bluuebunny/crossref_metadata_2025 huggingface dataset:
Human Islets Contain a Beta Cell Type That Expresses Proinsulin But Not the Enzyme That Converts the Precursor to Insulin
Authors: Teitelman Gladys
Published: October 2020

In pancreatic beta cells, proinsulin (ProIN) undergoes folding in endoplasmic reticulum/Golgi system and is translocated to secretory vesicles for processing into insulin and C-peptide by the proprotein convertases (PC)1/3 and PC2, and carboxypeptidase E. Human beta cells show significant variation in the level of expression of PC1/3, the critical proconvertase involved in proinsulin processing. To ascertain whether this heterogeneity is correlated with the level of expression of the prohormone and mature hormone, the expression of proinsulin, insulin, and PC1/3 in human beta cells was examined. This analysis identified a human beta cell type that expressed proinsulin but lacked PC1/3 (ProIN+PC1/3−). This beta cell type is absent in rodent islets and is abundant in human islets of adults but scarce in islets from postnatal donors. Human islets also contained a beta cell type that expressed both proinsulin and variable levels of PC1/3 (ProIN+PC1/3+) and a less abundant cell type that lacked proinsulin but expressed the convertase (ProIN−PC1/3+). These cell phenotypes were altered by type 2 diabetes. These data suggest that these three cell types represent different stages of a dynamic process with proinsulin folding in ProIN+PC1/3− cells, proinsulin conversion into insulin in ProIN+PC1/3+cells, and replenishment of the proinsulin content in ProIN−PC1/3+ cells:
Conciones ex historicis excerptae. Nuevos estudios sobre las antologías de discursos historiográficos
Authors: Iglesias-Zoido Juan Carlos
Published: September 2020

El conjunto de estudios recogidos en este libro está dedicado a un tema al que, hasta hace poco, la crítica había prestado una escasa atención: las antologías de discursos de la historiografía grecolatina publicadas en el Renacimiento y en la Alta Edad Moderna. Este tipo de publicaciones, que conforman un auténtico género editorial que gozó de un enorme éxito y de una amplia aceptación por parte del público contemporáneo, proporciona información de gran interés para profundizar en aspectos esenciales de la historia de la retórica, de los procesos de instrucción e, incluso, de la historia de las ideas en Europa durante los siglos XVI y XVII.
El enfoque de género en el acuerdo de paz colombiano y su aporte a la construcción de una cultura de paz
Authors: Serrano Ávila Ana María
Published: October 2020

El Acuerdo Final para la terminación del conflicto y la construcción de una paz estable y duradera firmado en noviembre de 2016, entre el Estado colombiano y las Fuerzas Armadas Revolucionarias Colombianas —Ejército del Pueblo (FARC-EP), representa para la sociedad colombiana la posibilidad de construir un país incluyente, democrático y, sobre todo, en donde las acciones violentas producto de la guerra, no sean más las protagonistas. Uno de los elementos que se destacan del Acuerdo Paz (AP), es la transversalización de la perspectiva de género en los seis puntos pactados, hecho que se configura como un aporte al trabajo para la erradicación de las violencias simbólicas, culturales y estructurales que sufren las mujeres por su condición. Este hecho es uno de los desafíos de la implementación del acuerdo, ya que supone superar elementos de la violencia directa producto del conflicto, como también propone la superación o al menos trabajar en la reducción de las violencias culturales y estructurales.
Ocimum sanctum Linn. ethanolic extract inhibits angiogenesis in human lung adenocarcinoma (a549) cells
Authors: Wihadmadyatami Hevi , Hening Puspa , Kustiati Ulayatul , Kusindarta Dwi Liliek , Triyono Teguh , Supriatno Supriatno
Published: September 2020

Background and Aim: Ocimum sanctum (OS) is a herbal plant, which is easy to find and is widely used as an alternative medication. The previous studies have shown that several species of OS extract have therapeutic properties, and in some cases, antitumor properties. Furthermore, several data have shown the antiproliferative effects of OS extract in cases of breast cancer, human fibrosarcoma, and oral cancer. Lung adenocarcinoma is a major cause of male cancer worldwide; however, the effect of OS (of Indonesian origin) on the metastasis of human alveolar pulmonary adenocarcinoma A549 cells remains unclear. This study aimed to analyze the antiangiogenic effects of OS ethanolic extract in A549 lung adenocarcinoma cells.

Materials and Methods: An angiogenesis assay was performed by seeding A549 cells on extracellular matrix solution and observing tube formation using an inverted microscope. Enzyme-linked immunosorbent assay for αvβ3, matrix metalloproteinase (MMP)-2, and MMP-9 was performed by analyzing the cell lysate after a given treatment.

Results: OS ethanolic extract significantly inhibited tube formation of A549 cells and suppressed the expression of integrin αvβ3, MMP-2, and MMP-9.

