bluuebunny/crossref_metadata_2025 huggingface dataset:
Toxina Botulínica no Tratamento da Enxaqueca Crônica: Uma revisão sistemática
Authors: Mello Andriele do Prado , Jacociunas Laura Vicedo
Published: September 2023

A enxaqueca crônica é causada por alterações químicas do cérebro, dores unilaterais, pulsáteis de intensidade variável. A administração da toxina botulínica, neurotoxina produzida peloClostridium botulinum, é uma alternativa de tratamento. Existem diferentes preparações da toxina botulínica, capaz de inibir a liberação de acetilcolina, provocando uma inibição da contração muscular. O objetivo do estudo foi analisar a eficácia terapêutica da toxina botulínica no tratamento da enxaqueca crônica. Foi realizada uma revisão sistemática utilizando como ferramenta embasadora o método de Principais Itens para Relatar Revisões Sistemáticas e Meta-Análises, utilizando como descritores: enxaqueca crônica, toxina botulínica e tratamento. Foram analisados 21 artigos, sendo 6 metas-analises e 15 ensaios clínicos, 9 ensaios clínicos foram comparados a placebo e 6 a outras terapias. Os ensaios utilizaram uma variedade de doses de 75 até 260 UI, e incluíram pacientes com enxaqueca episódica e crônica, na qual a toxina mostrou maior eficácia. A toxina apresentou também um perfil bom de segurança, sendo relatados poucos efeitos adversos, que em geral foram leves ou moderados. O estudo concluiu que ensaios clínicos controlados indicam que a toxina botulínica tipo A foi eficaz no tratamento da enxaqueca crônica. Na comparação com os demais medicamentos demostrou eficácia semelhante perfil de tolerabilidade superior.
Covid-19: Como informações baseadas em evidências auxiliaram um hospital terciário durante o primeiro ano pandêmico
Authors: Castro Tázia Lopes de , Sforsin Andrea Cássia Pereira , Pinto Vanusa Barbosa , Arantes Tiago , Falcão Maria Alice Pimentel
Published: September 2023

Durante a pandemia de COVID-19, a necessidade por uma informação confiável, rápida e precisa desafiou os profissionais de saúde de todo o mundo. O objetivo deste trabalho foi avaliar e comparar as solicitações dos profissionais da saúde realizadas a um Centro de Informação Sobre Medicamentos (CIM) em um ano pré-pandêmico e durante o primeiro ano pandêmico.
Características clínicas e sociodemográficas dos usuários de um Centro de Atenção Psicossocial Infantojuvenil em Porto Alegre a partir do sistema de Gerenciamento de Consultas (GERCON)
Authors: Lima Antonella Cabrini de , Castan Juliana Unis , Lima Flávia Moreira
Published: September 2023

Desde maio de 2019, o acesso aos serviços especializados de saúde mental infantojuvenil do município de Porto Alegre ocorre através da regulação assistencial por intermédio do sistema Gerenciamento de Consultas (GERCON). O objetivo deste estudo foi caracterizar o perfil clínico e sociodemográfico dos usuários encaminhados para um Centro de Atenção Psicossocial Infantojuvenil (CAPSi) nos dois primeiros anos do GERCON.
Drug-drug interactions of immunosuppressants and other drugs in kidney post-transplant recipients
Authors: Umana-Rivas Mariel , Brito Evelin Soares de , Soares Letícia Santana da Silva , Freitas Geraldo Rubens Ramos de , Arimatea Gustavo Queiroz , Gonçalves Priscila Dias , Galato Dayani
Published: September 2023

Immunosuppressants (ISS) are the most crucial tools used in the therapeutic regimens of transplant recipients. Nevertheless, these drugs are not the only ones adopted by patients; therefore, knowing the possible drug-drug interactions (DDIs) between immunosuppressants and other drugs commonly used in kidney transplant recipients is essential to ensure the effectiveness and safety of treatments. In this way, the objective is analyzing the DDIs between the immunosuppressants and other commonly used medications on kidney transplant adult recipients with active medical records undergoing post-transplant follow-up for 4.4 years (mean).
Right Ventricular Outflow Tract Obstruction in Twin-to-Twin Transfusion Syndrome: A Systematic Review and Meta-analysis
Authors: Mustafa Hiba J. , Jawwad Muhammad , Mansoor Ayesha Iqbal , Pagani Giorgio , DAntonio Francesco , Khalil Asma
Published: September 2023

