bluuebunny/crossref_metadata_2025 huggingface dataset:
Ricci Solitons and the Spacetime of General Relativity
Authors: Ahsan Zafar
Published: September 2022

The vector fields associated with Ricci flow and Ricci solitons in Riemann manifold has been studied and the correspondence between these vector fields and symmetries of spacetime manifold of general relativity has been established. The relationships between the symmetries of Petrov type D and N pure radiation fields and Ricci solitons have been explored. The solitons corresponding to Schwarzschild solution and Reissner-Nordstrom spacetime have been obtained.
On LP-Sasakian Manifolds satisfying Certain Curvature Tensors
Authors: Prasad B , Yadav R.P S
Published: September 2022

The object of the present paper is to study some curvature condition on LPSasakian manifolds which satisfy P.W _2 = 0, W_2. W_2 = 0, L. W_2 = 0, W_2.L = 0, W_2.W_2 = 0 and W_2. R = 0
Finslerian Subspaces given by Generalized Conformal β−Change
Authors: Kumbar Mallikarjun , Narasimhamurthy S K
Published: September 2022

In the present paper, we study Finslerian subspace F^m of F^n and another Finslerian subspace F¯^m of the F¯^n subjected to the generalized conformal βchange is totally geodesic and totally h-autoparallel
A study on conformal Ricci soliton on almost C(α)-manifolds admitting W2 curvature tensor
Authors: Vidyavathi K R , Bagewadi C S
Published: September 2022

We study the conformal Ricci solitons on C(α)-manifolds. It is shown that if a C(α)- manifold with a conformal Ricci soliton satisfies certain curvature conditions, then the manifold is either an Einstein manifold or η-Einstein manifold.
Some Properties of CR-Submanifolds of a Kenmotsu Manifold
Authors: Almia Priyanka , Upreti J
Published: September 2022

The purpose of the present paper is to initiate the study of CR-submanifolds of a Kenmotsu manifold and obtain some properties. The conditions under which the distributions required by CR- submanifolds to be integrable, are obtained. D-parallel normal section of CR-submanifolds have been studied.
On the Hypersurfaces of Almost r- Contact Manifold
Authors: Narain Dhruwa , Srivastava Sachin Kumar
Published: September 2022

In the present paper , we have studied the structure induced on hypersurfaces of almost r-contact Riemannian manifold and proved that on this hypersurfaces with (φ,ξα ,ηα) connection if 1- form ῆα , α ε (r) is covariant almost analytic vector field
Absolute Nevanlinna Summability of a Series associated with the Derived Fourier Series
Authors: Chandra Sachis , Babu Suresh
Published: September 2022

In this Paper we have proved a theorem on absolute Nevanlinna of a series associated with the derived Fourier series, which generalizes various known result.
ELECTRONIC, OPTICAL AND MECHANICAL PROPERTIES OF GRAPHENE/MoS2 NANOCOMPOSITE
Authors:   Le Quy Don Technical University, Nguyen Van Chuong
Published: September 2022

In this work, we construct an ultrathin graphene/MoS2 nanocomposite and investigate systematically its electronic, optical and mechanical properties using first-principles calculations based on density functional theory. Our results show that graphene and MoS2 layers in their corresponding graphene/MoS2 nanocomposite are bonded mainly via the weak van der Waals forces, which are not enough to modify the intrinsic properties of the constituent monolayers, thus the electronic properties are well preserved. Moreover, the optical and mechanical properties of the graphene/MoS2 nanocomposite are enhanced as compared with those of individual constituent graphene and MoS2 monolayers. The maximum of absorption intensity can reach up to 2.5×105 cm-1. Moreover, the Young’s modulus of nanocomposite increases up to 487.2 N/m2. These findings demonstrate that the formation of the graphene/MoS2 nanocomposite could effectively be used to enhance the electronic, optical and mechanical performances of both graphene and MoS2 monolayers.
An efficient algorithm to extract Skyline itemsets
Authors:   Ho Chi Minh City University of Food Industry. Ho Chi Minh, Vietnam, Thi Thanh Thuy NGUYEN , Thien Ly MANH ,   Ho Chi Minh City University of Food Industry. Ho Chi Minh, Vietnam, Van Le NGUYEN ,   Ho Chi Minh City University of Food Industry. Ho Chi Minh, Vietnam, Van Vinh VU ,   Ho Chi Minh City University of Food Industry. Ho Chi Minh, Vietnam
Published: September 2022

Mining skyline frequent-utility patterns (SFUPs) is the discovery of itemsets that surpasses all other itemsets in both frequency and utility in transactional database. The discovery of these itemsets is important for managers in finding items that customers buy many times and bring high profits for businesses. In recent years, there have been many algorithms proposed to exploit skyline frequent-utility patterns, of which SKYFUP-D is the most efficient algorithm. However, this algorithm still has limitations in both execution time and storage space. In this paper, we propose an effective method to exploit SFUPs faster by applying pruning strategies to reduce the number of candidates. Experimental results show that the execution time and storage space are significantly improved.
Study on hot water treatment methods to germination ability and effect of substrate on growth of Plukenetia volubilis L. in nursery period in Nghe An Province
Authors:   Institute of Agriculture and Natural Resources, Vinh University, Vietnam, Thi Thu Hien PHAN , Van Hoan NGUYEN ,   Institute of Agriculture and Natural Resources, Vinh University, Vietnam, Thi Mai Vi NGO ,   Institute of Agriculture and Natural Resources, Vinh University, Vietnam, Ngoc Toan TRAN ,   Institute of Agriculture and Natural Resources, Vinh University, Vietnam
Published: September 2022

