bluuebunny/crossref_metadata_2025 huggingface dataset:
Nanosuspension: A Novel Approach to Improve the Solubility, Bioavailability and Pharmacokinetics of Poorly Soluble Drugs
Authors: Tupe Arpita , Mankar S.D.
Published: October 2023

Solubility is an essential factor for drug effectiveness, independent of the route of administration. Poorly water soluble drugs show major problems for drug formulation. Many conventional methods exist to address the issues of poor solubility and bioavailability, but they have many drawbacks. Nanotechnology is employed to address the issues related to these traditional methods for improving solubility and bioavailability. Pharmaceutical nanosuspension is a very finely colloid, biphasic, dispersed, solid drug particles in an aqueous vehicle, size below 1µm, without any matrix material, stabilised by surfactants and polymers, prepared by suitable methods for Drug Delivery applications, through various routes of administration such as oral, topical, parenteral, ocular and pulmonary routes. This article covers the advantages, disadvantages, properties, preparation of nanosuspension by bottom up technology, top down technology, melt emulsification, emulsification- solvent evaporation and supercritical fluid with their advantages and disadvantages, evaluation, and their drug delivery applications.
Basics and Recent Advances in Peptide and Protein Drug Delivery
Authors: Mankar S.D. , S. Jadhav Bhagyashri , N. Kale Awantika
Published: October 2023

While the peptide and protein therapeutic market has developed significantly in the past decades, delivery has limited their use. Despite the fact oral delivery is preferred, most are currently delivered intravenously or subcutaneously due to degradation and limited absorption in the gastrointestinal tract, absorption enhancers, enzyme inhibitors, carrier systems and stability enhancers are being studied to make easier oral peptide delivery. As well, transdermal peptide delivery avoids the issues of the gastrointestinal tract, but also faces absorption limitations. Due to proteases, opsonisation and agglutination, free peptides are not systemically stable without modifications. This review discusses oral and transdermal peptide drug delivery, focusing on barriers and solutions to absorption and stability issues. Methods to increase systemic stability and site-specific delivery are also discussed.
Association between coa gene and enterotoxin gene in S. aureus from dairy cattle in Brazil
Authors: VALMORBIDA Mylena Karoline , CARDOZO Marita Vedovelli , ALMEIDA Camila Chioda de , PEREIRA Natália , DEZEN Diogenes , ASSIS Marcella Zampoli de , VERBISCK Newton Valério , GRIEBELER Eliete , PIZAURO Lucas José Luduverio , ÁVILA Fernando Antônio de
Published: October 2023

Staphylococcus aureus is an important agent in bovine mastitis, and some specific virulence factors may be implicated in this disease. Therefore, this study aimed to investigate the importance of the presence of coagulase, superantigens, genotypic and phenotypic resistance, and pulsotypes in 65 S. aureus isolates from bovine clinical and subclinical mastitis in the Southeast of Brazil. A high correlation was observed between the genes coa and see, as well as between the sei and the see and seh. High resistance rates were observed for penicillin (95.4%), tetracycline (89.2%), cefoxitin (86.1%), oxacillin (84.6%), erythromycin (84.6%), clindamycin (84.6%), chloramphenicol (81.5%), ceftriaxone (80.0%), and ampicillin (80.0%). Analysis of antimicrobial resistance profiles showed that 89.2% of isolates were multi-drug-resistant. No mecA-positive S. aureus isolates were detected. It was observed that seven isolates were resistant to all the β-lactam tested while being susceptible to cefoxitin, which could be indicative of borderline methicillin resistance in S. aureus⁠. High genetic diversity with no specific virulence profile being predominant was observed. Thus, this study observed a high correlation between the coa and enterotoxins genes, and demonstrates that there is no predominant pulsotype causing intramammary infection and that there is a high rate of antibiotic resistance in S. aureus isolates from dairy farms in the southeast regions of Brazil.
Factors influencing kombucha production: effects of tea composition, sugar, and SCOBY
Authors: DARTORA Bruna , SANT’ANNA Voltaire , HICKERT Lilian Raquel , FENSTERSEIFER Mariana , AYUB Marco Antônio Zachia , FLÔRES Simone Hickmann , PEREZ Karla Joseane
Published: October 2023

Kombucha is a functional beverage that lacks studies toward standardization of process parameters; thus, the present work aims to evaluate the effect of sucrose content, initial SCOBY mass, and tea composition on several characteristics of the final beverage. For this purpose, a factorial design was performed, and the effect of the three variables was statistically evaluated. All kombuchas were within Brazilian regulation standards (higher than 2.5 and lower than 130 mgEq/L) and can be classified as non-alcoholic beverages. Kombucha yield ranged from 87.3% to 96.4%; SCOBY growth, from 41.11 to 62.08%; turbidity, from 108 to 421.5 NTU; acetic acid, from 3.78 to 5.33 mg/mL; glycerol, from 0.25 to 0.52 mg/mL; and ethanol content, from 1.90 to 3.21 mg/mL. Results showed that kombucha yield, pH, and SCOBY growth were significantly influenced by the SCOBY mass; acidity was greatly affected by the tea composition; kombucha’s turbidity was significantly affected by the sucrose content and the interaction of the sugar content and tea composition; and glycerol, alcohol, and acetic acid were not affected by the parameters evaluated. Results bring science-based information about this global trending beverage, seeking high quality and standardization.
Computational Engineering based approach on Artificial Intelligence and Machine learning-Driven Robust Data Centre for Safe Management
Authors: G Senthilkumar , P Rajendran , Y Suresh , N Herald Anantha Rufus , Tanguturi Rama chaithanya , Solanki Rajdeep Singh
Published: October 2023

