bluuebunny/crossref_metadata_2025 huggingface dataset:
Administrative and Legal Implementation of the Rights of Business Entities
Authors: YESIMOV SERHII , BOROVIKOVA VITALINA
Published: December 2022

The study considers theoretical and practical aspects of the administrative and legal implementation of the rights of business entities based on the current legislation and regulatory requirements of the European Union from the perspective of the modern theory of state and law and administrative law. The relevance of the subject matter is conditioned by the need to improve legislation for the purpose of a comprehensive theoretical substantiation for improving the efficiency of the implementation of rights by business entities in the context of the transformation of the Ukrainian economy. The purpose of the study is to investigate the implementation of the rights of business entities. The study applied the methodology of a systematic comprehensive analysis of legal phenomena using factor and evolutionary research methods. It is indicated that the activities of public administration bodies have public legal goals (law enforcement, regulatory, fiscal, and accounting). One of the activities of public administration bodies is to ensure the implementation of the rights of business entities. The specific features of administrative and legal implementation of business rights by public administration bodies are considered. It is indicated that this activity is implemented by issuing individual administrative legal acts or performing certain administrative actions. Implementation methods (registration, licensing procedures, certification, and accreditation) are considered. The content of technical regulation is disclosed, including the development and adoption of technical regulations, rules, standardisation, conformity assessment, quotas. The role and significance of state supervision and control in the sphere of entrepreneurial activity as a way of administrative and legal support for the implementation of the rights of business entities is substantiated. The role of administrative procedure law and administrative procedure for the administrative and legal implementation of the rights of business entities is indicated. The study is aimed at improving the norms of administrative law regarding the implementation of the rights of business entities.
State Guarantees for the Establishment of a Monthly Long-Service Allowance of Academic Staff to a Police Officer Seconded to a Higher Education Institution with Specific Training Conditions to Ensure the Educational Process
Authors: KONDRATІUK ОLEKSANDR
Published: December 2022

The selective establishment of an allowance for pedagogical workers, depending on the subordination and type of educational institution in Ukraine, is a discriminatory attitude towards a certain category of persons who, having the appropriate scientific or teaching experience, provide the educational process without receiving state-guaranteed allowances for this. The study reveals the problem of violation of the right of pedagogical workers among police officers serving in institutions of higher education with specific training conditions to receive allowances for the length of service of an academic worker. It is established that such a supplement is not charged at all to police officers who carry out pedagogical and academic activities in higher education institutions of the Ministry of Internal Affairs of Ukraine. The purpose of the study is to substantiate the legality of establishing and mandatory payment of scientific surcharges to police officers sent to educational institutions to ensure the educational process. The key methods of research are systematic and structural analysis, which allowed generalising and analysing bylaws, legislative and departmental regulations on the establishment of a long-service allowance for an academic worker to persons involved in ensuring the educational process in educational institutions with double subordination. It is proved that the state guarantee regarding the obligation to establish a long-service allowance for an academic worker, which is provided for by the laws of Ukraine, applies to police officers who are sent to higher educational institutions for service in the positions of educational workers. It is proved that in relation to such police officers, it is the legislative provisions that are special, and not the provisions of bylaws, and therefore, bylaws cannot be applied in case of competition of legal norms. The implementation of legislative and departmental regulations on the state guarantee of the rights of academic workers in terms of calculating the long-service allowance of an academic worker to a police officer sent to a higher education institution for further service as a educational worker and enrolment in the teaching experience of a police officer of periods of work in the positions of pedagogical and academic workers would lead to the expected economic effect, namely, an increase in its monetary support by approximately 10-30% of the official salary established by the educational institution.
Analisis Penggunaan Sarana Sistem Pembuangan Air Limbah di Rumah Penduduk Desa Terusan Kabupaten OKU Tahun 2021
Authors: A Ansori , AD Akhmad Dwiprayetno , CZ Chairil Zaman
Published: December 2022

The problem of environmental health is one of the problems that needs to be prioritized. Land ownership is to find out the criteria for the house to meet the requirements of a healthy house including knowing whether it has available land to allow it to build a simple sewerage channel, to build a simple sewerage channel and the level of community income and community knowledge, and whether or not it is able to construct a simple sewerage. This study uses a Cross Sectional design to determine environmental factors related to SPAL ownership. The population of this study was all KK in the village of Canal in the working area of ??UPTD Puskesmas Sekar Jaya and the sample of this study was 191 samples. Data were analyzed using Chi-Square statistical test. From the results of the study, it was found that the frequency distribution of respondents who have SPAL ownership available is 39.3%, while those who are not available are 60.7%, in the category of land availability there are 36.6% and no 63.4%, good knowledge 77.0% , and not good 23.0%, high income 35.6% and low income 64.4%. The conclusion of this study is that there is a significant relationship between land availability and SPAL ownership with a P-Value of 0.001 , there is no significant relationship between knowledge and ownership of SPAL with a P-Value of 0.008 , there is a significant relationship between income and SPAL ownership with a P-Value of 0.000.
Faktor Risiko Kejadian Stunting Pada Anak Balita Usia 24 – 59 Bulan di Wilayah Kerja Puskesmas Penyandingan Kabupaten OKU Tahun 2021
Authors: DE Diana Estherina , EG Erma Gustina , Y Yusnilasari
Published: December 2022

