bluuebunny/crossref_metadata_2025 huggingface dataset:
Obstructive Sleep Apnea in a Clinical Population: Prevalence, Predictive Factors, and Clinical Characteristics of Patients Referred to a Sleep Center in Mongolia
Authors: Dashzeveg Shuren , Oka Yasunori , Purevtogtokh Munkhjin , Tumurbaatar Enkhnaran , Lkhagvasuren Battuvshin , Luvsannorov Otgonbayar , Boldbaatar Damdindorj
Published: November 2021

Obstructive sleep apnea (OSA) disrupts sleep. This study examined factors related to OSA severity. A cross-sectional, prospective, hospital-based study was conducted with 205 patients who underwent polysomnography (PSG). Demographic, anthropometric, clinical, PSG, and sleep quality assessment data were analyzed. Participants (N = 205) were classified into four groups based on apnea–hypopnea index (AHI); no OSA (AHI < 5/h; N = 14), mild (mOSA, 5 < AHI < 15/h; N = 50), moderate (modOSA, 15 < AHI < 30/h; N = 41), severe (sOSA, 30 < AHI < 60/h; N = 50), and very severe (vsOSA, AHI ≥ 60; N = 50). Men had more severe OSA than women (p < 0.001). Anthropometric characteristics differed with OSA severity (p < 0.001). OSA patients had decreased sleep quality and increased excessive daytime sleepiness (EDS). Body mass index (BMI), neck/waist circumference, and blood pressure (BP) differed between groups (p < 0.001). Patients with vsOSA had the highest Mallampati grades (p < 0.001). Multiple linear regression indicated that OSA severity was related to gender and sleep quality. PSG parameters (oxygen saturation, systolic BP, and arousal/respiratory arousal) were strongly related to OSA severity. In conclusion, about half of study-referred patients had severe/very severe OSA; these groups were predominantly obese men with high BP. OSA severity associated with high BP, BMI, waist circumference, and neck circumference.
Rehabilitation Programs for Bedridden Patients with Prolonged Immobility: A Scoping Review Protocol
Authors: Parola Vitor , Neves Hugo , Duque Filipa Margarida , Bernardes Rafael A. , Cardoso Remy , Mendes Carla A. , Sousa Liliana B. , Santos-Costa Paulo , Malça Cândida , Durães Rúben , Parreira Pedro , Apóstolo João , Cruz Arménio
Published: November 2021

Bedridden patients usually stay in bed for long periods, presenting several motor problems caused by immobility, such as reductions in muscle mass, bone mineral density and physical impairment, resulting in a long recovery process. Thus, identifying physical rehabilitation programs for bedridden patients with prolonged immobility is a matter of urgent research for a solution that will help health professionals and stakeholders to develop more adjusted programs and identify possible gaps. To date, no previous scoping reviews addressing this purpose have been found. This scoping review will be guided by the Joanna Briggs Institute (JBI) methodology, will focus on physical rehabilitation programs for bedridden patients with prolonged immobility and aims to map the programs, the devices used, and the parameters assessed. A relevant set of electronic databases and grey literature will be searched. Data extraction will be conducted using a tool developed by the research team that will address the review objectives and questions. Data synthesis will be presented in tabular form and a narrative summary aligned with the review’s objective. This scoping review will contribute to the improvement of clinical practice, identifying key challenges that might justify the need to develop new programs suitable in clinical and organizational contexts.
Stress Impact of COVID-19 Sports Restrictions on Disabled Athletes
Authors: Fiorilli Giovanni , Buonsenso Andrea , Davola Nicola , Di Martino Giulia , Baralla Francesca , Boutious Stefanos , Centorbi Marco , Calcagno Giuseppe , di Cagno Alessandra
Published: November 2021

The stress impact of COVID-19 restrictions has put the adapted sports community at an unprecedented level of emergency. The self-report Event Scale—Revised (IES-R) questionnaire was administered to assess the level of psychological distress and emotive reactions such as intrusion (INT), avoidance (AV) and hyperarousal (HYP) following training and competitions suspension within a sample of Italian disabled athletes. A total of 146 self-selected volunteers were included in this study: 73 disabled athletes (aged 42.11 ± 13.70) and 73 athletes (aged 40.23 ± 13.73) who served as the control group. Only 8.22% of the disabled participants vs. 30.14% of athletes were affected by subjective distress. MANOVA showed significant differences in IES-R subjective distress for age, where the emerging adults had a higher level of stress than adults (p = 0.031), and for the type of sport, where the individual sports group showed higher scores than the team sports group (p = 0.049). Regarding the IES-R subscales, significant differences were found in INT and AV for age, where the emerging adults showed higher scores than adults (p = 0.018 and p = 0.046, respectively). Significant differences were found in HYP for type of sport, where the individual sports group showed higher scores than the team sports group (p = 0.014). The results confirmed a lower distress level of disabled athletes to adverse events than that expressed by athletes. Both sports engagement and the experience of living with impairment, overcoming structural barriers, could act as a buffer effect against stress due to COVID-19 restrictions.
Parent-Child Discrepancies in Perceived Parent-Child Communication and Depressive Symptoms in Early Adolescents in China
Authors: Zhang Qiongwen , Shek Daniel T. L. , Pan Yangu
Published: November 2021

