bluuebunny/crossref_metadata_2025 huggingface dataset:
Repair of Borderline Operable Atrial Septal Defect with Severe Pulmonary Hypertensionafter Medical Management
Authors: Nazrin T , Mansur M , Uddin Jalal , Shaha NC , Joarder MAR
Published: September 2014

Large left to right shunt across an atrial septal defect results in volume overload and dilatation of the right atrium and ventricle. As a result of increased flow into the lungs, the pulmonary arteries, capillaries & the veins are dilated & there can be flow related pulmonary artery hypertension. Overtime this can lead to medial hypertrophy of pulmonary arteries & muscularization of arterioles resulting in pulmonary vascular obstructive disease. Once PAH develops, it is challenging to determine operability and predict outcomes after repair in borderline situations. We report a woman with large atrial septal defect and severe pulmonary hypertension 9.84 wood units /m2 of indexed total pulmonary vascular resistance. She underwent successful corrective repair of atrial septal defect after 4 months of medical management. This case supports that careful evaluation of reversibility of borderline pulmonary arterial hypertension associated with atrial septal defect and pre operative medical management with advanced pulmonary vasodilator therapy can modify a life to normal following closure of ASD. DOI: http://dx.doi.org/10.3329/pulse.v6i1-2.20349 Pulse Vol.6 January-December 2013 p.44-47
Central Neurocytoma: a Case Report
Authors: Khaled A , Joarder MA , Chandy M , Nasir TA
Published: September 2014

Central neurocytoma is a tumour showing neuronal differentiation. This tumour usually located in ventricles occurs at young age and carries favorable prognosis. For this, accurate diagnosis is essential. There is no published case report of central neurocytoma in Bangladesh. With these objectives, we have presented a case report of central neurocytoma in a 37 years old female. DOI: http://dx.doi.org/10.3329/pulse.v6i1-2.20351 Pulse Vol.6 January-December 2013 p.51-52
Uterine Didelphys Associated With Obstructed Hemivagina and Ipsilateral Renal Anomaly (OHVIRA) Syndrome: a Case Report
Authors: Parvin A , Khan BS , Alam J , Ruby FA , Iqbal TJ
Published: September 2014

A 30 year old nulligravida female reported to the fertility centre of AHD with the complaints of primary infertility for three and half years and spasmodic dysmenorrhoea. There is also history of progressively increasing right lower abdominal pain as well as discomfort which was cyclically associated with the onset of menses. Transabdominal sonography showed-Endometrial splitting into two at the fundussuggesting bicornuate uterus. Echogenic soft tissue in the cervical canal due to blood clots. Non visualized right kidney. Mildly enlarged left kidney. HSG done outside AHD suggestive of unicornuate uterus with single fallopian tube. IVU showed non visualized right kidney. Normally excreting left kidney. TVS showed normal sized septated nulliparus uterus with homogeneous myometrium and thick endometrium with proliferative phase echo. Mildly enlarged right ovary with mildly distended right tube. Mild collection adjacent to the vagina. Then the patient came to the gynaecology dept of AHD from where she was sent to our Radiology department to undergo MRI of pelvis. The MRI showed uterine didelphys. Obstructed hemivagina (right) with hematocolpos extended upto pelvic brim along right and posterior aspect of uterus through anomalous dilated remnant of right lower ureter with ipsilateral renal agenesis. Patient was diagnosed as OHVIRA syndrome radiologically. DOI: http://dx.doi.org/10.3329/pulse.v6i1-2.20358 Pulse Vol.6 January-December 2013 p.66-69
A Case of Recurrent Stroke in Left MCA Stenosis
Authors: Bhuiyan AA , Shahriar SMH , Nahid F , Alam MJ
Published: September 2014

We report the clinical, neuro-radiological findings of a young man who was admitted to Apollo Hospitals Dhaka, Bangladesh because of abrupt onset of aphasia and right sided mild hemiparesis. He had two strokes six days apart one and half years ago. His past medical history was significant for HTN, smoking. His MRI of the Brain showed acute infarct in left middle cerebral artery (MCA) region congruent with his symptoms and signs. MRA done during his first stroke showed left MCA long segment luminal narrowing. DSA done during initial stroke showed complete occlusion of superior division of left MCA with collateral flow from left anterior cerebral artery (ACA) and posterior cerebral artery (PCA) to left MCA. Other extensive work up for stroke etiology was inconclusive. His stroke recurrence points towards left MCA stenosis (which is reversible) with good collateral circulation which helped the patient get significant neurological recovery. In young patients with recurrent strokes with or without conventional risk factors, vascular anomalies (intra-cranial and extra-cranial) should be investigated to find out the other rare causes for strokes. As TEE was not done here, it conclusively can not be ascertained that some cardio-embolic source of stroke was not present. DOI: http://dx.doi.org/10.3329/pulse.v6i1-2.20359 Pulse Vol.6 January-December 2013 p.70-74
Reforming Technologies to Improve the Performance of Combustion Systems
Authors: Hassan Hashim , Khandelwal Bhupendra
Published: September 2014

