bluuebunny/crossref_metadata_2025 huggingface dataset:
Lifestyle Factors and Breast Cancer in Females with PTEN Hamartoma Tumor Syndrome (PHTS)
Authors: Hendricks Linda A. J. , Verbeek Katja C. J. , Schuurs-Hoeijmakers Janneke H. M. , Mensenkamp Arjen R. , Brems Hilde , de Putter Robin , Anastasiadou Violetta C. , Villy Marie-Charlotte , Jahn Arne , Steinke-Lange Verena , Baldassarri Margherita , Irmejs Arvids , de Jong Mirjam M. , Links Thera P. , Leter Edward M. , Bosch Daniëlle G. M. , Høberg-Vetti Hildegunn , Tveit Haavind Marianne , Jørgensen Kjersti , Mæhle Lovise , Blatnik Ana , Brunet Joan , Darder Esther , Tham Emma , Hoogerbrugge Nicoline , Vos Janet R.
Published: February 2024

Females with PTEN Hamartoma Tumor Syndrome (PHTS) have breast cancer risks up to 76%. This study assessed associations between breast cancer and lifestyle in European female adult PHTS patients. Data were collected via patient questionnaires (July 2020–March 2023) and genetic diagnoses from medical files. Associations between lifestyle and breast cancer were calculated using logistic regression corrected for age. Index patients with breast cancer before PHTS diagnosis (breast cancer index) were excluded for ascertainment bias correction. In total, 125 patients were included who completed the questionnaire at a mean age of 44 years (SD = 13). This included 21 breast cancer indexes (17%) and 39 females who developed breast cancer at 43 years (SD = 9). Breast cancer patients performed about 1.1 times less often 0–1 times/week physical activity than ≥2 times (ORtotal-adj = 0.9 (95%CI 0.3–2.6); consumed daily about 1.2–1.8 times more often ≥1 than 0–1 glasses of alcohol (ORtotal-adj = 1.2 (95%CI 0.4–4.0); ORnon-breastcancer-index-adj = 1.8 (95%CI 0.4–6.9); were about 1.04–1.3 times more often smokers than non-smokers (ORtotal-adj = 1.04 (95%CI 0.4–2.8); ORnon-breastcancer-index-adj = 1.3 (95%CI 0.4–4.2)); and overweight or obesity (72%) was about 1.02–1.3 times less common (ORtotal-adj = 0.98 (95%CI 0.4–2.6); ORnon-breastcancer-index-adj = 0.8 (95%CI 0.3–2.7)). Similar associations between lifestyle and breast cancer are suggested for PHTS and the general population. Despite not being statistically significant, results are clinically relevant and suggest that awareness of the effects of lifestyle on patients’ breast cancer risk is important.
Correction: Srinivasan Rajsri et al. Acute Myeloid Leukemia Stem Cells in Minimal/Measurable Residual Disease Detection. Cancers 2023, 15, 2866
Authors: Srinivasan Rajsri Kritika , Roy Nainita , Chakraborty Sohini
Published: February 2024

In the original publication [...]
miRNA on the Battlefield of Cancer: Significance in Cancer Stem Cells, WNT Pathway, and Treatment
Authors: Bhagtaney Lekha , Dharmarajan Arun , Warrier Sudha
Published: February 2024

Carcinogenesis is a complex process characterized by intricate changes in organ histology, biochemistry, epigenetics, and genetics. Within this intricate landscape, cancer stem cells (CSCs) have emerged as distinct cell types possessing unique attributes that significantly contribute to the pathogenesis of cancer. The WNT signaling pathway plays a critical role in maintaining somatic stem cell pluripotency. However, in cancer, overexpression of WNT mediators enhances the activity of β-catenin, resulting in phenomena such as recurrence and unfavorable survival outcomes. Notably, CSCs exhibit heightened WNT signaling compared to bulk cancer cells, providing intriguing insights into their functional characteristics. MicroRNAs (miRNAs), as post-transcriptional gene expression regulators, modulate various physiological processes in numerous diseases including cancer. Upregulation or downregulation of miRNAs can affect the production of pro-oncogenic or anti-oncogenic proteins, influencing cellular processes that maintain tissue homeostasis and promote either apoptosis or differentiation, even in cancer cells. In order to understand the dysregulation of miRNAs, it is essential to examine miRNA biogenesis and any possible alterations at each step. The potential of a miRNA as a biomarker in prognosis, diagnosis, and detection is being assessed using technologies such as next-generation sequencing. Extensive research has explored miRNA expression profiles in cancer, leading to their utilization as diagnostic tools and the development of personalized and targeted cancer therapies. This review delves into the role of miRNAs in carcinogenesis in relation to the WNT signaling pathway along with their potential as druggable compounds.
Tracking Cancer: Exploring Heart Rate Variability Patterns by Cancer Location and Progression
Authors: Ben-David Kfir , Wittels Harrison L. , Wishon Michael J. , Lee Stephen J. , McDonald Samantha M. , Howard Wittels S.
Published: February 2024

