bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Waktu Penyangraian Terhadap Karakteristik Fisikokimia Kopi Bubuk Robusta Menggunakan Mesin Roasting Elektrik
Authors: Darajat Aditya , Rifqi Muhammad , Nurlaela Raden Siti
Published: December 2023

The quality of coffee powder can be improved if the main stages of the roasting process can be carried out optimally. Hot air-type roasting machines with a combination of 10 minutes and a temperature of 200 C can produce high-quality coffee powder. Therefore, other research is needed using different types of roasting machines and coffee powder quality criteria based on standards set by the government. The electric roasting machine consists of a Teflon heating mat that is directly integrated with temperature-adjustable heating components and has an automatic stirrer. The study used a one-factor Complete Randomized Design (CRD) with four treatment levels and two repeats. The Roast time of robusta coffee beans at a temperature of 200 C with levels (10, 15, 20, and 25) minutes is factor A. The criteria for testing the quality of coffee powder produced by the electric roasting machine state (smell, color, taste) with normal test results, water content ranges from 1.47-5.29%, ash content ranges from 3.53-3.83%, coffee juice ranges from 24.1-25.6%, and caffeine ranges from 1.66-1.78%. Electric roasting machines at a temperature of 200 C and 10 minutes are the best combination of treatment because the ground coffee produced is quality. I am referring to SNI 01-3542-2004 criteria for criteria tested with the most optimal electrical energy efficiency
Effect of Brewing Time on the Psychochemical and Antioxidant Activity of Green Tea Bag
Authors: Ayuningtyas Ukhti , Rufaida Zahrah , Septiani Widya Prasetyawati , Shabri  , Harianto Sugeng , Maulana Hilman , Prawira-Atmaja M. Iqbal
Published: December 2023

Teabags are commonly used because of their practical use and benefits as antioxidants. However, there are still few studies that report the effect of brewing time of tea bags on their bioactive compounds. This study aims to determine green tea bags' psychochemical properties and antioxidant activity with different brewing times (1, 3, 5, 7, 9, 12, and 15 minutes). The results showed that the length of steeping time influenced the increase in total polyphenols, flavonoids, and antioxidant activity in green tea bags. The highest rehydration ratio value for product A was in the 3rd minute, which was 3.74 g/g, while in product B, it was 3.36 g/g at the 15th minute. In contrast, the highest swelling rate value occurred in the 15th minute with 372.79% and 236.31% in products A and B, respectively. Products A and B had the highest total flavonoids at 12 minutes of brewing time with 132.41 mg Q.E/g and 144.63 mg Q.E/g, respectively. Product A had the highest free radical inhibition activity at the 7th minute, while product B at the 9th-minute steeping was 56.54% and 73.73%, respectively. Pearson Correlation shows a positive correlation between total polyphenols, flavonoids, and antioxidant activity in green tea bags. The results of this study are expected to be a reference and education of reasonable green tea brewing procedures for consumption by the public.
Deteksi Marker Genetik dari Sekuen Protein Hewan untuk Autentikasi Halal Melalui Pendekatan Bioinformatika
Authors: Amaniyah Maghfirotul , Febrita Ruth Ema , Prasetyo Junaedi Adi
Published: December 2023

Keamanan pangan berupa aspek halal menjadi kebutuhan primer bagi masyarakat Indonesia. Studi bioinformatika menawarkan pendekatan untuk analisis materi genetik organisme dari database yang telah tersedia secara luas. Penelitian ini bertujuan untuk menemukan marker dari sekuens protein beberapa sampel kelompok mamamlia secara in silico dengan pendekatan bioinformatika. Pemilihan sampel urutan protein didasarkan pada protein yang telah banyak dilaporkan secara luas yaitu protein IGF2 (insulin like growth factor 2) dan CytB (cytochrome B). Analisis kekerabatan antar sampel menggunakan konstruksi pohon filogenetik berdasarkan sekuens protein sampel spesies mamalia halal yang dibandingkan dengan sampel mamalia non-halal seperti babi dan anjing. Tahap terakhir adalah analisis struktur dan sifat fisikokimia protein target untuk menentukan marker 'halal'. Analisis pohon filogenetik menunjukkan bahwa spesies babi menempati kelompok yang berbeda dengan mamalia yang umum dikonsumsi di Indonesia dan paling dekat hubungannya dengan spesies anjing. Prediksi sifat protein sampel memberikan informasi kesamaan titik isoelektrik dan karakteristik kelarutan antara sekuens protein spesies babi dan anjing. Dua blok penanda pada sekuen babi dan anjing dari protein IGF2 didapatkan dengan metode multiple sequence alignment berupa urutan YDTWKQSAQRLRRGLPALLRARRGR dan HGGASPEASG. Temuan tersebut dapat menjadi penanda baik secara struktur (urutan) maupun posisinya sebagai acuan dalam pengujian produk halal berbasis DNA, khususnya dengan metode PCR.
Diversifikasi Olahan Sidat menjadi Produk Unagi Pastry
Authors: Wittriansyah Khoeruddin , Kristiningsih Ari
Published: December 2023

