bluuebunny/crossref_metadata_2025 huggingface dataset:
Empire and the Meaning of Religion in Northeast Asia
Authors: DuBois Thomas David
Published: January 2017

Manchuria entered the twentieth century as a neglected backwater of the dying Qing dynasty, and within a few short years became the focus of intense international rivalry to control its resources and shape its people. This book examines the place of religion in the development of Manchuria from the late nineteenth century to the collapse of the Japanese Empire in 1945. Religion was at the forefront in this period of intense competition, not just between armies but also among different models of legal, commercial, social and spiritual development, each of which imagining a very specific role for religion in the new society. Debates over religion in Manchuria extended far beyond the region, and shaped the personality of religion that we see today. This book is an ambitious contribution to the field of Asian history and to the understanding of the global meaning and practice of the role of religion.
The Peacebuilding Puzzle
Authors: Barma Naazneen H.
Published: January 2017

Transformative peace operations fall short of achieving the modern political order sought in post-conflict countries because the interventions themselves empower post-conflict elites intent on forging a neopatrimonial political order. The Peacebuilding Puzzle explains the disconnect between the formal institutional engineering undertaken by international interventions, and the governance outcomes that emerge in their aftermath. Barma's comparative analysis of interventions in Cambodia, East Timor, and Afghanistan focuses on the incentives motivating domestic elites over a sequence of three peacebuilding phases: the elite peace settlement, the transitional governance period, and the aftermath of intervention. The international community advances certain forms of institutional design at each phase in the pursuit of effective and legitimate governance. Yet, over the course of the peacebuilding pathway, powerful post-conflict elites co-opt the very processes and institutions intended to guarantee modern political order and dominate the practice of governance within those institutions to their own ends. This title is also available as Open Access.
A NEYMAN-PEARSON PERSPECTIVE ON OPTIMAL REINSURANCE WITH CONSTRAINTS
Authors: Lo Ambrose
Published: January 2017

The formulation of optimal reinsurance policies that take various practical constraints into account is a problem commonly encountered by practitioners. In the context of a distortion-risk-measure-based optimal reinsurance model without moral hazard, this article introduces and employs a variation of the Neyman–Pearson Lemma in statistical hypothesis testing theory to solve a wide class of constrained optimal reinsurance problems analytically and expeditiously. Such a Neyman–Pearson approach identifies the unit-valued derivative of each ceded loss function as the test function of an appropriate hypothesis test and transforms the problem of designing optimal reinsurance contracts to one that resembles the search of optimal test functions achieved by the classical Neyman–Pearson Lemma. As an illustration of the versatility and superiority of the proposed Neyman–Pearson formulation, we provide complete and transparent solutions of several specific constrained optimal reinsurance problems, many of which were only partially solved in the literature by substantially more difficult means and under extraneous technical assumptions. Examples of such problems include the construction of the optimal reinsurance treaties in the presence of premium budget constraints, counterparty risk constraints and the optimal insurer–reinsurer symbiotic reinsurance treaty considered recently in Cai et al. (2016).
Venture Capital Exits and the Structure of Stock Markets in China
Authors: LIN Lin
Published: January 2017

Existing literature suggests a strong relationship between a vibrant venture capital market and an active stock market: venture capital flourishes when venture capitalists can readily exit from successful portfolio companies through IPOs, and IPOs are in turn facilitated by active and efficient stock markets. This article uses China as a case study to explore the connection between the stock market and venture capital market. Through empirical studies, this article confirms the existing literature by demonstrating a close connection between the stock market and venture capital market in China. It also refines the existing literature by finding that, for venture capital availability, laws and policies also matter in China. Strong and sustained law reforms and government policies aimed at improving the institutional structure and regulatory environment of the stock market can facilitate venture capital-backed exits, which in turn lead to an increase in new venture capital availability in China. Nonetheless, numerous IPO closures have led to freeze-ups in China’s venture capital market. Also, there remain a multiplicity of institutional impediments to the efficient operation of the stock market and the effective implementation of IPO reforms in China. These may in turn hinder the development of the Chinese venture capital industry.
Migration: A means to create work–life balance?
Authors: Dyer Suzette , Xu Yiran , Sinha Paresha
Published: January 2017

In this article, we examine the postmigration work–life balance or conflict experiences of 15 Chinese-born mothers living in New Zealand. Our analysis contributes theoretically to the work–life balance and migration literatures. It does so by revealing that balance and conflict is influenced by the interrelationship between the socio-cultural, work, and family domains; and that this interrelationship has both a complex and nuanced influence on postmigration balance and conflict. Thus, balance or conflict was influenced by the interrelationship between the participants’ unique experiences within the three domains, including experiencing satisfaction in all three domains and through complex processes of negative spillover, compensation, renegotiation and removal. The postmigration experiences highlight the need for a comprehensive and concerted approach by government, tertiary education institutions, and human resource managers to develop responsive policy initiatives that support migrants to settle into all aspects of their lives.
Farhat J. Ziadeh 1917–2016
Authors: Heer Nicholas
Published: January 2017

