bluuebunny/crossref_metadata_2025 huggingface dataset:
Solving the puzzle of quality of life in cancer: integrating causal inference and machine learning for data-driven insights
Authors: Bozcuk Hakan Şat , Alemdar Mustafa Serkan
Published: August 2024

Background

Understanding the determinants of global quality of life in cancer patients is crucial for improving their overall well-being. While correlations between various factors and quality of life have been established, the causal relationships remain largely unexplored. This study aimed to identify the causal factors influencing global quality of life in cancer patients and compare them with known correlative factors.

Methods

We conducted a retrospective analysis of European Organization for Research and Treatment of Cancer Quality of Life Questionnaire data, alongside demographic and disease-related features, collected from new cancer patients during their initial visit to an oncology outpatient clinic. Correlations with global quality of life were identified using univariate and multivariate regression analyses. Causal inference analysis was performed using two approaches. First, we employed the Dowhy Python library for causal analysis, incorporating prior information and manual characterization of an acyclic graph. Second, we utilized the Linear Non-Gaussian Acyclic Model (LiNGAM) machine learning algorithm from the Lingam Python library, which automatically generated an acyclic graph without prior information. The significance level was set at p < 0.05.

Results

Multivariate analysis of 469 new admissions revealed that disease stage, role functioning, emotional functioning, social functioning, fatigue, pain and diarrhea were linked with global quality of life. The most influential direct causal factors were emotional functioning, social functioning, and physical functioning, while the most influential indirect factors were physical functioning, emotional functioning, and fatigue. Additionally, the most prominent total causal factors were identified as type of cancer (diagnosis), cancer stage, and sex, with total causal effect ratios of -9.47, -4.67, and − 1.48, respectively. The LiNGAM algorithm identified type of cancer (diagnosis), nausea and vomiting and social functioning as significant, with total causal effect ratios of -9.47, -0.42, and 0.42, respectively.

Conclusions

This study identified that causal factors for global quality of life in new cancer patients are distinct from correlative factors. Understanding these causal relationships could provide valuable insights into the complex dynamics of quality of life in cancer patients and guide targeted interventions to improve their well-being.
Sorption of chromium from aqueous solutions using Fucus vesiculosus algae biosorbent
Authors: Asaad Amany A.
Published: August 2024

The presence of heavy metals in wastewater is an environmental concern and the current treatment procedures are very expensive so it is necessary to find effective and inexpensive biosorbents. In this study, Fucus vesiculosus was used as a biosorbent for the biosorption of Cr(III) ions from the aqueous solutions. Biosorption parameters, such as pH, adsorbent dose, contact time, and initial concentrations of Cr(III) had the most impact on the sorption process. The required pH value for sorption was 5, the biosorbent dose was 4.0 g/L, the contact time was seen to occur after 90 min, and the Cr(III) removal decreased from 98.9 to 92%. The maximum biosorption capacity of chromium was 14.12 mg/g. FTIR analysis of Fucus vesiculosus biomass before the sorption process contains carboxyl, amino, hydroxyl, alkyne, and carbonyl groups, and according to the analysis after the sorption process, it was found that Cr(III) metal ions were incorporated within the sorbent during the interaction with (=C–H) active functional groups. The biosorption data were found to be perfectly suited by Langmuir equilibrium isotherm model. According to the results of this study, Fucus vesiculosus is an effective biosorbent for the removal of Cr(III) from aqueous solutions.
RECIST 1.1 assessments variability: a systematic pictorial review of blinded double reads
Authors: Iannessi Antoine , Beaumont Hubert , Ojango Christine , Bertrand Anne-Sophie , Liu Yan
Published: August 2024

Reader variability is intrinsic to radiologic oncology assessments, necessitating measures to enhance consistency and accuracy. RECIST 1.1 criteria play a crucial role in mitigating this variability by standardizing evaluations, aiming to establish an accepted “truth” confirmed by histology or patient survival. Clinical trials utilize Blind Independent Centralized Review (BICR) techniques to manage variability, employing double reads and adjudicators to address inter-observer discordance effectively.

It is essential to dissect the root causes of variability in response assessments, with a specific focus on the factors influencing RECIST evaluations. We propose proactive measures for radiologists to address variability sources such as radiologist expertise, image quality, and accessibility of contextual information, which significantly impact interpretation and assessment precision. Adherence to standardization and RECIST guidelines is pivotal in diminishing variability and ensuring uniform results across studies.

Variability factors, including lesion selection, new lesion appearance, and confirmation bias, can have profound implications on assessment accuracy and interpretation, underscoring the importance of identifying and addressing these factors. Delving into the causes of variability aids in enhancing the accuracy and consistency of response assessments in oncology, underscoring the role of standardized evaluation protocols and mitigating risk factors that contribute to variability. Access to contextual information is crucial.

Critical relevance statement

By understanding the causes of diagnosis variability, we can enhance the accuracy and consistency of response assessments in oncology, ultimately improving patient care and clinical outcomes.

Key Points

Baseline lesion selection and detection of new lesions play a major role in the occurrence of discordance.

Image interpretation is influenced by contextual information, the lack of which can lead to diagnostic uncertainty.

