damping Device by removing silicone rubber particles for a natural comparison of efficacy. Hysteresis curves of devices, elliptical in shape, obtained through characterization were mathematically modelled using the Kelvin-Voigt model, and parameters were identified using multivariable linear regression to implement them with the benchmark building. Uncontrolled and controlled responses of benchmark building fitted with, both, damping devices were determined under strong motion (El Centro, Hachinohe) and pulse-type (Kobe, Northridge) seismic excitations. Seismic response parameters; peak displacement, peak interstorey drift, peak acceleration, and peak damper force was estimated. Each seismic response parameter yields substantial reduction for controlled benchmark building with Silicone Rubber Particle Packed Damper. The efficacy of damping devices was established by Performance Indices in terms of peak interstorey ratio, level acceleration, base shear, and control force. Though both passive damping devices were found effective in seismic response control of benchmark building, Silicone Rubber Particle Packed Damper outperforms Air Damping Device. The developed prototype damping devices are a low cost and easy to maintain.
The School bus routing problem: A systematic literature review
Authors:   Tecnológico de Monterrey, Díaz-Ramírez Jenny , Rosas Angela María ,   Universidad de Monterrey, García-Colis Bárbara ,   Universidad de Monterrey, Valencia-Torres Paula Sofía ,   Universidad de Monterrey
Published: May 2024

The School Bus Routing Problem (SBRP) is a classic optimization problem with a massive potential for real applications that have a high impact on society. Research interest in this problem is constantly rising. Previous review papers with a time-space between them of 10 years have helped understand the different features studied by the research community about this problem. In this systematic review, we consider two new categories not discussed before: the incorporation of a mixed load composed of multiple schools, along with the inclusion of a smart element related to the availability of user information and communication in real-time to join the smart mobility trend. In addition, we discuss the lack of real applications in the SBRP in university contexts with a focus on the multi-load problems.
Relationships Between the Dark Triad and Schwartz's Circumplex of Values on High School Students
Authors: Uçar Mehmet Ertuğrul , Konal Bilge
Published: May 2024

Values are abstract ideals to be achieved and serve as criteria for individual behavior, choices, and self-evaluation. Schwartz defined 10 universal values in his Theory of Values and created four value groups that group together related values. The Dark Triad consists of negative behaviors such as using others for personal gain, egocentrism, cheating, and manipulating others. The purpose of this research is to test whether Machiavellianism, psychopathy, and narcissism, which are the dimensions of the Dark Triad, predict Schwartz's value groups of conservatism, self-enhancement, openness to change, and self-transcendence through the implicit variable of the Dark Triad. A MIMIC model was developed and tested for this purpose. The MIMIC model is used to determine whether a large number of observed variables predict a latent variable and whether this latent variable causes a large number of cases. The results of the research indicated that Machiavellianism, psychopathy and narcissism predicted the values of power, success and hedonism in the self-enhancement value group through the Dark Triad implicit variable. It was also found to negatively predict the values of universality, benevolence and conformity. Notably, the Dark Triad and its dimensions do not predict conservatism and openness to change.
The Shrinking City as a Testing Ground for Urban Degrowth Practices
Authors: Hermans Maurice , De Kraker Joop , Scholl Christian
Published: May 2024

To inform and operationalize an urban degrowth agenda, more systematic and larger-scale experimentation with degrowth practices is needed. The aim of this study was to explore the suitability of shrinking cities as testing grounds for urban degrowth practices. To answer this question, we analyzed two cases, both urban greening initiatives, located in the shrinking urban region of Parkstad Limburg, in the Netherlands. The cases show that in a shrinking city, with a large surplus of urban land and long-term vacancy and demolishing of buildings, there is literally abundant “room” to experiment with alternative ways and types of urban land use. There is also interest on the side of the local government in alternatives to the conventional approaches to urban planning and development. As both cases can be interpreted as “experiments with urban degrowth practices,” it can be concluded that shrinking cities offer ample opportunities for urban degrowth experiments. The lessons learned from the two studied cases are not very positive concerning the wider feasibility of the tested degrowth practices, but as experiments, the cases can be considered successful. This is because they provided a better understanding of the conditions required for the implementation and upscaling of these practices, also in growing cities. To inform and operationalize an urban degrowth agenda, we, therefore, recommend more research on cases in shrinking cities that can be interpreted and analyzed as experiments with urban degrowth practices.
LEGAL REGULATION OF PSYCHOSOCIAL SUPPORT AT THE WORKPLACE IN WARTIME CONDITIONS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Sakharuk Iryna
Published: May 2024