Although recent studies demonstrated that parent-child discrepancies in the perceived family processes were associated with children’s developmental outcomes, few studies have addressed this issue in different types of families in mainland China. The present study investigated that how discrepancies in parents’ and adolescents’ perceptions of parent-adolescent communication were associated with early adolescent depressive symptoms in a nationally representative sample (N = 15,377) with 7010 father-adolescent dyads (adolescents: Mage = 14.24 years, SD = 1.25 years; 5960 adolescents from two-parent families, 443 adolescents from single-father families) and 8367 mother-adolescent dyads (adolescents: Mage = 14.02 years, SD = 1.18 years; 6670 adolescents from two-parent families, 1362 adolescents from single-mother families) in China. Adolescent respondents completed a measure of depressive symptoms and all informants reported on the perceived levels of parent-adolescent communication. Results indicated that adolescents reported parent-child communication more negatively than did their parents. Father-adolescent discrepancies were also greater in intact families than non-intact families. Polynomial regression analyses indicated that while there was a significant interactive effect of father-reported and adolescent-reported father-adolescent communication in Chinese two-parent families, no significant interaction was found for mother-adolescent dyad. Besides, adolescent-reported mother-child communication interacted with mother-reported communication in Chinese single-mother families only. The findings clarify parent-adolescent discrepancies in parent-child communication in different types of families in China and they have theoretical and practical implications on the role of discrepancies in parents and adolescent children on perceived parent-adolescent communication in early adolescent depressive symptoms.
Intramuscular Exposure to a Lethal Dose of Ricin Toxin Leads to Endothelial Glycocalyx Shedding and Microvascular Flow Abnormality in Mice and Swine
Authors: Sapoznikov Anita , Gal Yoav , Evgy Yentl , Aftalion Moshe , Katalan Shahaf , Sabo Tamar , Kronman Chanoch , Falach Reut
Published: November 2021

Ricin toxin isolated from the castor bean (Ricinus communis) is one of the most potent and lethal molecules known. While the pathophysiology and clinical consequences of ricin poisoning by the parenteral route, i.e., intramuscular penetration, have been described recently in various animal models, the preceding mechanism underlying the clinical manifestations of systemic ricin poisoning has not been completely defined. Here, we show that following intramuscular administration, ricin bound preferentially to the vasculature in both mice and swine, leading to coagulopathy and widespread hemorrhages. Increased levels of circulating VEGF and decreased expression of vascular VE-cadherin caused blood vessel impairment, thereby promoting hyperpermeability in various organs. Elevated levels of soluble heparan sulfate, hyaluronic acid and syndecan-1 were measured in blood samples following ricin intoxication, indicating that the vascular glycocalyx of both mice and swine underwent extensive damage. Finally, by using side-stream dark field intravital microscopy imaging, we determined that ricin poisoning leads to microvasculature malfunctioning, as manifested by aberrant blood flow and a significant decrease in the number of diffused microvessels. These findings, which suggest that glycocalyx shedding and microcirculation dysfunction play a major role in the pathology of systemic ricin poisoning, may serve for the formulation of specifically tailored therapies for treating parenteral ricin intoxication.
Measurement of Lateral Transmission of Force in the Extensor Digitorum Longus Muscle of Young and Old Mice
Authors: Minato Keitaro , Yoshimoto Yuki , Kurosawa Tamaki , Watanabe Kei , Kawashima Hiroyuki , Ikemoto-Uezumi Madoka , Uezumi Akiyoshi
Published: November 2021

The main function of skeletal muscles is to generate force. The force developed by myofiber contraction is transmitted to the tendon. There are two pathways of force transmission from myofibers to tendons: longitudinal transmission that depends on tension elicited via the myotendinous junction and lateral transmission that depends on shear elicited via the interface between the myofiber surface and surrounding connective tissue. Experiments using animal muscle and mathematical models indicated that lateral transmission is the dominant pathway in muscle force transmission. Studies using rat muscle showed that the efficiency of lateral force transmission declines with age. Here, the lateral transmission of force was measured using the extensor digitorum longus muscle from young and old mice. Dependence on longitudinal transmission increased in the old muscle, and there was a trend for lower efficiency of lateral force transmission in the old muscle compared to the young muscle. There was a noticeable increase in the connective tissue volume in the old muscle; however, there was no significant change in the expression of dystrophin, a critical molecule for the link between the myofiber cytoskeleton and extracellular matrix. This study demonstrates the measurement of lateral force transmission in mouse muscles and that alteration in force transmission property may underlie age-related muscle weakness.
Thermodynamic Studies of Interactions between Sertraline Hydrochloride and Randomly Methylated β-Cyclodextrin Molecules Supported by Circular Dichroism Spectroscopy and Molecular Docking Results
Authors: Belica-Pacha Sylwia , Daśko Mateusz , Buko Vyacheslav , Zavodnik Ilya , Miłowska Katarzyna , Bryszewska Maria
Published: November 2021