Conclusion: Our findings indicate that OS ethanolic extract disrupts angiogenesis of A549 cells, which may result from the disruption of cell migration and proliferation as a consequence of downregulation of αvβ3, MMP-2, and MMP-9. Taken together, OS ethanolic extract may represent a good therapeutic candidate for the treatment of metastasis in lung adenocarcinoma. Further studies are warranted to further establish the efficacy of OS in the treatment of lung adenocarcinoma.
Scientific and Methodological Approaches to the Evaluation of Marketing Management of Enterprises in the Context of International Diversification
Authors: Tanasiichuk Alona , Hromova Olha , Kovalchuk Svetlana , Perevozova Iryna , Khmelevskyi Oleg
Published: September 2020

Marketing management of business activities in the context of international diversification involves the construction of an appropriate system of information gathering, study of foreign markets, planning, implementation and control of the marketing program, risk and profit assessment, effectiveness of marketing decisions, development of marketing strategy of the enterprise, which allows obtaining the maximum positive result with minimal marketing costs. In this study, further development of scientific and methodological approaches to determining the state of marketing management of the activities of agricultural enterprises of Ukraine under the conditions of international diversification, consisting in the identification of problematic issues arising in the course of international business diversification; quantitative and qualitative assessment and determination of the degree of diversification of the enterprise in different markets, as well as conducting market research of the most important business segments of consumers in foreign markets  and selecting the optimal exit strategy of a diversified international markets.

Keywords: marketing management, concept of marketing management, international diversification, effectiveness of marketing management, planning, organization and control of enterprise marketing management, evaluation of the degree of diversification of activities, diversified company
José Carlos Libâneo: gênese e desenvolvimento de seu pensamento didático
Authors: Puentes Roberto Valdés , Longarezi Andréa Maturano
Published: September 2020

O artigo tem como objetivo estabelecer e abordar os principais momentos no processo de gênese e desenvolvimento do pensamento didático de J. C. Libâneo (1945- ), a partir da adaptação da metodologia construtivo-interpretativa para análise de documentos bibliográficos. O autor é responsável por uma obra que extrapola os limites geográficos brasileiros dada a magnitude e profundidade teórica de suas principais teses. A gênese e o desenvolvimento desse pensamento podem ser localizados na conjuntura contraditória e de tensões ideológico-políticas que caracterizaram as décadas de 1970 e 1980, assinalada por um intenso movimento de democratização e transformação social. De um pensamento didático filosófico daí emergente, se sobressai, entre suas contribuições teóricas, uma aproximação com as teses psicológicas histórico-culturais, que tem seu marco no ano de 1991; intensificadas, a partir de 2002, pela análise dos princípios da Didática Desenvolvimental, do conteúdo da Atividade de Estudo e do método do abstrato ao concreto como forma de desenvolvimento do pensamento teórico, com foco nos aportes do sistema Elkonin-Davidov-Repkin, tomado, particularmente, pelas contribuições do grupo de Moscou e de V. V. Davidov.
Promoting a Culturally Safe Evaluation of an On-the-Land Wellness Program in the Inuvialuit Settlement Region
Authors: Ollier Mary , Giles Audrey R. , Etter Meghan , Ruttan Jimmy , Elanik Nellie , Goose Ruth , Ipana Esther
Published: September 2020

In 2017, the Inuvialuit Regional Corporation partnered with a diverse research advisory team to understand how Project Jewel, a land-based program in the Inuvialuit Settlement Region, could be evaluated in a way that promotes cultural safety (i.e., in a way that addresses the social, historical, and economic contexts that shape participants’ experiences). We used community-based research methodology to approach the study, through which semi-structured interviews, sharing circles, and photovoice were identified by the community advisory board and research advisory team as appropriate research methods for this project. After piloting and evaluating these methods, we then used thematic analysis to analyze the data, which included images and transcripts, to identify the components of a culturally safe evaluation: centring the land, building relationships, working with words and pictures, and promoting benefit over harms through program aftercare. Our community-based research and findings provide a template of a meaningful evaluation framework that other on-the-land programs can use if contextualized within local cultural practices and values.
Use of Large Balloon Catheter to Treat Infants With Pulmonary Valve Stenosis
Authors: Ohnishi Yuji , Okada Seigo , Furuta Takashi , Suzuki Yasuo , Iwaya Yuki , Hasegawa Shunji , Muneuchi Jun
Published: September 2020

Balloon pulmonary valvuloplasty is a safe and effective treatment for isolated pulmonary valve stenosis. Several balloon catheters are available for this procedure in neonates and infants. However, obtaining additional vascular access for the double-balloon technique in this population is troublesome, and tricuspid valve injury is a concern. We used a TMP PED balloon catheter to perform valvuloplasty in 2 infants with isolated pulmonary valve stenosis. This thin-walled, relatively large 12-mm balloon catheter can be delivered through a small-diameter sheath. In both cases, the transpulmonary pressure gradient was reduced without causing any valvular or vascular injuries. Neither patient had recurrent pulmonary valve stenosis. Together, these cases highlight the suitability and feasibility of using the 12-mm TMP PED balloon catheter for treating young infants with valvular stenosis.
High-Grade Atrioventricular Block Associated With Acute Influenza
Authors: Ergle Kevin , Gooden Janelle Y. , Ahmed Mustafa M.
Published: September 2020