Radiologists must be trained in RECIST criteria to reduce errors and variability.

Graphical Abstract
DNA stable isotope probing reveals the impact of trophic interactions on bioaugmentation of soils with different pollution histories
Authors: Nieto Esteban E. , Jurburg Stephanie D. , Steinbach Nicole , Festa Sabrina , Morelli Irma S. , Coppotelli Bibiana M. , Chatzinotas Antonis
Published: August 2024

Background

Bioaugmentation is considered a sustainable and cost-effective methodology to recover contaminated environments, but its outcome is highly variable. Predation is a key top-down control mechanism affecting inoculum establishment, however, its effects on this process have received little attention. This study focused on the impact of trophic interactions on bioaugmentation success in two soils with different pollution exposure histories. We inoculated a 13C-labelled pollutant-degrading consortium in these soils and tracked the fate of the labelled biomass through stable isotope probing (SIP) of DNA. We identified active bacterial and eukaryotic inoculum-biomass consumers through amplicon sequencing of 16S rRNA and 18S rRNA genes coupled to a novel enrichment factor calculation.

Results

Inoculation effectively increased PAH removal in the short-term, but not in the long-term polluted soil. A decrease in the relative abundance of the inoculated genera was observed already on day 15 in the long-term polluted soil, while growth of these genera was observed in the short-term polluted soil, indicating establishment of the inoculum. In both soils, eukaryotic genera dominated as early incorporators of 13C-labelled biomass, while bacteria incorporated the labelled biomass at the end of the incubation period, probably through cross-feeding. We also found different successional patterns between the two soils. In the short-term polluted soil, Cercozoa and Fungi genera predominated as early incorporators, whereas Ciliophora, Ochrophyta and Amoebozoa were the predominant genera in the long-term polluted soil.

Conclusion

Our results showed differences in the inoculum establishment and predator community responses, affecting bioaugmentation efficiency. This highlights the need to further study predation effects on inoculum survival to increase the applicability of inoculation-based technologies.
Public perceptions of international genetic information sharing for biomedical research in China: a case study of the social media debate on the article “A Pangenome Reference of 36 Chinese Populations” published in Nature
Authors: Wang Zhangyu , Wang Meng , Du Li
Published: August 2024

Background

The international disclosure of Chinese human genetic data continues to be a contentious issue in China, generating public debates in both traditional and social media channels. Concerns have intensified after Chinese scientists’ research on pangenome data was published in the prestigious journal Nature.

Methods

This study scrutinized microblogs posted on Weibo, a popular Chinese social media site, in the two months immediately following the publication (June 14, 2023–August 21, 2023). Content analysis was conducted to assess the nature of public responses, justifications for positive or negative attitudes, and the users’ overall knowledge of how Chinese human genetic information is regulated and managed in China.

Results

Weibo users displayed contrasting attitudes towards the article’s public disclose of pangenome research data, with 18% positive, 64% negative, and 18% neutral. Positive attitudes came primarily from verified government and media accounts, which praised the publication. In contrast, negative attitudes originated from individual users who were concerned about national security and health risks and often believed that the researchers have betrayed China. The benefits of data sharing highlighted in the commentaries included advancements in disease research and scientific progress. Approximately 16% of the microblogs indicated that Weibo users had misunderstood existing regulations and laws governing data sharing and stewardship.

Conclusions

Based on the predominantly negative public attitudes toward scientific data sharing established by our study, we recommend enhanced outreach by scientists and scientific institutions to increase the public understanding of developments in genetic research, international data sharing, and associated regulations. Additionally, governmental agencies can alleviate public fears and concerns by being more transparent about their security reviews of international collaborative research involving Chinese human genetic data and its cross-border transfer.
Hypomania-Checklist-33: risk stratification and factor structure in a mixed psychiatric adolescent sample
Authors: Gerstenberg Miriam , Smigielski Lukasz , Werling Anna M. , Dimitriades Maria E. , Correll Christoph U. , Walitza Susanne , Angst Jules
Published: August 2024

Background

The 33-item Hypomania Checklist (HCL-33) has been shown to distinguish between adolescent bipolar disorder (BD) and unipolar depression. To investigate the utility of the HCL-33 as a screening tool in routine diagnostics, the frequency and psychopathological characteristics of detected individuals in a mixed psychiatric sample necessitate more examination.

Methods

The HCL-33, Children’s Depression Inventory, Beck’s Anxiety Inventory, and Strengths and Difficulties Questionnaire were completed by 285 children and adolescents (12–18 years) in a mixed psychiatric sample. Applying the proposed HCL-33 cut-off score of ≥ 18, individuals with depressive symptoms were divided into at-risk or not at-risk for BD groups. The factorial structure, sum and factor score correlations with psychopathology, and impact on daily functioning were assessed.

