bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancing stroke patient care: a network meta-analysis of dysphagia screening efficacy and personalization
Authors: Jiang Youli , Chi Yue , Pan Rongjia , Zhang Dongqi , Huang Suzhen , Ju Hao , Li Yanfeng
Published: August 2024

Introduction

The increasing incidence of stroke globally has led to dysphagia becoming one of the most common complications in stroke patients, with significant impacts on patient outcomes. Accurate early screening for dysphagia is crucial to avoid complications and improve patient quality of life.

Methods

Included studies involved stroke-diagnosed patients assessed for dysphagia using bedside screening tools. Data was sourced from Embase, PubMed, Web of Science, Scopus, and CINAHL, including publications up to 10 December 2023. The study employed both fixed-effect and random-effects models to analyze sensitivity, specificity, positive predictive value (PPV), and Negative Predictive Value (NPV), each with 95% confidence intervals. The random-effects model was particularly utilized due to observed heterogeneity in study data.

Results

From 6,979 records, 21 studies met the inclusion criteria, involving 3,314 participants from 10 countries. The analysis included six assessment tools: GUSS, MASA, V-VST, BSST, WST, and DNTA, compared against gold-standard methods VFSS and FEES. GUSS, MASA, and V-VST showed the highest reliability, with sensitivity and specificity rates of 92% and 85% for GUSS, 89% and 83% for MASA, respectively. Heterogeneity among studies was minimal, and publication bias was low, enhancing the credibility of the findings.

Conclusion

Our network meta-analysis underscores the effectiveness of GUSS, MASA, and V-VST in dysphagia screening for stroke patients, with high sensitivity and specificity making them suitable for diverse clinical settings. BSST and WST, with lower diagnostic accuracy, require more selective use. Future research should integrate patient-specific outcomes and standardize methodologies to enhance dysphagia screening tools, ultimately improving patient care and reducing complications.

Systematic review registration

https://www.crd.york.ac.uk/PROSPERO/#recordDetails.
Comparison and combined use of NEWS2 and GCS scores in predicting mortality in stroke and traumatic brain injury: a multicenter retrospective study
Authors: Hu Wei , Shang Ke , Chen Liqin , Wang Xin , Li Xia
Published: August 2024

Objective

This study aims to assess the effectiveness of the National Early Warning Score 2 (NEWS2) versus Glasgow Coma Scale (GCS) in predicting hospital mortality among patients with stroke and traumatic brain injury (TBI).

Location

This multicenter study was conducted at two anonymized tertiary care hospitals in distinct climatic regions of China, with a combined annual emergency admission exceeding 10,000 patients.

Patients

The study included 2,276 adult emergency admissions diagnosed with stroke (n = 1,088) or TBI (n = 1,188) from January 2021 to December 2023, excluding those with chronic pulmonary disease, severe cardiac conditions, or a history of brain surgery.

Measuring and main outcomes

The receiver operating characteristic (ROC) curve and the area under the curve (AUC) were utilized to analyze the predictive accuracy of NEWS2 and GCS for hospital mortality at 24, 48, and 72 h post-admission and at discharge.

Results

Out of 2,276 patients (mean age 61.4, 65.6% male), 1855 survived while 421 succumbed. NEWS2 demonstrated superior predictive accuracy (AUC = 0.962) over GCS (AUC = 0.854) for overall hospital mortality. Specifically, NEWS2 outperformed GCS in predicting mortality at 24 h (0.917 vs. 0.843), 48 h (0.893 vs. 0.803), and 72 h (0.902 vs. 0.763). Notably, despite a higher AUC for NEWS2 at predicting 24-h hospital mortality, the sensitivity and specificity of GCS were considerably lower (12 and 31%, respectively) compared to NEWS2 (sensitivity of 95% and specificity of 81%). Subgroup analysis showed NEWS2 outperforming GCS in predicting in-hospital mortality for TBI and stroke patients. For TBI patients (n = 260), NEWS2 had an AUC of 0.960 (95% CI: 0.948–0.973) vs. GCS’s AUC of 0.811 (95% CI: 0.781–0.840). For stroke patients (n = 161), NEWS2 had an AUC of 0.930 (95% CI: 0.908–0.952) vs. GCS’s AUC of 0.858 (95% CI, 0.823–0.892). NEWS2 showed greater sensitivity in both groups, highlighting its effectiveness in identifying high-risk neurological patients.