Stunting is still a problem in terms of nutrition and child development in Indonesia. Stunting in the province of South Sumatra in 20 18 amounted to 31.7 %. The prevalence of stunting in OKU Regency is 33.2%. The highest contributor to the stunting rate was the Pairing Health Center with 56 children under five. The purpose general of the research it is  factor factors related to the incidence of stunting . This study is a correlation with case control design using secondary data from the MCH book and primary data through interviews. Variables examined included height toddler , the type of sex, the provision of breastfeeding , maternal education level, breastfeeding Eksklusif and birth weight. The number of samples in this study were 1 1 2 samples which included 56 case groups and 56 control groups. The sampling technique for the case group used a saturated sample and the probability sampling technique was used for the control group . The results showed that the variables related to the incidence of stunting were birth weight under five with p-value 0.073, giving MP-ASI p-value 0.342, exclusive breastfeeding p-value 0.095 and mother's education p-value 0.433. It is recommended to the puskesmas and related parties to increase the provision of information and socialization to the public about stunting and how to reduce the incidence of stunting in children under five.
Analisis Pemberian ASI Eksklusif oleh Ibu Menyusui di Puskesmas Tanjung Agung Kabupaten OKU
Authors: DN Desiana Nafisa , CZ Chairil Zaman , HES Helen Evelina Siringoringo
Published: December 2022

Health is a human right and one of the elements of welfare that must be realized. One of them is that every baby has the right to get exclusive breast milk from birth for 6 (six) months. The purpose of this study was to look at the factors associated with patient satisfaction. This study uses a quantitative method with a Cross Sectional approach. Statistical test using Chi Square test. Multivariate analysis in this study used multiple logistic regression analysis. In this study, it can be concluded that there is no relationship between age (p = 0.583), knowledge (p = 0.065), information exposure with exclusive breastfeeding at the Tanjung Agung Health Center, OKU Regency in 2021 (p = 0.051). There is a relationship between education (p = 0.036; OR = 3.734), occupation (p = 0.029; OR = 2.884), parity (p = 0.030; OR = 3.128), family support (p = 0.033; OR = 2.899) and support for health workers (p = 0.044; OR = 0.364) with exclusive breastfeeding at the Tanjung Agung Health Center, OKU Regency in 2021. The most dominant variable is education (p = 0.005; OR = 8.385). The findings of this study can be used by health centers, especially in OKU Regency so that respondents can educate respondents to provide input so that they want to give exclusive breastfeeding
Analisis Faktor Risiko Kejadian Hipertensi di Puskesmas Lubuk Batang Wilayah Kerja Dinas Kesehatan Kabupaten OKU Tahun 2021
Authors: EP Evita Puryanti , EG Erma Gustina , Y Yusnilasari
Published: December 2022

Hypertension is a disease that is still a concern of all circles of society, because of the impact that can be caused by hypertension in the short and long term. The OKU District Health Office showed that hypertension was the 10th largest disease and the highest number of diseases was 20,000 cases. The purpose of this study was to analyze the risk factors associated with the incidence of hypertension. The study was carried out on April 1, 2021 to June 1, 2021 at the Lubuk Batang Health Center in the Work Area of ??the OKU District Health Office in 2021. The research design will use a quantitative method with a cross sectional design. The sample of this study amounted to 100 people who were patients who came for treatment at the Lubuk Batang Health Center at the time of the study. The results of the study on bivariate analysis obtained p values ??for age (0.038), gender (0.153), occupation (0.200), exercise (1,000), family history of disease (1,000), smoking (0.582). In the multivariate analysis, the age variable was obtained with a p value of 0.188. There is a significant relationship between age and the incidence of hypertension and there is no relationship between gender, occupation, exercise and family disease with the incidence of hypertension.
Review on Importance of Freshwater Invertebrates on Birds Feeding
Authors: Mahesh Jadhav  , Rajesh Achegawe  , Shivaji Chavan
Published: December 2022

Macroinvertebrates are a significant class of creatures that are located in the sediment that lies below the water column and are essential to the health of any aquatic environment. Their research is crucial because, as a result of their sedentary habitat, macrobenthic organisms are well-known markers of anthropogenic stress. Freshwater invertebrates are not only a source of protein but also a link in the aquatic food chain and an indication of the health of the aquatic ecosystem. Freshwater invertebrates are food for a variety of fish, birds, and other aquatic organisms, they play a crucial role in the circulation and recirculation of nutrients in aquatic ecosystems by accelerating the breakdown of decaying organic matter into simpler inorganic forms. Benthic fauna also contributes significantly to the food chain for higher animal taxa by transmitting energy and matter from phytoplankton, zooplankton, and macrophytes to fish, amphibians, reptiles, birds, and mammals as they serve as key food sources for them.
Logopädie Intervention bei Patienten mit diagnostizierter Aufmerksamkeitsdefizit-Hyperaktivitätsstörung: Integrative Überprüfung
Authors: Silva Fagner Pereira da
Published: December 2022