A large number of theoretical and experimental studies have shown that the performance of kerosene combustion increases significantly if combustion is being assisted by the addition of hydrogen to the fuel/air mixture during the combustion process. It reduces the amount of CO, CO2 and NOx emissions, while increasing the flame stability limits. It also helps in bruning fuel/air mixtures at much leaner equivalence ratios. The same principle could be applied to gain benefits in gas turbine combustors. Hydrogen for this purpose could be produced by the reforming of hydrocarbon fuels using a reformer module. This paper presents key hydrogen reforming technologies which, by implementation in gas turbine combustors, hold potential for improving both their performance and service life.
Maize Response to Fertilizer Dosing at Three Sites in the Central Rift Valley of Ethiopia
Authors: Sime Getachew , Aune Jens
Published: September 2014

This study examines the agronomic response, efficiency and profitability of fertilizer microdosing in maize. An experiment with the following treatments was conducted: control without fertilizer, microdosing treatments, with the rate of 27 + 27, 53 + 53 and 80 + 80 kg ha−1, and banding of fertilizer with 100 + 100 kg ha−1 of di ammonium phosphate (DAP) + urea, applied at planting and jointing, respectively. The treatments were arranged in a randomized complete block design with four replications. The experiment was conducted during the 2011/2012 and 2012/2013 cropping seasons at Ziway, Melkassa and Hawassa in the semiarid central rift valley region of Ethiopia. Compared to the control, the fertilizer treatments had higher yield and fertilizer use efficiency (FUE) profitably. The 27 + 27 kg ha−1 fertilizer rate increased the grain yield by 19, 45 and 46% at Hawassa, Ziway and Melkassa, respectively, and it was equivalent to the higher rates. The value cost ratio (VCR) was highest with the lowest fertilizer rate, varying between seven and 11 in the treatment with 27 + 27 kg ha−1, but two and three in the banding treatment. Similarly, FUE was highest with the lowest fertilizer rate, varying between 23 and 34 kg kg−1 but 7 and 8 kg kg−1 in the banding treatment. The improved yield, FUE, VCR and gross margin in maize with microdosing at the 27 + 27 kg ha−1 of DAP + urea rate makes it low cost, low risk, high yielding and profitable. Therefore, application of this particular rate in maize may be an option for the marginal farmers in the region with similar socioeconomic and agroecological conditions.
The Cambridge Experiment
Authors: Iuliano Marco , Penz François
Published: September 2014

Since the latter part of 19th century photography has played a central role in the development of architecture for its persuasive visual impact. But, despite this clear interaction, there is still reluctance from scholars in accepting less rigid approaches to the two disciplines. Indeed, the combination of the subjects, with the necessary rigour, can open up new and effective horizons for architectural history, with a potential influence on the perceived reality: this could gradually establish attention towards less known heritage. In the case we present here, by means of a provocative exhibition on Cambridge’s buildings after the Second World War, we have used photography to re-evaluate modern architecture. Cambridge in Concrete. Images from the RIBA British Architectural Library Photographs Collection, was held on the occasion of the University of Cambridge Department of Architecture’s Centenary (1912-2012). The cues for our task were contained in the collections of the Royal Institute of British Architects: the photographic archive is the world’s biggest holding of architectural images which, since 2012, has been renamed in honour of Robert Elwall (1953-2012), first curator of the collection. As part of the exhibition we published a limited edition catalogue; we have here revisited, combined and enlarged our original essays.
Elevated Circulating TNF-α in Fat-Free Mass Non-Responders Compared to Responders Following Exercise Training in Older Women
Authors: Fisher Gordon , Bickel C. , Hunter Gary
Published: September 2014

The purpose of this investigation was to determine if differences in inflammatory cytokines exist between fat-free mass responders versus non-responders following a combined resistance/aerobic training program in older women. Fifty women over 60 years old, mean BMI 27 ± 4 (kg/m2) and physically untrained, participated in a combined training program for 16-weeks. Body composition, muscle strength, and serum inflammatory markers (TNF-α, CRP, and IL-6) were assessed at baseline and 16-weeks post-training. A significant time effect was observed for weight, %fat, fat mass, and all strength measures (p < 0.05). A group interaction was observed for TNF-α (p < 0.05), which revealed higher concentrations of circulating TNF-α at baseline (18%) and post-exercise training (24%) in non-responders compared to responders (p < 0.05). In conclusion, this study revealed a significantly greater concentration of circulating TNF-α in older women that do not increase fat-free mass following training.
Dnmt3b Prefers Germ Line Genes and Centromeric Regions: Lessons from the ICF Syndrome and Cancer and Implications for Diseases
Authors: Walton Emma , Francastel Claire , Velasco Guillaume
Published: September 2014