The interaction between sertraline hydrochloride (SRT) and randomly methylated β-cyclodextrin (RMβCD) molecules have been investigated at 298.15 K under atmospheric pressure. The method used—Isothermal Titration Calorimetry (ITC) enabled to determine values of the thermodynamic functions like the enthalpy (ΔH), the entropy (ΔS) and the Gibbs free energy (ΔG) of binding for the examined system. Moreover, the stoichiometry coefficient of binding (n) and binding/association constant (K) value have been calculated from the experimental results. The obtained outcome was compared with the data from the literature for other non-ionic βCD derivatives interacting with SRT and the enthalpy-entropy compensation were observed and interpreted. Furthermore, the connection of RMβCD with SRT was characterized by circular dichroism spectroscopy (CD) and complexes of βCD derivatives with SRT were characterized through the computational studies with the use of molecular docking (MD).
Identification of Potential Long Non-Coding RNA Candidates that Contribute to Triple-Negative Breast Cancer in Humans through Computational Approach
Authors: Rahman Md. Motiar , Hossain Md. Tofazzal , Reza Md. Selim , Peng Yin , Feng Shengzhong , Wei Yanjie
Published: November 2021

Breast cancer (BC) is the most frequent malignancy identified in adult females, resulting in enormous financial losses worldwide. Owing to the heterogeneity as well as various molecular subtypes, the molecular pathways underlying carcinogenesis in various forms of BC are distinct. Therefore, the advancement of alternative therapy is required to combat the ailment. Recent analyses propose that long non-coding RNAs (lncRNAs) perform an essential function in controlling immune response, and therefore, may provide essential information about the disorder. However, their function in patients with triple-negative BC (TNBC) has not been explored in detail. Here, we analyzed the changes in the genomic expression of messenger RNA (mRNA) and lncRNA in standard control in response to cancer metastasis using publicly available single-cell RNA-Seq data. We identified a total of 197 potentially novel lncRNAs in TNBC patients of which 86 were differentially upregulated and 111 were differentially downregulated. In addition, among the 909 candidate lncRNA transcripts, 19 were significantly differentially expressed (DE) of which three were upregulated and 16 were downregulated. On the other hand, 1901 mRNA transcripts were significantly DE of which 1110 were upregulated and 791 were downregulated by TNBCs subtypes. The Gene Ontology (GO) analyses showed that some of the host genes were enriched in various biological, molecular, and cellular functions. The Kyoto encyclopedia of genes and genomes (KEGG) pathway analysis showed that some of the genes were involved in only one pathway of prostate cancer. The lncRNA-miRNA-gene network analysis showed that the lncRNAs TCONS_00076394 and TCONS_00051377 interacted with breast cancer-related micro RNAs (miRNAs) and the host genes of these lncRNAs were also functionally related to breast cancer. Thus, this study provides novel lncRNAs as potential biomarkers for the therapeutic intervention of this cancer subtype.
Nanotechnology for Topical Drug Delivery to the Anterior Segment of the Eye
Authors: Vaneev Alexander , Tikhomirova Victoria , Chesnokova Natalia , Popova Ekaterina , Beznos Olga , Kost Olga , Klyachko Natalia
Published: November 2021

Topical drug delivery is one of the most challenging aspects of eye therapy. Eye drops are the most prevalent drug form, especially for widely distributed anterior segment eye diseases (cataracts, glaucoma, dry eye syndrome, inflammatory diseases, etc.), because they are convenient and easy to apply by patients. However, conventional drug formulations are usually characterized by short retention time in the tear film, insufficient contact with epithelium, fast elimination, and difficulties in overcoming ocular tissue barriers. Not more than 5% of the total drug dose administered in eye drops reaches the interior ocular tissues. To overcome the ocular drug delivery barriers and improve drug bioavailability, various conventional and novel drug delivery systems have been developed. Among these, nanosize carriers are the most attractive. The review is focused on the different drug carriers, such as synthetic and natural polymers, as well as inorganic carriers, with special attention to nanoparticles and nanomicelles. Studies in vitro and in vivo have demonstrated that new formulations could help to improve the bioavailability of the drugs, provide sustained drug release, enhance and prolong their therapeutic action. Promising results were obtained with drug-loaded nanoparticles included in in situ gel.
Severity Assessment and Progression Prediction of COVID-19 Patients Based on the LesionEncoder Framework and Chest CT
Authors: Feng You-Zhen , Liu Sidong , Cheng Zhong-Yuan , Quiroz Juan C. , Rezazadegan Dana , Chen Ping-Kang , Lin Qi-Ting , Qian Long , Liu Xiao-Fang , Berkovsky Shlomo , Coiera Enrico , Song Lei , Qiu Xiao-Ming , Cai Xiang-Ran
Published: November 2021

Automatic severity assessment and progression prediction can facilitate admission, triage, and referral of COVID-19 patients. This study aims to explore the potential use of lung lesion features in the management of COVID-19, based on the assumption that lesion features may carry important diagnostic and prognostic information for quantifying infection severity and forecasting disease progression. A novel LesionEncoder framework is proposed to detect lesions in chest CT scans and to encode lesion features for automatic severity assessment and progression prediction. The LesionEncoder framework consists of a U-Net module for detecting lesions and extracting features from individual CT slices, and a recurrent neural network (RNN) module for learning the relationship between feature vectors and collectively classifying the sequence of feature vectors. Chest CT scans of two cohorts of COVID-19 patients from two hospitals in China were used for training and testing the proposed framework. When applied to assessing severity, this framework outperformed baseline methods achieving a sensitivity of 0.818, specificity of 0.952, accuracy of 0.940, and AUC of 0.903. It also outperformed the other tested methods in disease progression prediction with a sensitivity of 0.667, specificity of 0.838, accuracy of 0.829, and AUC of 0.736. The LesionEncoder framework demonstrates a strong potential for clinical application in current COVID-19 management, particularly in automatic severity assessment of COVID-19 patients. This framework also has a potential for other lesion-focused medical image analyses.
Efficacy of the Applied Natural Enemies on the Survival of Colorado Potato Beetle Adults
Authors: Půža Vladimír , Nermuť Jiří , Konopická Jana , Skoková Habuštová Oxana
Published: November 2021

