bluuebunny/crossref_metadata_2025 huggingface dataset:
ANALISIS FAKTOR YANG MEMPENGARUHI MINAT MAHASISWA BERINVESTASI DI PASAR MODAL SYARIAH (Studi kasus Universitas Syiah Kuala)
Authors: Farhul Muhammad , Amri Amri
Published: December 2024

Tujuan dari penelitian ini adalah untuk mengetahui apakah ada mahasiswa Universitas Syiah Kuala yang berpikir untuk menginvestasikan uang mereka di pasar modal Islam dan, jika demikian, apa peran media sosial, investasi minimum, dan tingkat pemahaman dalam keputusan mereka. Kumpulan data terdiri dari data primer dan sekunder, yang diperoleh dari berbagai sumber termasuk survei dan makalah terkait. Penelitian ini melibatkan seratus orang yang menggunakan rumus Slovin. Proses pengambilan sampel menggunakan metode pengambilan sampel bertingkat. Penelitian ini menggunakan beberapa metode regresi linier untuk menganalisis data. Pengetahuan, modal minimal, dan media sosial merupakan tiga karakteristik yang memiliki pengaruh paling baik dan substansial terhadap minat mahasiswa untuk terlibat dalam pasar modal Islam. Sehubungan dengan Sekuritas dan Bursa Efek Indonesia (BEI), yang bertujuan untuk meningkatkan jaringan dan pendidikan mahasiswa tentang partisipasi Islam di pasar modal. .Kata Kunci : Analisis,Minat Mahasiswa Berinvestasi, Pasar Modal Syariah.
THE INFLUENCE OF SHARIA FINANCIAL LITERACY CONSUMPTIVE CULTURE AND RELIGIOUSITY ON STUDENTS INTEREST IN SAVING
Authors: Ismuadi Ismuadi , Aulia Riza , Melinda Ulfa
Published: December 2024

Sharia financial literacy, consumer culture, and religiosity are factors that can influence students’ interest in saving. This research aims to determine the influence of sharia financial literacy, consumer culture and religiosity on students’ interest in saving in the city of Banda Aceh. This research uses quantitative methods. The population in this study were students receiving the 2023 Bank Indonesia Scholarship in Banda Aceh City with a sample size of 143 respondents by distributing questionnaires via Google Form. The data was analyzed using multiple linear regression using SPSS 25. The results of this study showed that sharia financial literacy had a positive and significant effect on students’ interest in saving, consumer culture had a negative effect on students’ interest in saving, and religiosity had a significant positive effect on student’ interest in saving. However, these three independent variables simultaneously influence the savings interest of students receiving Bank Indonesia Scholarshipsin Banda Aceh City.
Training on Management Control System in Printing Entrepreneurs
Authors: Abd Karim Mohd Rahimie bin , Lada Suddin , Halim Hendra , Kesuma T. Meldi , Siregar M. Ridha , Riyaldi Muhammad Haris , Nizam Ahmad , Majid M Shabri Abd , Dawood Taufiq Carnegie , Priantana Riha Dedi , Sakir A , Sari Meutia Dwi Novita , Amir Fakhrurrazi
Published: December 2024

This community service activity aimed to improve the management control systems of print entrepreneurs around Universitas Syiah Kuala (USK). The main issue was the lack of understanding and implementation of effective control systems, leading to operational inefficiencies. Using a Service Learning approach, 10 entrepreneurs participated in training led by experts from Universiti Malaysia Sabah (UMS) and USK. The training covered management control concepts and introduced basic technology tools to support business operations. Results showed a 25% increase in participants' understanding of management control systems and an 85% adoption rate of the techniques and technologies introduced. These improvements contributed to better business efficiency and align with Sustainable Development Goal 8, which emphasizes decent work and economic growth. This activity demonstrated that tailored training programs can significantly enhance small business operations and can be replicated for broader impact.
Training to Build a Creative and Innovative Young Entrepreneur Mindset
Authors: Hanidah In-In , Halim Hendra , Fadhil Rahmat , Kesuma T. Meldi , Siregar M. Ridha , Ramadhani Evi , Ginting Ledy Mahara , Najla Najla , Fakhrurrazi Fakhrurrazi , Rahimi Sayyid Afdhal El , Zikran Ghrina
Published: December 2024

The community service activity Training to Build a Creative and Innovative Entrepreneurial Mindset for Young Entrepreneurs aimed to enhance innovation and creativity among beginner entrepreneurs in Banda Aceh. The program involved 100 participants and was conducted using the service learning method, which included practical sessions, group discussions, and business simulations. Pre-test and post-test evaluations showed an average improvement of 40% in understanding innovation concepts, technology adoption, and strategic business planning. Despite challenges such as limited digital infrastructure, the results demonstrated that participants were able to develop innovation-driven business plans. This program contributes to achieving the SDGs, particularly in the areas of decent work and economic growth, as well as industry, innovation, and infrastructure. It is hoped that this activity can serve as a model for future community service programs focused on entrepreneurial development.
ESG Factors, Returns and Volatility: A Tale From Brazilian Market Data
Authors: Farias Camila Guedes de , Almeida Vinicio de Souza e
Published: December 2024

Objective: This study aims to investigate the relationship between Environmental, Social, and Governance (ESG) factors and financial market performance in Brazil. The objective is to understand the impact of ESG scores on firms’ returns and risk profiles, thereby informing investment strategies and policy decisions.
 
Theoretical Framework: The research is grounded in theories of sustainable finance and risk management, with emphasis on how ESG integration can influence financial outcomes. Notable frameworks include Cochrane’s “factor zoo” and the role of investor attention and analyst coverage in mitigating crash risk.
 
