bluuebunny/crossref_metadata_2025 huggingface dataset:
Disrupted chromatin architecture in olfactory sensory neurons: looking for the link from COVID-19 infection to anosmia
Authors: Tan Zhen Wah , Toong Ping Jing , Guarnera Enrico , Berezovsky Igor N.
Published: April 2023

We tackle here genomic mechanisms of a rapid onset and recovery from anosmia—a potential diagnostic indicator for early-stage COVID-19 infection. Based on previous observations on how olfactory receptor (OR) gene expression is regulated via chromatin structure in mice, we hypothesized that the disruption of the OR gene expression and, respectively, deficiency of the OR function can be caused by chromatin reorganization taking place upon SARS-CoV-2 infection. We obtained chromatin ensemble reconstructions from COVID-19 patients and control samples using our original computational framework for the whole-genome 3D chromatin ensemble reconstruction. Specifically, we used megabase-scale structural units and effective interactions between them obtained in the Markov State modelling of the Hi-C contact network as an unput in the stochastic embedding procedure of the whole-genome 3D chromatin ensemble reconstruction. We have also developed here a new procedure for analyzing fine structural hierarchy with (sub)TAD-size units in local chromatin regions, which we apply here to parts of chromosomes containing OR genes and corresponding regulatory elements. We observed structural modifications in COVID-19 patients on different levels of chromatin organization, from the alteration of whole genome structure and chromosomal intermingling to reorganization of contacts between chromatin loops at the level of topologically associating domains. While complementary data on known regulatory elements point to potential pathology-associated changes within the overall picture of chromatin alterations, further investigation using additional epigenetic factors mapped on 3D reconstructions with improved resolution will be required for better understanding of anosmia caused by SARS-CoV-2 infection.
Thermodynamic, kinetic, and isotherm studies of Direct Blue 86 dye absorption by cellulose hydrogel
Authors: Shoaib Amany G. M. , Ragab Safaa , El Sikaily Amany , Yılmaz Murat , El Nemr Ahmed
Published: April 2023

In this study, cellulose hydrogels were simply fabricated by the chemical dissolution method using LiCl/dimethylacetamide as a new method, and the hydrogel produced was investigated for removing Direct Blue 86 (DB86) dye from the aquatic environment. The produced cellulose hydrogel (CAH) was characterized by FTIR, XRD, SEM, and TGA analyses. The removal efficiency of DB86 dye using CAH was achieved via a batch equilibrium process. The impact of pH, time of contact, CAH dosage, starting concentration of DB86 dye, and absorption temperature were scanned. The optimum pH for absorption of DB86 dye was determined to be 2. The absorption results obtained were scanned by Langmuir (LIM), Temkin (TIM), Freundlich (FIM), and Dubinin-Radushkevich (DRIM) isotherm models (IMs) and chi-square error (X2) function used to identify the best-fit IMs. The CAH had 53.76 mg/g as a maximum absorption capacity (Qm) calculated from the LIM plot. The TIM was the best fitted to the CAH absorption results. Kinetic absorption results were investigated by pseudo-first-order (PFOM), Elovich (EM), pseudo-second-order (PSOM), film diffusion (FDM), and intraparticle diffusion (IPDM) models. A PSOM with a highR2(> 0.99) accounted for the majority of the control over the absorption rate. The findings indicate that CAH can potentially remove the DB86 dye from wastewater.
A new samarium complex of 1,3-bis(pyridin-3-ylmethyl)thiourea on boehmite nanoparticles as a practical and recyclable nanocatalyst for the selective synthesis of tetrazoles
Authors: Moradi Parisa , Kikhavani Tavan , Abbasi Tyula Yunes
Published: April 2023

Boehmite is a natural and environmentally friendly compound. Herein boehmite nanoparticles were primarily synthesized and, then, their surface were modified via 3-choloropropyltrimtoxysilane (CPTMS). Afterwards, a new samarium complex was stabilized on the surface of the modified boehmite nanoparticles (Sm-bis(PYT)@boehmite). The obtained nanoparticles were characterized using thermogravimetric analysis (TGA), energy dispersive X-ray spectroscopy (EDS), Brunauer–Emmett–Teller (BET), wavelength dispersive X-ray spectroscopy (WDX), scanning electron microscope (SEM), Fourier transform infrared spectroscopy (FT-IR), Inductively coupled plasma mass spectrometry (ICP-MS), dynamic light scattering (DLS), and X-ray diffraction (XRD) pattern. Sm-bis(PYT)@boehmite was used as an environmentally friendly, efficient, and organic–inorganic hybrid nanocatalyst in the homoselective synthesis of tetrazoles in polyethylene glycol 400 (PEG-400) as a green solvent. Notably, Sm-bis(PYT)@boehmite is stable and has a heterogeneous nature. Thus, it can be reused for several runs without any re-activation.
Diastolic function evaluation in children with ventricular arrhythmia
Authors: Pietrzak Radosław , Książczyk Tomasz M. , Franke Magda , Werner Bożena
Published: April 2023

