bluuebunny/crossref_metadata_2025 huggingface dataset:
InsectOR—Webserver for sensitive identification of insect olfactory receptor genes from non-model genomes
Authors: Karpe Snehal Dilip , Tiwari Vikas , Ramanathan Sowdhamini
Published: January 2021

Insect Olfactory Receptors (ORs) are diverse family of membrane protein receptors responsible for most of the insect olfactory perception and communication, and hence they are of utmost importance for developing repellents or pesticides. Accurate gene prediction of insect ORs from newly sequenced genomes is an important but challenging task. We have developed a dedicated webserver, ‘insectOR’, to predict and validate insect OR genes using multiple gene prediction algorithms, accompanied by relevant validations. It is possible to employ this server nearly automatically and perform rapid prediction of the OR gene loci from thousands of OR-protein-to-genome alignments, resolve gene boundaries for tandem OR genes and refine them further to provide more complete OR gene models. InsectOR outperformed the popular genome annotation pipelines (MAKER and NCBI eukaryotic genome annotation) in terms of overall sensitivity at base, exon and locus level, when tested on two distantly related insect genomes. It displayed more than 95% nucleotide level precision in both tests. Finally, given the same input data and parameters, InsectOR missed less than 2% gene loci, in contrast to 55% loci missed by MAKER forDrosophila melanogaster. The webserver is freely available on the web athttp://caps.ncbs.res.in/insectOR/and the basic package can be downloaded fromhttps://github.com/sdk15/insectORfor local use. This tool will allow biologists to perform quick preliminary identification of insect olfactory receptor genes from newly sequenced genomes and also assist in their further detailed annotation. Its usage can also be extended to other divergent gene families.
A simple, clinically applicable motor learning protocol to increase push-off during gait: A proof-of-concept
Authors: Bertrand-Charette Michaël , Nielsen Jens Bo , Bouyer Laurent J.
Published: January 2021

Objective

Task-specific training is often used in functional rehabilitation for its potential to improve performance at locomotor tasks in neurological populations. As push-off impairment are often seen with these patients, this functional approach shows potential to retrain gait overground to normalize the gait pattern and retrain the ability to improve gait speed. The main objective of this project was to validate, in healthy participants, a simple, low-cost push-off retraining protocol based on task-specific training that could be implemented during overground walking in the clinic.

Methods

30 healthy participants walked in an 80-meter long corridor before, during, and after the application of an elastic resistance to the right ankle. Elastic tubing attached to the front of a modified ankle-foot orthosis delivered the resistance during push-off. Relative ankle joint angular displacements were recorded bilaterally and continuously during each walking condition.

Results

On the resisted side, participants presented aftereffects (increased peak plantarflexion angle from 13.4±4.2° to 20.0±6.4°, p<0.0001 and increased peak plantarflexion angular velocity from 145.8±22.7°/s to 174.4±37.4°/s, p<0.0001). On the non-resisted side, aftereffects were much smaller than on the resisted side suggesting that the motor learning process was mainly specific to the trained leg.

Conclusion

This study shows the feasibility of modifying push-off kinematics using an elastic resistance applied at the ankle while walking overground. This approach represents an interesting venue for future gait rehabilitation.
The role of posttranslational modifications in generating neo-epitopes that bind to rheumatoid arthritis-associated HLA-DR alleles and promote autoimmune T cell responses
Authors: Becart Stephane , Whittington Karen B. , Prislovsky Amanda , Rao Navin L. , Rosloniec Edward F.
Published: January 2021

While antibodies to citrullinated proteins have become a diagnostic hallmark in rheumatoid arthritis (RA), we still do not understand how the autoimmune T cell response is influenced by these citrullinated proteins. To investigate the role of citrullinated antigens in HLA-DR1- and DR4-restricted T cell responses, we utilized mouse models that express these MHC-II alleles to determine the relationship between citrullinated peptide affinity for these DR molecules and the ability of these peptides to induce a T cell response. Using a set of peptides from proteins thought to be targeted by the autoimmune T cell responses in RA, aggrecan, vimentin, fibrinogen, and type II collagen, we found that while citrullination can enhance the binding affinity for these DR alleles, it does not always do so, even when in the critical P4 position. Moreover, if peptide citrullination does enhance HLA-DR binding affinity, it does not necessarily predict the generation of a T cell response. Conversely, citrullinated peptides can stimulate T cells without changing the peptide binding affinity for HLA-DR1 or DR4. Furthermore, citrullination of an autoantigen, type II collagen, which enhances binding affinity to HLA-DR1 did not enhance the severity of autoimmune arthritis in HLA-DR1 transgenic mice. Additional analysis of clonal T cell populations stimulated by these peptides indicated cross recognition of citrullinated and wild type peptides can occur in some instances, while in others cases the citrullination generates a novel T cell epitope. Finally, cytokine profiles of the wild type and citrullinated peptide stimulated T cells unveiled a significant disconnect between proliferation and cytokine production. Altogether, these data demonstrate the lack of support for a simplified model with universal correlation between affinity for HLA-DR alleles, immunogenicity and arthritogenicity of citrullinated peptides. Additionally they highlight the complexity of both T cell receptor recognition of citrulline as well as its potential conformational effects on the peptide:HLA-DR complex as recognized by a self-reactive cell receptor.
Simultaneous ventilation in the Covid-19 pandemic. A bench study
Authors: Guérin Claude , Cour Martin , Stevic Neven , Degivry Florian , L’Her Erwan , Louis Bruno , Argaud Laurent
Published: January 2021

