bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluación de la contaminación microbiológica y fisicoquímica de las aguas superficiales de los Pantanos de Villa
Authors:   , Valdivia Correa Astrid Briggithe
Published: November 2022

El Refugio de Vida Silvestre Los Pantanos de Villa se localiza en la zona urbana de Lima Metropolitana (Perú). Este ecosistema, a pesar de ser un área natural protegida por el Estado, se encuentra frecuentemente impactado por el ser humano con residuos sólidos, aguas residuales, entre otros. A partir de una evaluación de la calidad de agua superficial del humedal en el 2021, se determinó su estado actual considerando tres cuerpos de agua diferentes; manantial o fuente (Las Palmeras), canal (Sangradero) y lagunas (Las Delicias y Mayor). Los resultados reflejaron condiciones favorables en cuanto al contenido de pH en un rango de 7.0 a 8.5, la conductividad en un rango de 2630 a 10,390 µS/cm debido a la naturaleza del humedal costero cercano al mar. Sin embargo, para los parámetros de demanda bioquímica de oxígeno (DBO), nitratos, aceites y grasas, y oxígeno disuelto sobrepasaron los Estándares de Calidad de Agua, categoría 4, subcategoría 1 (DS-004-2017-MINAM). Para algunos casos como el parámetro de aceites y grasas y nitratos, sobrepasaron los estándares de normas internacionales como ASEAN, CONAGUA y Criterios Ecológicos de Calidad del Agua CE-CCA-001/89. Así mismo, para obtener una calificación integral de la calidad de agua se usó la propuesta del ICA-PE de Perú para identificar el estado actual de la calidad de agua. Se obtuvo que el manantial se encuentra un estado regular y las lagunas y el canal en un estado de calidad de agua malo, lo que significaría que dichas áreas se encuentran con una fuente de contaminación constante y representa un riesgo para la salud pública y los servicios ecosistemas involucrados.
Implementación de inteligencia de negocios para mejorar la gestión de servicios de infraestructura TI para la empresa Centro SA
Authors:   , Chuquitaype Morante Jesus Armando Martin , Sotomayor Hurtado Victor Hugo
Published: November 2022

Se propone la implementación de inteligencia de negocios con el objetivo principal de mejorar, la gestión de servicios, de infraestructura TI de la empresa, Centro SA brindando una disponibilidad total de sus servicios sin interrupciones con la finalidad de garantizar la continuidad del negocio. Este estudio tuvo un enfoque cuantitativo bajo método hipotético deductivo, con tipo aplicada, teniendo un diseño pre-experimental. La información analizada es en base a los registros de solicitudes, requerimientos e incidencias de agosto y Setiembre 2021 por los servicios de SAP, Plataforma y Correo, apoyados en la técnica de recolección de datos: observación y bajo el instrumento de Ficha de observación. Los datos fueron procesados con el software SPSS para generar las tablas de estadística descriptiva cuyos resultados se presenta en la investigación. Se concluye que la inteligencia, de negocios mejora la gestión de servicios de infraestructura TI, para la empresa Centro S.A. - 2021, bajo un diseño pre-experimental como solución, lo cual se visualiza en los resultados mostrados bajo la prueba U de Mann Whitney obteniéndose diferencias favorables de puntaje entre Pre Test y Post Test en la prueba de significancia 0.000 menor que 0.05 y Z es -6,775 menor que -1,96.
Desarrollo de un aplicativo móvil para informar los beneficios sociales y remuneraciones de los colaboradores de la lavandería Delfus S.A.C, 2021
Authors:   , Barrientos Antay Erwin Kenyu , Barrientos Antay Jennie Yoselin
Published: November 2022

El objetivo del estudio fue determinar la manera de como el aplicativo móvil informará sobre los beneficios sociales y remuneraciones de los colaboradores que trabajan en la lavandería DELFUS S.A.C. Esta investigación se llegó a realizar con un enfoque cuantitativo, tipo aplicada, con diseño preexperimental y de corte longitudinal. La muestra se realizó a los 28 colaboradores que pertenecen al área operativa la empresa. Los instrumentos obtuvieron un alfa de Cronbach, para el Pre Test 0.936 y para el Post Test 0.894. Se obtuvo como significancia con un sig = 0.000, lo cual es menor al porcentaje de margen de error de 0.05. Dado que sig es menor a 0.05, se rechaza la hipótesis nula y acepta hipótesis alterna.
Efectividad comparativa del ozono periarticular sobre puntos de acupuntura intestino grueso 2, intestino grueso 3, intestino delgado 3 y triple recalentaror 2; y tratamiento convencional en artritis traumática crónica de la articulación metacarpo falángiana en equinos del Hipodromo de Monterrico
Authors:   , Simonetti Konakova Anna Catalina
Published: November 2022