Method: Data for the study was obtained from the Refinitiv Eikon database, covering firm-level ESG characteristics and market data, such as returns and volatility. Ordinary least squares (OLS) regression was used to analyze cross-sectional data, exploring the relationship between ESG scores and financial performance metrics across various sectors.
 
Results and Discussion: The results show no significant relationship between returns and ESG scores. However, a negative and statistically significant relationship was found between ESG scores and volatility, suggesting that firms with higher ESG ratings tend to exhibit lower risk. ESG Controversies Score (ECSC) displayed negative correlations with other ESG metrics, indicating that companies involved in controversies tend to have lower overall ESG scores.
 
Research Implications: These findings suggest that while ESG scores may not directly influence returns, they play a role in risk management, highlighting the importance of ESG factors for investors seeking lower-risk profiles.
 
Originality/Value: This research contributes to the understanding of ESG’s role in the Brazilian market, offering empirical evidence on how ESG integration can shape financial performance and risk, providing a nuanced view of ESG’s impact on investment decisions.
UPOREDNA ANALIZA AI ALATA ZA GENERISANJE UI/UX ELEMENATA
Authors: Pantić Kristina
Published: December 2024

Cilj rada je pružiti dublje razumevanje uticaja i potencijala AI alata u oblasti UX dizajna. Istraživački deo rada prikazuje komparativnu analizu tri AI alata kroz generisanje prototipova veb sajta i mobilne aplikacije pomoću ovih alata, uz evaluaciju njihovih mogućnosti i ograničenja. Zaključci ukazuju na prednosti kao što su ubrzanje procesa i personalizacija, ali i na izazove kao što su ograničena prilagodljivost i ograničena detaljnost ulaznih parametara.
Impact Of Brand Identity, Halal Awareness On Purchasing Decisions With Promotional Interventions
Authors: Suci Pertiwi  , Nasrul Efendi  , Tya Wildana Hapsari Lubis  , Pioner Pelawi
Published: December 2024

This research aims to determine the influence of brand identity and halal awareness on purchasing decisions, with promotion as an intervening variable. The population includes people who consume imported instant noodles. Using convenience sampling and the Lameshow formula, 96 respondents were surveyed. The hypothesis tests show that brand identity positively affects purchasing decisions, while halal awareness does not. Additionally, promotion does not impact purchasing decisions, but brand identity positively influences promotion. Indirectly, brand identity and halal awareness do not affect purchasing decisions through promotion. The adjusted R square value for purchasing decisions is 0.755, indicating that 75.500 per cent of the variation in purchasing decisions is explained by the independent variables, with 24.500 per cent influenced by other factors not studied.
Tourism's Economic Impact in West Southeast Nusa: Input-Output Analysis Approach
Authors: Achmad Fioren Jati Golo  , Eris Girasto  , Rummana Labista Syahla Dewi  , Salma Nabila Asrizal
Published: December 2024

West Southeast Nusa has great tourism potential that should be developed to boost the macro economy which leads to increased community welfare. This study uses IO analysis to see the multiplier effect and the total effect of the tourism sector’s impact on output, employment, and income. The results show that the tourism sector is one of the key sectors in the economy of West Southeast Nusa Province, significantly increasing output, employment, and income. The large contribution of the tourism sector to the West Southeast Nusa economy should be a special concern for the government. Digitalization and investment in tourism sector and human resources must be increased to unleash the full potential of this sector and significantly boost the economy in West Southeast Nusa Province.
Estereótipos sobre a docência em conteúdos humorísticos
Authors: Da Silva Frazão Lucenir , Sá Luciana Passos
Published: December 2024

O artigo discute a construção e a manutenção de estereótipos acerca da docência em conteúdos humorísticos veiculados na mídia, com foco no vídeo Tipos de professores do comediante Diogo Almeida, disponível na plataforma YouTube. Na análise utilizou-se a metodologia denominada Etnografia de Tela, que envolve observação e interpretação de conteúdos audiovisuais, tendo em vista a compreensão de fenômenos culturais e sociais. O estudo destaca o modo como determinados estereótipos carregam marcas da colonialidade perpetuando desigualdades sociais e de gênero. Os resultados apontam para a predominância de representações negativas do trabalho docente, que contribuem para a desvalorização da profissão e reforçam ideias de desigualdades e relações de poder já tão enraizadas no imaginário popular.
Factors Affecting Career Choices of Students in Private High Schools in Ho Chi Minh City
Authors: Dat Truong Tan , Giang Tran Quoc
Published: December 2024

This article comprehensively examines the factors influencing career decisions of students in private high schools in Ho Chi Minh City. Using both qualitative and quantitative research methods, the study reveals that students' career choices are shaped by personal factors, such as passion, self-assessment abilities, independence, and are strongly influenced by family, school, and social environment. The family plays a crucial role in providing guidance and financial support, enabling students to pursue desired career paths. Schools, through career counseling programs and extracurricular activities, offer opportunities for students to explore and gain a deeper understanding of the requirements of various professions. The social environment, especially the influence of media and peers, contributes to shaping career role models and industry trends. The study also indicates that in a growing economy, students increasingly consider factors such as salary, employment opportunities, and career growth potential. Consequently, the article proposes support strategies involving families, schools, and the community to foster sustainable career orientation for students, aligning with the demands of the modern labor market.
DUALISME MANUSIA DALAM LONTAR TUTUR BHAGAWAN ANGGASTYA PRANA
Authors: Wardana I Ketut , Wariati Ni Luh Gede , Astiti Ni Wayan Sri
Published: December 2024

