bluuebunny/crossref_metadata_2025 huggingface dataset:
Penerapan Elektronik Customer Relationship Management (E-CRM) Dalam Penjualan Roti Berbasis Web
Authors: Ariska Anggi Mela , Irawati Novica , Muhazir Ahmad
Published: October 2022

UD Roti Ali is a home industry engaged in the production of bread making. The rapid development of technology in the world has had a major influence on the performance of bread making in all business fields, especially in the food manufacturing business. The business strategy of retaining old customers is more profitable than finding new customers, so it is necessary to maintain relationships with customers. UD Roti ali does not yet have a strategy to get new customers to find out information about products and prices. Currently UD Roti Ali does not yet have the right relationship with customers, one of which is the sales and ordering process is still done manually, where customers directly come to UD Roti Ali or call to place an order for products, then recording customer order data is still done by recording in the memorandum, so errors often occur in recording customer order data. This affects the bakery business, so UD Roti Ali needs an electronic system using the CRM method to build and manage the right relationship between UD Roti Ali and its customers. Therefore, UD Roti Ali needs a special strategy regarding proper customer service and product marketing in electronic form using a web-based CRM (E-CRM) method which is useful for making it easier for UD Roti Ali and customers, for UD Roti Ali it is easier to manage sales data and customer data, while for customers it is easier for customers to find out information about products, make it easier to make orders, payments, as well as the discount/promo and bonus features provided by UD Roti Ali to customers. So that this web-based system can help UD Roti Ali in maintaining customer loyalty.
Desain Interkoneksi Jaringan Menggunakan Vpn Internet Untuk Mendukung Sistem Pemerintahan Berbasis Elektronik
Authors: Subidin Yayan Candra , Antoni Darius
Published: October 2022

The rapid advance in information and communication technologies developement has greatly facilitated the development of electronic government worldwide. This can be seen from the various applications of information technology in government agencies, including integrated Electronic-Based Government System (SPBE). Numerous government agencies have implemented SPBE services for their daily operations. However, there are not infrequently the initiative for the existence of ICT infrastructure in several government institutions has some issues because due to various aims and backgrounds in developing it. The issues such, development of ICT network infrastructure is less efficient and effectiveness, the absence of a standard network system configuration, and the network security system underestimated. Therefore, this research will be designed and built ogan komering ulu regency government network systems using IPv4-based internet VPN with Network Development Life Cycle (NDLC) method. The purpose of this research is to provide a model of uniformity in the preparation of government network configurations, realize network interconnection between government agencies that make better utilization of network infrastructure, and support SPBE in Goverment of Ogan Komering Ulu District and improve aspects of network security in government. The results of this study indicate that by using a VPN network interconnection design, private network communication that passes through the public network (internet) will be more secure so that data confidentiality is maintained. The quality of data exchange in the form of images, sound, and text is better with a stable speed and maintained security. The use of IPv4 for network interconnection is used to reach all government agencies in the Scope of Government of Ogan Komering Ulu Regency.
Comparative Analysis of Multinomial Naïve Bayes and Logistic Regression Models for Prediction of SMS Spam
Authors: Raharja Pradana Ananda , Sidiq Muhammad Fajar , Fransisca Diandra Chika
Published: October 2022

This research was conducted based on a report from the United States Federal Trade Commission regarding fraud through electronic text messages via SMS that fraudsters use to manipulate potential victims. Usually, scammers spread SMS spam as an intermediary for the crime. The development of a supervised learning algorithm is applied to predict SMS spam into three categories, such as SMS spam, SMS fraud, and promotional SMS. The prediction system is dividing into several stages in the development process, including data labelling, data preprocessing, modelling, and model validation. The known accuracy based on modelling using Logistic Regression using a test size of 15% is 99%, using a test size of 20% is 99%, and using a test size of 25% is 98%. The Multinomial Naïve Bayes algorithm's accuracy with a test size of 15%, 20%, 25% is 97%. So, the SMS spam prediction approach uses the logistic regression method, which has the highest accuracy.
Penerapan Metode Dempster Shafer Untuk Diagnosa Penyakit Batu Karang
Authors: Sari Vina Winda , Zunaidi Muhammad , Nasyuha Asyahri Hadi , Marsono Marsono
Published: October 2022

Rocks or urinary tract stones are small and hard deposits that form in the kidneys, urinary tract and often cause pain when urinating, due to lack of public knowledge about the problem of coral disease, and to find out about this situation, people usually do an examination at the home. Sick or Doctor. However, not everyone can do this, this can be due to insufficient economic factors or long distances to visit the doctor, there are also weaknesses in the limited working hours of the doctor's practice. Therefore, innovations and solutions are needed in these conditions, namely by utilizing computer technology to build an expert system that has the ability as a doctor in making diagnoses. This study aims to create an expert system analysis with the Dempster Shafer method that can help doctors and physician assistants, or the general public in diagnosing coral stone disease. The results of this study indicate that with the analysis of the Dempster Shafer method, more optimal and accurate diagnostic results related to coral disease are available to the general public and can assist in the examination of coral disease.
Penerapan Metode VIKOR (Visekriterijumsko Kompromisno Rangiranje) dalam Pengambilan Keputusan Pemilihan Emulator Android pada Komputer
Authors: Sari Renny Pusita , Susanti Meilia
Published: October 2022

