bluuebunny/crossref_metadata_2025 huggingface dataset:
POSITIVE AND NEGATIVE ASPECTS OF LEGALIZATION OF GAMING BUSINESS IN UKRAINE
Authors: Sperkach N. A. , Kytun A. P.
Published: December 2019

The article discusses the feasibility of a ban on gambling and the main shortcomings in the legislative regulation of public relations in this area. The causes of criminalization of the activity of gambling business in Ukraine are investigated and legal and practical assessment of the consequences of such criminalization is given. Possible ways of solving the problem of the shadow economy in Ukraine by overcoming illegal gambling business by example of the leading states of Europe are analyzed. The authors highlight the main problematic aspects of the existence of the gambling business outside the law and analyze the determinants that provoke such a gambling business.
The authors analyze the main negative and positive aspects of the possible legalization of the gaming industry and its impact on civil society. Bills on legalization of gambling business in Ukraine are also analyzed.
The article also examines the positive foreign experience of some foreign countries in legalizing the gambling business. In particular, some aspects of legalization are noted based on the experience of Finland, Sweden and Germany. The authors propose to introduce the experience of these states in the legislative regulation of gambling in Ukraine, in particular with regard to the creation of registers of debtors who would not be allowed to gambling, partial legalization of gambling in non-segregated territories, high license fees for gambling and high tax rates.
Also important is the fact that the authors outline the regulatory and legal aspects of regulating gambling in Ukraine, and indicate the types of liability that are currently applied to the said offense. The authors also outline a number of legal conflicts, which are in the legal acts that regulate public relations in the field of gambling.
Also relevant to the article is the fact that the authors analyzed the psychological aspect of gambling, which has a negative impact on civil society and noted the factors (determinants) of the said negative phenomenon, which generate and stimulate the development of offenses in this area.
Reliability of the 10RM test in the supine vertical press and leg extension machines
Authors: Fernandes Jefferson Dias , Medeiros Sabrina Gabrielle Coatio , Ribeiro Alexandre Lima de Araújo , Ferreira Lorena Lima Brito , Silva Adriele Amaral , Martins Wagner Rodrigues
Published: December 2019

Abstract Introduction: Several tests can predict the maximum weight an individual can lift using submaximal weights, which has been widely used in resistance training and clinical rehabilitation, but the reliability of these tests is not well documented. Objective: To analyze the test relative and absolute reliability of 10 maximum repetitions in the supine vertical bench press and leg extension machines. Method: Twenty-three healthy, untrained, and sedentary adults participated in the study. The test and retest evaluations were performed on the supine vertical press and leg extension machines. The retest was performed seven, 14 or 21 days after the test. Results: Intra-class correlation coefficient (ICC) was classified as very high (0.99) for upper limbs and (0.98) for lower limbs. The results for minimum detectable change (MDC) for the bench press resulted in a total of 2.77 kgf of actual change between test and retest, with an MDC% of 11.46%. For the leg extension, we found 3.15 kgf with MDC% of 8.94%. In both exercises, we obtained an MDC% below 30%, therefore acceptable. Conclusion: The 10RM test with the supine vertical press and leg extension has a very high relative reliability and an MDC acceptable for young, untrained and sedentary adults.
Aplicações das tecnologias Laser Scan e aerofotogrametria por drone para museus
Authors: CINTRA JORGE PIMENTEL , GONÇALES RODRIGO
Published: December 2019

RESUMO O presente trabalho apresenta alguns conceitos e diversas aplicações da tecnologia Laser Scan 3D (LS3D) para o levantamento de monumentos, peças de museu e esculturas, visando a obtenção de modelos, maquetes virtuais, filmes, exposições virtuais e maquetes em resina. Complementa-se, em alguns casos, com os levantamentos aerofotogramétricos com drone e situa-se na área que vem sendo conhecida como realidade virtual ou realidade aumentada.
PISA design model for monopiles for offshore wind turbines: application to a stiff glacial clay till
Authors: Byrne Byron W. , Houlsby Guy T. , Burd Harvey J. , Gavin Kenneth G. , Igoe David J. P. , Jardine Richard J. , Martin Christopher M. , McAdam Ross A. , Potts David M. , Taborda David M. G. , Zdravković Lidija
Published: December 2019

Offshore wind turbines in shallow coastal waters are typically supported on monopile foundations. Although three-dimensional (3D) finite-element methods are available for the design of monopiles in this context, much of the routine design work is currently conducted using simplified one-dimensional (1D) models based on the p–y method. The p–y method was originally developed for the relatively large embedded length-to-diameter ratio (L/D) piles that are typically employed in offshore oil and gas structures. Concerns exist, however, that this analysis approach may not be appropriate for monopiles with the relatively low values of L/D that are typically adopted for offshore wind turbine structures. This paper describes a new 1D design model for monopile foundations; the model is specifically formulated for offshore wind turbine applications, although the general approach could be adopted for other applications. The model draws on the conventional p–y approach, but extends it to include additional components of soil reaction that act on the pile. The 1D model is calibrated using a set of bespoke 3D finite-element analyses of monopile performance, for pile characteristics and loading conditions that span a predefined design space. The calibrated 1D model provides results that match those obtained from the 3D finite-element calibration analysis, but at a fraction of the computational cost. Moreover, within the calibration space, the 1D model is capable of delivering high-fidelity computations of monopile performance that can be used directly for design purposes. This 1D modelling approach is demonstrated for monopiles installed in a stiff, overconsolidated glacial clay till with a typical North Sea strength and stiffness profile. Although the current form of the model has been developed for homogeneous soil and monotonic loading, it forms a basis from which extensions for soil layering and cyclic loading can be developed. The general approach can be applied to other foundation and soil–structure interaction problems, in which bespoke calibration of a simplified model can lead to more efficient design.
Kidney Function Decline among Black Patients with Sickle Cell Trait and Sickle Cell Disease: An Observational Cohort Study
Authors: Olaniran Kabir O. , Allegretti Andrew S. , Zhao Sophia H. , Achebe Maureen M. , Eneanya Nwamaka D. , Thadhani Ravi I. , Nigwekar Sagar U. , Kalim Sahir
Published: December 2019