Influenza causes cardiac and pulmonary complications that can lead to death. Its effect on the conduction system, first described a century ago, has long been thought to be fairly benign. We report 2 cases of high-grade atrioventricular block associated with acute influenza infection. Both patients—a 50-year-old woman with no history of cardiac disease or conduction abnormalities and a 20-year-old man with a history of complex congenital heart disease and conduction abnormalities—received a permanent pacemaker. In the first case, pacemaker interrogation at 4 months revealed persistent atrioventricular block. In the second case, pacemaker interrogation at 3 months suggested resolution. Whether such influenza-associated changes are transient or permanent remains unknown. We recommend keeping a careful watch on influenza patients with cardiac rhythm abnormalities and monitoring them closely to see if the problem resolves.
Altered Mental Status and Hyponatremia After 20 Hours of Amiodarone Therapy
Authors: Qi Andrea , Moscona John C. , Reed Justin , Le Jemtel Thierry H.
Published: September 2020

A 66-year-old woman with no relevant medical history presented at the emergency department with new-onset atrial fibrillation. We initiated intravenous amiodarone therapy. At 20 hours, the patient experienced severe neurologic symptoms, hyponatremia, and syndrome of inappropriate antidiuretic hormone. We discontinued amiodarone, infused saline solution, and restricted the patient's fluid intake. She recovered in 3 days. This case illustrates that amiodarone-induced syndrome of inappropriate antidiuretic hormone with hyponatremia can occur far earlier than expected during acute amiodarone therapy.
ANALISIS SENTIMEN GOJEK PADA MEDIA SOSIAL TWITTER DENGAN KLASIFIKASI SUPPORT VECTOR MACHINE (SVM
Authors: Fitriyah Nur , Warsito Budi , Maruddani Di Asih I
Published: September 2020

Appearance of PT Aplikasi Karya Anak Bangsa or as known as Gojek since 2015 give a convenience facility to people in Indonesia especially in daily activities. Sentiment analysis on Twitter social media can be the option to see how Gojek users respond to the services that have been provided. The response was classified into positive sentiment and negative sentiment using Support Vector Machine method with model evaluation 10-fold cross validation. The kernel used is the linear kernel and the RBF kernel. Data labeling can be done with manually and sentiment scoring. The test results showed that the RBF kernel gets overall accuracy and the highest kappa accuracy on manual data labeling and sentiment scoring. On manual data labeling, the overall accuracy is 79.19% and kappa accuracy is 16.52%. While the labeling of data with sentiment scoring obtained overall accuracy of 79.19% and kappa accuracy of 21%. The greater overall accuracy value and kappa accuracy obtained, the better performance of the classification model. Keywords: Gojek, Twitter, Support Vector Machine, overall accuracy, kappa accuracy
Iron Deficiency as Cause of Dysphagia and Burning Mouth (Plummer-Vinson or Kelly-Patterson Syndrome): a Case Report
Authors: Radochová Vladimíra , Slezák Radovan , Radocha Jakub
Published: October 2020

The clinical presentation of iron deficiency can be very heterogeneous, including various oral and other mucosal problems. Here, in this case, we report the patient with burning mouth and dysphagia symptoms where iron deficiency was found to be the underlying cause after several months of investigations. This clinical syndrome is called Plummer-Vinson syndrome. It is sporadic with an incidence less than 0.1% of patients suffering from iron deficiency anemia.
Foliar fortification of Copper (Cu) in Glycine max L. for the protection against Asian Soybean Rust (Phakopsora pachyrhizi Syd. & P.Syd.)
Authors: Bedin Edevan , Caverzan Andréia , Silveira Diógenes Cecchin , Chavarria Geraldo
Published: October 2020

The Asian Soybean Rust caused by the fungus Phakopsora pachyrhizi is one of the serious phytosanitary problems faced by soybean [Glycine max (L.) Merrill], which cause up to 80% yield loss. An alternative for the integrated management of the disease is the use of mineral nutrition together with phytosanitary treatments. Thus, the objective of this study is to understand the effect of foliar fortification with copper (Cu) along with phytosanitary treatments in the soybean reaction to Rust by lignin content variation in leaf tissues, and how it reflects the yield. The experimental design was a randomized block with four replicates. Four concentrations Cu (30, 60, 90, 120 g Cu ha-1) were tested in two distinct sources (cuprous oxide and copper carbonate) together with phytosanitary treatments. Evaluations were made to determine the progression of Asian Rust severity, micronutrient content in leaves and grains, as well as lignin content in leaves. The grain yield components and productivity were also evaluated. The Cu contents in the soybean leaves and grains were influenced by foliar spraying. Foliar spray with Cu retarded the disease progression, reducing the severity of Asian Rust and positively impacting grain yield. The amount of lignin present in the leaves was altered considerably with the application of the Cu associated with phytosanitary treatments. The results suggest that the leaf nutrition with copper together with phytosanitary treatments, may reduce the rust severity and improvement the plant performance. Future research with Cu application and analysis of specific enzymes, secondary metabolites and cell wall thickness may further contribute to the understanding of the role of Cu in defence against Asian Soybean Rust.
Modalities of NADP-malic enzyme activities under light and darkness indicate its regulation with reference to C4 weed
Authors: Sarkar Bipul , De Arnab Kumar , Saha Indraneel , Ghosh Arijit , Dolui Debabrata , Adak M K
Published: October 2020