Results

20.6% of the sample met at-risk criteria for BD. These individuals (n = 55) were older, more anxious, and showed more conduct problems vs the not at-risk group (n = 107). A two- and a three-factor model were pursued with the same Factor 1 (“active-elated”). Factor 2 (“risk-taking/irritable”) was separated into 2a (“irritable-erratic”) and 2b (“outgoing-disinhibited”) in the three-factor model. Whereas higher Factor 2 and 2a scores correlated with a broad range of more severe symptomatology (i.e., depression, anxiety, hyperactivity), higher Factor 1 and 2b scores correlated with more emotional and conduct problems, respectively. 51.7% of the sample reported a negative impact from hypomanic symptoms on daily functioning.

Limitations

Cross-sectional design and data collection in a single mental health service.

Conclusions

The HCL-33 may be a useful tool to improve diagnostics, especially in adolescents with depressive symptoms additionally presenting with anxious symptoms and conduct problems.
Genome-wide CRISPR-Cas9 knockout screens identify DNMT1 as a druggable dependency in sonic hedgehog medulloblastoma
Authors: Tsiami Foteini , Lago Chiara , Pozza Noemi , Piccioni Federica , Zhao Xuesong , Lülsberg Fabienne , Root David E. , Tiberi Luca , Kool Marcel , Schittenhelm Jens , Bandopadhayay Pratiti , Segal Rosalind A. , Tabatabai Ghazaleh , Merk Daniel J.
Published: August 2024

Sonic hedgehog subgroup of medulloblastoma (SHH-MB) is characterized by aberrant activation of the SHH signaling pathway. An inhibition of the positive SHH regulator Smoothened (SMO) has demonstrated promising clinical efficacy. Yet, primary and acquired resistance to SMO inhibitors limit their efficacy. An understanding of underlying molecular mechanisms of resistance to therapy is warranted to bridge this unmet need. Here, we make use of genome-wide CRISPR-Cas9 knockout screens in murine SMB21 and human DAOY cells, in order to unravel genetic dependencies and drug-related genetic interactors that could serve as alternative therapeutic targets for SHH-MB. Our screens reinforce SMB21 cells as a faithful model system for SHH-MB, as opposed to DAOY cells, and identify members of the epigenetic machinery including DNA methyltransferase 1 (DNMT1) as druggable targets in SHH-dependent tumors. We show that Dnmt1 plays a crucial role in normal murine cerebellar development and is required for SHH-MB growth in vivo. Additionally, DNMT1 pharmacological inhibition alone and in combination with SMO inhibition effectively inhibits tumor growth in murine and human SHH-MB cell models and prolongs survival of SHH-MB mouse models by inhibiting SHH signaling output downstream of SMO. In conclusion, our data highlight the potential of inhibiting epigenetic regulators as a novel therapeutic avenue in SMO-inhibitor sensitive as well as resistant SHH-MBs.
The Changsha historic urban area: a study on the evolution characteristics and influencing factors of the connectivity of construction land
Authors: Zhang Boyang , Fan Jinyu , Zhang Piao , Shen Sha , Ren Yangming
Published: August 2024

This study aims to understand the connectivity characteristics of construction land during the spatial evolution of historic urban areas. The complex network analysis method is employed to examine the evolution of the spatial structure of construction land in the four periods of the Changsha historic urban area. The results indicate that the spatial network morphology of construction land follows a repeated development pattern resembling a cluster–mother–child relationship. Additionally, the vulnerability in the evolution of land use spatial relationships is very low, while the overall stability of the land use network structure decreases. The spatial equilibrium of land use shows a downwards trend, the accessibility of land where existing cultural relics and historic sites are located is generally moderate to low, and some plots require improvement. In the evolution of connectivity in the construction land of historic urban areas, the main development challenges are the uneven growth caused by imbalanced land value influenced by capital and the need to balance the preservation of land use patterns with improved accessibility to cultural relics and historic sites. Therefore, it is highly important to dynamically detect and optimize the network structure of construction land to protect and develop historic urban areas.
Young people’s trust in institutions, civic knowledge and their dispositions toward civic engagement
Authors: Schulz Wolfram
Published: August 2024

Recent years have witnessed signs of increasing political instability in democratic countries as well as growing alienation from civic institutions and processes among citizens, especially among young people. Within the context of civic and citizenship education, it is important to review such phenomena and study their extent among young people as well as the factors that have the potential of promoting different forms of citizenship engagement. Using data from the International Civic and Citizenship Education Study (ICCS) 2016 and 2009, this article provides insights into the expectations of young people to actively engage as citizens in the future and what influences these expectations, with a primary focus on the role of civic knowledge and trust in civic institutions.

Results from ICCS 2009 and 2016 show that while large majorities among young people expected to vote in elections, only relatively few found it likely to be more actively involved in political action. Except for engagement in illegal protest, young people’s expected participation in general appeared to be positively related to trust. However, associations with civic knowledge were more differentiated. Trust and civic knowledge tended to have negative correlations in countries with higher levels of perceived corruption, while a different association became apparent in democracies with more transparent institutions. Civic knowledge was consistently positively related to anticipated voting while it was negatively related to expected illegal protest. More knowledgeable students were also less inclined to consider active (conventional) forms of political participation in the future.
Precursory seismic quiescence of major earthquakes along the Sagaing fault zone, central Myanmar: application of the pattern informatics technique
Authors: Traitangwong Premwadee , Khamsiri Sutthikan , Pailoplee Santi
Published: August 2024