The correct establishment and maintenance of DNA methylation patterns are critical for mammalian development and the control of normal cell growth and differentiation. DNA methylation has profound effects on the mammalian genome, including transcriptional repression, modulation of chromatin structure, X chromosome inactivation, genomic imprinting, and the suppression of the detrimental effects of repetitive and parasitic DNA sequences on genome integrity. Consistent with its essential role in normal cells and predominance at repetitive genomic regions, aberrant changes of DNA methylation patterns are a common feature of diseases with chromosomal and genomic instabilities. In this context, the functions of DNA methyltransferases (DNMTs) can be affected by mutations or alterations of their expression. DNMT3B, which is involved in de novo methylation, is of particular interest not only because of its important role in development, but also because of its dysfunction in human diseases. Expression of catalytically inactive isoforms has been associated with cancer risk and germ line hypomorphic mutations with the ICF syndrome (Immunodeficiency Centromeric instability Facial anomalies). In these diseases, global genomic hypomethylation affects repeated sequences around centromeric regions, which make up large blocks of heterochromatin, and is associated with chromosome instability, impaired chromosome segregation and perturbed nuclear architecture. The review will focus on recent data about the function of DNMT3B, and the consequences of its deregulated activity on pathological DNA hypomethylation, including the illicit activation of germ line-specific genes and accumulation of transcripts originating from repeated satellite sequences, which may represent novel physiopathological biomarkers for human diseases. Notably, we focus on cancer and the ICF syndrome, pathological contexts in which hypomethylation has been extensively characterized. We also discuss the potential contribution of these deregulated protein-coding and non-coding transcription programs to the perturbation of cellular phenotypes.
Hexaethylguanidinium Salts
Authors: Salchner Robert , Kahlenberg Volker , Gelbrich Thomas , Wurst Klaus , Rauch Martin , Laus Gerhard , Schottenberger Herwig
Published: September 2014

Crystal structures of five hexaethylguanidinium salts (PF6− 1, FeCl4− 2, CuCl42−·H2O 3, CoBr42−/Br−·H2O 4, bistriflimide 5) were determined. Short interionic contacts were identified. Cyclic voltammetry of 2 revealed an electrochemical window from +1.0 to −1.5 V with a single Fe(III)/Fe(II) redox event at −0.27 V on a gold electrode versus Ag/AgCl.
Optimization Models and Methods for Demand-Side Management of Residential Users: A Survey
Authors: Barbato Antimo , Capone Antonio
Published: September 2014

The residential sector is currently one of the major contributors to the global energy balance. However, the energy demand of residential users has been so far largely uncontrollable and inelastic with respect to the power grid conditions. With the massive introduction of renewable energy sources and the large variations in energy flows, also the residential sector is required to provide some flexibility in energy use so as to contribute to the stability and efficiency of the electric system. To address this issue, demand management mechanisms can be used to optimally manage the energy resources of customers and their energy demand profiles. A very promising technique is represented by demand-side management (DSM), which consists in a proactive method aimed at making users energy-efficient in the long term. In this paper, we survey the most relevant studies on optimization methods for DSM of residential consumers. Specifically, we review the related literature according to three axes defining contrasting characteristics of the schemes proposed: DSM for individual users versus DSM for cooperative consumers, deterministic DSM versus stochastic DSM and day-ahead DSM versus real-time DSM. Based on this classification, we provide a big picture of the key features of different approaches and techniques and discuss future research directions.
7R Data Value Framework for Open Data in Practice: Fusepool
Authors: Kaschesky Michael , Selmi Luigi
Published: September 2014

Based on existing literature, this article makes a case for open (government) data as supporting political efficiency, socio-economic innovation and administrative efficiency, but also finds a lack of measurable impact. It attributes the lack of impact to shortcomings regarding data access (must be efficient) and data usefulness (must be effective). To address these shortcomings, seven key activities that add value to data are identified and are combined into the 7R Data Value Framework, which is an applied methodology for linked data to systematically address both technical and social shortcomings. The 7R Data Value Framework is then applied to the international Fusepool project that develops a set of integrated software components to ease the publishing of open data based on linked data and associated best practices. Real-life applications for the Dutch Parliament and the Libraries of Free University of Berlin are presented, followed by a concluding discussion.
Sustaining Behavior Changes Following a Venous Leg Ulcer Client Education Program
Authors: Miller Charne , Kapp Suzanne , Donohue Lisa
Published: September 2014

Venous leg ulcers are a symptom of chronic insufficiency of the veins. This study considered the sustainability of behavior changes arising from a client focus e-Learning education program called the “Leg Ulcer Prevention Program” (LUPP) for people with a venous leg ulcer. Data from two related studies were used to enable a single sample (n = 49) examination of behavior maintenance across an average 8 to 9 months period. Physical activity levels increased over time. Leg elevation, calf muscle exercises, and soap substitute use were seen to fluctuate over the follow up time points. The use of a moisturizer showed gradual decline over time. The provision of a client-focused venous leg ulcer program was associated with behavior changes that had varied sustainability across the evaluation period.
Perforating Granuloma Annulare — An Unusual Subtype of a Common Disease
Authors: Alves João , Barreiros Hugo , Bártolo Elvira
Published: September 2014

Perforating granuloma annulare (GA) is a rare subset of GA with an unknown etiology and chronic course. Herein, we report the case of 72 year-old women with a 3-month history of a post-traumatic, persistent, erythematous and exudative plaque located on her left leg. Differential diagnosis included mycobacterial infection, subcutaneous mycosis, perforating dermatoses, pyoderma and squamous cell carcinoma. The histopathology was highly suggestive of a perforating GA. The patient was treated with betamethasone dipropionate cream applied once daily and a complete resolution of the lesion was observed in three weeks. Despite being a very rare subtype of a common disease, perforating granuloma annulare has clinical and histopathological characteristic features that facilitate the differential diagnosis, avoiding unnecessary procedures and inadequate and potentially more invasive treatments.
A Synthetic Method for Atmospheric Diffusion Simulation and Environmental Impact Assessment of Accidental Pollution in the Chemical Industry in a WEBGIS Context
Authors: Ni Haochen , Rui Yikang , Wang Jiechen , Cheng Liang
Published: September 2014

