bluuebunny/crossref_metadata_2025 huggingface dataset:
Leaf Punch DNA Extraction v2
Authors: Rajewski Alex , McGregor Cecilia
Published: March 2019

This is a quick (and very cheap) genomic DNA extraction protocol for fresh leaf or seed tissue in many plant species. It should be use preferably for extractions that do not require exceptional lengths of DNA, and is suitable for routine PCR, sanger sequencing, and restriction digests. The protocol is modified from Edwards et al. Nucleic Acids Research 19(6): 1349, and has been adapted since then by Zach King, Jonathan Serrano, and Cecilia McGregor. Typical yeilds of DNA are ~200ng/µL.
Real-Time Surround-View System for Mobile Robotic System
Authors: Varlashin V. V. , Ershova M. A. , Bunyakov V. A. , Shmakov O. U.
Published: March 2019

The paper is devoted to the problem of increasing the adequacy of perception of the environment by the mobile robot operator using remote control. A variant of a real-time surround-view system for mobile robot based on the multiple cameras with fisheye lenses and overlapping fields of view is proposed. A prototype of the circular view system has been developed. In this paper, the key features of the architecture and software of the surround-view system are considered. The algorithms for determining the internal parameters of cameras and distortion correction are researched. New models for describing the distortions of wide-angle and fisheye lens are used. Algorithms for finding the external parameters of cameras, as well as homography matrices using invariant descriptors, are implemented. Static homography matrices are used during stitching images into panorama. Various image-stitching techniques based on the overlapped images region blending are investigated and implemented. The methods of projective geometry and augmented reality were studied to obtain a perspective third-person view. A surface variant for projecting panorama of a surround view is proposed. For the implementation of the software selected cross-platform game engine "Unity". Directions for further research are identified.
Behavior of Cast {TI OR TA}-Containing Alloys Based on Nickel and/or Cobalt in High Temperature Oxidation:Effect of the NI/ CO Ratio
Authors: BERTHOD Patrice , Himeur Zahra , Toubal Lydia , Abed Ouarda , Léglise Mélissa
Published: March 2019

Many of the cast superalloys chosen for specific applications at high temperatures, such as tools devoted for shaping molten glass, are based on nickel or cobalt. They contain chromium and carbon to achieve good resistances against both mechanical stresses and hot oxidation/corrosion, by favoring the formation of reinforcing carbides at solidification and the development of a protective oxide scale of chromia during service. In presence of tantalum or titanium in the chemical composition of the alloys, high performance MC carbides may be obtained but this depends on the base element. One recently observed how the respective proportions of nickel, cobalt and chromium may promote the formation of TiC or TaC at the expense of chromium carbides. The ratings chosen for No, Co and Cr may have high influence on the oxidation of the alloys at high temperature this is what was studied in this work.
Prevalence of hyperuricemia in newly diagnosed type 2 diabetes mellitus patients
Authors: Grover Ankit , Mowar A. B. , Johri Sharat
Published: March 2019

Background: The relationship between hyperuricemia and diabetes mellitus is proved to be associated with the risk of cardiovascular diseases, but it is unclear whether hyperuricemia is actually related to diabetes.Methods: A 50 patients with newly diagnosed diabetes according to ADA guidelines were selected. Uric acid level and HbA1C levels were measured. Results were calculated with the reference range of uric acid >7.0 mg/dl.Results: The mean serum uric acid level was higher in 72% of the newly diagnosed diabetic patients (36/50).Conclusions: Hyperuricemia seems to be associated with newly diagnosed diabetics. It can be used as a biomarker of deterioration of glucose metabolism.
A study of cardiac changes in asymptomatic diabetic patients in comparison with normal population
Authors: Bendigeri Mukhtarahmed , Sadique Rizwan P. , Aziz Asbin Abdul , Jaladhar Prakruthi
Published: March 2019

Background: India is predicted to bear the greatest Coronary artery disease (CAD) burden, according to the estimates from the global burden of disease study. Majority of the time the patient of diabetes presents with complications like Myocardial infarction (MI), heart failure, being end stages of cardiovascular disease associated with other macro and micro-vascular complications.Methods: This study was done in view of screening the asymptomatic diabetic individuals presenting to our hospital for any evidence of early cardio-vascular manifestations. With the aid of non-invasive testing such as electrocardiography (ECG) and 2D echo the early changes were noted and compared with the normal population and the cardiac status thus evaluated. A total of 106 patients (53 were diabetic and 53 non-diabetic controls) were included in the study in order to compare the ECG and 2D echo findings among the population. The main aim of the present study was to observe the ECG manifestations in diabetic patients without overt symptoms of any cardiac disease and to evaluate the ECG changes along with 2D echocardiogram in asymptomatic diabetic patients and compare with normal population.Results: From the study, it was observed that majority among the diabetic population were found to have statistically significant changes in the ECG like PR interval prolongation, T wave inversions and QT interval prolongation. 2D ECHO studied showed the presence of Left ventricular diastolic dysfunction and Regional wall motion abnormalities to be evident among the diabetic population.Conclusions: It was concluded from the study that diabetic patients have a higher risk of cardiovascular morbidities compared to the general population and ECG changes are observed even when they are clinically asymptomatic. This observation has been confirmed by the 2D echo findings. It is essential to screen diabetic patients at an early stage to prevent cardiovascular complications. ECG being a relatively cheap and non-invasive investigation should be utilized to screen diabetics for the same.
A retrospective study of clinical profile and outcome of patients with rodenticide poisoning in a tertiary care hospital
Authors: Balasubramanian Kavitha , Sethuraman Vinoth Kumar , Balamurugesan Kandan , Viswanathan Stalin
Published: March 2019