El objetivo del presente estudio es determinar la acción del ozono periarticular sobre puntos de acupuntura en la articulación metacarpo falangiana que presenten artritis traumática crónica. Con este fin, se utilizaron 12 caballos pura sangre ingles del Hipódromo de Monterrico, los cuales se dividieron en dos grupos: grupo control y grupo ozono. Al grupo control, se le aplicó el tratamiento convencional de Amikacina a 0.5mg/Kg , Triamcinolona a 0.012 mg/Kg , Ácido Hialurónico a 0.02 mg/Kg y Cloruro de Amonio a 0.06 mg/Kg, una sola vez; mientras que al grupo de ozono de 18µg/ml, por tres sesiones de ozonoterapia en acupuntos intestino grueso 2, intestino grueso 3, intestino delgado 3 y triple recalentador 2. El tratamiento de ozonoterapia se realizó una vez a la semana. Para las variables cuantitativas, se realizó el análisis de varianza de medida repetida, probando la hipótesis nula de que las matrices de covarianzas observadas de las variables dependientes son iguales entre los grupos. En el caso de las variables cualitativas, se utilizó la prueba de Fisher, donde la variable de vistas radiográficas mostraba gran diferencia estadísticamente significativa (p<0.05) entre el grupo de ozono y el grupo de tratamiento convencional. A diferencia de otras tres variables cuantitativas, las cuales no mostraron diferencias estadísticamente significativas (p>0.05) entre los grupos. Los cambios confirmados de manera estadística en el grupo experimental con ozono, indicaría la eficacia del tratamiento y mostrando así, que este tipo de lesión responde a las dos terapias de manera positiva, siendo este tratamiento una nueva opción para este tipo de lesiones.
Análisis de la producción científica médica peruana sobre Covid-19 en Scopus
Authors:   , Burga Diaz Dayana Soledad , Ruiz Calle Jorge Luis
Published: November 2022

Objetivo: Determinar la tendencia, impacto y colaboración de la producción científica mundial de la medicina peruana relacionada con el COVID-19 mediante un análisis bibliométrico en la base de datos Scopus. Método: Se utilizó una estrategia de búsqueda especializada para obtener todos los manuscritos publicados en revistas indexadas en la base de datos Scopus para analizar las tendencias, impacto y colaboraciones de la producción científica mundial de la medicina peruana (2019-2021), utilizando una fórmula compleja derivada del MesH (MedLine) y Emtree (EMBASE) formando tesauros vinculados con la enfermedad del coronavirus 2019 y sus múltiples términos, usando los operadores booleanos "OR" y "AND". Se utilizó SciVal para el análisis bibliométrico de los datos obtenidos, los cuales se llevaron a Microsoft Excel para la elaboración de tablas. Resultados: Se encontraron 885 manuscritos de la base de datos de Scopus por medio de uso de fórmula compleja, que fueron publicados entre el 2019 y el 2021. El pico máximo de publicaciones sucedió en el año 2021 (70%), siendo la revista que más publicó Revista Peruana de Medicina Experimental y Salud Pública, y como entidad mayormente productora de artículos científicos que conciernen al tema, el Ministerio de Salud del Perú seguido de las universidades Peruana Cayetano Heredia y la Universidad Científica del Sur. La mayoría de las publicaciones se ubicaron en el cuartil Q3 y Q1 con 275 y 216 publicaciones respectivamente en cada cuartil. Conclusiones: La producción científica médica peruana con relación al COVID-19 sigue expandiéndose académicamente y la mayoría de dichas publicaciones se hallan en los cuartiles CiteScore Q3 y Q1, con una tendencia creciente hacia el cuartil Q1. Entre las instituciones públicas y privadas destacan Minsa, UPCH, EsSalud, UCSur y UNMSM por su mayor número de publicaciones...
Control de inventarios y su relación con la rentabilidad del Grupo Isamisa S.A.C., Ate - Vitarte 2018-2020
Authors:   , Gonzales Diaz Bilma , Quispe Naveros Leyda Diana
Published: November 2022

Nuestra investigación tiene como título “Control de inventarios y su relación con la rentabilidad del GRUPO ISAMISA S.A.C., Ate – Vitarte 2018-2020”, por cuanto busca demostrar y resaltar la importancia de como el buen manejo y control de las existencias, inciden en rentabilidad de organización investigada durante periodos 2018 al 2020, aplicando un análisis de autores nacionales e internacionales, con marco teórico donde se definen las variables planteadas así como sus dimensiones para mejor entendimiento de la investigación. La metodología ha sido del tipo aplicada, del tipo descriptivo y correlacional, siendo no experimental y de corte longitudinal por tener en cuenta un estudio de varios periodos de tiempo, asimismo, la técnica utilizada es el análisis documental. Los principales resultados obtenidos en el periodo 2018-2020 son los siguientes: (i) en el año 2020 obtuvo su mayor porcentaje de rentabilidad sobre sus activos; (ii) el costo de venta tiene un valor en promedio 80% sobre total de sus ingresos; (iii) el inventario tiene un largo periodo de rotación influyendo directamente a la rentabilidad. Como conclusión se aprueba objetivo general de tesis que fue: Determinar la relación del control de inventarios con la rentabilidad del GRUPO ISAMISA S.A.C en el periodo 2018-2020.
El efecto de los factores socioeconómicos sobre el crimen: evidencia para Perú a nivel departamental, 2011-2018
Authors:   , Fernandez Rodriguez Veronica , Tafur Santillan Jorge Isaac
Published: November 2022

El objetivo de esta investigación es determinar si es posible predecir la criminalidad en el Perú a nivel departamental utilizando la información de variables socioeconómicas. Para ello se estima un modelo de regresión dinámico para datos de panel con la metodología de momentos generalizados de sistema (system GMM). Los datos son de frecuencia anual y abarcan el periodo 2011-2018, para cada uno de los departamentos del Perú. La criminalidad se mide como el número de crímenes denunciados por cada 1 000 habitantes, mientras que los factores socioeconómicos considerados son la educación, la informalidad, el nivel de ingresos y la tasa de desempleo. Los resultados indican que un mayor número de instituciones educativas, menores niveles de informalidad y menores niveles de desempleo predicen una reducción de los índices de criminalidad; sin embargo, los ingresos no contribuyen en la predicción de los índices de criminalidad.
Efectividad de métodos de disuasión para disminuir el número de aves marinas en el muelle de la planta Perú LNG, Pampa Melchorita
Authors:   , Ponce Garcia Lucia Alejandra
Published: November 2022

