bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of the potential of the financial market of the Krasnodar Territory in the context of financial service providers
Authors: Korolyuk Elena Vladislavovna , Mezentseva Ekaterina Viktorovna
Published: October 2022

The purpose of the study is to identify the contours of the potential of the financial services market in the Krasnodar Territory in the context of suppliers in order to determine the vector of further market development. The article examines the dynamics of organizations engaged in financial and insurance activities, assesses the institutional provision of the banking services market, represented by the number of insurance entities in dynamics in recent years, analyzes the volume of insurance fees and payments, analyzes the number of organizations and the volume of the microfinance market. Scientific novelty lies in unlocking the potential of the financial services market in the Krasnodar Territory. As a result, the key problems and growth vectors of the studied market were identified as a strategic imperative for the socio-economic development of the territory.
Economic security in Russia: current state, threats and prospects of development
Authors: Lopasteyskaya Lyudmila Gennadyevna
Published: October 2022

The purpose of the study is to determine the current state, threats and prospects for the development of Russia's economic security. The scientific novelty lies in the development of key areas for countering threats to Russia's economic security, which are represented by the consequences of the impact of the COVID-19 coronavirus infection. The solution to the key problems that have arisen as a result of the pandemic is to ensure effective protection of the Russian economy. Accordingly, the key direction of public administration should be the solution of strategic issues to stimulate the activity of small and medium-sized businesses, as well as to increase investment flows. As a result, the key risks and threats affecting the economic security of the Russian Federation were identified. In addition, the key problems affecting the level of economic security of the country are identified, which determines the relevance of studying the features of ensuring economic security in the country. In conclusion, recommendations aimed at improving the current system of economic security at the country level are proposed.
Rural and Urban EMS Level of Comfort with Overdose Treatment
Authors: Ratcliffe Brycen , Danek Robin , Ireland Ellen , Reyes Eric
Published: October 2022

Purpose: This study aims to determine aptitude levels of rural and urban EMS providers treating drug overdoses in the field.
Methods: This is both a qualitative and quantitative cross-sectional survey including 90 respondents from urban and rural demographics.
Findings: This study found no evidence (p = 0.126) that the likelihood of being extremely comfortable with administering Naloxone differed between urban and rural EMS workers when accounting for certification level, years of experience and amount of training. We also found no evidence (p = 0.859) of a difference between rural and urban EMS workers administering secondary doses of naloxone.
Conclusion: This study demonstrated that although rural EMS providers have an increased transit time to get an overdose patient to the hospital and were less likely to have an advanced provider available to them at the response scene, rural providers feel similarly comfortable with treating an opioid overdose with naloxone as their urban counterparts when certification level, years of experience and number of hours of training are considered.
Black Seed Dreaming: A Material Analysis of Bruce Pascoe’s “Dark Emu”
Authors: Glowczewski Barbara , Lundberg (Trans.) Anita
Published: October 2022

Indigenous Australians are outstanding for the way their ontologies and practices do not rely on a Western dichotomy that opposes material and spiritual realms. Their multiple totemic visions of the Dreaming space-time always state a material actualisation in landscape and the reproduction of all forms of life based on the pluriversal agency of animals, plants, minerals, rain, wind, fire and stars. Such cosmovisions resonate with current debates in the fields of critical posthumanism and new materialism through an Animist materialism. Indeed, Indigenous Australian’s complex social practices offer ways of thinking and being for the whole planet in this time of climate crisis. This is particularly crucial for the tropical world which is so strongly impacted by climate change. Indigenous Australian cosmovisions offer to tropical studies a way of thinking politically about climate and the materiality of life. Thus, Tropical Materialisms are enhanced by the vast body of Indigenous experiences and creative productions in and beyond the tropics. The material analysis of the Aboriginal author Bruce Pascoe’s Dark Emu, demonstrates how the book dared to challenge the Western written history, and to show a new relationality of being of humans with the more-than-human world.
ANALISIS MOTIVASI BELAJAR MATEMATIKA SISWA MAN 1 KOTA CIREBON PADA PEMBELAJARAN DARING DIMASA PANDEMI COVID-19
Authors: Azizah Azizah , Rustika Putik , Lusiyana Desy
Published: October 2022

This study aims to determine the students' motivation to learn mathematics in online learning during the covid-19 pandemic at MAN 1 Cirebon City in class XI. This type of research is a field research with a descriptive qualitative approach. Methods of data collection is done by observation, questionnaires, interviews and documentation. Researchers took high school students at MAN 1 Cirebon City class XI as a sample, data source sample collection was done purposively and snowball to produce a sample that can logically be considered representative of the population and find key informants who have a lot of information. The results of the study stated that the mathematics learning motivation of MAN 1 Cirebon City students during the covid-19 pandemic was in the "moderate" category with the average percentage gain from the observational analysis of learning motivation of 56.25%, while the results of the questionnaire analysis of learning motivation obtained an average percentage by 78.42% so that it is included in the "high" category. Based the results of interviews and questionnaires, can be concluded that students of MAN 1 Cirebon City have high motivation. So, the motivation for learning mathematics at MAN 1 Cirebon City students in online learning during the COVID-19 pandemic is categorized as "high" from the results of interviews where students meet six indicators of learning motivation.
ANALISIS KEMAMPUAN BERPIKIR KREATIF MATEMATIS SISWA SMP PADA MATERI BANGUN DATAR
Authors: Kamalia Nur Azizah , Ruli Redo Martila
Published: October 2022