Eel has a high nutritional content. The process of processing fillets and making kabayaki leaves waste eel fish bones. There are not many variations of processed eel and there is potential for using eel bones, so diversification efforts need to be made. This study aims to make processed pastry using bone flour and eel meat. Pastry dough made from wheat flour is added with eel flour, and eel meat with 3 variables; P1, P2, and P3. P1 was (5% bone flour and 25% eel meat), P2 was (7.5% bone flour and 30% eel meat) and P3 was (10% bone flour and 35% eel meat). Bone flour and eel meat were analyzed proximately to determine their nutritional content. Hedonic organoleptic analysis including taste, aroma, texture, and appearance was carried out on unagi pastry P1, P2, and P3. The results showed that the eel bones contained a high protein, (31.82%) and a low water content (3.37%). Eel meat contains 41.72% protein and 15.98% crude fat. Organoleptic results showed the panelists preferred Unagi Pastry P1 both in terms of taste (3.48), aroma (3.46), texture (3.42), and appearance (3.92).
Eksplorasi Pengaruh Kesediaan Membayar Layanan Logistik Halal terhadap Perpanjangan Sertifikat Logistik Halal: UMKM Sektor Pertanian
Authors: Jatnika Muhammad Dzulfaqori , Andani Listia , Faqihuddin  , Bunda Cici Aulia Permata
Published: December 2023

The first period of halal certification obligations according to Undang-Undang Nomor 33 Tahun 2014 and its derivatives will end on October 17, 2024, including food and beverage products. Therefore, the halal certification process for products of micro, small, and medium enterprises needs to be carried out promptly. The aim of this research is to examine the factors influencing the willingness of agricultural commodity-based UMKM players to pay for halal logistics services. This study employs a quantitative approach with purposive sampling for data collection and SEM-PLS for data analysis. The research includes 350 respondents who are UMKM players based on agricultural commodities. The findings of this study reveal that, in addition to the variable knowledge on halal, other variables such as concern on halal, awareness on halal, perception of halal logistics, and service capability have a positive and significant influence on the willingness to use halal logistics services. Furthermore, the willingness to use halal logistics services can encourage halal logistics service providers to renew their halal logistics certificates. The research findings will be beneficial for policymakers and managers of halal logistics companies as it helps them understand the factors that drive the adoption of halal logistics services.
Analisis Risiko Halal Supply Chain Produk Otak-otak Bandeng Bu Afifah Menggunakan Metode House Of Risk
Authors: Rizqi Akhmad wasiur , Ummah Nur Hidayatul , Yuliana Sukma Dwi
Published: December 2023

Produk otak-otak bandeng bu afifah adalah Usaha kecil dan menengah yang bergerak pada makanan olahan ikan bandeng di kota Gresik Jawa Timur. Berkembangnya industri pangan serta kota Gresik menjadi salah satu destinasi wisata halal Jawa Timur menjadikan UKM Produk otak-otak bandeng bu afifah dituntut dapat mempertahankan kualitas produk dan menyediakan produk yang terjamin halal. Proses bisnis menciptakan produk halal tentunya memiliki peluang risiko disetiap tahapannya. Manajemen risiko berfungi untuk mengidentifikasi risiko yang berpeluang terjadi. Supply chain operation reference (SCOR) merupakan pemetaan aktivitas identifikasi risk event dan risk agent. Risk event dan risk agent yang diketahui diukur dampak kejadian, frekuensi kejadian korelasinya dilakukan dengan House of Risk. HOR 1 berfungsi sebagai penentu prioritas penangganan agen risiko dan HOR 2 berfungsi mengetahui prioritas mitigasi yang dilakukan. Didapatkan penyebab risiko menggunakan SCOR rantai pasok Ukm otak-otak bandeng bu afifah terdapat 15 kejadian risiko dan 12 Agen risiko. HOR 1 menghasilkan 4 risiko terbesar yakni A1, A5 A2, dan A3. HOR 2 terdapat 8 usulan PA1 Merancang serta mengimplementasikan Standart Operasional Prosedur pengadaan bahan baku & Proses Produksi yang baik, benar & halal dengan nilai total effectivness 29349, Degre of difficulty 3, Effectivness to Difficulty 9783
HOSPITAL WASTE – LEGISLATIVE FRAMEWORK AND MANAGEMENT DIFFERENTIATIONS IN AUSTRIA, BELGIUM, GERMANY AND GREECE
Authors: Mahnik Susanne N. , Hoffmann Marc , Fraeyman Norbert , Komilis Dimitrios
Published: December 2023

In this paper, the differences regarding hospital waste management, specifically regarding the legal and technical situation and the definition of hazardous hospital waste in four member states (Austria, Belgium, Germany and Greece) are presented. All countries follow the legal guidelines of the European Union, but the technical situation, especially the possibilities for thermal waste disposal in incineration plants are different. Also, the definition and categories of hazardous medical wastes is different in the aforementioned four EU member states. The annual production amounts of medical waste in selected countries are presented, as well as criteria that lead to their classification as hazardous medical waste.
EVALUATION OF DUST EMISSION RATE FROM LANDFILL MINING ACTIVITIES
Authors: Zari Mohammed , Smith Richard , Ferrari Rebecca
Published: December 2023

Mining operations are one of the most significant sources of particulate emissions in the atmosphere. Landfill mining (LFM) process activities, including excavation, screening, shredding, and equipment handling, have the potential to emit particulate matter into the environment as short-term episodic emissions during operational periods. Previous investigations show that LFM activities can potentially cause human health and environmental impacts through exposure of these emissions. This paper evaluates the dust emission rate of such activities to understand factors responsible for higher emissions rate and determine where any pressure points exist in order to mitigate risk. Nine empirical formulas were adopted from surface mining activities, including point, line, and area sources of activity. Parameters identified in the equations were adjusted to LFM application conditions. From emission results, it is observed that point source activities were the major sources of emission. The study area was divided into multiple phases and one phase cumulative for the maximum/average/minimum point sources emissions over the lifetime of the landfill mining operation calculated in this study are approximately 5.04 tonnes (t) / 3.23 (t) / 1.61 (t), respectively. However, the one phase cumulative for the maximum/average/minimum line sources emissions over the lifetime of the landfill mining operation are approximately 100.8 (kg/m) / 40.32 (kg/m) / 20.16 (kg/m), respectively. Mitigation measures to control high emission rate of LFM related activity, such as utilising tankers or bowsers to spray water around the LFM area, to control airborne emissions, should be considered. The results of this research are expected to inform air dispersion modelling for environmental impact assessment studies of air pollution.
Classification of soils of Ukraine
Authors: Polupan M.I. Polupan M.I. , Solovei V.B. Solovei V.B. , Velychko V.A. Velychko V.A.
Published: December 2023