Conclusion

NEWS2 scores are more precise and effective in predicting hospital mortality in stroke and TBI patients compared to GCS scores, although slightly less so within the first 24 h. Combining NEWS2 with GCS and clinical findings within the initial 24 h is recommended for a comprehensive prognosis evaluation.
Critical variables regulating age-related anabolic responses to protein nutrition in skeletal muscle
Authors: Deane Colleen S. , Cox Jake , Atherton Philip J.
Published: August 2024

Protein nutrition is critical for the maintenance of skeletal muscle mass across the lifecourse and for the growth of muscle in response to resistance exercise – both acting via the stimulation of protein synthesis. The transient anabolic response to protein feeding may vary in magnitude and duration, depending on, e.g., timing, dose, amino acid composition and delivery mode, which are in turn influenced by physical activity and age. This review aims to: (i) summarise the fundamental metabolic responses of muscle to protein feeding, (ii) discuss key variables regulating muscle anabolic responses to protein feeding, and (iii) explore how these variables can be optimised for muscle anabolism in response to physical activity and ageing.
Associations between dietary antioxidant vitamins and risk of glioma: an updated systematic review and meta-analysis of observational studies
Authors: Ni Ya-Jun , Huang Yi-Qian , Yu Lin , Zhang Xiao-Yan , Zhu Qin , Shu Long , Zhang Lun
Published: August 2024

Background

Epidemiological studies investigating the potential associations between antioxidant vitamins intake and risk of glioma have yielded inconsistent results. To address this, we carried out a systematic review and updated meta-analysis to explore the relationship between dietary antioxidant vitamins intake and risk of glioma.

Methods

We comprehensively searched electronic databases including PubMed, Web of Science, Embase, Scopus, China National Knowledge Infrastructure (CNKI) and Wan fang Data from their inception to March 2024. We employed fixed-effects or random-effects models to estimate the pooled relative risks (RRs) and 95% confidence intervals (CIs) for the associations between dietary antioxidant vitamins intake and risk of glioma. Publication bias was assessed through the visual inspection of the funnel plots and quantified by the Begg's and Egger's tests. Heterogeneity across studies was assessed using the Cochran's Q test and I-square (I2). Additionally, subgroup and sensitivity analyses were performed to explore potential sources of heterogeneity and evaluate the robustness of the results.

Results

Overall, a total of 15 articles involving 3,608 glioma cases and 771,930 participants were included in the final analysis. The pooled analyses revealed that the highest intake of vitamin C significantly reduced the risk of glioma (RR = 0.78; 95%CI: 0.63–0.96; P = 0.022), compared to the lowest intake. However, no significant associations were observed between vitamin A and vitamin E intake and the risk of glioma (P>0.05). Subgroup analyses revealed the inverse association between vitamin C intake and risk of glioma in the population-based case-control studies (RR = 0.82; 95%CI: 0.68–1.00, P = 0.049) and study quality <7(RR = 0.52, 95%CI: 0.29–0.92, P = 0.025).

Conclusion

Our findings show that higher intake of vitamin C is strongly associated with a reduced risk of glioma, although a dose-response relationship was not evident. Future large-scale prospective studies are warranted to confirm these findings.
Predictive model for prolonged hospital stay risk after gastric cancer surgery
Authors: Zhang Xiaochun , Wei Xiao , Lin Siying , Sun Wenhao , Wang Gang , Cheng Wei , Shao Mingyue , Deng Zhengming , Jiang Zhiwei , Gong Guanwen
Published: August 2024

Background

Prolonged postoperative hospital stay following gastric cancer (GC) surgery is an important risk factor affecting patients’ mood and increasing complications. We aimed to develop a nomogram to predict risk factors associated with prolonged postoperative length of stay (PLOS) in patients undergoing gastric cancer resection.

Methods

Data were collected from 404 patients. The least absolute shrinkage and selection operator (LASSO) was used for variable screening, and a nomogram was designed. The nomogram performance was evaluated by the area under the receiver operating characteristic curve (AUC). The consistency between the predicted and actual values was evaluated via a calibration map, and the clinical application value was evaluated via decision curve analysis (DCA) and clinical impact curve analysis (CICA).

Results

A total of 404 patients were included in this study. Among these patients, 287 were assigned to the training cohort, and 117 were assigned to the validation cohort. According to the PLOS quartile distance, 103 patients were defined as having prolonged PLOS. LASSO regression and logistic multivariate analysis revealed that 4 clinical characteristics, the neutrophil–lymphocyte ratio (NLR) on postoperative day one, the NLR on postoperative day three, the preoperative prognostic nutrition index and the first time anal exhaust was performed, were associated with the PLOS and were included in the construction of the nomogram. The AUC of the nomogram prediction model was 0.990 for the training set and 0.983 for the validation set. The calibration curve indicated good correlation between the predicted results and the actual results. The Hosmer-Lemeshow test revealed that the P values for the training and validation sets were 0.444 and 0.607, respectively, indicating that the model had good goodness of fit. The decision curve analysis and clinical impact curve of this model showed good clinical practicability for both cohorts.