RESUMEN. Desde el término de la construcción de las instalaciones portuarias de la planta de Perú LNG (Melchorita, km 163 Carretera Panamericana Sur) en 2009, se produjo un cambio ecológico notorio en el ambiente costero-marino de Melchorita. Diferentes especies de aves marinas encontraron un hábitat y condiciones propicias para su ocupación. Sin embargo, la presencia de estas aves genera el acumulo de heces sobre las estructuras marítimas ocasionando el desgaste de las mismas. El objetivo de esta investigación fue evaluar la efectividad de tres métodos de disuasión, para reducir este impacto: 1) Mallas que cubren el tramo del gaseoducto que pasa por el muelle, 2) líneas de nylon en las plataformas de descanso de las aves y 3) disturbio periódico generado por personal conocido como gavieros, para disminuir el número de aves de las tres especies más representativas de las instalaciones portuarias de Melchorita: zarcillo (Larosterna inca), cormorán neotropical (Phalacrocorax brasilianus) y pelicano peruano (Pelecanus thagus). El estudio se llevó a cabo mensualmente entre agosto 2017 y febrero 2019 por medio de conteos de las aves ante los diferentes efectos a medir. Las mallas en el tren del muelle resultaron efectivas en reducir la densidad de zarcillos (zonas sin malla: 16.05 ± 3.31 aves/m2, zonas enmalladas: 3.88 ± 0.56 aves/m2) y cormoranes (zonas sin malla: 1.50 ± 0.51 aves/m2, zonas enmalladas: 0.07 ± 0.03 aves/m2). Asimismo, las líneas de nylon en las plataformas de descanso fueron también efectivas en reducir el número de zarcillos (antes de la colocación: 75.47 ± 18.38 aves, después de la colocación: 1.25 ± 0.57 aves). Sin embargo, el disturbio de los gavieros, no tuvo un efecto significativo sobre los zarcillos (100% de las aves retornaron al mismo lugar, antes de 30 min), pero si sobre los pelícanos (solo 16% de las aves retornó) y cormoranes (21%).
Aplicación y eficiencia del uso de fórmulas de tamaño de muestra en ensayos clínicos aleatorizados publicados en revistas de alto factor de impacto en ortodoncia
Authors:   , Calderon Augusto Marialicia
Published: November 2022

Introducción: El propósito de este estudio fue determinar la frecuencia de aplicación y la pertinencia en el uso de fórmulas de tamaño de muestra utilizadas en ensayos clínicos (EC) publicados durante los años 2015-2019 en las revistas de ortodoncia de más alto factor de impacto. Métodos: Este estudio transversal evaluó 142 EC publicados durante los años 2015-2019 en las cuatro revistas de mayor factor de impacto de la ortodoncia según el ranking SCIMAGO 2018. Se incluyeron EC aleatorizados y realizados en seres humanos. Dos ortodoncistas entrenados y calibrados evaluaron si los EC seleccionados reportaron el cálculo de muestra y si estos describieron los criterios de su cálculo adecuadamente, incluyendo el tipo de test, nivel de significancia, poder de la prueba, precisión o tamaño del efecto (diferencia clínicamente relevante) y varianza. Se determinó un cálculo adecuado cuando reportaron por lo menos 4 de 5 criterios señalados. Se utilizaron las pruebas de chi cuadrado y regresión logística binaria. Resultados: 120 publicaciones (84.5%) reportaron el cálculo de muestra en su redacción, pero solo 61 (50.8%) reportaron adecuadamente el cálculo (por lo menos 4 de 5 parámetros). Fallaron en reportar el tipo de test 101 (84.2%), el nivel de confianza 10(8.3%), el poder de prueba 3 (2.5%), no precisaron el detalle de la obtencion del tamaño de la muestra 38 (31.7%). Sólo 9 (7.5%) cumplió con describir todos los 5 parámetros evaluados. Finalmente, de los trabajos que habían usado un cálculo de muestra solo 96 (80%) superaba el mínimo tamaño de muestra requerido. Por lo tanto 24 (20%) no cumplió lo mínimo requerido. Cuando se evaluó si el año de publicación estuvo relacionado a la pertinencia del reporte se encontró que por cada año que pasó, hubo 1.301 veces más probabilidad de reportar inadecuadamente el cálculo de muestra (P=0.048). Conclusiones: Los EC…
Transcriptomic analysis of differentially expressed genes between uterus and ovary in Xiangxi cattle
Authors: Song Wu , Li Jianbo , Sun Ao , Long Yun
Published: November 2022