Reduced heart rate variability (HRV) is an autonomic nervous system (ANS) response that may indicate dysfunction in the human body. Consistent evidence shows cancer patients elicit lower HRV; however, only select cancer locations were previously evaluated. Thus, the aim of the current study was to explore HRV patterns in patients diagnosed with and in varying stages of the most prevalent cancers. At a single tertiary academic medical center, 798 patients were recruited. HRV was measured via an armband monitor (Warfighter MonitorTM, Tiger Tech Solutions, Inc., Miami, FL, USA) equipped with electrocardiographic capabilities and was recorded for 5 to 7 min with patients seated in an upright position. Three time-domain metrics were calculated: SDNN (standard deviation of the NN interval), rMSSD (the root mean square of successive differences of NN intervals), and the percentage of time in which the change in successive NN intervals exceeds 50ms within a measurement (pNN50). Of the 798 patients, 399 were diagnosed with cancer. Cancer diagnoses were obtained via medical records one week following the measurement. Analysis of variance models were performed comparing the HRV patterns between different cancers, cancer stages (I–IV), and demographic strata. A total of 85% of the cancer patients had breast, gastrointestinal, genitourinary, or respiratory cancer. The cancer patients were compared to a control non-cancer patient population with similar patient size and distributions for sex, age, body mass index, and co-morbidities. For all HRV metrics, non-cancer patients exhibited significantly higher rMSSDs (11.1 to 13.9 ms, p < 0.0001), SDNNs (22.8 to 27.7 ms, p < 0.0001), and pNN50s (6.2 to 8.1%, p < 0.0001) compared to stage I or II cancer patients. This significant trend was consistently observed across each cancer location. Similarly, compared to patients with stage III or IV cancer, non-cancer patients possessed lower HRs (−11.8 to −14.0 bpm, p < 0.0001) and higher rMSSDs (+31.7 to +32.8 ms, p < 0.0001), SDNNs (+45.2 to +45.8 ms), p < 0.0001, and pNN50s (19.2 to 21.6%, p < 0.0001). The HR and HRV patterns observed did not significantly differ between cancer locations (p = 0.96 to 1.00). The depressed HRVs observed uniformly across the most prevalent cancer locations and stages appeared to occur independent of patients’ co-morbidities. This finding highlights the potentially effective use of HRV as a non-invasive tool for determining common cancer locations and their respective stages. More studies are needed to delineate the HRV patterns across different ages, between sexes and race/ethnic groups.
What Is the Role of Minimally Invasive Liver Surgery in Treating Patients with Hepatocellular Carcinoma on Cirrhosis?
Authors: Vitale Alessandro , Angelico Roberta , Sensi Bruno , Lai Quirino , Kauffmann Emanuele , Scalera Irene , Serenari Matteo , Ginesini Michael , Romano Pierluigi , Furlanetto Alessandro , D’Amico Francesco
Published: February 2024

Minimally invasive liver surgery (MILS) has been slowly introduced in the past two decades and today represents a major weapon in the fight against HCC, for several reasons. This narrative review conveys the major emerging concepts in the field. The rise in metabolic-associated steatotic liver disease (MASLD)-related HCC means that patients with significant cardiovascular risk will benefit more profoundly from MILS. The advent of efficacious therapy is leading to conversion from non-resectable to resectable cases, and therefore more patients will be able to undergo MILS. In fact, resection outcomes with MILS are superior compared to open surgery both in the short and long term. Furthermore, indications to surgery may be further expanded by its use in Child B7 patients and by the use of laparoscopic ablation, a curative technique, instead of trans-arterial approaches in cases not amenable to radiofrequency. Therefore, in a promising new approach, multi-parametric treatment hierarchy, MILS is hierarchically superior to open surgery and comes second only to liver transplantation.
Clinical Outcome after Surgical Treatment of Sacral Chordomas: A Single-Center Retrospective Cohort of 27 Patients
Authors: Goumenos Stavros , Kakouratos Georgios , Trikoupis Ioannis , Gavriil Panagiotis , Gerasimidis Pavlos , Soultanis Konstantinos , Patapis Pavlos , Kontogeorgakos Vasileios , Papagelopoulos Panayiotis
Published: February 2024

Introduction: The aims of our study were (1) to determine disease-specific and disease-free survival after the en-bloc resection of sacral chordomas and (2) to investigate potential risk factors for tumor recurrence and major postoperative wound-related complications. Methods: We retrospectively analyzed 27 consecutive patients with sacral chordomas who were surgically treated in our institution between 2004 and 2022. Three patients (11.1%) had a recurrent tumor and four patients (14.8%) had history of a second primary solid tumor prior to or after their sacral chordoma. A combined anterior and posterior approach, colostomy, plastic reconstruction, and spinopelvic instrumentation were necessitated in 51.9%, 29.6%, 37%, and 7.4% of cases, respectively. The mean duration of follow-up was 58 ± 41 months (range= 12–170). Death-related-to-disease, disease recurrence, and major surgical site complications were analyzed using Kaplan–Meier survival analysis, and investigation of the respective risk factors was performed with Cox hazard regression. Results: The estimated 5-year and 10-year disease-specific survival was 75.3% (95% CI = 49.1–87.5%) and 52.7% (95% CI = 31–73.8%), respectively. The estimated 1-year, 5-year, and 10-year disease-free survival regarding local and distant disease recurrence was 80.4% (95% CI = 60.9–91.1%), 53.9% (95% CI = 24.6–66.3%), and 38.5% (95% CI = 16.3–56.2%), respectively. The mean survival of the recurred patients was 61.7 ± 33.4 months after their tumor resection surgery. Conclusions: Despite the high relapse rates and perioperative morbidity, long-term patient survival is not severely impaired. Positive or less than 2 mm negative resection margins have a significant association with disease progression.
The Perfect Timing—Immediate versus Delayed Microvascular Reconstruction of the Mandible
Authors: Thiem Daniel G. E. , Siegberg Fabia , Vinayahalingam Shankeeth , Blatt Sebastian , Krüger Maximilian , Lethaus Bernd , Al-Nawas Bilal , Zimmerer Rüdiger , Kämmerer Peer W.
Published: February 2024