This research explores the integration of Artificial Intelligence (AI), specifically the Recurrent Neural Network
(RNN) model, into the optimization of data center cooling systems through Computational Engineering. Utilizing
Computational Fluid Dynamics (CFD) simulations as a foundational data source, the study aimed to enhance operational
efficiency and sustainability in data centers through predictive modeling. The findings revealed that the RNN model,
trained on CFD datasets, proficiently forecasted key data center conditions, including temperature variations and airflow
dynamics. This AI-driven approach demonstrated marked advantages over traditional methods, significantly minimizing
energy wastage commonly incurred through overcooling. Additionally, the proactive nature of the model allowed for the
timely identification and mitigation of potential equipment challenges or heat hotspots, ensuring uninterrupted operations
and equipment longevity. While the research showcased the transformative potential of merging AI with data center
operations, it also indicated areas for further refinement, including the model's adaptability to diverse real-world scenarios
and its management of long-term dependencies. In conclusion, the study illuminates a promising avenue for enhancing
data center operations, highlighting the significant benefits of an AI-driven approach in achieving efficiency, cost
reduction, and environmental sustainability.
CHEMOMETRIC ASSISTED UV SPECTROPHOTOMETRIC METHOD FOR QUANTIFICATION OF EMTRICITABINE AND TENOFOVIR DISOPROXIL FUMARATE
Authors:   Department of pharmaceutical Chemistry, AISSMS College of pharmacy, (Affiliated to Savitribai phule pune University), Kennedy Road, Near R.T.O., Pune - 411 001, Maharashtra, India, Gandhi Santosh V. , Shinde Smruti C.
Published: October 2023

The aim of this study was to verify the ability of the UV spectrophotometric method for the simultaneous determination of emtricitabine and tenofovir disoproxil fumarate in tablet dosage form using the principal Component Regression (pCR) and partial Least Squares (pLS) multivariate calibration methods. Double beam UV-Vis spectrophotometer (Jasco V-730) with 1 cm quartz cell with 1 nm data interval and scanning speed of 400 nm min -1 was used in the study. the optimized wavelength range selected was 225-275 nm. the data obtained was processed using Unscrambler X (10.5) (64bit) software. The developed models showed good results over the concentration range of 6-36 μg mL -1 for tenofovir disoproxil fumarate and 4-24 μg mL-1 for emtricitabine with co-relation coefficient greater than 0.995 and % RSD less than 2%. the accuracy studies show % recovery within limits. The method was validated as per ICH Q2(R1) guideline.
Study on the Development Path of Lingbi Shadow Theater in the Age of Self-media
Authors: Jin Panpan , Liu Shuang
Published: October 2023

As an intangible cultural heritage of Anhui Province, how to better inheritance and development is an important issue that Lingbi shadow theatre is facing now. This project mainly explores how Lingbi shadow theatre can make use of the fast and convenient self-media platform to reach the public in the age of self-media. Through the field investigation method, literature reading method and other research methods, we study the artistic characteristics and cultural connotation of Lingbi Shadow Opera, and analyse the dilemmas and reasons it is facing nowadays. According to the communication methods and advantages of self media, combining with the current development situation of Lingbi shadow theatre and the humanities of Lingbi County, we discuss how to combine Lingbi shadow theatre with self media to give full play to its cultural value, economic value, social value and so on. It is proposed to combine traditional media, new media and self-media, everyone can be a non-heritage communicator, and develop cultural and creative products, in order to expand the audience of Lingbi shadow theatre and achieve the common development of self-media and Lingbi shadow theatre. This study is based on the national policy of protecting intangible cultural heritage, the inheritance and development of Lingbi shadow puppet theatre, not to cater to the public to destroy its own cultural characteristics, and to strengthen the supervision of its output culture while using self media. In conclusion, through the results of this study, new vitality is injected into Lingbi shadow theatre, and it is hoped to provide some references and lessons for the inheritance and development of other intangible cultural heritages in China.
Five Microsoft Excel Features to Enhance Financial Analysis
Authors: Lyons Bridget
Published: October 2023

The Microsoft Excel program contains hundreds of useful features but it can be daunting to identify appropriate applications. In this paper I demonstrate how five features can enhance financial analysis. The features are applied in a capital budgeting context but could also be utilized in other financial contexts including forecasting, valuation and working capital management. The features examined are: the choose function to create scenarios, data validation to restrict selections, data tables for sensitivity analysis, conditional formatting to highlight key results and scenarios under consideration and concatenation to string together text and formula results.
A Virtual Trading Project for the Derivative Securities Course
Authors: Henry Stephen
Published: October 2023

In this paper, I present a simulated trading project for the undergraduate Derivative Securities course which allows students to realistically trade both Futures and Option contracts. The project makes use of the Virtual Trading tool provided on the Chicago Board Options Exchange website, which processes virtual trades in real time using actual market data. Student response to the project's first implementation in Fall 2008 has been overwhelmingly positive. I provide Likert-style survey results describing students' perceptions of various aspects of the assignment, and identify directions for potential future modifications.
Using Mortgage Rates to Explain Risk Premiums in an Introductory Finance Course
Authors: Moon Kenneth , Tanner Glenn
Published: October 2023