The book presents the genetic, ecological and substantive classification of the soils of Ukraine on a parametric basis. Indicators of the ecological and genetic status of soils in the system of structural organization of the pedosphere are theoretically substantiated, new achievements about the genetic nature of soils are given, and the possibility of discrete parame­ terization of the soil continuum is proven. The principles of classification and its taxonomic units with quantitative diagnostic indicators are considered. Nomenclature and diagnostics of genetic horizons are given. The characteristics of soil types in the system of supertypical units are presented according to the conditions of formation, profile structure, morphological and genetic features, and quantitative diagnostic indicators, and their distribution according to lower taxonomic units according to parametric criteria. For scientists, teachers, graduate students, and students of agricultural, biological and geographical specialties of higher educational institutions and a wide range of specialists when conducting soil, agrochemical, and other research of soil cover and works related to its land cadastre, fertility assessment, and rational use
The Turkish Constitutional Court During the State of Emergency Between 2016 and 2018
Authors: Yıldırım Engin
Published: December 2023

This article investigates the judicial approach of the Turkish Constitutional Court (TCC) during the period of state of emergency between 2016 and 2018 in Türkiye. Like its counterparts facing similar challenges, the TCC has endeavored to strike a balance between defeating grave threats to the constitutional system and defending fundamental rights in a time of public emergency. While constitutional courts should try to protect constitutional rights from executive abuse of emergency powers, they should do so without jeopardizing the effectiveness of these measures in countering threats to the nation. During the period of state of emergency, the TCC adopted a deferential stance in its constitutionality review cases arising from its textualist interpretation of the constitution, which explicitly prohibits the review of emergency decrees. However, the Court embraced a posture of rights protection in its individual applications procedure, which requires the TCC to follow case law of the European Court of Human Rights (ECtHR).
The Role of The Indonesian Constitutional Court in Preventing Social Conflict in A Diverse Society
Authors: Ristawati Rosa , Salman Radian
Published: December 2023

In the diverse society of Indonesia, the Constitutional Court plays a vital role in maintaining social harmony and preventing social conflict. Although this contribution is largely indirect, the Court exerts significant influence through its decisions. Since its establishment in 2003, the Court has rendered over 1,000 decisions, many of which carry profound implications for Indonesian society. This article addresses how the Constitutional Court, through its decisions, has contributed to mitigating social conflicts and fostering equilibrium within the nation’s diversity. To analyze this main issue, a normative approach grounded in the nation’s laws and the Constitutional Court’s decisions will be employed. Several decisions, especially on judicial reviews and election disputes, will be examined to illustrate the Court’s role in minimizing social conflict. From a social theory perspective, the study of social conflict has relevance in the context of law and society, given the potential for various types of conflicts in Indonesia’s diverse society. The legal basis for addressing social conflicts in Indonesia is the 2007 Law on Social Conflict Management. According to this law, social conflicts may arise from various factors, including political issues, economic disparities, socio-cultural differences, inter-religious or inter-ethnic tensions, disputes over boundaries at the village, regency/municipal, or provincial levels, conflicts related to natural resources, and disparities in the distribution of these resources within society. The Constitutional Court indirectly plays a role in preventing social conflicts. Nevertheless, the Court faces challenges in fulfilling this role. Pressures from various parties and interests may hinder its ability to ensure constitutional justice, potentially compromising its principles of independence and impartiality in fulfilling its mandate.
Taraxacum erythroboreale (Asteraceae), a new species of presumably intersectional hybrid nature with broad distribution in North European Russia (Taraxacum Notulae Rossiae Boreali Europeae II)
Authors: Efimov P. G.
Published: December 2023

Taraxacum erythroboreale Efimov, a new apomictic species, is described and illustrated. It occurs in Russia (North of the European part), in the Murmansk and Vologda regions, in the Komi Republic, being locally very abundant. It occupies mainly dry sandy roadsides and other similar ruderal places, and seems benefiting from the anthropogenic disturbance of the land. The new species may belong either to the section Erythrosperma (H. Lindb.) Dahlst., or have originated from the hybridization between this section and some species of an Asiatic section like Stenoloba Kirschner et Štěpánek or Dissecta (Soest) R. Doll. The new species displays rather wide morphological polymorphism as to the presence/absence of purplish achene pigmentation, shape of outer phyllaries, corniculation of phyllaries, and in some other traits.
Feminismo Negro no Meio Digital em Portugal
Authors: Rua Inês
Published: December 2023

