bluuebunny/crossref_metadata_2025 huggingface dataset:
Geostatistical analysis of spatial variability of the liquefaction potential – Case study of a site located in Algiers (Algeria)
Authors: Bouguerba Salah Eddine , Zandagui Djawad , Benhchilif Souad
Published: June 2021

The city of Algiers (Algeria) is a highly seismic area, and therefore, soil liquefaction poses a major concern for structures resting on sandy soil. A campaign of 62 static penetration tests or cone penetrometer tests (CPT) was carried out on a site located in the commune of Dar El Beïda in Algiers. The soil Liquefaction Potential Index (LPI) values were assessed, for each borehole, based on the simplified procedure of Seed and Idriss. On the other hand, the geographic information system and geostatistical analysis were used to quantify the risk of soil liquefaction at the studied site. It is worth mentioning that the (LPI) was taken as a regionalized variable. In addition, the experimental variogram was modeled on the basis of a spherical model. Also, the interpolation of the LPI values in the unsampled locations was performed by the Kriging technique using both isotropic and anisotropic models. Kriging standard deviation maps were produced for both cases. The cross-validation showed that the anisotropic model exhibited a better fit for the interpolation of the values of the soil liquefaction potential. The results obtained indicated that a significant part of the soil is liable to liquefy, in particular in the northwestern region of the study area. The findings suggest that there is a proportional relationship between the risk of liquefaction and the increase or decrease in seismic acceleration.
CONTRIBUIÇÕES DA PSICOLOGIA ESCOLAR PARA AS PRÁTICAS INCLUSIVAS
Authors: ALVES Adaradandara André , MOL Dalva Alice Rocha
Published: June 2021

A educação inclusiva tem foco na cidadania, em que o processo amplia a participação de todos os estudantes nos estabelecimentos de ensino regular. A prática inclusiva propõe-se receber todas as pessoas, sem restrições dentro do ambiente escolar, independentemente da sua condição física e/ou psicológica, pois todos têm o direito de ter acesso ao sistema de ensino. O trabalho do psicólogo escolar é preparar os profissionais envolvidos, oferecer apoio familiar e suporte à comunidade discente. O artigo teve como objetivo apresentar as contribuições do psicólogo no processo de inclusão escolar. A metodologia utilizada foi a revisão integrativa, com base em artigos publicados entre 2009 e 2019, realizada na Biblioteca Virtual em Saúde (BVS). Assim, os resultados apontam a contribuição do psicólogo no processo de inclusão escolar e indicam as dificuldades encontradas. O psicólogo escolar atua como agente transformador que, através de seus conhecimentos, possibilita a promoção de ações interventivas de respeito às diferenças. Concluiu-se que as contribuições do psicólogo escolar no processo de inclusão dependem do seu embasamento teórico e de um ambiente escolar que permita que o profissional faça suas intervenções, buscando a valorização das potencialidades do indivíduo e a diminuição dos riscos do fracasso na escola.
 
EDUCATIONAL PSYCHOLOGY CONTRIBUTIONS TO INCLUSIVE LEARNING
 
ABSTRACT
Inclusive education focuses on citizenship in which the process expands the participation of all students from mainstream educational institutions. Inclusive learning proposes to welcome all people, with no restrictions in the school environment, regardless of their physical and/or psychological condition, since everyone has the right to be granted access to the education system. The role of the educational psychologist is to prepare the professionals involved, and provide support for either the families or the student’s community. This paper aims at presenting the psychologist’s contributions to the inclusive learning process. It is an integrative review, based on articles published between 2009 and 2019, at the Virtual Health Library (VHL). Thus, the results validated the contribution of the psychologist to the process of inclusive learning and indicated the difficulties encountered. The educational psychologist acts as a transformative agent that, through his knowledge, promotes interventional actions regarding their differences.  It was concluded that the contributions of the educational psychologist to the inclusive process depends on their theoretical background and a school environment where their interventions are warranted, pursuing the appreciation of the individual’s potential, and reducing their risk of failure at school.  
 
Descriptors: School. Inclusion. Educational Psychology.
Phylogenetic analyses and genomic variation of the 2019-nCoV
Authors:   Department of Microbiology University of Health Sciences Lahore, Pakistan & Center for Biotechnology and Microbiology University of Swat, Pakistan, Haq Faiz Ul , Saleem Sidrah , Imran Muhammad , Ghazal Ayesha , Ahmad Kashif , Roman Muhammad , Rahman Saeed
Published: June 2021

There is a rising global concern about the SARS CoV-2 as a public health threat. Complete genome sequence have been released by the worldwide scientific community for understanding the molecular characteristics and evolutionary origin of this virus. Aim of the current context is to present phylogenetic relationship and genomic variation of 2019-nCoV. Based on availability of genomic information, we constructed a phylogenetic tree including also representatives of other coronaviridae, such as Middle East respiratory syndrome, severe acute respiratory syndrome and Bat coronavirus. The phylogenetic tree analysis suggested that SARS CoV-2 significantly clustered with bat SARS like coronavirus genome, however structural analysis revealed mutation in Spike Glycoprotein and nucleocapsid protein. However our phylogenetic and genomic analysis suggests that bats can be the reservoir for this virus. Lack of forest might be the fact in association of bats with human environment. It is also difficult to study on bats due to absence of proper reagent and availability of few species for research. We confirm high sequence similarity (>99%) among sequenced SARS CoV-2 genomes, and 96% genome identity with the bat coronavirus, confirming the notion of a zoonotic origin of SARS CoV-2.
Glucocorticoids: Boon or Bane-An assessment of safety proϐiling of steroids in a tertiary care hospital
Authors: Sadhana N Holla
Published: June 2021

