bluuebunny/crossref_metadata_2025 huggingface dataset:
Respiratory Syncytial Virus Vaccines: A Review of the Candidates and the Approved Vaccines
Authors: Topalidou Xanthippi , Kalergis Alexis M. , Papazisis Georgios
Published: October 2023

Respiratory syncytial virus (RSV) is responsible for a significant proportion of global morbidity and mortality affecting young children and older adults. In the aftermath of formalin-inactivated RSV vaccine development, the effort to develop an immunizing agent was carefully guided by epidemiologic and pathophysiological evidence of the virus, including various vaccine technologies. The pipeline of RSV vaccine development includes messenger ribonucleic acid (mRNA), live-attenuated (LAV), subunit, and recombinant vector-based vaccine candidates targeting different virus proteins. The availability of vaccine candidates of various technologies enables adjustment to the individualized needs of each vulnerable age group. Arexvy® (GSK), followed by Abrysvo® (Pfizer), is the first vaccine available for market use as an immunizing agent to prevent lower respiratory tract disease in older adults. Abrysvo is additionally indicated for the passive immunization of infants by maternal administration during pregnancy. This review presents the RSV vaccine pipeline, analyzing the results of clinical trials. The key features of each vaccine technology are also mentioned. Currently, 24 vaccines are in the clinical stage of development, including the 2 licensed vaccines. Research in the field of RSV vaccination, including the pharmacovigilance methods of already approved vaccines, promotes the achievement of successful prevention.
Plasmodium Infection–Cure Cycles Increase the Capacity of Phagocytosis in Conventional Dendritic Cells
Authors: Adachi Ryosuke , Tamura Takahiko
Published: October 2023

Malaria stands as one of the most pervasive human infectious diseases globally and represents a prominent cause of mortality. Immunity against clinical malaria disease is achieved through multiple infection and treatment cycles, culminating in a substantial reduction in parasite burden. To investigate this phenomenon, we established a murine model involving repeated infection–cure cycles, whereby mice were infected with the lethal rodent malarial parasite Plasmodium berghei ANKA and subsequently treated with the anti-malarial drug pyrimethamine. Our earlier study revealed a significant decrease in the capacity of conventional dendritic cells (cDCs) to produce cytokines upon stimulation in infection-cured mice. In the present study, we aimed to further elucidate the modulation of cDC functionality during repeated infection–cure cycles by examining their phagocytic capacity. Administering fluorescent beads to mice resulted in no significant difference in the total number of bead-positive cells within the spleens of both uninfected and 3-cure (three cycles of infection–cure) mice. However, the proportion of the CD11c+F4/80− population within bead-positive cells was notably higher in 3-cure mice compared to uninfected mice. Subsequent in vitro analysis of bead phagocytosis by purified CD11c+cDCs revealed that the cDC2 subset from 3-cure mice exhibited significantly enhanced phagocytic capacity in comparison to their uninfected counterparts. These findings underscore the substantial impact of repeated infection–cure cycles on various facets of cDC function, potentially influencing the trajectory of immune responses against subsequent malaria infections.
Albocycline Is the Main Bioactive Antifungal Compound Produced by Streptomyces sp. OR6 against Verticillium dahliae
Authors: Calvo-Peña Carla , Cobos Rebeca , Sánchez-López José María , Ibañez Ana , Coque Juan José R.
Published: October 2023

Verticillium wilt is a soil-borne fungal disease that affects olive trees (Olea europaea) and poses a serious threat to their cultivation. The causal agent of this disease is Verticillium dahliae, a pathogen that is difficult to control with conventional methods. Therefore, there is a need to explore alternative strategies for the management of Verticillium wilt. In this study, we aimed to isolate and characterize actinobacteria from the rhizosphere of olive trees that could act as potential biocontrol agents against V. dahliae. We selected a Streptomyces sp. OR6 strain based on its in vitro antifungal activity and its ability to suppress the pathogen growth in soil samples. We identified the main active compound produced by this strain as albocycline, a macrolide polyketide with known antibacterial properties and some antifungal activity. Albocycline was able to efficiently suppress the germination of conidiospores. To our knowledge, this is the first report of albocycline as an effective agent against V. dahliae. Our results suggest that Streptomyces sp. OR6, or other albocycline-producing strains, could be used as a promising tool for the biological control of Verticillium wilt.
Construction of Multi-Level Ecological Security Pattern for World Natural Heritage Sites from the Perspective of Coupling and Coordination between Humans and Nature: A Case Study of Shilin Yi Autonomous County, China
Authors: Miao Xue , Leng Congbin , Dai Shiyu , Jin Jing , Peng Jiansong
Published: October 2023

Building ecological networks (ENs) is an important means to guarantee regional ecological security and achieve sustainable urban development. Development of ENs usually occurs at the county- or urban-area-scale, and there is a lack of linkage between ENs at different levels. Based on the systematic analysis of local environmental characteristics and ecological mechanisms of action in karst areas, the ENs at the county and urban areas levels are combined to build an ecological security pattern (ESP) for Shilin Yi Autonomous County (SYAC), a World Natural Heritage site. The results show that there are 18 Ecological resources in SYAC, with a total area of 326.512 km2 and 29 ecological corridors. In the northern part of the county, an absence of ecological resources and corridors occurred due to the fragmentation of landscape patches and poor ecological service functionality. In this study, three new ecological resources and seven corridors were added in the northern part of the county according to the patch area and landscape connectivity index (PALCI) to balance the layout of ecological resources and corridors in SYAC and improve regional habitat quality. In addition, a total of eight cultural and natural resources were identified in the urban areas of SYAC, and ten cultural and natural landscape corridors were identified. By overlaying the ENs of the county and the urban areas, we identified 3.977 km2 of Material Exchange Conversion Zone, 12.6593 km2 of Priority Restoration Zone, and ten Ecological Stepping Stones. This work helps to establish the interface between the upper and lower levels of the network, and correct for deficiencies of conflicting ecological processes at different levels, and integrate existing green-space system planning research about karst terrains.
Tenapanor Improves Long-Term Control of Hyperphosphatemia in Patients Receiving Maintenance Dialysis: the NORMALIZE Study
Authors: Silva Arnold L. , Chertow Glenn M. , Hernandez German T. , Lynn Robert I. , Tietjen David P. , Rosenbaum David P. , Yang Yang , Edelstein Susan
Published: October 2023

