bluuebunny/crossref_metadata_2025 huggingface dataset:
Transformation of structural-phase states in rail head at extremely long-term operation
Authors: Kuznetsov R. V. , Kormyshev V. E. , Gromov V. E. , Ivanov Yu. F. , Shlyarova Yu. A.
Published: April 2022

Quantitative transformations of the structure at a depth of 0, 2, 5, 10 mm along the central and symmetry axis of the fillet of long differentially quenched rails head after extremely long-term operation (passed tonnage of 1770 mln. gross tons) were identified at macro-, micro- and nanoscale levels by methods of optical, scanning and transmission electron diffraction microscopy. At a macroscale level, the numerous shallow parallel cracks of contact fatigue are detected on the surface of working fillet, and on the surface of inoperative fillet there are only small spallings. The lateral wear of the rail was 2.5 mm and the vertical wear was 2 mm. Microstructure of the rail head metal corresponds to the requirements of standards and specifications of the Russian Railways. At microscale level, the transformation of cementite plates was established by cutting it with moving dislocations and dissolving with the escape of carbon to the dislocation lines, low- and high-angle boundaries. A decrease in microstructure dispersion is noted with a distance from the tread surface. At the nanoscale level, subgrain structure formed in the surface layers (subgrain size 110 – 200 μm) contains nanosized cementite particles (25 – 60 nm) localized at the joints and along the subgrain boundaries. It is supposed that this type of structure is formed as a result of dynamic recrystallization under megaplastic deformation in the process of extremely long-term operation of rails. The content of subgrain structure in the fillet layer is five-fold higher than that in surface layer of the tread surface. It was established that during operation, the transformation of lamellar perlite along the central axis of the head proceeds more slowly than along the symmetry axis of the fillet.
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Authors: Prime Diet Keto
Published: April 2022

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[RETRACTED] NovoFit Keto Pills Reviews - Is Novo Fit Keto Legitimate or Scam? v1
Authors: not provided novofitketopillsreviews
Published: April 2022

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[RETRACTED] Spartan Testo Boost Pro (Urgent 2022 Update) Risky Side Effects Complaints? v1
Authors: not provided spartan
Published: April 2022

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[RETRACTED] Releaf CBD Gummies Canada - Reviews & Shark Tank v1
Authors: not provided releafgummiescanada
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Authors: not provided SpartanTesto
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Authors: Prime Diet Keto
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[RETRACTED] customer Alert!Spartan Testo Boost Pro v1
Authors: not provided spartan
Published: April 2022

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Authors: not provided naturespureketreviews
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[RETRACTED] Slim-Mediq-Keto-Gummies-Reviews - Popular Weight Loss Gummies! v1
Authors: Mediq Keto Gummies Slim
Published: April 2022

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Defensive strategy optimization of consecutive-k-out-of-n systems under deterministic external risks
Authors: Zhao Jiangbin , Zhang Zaoyan , Xu Tianbo , Cao Xiangang , Wang Qiyu , Cai Zhiqiang
Published: April 2022

Consecutive-k-out-of-n (Con/k/n) system, a reconfigurable system, can improve the system performance by adjusting the redundancy and assignment of components. This paper aims to determine the optimal defensive strategy of Con/k/n systems under external risks. The defensive capability of Con/k/n systems is evaluated based on real-time system reliability, and a defensive importance measure (DIM) is constructed to optimize components’ redundancy locally. To solve the proposed optimization model effectively, a DIM-based genetic algorithm (DIGA) is developed by integrating the advantages of DIM’s local search with the global search ability of the classical genetic algorithm (CGA). The numerical experiment under 36 scenarios illustrates that DIGA is more effective than CGA verified by average defensive capability, robustness, and convergence generations. Moreover, the redundancy distribution analysis of Con/k/5 systems in the optimal defensive strategy shows that the redundancy of F(G) systems is in a spaced (continuous) way under spacing k-1 risk or continuous k risk.
Parental violence before, during and after COVID-19 lockdown
Authors: Barroso Ricardo , Ramião Eduarda , Figueiredo Patrícia
Published: April 2022

It’s not clear if and how social distancing measures to control COVID-19 transmission may result in more occurrences of child and adolescent abuse perpetrated by their parents. Information often comes from indirect estimates and media reports. More evidence is needed from multiple sources, particularly from the potential victims. The aim of this study was to compare the proportion of violence perpetrated on adolescents by their parents before, during and after the COVID-19 lockdown in Portugal. Three different samples with adolescents aged 12–18 years were collected before (n = 1444), during (n = 1427) and after (n = 794) the lockdown and compared to verify variations concerning parental violence behaviors. Higher rates of aggressive parental behavior were found, but results showed that adolescents reported a reduction of psychological, physical, and sexual violence perpetrated by their parents during and after the COVID-19 lockdown. Implications and future research needs are discussed.
Aliança de trabalho em aconselhamento de carreira: Fatores dos/as psicólogos/as e clientes
Authors: Taveira Maria do Céu , Cardoso Paulo , Pereira Soraia , Silva Filipa
Published: April 2022