Background: In developing countries, the substances most commonly used for self-poisoning are agricultural pesticides including rodenticides. Authors aimed to assess the clinical status and outcomes of patients with rodenticide poisoning in a tertiary care hospital.Methods: This retrospective record-based study was carried over three years. Apart from demographic details, information regarding the time of ingestion, nature and amount of the compound. Other details included clinical features, complications, treatment and outcome of the patient. Descriptive analysis was carried out by the mean and standard deviation for quantitative variables, frequency and proportion for categorical variables.Results: Of the 120 study subjects, 85 (93.40%) participants self-harmed, 2 (2.20%) were homicidal, and 4 (4.40%) had accidentally consumed the rodenticide. About 52 (32.70%) participants had vomiting, 34 (21.38%) had giddiness, 32 (20.13%) participants had abdominal pain. On the whole, 85 (73.28%) participants recovered, 23 (19.83%) participants had absconded, 6 (5.17%) participants had referred and 2 (1.72%) of them expired.Conclusions: Phosphorous compounds, particularly yellow phosphorous are the most lethal rodenticides followed by Coumadin. Symptomatic management of the patients at the earliest possible time is the mainstay, as there are no specific antidotes for any of the compounds.
In vitro effects of compounds isolated from Sideritis brevibracteata on bovine kidney cortex glutathione reductase.
Authors: Tandogan Berivan , Güvenç Ayşegül , Çalış İhsan , Ulusu Nuriye Nuray
Published: March 2019

Glutathione reductase (GR, E.C 1.6.4.2) is a flavoprotein that catalyzes NADPH-dependent reduction of oxidized glutathione (GSSG) to reduced glutathione (GSH). The aim of this study was to investigate in vitro effects of phenolic compounds isolated from Sideritis brevibracteata on bovine kidney GR. The Sideritis species are widely found in nature and commonly used as medicinal plants. 7-O-glycosides of 8-OH-flavones (hypolaetin, isoscutellarein and 3'-hydroxy-4'-O-methylisoscutellarein) were isolated from aerial parts of Sideritis brevibracteata. These compounds inhibited bovine kidney cortex GR in a concentration-dependent manner. Kinetic characterization of the inhibition was also performed.
Cytotoxicity of PP(Arg)(2)- and Hp(Arg)(2)-mediated photodynamic therapy and early stage of apoptosis induction in prostate carcinoma in vitro.
Authors: Nowak-Stępniowska Agata , Wiktorska Katarzyna , Małecki Maciej , Romiszewska Anna , Padzik-Graczyk Alfreda
Published: March 2019

Porphyrin photosensitizers tend to localize in mitochondria. The depolarization of mitochondrial membrane is one of the early stages of apoptosis and Laser Scanning Fluorescence Microscopy allows to determine changes in transmembrane mitochondrial potential under influence of PDT depending on the kind of photosensitizer (PP(Arg)(2), Hp(Arg)(2)), the energy dose (5, 10, 30 and 50 J/cm(2)) and time periods (24 and 48 hours after irradiation) in the LNCaP (lymphonodal metastasis of prostate carcinoma, the androgen dependent cell line). Cyototoxicity induced by PP(Arg)(2)- and Hp(Arg)(2)-based PDT depending on energy dose and time after irradiation in prostate carcinoma is determined with MTT. Generally, it was shown that lower energy doses induce greater changes in transmembrane mitochondrial potential. Hp(Arg)(2)-based PDT was more effective causing greater mitochondrial membrane depolarization and cell viability decrease in comparison to PP(Arg)(2)-mediated PDT (in the case of maximal nontoxic photosensitizer doses used).
Impact of DNA microarray data transformation on gene expression analysis - comparison of two normalization methods.
Authors: Schmidt Marcin T , Handschuh Luiza , Zyprych Joanna , Szabelska Alicja , Olejnik-Schmidt Agnieszka K , Siatkowski Idzi , Figlerowicz Marek
Published: March 2019

Two-color DNA microarrays are commonly used for the analysis of global gene expression. They provide information on relative abundance of thousands of mRNAs. However, the generated data need to be normalized to minimize systematic variations so that biologically significant differences can be more easily identified. A large number of normalization procedures have been proposed and many softwares for microarray data analysis are available. Here, we have applied two normalization methods (median and loess) from two packages of microarray data analysis softwares. They were examined using a sample data set. We found that the number of genes identified as differentially expressed varied significantly depending on the method applied. The obtained results, i.e. lists of differentially expressed genes, were consistent only when we used median normalization methods. Loess normalization implemented in the two software packages provided less coherent and for some probes even contradictory results. In general, our results provide an additional piece of evidence that the normalization method can profoundly influence final results of DNA microarray-based analysis. The impact of the normalization method depends greatly on the algorithm employed. Consequently, the normalization procedure must be carefully considered and optimized for each individual data set.
Detection and identification of potentially toxic cyanobacteria in Polish water bodies.
Authors: Głowacka Joanna , Szefel-Markowska Magdalena , Waleron Małgorzata , Łojkowska Ewa , Waleron Krzysztof
Published: March 2019