Significance Statement

Although sickle cell trait and sickle cell disease are associated with CKD among black people in the United States, longitudinal data on GFR decline in such individuals is sparse. In a cohort of black patients having sickle cell trait and sickle cell disease was associated with a significantly faster annual eGFR decline, and eGFR declined significantly faster in patients with sickle cell disease than in those with sickle cell trait. Male sex, diabetes mellitus, and high baseline GFRs were associated with faster eGFR decline in both phenotypes. In sickle cell trait, high hemoglobin S and elevated hemoglobins F and A2 were associated with a slower eGFR decline. Physicians caring for black patients need to consider sickle cell trait and sickle cell disease status and interactions with comorbidities when evaluating CKD risk.

Background

Sickle cell trait and sickle cell disease are thought to be independent risk factors for CKD, but the trajectory and predictors of kidney function decline in patients with these phenotypes are not well understood.

Methods

Our multicenter, observational study used registry data (collected January 2005 through June 2018) and included adult black patients with sickle cell trait or disease (exposures) or normal hemoglobin phenotype (reference) status (ascertained by electrophoresis) and at least 1 year of follow-up and three eGFR values. We used linear mixed models to evaluate the difference in the mean change in eGFR per year.

Results

We identified 1251 patients with sickle cell trait, 230 with sickle cell disease, and 8729 reference patients, with a median follow-up of 8 years. After adjustment, eGFR declined significantly faster in patients with sickle cell trait or sickle cell disease compared with reference patients; it also declined significantly faster in patients with sickle cell disease than in patients with sickle cell trait. Male sex, diabetes mellitus, and baseline eGFR ≥90 ml/min per 1.73 m2 were associated with faster eGFR decline for both phenotypes. In sickle cell trait, low hemoglobin S and elevated hemoglobin A were associated with faster eGFR decline, but elevated hemoglobins F and A2 were renoprotective.

Conclusions

Sickle cell trait and disease are associated with faster eGFR decline in black patients, with faster decline in sickle cell disease. Low hemoglobin S was associated with faster eGFR decline in sickle cell trait but may be confounded by concurrent hemoglobinopathies. Prospective and mechanistic studies are needed to develop best practices to attenuate eGFR decline in such patients.
Turizm Rehberliği Bölümü Öğrencilerinde Genel Öz Yeterlilik Algısı, Mesleki Kaygı ve Mesleği Yapma Niyeti İlişkisi
Authors: ÇINAR Burhan , YENİPINAR Uysal
Published: December 2019

Bu çalışmada turist rehberi adaylarının algıladıkları genel öz-yeterlilik, mesleki kaygı ve mesleği yapma niyetleri arasındaki ilişki incelenmektedir. Veriler kolayda örnekleme tekniğine göre turizm rehberliği bölümlerinde öğrenim gören turist rehberi adaylarından anket aracılığıyla toplanmıştır. Verilerin analizinde açıklayıcı faktör analizi ve korelasyon analizinden yararlanılmıştır. Faktör analizi neticesinde turist rehberi adaylarının mesleki kaygılarının sekiz boyut altında, mesleği yapma niyetlerinin iki boyut altında toplandığı tespit edilmiştir. Korelasyon analizi sonuçları, öz-yeterlilik ile mesleki kaygı arasında ters yönlü ve orta düzeyde bir ilişki, öz-yeterlilik ile mesleği yapma niyeti arasında ise pozitif yönlü ve orta düzeyde bir ilişki ve mesleki kaygı ile mesleği yapma niyeti arasında ters yönlü ve zayıf bir ilişki olduğunu göstermektedir. Öz-yeterliliğin, mesleki kaygıdan daha yüksek düzeyde mesleği yapma niyeti ile olan ilişkisi göz önüne alındığında eğitim kurumlarının turist rehberi adaylarını meslek profesyonelleri ile daha fazla bir araya getirmesi onların mesleğe daha iyi hazırlanmasını sağlayacaktır.
Algılanan Hizmetkâr Liderliğin Presentizm (Edimsizlik) Üzerindeki Etkisi: Frigya Bölgesi
Authors: ÖZDEMİR Necip , YILMAZ Esra
Published: December 2019

