bluuebunny/crossref_metadata_2025 huggingface dataset:
PRACTICAL APPLICATIONS OF TEACHING CRITICAL THINKING SKILLS IN AN ONLINE CLASS IN THE CONTEXT OF INDIA (SPECIAL REFERENCE TO RURAL AREAS)
Authors: Dr Poonam Kimta Chauhan
Published: October 2024

This study aims to investigate the level of critical thinking skills among students in rural areas of India and assess the effectiveness of online platforms in promoting these skills. A mixed-method approach combining qualitative and quantitative methods was utilized, including surveys, interviews, and observations. The sample consisted of 100 teachers and 100 students from various rural schools in India. Convenience sampling was employed to collect data, and a self-administered online questionnaire was distributed to participants. Data analysis involved descriptive statistics, Cronbach’s alpha reliability test, and various statistical tools such as Correlation and regression Analysis in SPSS. The findings revealed that the level of critical thinking skills among students in rural areas of India was moderately influenced by the effectiveness of online platforms. The study highlights the importance of integrating online platforms to enhance critical thinking skills in rural educational settings.
COMPARATIVE ANALYSIS OF THE ANTIMICROBIAL EFFICACY OF AYURVEDIC SEEDS IN WASTEWATER FILTRATION
Authors: Tanish Veernapalli  , Saketh Kollipara  , Tara Pratapa
Published: October 2024

Waterborne diseases such as Hepatovirus, Vibrio Cholera, Shigella, Salmonella, Campylobacter, and Escherichia coli pose significant public and individual health challenges in underdeveloped areas lacking access to safe and clean drinking water, as mentioned in the UN Sutainable Develepment Goal Number 6, which highlights the need for sustainable and cheap water purification methods. This experiment tested the antimicrobial properties of the following ayurvedic  (i) Strychnos Potatorum, (ii)Moringa Oleifera,(iii) Salvia hispanica,(IV) Foeniculum vulgare Mill, by taking stable concentrations of each seed extract and testing them against dirty water samples collected from polluted water sources. Water samples have been mixed with definite concentrations of extract, spread under agar, and then incubated for 24 hours to identify bacterial inhibition zones. After 24 hours of incubation, a Manual colony counter LMCC-A11 was used to identify major countable colonies. The sample of Strynchnos Potatorum showed the greatest bacterial inhibition, followed by Foeniculum Vulgare Mill, Slavia Hispanica, and Moringa Oleifera. Compared to dirty water, the seeds inhibited what was nearly 500-700 colonies of bacteria that could have been present in the samples.With the results above, seeds, ayurveda sample Strynchnos Potatorum, showed the most antimicrobial activity against the various bacteria and harmful compositions present in dirty water, representing its strong potential in being able to filter microbes in water to greater extents. This investigation addresses the importance of sustainable and cheaper methods of water filtration by diving into the antimicrobial aspects of various plant extracts against contaminated water, highlighting its replaceability with traditional filtration methods
GROUNDWATER QUALITY ANALYSIS AND ITS IMPACT ON AGRICULTURAL PRODUCTIVITY: A CASE STUDY
Authors: P. M. Ghadge  , D. B. Panaskar
Published: October 2024

Ground water quality of twenty villages selected were from Karad taluka in Satara district was assessed during pre and post monsoon in the year 2017. The ground water samples were collected from bore wells and open wells, and their quality parameters were assessed for following attributes such as pH values ranges from   in pre-monsoon and   in post-monsoon, EC values in pre-monsoon and in post-monsoon of the samples. Most of the samples were found to be magnesium dominating in the pre-monsoon and in post-monsoon Ca2+ exceeds the Mg content in most of the water samples. The observation for post monsoon can result in Mg2+ toxicity which will be exhibited due to the continuous use this of water to crops.
Cations and anions concentration varies in post-monsoon is Ca-8.251meq/L, Mg2+-11.05 meq/L, CO3-5.275 meq/L, HCO3-10.85, K-21.781, Na2+-8.73 respectively while in pre-monsoon Ca2+-9.625 meq/L, Mg2+-10.248 meq/L, CO3- 2.672meq/L, HCO3-8.762meq/L, K-13.092meq/L, Na-14.382meq/L respectively.
Some parameters are analyzed statistically such as Mg Hazard, RSC, SSP, KR, RSBC, PI etc.to determine better efficiency of observations. RSC values varied from 1.1-25.2 meq/L in pre-monsoon and 80 % samples are under unsafe while 5 % are in moderate range, 15 % are safe in post-monsoon 1.1- 28.2 meq/L and 85 % are in unsafe, 5 % in moderate,10 % in safe mode, 5 % moderate, 10 % in safe mode for irrigation. SSP values in samples varied from 6.222-79.452 % (post-monsoon) to 6.671-72.84 % (Pre-monsoon); 35 % samples were good while 65 % samples were found unsuitable in pre-monsoon samples and 50 % good while 50 % unsafe in post-monsoon samples respectively.
KR values in pre-monsoon observed 0.0303-6.22 meq/L while in post-monsoon it was 0.143 to 72.631 meq/L; according to Kelley’s ratio 75 % in suitable, 5 % marginal and 20 % unsuitable in pre monsoon while 65 % suitable, 5 % marginal, 30 % unsuitable for agriculture. RSBC values are observed in pre-monsoon 1.0-8.65 while in post-monsoon 0.f3-8.65
Permeability Index (PI) also analyzed it was observed in pre-monsoon 14.208-95.661 % in post-monsoon 15.327-71.549 was observed samples are under the categories of 15 % suitable, 55 % good (class II), 30 % unsuitable (class III) in pre-monsoon and 75 % good (class II), 25 % unsuitable (class III). The most of the analyzed water samples are under alkaline category; alkaline water should be managed carefully to avoid negative impacts on crops as well as on soil.
Geochemistry and mineralogy of the shale-hosted vanadium Van Property deposit, Mackenzie Mountains, Northwest Territories
Authors: Brueckner Stefanie M. , Green Turner , Reynolds Merilie A. , Gregory Daniel , Silva Ricardo
Published: October 2024