Conclusion

We explored the risk factors for prolonged PLOS in GC patients via the enhanced recovery after surgery (ERAS) program and developed a predictive model. The designed nomogram is expected to be an accurate and personalized tool for predicting the risk and prognosis of PLOS in GC patients via ERAS measures.
Daidzein ameliorates peripheral neuropathy in Sprague Dawley rats
Authors: Laddha Ankit P. , Kulkarni Yogesh A.
Published: August 2024

Neuropathy is the most common disorder comprising peripheral nerve damage in diabetic patients. Prolonged hyperglycaemia and oxidative stress cause metabolic imbalance and are the key reasons for the development of diabetic neuropathy. Daidzein, a soy isoflavone possesses potent anti-hyperglycaemic and antioxidant activity. The present study aims to check the protective effect of Daidzein in diabetic neuropathy in rats. The experimental animal model involved induction of diabetes in rats by intraperitoneal injection of streptozotocin (55 mg/kg). Following confirmation of diabetes, the diabetic rats were subjected to oral treatment with varying doses of Daidzein (25, 50, and 100 mg/kg) and pregabalin (30 mg/kg) for a duration of 4 weeks, initiated 6 weeks after diabetes induction. Results indicated that Daidzein treatment led to a significant reduction in plasma glucose levels and an improvement in body weight among diabetic animals. Moreover, Daidzein demonstrated a positive impact on sensory functions, as evidenced by the effect on tail withdrawal and response latency. Mechanical hyperalgesia and allodynia, common symptoms of diabetic neuropathy, were also significantly reduced with both Daidzein and pregabalin treatment. Notably, nerve conduction velocities exhibited improvement following the administration of Daidzein and pregabalin. Further investigation into the molecular mechanisms revealed that Daidzein treatment resulted in a notable enhancement of antioxidant enzyme levels and a reduction in the overexpression of NOX-4 in the sciatic nerve. This suggests that Daidzein’s therapeutic effect is associated with the inhibition of oxidative stress via NOX-4. In summary, the findings of study suggests that, Daidzein treatment significantly attenuated diabetic neuropathy by inhibiting oxidative stress via NOX-4 inhibition.
Effect of circadian clock disruption on type 2 diabetes
Authors: Tran Hong Thuan , Kondo Takeru , Ashry Amal , Fu Yunyu , Okawa Hiroko , Sawangmake Chenphop , Egusa Hiroshi
Published: August 2024

Introduction

Type 2 diabetes (T2D) is the predominant form of diabetes mellitus and is among the leading causes of death with an increasing prevalence worldwide. However, the pathological mechanism underlying T2D remains complex and unclear. An increasing number of studies have suggested an association between circadian clock disruption and high T2D prevalence.

Method

This review explores the physiological and genetic evidence underlying T2D symptoms associated with circadian clock disturbances, including insulin secretion and glucose metabolism.

Results and Discussion

Notably, circadian clock disruption reduces insulin secretion and insulin sensitivity and negatively affects glucose homeostasis. The circadian clock regulates the hypothalamic–pituitary–adrenal axis, an important factor that regulates glucose metabolism and influences T2D progression. Therefore, circadian clock regulation is an attractive, novel therapeutic approach for T2D, and various circadian clock stabilizers play therapeutic roles in T2D. Lastly, this review suggests novel therapeutic and preventive approaches using circadian clock regulators for T2D.
Biological features and quality comprehensive analysis of twelve germplasm resources of the genus Allium from Tibet
Authors: Wang Huaifeng , Yang Haixing , Yu Xuena , Xie Yongdong , Bai Yu , Dai Qiya , Liang Le , Tang Wen , Yong Mao , Wang Luzhou , Huang Zhi , Sun Bo , Li Huanxiu , Tang Yi
Published: August 2024

Introduction

Allium is important vegetables and seasonings in China, Tibet is rich in unique resources of the genus Allium, but lacks development and utilization.

Methods

We compared the biological features and comprehensively evaluating the quality of twelve germplasm resources of the genus Allium collected from Tibet.

Results

The results revealed that nine germplasm resources were bolting and bloom normally except for SC015, SC019, and SC048, all twelve germplasm resources were able to vegetative growth. The individual differences in moisture, soluble sugar, and protein content among the twelve germplasm resources were relatively small, with pyruvic acid content ranging from 0.11 to 1.12 mg/g and a large variation coefficient. A total of 8 categories and 97 volatile compounds were detected in twelve germplasm resources, the majority possessed the highest proportions of aldehydes and organosulfur compounds, but there were certain differences between the different Allium species. Additionally, 11 to 16 types of free amino acids were present in all germplasm resources, proline exhibited the highest content. The total content of essential and non-essential amino acids in SC009 was the highest. Carbon (C) accounted for the largest proportion of all elements, and the contents of other mineral elements varied greatly among the different plants.

Conclusion

In conclusion, combined with biological performance and comprehensive evaluation of quality, SC009 is the excellent germplasm resource suitable for growth and capable of reproduction with good quality. These results improved the exploitation and utilization of the genus Allium in Tibet, as well as provided germplasm resources for high-quality breeding of the genus Allium.
Voice from both sides: a molecular dialogue between transcriptional activators and repressors in seed-to-seedling transition and crop adaptation
Authors: Go Dongeun , Lu Bailan , Alizadeh Milad , Gazzarrini Sonia , Song Liang
Published: August 2024