NADP –ME is the key enzyme for decarboxylation reactions in C4 CO2 concentration pathways. So, Amaranthus viridis has been evaluated with regards to photosynthetic NADP-malic enzyme for its response under light and darkness. Illumination (1000–1200 µEm-2s-1) for 40 minutes under 2 mM bicarbonate (HCO3-) sensitivity increased activity by 1.97 & 3.77-fold over darkness under 4.0 mM and 0.01 mM malate respectively. Limiting (0.01 mM) and saturated (4.0 mM) malate concentration had significant changes in enzyme activities. The different kinetic parameters indicated had the feedback inhibition under illumination. The activity with the inducer (citrate and succinate) and inhibitor (pyruvate and oxalate) was significant with substrate concentrations. Dithiol had reduced the activity by inhibition of the diminishing effect of light activation treatment. Therefore, NADP-ME is stringently regulated by redox changes with illumination as a key factor. Moreover, the pattern of polymorphic gene expression may be supportive in molecular modulation under light/darkness. This study may support the role of NADP-ME as a biomarker for C4 weed species under oxidative stress through light/darkness.
Pathogenic complexity of septoria spot disease of wheat in northern Kazakhstan
Authors: Babkenova Sandukash Amantaevna , Babkenov Adylkhan Temirhanovich , Pakholkova Elena Vasilyevna , Kanafin Belgibay Kamalovich
Published: October 2020

Northern Kazakhstan is the main zone of spring wheat cultivation where, 85 % of the cultivated area is located. There is not a single variety resistant to Septoria spot among the varieties approved for use. The frequency of epiphytoties of wheat diseases in the northern part of Kazakhstan is four cases every ten years. During the years of epiphytotic development of brown rust and Septoria spot with the dominance of a particular disease, the yield of spring wheat is reduced by 25 % or more. Knowledge of the species composition of pathogens of Septoria spot allows a more focused approach to the study and creation of varieties of wheat resistant to this disease. The aim of the research is to study the species of Septoria spot pathogens in wheat in Northern Kazakhstan. In 2018–2019, the pathogenic complex of the causative agents of wheat Septoria spot was studied. The collection of leaves affected by Septoria spot was carried out on spring wheat varieties in the steppe, forest-steppe zones of Northern Kazakhstan. The species composition of Septoria pathogens was determined from microscopic preparations from the collected samples; which were represented by three types of septorial fungi: Septoria tritici, Stagonospora nodorum, Stagonospora avenae. In the steppe and forest-steppe zones of Northern Kazakhstan, the dominant species was S. tritici followed by S. nodorum.
Analyses of variability, euclidean clustering and principal components for genetic diversity of eight Tossa Jute (Corchorus olitorius L.) genotypes
Authors: Mukul Md. Mia , Akter Nargis , Mostofa Md. Golam , Rahman Md. Sohanur , Hossain Md. Al-Emran , Roy Dinesh Chandra , Jui Sadia Afrin , Karim Md. Meftahul , Ferdush Jannatul , Hoque Md. Mozammel , Mollah Md. Abul Fazal
Published: October 2020

An investigation was done to assess the genetic variability, character associations, and genetic diversity of eight jute genotypes for seven morphological traits in a randomised complete block design at Bangladesh Jute Research Institute during 15 March, 2018 to 31 December, 2019. Analyses results revealed significant differences (P<0.01) among all genotypes for studied traits indicating the presence of variability. All the lines performed better than one control (JRO-524), and the line (O-0412-9-4) provided good results for desired traits than all controls. Jute fibre yield showed the highest broad sense heritability (98.54%). The studied jute morphological traits i.e. Plant population, the plant height, green weight, dry fibre yield and dry stick yield gave high heritability along with high genotypic and phenotypic variances, genetic advances in percent of the mean, highly significant and positive correlations. It indicates the possibility of crop improvement through phenotypic selection and maximum genetic gain, simultaneously at the genotypic-phenotypic level. Clustering analysis grouped all genotypes into three distinct clusters. The cluster II showed the highest mean values for all traits followed by cluster I and III. The first two principal components with higher Eigen values (>1.0) accounted for 90.88% of the total variation in the principal component analysis. PCA and cluster analyses indicated that the advanced breeding line O-0412-9-4 made its individual cluster II with higher inter-cluster distance and higher fibre yield (3.12 t ha-1). The investigation was done to select the genotype(s) with good fibre yield and distinct features in respect of developing high yielding Tossa jute variety for cultivation in the farmers’ field. This genotype O-0412-9-4 was selected based on higher plant height, base diameter, fibre yield content. It will be developed as a high yielding variety considering its’ higher genetic variability, heritability, genetic advance, significant associations for desirable characters.
Diversity of wild edible plants traditionally used by the Galo tribe of Indian Eastern Himalayan state of Arunachal Pradesh
Authors: Gajurel Padma Raj , Doni Tajum
Published: October 2020

