bluuebunny/crossref_metadata_2025 huggingface dataset:
Eosinophils promote proliferation of pulmonary structural cells by stimulating extracellular matrix production in asthma
Authors: Rimkūnas Airidas , Januškevičius Andrius , Vasylė Eglė , Palačionytė Jolita , Janulaitytė Ieva , Malakauskas Kęstutis
Published: October 2022

Introduction. Eosinophilic asthma can be characterized by intense infiltration of eosinophils into the airways, where they abundantly release various cytokines, chemokines and growth factors. Airway remodeling is closely related to increased airway smooth muscle (ASM) mass; however, another important feature could be changes in extracellular matrix (ECM) homeostasis, driven by the production of ECM proteins and metalloproteinases by lung structural cells. Aim. To evaluate and compare eosinophil adhesion to ASM cells and pulmonary fibroblasts or their secreted ECM and the effect on pulmonary structural cell autocrine proliferation adjustment in asthma. Methods. A total of 12 allergic asthma (AA), 8 severe eosinophilic asthma (SEA) patients and 11 healthy subjects (HS) were examined. Blood eosinophils were isolated using high density Ficoll centrifugation and magnetic separation. For each study individual combined cell cultures (co-cultures) between isolated eosinophils and pulmonary structural cells or their secreted ECM were prepared. ECM purification was performed using ammonium hydroxide (NH4OH) based cell lysis. Eosinophils adhesion was evaluated by measuring eosinophils peroxidase activity in co-cultures; pulmonary structural cell proliferation was measured by AlamarBlue assay. Results. In all investigated groups eosinophil adhesion to ECM was significantly increased compared to eosinophil adhesion to ASM cells and pulmonary fibroblasts (p < 0.01). Eosinophil adhesion to ASM cells and pulmonary fibroblasts or their secreted ECM in asthma groups was significantly enhanced compared to HS group (p < 0.05). Isolated ASM cell or pulmonary fibroblast’ produced ECM after co-cultures with AA, SEA and HS eosinophils promoted newly seeded ASM cell and pulmonary fibroblast proliferation (p < 0.01) with stronger effect in both asthma groups. ECM, isolated after combined cultures with AA, SEA or HS eosinophils and the blood serum of the study patient also significantly promoted the proliferation of ASM cells and pulmonary fibroblasts (p < 0.01). Isolated ASM cell or pulmonary fibroblast’ produced ECM after co-cultures with AA and SEA eosinophils had a stronger effect to newly seeded pulmonary structural cell proliferation than after co-cultures with HS eosinophils. Conclusions. Eosinophils demonstrate enhanced adhesion to ECM components than to ASM cells or pulmonary fibroblasts, and adhesion further increases in asthma. Pulmonary structural cells promote their proliferation in autocrine manner via released ECM components after incubation with eosinophils in asthma.
Law, Spelling and Orthography
Authors: Tancheva Zornitsa
Published: October 2022

Law, Spelling and Orthography" is a modern textbook, presenting the norms of the Bulgarian literary language. It is aimed mainly at professionals in the judiciary, but can be successfully used by anyone who wants to consolidate their knowledge of spelling, punctuation and orthography. In addition to theoretical developments on the most important topics, there are also exercises to consolidate the acquired knowledge. At the end of the book there is a short dictionary of words that create spelling problems for professionals. Undoubtedly, this is a modern textbook that will make it easier for anyone who wants to write competently and express themselves more than convincingly.
IMPACT OF COVID-19 AND LOCKDOWN ON LGBTQ (IM)MIGRANTS
(WITH SPECIAL FOCUS ON INDO-AMERICAN LGBTQ COMMUNITY)
Authors: Mohanty Siba Sankar , Geeta M.
Published: October 2022

COVID-19 pandemic has made its disastrous impact on every individual of the world, it has destroyed many lives. It has created a state of emergency in the whole of the world, to protect lives thus countries decided to implement lockdown in spite of its terrible effect on the economy and financial growth of the country. On the one side, lockdown has controlled, to some extent, the transmission of Corona virus, whereas on the other side, it has created anxious as well as horrible situations among migrants or immigrants stuck in various places and countries. Marginalised individuals, groups and communities such as LGBTQ community have faced various problems in health care centres, jobs, in their host countries or places, in their return migration and even in their own families during the pandemic. Indian LGBTQ community in US has also faced discrimination in health care centres, jobs, etc. during the pandemic and lockdown. The paper makes an attempt to study and analyse the impact of COVID-19 and Lockdown on LGBTQ (Im)migrants with a focus on Indo-American LGBTQ community.
The Role of Religion in Gender Inequality in Ghana: The Christian Perspective
Authors: Frimpong Samuel Kwasi
Published: October 2022

This article seeks to discuss how religion affects gender inequality in Ghana. Religious teachings and beliefs play an important role in either promoting or hindering gender equality. Defining ‘‘religion’’ with a common definition has become a major enterprise for theologians. From the biblical perspective, the impact of females is rarely felt, due to the socio-cultural injunctions purported to have come from the Graeco-Roman world. The subjugation of women is still common in all spheres of life including Ghana and religion has a role to play in this phenomenon. Using the works of various scholars, this article explored the extent of the influence of religion on gender inequality from the Christian perspective. It was observed that despite its influence on social development, Religion has not promoted the needed gender equality in Ghana. The church and society, therefore, need to confront the issue of gender inequality and sanction women’s equality with their male counterparts. This study adds to the existing literature on the need to break gender inequality in all spheres of life in this 21st century.