Glucocorticoids are used in therapy empirically, but undesirable effects occur with large doses or prolonged administration. The aim of the study is to assess the pattern of adverse drug reactions of glucocorticoids in a tertiary care hospital. A retrospective analysis of adverse drug reactions (ADRs) following administration of glucocorticoids was conducted in the ADR monitoring center, Department of Pharmacology, Kasturba Medical College, Manipal. Clinical and treatment data were collected from the patient case records in the suspected adverse drug reaction reporting form as per the World Health Organization guidelines.  ADRs were assessed for Causality, Preventability and Severity using WHO causality assessment scale, Modified Schumock and Thornton’s scale and Hartwig’s severity scale, respectively. 100 ADRs were observed in 85 patients, with 51% males and 49% females. Prednisolone (53%) was the most common drug responsible for ADRs, followed by betamethasone (9%) and dexamethasone (8%). Hyperglycemia (34%) was the most common ADR, followed by cutaneous adverse reactions (32%). Acne (20%) was common among them. Over 86% reactions were categorized "possible". Among ADRs (91%) treated, only 16 % recovered. About 39% of cases were "probably preventable". The majority of ADRs (72%) were moderate in “severity”. Given the number and severity of side effects, the institution of glucocorticoids requires careful consideration of the relative risks and benefits in each patient.
Writing Research Article in English: Bottlenecks for Scholars and Faculties
Authors: M SARALA SHOBINI
Published: June 2021

Rao, C. S. (2018). English is the language accepted globally for academic Research. It is the choice for many scholarly publications and journals. It is the official language for academic and scientific world of research. It is undoubtedly used for writing research papers and scientific articles by academicians and researchers. English used for academic writing is entirely different than the English which has been used for teaching.
The necessity of English knowledge for the multilingual scholars for publishing their research papers in reputed journals
Authors: E SATHEESH KUMAR
Published: June 2021

Rao, C. S. (2018). English is the language accepted globally for academic Research. It is the choice for many scholarly publications and journals. It is the official language for academic and scientific world of research. It is undoubtedly used for writing research papers and scientific articles by academicians and researchers. English used for academic writing is entirely different than the English which has been used for teaching.
Online Teaching With M-Learning Tools in the Midst of Covid-19: A Reflection Through Action Research
Authors: Q. Huynh Minh , Khatiwada Eraj
Published: June 2021

Aim/Purpose: In the midst of COVID-19, classes are transitioned online. Instructors and students scramble for ways to adapt to this change. This paper shares an experience of one instructor in how he has gone through the adaptation.

Background: This section provides a contextual background of online teaching. The instructor made use of M-learning to support his online teaching and adopted the UTAUT model to guide his interpretation of the phenomenon.

Methodology: The methodology used in this study is action research through participant-observation. The instructor was able to look at his own practice in teaching and reflect on it through the lens of the UTAUT conceptual frame-work.

Contribution: The results helped the instructor improve his practice and better under-stand his educational situations. From the narrative, others can adapt and use various apps and platforms as well as follow the processes to teach online.

Findings: This study shares an experience of how one instructor had figured out ways to use M-learning tools to make the online teaching and learning more feasible and engaging. It points out ways that the instructor could connect meaningfully with his students through the various apps and plat-forms.

Recommendations for Practitioners: The social aspects of learning are indispensable whether it takes place in person or online. Students need opportunities to connect socially; there-fore, instructors should try to optimize technology use to create such opportunities for conducive learning.

Recommendations for Researchers: Quantitative studies using surveys or quasi-experiment methods should be the next step. Validated inventories with measures can be adopted and used in these studies. Statistical analysis can be applied to derive more objective findings.

Impact on Society: Online teaching emerges as a solution for the delivery of education in the midst of COVID-19, but more studies are needed to overcome obstacles and barriers to both instructors and students.

Future Research: Future studies should look at the obstacles that instructors encounter and the barriers with technology access and inequalities that students face in online classes.
El rol del docente en la intervención psicopedagógica con diagnóstico clínico tardío de dislexia infantil congénita
Authors: Mederos Mollineda Katiuska , Escariz Borrego Liliam , Vargas Véliz Sonia , Ron Vargas María Elena
Published: June 2021