Presentizm çalışanların sağlık problemleri yaşamalarına rağmen işe gitmelerini ifade etmektedir ve özellikle hizmet işletmelerinde başarısızlığa ve verimliliğin düşmesine neden olmaktadır. Odak noktasında çalışanların ihtiyaçlarının bulunduğu hizmetkâr liderlik anlayışı presentizm kaynaklı verimlilik kayıplarını önleyebilir. Bu doğrultuda araştırmanın amacı, Frigya bölgesinde faaliyet gösteren beş yıldızlı otel işletmelerindeki hizmetkâr liderlik davranışlarının çalışanların presentizm düzeyleri üzerindeki etkisini ortaya koymaktır. Alan araştırmasında nicel yöntem kullanılmış ve veriler anket tekniği ile toplanmıştır. Veri analizinde sıklık, yüzde, korelasyon ve regresyon analizlerinden yararlanılmıştır. Araştırma sonuçlarına göre; Frigya bölgesinde faaliyet gösteren beş yıldızlı otel işletmelerindeki hizmetkâr liderlik davranışlarının çalışanların presentizm düzeylerini negatif yönde etkilediği tespit edilmiştir. Presentizm ile negatif yönde en yüksek düzeyde etkisi olan hizmetkâr liderlik alt boyutu ise güçlendirmedir.
Anti-c-Myc Tag (9E10) Affinity Gel Protocol v2
Authors: Li Sam
Published: December 2019

Catalog Number: 658502 Storage Temperature: 2°C-8°C Product Description: Anti-c-Myc Tag (9E10) Affinity Gel consists of anti-c-myc monoclonal antibody (clone 9E10), covalently immobilized onto 6% high density glyoxal agarose beads. The affinity resin can be used in affinity purifying and immunoprecipitation of c-Myc-tagged fusion protein. Binding Specificity: Mouse monoclonal antibody 9E10 recognizes the c-myc epitope N-EQKLSEEDL-C and is purified through Protein G chromatography. The antibody conjugated affinity resin can bind to epitope at N-terminal, C-terminal, and internal locations of a fusion protein. The binding capacity is greater than 0.5mg per ml of c-myc agarose resin. Reagent: Anti-c-Myc Agarose Affinity Gel is supplied as a 50% suspension in phosphate-buffered saline, pH 7.2, containing 0.09% sodium azide. Precautions and Disclaimer: This product is for research use only. Please consult the Material Safety Data Sheet for information regarding hazards and safe handling practices. Storage/Stability: Anti-c-Myc Agarose Affinity Gel should be stored between 2°C and 8°C for maximum stability. The unopened product is stable for one year when stored as indicated. After use, the resin should be regenerated and stored in TBS or PBS buffer (pH 7.2) containing 0.09% sodium azide.
Dye-terminator DNA sequencing v1
Authors: R Ganguly Diep
Published: December 2019

This protocol (based on the BigDye® Terminator v3.1 Cycle Sequencing Kit) is for performing terminator cycling sequencing reactions for Sanger sequencing of amplified PCR products or plasmid DNA on the 3130X genetic analyser (Applied Biosystems).
Doubting what you already know: uncertainty regarding state transitions is associated with obsessive compulsive symptoms v1
Authors: Fradkin Isaac , Ludwig Casimir , Eldar Eran , D. Huppert Jonathan
Published: December 2019

Obsessive compulsive (OC) symptoms involve excessive information gathering (e.g., checking, reassurance-seeking), and uncertainty about possible, often catastrophic, future events. Here we propose that these phenomena are the result of excessive uncertainty regarding state transitions (i.e. transition uncertainty): a computational impairment in Bayesian inference leading to a reduced ability to use the past to predict the present and future, and to oversensitivity to feedback (i.e. prediction errors). Using a computational model of Bayesian learning under uncertainty in a reversal learning task, we investigate the relationship between OC symptoms and transition uncertainty. Individuals high and low in OC symptoms performed a task in which they had to detect shifts (i.e. transitions) in cue-outcome contingencies. Modeling subjects’ choices was used to estimate each individual participant’s transition uncertainty and associated responses to feedback. We examined both an optimal observer model and an approximate Bayesian model in which participants were assumed to attend (and learn about) only one of several cues on each trial. Results suggested the participants were more likely to distribute attention across cues, in accordance with the optimal observer model. As hypothesized, participants with higher OC symptoms exhibited increased transition uncertainty, as well as a pattern of behavior potentially indicative of a difficulty in relying on learned contingencies, with no evidence for perseverative behavior. Increased transition uncertainty compromised these individuals' ability to predict ensuing feedback, rendering them more surprised by expected outcomes. However, no evidence for excessive belief updating was found. These results highlight a potential computational basis for OC symptoms and obsessive compulsive disorder (OCD). The fact the OC symptoms predicted a decreased reliance on the past rather than perseveration challenges preconceptions of OCD as a disorder of inflexibility. Our results have implications for the understanding of the neurocognitive processes leading to excessive uncertainty and distrust of past experiences in OCD.
Flex-T™ HLA Class I ELISA Protocol v5
Authors: Li Sam
Published: December 2019