This research is a research on a decision support system in choosing the best android emulator to use on a computer as a topic of discussion. The Android emulator is a software that supports computers, both laptops and other computer devices, to be able to continue to access Android in computer use by simulating Android to a computer device. In choosing an android emulator, problems often arise to use which emulator is the best and in accordance with the specifications of the computer you have, so for this conditioning, emulator experiments must be carried out one by one in an effort to ensure which emulator is of the highest quality and in simulating android on. Decision Support System can be a good approach in selecting an android emulator, with several criteria in determining the best android emulator, the VIKOR method is used because it has a multi-criteria basic concept. The VIKOR method is an approach in ranking alternatives to get the ideal and best solution with the criteria that have been owned and determined. In testing by managing data, it was found that the genymotion emulator had a final result of 0 and became the best emulator. By applying the VIKOR method, android users or emulator seekers, namely the community of game lovers or gamers, and android lovers will help to determine the ideal android emulator according to the specifications and the best emulator quality.
Market Basket Analysis Menggunakan Association Rule dan Algoritma Apriori Pada Produk Penjualan Mitra Swalayan Salatiga
Authors: Umar Elfira , Manongga Danny , Iriani Ade
Published: October 2022

Market Basket analysis is learning to manage associations in data processing in various fields. The main purpose of Market Basket analysis in the field of sales is to convey an important message to the company so that it can find out the behavior patterns of entering goods into the shopping basket by consumers so that partners can make a decision. In this study, the Apriori Algorithm is used to take into account changes that occur in the data. This study discusses data mining techniques in analyzing what items are most often purchased at the same time by consumers so that they can change the placement of items that are close together to increase the impulse buying effect. The results obtained are 5 rules where one of the rules obtains the highest confidence value when buying cigarettes, the dominant item is taken simultaneously, namely eggs by obtaining a confidence value that can meet the highest confidence requirements, namely 67%.
Perbandingan Metode Naïve Bayes dan Support Vector Machine Untuk Analisis Sentimen Terhadap Vaksin Astrazeneca di Twitter
Authors: Indriyani Eva Rahma , Paradise Paradise , Wibowo Merlinda
Published: October 2022

The implementation of Covid-19 vaccination in Indonesia turned out to have various pro and contra opinions from the public. The discovery of disinformation and misinformation about vaccines  spread through social  media content affects a person's absorption of information so which leads to vaccine delays. When in fact, vaccination is one of the biggest and most effective contributions  to preventing the Covid-19 pandemic. Astrazeneca is one of the vaccines provided by the Indonesian government. This vaccine used to be controversial amongst the public regarding its halalness and the safety of the vaccine because of the issue of  the said vaccine  containing swine trypsin. Nowadays Twitter has  become a place for users to express their concerns and opinion regarding the Covid-19 vaccine. Data obtained from Twitter will be useful if it is analyzed, one of which is sentiment analysis. In this study, data collection was carried out using the snscrape library with a total of 3105 tweets obtained from the  period May to June 31, 2021. The dataset that has been  collected is then  preprocessed to optimize the data. After passing the preprocessing stage, the data was labeled as tweet class using a lexicon-based dictionary which resulted in 1275 tweets with positive opinin labels and 1830 tweets  labeled as negative opinion. The  aim of this study is to examines the performance of Naïve Bayes and Support Vector Machine with  adding the weighting method  TF-IDF (Term Frequency – Inverse Document Frequency). The evaluation results  show that the Support Vector Machine has a greater accuracy, precision, recall and f1-score of 87.27%, 90.41%, 77,34% and 83.37% compared to  Naïve Bayes which has an accuracy, precision, recall and f1- of 76.81%, 72.40%, 70.70% and 71.52%.
Sistem Pendukung Keputusan Penentuan Profesi Mahasiswa Informatika Menggunakan Metode WP-RIASEC
Authors: Taufik Raihan Aqila , Rosyda Miftahurrahma
Published: October 2022

Informatic Program in Ahmad Dahlan University engaged in the field of informatics/computer science. At the Informatic Program in Ahmad Dahlan University, there are still many students who are confused when they want to decide which profession to pursue when they graduate. This is based on a questionnaire distributed to final semester students from the Informatics Program in Ahmad Dahlan University. From the distributed questionnaires, the results of the questionnaire were obtained, namely more than 50 percent of respondents were still confused in determining the professional field to be occupied when they graduated. In addition, in an interview conducted with a psychologist, he said that personality is very influential on a person's work. To help Ahmad Dahlan University Informatics Students in determining a profession, a decision support system was created that can help students of the department in determining the appropriate professional field based on the value of the course and their personality. The method used in this research is WP and RIASEC. The WP method plays a role in calculating the weight of each course value. While the RIASEC method plays a role in determining a person's personality which is the basis for determining appropriate professional alternatives based on their personality. The results of system testing that have been carried out on 10 respondents consisting of 7 students and 3 alumni from the Informatics Program in Ahmad Dahlan University have obtained test results with a value of 84.5, which means the system is running well and meets the existing standards.
Penerapan Business Intelligence Terhadap Data Penjualan UMKM (Foodendez) Menggunakan Metode Algoritma Apriori Dalam Menentukan Segmentasi Pasar
Authors: Oktavian Akhmad Rafi , Rumaisa Fitrah
Published: October 2022