Keywords: Religion, Culture, Patriarchy, Gender Inequality.
The Generalized Lipkin-Meshkov-Glick Model and the Modified Algebraic Bethe Ansatz
Authors:   Bogolyubov Institute for Theoretical Physics, Ukraine, Skrypnyk Taras
Published: October 2022

We show that the Lipkin-Meshkov-Glick 2N-fermion model is a particular case of one-spin Gaudin-type model in an external magnetic field corresponding to a limiting case of non-skew-symmetric elliptic r-matrix and to an external magnetic field directed along one axis. We propose an exactly-solvable generalization of the Lipkin-Meshkov-Glick fermion model based on the Gaudin-type model corresponding to the same r-matrix but arbitrary external magnetic field. This model coincides with the quantization of the classical Zhukovsky-Volterra gyrostat. We diagonalize the corresponding quantum Hamiltonian by means of the modified algebraic Bethe ansatz. We explicitly solve the corresponding Bethe-type equations for the case of small fermion number N=1,2.
A TWO-STAGE MATHEMATICAL PROGRAMMING MODEL FOR DISTRIBUTED PHOTOVOLTAIC PROJECT PORTFOLIO SELECTION WITH INCOMPLETE PREFERENCE INFORMATION
Authors: Zhang Zhiying , Liao Huchang
Published: October 2022

With the rapid growth of the solar photovoltaic (PV) market, many distributed PV power projects are introduced to the market. Selecting a rational project investment portfolio is a complex and challenging task for energy enterprises as both financial and non-financial factors of projects are needed to be considered under limited information and resources. This study presents a two-stage hybrid multi-attribute decision-making and integer programming model for distributed PV project portfolio selection. In Stage I, a multiple attribute group decision-making method based on mathematical programming is used to evaluate the non-financial value of projects under incomplete preference information. Compensative weighted averaging operators with an adjustable parameter are utilized to capture the subjective attitudinal character of an expert in the aggregation process. Then, a rank acceptability index is developed to measure each project’s group support degree in non-financial dimension. In Stage II, a bi-objective integer programming model is constructed to optimize project portfolios, which considers both financial and non-financial values of projects under resource, carbon emission and other strategic constraints. The applicability and effectivity of the proposed approach are demonstrated by a case study of a distributed PV project portfolio selection.
The Si K Edge Gas and Dust Optical Depths Toward the Galactic Bulge
Authors: Yang Jun , Schulz Norbert S. , Rogantini Daniele , Canizares Claude R. , Corrales Lia , Psaradaki Ioanna
Published: October 2022

Knowledge of the dust content in interstellar matter is important to our understanding of the composition and evolution of the interstellar medium. The Chandra High Energy Transmission Grating (HETG) Spectrometer provides a unique opportunity to measure X-ray absorption of interstellar dust and its compositions through the X-ray edge absorption structure. We measure gas and dust optical depths at Si K toward nine bright low-mass x-ray binaries in the Galactic Bulge with very high-precision and pileup-free spectra. We include a likely instrumental feature affecting the Si K edge structure in our analysis. While gas optical depths grow consistently with broadband hydrogen-equivalent columns, the dust optical depths do not. Calculations including dust self-shielding show that the observed dust optical depths can be explained by variations in dust grain columns between various lines of sight. At least three grain column regimes can be identified toward the Galactic Bulge. While grain sizes define the self-shielding effect, variations in grain size distributions do not seem relevant. This shows that the gas-to-dust optical depth ratio toward sources in the Galactic Bulge is not homogeneous. The dust optical depths also roughly correlate with molecular hydrogen columns. Lowly ionized Si K contributions toward the Galactic Bulge were detected but are very small. We also find Si xiii absorption with velocity widths of 800–1100 km s−1, which we attribute to the circumbinary medium.
Measuring Periods in Aperiodic Light Curves—Applying the GPS Method to Infer the Rotation Periods of Solar-like Stars
Authors: Reinhold Timo , Shapiro Alexander I. , Solanki Sami K. , Basri Gibor
Published: October 2022

Light curves of solar-like stars are known to show highly irregular variability. As a consequence, standard frequency analysis methods often fail to detect the correct rotation period. Recently, Shapiro et al. showed that the periods of such stars could still be measured by considering the Gradient of the Power Spectrum (GPS) instead of the power spectrum itself. In this study, the GPS method is applied to model light curves of solar-like stars covering all possible inclination angles and a large range of metallicities and observational noise levels. The model parameters are chosen such that they resemble those of many stars in the Kepler field. We show that the GPS method is able to detect the correct rotation period in ≈40% of all considered cases, which is more than 10 times higher than the detection rate of standard techniques. Thus, we conclude that the GPS method is ideally suited to measure periods of those Kepler stars lacking such a measurement so far. We also show that the GPS method is significantly superior to autocorrelation methods when starspot lifetimes are shorter than a few rotation periods. GPS begins to yield rotation periods that are too short when dominant spot lifetimes are shorter than one rotation period. We conclude that new methods are generally needed to reliably detect rotation periods from sufficiently aperiodic time series—these periods will otherwise remain undetected.
Pediatric Sepsis: The Importance of Understanding Criteria for Diagnosis
Authors: Sanyaolu Adekunle , Patidar Risha , Ayodele Oladapo , Marinkovic Aleksandra , Desai Priyank
Published: October 2022