COVID-19 pandemic sets the healthcare system to a shortage of ventilators. We aimed at assessing tidal volume (VT) delivery and air recirculation during expiration when one ventilator is divided into 2 test-lungs. The study was performed in a research laboratory in a medical ICU of a University hospital. An ICU (V500) and a lower-level ventilator (Elisée 350) were attached to two test-lungs (QuickLung) through a dedicated flow-splitter. A 50 mL/cmH2O Compliance (C) and 5 cmH2O/L/s Resistance (R) were set in both A and B test-lungs (A C50R5 / B C50R5, step1), A C50-R20 / B C20-R20 (step 2), A C20-R20 / B C10-R20 (step 3), and A C50-R20 / B C20-R5 (step 4). Each ventilator was set in volume and pressure control mode to deliver 800mL VT. We assessed VT from a pneumotachograph placed immediately before each lung, pendelluft air, and expiratory resistance (circuit and valve). Values are median (1st-3rd quartiles) and compared between ventilators by non-parametric tests. Between Elisée 350 and V500 in volume control VT in A/B test- lungs were 381/387 vs. 412/433 mL in step 1, 501/270 vs. 492/370 mL in step 2, 509/237 vs. 496/332 mL in step 3, and 496/281 vs. 480/329 mL in step 4. In pressure control the corresponding values were 373/336 vs. 430/414 mL, 416/185 vs. 322/234 mL, 193/108 vs. 176/ 92 mL and 422/201 vs. 481/329mL, respectively (P<0.001 between ventilators at each step for each volume). Pendelluft air volume ranged between 0.7 to 37.8 ml and negatively correlated with expiratory resistance in steps 2 and 3. The lower-level ventilator performed closely to the ICU ventilator. In the clinical setting, these findings suggest that, due to dependence of VT to C, pressure control should be preferred to maintain adequate VT at least in one patient when C and/or R changes abruptly and monitoring of VT should be done carefully. Increasing expiratory resistance should reduce pendelluft volume.
A novel cancer immunotherapy using tumor-infiltrating B cells in the APCmin/+ mouse model
Authors: Wang Xinying , Asami Shohei , Kitamura Daisuke
Published: January 2021

Accumulating evidence has suggested a correlation of tumor infiltrating B cells (TiBcs) and a good prognosis of cancer diseases. In some cases, TiBcs appear to have experienced antigen stimulation since they have undergone class-switching and somatic hypermutation and formed tertiary lymphoid structures around tumors together with T cells. Assuming TiBcs include those that recognize some tumor antigens, we sought to investigate their possible usefulness for cell-mediated immunotherapies. To expand usually small number of TiBcs in vitro, we modified our B cell culture system: we transduced B cells with ERT2-Bach2 so that they grow unlimitedly provided with tamoxifen, IL-21 and our original feeder cells. Such cells differentiate into plasma cells and produce antibodies upon withdrawal of tamoxifen, and further by addition of a Bach2-inhibitor in vitro. As a preliminary experiment, thus expanded splenic B cells expressing a transgenic antigen receptor/antibody against hen egg lysozyme were intravenously injected into mice pre-implanted with B16 melanoma cells expressing membrane-bound HEL in the skin, which resulted in suppression of the growth of B16 tumors and prolonged survival of the recipient mice. To test the usefulness of TiBcs for the immunotherapy, we next used APCmin/+ mice as a model that spontaneously develop intestinal tumors. We cultured TiBcs separated from the tumors of APCmin/+ mice as above and confirmed that the antibodies they produce recognize the APCmin/+ tumor. Repeated injection of such TiBcs into adult APCmin/+ mice resulted in suppression of intestinal tumor growth and elongation of the survival of the recipient mice. Serum antibody from the TiBc-recipient mice selectively bound to an antigen expressed in the tumor of APCmin/+ mice. These data suggest a possibility of the novel individualized cancer immunotherapy, in which TiBcs from surgically excised tumor tissues are expanded and infused into the donor patients.
Association of serum adiponectin and myostatin levels with skeletal muscle in patients with obesity: A cross-sectional study
Authors: Kurose Satoshi , Onishi Katsuko , Takao Nana , Miyauchi Takumi , Takahashi Kazuhisa , Kimura Yutaka
Published: January 2021

Background

Adiponectin has been reported to be associated with lower skeletal muscle mass and skeletal strength and may be involved in skeletal muscle regulation along with myostatin. This study aims to evaluate the association between serum adiponectin and myostatin levels and identify independent factors using body composition and metabolic parameters in patients with obesity.

Methods

Overall, 148 patients (age, 45.9 ± 14.3 years, body mass index, 37.2 ± 8.0 kg/m2) who initially visited the outpatient clinic of obesity between November 2013 and November 2019 were included. Body composition was measured using InBody 720 and dual energy X-ray absorptiometry. In addition, muscle strength, vascular function, and metabolic parameters were measured. Serum levels of adiponectin, leptin, myostatin, and irisin were measured from blood samples.

Results

The serum adiponectin level was 2.9 μg/mL (1.7–4.1 μg/mL), and the serum myostatin level was 2398.4 pg/mL (1,777.1–2952.5 pg/mL). The stepwise regression analysis revealed less leg strength, homeostasis model assessment of insulin resistance, and C-reactive protein as an independent predictor of serum adiponectin levels based on the significance of the univariate analysis (R2= 0.190, P < 0.001). A high appendicular lean mass/body weight, reactive hyperemia index, and irisin were independent factors for serum myostatin levels (R2= 0.260, P < 0.001)

Conclusion

The serum adiponectin level was associated with less muscle strength. Although serum myostatin was associated with a high appendicular lean mass, it is possible that myostatin was regulated by the percentage of body weight from appendicular lean mass.
Enhanced biofilm and extracellular matrix production by chronic carriage versus acute isolates of Salmonella Typhi
Authors: Devaraj Aishwarya , González Juan F. , Eichar Bradley , Thilliez Gatan , Kingsley Robert A. , Baker Stephen , Allard Marc W. , Bakaletz Lauren O. , Gunn John S. , Goodman Steven D.
Published: January 2021