Key Points

Tenapanor is a first-in-class, minimally systemic sodium–hydrogen exchanger 3 inhibitor with a mechanism of action distinct from phosphate binders.

Tenapanor alone or with phosphate binders led to 35%–49% of patients achieving serum phosphate ≤4.5 mg/dl over an 18-month period versus 22% at baseline.

Tenapanor alone or with phosphate binders may help adults with CKD on maintenance dialysis achieve normal serum phosphate concentrations.

Background

Most patients with ESKD and hyperphosphatemia have difficulty controlling serum phosphate (sP) concentrations despite maintenance dialysis, dietary restriction, and phosphate binder treatment. NORMALIZE evaluated the efficacy and safety of tenapanor 30 mg twice daily alone or in combination with phosphate binders to achieve sP within the adult population reference range (2.5–4.5 mg/dl).

Methods

Patients who completed the Phase 3 PHREEDOM study could enroll in NORMALIZE. Patients enrolled in NORMALIZE who had received tenapanor during the PHREEDOM study (n=111) added sevelamer carbonate if sP was >4.5 mg/dl. Patients who had received sevelamer carbonate during the PHREEDOM study (n=61) added tenapanor and decreased sevelamer carbonate if sP was ≤4.5 mg/dl, per protocol titration schedule. Patients were followed in NORMALIZE for up to 18 months. We assessed efficacy in the full analysis set, defined as patients who received ≥1 dose of study drug and had ≥1 post-treatment sP measurement (n=171). We assessed safety in all patients who received ≥1 dose of study drug (n=172).

Results

At the end point visit, 57 of 171 patients (33%) in the full analysis set achieved sP between 2.5 and 4.5 mg/dl. Eight of 23 patients (35%) who were on tenapanor alone at the end point visit achieved sP between 2.5 and 4.5 mg/dl. The mean reduction from PHREEDOM baseline to end of NORMALIZE in sP was 2.0 mg/dl. Serum intact fibroblast growth factor-23 was significantly reduced; serum intact parathyroid hormone was significantly reduced among patients with intact parathyroid hormone ≥300 pg/ml at PHREEDOM baseline. The most commonly reported treatment-emergent adverse event was diarrhea in 38 of 172 patients (22%), which led to tenapanor discontinuation in four patients (2%).

Conclusions

Tenapanor alone or in combination with phosphate binders helped adult patients on maintenance dialysis achieve normal sP concentrations. Safety was consistent with previous studies of tenapanor.

Clinical trial registry name and registration number

A Long-Term Study to Evaluate the Ability of Tenapanor Alone or in Combination With Sevelamer to Treat to Goal Serum Phosphorus in Patients With ESKD on Dialysis (NORMALIZE), NCT03988920.
İsrail’e Dönüş Miti Bağlamında Kutsal Metnin Araçsallaştırılması
Authors: TOPRAK Bilal
Published: October 2023

Bu çalışma, Siyonizm ekseninde ve İsrail’in kuruluş miti bağlamında kutsal metnin araçsallaştırılmasını konu edinmektedir. Avrupa’da sömürgeci ve milliyetçi bir hareket olarak ortaya çıkan Siyonizm, politikalarını güçlendirmek için sıklıkla Yahudi kutsal metinlerini referans göstermiştir. Bu bağlamda ulus devletlerin vazgeçilmez bir parçası olarak kabul edilen vatan meselesini Filistin’e dönüş mitiyle, işgal ve yerleşim politikalarını ise Yeşu Kitabı’nın Siyonist yorumu üzerinden meşrulaştırmaya çalışmıştır. Bu yaklaşımların en görünür ve etkileyici hâlinin arkeolojinin kullanımı ve kutsal metinlerde geçen isimlerden hareketle haritalandırma çalışmaları üzerinden gerçekleştiğini söylemek mümkündür. Kuşkusuz bu aşamaların gerçekleşmesi için sürgünün itibarsızlaştırılması, İsrail toprağına ve dolayısıyla tarihe dönüş fikri büyük önem arz etmekteydi. Bu süreçlerin İsrail’in kurucu erkleri tarafından başarılı bir şekilde işletildiğini söylenebilir. Bu çalışmada Siyonist tarih anlayışı kurgulanırken, kutsal metnin hangi açılardan referans alındığı ve bunun arkeoloji ve haritalandırma üzerinden nasıl uygulandığı incelenmektedir. Ayrıca tüm bunların neticesinde ortaya çıkan mitik anlatı da eleştirel bir şekilde işlenmektedir.
CARACTERIZACIÓN Y ORIGEN GENÉTICO DE TRES RAZAS DE MAÍZ A PARTIR DE DATOS DE NUDOS CROMOSÓMICOS
Authors: Kato Yamakake Takeo Ángel
Published: October 2023

