bluuebunny/crossref_metadata_2025 huggingface dataset:
Concurrent use of drugs and potential drug interactions in HIV-infected patients in a tertiary healthcare facility in Turkey
Authors: Bilek Heval Can , Deveci Aydın , Şensoy Levent , Tanyel Esra
Published: March 2022

Purpose: To investigate the frequency of concurrent drug use and drug interactions in patients with human immunodeficiency virus (HIV) infection.

Methods: The medical records of HIV-infected patients followed up at Ondokuz Mayis University Hospital in the last six months were retrospectively reviewed to assess the antiretroviral therapy (ART) regimens used, the prescribed concurrent drugs, and their interactions

Results: The records of 268 patients were evaluated; of these, 43 (16 %) were women, and 225 (84 %) were men. The mean age of the patients was 43.8 ± 12.1 years. Concurrent drugs were prescribed to 210 (78.3 %) patients. Drug interactions were detected in 115 (42.9 %) patients. Of the 210 drug interactions detected, 168 (80 %) were potential interactions, 39 (18.6 %) were weak interactions, and 3 (1.4 %) were contraindicated. A statistically significant relationship was not observed in gender, age, and rate of concurrent drug prescription. Increased nephrotoxicity was the most common potential drug interaction. Non-steroidal anti-inflammatory drugs were the most commonly prescribed class of drugs along with ART.

Conclusion: Physicians treating HIV-infected patients should be conscious of, and careful about the concurrent use of drugs and their potential drug interactions.
HPTLC method development and validation for the determination of andrographolide in raw material and tablet containing ethyl acetate fraction of Andrographis paniculata
Authors: Ikayanti Retno , Hafid Achmad Fuad , Primaharinastiti Riesta , Widyawaruyanti Aty , Yuwono Mochammad
Published: March 2022

Purpose: To develop and validate a rapid, accurate, and selective High Performance Thin Layer Chromatography (HPTLC), for quantification of andrographolide in raw materials and tablets ethyl acetate fraction of Andrographis paniculata as antimalarial agent.

Methods: HPLC was conducted to determine the andrographolide concentration of ethanol extract and Camag linomat 5 in the stationary phase. HPLC measurements were conducted at a wavelength of 228 nm with a ratio of chloroform: methanol (90:10, v/v) in the mobile phase.

Results: The validated method was separated andrographolide from other component with good resolution, and obtained retention factor was 0.38 ± 0.03. The data for calibration plot showed good linear relationship, with R2 = 0.998 in the concentration range of 138.0 - 460.0 ng/spot. The limit of detection and quantification were 9.6 ng/spot and 28.8 ng/spot, respectively. The percentage recovery was between 98.0 and 100.5 %. Additionally, the relative standard deviation method was between 1.4 and 1.0 %

Conclusion: This method fulfills the validation requirements of selectivity, linearity, accuracy, and precision. Further, it can separate andrographolide from degradants. Thus, HPTLC method can be used to analyze the ethyl acetate fraction of ethanol extract of A. paniculata and its tablet products.
Community prevalence of carbapenemase-producing Gram-negative bacteria
Authors: Zhu Yihua , Cao Xinjian , Chu Fuying , Li Xinling
Published: March 2022

Purpose: To raise awareness of carbapenemase-producing organisms, identify “at-risk” patients when admitted in a medical healthcare facility, and to outline effective infection prevention and control measures in order to halt the entry and spread of these organisms.

Methods: A total of 1043 un-duplicated urine specimens of healthy volunteers who had no travel history or history of hospitalization were screened. The carbapenemase genotype of each imipenem-resistant strain was determined. Molecular typing and homology analysis of the main carbapenemase-producing strains were used to reveal the mode of transmission of resistance genes. Through transfer joint experiments, the potential risk of spread of carbapenemase genes was assessed.

Results: A total of 19 carbapenemase-producing strains from 1,043 non-duplicated healthy volunteers (1.82 %) were identified. The main carbapenemase-producing organism was E. coli (42.1 %, 8/19). The main carbapenemase genotype of E. coli was blaKPC-2 (7 strains). Results from multi-locus sequence typing (MLST) indicated that 7 E. coli isolates belonged to ST-10, ST-101, ST-131, ST-405, ST-410 and ST-1193 and ST-2562. Homologous cluster analysis revealed that the sequence types among the 7 E. coli were high in diversity. The blaKPC-2 gene was successfully transferred from these isolates to 10.22-14 via conjugation. All recipient cells showed marked decreases in carbapenem sensitivity to imipenem (p < 0.05)). The degrees of conjugation were 2.10±0.12 ×10-4, 1.96±0.14×10-4, 2.72±0.18 ×10-4, 3.15±0.20 × 10-4, 2.92±0.23 ×10-4, 3.50±0.20 ×10-4 and 4.12±0.24 ×10-4 in recipient cells of TC7.23-51, TC8.9-42, TC8.15-11, TC8.23-59-3, TC8.23-83, TC9.08-47 and TC10.13-15, respectively.