In this retrospective study, the clinical and economic implications of microvascular reconstruction of the mandible were assessed, comparing immediate versus delayed surgical approaches. Utilizing data from two German university departments for oral and maxillofacial surgery, the study included patients who underwent mandibular reconstruction following continuity resection. The data assessed included demographic information, reconstruction details, medical history, dental rehabilitation status, and flap survival rates. In total, 177 cases (131 male and 46 females; mean age: 59 years) of bony free flap reconstruction (72 immediate and 105 delayed) were included. Most patients received adjuvant treatment (81% with radiotherapy and 51% combined radiochemotherapy), primarily for tumor resection. Flap survival was not significantly influenced by the timing of reconstruction, radiotherapy status, or the mean interval (14.5 months) between resection and reconstruction. However, immediate reconstruction had consumed significantly fewer resources. The rate of implant-supported masticatory rehabilitation was only 18% overall. This study suggests that immediate jaw reconstruction is economically advantageous without impacting flap survival rates. It emphasizes patient welfare as paramount over financial aspects in clinical decisions. Furthermore, this study highlights the need for improved pathways for masticatory rehabilitation, as evidenced by only 18% of patients with implant-supported dentures, to enhance quality of life and social integration.
Forchlorfenuron-Induced Mitochondrial Respiration Inhibition and Metabolic Shifts in Endometrial Cancer
Authors: Kim Kyukwang , Khazan Negar , Rowswell-Turner Rachael B. , Singh Rakesh K. , Moore Taylor , Strawderman Myla S. , Miller John P. , Snyder Cameron W. A. , Awada Ahmad , Moore Richard G.
Published: February 2024

Forchlorfenuron (FCF) is a widely used plant cytokinin that enhances fruit quality and size in agriculture. It also serves as a crucial pharmacological tool for the inhibition of septins. However, the precise target of FCF has not yet been fully determined. This study reveals a novel target of FCF and elucidates its downstream signaling events. FCF significantly impairs mitochondrial respiration and mediates metabolic shift toward glycolysis, thus making cells more vulnerable to glycolysis inhibition. Interestingly, FCF’s impact on mitochondrial function persists, even in cells lacking septins. Furthermore, the impaired mitochondrial function leads to the degradation of HIF-1α, facilitated by increased cellular oxygen. FCF also induces AMPK activation, suppresses Erk1/2 phosphorylation, and reduces the expression of HER2, β-catenin, and PD-L1. Endometrial cancer is characterized by metabolic disorders such as diabetes and aberrant HER2/Ras-Erk1/2/β-catenin signaling. Thus, FCF may hold promise as a potential therapeutic in endometrial cancer.
Dendritic Cells in Cancer Immunology and Immunotherapy
Authors: Hato Laura , Vizcay Angel , Eguren Iñaki , Pérez-Gracia José L. , Rodríguez Javier , Gállego Pérez-Larraya Jaime , Sarobe Pablo , Inogés Susana , Díaz de Cerio Ascensión López , Santisteban Marta
Published: February 2024

Cancer immunotherapy modulates the immune system, overcomes immune escape and stimulates immune defenses against tumors. Dendritic cells (DCs) are professional promoters of immune responses against tumor antigens with the outstanding ability to coordinate the innate and adaptive immune systems. Evidence suggests that there is a decrease in both the number and function of DCs in cancer patients. Therefore, they represent a strong scaffold for therapeutic interventions. DC vaccination (DCV) is safe, and the antitumoral responses induced are well established in solid tumors. Although the addition of checkpoint inhibitors (CPIs) to chemotherapy has provided new options in the treatment of cancer, they have shown no clinical benefit in immune desert tumors or in those tumors with dysfunctional or exhausted T-cells. In this way, DC-based therapy has demonstrated the ability to modify the tumor microenvironment for immune enriched tumors and to potentiate systemic host immune responses as an active approach to treating cancer patients. Application of DCV in cancer seeks to obtain long-term antitumor responses through an improved T-cell priming by enhancing previous or generating de novo immune responses. To date, DCV has induced immune responses in the peripheral blood of patients without a significant clinical impact on outcome. Thus, improvements in vaccines formulations, selection of patients based on biomarkers and combinations with other antitumoral therapies are needed to enhance patient survival. In this work, we review the role of DCV in different solid tumors with their strengths and weaknesses, and we finally mention new trends to improve the efficacy of this immune strategy.
Beneficial Effect of Metformin on the Five-Year Survival in about 40,000 Patients with Head and Neck Cancer
Authors: Gaertner Florian , Preissner Saskia , Heiland Max , Preissner Robert , Wüster Jonas
Published: February 2024