Shales and mudstones are fine-grained rocks formed in sedimentary basins throughout Earth’s history. These lithologies are increasingly important targets for mineral deposit exploration since they can have economic resources of critical minerals including vanadium (V), an essential component of redox-flux batteries in solar cells. However, many Paleozoic shale-hosted V deposits are metamorphosed and deformed. This commonly obscures primary features including V-bearing host phases and the original composition of organic material.

In this study, we present geochemical and mineralogical data from the Paleozoic Van Property deposit, Northwest Territories, Canada, to show that V can be released from organic matter during metamorphism and incorporated in clay phases such as illite. The siliceous argillites at the Van Property hosts up to 0.69% V2O5 and were metamorphosed to (sub-)greenschist facies. Their mineralogy is dominated by quartz with minor graphite, illite, muscovite, pyrite, sphalerite, rutile, and carbonates. Although, some illite (i.e., high-V illite) can have up to 13 wt% V2O3 and rutile can have up to 4.4 wt% V2O3, mass balance calculations are insufficient to explain V enrichment at the Van Property utilizing only illite and rutile. The third V host is inferred to be carbonaceous matter in which V accumulated syn-deposition on the seafloor. Subsequent metamorphism led to the demetallation of V-bearing geoporphyrins and the release of vanadyl ions (VO2+), some of which were then incorporated into high-V illite and rutile. This process of V enrichment highlights the role of organic matter in scavenging V from superficial reservoirs and the importance of metamorphism on subsequent V release and its incorporation into inorganic phases. The geochemistry of siliceous, V-rich argillites at the Van Property is also compared to other V-enriched shale and mudstone deposits, highlighting the diversity of shale-hosted V deposits, and emphasizing the need for further research to close the knowledge gaps related to variations in composition, mineralogy and V enrichment processes.
Nonequilibrium probability currents in optically-driven colloidal suspensions
Authors: Thapa Samudrajit , Zaretzky Daniel , Vatash Ron , Gradziuk Grzegorz , Broedersz Chase , Shokef Yair , Roichman Yael
Published: October 2024

In the absence of directional motion it is often hard to recognize athermal fluctuations. Probability currents provide such a measure in terms of the rate at which they enclose area in the reduced phase space. We measure this area enclosing rate for trapped colloidal particles, where only one particle is driven. By combining experiment, theory, and simulation, we single out the effect of the different time scales in the system on the measured probability currents. In this controlled experimental setup, particles interact hydrodynamically. These interactions lead to a strong spatial dependence of the probability currents and to a local influence of athermal agitation. In a multiple-particle system, we show that even when the driving acts only on one particle, probability currents occur between other, non-driven particles. This may have significant implications for the interpretation of fluctuations in biological systems containing elastic networks in addition to a suspending fluid.
Relationship Between Self-efficacy and Attention using QEEG with Students from IUE
Authors: Lopez Rios Edgar
Published: October 2024

Self-efficacy is related to the judgments and beliefs that a person has about him or her own capability to achieve goals, in which she or he also needs to be able of planning, organizing, and executing tasks to achieve that milestone. In this study, we are investigating if attention has a relevant role in self-efficacy.
The participants were students at Institución Universitaria de Envigado (N = 25), aged between 18 and 40 years old. They filled out the informed consent, the General Self-Efficacy Scale (GSS), Digits and Symbols (DS), the Brief Attention Test (BTA), and the Theta-Beta ratio (TBR) using EEG at points C3-C4 of the cerebral cortex.
The results were as follows: mean GSS, 31.56 (SD=4.5) (max. 40 points); mean DS direct score, 45.16 (SD=8.6) (max. 120 points); mean total BTA, 9.4 (SD = 3.31) (max. 20 points); mean TBR C3 eyes open, 5.5 (SD = 1.7); TBR C4 eyes open, 5.2 (SD = 2). A negative correlation was found between the TBR C4 eyes open and the result of the Digits and Symbols DS test, which was statistically significant, using Spearman correlation, (-.529); however, there was no significant correlation between GSS self-efficacy and the three measures of attention (DS, BTA, QEEG)
The conclusion of this study is that there is no clear statistically significant relationship between high self-efficacy and a high level of attention. However, a significant negative correlation was found between the DS test and the QEEG measures, which indicates that the neurophysiological technique of attentional measurement is related to the psychometric measurement.
SynchroLINNce: toolbox for Neural Synchronization and Desynchronization Assessment in Epilepsy Animal Models
Authors: M. A. F. Rodrigues Sofia , R. Cota Vinícius
Published: October 2024

