bluuebunny/crossref_metadata_2025 huggingface dataset:
Italian Men Tested for BRCA1/2 Mutation: Psychological Distress during 6-Month Follow-Up
Authors: Pellini F. , Mirandola S. , Granuzzo E. , Urbani S. , Piccinni Leopardi G. , Pollini G. P.
Published: January 2020

Introduction. Male breast cancer (MBC) is a rare disease, whose main risk factor is genetic vulnerability. Despite care of men with MBC is modeled on care of women, men’s experiences with the disease and concerns related to the status of genetic mutation carrier are unique. So far, little is known concerning the psychological impact in BRCA1/2 testing, especially with regard to specific subset of individuals, such as male subjects and the elderly. Methods. We assessed self-reported anxiety and depression levels in 26 male subjects presenting at Unit of Breast Surgery in Breast Unit of AOUI Verona (MBC patients, n = 7; high-risk unaffected subjects, n = 19). We specifically examined the scores obtained by these subjects in the HADS questionnaire administered before and 6 months after the genetic testing for BRCA gene mutations. Results. Among the 17 unaffected men tested, 7 (41%) received a positive test (either BRCA1 or BRCA2 pathogenic variant) and 10 (59%) a negative test. Of the 9 MBC patients tested, only one subject received a positive test result. No significant differences were observed in mean scores, mean change from baseline to follow-up, either for those with T+ or T− test results. Discussion. Genetic testing for BRCA1/2 mutation was not associated in our sample with increased level of psychological distress as measured with HADS in a short-term evaluation.
A Modified Analytical Heat Source Model for Numerical Simulation of Temperature Field in Friction Stir Welding
Authors: Liu Xiangqian , Yu Yan , Yang Shengli , Liu Huijie
Published: January 2020

In the conventional analytical model used for heat generation in friction stir welding (FSW), the heat generated at the pin/workpiece interface is assumed to distribute uniformly in the pin volume, and the heat flux is applied as volume heat. Besides, the tilt angle of the tool is assumed to be zero for simplicity. These assumptions bring about simulating deviation to some extent. To better understand the physical nature of heat generation, a modified analytical model, in which the nonuniform volumetric heat flux and the tilt angle of the tool were considered, was developed. Two analytical models are then implemented in the FEM software to analyze the temperature fields in the plunge and traverse stage during FSW of AA6005A‐T6 aluminum hollow extrusions. The temperature distributions including the maximum temperature and heating rate between the two models are different. The thermal cycles in different zones further revealed that the peak temperature and temperature gradient are very different in the high‐temperature region. Comparison shows that the modified analytical model is accurate enough for predicting the thermal cycles and peak temperatures, and the corresponding simulating precision is higher than that of the conventional analytical model.
Asynchronous Injection-Production Process: A Method to Improve Water Flooding Recovery in Complex Fault Block Reservoirs
Authors: Yuan Shibao , Wang Rui , Jiang Haiyan , Xie Qing , Chen Shengnan , Xu Bo , Li Lehong , Zhang Yupeng
Published: January 2020

The complex fault block reservoir has the characteristics of small area and many layers in vertical. Due to the influence of formation heterogeneity and well pattern, the situation that “water fingering is serious with water injection, on the contrary, driving energy is low” frequently occurs in water flooding, which makes it difficult to enhance oil recovery. Asynchronous injection-production (AIP) process divides the conventional continuous injection-production process into two independent processes: injection stage and production stage. In order to study oil recovery in the fault block reservoir by AIP technology, a triangle closed block reservoir is divided into 7 subareas. The result of numerical simulation indicates that all subareas have the characteristic of fluid diverting and remaining oil in the central area is also affected by injected water at injection stage of AIP technology. Remaining oil in the central area is driven to the included angle and border area by injected water and then produced at the production stage. Finally, the oil recovery in the central area rises by 5.2% and in the noncentral area is also increased in different levels. The AIP process can realize the alternative change of reservoir pressure, change the distribution of flow field, and enlarge the swept area by injected water. To sum it up, the AIP process is an effective method to improve the oil recovery in complex fault-block reservoir by water flooding.
Feasibility of Attachable Ring Stimulator for Intraoperative Neuromonitoring during Thyroid Surgery
Authors: Kim Jongjin , Moon Hyeon Jong , Chai Young Jun , Lee Jung-Man , Hwang Ki-Tae , Wu Che-Wei , Dionigi Gianlorenzo , Kim Hoon Yub , Park Kyung Sik , Kim Sang Wan , Yi Ka Hee
Published: January 2020

