bluuebunny/crossref_metadata_2025 huggingface dataset:
China – EU’s “Significant Other”?
Authors: Milanov Martin
Published: November 2021

Following the idea of the “other” in the work of Ernesto Laclau and the perspective of post-foundational discourse analysis, the study focusses on Chinese strategical internal and external pre- and post-Covid-19 political specifics and policies and how they interact (or contradict) with the “European” vision of the world and most importantly itself. As Laclau says, “the notion of “constitutive outside” emphasizes the always present possibility that differential relationship between an entity and its “constitutive outside” turns into antagonism.” For more than three decades, the EC/EU has been steadily building up its foreign relations architecture and has proven its desire to project its ideals and values worldwide. However, during the same period, after “the century of humiliation,” China has also reached a point in its history where it wants to see the world according to its national interests and views. This work attempts to analyze some key features inherent to both the EU and China, such as strategies, relation with other countries, typical governmental architecture, and some aspects of identity, which could help in better understanding the possible contradictions and areas of cooperation in their way of conceptualizing themselves as key players on the world stage. This will reflect the need for greater European civic awareness in the upcoming decades, as suggested by the author.
The EU Delegation in Saudi Arabia and the GCC: Communication, Visibility and Culture
Authors: Gołębiowski Daniel
Published: November 2021

The paper examines communication and visibility (C&V) aspect in the operations of the EU Delegation in Saudi Arabia and the GFA Consulting Group. The author assumes that properly designed communication using adequate contents may significantly affect the EU external relations. To verify this statement, the twofold approach was used. First, through the lens of Soft Power and EU actorness, it looks into the theoretical dimension of the international relations and its possible links with communication process. Second, drawing on existing internal EU documents (Communication and Visibility in EU-financed External Actions – Requirements for Implementing Partners 2018 by the EU Delegation in Saudi Arabia, and Information and Communication Handbook for EU Delegations in the Third Countries and International Organizations, published in 20122) the paper offers analytical framework to explore the qualitative and quantitative nature of the online communication undertaken in social media platform both by the EU Delegation in Saudi Arabia and the GFA.
The management of suspected scaphoid fractures in the UK: a national cross-sectional study
Authors: Dean Benjamin J. F. ,   *On behalf of the SUSPECT study group
Published: November 2021

Aims

Current National Institute for Health and Clinical Excellence (NICE) guidance advises that MRI direct from the emergency department (ED) should be considered for suspected scaphoid fractures. This study reports the current management of suspected scaphoid fractures in the UK and assesses adherence with NICE guidance.

Methods

This national cross-sectional study was carried out at 87 NHS centres in the UK involving 122 EDs and 184 minor injuries units (MIUs). The primary outcome was availability of MRI imaging direct from the ED. We also report the specifics of patient management pathways for suspected scaphoid fractures in EDs, MIUs, and orthopaedic services. Overall, 62 of 87 centres (71%) had a guideline for the management of suspected scaphoid fractures.

Results

A total of 11 of 87 centres (13%) had MRI directly available from the ED. Overall, 14 centres (17%) used cross-sectional imaging direct from the ED: MRI in 11 (13%), CT in three (3%), and a mixture of MRI/CT in one (1%). Four centres (6%) used cross-sectional imaging direct from the MIU: MRI in three (4%) and CT in two (2%). Of 87 centres’ orthopaedic specialist services, 74 (85%) obtained repeat radiographs, while the most common form of definitive imaging used was MRI in 55 (63%), CT in 16 (19%), mixture of MRI/CT in three (3%), and radiographs in 11 (13%).

Conclusion

Only a small minority of centres currently offer MRI directly from the ED for patients with a suspected scaphoid fracture. Further research is needed to investigate the facilitators and barriers to the implementation of NICE guidance. Cite this article: Bone Jt Open 2021;2(11):997–1003.
Accurate estimation of camera response function for high dynamic range measurement
Authors: Li Ji , Guan Jingtian , Wang Yukun , Chen Xiaobo , Xi Juntong
Published: November 2021

A high dynamic range surface has large reflectivity variations and measuring it with a structured light technique could cause pixel saturation that will seriously degrade the measurement accuracy. Accurate identification of saturated pixels will significantly improve the measurement accuracy. This paper introduces an accurate estimation approach to the camera response function (CRF) for high dynamic range measurement and proposes a method that uses the estimated CRF to identify the saturated pixels in captured images. We perform experiments using the proposed saturation identification method and the other existing methods to compare both the saturation identification accuracy and measurement accuracy. The experiment results verify both the accuracy and suitability of the proposed method.
Microstructured optical fiber filled with glycerin for temperature measurement based on dispersive wave and soliton
Authors: Cheng Tonglei , Chen Xiaoyu , Yan Xin , Zhang Xuenan , Wang Fang , Suzuki Takenobu , Ohishi Yasutake
Published: November 2021