Lontar Bhagawan Anggastya Prana merupakan salah satu Lontar yang bersifat Sivaistik dimana Tuhan Siwa memiliki kedudukan tertinggi dan merupakan asal mula dari penciptaan manusia (Bhuwana Alit) yang disebut dengan Sang Hyang Siwatman. Lontar Bhagawan Anggastya Prana memiliki keunikan tersendiri dari beberapa Lontar-Lontar lainnya di Bali. Lontar ini menjelaskan proses penciptaan manusia serta penempatan aksara-aksara suci yang terdapat pada tubuh manusia beserta Ista Dewata yang menguasainya sebagai ajaran dalam upaya untuk mencapai kelepasan (Moksa). Oleh karena itu, penting untuk menggali kembali konsep dualisme manusia menurut Tutur Bhagawan Anggasta Prana. Penelitian ini tergolong jenis penelitian kualitatif dimana data primer atau data utama yang digunakan dalam penelitian yakni Lontar Bhagawan Anggastya Prana yang bersumber dari Lontar Bhagawan Anggastya Prana koleksi UPD Pusat dokumentasi Kebudayaan Bali.
Dualisme manusia dalam Tutur Bhagawan Anggasta Prana menyentuh inti dari ajaran spiritual mengenai sifat ganda atau dualitas yang ada dalam diri manusia. Dalam konteks teks ini, dualisme manusia digambarkan sebagai dua aspek utama yang membentuk keberadaan manusia, yaitu aspek fisik (stula sarira) dan aspek spiritual atau roh (suksma sarira). Berdasarkan analisis terhadap Lontar Tutur Bhagawan Anggastya Pranā maka dapat diketahui bahwa Jiwa (atman) perwujudan dari Sang Hyang Śiwatma.  Manusia dijiwai Dewa, Kala dan Atma. Unsur-unsur Badan merupakan anugrah para Dewa yang akhirnya semua menyatu menjadi sebuah keutuhan yaitu badan. Aksara Suci dalam Tubuh Manusia merupakan Manifestasi Sang Hyang Widhi.
Hydrogeological and hydrochemical study of groundwater aquifer in Wasit Governorate, Eastern Iraq
Authors: Al-Sudani Hussein Ilaibi Zamil
Published: December 2024

The main aim of groundwater studies is to assess the physical and chemical characterizations of water-bearing layers as a goal for assessing their suitability for various purposes Wasit Governorate, which is located in eastern Iraq, is an important area in terms of agriculture and poultry and livestock husbandry. The area mainly depends on groundwater, especially on the Iraqi-Iranian border. The area was investigated (40) wells inventoried during the field study and used to demonstrate the hydrogeological and hydrochemical properties. The groundwater aquifer is composed of Quaternary deposits and Mukdadiyah formation. The mean thickness, transmissivity, and maximum yields were 53 meters, 114 m2/day, and 600 m3/day, respectively. The groundwater moved partially to the western parts and mainly towards the southern parts of the area towards Shuwaicha Marsh, which is located outside the study area. The salinity map showed a regular decrease in salinity concentrations towards the central and southwestern parts of the area due to groundwater recharge from infiltrated surface water. The groundwater is brackish to saline, with two dominant calcium and sodium sulphate types. The central area between Zurbatia and Badra towns can be a qualified location to increase well drilling due to salinity decreasing as the transmissivity and maximum yields increase.
An Analysis of Shot Types and Camera Angles in the Feature News "Transforming Scrap Fabric into Artwork" on the TVRI Jawa Barat News Program
Authors: Firman Kania Nurrahmi , Nugroho David Rizar
Published: December 2024

"Transforming Scrap Fabric into Artwork" is one of the travel feature news segments aired on the TVRI Jawa Barat program, Jawa Barat Hari Ini (West Java Today). The primary focus of the feature news video is on the objects and locations of the tourist village being covered. The selection of appropriate filming techniques ensures that the information conveyed in the travel feature news is clear and effective for the audience. Therefore, it is essential to choose the right filming techniques to effectively highlight the uniqueness and inspirational story of Kampung Perca (Scrap Fabric Village). This research aims to analyze the filming techniques used in a feature news video, focusing on shot types and camera angles. Data collection methods include observation, interviews, and literature review. The data is analyzed through data reduction, data presentation, data validity testing, and conclusion drawing and verification. The shot types in the feature news video include six categories: wide shot/long shot, medium close-up, medium shot, close-up, big close-up, and over-the-shoulder shot. The camera angles used in the feature news video consist of three categories: high angle, low angle, and eye level.
Keywords: angle camera; feature news; filming techniques; shot type.
Love For Sale: Virtual Lovers Rental Services in Indonesia
Authors: Louwbry Anastasya , Girsang Lasmery RM
Published: December 2024

