bluuebunny/crossref_metadata_2025 huggingface dataset:
Preparation of Poly(Ethylene Terephthalate) Track-Etched Membranes for the Separation of Water-Oil Emulsions
Authors:   Institute of Nuclear Physics of the Republic of Kazakhstan, Almaty, Kazakhstan, Yeszhanov Arman B. ,   L.N. Gumilyov Eurasian National University, Astana, Kazakhstan, Korolkov Ilya V. ,   Institute of Nuclear Physics of the Republic of Kazakhstan, Almaty, Kazakhstan,   L.N. Gumilyov Eurasian National University, Astana, Kazakhstan, Shakayeva Aigerim Kh. ,   Institute of Nuclear Physics of the Republic of Kazakhstan, Almaty, Kazakhstan,   L.N. Gumilyov Eurasian National University, Astana, Kazakhstan, Lissovskaya Lana I. ,   Institute of Nuclear Physics of the Republic of Kazakhstan, Almaty, Kazakhstan,   L.N. Gumilyov Eurasian National University, Astana, Kazakhstan, Zdorovets Maxim V. ,   Institute of Nuclear Physics of the Republic of Kazakhstan, Almaty, Kazakhstan,   L.N. Gumilyov Eurasian National University, Astana, Kazakhstan
Published: April 2023

Rapid industrial growth in the petrochemical, pharmaceutical, metallurgical and food industries, as well as stormwater that accumulates pollution from the roadway and the territories of motor transport enterprises, gas stations, car washes and other municipal services have led to the formation of a large amount of oily wastewater. Oil-containing wastewater is a multicomponent, multiphase water system and, as a rule, is in a state stabilized by various factors, which greatly complicates their processing. Pollution of water sources with oil-containing compounds leads to negative consequences for both living organisms and human health. Therefore, the need to treat oily wastewater is an urgent problem. In this article, poly(ethylene terephthalate) track-etched membranes (PET TeMs) with pore diameters of ~ 5.1 μm and pore density of 1∙106 pore/cm2 were modified by formation of polyelectrolyte complexes of PET TeMs surface with poly(allylamine) (PAAm) and tested for oil-water separation by using hexadecane/water (at pH=2) and chloroform/water (at pH=2) emulsions. Fourier-transform infrared (FTIR) spectroscopy, scanning electron microscope (SEM), energy dispersive X-ray (EDX) analysis, contact angle measurements were used for membrane characterization. The efficiency of oil-water separation was evaluated by flux measurements. Results showed separation performance of 267 mL/m2·s for hexadecane/water (pH=2) and 100 mL/m2·s for chloroform/water (pH=2) at vacuum pressure of 700 mbar.
MAPAS CONCEITUAIS NA AVALIAÇÃO DA APRENDIZAGEM DECORRENTE DE SEQUÊNCIAS DE ENSINO POTENCIALMENTE SIGNIFICATIVAS PARA O ENSINO DE CIÊNCIAS
Authors: Oliveira José Antônio Bezerra de , Smith Cavalcante Patrícia , Aquino Kátia Aparecida da Silva
Published: April 2023

O presente artigo versa sobre a avaliação de sequências de ensino idealizadas para o ensino de ciências que tenham potencial para desenvolver aprendizagens significativas, ou seja, que levem em consideração os conhecimentos prévios do estudante e a assimilação de novos conceitos de modo articulado, não-literal e substantivo, propiciando o surgimento de novos significados para ele. O objetivo do estudo foi avaliar a aprendizagem decorrente de sequências de ensino potencialmente significativas para o ensino de ciências via mapas conceituais. Sendo assim, os estudantes foram submetidos a algumas sequências de ensino e produziram mapas de conceitos antes e após cada abordagem da sequência. A análise comparativa dos mapas conceituais para cada abordagem constatou potencialidade das sequências de ensino aplicadas para a promoção de uma aprendizagem significativa. Além disso, percebeu-se que os mapas favoreceram a organização conceitual dos estudantes, indicando que seu uso nas aulas de ciências pode auxiliar o professor nos processos de ensino e aprendizagem de forma significativa e subsidiar novas perspectivas de avaliação do aprendizado.
A IMPLEMENTAÇÃO DE LABORATÓRIO FABLEARN NO MUNICÍPIO DE SOBRAL: UM ESTUDO DE CASO SOBRE O USO DA CULTURA MAKER NO ENSINO DE CIÊNCIAS NO ENSINO FUNDAMENTAL
Authors: De Sousa Gondim Raquel , De Morais Silva Daniela , Herbert Lima Vasconcelos Francisco , Rogério Santana José , Blikstein Paulo
Published: April 2023

O artigo investiga a implementação dos laboratórios FabLearn na Rede Municipal de Sobral. Dessa forma, o presente trabalho tem como objetivo retratar o processo de implantação destes laboratórios na educação básica da rede pública do município cearense de Sobral, assim como caracterizar a rede FabLearn e identificar seus contributos para o ensino de ciências na perspectiva da cultura maker. Contudo, cabe salientar que o estudo, do tipo descritivo ex-post-facto, se baseia em uma revisão bibliográfica e documental na qual as bases de dados utilizadas foram o Google Acadêmico, além das legislações e documentos oficiais competentes. Em uma perspectiva mais atualizada, concluímos que as práticas interdisciplinares conduzidas de maneira lúdica e mão na massa contribuem positivamente para o aprimoramento da qualidade do fazer docente e discente nos processos de ensino e aprendizagem.
Brain Tumor Diagnosis using Machine Learning: A Review
Authors: Abdulateef Sally Ali
Published: April 2023

