bluuebunny/crossref_metadata_2025 huggingface dataset:
Down syndrome regression disorder, a case series: Clinical characterization and therapeutic approaches
Authors: Bonne Sidney , Iftimovici Anton , Mircher Clotilde , Conte Martine , Louveau Cécile , Legrand Adrien , Danset-Alexandre Charlotte , Cannarsa Costanza , Debril Alexis , Consoli Angèle , Krebs Marie-Odile , Ellul Pierre , Chaumette Boris
Published: February 2023

Down syndrome (DS) is one of the most frequent genetic disorders and represents the first cause of intellectual disability of genetic origin. While the majority of patients with DS follow a harmonious evolution, an unusual neurodevelopmental regression may occur, distinct from that described in the context of autism spectrum disorders, called down syndrome regression disorder (DSRD). Based on four patients, two males and two females, with age range between 20 and 24, treated at the Reference Center for Rare Psychiatric Disorders of the GHU Paris Psychiatry and Neurosciences [Pôle hospitalo-universitaire d’Évaluation Prévention et Innovation Thérapeutique (PEPIT)], we describe this syndrome, discuss its etiologies and propose therapeutic strategies. DSRD often occurs in late adolescence. There is a sudden onset of language disorders, loss of autonomy and daily living skills, as well as behavioral symptoms such as depression, psychosis, or catatonia. These symptoms are non-specific and lead to an overlap with other diagnostic categories, thus complicating diagnosis. The etiologies of the syndrome are not clearly identified but certain predispositions of patients with trisomy 21 have suggested an underlying immune-mediated mechanism. Symptomatic therapeutic approaches (serotonergic antidepressants, atypical antipsychotics, benzodiazepines) were not effective, and generally associated with poor tolerance. Etiological treatments, including anti-inflammatory drugs and corticosteroids, led to partial or good recovery in the four cases. Early recognition of regressive symptoms and rapid implementation of adapted treatments are required to improve the quality of life of patients and their families.
Sociodemographic and lifestyle factors and the risk of metabolic syndrome in taxi drivers: A focus on street food
Authors: Sekgala Machoene Derrick , Opperman Maretha , Mpahleni Buhle , Mchiza Zandile June-Rose
Published: February 2023

Background

In South Africa, similar to other populous countries, the taxi industry is an important form of transportation that contributes to the country's development. As a result, minibus taxi driving is an occupation characterized by strenuous activities such as long hours of driving, limited rest, and challenges related to securing passengers, among several others. Consequently, to combat stress, some commercial drivers resort to smoking, overeating unhealthy food sold at transportation interchange areas (i.e., taxi ranks), and participating in sedentary behaviors. Most of these activities are risk factors for metabolic syndrome (MetS).

Aim

Therefore, this study aimed to investigate the sociodemographic and lifestyle factors that predispose South African taxi drivers who work in the Cape Town Metropole area to the risk of developing MetS.

Methods

This cross-sectional study used a convenient sampling method that included 185 male minibus taxi drivers aged 20 years or above. The participants were interviewed using a validated questionnaire to gather information regarding their sociodemographic characteristics and lifestyle practices. They also underwent physical and metabolic assessments, and the International Diabetes Federation (IDF) criteria were used to diagnose people with MetS.

Results

Overall, the mean age and driving experience of the taxi drivers were 40.0 years (SD: 10.7) and 9.1 years (SD: 7.4), respectively, with those with MetS being significantly older and having more driving experience than those without. Older participants were 3 and 2.9 times more likely to be diagnosed with MetS than the younger participants. Most taxi drivers (70%) met the IDF diagnostic criteria for MetS. Smokers, those who spent more than 100 ZAR (USD 5.9) and those who spent less than 1.4 MET-minutes per week on physical activity were 1.96, 2.0, and 13.6 times more likely to suffer from MetS that those who were nonsmokers, those who spent less than 100 ZAR and those who spent <1.4 MET-minutes per week on physical activity. Consumption of alcohol and sugar-sweetened beverages (SSBs), as well as takeaway and fried foods, snacks, and sold by the SF vendors, increased the likelihood of developing MetS, abnormal HDL-C, TG, and hypertension, while avoiding takeaway and fried foods decreased this likelihood. Taxi drivers who also avoided consuming fresh fruits had abnormal HDL-C.

Conclusion

These findings have significant public health implications, highlighting the need for South African policymakers to adopt a system-level approach to promote lifestyle changes among taxi drivers within the taxi industry. This can help reduce the health risks faced by these drivers and improve their overall health profile.
Clinical factors influencing long-term survival in a real-life cohort of early stage non-small-cell lung cancer patients in Spain
Authors: Torrente Maria , Sousa Pedro A. , Guerreiro Gracinda R. , Franco Fabio , Hernández Roberto , Parejo Consuelo , Sousa Alexandre , Campo-Cañaveral José Luis , Pimentão João , Provencio Mariano
Published: February 2023

Background

Current prognosis in oncology is reduced to the tumour stage and performance status, leaving out many other factors that may impact the patient´s management. Prognostic stratification of early stage non-small-cell lung cancer (NSCLC) patients with poor prognosis after surgery is of considerable clinical relevance. The objective of this study was to identify clinical factors associated with long-term overall survival in a real-life cohort of patients with stage I-II NSCLC and develop a prognostic model that identifies features associated with poor prognosis and stratifies patients by risk.