This study aims to describe the mathematical creative thinking ability of class VIII junior high school students in one of the schools in Karawang district in solving problems related to the material of flat shapes. This study uses a qualitative approach with a descriptive method. The subjects in this study were 16 students of class VIII in one of the junior high schools in Karawang Regency. The instrument used was in the form of a mathematical creative thinking ability test consisting of four essay questions and interview guidelines.  The data collection techniques used in this research were tests and interviews. The data analysis technique used in this study consisted of data reduction, data presentation, and conclusion drawing. Based on the results and discussion of this study, it shows that the test results of students creative thinking skills are 25% in the high category with 4 students, 31.25% in the medium category with 5 students, and 43.75% in the low category. with a total of 7 students. So it can be concluded that the mathematical creative thinking ability of SMP class VIII students at one of the schools in Karawang district is still relatively low, and students also have not met the indicators of creative thinking skills, namely fluency, flexibility, originality, and elaboration
HUBUNGAN SELF EFFICACY DENGAN KEMAMPUAN KOMUNIKASI MATEMATIS SISWA KELAS VIID MTSN 13 PESISIR SELATAN
Authors: Yessa Ridha Ulfahmi , Rahmi Rahmi , Delyana Hafizah
Published: October 2022

Mathematical communication is a high level skill that students have acquired. Students' self efficacy is required to boost their learning confidence. The goal of this study was to see if there was a link between self efficacy and mathematical communication skills in Pesisir Selatan’s class VII D MTsN 13. This type of research is quantitative which is classified as correlational. The subjects of this study were 26 students were selected purposive sampling. A self efficacy test and a mathematical communication test were utilized to collect data in this study. This study’s data analysis method includes a simple linear regression test, a correlation test, and a hypothesis test utilizing the t test. Based the analysis it’s indicating that the linear relationship between X and Y is weak, and the analysis concluded that there is a weak but not significant relationship between self efficacy students’ mathematical communication skills in class VII D MTsN 13 Pesisir Selatan. After being traced through interviews, it was found that students were weak in understanding concepts, this was indicated by some students still confused with the use the right concepts in solving the problem given.
PENERAPAN VECTOR AUTOREGRESSIVE (VAR) DALAM MEMPREDIKSI RETURN SAHAM DI INDONESIA
Authors: Miasary Seftina Diyah
Published: October 2022

The rate of return (return) and risk are inseparable in investing activities. One equilibrium model that describes the relationship between return and risk assumes that the expected return is influenced by more than one macroeconomic factor. Furthermore, the causal relationship between stock returns and macroeconomic factor returns was analyzed using VAR. The application of VAR in this study is to predict stock returns through the stages of checking data stationarity, determining the optimal lag length, testing Granger causality between variables, estimating VAR model parameters and Portmanteau diagnostic tests, and predicting stock returns. The results show that the VAR (1) model is the most appropriate model to describe the relationship between stock returns and macroeconomic factor returns with a significant model owned by BBCA, ICBP, INTP, KLBF, and SMGR stocks. Furthermore, the VAR (1) model is used to predict the five stock returns. The prediction results show that INTP's stock returns are negative while the returns of the other four stocks are positive. This shows that INTP shares experienced a capital loss, while the stock returns of BBCA, ICBP, KLBF, and SMGR experienced capital gains
Prevalência de traumatismo dentário e suas sequelas em pacientes atendidos em duas clínicas escola de odontologia do estado de Alagoas
Authors: Oliveira Nayr Karlla Alves de , Sampaio Mariana Camerino , Santos Hayara Ohana Lima , Oliveira Diego Mauricio de , Gama Luana Peixoto , Lins Filho Gastão Tenório , Sarmento Bárbara Tenório , Nóbrega Diego Figueiredo , Inojosa Inês de Fátima de Azevedo Jacinto , Lins Fernanda Freitas
Published: October 2022

Objetivo: Avaliar a prevalência de traumatismos dentários em pacientes atendidos em extensões de Trauma Dental de dois Centros Universitários no estado de Alagoas, um público e o outro privado. Métodos: Realizou-se um estudo observacional transversal a partir de prontuários, desde 2012, das clínicas escola de Odontologia das universidades, privada e federal do estado de alagoas presente na capital, excluindo pacientes menores de 6 anos e/ou traumas em dentes decíduos. Efetuou-se análise estatística utilizando técnicas de Estatística Descritiva como cálculo de desvios padrões e distribuição de frequências. Resultados: Número total de pacientes foi 95, sendo os homens (67,4%) mais acometidos. Incisivo central superior é o dente de maior incidência (71,4%), a etiologia de maior ocorrência foi a queda da própria altura (53,7%), fraturas de esmalte, dentina (33,1%) e avulsão (9%) são estruturas de suporte mais afetadas. O tratamento de necropulpectomia (27,9%) foi o mais frequente nesta pesquisa. Conclusão: O conhecimento das populações de risco e tipos de traumas existentes é imprescindível para criar campanhas de prevenção e informar como agir nestes casos.
Autoestima de mães universitárias no ambiente acadêmico
Authors: Maciel Victória de Quadros Severo , Sehnem Graciela Dutra , Kegler Jaquiele Jaciara , Siqueira Fernanda Duarte , Cogo Silvana Bastos , Almeida Denise Comin Silva , Mello Giovana Batistella de , Medeiros Leandro da Silva de , Martelli Gicelle Moraes , Beltrame Giana da Rosa
Published: October 2022