Conclusion: The findings demonstrate the pattern and features of carbapenemase-insensitive E. coli. The blaKPC-2 was the main community-prevalent gene of carbapenem-resistant E. coli. In view of increasing incidence of resistance to multi-drug therapy, surveillance of insensitivity to antibiotics is vital, especially urinary system infection due to carbapenem-insensitive E. coli.
A review of the anticancer properties of bee products and their molecular mechanisms: An overview on lung cancer
Authors: Alamri Abdulwahab
Published: March 2022

Lung cancer is one of the most common types of cancer in the world, and it represents a significant percentage of all diagnosed cancers. Despite better clinical outcomes associated with current drugs, lung cancer has a worse survival rate than any of the other commonly occurring malignancies. Evidence suggests that natural products offer promising potential for improving the current treatment approaches and/or developing novel treatment strategies. Bee products such as honey, propolis, and venom have been reported to exert anti-cancer effects on a variety of human cancer cell lines, thereby paving the way for a wide range of treatment possibilities. The current review focuses on the cytotoxic effects of bee bioactive compounds on all types of cancer, and the molecular pathways by which they might reduce tumor cell growth or trigger apoptosis of cancer cells, with particular reference to lung cancer. This strategy could potentially improve the efficacy of current remedies, reduce the doses of chemotherapy drugs, and decrease adverse effects of chemotherapy drugs. Furthermore, in vitro studies on anti-cancer properties of bee products are carefully reviewed. The results reveal that bee products have the potential to become effective treatment agents against many forms of cancer in the future.
Jatrorrhizine inhibits liver cancer cell growth by targeting the expressions of miR-221-3p and miR-15b-5p
Authors: Deng Bo , Wan Maolin
Published: March 2022

Purpose: To investigate the effect of jatrorrhizine on hepatic cancer cell proliferation and its mechanism of action.

Methods: Jatrorrhizine-mediated changes in cell viability were measured using (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay, while apoptosis induction was evaluated by flow cytometry. Transwell assay was used for the measurement of cell invasion, whereas cell migration was assessed by wound healing assay. The protein expression of Axin2 was determined with western blotting assay.

Results: Jatrorrhizine significantly (p < 0.049) suppressed the viability of HepG2 and HCCLM3 cells in the concentration range of 0.5 to 16.0 μM. Treatment of HepG2 and HCCLM3 cells with 4.0 μM jatrorrhizine markedly suppressed cell invasion, when compared to untreated cells (p < 0.0493). Jatrorrhizine significantly promoted the apoptosis of HepG2 and HCCLM3 cells at 48 h, relative to untreated cells, but 16.0 μM jatrorrhizine markedly suppressed the expressions of miR-221-3p and miR-15b-5p (p < 0.0493). Moreover, jatrorrhizine significantly up-regulated the protein expressions of Axin2 in HepG2 and HCCLM3 cells at 48 h (p < 0.0493).

Conclusion: Jatrorrhizine inhibits the proliferation, and suppressed the invasiveness and migration of HepG2 and HCCLM3 liver cancer cells, but increases their apoptosis. Moreover, it down-regulates the expressions of miR-221-3p and miR15b-5p and promotes Axin2 protein expression in HepG2 and HCCLM3 cells. Therefore, jatrorrhizine is a potential drug candidate for the treatment of liver cancer.
Evodiamine attenuates cadmium-induced nephrotoxicity through activation of Nrf2/HO-1 pathway
Authors: Song Zhichun , Wang Wei , Zhang Xiaoren , Yu Hongsheng , Qu Chunsheng , Dai Shu , Wang Xiaodong
Published: March 2022

Purpose: To investigate the protective role of evodiamine, a naturally occurring anti-inflammatory, antioxidant, and anti-apoptotic compound, against cadmium-induced cytotoxicity in proximal tubular cells (human kidney 2; HK-2).

Methods: HK-2 cells were treated with different concentrations of evodiamine (5, 20, 50 μM) for 2 h and then incubated with 40 μM cadmium chloride for another 24 h. Cell viability and apoptosis were evaluated using thiazolyl blue tetrazolium bromide (MTT) and flow cytometry, respectively. Oxidative stress was assayed by measuring the levels of malonaldehyde (MDA), superoxide dismutase (SOD), glutathione (GSH) and glutathione peroxidase (GSH-PX).

Results: Cadmium chloride treatment in HK-2 cells significantly reduced cell viability (p < 0.01) and increased apoptosis compared to the control. Evodiamine pretreatment attenuated the cadmium chloride-provoked decrease in cell viability and increase in apoptosis. Evodiamine also decreased expression of cleaved caspase-3 and cleaved caspase-9 in HK-2 cells. Cadmium chloride exposure provoked kidney injury, as evidenced by increased MDA levels and decreased SOD, GSH, and GSH-PX levels. Pretreatment with evodiamine ameliorated kidney injury, as shown by decreased MDA expression and increased SOD, GSH, and GSH-PX expression. Evodiamine exposure significantly enhanced protein expression of nuclear factor erythropoietin-2-related factor 2 (Nrf2) and heme oxygenase 1 (HO-1).

Conclusion: Evodiamine exerts an anti-apoptotic and anti-oxidative effect against cadmium chloride-induced nephrotoxicity via Nrf2/HO-1 pathway activation. These findings represent a potential therapeutic strategy for cadmium-provoked nephrotoxicity.
Gentiopicrin exerts anticancer effect on human colon cancer cells via caspase-dependent apoptosis, cell cycle arrest, and inhibition of cell migration and invasion
Authors: Zhang Zheng , Zhang Shaoyu , Yu Chenyuan
Published: March 2022

Purpose: To investigate the anticancer effect of gentiopicrin on human colon cancer (HT-295) cells, and its effects on caspase-mediated cellular apoptosis, cell cycle, cell migration and cell invasion.