High-quality seeds provide valuable nutrients to human society and ensure successful seedling establishment. During maturation, seeds accumulate storage compounds that are required to sustain seedling growth during germination. This review focuses on the epigenetic repression of the embryonic and seed maturation programs in seedlings. We begin with an extensive overview of mutants affecting these processes, illustrating the roles of core proteins and accessory components in the epigenetic machinery by comparing mutants at both phenotypic and molecular levels. We highlight how omics assays help uncover target-specific functional specialization and coordination among various epigenetic mechanisms. Furthermore, we provide an in-depth discussion on the Seed dormancy 4 (Sdr4) transcriptional corepressor family, comparing and contrasting their regulation of seed germination in the dicotyledonous species Arabidopsis and two monocotyledonous crops, rice and wheat. Finally, we compare the similarities in the activation and repression of the embryonic and seed maturation programs through a shared set of cis-regulatory elements and discuss the challenges in applying knowledge largely gained in model species to crops.
Identification of differential gene expression related to reproduction in the sporophytes of Saccharina japonica
Authors: Uji Toshiki , Kandori Takuya , Mizuta Hiroyuki
Published: August 2024

Saccharina japonica, a significant brown macroalga in the Pacific Ocean, serves as a food source and industrial material. In aquaculture, collecting mature sporophytes for seedling production is essential but challenging due to environmental changes. In this study, transcriptomic analysis of vegetative and sorus tissues was done to identify differentially expressed genes (DEGs) and enhance our understanding of sorus formation regulation in S. japonica. KEGG pathway and Gene Otology (GO) analysis revealed that upregulated DEGs were involved in folate biosynthesis, riboflavin metabolism, and amino acid biosynthesis. In addition, the upregulation of genes associated with cell wall remodeling, such as mannuronan C-5-epimerases, vanadium-dependent haloperoxidases, and NADPH oxidase, was observed in sorus parts. Meanwhile, downregulated DEGs in sorus portions included genes related to chloroplast function. These findings will help us understand the regulatory mechanisms behind sorus formation in S. japonica and extracellular matrix remodeling in brown algae.
A lightweight dual-attention network for tomato leaf disease identification
Authors: Zhang Enxu , Zhang Ning , Li Fei , Lv Cheng
Published: August 2024

Tomato disease image recognition plays a crucial role in agricultural production. Today, while machine vision methods based on deep learning have achieved some success in disease recognition, they still face several challenges. These include issues such as imbalanced datasets, unclear disease features, small inter-class differences, and large intra-class variations. To address these challenges, this paper proposes a method for classifying and recognizing tomato leaf diseases based on machine vision. First, to enhance the disease feature details in images, a piecewise linear transformation method is used for image enhancement, and oversampling is employed to expand the dataset, compensating for the imbalanced dataset. Next, this paper introduces a convolutional block with a dual attention mechanism called DAC Block, which is used to construct a lightweight model named LDAMNet. The DAC Block innovatively uses Hybrid Channel Attention (HCA) and Coordinate Attention (CSA) to process channel information and spatial information of input images respectively, enhancing the model’s feature extraction capabilities. Additionally, this paper proposes a Robust Cross-Entropy (RCE) loss function that is robust to noisy labels, aimed at reducing the impact of noisy labels on the LDAMNet model during training. Experimental results show that this method achieves an average recognition accuracy of 98.71% on the tomato disease dataset, effectively retaining disease information in images and capturing disease areas. Furthermore, the method also demonstrates strong recognition capabilities on rice crop disease datasets, indicating good generalization performance and the ability to function effectively in disease recognition across different crops. The research findings of this paper provide new ideas and methods for the field of crop disease recognition. However, future research needs to further optimize the model’s structure and computational efficiency, and validate its application effects in more practical scenarios.
Botrytis cinerea causes different plant responses in grape (Vitis vinifera) berries during noble and grey rot: diverse metabolism versus simple defence
Authors: Váczy Kálmán Z. , Otto Margot , Gomba-Tóth Adrienn , Geiger Adrienn , Golen Richárd , Hegyi-Kaló Júlia , Cels Thomas , Geml József , Zsófi Zsolt , Hegyi Ádám István
Published: August 2024

The complexity of the interaction between the necrotrophic pathogen Botrytis cinerea and grape berries (Vitis vinifera spp.) can result in the formation of either the preferred noble rot (NR) or the loss-making grey rot (GR), depending on the prevailing climatic conditions. In this study, we focus on the functional gene set of V. vinifera by performing multidimensional scaling followed by differential expression and enrichment analyses. The aim of this study is to identify the differences in gene expression between grape berries in the phases of grey rot, noble rot, and developing rot (DR, in its early stages) phases. The grapevine transcriptome at the NR phase was found to exhibit significant differences from that at the DR and GR stages, which displayed strong similarities. Similarly, several plant defence-related pathways, including plant-pathogen interactions as hypersensitive plant responses were found to be enriched. The results of the analyses identified a potential plant stress response pathway (SGT1 activated hypersensitive response) that was found to be upregulated in the GR berry but downregulated in the NR berry. The study revealed a decrease in defence-related in V. vinifera genes during the NR stages, with a high degree of variability in functions, particularly in enriched pathways. This indicates that the plant is not actively defending itself against Botrytis cinerea, which is otherwise present on its surface with high biomass. This discrepancy underscores the notion that during the NR phase, the grapevine and the pathogenic fungi interact in a state of equilibrium. Conversely the initial stages of botrytis infection manifest as a virulent fungus-plant interaction, irrespective of whether the outcome is grey or noble rot.
Dynamic patterns of gene expressional and regulatory variations in cotton heterosis
Authors: Huang Chujun , Cheng Yu , Hu Yan , Fang Lei , Si Zhanfeng , Chen Jinwen , Cao Yiwen , Guan Xueying , Zhang Tianzhen
Published: August 2024

Purpose

Although the application of heterosis has significantly increased crop yield over the past century, the mechanisms underlying this phenomenon still remain obscure. Here, we applied transcriptome sequencing to unravel the impacts of parental expression differences and transcriptomic reprogramming in cotton heterosis.