SalmonellaTyphi is the primary causative agent of typhoid fever; an acute systemic infection that leads to chronic carriage in 3–5% of individuals. Chronic carriers are asymptomatic, difficult to treat and serve as reservoirs for typhoid outbreaks. Understanding the factors that contribute to chronic carriage is key to development of novel therapies to effectively resolve typhoid fever. Herein, although we observed no distinct clustering of chronic carriage isolates via phylogenetic analysis, we demonstrated that chronic isolates were phenotypically distinct from acute infection isolates. Chronic carriage isolates formed significantly thicker biofilms with greater biomass that correlated with significantly higher relative levels of extracellular DNA (eDNA) and DNABII proteins than biofilms formed by acute infection isolates. Importantly, extracellular DNABII proteins include integration host factor (IHF) and histone-like protein (HU) that are critical to the structural integrity of bacterial biofilms. In this study, we demonstrated that the biofilm formed by a chronic carriage isolatein vitro, was susceptible to disruption by a specific antibody against DNABII proteins, a successful first step in the development of a therapeutic to resolve chronic carriage.
Relationship between CD4 T cell turnover, cellular differentiation and HIV persistence during ART
Authors: Bacchus-Souffan Charline , Fitch Mark , Symons Jori , Abdel-Mohsen Mohamed , Reeves Daniel B. , Hoh Rebecca , Stone Mars , Hiatt Joseph , Kim Peggy , Chopra Abha , Ahn Haelee , York Vanessa A. , Cameron Daniel L. , Hecht Frederick M. , Martin Jeffrey N. , Yukl Steven A. , Mallal Simon , Cameron Paul U. , Deeks Steven G. , Schiffer Joshua T. , Lewin Sharon R. , Hellerstein Marc K. , McCune Joseph M. , Hunt Peter W.
Published: January 2021

The precise role of CD4 T cell turnover in maintaining HIV persistence during antiretroviral therapy (ART) has not yet been well characterized. In resting CD4 T cell subpopulations from 24 HIV-infected ART-suppressed and 6 HIV-uninfected individuals, we directly measured cellular turnover by heavy water labeling, HIV reservoir size by integrated HIV-DNA (intDNA) and cell-associated HIV-RNA (caRNA), and HIV reservoir clonality by proviral integration site sequencing. Compared to HIV-negatives, ART-suppressed individuals had similar fractional replacement rates in all subpopulations, but lower absolute proliferation rates of all subpopulations other than effector memory (TEM) cells, and lower plasma IL-7 levels (p = 0.0004). Median CD4 T cell half-lives decreased with cell differentiation from naïve to TEM cells (3 years to 3 months, p<0.001). TEM had the fastest replacement rates, were most highly enriched for intDNA and caRNA, and contained the most clonal proviral expansion. Clonal proviruses detected in less mature subpopulations were more expanded in TEM, suggesting that they were maintained through cell differentiation. Earlier ART initiation was associated with lower levels of intDNA, caRNA and fractional replacement rates. In conclusion, circulating integrated HIV proviruses appear to be maintained both by slow turnover of immature CD4 subpopulations, and by clonal expansion as well as cell differentiation into effector cells with faster replacement rates.
PRIME biases of the digital age: A conceptual model for navigation and survival
Authors: Dowd John
Published: January 2021

Digital technologies continue to shape nearly every facet of our lives in ways both seen and unseen. Given their systemic (i.e. environmental) nature and the rate at which their impacts emerge, anti-environments are needed to provide the kind of conscious awareness that Marshall McLuhan and subsequent others have called for. Towards this end, I introduce the PRIME model, which represents five key biases that emerge and/or are heightened within the digital environment. Ultimately, I argue that awareness of these biases and their effects can aid us in cultivating more constructive data habits at the social, cultural and political levels that serve, rather than subvert, humane and equitable ends.
Identity Discourses About Spain and Catalonia in News Media: Understanding Modern Secessionism, Clara Juárez Miró (2020)
Authors: Martínez-Expósito Alfredo
Published: January 2021

Review of: Identity Discourses About Spain and Catalonia in News Media: Understanding Modern Secessionism, Clara Juárez Miró (2020)

Lanham, MD: Lexington Books, xii+182 pp.,

ISBN 978-1-79360-964-9, h/bk, $90.00, £69.00
Alfonso X, Pero da Ponte e il «trobar natural». Sull’interpretazione di «Pero da Ponte, paro-vos sinal» (B487/V70)
Authors: Barberini Fabio
Published: January 2021

La prima parte di questo contributo ridiscute le ipotesi interpretative formulate fin ora sulla cantiga di Alfonso X, Pero da Ponte, paro-vos sinal (B487/V70) con particolare attenzione alle proposte di Vicenç Beltran (2005) e di Carlos Callón (2011), entrambe poco soddisfacenti: la prima per questioni cronologiche; la seconda perché fondata su interpretazioni poco convincenti e mal argomentate del testo di Alfonso X e di altre cantigas di Pero da Ponte. La seconda parte riesamina i legami di Alfonso X con la lirica provenzale: si studia il significato del sintagma trobar natural ―che rinvia a una precisa contrapposizione ideologica attiva nelle prime generazioni trobadoriche (in particolare Marcabru e Bernart de Ventadorn)―, e si indicano come possibili moventi della satira di Alfonso X due cantigas di Pero da Ponte, Se eu podesse desamar e Poys de mha morte gran sabor avedes, nelle quali il trovatore galego assume posizioni, al tempo stesso, irreligiose e anticortesi.
La «tuera» como fruto amargo de sufrimiento amoroso: entre el Cancionero General (1511) y El rayo que no cesa de Miguel Hernández (1936)
Authors: Beltrán Rafael
Published: January 2021