Methods: MTT assay and clonogenic assay were used to study the effect of gentiopicrin on cell viability and cancer colony formation, respectively, while the apoptotic effects of gentiopicrin were determined using fluorescence microscopy and Western blotting. The effect of gentiopicrin on cell cycle was evaluated by flow cytometry, while Transwell assay was used to study its effects on cell migration and invasion.

Results: Gentiopicrin exerted potent and dose-dependent suppression of cell proliferation and colony formation, and produced pro-apoptotic effects on HT-295 colon cancer cells. Treatment of HT-295 cells with gentiopicrin resulted in up-regulated expressions of caspase-3, caspase-8, caspase-9 and Bax, while Bcl-2 expression was downregulated. Moreover, gentiopicrin dose-dependently induced cell cycle arrest in HT-295 cells at the G2/M phase, and inhibited cell migration and invasion.

Conclusion: Gentiopicrin exerts potent anticancer effects on human colon cancer cells via cell apoptosis and G2/M phase cell cycle arrest. In addition, it suppressed the migration and invasion of HT-295 cells. These findings provide useful basis for further in vivo research of gentiopicrin on colon cancer.
1 EDITORIAL
Authors: Rezende Vani Terezinha de
Published: March 2022

EditorialAS NOVAS DINÂMICAS DO SIMBOLO NAS PRÁTICAS DAS ESPIRITUALIDADES
MEMBANGUN APLIKASI SMS GATEWAY DENGAN MENGGUNAKAN APLIKASI ANDROID SMS GATEWAY DI UNIVERSITAS BANTEN JAYA
Authors: Gunawan Waliadi , Nuryani Ely , Utomo Joko Wahyu
Published: March 2022

Education institutions, especially universities, can not be separated from the activities that will surely related to academic information. Announcements made automatically by the system in one direction. When the internal information is collected, then the system will do the writing into database that is then processed to be sent to the corresponding number. So the message or information can be delivered quickly. A system used to simultaneously send SMS / Broadcast one them is the SMS Gateway. For now Academic School of Computer Science have yet to implement SMS Gateway application, and for that reason the authors decided to design and build a SMS Gateway Application that will be used as a tool that can help in the management of the notification to immediately. Of these problem led to the idea create web application SMS Gateway, SMS Gateway, and Android Application, which also can perform data management and messaging. The methodology used in the making of appliction is the waterfall methods. Web programming language is php. While android application using java. To view using Jquery, CSS, and Boostrap. MySql for Database. Tool and Editions used is XAMPP for windows 1.7.3, Photoshop, and Android Studio
PERANCANGAN VIRTUAL ASSISTANT ENTREPRENEURSHIP MENGGUNAKAN METODE SCRUM
Authors: Sudaryono Sudaryono , Lestari Nuke Puji , Gunawan Ketut
Published: March 2022

The birth of technology which until now is increasingly developing in all fields makes human work easier. Where services in the field of e-commerce and entrepreneurship can get information from a technology. However, there has been no development of a service information system for beginner entrepreneurs in obtaining information about entrepreneurship. So, the purpose of this research is the presence of a Virtual Assistant by building a chatbot to provide information to entrepreneurs through data that is already stored on the website system. In addition, experienced entrepreneurs can share information on the system. This design produces a chatbot prototype using AIML (Artificial Intelligence Markup Language) translated by ALICE (Artificial Linguistic Internet Computer Entity). This AIML function is so that the Chatbot is able to integrate the input results received in the form of text input so as to produce a conversation between the user and the program. The use of chatbots that are equipped with various information in the form of audio makes it easier for users to get information from a database system that is informed to prospective entrepreneurs. The Agile SDLC development method with the Scrum framework in this study helps system planning to run smoothly and is adjusted to the presence of artificial intelligence which makes entrepreneurs meet the information in starting the right business. The end result of this research, the system is able to motivate entrepreneurs, get information from an entrepreneur forum, and other tutorials about entrepreneurship.
PERANCANGAN APLIKASI SISTEM SERVICE MOTOR DI PT. MITRA SENDANG KEMAKMURAN
Authors: Effendi Rustam , Sutanto Sutanto
Published: March 2022

Mitra Sendang Kemakmuran Transaction data is still not properly and properly integrated, so it requires a long time in the process of recording transactions and a lack of orderly transaction data storage. Motorcycle Service System Application Design at PT. Mitra Sendang Kemakmuran was created using the Website and Mysql Database programming. The stages of making the system require designing a prototyping method and designing a database system with the concept of UML (Unified Modeling Language). This system can be used multiuser by utilizing technology. This system is designed to make it easier to service and sell spare parts as well as report service data and spare part sales to be faster and more precise.
SISTEM INFORMASI PENGELOLAAN PERBAIKAN DAN PENGGANTIAN SUKU CADANG MESIN INDUSTRI DEPARTEMEN STORE ROOM PT CHAROEN POKPHAND INDONESIA
Authors: Usman Andi Usri , Surahmat Ahmad , Reinaldo Anggi
Published: March 2022