Recently, early brain tumor diagnosis has grown in importance as a study area recently. The patient's rateof survival rises with early tumor detection for primarytreatment. Because ofthe high processing overhead caused by the enormous volume regardingimage input to processing system, processing magnetic resonance image (MRI) for the early detection of tumors presents a problem. This led to a significant delay and a decline in system effectiveness. As a result, recently, there has been an increased requirement for an improved detection system for precise representation and segmentationfor accurate and fasterprocessing. Latestliterature has suggested the creation of novel methods depending onenhanced processing and learningfor the detection of brain tumors. This essay provides a succinct overview of the MRI-related advancements. The machine learning (ML)algorithms' capacity for fine processing and learninghas shown an enhancementin the efficiency and accuracy of processing for the detection of the brain tumor in existing automation systems. Restrictions, advantages,and outlook for future regardingthe present approaches for computer-aided diagnostics (CAD)in the detection of the brain tumor are discussed, along with current advances in automation related tobrain tumor detections. In the presented study, researcherexplore the history of numerous methods that have been put forth to image brain tumors across a variety of domains.
Pehmeitä kumouksia : Uskonto, media, nykyaika
Authors: Taira Teemu
Published: April 2023

Pehmeitä kumouksia – Uskonto, media, nykyaika käsittelee uskontoa ja sen tutkimista nykyajan mediavetoisessa kulttuurissa. Teoksessa analysoidaan media- ja populaarikulttuurin uskonnollisuutta ja siihen vaikuttavia laajempia yhteiskunnallisia prosesseja sekä pohditaan, millaisia uusia menetelmällisiä ratkaisuja uskonnontutkimus voisi hyödyntää vastatakseen nykypäivän tarpeisiin. Teos hahmottaa kriittisiä kulttuurintutkimuksellisia ja uskontososiologisia lähestymistapoja yhdistellen pehmeitä kumouksia uskontotieteen tutkimusperinteisiin ja -kohteisiin. Sen mukaan uskontotiede on kiinnostunut enenevässä määrin nykypäivän mediakulttuurista, mikä vaatii uutta tieteidenvälistä ja kriittistä pohdintaa siitä, millainen asema uskonnolla on yhteiskunnassa.
The implications of changing educational and family circumstances for children's grade progression in rural Pakistan: 1997-2004
Authors: Lloyd Cynthia B. , Mete Cem , Grant Monica J.
Published: April 2023

This Population Council working paper assesses the effects of primary school characteristics, household characteristics, and recent household economic and demographic shocks on school dropout rates during the first eight grades in rural Punjab and North West Frontier Province, Pakistan. While grade retention has improved over the past six years, dropout rates for girls remain fairly high, particularly at the end of primary school (grade five). The results of this study show clearly the complementary nature of supply and demand factors in determining grade progression in rural Pakistan, particularly for girls. The results suggest that substantial improvement in the schooling environment in rural Pakistan is required if universal primary completion is to be achieved. These improvements alone, however, will not ensure success as long as households remain poor and continue to face substantial economic and demographic risks.
Analysis of cost and profit using aggregation operators on spherical fuzzy sets with confidence level
Authors: Lin Haofeng , Ullah Inam , Abbas Syed Zaheer , Shakeel Muhammad , Ali Asad
Published: April 2023

To deal with the ambiguity in real-world problems, researchers strive to obtain extensions to classical set theory. They introduced ideas like fuzzy set theory, spherical, intuitionistic, and Pythagorean fuzzy sets. In comparison to fuzzy sets, spherical fuzzy sets are more realistic at handling uncertainty. Fundamentals are classified in Spherical Fuzzy Set according to an attribute, and each feature has a variety of criteria. In this study, we have created a new extended algebraic structure called Confidence Spherical Fuzzy Aggregation Operators by applying the idea of Confidence Levels to the already-existing Spherical Fuzzy Aggregation Operators. We have created a Confidence Spherical Fuzzy Aggregation Operators-based end-product. We demonstrated various intriguing characteristics of Confidence Spherical Fuzzy Aggregation Operators, including operational laws. The study is validated by addressing the decision-making processes.
Array generating fuzzy petri nets and rectangular picture languages
Authors: Kaspar A. John , Christy D.K. Sheena , Gloria D.K. Shirley
Published: April 2023

A two dimensional language is a collection of two dimensional words, which are rectangular array of symbols made up of finite alphabets. Fuzzy Petri nets are the generalization of classical Petri nets designed to deal with imprecise and ambiguous data which usually occurs in knowledge based systems, image processing, etc. They have been widely used to represent fuzzy production rules and fuzzy rule-based reasoning. In this paper, a new model called array token fuzzy Petri net to generate two dimensional fuzzy regular languages has been introduced. Array token fuzzy Petri nets are used to deal with impreciseness and uncertainties occurring in two dimensional regular languages. Furthermore, proved that for every two dimensional fuzzy regular grammar there exists an array token fuzzy Petri net that generates the same two dimensional fuzzy regular language and also establish some closure properties of the languages generated by array token fuzzy Petri net.
How does organizational culture affect employees’ mental health during COVID-19? The mediating role of transparent communication
Authors: Sun Jianmin , Sarfraz Muddassar , Ivascu Larisa , Ozturk Ilknur
Published: April 2023