The way interpersonal relationships, particularly romantic ones, are formed has gradually transitioned to the virtual realm. Digital communication media now serve as platforms where users can meet and establish relationships without the constraints of physical distance and face-to-face interactions. The phenomenon of Virtual Lovers, originating in China, explains how individuals offer services as virtual partners to accompany clients. This relationship can be understood through the concept of Mediated Relationship, where romantic relationships flourish without contextual limitations, using digital communication as the primary medium. This study aims to explore the virtual communication process and interpersonal relationships of a Virtual Lover in their profession. Using a constructivist paradigm and a qualitative approach, this study aims to examine the experiences and values of Virtual Lovers in situational romantic interactions with their clients. It was found that a Virtual Lover communicates with their client in a situational romantic relationship, engaging in conversations or sharing stories about life’s problems. Virtual Lovers create a self-profile reflecting how they wish to be perceived through virtual communication. This exchange of information builds familiarity and trust as their knowledge of each other deepens. Despite not meeting face-to-face, Virtual Lovers feel their persona as a talent is distinct from their real-life self, where talent must listen attentively and adapt to the needs of their clients. Agencies acting as intermediaries between clients and talents enforce various regulations to protect the privacy and security of all parties involved.
Енергоефективні гібридні сонячні колектори інтегровані у світлопрозорі конструкції будівель
Authors:   Національний університет “Львівська політехніка”, Шаповал Степан , Пришляк Юрій ,   Національний університет “Львівська політехніка”, Гулай Богдан ,   Національний університет “Львівська політехніка”, Генсецький Микола ,   Національний університет “Львівська політехніка”, Касинець Мар’яна ,   Національний університет “Львівська політехніка”
Published: December 2024

Одним із ключових завдань в сучасній енергетиці є забезпечення теплом енергоефективних будівель за допомогою відновлюваних джерел енергії, зокрема сонячної енергії. Через обмежений простір для розміщення геліоколекторів на будівлях, перспективною є інтеграція сонячних систем теплопостачання в конструкції зовнішніх огороджень будівель. У цій статті розглянуто наукові аспекти застосування основних типів сонячних колекторів, а також їх класифікацію. Авторами запропонована конструкція гібридного теплового та фотоелектричного сонячного колектора й подана методика розрахунку теплових характеристик системи теплопостачання з використанням такого геліоколектора. У статті наведено аналіз розрахунку теплових процесів у гібридних сонячних колекторах, які інтегровані у світлопрозорі фасади будівель і споруд. Тут особлива увага зосереджена на визначенні коефіцієнта корисної дії такого пристрою. Дані, представлені у статті, показують, що математична модель процесів теплообміну в гібридному геліоколекторі потребує додаткових експериментальних досліджень.
The Position of the Police Code of Ethics Commission in The Judicial Power System in Indonesia
Authors: Warsyim Yusuf , Harmoko Harmoko
Published: December 2024

The Police Code of Ethics Commission has the authority to advocate violations of the Police Code of Ethics. The presence of the National Police Code of Ethics Commission gave rise to serious conceptual debates. As a rule of law with an independent judicial power as its main element, theoretically, judicial power can only be owned by state institutions that are constitutionally recognized in the 1945 Constitution, namely the Supreme Court and the Constitutional Court, but in its development, the function of Judicial power is not only exercised by the courts. This study aims to determine the position of the Polri Code of Ethics Commission and the relationship between the Polri Code of Ethics Commission and the judicial power system in Indonesia. The method used is normative research, with a conceptual approach and laws and regulations. The results of the study found that the position of the Polri Code of Ethics Commission in the judicial power system has been accommodated in the Judicial Power Law, and the relationship that is built between the Code of Ethics Commission and the Supreme Court is a functional relationship.
Synthesis of Silver Nanoparticles using Streptomyces variabilis MGR21: Characterization, Cytotoxicity and Photocatalytic Applications
Authors: Gomathi Manoharan , Suresh Kumarasamy , Muthusamy Ranganathan
Published: December 2024

The present work mainly focused on developing an eco-friendly, rapid methodology for synthesizing AgNPs using Streptomyces variabilis MGR21 and validating the synthesized AgNPs by UV–Vis spectroscopy which provides information about absorption spectra, FTIR for functional group determination, XRD for crystallinity determination, SEM, for size determination of the particles and X-ray nanotracking for purity. Similarly, the anti-proliferative effect of AgNPs against cultured L6 cell lines grown in the studies showed a view that the biosynthesis of AgNPs inhibits the growth of cancer cells as compared to the control cell line. UV-Vis absorption confirmed the presence of Ag Nps with a spectrum observed at 420 nm. Functional groups in synthesized Ag NPs are shifted to 3424.63 cm-1, confirmed using an FT-IR spectrum. Consequently, the anti-cancer efficacy for As Ag NPs against L6 cells was observed to have an IC50 value of 10.0 μg/mL for 48 h.

Finally, in the AgNPs studies, photocatalytic degradation against the radioactive dye methylene blue was explored by a halogen lamp and resulted in a degradation rate of 92 percent in 90 minutes. The silver nanoparticles mediated by Streptomyces variabilis MGR21 exhibit improved photodegradation of methylene blue dye under solar light. Therefore, it has broad potential applications in the sphere of wastewater treatment. Overall, silver nanoparticles biosynthesized in the present study showed excellent cytotoxic, actinobacteriocidal and photocatalytic dye degradation effects.
Friedel-Crafts reaction with polyolefins as alkylation reagents and poly(vinyl chloride) as initiator
Authors: Tan Xinyue , Yang Yizhou , Li Zhen Hua , Wang Huadong
Published: December 2024

Transformation of waste plastics into high-value chemicals provides an important solution to mitigate their huge impact on the environment. Polyolefins, including polyethylene and polypropylene, two most produced plastics, are composed of long-chain alkanes and can be potentially applied as alkylation reagents for organic transformations. In this work, we demonstrated that aluminum trichloride in the combination of poly(vinyl chloride), the third most produced and one of the least recycled plastic, can mediate Friedel-Crafts reaction of benzene with polyethylene, polypropylene or the mixture of the two as alkylation reagents. The reaction takes place under mild conditions, selectively producing toluene, ethylbenzene, cumene and n-propylbenzene. As the two major alkylbenzene products, ethylbenzene and cumene, are traditionally produced with ethylene or propene as alkylation reagent, this protocol shows the potential of polyolefins as surrogates for small olefins in organic transformations, offering new opportunities in a sustainable circular economy.
Enzyme enhancement through computational stability design targeting NMR-determined catalytic hotspots
Authors: Gutierrez-Rus Luis I. , Vos Eva , Pantoja-Uceda David , Hoffka Gyula , Gutierrez-Cardenas Jose , Ortega-Muñoz Mariano , Risso Valeria A. , Angeles Jimenez Maria , Kamerlin Shina Caroline Lynn , Sanchez Ruiz Jose M.
Published: December 2024