Pediatric sepsis is a very significant issue for the pediatric population. Sepsis can be defined in relation to systemic inflammatory response syndrome. It can be further characterized based on the severity, including severe sepsis, septic shock, multiorgan failure, and refractory septic shock, in the setting of proven infection or suspected infection. In the pediatric population, sepsis is a complicated and dangerous event with no one specific criteria or definition in the systemic inflammatory response syndrome criteria applicable to every child who is suffering from the condition. The goal of this paper is to enhance awareness of the various forms and severities of sepsis in the pediatric population so that swift diagnosis can be made and treatment can be initiated. An electronic literature review search was performed, and relevant data were collected from peer-reviewed articles from January 2005 to May 2020. The nonspecific nature of this condition can manifest as cardiovascular dysfunction, and hematologic abnormalities to neurologic symptoms, resulting in a late diagnosis, which ultimately leads to an increase in mortality and morbidity. The implications of sepsis in the pediatric population needs to be addressed. It is imperative for all medical professionals, including medical students, to understand the criteria and to raise a high level of suspicion when presented with a child exhibiting symptoms that may indicate sepsis. By increasing awareness of pediatric sepsis, complications, including death, that arise as a result of late diagnosis and treatment would be substantially decreased.

[
Pediatr Ann
. 2022;51(10):e405–e408.]
Process of Advance Care Planning in Nursing Home Settings: An Integrative Literature Review
Authors: Muthui Rachel , Paun Olimpia
Published: October 2022

Advance care planning (ACP) allows individuals to communicate their wishes for future medical care. ACP is particularly important among those diagnosed with Alzheimer's disease and related dementias (ADRD) due to decline in cognition. In the nursing home setting, conducting ACP with residents with ADRD and their family caregivers is challenging. The purpose of the current integrative review was to: (a) examine the evidence on the process of conducting ACP with residents with ADRD and their family care-givers in nursing home settings, and (b) understand who conducts ACP and when and how ACP is being conducted with residents with ADRD and their family caregivers. Gaps were identified, such as lack of a systematic approach to addressing ACP in nursing homes, lack of clear roles in conducting ACP, family caregivers' and nursing home staff's lack of knowledge and skills to engage in ACP, and lack of diversity in study samples. To improve clinical practice, future studies should explore standardization of the ACP process in the nursing home setting. [
Research in Gerontological Nursing, 15
(6), 312–320.]
Assessing the Potential of Mechanical Aeration Combined with Bioremediation Process in Soils and Coastal Sediments Impacted by Heavy Metals
Authors: Mungla Gireshsingh , Facknath Sunita , Lalljee Bhanooduth
Published: October 2022

Microorganisms make use of heavy metals through enzymatic, non-enzymatic processes or bioaccumulation in bacterial cells in insoluble or particulate forms and by-products. Increasing effectiveness of bioremediation is still being explored and other stimulation techniques cited by various authors used mostly EDTA, nitrogen fertiliser and other amendments. The use of mechanical aeration combined with bioremediation using Bacillus subtilis, Bacillus cereus, Pseudomonas aeruginosa and Pseudomonas fluoresecens offer a greener approach with more efficient remediation capabilities. Zinc exceeded the permissible limit recommended by FAO/WHO by more than two folds while other metals were close to the threshold limit posing a dangerous threat to human health. Implementation of the current package treatment showed statistically significant decreases in heavy metal concentrations in both soils and coastal sediments in a 90 days experiment under atmospheric conditions. For sediments, 21.4% to 100% bioremediation was achieved under mechanical aeration conditions representing an increase of up to 60% efficiency compared to non-aeration while for soil highest efficacy achieved was 63.1%. However, the mechanisms and pathways of bioremediation were noticed to depend according to biotic and abiotic factors. This article provides an insight on the comparison between proposed stimulation technique and other methods reported.
A sequential estimation problem with control and discretionary stopping
Authors: Ekström Erik , Karatzas Ioannis
Published: October 2022

We show that “full-bang” control is optimal in a problem which combines features of (i) sequential least-squares estimation with Bayesian updating, for a random quantity observed in a bath of white noise; (ii) bounded control of the rate at which observations are received, with a superquadratic cost per unit time; and (iii) “fast” discretionary stopping. We develop also the optimal filtering and stopping rules in this context.
A REVIEW OF WIND-ASSISTED SHIP PROPULSION FOR SUSTAINABLE
COMMERCIAL SHIPPING: LATEST DEVELOPMENTS AND FUTURE STAKES
Authors: Khan L , Macklin J J R , Peck B C D , Morton O , Souppez J-B R G
Published: October 2022

With the current global warming crisis and contemporary concerns for sustainability, the transport industry is developing and implementing novel solutions to reduce greenhouse gases. With close to 90% of the world’s goods relying on maritime
transportation, responsible for 3% of global energy-related carbon dioxide (CO2) emissions in 2019, there is a vital emphasis on reducing emissions. The latest legislation from the International Maritime Organisation has imposed even
tougher sulphur oxide targets. On the other hand, emission intensity for CO2 will need to be decreased by 70% in 2050, compared to 2008 figures. While operating measures and fuel alternatives are suitable in the short-term to meet these novel regulatory constraints, as the use of fossil fuels tapers off, the long-terms solution appears to reside in wind-assisted ships. Consequently, this study aims to identify viable solutions that could reduce emissions, focussing on three prominent technologies, namely sails, rotors and kites. Furthermore, this review provides guidance on the benefits and risks
associated with each technology and recommends guidelines for performance prediction and associated constraints. Ultimately, future stakes in wind-assisted propulsion are highlighted, including the need for full-scale validation, the
challenge in assessing environmental and economic impact, and the structural issues associated with wind-assisted propulsion systems.
A CFD STUDY ON WIND ASSISTED PROPULSION TECHNOLOGY FOR COMMERCIAL SHIPPING
Authors: Hopes W C P , Pearson D R , Buckingham J E
Published: October 2022