El Cancionero General de Hernando del Castillo (Valencia, 1511) presenta una canción de Pedro Fajardo, Adelantado de Murcia, con un encabezado que remite a unas «tueras» (una especie de pequeña calabaza silvestre), como invención o empresa. El sabor de la «tuera» es muy amargo y por ello, en las escasas ocasiones en que aparece el término en literatura, las «tueras» se asocian con la amargura del sufrimiento amoroso (y a veces tal vez con la gravedad y los pesares del embarazo y la crianza). Encontraremos una nueva utilización poética de la «tuera» solamente cuatro siglos después, en uno de los sonetos de Miguel Hernández, «Fuera menos penado», incluido en su libro El rayo que no cesa (1936). Tratamos de analizar y contestar algunos interrogantes en torno al mantenimiento, rescate o resurrección del término «tuera» y sus significados en los mismos contextos poéticos, si bien en horizontes de expectativas muy alejados en el tiempo.
Los romances de Judit: un curioso caso de autoedición
Authors: Laskaris Paola
Published: January 2021

En el presente trabajo se propone un estudio de un pliego suelto conservado en la Biblioteca Nacional de España que contiene siete romances, los primeros seis relacionados con la historia bíblica de Judit y Holofernes. El pliego, compuesto y recopilado por el impresor Juan Bautista (el único dato tipográfico explicitado en la portada) atrajo la atención de eruditos y estudiosos por su aspecto y su contenido. Tras aclarar definitivamente la procedencia y autoría del pliego, se analizan algunos pasajes en relación con la circulación (textual e iconográfica) del motivo bíblico en el Siglo de Oro.
Ambrosio Montesino e Íñigo de Mendoza: la sátira contra las mujeres y la autoría de las Coplas a la Verónica en HH1
Authors: Severin Dorothy S.
Published: January 2021

La autoría de las Coplas a la Veronica quedó oscurecida a causa del normalmente fiable Cancionero de Oñate Castañeda. El poema, que suele ser atribuido a Fray Íñigo de Mendoza, también se relaciona con Fray Ambrosio Montesino, no solo con una rúbrica, sino también con una nueva copla que bien pudiera ser apócrifa. Los ataques satíricos de ambos, Fray Íñigo y Fray Ambrosio, indican que el primer auditorio fue la corte noble, y especialmente la corte de los reyes. Originalmente, la promulgación de esta poesía en los cancioneros manuscritos es una manera de legitimar la nueva reina y su reinado después de la larga guerra civil.
Ressenya de La poesia oggetiva nella letteratura catalana medievale. Antologia di testi con traduzione a fronte
Authors: Martos Josep Lluís
Published: January 2021

Anna Maria Compagna, Michela Letizia i Núria Puigdevall Bafaluy, La poesia oggetiva nella letteratura catalana medievale. Antologia di testi con traduzione a fronte, Canterano, Aracne Editrice, 2019 («Dialogoi Medievalia», 3), 339 pp. ISBN 978-88-255-2337-9.
Variasi Fluks CO2 Udara-Laut di Perairan Pesisir Pulau Bintan
Authors: Afdal Afdal , Prayitno Hanif Budi , Wahyudi A'an Johan , Lastrini Suci
Published: January 2021

Variation of Air-Sea CO2 Fluxes in Bintan Island Coastal Water. Eastern part of Bintan coastal water plays a major role as CO2 sink. However, flux and partial pressure of CO2 (pCO2) dynamically follows spatio-temporal variability. Spatio-temporal variability of CO2 flux may shows the whole condition of Bintan Island coastal water, especially in correlation with the primary production. Systematic study on variability of CO2 flux from or to the watern column is essential to understand the whole conditions of Bintan Island coastal water. This study aims to understand the spatio-temporal variation of CO2 fluxes in Bintan Island coastal water, and the factors influencing it. This study was conducted in the eastern part of Bintan coastal water in April and August 2014. In addition, this study was also conducted in the southern and northern parts in April 2016. CO2 fluxes dynamics were calculated from pCO2 (surface water and atmosphere), temperature, salinity, and wind speed. The result showed that almost all parts of the Bintan coastal water were carbon sources during first transition season. The largest CO2 emission was observed in the northern part (4.02 ± 1.92 mmol/m2/d) followed by the southern part (2.28 ± 0.80 mmol/m2/d) and then the eastern part (0.46 ± 0.28 mmol/m2/d). The eastern part temporally turned into CO2 sink in the southwest monsoon season (-0.27 ± 0.10 mmol/m2/d). Temperature was the main factor causing spatial and temporal variability of air-sea CO2 fluxes in the Bintan coastal water. Spatially, the presence of seagrass and coral reef ecosystems causes the partial pressure of surface water CO2 in the eastern part of waters of Bintan is much lower compared to the waters of north and south Bintan, thus emitting less CO2 to the atmosphere
“Enquanto você lia este texto, mais um brasileiro morreu por causa do coronavírus”. Pandemia, necromídia e estética da morte na Folha de S. Paulo .
Authors: De França De França Torres , Muneiro Lilian Carla
Published: January 2021