In the current era of computerization, the computer is the tool used by each user, both individuals and institutions have to support the tasks and functions as well as obtain the required information in a way that easier and faster. Currently the department store room Charoen Pokphand Indonesia Company transaction process of repair and replacement of spare parts is still done manually, resulting data processing each transaction prone to error. The research outlined in this report aims to facilitate each employee Charoen Pokphand Indonesia Company, especially department Store Room in processing the data and monitor to be a good status. Thus the Store Room requires the design of information systems that can produce information quickly, reducing data errors occur, facilitate the search for the items required, so that all the transactions can be done easily. The methodology used for the development of this system is the Waterfall Model and storage of data using SQL Server 2005. With the design of Management Information Systems Repair and Replacement Parts Industrial Engineering Department Store Room is expected later in making applications run smoothly and can be applied in the company. After conducting research and analysis and discussion of the problem , there are some problems and obstacles that can be used as guidelines to improve the existing system so that in making this application program problems and obstacles can be overcome as well as possible to support the company's performance.
SISTEM INFORMASI PERSEDIAAN PUPUK PADA PT. GRESIK CIPTA SEJAHTERA
Authors: Romdoni Mochamad Yusuf , Fatullah Rizki , Ruhiawati Irma Yunita
Published: March 2022

The purpose of this study was to analyze the fertilizer supply system at PT.Gresik Cipta Sejahtera which is a system that helps process fertilizer inventory data so that it is expected to provide input on how to implement better data processing in the current era of information technology, this fertilizer supply system is carried out. with several stages of coordination through incoming letters of request to data collection based on recaptulation from the inventory by utilizing semi-computerized parts related, seeing that there are scattered data resulting in frequent inconsistencies of data so that data errors encourage checking that repeated so that a lot of time and energy is wasted, this is deemed ineffective and efficient. With the existence of computerization, it can make it easier for companies to monitor the warehouse section so that work in the warehouse section is more efficient and efficient, so that it can reduce obstacles that have occurred so far. The analysis method used to describe the inventory system at PT. Gresik Cipta Sejahtera uses the method of observation, interviews, and uses literature. The tools used to describe the system using DFD (Data Flow Diagram)
SISTEM INFORMASI AKADEMIK SISWA PADA SMPN 1 KOTA SERANG
Authors: Usman Andi Usri , Purnomo Afif
Published: March 2022

The development of internet technology rapidly, as one of information medium can certainly provide an ease in accessing information for an education institution. Before growing the internet technology, information process could not be worked properly, effectively, and efficiently. By the existence the Web-based information system of student academic monitoring at SMP 1 Kota Serang, it could provide convenience system for students or parents in monitoring students’ academic involved attendance information and student academic score. Monitoring is an activity that can be described as awareness about what would like to know, the highlevel monitoring is done in order to make the measurement of time that shows the movement or away from it. Monitoring will provide information on the status and tend to that measurement and evaluation are completed repeatedly from time to time, monitoring is generally carried out for specific purposes therefore the information provided by the school may be accepted well for students and parents. This web-based information system of student academic Monitoring at SMAP 1 Kota Serang was designed by using HTML, PHP, and MySQL as based of data. While in creating system design, the writer used the structured of database design method in diagram flow data (DFD). With applying student academic Monitoring, it can overcome the existing problems and ease in process of service that can be handled quickly and efficiently.
Socio-Economic Structure of Cattle Enterprises in Northeast Anatolia Region: An Example of İspir County of Erzurum Province
Authors: DİLER Abdulkerim , ÖZDEMİR Veysel Fatih , AYDIN Recep , YANAR Mete , KOÇYİĞİT Rıdvan , TOSUN Mesut
Published: March 2022

This study was carried out to reveal the current situation regarding the socio-economic characteristics of cattle enterprises in İspir county of Erzurum province. For this purpose, a face-to-face survey was conducted with 394 cattle farm owners determined using the random sampling method. The data obtained were interpreted using frequency analysis. The enterprises were mostly small-scale family types that had less than 20 (69.3%) animals. The number of cattle in the enterprises was classified as less than 11, 11-20, 21-30, 31-40, and more than 40 heads. Additionally, educational status of the owner of the enterprises were grouped as illiterate, literate, Primary School graduate, Secondary School graduate and High School graduate. The average age of the breeders was determined to be 55.2 years, with the majority between 50-70 years. The level of education of the breeders was low and the majority of them were primary school graduates (68.8%). More than half of the enterprise owners (58.4%) had more than 30 years of experience in cattle breeding. Apart from the owner, the number of people who cared for the animals was usually 2 people (43.7%) or 3 people (33.5%), and the person who cared for the animals was generally a family member. Only 27.9% of the enterprises were members of a union and 49.3% of the member enterprises preferred the Agricultural Credit Cooperative. As a result; the high average age of the population engaged in animal husbandry in the county makes it necessary to clear the way for young entrepreneurs with various supports and to prevent migration to the cities. In addition, carrying out various training and incentive activities to eliminate the disadvantages such as the low level of education of the breeders and membership of a union will make important contributions to the development of the Country’s livestock sector.
Supporting Open University students in prison: a case study
Authors: Huzar Geraldine , Kassem Hossam
Published: March 2022