BACKGROUND: Over the years, the workplace landscape has significantly evolved, demanding an optimal psychological approach to establish an environment that values individual work and health. A firm’s culture inspires it to adopt business practices that enable its employees to live healthier lives. OBJECTIVE: The study aims to measure the mediating relationship of transparent communication between organizational culture and mental health in the Pakistani healthcare industry. The study also explores the relationship between organizational culture and mental health. METHODS: The study collected primary data via purposive sampling from the healthcare employees of Pakistan between March and May 2022. The study’s sample size consists of 509 respondents from the healthcare industry sector, and the research used Smart PLS software to measure the relationship through bootstrapping and algorithms. RESULTS: Organizational culture has a positive effect on the employee’s mental health. The study has found significant positive mediation of transparent communication and moderation of organizational trust between organizational culture and mental health. CONCLUSION: The COVID-19 pandemic has deteriorated workers’ mental health, causing considerable changes in the healthcare sector. Positive mental health at work is a critical factor that improves the working environment. As such, this study highlights the importance of mental health in the workplace setting. It extends the literature in the context of the healthcare industry, thus supporting employees’ well-being. The findings suggest a significant relationship between an organization’s culture and mental health. This study suggests the theoretical and practical implications for policymakers’ and researchers’ perspectives concerning employees and organizational culture.
PENGARUH MODEL PEMBELAJARAN BLENDED LEARNING BERBASIS LITERASI DIGITAL TERHADAP MOTIVASI DAN HASIL BELAJAR IPA KELAS V SEKOLAH DASAR
Authors: Wirdayani Andi , Kune Syarifuddin , Shaleh Sitti Fithriani
Published: April 2023

Penelitian ini merumuskan tujuan yaitu pengaruh model pembelajaran Blended Learning berbasis literasi digital secara simultan terhadap motivasi belajar dan hasil belajar IPA siswa. Desain penelitian yang digunakaan adalah Non equivalent Control Group Design dengan pengambilan sampel ditentukan dengan mengambil group yang tersedia tanpa melakukan random sampling. Penelitian ini menggunakan analisis statistic deskriptif dan inferensial. Sebagai persyaratan dilakukan uji persyaratan yaitu uji normalitas dan uji homogenitas dengan menggunakan Kolmogorov-Smirnov dan Levene’s test. Setelah itu dilakukan uji hipotesis dengan menggunakan uji Manova. Hasil penelitian motivasi belajar menunjukkan pada uji Kolmogriv-Smirnov berdasarkan Unstandardized Residual didapatkan hasil nilai Asymp. Sig. (2-tailed) sebesar 0,608 lebih besar dari 0,05 maka penelitian ini dapat disimpulkan berdistribusi normal. Uji manova multivariate hasil belajar bahwa nilai signifikan 0,00 < 0,05 maka dapat disimpulkan bahwa ada pengaruh model Blended Learning berbasis literasi digital secara simultan terhadap motivasi belajar dan hasil belajar IPA yang signifikan. Dengan demikian dapat disimpulkan bahwa penggunaan model pembelajaran blended learing berbasis literasi digital berpengaruh terhadap motivasi dan hasil belajar IPA siswa group V UPT SPF SD Negeri Mangkura 1 Makassar
ANALISIS LATIHAN MENEMBAK BOLA KEARAH GAWANG DENGAN MENGGUNAKAN PUNGGUNG KAKI PADA PERMAINAN SEPAK BOLA PADA CLUB LAPPA UNITED
Authors: Mappaompo M Adam , Juhanis Juhanis , Hamka Hamka , Usman Arifuddin , Salahuddin Muhammad
Published: April 2023

The problem in this research is that the Lappa United Sinjai Club in shooting at the goal is less accurate in football games . This research is an experimental research which aims to determine the effect of shooting the ball towards the goal using the back of the foot in the Lappa United Sinjai club soccer game. The population in this study were all 30 Lappa United Sinjai players, while the research sample consisted of 30 players. with sampling using total sampling. The ball shooting test is used as a data collection method. By using computer resources and the SPSS program version 21.00, descriptive statistics and inference t-test were the data analysis techniques performed. Based on the analysis of the data and the findings of this study, it can be said that training with the instep has a major impact on increasing the practice of shooting the ball towards the goal in soccer games at Club Lappa United Sinjai
Strategi Pengembangan Daya Tarik Wisata Science Center sebagai Wisata Edukasi di Kabupaten Bandung
Authors: Joseph First Son , Edison Emron , Kartika Titing
Published: April 2023

The purpose of this research is to determine the tourism attraction and development strategy in the science center of Bandung Regency. This research was conducted using a qualitative descriptive approach and SWOT analysis. Data collection was carried out through observation, interviews, and documentation. The results of the study showed that the tourism attractions in the science center were quite diverse, ranging from photo spots to interactive exhibits. However, additional tourism attractions need to be added to attract more tourists. Regarding the development strategy of tourism attractions in the science center, it is necessary to observe the environment (internal and external factors) and develop strategies through the SWOT matrix to produce alternative strategies translated into short-term goals, such as: Intensive promotion, Collaborating with other institutions, Promoting the existing educational and cultural attractions, Adding new attractions, Preparing or training tour guides who understand the exhibits, Adding several new spots of attraction, Considering natural factors for tourists' safety, Providing professional guides, medium-term goals such as providing various souvenirs, and long-term goals.
Gerenciamento de projetos de tecnologia da informação na gestão pública
Authors: Oliveira Sara Stefanie de , Silva Francisco Tasso Moreira da , Viana Lemuel Andrade
Published: April 2023