A aliança de trabalho é um preditor da eficácia da intervenção psicológica e envolve o trabalho colaborativo entre psicólogo/a e cliente. Neste estudo, analisa-se em que medida a experiência profissional dos/as psicólogos/as, o rendimento económico e a (in)decisão do/da cliente predizem a aliança de trabalho inicial e se esses fatores e a aliança inicial predizem a aliança final. Participaram 49 clientes do aconselhamento de construção da carreira, com idade entre os 17 e os 52 anos e sete psicólogas. Utilizou-se um questionário sociodemográfico, a Escala de Decisão de Carreira e o Inventário da Aliança Terapêutica. Resultados de análises de regressão linear múltipla indicam a experiência profissional dos/as psicólogos/as e o rendimento económico dos/as clientes como preditores da aliança inicial. A experiência profissional dos/as psicólogos/as, a indecisão final dos/as clientes e a aliança inicial predizem a aliança final. Os resultados deste estudo são discutidos, retirando-se implicações para a investigação e prática.
Knowledge about Autism Spectrum Disorder (ASD) Predicts Motivation to Volunteer: A Cross-Sectional Survey among Psychology Students
Authors: JOMINOL JOCELYN DEANA , SIN SIAU CHING , RABBANI MOHTARAM , ZAINI MIMI FITRIANA , AMINI MANSOUR , YAHYA AMIRA NAJIHA , NI TEE JING , ABDUL AZIZ MUHAMAD NUR FARIDUDDIN
Published: April 2022

Children with Autism Spectrum Disorder (ASD) and their parents require support from the community, and could profit from volunteer work involving the family. At the same time, university students demonstrate a high willingness to volunteer in community initiatives such as work involving children with ASD. This study aims to examine the relationship between ASD knowledge and the motivation to volunteer among university students. Students (N=150) from a private university in the Klang Valley, Malaysia, participated in this study. Instruments utilized in this study were the Stone Autism Survey and Volunteer Functions Inventory. The results indicated that a higher level of ASD knowledge was the strongest predictor of higher motivation to volunteer after adjusting for relevant demographic factors and exposure to ASD children. Meanwhile, female and Hindu participants reported a significantly higher motivation to volunteer. This study emphasizes the need to increase factual knowledge about ASD among university students, and any effort to encourage students to volunteer in helping individuals with ASD should include knowledge sharing about this population.
Effects of Layered Clothing on the Post-mortem Decomposition of Rat Carcasses on Grass Bushes and Dead Leaves
Authors: HAMZAH NOOR HAZFALINDA , MANIMARAN DARISHINI , OSMAN KHAIRUL , MD ISA NUR MAHIZA , GABRIEL GINA FRANCESCA
Published: April 2022

A post-mortem decomposition is defined by the evaluation of the physical and chemical changes of a cadaver or a carcass in order to estimate the cause of death and the time of death. The purpose of this study is not to replicate a real crime scene but to enhance knowledge of the effects of clothing in a decomposition process, mainly, the effects of layered cotton clothing on the post-mortem decomposition of adult female rat carcasses. Fifteen rats were divided into three groups: control, one-layered and two-layered clothed. The control subjects were unclothed and used to compare the post-mortem changes with the clothed subjects, one-layered and two-layered rat carcasses. All subjects were placed outdoor, 2.5 meters away from each other on grass bushes and dead leaves. Ambient temperature and humidity were recorded to observe if it associates with the post-mortem changes of the rats. Insect activity on each subject was observed. Post-mortem changes were measured using the Total Body Score system. The results showed that the control group underwent a faster decomposition compared to the clothed groups. The different layers of clothing did not show a vast difference in post-mortem changes. The ambient temperature of 28°C influences the post-mortem decomposition. The decomposition was rapid under the dominance of maggots compared to ants as ant colonies delayed the decomposition process. The study gave the knowledge of the effect of clothing in decomposition of female rats in forensic science.
sLORETA Source Localization in Dyslexic Children during Different Congruency of Visual Images: P300 Component Analysis
Authors: BEGUM TAHAMINA , ALI SITI ATIYAH , REZA FARUQUE , FADZIL NOR ASYIKIN , MUSTAFAR FAIZ
Published: April 2022

The question of whether dyslexic children have visual cognitive differences in terms of brain activity as compared to normal children remains unsolved. Here, we aimed to study the neuronal source activity during visual attentional processing reflected in the P300 Event-Related Potential (ERP) component, when being exposed to the different congruency of visual images on dyslexic children by utilizing an ERP. Twelve dyslexic and twelve non-dyslexic children in the range of age 8 to 11 years old took part in this study. They pressed button ‘1’ when they saw a congruence image of the animal in its natural habitat and button ‘2’ for incongruence animal images in non-natural habitat. The source localization of P300 was executed on the grand average waveform by utilising Standardised Low-Resolution Brain Electromagnetic Tomography (sLORETA) algorithm provided by Net Station software. The BA 19 of the left occipital lobe was the most activated during congruence and incongruence images in the dyslexic children. As for the control children, BA 18 and BA 17 of the occipital lobe were activated during congruence and incongruence images, respectively. In sum, there were no differences in source activity areas during both visual images in dyslexic children as compared to the control children, which brings us to a conclusion that the visual attentional activity in dyslexic children used the brain areas that are associated with visual characteristics rather than context differences. Keywords: Dyslexia; visual attention; event related potential; sLORETA; image congruency
Malaysian Herbs in Contraception: Public Perception
Authors: SHAHIDAN WAN NAZATUL SHIMA , TUAN ISMAIL TUAN NADRAH NAIM , PONNURAJ KANNAN THIRUMULU
Published: April 2022