Methods

This is a cohort study including 505 patients, diagnosed with stage I-II NSCLC, who underwent curative surgical procedures at a tertiary hospital in Madrid, Spain.

Results

Median OS (in months) was 63.7 (95% CI, 58.7-68.7) for the whole cohort, 62.4 in patients submitted to surgery and 65 in patients submitted to surgery and adjuvant treatment. The univariate analysis estimated that a female diagnosed with NSCLC has a 0.967 (95% CI 0.936 - 0.999) probability of survival one year after diagnosis and a 0.784 (95% CI 0.712 - 0.863) five years after diagnosis. For males, these probabilities drop to 0.904 (95% CI 0.875 - 0.934) and 0.613 (95% CI 0.566 - 0.665), respectively. Multivariable analysis shows that sex, age at diagnosis, type of treatment, ECOG-PS, and stage are statistically significant variables (p<0.10). According to the Cox regression model, age over 50, ECOG-PS 1 or 2, and stage ll are risk factors for survival (HR>1) while adjuvant chemotherapy is a good prognostic variable (HR<1). The prognostic model identified a high-risk profile defined by males over 71 years old, former smokers, treated with surgery, ECOG-PS 2.

Conclusions

The results of the present study found that, overall, adjuvant chemotherapy was associated with the best long-term OS in patients with resected NSCLC. Age, stage and ECOG-PS were also significant factors to take into account when making decisions regarding adjuvant therapy.
Safety and feasibility of robotic-assisted thoracic surgery after neoadjuvant chemoimmunotherapy in non-small cell lung cancer
Authors: Zeng Jun , Yi Bin , Chang Ruimin , Chen Yufan , Yu Zhongjie , Gao Yang
Published: February 2023

Objectives

This study aimed to evaluate the safety and feasibility of robotic-assisted thoracic surgery (RATS) after neoadjuvant chemoimmunotherapy in NSCLC.

Methods

We retrospectively collected data for NSCLC patients who received thoracic surgery after neoadjuvant chemoimmunotherapy from May 2020 to August 2022. Surgery details, pathological response, and perioperative outcome were compared between video-assisted thoracic surgery (VATS) group and RATS group. Inverse probability of treatment weighting (IPTW) was used to equal the baseline characteristics.

Results

A total of 220 patients were divided into 78 VATS patients and 142 RATS patients. There was no 90-day mortality in either group. RATS patients demonstrated better results in conversion rate to thoracotomy (VATS vs. RATS: 28.2% vs. 7.5%, P < 0.001), number of lymph node stations harvested (5.63 ± 1.75 vs. 8.09 ± 5.73, P < 0.001), number of lymph nodes harvested (13.49 ± 9.325 vs. 20.35 ± 10.322, P < 0.001), yield pathologic-N (yp-N) assessment (yp-N0, 88.5% vs. 67.6%; yp-N1, 7.6% vs. 12.6%; yp-N2, 3.8% vs. 19.7%; P < 0.001), and visual analog scale pain score after surgery (4.41 ± 0.93 vs. 3.77 ± 1.21, P=0.002). However, there were no significant differences in pathological response evaluation for neoadjuvant chemoimmunotherapy (P = 0.493) and complication rate (P = 0.803). After IPTW-adjustment, these results remained constant.

Conclusions

RATS reduced the risk of conversion to thoracotomy, provided a better yp-N stage evaluation, and improved pain score; this suggests that RATS is safe and feasible for NSCLC patients after neoadjuvant chemoimmunotherapy.
Global scientific trends in laparoscopy and gastric cancer in the 21st century: A bibliometric and visual mapping analysis
Authors: Han Hongmin , Wang Zhanwei , Zhao Xiaodan , Li Guosheng , Fu Yuan , Wang Zhongqing , Wang Hongyan
Published: February 2023

Aims

To use visual mapping and bibliometrics to analyze and summarize the valuable information on laparoscopic surgery for gastric cancer (GC) obtained in the last 20 years, so as to determine the research hotspots and trends in this field.

Methods

We screened all literature on laparoscopic surgery for GC in the Web of Science published from 2000 to 2022 and analyzed the research hotspots and trends in this field using VOSviewer.

Results

A total of 2796 reports from 61 countries and regions were selected. Japanese researchers published the most papers (n=946), followed by those from China (n=747) and South Korea (n=557). Papers from Japan also had the most citations (n=21,836). Surgical Endoscopy and Other Interventional Techniques published the most reports on laparoscopic surgery for GC (n=386) and also had the highest total number of citations (n=11,076), making this journal the most authoritative in this field. Among the institutions, researchers from Seoul National University in South Korea had the highest numbers of published papers and citations. The keywords of the articles could be divided into five categories: surgical methods for GC, short-term and long-term efficacy of laparoscopic surgery, guiding role of laparoscopy in the treatment of advanced GC, diagnosis and treatment of early gastric cancer (EGC), and lymph node dissection. Keywords such as “laparoscopic proximal gastrectomy”, “surgical outcomes”, and “esophagogastric junction” have emerged recently, and relevant studies on laparoscopic surgery for adenocarcinoma of esophagogastric junction(AEG)have gradually become a hot topic and trend.

