bluuebunny/crossref_metadata_2025 huggingface dataset:
Interpretation of the Nature of Dementia in a Context of Humanism and Transhumanism Polemic
Authors:   Ural State Medical University, Sidenkova Alena P. , Myakotnykh Victor S. ,   Ural State Medical University, Ivanchenko Mariia A. ,   Ural Federal University named after B.N. Yeltsin
Published: February 2023

The article examines the phenomenon of dementia from the point of view of two approaches: humanism and transhumanism. The psychological and philosophi­cal interpretation of this neurodegenerative disease is given by the example of works of such philosophers and scientists as: I. Kant, M. Heidegger, E. Hus­serl, Aristotle, V.E. Frankl, D.J. Chalmers, K. Charmaz, T. Kitwood, M.P. Lauren­tiu, E. van Wijngaarden, F. Svenaeus, Ch. Taylor, S. Post, A. Giddens, E. Cassel, C. Gilleard. The analysis of general philosophical terms “mind”, “consciousness”, “intentionality”, “human”, “human nature”, “image of human”, “nothingness” is carried out. The work examines the prospects for the treatment and prevention of dementia using the achievements of NBIС-technologies, as well as the meth­ods proposed by transhumanism: the creation of an exocortex, genetic editing, digitization of consciousness, cyborgization of an individual, cloning, organ grow­ing and other methods. Inseparable from neurodegenerative and mental diseases, the phenomena of stigmatization, as well as nothingness (nihilation as a process) in the Heideggerian sense of the word, are studied. The criticism of transhuman­ism and humanism is consistently carried out in relation to the effectiveness of treatment of mental illness in general and dementia in particular. The right of transhumanism to invade the sphere of moral and ethical imperatives, medical practice and deontology, as well as human self-identity and rationality is as­sessed. The understanding of such phenomena as pain, illness, suffering and death is carried out in the context of a discussion between the humanistic para­digm and the transhumanistic vision of the world. The process of renewal of hu­manism and the transition to antihumanism or metahumanism are assumed to be the determining factors in the further development of philosophical thought, in its mutual influence on science, medicine and technology.
Dawkins, Morality, and Religion Part II. The Trolley Problem
Authors:   V.I. Vernadsky Crimean Federal University, Karabykov Anton V.
Published: February 2023

In an effort to substantiate the fundamental areligiosity of morality and the amo­rality of religion, Richard Dawkins develops the argument from a universal moral ability that has evolutionary genesis and is therefore inherent in people, re­gardless of their religious beliefs. In his book The God Delusion (2006), he uses the results of a thought experiment conducted by M. Hauser and P. Singer, who were the first to put forward this argument, claiming that their test did not reveal noticeable differences in the moral modus cogitandi of believers and atheists. The aim of the article is to give a critical analysis of that argument as based on a false presumption. It is reduced to opposition: either morality has arisen in the course of natural evolution, and then religion has nothing to do with it – or morality has been the supernatural gift of God, and then evolution has nothing to do with it. The author proves that the results of the experiment do not give grounds for the ideological conclusions that those advocates of atheism build on them.
The effect of Multi-Theory model educational intervention on preventive behaviors of Covid-19 in Yazd students: a protocol study
Authors: Mahmoodabad Seyed Saeed Mazloomy , yoshany nooshin , Moori Mahdieh Khaleghi , Morowatisharifabad Mohammad , Yazdi Mohammad Sharif , Shamsi Farimah , Hanna Fahad
Published: February 2023

Introduction: Identifying preventive behaviors from Covid-19 can be useful for planning short-term and long-term interventions for students washing hands, wearing masks and receiving vaccines. The aim of this study is to investigate the effect of educational intervention based on multi-theory model on preventive behaviors of Covid-19 in students in Yazd.
Methods and analysis: This study will be a randomized controlled trial based on case and control groups on undergraduate students in Yazd universities. Received a clinical trial code and an ethics code in the research. The random cluster sampling method will be two-step. The data collection tool is a questionnaire consisting of 4 parts: the first part is demographic information, the second part is a hand washing behavior questionnaire based on a multi-theory model, the third part is a vaccine acceptance behavior questionnaire based on a multi-theory model, the fourth part is a questionnaire The behavior of wearing a mask is based on a multi-theory model. Questionnaires will be completed in 2 rounds. First before the intervention and one month after the intervention. After completing the pre-test, an educational intervention based on the multi-theory model will be performed for the case group and no intervention will be performed for the control group. Data analysis will be performed in SPSS software version 24.
Ethics and dissemination: The ethical approval of this research was obtained by the Ethics Committee of Shahid Sadoughi University of Medical Sciences, Yazd. (Approval date: 9/24/1400) Reference number: IR.SSU.SPH.REC.1400.179. The results will be disseminated through peer-reviewed journals and conferences. The present study was carried out in accordance with the Declaration of Helsinki and approved by IRCT. The participants of this study were students, they were not patient, no special intervention was done on them, we only gave them a series of trainings to increase their awareness about preventive behaviors of COVID-19.
Trial registration number: IRCT20211226053527N1
Distributed non-disclosive validation of predictive models by a modified ROC-GLM
Authors: Schalk Daniel , Hoffmann Verena S. , Bischl Bernd , Mansmann Ulrich
Published: February 2023