Objetivo: Identificar o nível de autoestima das mães universitárias dos cursos de graduação de uma Instituição de Ensino Superior do interior do estado do Rio Grande do Sul. Métodos: Pesquisa quantitativa, desenvolvida com 31 estudantes de graduação que possuíam filhos de até dois anos de idade, realizada em uma Instituição de Ensino Superior. A coleta de dados ocorreu por meio de aplicação de questionário de caracterização e da Escala de Autoestima de Rosenberg. Os dados foram organizados no programa Epi-info® (versão 7.2.3). A análise ocorreu por meio de estatística descritiva no programa estatístico R. Resultados: A maioria das mães universitárias eram brancas, na faixa etária dos 20 aos 29 anos, possuía companheiro e um filho. Nos resultados acadêmicos, 22 nunca trancaram o curso e 28 não receberam nenhum tipo de assistência estudantil. Essas mulheres não participavam de atividades de ensino, pesquisa e extensão. Em relação à autoestima, 21 mães universitárias possuem uma autoestima moderada. Conclusão: Concluiu-se que as mães universitárias enfrentam duros desafios para conciliar estudos e demandas maternas, gerando estresse, autoestima baixa, falta de ânimo para conclusão do curso.
Ruptured aneurysm associated with a twig-like middle cerebral artery: An illustrative case report
Authors: Serrano-Rubio Alejandro , Ferrufino-Mejia Bill Roy , Balcázar-Padrón Juan C. , Rodríguez-Rubio Héctor A. , Nathal Edgar
Published: October 2022

Background:

Anomalies of the middle cerebral artery (MCA) are rare; among the different types of anomalies, the aplastic or twig-like (Ap/T) MCA is extremely rare and has been reported under various names, including aplastic, unfused, or rete type anomaly. The occurrence of a brain aneurysm associated with this anatomic variant is an even rare event, and probably their development and rupture are related to hemodynamic stress of the tinny wall of vessels forming the network.

Case Description:

We present a 43-year-old male patient with an explosive and persistent right orbitofrontal headache. A computed tomography showed a right frontobasal hematoma with intraventricular disruption. Magnetic resonance angiography showed a right MCA aneurysm and what seems to be a MCA trunk stenosis. Cerebral digital subtraction angiography demonstrated a plexiform arterial network and one aneurysm arising from the network. The patient was successfully treated by surgical clipping to evacuate the hematoma and to prevent further intracranial hemorrhages.

Conclusion:

The Ap/T-MCA may be associated with hemodynamic stress with a significant effect through the tinny wall of the vessels causing hemorrhage or leading to the formation and rupture of cerebral aneurysms. Based on a correct diagnosis of the anomaly, treatment can be completed successfully through different standard methods.
Modified anterior transarticular C1/2 fixation for odontoid fractures: An approach with high complication rate in geriatric population
Authors: Mourad Mohammed Ahmed , Ottenbacher Andy , Rizk Ahmed R.
Published: October 2022

Background:

In patients over 75 years of age, we applied a modified anterior transarticular C1/2 fixation with reduced pharyngeal mobilization versus the standard anterior triple/quadruple osteosynthesis procedures.

Methods:

From 2010 to 2018, 29 patients underwent a modified anterior transarticular C1/2 fixation utilizing single odontoid screw fixation through a right-sided Smith-Robinson – (i.e., short and steep screw trajectory for the right and long trajectory for the left side) approach. All the patients were 75 years of age or older (mean age 82.6) and had sustained odontoid Type II fractures. In addition, a subset exhibited further ligamentous injuries and/or atlas fractures. Their Mean Age-adjusted Charlson Comorbidity Index was 5.3 points (range 3–12), while mean American Society of Anesthesiologists scores averaged 2.9 (range 2–4).

Results:

The mean operating time was 55.8 min, there were no intraoperative complications, and there was minimal blood loss in all cases. The most common medical complications included aspiration pneumonia (24.1%, n = 7), altered mental status (17.2%, n = 5), and cardiac decompensation (6.9%, n = 2). One patient with delayed dysphagia and an infected implant resulting in loosening/dislocation required implant removal and long-term antibiotic therapy. The 30-day mortality rate was 13.8% (four patients) and the 1-year mortality rate was 27.6% (eight patients).

Conclusion:

Anterior transarticular C1/2/odontoid fixation with reduced pharyngeal mobilization and shorter operative times was associated with high morbidity/mortality rates. Dysphagia/aspiration was the major postoperative complications leading to some deaths especially in patients with dementia/Parkinsonism.
The development of a new, ultra-fine, and flexible neuroendoscope for intracranial observation
Authors: Onoda Keisuke , Sashida Ryohei , Hirokawa Yu , Fujiwara Ren , Wakamiya Tomihiro , Michiwaki Yuhei , Tanaka Tatsuya , Shimoji Kazuaki , Suehiro Eiichi , Yamane Fumitaka , Kawashima Masatou , Matsuno Akira
Published: October 2022

Background:

A neuroendoscope is a technical advance that allows surgeons to visualize certain regions of the brain that was previously inaccessible through the use of a surgical microscope. Several neuroendoscope designs have been implemented by other neurosurgeons over the past 5 years. The advantage of a neuroendoscope is the addition of a flexible and narrow tip that allows for safe entry into intracranial structures for clinical observation. However, there are some limitations to this approach. Here, we report the use of a modified angioscope as a newly developed neuroendoscope to be employed in observing intracranial structures.

Methods:

We report the use of an angioscope that is 1.8 mm in diameter and has both a thin and flexible tip. In this study, the angioscope was inserted into the lumen of an aspirator tube, and the tip of the device was placed at the intracranial area of intended observation area. Image findings were evaluated using an established in vivo goat brain model.