Os feminismos têm assumido diferentes contornos, suscitado diversas temáticas e abarcado vários palcos. Atualmente, vivemos um período histórico onde os media digitais assumem um importante papel: as mulheres encontraram novos espaços de empoderamento, resistência e participação, nos mais diversos âmbitos. Se os feminismos negros e as pessoas que durante séculos travaram as lutas nacionais nas reivindicações pela igualdade de género e de raça permanecem na penumbra, por outro lado, uma nova geração de ativistas tem feito uso das redes sociais para desencadear a possibilidade da existência de uma nova vaga feminista negra em Portugal. A presente investigação pretende analisar os feminismos negros em Portugal na sua confluência com as redes sociais, para responder à pergunta: quais as principais reivindicações do feminismo negro Portugal por meio dos perfis @quotidianodeumanegra e @umafricana? Assim, propomo-nos tecer uma análise de publicações em duas páginas da rede social Instagram de pessoas que se dedicam à partilha de conteúdos relacionados com o tema que aqui nos prende. Para tal, recorreu-se metodologicamente à análise temática crítica, conforme enunciada por Lawless e Chen (2019), aliando-se também uma abordagem crítica feminista com inspiração na interseccionalidade como método crítico definido por Collins (2019).
KLASIFIKASI MERIAM TRADISIONAL NUSANTARA: STUDI HISTORIS KOLEKSI MUSEUM PERJUANGAN SUBKOSS GARUDA SRIWIJAYA
Authors: Susetyo Berlian
Published: December 2023

Sebagai bangsa yang besar, Indonesia memiliki kekayaan dan keberagaman budaya yang menghasilkan berbagai benda seni karya manusia, termasuk senjata-senjata tradisional. Salah satu contohnya adalah meriam, sebuah jenis senjata api berat dengan laras besar berbentuk tabung, menggunakan bubuk mesiu atau bahan pendorong lainnya untuk menembakkan proyektil peluru. Meriam, sebagai bagian dari warisan senjata tradisional Nusantara, kini menjadi bagian dari koleksi Museum Perjuangan Subkoss Garuda Sriwijaya di Lubuklinggau. Penelitian ini menggunakan metode sejarah dengan langkah-langkah seperti heuristik, verifikasi, interpretasi, dan historiografi. Untuk menganalisis data, pendekatan arkeologi digunakan untuk memeriksa benda-benda peninggalan sejarah guna mengungkap fakta di balik benda-benda tersebut. Fokus penelitian ini adalah mengklasifikasikan koleksi meriam berdasarkan nilai-nilai sejarah. Dua meriam yang dibahas dalam penelitian ini adalah: 1). Meriam Lela Ekor Lutung. 2). Meriam Kecepek. Kedua meriam ini memiliki karakteristik dan desain yang berbeda dalam hal teknologi pembuatan dan penggunaan senjata api di dunia Melayu Nusantara, sehingga masing-masing memiliki fungsi yang berbeda dalam setiap penggunaannya.
Effect of colour on wind turbine blade performances
Authors: Anzanello Ivan
Published: December 2023

The present work is a first analysis of the impact of colour on the aerodynamic efficiency and power of a wind turbine. In wind farms, a blade is colored as a solution to reduce the possibility of bird impact.The study of the scientific documentation shows that colour has a positive effect on aspects as aerodynamics efficiency and noise, especially in plants on land where the need for greater maintenance is less expensive than in offshore plants.
PENGARUH PERBANKAN SYARIAH TERHADAP PEREKONOMIAN DI INDONESIA
Authors: Yuniar Ashey
Published: December 2023

Bank Islam atau bank syariah, yang dikenal sebagai bank tanpa bunga, merupakan lembaga perbankan yang beroperasi berdasarkan prinsip syariat Islam, dengan fokus pada pembiayaan dan jasa-jasa dalam lalu lintas pembayaran. Prinsip-prinsip syariah Islam menjadi panduan utama dalam operasional bank ini, terutama dalam tata cara bermuamalah sesuai dengan hukum Islam. Beberapa contoh bank umum syariah di Indonesia meliputi Bank Syariah Mandiri, Bank Syariah Bukopin, dan Bank Muamalat Indonesia.Perkembangan layanan perbankan syariah semakin meningkat di Indonesia, menjadi sistem perbankan yang dikembangkan berdasarkan prinsip syariah. Larangan umat Islam terhadap riba dan investasi pada kegiatan-kegiatan yang dianggap haram menjadi pendorong utama dalam pembentukan sistem perbankan syariah. Menurut Otoritas Jasa Keuangan (OJK), bank syariah di Indonesia dibagi menjadi dua jenis, yaitu Bank Umum Syariah (BUS) dan Bank Keuangan Syariah Rakyat (BPRS), dengan perbedaan layanan yang disediakan. Undang-undang No. 21 tahun 2008 tentang Bank Syariah memberikan definisi bahwa bank syariah adalah bank yang melakukan kegiatan usaha berdasarkan prinsip syariah atau hukum Islam. Prinsip syariat Islam mencakup keadilan, keseimbangan, universalisme, dan kemaslahatan.Bank Muamalat Indonesia (BMI) menjadi pelopor sistem perbankan syariah di Indonesia, didirikan pada tahun 1991 oleh Majelis Ulama Indonesia (MUI). BMI beroperasi berdasarkan prinsip syariah, mencari keuntungan dengan mematuhi peraturan Bank Indonesia dan melarang penggunaan instrumen yang bertentangan dengan syariah. Bank ini harus mematuhi prinsip kehati-hatian dalam menjalankan aktivitasnya untuk mempertahankan status operasional yang baik dan memenuhi kriteria bank yang sehat.
The Quantitative Checklist for Autism in Toddlers (Q-CHAT) and Q-CHAT-10: A psychometric study in Chilean Toddlers
Authors: Gatica-Bahamonde Gabriel
Published: December 2023