Methods

A high-quality transcriptomic atlas covering 15 developmental stages and tissues was constructed for XZM2, an elite hybrid of upland cotton (Gossypium hirsutum L.), and its parental lines, CRI12 and J8891. This atlas allowed us to identify gene expression differences between the parents and to characterize the transcriptomic reprogramming that occurs in the hybrid.

Results

Our analysis revealed abundant gene expression differences between the parents, with pronounced tissue specificity; a total of 1,112 genes exhibited single-parent expression in at least one tissue. It also illuminated transcriptomic reprogramming in the hybrid XZM2, which included both additive and non-additive expression patterns. Coexpression networks between parents and hybrid constructed via weighted gene coexpression network analysis identified modules closely associated with fiber development. In particular, key regulatory hub genes involved in fiber development showed high-parent dominant or over dominant patterns in the hybrid, potentially driving the emergence of heterosis. Finally, high-depth resequencing data was generated and allele-specific expression patterns examined in the hybrid, enabling the dissection of cis- and trans-regulation contributions to the observed expression differences.

Conclusion

Parental transcriptional differences and transcriptomic reprogramming in the hybrid, especially the non-additive upregulation of key genes, play an important role in shaping heterosis. Collectively, these findings provide new insights into the molecular basis of heterosis in cotton.
Analysis of the causes, psychological mechanisms, and coping strategies of short video addiction in China
Authors: Liao Mingyue
Published: August 2024

Short video addiction refers to the uncontrollable desire of users to watch short videos, leading to significant behavioral loss of control or attention disorders, which in turn result in difficulties in social interaction, learning, and work adaptation. With the “invasion” of short videos into people’s daily lives and their spread among underage groups, the issue of short video addiction has attracted widespread social attention. Firstly, based on the causes of short video addiction, this study analyzes it from four levels: algorithm design, content services, platform control, and user experience. Secondly, combining relevant scientific theories, the psychological mechanisms of short video addiction are explained from four levels: cognition, emotion, motivation, and social factors. Finally, in terms of coping strategies, on the theoretical level, further research on the occurrence mechanism of short video addiction should be deepened, and attention should be paid to the influence of recommendation algorithms on short video addiction. On the practical level, the obligations and responsibilities of relevant stakeholders such as short video producers, platforms, and regulators in preventing short video addiction should be clarified, aiming to promote prevention and management of short video addiction.
Examining the link between coach-athlete relationship and athlete burnout among college soccer players: the mediating role of training satisfaction
Authors: Jiahao Liu , Jing Li
Published: August 2024

Purpose

Athlete burnout is an adverse factor that usually decreases athletes' sports performance and reduces their passion for athletic career development. The present study examined the association of coach-athlete relationship, training satisfaction, and athlete burnout, and then explored the training satisfaction as a mediating role of the effect of coach-athlete relationship on athlete burnout among college soccer players.

Methods

Soccer players from seven Chinese higher education institutions were recruited for the study. The participants were selected using stratified random sampling and included 218 participants. The Coach-Athlete Relationship Scale, Training Satisfaction Scale, and Athlete Burnout Questionnaire were used to collect data from the participants. Pearson's product-moment correlation analysis, linear regression analysis, and bootstrap method were conducted to analyze the collected data set.

Results

The results showed that (1) there was a significant correlation between coach-athlete relationship, training satisfaction, and athlete burnout. (2) coach-athlete relationship and training satisfaction significantly negatively predicted athlete burnout (β = −0.39, p < 0.001; β = - 0.29, p < 0.001). (3) training satisfaction had a significantly mediating effect on the relationship between coach-athlete relationship and athlete burnout (β = −0.15, p < 0.001, ES = 0.28).

Conclusion

Coach-athlete relationship can not only directly negative impact athlete burnout but can also negatively influence athlete burnout through the mediating effect of training satisfaction. Therefore, we suggest the following to alleviate athlete burnout: on one hand, coaches can provide more communication opportunities for athletes to improve the coach-athlete relationship. On the other hand, teams can enhance training satisfaction by building team culture.
Stochastic heuristics for decisions under risk and uncertainty
Authors: Spiliopoulos Leonidas , Hertwig Ralph
Published: August 2024