Devising an effective way to teach interest rate determinants and help students understand various risk premiums is an essential part of any introductory finance course. Unfortunately, because these topics are commonly taught in conjunction with the introduction of bonds, students often become confused while trying to simultaneously learn new terminology and concepts related to bond pricing. In this paper, we describe a more student friendly approach to teaching interest rate determinants. We believe students gain a better understanding of risk premiums when related to loan types they are already somewhat familiar with. Specifically, this paper describes how to use a simple comparison of various mortgage rates to more clearly explain concepts such as default risk, interest rate risk, and liquidity risk. This approach focuses students' attention on the concepts at hand rather than confusing them with multiple high level applications at one time.
A Method for Teaching the Black-Scholes Option Pricing Model Using Excel
Authors: Johnson Steve , Stretcher Robert
Published: October 2023

One of the most important concepts in modern finance practice and education is option pricing. The Black-Scholes model of option pricing is possibly the most commonly-used model. This paper presents an implementation of the Black-Scholes model of option pricing that includes graphs of the option value, the intrinsic value, and the time value. These graphs are dynamic, allowing the user to change the value of the volatility of underlying asset returns, time to maturity, and the risk-free rate. The user can also see how price of an option changes with movements in the underlying asset price. By illustrating both option prices and the components of option prices (intrinsic and time value) over a range of underlying asset prices, students can more easily visualize the effects of the drivers of option prices.
Creating a Capital Budgeting Analysis Model in Excel
Authors: Collins Jessica , Irons Robert , Weigand Robert
Published: October 2023

N/A
México: energías renovables
Authors: Esparza Rosiles Aurora
Published: October 2023

La generación de energías renovables en México determina la forma de utilizar e implementar energías limpias para el sector energético, principalmente para el eléctrico, es necesario realizar y analizar los avances que ha tenido el país respecto a la transformación de cambiar el rumbo y mirar hacia la recuperación del medio ambiente. ¿Cómo se logra transformar la generación de electricidad que existe actualmente en México para convertirlas en energías renovables? En este artículo solo atenderemos la propuesta de la transformación del sector eléctrico a través de norma jurídica, con el fin de establecer que el estado mexicano tiene la responsabilidad de la administración, aplicación y control de generar energía renovable. Nuestro objeto de estudio tiene como fin analizar los avances, propuestas y retrocesos que ha tenido el sector energético, en la representación institucional de la Secretaria de Energía (SENER). Es interesante analizar la Constitución Política de los Estados Unidos Mexicanos, en los artículos 26, 27, 28 y 29, respectivamente y las normas supletorias, pues son la base para considerar la importancia de conjuntar la ciencia, la tecnología y el derecho, como un conjunto de elementos que permiten atender la demanda de la población y el beneficio que se tiene para el medio ambiente.
Hacia la definición de un nuevo orden político y económico internacional
Authors: Gómez Cárdenas Raúl
Published: October 2023

Este artículo describe y analiza los acontecimientos y tendencias que construyeron el nuevo orden político y económico internacional vigente en nuestros días: desde las recomposiciones de poder, resentimientos y procesos de recuperación económica entre las naciones involucradas, que caracterizaron a la primera posguerra; la posterior bipolaridad militar, ideológica y económica que distinguió al periodo de la segunda posguerra, hasta la tendencia a la regionalización y la cooperación internacional, que actualmente caracteriza al mundo. Todo esto ha tenido en un gradual lugar consenso de los ciudadanos al interior de los países, que exigen mayor acceso a la toma de decisiones de gobierno, el respeto a los derechos humanos y al medio ambiente, así como el arreglo pacífico de los conflictos.
La contribución transdisciplinaria en la novela psicológica
Authors: Cardozo Brum Myriam
Published: October 2023

Literatura y psicología, con algunos aportes de las ciencias sociales, se unen en un esfuerzo transdisciplinario en la escritura y estudio de la novela psicológica. Se trata de un subgénero que caracteriza a sus personajes en forma compleja, ambivalente y hasta contradictoria, y se concentra en su vida interior, enfatizando inquietudes, sentimientos, temores, pasiones o conflictos. Su mayor desarrollo se produjo en Europa en los siglos XIX y XX, con algunos muy relevantes en Estados Unidos de América y Japón. La novela latinoamericana, de carácter psicosocial, se concentra en la segunda parte del siglo XX e inicios del XXI. El objetivo del presente artículo es valorar el aporte transdisciplinario de la novela psicológica, a través de sus principales obras, ubicándose geográfica y temporalmente. Para ello se utiliza el método de reconstrucción histórica y de localización geográfica, así como el análisis de su contenido.
A study on self-esteem and life satisfaction among adolescents aged 14–19 years attending adolescent-friendly health clinic, Medical College, Kolkata
Authors: Manna Nirmalya , Mullick Tanjib , Mazumdar Sayantan , Das Sudipta
Published: October 2023

Background: Quick physical, social, and cognitive changes occur during adolescence. An individual’s overall good opinion of themselves is referred to as self-esteem and is associated with undesirable outcomes such as depression, substance abuse, and antisocial behavior. “Life satisfaction” is the cognitive assessment of a person’s overall quality of life. Adolescent life satisfaction is correlated with a wide range of psychological, behavioral, interpersonal, and intrapersonal factors. With the prevalence of mental health problems rising globally, it is crucial to assess risk variables.

Aim and Objectives: The aim of the study was to study sociodemographic characteristics, level of self-esteem, and life satisfaction among the participants and to find out relationships between variables.

Materials and Methods: An observational, cross-sectional study was done over a period of 2 months in an adolescent-friendly health clinic of Medical College, Kolkata, among middle and late adolescents. Participants were selected by systematic random sampling and a pre-designed pre-validated data collection form was used to interview them. Statistical Program for the Social Sciences software, version 20.0, was used to analyze the data.

