bluuebunny/crossref_metadata_2025 huggingface dataset:
Understanding Interactions in a Classroom-As-Organization Using Dynamic Network Analysis
Authors: Cocieru Ovidiu C. , Katz Matthew , McDonald Mark A.
Published: December 2019

Background: The Classroom-as-Organization (CAO) is an experiential learning course in which students create and manage an organization as part of class activities. Student interaction with peers is an important feature of the CAO. Educators suggested that student interactions in CAOs follow certain patterns, but these observations have not been tested in empirical research. Purpose: The research focused on exploring patterns of interaction in a CAO. Methodology/Approach: Network data were collected from students and instructors at four different times during a two-semester CAO course. The authors then used social status theory, friendship formation literature, and Simulation Investigation for Empirical Network Analysis (SIENA) to test hypotheses about interactions in the CAO. Findings/Conclusions: The authors found evidence that (a) localized informal leaders emerge in the class, (b) reciprocation ties between individuals happens within, but not necessarily between departments, and (c) there is a close connection between class-related interactions and social interactions outside of the class, impacting leadership in the CAO. Implications: Instructors need to pay close attention to understanding and managing interdepartmental relationships in CAOs. Furthermore, educators may only have a limited understanding of CAO group dynamics, given that they may not have a high awareness of student social interactions outside of class.
An Examination of Undergraduate Conductor Practice Behavior
Authors: Regier Bradley J. , Scherer Alec D. , Silvey Brian A.
Published: December 2019

The purpose of this study was to examine undergraduate conductors’ personal approaches to conducting practice, practice time allocation, and beliefs about their conducting abilities. Participants ( N = 126) were undergraduate conductors enrolled in basic conducting courses at 17 NASM (National Association of Schools of Music)–accredited institutions. Our findings indicated that “patterns” and “dynamics” were the most practiced conducting behaviors. “Sing or hum musical lines” and “silent conducting practice” were the most used practice strategies. Through responses to open-ended items, participants shared that hand independence was the most challenging conducting skill and wished that it was discussed more by their conducting instructor, while “conducting patterns” was the skill that came most naturally. Undergraduate conductors practiced an average of 48 minutes per week across 2 to 3 days, and during practice sessions they used a score almost three fourths of the time. Implications for conducting practice and curricula are discussed.
Caring Masculinities in the Context of HIV Serodiscordant Relationships in Papua New Guinea
Authors: Mitchell Elke , Kelly-Hanku Angela , Mek Agnes , Trumb Richard Nake , Persson Asha , Worth Heather , Bell Stephen
Published: December 2019

Globally, there is limited research exploring the positive role men play in reducing HIV vulnerability or in the care and support of women living with HIV. This paper draws on interviews conducted with men and women in heterosexual HIV serodiscordant relationships as part of a longitudinal qualitative study exploring the social aspects of biomedicine among serodiscordant couples in two high HIV-burden areas in Papua New Guinea (PNG). Findings highlight that some HIV negative men in heterosexual relationships are resisting hegemonic masculine norms they see as harmful and are embracing caring masculine identities as they seek to support their HIV-positive wives. We suggest that understandings of masculinity in the context of the HIV epidemic in PNG should be broadened from simplistic discourses and representations of men as largely uncaring and violent to incorporate deeper understanding of how men can and are embracing caring masculinities.
The transnational ‘memorialization’ of monumental socialist public works in Eastern Europe
Authors: Preda Caterina
Published: December 2019

This article analyses how three types of artistic memorialization of monumental socialist public works transform these into examples of socialist modernism in Eastern Europe. First, it tackles the issue of rendering socialist architecture visible through the Socialist Modernism online platform. Second, it focuses on the collection of documentary proofs by six documentary photography projects in Eastern Europe. Finally, it looks at how four contemporary artists in Bulgaria, Romania, Lithuania, and the Czech Republic are resignifying socialist art in their artistic practices. Analysed from a perspective of transnational cultural memory practices, these three artistic endeavours contribute to a shared approach to the monumental socialist public works in the region. I argue that some of these strategies lead to a unified, depoliticized, decommunized memorialization of the socialist art of Eastern Europe.
Sexual violence at live music events: Experiences, responses and prevention
Authors: Hill Rosemary Lucy , Hesmondhalgh David , Megson Molly
Published: December 2019

Recent media reporting has highlighted that incidents of sexual violence frequently occur at live music events. Sexual violence has significant impacts on the health of those who experience it, yet little is known of how it impacts on everyday engagements with music, nor what measures venues and promoters might take to prevent and respond to incidents. Through interviews with concert goers, venue managers, promoters and campaigning groups, we investigated experiences of sexual violence at indie, rock, punk and funk gigs in small venues in one English city. We show that sexual violence at live music events significantly impacts on (predominantly) women’s musical participation. We argue that venues and promoters must work proactively to create musical communities that act as a defence against the normalisation of sexual violence, taking inspiration from safer space policies.
Integrating GIS and statistical approaches to enhance allocation of highway patrol resources
Authors: Rezapour Mahdi , Yue Er , Ksaibati Khaled
Published: December 2019

