bluuebunny/crossref_metadata_2025 huggingface dataset:
Bolus rheology of texture adjusted food—Effect of age
Authors: Stading Mats , Miljkovic Ana , Andersson Johanna , Matsuo Koichiro
Published: July 2023

Swallowing disorders, or dysphagia, affect a large part of the population due to factors such as degenerative diseases, medication side effects or simply age‐related impairment of physiological oropharyngeal function. The management of dysphagia is mainly handles through texture‐modified foods of progressively softer, smoother, moister textures, depending on the severity of the disorder. Rheological and physiological‐related properties of boluses were determined for a group of five older persons (average age, 74) for a set of texture‐modified foods: bread, cheese and tomato and the combination into a sandwich. The softest class was gel food, after which came a smooth timbale; both were compared to boluses of regular food. The subjects chewed until ready to swallow, at which point the bolus was expectorated and measured regarding saliva content, linear viscoelasticity and shear viscosity. The results were compared to those of a previously studied younger group (average age, 38). The general physiological status of the subjects was determined by hand and tongue strength, diadochokinesis and one‐legged standing and showed that all subjects were as healthy and fit as the younger group. Age‐related properties such as one‐legged standing with closed eyes and salivary flow plus bolus saliva content were lower for the older group, but the average chews‐until‐swallow was surprisingly also lower. Consequently, bolus modulus and viscosity were higher than for the younger group. Overall, the intended texture modification was reflected in bolus rheological and physiological‐related properties. Bolus modulus, viscosity, saliva content and chews‐until‐swallowed all decreased from regular food to timbale food to gel food.
Which Aspects of Visual Motivation Aid the Implicit Learning of Signs at First Exposure?
Authors: Hofweber Julia , Aumônier Lizzy , Janke Vikki , Gullberg Marianne , Marshall Chloë
Published: July 2023

We investigated whether sign‐naïve learners can infer and learn the meaning of signs after minimal exposure to continuous, naturalistic input in the form of a weather forecast in Swedish Sign Language. Participants were L1‐English adults. Two experimental groups watched the forecast once (n = 40) or twice (n = 42); a control group did not (n = 42). Participants were then asked to assign meaning to 22 target signs. We explored predictors of meaning assignment with respect to item occurrence frequency and three facets of visual motivation: iconicity, transparency, and gesture similarity. Meaning assignment was enhanced by exposure and item frequency, thereby providing evidence for implicit language learning in a new modality, even under challenging naturalistic conditions. Accuracy was also contingent upon iconicity and transparency, but not upon gesture similarity. Meaning assignment at first exposure is thus visually motivated, although the overall low accuracy rates and further qualitative analyses suggest that visually motivated meaning assignment is not always successful.
Philosophers ought to develop, theorize about, and use philosophically relevant AI
Authors: Clay Graham , Ontiveros Caleb
Published: July 2023

The transformative power of artificial intelligence (AI) is coming to philosophy—the only question is the degree to which philosophers will harness it. This paper argues that the application of AI tools to philosophy could have an impact on the field comparable to the advent of writing, and that it is likely that philosophical progress will significantly increase as a consequence of AI. The role of philosophers in this story is not merely to use AI but also to help develop it and theorize about it. In fact, the paper argues that philosophers have a prima facie obligation to spend significant effort in doing so, at least insofar as they should spend effort philosophizing.
Food insecurity in people living with obesity: Improving sustainable and healthier food choices in the retail food environment—the FIO Food project
Authors: Lonnie Marta , Hunter Emma , Stone Rebecca A. , Dineva Mariana , Aggreh Modupe , Greatwood Hannah , Johnstone Alexandra M. ,   the FIO Food team
Published: July 2023

At both UK and global level, dietary consumption patterns need to change to address environmental, health and inequality challenges. Despite considerable policy interventions, the prevalence of overweight and obesity in the United Kingdom has continued to rise with obesity now a leading cause of mortality and morbidity. Obesity prevalence is greater among those on lower incomes and the current UK food system, including government policy, does not effectively address this. Current behavioural approaches, without the support of structural changes in the system, may even widen the inequalities gap. Hence, using behavioural insights from those living with obesity and food insecurity, the project will explore potential avenues that can be applied in the food system to promote healthier choices in the food retail environment. The National Food Strategy report recommends that the UK food system should ensure “safe, healthy, affordable food; regardless of where people live or how much they earn”. However, the association between food insecurity and the development of obesity is not well understood in relation to purchasing behaviours in the UK retail food environment, nor is the potential effectiveness of interventions that seek to prevent and reduce the impact of diet‐induced health harms. The FIO Food (Food insecurity in people living with obesity – improving sustainable and healthier food choices in the retail food environment) project provides a novel and multi‐disciplinary collaborative approach with co‐development at the heart to address these challenges. Using four interlinked work packages, the FIO Food project will combine our knowledge of large‐scale population data with an understanding of lived experiences of food shopping for people living with obesity and food insecurity, to develop solutions to support more sustainable and healthier food choices in the UK retail food environment.
Automatic calibration of terrestrial laser scanners using intensity features
Authors: Qiao Jing , Medic Tomislav , Baumann‐Ouyang Andreas
Published: July 2023