Objective. Stimulator-attached dissecting instruments are useful for intraoperative nerve monitoring during thyroidectomy. The aim of this study was to evaluate the feasibility of an attachable ring stimulator (ARS) by comparing the electromyography (EMG) amplitudes evoked by an ARS and a conventional stimulator. Methods. Medical records of fourteen patients who underwent thyroidectomy using intraoperative neuromonitoring between June and August 2019 were retrospectively reviewed. The amplitudes of V1, R1, R2, and V2 signals were checked using both the ARS and a conventional stimulator, at the same point. Results. Both stimulators were tested on 20 recurrent laryngeal nerves (RLNs) and 20 vagus nerves (VNs). In all the nerves, the amplitudes of V1, R1, R2, and V2 were greater than 500 μV. The mean amplitudes of V1, R1, R2, and V2 checked with the ARS were 1175, 1432, 1598, and 1279 μV, respectively. The mean amplitudes of V1, R1, R2, and V2 checked with the conventional stimulator were 1140, 1425, 1557, and 1217 μV, respectively. Difference between amplitudes evoked by the two stimulators for V1, R1, R2, and V2 was 77, 110, 102, and 99 μV, respectively. There was no statistical difference in the amplitudes between the two groups for V1, R1, R2, and V2. Conclusion. The ARS transferred electric stimulation as effectively as the conventional stimulator. It is an effective tool for repeated stimulation and facilitates continuous feedback regarding the functional integrity of nerves during thyroid surgery.
Influence of the Curvature of the Multipoint Die for Flexible Multipoint Stretch Bending on the Quality of Aluminum Profile
Authors: Li Yi , Li Rui , Liang Ce , Liang Jicai , Teng Fei
Published: January 2020

The finite element numerical simulation method was used to study the stretch-bending process of asymmetric L-section aluminum alloy profiles. The geometrical parameters of the multipoint dies (MPDs) are studied to influence the shape accuracy and springback of the L-section profile after bending. The results show that the profile curvature of the MPD after the profile is bent has a great influence on the stress-strain distribution, springback value, and shape accuracy. In order to obtain uniform stress-strain of the profile and reduce the springback and shape error, the MPD is optimized by numerical simulation analysis, which has a certain reference value of providing a theoretical basis for the rational design of the flexible stretch-bending.
Slicing Resource Allocation for eMBB and URLLC in 5G RAN
Authors: Ma Tengteng , Zhang Yong , Wang Fanggang , Wang Dong , Guo Da
Published: January 2020

This paper investigates the network slicing in the virtualized wireless network. We consider a downlink orthogonal frequency division multiple access system in which physical resources of base stations are virtualized and divided into enhanced mobile broadband (eMBB) and ultrareliable low latency communication (URLLC) slices. We take the network slicing technology to solve the problems of network spectral efficiency and URLLC reliability. A mixed-integer programming problem is formulated by maximizing the spectral efficiency of the system in the constraint of users’ requirements for two slices, i.e., the requirement of the eMBB slice and the requirement of the URLLC slice with a high probability for each user. By transforming and relaxing integer variables, the original problem is approximated to a convex optimization problem. Then, we combine the objective function and the constraint conditions through dual variables to form an augmented Lagrangian function, and the optimal solution of this function is the upper bound of the original problem. In addition, we propose a resource allocation algorithm that allocates the network slicing by applying the Powell–Hestenes–Rockafellar method and the branch and bound method, obtaining the optimal solution. The simulation results show that the proposed resource allocation algorithm can significantly improve the spectral efficiency of the system and URLLC reliability, compared with the adaptive particle swarm optimization (APSO), the equal power allocation (EPA), and the equal subcarrier allocation (ESA) algorithm. Furthermore, we analyze the spectral efficiency of the proposed algorithm with the users’ requirements change of two slices and get better spectral efficiency performance.
The Functional Severity Assessment of Coronary Stenosis Using Coronary Computed Tomography Angiography-Based Myocardial Mass at Risk and Minimal Lumen Diameter
Authors: Sadamatsu Kenji , Nagaoka Kazuhiro , Koga Yasuaki , Kagiyama Kotaro , Muramatsu Kohei , Hironaga Kiyoshi , Tashiro Hideki , Ueno Takafumi , Fukumoto Yoshihiro
Published: January 2020