Premature ventricular contractions (PVC) are frequently seen in children. We evaluated left ventricular diastolic function in PVC children with normal left ventricular systolic function to detect whether diastolic function disturbances affect physical performance. The study group consisted of 36 PVC children, and the control group comprised 33 healthy volunteers. Echocardiographic diastolic function parameters such as left atrial volume index (LAVI), left atrial strains (AC-R, AC-CT, AC-CD), E wave, E deceleration time (Edt), E/E’ ratio, and isovolumic relaxation time (IVRT) were measured. In the cardiopulmonary exercise test (CPET), oxygen uptake (VO2 max) was registered. Evaluation of diastolic function parameters revealed statically significant differences between the patients and controls regarding Edt (176.58 ± 54.8 ms vs. 136.94 ± 27.8 ms, p < 0.01), E/E’ (12.6 ± 3.0 vs. 6.7 ± 1.0, p < 0.01), and IVRT (96.6 ± 19.09 ms. vs. 72.86 ± 13.67 ms, p < 0.01). Left atrial function was impaired in the study group compared to controls: LAVI (25.3 ± 8.2 ml/m2 vs. 19.2 ± 7.5 ml/m2, p < 0.01), AC-CT (34.8 ± 8.6% vs. 44.8 ± 11.8%, p < 0.01), and AC-R-(6.0 ± 4.9% vs. −11.5 ± 3.5%, p < 0.01), respectively. VO2 max in the study group reached 33.1 ± 6.2 ml/min/kg. A statistically significant, moderate, negative correlation between VO2 max and E/E’ (r = −0.33, p = 0.02) was found. Left ventricular diastolic function is impaired and deteriorates with the arrhythmia burden increase in PVC children. Ventricular arrhythmia in young individuals may be related to the filling pressure elevation and drive to exercise capacity deterioration.
Circulation of a digital community currency
Authors: Mattsson Carolina E. S. , Criscione Teodoro , Takes Frank W.
Published: April 2023

Circulation is the characteristic feature of successful currency systems, from community currencies to cryptocurrencies to national currencies. In this paper, we propose a network analysis approach especially suited for studying circulation given a system’s digital transaction records. Sarafu is a digital community currency that was active in Kenya over a period that saw considerable economic disruption due to the COVID-19 pandemic. We represent its circulation as a network of monetary flow among the 40,000 Sarafu users. Network flow analysis reveals that circulation was highly modular, geographically localized, and occurring among users with diverse livelihoods. Across localized sub-populations, network cycle analysis supports the intuitive notion that circulation requires cycles. Moreover, the sub-networks underlying circulation are consistently degree disassortative and we find evidence of preferential attachment. Community-based institutions often take on the role of local hubs, and network centrality measures confirm the importance of early adopters and of women’s participation. This work demonstrates that networks of monetary flow enable the study of circulation within currency systems at a striking level of detail, and our findings can be used to inform the development of community currencies in marginalized areas.
Analysis of influencing factors on gas film characteristics for hemispherical dynamic pressure motors
Authors: Zhang Yaping , Wang Yanzhong , Zhang Fuli , Niu Wentao , Yang Kai , Lu Boji
Published: April 2023

The hemispherical dynamic pressure motor (HDPM) has the advantages of high speed, wear resistance and stability, which is widely used in inertial instruments to produce the gyroscopic effect. The ultra-thin gas film between the stator and rotor of the motor provides dynamic pressure lubrication and bearing capacity, whose dynamic characteristics determine the motor performance. However, the influence mechanism of some key factors such as ball center distance on the film characteristics is not clear, which has become the bottleneck restricting the performance improvement of HDPMs. Therefore, in this paper, a series of gas film similarity models were solved under different geometric and working parameters, and the influence law of the ball center distance, rotor displacement and stopping process on the aerodynamic characteristics was obtained, the results show that these primary parameters have significant effects on the pressure distribution, resistance moment and frictional heat of the ultra-thin gas film. This work can not only provide a theoretical basis for the aerodynamic performance optimization of HDPMs, but also serve as a reference for the design of other aerodynamic instruments.
Income raises human well-being indefinitely, but age consistently slashes it
Authors: Li Chao , Managi Shunsuke
Published: April 2023

The relationships among human well-being, income, and age have long been debated. The association between human well-being and income is believed to be U-shaped, although the reasons remain elusive. A recent study shows a turning point in the link between human well-being and income; that is, increased income does not always improve well-being. However, the mechanisms of the effects of income and age on human well-being are unknown. Here, we illustrate the total cumulative effects of income and age on evaluated well-being through all observed causal pathways based on a 1.6-million-observation global dataset and the structural causal model. This is the first study to investigate those casual relationships globally. We find that an increase in age always reduces evaluated well-being, and the adverse effects are aggravated with age. Furthermore, increased income continuously improves human well-being, but the impacts gradually become marginal with higher income. Our results demonstrate that physical health improvement in older people is the most effective way to intervene against the harmful effects of age on well-being. Moreover, increased income may dramatically enhance the well-being of people living close to the poverty line.
Slow-down of deforestation following a Brazilian forest policy was less effective on private lands than in all conservation areas
Authors: da Silva Ramon Felipe Bicudo , de Castro Victoria Daniel , Nossack Fábio Ávila , Viña Andrés , Millington James D. A. , Vieira Simone Aparecida , Batistella Mateus , Moran Emilio , Liu Jianguo
Published: April 2023

Private lands are important for conservation worldwide, but knowledge about their effectiveness is still insufficient. To help fill this important knowledge gap, we analyzed the impacts of a national policy for conservation on private lands in Brazil, a global biodiversity hotspot with high potential for nature-based climate solutions. Through the evaluation of over 4 million private rural properties from the Rural Environmental Cadastre, we found that the last policy review in 2012 mainly affected the Amazon Forest. The amnesty granted to 80% of landowners of small properties prevented the restoration of 14.6 million hectares of agricultural land with a carbon sequestration potential of 2.4 gigatonnes. We found that private lands exist within the limits of public conservation areas and that between 2003 and 2020 deforestation rates in these private lands were higher than those across all conservation areas. The Rural Environmental Cadastre can be an effective tool for managing forests within private lands, with potential to integrate governance approaches to control deforestation and mitigate climate change.
Pr3+-doped nanoscintillators with concentration-quenching-free properties
Authors: Zhang Lin , Li Yantao , Ye Huiru , Zhao Lei , Song Qingwei , Du Weidong , Chen Xukai , Wei Wei
Published: April 2023

We demonstrate the concentration-quenching-free properties of the 406 nm emission in NaPrF4 nanoscintillators, which result from the large energy gap between the 1S0 and 1I6 states (ΔE = ∼25 000 cm−1) of Pr3+ ions.
HRMAS-NMR and simulation study of the self-assembly of surfactants on carbon nanotubes
Authors: Singh Raman Preet , Kaur Taranpreet
Published: April 2023

