bluuebunny/crossref_metadata_2025 huggingface dataset:
Combined low-pass whole genome and targeted sequencing in liquid biopsies for pediatric solid tumors
Authors: Christodoulou Eirini , Yellapantula Venkata , O’Halloran Katrina , Xu Liya , Berry Jesse L. , Cotter Jennifer A. , Zdanowicz Anya , Mascarenhas Leo , Amatruda James F. , Ostrow Dejerianne , Bootwalla Moiz , Gai Xiaowu , Navid Fariba , Biegel Jaclyn A.
Published: February 2023

We designed a liquid biopsy (LB) platform employing low-pass whole genome sequencing (LP-WGS) and targeted sequencing of cell-free (cf) DNA from plasma to detect genome-wide copy number alterations (CNAs) and gene fusions in pediatric solid tumors. A total of 143 plasma samples were analyzed from 19 controls and 73 patients, including 44 bone or soft-tissue sarcomas and 12 renal, 10 germ cell, five hepatic, and two thyroid tumors. cfDNA was isolated from plasma collected at diagnosis, during and after therapy, and/or at relapse. Twenty-six of 37 (70%) patients enrolled at diagnosis without prior therapy (radiation, surgery, or chemotherapy) had circulating tumor DNA (ctDNA), based on the detection of CNAs from LP-WGS, including 18 of 27 (67%) patients with localized disease and eight of 10 (80%) patients with metastatic disease. None of the controls had detectable somatic CNAs. There was a high concordance of CNAs identified by LP-WGS to CNAs detected by chromosomal microarray analysis in the matching tumors. Mutations identified in tumor samples with our next-generation sequencing (NGS) panel, OncoKids®, were also detected by LP-WGS of ctDNA in 14 of 26 plasma samples. Finally, we developed a hybridization-based capture panel to target EWSR1 and FOXO1 fusions from patients with Ewing sarcoma or alveolar rhabdomyosarcoma (ARMS), respectively. Fusions were detected in the plasma from 10 of 12 patients with Ewing sarcoma and in two of two patients with ARMS. Combined, these data demonstrate the clinical applicability of our LB platform to evaluate pediatric patients with a variety of solid tumors.
Mass spectrometry uncovers intermediates and off-pathway complexes for SNARE complex assembly
Authors: Hesselbarth Julia , Schmidt Carla
Published: February 2023

The SNARE complex assembles from vesicular Synaptobrevin-2 as well as Syntaxin-1 and SNAP25 both anchored to the presynaptic membrane. It mediates fusion of synaptic vesicles with the presynaptic plasma membrane resulting in exocytosis of neurotransmitters. While the general sequence of SNARE complex formation is well-established, our knowledge on possible intermediates and stable off-pathway complexes is incomplete. We, therefore, follow the stepwise assembly of the SNARE complex and target individual SNAREs, binary sub-complexes, the ternary SNARE complex as well as interactions with Complexin-1. Using native mass spectrometry, we identify the stoichiometry of sub-complexes and monitor oligomerisation of various assemblies. Importantly, we find that interactions with Complexin-1 reduce multimerisation of the ternary SNARE complex. Chemical cross-linking provides detailed insights into these interactions suggesting a role for membrane fusion. In summary, we unravel the stoichiometry of intermediates and off-pathway complexes and compile a road map of SNARE complex assembly including regulation by Complexin-1.
Endogenous DAF-16 spatiotemporal activity quantitatively predicts lifespan extension induced by dietary restriction
Authors: Huayta Javier , Crapster Joseph P. , San-Miguel Adriana
Published: February 2023

In many organisms, dietary restriction (DR) leads to lifespan extension through the activation of cell protection and pro-longevity gene expression programs. In the nematode C. elegans, the DAF-16 transcription factor is a key aging regulator that governs the Insulin/IGF-1 signaling pathway and undergoes translocation from the cytoplasm to the nucleus of cells when animals are exposed to food limitation. However, how large is the influence of DR on DAF-16 activity, and its subsequent impact on lifespan has not been quantitatively determined. In this work, we assess the endogenous activity of DAF-16 under various DR regimes by coupling CRISPR/Cas9-enabled fluorescent tagging of DAF-16 with quantitative image analysis and machine learning. Our results indicate that DR regimes induce strong endogenous DAF-16 activity, although DAF-16 is less responsive in aged individuals. DAF-16 activity is in turn a robust predictor of mean lifespan in C. elegans, accounting for 78% of its variability under DR. Analysis of tissue-specific expression aided by a machine learning tissue classifier reveals that, under DR, the largest contribution to DAF-16 nuclear intensity originates from the intestine and neurons. DR also drives DAF-16 activity in unexpected locations such as the germline and intestinal nucleoli.
CircFNDC3B regulates osteoarthritis and oxidative stress by targeting miR-525-5p/HO-1 axis
Authors: Chen Zizheng , Huang Yizhen , Chen Yu , Yang Xiaodong , Zhu Jinjin , Xu Guang , Shen Shuying , Hu Ziang , Shi Peihua , Ma Yan , Fan Shunwu
Published: February 2023