Wild edible plants are found very useful in the fulfilment of food and nutritional requirements. Because of the availibity and cultural preference, the consumption of these plants among the tribes is high. To find out the diversity, utilisation pattern and sociocultural importance of the wild plants, a study was conducted in the state of Arunachal Pradesh selecting the Galo tribe, and accordingly the wild edible plants consumed are documented here. Data were collected through extensive field surveys and interviews with the community in the selected 12 villages in Upper Subansiri and West Siang districts of Arunachal Pradesh. Overall, 125 wild edible plant species under 99 genera and 54 families are reported. These species are consumed mostly as leafy vegetables, fruits, medicine, spices and condiments and as a substitute to food grains. The Urticaceae with ten species is the most utilised family followed by Asteraceae, Moraceae and Lamiaceae with at least five species in each. Herbs with 47 species were found to be the most dominant growth form followed by trees with 44 species. Based on parts used leaves with 66 species were recorded to be the most used plant parts followed by fruits. The highest edibility index of 50 % was reported in Solanum americanum. The analysis of relative frequency of citation revealed that total 78 species exhibits more than 0.50 relative frequency of citation value with highest value in Pouzolzia hirta (0.95). It has been found that the wild plant resources play a vital role in the socio-economic aspects of the Galo tribe.
Phytoconstituents, extraction and analysis of chemical compounds of Crataegus pontica K.Koch fruit using HS-SPME and GC-MS methods
Authors: Bazgir Nasrin , Ghaysouri Abbas , Shakib Pegah , Shahsavari Somayeh
Published: October 2020

Essential oils were extracted by HS-SPME method from the fruit of the Crataegus pontica K.Koch collected from the southern regions of Ilam province. Then, to identify chemical compounds, the essential oil was injected into a chromatograph gas device connected to a mass spectrometer (GC-MC). Of the 50 compounds identified in this essential oil, beta-Thujene (17.21%), alpha-pinene (15.40%), 2-Hexenal (12.42%), trans-Caryophyllene (8.76%), beta-Myrcene (7.89%), 1-Pentadecene (5.89%), Sabinene (4.33%) and trans-beta-Farnesene accounted for %3.50 of the major fruit essential oil compounds of C. pontica.
Morpho-agronomic characters of oat growing with humic acid and zinc application in different sowing times
Authors: Kutlu Imren , Gulmezoglu Nurdilek
Published: October 2020

The objectives of the study were to determine the effects of humic acid (HA) and zinc (Zn) applications on winter tolerance and yield performance of oat (cv. Albatros) planted in winter and spring sowing times (ST). We conducted the study in the 2017/2018 growing season. The experimental layout was split-split plots with three replications. Sowing times (winter and spring) comprised of the main plots. Humic acid application (with HA and without HA) was in the sub-plots, and Zn application rates (0, 23 and 46 kg ha-1) were in the sub-sub-plots. Chlorophyll content of plants was measured at the heading stage, while plant height, panicle height, panicle weight, number of grain per panicle, weight of grains per panicle, harvest index and grain yield were determined at the harvest. The effects of HA and Zn applications in both ST increased the chlorophyll content, yield and yield components. The results showed that cold tolerance of oat plants can be increased by the application of HA and 46 kg ZnSO4.7H2O ha -1. Overall performance of winter season was better than spring; thus, oat can be cultivated in winter under warm winter climate conditions. In addition, the HA and Zn applications can be used for other cold sensitive plant species to increase the cold tolerance which is a prevalent environmental stress affecting productivity of crops.
New species and new records of the lichen genus Buellia sensu lato (Caliciaceae) from India
Authors: Ngangom Roshinikumar , Nayaka Sanjeeva , Gogoi Rupjyoti , Ingle Komal Kumar , Behera Prashant Kumar , Yasmin Farishta
Published: October 2020

While revising the lichen genus Buellia sensu lato from India, species Cratiria rubrum with brick red pigmented thallus is described as new to science. The new species is characterized by a red pigmented thallus, Buellia type ascospore, KOH+ red. Five species are reported for the first time from India viz., Amandinea efflorescens, A. incrustans, Baculifera orosa, Hafellia dissa and H. reagens.
Teachers’ self‐reported L1 and L2 use and self‐assessed L2 proficiency in primary EFL education
Authors: Wilden Eva , Porsch Raphaela
Published: October 2020

This study investigates teachers’ first language (L1, German) and second language (L2, English) use in the primary English as a foreign language (EFL) classroom in two federal German states. It particularly focuses on the question of whether a more frequent, (self-reported) use of the L2 is positively correlated to teachers’ professional qualification as well as (self-assessed) L2 proficiency. To this end, data was collected in 2017 through an online survey among German primary teachers teaching EFL in year 4 (N = 844). L2 use was assessed through a 4-point Likert scale comprising 16 items on various classroom situations. L1 use was surveyed with an open question on situations of L1 use in the L2 classroom. Moreover, teachers self-assessed their L2 proficiency with a 4-point Likert scale and adapted CEFR descriptors for speaking. Findings indicate that teachers claim to use the L2 more in L2-related situations and the L1 more in classroom management situations. The study shows that teachers with a higher formal qualification tend to assess their L2 proficiency higher and claim to use the L2 more often in the primary EFL classroom. In contrast, teachers with a lower formal qualification tend to assess their L2 proficiency lower and claim to use the L1 more frequently in the L2 classroom.
Gamification based learning activities in elementary Brazilian public school
Authors: Ferraz Júnior Wilton Moreira , Martinelli Suéllen Rodolfo , Santos Carlos Henrique da Silva , Homem Murillo Rodrigo Petrucelli
Published: October 2020