Sorption of Tween-80 and Pluronic F68 molecules on SWCNT and MWCNT by HRMAS-NMR and MD simulations.
Microfluidic static droplet generated quantum dot arrays as color conversion layers for full-color micro-LED displays
Authors: Zhu Licai , Tao Jin , Li Panyuan , Sun Wenchao , Li Jiwei , Fan KaiLi , Lv Jinguang , Qin Yuxin , Zheng Kaifeng , Zhao Baixuan , Zhao Yingze , Chen Yupeng , Tang Yingwen , Wang Weibiao , Liang Jingqiu
Published: April 2023

This paper presents an easy process based on microfluidics static-droplet-array (SDA) technology to fabricate quantum-dot (QD) arrays for micro-LED displays.
Indoxyl-glucosides bearing tethers for enzymatically triggered cross-linking
Authors: Sato Daisuke , Wu Zhiyuan , Dou Jinghuai , Son Juno , Lindsey Jonathan S.
Published: April 2023

Tethered indoxyl-glucosides upon treatment with β-glucosidase under physiological conditions afford the corresponding indigoid dye via oxidative dimerization.
Spontaneous valley polarization and valley-nonequilibrium quantum anomalous Hall effect in Janus monolayer ScBrI
Authors: Jia Kang , Dong Xiao-Jing , Li Sheng-Shi , Ji Wei-Xiao , Zhang Chang-Wen
Published: April 2023

By obtaining the real magnetic anisotropy energy (MAE) under different strains, when 1.5% < ε < 1.8%, due to spontaneous valley polarization, intrinsic out-of-plane (OOP) magnetic anisotropy, and a chiral edge state, the VQAHE can reliably appear between two HVM states.
Novel multi-material photo-curable resins containing high-performance photoinitiating systems and nano additives dedicated to 3D-VAT printing
Authors: Jankowska Magdalena , Chachaj-Brekiesz Anna , Trembecka-Wójciga Klaudia , Jarzębska Anna , Topa-Skwarczyńska Monika , Pilch Maciej , Ortyl Joanna
Published: April 2023

The suitability of new 9-[(E)-2-phenyl]anthracene derivatives with iodonium salt as high-performance photoinitiating systems for obtaining novel multi-material photo-curable nanocomposites resins containing dedicated to 3D-VAT printing.
Synthesis, molecular docking, and biological evaluation of [3,2-b]indole fused 18β-glycyrrhetinic acid derivatives against skin melanoma
Authors: Kumar Amit , Gupta Ragni , Rashid Haroon , Bhat Aalim Maqsood , Sharma Raghu Rai , Naikoo Shahid Hussain , Kaur Sarabjit , Tasduq Sheikh Abdullah
Published: April 2023

Synthesis and selective anti-melanoma activity of [3,2-b] indole fused 18β-glycyrrhetinic acid (GPD-12). GPD-12 significantly induced reactive oxygen species production in melanoma cells that triggered oxidative stress mediated cell death.
Development of fluorogenic substrates for colorectal tumor-related neuropeptidases for activity-based diagnosis
Authors: Nagano Norimichi , Ichihashi Yuki , Komatsu Toru , Matsuzaki Hiroyuki , Hata Keisuke , Watanabe Toshiaki , Misawa Yoshihiro , Suzuki Misa , Sakamoto Shingo , Kagami Yu , Kashiro Ayumi , Takeuchi Keiko , Kanemitsu Yukihide , Ochiai Hiroki , Watanabe Rikiya , Honda Kazufumi , Urano Yasuteru
Published: April 2023

We revealed higher neurolysin activity in the blood samples of patients with colorectal tumors, indicating that single-molecule neurolysin activity is a promising candidate for a blood biomarker for colorectal cancer diagnosis.
Tuning oxidative modification by a strong electric field using nanoESI of highly conductive solutions near the minimum flow rate
Authors: Han Zhongbao , Omata Nozomu , Matsuda Takeshi , Hishida Shoki , Takiguchi Shuuhei , Komori Ryoki , Suzuki Riku , Chen Lee Chuin
Published: April 2023

On-demand tunable oxidation is performed during the nanoESI-MS analysis by varying the nanoflow rate and the initial droplet size. The oxidation is initiated when the electric field of the droplet reaches ∼1.3 V nm−1.
Investigating anionic surfactant phase diagrams using dissipative particle dynamics: development of a transferable model
Authors: Gray Sarah J. , Walker Martin , Hendrikse Rachel , Wilson Mark R.
Published: April 2023

Dissipative particle dynamics (DPD) provides good predictions for the phase diagrams of SDS (sodium dodecyl sulfate) and 3 isomeric forms of LAS (linear alkylbenzene sulfonates) across an extensive concentration range.
Macrocycle polymeric networks based on a chair-like calix[4]pyrrole for the rapid and efficient adsorption of iodine from water
Authors: Zheng Zhiye , Lin Qiuyuan , Xie Linhuang , Chen Xiaolong , Zhou Huan , Lin Kunhua , Zhang Dengsong , Chi Xiaodong , Sessler Jonathan L. , Wang Hongyu
Published: April 2023

Two macrocycle polymeric networks (MPNs), C[4]P-TEPM and C[4]P-HEPM, were synthesized and found to exhibit iodine uptake capacities of 4.02 and 4.45 g g−1from a KI/I2solution, respectively. These values are among the highest reported for iodine adsorbent materials.
A rationally engineered specific near-infrared fluorogenic substrate of human pancreatic lipase for functional imaging and inhibitor screening
Authors: Hou Fan-Bin , Zhang Na , Hou Xu-Dong , Liu Wei , Fan Yu-Fan , Zhu Guang-Hao , Wu Yue , Sun Meng-Ru , Zhao Bei , Ge Guang-Bo , Wang Ping
Published: April 2023