No ambiente da administração pública, investir nos serviços governamentais prestados não envolve apenas a contratação de funcionários e a realização de investimentos em Tecnologia da Informação – TI. Além dessas duas iniciativas, é necessário priorizar o planejamento, a fim de atingir os resultados esperados. Segundo Rezende (2004), o planejamento estratégico dos serviços públicos e do Sistema de Tecnologia da Informação, quando utilizado como ferramenta de gestão, é importante para que ambos tenham um desempenho bem-sucedido. Nesse contexto, o presente capítulo tem como objetivo relatar, brevemente, o planejamento e gerenciamentos na gestão de projetos de TI na área pública, evidenciando as principais ações realizadas de acordo com as necessidades e demandas da gestão, relacionando-as à ausência de indicadores de desempenho, que impactam o desenvolvimento de projetos de gestão na administração pública. Ademais, procura-se identificar respostas para as seguintes perguntas: de que forma o planejamento e os projetos de T.I. auxiliam para que a gestão pública municipal ofereça serviços de melhor qualidade? Como as tecnologias, uso de ferramentas, aplicação de sistemas, guias de melhores práticas, podem vir a contribuir de maneira efetiva e específica para o crescimento da gestão pública? Desta forma, realizou-se este estudo, visando contribuir, de alguma maneira, para o aprimoramento e compreensão das estratégias adequadas a serem aplicadas tanto no ambiente interno, quanto externo das organizações públicas municipais, para a correção e/ou soluções dos problemas existentes na área de T.I. da administração pública.
Rota da ciência: o despertar da curiosidade e inspiração de futuros cientistas
Authors: Silva Izael Oliveira , Valença Charles Anderson Carmo , Cruz Andressa Vitória de Souza , Ferreira Evenly Dhennyff , Santos Diogo Tiago dos , Lima Ianês Vieira de
Published: April 2023

A realização de práticas de laboratório na educação básica é uma ferramenta fundamental para a aprendizagem e compreensão de conceitos científicos. Essas atividades permitem que os estudantes experimentem e manipulem materiais concretos, facilitando a compreensão de conceitos abstratos. Além disso, as práticas de laboratório também ajudam a desenvolver habilidades importantes, como a resolução de problemas, a observação atenta, a comunicação e a colaboração (SOUSA, 2019). As práticas de laboratório também conseguem motivar e envolver os estudantes em sua aprendizagem, especialmente aqueles que têm uma abordagem mais prática. Ao experimentar e investigar de forma autônoma, os estudantes são estimulados a perguntar, pensar e conectar conceitos, aumentando sua compreensão e retenção de informações (CUNHA; ALMEIDA, 2018). As práticas de laboratório são uma parte crucial da educação básica, pois ajudam a desenvolver habilidades importantes, aumentar a compreensão e motivação dos estudantes. É importante que essas atividades sejam incorporadas de forma regular e significativa no currículo escolar O presente trabalho teve como objetivo desenvolver habilidades e a compreensão dos conceitos científicos em discentes da educação básica, incluindo aqueles com deficiência, por meio de experimentação prática, promovendo a inclusão, equidade, igualdade de oportunidades e preparação para futuras carreiras em ciência e tecnologia.
Connection of Kryvbas tectonics with natural and technogenic seismicity
Authors: Pihulevskyi P. H , Kendzera O. V , Babii K. V , Anisimova L. B , Kyryliuk O. S
Published: April 2023

Purpose. Studying the tectonic features of the structure of the earth’s crust of Kryvyi Rih-Kremenchuk suture zone to clarify the nature of the origin of seismic events in the Kryvbas. Methodology. To analyze and generalize the data on the Kryvbas seismicity with reference to large-scale geological and tectonic maps of exploration work. To study its tectonic structure based on geological, geophysical studies and drilling of Kryvyi Rih superdeep well. Findings. In the period 2011–2021, about 1,200 seismic events were recorded on the territory of Kryvbas, the majority of which had a minor magnitude  2.0. Among them there were identified 13 powerful industrial explosions from mb = 2.7–3.5 and 20 earthquakes of tectonic origin with mb = 2.1–4.5. Powerful explosions in mines predominantly induce earthquakes. In recent years, local earthquakes began to occur in tectonic fault zones outside the ore mining area, which indicates a change in the elastic-deformation state of the geological environment. The analysis of the attributes of local earthquakes and their locations suggests that Kryvyi Rih tectonic system and the entire eastern flank of the earth’s crust of the West Inhulets-Kryvyi Rih-Kremenchuk suture zone are geodynamically active structures, where the processes of thrust and shear tectonics are also observed on a recent geological time scale. Originality. A detailed analysis of the earthquakes shows that some of them occur at significant depths in the zones of tectonic faults outside of Kryvbas. At the same time, faults in separate directions are activated, where brittle deformations and viscous-plastic formations are manifested in the past geological time. The location of local earthquakes made it possible to single out two sections and five linear zones of seismic activity in the region. Practical value. Based on the results from this research it is possible to create an applied model of the tectonic section of the earth’s crust to solve the problems of evolution and geodynamics of the lithosphere of the Ukrainian shield, mountain geology and to optimize mining. The identified faults of active inherited development are important in determining the development paths for quarries and mines in Kryvbas.
The influence of the impeller design features on the combined operating process of the torque-flow pump
Authors: Puzik R. V , Kondus V. Y , Pavlenko I. V , Antonenko S. S
Published: April 2023