La dislexia es un trastorno neuropsicológico con una clínica especifica caracterizada por dificultades en el procesamiento fonológico y el dominio de la relación fonema - grafema. Se describe el caso clínico de una escolar de 7 años de edad con antecedentes de retardo en el desarrollo psicomotor (primeras palabras a los 4 años de edad con lentitud en el aprendizaje y ritmo lento para aprender nuevas palabras). No se detectan datos significativos al examen físico, fondo de ojo y agudeza visual normal y electroencefalograma negativo, por lo que se solicita resonancia magnética de cerebro donde se aprecia menor volumen en el área de broca izquierda con asimetría de la cisura de Silvio. Con estos hallazgos se realiza evaluación neuropsicológica diagnosticándose dislexia congénita. Se comenzó con el programa de lectoescritura dos sesiones semanales con ejercicios de fono articulación, concienciación fonológica y habilidades visoespacial durante 6 meses logrando mejoría en su aprendizaje. Se concluye que es importante realizar una evaluación neuropsicológica precoz, así como aplicar un tratamiento con intervención multidisciplinaria para lograr un acertado aprendizaje en estos escolares mediante un programa orientado hacia el entrenamiento fonológico, aspecto disfuncional en el que se sustenta la dificultad lectora. Siendo fundamental el rol del docente en el aula de clase debido a que es el primero en detectar las dificultades específicas de aprendizaje en el niño, permitiendo abordar sus necesidades desde el inicio, con el fin de ofrecer apoyo adicional y enseñanza especializada que contribuirá a mejorar sus habilidades de manera individual para un eficiente desarrollo de lenguaje oral y escrito.
Síntesis verde de nanopartículas de Plata (AgNPs) utilizando ajo (Alliun Sativum L) explorando su actividad antimicrobial y catalíticas
Authors: Villa Sánchez Fabiola Elena , Moncayo Molina Wilson Edwin , Alvarado Aguilar Marina Chanena , Leal Chantong Alfredo Antonio , Daza Barcia Deillys Dayanna
Published: June 2021

La fabricación de nanopartículas mediante el uso de síntesis verde se realiza debido a sus amplias aplicaciones en diferentes campos, como la ingeniería biomédica, la agricultura y la alimentación.  En este trabajo se utilizó el extracto de bulbo de ajo andino Allium sativum, que contiene compuestos organosulfurados siendo los de mayor importancia la alicina, alixina, dialil sulfuro y dialil disulfuros, aminoácidos sulfurados, lípidos, alcaloides, diterpenos, carbohidratos, saponinas, como agente reductor y estabilizantes. La presencia de nanoparticulas de plata AgNPs en solución se identificó por un espectrofotómetro de UV-VIS 4802 double beam spectrophotom. El tamaño de las nanoparticulas está en el rango de 40 a 60 nm. La forma esférica y la naturaleza cristalina de los AgNPs fueron confirmadas por DSL-ISO 13321. La optimización del proceso se realizó variando el volumen del extracto del bulbo de Allium sativum L., las concentraciones de nitrato de plata, el pH, la temperatura y el tiempo de reacción. Los AgNPs biosintetizados exhibieron actividad antibacteriana contra las cepas bacterianas E. coli, Staphylococcus aureus y Aspergillun niger. Tiene propiedades desinflamatorias y antitumorales.
Valoración del metabolito de HAPs en trabajadores. Estudio de caso en un laboratorio de monitoreo ambiental
Authors: Miranda Cabrera Marcia , Miranda Cabrera Catalina , Villota Garcia Verónica
Published: June 2021

Los Hidrocarburos Aromáticos Policíclicos (HAPs) son compuestos orgánicos, formados por pirólisis o durante la combustión incompleta de materia orgánica y de forma natural formando parte de la composición de combustibles fósiles. Pueden ingresar al organismo a través de varias vías como la respiratoria, la gastrointestinal y la dérmica; y muchos están considerados como carcinógenos y/o mutagénicos es así que su exposición merece una atención especial. Los Técnicos del Laboratorio de Monitoreo Ambiental (LABSSA), se encuentran expuestos a las emisiones de las fuentes fijas durante la ejecución del monitoreo de estos gases procedentes de las chimeneas, por esta razón este estudio se enfocó en el monitoreo de la calidad de aire respirable en el ambiente laboral durante las actividades de exposición. Para determinar la presencia de los HAPs en el organismo de los Técnicos se determinó el metabolito 1-HOP en la orina, disponiendo de muestras de orina durante cinco días consecutivos de exposición. Para la cuantificación del 1-HOP se optimizó un método analítico por HPLC. Los resultados del 1-HOP se compararon con los índices biológicos de exposición indicados por la Superintendencia de Riesgos del Trabajo (IB de 2 ug/g de creatinina, 1 umol/mol creatinina), lo cual permitió establecer si la salud de los trabajadores se encuentra afectada o no. Además, para corroborar si la salud de los trabajadores se ve afectada, en cada día de exposición se evaluaron parámetros clínicos como: tensión arterial, oxigenación, hematocrito y creatinina.
NORMAS DE PUBLICACIÓN
Authors: Novillo Nibia
Published: June 2021

NORMAS DE PUBLICACIÓN
Weather and Lockdown Compliance
Authors: Ganslmeier Michael , Van Parys Jonathan , Vlandas Tim
Published: June 2021