Background: Distributed statistical analyses provide a promising approach for privacy protection when analyzing data distributed over several databases. This approach brings the analysis to the data, rather than the data to the analysis. Instead of directly operating on data, the analyst receives anonymous summary statistics, which are combined into an aggregated result. Further, in model development, it is key to evaluate a trained model w.r.t. to its prognostic or predictive performance. For binary classification, one technique is analyzing the receiver operating characteristics (ROC). Hence, we are interested to calculate the area under the curve (AUC) and ROC curve for a binary classification task using a distributed and privacy-preserving approach.
Methods: We employ DataSHIELD as the technology to carry out distributed analyses, and we use a newly developed algorithm to validate the prediction score by conducting distributed and privacy-preserving ROC analysis. Calibration curves are constructed from mean values over sites. The determination of ROC and its AUC is based on a generalized linear model (GLM) approximation of the ROC curve, the ROC-GLM, as well as on ideas of differential privacy (DP). DP adds noise (quantified by the ℓ2 sensitivity Δ2( ˆf)) to the data. The appropriate choice of the ℓ2 sensitivity was studied by simulations.
Results: In our simulation scenario, the true and distributed AUC measures differ by ΔAUC < 0.01 depending on the choice of the differential privacy parameters. It is recommended to check the accuracy of the distributed AUC estimator in specific simulation scenarios when Δ2(ˆf) > 0.07. Here, the accuracy of the distributed AUC estimator may be impaired by too much artificial noise added from DP.
Conclusions: The applicability of our algorithms depends on the sensitivity of the underlying statistical/predictive model. The simulations carried out have shown that the approximation error is acceptable for the majority of simulated cases. For models with high sensitivity, the privacy parameters must be set accordingly higher to ensure sufficient privacy protection, which affects the approximation error. This work shows that complex measures, as the AUC, are applicable for validation in distributed setups while preserving an individual’s privacy.
The Drosophila Epidermal growth factor regulates Hedgehog-signalling cytoneme dynamics.
Authors: Gradilla Ana , Sánchez-Hernández David , Jiménez-Jiménez Carlos , Jordán-Álvarez Sheila , Aguirre-Tamaral Adrián , Sánchez Irene , Wakefield James , Guerrero Isabel
Published: February 2023

During Drosophila epithelial development, signalling specialized filopodial or cytonemes establish direct contacts between distant cells to facilitate the formation of the Hedgehog (Hh) signalling gradient. However, the regulatory mechanisms for Hh cytoneme initiation and their dynamic behaviour are still unknown. Here we show that Hh cytoneme dynamics in Drosophila epithelia depends on the Epidermal Growth Factor (EGF) signalling pathway through its ligand Spitz. We describe that the EGF pathway is required to maintain basal plasma membrane levels of the adhesion protein and Hh co-receptor Ihog, able to modify cyoneme behaviour. Furthermore, we describe that EGF signalling promotes Ihog interaction with actin cytoskeleton regulators, such as the actin cross-linker Filamin A, Cheerio (Che) in Drosophila. Cheerio is recruited by Ihog towards focalized small regions of the plasma membrane to contribute to the cytoneme stabilization function of Ihog. Finally, we describe that EGF regulation and PI3K signalling act synergically on Hh cytoneme behaviour, revealing a new form of cooperation between major tissue organizers.
Highly purified-hMG versus rFSH in ovarian hyperstimulation in women undergoing elective fertility preservation
Authors: Israeli Tal , Samara Nivin , Barda Shimi , Groutz Asnat , Azem Foad , Amir Hadar
Published: February 2023

Purpose: To compare recombinant FSH (rFSH) with highly purified-human menopausal gonadotrophin (hp-hMG) on ovarian response in women undergoing elective fertility preservation (FP).
Methods: This retrospective study included 456 women who underwent elective FP with gonadotropin-releasing hormone (GnRH) antagonist or progestin-primed ovarian stimulation (PPOS) protocols between 01/2017-12/2021. Three-hundred and forty-one women were stimulated with rFSH and 115 with hp-hMG, and the ovarian stimulation outcomes were compared between the two groups. A multivariate linear regression analysis assessed the impact of age, basal FSH level, antral follicle count, and protocol type on the ovarian stimulation outcomes.
Results: Women in the rFSH group were significantly younger, and their antral follicle count was significantly higher than those in the hp-hMG group (35.50±2.12 vs. 35.99±2.13 years, P = 0.034 and 13.76±6.08 vs. 11.84±6.06, P = 0.002). There were no significant group differences in the amount (P = 0.645) and duration (P = 0.265) of FSH stimulation. The peak estradiol level was significantly lower for the rFSH group compared to the hp-hMG group (2547.18±1648.21 pg/mL vs. 3468.02±2497.69 pg/mL, P < 0.001), while peak progesterone level was significantly higher (1.33±0.75 ng/mL vs. 1.01±0.52 ng/mL, P = 0.001). The numbers of retrieved and MII oocytes were significantly higher for the rFSH group compared with the hp-hMG group (16.82±10.95 vs. 13.25±9.66, P = 0.02, and 13.22±9.13 vs. 9.76±7.11, P = 0.005), while the maturity rates were comparable (P = 0.103).
Conclusion: rFSH was demonstrated to have superior oocyte yield compared to hp-hMG in ovarian hyperstimulation for women undergoing elective FP.
Bacterial nanocellulose membranes for codelivery of carvacrol and thymol: physico-chemical characterization and in vitro studies
Authors: Gabbai-Armelin Paulo Roberto , De Oliveira Analu , Rodero Camila , Silva Jhonatan , Fernandes Natalie , Paiva Robert , Dametto Alessandra , Chorilli Marlus , Barud Hernane , Brighenti Fernanda
Published: February 2023