Introduction: Even in times of new therapy regimes, the overall survival of patients with head and neck cancer remains low. Since the previous studies showed the beneficial effect of metformin medication on the survival of patients with cancer, our objective was to investigate if—and in which way—metformin medication affects the overall survival of patients with head and neck cancer. Methods: Clinical data pertaining to patients diagnosed with head and neck cancer (International Classification of Diseases 10 codes C00-C14, C31, and C32) were retrospectively retrieved from the TriNetX network (TriNetX, Cambridge, MA, USA). The initial cohort extracted from the network was stratified into two groups: patients on metformin medication (cohort I), and individuals not on metformin medication (cohort II). The matching criteria included age, gender, BMI, type 2 diabetes, and risk factors, such as nicotine and alcohol abuse/dependence. Kaplan–Meier analysis, risk analysis, and the calculation of odds and hazard ratios were conducted. Additionally, the Hemoglobin A1c values were subject to analysis. Results: Following matching, each cohort comprised 20,416 patients. Cohort I exhibited a higher five-year survival rate at 75.3%, in contrast to cohort II, which registered a rate of 69.8%. The odds ratio was 0.79 (95% CI = 0.75–0.83), and the hazard ratio was 0.78 (95% CI = 0.75–0.82). Conclusion: Metformin medication may correlate with improved five-year survival rates in patients with head and neck cancer. Since potentially influencing factors such as comorbidities and the initial tumor stage were not available, the results of our retrospectively conducted study must be interpreted with caution.
Finite Element Simulation of Orthogonal Cutting of H13-Hardened Steel to Evaluate the Influence of Coatings on Cutting Temperature
Authors: Hao Guangchao , Tang Aijun , Zhang Zhenzhong , Xing Hongyu , Xu Nan , Duan Ran
Published: February 2024

High cutting temperatures increase tool wear and reduce tool life. To achieve a longer tool life, coated carbide tools have been developed. In this study, the influence of tool coatings on the cutting temperature distribution during the orthogonal cutting of H13-hardened steel is investigated. Firstly, four coating materials, including TiC, TiN, Al2O3, and TiAlN, with the same coating thickness, are selected to evaluate the effects of coating materials on cutting temperature with finite element simulation. The maximum temperatures at the tool rake face and the temperatures at the coating–substrate interface are evaluated. It was found that the maximum temperatures at the tool rake face were the lowest and the highest when TiN and Al2O3 coating materials were applied, respectively. The TiAlN coating material had the best thermal barrier property. Then, the temperature distribution along the direction perpendicular to the tool rake face is investigated for TiAlN-coated tools with different coating thicknesses ranging from 3 μm to 10 μm. It is shown that the temperature gradient increases with the coating thickness. The coating thickness should be kept below 5 μm. Finally, cutting experiments validate the availability of the finite element model.
Enhanced Heterogeneous Graph Attention Network with a Novel Multilabel Focal Loss for Document-Level Relation Extraction
Authors: Chen Yang , Shi Bowen
Published: February 2024

Recent years have seen a rise in interest in document-level relation extraction, which is defined as extracting all relations between entities in multiple sentences of a document. Typically, there are multiple mentions corresponding to a single entity in this context. Previous research predominantly employed a holistic representation for each entity to predict relations, but this approach often overlooks valuable information contained in fine-grained entity mentions. We contend that relation prediction and inference should be grounded in specific entity mentions rather than abstract entity concepts. To address this, our paper proposes a two-stage mention-level framework based on an enhanced heterogeneous graph attention network for document-level relation extraction. Our framework employs two different strategies to model intra-sentential and inter-sentential relations between fine-grained entity mentions, yielding local mention representations for intra-sentential relation prediction and global mention representations for inter-sentential relation prediction. For inter-sentential relation prediction and inference, we propose an enhanced heterogeneous graph attention network to better model the long-distance semantic relationships and design an entity-coreference path-based inference strategy to conduct relation inference. Moreover, we introduce a novel cross-entropy-based multilabel focal loss function to address the class imbalance problem and multilabel prediction simultaneously. Comprehensive experiments have been conducted to verify the effectiveness of our framework. Experimental results show that our approach significantly outperforms the existing methods.
How Do Nitrogen Deposition, Mowing, and Deer Grazing Drive Vegetation Changes on Dune Heaths?
Authors: Kaae Mathias Emil , Hu Fenjuan , Bak Jesper Leth , Strandberg Morten Tune , Damgaard Christian Frølund
Published: February 2024

Heathland vegetation has undergone significant changes in the past century, e.g., due to airborne pollutants and a lack of proper management. Understanding the interactions between these factors in combination is pivotal for heathland conservation. Here, we studied the vegetation changes at a dune heath in a four-year manipulation experiment analysing the combined effects of nitrogen deposition, mowing, and deer grazing. Our results showed no significant effect of nitrogen deposition and deer grazing on plant growth and cover of dwarf shrubs within the experimental plots. However, high loads of nitrogen decreased bryophyte cover and increased the growth and cover of sand sedge Carex arenaria L. Mowing adversely affected the dwarf shrub community, e.g., the dwarf shrub species crowberry Empetrum nigrum L., and facilitated increased cover and plant growth of graminoids. Plant growth and the cover of C. arenaria increased in plots without deer grazing, whereas bryophyte cover decreased significantly without grazing. We do not recommend intensive mowing of vegetation as a conservation method for dune heaths because it promotes graminoids. From a conservation aspect, it is essential to consider the effect of deer on heathlands because they both impede some species and benefit others and mitigate the adverse effects of nitrogen deposition on dune heaths.
Odonata, Coleoptera, and Heteroptera (OCH) Trait-Based Biomonitoring of Rivers within the Northwestern Rif of Morocco: Exploring the Responses of Traits to Prevailing Environmental Gradients
Authors: El Yaagoubi Sara , Edegbene Augustine Ovie , El Haissoufi Mohamed , Harrak Rihab , El Alami Majida
Published: February 2024