Farhat Jacob Ziadeh, founder and first chairman of the Department of Near Eastern Languages and Civilization at the University of Washington, and a distinguished scholar in the field of Islamic law, writer, teacher, and administrator, died on 8 June 2016 at the age of ninety-nine. Ziadeh was born on 8 April 1917 in Ramallah, Palestine where he received his early education. After graduating from the American University of Beirut in 1937, he studied law at the University of London, receiving an LL.B. degree in 1940. For the next eight years he worked as a lawyer and Arabic instructor in the United States, England, and Palestine. In 1948, he joined the Princeton University faculty as a lecturer in Arabic. The following year he married Suad Salem, who, like himself, was also from Ramallah. They raised five daughters: Shireen, Susan, Rhonda, Deena, and Reema. In 1950, Ziadeh began working with the Voice of America in New York as the editor of the Arabic desk. Since this was a full-time job, he could continue as a lecturer at Princeton only on a part-time basis. In 1954, however, Princeton offered him an assistant professorship, which he accepted. At Princeton, Ziadeh collaborated with the late R. Bayly Winder to write An Introduction to Modern Arabic (1957). It was during this period also that Ziadeh began to work on his translation of Ṣubḥī Maḥmaṣānī’s Falsafat al-Tashrīʿ fī al-Islām under the title, Mahmassani's Philosophy of Jurisprudence in Islam (1961).
Dairy consumption is associated with a lower incidence of the metabolic syndrome in middle-aged and older Korean adults: the Korean Genome and Epidemiology Study (KoGES)
Authors: Kim Dasom , Kim Jihye
Published: January 2017

This cohort study examined the association between total and individual dairy products and the risk of developing the metabolic syndrome (MetS) and its components in Korean adults from the Korean Genome and Epidemiology Study. We prospectively analysed 5510 participants aged 40–69 years without the MetS at baseline during a 10-year follow-up period. Dairy consumption was assessed with a semi-quantitative FFQ at baseline and after 4 years. The MetS was defined according to the criteria by the National Cholesterol Education Program Adult Treatment Panel III. The Cox’s proportional hazard model was used to examine the association between consumption of total dairy products, milk and yogurt in servings per week and the risk of incident MetS or individual components. A total of 2103 subjects developed the MetS (38·2 %) during an average follow-up of 67·4 months (range 17–104 months). Frequent dairy consumption (>7 servings of total dairy and milk/week, ≥4 servings of yogurt/week) was associated with a reduced risk of incident MetS and its components. In the multivariable adjusted model, hazard ratios for the MetS were 0·51 (95 % CI 0·43, 0·61) for total dairy products, 0·50 (95 % CI 0·38, 0·66) for milk and 0·67 (95 % CI 0·57, 0·78) for yogurt in frequent consumers compared with non-consumers. An inverse association between milk/yogurt and low HDL-cholesterol was shown only in women. In conclusion, high consumption of individual dairy products including milk and yogurt as well as total dairy were associated with a reduced risk of incident MetS and individual components in Korean adults.
Whither the Funnel of Causality?
Authors: Wilder Matt
Published: January 2017

If Richard Simeon's “Studying Public Policy” sought to inspire a theory of policy making, however tentative or crude, its conceptual cornerstone was no doubt the “funnel of causality.” Yet references to the funnel of causality have all but disappeared from the policy literature. This article traces the evolution of the thinking that underlies the funnel of causality with the aim of demonstrating its lasting relevance to policy studies. Being a method for understanding how inputs from various levels of abstraction impact policy outcomes, the interaction and feedback effects implicit in the funnel metaphor have been maintained in subsequent neo-institutionalist work that takes seriously the institutional and sociological environment in which policy making takes place, particularly that which is interested in the origins and operation of policy subsystems, policy communities or networks, and policy regimes.
“Bad” Politics and “Good” Culture: New Approaches to the History of the Weimar Republic
Authors: Hung Jochen
Published: January 2017

More than thirty years ago, Eberhard Kolb commented that the vast wealth of research on the history of the Weimar Republic made it “difficult even for a specialist to give a full account of the relevant literature.” Since then, the flood of studies on Weimar Germany has not waned, and by now it is hard even to keep track of all the review articles meant to cut a swath through this abundance. Yet the prevailing historical image of the era has remained surprisingly stable: most historians have accepted the master narrative of the Weimar Republic as the sharp juxtaposition of “bad” politics and “good” culture, epitomized in the often-used image of “a dance on the edge of a volcano.” Kolb, for example, described “the sharp contrast between the gloomy political and economic conditions … and the unique wealth of artistic and intellectual achievement” as “typical of the Weimar era.” Detlev Peukert, arguably the most innovative scholar of Weimar history, criticized this historical image but, at the same time, declared this dichotomy “an integral feature of the era.” The latest example can be found in the work of Eric D. Weitz, who summarizes the fate of Weimar Germany as “the striving for something new and wonderful encountering absolute evil,” juxtaposing the “sparkling brilliance” of modernist masters like Bertolt Brecht, Thomas Mann, and Bruno Taut with “the plain hatred of democracy” of Weimar's right-wing extremists. This contrasting of politics and culture is a narrative device that only makes sense, however, from our contemporary vantage point of Western liberal democracy and from our understanding of progressive art. This retrospective interpretation is not in itself the problem—after all, historians can never really escape their own historical contexts. It becomes problematic, however, when it is treated not as an interpretation but as historical fact. Weimar Germans certainly would not have shared this narrative wholeheartedly: many would not have subscribed to the depiction of their time as a never-ending parade of political breakdowns and economic disasters. Even more would have rejected the view of the Berlin-based avant-garde as a sign of progressive achievement—if they had ever had the chance to see its representative works in the first place. The sharp distinction between “bad” Weimar politics and “good” Weimar culture not only fails to do justice to the way many of these Germans perceived their time but also keeps us from understanding how closely intertwined these two spheres were in the Weimar Republic. Thus, rather than giving an overview of the latest additions to Weimar historiography, this review essay looks at how recent publications have questioned—or conformed to—this dominant narrative.
The Lawyer Who Mocked Hitler, and Other Jewish Commentaries on the Nuremberg Laws
Authors: Morris Douglas G.
Published: January 2017

