bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct Oral Anticoagulants for the Treatment of Cerebral Venous Thrombosis
Authors: Lurkin Antoine , Derex Laurent , Fambrini Alexandra , Bertoletti Laurent , Epinat Magali , Mismetti Patrick , Dargaud Yesim
Published: September 2019

Background: Cerebral venous thrombosis (CVT) is an uncommon neurological condition usually treated with heparin followed by oral vitamin K antagonists (VKAs). In patients with venous thromboembolism (VTE), compared to VKAs, direct oral anticoagulants (DOACs) offer several advantages. However, there is little data concerning their use in managing CVT. Aims: This retrospective observational study pursued 2 objectives: (1) to investigate clinical characteristics of CVT patients treated with heparin + DOACs vs. heparin + standard treatment; (2) to compare clinical outcomes. Methods: Consecutive CVT patients recruited from January 2016 to March 2018 in 2 French university hospitals (Lyon, Saint-Etienne), and treated with DOACs or VKAs were identified. Radiological evolution, VTE, hemorrhagic events, and antithrombotic medication were recorded. Functional outcome was assessed by the modified Rankin scale score and venous recanalization was assessed by magnetic resonance imaging. Results: Overall, 41 patients were included: 25 (61%) received VKAs and 16 (39%) DOACs. We identified no clinical or radiological features explaining the physicians’ preference for a specific anticoagulation treatment, and age, initial clinical presentation, radiological severity, and individual risk factors thus unlikely guided the choice of anticoagulant. No DOAC patient exhibited clinical or radiological thrombosis aggravation, and the thrombosis completely vanished in 6 (40%). Two of the VKA-treated patients (28.6%) demonstrated complete venous recanalization, whereas 3 others experienced clinical or radiological aggravation versus baseline. There was no major bleeding leading to hospitalization in both groups. Conclusion: The collected data on DOAC efficacy and safety in CVT management appear encouraging, yet needs to be confirmed by larger prospective randomized clinical trials.
General Anesthesia Management for Adult Mucopolysaccharidosis Patients Undergoing Major Spine Surgery
Authors: Tsuchiya Masahiko , Terai Hidetomi , Mizutani Koh , Funai Yusuke , Tanaka Katsuaki , Yamada Tokuhiro , Mori Takashi , Nishikawa Kiyonobu
Published: September 2019

Objective: Mucopolysaccharidosis (MPS) are a group of rare systemic lysosomal storage diseases associated with severe airway obstruction and cardiac disease, making anesthesia management difficult. Contemporary treatment extends the lifespan of affected individuals, increasing the need for major surgery in adulthood. Clinical Presentation and Intervention: We provided general anesthesia for 6 adult MPS patients undergoing spine surgery. The airway was assessed as difficult in all, with 2 receiving awake fiberoptic intubation and 1 successfully undergoing video-laryngoscopy, while 3 video-laryngoscopy procedures failed and required conversion to fiberoptic intubation. One patient developed ventricular fibrillation. Conclusion: Adult MPS patients have substantial anesthesia risk.
A performatização da política institucional
Authors: Chiari Gabriela Serpa , Mendonça Maria Beatriz Braga
Published: September 2019

O artigo toma como ponto de partida os estudos em processo de desenvolvimento em investigações acadêmicas do Programa de Pós-Graduação em Artes/Artes da Cena da Universidade Federal de Minas Gerais sobre a corporeidade no Teatro do Oprimido. Apresenta também, por meio da metodologia de relato de experiência, uma prática de resistência estética de realização do Teatro do Oprimido, mais especificamente a técnica do Teatro Legislativo, no âmbito da Gabinetona, por meio do grupo AzDiferentonas!, na cidade de Belo Horizonte, Minas Gerais.
O último estúdio de Stanislávski
Authors: Moschkovich Diego
Published: September 2019

Este artigo traça uma abordagem histórica acerca da criação do Estúdio de Ópera e Arte Dramática, também conhecido como o último estúdio de Stanislávski, que existiu de 1935 a 1938, ano de sua morte. A pesquisa foi realizada como preparação para o trabalho sobre os procedimentos pedagógicos dos últimos anos de Stanislávski, realizado nos arquivos do museu do Teatro de Arte de Moscou entre novembro de 2017 e fevereiro de 2018. O artigo apresenta, assim, uma introdução, em que contextualiza o Estúdio de Ópera e Arte Dramática; em seguida, esboça alguns de seus antecedentes históricos, como o projeto de uma “Academia da Arte Teatral” proposta por Maksim Górki e desenvolvida por Stanislávski. Na sequência, busca algumas informações de um outro personagem-chave na criação do estúdio, a diretora e pedagoga Zinaída Sokolova, irmã de Stanislávski. Por fim, mostra o processo seletivo e a cerimônia de abertura do estúdio, em novembro de 1938.
Jacó Guinsburg
Authors: Rinaldi Miriam
Published: September 2019