Objective: We aimed to investigate the incidence, prenatal
factors, and outcomes of twin-to-twin transfusion (TTTS) with right
ventricular outflow tract obstruction (RVOTO). Search Strategy:
A systematic search was conducted to identify relevant studies published
until February 2023 in English using the databases PubMed, Scopus, and
Web of Science Selection Criteria: Studies reporting on
pregnancies with TTTS and RVOTO were included. Primary outcome was
survival including fetal demise, neonatal death, and 6-months survival.
Secondary outcomes were incidence and prenatal risk factors.
Data Collection and Analysis. The random-effect model pooled
the mean differences or odds ratios (OR) and the corresponding 95%
confidence intervals. Heterogeneity was assessed using the
I value. Results: 17 studies
encompassing 4332 TTTS pregnancies of which 225 cases had RVOTO were
included. Incidence of RVOTO at time of TTTS diagnosis was 6%. 134/197
(68%) had functional pulmonary stenosis (PS) and 62/197 (32%) had
functional pulmonary atresia (PA). 27% resolved following laser and
55% persisted after birth. Of those persisting, 27% required cardiac
valve procedures. Risk factors were TTTS stage III (53% vs 39% in
no-RVOTO), stage IV TTTS (28% in RVOTO vs 12% in no-RVOTO), and DV
reversed a-wave (60% in RVOTO vs 19% in no-RVOTO). GA at laser and GA
at delivery were comparable between groups. Survival outcomes were also
comparable between groups including fetal demise of 26%, neonatal death
of 12%, and 6-months survival of 82% in RVOTO group. Findings were
similar when subgroup analysis was done for studies including
head-to-head analysis. Conclusions: RVOT occurs in about 6% of
the recipient twins with TTTS, especially in stages III and IV and those
with reversed DV a-wave. The findings from this systematic review
support the need of a thorough cardiac assessment of pregnancies
complicated by TTTS, both before and after laser in order to maximize
perinatal outcome and the importance of early diagnosis of TTTS and
timely management. Tweetable abstract: Meta-analysis shows that
the incidence of right ventricular outflow tract obstruction among TTTS
pregnancies is 6%, among which 68% had functional pulmonary stenosis
and 32% had functional pulmonary atresia. Of these pregnancies, 27%
resolved after laser therapy and 55% persisted after birth. Of cases
persisting after birth, 27% required cardiac valve procedures.
Significant risk factors were TTTS stage III-IV and ductus venosus
a-wave reversal. Survival outcomes including fetal demise, neonatal
death, and 6-months survival were similar compared to those without
RVOTO.
Evaluation of Aqueous Methanol Stem Bark Extract of Stereospermum kunthianum for Wound Healing Effects in Alloxan-induced Diabetic Rats
Authors: Ifeadi Chekwube , Nwinyi Florence , Ode Julius , Onah Jonas , Babatunde Ramon-Yusuf
Published: September 2023

• BACKGROUND AND PURPOSE: The stem bark of Stereospermum kunthianum is
used extensively in traditional medicine to treat wounds, inflammatory
and other pain related health conditions in humans. The aim of this
study was to evaluate the wound healing properties of the stem bark
extract of S. kunthianum in alloxan-induced diabetic rats. •
EXPERIMENTAL APPROACH: The aqueous methanol extract of S. kunthianum was
analyzed for phytochemical constituents, acute toxicity tests in rats.
The stem bark extract of S. kunthianum was evaluated for wound healing
using excision and incision wound healing models in diabetic rats. • KEY
RESULTS: The aqueous methanol extract of S. kunthianum revealed that
saponins, terpenes, tannins and steroids were present. The acute
toxicity study in rats up to 72 hrs. showed no observed toxicity sign up
to the dose of 5000 mg/kg .The S. kunthianum stem bark extract (100,
200, 400 mg/kg, p.o) caused significant reduction of wound area. The
excision wound contraction (%) in rats treated with S. kunthianum stem
bark extract was most effective and had 100% wound contraction. In the
incision wound studies, the S. kunthianum stem bark extract showed a
progressive rate of wound repair with increasing doses of the extract. •
CONCLUSION: The results corroborated the ethno-medicinal claims and have
given the scientific justification for the use of S. kunthianum stem
bark extract for wound healing. • IMPLICATION: The S. kunthianum stem
bark extract therefore has the potential to be developed as a wound
healing agent.
Graph Algorithmic Thinking for the Wow! Signal. The First Contact.
Authors: Vashakidze Gizo
Published: September 2023

The major objective of this study is to decode the “Wow!” signal -
converting it into textual content. A novel feature of the present work
consists in a unique approach. When considering the recorded Wow! signal
not only the 6 signals received on channel #2 are taken into account,
but also total content of the 12 signals received on six different
channels as a result of which we got an infographic image. In this
study, an algorithmic method was used. The interpretation of the
infographic image includes the content similar to the brief
characteristic of the solar system. Hence, our cosmic address in this
infinite universe is fixed. The distance from the Sun to one of the
celestial objects is also recorded (19.9 light-years). The researchers
from the Big Ear radio telescope report that at the moment of picking up
the signal, the scanning of the sky took place towards the constellation
Sagittarius. The binary pair – J. Herschel 5173 AB – is located at
approximately the same distance in the indicated direction. According to
the calculations of astronomers, the mentioned binary pair of stars and
the Sun are approaching each other. The infographic representation of
the radio signal displays the same information.Therefore, a rare
phenomenon - the stellar convergence can be considered as the motivation
for beginning written communication. Thus, we arrived to the conclusion
that the aforementioned binary pair may be viewed as a potential star
the alien Wow! signal had come from.
Care Bundles and Peripheral Arterial Catheters: A Scoping Review
Authors: Reynolds Heather , Gowardman John , Woods Christine
Published: September 2023

Highlights

What we know about the topic: Recommendations for the use of vascular access care bundles to reduce infection are followed for different devices. The risk of arterial catheter-related infection is comparable with short-term, non-cuffed central venous catheters. There are practice concerns for clinicians inserting and caring for peripheral arterial catheters.

What this paper adds: The selected studies had a theme of decreased infection after using bundled strategies for all devices. Few studies addressed use of bundles for care of peripheral arterial catheters. High quality research should be performed about using care bundles for insertion and care of arterial catheters.

Introduction:

A scoping review of the literature was performed.

Aims/Objectives:

To find information on the use of care bundles for care of arterial, central, and peripherally inserted venous catheters.

Methods:

Data was extracted by 2 independent researchers using standardized methodology

Results:

Results of 84 studies included 2 (2.4%) randomized controlled trials, 38 (45.2%) observational studies, 29 (34.5%) quality projects, and 15 (17.9%) reviews. Populations had more adults than pediatric patients. All studies had the most prominent theme of decreased infection in all devices after using bundle strategies.