The aim of this study was to examine the psychometric properties of a culturally adapted version for Chile of the Quantitative Checklist for Autism in Toddlers (Q-CHAT Full item) and its abbreviated version (the Q-CHAT-10) in a community sample of Chilean children aged 18 to 24 months. An intentional non-probabilistic sampling was used. One hundred eighty-eight young children were examined. Evidence of construct validity was determined through Exploratory Factor Analysis (EFA), evidence of convergent validity with the Modified Checklist for Autism in Toddlers, Revised with Follow-up (M-CHAT-R/F), evidence of reliability through internal consistency and test-retest and finally, evidence of predictive validity through ROC curve analysis. The EFA showed a two-factor structure: "Communication and social interaction" (factor 1) and "Restrictive and repetitive patterns" (factor 2) and explained 37.7% of the variance. This factor structure excluded item 18, thus structuring a narrower version: the Q-CHAT-24. The total scores of the Q-CHAT Full Item, the Q-CHAT-24 and the Q-CHAT-10 correlated positively and significantly with the total scores of the M-CHAT-R/F (r=0.59; r=0.63; and r=0.79, respectively). The internal consistency was acceptable for the Q-CHAT complete item (α=0.74), for the Q-CHAT-24 (α=0.76) and for the Q-CHAT-10 (α=0.75). The internal consistencies of the Q-CHAT-24 factors were good for factor 1 (α=0.86) and acceptable for factor 2 (Cronbach ́s α=0.76). Regarding test-retest stability, the intraclass correlation coefficient was good (ICC=0.86, p<0.001). The cut-off points were established according to the optimal levels of Sensitivity/Specificity and Youden Index and were: 41 for the Q-CHAT Full item version (84.3/81.8, 0.70), 38 for the Q-CHAT-24 (93.7/81.8, 0.76), and 2 for the Q-CHAT-10 (87.5/90.7, 0.78). In accordance with the objectives of this study, evidence of reliability and validity was demonstrated for three versions of the Q-CHAT. The Q-CHAT-24, the version obtained by EFA from the Q-CHAT Full item, is phenomenologically concordant with the DSM-5 dimensional criteria for autism and is psychometrically adequate in terms of its predictive ability to be considered as a screening instrument in the general population. In the same vein, the Q-CHAT-10, a smaller version of the Q-CHAT Full item, stands out as a useful version for a general population setting, given its psychometric characteristics and length.
Is the Formal Framework of Quantum Mechanics Needed to Model Creative Thought?
Authors: Gabora Liane , Pothos Emmanuel , Bashmakova Iana
Published: December 2023

The quantum cognition approach draws upon a mathematical framework originally developed for quantum mechanics. One phenomenon that is particularly well captured by quantum models but not classical ones, known as the Question Order Effect, is that the order of questions can alter the answers given. This paper describes at a layperson level a study that uses this effect to ascertain whether creative thinking and the processing of unfamiliar stimuli both elicit cognitive states and processes that are best described by a quantum model. The rationale is that both involve key quantum features that the quantum formalism is particularly well-suited to capture: ambiguity and contextuality.
Innovative Approaches in Ovarian Cancer Research and Treatment
Authors: Tobiloba Bamigboye , Kelvin Kelly , Tera Terry
Published: December 2023

This comprehensive article delves into the forefront of ovarian cancer research and treatment, emphasizing the transformative impact of innovative approaches across genomics, immunotherapy, and nanotechnology. Genomic research is elucidating the intricate molecular landscape of ovarian cancer, unraveling distinct subtypes and identifying potential biomarkers for early detection. Concurrently, immunotherapy is emerging as a game-changer, harnessing the body's immune system to target and eliminate ovarian cancer cells with heightened precision and reduced systemic toxicity.In parallel, nanotechnology is revolutionizing drug delivery systems, presenting a groundbreaking avenue for enhanced treatment efficacy. Nano-sized carriers facilitate targeted delivery, minimizing off-target effects on healthy tissues and maximizing therapeutic impact on ovarian cancer cells. This section explores the potential of nanotechnology in optimizing drug delivery, with implications for personalized medicine in ovarian cancer treatment.The article also underscores the pivotal role of interdisciplinary collaborations, where the intersection of biology, engineering, and computational sciences is driving unprecedented advancements. Collaborative efforts are dismantling traditional research silos, fostering a holistic understanding of ovarian cancer and facilitating breakthroughs in treatment strategies. The synergistic integration of these innovative approaches offers a promising trajectory for the future of ovarian cancer care.As the field stands on the brink of transformative breakthroughs, this article provides a roadmap for researchers, clinicians, and policymakers alike. The collective impact of genomics, immunotherapy, nanotechnology, and interdisciplinary collaborations holds the potential to reshape ovarian cancer care fundamentally. With renewed hope and optimism, this exploration into innovative approaches lays the foundation for more effective, targeted, and personalized treatments, ushering in a new era in the fight against ovarian cancer.
MANAJEMEN STRATEGIK: STRATEGI BISNIS NAIK KELAS DENGAN BUSINESS MODEL CANVAS (Panduan untuk Mahasiswa, Entrepreneurs, UKM dan Start Up Pemula)
Authors: Awaluddin Robi
Published: December 2023

Perubahan merupakan suatu keniscayaan dalam kehidupan dan saat ini hampir dalam semua sektor sedang mengalaminya. Saat ini, para ilmuwan sudah tidak lagi berbicara tentang globalisasi, namun lebih dari itu, adalah potensi yang luar biasa dalam adanya integrasi yang terjadi antara produk, bisnis dan teknologi yang saat ini telah memasuki revolusi industry 4.0.
Comparative Computational Study on Molecular Structure, Electronic and Vibrational Analysis of Vinyl Bromide based on HF and DFT Approach
Authors: Ojha Tulsi , Limbu Susmita , Shrestha Prakash Man , Gupta Suresh Prasad , Rai Krishna Bahadur
Published: December 2023