Enzymes are the quintessential green catalysts, but realizing their full potential for biotechnology typically requires improvement of their biomolecular properties. Catalysis enhancement, however, is often accompanied by impaired stability. Here, we show how the interplay between activity and stability in enzyme optimization can be efficiently addressed by coupling two recently proposed methodologies for guiding directed evolution. We first identify catalytic hotspots from chemical shift perturbations induced by transition-state-analogue binding and then use computational/phylogenetic design (FuncLib) to predict stabilizing combinations of mutations at sets of such hotspots. We test this approach on a previously designed de novo Kemp eliminase, which is already highly optimized in terms of both activity and stability. Most tested variants displayed substantially increased denaturation temperatures and purification yields. Notably, our most efficient engineered variant shows a ~3-fold enhancement in activity (kcat 1700 s-1, kcat/KM 4.3·105 M-1s-1) from an already heavily optimized starting variant, resulting in the most proficient proton-abstraction Kemp eliminase designed to date, with a catalytic efficiency on a par with naturally occurring enzymes. Molecular simulations pinpoint the origin of this catalytic enhancement as being due to the progressive elimination of a catalytically inefficient substrate conformation that is present in the original design. Remarkably, interaction network analysis identifies a significant fraction of catalytic hot-spots, thus providing a computational tool which we show to be useful even for natural-enzyme engineering. Overall, our work showcases the power of dynamically guided enzyme engineering as a design principle for obtaining novel biocatalysts with tailored physicochemical properties, towards even anthropogenic reactions.
Interlayer expansion of hydrogen titanate anodes improves electrochemical Na+ intercalation kinetics and reversibility
Authors: Elmanzalawy Mennatalla , Tobis Maciej , Tsai Wan-Yu , Fleischmann Simon
Published: December 2024

Hydrogen tetratitanates (H2Ti4O9, HTO) are synthesized and studied as anode materials for sodium-ion batteries. Using n-propylamine molecular pillars, the interlayer spacing of HTO is increased from 0.86 to 1.58 nm. The electrochemical Na+ intercalation properties of pristine and interlayer-expanded HTOs are studied with detailed electrochemical characterization and operando electrochemical dilatometry experiments. Interlayer-expansion results in higher maximum sodiation capacity and improved kinetics and electrochemical reversibility.
Inhibition of Subunit Exchange and N-Finger Rearrangement in SARS-CoV-2 Main Protease by Peptidomimetic Inhibitors
Authors: Kuo Syuan-Ting , Xi Zhenyu , Sheng Yan , Xu Shiqing , Liu Wenshe , Russell David. H. , Yan Xin
Published: December 2024

The main protease (Mpro) of SARS-CoV-2 is an essential enzyme for viral replication, making it a critical target for antiviral drug development. While current Mpro inhibitors, such as Paxlovid, focus on active site binding, resistance mutations are emerging, underscoring the need for alternative strategies. Dimerization of Mpro, necessary for its enzymatic activity, presents a promising but underexplored target for drug development. However, knowledge gaps remain in understanding the dynamic conformational changes and network of residues that stabilize the dimer interface. In this study, we captured the transient dynamics of Mpro dimerization and the conformational changes at the dimer interface induced by inhibitor binding. Integrat-ing stable isotope labeling and native mass spectrometry with hydrogen-deuterium exchange, we provided time-resolved insights into the structural dynamics of Mpro in its intact dimeric form. We employed N15 isotopic labeling of Mpro to investi-gate subunit exchange and dissociation kinetics during dimerization, both in the presence and absence of peptidomimetic inhibitors, including Nirmatrelvir, GC376, and MPI8. Our findings revealed that peptidomimetic inhibitor binding inhibited dimer dissociation, altering the dynamics of subunit exchange. Moreover, we identified significant conformational changes across Mpro's three domains and at the dimer interface upon inhibitor binding. Notably, hydrogen-deuterium exchange pro-files transitioned from bimodal to unimodal distributions in the N-finger region when Mpro was complexed with Nirmatrelvir, suggesting distinct structural alterations that stabilize the dimeric form. By filling critical knowledge gaps in the understand-ing of Mpro dimerization and its inhibitor-induced dynamics, our study provides a foundation for the rational design of next-generation Mpro inhibitors targeting the dimer interface.
Explainable Synthesizability Prediction of Inorganic Crystal Polymorphs using Large Language Models
Authors: Kim Seongmin , Schrier Joshua , Jung Yousung
Published: December 2024

We evaluate the ability of machine learning to predict whether a hypothetical crystal structure can be synthesized and explain those predictions to scientists. Fine-tuned large language models (LLMs) trained on a human-readable text description of the target crystal structure perform comparably to previous bespoke convolutional graph neural network methods, but better prediction quality can be achieved by training a positive-unlabeled learning model on a text-embedding representation of the structure. An LLM-based workflow can then be used to generate human-readable explanations for the types of factors governing synthesizability, extract the underlying physical rules, and assess the veracity of those rules. These explanations can guide chemists in modifying or optimizing non-synthesizable hypothetical structures to make them more feasible for materials design.
Robust Automated Truncation Point Selection for Molecular Simulations
Authors: Clark Finlay , Cole Daniel , Michel Julien
Published: December 2024