The chemical industry poses a potential security risk to factory personnel and neighboring residents. In order to mitigate prospective damage, a synthetic method must be developed for an emergency response. With the development of environmental numeric simulation models, model integration methods, and modern information technology, many Decision Support Systems (DSSs) have been established. However, existing systems still have limitations, in terms of synthetic simulation and network interoperation. In order to resolve these limitations, the matured simulation model for chemical accidents was integrated into the WEB Geographic Information System (WEBGIS) platform. The complete workflow of the emergency response, including raw data (meteorology information, and accident information) management, numeric simulation of different kinds of accidents, environmental impact assessments, and representation of the simulation results were achieved. This allowed comprehensive and real-time simulation of acute accidents in the chemical industry. The main contribution of this paper is that an organizational mechanism of the model set, based on the accident type and pollutant substance; a scheduling mechanism for the parallel processing of multi-accident-type, multi-accident-substance, and multi-simulation-model; and finally a presentation method for scalar and vector data on the web browser on the integration of a WEB Geographic Information System (WEBGIS) platform. The outcomes demonstrated that this method could provide effective support for deciding emergency responses of acute chemical accidents.
Rumphellols A and B, New Caryophyllene Sesquiterpenoids from a Formosan Gorgonian Coral, Rumphella antipathies
Authors: Chung Hsu-Ming , Wang Wei-Hsien , Hwang Tsong-Long , Chen Jih-Jung , Fang Lee-Shing , Wen Zhi-Hong , Wang Yu-Bao , Wu Yang-Chang , Sung Ping-Jyun
Published: September 2014

Two new marine-derived caryophyllene-type sesquiterpenoids, rumphellols A and B (1 and 2), were obtained from the gorgonian coral, Rumphella antipathies, collected off the waters of Taiwan. Although caryophyllene-type sesquiterpenes are rarely found in marine organisms, compounds of this type could be principal components of R. antipathies. The structures of new Compounds 1 and 2 were determined by analysis of their spectroscopic data, including 1D and 2D NMR experiments. Caryophyllene 1 and 2 were evaluated in terms of their anti-inflammatory activity by examining their inhibitory effects on the generation of superoxide anions and the release of elastase by human neutrophils.
EPAS-1 Mediates SP-1-Dependent FBI-1 Expression and Regulates Tumor Cell Survival and Proliferation
Authors: Wang Xiaogang , Cao Peng , Li Zhiqing , Wu Dongyang , Wang Xi , Liang Guobiao
Published: September 2014

Factor binding IST-1 (FBI-1) plays an important role in oncogenic transformation and tumorigenesis. As FBI-1 is over-expressed in multiple human cancers, the regulation of itself would provide new effective options for cancer intervention. In this work, we aimed to study the role that EPAS-1 plays in regulating FBI-1. We use the fact that specificity protein-1 (SP-1) is one of the crucial transcription factors of FBI-1, and that SP-1 can interact with the endothelial pas domain protein-1 (EPAS-1) for the induction of hypoxia related genes. The study showed that EPAS-1 plays an indispensible role in SP-1 transcription factor-mediated FBI-1 induction, and participated in tumor cell survival and proliferation. Thus, EPAS-1 could be a novel target for cancer therapeutics.
How Using Dedicated Software Can Improve RECIST Readings
Authors: René Amandine , Aufort Sophie , Mohamed Salim , Daures Jean , Chemouny Stéphane , Bonnel Christophe , Gallix Benoit
Published: September 2014

Decision support tools exist for oncologic follow up. Their main interest is to help physicians improve their oncologic readings but this theoretical benefit has to be quantified by concrete evidence. The purpose of the study was to evaluate and quantify the impact of using dedicated software on RECIST readings. A comparison was made between RECIST readings without dedicated application vs. readings using dedicated software (Myrian® XL-Onco, Intrasense, France) with specific functionalities such as 3D elastic target matching and automated calculation of tumoral response. A retrospective database of 40 patients who underwent a CT scan follow up was used (thoracic/abdominal lesions). The reading panel was composed of two radiologists. Reading times, intra/inter-operator reproducibility of measurements and RECIST response misclassifications were evaluated. On average, reading time was reduced by 49.7% using dedicated software. A more important saving was observed for lung lesions evaluations (63.4% vs. 36.1% for hepatic targets). Inter and intra-operator reproducibility of measurements was excellent for both reading methods. Using dedicated software prevented misclassifications on 10 readings out of 120 (eight due to calculation errors). The use of dedicated oncology software optimises RECIST evaluation by decreasing reading times significantly and avoiding response misclassifications due to manual calculation errors or approximations.
Fetal Cell Based Prenatal Diagnosis: Perspectives on the Present and Future
Authors: Fiddler Morris
Published: September 2014