This work presents an iterative method which is based on the serious games development in elementary and high school classes, focusing on the students and teachers experiences from Brazilian scholar reality. Furthermore, it does not require strong background in game development and it is planned to be introduced any area of knowledge. It has been considered as a motivational method to engage the teachers and students’ in-depth discussions. It follows some Agile Methods practices, such as the Extreme Programming (XP) and Scrum Agile Methods to guide them along the continuous exploration of game design in classrooms. This method also considers the design patterns techniques to reuse (re-guise) some well-known digital games engines and educational concepts, as example a guided game design based on the spaceships battles to associate electric charges concepts. The results obtained in experiments occurred in public schools show successful acceptance and they contribute to improve the students’ academic performance. This method is now introduced in some undergraduate and graduate practices to analyze its impact in entrepreneurship courses.
The effects of Electronic Word of Mouth (eWOM) on the adoption of consumer eWOM information
Authors: Le-Hoang Phuong Viet
Published: October 2020

The purpose of this research is to explore and test the effect of electronic Word-of-mouth (eWOM) on the adoption of consumer eWOM information. Through the credibility variables of the eWOM, namely the trust of the eWOM news source, the quantity of eWOM, the quality of eWOM and consumer expertise in the case of female consumers when buying cosmetics in Ho Chi Minh City, Vietnam. To achieve this goal, the author does conduct research by submitting an online survey questionnaire and obtained 200 valid questionnaires. The online questionnaire has targeted internet users, who have previously purchased online and read reviews online received from the provider's website. The result from Exploratory Factor Analysis (EFA) shows that consumer expertise has the most significant effect on consumer adoption of eWOM information while the number of eWOM has the least impact. Besides, the credibility of eWOM news sources and the quality of eWOM also indirectly affect the adoption of eWOM information. What is more, the study suggests some recommendations to cosmetic businesses so that they develop applications or websites where assessments and quality of information are relevant, and the current expertise of consumers is increasingly present.
Control of the variability of the biofuel packaging process through the six sigma methodology: a case study
Authors: Júnior Walther Azzolini , Pianno Rafael Francisco Campos , Achcar Jorge Alberto
Published: October 2020

The present work carried out the control of the variability in the biodiesel packaging through the application of the steps of the DMAIC (Define Measure, Analyze, Improve and Control) of the Six Sigma quality program. The DMAIC method brings together a set of statistical and quality tools for the study of process variability. Prior to the project, in the period evaluated between June and October of the year 2017 the average monthly variation of loss was 387.7 liters with a standard deviation of 421.9 liters. After the implementation of the improvements between January and March of the year 2018, the average monthly variation was -3.187 liters with a standard deviation of 60.95 liters. This evolution in the control and reduction of losses in the container of biodiesel was possible through the actions of improvements and involvement of the people of the billing and shipping. After all the improvements implemented, the maintenance and continuity of the controls met two important requirements of the Six Sigma quality program: customer focus and financial impact.
Technology transfer and investments in brazilian public healthcare
Authors: Gomes Myller Augusto Santos , Kovaleski João Luiz , Pagani Regina Negri , Zammar Gilberto
Published: October 2020

This study’s objective is to understand the industrial and technological context involved in the offset policy and technology transfer developed in Brazilian public healthcare. Initially, the acquisition of linear accelerators for oncology treatments seemed to be a solution for the problem of long waiting lines in the Brazilian Single Health System (SUS - Sistema Único de Saúde), but the reality was different. Through the methodological procedure of a case study at a hospital renowned for its oncology treatments in the south of the country, it was possible to elucidate its ability to manage the public investment in relation to the industrial and technological context. The relevant findings show that, even with the limitations of the commercial agreement, the hospital at hand was able to, through knowledge, mitigate the difficulties of the offset policy and carry out the technology transfer with ease, due to its familiarity with the new technology. Through this analysis, based on the empirical context, it was possible to summarize the main benefits and setbacks that arise from the strategic and operational levels of the commercial agreement, both at its initial and final stages. This study hopes to spark new investigations on the topic in order to comprehend and intervene in different contexts and situations.
Replenishment and Maintenance of the Human Body (Timaeus77a–81e)
Authors: Schroeder Lea Aurelia
Published: October 2020

Scholarship on Plato'sTimaeushas paid relatively little attention toTim. 77a–81, a seemingly disjointed passage on topics including plants, respiration, blood circulation, and musical sounds. Despite this comparative neglect, commentators both ancient and modern have levelled a number of serious charges against Timaeus' remarks in the passage, questioning the coherence and explanatory power of what they take to be a theory of respiration. In this paper, I argue that the project of 77a–81e is not to sketch theories of respiration, circulation, and digestion (inter alia), but to explain how the human body is maintained in light of and despite constant environmental depletion. Further, I argue that in order to understand this account of “the replenishing system,” we need to understand Timaeus' striking analogy of the fish trap ornassa. Commentators have generally focused directly on the workings of the bodily construction that Timaeus likens to a fish trap, but without considering how we should understand the analogyquaanalogy. I develop a functional reading of the analogy that yields a coherent account of the replenishing system on which previous criticisms of Timaeus' remarks on respiration do not arise. Aside from lending greater unity to the passage, both internally and within its immediate context in the dialogue, this account of the replenishing system contributes to our understanding of Timaeus' reason-and-necessity explanatory framework as applied to the human body and has noteworthy implications for specific explanatory principles, in particular like-to-like motion and circular thrust.
Amine-functionalized magnetic activated carbon as an adsorbent for preconcentration and determination of acidic drugs in environmental water samples using HPLC-DAD
Authors: Akawa Mpingana Ndilimeke , Mogolodi Dimpe Kgogobi , Nomngongo Philiswa Nosizo
Published: October 2020