The effectiveness of containment measures depends on both epidemiological and sociological mechanisms, most notably compliance with national lockdown rules. Yet, there is growing discontent with social distancing rules in many countries, which is expected to intensify further during summer. Using a highly granular dataset on compliance of over 105,000 individuals in the United Kingdom (UK), we find that compliance with lockdown policies tends to be high in the overall population, but that specific segments of society are substantially less compliant. Our findings show that warmer temperatures decrease non-compliance with governmental guidelines of individuals who are male, divorced, part-time employed, and/or parent of more than two children. Thus, as long as heard immunity through vaccination is not achieved and new strains demand containment measures to remain in place, understanding the individual determinants of non-compliance behaviour in different seasons of the year will remain important for policymakers to design effective policies in the future.
Neuronal ceroid lipofuscinosis therapeutics
Authors: Dowaidar Moataz
Published: June 2021

Several therapies for neuronal ceroid lipofuscinosis (NCL) are currently being explored, although not all of them are effective against all subtypes (notably, CLN4, CLN9, CLN12, CLN13, and CLN14 diseases have no treatment studies). The majority of these medicines in development are potentially disease-modifying in the sense that they may slow or even stop disease progression. Nevertheless, only a small number of them are expected to even partially reverse the condition, and total reversal is extremely rare. Early identification and treatment will become even more critical as these damage-limiting therapies become more widely available. Despite the fact that some treatment possibilities are in the works, we must continue to deal with these serious diseases, which impose a significant load on patients, their families, and healthcare professionals. Patients' quality of life will improve as a result of future medicines, and their families will have reason to be hopeful.
Carbon nanotubes have enormous potential in gene therapy
Authors: Dowaidar Moataz
Published: June 2021

One of biomedicine's most popular uses of Carbon Nanotubes (CNTs) is drug/gene delivery. CNT may carry drugs such as docetaxel (DTX), doxorubicin (DOX), methotrexate (MTX), paclitaxel (PTX), and gemcitabine (GEM). The human body has not yet assessed CNTS and its use in therapeutic applications is still in its early stages. Carbon nanotubes' intrinsic properties have spurred a flurry of research endeavors. Before using them in therapeutic applications, a full knowledge of their pharmacological and toxicological features is required." In recent decades, nanomaterials have attracted interest from scientists, maybe more than any other material type. In recent years, nanomedicines have grown in popularity. Nanomedicine has been popularized in recent years. It has become one of research's fastest-growing fields. Researchers have tried to use carbon nanotubes as possible candidates for various biological applications. They can be swallowed to deliver medicines and genes through passive or active absorption mechanisms. Cell internalization of CNTs is a complicated process that can have both beneficial and negative repercussions. Despite recent breakthroughs in nanotoxicology, scientists have been unable to anticipate carbon nanotubes' behavior and biokinetics precisely. There is still a need to assuage anxieties about the possible harmful effects of C NT applications in medicine, and we must all work together to conduct better studies to provide conclusive answers, experts say. Benefits and disadvantages should be evaluated against those of other drug delivery methods, since each has its own pros and downsides.
Nonviral gene delivery vectors for transfection of the CAR gene for CAR-T cell therapy
Authors: Dowaidar Moataz
Published: June 2021

The introduction of the CAR gene via retrovirus is the most widely used and most successful technique for CAR-T cell therapy. However, the limitations and risks associated with viral gene therapy continue to motivate the development of nonviral gene delivery technologies that are potentially safer, less expensive, and quicker. In terms of safety and efficacy, electroporation has emerged as the most promising non-viral technology, albeit more optimization testing and clinical trials are required before it can be directly compared to retroviral CAR gene delivery techniques. But these findings suggest that non-viral gene delivery to T cells (and other related cells, such as natural killer cells) is feasible and is quickly emerging as a viable alternative to CAR-T cell therapy and other gene therapies.
Potential HIV gene therapy strategies
Authors: Dowaidar Moataz
Published: June 2021

The CCR5 null genotype generation has been a main focus in the HIV gene therapy industry. The presence of the X4 tropic virus, mobilization of HSPCs, the quality of the cells for manipulation, and gene editing efficiency appear to be the main obstacles in translating this technique. Unintended off-target cleavage is a key problem in CRISPR/Cas9 editing. With the development of small molecule expansion methods for cord blood HSPC, it would be advantageous to modify CCR5 in cord blood cells and expand them for transplantation. The generation of engraftable HSPCS from iPSCs would be an ideal technique for HSCC gene therapy.The haplotype-characterized iPSC would be the donor for many patients, and it could be a commercially available product. The 32 C CR5 homozygous people had no elevated mortality risks according to whole-exome sequencing and whole-genome genotyping, according to CCR 5 positive people, and had no higher mortality risks compared to those who were HIV positive. Recent advances in gene editing, such as non-viral delivery of Cas9 ribonucleoproteins, incorporation of a 3X-nuclear localization signal into spCas9, and use of HiFi Cas9 with chemically modified sgRNAs, can be combined with recent advances in transplantation. Infusing modest doses of gene modified primitive HSPC fractions indicated by CD34 + CD90 + CD45RA-, which can engraft better, is another option for lowering the cost of gene therapy.
The Role of Digitalization in MSME Marketing
Authors: Fitri Rohmadina Sabila
Published: June 2021