Epilepsy is a worldwide public health issue, given its biological, social, and economic impacts. Considering several open questions about synchronization and desynchronization mechanisms underlying epileptic phenomena, the development of algorithms and computational toolboxes for such analysis is highly relevant to their research. Moreover, given the recent developments of neurotechnology for epilepsy, it is essential to understand that proposals like computational tools may provide consistent data for closed-loop control systems, necessary in neuromodulation treatment alternatives, and for real-time monitoring systems to predict the occurrence of epileptic seizures. In the present work, SynchroLINNce, a freely distributable MATLAB toolbox designed to be used by epilepsy neuroscientists, including software-untrained), is proposed. Among its features, several functionalities such as recording visualization, digital filtering, and correlation analysis, as well as more specific methodologies, such as mechanisms for the automatic detection of epileptiform spikes, morphology analysis of these spikes, and their coincidence between channels are presented.
Redes sociales y aprendizaje móvil en Educación Física: Creación colaborativa de principios de diseño
Authors: Montiel-Ruiz Francisco José , Calderón Antonio , Sánchez-Vera María del Mar , Solano-Fernández Isabel María
Published: October 2024

La Educación Física debe centrarse en el desarrollo de los dominios físico, cognitivo, social y afectivo del estudiante, sirviéndose, entre otros, de las potencialidades de las metodologías activas y el uso de recursos tecnológicos. Para ello, deben existir principios de diseño que guíen las estrategias pedagógico-digitales a implementar por parte de los docentes del área. El objetivo de este estudio es la creación de estos principios mediante la colaboración de profesorado y alumnado a través de un proyecto de intervención colaborativo que tuvo lugar en un contexto real de aula. El método de investigación se corresponde con el de Investigación Basada en Diseño, adecuado a la integración de recursos digitales y a la colaboración con diez docentes participantes en un proceso iterativo de tres años de duración para el diseño, implementación y evaluación de dicha intervención educativa. El profesorado participante imparte docencia a 17 grupos de Educación Secundaria de los niveles de 4º ESO y 1º de Bachillerato (un total de 372 estudiantes, siendo 189 chicas y 184 chicos). Los resultados de este estudio muestran una serie de principios de diseño para implementar estrategias pedagógico-digitales relacionadas con entornos virtuales de enseñanza-aprendizaje específicos para Educación Física.
¿Cómo influye el nivel socioeconómico en la autopercepción de la competencia digital del alumnado de educación secundaria en España?
Authors: Niño-Cortés Luz Mayra , Grimalt-Álvaro Carme , Sanabria Cárdenas Irma Zoraida , Usart Rodríguez Mireia
Published: October 2024

En el contexto de la educación secundaria y en una sociedad digitalizada, resulta crucial investigar la brecha digital en educación. Esta brecha, entendida desde las desigualdades sociales en el desarrollo de competencias digitales, implica indagar el desarrollo de la Competencia Digital (CD) y los factores que la determinan. Este estudio analiza la influencia de la variable socioeconómica en la autopercepción de CD en el alumnado de la Educación Secundaria en España. La investigación es cuantitativa, con diseño de encuesta. La muestra está representada por 2411 alumnos/as de la Educación Secundaria Obligatoria (ESO) y bachillerato. Se utilizó el cuestionario Digitalis-ESO y se realizó un análisis comparativo de la CD y sus indicadores, mediante la prueba de Kruskal-Wallis. Los resultados revelan que a medida que aumenta el nivel socioeconómico y ciclo de estudio, la CD también aumenta, sólo en la ESO y en el alumnado de nivel socioeconómico bajo y medio. Esto manifiesta la vulnerabilidad del alumnado de bajo nivel socioeconómico, en particular, en la primera etapa de la ESO y mayor medida en los aspectos académicos de la CD. Y señala una brecha digital en la educación secundaria, que posiciona al alumnado de entornos socioeconómicos desfavorecidos en desventaja para adquirir CD.
An experimental analysis of the relationship between the evaluations of artificial intelligence and pre-service teachers
Authors: Galindo-Domínguez Héctor , Delgado Nahia , Sainz de la Maza Martín , Expósito Ernesto
Published: October 2024

One of the potential benefits of AI is that it may allow optimizing teachers' tasks, enabling them to be more efficient in their work. This study aimed to analyze potential differences between the evaluations given by pre-service teachers and the evaluations given by different generative AIs. A total of 507 pre-service teachers participated, who were provided with a rubric to evaluate 12 texts of different types and qualities. The results showed how the performance of generative AIs in evaluating written tasks replicated the functioning of pre-service teachers quite accurately, with ChatGPT being the AI that best replicated the behavior of pre-service teachers, with an accuracy close to 70% of the evaluation provided by humans. Similarly, there were minimal differences in the evaluations given by pre-service teachers based on their gender and academic year. Likewise, generative AI overestimated scores provided for texts. However, this overestimation decreased as the performance of pre-service teachers improved. Thus, assessments provided by high-performing pre-service teachers were more aligned with those provided by generative AI compared to students with lower performance. These results are useful as they highlight how generative AI could be an aid tool guiding the pedagogical knowledge of pre-service teachers in digital assessment tasks.
Behavior of Halal Cosmetic Product Purchase Decision In Generation Z
Authors: Afendi Arif , Mashilal Mashilal , Ghofur Abdul , Izza Nabilla Baitul
Published: October 2024