Nazi Germany’s Nuremberg Laws of 1935 generated legal commentary by Nazi jurists who eagerly extended its antisemitic principles—but not by Jewish lawyers, for whom the discrimination was too blatant and the risks of public criticism too dangerous. In the winter of 1936-37 in Leipzig, however, one obscure lawyer named Max Hellmann made an incisive commentary about the laws. Faced with prosecution for employing a female “Aryan” cook, Hellmann, a convert and widower in despair, responded boldly: he subpoenaed Adolf Hitler to testify and even moved to imprison him pending the judge’s decision. His defense was, in fact, a satire. It mocked the so-called Führerprinzip (leadership principle), i.e., the idea of law as the Führer’s will, at the heart of the Nazi legal system. Persistently contrasting the need for legal procedures with the primacy of irrational will, Hellmann showed that the leadership principle was incoherent with regard to the separation of powers, the role of the judiciary, the process of legislation, and the very nature of law itself. He provided a detailed critique of Nazi law that insiders, such as Nazi jurists, dared not think, and that outsiders, such as Jewish lawyers, had no reason to develop.
La métaphysique et l’intérêt pratique chez Kant. Remarques sur la transition vers la systématicité idéaliste
Authors: DUMONT AUGUSTIN
Published: January 2017

L’objectif de cet article est d’interroger la transition Kant-Fichte sur le double plan de la systématicité et du primat de la raison pratique. S’il est admis que Kant voyait dans l’exercice critique l’occasion de renouveler, plutôt que de supprimer, la possibilité d’une métaphysique positive, il est aujourd’hui convenu de rapporter son ébauche de «système» au seul héritage de laSchulmetaphysik. A contrario, on cherche ici à prendre à la lettre l’exigence kantienne d’un système qui attend du «pratique» une nouvelle et absolue «fondation», plutôt qu’il ne devrait être complété en l’état. La perspective fichtéenne impose alors son fil rouge.
Effect of the patient-to-patient communication model on dysphagia caused by total laryngectomy
Authors: Tian L , An R , Zhang J , Sun Y , Zhao R , Liu M
Published: January 2017

Objective:

The study aimed to evaluate the effect of a patient-to-patient communication model on dysphagia in laryngeal cancer patients after total laryngectomy.

Methods:

Sixty-five patients who had undergone total laryngectomy were randomly divided into three groups: a routine communication group, a patient communication group (that received the patient-to-patient communication model) and a physician communication group. Questionnaires were used to compare quality of life and swallowing problems among all patient groups.

Results:

The main factors causing dysphagia in total laryngectomy patients were related to fear and mental health. The patient communication group had improved visual analogue scale scores at one week after starting to eat. Quality of life in swallowing disorders questionnaire scores were significantly higher in the patient communication and physician communication groups than in the routine communication group. In addition, swallowing problems were much more severe in patients educated to high school level and above than in others.

Conclusion:

The patient-to-patient communication model can be used to resolve swallowing problems caused by psychological factors in total laryngectomy patients.
One hundred years of external approach medialisation thyroplasty
Authors: Crolley V E , Gibbins N
Published: January 2017

It has been 100 years since Erwin Payr first developed an operation to improve the effects of a paralysed vocal fold, and operations based on this technique are still in use today. This technique, medialisation thyroplasty, aims to improve the symptoms caused by vocal fold palsy by realigning the lateralised vocal fold into the midline.

Whilst the effects of vocal fold palsy were recognised in antiquity, it was only with the development of indirect laryngoscopy in the late nineteenth century that the vocal fold paralysis could be identified as an aetiology for poor phonation and dysphagia. Payr, in 1915, was the first to perform a recognisable form of medialisation thyroplasty, which was further developed in the early twentieth century, but medialisation thyroplasty did not begin to be widely used until the development of the modern technique by Isshikiet al., in 1974.

Since then, medialisation thyroplasty has continued to be developed and is currently the most widely used technique for correcting the effects of vocal fold palsy. However, a wide array of therapeutic options is now available for vocal fold palsy and it is impossible to say whether or not medialisation thyroplasty will still be used in another 100 years.
Safe balloon sizing for endoscopic dilatation of subglottic stenosis in children
Authors: Sharma S D , Gupta S L , Wyatt M , Albert D , Hartley B
Published: January 2017

Objectives:

To describe our experience and provide guidelines for maximum safe balloon sizes according to age in children undergoing balloon dilatation.