Results:

The angioscope was light in weight and maneuverable and could be reached and observed in the blind spot using a surgical microscope. From the cerebellopontine angle, the lower cranial nerves and trigeminal nerve could be observed, and from the cisterna magna, the floor of the fourth ventricle and the aqueduct could be seen.

Conclusion:

The angioscope is a useful instrument to observe intracranial locations safely and effectively even within a limited surgical field. Further modifications will be required to use the angioscope in various craniotomy procedures.
Synthesis, Antioxidant ability and Docking study for new 4,4'-((2-(Aryl)-1H-benzo[d]imidazole-1,3(2H)-diyl)bis(methylene))diphenol)
Authors: Raied Mustafa Shakir , Shaimaa Abed Saoud , Dhuha Faruk Hussain , Khalid Fahad Ali , Firas Shawqi Algburi , Husam Salman Jasim
Published: October 2022

New series of 4,4'-((2-(Aryl)-1H-benzo[d]imidazole-1,3(2H)-diyl)bis(methylene))Diphenol(3a-g) was successfully synthesized from cyclization of the reduction product of bis Schiff bases (2) with aryl aldehydes bearing phenolic hydroxyl in the presence of acetic acid. The structure of these compounds was identified from FT-IR, 1H NMR, 13C NMR and EIMs. The Antioxidant capability was screened by DPPH and FRAP assays. Both assays showed antioxidant capability more than BHT as well. Compounds 3b and 3c showed antioxidant capacity slightly less than ascorbic acid. The docking study for theses compound was carried out as III DNA polymerase inhibitor. The results of docking demonstrated that the increase in hinderances around phenolic hydroxyl for the aryl attached position two for benzimidazole decrease the capability of interaction and give less bending and smaller docking score and there is inverse relationship between increasing hindrances around phenolic hydroxyl and DNA polymerase inhibition for these compounds.
Cluster Fig (Ficus racemosa Linn): A sustainable renewable source for Bioethanol Production by Fermentation
Authors: Kedar P.G. , Wagh S.T. , Konale R.A. , Patil N.K. , Ingle S.T.
Published: October 2022

Increased demand and remarkable rise in prices of petroleum products have resulted in the need to discover alternative energy resources to satisfy the energy demand of the world. Bioethanol has been recognized as the most used biofuel globally since it is known to contribute in the reduction in crude oil consumption and global environmental pollution. Bioethanol can be produced from feedstock such as starch, sucrose, lignocellulosic and algal biomass through the fermentation process by microbes. Hence, the main objective is to satisfy this requirement leading to the development of easier methods using inexpensive and eco-friendly raw materials for the bioethanol production. In the present investigations, production of bioethanol from Ficus racemosa L. (Cluster fig), using active Saccharomyces cerevisiae (baker's yeast) strain was examined. The organolepsis, miscibility, boiling point, pH, specific gravity, combustion test, tri-iodomethane test and the reducing sugar of Ficus racemosa fruits were determined. Parameters such as pH, temperature, fermentation period, yeast concentration and yeast supplements were optimized for ethanol production. Bioethanol was obtained by double distillation process after the fermentation reaction of fruits. The results show that the maximum rate of ethanol production through fermentation of Ficus racemosa fruit waste by Saccharomyces cerevisiae increases with the fermentation period and yeast concentration at 30°C in 120hrs.
Study on existence of Pesticides in Indian Grapes and their Compliance for Export to EU Nations through Advanced Analytical Instrumentation
Authors: Pasupuleti Venkata Vidyasagar , Majji Kiranmai Reddy , Bagade Prashant , Kachireddy Venkata Naga Suresh Reddy
Published: October 2022

India is one of the leading exporters of grapes to the international market. Maharashtra leads the country in production, accounting for about 81.22 percent of total output and the highest productivity. It is exporting an increasing amount of its products to European countries. Farmers use lot of pesticides to grow grapes economically and get a higher yield. As a result, it is critical to ensure that such pesticide residues do not end up in food at levels that pose an unacceptable risk to humans. To mitigate such risk, the European Commission has established maximum residue limits (MRLs) to safeguard consumers against the deleterious effects of pesticide residues in food. This study aimed to determine how well grapes adhered to the European Commission's guidelines during the 2017-20 seasons. During 2017-20, 208 pesticides were tested in each of the 4861 grape samples using LC-MS/MS and GC-MS/MS devices. According to the findings, during the three seasons, 8.1 percent to 13.8 percent of grape samples were contaminated with pesticides above the MRL. It suggests that either the preharvest interval was not followed for plucking grapes or pesticides were applied at a dose that is higher than recommended. Chlorpyrifos, buprofezin, 4-bromo-2-chlorophenol, nitenpyram 4-Chloro-3-methyl phenol, abamectin and forchlorfenuron (CPPU) are the pesticides that were found in most of the samples.
Synthesis and Characterization of Indole Azo Metal Complexes and Study of their Biological Activity
Authors: Youssef Ghufran Shakir , Mohammed Hasan Shamran
Published: October 2022