Skin wounds represent a worldwide problem. Biopolymers have been attracting interest for healthcare products toward wound dressing. Among these biopolymers, bacterial nanocellulose membranes (BNC), with its tridimensional and branched nano- and microfibrillar structure, are attractive. Despite that, BNC present no antimicrobial activity. Thus, the incorporation of the monoterpenes Carvacrol (Car) and Thymol (Thy) - which present antimicrobial and healing properties - toward the improvement of skin wound healing, consists of an appealing approach. This research aimed to produce and characterize nanocellulose membranes containing carvacrol and/or thymol, and investigate their release behavior, cytotoxicity and antimicrobial properties. BNC/Car, BNC/Thy and BNC/Car-Thy membranes were produced at doses of 0.1 and 1.0 mg/cm2. The natural components incorporation into the nanocellulose did not interfere neither on ultra-structure nor on its physic characteristics. Release experiments showed a burst release between 2–4 h with sustained release till 24 h, reaching around 80% of the initial amount of the incorporated monoterpenes. Studies with fibroblast and keratinocytes indicated no cytotoxicity and that cells could proliferate over the BNC/Car-Thy membranes. Microbiological studies suggested some antimicrobial potential of the BNC doped with Car and Thy. This innovative biomaterial has the potential for health care products.
AURKB activates EMT through PI3K/AKT signaling axis to promote ICC progression
Authors: Ma Peng , Hao Ying , Wang Wei , Zhang Yue-Feng , Yu Kai-Huan , Wang Wei-Xing
Published: February 2023

Intrahepatic cholangiocarcinoma (ICC) is a fatal disease and the molecular mechanism of its progression is unknown. Aurora Kinase B (AURKB) is a central regulator of chromosome separation and cytokinesis and is abnormally expressed in a variety of cancer cells. This research aimed to explore the effect of AURKB in occurrence and metastasis of ICC. We found that AURKB showed a progressive up-regulation pattern from normal bile duct tissue to ICC with high invasion. Our data showed that AURKB significantly promoted ICC cell proliferation, induced epithelial-mesenchymal transition (EMT), migration and invasion through gain- and loss- of function experiments. In vivo results consistently showed that AURKB up-regulation not only promoted tumor growth, but also promoted tumor metastasis. Importantly, we discovered that AURKB regulates the expressions of EMT-related genes via PI3K/AKT signaling axis. Thus, our results suggest that AURKB induced EMT through the activation of PI3K/AKT signaling pathway is critical to the progression of ICC, which may be a prospective therapeutic treatment for overcoming ICC metastasis and progression.
Finite element analysis on pushing the molar backwards using invisible aligner with different migration displacement
Authors: Zhang J. W. , Ma L. L. , Ren Y. Z.X. , Zhou Y. Q. , Wei R. , Rong Q. G.
Published: February 2023

This paper examines the biomechanical mechanism behind the effect of the invisible aligner technique on tooth movement processes. To compare the effects of different target positions on tooth movement and the periodontal ligament (PDL), two kinds of aligners were designed to provide displacements of 0.2 mm and 0.3 mm. Different displacements of the maxillary second molar were simulated using the finite element (FE) method. The results of numerical simulations showed that the maximum stress was in the PDL of the distal surface and the palatal surface. The aligner that provided a displacement of 0.2 mm was more suitable for pushing the second molar backwards in the initial stage. In addition, the displacement and rotation of teeth during orthodontic treatment were measured and analysed.
Production of biodiesel from non-edible Parkia biglobosa oil under acidic condition
Authors: Takase Mohammed , Kipkoech Rogers
Published: February 2023

In this study biodiesel was produced from Parkia biglobosa via optimization of transesterification reaction condition (methanol to oil ratio, catalyst concentration, reaction temperature and reaction time) under sulphuric acid catalyst (H2SO4). Oil was first extracted from Parkia biglobosa seeds using soxhlet extraction method. The physico-chemical properties of the biodiesel were analysed and then compared to international standards. Subsequently, the oil was then used to produce biodiesel at optimized transesterification reaction conditions. At the end, the free fatty acid (FFA) content of the oil was 1.61% w/w while the saponification value (mgKOH/g) was 191.65. The maximum yield (percentage weight) of the biodiesel produced was 93.4% at the maximum transesterification conditions of methanol to oil molar ratio of 6:1, sulphuric acid catalyst amount of 3 wt %, reaction temperature of 65\(℃\) and reaction time of 1.5 h. When compared with other international standards the biodiesel produced was found to be within the limits of the specification by ASTM D6751 (American standard), EN 14241 (European Standard) and Ghana Standard Authority. It was therefore recommended that biodiesel from Parkia biglobosa seed oil under acidic catalytic condition is a potential new non-edible substitute for petroleum diesel for commercialization purposes.
Synthesis and photoluminescence properties of Ce3+ and Tb3+ doped Na3Gd(PO4)2 phosphors for white LEDs
Authors: Xie Meiling , Fang Minghao , Huang Zhaohui , Liu Yan’gai , Wu Xiaowen , Min Xin
Published: February 2023