Medicinal plants have been used in Malaysia for a long time ago. These plants have been marketed as herbal product and used in the traditional healthcare system because of its positive therapeutic effects. This paper discusses particularly several types of Malaysian herbs that are traditionally used for contraception and scientific studies related to its pharmaceutical properties showing its use among the public for its anti-fertility effects. Even though several methods of contraception have been promoted for family planning, yet, the perception of the public on the usage of synthetic steroidal contraceptives due to its serious adverse effects has made them focus on indigenous plants. Contraceptives drug-containing oestrogen and progesterone have proven to be effective and popular, However, the side effects of these drugs have sparked the idea of scientists to develop newer molecules from medicinal plants. Therefore, it is necessary to investigate in-depth qualitative research on conceptions and concerns about traditional contraceptive methods using herbal ingredients among Malaysians.
Video Modelling to Improve Hand Dexterity in Students with Learning Disabilities: Special Education Teachers' Perspectives
Authors: ABD AZIZ NURBIETA , KADAR MASNE , HARUN DZALANI , MOHD RASDI HANIF FARHAN
Published: April 2022

Proficient hand dexterity (HD) may help students with learning disabilities (LDs) perform various hand tasks efficiently. Video modelling (VM) is a strategy that uses a model to improve desired skills. However, the limited study focuses on VM to improve HD among students with LDs. Therefore, this study explores VM implementation in the learning and teaching process to improve the HD of students with LDs. Five Special Education (SE) teachers who taught the Hand Manipulative Component lessons in two different states were purposefully selected and invited to participate in this study. A one-toone interview was conducted with individual SE teachers. The interview sessions were audio-recorded and transcribed verbatim, and the data was analysed through thematic analysis. Rigorous approaches were performed to ensure the findings' trustworthiness, such as triangulation, member checking, and an audit trail. Four key themes emerged: conventional learning and teaching methods, challenges faced by students with LDs in improving HD, and the advantages of implementing VM in learning and teaching to improve HD and develop a video module. This study suggests SE teachers can implement VM in their learning and teaching processes to improve the HD performance of students with LDs. This current study concludes that VM can be a supportive strategy in the teaching process to improve HD performance among students with LDs.
Information technologies in the analysis of pharmaceutical personnel security
Authors: Klishchenko Marina  Y. , Kuznetsov Dmitriy
Published: April 2022

The implementation of the State Program "Development of the pharmaceutical and medical industry" is largely determined by the human resources of pharmaceutical organizations. In this regard, personnel are the most important element for organizations; the effectiveness of the organization, its development and success depend on their experience, abilities, competencies. Ensuring personnel security requires special attention at all stages of the organization's activities, which determines the need to study the factors and threats that have a special impact on it and, therefore, determines the relevance of this issue. The computer program "Pharmaceutical Personnel Security" developed by us was implemented in accordance with the national project "Healthcare", which identified the need for digitalization of the national system in order to improve the quality and effectiveness of pharmaceutical care. In this regard, we consider the introduction of the Pharmaceutical Personnel Security program into the activities of pharmaceutical industry organizations to automate the process of analyzing the state of personnel security relevant and promising
Processed meat consumption increases risk of type 2 diabetes mellitus in adults aged 40 years and older
Authors: Solikhah Solikhah , Lestari Asri
Published: April 2022

Background Type 2 diabetes mellitus (T2DM) remains a public health problem in the world, including Indonesia. The high mortality of T2DM is triggered by an unhealthy eating pattern and sedentary lifestyle. We aimed to investigate the relationship of food intake pattern and its related factors with T2DM in adults 40 years and older.
MethodsThis was a cross-sectional study conducted on 11,022 men and women with T2DM aged 40 years and older. Major dietary patterns were collected and multiple logistic regression analysis was used to determine the effect of covariates. Statistical significance was set at a p-value of <0.05.
ResultsMales and individuals aged >40 years comprised 50.17% and 26.19%, respectively, of the 11,022 respondents. Individuals aged over 50 years had a higher risk of developing diabetes than those aged less than 50 years (AOR =5.67, 95% CI=1.37-21.94, p<0.05). Dietary processed meat was associated with a higher risk of T2DM (AOR = 4.9; 95% CI=1.08-22.20, p<0.05). Carbohydrate and fruit intakes were negatively associated with and protective factors for DM (AOR= 0.01; 95% CI=0.01-0.06, p<0.01; AOR = 0.35; 95% CI=0.15-0.83, p<0.01). However, physical activity was not a risk factor for T2DM.
ConclusionsProcessed meat consumption, age over 50 years, and carbohydrate intake may increase the risk of T2DM in adults. Conversely, fruit intake may decrease the risk of T2DM in adults. There is a need to control the diet and lifestyle for the early prevention of DM.
High glycosylated hemoglobin level as a risk factor of latent tuberculosis infection in patients with uncomplicated type 2 diabetes mellitus
Authors: Arliny Yunita , Yanifitri Dewi Behtri , Mursalin Diennisa
Published: April 2022