Die Aufmerksamkeitsdefizit-Hyperaktivitätsstörung (ADHS) kann als neurobiologische Störung mit genetischen Ursachen charakterisiert werden, die unter den Hauptsymptomen Unaufmerksamkeit, unruhiges Verhalten sowie Impulsivitätsprobleme aufweist. Diese Störung tritt in der Kindheit auf und kann den Menschen sein ganzes Leben lang begleiten. Die Behandlung kann durch die Kombination von Medikamenten, Psychotherapie und Logopädie erfolgen, insbesondere wenn Sprachstörungen oder Schreibprobleme beobachtet werden. In diesem Zusammenhang hat der vorliegende Artikel die Leitfrage: Wie kann Logopädie wirken, um die durch die Aufmerksamkeitsdefizit-Hyperaktivitätsstörung verursachten Probleme zu reduzieren? Daher ist das Hauptziel dieser Forschung, anhand der bereits veröffentlichten Literatur die Intervention der Logopädie bei Patienten zu analysieren, bei denen eine Aufmerksamkeitsdefizit-Hyperaktivitätsstörung diagnostiziert wurde. Für die Grundlage der Forschung war es notwendig, eine integrative bibliografische Recherche durchzuführen, bei der mehrere Theorien zur Intervention der Logopädie bei Menschen mit ADHS analysiert wurden. Dazu wurden Recherchen in den Datenbanken: Scielo, Pubmed, Lilacs und Medline durchgeführt. Durch diese Forschung wird der Schluss gezogen, dass die Leistung von Logopäden bei Personen, bei denen ADHS diagnostiziert wurde, zu einer signifikanten Verringerung multipler Verhaltensweisen führt, was erheblich dazu beiträgt, die Hauptschwierigkeiten dieser Personen, wie Aufmerksamkeits- und Impulsivitätsprobleme, zusätzlich zur Unterstützung zu bekämpfen Eltern oder Erziehungsberechtigte von Menschen mit ADHS.
Intervento di logopedia in pazienti con diagnosi di disturbo da deficit di attenzione e iperattività: revisione integrativa
Authors: Silva Fagner Pereira da
Published: December 2022

Il Disturbo da Deficit di Attenzione e Iperattività (ADHD) può essere caratterizzato come un disturbo neurobiologico, con cause genetiche, che presenta, tra i sintomi principali, disattenzione, comportamenti irrequieti, nonché problemi di impulsività. Questo disturbo compare durante l’infanzia e può accompagnare l’uomo durante tutto il suo ciclo di vita. Il trattamento può essere effettuato attraverso l’associazione di farmaci, psicoterapia e logopedia, soprattutto quando si osservano disturbi del linguaggio o problemi di scrittura. In questo contesto, il presente articolo si pone come domanda guida: come può agire la logopedia per ridurre i problemi causati dal disturbo da deficit di attenzione e iperattività? Pertanto, l’obiettivo principale di questa ricerca è analizzare, attraverso la letteratura già pubblicata, l’intervento della logopedia in pazienti con diagnosi di disturbo da deficit di attenzione e iperattività. Per la fondazione della ricerca è stato necessario svolgere una ricerca bibliografica integrativa, analizzando diverse teorie relative all’intervento della logopedia nelle persone con ADHD. Per questo sono state effettuate ricerche nelle banche dati: Scielo, Pubmed, Lilacs e Medline. Si conclude attraverso questa ricerca che le prestazioni dei logopedisti in individui con diagnosi di ADHD forniscono una significativa riduzione dei comportamenti multipli, aiutando in modo significativo per quanto riguarda la lotta alle principali difficoltà di questi individui, come i problemi di attenzione e impulsività, oltre all’assistenza a genitori o tutori di persone con ADHD.
Design thinking: uma ferramenta preventiva contra o mosquito Aedes aegypti em Lorena/SP
Authors: Santos Daniel dos , Souza Adriano José Sorbile de
Published: December 2022

A presente dissertação trata-se de um estudo que consiste em um processo de inserção da ferramenta “Design Thinking”, a qual contribuiu na adoção de estratégias para prevenção e combate do mosquito Aedes aegypti no Bairro da Cruz (Município de Lorena), tendo como objetivo detectar produtos ou serviços que possam gerar protótipos que auxiliarão neste desafio. A metodologia utilizada é caracterizada por uma pesquisa exploratória descritiva e uma pesquisa qualitativa. Além disso, na primeira fase de imersão, criou-se o quadro de post-its (responsável por evidenciar suposições e dúvidas), gerando dois questionários para observar as necessidades da Secretaria de Saúde e da população. Para as informações fornecidas, utilizou-se as ferramentas Brainwriting, responsável por fornecer as ideias, e o Word Cloud, que evidenciou as ideias mais citadas. A partir disso, os resultados obtidos foram a Arte na Rua, a qual foi representada em forma de pintura, e a Oficina nas Escolas, que se utilizou das atividades em sala de aula como veículo de mobilização social e conscientização. Em pesquisa de satisfação, ambas as atividades contribuíram de forma positiva. Dessa forma, concluiu-se que a funcionalidade do design thinking indicou um potencial de inovação, trazendo inúmeras contribuições. Esta nova estratégia viabilizou a implantação de um novo serviço no bairro, conhecido como Projeto Vaza Mosquito, que possibilitará, através de suas atividades, um novo posicionamento de transmitir e reforçar a conscientização, gerando, assim, um aspecto fundamental de estruturação tanto para o bairro quanto para o município.
 Актуальные вопросы патогенетического лечения болезни Фабри в Российской Федерации    S. Moiseev   L.M. Kuzenkova   N.D. Vashakamadse   E.M. Shilov   O.N. Kotenko   T.V. Podkletnova   A.N. Semyachkina   M.S. Harlap

  12 03 2022   11 03 2022   66 68   10.32756/0869-5490-2022-4-66-68 https://clinpharm-journal.ru/articles/2022-4/aktualnye-voprosy-patogeneticheskogo-lecheniya-bolezni-fabri-v-rossijskoj-federatsii/
Macrolide antibiotics: chemical structure, mechanism of action and safety issues
Authors: Skryabina A.A. , Nikiforov V.V. , Shakhmardanov M.Z. , Zastrozhin M.S. , Sychev D.A.
Published: December 2022