In this paper, Na3Gd(PO4)2 phosphors, doped with rare-earth metal ions Ce3+ and Tb3+ were fabricated by the solid-state reaction method. Under the excitation of 340 nm light, the Ce3+-doped Na3Gd(PO4)2 phosphors exhibit a broad emission band ranging from 370 nm to 480 nm, which emitted bule light centered at 405 nm. When excited at 373 nm, the Tb3+-doped Na3Gd(PO4)2 phosphors presented a green light emission, including a strong peak at 547 nm. In addition, both of the Na3Gd(PO4)2: Ce3+ and Na3Gd(PO4)2: Tb3+ phosphors showed excellent thermal stability at different temperatures, of which the emission intensities at 150°C could maintain about 84% and 92.9% of those at room temperature, respectively. A prototype of the white light-emitting diodes lamp exhibiting bright white light was fabricated by using a 365 nm near-ultraviolet-emitting LED chip, combined with Na3Gd(PO4)2: Ce3+ blue phosphors, Na3Gd(PO4)2: Tb3+ green phosphors, and Na3Gd(PO4)2: Eu3+ red phosphor, which produced a high color rendering index of 89.4, and a relatively low correlated color temperature of 5496 K. Moreover, the CIE point is calculated to be at (0.3332, 0.3438), locating in the white light region. These results indicate that the as-prepared phosphors can be considered as potential candidates for ultraviolet/near-ultraviolet light-excited white light-emitting diodes applications.
Regulations of hydrophilicity of cellulosic nanosheets by polarity of coagulation bath
Authors: Li Lvgang , Huang Fei , Guo Yifan , Wang Jiahao , Zhang He , Zeng Rong , Zhou Zuowan
Published: February 2023

Regeneration from cellulose solution is an effective way for processing and regulating the cellulose-based materials, during which the coagulation bath plays an important role that has been paid insufficient attention. Herein, we investigate the effect of polarity of the coagulation baths on the hydrophilicity of the regenerated cellulose, and the results show that polarity of the coagulation bath affects the crystalline assembly along different crystal plane by regulating the molecular interactions, leading to discriminating surfaces of hydrophilicity. Strong-polar coagulation bath, such as H2O, induces the regeneration of cellulosic molecules along 11¯0 crystal plane, leading to form hydrophilic nanosheets. Lowering the polarity of the coagulation baths results in fragmenting the morphology and reducing the hydrophilicity of the nanosheets that regenerate along the 110 or 020 crystal planes. Molecular dynamics simulations reveal the mechanisms for the interactions between the polar groups in cellulosic molecules and the hydrophilic facet of the regenerated cellulose. During the regeneration process, the cellulosic molecules are assembled under the influence of van der Waals interactions, resulting in crystallizing along the direction of 110 face to form the two-dimensional nanosheets. As the polarity of the coagulation bath changes from strong to weak, the assembly regeneration evolves from along 11¯0 to 110 or 020 crystal planes, which is recognized by the interaction changing from Van der Waals to hydrogen bond in cellulosic chains. As a result, the cellulose regenerates two-dimensional nanosheets with different hydrophilicity on the surface. The experimental and calculating results provide the feasibility for structural regulation of regenerated cellulosic materials with demand performance of different hydrophilicity.
Efficacy of the Addition of Robot-assisted Radical Cystectomy with Extracorporeal Urinary Diversion after an Enhanced Recovery Protocol
Authors: Nagayama Jun , Yamamoto Akiyuki , Naito Yushi , Kamikawa Hiroki , Kanazawa Hideyuki , Asano Akiyuki , Sho Norie , Terashima Yasuhiro
Published: February 2023

Background: Evaluation of the benefits to postoperative outcomes of introducing robot-assisted radical cystectomy (RARC) to enhanced recovery after surgery (ERAS) is limited, especially in RARC with extracorporeal urinary diversion (eRARC). We assessed whether eRARC, when added to ERAS, provided additional efficacy in terms of patient outcomes during its initial implementation.
Methods: We retrospectively identified 143 patients undergoing radical cystectomy with urinary diversion between June 2010 and December 2021 at a single center. The patients were assigned to three groups based on the type of surgical procedures and perioperative recovery protocols used. Length of hospital stay (LOS) and 90-day postoperative complication rates were compared between the groups. Regression analyses were performed to evaluate how ERAS and eRARC affected outcomes. Whereas, multivariate analysis was used to detect LOS predictors.
Results: The median LOS was shorter with ERAS and eRARC (28.0 vs. 20.0 vs. 17.0 days, P < 0.001). In the linear regression model, ERAS was associated with a significantly shorter LOS (10.4 days, P < 0.001); eRARC was also associated with a shorter LOS, but the difference was nonsignificant (4.10 days, P = 0.14). Neither ERAS nor eRARC was associated with a significant improvement in complications. Following multivariate analysis, ERAS was found to be independently associated with shorter LOS (OR 0.23, P < 0.001), but eRARC showed no such association (OR 0.29, P = 0.096).
Conclusion: ERAS was significantly associated with shorter LOS. Although a desirable trend was evident, eRARC did not contribute to additional efficacy. Neither ERAS nor eRARC improved complications.
Psychotic vulnerability and its associations with clinical characteristics in children and adolescents with Obsessive-Compulsive Disorder
Authors: Borrelli Davide Fausto , Cervin Matti , Ottoni Rebecca , Marchesi Carlo , Tonna Matteo
Published: February 2023