A novel NIR fluorogenic substrate was rationally designed towards hPL, which can detect endogenous PL in living cells and tissues, and enable visual high-throughput screening of hPL inhibitors.
ESIPT-PET based triphenylamine-anthraquinone probe for the detection of phosgene: DFT studies, real-time application in soil samples and test strips
Authors: Abhijnakrishna Ramakrishnan , Velmathi Sivan
Published: April 2023

Triphenylamine-anthraquinone probe for Phosgene detection and its prominent features.
Biomass-derived magnetic nanocomposites modified by choline chloride/citric acid based natural deep eutectic solvents for the magnetic solid phase extraction of trypsin
Authors: Chen Jing , Xu Fangting , Wang Yuzhi
Published: April 2023

The application of biomass-derived magnetic nanocomposites modified by choline chloride/citric acid based natural deep eutectic solvents in the magnetic solid phase extraction of trypsin.
The application of nanoparticles in point-of-care testing (POCT) immunoassays
Authors: Hou Fengping , Sun Shiqi , Abdullah Sahibzada Waheed , Tang Yu , Li Xiongxiong , Guo Huichen
Published: April 2023

POCT technology has shown promise for rapid diagnosis. POCT nanoparticle-based immunoassays can be used to detect different targets with high sensitivity, selectivity, and affordability.
A multifaceted biomimetic periosteum with a lamellar architecture and osteogenic/angiogenic dual bioactivities
Authors: Zhao Yonggang , Xiong Yang , Zheng Jingchuan , Kongling Wenyao , Chen Junlin , Li Chengli , Hu Peilun , Yang Shuhui , Wang Xiumei
Published: April 2023

An artificial periosteum composed of hierarchically assembled Mg-doped MC microfibrils with a biomimetically rotated lamellar structure and osteogenic/angiogenic activities was successfully fabricated via a “multiscale cascade regulation” strategy.
Real-time monitoring of the release of multiple payloads from nanomaterials
Authors: Janprasit Jindaporn , Schulte Albert , Crespy Daniel
Published: April 2023

We overcome limitations of conventional methods to monitor the release of two payloads in situ.
Tandem Pd-catalyzed annulation/coupling of acetylenic enamines with aryl triflates
Authors: Błocka Aleksandra , Ostapko Jakub , Chaładaj Wojciech
Published: April 2023

Application of aryl triflates and terminal acetylenic enamines as surrogates of unactivated ketones enables an unprecedented Pd-catalyzed 5-exo-dig cyclization/cross coupling sequence.
Anomalous glucose-responsive rheological changes in a boronic acid-modified hyaluronan
Authors: Miki Ryotaro , Yamaki Tsutomu , Uchida Masaki , Natsume Hideshi
Published: April 2023

Herein, we report anomalous glucose (Glc)-responsive gelation/solation in 3-aminophenylboronic acid-modified hyaluronic acid.
“Medium-ring” strategy enables high-performance narrowband pure-blue multi-resonance emitters: boost provided by a unique perpendicular geometry
Authors: Xiao Xin , Lei Bowen , Wu Di , Bin Zhengyang
Published: April 2023

Based on a “medium-ring” strategy, a pure-blue narrowband emitter, TBA-BCz-BN, with superior device performance was developed by attaching a heptagonal donor to BCz-BN.
Flux growth and phase diversity of the triple oxides of transition metals (Mn,Fe,Ga)2O3in multicomponent fluxes based on Bi2O3–MoO3–B2O3–Na2O
Authors: Moshkina Evgeniya , Seryotkin Yurii , Bayukov Oleg , Molokeev Maxim , Kokh Dieter , Smorodina Ekaterina , Krylov Alexander , Bezmaternykh Leonard
Published: April 2023

The influence of Bi2O3–MoO3–B2O3–Na2O flux components on the crystallization of the triple oxides (Mn,Fe,Ga)2O3is studied. 9 single crystal samples of bixbyite, spinel and orthorhombic phase are obtained and characterized.
Cavity-catalyzed hydrogen transfer dynamics in an entangled molecular ensemble under vibrational strong coupling
Authors: Fischer Eric W. , Saalfrank Peter
Published: April 2023

Light-matter entanglement in a cavity-catalysed hydrogen transfer ensemble reaction model is studied, its relevance for thermal rate enhancement is discussed and entanglement-related deviations from reactive single-molecule models are analyzed.
The effect of phthalocyanine's periphery on the biological activities of carbazole-containing metal phthalocyanines
Authors: Farajzadeh Nazli , Yasemin Yenilmez H. , Bahar Dilek , Kuşçulu Nilgün Güler , Selvi Emine Kılıçkaya , Bayır Zehra Altuntaş
Published: April 2023

In this study, the effect of metal ions, substituent (type, number, and position), and gold nanoparticles on the biological properties of some carbazole-containing phthalocyanine-gold nanoconjugates were extensively investigated and compared with the literature.
Heterogeneous chemistry of methyl ethyl ketone on mineral oxide surfaces: impacts of relative humidity and nitrogen dioxide on product formation
Authors: Hettiarachchi Eshani , Grassian Vicki H.
Published: April 2023

Heterogeneous reactions of methyl ethyl ketone on mineral oxide particle surfaces in the presence of relative humidity and nitrogen dioxide can yield a number of different compounds including oligomers and oxidized products that strongly adsorb onto the particle surface.
Application ofRhodococcus jostiiRHA1 glycolate oxidase as an efficient accessory enzyme for lignin conversion by bacterial Dyp peroxidase enzymes
Authors: Alruwaili Awatif , Rashid Goran M. M. , Bugg Timothy D. H.
Published: April 2023

Lignin oxidation by bacterial dye-decolorizing peroxidase enzymes requires hydrogen peroxide as a co-substrate, an unstable and corrosive oxidant.
A cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system with lubrication maintenance for osteoarthritis treatment
Authors: Zhang Miao , Peng Xu , Ding Yuan , Ke Xiang , Ren Kai , Xin Qiangwei , Qin Meng , Xie Jing , Li Jianshu
Published: April 2023