The Open University (OU) has around 1800 students studying in prisons (Students in Secure Environments, 2019) with no internet access. They study offline with no access to the OU library’s online resources. This case study explores the student volunteer scheme introduced to help students in prison to indirectly access online library resources. It looks at how and why the service was set up, the experience of running the service and an initial evaluation. Due to the small number of students taking part in the pilot and Covid-19 interrupting the service, further research is needed to assess the full impact on students studying from prison. This will be the next stage of our work.
A systematic approach to designing English for very specific academic purposes materials tailored to a specific course in the main subject of a higher degree.
Authors: Greenwood Joe
Published: March 2022

This research looks at an area of materials design where little research has previously been conducted: English for very specific academic purposes (EVSAP). The research looks at related literature in EAP, ESP and ESAP, conducts a multi-stakeholder needs analysis, and incorporates the students into the materials design process itself. An analysis of the assignment brief and an interview with the unit lead of the chosen course in Digital Marketing were conducted, to identify aspects of academic writing and individual teaching activities that were beneficial to the course. The data gained from the interview were then used to create a questionnaire, which was distributed to students for completion. The data from the questionnaire were then processed into units of time; these units were then used to create the material’s structure. Discussion of how to construct a framework for EVSAP materials design is included, as well as the completed framework itself and a rationale for its format. Finally, the conclusion discusses the scope and limitation of the model, such as its application in other contexts or with different cohort sizes.
Student engagement and voice in higher education: students’ perceptions
Authors: Sun Xiaomei , Holt Deborah
Published: March 2022

There has been intense debate about student engagement and student voice in institutions of higher education in the past decade or so. Most of the discussion has been theoretical or based on a cause-and-effect research design. With the aim of gathering student perspectives on student voice and its related mechanisms, this study collected the voice of 13 students, the majority of whom were international students, from one UK university. Participants include undergraduate (n=1), postgraduate taught (n=7), and PhD (n=5) students who voluntarily agreed to have an online interview with the researcher, a PhD intern of the Student Voice team. Findings indicate that participants have an overall positive and supportive view of student voice mechanisms at this institution, although some understandings are not adequate or accurate. Participants’ attitudes towards some commonly used communication channels indicate that they prioritise an interactive and dynamic tool to initiate dialogue with the university. Suggestions are put forward for managerial strategies for a sustainable and inclusive student voice mechanism.
Supporting university staff to develop student writing: collaborative writing as a method of inquiry
Authors: Abegglen Sandra , Burns Tom , Sinfield Sandra
Published: March 2022

There is a feeling in the Learning Development community – and in academia more generally – that discipline staff see the academic writing of students as a problem better ‘fixed’ by others. However, staff at a writing workshop held within a learning and teaching conference revealed positions that were more nuanced, inflected, compassionate and ‘responsible’ than this. Writing collaboratively around the words produced by staff at our workshop, led to new insights into ways that staff could support student writing as an emergent practice. We decided to collect and share the many ways that discipline staff might be encouraged to harness writing in their own curriculum spaces: a staff guide on supporting writing and other forms of learning and assessment emerged. In this paper we discuss collaborative writing as a method of inquiry as we explore the contested terrain of academic writing, challenge the notion of ‘writing skills’, and model a more emergent form of exploratory writing.
Pengaruh Locus of Control, Perencanaan dean Literasi Keuangan terhadap Perilaku Keuangan UMKM
Authors: Fadilah Salma Juliana , Purwanto Eko
Published: March 2022

MSMEs are one of the drivers of the economy in Indonesia, in carrying out their business activities MSMEs are definitely influenced by the environment with the existence of self-control, financial planning and financial knowledge in those who carry out activities so that the business they run develops and creates good financial behavior. Behavioral finance is an attitude in which a person is able to consider and plan how to obtain a budget to meet business and individual needs. This study aims to analyze the effect of locus of control, financial planning, and financial literacy on financial behavior. The population in this study is MSMEs in Magetan Regency which are engaged in food and beverages. The sampling technique was done by purposive sampling. The sampling technique used the Slovin formula. The sample used in this study were 186 respondents. The data used in this study are primary data and secondary data, namely data from questionnaires from the answers of 186 respondents. The analysis technique in this study uses Partial Least Square (PLS). The results showed that locus of control, financial planning, and financial literacy had a significant positive effect on financial behavior.

Keywords: Locus of Control; Financial Planing; Financial Literacy; Financial Behavior
Pengaruh Electronic Word Of Mouth Dan Celebrity Endorser Terhadap Consumer Purchase Intention Smartphone Merek Vivo Melalui Brand Image Sebagai Variabel Mediasi (Studi Pada Konsumen Smartphone Vivo di Yogyakarta)
Authors: Udayana Ida Bagus Nyoman , Hutami Lusia Tria Hatmanti , Mayrenda Niken
Published: March 2022