We propose an in situ self‐calibration method by detecting and matching intensity features on the local planes in overlapping point clouds based on the Förstner operator. We successfully matched the intensity features from scans at different locations by feature matching on common local planes rather than on the rasterised grids of the horizontal and vertical angles adopted by the affirmed keypoint‐based algorithm. The capability of extracting features from different stations offers the possibility of comprehensive scanner calibration, solving the disadvantage that the existing keypoint‐based methods can only estimate the two‐face‐sensitive model parameters. The proposed algorithm has been tested with a high‐precision panoramic scanner, Leica RTC360, using datasets from a calibration hall and a general working scenario. It has been shown that the proposed approach consistently calibrates the two‐face‐sensitive model parameters with the affirmed keypoint‐based one. For the case of comprehensive calibration with the offset estimated and some angular parameters separated where the previous keypoint‐based one failed, the proposed algorithm achieves an accuracy of 0.16 mm, 2.7″ and 2.1″ in range, azimuth and elevation for the estimated target centres. The proposed algorithm can accurately calibrate two‐face‐sensitive and more comprehensive model parameters without any preparation on‐site, for example, mounting targets.
Optimisation of sample geometry for thermo‐mechanical testing of precipitation hardenable nickel‐based superalloys with an ETMT machine
Authors: King Michael , Rahimi Salaheddin
Published: July 2023

Accurate determination of thermo‐mechanical properties in precipitation hardenable materials using an electro‐thermal mechanical testing (ETMT) system is a well‐established challenge. The non‐uniform distribution of temperature resulting from heating based on the joule effect (i.e., resistivity heating) leads to heterogeneous deformation along the gauge length, owing to the temperature dependency of mechanical properties, which makes their direct measurements complicated. This study presents an evaluation of four different miniaturised sample geometries that were tested to achieve an optimised sample with acceptable uniform strain and temperature distributions in the gauge volume. In‐situ displacement mapping, using digital image correlation (DIC), was utilised to calibrate the optimised sample dimensions with the aim of forcing the deformation to the hottest region of the gauge lengths during the tests. Tests were carried out on Inconel 718 (IN718) at 720°C, an optimal temperature for the precipitation of γ″, the primary strengthening particle in this alloy. The results showed that only in the case of the geometry proposed in this study (i.e., a sample with a short gauge length [~2 mm]) did the deformation acceptably localise at the centre, compared to other geometries. A correction methodology is developed that equates the strain measured using DIC over the 2 mm gauge length of the modified sample geometry with the strain measured using the linear variable differential transformer (LVDT) integrated to the ETMT, making future tests on IN718, and other precipitation hardenable materials, possible without the need for the use of a DIC system.
Enumeration and Identification of Unique 3D Spatial Topologies of Interconnected Engineering Systems Using Spatial Graphs
Authors: Peddada Satya R. T. , Dunfield Nathan M. , Zeidner Lawrence E. , Givans Zane R. , James Kai A. , Allison James T.
Published: July 2023

Systematic enumeration and identification of unique 3D spatial topologies (STs) of complex engineering systems (such as automotive cooling systems, electric power trains, satellites, and aero-engines) are essential to navigation of these expansive design spaces with the goal of identifying new spatial configurations that can satisfy challenging system requirements. However, efficient navigation through discrete 3D ST options is a very challenging problem due to its combinatorial nature and can quickly exceed human cognitive abilities at even moderate complexity levels. This article presents a new, efficient, and scalable design framework that leverages mathematical spatial graph theory to represent, enumerate, and identify distinctive 3D topological classes for a generic 3D engineering system, given its system architecture (SA)—its components and their interconnections. First, spatial graph diagrams (SGDs) are generated for a given SA from zero to a specified maximum number of interconnect crossings. Then, corresponding Yamada polynomials for all the planar SGDs are generated. SGDs are categorized into topological classes, each of which shares a unique Yamada polynomial. Finally, within each topological class, 3D geometric models are generated using the SGDs having different numbers of interconnect crossings. Selected case studies are presented to illustrate the different features of our proposed framework, including an industrial engineering design application: ST enumeration of a 3D automotive fuel cell cooling system (AFCS). Design guidelines are also provided for practicing engineers to aid the application of this framework to different types of real-world problems such as configuration design and spatial packaging optimization.
API RP 574: Inspection Practices for Piping Components
Authors: Matthews Clifford
Published: July 2023

This chapter is about becoming familiar with the layout and contents of API RP 574: Inspection Practices for Piping System Components. You can think of RP 574 as the ‘general piping knowledge’ part of the BoK. It is strongly linked to API 570 and supplements information that appears in it. We saw in previous chapters how linking of codes is a feature of the API/ASME approach to plant inspection (and the ICP exams).
API 510 Section 5: Inspection Practices
Authors: Matthews Clifford
Published: July 2023