It is found that a cyclic brush zwitterionic polymer based pH-responsive nanocarrier-mediated dual drug delivery system can effectively treat early OA through synergistic lubrication, dual-drug sequence controlled release, and anti-inflammation.
Core–shell structured Fe–N–C wrapped by an ultrathin porous carbon shell as a robust electrocatalyst for the oxygen reduction reaction
Authors: Yue Bin , Yang Kang , Xie Huaming , Lei Ying , Li Jianying , Si Yujun
Published: April 2023

Porous carbon supported FeNx catalysts have become one of the candidates to replace platinum group metal (PGM) catalysts for the oxygen reduction reaction (ORR) due to their high intrinsic reactivity and substantial accessible active sites.
Ring expansion/opening reactions of epoxy ene-amides: access to azabicyclononene, tetrahydropyridine and tetrazole scaffolds
Authors: Suraj  , Swamy K. C. Kumara
Published: April 2023

Epoxy benzene sulfonamides and substituted chloro-acrylaldehydes under Lewis acid mediation afford azabicyclononene or tetrahydropyridine frameworks; in the presence of additional Me3SiN3, 1,2-substituted tetrazoles are the products.
On the nature of optical activity in chiral transition metal complexes: [Pd(Me)2(BINAP)]
Authors: Fehn Natalie , Strauss Melanie , Jandl Christian , Drees Markus , Heiz Ueli , Köhler Klaus , Kartouzian Aras
Published: April 2023

Induced circular dichroism study of an asymmetric homogeneous catalyst reveals chirality transfer from ligands to the catalytically active metal centre.
Superconductivity in functionalized niobium-carbide MXenes
Authors: Sevik Cem , Bekaert Jonas , Milošević Milorad V.
Published: April 2023

We reveal the effects of Cl and S functionalization on the superconducting properties of niobium carbide (Nb2C) MXene crystals in bulk-layered and monolayer form, based on first-principles calculations combined with Eliashberg theory.
Plastics to fertilizer: guiding principles for functionable and fertilizable fully bio-based polycarbonates
Authors: Abe Takumi , Kamiya Takehiro , Otsuka Hideyuki , Aoki Daisuke
Published: April 2023

Bio-based polycarbonates, copolymers of isosorbide and 1,3:4,6-di-O-benzylidene-d-mannitol, were successfully converted to fertilizerviaammonolysis.
A Sc(OTf)3-catalyzed one-pot two-step approach for spiro-oxindole dihydropyridine derivatives initiated by N-olefination of MBH carbonates
Authors: Yan Zhen-Hui , Lu Run , Peng Cheng , Tang Jie , Fang Huaying , Zhan Gu , He Xiang-Hong , Huang Wei
Published: April 2023

An efficient one-pot, two-step, three-component reaction of isatin-derived MBH carbonates, sulfilimines, and epoxides was achieved, thus affording pharmaceutically important spiro-oxindole dihydropyridines.
Ultrasonic-assisted synthesis of magnetic recyclable Fe3O4/rice husk biochar based photocatalysts for ciprofloxacin photodegradation in aqueous solution
Authors: Toan Tran Quoc , Mai Nguyen Thi , Trang Hoang Minh , Van Hao Pham , Van Thanh Dang
Published: April 2023

A magnetic recyclable biochar based photocatalysts was fabricated via a novel facile process which coupling ultrasonic-assisted impregnation and precipitation reaction, and its applicability for ciprofloxacin photodegradation was studied.
Magnetic clusters and ferromagnetic spin glass in the novel hexagonal perovskite 12R-Ba4SbMn3O12
Authors: Yan Xiaohui , Wu Junkun , Lei Xiuyun , He Lunhua , Guo Wenbin , Kuang Xiaojun , Yin Congling
Published: April 2023

The novel 12-layered hexagonal perovskite Ba4SbMn3O12 displays Sb/Mn cationic order and a ferromagnetic spin glass transition at Tg = ∼11.5 K from a high temperature paramagnetic state of the Mn3 magnetic cluster.
Synthesis and characterization of novel solid-supported salicylate-based ionic liquid for adsorptive removal of Pb(ii) and Ni(ii) ions from aqueous solution
Authors: Kamaruddin Nur Anis Liyana , Taha Mohd Faisal , Romil Avisenna Muhammad , Mohd Rasdi Fairuz Liyana
Published: April 2023

Novel solid-supported ionic liquid (Si-Sal-SSIL) was synthesized by immobilization of 1-methyl-3-(3-trimethoxysilylpropylimidazolium) salicylate [MTMSPI][Sal] ionic liquid onto the activated silica gel.
Reinforcement effect in tandemly sulfonated, partially fluorinated polyphenylene PEMs for fuel cells
Authors: Guo Lin , Masuda Akihiro , Miyatake Kenji
Published: April 2023

The chemically stable, partially fluorinated polyphenylene ionomer membranes reinforced with porous polyethylene substrates achieved superior durability to survive more than 20 000 cycles in severe accelerated durability test.
A modular aldol approach for internal fluorescent molecular rotor chalcone surrogates for DNA biosensing applications
Authors: Johnson Ryan E. , Murray Makay T. , Bycraft Lucas J. , Wetmore Stacey D. , Manderville Richard A.
Published: April 2023

Insertion of an indanone handle into DNA oligonucleotides permits base-catalyzed aldol to create fluorescent molecular rotor (FMR) chalcones with turn-on fluorescence and brightness suitable for biosensing applications.
Investigation into antifreeze performances of natural amino acids for novel CPA development
Authors: Ma Jianfan , Zhang Xiangyu , Cui Zhongxin , Zhao Meirong , Zhang Lei , Qi Haishan
Published: April 2023