The main goal of this study was to determine the distribution of potentially toxic cyanobacteria in 39 selected Polish water bodies. From the water bodies with blooms and also from those in which blooms were not visible 87 samples were investigated. For the first time samples from ponds localized in villages with high agricultural activities were included. Lakes for which microcystin concentrations had been determined before were included as a reference for the research. The detection of cyanobacteria was conducted by microscopic observation as well as by PCR amplification of the rpoC1 gene fragment. Cyanobacteria were present in 75 out of 87 samples. The presence of potentially toxic cyanobacteria was detected by amplification of the mcyB and mcyE genes, which are involved in the biosynthesis of microcystins. Both genes were detected in 7 out of 9 blooms investigated. In the case of samples collected from water bodies in which blooms were not observed, the mcyB and mcyE genes were detected in 20 out of 36. In order to identify the cyanobacteria occurring in selected reservoirs, 16S plus ITS clone libraries were constructed. The method allowed distinguishing 18 different genotypes. After sequence analysis, cyanobacteria belonging to genera Microcystis, Planktothrix, Anabaena, Pseudanabaena, Synechocystis, Synechococcus and Woronichinia were identified. Results confirmed the usefulness of the rpoC1 and mcy genes for monitoring water bodies and detection of potentially toxic cyanobacteria. Application of molecular markers allowed detecting potentially toxic cyanobacteria before the bloom was visible. This is the first comprehensive study concerning cyanobacteria present in different types of Polish water bodies performed using molecular markers.
Analysis of potyvirus terminal protein VPg-transgenic Arabidopsis thaliana plants.
Authors: Wojtal Izabela , Piontek Paulina , Grzela Renata , Jarmołowski Artur , Zagórski Włodzimierz , Chroboczek Jadwiga
Published: March 2019

Virus-coded VPg protein of Potato virus Y (PVY) does not have homologs apart from other VPgs. Since VPg is indispensable for the potyvirus life cycle, it appeared a good candidate for eliciting pathogen-derived resistance to PVY. Following agroinfection used to obtain PVY VPg-transgenic Arabidopsis thaliana plants, only few transgenic seeds were recovered giving rise to six transgenic plants that contained the VPg gene with the correct sequence. They generated VPg mRNA, but VPg protein was not detected. Some plants were immune to PVY infection suggesting post-transcriptional gene silencing. However, the likely PVY VPg toxicity exerted at an early stage of transformed seeds development precludes its use for engineering pathogen-derived resistance.
Subcellular localization of UDP-GlcNAc, UDP-Gal and SLC35B4 transporters.
Authors: Maszczak-Seneczko Dorota , Olczak Teresa , Olczak Mariusz
Published: March 2019

The mechanisms of transport and distribution of nucleotide sugars in the cell remain unclear. In an attempt to further characterize nucleotide sugar transporters (NSTs), we determined the subcellular localization of overexpressed epitope-tagged canine UDP-GlcNAc transporter, human UDP-Gal transporter splice variants (UGT1 and UGT2), and human SLC35B4 transporter splice variants (longer and shorter version) by indirect immunofluorescence using an experimental model of MDCK wild-type and MDCK-RCA(r) mutant cells. Our studies confirmed that the UDP-GlcNAc transporter was localized to the Golgi apparatus only and its localization was independent of the presence of endogenous UDP-Gal transporter. After overexpression of UGT1, the protein colocalized with the Golgi marker only. When UGT2 was overexpressed, the protein colocalized with the endoplasmic reticulum (ER) marker only. When UGT1 and UGT2 were overexpressed in parallel, UGT1 colocalized with the ER and Golgi markers and UGT2 with the ER marker only. This suggests that localization of the UDP-Gal transporter may depend on the presence of the partner splice variant. Our data suggest that proteins involved in nucleotide sugar transport may form heterodimeric complexes in the membrane, exhibiting different localization which depends on interacting protein partners. In contrast to previously published data, both splice variants of the SLC35B4 transporter were localized to the ER, independently of the presence of endogenous UDP-Gal transporter.
Effect of Medicago sativa Mhb1gene expression on defense response of Arabidopsis thaliana plants.
Authors: Maassen Anna , Hennig Jacek
Published: March 2019

Besides the previously described nitric oxide-detoxification activity we identified new features of class-1 non-symbiotic hemoglobin from Medicago sativa (Mhb1). Under in vitro conditions, using peroxidase in-gel activity assay, the Mhb1 protein was shown to possess also peroxidase-like activity. Due to this activity, in the presence of nitrite and hydrogen peroxide, the protein can mediate autonitration and nitration of other proteins at tyrosine residues, as revealed by tandem mass spectrometry and immune assay approaches. Mhb1 through its multifunctional activities can affect different components of signal transduction cascades operating during plant response to infections. This influence is manifested by Mhb1-mediated selective up-regulation of expression of certain pathogen inducible genes in Pseudomonas syringae infected Arabidopsis thaliana plants which overproduce Mhb1, as revealed by reverse transcription-quantitative real-time PCR analysis. Changes in expression level of these genes can influence such processes as synthesis of secondary metabolites, protein degradation and biosynthesis of ethylene. They can also result in alteration of pathogen-induced defense response of Mhb1 transgenic plants.
The effect of sexual health counseling on women’s sexual satisfaction in postpartum period: A randomized clinical trial
Authors: Zamani Maryam , Latifnejad Roudsari Robab , Moradi Maryam , Esmaily Habibollah
Published: March 2019