Results: Responses were taken from 129 participants among which 80 belonged to middle adolescence and 49 to late adolescence. About 37.20% of the population were males and the rest were females. Twenty-two of the study participants admitted to substance use in different forms of tobacco. Forty-one (31.80%) participants have low self-esteem, and 50 (38.76%) participants have different levels of dissatisfaction in life.

Conclusion: A sizable portion of the participants struggled with low self-esteem and various levels of life dissatisfaction. Participants with mixed families reported being happier with their lives than those with nuclear families.
Understanding infection-related glomerulonephritis in adults: Clinical profiles and prognostic factors
Authors: P Marsook , Akbar Ashna
Published: October 2023

Background: Infection-related glomerulonephritis (IRGN) has witnessed evolving epidemiological patterns. While pediatric IRGN has been extensively studied, adult IRGN remains less explored. Differentiating between IRGN and similar clinical presentations of glomerulonephritis in adults is crucial for optimal management and predicting prognosis.

Aims and Objectives: The aim of this study was to analyze the clinical, pathological, and outcome patterns in adults diagnosed with IRGN. The study also aimed to identify the significance of kidney biopsy, including electron microscopy, in diagnostic and prognostic evaluation. Furthermore, the research sought to recognize factors influencing poor renal outcomes in adult IRGN.

Materials and Methods: This was a retrospective analysis of 115 adults diagnosed with IRGN. Data related to clinical presentation, preceding infections, laboratory parameters, and histopathological findings were meticulously collated. Renal biopsies were examined with light microscopy, immunofluorescence, and electron microscopy. Outcomes were categorized as complete recovery, persistent urinary abnormalities, persistent renal dysfunction, end-stage renal disease (ESRD), and mortality at 1-year follow-up.

Results: The mean age of the cohort was 46.06 years, with a male predominance. Streptococcus pyogenes and Staphylococcus aureus were the leading causative organisms. Seasonal trends pointed to a peak incidence in July. Notably, 28.7% of the patients had diabetes mellitus. At presentation, 80% had acute kidney injury, with 25% necessitating dialysis. Hypocomplementemia was observed in the majority, with 87% having a reduced C3 level. Electron microscopy revealed a mean glomerular basement membrane thickness of 438 nm ± 178.05, with 55% showing subepithelial humps. The crescent formation was present in 11.3% of biopsies. Treatment modalities included antibiotics (33%), antihypertensive (51.3%), and steroids (18.3%). At the 1-year mark, 51.3% achieved complete recovery, 15.7% had persistent urinary anomalies, and 6.1% progressed to ESRD. Two patients succumbed within the year. Advanced age, diabetes, crescents, interstitial fibrosis, tubular atrophy, underlying diabetic glomerulosclerosis, and subepithelial humps were predictors of poor renal outcomes.

Conclusion: In adults, the epidemiology, complications, and long-term outcomes of IRGN markedly differ from the pediatric population. Due to the similarity in clinical presentations of various glomerulonephritis, kidney biopsy in adult patients suspected of IRGN becomes pivotal for accurate diagnosis and prognostication.
Perkawinan Adat Paru Dheko di Ende Ditinjau dari Hukum Islam
Authors: M. Sali Jakaria , Iskandar  , Munandar Aris
Published: October 2023

Perkawinan Paru Dheko adalah salah satu tradisi perkawinan yang terdapat di Kecamatan Nangapanda Kabupaten Ende. Tradisi perkawinan ini bermula dari kedua orang yang berlainan jenis yaitu laki-laki dan perempuan yang menjalin hubungan asmara dan ingin menikah,, tapi keinginan tersebut tidak direstui oleh pihak keluarga wanita. Ketidak setujuan pihak perempuan berasaskan pada perbedaan stratifikasi sosial, perbedaan ekonomi dan hamil di luar nikah. Dampak Paru Dheko ini bagi anak perempuan adalah ia akan dicoret dari susunan kekeluargaan, dan tidak dianggap anak oleh pihak keluarganya sendiri. Penelitian ini merupakan penelitian lapangan field research. Hasil penelitian menunjukan bahwa Lari Ikut dalam tinjauan hukum Islam  bertentangan dengan hukum islam, karena berpatokan pada hadist Nabi tentang wali yang diriwayatkan oleh imam Thabrani yang menyatakan bahwa “Tidak sah suatu pernikahan kecuali akad nikah itu dilakukan oleh walinya dan disaksikan oleh dua orang saksi yang adil (HR Thabrani)” . Dengan demikian, dapat diisimpukan bahwa Lari Ikut (Paru Dheko) yang dilaksanakan di daerah Ende bertentangan dengan hukum Islam jika mengacu pada versi ulama-ulama madina berdasarkan hadis tersebut.
Revitalisasi Perbuatan Hukum Dalam Akad Pembiayaan Murabahah Perbankan Syariah
Authors: Abdurrauf Mursal
Published: October 2023