This study was conducted to improve the germination ability and to determine a suitable substrate for Sachi seedlings (P. volubilis L.) at the nursery stage. The experiment was conducted in completed randomized design with three replicates. The result showed that: Treatment hot water effect to germination ability of P. volubilis seed, with 2 boiled water in 3 cool water (equivalent 52oC) gave highest germination seed number and rate. Immersion seed of P. volubilis in 2 boiled water in 3 cool water (equivalent 52oC) in 16 hours was the best at germination (equivalent 16.3 seeds and 41.5%). Mixed substrate with 3 soil : 1 farmyard manure plus 0.5 kg Que Lam compost indicated the most rapidly growth plant with 27.32 cm plant height, 7.98 leafs per plant and the shortest nursery period (only 31 days).
Fabrication method and experiment mechanical properties of light-weight concrete using Keramzit aggregates
Authors:   Civil Engineering Department, Vinh University, Vietnam, Xuan Hieu NGUYEN , Xuan Hung VU ,   Civil Engineering Department, Vinh University, Vietnam
Published: September 2022

Light-weight concrete is often used in structures for soundproof and insulation. The determination of mechanical properties of this material is an important issue in the bearing capacity assessment, durability, and construction cost. This paper presents a procedure for determining mechanical properties of the light-weight concrete using Keramzit aggregates based on a series of experiments. The difference between mechanical properties of the light-weight concrete and normal concrete with the same compressive strength has identified. A relationship between the compressive strength and the volumetric mass density of the light-weight concrete has been proposed. Moreover, other mechanical properties of the compressive strength at 28 days of the light-weight concrete are investigated, and a comparison with those of previous studies is also conducted in this work.
On an extension of the Borel-Cantelli lemma for double arrays of dependent events
Authors:   Natural Pedagogical Institute, Vinh University, Vietnam, Thi Ngoc Anh NGUYEN , Thi Binh NGUYEN ,   Natural Pedagogical Institute, Vinh University, Vietnam, Van Thanh LE ,   Natural Pedagogical Institute, Vinh University, Vietnam, Thi Phuong Thao NGUYEN ,   Natural Pedagogical Institute, Vinh University, Vietnam
Published: September 2022

In this paper, we present an extension of the Borel–Cantelli lemma for double arrays of dependent events. From our main result, we obtain Theorem 2.1 of Petrov [Statistics and Probability Letters, 2002] and the Borel–Cantelli lemma for double arrays of pairwise independent events as special cases.
Some issues on m’nong epics and the relationship between ot ndrong and the communal life of the M'nong people
Authors:   Tay Nguyen University, Buon Ma Thuot City, Dak Lak Province, Van Thinh TRIEU
Published: September 2022

The epic of M’nong (ot ndrong) is a cultural heritage of the M’nong ethnic group as well as that of the Vietnamese nation. In this article, the M’nong epic is studied from two perspectives: first, in the performing context, ot ndrong cannnot be performed without the epic rhapsodes; second, in the relationship with the community, ot ndrong is associated with the customs, beliefs and cultural identity of the M’nong ethnic group. Ethnographic fieldwork method is applied in this study, combined with data analysis. The contribution of the article is to indicate the specific features of the epic rhapsodes in M'nong community, and to interpret the communal culture hidden in M’nong people. The study therefore raises a voice of preserving ot ndrong in particular as well as the M’nong cultural values in general.
Assesment of typical characteristics and revival selection of the special nep Rong rice cultivar in Yen Thanh District, Nghe An Province.
Authors:   Institute of Agriculture and Resources Management, Vinh University, Tai Toàn NGUYEN , Van Hieu NGUYEN , Van Dan PHAM , Van Hung LUONG ,   Institute of Agriculture and Resources Management, Vinh University, Van Khanh LE ,   Nghe An Center for Advanced Application of Science and Technology, Van Linh PHAN ,   INTAD Co.Ltd., Tuan Anh NGUYEN ,   INTAD Co.Ltd.
Published: September 2022

Nep Rong is a special sticky rice cultivar cultivated in the Nghe Tinh region where Yen Thanh district has been considered as the native land of this cultivar. This study aims to select and restore Nep Rong to serve the requirement of production. The process of evaluating and revival selecting was carried out from 2017 to 2020 according to the standard 10TCN 395: 1999, and then replaced by the National Standard TCVN 12181: 2018 on the process of seed producing in self-pollinated crop. As a result, the “Table of characteristic traits of the Nep Rong rice cultivar” was established as a basis for revival selecting. In the first crop, 150 lines of G0 have been selected with the characteristic traits of the dragon sticky rice cultivar. In the second crop, 30 lines G1 were selected out of a total of 150 G0 lines that have the typical characteristics and have scent of aromatic from 4.38 points (scented) to 6.42 points (typical scented). These 30 lines G2 were grown and characterized for uniformity and 11 of them were selected. The seeds of these 4 of 11 selected lines were mixed and 55 kg of breeder seeds was obtained and certified
Research and development of traps for harmful insects to serve clean agriculture production
Authors:   University of Information and Communication Technology, Thai Nguyen University, Van Toan DO , Thi Thanh Thuy NGUYEN ,   University of Information and Communication Technology, Thai Nguyen University
Published: September 2022