Quantities calculated from molecular simulations are often subject to an initial bias due to unrepresentative starting configurations. Initial data are usually discarded to reduce bias. Chodera's method for automated truncation point selection [J. Chem. Theory Comput. 2016, 12, 4, 1799–1805] is popular but has not been thoroughly assessed. We reformulate White’s marginal standard error rule to provide a spectrum of truncation point selection heuristics that differ in their treatment of autocorrelation. These include a method effectively equivalent to Chodera's. We test these methods on ensembles of synthetic time series modelled on free energy change estimates from long absolute binding free energy calculations. Methods that more thoroughly account for autocorrelation often show late and variable truncation times, while methods that less thoroughly account for autocorrelation often show early truncation, relative to the optimal truncation point. This increases variance and bias, respectively. We recommend a method that achieves robust performance across our test sets by balancing these two extremes. None of the methods reliably detected insufficient sampling. All heuristics tested are implemented in the open-source Python package RED (https://github.com/fjclark/red).
Open-source and FAIR Research Software for Proteomics
Authors: Perez-Riverol Yasset , Bittremieux Wout , Noble William S. , Martens Lennart , Bilbao Aivett , Lazear Michael R. , Grüning Bjorn , Katz Daniel S. , MacCoss Michael J. , Dai Chengxin , Eng Jimmy K. , Bouwmeester Robbin , Shortreed Michael Robert , Audain Enrique , Sachsenberg Timo , Van Goey Jeroen , Wallmann Georg , Wen Bo , Käll Lukas , Fondrie William E.
Published: December 2024

Scientific discovery relies on innovative software as much as experimental methods, especially in proteomics, where computational tools are essential for mass spectrometer setup, data analysis, and interpretation. Since the introduction of SEQUEST, proteomics software has grown into a complex ecosystem of algorithms, predictive models, and workflows, but the field faces challenges, including the increasing complexity of mass spectrometry data, limited reproducibility due to proprietary software, and difficulties integrating with other omics disciplines. Closed-source, platform-specific tools exacerbate these issues by restricting innovation, creating inefficiencies, and imposing hidden costs on the community. Open-source software (OSS), aligned with the FAIR Principles (Findable, Accessible, Interoperable, Reusable), offers a solution by promoting transparency, reproducibility, and community-driven development, which fosters collaboration and continuous improvement. In this manuscript, we explore the role of OSS in computational proteomics, its alignment with FAIR principles, and its potential to address challenges related to licensing, distribution, and standardization. Drawing on lessons from other omics fields, we present a vision for a future where OSS and FAIR principles underpin a transparent, accessible, and innovative proteomics community.
Raconter la chasse. Territoire et communauté dans La foi du braconnier (2009) de Marc Séguin et La bête lumineuse (1982) de Pierre Perrault
Authors: Guay-Poliquin Christian
Published: December 2024

La chasse et la narration sont des activités qui remontent aux origines de l’humanité. Ainsi, on retrouve des récits de chasse aussi loin que la documentation archéologique nous permet de remonter. Or, il est important de souligner que la chasse, dans les arts narratifs, servait souvent à raconter autre chose que la chasse elle-même. La portée symbolique de ses composantes, sa dimension métaphorique, son rapport à l’animal et à la nature ont contribué, au fil des époques, à la structuration de différents discours, qu’ils soient cosmologiques, hiérarchiques ou critiques. À partir de ce puissant maillage historique, cet article vise à cerner comment le roman La foi du braconnier (2009) de Marc Séguin et le long métrage La bête lumineuse (1982) de Pierre Perrault mobilisent la thématique cynégétique, profondément inscrite dans la tradition, afin de mettre en scène différentes problématiques contemporaines, notamment par rapport au territoire et à la communauté.
« Autant gibier que chasseur ». Métamorphose(s) et éthique dans Un dieu chasseur (1976) de Jean-Yves Soucy
Authors: Defraeye Julien
Published: December 2024

En 1976, Jean-Yves Soucy, alors « inconnu pour les lettres québécoises » (Poulin), reçoit le prix de la revue Études françaises pour son premier roman, Un dieu chasseur. Alors que les productions littéraires s’étaient graduellement tournées vers la ville depuis le milieu du siècle, le roman de Soucy se présente à sa publication comme un « anachronisme » pour une partie de la critique, puisque celui-ci met en scène Mathieu Bouchard, un chasseur aguerri vivant seul avec ses chiens dans la forêt, au Nord de Mont-Laurier. Dans le même temps, dans sa pratique quasi-quotidienne de la chasse, le protagoniste de Soucy partage certaines réflexions éthiques sur le rapport de l’homme à l’altérité animale pouvant être considérées comme avant-gardistes au milieu des années 1970. D’un point de vue historico-littéraire, le roman de Soucy se lit donc à la fois comme une possible résurgence du terroir québécois et un précurseur du récent regain d’intérêt pour le récit de chasse.
« Il y a une très grande douceur dans la chasse ». Entretien avec Mireille Gagné sur Le lièvre d’Amérique (2020)
Authors: Gagné Mireille , Defraeye Julien
Published: December 2024