In the present study, a convenient and highly effective method was developed for the quantification of acidic drugs in wastewater and river water samples. Ultrasonic-assisted magnetic solid phase extraction employing magnetic waste tyre-based activated carbon nanocomposite functionalized with [3-(2-aminoethylamino)propyl]trimethoxysilane as a cost-effective and efficient adsorbent was used for the extraction and preconcentration of acidic drugs (naproxen [NAP], ketoprofen (KET) and diclofenac [DIC]). The quantification of target analytes was achieved by high‐performance liquid chromatography with diode array detector. Under optimum conditions, the detection limit, quantification limit and relative standard deviation obtained for the analytes of interest ranged from 0.38 to 0.76, 1.26 to 2.54 µg L−1 and 2.02 to 4.06%, respectively. The applicability of the developed method was assessed by the spike recovery tests and the relative recoveries proved that the method is reliable for the determination of acidic drugs in wastewater. Thereafter, the method was applied successfully for the determination of NAP, KET and DIC in river water, influent and effluent wastewater.
Tribological and nanomechanical properties of a lignin-based biopolymer
Authors: Broitman Esteban , Nedelcu Dumitru , Mazurchevici Simona-Nicoleta
Published: September 2020

A research is reported on the nanomechanics and tribology of the Arboblend V2 Nature biopolymer (a 100% bio-based material, biodegradable, or resistant depending of application), being a mixture of different biopolymers such as lignin, polylactic acid, cellulose, biopolyamides, and other natural additives. The specimens were made by an industrial-scale injection molding machine. The nanoindentation characterization have unveiled that an increase in processing temperature from 160°C to 170°C produces a rise in hardness and elastic modulus of ∼20%. Tribological characterization against a bearing-steel counterface has shown that for both processing temperatures, the increase of the applied load or the increase of sliding speed will produce an increase of the friction coefficient (µ) and wear. At an applied load of 1 N (contact pressure of 104 MPa) and tracks in a direction perpendicular to the surface textured lines, the lowest µ ∼ 0.148 are for samples made T = 170°C, while for tracks parallel to the textured lines, the lowest µ ∼ 0.059 is obtained for samples made at T = 160°C. Experiments made at different ambient humidity have established that friction coefficient is higher at 0% RH or at 75% RH than at 33% RH. Our results show that the biopolymers Arboblend V2 Nature is a candidate to substitute some popular fossil-based thermoplastics in numerous tribological industrial applications.
Inverse source problem for the abstract fractional differential equation
Authors: Kostin Andrey B. , Piskarev Sergey I.
Published: September 2020

In a Banach space, the inverse source problem for a fractional differential equation with Caputo–Dzhrbashyan derivative is considered.
The initial and observation conditions are given by elements from

D
⁢

(
A
)

{D(A)}

, and the operator function on the right side is sufficiently smooth.
Two types of the observation operator are considered: integral and at the final point.
Under the assumptions that operator A is a generator of positive and compact semigroup the uniqueness, existence and stability of the solution are proved.
Conversion of sub-µm calcium carbonate (calcite) particles to hollow hydroxyapatite agglomerates in K2HPO4 solutions
Authors: Yanyan Sun , Guangxin Wang , Wuhui Li , Yaming Wang , Hayakawa Satoshi , Osaka Akiyoshi
Published: October 2020

Sub-µm CaCO3 (calcite; CC) particles were converted to calcium monohydrogenphosphate dihydrate (DCPD) and hydroxyapatite (HAp) via soaking treatments in K2HPO4 solutions with varied pH (3–12) and concentrations (0.1–1.5 M) at 37°C for up to 10 days. DCPD was derived from the solutions with pH ≤ 6; while hollow HAp was yielded when pH ≥ 7 in assemblies of petal-like crystallites. Results of magic angle spinning (MAS) and cross-polarization magic angle spinning (CP-MAS) NMR studies have shown that the HAp lattice has only PO4
2− but no HPO4
2− at B (phosphate) sites. Trace amounts of CO3
2− have occupied both A (OH) and B (PO4) sites, and H2O is adsorbed on surface crystallites. The primary crystallite size of HAp derived from Scherrer equation increases quickly in a 12 h period and becomes gradually stable afterward. Samples of particles soaked within 3 h in a temperature range of 20–80°C were analyzed by X-ray diffraction. It is shown that the rate constant of 1 M solution is about an order of magnitude greater than that of 0.1 M solution and the apparent activation energy is 33 kJ/mol. In this work, the conversion of CC to HAp can be quantitatively controlled to solve the problem of slow degradation of HAp.
Wearable robotic exoskeletons: A socio-philosophical perspective on Duchenne muscular dystrophy research
Authors: Kapeller Alexandra , Nagenborg Michael H. , Nizamis Kostas
Published: September 2020