The antifreeze performance of 18 water-soluble natural amino acids was evaluated, and an amino acids-based CPA was prepared by combining Phe (recrystallization inhibition agent) and Pro (osmotic pressure regulator), and was successfully used for the cryoprotection of RBCs.
Controlling the semiconductor–metal transition in Cu-intercalated TiSe2 by applying stress
Authors: Morozova Natalia V. , Usik Aleksandr Yu. , Korobeinikov Igor V. , Titov Alexander N. , Ovsyannikov Sergey V.
Published: April 2023

An abrupt semiconductor–metal transition in CuxTiSe2 single crystals with x ≤ 0.1 under a high pressure of 1–3 GPa has been revealed. Band gaps and their pressure coefficients of the crystals have been determined.
A high linearity and energy-efficient artificial synaptic device based on scalable synthesized MoS2
Authors: Zhao Yuxin , Jin Yuanhao , Wang Xing , Zhao Jie , Wu Sanming , Li Mengjuan , Wang Jiaping , Fan Shoushan , Li Qunqing
Published: April 2023

Synaptic devices based on 2D materials are being considered as potential solutions to mimic the behavior of synapses in neuromorphic computing.
Ultra-stable liquid crystal droplets coated by sustainable plant-based materials for optical sensing of chemical and biological analytes
Authors: Aery Shikha , Parry Adele , Araiza-Calahorra Andrea , Evans Stephen D. , Gleeson Helen F. , Dan Abhijit , Sarkar Anwesha
Published: April 2023

The plant-based polymer and microgel act as effective emulsifiers for liquid crystal (LC)-in-water emulsions where microgels provide better storage stability and response to chemical and biological analytes with 5× lower detection limit than the protein.
Predicting Behavioral Threshold at 6 and 8 kHz for Children and Adults Based on the Auditory Brainstem Response
Authors: Porter Heather L. , Dubas Christina , Vicente Manuel , Buss Emily , Bishop Danielle , Kaminski Jan
Published: April 2023

Purpose:

Common clinical application of auditory brainstem response (ABR) testing is limited to 0.25–4 kHz. Prior research has demonstrated associations between ABR and behavioral thresholds for tone burst stimuli > 4 kHz in adults, but there are no comparable data for children. The ability to predict behavioral thresholds > 4 kHz clinically based on the ABR would provide valuable audiologic information for individuals who are unable to provide behavioral thresholds. This study included children with hearing loss and children with normal hearing to determine the association between ABR and behavioral thresholds at 6 and 8 kHz.

Method:

ABR and behavioral thresholds were obtained for children ages 4.7–16.7 years (
M
= 10.5,
SD
= 3.4) with sensorineural hearing loss (
n
= 24) or normal hearing sensitivity (
n
= 16) and for adults ages 18.4–54.4 years (
M
= 32.7,
SD
= 10.4) with sensorineural hearing loss (
n
= 13) or normal hearing sensitivity (
n
= 11). Thresholds obtained for 6 and 8 kHz using ABR and conventional audiometry were compared.

Results:

Differences between ABR and behavioral thresholds averaged 5–6 dB for both children and adults for both test frequencies, with differences of ≤ 20 dB in all instances. Linear mixed modeling for data from participants with hearing loss suggested that ABR threshold is a good predictor of behavioral threshold at 6 and 8 kHz for both children and adults. Test specificity was 100%; no participants with behavioral thresholds ≤ 20 dB HL had ABR thresholds > 25 dB nHL.

Conclusions:

Initial evidence suggests that ABR testing at 6 and 8 kHz is reliable for estimating behavioral threshold in listeners with hearing loss and accurately identifies normal hearing sensitivity. The results of this study contribute to efforts to improve outcomes for vulnerable populations by reducing barriers to clinical implementation of ABR testing at > 4 kHz.
The Impact of Bimodal Hearing on Speech Acoustics of Vowel Production in Adult Cochlear Implant Users
Authors: Luo Xin , Daliri Ayoub
Published: April 2023

Purpose:

This study aimed to investigate the acoustic changes in vowel production with different forms of auditory feedback via cochlear implant (CI), hearing aid (HA), and bimodal hearing (CI + HA).

Method:

Ten post–lingually deaf adult bimodal CI users (aged 50–78 years) produced English vowels /i/, /ɛ/, /æ/, /ɑ/, /ʊ/, and /u/ in the context of /hVd/ during short-term use of no device (ND), HA, CI, and CI + HA. Segmental features (first formant frequency [F1], second formant frequency [F2], and vowel space area) and suprasegmental features (duration, intensity, and fundamental frequency [fo]) of vowel production were analyzed. Participants also categorized a vowel continuum synthesized from their own productions of /ɛ/ and /æ/ using HA, CI, and CI + HA.

Results:

F1s of all vowels decreased;F2s of front vowels but not back vowels increased; vowel space areas increased; and vowel durations, intensities, andfos decreased with statistical significance in the HA, CI, and CI + HA conditions relative to the ND condition. Onlyfos were lower, and vowel space areas were larger with CI and CI + HA than with HA. Average changes info, intensity, andF1from the ND condition to the HA, CI, and CI + HA conditions were positively correlated. Most participants did not show a typical psychometric function for vowel categorization, and thus, the relationship between vowel categorization and production was not tested.

Conclusions:

The results suggest that acoustic, electric, and bimodal hearing have a measurable impact on vowel acoustics of post–lingually deaf adults when their hearing devices are turned on and off temporarily. Also, changes infoandF1with the use of hearing devices may be largely driven by changes in intensity.
Miniature Linguistic Systems for Individuals With Autism Spectrum Disorder: A Systematic Review and Meta-Analysis
Authors: Simeone Paul J. , Schlosser Ralf W. , Frampton Sarah E. , Shane Howard C. , Wendt Oliver
Published: April 2023

Purpose:

Miniature linguistic systems (also known as matrix training) is a method of organizing learning targets to achieve generative learning or recombinative generalization. This systematic review is aimed at determining whether matrix training is effective for individuals with autism spectrum disorder (ASD) in terms of improving recombinative generalization for instruction-following, expressive language, play skills, and literacy skills.