Osteoarthritis (OA) is a common chronic degenerative joint disease associated with a variety of risk factors including aging, genetics, obesity, and mechanical disturbance. This study aimed to elucidate the function of a newly discovered circular RNA (circRNA), circFNDC3B, in OA progression and its relationship with the NF-κB signaling pathway and oxidative stress. The circFNDC3B/miR-525-5p/HO-1 axis and its relationship with the NF-κB signaling pathway and oxidative stress were investigated and validated using fluorescence in situ hybridization, real-time PCR, western blotting, immunofluorescence analysis, luciferase reporter assays, pull-down assays, and reactive oxygen species analyses. The functions of circFNDC3B in OA was investigated in vitro and in vivo. These evaluations demonstrated that circFNDC3B promotes chondrocyte proliferation and protects the extracellular matrix (ECM) from degradation. We also revealed that circFNDC3B defends against oxidative stress in OA by regulating the circFNDC3B/miR-525-5p/HO-1 axis and the NF-κB signaling pathway. Further, we found that overexpression of circFNDC3B alleviated OA in a rabbit model. In summary, we identified a new circFNDC3B/miR-525-5p/HO-1 signaling pathway that may act to relieve OA by alleviating oxidative stress and regulating the NF-κB pathway, resulting in the protection of the ECM in human chondrocytes, highlighting it as a potential therapeutic target for the treatment of OA.
Momentum-resolved electronic structure of LaTiO2N photocatalysts by resonant Soft-X-ray ARPES
Authors: Lawley Craig , Arab Arian , Hartl Anna , Staykov Aleksandar , Döbeli Max , Schmitt Thorsten , Pergolesi Daniele , Lippert Thomas , Strocov Vladimir N.
Published: February 2023

Oxynitrides are promising materials for visible light-driven water splitting. However, limited information regarding their electron-momentum resolved electronic structure exists. Here, with the advantage of the enhanced probing depth and chemical state specificity of soft-X-ray ARPES, we determine the electronic structure of the photocatalyst oxynitride LaTiO2N and monitor its evolution as a consequence of the oxygen evolution reaction. After the photoelectrochemical reactions, we observe a partial loss of Ti- and La-N 2p states, distortions surrounding the local environment of titanium atoms and, unexpectedly, an indication of an electron accumulation layer at or near the surface, which may be connected with either a large density of metallic surface states or downward band bending. The distortions and defects associated with the titanium 3d states lead to the trapping of electrons and charge recombination, which is a major limitation for the oxynitride LaTiO2N. The presence of an accumulation layer and its evolution suggests complex mechanisms of the photoelectrochemical reaction, especially in cases where co-catalysts or passivation layers are used.
Forecasting hospital-level COVID-19 admissions using real-time mobility data
Authors: Klein Brennan , Zenteno Ana C. , Joseph Daisha , Zahedi Mohammadmehdi , Hu Michael , Copenhaver Martin S. , Kraemer Moritz U. G. , Chinazzi Matteo , Klompas Michael , Vespignani Alessandro , Scarpino Samuel V. , Salmasian Hojjat
Published: February 2023

Background

For each of the COVID-19 pandemic waves, hospitals have had to plan for deploying surge capacity and resources to manage large but transient increases in COVID-19 admissions. While a lot of effort has gone into predicting regional trends in COVID-19 cases and hospitalizations, there are far fewer successful tools for creating accurate hospital-level forecasts.

Methods

Large-scale, anonymized mobile phone data has been shown to correlate with regional case counts during the first two waves of the pandemic (spring 2020, and fall/winter 2021). Building off this success, we developed a multi-step, recursive forecasting model to predict individual hospital admissions; this model incorporates the following data: (i) hospital-level COVID-19 admissions, (ii) statewide test positivity data, and (iii) aggregate measures of large-scale human mobility, contact patterns, and commuting volume.

Results

Incorporating large-scale, aggregate mobility data as exogenous variables in prediction models allows us to make hospital-specific COVID-19 admission forecasts 21 days ahead. We show this through highly accurate predictions of hospital admissions for five hospitals in Massachusetts during the first year of the COVID-19 pandemic.

Conclusions

The high predictive capability of the model was achieved by combining anonymized, aggregated mobile device data about users’ contact patterns, commuting volume, and mobility range with COVID hospitalizations and test-positivity data. Mobility-informed forecasting models can increase the lead-time of accurate predictions for individual hospitals, giving managers valuable time to strategize how best to allocate resources to manage forthcoming surges.
An angled-shape tip-based strategy for highly sensitive proteomic profiling of a low number of cells
Authors: Zhao Hongxian , Chen Yongle , Li Hang , Zhang Yangjun , Zhang Wanjun , Qin Weijie
Published: February 2023

An angled-shape tip-based strategy for highly sensitive proteomic profiling of a low number of cells.
Modification of multi-walled carbon nanotubes with platinum–osmium to develop stable catalysts for direct methanol fuel cells
Authors: Bekmezci Muhammed , Gules Gamze Nur , Bayat Ramazan , Sen Fatih
Published: February 2023

In the study, a new bimetallic catalyst was synthesized for methanol oxidation using multi-walled carbon nanotube (MWCNT)-supported platinum–osmium (PtOs) nanoparticles (PtOs@MWCNT NPs). Obtained NPs were used as catalysts in electrochemical analyzes.
Design and application of potentiometric sensors for the determination of mefenamic and phenylanthranilic acids
Authors: Kormosh Zholt , Khalavka Yuriy , Mittal Susheel K.
Published: February 2023

A mefenamate (phenylantranilate) potentiometric sensor based on an ion-pair of crystal violet as a membrane carrier was developed. The linear dynamic range was 8.4 × 10−5 to 1 × 10−1 M, the Nernstian slope was 42.3–87.6 mV pC−1 and the LOD was 8.4 × 10−5 (1.5 × 10−4) M.
Methylated guanosine and uridine modifications in S. cerevisiae mRNAs modulate translation elongation
Authors: Jones Joshua D. , Franco Monika K. , Smith Tyler J. , Snyder Laura R. , Anders Anna G. , Ruotolo Brandon T. , Kennedy Robert T. , Koutmou Kristin S.
Published: February 2023

Four new mRNA modifications were detected in S. cerevisiae by integrating an improved LC-MS/MS approach with an enhanced mRNA purification and validation process. Codons containing these modifications were further identified to impede translation.
Enhanced charge transport across molecule–nanoparticle–molecule sandwiches
Authors: Zhou P. , Qiao X. , Milan D. C. , Higgins S. J. , Vezzoli A. , Nichols R. J.
Published: February 2023