O nome de Jacó Guinsburg há muito pertence à história do mercado editorial brasileiro, o que se justifica pela extensa e insubstituível produção da Editora Perspectiva, mas, sobretudo, à história das artes da cena, devido à sua incontável colaboração ao pensamento estético e crítico, da teoria e da prática teatral, no Brasil. A envergadura de sua atuação é tão ampla, que passaram por ele as mais importantes figuras do cenário cultural entre artistas e pesquisadores espalhados nas principais entidades, faculdades e palcos de nosso tempo. Ao longo dos 27 anos em que lecionou na Universidade de São Paulo e mais outros tantos em que, mesmo depois de aposentado, se dedicou à orientação de pesquisa, guiou pessoas como: José Possi Neto, Cacá Rosset, Luiz Roberto Galizia, Sílvia Fernandes, Silvana Garcia, Ingrid Dormien Koudela, João Roberto de Faria, Rosangela Patriota, Sandra Chacra, Beth Lopes, Gabriel Vilela, Antônio Araújo, Cibele Forjaz, Maria Thais, Sérgio de Carvalho, William Pereira, Lúcia Romano, Sérgio Salvia Coelho, Márcio Marciano, Matteo Bonfitto, Johana Albuquerque, Abílio Tavares, Bosco Brasil, Sônia Azevedo, Isa Kopelman, Armando Sérgio Silva, Renato Cohen… só para citar alguns. O professor Jacó Guinsburg é uma referência ímpar: um farol.
Combinatorial Treatment Using Umbilical Cord Perivascular Cells and Aβ Clearance Rescues Vascular Function Following Transient Hypertension in a Rat Model of Alzheimer Disease
Authors: Bazzigaluppi Paolo , Beckett Tina L. , Koletar Margaret M. , Hill Mary E. , Lai Aaron , Trivedi Arunachala , Thomason Lynsie , Dorr Adrienne , Gallagher Denis , Librach Clifford L. , Joo Illsung L. , McLaurin JoAnne , Stefanovic Bojana
Published: September 2019

Transient hypertension is a risk factor for Alzheimer disease (AD), but the effects of this interaction on brain vasculature are understudied. Addressing vascular pathology is a promising avenue to potentiate the efficacy of treatments for AD. We used arterial spin labeling magnetic resonance imaging to longitudinally assess brain vascular function and immunohistopathology to examine cerebrovascular remodeling and amyloid load. Hypertension was induced for 1 month by administration of
l
-N
G
-nitroarginine-methyl-ester in TgF344-AD rats at the prodromal stage. Following hypertension, nontransgenic rats showed transient cerebrovascular changes, whereas TgF344-AD animals exhibited sustained alterations in cerebrovascular function. Human umbilical cord perivascular cells in combination with scyllo-inositol, an inhibitor of Aβ oligomerization, resulted in normalization of hippocampal vascular function and remodeling, in contrast to either treatment alone. Prodromal stage hypertension exacerbates latter AD pathology, and the combination of human umbilical cord perivascular cells with amyloid clearance promotes cerebrovascular functional recovery.
Cortical Tracking of Surprisal during Continuous Speech Comprehension
Authors: Weissbart Hugo , Kandylaki Katerina D. , Reichenbach Tobias
Published: September 2019

Speech comprehension requires rapid online processing of a continuous acoustic signal to extract structure and meaning. Previous studies on sentence comprehension have found neural correlates of the predictability of a word given its context, as well as of the precision of such a prediction. However, they have focused on single sentences and on particular words in those sentences. Moreover, they compared neural responses to words with low and high predictability, as well as with low and high precision. However, in speech comprehension, a listener hears many successive words whose predictability and precision vary over a large range. Here, we show that cortical activity in different frequency bands tracks word surprisal in continuous natural speech and that this tracking is modulated by precision. We obtain these results through quantifying surprisal and precision from naturalistic speech using a deep neural network and through relating these speech features to EEG responses of human volunteers acquired during auditory story comprehension. We find significant cortical tracking of surprisal at low frequencies, including the delta band as well as in the higher frequency beta and gamma bands, and observe that the tracking is modulated by the precision. Our results pave the way to further investigate the neurobiology of natural speech comprehension.
Disease and Disability Metaphors in Gospel Worlds
Authors: Lawrence Louise J.
Published: September 2019

The use of leprosy and blindness metaphors in the Gospels tends to stigmatize individuals as other. Untouchability was associated with social death and sight with the navigation of both material and moral terrain. Though the majority of disease and disability metaphors in the Gospels fall within this category, there are some exceptions that subvert the normative (abled) perspective. These exceptions provide promising spaces for disability advocates to challenge ableist links between disease, disability, and malevolence, and to imagine counter-narratives in which disease and disability represent more positive themes and identities.
Reflecting on Others Before Reflecting on Self: Using Video Evidence to Guide Teacher Candidates’ Reflective Practices
Authors: Nagro Sarah A.
Published: September 2019

A convergent parallel mixed methods study investigated the potential of one teacher preparation approach for promoting candidate reflection. Thirteen candidates participated in clinical field experiences and four corresponding seminar classes with guided video analysis activities. Candidates were systematically guided through focusing on others before focusing on self and explicitly learned about a reflection continuum using an instructional framework to build prerequisite skills and ultimately improve reflective abilities. Results of paired-sample t tests indicated candidates demonstrated significantly higher reflective ability scores over time as measured by a reflection checklist. Qualitative analysis of structured interviews revealed candidates felt activities were (a) a systematic approach to authentic growth, (b) a challenging approach to necessary self-confrontation, and (c) allowed for connections between self and other. Methodological triangulation was used to validate the findings. Implications for teacher preparation research and practice are discussed.
Approximation and Scaffolding in Modern Band
Authors: Burstein Scott , Powell Bryan
Published: September 2019