Dalam penelitian ini bertujuan untuk mengetahui dampak Electronic Word Of Mouth dan Celebrity Endorser terhadap Consumer Purchase Intention Smartphone merek Vivo melalui Brand Image sebagai variabel Mediasi  (Studi pada konsumen smartphone Vivo di Yogyakarta). Penelitian ini bersifat kuantitatif dengan sampel 100 responden. Pengambilan sampel menggunakan metode purposive sampling. Pengumpulan data dengan cara menyebar kuesioner. Data analisis menggunakan SPSS versi 20. Kemudian data di uji menggunakan analisis regresi berganda. Hasil penelitian pada uji t menunjukkan bahwa variabel electronic word of mouth (X1) berpengaruh positif dan signifikan terhadap brand image (Z) memiliki nilai 0,001 < 0,05 dan celebrity endorser (X2) berpengaruh positif dan signifikan terhadap brand image (Z) memiliki nilai 0,000 < 0,05 Variabel brand image (Z) berpengaruh positif dan signifikan terhadap purchase intention (Y) memiliki nilai 0,018 < 0,05, kemudian variabel electronic word of mouth (X1) berpengaruh positif dan signifikan terhadap purchase intention (Y) memiliki nilai 0,001 < 0,05 dan celebrity endorser (X2) berpengaruh positif dan signifikan terhadap purchase intention (Y) memiliki nilai 0,000 < 0,05. Selain itu hasil penelitian juga menunjukkan bahwa brand image mampu berperan sebagai variabel mediasi pengaruh electronic word of mouth dan celebrity endorser terhadap purchase intention konsumen smartphone Vivo dengan menggunakan uji Sobel Test.
Analisis Pengaruh Sistem Kompensasi dan Disiplin Kerja terhadap Motivasi Kerja Kurir PT. Borwita Citra Prima Surabaya
Authors: Setiawan Muhammad Arif , Fauzi Akhmad , Swastika Ika Korika
Published: March 2022

The COVID-19 pandemic has a major impact on all business sectors, this can be evidenced by the soaring number of layoffs and cuts in labor wages in various companies. Ida Fauziyah (2021) stated that Indonesia's unemployment rate during the Covid-19 pandemic increased 4.9% to 7% or 9.7 million people. Therefore, business actors need to make effective and efficient business policies, including the Human Resource Department, which has the task of making employment policies within the company effectively and efficiently. The compensation system, work discipline, and work motivation are some of the urgent tasks of HRD during this COVID-19 pandemic. At PT. Borwita Citra Prima there are phenomena that indicate that the courier at the company is suspected of lacking good work motivation, from some of the data collected it is suspected that the source of the problem is the compensation system and work discipline of the courier in the company. On this basis, the researcher aims to obtain information about the effect of the compensation system and work discipline on the work motivation of couriers at PT. Borwita Citra Prima Surabaya. This study uses primary data obtained from respondents' answers (all couriers) in the company. To meet the research objectives, the researchers distributed a total of 60 questionnaires. Regarding the analysis, the researcher used the partial least square method with the help of PLS ​​software. From this research, two conclusions are obtained, the first is that the compensation system affects work motivation significantly (positively) with path coefficients of 0.270074, and the T-statistic value of 3.104459. The second is that work discipline affects work motivation significantly (positively) with path coefficients of 0.565998, and a T-statistic value of 7.515237.
Studi Literatur Skema Pembiayaan Lembaga Keuangan Mikro Syariah
Authors: Murizal Irvan , Soemitra Andri
Published: March 2022

Financing schemes carried out by Islamic microfinance institutions continue to face challenges with the development of these institutions. A unique financing scheme with a prohibition on interest-based financing. The literature study used in this study used data in the form of Scopus indexed articles. Data containing content related to financing schemes for Islamic financial institutions was selected with a total of 18 articles. Furthermore, the stages of research are carried out as described in the research methodology. The findings of this study describe two main financing schemes carried out by Islamic financial institutions, namely: The first scheme is Profit and Loss Sharing (PLS) with mudharabah, musyarakah, muzara'ah and muzaqat contracts. The second scheme is non-PLS, which includes murabahah, bai' salam, ijarah and qard al-hasanah. Other findings in this study describe Islamic MFI financing schemes in several countries such as: in Indonesia there are two financing principles in Islamic MFIs, namely equity financing using PLS mechanisms such as: mudharabah and musyarakah. The second principle is debt-based financing using a non-PLS mechanism. While in Bangladesh the Grameen Bank model was developed, but it is considered not to meet Islamic sharia because it still uses interest. Furthermore Kalanjiam financing scheme in India which is quite successful. Finally, in Latin America and Africa, the village bank model has been successfully implemented in accordance with sharia in Jabal al Hoss, Syria.

Keywords: LKMS, Financing, Literature Study
Az amerikai–dél-koreai szövetség dinamikája (2.
Authors: Mezei Tibor
Published: March 2022

Míg elemzésünk első részében a Koreai Köztársaság és az Egyesült Államok közötti kapcsolatoknak a dél-koreai demokratikus átmenettől (1987–88) kezdődő negyedszázadban történt alakulását tekintettük át, ebben a részben az elemzés tárgya a 2013-tól napjainkig tartó időszak. A fő kérdés továbbra is az, hogy Szöul önálló külpolitikai kezdeményezésre és középhatalmi ambícióinak kibontakozására való igénye miképpen egyeztethető össze az ország biztonságának sarokkövét jelentő amerikai szövetséggel. Ezzel összefüggésben mérleget vonunk és értékeljük Mun Dzsein elnök hamarosan véget érő elnöki periódusát a két ország közötti kapcsolatok vonatkozásában.
EFFECT OF CEPHALOSPORINS ON ( BIOFILM PRODUCTION AND PROTEASE ) ACTIVITIES BY SOME BACTERIA ISOLATED FROM OTITIS MEDIA
Authors: BAQER Batool Abd Al Ameer , ABBAS Maysoon Khaleefah
Published: March 2022