The HLA class I ELISA is an enzyme immunoassay based on the detection of β2-microglobulin subunit of HLA class I complexes, after capturing the complex through the conjugated biotin. To this end, biotinylated HLA class I complex is first captured in streptavidin coated microtiter wells. Subsequently, HRP-conjugated anti-human β2- microglobulin is added to detect intact HLA class I complexes. Only intact HLA class I complexes are recognized. Peptides with high affinity binding will be clearly detected by this ELISA technique, while peptides with a moderate to low binding affinity for HLA class I provide a moderate to non-detectable signal. This protocol is designed to evaluate the efficiency of peptide exchange when using the Flex-T™ system.
Discursive representation of authoritarianism in academic communication
Authors: Sapun Tatiana Valeryevna , Kulikova Ludmila Viktorovna
Published: December 2019

The article deals with the discursive category of authoritarianism as one of the typical constants of the prototypical communicative situation, involving the inequality of the participants of the semiotic status-oriented interaction. The article provides an overview of this term in such Humanities as Psychology, Sociology, etc.; the concepts of authority and authoritarianism are differentiated from the perspective of the illocutionary point. The authors give the definition of an authoritarian discourse, the main illocutionary force of which is to exert a psychological pressure on communication partners. The markers of discursive representation of authoritarianism at different semiotic levels within the format of academic communication are analyzed. The key pragmatic characteristics of the academic discourse genres are the asymmetry of the communicative initiative and a teacher`s dominance in communication. The paper concludes that authoritarianism is expressed by a variety of lexical, grammatical, syntactic means at the verbal level (excessive use of professional terminology, modal words with the meaning of obligation, a language game, introductory words with directive connotation, etc.); and by phonation and kinetic means (speech volume and tempo, expressive mimic and gestures) at the nonverbal level. The pragmatic aspect of authoritarian discourse is taken into consideration.
NATIONAL AND SOCIAL IMPERATIVES OF IVAN FRANKO IN THE INTERPRETATION OF LUKA LUTSIV
Authors: Ivanyshyn Petro
Published: December 2019

The article is about the frankoznavchyi experience of one of the most productive researchers of the Ukrainian diaspora, the well-known Ukrainian scientist, journalist and editor Luka Lutsiv (1895-1984). First of all, about his monograph “Ivan Franko is a fighter for national and social justice” (1967). The importance of L. Lutsiv’s work provides not only for a complex illustration of I. Franko’s life and creative work, taking into account various com- plex moments, not only for a simple, lively presentation of the leading ideas, not only for the argumentative refutation of the valuations of the Soviet Franco studies, but also for the use of classical methods of research. The methodological base of his work was biographism (closely related to the cultural-historical approach) and hermeneutics. In the mono- graph we have not only the desire of the researcher to go deep into the artist’s biography and the cultural-historical context of the epoch, but also to protect Franko from the Soviet falsifications and to get to the essence of his creative work – the “truth” (in the terminology of classical philosophy). A literary scholar through the going out of the funda- mental hermeneutic layers understands this “truth”: the deep meanings, values, ideals and imperatives of the writer’s creative work, however, without more concrete terminological definitions. The work is also about the interpretation valuations of L. Lutsiv through the prism of main imperatives, which he identified in Ivan Franko, that is, categorical orders that appear at the same time as the main regulative idea of thinking and the system-forming element of the ideological base of the individual.

The first leading imperative for the researcher is the national imperative (the “ideal of independence”), which re- veals the national-centered (natsiosofskyi, natsionalistychnyi or natsiolohichnyi) component of I. Franko’s worldview. Another central imperative of I. Franko’s life and creative work is the social imperative associated with the problem of social justice. One can state that L. Lutsiv’s monograph, despite all the possible defects, today thanks to the classical methodological base can be positioned not only as a document of the epoch but also as a valuable scientific source, though probably not as academic but as a popular science genre. This study helps to understand I. Franko’s worldview and thinking as a definite integrity, as a complex system and gives significant impulses for the continuation of episte- mological studies of this kind.
The Use of Yoga for Physical and Mental Health Among Older Adults: A Review of the Literature
Authors: Wang Donna
Published: December 2019

The older adult population may greatly benefit from the practice of Yoga. This article reviews the scientific evidence supporting the use of Yoga with older adults. Nine studies were identified that examined either physical or mental health outcomes in older adults following a Yoga intervention. There is growing evidence that Yoga can improve physical well-being, including balance, range of motion, blood pressure, pain, fatigue, and general health. There is less evidence available that examines the cognitive and mental health benefits of Yoga for older adults. However, there is preliminary evidence that Yoga can improve sleep quality and depression. Only three of the reviewed studies were randomized controlled trials, and more studies of high methodological quality are needed. Implications for further research and practice are offered.
Yoga in the Management of Irritable Bowel Syndrome
Authors: Tavassoli Shokufeh
Published: December 2019

Irritable bowel syndrome (IBS) is one of the most common functional gastrointestinal conditions, and conventional medical treatments do not always provide satisfactory relief. There is increasing evidence emerging for the use of psychological approaches in the management of IBS. This review summarizes the evidence for using Yoga in the management of IBS, as well as some possible mechanisms by which Yoga is beneficial for individuals with IBS. Basic Yoga practice recommendations are provided, offering a simple approach that can be easily adopted by individuals with IBS, or by Yoga teachers and healthcare professionals who work with them.
Case of methemoglobinemia in an infant with cyanosis
Authors: Biktimirova Aliya A. , Kamalova Aelita A. , Sabirova Dina R. , Shakirova Almaziya R. , Gayanova Chulpan I. , Saifullina Rezeda M. , Cheminava Lika D. , Fattakhova Ilsina I.
Published: December 2019