Method:

A retrospective review was conducted of children undergoing balloon dilatation for subglottic stenosis in a paediatric tertiary unit between May 2006 and February 2016.

Results:

A total of 166 patients underwent balloon dilatation. Mean ( ± standard deviation) patient age was 4.5 ± 3.99 years. The median balloon size was 8 mm, the median balloon inflation pressure was 10 atm, and the mean balloon inflation time was 65.1 ± 18.6 seconds. No significant unexpected events occurred. The Pearson correlation co-efficient for the relationship between patient age and balloon size was 0.85 (p = 0.001), suggesting a strongly positive correlation.

Conclusion:

This study demonstrated that balloon dilatation is a safe procedure for airway stenosis. The results suggest using a balloon diameter that is equal to the outer diameter of the age-appropriate endotracheal tube +1 mm for the larynx and subglottis and +2 mm for the trachea.
Capronia suijae(Herpotrichiellaceae, Eurotiomycetes), a new fungus onXanthoria parietinafrom Belarus, with a key to the lichenicolous species growing onXanthorias. str.
Authors: TSURYKAU Andrei , ETAYO Javier
Published: January 2017

The new lichenicolous fungusCapronia suijaegrowing on the thallus of corticolousXanthoria parietinais described from Belarus and compared with similar species. In addition to its host selection, the species is characterized by comparatively small ascomata, 40–80 μm diam., and (0–1–)3-septate ascospores, 9·5–11·5×4·0–5·0 μm. A key to the lichenicolous fungi growing onXanthorias. str. is provided.
Platythecium seychellense, a new species in the family Graphidaceae (lichenized Ascomycota: Ostropales) from the Seychelles and a world key to the genus
Authors: NEUWIRTH Gerhard , APTROOT André , STOCKER-WÖRGÖTTER Elfie
Published: January 2017

The new corticolous lichen fungus Platythecium seychellense is described from the Seychelles. Morphological characters as well as distribution and resemblance to related species are discussed. The species is characterized by a crustose, grey-green, smooth thallus lacking lichen substances, elongate and slender apothecia having flat, red-brown discs and grey 3-septate ascospores. A world key to all currently known species in the genus is presented.
Insights into the genus Austrella (Pannariaceae, Peltigerales), including a new species from the Falkland Islands
Authors: FRYDAY Alan M. , ERTZ Damien , JØRGENSEN Per Magnus
Published: January 2017

The new species Austrella isidioidea, which is unique in the genus in having isidioid structures on the thallus lobe ends as well as apothecia lacking a thalline margin, is described from the Falkland Islands. A collection with an identical mtSSU rDNA sequence to A. arachnoidea but with significant morphological differences (viz. a variable apothecial margin ranging from an arachnoid hyphal weft to a corticated regular margin) is reported from Îles Kerguelen. The phylogenetic and biogeographical implications of these new records are discussed.
Epidemiology of parainfluenza infection in England and Wales, 1998–2013: any evidence of change?
Authors: ZHAO H. , HARRIS R. J. , ELLIS J. , DONATI M. , PEBODY R. G.
Published: January 2017

Human parainfluenza virus (HPIV) infections are one of the commonest causes of upper and lower respiratory tract infections. In order to determine if there have been any recent changes in HPIV epidemiology in England and Wales, laboratory surveillance data between 1998 and 2013 were analysed. The UK national laboratory surveillance database, LabBase, and the newly established laboratory-based virological surveillance system, the Respiratory DataMart System (RDMS), were used. Descriptive analysis was performed to examine the distribution of cases by year, age, sex and serotype, and to examine the overall temporal trend using the χ2 test. A random-effects model was also employed to model the number of cases. Sixty-eight per cent of all HPIV detections were due to HPIV type 3 (HPIV-3). HPIV-3 infections were detected all year round but peaked annually between March and June. HPIV-1 and HPIV-2 circulated at lower levels accounting for 20% and 8%, respectively, peaking during the last quarter of the year with a biennial cycle. HPIV-4 was detected in smaller numbers, accounting for only 4% and also mainly observed in the last quarter of the year. However, in recent years, HPIV-4 detection has been reported much more commonly with an increase from 0% in 1998 to 3·7% in 2013. Although an overall higher proportion of HPIV infection was reported in infants (43·0%), a long-term decreasing trend in proportion in infants was observed. An increase was also observed in older age groups. Continuous surveillance will be important in tracking any future changes.
Chronic Fatigue Syndrome: Cognitive, Behavioural and Emotional Processing Vulnerability Factors
Authors: Brooks Samantha K. , Chalder Trudie , Rimes Katharine A.
Published: January 2017