Background Diabetes mellitus (DM) is known to increase the risk of infection including tuberculosis (TB). Some studies also showed that 2-15% of latent TB infection (LTBI) will progress to active TB. This study aimed to obtain the prevalence of LTBI and to determine the risk factors of LTBI in patients with type 2 diabetes mellitus (T2DM).
Methods This was a cross-sectional study on 242 adult T2DM patients. For LTBI screening we performed the interferon gamma release assay (IGRA) (Quantiferon TB Gold Plus test) and for confirmation of active TB (pulmonary TB) we performed GeneXpert MTB/Rif sputum examination and chest X-ray. Glycosylated hemoglobin (HbA1c) levels, smoking history and BCG scar were collected. Multivariate logistic regression was used to analyze the data.
Results Positive IGRA results were found in 99 of 242 uncomplicated T2DM patients while LTBI was found in 82 patients (33.8%). There were significant differences between T2DM patients with latent TB and T2DM patients without infection in HbA1c and specific IFN-ã levels (TB1 minus nil and TB2 minus nil), i.e. 8.5% and 7.6%, 2.5 IU/mL and 0.06 IU/mL, and 2.6 IU/mL and 0.08 IU/mL, respectively. Multivariate analysis showed that the risk factors for LTBI in T2DM patients were smoking history, HbA1c >7%, and no BCG scar.
Conclusions Because LTBI is prevalent in T2DM, it is important to screen for it in T2DM patients due to the risk of developing severe active TB. Absence of a BCG scar and high HbA1c levels are strong predictors of LTBI in T2DM patients.
Neutrophil-lymphocyte ratio and fournier gangrene severity index are not prognostic factors of mortality in fournier gangrene patients
Authors: Raizandha Muhammad Achdiar , Hidayatullah Furqan , Kloping Yudhistira Pradnyan , Rizaldi Fikri
Published: April 2022

Background Fournier gangrene (FG) is a life-threatening disease, commonly found in diabetic and immunocompromised patients. Recent studies suggested the use of new parameters apart from the commonly used Fournier gangrene severity index (FGSI), such as the neutrophil-lymphocyte ratio (NLR), the clinical use of which remains questionable. Therefore, we aimed to evaluate the role of the NLR and FGSI as a prognostic factor of mortality in patients with FG.
MethodsThis is an analytical study with a retrospective approach involving 109 adult patients diagnosed with FG. Data were collected regarding medical history, symptoms, physical examination findings, and laboratory tests. The FGSI score and NLR were determined. Bivariate analysis was performed using chi-square test and independent t-test. Overall survival between groups was compared using Kaplan–Meier survival estimates and Cox regression test.
ResultsOf the 109 patients, 90 survived (82.5%, group 1) and 19 died (17.43%, group 2). The cut-off point of NLR among the patients was 10.9, with a 73.7% sensitivity and 60% specificity. The area under curve value was 0.65 (95% CI; 0.524-0.754; p<0.05). The Kaplan Meier survival analysis showed that NLR was as an independent prognostic factor of mortality in FG patients (HR 5.177; 95% CI; 1.092-8.471; p<0.05), but Cox regression analysis showed that NLR and FGSI were not significant prognostic factors of mortality (p=0.09 and p=0.179; respectively).
ConclusionThis study demonstrated that NLR and FGSI are not important as prognostic tools for FG mortality.
Formulation development and evaluation of novel herbal toothpaste from natural source
Authors: Senthilkumar K.L. , Venkateswaran. S. , Vasanthan A. , Chiranjeevi P. , Mohamed N , Dinesh S. , Neshkumar. K.L.S.
Published: April 2022

Herbal toothpaste with natural ingredients is more acceptable in public opinion than chemical-based synthetic formulations in the current oral dental care scenario due to their safety and efficacy in reducing dental caries and preventing other dental disorders to which this generation is prone. In this composition, we use aloe Vera gel, clove oil, Neem powder, pomegranate peel powder, all of which have never been used before in any research. These extracts have anti-ulcer, anti-caries, anti-bacterial, and wound-healing properties, as well as certain unique properties including anti-cancer and anti-fungal. Herbal toothpastes were evaluated to determine important physical characteristics such as pH, stability, extrudability, spreadability, foamability, and homogeneity in order to develop a more effective and stable product. The purpose of this project is to make and test herbal toothpaste. This research proves that our herbal-based toothpaste formulation with natural ingredients is as excellent as it gets in terms of performance.
Quantitative estimation of sitagliptin and dapagliflozin propanediol monohydrate in synthetic mixture using 1 order derivative spectroscopy simultaneous spectrophotometric analysis
Authors: Jani Shivani , Shukla Rashmi , Patel Pinak , Mehta Binny , Detholia Krunal
Published: April 2022

Current research paper describes highly specific and reproducible 1 order derivative spectroscopic method for quantitative analysis of Sitagliptin which is a DPP4 inhibitors and Dapagliflozin which is SGLT2 inhibitors from its synthetic mixture. Both drugs are from Anti Diabetics class. Present analytical method was developed on Shimadzu double beam spectrophotometer equipped with UV probe 2.42 as software using methyl alcohol as solvent. Quantification of Sitagliptin was carried out at zero cross over point of Dapagliflozin that is 275 nm and for Dapagliflozin, it was achieved at 232 nm which is zero cross over point of Sitagliptin. Method shows linear response in the range of 25-125 µg/mL of Sitagliptin and 2.5-12.5 µg/mL of Dapagliflozin. Method was found to be accurate with recovery between 99.3 – 100.1 % for Sitagliptin and 98.2 – 100.7 % for Dapagliflozin. The developed method was validated as per ICH Q2 R1 guidelines and was successfully applied for quantitative analysis of synthetic mixture of Sitagliptin and Dapagliflozin.
(RE)pensando a Formação Docente: o que o Ensino Remoto Emergencial Diz sobre a Formação do professor?
Authors: Weber Dorcas Janice , Alves Elaine Jesus
Published: April 2022

O ensino remoto emergencial foi criado para adaptar as práticas da educação formal. Esta ação, entendida como provisória, desvelou movimentos e urgências que estão para além do contexto de pandemia do novo Coronavírus. Neste artigo, foi utilizada a metodologia de revisão sistemática de literatura para realizar um levantamento sobre os desafios apresentados no ensino emergencial remoto e traçar reflexões sobre as características necessárias nos docentes no mundo permeado pela cibercultura. Os resultados apontaram que os desafios enfrentados pelos docentes independem de nível de ensino: falta de formação para atuar com tecnologias; alunos apáticos e sem acesso à internet; docentes sobrecarregados com múltiplas atividades, são alguns deles. Conclui-se apontando a necessidade de uma formação docente que abarque distintas e novas competências e habilidades necessárias para sua atuação no contexto atual de ensino remoto e no ensino híbrido em um cenário pós-pandemia.