Novel azo dye ligand APAI namely 3-(4-(antipyrinyl)azo)-indole was synthesized by the coupling of diazonium salt of 4-aminoantipyrine and indole compound in basic conditions. Co(II) and Zn(II) complexes were synthesized in 1:2 molar ratio of metal ion to ligand. The structure of the APAI ligand and the metal complexes was established using 1H-NMR, IR, mass spectrometry, UV-Vis, powdered XRD, molar conductivity and magnetic susceptibility. The APAI ligand exhibited significant photochromic characteristics as well as high acidity sensing capability. The infrared data indicated that APAI dye behaves as bidentate ligand. The spectral studies indicated to octahedral geometry for Co(II) and Zn(II) complexes. The cytotoxicity impact of APAI ligand and zinc complex was screened against the MCF-7 cell line (human breast cancer) and health cells of HdFn. The MTT results indicated that APAI ligand and zinc complex induce high cytotoxicity potential against MCF-7 cells with low toxicity against healthy cells of HdFn. The APAI ligand induces higher cytotoxicity potential against MCF-7 cells as compared to zinc complex.
A highly sensitive and selective method for the development and validation of potential genotoxic impurity in Raltegravir by high-throughput UPLC-MS/MS
Authors: Annapoorna Vadlamani , Ravindhranath K. , Sreenivasa Rao B.
Published: October 2022

Raltegravir is a human immunodeficiency virus (HIV) integrase inhibitor, a novel anti-AIDS drug. To quantify genotoxic impurities (GTIs), conventional analysis techniques are inadequate as a result, there is a high need to develop critical analytical methods for drug analysis using the hyphenated analytical technique. A highly sensitive and selective method was developed and validated for the estimation of genotoxic impurity in Raltegravir Active pharmaceutical ingredient (API) by using UPLC-MS/MS. The UPLC-MS/MS analysis for the quantification of GTI was performed on the symmetry C18 (150 mm×4.6 mm,3.5μm) analysis column and separation of genotoxic impurity was achieved under a gradient mode system using a mobile phase comprising 1% acetic acid as mobile phase (A) and acetonitrile as mobile phase (B) with a column temperature of 40°C and flow rate of 0.5 mL/min. A triple mass quadrupole detector was used to measure GTI by combining with the negative-electrospray ionization used in multi-response monitoring mode (MRM). The newly developed method was validated as per ICH guidelines and was able to measure GTI at 2.0 ppm for about 10mg/mL solution of Raltegravir. The %RSD obtained for GTI for six preparations was 1.74 in method precision and 2.56 during the variation of analyst, system and column on a different day. The overall %RSD of 2.73 showed the ruggedness of the method. The GTI is linear from 0.039 to 2.9ppm (LOQ to 150%) and R= 0.9998 showed good linearity. The % recovery obtained for genotoxic impurity was in the range 103.0-109.6% with %RSD 1.51-3.19 from 0.42 to 2.5ppm. The %RSD in precision and accuracy at LOQ is 1.63 and 3.19 indicating the sensitivity of the method. The newly proposed and developed high-sensitive method can be used to detect GTI in Raltegravir API and formulation.
Hydrogen-bonded helix formation by N-brigded tripodal ligand
Authors: Kaur Sarvjeet , Batra Meenal , . Shruti , Mann Suruchi , . Kamaldeep , Singh Ashutosh S.
Published: October 2022

Hydrogen-bonded helix formation by a simple N-bridged tripodal ligand is reported. The ligand has been synthesized by reduction of product formed through substitution reaction of tris(2-chloroethyl) amine hydrochloride by hydroxybenzaldehyde. The reported ligand has been characterized by 1H NMR, 13C NMR, IR and mass spectra. Crystal structure has been characterized by single crystal X-ray diffraction and thermogravimetric analysis.
Green synthesis and antimicrobial activity of 1,3-diaryl pyrazole based chalcone derivatives
Authors: Guguloth Ravi , Anjaneyulu K. , Mekala Himabindu , Sridhar Midde
Published: October 2022

We report a facile green synthetic protocol for the synthesis of 1,3-diaryl pyrazole based chalcone derivatives by the condensation of 3-Aryl-1-phenyl-1Hpyrazole- 4-carbaldehydes with arylmethylketones in the presence of base in both microwave and ultrasound irradiation method. The synthesized compounds were evaluated for in vitro antimicrobial activity against four bacterial organisms and two fungal organisms showing moderate to good activity.
Antituberculosis activity of pyrazoles
Authors: Vashisht Ketan , Sethi Pooja , Mishra Purti , Bansal Anshul
Published: October 2022

Heterocyclic compounds containing nitrogen and their derivatives have been reported historically as ingenious therapeutic agents. Pyrazole is one of foremost class of heterocyclic compounds which are abundantly reported across the literature. Various reports suggested that compounds containing pyrazole scaffold possess diversified and novel pharmacological profiles. Recently, researchers have focused on the analysis, significance and medical attributes of compounds having pyrazole moiety. Literature showed that there has been a great deal of interest in developing new compounds with antituberculosis activity. In this review, authors have tried to examine recent published literature based on derivative of pyrazole and special emphasis on their antituberculosis activity explored from 2015 to 2020.
Ecological and economical value of Artemisia spp. and tarragon cultivation under dry climate of Kalmykia
Authors: Джиргалова Е. , Бадмахалгаев А. , Ниджляева И. , Оросов С. , Эрднеева Б.
Published: October 2022