One of the halal lifestyles that continues to increase in Indonesia is the use of halal cosmetic products. The purpose of this study was to examine the effect of religiosity and country of origin on purchase decisions for halal cosmetic products through the variable halal awareness as an intervening variable. Analysis of the model used is Partial Least Square-Structural Equation Modeling (PLS-SEM). The data in this study are primary data with 273 generation Z respondents in Central Java Province who use halal cosmetic products. The sampling technique was carried out using purposive sampling method. The results showed that there was a positive and significant influence between religiosity and country of origin on purchase decisions for halal cosmetic products. Furthermore, halal awareness is able to mediate the relationship between religiosity and country of origin on the decision to purchase halal cosmetic products. Policy implications that can be applied by stakeholders include increasing halal education policies, strengthening halal certification on imported cosmetic products, facilitating halal certification on MSME products, and helping to promote local halal cosmetic products.
Theory of Planned Behavior on Green Marketing Influence to Green Purchase Decision
Authors: Hidayat Taufiq , Sananta Dinda Putri
Published: October 2024

This study investigates the correlation between green marketing and consumer buying behaviour, with a specific focus on Garnier Men consumers in Semarang. A total of 162 participants, who were well-acquainted with Garnier Men products and had knowledge of green marketing, were chosen using purposive sampling. The study utilises Structural Equation Modelling (SEM) with AMOS 24.0 software to analyse the data. The key findings suggest that green marketing has a considerable impact on consumer attitudes and subjective norms, but it does not have a direct effect on green purchase decisions. Attitudes, subjective standards, and perceived behavioural control were identified as key factors influencing green purchase behaviour. The report emphasises the necessity for organisations to prioritise these variables instead of exclusively depending on green marketing methods. Furthermore, the study emphasises the significance of providing concise and easily understandable information regarding the environmental effects of products. The research, however perceptive, is constrained to a particular demographic and product line, indicating that future research should encompass a wider array of age groups, professional backgrounds, and product categories in order to improve its generalizability.
Online Language Education: Principles of Creating a Marked Corpus of Learners’ Mistakes
Authors: Vinogradova Yuliya , Il'chenko Igor' , Shiryaeva Polina , Gorina Mariya
Published: October 2024

Today, academic corpora are a matter of great interest to many linguists. The article examines the importance of academic corpora in modern linguistics and pedagogy as a tool for identifying typical errors in the speech of foreign language students. They reveal problems in foreign language acquisition and create new teaching methods. The paper reviews the existing academic corpora and error classifications. The authors developed a corpus of oral speech errors typical of Russian-speaking IT students that study English for IT purposes. The corpus relied on 50 video recordings of in-class activities in which students communicated with English-speaking IT specialists and made up dialogues in English. The corpus made it possible to identify the main difficulties experienced by adult learners of English for IT purposes. It involves a tagged classification of typical errors divided by language level into morphological, syntactic, lexical, and phonetic ones. The research demonstrated good prospects for developing other academic speech corpora with automated error tagging based on the speech of English learners.
Social and Socio-Political Deviations in University Students: Digital Traces in Regional Online Communities
Authors: Nyatina Natal'ya , Golovatsky Evgeny
Published: October 2024

Deviant behavior is a popular research topic. The article examines interdisciplinary approaches to its causes, types, and consequences in university students. Constructive deviation is a relatively new phenomenon, which requires systematization and formalization. The current socio-political changes encourage certain socially significant values and helping behavior practices, which makes it possible to develop social resources, as well as social, intellectual, and civic potential in young people. The authors studied internet activities of first-year university students to reveal the social and political prerequisites of constructive deviation. These foundations included the institutional conditions for the development and implementation of the state youth policy, youth initiatives, helping behavior practices, hypernormality, such socially significant values as patriotism and altruism, etc. The sociological interpretation of constructive deviation clarifies the challenges that are relevant for young people and directions for their social consolidation.
Oilfield produced water and constructed wetlands technology: a comprehensive review
Authors: Nyieku Florence Esi , Kabutey Felix Tetteh , Kyei Sampson Kofi , Essandoh Helen M. K. , Armah Frederick Ato , Awuah Esi
Published: October 2024

Produced water is the largest waste byproduct from the oil and gas industry with elevated levels of salts, metals, and organic constituents. This comprehensive review summarizes (1) the potential impact, (2) produced water management, and (3) identifies current research thrust areas in future efforts. Complementary treatment systems involving chemical and biological techniques offer significant advantages. The review emphasizes the application of these technologies and their performance in meeting regulatory standards. Cost, energy consumption, chemical use, and operational complexity are recognized challenges in both the water treatment industry and the oil and gas industry. It highlights the need for further research and for the optimization of processes to enhance their efficiency. The integration of conventional methods with advanced treatment processes is also explored, with a vision toward developing hybrid systems for improved treatment efficiency. Overall, complementary systems show great promise for the treatment of produced water, but further advancements, sustainability considerations, and integration with other technologies are essential for their successful implementation in large-scale applications. Maintaining expertise and awareness of water treatment issues in the oil and gas industry can help reclamation identify new technologies and solutions to technical challenges that may benefit the oilfield water treatment industry.
ZAGROŻENIA I KIERUNKI ZMIAN POLSKIEGO ŁADU
Authors: Kobylski Piotr
Published: October 2024