Background. The article introduces the study of the legal foundations of the implementation policies and practices for psychosocial support of employees. In national legislation and the doctrine of labour law, there is remains predominant the understanding of occupational health as compliance with the norms of safety technology and industrial sanitation. At the level of international labour standards, more and more emphasis on occupational safety management is shifting to psychological safety. In the conditions of a full-scale war in Ukraine, the issues of psychosocial support of employees become especially relevant. The workplace itself can and should become an important centre of psychological stability, support and help. Methods. The dialectical method, historical method, comparative-legal and formal-logical methods were used to reveal the subject. The empirical basis is the reporting documents based on the results of piloting psychosocial support programs at the workplace in Ukraine. Results. The article defines the legal basis for the regulation of psychological working conditions at the international and national levels. It has been made the pproposals to improve the labour legislation of Ukraine in order to take psychosocial risks into account in the labour protection management system. The author analysed the results of piloting programs of psychosocial support at the workplace, the algorithm for introducing the relevant programs. The article presents the idea that the issue of protection against psychosocial risks can be regulated by local acts and become an integral part of the organizational culture of each employer. Conclusion. The legal institute of labour protection in Ukraine needs reinterpretation. In the future, a national program for strengthening mental health at work should be developed. At the same time, it is already necessary to improve labour legislation in order to integrate psychosocial risks into risk assessments as part of occupational health and safety management systems. Improvement of the psychological climate has a local nature, therefore it should be ensured with the help of cooperation between the employer and the employees. The pressing need, especially given the increased stress level in the conditions of full-scale war, is the implementation by every employer of permanent practices and policies of psychosocial support of employees.
COMPENSATION FOR DAMAGES CAUSED BY WAR: INVESTIGATING THE ISSUE USING THE EXAMPLE OF ARMED AGGRESSION BY THE RUSSIAN FEDERATION AGAINST UKRAINE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Izarova Iryna , Uhrynovska Oksana ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Hartman Yuliia ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: May 2024

Background. War is synonymous with destruction, encompassing both property losses and the lives and health of ordinary citizens. The damages suffered by Ukraine and its citizens during years of occupation of territories and war actions are calculated in millions, although it is difficult to definitively establish both the methodology for calculations and the specific figures. To restore justice, it appears far more critical to define a fair, transparent, and understandable procedure for compensating the damages inflicted upon citizens and businesses due to these events. This becomes especially crucial in the context of meeting sustainable development goals, particularly ensuring equal access to justice for all. This article is dedicated to these issues and their related aspects. Methods. To determine the procedure for compensating losses and damages caused by war, we initially identified what can be compensated and who can file a compensation claim. These and other factors determine the specifics of the procedure for restoring rights and compensating for the harm caused by war in Ukraine. In seeking answers to these questions, we analyzed the current legislation of Ukraine and drafted laws proposed to regulate relations associated with compensation for damages. A comprehensive analysis of concepts such as losses, damages, compensation, reparations, and indemnification, as defined in national legislation and international agreements, was also conducted. Summarizing the judicial practices of national courts (more than 250 analyzed decisions of first-instance, appellate, and cassation courts from February 20, 2014, to September 1, 2023, examples of which are provided in the study) indicates the existence of different approaches to compensating for harm in terms of restoring violated citizens' rights. Results. To develop potential solutions to these problems, an analysis of the experiences of countries that faced similar events was conducted. Particular attention is given to the practice of the European Court of Human Rights, which holds significant importance for Ukraine (decisions on cases concerning compensation for damages caused by occupation). Conclusions. In conclusion, it is proposed to determine approaches to the application of compensation and indemnification institutions, aligning them with international approaches and under societal expectations to identify the most effective forms of protection for these rights based on defined criteria.
FEATURES OF THE RECEPTION OF ROMAN LAW IN THE GRAND DUCHY OF LITHUANIA
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Kryzhevskyi Anton
Published: May 2024

Background. The purpose of this study is to carry out a comprehensive historical and legal analysis of the chronology and geography of the ways of Roman law reception into the legal system of the Grand Duchy of Lithuania (GDL). Methods. The validity of theoretical propositions, conclusions, scientific analysis and the reliability of research results is ensured by the use of a complex of philosophical, general scientific and special scientific methods, namely: historical-legal, comparative-legal, historical-functional, formal-legal, and legal methods, etc. The research was conducted from the standpoint of the principles of historicism, objectivity, universality, complementarity, and reasonableness, which created a reliable methodological basis for a comprehensive analysis of the research subject. Results. The article analyzes Western and Eastern European types of Roman law reception, their geography, and chronological boundaries. The author singled out numerous legal norms that, in essence, being the norms of the received Roman-Byzantine law, were perceived as customary law in the GDL. It is proved that the reception of Roman law in the GDL from Byzantium took place earlier than from Western Europe. It has been established that the norms of Roman-Byzantine law were borrowed from the ecclesiastical legislation of Byzantium or through state legal acts, in which secular norms were closely intertwined with Christian legal provisions. Conclusions. Based on the analysis of the chronology and geography of the reception of Roman law in the Grand Duchy of Lithuania, the author concludes about the significant influence of Roman-Byzantine law on the formation and development of the principality's legal system. It is substantiated that this influence is connected with the process of reception of Roman-Byzantine law in the Rus' law of the pre-Mongol period and with the further spread and evolution of the received legal norms in the form of various legal forms in rights of the Grand Duchy of Lithuania.