Palavras-chave: Formação docente. Tecnologias educativas. Ensino remoto.
Teoria artefaktu. W stronę krytyki ikoniczności dawnych Greków
Authors: Borowicz Sebastian
Published: April 2022

Teoria artefaktu jest rozwinięciem projektu krytyki ikoniczności autora zaprezentowanej w książce Reliefy rozmazane. Rzeczy i obrazy w kulturze dawnej Grecji (2020). Jej celem jest przemodelowanie zastanego myślenia o wytworach kultury greckiej okresu archaicznego i klasycznego w perspektywie kategorii obrazu uwikłanej w dyskurs filozoficzny, mającej tym samym niejasny i zmienny historycznie status. Proponowana w miejsce obrazu kategoria artefaktu obejmuje wszelkie wytwory plastyczne oraz zespolone z nimi działania, praktyki i gry społeczne oraz ich światopoglądowe motywacje. Artefakt jest więc rodzajem osadzonego społecznie dynamicznego bytu ikonicznego. Zapis z częściową kursywą ma pojęcie to odróżniać od artefaktu archeologicznego, rzeczy w jej czysto materialnym, fizycznym wymiarze. Kategoria artefaktu podkreśla również procesualny charakter percepcji rzeczy w kulturach dawnych, np. stawanie zamiast bycia. W myśl prezentowanej teorii naczynie, posąg czy malowidło ma nie tyle wymiar wizualny, ile performatywny i sprawczy; jest formą ingerencji w świat. Dynamika oglądu rzeczy była także uzależniona od otoczenia, co ujawnia się m.in. w odmiennym sposobie postrzegania artefaktów przez Homerowego Telemacha w pałacu Menelaosa i w pałacu Nestora. Różnice tę autor ujmuje w ramach dwu wyróżnionych typów kultury – chōros (χῶρος) oraz diakrisis (διάκρισις).

W drugiej części artykułu w ramach nastawienia krytycznego, poddany zostaje redefinicji status ikoniczności w kulturze archaicznej. Jest to strategia poznawcza mająca na celu ujawnienie oraz charakterystykę gier i praktyk społecznych stojących za właściwymi kulturze greckiej formami plastycznego zadysponowania. Ikoniczność w perspektywie krytycznej jest nie tyle efektem końcowym, rezultatem czegoś służącym celom estetycznym, ile jednym z działań składających się na to, czym jest dany posąg czy malowidło jako stan rzeczy (niem. Sachverhalt).
Legal Protect of the Deaf in International Documents and the Iranian Legal System
Authors: Ataee Afsaneh , Noori Valiollah , Pourkhaghan Zeinab
Published: April 2022

Background and Aim: This article seeks to examine rights of deaf and unable to hear individuals in international documents as well as domestic Iranian law. In this review, supports in the mentioned documents are discussed and the weaknesses, strengths, objections, and challenges in the laws are analyzed and examined. Lack of access to community facilities lead to marginalization of deaf people. Access to community facilities is an important factor that creates equal opportunities and realizes rights of deaf people.
Recent Findings: Iran’s accession to the Treaty on the Rights of disabled people, the Global treaty on Cultural, Public, Economic as well as Children’s title, is one of salient points of these protection laws. By implementing Iran’s national and global commitments regarding titles of the deaf, it is concluded that Comprehensive Law and its executive regulations have been adopted several years before accession to the Contract on the Disability, but they cover most of concepts of the Contract on Education.
Conclusion: Given the Senate and the convention, no significant legal action was taken and the program did not address deaf directly. The lack of an effective mechanism for laws protecting the disabled people right is an institutional as well as structural obstacle for realization of disabled people, especially deaf.
Keywords: Disability; hard of hearing; human rights; international law; low hearing loss
Medication Reconciliation at a Glance
Authors: Mohammadi Mehdi
Published: April 2022

The article's abstract is not available.
Challenges of Blood Transfusions in β-Thalassemia during COVID-19 Pandemic in Low Middle-Income Country
Authors: Ali Kashif , Rizvi Kashif , Ansari Saqib Hussain , Zahid Faisal
Published: April 2022

Wuhan, Hubei province, China, was recognized as the center of an epidemic of pneumonia of unknown origin in December 2019. Ultimately, intense focus on the disease was raised in China and globally. Consequently, on January 7, 2020, Chinese research scientists identified the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in an affected patient in Wuhan. Several members of this family circulate in humans, causing a wide range of disease conditions ranging from mild to life-threatening Beta thalassemia is a congenital hereditary disorder of inefficient erythropoiesis that leads to peripheral red cell breakdown due to defective β-globin series. The severity of the disease depends on multiple genetic and environmental factors. Individuals with beta-thalassemia are classified based on their transfusion demands as having transfusion-dependent thalassemia (TDT) or non-transfusion-dependent thalassemia (NTDT). Routine transfusion remains the recommended standard management for beta-thalassemia, as it efficiently controls the thalassemia symptoms. If left untreated, Beta thalassemia major (BTM) can eventually induce spleen enlargement, deformation of bone due to bone marrow growth, and heart failure due to severe anemia.
An Exploration of the Socioeconomic Benefits of Designating a Regional Park in the Severn Vale, UK
Authors: Cookes Katie Megan , Russo Alessio
Published: April 2022