Исследования проводились в 1990–2007 годах в сухостепной и полупустынной зонах Северо-Западного Прикаспия. Для этих зон впервые получено экспериментальное обоснование использования разных видов полыни в качестве кормовых культур, разработана технология возделывания эстрагона кормового, дана рекомендация по подготовке посадочного материала, приёмам основной обработки почвы, срокам и способам посадки и улучшению водного режима травостоя данной культуры путём применения полиакриламида (гидрогеля), обеспечивающих получение 2,5–3,0 т/га абсолютно сухого вещества при минимально возможных затратах труда и средств, наиболее полное использование агроклиматических ресурсов и получение пастбищного корма для осеннего и зимнего использования, проведена оценка продуктивности, питательной ценности полыни эстрагонной в зависимости от технологических приёмов возделывания и года жизни травостоя. В проведённых исследованиях получены положительные результаты, играющие важную роль в обеспечении животных пастбищными кормами, особенно в зимнее время, из которых наиболее ценными являются полыни белая, чёрная, солончаковая и эстрагонная. Эффективным способом выращивания эстрагона является его размножение черенками диаметром 1,0 см, имеющими две-три почки и обработанными перед посадкойкой БАВ «Дипрол» (50 г/л) с экспозицией 2 ч. Сорт полыни эстрагонной Нарн характеризуется высокой засухо- и жаростойкостью, продолжительностью произрастания, эффективно использует тепловые и водные ресурсы, обеспечивая высокую урожайность зелёной массы (3,81 т/га) с содержанием 1,57 т абсолютно сухого вещества, 14,4 ГДж обменной энергии и 164 кг сырого протеина.

Investigations took place in 1990–2007 in dry-steppe and semidesert of the north-western Caspian Sea region. Artemisia spp. were tested for forage production; A. absinthium, A. pauciflora, A. halodendron and A. dracunculus being of the highest value. For the first time research crew developed tarragon cultivation technology for these zones as well as recommendations on planting material, methods of primary tillage, seeding time and techniques. Polyacrylamide (hydrogel) improved tarragon water regime and provided 2.5–3.0 t ha-1 of absolute dry matter under minimum costs. Tarragon productivity and nutritional value were evaluated as influenced by cultivation techniques and plant life cycle. Positive results obtained played an important role in field forage production, particularly for the winter period. Propagation by cuttings is widely used in tarragon cultivation. Cuttings treated by “Diprol” (biologically active substance) for 2 hours before seeding had diameters of 1.0 cm and two-three buds. Tarragon “Narn” had high drought-resistance and long growing season. It used effectively warmth and water resources producing high yield of green mass (3.81 t ha-1) that contained 1.57 t of absolute dry matter, 14.4 GJ of exchange energy and 164 kg of crude protein.
DAMPAK PANDEMI COVID 19 TERHADAP PROSES PEMBELAJARAN PADA PESERTA DIDIK SMA BINA UTAMA
Authors: Arjunanata Vito , Kardi Kardi , Pratama Hendi , Kurniawan Syafarani
Published: October 2022

Pembelajaran pada hakikatnya adalah suatu proses, yaitu proses mengatur, mengorganisasi lingkungan yang ada di sekitar peserta didik sehingga dapat menumbuhkan dan mendorong peserta didik melakukan proses belajar.  Pembelajaran juga dikatakan sebagai proses memberikan bimbingan atau bantuan kepada peserta didik dalam melakukan proses  belajar. Semenjak pandemi berlangsung membuat proses pembelajaran mengalami beberapa perubahan yang dimana biasanya tatap muka sekarang belajar dirumah. Setelah penurunan pandemic dikeluarkan kebijakan baru dalam pendidikan dari pemerintah yaitu memperbolehkan dilakukan proses pembelajaran tatap muka kembali.  Salah satu sekolah yang melakukan pembelajaran tatap muka yaitu SMA Bina Utama Pontianak,serta sekolah ini merupakan tempat penelitian kami.  Selain itu, jenis penelitian kami gunakan yaitu penelitian kualitatif yang dengan penelitian ini menggunakan teknik pengumpulan data yaitu dokumentasi,wawancara dan dokumentasi. Dari penelitian ini  kami bertujuan untuk mengetahui dampak proses perubahan yang dialami siswa selama daring dan luring terhadap pandemi,proses praktik pembelajaran daring ke luring serta dampak pembelajaran daring keluring terhadap pandemi covid.Kata kunci: Perubahan,Covid,Pembelajaran
PENGKAJIAN MUATAN MATERI TERKAIT GEOPOLITIK DALAM PEMBELAJARAN IPS DI TINGKAT SMA: APAKAH MASIH RELEVAN?
Authors: Susdarwono Endro Tri
Published: October 2022

Tujuan penelitian ini meneliti mengenai pengkajian muatan materi terkait Geopolitik dalam pembelajaran Ilmu Pengetahuan Sosial (IPS) di Tingkat SMA: Apakah Masih Relevan?. Metode penelitian yang diterapkan meliputi, pendekatan yang digunakan dalam penelitian merupakan kuantitatif, teknik pengumpulan data menggunakan survei dengan purposive sampling, sedangkan teknik analisis data menggunakan pengujian hipotesis atas tanda guna menganalisis dampak yang timbul karena terjadinya suatu hal dan Pengujian hipotesis Mac Nemar change test yang dilakukan guna memastikan ada atau tidaknya perubahan preferensi sebelum dan sesudah perlakuan. Hasil dari penelitian ini menyatakan berdasarkan pengujian hipotesis atas tanda didapatkan bahwa hasil perhitungan nilai khai-kuadrat adalah 8,82 dan nilai ini lebih besar daripada nilai khai-kuadrat dalam tabel sebesar 3,841. Sebagai implikasinya, sebaiknya materi terkait mengenai geopolitik tetap direkomendasikan untuk dimasukkan dalam muatan materi pembelajaran IPS di tingkat SMA. Berdasarkan pengujian hipotesis Mac Nemar change test diperoleh bahwa hasil perhitungan nilai khai-kuadrat sebesar 0,167 dan nilai tersebut lebih kecil daripada nilai khai kuadrat dalam tabel 3,841. Sehingga hipotesis nihil dinyatakan diterima, responden berpendapat bahwa kajian muatan materi terkait geopolitik masih relevan dimasukkan pada pelajaran IPS di tingkat SMA. Keterbatasan penelitian belum mencakup detail permasalahan terkait geopolitik, sedangkan kontribusi penelitian terkait dengan keberadaan pendidikan IPS harus dipahami bahwa setiap bangsa dalam rangka mempertahankan eksistensinya dan untuk mewujudkan cita-cita dan tujuan nasionalnya perlu memiliki pemahaman geopolitik.
Ligand-directed Photocatalysts and Far-red Light Enable Catalytic Bioorthogonal Uncaging inside Live Cells
Authors: Rosenberger Julia , Xie Yixin , Fang Yinzhi , Lyu Xinyi , Trout William , Dmitrenko Olga , Fox Joseph
Published: October 2022