In this study, the precursory seismic activity before a major earthquake was investigated by using the Pattern Informatics (PI) algorithm along the Sagaing fault zone (SFZ), Central Myanmar. After improving the earthquake catalog, the completeness of seismicity data with Mw ≥ 3.6 reported during 1980–2020 was used in retrospective testing to find the suitable parameters of the PI algorithm. According to the retrospective test with 6 cases of different forecast period times related to Mw ≥ 5.0 earthquakes, including verification using the relative operating characteristics (ROC) diagram, the characteristic parameters of both time intervals (change time and forecast time window) = 10 years and target forecast earthquake magnitude Mw ≥ 5.0 are suitable parameters for PI investigation along the SFZ. Therefore, these parameters were applied with the most up-to-date seismic dataset to evaluate the prospective areas of upcoming major earthquakes. The results reveal that the Myitkyina and the vicinity of Naypyidaw might be at risk of a major earthquake in the future. Therefore, effective earthquake mitigation plans should be urgently arranged.
Biodegradation: the best solution to the world problem of discarded polymers
Authors: Wu Jun , Wang Jia , Zeng Yicheng , Sun Xinxiao , Yuan Qipeng , Liu Ling , Shen Xiaolin
Published: August 2024

The widespread use of polymers has made our lives increasingly convenient by offering a more convenient and dependable material. However, the challenge of efficiently decomposing these materials has resulted in a surge of polymer waste, posing environment and health risk. Currently, landfill and incineration treatment approaches have notable shortcomings, prompting a shift towards more eco-friendly and sustainable biodegradation approaches. Biodegradation primarily relies on microorganisms, with research focusing on both solitary bacterial strain and multi-strain communities for polymer biodegradation. Furthermore, directed evolution and rational design of enzyme have significantly contributed to the polymer biodegradation process. However, previous reviews often undervaluing the role of multi-strain communities. In this review, we assess the current state of these three significant fields of research, provide practical solutions to issues with polymer biodegradation, and outline potential future directions for the subject. Ultimately, biodegradation, whether facilitated by single bacteria, multi-strain communities, or engineered enzymes, now represents the most effective method for managing waste polymers.

Graphical Abstract
Appendiceal goblet cell adenocarcinoma with perineural invasion extending into the ileocecal lesion
Authors: Hosokawa Yuka , Fujiyoshi Sunao , Imaizumi Ken , Shibata Kengo , Ichikawa Nobuki , Yoshida Tadashi , Homma Shigenori , Kudo Takeaki , Okazaki Nanase , Tomaru Utano , Taketomi Akinobu
Published: August 2024

Background

Appendiceal goblet cell adenocarcinoma (GCA) is a rare subtype of primary appendiceal adenocarcinoma with an incidence of 1–5 per 10,000,000 people per year. Appendiceal tumors are often diagnosed after appendectomy for acute appendicitis. Notably, however, there is currently no standard treatment strategy for GCA, including additional resection. We report a case of appendiceal GCA with perineural extension into the cecum, in which ileal resection was considered effective.

Case presentation

A 41-year-old man was diagnosed with acute appendicitis and underwent appendectomy. Histopathological findings revealed GCA (T3, Pn1). He was referred to our hospital for additional resection. Preoperative examination indicated a diagnosis of GCA cT3N0M0. Laparoscopic ileocecal resection and D3 lymph node dissection were performed 2 months after initial appendectomy. The patient had a good postoperative course and was discharged 8 days after surgery. Histopathological findings showed a GCA invading the cecum, despite an intact appendiceal stump, no lymph node metastasis, no vascular invasion, and no horizontal extension into the submucosa. Direct invasion of the tumor through the serosa was not observed, but perineural extension was conspicuous in the cecum, suggesting that the GCA extended into the cecum via perineural invasion. The resection margins were negative. The patient has survived free of recurrence for a year after ileocecal resection.

Conclusions

The current patient was diagnosed with appendiceal GCA following appendectomy for acute appendicitis. Despite intact of appendiceal stump and no evidence of lymph node or distant metastasis, he underwent laparoscopic ileocecal resection and D3 lymph node dissection 2 months after initial appendectomy, with a favorable outcome. Despite the detection of perineural invasion, the patient declined adjuvant therapy. This case suggests that extensive resection may be required in patients with appendiceal GCA, but the role of adjuvant therapy remains unclear.
Impact of a community-based participatory research project with underserved communities at risk for hepatitis C virus in Ho Chi Minh City, Vietnam: an evaluation study
Authors: Thao My Nguyen Le , Quoc Giang Nguyen , An My Do Thi , Minh Hieu Nguyen , Hong Son Pham , Thai Anh Hoang , Thi Phung Than , Thanh Vy Nguyen Thuy , Thi Ngoc Tran , Minh Thuan Nguyen , Flower Barnaby , Cooke Graham S. , Chambers Mary , Van Nuil Jennifer Ilo
Published: August 2024

Background

Participatory approaches have become a widely applied research approach. Despite their popularity, there are many challenges associated with the evaluation of participatory projects. Here we describe an evaluation of a community-based participatory research study of underserved communities in Ho Chi Minh City (HCMC), Vietnam at risk for hepatitis C virus. The goals of our evaluation were to explore the main benefits and challenges of implementing and participating in a participatory study and to describe study impacts.