Section 5 of API 510 is actually called Inspection, Examination and Pressure Testing Practices and contains many of the principles on which the BoK (and exam) are based. It’s 17 pages long but still relies on additional information included in Sections 6 and 7 to give the full picture of what API consider is involved in the inspection of pressure vessels. Look back at Figure 21.3. Taken together, these three sections make up 30 pages – more than 70% of the entire document and its source of exam questions.
API 650 Tank Design
Authors: Matthews Clifford
Published: July 2023

As the construction code for new tanks, API 650 sits in the background covering all the aspects of repair and reconstruction of a tank not specifically over-ridden by anything in API 653. API 650 contains detailed construction details for all parts of a tank. It is logically set out and easier to follow than, for example, ASME VIII-I for pressure vessels. Figure 34.1 shows the breakdown. Almost all the API 653 exam questions sourced from API 650 appear in the open-book section of the exam and are straightforward to track down once you find the correct section. Approximately half the code is taken up with 26 annexes at the end; however, only those shown in Figure 34.1 are in the BoK. Several only have one or two clauses of annex included in the BoK; these normally comprise a definition of some sort and make good points for examination questions.
API RP 571: Damage Mechanisms (API 653)
Authors: Matthews Clifford
Published: July 2023

The API 653 BoK contains several documents dealing with tank DMs. Table 38.1 shows a reminder of how the DMs of API RP 571 are appointed to the three main ICPs. The API 653 BoK contains ten DMs, fewer than for API 510 or 570. You can see there is no DM in the table that appears only in the 653 BoK.
API RP 577: Welding Processes, Inspection and Metallurgy
Authors: Matthews Clifford
Published: July 2023

A large amount of content is common to all three ICP BoKs. It has increased in recent years and fits well with the new multiple question styles now used in the ICP exams. This makes ICP exams easier to study for, once you have passed the first ICP certificate. Figure 7.1 shows the common areas. Note that for some documents (predominantly API RP 571, 576 and ASME V) only parts of them are common to all three BoKs, i.e. not the whole document.
Evaluating hydrophobic recovery of N2 and H2O(g) plasma modified silk fibroin films aged at ambient and elevated temperatures
Authors: Keobounnam Ashley N. , Lenert-Mondou Chase , Kubik Alexzandria , Hawker Morgan J.
Published: July 2023

Silk fibroin is a naturally derived polymer with great potential for biomedical use due to its strength, lack of immune response, and ability to biodegrade. The relatively hydrophobic nature of silk, however, can cause challenges with cell adhesion in vivo. Therefore, modification must be performed to improve the surface hydrophilicity, enhancing silk utility in the biomedical space. Low-temperature plasma (LTP) treatment is an established method for polymer modification and has the benefits of being a solvent-free, adaptable process. N2 and H2O(g) LTP treatments are both well-documented as strategies to enhance polar functional groups on a polymer's surface. However, many polymers tend to revert to their original hydrophobic state upon aging, reversing the effects of LTP modification. The hydrophobic recovery of N2 and H2O(g) LTP-modified silk has not been previously studied but has important implications for the uses and longevity of silk substrates in biomedical contexts. The goal of this study was to systematically evaluate the hydrophobic recovery of N2 and H2O(g) LTP-treated silk films. Films were LTP-modified using optimized plasma parameters (applied power, pressure, treatment time) and aged under both ambient and elevated temperature conditions up to 6 weeks after the initial treatment. Silk film surface properties were evaluated immediately after treatment and throughout the aging process using both water contact angle goniometry and x-ray photoelectron spectroscopy. LTP-treated silk films demonstrated a significant decrease in hydrophobicity compared to the untreated controls. Remarkably, both N2 and H2O(g) LTP modifications resulted in surfaces that retained hydrophilic properties over the 6 week aging period. Our findings represent a departure from what has been previously demonstrated in most LTP-modified synthetic polymers, suggesting that the secondary structure of silk fibroin plays a critical role in resisting hydrophobic recovery.
Virtual Motivation: The Psychological and Transfer of Learning Effects of Immersive Virtual Reality Practice
Authors: Markwell Logan T. , Velten Joei R. , Partridge Julie A. , Porter Jared M.
Published: July 2023

Previous research has shown practice within an immersive virtual reality (VR) environment improves performance in a physical environment. Increased user motivation is one possible advantage of practicing in VR. One recent study showed that an enriched gaming environment led to higher levels of engagement, resulting in a direct learning benefit. The purpose of this study was to compare the intrinsic motivation, engagement, and transfer of learning between VR practice and physical practice of the same motor skill. Participants (n = 61) were randomly assigned to a physical (n = 30) or a VR practice group (n = 31) in which they performed a golf putting task. Analyses showed VR practice led to a significantly greater increase in average intrinsic motivation inventory score than physical practice. Analyses for performance showed there was a significant (p < .001) improvement in accuracy (i.e., radial error) from pre- to posttest, but the two groups did not differ. Overall, these results partially support our hypotheses suggesting that VR practice led to a greater increase in motivation compared with physical practice. Additionally, these results suggest that VR practice was similarly effective at improving accuracy compared with physical practice. Future research directions are discussed.
Exploiting an epigenetic switch in adrenal cancer
Authors: Ferrarelli Leslie K.
Published: July 2023