Discussion and Conclusions:

The mapping of available evidence strongly supports the use of care bundles to reduce infection in the care of all intravascular devices. However, deficiencies regarding practice concerns about insertion and care of arterial catheters highlight areas for future research with the aim to eliminate the gap in the evidence of studies of care bundles for peripheral arterial catheters.
The Effectiveness of Shared Decision-making for Diabetes Prevention: 24- and 36-Month Results From the Prediabetes Informed Decision and Education (PRIDE) Trial
Authors: Duru O. Kenrik , Mangione Carol M. , Turk Norman , Chon Janet , Fu Jeffery , Cheng Grace , Cheng Felicia , Moss Amanda , Frosch Dominick , Jeffers Kia Skrine , Castellon-Lopez Yelba , Tseng Chi-Hong , Maranon Richard , Norris Keith C. , Moin Tannaz
Published: September 2023

OBJECTIVE

We conducted a cluster-randomized, shared decision-making (SDM) trial offering lifestyle change, metformin, or both options, to adults at risk for diabetes in a primary care network (n = 20 practices).

RESEARCH DESIGN AND METHODS

We used propensity score matching to identify control patients and used electronic health record data to compare weight loss at 24 and 36 months of follow-up and diabetes incidence at 36 months of follow-up.

RESULTS

In adjusted post hoc analyses, SDM participants (n = 489) maintained modestly greater 24-month weight loss of −3.1 lb and 36-month weight loss of −2.7 lb versus controls (n = 1,430, both comparisons P < 0.001). SDM participants who chose both lifestyle change and metformin sustained weight loss at 36 months of −4.1 lb (P < 0.001 vs. controls). We found no differences in incident diabetes (15% of SDM participants, 14% of control participants; P = 0.64).

CONCLUSIONS

This is one of the first studies to demonstrate weight loss maintenance up to 36 months after diabetes prevention SDM.
Conversa com o Professor Humberto Bortolossi
Authors: Nóbriga Jorge Costa , Carrazedo Dantas Sérgio , Bortolossi Humberto
Published: September 2023

O Professor Humberto Bortolossi é Licenciado em Matemática pela UEM, mestre em Matemática pelo IMPA e doutor em Matemática pela PUC-Rio. É professor Associado I da Universidade Federal Fluminense. Ele é uma das grandes referências no Brasil quando o assunto é GeoGebra. Foi o primeiro tradutor do GeoGebra para o português do Brasil, ajudando muito a divulgar e implementar o uso do software  no País. Certamente, também deveria ser um autor convidado para escrever um artigo para essa edição. Todavia, no momento que a revista começou a ser produzida, o Humberto não estava com condições de escrever. Dessa forma, optamos por fazer uma conversa online com ele e transcrevê-la.
Pensando e resolvendo problemas com o GeoGebra
Authors: Dantas Sergio Carrazedo
Published: September 2023

Este texto tem por objetivo apresentar minha história de uso do GeoGebra. Abordo seu emprego em situações de preparação de materiais para a sala de aula e na resolução de problemas. Utilizo como referencial o constructo teórico de Valente (2005) que trata do Ciclo de ações e da Espiral de aprendizagem. As ideias de Valente (2005) contribuíram para tematizar a utilização do GeoGebra em várias situações, tais como, preparação de materiais para a sala de aula e resolução de problemas. Além disso, possibilitou a constituição de uma noção sobre o pensamento computacional.
Amadurecendo como professor, pesquisador e colaborador com o GeoGebra
Authors: Gonçalves William Vieira
Published: September 2023

Neste texto, relato minha trajetória como professor, pesquisador e formador de professores, tendo como pano de fundo, minhas perspectivas como usuário do GeoGebra e membro de uma comunidade que busca aprender colaborativamente. Meu principal objetivo é compartilhar experiências e diferentes produções acadêmicas, incentivando professores de matemática a procurar maior envolvimento com o GeoGebra e formações continuadas similares ao Curso de GeoGebra.
Pregnancy and uterine fibroids (leiomyoma): a critical review
Authors: Fatkullin I. F. , Orlov Yu. V. , Fatkullina L. S. , Korennaya V. V.
Published: September 2023

Here we review current opportunities in pregnancy management in women with uterine fibroids, also known as leiomyoma. Uterine fibroids are associated with a number of complications already at planning for pregnancy and also during pregnancy and labour. We discuss vaginal delivery and caesarian section in such patients, considering safety issue with regards to myomectomy and its expediency before pregnancy and during caesarean section. Multiple controversies and debates emphasize the need for the further research in this direction.
Development of an artificial intelligence system for the forecasting of infectious diseases
Authors: Kuzin A. A. , Glushakov R. I. , Parfenov S. A. , Sapozhnikov K. V. , Lazarev A. A.
Published: September 2023

Aim. Here, we provided an overview of artificial intelligence (AI) approaches for developing a system for prediction of infectious diseases and designed a respective step-by-step protocol.

Materials and Methods. Literature search in PubMed and Google Scholar and PubMed.

Key Points. Infectious diseases impose a heavy burden on a healthcare, demanding the development of novel and efficient approaches to prevention as well as sensitive and specific diagnostic tests. Evolution of data science have led to the emergence of promising artificial intelligence (AI) algorithms and tools for the forecasting of infectious diseases. Employing machine learning algorithms, AI systems can rapidly analyze a large amount of data, extract specific disease patterns, and screen for the most efficient AI instruments in relation to specific tasks, thus contributing to prevention, diagnostics, and treatment of infectious diseases in the context of personalized medicine. Importantly, such AI-based systems can determine specific human motor patterns from videos and/or photographs in order to assist physicians in primary diagnosis. Integration of AI tools into the existing healthcare algorithms can be especially useful for public health.
Dietary consumption of lipids as a potential risk factor for non-communicable diseases in Western Siberia
Authors: Turchaninov D. V. , Shirlina N. G. , Viktorova I. A. , Stasenko V. L. , Chubarova A. D. , Vilms E. A.
Published: September 2023

Aim. To assess the profile of lipid consumption in the population of Omsk Region, located in Western Siberia.