Methods

We conducted two meetings with leaders and members of the participating groups followed by in-depth interviews with 10 participants. We then held a dissemination meeting with over 70 participants, including the representatives of each group, researchers from non-governmental organizations (community-based, national and international), and govenrment officials from the Vietnam Ministry of Health and the Department of Health of HCMC.

Results

Results include four categories where we describe first the participatory impacts, followed by the collaborative impacts. Then we describe the benefits and challenges of creating and belonging to one of the groups, from members’ and leaders’ points of view. Finally, we describe the key suggestions that participants provided for future research.

Conclusion

In conclusion, the evaluation approach led to both a research reflection on the ‘success’ of the project and enabled participants themselves to reflect on the outcomes and benefits of the study from their point of view.
Metamaterial design for aortic aneurysm simulation using 3D printing
Authors: Sakai Arthur K. F. , Cestari Ismar N. , de Sales Eraldo , Mazzetto Marcelo , Cestari Idágene A.
Published: August 2024

Introduction

The use of three-dimensional (3D) printed anatomic models is steadily increasing in research and as a tool for clinical decision-making. The mechanical properties of polymers and metamaterials were investigated to evaluate their application in mimicking the biomechanics of the aortic vessel wall.

Methodology

Uniaxial tensile tests were performed to determine the elastic modulus, mechanical stress, and strain of 3D printed samples. We used a combination of materials, designed to mimic biological tissues’ properties, the rigid VeroTM family, and the flexible Agilus30™. Metamaterials were designed by tessellating unit cells that were used as lattice-reinforcement to tune their mechanical properties. The lattice-reinforcements were based on two groups of patterns, mainly responding to the movement between links/threads (chain and knitted) or to deformation (origami and diamond crystal). The mechanical properties of the printed materials were compared with the characteristics of healthy and aneurysmal aortas.

Results

Uniaxial tensile tests showed that the use of a lattice-reinforcement increased rigidity and may increase the maximum stress generated. The pattern and material of the lattice-reinforcement may increase or reduce the strain at maximum stress, which is also affected by the base material used. Printed samples showed max stress ranging from 0.39 ± 0.01 MPa to 0.88 ± 0.02 MPa, and strain at max stress ranging from 70.44 ± 0.86% to 158.21 ± 8.99%. An example of an application was created by inserting a metamaterial designed as a lattice-reinforcement on a model of the aorta to simulate an abdominal aortic aneurysm.

Conclusion

The maximum stresses obtained with the printed models were similar to those of aortic tissue reported in the literature, despite the fact that the models did not perfectly reproduce the biological tissue behavior.
Development and validation of a rapid loop-mediated isothermal amplification assay for the detection of Chrysomyxa and characterization of Chrysomyxa woroninii overwintering on Picea in China
Authors: Yu Wan Ting , Wang Xin , Yin Tan , Tsui Clement Kin-Ming , You Chong Juan
Published: August 2024

Chrysomyxa rusts cause significant damage to spruce in both natural forests and plantations. Particularly, Three Chrysomyxa species, Chrysomyxa deformans, Chrysomyxa qilianensis, and Chrysomyxa rhododendri, listed as National Forest Dangerous Pests in China, have severely affected many economically and ecologically important spruce native species in China. Also, Chrysomyxa arctostaphyli, an important plant quarantine fungus, causes a damaging broom rust disease on spruce. Therefore, rapid, and efficient detection tools are urgently needed for proper rust disease detection and management. In this study, a sensitive, genus-specific loop-mediated isothermal amplification (LAMP) assay targeting the ITS-28S rRNA region was developed to detect the presence of Chrysomyxa in spruce needle and bud samples. After optimization and validation, the LAMP assay was found to be sensitive to detect as low as 5.2 fg/µL DNA, making it suitable for rapid on-site testing for rust infection. The assay was also specific to Chrysomyxa species, with no positive signals from other rust genus/species. The application of LAMP in the early detection of rust infections in spruce needles and buds was investigated, and spatial colonization profiles as well as the means of overwintering of Chrysomyxa woroninii in infected buds and branches were verified using the LAMP assay. This LAMP detection method will facilitate further studies on the characteristics of the life cycle and inoculation of other systemic rusts.
Role of diffusion tensor imaging of extra ocular muscles and orbital fat in Graves’s ophthalmopathy and relation to disease activity
Authors: Hussein Manar Mansour , Mohamed Mohamed Ghonem , Mousa Amany Abdel Hamid , Baiomy Azza Abd El Baky , Abdel Razek Ahmed Abd El Khalek , El Ghani Mohamed Roshdi Abd
Published: August 2024

Background

Graves’ ophthalmopathy (GO) is one of the most common autoimmune inflammatory disorders affecting the orbit that characterized by swelling of extra ocular muscles (EOMs) and expansion of the orbital fat. Diffusion tensor imaging (DTI) could assess the microstructural integrity of tissue. We aimed at this study to assess the role of DTI in the evaluation of EOMs and orbital fat in GO and identify the relationship with disease activity.