Colorado potato beetle Leptinotarsa decemlineata is among the most destructive pests of potatoes quickly developing resistance to traditional insecticides. In the present study, we tested the effect of various species and strains of entomopathogenic nematodes on CPB adults, and subsequently, the most effective nematodes were applied alone and in combination with entomopathogenic fungus B. bassiana in pots with potato plants and in the field and their effect on the number of emerging adults was evaluated. In the experimental infections, both the nematode invasion and pathogenicity were variable, and, in several strains, the mortality reached 100%. In pot experiments, soil application of nematodes S. carpocapsae 1343 and S. feltiae Jakub and fungus significantly decreased numbers of emerging CPB adults, while, after the application on leaves, only fungal treatment was effective. The field application of fungus B. bassiana significantly decreased the number of emerging CPB adults in comparison to control sites by ca. 30% while the effect of nematodes and the nematodes–fungus combination was not significant. In conclusion, we demonstrate the necessity of thorough bioassays to select the most effective nematode strains. Entomopathogenic nematodes have the potential to effectively decrease the emergence of CPB adults, but further research is needed to improve the effectiveness in the field.
What Could Arrest an Eriophyoid Mite on a Plant? The Case of Aculops allotrichus from the Black Locust Tree
Authors: Michalska Katarzyna , Studnicki Marcin
Published: November 2021

Aculops allotrichus is a vagrant eriophyoid that lives gregariously on the leaves of the black locust tree. This study demonstrated that conspecifics can have a significant impact on A. allotrichus females on unprofitable, old black locust leaves and can arrest them on those leaves. The effect was more pronounced in females that were exposed to artificially injured individuals than to intact ones. They not only prolonged their sojourn on leaf discs with pierced conspecifics, but also preferred the leaf disc halves with damaged individuals to clean ones. Aculops allotrichus is the first described herbivore in which artificially injured conspecifics, instead of causing alarm, keep the foraging individuals within a risky patch. Other objects, such as artificially injured or intact heterospecifics, pollen or sand, were irrelevant to the eriophyoid females on old leaf patches. In tests with old leaves of maple, magnolia and hard kiwi vine, the females postponed their movement from non-host leaf discs, which suggests that they may need more time to recognise and evaluate unfamiliar plants than familiar ones.
The Need for Expanding Pulmonary Rehabilitation Services
Authors: Lahham Aroub , Holland Anne E.
Published: November 2021

Pulmonary rehabilitation is a strongly recommended and effective treatment for people with chronic lung disease. However, access to pulmonary rehabilitation is poor. Globally, pulmonary rehabilitation is accessed by less than 3% of people with chronic lung disease. Barriers to referral, uptake and completion of pulmonary rehabilitation are well documented and linked with organizational, practitioner and patient-related factors. Enhancing the knowledge of health care professionals, family carers, and people with chronic lung disease about the program and its benefits produces modest increases in referral and uptake rates, but evidence of the sustainability of such approaches is limited. Additionally, initiatives focusing on addressing organizational barriers to access, such as expanding services and implementing alternative models to the conventional center-based setting, are not yet widely used in clinical practice. The COVID-19 pandemic has highlighted the urgent need for health care systems to deliver pulmonary rehabilitation programs remotely, safely, and efficiently. This paper will discuss the pressing need to address the issue of the low accessibility of pulmonary rehabilitation. It will also highlight the distinctive challenges to pulmonary rehabilitation delivery in rural and remote regions, as well as low-income countries.
Mechanical and Microstructural Characterization of Quarry Rock Dust Incorporated Steel Fiber Reinforced Geopolymer Concrete and Residual Properties after Exposure to Elevated Temperatures
Authors: Ibraheem Muhammad , Butt Faheem , Waqas Rana Muhammad , Hussain Khadim , Tufail Rana Faisal , Ahmad Naveed , Usanova Ksenia , Musarat Muhammad Ali
Published: November 2021