The electrical properties of large area molecular devices consisting of gold nanoparticles (GNPs) sandwiched between a double layer of alkanedithiol linkers have been examined.
A force field for bio-polymers in ionic liquids (BILFF) – part 2: cellulose in [EMIm][OAc]/water mixtures
Authors: Roos Eliane , Sebastiani Daniel , Brehm Martin
Published: February 2023

We present the extension of our all-atom force field BILFF to the bio-polymer cellulose in (aqueous) [EMIm][OAc]. The force field is focused on an accurate reproduction of the microstructure and hydrogen bonds with almost quantum chemical accuracy.
Evolution of vibrational bands upon gradual protonation/deprotonation of arsinic acid H2As(O)OH in media of different polarity
Authors: Tupikina Elena Yu. , Korostelev Vladislav O. , Krutin Danil V. , Tolstoy Peter M.
Published: February 2023

Arsinic acid H2As(O)OH can be strongly bound by various hydrogen bond donors and acceptors. The strength of this bond can be estimated using the distance between νAs=O and νAs–O bands in its IR spectra.
Indoor particulate matter (PM) from cooking in UK students' studio flats and associated intervention strategies: evaluation of cooking methods, PM concentrations and personal exposures using low-cost sensors
Authors: Tang Ruijie , Pfrang Christian
Published: February 2023

Domestic cooking is critical for release of particulate matter (PM) in indoor environments. This study tested low-cost sensors to assess PM from cooking in student studio flats for different cooking methods and to establish the impact of extractors.
Solid-state silicon anode with extremely high initial coulombic efficiency
Authors: Huang Yonglin , Shao Bowen , Wang Yan , Han Fudong
Published: February 2023

Silicon is considered an important anode material for solid-state batteries (SSBs) because of its unique properties in addressing key challenges associated with Li metal anodes such as dendrite formation and morphological instability.
Inorganic hydrogen-bonded SnO(OH)2as molecular springs boosted the piezocatalytic degradation of contaminants
Authors: Huang Xiao , Yan Wen , Sun Jingxiang , Hu Tao , Feng Jinxi , Huang Zhen , Tian Shuanghong , Xiong Ya
Published: February 2023

SnO(OH)2is the first highly active hydrogen-bonded inorganic piezocatalyst due to its rich hydrogen bonds and high valence band.
Acoustofluidics – changing paradigm in tissue engineering, therapeutics development, and biosensing
Authors: Rasouli Reza , Villegas Karina Martinez , Tabrizian Maryam
Published: February 2023

Acoustofluidic applications in biosciences; acoustic biosensing; acoustic trigger as a functional mechanical stimulus; cell separation and sorting; therapeutics development and delivery; cell patterning and assembly for tissue engineering.
Chelating silica nanoparticles for efficient antibiotic delivery and particle imaging in Gram-negative bacteria
Authors: Muguruza Asier R. , di Maio Alessandro , Hodges Nikolas J. , Blair Jessica M. A. , Pikramenou Zoe
Published: February 2023

Silica nanoparticles decorated with aminocarboxylate ligands are novel vehicles to deliver antibiotics which are otherwise not able to penetrate the bacteria membrane and can also include agents for tracking and imaging.
A bioinspired silica nanocomposite for enhanced multidrug-resistant bacteria treatment and wash-free imaging
Authors: Liu Xiaokun , Zhang Zhiying , Tomczak Nikodem , Yang Cong , Li Chengjun , Liu Rongrong , Yan Bing
Published: February 2023

A bioinspired silica nanocomposite demonstrates potent antibacterial activity and real-time imaging capability against multidrug-resistant bacteria.
The potential role of serum extracellular vesicle derived small RNAs in AML research as non-invasive biomarker
Authors: Li Lin , Mussack Veronika , Görgens André , Pepeldjiyska Elena , Hartz Anne Sophie , Aslan Hazal , Rackl Elias , Rank Andreas , Schmohl Jörg , El Andaloussi Samir , Pfaffl Michael W. , Schmetzer Helga
Published: February 2023

Extracellular vesicles (EV) are cell-derived vesicles released by all cells in health and disease.
Thiazolidine-2,4-dione framework containing spiropyrrolidine-oxindole and 1,2,3-triazole scaffold: synthesis, in vitro α-amylase inhibition and in silico studies
Authors: Duhan Meenakshi , Singh Rahul , Devi Meena , Sindhu Jayant , Kumar Parvin , Kumar Sudhir , Kataria Ramesh , Kumar Ashwani , Lal Sohan , Singh Devender
Published: February 2023

This study aimed to synthesize thiazolidine-2,4-dione hybrids followed by evaluating their α-amylase inhibition using in vitro and in silico approaches.
Involvement of halogen and polyaromatic substituents in chalcone derivatives as dye sensitizers in solar cell applications
Authors: Nizar Siti Nabilla Aliya Mohd , Rosli Mohd Mustaqim , Samsuri Siti Azrah Mohamad , Razak Ibrahim Abdul , Arshad Suhana
Published: February 2023

Pyrenyl chalcones act as sensitizers in DSSCs due to their co-planar structures, head-to-tail architecture, small Eg and appropriate HOMO–LUMO levels.
Synthesis of a half-sandwich complex of ruthenium(ii) with a nonsymmetric bis-nitrogen donor ligand: biological investigations
Authors: Yarahmadi Sana , Jokar Elham , Shamsi Zahra , Nahieh Dalia , Moosavi Mehrnoosh , Fereidoonnezhad Masood , Shahsavari Hamid R.
Published: February 2023

A biologically active Ru(ii) complex with a nitrogen donor ligand was prepared and characterized.
Rational design of 2D/2D ZnIn2S4/C3N4 heterojunction photocatalysts for enhanced photocatalytic H2 production
Authors: Guan Peng , Han Peigeng , Yang Bin , Yin Hang , Liu Jianyong , Yang Songqiu
Published: February 2023