Wind assisted propulsion has the potential to significantly reduce emissions from global shipping, with a range of technologies available including wing sails, kites, Flettner Rotors, and Suction Aerofoils such as Turbosails. Despite this, there are only a few studies publicly available on the performance of Suction Aerofoils, which operate on the same principle as a traditional sail but use boundary layer suction to develop high lift coefficients. Therefore, a CFD study was carried out in Numeca FINE/Marine software to determine values for the lift and drag coefficients over a range of angles of attack and suction levels. Supplementary studies also investigated the effects of introducing an endplate to reduce end vortices, and the effect of a ship side on the wind speed incident on the Suction Aerofoil. The plots of lift and drag coefficients developed in this paper were used to inform the BMT-led VTAS project [1], as well as contributing to wider knowledge on wind assisted propulsion for shipping. Throughout the study, Suction Aerofoils continued to show promise as an effective means of auxiliary propulsion for ships, and their use should be encouraged as part of the range of solutions to tackle the pressing issue of climate change.
Logistics: Views and Definitions
Authors: Dekker R. , Van den Berg P. H.
Published: October 2022

Logistiek — wat is dit? 'n Nuwe konsep of slegs 'n nuwe woord vir bestaande idees? In hierdie artikel poog die skrywers om verskillende definisies oor Logistiek saam te vat en daaruit hul eie definisie voor te stel. 'n Kort oorsig word ook gegee van die ontwikkeling en ontstaan van Logistiek.
Преобразование Беклунда и его применение для решения уравнения Вахненко
Authors: Xue Min , Mao Hui
Published: October 2022

Строится и изучается преобразование Беклунда, содержащее как независимые, так и зависимые переменные, для уравнения Вахненко. При этом используются преобразование взаимности и ассоциированное уравнение Вахненко. Получена соответствующая нелинейная формула суперпозиции, т. е. двукратное и трехкратное преобразования Беклунда, которые можно переписать в терминах пфаффианов. Также обсуждается аналогичное представление для общего $N$-кратного преобразования Беклунда. В качестве приложений найдены некоторые явные решения уравнения Вахненко.
Antimicrobial Resistance Profile of Bacteria Causing Pediatric Infections at the University Teaching Hospital in Rwanda
Authors: Munyemana Jean Bosco , Gatare Bright , Kabanyana Pauline , Ivang Andrew , Mbarushimana Djibril , Itangishaka Innocent , Niringiyumukiza Jean Damascene , Musoni Emile
Published: October 2022

Bacterial infections pose a global threat, especially in the pediatric population. Antimicrobials that are used to treat such infections continuously show reduced efficacy, and empirical therapy is a major treatment option in Rwanda. This study aimed to determine the resistance rate of commonly used antibiotics in pediatric patients. The study was conducted from June 1, 2018 to May 30, 2019, and microbiological samples were collected from 712 children with suspected bacterial infections. Antimicrobial sensitivity testing was performed on 177 positive cultures (24%) that were considered for data analysis. The findings show that the major bacterial isolates were Klebsiella pneumoniae (n = 50, 28.2%), Escherichia coli (n = 47, 26.5%), and Staphylococcus aureus (n = 38, 21.4%). In general, the greatest antibiotic resistance rate was observed in ampicillin (n = 125, 86.2%), amoxicillin–clavulanic acid (n = 84, 82.4%), amoxicillin (n = 64, 79%), cefadroxil (n = 83, 69.2%), tetracycline (n = 72, 59.7%), ceftazidime (n = 42, 55.3%), and cefuroxime (n = 14, 53.8%). More specifically, Klebsiella pneumoniae was 100% resistant to amoxicillin-clavulanic acid, cefuroxime, trimethoprim–sulfamethoxazole, ceftazidime, erythromycin, and clindamycin. Staphylococcus aureus was 86.7% resistant to ampicillin, and Escherichia coli was 91.7% resistant to tetracycline, 90.6% resistant to ampicillin, 83.3% resistant to amoxicillin–clavulanic acid, 79.3% resistant to cefadroxil, and 78.6% resistant to ceftazidime. Moreover, Klebsiella pneumoniae from blood and urine was 96.8% and 100% sensitive, respectively, to meropenem. Staphylococcus aureus from blood was 100% sensitive to vancomycin, whereas Escherichia coli from urine was sensitive to clindamycin (100%), nitrofurantoin (80.6%), and ciprofloxacin (72.7%). In conclusion, our findings show a high resistance rate to commonly used antibiotics, which suggests precaution in empirical therapy and continued surveillance of antimicrobial resistance.
Does Calcified Neurocysticercosis Affect Migraine Characteristics and Treatment Responsiveness? A Case–Control Study
Authors: Sharma Kamini , Uniyal Ravi , Garg Ravindra Kumar , Verma Rajesh , Paliwal Vimal Kumar , Malhotra Hardeep Singh , Sharma Praveen Kumar , Kumar Neeraj , Pandey Shweta , Rizvi Imran
Published: October 2022