In this study, we have used the Hartree-Fock and Density Functional Theory method of calculation and compared the equilibrium configuration, electronic and vibrational mode of Vinyl Bromide molecule. The molecule is geometrically optimized initially by using 6-31G basis set with B3LYP functional and then bond angles, bond lengths, dihedral angles and IR spectra are compared respectively. Various groups of atoms in Vinyl Bromide molecule by DFT has more accurate bond length, bond angle values rather than by HF computation when comparing with the experimental values. The ground state energies are found at angle 10° or 180° or 360° using HF and DFT method of calculation for the H4-C1-C2-Br6 position. Values of the carbon-hydrogen, carbon-carbon and carbon-bromine bond lengths and bond angles for optimization state of C2H3Br molecule using Hartree-Fock and Density Functional Theory methods with respect to the basis set 6-31G have been analyzed. The C−H in-plane bending vibration and C−H out-of-plane bending vibrations occur in the region 1400–1050 cm-1 and 1000–675 cm-1 respectively. The electronic properties, such as Highest Occupied Molecular Orbital and Lowest Unoccupied Molecular Orbital energies are performed by HF and DFT approach and the difference in Highest Occupied Molecular Orbital and Lowest Unoccupied Molecular Orbital energy gap for HF and DFT method are 14.0847 eV and 6.8994 eV respectively
Feasibility study of Replacing Currently used Freons with Ammonium Chloride and Barium Hydroxide for Freezing System
Authors: Rasaili Prithivi , Bhattarai Ajaya
Published: December 2023

The machinery used to cool or freeze food uses a lot of energy. Consequently, it is necessary to lower energy use. Additionally, due to their significant global warming potential (GWP), traditional refrigerants must be replaced to help reduce greenhouse gas (GHG) emissions. Therefore, the usage of alternative refrigerants with lower GWPs is necessary. The possibility of the ammonium chloride (NH4Cl(s)) and solid hydrated barium hydroxide (Ba(OH)2.8H2O(s)) based non-freon refrigerant as a substitute refrigerant was evaluated in this study. Demo-tests were conducted using a prototype refrigerator, which is essentially a closed chamber with foam and PVC insulation. Despite reaching the freezing point satisfactorily, the stirring chamber of the prototype had an unpleasant ammonia odor. Due to the lack of equilibrium between the reactant and product, these components were not permanent solutions like freons. Therefore, further research is needed to determine how effective it would be as a refrigerant
Suitability Analysis of Drinking Water from The Springs of Deumai Watershed Ilam, Nepal
Authors: Shrestha Priya Darshan , Khanal Manoj , Shilwal Champak Babu
Published: December 2023

Spring is one of the major sources of drinking water in hilly and Himalayan region. The overall purpose of this study was to analyse the suitability of drinking water by studying the physicochemical properties. Springs of Deumai watershed Ilam, Nepal was investigated for water samples and the physicochemical parameters studied were TDS, pH, temperature, total hardness, alkalinity, total iron and major ion concentrations (Na+, K+, Mg2+, Ca2+, Cl–, SO42–, NO­3–) to describe the water’s chemical characteristics. The physical parameters were determined using pH meter, laboratory thermometer etc. The determination of concentration of chemical parameters was performed by using spectrophotometric method, flame photometric method and titration method. The average pH was found 7.47 and average temperature was found to be 19.4ºC. The dominance trend for major cations was Ca2+ > Na+ > Mg2+ > K+ > Fe and for anions was HCO3– > Cl– > NO3– > SO42–. All the values obtain were within the range specified by WHO and NDWQS guidelines of drinking water. According to the findings and comparison with the guidelines of drinking water given by World Health Organization (WHO) and National Drinking Water Quality Standard (NDWQS), the water quality for drinking water was found within the standards set by them.
Utilization of Partially Purified Milk Clotting Protease from Ginger Rhizome in the Manufacturing of Fresh Cheese
Authors: Maskey Bunty , Pandey Trilochan , Shrestha Shiva Kumar , Shrestha Nabindra Kumar , Shrestha Megha , Karki Dhan Bahadur
Published: December 2023

This study was carried out to utilize the partially purified ginger rhizome protease in fresh cheesemaking. The crude ginger rhizome extract was partially purified by employing 30-80% (NH4)2SO4 saturations (w/v). The maximum milk clotting activity was achieved at 50% saturation, exhibiting the purification fold of 1.64 and activity recovery of 85.76%. The milk pH and temperature for optimum time of coagulation and milk clotting activity were optimized by using response surface methodology (RSM). A numerical optimization study revealed that the optimum milk pH and temperature for producing cheese were 6.5 and 50 C respectively. The cheese produced by ginger protease had significantly (p<0.05) higher moisture, ash and yield, but lower fat content than the rennet cheese. No significant difference (p>0.05) was found in the calcium and protein content of both cheeses. The prepared cheese using ginger protease had significantly (p<0.05) higher spreadability, but lower aftertaste than the rennet cheese. However, non-significant difference (p>0.05) was observed in the flavor and overall acceptance between the two cheeses. Hence, this study demonstrated that the ginger rhizome protease has the potential to be utilized as an effective milk coagulating enzyme in the manufacturing of fresh cheese.
Knowledge and Practice of Face Mask Use and Handling during COVID-19 Pandemic among Dental Students and Intern at B.P. Koirala Institute of Health Sciences
Authors: Keshwar Shashi , Jain Neetu , Sarraf Deependra Prasad , Shrestha Ashish
Published: December 2023