The article provides an overview of current publications on the chemical structure, mechanism of action and safety of macrolide antibiotics. We conducted a search in PubMed and Google Scholar databases for the scientific articles published from 2010 to 2021. The following key words were used: macrolides, macrolide antibiotics, erythromycin, clarithromycin, azithromycin, mechanism of action, adverse drug reactions, toxicity. Macrolides are broad-spectrum antibiotics used to treat a wide range of both local and systemic infectious diseases. Macrolides are generally safe, although they can induce certain dose-dependent adverse drug reactions.
Knowledge of Slum-Dwelling Adult Women Regarding Harms of Tobacco Use
Authors: Rahman Protyti , Alam Mohammad Rashidul
Published: December 2022

Background: Tobacco use has become one of the major causes of premature deaths in developing countries including Bangladesh. Incidence of tobacco consumption among the women in developing country is increased day by day. The objective of this study was to assess the knowledge of slum dwelling adult women regarding harms of tobacco use.
Materials & Methods: This descriptive type of cross-sectional study was conducted in selected urban slums of Dhaka North City Corporation from 1st January 2021 to 31st December 2021. Total 300 slum dwelling adult women was selected by convenience sampling technique. Data were collected through face to face interview using a pre-tested semi structured questionnaire.
Results: In the study, the mean age of the respondents was 32 (± 6.96) years where maximum (44.3%) within the age group of 20-29 years. Majorities (97%) of the respondents were muslim and 93.7% were married. Among them 29% women were completed primary education. Most (59.3%) of the respondents were home maker and majority (96.0%) of them were came from nuclear family. The study showed that most (56%) of the respondents consumed smokeless tobacco (Jarda, Sada pata, Gul) and only 1.7% respondents consumed smoking tobacco (bidi). Majority of the women knew that tobacco use can cause different types of cancer but many of them did not know that tobacco use had detrimental effects on reproductive health of women. Television (44.3%) was the main source of the information about harms of tobacco use. The mean knowledge score of the respondents was 7.8 (±2.4). Association between most of the socio-demographic variables and the respondent’s knowledge score regarding harms of tobacco use was found statistically significant (p< 0.05).
Conclusion: This study revealed that the educational levels of most of the slum women were low and they had the lowest mean knowledge score regarding harmful effects of tobacco use. Health educational programs and awareness campaigns should be conducted among slum dwelling women of urban community to increase their knowledge on harmful effects of tobacco use.
JOPSOM 2021; 40(2): 58-64
From the musical history of liberation songs. Problem essays.
Authors:   Mykola Lysenko Lviv National Music Academy, Lukaniuk Bohdan
Published: December 2022

Liberation song is a special genre of mass oral and writing art which expresses the spirit of protest, the people’s struggle against oppression, their rights of freedom, for their social, national, and universal rights, and it is an effective means of orienta- tion and organizing the vast majority of society. Such a song is usually attributed to an author if necessary, and, having become widespread and even often worldwide, it is adopted into folklore. Such songs can also to some extent be modified due to the influence of public artistic thinking. Therefore its theory, history and practice create apparent ethnomusicological research interest. The proposed problem essays discuss the history of five popular Ukrainian (or those of countries closely related to Ukraine) liberation songs – older and newer, both in terms of appearing during the last three centuries (1654–1921), and in musical and poetic style. According to their international significance, their original sources, and the way evolutions are revealed, most are still little known or completely unknown. These mostly debatable attempts to resolve the issues require further studies, which are sure to open more than a few fascinating pages in the country’s past. This issue of “Ethnomusic” includes the following three essays (previously see: [Lukanyuk 2022a]). Keywords: liberation song, Ukraine, primary sources, musical history, ways of evolution.
MİKRO HACİMLİ MUTFAK MEKÂNLARI VE ERGONOMİSİ
Authors: İŞANÇ Defne , GÜNEY YÜKSEL Fatma Ceyda
Published: December 2022

Giderek küçülen konutlar ve minimal bir yaşam anlayışı, mikro hacimli yaşam alanları ve bununla birlikte mikro hacimli mutfak mekânları kavramlarını karşımıza çıkarmaktadır. Mikro hacimli mutfak mekânının verimli kullanılabilmesi için fonksiyonel ve ergonomik çözümlere sahip olması gerekmektedir. Mutfak, konutta sıklıkla kullanılan, mekânın en temel alanlarından biri olarak tanımlanırken, aynı zamanda yerel mimari örnekleri için de ocak ile ilişkilendirildiğinde, yaşam alanının kalbi olarak nitelendirilebilmektedir. Değişen mekân dinamikleri, bireyselliği ön plana çıkarırken artan talepler ve ihtiyaçlarla birlikte mikro hacimli yaşam alanlarına olan ilginin artmasına sebep olmuştur. Yapılan bu çalışmanın ilk bölümünde mutfak ergonomisi açıklanmış devamında ergonomiyle ilişkili donatı elemanları, antropometrik veriler ve çalışma üçgeni açıklanmıştır. İkinci kısımda mikro hacimli mekânlar ve mikro hacimli mutfaklar ile bu mekânlarının fonksiyonel olabilmesi için ürün ve mekân bazlı çözümler geliştirilmiştir. Bu çalışma ile birlikte, küçük mutfak mekânının ergonomik ve mikro hacimli çözümlere sahip olabilmesi için kullanım pratikleri gözlemlenmiş, fotoğraflama yapılarak mevcut durum incelenmiş ve öneriler getirilmiştir.
ORMAN İŞLETME DEPOLARINDA İŞ KAZALARININ ÖNLENMESİ: TEKNİK VE YÖNETSEL ÇÖZÜMLER
Authors: ENGÜR Muvaffak Osman
Published: December 2022