MSMEs in Indonesia are MSMEs with a business scale level of 98.7% are micro-enterprises and this MSME-scale assessment category was assessed or researched 10 years ago, the results are still the same as the previous assessment, due to the average MSMEs in Indonesia not having a way or the right innovation in developing its business, especially in terms of the products produced and other things, an example of MSMEs experiencing this is MSME Foodendez, which causes these MSMEs to not have significant sales progress. Therefore, to improve the quality and progress of the Foodendez MSME business, the current sales data is used to recapitulate and evaluate the Foodendez MSME market segmentation. By using the a priori algorithm, the sales data can be used to find out predictive information on consumer interest based on age, gender, and sales location criteria. The application of business intelligence uses an a priori algorithm so that it can help provide predictive information on consumer interest in a product and can clearly know its market segmentation by collecting data through product sales in the marketplace it can be seen which products are most interested in by consumers, then data on the amount followers, comments, and likes in every post on social media in order to determine engagement (promotional strategies through social media). In this research, testing is carried out based on the location of sales at Foodendez SMEs so as to produce market segmentation data. The conclusion from the temporary test results, the frequency of sales in the marketplace is the highest at 52%, then the lowest frequency of sales is 12% in sales through exhibition bazaars.
Analisa Efektifitas Kebijakan PPKM terhadap Pertumbuhan Kasus COVID-19 Menggunakan Algoritma Naïve Bayes
Authors: Hayami Regiolina , Fatma Yulia , Antoni Okta Tri , Mukhtar Harun
Published: October 2022

The pandemic that is being experienced by Indonesia, namely the outbreak of the COVID-19 virus, has led to the implementation of large-scale social restrictions in order to accelerate the handling of the spread of the virus. As a result of the increasing number of COVID-19 cases in Indonesia, including in Riau Province, where every City and Regency has increased, especially Pekanbaru, the implementation of Community Activity Restrictions (PPKM). This study tries to answer this question by using the Naïve Bayes Algorithm. Naïve Bayes Classifier is a probabilistic and statistical method of classification technique that predicts future opportunities based on previous experience. The use of the Naïve Bayes algorithm to predict the growth of Covid-19 cases in Pekanbaru obtained a good performance score with 90.00% accuracy, 90.24% precision and 91.90% recall. Based on the results of the classification of the datasets used in this study, it can be concluded that the implementation of the Policy for Enforcement of Community Activity Restrictions (PPKM) in the city of Pekanbaru has proven to be effective where there has been a decline in the category of growth of Covid-19 cases with a high category from 70% to 25%. Vice versa, the growth of Covid-19 cases in the low category has increased from 30% to 65%.
Evaluation and Recommendation User Interface of Batamnews Based on User Experience using User-Centered Design
Authors: Kusuma Angelino Sandy , Sardi Indra Lukmana , Riskiana Rosa Reska
Published: October 2022

Batamnews is a media that presents news about Batam. Batamnews currently has an application that aims to make it easier for users to continue to be updated regarding news in Batam. But from the results of interviews and the distribution of questionnaires with Batamnews users, there are problems experienced by application users due to the User Interface which makes users uncomfortable using the application. Users feel that Batamnews is not optimal in terms of appearance, and the user's uninterested use of icons (symbols). In addition, Users complain about features that should be available but not in the app. Therefore, this study aims to make a design using the User-Centered Design (UCD) method because UCD focuses on user needs. Then for testing the design, the System Usability Scale (SUS) evaluation method will be used because it can be measured for effectiveness, efficiency, and satisfaction from users. The results of this study are recommendations for the User Interface Design of the Batamnews application and have an increased value on usability from 54 to 74 which is expected to be a reference for Batamnews application developers. So, it can be concluded that the UCD method can increase the SUS usability value in an application as well.
Динамика и факторы производства зерна в южных областях ЦФО
Authors: Макаров Вячеслав Иванович
Published: October 2022

Обоснована необходимость объективного анализа состояния основополагающих отраслей сельского хозяйства. Отмечена первостепенная роль зернового хозяйства в обеспечении продовольственной безопасности. Оценено место Центрального федерального округа (ЦФО) в структуре производства зерна в России. Выделен основной ареал возделывания зерна в округе. Проанализирована динамика производства зерна в черноземной зоне ЦФО. За последние 20 лет выявлен существенный рост среднегодового валового сбора, его прирост по пятилеткам. На основе применения статистического метода — индексный анализ — определены наиболее важные факторы объемов производства зерна в южных областях ЦФО. Отмечено влияние фактора «размер посевной площади» на рост объемов производства зерна в разрезе пятилетних периодов. Проанализирована структура посевной площади под зерновыми культурами. Выявлен наибольший удельный вес посевной площади под озимой пшеницей. Отмечено увеличение в процентном соотношении площади возделывания яровой пшеницы. В относительном исчислении определено влияние фактора урожайности на объем производства с использованием индексов урожайности и посевных площадей. Изучение пятилетних периодов позволило также установить абсолютный прирост в среднем за каждые 5 лет. Отмечена положительная динамика доз внесения минеральных удобрений в перерасчете на 100 % питательных веществ в расчете на 1 га. На основе корреляционного анализа показана высокая роль уровня внесения минеральных удобрений в повышении урожайности зерновых культур.
Parametric synthesis of car suspension
Authors: Aleksandrov Evgeniy , Shapovalenko Vladyslav , Baidala Vladyslava
Published: October 2022