Recently, inflammation and free-radical release has been described in the surrounding brain parenchyma of seemingly inert calcified lesions of neurocysticercosis. These free radicals can induce migraine by stimulating calcitonin gene-related peptide release. This stipulated mechanism led us to hypothesize that calcified neurocysticercosis may increase migraine severity. This case–control study included patients (migraine with calcified neurocysticercosis) and control subjects (migraine without calcified neurocysticercosis) in a 1:1 ratio. Headache frequency, visual analog scale (VAS) score, and Migraine Disability Assessment (MIDAS) score were assessed at baseline and at the end of 3 months. To compare treatment responsiveness between patients and control subjects, we treated both groups identically so that difference in treatment would not confound the results. Each group comprised 78 patients. Baseline headache frequency (11.3 ± 3.3 versus 7.9 ± 3.4), VAS score (7.5 ± 1.1 versus 6.0 ± 1.2), and MIDAS score (15 ± 7.6 versus 9.6 ± 4.5) were significantly greater in patients than control subjects. Interestingly, the change from baseline to the end of 3 months in headache frequency (6.0 ± 1.7 versus 2.8 ± 1.4), VAS score (2.6 ± 0.02 versus 1.4 ± 0.01), and MIDAS score (8.3 ± 5.0 versus 3.6 ± 2.0) were significantly greater in patients than control subjects. Our study emphasizes that calcified lesions of neurocysticercosis are not inert, and cause an increase in the frequency and severity of migraine attacks. Interestingly, these patients also showed a better response to treatment with amitriptyline, possibly resulting from its anti-inflammatory action. Further studies are warranted to explore possible inflammatory mechanisms in calcified neurocysticercosis, which influences migraine physiology.
Modified Stoppa Approach For Concomitant Anterior And Posterior Pelvic Ring Fracture: A case report
Authors: Wibowo Arif - , Chilmi Mohammad Zaim
Published: October 2022

BACKGROUNDModified Stoppa approach was performed to access the site of anterior column fracture instead of the Ilioinguinal approach to reduce morbidity.CASE SUMMARYA 24-year-old female suffered a serious traffic accident when she was riding a motor cycle collided with a car from the front and fell off when dodged a hole on the road. Then, the patient was beneath a moving car after falling. Several hours after accident at the hospital, she diagnosed as closed pelvic fracture of right superior inferior pubic rami and right sacroiliac joint disruption, closed fracture of right shaft femur. After improvement the condition in the ward, open reduction and internal fixation for the femoral fracture and for the pelvis fracture were performed using a modified stoppa approach to access the fracture site.CONCLUSION Treatment using the modified Stoppa approach was suitable for anterior column fracture, in which pelvic fractures were sufficiently exposed, the fracture was conveniently reduced, less complications occurred, and curative effect was satisfactory.
AO Reconstruction Plate as Buttressing for Greater Trochanter in Hemiarthroplasty Procedure
Authors: Hidayat Luthfi , Robby Triangga Aditya Fuad , Magetsari Rahadyan
Published: October 2022

INTRODUCTIONThe trend of intertrochanter fractures has gradually increased leading to a high frequency of difficulties and damage as the result of the increased age and risk factors. Accordingly, the aim of stable fixation in these fractures is designed with appropriate surgical procedures and patient care. The contribution of a stable fixation is due to several considerations including fracture shape and assurance, bone quality, comminution pattern, implant choice, and surgical technique. This study aimed to assess the functional outcomes of the patients with an intertrochanteric fracture who underwent hemiarthroplasty with AO recon as buttressing.MATERIALS AND METHODSThis was a case series study conducted in Gadjah Mada University Academic Hospital in Yogyakarta from July 2017 to August 2018. Patients with Evans unstable intertrochanteric femoral fractures who underwent simultaneous bipolar hemiarthroplasty and fixation with AO reconstruction plate and SS wire as buttressing were evaluated. Pre and postoperative radiographs, postoperative Visual Analog Scale (VAS) score, walking ability using Harris Hip Score (HHS), and Lower Extremity Functional Score (LEFS) were the outcome parameters.RESULTSA total of 6 patients, 4 of whom were male with an average age of 81 years old were included in this study. All the mechanisms of injury were low-energy trauma. The mean VAS score was decreased, from 7 pre-operatively to 1.5 post-operatively at final follow-up (p-value 0.05). The patients had a mean HHS of 82.5 and a LEFS mean of 56.7.CONCLUSIONButtress plate fixation using an AO reconstruction plate for trochanteric fracture following bipolar hemiarthroplasty resulted in a good functional outcome.
Golden Connection Between Stem Cells and Orthopedic Services
Authors: Rhatomy,MD Sholahuddin , Santoso Asep , Phatama Krisna Yuarno , Budhiparama Nicolaas C.
Published: October 2022