Compared to peers, children, and adolescents with Obsessive-Compulsive Disorder (OCD) are at increased risk of developing psychotic disorders. Yet very few studies have examined early indicators of psychosis in pediatric OCD. In the present study, 52 pediatric outpatients (mean age = 15.66 [SD = 2.33], 59.6% girls) with a primary diagnosis of OCD were interviewed using the Schizophrenia Proneness Instrument Child and Adolescent version (SPI-CY), which is a comprehensive clinical interview assessing both Cognitive–Perceptual basic symptoms (COPER) and high-risk criterion Cognitive Disturbances (COGDIS). Associations between COPER/COGDIS symptoms and demographic and clinical characteristics were examined. COPER or COGDIS symptoms were present in 44% of participants, with no significant difference in frequency between girls and boys. Psychotic vulnerability was associated with an earlier age of OCD onset, greater OCD severity, and poorer insight. Further, it was strongly associated with worse psychosocial functioning and explained 22% of unique variance in this variable. Findings suggest that early indicators of psychosis are frequent in pediatric OCD and associated with more severe OCD and poorer functioning. Research examining how psychotic vulnerability in pediatric OCD is associated with short- and long-term outcome is needed.
Frontiers and Emerging Trends in Cardiorenal Syndrome biomarker: A Bibliometric and Visualized Analysis from 2003 to 2022
Authors: Mao Xinxin , Zheng Haoran , Fu Zhenyue , Lv Jiayu , Shi Shuqing , Xu Xia , Wang Yajiao , Li Yumeng , Zhang Bingxuan , Wu Huaqin , Song Qingqiao
Published: February 2023

Background: Since the term of Cardiorenal syndrome (CRS) was proposed, the field has attracted much attention, and research on biomarkers of CRS has gradually emerged. Now, many CRS biomarkers have been identified and applied in clinical practice for disease diagnosis, treatment guidance, prognosis prediction and so on. In this study, bibliometrics was used to analyze the current status, research hotspots and frontiers of CRS biomarkers, in order to provide some valuable information for the research in this field.
Methods: Literature related to CRS biomarkers in the Web of Science database from 2003 to 2022 was searched. Based on CiteSpace, Vosviewer software and R program, the bibliometrics method was adopted to conduct quantitative retrospective analysis, visual presentation and result interpretation of the included literatures.
Results: A total of 577 literatures related to CRS biomarkers were included.Since the study was carried out, the number of published papers has been on the rise. The United States dominates the field; The San Bortolo Hosp's publication ranks first; Claudio Ronco is the most influential author in the field, with an absolute advantage in the number of publications and citations. CARDIORENAL MEDICINE (IF=4.36) is the most published journal focusing on CRS research.Finally, the biomarkers and research hotspots of CRS are introduced.
Conclusion: The exploration of new biomarkers is still a hotspot in this field, and their value in efficacy and prognosis is a potential research direction. Exploring the mechanism of disease and pathophysiology may be the forefront of research in this field in the future.
Effects of high intensity and progressive volume resistance training on functional, mental states, and quality of life of people with spinal cord injury
Authors: Rodrigues Joel Alves , Torres Eveline , Pereira Jaqueline Salgado Lopes , Teixeira Robson Bonoto , Silva Sandro Fernandes da , Aidar Felipe José , de Oliveira Cláudia Eliza Patrocínio , Encarnação Samuel Gonçalves Almeida da , Forte Pedro , Teixeira José Eduardo , Monteiro António Miguel de Barros , Moreira Osvaldo Costa
Published: February 2023

Objective: To establish the effect of high intensity and progressive volume resistance training (HIRT), on general health, functional, mental status, and quality of life (QOL) indicators in people with spinal cord injury (SCI). Methods: The sample consisted of 5 people with SCI of both sexes, aged 46.2 ± 13.9 years, submitted to 12 weeks of HIRT, twice a week. Were analyzed before and after the 12 weeks of intervention: body composition, muscle strength, functional status, perception of mental status, and QOL, using the following tests: dual-energy x-ray densitometry, 1RM, isometry of biceps, elbow flexion, Wingate, zigzag, medicine ball pitch, Beck inventory (anxiety, depression and mental disorder) and SF-36. Results: The results pointed to an increase in the training load, the total bone mineral content (p= 0.043), the muscle power at 80% of 1RM (p = 0.043), the functional state (anaerobic power [= 6,81%; p= 0.043] and explosive strength [= 30,57%; p= 0.043] of the shoulder girdle muscles), the mental state (= 71,46%; p= 0.006) and finally, improvement in QOL, especially in the functional (= 60,87%; p= 0.006) and social aspects (= 44,44%; p= 0.006). Conclusions: HIRT can improve or maintain body composition, developing muscle power, anaerobic power, and explosive strength of the upper limbs that will impact functional capacity, promoting greater autonomy, with consequent reflex in improving mental state and of the QOL of the person with SCI.
Advertising In The Transcarpathian Newspaper «Ukrainske Slovo» 1932–1938
Authors: Barchan Olesia
Published: February 2023