Many K–12 teachers face hurdles when it comes to running a Modern Band, including the pedagogical challenges of facilitating large scale ensembles with unfamiliar repertoire and instruments. Approximation and scaffolding are two important tools teachers can use to help learners thrive in this environment. This article uses music examples to demonstrate how to approximate popular songs in a variety of ways, providing accommodations and adaptations for students of all skill levels to give all students an opportunity to learn. This article outlines how scaffolding in the Modern Band classroom allows for whole-class instruction while keeping advanced students motivated without alienating beginning students.
Effects of a Contextualized Instructional Package on the Mathematics Performance of Secondary Students with EBD
Authors: Mulcahy Candace A. , Krezmien Michael P.
Published: September 2019

This article describes a single-subject study of the effects of a contextualized instructional package on the area and perimeter performance of middle school students with emotional and behavioral disorders (EBD). The instructional package included area and perimeter problem-solving activities embedded in contextualized, or real-life, scenarios; use of manipulative techniques to reinforce concepts; and a self-monitoring component, a critical behavior management component to instructional interventions for students with EBD. Results indicated that the instructional package was effective for improving area and perimeter performance among the participants; transfer and maintenance results were mixed.
Contextualising Numismatic with Religion: Focus on Medieval Northeast India
Authors: Dutta Debajit
Published: September 2019

Coins are utility object mostly produced by the state for the use of day-do-day transactions, long-distance trade and sometimes as gifts. Hence, numismatic has mainly been used for the study of economic, political and administrative histories. But numismatic can also be used for the reconstruction of the material culture of our glorious past. By a minute study of our ancient and medieval coinage, we can get an impression about contemporary religious and cultural sensibilities of various ethnic societies. By examining the religious epithets and figures of gods and goddesses and other non-anthropogenic signs present on the coins, one can judge the religious affiliation of the state or the king. This article will address the issue of religious symbolism on medieval Northeast Indian dynastic coins like those of Tripura, Koch Behar and Ahom kingdoms and will try to ventilate how these kingdoms used coins to advocate their religio-cultural affinity as well as to maintain their sovereign stature for quite a long period in their respective domains.
Medieval (Islamic) Cities in India (1206–1764): An Environmental Review and its Contemporary Relevance
Authors: Sharma Anjali , Kumar Manoj , Singh M. P. , Mazhari H. K.
Published: September 2019

This article examines the medieval (Islamic) cities in India from an environmental and technological perspective. The main objectives of this article are (a) to identify and evaluate characteristic features of the cities that were closely linked with the natural environment, (b) to examine the environmental conservation measures, sustainable practices and eco-friendly technologies adopted in these cities, (c) to assess the environmental impact of these cities and (d) to explore those eco-friendly measures and technologies that are relevant even at present. This is a first of its kind review of the Islamic cities in India that flourished from the thirteenth to eighteenth century. Some of the important findings are the following: (a) water had a dominant role in the establishment of these cities, (b) gardens, canals, water-harvesting structures and sanitation were important characteristics of these cities that were profoundly integrated with the natural environment, (c) despite numerous environmental conservation measures adopted, several of these cities declined or were abandoned ironically due to environmental factors and (4) in response to natural environment, some exemplary eco-friendly technologies were introduced, particularly the karez technology for water-supply, which is worth considering to make contemporary Indian cities ecologically sustainable.
Impact of Savoring Ability on the Relationship Between Older Adults’ Activity Engagement and Well-Being
Authors: Smith Jennifer L. , Bihary Joseph G. , O’Connor Dugan , Basic Ajla , O’Brien Catherine J.
Published: September 2019

The relationship between activity engagement and well-being can vary based on individual characteristics, and it is important to identify moderating factors to support the development and implementation of aging services. The current study examined whether the relationship between activity engagement and well-being depends on older adults’ savoring ability, that is, the ability to attend to positive experiences and to engage in emotion regulation strategies to enhance positive feelings during those experiences. A total of 5,128 older adults ( Mage = 83.86 years) completed measures of activity engagement, savoring, and well-being (i.e., life satisfaction, depression, loneliness, purpose, and health). Multilevel modeling analyses revealed that activity engagement and savoring independently predicted better functioning across all well-being measures. However, savoring moderated the relationship between activity engagement and four well-being measures (life satisfaction, depression, loneliness, and purpose). Findings suggest that older adults with low activity engagement may particularly benefit from savoring-skills training to enhance their psychological well-being.
Pyrolysis modeling, sensitivity analysis, and optimization techniques for combustible materials: A review
Authors: Nyazika Tatenda , Jimenez Maude , Samyn Fabienne , Bourbigot Serge
Published: September 2019