Digital technology has a big role in MSME business and marketing today. The use of digital technology in the digital marketing concept is a combination of online and strategies offline, where marketing withmedia online must also be supported by offline content that has a human-to-human touch so that it becomes relevant to be able to create engagement with consumers. Digital technology can facilitate MSME business development in Indonesia. With optimal use of digital technology, MSMEs can build businesses and achieve big profits with small capital. Digital technology can also help MSMEs expand their business reach, from what was previously only around the environment where the MSMEs stand to become even wider (Krisnawati, 2018).
DESAIN PEMBELAJARAN MATEMATIKA DENGAN KONTEKS PERMAINAN KULI BIA PADA MATERI FAKTOR PERSEKUTUAN TERBESAR DAN KELIPATAN PERSEKUTUAN TERKECIL
Authors: Sohilait Emy
Published: June 2021

The learning process of the concept of greatest and Least which are the prerequisites of the greatest common divisor and the least common multiple in class IV SD Inpres 2 Waipo is carried out with the teaching paradigm that is, using T tables, multiples, and not using student thought conjectors in find concepts or material. This underlies researchers to design learning designs using Realistic Mathematics Education (RME) with the context of the kuli bia game as a starting point. The purpose of this study is to produce a learning trajectory and determine the impact of the use of learning designs on the mathematical knowledge construction process. Design research was chosen to achieve this goal which consists of three stages: preliminary design, teaching experiment, retrospective analysis. The results of the study found that the kuli bia game provides an important role in supporting learning and increases learning motivation, able to understand the material based on the learning trajectories generated, provides a variety of strategies in solving problems both at the situational stage, models of, models for and formal stages, the implementation of RME with the context of the kuli bia game on the material is running optimally, the response of students and teachers is positive and effective management of learning in the classroom.
RNAi-based gene therapy provides a wide variety of applications. Safe, biodegradable nano delivery vectors are still needed
Authors: Dowaidar Moataz
Published: June 2021

The considerable influence of siRNA and shRNA in controlling CRC by activating apoptosis and preventing CRC formation has been proven in vitro and in vivo research. Furthermore, the combined actions of inhibitors and RNAi-mediated gene knockdown may result in novel cancer therapy approaches.RNAi-based approaches give a wide range of prospective applications and a high degree of freedom to manipulate heretofore "unhackable" targets. However, in clinical investigations, RNAi medications are a major challenge to overcome. Furthermore, compared to other cancers such as melanoma, colon cancer has seen fewer clinical trials due to its tissue complexity. While new delivery strategies and materials are being investigated to increase distribution efficiency, randomized controlled trials must be done before treatment recommendations utilize RNAi. Safe, biodegradable and biocompatible NP delivery systems are still needed. Repeatable and simple batch production techniques for clinical trials and regulatory evaluations need to be created. Since unmodified siRNAs have limited cell uptake, they must be conjugated or complexed with suitable carrier systems. Furthermore, by combining siRNAs with adaptive and biocompatible nonviral carriers, the short half-life of siRNAs may be regulated due to their quick plasma and cell cytoplasm breakdown. Clinical trials should be explored with improved techniques to enhance RNAi medication encapsulation in lipid-based NPs such as liposomes or biodegradable polymers such as PLGA, cellular uptake and endosomal escape in mCRC cells. Advances in nanotechnology and medicinal chemistry may help address these issues, and adoption of RNAi-based therapeutics may increase.Another crucial part of employing RNAi-based therapeutics is finding suitable targets. Besides knowing target genes and pathways for CRC advancement, understanding modifying genes that compensate for the effect of target gene loss function and the degree of gene silence necessary is crucial.
Strategies for treating multiple sclerosis with gene therapy
Authors: Dowaidar Moataz
Published: June 2021

As biomedicine progresses, more laboratories are moving their attention to clinical research, and a significant breakthrough has been made in the treatment of multiple sclerosis (MS). Modern disease therapy, on the other hand, is primarily concerned with alleviating clinical symptoms and, where possible, improving function. Patients with MS are more likely to develop depression, cognitive and behavioral issues, and possibly permanent disability as the disease progresses.There is no doubt that the current treatment strategy is insufficient. We require a more ambitious strategy that incorporates a variety of therapies in order to maximize synergy. It is possible that a combination of symptomatic medicines (such as those for cramps, fatigue and depression), rehabilitation, and specific MS treatments will give the best chance of halting the course of MS in some people. Such research, on the other hand, would be time-consuming, expensive, and challenging.
MSMEs and Digitali in Covid-19
Authors: Kencanasari Fidelia Rahayu
Published: June 2021

The number of MSMEs that are starting to grow very much in Indonesia, assisted by the sophistication of technology that is increasingly developing makes MSMEs very able to get the public market. The convenience that is obtained through online shopping is more felt by the people of Indonesia, making swords now starting to compete to collaborate with various existing platforms to keep getting customers and customers don't run to other stores. Digitalization has proven to be able to support the economic recovery program due to Covid-19, making the central, provincial, district and city governments including BUMN and BUMR carry out development and empowerment efforts for MSMEs in Indonesia.
uas pi
Authors: Bahalwan Aldhi Nurman
Published: June 2021

UAS PI UMKM Aldhi nurman
The combination of unique biomolecules and nanoparticles has shown successful gene therapy treatment approaches for non-small cell lung cancer treatment
Authors: Dowaidar Moataz
Published: June 2021