Reproductive efficiency of a heifer is directly dependent on the health of reproductive system especially ovary and uterus. Current experiment was carried out to screen candidate genes related to reproductive traits and detect molecular mechanisms of DEGs by using RNA-sequencing (RNAseq) and Gene Set Enrichment Analysis (GSEA) to understand the environmental adaptability, molecular breeding and analyze the reproductive performance. Furthermore, Illumina II high throughput sequncing technology was utilized in the current experiment to sequence transcriptomes and analysis related to pathway of different genes between uterus and ovary in Xiangxi cattle. The total number of ovary assembled was compared to the reference genome sequence, DEGs analysis, GO and KEGG enrichment analysis and candidate gene screening were performed. Based on the transcriptome data, seven cDNA libraries were constructed by utilizing total RNA. Out of seven contracted cDNA libraries, in every sequencing library, raw reads reached >133 Mb, and >94% clean reads remained. After comparing the Xiangxi cattle ovaries with the uterus, a total of 3635 mRNAs were found, in which 1608 were significantly up-regulated expressed and 2027 were down-regulated expression mRNAs. The mRNA expression of ADCY3, ADCY4, ADCY9, FSHR, BMP15, LHCGR, INSR, CYP11A1, CYP17A1, CYP19A1, STAR and SCARB1 in ovary of Xiangxi Cattle were significant different in ovarian and uterus tissues. Through GSEA and PPI network, we found the ovarian steroidogenesis pathway played significant role in signal regulation during the development of the ovarian tissue of the Xiangxi cattle
Ecological and physiological characteristics of Pinellia ternata under different shade conditions
Authors: Na Zhao , Qingguo Xu , Xu Wang
Published: November 2022

To investigate the ecological, yield, physiological, and biochemical index of cultivated pinellia under different shade conditions and to analyze the influence of light intensity on Pinellia ternata’s ecological and physiological characteristics, our experiment employed four varieties of pinellia, Changde pinellia, Yuanling pinellia, Ziyang pinellia, and Bijie pinellia, as experiment materials, planted them under equivalent growing conditions, and placed them under different shade conditions (shade net settings of 0%, 25%, 50%, and 75% shade). The present study sought to determine the index changes of pinellia, including their morphology, photosynthesis, antioxidant enzyme activity, and yield, over a 100-day growth period. The results under 25% shade, compared with full light, revealed the following: pinellia plants reached heights of up to 20.04 cm, an increase of 43.35%; the maximum leaf area was 16.15 cm2, an increase of 34.78%; and the fresh weight of pinellia tubers decreased to varying degrees. Under shade treatment, the content of chlorophyll in pinellia leaves increased, the content of soluble protein and malondialdehyde decreased, and the activities of three antioxidant enzymes increased; these changes were overall consistent with the typical characteristics of shade plants, and the adaptability of pinellia to different shade conditions varied considerably. Moderate shade (25%–50% shade) could improve the physiological and ecological indicators of pinellia and reduce the threat of intense light exposure, but it would also reduce the tuber yield to varying extents
Hepatitis C–Seropositive Liver Transplants: A Multimethod Study to Evaluate Protocol Implementation
Authors: Martin Matthew , Faulkner Sherilyn A. , Suri Yash , Aqel Bashar , Pungpapong Surakit , Leise Michael , Dickson Rolland
Published: November 2022

Background: Starting in November 2017, 3 liver transplant centers in a single health care system tested and implemented a new protocol to begin accepting livers from hepatitis C virus–seropositive donors for seronegative liver transplant recipients. Although reports show an increase in donors after protocol implementation, there are no details regarding protocol uptake at each transplant center. Literature is limited on protocol implementation that is developed and disseminated by the same protocol producers. The purpose of this study was to evaluate the implementation of a new liver transplant protocol adopted at 3 transplant centers in the same health care system.
Methods: A multimethod implementation study using interview, survey, and transplant data was conducted to develop a conceptual model of protocol implementation, identify facilitators of and barriers to implementation, and detect differences in implementation between 3 centers.
Results: The conceptual model included 4 domains: rationale, development, implementation, and sustainability. Facilitators included clear, science-based rationale, input from multiple hepatologists, leadership support, and funded pilot data. Barriers included insurance coverage of posttransplant medication and donor field availability. A total of 94 physicians and staff at the 3 transplant centers completed the survey. Implementation factors were all rated moderately high to high at all 3 centers. One-way analysis of variance showed significant differences in mean implementation scores between the centers (F(2, 84)=11.65; P<.001) and between physicians at the 3 centers (F(2, 23)=4.65; P=.02); post hoc comparisons indicated that the scores for physicians differed only between the leading center and 1 participating center. Transplant numbers increased across all 3 centers from 2017 to 2021.
Conclusions: Protocol implementation was successful across all 3 centers, especially at the leading transplant center where the protocol was developed. Future efforts should examine the appropriateness of the protocol for other organs (eg, heart, kidney) and additional medical outcome data (eg, mortality, morbidity, quality of life).
Trial Registration: Not applicable
Genome-Wide Analysis of Circular RNA-Mediated ceRNA Regulation in Porcine Skeletal Muscle Development
Authors: Yun Jiale , Huang Xiaoyu , Liu Chang , Shi Mingyue , Li Wenxia , Niu Jin , Cai Chunbo , Yang Yang , Gao Pengfei , Guo Xiaohong , Li Bugao , Lu Chang , Cao Guoqing
Published: November 2022