Over the past years, pyrolysis models have moved from thermal models to comprehensive models with great flexibility including multi-step decomposition reactions. However, the downside is the need for a complete set of input data such as the material properties and the parameters related to the decomposition kinetics. Some of the parameters are not directly measurable or are difficult to determine and they carry a certain degree of uncertainty at high temperatures especially for materials that can melt, shrink, or swell. One can obtain input parameters by searching through the literature; however, certain materials may have the same nomenclature but the material properties may vary depending on the manufacturer, thereby inducing uncertainties in the model. Modelers have resorted to the use of optimization techniques such as gradient-based and direct search methods to estimate input parameters from experimental bench-scale data. As an integral part of the model, a sensitivity study allows to identify the role of each input parameter on the outputs. This work presents an overview of pyrolysis modeling, sensitivity analysis, and optimization techniques used to predict the fire behavior of combustible solids when exposed to an external heat flux.
Periodic-type auto-regressive moving average modeling with covariates for time-series incidence data via changepoint detection
Authors: Kalligeris Emmanouil-Nektarios , Karagrigoriou Alex , Parpoula Christina
Published: September 2019

When it comes to incidence data, most of the work on this field focuses on the modeling of nonextreme periods. Several attempts have been made and a variety of techniques are available to achieve so. In this work, in order to model not only the nonextreme periods but also capture the behavior of the whole time-series, we make use of a dataset on influenza-like illness rate for Greece, for the period 2014–2016. The identification of extreme periods is made possible via changepoint detection analysis and model selection techniques are developed in order to identify the optimal periodic-type auto-regressive moving average model with covariates that best describes the pattern of the time-series. In addition, in the context of incidence data modeling, an advanced algorithm was developed in order to improve the accuracy of the selected model. The derived results are satisfactory since the changepoint method seems to identify correctly the extreme periods, and the selected model: (1) estimates accurately the influenza-like illness syndrome morbidity burden in the case of Greece, and (2) captures satisfactorily enough the behavior of the whole time-series.
Methods to control the empirical type I error rate in average bioequivalence tests for highly variable drugs
Authors: Deng Yuhao , Zhou Xiao-Hua
Published: September 2019

Average bioequivalence tests are used in clinical trials to determine whether a generic drug has the same effect as an original drug in the population. For highly variable drugs whose intra-subject variances of direct drug effects are high, extra criteria are needed in bioequivalence studies. Currently used average bioequivalence tests for highly variable drugs recommended by the European Medicines Agency and the US Food and Drug Administration use sample estimators in the null hypotheses of interest. They cannot control the empirical type I error rate, so the consumer's risk is higher than the predetermined level. In this paper, we propose two new statistically sound methods that can control the empirical type I error rate without involving any sample estimators in the null hypotheses. In the proposed methods, we consider the average level of direct drug effects and the intra-subject variance of the direct drug effects. The first proposed method tests the latter parameter first to determine whether a product should be regarded as a highly variable drug, and then tests the former using corresponding bioequivalence limits. The second proposed method tests these two parameters simultaneously to capture the bioequivalence region. Extensive simulations are done to compare these methods. The simulation results show that the proposed methods have good performance on controlling the empirical type I error rate. The proposed methods are useful for pharmaceutical manufacturers and regulators.
The Effects of Email Performance-Based Feedback Delivered to Teaching Teams: A Systematic Replication
Authors: Barton Erin E. , Velez Marina , Pokorski Elizabeth A. , Domingo Maddisen
Published: September 2019

A multiple-baseline across behaviors design was utilized to examine the relation between performance-based feedback (PF) and the frequency of teaching teams’ use of target behaviors during observation sessions with six teachers in three inclusive preschool classrooms. Teachers increased their use of target behaviors when feedback was provided and maintained their use over time when feedback was withdrawn; however, there was considerable variability across teachers. Furthermore, teachers did not increase their use of target behaviors during covert observations—when they did not know they were being observed. The current study replicates and extends the research in this area by examining the provision of PF to teaching teams and with complex behaviors (e.g., play expansions, promoting social interactions).
Brexanolone (Zulresso): Finally, an FDA-Approved Treatment for Postpartum Depression
Authors: Powell Jason G , Garland Scott , Preston Kayla , Piszczatoski Chris
Published: September 2019

Objective: To review the safety and efficacy of brexanolone for the treatment of moderate to severe postpartum depression (PPD). Data Sources: A literature search through PubMed was conducted (January 2012 to July 2019) using the keyword brexanolone for clinical trials published in the English language. Study Selection and Data Extraction: Articles were selected if they were related to the Food and Drug Administration (FDA) approval of brexanolone or provided novel clinical information regarding this drug entity. Data Synthesis: The findings of the review show that brexanolone administered via IV infusion is both an effective and a fairly safe option for the treatment of PPD. Relevance to Patient Care and Clinical Practice: There are several antidepressants currently used to treat PPD; however, this is the first with FDA approval for this indication. The rapid onset of action of brexanolone may offer a quicker relief of these symptoms and may possibly lead to improved quality of life for both the mother and the child. Conclusion and Relevance: The recent FDA approval of brexanolone may offer an effective treatment of moderate to severe PPD and has been shown to rapidly decrease depression symptoms.
Republished: Prevention of Nosocomial Catheter-Associated Urinary Tract Infections Through Computerized Feedback to Physicians and a Nurse-Directed Protocol
Authors: Topal Jeffrey , Conklin Sandra , Camp Karen , Morris Victor , Balcezak Thomas , Herbert Peter
Published: September 2019