Pembiayaan murabahah merupakan produk penting bank syariah guna mendistribusikan dana kepada para nasabah perbankan tersebut. Pembiayaan ini tentu mengacu fatwa Dewan Syariah Nasional Majelis Ulama Indonesia (DSN-MUI) dan Standar Produk Perbankan Syariah. Perspektif fiqh, marabahah sebagai transaksi jual beli dimana barang mesti ada di antara bank dengan nasabah, tetapi secara praktik adalah penyaluran dana karena bank sebagai mediator yang tidak mempunyai barang, sehingga bank bersandar pada akad wakalah untuk menyalurkan dana dan mendapatkan keuntungan dari jual beli tersebut. Berdasarkan penelitian sebelumnya bahwa pembiayaan murabahah bil wakalah masih tidak selaras dengan prinsip syariah, bahkan implementasinya tercemar oleh moral hazard, dimana penyaluran dana tanpa ada jual beli barang sebagaimana tertulis dalam akad. Penelitian ini adalah penelitian hukum dengan metode deskriptif menganalisis bahan hukum primer, sekunder, dan tersier. Dengan menggunakan pendekatan ushul fiqh, penulis melakukan content analysis terhadap norma hukum pembiayaan murabahah. Penelitian ini mengalisis legal standing subjek hukum, hubungan hukum dan menentukan perbuatan hukum sebagai sebuah akad pembiayaan murabahah. Kebaruan dari penelitian ini adalah rukun syarat pembiayaan murabahah terdiri dari empat pihak dan sebelas perbuatan hukum. Revitalisasi dari penelitian ini yaitu DSN-MUI dan OJK perlu membuat legal standing pelaku pembiayaan, bukan hanya bank dan nasabah, serta memasukkan sebelas perbuatan hukum sebagai rukun atau syarat baru dari akad pembiayaan murabahah, agar sesuai dengan prinsip syariah.
ALTERAÇÕES NO TRANSPORTE HIDROVIÁRIO EM TEMPOS DE PANDEMIA NA TRAVESSIA BELÉM-MARAJÓ
Authors: Fiedler Luan Carlos Paiva , Tobias Maisa Sales Gama , Da Silva Thayana Lima , De Paiva Junior Humberto
Published: October 2023

A pandemia afetou diretamente o transporte hidroviário, com interrupções nas operações, redução de lotação nas viagens e alterações na demanda, exigindo a reorganização do serviço. Assim, este estudo contribuiu para a identificação das alterações no transporte hidroviário, tendo como caso a ligação Belém – Porto do Camará, na Ilha do Marajó.  Os dados foram obtidos de uma pesquisa de campo embarcada e no Terminal Hidroviário de Belém, envolvendo os períodos: antes, durante e depois da COVID 19. Dentre os resultados, observou-se alterações do comportamento e percepção de qualidade por parte dos usuários, o que evidenciam a necessidade de investimento no setor.
Національні економічні інтереси України: концепти змін інформаційної економіки та активізація регіонального кластероутворення
Authors: Коляденко С. В.
Published: October 2023

Статтю присвячено актуальним питанням розробки, обговорення та реалізації національних економічних інтересів України в умовах активізації розвитку інформаційної економіки, системного поширення регіонального кластероутворення. Визначено ключові напрями та особливості змін національних економічних інтересів у вигляді управлінських концептів, що відображають особливості проблем, конфліктних станів національного інформаційного простору за умов ведення війни, перспектив відновлення іт-бізнесу в постмілітарному просторі з урахуванням процесів євроінтеграції, інформаційного прогресу. Обґрунтовано цільове призначення управлінських концептів, як інструменту відображення змін інформаційної економіки, врахування процесу кластероутворення на рівні регіонів, галузей та підприємств. Актуальними та востребуваними рекомендовано визнавати національні економічні інтереси в прямому поєднанні з сферами впливу: інформаційним ринком, іт-сектором, смарт-економікою. Наведено класифікацію національних інтересів України та обґрунтовано відповідні напрями стимулювання розвитку інформаційної економіки, активізації процесу кластероутворення на базі хмарних сервісів. Сформовано бачення подальшої перспективності формування кластерів підприємств на основі єдності послуг хмарних сервісів на національних платформах співпраці. Обґрунтовано національний інтерес формування мультихмарних сервісів, як умови інформаційної безпеки українського бізнесу.
Promotion of well-being in work and interpersonal relationships: A scoping review of goals and meaning interventions
Authors: Liversage Christelle , Wissing Marié P. , Schutte Lusilda
Published: October 2023

With the demanding pace and challenges of the world today, there is an amplified need to identify ways of attaining well-being in the context of the workplace and relational domains of life. As work and interpersonal relationships are key domains of life where people set goals and find meaning in their search for well-being, interventions towards the promotion of well-being in these domains have become a strategic and critical priority to meet the demands of an everchanging world. Interventions to enhance well-being through goals and /or meaning in various domains of life are dispersed across disciplines, highlighting the need for a comprehensive overview of the current state of the art to advance its progress. This study aimed to explore through a scoping review existing literature on interventions to enhance goals and meaning to promote well-being in the life domains of work and interpersonal relationships. Using specific search terms in each of these domains, a literature search of scientific articles was conducted via various search platforms and databases. Thirty-eight articles were identified, scrutinized, and with the aid of clearly defined inclusion and exclusion criteria a final number of 27 articles extracted. No interventions were found on the concordance of goals and meaning in either of the two domains. Goals and meaning interventions, in both domains, used diverse strategies, leading to various hedonic and eudaimonic outcomes. Findings per study are described in terms of target groups, intervention strategies and outcomes. Through the indication of a major gap in research regarding interventions aiming at the alignment or harmonisation of goals and what is meaningful to people, this study points to further possibilities for research on the development and evaluation of interventions that aim to enhance the alignment of goals and meaning in the work and especially the interpersonal relationships domains.
Artifical Intelligence and Bias: Challenges, Implications, and Remedies
Authors: Min Alfonso
Published: October 2023