The ability to capture and analyze fetal cells from maternal circulation or other sources during pregnancy has been a goal of prenatal diagnostics for over thirty years. The vision of replacing invasive prenatal diagnostic procedures with the prospect of having the entire fetal genome in hand non-invasively for chromosomal and molecular studies for both clinical and research use has brought many investigators and innovations into the effort. While the object of this desire, however, has remained elusive, the aspiration for this approach to non-invasive prenatal diagnosis remains and the inquiry has continued. With the advent of screening by cell-free DNA analysis, the standards for fetal cell based prenatal diagnostics have been sharpened. Relevant aspects of the history and the current status of investigations to meet the goal of having an accessible and reliable strategy for capturing and analyzing fetal cells during pregnancy are reviewed.
Upgrade Recycling of Cast Iron Scrap Chips towards β-FeSi2 Thermoelectric Materials
Authors: Laila Assayidatul , Nanko Makoto , Takeda Masatoshi
Published: September 2014

The upgrade recycling of cast-iron scrap chips towards β-FeSi2 thermoelectric materials is proposed as an eco-friendly and cost-effective production process. By using scrap waste from the machining process of cast-iron components, the material cost to fabricate β-FeSi2 is reduced and the industrial waste is recycled. In this study, β-FeSi2 specimens obtained from cast iron scrap chips were prepared both in the undoped form and doped with Al and Co elements. The maximum figure of merit (ZT) indicated a thermoelectric performance of approximately 70% in p-type samples and nearly 90% in n-type samples compared to β-FeSi2 prepared from pure Fe and other published studies. The use of cast iron scrap chips to produce β-FeSi2 shows promise as an eco-friendly and cost-effective production process for thermoelectric materials.
Ferroelectric Switching of Vinylidene and Trifluoroethylene Copolymer Thin Films on Au Electrodes Modified with Self-Assembled Monolayers
Authors: Tsutsumi Naoto , Kitano Tomotaka , Kinashi Kenji , Sakai Wataru
Published: September 2014

The ferroelectric switching characteristics of a vinylidene fluoride and trifluoroethylene copolymer were significantly changed via the chemical modification of a gold electrode with an alkanethiol self-assembled monolayer (SAM). The alkanethiol SAM-Au electrode successfully suppressed the leakage current (dark current) from the electrode to the bulk ferroelectric. Smaller leakage currents led to the formation of an effective electric field in the bulk ferroelectric. At switching cycles ranging from 10 to 100 kHz, significant changes in the ferroelectric properties were observed. At 100 kHz, a remanent polarization (Pr) of 68 mC·m−2 was measured, whereas a very small Pr value of 2.4 mC·m−2 was measured for the sample without a SAM. The switching speed of the SAM-Au electrode is as twice as fast as that of the unmodified electrode. A large potential barrier was formed via the insertion of a SAM between the Au electrode and the ferroelectric, effectively changing the ferroelectric switching characteristics.
Obtaining Spheroplasts of Armored Dinoflagellates and First Single-Channel Recordings of Their Ion Channels Using Patch-Clamping
Authors: Pozdnyakov Ilya , Matantseva Olga , Negulyaev Yuri , Skarlato Sergei
Published: September 2014

Ion channels are tightly involved in various aspects of cell physiology, including cell signaling, proliferation, motility, endo- and exo-cytosis. They may be involved in toxin production and release by marine dinoflagellates, as well as harmful algal bloom proliferation. So far, the patch-clamp technique, which is the most powerful method to study the activity of ion channels, has not been applied to dinoflagellate cells, due to their complex cellulose-containing cell coverings. In this paper, we describe a new approach to overcome this problem, based on the preparation of spheroplasts from armored bloom-forming dinoflagellate Prorocentrum minimum. We treated the cells of P. minimum with a cellulose synthesis inhibitor, 2,6-dichlorobenzonitrile (DCB), and found out that it could also induce ecdysis and arrest cell shape maintenance in these microalgae. Treatment with 100–250 µM DCB led to an acceptable 10% yield of P. minimum spheroplasts and was independent of the incubation time in the range of 1–5 days. We show that such spheroplasts are suitable for patch-clamping in the cell-attached mode and can form 1–10 GOhm patch contact with a glass micropipette, allowing recording of ion channel activity. The first single-channel recordings of dinoflagellate ion channels are presented.
Synthesis and Structure of Sulfur Derivatives from 2-Aminobenzimidazole
Authors: Cruz Alejandro , Padilla-Martínez Itzia , García-Báez Efrén , Guerrero-Muñoz Gerardo
Published: September 2014

The reactions of the benzimidazole nitrogen atoms and the exocyclic amino group of 2-aminobenzimidazole with CS2 in NaOH basic medium followed by methylation with methyl iodide was explored. With careful control of the stoichiometric quantities and addition sequences, this set of reactions allows the selective functionalization of the benzimidazole ring with N-dithiocarbamate, S-methyldithiocarbamate or dimethyl- dithiocarboimidate groups. The products were characterized by 1H-, 13C-NMR spectroscopy and three of them by X-ray diffraction analysis. The preferred isomers, tautomers and conformers were established.
Second Order Kinetic Modeling of Headspace Solid Phase Microextraction of Flavors Released from Selected Food Model Systems
Authors: Zhang Jiyuan , Cheong Mun-Wai , Yu Bin , Curran Philip , Zhou Weibiao
Published: September 2014