Catheter-associated urinary tract infections (CAUTIs) represent the most common nosocomial infection. The authors’ baseline rate of CAUTI for general medical service was elevated at 36 per 1000 catheter-days. The medical literature has consistently linked inappropriate catheter use with the development of CAUTI. The baseline data also revealed a high rate of inappropriate use of indwelling urinary catheters. Using the dual modalities of technology through prompts in the computerized order/entry system and handheld bladder scanners, as well as in combination with staff education and nurse empowerment, the authors were successful in reducing the use and duration of urinary catheters as well as the incidence of CAUTI. In subsequent data collection cycles over the following 2 years, 81% reduction in device use and a 73% reduction in the clinical end point of nosocomial CAUTI (36/1000 catheter-days to 11/1000 catheter-days; P < .001) was demonstrated.
Republished: Physician Assistant and Nurse Practitioner Utilization in Academic Medical Centers
Authors: Moote Marc , Krsek Cathleen , Kleinpell Ruth , Todd Barbara
Published: September 2019

The purpose of this study was to collect information on the utilization of physician assistants (PAs) and nurse practitioners (NPs) in academic health centers. Data were gathered from a national sample of University HealthSystem Consortium member academic medical centers (AMCs). PAs and NPs have been integrated into most services of respondent AMCs, where they are positively rated for the value they bring to these organizations. The primary reason cited by most AMCs for employing PAs and NPs was Accreditation Council for Graduate Medical Education resident duty hour restrictions (26.9%). Secondary reasons for employing PAs and NPs include increasing patient throughput (88%), increasing patient access (77%), improving patient safety/quality (77%), reducing length of stay (73%), and improving continuity of care (73%). However, 69% of AMCs report they have not successfully documented the financial impact of PA/NP practice or outcomes associated with individual PA or NP care.
Disseminated lymphoblastic lymphoma revealed by an isolated third cranial nerve palsy
Authors: Ben Salah Raida , Kammoun Sonda , Frikha Faten , Bouattour Yosra , Chabchoub Imen , Feki Jamel , Bahloul Zouhir
Published: September 2019

Dysfunction of the third cranial nerve can be provoked by a number of different conditions. An isolated cranial neuropathy as a first clinical sign of a non-Hodgkin lymphoma is very infrequent. We represent here an atypical case of lymphoblastic lymphoma revealed by an isolated third cranial nerve palsy. The patient was managed by alternating cycles of cyclophosphamide, vincristine, and prednisone. She made a full recovery with a complete resolution of the symptomatology.
Histological Transformation to Small Cell Carcinoma of an Adenosquamous Carcinoma of the Lung With Epidermal Growth Factor Receptor Mutation in Exons 20 and 21 After Treatment With Erlotinib: Case Report
Authors: Fernández-Trujillo Liliana , Tapia Laura , Vallejo Marcela , Aguirre Marisol , Lores Juliana , Sua Luz F
Published: September 2019

Lung carcinoma currently represents 1 of the leading causes of death from cancer worldwide and regionally. The molecular identification of sensitive mutations of targeted treatment have changed the strategies of pharmacologic management in non-small cell lung carcinoma. However, mechanisms of resistance have been described, among them the change of histological type to small cell carcinoma. We present the case of a 46-year-old male patient, non-smoker, with a clinical history of a mass in the upper lobe of the right lung and an initial histological diagnosis of adenosquamous carcinoma of the lung, with the presence of mutations for epidermal growth factor receptor (EGFR) in exons 20 (S768I) and 21 (L858R). He received treatment with tyrosine kinase inhibitor (Erlotinib) with good clinical and radiological response. However, 1 year after the start of the medication, he consulted for a progressive onset of constitutional symptoms and respiratory symptoms, with radiographic worsening and new biopsy with a diagnosis of adenosquamous carcinoma with the adenocarcinoma component transformed to small cell carcinoma, with persistence of EGFR mutation. We describe the clinical, radiological, and laboratory characteristics as well as the outcome of this case. To conclude, among the mechanisms of resistance described to the treatment with tyrosine kinase inhibitors in patients with carcinomas with mutated EGFR, the transformation to small cell carcinoma besides being infrequent is particular, requiring a different diagnostic and therapeutic approach.
‘We’re not like that’: Crusader and Maverick Occupational Identity Resistance
Authors: Cohen Rachel Lara
Published: September 2019

This article explores the occupational identities of hairdressers and vehicle mechanics working in small and micro firms. Using qualitative interview data from two UK cities, it examines the ways that workers expounded, reflected on and discursively reframed public perceptions of their occupation. A novel distinction between two types of identity resistance is proposed. ‘Crusaders’ are workers who perform collective occupational resistance by rejecting characterisations as inappropriate for the occupation at large, whereas ‘mavericks’ accept that popular characterisations apply to other workers but differentiate themselves. The analysis identifies differences in occupational identity resistance strategies (crusader or maverick) when workers interact with two different publics: customers and trainees.
Using conjoint analysis to understand preference for online survey layout
Authors: King Craig V , Labas Romain , Renaudin Christian
Published: September 2019