Background: The outbreak of Corona Virus Diseases (COVID-19) has been deemed a global public health emergency by the World Health Organization (WHO). Face mask is one of the prevalent used methods to reduce the spread of infection. Due to their widespread use, it is crucial to use these masks properly because improper use or disposal could potentially speed up the pace of transmission. The objective was to assess the knowledge and practice of face mask use and handing in undergraduate dental students.
Methods: A web based cross sectional study was conducted among BDS third, fourth, fifth year and interns at College of Dental Surgery, B. P. Koirala Institute of Health Sciences between May-June 2021. A structured proforma was prepared and modified based on relevant literature and expert’s advice. The Google Forms with questionnaires were created using docs.google.com/forms, and the link was shared with the signed-up participants via messaging apps Viber and WhatsApp. Statistical Package for the Social Sciences software, version 21 was used to analyse descriptive statistics such as frequency and percentage.
Results: A total of 144 participants responded to the questionnaire. Eighty-five (59.03%) participants responded that minimum numberof layers in face mask that work better to help stop the spread of COVID-19 outside health care setting is three. Sixty-seven (46.53%) participants responded that they touch front surface of the face mask while wearing it.
Conclusion: Campaigns to raise awareness about the proper use of face masks during this pandemic will be useful in educating dentistry students and interns.
Cryptococcomas: Diagnostic Dilemmas with Increasing Incidence
Authors: Adhikari Bindu
Published: December 2023

Not applicable
Prospective Comparative Study of Above Elbow Cast for Six Weeks Versus Above Elbow Converted to Below Elbow Cast After Three Weeks for Pediatrics Distal Forearm Fracture
Authors: KC Saugat , Gupta Hemant Kumar , Hamal Raj Kumar
Published: December 2023

IntroductionForearm fractures are common injuries and the approach to manage these in children is different than similar injuries in adults. Various methods of cast immobilization are done for the treatment of distal forearm fractures in children. The purpose of this study was to determine if above elbow cast (AEC) converted to below elbow cast (BEC) in three weeks are as effective as above elbow cast (AEC) in the treatment of the distal forearm fracture. Therefore, this study was conducted with the objective of evaluating and comparing the outcome of above elbow cast (AEC) with above elbow converted to below elbow cast (BEC) after three weeks for management of pediatrics distal forearm fracture.
MethodsThis study was conducted in Department of Orthopedic Surgery in College of Medical Sciences-TH Bharatpur, Nepal from February 2016 to January 2017. Among sixty cases thirty were selected in AEC group and thirty in above elbow converted to below elbow cast group (AEC/BEC) by simple random sampling. All patients were followed up six months.
ResultsOut of sixty patients in two groups, fifty-three made to all follow up. Twenty- eight of cases were AEC group and twenty-five were AEC/BEC group. All the cases had union at six weeks and twelve weeks follow up. There was statistically significant difference in limitation in pronation/supination.
Conclusions AEC converted to BEC for six weeks is effective as AEC for six weeks in the treatment of distal third forearm fracture in children. AEC/BEC group patients have lesser degree of loss of supination/pronation movement.
Potential Nephrotoxic Sequel of the Kidney Following Exposure to Turmeric Extract in Adult Wistar Rats
Authors: Ahama Efe , Igben Vincent-Junior Onoriode , Ubogu Joseph , Ifechukwude Ignatius Osakue , Nwabuoku Udoka Shalom , Okwuribo Promise , Kpangban Aghogho , Odokuma Igho Emmanuel
Published: December 2023

IntroductionTurmeric (Curcuma Longa) is a rhizomatous, perennial plant, flowering in nature, belonging to the ginger family. It’s potential therapeutic benefits, has led to an increase in its consumption globally. Despite severe studies on turmeric there is still existing literature gap on the effect of turmeric on the kidney. This study espoused the potential nephrotoxic sequel of the kidney following exposure to turmeric extract in adult wistar rats.
MethodsEthical approval for the study was obtained from the Ethics and Research Committee in the Faculty of Basic Medical Sciences of the Delta State University, Abraka. 24 adult female Wistar rats, weighing between 180g - 200g were used as experimental model. They were grouped into 4 groups (A, B, C and D), and were euthanized at the end of the experimental days and effect of tumeric extract were studied.
ResultsWe found that tumeric extract effect on the kidney histology was unremarkable in all groups with varying doses. Also observed was moderate significant increase in creatinine and urea level in treated groups when compared with control group.
Conclusions Obtained upshot suggests that oral administration of turmeric with graded doses and time dependent showed no microscopic or cytoarchitectural changes, but with a negative functional report.
Efficacy of Silver Diamine Fluoride in Arresting Dental Caries in Primary Teeth in Patient Visiting Tertiary Hospital of Kathmandu
Authors: Gyawali Namrata , Sundas Sunanda , Sah Barun Kumar , Dhakal Neha
Published: December 2023