Introduction. The advertising industry of Transcarpathia in the 1930s of the 20th century was closely connected with the economy of Czechoslovakia, to which this territory belonged from 1919 to 1939. Advertising in the Ukrainian-language newspaper «Ukrainske Slovo» (1932–1938) represents social, political, and commercial relations, and gives an idea of the advertising management of the editorial office.
Relevance of the study. The relevance of the topic is due to the fact that the place and role of the Transcarpathian press of the 20–30s of the 20th century in the formation and development of the advertising market are largely unexplored, in particular, the Ukrainian- language newspaper «Ukrainske Slovo». The purpose of our work is to analyze the activities of the socio-political newspaper «Ukrainske Slovo» concerning the formation and promotion of advertising content and research the factors of the development of the advertising sphere in the region at that time.
Methodology. The research is based on the principles of systematic, historical-comparative, descriptive-analytical, problem-chronological scientific methods that provide an opportunity to highlight this aspect of the informational activity of the newspaper «Ukrainske Slovo» conceptually.
Results. In the process of work, it was found that the publishers of the newspaper «The Ukrainian Word» developed professional advertising management. Publishers used a variety of formal-graphic and psychological-motivational methods of attracting readers’ attention, used textual methods of influence, and implemented social and hidden advertising. In the context of the general advertising management of the editorial office, active work with advertisers and consumers was observed.
Conclusions. For the first time the analysis of the advertising content of Transcarpathian periodicals of the 20–30s of the 20th century, in particular the newspaper «Ukrainske Slovo» (1932–1938), was carried out. The concept of the advertising information of this newspaper is seen clearly and it lies in the creation of effective communication between the production and consumer spheres, and at the same time in the successful implementation of the idea of Ukrainian national unity on an economic basis.
DENTAL TREATMENT OF A CHILD SUFFERING FROM TMJ ANKYLOSIS UNDER GENERAL ANESTHESIA: A CASE REPORT
Authors:   Heeya Pediatric Dental Clinic Gurukul Road. - 380052., Modh Daivik , Modi Sachin ,   Heeya Pediatric Dental Clinic Gurukul Road. - 380052., Shah Pathik ,   Heeya Pediatric Dental Clinic Gurukul Road. - 380052., Reshamwala Hetasvi ,   Heeya Pediatric Dental Clinic Gurukul Road. - 380052.
Published: February 2023

Temporomandibular joint (TMJ) ankylosis is a joint disorder which refers to bone adhesion of the anatomic joint components, resulting in loss of function [1]. The etiologies of TMJ ankylosis include previous trauma, previous TMJ surgery, arthritis, and infection. It can be congenital, and in some cases, idiopathic. The most common etiology of TMJ ankylosis is previous trauma, with the second being infection [2].
A CASE REPORT OF MIGRATORY FISH BONE PIERCING LEFT LOBE OF THE THYROID
Authors:   Internal Medicine Unit/Gastroenterology, Hatta Hospital, Dubai, United Arab Emirates., Khaled Abou El. Foul Rami , Gomah Hamed Alaqqad Mohamed ,   General Surgery Department, Hatta Hospital, Dubai, United Arab Emirates., Mahmoud Ibrahim Mohamed Mohamed ,   Radiology Department, Hatta Hospital, Dubai, United Arab Emirates., Abdulmola Albawab Amer ,   Radiology Department, Hatta Hospital, Dubai, United Arab Emirates., Ram Leela ,   General Surgery Department, Hatta Hospital, Dubai, United Arab Emirates., Intesar Mehdi Kazmi Syed ,   General Surgery Department, Hatta Hospital, Dubai, United Arab Emirates., El Fatih Mohammed Ibrahim Khalid ,   Radiology Department, Hatta Hospital, Dubai, United Arab Emirates., Samir Mokhtar Hamed Elwan Mohammed ,   Radiology Department, Hatta Hospital, Dubai, United Arab Emirates., Mohamed Refat Elhefni Tarek ,   Anesthesia Department, Hatta Hospital, Dubai, United Arab Emirates., Syed Rezzek Manal ,   Anesthesia Department, Hatta Hospital, Dubai, United Arab Emirates.
Published: February 2023

Fish bone as a foreign body in the throat is common and frequently seen in emergency departments. In most cases, the bone is stuck in the tonsils or oropharynx, some go further to the laryngopharynx, and in rare cases they may go furthest. The authors report a rare case of a fish bone that migrated to the thyroid gland [1, 13&14] Fish bones as swallowed foreign bodies can be managed by direct removal using headlight or require an endoscopic approach. Some even need open surgery. Some bones may penetrate the mucosa of the upper aerodigestive tract and migrate to neck soft tissues and organs. In such cases, patient complaints are of unusual presentation for swallowed foreign bodies, and patients may suffer different complications that require a more aggressive management [2].
SURGICAL HOT TELEPHONE CLINIC: A SAFE ALTERNATIVE TO FACE-TO-FACE HOT CLINIC
Authors: Patel Sima , Osunlusi Oluwafemi
Published: February 2023

Introduction: With increasing patients presenting to the accident and emergency department, the use of virtual clinics has shown promising results in medicine to help safely review these patients while avoiding admissions. These clinics often use the same staff and resources being utilised by theemergencyadmission team â€“ this is especially true in the surgical admissions unit. We present data showing that Virtual Clinics (VC) are safe alternatives, improving patient service and relieving a significant burden on the acute surgical units. Method: Baseline assessment of the virtual clinic was carried out over a 4-week period, between 23rd December 2020 and 19th January 2021. The virtual clinic reviewed 78 patients within this 4-week time period. Parameters for data collection included admission dates, scan date, call-backs, diagnosis, referral patterns, readmission rates and eventual outcomes for those who needed surgical interventions. Reassessment of practise was undertaken in August 2021 following the introduction of a registrar led electronic virtual clinic. Results: Assessment of practice showed that 83% of assessed patients had radiological imaging within 72hours with 89.7% of these scans having reports generated on the same day. Following incorporation of an electronic virtual clinic, 112 patients were reviewed over a 4-week period. Results showed a similar trend in terms of frequency of scans requested with zero failed discharges from the service. Conclusion: The virtual clinic provides a safe and efficient method for the review and management of ambulatory patients in whom semi- urgent investigation is needed but admission is not necessary.
ULTRASOUND-GUIDED FINE-NEEDLE ASPIRATION CYTOLOGY IN GALL BLADDER LESIONS: A RETROSPECTIVE STUDY IN TERTIARY CARE CENTER
Authors: Shankar Meenakshi , Singh Mukul , Gautum Akansha
Published: February 2023