A nonlinear temperature sensor was proposed drawing on dispersive wave (DW) and soliton in an in-house made silica microstructured optical fiber (MOF). Glycerin with high thermo-optical coefficient was filled into the MOF air holes as the thermal medium. Using a 1050 nm femtosecond laser as the pump source, DW and soliton were experimentally and theoretically explored for temperature sensing by detecting their central wavelength shift of 3-dB bandwidth. The results showed that the higher the average pump power, the higher the temperature sensitivity of DW and soliton. When the DW blue-shifted relative to the soliton, the temperature sensitivity of DW was higher than that of soliton, and the experimental maximum values were 0.928 nm/℃ (DW) and -0.923 nm/℃ (soliton). Our work explored the nonlinear phenomenon for optical fiber-based sensing technology and verified that both DW and soliton can be used to realize temperature sensors of high sensitivity and good mechanical strength. The sensing characteristic difference of DW and soliton revealed in this work might provide a new way for solving the cross-sensitivity of dual-parameter sensing in biological engineering, disease detection and environmental monitoring without introducing extra structural complexity.
Image-enhanced single-pixel imaging using fractional calculus
Authors: Zhang Xiao , Li Rui , Hong Jiaying , Zhou Xi , Xin Nian , Li Qin
Published: November 2021

Recent years, image enhancement for single-pixel imaging has developed
rapidly and provides an image-free way for extracting image
information. However, the conventional image enhancement approaches
for single-pixel imaging are still based on the discontinuously
adjustable operations such as integer-order derivatives, which are
frequently used in edge detection but sensitive to the image noise.
Therefore, how to balance between two conflicting demands, i.e. edge
detection and noise suppression, is a new challenge. To address this
issue, we introduce arbitrary-order fractional operations into
single-pixel imaging. In experiment, the proposed technique has the
capacity to detect image edges with high quality. Compared with
integer-order derivative method which amplifies noise significantly
while extracting edges, it offers a nice tradeoff between image SNR
and performance of edge enhancement. In addition, it also shows good
performance of image smoothing and improvement of image quality, if
fractional order is negative. The proposed technique provides the
adjustable fractional order as a new degree of freedom for edge
extraction and image de-noising and therefore makes up for the
shortcomings of traditional method for image enhancement.
Realizing mutual occlusion in a wide field-of-view for optical see-through augmented reality displays based on a paired-ellipsoidal-mirror structure
Authors: Zhang Yan , Hu Xiaodan , Kiyokawa Kiyoshi , Isoyama Naoya , Uchiyama Hideaki , Hua Hong
Published: November 2021

Mutual occlusion is an essential feature for augmented reality (AR) displays for allowing the virtual content to be clearly perceived under an excessively illuminated environment. Although a few works have been done to facilitate the performance of occlusion-capable optical see-through augmented reality (OC-OST-AR) displays, the realization of mutual occlusion in a wide field-of-view (FOV) is still challenging. Divergent from typical hard-edge occlusion and soft edge-occlusion designs, we propose the paired-ellipsoidal-mirror (PEM) structure. The proposed system is allowed to support either hard-edge occlusion or enhanced soft-edge occlusion in a wide FOV by optionally fixing a spatial light modulator (SLM) before the entrance pupil or at an inner focal plane. The numerical aperture (NA) of the system is efficiently increased by the combination of paired ellipsoidal mirror imaging and aperture stop restriction. With proof-of-concept prototypes built, virtual display in a FOV of H160°×V74° and mutual occlusion in a FOV of H122°×V74° are demonstrated with a basic design, respectively. Furthermore, a mixed FOV of H95.3°×V52.9° is demonstrated by an optimized design with vertical parallax reduction and virtual display improvement.
Topological charge of two parallel Laguerre-Gaussian beams
Authors: Kotlyar Victor V. , Kovalev Alexey A. , Amiri Pouria , Soltani Peyman , Rasouli Saifollah
Published: November 2021

We analytically, numerically, and experimentally determine a topological charge (TC) of the sum of two axisymmetric off-axis Laguerre-Gaussian (LG) beams with the indices (0, m) and (0, n). In particular, we find that at m = n, the combined beam has TC = n, which suggests that the sum of two identical off-axis LG beams has the TC of an individual constituent LG beam. At m < n, the TC of the sum is found to take one of the following four values: TC1 = (m + n)/2, TC2 = TC1 + 1, TC3 = TC1 + 1/2, and TC4 = TC1 – 1/2. We also establish rules for selecting one of the four feasible values of TC. For the sum of two on-axis LG beams, TC of the superposition equals the larger constituent TC, i.e. TC = n. Meanwhile following any infinitesimally small off-axis shift, TC of the sum either remains equal to the pre-shift TC or decreases by an even number. This can be explained by an even number of optical vortices (OV) with TC = –1 instantly ‘arriving’ from infinity that compensate for the same number of OV with TC = +1 born in the superposition. We also show that when two LG beams with different parity are swapped in the superposition, the topological charge of the superposition changes by 1. Interestingly, when superposing two off-axis LG beams tilted to the optical axis so that their superposition produces a structurally stable beam, an infinite number of screw dislocations with TC = +1 are arranged along a certain line, with the total TC of the superposition equal to infinity.
Modeling and simulation of all-optical diffractive neural network based on nonlinear optical materials
Authors: Sun Yichen , Dong Mingli , Yu Mingxin , Lu Lidan , Liang Shengjun , Xia Jiabin , Zhu Lianqing
Published: November 2021