Models of heuristics are often predicated on the desideratum that they should possess no free parameters. As a result, heuristic implementations are usually deterministic and do not allow for any choice errors, as the latter would require a parameter to regulate the magnitude of errors. We discuss the implications of this in light of research that highlights the evidence supporting stochastic choice and its dependence on preferential strength. We argue that, in principle, the existing models of deterministic heuristics should, and can, be quite easily modified to stochastic counterparts through the addition of an error mechanism. This requires a single free parameter in the error mechanism, whilst otherwise retaining the parameter-free cognitive processes in the deterministic component of existing heuristics. We present various types of error mechanisms applicable to heuristics and discuss their comparative virtues and drawbacks, paying particular attention to their impact on model comparisons between heuristics and parameter-rich models.
From diagnosis to dialogue – reconsidering the DSM as a conversation piece in mental health care: a hypothesis and theory
Authors: Veldmeijer Lars , Terlouw Gijs , van Os Jim , te Meerman Sanne , van ‘t Veer Job , Boonstra Nynke
Published: August 2024

The Diagnostic and Statistical Manual of Mental Disorders, abbreviated as the DSM, is one of mental health care’s most commonly used classification systems. While the DSM has been successful in establishing a shared language for researching and communicating about mental distress, it has its limitations as an empirical compass. In the transformation of mental health care towards a system that is centered around shared decision-making, person-centered care, and personal recovery, the DSM is problematic as it promotes the disengagement of people with mental distress and is primarily a tool developed for professionals to communicate about patients instead of with patients. However, the mental health care system is set up in such a way that we cannot do without the DSM for the time being. In this paper, we aimed to describe the position and role the DSM may have in a mental health care system that is evolving from a medical paradigm to a more self-contained profession in which there is increased accommodation of other perspectives. First, our analysis highlights the DSM’s potential as a boundary object in clinical practice, that could support a shared language between patients and professionals. Using the DSM as a conversation piece, a language accommodating diverse perspectives can be co-created. Second, we delve into why people with lived experience should be involved in co-designing spectra of distress. We propose an iterative design and test approach for designing DSM spectra of distress in co-creation with people with lived experience to prevent the development of ‘average solutions’ for ‘ordinary people’. We conclude that transforming mental health care by reconsidering the DSM as a boundary object and conversation piece between activity systems could be a step in the right direction, shifting the power balance towards shared ownership in a participation era that fosters dialogue instead of diagnosis.
Prison healthcare service use and associated factors: a cross sectional study in Northwestern Ethiopia
Authors: Yesuf Yassin Mohammed , Birhan Amlaku Alemu , Birara Addisu Gedlu , Adimas Bewket Dereje , Bezabh Abebe Bahiru , Agmase Nega Gedefaw
Published: August 2024

Introduction

Studies on inmates’ Health Care Service (HCS) utilization are scarce globally, infrequent in Ethiopia while findings about the factors associated with HCS utilization are inconsistent. The present study, therefore, examined inmates’ HCS utilization and associated socio-demographic and imprisonment related factors in Northwestern Ethiopia.

Methods

The study employed institution-based cross sectional research design and data was collected using questionnaire from 422 inmates in three prisons. The questionnaire collected data about prisoners’ demographic characters, imprisonment related information and HCS utilization. Descriptive statistical techniques as well as bi-variate and multiple logistic regressions were used to analyse the data.

Results and discussions

The study found that 72.5%, 66.1% and 13.3% of the inmates, respectively, used medical services, guidance and counseling services, and psychiatric services. Inmates with primary education, with secondary education, and who know the availability of the services were more likely to use medical services. Inmates with accused status were less likely to use medical services than inmates with convict status. Divorced marital status and knowledge of the service availability were associated with high guidance and counseling service use. An increase in the length of stay in the prison was associated with a decrease in psychiatry service use while knowledge of service availability was associated with higher odds of psychiatry service use. There are high medical care service utilization while low mental health care service utilization among inmates in Northwestern Ethiopia. Results of the study implied that there is a critical need for immediate health care service promotion and education measures. Besides, there are also needs for large scale, longitudinal and potentially cross-cultural studies to better understand additional factors that influence inmates’ HCS utilization.
Severity of inattention symptoms, experiences of being bullied, and school anxiety as mediators in the association between excessive short-form video viewing and school refusal behaviors in adolescents
Authors: Du Yuru , Wang Jianqiang , Wang Ziyan , Liu Jiuying , Li Shaoxiong , Lv Jing , Peng Yuhan , Chang Shining , Li Miaomiao , Liu Huan , Liu Xuan , Yu Xuezhu , Li Youdong
Published: August 2024

Background

Recent years have seen an increase in school refusal behavior among adolescents, potentially due to factors like excessive short-form video viewing, bullying, and school anxiety. Limited research has investigated how these factors contribute to school refusal behavior. This study used random forest regression, path analysis, and network analysis to identify key variables and pathways leading to school refusal behavior.

Methods

In this cross-sectional questionnaire-based study, 2,056 (996 male, 1,060 female, mean age: 14.79 ± 1.24 years) middle and senior high school students were asked to complete the School Refusal Behavior Assessment questionnaire to assess school refusal behavior features, the Excessive Short-Form Video Viewing Scale as well as self-reported viewing times during leisure days to assess excessive short-form video viewing, the SNAP-IV Rating Scale to assess the severity of inattention symptoms, and the self-administered questionnaires to assess experiences of being bullied and school anxiety.