The purpose of this research is to study the effects of quarry rock dust (QRD) and steel fibers (SF) inclusion on the fresh, mechanical, and microstructural properties of fly ash (FA) and ground granulated blast furnace slag (SG)-based geopolymer concrete (GPC) exposed to elevated temperatures. Such types of ternary mixes were prepared by blending waste materials from different industries, including QRD, SG, and FA, with alkaline activator solutions. The multiphysical models show that the inclusion of steel fibers and binders can enhance the mechanical properties of GPC. In this study, a total of 18 different mix proportions were designed with different proportions of QRD (0%, 5%, 10%, 15%, and 20%) and steel fibers (0.75% and 1.5%). The slag was replaced by different proportions of QRD in fly ash, and SG-based GPC mixes to study the effect of QRD incorporation. The mechanical properties of specimens, i.e., compressive strength, splitting tensile strength, and flexural strength, were determined by testing cubes, cylinders, and prisms, respectively, at different ages (7, 28, and 56 days). The specimens were also heated up to 800 °C to evaluate the resistance of specimens to elevated temperature in terms of residual compressive strength and weight loss. The test results showed that the mechanical strength of GPC mixes (without steel fibers) increased by 6–11%, with an increase in QRD content up to 15% at the age of 28 days. In contrast, more than 15% of QRD contents resulted in decreasing the mechanical strength properties. Incorporating steel fibers in a fraction of 0.75% by volume increased the compressive, tensile, and flexural strength of GPC mixes by 15%, 23%, and 34%, respectively. However, further addition of steel fibers at 1.5% by volume lowered the mechanical strength properties. The optimal mixture of QRD incorporated FA-SG-based GPC (QFS-GPC) was observed with 15% QRD and 0.75% steel fibers contents considering the performance in workability and mechanical properties. The results also showed that under elevated temperatures up to 800 °C, the weight loss of QFS-GPC specimens persistently increased with a consistent decrease in the residual compressive strength for increasing QRD content and temperature. Furthermore, the microstructure characterization of QRD blended GPC mixes were also carried out by performing scanning electron microscopy (SEM), X-ray diffraction (XRD), and energy dispersive spectroscopy (EDS).
Synthesis and Characterization of Activated Carbon Co-Mixed Electrospun Titanium Oxide Nanofibers as Flow Electrode in Capacitive Deionization
Authors: Folaranmi Gbenro , Tauk Myriam , Bechelany Mikhael , Sistat Philippe , Cretin Marc , Zaviska Francois
Published: November 2021

Flow capacitive deionization is a water desalination technique that uses liquid carbon-based electrodes to recover fresh water from brackish or seawater. This is a potential second-generation water desalination process, however it is limited by parameters such as feed electrode conductivity, interfacial resistance, viscosity, and so on. In this study, titanium oxide nanofibers (TiO2NF) were manufactured using an electrospinning process and then blended with commercial activated carbon (AC) to create a well distributed flow electrode in this study. Field emission scanning electron microscope (FESEM), X-ray diffraction (XRD), Raman spectroscopy, X-ray photoelectron spectroscopy (XPS), and energy dispersive X-ray (EDX) were used to characterize the morphology, crystal structure, and chemical moieties of the as-synthesized composites. Notably, the flow electrode containing 1 wt.% TiO2NF (ACTiO2NF 1 wt.%) had the highest capacitance and the best salt removal rate (0.033 mg/min·cm2) of all the composites. The improvement in cell performance at this ratio indicates that the nanofibers are uniformly distributed over the electrode’s surface, preventing electrode passivation, and nanofiber agglomeration, which could impede ion flow to the electrode’s pores. This research suggests that the physical mixture could be used as a flow electrode in capacitive deionization.
Correlation between Cutting Clearance, Deformation Texture, and Magnetic Loss Prediction in Non-Oriented Electrical Steels
Authors: Füzer Ján , Dobák Samuel , Petryshynets Ivan , Kollár Peter , Kováč František , Slota Ján
Published: November 2021

Manufacturing the magnetic cores in electrical machines impacts the magnetic performance of the electrical steel by inducing stresses near the cutting edge. In this paper, energy loss behaviour in non-oriented electrical steels punched with different cutting clearances before and after annealing is investigated. An experimental shear cutting tool was employed to punch the ring-shaped parts from electrical steels in a finished state with four different values of cutting clearance corresponding to 1%, 3%, 5%, and 7% of the sheet thickness. The effect of cutting clearance on the magnetic losses is derived and analysed by the statistical theory of losses and associated loss separation concept including the analysis of movable magnetic objects. In this framework, this paper assesses the combined effect of cutting clearance, frequency, and heat treatment on the hysteresis loops and iron losses in non-oriented FeSi electrical steels. Measurements have been performed from quasi-static to 400 Hz at peak induction Bp = 1.0 T. Both states before and after heat treatment have been considered. The excess loss is observed as the most sensitive loss component to cutting clearance and its magneto–structural correlation is quantified.
Dynamic Behavior of Aviation Polymer Composites at Various Weight Fractions of Physical Modifier
Authors: Kosicka Ewelina , Borowiec Marek , Kowalczuk Marcin , Krzyzak Aneta
Published: November 2021

The aim of this study was to determine the effect of a selected physical modifier with different granularity and mass percentage on the dynamics of aerospace polymer composites. The tests were carried out on samples made of certified aerospace materials used, among other purposes, for the manufacture of aircraft skin components. The hybrid composites were prepared from L285 resin, H286 hardener, GG 280T carbon fabric in twill 2/2 and alumina (Al2O3, designated as EA in this work). The manufactured composites contained alumina with grain sizes of F220, F240, F280, F320 and F360. The mass proportion of the modifier in the tested samples was 5% and 15%. The tested specimens, as cantilever beams fixed unilaterally, were subjected to kinematic excitation with defined parameters of amplitude and frequency excitation in the basic resonance zone of the structure. The results, obtained as dynamic responses, are presented in the form of amplitude–frequency characteristics. These relationships clearly indicate the variable nature of composite materials due to modifier density and grain size. The novelty of this study is the investigation of the influence of the alumina properties on system dynamics responses.
Identifying Chemical Composition, Safety and Bioactivity of Thai Rice Grass Extract Drink in Cells and Animals
Authors: Phimphilai Suthaya , Koonyosying Pimpisid , Hutachok Nuntouchaporn , Kampoun Tanyaluk , Daw Rufus , Chaiyasut Chaiyavat , Prasartthong-osoth Vanli , Srichairatanakool Somdet
Published: November 2021