Problem. When driving a vehicle with comfortable suspension settings, there is a high probability that such adjustments may, firstly, cause discomfort to the driver and passengers, and secondly, when cornering, there is a high probability that the vehicle will overturn. A stiffer suspension leads to discomfort when driving on bumps. To choose the optimal parameters of the car's suspension, it is necessary to take into account the various parameters of the car's suspension, its settings and the features of the road surface. Goal. Solving the problem of choosing the values of the varied parameters of the car suspension - the coefficients of stiffness of the elastic elements and the average values of the damping coefficients of the shock absorbers, which provide a comfortable state of the driver and passengers while driving. Methodology. The approaches adopted in the work to solve the problems are based on the algorithmic method of parametric synthesis of dynamic systems. Results. The obtained maximum values of generalized coordinates, speeds and accelerations of the sprung part of the car body, as well as the minimum values of functionalities, with the help of ratios are possible to estimate the values of weights of additive functionality based on MathCAD software package. With the help of the algorithmic method of solving the problem of parametric synthesis of a dynamic system it is possible to it automate. Analysis of the process with the specified coefficients allows to detect high efficiency of damping of vertical oscillations of the under-sprung part of the car body. The amplitude of the linear displacement of the center of mass of the body does not exceed 0,02 m, and the amplitude of the generalized veloc-ity of the centre of mass of the sprung part of the housing does not exceed 0,08 m/s-1. Originality. The obtained parameters allow to minimize the time for selection of average values when designing the vehicle suspension. Practical value. The results can be recommended when studying the design features of vehicle suspensions. Thanks to the optimization of the MATLAB software package, modeling with different suspension parameters is possible.
Regarding the issue of determining the deceleration of a two-axle vehicle with a damaged brake system
Authors: Leontiev Dmytro , Klymenko Valeriy , Aloksa Mykola , Sylchenko Mykola
Published: October 2022

Problem. During the study of the circumstances of the occurrence of road floors, the experts of the automotive technical expertise have a question about the choice of mathematical model for determining the deceleration of a two-axle vehicle with a faulty working brake system. The search for a universal method for calculating the amount of deceleration of a two-axle vehicle with a faulty working brake system is an urgent scientific task that will expand the understanding of the physical processes on which the provisions of the theory of the car are based. Goal. The aim of the work is to generalize theoretical research to determine the deceleration of a two-axle vehicle with a faulty working brake system. Methodology. The approaches adopted in the work to solve this goal are based on the analysis of methods for determining the deceleration of two-axle wheeled vehicles. Results. The obtained calculated values of deceleration of a two-axle wheeled vehicle with different external factors allowed to establish the features of the use of different methods in the practice of automotive technical expertise. It is established that taking into account the angle of the road surface towards the roadside and taking into account the coefficient of resistance of car tires can change the amount of deceleration of a two-axle wheeled vehicle with a faulty service brake system. Originality. The proposed universal method for determining the deceleration of a two-axle wheeled vehicle with a faulty working brake system, allows to take into account the influence of rolling resistance of tires and the angle of inclination of the road surface towards the roadside when studying the circumstances of a traffic accident. Practical value. The results obtained can be recommended in the practice of automotive technical expertise or in research related to determining the braking performance of two-axle wheeled vehicles.
Acceptability of Pennisetum purpureum by West African dwarf rams as influenced by manure application rates
Authors: WİLLİAMS Toyese , OJO Victoria
Published: October 2022

The present study evaluated the chemical composition and acceptability of Pennisetum purpureum by West African dwarf (WAD) rams as influenced by manure application rates. The experiment was a completely randomized design replicated three times. Grasses that have been fertilized with 5 and 10 t ha-1 of swine manure and unfertilized (control (0 t ha-1)), were harvested from the experimental site 9 weeks after planting from 15 cm above ground level and evaluated for proximate and fibre composition. The harvested grasses were also offered to nine WAD rams on cafeteria basis, to assess the acceptability indices of the grass based on treatments. Results showed that the grass with manures consistently had higher (p<0.05) crude protein (CP) contents than the control (unfertilized plants) while all the grasses with different manure rates had similar (p>0.05) neutral detergent fibre (NDF). Consumption, co-efficient of preference and relative palatability of P. purpureum by WAD rams were improved by manure application, where highest values of acceptability indices was recorded in grass with manure rate of 5 t ha-1 over 10 t ha-1 manured grass. Percentage consumption, co-efficient preference and relative palatability index were in the order 5 t ha-1 > 10 t ha-1 > 0 t ha-1 (unfertilized). From the result, it can be concluded that P. purpureum with manure had a better chemical composition profile (higher CP) and better acceptability than unfertilized grass. Enhancing P. purpureum with manure at 5 t ha-1 had higher ash content and improved acceptability by WAD rams than grass with 10 t ha-1 manure application rate.
The Importance of the Exceptional in Tackling Riddles of Consciousness and Unusual Episodes of Lucidity
Authors: Nahm Michael
Published: October 2022