Described are ligand-directed catalysts for live-cell, photocatalytic activation of bioorthogonal chemistry. Catalytic groups are localized via a tethered ligand either to DNA or to tubulin, and red-light (660 nm) photocatalysis is used to initiate a cascade of DHTz-oxidation, intramolecular Diels-Alder reaction, and elimination to release phenolic compounds. Silarhodamine (SiR) dyes, more conventionally used as biological fluorophores, serve as photocatalysts that have high cytocompatibility and produce minimal singlet oxygen. Commercially-available conjugates of Hoechst dye (SiR-H) and Taxol (SiR-T) are used to localize SiR to the nucleus and tubulin, respectively. Computation was used to assist the design of a new class of redox-activated photocage to release either phenol or n-CA4, a microtubule-destabilizing agent. In model studies, uncaging is complete within 5 min using only 2 µM of SiR and 40 µM of the photocage. In situ spectroscopic studies support a mechanism involving rapid intramolecular Diels-Alder reaction and a rate determining elimination step. In cellular studies, this uncaging process is successful at low concentration of both the photocage (25 nM) and the SiR-H dye (500 nM). Uncaging n-CA4 causes microtubule depolymerization and an accompanying reduction in cell area. Control studies demonstrate that SiR-H catalyzes uncaging inside the cell, and not in the extracellular environment. With SiR-T, the same dye serves as photocatalyst and the fluorescent reporter for tubulin depolymerization, and with confocal microscopy it was possible to visualize tubulin depolymerization in real time as the result of photocatalytic uncaging in live cells.
The Shape of Water – how cluster formation provides a unifying explanation of water’s anomalous properties
Authors: Andersson Martin
Published: October 2022

Water, essential to life on Earth, has many anomalous properties, that are not yet fully understood. We used computational chemistry to calculate the dynamic equilibrium of formation of water clusters in water. Clusters of certain shape are predicted to exist at ambient down to supercooled conditions and their presence almost quantitatively explains water’s anomalous properties as a function of temperature and pressure. The dodecahedron is the dominant cluster below ~240 K and below ~150 MPa and forms a miscibility gap with water below a critical point at ~225 K. The hexagonal torus is the dominant cluster above ~240 K and below ~75 MPa. Their presence explains the density maximum of pure water at 4 °C. Both the dodecahedron and the torus are low-density clusters and their tetrahedral water structure are consistent with spectroscopic data. At pressures above ~100 MPa, many of water’s anomalous properties diminish or vanish, which is also the pressure above which high-density water clusters become more stable and prevalent. Our simple unifying theory reproduces water’s anomalous properties from supercooled to ambient temperatures and from ambient pressure up to at least 400 MPa, including density anomalies, two-liquid behavior, compressibility and heat capacity.
Optical tactile sensor using scattering inside sol–gel-derived flexible macroporous monoliths
Authors: Hayase Gen
Published: October 2022

Tactile sensors are an essential technology for robots, and various types have been developed. This paper reports on a new optical tactile sensor based on multiple scattering in a porous material with a viscoelastic phase-separated structure fabricated by a sol–gel method. When a macroporous silicone monolith with a few micrometer diameter skeletons was compressed, the diffuse light intensity near the light source was reduced due to Mie multiple scattering. A simple tactile sensor using a macroporous monolith and a photo reflector was fabricated based on this finding. The skeleton diameter was an important factor for the sensor. In the case of macroporous silicones, the voltage-strain curve showed an almost hysteresis-free clear response. However, the response of macroporous polymethylmethacrylate monolith with a smaller skeleton diameter was weak due to low Mie scattering intensity. Using cell structure materials with a scale much larger than the optical wavelength, a decrease in light intensity with compression was not observed. Sensors using sol–gel-derived flexible macroporous monoliths could provide features such as thinness and improved surface tactility.
Iron-Catalyzed C(sp2)-C(sp3) Suzuki Cross-Coupling Using an Alkoxide Base
Authors: Peterson Paul O. , Joannou Matthew V. , Simmons Eric M. , Wisniewski Steven R. , Kim Junho , Chirik Paul J.
Published: October 2022