Results

The prevalence of school refusal behavior in the surveyed adolescents was found to be 31.9% [95% confidence interval (CI): 29.8–33.9%]. In terms of significance, the severity of inattention symptoms exhibited the greatest predictive power, while excessive short-form video viewing accounted for the most variance. Path analysis revealed that excessive short-form video viewing not only directly affects school refusal behavior features but also does so indirectly through severity of inattention symptoms and school anxiety. Key bridge factors in this pathway include intense fear and anxiety associated with school attendance, manifesting as somatic symptoms and avoidance behaviors.

Conclusion

The findings indicate that not only does excessive short-form video viewing directly influence school refusal behavior features in adolescents, but it also indirectly impacts these features through mechanisms involving severity of inattention symptoms and school anxiety. The bridge factors highlight potential targets for interventions among the SRB features and predictors.
Enhancing the design of voting advice applications with BERT language model
Authors: Buryakov Daniil , Kovacs Mate , Serdült Uwe , Kryssanov Victor
Published: August 2024

The relevance and importance of voting advice applications (VAAs) are demonstrated by their popularity among potential voters. On average, around 30% of voters take into account the recommendations of these applications during elections. The comparison between potential voters' and parties' positions is made on the basis of VAA policy statements on which users are asked to express opinions. VAA designers devote substantial time and effort to analyzing domestic and international politics to formulate policy statements and select those to be included in the application. This procedure involves manually reading and evaluating a large volume of publicly available data, primarily party manifestos. A problematic part of the work is the limited time frame. This study proposes a system to assist VAA designers in formulating, revising, and selecting policy statements. Using pre-trained language models and machine learning methods to process politics-related textual data, the system produces a set of suggestions corresponding to relevant VAA statements. Experiments were conducted using party manifestos and YouTube comments from Japan, combined with VAA policy statements from six Japanese and two European VAAs. The technical approaches used in the system are based on the BERT language model, which is known for its capability to capture the context of words in the documents. Although the output of the system does not completely eliminate the need for manual human assessment, it provides valuable suggestions for updating VAA policy statements on an objective, i.e., bias-free, basis.
Histopathologic predictors of recurrence and survival in early T stage oral tongue squamous cell carcinoma
Authors: Damazo Benjamin J. , Punjabi Nihal A. , Liu Yuan F. , Inman Jared C.
Published: August 2024

Objectives

Recurrence and survival in early T-stage oral tongue squamous cell carcinoma (OTSCC) may be impacted by histopathologic risk factors. This study aims to examine which of these factors predict long-term outcomes of T1 and T2 OTSCC.

Methods

A retrospective review of T1 and T2 OTSCC patients treated with surgery at a single tertiary care center was conducted. Multivariate regression and Kaplan-Meier survival plots were used to identify predictors of recurrence and compare disease-free survival respectively.

Results

100 consecutive patients were studied. Of these, 51 were staged pT1, 49 pT2, 69 pN0, 10 pN1, and 21 pN2. Multivariate regression analysis revealed that >4 nodes was the strongest predictor of overall recurrence [odds ratio 1.68 (1.23–2.28), p = 0.001], while >4 nodes [odds ratio 1.14 (1.09–1.85), p = 0.008] and pT2 [odds ratio 1.15 (1.01–1.30), p = 0.033] were predictors of local recurrence (R2 = 0.112). Five-year disease-free survival was not significantly impacted by any risk factors except for the number of positive nodes—86% for ≤4 nodes vs. 20% for >4 nodes (p < 0.001)—and pathologic T-stage—90% for pT1 vs. 75% for pT2 (p = 0.035) regardless of adjuvant radiation and/or chemotherapy use.

Conclusions

Patients who underwent adjuvant radiation and/or chemotherapy had similar survival to those who did not despite having worse overall tumor prognostic factors. Adding adjuvant therapy may equalize some high-risk histopathologic factors. In the highest risk patients—specifically those with pathologic >4 nodes and pT2 staging—adjuvant therapy should be considered.
Drinking water quality impacts oocyte viability and embryo development
Authors: Winstanley Yasmyn E. , Gonzalez Macarena B. , Andreas Eryk , Connaughton Haley , Bergen Jean , Ween Miranda , Russell Darryl L. , Shearer Cameron J. , Robertson Sarah A. , Robker Rebecca L.
Published: August 2024