Results

Case–control study included 40 patients diagnosed as Graves’ disease (20 active and 20 inactive) and 10 health control subjects underwent DTI. Low fraction anisotropy (FA) and high mean diffusivity (MD) of inferior rectus (IR), medial rectus (MR) and orbital fat in GO versus healthy control (HC), while high FA and high MD in active group versus inactive group. In order to differentiate between GO and HC; FA cutoff point of IR, MR& orbital fat were 0.46, 0.45 and 0.26 with sensitivity 98.8%,98.8% and 93.8% and specificity 95.0%, 95.0% and 85%, respectively. MD cutoff point for IR, MR and orbital fat 1.24, 1.27 and 1.275 with sensitivity 97.5%, 98.8% and 98.8% and specificity 95.0%, 95% and 95%, respectively. To differentiate between active and inactive GO; FA cutoff point of IR, MR and orbital fat were 0.35, 0.36 and 0.22 respectively with sensitivity 80.0%, 82.5% and 72.5% and specificity 95.0%, 85.0% and 65.0%, respectively. MD cutoff point for IR, MR and orbital fat were 1.58, 1.63 and 1.54 respectively with sensitivity 90.0%, 97.5% and 85.0%, and specificity 90.0%, 80.0% and 62.5%, respectively.

Conclusions

DTI parameters (FA and MD) of EOMs and orbital fat are considered as crucial radiological biomarkers for diagnosis of GO and could quantitatively differentiate active form inactive disease.
Specifying behavioural and strategy components of de-implementation efforts targeting low-value prescribing practices in secondary health care
Authors: Dunsmore Jennifer , Duncan Eilidh , MacLennan Sara , N’Dow James , MacLennan Steven
Published: August 2024

Background

/Aims

De-implementation, including the removal or reduction of unnecessary or inappropriate prescribing, is crucial to ensure patients receive appropriate evidence-based health care. The utilization of de-implementation efforts is contingent on the quality of strategy reporting. To further understand effective ways to de-implement medical practices, specification of behavioural targets and components of de-implementation strategies are required. This paper aims to critically analyse how well the behavioural targets and strategy components, in studies that focused on de-implementing unnecessary or inappropriate prescribing in secondary healthcare settings, were reported.

Methods

A supplementary analysis of studies included in a recently published review of de-implementation studies was conducted. Article text was coded verbatim to two established specification frameworks. Behavioural components were coded deductively to the five elements of the Action, Actor, Context, Target, Time (AACTT) framework. Strategy components were mapped to the nine elements of the Proctor’s ‘measuring implementation strategies’ framework.

Results

The behavioural components of low-value prescribing, as coded to the AACTT framework, were generally specified well. However, the Actor and Time components were often vague or not well reported. Specification of strategy components, as coded to the Proctor framework, were less well reported. Proctor’s Actor, Action target: specifying targets, Dose and Justification elements were not well reported or varied in the amount of detail offered. We also offer suggestions of additional specifications to make, such as the ‘interactions’ participants have with a strategy.

Conclusion

Specification of behavioural targets and components of de-implementation strategies for prescribing practices can be accommodated by the AACTT and Proctor frameworks when used in conjunction. These essential details are required to understand, replicate and successfully de-implement unnecessary or inappropriate prescribing. In general, standardisation in the reporting quality of these components is required to replicate any de-implementation efforts.

Trial registration

Not registered.
The remote revolution: assessing the impact of working from home on finance professionals
Authors: Al Mohamed Alaa Alden , Al Mohamed Sobhi , Alebrahem Morhaf
Published: August 2024

The aim of this study is to investigate how remote work affects job performance. It suggests that factors such as the work environment, employee productivity, and work-life balance play a role in mediating this impact. The study also explores how remote work influences employee performance through these variables. The findings of this research have practical implications for businesses looking to evaluate the effectiveness of their remote work policies, especially during the ongoing coronavirus crisis. One distinctive feature of this study is its questionnaire, which has been specifically designed to capture the effects of COVID-19. Data were collected through an online survey distributed to workers in Syria. The survey, which utilized a Likert scale, was sent via email to around 2650 employees and was also shared on social media platforms. A total of 300 respondents took part in the survey. To address the research questions, structural equation modelling was employed in this study. The results indicated that remote work resulted in increased enjoyment, satisfaction, and motivation among employees, ultimately improving job performance. It is worth noting that while this research focuses on examining these benefits within the context of Syria, there is potential for external validity among other countries affected by the COVID-19 pandemic.
Neurofibromatosis 1-associated diffuse lung disease in an elderly man—a case report
Authors: Sarkar Subho , Girija Aswathy , Panigrahi Manoj Kumar
Published: August 2024

Background

Neurofibromatosis 1 is a form of phacomatosis or neurocutaneous disease inherited as an autosomal dominant disease. Thoracic involvement is rare and involves the lung parenchyma, mediastinum, and thoracic cage, including ribs and the spine. Lung parenchymal involvement includes airspace abnormalities like cysts, bullae, and emphysema with an upper lobe predominance and interstitial abnormality in the form of reticulations and fibrosis in the lower lobes. The structural abnormality of the lung resembles numerous other diseases. Hence, properly identifying and recognizing neurofibromatosis 1-associated diffuse lung disease (NF-1 DLD) is crucial in avoiding misdiagnosis. NF1-DLD is associated with many complications like pulmonary hypertension, lung malignancy, aspergilloma, secondary bacterial infections, and pneumothorax.