The problem of how biochemical processes in the brain give rise to conscious experience is still unanswered. This paper aims at stimulating the debate surrounding this enigma by advocating the study of unusual and anomalous aspects of consciousness. For this purpose, the contents of this paper are organized in three parts. In the first part, I provide a brief overview on unsolved riddles of the mind. These include unusual episodes of lucidity that have been termed terminal lucidity and paradoxical lucidity. Because the use of these terms has sometimes been inappropriate in recent literature, I clarify the basic meanings of these two concepts in the second part. The third part contains suggestions for future research. Specifically, I argue that the field of studies into episodes of lucidity in dementias and the field of studies into end-of-life experiences, such as near-death visions, should engage in an active dialogue in order to build bridges between these disciplines. Such a dialogue will enable a better understanding of the whole spectrum, and thus, possible circumstances, causes and underpinnings of lucid episodes. In sum, this paper argues that the study of lucid episodes such as terminal lucidity, paradoxical lucidity, and related occurrences holds enormous significance for improving our understanding of brain functions and accompanying states of consciousness – from a practice-orientated perspective in the contexts of the dementias and dealing with end-of-life experiences, and from a theoretical perspective in the context of the scientific debate about the nature of consciousness.
Brenda J. Dunne (1944-2022)
Authors: Mertz Herb
Published: October 2022

Obituary for Brenda J. Dunne
Differential expression of P4HA3 in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: October 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of P4HA3, encoding prolyl 4-hydroxylase subunit alpha 3, in induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. P4HA3 was also differentially expressed in the skeletal muscle of patients with ALS. P4HA3 transcript was present at significantly lower levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
“Killing the Golden Goose?”: FDI in Poland 2022
Authors: Hunter Richard J. , Lozada Hector R.
Published: October 2022

This article is a follow up on recent events that relate to participation in foreign direct investment (FDI) activities in Poland in light of the Law on Freedom of Economic Activity (LFEA), the Act on Control of Certain Investments and the Amendments thereto, which provide for the rules on foreign participation in the Polish market and later restrictions on the purchase of Polish assets by discrete categories of investors. The article builds on research published in 2021 relating to the existence and importance of FDI in the Polish economy that had been negatively affected by a series of challenges and paradoxes in Polish society.
Young Learners Preferences on Using Games and Songs for Learning English in EFL Context
Authors: Budianto Suhartawan , Sayidah Nur , Sucipto  , Mustofa Amirul
Published: October 2022

This study investigated young learner preference for using games and songs to learn English in the EFL context. Many ways have been found to assist young learners in acquiring English as a Foreign Language. The students’ perceptions were taken from the questionnaire. The result showed that most students liked it better when the teachers used games and songs in teaching English in an EFL context. It is suggested that both games and songs can be utilized in teaching English to young learners in the EFL context.
VersatileEducationDomains ofSchools,Colleges andUniversities
Authors: Tahir Fatima
Published: October 2022

VersatileEducationDomains ofSchools,Colleges andUniversities
COVID-19 outbreaks in child care facilities Alberta from March 2020 to December 31, 2021
Authors: Geary Janis , Rudko Sydney P. , Scott Allison
Published: October 2022

Background: Children attending child care are vulnerable to SARS CoV-2 infection, and mitigationmeasures like masking, distancing, enhanced hygiene are not feasible for this population. Describingoutbreak growth during the COVID-19 pandemic in child care centres may provide insight in how to bestmitigate the risks of COVID-19 and other infectious diseases in these settings.Objective: To describe the characteristics of child care outbreaks and associated cases in Alberta.Methods: Our observational study used data on outbreaks and associated cases tracked through theAlberta Health Services Communicable Disease Outbreak Management database. We included allCOVID-19 outbreaks opened in child care facilities in the province (March 2020 to December 31, 2021).We compared the characteristics of outbreaks and cases during each wave of the pandemic.Outcome: 841 outbreaks were opened in Alberta, including 4613 cases (70.2% in children and 29.8%adults). Outbreaks averaged 5.5 cases per outbreak, and the average duration of time betweensymptoms starting in the first and last case was 9.7 days. The likely index was a child in 55.1% ofoutbreaks.Conclusions: Adults are a high proportion of cases compared to their proportion of the population atchild care facilities, and have consistently higher attack rates than children. Children have the highestattack rates when other children are the index case. Measures shown to be effective in other settings toreduce spread among adults can be implemented here, such as vaccination, strictly enforcing exclusionof those symptomatic, and facilitating rapid testing.
Differential expression of BIK in amyotrophic lateral sclerosis.
Authors: Mamoor Shahan
Published: October 2022