Conclusion

This study adopted bibliometric analysis to identify the current research hotspots and research trends in the field of laparoscopic surgery for GC. Five main research hotspots of laparoscopic surgery for GC were also identified. Laparoscopic surgery for AEG may become an important research focus in the future.
Prognostic factors and models to predict pediatric sepsis mortality: A scoping review
Authors: Yuniar Irene , Hafifah Cut Nurul , Adilla Sharfina Fulki , Shadrina Arifah Nur , Darmawan Anthony Christian , Nasution Kholisah , Ranakusuma Respati W. , Safitri Eka Dian
Published: February 2023

Introduction

Several scoring systems are available to assess the severity of sepsis in pediatric patients in diverse settings worldwide. This study investigates the quality and applicability of predictive models for determining pediatric sepsis mortality, especially in acute care and limited-resource settings.

Data sources

Mortality prediction factors and models were searched in four databases using the following criteria: developed for pediatric health care, especially in acute settings, and with mortality as an outcome.

Study selection

Two or more reviewers performed the study selection to ensure no bias occurred. Any disagreements were solved by consensus or by the decision of a third reviewer.

Data extraction

The authors extracted the results and mapped the selected studies qualitatively to describe the prognostic properties of the risk factors and models proposed in the study.

Data synthesis

The final analysis included 28 mortality prediction models. Their characteristics, analysis, and performance measures were summarized. Performance was described in terms of calibration and discrimination, including assessing for risk of bias and applicability. A modified version of the PRISM-III score based on physiologic criteria (PRISM-III-APS) increased its predictive value to 0.85–0.95. The vasoactive-inotropic score at 12 h had a strong independent association with death. Albumin had an excellent predictive value when combined with other variables. Lactate, a biomarker widely measured in patients with sepsis, was highly associated with mortality. The bioimpedance phase angle was not considered applicable in our setting. Measurement using more straightforward methods, such as mid-upper arm circumference, was feasible in numerous health care facilities.

Conclusion

Leveraging prognostic models to predict mortality among pediatric patients with sepsis remains an important and well-recognized area of study. While much validation and development work remains to be done, available prognostic models could aid clinicians at the bedside of children with sepsis. Furthermore, mortality prediction models are essential and valuable tools for assessing the quality of care provided to critically ill pediatric patients.
Real pandemic world results of pharmacokinetic-tailored personalized prophylaxis of bleeds in Polish children and adolescents with severe hemophilia A
Authors: Urasiński Tomasz , Paczóska Klaudia , Badowska Wanda , Bobrowska Halina , Dakowicz Łucja , Dobaczewski Grzegorz , Latos-Grażyńska Elżbieta , Karolczyk Grażyna , Klukowska Anna , Kołtan Andrzej , Wojdalska Magdalena , Łaguna Paweł , Niedźwiedzki Maciej , Pietrys Danuta , Radoń-Proskura Julia , Radwańska Monika , Rurańska Iwona , Szczepański Tomasz , Wasiński Dariusz , Woźnica-Karczmarz Irena , Zielezińska Karolina , Królak Aleksandra , Ociepa Tomasz
Published: February 2023

Introduction

In 2020, the new nationwide protocol of prophylaxis in Polish plasma-derived FVIII (pdFVIII) previously treated patients (PTPs) with severe hemophilia A (sHA) was introduced, resulting in the necessity of switching from pdFVIII to recombinant FVIII (octocog-alpha; rFVIII). The study aimed to: (1) assess the safety of switching from pdFVIII to rFVIII, (2) assess the safety and efficacy of pharmacokinetically based (PK-based) personalized prophylaxis in severe hemophilia A.

Patients and methods

151 children and adolescents receiving prophylaxis with a standard dose (40 U/kg 3 x weekly) of pdFVIII were included in this study. Annualized bleeding rate (ABR) and annualized joint bleeding rate (AJBR) were analyzed for all patients before enrollment. Using myPKFiT application, pharmacokinetic (PK) analysis followed by the selection of the optimal model of prophylaxis was performed in all patients. Two possible models of prophylaxis (standard-dose rFVIII versus PK-based rFVIII) were discussed, with parents leaving the choice to their decision. Parents reported all episodes of bleeds. Screening for inhibitor was performed every 3 months. ABR and AJBR were prospectively analyzed again after a minimum follow-up time of 26 weeks.

Results

141/151 (93.4%) patients completed the study. 34 patients decided to continue standard prophylaxis with rFVIII (Group I), whereas 107 were switched to PK-based prophylaxis (Group II). The risk of inhibitor development could be assessed in 137/151 (90.7%) patients. Only 2/137 (1.47%) patients (both on PK-based prophylaxis) developed low-titer inhibitor with its spontaneous elimination. The retrospective analysis of bleeds during the last 12 months of standard pdFVIII prophylaxis revealed that patients who decided to continue standard prophylaxis had historically lower ABR and AJBR than those who started PK-based personalized prophylaxis. After a minimum of 26 weeks, ABR and AJBR improved significantly in both groups. There was no significant difference in ABR and AJBR between Group I and Group II during the follow-up period. However, the rate of reduction of ABR and AJBR was higher in patients on PK-based personalized prophylaxis.