The application of headspace-solid phase microextraction (HS-SPME) has been widely used in various fields as a simple and versatile method, yet challenging in quantification. In order to improve the reproducibility in quantification, a mathematical model with its root in psychological modeling and chemical reactor modeling was developed, describing the kinetic behavior of aroma active compounds extracted by SPME from two different food model systems, i.e., a semi-solid food and a liquid food. The model accounted for both adsorption and release of the analytes from SPME fiber, which occurred simultaneously but were counter-directed. The model had four parameters and their estimated values were found to be more reproducible than the direct measurement of the compounds themselves by instrumental analysis. With the relative standard deviations (RSD) of each parameter less than 5% and root mean square error (RMSE) less than 0.15, the model was proved to be a robust one in estimating the release of a wide range of low molecular weight acetates at three environmental temperatures i.e., 30, 40 and 60 °C. More insights of SPME behavior regarding the small molecule analytes were also obtained through the kinetic parameters and the model itself.
Hydrogel Polysaccharides of Tamarind and Xanthan to Formulate Hydrodynamically Balanced Matrix Tablets of Famotidine
Authors: Razavi Mahboubeh , Nyamathulla Shaik , Karimian Hamed , Moghadamtousi Soheil , Noordin Mohamed
Published: September 2014

The gastroretentive dosage form of famotidine was modified using tamarind seed powders to prolong the gastric retention time. Tamarind seeds were used in two different forms having different swelling and gelling properties: with husk (TSP) or without husk (TKP). TKP (TKP1 to TKP 6) and TSP (TSP1 to TSP 6) series were prepared using tamarind powder:xanthan in the ratios of 5:0, 4:1, 3:2, 2:3, 1:4, 0:5, respectively. The matrix tablets were prepared by the wet granulation method and evaluated for pharmacopoeial requirements. TKP2 was the optimum formulation as it had a short floating lag time (FLT < 30 s) and more than 98.5% drug release in 12 h. The dissolution data were fitted to popular mathematical models to assess the mechanism of drug release, and the optimum formulation showed a predominant first order release and diffusion mechanism. It was concluded that the TKP2 prepared using tamarind kernel powder:xanthan (4:1) was the optimum formulation with shortest floating lag time and more than 90% release in the determined period of time.
Synthesis with Perfect Atom Economy: Generation of Furan Derivatives by 1,3-Dipolar Cycloaddition of Acetylenedicarboxylates at Cyclooctynes
Authors: Banert Klaus , Bochmann Sandra , Ihle Andreas , Plefka Oliver , Taubert Florian , Walther Tina , Korb Marcus , Rüffer Tobias , Lang Heinrich
Published: September 2014

Cyclooctyne and cycloocten-5-yne undergo, at room temperature, a 1,3-dipolar cycloaddition with dialkyl acetylenedicarboxylates 1a,b to generate furan-derived short-lived intermediates 2, which can be trapped by two additional equivalents of 1a,b or alternatively by methanol, phenol, water or aldehydes to yield polycyclic products 3b–d, orthoesters 4a–c, ketones 5 or epoxides 6a,b, respectively. Treatment of bis(trimethylsilyl) acetylenedicarboxylate (1c) with cyclooctyne leads to the ketone 7 via retro-Brook rearrangement of the dipolar intermediate 2c. In all cases, the products are formed with perfect atom economy.
Self-Assembly in Biosilicification and Biotemplated Silica Materials
Authors: Fernandes Francisco , Coradin Thibaud , Aimé Carole
Published: September 2014

During evolution, living organisms have learned to design biomolecules exhibiting self-assembly properties to build-up materials with complex organizations. This is particularly evidenced by the delicate siliceous structures of diatoms and sponges. These structures have been considered as inspiration sources for the preparation of nanoscale and nanostructured silica-based materials templated by the self-assembled natural or biomimetic molecules. These templates range from short peptides to large viruses, leading to biohybrid objects with a wide variety of dimensions, shapes and organization. A more recent strategy based on the integration of biological self-assembly as the driving force of silica nanoparticles organization offers new perspectives to elaborate highly-tunable, biofunctional nanocomposites.
Assessing the Average Sodium Content of Prepacked Foods with Nutrition Declarations: The Importance of Sales Data
Authors: Korošec Živa , Pravst Igor
Published: September 2014

Processed foods are recognized as a major contributor to high dietary sodium intake, associated with increased risk of cardiovascular disease. Different public health actions are being introduced to reduce sodium content in processed foods and sodium intake in general. A gradual reduction of sodium content in processed foods was proposed in Slovenia, but monitoring sodium content in the food supply is essential to evaluate the progress. Our primary objective was to test a new approach for assessing the sales-weighted average sodium content of prepacked foods on the market. We show that a combination of 12-month food sales data provided by food retailers covering the majority of the national market and a comprehensive food composition database compiled using food labelling data represent a robust and cost-effective approach to assessing the sales-weighted average sodium content of prepacked foods. Food categories with the highest sodium content were processed meats (particularly dry cured meat), ready meals (especially frozen pizza) and cheese. The reported results show that in most investigated food categories, market leaders in the Slovenian market have lower sodium contents than the category average. The proposed method represents an excellent tool for monitoring sodium content in the food supply.
Is the Inclusion of Animal Source Foods in Fortified Blended Foods Justified?
Authors: Noriega Kristen , Lindshield Brian
Published: September 2014