W literaturze przedmiotu od lat postuluje się stworzenie przyjaznego i dogodnego systemu podatkowego. W ten sposób byłoby to korzystne zarówno dla podatników, jak i dla budżetu państwa, ponieważ odpowiednie warunki płatności upraszczają zapłatę podatków, powiększając zasoby podatkowe. Polski Ład miał stać się odpowiedzią prawodawcy na liczne mankamenty dotychczasowego systemu podatkowego. W obliczu poczynionych zmian w systemie podatkowym nie sposób nie zauważyć, że założenia Polskiego Ładu były nierealne, niepoparte konkretami, ograniczono się bowiem do ogólnikowych sformułowań. W ten sposób zdecydowano się na wprowadzenie Polskiego Ładu 2.0, który miał wyeliminować te wypaczenia. Niniejsza inicjatywa również wzbudziła niepokój wśród podatników. Na tle powyższych uwag należy się zastanowić, czy podjęte działania przez ustawodawcę pozwoliły na stworzenie właściwie funkcjonującego modelu systemu podatkowego. Głównym zamierzeniem badawczym jest charakterystyka tego, jaki wpływ mają wymienione powyżej regulacje prawne dla ustalenia zakresu ich oddziaływania na system podatkowy. Celem opracowania jest zatem wskazanie, w jakim zakresie i na jakiej podstawie prawodawca założył, że wypracowane rozwiązania prawne zadecydują o dobrze funkcjonującym modelu systemu podatkowego.
Romanista ‘honoris causa’. Uwagi na marginesie monografi Piotra Bilińskiego, Adam Vetulani (1901-1976). Historyk prawa polskiego i kanonicznego, Wydawnictwo Uniwersytetu Jagiellońskiego, Kraków 2023, ss. 414
Authors: Jońca Maciej
Published: October 2024

W roku 2023 na rynku polskim ukazała się naukowa biografa Adama Vetulaniego, profesora Uniwersytetu Jagiellońskiego i jednego z najwybitniejszych polskich historyków prawa XX w. Jej autor Piotr Biliński nadał mu w tytule przydomek: „historyk prawa polskiego i kanonicznego”. Prezentowany artykuł ma charakter suplementu i zarazem kompendium dla uczonych zajmujących się prawem rzymskim. Celem moim jest pokazanie znacznego wkładu Adama Vetulaniego w badania nad historią prawa rzymskiego (zwłaszcza w okresie średniowiecza) oraz w jego popularyzację.
The Gut Health Revolution: Herbs and Dietary Phytochemicals in Balancing Gut Microbiota for Optimal Human Health
Authors: Khan Afeefa , Abass Sageer , Nizami Syed Ali Imam , Shariq Mohd , Zahiruddin Sultan , Parveen Bushra , Parveen Rabea
Published: October 2024

The gut microbiota is a varied population of microorganisms that live in the human
gastrointestinal system. Emerging research emphasizes the importance of this microbial ecology
in general health and its influence on a variety of disorders. The review explores the synergy
between herbal treatment and traditional medicine, emphasizing their cultural significance and
therapeutic benefits. It delves into the intricate relationship between herbal remedies, traditional
healing practices, and their sustained usage over centuries. The review highlights the pivotal role
of the gut microbiota in herbal medicine, elucidating how treatments influence the gastrointestinal
microorganisms, impacting overall health. Dietary phytochemicals are underscored for their
significance in herbal medicine and nutritional well-being, along with the interdependence of
plant extracts and botanicals. The investigation explores the molecular connections between
phytoconstituents and gut microbiota, aiming to deepen the understanding of herbal medicine's
tailored approach to specific health challenges. The summary concludes by emphasizing herbal
treatments' unique ability to regulate gut flora, contributing to overall gastrointestinal wellbeing.
In closing, the review provides a concise overview, serving as a valuable resource for
integrative medicine research, with recommendations for future exploration of herbal medicine's
potential in healthcare.
An Overview of Research Advances in Oncology Regarding the Transcription Factor ATF4
Authors: Chen Yulu , Gao Qi , Wang Dan , Zou Xun , Li Xiuming , JI Jing , Liu Bin
Published: October 2024

This review provides a comprehensive overview of the recent advancements in research
on ATF4 (Activating Transcription Factor 4) within the field of oncology. As a crucial transcription
factor, ATF4 has garnered increasing attention for its role in cancer research. The review
begins with an exploration of the regulatory mechanisms of ATF4, including its transcriptional
control, post-translational modifications, and interactions with other transcription factors. It then
highlights key research findings on ATF4's involvement in various aspects of tumor biology, such
as cell proliferation, differentiation, apoptosis and survival, invasion and metastasis, and the tumor
microenvironment. Furthermore, the review discusses the potential of targeting ATF4 as a novel
therapeutic strategy for cancer treatment. It also explores how ATF4's interactions with existing
anticancer drugs could inform the development of more effective therapeutic agents. By elucidating
the role of ATF4 in tumor biology and its potential clinical applications, this review aims to
provide new insights and strategies for cancer treatment.
Targeting MGST1 Makes Non-Small Cell Lung Cancer Cells Sensitive to Radiotherapy by Epigenetically Enhancing ALOX15-Mediated Ferroptosis
Authors: Ma Yechen , Peng Yuping , Cheng Shulin , Jin Long
Published: October 2024

Background:

Ferroptosis is closely related to radiotherapy resistance in multiple can-cers. Herein, the role of microsomal glutathione S-transferase 1 (MGST1) in regulating ferropto-sis and radiotherapy resistance in non-small cell lung cancer (NSCLC) was investigated.