This paper investigates the multifaceted issue of algorithmic bias in artificial intelligence (AI) systems and explores its ethical and human rights implications. The study encompasses a comprehensive analysis of AI bias, its causes, and potential remedies, with a particular focus on its impact on individuals and marginalized communities. The primary objectives of this research are to examine the concept of algorithmic bias, assess its ethical and human rights implications, identify its causes and mechanisms, evaluate its societal impact, explore mitigation strategies, and examine regulatory and community-driven approaches to address this critical issue. The research employs a multidisciplinary approach, drawing from literature reviews, case studies, and ethical analyses. It synthesizes insights from academic papers, governmental reports, and industry guidelines to construct a comprehensive overview of algorithmic bias and its ramifications. This research paper underscores the urgency of addressing algorithmic bias, as it raises profound ethical and human rights concerns. It advocates for comprehensive approaches, spanning technical, ethical, regulatory, and community-driven dimensions, to ensure that AI technologies respect the rights and dignity of individuals and communities in our increasingly AI-driven world.
Evaluating the use of Intelligent Irrigation Systems Based on the IoT in Winter Season of Vyas Municipality Ward No-1 and 13 of Nepal
Authors: Pantha Deepak , Koju Dr. Roshan
Published: October 2023

Nepal's agricultural progress seems insufficient, particularly in its hilly regions where inadequate cultivation has led to a trend of people seeking employment overseas. This study investigates the contemporary agricultural landscape, focusing on irrigation management. Despite irrigation not covering all hilly areas, even in irrigated arable lands, efficient water management remains a challenge. Traditional methods result in water wastage, while modern techniques optimize water use, preventing agricultural issues caused by excess water. This research delves into the potential, difficulties, and prospects of IoTbased irrigation in Nepal's hilly regions. The primary aim is to assess the reality of IoTdriven irrigation in Nepal's hilly regions. The primary aim is to assess the reality of IoTdriven irrigation in the hilly area Vyas Municipality's ward no-1 and 13. Over a six-month test perod, around 95% of water wastage was curbed through IoT irrigation, as compared to manual methods. Pilot test demonstrated the positive impact of reduce water wastage on agriculture. Additionally, a 90-day comparative study of plant growth, weight, and development was conducted. analysis of challenges, benefits, and investments associated with modern irrigation technology in the hilly areas revealed IoT-based irrigation's significant potential and suitability. This research underscores its pivotal role in modernizing agriculture, enhancing farmer productivity, and stimulating higher yields.
Environmental Impact of Green Marketing in the Present World
Authors: Ramesh S.
Published: October 2023

Green marketing has emerged as a vital strategy for businesses aiming to address environmental concerns and promote sustainable practices. This article explores the environmental impact of green marketing in the present world, focusing on its effectiveness in promoting eco-friendly products, consumer behavior, and corporate sustainability initiatives. Through a review of literature, we analyze ten scholarly articles that shed light on the challenges, opportunities, and potential of green marketing. The research emphasizes the significance of transparent communication, consumer awareness, and regulatory support in harnessing green marketing for positive environmental outcomes. Furthermore, the article discusses the role of businesses, policymakers, and consumers in creating a greener future through sustainable marketing practices.
Doorwerking van onschuld naar niet-punitieve sancties
Authors: Franssen D.J.
Published: October 2023

Doorwerking van onschuld naar niet-punitieve sancties. Annotatie bij CBb 28 februari 2023, ECLI:NL:CBB:2023:86

De rechter kan ontoelaatbare twijfel over de juistheid van een strafrechtelijke uitspraak vaak voorkomen door afdoende verwijzingen naar de verschillende bewijsregimes. Toch kunnen Melo Tadeu-achtige verweren zo nu en dan slagen. In de optiek van de auteur bevatte de procedure die leidde tot de uitspraak van het CBb van 28 februari 2023 de daarvoor benodigde ingrediënten.
Alimentación saludable en población mayor. Análisis cualitativo de las percepciones de personas mayores y profesionales sanitarios (oral)
Authors: Ferran Mercadé Manuel , Alapont Serrano Marina , Iparraguirre Oiartzabal Idoia , Vicente Tolosa Miren Karmele , Lasa Goñi Miren Bittori
Published: October 2023

OBJETIVOS
Analizar las experiencias y creencias en torno a la alimentación saludable de personas mayores. Identificar barreras y facilitadores para promover una alimentación saludable en las personas mayores.

PACIENTES Y MÉTODOS
Se realizaron tres grupos focales (GF) con personas mayores de 70 años y dos GF con personal médico y de enfermería de familia que participaron voluntariamente. Los cinco grupos los dirigió la misma investigadora. Las sesiones tuvieron una duración aproximada de 90 minutos. Se partió de un guion semiestructurado que abordaba los principales aspectos que se querían recoger. Se analizaron los datos cualitativos siguiendo la guía de Krueger. Se transcribieron los discursos tras la ejecución y grabación de los GF. Se hicieron varias escuchas de las grabaciones y lecturas de las transcripciones para identificar temas emergentes.

RESULTADOS
En los GF de mayores, participaron 20 personas mayores de 73-89 años (13 mujeres y 7 hombres). Se identificaron siete temas emergentes: penetración social y popularización del saber médico; a medio camino entre las prácticas tradicionales y las «legítimas»; la figura de la «buena esposa»; la reivindicación de lo natural; la (des) legitimación basada en la experiencia; la (des)preocupación de la salud marcada por la masculinidad tradicional; y el componente social de la alimentación. En el caso de los GF profesionales, participaron 15 profesionales: 8 de enfermería y 7 de medicina (11 mujeres y 4 hombres). Las dificultades identificadas fueron: falta de motivación; malinterpretaciones o falsas creencias; falta de control sobre el proceso de alimentación; factores estructurales: estrategias comerciales o de marketing. Por otro lado, las propuestas fueron: promover huertos urbanos; dinámicas grupales o talleres sobre nutrición y cocina; contar con un(a) nutricionista y disponer de más tiempo; metodologías y formación en habilidades comunicativas.