The development of close contact two-dimensional (2D) heterojunction photocatalysts for hydrogen evolution performance possesses great significance.
Coupling of cerium oxide cyanamide with Fe–N–C for enhanced oxygen reduction reaction
Authors: Zhang Xu , Zhang Jingxian , Zeng Shi , Wang Haifan , Bai Yiling , Hou Huaming , Zhang Ke , Li Bin , Zhang Guangjin
Published: February 2023

Ce2O2CN2 was firstly used as a promoter to improve the catalytic activity and stability of Fe–N–C for the ORR.
Controllable dynamics of complex DNA nanostructures
Authors: Wang Wen , Shen Yue , Wei Bryan
Published: February 2023

In this minireview, we summarized the recent progress of controllable reconfigurations of complex DNA nanostructures induced by nucleic acid strands, environmental stimuli and enzymatic treatments.
A review of cost-effective black silicon fabrication techniques and applications
Authors: Soueiti Jimmy , Sarieddine Rim , Kadiri Hind , Alhussein Akram , Lerondel Gilles , Habchi Roland
Published: February 2023

Ever since the discovery of black silicon, scientists have been trying to come up with novel methods of utilizing this material in a variety of different industries due to its low reflectivity and excellent electronic and optoelectronic properties.
Modulation of electromagnetic wave absorption via porosity in Pechini-derived carbon guided by a random network model
Authors: Fang Yuan , Zhang Yue , Wang Wenjian , Wang Shuai , Hou Xingwang , Huang Yilin , Ye Weiping , Yang Rankun , Zhao Rui , Xue Weidong , Zhou Chenghua , Zhang Honghu , He Xiong
Published: February 2023

The mechanism of how porosity affects EM wave absorption was investigated with a quantitative random network model.
Correlative radioimaging and mass spectrometry imaging: a powerful combination to study14C-graphene oxidein vivobiodistribution
Authors: Cazier Hélène , Malgorn Carole , Georgin Dominique , Fresneau Nathalie , Beau Fabrice , Kostarelos Kostas , Bussy Cyrill , Campidelli Stéphane , Pinault Mathieu , Mayne-L'Hermite Martine , Taran Frédéric , Junot Christophe , Fenaille François , Sallustrau Antoine , Colsch Benoit
Published: February 2023

Correlative imaging approach based on the combination of radioimaging and MSI to study the14C-graphene oxide biodistributionin vivo.
A stretchable, environmentally stable, and mechanically robust nanocomposite polyurethane organohydrogel with anti-freezing, anti-dehydration, and electromagnetic shielding properties for strain sensors and magnetic actuators
Authors: Liu Yang , Zhang Zetian , Yang Xiaohan , Li Fufen , Liang Ze , Yong Yong , Dai Songbo , Li Zhengjun
Published: February 2023

A novel polyurethane organohydrogel with anti-freezing, anti-drying, and electromagnetic shielding abilities was used as a magnetic responsive switch and strain sensor.
Photostable organic solar cells based on non-fullerene acceptors with an aminated bathocuproine electron transport layer
Authors: Kim Yong Ryun , Lee Sanseong , Kim Juae , Oh Juhui , Kim Ju-Hyeon , Ki Taeyoon , Oh Chang-Mok , Hwang In-Wook , Suh Hongsuk , Lee Kwanghee , Kim Heejoo
Published: February 2023

Solution-processed bathocuproine (BCP) has been widely used in fullerene (FA)-based organic solar cells (OSCs) for decades as an electron transport layer (ETL).
Fe, Cu dual-metal single atom catalyst on commercial carbon black for efficient oxygen reduction reaction
Authors: Yang Hongzhou , Huang He , Wang Qing , Shang Lu , Zhang Tierui , Wang Shouguo
Published: February 2023

Fe, Cu dual metal single atom catalyst on commercial carbon black exhibited excellent oxygen reduction reaction performance.
CoSe2anchored vertical graphene/macroporous carbon nanofibers used as multifunctional interlayers for high-performance lithium–sulfur batteries
Authors: Mo Yangcheng , Yang Kaochun , Lin Junsheng , Liu Mengting , Ye Guanfei , Yu Jie
Published: February 2023

The rational design of VGMFs@CoSe2is a smart strategy to achieve high-performance Li–S batteries.
Synthetic engineering of a new biocatalyst encapsulating [NiFe]-hydrogenases for enhanced hydrogen production
Authors: Jiang Qiuyao , Li Tianpei , Yang Jing , Aitchison Catherine M. , Huang Jiafeng , Chen Yu , Huang Fang , Wang Qiang , Cooper Andrew I. , Liu Lu-Ning
Published: February 2023

By incorporating [NiFe]-hydrogenases into a proteinaceous carboxysome shell, we generate a novel biocatalyst that has improved production of clean hydrogen, oxygen tolerance, and thermostability, highlighting its great potential in biotechnological applications.
Europium(ii) complexes with substituted triethylenetetramine: new emitters to construct efficient deep blue organic light emitting diodes by spin coating
Authors: Qi Hao , Zhong Tianming , Huo Peihao , Zheng Jiayin , Zhao Zifeng , Yan Wenchao , Bian Zuqiang , Liu Zhiwei
Published: February 2023

We synthesized three efficient blue emitting Eu(ii) complexes with narrow full width at half maximums and fabricated the first deep blue OLEDs based on an Eu(ii) complex.
Stability enhancement and pronounced three-photon absorption in SrCl2-doped FAPbBr3nano crystals
Authors: Khanam Sarvani Jowhar , Banerjee Dipanjan , Soma Venugopal Rao , Murali Banavoth
Published: February 2023

Size-dependent perovskite nanocrystals (PNCs) have manifested tremendous improvement in nonlinear optical (NLO) studies owing to their remarkable optical and electrical properties.
Electrochemical detection of mephedrone using a graphene screen-printed electrode: a new sensitive and selective approach to identify synthetic cathinones in forensic analysis
Authors: Melo Larissa M. A. , Arantes Luciano C. , Schaffel Izabela F. , Aranha Lívia M. S. , Conceição Nathália S. , Lima Camila D. , Marinho Pablo A. , Ferreira Rafael Q. , dos Santos Wallans T. P.
Published: February 2023