Large truck crashes undermine the contribution of trucks to the U.S. economy due to the economic costs of the crashes. Wyoming has the highest truck crash rate and the lowest budget contribution for traffic enforcement in the USA. Because of the state’s intensive truck corridors, the Wyoming Highway Patrol (WHP) might not be able to use their resources efficiently. Previous studies have indicated that WHP performed better when they allocate their resources efficiently at the right locations and towards the right enforcements. This study used 4-year historical crash and enforcement data along Interstate 80 (I-80), which has the highest truck-related crash rate in Wyoming. Crash data were filtered to include truck crashes only. However, both truck and no-truck enforcements were included in the data because both could be at fault in truck crashes. This study used two approaches to help state policy-makers improve traffic safety on I-80. First, a statistical method was used to identify geometric variables contributing to allocated enforcement and truck crashes. Second, truck crashes and related enforcements were visually assessed using Geographical Information Systems (GIS) mapping. Crash data were disaggregated into the main driver actions of no improper driving, following too closely, improper lane change and driving too fast for the conditions. These driver actions accounted for more than 70% of all truck crashes on I-80. Related enforcements were also identified and disaggregated by driver actions. Disaggregated enforcements and crashes were visualized along the I-80 corridor using GIS maps to see if WHP allocated their resources efficiently. Cluster index, enforcement spatial coverage and mean density are some of the parameters used for the analyses. This study aimed to contribute to research on police effectiveness in reducing truck crashes, police innovation and the use of GIS applications in enforcement. This methodology can be used by other agencies to better allocate resources to improve traffic safety in most efficient ways.
Professional and academic knowledge in teachers’ research: An empowering oscillation
Authors: Bergmark Ulrika , Erixon Per-Olof
Published: December 2019

In this article, we study the academisation of the teaching profession in Sweden, which follows contemporary trends in other Nordic and European countries. The specific aim was to analyse 14 reports written by researching teachers enrolled in a master’s programme to investigate how they perceive, interpret and value academic and professional knowledge. The conceptual framework comprises theories concerning academic literacies and knowledge structures. The report analysis focussed on scope, aims and research questions, and how the researching teachers related to teacher knowledge and academic knowledge, normativity and a critical approach. After a preliminary analysis, the researching teachers were invited to participate in the analysis, giving their contextual understanding. The study indicates that the reports were based on empirical data and situated in a professional context, with the aim of exploring and understanding professional issues in relation to research, national policies and professional teacher experience. Report orientation was deeply nourished by teacher knowledge. The researching teachers’ contextual knowledge both benefitted and challenged academic knowledge and vice versa, with the ambition to improve practice. Accordingly, the teachers’ contextual knowledge can deepen the understanding of a research phenomenon. There was an empowering oscillation between teacher knowledge and academic knowledge in the teachers’ research.
Paired Interviews to Evaluate Patient and Proxy Responses on Patient Experience of Care Surveys (PECS)
Authors: Zuckerbraun Sara , Allen Rachael Welsh , Flanigan Tim
Published: December 2019

Paired interviews are used to evaluate whether a questionnaire functions properly for both the target respondent and an alternate respondent (proxy). We developed a new application of this tool to evaluate whether a Patient Experience of Care Survey (PECS) for long-term care hospitals (LTCHs) and inpatient rehabilitation facilities (IRFs) functioned acceptably for patients and their family members. Frequently, patients in LTCHs and IRFs cannot fully recall their care experience and are often unable to complete surveys because of cognitive or physical limitations. For this project, researchers conducted interviews with 20 paired respondents: a patient and a proxy. Results revealed that the patient and their proxy went through similar response strategies and answered questions similarly to each other a majority of the time. We concluded that the questionnaires function acceptably for patients and proxies.
Off-the-Shelf Devices for Treatment of Thoracic Aortic Diseases: Midterm Follow-up of TEVAR With Chimneys or Physician-Made Fenestrations
Authors: Zhang Lei , Wu Meng-tao , Zhu Guang-lang , Feng Jia-xuan , Song Chao , Li Hai-yan , Jing Zai-ping , Yeung Kak Khee , Lu Qing-sheng
Published: December 2019