Using nanotechnology-based drug delivery systems can solve some of the drawbacks of conventional cancer treatment, such as non-specific targeting, solubility difficulties, and poor entry of chemotherapeutic drugs into cancer cells. Over the last two decades, a combination of unique biomolecules and nanoparticles has shown successful treatment approaches for Non-small cell lung cancer (NSCLC) treatment. Targeted gene delivery employing lipid, polymer or metal-based nanoparticles showed positive in vivo and in vitro experimental findings with therapeutic efficacy. Gene therapy has shown enhanced transfection efficiency and targeting potential for various NSCLC cell lines when delivered locally or systemically. Despite this, there are a number of barriers to nanoparticle-mediated gene therapy, including ensuring the stability of biomolecules and nanoparticles during delivery, managing their biodistribution, and reducing the possible adverse effects of nanoparticles. These difficulties must be handled before clinical trials begin. Evaluation of therapeutic efficacy as well as inspection criteria for nanoparticles in gene therapy must be devised to widen the use of nano-gene therapy in cancer treatment. Advanced models, algorithms, and simulations to anticipate nanoparticles' biodistribution, design, and kinetics will be needed in the future to decrease the barrier to nanoparticles in clinical trials. Using new technologies and software, nanoparticles with increased selectivity, increased loading capacity, long circulation periods and effective influx into the vascular endothelium and the blood brain barrier may be generated. Nanoparticles having advanced qualities such as biodegradability, non-toxicity, and non-immunogenicity will facilitate the application of nanotechnology in gene therapy, leading to breakthroughs for cancer patients and in biomedical research. Formulation of unique techniques, notably using a combination of anticancer drugs, must be further researched for effective gene delivery-based therapies.
Charge-alteration-based approaches can address the evolving needs of nucleic acid-based gene therapy, charge reversal techniques are also promising
Authors: Dowaidar Moataz
Published: June 2021

Recent approvals of RNAi-based medications have rekindled interest in the industry, possibly strengthening the power of the therapeutic platform. Many groundbreaking research endeavors have offered new carrier architectures for carrying nucleic acid payloads. Because nucleic acids are charged negatively, utilizing complementary positively charged compounds sounds like a smart approach. The presence of such a cationic charge in the delivery vector, however, is a serious problem, increasing cytotoxicity. Charge-alteration-based approaches can address the evolving needs of nucleic acid-based therapies. Medication delivery platforms have become significantly smarter and safer.The research focuses on exciting recent advancements in management-switching technology. This study summarizes some of these fascinating possibilities, written by authors with special attention to the underlying physics of charge conversion processes. Charge reversal techniques are fairly new and are still in the early development phases. Translating such ideas would require significant investigation, including studies of safety, efficacy, and immunogenicity using relevant disease models.
Necessary Condition Analysis (NCA) has either low specificity or low sensitivity
Authors: Sorjonen Kimmo , Melin Bo
Published: June 2021

Objective: To assess the ability of Necessary Condition Analysis (NCA) to achieve its originally stated goal to detect if a condition is necessary but not sufficient for an outcome as well as its more recently stated goal to detect non-randomness in the association between two variables. The performance of NCA was compared with the performance of ordinary linear regression analysis. Results: For its originally stated goal, NCA exhibited low specificity. For its more recently stated goal, NCA displayed low sensitivity. Ordinary linear regression analysis is superior to NCA for detecting non-random associations. There does not seem to exist any compelling reasons to use the significance test in NCA rather than ordinary linear regression analysis.
The Future of Intelligence: The Central Meaning-Making Unit of Intelligence in the Mind, the Brain, and Artificial Intelligence
Authors: Demetriou Andreas , Golino Hudson , Spanoudis George Charilaos , Greiff Samuel , Makris Nikolaos
Published: June 2021

This paper focuses on general intelligence, g. We first point to broadly accepted facts about g: it is robust, reliable, and sensitive to learning. We then summarize conflicting theories about its nature and development (Mutualism, Process Overlap Theory, and Dynamic Mental Field Theory) and suggest how future research may resolve their disputes. A model is proposed for g involving a core meaning-making mechanism, noetron, drawing on Alignment, Abstraction, and Cognizance, perpetually generating new mental content. Noetron develops through several levels of control: episodic attentional inferential truth epistemic control in infancy, preschool, childhood, adolescence, and adulthood, respectively. Finally, we propose an agenda for future brain, assuming a brain noetron, and artificial intelligence research, assuming an artificial noetron, that might uncover the underlying brain mechanisms of g and generate artificial general intelligence.
Moral orientations in psychology: contrasting theoretical perspectives
Authors: Wiley James Christopher
Published: June 2021

BackgroundThe relational development systems (RDS) metamodel embodies a newly recognized scientific paradigm that stands in contrast to the nature-nurture split. It suggests that the bidirectional relationship between an organism and its environment must be the central focus of scientific inquiry.Main bodyRDS theorists suggest scientists have a moral obligation to benefit human kind. However, the potential for interventions that appear efficacious to simultaneously instigate an undesirable outcome suggests that moral clarity might not always exist in scientific practice. Contrasting RDS perspectives with life history theory highlights a pertaining disparity in approaches.ConclusionWhile the RDS metamodel posits many premises necessary to contemporary research, it may not yet be pragmatic to impose moral obligation on the sciences.
Development and Initial Validation of Two Brief Measures of Left-wing Authoritarianism: A Machine Learning Approach
Authors: Costello Thomas H , Patrick Christopher
Published: June 2021