Background: Cognitive-behavioural models of chronic fatigue syndrome (CFS) suggest that personality factors such as perfectionism and high moral standards may contribute to the development of CFS. Aims: To investigate cognitive, behavioural and emotional processing risk factors for CFS. Method: CFS patients (n = 67) at a UK specialist clinic completed questionnaires about psychological characteristics both currently and retrospectively (6 months pre-CFS onset). Responses were compared with those of healthy individuals (n = 73) who rated their current characteristics. Forty-four relatives retrospectively rated the pre-morbid psychological characteristics of the CFS participants. Results: CFS patients showed similar levels of current perfectionism to controls, though higher pre-morbid perfectionism. CFS patients showed greater self-sacrificial beliefs and more unhelpful beliefs about experiencing and expressing negative emotions, both currently but more markedly prior to onset. In the 6 months pre-illness onset, CFS patients showed more disruption to their primary goal and greater general stress than controls. Ratings of pre-morbid psychological characteristics by relatives were consistent with patients’ self-reports. The extent of overinvestment in one goal was significantly associated with fatigue. Conclusions: Perfectionism, self-sacrificial tendencies, unhelpful beliefs about emotions, and perceived stress may be present to a greater extent pre-morbidly in CFS patients compared with healthy individuals.
Proper names used as modifiers: a comprehensive functional analysis
Authors: BREBAN TINE
Published: January 2017

My central concern is the special use of proper names in the English noun phrase first discussed by Rosenbach (2006, 2007, 2010; Koptjevskaja-Tamm & Rosenbach 2005): proper names which are used as modifiers with an identifying function, e.g.theBushadministration(‘Which administration does the noun phrase refer to? The one headed by Bush’). On the basis of a corpus study, I argue that existing analyses of Rosenbach (2007) and Schlücker (2013) fail to account for all cases; they also fail to capture the seemingly contradictory syntactic and functional properties of these proper names in a unified way. My alternative analysis is framed within Halliday's (1994) functional model of the English noun phrase, but radically thinks beyond the typical association of functions with word classes (see also Rijkhoff 2009). My proposal is that the majority of these proper names can be analysed as epithets, a function typically associated with adjectival modifiers such astheredcar. A smaller set, proper name modifiers such asaKerrysupporter, are analysed as complements (Payne & Huddleston 2002). I end by discussing the implications of this dual analysis for another open question, whether proper name modifiers are morphosyntactically phrasal modifiers or part of compounds.
How expensive is a cardioprotective diet? Analysis from the CRESSIDA study
Authors: Reidlinger Dianne P , Sanders Thomas AB , Goff Louise M
Published: January 2017

Objective

To determine whether a cardioprotective dietary intervention based on UK dietary guidelines was more expensive than a conventional UK diet.

Design

Cost analysis of food records collected at baseline and after a 12-week dietary intervention of a cardioprotective diet v. conventional UK diet.

Setting

A randomized controlled dietary intervention study (CRESSIDA; ISRCTN 92382106) investigating the impact of following a diet consistent with UK dietary guidelines on CVD risk.

Subjects

Participants were healthy UK residents aged 40–70 years. A sub-sample of participants was randomly selected from those who completed the cardioprotective dietary intervention (n 20) or the conventional UK dietary intervention (n 20).

Results

Baseline diet costs did not differ between groups; mean daily food cost for all participants was £6·12 (sd £1·83). The intervention diets were not more expensive: at end point the mean daily cost of the cardioprotective diet was £6·43 (sd £2·05) v. the control diet which was £6·53 (sd £1·53; P=0·86).

Conclusions

There was no evidence that consumption of a cardioprotective diet was more expensive than a conventional dietary pattern. Despite the perception that healthier foods are less affordable, these results suggest that cost may not be a barrier when modifying habitual intake and under tightly controlled trial conditions. The identification of specific food groups that may be a cost concern for individuals may be useful for tailoring interventions for CVD prevention for individuals and populations.
Implementing and integrating a radiation oncology information system as a pedagogical tool for undergraduate radiation therapy training
Authors: Chamunyonga Crispen , Rutledge Peta , Caldwell Peter , Burbery Julie
Published: January 2017

Purpose

Radiation oncology information systems (OIS) play a crucial role in radiation therapy by ensuring accurate and safe delivery of treatment. A MOSAIQ OIS system is currently used to support undergraduate radiation therapist training at Queensland University of Technology. This review addresses the rationale for implementation and integration in teaching environments and explores the pedagogical benefits supported by educational theory.

Discussion

A review of MOSAIQ functionality shows potential to transform learning through the development of authentic and engaging learning tasks. It provides students with an opportunity to learn two-dimensional image matching through the use of digitally reconstructed radiographs and electronic portal images as well as three-dimensional image matching using computed tomography (CBCT) data in a safe learning environment without clinical time pressures. In addition, this provides the students with knowledge of quality assurance (QA) checks through the verification of treatment parameters and the transfer of information from the planning system to the treatment units. However, there are several potential challenges and practical considerations that need to be overcome.

Conclusion

The application of MOSAIQ OIS could potentially transform teaching and learning strategies for student radiation therapists. Increased knowledge and hands-on skills at undergraduate levels in areas such as image matching and QA can be powerful tools to drive the standards of practice a step further.
Effect of LINAC-based postoperative radiotherapy on local control and survival in patients with non-small cell lung cancer
Authors: Cecen Sare , Yavuz Ali A. , Cecen Yigit , Duman Evrim , Ozdemir Beyza S. , Aksu Melek G.
Published: January 2017

Aim

To perform a retrospective analysis of survival, local–regional control and the effect of prognostic factors in 61 non-small cell lung cancer patients who were treated with postoperative radiotherapy (PORT) by a linear accelerator (LINAC).