Materials and Methods. During 2019-2020, we have performed a cross-sectional survey in the adult population of the Omsk region (n = 441, age 18-83 years). Questionnaires included an information regarding the food intake, nutritional status, and health status. In addition, we measured body mass index, waist circumference and waist-to-hip ratio. Among the parameters, we evaluated average daily consumption of energy, fats, cholesterol, saturated, monounsaturated, and polyunsaturated fatty acids, phospholipids, linoleic acid, alpha-linolenic acid, and arachidonic acid. In addition, we assessed the ratio of omega-6 to omega-3 fatty acids in the diet, specific weight of vegetable fats, and the energy quotas of individual nutrients.

Results. In the population of Western Siberia, we found insufficient intake of alpha-linolenic acid (69.6 ± 2.2% population), arachidonic acid (55.3 ± 2.4%), polyunsaturated fatty acids (44.4 ± 2.4%), and phospholipids (37.6 ± 2.3%), as well as excessive consumption of cholesterol (74.1 ± 2.1%), total fats (61.9 ± 2.3%), saturated fatty acids (47.8 ± 2.4%), monounsaturated fatty acids (37.6 ± 2.3%), energy (34.7 ± 2.1%), and linoleic acid (31.1 ± 2.2%). In all groups of respondents, we registered high values of the omega-6/omega-3 ratio. The proportion of respondents with adequate consumption of energy and nutrients did not exceed 59.2 ± 2.3%.

Conclusion. The diet of the adult population in Western Siberia was characterized by dysbalanced lipid consumption (more than 60% of the population). We documented an insufficient consumption of polyunsaturated fatty acids and phospholipids in combination with excessive consumption of products containing cholesterol, saturated fatty acids, monounsaturated fatty acids, and linoleic acid.
Single or multiple arterial grafting to design a coronary bypass: a retrospective study
Authors: Frolov A. V. , Zagorodnikov N. I. , Tarasov R. S. , Grigoriev E. V.
Published: September 2023

Aim. To compare the efficiency of single arterial grafting (SAG) and multiple arterial grafting (MAG) at coronary artery bypass graft (CABG) surgery in the long term.

Material and Methods. To assess the angiographic outcomes, we evaluated the patency of 323 bypasses at 102 angiograms obtained during coronary angiography performed > 10 years post-CABG surgery.

Results. Out of 323 analyzed bypasses, 230 (71.2%) showed physiological functioning, whereas stenosis, occlusions, and other coronary artery alterations were found in 93 (28.8%) bypasses. The most common cause for the failure of anastomoses was competitive flow (most frequently registered in the anastomoses between left internal thoracic artery and left anterior descending artery, left internal thoracic artery and diagonal branches of left anterior descending artery, right internal thoracic artery and left anterior descending artery, and between right internal thoracic artery and right coronary artery), poor distal bed (most frequently revealed in the anastomosis between left internal thoracic artery and obtuse marginal artery, saphenous vein and diagonal branches of left anterior descending artery, saphenous vein and obtuse marginal artery, and between saphenous vein and right coronary artery), progression of atherosclerosis in combination with poor distal bed (most frequently detected in the anastomosis between right internal thoracic artery and obtuse marginal artery), and combination of poor distal bed, competitive flow, and graft degeneration (most frequently found in the anastomoses between radial artery and obtuse marginal artery and between radial artery and right coronary artery). In 5 (5.4%) cases, the cause of coronary bypass dysfunction was unclear.

Conclusion. The main causes for the coronary bypass failure included competitive flow (in case with multiple arterial grafting) and poor distal bed (in case with single arterial grafting).
ANALYSIS OF CLINICAL AND ANATOMICAL CHARACTERISTICS OF THE PEDESTRIAN ACCIDENT UNDER CONDITIONS OF THE CITY
Authors: Guryev S.O. , Kushnir V.A. , Grebeniuk V.I. , Soloviov O.S.
Published: September 2023

The purpose of the study – to determine and verify the extent of damage in victims oftraffic accidents (TA) under conditions of a regional city.Materials and methods. A retrospective analysis of 242 cases of injured persons, whoreceived damages as a result of a car accident and were treated in the emergency medicalcare hospital of Chernivtsi from 2019 to 2020, was conducted.The results. In the total file of the study, 28.51 % of victims have the range of damage oftwo anatomical and functional areas (AFA), 27.51 % – one, 24.38 % – three AFA. Amongthe survived victims, the same trend is observed – 30.32 % of the victims have damage oftwo AFAs, 26.56 % – one, and only 0.89 % have damage of six AFAs. Among the victimswho died, the highest specific weight falls on persons who have one and two damagedAFAs – 23.53 % each, and four and five AFAs – 17.65 % each. The highest mortality isobserved in victims with damage of five and six AFA – 33.33 % and 50.50 %, respectively.Damage of one and two AFAs is more typical for passengers (40.91 % and 40.58 %,respectively), and damage of four, five and six AFAs is more typical for pedestrians(37.14 %, 66.67 % and 50.0 % respectively).Conclusions. 1. Combined trauma (polytrauma) prevails in road accident victims in theconditions of a regional city – 72.72 %. 2. The largest specific weight in the array ofthose who died is the combination of three AFA (23.53 %), and in the array of those whosurvived – two AFA 30.22 %. 3. The sign of participation in traffic has a significant impacton the amount of damage in road accident victims, especially for pedestrians.
SPECIAL FEATURES OF INFLAMMATORY RESPIRATION WAYS DISEASES WITH THE INFLUENCE OF HYPOTHYROID STATUS AND ITS CORRECTION (REVIEW)
Authors: Kashul S.V. , Khukhlina O.S. , Andrusiak O.V. , Kovalenko S.V.
Published: September 2023