Although authoritarianism has predominantly been studied among political conservatives, authoritarian individuals exist on both “poles” of the political spectrum. A 39-item multidimensional measure of left-wing authoritarianism, the Left-wing Authoritarianism Index, was recently developed to extend the study of authoritarianism to members of the far-left. The present study coupled a fully automated machine learning approach (i.e., a genetic algorithm) with multidimensional item response theory in a large, demographically representative American sample (N = 834) to generate and evaluate two abbreviated versions of the Left-wing Authoritarianism Index. We subsequently used a second community sample (N = 477) to conduct extensive validational tests of the abbreviated measures, which comprise 25- and 13-items. The abbreviated forms demonstrated remarkable convergence with the full LWA Index in terms of their psychometric (e.g., internal consistency) and distributional (e.g., mean, standard deviation, skew, kurtosis) properties. Further, this convergence extended to virtually identical cross-measure patterns of correlations with 14 external criteria, including need for chaos, political violence, anomia, low institutional trust. In light of these results, the LWA-25 and LWA-13 scales appeared to function effectively as measures of LWA.
Book Review: Filsafat Manusia Untuk Psikologi (Human Philosophy For Psychology)
Authors: Purwanto Tasya Melinia , Pandin Moses Glorino Rumambo
Published: June 2021

The book focuses on developing human philosophical perspectives in psychology which analyzed and reflected on scientific references related to philosophy, human philosophy, and Indonesian psychology development based on Indonesian human philosophy. This book is intended for anyone from any circle who wants to study human philosophy from a psychological perspective, designed for the psychology and philosophy community, and a reference for human philosophy courses majoring in psychology for both students and lecturers. In the development of psychology in Indonesia, human philosophical, scientific works related to psychology are still quite limited. Therefore, the author hopes the book will enrich the perspective of human philosophy in psychology in Indonesia.
Another Origins Debate: Settler Colonialism in Early Virginia History
Authors: Tsukada Hiroyuki
Published: June 2021

William and Mary Quarterly recently initiated an origins debate concerning settler colonialism in America in their discussion of the applicability of that framework to early America. Settler colonialism is a type of colonialism, specifically characterized as dispossession of indigenous people of their land. In respect to British North America, the beginnings of settler colonialism originate in Virginia, where British colonists came into conflict with native people over land not long after their arrival.
Book Review: Learner Teachers, Not Ordinary Teachers (Building Professional Teacher Competencies Inspiring and Moving Generations) (Guru Pembelajar, Bukan Guru Biasa (Membangun Kompetensi Guru Profesional Lintas Generasi yang Menginspirasi dan Menggerakkan))
Authors: Amanina Asma , Pandin Moses Glorino Rumambo
Published: June 2021

Teachers are the intermediaries who deliver the relay sticks of Indonesian progress to the millennial generation of the 21st century. The progress of the nation can be obtained by qualified human resources (HR). Human resources (HR) can be obtained if education in the country is adequate and organized. The role of teachers, in general, is as an educational task, including educating, teaching, and training. In technological advances, many learning media can be obtained quickly, but the role of teachers remains irreplaceable. The book Visible Learning by researcher John Hattie (2013) mentions that one of the five determining factors of student success in achieving achievement is the role of teachers. The magnitude of the role of the teacher shows that the quality possessed by a teacher must be equal. The professionalism of teachers is assessed from various aspects, one of which is the attitude of a teacher when teaching. The attitude of a professional teacher reflects the values contained in Pancasila. Pancasila is still the most appropriate philosophy and paradigm both in reality and ideologically to control Indonesia. This book aims to show the sides of qualified and professional teachers to become outstanding teachers for millennials in the global age. Based on the title and the purpose, the author shows that teachers in Indonesia can become professionals in the millennial generation. The teacher in question starts from kindergarten to upper secondary level. So this book will be helpful for teachers and prospective teachers at any level who want to increase their potential. In this book, the author conveys several new things, including the character that teachers must-have in the era of disruption and the industrial era 4.0. Then, the author also showed the paradigm of Multidimensional and multicultural Indonesian Education. This new information and sciences are indeed beneficial for readers.
Filsafat Dan Kearifan Dalam Agama Dan Budaya Lokal (Philosophy and Wisdom In Religion And Local Culture)
Authors: HELONIA ANTEA , Pandin Moses Glorino Rumambo
Published: June 2021