Purpose. Evaluation of the effect of changing the width of the impeller blades on the characteristics of a torque-flow pump. Searching for the optimal blade extension into the free chamber of the pump. A torque-flow pump of the “Turo” type SVN 500/32 was chosen as the subject of the research work. Methodology. A number of numerical experiments were conducted to determine the flow structure in the flowing part of a torque-flow pump. The width of the impeller blade was chosen as a variable. Numerical experiments were carried out using the ANSYS CFX software package. The integral parameters of the researched pump were determined in order to build the integral characteristics. Findings. The structure of the general flow and toroidal vortex was studied and analyzed in the torque-flow pump. A flow model was built in a torque-flow pumps with basic and modernized design. A relationship between the parameters of the pump and the change in the impeller blade width was found. The width of the impeller blade was changed in the range from min = -20 to max = +100 mm. Originality. The paper researched the effect of additional hydraulic losses caused by the mismatch between the center of the toroidal vortex and the edges of the impeller blades on the integral characteristics of the torque-flow pump. Practical value. A significant increase in the operating parameters of the “Turo” type torque-flow pump was achieved with the help of modernization of the impeller design. This allows expanding the range of the pump’s operation. At the same time, it is not required to replace such expensive elements as the pump casing.
Peculiarities of evaluating the results of implementation of regional development programs in Ukraine
Authors: Radzihovska L. M , Hulivata I. O , Husak L. P , Nikolina I. I , Ivashchuk O. V
Published: April 2023

Purpose. To systematize current problems in the field of using modern methods for evaluating the effectiveness of regional development programs in Ukraine and to substantiate the scientific foundations of program evaluation methodologies in accordance with modern principles of program-target planning. Methodology. In the process of work, generally accepted methods of scientific economic research were used, namely, systematic and comparative analysis of scientific literature, practices of development and implementation of spatial development programs in Ukraine and abroad, generalization, methods of logical abstraction and generation of conclusions. Findings. As a result of the conducted research, a problem is established of the lack of a regional development program evaluation system in Ukraine, which reduces the effectiveness of the creation and implementation of such programs. The research lays out the foundations of a scientifically based methodology for monitoring and evaluating regional development programs, which has been tested in economically developed countries and requires further scientific elaboration and introduction into the practice of state regulation of post-war reconstruction and socio-economic development of the regions of Ukraine. Originality. The scientific and practical prerequisites and the current state of the problem of forming a modern system for assessing the effectiveness of regional development programs in Ukraine are revealed. The concept of the theory and methodology of forming a modern evaluation mechanism of post-war reconstruction and development programs of Ukraine’s regions is put forward, theoretically justified and confirmed by the practice of regional management in economically developed countries. Practical value. The introduction of the proposed methodology for the development and implementation of regional development programs will ensure compliance of the practice of regional management in Ukraine with EU standards, which will contribute to European integration processes; will increase the capabilities of state authorities and local governments to attract funds for post-war reconstruction programs and further development of Ukraine’s regions; will ensure transparency of the use of funds in the process of program implementation and reduce the level of corruption risks; will increase the efficiency of program implementation in general.
Caracterización de brote, Covid-19 en Buenaventura, semana epidemiológica 22 de 2020
Authors: Soto Cortes Karen A. , Pinilla Farias Irene A. , Hurtado Zapata Juan S. , Quijada Bonilla Hernán
Published: April 2023

Antecedentes: El 26 de marzo se notificó el primer caso de COVID-19 en el distrito de Buenaventura. Al 26 de mayo se habían diagnosticado un total de 282 casos confirmados con una tasa de incidencia de 90,4 por 100 000 y una letalidad de 6,7 %; siendo el doble nacional. El objetivo fue caracterizar el brote de COVID-19 y describir medidas de mitigación y control. Materiales y métodos: Estudio de brote de COVID-19. Se incluyeron todos los casos positivos por laboratorio diagnosticados entre 26 de marzo y el 3 de junio de 2020. Se realiza búsqueda activa institucional y comunitaria. Se calcularon medidas de tendencia central y dispersión para variables cuantitativas y frecuencias absolutas, relativas y proporciones a variables cualitativas. Resultados: Se confirmaron un total de 575 casos positivos para SARS-CoV-2 al 3 de junio de 2020. El 66,2 % (375) eran hombres, la mediana de edad fue 46,5 años (RIC 26,7 – 66,2). El 2,1 % (10) de los casos activos estaba ubicados en UCI, 12,1 % (58) hospitalizados. Letalidad del 6,2 %, las comorbilidades más frecuentes en los fallecidos fueron hipertensión arterial (42 %), diabetes mellitus (36 %), insuficiencia renal (22,2 %) y obesidad (13,9 %). Conclusiones: Se confirma brote de COVID-19. Una frecuencia alta en hombres, tasa de letalidad elevada en pacientes con edad avanzada y comorbilidades principalmente metabólicas y pulmonares. Se requiere continuar con acciones de prevención, control y educación para disminuir la transmisión en la comunidad.
Investigación de brote por COVID-19 en un Centro de Protección de Personas Mayores, Leticia–Amazonas, mayo de 2020
Authors: Sanabria Castellanos Cindy Marleyi , Díaz Moreno Jorge Luis , Quijada Bonilla Hernán
Published: April 2023