This study used qualitative research methods and GIS to explore the potential social and economic benefits of creating a regional park in the Severn Vale, Gloucestershire, UK. We first explored where the park boundary could potentially lie by a series of stages of suitability mapping in GIS. Subsequently, a mini focus group and three semi-structured interviews were conducted with experts in relevant fields in order to obtain perceptions on what the socio-economic benefits could be of establishing a regional park. Perceptions and suggestions obtained from the data recommended how the regional park should incorporate addressing issues such as health inequalities, inclusivity of all segments of society, options for active and sustainable travel, community engagement, and the creation of a positive regional brand, into the managerial practices and design elements of the proposed Severn Vale Regional Park.
ВЛИЯНИЕ ТЕМПОВ ЭКОНОМИЧЕСКОГО РОСТА НА РЕАЛЬНЫЕ ДОХОДЫ НАСЕЛЕНИЯ И ИХ РАСПРЕДЕЛЕНИЕ В РОССИИ
Authors: Якимова Татьяна Борисовна
Published: April 2022

Имеющиеся диспропорции в оплате труда, низкие темпы роста доходов населения, их высокая дифференциация негативно сказываются на социально-экономическом развитии России, что и обуславливает актуальность данного исследования.  Цель работы – анализ влияния темпов экономического роста в России на динамику среднедушевых доходов населения и неравенство в их распределении. Методы исследования: методы анализа, синтеза, сравнения; метод статистического анализа является основным и основан на требованиях объективного и всестороннего анализа доходов населения. Результаты и выводы: проанализированы статистические данные с 2000 по 2020 г., показывающие усиление неравенства в распределении денежных доходов населения по стране в целом за анализируемый период. Статистически определена взаимосвязь между темпами экономического роста и уровнем дифференциации населения по доходам. Выделены причины данного процесса в России. При проведении анализа степени дифференциации набором показателей, среди которых основными выступили децильный коэффициент фондов и коэффициент Джини, было установлено, что экономический рост сам по себе не решает проблему экономического неравенства. За анализируемый период высокие темпы экономического роста в России сопровождались усилением дифференциации населения по доходам, что имеет свое обоснование. Также было выявлено, что реальные доходы населения растут, когда темпы экономического роста, выраженные в приросте реального ВВП, превышают три процента. При этом более ощутимое улучшение материального положения населения наблюдается при темпах роста реального ВВП свыше пяти процентов.
ПРЕДСТАВЛЕНИЕ ВОЛОНТЕРОВ О СЧАСТЬЕ
Authors: Сухарькова Марина Петровна
Published: April 2022

Статья посвящена олимпийским волонтерам – участникам одной из первых комплексных программ по работе с волонтерами в нашей стране, которая реализуется на федеральном уровне около 10 лет. Мы рассмотрим представления олимпийских волонтеров о счастье. В предыдущих работах было доказано, что участие в волонтерской деятельности связано с формированием чувства счастья и социального благополучия, но эксперты не уделяли достаточного внимания тому, что является счастьем. В данной статье представлены результаты комплексного исследования, которое включало количественный (онлайн-опрос) и качественный (интервью) этапы. Анализ полученных данных показал, что большая часть волонтеров считают себя счастливыми людьми. По мнению более половины опрошенных, окружающие их люди тоже счастливы. При выделении смыслов, которые вкладывались в понятие «счастье», наиболее популярными вариантами ответов были следующие: здоровье собственное и близких; семья, дети и близкие; материальное благополучие; профессиональная реализация. Важно, что участники исследования оценивают выше внутреннее состояние человека, испытывающего счастье, чем значение внешних обстоятельств.
Factors influencing breastfeeding duration among Portuguese mothers
Authors: de Oliveira Mariana Z.
Published: April 2022

Breastfeeding is extensively associated with significant benefits for maternal and child health. The World Health Organization recommends that infants be breastfed up to 24 months. The decision to breastfeed is affected by many factors. The present study aimed to assess the factors contributing to the duration of breastfeeding. An online questionnaire was applied to 351 Portuguese mothers of infants under five years old to collect data on socioeconomic, obstetric, and breastfeeding factors. Conditions that contribute to the duration of breastfeeding were information and education about the topic (p≤0.001), residence area (p≤0.001), number of children (p=0.002), duration of pregnancy (p=0.015), previous experience with breastfeeding (p≤0.001), and difficulties during breastfeeding (p=0.035). In conclusion, among the modifiable barriers which influence breastfeeding cessation, breastfeeding education and information is essential to improve breastfeeding rates. Keywords: Breastfeeding, duration of breastfeeding, literacy, infant nutrition, Portugal
Management of Posterior Capsule Rupture Complication in Cataract Patient with High Myopia and Partial Thickness Macular Hole
Authors: Nurhidayat Bimanda Rizki , Hermawan Dicky
Published: April 2022