Rice grass has been reported to contain bioactive compounds that possess antioxidant and free-radical scavenging activities. We aimed to assess rice grass extract (RGE) drink by determining catechin content, free-radical scavenging and iron-binding properties, as well as toxicity in cells and animals. Young rice grass (Sukhothai-1 strain) was dried, extracted with hot water and lyophilized in a vacuum chamber. The resulting extract was reconstituted with deionized water (260 mg/40 mL) and served as Sukhothai-1 rice grass extract drink (ST1-RGE). HPLC results revealed at least eight phenolic compounds, for which the major catechins were catechin, epicatechin and epigallocatechin-3-gallate (EGCG) (2.71–3.57, 0.98–1.85 and 25.47–27.55 mg/40 mL serving, respectively). Elements (As, Cu, Pb, Sn and Zn) and aflatoxin (B1, B2, G1 and G2) contents did not exceed the relevant limits when compared with WHO guideline values. Importantly, ST1-RGE drink exerted radical-scavenging, iron-chelating and anti-lipid peroxidation properties in aqueous and biological environments in a concentration-dependent manner. The drink was not toxic to cells and animals. Thus, Sukhothai-1 rice grass product is an edible drink that is rich in catechins, particularly EGCG, and exhibited antioxidant, free radical scavenging and iron-binding/chelating properties. The product represents a functional drink that is capable of alleviating conditions of oxidative stress and iron overload.
Age-Related Differences in Body Fatness and Nutritional Status in Large Sample of Serbian Women 20–70 Years of Age
Authors: Dopsaj Milivoj , Kukić Filip , Maksimović Miloš , Glavač Boris , Radovanović Dragan , Đorđević-Nikić Marina
Published: November 2021

Obesity due to increased body fatness has been recognized internationally as one of the leading factors affecting individual and public health. The aim of this study was to determine age-related differences in body fatness in a representative sample of women in Serbia. The study included 1937 Serbian females aged 20 to 69.9 years from all regions of the Republic of Serbia. The obesity and body fatness were analyzed using body mass index (BMI), body fat mass (BFM), percent of body fat (PBF), body fat mass index (BFMI), and visceral fat area (VFA). Multivariate analysis of variance with post hoc pairwise comparisons revealed the largest differences between the age categories in VFA followed by BFMI, PBF, and BMI. The prevalence of overweight, obese, and extremely obese subjects in the overall sample by BMI was 30.77, 1.32, and 1.40%, respectively. The prevalence was higher when calculated by PBF, with 37.84 and 20.11% for overweight and obese subjects. The prevalence of overweight and obesity, as calculated by BMI and PBF, was higher in older age groups of Serbian women. The prevalence of overweight women in the oldest group was 4.32 times higher, while the rate of obesity was 8.67 times higher than in the youngest group. Our results are a good basis for planning and implementing preventive health activities and monitoring changes in morphological parameters in Serbian women of different ages.
Trends in Childhood Poison Exposures and Fatalities: A Retrospective Secondary Data Analysis of the 2009–2019 U.S. National Poison Data System Annual Reports
Authors: Li Hong , Dodd-Butera Teresa , Beaman Margaret L. , Pritty Molly Broderick , Heitritter Thomas E. , Clark Richard F.
Published: November 2021

Despite significant prevention efforts, childhood poison exposures remain a serious public health challenge in the United States. This study aimed to assess annual trends of pharmaceutical vs. non-pharmaceutical poison exposures in the US among children 0–19 years and compare the odds of death by children’s age group. Poison exposure and fatality data were retrospectively extracted from 2009 to 2019 National Poison Data System (NPDS) annual reports for children in all reported age groups. Overall, there was a significant reduction in the annual population-adjusted poison exposures in children (annual percentage change = −2.54%, 95% CI = −3.94% to −1.15%, p < 0.01), but not in poisoning-related fatalities. Children 0–5 had similar odds of dying from exposure to non-pharmaceuticals vs. pharmaceuticals. The odds of children 6–12 dying from non-pharmaceuticals vs. pharmaceuticals was 2.38 (95% CI = 1.58, 3.58), χ2 = 18.53, p < 0.001. In contrast, the odds of children 13–19 dying from pharmaceuticals vs. non-pharmaceuticals was 3.04 (95% CI = 2.51, 3.69), χ2 = 141.16, p < 0.001. Suicidal intent accounted for 40.63% of pharmaceutical deaths in children 6–12, as well as 48.66% of pharmaceutical and 31.15% of non-pharmaceutical deaths in children 13–19. While a significant decline in overall childhood poison exposures was reported, a decrease in poisoning-related fatalities was not observed. Children in different age groups had contrasting relative odds of death from pharmaceutical and non-pharmaceutical exposures. Among older children, a greater proportion of poisoning-related deaths was due to intentional suicide. These findings provide evidence of age-specific trends in childhood poison exposure risk and directions for future poison prevention efforts and behavioral health partnerships.
Preparation of Komagataeibacter xylinus Inoculum for Bacterial Cellulose Biosynthesis Using Magnetically Assisted External-Loop Airlift Bioreactor
Authors: Żywicka Anna , Ciecholewska-Juśko Daria , Drozd Radosław , Rakoczy Rafał , Konopacki Maciej , Kordas Marian , Junka Adam , Migdał Paweł , Fijałkowski Karol
Published: November 2021