Background: As a diverse and abundant class of endogenous RNAs, circular RNAs (circRNAs) participate in various biological processes including cell proliferation and apoptosis. Nevertheless, few researchers have investigated the role of circRNAs in muscle development in cultivated pigs.
Results: In this study, we used RNA-seq to construct circRNA expression profiles in skeletal muscle of Jinfen White pigs at the age of 1, 90, and 180 days. Among the 16,990 identified circRNAs, 584 were differentially expressed, with 255, 477, and 63 DE circRNAs in the 90 d vs. 1 d, 180 d vs. 1 d, and 180 d vs. 90 d groups, respectively. Moreover, Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses of DE circRNA host genes revealed them to be mainly involved in skeletal muscle fiber-related processes (e.g., muscle contraction, muscle organ development, and muscle system processes) and skeletal muscle fiber-related signaling pathways (e.g., AMPK and cAMP pathways). We also constructed circRNA–miRNA–mRNA co-expression network to screen out circRNAs many involved in the regulation of porcine skeletal muscle growth and development through the competitive endogenous RNA (ceRNA) mechanism. In this network, we predicted circ_0018595 may as a potential sponge of miR-1343 to regulate PGM1 expression, in turn promoting the proliferation of pig skeletal muscle satellite cells. The structure and expression of circ_0018595 were confirmed using convergent and divergent primer amplification, RNase R digestion, and qRT-PCR.
Conclusions: This study has identified 584 candidate circRNAs, especially circ_0018595, which may be involved in the growth and development of porcine skeletal muscle, and will therefore serve as a valuable resource for further in-depth study of circRNA regulatory mechanisms in skeletal muscle development.
Adding insult to injury: anthropogenic noise intensifies predation risk by an invasive freshwater fish species
Authors: Marina Fernandez Declerck , Emilie Rojas , Loïc Prosnier , Loïc Teulier , François-Xavier Dechaume-Moncharmont , Médoc Vincent
Published: November 2022

The ecological impact of invasive species is likely to be modulated by human-induced alterations in habitats, which represents another driver of biodiversity loss. We tested the effect of soundscape degradation on predation by the round goby Neogobius melanostomus, one of Europe’s “worst invasive species”. For this, we compared the relationship between per capita predation rate and prey density (i.e., the functional response) in the presence or absence of motorboat sounds. Unexpectedly, fish displayed a stronger functional response with additional noise, which could be explained by a higher mobility promoting encounters with prey. Our results suggest that anthropogenic noise is likely to exacerbate the impact of invasive species.
Genetically predicted obesity and risk of hip osteoarthritis.
Authors: Yuan jiaqin , Wang Dejie , Zhang Yaqiang , Dou Qiang
Published: November 2022

Objectives: To determine the causal association between genetically predicted obesity and the risk of hip osteoarthritis.
Methods: We performed two-sample Mendelian randomization (MR) analysis to analyze the association between body mass index (BMI) and hip osteoarthritis using pooled-level genome-wide association study (GWAS) data. The inverse variance weighted (IVW), MR‒Egger, and weighted median methods were used to estimate the causal association. In addition, we applied the MR Steiger filtering method, MR robust adjusted profile score (MR.RAPS) methods, and the MR Pleiotropy RESidual Sum and Outlier (MR-PRESSO) global test to examine and address potential horizontal pleiotropy.
Results: We found a causal relationship between genetically predicted BMI and the risk of hip osteoarthritis by the IVW method [OR=1.45, 95% confidence interval (CI) = 1.04-2.00, P = 0.02]. In the sensitivity analysis, the results of the MR‒Egger and weighted median methods revealed similar estimations but with a wide CI with lower precision. The funnel plot, MR–Egger intercept, and MR-PRESSO all indicated the absence of a directional pleiotropic effect. In addition, no heterogeneity was observed in the present analysis. Therefore, the result of IVW is most suitable and reliable for the present MR analysis.
Conclusion: There is a causal relationship between obesity and a higher risk of hip osteoarthritis, suggesting that weight management may be an intervention for the prevention and management of hip osteoarthritis.
Fear of childbirth and its relationship with anxiety and depression among Iranian fathers: a cross-sectional study
Authors: Rashidi Fatemeh , Mirghafourvand Mojgan , Malakouti Jamileh
Published: November 2022

Background: In addition to mothers, fathers may find the perinatal period difficult and complicated and experience a wide variety of emotions such as fear, anxiety, and depression. These emotional changes can adversely affect a father’s relationships with his infant and wife. Although most of the mental health problems experienced by fathers have generally been assessed in developed countries, there are insufficient data in developing countries. Hence, this study aimed to determine the fear of childbirth and its relationships with anxiety and depression among Iranian fathers.
Methods: In this cross-sectional study, the cluster sampling method was employed to enroll 302 husbands of pregnant women visiting health centers in Tabriz, Iran, in 2022. The data collection tools were the Sociodemographic and Obstetric Characteristics Questionnaire, Paternal Fear of Childbirth Scale, Spielberger’s State-Trait Anxiety Inventory (STAI), and Edinburgh Postnatal Depression Scale (EPDS). To assess the relationships of fear of childbirth with depression and anxiety, Pearson correlation tests was conducted in a bivariate analysis, and the general linear model (GLM) (with adjusting sociodemographic and obstetric characteristics) was employed in a multivariate analysis.
Results: The mean (±SD) of paternal fear of childbirth score was 48.39 (±14.10) within the possible 17–85 range. According to Pearson correlation test results, fear of childbirth had significant direct correlations with depression (P< 0.001; r= 0.47), state anxiety (P< 0.001; r= 0.60), and trait anxiety (P< 0.001; r= 0.51). The adjusted GLM results indicated that an increase in fear of childbirth score significantly increased depression (B= 0.18; 95% CI:0.13 to 0.22; P< 0.001), state anxiety (B= 0.45; 95% CI: 0.38 to 0.53; P< 0.001), and trait anxiety (B= 0.35; 95% CI: 0.27 to 0.42; P< 0.001) scores obtained from participants.
Conclusions: The research results indicated that paternal fear of childbirth significantly affected paternal anxiety and depression levels in the perinatal period. Therefore, it is recommended to develop comprehensive programs to screen fathers for fear of childbirth and psychological problems and to implement appropriate preventive and therapeutic interventions.
Prevalence and risk factors of hypertension in adolescents: a cross-sectional study based on junior high schools in southwest China
Authors: Huang Yuqin , Zheng Hongyu , Qin Suyuan , Chen Cheng , Su Danyan , Ye Bingbing , Huang Yanyun , Pang Yusheng
Published: November 2022