Introduction: To report clinical outcome after posterior capsule rupture complication in a cataract patient with partial-thickness macular hole. Case presentation: A 49-year-old woman was presented with blurred vision of the left eye two years before admission. The blurred vision increased, accompanied by eye dazzled on light exposure. There was a history of myopia on both eyes and partial-thickness macular hole in the left eye. The left eye visual acuity was 3/60 with S-7.00 correction became 5/12 no improvement with pinhole. There was a partial-thickness macular hole on the left eye in the optical coherence tomography macula. Cataract surgery was performed with intraoperative posterior capsule rupture (PCR) complication. Follow-up had been monitored from day-1 until day-60 postoperatively. Conclusions: The decision of performing cataract surgery prior to macular hole surgery is a good decision. Any intraoperative complication such as posterior capsule rupture should be followed up closely to avoid macular hole worsening. Long-term follow-up should be done to prevent the late complication after surgery.
Final results of a 2:1 control-case observational study using interferon beta and interleukin-2, in addition to first-line hormone therapy, in estrogen receptor-positive, endocrine-responsive metastatic breast cancer patients
Authors: Nicolini Andrea , Rossi Giuseppe , Ferrari Paola , Morganti Riccardo , Carpi Angelo
Published: April 2022

Aim: We conducted a pilot study that combines immunotherapy (cyclic interleukin-2 interferon-beta sequence) and hormone therapy (HT) to overcome endocrine resistance in metastatic breast cancer. Methods: The final results of a 2:1 control-case retrospective observational study are here shown following 22 additional months of postoperative follow-up and 6 further controls. There were 95 controls and 42 cases in total. The 95 controls were ER+/HER2- metastatic breast cancer patients who underwent first-line HT with aromatase inhibitors (AIs) or fulvestrant. Twenty-eight of them (28.9%) also received biological drugs including cyclin kinase inhibitors (CKIs). The 42 cases were ER+ metastatic breast cancer patients who received interferon beta-interleukin-2 immunotherapy in addition to first-line HT. Selective estrogen receptor modulators/down-regulators (SERMs/SERDs) were used for HT in 39 (92.9%) of them and AIs in the remaining 3. Results: Median progression-free survival (PFS) and overall survival (OS) were significantly longer in the 42 studied patients who received hormone immunotherapy (HIT) than in the 95 controls (median time 33 vs. 18 months, P = 0.002, and 81 vs. 62 months, P = 0.019). In the analysis adjusted for disease-free interval (DFI), hormone receptor, HER2 status, visceral involvement, AIs, and biological therapy, the PFS and OS hazard ratio (HR) further increased in favor of the 42 cases (P = 0.004 and P = 0.044 respectively). In the same ER+/HER2- metastatic breast cancer patients treated with both AIs and CKIs, a median PFS ranging from 25.3 to 28.18 months and a median OS of 37.5 months were observed. Conclusions: This study strongly suggests multi-center randomized clinical trials should be performed to enter our proposed immunotherapy into clinical practice.
Surgical route and pathological risk factors in early cervical cancer - Node Zero (SURPEC-N0)
Authors: Shylasree T S , Gupta Stuti , Patil Akshay , Singh Pooja , Maheshwari Amita , Menon Santosh , Chopra Supriya , Gurram Lavanya , Popat Palak , Mahantshetty Umesh , Kerkar Rajendra
Published: April 2022

Aim: The aim of this study is to compare disease-free survival (DFS) and overall survival (OS) in patients with stage I cervical cancer (≤ 4cms, lymph node-negative) undergoing open radical hysterectomy (ORH) vs. minimally invasive radical hysterectomy (MIRH). Methods: All patients undergoing radical hysterectomy between January 2012-December 2018 from the largest tertiary referral cancer centre were included. A 1:1 propensity matching was done based on four independent prognostic factors to compare DFS and OS with the route of surgery. Results: One hundred and ninety-nine patients were included during the study period. The median age of the cohort was 50 years. The median follow-up of patients was 47 months. Following 1:1 propensity matching, a total of 174 patients were analysed for DFS and OS in ORH (n = 87) and MIRH (n = 87) groups. Protective measure was used in two-thirds of the patients during MIRH. Twenty-nine patients (16.7%) had recurrences. For the matched cohort (n = 174), the DFS at 36 and 60 months was 84.8% (78.1%-89.6%) and 81% (73.4%-86.6%) respectively and the OS was 96.5% (91.7%-98.5%) and 95.6% (90.3%-98%) respectively. There was no statistically significant difference in DFS or OS between ORH and MIRH. Conclusion: The present study showed no difference in oncological outcomes in MIRH compared to ORH. Retrospective audits on patient characteristics such as screening/vaccination history along with surgical technique/load and matching for crucial risk factors should be factored in future studies to eliminate the possible methodological errors.
Hepatocellular carcinoma on the background of nonalcoholic fatty liver disease: epidemiological update
Authors: Desjonqueres Elvire , Gigante Elia
Published: April 2022

The epidemiological features of hepatocellular carcinoma have changed significantly in the last decades. While for a long-time viral hepatitis and alcohol consumption have been the leading risk factors, the current spread of obesity and type 2 diabetes has contributed to the emergence of non-alcoholic fatty liver disease (NAFLD) worldwide, which has become the leading chronic liver disease as well as one of the main etiologies of hepatocellular carcinoma (HCC), especially in western countries. In this review, we resume the latest data about the epidemiology of metabolic liver disease and HCC arising from NAFLD and discuss the main clinical and molecular features leading to the progression of liver disease and the development of HCC in NAFLD. The emerging concept of metabolic associated fatty liver disease and its association with the development of HCC are also introduced.
FITOKIMIA 5 JENIS POHON DI KHDTK UNIVERSITAS LAMBUNG MANGKURAT MANDIANGIN KALIMANTAN SELATAN
Authors: Wibisono Agung , Sunardi Sunardi , Radam Rosidah R
Published: April 2022