The aim of this study was to demonstrate the applicability of a novel magnetically assisted external-loop airlift bioreactor (EL-ALB), equipped with rotating magnetic field (RMF) generators for the preparation of Komagataeibacterxylinus inoculum during three-cycle repeated fed-batch cultures, further used for bacterial cellulose (BC) production. The fermentation carried out in the RMF-assisted EL-ALB allowed to obtain an inoculum of more than 200× higher cellular density compared to classical methods of inoculum preparation. The inoculum obtained in the RMF-assisted EL-ALB was characterized by a high and stable metabolic activity during repeated batch fermentation process. The application of the RMF-assisted EL-ALB for K. xylinus inoculum production did not induce the formation of cellulose-deficient mutants. It was also confirmed that the ability of K. xylinus to produce BC was at the same level (7.26 g/L of dry mass), regardless of inoculum age. Additionally, the BC obtained from the inoculum produced in the RMF-assisted EL-ALB was characterized by reproducible water-related properties, mechanical strength, nano-fibrillar structure and total crystallinity index. The lack of any negative impact of inoculum preparation method using RMF-assisted EL-ALB on BC properties is of paramount value for its future applications, including use as a biomaterial in tissue engineering, wound healing, and drug delivery, where especially BC liquid capacity, nanostructure, crystallinity, and mechanical properties play essential roles.
They Are Preserved Forever: Visualising the Memorialisation of Archipelagic Religious and Community Identities
Authors: Moore James , Gibbon Sarah Jane
Published: November 2021

In this article, we respond to the Special Issue theme by addressing the complexities of religious identities in archipelagic communities where the dual role of the sea as conduit and barrier has impacted the parish system, farming estates and community life. The focus is primarily on nineteenth and twentieth century testimonies and material evidence, approached within a broader chronological context going back to the Middle Ages. Using qualitative GIS mapping of the habitations of the people memorialised in two burial grounds in Orkney, we visualise the active role of the islander in constructing identities linking people and place at parish, community and personal levels. The results show that the people with memorial stones were buried within a long-established parochial structure but did not adhere to ecclesiastical norms, with district burial grounds being favoured over a single parish churchyard. We conclude that this approach demonstrates the complexities of identities within an island community and identify its applicability in other contexts combining material culture and historical documentation to investigate religious island identities.
Automatic Optical Measurement and Control of Benzene and Benzenoids in Natural Gas Pipelines
Authors: Galassi Rossana , Contini Christian , Pucci Matteo , Gambi Ennio
Published: November 2021

The presence of benzene and similar aromatic compounds in civil environments is due to anthropic actions but also to natural sources. Natural gas consists of a gas mixture where benzene and related compounds are usually presents. Thus, the detection of these compounds in natural gas pipelines is of the utmost importance as well as the control of the concentration level, which must remain below the limits consented by law. In this regard, it is of striking interest to engineer devices able to detect these compounds by automatic and continuous remote control. Here, we discuss the application of an optical device designed for the measurement of sulfured odorizing agents in natural gas pipelines aiming at the detection and the measurement of benzene, toluene, and xylenes (BTX) in the same contexts. The instrument consists of a customized UV spectrophotometer connected to an automatic control system able to provide in-field detections of BTX through a continuous and remote check of the gaseous mixture. Relatively to benzene, the instrument is characterized by values of LOD (level of detection) and LOQ (level of quantification) equal to 0.55 and 1.84 mg/Sm3, respectively. Similar limits are found for toluene and xylenes (LOD of 0.81, 1.05, 1.41, and 1.00 mg/Sm3 for toluene, meta-, ortho-, and para-xylene, respectively).
Micromechanical Force Sensor Using the Stress–Impedance Effect of Soft Magnetic FeCuNbSiB
Authors: Froemel Joerg , Diguet Gildas , Muroyama Masanori
Published: November 2021

By using the stress–impedance (SI) effect of a soft magnetic amorphous FeCuNbSiB alloy, a micromachined force sensor was fabricated and characterized. The alloy was used as a sputtered thin film of 500 nm thickness. To clarify the SI effect in the used material as a thin film, its magnetic and mechanical properties were first investigated. The stress dependence of the magnetic permeability was shown to be caused by the used transducer effect. The sputtered thin film also exhibited a large yield strength of 983 GPa. Even though the fabrication technology for the device is very simple, characterization revealed a gauge factor (GF) of 756, which is several times larger than that achieved with conventional transducer effects, such as the piezoresistive effect. The fabricated device shows great application potential as a tactile sensor.
An Information-Theoretic Approach to Detect the Associations of GPS-Tracked Heifers in Pasture
Authors: Meckbach Cornelia , Elsholz Sabrina , Siede Caroline , Traulsen Imke
Published: November 2021