EZH2 inhibitors may slow the progression of an aggressive form of adrenocortical cancer.
Sources of Substance and Genetic Relation of Soil and Bauxite-Bearing Horizons in the Laterite Profile of the Weathering Crust (of the Fouta Jallon–Mandingo Province, Republic of Guinea)
Authors: Makarova M. A. , Shipilova E. S. , Boeva N. M. , Vnuchkov D. A. , Bortnikov N. S.
Published: July 2023

For the first time, a granulometric analysis of lateritic soils was carried out and the sources of the substance involved in the formation of the degradation zone in the bauxite-bearing laterite profile of the bauxite-bearing province of Futa Jallon-Mandingo were identified. Throughout the province, on the stony rocks of the lateritic covers, the soil horizon occurs everywhere—the uppermost element of the vertical profile of the weathering crust. In the soil horizon, most of the components become mobile, leaching processes predominate, and laterites are mobilized and redistributed. The study of these continental formations made it possible to establish the genetic relationship between the soil horizon of the weathering crust and the underlying bauxite ores, and to determine the degree of influence of soil composition on the processes of bauxite formation.
Estimation of Methane Flow from the Bottom of the Kara Sea
Authors: Voropaev S. A. , Sevastyanov V. S. , Dushenko N. V. , Bryukhanov A. L.
Published: July 2023

During the expedition of cruise 81 on R/V Akademik Mstislav Keldysh in 2020, extensive material, representing columns of bottom sediments up to 6 m deep in the Kara Sea, was selected. After the lithological description of the columns, sediment samples were taken from the different horizons for degassing of pore gases. The extracted gas samples were analyzed for the content of the main gases, such as methane (CH4), carbon dioxide (CO2), and light hydrocarbons. The characteristic features of changes in the CH4 and CO2 content with the depth of the bottom sediments at station 6879 (the Kara Sea shelf) were studied. A model of gas diffusion was constructed taking into account the biochemical reactions of methanogenesis and methane oxidation. The rate of methane formation can be estimated by the value J ≈ 3 × 10−10 μg s−1 L−1 (per liter of sediment). The coefficient of rate of methane consumption by microorganisms is K ≈ 0.5 × 10−10 s−1. The methane flow from the bottom surface of the Kara Sea near station 6879 is q ≈ 3.47 × 10−1 μL m−2 yr−1.
Global Geodynamic Model of the Modern Earth and Its Application to the Antarctic Region
Authors: Baranov A. A. , Lobkovskii L. I. , Bobrov A. M.
Published: July 2023

A geodynamic model of the modern Earth was constructed based on the SMEAN 2 global seismic tomography model. Considering the distribution of mantle temperature anomalies in this model, the numerical simulation of a three-dimensional flow of a viscous mantle was carried out taking into account the dependence of the viscosity on temperature and depth in the spherical Earth. The Stokes equation was solved by the finite element method using the CitcomS code. The obtained data on the distribution of the temperature anomalies, dynamic topography, and velocity field in the mantle were used to analyze structural features and geodynamics in the West Antarctic region, as well as the anomalous acceleration of glacier movement and destruction in this area. In particular, the existence and current activity of the West Antarctic Rift System including one of the largest volcanic provinces on the Earth were explained. This explanation was consistent with the measurement data on increased heat flow on the surface. The increased heat flow and volcanic activity in this region lead to instability and accelerated runoff of the West Antarctic ice sheets into the ocean, thus posing the potential threat of a substantial rise in the global sea level.
Partially drained uplift behaviour of plant roots in dilative soils
Authors: Zhu Jun , Leung Anthony Kwan , Wang Yu
Published: July 2023

A large volume of research reporting the pull-out behaviour of root systems is available, but no study has considered the effects of soil drainage. This work implemented a modified three-dimensional embedded beam element model in a finite element platform that solved model equations by using a fully hydromechanically coupled algorithm. The model was validated against published centrifuge pull-out tests on root analogues, and the validated model was then applied to study parametrically the influence of the ratio of uplift rate to soil hydraulic conductivity on pull-out behaviour. The results demonstrated that the model can well capture the prepeak behaviour of the root systems up to the peak pull-out resistance. The generation of negative pore–water pressure ( p e x) owing to soil dilation upon root–soil interfacial shearing was the major reason for increased pull-out resistances under partially drained conditions. Compared with other root systems, root systems with smaller branch angles and deeper branch depths mobilised considerably more significant plastic deviatoric strains in the soil in their vicinity, generating more negative p e x. Hyperbolic dimensionless backbone curves were derived to explain the transitional pull-out behaviours of root systems of different geometries under drainage conditions that ranged from fully drained to undrained.
Molecular hydrogen: prospective treatment strategy of kidney damage after cardiac surgery
Authors: Kalocayova Barbora , Kura Branislav , Vlkovicova Jana , Snurikova Denisa , Vrbjar Norbert , Frimmel Karel , Hudec Vladan , Ondrusek Matej , Gasparovic Ivo , Sramaty Rastislav , Luptak Jaroslav , Hulman Michal , LeBaron Tyler W. , Slezak Jan
Published: July 2023