En la actualidad existe consenso general de que el maíz fue originado y domesticado a partir del teocintle anual mexicano. Los resultados citológicos han encontrado que el inicio de esta planta ocurrió en cinco centros de origen y domesticación en Mesoamérica. Muchos investigadores han estudiado la gran variación genética que el maíz muestra en varias regiones de México, pero ninguno ha propuesto el modo y lugar de origen de cada una de las razas de México. Se pensó que a través del análisis de patrones de distribución geográfica y racial de los nudos cromosómicos en datos obtenidos de un número mayor de accesiones y plantas por raza podría conocerse el origen y evolución de cada una de ellas. Se estudiaron 15 accesiones de la raza Chalqueño, 22 de Cónico y 19 de Cónico Norteño, tratando de analizar 20 plantas de cada accesión. Se compararon gráficamente grupos de nudos (cromosomas largos vs. cortos, brazos largos vs. cortos, etc.) buscando patrones de distribución que pudieran caracterizar y evidenciar el posible origen de cada una de las tres razas. De manera general, los resultados mostraron que Cónico Norteño se caracteriza porque posee una alta frecuencia de nudos grandes, superior que la de Cónico y Chalqueño, razas que comparten esas frecuencias con los nudos de tamaño medio, pero difieren en que Chalqueño tiene predominancia de nudos pequeños. La caracterización de las tres razas, junto con información previa sobre los complejos de nudos, permitió proponer el origen genético de cada una de ellas. Los resultados sugieren que los nudos cromosómicos son elementos importantes en la evolución de las razas del género Zea.
Review Essay: Sound Money without Free Banking: Revisiting Economic Principles
Authors: Hansen Kristoffer J. Mousten
Published: October 2023

Professor Lawrence H. White is one of the founders of the modern free banking school and a major scholar of monetary theory and history. In Better Money: Gold, Fiat, or Bitcoin? he draws on close to four decades of scholarship to answer the question put in the title: which monetary standard would be better. It should not come as a surprise that Professor White sees the contest mainly between gold and bitcoin.

What is a “better” money? Professor White proposes that this must be judged “nonpaternalistically” from the viewpoint of the money-holders themselves. This is surely the correct approach. Two criteria are laid down: a money must serve as a convenient and low-cost medium of exchange, which means non-declining and predictable purchasing power; and the monetary system as a whole should have desirable properties such as avoiding depressions associated with monetary disequilibrium (p. 17). While we find the approach and the first criterion eminently sensible, the second point is much more questionable. Much of the review is therefore devoted to aspects of this second point.
Practical training of the 5th-year students in clinical departments
Authors: Mytchenok O. , Kilmukhametova Yu. , Drozda I. , Soltys O. , Mytchenok M.
Published: October 2023

The educational process is a significant part of specialists' formation in medicine, including dentistry. Seekers of medical education in universities need the support and guidance of highly specialized teachers for their future realization as professionals. However, it is equally important for the students to be interested in successfully mastering the disciplines in different ways, from classroom work to independent projects. On the difficult student path of becoming a dentist, a teacher who can direct their ward in the right direction in the field of dental practice play a considerable role. Additionally, it is important to provide students with a high-quality theoretical base in university departments, modern clinical equipment for polishing professional practical skills, and constant support in the form of consultations, lectures, and master classes from leading specialists of the higher education institution. General medical disciplines are also a significant component of the educational program of dental students, as these subjects provide basic medical knowledge. Without mastering the materials of these disciplines, it will be difficult for the future dentist to integrate into the general field of medical practice. To fully understand and assimilate the material and topics during the lectures and classes, students need to be interested in learning more than what is prescribed in the curriculum of the educational program of the dental specialty; since this area of medicine is undergoing rapid development today. Therefore, such a type of activity as independent work is introduced in the student's curriculum. This type of work for students majorly contributes to improving discipline on the one hand and increases the ability of clinical thinking of future dentists on the other. The article is written in the form of a short scientific report.

Keywords: clinical practice, independent work, practical skills, education seeker, practical classes.
Konsep Keberkahan Pengasuhan Anak dalam Perspektif Islam
Authors: Aulia Alfia , Munafiah Nida'ul
Published: October 2023

Orangtua merupakan sekolah pertama bagi anak-anaknya, sudah kita ketahui bahwa orangtua mengasuh anaknya baik dari kecil sehingga dewasa, tujuan penelitian ini ialah memberikan pemahaman kepada orangtua bahwasannya di dalam pengasuhan anak terdapat keberkahan dari Allah Swt yang dilakukan orangtua apabila orangtua ikhlas dan sabar dalam mengasuhnya. bahkan Allah Swt akan memberikan ganjaran yang besar. Dalam mencapai keberkahan dalam pengasuhan anak Orangtua perlu mengetahui hal apa saja yang dapat dicapai ketika mengasuh anak, baik dalam segi pendidikan, adab dan akhlak, serta bersikap adil terhadap anak satu dengan anak lainnya. Untuk mengatasi tantangan ini orangtua perlu menjalani perannya dalam kehidupan sehari-hari, mengimbangi perkembangan anak serta membimbingnya agar mereka tumbuh menjadi anak yang sukses dan bahagia dunia serta Akhirat.
Implementing a College Service-Learning Model to Increase Music Appreciation and Narrative Skills of Students with Intellectual Disability
Authors: Chien Shan-Ken , Chou Yu-Chi
Published: October 2023