The purpose of the work – to analyze the literature data concerning the effect of reducingthe content of the thyroid gland (TG), as well as its correction with hormone replacementtherapy on the course of chronic obstructive pulmonary disease (COPD) and bronchialasthma (BA).Conclusions. On the basis of literature data, pathophysiological evidence of theinterrelationship of changes in thyroid status and chronic inflammatory process inthe respiratory tract (RT), as well as the effect of hormone replacement therapy forhypothyroidism on the course of these comorbid conditions, were established. Theanalyzed literary sources present the data of new studies: epidemiological, experimentaland clinical with the involvement of modern laboratory (immunological and molecularbiological in particular) and instrumental methods, which form a new point of view on therelationship between inflammation in the thyroid gland and hypothyroid status, and alsohighlight aspects of the influence of hormone replacement therapy on the development ofthe pathological process in RT with COPD and BA.
CELL DEATH: A MODERN VIEW OF APOPTOSIS AND AUTOPHAGY
Authors: Sribna V.O.
Published: September 2023

The purpose of the work – to analyze the literature data regarding the current state ofresearch on cell death, the relationship between the signaling pathways of apoptosis andautophagy in various pathologies, as well as the key mediators of both processes.Conclusions. Data from the literature indicate the existence of a clear relationshipbetween signaling pathways of apoptosis and autophagy in the conditions of variouspathological processes, which is carried out through key mediators, in particular, calcium(Ca2+), lipid rafts, ERLIN, PINK1, etc. Cell death is a promising therapeutic target forthe treatment of human diseases.
POST-TRAUMATIC STRESS DISORDER IN A SERVICEMAN AFTER RETURNING FROM RUSSIAN CAPTIVITY (CLINICAL CASE STUDY)
Authors: Nikoriak R.A.
Published: September 2023

In order to detect disorders in the emotional and volitional sphere in a serviceman, thechest test (ST), a non-burdensome method for detecting anxiety and depression NADS, thePCL-5 scale were used. The questions on this scale reflect the corresponding clusters ofPTSD symptoms according to the DSM-5 classification. Clinical-psychopathological andstatistical methods were also used.Using a screening test, it was established that the serviceman experienced severepsychological trauma related to the war, the memories of which are still «unrelenting».Using the NADS test, the patient was diagnosed with clinically expressed anxiety (14points) and subclinical depression (10 points). Interpreting the results of the study interms of clinically significant symptoms, in accordance with the PCL-5 scale, it wasconcluded that according to the total number of points and the sum of points calculatedby clusters of symptoms, the serviceman has post-traumatic stress disorder. The patientwas prescribed: psychopharmacotherapy (sedative antidepressant amitriptyline (50 mg),anxiolytic miaser (30 mg), anti-anxiety neuroleptic eglonil (50 mg)) and trauma- focusedcognitive- behavioral psychotherapy, which increased the patient’s resourcefulness. Asa result of the treatment, the patient’s condition improved within two weeks.
Evolution of shallow post-bog soils developed on Holocene carbonate sediments in NW Poland
Authors: Jarnuszewski Grzegorz , Meller Edward , Kitczak Teodor
Published: September 2023

This research presents the characteristics and inferred evolution of post-bog soils developed in the Last Glacial Maximum area of northwestern Poland near the southern Baltic coast. The study involved a total of five sites near existing lakes in NW Poland. In total, 21 soil pits were described and sampled and 17 piezometers were installed. In soil samples chemical and physical properties were determined. During the hydrological year the water level was checked and chemical properties of water were determined, the floristic composition at each location was also carried out. Mineralisation of post-bog soils initiated by dehydration leads to the decomposition of organic surface layers and an increase in CaCO3 content as well as mineral non-lime components at the expense of organic matter. A sequence of five soil types occurs in this landscape: Sapric Histosols (Limnic), Drainic Histosols (Calcaric, Limnic), Histic Gleysols (Murshic), Umbric Gleysols (Hyperhumic), Gleyic Phaeozems (Hyperhumic) that represent individual stages of soil genesis. Differences between the chemical properties of soils are apparent between organic vs organic-mineral and mineral layers. Man-induced drainage of post-bog soils changes their physical parameters. Bulk density increase and water retention decrease. The fluctuation of groundwater determines the moisture content of post-bog soils and affects the species composition of vegetation. Chemistry of groundwater is shaped mainly by the construction of catchment and the nature of its use, however, it is modified as a result of the inflow of macronutrients released during organic matter mineralisation processes and leaching of exchangeable forms from the sorption complex.
The water outflow from neighbouring mountain catchments in the Polish Carpathians: A comparative analysis
Authors: Kowalczyk Agnieszka W. , Jaguś Andrzej
Published: September 2023

The study covered water resources of two mountain streams in the Polish Carpathians. These were the Biała Woda and Czarna Woda streams, the catchments of which are adjacent to each other. Water flows in both streams were measured during the hydrological years from 2006 to 2020. Next, water outflows from the catchments were calculated. The study aimed to determine differences in the water resources of those catchments in a very small mountainous area. The study showed quantitative similarity in water resources in the entire multi-annual period but at the same time large differences in shorter periods. Instantaneous and daily outflows showed the largest differences, but differences in annual outflows of up to 20% were also recorded. Therefore, hydrological data from operational cross-sections to assess water resources of neighbouring uncontrolled watercourses should cover multi-annual mean values. It was found that during periods of increased runoff (from melting snow or precipitation), the outflow from the Biała Woda catchment was much larger, while during rain-free periods, the outflow from the Czarna Woda catchment prevailed. All short- term flood like outflows were at least several tens of per cent higher in the Biała Woda catchment. The higher retention capacity of the Czarna Woda catchment can be attributed to the land use (mainly forest areas). The results can be used for modelling catchments of similar parameters and determining their retention capacity.
Race and the political ecology of education in Brazil: A spatial analysis of rural school closures
Authors: Meek David , Daquin Jane , Paulon Girardi Eduardo , Fernandes Bernardo Mançano , Sobreiro do Filho José , Tarlau Rebecca , Vuelta Raquel
Published: September 2023