Romancière, nouvelliste et poète, Mireille Gagné est née à l’Isle-aux-Grues et vit à Québec. Elle a publié cinq recueils de poésie et deux recueils de nouvelles. Grâce à son premier roman Le lièvre d’Amérique (La Peuplade, 2020), elle est notamment lauréate d’« Une ville, un livre » 2021, lauréate du Prix de création littéraire 2021 du Salon international du livre de Québec et de la Ville de Québec, finaliste du Prix Les Inrockuptibles catégorie « Premier roman », finaliste du Prix Wepler – Fondation La Poste, première sélection 2021 du Prix des libraires du Québec et Mention spéciale du jury du Prix Senghor. Elle vient de publier un second roman intitulé Frappabord (La Peuplade, 2024).
L’entretien ici transcrit et édité a été réalisé le 8 novembre 2023 à Québec, dans le cadre du projet de recherche « Éthique et esthétique dans le récit de chasse québécois contemporain (2000-présent) », financé par une subvention de développement Savoir (#430-2022-0435) du Conseil de Recherche en Sciences Humaines (CRSH). Nous remercions l’assistant de recherche James Brennan qui a préparé les recherches en amont de cet entretien et assuré le soutien technique permettant son bon déroulement.
Les souvenirs de voyage de Jeanne Bellonie Bourdaret : l’écriture féminine et l’exploration de l’Orient à la fin du dix-neuvième siècle
Authors: Boucher François-Emmanuël
Published: December 2024

Publiés par la Librairie Hachette, les récits de voyage de Jeanne Bellonie Bourdaret – À travers l’Arménie russe (1891 ; 1892), En Asie mineure, souvenirs de voyages en Cappadoce (1896) et En Asie mineure : Cilicie (1898) – forment un contraste avec ceux rédigés par le savant Ernest Chantre à la suite de leur expédition commune au Caucase, en Cappadoce et en Cilicie. L’article examine l’espace narratif de l’écriture de voyage au féminin, espace considéré à l’époque comme subalterne et secondaire, et s’interroge sur les raisons qui expliquent l’un des paradoxes produit par la postérité sur la valeur accordée aux récits des couples voyageurs du dix-neuvième siècle, soit l’intérêt grandissant pour les écrits dits féminins et le discrédit que connaissent de nos jours de nombreuses théories produites par les érudits férus de craniologie à une époque où l’impérialisme européen connait son apogée.
Voyageuses et féminisme(s) : les Notes d’une voyageuse en Turquie (1910) de Marcelle Tinayre
Authors: Irvine Margot
Published: December 2024

Cet article propose une analyse des Notes d’une voyageuse en Turquie (1910) de Marcelle Tinayre afin de montrer comment ce récit de voyage participe au discours féministe français du début du vingtième siècle. En mettant en valeur les capacités des Françaises, favorisées par les privilèges de l’impérialisme, Tinayre souligne ce dont elles sont capables. Grâce à ce récit de voyage, Tinayre acquiert aussi une plus grande légitimité dans sa carrière de femme de lettres.
Optimization of orange-fleshed sweet potato (SG 18-88-01) flour preparation for
maximum carotenoid retention using response surface methodology
Authors: Remigio K.T. , Avorque F.D. , Ancheta L.B. , Santiago D.O. , Galang M.B. , Sumague M.V. , Felismino R.M. , Abustan M.M. , Crisostomo S.D. , Villavicencio M.H.
Published: December 2024

Due to the nature of the flour processing methods, the nutritional content of sweet
potatoes decreases. Knowing the optimal flour processing conditions is important to
maximize the nutrition that one can obtain from sweet potato flour. In this study,
optimized flour preparation conditions for maximum β-carotene retention of orangefleshed sweet potato (SG 18-88-01) (OFSP) were determined using response surface
methodology. A two-level randomized Box-Behnken design was utilized to assess the
effects of blanching temperature (60 to 100°C), blanching time (1 to 3 mins), and drying
temperature (50 to 70°C). The optimal conditions were blanching for one minute at 97.75°
C and drying at 66.30°C. Using the said conditions, the experimental vitamin A content
was reported to be 373.95 IU/g, antioxidant activity was 0.55 mg TE/g, and color values
were 82.81 L*, 6.40 a*, 24.92 b*, and 1.32 radians hue angle. The predicted and
experimental values were compared using paired t-test and showed no significant
differences at p>0.05 and p>0.01. Hence, the model was adequate and had good predicting
capacity. The optimized OFSP flour has 5.50±0.80% moisture, 2.14±0.22% ash,
2.51±0.24% crude protein, 3.07±0.09% crude fiber, 0.47±0.03% crude fat, and 86.31%
nitrogen-free extract content. The flour has a water absorption index (WAI) of 5.90±0.15
g/g, water solubility index (WSI) of 55.26±0.03%, and swelling power of 13.23±1.34 g/g.
Given the results, the generated OFSP flour is ideal to use for food production,
particularly in bakery products. It was also revealed that consuming 4-10 g of the flour can
meet the Recommended Nutrient Intake in all Filipino age groups.
Characteristics of composite edible films from sago starch and gelatin
Authors: Picauly P. , Breemer R. , Rupilu R. , Polnaya F.J. , Ega L.
Published: December 2024