The synthesis and characterization of iron(II) alkyl precatalysts for C(sp2)–C(sp3) Suzuki-Miyaura cross-coupling of aryl boronic esters and alkyl bromides is described. Addition of phenoxyimines (FI) to (py)2Fe(CH2SiMe3)2 (py = pyridine) afforded the high-spin iron(II) alkyl derivatives, (FI)Fe(CH2SiMe3)(py) with varying N-imine substituents. With both neopentyl glycol-protected (BNeo) and pinacol-protected boronic ester (BPin) aryl nucleophiles, an iron-catalyzed cross-coupling method was realized that utilized synthetically preferred alkoxide bases. Optimal performance was observed in non-polar solvents with anisole and fluorobenzene identified as more benign alternatives to benzene. The scope of this transformation included high efficiency C(sp2)–C(sp3) bond formation with both primary and secondary alkyl bromides with electron-deficient aryl and heteroaryl nucleophiles. Radical clock experiments support the formation of electrophile-derived radicals during catalysis and experiments with pre-formed potassium aryl boronates demonstrate the role of boronate intermediates in transmetalation.
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Authors: Arun KP
Published: October 2022

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Pregnancy with A Sick Heart
Authors: Shajni Krishna G M  , Rupal Sipani  , Nidhi Sharma
Published: October 2022

Sick sinus syndrome (SSS) refers to a collection of cardiac arrhythmias associated with dysfunction of the sinoatrial node that commonly leads to disorders in cardiac rhythm and conduction. Mechanisms underlying the pathogenesis of sinus node dysfunction in SSS patients still appear unclear since degenerative fibrosis of nodal tissue has been the closest pathology associated but it is noteworthy to mention the occurrence of this condition in the younger population as well. Manifestations of this disease can be diverse with being totally asymptomatic to vague symptoms like bradyarrhythmia, tachyarrhythmia, syncope, palpitations and dizziness. Diagnosis can be quite difficult due to the stated diverse symptoms. Definite treatment is the replacement of a defective pacemaker with a synthetic pacemaker. Pregnancy with underlying heart disease should be carefully monitored and managed. However, pregnancy after surgical correction of underlying cardiac anomaly has shown a good prognosis in recent years due to the availability of various improved surgical techniques. Below is a depiction of how pregnancy with a prosthetic valve was managed effectively by a multidisciplinary approach that yielded a good outcome.
A Review on Biosurfactants
Authors: Jaysree R C  , Rajendran N
Published: October 2022

Biosurfactants are produced by different microorganisms like bacteria, algae, fungi on to the cell surface. They are amphipathic in nature which helps them to aggregate at the interfaces, thereby reducing the surface tension. They are characterized by the molecular weight into two i.e.  low molecular and high molecular. According to the different biomolecule such as protein, carbohydrate moiety attached, they have distinct and different structures which provide them different functions and applications in different fields. In this present review, the relationship among microorganism, biosurfactant and hydrocarbon has been described and the different applications in various industries have also been explained.
Insurance cases: analysis by machine learning
Authors: Kononova K. , Tarabanov M.
Published: October 2022

One of the main problems of insurance is fraud, when the client wants to get overpayments by distorting information about the insured event. However, traditional methods of insurance fraud combating require a lot of routine manual work and are not very effective. The paper proposes the development of a prototype of the insurance case monitoring system in order to detect fraud using machine-learning methods. The development was carried out on the example of a database of insurance cases, which has 38 variables and contains 1000 records of insurance claims. The dataset provides information on 1) client – 10 features; 2) insurance contract – 7 features; 3) incident – 21 features. Preliminary data processing, modeling and development of the monitoring system was carried out using the Python. Classifiers (logistic regression, gradient boosting and random forest) with different combinations of variables were built. For each model, the conjugation matrix, accuracy, specificity, sensitivity, and ROC curves were analyzed. Simulation results allowed to select 5 main variables for monitoring, 3 of which characterize the client, 2 – incident. The proposed monitoring system allows to identify the following patterns: 1) in most cases, fraudsters were managers and technical support staff; 2) customers, who were practicing chess or CrossFit, were more prone to fraud; 3) most of the fraud was recorded in severe damage; 4) in case of absence of contact with emergency services, a large amount of the claim indicated fraud.
Correlation-regression analysis of factors affecting inventories of production enterprise
Authors: Ostapenko Ya. , Pastukh D.
Published: October 2022

The article highlights the feasibility of correlation-regression analysis and inventory modeling at a manufacturing enterprise using applications. Inventory modeling will help to optimize them and further increase the profitability of the enterprise. The use of applications will speed up and simplify the modeling process and strengthen the analytical component. Among the modern variety of applications for statistical and econometric analysis, it is important to choose an effective software product, simple and easy to use, which does not require significant costs. It is offered to use a free, but no less high-quality R-Studio product, which is easy to use and fast to calculate. On the example of application of the free application program R-Studio the correlation-regression analysis is carried out and the regression model of stocks at the production enterprise of PJSC "Novokramatorsk Machine-Building Plant" is constructed. The influence of internal factors on the company's stocks, such as: net income from sales of products (goods, works, services), net financial result: profit, accounts payable for goods (works, services) and external: GDP and the dollar. According to the simulation results, the greatest influence among internal factors has the net income from sales of products (goods, works, services). Among external factors, GDP is the most influential. The constructed model is adequate, as evidenced by a significant indicator of the Fisher criterion and the coefficient of determination. 90% of the stocks of the studied enterprise depend on the selected factors. The construction of a matrix of correlation coefficients and correlation analysis confirmed the close relationship between the selected factors and their impact on stocks as a result. The example of PJSC "Novokramatorsk Machine-Building Plant" demonstrates the practical usefulness of inventory modeling using computer programs.