Cardiac surgery-associated acute kidney injury is a common post-operative complication, mostly due to increasing oxidative stress. Recently, molecular hydrogen (H2 gas) has also been applied to cardiac surgery due to its ability to reduce oxidative stress. We evaluated the potential effect of H2 application on the kidney in an in vivo model of simulated heart transplantation. Pigs underwent cardiac surgery within 3 h while connected to extracorporeal circulation (ECC) and subsequent 60 min of spontaneous reperfusion of the heart. We used two experimental groups: T—pigs after transplantation and TH—pigs after transplantation treated with 4% H2 mixed with air during inhalation of anesthesia and throughout oxygenation of blood in ECC. The levels of creatinine, urea and phosphorus were measured in plasma. Renal tissue samples were analyzed by Western blot method for protein levels of nuclear factor erythroid 2–related factor 2 (Nrf2), Kelch-like ECH-associated protein 1 (Keap-1), and superoxide dismutase (SOD1). After cardiac surgery, selected plasma biomarkers were elevated. However, H2 therapy was followed by the normalization of all these parameters. Our results suggest activation of Nrf2/Keap1 pathway as well as increased SOD1 protein expression in the group treated with H2. The administration of H2 had a protective effect on the kidneys of pigs after cardiac surgery, especially in terms of normalization of plasma biomarkers to control levels.
TDAN: Transferable Domain Adversarial Network for Link Prediction in Heterogeneous Social Networks
Authors: Wang Huan , Liu Guoquan , Hu Po
Published: July 2023

Link prediction has received increased attention in social network analysis. One of the unique challenges in heterogeneous social networks is link prediction in new link types without verified link information, such as recommending products to new overseas groups. Existing link prediction models tend to learn type-specific knowledge on specific link types and predict missing or future links on the same link types. However, because of the uncertainty of new link types in the evolving process of social networks, it is difficult to collect sufficient verified link information in new link types. Therefore, we propose the Transferable Domain Adversarial Network (
TDAN
) based on transfer learning to handle the challenge.
TDAN
exploits transferable type-shared knowledge in historical link types to help predict the unobserved links in new link types.
TDAN
mainly comprises a structural encoder, a domain discriminator, and an optimization decoder. The structural encoder learns the link representations in a heterogeneous social network. Subsequently, to learn transferable type-shared knowledge, the domain discriminator distinguishes link representations into different link types while minimizing the differences between type-specific knowledge in adversarial training. Inspired by the denoising auto-encoder, the optimization decoder reconstructs the learned type-shared knowledge to eliminate the noise generated during the adversarial training. Extensive experiments on Facebook and YouTube show that
TDAN
can outperform the state-of-the-art models.
Relationship of circulating levels of long-chain fatty acids to persistent organ failure in acute pancreatitis
Authors: Phillips Anna Evans , Wilson Annette S. , Greer Phil J. , Hinton Alice , Culp Stacey , Paragomi Pedram , Pothoulakis Ioannis , Singh Vijay , Lee Peter J. , Lahooti Ila , Whitcomb David C. , Papachristou Georgios I.
Published: July 2023

Drivers of the inflammatory response in acute pancreatitis remain incompletely understood. Unsaturated fatty acids, specifically palmitoleic, appear to have an association with more severe acute pancreatitis. This finding presents a new clinical understanding of fatty acid toxicity and highlights a potential future target for treatment in severe acute pancreatitis.
Obesity impacts hypoxia adaptation of the lung
Authors: Pankoke Sophia , Schweitzer Theresa , Bikker Rolf , Pich Andreas , Pfarrer Christiane , Mühlfeld Christian , Schipke Julia
Published: July 2023

An “obesity paradox” is discussed for pulmonary diseases. By linking lung proteome analyses to pulmonary structure and function, we demonstrate that diet-induced obesity affects lung adaptation to chronic hypoxia in various ways. The observed changes include not only adverse but also protective effects and are associated with altered abundances of vascular and extracellular matrix proteins. These results highlight the existence of relevant differences in individuals with obesity that may influence the pathogenesis of lung diseases.
A Computationally Efficient Estimator for the Target Angle, Delay, and Doppler Parameters in Passive Radar
Authors: Yang Jing , Liu Chengcheng , Huang Jie , Liu Dapeng , Ding Ting , Zhu Jiandong , Li Xia
Published: July 2023