The book Filsafat Dan Kearifan Dalam Agama Dan Budaya Lokal is written to improve the quality of research in the field of philosophy and the values of local wisdom, besides being able to describe, analyze, synthesize, interpret, evaluate, and reflect on various kinds of theories and practical problems in a philosophical perspective. Able to solve various problems in society philosophically. This book is also able to communicate philosophical ideas in writing and solve problems in social life.This book is a form of dissemination. Part of the results of research conducted by lecturers at the Faculty of Philosophy UGM who have diverse interests and expertise with the aim of being enjoyed by a wide audience of readers. Thus, academic thoughts and recommendations on various scientific, national and humanitarian issues resulting from research activities can be socialized and can be used as a reference and inspiration for various interested parties. Starting from academics, researchers, bureaucracy, to the general public.The book presents a variety of new information for a wide audience which is packaged attractively through various aspects such as the relationship between philosophy and religion and philosophy with local culture. We know that philosophy with religion and local culture is very contradictory, but this book can answer that philosophy can link up with local culture and religion.The book needs to be reviewed because the information presented in this book is very interesting to review. Why is that? Because this book explores and explores local wisdom that exists in local culture and religion through a philosophical approach. A philosophical approach to scientific development can be done by exploring and developing philosophical aspects in the various branches of philosophy and science.
BOOK REVIEW: MATINYA EPIDEMIOLOG: EKSPANSI MODAL DAN ASAL-USUL COVID-19 (DEAD OF EPIDEMIOLOGY: CAPITAL EXPANSION AND ORIGIN OF COVID-19)
Authors: Adha Febianti Nurul , Pandin Moses Glorino Rumambo
Published: June 2021

The book entitled "The Death of Epidemiologists: Capital Expansion and the Origin of Covid19" has a total of 258 pages with very dense content and many sources of writing. This book waswritten by Rob Wallace in 2020, then translated by A. Faricha Mantika, and published by IndependentPublishers the following year. Rob Wallace is an evolutionary biologist and public healthphylogeography currently working as a researcher at the Institute for Global Studies at the University ofMinnesota. Rob Wallace is also the author of Big Farms Make Big Flu, Dead Epidemiologist, and thesoon-to-be-published Revolution Space, all three published by the Monthly Review Press. Based on thetable of contents, the book contains 12 chapters, two of which are chapters 1 and 4 containinginterviews conducted by Rob Wallace. The purpose of writing the book is an attempt by the author to answer the main question,namely, how did the origin of covid-19? Furthermore, the writing of this book also aims to describehow the economic system causes the death of epidemiologists. Why is the denial and justification of thevirus their way of the ruling class to exist? And why is it impossible for the ruling class to play a role instopping this radical change and the virus? Therefore, the purpose of writing the book is to explain howthe origin of the covid-19 virus and how epidemiologists submit and die by the expansion of capitalbelonging to the ruling class, as well as explain the political tools of "justification and denial" by theruling class to maintain the status quo.
Efeito do Extrato da casca da Aroeira (Schinus terebinthifolia Raddi) sobre os parâmetros bioquímicos em ratos diabéticos.
Authors: Gonçalves Yasmynn , Da Silva Luana Aparecida , Selicani Mariany Aparecida , Santos Oliveira Carlos Henrique , Correa Salles Bruno Cesar , Bitencourt Santos Gérsika
Published: June 2021

O Diabetes mellitus (DM) é uma das principais causas de morbidade e mortalidade no mundo, por isso os recursos financeiros investidos no tratamento são altíssimos tanto para o governo quanto para as famílias que lidam com a doença. Dessa forma, estudos estão utilizando plantas medicinais para promoção e prevenção dessa patologia, pois estas apresentam constituintes químicos com atividade hipoglicemiante e antioxidante atribuídos a vários mecanismos de ação. O presente projeto avaliou o efeito do Extrato Hidroetanólico da casca da aroeira (Schinus terebinthifolia Raddi) sobre os parâmetros bioquímicos de ratos Wistar diabéticos do tipo 1, induzidos por Aloxano (130 mg/kg), por um período de 4 semanas pelo método de Gavagem, depois do tratamento ocorreu o sacrifício dos mesmos. Após essas semanas de tratamento os resultados obtidos através de uma análise estatística utilizando o teste de Scott-Knott e/ou Turkey revelaram que o extrato da casca da aroeira apresentou uma marcante diminuição nos valores da glicemia pré-prandial. Já no perfil lipídico indicou uma notória melhora, também foi demonstrado uma função protetora nas enzimas de função hepática e por fim um resultado satisfatório no marcador de função renal, em todos esses casos foram comparados o grupo diabético tratado com a casca entre o diabético não tratado. Conclui-se que a Schinus terebinthifolia Raddi) apresenta efeito normoglicemiante, podendo relatar também um efeito hepato protetor e renal, com mais pesquisas e estudos essa planta pode ser considerada como uma nova alternativa terapêutica ou tratamento complementar ao DM.
Les plantes nocives pour la grossesse
Authors: Hammiche V.
Published: June 2021

Pendant la grossesse, les femmes se plaignent, le plus souvent, de nausées, de constipation, de jambes lourdes, de nervosité et d’insomnie, et parfois, d’infection urinaire, d’hémorroïdes. Les maux (de l’hiver) hivernaux, comme rhume, grippe et angine, ne les épargnent pas. Les femmes enceintes, conscientes des risques auxquels lesmédicaments les exposent, se tournent, souvent, vers des médecines dites douces comme la phytothérapie. Au Maghreb, il est facile de se procurer les plantes médicinales dont on a besoin, soit dans les boutiques des herboristes, soit au marché où les étals en offrent une très grande variété. Contrairement à une idée très répandue, la phytothérapie est loin d’être toujours inoffensive. La prudence s’impose, donc, comme avec n’importe quel médicament.