Education and processes of agrarian change are deeply imbricated processes. While political ecologists have begun exploring education in earnest, questions of race have remain largely unexplored. In this article, we analyze the spatial linkages between education, race, and the permanence of the peasantry in the face of expanding capital. Our focus is the crisis of rural school closures in Brazil. Over the last twenty five years, the state has closed more than 65% of Brazil’s rural schools. Social movements argue that these school closures are differentially occurring in communities of color. To better understand the factors driving this crisis, we assembled a “big data” database, consisting of twenty five years of municipal school records from every school in Brazil. Drawing upon advanced geospatial statistics and multiple linear regression techniques, we analyze both how these school closures are spatially patterned throughout Brazil, and the social, political, and economic factors shaping this crisis. Our results highlight land concentration and race as central dynamics in this crisis, underscoring the enduring impact that racial oppression and historical patterns of land inequality play in structuring the politics of knowledge and educational landscape in Brazil. 
An Analysis of the Structure of the Beekeeping Chain in the Territories of the State of Rio Grande do Norte (RN)
Authors: Da Silva Wellington Gaspar Ferreira , Da Silva Edinal Salustiano , Siqueira Elisabete Stradiotto , Siqueira Filho Valdemar , Nepomuceno Luciana Holanda , Nobre Liana Holanda Nepomuceno , Bispo Danielle de Araújo , De Brito Filho Arrilton Carlos
Published: September 2023

Purpose: The present research aims to analyze the organizational structure of the honey chain in the state of Rio Grande do Norte.
 
Method/design/approach: Semi-structured interviews were conducted with eight representative subjects from the beekeeping chain in the municipalities of Rio Grande do Norte. A descriptive qualitative approach was adopted to analyze the organizational relationships within the chain.
 
Results and conclusion: The results highlight challenges in regulating the honey production chain, suggesting improvements in governance through collaborative development of regulations. Additionally, it emphasizes the importance of associations and producer cooperatives in strengthening beekeeping, adding value, and overcoming commercial challenges. Certification was deemed more relevant for the chain links involved in honey processing and distribution.
 
Research implications: The study reveals that the various actors involved in the honey production chain in Rio Grande do Norte have significant disagreements regarding the interpretation of the legislation governing the production of this product.
 
Originality/value: The research contributes to understanding the organizational structure of the honey chain in Rio Grande do Norte, providing development strategies in the apiculture sector.
Contribuições da biologia molecular para identificação de sambaquis em áreas altamente impactadas pela urbanização
Authors: Leles Daniela , Lopes Mariana , Tizuka Michelle Mayumi , Saldanha Bruna , Chaves Sergio Augusto de Miranda , Klokler Daniela , Macário Kita , Garcia Anderson Marques , Gaspar Maria Dulce
Published: September 2023

A identificação taxonômica de ossos arqueológicos depende da integridade das peças, o que as vezes não ocorre em sítios altamente impactados pela urbanização. O objetivo da pesquisa foi elaborar um modelo experimental usando técnicas de biologia molecular para auxiliar na identificação de espécies de peixes possivelmente presentes no sambaqui da Prainha, localizado no centro da cidade do Rio de Janeiro, e de uma concreção do sambaqui de Camboinhas localizado na Região Oceânica de Niterói/RJ. Alvos moleculares universais para peixes foram usados no modelo experimental e material arqueológico. Não foi possível recuperar DNA de peixe do material arqueológico, mas isso não diminui os resultados encontrados. O modelo experimental se mostrou promissor, podendo ser aprimorado e usado futuramente em outras pesquisas zooarqueológicas.
La caza de otáridos en la Costa Oriental de Patagonia Austral en el Holoceno Tardío: estado de la cuestión y perspectivas de análisis
Authors: Cañete Mastrángelo Daniela Soledad , Muñoz A. Sebastián , Spataro Giuliana
Published: September 2023

Las interacciones entre poblaciones humanas y otáridos en la Patagonia austral abarcan un rango de variación aún no suficientemente conocido. La captura de estos mamíferos marinos debió involucrar una diversidad de tácticas y estrategias vinculadas a situaciones contextuales diversas. En este trabajo se presentan expectativas basadas en la biología y etología de estos animales y se discute la información arqueológica disponible en la desembocadura del río Santa Cruz durante el Holoceno tardío. Los resultados muestran que el tipo de presas elegidas fue variable, pero dentro del rango esperable por la abundancia natural de individuos, y la tecnología involucrada incluye un sistema de armas específico, combinado con otras tecnologías aplicables a la captura de diversas presas.
Rebanhos em objetos: histórias materiais das relações humano-animais nas aldeias indígenas no Brasil
Authors: Vander Velden Felipe
Published: September 2023

Este artigo apresenta um conjunto de artefatos indígenas (divididos em três categorias), que estão relacionados aos animais de rebanho introduzidos com a invasão europeia do Brasil a partir do século XVI. Partindo desses artefatos, potencialmente localizados tanto em contextos arqueológicos como em coleções musealizadas, discute-se várias possibilidades dentro de uma zooarqueologia histórica indireta das relações entre os povos indígenas e os animais exóticos, reconstituindo as fazendas indígenas para além de conjuntos osteológicos por meio de objetos manufaturados associados aos animais. O artigo defende múltiplos potenciais de integração entre pesquisas arqueológicas, antropológicas, históricas, zoológicas e iconográficas para se compreender as trajetórias das relações entre os povos indígenas e o gado nas terras baixas sul-americanas.
Unconventional Treatments for Mental Illness: Ketamine
Authors: Botea Alexander
Published: September 2023