The azimuth, elevation, time delay (TD), and Doppler shift (DS) of the target echo signal are important parameters for target localization in passive radar. In this paper, for the problem of joint estimation of target azimuth, elevation, TD, and DS parameters in passive radar, a computationally efficient estimator is proposed based on segmented coherent integration and uniform circular array (UCA) interferometer direction finding. First, according to the parameters of the target motion and illuminators of opportunity, the reference and surveillance signals are divided into segments, with fast time within a segment and slow time across the segments; then, matching filtering along the fast time and fast Fourier transform (FFT) along the slow time are performed to accumulate the target echo energy to the same delay-Doppler cell; finally, the UCA interferometer two-dimensional direction finding is performed at the delay-Doppler cell where the target echo is located, to achieve the target azimuth and elevation estimate. Simulation results demonstrate that the proposed algorithm has low computational complexity, high real-time processing capability, and can achieve efficient and real-time estimation of the azimuth, elevation, TD, and DS parameters of weak target echoes in passive radar.
Effect of Dietary Insect Meal and Grape Marc Inclusion on Flavor Volatile Compounds and Shell Color of Juvenile Abalone Haliotis iris
Authors: Bullon Natalia , Alfaro Andrea C. , Hamid Nazimah , Masoomi Dezfooli Sara , Seyfoddin Ali
Published: July 2023

Almost 60% of the fish meal produced globally is used in aquaculture feeds. Fish meal production relies on finite wild-marine resources and is considered as an unsustainable ingredient. Insect meal (IM) is considered a sustainable source with high levels of protein suitable for growth promotion. Grape marc (GM) is a waste byproduct of the winery industry rich in pigments with antioxidant capacity. However, the inclusion of both ingredients can affect the flavor of the meat of abalone and the color of the shell due to different nutritional profiles. The aim of this study was to evaluate the effect of the dietary inclusion of IM and GM on the flavor volatile compounds and shell color of the juvenile Haliotis iris in a 165-days feeding trial. Abalone were offered four experimental diets with different levels of IM and GM inclusion and a commercial diet (no IM or GM). Soft bodies of abalone were used to characterize volatile compounds using solid-phase microextraction gas chromatography–mass spectrometry, and color changes were analyzed in ground powder of abalone shells using color spectrophotometry 400–700 nm (visible). The results showed 18 volatile compounds significantly different among the dietary treatments. The inclusion of IM did not significantly affect the flavor volatile compounds detected, whereas the inclusion of GM reduced volatile compounds associated with lipid-peroxidation in abalone meat. The inclusion of IM and GM did not significantly affect the lightness nor the yellowness, blueness, redness, and greenness of the ground shells. The supplementation of abalone feeds with GM can help to reduce off-flavour compounds which may extend shelf-life of raw abalone meat.
Histone Methyltransferase NSD2 Activates PKCα to Drive Metabolic Reprogramming and Lenalidomide Resistance in Multiple Myeloma
Authors: Chong Phyllis S.Y. , Chooi Jing-Yuan , Lim Julia S.L. , Leow Aaron C.Y. , Toh Sabrina Hui Min , Azaman Irfan , Koh Mun Yee , Teoh Phaik Ju , Tan Tuan Zea , Chung Tae-Hoon , Chng Wee Joo
Published: July 2023

Multiple myeloma cells undergo metabolic reprogramming in response to the hypoxic and nutrient-deprived bone marrow microenvironment. Primary oncogenes in recurrent translocations might be able to drive metabolic heterogeneity to survive the microenvironment that can present new vulnerabilities for therapeutic targeting. t(4;14) translocation leads to the universal overexpression of histone methyltransferase NSD2 that promotes plasma cell transformation through a global increase in H3K36me2. Here, we identified PKCα as an epigenetic target that contributes to the oncogenic potential of NSD2. RNA sequencing of t(4;14) multiple myeloma cell lines revealed a significant enrichment in the regulation of metabolic processes by PKCα, and the glycolytic gene, hexokinase 2 (HK2), was transcriptionally regulated by PKCα in a PI3K/Akt-dependent manner. Loss of PKCα displaced mitochondria-bound HK2 and reversed sensitivity to the glycolytic inhibitor 3-bromopyruvate. In addition, the perturbation of glycolytic flux led to a metabolic shift to a less energetic state and decreased ATP production. Metabolomics analysis indicated lactate as a differential metabolite associated with PKCα. As a result, PKCα conferred resistance to the immunomodulatory drugs (IMiD) lenalidomide in a cereblon-independent manner and could be phenocopied by either overexpression of HK2 or direct supplementation of lactate. Clinically, t(4;14) patients had elevated plasma lactate levels and did not benefit from lenalidomide-based regimens. Altogether, this study provides insights into the epigenetic-metabolism cross-talk in multiple myeloma and highlights the opportunity for therapeutic intervention that leverages the distinct metabolic program in t(4;14) myeloma.