Purpose: To evaluate the midterm outcomes of thoracic endovascular aortic repair (TEVAR) using chimney grafts (ch-TEVAR) or thoracic stent-grafts with fenestrations made on the back table (f-TEVAR) to treat thoracic aortic dissection (TAD) and thoracic aortic aneurysm (TAA). Materials and Methods: A retrospective analysis was conducted of 474 consecutive patients (mean age 62.3±10.7 years; 346 men) treated with either f-TEVAR (n=110) or ch-TEVAR (n=364) for 352 TADs (81 f-TEVAR and 271 ch-TEVAR) or 122 TAAs (29 f-TEVAR and 93 ch-TEVAR) from 2008 to 2016. The primary endpoints at 30 days and during follow-up were overall mortality, aorta-related mortality, and major complications. The secondary endpoints were endoleak and reintervention. The patency of the target branches, cost of hospitalization, and the use of antiplatelet drugs were also analyzed. Results: Intraoperative type I endoleaks were treated in 69 (14.6%) cases (4 f-TEVAR and 65 ch-TEVAR, p<0.01) to achieve 100% technical success. Four (0.8%) patients died within 30 days [1 (0.9%) f-TEVAR and 3 (0.8%) ch-TEVAR]. Perioperative cerebral ischemia (1 fatal stroke) occurred in 9 (1.9%) patients: (1 f-TEVAR and 8 ch-TEVAR, p=0.39). During the mean follow-up of 50.6±20.0 months (49.5±18.3 months in f-TEVAR and 50.9±20.6 months in ch-TEVAR), 11 (2.3%) patients died of an aorta-related event. Type I endoleak was present in 40 (8.4%) patients (1 f-TEVAR and 39 ch-TEVAR, p<0.01). Eleven (2.3%) patients experienced stent-graft migration and 13 (2.7%) had a retrograde dissection. One hundred (16.9%) of the 593 branch stents occluded (4/75 in the f-TEVAR group and 96/518 in the ch-TEVAR group, p<0.01). The branch reintervention rate was 7.2% (34/474). The f-TEVAR group had a significantly higher probability of freedom from branch occlusion (92%) than the ch-TEVAR group (83%, p=0.007). Conclusion: Off-the-shelf techniques employing chimney grafts and homemade fenestrations are both suitable options for TAD and TAA involving the supra-aortic branches, with a low incidence of reintervention. Fenestrated TEVAR seems to have more favorable short- and midterm outcomes. Further study of these off-the-shelf techniques for aortic arch repair is warranted.
Testing the effect of textile materials on car seat comfort in real traffic
Authors: Havelka Antonín , Nagy Ladislav , Tunák Maroš , Antoch Jaromír
Published: December 2019

This study proposes a methodology that enables the comparison of textile materials from the point of view of corresponding comfort. Although this study focuses on textile materials used for the construction of car seats, the approach can be used more broadly. First, different aspects, which are more or less closely connected with our problem, are discussed. Among them, two characteristics, i.e. temperature conductivity and breathability, are important. Second, we discuss why it is important to have conclusions about comfort based not only on the subjective feelings of evaluators, but also on objective measurements. To that purpose, an experiment and a questionnaire summarising subjective feelings are proposed and concisely described. Furthermore, the choice of sensors, their placement in a car seat and the manner of recording data are discussed. Finally, the choice of appropriate statistical methods suitable for the analysis of collected data is discussed. The approach is illustrated via real experiments. Our findings support the current trend that the use of 3D spacer fabrics improves both breathability and sitting comfort in general.
Applications of optical frequency-domain reflectometry technology in strain-deformed configuration conversion of structural surface deformed configuration measurement
Authors: Zhang Zhenglin , Sun Yangyang , Zhang Qinghua , Duan Jianli , Gao Lei
Published: December 2019

In this study, the conversion relation between deformed configuration and strain during structural monitoring was analyzed based on the basic mechanics principle of materials. A distributed fiber optic measurement system was used to measure the accurate values of structural surface strain, and then calculate the intensity of surface-deformed configuration further. An optical fiber was attached to the surface of a flexible steel ruler, and the generated strain data were used to precisely measure the endpoint-deformed configuration of the ruler. Furthermore, the calculated deformed configuration was calculated and compared with the actual deformed configuration. It was found that the curves of calculated deformed configuration basically coincided (with a relative error of less than 0.6%) with the curves of actual deformed configuration.
A Decalogue to Avoid Routine Ileostomy in Selected Patients With Border Line Risk to Develop Anastomotic Leakage After Minimally Invasive Low-Anterior Resection: A Pilot Study
Authors: Morales-Conde Salvador , Alarcón Isaias , Yang Tao , Licardie Eugenio , Balla Andrea
Published: December 2019

Purpose. Protective ileostomy (PI) during anterior resection (AR) for rectal cancer decreases the incidence of anastomotic leakage (AL) and its subsequent complications, but it may itself be the cause of morbidity. The aim is to report our protocol in the management of selected patients with borderline risk to develop AL after laparoscopic AR and ghost ileostomy (GI) creation. Methods. Patients who underwent AR were stratified based on the risk to develop AL. Steps to avoid PI were splenic flexure mobilization, reduced pelvic bleeding, to employ different stapler charge if neoadjuvant chemo-radiotherapy is performed, to perform a horizontal section of the rectum, to evaluate the anastomotic vascularization with a fluorescence angiography, to perform a side-to-end anastomosis, intraoperative methylene blue test, pelvic and transanal drainage tubes placement, and the GI creation. After surgery, inflammatory blood markers were monitored to detect potential leakages. Results. Twelve patients were included. In one case, the specimen proximal section was changed after fluorescence angiography. There were no conversions in this group of patients. One postoperative AL occurred and was treated with radiological drainage placement, not being necessary to convert the GI. PI was avoided in 100% of cases. Conclusions. Patients’ characteristics cannot be changed, but several steps were used to avoid routine PI creation. The present protocol could be a valuable option to avoid PI in selected patients. Further studies with a wider sample size, and defined criteria to stratify the patients based on the risk to develop AL, are required.
Impact of Nasal Irrigation With Iodized Table Salt Solution on Mucociliary Clearance: Proof-of-Concept Randomized Control Trial
Authors: Sumaily Ibrahim , Alarifi Ibrahim , Alsuwaidan Raseel , Alsiwat Lojain , Alsaleh Saad
Published: December 2019

Introduction

Saline nasal irrigation is a common recommendation shared between the majority of clinical guidelines for sinusitis and rhinitis in adults and children. Studies involving homemade saline have typically involved the use of noniodized salt. However, the literature does not contain any descriptions for the use of iodized table salt in homemade saline solutions.