Neurodegenerative diseases that affect the motor neurons, including amyotrophic lateral sclerosis (ALS), have little treatment options and are generally rapidly fatal (1, 2). We harnessed the power of unbiased, whole transcriptome differential gene expression analysis, utilizing primary patient cells and tissues to discover genes whose expression defines ALS using published data (3, 4). We found significant differential expression of BIK, encoding BCL2-interacting killer, in the induced pluripotent stem cell (iPSC)-derived motor neurons of patients with ALS. BIK was also differentially expressed in iPSC-derived motor neurons in a separate microarray dataset (4). BIK transcript was present at significantly higher levels in ALS patient motor neurons as compared to control motor neurons. These analyses will begin to define the transcriptional landscape of ALS.
PASAR UANG SYARIAH
Authors: putri Aulia ananda
Published: October 2022

Pasar uang merupakan salah satu tempat surat-surat berharga jangka pendek diperdagangkan, yaitu kurang dari satu tahun dan transaksi pinjam meminjam dana (lending and borrowing) di antara pelaku pasar. Pasar uang merupakan tempat yang ideal bagi sebuah perusahaan ataupun institusi keuangan untuk menyimpan atau menginvestasikan surplus dana yang mereka miliki dalam periode tertentu
PASAR UANG SYARIAH
Authors: khasanah uswatun
Published: October 2022

perbedaan utama pasar uang dan pasar modal terletak pada jangka waktu, likuiditas, dan tingkat pengembalian dari suatu investasi, serta tempat dilakukannya transaksi. Pasar uang merupakan tempat perdagangan surat-surat berharga jangka pendek, yaitu di bawah satu tahun sedangkan pasar modal merupakan tempat perdagangan surat surat berharga dengan waktu jatuh tempo lebih dari satu tahun.?Fungsi pasar uang yang sangat berkaitan erat dengan dunia perbankan dan moneter merupakan fungsi likuiditas, fungsi sebagai wadah penyaluran kebijakan dan fungsi informasi.?Perbedaan mendasar antara instrumen pasar uang syariah dan konvensional, yaitu: Pada mekanisme penerbitan. Pada pasar uang konvensional, instrumen yang diterbitkan adalah instrumen utang yang dijual dengan diskon dan didasarkan atas perhitungan bunga, sedangkan pasar uang syariah lebih kompleks dan mendekati mekanisme pasar modal.?Pasar valuta asing merupakan suatu pasar yang memperdagangkan mata uang (valuta) suatu negara sebagai komoditas dan dipertukarkan dengan valuta asing negara lain atau dikenal dengan sebutan foreign exchange market (forex market). Berbeda dengan beberapa pasar keuangan lainnya, pasar valuta asing tidak mempunyai tempat transaksi khusus, seperti lantai bursa (trading floor) di pasar modal.
Holocene deglaciation and glacier readvances on the Fildes Peninsula and King George Island (Isla 25 de Mayo), South Shetland Islands, NW Antarctic Peninsula
Authors: Heredia Barión Pablo , Roberts Stephen , Spiegel Cornelia , Binnie Steven , Wacker Lukas , Davies Joanna , Gabriel Imogen , Jones Vivienne , Blockley Simon , Pearson Emma , Foster Louise , Davies Sarah , Roland Thomas , Hocking Emma , Bentley Michael , Hodgson Dominic , Hayward Chris , McCulloch Robert , Strelin Jorge , Kuhn Gerhard
Published: October 2022

To provide insights into glacier-climate dynamics of the South Shetland Islands (SSI), NW Antarctic Peninsula, we present a new deglaciation and readvance model for the Bellingshausen Ice Cap (BIC) on Fildes Peninsula and for King George Island/Isla 25 de Mayo (KGI) ~62°S. Deglaciation on KGI began after c. 15 ka cal BP and had progressed to within present-day limits on the Fildes Peninsula, its largest ice-free peninsula, by c. 6.6–5.3 ka cal BP. Probability density phase analysis of chronological data constraining Holocene glacier advances on KGI revealed up to eight 95% probability ‘gaps’ during which readvances could have occurred. These are grouped into four stages – Stage 1: a readvance and marine transgression, well-constrained by field data, between c. 7.4–6.6 ka cal BP; Stage 2: four probability ‘gaps’, less well-constrained by field data, between c. 5.3–2.2 ka cal BP; Stage 3: a well-constrained but restricted ‘readvance’ between c. 1.7–1.5 ka; Stage 4: two further minor ‘readvances’, one less well-constrained by field data between c. 1.3–0.7 ka cal BP (68% probability), and a ‘final’ well-constrained ‘readvance’ after <0.7 ka cal BP. The Stage 1 readvance occurred as colder and more negative Southern Annular Mode (SAM)-like conditions developed, and marginally stronger/poleward shifted westerly winds led to more storms and precipitation on the SSI. Readvances after c. 5.3 ka cal BP were possibly more frequent, driven by reducing spring/summer insolation at 62°S and negative SAM-like conditions, but weaker (equatorward shifted) westerlies over the SSI led to reduced storminess, restricting readvances within or close to present day limits. Late Holocene readvances were anti-phased with sub-aquatic moss layers in lake records unaffected by glaciofluvial inputs. Retreat from ‘Neoglacial’ glacier limits and the recolonisation of lakes by sub-aquatic moss in the post-bomb era (>1950 CE) is associated with recent warming/more positive SAM-like conditions.
Internal uncertainty impacts social information use in risky choice across adolescence
Authors: Ciranka Simon Kai , van den Bos Wouter
Published: October 2022