Method:

A systematic review methodology was employed to limit bias in the various review stages. A multifaceted search was conducted. Potential primary studies were imported into Covidence, a systematic review software, and inclusion criteria were applied. Data were extracted regarding (a) participant characteristics, (b) matrix designs, (c) intervention methods, and (d) dependent variable. A quality appraisal using the What Works Clearinghouse (WWC) Single-Case Design Standards (Version 1.0, Pilot) was carried out. In addition to the visual analysis of the data, an effect size estimate, non-overlap of all pairs (NAP), was generated for each participant. Independentttests and between-subjects analyses of variance were conducted to identify moderators of effectiveness.

Results:

Twenty-six studies including 65 participants met criteria for inclusion. All included studies were single-case experimental designs. Eighteen studies received a rating ofMeets Standards Without ReservationsorMeets Standards With Reservations. The aggregated combined NAP scores for acquisition, recombinative generalization, and maintenance of a range of outcomes were in the high range.

Conclusions:

Findings suggested that matrix training is an effective teaching method for individuals with ASD for acquisition, recombinative generalization, and maintenance of a range of outcomes. Statistical analyses to identify moderators of effectiveness were insignificant. Based on the WWC Single-Case Design Standards matrix training meets criteria to be considered an evidence-based practice for individuals with ASD.
Examining Perspectives of Latina Mothers and Speech-Language Pathologists Through Dyadic Interviews: Implications for Latine Children on the Autism Spectrum
Authors: Esquilín Nieves Astrid A. , Danzak Robin L.
Published: April 2023

Purpose:

This qualitative pilot study explored cultural perspectives and needs of two bilingual (Spanish/English) Latina mothers with children on the autism spectrum in conversations with their children's speech-language pathologists (SLPs), one identifying as Mexican American and the other identifying as White American.

Method:

Dyadic interviews were used to promote dialogue and learning opportunities for the participants. Two dyads (mothers and SLPs) participated, completing background questionnaires, dyadic interviews, and post-interview written reflections.

Results:

Three main themes emerged from the qualitative analysis of the dyadic interviews:
comunicación
(communication), language, and challenge. Post-interview written reflections evidenced increased advocacy skills for the mothers and heightened awareness regarding communication style for the SLPs.

Conclusion:

The lived experiences revealed by all participants offer several implications: (a) the value of extended conversations between caregivers and service providers, (b) caregiver sacrifices, (c) the importance of cultural sensitivity for SLPs, and (d) positive outcomes from online learning for children on the autism spectrum.
Toward a Model of Reciprocal Carryover: Learning From Communication Systems of Families of Nonspeaking Bilingual Children
Authors: Padía Lilly
Published: April 2023

Purpose:

Children at the intersections of language learning, racialization, and dis/ability status experience systems of power in a very particular way. This work amplifies the “voices” of bilingual nonspeaking children and their families to upend the notion of educational and medical professionals as the experts. It positions familial ways of being and knowing as central to learning and offers educators tools to actively collaborate with and follow the lead of children and families to engage in “reciprocal carryover.”

Method:

This clinical focus article is built on a series of semistructured interviews and observations with caregivers, young children, and educators—specifically, two case studies of bilingual nonspeaking young children in the United States and their transnational families. Circumventing school and medical spaces and going directly to young children and families was a methodological choice to identify the family as the epicenter of languaging and learning.

Results:

Each case study demonstrates a system that was created to bolster the communication of these historically subaltern families. From systems of social capital exchanges to intrafamilial nonverbal communication systems, the families in the study engage in and share systems they created to navigate the larger system of special education that so often positions multilingual, transnational families and their dis/abled children as nonknowers. The author offers strategies for educators to learn alongside children and families to engage in “reciprocal carryover.”

Conclusions:

This work highlights the communication and languaging systems children and families co-construct beyond the bounds of formal education and supports educators in following their lead. It offers a roadmap for educators, families, and children to co-construct communication practices together.
Parallel distributed compensation scheme for chaotic masking system via Rivest cipher 4 stream cipher
Authors: Hsiao Feng‐Hsiag
Published: April 2023

This study presents a design methodology for Takagi‐Sugeno (T‐S) fuzzy models‐based secure communications in multiple time‐delay chaotic (MTDC) systems with Rivest cipher 4 (RC4) algorithm. The main advantage of the RC4 algorithm is that the key length does not affect the encryption and decryption speeds. To block a hacker from stealing a message, this study proposes increasing the complexity of an encrypted message (ciphertext) using a method of double encryption using the RC4 algorithm and chaotic masking. As a result, this more secure communications system can effectively defend the encrypted message (ciphertext). First, the RC4 algorithm and a key are used to encrypt the initial message (plaintext). To enhance security, the encrypted message (ciphertext) is then converted into an encrypted signal, which is a double encryption using chaotic masking. Additionally, an improved genetic algorithm (IGA) is adopted in this study, it can seek better feedback gains of fuzzy controllers to speed up the synchronization. In accordance with the IGA, a model‐based fuzzy controller is synthesized to exponentially stabilize the error systems so that the trajectories of the slave systems can approach those of the master systems. Finally, a numerical example with simulations is provided to illustrate the effectiveness of the proposed method.
Binary asteroid dissociation and accretion around white dwarfs
Authors: Jin Zeping , Li Daohai , Zhu Zong-Hong
Published: April 2023