Methemoglobinemia refers to a group of hemoglobinopathies which characterized by an increase of the hemoglobin (Hb) amount, in which oxidation of ferrous iron to ferric iron is observed with the loss of the ability to reversibly bond with oxygen and the development of hemic hypoxia. Cyanosis is the most common symptom of methemoglobinemia and is the reason for the differential diagnosis of cardiovascular and respiratory diseases. Timely determination of the cause of cyanosis in a newborn can be a difficult task. By origin, cyanosis in children at birth and in the first weeks of life is cardiac, respiratory, cerebral, metabolic, and hematological. The prognostic value of cyanosis is different for different diseases. Pronounced and persistent cyanosis in diseases of the lungs and heart indicates a high degree of respiratory or heart failure and prognostic unfavorable. Most of the causes of acute cyanosis is an immediate threat to the life of the patient. Prolonged tissue hypoxia in patients with persistent cyanosis leads to the development of secondary erythrocytosis, an hematocrit increase, blood viscosity, which worsens the microcirculation in tissues, aggravating the deficit of tissue respiration. If cyanosis is detected in infants, differential diagnosis should include hemoglobinopathies, in particular, methemoglobinemia. A carefully collected medical history, the exclusion of all possible causes of cyanosis and hypoxemia, and the assessment of methemoglobin in the blood allow a timely diagnosis. The purpose of the article is to describe the clinical observation of methemoglobinemia in an infant with a detailed discussion of the characteristics of the case.
The Impact of Spatial Planning on Development Activity
Authors: Antczak-Stępniak Agata
Published: December 2019

Celem artykułu było zbadanie wpływu planowania przestrzennego na działalność deweloperską na przykładzie wybranych miast Polski. Analiza opisowa literatury przedmiotu, dostępnych danych statystycznych oraz informacji o przedsięwzięciach deweloperskich (samodzielnie zebranych przez autorkę) wykazała znaczne zróżnicowanie w powierzchni miast pokrytej planami oraz w liczbie realizowanych przez deweloperów inwestycji. Co do zasady deweloperzy chętniej prowadzą przedsięwzięcia w miejscu obowiązywania planów miejscowych, lecz zdarzają się też odmienne przypadki, co może wskazywać na błędną politykę gmin w zakresie planowania, zniechęcającą do prowadzenia na jej terenie inwestycji.
Нови изследвания в областта на сравнителната славянска морфология
Authors: Rumenova Margarita
Published: December 2019

Nowe badania w dziedzinie słowiańskiej morfologii porównawczej

Recenzja książek: Стойчев, Стилиян. Българският морфологичен резултатив и чешкият език или за съвременния български морфологичен резултатив и неговите функционални еквиваленти в съвременния чешки език. София: Силует, 2019, 356 стр. ISBN 978-619-194-053-0; Българският морфологичен релатив и чешкият език или за съвременния български морфологичен релатив и неговите функционални еквиваленти в съвременния чешки език. София: Силует, 2019, 405 стр. ISBN 978-619-194-054-7.
Sonnets Fragmented: The Poetics of Disability
Authors: Li Ruth
Published: December 2019

No abstract available.
A Class of Ratio-Type Estimator Using Two Auxiliary Variables for Estimating The Population Mean With Some Known Population Parameters
Authors: Akingbade Toluwalase Janet , Okafor Fabian C.
Published: December 2019

In this paper, we have suggested a class of ratio type estimators with a linear combination using two auxiliary variables with some known population mean of the study variable. The bias and the mean square error of the proposed estimators are derived. We identified sub-members of the class of ratio type estimators. The condition for which the the proposed the proposed estimators perform better than the sample mean per unit, Olkin (1958) multivariate ratio, classical linear regression estimator, Singh(1965), Mohanty (1967) and Swain (2012) are derived. From the analysis, it is observed that the proposed estimators perform better than the sample mean per unit and other existing ratio type estimators considered in this study.
Modified Ratio Estimators of Population Mean Based on Ranked Set Sampling
Authors: Khan Zahid , Ismail Muhammad
Published: December 2019

In this paper, we propose modified ratio estimators using some known values of coefficient of variation, coefficient of skewness and coefficient of kurtosis of auxiliary variable under ranked set sampling (RSS).Â  The mean square error (MSE) of the proposed ratio estimators under ranked set sampling is derived and compared with some existing ratio estimators under RSS. Through this comparison, we prove theoretically that MSC of proposed estimators is less than some existing ratio estimators in RSS under some conditions. The MSE of proposed estimators along with some existing estimator are also calculated numerically. We observe from numerical results that the suggested ratio estimators are more efficient than some existing ratio estimators under RSS.
Weibull Inverse Lomax Distribution
Authors: Hassan Amal S , Mohamed Rokaya E
Published: December 2019

A four-parameter lifetime model, named the Weibull inverse Lomax (WIL) is presented and studied. Some structural properties are derived. The estimation of the model parameters is performed based on Type II censored sample. Maximum likelihood estimators along with asymptotic confidence intervals of population parameters and reliability function are constructed. The property of consistency of maximum likelihood estimators has been verified on the basis of simulated samples. Â Further, the results are applied on two real data.
Bayesian Nonlinear Latent variable Models with Mixed Non-normal Variables and Covariates for Multi-sample Psychological Data
Authors: Y. Thanoon Thanoon , Hamed Athar Talal , Adnan Robiah
Published: December 2019