In this Letter, we propose an all-optical diffractive deep neural network modeling method based on nonlinear optical materials. First, the nonlinear optical properties of graphene and zinc selenide (ZnSe) are analyzed. Then the optical limiting effect function corresponding to the saturation absorption coefficient of the nonlinear optical materials is fitted. The optical limiting effect function is taken as the nonlinear activation function of the neural network. Finally, the all-optical diffractive neural network model based on nonlinear materials is established. The numerical simulation results show that the model can effectively improve the nonlinear representation ability of the all-optical diffractive neural network. It provides a theoretical support for the further realization of a photonic artificial intelligence chip based on nonlinear optical materials.
High-power Yb:YAG thin-disk laser with 80% efficiency pumped at the zero-phonon line
Authors: Alabbadi Abdullah , Larionov Mikhail , Fink Florian
Published: November 2021

We report a 3-kW thin-disk laser with 80% optical efficiency employing zero-phonon line pumping at 970 nm. A detailed comparison to conventional pumping at 940 nm is provided, which shows almost twice the pump power density handling capability.
Quantitative demonstration of the superiority of circularly polarized light in fog environments
Authors: Peña-Gutiérrez Sara , Ballesta-Garcia Maria , García-Gómez Pablo , Royo Santiago
Published: November 2021

The polarization behavior of light transmitted through scattering media is studied quantitatively. A division of focal plane (DOFP) imaging polarimeter modified with a wideband quarter-wave plate (QWP) is used to evaluate the linear and circular depolarization signals. This system allows the measurement of the linear and circular co-polarization and cross-polarization channels simultaneously. The experiments are carried out at CEREMA’s 30 m fog chamber under controlled fog density conditions. The polarization memory effect with circularly polarized light is demonstrated to be superior in forward transmission compared to the same phenomena with linearly polarized light when imaging inside a scattering medium. This paves the way for its use in imaging through scattering media for hazard detection in different applications.
Fault detection performance of a multi-mode transmission reflection analysis for a few-mode fiber link
Authors: Zhang Wenping , Liu Feng , He Zhenxing , Xu Lixin , Hu Guijun
Published: November 2021

We propose a novel monitoring technique based on multi-mode transmission reflection analysis for a long-reach few-mode fiber (FMF) based mode division multiplexing system. By launching unmodulated continuous-wave optical light modes into the corresponding spatial modes of the FMF, the transmitted and reflected or backscattered optical powers can be measured and quantitatively analyzed to accurately characterize and locate the fault. The influences of the capture fraction, attenuation coefficient, and Rayleigh backscattering coefficient are discussed, and simulation results show that the proposed method can realize the fault location of the FMF link. Moreover, considering the influence of mode crosstalk on localization accuracy, it is clear that using the monitoring combination modes LP01 and LP21 gives a high precision of 3.58 m.
General case of the overall phase modulation through a dielectric PB-phase metasurface
Authors: Chen Yen-Chun , Zeng Qiu-Chun , Yu Chen-Yi , Wang Chih-Ming
Published: November 2021

In this paper, we propose a simple model, a combination of effective medium theory and the Jones matrix, to analyze the optical properties of a dielectric PB-phase metasurface with an arbitrary incident polarization state. The optical properties, such as the polarization conversion efficiency spectrum, rotation-angle-dependent phase modulation, and phasor diagram, shows a fair agreement with the finite difference time domain method results. This model provides a fast and sufficient accuracy compared to the time-consuming finite element methods. Moreover, the shortness of the proposed model is also discussed.
COVID-19 vaccine confidence and hesitancy among health care workers: A cross-sectional survey from a MERS-CoV experienced nation
Authors: Barry Mazin , Temsah Mohamad-Hani , Alhuzaimi Abdullah , Alamro Nurah , Al-Eyadhy Ayman , Aljamaan Fadi , Saddik Basema , Alhaboob Ali , Alsohime Fahad , Alhasan Khalid , Alrabiaah Abdulkarim , Alaraj Ali , Halwani Rabih , Jamal Amr , Alsubaie Sarah , Al-Shahrani Fatimah S. , Memish Ziad A. , Al-Tawfiq Jaffar A.
Published: November 2021

Objectives

This study aimed to identify coronavirus disease 2019 (COVID-19) vaccine perception, acceptance, confidence, hesitancy, and barriers among health care workers (HCWs).

Methods

An online national cross-sectional pilot-validated questionnaire was self-administered by HCWs in Saudi Arabia, which is a nation with MERS-CoV experience. The main outcome variable was HCWs’ acceptance of COVID-19 vaccine candidates. The factors associated with vaccination acceptance were identified through a logistic regression analysis, and the level of anxiety was measured using a validated instrument to measure general anxiety levels.

Results

Out of the 1512 HCWs who completed the study questionnaire—of which 62.4% were women—70% were willing to receive COVID-19 vaccines. A logistic regression analysis revealed that male HCWs (ORa = 1.551, 95% CI: 1.122–2.144), HCWs who believe in vaccine safety (ORa = 2.151; 95% CI: 1.708–2.708), HCWs who believe that COVID vaccines are the most likely way to stop the pandemic (ORa = 1.539; 95% CI: 1.259–1.881), and HCWs who rely on the Centers for Disease Control and Prevention website for COVID 19 updates (ORa = 1.505, 95% CI: 1.125–2.013) were significantly associated with reporting a willingness to be vaccinated. However, HCWs who believed that the vaccines were rushed without evidence-informed testing were found to be 60% less inclined to accept COVID-19 vaccines (ORa = 0.394, 95% CI: 0.298–0.522).