Methods:

Radiation-resistant NSCLC cells (NCI-1299-IR and HCC827-IR cells) were estab-lished. After exposure to X-ray, cell proliferation and survival were assessed by colony formation assay and CCK-8 assay, and lipid ROS level was examined by the fluorophore BODIPY™ 581/591 C11. MDA, GSH, and Fe2+ levels were measured by ELISA kits. The molecular interac-tion was analyzed using ChIP and MSP assays.

Results:

Our results showed that RSL3 treatment greatly enhanced the radiotherapy sensitivity of NCI-1299-IR and HCC827-IR cells. It was subsequently revealed that MGST1 was highly ex-pressed in NCI-1299-IR and HCC827-IR cells than its parent cells, and silencing of MGST1 re-duced radioresistance of NCI-1299-IR and HCC827-IR cells by facilitating ferroptosis. Mechanis-tically, MGST1 knockdown greatly reduced HO-1 and DNMT1/3A protein levels, leading to re-duced DNA methylation on the ALOX15 promoter region, thereby epigenetically upregulating ALOX15 expression. As expected, the promoting effects of MGST1 silencing on radiosensitivity and ferroptosis in radiation-resistant NSCLC cells were strikingly eliminated by ALOX15 knock-down.

Conclusion:

MGST1 knockdown epigenetically enhanced radiotherapy sensitivity of NCSLC cells by promoting ALOX15-mediated ferroptosis through regulating the HO-1/DNMT1 pathway.

other:

None.
An Overview of the Phytochemical and Therapeutic Potential of Wrightia Tinctoria
Authors: Jurel Priyanka , Bahadur Shiv , Bajpai Meenakshi
Published: October 2024

Introduction:

Several natural phytomedicines derived from Chinese herbs demonstrate
a wide range of pharmacological effects. Wrightia tinctoria (WT) is a small deciduous tree
known as sweet indrajao. It belongs to the Apocynaceae family. Many diseases have been treated
with this plant's phytoconstituents, such as skin disorders, dysenteric, diarrhea, and hair treatments.
In addition, the therapeutic elements of WT demonstrate significant anti-inflammatory and
anti-dandruff properties. However, there is a difference between this plant's preclinical and clinical
significance. The purpose of this study is to collect and evaluate the various chemical, medicinal,
and pharmacological characteristics of WT in relation to multiple disorders using preclinical
evidence. This will serve as a valuable foundation for researchers to explore its effectiveness in
clinical trials further.

Materials and Methods:

A comprehensive search was conducted across several databases, including
PubMed, Web of Science, Scopus, Academic Journals Embase, Google Scholar, and Science
Direct. The search utilized specific keywords such as "Wrightia tinctoria" as well as terms
like "Traditional Chinese Medicine," "Pharmacological activities," "Anti-cancer," "Anti-viral,"
"Anti-microbial," "Anti-psoriatic," "Anti-Inflammatory," "Quercetin" and their combinations
mainly from 1993 to 2024.

Results:

The pharmacological and therapeutic potential of WT is gathered and summarized based
on existing research reports. WT substances consist of various phytoconstituents, including flavonoids,
steroids, alkaloids, volatile oils, esters, and others. These components are primarily responsible
for the various pharmacological effects of WT, such as anti-oxidant, anti-bacterial, antifungal,
anti-diabetic, anti-cancer, anti-microbial, anti-inflammatory, and anti-ulcer effects.

Conclusion:

This review focuses on current research findings regarding WT's therapeutic potential
and pharmacological activities. Additionally, it addresses the major safety and toxicity issues
related to WT.
An Overview of Pharmacological Profile of Flavonoids as Potential Molecules of Therapeutic Importance
Authors: Kumar Abhay , Rakhi  , Kumar Vipul , Dahiya Saurabh , Kumar Sahil , Kumar Vijender
Published: October 2024

A growing number of research investigations have shown the multiple health benefits of
flavonoids derived from plants, leading to interest in the field. Many recent studies have concentrated
on flavonoids effects on human health. Flavonoids are effective against a wide spectrum of bacteria,
viruses, and other pathogens. Numerous flavonoids have been demonstrated to possess antioxidative,
free radical scavenging, hepatoprotective, antiinflammatory, anticancer, and coronary heart disease
preventive properties. Some of novel flavonoids having therapeutic potential as new medication have
been identified which include hesperetin-5′-O-β-rhamnoglucoside, Resveratrol, Astragalin (AST)
Desmodinosides A-E: New Flavonoid C-glycosides, Apigenin, Luteolin, and Baicalein, rutin, hyperoside
etc. Some recent developments including clinical trials of a few of the flavonoids discussed in
the review provide a novel library of pharmacologically potential molecules which provides a paradigm
for the treatment of several ailments such as SARS-CoV-2, Alzheimer's disease, diabetes, angina
pectoris, Hepatitis C virus and Sickle cell disease (SCD) etc. The present review aims at updating
recent flavonoid advancements for various pharmacological actions, from conventional therapeutic
implications to upcoming clinical trials. We encourage researchers to focus on flavonoids for a variety
of medicinal applications since the industrial acceptance of these compounds will determine the future
growth of this field.
Drug-Induced Mitochondrial Disruption in the Blood-Brain Barrier Cells: Overlooked Player in Drug Safety Evaluation
Authors: Elmorsy Ekramy
Published: October 2024