Utilization of stem cells in orthopedics has increased dramatically. Consequently, stem cells were discovered to have many roles. Some researchers have used them for regenerative medicine, while some have discovered them as a natural source of immune modulators. Currently, there are several research teams studying the translational potential of stem cells, while clinicians have begun treating patients with orthopedic problems (1).Over the past fifteen years, orthopedic surgeons have prioritized Mesenchymal Stem Cell (MCSs) treatment. Several animal experiments have had favorable results, and there is rising concern over their use in human trials. In these clinical studies, stem cell operations were intended to promote fracture healing and cure nonunion, regenerate articular cartilage in degenerated joints, repair ligament or tendon injuries, and replace degenerative spinal disks (1,2).In past research, stem cells have been used for bone tissue regeneration. Bone tissue engineering presents an alternative treatment that may produce a micromilieu with osteogenic, osteoinductive, and osteoconductive properties. In recent studies, researchers have devised methods for combining MSCs with three-dimensional biodegradable polymeric scaffolds. In addition, Udehiya et al. found that the use of hydroxyapatite scaffolds in conjunction with Bone Marrow-MSCs (BM-MSC) accelerates and enhances the healing of bone segmental defects in a rabbit model compared to the use of hydroxyapatite scaffolds alone. Muwan Chen and colleagues discovered that human BM-MSC combined with hyaluronic acid and b-Tri calcium phosphate-coated polymeric scaffold stimulated osteogenic differentiation, cellular proliferation, and reorganization of the cellular matrix in vitro (1–3).Since 2010, stem cells have undergone a paradigm shift where previously stem cells can differentiate and heal injured organs. This stem cell misunderstanding has led some practitioners in the United States and around the world to advertise the availability of stem cell treatments, e.g., MSC can heal blindness, make paralyzed people walk, and makes old tissue young again. In further studies, it was found that at the site of disease, MSCs rarely or never differentiated into tissue at that location, but they do secrete bioactive factors such as growth factors and their therapeutic effects can be analyzed as a site-specific clinical outcome parameter (2–4).
Mesenchymal Stem Cells Secretome and Osteoarthritis: A State of The Art
Authors: Soetjahjo Bintang , Utomo Dwikora Novembri
Published: October 2022

No agreed cure or procedure can prevent the damage caused by OA. Current treatments such as physiotherapy, anti-inflammatory drugs, and viscous supplements are symptomatic and are aimed solely at pain relief. Mesenchymal stem cells, on the other hand, refer to a population of cells with immunomodulatory and homing properties. Recent studies have shown that stem cells produce secretomes with tissue regeneration, immunomodulation, anti-inflammatory, and anti-apoptotic capacities.Secretomes in conditioned media produced by mesenchymal stem cells can stimulate the repair of cartilage defects. There are many evidence from many studies both in vitro and in vivo which provide potential results. The improvement can be seen from the morphology, in the form of thickening of the cartilage, an increase in the number of chondrocyte cells, regular joint surfaces, and histologically it can be seen that there is an improvement in the joint cartilage matrix. Likewise, histological studies using immunohistochemistry also showed an increase in the expression of TGF-β, SOX-9, aggrecan, and type II collagen which is a pathway for the formation of hyaline cartilage repair. Not only improvement, other studies have also shown that the secretome can provide a protective effect on joint cartilage by increasing the expression of the COL2A1 gene which functions to form collagen matrix components and reduces apoptosis in chondrocyte cells.Secretomes produced by mesenchymal stem cells can stimulate the repair of cartilage damage, anti-inflammatory, immunomodulator, angiogenesis, and anti-apoptotic abilities from their cytokines and extra vesicles contains miRNA. MSCs secretomes are more stable and provide simpler manufacturing than MSCs themselves.
Editorial
Authors: Salcedo Beltrán Carmen
Published: October 2022

Presentación del volumen 12, número 2, 2022.
sindicalismo y sus instrumentos de acción colectiva en la concepción de Georges Sorel. Un estudio crítico
Authors: Monereo Pérez José Luis
Published: October 2022

Para Georges Sorel, el porvenir del socialismo (autogestionario y antiestatalista) reside en el desarrollo autónomo de los trabajadores y los sindicatos obreros. El proletariado debe adquirir plena conciencia de clase y articular una estrategia que le permita derribar todo el entramado del sistema del capitalismo. En la ideología sindicalista de Sorel, el objetivo final consistía ante todo en la autogestión por los trabajadores a través de las instituciones sindicales vertebradas en el tejido productivo. En ese objetivo de autogestión de los trabajadores el sindicato está llamado a ejercer una labor de cristalización de experiencias y una labor pedagógica. De ahí se gestará el nuevo modelo de organización social y la nueva moral de los productores como alternativa  al sistema del capitalismo. Mientras el marxismo ortodoxo afirmaba los límites de la conciencia sindical haciendo del partido la institución y el instrumento determinante de la lucha de los trabajadores por una nueva sociedad, Sorel, la encuentra en el sindicalismo revolucionario y autogestionario, capaz de construir un orden que desplazaría al Estado centralizado, al sistema de partidos y a la democracia parlamentaria. El poder del trabajo se expresa en la lucha. Según Sorel el hombre es ante todo homo-faber, siendo la razón hija de la técnica. El hombre está vinculado a su condición de productor. En el desarrollo del proceso de producción reside el conocimiento de los fenómenos y los valores de referencia, no en el intelectualismo externo a la misma. Comprender es producir, de manera que el que no produce es un parásito. De ahí que el porvenir socialista resida en la constitución autónoma de una “sociedad de productores”, es decir, la verificación hasta sus últimas consecuencias de una clase que adquiere conciencia de clase “para sí”, forjada en una nueva moralidad y en el derrocamiento del Estado capitalista. Son las instituciones autónomas de los trabajadores como “clase para sí” el auténtico agente de la revolución, no los partidos políticos de vanguardia “profesionalizados”.
ciencia jurídica en la crisis del constitucionalismo democrático: Hans Kelsen
Authors: Monereo Pérez José Luis
Published: October 2022