The production of vegetables and fruits is greatly affected by harmful insects, so vegetable growers frequently must use pesticides. If these chemicals are used improperly, residues will affect the environment, which has significant impacts on people health causing unsafety for both producers and consumers. Therefore, it is necessary to research and manufacture traps for harmful insects to minimize insects’ harmful effects, and to reduce and move towards no use of pesticides. This study based on the biological properties of some harmful insects to propose one type of insect trap with effectiveness and safety for users.
Broadcast routing in wireless sensor network
Authors:   Faculty of Engineering - Technology, Ha Tinh University, Vietnam, Quoc Dung NGUYEN , Thi Viet NGUYEN ,   Institute of Electronics - Technology, Xiamen University, China
Published: September 2022

The wireless sensor networks are interested in research and widely applied in some fields such as industry, agriculture, medical, military, and transportation. Broadcasting is an important application of wireless sensor networks. This paper has analyzed, classified and evaluated some broadcast approaches in wireless sensor networks. Based on the analysis and survey of broadcast routing protocols, the paper has built a simulation scenario in the NS2 network simulation to evaluate and compare the performance of some protocols such as EMBA, CEB and EENWB. These results are the theoretical basis for research and proposal to improve the efficiency of wireless sensor networks.
Competences to perform the bridge role between students and employers of academic advisors at technical pedagogical universities
Authors:   Vinh University of Technology Education, Thi Ngoc Lan PHAM
Published: September 2022

Student career consulting is increasingly diverse and demanding. Academic advisors play an important role in the effectiveness of consultancy. This paper aims to examine the competences that academic advisors need to act as a bridge between students and employers. Based on the conceptual framework of “bridge role” and a practical basis at the University of Technical Pedagogy, this study applies analytical and synthetic methods to determine the competences that academic advisors need to acquire. Those include vocational competence; natural conversational capacity; ability of recruitment needs assessment; cooperation capacity; creativity capacity; and advisory and forecasting capacity.
The role of social networks in enrollment strategy of universities in Vietnam
Authors:   Academic Affairs Office, National Economics University, Thanh Binh NGUYEN , Dang Khoa NGUYEN ,   Faculty of Statistics, National Economics University, Tran Ngoc Anh PHAM ,   School of Advanced Education Programs, National Economics University
Published: September 2022

It is increasingly vital for universities to compete more and more to attract students with better input quality. Enrollment consultation has become an important part of the enrollment strategy of higher education institutions. In Vietnam, robust development of information technology infrastructure, declining prices of services and equipment and increasingly widespread applications of social networking have resulted in the growing role social media in communication and enrollment strategy of universities. This study compares the change in social media usage, specifically, videos on the social network facebook, as an important communication and enrollment promotion tool of 29 public universities in Hanoi in 2019 and 2020. The findings show that there is a strong growth in both quantity and quality of enrollment promotion videos over the past 2 years. The study also shows that fluctuations in the number of videos, video length, and enrolment quotas had an impact on the number of views of promotion videos on social networks. There are some implications that university managers might consider: enhancing reputation by taking various approaches, describing the program structure, explaining relevant skills and knowledge that learners may have, describing student life examples. University should also be aware of the benefits and importance of alumni and current students as well as university staff. University marketing managers can plan and execute effective marketing strategies at various levels to reach potential students, to engage with them through social networks and finally turn these interactions into applications.
Pengaruh Penilaian Prestasi Kerja Terhadap Promosi Jabatan Pada PT. Bank Rakyat Indonesia (persero) Tbk. Kantor Wilayah Makassar
Authors: Saeni Nuraeni
Published: September 2022

Studi ini bertujuan untuk menganalisis pengaruh Penilaian Prestasi Kerja, dimana prestasi kerja diperinci atas: Kedisiplinan, Kepribadian, Kecakapan dan tanggung jawab terhadap promosi jabatan pada PT.Bank Rakyat Indonesia (persero) Tbk. Kantor Wilayah Makassar. Adapun metode analisis yang digunakan untuk mengukur pengaruh penilaian prestasi kerja untuk meraih promosi jabatan adalah pengukuran skala likert melalui koesioner dengan menggunakan metode analisis regresi linear berganda serta uji instrument dan uji asumsi klasik dengan menggunakan alat bantu program SPSS. Populasi dalam penelitian ini adalah seluruh karyawan PT. Bank Rakyat Indonesia (Persero) Tbk. Kantor Wilayah Makassar yang berjumlah 122 orang. Teknik pengambilan sampel yang digunakan adalah metode solvin. Teknik pengumpulan data salah satunya dengan kuesioner. Promosi jabatan merupakan variabel dependent (Y), sedangkan variabel independent adalah kedisiplinan (X1), kepribadian (X2), kecakapan (X3), tanggung Jawab (X4). Hasil ananlisis penilaian prestasi kerja karyawan menunjukkan bahwa terdapat pengaruh pada variabel kedisiplinan, kepribadian, kecakapan dan tanggung jawab secara simultan berpengaruh signifikan positif terhadap promosi jabatan.
Das Recht der Spielervermittlung im deutschen Berufsfußball
Authors: Knauer Sven
Published: September 2022