We present the electrochemical detection of mephedrone in forensic samples using independent redox processes of synthetic cathinones on a graphene screen-printed electrode.
Integrating a fluorinated photoactive chromophore into metal–organic frameworks for selective trifluoroethylation of styrenes
Authors: Hou Leixin , Jing Xu , Huang Huilin , Duan Chunying
Published: February 2023

By virtue of light harvesting and proton transport of photoactive zinc–organic frameworks can be precisely regulated by the introduction of fluorine-containing moieties enabling them photocatalysts for photocatalytic selective trifluoroethylation.
Rapid deracemization through solvent cycling: proof-of-concept using a racemizable conglomerate clopidogrel precursor
Authors: van Dongen Sjoerd W. , Baglai Iaroslav , Leeman Michel , Kellogg Richard M. , Kaptein Bernard , Noorduin Willem L.
Published: February 2023

Using a Soxhlet-apparatus, we demonstrate that a conglomerate-forming clopidogrel precursor undergoing solution phase racemization can be deracemized through cyclic solvent removal and re-addition.
Two Janus Ga2STe monolayers and their electronic, optical, and photocatalytic properties
Authors: Shu Huabing
Published: February 2023

Janus SGa2Te monolayers have moderate direct gaps, suitable band edges for photocatalytic water splitting, and high light absorption coefficients for the visible light, suggesting their potential applications in optoelectronic and photocatalytic devices.
Does a halogen bond require positive potential on the acid and negative potential on the base?
Authors: Scheiner Steve
Published: February 2023

A halogen bond can form between two neutral molecules even if the positive σ-hole of the Lewis acid contacts a positive region of the base coincident with its π-bond or lone pair source of electron density.
Controlled alcohol oxidation reactions by supported non-noble metal nanoparticles on chitin-derived N-doped carbons
Authors: Polidoro Daniele , Ballesteros-Plata Daniel , Perosa Alvise , Rodríguez-Castellón Enrique , Rodríguez-Padrón Daily , Selva Maurizio
Published: February 2023

Non-noble metal nanoparticles supported on biomass-derived N-doped carbons as efficient and selective catalytic systems in alcohols oxidation reactions.
Three-dimensional ternary NixCuyZnz(CO3)(OH)2 electrodes for supercapacitors: electrochemical properties and applications
Authors: Lee Dong Hyun , Baek Juyoung , Kim Dong Hwan , Roh Jong Wook , Kim Jeongmin , Lee Damin
Published: February 2023

Schematic of the NiCu(CO3)(OH)2, NiZn(CO3)(OH)2, and NixCuyZnz(CO3)(OH)2 compounds prepared on a Ni foam substrate.
Vapochromism of indolenine-based heptamethine cyanine dye adsorbed on silica gel
Authors: Shibayama Mikiko , Uehashi Yuki , Ajioka Shouhei , Kubota Yasuhiro , Inuzuka Toshiyasu , Funabiki Kazumasa
Published: February 2023

Indolenine-based heptamethine cyanine dye adsorbed on silica gel shows vapochromism to amines or chlorinated solvents, leading to a color change.
A nonfullerene acceptor with π-conjugation extended end groups to achieve enhanced photovoltaic performance
Authors: Liu Chunyan , Wu Zhihui , Qiu Nailiang , Li Chenxi , Lu Yan
Published: February 2023

The π-conjugation extension on terminal unit enables high-efficiency photovoltaic performance, benefiting from the enhancement ofJscand FF.
A trifunctional Co0.85Se/NC collaborated electrocatalyst enables a self-powered energy system for uninterrupted H2 production
Authors: Tian Wen-Wen , Ying Yi-Dai , Ren Jin-Tao , Yuan Zhong-Yong
Published: February 2023

A self-powered energy system was constructed by integrating a silicon solar cell, zinc–air batteries and a water splitting device to achieve uninterrupted H2 generation, based on Co0.85Se/NC catalysts with promising OER, ORR and HER performance.
Injectable zwitterionic cryogels for accurate and sustained chemoimmunotherapy
Authors: Jing Zhang , Jie Lu , Sunxiang Qian , Haifeng Ni , Jie Feng
Published: February 2023

Zwitterionic cryogels as a drug-loading platform with extremely low immunogenicity and excellent biocompatibility were prepared for chemoimmunotherapy of cancer, showing obvious tumor inhibition.
Noise Exposure in Palestinian Workers Without a Diagnosis of Hearing Impairment: Relations to Speech-Perception-in-Noise Difficulties, Tinnitus, and Hyperacusis
Authors: Shehabi Adnan M. , Prendergast Garreth , Guest Hannah , Plack Christopher J.
Published: February 2023

Purpose:

Many workers in developing countries are exposed to unsafe occupational noise due to inadequate health and safety practices. We tested the hypotheses that occupational noise exposure and aging affect speech-perception-in-noise (SPiN) thresholds, self-reported hearing ability, tinnitus presence, and hyperacusis severity among Palestinian workers.

Method:

Palestinian workers (
N
= 251, aged 18–70 years) without diagnosed hearing or memory impairments completed online instruments including a noise exposure questionnaire; forward and backward digit span tests; hyperacusis questionnaire; the short-form Speech, Spatial and Qualities of Hearing Scale (SSQ12); the Tinnitus Handicap Inventory; and a digits-in-noise (DIN) test. Hypotheses were tested via multiple linear and logistic regression models, including age and occupational noise exposure as predictors, and with sex, recreational noise exposure, cognitive ability, and academic attainment as covariates. Familywise error rate was controlled across all 16 comparisons using the Bonferroni–Holm method. Exploratory analyses evaluated effects on tinnitus handicap. A comprehensive study protocol was preregistered.