Objectives

To study the usefulness of iodized salt in homemade saline and its impact on mucociliary clearance (MCC).

Methods

Only healthy volunteers were enrolled in this randomized controlled trial. The sinonasal outcome test (SNOT)-22 and rhinoscopy were used to rule out any clinical evidence of sinusitis or rhinitis in the enrolled subjects. The saccharine clearance time (SCT) was used to evaluate MCC at baseline. Each candidate received 2 different nasal wash solutions—one containing iodized salt and the other containing noniodized salt—on different days. Visual analog scale pain scores were recorded while using each type of nasal wash. The SCT was assessed after each wash.

Results

Thirty-eight healthy candidates (18 men and 20 women) were enrolled in the study. All subjects were in their 30s. The mean baseline SCT was 10.92 minutes. The use of the noniodized salt solution led to a nonsignificant change ( P = .139) in mean SCT (9.68 min). In contrast, a significant change ( P = .035) was observed in mean SCT after the use of the iodized salt solution (9.06 min). However, the mean postirrigation SCT was not significantly different between solutions ( P = .31). No significant differences were observed in pain/discomfort experience between solutions.

Conclusion

MCC improved with both solutions. Interestingly, the improvement was significant, when the iodized salt nasal irrigation solution was used. This finding contradicts the conventional recommendation against the use of iodized salt in nasal rinse solution. Moreover, this solution was well tolerated. Further studies regarding the long-term safety are recommended.
Non-linear is not superior to linear aerobic training periodization in coronary heart disease patients
Authors: Boidin Maxime , Trachsel Lukas-Daniel , Nigam Anil , Juneau Martin , Tremblay Jonathan , Gayda Mathieu
Published: December 2019

Background

We aimed to compare: (1) two different periodized aerobic training protocols (linear (LP) versus non-linear (NLP)) on the cardiopulmonary exercise response in patients with coronary heart disease; (2) the proportion of responders between both training protocols.

Design

A randomized controlled trial.

Methods

A total of 39 coronary heart disease patients completed either LP ( n = 20, 65 ± 10 years) or NLP ( n = 19, 66 ± 5 years). All patients completed a cardiopulmonary exercise testing with gas exchange measurements. Patients underwent a 12-week supervised exercise program including an isoenergetic aerobic periodized training and a similar resistance training program, 3 times/week. Weekly energy expenditure was constantly increased in the LP group for the aerobic training, while it was deeply increased and intercepted with a recovery week each fourth week in the NLP group. Peak oxygen uptake (peak V̇O2), oxygen uptake efficiency slope, ventilatory efficiency slope (V̇E/V̇CO2 slope), V̇O2 at the first (VT1) and second (VT2) ventilatory thresholds, and oxygen pulse (O2 pulse) were measured. Responders were determined according the median value of the Δpeak V̇O2 (mL.min−1.kg−1).

Results

We found similar improvement for peak V̇O2 (LP: +8.1%, NLP: +5.3%, interaction: p = 0.37; time: p < 0.001) and for oxygen uptake efficiency slope, VT1, VT2 and O2 pulse in both groups (interaction: p > 0.05; time: p < 0.05) with a greater effect size in the LP group. The proportion of non-, low and high responders was similar between groups ( p = 0.29).

Conclusion

In contrast to the athletes, more variation (NLP) does not seem necessary for greater cardiopulmonary adaptations in coronary heart disease patients.
Finding a durable solution to Bangladesh’s Rohingya refugee problem: Policies, prospects and politics
Authors: Rashid Syeda Rozana
Published: December 2019

The article examines the traditional durable solutions to resolving the problem of the Rohingyas who crossed the Myanmar border during 2017–2018 and took refuge in Bangladesh. The article analyses the attitudes and behaviour of displaced Rohingyas and of Bangladesh, Myanmar and traditional settlement countries, as well as the hidden forces, including ethnoreligious factors, geo-strategic factors and public opinion, which impact the Rohingyas. It argues that finding durable solutions through repatriation, integration or resettlement of Rohingya refugees in their home, host and third countries respectively is almost unachievable. In line with the recent conceptualization of durable solutions by academics and practitioners, a context-specific solution is recommended for Rohingyas, combining national restoration of their civil and political rights in Myanmar, political and economic burden-sharing by prosperous countries and capacity-building of refugees to influence their own futures.
Protecting Outdoor Workers From Hazards Associated With Wildfire Smoke
Authors: Postma Julie
Published: December 2019

Wildfires are increasing in frequency and intensity, which increases outdoor workers’ risk of breathing smoke for sustained periods. Occupational health nurses have multiple roles to play to protect outdoor workers from the new “smoke season.”
Who Becomes a Business Owner in High-inequality Regimes? The Conditioning Effect of Economic Inequality on the Impact of Individual Educational and Financial Endowment on Entrepreneurship
Authors: Auguste Daniel
Published: December 2019