Background
Hypertension in children and adolescents has become a major public health problem worldwide. However, due to the lack of epidemiological data and the absence of clear risk factors for hypertension, it is likely that many pediatric hypertensive patients are not correctly identified and given adequate attention. This study aimed to investigate hypertension prevalence and risk factors in adolescents in southwest China.
Methods
A junior high school-based cross-sectional study was conducted involving a total of 886 pupils (466 males and 420 females) aged 11 to 14 years in the first and second grades of two schools. Height, weight, waist circumference, skinfold thickness, and blood pressure (BP) were measured according to standard protocols, and blood samples were collected for uric acid (UA), total cholesterol (TC), triglycerides (TG), low-density lipoprotein cholesterol (LDL-c), and high-density lipoprotein cholesterol (HDL-c). Multivariate logistic regression analysis was used to find the risk factors associated with hypertension, and multiple linear regression analysis was used to find the factors affecting systolic and diastolic BP.
Results
The overall prevalence of hypertension and elevated BP was 14.4% and 16.9%, respectively. Obesity (OR: 5.73, 95%CI: 3.27–10.03) and overweight (OR: 2.33, 95%CI: 1.54–3.52) were associated with hypertension. Hdl-c (standardized β = 0.098, p = 0.001) and TC (standardized β = 0.075, p = 0.023) were associated with systolic and diastolic BP, respectively.
Conclusions
The Chinese junior high school students who participated in the survey had a high prevalence of hypertension related to obesity and overweight. Notably, dyslipidemia may have influenced the development of hypertension.
Species Diversity of Lichens on the Territory of the Burabay National Park (Republic of Kazakhstan)
Authors: Bukabayeva Zhanilxan , Abiev Sardarbek , Korolev Alexander
Published: November 2022

The article provides an analysis of the distribution of lichen species across 11 test sites laid on the territory of the Burabay National Park in 2018–2019. The total area of the Burabay National Park is 129.3 thousand hectares, where more than 700 vascular plants grow. It was formed in 2000 in the northern part of the Republic of Kazakhstan in order to preserve the unique natural complex and use it for recreational, scientific and cultural purposes. It is part of the Shchuchinsko-Borovskaya resort area. Geographically, it is an island-type ring structure, which is an oasis surrounded by expanses of steppes. On the territory of the Burabay National Park there are multiple large lakes: Borovoe, Shuchye, Maloe and Bolshoe Chebachye, Maybalyk, Katarkol. To identify the full species composition of lichens, all types of substrates were examined on the test areas: the surface of trunks and branches of trees of different species and conditions (live, dry, dead wood), rotting wood, soil, stones. 44 species of lichens belonging to 9 families and 19 genera have been identified in the vicinity of the National Park. The taxonomic composition of lichenobiota is as follows: Peltigeraceae (3 species), Teloschistaceae (3), Lecideaceae (3), Physciaceae (5), Parmeliaceae (14), Cladoniaceae (13). The families Dermatocarpaceae, Verrucariaceae, and Lecanoraceae include one species each. The largest number of species of the National Park Burabay are represented by epiphytes.
The level of education is associated with an anxiety-depressive state among men and women – findings from France during the first quarter of the Covid-19 pandemic
Authors: Joannès Camille , Redmond Niamh M , Kelly-Irving Michelle , Klinkenberg Josephine , Guillemot Cassandra , Sordes Florence , Delpierre Cyrille , Neufcourt Lola
Published: November 2022

Context
It is widely recognised that the Covid-19 pandemic has negatively impacted individuals’ mental health. However, little emphasis has been put on the possible influence of socio-economic factors in the relationship. In the context of the COVID-19 pandemic, our objectives were (i) to assess the relationship between education level and mental health in French adults, and (ii) to study the influence of the economic, social, health and the COVID-19-related factors in men and women respectively.
Method
Data are from 32,581 individuals representative of the French population who responded to the weekly survey “Baromètre COVID-19” between April 7th and May 31st 2020. Education level was self-reported (university degree, high school qualification, vocational certificate/qualification, no diploma). Anxiety-depressive state was derived from four items related to the frequency of occurrence of depressive and anxiety symptoms, and summarized in an overall validated anxiety-depressive score. Multivariate linear regression analyses were carried out with nested adjustments of variables related to economic, social, health and Covid-19 contexts to assess the relationship between education and anxiety-depressive state.
Results
In total, 45% of individuals reported symptoms of anxiety-depressive state (53% in women versus 36% in men). Among men, those with a vocational certificate/qualification and those with no diploma had a greater risk of having a higher anxiety-depressive state compared to those with a university degree (βVocational certificate/qualification=0.16 [0.04; 0.27]; βNo diploma=0.75 [0.43; 1.07]) while among women, the risk of anxiety-depressive state increased as education level decreased (βBaccalaureate=0.37 [0.25; 0.49]; βVocational certificate/qualification=0.41 [0.28; 0.54]; βNo diploma=0.8 [0.49; 1.12]).. For both men and women, economic, health, and Covid-19 factors partly attenuate these associations while social factors marginally modified the relationship. After accounting for confounders and intermediate variables, the absence of a diploma remained associated with anxiety-depressive state among men, while the whole educational gradient of anxiety-depressive state persisted among women.
Conclusion
In France, at the end of the first wave of COVID-19, individuals with a lower level of education had a higher risk of anxiety-depressive state. This association was more pronounced for women, highlighting a process of social inequality in health possibly related to gender. This should be considered in future prevention and public health interventions.
Fractal modeling of multivariate principal component of contaminating toxic elements in Irankooh Pb-Zn mining area
Authors: Mahdiyanfar Hossein , Seyedrahimi-Niaraq Mirmahdi
Published: November 2022