About 25–50% of white dwarfs (WDs) show metal lines in their spectra. Among the widely accepted explanations for this effect is that these WDs are accreting asteroids that are perhaps flung onto the WDs by a planet via resonance, for instance. A number of theoretical works have looked into the accretion of asteroids onto WDs and obtained a fair agreement with the observed accretion rate. However, it is solely a very recent study (referenced in this work) that has taken asteroid binarity into consideration, examining the scattering between an asteroid binary and planets and showing that a dissociation and ejection of the former might result and the effect on WD metal accretion is likely to be weak. Here, we investigate the close encounter between an asteroid binary and the central WD and consider how the binary’s dissociation may affect the WD’s accretion. We find that depending on the orbital and physical properties, the components may acquire orbits that are significantly different (even on the order of unity) from that of the parent binary. We assumed all the inner main belt asteroids are binaries and we studied their accretion onto the solar WD under the perturbation of the giant planets. We find that compared to the case without binaries, the components’ accretion may be postponed (or put forward) by millions of years or more, as the objects may be taken out of (or driven deeper into) the resonance due to the sudden orbital change upon dissociation. However, the overall influence of binary dissociation on the accretion rate is not very significant.
Management, vaccination status and COVID-19 morbidity of patients with Gaucher disease in Germany during the COVID-19 pandemic
Authors: Niederau Claus , Regenbogen Claudia , Fruehauf Hans-Martin , Merkel Martin , Ziagaki Athanasia , Mengel Eugen , Baerwald Christoph , Muschol Nicole , Staufner Christian , Lampe Christina , Gillessen Anton , Koehler Jan Philipp , vom Dahl Stephan
Published: April 2023

Background Continuation of standard management of Gaucher disease
(GD) has been challenging during the COVID-19 pandemic, resulting in infrequent/missed
infusions and follow-up appointments. Little data are available on the consequences of these
changes and on the SARS-CoV-2 vaccinations in German GD patients.

Methods A survey with 22 questions about GD management during the
pandemic was sent to 19 German Gaucher centres. It was answered by 11/19 centres caring for
257 GD patients (almost ¾ of the German GD population); 245 patients had type 1 and 12 had
type 3 GD; 240 were ≥ 18 years old.

Results Monitoring intervals were prolonged in 8/11 centres from
a median of 9 to 12 months. Enzyme replacement therapy (ERT) was changed to home ERT in 4
patients and substituted by oral substrate reduction therapy (SRT) in 6 patients. From March
2020 to October 2021, no serious complications of GD were documented. Only 4 SARS-CoV-2
infections were reported (1.6%). Two infections were asymptomatic and two mild; all occurred
in adult type 1, non-splenectomized patients on ERT. Vaccination rate in adult GD was 79.5%
(95.3% mRNA vaccines). Serious vaccination complications were not reported.

Conclusions The COVID-19 pandemic has lowered the threshold for
switching from practice- or hospital-based ERT to home therapy or to SRT. No major GD
complication was documented during the pandemic. Infection rate with SARS-CoV-2 in GD may
rather be lower than expected, and its severity is mild. Vaccination rates are high in GD
patients and vaccination was well tolerated.
Clinical Manifestation of AGE-RAGE Axis in Neurodegenerative and
Cognitive Impairment Disorders
Authors: Naz Sabreena , Mahmood Tarique , Gupta Ramesh , Siddiqui Mohammed Haris , Ahsan Farogh , Ansari Vaseem Ahamad , Shamim Arshiya , Rizvi Ali Abbas
Published: April 2023

The receptor of Advanced Glycation Endproducts (RAGE) and Advanced Glycation
Endproducts (AGE) have multiple functions in our body and their restraint are
being observed in neurodegenerative and memory impairment disorders. The review
of different pathways allows an understanding of the probable mechanism of
neurodegeneration and memory impairment involving RAGE and AGE. Commonly we
observe AGE accumulation in neural cells and tissues but the extent of
accumulation increases with the presence of memory impairment disorder. The
presence of AGEs can also be seen in morbid accumulation, pathological
structures in the form of amyloid clots, and nervous fibrillary tangles in
Alzheimer’s Disease (AD) and memory impairment disease.

Many neuropathological and biochemical aspects of AD are explained by AGEs,
including widespread protein crosslinking, glial activation of oxidative stress,
and neuronal cell death. Oxidative stress is due to different reasons and
glycation end products set in motion and form or define various actions which
are normally due to AGE changes in a pathogenic cascade. By regulating the
transit of ß-amyloid in and out of the brain or altering inflammatory
pathways, AGE and it’s ensnare receptor such as soluble RAGE may
function as blockage or shield AD development. RAGE activates the
transcription-controlling factor Necrosis Factor (NF-κB) and increases
the protraction of cytokines, like a higher number of Tumor Necrosis Factor
(TNF-α) and Interleukin (IL-I) by inducing several signal transduction
cascades. Furthermore, binding to RAGE can pro-activate reactive oxygen species
(ROS), which is popularly known to cause neuronal death.
Liebe Leserinnen und Leser,
Authors: Greitemann Bernhard
Published: April 2023

die COVID Pandemie hat uns nun mehr als 2 Jahre im Griff gehabt und den Alltag
für alle erschwert. Dies betraf insbesondere Menschen mit
Rehabilitationsbedarf und Rehabilitationseinrichtungen. Umso erfreulicher war es,
dass in diesem Winter die Pandemiewelle erkennbar nicht so hart zuschlug, wie in den
Jahren zuvor, die Verläufe waren in der Regel milder. Nichtsdestotrotz gibt
es dennoch viele Betroffene, die teils schwere somatische, aber auch psychische
Schäden durch die Erkrankung, auch in diesem Winter, erlitten haben. Die
Lockerungen im Infektionsschutz, die Aufhebung der Maskenpflicht in den Kliniken
ermöglichen vielen Rehabilitanden wieder eine aktivere Form der
Rehabilitation. Dies ist zu begrüßen. Nichtsdestotrotz gilt es auch
zu beachten, dass wir weiter verpflichtet sind, evtl. immungeschwächte
Rehabilitanden, Risikogruppen wie beispielsweise Patienten mit cardio-pulmonaler
Insuffizienz zu schützen. Die üblichen Hygienevorschriften wie
Abstand, Desinfektion bleiben daher ein MUSS!