Case presentation

An elderly male with neurofibromatosis type-1 presented with breathlessness, cough, and mucopurulent expectoration and was found to have diffuse involvement of the lung parenchyma involving cysts, bullae, emphysema, fibrosis, and traction bronchiectasis. He was managed conservatively, controlling infection and optimizing respiratory symptoms.

Conclusion

Neurofibromatosis-associated diffuse lung disease is a rare disorder. There is no definitive treatment that can reverse the pulmonary lesions. However, early diagnosis will help plan effective preventive measures and avoid complications. We present this case to increase awareness regarding the various pulmonary manifestations of neurofibromatosis.
The state-led approach to industrial heritage in China’s mega-events: capital accumulation, urban regeneration, and heritage preservation
Authors: Zhang Mengke
Published: August 2024

This paper employs a comparative analysis to investigate the state-led use of industrial heritage in major Chinese mega-events, delving into the three cases of the Guangzhou Asian Games, the Shanghai Expo, and the Beijing Winter Olympics. Examining the evolving practices led by Chinese governments reveals unique pathways for industrial heritage and showcases its diverse roles in economic development and societal transformation. The three cases illustrate the nuanced dynamics between market forces and state interventions, emphasising the importance of strategic planning and long-term considerations in mega-event-induced heritage practices. Mega-events serve as catalysts for urban regeneration, allowing governments to allocate substantial resources to conserve and repurpose industrial heritage. However, the current paper contends that the sustained benefits of industrial heritage hinge on thoughtful planning for long-term economic and social sustainability, emphasising the need to constrain a focus on short-term gains through land revenue. These reflections contribute to a nuanced understanding of the intricate interplay between heritage preservation, economic development, and sustainable urban planning in the context of China’s mega-events.
Perspectives on physician-assisted suicide in mental healthcare: results of a survey of physicians and medical students
Authors: Reichel Rebecca , Adam Sophia Helen , Ehni Hans-Jörg , Junne Florian , Herrmann-Werner Anne , Fallgatter Andreas J. , Zipfel Stephan , Erschens Rebecca
Published: August 2024

Background

Physician-assisted suicide (PAS) is typically associated with serious physical illnesses that are prevalent in palliative care. However, individuals with mental illnesses may also experience such severity that life becomes intolerable. In February 2020, the previous German law prohibiting PAS was repealed. Patients with severe mental illnesses are increasingly likely to approach physicians with requests for PAS.

Aims

To explore the ethical and moral perspectives of medical students and physicians when making individual decisions regarding PAS.

Method

An anonymised digital survey was conducted among medical students and physicians in Germany. Participants were presented with a case vignette of a chronically depressed patient requesting PAS. Participants decided on PAS provision and assessed theoretical arguments. We employed generalised ordinal regression and qualitative analysis for data interpretation.

Results

A total of N = 1478 participants completed the survey. Of these, n = 470 (32%) stated that they would refuse the request, whereas n = 582 (39%) would probably refuse, n = 375 (25%) would probably agree and n = 57 (4%) would definitely agree. Patient-centred arguments such as the right to self-determination increased the likelihood of consent. Concerns that PAS for chronically depressed patients might erode trust in the medical profession resulted in a decreased willingness to provide PAS.

Conclusions

Participants displayed relatively low willingness to consider PAS in the case of a chronically depressed patient. This study highlights the substantial influence of theoretical medical-ethical arguments and the broader public discourse, underscoring the necessity of an ethical discussion on PAS for mental illnesses.
Stage 2 Registered Report Personal factors and group creative outcomes: A correlational meta-analysis
Authors: Fillon Adrien A. , Girandola Fabien , Bonnardel Nathalie , Kenworthy Jared B. , Souchet Lionel
Published: August 2024

Previous research has indicated that individual differences play a role in group creativity. Group creativity activities have different outcomes, leading to numerous ways to assess the effectiveness of these creative activities. To date, no meta-analysis has been performed on the relationship between the outcomes of the creative activity and personal factors of the group members. In this Registered Report, we conducted a meta-analysis (n = 11, k = 72) on the relationship between personal factors and group creativity outcomes. We found weak support for a positive correlation between self-efficacy and group creativity outcomes, between r = .04 and r = .67. We found weak support for a moderation effect of time constraint, with stronger relationships for conditions limited to 20 minutes as opposed to 10 minutes. Finally, we found that only a few studies could be included in the meta-analysis, because many studies (1) did not directly measure creativity, or (2) measured other, less common personal factors. We call for a more systematic and direct approach to measuring creativity and an improvement of open science practices in the field. Data and analysis can be found at https://osf.io/xwph9.
Differential physical interactions of wild-type and S59L mutant CHCHD10 with mitochondrial proteases
Authors: Oh Seungjae , Kim Nam Chul
Published: August 2024