Conclusion

(1) Switching from pdFVIII to rFVIII (octocog-alpha) in PTPs with sHA is safe, (2) PK-based personalized prophylaxis may decrease ABR and AJBR in children and adolescents with sHA.
Research and application of intelligent image processing technology in the auxiliary diagnosis of aortic coarctation
Authors: Yan Taocui , Qin Jinjie , Zhang Yulin , Li Qiuni , Han Baoru , Jin Xin
Published: February 2023

Objective

To explore the application of the proposed intelligent image processing method in the diagnosis of aortic coarctation computed tomography angiography (CTA) and to clarify its value in the diagnosis of aortic coarctation based on the diagnosis results.

Methods

Fifty-three children with coarctation of the aorta (CoA) and forty children without CoA were selected to constitute the study population. CTA was performed on all subjects. The minimum diameters of the ascending aorta, proximal arch, distal arch, isthmus, and descending aorta were measured using manual and intelligent methods, respectively. The Wilcoxon signed-rank test was used to analyze the differences between the two measurements. The surgical diagnosis results were used as the gold standard, and the diagnostic results obtained by the two measurement methods were compared with the gold standard to quantitatively evaluate the diagnostic results of CoA by the two measurement methods. The Kappa test was used to analyze the consistency of intelligence diagnosis results with the gold standard.

Results

Whether people have CoA or not, there was a significant difference (p < 0.05) in the measurements of the minimum diameter at most sites using the two methods. However, close final diagnoses were made using the intelligent method and the manual. Meanwhile, the intelligent measurement method obtained higher accuracy, specificity, and AUC (area under the curve) compared to manual measurement in diagnosing CoA based on Karl's classification (accuracy = 0.95, specificity = 0.9, and AUC = 0.94). Furthermore, the diagnostic results of the intelligence method applied to the three criteria agreed well with the gold standard (all kappa ≥ 0.8). The results of the comparative analysis showed that Karl's classification had the best diagnostic effect on CoA.

Conclusion

The proposed intelligent method based on image processing can be successfully applied to assist in the diagnosis of CoA.
Setting a stage: Inflammation during preeclampsia and postpartum
Authors: Herrock Owen , Deer Evangeline , LaMarca Babbette
Published: February 2023

Preeclampsia (PE) is a leading cause of maternal and fetal mortality worldwide. The immune system plays a critical role in normal pregnancy progression; however, inappropriate inflammatory responses have been consistently linked with PE pathophysiology. This inflammatory phenotype consists of activation of the innate immune system, adaptive immune system, and increased inflammatory mediators in circulation. Moreover, recent studies have shown that the inflammatory profile seen in PE persists into the postpartum period. This manuscript aims to highlight recent advances in research relating to inflammation in PE as well as the inflammation that persists postpartum in women after a PE pregnancy. With the advent of the COVID-19 pandemic, there has been an increase in obstetric disorders associated with COVID-19 infection during pregnancy. This manuscript also aims to shed light on the relationship between COVID-19 infection during pregnancy and the increased incidence of PE in these women.
Susceptibility of pruning wounds to grapevine trunk diseases: A quantitative analysis of literature data
Authors: Rosace Maria Chiara , Legler Sara Elisabetta , Salotti Irene , Rossi Vittorio
Published: February 2023

Introduction

Pruning wounds are the main entry points for fungi causing grapevine trunk diseases (GTDs). Several studies identified factors influencing the temporal dynamics of wound susceptibility, which include the fungal species and inoculum dose, weather conditions, grape variety, pruning date, and so forth. Here, we conducted a quantitative analysis of literature data to synthesise outcomes across studies and to identify the factors that most affect the length of pruning wound susceptibility.

Methods

We extracted data on the frequency at which the inoculated wounds showed GTD symptoms or an inoculated pathogen was reisolated following artificial inoculation at the time of pruning or in the following days. A negative exponential model was fit to these data to describe changes in wound susceptibility as a function of time since pruning, in which the rate parameter changed depending on specific factors.

Results and Discussion

The results show that wound susceptibility is high at the time of pruning, and they remain susceptible to invasion by GTD fungi for months after pruning. Infection incidence on wounds was higher for fungi associated with Botryosphaeria dieback than those associated with Eutypa dieback or Esca complex, and wound susceptibility decreased faster for Eutypa dieback than for other GTD agents. Grapevine variety and pruning season also affected the wound susceptibility period. Sauvignon Blanc remains susceptible to GTDs longer than other varieties. We also found that the time of pruning can affect infection dynamics, especially for more susceptible varieties. The results increase our understanding of GTD epidemiology and should help growers control infections.
Merging the occurrence possibility into gene co-expression network deciphers the importance of exogenous 2-oxoglutarate in improving the growth of rice seedlings under thiocyanate stress
Authors: Feng Yu-Xi , Yang Li , Lin Yu-Juan , Song Ying , Yu Xiao-Zhang
Published: February 2023