We developed and applied a Music and Narrative Curriculum for a college community service-learning course in a special education classroom of a local secondary school. The development of the curriculum stemmed from the music appreciation courses taught at a university. The curriculum consisted of three instructional phases, each with three core literacy. This article presents how to implement an eighteen-week general music education course, including classroom training and four intervention music lessons in a special education classroom at a university.
Victimological features of property crimes against property in current conditions
Authors: Bobrovnichiy I. N.
Published: October 2023

The article is devoted to the analysis of victimological features of crimes against property. Such crimes as theft, fraud, robbery, robbery are studied. Special attention is paid to victims of fraud committed remotely with the use of information and telecommunication technologies. The peculiarities of victims’ behavior became the basis of the research, since it is the behavior of a person that concentrates all the main factors forming his personality (social, demographic, biological, etc.). The behavior of a potential victim can be corrected to a greater extent. Therefore, the obtained data will undoubtedly help to develop and implement the most effective measures of victimological prevention and prevention of crimes against property.
Current issues of ensuring road safety and enforcement of administrative penalties for violation of road traffic rules in Russia
Authors: Gorshkov D. G. , Mayurov N. P. , Vysotsky S. A.
Published: October 2023

The article studies topical issues related to ensuring road safety in cases regulated by part 2 of article 12.8 of the Code of the Russian Federation on Administrative Offences (CAO RF). The author suggests possible ways to optimize the content of the legal norm in order to solve controversial issues in the modern Russian legislation on administrative offences and improve the quality of proceedings on cases of administrative offences. Actual legal problems of execution of punishments in cases of violations of traffic rules, in particular execution of administrative punishments in Russia have been studied.
Evaluation of Sport Facilities in Sport Cities in Jordan
Authors: Hamdan Sari
Published: October 2023

هدفت هذه الدراسة الى تقويم المنشآت الرياضة في المدن الرياضية في الأردن واستخدم الباحث المنهج الوصفي وقام ببناء أداة الدراسة بعد الرجوع الى المعايير الدولية والدراسات السابقة وتم اجراء معاملي الصدق والثبات لأداة الدراسة. بلغت عينة الدراسة (24) فرداً ممن يعملون في المدن الرياضية ( مدينة الحسين ، مدينة الحسن ، مدينة الأمير محمد، مدينة الأمير حمزة) واستنتجت الدراسة ان مستوى تقييم المدن الأربعة كان جيداً وكذلك هناك اختلاف في مستوى التقييم بين المدن الأربعة، وكانت مدينة الحسين هي الأفضل بالتقييم وأوصت الدراسة الى اعتماد أداة الدراسة لتقييم المنشآت الرياضية بشكل دوري ومن قبل خبراء من خارج نطاق العاملين في المدن الرياضية قيد الدراسة.
An Examination of the Concept of Pancasila based on Hadith and the Prophet's Political Commitment
Authors: Rahman Rahman , Srg Syahruddin , Sawaluddin Sawaluddin , Puyu Darsul S.
Published: October 2023

In recent years, many communities or social organizations have tried to replace Pancasila as the foundation of the State. Instead, they offer a State foundation with a religious label. The government responded quickly to the presence of these groups and even ended up disbanding and revoking their legal entity status. This paper seeks to provide an understanding of the relationship between Pancasila and Islam. This paper traces the normative and historical foundations of the concepts of the basic formulation of the State at the time of the Prophet. This paper uses a qualitative approach with data collection techniques through literature study. The results of this study indicate that there are at least two contexts that can prove that Pancasila has a relationship with Islam, namely: First, when the Prophet formulated the Medina Charter (Charter of Medina). Second, when the Prophet formulated the Hudaibiyah Agreement. The purpose of the formulation of the Medina Charter and the Hudaibiyah Agreement is the same as the purpose and formulation of Pancasila in Indonesia. In addition, the substance of Pancasila is the same as the substance of the Medina Charter and the Hudaibiyah Agreement, namely guaranteeing the social, political, religious, and cultural rights of the community for the unity and integrity of the people. In addition, the values contained in Pancasila are the values taught by Islam, so rejecting Pancasila as the State foundation is the same as rejecting the teachings of Islam. The results of this study contribute to providing an understanding of the relationship between Pancasila and Islam.
Feminist Interpretation and the Struggle for Women's Rights in Public Space
Authors: Solihin Khabib , Aksa Ahmad Habiburrohman , Latifah Umi , Hasan Dewi Khumaero’
Published: October 2023

Issues regarding gender never end, such as leadership issues and the role of women in the public sphere. Some interpretations of the Qur'an show views that do not fully recognize the human dignity of women. The push to reinterpret verses relating to gender to realize gender justice was carried out by Muslim intellectuals with feminist views. Among them, Amina Wadud Muhsin was challenged to fight for the reinterpretation of this problem using the hermeneutic method. The research was carried out by collecting library data, especially Amina Wadud's thoughts on feminist interpretation. Amina Wadud interprets the leadership and polygamy verses to mean that the concept and role of leadership in Islam are not limited to a particular gender. Polygamy is not an ideal form of marriage because it does not allow for the creation of a mutualistic relationship. The methodology used by Wadud critically considers the socio-historical context in which the verses of the Koran were revealed and provides space for a feminist perspective to fight for women's rights.
Economicidade e sustentabilidade influenciam a intenção de compra dos consumidores de café
Authors: Soares Camila Aparecida Lessa , Ferreira Marco Aurélio Marques , Della Lucia Suzana Maria , Minim Valéria Paula Rodrigues
Published: October 2023