Antecedentes: en Leticia, Amazonas, en un Centro de Protección se presentó un brote por COVID-19. El primer resultado confirmado correspondió a una persona mayor con síntomas respiratorios. Objetivo: caracterizar las variables sociodemográficas y epidemiológicas de la población confirmada por COVID-19 en el centro de protección de personas mayores en Leticia, Amazonas en mayo de 2020. Materiales y métodos: se realizó un estudio de brote con diseño descriptivo transversal, en el cual se recolectó información de casos confirmados y probables por COVID-19 en personas de 60 años y más y funcionarios en un Centro de Protección en Leticia, Amazonas. Resultados: el centro de protección presentó 33 beneficiarios, con media de edad de 75,6 años. El 96,8 % (30) de los beneficiarios fue mayor de 60 años, el 70,5 % (12/17) del total de casos confirmados en población beneficiaria presentó síntomas; se identificó una razón de prevalencia 2,25 (IC 95 %: 1,02–4,97). La tasa de ataque en beneficiarios fue 51,6 % y en funcionarios de 48,4 %. Conclusión: las personas mayores alojadas en centros de protección presentan una alta tasa de contagios y muertes asociada a la presencia de comorbilidades y a la inapropiada implementación de protocolos de bioseguridad y cuidado.
YEREL SİYASET BAĞLAMINDA CUMHURİYET HALK PARTİSİ (CHP) MERSİN ÜYE PROFİLİ ÜZERİNE SOSYO-EKONOMİK ANALİZ
Authors: ATÇEKEN Kandemir
Published: April 2023

Türkiye’de siyasi partiler hala en önemli siyasal katılım araçlarından birisidir. Siyasi partilerin üye profili; parti karakteristiği ve partinin siyasal katılım yapısına dair pek çok bilgiyi içermekte ve çeşitli analizler yapılmasına olanak sağlamaktadır. Yalnız siyasi partilerin farklı seviyelerindeki üye profilleri üzerine yapılan sınırlı sayıda çalışma bulunmaktadır. Çalışma bu noktada, Mersin CHP üye profili ve partinin çeşitli seviyelerinde siyaset yapma fırsatı elde etmiş üyelerin profilini, Sosyo-Ekonomik Statü (SES) modelinden faydalanarak analiz etmektedir. Çalışmada, 2019 yerel seçimleri ile uyumlu 2017 ve 2018 yıllarına ait Mersin CHP üye bilgilerini içeren iki veri seti ve bu veri setlerinin birleştirilmesiyle elde edilen 37.172 kişinin üye bilgileri incelenmiştir. Yine, çalışmayı desteklemesi amacıyla oluşturulan, Mersin CHP’ye ait 2002-2018 yılları arası milletvekilleri, 2004-2018 yılları arası belediye başkanları, 2014 yılı meclis üyeleri ve 2019 yılı yerel seçimlerinde aday adayı olan üyelere ilişkin veri setleri de analize dâhil edilmiştir. Buna göre, SES modelinin genel CHP üye profilinden çok, siyasi kariyer basamaklarında yükselme şansı elde eden (milletvekili, belediye başkanı vb.) bireylerin siyasal katılım profilini açıklamada daha anlamlı olduğu görülmüştür.
POLYNOMIAL MODELS FOR PREDICTING TIME LIMITS FOR COMPACTION AFTER MIXING OPERATION OF LATERITIC SOIL REINFORCED USING CEMENT OR LIME
Authors: Okonkwo Ugochukwu Nnatuanya , Ekeoma Emmanuel Chukwudi , Eleke Linus Owo
Published: April 2023

The demand for natural aggregates has increased in recent years because of diverse environmental interests. Consequently, its cost has soared astronomically and the utilization of lateritic soil for low-cost roads has been an attractive option. In most cases during road construction, unprecedented conditions may lead to delays in the compaction of the treated soil after the mixing operation and placing had taken place. Thus, this study developed polynomial models for predicting time limits for compaction after mixing operation within 0-180 minutes at 30 minutes intervals for lateritic soil reinforced with cement and lime. The percentage contents by weight of the dry soil for cement or quick lime mixed with the soil were 2, 4, 6, 8 and 10%. Consistency indices tests and particle size analysis were carried out on the untreated lateritic soil for characterization. The tests conducted on the lateritic soil prepared with cement and quick lime were compaction test (Standard Proctor), California Bearing Ratio (CBR) and unconfined compressive strength (UCS) of 7 days curing. The AASHTO soil classification system and Unified Soil Classification system rated the lateritic soil to be A-6(13) and clayey soil (CL), respectively. Ordinarily, the lateritic soil was found to be a poor construction soil and therefore requires treatment to improve its strength in order to make it useful for pavement purposes. At the increase in time limits for compaction after mixing, there were reductions in compaction and strength characteristics of the lateritic soils that were prepared with cement or lime. The polynomial models developed were a good fit for predicting time limits for compaction after mixing using cement/lime contents, compaction and strength characteristics of the strengthened soil. The polynomial models gave coefficients of correlation and determination of 0.988 and 0.976, respectively, when the soil was prepared with cement whereas, in the case of lime-prepared soil, the values were 0.966 and 0.933, respectively. The cement/lime contents, optimum moisture content (OMC), CBR and UCS (7 days curing) were entirely statistically significant in predicting time limits for compaction after mixing at a 95% confidence level.
EFFECT OF ADDITION OF CaO ON COMPRESSIVE STRENGTH OF HIGH-VOLUME FLY ASH CONCRETE
Authors: Mimi Mst. Mahbuba , Shakil Al-Mamun-Or-Roshid , Rashed Md. Rashedul Haque , Hasan Md. Rafi
Published: April 2023