This study aimed to determine the impact of various pressures on the functional composition of OCH (Odonata, Coleoptera, and Heteroptera) in streams within the northwest Rif region of Morocco. We examined how OCH traits respond to human-induced pressures in selected stream sites in Morocco’s northwestern Rif region. OCH specimens were collected from 36 sites using a Surber sampler with dimension of 20 × 20 cm and mesh size of 500 µm over the course of two years, from 2021 to 2023. We measured physico-chemical and hydraulic parameters such as temperature, pH, DO, and NO-3. Sixty-seven trait attributes from 11 trait classes were assigned to the collected OCH taxa at the family level. Following the delineation of sites along the gradient of impacts in the study area, we categorized 7 sites as slightly impacted sites (SISs), 19 sites as moderately impacted sites (MISs), and 10 sites as heavily impacted sites (HISs). We successfully identified and categorized the traits as either vulnerable or tolerant based on RLQ models. Traits such as reproductive cycles per year and tegument respiration, which were positively correlated with SISs in the RLQ model and also positively correlated with depth and chlorine, were identified as vulnerable traits. Crawling locomotion and full water swimming were identified as tolerant traits. The distribution patterns of the OCH taxa revealed a robust correlation between the taxa and the sampling sites. Notably, taxa such as Nepidae, Naucoridae, and Corixidae exhibited widespread distribution and a strong association with the SISs. On the other hand, traits related to living macroinvertebrate food sources and reproduction in vegetation, specifically clutches, exhibited a negative correlation with total dissolved solids. Incorporating OCH functional traits into biomonitoring programs allows for a more comprehensive assessment of river ecosystems. This approach provides a nuanced understanding of how different stressors impact the community composition and overall ecological health.
n77 Radio Frequency Power Amplifier Module for 5G New-Radio High-Power User Equipment Mobile Handset Applications
Authors: Paek Ji-Seon
Published: February 2024

This paper presents a highly efficient 5G New-Radio (NR) RF power amplifier module (PAM). The n77 PAM consists of a high-voltage differential-topology 2 μm GaAs HBT power amplifier, a CMOS controller, a silicon-on-insulator (SOI) switch, an integrated passive device (IPD) bandpass filter, a low-noise amplifier (LNA), and a bi-directional coupler. This PAM generates a saturation output power of 32.7 dBm including the loss of the SOI switch and output filter. The designed n77 PAM is tested with a commercial envelope tracker IC (ET-IC). The designed PAM with an ET-IC achieves an ACLR of −37 dBc at a 27 dBm output power with a DFT-s-OFDM QPSK 100 MHz NR signal and saves a dc power consumption of 950 mW compared to the APT mode. For the CP-OFDM 256QAM with the most stringent EVM requirements, it achieves an EVM of 1.22% at 23 dBm and saves 640 mW compared to the APT mode.
Design of UWB Electrically Small Antenna Based on Distributed Passive Network Loading
Authors: Chen Zhe , Lin Xianqi , Luan Yuchen , Hao Xinjie , Yan Xiaoming , Liu Guo
Published: February 2024

In this paper, an ultra-wideband electrically small antenna based on distributed passive network loading is proposed. Based on the Vivaldi antenna theory, magnetic dipole antenna theory, and distributed loading theory, the electrically small antenna achieves the purpose of being wideband using a three-dimensional design of a planar Vivaldi antenna structure under limited space constraints. At the same time, the magnetic dipole antenna is introduced to effectively expand the low-frequency bandwidth of the electrically small antenna without increasing the aperture size. Finally, through the distributed passive network loading, the wideband-conjugated matching of the electrically small antenna is achieved without increasing the size of the electrically small antenna. The −6 dB bandwidth of the electrically small antenna is 0.2 GHz–3 GHz, and the overall size is 0.06 λ0 × 0.05 λ0 × 0.12 λ0, where λ0 is the wavelength of the lowest frequency of the antenna. One sample of the proposed UWB electrically small antenna is fabricated and tested. Good agreement between simulation results and measurement results are obtained. The design method of UWB electrically small antenna proposed in this paper can be applied to the base station antenna, low-frequency detection, microwave sensing, and microwave measurement.
ATCNet: A Novel Approach for Predicting Highway Visibility Using Attention-Enhanced Transformer–Capsule Networks
Authors: Li Wen , Yang Xuekun , Yuan Guowu , Xu Dan
Published: February 2024