Compreender as preferências e o comportamento do consumidor oferece a possibilidade de entender a aceitação ou rejeição de determinados produtos e de incentivar a criação de “marketing sensorial”. Para analisar as hipóteses do estudo de que as características não sensoriais possibilitam a criação de fatores que influenciam a intenção de compra, e de que os consumidores podem ser agrupados em razão dos atributos avaliados no momento da compra, os dados foram submetidos a um estudo exploratório e analisados pela técnica multivariada. Utilizou-se a análise fatorial, para determinar quais atributos são importantes para a decisão de compra de café, e a análise de agrupamento, para definir os grupos dos consumidores da bebida. Participaram do estudo 841 consumidores de café, que responderam a um questionário online. Dois fatores influenciam a decisão de compra, economicidade e sustentabilidade, o que resultou em quatro grupos de consumidores. A segmentação do mercado de café, com base nos atributos importantes no momento da compra, segue uma tendência nacional, pela qual os consumidores que buscam marca, preço e qualidade do produto mostram que estão preocupados com o meio ambiente.
Fatores sociodemográficos associados à alteração do consumo de café como bebida durante a pandemia da COVID-19 no Brasil
Authors: Soares Camila Aparecida Lessa , Crepalde Ludmylla Tamara , Ferreira Marco Aurélio Marques , Della Lucia Suzana Maria , Minim Valéria Paula Rodrigues
Published: October 2023

O Brasil é o maior produtor e exportador de café e o segundo maior consumidor da bebida no mundo. A pandemia da COVID-19 alterou o consumo dos alimentos, entre os quais o café. O objetivo deste estudo foi compreender o consumo de café como bebida (independentemente da forma de preparo) pelos brasileiros, durante a pandemia, e contribuir com o levantamento de características sociais que influenciaram o comportamento dos consumidores naquele período. Realizou-se uma pesquisa online com 841 respondentes, no período de março a agosto de 2022. Foi possível verificar que a pandemia da COVID-19 desencadeou uma alteração de comportamento e, consequentemente, do consumo de café. Encontraram-se efeitos significativos das variáveis idade, região e escolaridade sobre o consumo da bebida na pandemia (p<0,05). Para que a indústria cafeeira e os produtores rurais possam gerar estratégias de marketing, observou-se que é necessário compreender que o aumento do consumo de café como bebida está associado a fatores sociais e vai além dos atributos sensoriais. Como resultado desta pesquisa, um perfil de consumidor foi levantado, o qual pode vir a contribuir para o direcionamento das estratégias de marketing.
JAMBI FOREST HONEY TO INHIBIT CARIOGENIC BACTERIUM STREPTOCOCCUS MUTANS: IN VITRO STUDIES
Authors: Gumilar Mira Sri , Fitria Karin Tika
Published: October 2023

Background: The most important factor that causes caries is dental and oral hygiene. One attempt to maintain dental and oral hygiene is cleaning up plaque on teeth. Except of brushing teeth, many studies shown that gargling with honey could reduce dental plaque score. Method: The design of this study was an in vitro experimental design study with posttest control only design using disk diffusion technique. The Sample of this study was Streptococcus mutans culture bacterium. The sample of this study was divided into five groups, namely the control group, the treatment group with branded honey, the treatment group with branded mouthwash contain of 26,1% alcohol, the treatment group with branded mouthwash contain of 0,2% Chlorhexidine Gluconate, and the treatment group with acacia carpa honey. The data was obtained from the diameter of inhibit zone in Streptococcus mutans. Analysis was done to that data and carried out using the Kruskal Wallis and Mann Whitney tests. Result: The result showed that acacia carpa honey was more effective in inhibiting the growth of Streptococcus mutans bacteria compared to the control group, packaged honey, and brand mouthwash containing 21.6% alcohol. Conclusion: Acacia carpa as Jambi forest honey is effective in inhibiting the growth of Streptococcus mutans bacteria.
DEVELOPMENT OF DENTAL AND ORAL HEALTH CARE IN SPECIALISTIC ORTHODONTY DENTAL SERVICES
Authors: Aulia Wirda , Fatmasari Diyah , Santoso Bedjo
Published: October 2023

Background: One of the dental and oral health problems experienced by Indonesian society is malocclusion with a prevalence of 80%. The role of the Dental and Oral Therapist (TGM) in orthodontic treatment who collaborates with specialist dentists to correct malocclusion so that it functions well is not yet fully effective because the TGM only implements/chair side assistants in the fourth stage when the TGM should carry out all stages of dental and oral health care . So it is necessary to develop dental and oral health maintenance in specialist orthodontic services. Objective: To produce and analyze the effectiveness of implementing dental and oral health care in specialist orthodontic dentistry services. Research Method: The research method used is Research and Development and Quasy experimental research design Pretest-Posttest group design. The research respondents were TGM at the Muhammadiyah University Semarang dental and oral hospital, TGM intervention 10 people were given model training and controls were given care from Permenkes No.284 of 2006. Data collection techniques in this research were interviews, questionnaires and observation. Validation of expert data was tested using the Intraclass Correlation Coefficient (ICC) while the model test was processed using the Wilcoxon and Mann-Whitney tests. Results: Development of dental and oral health care in specialist orthodontic dentistry services that are relevant as dental and oral health care with expert validation results of 80% and p-value 0.002. The test results stated that the implementation of effective parenting increased TGM knowledge with a p-value of 0.005, TGM attitudes with a p-value of 0.004, and TGM skills with a p-value of 0.004. Conclusion: The application of dental and oral health care in specialist orthodontic services is effective in increasing TGM behavior
DENTAL PHANTOM DOLLS: A MEDIA INNOVATION IN TEACHING BRUSHING TEETH TO PRESCHOOL CHILDREN
Authors: Purnama Tedi , Sofian Rizki
Published: October 2023