The primary purpose of this investigation is contamination mapping in surrounding areas of Irankuh Pb–Zn mine, located in central Iran, using an integrated approach of principal component analysis (PCA) with the Concentration-Area (C-A) and Power Spectrum-Area (S-A) fractal models. PCA categorized the 45 elements into eight principal components. Component 2, containing the toxic elements of Pb, Zn, As, Mn, Cd, and Ba, was identified as contamination factor. This multivariate contamination factor was modeled using the C-A and S-A fractal methods (in spatial and frequency domains) to delineate pollution areas. Modeling of PCA data using the C-A fractal method showed four main populations for contamination factors. Two populations with higher fractal dimensions are associated with contamination from mining activities or anthropogenic effects. Low fractal dimensions are considered the background population which has not been affected or is less affected by these activities. Five geochemical populations were obtained for contamination factors using the S-A fractal modeling of PCA in the frequency domain. Therefore, various geochemical populations were achieved using geochemical filtering and two-dimensional inverse Fourier transformation. The geochemical populations related to classes 2, 3, and 4 containing intermediate frequency signals showed the pollution anomaly. The spatial distribution of pollutant geochemical signals exhibits excellent conformity with the mining operation limit and tailing dam location as pollutant sources. The results indicate that the elements of Pb, Zn, Cd, and As have significant values in the surrounding soils rather than their concentrations in the earth’s crust. The results demonstrate that the S-A fractal models can more precisely delineate the environmental anomaly than the C-A fractal model, especially in intermediate frequency populations.
Cell Focusing and Rotation by a Planar Optoelectronic Tweezers
Authors: Gan Chunyuan , Zhang Jiaying , Zhao Jiawei , Wang Ao , Xiong Hongyi , Liang Shuzhang , Ji Yiming , Feng Lin
Published: November 2022

Optoelectronic tweezers (OETs) based on dielectrophoresis (DEP) force is a valuable tool for the manipulation of particles and cells. However, DEP-based methods that can measure the electrical parameters are always preformed on static metal electrode DEP systems. Here, we present a partitioned single-sided OET chip that combines an OET system and microfluidic channel. Unlike classical sandwich-structure OET chip, the single-sided chip is close to the metal electrode DEP system but can switch functions easily. Numerical simulations are studied to analyze the electric field on a microfluidic chip and pro-vide data for characterizing cell electric properties. The focusing and electro-rotation are successfully realized by partitioned multi-signal OET system. By analyzing the rotation speed, some specific electric param-eters of Raw cells are characterized. The work has laid a foundation for OET-based single-sided chip fabrication and experiment validation.
Study on the influence of guide vane angle on performance characteristics of reactor coolant pump during idling
Authors: Ye Daoxing , Zhai Fengli , Luo Yimin , Wu Jinchen , Chen Junlin , Lai Xide
Published: November 2022

In order to study the influence of different guide vane angle variation on performance characteristics of reactor coolant pump (RCP) during idling process, the external characteristics of RCP model with five different guide vane angles at idling process state were analyzed. Radial force characteristics and blade load characteristics of RCP were analyzed. The results show that the head and torque changes of pump with different guide vane angles in different idle period are consistent. The head of DY1model (Guide vane angle increases sharply first and then decreases gently, which convexity is large) is the highest and torque is small. The head drop rate of DY5 model (Guide vane decreases first and then increases, and the concavity is large) is the highest and torque is the largest. With the idling, the radial force of impeller and guide vane decreases gradually. The radial force of DY5 model impeller is small and the fluctuation range is weak. The radial force of DY4 model（Guide vane shows concavity change with gentle increase）impeller before idling is the largest. In the nonlinear transition of idle period, the total radial force of DY4 model is 235N when idling for 32s, which is nearly 30 times lower than that before idling, and the radial force decreases the most. In different idling periods, the radial force amplitude of guide vane of DY5 model is the largest, and the radial force decrease amplitude of guide vane of DY4 model is the largest in the whole idling period. The impeller blade load of DY4 and DY5 model pumps with concavity guide vane angle change law is significantly higher than that of other model pumps after the relative position of streamline is 0.6. When the relative position of the guide vane along the streamline direction is less than 0.5, the load fluctuation of the guide vane of each model pump is large. when the relative position is greater than 0.5, the blade load fluctuation is relatively small.
Government subsidies, land and sea enterprises collaborative cooperation and profit maximization
—— Differential Game Study Based on Data Simulation
Authors: Liu Xiaohao , Wu Shujuan , Hu Kaijun
Published: November 2022