Gallbladder carcinoma is the one of the most common malignancy, comprising of 80â€“95% of biliary tract cancers. Ultrasonography-guided fine-needle aspiration cytology (USG-FNAC) seems to an effective diagnostic the tool for the accurate diagnosis of gallbladder lesions, however data on its diagnostic utility and cyto-morphological categorization of gallbladder lesions are still lacking. Aims: To study the diagnostic usefulness of USG-FNAC in gallbladder lesions. Materials and Methods: This is retrospective study, done in tertiary health care center in which USG FNC diagnoses were correlated with histo-pathological and clinical follow-up, to assess the diagnostic accuracy. A total of 104 USG -FNCs that were performed between 1st of January 2018 to 31st of March 2022 were reviewed. Results: Out of 105 cases, n=21 cases (10.5%) were -inadequate/non-diagnostic.The mean age was 52 years, with a range of 44â€“78 years. Women predominated over men (Male:Female=1:2). Primary adenocarcinoma of the gallbladder was most common. On cyto-histological correlation, the sensitivity, specificity, and diagnostic accuracy of USG-FNAC of gallbladder lesions were found to be 97.82, 89.23, and 98.31%, respectively. Conclusion:USG FNAC techniques ensures satisfactory diagnostic accuracy specially in malignant conditions of gallbladder lesion. Other advantages are such as minimum invasiveness, rapidity, and cost effectiveness. Hence, helps in appropriate management of patients thus avoiding unnecessary morbid surgeries.
INFLUENCE OF HOST PLANTS ON THE AGE-SPECIFICLIFE HISTORY TRAITS OF PARASITOID TRICHOGRAMMA CHILONIS (ISHII) A BIO-CONTROL AGENT OF THE LEPIDOPTERAN PEST HELICOVERPA ARMIGERA (LEPIDOPTERA: NOCTUIDAE) EGG DENSITIES
Authors:   Department of Zoology, D.A.V. Post Graduate College, Gorakhpur., Kumar Pandey Amrendra , Bhaskar Mishra Bhuwan ,   University Department of Zoology, B.N. Mandal University, Madhepura, Bihar.
Published: February 2023

The pod borer, Helicoverpa armigera (HÃ¼bner) (Lepidoptera: Noctuidae), is considered to be the most important pest in several crops such as chick pea (Cicer arietinum L.), Pigeon pea (Cajanus cajan L.) and Tomato (Lycopersicum esculentum L.) in North-East Uttar Pradesh, India. Extensive and indiscriminate use of chemical insecticides against pest caused severe effect on both soil health and environment, therefore effective bio-control agent (BCA), is generally perceived as providing both long-lasting insect pest control and negligible damage to the environment and non-target organisms. The aim of the present study is to control the pest population of H. armigera at Gorakhpur district by using effective bio-control agent. The age-specific life-table statistics of the parasitoid were observed at five different host densities (10, 25, 50, 100 and 200 eggs/female/day). It was found that the values of age-specific survival rate (lx) of T. chilonis increased progressively when more and more host eggs exposed to the female parasitoid throughout their life-span. It was highest at 200 host-density for all the host plants. The age-specific net fecundity rate (mx) was found to be host densities dependent. It appears that at low host density egg laying tendency of the female compel her to lay eggs in a previously parasitised egg. The longevity of the female were significantly (P < 0.001) correlated with host density. The data obtained from the present study will used in the development of management strategies for the control of H. armigera on host crops.
NEUTROPHIL-LYMPHOCYTE RATIO AS A PROGNOSTIC INDICATOR IN DENGUE FEVER PATIENTS AT TERTIARY CARE HOSPITAL IN NORTHWEST-MAHARASHTRA
Authors:   Junior Resident, Department of General Medicine, SMBT IMS & RC, Dhamangaon, Igatpuri, Nashik, Maharashtra., Sadgir Anirudha , Durge Khushal ,   Junior Resident, Department of General Medicine, SMBT IMS & RC, Dhamangaon, Igatpuri, Nashik, Maharashtra., Masavkar Satish ,   Professor and HOU, Department of General Medicine, SMBT IMS & RC, Dhamangaon, Igatpuri, Nashik, Maharashtra.
Published: February 2023