30 samples (swab) were collected from patients suffering from Otitis media. Swabs were implanted on the culture media blood agar and MacConkey agar to isolate the bacteria and to diagnose them using microscopic, culture and biochemical tests and confirmed by the Vitck-2 system. Of the total, 18 isolates were selected which belong to 8 (26.6%) Staphylococcus aureus, 5 (16.6%) Klebsiella pneumonia, and 4 (13.3%) Escherichia coli. All isolates were investigated for sensitivity to (18) antibiotics, six of them from the cephalosporins group The results showed that all isolates were 100% resistance to Cefotaxime, Ceftazidime, Cefixime, Ceftriaxone, Cefepime, Cefoxitin, Aztronam, Ampenicillin, while the isolates showed the lowest percentage of resistance to Imipenem (4.54) %, while all differences showed a clear difference in some of their resistance. Of the antagonists (Vancomycin, Erythromycin, Rifampin) with a percentage of (95.45, 27.27, 18.18)%, respectively. but for concentrations (4–16)µg/ml were ineffective for some of them. The (Minimal inhibitory concentrations ) MIC test indicated that it ranged between (4–32)µg/ml for Ceftriaxone and (16–32)µg/ml for Ceftazidime. All isolates were shown ability have (100%) activity to produce (Biofilm) was tested on the Congo red agar (CRA) medium, and ability to produce a protease enzyme by (72.22%) on Skim milk agar medium. The results showed a effect of inhibitory concentrations of Ceftriaxone on the activity of biofilm production and the protease enzyme, further the results of this study showed that the following concentrations (1024, 512, 256 and 128)µg/ml were lethal to isolates, while (32–64)µg/ml were inhibitory, Also, the molecular diagnosis shown results of Agarose - gel electrophoresis of both (normal case) S. aureus, E. coli and Kl. pneumonia and heal isolates observed the presence of chromosomal and plasmid DNA bands in the normal status but alone chromosomal DNA bands occur with the isolates deal in Ceftriaxone at levels of (32–128 )µg/ml. In the study of the effect of some Gram-negative bacteria by using IL-2 human. It can be used in the diagnosis of inflammation of the Otitis Media. Key words: Cephalosporins, Otitis media, Biofilm, protease, E. coli, Staphylococcus aureus, Klebsiella pneumonia.
EFFICIENT IMAGE ENCRYPTION SCHEMES BASED ON DEVELOPING AES ALGORITHM WITH FUZZY FUNCTION
Authors: KASHMAR Ali H. , HAZZAA Mohammed A. , SHIHAB Ammar I.
Published: March 2022

This paper suggests three image encryption schemes based on developing ofAdvance Encryption Standard (AES) algorithm with the employment of fuzzy function for diagnoses medical images. In the three proposed image encryption methods, the image is firstly scrambled using the: a) First Algorithm: start with applied AES algorithm then the result modulated with Fuzzy function; .b) Second Algorithm: start with modulated Fuzzy function then the result applied AES algorithm. c) Third Algorithm: star with combine between modulated Fuzzy function with each operations of AES algorithm. The usage of a fuzzy map as a pre-processing scrambling stage along with the AES algorithm gives the advantages of both the noise immunity from the fuzzy map and the security encryption from the AES algorithm. Furthermore, the Triangular Membership Function (TMF) parameters are utilized as additional extra keys that improve the security of the image encryption methods. The analysis results of the security as well as evaluate the efficiency of developed algorithms detect that the cipher text image acquired is the similar as the plaintext image and fuzzy set theory was suitable for apply as round function in the design of other block image ciphers. Moreover, the security properties, demonstrated that our designs were highly secure and robust against possible image cryptographic attacks. Finally, the NIST statistical test for randomness as well as performance comparison between proposed schemes with identical methods ciphers image revealed that the proposed algorithms were quite secure, efficient, and faster than the conventional block ciphers. Key words: Image encryption, Advance Encryption Standard (AES), Fuzzy set theory, Triangular Membership Function (TMF), Peak Signal-to-Noise Ratio (PSNR), National Institute of Standards and Technology (NIST).
COMPARISON BETWEEN CARDIAC ENZYMES IN PATIENTS WITH HYPOTHYROIDISM AND HYPERTHYROIDISM
Authors: HUSSAIN Zainab Khidhair , Ibrahim Bushra Rashid
Published: March 2022

Thyroid hormones modify each cardiovascular system component, it's essential for the function and development off the cardiac system. Thyroid hormones and the cardiac enzyme were measured in (120) Iraqi women aged (20-65) years in three groups: patients with hypothyroidism, hyperthyroidism, and control. Thyroid hormones (TSH, T3, and T4) were measure by ELISA by using a procedure of TOSOH,CHINA, also, cardiac enzymes were determined by biochemical assay of Biosystem company, Barcelona. The results showed the level of CK enzyme increasing non significantly (53.61) between groups in hyperthyroidism (G1), hypothyroidism(G2) and was (151.40 ±8.86uk) and (127.80 ±21.82uk) respectively compared with control was (G3) (100.60 ±18.80 uk),also the level of Troponin- I enzyme increasing non significantly (213.42) between groups was in(G1) (430.20 ±53.38) (Pg/UL), (G2) was (369.20 ±75.75) (Pg/UL) and (G3) (275.60 ±76.18).In comparison the study showed decreasing non significantly in cardiac enzymes as AST and ALT. It concluded that non-significant effect of thyroid hormones on the level of cardiac enzyme in both patients with hypothyroidism and hyperthyroidism. Key words: Hyperthyroidism, Cardiac Enzyme, Hypothyroidism, Hormones, Troponin I.
EFFECT OF IRAQI DESERT TRUFFLE AND SOME TYPE OF HONEY AGAINST SOME BACTERIA
Authors: MATTER Ikhlas Ramadan , ALMOLA Alaa Hussein , ALOMARI Aisha W.
Published: March 2022