The blood-brain barrier (BBB) is based on the unique pattern of the microvasculature
of the central nervous system (CNS), which controls the transport of molecules between the CNS
and the blood. The blood-brain barrier is mainly composed of endothelial cells, pericytes, and
basement membrane, as well as the astrocytes and immune cells as perivascular macrophages
and microglial cells. The dysfunction of this barrier can cause serious neuronal disorders due to
the transport of hazardous molecules and immune cells to the CNS. Mitochondria plays a major
role in cellular homeostasis in terms of health and disease. This review evaluated the published
data about the effect of the drugs on the cells of BBB. Only seven articles were found that considered
the effect of drugs on the barrier endothelial cells and mitochondria via different assays.
Further studies are recommended to evaluate the impact of used medications on BBB cell bioenergetics.
Also, the effect of the newly studied pharmaceutical agents on the BBB bioenergetics
should be included within their safety profile studies.
The PARK2_e01(-697) Polymorphism does not Associate with Susceptibility to Typhoid in Punjabi Population, Pakistan: A Case Control Study
Authors: Kousar Rizwana , Waheed Ayesha , Naz Rida , Raja Ghazala Kaukab , Kalsoom Umm-e , Latif Sadia
Published: October 2024

Background:

SNP based association studies have revolutionized the field of biomed-icines. Enteric fever is a systemic disease with etiologic agents Salmonella enterica serovar typhi and paratyphi. It is a serious health issue worldwide and presents wide variations in incidence, rates, and severity. Previous investigations have revealed that genetic variations may lead to sus-ceptibility to typhoid fever. A current study was performed to investigate the potential association of PARK2_e01(−697) polymorphism with the susceptibility to typhoid in the Punjabi population.

Methods:

For this case-control study, blood samples obtained from typhoid patients with positive Typhidot or blood culture test (n=72) and healthy controls (n=73) were processed for DNA ex-traction. The polymorphism PARK2_e01(-697) analysis was carried out by using PCR and RFLP.

Results:

No allelic association was found between PARK2_e01(-697) and susceptibility to ty-phoid fever in the understudy population.

Conclusion:

This case control study is the demonstration of the non-association of PARK2_e01(-697) with typhoid in the Pakistani population. Future research, using a larger population size, will help to elucidate the role of PARK2_e01(-697) polymorphism in typhoid pathogenesis.
Synergistic Structural Inhibition of MMP-9 by Natural Flavonoids: A Natural Combinatorial Therapy against Cancer
Authors: Singh Mahendra Pratap , Shivhare Brijesh , Pandey Anand Kumar
Published: October 2024

Introduction:

Cancer is the uncontrolled proliferation of cells leading to metastasis due
to genetic alterations resulting in oncogenes activation and tumor suppressor genes deactivation. It
is the 2nd leading cause of death across the world. MMP-9 or gelatinase B, plays an effective role
in ECM degradation, normal tissue turnover, and tissue remodelling. Overexpression of MMP-9
has been studied in almost all types of cancers proving the effective role of MMP-9 in accelerating
malignant conditions. Thus, targeting MMP-9 to treat cancer seems to be a potential strategy
to deal with adverse pathologies of cancer. Chemotherapy and radiotherapy are frequently utilized
for the treatment of cancer but are associated with diverse side effects. Flavonoids are natural compounds
frequently found in plants and have been analysed for the structural inhibition potential
against MMP-9 by several researchers to develop natural treatments against cancer, but none of
the flavonoids have landed into clinical use.

Methods:

In the present study, in-depth in-silico analysis to investigate the synergistic effects of
flavonoids for structural inhibition of MMP-9 was done.

Results:

The ADMET and bioactive properties analysis revealed effective drug-like properties of
the considered flavonoids. Principal component analysis of ADMET and bioactive properties revealed
high similarity in the chemical nature of luteolin and quercetin. Molecular docking analysis
of MMP-9 with the considered flavonoids individually revealed the highest effective binding energy
of luteolin. Combination docking analysis of MMP-9 with different combinations of flavonoids
led to the identification of two combinations including Quercetin with Genistein and Luteolin and
Genistein revealing high negative binding energies of -15.48kcal/mol and -15.31kcal/mol which
were significantly greater than the binding energies identified for respective ligands in individual
dockings.

Conclusion:

Thus, the present study put forward synergistic natural flavonoid combinations
against cancer via the MMP-9 inhibition approach that can be further evaluated to develop high-efficacy
treatments.
Preparations, Applications, Patents, and Marketed Formulations of Nanoemulsions - A Comprehensive Review
Authors: Chauhan Mansi , Mazumder Rupa , Rani Anjana , Mishra Rashmi , Pal Rashmi Saxena
Published: October 2024

Nanoemulsions have emerged as versatile colloidal dispersions with promising applications
in various fields, including pharmaceuticals, food, and cosmetics. These nano-sized emulsions,
stabilized by surfactants, offer unique advantages such as enhanced ingredient penetration
efficacy and versatile dosage forms. This article provides an extensive overview of nanoemulsions,
covering their composition, methods of preparation, and applications in drug delivery, the
food industry, and cosmetics. Various high-energy and low-energy methods for nanoemulsion preparation
are discussed, along with their advantages and limitations. Additionally, the article highlights
the potential of nanoemulsions in improving drug bioavailability, stability, and therapeutic
efficacy, especially in oral, topical, parenteral, intranasal, ocular, and pulmonary drug delivery.
Furthermore, nanoemulsions are explored as carriers for encapsulating flavoring agents, nutraceuticals,
and natural preservatives in the food industry, as well as their use in cosmetic formulations.
Current clinical trials involving nanoemulsions and recent patents in the field are also summarized,
providing insights into ongoing research and development efforts. Lastly, a selection of
marketed nanoemulsion formulations is presented, showcasing their practical applications and
commercial availability. Overall, nanoemulsions hold great promise as effective delivery systems
with broad applications across various industries.
Role of Clinical Pharmacists in Infectious Disease Ward
Authors: Ayhan Yunus Emre , Kara Emre
Published: October 2024