Research has shown that individual educational and financial endowments are key indicators of their potential for entrepreneurial entry and success. At the same time, scholars have shown that economic inequality undermines educational development while increasing financial precarity. Yet, we know little about the extent to which economic inequality may condition how education and income affect an individual’s entrepreneurial experience. In this article, we present a mixed-effect analysis using data from 50 countries that shows that economic inequality diminishes the importance of an individual’s education and income on entrepreneurial entry. This effect is larger for higher education and income individuals than those in the bottom of the educational and income strata. In addition, inequality increases the likelihood that an individual would undertake entrepreneurial activities as a last resort, particularly individuals in low-education strata. These results suggest that under high-inequality regimes, entrepreneurship may be a sign of economic insecurity and inefficiency, and highlight the need for scholars to pay greater attention to understanding the structural forces that facilitate entrepreneurship development.
Swept-Tone Stimulus-Frequency Otoacoustic Emissions in Human Newborns
Authors: Abdala Carolina , Luo Ping , Guardia Yeini
Published: December 2019

Several types of otoacoustic emissions have been characterized in newborns to study the maturational status of the cochlea at birth and to develop effective tests of hearing. The stimulus-frequency otoacoustic emission (SFOAE), a reflection-type emission elicited with a single low-level pure tone, is the least studied of these emissions and has not been comprehensively characterized in human newborns. The SFOAE has been linked to cochlear tuning and is sensitive to disruptions in cochlear gain (i.e., hearing loss) in adult subjects. In this study, we characterize SFOAEs evoked with rapidly sweeping tones in human neonates and consider the implications of our findings for human cochlear maturation. SFOAEs were measured in 29 term newborns within 72 hr of birth using swept tones presented at 2 oct/s across a four-octave frequency range (0.5–8 kHz); 20 normal-hearing young adults served as a control group. The prevalence of SFOAEs in newborns was as high as 90% (depending on how response “presence” was defined). Evidence of probe-tip leakage and abnormal ear-canal energy reflectance was observed in those ears with absent or unmeasurable SFOAEs. Results in the group of newborns with present stimulus-frequency emissions indicate that neonatal swept-tone SFOAEs are adult-like in morphology but have slightly higher amplitude compared with adults and longer SFOAE group delays. The origin of these nonadult-like features is probably mixed, including contributions from both conductive (ear canal and middle ear) and cochlear immaturities.
Creole becoming and the commons: Black freedom in Belize
Authors: Johnson Melissa
Published: December 2019

In rural Belize, Afro-Caribbean people have been generating economies and ecologies that simultaneously articulate with and are other than the global capitalism that initially brought enslaved West Africans and free Northern Europeans to the shores of Central America in the 1700s. What it is to be Belizean Creole initially emerged in the crucible of forest slavery and racial capitalism, but flourished in the generation of reciprocal economies and relational entanglement with the more than human, as blackness associated with freedom in the “bush.” Living in lands that did not interest Belize’s 19th century forestocracy, and that were not desirable for industrial agriculture, rural Creole people created commons for hunting, fishing, and other more than human engagement. The sense of being rural Creole develops from these entanglements and reciprocal relations that assemble with blackness and brownness in ways that are not fully contained within global white supremacist logics. This basis for a rural Creole identity has persisted even as rural Creole people engage today with the global capitalist projects of conservation and tourism, and as they live in transnational diaspora. In these ways, rural Creole people expand human being beyond the over-represented form of Man, as Sylvia Wynter has described the problem of the coloniality of “the human,” into a genre of “human being in common.” This expansion illustrates how commoning creates possibilities for blackness and brownness to thrive.
COPD treatment choices based on blood eosinophils: are we there yet?
Authors: Oliver Brian , Tonga Katrina , Darley David , Rutting Sandra , Zhang Xin , Chen Hui , Wang Gang
Published: December 2019

Eosinophils are increasingly being recognised as an important characteristic feature of COPD. Patients with COPD and eosinophilic inflammation tend to respond to steroid therapy; however, many questions remain regarding the optimum measurement. Eosinophilic inflammation may be defined based on various sampling techniques, including eosinophil levels in blood, sputum, bronchoalveolar lavage or biopsy, which leads to inconsistencies in its definition. Blood eosinophils may increase in conjunction with sputum eosinophils during COPD exacerbations and therefore may be a good surrogate marker of airway eosinophilic inflammation. However, the timing of the blood eosinophil measurement, the stability of the eosinophil count and the threshold used in different studies are variable. The use of blood eosinophil count to direct biological therapies in COPD has also had variable outcomes. Eosinophilic inflammation has an important role in COPD management; however, its use as the optimum biomarker still needs further investigation.

Key points

Eosinophilia may play a significant role in the pathogenesis of COPD.

Eosinophilic inflammation in COPD can be steroid responsive; however, eosinophilic inflammation is variable, and caution needs to be taken with measurements and the thresholds used.

The long-term effects of reducing eosinophil levels in COPD is unclear.

Educational aims

To explore current knowledge of eosinophils in COPD.

To explore the relationship between eosinophilia and corticosteroid use.