Background: Many couples experience decreasing sexual satisfaction in postpartum period. Various sexual health counseling approaches have been designed for postpartum women to address their common sexual concerns and problems.
Objective: This study aimed to investigate the effectiveness of Women’s Postpartum Sexual Health Program (WPSHP) on women’s sexual satisfaction in postpartum period.
Materials and Methods: The study was a single blind randomized clinical trial on 75 postpartum women aged 18–35 yr with low sexual satisfaction who attended urban health-care centres in Mashhad, Iran in 2016. Data were collected using a demographic questionnaire, the Depression Anxiety Stress Scales-21, and the Larson Sexual Satisfaction Questionnaire. The intervention group received counselling based on the WPSHP, a four-session, group- and couples-based program. The control group  just received postpartum routine care.
Results: Both the intervention and control groups were homogeneous for demographic variables. According to the Mann-Whitney test, sexual satisfaction score in the  intervention group was significantly higher than the control group 8 weeks after the intervention (p < 0.001). According to the Wilcoxon test, there was a significant difference in the mean score of sexual satisfaction before and after intervention in the intervention group (p < 0.001).
Conclusion: WPSHP caused higher levels of sexual satisfaction. It is therefore recommended to use this program in women during the postpartum period to promote their sexual satisfaction.
Key words: Sexual satisfaction, Sexual counseling, Sexual health, Postpartum.
Easy to Believe in, But Difficult to Carry Out—Norwegian Midwives' Experiences of Promoting Normal Birth in an Obstetric-Led Maternity Unit
Authors: Aanensen Elisabeth Hemnes , Skjoldal Karin , Sommerseth Eva , Dahl Bente
Published: March 2019

PURPOSE

To explore and describe midwives' experiences of promoting normal birth in medicalized obstetric-led birth units in Norway.

STUDY DESIGN

A qualitative research design with an explorative/descriptive approach. A convenience sample of 10 midwives was recruited from 2 obstetric-led birth units.

MAJOR FINDINGS

Three main themes were identified. First, personal attributes and attitudes were perceived to influence the birthing process. Second, lack of time and impatient staff negatively affected the woman's chances of giving birth normally. Third, increasing focus on procedures, selection criteria, and technology threatened the use of midwifery skills and prevented midwives from promoting normal births.

MAIN CONCLUSION

Promoting normal birth is influenced by midwives' disposition and attitudes. It is therefore disturbing that midwives experience a loss of their autonomy and responsibility for normal births in obstetric-led wards.
017 El fenómeno del poder en enfermería en la academia y el área asistencial desde la perspectiva del docente
Authors: Rojas-Valenciano Ligia Patricia
Published: March 2019

Objetivo: Evidenciar los resultados de la dimensión de análisis titulada “El poder en enfermería” que forma parte del proyecto Sistematización de las experiencias de los y las docentes de la Escuela de Enfermería en la construcción de significados de enfermería desde la interpretación hermenéutica, aprobado por la Vicerrectoría de Investigación de la Universidad de Costa Rica con el código 421-B4-361.
Material y métodos: Se desarrollaron cinco sesiones con 15 profesores de la Escuela de Enfermería. Se trata de un estudio cualitativo aplicando el método hermenéutico dialéctico. El diseño utilizado es el que plantea Joseph A. Maxwell (1996). A partir de los datos se procedió a transcribir, reducir los datos y llevar a cabo el análisis interpretativo.
Resultados: De la dimensión “El poder en enfermería” surgieron dos categorías para el análisis e interpretación: 1. El poder desde la academia y 2. El poder desde las instituciones asistenciales de salud.
Conclusiones: La enfermería, al igual que en épocas pasadas, mantiene una posición de desventaja debido a la dominación y sumisión hacia otros profesionales, restándole importancia a su ejercicio del poder en el equipo de salud. Por lo tanto, se afecta la imagen o el modelaje que el docente de enfermería en el campo clínico debe mantener ante el estudiantado, lo que a su vez influye en la formación y validando las mismas posiciones de sumisión y dominación
Costo de recolocación de catéter central inserción periférica en neonatos de un hospital de tercer nivel
Authors: Ligonio-Aguayo Karla Irlanda , Martínez-Hernández Clara Magdalena , Santos-Padron Hilda
Published: March 2019

Objetivo: Determinar los costos por recolocación de catéter central de inserción periférica (PICC) por complicaciones mecánicas en neonatos de un hospital de tercer nivel.
Material y métodos: Estudio de análisis de costos de recolocación de catéter central de inserción periférica en el área de cuidados intensivos neonatales de un hospital de tercer nivel de Tabasco durante el año 2016. Para el cálculo de costos se elaboró un modelo de costeo adaptado del sistema ABC para ser aplicable en un hospital; se diseñó la fórmula: a + b + c + d + e. Para obtener el costo total de recolocación de PICC; donde a= Costo servicio personal por procedimiento para reparación del Evento Adverso X número de trabajadores participantes, b = Insumo requerido para reparar el Evento Adverso, c = Costo por auxiliar diagnóstico (USG, Tomografía, Rayos X, Labs.), d = Costo medicamento y material de curación utilizado por Evento Adverso, e = Número día estancia en UCIN X costo D-C-O en UCIN.
Resultados: Se revisaron 43 expedientes clínicos obtenidos de la base de datos del programa SICALIDAD del hospital; se identificaron 22 casos de ruptura de PICC, 20 casos por obstrucción, 1 caso por retiro accidental.
Conclusiones: El costo derivado de las 22 recolocaciones fue de $1,512,248.56 afectando los recursos financieros del hospital. Se observó una cadena de procedimientos e intervenciones altamente ge
La Satisfacción del usuario en los módulos de afiliación del Seguro Popular
Authors: Lopez Ronquillo José Julio
Published: March 2019