Meteorological disasters on highways can significantly reduce road traffic efficiency. Low visibility caused by dense fog is a severe meteorological disaster that greatly increases the incidence of traffic accidents on highways. Accurately predicting highway visibility and taking timely countermeasures can mitigate the impact of meteorological disasters and enhance traffic safety. This paper introduces the ATCNet model for highway visibility prediction. In ATCNet, we integrate Transformer, Capsule Networks (CapsNet), and self-attention mechanisms to leverage their respective complementary strengths. The Transformer component effectively captures the temporal characteristics of the data, while the Capsule Network efficiently decodes the spatial correlations and hierarchical structures among multidimensional meteorological elements. The self-attention mechanism, serving as the final decision-refining step, ensures that all key temporal and spatial hierarchical information is fully considered, significantly enhancing the accuracy and reliability of the predictions. This integrated approach is crucial in understanding highway visibility prediction tasks influenced by temporal variations and spatial complexities. Additionally, this study provides a self-collected publicly available dataset, WD13VIS, for meteorological research related to highway traffic in high-altitude mountain areas. This study evaluates the model’s performance in terms of Mean Squared Error (MSE) and Mean Absolute Error (MAE). Experimental results show that our ATCNet reduces the MSE and MAE by 1.21% and 3.7% on the WD13VIS dataset compared to the latest time series prediction model architecture. On the comparative dataset WDVigoVis, our ATCNet reduces the MSE and MAE by 2.05% and 5.4%, respectively. Our model’s predictions are accurate and effective, and our model shows significant progress compared to competing models, demonstrating strong universality. This model has been integrated into practical systems and has achieved positive results.
Pore Structure and Factors Controlling Shale Reservoir Quality: A Case Study of Chang 7 Formation in the Southern Ordos Basin, China
Authors: Li Qing , You Xuelian , Li Jiangshan , Zhou Yuan , Lu Hao , Wu Shenghe , Yue Dali , Zhang Houmin
Published: February 2024

The lithofacies types, pore structure differences, and main controlling factors on the shale reservoirs are vital problems that need to be addressed in the process of shale oil exploration and development. This study explores the Luohe oilfield in the southern Ordos Basin, which is composed of organic-rich shale in the Chang 7 member, to clarify the reservoir properties and analyze major factors affecting the reservoir quality. The shale reservoir can be divided into five lithofacies using ternary diagrams of TOC, argillaceous minerals, and siliceous minerals: high organic-rich siliceous shale (HOSS), high organic-rich argillaceous shale (HOAS), medium organic-rich siliceous shale (MOSS), medium organic-rich argillaceous shale (MOAS), and low organic-rich shale (LOS). The type of organic matter in the studied samples is mainly Type I kerogen and Type II kerogen, predominantly Type II1 kerogen. The kerogen mostly lie within the mature zone in the study area. Various types of pores have been identified in the studied shale: intergranular pores, intragranular pores, intercrystalline pores, organic matter pores, and seams around organic matter. The pores are commonly nanoscale to micrometer in scale, with diameters ranging from 10 nm to several microns. The S1 content in shale is positively correlated with the macropore content, indicating that macropores in shale are the main effective oil storage spaces and are important for oil-bearing reservoirs. There is a good positive relationship between the macropore volume of shale and the content of organic matter. Organic matter in the shale can be beneficial for generating organic matter pores, dissolution pores, and seams at organic matter edge, resulting in better physical properties of shale reservoirs. There is a negative relationship between the quartz/feldspar content and macropores content, indicating that quartz and feldspar are detrimental for the macropore volume development. The lithofacies type is one of the important factors controlling the macropore volume. MOAS and HOAS are favorable lithofacies for the development of macropores. The findings of this study can be utilized for hydrocarbon exploration and development in the lacustrine shale formation of the Ordos Basin and other similar basins.
Research and Application of Carbon Capture, Utilization, and Storage–Enhanced Oil Recovery Reservoir Screening Criteria and Method for Continental Reservoirs in China
Authors: Cao Jinhong , Gao Ming , Liu Zhaoxia , Yu Hongwei , Liu Wanlu , Yin Hengfei
Published: February 2024

CCUS-EOR is a crucial technology for reducing carbon emissions and enhancing reservoir recovery. It enables the achievement of dual objectives: improving economic efficiency and protecting the environment. To explore a set of CCUS-EOR reservoir screening criteria suitable for continental reservoirs in China, this study investigated and compared the CCUS-EOR reservoir screening criteria outside and in China, sorted out the main reservoir parameters that affect CO2 flooding, and optimized the indices and scope of CCUS-EOR reservoir screening criteria in China. The weights of parameters with respect to their influences on CCUS-EOR were determined through principal component analysis. The results show that there are 14 key parameters affecting CO2 flooding, which can be categorized into four levels. For the first level, the crude oil-CO2 miscibility index holds the greatest weight of 0.479. It encompasses seven parameters: initial formation pressure, current formation pressure, temperature, depth, C2–C15 molar content, residual oil saturation, and minimum miscibility pressure. The second level consists of the crude oil mobility index, which has a weight of 0.249. This index includes four parameters: porosity, permeability, density, and viscosity. The third level pertains to the index of reservoir tectonic characteristics, with a weight of 0.141. It comprises two parameters: permeability variation coefficient and average effective thickness. Lastly, the fourth level focuses on the index of reservoir property change, with a weight of 0.131, which solely considers the pressure maintenance level. Based on the CCUS-EOR reservoir screening criteria and index weights established in this study, comprehensive scores for CCUS-EOR were calculated for six blocks in China. Among these, five blocks are deemed suitable for CCUS-EOR. Based on the comprehensive scoring results, a planning for field application of CCUS-EOR is proposed. The study provides a rational method to evaluate the CCUS-EOR reservoir screening and field application in continental reservoirs in China.
Insulation Resistance Characteristics of Dry DC Link Capacitors in the Presence of High Temperatures and Operating Voltages
Authors: Sun Xiaowu , Qiao Ying , Li Yinda , Cao Chongfeng , Feng Shenrong
Published: February 2024