This work comprehensively analyzes and evaluates the current legal situation regarding player intermediation in German professional football. It examines the legislation of the DFB and its compatibility with the German law on general terms and conditions and European law. Based on this, the framework conditions under civil law, considering the unique features of association law and the Legal Services Act, are analyzed comprehensively. One focus is on identifying and evaluating the risks under civil law and the options for avoiding them from the perspective of all parties involved in the transfer. The work is therefore also suitable as an aid in contract drafting for intermediaries, clubs, and players.
Comparing Executive Function Between Surgically and Interventionally Treated Children with Congenital Heart Disease
Authors: Mani Arash , Nasiri Maryam , Amoozgar Hamid , Amirghofran Ahmad Ali , Nejati Vahid
Published: September 2022

Background: Improving surgical and interventional modalities for treating congenital heart disease has increased these children’s life expectancy, leading to increased cognitive and behavioral problems. Objectives: This study compared executive function between surgically and interventionally treated congenital heart disease children and their age-matched controls. Methods: In this retrospective cross-sectional study, we enrolled 30 children treated with surgery, 30 interventionally treated patients, and 30 healthy controls. These participants were compared in the executive function domains by the Stroop test, trail making test, cancellation test, visual and auditory memory span test, and behavioral problems using the parental form of strengths and difficulties questionnaire. Results: Executive function in memory span and sustained attention was lower in the surgical group than in the intervention group (P < 0.05). Both groups had lower flexibility, memory recall, simple and complex working memory, visual attention, and simple and complex selective attention performance (P < 0.05). The effect of behavioral problems on daily life was higher in surgical patients than in the intervention group (P < 0.0001). Both groups of patients had higher emotional, conduct, and communication problems than the control group (P < 0.0001). Conclusions: Interventionally treated patients had better performance than surgically treated patients. Regardless of disease severity or treatment, patients with congenital heart disease had poor performance than normal subjects and suffered from behavioral disorders affecting their daily lives. Therefore, it is essential to include diagnostic and therapeutic interventions for treating these patients’ executive function and behavioral problems.
Anatomical Variations of the Mandibular Canal and Mental Foramen in Full Edentulous Iranian Subpopulation: A Cone-Beam Computed Tomographic Study
Authors: Safi Yaser , Amid Reza , Kadkhodazadeh Mahdi , Rezaei Sadaf , Kazeminia Marjan
Published: September 2022

Background: This study sought to determine the anatomical variations of the mental foramen (MF) and the mandibular canal (MC) in the full edentulous Iranian subpopulation using cone-beam computed tomography (CBCT). These variations can have significant clinical implications in dental implant surgery. Methods: This descriptive cross-sectional study evaluated the mandible CBCT scans of 384 completely edentulous patients that required dental implant treatment. The CBCT scans were retrieved from four radiology clinics in Tehran, Iran, using quota sampling. The reconstructed images were evaluated to determine the dimensions and position of the MC and its cortication at the site of the mandibular first molar, the branching of the MC, the existence of the anterior loop of the mental nerve, and anatomical variations of the MF. The correlations of variables with age and gender were analyzed using the independent t-test, chi-square test, and analysis of variance based on the type of the variable. Results: The cortication of the MC at the site of the mandibular first molar was present in 72.9% of the cases and was significantly more common in male patients (P = 0.0001). Bifid mandibular canal, accessory MF, and anterior loop of mental nerve were present in 9.9%, 65%, and 54.7% of the samples, respectively, and they had no significant correlation with age/gender. The mean MC diameter, the mean MF height, and the mean distance from the inferior border of the mandible to the center of MF were all significantly higher in male patients (P < 0.05). The mean distance between the MC and the buccal and lingual cortical plates had no correlation with age/gender. The mean height between the superior part of the MC and the alveolar crest was significantly lower in female patients and those within the age range of 71 - 95 years (P < 0.05). The MC opened in the MF superiorly in 40.1% of the patients with no significant correlation with age/gender. Conclusions: Anatomical variations in the course and location of the MC and MF necessitate the precise assessment of the edentulous ridge by CBCT prior to the placement of implants.
There Is Something to the Authority Thesis
Authors: Winokur Benjamin ,   Philosophy Documentation Center
Published: September 2022

Many philosophers accept an ‘Authority Thesis’ according to which self-ascriptions of one’s current mental states ordinarily are or ought to be met with a distinctive presumptive of truth. Recently, however, Wolfgang Barz (2018) has argued that there is no adequately specified Authority Thesis. This, he argues, is because available specifications are either (1) philosophically puzzling but implausible, or (2) plausible but philosophically unpuzzling. I argue that there are several plausible and philosophically puzzling specifications of the Authority Thesis.
Interval Appendectomy Specimens
Authors: Mostyka Maria , Yantiss Rhonda K. , Chen Zhengming , Tseng-Chen Yao
Published: September 2022

Context.—

Patients with perforated appendicitis are often managed with antibiotic therapy followed by a delayed appendectomy. Histologic features of such specimens have been incompletely described, especially in the recent literature.

Objective.—

To describe the histomorphology of interval appendicitis with a focus on features that could mimic important conditions, such as infections, Crohn disease, and mucinous neoplasms.

Design.—

Histologic evaluation of 100 interval appendectomy specimens with clinical and radiologic correlation.