When released into the environment as solid waste, the by-product of coal called fly ash (FA) produced by coal-based electric power plants is detrimental. A further 8% to 10% of the worldwide anthropogenic emissions are produced by cement manufacturers. These issues may be resolved with high-volume fly ash (HVFA) concrete. HVFA concrete technology refers to employing fly ash instead of cement in the concrete mix to reduce the manufacturing of cement. But when the amount of fly ash in the concrete mix increases, the concrete’s compressive strength gradually decreases. The objective of this research is to determine the mechanical properties such as the compressive strength of HVFA concrete and compare it to the strength of the control concrete by adding Calcium Oxide (CaO) as an activator. Besides this, this research has another objective to reduce the use of cement in construction by replacing it with fly ash and making an environmentally friendly form of emission of CO2 while producing cement for the cement industry. In this research, different percentages of FA such as 20, 40, 50, 60, 70, and 80 percent are adopted replacing cement in concrete mixes with and without CaO. For this, cylindrical molds with dimensions of 100 mm × 200 mm were used for preparing concrete specimens. For each percentage of HVFA concrete mixtures, 3 (three) molds were cast without the activator and the same with the activator (2% of the binding material). A total of 117 concrete specimens were cast for the compressive strength test. These molds were cured using the water-curing technique. For determining mechanical properties, the compressive strength tests after 7, 28 and 56 days were conducted. Comparisons were made between the compressive strengths of HVFA concrete with and without the activator. These outcomes were contrasted with the compressive strength of the molds of conventional concrete. The early results for the compressive strength of HVFA concrete are extremely poor. The HVFA concrete’s 28-day compressive strength test results demonstrate a much higher compressive strength than the 7-day strength. However, the HVFA concret’s 56-day compressive strength test results were more satisfactory. According to this research, long-term water curing effectively boosts the compressive strength of HVFA concrete. Additionally, the use of CaO as an activator in HVFA concrete results in a minimum of 2 MPa higher compressive strength compared to HVFA concrete without the use of an activator. This result was therefore satisfactory for concrete with the activator content for up to 60% HVFA.
Organic metal matrix Mil-88a nano-enzyme for joint repair in the osteoarthritis mouse model
Authors: Hu Hao , Huang Xu , Dai Yankun , Zhu Kairun , Ye Xuwen , Meng Shengdong , Zhang Qing , Xie Xueguan
Published: April 2023

Introduction: In this paper we tried to conduct a novel nanomaterial strategy to overcome osteoarthritis (OA) in a mouse model.

Methods: In this regard, after synthesizing the Mil-88a nanozyme, as a certain Fe-MOF, its toxic effects were detected by CCK-8 method and live-dead staining. The OA model of mouse was constructed, and paraffin sections of joints were taken for histological evaluation. In addition, immunofluorescence and immunohistochemistry were used to identify the OA progression and OARSI was used to evaluate the OA grades. We observed that Mil-88a could be easily synthesized and has high biocompatibility.

Results: We observed that Mil-88a could significantly promote the expression of OA anabolism-related genes such as Col2 and also significantly inhibit the expression of OA catabolism-related genes MMP13. Besides, we observed better OARSI score in animals treated with Mil-88a nano-enzyme loading on organic metal matrix.

Discussion: Overall, Mil-88a nano-enzyme could be used as a novel strategy to treat OA.
How forests survive alongside flammable open ecosystems: conservation implications for Africa
Authors: Cardoso Anabelle Williamson , Beckett Heath , Bond William John
Published: April 2023

Mosaics of closed, fire-sensitive forests and open flammable ecosystems are common across Africa and other parts of the world. The open ecosystems have long been interpreted as products of deforestation, but diverse lines of evidence point to their origins millions of years before humans. There is widespread concern over the survival of fire-sensitive forest in a flammable matrix, leading to diverse measures, including fire suppression, to protect forests. But if both systems are ancient, how did fire-sensitive forests survive the regular fires in the flammable open ecosystems? Here we discuss recent research on this topic, with a focus on Africa, including the stability of these mosaics through time and the factors accounting for this. These include local topography, variation in grass flammability, the presence of fire-tolerant forest margin tree species, and fauna that create firebreaks along the forest edge. We go on to discuss the conditions under which mosaics are less stable, for example during extreme fires, and consider the uncertain future of mosaicked landscapes under climate change. Finally, we suggest a set of guidelines for consideration by conservation managers concerned about fire damage to forest patches.
Rheumatoid arthritis and coronary atherosclerosis: a two-sample Mendelian randomization study
Authors: Nie Qiong , Luo Qiang , Yan Wei , Zhang Tongtong , Wang Han , Wu Jing
Published: April 2023

Objectives

The relationship between rheumatoid arthritis (RA) and coronary atherosclerosis is widely concerned, but observational studies have not clarified causality. We performed two-sample Mendelian randomization (MR) study to assess the causal association between RA and coronary atherosclerosis.

Methods

we mainly conducted MR analysis using the inverse variance weighted (IVW) approach. Weighted median, MR-Egger regression and maximum likelihood were conducted as sensitivity analyses for supplementary analysis. Multivariate MR also were performed to validate the results of two-sample MR. Furthermore, we performed the MR-Egger intercept, MR-PRESSO, Cochran's Q test, and “Leave-one-out” to assess the levels of pleiotropy and heterogeneity.

Results

IVW result showed a positive link between genetic predisposition to RA and increased relative risk of coronary atherosclerosis (OR: 1.0021, 95%CI 1.0011-1.0031, P < 0.05). The result was confirmed by the weighted median method (OR: 1.0028, 95%CI 1.0014-1.0042, P < 0.05), MR-Egger regression (OR: 1.0031, 95%CI 1.0012-1.0049, P < 0.05) and maximum likelihood (OR: 1.0021, 95%CI 1.0011-1.0030, P < 0.05). Multivariate MR also reached a consistent conclusion. In addition, MR-Egger intercept (P = 0.20) and MR-PRESSO (P = 0.06) did not provide evidence of horizontal pleiotropy. Meanwhile, the results of Cochran's Q test (P = 0.05) and “Leave-one-out” failed to detect significant heterogeneity.