Insulation resistance is a vital factor in dry DC link capacitors (DCLCs), and crucially influences their voltage equalization and energy storage performance. However, at present, there is a lack of experimental observation on the insulation resistance characteristics of DCLCs in the presence of high temperatures and operating voltages. In the present study, the insulation resistance and conductivity of DCLCs are methodically analyzed. For this purpose, the corresponding test platform is appropriately fabricated, the insulation resistance measurement experiments are performed at various temperatures and operating voltages, and the factors affecting the insulation resistance and conductivity of the DCLC are carefully examined. The results reveal that the insulation resistance of the DCLC reduces exponentially with the growth in voltage and operating temperature. When the operating voltage becomes greater than 4480 V or the operating temperature reaches higher than 70 °C, the decline in insulation resistance slows down. The conductivity of metalized polypropylene film in the DCLC increases exponentially with increasing voltage and temperature. By increasing the operating voltage from 1960 V to 5600 V and the temperature from 20 °C to 90 °C, the DCLC’s insulation resistance exhibits a descending trend from 891.30 MΩ to 2.14 MΩ, while its conductivity grows from 3.49 × 10−16 S/m to 1.47 × 10−13 S/m. The results reveal that the key factors affecting the insulation resistance of the DCLC are the polypropylene film and the metal evaporated from the metal layer. This research is anticipated to provide a valuable reference for the further development of science and technology pertinent to the insulation resistance of DCLCs.
Method of Reducing Energy Consumption during Forklift Operator Training in Cargo Terminals Utilizing Virtual Reality
Authors: Kierzkowski Artur , Ryczyński Jacek , Kisiel Tomasz
Published: February 2024

In the era of shrinking resources of traditional fossil fuels and the increasingly dominant sustainable development policy, actions are taken to reduce energy consumption as much as possible, assuming that we achieve identical operational goals. These activities are apparent in the industries with the most significant energy demand, i.e., the aviation industry. To achieve this, these industries implement modern technologies in all possible areas of operation. One of these areas is the area of operator training, especially the most energy-consuming devices and types of equipment. This article investigated the potential of virtual reality (VR) technology for energy optimization of forklift operating training in airport cargo terminals. The authors propose a method whose practical implementation in one of the cargo terminals reduced energy consumption by several times while training forklift operators. The added value is that the method is universal and, after appropriate modification, can be used to train operators of other devices. The study compared traditional training methods with a VR-based training approach, assessing their impact on energy consumption and overall efficiency of forklift operations in airport cargo terminals. The results prove that VR technology training can significantly reduce energy consumption while improving operational efficiency and can offer a sustainable and effective training solution for the entire logistics sector.
Production of Bamboo Source Microbial Fertilizer and Evaluate Its Effect on Soil Organic Carbon Fractions in Moso Bamboo Plantations in South China
Authors: Li Qiaoling , Huang Zhiyuan , Zhong Zheke , Bian Fangyuan , Zhang Xiaoping
Published: February 2024

Bamboo shoot processing wastewater (BBPW) is rich in organic matter and organic acids and can be used as a nutrient source for microbial growth and biofertilization. In this study, Pseudomonas K22-D and Terribacillus goriness CS3 were isolated from bamboo forest soil with plant growth-promoting properties. Biofertilizers were prepared by inoculating bacteria into BBPW, and the effects of their application in a bamboo forest were evaluated. The chemical oxygen demand, TOC, TN, and NH4-N contents decreased after inoculation, indicating that the bacteria were able to degrade macromolecules in BBPW. The BBPW biofertilizer produced by mixed bacteria (CS3 + K22-D) significantly improved the soil organic carbon and mineral-associated organic carbon content and reduced the pH, alkali-hydrolysable nitrogen, available phosphorus, and available potassium content of the soils in the bamboo forest, which might be attributed to the high C:N ratio and microbial synergism in the biofertilizer and the fast growth period of bamboo shoots. Notably, the CS3 biofertilizer significantly increased soil-available phosphorus (90.25%), and the K22-D biofertilizer significantly decreased soil-available phosphorus (70.33%) compared with CK, suggesting that the presence of inorganic phosphorus-solubilizing bacteria can promote soil P. We believe that the return of inoculated bamboo shoot processing wastewater to bamboo plantations can be an eco-friendly, sustainable practice for bamboo forest management.
Effects of Flow Turbulence on the Entire Development Process of Drifting Fish Eggs
Authors: Wei Yuchong , Ma Aixing , Deng Ya , Cao Minxiong , Hu Ying , Cheng Zhaoyi , Zhu Lijun
Published: February 2024

Excessive flow turbulence poses a threat to the development of drifting fish eggs, leading to mortality or developmental malformations and ultimately depleting early fish resources. Currently, there is a scarcity of quantitative studies investigating the effects of flow turbulence on the entire process of drifting fish egg development, from fertilized egg division to hatching. In this paper, the effects of different flow turbulence conditions (FTCs), including turbulent kinetic energy and shear stress, and action times on different stages of fish egg development were quantitatively explored using a transverse-oscillating-grids turbulence tank. Empirical formulas were established to predict the proportion of normal fish egg development under different FTCs within a selected range. The research findings provide a quantitative basis for protecting early fish resources, mitigating the biological invasion of specific fish, constructing fish-breeding facilities, and ensuring safe transfer and transportation.
Cardiac Transcriptome and Histology of the Heart of the Male Chinese Mitten Crab (Eriocheir sinensis) under High-Temperature Stress
Authors: Pan Tingshuang , Li Tong , Yang Min , Jiang He , Ling Jun , Gao Qian
Published: February 2024