Aims of the study is to identify phytochemical components (alkaloid, flavonoid, saponin, quinone, triterpenoid, and tannin) of 5 species growth in University of Lambung Mangkurat (ULM) Kawasan Hutan Dengan Tujuan Khusus (KHDTK = Education and Training Forest) area. These species are Madang Pirawas, Margatahan, Alaban Timbasu, Rawa Rawa Pipit, and Pulantan. Chemical analysis conducted in Wood Chemistry Laboratory, Faculty of Forestry ULM. The result shows that alkaloid component is found in Madang Pirawas, Margatahan, Alaban Timbasu, Rawa Rawa Pipit, and Pulantan’s leaves. Alaban Timbasu has more alkaloid than the others. Flavonoid component is found in Madang Pirawas, Margatahan, Rawa Rawa Pipit, and Pulantan’s leaves.Rawa Rawa Pipit has more flavonoid than the others. Saponin component is found in Madang Pirawas, Margatahan, Alaban Timbasu, Rawa Rawa Pipit, and Pulantan’s leaves. Pulantan has more saponin than the others. Quinone component is found in Madang Pirawas, Margatahan, Alaban Timbasu, Rawa Rawa Pipit, and Pulantan’s leaves. Madang Pirawas has more quinone than the others. Steroid component is found in Margatahan, Alaban Timbasu, and Rawa Rawa Pipit’s leaves. Alaban Timbasu has more steroid than the others.Triterpenoids component is found in Margatahan, Alaban Timbasu, and Rawa Rawa Pipit’s leaves. Alaban Timbasu has more triterpenoid than the others.Tannin component is found in Madang Pirawas, Margatahan, Rawa Rawa Pipit and Pulantan’s leaves. Rawa Rawa Pipit has more tannin than the others.
STUDI PERTUMBUHAN NYAWAI (Ficus variegata Blume) DI KHDTK RIAM KIWA KALIMANTAN SELATAN
Authors: Wicaksono Farhan Aryo , Pujawati Eny Dwi , Payung Damaris
Published: April 2022

The increase of timber consumption by the industry is not balanced with the supply of raw materials which is precisely reduced in number. One of the types of alternative plants that can be utilized is Nyawai. This research aims to determine the variation of growth and percent of life of each family, in order to provide recommendations of the best families that are able to adapt in a KHDTK Riam Kiwa environment. This research uses Nyawai plant in forest area with special purpose (KHDTK) Riam Kiwa is 27 months old with 9 families from 3 different Provenans namely South Kalimantan, East Kalimantan and central Kalimantan with a planting distance of 3 m x 3 m. Based on measurements obtained by the result of the highest lifetime survival percentage of 27 months Nyawai which averages 96%, the average height is 5, 539 m, the average diameter of 9.9 cm and the average bar straightness 4.45.
LIFE FORCE AND GROWTH QUALITY OF WHITE JABON (Anthocephaluscadamba) ON VARIOUS OF SOIL TYPES IN POST-MINING CEMENT AREAS
Authors: Harmoko Harmoko , Arifin Yudi Firmanul , Peran Setia Budi
Published: April 2022

Lahan kegiatan semen pasca penambangan harus direhabilitasi dan direvegetasi sesuai dengan peraturan yang berlaku di Indonesia. Jabon putih (Anthocephaluscadamba) adalah salah satu spesies alternatif yang ditanam di lahan semen pascatambang, karena spesies ini mampu hidup di tanah terbuka dan tidak subur. Penelitian ini dilakukan untuk mengetahui kemampuan hidup dan pertumbuhan jabon putih di lahan bekas tambang semen yang memiliki berbagai jenis tanah, yaitu laterit, tanah liat dan batu kapur. Metode yang digunakan adalah melakukan inventarisasi dan pengukuran tanaman Jabon putih yang ditanam di berbagai jenis tanah (laterit, tanah liat dan batu kapur). Penelitian dilakukan selama tiga bulan dengan durasi pengukuran setiap bulan untuk 300 tanaman dengan masing-masing jenis tanah terdiri dari 100 tanaman. Hasil penelitian menunjukkan persentase kelangsungan hidup tanaman jabon putih di laterit, tanah liat, dan batu kapur masing-masing adalah 91%, 87% dan 93%. Kualitas tanaman sehat di tanah laterit adalah 50%, tanaman tidak sehat 37%, tanaman mendekam 4% dan tanaman mati 9%, di tanah liat jumlah tanaman sehat 46%, tanaman tidak sehat 32%, mendekam tanaman 9% dan tanaman mati 13%, sedangkan di tanah kapur jumlah tanaman sehat adalah 67%, tanaman tidak sehat 24%, tanaman merana 2% dan tanaman mati 7%. Tingkat pertumbuhan rata-rata pada tanaman Jabon putih terjadi di laterit, tanah liat dan batugamping masing-masing 1,51 cm, 1,61 cm, dan 1,81. Pertumbuhan jumlah daun jabon di tanah laterit, tanah liat, dan kapur masing-masing adalah 0,59, 0,61 dan 0,67. Pertumbuhan tanaman jabon putih terbaik dari ketiga jenis tanah tersebut adalah tanah kapur.