Significance:

Aberrant glycolysis driven by NSD2-mediated upregulation of PKCα can be therapeutically exploited using metabolic inhibitors with lactate as a biomarker to identify high-risk patients who exhibit poor response towards IMiD-based regimens.
Supplementary Table S4 from Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
Authors: Akshintala Srivandana , Sundby R. Taylor , Bernstein Donna , Glod John W. , Kaplan Rosandra N. , Yohe Marielle E. , Gross Andrea M. , Derdak Joanne , Lei Haiyan , Pan Alexander , Dombi Eva , Palacio-Yance Isabel , Herrera Kailey R. , Miettinen Markku M. , Chen Helen X. , Steinberg Seth M. , Helman Lee J. , Mascarenhas Leo , Widemann Brigitte C. , Navid Fariba , Shern Jack F. , Heske Christine M.
Published: July 2023

Tumor fractions from plasma cfDNA.
Supplementary Table S3 from Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
Authors: Akshintala Srivandana , Sundby R. Taylor , Bernstein Donna , Glod John W. , Kaplan Rosandra N. , Yohe Marielle E. , Gross Andrea M. , Derdak Joanne , Lei Haiyan , Pan Alexander , Dombi Eva , Palacio-Yance Isabel , Herrera Kailey R. , Miettinen Markku M. , Chen Helen X. , Steinberg Seth M. , Helman Lee J. , Mascarenhas Leo , Widemann Brigitte C. , Navid Fariba , Shern Jack F. , Heske Christine M.
Published: July 2023

Adverse events possibly probably or definitely related to dasatinib across all 28 cycles (maximum grade per patient)
Supplementary Method S1 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Methods
Supplementary Figure S1 from Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
Authors: Akshintala Srivandana , Sundby R. Taylor , Bernstein Donna , Glod John W. , Kaplan Rosandra N. , Yohe Marielle E. , Gross Andrea M. , Derdak Joanne , Lei Haiyan , Pan Alexander , Dombi Eva , Palacio-Yance Isabel , Herrera Kailey R. , Miettinen Markku M. , Chen Helen X. , Steinberg Seth M. , Helman Lee J. , Mascarenhas Leo , Widemann Brigitte C. , Navid Fariba , Shern Jack F. , Heske Christine M.
Published: July 2023

Progression-free survival for full cohort of patients (A) and by dose level (B).
Supplementary Figure S8 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S8. Single cell RNA-sequencing of whole blood treated with 0.2 μg/mL CD20-TCB was performed using the BD Rhapsody platform.
Supplementary Appendix S1 from Phase I trial of Ganitumab plus Dasatinib to Cotarget the Insulin-Like Growth Factor 1 Receptor and Src Family Kinase YES in Rhabdomyosarcoma
Authors: Akshintala Srivandana , Sundby R. Taylor , Bernstein Donna , Glod John W. , Kaplan Rosandra N. , Yohe Marielle E. , Gross Andrea M. , Derdak Joanne , Lei Haiyan , Pan Alexander , Dombi Eva , Palacio-Yance Isabel , Herrera Kailey R. , Miettinen Markku M. , Chen Helen X. , Steinberg Seth M. , Helman Lee J. , Mascarenhas Leo , Widemann Brigitte C. , Navid Fariba , Shern Jack F. , Heske Christine M.
Published: July 2023

Supplemental Protocol Information. A: Study Eligibility; B: Dasatinib dosing nomogram; C: Dasatinib dose modifications
Supplementary Figure S2 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S2. Proportions of T cells, monocytes and neutrophils in human whole blood after treatment with 0.2 μg/mL CD20-TCB
Supplementary Figure S10 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S10. Single cell RNA-sequencing of whole blood treated with 0.2 μg/mL CD20-TCB was performed using the BD Rhapsody platform
Supplementary Figure S1 from Dissecting the Mechanisms Underlying the Cytokine Release Syndrome (CRS) Mediated by T-Cell Bispecific Antibodies
Authors: Leclercq-Cohen Gabrielle , Steinhoff Nathalie , Albertí Servera Llucia , Nassiri Sina , Danilin Sabrina , Piccione Emily , Yángüez Emilio , Hüsser Tamara , Herter Sylvia , Schmeing Stephan , Gerber Petra , Schwalie Petra , Sam Johannes , Briner Stefanie , Jenni Sylvia , Bianchi Roberta , Biehl Marlene , Cremasco Floriana , Apostolopoulou Katerina , Haegel Hélène , Klein Christian , Umaña Pablo , Bacac Marina
Published: July 2023

Supplementary Figure S1. Levels of cytokines were measured by Luminex in serum from whole blood assay with CD20-TCB. 1 donor.
Supplementary Data 1 from Clinical and Genomic Characteristics of Patients with Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer Following Progression on Cyclin-Dependent Kinase 4 and 6 Inhibitors
Authors: Rao Xi , Chen Yongmei , Beyrer Julie , Nash Smyth Emily , Morato Guimaraes Claudia , Litchfield Lacey M. , Bowman Lee , Lawrence Garreth W. , Aggarwal Amit , Andre Fabrice
Published: July 2023

Supplementary material
Supplementary Data from ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types
Authors: Chüeh Anderly C. , Tse Janson W.T. , Dickinson Michael , Ioannidis Paul , Jenkins Laura , Togel Lars , Tan BeeShin , Luk Ian , Davalos-Salas Mercedes , Nightingale Rebecca , Thompson Matthew R. , Williams Bryan R.G. , Lessene Guillaume , Lee Erinna F. , Fairlie Walter D. , Dhillon Amardeep S. , Mariadason John M.
Published: July 2023