Results.—

A total of 54 of the 100 patients (54%) had radiologic evidence of appendiceal perforation, and 97% were treated with intravenous and/or oral antibiotic therapy prior to appendectomy. Percutaneous drains were placed in 34 cases (34%). Common histologic findings included mural eosinophilic infiltration (54%), periappendiceal fibrosis (54%), and xanthogranulomatous inflammation (31%). Periappendiceal fibrosis was frequent among patients with radiologic evidence of perforation. Nine cases (9%) featured pulse granulomata associated with fecal material. Epithelioid granulomata were detected in 6% of cases and were confined to mucosal lymphoid follicles in all cases. Only 4 of these were accompanied by mural lymphoid aggregates that raised the possibility of Crohn disease. Changes mimicking mucinous neoplasms were more common: 14% of cases (14 of 100) displayed goblet cell hyperplasia, 15% (15 of 100) contained diverticula, and 16% (16 of 100) showed mural or periappendiceal mucin pools.

Conclusions.—

Although interval appendectomy specimens occasionally contain inflammatory infiltrates that mimic infections and/or Crohn disease, changes that can be confused with mucinous neoplasms are more frequently encountered.
Extract of Morinda lucida leaf rescues hypoglycaemic and dyslipidaemic conditions in Plasmodium berghei-infected mice
Authors: Abdulkareem Adam , Babamale Abdulkareem , Anifowoshe Abass , Opeyemi Olufunke , Oloriegbe Nusirat , Adamolekun Comfort , Adetula Samson , Ala Adeola
Published: September 2022

Increasing drug resistance is a great threat to malaria control. Therefore, a continuous investigation into alternative therapy to mitigate malaria-associated damages is important. In this study, we investigated the anti-hypoglycaemic and anti-hyperlipidaemic effects of aqueous extract of Morinda lucida leaf in Plasmodium berghei-infected mice. Twenty-five mice were randomly grouped into five: Uninfected, infected-untreated, chloroquine (20 mg/kg, per oral), and extract-treated (400 mg/kg and 800 mg/kg, respectively, per oral) groups. Fasting blood glucose was measured before parasite inoculation and after the last treatment. Blood was collected for lipid profile assay at the end of the 4-day treatment. Our results revealed that both chloroquine and the extract lowered parasite growth (p <0.05), while chloroquine and 400 mg/kg of the extract improved blood glucose in Plasmodium berghei-infection. More so, all the treated groups showed attenuated Plasmodium berghei-induced dyslipidaemia, with 400 mg/kg of the extract exhibiting better efficacy. Therefore, this study suggests that Morinda lucida leaf extract can be harnessed as a therapeutic regimen for improved malaria treatments and associated complications. Further study is recommended to elucidate the mechanism of anti-hypoglycaemic and anti-hyperlipidaemic activities of the extract and the possible bioactive compound(s) involved.
Groundwater flow numerical model to evaluate the water mass balance and flow patterns in Groundwater Circulation Wells (GCW) with varying aquifer parameters
Authors: Toscani Luca , Stefania Gennaro Alberto , Masut Edoardo , Prieto Melissa , Legnani Anna , Gigliuto Andrea , Ferioli Luca , Battaglia Alessandro
Published: September 2022

Groundwater Circulation Wells (GCW) can be an effective in-situ remediation option allowing high mass recovery of contaminants in cases where contamination hotspots are located in saturated soil having low hydraulic conductivity. Traditional treatment options such as Pump&Treat, Air Sparging (AS)/Soil Vapor Extraction (SVE) and Multi Phase Extraction (MPE) typically require long operation times and significant costs for long-term plume management. GCWs induce meaningful changes in the groundwater flow introducing vertical flows both downward and upward, generating a “circulation cell”, which facilitates contaminant desorption from the soil. This study aims to understand the effects of a GCW on an aquifer in terms of both groundwater flow directions and water balance. A groundwater numerical model was built using MODFLOW-2005 to simulate the effect of the hydraulic parameters of the aquifer on the hydraulic circulation pattern of the GCW. The use of particle tracking simulated by MODPATH 7 showed the circulation cells and the impact on groundwater directions induced by different configurations of hydraulic parameters. The water flowing into the cell comes from both the injection well and the surrounding aquifer and the model shows how the hydraulic parameters of the aquifer, in particular the horizontal and vertical hydraulic conductivity, have a paramount influence in determining the shape and dimension of the circulation cell. A water mass balance analysis was carried out. It allowed to predict the groundwater flows exchanges between the GCW system and the surrounding aquifer, and to verify the sensitivity of the water budget to specific aquifer parameters. The results of this study are useful for further understanding the hydraulics of a GCW remediation system in order to support the design and to predict its performance.
The C. elegans gonadal sheath Sh1 cells extend asymmetrically over a differentiating germ cell population in the proliferative zone
Authors: Li Xin , Singh Noor , Miller Camille , Washington India , Sosseh Bintou , Gordon Kacy Lynn
Published: September 2022

The Caenorhabditis elegans adult hermaphrodite germline is surrounded by a thin tube formed by somatic sheath cells that support germ cells as they mature from the stem-like mitotic state through meiosis, gametogenesis, and ovulation. Recently, we discovered that the distal Sh1 sheath cells associate with mitotic germ cells as they exit the niche Gordon et al., 2020. Here, we report that these sheath-associated germ cells differentiate first in animals with temperature-sensitive mutations affecting germ cell state, and stem-like germ cells are maintained distal to the Sh1 boundary. We analyze several markers of the distal sheath, which is best visualized with endogenously tagged membrane proteins, as overexpressed fluorescent proteins fail to localize to distal membrane processes and can cause gonad morphology defects. However, such reagents with highly variable expression can be used to determine the relative positions of the two Sh1 cells, one of which often extends further distal than the other.
Neural synchronization is strongest to the spectral flux of slow music and depends on familiarity and beat salience
Authors: Weineck Kristin , Wen Olivia Xin , Henry Molly J
Published: September 2022