Sensor technologies, such as the Global Navigation Satellite System (GNSS), produce huge amounts of data by tracking animal locations with high temporal resolution. Due to this high resolution, all animals show at least some co-occurrences, and the pure presence or absence of co-occurrences is not satisfactory for social network construction. Further, tracked animal contacts contain noise due to measurement errors or random co-occurrences. To identify significant associations, null models are commonly used, but the determination of an appropriate null model for GNSS data by maintaining the autocorrelation of tracks is challenging, and the construction is time and memory consuming. Bioinformaticians encounter phylogenetic background and random noise on sequencing data. They estimate this noise directly on the data by using the average product correction procedure, a method applied to information-theoretic measures. Using Global Positioning System (GPS) data of heifers in a pasture, we performed a proof of concept that this approach can be transferred to animal science for social network construction. The approach outputs stable results for up to 30% missing data points, and the predicted associations were in line with those of the null models. The effect of different distance thresholds for contact definition was marginal, but animal activity strongly affected the network structure.
An Intelligent Multimode Clustering Mechanism Using Driving Pattern Recognition in Cognitive Internet of Vehicles
Authors: Chang Huigang , Ning Nianwen
Published: November 2021

Connected autonomous vehicles can leverage communication and artificial intelligence technologies to effectively overcome the perceived limitations of individuals and enhance driving safety and stability. However, due to the high dynamics of the vehicular network and frequent interruptions and handovers, it is still challenging to provide stable communication connections between vehicles, which is likely to cause disasters. To address this issue, in this paper, we propose an intelligent clustering mechanism based on driving patterns in heterogeneous Cognitive Internet of Vehicles (CIoVs). In the proposed approach, we analyze the driving mode containing multiple feature parameters to accurately capture the driving characteristics. To ensure the accuracy of pattern recognition, a genetic algorithm-based neural network pattern recognition algorithm is proposed to support the reliable clustering of connected autonomous vehicles. The cognitive engines recognize the driving modes to group vehicles with a similar driving mode into a relatively stable cluster. In addition, we formulate the stability and survival time of clusters and analyze the communication performance of the clustering mechanism. Simulation results show that the proposed mechanism improves the reliable communication throughput and average cluster lifetime by approximately 14.4% and 11.5% respectively compared to the state-of-the-art approaches.
Social Innovation, Employee Value Cocreation, and Organizational Citizenship Behavior in a Sport-Related Social Enterprise: Mediating Effect of Corporate Social Responsibility
Authors: Chen Chen-Yueh , Chou Ya-Lun , Lee Chun-Shih
Published: November 2021

This stakeholder theory-based study explored the mediating role of employee attitudes regarding corporate social responsibility (CSR) among perceptions of social innovation (SI), value cocreation (VCC), and organizational citizenship behavior (OCB) in a sport social enterprise context. Eighty-three employees in a Taiwanese social enterprise were recruited using random sampling. A self-administered online survey was conducted for the collection of data, which were examined using linear regression analysis. The results indicated that employee attitudes regarding CSR fully mediated the relationship among perceived SI and OCB. Additionally, the attitude toward CSR was found to partially mediate the relationship between perceptions of SI and VCC. Employees’ attitudes toward CSR play a critical role in increasing their VCC and OCB in addition to their perception of an organization’s SI. Meaningful theoretical and practical implications were revealed.
Distribution, Formation and Human Health Risk of Fluorine in Groundwater in Songnen Plain, NE China
Authors: Wang Jianwei , Zheng Nengzhan , Liu Hong , Cao Xinyi , Teng Yanguo , Zhai Yuanzheng
Published: November 2021

Songnen Plain is one of the three great plains in northeast China with abundant groundwater resources. The continuous population growth and the rapid development of agriculture and economy in China has caused a series of environmental problems in the plain, such as endemic diseases caused by the accumulation of harmful substances in drinking water. This paper conducts a systematic investigation of fluorine in the groundwater of Songnen Plain. The results showed that fluorine was widespread in the groundwater of the plain in the concentration range of BDL–8.54 mg·L−1, at a mean value of 0.63 mg·L−1 and detectable at a rate of 85.91%. The highest concentrations of fluorine were found in central and southwest areas of the plain. The concentration exceeded the guideline values for fluorine in drinking water and may have varying degrees of adverse effects on adults, and especially children, in the study area. The fluorine in groundwater mainly came from the dissolution of fluorite and other fluorine-containing minerals, and the concentrations and distribution of fluorine were affected by cation exchange, groundwater flow field and hydrochemical indexes (pH, TDS and HCO3−). The study provides scientific basis for the investigation, evaluation and prevention of endemic diseases caused by fluorine.
Multistage and Dynamic Layout Optimization for Electric Vehicle Charging Stations Based on the Behavior Analysis of Travelers
Authors: Chen Feng , Feng Minling , Han Bing , Lu Shaofeng
Published: November 2021

Electric vehicles (EV) are growing fast in recent years with the widespread concern about carbon neutrality. The development of charging infrastructures needs to be in phase with EV both in terms of quantity and charging time to decrease the range anxiety of EV users and resource waste. This paper proposed a multistage and dynamic layout optimization model based on mixed integer linear programming (MILP) for EV charging stations (CSs) to minimize the total social costs (TSC) consisting of the detour cost of EV users and the construction, relocation, and operating cost of CSs. The charging satisfaction coefficient and M/M/S/K model of queuing theory has been introduced to determine the desirable charging supply. The spatial-temporal distribution of charging demand was modeled based on the behavior analysis of travelers and over the discrete-time intervals for a day. Comparison studies based on the Sioux Falls network reveal that TSC with a multistage optimization strategy will drop 8.79% from that with a one-time optimization strategy. Charging service quality, relocation cost, and road network scales have a significant impact on the optimization results according to the sensitivity analysis.