Dental health problems that many Indonesian people suffer from are dental caries. Poor dental and oral hygiene is one of the factors causing dental caries or dental and oral health problems. Dental and oral health education demonstration method of brushing teeth with phantom dolls can improve teeth brushing skills and dental and oral hygiene status in preschool children. Objective: to analyze the effectiveness of dental health promotion using dental phantom dolls media on brushing skills and dental hygiene status of preschool children. Method: design of this study was pre-experimental This study used a pre-experimental design with a pretest and posttest with two group design. This research was conducted in preschool children in Pondok Labu Village, Cilandak District, South Jakarta City. The sampling technique used purposive sampling as many as 60 students. The research instrument used an observation sheet to brush teeth to measure teeth brushing skills and dental and oral hygiene status was measured using a plaque free score index. The dental health promotion media used in the intervention group was a dental phantom dolls, while the control group used a flipchart. Data analysis used paired sample test, Wilcoxon and independent t-test. Results: The dental phantom dolls was effective in improving tooth brushing skills (p<0.001) and effective in improving the dental and oral hygiene status of preschool children (p<0.001). Conclusion: The dental phantom dolls is effective as a medium for promoting dental health in an effort to increase the tooth brushing behavior of preschool children.
THE EFFECTIVENESS OF COUNSELING USING PUZZLE AND SNAKE AND LADDER GAME MEDIA ON DENTAL CARIES KNOWLEDGE IN ELEMENTARY SCHOOL STUDENTS
Authors: Pay Mery Novaria , Obi Applonia Leu , Nubatonis Melkisedek O. , Pinat Leny M. A. , Eky Yansestina E.
Published: October 2023

Background: Increasing knowledge can be done through dental health education efforts, namely counseling to provide information to the community. Efforts to increase knowledge can be given a stimulus through educational games to sharpen children's brains and make children creative because the world of children is a world of play. To support playing and learning activities, media is needed that can be interesting according to the characteristics of children's development. The aim of the study was to determine the effectiveness of counseling using puzzle game media and snakes and ladders on dental caries knowledge in elementary school students in Taebenu District. The research design uses a quasi-experimental research design with a non-equivalent control group design. Sampling was by purposive sampling, the instrument in the study used a questionnaire and the analysis used SPSS with the Wilcoxon and Mann-Whitney tests. The results of the study: there is a significant difference in the number of scores between the puzzle media game and the snakes and ladders media game. This is evidenced by the results of the Mann-Whitney test, which obtained a p-value of 0.000 <0.05. From the results of the study it was concluded that there was an increase in the level of knowledge of children who were given games using snakes and ladders media more effectively than children who were given games using puzzle media.
EVALUATION OF MAGIFRESH MOUTHWASH MANALAGI APPLE PEEL EXTRACT
Authors: Emini Emini , Erwin Erwin , Widiyastuti Rini , Yusmaniar Yusmaniar
Published: October 2023

Regular dental care and oral hygiene are important steps in maintaining overall body health. Plaque is one of the dental problems that can develop into diseases that are detrimental to oral health. One way to remove plaque is to use preventive dental products. Previous research shows MAGIfresh, which is a 25% manalagi apple peel extract mouthwash, shows good potential as a mouthwash for dental health. Therefore, it is important to conduct further research to test the effectiveness of the product. The purpose of this study was to determine the difference in effectiveness of MAGIfresh mouthwash, mineral water, and mouthwash products on the market against plaque deposits. This type of research is a quasi-experiment. The sample amounted to 62 students majoring in dental health at Poltekkes Kemenkes Jakarta I. The sample was divided into 3 groups, namely A (MAGIfresh mouthwash), B (mineral water mouthwash), and C (market mouthwash). After gargling, the samples were examined for PHP index. Statistical analysis using one way ANOVA. The results showed a PHP index in groups A = 1.51, B = 1.94, and C = 2.37. The results of the analysis of differences between the 3 groups showed a ?-value of 0.034 <0.05. The conclusion of the study is that there is a significant difference in the average PHP Index between the 3 groups, gargling MAGIfresh mouthwash has the same effectiveness as gargling mineral water, and gargling MAGIfresh mouthwash is more effective when compared to gargling one of the mouthwash products from the market.
CADRE ASSISTANCE IN PROMOTIVE AND PREVENTIVE DENTAL HEALTH PROGRAMS IN TRADITIONAL COMMUNITIES OF KAMPUNG NAGA
Authors: Suharja Eliati Sri , Kusmana Aan
Published: October 2023

Kampung Naga is one of the traditional villages in Neglasari Village, Salawu District, Tasikmalaya Regency. The Kampung Naga Traditional Community is known for its strength in maintaining and preserving the traditions of its ancestral heritage. As a traditional village, the lives of its people are inseparable from traditional rules, including regarding health. Self-cleaning activities such as bathing are carried out in the "pacilingan" (MCK) which is above the fish pond. Interestingly, people here do not use cosmetics such as soap, shampoo and toothpaste when cleaning themselves. The ingredients used for bathing and shampooing are "taneuh porang" (clay), crushed orang-aring leaves or aloe vera and some also use lime. Meanwhile, to brush your teeth, use "eurih jeung lebu" (fiber from weed leaves and rubbing ash). The aim of the research is to determine the effect of cadre training in promotive and preventive dental health programs for the Naga village indigenous community in Tasikmalaya Regency. The qualitative research method is a quasi-experimental one group pre and post test design method using an observational approach and implementation of the PAR model which is supported by a literature review. The research results show that training local cadres is very effective in the promotive efforts carried out by cadres in indigenous communities. The results show that the level of pre-post knowledge of indigenous communities has increased to good with a result of p=0.000, and for the preventive results of OHIS measurements, the majority of indigenous community members in Dental hygiene maintenance has implemented what they got from the promotive cadres so that the pre-post OHIS results are good, p = 0.000, there is a significant change in the promotive and preventive efforts above, according to statistics, it is very significant. Conclusion: that there is an influence of cadre training in the promotional and preventive dental health program efforts of the Naga village indigenous community in maintaining the cleanliness of the teeth and mouth of local residents.
МОДЕЛЮВАННЯ СИСТЕМ З СЕЗОННИМИ ТЕПЛОВИМИ АКУМУЛЯТОРАМИ ВІДНОВЛЮВАНОЇ ЕНЕРГЕТИКИ
Authors: Попович О. М.
Published: October 2023