Introduction- Dengue is regarded as the most important arthropod-borne viral infection in humans and is the second most important re-emerging tropical disease. Dengue infections are increasing resulting in more illness and death and in 2012 World Health Organization (WHO) reclassified dengue as the most important mosquito-borne viral disease in the world. Given the heterogeneous nature of the clinical presentation of dengue, identifying robust and sensitive clinical or laboratory predictors of dengue fever and its severity has not been an easy task. Neutrophil-to-lymphocyte ratio (NLR) can be easily calculated based on a complete blood count by dividing the Neutrophil percentage by Lymphocyte percentage. There is enough literature to suggest that NLR has prognostic significance in various diseases. However, no studies have focussed on NLR as a prognostic marker for dengue. Aim- To study NLR in dengue patients and assess its role in relation with age, gender,serological tests for dengue and platelet count. Materials and Methods- This retrospective observational study was carried out at Tertiary care hospital in Northwest Maharashtra. 100 diagnosed and admitted cases of dengue were included in this study. Clinical data and laboratory data were reviewed and analysed. Chi Square test was done and its significance noted. Results- In our study, Ns1Ag dengue serology test was found to be more common in males indicating recent infection and Ns1Ag, IgM and IgG more common in females indicating recent and past infection. NLR < 2 strongly correlates with low platelets indicating severity of disease and reversal of NLR > 2 correlates with improvement of disease. NLR < 2 was more common in 0-20 years age group, younger the age lesser the NLR and hence more severe the disease. Conclusion- From our study we found that there is a significant relation between NLR to the severity of dengue fever in adult patients and by keeping an eye on the NLR we can predict the prognosis and the severity of the disease in patient. Lower the NLR ratio severe the disease. Hence NLR can be used as a prognostic indicator in dengue patients.
ANALYSIS OF PLANE CRASH IN NIGERIA AND LESSONS LEARNED FROM SPECIFIC DISASTER: DANA AIR 0992, 5N-RAM CRASH
Authors: Chinweuba Elele Geoffrey , Akachi Elele Ugochukwu
Published: February 2023

Modern society continues to depend heavily on the wealth and services generated by highly automated and mechanised systems. Therefore, physical assets, including manual and automated systems, must be directed and safeguarded. When these assets fail, life, property, credibility, and trust are typically lost. In the face of rapidly changing technology and maintenance philosophies, one way to avoid failures and catastrophes is to learn from past failures and implement the lessons or recommendations derived from such analyses and reports. Nigeria, like other nations, has experienced disasters caused by asset failures in businesses, factories, and residences.Consequently, the purpose of this article is to raise public awareness and alarm regarding the repercussions of the Nigerian aviation industrys failure to learn from past failures and disasters. As a case study, it employs a documented Dana Air aircraft accident report. In addition, it employs Fault Tree Analysis (FTA), a deductive failure technique, and Reliability Block Diagram (RBD) to gain a deeper understanding of the aircraft accident and its root causes. As a result, a feedback loop is established for the development of additional ideas and actions to prevent future disasters in Nigeria.
A simple approach to fabricate protective coatings on the surface of AZ91 alloy and its corrosion resistance
Authors: Wang Bo , Zuo Fengguang , Bai Dixing , Yang Yingchen , Li Cheng , Zhang Jumei
Published: February 2023

In this paper, the corrosion resistant coatings were fabricated on AZ91 Mg alloy by steam treatment using deionized water as a steam source. The treatment temperature was maintained at 150 ℃, while the treatment time was varied at 3, 6 and 9 h. The results showed that relatively dense steam coating can be formed on the surface of AZ91 alloy by steam treatment for 3-9 h, and the phase structure of steam coating was mainly composed of Mg(OH)2 and contained AlO(OH) and Mg-Al LDH. With the extension of the steam treatment time, the better the corrosion resistance of the steam coating, and the corrosion current density was as low as 10-7~10-8 A·cm-2, which was 3-4 orders of magnitude lower than AZ91 Mg alloy substrate (~10-4 A·cm-2).
Finite element analysis of the influence of ice temperature expansion force on surface water quality monitoring system
Authors: Jiang Jiguang , Li Xiaotian , Su Chengzhi , Guo Xuanji , He Mingzhibo , Zeng Yue
Published: February 2023

Ice will form in winter in high-latitude areas of China. As the external temperature rises, the ice cover will generate thermal expansion force on the restrained object. Based on the single-factor sensitivity method, the thermal solid coupling model is used to calculate the ice layer thermal stress. The intensity of the water quality monitoring system in China's high latitude icing period is modeled and calculated. The results show that with the increase of the external temperature rise rate, the external initial temperature decreases and the thickness of the ice layer increases, the expansion force of the ice layer temperature increases, and the stress field of the ice layer presents nonlinear distribution. The extreme point is located at 1/3 of the ice layer thickness. The water quality monitoring system will produce high stress at the edge of the body, which should be paid attention to when it is concentrated on engineering use.
Study on the performance of fuel cell air filter with different carbon content
Authors: Bian Jiachen , Wei Shuhong , Jiao Pengfei , Bian Kun , Fu Xiaokun
Published: February 2023

Fuel cell air filter can absorb harmful impurities and gases to fuel cell and is an important component to ensure the service life of fuel cell. The previous researches mainly focus on the activated carbon and filter paper materials in the laboratory. The object of this paper is the fuel cell air filter product assembly being used by the main engine plant. According to the tests of air filters with different carbon contents, it was found that the adsorption efficiency of current products for NO2 was better than that of C7H8, SO2 and C4H10. Based on the adsorption mechanism of activated carbon for different gases, the adsorption difference was explained. The testes also found that there was no direct relationship between the change of carbon content of products containing activated carbon and the fractional filtration efficiency. The main reason is that the gap between the activated carbon particles is large, which cannot effectively intercept dust particles. The filtering of small size particles still depends on the melt-blown layer material in the air filter element and its electrostatic electret process. It was also found that there was a positive correlation between inlet air resistance and carbon content, and a negative correlation between dust holding capacity and carbon content. This test results can help the main engine factory understand the performance and improvement direction of products.