Neural activity in the auditory system synchronizes to sound rhythms, and brain–environment synchronization is thought to be fundamental to successful auditory perception. Sound rhythms are often operationalized in terms of the sound’s amplitude envelope. We hypothesized that – especially for music – the envelope might not best capture the complex spectro-temporal fluctuations that give rise to beat perception and synchronized neural activity. This study investigated (1) neural synchronization to different musical features, (2) tempo-dependence of neural synchronization, and (3) dependence of synchronization on familiarity, enjoyment, and ease of beat perception. In this electroencephalography study, 37 human participants listened to tempo-modulated music (1–4 Hz). Independent of whether the analysis approach was based on temporal response functions (TRFs) or reliable components analysis (RCA), the spectral flux of music – as opposed to the amplitude envelope – evoked strongest neural synchronization. Moreover, music with slower beat rates, high familiarity, and easy-to-perceive beats elicited the strongest neural response. Our results demonstrate the importance of spectro-temporal fluctuations in music for driving neural synchronization, and highlight its sensitivity to musical tempo, familiarity, and beat salience.
The number of cytokinesis nodes in mitotic fission yeast scales with cell size
Authors: Sayyad Wasim A , Pollard Thomas D
Published: September 2022

Cytokinesis nodes are assemblies of stoichiometric ratios of proteins associated with the plasma membrane, which serve as precursors for the contractile ring during cytokinesis by fission yeast. The total number of nodes is uncertain, because of the limitations of the methods used previously. Here, we used the ~140 nm resolution of Airyscan super-resolution microscopy to measure the fluorescence intensity of small, single cytokinesis nodes marked with Blt1-mEGFP in live fission yeast cells early in mitosis. The ratio of the total Blt1-mEGFP fluorescence in the broad band of cytokinesis nodes to the average fluorescence of a single node gives about 190 single cytokinesis nodes in wild-type fission yeast cells early in mitosis. Most, but not all of these nodes condense into a contractile ring. The number of cytokinesis nodes scales with cell size in four strains tested, although large diameter rga4Δ mutant cells form somewhat fewer cytokinesis nodes than expected from the overall trend. The Pom1 kinase restricts cytokinesis nodes from the ends of cells, but the surface density of Pom1 on the plasma membrane around the equators of cells is similar with a wide range of node numbers, so Pom1 does not control cytokinesis node number. However, when the concentrations of either kinase Pom1 or kinase Cdr2 were varied with the nmt1 promoter, the numbers of cytokinesis nodes increased above a baseline of about ~190 with the total cellular concentration of either kinase.
Live-cell imaging in human colonic monolayers reveals ERK waves limit the stem cell compartment to maintain epithelial homeostasis
Authors: Pond Kelvin W , Morris Julia M , Alkhimenok Olga , Varghese Reeba P , Cabel Carly R , Ellis Nathan A , Chakrabarti Jayati , Zavros Yana , Merchant Juanita L , Thorne Curtis A , Paek Andrew L
Published: September 2022

The establishment and maintenance of different cellular compartments in tissues is a universal requirement across all metazoans. Maintaining the correct ratio of cell types in time and space allows tissues to form patterned compartments and perform complex functions. Patterning is especially evident in the human colon, where tissue homeostasis is maintained by stem cells in crypt structures that balance proliferation and differentiation. Here, we developed a human 2D patient derived organoid screening platform to study tissue patterning and kinase pathway dynamics in single cells. Using this system, we discovered that waves of ERK signaling induced by apoptotic cells play a critical role in maintaining tissue patterning and homeostasis. If ERK is activated acutely across all cells instead of in wave-like patterns, then tissue patterning and stem cells are lost. Conversely, if ERK activity is inhibited, then stem cells become unrestricted and expand dramatically. This work demonstrates that the colonic epithelium requires coordinated ERK signaling dynamics to maintain patterning and tissue homeostasis. Our work reveals how ERK can antagonize stem cells while supporting cell replacement and the function of the gut.
Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography
Authors: John Juliane , Aurelius Oskar , Srinivas Vivek , Saura Patricia , Kim In-Sik , Bhowmick Asmit , Simon Philipp S , Dasgupta Medhanjali , Pham Cindy , Gul Sheraz , Sutherlin Kyle D , Aller Pierre , Butryn Agata , Orville Allen M , Cheah Mun Hon , Owada Shigeki , Tono Kensuke , Fuller Franklin D , Batyuk Alexander , Brewster Aaron S , Sauter Nicholas K , Yachandra Vittal K , Yano Junko , Kaila Ville RI , Kern Jan , Lebrette Hugo , Högbom Martin
Published: September 2022