CONCLUSIONES
Las dificultades identificadas para el cambio de hábitos dietéticos tienen más que ver con la dificultad o incapacidad para cambiar ciertas conductas que con el desconocimiento sobre las pautas recomendadas.

CEI
CEI OSI Donostia. MFM-APM-2019-01.
Papel de la Atención Primaria en el cribado diagnóstico y tratamiento de personas con apnea obstructiva del sueño (oral)
Authors: Olabarrieta Zaro Elena , Comas i Soler Helena , Cairó Corominas Sílvia , Faixeda Vidal Helena , Pinsach Garanger Judit , Obrador Lagares Anton
Published: October 2023

OBJETIVOS
Realizar el cribado de apnea obstructiva del sueño (AOS) de la población atendida por cualquier motivo en Atención Primaria (AP) mediante el test de STOP-BANG.
Mejorar el proceso asistencial del diagnóstico de la apnea obstructiva del sueño, incorporando al personal de enfermería de AP en el diagnóstico y tratamiento de pacientes con apnea del sueño, con el apoyo de una unidad virtual del sueño hospitalaria.

MATERIAL Y MÉTODOS
Estudio descriptivo y transversal en población de entre 30 y 70 años atendida en AP. Se incluyen personas con tres o más puntos en el test de STOP-BANG y se excluyen a las personas con enfermedades graves cardiovasculares y barrera idiomática, así como a personas con estudios de apnea del sueño previos. Variables: edad, sexo, peso, test de STOP-BANG, número de apneas del sueño (índice de apnea-hipoapnea [IAH]). Las variables continuas se describen con la media y su desviación estándar, y las categóricas, mediante la frecuencia absoluta y su porcentaje. Cada paciente firmó consentimiento informado. El estudio fue aceptado por el comité ético correspondiente.

RESULTADOS
Los profesionales de AP realizaron el test de STOP-BANG a 1.290 personas. El personal de enfermería hizo la anamnesis focalizada y la poligrafía respiratoria nocturna a las 986 personas que obtuvieron un test de STOP-BANG ≥ 3. De estas, 608 personas (62%) fueron diagnosticadas de apnea del sueño por la unidad virtual y tratadas con el dispositivo CPAP en AP, 222 personas (22%) fueron derivadas a la unidad del sueño hospitalaria y se dio de alta a 156 (16%) al no tener patología del sueño.

CONCLUSIONES
Aceptación positiva en el proceso diagnóstico y tratamiento de la AOS en AP. Alta sensibilidad de la prueba de cribado STOP-BANG en AP. Se diagnostica y se controla al 62% de las personas con AOS desde su propio centro de AP. Se valida la factibilidad de la AP en el diagnóstico y tratamiento y la mejora del infradiagnóstico de AOS.

CEI
El número de comité ético de investigación (CEI) es 2021.049.
Validación de una versión modificada del PCPI-S para medir atención centrada en la persona en Atención Primaria (oral)
Authors: López Barakaldo Sandra , Respaldiza Berroeta Itxaso , Portugal Martínez Ander , Muñoz González María Cruz , Rogers Heather Lynn
Published: October 2023

OBJETIVOS
Medir la atención centrada en la persona (ACP) autorreportada por profesionales de Atención Primaria (AP) mediante la identificación y validación de un cuestionario.

MATERIAL Y MÉTODOS
Tras revisar la literatura, identificamos el cuestionario Person-Centred Practice Inventory-Staff (PCPI-S; Slater, McCance and McCormack, 2017). De los 59 ítems y 17 subescalas, seleccionamos 10 subescalas con los 33 ítems que mejor reflejaba la ACP en AP. Se utilizó el método de traducción y retrotraducción de la Organización Mundial de la Salud. Es un estudio observacional transversal en AP. Se reclutaron 94 sanitarios (42 médicos y 52 enfermeras), sin abandonos, de cinco centros de salud para completar el cuestionario. Se hizo un análisis factorial exploratorio utilizando el método la factorización de ejes principales y la rotación promax. Las limitaciones son el tamaño reducido de la muestra y el posible sesgo por autorreporte. El estudio recibió la aprobación del comité de ética (CEIC PI2021204).

RESULTADOS
Una solución con cinco factores explicó el 51,7% de la varianza. Para retener un ítem, la carga factorial tenía que alcanzar un punto de corte de 0,40 y sus cargos a otro factor tenían que estar por de debajo de 0,15 puntos menos del valor de su cargo mayor. Se propone una escala de ACP en AP de 21 ítems con 5 subescalas: integración de la perspectiva del paciente como persona (6 ítems), utilización de comunicación empática verbal y no-verbal (6 ítems), autorreflección (3 ítems), ACP basado en la evidencia (4 ítems) y valores y creencias ACP (2 ítems). Las correlaciones entre factores tenían un rango de 0,072-0,539.

CONCLUSIONES
Los resultados indican que tenemos un cuestionario corto autocumplimentado válido para medir la ACP en AP. Sería importante replicar los resultados en muestras más grandes. En estudios posteriores, se podrían revisar las historias clínicas o recoger información sobre ACP en consulta con un observador externo.