Objetivo: Caracterizar el nivel de satisfacción de los usuarios con respecto a la percepción de calidad del servicio recibida por el afiliador del Seguro Popular (SP). Materiales y Métodos: Estudio descriptivo prospectivo y transversal realizado en los módulos de afiliación y orientación (MAO) del municipio de Cárdenas, Tabasco, se aplicó un instrumento mixto tipo encuesta, diseñado con base al Modelo de Supervisión y Seguimiento Estatal de Servicios de Salud, operado por los Regímenes Estatales de Protección Social en Salud a nivel nacional hasta el año 2016, se tomaron los apartados de “atención” y “tiempo de espera”, adecuándose los ítems al contexto del proceso de atención durante la afiliación del usuario. El universo fue de 156,559 afiliados al SP, se calculó la muestra, utilizando un porcentaje de error del 6%, un nivel de confianza del 95% y una p=0.5, resultando una muestra de 266 beneficiarios. Resultados:El 92% fueron mujeres, la edad media de los usuarios fue de 32.62. El 98% respondieron estar satisfechos con la atención recibida en el MAO y que regresarían al mismo módulo a realizar trámites, siendo los principales motivos la ubicación y el trato recibido.En cuanto al tiempo de espera, el 73.7% de la población refirió estar muy satisfecho con el tiempo de espera, el 23.3% satisfecho, el 2.6% lo percibió como regular y el 0.4% quedó insatisfecho.Conclusiones:Los porcentajes obtenidos en los grados de satisfacción por la atención recibida y el tiempo de espera, demuestran amplia satisfacción con el servicio de los MAO, principalmente por el trato recibido y la ubicación del mismo. La comunicación entre el personal y el usuario, fue determinante en la satisfacción del afiliado.
La Farmacovigilancia en Cuba y la Infranotificaciones de Reacciones Adversas a los Medicamentos
Authors: Tarragó-Portelles Sury Saday , Gravier-Hernandez Rosario , Gil-del-Valle Lizette
Published: March 2019

Objetivo: Efectuar una revisión de los conocimientos sobre la Farmacovigilancia, el suministro de información sobre sospechas de RAM, que es tanto un deber moral para el médico y otros profesionales de salud como un aspecto de la atención al paciente y la infranotificación de estos reportes.
Material y métodos: La revisión fue realizada en las bases de datos LILACS, PAHO, SciELO, EMBASE, PubMed e Infomed, los motores de búsqueda Google y Google Scholar donde se colocaron palabras claves para la búsqueda de la información en artículos originales, tesis, otros artículos de revisión bibliográfica y revistas de elevado índice de citación publicados desde 1937 a 2017, en los idiomas español o inglés.
Resultados: Se identificaron 100 artículos, de los cuales 30 fueron seleccionados como útiles verificados para actualizar los conceptos relacionados con las disciplinas de Farmacovigilancia. En la práctica clínica existen varios factores que pueden dificultar la detección de las RAM y como consecuencia contribuir a la infranotificación.
Conclusiones: La infranotificación en Farmacovigilancia es una realidad mundial, observándose que la mayoría de las publicaciones analizadas que proceden de Europa (Alemania, España y Reino Unido) y en países de América Latina como Colombia, reconocen bajos índices de notificación
Investigation of Steady-State Heat Extraction Rates for Different Borehole Heat Exchanger Configuration from the Aspect of Implementation of New TurboCollectorTM Pipe System Design
Authors: Kurevija Tomislav , Kalantar Adib , Macenić Marija , Hranić Josipa
Published: March 2019

When considering implementation of shallow geothermal energy as a renewable source for heating and cooling of the building, special care should be taken in hydraulic design of borehole heat exchanger system. Laminar flow can occur in pipes due to usage of glycol mixture at low temperature or inadequate flow rate. This can lead to lower heat extraction and rejection rates of the exchanger because of higher thermal resistances. Furthermore, by increasing flow rate to achieve turbulent flow and satisfactory heat transfer rate can lead to increase the pressure drop of the system and oversizing of circulation pump which leads to impairment of seasonal coefficient of performance at the heat pump. Most frequently used borehole heat exchanger system in Europe is double-loop pipe system with smooth inner wall. Lately, development is focused on implementation of different configuration as well as with ribbed inner wall which ensures turbulent flow in the system, even at lower flow rates. At a location in Zagreb, classical and extended thermal response test was conducted on three different heat exchanger configurations in the same geological environment. With classic TRT test, thermogeological properties of the ground and thermal resistance of the borehole were determined for each smooth or turbulator pipe configuration. Extended Steady-State Thermal Response Step Test (TRST) was implemented, which incorporate series of power steps to determine borehole extraction rate at the define steady-state heat transfer conditions of 0/-3°C. Results show that heat exchangers with ribbed inner pipe wall have advantages over classic double-loop smooth pipe design, in terms of greater steady state heat extraction rate and more favorable hydraulic conditions.
Minimal Scar Formation After Orthopaedic Skin Incisions Along Main Folding Lines
Authors: Lemperle Gottfried , Knapp Dieter , Tenenhaus Mayer
Published: March 2019

Background:

Patients, particularly those who are young, often develop noticeable orthopaedic scars. In order to achieve minimal scarring, surgeons should attempt to place incisions in skinfolds or skin creases.

Methods:

Optimal incision lines can be determined from the direction of stretch marks (striae distensae), which develop perpendicular to lines of tension or main folding lines. A composite diagram of photographs of 213 individuals with striae distensae was created and compared with 276 images of incisions and scars derived from the Internet.

Results:

Classically described Langer cleavage lines often run counter to real tension lines and poorly predict the optimal direction for skin incisions.