Türkiye’de 243 orman işletmesine ait 467 orman deposu bulunmaktadır. Bu depolar, ormandan gelen odun hammaddesinin depolandığı ve alıcılara satışının gerçekleştirilerek teslim edildiği alanlardır. Yükleme, boşaltma, taşıma ve istifleme gibi işlerin yapıldığı bu alanlarda, hafif ve orta şiddette yaralanmalar yanında ölüm gibi ağır sonuçlu çeşitli kazalar da yaşanabilmektedir. Bu kazaların önemli bir kısmı kamyon veya istif üzerinden düşen/ yuvarlanan odunun çarpması, sıkıştırması ya da araç hareketlerinden kaynaklanan nedenlerle ortaya çıkmaktadır. Odun üretiminin en yüksek olduğu bölgelerde, orman depolarını büyüklük, ağaç türleri, yapılan işler ve ürün çeşitliliği itibariyle temsil edebilecek 5 adet son depoda günlük çalışmalar gözlemlenmiş, drone ve kameralar yardımıyla fotoğraflar ve video kayıtları alınmıştır. Yaklaşık 290 saatlik çekimler ofis ortamında değerlendirilerek, güvensiz koşullar ve hareketlere bağlı sağlık ve güvenlik risklerini azaltmaya yönelik teknik ve yönetsel çözümler sıralanmıştır. Ayrıca farklı bölgelerde yaşanan 6 ölümlü kaza incelendiğinde, risk alanının yükleme veya boşaltma sırasındaki istif – yükleme makinesi – taşıma aracı (kamyon/traktör) üçgeninden oluşan aktif alan olduğu ve ölenlerinde genellikle taşıma araçlarının sürücüleri ve yükleyici işçiler olduğu tespit edilmiştir. Bu çalışmada vurgulanan çözümler, çeşitli orman endüstrisi kuruluşlarına ait odun hammaddesi depolarında da güvenlik performansının yükseltilmesine yardımcı olacaktır.
Non-invasive imaging biomarkers for liver steatosis in non-alcoholic fatty liver disease: present and future
Authors: Nogami Asako , Yoneda Masato , Iwaki Michihiro , Kobayashi Takashi , Honda Yasushi , Ogawa Yuji , Imajo Kento , Saito Satoru , Nakajima Atsushi
Published: December 2022

Non-alcoholic fatty liver disease is currently the most common chronic liver disease, affecting up to 25% of the global population. Simple fatty liver, in which fat is deposited in the liver without fibrosis, has been regarded as a benign disease in the past, but it is now known to be prognostic. In the future, more emphasis should be placed on the quantification of liver fat. Traditionally, fatty liver has been assessed by histological evaluation, which requires an invasive examination; however, technological innovations have made it possible to evaluate fatty liver by non-invasive imaging methods, such as ultrasonography, computed tomography, and magnetic resonance imaging. In addition, quantitative as well as qualitative measurements for the detection of fatty liver have become available. In this review, we summarize the currently used qualitative evaluations of fatty liver and discuss quantitative evaluations that are expected to further develop in the future.
Current Issues in Multiple Sclerosis: Selected Highlights of the ECTRIMS 2018 Congress
Authors: Judge Lindsay
Published: December 2022

The European Committee for the Treatment and Research in Multiple Sclerosis (ECTRIMS) has been convening an annual congress for more than 30 years with the aim of facilitating communication, creating synergies, and promoting and enhancing research and learning among professionals for the ultimate benefit of people affected by multiple sclerosis (MS).1 Since ECTRIMS has been active, the landscape in the management of MS has changed beyond recognition, from the emergence of disease-modifying treatments (DMT) in 1996 to the increasing availability of new treatment options for patients with relapsing MS and primary progressive MS, and potential treatment options on the horizon for secondary progressive MS.2 Most recently, the 34th ECTRIMS conference (ECTRIMS 2018) was held in Berlin, Germany, from 10th–12th October, and welcomed >9,400 researchers, neurologists, and MS professionals from 105 countries.3,4 Common themes explored included the value of real-world data in making treatment decisions, the use of biomarkers for neurodegeneration, and the ongoing challenges of treating progressive forms of MS.4 One key highlight was a ‘Free Communication’ presentation discussing the implications of the recent 2017 McDonald diagnostic criteria for MS.5,6 The consensus was that the new guidelines provide higher sensitivity and lower specificity for the diagnosis of MS, meaning that the proportion of patients diagnosed with MS has increased by nearly 25%, at the expense of the clinically isolated syndrome (CIS) diagnosis that would have been previously made. This has ethical, legal, and potential socio-economic implications for people previously diagnosed with CIS who may now fit the criteria for MS. It should also be noted that some experts believe that the revisions to the new guidelines may force treatment to be given too early, discounting the impact of neurodegeneration and adverse events associated with exposure to DMT, which must be considered. As it is not possible to review all areas covered during ECTRIMS 2018, three topics of particular interest have been selected for discussion in this article: 1) the management of MS in women of child-bearing age; 2) the measurement and management of disability progression; and 3) the management of long-term disease.
Rehabilitation of patients with peritoneal adhesive disease
Authors: Kostyuchenko L. N. , Smirnova O. A. , Lychkova A. E. , Vasina T. A. , Kostyuchenko M. V.
Published: December 2022