O presente artigo tem por objetivo ampliar o conceito de Necropolítica, desenvolvido pelo pensador camaronês Achille Mbembe (2018), para outras áreas da vida social, mais precisamente a mídia. Trabalhamos com duas hipóteses. 1. A sociedade midiatizada é cada vez mais voltada para a exibição da violência e da morte como espetáculo, processo acentuado nos últimos cinco meses devido à pandemia do coronavírus. 2. Os jornais tentam empreender um movimento de retorno ao protagonismo na formulação das narrativas que circulam socialmente enquanto apelam para uma estética da violência. Nosso material empírico são duas edições do jornal Folha de S. Paulo, nas quais a empresa demonstra com transparência sua estratégia de estetização da morte.
SOCIO-ECONOMIC PRECONDITIONS FOR THE FORMATION OF PRE-RETIREMENT HUMAN CAPITAL
Authors: Malikova V.V.
Published: January 2021

The article focuses on pre-retirement age employee’s assessment as a development resource of regional economy. Recently, assessments of the leading role of human capital in modern socio-economic development have become widespread in the scientific literature. The key parameter that determines the development of the region is the level of formed and accumulated human capital of pre-retirees, which should be evaluated, developed and effectively used, and when evaluating it, it is necessary to take into account the specific conditions for the formation of individuals within the framework of the considered models of economic human. The article analyzes the main features of human models from the standpoint of economic theory, offers a model of a modern prepensioner, and justifies the need to consider the impact of economic systems of management corresponding to the periods of labor activity when assessing the human capital of pre-retirees. During there search the following methods were used: the analysis of special and thematic literature, legal and regulatory sources, system processing, data analysis and visualization.
DEVELOPMENT OF ADDIMAL PROFESSIONAL EDUCATION ACCORDANCE WITH MODERN LABOR MARKET REQUIREMENTS
Authors: Moroshkina M.V. , Murashkina L.V.
Published: January 2021

The presented article considers topical issues of functioning and development of the system of additional vocational education, as an element of continuing vocational education, in ensuring breakthrough socio-economic development of the country in modern conditions. As part of the analysis of statistical data, priority areas of development of the DPO system were considered and the main possible consumers of this service sector, as well as the age distribution of potential consumers, were investigated. The information base of the study is the statistical data of Rosstat and the information provided by the Internet sources on the functioning of the system of additional vocational education. Within the framework of the study, the main problems and key contradictions that inhibit the development of the DPO system in the conditions of constant modernization of the education system and significant changes in the demands of the labor market for a competitive labor force were analyzed and highlighted. The results obtained in the study can be used in the development of strategic and policy documents, as well as the formation of measures for the development of the education sector, in particular the system of additional vocational education.
A referenciapont-elmélet mint a hiányos információjú szerződések gondolatkörének új irányzata (The concept of ‘reference points’ as a new direction in the ‘incomplete contract’ theory)
Authors: Berde Éva
Published: January 2021

A cikk az alig több mint öt éve született referenciapont-elméletet mutatja be, ismerteti és értékeli a témában eddig megjelent cikkeket és a nagyobb horderejű munkaanyagokat. A referenciapont-elmélet arra a kérdésre keresi a választ, hogy mi a vállalat optimális mérete, és mikor érdemesebb a termelési kooperációt nem a vállalaton belül, a különböző egységek koordinációjával megoldani, hanem külső vállalatok segítségével, a piacon keresztül megvalósítani. A referenciapont-elmélet az azonos kérdések megválaszolására törekvő hiányos szerződések elméletét ért kritika hatására született meg, és saját, újonnan megfogalmazott feltételrendszerét számos ponton ötvözi a hiányos szerződések hipotéziseivel, ugyanakkor bizonyításai során felhasználja a standard közgazdasági irányzat több eszközét is. A cikk a friss eredmények bemutatása mellett megkísérli előre becsülni a referenciapont-elmélet várható jövőbeli fejlődési irányait is. ____ The concept of reference points was established slightly more than five years ago, and it deals with the same boundary of firm related questions as the incomplete contract theory. The present review shows the most important journals and research papers in this field. Reference point theory arose out of a criticism of some of the elements of incomplete contract theory. Reference point theory combines newly- formulated hypotheses with some of the assumptions of incomplete contracts. The theory also uses some of the proving tools of standard economics. The author’s study not only shows the main results of the reference point theory, but it also tries to predict some possible future developments within the theory.
Az IKT-eszközökkel kapcsolatos preferenciák és használatuk előrejelzése (Preferences and usage forecast of ICT tools)
Authors: Monda Eszter , Ugray Zsolt
Published: January 2021

A szerzők ebben a tanulmányukban az információs és kommunikációs technológiai (továbbiakban IKT) eszközök közül az asztali számítógépekkel (desktopok), laptopokkal (notebookok és netbookok), táblagépekkel és okostelefonokkal foglalkoznak. Az IKT-eszközök elterjedtségének vizsgálatánál meghatározó szerepet játszik a technológia jelenléte mellett a társadalom befogadóképessége. A technológia és társadalom kapcsolatát különböző módszerekkel és modellekkel mutatják be, melyek indokolják ezen eszközök növekvő használatának szükségességét. Ebben a tanulmányban a modellekből és a felmérésekből összeállított tényezők beépítésével és az általuk feldolgozott kérdőívek elemzése által kirajzolódnak minták és olyan összefüggések, amelyek magyarázatot adhatnak a különböző eszközhasználat okainak megértésére. _____ In their study the authors deal with the desktop computers (Desktop), laptops (notebooks and netbooks), smartphones and tablet machines among of information and communication technology (hereinafter referred to as ICT) tools. The capacity of society is one of the key elements in the examination of spread of ICT. The relationship between technology and society is presented with different methods and models that are justified by the need for increasing the use of these devices. In this paper such samples and correlations are emerged of the models and surveys, which may explain the reasons for understanding of the different tool use.
Eredményes projektszervezet kialakítása funkcionális, hierarchikus szervezetek esetén: egy példa az államigazgatásból (Development of effective project organization in functional, hierarchical organizations: an example from public administration)
Authors: Futó Iván
Published: January 2021