Peer influence plays a vital role in adolescents’ propensity to take risks. This is often explained by an adolescent-specific social sensitivity. However, uncertainty also leads people to be more susceptible to social influence. While researchers agree that adolescence is a time of great uncertainty, the role of uncertainty in explaining susceptibility to social influence across development is unclear because studies often do not distinguish internal uncertainty, being unsure about how to choose, from external uncertainty, a statistical feature of the environment. Doing so here, we asked 166 participants aged 10 to 26 to make 144 risky decisions in a lottery experiment, either with or without observing someone else's advice. We asked participants to decide based on described or experienced information about the lottery’s outcome probabilities, where external uncertainty is higher in the latter. Modelling susceptibility to social influence as Bayesian learning suggests that internal uncertainty diminishes linearly with age and contributes to decreasing susceptibility to social influence across adolescence. Our results imply that adolescent peer influence is not just a product of social sensitivity but also is driven by internal uncertainty about what to do.
Critical, Active, and Well-Adapted: Antecedents and Consequences of Adolescents’ Critical Consciousness Profiles
Authors: Schwarzenthal Miriam , Baysu Gulseli , Diemer Matthew , Juang Linda P. , Schachner Maja
Published: October 2022

This preregistered study aimed to identify antecedents and consequences of adolescents’ critical consciousness profiles via a person-centered approach among 663 ethnically diverse German adolescents (Mage= 12.91, 50% male, 50% female). Latent profile analyses of the adolescents’ critical reflection and interpersonal and structural critical action intentions yielded three profiles: “Uncritical”, “armchair activists”, and “actionists”. Discrimination experiences, but not critical consciousness classroom climate, predicted higher likelihood of being in the “armchair activist” or “actionist” profiles. Those in the “actionist” profile showed better, and those in the “armchair activist profile” worse socioemotional and academic adaptation cross-sectionally and over time (vs. “uncritical” ones). The results highlight the potential of person-centered approaches and of fostering developmentally appropriate forms of critical action among adolescents.
Not such a complainer anymore: Confrontation that signals a growth mindset can attenuate backlash
Authors: Rattan Aneeta , Kroeper Kathryn Mary , Arnett Rachel , Brown Xanni , Murphy Mary C
Published: October 2022

We report the first investigation of whether observers draw information about mindsets from behavior, specifically prejudice confrontation. We tested two questions across 10 studies (N = 3,168). First, would people who observe someone confront a biased comment (vs. remain silent) see them as endorsing more growth (vs. fixed) mindsets about prejudice and bias? If so, would the growth mindset perceptions that arise from confrontation (vs. remaining silent) attenuate the backlash that observers exhibit against confronters? We investigated these questions using scenarios (Studies 1, 2a-b, 4, 5a-d), naturalistic confrontations of national, race, and gender stereotypes reported retrospectively (Study 3), and an in-person laboratory experiment of actual confrontations of racial bias (Study 6). Correlational and experimental methods yielded support for our core hypotheses: People spontaneously imbue someone who confronts a biased comment with more growth mindset beliefs about prejudice and bias (Studies 1, 2a-b, 4, 6), regardless of whether participants observe the confrontation (Studies 1, 2a-b, 5a-d) or are being confronted themselves (Studies 2a-4, 6). The growth mindset perceptions arising from these confrontations suppress backlash, assessed by classic interpersonal perceptions (Studies 4-5) and judgments of interpersonal warmth and willingness to interact again in the future (Study 6), both when the confronter was a target of the biased behavior (Studies 1-5), and when they were an ally (Study 6), in both correlational studies (Study 3-4) and when growth mindset (about personality, Study 5; about prejudice, Study 6) was manipulated, confirming causality. We discuss implications for the study of mindsets, confrontation, and intergroup relations.
Poor air quality is associated with impaired visual cognition in the first two years of life
Authors: Spencer John P. , Forbes Samuel H. , Naylor Sophie , Singh Vinay P , Jackson Kiara , Deoni Sean , Kumar Aarti
Published: October 2022