Results:

Nonsignificant trends of poorer SPiN performance, poorer self-reported hearing ability, greater prevalence of tinnitus, greater tinnitus handicap, and greater severity of hyperacusis as a function of higher occupational noise exposure were observed. Greater hyperacusis severity was significantly predicted by higher occupational noise exposure. Aging was significantly associated with higher DIN thresholds and lower SSQ12 scores, but not with tinnitus presence, tinnitus handicap, or hyperacusis severity.

Conclusions:

Workers in Palestine may suffer from auditory effects of occupational noise and aging despite no formal diagnosis. These findings highlight the importance of occupational noise monitoring and hearing-related health and safety practices in developing countries.

Supplemental Material:

https://doi.org/10.23641/asha.22056701
Optimal feature‐algorithm combination research for EEG fatigue driving detection based on functional brain network
Authors: Zhou Yi , Zeng ChangQing , Mu ZhenDong
Published: February 2023

With the increasing number of motor vehicles globally, the casualties and property losses caused by traffic accidents are substantial worldwide. Traffic accidents caused by fatigue driving are also increasing year by year. In this article, the authors propose a functional brain network‐based driving fatigue detection method and seek to combine features and algorithms with optimal effect. First, a simulated driving experiment is established to obtain EEG signal data from multiple subjects in a long‐term monotonic cognitive task. Second, the correlation between each EEG signal channel is calculated using Pearson correlation coefficient to construct a functional brain network. Then, five functional brain network features (clustering coefficient, node degree, eccentricity, local efficiency, and characteristic path length) are extracted and combined to obtain a total of 26 features and eight machine learning algorithms (SVM, LR, DT, RF, KNN, LDA, ADB, GBM) are used as classifiers for fatigue detection respectively. Finally, the optimal combination of features and algorithms are obtained. The results show that the feature combination of node degree, local efficiency, and characteristic path length achieves the best classification accuracy of 92.92% in the logistic regression algorithm.
Performance analysis and control of a novel 7‐level active neutral point clamped (ANPC) topology
Authors: Zaid Mohammad , Sarwar Adil , Quayyoom Layeba , Tayyab Mohammad , Bakhsh Farhad Ilahi , Iqbal Atif , Ahmad Akbar
Published: February 2023

This paper introduces a novel 7‐level active neutral‐point clamped (ANPC) switched capacitor multilevel inverter (SCMLI) with voltage‐boosting capabilities. The proposed converter can produce seven levels and a voltage boosting of 1.5 times with a single dc source. For boosting the voltage, two self‐balanced switched capacitors and two dc link capacitors with active neutral point are used with nine switches. For controlling the output voltage, the level‐shifted modulation technique and modified nearest level control technique is used. The performance of the converter is evaluated with both modulation techniques. The operation of the proposed SCMLI and the design of capacitors for the proposed circuit is discussed in detail. The proposed topology can eliminate the leakage current and has reduced voltage stress across switches which makes it suitable for solar photovoltaic applications. The proposed converter is compared with some other recently introduced converters in terms of voltage gain, the number of components used, and the voltage stress across the switches. For verifying the performance of the proposed circuit, the experimental and simulation results are presented in the paper. The experimental results closely agree with the simulation and theoretical studies. The total harmonic distortion (THD) in the output voltage and efficiency is compared with both modulation techniques.
Continuum reverberation mapping of MCG 08-11-011
Authors: Fian C. , Chelouche D. , Kaspi S. , Sobrino Figaredo C. , Lewis T. , Catalan S.
Published: February 2023

Aims. We report the results from a photometric reverberation mapping campaign carried out with the C18 telescope at the Wise Observatory from 2019 to 2020, targeting the active galactic nucleus (AGN) MCG 08-11-011. The monitoring was conducted on a daily basis with specially designed narrow-band filters, spanning from optical to near-infrared wavelengths (∼4000 to 8000 Å) and avoiding prominent broad emission lines. We aim to measure inter-band continuum time lags, determine the size–wavelength relation, and estimate the host-subtracted AGN luminosity for this system.

Methods. We used the point-spread function photometry to extract the continuum light curves and measure the inter-band time lags using several methods, including the interpolated cross-correlation function, the z-transformed discrete correlation function, a von Neumann estimator, JAVELIN (in spectroscopic and photometric mode), MICA, and a multivariate correlation function.

Results. We find wavelength-dependent lags, τ(λ), up to ∼7 days between the multiband light curves of MCG 08-11-011. The observed lags are larger than predictions based on standard thin-disk theory by a factor of ∼3 − 7. We discern a significantly steeper (τ ∝ λ4.74) size-wavelength relation than the τ ∝ λ4/3 expected for a geometrically thin and optically thick accretion disk, which may result from the contribution of diffuse continuum emission to the flux. These results are similar to those found by previous continuum reverberation mapping campaigns.
Direct imaging discovery of a super-Jovian around the young Sun-like star AF Leporis
Authors: De Rosa Robert J. , Nielsen Eric L. , Wahhaj Zahed , Ruffio Jean-Baptiste , Kalas Paul G. , Peck Anne E. , Hirsch Lea A. , Roberson William
Published: February 2023

Context.Expanding the sample of directly imaged companions to nearby, young stars that are amenable to detailed astrometric and spectroscopic studies is critical for the continued development and validation of theories of their evolution and atmospheric processes.

Aims.The recent release of theGaiaastrometric catalog allows us to efficiently search for these elusive companions by targeting those stars that exhibit the astrometric reflex motion induced by an orbiting companion. The nearby (27 pc), young (24 Myr) star AF Leporis (AF Lep) was targeted because of its significant astrometric acceleration measured between the HIPPARCOSandGaiaastrometric catalogs, consistent with a wide-orbit planetary-mass companion detectable with high-contrast imaging.