The utilization of sago starch as a raw material for edible films is still under development.
The properties of films produced from sago starch are not yet optimal, necessitating
research to enhance their quality. The use of a composite material consisting of tuni sago
starch and gelatin is expected to improve the characteristics of these edible films. This
research aimed to determine the characteristics of edible film composites made from sago
starch and gelatin. The research employed an experimental approach with a completely
randomized design, varying the ratio of tuni sago starch to gelatin across five treatment
levels (3:0; 2.75:0.25; 2.5:0.5; 2.25:0.75; 2:1 (g/g)). The results revealed that the
composite treatments of sago starch and gelatin produced films with thickness values
ranging from 0.060 to 0.86 mm, tensile strength ranging from 0.62 to 9.76 MPa,
elongation ranging from 0.23 to 6.44%, solubility ranging from 28.96 to 59.01%, and
water vapor transmission rates ranging from 11.41 to 20.03 g/m2
.h. It was observed that
higher concentrations of gelatin in the edible films led to increased thickness, tensile
strength, elongation, solubility, and water vapor transmission rates.
Acidification alternatives for elaborating “salchichon” (Spanish dry fermented
sausage)
Authors: Soto-Aguilar A. , Soto-Simental S. , Islas-Pelcastre M. , Perez-Soto E. , Gonzalez-Tenorio R.
Published: December 2024

The acidification technique is widely used in the meat industry to increase meat product
security and quality. The most popular acidified and fermented meat product is
salchichon. The objective of this study was to determine the effect of alternatives to lactic
acid bacteria for elaborating salchichon. Three treatments were prepared to acidify the
meat product: glucono delta lactone (GDL), apple cider (SID) and a commercial starter
(BAL) as control. When the meat product reached a weight loss of 35%, physicochemical
parameters, microbial groups and sensory analyses were evaluated. Results indicated that
pH decreased most in GDL and SID resulted in greater weight loss, while GDL showed
the lowest pH value at the end of the fermentation process. There were also statistical
differences in cohesiveness and resilience. Moreover, there was no presence of Salmonella
or Listeria monocytogenes in any of the treatments. The sensory analysis indicated that the
treatment added with apple cider scored the highest for color, while both SID and BAL
were the most accepted in terms of taste. It was concluded that apple cider and glucono
delta lactone can be used for acidification during the elaboration of the salchichon, as pH
levels decline quickly, thereby reducing the processing time without affecting the quality
of the final product
Characteristics of dark chocolate produced using tengkawang (Shorea
sumatrana) fat in various substitution levels
Authors: Mursalin M. , Yernisa Y. , Oktariani P. , Achmad E.
Published: December 2024

Dark chocolate is a variant of chocolate products made by emulsifying a mixture of sugar,
vanilla, milk, and cocoa powder into cocoa butter (CB) with the addition of lecithin as an
emulsifier. Substitution of CB with other fats such as fat from tengkawang (Shorea
sumatrana) seeds (TF) is possible in making dark chocolate because both have almost the
same characteristics. This study aimed to determine the effect of TF as a CB substituent
on the physical and organoleptic properties of dark chocolate and to determine the optimal
percentage of substitution to produce dark chocolate with characteristics that are not
different from those without substitution. The study was arranged in a completely
randomized design with six levels of CB/TF ratio (P) treatment which was repeated 3
times. The six treatment levels included were: P0 = 100/0, P1 = 90/10, P2 = 80/20, P3 =
70/30, P4 = 60/40 and P5 = 50/50. The substitution of CB with TF significantly affected
the physical and organoleptic properties of dark chocolate, especially on the melting point,
fat blooming and its acceptance level on odor and taste. Based on the level of panelist
acceptance, the percentage limit for CB substitution with TF should not be more than 20%
to produce a chocolate taste with high preference.
Manifestação do Pensamento Crítico por estudantes do ensino médio de química por meio da metodologia de Estudo de Caso
Authors: Silva Mateus Oliveira , Suart Rita de Cássia
Published: December 2024

Este artigo explora a utilização da metodologia de Estudo de Caso para promoção do Pensamento Crítico em estudantes de química, abordando situações próximas ao cotidiano dos alunos. A química, constantemente apresentada de maneira distante à realidade dos estudantes, é trabalhada nessa pesquisa a partir da produção de cachaça, e envolve questionamentos que incentivam na consideração de diferentes aspectos para tomadas de decisões que considerem o bem-estar social e o cuidado ambiental. Esta pesquisa qualitativa foi desenvolvida em uma escola pública com alunos do terceiro ano do ensino médio na disciplina de química. Apesar de uma resistência inicial dos estudantes às argumentações e questionários, ao longo do processo os alunos se tornaram mais participativos e motivados. Os resultados indicam que o Estudo de Caso contribuiu para o desenvolvimento de habilidades relacionadas ao Pensamento Crítico.
Orthogonal Stability of Additive Functional Equation in Fuzzy β-Normed Spaces
Authors: Nila M. , Vijayalakshmi A. , Balamurugan M. , Gayathri S. , Thangapandi K. , Punniyamoorthy K. , Prabaharan N.
Published: December 2024

The primary objective of this study is to present a novel form of generalised additive functional equation \(\phi\Big(\sum_{j=1}^{l}j v_{j}\Big)=\sum_{j=1}^{l}j \phi(v_{j}),\) where \(l\geq 2\) with each \(v_{i}\bot v_{j};~ i \neq j =1,2,\cdots,l,\) and derive its solution. Mainly, we examine the Hyers-Ulam-Rassias orthogonal stability of this equation by utilizing two different approaches.
Central placenta previa – a relevant medical-social Problem of modern society
Authors: A.A.Qasımova
Published: December 2024

Placenta previa, from the Latin "prae" meaning "in front" and "via" meaning "on the way," refers to an abnormal placement of the pla­centa. Historically, the term "placenta previa" was first described in the 16th century by Hippocrates, who also identified various forms of placental loca­tion . In 1685, French physician Paul Portal docu­mented a clinical case of placenta previa. It is widely recognized that placenta previa is defined as the complete or partial covering of the cervical os by the placenta .