Poor air quality has been linked to cognitive deficits in children, but this relationship has not been examined in the first year of life when brain growth is at its peak. We measured in-home air quality focusing on particulate matter with diameter of <2.5 μm (PM2.5) and infants’ cognition longitudinally in a sample of families from rural India. Air quality was poorer in homes that used solid cooking materials. Infants from homes with poorer air quality showed lower visual working memory scores at 6 and 9 months of age and slower visual processing speed from 6-21 months when controlling for family socio-economic status. Thus, poor air quality is associated with impaired visual cognition in the first two years of life, consistent with animal studies of early brain development. We demonstrate for the first time an association between air quality and cognition in the first year of life using direct measures of in-home air quality and looking-based measures of cognition. Because indoor air quality was linked to cooking materials in the home, our findings suggest that efforts to reduce cooking emissions should be a key target for intervention.
Cathelicidin LL-37 level in presence and absence of vitamin D in cultured macrophages isolated from elderly women
Authors:   Department of Dietetics & Nutrition, NSHM Knowledge Campus, Kolkata, West Bengal, India, Ghosh Joyeta , Chaudhuri Aditi Nag ,   Department of Microbiology, Lady Brabourne College, Kolkata, West Bengal, India, Saha Indranil ,   ICMR-Centre for Ageing & Mental Health, Indian Council of Medical Research, Salt Lake, Kolkata, West Bengal, India, Chaudhuri Debnath ,   Biochemistry and Nutrition Department, All India Institute of Hygiene & Public Health, Kolkata, West Bengal, India.
Published: October 2022

Introduction: Vitamin D deficiency and frequent infections are the two common worldwide phenomenon among elderly. Recent studies have demonstrated that vitamin D regulates the expression of specific endogenous antimicrobial peptides like cathelicidin LL-37 of macrophages and neutrophils, which is active against a broad spectrum of infectious agents. Therefore, the objective of the present study was to determine the level of cathelicidin LL-37 in macrophages of elderly women (classified according to serum 25(OH)D level) after exposure to Vibrio cholera infection and to find out the effect of 1,25(OH)2D added in vitro. Methods: This study was conducted among 40 randomly selected rural elderly women aged between 60 to 70 years of age. Their vitamin D status was assessed by the estimation of serum 25(OH)D and classified into three groups viz. sufficient (14 members), insufficient (13 members), and deficient (13 members). Later, their peripheral blood mononuclear cells (PBMC) were isolated and cultured from fresh blood. 1,25(OH)2D supplementation was given selectively at a dose of 10 ×10-8 M for 72 hours in the culture media; then exposed to infection and screened according to the objectives of this study. Results: Macrophages in all groups, except vitamin D deficient group, responded significantly in terms of LL-37 release during exposure to Vibrio cholera infection. Considering in vitro 1,25(OH)2D, supplementation responded significantly (p<0.05) in all three groups. Conclusion: Vitamin D can be used as a prophylaxis to enhance cathelicidin LL-37 release for all three groups as in the present study.
The Management of Katishoola (vertebral Compression fracture) through Panchakarma- A case study
Authors: Verma Poonam , Latika Dr. , Bhatted SantoshKumar
Published: October 2022

Background: In present era low backache (Katishoola) is a common complain among the patients visiting hospital for treatment. There are various causes for low backache like compression fracture, inter vertebral disc prolapse [IVDP], Lumbar spondylosis, tuberculosis of spine etc. About 39% of the population present complaints of low back pain at some point in their lives, Incidence is more in females aged between 40 and 80 years. vertebral compression fracture (VCF) are one of the cause of severe low backache. VCF is a common fracture of the spine. The symptoms of VCF are back pain, numbness, tingling, and weakness and intensity of pain increase while standing or walking. It can be correlated with Katishoola in Ayurveda. In contemporary science there is no treatment except some invasive procedure like vertebroplasty. Here in this case pain in lower backache associated with tingling sensation managed with Ayurveda Panchakarma treatment like Matra Basti, Katibasti, Pinda Swedana. The collected data shows that Panchakarma therapy along with oral medicine gave encouraging effect in low backache. Material and method: In this study the patient with complaint of pain in lower back, tingling sensation, unable to stand for long duration approached to the OPD of Panchakarma, AIIA hospital. He was managed with Panchakarma therapies along with oral medicines. Effect of treatment was assessed before and after the treatment on presenting complaints. Result and observation: Significant improvement was noticed after the treatment. Pain was reduced significantly. There was reduction in VAS scale, SLR, Marked improvement was noticed in Score of Oswestry low back pain index, Low back outcome score (LBOS). Discussion: In this case study we are focusing in the management of low backache due to wedge compression fracture through Ayurveda oral medicine along with Panchakarma to further deterioration of the condition of the patient.
Ayurvedic Management of Upanaha Induced Contact Dermatitis, a Type IV Delayed Hypersensitivity Reaction- A Case Report
Authors: Boruah Geetismita , M Ashvini Kumar , HR Nataraj , BA Lohith
Published: October 2022

Adverse drug reactions (ADR) are undesirable side effects of a pharmacological therapy that have a significant impact on an individual's quality of life. A 79-year-old female presented to the Panchakarma OPD of Sri Dharmasthala Manjunatheshwara College of Ayurveda and Hospital, Hassan, with complaints of itching, burning sensation, rash, and swelling in both knees for three days. She was diagnosed with an Upanaha induced contact dermatitis, specifically a Type IV delayed hypersensitivity reaction. The symptoms were completely resolved after a 15-day therapeutic strategy with Sudarshan Ghana vati, Laghusootshekhar rasa, and local application of Shatadhouta ghrita and Aloe Vera (Aloe Berdensis).