Methods.We used the SPHERE instrument on the VLT to search for faint substellar companions in the immediate vicinity of AF Lep. We used observations of a nearby star interleaved with those of AF Lep to efficiently subtract the residual point spread function. This provided sensitivity to faint planetary-mass companions within 1″ (~30 au) of the star.

Results.We detected the companion AF Lep b at a separation of 339 mas (9 au) from the host star, at almost the exact location predicted by the astrometric acceleration, and within the inner edge of its unresolved debris disk. The measured K-band contrast and the age of the star yield a model-dependent mass of between 4 and 6MJup, consistent with the mass derived from an orbital fit to the absolute and relative astrometry of 4.3−1.2+2.9MJup. The near-infrared spectral energy distribution of the planet is consistent with an object at the L−T spectral type transition, but under-luminous with respect to field-gravity objects.

Conclusions.AF Lep b joins a growing number of substellar companions imaged around stars in the youngβPictoris moving group. With a mass of between 3 and 7MJup, it occupies a gap in this isochronal sequence between hotter, more massive companions, such as PZ Tel B andβPic b, and the cooler 51 Eri b, which is sufficiently cool for methane to form within its photosphere. Lying at the transition between these two classes of objects, AF Lep b will undoubtedly become a benchmark for studies of atmospheric composition and processes, as well as an anchor for models of the formation and evolution of substellar and planetary-mass companions.
Influence of sound spatial reproduction method on the detectability of reversing alarms in laboratory conditions
Authors: Valentin Olivier , Grandjean Pierre , Girin Clément , Gauthier Philippe-Aubert , Berry Alain , Parizet Étienne
Published: February 2023

This paper investigates the ability of binaural recording and reproduction to be used for measuring the detectability of reversing alarms in laboratory experiments. A complex and repeatible scenario was created using a wave-field synthesis system (WFS), and in-situ recordings in a lime mine. The reproduced sound field was further recorded with a dummy-head. Participants were asked to achieve a visual task (target tracking) while detecting two types of reversing alarms (tonal and broadband), mimicking an approaching vehicle. The experiment was conducted twice : at the center of a WFS array and in a sound-proof booth, using binaural recordings presented with headphones. Results showed that the detection times measured using binaural listening were significantly different from those measured in a fully immersive sound field reproduction. These differences were also greater with tonal sounds compared to broadband sounds. This study shows the limitations of the binaural technique to be used for such applications.
Constructions psychiques du paysage vécues au quotidien par les jeunes des quartiers populaires et les errants
Authors: Bordet Joëlle , Douville Olivier
Published: February 2023

Olivier Douville interviewe Joëlle Bordet à propos des constructions psychiques des paysages vécus au quotidien par les jeunes des quartiers populaires. La comparaison entre les jeunes des quartiers populaires urbains et ruraux montre que le paysage ne les laisse pas indifférent mais que leurs constructions psychiques à ce propos sont très différentes et ont pour conséquence des approches multiples du monde et des circulations possibles. La réflexion d’Olivier Douville à propos de jeunes en errance en Afrique Subsaharienne ouvre par la psychogéographie une perspective pour comprendre et accompagner tous les jeunes. À la fin de cet entretien, nous interrogeons le rapport des jeunes « à la terre » et comment cela influence ces rapports au paysage vécu au quotidien.
Éradication de la Psychologie Clinique et asservissement des psychologues
Authors: Raoult Patrick Ange
Published: February 2023

L’émergence du Dispositif MonPsy ne traduit pas en soi une préoccupation pour la souffrance psychique de la population mais une régulation économique des conséquences sociales des troubles psychiques. La promulgation de dispositifs rationalisés ambulatoires et coordonnés s’accompagne du démembrement des services publics. Le recours aux professionnels libéraux masque des effets de carence majeurs. Les psychologues se trouvent à une place qui les contraint à renoncer à ce qui fonde leur identité professionnelle. Rémunérations indigentes, prescriptions médicales, indications trop limitées, nombre de séances limitées, déficit de recrutement dans les services publics, sont les éléments de discussion. L’offensive massive par l’institution médicale sur le contrôle des psychothérapies s’inscrit dans une dynamique historique. Les psychologues sont conviés à la résistance ou à la servitude volontaire.
La possibilité d’un paysage chez l’agoraphobe
Authors: Fourment-Aptekman Marie-Claude
Published: February 2023

La construction d’un paysage est-elle compatible avec l’agoraphobie ? Cette question sera analysée à partir de la description de cas cliniques variés, puis par un retour sur les définitions multiples du paysage. C’est à partir de ces considérations que nous émettrons l’hypothèse que la construction d’un paysage est possible chez tout être humain, même agoraphobe, si certaines conditions paysagères sont réunies, et aussi, grâce au travail de mémoire, à la littérature, à la peinture, au cinéma, et aux différents arts qui nous permettent d’avoir nos paysages à la fois comme espace intérieur et comme ouverture sur le monde.
Was ist im Hier und Jetzt wichtig? Akzeptanz- und Commitment-Therapie (ACT) in der Psychoonkologie
Authors: Sauer Christina , Willig Katrin , Weißflog Gregor
Published: February 2023

Die Akzeptanz- und Commitment-Therapie (ACT) ist aufgrund ihrer Akzeptanz- und Werteorientierung ein vielversprechender Ansatz bei der Arbeit mit psychisch belasteten Krebspatient*innen. Der vorliegende Beitrag fokussiert auf die praktische Arbeit der ACT in der Psychoonkologie, die anhand der 6 Kernprozesse der ACT mit konkreten Fallbeispielen veranschaulicht wird.
Psychodynamische Psychotherapie bei existenzieller Belastung und schwerer Erkrankung
Authors: Vehling Sigrun , Walbaum Charlotte , Philipp Rebecca
Published: February 2023