Background CHCHD10 is a small mitochondrial protein with a C-terminal coiled-coil-helix–coiled-coil-helix domain. The N-terminal region of CHCHD10 is mostly intrinsically disordered. Therefore, CHCHD10 has no catalytic activity other than protein-protein interactions through the CHCH domain or intrinsically disordered region. The S59L mutation in CHCHD10 has been identified as a genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. However, the disease-causing mechanisms of CHCHD10S59L are not yet fully understood. Our previous study showed that CHCHD10S59L induces PINK1 and Parkin accumulation. PINK1 stabilization in the mitochondria is dependent on proteolytic processing by mitochondrial proteases. It has also been reported that mutant CHCHD10 disrupts protein homeostasis within mitochondria. Therefore, we hypothesized that CHCHD10S59L physically interacts with mitochondrial proteases during the disease pathogenesis. Methods To test this hypothesis, we performed co-immunoprecipitation using transiently transfected wild-type and mutant S59L CHCHD10 in HeLa cells. We employed a dithiobis (succinimidyl propionate) cross-linker to detect transient physical interactions. Results We expected that CHCHD10S59L may activate mitochondrial protease processing or expression and that it interacts with more diverse mitochondrial proteases than the wild type. In general, however, there was no difference in the expression and processing levels of mitochondrial proteases and the proteases that interact with wild-type and CHCHD10S59L. LonP1 degrading unfolded proteins in the mitochondrial matrix was the major proteases that can bind to wild-type CHCHD10 and CHCHD10S59L. LonP1 and HtrA2 were significantly less strongly bound to CHCHD10S59L. Conclusions This result can be interpreted in many different ways, including the regulatory role of CHCHD10 in mitochondrial proteases. However, more precise biochemical and cell biological investigations are required to determine the role of CHCHD10 in the activity of mitochondrial proteases, mechanism of PINK1 stabilization, and disruption of mitochondrial proteostasis.
Rituals as Nature-Based Governance of reciprocity between people and nature
Authors: Herrmann-Pillath Carsten
Published: August 2024

The conventional approach to environmental governance, based on institutions, regulations, and interventions, has failed to stop the current ecological catastrophe. I suggest a radical alternative: Ritual as the core mode of ‘nature-based governance’ (NBG) that enacts deep and comprehensive reciprocity between people and nature. NBG grounds governance mechanisms in embodied more-than-human practices with normative force. I build on theories of embodiment to suggest a general concept of ritual that is inspired by but generalizes over Indigenous thought and is informed by East Asian ideas about ritual as the pivot of social order. Further, the embodiment framework recognises ritual as a kind of action humans and non-humans share as living beings. Therefore, rituals can be harnessed in workable governance mechanisms to create and sustain communities of multi-species cohabitation. I distinguish between two basic types of reciprocity corresponding to two types of governance: Disembodied reciprocity enacted by conventional human-only governance schemes and embodied reciprocity enacted by NBG. Embodied reciprocity creates relationality of people and nature. Equipped with these theoretical insights, I suggest practical applications in the context of NBG of Nature-based solutions, discussing three stylized models. These are the formation of urban multi-species communities in urban gardening and urban forests, the commoning of ecosystem services of animal populations in wildfire protection, and reconceptualizing eco-compensation as a reciprocal ritual of gift-giving,
What is the IPCC’s assessment style and what shaped it?
Authors: Târziu Gabriel
Published: August 2024

The Intergovernmental Panel on Climate Change (IPCC) is one of the best-known global expert organizations. Its main objective is to supply policymakers with policy-relevant recent scientific information about climate change. The way in which the IPCC is obtaining this information is called an assessment. But assessments can be performed in a wide variety of ways. An important step, then, in understanding what this important organization does and why, is to figure out what characterizes the particular type of assessment it performs. The main objective of this paper is to contribute to the literature dedicated to understanding the work of IPCC by outlining the characteristics of the IPCC's assessment style and providing an in-depth analysis of the factors that have contributed to its development. As it will be argued here, understanding the climate-scientific-specific obstacles that had to be overcome by the IPCC in the process of pursuing its objectives is crucial for understanding why the IPCC is performing the type of assessment that it does and also for understanding some of the most important controversies associated with it.
The genome sequence of the Broad-barred Knot-horn, Acrobasis consociella (Hübner, 1813)
Authors: Boyes Douglas , Crowley Liam C. , Hutchinson Finley , Wawman Denise C. ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life Management, Samples and Laboratory team,   Wellcome Sanger Institute Scientific Operations: Sequencing Operations,   Wellcome Sanger Institute Tree of Life Core Informatics team,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: August 2024

We present a genome assembly from one female Acrobasis consociella (the Broad-barred Knot-horn; Arthropoda; Insecta; Lepidoptera; Pyralidae). The genome sequence is 598.4 megabases in span. Most of the assembly is scaffolded into 31 chromosomal pseudomolecules, including the Z and W sex chromosomes. The mitochondrial genome has also been assembled and is 15.22 kilobases in length.