The purpose of this paper is to develop a latent variable model with nonlinear covariates and latent variables. Mixed ordered categorical and dichotomous variables and covariates with two different types of thresholds (with equal and unequal spaces) are used in Bayesian multi-sample nonlinear latent variable models and the Gibbs sampling method is applied for estimation and model comparison. Hidden continuous normal distribution (censored normal distribution) and (truncated normal distribution with known parameters) are used to handle the problem of mixed ordered categorical and dichotomous data. Hidden continuous normal distribution (truncated normal distribution with known parameters) is used to handle the problem of mixed ordered categorical and dichotomous data in covariates. Statistical analysis, which involves the estimation of parameters, standard deviations and their highest posterior density, are discussed. The proposed procedure is illustrated using psychological data with the results obtained from the OpenBUGS program.
A Family of Loss Distributions with an Application to the Vehicle Insurance Loss Data
Authors: Ahmad Zubair Ahmad , Mahmoudi Eisa Mahmoudi , Hamedani G. G.
Published: December 2019

Actuaries are often in search of nding an adequate loss model in the scenario of actuarial and financial risk management problems. In this work, we propose a new approach to obtain a new class of loss distributions. A special sub-model of the proposed family, called the Weibull-loss model isconsidered in detail. Some mathematical properties are derived and maximum likelihood estimates of the model parameters are obtained. Certain characterizations of the proposed family are also provided. A simulation study is done to evaluate the performance of the maximum likelihood estimators. Finally, an application of the proposed model to the vehicle insurance loss data set is presented.
Fake News, troles y bots
Authors: Cabezas Victor Daniel
Published: December 2019

Este artículo explora las interacciones del derecho humano a la libertad de expresión frente a los trols, bots y fake news. El autor parte por caracterizar la libertad de expresión y delimitar sus alcances genéricos, para luego revisar en qué medida podría proteger estas nuevas manifestaciones derivadas del auge de las tecnologías de la información y comunicación y, en particular, de las redes sociales. Finalmente, se abordan algunas medidas propositivas para dar tratamiento a los aspectos problemáticos derivados de la masificación de los trols, bots y fake news, pues, para el autor, la posibilidad de instaurar una regulación desde el Estado debería ser descartada.
Verificado, un esfuerzo para combatir las noticias falsas
Authors: Padilla Lizbeth
Published: December 2019

Las noticias falsas son un fenómeno que ha crecido exponencialmente con los nuevos canales de difusión de la información, como las redes sociales. De cara a esta realidad, varios medios nativos digitales han creado espacios exclusivos para la verificación de datos con el propósito de combatir la proliferación de información tergiversada, manipulada o falsa. Verificado, la extensión del medio mexicano Animal Político se dedica a la verificación de información y ha creado alianzas con otros medios del país para llevar a cabo el trabajo de hormiga que requiere encontrar y esclarecer la verdad.
“Los datos que interesan son los que cuentan una historia”
Authors: Loor Miguel
Published: December 2019

La verificación de datos en periodismo es un trabajo que genera interés en los debates contemporáneos sobre el rol de los medios en las democracias. Chequeado, un proyecto de  fact-checking de Argentina, es uno de los medios pioneros en la región y el mundo, dedicados a la verificación del discurso público. El periodismo, el diseño, la educación, la tecnología y el trabajo en red pueden combinarse para brindar a la ciudadanía herramientas que le permitan estar más atenta ante la información falsa, como explica Olivia Sohr de Chequeado en esta entrevista.
Women Participation In Organizational Activities In A Democratic Society As Perceived By Stakeholders' In North-West Nigeria
Authors: Halima SARKINFADA , Manir HUSSAINI
Published: December 2019

The study assessed women participation in organizational activities in a democratic society as perceived by stakeholders' in North-West Nigeria. The research design that was used for this study is the descriptive survey design The design allows for the use of questionnaires, which generated valid data that were analyzed. The population of this study consisted of all the stakeholders in education that comprised the students, graduates, teachers, school administrators, Ministry personnel, Quality Assurances officers in the North-west zone of Nigeria. The target population consisted of all stakeholders in the following states: Sokoto, Zamfara, and Kano in the North-west zone of Nigeria.  Multi-stage sampling technique was adopted needed for this study. The total population of stakeholders in North-west Nigeria was 1,970 out of this numbers, 1261 respondents were proportionately selected for the study. Two research questions were raised as follows: (1) What are the stakeholdersperception of the influence of women participation in organizational activities in North-west Nigeria. (2).What are the stakeholdersperception of empowering women to engage in politics an enduring democracy in North-west Nigeria. The findings of this study revealed that more than half of the stakeholders perceived the influence of WCCE graduates on participation in organizational activities in North-west, In addition the result also indicated  that more than half of the stakeholders perceived the contributions of graduates of WCCE to graduates empowerment in politics in North-west,The study recommended that Women were adjudged by the respondents as organizers of homes, and families. Therefore women graduates participation in organization activities in their communities should double their effort so as to continue to serve as a role model to other women in the society for socio-economic development.. NGOs and State government should provide additional support for  women to have access to loans and market facilities. Providing them with soft loans would be required.
Concordancia diagnóstica de la citología, el legrado y la biopsia respecto al estudio histopatológico del espécimen de resección quirúrgica para lesiones premalignas del cérvix en pacientes posmenopáusicas de la ESE Clínica “Maternidad Rafael Calvo” de Cartagena de Indias, Colombia, 2007-2011
Authors: Barrios-García Lía , Contregas-Borrego Eusebio
Published: December 2019