Conclusion

Most HCWs are willing to receive COVID-19 vaccines once they are available; the satisfactoriness of COVID-19 vaccination among HCWs is crucial because health professionals’ knowledge and confidence toward vaccines are important determining factors for not only their own vaccine acceptance but also recommendation for such vaccines to their patients.
Setting a standard for low reading proficiency: A comparison of the bookmark procedure and constrained mixture Rasch model
Authors: Feseker Tabea , Gnambs Timo , Artelt Cordula
Published: November 2021

In order to draw pertinent conclusions about persons with low reading skills, it is essential to use validated standard-setting procedures by which they can be assigned to their appropriate level of proficiency. Since there is no standard-setting procedure without weaknesses, external validity studies are essential. Traditionally, studies have assessed validity by comparing different judgement-based standard-setting procedures. Only a few studies have used model-based approaches for validating judgement-based procedures. The present study addressed this shortcoming and compared agreement of the cut score placement between a judgement-based approach (i.e., Bookmark procedure) and a model-based one (i.e., constrained mixture Rasch model). This was performed by differentiating between individuals with low reading proficiency and those with a functional level of reading proficiency in three independent samples of the German National Educational Panel Study that included students from the ninth grade (N= 13,897) as well as adults (Ns = 5,335 and 3,145). The analyses showed quite similar mean cut scores for the two standard-setting procedures in two of the samples, whereas the third sample showed more pronounced differences. Importantly, these findings demonstrate that model-based approaches provide a valid and resource-efficient alternative for external validation, although they can be sensitive to the ability distribution within a sample.
Collective language creativity as a trade-off between priming and antipriming
Authors: Monakhov Sergei
Published: November 2021

It is now a matter of scientific consensus that priming, a recency effect of activation in memory, has a significant impact on language users’ choice of linguistic means. However, it has long remained unclear how priming effects coexist with the creative aspect of language use, and the importance of the latter has been somewhat downplayed. By introducing the results of two experiments, for English and Russian native speakers, this paper seeks to explain the mechanisms establishing balance of priming and language creativity. In study 1, I discuss the notion of collective language creativity that I understand as a product of two major factors interacting: cognitive priming effects and the unsolicited desire of the discourse participants to be linguistically creative, that is, to say what one wants to say using the words that have not yet been used. In study 2, I explore how priming and antipriming effects work together to produce collective language creativity. By means of cluster analysis and Bayesian network modelling, I show that patterns of repetition for both languages differ drastically depending on whether participants of the experiment had to communicate their messages being or not being able to see what others had written before them.
Men and infertility in The Gambia: Limited biomedical knowledge and awareness discourage male involvement and exacerbate gender-based impacts of infertility
Authors: Dierickx Susan , Oruko Kelvin Onyango , Clarke Ed , Ceesay Sainey , Pacey Allan , Balen Julie
Published: November 2021

Introduction

Infertility in Sub-Saharan Africa constitutes an important social and public health problem. Yet, there is a paucity of research on the experiences of men living with infertility, especially in West Africa. This study explored men’s aetiological knowledge, views and experiences of infertility in the West Coast region of The Gambia, West Africa.

Methodology

An explorative qualitative study was conducted among men living in the rural and urban communities of the West Coast region of The Gambia using in-depth interviews. Data collection and analysis were performed concurrently, and thematic data analysis was an iterative process carried out using NVivo 11 Analysis Software.

Results

Gambian men had generally poor knowledge of infertility, allocating it to God, spiritual powers and bodily (biomedical) factors. While societal norms meant that infertility was generally attributed to women, some men allocated male-factor infertility to poor sperm quality and impotence. Infertility threatened participants’ sense of masculinity and resulted in psychosocial distress, including stigma, feelings of isolation, and low self-esteem.

Conclusion

Normative gendered frameworks of infertility result in high levels of female responsibilisation in the Gambian context. Yet men diagnosed with infertility experience significant, often unrecognized, psychological and social distress. We therefore call for increased attention to male-factor infertility, and the promotion of male engagement with infertility-care and services, both of which are essential for successfully addressing infertility and it’s psychosocial consequences in The Gambia.
Contextual factors influencing a training intervention aimed at improved maternal and newborn healthcare in a health zone of the Democratic Republic of Congo
Authors: Bogren Malin , Mwambali Sylvie Nabintu , Berg Marie
Published: November 2021

Background

Maternal and neonatal mortality and morbidity in the Democratic Republic of Congo (DRC) are among the highest worldwide. As part of a quality improvement programme in a health zone in the DRC aimed at contributing to reduced maternal and neonatal mortality and morbidity, a three-pillar training intervention around childbirth was developed and implemented in collaboration between Swedish and Congolese researchers and healthcare professionals. The aim of this study is to explore contextual factors influencing this intervention.

Methods

A qualitative research design was used, with data collected through focus group discussions (n = 7) with healthcare professionals involved in the intervention before and at the end (n = 9). Transcribed discussions were inductively analysed using content analysis.

Results

Three generic categories describe the contextual factors influencing the intervention: i) Incentives motivated participants’ efforts to begin a training programme; ii) Involving the local health authorities was important; and (iii) Having physical space, electricity, and equipment in place was crucial.