Background. We investigated whether or not the addition of myocardial mass at risk (MMAR) to quantitative coronary angiography was useful for diagnosing functionally significant coronary stenosis in the daily practice. Methods. We retrospectively enrolled 111 consecutive patients with 149 lesions who underwent clinically indicated coronary computed tomography angiography and subsequent elective coronary angiography with fractional flow reserve (FFR) measurement. MMAR was calculated using a workstation-based software program with ordinary thin slice images acquired for the computed tomography, and the minimal lumen diameter (MLD) and the diameter stenosis were measured with quantitative coronary angiography. Results. The MLD and MMAR were significantly correlated with the FFR, and the MMAR-to-MLD ratio (MMAR/MLD) showed a good correlation. The area under the receiver operating characteristic curve (AUC) of MMAR/MLD for FFR ≤ 0.8 was 0.746, and the sensitivity, specificity, positive predictive value, and negative predictive value were 60%, 83%, 68%, and 77%, respectively, at a cut-off value of 29.5 ml/mm. The addition of MMAR/MLD to diameter stenosis thus made it possible to further discriminate lesions with FFR ≤ 0.8 (AUC = 0.750). For the proximal left coronary artery lesions, in particular, MMAR/MLD showed a better correlation with the FFR, and the AUC of MMAR/MLD for FFR ≤ 0.8 was 0.919 at a cut-off value of 31.7 ml/mm. Conclusions. The index of MMAR/MLD correlated well with the physiological severity of coronary stenosis and showed good accuracy for detecting functional significance. The MMAR/MLD might be a useful parameter to consider when deciding the indication for revascularization.
A Deterministic Model for Q Fever Transmission Dynamics within Dairy Cattle Herds: Using Sensitivity Analysis and Optimal Controls
Authors: Asamoah Joshua Kiddy K. , Jin Zhen , Sun Gui-Quan , Li Michael Y.
Published: January 2020

This paper presents a differential equation model which describes a possible transmission route for Q fever dynamics in cattle herds. The model seeks to ascertain epidemiological and theoretical inferences in understanding how to avert an outbreak of Q fever in dairy cattle herds (livestock). To prove the stability of the model’s equilibria, we use a matrix-theoretic method and a Lyapunov function which establishes the local and global asymptotic behaviour of the model. We introduce time-dependent vaccination, environmental hygiene, and culling and then solve for optimal strategies. The optimal control strategies are necessary management practices that may increase animal health in a Coxiella burnetii-induced environment and may also reduce the transmission of the disease from livestock into the human population. The sensitivity analysis presents the relative importance of the various generic parameters in the model. We hope that the description of the results and the optimality trajectories provides some guidelines for animal owners and veterinary officers on how to effectively minimize the bacteria and control cost before/during an outbreak.
Research Progress on Tumor‐Associated Macrophages and Inflammation in Cervical Cancer
Authors: Liu Yi , Li Li , Li Ying , Zhao Xia
Published: January 2020