Objetivo: determinar la concordancia diagnóstica de la citología, el legrado endocervical y la biopsia para lesiones premalignas del cérvix en pacientes posmenopáusicas respecto al estudio histopatológico del espécimen de resección quirúrgica.Materiales y métodos: estudio de concordancia diagnóstica de conformidad. A partir de la base de datos del servicio de patología de la ESE Clínica “Maternidad Rafael Calvo”, entidad de referencia en cirugía ginecológica, patología cervical y colposcopia para la población de bajo nivel socioeconómico del régimen de salud subsidiado en Cartagena de Indias, Colombia, entre los años 2007 y 2011, fueron seleccionados todos los reportes de estudios histopatológicos de conización o histerectomía de pacientes mayores de 56 años que documentaran como motivo quirúrgico diagnósticos preoperatorios citológicos o histológicos de lesiones premalignas para valorar su grado de acuerdo mediante el coeficiente Kappa; además, se estimó su valor predictivo positivo (VPP).Resultados: se estudiaron 75 casos con un promedio de 63 años (rango: 57-77), estos corresponden a estudios de resección quirúrgica de 41 conizaciones y 34 histerectomías. La prevalencia de lesiones premalignas o malignas en el estudio histopatológico del espécimen de resección fue del 39%.La concordancia diagnóstica para lesiones premalignas del cérvix en pacientes posmenopáusicas, respecto al estudio histopatológico en espécimen de resección quirúrgica fue: legrado endocervical: 0,056; biopsia: 0,090. La concordancia entre la citología y la patología quirúrgica no fue estimable. El VPP de los hallazgos en estos estudios osciló entre 0 y 52,6%.Conclusión: para el diagnóstico de lesiones cervicales premalignas en pacientes posmenopáusicas la concordancia con el estudio histopatológico del espécimen de resección quirúrgica es leve para estudios histológicos (biopsia y legrado endocervical), siendo mejor en biopsia. El VPP de estos estudios es mejor para lesiones de alto grado respecto a las de bajo grado.
HYGIENIC ASSESSMENT OF X-RAY AND LASER RADIATION AT SURGEONS’ WORKPLACES
Authors: Malkova Natalia Yu. , Baltrukova T. B. , Ivanova O. I. , Petrova M. D.
Published: December 2019

Introduction. Modern surgery is a complex, multifaceted area of medicine that plays an important role in the struggle for health, working capacity and human life. In recent years, in surgery, much attention has been paid to the improvement and development of new surgical equipment, including that based on ionizing and non-ionizing radiation, its application range being widened, which allows patients being provided with high-tech and less traumatic procedures. However, the use of such equipment resulted in the appearance of new adverse occupational factors of ionizing and non-ionizing nature at the workplaces of surgical team members, which can have a negative effect on the personnel. Material and methods. Data of x-ray and laser radiation level studies at the workplaces of medical personnel in modern operating rooms are reported. Results. Total normalized power of the effective x-ray dose during the use of x-ray surgical unit at the workplaces of surgical teams in most cases was revealed not to exceed allowable dose rate, while in the process of certain procedures, such as vessel embolization, it can exceed allowable levels. The total annual effective radiation exposure dose of x-ray surgery teams depends on the number of performed operations, their type, complexity, and can exceed a basic radiation dose limit for A and B group personnel. The intensity of diffusely reflected laser radiation at workplaces of surgeons can significantly exceed maximum allowable levels, sometimes up to 600 times. Discussion. Considering an ever-gaining use of high-tech equipment generating laser and X-ray radiation and increasing number of exposed medical personnel, hygienic assessment of these radiation levels at workplaces of surgical team members and development of measures to improve working conditions is an important issue for maintaining workers’ health. Conclusion. To assess the occupational risk degree to the health of surgeons it is necessary to conduct in-depth studies of their health status.
SELF-ASSESSMENT OF OCCUPATIONAL STRESS AND WORKABILITY IN THE IMPLEMENTATION OF THE WORLD HEALTH ORGANIZATION’S GLOBAL STRATEGY “HEALTH FOR ALL” AT THE WORKPLACE LEVEL IN MODERN MACHINERY COMPANIES
Authors: Lachein B. . , Chashchin Valerii P. , Zhukova D. Yu. , Korzinina I. A.
Published: December 2019