Conclusions:

Whenever possible, main folding lines should be utilized as a guide in planning surgical incisions for young patients as well as for correction of problem scars.
Adaptation of Physics Metacognition Inventory to Turkish
Authors: KOYUNLU ÜNLÜ Zeynep , DÖKME İlbilge
Published: March 2019

This
study aimed to adapt the Physical Metacognition Inventory (PMI) developed by
Taasoobshirazi and Farley (2013) to Turkish. PMI consists of 24 items and six
factors. The scale items were translated into Turkish by the researchers, and a
Turkish-English comprehensibility form was prepared to elicit the opinions of
Turkish-English language experts. After making the necessary revision according
to the feedback of the experts, a confirmatory factor analysis (CFA) was undertaken.
A total of 554 students participated in the research, selected from prospective
teachers enrolled in the science teaching and classroom teaching programs
offered by education faculties or prospective engineers studying in engineering
faculties. The results of CFA revealed that the factors and related items of
the adapted scale were the same as in the original version. The reliability of
measurement was calculated as 0.93 for the whole scale. The adapted PMI
presented in this research can be applied to evaluate the level of
metacognition used by high school and university students in solving physics
problems.
Mortalidade de microempresas: um estudo de campo realizado com microempresários da região centro do Estado do Rio Grande do Sul
Authors: Perufo Larissa Disconzi , Godoy Leoni Pentiado
Published: March 2019

Em virtude da grande participação das microempresas na economia brasileira, e do alto índice de mortalidade destas, o contexto bibliográfico vem assumindo um papel importante neste meio, com o objetivo de compreender e minimizar os principais descuidos que levam o negócio a este patamar. Assim buscou-se através deste estudo identificar as principais causas que levam ao encerramento de microempresas. Para isto, optou-se por uma pesquisa de natureza qualitativa e quantitativa, exploratória e descritiva, realizada através de um estudo de campo. A partir da aplicação do questionário em microempresários da região central do estado do Rio Grande do Sul, os quais fecharam seus negócios com menos de três anos ativos, por diversas situações apresentadas, tornou-se possível a identificação da área de marketing como um campo bastante estratégico e pouco desenvolvido por parte dos entrevistados e adentro deste, o indicador considerado como umas das principais causas da mortalidade destas organizações foi a falta de controle dos resultados a partir da utilização das práticas de gestão da área, seguido da não utilização das técnicas de endomarketing.
Inovação e empreendedorismo: um caso no setor público
Authors: Teixeira Thatiana Stacanelli , Andrade Daniela Meirelles , Alcântara Valderi de Castro , Oliveira Naiara Kasmin de
Published: March 2019

Neste trabalho analisa-se o potencial e alcance da ação empreendedora na Administração Pública Brasileira. Este estudo de caso aborda dois fenômenos associados ao empreendedorismo: a inovação e o intraempreendedorismo. Foi realizado um estudo de caso único, em que a secretária responsável pela Secretaria de Cultura do município de Minas Gerais forneceu os dados para a estruturação do caso através de uma entrevista semiestruturada. Foi possível identificar traços marcantes dos dois fenômenos abordados neste estudo, sendo que ao unir as informações adquiridas através da entrevista junto ao conteúdo didático transcrito durante todo o trabalho, foi possível validar o conhecimento sobre o assunto de empreendedorismo no setor público e a realização deste na prática.
Crosstalk between the CX3CL1/CX3CR1 Axis and Inflammatory Signaling Pathways in Tissue Injury
Authors: Zhuang Quan , Ou Jiarui , Zhang Sheng , Ming Yingzi
Published: March 2019

During inflammation, chemokines play a central role by mediating the activation of inflammatory
cascade responses in tissue injury. Among more than 200 chemokines, CX3CL1 is a special
chemotactic factor existing in both membrane-bound and soluble forms. Its only receptor, CX3CR1, is a
member of the G protein-coupled receptor superfamily. The CX3CL1/CX3CR1 axis can affect many
inflammatory processes by communicating with different inflammatory signaling pathways, such as
JAK-STAT, Toll-like receptor, MAPK, AKT, NF-κB, Wnt/β-catenin, as well as others. These inflammatory
networks are involved in much pathology. Determining the crosstalk between the
CX3CL1/CX3CR1 axis and these inflammatory signaling pathways could contribute to solving problems
in tissue injury, and the CX3CL1/CX3CR1 axis may be a better therapeutic target than inflammatory
signaling pathways for preventing tissue injury due to the complexity of inflammatory signaling
networks.
What Pregnant Women Want: Results from a Web-Based Needs Assessment of Weight-Related Information Gaps and e-Health Intervention Features for Pregnant Women in the U.S. (Preprint)
Authors: Dahl Alicia , Turner-McGrievy Gabrielle , Wilcox Sara , Liu Jihong , Davis Rachel E.
Published: March 2019

BACKGROUND

Healthy gestational weight gain (GWG) is critical for reducing adverse pregnancy outcomes. Health care providers may not have the resources and specialized training to provide weight counseling to pregnant patients. Electronic health (e-health) interventions hold potential as important resources for pregnant women.

OBJECTIVE

This study identified weight-related knowledge and sources of prenatal health information and examined pregnant women’s feedback on features considered for inclusion in an e-health intervention targeted at preventing excessive GWG.

METHODS

Using social media sites, pregnant women in the U.S. who owned a smartphone were recruited to complete an online survey (n=329). The survey included questions regarding weight-related topics discussed with prenatal health providers, uses of technology for health information during pregnancy, interest in pregnancy weight-related information (e.g., physical activity), and features (e.g., weight tracking tool and podcasts) delivered electronically. ANCOVA and chi-square analyses were used to examine differences by parity and weight status.