Adhesive disease is a syndrome caused by the presence of adhesions in the abdominal cavity, formed due to various reasons, and characterized by frequent bouts of relative intestinal obstruction.Purpose. Determine the complex of rehabilitation measures for adhesive disease.Material and methods. Patients with the following forms were observed: a) with pain syndrome (84.1%); b) with periodically recurring attacks of intestinal obstruction; c) there may also be asymptomatic SB (not found in observations). All patients had the following symptoms as pain, thirst, nausea (sometimes vomiting that does not bring relief), a feeling of heaviness in the abdomen, tachycardia, discomfort, flatulence, arterial hypertension. Ultrasound of the abdominal organs and laparoscopy, MSCT of the abdominal organs and plain radiography of the abdominal cavity and electrogastroenterography were performed to detect violations of the motor function of the gastrointestinal tract.Results and discussion. The complex of rehabilitation measures included the following rehabilitation. Outside the attack of adhesive disease (an attack of intestinal obstruction) and with adhesive dynamic obstruction, patients were treated conservatively; surgical rehabilitation was prescribed for an attack of adhesive mechanical obstruction. Conservative rehabilitation included exercise therapy, diet, folk remedies, medical correction.
Priorities in choosing prokinetic for patients with functional dyspepsia: Focus on itopride
Authors: Babich A. E. , Zubareva N. A. , Ketova G. G.
Published: December 2022

Functional dyspepsia is a widespread disease with many symptoms that reduce the patient's quality of life. The effectiveness of prokinetics, including in combination with proton pump inhibitors, has a high level of scientific evidence in the treatment of functional dyspepsia. The effectiveness of itopride hydrochloride is determined by a dual mechanism of action: antagonism to D 2-dopamine receptors and inhibition of acetylcholinesterase. The drug exceeds of metoclopramide and domperidone in safety in relation to cardiac and neurological disorders. Itopride hydrochloride is not expected to have pharmacokinetic interactions with other drugs metabolized by the CYP3A4 system. In addition to functional dyspepsia, itopride hydrochloride is indicated in the treatment of chronic gastritis, gastrointestinal symptoms associated with gastric dysmotility or delayed gastric emptying, such as bloating, rapid satiety, a feeling of fullness in the stomach after eating, pain or discomfort in the epigastric region, loss of appetite, heartburn, nausea and vomiting. The pharmacoeconomic analysis shows an advantage of Itopride-SZ in comparing of the direct cost of it with the original and several generic drugs. In this way, it allows recommend Itopride-SZ as an affordable drug for various cohorts of patients.
Percutaneous endoscopic gastrostomy in patients with neurodegenerative diseases
Authors: Lapteva E. S. , Kulibaba D. M. , Tsai A. F. , Saveliev V. G. , Shubinsky V. D.
Published: December 2022

Introduction. In recent years, there has been a clear trend in the use of high-tech treatment methods known in medicine in the provision of palliative care to improve the quality of life of patients with amyotrophic lateral sclerosis and spinal muscular atrophy.Target. To evaluate the effectiveness of minimally invasive treatment technologies used in the City Geriatric Medical and Social Centre (St. Petersburg, Russia) to restore full enteral nutrition in incurable patients in the provision of palliative care.Materials and methods. An observational retrospective cohort study based on archival case histories of patients with amyotrophic lateral sclerosis and spinal muscular atrophy admitted to the Respiratory Support Centre at the City Geriatric Medical and Social Centre (St. Petersburg, Russia) was conducted in 2018–2021.Results and discussion. The most commonly used method of restoring natural enteral nutrition in patients with amyotrophic lateral sclerosis and spinal muscular atrophy was percutaneous endoscopic gastrostomy performed according to the PULL (pullthrough) method according to Gauderer–Ponsky (pulling on itself), and in patients with severe malnutrition, percutaneous endoscopic gastrostomy according to PUSH technique using introducers. Also in demand was the endoscopic replacement of the gastrostomy tube with a gastrostomy bolus tube. Performing percutaneous endoscopic gastrostomy in difficult clinical conditions (patient position, oropharyngeal paresis, stiffness and contractures in the cervical and upper thoracic spine, impaired mental status) required highly qualified personnel capable of providing full-fledged surgical, anesthesiology and endoscopic care. The nature of postoperative complications made it possible in all cases to achieve their elimination in the early postoperative periods without lethal outcomes.Conclusions. The evolution of methods and methods of providing palliative care corresponds to the general trend in the development of medicine and strives for high-tech, highly informative methods of treatment. With the use of modern methods of specialized treatment, the number of failures in clinical practice is reduced and the professional competence of specialists in the palliative care department is increased. Percutaneous endoscopic gastrostomy in patients with amyotrophic lateral sclerosis and spinal muscular atrophy, diagnosis of possible early or late complications require the participation of a qualified surgeon, endoscopist and anesthesiologist, as well as the use of the entire range of diagnostic methods possible in a multidisciplinary hospital. The transition to high-tech methods of providing palliative care using modern instrumental techniques requires both legislative and timely budgetary support.
Assessment of nutritional status of secondary vocational education students (on example of medical college)
Authors: Latyshevskaya N. I. , Davydenko L. A. , Belyaeva A. V. , Zub A. V. , Levchenko N. V.
Published: December 2022

Relevance. Currently, one of the most common risk factors for young students is eating disorders, manifested by high rates of overweight and obesity among adolescents.The purpose of the study. To study the nature of nutrition and the features of the component composition of the body of medical college students.Materials and methods. The observation group consisted of students of the 1st and 3rd courses of the medical college. Measured: height, body weight, fat-free body weight (BZHMT), fat mass (fat) and its proportion (% fat), active cell mass (ACM) and its proportion (%), the amount and distribution of fluid in the body, metabolic parameters.Results and discussion. Violations of the regularity of food intake, the absence of a number of biologically valuable foods in the daily diet of most students, more often in senior students, more often in girls, were revealed. Students' meals are associated with frequent visits to public catering places. During the period of study, the number of overweight and obese students increases. The results showed an increase in LM, a more pronounced increase in the per cent of LM of the body in young men, a decrease in the proportion of BZHM and AKM in the component composition of the body. The results of the correlation analysis confirmed that the increase in MT and BMI is more due to an increase in adipose tissue in young men. It was found that the BMI in boys is mainly due to the fat component, in girls to the fat and muscle components. They argue the need to develop preventive measures to rationalize the nutrition of students, including on the basis of an educational organization of secondary vocational education and correction of students' motor activity.
In silico host-pathogen surface interaction of entomopathogeic fungi, Beauveria bassiana
Authors: Mondal Subhoshmita , Singh Pankaj Kumar
Published: December 2022