Conclusion

The result of the two-sample MR analysis found genetic evidence to support the positive causal association between RA and coronary atherosclerosis, suggesting that active intervention for RA may reduce the incidence of coronary atherosclerosis.
Response to primary chemoradiotherapy of locally advanced oropharyngeal carcinoma is determined by the degree of cytotoxic T cell infiltration within tumor cell aggregates
Authors: Haist Maximilian , Kaufmann Justus , Kur Ivan-Maximiliano , Zimmer Stefanie , Grabbe Stephan , Schmidberger Heinz , Weigert Andreas , Mayer Arnulf
Published: April 2023

Background

Effective anti-tumor immune responses are mediated by T cells and require organized, spatially coordinated interactions within the tumor microenvironment (TME). Understanding coordinated T-cell-behavior and deciphering mechanisms of radiotherapy resistance mediated by tumor stem cells will advance risk stratification of oropharyngeal cancer (OPSCC) patients treated with primary chemoradiotherapy (RCTx).

Methods

To determine the role of CD8 T cells (CTL) and tumor stem cells for response to RCTx, we employed multiplex immunofluorescence stains on pre-treatment biopsy specimens from 86 advanced OPSCC patients and correlated these quantitative data with clinical parameters. Multiplex stains were analyzed at the single-cell level using QuPath and spatial coordination of immune cells within the TME was explored using the R-package Spatstat.

Results

Our observations demonstrate that a strong CTL-infiltration into the epithelial tumor compartment (HR for overall survival, OS: 0.35; p<0.001) and the expression of PD-L1 on CTL (HR: 0.36; p<0.001) were both associated with a significantly better response and survival upon RCTx. As expected, p16 expression was a strong predictor of improved OS (HR: 0.38; p=0.002) and correlated with overall CTL infiltration (r: 0.358, p<0.001). By contrast, tumor cell proliferative activity, expression of the tumor stem cell marker CD271 and overall CTL infiltration, regardless of the affected compartment, were not associated with response or survival.

Conclusion

In this study, we could demonstrate the clinical relevance of the spatial organization and the phenotype of CD8 T cells within the TME. In particular, we found that the infiltration of CD8 T cells specifically into the tumor cell compartment was an independent predictive marker for response to chemoradiotherapy, which was strongly associated with p16 expression. Meanwhile, tumor cell proliferation and the expression of stem cell markers showed no independent prognostic effect for patients with primary RCTx and thus requires further study.
Interplay among differential exposure to Mycobacterium leprae and TLR4 polymorphism impacts the immune response in household contacts of leprosy patients
Authors: Cunha Eloisa Helena Medeiros , Marçal Pedro Henrique Ferreira , Gama Rafael Silva , de Oliveira Lorena Bruna Pereira , Pinheiro Roberta Olmo , Sarno Euzenir Nunes , Brito-de-Sousa Joaquim Pedro , de Souza Márcio Luís Moreira , Fairley Jessica Kathleen , Valente Thaisa Netto Souza , Velloso-Rodrigues Cibele , Martins-Filho Olindo Assis , de Oliveira Dirce Ribeiro , Fraga Lucia Alves de Oliveira
Published: April 2023

Introduction

The aim of the present study was to investigate the association between the single nucleotide polymorphism (SNP) rs1927914 A/G in TLR4 gene and the immunological profile of household contacts (HHC) of leprosy patients. Leprosy classification is usually complex and requires the assessment of several clinical and laboratorial features.

Methods

Herein, we have applied distinct models of descriptive analysis to explore qualitative/quantitative changes in chemokine and cytokine production in HHC further categorized according to operational classification [HHC(PB) and HHC(MB)] and according to TLR4SNP.

Results and discussion

Our results showed that M. leprae stimuli induced an outstanding production of chemokines (CXCL8;CCL2; CXCL9; CXCL10) by HHC(PB), while increase levels of pro-inflammatory cytokines (IL-6; TNF; IFN-γ; IL-17) were observed for HHC(MB). Moreover, the analysis of chemokine and cytokine signatures demonstrated that A allele was associated with a prominent soluble mediator secretion (CXCL8; CXCL9; IL-6; TNF; IFN-γ). Data analysis according to TLR4 SNP genotypes further demonstrated that AA and AG were associated with a more prominent secretion of soluble mediators as compared to GG, supporting the clustering of AA and AG genotypes into dominant genetic model. CXCL8, IL-6, TNF and IL-17 displayed distinct profiles in HHC(PB) vs HHC(MB) or AA+AG vs GG genotype. In general, chemokine/cytokine networks analysis showed an overall profile of AA+GA-selective (CXCL9–CXCL10) and GG-selective (CXCL10–IL-6) axis regardless of the operational classification. However, mirrored inverted CCL2–IL-10 axis and a (IFN-γ–IL-2)-selective axis were identified in HHC(MB). CXCL8 presented outstanding performance to classify AA+AG from GG genotypes and HHC(PB) from HHC(MB). TNF and IL-17 presented elevated accuracy to classify AA+AG from GG genotypes and HHC(PB) (low levels) from HHC(MB) (high levels), respectively. Our results highlighted that both factors: i) differential exposure to M. leprae and ii) TLR4 rs1927914 genetic background impact the immune response of HHC. Our main results reinforce the relevance of integrated studies of immunological and genetic biomarkers that may have implications to improve the classification and monitoring of HHC in future studies.