Kelsen desarrolló su teoría de la democracia y del Estado en la época de la “crisis de la democracia”, en la que florecieron diversas teorías de la democracia alternativas, con el trasfondo de la experiencia crítica de la República Democrática de Weimar. Desde entonces las reflexiones sobre la crisis de la democracia y la multiplicidad de teorías de la democracia no han hecho sino proliferar como un compañero de viaje crítico de las sociedades contemporáneas. La teoría del Derecho remite ya a una actividad que no se limita a describir y sistematizar el Derecho, sino que también toma en consideración abiertamente la reformulación del ordenamiento jurídico, de modo de proveer a los operadores jurídicos de un sistema de soluciones técnico-jurídicas y las necesarias soluciones axiológicas (que en el fondo ya están presentes en las normas de principios y valores constitucionalmente consagrados). En cuanto a la caracterización de la ciencia jurídica debe quedar de principio clara la idea de que históricamente está superado el formalismo jurídico absoluto, es decir, la pretensión de limitar el objeto de conocimiento jurídico al Derecho vigente, pues en la conexión entre el Derecho y la realidad social se impone un realismo normativista para captar el fenómeno jurídico en toda su complejidad dentro de los órdenes de la vida y servir, así, a las exigencias de organización y racionalización jurídica de las relaciones sociales con arreglo a fines y principios garantizados por textos de valor y “sentido constitucional”.
Retos pendientes en la protección del embarazo y de los derechos de conciliación de la vida familiar y laboral frente al despido
Authors: Roldán Martínez Aránzazu
Published: October 2022

La legislación española cuenta con instituciones, instrumentos y técnicas jurídicas para la protección de la situación de embarazo y de los derechos de conciliación de la vida familiar y laboral que la sitúan entre los Estados más avanzados de nuestro entorno. Las sucesivas reformas legislativas que arrancaron con la Ley 39/1999 y han concluido con el Real Decreto-Ley 6/2019, han reforzado la protección de estos derechos, añadiendo a la tradicional tutela discriminatoria una segunda tutela objetiva y automática que ha mejorado de forma notable las previsiones de las Directivas comunitarias. Sin embargo, la frontera entre ambos tipos de tutela, su configuración jurídica y alcance, así como la correcta identificación de las situaciones protegidas, no resulta del todo clara. Por otro lado, en el caso de mujer embarazada, que haya dado a luz o en período de lactancia natural nuestro ordenamiento jurídico podría no haber transpuesto correctamente el art. 10.1 de la Directiva 92/85. La revisión de las sentencias recaídas en las distintas instancias judiciales nos permitirá conocer los problemas que en la práctica está planteando la aplicación del segundo párrafo de los arts. 55.5 y 53.4 ET e identificar los retos que quedan pendientes en esta materia.
Food Hygiene Rating Scheme Audit of Display and Business Survey 2021
Authors: Research IFF
Published: October 2022

Under the Food Hygiene Rating Scheme (FHRS), places where food is supplied, sold or consumed are given a rating ranging from 0 to 5, with 5 indicating ‘very good’ food hygiene and 0 indicating ‘urgent improvement necessary’. In Northern Ireland and Wales, businesses are legally required to display their food hygiene rating sticker in a prominent place like the front door, entrance or window of the business. Businesses in England do not have to display their rating at their premises but are encouraged to do so. Across England, Northern Ireland and Wales, food hygiene ratings are also available to search on the FSA website. The Food Standards Agency (FSA) has conducted research into the Display of Food Hygiene Ratings in England, Northern Ireland and Wales since 2011, although the research was paused in 2020 due to COVID-19 pandemic. In 2021, the FSA commissioned IFF Research to update the research with the following aims: Provide a representative estimate of the display of food hygiene ratings by food businesses Explore the reasons and drivers for display and non-display Explore business awareness and attitudes towards the scheme Fieldwork in November and December 2021 comprised 1,522 covert audits of food businesses in England, Wales, and Northern Ireland and 1,500 telephone interviews of food businesses.
REDESAIN PASAR SEPINGGAN BALIKPAPAN PENEKANAN PADA PENCAHAYAAN DAN PENGHAWAAN ALAMI
Authors: Hakim Bhanu Rizfa , Hs Cisyulia Octavia , Pangasih Felixs Dinata , Sadikin Andi Alif
Published: October 2022

Di kota Balikpapan terdapat banyak pasar tradisional, salah satunya adalah Pasar  Sepinggan Balikpapan.Meredesain Pasar Sepinggan Balikpapan agar mampu  mewadahi aktifitas jual-beli dengan penerapan Pencahayaan dan Penghawaan  alami.Metode yang digunakan dalam Redesain Pasar Sepinggan, lebih menekankan  pada penerapan Pencahayaan dan Penghawaan Alami serta sistem utilitas pada  pasar. Selain itu terdapat beberapa literatur yang dapat digunakan dan menjadi  standar dalam proses redesain Pasar Sepinggan Balikpapan. Pasar Sepinggan  Balikpapan merupakan salah satu pasar tradisional yang ramai pengunjung di Kota  Balikpapan , karena terkenal dengan harga yang lebih murah dari pasar lain , namun  penataan para pedagang masih belum dilakukan dan pola parkir yang tidak beraturan menimbulkan kemacetan pada pagi dan sore harikonsep penataan kembali baik dari segi bangunan , zonasi dan layout ruang pada pasar tersebut ,pertimbangan arsitektur yang diberikan akan menghasilkan sebuah desain yang membentuk sebuah suasana yang berbeda dari sebelumnya untuk mengikat minat pengunjung dan memberikan kenyamana pada aktifitas jual-beli yang terjadi.
Systematic Review Keakuratan Underlying Cause of Death (UCOD) pada Sertifikat Kematian di Fasilitas Pelayanan Kesehatan
Authors: Rusdi Achmad Jaelani , Prisusanti Retno Dewi , Ularan R.A. Rengganis
Published: October 2022