Introduction. The WHO “Health for All” strategy is implementing a transition from the paradigm of pathogenesis to salutogenesis, aimed at maintaining and promoting the health of the population provided in the field of work by modern forms and methods of the health and safety of personnel. Material and methods. The studies were carried out at the enterprise of a high-tech machine-building complex for the production of gas turbines and included the evaluation of occupational stress, stress tolerance and health index in 4 occupational groups by using questionnaire survey methods. 144 employees including 94 men and 50 women aged from 26 to 45 years, who have worked at the enterprise for at least one year, are invited to take part in the study. Results. A multi-level regression model for assessing occupational stress showed psycho-physiological, motivational, informational and behavioral factors to determine the level of stress by an average of 72.3 ± 2.6%, and a decrease in the workability index by 59.6 ± 4.6%. One of the results of the program implemented is a higher motivation of employees to participate consciously in the health protection and promotion activities at the workplace level (92%). Discussion. The conceptualization of occupational stress and workability is a prerequisite for the development of health protection and promotion at the workplace level, especially in the case of intellectual work. These indices can be used as predictors for determining the risk of early dismissal, premature aging, and professional longevity, as well as in assessing the quality of life of workers. Conclusion. Evaluation and management of occupational stress, maintaining high workability and creating sustainable motivation of employees to participate in health programs is one of the tools of the health promotion policy at the workplace level and the extension of the occupational longevity of the working population, which corresponds to the main goals of the Russian National Demography Project.
MODES OF USE OF THE CELL PHONE AND HEALTH OF SCHOOLCHILDREN
Authors: Vyatleva Olga A. , Kurgansky A. M.
Published: December 2019

Introduction. The broad spread of cell phones (CP) among schoolchildren and the absence of age standards for their safe use determined the purpose of the study: to reveal the regimens of CP use, critical for the health of children and adolescents. Material and methods. In a cross-sectional study in 2008-2010, by the questionnaire data of 2,137 schoolchildren aged 6-15 years there was assessed the impact of CP usage indices (daily number of calls - CN, call duration - CD, and total daily duration of calls - TCDD) on health (the incidence of headaches and sleep disorders, number of colds). Student and Mann-Whitney criteria and assessment of relative risks were used. Results. The study revealed age-dependent critical values of usage indices (in 6-10 years: CN=2, TCDD=6 minutes.; in 11-13 years: CN=6; in 14-15 years CN=6, CD=3 minutes., TCDD=4 -10 min.), the exceeding of which due to risks: in 6-10 years - to have more than 4 colds a year (OR 2.25, 95% CI 1.09-4.62); in 11-13 years to have several headaches per week (OR 1.61, 95% CI 1.12-2.30); in 14-15 years - to have several headaches (OR 1.79, 95% CI 1.27-2.54) and several sleep disorders (OR 1.66, 95% CI 1.17-2.37) per week. Discussion. Age differences in critical modes of CP use and in health violations, as well as the importance of radiation intensity are discussed. Conclusions. Age-related CP use regimens, critical for health, were established. It was shown the need to develop more precise age criteria for safe CP use with taking into account a wider range of health indicators and radiation intensity.
Metabolic Stability of New Mito-Protective Short-Chain Naphthoquinones
Authors: Feng Zikai , Smith Jason A. , Gueven Nuri , Quirino Joselito P.
Published: December 2019

Short chain quinones (SCQs) have been identified as potential drug candidates against mitochondrial dysfunction, which is largely dependent on their reversible redox characteristics of the active quinone core. We recently synthesized a SCQ library of > 148 naphthoquinone derivatives and identified 16 compounds with enhanced cytoprotection compared to the clinically used benzoquinone idebenone. One of the major drawbacks of idebenone is its high metabolic conversion in the liver, which significantly restricts is therapeutic activity. Therefore, this study assessed the metabolic stability of the 16 identified naphthoquinone derivatives 1-16 using hepatocarcinoma cells in combination with an optimized reverse-phase liquid chromatography (RP-LC) method. Most of the derivatives showed significantly better stability than idebenone over 6 hours (p < 0.001). By extending the side-chain of SCQs, increased stability for some compounds was observed. Metabolic conversion from the derivative 3 to 5 and reduced idebenone metabolism in the presence of 5 were also observed. These results highlight the therapeutic potential of naphthoquinone-based SCQs and provide essential insights for future drug design, prodrug therapy and polytherapy, respectively.
GDNF, a Neuron-derived Factor Upregulated in Glial Cells during Disease
Authors: Duarte Azevedo Marcelo , Sander Sibilla , Tenenbaum Liliane
Published: December 2019

In healthy adult brain, glial cell line-derived neurotrophic factor (GDNF) is exclusively expressed by neurons and in some instances, it has furthermore been shown to derive from a single neuronal subpopulation. Secreted GDNF acts in a paracrine fashion by forming a complex with GDNF family receptor α1 (GFRα1) which is mainly expressed by neurons and can act in cis as a membrane-bound or in trans as a soluble factor. The GDNF/GFRα1 complex signals through interaction with RET (“rearranged during transfection”) or with a lower affinity with neural cell adhesion molecule (NCAM). GDNF can also signal independently from GFRα1 via interaction with syndecan-3. RET being expressed by neurons involved in several pathways: nigro-striatal dopaminergic neurons, motor neurons, enteric neurons, sensory neurons, etc. could be the main determinant of the specificity of GDNF pro-survival effect. In injured brain, de novo expression of GDNF occurs in glial cells. Neuroinflammation has been reported to induce GDNF expression in activated astrocytes and microglia, infiltrating macrophages, nestin-positive neural stem cells and neuron/glia (NG2) progenitors. This disease-related GDNF overexpression can be either beneficial or detrimental depending on the localization in the brain and the level and duration of glial cells activation. Some reports also describe upregulation of RET and GFRα1 in glial cells, suggesting that GDNF could modulate neuroinflammation.