Thiocyanate (SCN−) can find its way into cultivated fields, which might hamper the harmony in carbon and nitrogen metabolism (CNM) of plants, ebbing their quality and productivity. In the current study, we investigated the role of the exogenous application of 2-oxoglutarate (2-OG) in maintaining homeostasis of CNM in rice seedlings under SCN− stress. Results showed that SCN− exposure significantly repressed the gene expression and activities of CNM-related enzymes (e.g., phosphoenolpyruvate carboxylase, NADP-dependent isocitrate dehydrogenases, and isocitrate dehydrogenases) in rice seedlings, thereby reducing their relative growth rate (RGR). Exogenous application of 2-OG effectively mitigated the toxic effects of SCN− on rice seedlings, judged by the aforementioned parameters. The co-expression network analysis showed that genes activated in CNM pathways were categorized into four modules (Modules 1–4). In order to identify the key module activated in CNM in rice seedlings exposed to SCN−, the results from real-time quantitative PCR (RT-qPCR) tests were used to calculate the possibility of the occurrence of genes grouped in four different modules. Notably, Module 3 showed the highest occurrence probability, which is mainly related to N metabolism and 2-OG synthesis. We can conclude that exogenous application of 2-OG can modify the imbalance of CNM caused by SCN− exposure through regulating N metabolism and 2-OG synthesis in rice seedlings.
Sustaining nitrogen dynamics: A critical aspect for improving salt tolerance in plants
Authors: Nazir Faroza , Mahajan Moksh , Khatoon Sayeda , Albaqami Mohammed , Ashfaque Farha , Chhillar Himanshu , Chopra Priyanka , Khan M. Iqbal R.
Published: February 2023

In the current changing environment, salt stress has become a major concern for plant growth and food production worldwide. Understanding the mechanisms of how plants function in saline environments is critical for initiating efforts to mitigate the detrimental effects of salt stress. Agricultural productivity is linked to nutrient availability, and it is expected that the judicious metabolism of mineral nutrients has a positive impact on alleviating salt-induced losses in crop plants. Nitrogen (N) is a macronutrient that contributes significantly to sustainable agriculture by maintaining productivity and plant growth in both optimal and stressful environments. Significant progress has been made in comprehending the fundamental physiological and molecular mechanisms associated with N-mediated plant responses to salt stress. This review provided an (a) overview of N-sensing, transportation, and assimilation in plants; (b) assess the salt stress-mediated regulation of N dynamics and nitrogen use- efficiency; (c) critically appraise the role of N in plants exposed to salt stress. Furthermore, the existing but less explored crosstalk between N and phytohormones has been discussed that may be utilized to gain a better understanding of plant adaptive responses to salt stress. In addition, the shade of a small beam of light on the manipulation of N dynamics through genetic engineering with an aim of developing salt-tolerant plants is also highlighted.
EADD-YOLO: An efficient and accurate disease detector for apple leaf using improved lightweight YOLOv5
Authors: Zhu Shisong , Ma Wanli , Wang Jianlong , Yang Meijuan , Wang Yongmao , Wang Chunyang
Published: February 2023

Introduction

Current detection methods for apple leaf diseases still suffer some challenges, such as the high number of parameters, low detection speed and poor detection performance for small dense spots, which limit the practical applications in agriculture. Therefore, an efficient and accurate model for apple leaf disease detection based on YOLOv5 is proposed and named EADD-YOLO.

Methods

In the EADD-YOLO, the lightweight shufflenet inverted residual module is utilized to reconstruct the backbone network, and an efficient feature learning module designed through depthwise convolution is proposed and introduced to the neck network. The aim is to reduce the number of parameters and floating point of operations (FLOPs) during feature extraction and feature fusion, thus increasing the operational efficiency of the network with less impact on detection performance. In addition, the coordinate attention module is embedded into the critical locations of the network to select the critical spot information and suppress useless information, which is to enhance the detection accuracy of diseases with various sizes from different scenes. Furthermore, the SIoU loss replaces CIoU loss as the bounding box regression loss function to improve the accuracy of prediction box localization.

Results

The experimental results indicate that the proposed method can achieve the detection performance of 95.5% on the mean average precision and a speed of 625 frames per second (FPS) on the apple leaf disease dataset (ALDD). Compared to the latest research method on the ALDD, the detection accuracy and speed of the proposed method were improved by 12.3% and 596 FPS, respectively. In addition, the parameter quantity and FLOPs of the proposed method were much less than other relevant popular algorithms.

Discussion

In summary, the proposed method not only has a satisfactory detection effect, but also has fewer parameters and high calculation efficiency compared with the existing approaches. Therefore, the proposed method provides a high-performance solution for the early diagnosis of apple leaf disease and can be applied in agricultural robots. The code repository is open-sourced at https://github.com/AWANWY/EADD-YOLO.
Volatile metabolites from new cultivars of catnip and oregano as potential antibacterial and insect repellent agents
Authors: Patel Harna K. , Gomes Erik Nunes , Wu Qingli , Patel Nrupali , Kobayashi Donald Y. , Wang Changlu , Simon James E.
Published: February 2023