Redox reactions are central to biochemistry and are both controlled by and induce protein structural changes. Here, we describe structural rearrangements and crosstalk within the Bacillus cereus ribonucleotide reductase R2b–NrdI complex, a di-metal carboxylate-flavoprotein system, as part of the mechanism generating the essential catalytic free radical of the enzyme. Femtosecond crystallography at an X-ray free electron laser was utilized to obtain structures at room temperature in defined redox states without suffering photoreduction. Together with density functional theory calculations, we show that the flavin is under steric strain in the R2b–NrdI protein complex, likely tuning its redox properties to promote superoxide generation. Moreover, a binding site in close vicinity to the expected flavin O2 interaction site is observed to be controlled by the redox state of the flavin and linked to the channel proposed to funnel the produced superoxide species from NrdI to the di-manganese site in protein R2b. These specific features are coupled to further structural changes around the R2b–NrdI interaction surface. The mechanistic implications for the control of reactive oxygen species and radical generation in protein R2b are discussed.
Memory persistence and differentiation into antibody-secreting cells accompanied by positive selection in longitudinal BCR repertoires
Authors: Mikelov Artem , Alekseeva Evgeniia I , Komech Ekaterina A , Staroverov Dmitry B , Turchaninova Maria A , Shugay Mikhail , Chudakov Dmitriy M , Bazykin Georgii A , Zvyagin Ivan V
Published: September 2022

The stability and plasticity of B cell-mediated immune memory ensures the ability to respond to the repeated challenges. We have analyzed the longitudinal dynamics of immunoglobulin heavy chain repertoires from memory B cells, plasmablasts, and plasma cells from the peripheral blood of generally healthy volunteers. We reveal a high degree of clonal persistence in individual memory B cell subsets, with inter-individual convergence in memory and antibody-secreting cells (ASCs). ASC clonotypes demonstrate clonal relatedness to memory B cells, and are transient in peripheral blood. We identify two clusters of expanded clonal lineages with differing prevalence of memory B cells, isotypes, and persistence. Phylogenetic analysis revealed signs of reactivation of persisting memory B cell-enriched clonal lineages, accompanied by new rounds of affinity maturation during proliferation and differentiation into ASCs. Negative selection contributes to both persisting and reactivated lineages, preserving the functionality and specificity of B cell receptors (BCRs) to protect against current and future pathogens.
High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened
Authors: Gonçalves Antunes Marina , Sanial Matthieu , Contremoulins Vincent , Carvalho Sandra , Plessis Anne , Becam Isabelle
Published: September 2022

The oncogenic G-protein-coupled receptor (GPCR) Smoothened (SMO) is a key transducer of the hedgehog (HH) morphogen, which plays an essential role in the patterning of epithelial structures. Here, we examine how HH controls SMO subcellular localization and activity in a polarized epithelium using the Drosophila wing imaginal disc as a model. We provide evidence that HH promotes the stabilization of SMO by switching its fate after endocytosis toward recycling. This effect involves the sequential and additive action of protein kinase A, casein kinase I, and the Fused (FU) kinase. Moreover, in the presence of very high levels of HH, the second effect of FU leads to the local enrichment of SMO in the most basal domain of the cell membrane. Together, these results link the morphogenetic effects of HH to the apico-basal distribution of SMO and provide a novel mechanism for the regulation of a GPCR.
¿Cómo comprende el discurso escrito el posthumano del s. XXI?
Authors:   Facultad de Comunicaciones y Artes, Universidad de Las Américas, Chatzikoumi Eirini
Published: September 2022

Según el posthumanismo crítico, el ser humano se constituye en relación y mutua influencia con los otros animales y las máquinas. A través de una severa crítica al humanismo, cuyo centro ha sido un ser humano prototípico, plantea una postura contraria a cualquier dualismo y postula la permeabilidad de lo humano, lo animal y lo tecnológico. Como los avances tecnológicos de las últimas décadas han sido vertiginosos, es legítimo preguntarse cómo se puede interpretar bajo esta mirada una de las facultades tradicionalmente consideradas como humanas por excelencia: el lenguaje. Concretamente, el presente trabajo se sitúa en el marco de la comprensión del discurso escrito y plantea la pregunta: ¿cómo comprende el discurso escrito el posthumano del s. XXI? Bajo el foco del posthumanismo, se presenta el contexto actual altamente digitalizado y los desafíos que este presenta para la comprensión de lectura. La revisión bibliográfica incluye una serie de hallazgos empíricos, que, interpretados con la mirada posthumanista crítica, permiten una primera caracterización de lo que es la comprensión del discurso escrito hoy en día. El tema presenta implicancias educativas de suma relevancia para las prácticas actuales y futuras, las cuales también se discuten al final del artículo.
Exchange Rate Regimes, Import Prices and Foreign Reserve Holdings in Africa
Authors: Umoru David , Obomeghie Muhammed Adamu , Eshemogie Kasim
Published: September 2022