Discussion on the use of ketamine as an unconventional treatment in the context of mental illness, focusing on its antidepressant and antisuicidal effects. Ketamine has limitations, such as a lack of antisuicidal context understanding, side effects, and short efficacy. However, research is being done to understand its functioning in suicidal context. Other therapies can help lower side effects, increase efficacy, and find safer administration. Ketamine could also be used as an initial response drug to buy time for suicidal patients and administer other treatments.
Breakthrough Study Develops Potential Cure for Hemophilia A
Authors: Cole Ella
Published: September 2023

A phase 1-2 clinical trial of hemophilia A gene therapy demonstrated that the oversized FVIII gene could be packaged into an AAV5 vector and provide sustained expression of the deficient factor VIII for long-term clinical benefit while producing no immune response.
Algunas consideraciones del Psicoanálisis sobre el malestar en relación al cuerpo
Authors: Ganem Emiliana , García Fabián Matías , Romero María Sol
Published: September 2023

El presente ensayo puntualiza algunas consideraciones sobre el Malestar en la cultura de Freud para referirse al trabajo clínico del malestar ligado al cuerpo. De acuerdo a lo planteado por este existe un malestar ineliminable y estructural para el cual hay posibilidades de tratamiento, aunque solo de modo parcial. Es parte del descubrimiento freudiano postular la existencia de un cuerpo que no coincide con el descrito por la anatomía, pero que, sin embargo, tiene una presencia fundamental en la clínica. Este cuerpo se hace presente en las palabras de quien consulta y es leído por la escucha analítica. A partir de ello se trabaja la propuesta lacaniana acerca del cuerpo como superficie que soporta inscripciones: el cuerpo es el Otro, en tanto sitio donde toma su lugar el significante. Se presentan, así, referencias clínicas para pensar cómo los pacientes consultan o abordan malestares referentes a sus cuerpos. Se sostiene, a partir de ello, que si el cuerpo es hablado, en la clínica puede ser leído como un texto y que es a partir de esta lectura, en la que aparece con fuerza su ajenidad, que podemos reflexionar sobre los tratamientos contemporáneos para confrontar su malestar.
PREVALÊNCIA DE TRANSTORNO DE ANSIEDADE E FATORES ASSOCIADOS EM CRIANÇAS DURANTE A PANDEMIA DA COVID-19: UM ESTUDO TRANSVERSAL
Authors: Borges Juliane Albernás , Reis Marina de Melo , Silva Filho Rodolfo Carlos dos Santos , Braga Thaynara Rosane Araujo , Cordeiro Jéssica Fernanda Corrêa , Andaki Alynne  Christian Ribeiro
Published: September 2023

O objetivo do estudo foi verificar a prevalência do transtorno de ansiedade e fatores sociodemográficos, comportamentais e aspectos de saúde associados em crianças de três a 10 anos de idade, durante a pandemia da COVID-19. Estudo de delineamento transversal, realizado na região do Triângulo Mineiro, estado de Minas Gerais, Brasil. Utilizou-se a Escala Spence de Ansiedade Infantil, versão para os pais, para avaliar os sintomas das principais perturbações de ansiedade em crianças. Para comparar proporções utilizou-se o teste Qui-quadrado, os fatores associados ao transtorno de ansiedade foram encontrados por Regressão de Poisson, com intervalo de confiança de 95%.  Participaram n=778 pais de crianças de três a 10 anos de idade. A prevalência do transtorno de ansiedade nas crianças foi de 1,7%. Crianças de pais analfabetos e com ensino fundamental II incompleto apresentaram razão de prevalência (RP) = 4,24 [(IC95%: 1,03 – 17,46), p=0,045] maior de transtorno de ansiedade que às crianças de pais com nível superior completo a pós-graduação, enquanto as crianças de pais com ensino fundamental a superior incompleto apresentaram uma RP = 2,64 [(IC95%: 0,72 – 9,72), p=0,045] em comparação às crianças de pais com nível superior completo a pós-graduação. Crianças com alterações nos padrões alimentares apresentaram uma RP = 11,10 [(IC95%: 1,59 – 77,42), p = 0,015] maior de transtorno de ansiedade, em relação às crianças que não possuíam alterações nos padrões alimentares. Concluiu-se que as variáveis que associaram ao transtorno de ansiedade foram o nível de escolaridade dos pais e alterações dos padrões alimentares das crianças.
MENGGALI POTENSI EKONOMI PENGEMBANGAN TANAMAN SACHA INCHI
Authors: Andayani Sri Ayu , Wijaya Acep Atma , Prasetyo Tri Ferga , Sukmasari Miftah Dieni , Umyati Sri , Sofyan Hadiyan Nur , Wahono Syiffa Safiera , Fernanda Billy Adrian , Purwanto Muhamad Dendi , Imanulyaqin Taufik , Isyanto Agus Yuniawan , Amalia Lidya Nur
Published: September 2023

Tanaman sacha inchi berpotensi dikembangkan secara ekonomi dengan melihat berbagai peluang manfaat bagi kesehatan, sector industry makanan, dan farmasi. Namun bukan karena belum begitu marak dibudidayakannya tanaman ini tetapi masyarakat masih belum memahami peluang-peluang komersial dan manfaat serta peluang produk turunan dari tanaman ini. Tema dari kegiatan pengabdian yaitu menggali potensi ekonomi dari pengembangan tanaman sacha inchi. Peningkatan pengetahuan, pemahaman dari potensi ekonomi tanaman sacha inchi dengan berbagai produk turunannya merupakan maksud dari kegiatan pengabdian ini. Metode dalam kegiatan pengabdian dengan menggunakan pendekatan edukasi, ceramah, penyuluhan melalui focus group discussion yang interaktif. Hasil akhir dari kegiatan ini para peserta berperan aktif dalam kegiatan melalui diskusi interaktif dan diperolehnya pengetahuan dan pemahaman yang lebih dari sebelum dilakukan kegiatan ini.
PENINGKATAN KETERAMPILAN MEMANFAATKAN BITTERN MENJADI TAHU SEHAT DI KOPERASI MEKARSARI SEJAHTERA, KABUPATEN BREBES
Authors: Setiawati Indah , Kusnaman Djeimy , Prasetyo Teguh Jati
Published: September 2023