Normal reproductive function and fertility is considered a “sixth vital sign” because disruptions to this sensitive physiological system can forewarn other health issues, including exposure to environmental toxicants. We found that female mice exhibited profound loss of embryos during pre-implantation and fetal development coincident with a change to the source of their drinking water. When female mice were provided with tap water from the building in which they were housed (Water 2), instead of tap water from a neighboring building which was their previous supply (Water 1), ovulated oocytes were degenerated or had impaired meiotic maturation, and failed to form embryos. The harmful effects of Water 2 exposure were not reversible even following a recovery period; however, carbon-filtration of Water 2 removed the toxic contaminant. Water composition analysis to identify the responsible toxicant(s) found that trace elements were present at expected levels and phthalates were undetectable. Per- and Poly-fluoroalkyl Substances (PFAS), a family of persistent organic pollutants were detected at ∼4 ng/L. To investigate further, female mice were given drinking water categorized by level of PFAS contamination (0.6 ng/L, 2.8 ng/L, or 4.4 ng/L) for 9 weeks. Compared to mice consuming purified MilliQ water, mice consuming PFAS-contaminated water had decreased oocyte quality, impaired embryogenesis and reduced cell numbers in blastocysts. PFAS concentration in the drinking water was negatively correlated with oocyte viability. Importantly, the levels of PFAS detected in the tap water are within current “safe level” guidelines, and further research is needed to determine whether PFAS are responsible for the observed reproductive toxicity. However, this research demonstrating that water deemed suitable for human consumption has detrimental effects on mammalian embryo development has important implications for public health and water quality policies.
Understanding inequalities in the coverage of adolescent sexual and reproductive health services: a qualitative case study of the selected regions of Zambia
Authors: Munakampe Margarate Nzala , Ngoma-Hazemba Alice , Sampa Mutale , Jacobs Choolwe N.
Published: August 2024

Introduction

Despite substantial investment in improving healthcare among adolescents in low- and middle-income countries, barriers to access and utilization of services persist, especially to sexual and reproductive health (SRH) services. In response to adolescents' health service needs due to their vulnerability, interventions aimed at improving access and utilization of sexual and reproductive health services have been implemented in specific regions of Zambia. To highlight progress in the access and the overall delivery of services in Zambia, in the wake of a system-level funding mechanism, this paper aims to understand the accessibility, availability, acceptability and quality (AAAQ) of health services provided to young people.

Materials and methods

In a qualitative case study, 48 discussions- 32 individual interviews with stakeholders and 16 focus group discussions, consisting of 128 male and female adolescents were conducted in six districts from Eastern, Southern and Muchinga provinces of Zambia. Interviews were audio-recorded, recordings transcribed verbatim, and transcripts were analysed using deductive thematic analysis, using the AAAQ framework and Atun's framework on integration, as a guide to reporting the findings.

Results

We found that adolescents knew of and had access to common commodities and services- male condoms, health education and HIV counselling and testing. However, availability was affected by access-related barriers such as frequent stock-outs and insufficiently trained healthcare providers. In addition, accessibility was more restricted during the COVID-19 pandemic lockdown and compounded by the low acceptability of SRH service among adolescents across all contexts. This led to the use of alternatives such as herbal medicine and maintained common myths and misconceptions. The overall quality was marred by the lack of dedicated spaces for adolescent health services and the lack of information, education and communication (IEC) materials in some spaces.

Conclusion

While it was noted that some services were available for adolescents in all the study sites, numerous barriers inhibited access to these services and had an impact on the quality-of-service provision. With the added restriction to SRH service asses for young people, due to the low acceptability of adolescent SRH service use, the overall integration of adolescent SRH interventions into routine service provision was low and can be improved by targeting contextual barriers and maintaining best practices.
Integrated care systems in England: the significance of collaborative community assets in promoting and sustaining health and wellbeing
Authors: Corrigan Oonagh , Danielsen Scott , Doherty Shannon , Lane Pauline
Published: August 2024

Until recently the healthcare system in England was based on a commissioning/provider model. However, this has been replaced with an Integrated Care Systems (ICSs) approach, aimed at improving health and wellbeing and reducing inequalities through local collaborative partnerships with public sector organizations, community groups, social enterprise organizations and other local agencies. Part of this new approach is an emphasis on the role of community assets (i.e., local resources), that are considered integral to promoting positive health and wellbeing outcomes. This paper presents research from a series of three research studies on “community assets” conducted in the East of England within a newly established ICS. Based on analysis of qualitative data highlighting the lived experience of community asset members, this paper shows the positive wellbeing impact on vulnerable community members that assets provide. Further insight on the local impact and the collaborative nature of the research is provided suggesting that new asset-based approaches recognize the social determinants of health. This presents a shift away from positivistic linear approaches to population health and wellbeing to a new non-linear collaborative approach to addressing health inequalities and promoting wellbeing. The authors suggest that exploring this through a complexity theory lens could illuminate this further. Finally, the authors warn that while community assets have an important role to play in empowering citizens and providing much needed support to vulnerable and disadvantaged communities, they are not a substitute for functioning funded public sector services that are currently being undermined by ongoing local governments funding cuts. As such, while community assets can help ameliorate some of the negative effects people experience due to economic, structural and health disadvantages, only a more fair and more equal distribution of resources can address growing health inequalities.
Quasi-particle–vibration coupling approach for nuclear β-decay
Authors: Colò Gianluca , Niu Yifei
Published: August 2024

The study of β-decay is important to answer open questions in physics and astrophysics; however, theoretical predictions of the associated half-lives are still plagued by uncertainties. In this short review, we argue that a reliable model for this study is nuclear density functional theory (DFT), complemented by further specific correlations; the quasi-particle–vibration coupling (QPVC) model has been successful in predicting half-lives in a number of spherical nuclei, and its extension to deformed systems should be envisioned. Some remaining open questions are addressed.