Plant based natural products have been widely used as antibacterial and insect repellent agents globally. Because of growing resistance in bacterial plant pathogens and urban pests to current methods of control, combined with the long- and short-term negative impact of certain chemical controls in humans, non-target organisms, and the environment, finding alternative methods is necessary to prevent and/or mitigate losses caused by these pathogens and pests. The antibacterial and insect repellent activities of essential oils of novel cultivars of catnip (Nepeta cataria L. cv. CR9) and oregano (Origanum vulgare L. cv. Pierre) rich in the terpenes nepetalactone and carvacrol, respectively, were evaluated using the agar well diffusion assay and petri dish repellency assay. The essential oils exhibit moderate to high antibacterial activity against three plant pathogens, Pseudomonas cichorii, Pseudomonas syringae and Xanthomonas perforans of economic interest and the individual essential oils, their mixtures and carvacrol possess strong insect repellent activity against the common bed bug (Cimex lectularius L.), an urban pest of major significance to public health. In this study, the essential oils of catnip and oregano were determined to be promising candidates for further evaluation and development as antibacterial agents and plant-based insect repellents with applications in agriculture and urban pest management.
Genome-wide characterization and expression of DELLA genes in Cucurbita moschata reveal their potential roles under development and abiotic stress
Authors: Luo Weirong , Zhao Zhenxiang , Chen Hongzhi , Ao Wenhong , Lu Lin , Liu Junjun , Li Xinzheng , Sun Yongdong
Published: February 2023

DELLA gene family plays a key role in regulating plant development and responding to stress. Currently, many DELLA family members have been identified in plants, however, information on DELLA genes in pumpkin (Cucurbita moschata) is scarce. In this study, physical and chemical properties, gene structure cis-regulatory elements and expression of CmoDELLA genes were examined in pumpkin. We found that seven CmoDELLA genes were identified in pumpkin, and they were unevenly classified into five chromosomes. CmoDELLA proteins were relatively unstable and their secondary structures were mainly made up α-helix and random coil. All seven CmoDELLA proteins contained typical DELLA domain and GRAS domain, however, motif numbers between CmoDELLA proteins were unevenly distributed, implying the complex evolution and functional diversification of CmoDELLA proteins. Cis-regulatory elements analysis revealed that CmoDELLA genes might play an essential role in regulating plant growth and development, and response to stress in pumpkin. Transcriptome data in the roots, stems, leaves and fruits demonstrated that CmoDELLA2, CmoDELLA3 and CmoDELLA7 were related to the stems development, CmoDELLA1, CmoDELLA4, CmoDELLA5 and CmoDELLA6 were associated with the fruits development. Furthermore, we found that CmoDELLA1 and CmoDELLA5 were up-regulated under NaCl stress. CmoDELLA1, CmoDELLA2, CmoDELLA3, CmoDELLA5, CmoDELLA6 and CmoDELLA7 were remarkably induced under waterlogging stress. While, all of the 7 CmoDELLA genes showed significantly induced expression under cold stress. The expression patterns under abiotic stress suggested that CmoDELLA genes might mediate the stress response of pumpkin to NaCl, waterlogging and cold, however, the functions of different CmoDELLA genes varied under different stress. Overall, our study provides valuable information for further research about the potential functions and regulatory networks of CmoDELLA genes in pumpkin.
The relationship among safety leadership, risk perception, safety culture, and safety performance: Military volunteer soldiers as a case study
Authors: Wei Siao-Yun , Kuo Yen-Ku
Published: February 2023

Safety is fundamental to any organization; if not based on safety, organizational decision-making and management would be meaningless. For a country, soldiers are responsible for national security; they serve as a barrier that defends a country against external invasive forces, thus assuming great missions and responsibilities on their shoulders. To ensure soldiers fulfill their duties of protecting the country and the people, they should gain clear risk perception, which should be instilled into them during their daily combat readiness training. Only when their performances meet safety criteria can they become a strong fighting force. This study recruited military volunteer soldiers as its research participants and employed convenience sampling to distribute questionnaires. In total, this research collected 725 valid copies, of which the data were used to explore the relationship among safety leadership, risk perception, safety culture, and safety performance. To achieve this goal, this study proposed some research hypotheses based on literature review. The hypotheses were all verified via latent variable modeling and multiple hierarchical regression analysis after the reliability and validity of each construct had been tested via confirmatory factor analysis. The research results showed that the more deeply military volunteer soldiers sense safety leadership, the clearer their risk perception will be and the more helpful it would be in achieving safety performance. It is worth mentioning that risk perception can serve as a mediator while safety culture can mediate the relationship between safety leadership and safety performance. Lastly, the research proposes suggestions in the section of conclusions, which provides reference to the combat readiness training and daily tasks of soldiers.
Unconscious processing of prototype heuristics in scientific innovation problem-solving
Authors: Ling Yushi , Tan Liu , Zhang Liyi , Cao Guikang
Published: February 2023

Previously published studies on the effect of how different levels of unconsciousness (UC) and different loads of executive functions (EFs) affect insight problem solving are inconsistent. In a set of three experiments, we used scientific innovation problems (SIP) as insight metrics and distractor tasks to induce UC. Experiment 1 confirmed that, compared with conscious processing, unconscious processing is more conducive to obtaining prototype heuristics for correctly solving scientific innovation problems creatively. Furthermore, Experiment 2 found that different levels of unconscious processing, which were induced by different distractor tasks, made a different impact on high or low difficulty creative problem solving. Experiment 3 indicated that unconscious processing could improve prototype activation and the ability to use key heuristics information in prototype heuristics processing by improving working memory, inhibitory control, and shifting ability of EFs. Overall, the present results provide additional evidence for the role of consciousness levels in insight problem solving.
Social trust and the location choices of foreign firms in China–The moderating role of formal institution and cultural distance
Authors: Shen Huiyun , Yi Changjun , Yu Jie , Gou Jin
Published: February 2023