Fortified blended foods (FBF) are used for the prevention and treatment of moderate acute malnutrition (MAM) in nutritionally vulnerable individuals, particularly children. A recent review of FBF recommended the addition of animal source food (ASF) in the form of whey protein concentrate (WPC), especially to corn-soy blends. The justification for this recommendation includes the potential of ASF to increase length, weight, muscle mass accretion and recovery from wasting, as well as to improve protein quality and provide essential growth factors. Evidence was collected from the following four different types of studies: (1) epidemiological; (2) ASF versus no intervention or a low-calorie control; (3) ASF versus an isocaloric non-ASF; and (4) ASF versus an isocaloric, isonitrogenous non-ASF. Epidemiological studies consistently associated improved growth outcomes with ASF consumption; however, little evidence from isocaloric and isocaloric, isonitrogenous interventions was found to support the inclusion of meat or milk in FBF. Evidence suggests that whey may benefit muscle mass accretion, but not linear growth. Overall, little evidence supports the costly addition of WPC to FBFs. Further, randomized isocaloric, isonitrogenous ASF interventions with nutritionally vulnerable children are needed.
Antibiotic Resistance Related to Biofilm Formation in Klebsiella pneumoniae
Authors: Vuotto Claudia , Longo Francesca , Balice Maria , Donelli Gianfranco , Varaldo Pietro
Published: September 2014

The Gram-negative opportunistic pathogen, Klebsiella pneumoniae, is responsible for causing a spectrum of community-acquired and nosocomial infections and typically infects patients with indwelling medical devices, especially urinary catheters, on which this microorganism is able to grow as a biofilm. The increasingly frequent acquisition of antibiotic resistance by K. pneumoniae strains has given rise to a global spread of this multidrug-resistant pathogen, mostly at the hospital level. This scenario is exacerbated when it is noted that intrinsic resistance to antimicrobial agents dramatically increases when K. pneumoniae strains grow as a biofilm. This review will summarize the findings about the antibiotic resistance related to biofilm formation in K. pneumoniae.
A Multichannel Gray Level Co-Occurrence Matrix for Multi/Hyperspectral Image Texture Representation
Authors: Huang Xin , Liu Xiaobo , Zhang Liangpei
Published: September 2014

This study proposes a novel method for multichannel image gray level co-occurrence matrix (GLCM) texture representation. It is well known that the standard procedure for the automatic extraction of GLCM textures is based on a mono-spectral image. In real applications, however, the GLCM texture feature extraction always refers to multi/hyperspectral images. The widely used strategy to deal with this issue is to calculate the GLCM from the first principal component or the panchromatic band, which do not include all the useful information. Accordingly, in this study, we propose to represent the multichannel textures for multi/hyperspectral imagery by the use of: (1) clustering algorithms; and (2) sparse representation, respectively. In this way, the multi/hyperspectral images can be described using a series of quantized codes or dictionaries, which are more suitable for multichannel texture representation than the traditional methods. Specifically, K-means and fuzzy c-means methods are adopted to generate the codes of an image from the clustering point of view, while a sparse dictionary learning method based on two coding rules is proposed to produce the texture primitives. The proposed multichannel GLCM textural extraction methods were evaluated with four multi/hyperspectral datasets: GeoEye-1 and QuickBird multispectral images of the city of Wuhan, the well-known AVIRIS hyperspectral dataset from the Indian Pines test site, and the HYDICE airborne hyperspectral dataset from the Washington DC Mall. The results show that both the clustering-based and sparsity-based GLCM textures outperform the traditional method (extraction based on the first principal component) in terms of classification accuracies in all the experiments.
Assessment of Eye Fatigue Caused by 3D Displays Based on Multimodal Measurements
Authors: Bang Jae , Heo Hwan , Choi Jong-Suk , Park Kang
Published: September 2014

With the development of 3D displays, user’s eye fatigue has been an important issue when viewing these displays. There have been previous studies conducted on eye fatigue related to 3D display use, however, most of these have employed a limited number of modalities for measurements, such as electroencephalograms (EEGs), biomedical signals, and eye responses. In this paper, we propose a new assessment of eye fatigue related to 3D display use based on multimodal measurements. compared to previous works Our research is novel in the following four ways: first, to enhance the accuracy of assessment of eye fatigue, we measure EEG signals, eye blinking rate (BR), facial temperature (FT), and a subjective evaluation (SE) score before and after a user watches a 3D display; second, in order to accurately measure BR in a manner that is convenient for the user, we implement a remote gaze-tracking system using a high speed (mega-pixel) camera that measures eye blinks of both eyes; thirdly, changes in the FT are measured using a remote thermal camera, which can enhance the measurement of eye fatigue, and fourth, we perform various statistical analyses to evaluate the correlation between the EEG signal, eye BR, FT, and the SE score based on the T-test, correlation matrix, and effect size. Results show that the correlation of the SE with other data (FT, BR, and EEG) is the highest, while those of the FT, BR, and EEG with other data are second, third, and fourth highest, respectively.
Towards an Electronic Dog Nose: Surface Plasmon Resonance Immunosensor for Security and Safety
Authors: Onodera Takeshi , Toko Kiyoshi
Published: September 2014