This study seeks to determine what participants prefer when taking online surveys with regard to conjoint design (number of concepts per screen) and format for grid questions. Respondents were mixed on their preference for two versus three concepts per screen. However, importance scores for incentive amount and type reversed when taking a conjoint exercise with two concepts per screen versus three concepts per screen. Participants seemed to focus more on incentives when presented with three concepts per screen than when presented with two concepts per screen. This finding was not expected and implications are discussed. In addition, the use of radio buttons versus drop-down menus in grid style questions was also explored. Respondents preferred radio buttons, and the means (repeated measures) were higher for responses for radio buttons than drop-down menus.
Candy-Plug Generation II for False Lumen Occlusion in Chronic Aortic Dissection: Feasibility and Early Results
Authors: Eleshra Ahmed , Kölbel Tilo , Tsilimparis Nikolaos , Panuccio Giuseppe , Scheerbaum Martin , Debus E. Sebastian , Mogensen John , Rohlffs Fiona
Published: September 2019

Purpose: To present the early results of false lumen (FL) occlusion in chronic aortic dissection using the Candy-Plug generation II (CP II), which has a self-closing fabric channel that obviates the need for separate occlusion of its center. Materials and Methods: Fourteen consecutive patients (mean age 60±11 years; 10 men) with persistent FL backflow and aneurysm formation at the thoracic segment in chronic aortic dissection underwent thoracic endovascular aortic repair (TEVAR) with FL occlusion using the refined CP II. Primary endpoints were technical success (successful deployment) and clinical success (no FL backflow at the CP II level). Secondary endpoints included 30-day mortality and morbidity and aortic remodeling during follow-up. Results: Technical success was 100%. One patient required additional intraprocedural FL embolization at the CP II level due to persistent FL backflow on final angiography (clinical success 93%), though there was no flow through the CP II center. There were no intraprocedural complications. Immediate complete FL occlusion was achieved in 12 patients; the other 2 required reintervention. One had contrast enhancement in the distal FL proximal to the CP II and was treated with coil embolization. The other patient had persistent type I endoleak at the level of the left subclavian artery (LSA) and underwent left carotid–LSA bypass and proximal stent-graft extension. One patient died due to retrograde type A aortic dissection that was not related to CP II placement. Over a mean 8-month follow-up (range 3–12), 9 patients had computed tomography angiography; 8 patients had evidence of aortic remodeling, while 1 aneurysm sac was stable. Conclusion: The CP II reduces the number of procedural steps and offers good seal, with minimal morbidity and mortality and a high rate of aortic remodeling.
A Single-Center Experience of the Optimal Initial Immunosuppressive Strategy for Preventing Early Acute Cellular Rejection in Orthotopic Heart Transplantation Associated With Renal Dysfunction
Authors: Mundisugih Juan , Fernando Himavan , Bergin Peter , Hare James , Kaye David , Leet Angeline , McGiffin David , Taylor Andrew J.
Published: September 2019

Background:

Renal dysfunction is a common complication following heart transplantation that may be worsened by the early initiation of calcineurin inhibitors. Antithymocyte globulin (ATG) or basiliximab has been used to delay or avoid calcineurin inhibitors. The most effective strategy for preventing early acute cellular rejection in this context is uncertain.

Methods:

We retrospectively reviewed all heart transplant cases between January 2012 and June 2017. The standard therapy consisted of mycophenolate mofetil, prednisolone, and tacrolimus. In patients at high risk of post-transplant renal dysfunction, an early calcineurin inhibitor-free regimen with basiliximab and/or ATG was used. Patients were assigned to cohorts based on the initial immunosuppressive strategy. The primary end point was the freedom rate of acute cellular rejection within 4 weeks post-transplant.

Results:

Of 93 cases, 21 patients received standard therapy, 64 patients received an initial calcineurin inhibitor-free regimen with basiliximab, and 8 patients received ATG and basiliximab. Freedom from acute rejection was greater in the ATG plus basiliximab group (all rejection free), compared to 40 (63%) of 64 patients treated with basiliximab and 10 (48%) of 21 patients treated with standard therapy ( P < .05, log rank test). In patients treated with basiliximab, early administration (<24 hours) was associated with a higher freedom from acute rejection compared to ≥24 hours, (72% vs 29%, P < .05).

Conclusions:

The combination of ATG and basiliximab was more effective in preventing acute cellular rejection. In those patients treated with basiliximab, rejection rates were no worse than standard therapy; however, it was only effective when administered within 24 hours.
The interplay between control processes and feature relevance: Evidence from dual-task methodology
Authors: Montefinese Maria , Hallam Glyn , Thompson Hannah Elizabeth , Jefferies Elizabeth
Published: September 2019

Neuropsychological studies suggest a distinction between (a) semantic knowledge and (b) control processes that shape the retrieval of conceptual information to suit the task or context. These aspects of semantic cognition are specifically impaired in patients with semantic dementia and semantic aphasia, respectively. However, interactions between the structure of knowledge and control processes that are expected during semantic retrieval have not been fully characterised. In particular, domain-general executive resources may not have equal relevance for the capacity to promote weak yet task relevant features (i.e., “controlled retrieval) and to ignore or suppress distracting information (i.e., “selection”). Here, using a feature selection task, we tested the contribution of featural relevance to semantic performance in healthy participants under conditions of divided attention. Healthy participants showed greater dual-task disruption as the relevance value of the distractor feature linearly increased, supporting the emerging view that semantic relevance is one of the organising principles of the structure of semantic representation. Moreover, word frequency, and inter-correlational strength affected overall performance, but they did not show an interaction with dual-task conditions. These results suggest that domain-general control processes, disrupted by divided attention, are more important to the capacity to efficiently avoid distracting information during semantic decision-making than to the promotion of weak target features. The present study therefore provides novel information about the nature of the interaction between structured conceptual knowledge and control processes that support the retrieval of appropriate information and relates these results to a new theoretical framework, termed controlled semantic cognition.
Staging Repentance: A Discourse Analysis of Mediated Confession in Xi Jinping's First Five-Year Term
Authors: Liu Yuanyuan
Published: September 2019