Conclusions

This study and similar ones highlight that incentives of various types are crucial contextual factors that influence training interventions, and have to be considered already in the planning of such interventions. One such factor is expectations of monetary incentives. To meet this in a small research project like ours would require a reduction of the scale and thus limit the implementation of new evidence-based knowledge into practice aimed at reducing maternal mortality and morbidity.
A machine learning framework for the evaluation of myocardial rotation in patients with noncompaction cardiomyopathy
Authors: Tavares de Melo Marcelo Dantas , Araujo-Filho Jose de Arimatéia Batista , Barbosa José Raimundo , Rocon Camila , Miranda Regis Carlos Danilo , dos Santos Felix Alex , Kalil Filho Roberto , Bocchi Edimar Alcides , Hajjar Ludhmila Abrahão , Tabassian Mahdi , D’hooge Jan , Salemi Vera Maria Cury
Published: November 2021

Aims

Noncompaction cardiomyopathy (NCC) is considered a genetic cardiomyopathy with unknown pathophysiological mechanisms. We propose to evaluate echocardiographic predictors for rigid body rotation (RBR) in NCC using a machine learning (ML) based model.

Methods and results

Forty-nine outpatients with NCC diagnosis by echocardiography and magnetic resonance imaging (21 men, 42.8±14.8 years) were included. A comprehensive echocardiogram was performed. The layer-specific strain was analyzed from the apical two-, three, four-chamber views, short axis, and focused right ventricle views using 2D echocardiography (2DE) software. RBR was present in 44.9% of patients, and this group presented increased LV mass indexed (118±43.4 vs. 94.1±27.1g/m2, P = 0.034), LV end-diastolic and end-systolic volumes (P< 0.001), E/e’ (12.2±8.68 vs. 7.69±3.13, P = 0.034), and decreased LV ejection fraction (40.7±8.71 vs. 58.9±8.76%, P < 0.001) when compared to patients without RBR. Also, patients with RBR presented a significant decrease of global longitudinal, radial, and circumferential strain. When ML model based on a random forest algorithm and a neural network model was applied, it found that twist, NC/C, torsion, LV ejection fraction, and diastolic dysfunction are the strongest predictors to RBR with accuracy, sensitivity, specificity, area under the curve of 0.93, 0.99, 0.80, and 0.88, respectively.

Conclusion

In this study, a random forest algorithm was capable of selecting the best echocardiographic predictors to RBR pattern in NCC patients, which was consistent with worse systolic, diastolic, and myocardium deformation indices. Prospective studies are warranted to evaluate the role of this tool for NCC risk stratification.
Structural and functional studies of D109A human αB-crystallin contributing to the development of cataract and cardiomyopathy diseases
Authors: Hafizi Mahtab , Chebotareva Natalia A. , Ghahramani Maryam , Moosavi-Movahedi Faezeh , Khaleghinejad Seyed Hossein , Kurganov Boris I. , Moosavi-Movahedi Ali Akbar , Yousefi Reza
Published: November 2021

αB-crystallin (heat shock protein β5/HSPB5) is a member of the family of small heat shock proteins that is expressed in various organs of the human body including eye lenses and muscles. Therefore, mutations in the gene of this protein (CRYAB) might have many pathological consequences. A new mutation has recently been discovered in the α-crystallin domain of this chaperone protein which replaces aspartate 109 with alanine (D109A). This mutation can cause myofibrillar myopathy (MFM), cataracts, and cardiomyopathy. In the current study, several spectroscopic and microscopic analyses, as well as gel electrophoresis assessment were applied to elucidate the pathogenic contribution of human αB-crystallin bearing D109A mutation in development of eye lens cataract and myopathies. The protein oligomerization, chaperone-like activity and chemical/thermal stabilities of the mutant and wild-type protein were also investigated in the comparative assessments. Our results suggested that the D109A mutation has a significant impact on the important features of human αB-crystallin, including its structure, size of the protein oligomers, tendency to form amyloid fibrils, stability, and chaperone-like activity. Given the importance of aspartate 109 in maintaining the proper structure of the α-crystallin domain, its role in the dimerization and chaperone-like activity, as well as preserving protein stability through the formation of salt bridges; mutation at this important site might have critical consequences and can explain the genesis of myopathy and cataract disorders. Also, the formation of large light-scattering aggregates and disruption of the chaperone-like activity by D109A mutation might be considered as important contributing factors in development of the eye lens opacity.
Direct-to-consumer genetic testing: Prospective users’ attitudes toward information about ancestry and biological relationships
Authors: Hazel James W. , Hammack-Aviran Catherine , Brelsford Kathleen M. , Malin Bradley A. , Beskow Laura M. , Clayton Ellen Wright
Published: November 2021