Government subsidies are an important way to promote the cooperation between land and sea enterprises, but there is not much authoritative answer on how to quantitatively distribute government subsidies to increase the cooperation level and realize profit maximization of enterprises in land and sea. Based on the dynamic framework theory,differential game model based on government subsidies were constructed,the optimal equilibrium functions of land and land enterprises was obtained.The results show that:(1)Before government the cooperative effort of the land and sea enterprises and profit optimization of the land enterprises under cooperative game is maximization,but the profit optimization of the sea enterprises under cooperative game is minimization. (2)Government subsidies can effectively improve the cooperative effort and achieve profit and social optimization of the land and sea enterprises in The Nash non-cooperative game and the master-slave game,these cooperative effort is equal to the cooperation game and these profit optimization is greater than the cooperation game.(3) However, the optimal subsidy of sea enterprises under master-slave game and land and sea enterprises under cooperative game is zero, and the increasing government subsidy is not conducive to social benefit optimization.So, guiding land and sea enterprises to form cooperative game is the best choice to minimize the financial burden and maximize profit maximization.
Hope Experiences in Parents of Children With Cancer and Affecting Factors
Authors: Koyu Hazal Ozdemir , Algül Gökce , ALTAY Naime , TORUNER Ebru KILICARSLAN
Published: November 2022

The authors have requested that this preprint be removed from Research Square.
Subcellular distribution of prohibitin in rat liver during liver regeneration and its cellular implication
Authors: Sun Qingju , Shi Dachuan , Yao Xue , Shi Lei , Jiao Binghua , Liu Tao
Published: November 2022

Introduction and Objectives:
Little is known about Prohibitin (Phb1)’s role during liver regeneration (LR). Previously, we found that the expression of Phb1 was down-regulated in rat liver mitochondria at 24 h after 70% partial hepatectomy (PHx) based on subcellular proteomic analysis. Here, we further explored the potential role of Phb1 during LR.
Materials and Methods
The changes in the expression of mRNA and protein levels, subcellular distribution and abundance of Phb1 in rat liver during LR were observed after 70% PHx. Mitochondrial alterations and the level of apoptosis were observed through electron microscopy and flow cytometry. RNA interference-mediated knockdown of Phb1 (PHBi) was carried out in BRL-3A cells.
Results
Comparing with sham-operation control groups, Phb1 mRNA and protein levels were down-regulated at 24 h, up-regulated at 72 h and 168 h in 70% PHx test groups. Phb1 was mainly located in mitochondria, where its abundance was reduced at 24 h, significantly increased at 72 h and almost recovered to normal at 168 h. Phb1 was also located in nucleus, where its abundance was increased continuously 72 h and 168 hours after 70% PHx.. The altered ultrastructure and reduced mass of mitochondria during LR were nearly recovered to normal at 168 h. PHBi in BRL-3A cells resulted in increased S-phase entry as well as the number of apoptotic cells, and disruption of mitochondrial membrane potential.
Conclusions
Phb1 may play a role both in maintaining mitochondrial stabilization and in regulating cell proliferation and apoptosis of rat liver cells during LR.
Development of Pangasius hypophthalmus polyculture production in Pakistan when cultured with freshwater and Chinese carps
Authors: Perveen Summia , Khan Noor , Rasool Fayyaz , Butt Mahrukh
Published: November 2022

Pond-based aquaculture has developed as the main aquaculture system and plays a pivotal role in providing food fish, nutrition, incomes, and livelihoods for various value-chain actors in Pakistan. However, this technology is mainly used in intensive monoculture and little knowledge is available on polyculture approaches in Pakistan. Therefore, this study was conducted to evaluate the growth and production of fish at the different species composition in polyculture. The experiment was conducted for 90 days at the department of Fisheries and Aquaculture UVAS, Lahore, Pakistan. There were three treatments each with three replications. In all treatments, the stocking density was similar at different species compositions. All the ponds were subjected to the same regime of feeding and fertilization. Fortnightly random sampling was done to adjust the feeding rate. In this study, the Pangasius hypothalamus, showed significant variations with a final weight of 385.34 g, in T1, and 318.50 g, in T3 compared to others. %weight gain and % SGR of pangasius were comparatively higher among other fishes in T1 and T3. FCR of pangas was recorded as 1.9, in T1, and 1.30, in T3, respectively which shows a better result as compared to the control and other groups. In addition, the polyculture of the pangas influenced the nitrate level which was increased in the high-density group as compared to low density and control. At the end of the trial, we observed the cortisol and glucose levels which showed non-significant variations among all treatments, which is a positive indicator that there was not any stress on pangasius in the polyculture system. Due to positive effects on growth parameters, it is concluded that the polyculture of pangas with only Indian and mixed (Indian and Chinese carp) could be tried to enhance the economic benefits in Pakistan.
Extreme rainfall in south and south west of Iran and its association with Atmospheric Rivers (ARs)
Authors: Omidvar Kamal , Sepandar Nesa , Khosravi Younes
Published: November 2022

Atmospheric rivers (ARs) are long narrow band of high water vapor flux that closely related to heavy rainfall. Flooding from heavy rainfall is one of the major hazards in south and south west of Iran. In this paper, the connection between ARs and heavy rainfall is analyzed by a methodology based on the vertically integrated water vapor transport (IVT). Heavy rainfall days are identified from the Iran Meteorological Organization (IRIMO) from 1987 to 2019. Our results suggest that, all inclusive heavy rainfall events over the south and southwest of Iran are associated with the contributions by the ARs and they matches tend to peak in the cool season. Larger IVT value in the region related to more precipitation and play important role in determining the amount of it. The IVT value intense when the AR crossed over the region. According to the results, there were four major sources of ARs that effected on south and south west of Iran generally include Gulf of Aden, the Red Sea, Arabian Sea and Soudan. The Red Sea is the most important source of moisture those intense ARs on their path in this region.