Since Xi Jinping took office as General Secretary of the Chinese Communist Party, he has been tightening ideological control across many fronts. This article investigates how the framing of televised confessions facilitates Xi's rule. Originating from the intra-Party disciplinary technique of self-criticism, the recent resurgence of mediated confessions reflects Xi's pursued strategy in tackling social and political challenges. Applying critical discourse analysis to the case of the disappeared Swedish bookseller Gui Minhai, this paper shows the way in which the framing of Gui's televised confession follows Xi's so-called rule of law agenda and selectively appeals to traditional Chinese family values. The paper argues that the propaganda value of the televised confession from a little-known, non-Party confessant lies in its banality, which blends into the Party's everyday narration. The resurgence of confessions might suggest a regression towards Maoist-style campaigns, but more audience-oriented research is needed to address this issue fully.
Diplomatic Control, Foreign Policy, and Change under Xi Jinping: A Field-Theoretic Account
Authors: Loh Dylan M. H.
Published: September 2019

This article outlines how Xi Jinping has exercised control over diplomatic actors, particularly China's Ministry of Foreign Affairs, and draws out the effects of this control for the ministry and for Chinese foreign policy. Leveraging Bourdieu's (1984) concept of “field,” I demonstrate how Xi has – through processes of socialisation, restriction, and displays of fealty – bred local diplomatic field incentives in which actors exhibit more loyal, assertive, and disciplined behaviour. Next, I introduce the idea of “transversal disruption” – the potential of local fields to disrupt and introduce change on and in overlapping fields, and vice versa. Practice theorists have relatively little to say about inter-field effects, and this article seeks to fill this gap by showing how field rules in the transnational diplomatic space can change when fields meet. I illustrate the above through three cases of field encounters: the multilateral Track II diplomacy field; the transnational fields of the Association of Southeast Asian Nations (ASEAN); and, the China–Malaysia bilateral diplomatic field.
Screening for Chronic Hepatitis C Virus: Occupational Health Nurses Interpreting the Titers
Authors: Cadet Myriam Jean
Published: September 2019

Chronic hepatitis C virus (HCV) can lead to serious health consequences or even death if titers are misinterpreted during screening. Occupational health nurses (OHNs) need to understand HCV titers to prevent adverse health outcomes among workers.
Association Between Genetic Polymorphisms in Metaloproteinases of the Matrix and Delayed Tooth Emergence: A Cross-sectional Study
Authors: Evangelista Silvane Silva , Arid Juliana , Vasconcelos Katia Regina Felizardo , Cruz Giuseppe Valduga , Dutra André Luiz Tannus , da Silva Lea Assed Bezerra , da Silva Raquel Assed Bezerra , Nelson-Filho Paulo , Vieira Alexandre Rezende , de Queiroz Alexandra Mussolino , Küchler Erika Calvano
Published: September 2019

Background and Aims:

Animal models have been demonstrating that MMPs have an important function in the tooth eruption process. The aim of this study was to evaluate the association between genetic polymorphisms in MMP8 and MMP13 and delayed tooth eruption of permanent teeth.

Materials and Methods:

This cross-sectional study selected 216 children, 9- to 12-year-old, from public schools at Manaus, Amazonas, Brazil. During oral clinical examination, each permanent tooth emerged in the oral cavity was evaluated. Children were considered with delayed tooth eruption when at least one permanent tooth was delayed and were classified in 2 groups: children “with delayed tooth emergency” and “without delayed tooth emergency.” Saliva samples were collected from DNA extraction. The genetic polymorphisms rs17099443 and rs3765620 in MMP8, and rs478927 and rs2252070 in MMP13 were genotyped.

Statistical Analysis:

PLINK V1.07 ( http://pngu.mgh.harvard.edu/purcell/plink/ ) and GraphPad Prism 5.0 (San Diego, CA, USA) were used. The c2 or Fisher exact test was used to calculate genotypes and alleles distributions. To compare the mean number of delayed teeth according to genotypes, the Kruskal-Wallis test with multiple comparison Dunn test was used. The established alpha for all comparisons was .05.

Results:

The polymorphism rs17099443 in MMP8 was associated with delayed tooth eruption in the genotype distribution ( P = .05). In the allele distribution, the C allele was underrepresented in children with delayed tooth eruption ( P = .01; OR = 0.61, 95% confidence interval, 0.41–0.9).