Die Haushälterin Anna findet die schwerkranke Agnes erschüttert vor. Agnes ist verstört nach einer albtraumhaften Begegnung mit ihren scheinbar zu regungslosen Statuen erfrorenen Schwestern.
Agnes: „Kann mir nicht irgendjemand helfen?“

Anna: „Es ist nur ein Traum, Agnes.“

Agnes: „Nein, es ist kein Traum. Vielleicht ist es ein Traum für dich, aber nicht für mich.“
(Szene aus „Schreie und Flüstern“)
Fallbericht: Depression und somatische Beschwerden
Authors: Wesolowski Rosemarie , von Ploetz Klaus , Obendiek Jan-Hinrich , Hartmann Ralf
Published: February 2023

Ein aus Syrien geflüchteter Familienvater sucht über Jahre hinweg immer wieder Hilfe wegen somatischen Beschwerden (Schmerzen, Tinnitus, chronische Analfissur) und eines psychischen Beschwerdekomplexes aus vorwiegend depressiven Symptomen.
Chronobiologische Schlafforschung
Authors: Zulley Jürgen
Published: February 2023

Biologische Rhythmen über 24 Stunden betreffen praktisch alle Funktionen lebender Organismen. Diese Rhythmen sind nicht nur Folge des Tag-Nacht- oder Schlaf-Wach-Wechsels, sondern sie werden auch von „inneren Uhren“ erzeugt, sind mithin Ausdruck eines endogenen biologischen Rhythmus. Die im Beitrag beschriebenen Schlafstudien im Andechser Bunker weisen auf eine robuste Interaktion zwischen den biologischen Rhythmen und der Schlafregulation hin. Der zirkadiane Rhythmus (subjektiver und biologischer Tag) beträgt im Freilauf 25 Stunden. In unserem Alltag unter Einfluss des Tag-Nacht-Wechsels wird auch er vor allem durch den Einfluss des Tageslichts auf 24 Stunden synchronisiert. Helles Licht ist der wichtigste Zeitgeber, den die Menschen benötigen, um ihre biologischen Rhythmen „im Takt“ zu halten. Die biologischen Rhythmen geben bevorzugte Zeiträume für das Schlafen und das Wachen vor: Gegen 3 Uhr nachts findet sich ein biologisches Tief für viele Funktionen, gegen 17 Uhr herrscht verminderter Schlafdruck. Der Mittagsschlaf hat eine biologische Basis. Nächtliches kurzes Erwachen ist normal, gegen 3 Uhr sogar längeres Wachsein. Die spontane Schlafdauer beträgt 7–8 Stunden, sie setzt sich aber aus 2 kürzeren Schlafblöcken zusammen. Vor allem die Qualität des Tiefschlafs ist für den Erholungswert des Schlafes verantwortlich. Sein Auftreten hängt von der Dauer der vorhergehenden Wachzeit ab und ist unabhängig von der Schlafdauer.
Vaskulitis mimics
Authors: Schirmer Jan Henrik , Both Marcus , Müller OliverJ
Published: February 2023

Idiopathische Vaskulitiden sind seltene entzündliche Systemerkrankungen,
die nach der Chapel-Hill Konsensus-Nomenklatur nach der Größe
der prädominant betroffenen Gebiete von Blutgefäßen
(große, mittelgroße, kleine Gefäße und
Gefäße variabler Größe) eingeteilt werden.
Vaskulitis mimics sind Syndrome, die ein ähnliches klinisches Bild
hervorrufen oder leicht mit einer idiopathischen Vaskulitis verwechselt werden
und teils sogar ein Krankheitsbild, das klinisch und histologisch einer
Vaskulitis gleicht, auslösen können. Die Zahl der Vaskulitis
mimics ist groß, je nach betroffenem Gefäßgebiet kommen
hereditäre Erkrankungen des Bindegewebes, genetisch bedingte
Immundefekt- und Autoinflammationssyndrome, infektiöse Erkrankungen,
seltene entzündliche Systemerkrankungen, Tumorerkrankungen,
medikamenteninduzierte Syndrome und zahlreiche weitere infrage. In diesem Review
wird eine Auswahl klassischer Imitatoren von Vaskulitiden, orientiert an der
Größe der betroffenen Blutgefäße
präsentiert und Konstellationen, die typische
„Fallstricke“ in der klinischen Abklärung darstellen
können, diskutiert.
A Review of FXIa Inhibition as a Novel Target for Anticoagulation
Authors: Koulas Ioannis , Spyropoulos Alex C.
Published: February 2023

Limitations of vitamin K antagonists as chronic oral anticoagulant therapy have largely been supplanted by direct factor IIa and factor Xa inhibitor oral anticoagulants with similar efficacy but an overall better safety profile, lack of routine monitoring, and very limited drug–drug interactions compared with agents such as warfarin. However, an increased risk of bleeding remains even with these new-generation oral anticoagulants in fragile patient populations, in patients requiring dual or triple antithrombotic therapy, or high bleed risk surgeries. Epidemiologic data in patients with hereditary factor XI deficiency and preclinical studies support the notion that factor XIa inhibitors have the ability to be an effective but potentially safer alternative to existing anticoagulants, based on their ability to prevent thrombosis directly within the intrinsic pathway without affecting hemostatic mechanisms. As such, various types of factor XIa inhibitors have been studied in early phase clinical studies, including inhibitors of the biosynthesis of factor XIa with antisense oligonucleotides or direct inhibitors of factor XIa using small peptidomimetic molecules, monoclonal antibodies, aptamers, or natural inhibitors. In this review, we discuss how different types of factor XIa inhibitors work and present findings from recently published Phase II clinical trials across multiple indications, including stroke prevention in atrial fibrillation, dual pathway inhibition with concurrent antiplatelets post–myocardial infarction, and thromboprophylaxis of orthopaedic surgery patients. Finally, we refer to ongoing Phase III clinical trials of factor XIa inhibitors and their potential to provide definitive answers regarding their safety and efficacy in preventing thromboembolic events in specific patient groups.