Supplementary Data from ATF3 Repression of BCL-XL Determines Apoptotic Sensitivity to HDAC Inhibitors across Tumor Types
Data from Clinical and Genomic Characteristics of Patients with Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer Following Progression on Cyclin-Dependent Kinase 4 and 6 Inhibitors
Authors: Rao Xi , Chen Yongmei , Beyrer Julie , Nash Smyth Emily , Morato Guimaraes Claudia , Litchfield Lacey M. , Bowman Lee , Lawrence Garreth W. , Aggarwal Amit , Andre Fabrice
Published: July 2023

AbstractPurpose:
We explored the clinical and genomic characteristics of hormone receptor–positive (HR+), HER2-negative (HER2−) metastatic breast cancer (MBC) after progression on cyclin-dependent kinase 4 and 6 inhibitors (CDK4 and 6i) ± endocrine therapy (ET) to understand potential resistance mechanisms that may aid in identifying treatment options.
Patients and Methods:
Patients in the United States with HR+, HER2− MBC had tumor biopsies collected from a metastatic site during routine care following progression on a CDK4 and 6i ± ET (CohortPost) or prior to initiating CDK4 and 6i treatment (CohortPre) and analyzed using a targeted mutation panel and RNA-sequencing. Clinical and genomic characteristics were described.
Results:
The mean age at MBC diagnosis was 59 years in CohortPre (n = 133) and 56 years in CohortPost (n = 223); 14% and 45% of patients had prior chemotherapy/ET, and 35% and 26% had de novo stage IV MBC, respectively. The most common biopsy site was liver (CohortPre, 23%; CohortPost, 56%). CohortPost had significantly higher tumor mutational burden (TMB; median 3.16 vs. 1.67 Mut/Mb, P < 0.0001), ESR1 alteration frequency (mutations: 37% vs. 10%, FDR < 0.0001; fusions: 9% vs. 2%, P = 0.0176), and higher copy-number amplification of genes on chr12q15, including MDM2, FRS2, and YEATS4 versus patients in the CohortPre group. In addition, CDK4 copy-number gain on chr12q13 was significantly higher in CohortPost versus CohortPre (27% vs. 11%, P = 0.0005).
Conclusions:
Distinct mechanisms potentially associated with resistance to CDK4 and 6i ± ET, including alterations in ESR1 and amplification of chr12q15 and CDK4 copy-number gain, were identified.
Diagnostic Performance and Safety of a Novel Ferumoxytol-Enhanced Coronary Magnetic Resonance Angiography
Authors: Dong Zhou , Si Guangxiang , Zhu Xiaomei , Li Chen , Hua Rui , Teng Jianzhen , Zhang Wenhao , Xu Lulu , Qian Wen , Liu Bo , Wang Jun , Wang Tong , Tang Yingdan , Zhao Yang , Gong Xiaoxuan , Tao Zhiwen , Xu Zhihui , Li Yong , Chen Bo , Kong Xiangqing , Xu Yi , Gu Ning , Li Chunjian
Published: July 2023

BACKGROUND:

Currently, noninvasive arteriography for the diagnosis of coronary artery disease is clinically limited to the computed tomography scanning, where patients have to be exposed to the radiation and risks associated with iodinated contrast. We aimed to investigate the diagnostic performance and safety of a novel ferumoxytol-enhanced coronary magnetic resonance angiography (CMRA) in patients with suspected coronary artery disease.

METHODS:

Thirty patients, 19 males, with a median age of 63 years old, and 17 with renal insufficiency, who were scheduled for invasive coronary angiography, were enrolled. Ferumoxytol was administered intravenously with a dose of 3 mg/kg during CMRA. Images were acquired with an ECG-triggered, navigator-gated, inversion recovery-prepared 3D fast low-angle shot sequence, and the image quality was assessed by a 4-point scale. Eighteen-segment coronary artery model was adopted to evaluate the visibility of the coronary arteries, and the image quality and stenosis were evaluated in nine segments. The diagnostic performance of CMRA is described as sensitivity, specificity, positive and negative predictive values, and accuracy with the invasive coronary angiography results as reference. The patients’ vital signs were monitored during CMRA, and their hepatic and renal functions were followed up for 3 months to evaluate the safety of ferumoxytol.

RESULTS:

Two hundred fifty-two of the 270 study segments were identified by CMRA, and their quality score reached 3.6±0.7. Referring to the invasive coronary angiography results, the sensitivity, specificity, positive predictive value, negative predictive value, and accuracy of ferumoxytol-enhanced CMRA reached 100.0%, 66.7%, 92.3%, 100.0%, and 93.3% respectively in patient-based analysis; 91.4%, 90.9%, 86.5%, 94.3%, and 91.1%, respectively in vessel-based analysis; and 92.3%, 96.7%, 83.7%, 98.6%, and 96.0%, respectively in segment-based analysis. No ferumoxytol-related adverse event was observed during the 3-month follow-up.

CONCLUSIONS:

Ferumoxytol-enhanced CMRA demonstrated good diagnostic performance and excellent safety in the diagnosis of significant coronary stenosis, providing an alternative to coronary computed tomography angiography for the diagnosis of coronary artery disease.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT05032937.