Розроблено, програмно реалізовано й апробовано комплексну математичну модель для проєктного синтезу конструктивних і режимних параметрів систем відновлюваної енергетики з сезонним акумулюванням теплової енергії. Розроблено критерій ефективності цих систем як відношення доходу від продажу одиниці енергії, направленої на акумулювання, до вартості потрібного для цього теплоізоляційного матеріалу. Математична модель забезпечує визначення інтегральної величини цього критерію за сезонний цикл роботи теплового акумулятора з урахуванням сумісного впливу електромеханічного й теплотехнічного обладнання на ефективність системи. Початок математичного моделювання потребує інформації про величину коефіцієнта використання енергії теплового акумулятора як співвідношення енергій: направленої споживачу і на його вході, а також про номінальні дані компресорного агрегату теплового насоса для моделювання втрат у ньому. Ці величини уточнюються за результатами розрахунку циклу роботи для повторної ітерації. Алгоритм дослідження передбачає різні варіанти передачі тепла від теплового акумулятора до системи теплоприйому, залежно від співвідношення їх температур: за допомогою як теплообмінників, так і теплових насосів. До вхідних параметрів, що варіюються, належать: режим роботи й величина сезонного теплоспоживання, температури навколишнього середовища, теплового акумулятора, споживача, системи опалення, параметри теплової ізоляції споживача й акумулятора. За допомогою розробленої моделі виконано порівняльні дослідження ефективності систем теплових акумуляторів у формі паралелепіпеда й кулі, а також при варіюванні обсягів енергії.
Towards the Exploration of the Victorian Literature: The Historical Overview
Authors: Nnyagu Uche , Deborah Umeh
Published: October 2023

The Victorian Period is a remarkable period in the history of literature as a lot of transformations took place in this era. The Victorian Period spaned from 1837 to 1901 and it is a remarkable era that left an indelible mark on the fabric of society, art, and literature. This paper delves into the rich precepts of the Victorian era, exploring its distinctive characteristics, social dynamics, and artistic expressions. This study commences with an overview of the historical and socio-political context of the Victorian Period, highlighting the reign of Queen Victoria and the significant events that shaped the era. It also examines how these influences set the stage for the unique values, beliefs, and attitudes that permeated the Victorian society. A central focus of this study is the exploration of the Victorian social hierarchy, with its rigid class structure and strict moral codes. This era was also marked by a flourishing artistic and literary scene that produced a wealth of literary masterpieces. In exploring the works of prominent Victorian authors such as Charles Dickens, Jane Austen, and the Brontë sisters, it equally explores the thematic underpinnings of their novels, such as social inequality, love, morality, and the changing dynamics of the Victorian society. Additionally, we will discuss the rise of serialized fiction and the influence of Victorian literature on contemporary storytelling. Lastly, this paper sheds light on the legacy of the Victorian Period, exploring its enduring impact on subsequent generations. It also discusses how Victorian ideals and sensibilities continue to shape modern society, art, and literature, as well as their resonance in contemporary discussions on gender, class, and societal norms.
My Darling Hyeonhi, I am not Ashamed of Hearing your Words! (Tcheonzamun 769th-784th)
Authors: Kim Sangdeog Augustin
Published: October 2023

French Missionary Dallet (1874) wrote in his book that ‘The thousand character essay’ was utilized as a textbook for the ancient Chinese children for their learning of Chinese characters. The thousand character essay is called in Korea as Tcheonzamun (Han, 1583). The object of this work is “What is the main theme of total Tcheonzamun?”. The range of this work is for the poem of (Tcheonzamun 769th-784th). There are two methods of translation of Tcheonzamun poem. The first translation is done through Korean pronunciation of Chinese characters on Tcheonzamun (Park et al., 2021b). And the second translation is carried out through the meaning of Chinese character on Tcheonzamun (Park et al., 2021a). The title of this work is ‘My Darling Hyeonhi, I am not ashamed of hearing your words! (Tcheonzamun 769th-784th)’. The theme of this research is as follows. (781-784 凌(Neung) 摩(Ma) 絳(Gang) 霄(So). 781-784 凌(Neung)-冫-夂-冫=土 摩(Ma) 絳(Gang)-夂-小-五=幺 霄(So)-冫-小-五=月). My husband! Being in the heaven as if you were a bird, do you want again to touch (摩) the soil (土)? This state is really great in the world! In order to become such a splendid man. On the contrary your attitude (月) must be modest (幺) to the Lord! My husband! I want that you are kind to me also…
Neonatal Outcome with Magnesium Sulphate and Fentanyl as Adjuvants for Epidural Labour Analgesia: A Prospective Comparative Study
Authors: Rahim Md. Abdur , Mahabubuzzaman Mohammad , Khatun Marufa , Khatun Marufa , Kabir Md. Humayun , Rahman Md. Akkasur , Saddam Abdullah Mohammad , Kabir Humaiun
Published: October 2023