Irrational use of antimicrobial agents has led to the emergence of
antimicrobial resistance. The Infectious Diseases Society of America and The Centers
for Disease Control and Prevention recommend that a clinical pharmacist with
infectious diseases training should participate in the antimicrobial stewardship teams.
Several authors stated that antimicrobial stewardship effectively reduces inappropriate
antimicrobial use, cost, and hospital stays. Prospective audits and feedback can reduce
the inappropriate use of antimicrobials. Clinical pharmacists may help orient the
healthcare team on selecting appropriate antimicrobial agents, administration routes,
dosing, treatment discontinuation, monitoring for toxicities, and therapeutical drug
monitoring. Clinical pharmacists are important members of antimicrobial stewardship
in the inpatient and outpatient settings. Antimicrobial stewardship pharmacists should
have a role that includes designing and implementing antimicrobial stewardship
interventions, measuring outcomes and relevant data, and management strategies. The
participation of pharmacists in antimicrobial stewardship programs may increase
compliance with guideline recommendations of antimicrobial therapies and improve
adherence and response to treatment. Clinical pharmacist recommendations can also
help prevent medication errors, such as missing or incorrect medications, inappropriate
dosing, drug-drug interactions, or inadequate renal and hepatic function adjustment.
This book chapter highlights the roles of an infectious disease-trained clinical
pharmacist in the infectious diseases ward.
Role of Clinical Pharmacists in Pediatric Disease Wards
Authors: Mercumek Berre , Sahin Yeliz
Published: October 2024

Effective medication therapy management is essential in addressing
pediatric pharmacotherapy's unique challenges, as pediatric patients are distinct from
adults in terms of physiological and pharmacological characteristics. This management
requires a multidisciplinary team to provide optimal care, with clinical pharmacists
specializing in pediatrics playing a role in ensuring safe and effective medication use in
this patient population. This chapter reviews clinical pharmacists' roles and
responsibilities in these settings, including participation in interdisciplinary rounds,
medication reconciliation and review, and patient counseling. In addition, this chapter
investigates the essential knowledge required to fulfill the roles and responsibilities of
clinical pharmacists in pediatric care settings, which include a basic understanding of
common pediatric diseases and medications, clinical guidelines, tools used to provide
clinical pharmacy services, identification and prevention of drug-related problems, and
clinical competencies. Additionally, this chapter discusses the current evidence on the
impact of clinical pharmacy services on outcomes such as medication errors, adverse
drug events, and treatment efficacy in pediatric disease wards and the literature on the
roles of clinical pharmacists in pediatric wards. Overall, this chapter emphasizes the
critical importance of integrating clinical pharmacists as essential healthcare team
members in pediatric disease wards to enhance the quality of care and improve patient
outcomes.
Role of Clinical Pharmacists in the Cardiology Ward
Authors: Altıparmak Öznur , Apikoğlu Şule
Published: October 2024

The provision of healthcare to cardiology patients requires a
multidisciplinary team, including a clinical pharmacist as a member, to ensure optimal
medication management. In this chapter, the benefits and challenges of the presence of
a clinical pharmacist as a team member in cardiology care are briefly presented from a
general perspective. In addition, medication management and input of clinical
pharmacists in the most common cardiovascular conditions (i.e., acute coronary
syndrome, hypertension, pulmonary hypertension, heart failure, atrial fibrillation) are
reviewed. The most prominent outcomes of the clinical pharmacists’ interventions are
reduced drug-related problems, increased medication adherence, improved healthcare
outcomes such as reduced blood pressure levels, and prevention of hospital
readmissions. Also, leading cardiology guidelines as means of evidence-based
pharmaceutical care are listed. Overall, this chapter aims to emphasize the importance
of incorporating clinical pharmacists in cardiology healthcare teams to provide
comprehensive care for patients.
A Feminist Autoethnography of a Family Archive: Affects, Narratives and Practices During Two World Crises: World War II and Covid-19
Authors: Lerma Mayer Sonia Yuruen
Published: October 2024

What happens when we, as researchers, are living through a world crisis such as Covid-19, whilst studying a family epistolary archive produced during World War Two, another world crisis? What epistemological and methodological bridges can be made between the personal experiences of two women (great aunt and great niece) living in two moments of history but who are connected by the process of writing and reading epistolary documents? By conducting a feminist autoethnography of my experience in the Covd-19 pandemic, I reflect upon what it has meant to do feminist historic and archival research of the experience of Trixie Mayer, the first Mexican volunteer to join the Women’s Auxiliary Air Force in Great Britain from 1942 to 1946 and who produced more than 200 personal documents during her war work and afterwards kept them, together with the documents she received form her family in Mexico, for more than 70 years. I analyse how living through a pandemic has helped me understand my great aunt’s crisis experiences from a different perspective, questions, partialities and, at the same time, how these personal and familiar writings have helped me understand and question our current reality and PhD thesis from an alternative perspective.