Direct-to-consumer genetic testing is marketed as a tool to uncover ancestry and kin. Recent studies of actual and potential users have demonstrated that individuals’ responses to the use of these tests for these purposes are complex, with privacy, disruptive consequences, potential for misuse, and secondary use by law enforcement cited as potential concerns. We conducted six focus groups with a diverse sample of participants (n = 62) who were aware of but had not used direct-to-consumer genetic tests, in an effort to understand more about what people considering these tests think about the potential value, risks, and benefits of such testing, taking into account use by third parties, such as potential kin and law enforcement. Participants differed widely in the perceived value of direct-to-consumer genetic tests for ancestry and kinship information for their own lives, including the desirability of contact with previously unknown relatives. Some perceived ancestry testing as mere curiosity or entertainment, while others, particularly those who had gaps in their family history, few living relatives, or who were adopted, saw greater value. Concerns about intrusion into one’s life by purported kin and control of data were widespread, with many participants expressing concern about secondary uses of data that could harm users or their families. The use of direct-to-consumer genetic tests data for forensic genealogy elicited a particularly wide array of reactions, both spontaneously and in response to specific discussion prompts, mirroring the current public debate about law enforcement access to such data. The themes uncovered through our investigation warrant specific attention in the continued development of the science, policy, and practice of commercial direct-to-consumer genetic testing.
Influences of study design on the effectiveness of consensus messaging: The case of medicinal cannabis
Authors: Landrum Asheley R. , Davis Brady , Huxster Joanna , Carrasco Heather
Published: November 2021

This study examines to what extent study design decisions influence the perceived efficacy of consensus messaging, using medicinal cannabis as the context. We find that researchers’ decisions about study design matter. A modified Solomon Group Design was used in which participants were either assigned to a group that had a pretest (within-subjects design) or a posttest only group (between-subjects design). Furthermore, participants were exposed to one of three messages—one of two consensus messages or a control message—attributed to the National Academies of Sciences, Engineering and Medicine. A consensus message describing a percent (97%) of agreeing scientists was more effective at shifting public attitudes than a consensus message citing substantial evidence, but this was only true in the between-subject comparisons. Participants tested before and after exposure to a message demonstrated pre-sensitization effects that undermined the goals of the messages. Our results identify these nuances to the effectiveness of scientific consensus messaging, while serving to reinforce the importance of study design.
Effects of obesity and foot arch height on gait mechanics: A cross-sectional study
Authors: Kim Daekyoo , Lewis Cara L. , Gill Simone V.
Published: November 2021

Foot arch structure contributes to lower-limb joint mechanics and gait in adults with obesity. However, it is not well-known if excessive weight and arch height together affect gait mechanics compared to the effects of excessive weight and arch height alone. The purpose of this study was to determine the influences of arch height and obesity on gait mechanics in adults. In this study, 1) dynamic plantar pressure, 2) spatiotemporal gait parameters, 3) foot progression angle, and 4) ankle and knee joint angles and moments were collected in adults with normal weight with normal arch heights (n = 11), normal weight with lower arch heights (n = 10), obesity with normal arch heights (n = 8), and obesity with lower arch heights (n = 18) as they walked at their preferred speed and at a pedestrian standard walking speed, 1.25 m/s. Digital foot pressure data were used to compute a measure of arch height, the Chippaux-Smirak Index (CSI). Our results revealed that BMI and arch height were each associated with particular measures of ankle and knee joint mechanics during walking in healthy young adults: (i) a higher BMI with greater peak internal ankle plantar-flexion moment and (ii) a lower arch height with greater peak internal ankle eversion and abduction moments and peak internal knee abduction moment (i.e., external knee adduction moment). Our results have implications for understanding the role of arch height in reducing musculoskeletal injury risks, improving gait, and increasing physical activity for people living with obesity.
Health promotion interventions for the control of hypertension in Africa, a systematic scoping review from 2011 to 2021
Authors: Shin Jinhee , Konlan Kennedy Diema , Mensah Eugenia
Published: November 2021

Background

A proportion of hypertension patients live in developing countries with low awareness, poor control capabilities, and limited health resources. Prevention and control of hypertension can be achieved by applying both targeted and population-based health promotion interventions. This study synthesised the health promotion interventions for the control of hypertension in Africa.

Methods

An in-depth search of PubMed, CINAHL, EMBASE, Cochrane library, web of science, google scholar yielded 646 titles and 615 after duplicates were removed. Full text (112) was screened, and ten articles were selected. The data analysis method was thematic analysis through the incorporation of convergent synthesis. The major sub-themes that were identified were reduction in the prevalence of hypertension, increase in knowledge, impact and feasibility, role in the reduction of risk factors, and the cost associated with health promotion interventions.

Results

Health promotion interventions led to a remarkable decrease in the prevalence of hypertension, increased knowledge and awareness in the intervention compared to the control groups. Community-based interventions were noted to have a positive impact on people’s adoption of measures to reduce risk or identify early symptoms of hypertension. There was a significant relationship for the reduction in salt consumption, smoking, alcohol use, and increased physical activity after the administration of an intervention. Interventions using community health workers were cost-effective.