The classical usage of myco-biocontrol agents for agricultural pests globally has involved the group entomopathogenic fungi with enhanced habitat manipulation. The classified entomopathogenic fungi, Beauveria bassiana is one of the significant host with effective control on population of insect-pests. It is considered, the cuticle signifies the key point of fence contact between the fungus and the insect. Knowledge of molecular mechanisms analysed using computational methods, may define interactions that eventually can direct either to successful mycosis by the pathogen or defense by the hosts. Apart conventional experimental method, we have approached with an in-silico pipeline to define the facts of surface contact of Beauveria bassiana with its two promising hosts, Nilaparvata lugens and Sodoptera exigua. The protein sequences were retrieved and subjected to modeller followed by validated structural integrity and simulation. Later, all simulated protein structures were docked to extensively study the contact of host-pathogen that includes surface protein-protein interactions.
SISTEM INFORMASI PREDIKSI KEBUTUHAN BAHAN MENTAH MENGGUNAKAN METODE SINGLE EXPONENTIAL SMOOTHING
Authors: Muhammad Unggul Pamenang  , Yoppy Yunhasnawa  , Devi Wahyu Devi Nur Hamidah
Published: December 2022

Rumah Makan Waroeng Sumber Gentong merupakan satu dari sekian banyak bisnis kuliner di kabupaten Malang yang cukup banyak digemari masyarakat. Namun Waroeng Sumber Gentong juga memiliki persoalan yang terjadi ialah rumah makan ini tidak dapat memperkirakan persediaan bahan mentah dimasa mendatang. Oleh karena itu Rumah Makan Waroeng Sumber Gentong perlu dilakukan suatu peramalan pada usaha bisnis kulinernya agar terhindar dari kurigian dimasa yang akan datang. Mengenai permasalahan yang terjadi diatas, metode yang cocok dalam studi kasus ini adalah Metode Single Exsponential Smoothing sebab metode ini tergolong dalam time series (runtut waktu) yang mempergunakan data masa lalu untuk mempredisi suatu dimasa akan datang. Data yang digunakan pada penelitian ini ialah histori data bahan mentah 1.5 tahun , mulai Januari 2021 sampai Mei 2022. Berikutnya data diolah dengan metode Single Exsponential Smoothing. Dengan menggunakan nilai alpha 0<α<1, untuk melakukan perbandingan dengan nilai alpha sampai ditemukan alpha dengan nilai error paling sedikit. Hasil pengujian untuk data bahan baku cabe rawit merah pada periode Januari 2022- Mei 2022 ditemukan nilai eror terkecil sebesar 7.31% menggunakan MAPE (Mean Absolute Percentage Error).
Ser criança em instituição de acolhimento
Authors: Silva Lucia Cecilia da , Oliveira Alexsandra
Published: December 2022

O artigo tem por objetivo apresentar o resultado de uma pesquisa que buscou compreender a vivência de crianças em processo de acolhimento institucional sob a ótica fenomenológica. Participaram da pesquisa quatro crianças de sete a dez anos, acolhidas em três instituições da região noroeste do Estado do Paraná. A coleta de dados se deu por meio da observação e do contato com as crianças em suas atividades rotineiras, e, sobretudo, da escuta de suas falas nas atividades e interações com as pessoas de sua convivência nas instituições. Também se utilizou de informações contidas em seus prontuários para esclarecimentos sobre suas histórias de vida. A análise dos dados revelou três unidades de significado: 1) Motivos do acolhimento; 2) A família, e 3) O lar e a casa lar. Verificou-se que as crianças vivenciam a casa lar como punitiva, distanciando-se de seu papel protetivo e reduzindo o espaço a uma simples fonte supridora de necessidades básicas. Por outro lado, as relações ali instituídas são consideradas positivas, embora não sejam percebidas com o caráter familiar de um lar como almeja o Estatuto da Criança e do Adolescente.
Enquadramentos noticiosos no Jornal da Record e no Jornal Nacional: um estudo comparativo
Authors: Silva Daniel Batista de Jesus da , Negrini Michele
Published: December 2022

O Jornal da Record e o Jornal Nacional são destaques no espaço telejornalístico brasileiro. A política faz parte da pauta dos dois telejornais. E, no caso da demissão de Sérgio Moro do Ministério da Justiça e Segurança Pública, o Jornal da Record e o Jornal Nacional fizeram ampla cobertura ao fato. Assim, o foco deste artigo é analisar os enquadramentos construídos sobre o pedido de demissão do ex-ministro, nas edições de 24 e 25 de abril de 2020 dos dois telejornais, estabelecendo um comparativo. Os procedimentos analíticos são norteados pelo método observacional (GIL, 2008). Ambos destacam o potencial conflitivo, mas diferem na ênfase promovida sobre a causa da demissão, o que tornou-se mais evidente utilizando o conceito de enquadramento.
Chirality and frequency measurement of longitudinal rolling of human sperm using optical trap
Authors: Zhong Zhensheng , Zhang Can , Liu Rui , He Jun , Yang Han , Cheng Zijie , Wang Tao , Shao Meng , Fang Shu , Zhang Shengzhao , Shi Hui , Xue Rufeng , Zou Huijuan , Ke Zeyu , Zhang Zhiguo , Zhou Jinhua
Published: December 2022