Material and methods

A total of 50–66 Gy PORT with a fractional dose of 1·8–2 Gy was administered to 24 patients (24·5%) for surgical margin positivity, 33 patients (54%) for mediastinal lymph node involvement and 13 patients (21·5%) for both mediastinal lymph node involvement and positive surgical margins.

Results

Median follow-up was 17 months, and the median survival and median distant metastasis-free survival were 25 and 19 months, respectively. Local-regional progression was observed in 10 patients (16·4%). Treatment modality (2D/3D) (p=0·021), tumour size >4 cm (p=0·004), surgical margin positivity (p=0·001), and left lung localisation of the tumour (p≤0·05) were the prognostic factors in terms of survival.

Conclusions

A survey of the literature shows that, without PORT, local recurrence or progression rates increase while overall survival rates decrease. In this study, only patients with PORT are studied and the results show that the local progression and overall survival rates are comparable with literature of LINAC-based PORT. In the case of overall survival, 3D treatment shows better results than 2D treatment modality.
Preparation for the end of life and life completion during late-stage lung cancer: An exploratory analysis
Authors: Adorno Gail , Wallace Cara
Published: January 2017

Objective:

Our aim was to explore preparation for the end of life (EoL) and life closure among persons with advanced metastatic lung cancer. Understanding quality of life through the lens of preparation and completion is important since the trajectory of lung cancer can be relatively short, often leading to application of cancer-directed therapies near death without the opportunity for advance planning or palliative care. Clinical research is needed to understand the kinds of distress specific to older adults with advanced lung cancer that are amendable to palliative care interventions.

Method:

We employed an exploratory cross-sectional design to examine psychosocial and existential concerns among a purposive sample (N = 30) of advanced lung cancer patients using the “end-of-life preparation” and “life completion” subscales of the Quality of Life at the End of Life (QUAL–E) questionnaire. Nonparametric methods were employed to analyze preparation, completion, global quality of life (QoL), and the associations among depressive symptoms, preparation, completion, and global QoL.

Results:

Higher scores on life completion were associated with better global QoL, and with items related to transcendence, communicative acts, and interpersonal relationships demonstrating important contributions. The perception of being a future burden on family members was the greatest concern within the preparation domain. Depressive symptoms were not associated with preparation, completion, or global QoL.

Significance of Results:

Psychosocial and existential issues contribute to QoL at the EoL among older adults with late-stage lung cancer during cancer-directed therapy, concurrent care, and hospice. The role of preparation, especially self-perceived burden, merits further research early on in the oncological setting. The preparation and life completion subscales of the QUAL–E are feasible clinical tools for facilitating dyadic communication about sensitive topics in the palliative care setting.
Enhancing Selective Exposure to Health Messages and Health	Intentions
Authors: Hastall Matthias R. , Wagner Anna J. M.
Published: January 2017

Abstract. Insufficient message exposure is still a major obstacle for effective health communication activities, and little is known on how message features affect selective exposure and persuasion. This study examined the effects of two health message features, suggested susceptibility and gain–loss framing, on respondents’ selective exposure and subsequent health behavior intentions. Two personality traits, repression-sensitization and approach/avoidance motivation, were studied as moderators of the proposed relationships. An experimental 2 (suggested susceptibility: low vs. high) × 2 (gain–loss framing: gain- vs. loss-framed message) study was conducted. Participants browsed through an online health magazine while their message choices were unobtrusively logged. A subsequent online questionnaire assessed personality dispositions and behavioral intentions. High levels of message susceptibility increased both selective exposure to health messages and respondents’ motivation to engage in adaptive health behaviors. Gain–loss framing did not affect message exposure or behavioral intentions, with one exception: Avoidance-oriented low-anxious respondents selected more loss-framed than gain-framed articles for reading. Repression-sensitization and approach/avoidance motivation did not moderate health message effects, but partly influenced these measures directly or in combination. The number of articles to choose from was limited, and it is unclear to what extent the findings can be generalized to other, more familiar health topics. Emphasizing readers’ susceptibility to health threats appears very effective for increasing exposure to health messages and protective behavioral intentions. The effectiveness of gain–loss framing, by contrast, largely depends on moderating factors.
David A. Seekell Receives 2016 Science for Solutions Award
Authors:   AGU
Published: January 2017

David A. Seekell received the 2016 Science for Solutions Award at the American Geophysical Union Fall Meeting Honors Ceremony, held on 14 December 2016 in San Francisco, Calif. The award is for "significant contributions in the application and use of the Earth and space sciences to solve societal problems."
MECP2 regulates cortical plasticity underlying a learned behaviour in adult female mice
Authors: Krishnan Keerthi , Lau Billy Y. B. , Ewall Gabrielle , Huang Z. Josh , Shea Stephen D.
Published: January 2017