To understand the limitations of assessing and using eosinophilia in COPD.
A comparative study of the microstructure and water permeability between flattened bamboo and bamboo culm
Authors: Chen Hong , Zhang Yutian , Yang Xue , Ji Han , Zhong Tuhua , Wang Ge
Published: December 2019

The objective of this study is to investigate the microstructure, water permeability and the adhesion of waterborne coating on the flattened bamboo. The flattened bamboo was obtained by softening bamboo culm at 180 °C followed by compression. The microstructure and chemical component of flattened bamboo were investigated by scanning electron microscopy, Fourier transforms infrared spectroscopy, and X-ray diffraction. The adhesion and interface structure of waterborne coating onto flattened bamboo surface were also examined. The result indicated that the parenchyma cells in flattened bamboo were compressed, and starch in the parenchyma cell was extracted during the softening and flattening process in which the main chemical component did not change significantly. The water permeability of both flattened bamboo and bamboo culm is dependent on the direction: longitudinal direction > tangential direction > radial direction. However, the water permeability in all three directions in flattened bamboo was higher than those in the untreated bamboo. In addition, alkali dye solution was found to more easily permeate through the flattened bamboo when compared to acid dye solution, and the permeability varied depending on alkali dye or acid dye concentration. The adhesion of water-based polyurethane coating on the flattened bamboo can reach the second level.
Investigation of Band Alignment for Hybrid 2D-MoS2/3D-β-Ga2O3 Heterojunctions with Nitridation
Authors: Huan Ya-Wei , Xu Ke , Liu Wen-Jun , Zhang Hao , Golosov Dmitriy Anatolyevich , Xia Chang-Tai , Yu Hong-Yu , Wu Xiao-Han , Sun Qing-Qing , Ding Shi-Jin
Published: December 2019

Hybrid heterojunctions based on two-dimensional (2D) and conventional three-dimensional (3D) materials provide a promising way toward nanoelectronic devices with engineered features. In this work, we investigated the band alignment of a mixed-dimensional heterojunction composed of transferred MoS2 on β-Ga2O3($$ 2- $$2-01) with and without nitridation. The conduction and valence band offsets for unnitrided 2D-MoS2/3D-β-Ga2O3 heterojunction were determined to be respectively 0.43 ± 0.1 and 2.87 ± 0.1 eV. For the nitrided heterojunction, the conduction and valence band offsets were deduced to 0.68 ± 0.1 and 2.62 ± 0.1 eV, respectively. The modified band alignment could result from the dipole formed by charge transfer across the heterojunction interface. The effect of nitridation on the band alignments between group III oxides and transition metal dichalcogenides will supply feasible technical routes for designing their heterojunction-based electronic and optoelectronic devices.
Development of a 1550-nm InAs/GaAs Quantum Dot Saturable Absorber Mirror with a Short-Period Superlattice Capping Structure Towards Femtosecond Fiber Laser Applications
Authors: Jiang Cheng , Ning Jiqiang , Li Xiaohui , Wang Xu , Zhang Ziyang
Published: December 2019

Low-dimensional III–V InAs/GaAs quantum dots (QDs) have been successfully applied to semiconductor saturable absorber mirrors (SESAMs) working at a 900–1310-nm wavelength range for ultrafast pulsed laser applications benefitting from their broad bandwidth, wavelength flexibility, and low saturation fluence. However, it is very challenging to obtain a high-performance QD-SESAM working at the longer wavelength range around 1550 nm due to the huge obstacle to epitaxy growth of the QD structures. In this work, for the first time, it is revealed that, the InAs/GaAs QD system designed for the 1550-nm light emission range, the very weak carrier relaxation process from the capping layers (CLs) to QDs is mainly responsible for the poor emission performance, according to which we have developed a short-period superlattice (In0.20Ga0.80As/In0.30Ga0.70As)5 as the CL for the QDs and has realized ~ 10 times stronger emission at 1550 nm compared with the conventional InGaAs CL. Based on the developed QD structure, high-performance QD-SESAMs have been successfully achieved, exhibiting a very small saturation intensity of 13.7 MW/cm2 and a large nonlinear modulation depth of 1.6 %, simultaneously, which enables the construction of a 1550-nm femtosecond mode-locked fiber lasers with excellent long-term working stability.
ZIF-67-Derived CoSe/NC Composites as Anode Materials for Lithium-Ion Batteries
Authors: Li Zongyang , Zhang Lian Ying , Zhang Lei , Huang Jiamu , Liu Hongdong
Published: December 2019

As a typical metal selenide, CoSe is a kind of foreground anode material for lithium-ion batteries (LIBs) because of its two-dimensional layer structure, good electrical conductivity, and high theoretical capacity. In this work, the original CoSe/N-doped carbon (CoSe/NC) composites were synthesized using ZIF-67 as a precursor, in which the CoSe nanoparticles are encapsulated in NC nanolayers and they are connected through C–Se bonds. The coating structure and strong chemical coupling make the NC nanolayers could better effectively enhance the lithium storage properties of CoSe/NC composites. As a consequence, the CoSe/NC composites deliver a reversible capacity of 310.11 mAh g−1 after 500 cycles at 1.0 A g−1. Besides, the CoSe/NC composites show a distinct incremental behavior of capacity.
Identification of genes for salt tolerance and yield-related traits in rice plants grown hydroponically and under saline field conditions by genome-wide association study
Authors: Liu Chen , Chen Kai , Zhao Xiuqin , Wang Xiaoqian , Shen Congcong , Zhu Yajun , Dai Mingli , Qiu Xianjin , Yang Rongwei , Xing Danying , Pang Yunlong , Xu Jianlong
Published: December 2019

Background

Soil salinity is one of the main environmental conditions that affects rice production. Identifying the genetic loci that affect rice salt tolerance (ST)-related traits at the seedling stage, especially under saline field conditions, is crucial for ST rice breeding by pyramiding ST genes that act at different developmental stages.