In this study, we examined dynamic interaction between exchange rate regimes, import prices and foreign reserve holdings in developing countries. Monthly data for the study were obtained on five African countries from 1980M1 to 2020M12. Recognizing that our sample of nations may not be homogenous due to unobserved characteristics of the individual countries such as, economic size, or differences in financial strength, we modelled reserve holding following P-ARDL specifications of Pesaran, Shin & Smith (1995) which recognizes the MG and PMG modeling in error correction configurations. The Hausman test reveals that MG was more efficient compared to PMG. To check robustness of our MG estimates, we had an alternative GMM specification. The GMM estimation was also necessitated to overcome simultaneity biases and endogeneity problems that characterized OLS estimation of our P-ARDL model. Findings showed that exchange rate regime is a significant positive contributor to the volume of reserve holdings while import prices negatively influences reserve holdings. Relatively, study reveals negative contributions of cost of holding reserves, and inflation towards declining reserve holding in selected countries of Africa is highly significant in both SR and LR. Nevertheless, significant heterogeneity exists amongst countries as regards speed of adjustment following disturbances in SR reserve holding to LR convergence. Nigeria had the fastest speed of 61% compared to Angola, Kenya, South Africa, and Egypt with 49%, 20%, 50%, and 19% respectively. Differences in economic strength, economic size (GDP), government factor, political size, financial depth, etc. of countries could have accounted for the difference in adjustment speed. Our MG estimates were found robust to a GMM specification. The study concludes that there is a dynamics interaction between exchange rate regime, import prices and foreign exchange reserves holding. We so recommended that African countries should strategically implement policies to reduce their inflation rates, dependence on import, effectively manage exchange rate regime so that they can achieve higher volume of external reserve holdings that will lead to a reduction in their import prices.
Effect of Different Plant Growth Regulators on Fruit Yield and Quality Parameters of Cucumber (Cucumis sativus L.) cv. Punjab Naveen
Authors: Bajaj Smile , Kumar Deepak , Singh Navdeep , Gangwar Vishal , Wamiq Mohd , Pal Om , Dishri Madhusmita
Published: September 2022

An experimental trial was carried out during the season from March 2018 – June 2018 at the Horticulture farm of Lovely Professional University, Phagwara (Punjab). utilising a randomised block design, the experimental trial consists three replications. The current study included eleven treatments, including a control with different PGR dosages of Maleic hydrazide (200, 250, and 300 ppm, MH), Naphthalene acetic acid (50, 100, and 150ppm, NAA), and Gibberellic acid (50,100 and 150 ppm, GA3). Based on the results of the experiment, it was concluded that the treatment T8 (100 ppm GA3) significantly affected the cucumber's fruit yield parameters and treatment T7 (50ppm GA3) showed the better results in quality attributes Viz., TSS and fruit texture.
Effect of Different Sowing Dates and Varieties on Mustard Growth and Yield in Prayagraj Conditions
Authors: Samota Sunil Kumar , Sharma Roshan , Paliwal H. B.
Published: September 2022

A field experiment was conducted during the winter seasons of 2021-22 at the Research farm of the college of forestry Sam Higginbottom University of Agriculture Technology and Science Prayagraj (U. P) to investigate the effect of different sowing dates and varieties on Mustard growth and yield in Prayagraj conditions Keeping in this view experiment was conducted in Factorial RBD with three replications having two factors.  First factor comprised of three dates of sowing 15Oct. 30Oct. and 15Nov. whereas the second factor consists of three Indian mustard varieties viz; Maharaja Mustard, Md Rani Supergold, Kala Sona, Crop sown on 15th November was recorded statistically significant higher seed yield, stover yield, test weight, harvest index and at maturity best consumption of heat units like gdd, htu and ptu as compared to 30th October and 15th October sowing. In the case of plant growth parameters of mustard, maximum was recorded under 15th November as compared to 30th October and 15th October and in case of varieties maximum plant growth like plant height, no of leaves no of branches, no of silique, and optimum use of heat units was recorded with md rani super gold as compared to kala sona and maharaja. The treatment with the date of sowing 15th November and md rani super gold variety proved the most remunerative and economically feasible for the cultivation of Indian mustard under the agro-climatic conditions of Prayagraj U.P.
An Observational Cross-sectional Single Arm Trial and Perspective Study of Siddha Diagnostic Tool Neerkuri and Neikuri (Uroscopy) in COVID-19 Patients
Authors: Jeyavenkatesh J. , Ramani S. Roja , Saravanapandian P. , Bai P. Mujeetha , Priya R. Shanmuga
Published: September 2022

Aim: Siddha diagnostic method neerkuri includes the visual observation of urine directly or by adding one drop of gingelly oil on the urine surface. The study is an effort to understand the non-invasive affordable Siddha method of identifying pathological disorders, which may be used for both diagnostic and prognostic purposes in COVID cases. The present aim is to observe the changes in the urine before and after the Siddha fixed treatment regimen and validate the effectiveness of neerkuri-neikuri urine test mentioned in Siddha texts.

Presentation of Case: This study was conducted among ten patients with SARS-CoV2 infection admitted in Kokila Siddha Hospital and Research Centre, COVID-ward. They underwent modern tests as well as Siddha diagnostic test neerkuri-neikuri and the results interpreted. For adequate assessment, the entire procedure was captured in the form of video clips.

Discussion: The foundation of neerkuri-neikuri is one of the Envagaithervu (Eight-fold assessment) of Siddha diagnosis based on three humor theory, fundamental physiology and it alter with specific infection. The neerkuri-neikuri tests are rational criteria that are comprehensive to understand one's health and illness status based on Siddha physiopathology.

Conclusion: After the administration of the Siddha intervention, the neerkuri-neikuri test results also showed good improvement along the clinical symptoms and modern laboratory parameters of patient tests. The prognostic clinical findings and modern test results were also simultaneously reflected in the neerkuri-neikuri tests. After the completion of Siddha treatment, the neikuri patterns also reached single kabha humor in muthu (pearl), vatha humor in aravu(snake) and sangu (conch-shell) patterns from three humor state, which indicated a good prognosis.