Az államigazgatásban – itthon és külföldön is – a projektek jelentős százaléka időben csúszik, nem azt eredményezi, amit eredetileg elvártak, a szakmai résztvevők szerint túladminisztrált, a munkatársak tevékenysége nem áttekinthető. Ezeknek a problémáknak a nagy része a projektszervezet és a hierarchikusfunkcionális- hivatali szervezet egymás mellett éléséből és a nehezen szinkronizálható együttműködésből fakad. A cikkben egy, a gyakorlatban bevált módszertant mutat be a szerző, amely adott feltételrendszer mellett nagymértékben kiküszöböli a fent említett hiányosságokat és a szervezet napi működésébe illeszkedő tevékenységek sorozatára vezeti vissza a projekttevékenységeket. A módszer egy gyakorlati problémából – a volt APEH-es és VP-s rendszerek integrálása a NAV-ba – indult ki, azonban a szerző véleménye szerint alkalmazható más, funkcionális alapokon felépülő szervezetnél is. _____ The high percentage of public sector projects slips in time, the result is not that what was expected initially, those are overadministrated by according to the professional participants’ opinion, and the activity of staff does not clear. In this article the author describes a best practice methodology, which led the project activities to series of activities which fit to the organization’s daily operations. The method started from a practical problem, but according to the author’s opinion it can be applied to other structured functional basis organizations.
A cash flow-kimutatás szabályozásainak nemzetközi összehasonlítása és csoportosítása (International comparison and classification of Cash Flow Statement regulations)
Authors: László Norbert
Published: January 2021

Az egyes nemzetek számviteli szabályozásának vizsgálatánál az adott ország sajátosságaiból eredően részben eltérő szabályozások alakultak ki. Az induktív megközelítésű vizsgálatok jellemzően a szabályozási kérdések széles körét fogják át, de csak néhány tényező mentén közelítve. A cash flow-kimutatások témakörénél a legtöbbször csak azt nézték, hogy van-e előírás a kimutatás elkészítésére, de a részletekkel már kevésbé foglalkoztak. Ebből adódóan e területen viszonylag kis különbséget mutattak ki ezek a felmérések. A szerző kutatása szerint a nemzeti cash flow-kimutatások szabályozásának részleteiben eltérések tapasztalhatók, és ezek alapján a nemzetek klaszterelemzéssel hierarchikusan csoportokba rendezhetők. _____ Research has found that as a result of their particularities, different countries have established partly different accounting frameworks. Studies with inductive approaches typically encompass a wide range of regulatory issues, but based on a limited number of factors only. In the case of Statements of Cash Flows, most studies have so far only examined the existence of rules governing the presentation of the statement, without an in-depth analysis of the details. Therefore, these studies only found relatively minor differences in this field. The author’s research shows that many differences exist in the details of national Cash Flow Statement regulations, which makes it possible to classify the countries in groups using the method of hierarchical clustering.
A projektfinanszírozás egyedi jellegzetességei (The individual characteristics of project finance)
Authors: Madácsi Roland
Published: January 2021

A szerző cikkében a projektfinanszírozás különleges ismertetőjegyeit kívánja bemutatni – úgymint a projektfinanszírozás fejlődését, a projektfinanszírozás és a vállalatfinanszírozás fontosabb különbségeit, valamint a sikeres projektfinanszírozás előfeltételeit. Ezen kívül foglalkozik még a projektfinanszírozás során alkalmazott pénzügyi mutatószámrendszer, e finanszírozási forma lehetséges hitel- és tőkeforrásai, továbbá a projektfinanszírozás során alkalmazott biztosítékok köre. Végezetül pedig a kivitelezési és üzemeltetési kockázatot elemzi, mint a projektfinanszírozás egyik legfontosabb kockázati tényezőjét. _____ In this article the author presents the special features of project finance, such as the development of project financing, important differences of project finance and corporate finance, as well as the preconditions for successful project financing. The author demonstrates the financial scorecards which are used in project finance, possible debt and equity sources of this financial form, and the securities which are used in the project finance. Finally, he analyzes the construction and operational risk, as one of the major risk factors for project finance.
Empagliflozin-Associated Pancreatitis: A Consideration for SGLT2 Inhibitors
Authors: Dziadkowiec Karolina N. , Stawinski Peter M. , Proenza Jose
Published: January 2021

Empagliflozin belongs to a class of sodium-glucose cotransporter-2 inhibitors, a medication approved by the US Food and Drug Administration in 2014 for the treatment of type 2 diabetes mellitus. Well-known side effects of this medication include symptomatic hypotension, hypoglycemia, and urinary tract infections among others. We present a case of severe epigastric abdominal pain consistent with acute pancreatitis in the setting of empagliflozin use, suggesting a possible drug-induced acute pancreatitis.
"O coração precisa ser pego de surpresa para ser incriminado"
Authors: Mota Lopes Mariana
Published: January 2021

O que separa os conceitos de erotismo e pornografia é algo tão indefinível e tão tênue quanto o que delimita o que é arte. Para o senso comum, a ideia de que o texto erótico tem maior preocupação com a forma e a linguagem utilizada é mais difundida; pensa-se que, ao contrário dos textos pornográficos, a preocupação e o objetivo maior do texto não seriam apenas a excitação do leitor, mas também a criação artística e a expressão literária.

Mas existem textos que, mesmo possuindo muitas das características comumente atribuídas a textos pornográficos, são tidos como eróticos. O contrário também pode ser observado. É nesse ponto que começa nossa análise. O que, então, determina quais textos recebem qual rótulo, ou melhor: quem determina. 