The present study is interested in studying the effect of some natural nutrients on some types of bacteria , especially truffle and honey as food and nutritional value in our ancient parents. A water extract was prepared from the fruits of the black truffle and then studied the effect of this extract against Enterococcus faecalis, Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa, Staphylococcus aureus. The results showed that the water extract had a clear inhibitory effect on all the bacteria except P. aeruginosa, which showed resistance to the extract. The study also examined the effect of five types of honey in the crude (non-diluted) and diluted form 1: 1 (v: v) obtained from home honey bee, mountain honey, pine honey, grape leaves honey and German honey against the isolates under study. In the our study were showed that the types of honey have a broad and diversity of inhibition against microorganisms under study ,The raw Germany honey (non-diluted) showed high inhibition of P. aeruginosaas 25 mm inhibition zone .In comparison, the same type of honey showed 17 mm inhibition zone against S. aureus when diluted it ,while P.aeruginosa were showed resistance .The results showed that pine tree honey was the best honey used in the study. It showed a clear inhibitory effect on all the isolates used in the test in the crude and dilution form (1:1) without any resistance from any of the isolates. Key words: Truffle, Water extract, Antibacterial, Pathogenic Bacterial.
ANTIMICROBIAL SUSCEPTIBILITY PATTERN AND THE ANTAGONISTIC EFFECT OF LACTOBACILLUS IN FIGHTING SHIGELLA SPP. ISOLATED FROM DIARRHEIC CHILDREN
Authors: AlBERMANI Oruba K. , KHADHIM Isrra Adnan Auda , SAHI Nebras Mohammed
Published: March 2022

Background: Shigella is an major source of bacterial gastroenteritis in lack of health awareness in society. The handling of shigellos is mostly requires antibiotics. The using of probiotic of Lactic acid bacteria possess the counter effect against many dangerous bacterial pathogens which associated with gastroenteritis like Shigella spp. Aim: the purpose of this study to estimate the influence of lactic bacteria of the genus Lactobacillus on the population Shigella as a main pathogen involved in gastroenteritis in children. Patients and methods: A total of 50 stool specimens were collected during the period September2019 to January 2020 from diarrheic children patients age range(1-3)years. Standard bacteriological methods were used to isolate, identify, and determine the antimicrobial susceptibility pattern of Shigellaisolates, and we used fresh culture of Lactobacillus 24 h (previously isolated as member of fecal microbiota from healthy person and identified by molecular assay). Then we done centrifugation to obtain supernatant which have test bioactive materials like bacteriocin. These bacteriocin materials subjected to own antibacterial activity against other bacterial pathogen like Shigella spp. By using agar diffusion method . Results: All the 14 Shigella spp. isolates show 100% resistance to nalidixic acid,. cotrimoxazole , and High resistance to ciprofloxacin (85%), and moderate resistant of ampicillin (64%). In agar- well diffusion method indicated the high antagonistic activity of the strains of Lactobacillus 2, 3, and 4 isolated from health GI tract against all Shigella spp., as a result of their activity the total elimination of Shigella within 24 h was observed. conclusion: the Shigella spp. Strains exhibited antibiotic resistant against more one type of antiobiotic The lactobacilii strains tested during this study showed strong antimicrobial activity against Shigella spp. Key words: Shigellos is, Lactobacillus, 16S Rrna.
Development and Quality Assessment of Probiotic Shrikhand Incorporated with Kiwi (Actinidia Deliciosa) Fruit Pulp
Authors: Ms. Bhavika Pralhad Dhanmeher  , Prof. Hanmant Bodhankar  , Prof. Ashish Todkar
Published: March 2022

Milk preservation by fermentation is an old age technique. Shrikhand is a semi solid, sweetish-sour, whole milk product, prepared from lactic fermented curd. It is nutritionally dense fermented milk product. Its nutritional and therapeutic value can further be enhanced by incorporating filled milk, fruit pulp or probiotics. They are highly nutritious product because of increased vitamin content as selective cultures are being used in preparation of curd. The basic aim of the study was “Development of Probiotic Shrikhand incorporated with kiwi pulp.” Shrikhand was prepared using as per the standard method using 2% activated culture of L.helvetics and S.thermophilus and different levels of kiwi pulp 10%(T1), 20%(T2), 30%(T3), while Control sample T0 was prepared without addition of kiwi pulp and stored for 30 days at 4ºc. Proximate composition of raw materials, Sensory attributes, Physico-chemical constituents and Microbiological analysis was analysed from prepared product and data collected from that were tabulated. Storage study of probiotic shrikhand (absence of coliforms) had good storage stability during 30 days of storage at refrigeration temperature (4ºc). T1 (10%) supplementation of kiwi pulp to shrikhand was much preferred. Probiotic shrikhand could thus serve as good carrier of probiotic bacteria to improve our gut health. It also help in individuals having lactose intolerant. Hence, Shrikhand can provide therapeutic benefits to the consumer with longer shelf life.