Motility is one of the most critical features to evaluate sperm quality. As longitudinal rolling of human sperm has long been ignored until recently, its detailed dynamics and cellular biological mechanisms are still largely unknown. Here we report an optical-tweezers-based method to evaluate the chirality and frequency of sperm rotation. According to the intensity distribution patterns of off-focus micron-size particles, we established a method to judge the orientation of the sperm head along the optical axis in the optical trap. Together with the rotation direction of the projection of the sperm head, the chirality of longitudinal rolling of sperm can be measured without the application of three-dimensional tracking techniques or complex optical design. By video tracking optically trapped sperm cells from different patients, both rolling chirality and rolling frequency were analyzed. In this study, all the vertically trapped human sperm cells adopt a right-hand longitudinal rolling. The orientation and rolling frequency but not the rolling chirality of sperm in the optical trap are affected by the trap height. The rotation analysis method developed in this study may have clinical potential for sperm quality evaluation.
Advances and perspectives for antimicrobial peptide and combinatory therapies
Authors: C Santos , G. R Rodrigues , L. F Lima , M.C.G dos Reis , N.B Cunha , S.C Dias , O. L Franco
Published: December 2022

Antimicrobial peptides (AMPs) have shown cell membrane-directed mechanisms of action. This specificity can be effective against infectious agents that have acquired resistance to conventional drugs. The AMPs’ membrane-specificity and their great potential to combat resistant microbes has brought hope to the medical/therapeutic scene. The high death rate worldwide due to antimicrobial resistance (AMR) has pushed forward the search for new molecules and product developments, mainly antibiotics. In the current scenario, other strategies including the association of two or more drugs have contributed to the treatment of difficult-to-treat infectious diseases, above all, those caused by bacteria. In this context, the synergistic action of AMPs associated with current antibiotic therapy can bring important results for the production of new and effective drugs to overcome AMR. This review presents the advances obtained in the last 5 years in medical/antibiotic therapy, with the use of products based on AMPs, as well as perspectives on the potentialized effects of current drugs combined with AMPs for the treatment of bacterial infectious diseases.
The UBE2D ubiquitin conjugating enzymes: Potential regulatory hubs in development, disease and evolution
Authors: Roman-Trufero Monica , Dillon Niall
Published: December 2022

Ubiquitination of cellular proteins plays critical roles in key signalling pathways and in the regulation of protein turnover in eukaryotic cells. E2 ubiquitin conjugating enzymes function as essential intermediates in ubiquitination reactions by acting as ubiquitin donors for the E3 ubiquitin ligase enzymes that confer substrate specificity. The members of the UBE2D family of E2 enzymes are involved in regulating signalling cascades through ubiquitination of target proteins that include receptor tyrosine kinases (RTKs) and components of the Hedgehog, TGFβ and NFκB pathways. UBE2D enzymes also function in transcriptional control by acting as donors for ubiquitination of histone tails by the Polycomb protein Ring1B and the DNA methylation regulator UHRF1 as well as having roles in DNA repair and regulation of the level of the tumour suppressor p53. Here we review the functional roles and mechanisms of regulation of the UBE2D proteins including recent evidence that regulation of the level of UBE2D3 is critical for controlling ubiquitination of specific targets during development. Cellular levels of UBE2D3 have been shown to be regulated by phosphorylation, which affects folding of the protein, reducing its stability. Specific variations in the otherwise highly conserved UBE2D3 protein sequence in amniotes and in a subgroup of teleost fishes, the Acanthomorpha, suggest that the enzyme has had important roles during vertebrate evolution.
GARP dysfunction results in COPI displacement, depletion of Golgi v-SNAREs and calcium homeostasis proteins
Authors: Khakurel Amrita , Kudlyk Tetyana , Pokrovskaya Irina , D’Souza Zinia , Lupashin Vladimir V.
Published: December 2022

Golgi-associated retrograde protein (GARP) is an evolutionary conserved heterotetrameric protein complex that tethers endosome-derived vesicles and is vital for Golgi glycosylation. Microscopy and proteomic approaches were employed to investigate defects in Golgi physiology in RPE1 cells depleted for the GARP complex. Both cis and trans-Golgi compartments were significantly enlarged in GARP-knock-out (KO) cells. Proteomic analysis of Golgi-enriched membranes revealed significant depletion of a subset of Golgi residents, including Ca2+ binding proteins, enzymes, and SNAREs. Validation of proteomics studies revealed that SDF4 and ATP2C1, related to Golgi calcium homeostasis, as well as intra-Golgi v-SNAREs GOSR1 and BET1L, were significantly depleted in GARP-KO cells. Finding that GARP-KO is more deleterious to Golgi physiology than deletion of GARP-sensitive v-SNAREs, prompted a detailed investigation of COPI trafficking machinery. We discovered that in GARP-KO cells COPI is significantly displaced from the Golgi and partially relocalized to the ER-Golgi intermediate compartment (ERGIC). Moreover, COPI accessory proteins GOLPH3, ARFGAP1, GBF1, and BIG1 are also relocated to off-Golgi compartments. We propose that the dysregulation of COPI machinery, along with the depletion of Golgi v-SNAREs and alteration of Golgi Ca2+ homeostasis, are the major driving factors for the depletion of Golgi resident proteins, structural alterations, and glycosylation defects in GARP deficient cells.