Neurodevelopmental disorders are marked by inappropriate synaptic connectivity early in life, but how disruption of experience-dependent plasticity contributes to cognitive and behavioural decline in adulthood is unclear. Here we show that pup gathering behaviour and associated auditory cortical plasticity are impaired in female Mecp2het mice, a model of Rett syndrome. In response to learned maternal experience, Mecp2het females exhibited transient changes to cortical inhibitory networks typically associated with limited plasticity. Averting these changes in Mecp2het through genetic or pharmacological manipulations targeting the GABAergic network restored gathering behaviour. We propose that pup gathering learning triggers a transient epoch of inhibitory plasticity in auditory cortex that is dysregulated in Mecp2het. In this window of heightened sensitivity to sensory and social cues, Mecp2 mutations suppress adult plasticity independently from their effects on early development.
Sixfold improved single particle measurement of the magnetic moment of the antiproton
Authors: Nagahama H. , Smorra C. , Sellner S. , Harrington J. , Higuchi T. , Borchert M. J. , Tanaka T. , Besirli M. , Mooser A. , Schneider G. , Blaum K. , Matsuda Y. , Ospelkaus C. , Quint W. , Walz J. , Yamazaki Y. , Ulmer S.
Published: January 2017

Our current understanding of the Universe comes, among others, from particle physics and cosmology. In particle physics an almost perfect symmetry between matter and antimatter exists. On cosmological scales, however, a striking matter/antimatter imbalance is observed. This contradiction inspires comparisons of the fundamental properties of particles and antiparticles with high precision. Here we report on a measurement of the g-factor of the antiproton with a fractional precision of 0.8 parts per million at 95% confidence level. Our value "Equation missing"/2=2.7928465(23) outperforms the previous best measurement by a factor of 6. The result is consistent with our proton g-factor measurement gp/2=2.792847350(9), and therefore agrees with the fundamental charge, parity, time (CPT) invariance of the Standard Model of particle physics. Additionally, our result improves coefficients of the standard model extension which discusses the sensitivity of experiments with respect to CPT violation by up to a factor of 20.
SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages
Authors: Luo Lin , Bokil Nilesh J. , Wall Adam A. , Kapetanovic Ronan , Lansdaal Natalie M. , Marceline Faustine , Burgess Belinda J. , Tong Samuel J. , Guo Zhong , Alexandrov Kirill , Ross Ian L. , Hibbs Margaret L. , Stow Jennifer L. , Sweet Matthew J.
Published: January 2017

Danger signals activate Toll-like receptors (TLRs), thereby initiating inflammatory responses. Canonical TLR signalling, via Toll/Interleukin-1 receptor domain (TIR)-containing adaptors and proinflammatory transcription factors such as NF-κB, occurs in many cell types; however, additional mechanisms are required for specificity of inflammatory responses in innate immune cells. Here we show that SCIMP, an immune-restricted, transmembrane adaptor protein (TRAP), promotes selective proinflammatory cytokine responses by direct modulation of TLR4. SCIMP is a non-TIR-containing adaptor, binding directly to the TLR4-TIR domain in response to lipopolysaccharide. In macrophages, SCIMP is constitutively associated with the Lyn tyrosine kinase, is required for tyrosine phosphorylation of TLR4, and facilitates TLR-inducible production of the proinflammatory cytokines IL-6 and IL-12p40. Point mutations in SCIMP abrogating TLR4 binding also prevent SCIMP-mediated cytokine production. SCIMP is, therefore, an immune-specific TLR adaptor that shapes host defence and inflammation.
An aposymbiotic primary coral polyp counteracts acidification by active pH regulation
Authors: Ohno Yoshikazu , Iguchi Akira , Shinzato Chuya , Inoue Mayuri , Suzuki Atsushi , Sakai Kazuhiko , Nakamura Takashi
Published: January 2017

Corals build their skeletons using extracellular calcifying fluid located in the tissue–skeleton interface. However, the mechanism by which corals control the transport of calcium and other ions from seawater and the mechanism of constant alkalization of calcifying fluid are largely unknown. To address these questions, we performed direct pH imaging at calcification sites (subcalicoblastic medium, SCM) to visualize active pH upregulation in live aposymbiotic primary coral polyps treated with HCl-acidified seawater. Active alkalization was observed in all individuals using vital staining method while the movement of HPTS and Alexa Fluor to SCM suggests that certain ions such as H+ could diffuse via a paracellular pathway to SCM. Among them, we discovered acid-induced oscillations in the pH of SCM (pHSCM), observed in 24% of polyps examined. In addition, we discovered acid-induced pH up-regulation waves in 21% of polyps examined, which propagated among SCMs after exposure to acidified seawater. Our results showed that corals can regulate pHSCM more dynamically than was previously believed. These observations will have important implications for determining how corals regulate pHSCM during calcification. We propose that corals can sense ambient seawater pH via their innate pH-sensitive systems and regulate pHSCM using several unknown pH-regulating ion transporters that coordinate with multicellular signaling occurring in coral tissue.
Targeting the PI3K/AKT pathway via GLI1 inhibition enhanced the drug sensitivity of acute myeloid leukemia cells
Authors: Liang Hui , Zheng Qi-Li , Fang Peng , Zhang Jian , Zhang Tuo , Liu Wei , Guo Min , Robinson Christopher L. , Chen Shui-bing , Chen Xiao-Ping , Chen Fang-Ping , Zeng Hui
Published: January 2017