RESULTS

Half of participants reported having no discussion about GWG recommendations with providers. Overall, interest in weight tracking, podcasts, and group-based behavioral challenges was high. Multiparous women expressed less interest in listening to weekly podcasts on pregnancy-related topics than nulliparous women (66.7% vs. 80.3%, p<0.01). Overweight/obese participants were more interested in a mobile app for communicating with other pregnant women than normal weight participants (86.5% vs. 77.3%; p=0.03).

CONCLUSIONS

Given the interest in e-health interventions among pregnant women, future studies should examine their effectiveness in the prevention of excessive GWG. Tailoring e-health intervention content based on parity and weight status may be necessary.

CLINICALTRIAL

NCT03063528
Três modelos pedagógicos para o ensino religioso escolar
Authors: Garutti Selson
Published: March 2019

RESUMO Atualmente em diversos eventos e debates relativos ao Ensino Religioso Escolar tem ocupado um importância espaço em pesquisas com relação à questão do lugar pedagógico ocupado pelo Ensino Religioso na Escola. Assim, pretende-se por objetivo investigar os três modelos pedagógicos possíveis para o Ensino Religioso Escolar: Catequético, Teológico e da Ciência da Religião (PASSOS, 2006; 2007); (SOARES, 2009; 2010). Para tanto, proem-se uma pesquisa bibliográfica documental baseada no método fenomenológico (MOREIRA, 2002). Conclui-se ser o método da Ciência da Religião o qual melhor atende as demandas educacionais da disciplina do Ensino Religioso Escolar.   Palavras-chave: Epistemologia. Educação. Ciências da Religião.       ABSTRACT Currently in several events and debates related to School Religious Education has occupied an important space in researches regarding the question of the pedagogical place occupied by Religious Education in the School. Thus, the objective is to investigate the three possible pedagogical models for School Religious Teaching: Caquetic, Theological and the Science of Religion (PASSOS, 2006; 2007); (SOARES, 2009; 2010). For that, a documental bibliographic research based on the phenomenological method is proposed (MOREIRA, 2002). It is concluded that it is the method of the Science of Religion which best meets the educational demands of the discipline of School Religious Education.   Keywords: Epistemology; Education; Sciences of Religion   RESUMÉN Actualmente en diversos eventos y debates relativos a la Enseñanza Religiosa Escolar ha ocupado un importante espacio en investigaciones con relación a la cuestión del lugar pedagógico ocupado por la Enseñanza Religiosa en la Escuela. Así, se pretende por objetivo investigar los tres modelos pedagógicos posibles para la Enseñanza Religiosa Escolar: Caquéctico, Teológico y de la Ciencia de la Religión (PASOS, 2006; 2007); (SOARES, 2009, 2010). Por eso, se prohíbe una investigación bibliográfica documental basada en el método fenomenológico (MOREIRA, 2002). Se concluye que es el método de la Ciencia de la Religión que mejor atiende las demandas educativas de la disciplina de la Enseñanza Religiosa Escolar.   Palabras clave: Epistemología. Educación. Ciencia de la religión.DOI: http://dx.doi.org/10.22169/revint.v13i30.1422
As contribuições do portfólio digital como instrumento de avaliação
Authors: Machado Mércia Freire Rocha Cordeiro , Silva Flávia Heloísa , Sakalauskas Silvia Renata
Published: March 2019

RESUMO Este artigo objetiva analisar, através da percepção de 21 estudantes de um Programa de Pós-graduação stricto sensu em Educação Profissional e Tecnológica em rede, as contribuições do portfólio digital como estratégia de avaliação, vinculando-o ao trabalho pedagógico e proporcionando uma participação mais efetiva dos alunos. Os dados foram coletados por meio de questionário e analisados através da Análise de Conteúdo (BARDIN, 2011). Conclui-se que este método promoveu uma prática inovadora de avaliação da aprendizagem, pautado na construção, reflexão, autoavaliação, criatividade, parceria e autonomia do ensinar e aprender aos envolvidos.   Palavras-chave: Portfólio Digital. Estratégia Avaliativa. Prática Inovadora. ABSTRACT This article aims to analyze the contributions of the digital portfolio as an evaluation strategy, through the perception of 21 students of a Postgraduate Program stricto sensu in Professional and Technological Education in network, linking it to pedagogical work and providing a more effective participation from the students. The data were collected through a questionnaire and analyzed through Content Analysis (BARDIN, 2011). It is concluded that this method promoted an innovative practice of evaluation of learning, based on construction, reflection, self-evaluation, creativity, partnership and autonomy of teaching and learning to those involved.   Keywords: Digital Portfolio. Evaluation Strategy. Innovative Practice.   RESUMEN Este artículo objetiva analizar, a través de la percepción de 21 estudiantes de un Programa de Postgrado stricto sensu en Educación Profesional y Tecnológica en red, las contribuciones del portafolio digital como estrategia de evaluación, vinculándolo al trabajo pedagógico y proporcionando una participación más efectiva de los alumnos. Los datos fueron recolectados por medio de un cuestionario y analizados a través del Análisis de Contenido (BARDIN, 2011). Se concluye que este método promovió una práctica innovadora de evaluación del aprendizaje, pautado en la construcción, reflexión, autoevaluación, creatividad, asociación y autonomía del enseñar y aprender a los involucrados.   Palabras clave: Portfolio Digital. Estrategia Evaluativa. Práctica Innovadora.  DOI: http://dx.doi.org/10.22169/revint.v13i30.1490
O que exprime o índice h5 da revista educação em questão (1987-2018)
Authors: De Araújo Marta Maria , Brito Max Brito Leandro de Araújo
Published: March 2019