Conclusion:

The genetic polymorphism rs17099443 in MMP8 is associated with delayed tooth eruption.
“I Was Not Told That I Still Have The Virus”: Perceptions of Utilization of Option B+ Services at a Health Center in Malawi
Authors: Mulewa Patience , Satumba Egrina , Mubisi Christopher , Kandiado Joseph , Malenga Tumaini , Nyondo-Mipando Alinane Linda
Published: September 2019

Utilization of the prevention of mother-to-child transmission of HIV (PMTCT) services remains a challenge as losses to follow-up are substantial. This study explored factors that influence adherence to maternal antiretroviral (ARV) medications among PMTCT mothers in Malawi. We conducted a descriptive qualitative study from September 2016 to May 2017 using purposive sampling among 16 PMTCT mothers and 4 key informant interviews with health-care workers. Data were audio-recorded and analyzed thematically. The factors that influence adherence to maternal ARV medications include the quality of PMTCT services and social support. Factors that impede adherence include suboptimal counseling women receive on ARV medications, cost of travel, and conflicting advice from religious institutions. Adherence to maternal ARV medications will require the use of existing social support systems in a woman’s life as a platform for delivery of the drugs while also maintaining continued and comprehensive counseling on the benefits of maternal ARV medications.
Educational Attainment and Nonwage Labor Market Returns in the United States
Authors: Schudde Lauren , Bernell Kaitlin
Published: September 2019

Although decades of research highlight the impact of schooling on earnings, less evidence exists regarding other employment outcomes. Nonwage labor market returns to education are important in the United States, where health insurance and retirement income are typically tied to employment. Using longitudinal, nationally representative data, we examine the role of educational attainment in predicting nonwage employment outcomes and control for a host of individual and institutional measures. Even after controlling for individual and institutional characteristics, results indicate that educational attainment predicts employment and markers of “good” jobs, like access to employer-provided health and dental insurances, retirement plans, and paid leave. Furthermore, by delineating between various subbaccalaureate levels of college attainment, our results illustrate the complex variation in returns to college for those who did not complete a 4-year degree.
Ambidextrous Program Management: The Case of Autonomous Mobility
Authors: Midler Christophe , Maniak Rémi , de Campigneulles Théodore
Published: September 2019

This article analyzes the management of project portfolios that encompass both exploratory and implementation projects under the denomination of ambidextrous program management. We build on the project/program and ambidexterity literature to characterize such programs. Based on an in-depth three-year study, we apply this analytical framework to an emblematic case: the Autonomous Mobility (AM) initiative of a major automotive firm. We characterize the coordination challenges of such ambidextrous program management, and propose a coordination concept to deal with them, which we term the program hub.

Our contribution to the project management field is to extend the scope of analysis to a new type of program that simultaneously coordinates both exploratory and implementation projects. We also advance the ambidexterity field by demonstrating how ambidextrous program management can orchestrate different types of ambidextrous organizational patterns within the firm. For practitioners, we illustrate the multibillion-dollar innovation initiative focused on autonomous mobility that is ongoing within the auto industry.
Prevalence of Helicobacter pylori Infection, Its Virulent Genotypes, and Epstein-Barr Virus in Peruvian Patients With Chronic Gastritis and Gastric Cancer
Authors: Castaneda Carlos A. , Castillo Miluska , Chavez Iván , Barreda Fernando , Suarez Nancy , Nieves Jais , Bernabe Luis A. , Valdivia Daniel , Ruiz Eloy , Dias-Neto Emmanuel , Landa-Baella Maria P. , Bazan Yaqueline , Rengifo Carlos A. , Montenegro Paola
Published: September 2019

PURPOSE

Helicobacter pylori (HP) and Epstein Barr virus (EBV) infections induce chronic gastritis (CG) and are accepted carcinogenics of gastric cancer (GC). Our objective for this study was to determine the prevalence of these agents and clinicopathological features of GC and CG associated with the infection.

PATIENTS AND METHODS

A single-center cohort of 375 Peruvian patients with GC and 165 control subjects with CG were analyzed. Evaluation of HP and EBV genes was performed through quantitative polymerase chain reaction.

RESULTS

Prevalence of HP was 62.9% in the whole population and 60.8% in the GC subset. The cagA gene was detected in 79.9%; vacAs1 and vacAm1 alleles in 41.6% and 60.7%, respectively; and concurrent expression of vacAs1 and vacAm1 in 30.4% of infected patients in the whole series. The prevalence of EBV was 14.1% in the whole population and was higher in GC ( P < .001). Coinfection of HP and EBV was found in 7.8% and was also higher in GC in univariate ( P < .001) and multivariate ( P = .011) analyses. Infection rates of HP and EBV were not associated with a geographic location in the whole series. Few clinicopathological features have been associated with infectious status.

CONCLUSION

Prevalence of HP infection and virulent strains are high in the Peruvian population. Infection by EBV was more frequent in patients with GC.
Ladja: Luta para dançar
Authors: Monteiro Edu
Published: September 2019

Através de duas pesquisas distintas, separadas por um hiato de oitenta anos, o artigo investiga as transformações decorrentes do processo de ocidentalização na ladja – uma dança de combate embalada pelo canto e o toque do tambor, nascida nas encruzilhadas da diáspora africana na Martinica.  Palavras-chave: Ladja. Dança de combate. Diáspora africana. Arte na Martinica.  Abstract Through two different researches, separated by a gap of eighty years, the article investigates the transformations resulting from the process of westernization in the ladja – a combat dance performed by the chant and the drumming, born at the crossroads of the African diaspora in Martinique. Keywords: Ladja. Combat dance. African diaspora. Art in Martinique.