Introduction: The pain of childbirth is arguably the most severe pain most women endure in their lifetime. Since pain relief in labor has always been surrounded by myths and controversies, providing effective and safe analgesia during labor has remained an ongoing challenge. Neuraxial techniques are accepted as the gold standard for intrapartum labor analgesia. The study aimed to determine the neonatal outcome with magnesium sulfate and fentanyl as adjuvant for epidural labor analgesia. Methods: This prospective comparative study was conducted at the Department of Anaesthesia, Analgesia, Palliative and Intensive Care Medicine in collaboration with the obstetric department, Dhaka Medical College, Dhaka.Bangladesh. The study was carried out from October 2020 to March 2021. A total of 60 patients were assigned by computer-generated random table to one group (Group A) and another group (Group B). Group-A (n=30): Group-A received Fentanyl 25 micrograms as adjuvant to bupivacaine (0.5% plain bupivacaine 2.5 ml+25 microgram of fentanyl 0.005% 0.5 ml + 7 ml normal saline=10 ml) via epidural catheter. Group B received MgSO4 50 mg as an adjuvant to bupivacaine (0.5% plain bupivacaine 2.5 ml + 50 mg of MgSO4 10% 0.5 ml +7 ml normal saline=10 ml) via epidural catheter. Data were statistically described in terms of mean ± standard deviation (±SD), or frequencies (number of cases) and percentages when appropriate. Comparison of numerical variables between the study groups was done using the Student t-test for independent samples. For comparing categorical data, a Chi-square (x2) test was performed. P values of less than 0.05 were considered statistically significant. F-value was determined by the Repeated measured ANOVA test where data were repeated more than one time. All statistical calculations were done using the computer program SPSS (Statistical Package for the Social Science; SPSS Inc., Chicago, IL, USA) version 22 for Microsoft Windows. Informed written consent ......
Comparison between Intra-Articular Corticosteroid Injection with Physiotherapy and Corticosteroid Injection Alone in Management of Early Stage Frozen Shoulders: A Randomized Clinical Trial
Authors: Md. Nasiruddin Md. Nasiruddin , Manjur Mushfique , Haque Md. Sazzadul , Islam Md. Jafrul , Hossain Md. Alamgir
Published: October 2023

Introduction: Frozen shoulder (FS) is the most prevalent cause of shoulder pain and impairment, affecting 2-4% of all adults. As an appropriate strategy of treatment for FS, supportive physiotherapy treatment (PT) and exercises within the limits of pain has been recommended. Objective: To compare between intra-articular corticosteroid injection with physiotherapy and corticosteroid injection alone in the management of early-stage frozen shoulder. Methods: This prospective randomized clinical trial study was done among 23 patients with symptoms of early-stage (stage I or II) FS in the Department of Orthopedics, Monno Medical College Hospital from July to December 2022. Two groups were formed out of all the patients. While the other group (non-PT) did not receive any additional physiotherapy treatment, one group did. A follow-up was planned for weeks 6, 12, and 26. Results: Patients who had symptoms for ≥6 months was significantly higher in PT group (81.8%) in comparison to non-PT group (p<0.05). Patients who took physiotherapy treatment was significantly higher in PT group (72.7%) in comparison to non-PT group (p<0.05). The median total SPADI scores in the PT group at baseline, which were 82 (IQR: 35-86) and in the non-PT group, which were 80 (IQR: 65-87), showed the significant pain and limitations of frozen shoulder (FS) in its early stages. Both therapy groups significantly improved at the primary endpoint of 6 weeks for SPADI scores (p<0.05). At 6 weeks compared to baseline, passive ROM increased significantly (p<0.05). Each of the three ROM orientations showed significant changes in favor of the PT group after 12 weeks (p<0.05). At 6 weeks after baseline, both pain scores and Rand-36 physical component scale scores significantly increased (p<0.05). Conclusion: In the first 12 weeks of the early stage of frozen shoulder, physiotherapy in addition to corticosteroid injection improves range of motion (ROM) and functional mobility limitations compared ............
Pidana Mati Terhadap Tindak Pidana Terorisme di Indonesia Dihubungkan dengan Tujuan Pemidanaan dalam Perspektif Hukum Positif dan Hukum Pidana Islam
Authors: Novianti Linda
Published: October 2023

Penelitian ini menganalisis efektivitas penjatuhan pidana mati bagi tindak pidana terorisme di Indonesia serta perspektif hukum positif dan hukum pidana Islam mengenai hal tersebut. Penelitian ini menggunakan teori negara hukum, sistem peradilan pidana, dan pemidanaan. Metode penelitian yang digunakan adalah yuridis normatif dengan pendekatan perbandingan hukum, sosiologis, historis, dan filosofis. Hasilnya menunjukkan bahwa penjatuhan pidana mati dilakukan karena alasan keadaan khusus yang mengancam ketertiban hukum dan sebagai the rights of the social defense. Namun, penjatuhan pidana mati belum efektif dalam pencegahan aksi terorisme karena hanya berfokus pada counter terrorism. Dalam hukum positif, penjatuhan pidana mati masih relevan dengan tujuan pemidanaan dan tidak bertentangan dengan UUD 1945 maupun hak asasi manusia. Dalam hukum pidana Islam, penjatuhan pidana mati dianggap sesuai karena terorisme termasuk kedalam kategori hirabah, yang sanksinya berupa hudud atau had.