The institutional environment has a significant impact on the location of overseas investments by multinational enterprises (MNEs). However, there remain two research gaps. First, fewer studies focused on the impact of subnational regional institutions on the location choices of MNEs. Second, study on informal institutions has been more limited. This study investigates the effect of the informal institution (social trust) in the Chinese subnational region on the location choices of foreign firms and the mechanism of its role. Using the sample of foreign firms’ location choices in China from 2008 to 2020 in Orbis Global Enterprise Database, this study finds that social trust positively related to the location choices of foreign firms in subnational regions. Our results also show that this positive effect is contingent on the formal institution and the cultural distance between home and host country. When the formal institution is strong and the cultural distance between home and host country is high, social trust has a more significant positive impact on the location choices of foreign firms in subnational regions. Besides, the results show that cost advantage, information advantage and innovation advantage are important mechanisms for social trust to influence foreign firms’ location choices in subnational regions. This study is important for understanding the role of subnational regional informal institutions in influencing strategic decisions of MNEs. At the same time, it has certain guiding significance for governments in attracting foreign direct investment and for multinational enterprises in selecting suitable overseas investment locations.
Development and validation of Chinese college students’ future employability scale
Authors: Chen Wanyu , Shao Kaixu , Xiao Qiuye , Mai Yilan
Published: February 2023

COVID-19 and the pandemic-induced lockdowns juxtaposed against the surge in the number of college graduates have made the dilemma of “fierce competition and difficult employment” more real. The employment of college students has become a topic of serious concern in society. This study aimed to develop a Future Employability Scale for Chinese college students and evaluate its reliability and validity. Based on the analysis of the literature, the study developed the initial measurement scale of the college students’ future employability and calibrated the initial measurement and question volume based on experts’ feedback. First, the students’ group was measured, and data from 389 university students were collected and analyzed. Second, the data collection and verification factor analysis of 387 university students were collected and verified, and the internal consistency reliability, split-half reliability, and validity of the scale were evaluated. Further, 68 college students were selected to evaluate their test-retest reliability after an interval of one month. The Future Employability Scale of college students had 28 items covering four dimensions: knowledge skill, personality quality, interpersonal network, and career development. The reliability test found that the total scale of the Future Employability Scale and the internal consistency reliability, split-half reliability, and retest reliability of each dimension were good, and the validity test suggested that the scale had good content validity, structural validity, and calibration correlation validity. With a clear structure, good reliability, and validity, the Future Employability Scale is a good tool to measure the future employability of college students.
On the distribution and interpretation of voice in Greek anticausatives
Authors: Tsiakmakis Evripidis , Borràs-Comes Joan , Espinal M. Teresa
Published: February 2023

This paper provides experimental evidence in support of the view that Greek does not have three productive morphological classes of anticausative verbs, but only two: the class of verbs that bear non-active voice morphology and the class of verbs that are morphologically active. Across two experiments, native Greek speakers are found to prefer for each anticausative verb either non-active or active voice morphological marking, in the presence or absence of explicit contextual information. It is also shown experimentally that native speakers prefer an interpretation that involves a specific cause for all anticausatives, especially when the existence of such a cause is favored by the contextual setting. Our empirical findings are consistent with the view that the Voice Phrase that is realized as non-active voice morphology in Greek anticausatives is expletive. From a theoretical perspective, we analyze the expletiveness of this Voice projection as the result of semantic redundancy: the Voice head of Greek anticausatives combines with a v head that encodes a redundant cause meaning component and is, therefore, interpreted merely as introducing an identity function.
Self-serving leadership and innovative behavior: Roles of psychological entitlement and moral identity
Authors: Mao Hongyi , Peng Shuai , Zhang Luni , Zhang Yajun
Published: February 2023

On the basis of social information processing theory, this study proposes a model of the influence mechanism of self-serving leadership (SL) on employee innovative behavior (IB), with psychological entitlement as the mediating variable and moral identity as the moderating variable. The paired data of 82 leaders and 372 employees collected at three time points are analyzed by the hierarchical linear modeling. Results corroborate that SL impairs employee IB. Moreover, the relationship between SL and employee IB is mediated by psychological entitlement. Finally, moral identity has a negative moderating effect of SL on psychological entitlement and an indirect effect on employee IB through psychological entitlement.
The mediating role of self-efficacy between workplace violence and PTSD among nurses in Liaoning Province, China: A cross-sectional study
Authors: Lu Jiachen , Yu Yingying , Wang Bin , Zhang Yanni , Ji Haoqiang , Chen Xu , Sun Meng , Daun Yuxin , Pan Yuanping , Chen Yunting , Yi Yaohui , Dou Xiaofeng , Zhou Ling
Published: February 2023

Purpose

Nurses are at high risk for workplace violence, which can lead to psychological problems. The purpose of this study was to determine the relationship between workplace violence, self-efficacy, and PTSD, and to further explore whether self-efficacy mediates the relationship between workplace violence and PTSD among Chinese nurses.