Conclusion

To sustain health promotion interventions and achieve control of hypertension especially in the long term, interventions must be culturally friendly and incorporate locally available resources in Africa.
Nd:YAG fourth harmonic (266-nm) generation for corneal reshaping procedure: An ex-vivo experimental study
Authors: Abdelhalim Ibrahim , Hamdy Omnia , Hassan Aziza Ahmed , Elnaby Salah Hassab
Published: November 2021

Corneal reshaping is a common medical procedure utilized for the correction of different vision disorders relying on the ablation effect of the UV pulsed lasers, especially excimer lasers (ArF) at 193 nm. This wavelength is preferred in such medical procedures since laser radiation at 193 nm exhibits an optimum absorption by corneal tissue. However, it is also significantly absorbed by the water content of the cornea resulting in an unpredictability in the clinical results, as well as the high service and operation cost of the commercial ArF excimer laser device. Consequently, other types of solid-state UV pulsed lasers have been introduced. The present work investigates the ablation effect of solid-state laser at 266 nm in order to be utilized in corneal reshaping procedures. Different number of pulses has been applied to Polymethyl Methacrylate (PMMA) and ex-vivo rabbit cornea to evaluate the ablation effect of the produced laser radiation. PMMA target experienced ellipse-like ablated areas with a conical shape in the depth. The results revealed an almost constant ablation area regardless the number of laser pulses, which indicates the stability of the produced laser beam, whereas the ablation depth increases only with increasing the number of laser pulses. Examination of the ex-vivo cornea showed a significant tissue undulation, minimal thermal damage, and relatively smooth ablation surfaces. Accordingly, the obtained 266-nm laser specifications provide promising alternative to the traditional 193-nm excimer laser in corneal reshaping procedure.
Panax Ginseng alleviates thioacetamide-induced liver injury in ovariectomized rats: Crosstalk between inflammation and oxidative stress
Authors: Mostafa Rasha E. , Shaffie Nermeen M. , Allam Rasha M.
Published: November 2021

Liver diseases impose a substantial health problem. Female hormones play a crucial role in the protection against chronic inflammatory diseases. Fifty female rats were allocated into five groups (n = 10). Group I comprised sham-operated rats. The remaining groups underwent ovariectomy at the beginning of the experiment. Group II served as the ovariectomy-control group. Groups III, IV & V received thioacetamide (TAA; 300 mg/kg; i.p.) to induce liver injury 6 weeks after ovariectomy. Group III served as the TAA-control group. Groups IV & V received panax ginseng (100 and 300 mg/kg/day, p.o.) for 6 weeks post TAA administration. All groups were investigated for liver function tests along with total antioxidant capacity (TAC), tumor necrosis factor-α (TNF-α) and advanced glycation end products (AGEs). Histopathological examination of liver tissues was performed followed by immunohistochemical staining for nuclear factor kappa-B (NF-kβ p65) and myeloperoxidase (MPO). Ovariectomized-rats showed a non-significant change in the measured parameters while TAA administration resulted in significant liver damage. Panax ginseng at both dose levels significantly improved the serum liver function tests and TAC along with decreasing the AGEs and TNF-α. It also restored the histopathological picture of liver tissue and decreased hepatic tissue inflammation via reduction of MPO and NF-kβ p65 immunoreactivity. The current study is the first to elucidate the effect of panax ginseng against TAA-induced liver injury in ovariectomized rats which mimic aged post-menopausal estrogen-deficient females. The study demonstrates the crosstalk between AGEs, NF-kβ and MPO in the modulation of inflammation. Panax ginseng possesses antioxidant and anti-inflammatory properties.
Individual dairy cow identification based on lightweight convolutional neural network
Authors: Li Shijun , Fu Lili , Sun Yu , Mu Ye , Chen Lin , Li Ji , Gong He
Published: November 2021

In actual farms, individual livestock identification technology relies on large models with slow recognition speeds, which seriously restricts its practical application. In this study, we use deep learning to recognize the features of individual cows. Alexnet is used as a skeleton network for a lightweight convolutional neural network that can recognise individual cows in images with complex backgrounds. The model is improved for multiple multiscale convolutions of Alexnet using the short-circuit connected BasicBlock to fit the desired values and avoid gradient disappearance or explosion. An improved inception module and attention mechanism are added to extract features at multiple scales to enhance the detection of feature points. In experiments, side-view images of 13 cows were collected. The proposed method achieved 97.95% accuracy in cow identification with a single training time of only 6 s, which is one-sixth that of the original Alexnet. To verify the validity of the model, the dataset and experimental parameters were kept constant and compared with the results of Vgg16, Resnet50, Mobilnet V2 and GoogLenet. The proposed model ensured high accuracy while having the smallest parameter size of 6.51 MB, which is 1.3 times less than that of the Mobilnet V2 network, which is famous for its light weight. This method overcomes the defects of traditional methods, which require artificial extraction of features, are often not robust enough, have slow recognition speeds, and require large numbers of parameters in the recognition model. The proposed method works with images with complex backgrounds, making it suitable for actual farming environments. It also provides a reference for the identification of individual cows in images with complex backgrounds.
Deep learning algorithm in detecting intracranial hemorrhages on emergency computed tomographies
Authors: Kundisch Almut , Hönning Alexander , Mutze Sven , Kreissl Lutz , Spohn Frederik , Lemcke Johannes , Sitz Maximilian , Sparenberg Paul , Goelz Leonie
Published: November 2021

Background

Highly accurate detection of intracranial hemorrhages (ICH) on head computed tomography (HCT) scans can prove challenging at high-volume centers. This study aimed to determine the number of additional ICHs detected by an artificial intelligence (AI) algorithm and to evaluate reasons for erroneous results at a level I trauma center with teleradiology services.