Results

Large phenotypic variations were observed in 708 rice accessions, and yield and its related traits were considerably limited when exposed to salt stress. In a genome-wide association study (GWAS), 2255 marker-trait association signals were detected for all measured traits, and the significant SNPs were distributed in 903 genes. Of these, 43 genes processed same functional annotation, and the gene ontology terms “biological processes” and “molecular function” with the known genes responsive to salt stress in rice. Further haplotype analysis detected 15 promising candidates significantly associated with the target traits, including five known genes and 10 novel genes. We identified seven accessions carrying favorable haplotypes of four genes significantly associated with grain yield that performed well under saline stress conditions.

Conclusions

Using high density SNPs within genes to conduct GWAS is an effective way to identify candidate genes for salt tolerance in rice. Five known genes (OsMYB6, OsGAMYB, OsHKT1;4, OsCTR3, and OsSUT1) and two newly identified genes (LOC_Os02g49700, LOC_Os03g28300) significantly associated with grain yield and its related traits under saline stress conditions were identified. These promising candidates provide valuable resources for validating potential ST-related genes and will facilitate rice breeding for salt tolerance through marker-assisted selection.
Cell-Wide Survey of Amide-Bonded Lysine Modifications by Using Deacetylase CobB
Authors: Wei Yun , Yang Wan-Jie , Wang Qi-Jun , Lin Peng-Cheng , Zhao Jian-Yuan , Xu Wei , Zhao Shi-Min , He Xia-Di
Published: December 2019

Background

Lysine post-translational modifications are important regulators of protein function. Proteomic and biochemical approaches have resulted in identification of several lysine modifications, including acetylation, crotonylation, and succinylation. Here, we developed an approach for surveying amide-bonded lysine modifications in the proteome of human tissues/cells based on the observation that many lysine modifications are amide-bonded and that theSalmonella entericadeacetylase, CobB, is an amidase.

Results

After the proteome of human tissues/cells was denatured and the non-covalently bonded metabolites were removed by acetone washes, and the amide-bonded modifiers were released by CobB and analyzed using liquid- and/or gas chromatography/mass spectrometry metabolomic analysis. This protocol, which required 3–4 days for completion, was used to qualitatively identify more than 40 documented and unreported lysine modifications from the human proteome and to quantitatively analyze dynamic changes in targeted amide-bonded lysine modifications.

Conclusions

We developed a method that was capable of monitoring and quantifying amide-bonded lysine modifications in cells of different origins.
A hybrid deep learning framework for bacterial named entity recognition with domain features
Authors: Li Xusheng , Fu Chengcheng , Zhong Ran , Zhong Duo , He Tingting , Jiang Xingpeng
Published: December 2019

Background

Microbes have been shown to play a crucial role in various ecosystems. Many human diseases have been proved to be associated with bacteria, so it is essential to extract the interaction between bacteria for medical research and application. At the same time, many bacterial interactions with certain experimental evidences have been reported in biomedical literature. Integrating this knowledge into a database or knowledge graph could accelerate the progress of biomedical research. A crucial and necessary step in interaction extraction (IE) is named entity recognition (NER). However, due to the specificity of bacterial naming, there are still challenges in bacterial named entity recognition.

Results

In this paper, we propose a novel method for bacterial named entity recognition, which integrates domain features into a deep learning framework combining bidirectional long short-term memory network and convolutional neural network. When domain features are not added, F1-measure of the model achieves 89.14%. After part-of-speech (POS) features and dictionary features are added, F1-measure of the model achieves 89.7%. Hence, our model achieves an advanced performance in bacterial NER with the domain features.

Conclusions

We propose an efficient method for bacterial named entity recognition which combines domain features and deep learning models. Compared with the previous methods, the effect of our model has been improved. At the same time, the process of complex manual extraction and feature design are significantly reduced.
Multimodal deep representation learning for protein interaction identification and protein family classification
Authors: Zhang Da , Kabuka Mansur
Published: December 2019

Background

Protein-protein interactions(PPIs) engage in dynamic pathological and biological procedures constantly in our life. Thus, it is crucial to comprehend the PPIs thoroughly such that we are able to illuminate the disease occurrence, achieve the optimal drug-target therapeutic effect and describe the protein complex structures. However, compared to the protein sequences obtainable from various species and organisms, the number of revealed protein-protein interactions is relatively limited. To address this dilemma, lots of research endeavor have investigated in it to facilitate the discovery of novel PPIs. Among these methods, PPI prediction techniques that merely rely on protein sequence data are more widespread than other methods which require extensive biological domain knowledge.

Results

In this paper, we propose a multi-modal deep representation learning structure by incorporating protein physicochemical features with the graph topological features from the PPI networks. Specifically, our method not only bears in mind the protein sequence information but also discerns the topological representations for each protein node in the PPI networks. In our paper, we construct a stacked auto-encoder architecture together with a continuous bag-of-words (CBOW) model based on generated metapaths to study the PPI predictions. Following by that, we utilize the supervised deep neural networks to identify the PPIs and classify the protein families. The PPI prediction accuracy for eight species ranged from 96.76% to 99.77%, which signifies that our multi-modal deep representation learning framework achieves superior performance compared to other computational methods.