Recently, several research projects in the Netherlands have focused on the development of wearable robotic exoskeletons (WREs) for individuals with Duchenne muscular dystrophy (DMD). Such research on WREs is often treated solely within the disciplines of biomedical and mechanical engineering, overlooking insights from disability studies and philosophy of technology. We argue that mainly two such insights should receive attention: the problematization of the ableism connected to the individual model of disability and the stigmatization by assistive technology. While disability studies have largely rejected the individual model of disability, the engineering sciences seem to still locate disability in an individual’s body, not questioning their own problematization of disability. Additionally, philosophy of technology has argued that technologies are not neutral instruments but shape users’ actions and perceptions. The design of WREs may convey a message about the understanding of disability, which can be comprehended as a challenge and an opportunity: stigmatization needs to be avoided and positive views on disability can be evoked. This article aims to highlight the benefits of considering these socio-philosophical perspectives by examining the case of WREs for people with DMD and proposing design principles for WREs. These principles may enhance acceptability of WREs, not only by individuals with DMD but also by other users, and help engineers to better place their work in the social context.
The (Mixed) Effects of Minimum Asset Requirements When There is a Possibility of Technological Change
Authors: Jacob Julien
Published: October 2020

Civil liability and ex ante authorizations are usually combined to regulate risks from high-risk industries. Authorizations may require firms to be sufficiently endowed with assets. Such a requirement is made in order to force sufficient risk internalization by firms, thus ensuring optimal decisions on risk control. But most studies on the incentives provided by asset requirements for controlling risks have been conducted in a context of a unique technology of production. When the firm has the possibility of adopting new and more cost-efficient technology, we show that tightening the minimum asset requirement can have a non-monotonic effect on the firm’s technological choice: increasing the firm’s level of assets can lead to a divergence of private and social interests as regards the technological choice. This feature can be observed both when the level of harm is dependent on, or independent of, the level of activity.
The Psychodynamic Psychiatrist and Psychiatric Care in the Era of COVID-19
Authors: Ingram Douglas H. , Best Kimberly
Published: September 2020

Near the beginning of the COVID-19 pandemic, on April 13, 2020, about 50 members of the American Academy of Psychodynamic Psychiatry and Psychoanalysis convened through Zoom to talk about the impact of the pandemic on their practices, their patients, and themselves.* They offer their reflections through oral and written comments. Participants were encouraged to organize their contributions around the dimensions of administrative psychiatry, the structure of clinical care, the content of clinical care, the patients’ reported personal experiences, and the psychiatrists’ reported personal experiences. Themes identified and discussed are paradoxical separateness, seeking an optimal interpersonal distance, finding new idioms, reality and symbolism, and loss, mourning, and isolation. The views are noted to touch on only one point early in the arc of the pandemic. A significant body of personal commentary provides an understanding of the roots of themes likely to evolve as the pandemic progresses.
A Psychiatric Residency in the Era of COVID-19: A Bionian Perspective
Authors: Lim Christopher T. , Harris Zachary B. , Caan Marissa P.
Published: September 2020

Coronavirus disease 2019 (COVID-19) is currently ravaging health systems across the world. Psychiatric trainees are at risk of exposure to patients with COVID-19 given their clinical roles in emergency and inpatient psychiatric settings. This article represents a case study of group dynamics in which we reflect on our own experience as psychiatric residents at a Boston-area hospital system in the era of COVID-19 and apply Wilfred Bion's concepts of the “work group” and the “basic assumption group” processes of group operation. We assess dynamics between trainees and administrative leadership both at baseline and in the current pandemic. Since navigation through crises is more effective if group leadership recognizes and responds to basic assumption behaviors, we propose suggestions to enable health system administration to successfully lead health care organizations through periods of societal turmoil. We posit that these principles apply across settings, specialties, and provider types. In addition, we use our observations to indicate future directions for expanding Bion's theories in the contemporary context.
Design of spline surface vacuum gripper for pick and place robotic arms
Authors: Jamaludin A. S. , M. Razali M. N. , Jasman N. , A. Ghafar A. N. , A. Hadi M.
Published: October 2020

The gripper is the most important part in an industrial robot. It is related with the environment around the robot. Today, the industrial robot grippers have to be tuned and custom made for each application by engineers, by searching to get the desired repeatability and behaviour. Vacuum suction is one of the grippers in Watch Case Press Production (WCPP) and a mechanism to improve the efficiency of the manufacturing procedure. Pick and place are the important process for the annealing process. Thus, by implementing vacuum suction gripper, the process of pick and place can be improved. The purpose of vacuum gripper other than design vacuum suction mechanism is to compare the effectiveness of vacuum suction gripper with the conventional pick and place gripper. Vacuum suction gripper is a mechanism to transport part and which later sequencing, eliminating and reducing the activities required to complete the process. Throughout this study, the process pick and place became more effective, the impact on the production of annealing process is faster. The vacuum suction gripper can pick all part at the production which will lower the loss of the productivity. In conclusion, vacuum suction gripper reduces the cycle time about 20%. Vacuum suction gripper can help lower the cycle time of a machine and allow more frequent process in order to increase the production flexibility.