Methods

In a retrospective multi-center cohort study, consecutive emergency non-contrast HCT scans were analyzed by a commercially available ICH detection software (AIDOC, Tel Aviv, Israel). Discrepancies between AI analysis and initial radiology report (RR) were reviewed by a blinded neuroradiologist to determine the number of additional ICHs detected and evaluate reasons leading to errors.

Results

4946 HCT (05/2020-09/2020) from 18 hospitals were included in the analysis. 205 reports (4.1%) were classified as hemorrhages by both radiology report and AI. Out of a total of 162 (3.3%) discrepant reports, 62 were confirmed as hemorrhages by the reference neuroradiologist. 33 ICHs were identified exclusively via RRs. The AI algorithm detected an additional 29 instances of ICH, missed 12.4% of ICH and overcalled 1.9%; RRs missed 10.9% of ICHs and overcalled 0.2%. Many of the ICHs missed by the AI algorithm were located in the subarachnoid space (42.4%) and under the calvaria (48.5%). 85% of ICHs missed by RRs occurred outside of regular working-hours. Calcifications (39.3%), beam-hardening artifacts (18%), tumors (15.7%), and blood vessels (7.9%) were the most common reasons for AI overcalls. ICH size, image quality, and primary examiner experience were not found to be significantly associated with likelihood of incorrect AI results.

Conclusion

Complementing human expertise with AI resulted in a 12.2% increase in ICH detection. The AI algorithm overcalled 1.9% HCT.

Trial registration

German Clinical Trials Register (DRKS-ID: DRKS00023593).
Factors influencing willingness to pay for accident risk reduction among personal car drivers in Thailand
Authors: Jomnonkwao Sajjakaj , Wisutwattanasak Panuwat , Ratanavaraha Vatanavongs
Published: November 2021

Thailand ranks near the top for the road accident fatality rate worldwide, and more and more vehicles are being registered in Thailand every year. Obtaining the opinions of road commuters may help us reduce road accidents in Thailand. This study seeks to understand damage value in road accidents for personal car drivers in Thailand, using the willingness to pay approach and establishing factors affecting willingness to pay with the theory of planned behavior (TPB). This study obtained data using questionnaires in face-to-face interviews with 1,650 personal cars drivers in Thailand. The average willingness to pay (WTP) for 50% fatality or injury reduction was 23.00 baht/person/50 km trip (US $0.74/person/50 km trip). We obtained the value of statistical life (VSL), assessing this to fall between US $815,385 and US $872,942, and the value of statistical injury (VSI), between US $150,059 and US $160,652. Overall, national damage was assessed at US $4,701,981,170 annually. According to the analysis of factors affecting WTP, TPB comprises four factors, namely, driver attitude, subjective norm, perceived behavioral control, and behavioral intention. Analysis using structural equation modeling (SEM) found all mentioned factors were relevant and positively influenced personal car drivers’ WTP in Thailand, with a statistical significance at a 99% confidence interval (p < 0.01). This study can develop recommendations for relevant organizations to analyze the results as part of considerations regarding budget allocation and developments on road safety policy due to driver attitude as important as environmental factors or any other factors.
Antibiotic resistance among invasive Neisseria meningitidis isolates in England, Wales and Northern Ireland (2010/11 to 2018/19)
Authors: Willerton Laura , Lucidarme Jay , Walker Andrew , Lekshmi Aiswarya , Clark Stephen A. , Walsh Lloyd , Bai Xilian , Lee-Jones Lisa , Borrow Ray
Published: November 2021

Invasive meningococcal disease (IMD), caused by Neisseria meningitidis, can have a fatality rate as high as 10%, even with appropriate treatment. In the UK, penicillin is administered to patients in primary care whilst third generation cephalosporins, cefotaxime and ceftriaxone, are administered in secondary care. The first-choice antibiotic for chemoprophylaxis of close contacts is ciprofloxacin, followed by rifampicin. Immunocompromised individuals are often recommended antibiotic chemoprophylaxis and vaccination due to a greater risk of IMD. Resistance to antibiotics among meningococci is relatively rare, however reduced susceptibility and resistance to penicillin are increasing globally. Resistance to third generation cephalosporins is seldom reported, however reduced susceptibility to both cefotaxime and ceftriaxone has been observed. Rifampicin resistance has been reported among meningococci, mainly following prophylaxis, and ciprofloxacin resistance, whilst uncommon, has also been reported across the globe. The Public Health England Meningococcal Reference Unit receives and characterises the majority of isolates from IMD cases in England, Wales and Northern Ireland. This study assessed the distribution of antibiotic resistance to penicillin, rifampicin, ciprofloxacin and cefotaxime among IMD isolates received at the MRU from 2010/11 to 2018/19 (n = 4,122). Out of the 4,122 IMD isolates, 113 were penicillin-resistant, five were ciprofloxacin-resistant, two were rifampicin-resistant, and one was cefotaxime-resistant. Penicillin resistance was due to altered penA alleles whilst rifampicin and ciprofloxacin resistance was due to altered rpoB and gyrA alleles, respectively. Cefotaxime resistance was observed in one isolate which had an altered penA allele containing additional mutations to those harboured by the penicillin-resistant isolates. This study identified several isolates with resistance to antibiotics used for current treatment and prophylaxis of IMD and highlights the need for continued surveillance of resistance among meningococci to ensure continued effective use.