High temperatures are important environmental stressors affecting the metabolism, growth, immunity, and mortality of Chinese mitten crabs (Eriocheir sinensis). In this study, Chinese mitten crabs were divided into two groups and exposed to temperatures of 35 °C (thermal stress group) or 25 °C (control group) for 24 h, and the transcriptome of the heart was analyzed. There were 4007 differentially expressed genes (DEGs) between the thermal stress and the control groups, including 2660 upregulated and 1347 downregulated genes. Heat shock proteins (HSPs) and transcription factors (TFs) were temperature-sensitive DEGs in Chinese mitten crabs. DEGs mainly focused on protein processing in the endoplasmic reticulum, ribosome biogenesis, glycine, serine, and threonine metabolism, protein export, and insect hormone biosynthesis pathways. A total of 28,916 SSRs and 59 TF families, including 851 TFs, were detected among all unigenes of E. sinensis transcripts. The qRT-PCR results for the HSPs and apoptotic DEGs from the heart exhibited the same trends as those in the E. sinensis transcriptome data. Results of light microscopy analyzing histological sections of the heart indicated that most myocardial fibers were lysed, and the number of nuclei and the connective tissue contents between the myocardial layers were both reduced following 35 °C exposure for 24 h.
Effect of Ultrasonic Treatment on the Physicochemical Properties of Bovine Plasma Protein-Carboxymethyl Cellulose Composite Gel
Authors: Wang Liyuan , Ma Yu , Shen Ruheng , Zhang Li , He Long , Qu Yuling , Ma Xiaotong , Ma Guoyuan , Guo Zhaobin , Chen Cheng , Li Hongbo , Kong Xiangying
Published: February 2024

In order to improve the stability of bovine plasma protein-carboxymethyl cellulose composite gels and to expand the utilization of animal by-product resources, this study investigated the impact of different ultrasound powers (300, 400, 500, 600, and 700 W) and ultrasound times (0, 10, 20, 30, and 40 min) on the functional properties, secondary structure and intermolecular forces of bovine plasma protein-carboxymethyl cellulose composite gel. The results showed that moderate ultrasonication resulted in the enhancement of gel strength, water holding capacity and thermal stability of the composite gels, the disruption of hydrogen bonding and hydrophobic interactions between gel molecules, the alteration and unfolding of the internal structure of the gels, and the stabilization of the dispersion state by electrostatic repulsive forces between the protein particles. The content of α-helices, β-turns, and β-sheets increased and the content of random curls decreased after sonication (p < 0.05). In summary, appropriate ultrasound power and time can significantly improve the functional and structural properties of composite gels. It was found that controlling the thermal aggregation behavior of composite gels by adjusting the ultrasonic power and time is an effective strategy to enable the optimization of composite gel texture and water retention properties.
Power Quality Conditioners-Based Fractional-Order PID Controllers Using Hybrid Jellyfish Search and Particle Swarm Algorithm for Power Quality Enhancement
Authors: Aldosary Abdallah
Published: February 2024

Power quality (PQ) is a major issue in today’s electrical system that affects both utilities and customers. The proliferation of power electronics devices, smart grid technology, and renewable energy sources (RES) have all contributed to the emergence of PQ concerns in today’s power system. The Unified Power Quality Conditioner (UPQC) is a versatile tool that can be used to fix distribution grid issues caused by irregular voltage, current, or frequency. Several tuning parameters, however, restrict the effectiveness of the Fractional-Order Proportional Integral Derivative (FOPID) control technique, which is proposed to improve UPQC performance. To move beyond these restrictions and find the optimal solution for the FOPID controller problem, a hybrid optimization strategy called the Hybrid Jellyfish Search Optimizer and Particle Swarm Optimizer (HJSPSO) is employed. To meet the load requirement during PQ issue periods, the suggested model incorporates a renewable energy source into the grid system. Whether the load is linear or non-linear, the design maintains PQ problems to a minimum. Furthermore, the FOPID control technique is compared with other controllers. Results show that grid-connected RES systems using the proposed FOPID control approach for UPQC have fewer PQ problems. The presented UPQC with HJSPSO strategy significantly outperformed, with the shortest computing time of 127.474 s and an objective function value of 1.423.
Novel Pathogenic Variants Leading to Sporadic Amyotrophic Lateral Sclerosis in Greek Patients
Authors: Ivantsik Ouliana , John Anne , Kydonopoulou Kyriaki , Mitropoulos Konstantinos , Gerou Spyridon , Ali Bassam R. , Patrinos George P.
Published: February 2024

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive disease that affects motor neurons, leading to paralysis and death usually 3–5 years after the onset of symptoms. The investigation of both sporadic and familial ALS highlighted four main genes that contribute to the pathogenesis of the disease: SOD1, FUS, TARDBP and C9orf72. This study aims to provide a comprehensive investigation of genetic variants found in SOD1, FUS and TARDBP genes in Greek sporadic ALS (sALS) cases. Our sequencing analysis of the coding regions of the abovementioned genes that include the majority of the variants that lead to ALS in 32 sALS patients and 3 healthy relatives revealed 6 variants in SOD1, 19 variants in FUS and 37 variants in TARDBP, of which the SOD1 p.D90A and the FUS c.*356G>A (rs886051940) variants have been previously associated with ALS, while two novel nonsense pathogenic variants were also identified, namely FUS p.R241* and TDP-43 p.Y214*. Our study contributes to the worldwide effort toward clarifying the genetic basis of sALS to better understand the disease’s molecular pathology.