CEI
El Comité de Ética de la Investigación con Medicamentos de Euskadi (CEIm-E) aprobó el estudio- CEIC PI2021204.
Direito/educação/educação sexual em uma reflexão teórica sobre os filhos/as de famílias homoparentais na escola
Authors: De Jesus Leidiane Dias , Da Silva Claudionor Renato
Published: October 2023

O presente trabalho nasce da problemática: (qual) ou quais contribuições o Direito pode proporcionar à Educação no enfrentamento ao preconceito aos filhos/as de famílias homoparentais no espaço escolar em que se reafirmam os discursos da família “de bem e estruturada” de natureza heterossexista? O objetivo geral é refletir teoricamente sobre a presença dos filhos/as de casais homoparentais na escola sob o olhar do Direito com contribuições para a gestão e a prática educativa dos/as gestores/as, de docentes, de alunos/as-alunos/as, de pais e responsáveis, de funcionários/as da escola e, por extensão, de toda a sociedade, na construção de uma sociedade igualitária sem preconceitos e discriminações. Utiliza-se a metodologia do Estado da Arte para situar as tendências do tema no interior da área da Educação e Educação Sexual com a presença do ordenamento jurídico envolvido na questão. Os encaminhamentos de resultados e conclusões, da reflexão teórica realizada, apontam para a necessidade, inicialmente, de Projetos Políticos Pedagógicos das unidades escolares que contemplem políticas de acolhimento aos filhos/as de famílias homoparentais o que inclui a formação continuada de professores/as na área da Educação Sexual, na proposta de que haja um convívio saudável e espaço acolhedor, respeitando os filhos/as de famílias homoparentais, com a finalidade de preservar os direitos fundamentais previstos na Carta Magna.
Ensino médio brasileiro: leituras de currículo e conhecimento produzidas em teses e dissertações (1999- 2015)
Authors: Marques Aline Rabelo
Published: October 2023

Este texto tem por objetivo apreender como estão posicionadas as discussões sobre o conhecimento e o currículo para/no Ensino Médio, em dissertações e teses produzidas entre 1999 e 2015. A metodologia deste trabalho está fundada em pesquisa bibliográfica e documental, esta última realizada na base de dados da Biblioteca Digital Brasileira de Teses e Dissertações (BDTD). A operação nesta base de dados orientou-se por uma indagação, isto é, quais as leituras sobre currículo e conhecimento estão sendo produzidas para estudar o Ensino Médio? Vale destacar, que esta operação será analisada com base na Teoria Crítica do Currículo, tendo como hipótese inicial, que as leituras produzidas pelas dissertações e teses identificadas, estejam voltadas para a função, particularmente, prescrita para esta etapa da educação básica, qual seja, preparar para o mercado de trabalho.
Atividades extensionistas para o desenvolvimento de raciocínio computacional no ensino médio
Authors: Sokolonski Ana Carolina , Filardi Vitor Leão
Published: October 2023

Atividades de extensão atraem a participação dos jovens por oferecer aprendizagem complementar. Diversos alunos se candidatam a bolsas nestes projetos. Neste artigo serão descritos três projetos de extensão executados no IFBA - Campus Salvador, que envolveram nove alunos do ensino médio técnico. Os projetos usaram Robótica Educacional, Modelagem de Sistemas, Programação de Computadores e Aprendizagem Baseada em Projetos, para promover o aprendizado do Raciocínio Computacional, culminando em produtos que beneficiaram a comunidade interna e externa do IFBA. No final dos projetos foi possível avaliar a evolução dos alunos, que adquiriram habilidades como a abstração e decomposição de problemas, sistematização de soluções, raciocínio algorítmico, avaliação evolutiva, autocrítica e consenso. Os principais resultados foram: um software de comunicação aluno-professor, um sistema de alarme de incêndio e uma plataforma de ensino de Robótica e Computação (com videoaulas, roteiros e materiais didáticos, além de problemas temáticos para o reforço do aprendizado).
Hepatozoonose canina no Brasil: revisão de literatura
Authors: Zaiden Letícia Caetano , Assis Junior Winicius Gomes , Ramos Elen Tassiane Bauer , Costa Georgia Emilly Soares , Grassi Julia Barbaroto , Tosati Maria Eduarda Correia , Abolis Vitória Breda , Da Silva Lizandra Fernandes
Published: October 2023

A hepatozoonose canina é uma doença do grupo das hemoparasitoses que acomete os cães, causada pelo protozoário Hepatozoon canis, o qual é caracterizado pela capacidade de parasitar os tecidos hemolinfáticos e possui como vetor o carrapato Rhipicephalus sanguineus sensu lato. A transmissão dessa enfermidade ocorre pela ingestão de carrapatos infectados; sua distribuição se relaciona ao vetor e está amplamente difundida no território brasileiro. O ciclo biológico contempla a reprodução sexuada no hospedeiro definitivo (carrapato) e a reprodução assexuada no hospedeiro intermediário (cão). Não possui patogenia claramente elucidada, podendo variar de leve a grave, dependendo das condições do paciente. Os sinais clínicos, assim como a patogenia, também variam, porém os mais comumente relatados são: febre, anorexia, fraqueza dos membros torácicos, corrimento ocular e/ou nasal, e mucosas hipocoradas. Os pacientes infectados possuem alterações laboratoriais, como anemia e leucocitose neutrofílica; o diagnóstico é feito através da detecção de gamontes em esfregaço sanguíneo na microscopia. Possui como tratamento recomendado a associação de dipropionato de imidocarb e doxiciclina, enquanto a prevenção consiste no controle do ectoparasita. Com o presente trabalho, busca-se realizar o levantamento e análise dos estudos publicados sobre o tema com o intuito de ampliar o conhecimento acerca do assunto e contribuir com os estudos científicos.