AbstractDeath certificates are an important source of mortality and statistical data, affecting the quality of service. Therefore, it must be as accurate as possible to reflect the quality of existing health services. This study aims to analyze the accuracy of death certificates in health care facilities using five years of research data from journals published in the 2017-2020 range. This study accumulates and integrates existing studies of 15 articles as a sample. The results showed that the number of accurate death certificates in health care facilities was 49.82%, while the inaccurate data on death certificates was 50.18%. Accuracy data include completeness, legibility, and accuracy in determining the Underlying Cause of Death (UCOD). This shows the low accuracy of data on the causes of patient death and affects mortality statistics in health care facilities. Therefore, training and assistance for codifying and determining UCOD on death certificates should be sought at every health care facility, and further research to improve the accuracy of UCOD on death certificates.Keyword: Death Certificate, Healthcare Facilities, UCOD AbstrakSertifikat kematian merupakan sumber data penting tentang kematian dan data statistik, hal ini berpengaruh dengan mutu pelayanan, Oleh karena itu harus seakurat mungkin sehingga mencerminkan mutu pelayanan kesehatan yang ada. Penelitian ini bertujuan untuk menganalisis keakuratan sertifikat kematian di fasilitas pelayanan kesehatan dengan menggunakan 5 tahun data penelitian dari jurnal yang dipublikasi dengan rentang tahun 2017-2020. Penelitian ini mengakumulasi dan mengintegrasikan studi yang telah ada terhadap 15 artikel sebagai sampel. Hasil penelitian menunjukkan bahwa jumlah sertifikat kematian di fasilitas pelayanan kesehatan yang akurat sebesar 49,82%, sedangkan data yang tidak akurat pada sertifikat kematian sebesar 50,18%. Data keakuratan meliputi kelengkapan, keterbacaan dan ketepatan dalam penentuan Underlying Cause of Death (UCOD). Hal ini menunjukkan rendahnya keakuratan data penyebab kematian pasien dan mempengaruhi statistik kematian di fasilitas pelayanan kesehatan. Pelatihan dan pendampingan kodifikasi dalam penentuan UCOD pada sertifikat kematian harus diupayakan pada setiap fasilitas pelayanan kesehatan serta penelitian selanjutnya guna meningkatkan keakuratan UCOD pada sertifikat kematian.Kata Kunci: Sertifikat Kematian, Fasilitas Pelayanan Kesehatan, UCOD
Application of geoinformation mapping methods for urbanized territories using remote sensing data
Authors: Artemeva Olga V. , Pozdnjakova Nataliya A. , Gnevashev Fiodor A.
Published: October 2022

The article considers examples of mapping urban areas using remote sensing data (Landsat 4-5, 7, 8 and Sentinel 2) based on the QGIS open information system. On the basis of several projects carried out at the Institute of Earth Sciences of St. Petersburg State University, the main steps of remote sensing data processing and the use of GIS are shown, as well as significant differences in details, which vary depending on the purpose of the project and the study area. The authors performed data processing and analysis, as well as dynamic mapping of the city of Volgograd, a settlement with a linear urban planning with a large extent, studied the ecological state (in particular, analysis of thermal anomalies) and compiled a map of the city of Balakovo as a city-forming nuclear center of the Saratov region of the Russian Federation, analyzed the recreational areas of the cities of the Stavropol Territory, and also compiled the urbanized territories of one of the foreign states of the Asia-Pacific region. Attention is focused on the relevance and necessity of popularization in the management circles of algorithms and methods for using available software and open data to improve the efficiency of decisions made in various regions of the Russian Federation.
GIS INTEGRO: new opportunities for training students in geological and geophysical fields
Authors: Toloknova Kristina V. , Drovninov Dmitry A. , Lyubimova Anna V.
Published: October 2022

The article discusses modern innovative opportunities for the preparation of students of geological and geophysical directions. The article focuses on the feasibility of applying information technologies in the process of training. The review of the block of processing of downhole information of the GIS INTEGRO software complex in the context of its use in the educational process is carried out.
Complication in Neglected Non-Venomous Snake Bite in Rural Area; What We Need to Anticipate
Authors:   Rantau Suli Public Health Center, East Jangkat, Jambi, Indonesia, Ulima Almira Talitha
Published: October 2022

Snake bite is common condition that lead to great consequence in the rural area of tropical country. Although snakebite is treatable, WHO listed snakebite as Neglected Tropical Disease. Epidemiology data of snakebite not known exactly, the real data may be higher than data inscribed. Both venomous and non-venomous snake are can lead to fatal condition and make the victim consequences morbidity and mortality. Non-venomous snakebite also have potential risk of infection, coagulopathy, and traumatic feelings. Prognosis affected by many factors from snake venom, the victim, and environment that led to delayed medical treatment. Here, we report a case of neglected non-venomous snakebite wound that lead to severe infection of the limb.