Materials and methods

This cross-sectional study was conducted in Liaoning Province, China in 2020. A total of 1,017 valid questionnaires were returned. Each questionnaire included the Workplace Violence Scale, the General Self-Efficacy Scale, the Post-traumatic Stress Disorder Scale (PTSS-10), and demographics information. A hierarchical multiple regression approach was used to explore the mediating role of self-efficacy in the relationship between workplace violence and PTSD. The mediation model was then tested by the PROCESS macro in SPSS.

Results

A total of 1,017 nurses were included in this study, and the average score of PTSD among Chinese nurses was 26.85 ± 13.13 (mean ± SD). After further adjustment for control variables, workplace violence was positively associated with PTSD, explaining 13% of the variance. High self-efficacy was associated with low PTSD, explaining 18% of the variance. Self-efficacy partially mediated the role of workplace violence and PTSD.

Conclusion

The high scores of PTSD among Chinese nurses demand widespread attention. Workplace violence is an important predictor of PTSD in nurses. Self-efficacy is a significant factor in improving PTSD in nurses and mediates the relationship between workplace violence and PTSD. Measures and strategies to improve self-efficacy may mitigate the effects of workplace violence on PTSD in nurses.
The neurocognitive basis of Chinese idiomatic constructions and processing differences between native speakers and L2 learners of Mandarin
Authors: Liu Te-Hsin , Lai Chia-Ho , Chou Tai-Li
Published: February 2023

Classic linguistic analyses assume that syntax is the center of linguistic system. Under this assumption, a finite set of rules can produce an infinite number of sentences. By contrast, construction grammar posits that grammar emerges from language use. Chinese quadrisyllabic idiomatic expressions (QIEs) offer a testing ground for this theoretical construct owing to their high productivity. To understand the cognitive processing of structure and meaning during reading comprehension, we used a semantic judgment task to measure behavioral performance and brain activation (functional MRI). Participants were 19 Mandarin native speakers and 19 L2 learners of intermediate and advanced levels of Mandarin. In the task, participants were instructed to indicate whether the interpretation of a QIE was correct. Our behavioral results showed that L2 learners processed high frequency QIEs faster than low frequency ones. By contrast, low frequency QIEs were processed faster than high frequency ones by native speakers. This phenomenon may be attributed to semantic satiation which impedes the interpretation of high frequency QIEs. To unravel the puzzle, a further functional MRI experiment on native speakers was conducted. The results revealed that the comparison of high-frequency and low-frequency QIEs promoted significant anterior cingulate activation. Also, the comparison of idiomatic and pseudo-idiomatic constructions exhibited significant activation in the bilateral temporal poles, a region that computes semantics rather than syntactic structure. This result indicated that, for native speakers, processing Chinese idiomatic constructions is a conceptually driven process.
Chinese EFL learners different from English natives in cataphora resolution: Evidence from eye-tracking studies
Authors: Wang Tao , Geng Mingyao , Wang Yue , Zhao Min , Zhou Tongquan , Yang Yiming
Published: February 2023

Previous studies on English natives have shown that encountering an English cataphoric pronoun triggers an active search for its antecedent and this searching process is modulated by syntactic constraints. It remains unknown whether the conclusion is universal to EFL (English as a Foreign Language) learners, particularly those with distinct L1 like Chinese in linguistic typology. Therefore, this study used two eye-tracking experiments to investigate how Chinese EFL learners resolve English cataphora. The experiments adopted the gender-mismatch paradigm. Experiment 1 investigated whether Chinese EFL learners with different proficiency would adopt the similar processing pattern to English natives and found that gender congruency elicited longer reading times than gender incongruency between the first potential antecedent and the cataphoric pronoun, the effect early observed in high-proficiency relative to low-proficiency learners. Experiment 2 explored whether the cataphora resolution process was modulated by Binding Principle B and revealed that longer first fixation durations and first pass reading times were observed in gender-mismatch than in gender-match conditions no matter the antecedents are binding-accessible or not while longer regression path durations occurred in gender-mismatch than in gender-match conditions only as the antecedents are binding-accessible. Taken together, these results indicate that Chinese EFL learners also adopt an active search mechanism to resolve cataphoric pronouns, yet along a processing path distinct from English natives’. Specifically, Chinese EFL learners predictively link a cataphoric pronoun to the first potential antecedent in the sentence but only a gender-matching antecedent can prompt them to engage in deep processing of the antecedent. Moreover, the processing time varies with the learners’ English proficiency. Furthermore, unlike native English speakers’ early application of syntactic constraints in their cataphora resolution, Chinese EFL learners try to establish co-reference relations between cataphoric pronouns and antecedents regardless of following or flouting Binding Principle B in early processing stages whereas they exclusively link the cataphoric pronouns to the binding-accessible antecedents in late processing stages. This study adds evidence to the Shallow Structure Hypothesis whereby L2 learners resort to lexical prior to syntactic cues to process sentences in general, which is just opposite to the fashion adopted by the natives.