This review describes an “electronic dog nose” based on a surface plasmon resonance (SPR) sensor and an antigen–antibody interaction for security and safety. We have concentrated on developing appropriate sensor surfaces for the SPR sensor for practical use. The review covers different surface fabrications, which all include variations of a self-assembled monolayer containing oligo(ethylene glycol), dendrimer, and hydrophilic polymer. We have carried out detection of explosives using the sensor surfaces. For the SPR sensor to detect explosives, the vapor or particles of the target substances have to be dissolved in a liquid. Therefore, we also review the development of sampling processes for explosives, and a protocol for the measurement of explosives on the SPR sensor in the field. Additionally, sensing elements, which have the potential to be applied for the electronic dog nose, are described.
An Adaptive Failure Detector Based on Quality of Service in Peer-to-Peer Networks
Authors: Dong Jian , Ren Xiao , Zuo Decheng , Liu Hongwei
Published: September 2014

The failure detector is one of the fundamental components that maintain high availability of Peer-to-Peer (P2P) networks. Under different network conditions, the adaptive failure detector based on quality of service (QoS) can achieve the detection time and accuracy required by upper applications with lower detection overhead. In P2P systems, complexity of network and high churn lead to high message loss rate. To reduce the impact on detection accuracy, baseline detection strategy based on retransmission mechanism has been employed widely in many P2P applications; however, Chen’s classic adaptive model cannot describe this kind of detection strategy. In order to provide an efficient service of failure detection in P2P systems, this paper establishes a novel QoS evaluation model for the baseline detection strategy. The relationship between the detection period and the QoS is discussed and on this basis, an adaptive failure detector (B-AFD) is proposed, which can meet the quantitative QoS metrics under changing network environment. Meanwhile, it is observed from the experimental analysis that B-AFD achieves better detection accuracy and time with lower detection overhead compared to the traditional baseline strategy and the adaptive detectors based on Chen’s model. Moreover, B-AFD has better adaptability to P2P network.
Sequential and Automatic Image-Sequence Registration of Road Areas Monitored from a Hovering Helicopter
Authors: Nejadasl Fatemeh , Lindenbergh Roderik
Published: September 2014

In this paper, we propose an automatic and sequential method for the registration of an image sequence of a road area without ignoring scene-induced motion. This method contributes to a larger work, aiming at vehicle tracking. A typical image sequence is recorded from a helicopter hovering above the freeway. The demand for automation is inevitable due to the large number of images and continuous changes in the traffic situation and weather conditions. A framework is designed and implemented for this purpose. The registration errors are removed in a sequential way based on two homography assumptions. First, an approximate registration is obtained, which is efficiently refined in a second step, using a restricted search area. The results of the stabilization framework are demonstrated on an image sequence consisting of 1500 images and show that our method allows a registration between arbitrary images in the sequence with a geometric error of zero in pixel accuracy.
Clostridium and Bacillus Binary Enterotoxins: Bad for the Bowels, and Eukaryotic Being
Authors: Stiles Bradley , Pradhan Kisha , Fleming Jodie , Samy Ramar , Barth Holger , Popoff Michel
Published: September 2014

Some pathogenic spore-forming bacilli employ a binary protein mechanism for intoxicating the intestinal tracts of insects, animals, and humans. These Gram-positive bacteria and their toxins include Clostridium botulinum (C2 toxin), Clostridium difficile (C. difficile toxin or CDT), Clostridium perfringens (ι-toxin and binary enterotoxin, or BEC), Clostridium spiroforme (C. spiroforme toxin or CST), as well as Bacillus cereus (vegetative insecticidal protein or VIP). These gut-acting proteins form an AB complex composed of ADP-ribosyl transferase (A) and cell-binding (B) components that intoxicate cells via receptor-mediated endocytosis and endosomal trafficking. Once inside the cytosol, the A components inhibit normal cell functions by mono-ADP-ribosylation of globular actin, which induces cytoskeletal disarray and death. Important aspects of each bacterium and binary enterotoxin will be highlighted in this review, with particular focus upon the disease process involving the biochemistry and modes of action for each toxin.
Investigation of Rainfall-Runoff Processes and Soil Moisture Dynamics in Grassland Plots under Simulated Rainfall Conditions
Authors: Zhao Nana , Yu Fuliang , Li Chuanzhe , Wang Hao , Liu Jia , Mu Wenbin
Published: September 2014

The characteristics of rainfall-runoff are important aspects of hydrological processes. In this study, rainfall-runoff processes and soil moisture dynamics at different soil depths and slope positions of grassland with two different row spacings (5 cm and 10 cm, respectively, referred to as R5 and R10) were analyzed, by means of a solution of rainfall simulation experiments. Bare land was also considered as a comparison. The results showed that the mechanism of runoff generation was mainly excess infiltration overland flow. The surface runoff amount of R5 plot was greater than that of R10, while the interflow amount of R10 was larger than that of R5 plot, although the differences of the subsurface runoff processes between plots R5 and R10 were little. The effects of rainfall intensity on the surface runoff were significant, but not obvious on the interflow and recession curve, which can be described as a simple exponential equation, with a fitting degree of up to 0.854–0.996. The response of soil moisture to rainfall and evapotranspiration was mainly in the 0–20 cm layer, and the response at the 40 cm layer to rainfall was slower and generally occurred after the rainfall stopped. The upper slope generally responded fastest to rainfall, and the foot of the slope was the slowest. The results presented here could provide insights into understanding the surface and subsurface runoff processes and soil moisture dynamics for grasslands in semi-arid regions.