RESUMO O presente a artigo trata do índice H5 das citações dos artigos da Revista Educação em Questão no período de 1987-2018, tendo como parâmetro a bibliometria do Google Acadêmico e suas respectivas métricas. Nesta abordagem, adotaram-se os postulados de cunho histórico descritivo e analítico e aqueles derivados dos estudos de cunho bibliométrico. A conclusão decorrente desta analise é a de que o índice H5 das citações dos artigos publicados na Revista Educação em Questão assinala desempenhos distintos entre os momentos sucessivos estudados (1987-2007 e 2008-2018) e ainda o fato de que, subjacente ao índice H5 das citações dos artigos desta Revista, coloca-se sua classificação no Qualis dos periódicos da Educação. Palavras-chave: Índice H5. Bibliometria. Periódico de educação.   ABSTRACT The present article deals with the H5 index of the articles' citations of the Journal Education in Question in the period of 1987-2018, having as parameter the bibliometrics of Google Scholar and its respective metrics. In this approach, we adopted historic motivated postulates, descriptive and analytical, and those deriving from bibliometric studies. The conclusion that emerges from this analysis is that the H5 index of the citations of the articles published in the Journal Education in Question points out different performances between the successive moments studied (1987-2007 and 2008-2018) and also the fact that, underlying the H5 index of the articles' citations of this Journal, we place its classification in the Qualis of the journals of Education. Keywords: H5 index. Bibliometrics. Journal of Education.   RESUMEN El presente a artículo trata del índice H5 de las citas de los artículos de la Revista Educación en Cuestión en el período 1987-2018, teniendo como parámetro la bibliometría de Google Académico y sus respectivas métricas. En este abordaje, se adoptaron los postulados de cuño histórico descriptivo y analítico y aquellos derivados de los estudios de cuño bibliométrico. La conclusión resultante de este análisis es la de que el índice H5 de las citas de los artículos publicados en la Revista Educación en Cuestión señala desempeños distintos entre los momentos sucesivos estudiados (1987-2007 y 2008-2018) y el hecho de que, subyacente al índice H5 de las citas de los artículos de esta Revista, se coloca su clasificación en el Qualis de los periódicos de la Educación. Palabras clave: Índice H5. Bibliometría. Periódico de educación. DOI: http://dx.doi.org/10.22169/revint.v13i30.1519
Logistic Regression: An Inferential Method for Identifying the Best Predictors
Authors: Wilcox Rand
Published: March 2019

When dealing with a logistic regression model, there is a simple method for estimating the strength of the association between the jth covariate and the dependent variable when all covariates are entered into the model. There is the issue of determining whether the jth independent variable has a stronger or weaker association than the kth independent variable. This note describes a method for dealing with this issue that was found to perform reasonably well in simulations.
Asociación entre temblor esencial y diabetes mellitus: estudio de casos y controles
Authors: Rueda-Sánchez Mauricio , Díaz-Martínez Luis Alfonso
Published: March 2019

INTRODUCCIÓN:
El temblor esencial es el temblor más común. No se ha descrito la asociación entre diabetes y temblor esencial. El objetivo de este estudio de casos y controles es documentar la asociación entre diabetes mellitus y temblor esencial.

MÉTODOS:
Se realizó un estudio de casos y controles en población clínica de pacientes incidentes con temblor esencial, pareados por edad y género, a quienes se les interrogó sobre antecedente de diabetes mellitus. Se determinó el OR mediante regresión logística condicionada.

RESULTADOS:
Se estudiaron 262 casos de temblor esencial y 262 controles. El antecedente de diabetes mellitus se encontró en 39 casos con temblor esencial y en 24 controles, lo que representa una asociación positiva entre los dos (OR 2,15, IC95 % 1,05 a 4,41).

DISCUSIÓN:
Este estudio de casos y controles en una población clínica muestra que los pacientes con temblor esencial tienen dos veces más probabilidad de tener el antecedente de diabetes mellitus.
Xantoastrocitoma pleomórfico anaplásico recurrente y respuesta a la combinación de carmustine y bevacizumab, un reporte de caso
Authors: Castro Christian David , Jiménez Enrique , Useche Nicolás , Hakim Fernando , Bermúdez Sonia , Rojas Leonardo , Ruiz-Patiño Alejandro , Cardona Andrés Felipe
Published: March 2019

Se expone el caso de una mujer de 19 años a quien se le realizó el diagnóstico de un xantoastrocitoma pleomórfico anaplásico parietooccipital izquierdo, neoplasia poco frecuente que suele presentarse en la población pediátrica y en los adultos jóvenes. Dicho tumor debuta generalmente con crisis convulsivas y sus características histológicas patognomónicas son el pleomorfismo celular, la vacuolización lipídica de su citoplasma y la reactividad a la proteína ácida fibrilar glial (PAFG) y S100. El estudio de nuevos marcadores que puedan brindar otras oportunidades terapéuticas ha permitido encontrar mutaciones en el oncogén BRAF. Este tumor presenta una variante anaplásica más agresiva que se trata con cirugía y quimiorradiación. En nuestro caso, después de varias progresiones a otras intervenciones, se utilizó bevacizumab y carmustine como tratamiento de segunda línea con respuesta completa.