A partir da análise do conto de Natalia Borges Polesso, O coração precisa ser pego de surpresa para ser incriminado, e das teses acerca do que seria erotismo e pornografia e o que os diferencia, buscamos chegar à conclusão de que, na verdade, o que diferencia os dois tipos de texto não são suas características, mas sim o leitor que, a partir de seus ideais e experiências determinará, para si, se o que lê é erótico ou pornográfico.
Resenha do livro "Revisões do Cânone: estudos literários e teorias contra-hegemônicas"
Authors: Marinho Camargo Gabriel
Published: January 2021

A presente resenha pretende analisar de forma geral a totalidade dos textos que compõem a obra, com o objetivo de compreender a importância desses estudos para o mundo acadêmico assim como para a sociedade.
Quando as Mulheres Amam
Authors: Machado Silveira Gabriela , De Abreu Barbosa Adriana Maria
Published: January 2021

Esse trabalho objetiva analisar criticamente a produção discursiva de duas escritoras nordestinas, a saber: Rachel de Queiroz e Heleusa Câmara. Especificamente, busca-se averiguar como três personagens femininas em obras dessas autoras lidam com o amor romântico, se alguma delas o rejeita, critica, ou o tem como objetivo de vida.

PALAVRAS-CHAVE: Amor romântico. Gênero. Literatura de Autoria Feminina.
Definindo meninas e meninos
Authors: Castelliano de Vasconcelos Dalila , Cavalcante Borges Lucivanda , Maria Ribeiro Salomão Nádia
Published: January 2021

A pesquisa analisa as concepções de pais, mães e educadoras de crianças de 24 e 36 meses de idade da cidade de João Pessoa-PB, sobre o que é ser menina e ser menino, identificando o lugar que a afetividade ocupa nessas definições. Utilizou-se a análise de conteúdo.

PALAVRAS-CHAVE: Afeto. Gênero. Primeira Infância.
Francisco Alves da Silva Castilho: um professor na invenção da Escola Brasileira oitocentista
Authors: Borges Angélica , Teixeira Giselle Baptista
Published: January 2021

Neste artigo analisamos aspectos da trajetória de um professor público primário da Corte, Francisco Alves da Silva Castilho, que lecionou por aproximadamente 38 anos (1849-1887), com intuito de propiciar uma reflexão acerca dos diferentes papéis desempenhados pela docência na invenção da “Escola brasileira” Oitocentista e do próprio magistério. Castilho tornou-se autor de livros, escreveu em periódicos, participou de Conferências Pedagógicas e de associações que indicam diferentes modos de inserção na sociedade. O estudo usa as contribuições de Antonio Nóvoa, Escolano Benito e Edward Thompson no que se refere ao processo de profissionalização docente; à configuração da história escolar e do magistério; e ao conceito de experiência, para se pensar a constituição da trajetória docente. A investigação utilizou documentos manuscritos do Arquivo Geral da Cidade do Rio de Janeiro, relatórios da Inspetoria Geral de Instrução, manuais escolares e periódicos localizados na Biblioteca Nacional.
Humboldt anticolonial
Authors: Barbosa Tulio
Published: January 2021

O presente trabalho é resultado da participação em evento organizado pelo PET MEC Geografia da Universidade Federal de Uberlândia e convidado para transcrever a fala que ocorreu no seminário “Clássicos da Geografia”, tal evento foi organizado pelo PET MEC Geografia tendo como tutor o professor Dr. Mirlei Fachini Vicente Pereira. Neste sentido, partimos da compreensão de Humboldt como um cientista que enxergava na pesquisa a própria ação quando essa consorciada com a libertação de tudo que possam causar sofrimento O fascínio com a obra de Humboldt na Geografia brasileira é resultado de uma postura acadêmica distante da sociedade. A obra de Humboldt é o resultado de uma postura radical contra a opressão, o racismo e a violência europeia empreendida aos povos oprimidos em todos os espaços colonizados; assim, esses fundamentos anticolonialistas em Humboldt precisam de ecos na própria Geografia brasileira. O anticolonialismo de Humboldt nos força a pensar uma ciência geográfica comprometida com a práxis transformadora da realidade por meio da destruição de toda forma de opressão.
Estágio Supervisionado na graduação em Geografia: um relato de experiência na educação infantil e nos anos iniciais do ensino fundamental
Authors: Oliveira Gregolate Vítor
Published: January 2021

O presente trabalho objetiva narrar as experiências escolares na educação infantil e nos anos iniciais ocorridas a partir das atividades desenvolvidas no Estágio Supervisionado I, no primeiro semestre do ano de 2018, como disciplina obrigatória do curso de licenciatura em Geografia do Instituto de Geografia da Universidade Federal de Uberlândia.
Uma percepção através do estágio supervisionado: a alfabetização ecológica aplicada a educação infantil
Authors: Nunes de Carvalho Letícia
Published: January 2021

O presente trabalho busca apresentar um exemplo empírico de aplicação eficiente da Educação Ambiental em uma escola da rede privada de ensino em Uberlândia-MG a partir de observações realizadas pela discente durante a prática de estágio supervisionado I, disciplina obrigatória para a formação docente do curso de graduação em Geografia da Universidade Federal de Uberlândia.
A Relevância da Obra de Simon Kuznets para o Debate sobre Distribuição de Renda desde o Pós-Segunda Guerra
Authors: Mansor de Mattos Fernando Augusto
Published: January 2021