Combination targeted therapy is commonly used to treat acute myeloid leukemia (AML) patients, particularly in refractory/relapse (RR) population. However, concerns have been raised regarding the safety and patient tolerance of combination chemotherapy. It is critical to choose the appropriate treatment for precision therapy. We performed genome-wide RNA profiling using RNA-Seq to compare the RR group and the complete remission (CR) group (a total of 42 adult AML patients). The Hedgehog (Hh) and PI3K/AKT pathways were upregulated in the RR population, which was further confirmed by western blot and/or qPCR. Overexpression of GLI1 in AML cells led to increased AKT phosphorylation and decreased drug sensitivity, which was attenuated by GLI1 inhibition. By contrast, neither the expression of GLI1 nor apoptosis in response to Ara-C treatment of AML cells was significantly affected by PI3K inhibition. Furthermore, co-inhibition of GLI1 and PI3K induced apoptosis of hematopoietic stem/progenitor cells (HSPCs), which raised serious concerns about the side effects of this treatment. These results indicated that GLI1 inhibition alone, but not combined inhibition, is sufficient to enhance AML drug sensitivity, which provides a novel therapeutic strategy for AML treatment.
Comorbid generalized anxiety disorder and its association with quality of life in patients with major depressive disorder
Authors: Zhou Yongjie , Cao Zhongqiang , Yang Mei , Xi Xiaoyan , Guo Yiyang , Fang Maosheng , Cheng Lijuan , Du Yukai
Published: January 2017

The comorbidity of major depressive disorder (MDD) and generalized anxiety disorder (GAD) is common and often predicts poorer outcomes than either disorder alone. This study aimed to examine the prevalence of comorbid GAD and its association with quality of life (QOL) among MDD patients. A total of 1225 psychiatric outpatients were screened using the Hospital Anxiety and Depression Scale (HADS). Those who scored ≥8 on the HADS were interviewed using DSM-IV criteria by two senior psychiatrists. Patients diagnosed with MDD were further assessed using the 9-item Patient Health Questionnaire, Social Support Rating Scale, Pittsburgh Sleep Quality Index, and World Health Organization QOL Scale, brief version (WHOQOL-BREF). Ultimately, 667 patients were diagnosed with MDD, of 71.7% of whom had GAD. Compared to those with MDD alone, comorbid patients had lower scores on the physical (38.64 ± 10.35 vs.36.54 ± 12.32, P = 0.026) and psychological (35.54 ± 12.98 vs. 30.61 ± 14.66, P < 0.001) domains of the WHOQOL-BREF. The association between comorbid GAD and poor QOL on the two domains remained statistically significant in the multiple linear regression (unstandardized coefficients: −1.97 and −4.65, P < 0.001). In conclusion, the prevalence of comorbid GAD in MDD patients is high, and co-occurring GAD may exacerbate impaired physical and psychological QOL in Chinese MDD patients.
An extended N-H bond, driven by a conserved second-order interaction, orients the flavin N5 orbital in cholesterol oxidase
Authors: Golden Emily , Yu Li-Juan , Meilleur Flora , Blakeley Matthew P. , Duff Anthony P. , Karton Amir , Vrielink Alice
Published: January 2017

The protein microenvironment surrounding the flavin cofactor in flavoenzymes is key to the efficiency and diversity of reactions catalysed by this class of enzymes. X-ray diffraction structures of oxidoreductase flavoenzymes have revealed recurrent features which facilitate catalysis, such as a hydrogen bond between a main chain nitrogen atom and the flavin redox center (N5). A neutron diffraction study of cholesterol oxidase has revealed an unusual elongated main chain nitrogen to hydrogen bond distance positioning the hydrogen atom towards the flavin N5 reactive center. Investigation of the structural features which could cause such an unusual occurrence revealed a positively charged lysine side chain, conserved in other flavin mediated oxidoreductases, in a second shell away from the FAD cofactor acting to polarize the peptide bond through interaction with the carbonyl oxygen atom. Double-hybrid density functional theory calculations confirm that this electrostatic arrangement affects the N-H bond length in the region of the flavin reactive center. We propose a novel second-order partial-charge interaction network which enables the correct orientation of the hydride receiving orbital of N5. The implications of these observations for flavin mediated redox chemistry are discussed.
Inferring Centrality from Network Snapshots
Authors: Shao Haibin , Mesbahi Mehran , Li Dewei , Xi Yugeng
Published: January 2017

The topology and dynamics of a complex network shape its functionality. However, the topologies of many large-scale networks are either unavailable or incomplete. Without the explicit knowledge of network topology, we show how the data generated from the network dynamics can be utilised to infer the tempo centrality, which is proposed to quantify the influence of nodes in a consensus network. We show that the tempo centrality can be used to construct an accurate estimate of both the propagation rate of influence exerted on consensus networks and the Kirchhoff index of the underlying graph. Moreover, the tempo centrality also encodes the disturbance rejection of nodes in a consensus network. Our findings provide an approach to infer the performance of a consensus network from its temporal data.