IntroductionCarious lesions can both be prevented and arrested using fluoride-based materials. This study was done to evaluate and compare the efficacy of silver diamine fluoride in arresting dental caries at different frequencies of applications.
MethodsThis experimental study was conducted among ten preschool children of 3-5 years old with seventy-four active carious lesions taking teeth as a sample unit. Children were randomly allocated into two intervention groups: Group 1— application of 38% silver diamine fluoride solution atthree consecutive weeks and Group 2— three applications of 38% silver diamine fluoride solution at monthly interval. The time taken of caries arrest was recorded. Data were collected and entered in Microsoft Excel sheet and analysis was done in Statistical Package for the Social Sciences (SPSS) version 16. ResultsThe mean time taken for caries arrest for Group II (57.20 days) was found to be statistically longer than Group I (21.54 days) (p-value < 0.001). As the mean time taken for caries arrest for Group I was shorter, the weekly application was found to have higher efficacy than the monthly application. ConclusionsEfficacy of Silver Diamine Fluoride was found to be more in Group I (weekly application) compared to Group II (monthly application).
Health Insurance Utilization Pattern among Community People of Jutpani Kalika Municipality of Chitwan Nepal
Authors: Panthi Srijana , Lohani Suman , Manandhar Alisha , Bansal Prerna , Shrestha Aayasha , Prasai Meera
Published: December 2023

IntroductionThe Government of Nepal's Social Health Security Scheme (SHSS) is a social protection program that strives to give its inhabitants access to high-quality medical treatment without putting a financial burden on them. As a way of achieving Universal Health Coverage, this program makes an effort to overcome obstacles to utilizing health services and assure equity and access for underprivileged and poor populations. Thus, the study aimed to assess the pattern of using health Insurance Schemes by the community people of Central Nepal.
MethodsA cross-sectional, descriptive, prospective study was conducted at Jutpani Kalika Nagar Palika ward No 7. A total of 274 enrolled households were taken using a non-probability, convenient sampling technique. The sample size was calculated by using the formula(n)= z 2pq/e2. Specifically designed proforma were used to assess the pattern of utilizing health insurance schemes. The collected data was entered in SPSS version 16. Descriptive analysis and Chi-square was applied.
ResultsAmong 274 enrolled households, 94.9% have utilized the Social Health Security Scheme (SHSS). Among the study participants, 60.9% had utilized SHSS for laboratory services. The majority of study participants 230(94.7%) were below the poverty line and were utilizing SHSS. The education of the head of the household and the number of earning members in the family were found significantly associated with the utilization of SHSS.
Conclusions The majority of people were utilizing SHSS and they were willing to continue this program and study found that people have faith in government service.
Knowledge and Awareness regarding Strabismus and Amblyopia among School Nurses and Primary School Teachers of Government Schools at Bharatpur
Authors: Shrestha Manisha
Published: December 2023

Background

Strabismus/squint is an ocular misalignment in which the eyes are not properly aligned with each other. Amblyopia is a serious visual impairment resulting from abnormal visual stimulation during early childhood. It can be easily prevented or treated if detected early. This study aimed to assess the knowledge and attitude of school nurses and primary school teachers of Government schools toward children suffering from strabismus and amblyopia.

Method

This was a cross-sectional study among the participating school nurses and primary school teachers of Government school which was organized to raise awareness regarding strabismus and amblyopia among them. It was conducted using a questionnaire which contained 22 items divided into three sections. First section consisted of demographic parameters, second regarding knowledge of strabismus and the third the knowledge of Amblyopia. Data were analysed using Epi info version 7.02 (Centers for Disease Control, Atlanta, Georgia, United States). P-values of <0.05 was used for clinical significance.

Result

There were 67 participants and the mean age was 32.67±7.71 years, range 21 to 55 years, the majority being female 66 (98.51%). Training on eye health was received by 13 (19.40%). Forty-four (65.67%) participants had knowledge of strabismus and amblyopia, out of them 30 were school nurses. The majority of school nurses 23 (76.67%) and primary teachers 13 (92.86%) had good knowledge scores (6 to 10).

 Conclusion

The majority of participants had good knowledge about strabismus and amblyopia. As the school nurses and primary school teachers are the first link to the children at risk, improving their awareness level on strabismus and amblyopia will help in early referral, timely intervention and prevent the risk of vision loss.
Prevalence and Variations of Sesamoid Bones in the Hands of Patients Visiting Teaching Hospital of Kaski District: A Retrospective Study
Authors: Singh Sushma , Sharma Pujan , Sharma Bhoj Raj , Barnawal Kanchan Kumari
Published: December 2023

Introduction: Sesamoids are small, well-corticated, ovoid or nodular, may be bipartite ormultipartite bones/ossifications found close to a bone or a joint that are subject to significant morphological variations. Although it is difficult to determine the symptomatic nature of these bones, imaging provides important diagnostic information. The objective of this study is to assess the prevalence and variations of sesamoid bone in hands of patients visiting a teaching hospital of Kaski district.

Methods: A hospital based retrospective cross-sectional study was conducted by analyzing X-rays of hand with Anteroposterior (AP) view, a total of 150 both male and female patients between the age group of 18 to 85 wereimaged between August 1, 2022 to December 30, 2022 at Department of Radiology & Imaging(X-Ray Unit). Presence of sesamoid bone of hand was noted on 1st, 2nd, 3rd, 4th and 5th metacarpophalangeal joints (MCPj), and the 1st interphalangeal joint (IPj), separately. The data were analyzed for correlation using Pearson’s correlation test.  Ethical approval was taken from the Institutional Review Committee of Gandaki Medical College (Reference No.159/079/080).

Results: The prevalence of sesamoid bone at 1st, 2nd, 3rd, 4th and 5th MCPj, and 1st IPj were 100 (100%), 60 (46%), 24(16%), 20(13.3%), 100(66.7%), and 114(76%) respectively. Variation was more prominent among females at 2nd, 3rdand 5th MCPj and 1st IPj, Also, SB variation was more prominent on left hand compared to right hand in 2nd, 4thand 5th MCPj and 1st IPj.

Conclusions:No significant correlation between the gender and laterality with presence or absence of SB in the hands were noted.