O objetivo do artigo é tomar como referência a obra de Simon Kuznets para descrever aspectos importantes do debate sobre desigualdade econômica e distribuição de renda nos países desenvolvidos desde 1945. A primeira seção, baseada em Kuznets (1955), expõe seu modelo com simulações dos efeitos de mudanças de estrutura produtiva e de emprego sobre o perfil distributivo. A segunda apresenta o debate sobre distribuição de renda após 1980, quando ocorre a “reversão” da Curva de Kuznets. Na terceira, destaca-se o “debate do 1% mais rico”, que incorpora aspectos políticos para compreender a recente expansão da desigualdade nas economias desenvolvidas no século XXI. As conclusões apontam a relevância e atualidade de sua obra para o debate sobre distribuição de renda e desigualdade econômica.
Foucault in/moralista
Authors: Morey Miguel
Published: January 2021

1975 es el año en el que, con la publicación de Vigilar y castigar, Foucault propone un modelo de análisis microfísico del poder que viene a desplazar gravemente los análisis políticos habituales; también es éste el año en el que, en España, la muerte del dictador Franco va a acarrear cambios políticos cruciales, como es sabido. La recepción de estos análisis en nuestro país, antes que en las aulas de las facultades de Filosofía, corrió primeramente a cargo de otros grupos universitarios de trabajo (arquitectos, pedagogos, psicólogos, psicoanalistas y psiquiatras, juristas…), y también por algunos movimientos sociales de carácter alternativo. En los encuentros de trabajo que tuvieron lugar con varios de estos grupos, las dificultades que bloqueaban la correcta inteligibilidad de su trabajo eran muy diversas. Es en este contexto que surge la figura del in/moralista, como una vía de acceso al conjunto de gestos elementales en los que su discurso se sustenta.
Claves hermenéuticas para el análisis de los artículos sobre Irán de M. Foucault
Authors: Grijalba Uche Miguel
Published: January 2021

El presente texto pretende, a través de la lectura de los artículos sobre la revolución de Irán de M. Foucault, establecer unas claves de interpretación que nos sirvan como defensa de la posición de su pensamiento. En primer lugar, es necesario conocer la primera clave que es la existencia de una voluntad general del pueblo iraní de no ser gobernados del modo como venían siendo. En segundo lugar, se realiza un análisis del concepto gobierno islámico y su malinterpretación por los intelectuales, sobre todo franceses, de la época. En tercer lugar, destacar la importancia de la religión chiita como normalizadora y aglutinadora de la identidad del pueblo, que se enfrenta a los ideales de modernización, laicismo y nacionalismo propuestos por el Sha. Y, por último, la noción de espiritualidad política que surge de los conceptos anteriores y que conlleva no sólo la trasformación radical del país tras la sublevación, sino la auténtica conversión del sujeto.
Para una filosofía política del cuerpo: estética de la existencia y razón erótica
Authors: Moreno Pestaña José Luis
Published: January 2021

En este artículo analizo aportaciones de Michel Foucault y Antoni Domènech, relacionadas ambas con una filosofía política del cuerpo. Para ello estudio sus acercamientos respectivos a la ética clásica, ya sea como una estética de la existencia o como una razón erótica que se opone a una razón inerte. Posteriormente, y tras confirmar sus concomitancias, propongo completarlos con una lectura de El banquete de Platón. Finalmente ejemplifico cómo podría funcionar este programa analizando la conformidad y la resistencia contra la imposición de una ortodoxia corporal.
Michel Foucault: el ejercicio de la escritura como praxis de transformación de sí
Authors: Frau Buron Pablo
Published: January 2021

Michel Foucault aportó diferentes perspectivas sobre su propio trabajo. Así, en un principio, consideró sus libros como «cajas de herramientas». Más tarde, empezó a concebirlos como explosivos, para al final de su trayectoria intelectual abandonar esa perspectiva instrumental de sus trabajos y reconocer el ejercicio de la escritura como una praxis de transformación de sí mismo. Este estudio examina esas distintas perspectivas con el objeto de aportar un criterio a la hora de evaluar los usos actuales del trabajo de Foucault.
RISKY BEHAVIOR AS A FORM OF AUTOAGGRESSION IN ADOLESCENTS. THEORETICAL AND PRACTICAL ASPECTS
Authors: Grigoreva Aleksandrina Andreevna
Published: January 2021

Risky behavior is considered in constructive and destructive aspects. The constructive aspect consists of adaptation to the dynamics of modern life. The destructive aspect is about the desire for danger, adventure, that leads to a threat to health and mental health. The problem of risky behavior as a manifestation of autoaggression is particularly relevant in the period of adolescence from 10 to 16 years. About 70 % of adolescent deaths are caused by risk-taking. Aim. The purpose of this work is to study the concepts of risky behavior, its types and prevention. Results. Risky behavior is a form of deviant behavior if it does not meet the standards adopted in a particular society at a certain time and involves an objective danger to the individual. In this regard, this behavior is considered as one of the manifestations of autoaggression. Adolescent risky behavior is caused by a number of biological, psychological, social, and spiritual factors. From an existential perspective, risky behavior is a choice made without reference to the value of one's own life. A teenager's perception of risk is associated with overcoming the fear of death, trying to take control of the situation. The types of autoaggressive risky behavior include ignoring traffic rules, offenses, casual sexual relations and unprotected sex, as well as the use of psychoactive substances. Conclusion. Adolescent risky behavior is a normative phenomenon of age, which under the influence of a number of adverse factors is modified into autoaggressive forms. Autoaggressive risky behavior is a way to regulate the fear of death and existential anxiety. This destructive behavior allows the adolescent to experience a surrogate sense of self-actualization: “I was able”, “I coped”, “I am successful”, which later forms a special way of responding to difficult life situations – addressing the topic of death as a way out of the crisis. An integral part of prevention of self-injurious, risk-taking behaviors of adolescents needs to be existential and personalized approach.