Koperasi Mekarsari Sejahtera merupakan badan usaha yang berjalan dalam bidang produksi garam yang berada di Desa Kaliwlingi, Kecamatan Brebes, Kabupaten Brebes. Koperasi ini hanya baru dapat memproduksi garam rebus dan garam kelor. Dalam produksi garam rebus akan menghasilkan hasil samping berupa cairan kuning kecoklatan yang biasa disebut bittern. Namun, bittern masih belum dimanfaatkan oleh para petani dan akan dibuang pada setiap akhir produksi garam rebus karena para petani garam rebus masih kurang keterampilan dalam pengolahannya. Bittern memiliki banyak manfaat dalam kesehatan dan dapat menjadi bahan koagulan. Bahan ini dibutuhkan dalam pembuatan tahu untuk menggumpalkan sari kedelai yang biasanya menggunakan bahan cuka.   Berdasarkan data tersebut, diperlukan peningkatan keterampilan pemanfaatan limbah bittern oleh petani garam agar dapat menjadi inovasi produk turunan garam yang cocok pada semua kalangan, seperti makanan tahu. Kegiatan ini bertujuan untuk meningkatkan keterampilan para petani garam rebus Koperasi Mekarsai Sejahtera dalam pemanfaatan limbah bittern menjadi bahan koagulan pada tahu sebagai inovasi produk turunan dari garam rebus.  Kegiatan ini dilakukan dengan metode metode kegiatan difusi iptek dimana metode pelaksanaan kegiatan berupa pelatihan dan demonstrasi atau percontohan. Hasil akhir dari kegiatan ini petani garam rebus memiliki keterampilan dalam memanfaatkan limbah bittern menjadi sebuah produk tahu yang memiliki peluang jual yang tinggi.
Post-treatment PET/CT for p16-positive oropharynx cancer treated with definitive proton therapy
Authors: Alexander Gregory S. , Pollock Ariel Eve , Arons Danielle , Ferris Matthew J. , Molitoris Jason K. , Regine William F. , Witek Matthew E.
Published: September 2023

Objectives:

Given emerging data suggesting that uncertainty in the relative biologic effectiveness at the distal end of the Bragg peak results in increased mucosal injury in patients with oropharynx cancer receiving adjuvant proton therapy, we evaluated the results of post-treatment positron emission tomography–computed tomography (PET/CT) in patients with p16-positive oropharynx cancer (p16+OPC) treated with definitive intensity-modulated proton therapy (IMPT).

Material and Methods:

A retrospective cohort study of patients with p16+OPC treated with definitive IMPT between 2016 and 2022 was performed at a single institution. Patients with PET/CT scans within 6 months following completion of IMPT were included in the study. Positive post-treatment scans were defined by a maximum standard uptake values (SUVmax) >4.0 or a <65% reduction in SUVmax in either the primary tumor or lymph node. The Fisher’s exact test was used to evaluate factors associated with positive post-treatment PET/ CT values.

Results:

Sixty-two patients were included for analysis. Median follow-up was 21 months (range: 3–71 months) with a median time to post-treatment PET/CT of 3 months (range: 2–6 months). Median post-treatment SUVmax of the primary disease and nodal disease was 0 (mean: 0.8, range: 0–7.7) and 0 (mean: 0.7, range: 0–9.5), respectively. Median post-treatment percent reduction in SUVmax for the primary site and lymph node was 100% (mean: 94%, range: 31.3–100%) and 100% (mean: 89%, range: 23–100%), respectively. Eleven patients had a positive post-treatment PET/CT with one biopsy-proven recurrence. Negative and positive predictive values (NPV and PPV) were 98% and 9.1%, respectively. There were no factors associated with positive post-treatment PET/CT.

Conclusion:

Similar to patients treated with photon-based radiation therapy, post-treatment PET/CT has a high NPV for patients with p16+OPC treated with definitive proton therapy and should be used to guide patient management. Additional patients and more events are needed to confirm the PPV of a post-treatment PET/CT in this favorable patient cohort.
Economic Impacts of Platform-Endorsed Quality Certification: Evidence from Airbnb
Authors: Dewan Sanjeev , Kim Jooho , Nian Tingting
Published: September 2023

We contribute to the emerging literature on quality certification by digital platforms by studying the launch of the Airbnb Plus service, wherein the platform inspects properties and provides a badge that presumably signals the quality of the property and the reliability of the host. Our identification strategy relies on the fact that the Airbnb Plus service was launched in different cities at different times, and listings within the cities received the certification at different times. Using a staggered difference-in-differences estimation strategy in conjunction with suitable matching methods, we found that the Airbnb Plus certification increased the weekly booking rate of Plus listings by about 6.8% on average (direct effect). We also found some evidence that non-Plus listings saw a temporary decline in booking rate when one or more nearby properties received a Plus certification (externality effect). The net impact of the Airbnb Plus service on the platform itself was an annual increase in revenue of about $37,500 for the average 2-kilometer zone in a U.S. city that included one or more Plus listings, as compared to matched zones without any Plus listings (local platform effect). We performed additional analyses, including a randomized experiment, to demonstrate the robustness of our findings. Overall, our results suggest that platform-endorsed quality certification has significant economic impacts—not just on the listings that receive the certification but on other listings on the platform as well as on the platform itself.