Conclusion

To the best of our knowledge, this is the first multi-modal deep representation learning framework for examining the PPI networks.
Virtual Grid Engine: a simulated grid engine environment for large-scale supercomputers
Authors: Ito Satoshi , Yadome Masaaki , Nishiki Tatsuo , Ishiduki Shigeru , Inoue Hikaru , Yamaguchi Rui , Miyano Satoru
Published: December 2019

Background

Supercomputers have become indispensable infrastructures in science and industries. In particular, most state-of-the-art scientific results utilize massively parallel supercomputers ranked in TOP500. However, their use is still limited in the bioinformatics field due to the fundamental fact that the asynchronous parallel processing service of Grid Engine is not provided on them. To encourage the use of massively parallel supercomputers in bioinformatics, we developed middleware called Virtual Grid Engine, which enables software pipelines to automatically perform their tasks as MPI programs.

Result

We conducted basic tests to check the time required to assign jobs to workers by VGE. The results showed that the overhead of the employed algorithm was 246 microseconds and our software can manage thousands of jobs smoothly on the K computer. We also tried a practical test in the bioinformatics field. This test included two tasks, the split and BWA alignment of input FASTQ data. 25,055 nodes (2,000,440 cores) were used for this calculation and accomplished it in three hours.

Conclusion

We considered that there were four important requirements for this kind of software, non-privilege server program, multiple job handling, dependency control, and usability. We carefully designed and checked all requirements. And this software fulfilled all the requirements and achieved good performance in a large scale analysis.
Association of household secondhand smoke exposure and mortality risk in patients with heart failure
Authors: He Xin , Zhao Jingjing , He Jiangui , Dong Yugang , Liu Chen
Published: December 2019

Background

Secondhand smoke (SHS) exposure is a well-established cardiovascular risk factor, yet association between SHS and prognosis of heart failure remains uncertain.

Method

Data were obtained from the US National Health and Nutrition Examination Surveys III from 1988 to 1994. Currently nonsmoking adults with a self-reported history of heart failure were included. Household SHS exposure was assessed by questionnaire. Participants were followed up through December 31, 2011. Cox proportional-hazards models were used to assess the association of household SHS exposure and mortality risk. Potential confounding factors were adjusted.

Results

Of 572 currently nonsmoking patients with heart failure, 88 were exposed to household SHS while 484 were not. There were totally 475 deaths during follow-up. In univariate analysis, household SHS was not associated with mortality risk (hazard ratio [HR]: 0.98, 95% confidence interval [CI]: 0.76–1.26, p = 0.864). However, after adjustment for demographic variables, socioeconomic variables and medication, heart failure patients in exposed group had a 43% increase of mortality risk compared with those in unexposed group (HR: 1.43, 95% CI: 1.10–1.86, p = 0.007). Analysis with further adjustment for general health status and comorbidities yielded similar result (HR: 1.47, 95% CI: 1.13–1.92, p = 0.005).

Conclusion

Household SHS exposure was associated with increased mortality risk in heart failure patients.
Detecting delirium in patients with acute stroke: a systematic review of test accuracy
Authors: Mansutti Irene , Saiani Luisa , Palese Alvisa
Published: December 2019

Background

Patients with acute stroke are particularly vulnerable to delirium episodes. Although delirium detection is important, no evidence-based recommendations have been established to date on how these patients should be routinely screened for delirium or which tool should be used for this purpose in this population. Therefore, the aim of this study was to identify delirium screening tools for patients with acute stroke and to summarise their accuracy.

Methods

Following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines, a systematic search of Medline, CINAHL and Scopus databases was performed to include: (a) diagnostic test accuracy studies; (b) evaluating tools detecting delirium among patients with acute stroke; (c) written in English; (d) published up to September 2018. The included studies were assessed in their quality by using the Quality Assessment of Diagnostic Accuracy Studies-2.

Results

A total of four studies have been performed to date in the field with a variable quality for the methodology used and documentation of the accuracy of mainly two tools, as (1) the 4-Assessment Test for delirium (4AT), reporting a range of sensitivity from 90.2 to 100% and a specificity from 64.5 to 86%; and (2) the Confusion Assessment Method-Intensive Care Unit (CAM-ICU) showing a sensitivity of 76% (95% Confidence of Interval [CI] 55–91) and a specificity of 98% (95%CI 93–100). Other tools have been studied as: The Abbreviated Mental Test-10, the Abbreviated Mental Test short form, the Clock Drawing Test, the Cognitive Examination derived from the National Institutes of Health Stroke Scale and the Glasgow Coma Scale. Moreover, the use of a single question—namely, ‘Does this patient have cognitive issues?’ as answered by the multidisciplinary team—has been subjected to a validation process.

Conclusions

To date a few primary studies have been published to test the accuracy of tools in their ability to detect post-stroke delirium; among those available, the 4AT and the CAM-ICU tools have been mostly studied. Research has just started to add evidence to the challenge of detecting and usefully assessing newly-acquired delirium among stroke patients: therefore, more studies are needed to improve the knowledge and allow a robust selection of the most useful tool to use in this population.