Cervical cancer is the most common gynecological tumor worldwide. Persistent infection of high‐risk HPV‐induced smouldering inflammation is considered to be an important risk factor for cervical cancer. The tumor microenvironment (TME) plays an important role in the progress of the tumor occurrence, development, and prognosis of cervical cancer. Macrophages are the main contributor to the TME, which is called tumor‐associated macrophages (TAMs). During the inflammatory response, the phenotype and function of TAMs are constantly changing, which are involved in different regulatory networks. The phenotype of TAMs is related to the metabolism and secretory factors release, which facilitate the angiogenesis and lymphatic duct formation during cervical cancer metastasis, thus affecting the prognosis of cervical cancer. This review intends to discuss the recent research progress on the relationship between TAMs and cervical cancer, which is helpful to elucidate the mechanism of TAMs in cervical cancer.
Role of Oxycodone Hydrochloride in Treating Radiotherapy-Related Pain
Authors: Wang Yinxia , Xing Ligang
Published: January 2020

Radiotherapy is commonly used to treat cancer patients. Besides the curable effect, radiotherapy also could relieve the pain of cancer patients. However, cancer pain is gradually alleviated about two weeks after radiotherapy. In addition, cancer patients who receive radiotherapy may also suffer from pain flare or radiotherapy-induced side effects such as radiation esophagitis, enteritis, and mucositis. Pain control is reported to be inadequate during the whole course of radiotherapy (before, during, and after radiotherapy), and quality of life is seriously affected. Hence, radiotherapy is suggested to be combined with analgesic drugs in clinical guidelines. Previous studies have shown that radiotherapy combined with oxycodone hydrochloride can effectively alleviate cancer pain. In this review, we firstly presented the necessity of analgesia during the whole course of radiotherapy. We also sketched the role of oxycodone hydrochloride in radiotherapy of bone metastases and radiotherapy-induced oral mucositis. Finally, we concluded that oxycodone hydrochloride shows good efficacy and tolerance and could be used for pain management before, during, and after radiotherapy.
Macroscopic and Microscopic Characterization of the Effect of “Activation” Process on the Performance of Buton Rock Asphalt‐Modified Asphalt
Authors: Li Yafei , Guo Meng , Liu Xu
Published: January 2020

In the process of using Buton rock asphalt‐ (BRA‐) modified asphalt, in order to improve the utilization rate of Buton rock asphalt and the performance of the modified asphalt, this paper puts forward the process of “activation” treatment of Buton rock asphalt, that is, grinding and heating of BRA to make natural asphalt precipitate. Laboratory tests show that compared with modified asphalt without activation process, the penetration of the modified asphalt decreases, the softening point rises, the ductility at 5°C and the kinematic viscosity at 135°C all have been increased, and the performance of the modified asphalt increases with the increase of the content of activated BRA. In order to further clarify the effect of “activation” process on the properties of BRA‐modified asphalt from microlevel, atomic force microscopy (AFM) was used to test the microproperties of Buton rock asphalt before and after activation. It is found that the Derjaguin–Muller–Toporov (DMT) modulus of the modified asphalt is about 2.5 times that of base asphalt, which indicates that the viscous degree of modified asphalt with activated BRA has been greatly increased and the modification effect is remarkable.
The Performance of Squeeze Film between Parallel Triangular Plates with a Ferro-Fluid Couple Stress Lubricant
Authors: Toloian Akbar , Daliri Maghsood , Javani Nader
Published: January 2020

The present study aims at investigating a couple stress ferrofluid lubricant effects on the performance of the squeezed film when a uniform external magnetic field is applied. For this purpose, Shliomis ferrohydrodynamic and couple stress fluid models are employed. The considered geometry is parallel triangular plates. The effects of couple stress, volume concentration, and Langevin parameters on squeeze film characteristics including time vs. height relationship and load-carrying capacity are investigated. According to the results, employing couple stress ferrofluid lubricant in the presence of the magnetic field leads to an increased performance of the squeeze film.
Endoscopic Ultrasound in Guiding Local Resection and Ampullary Preservation of a High-Risk Periampullary GIST
Authors: Spiel Andrew , Patel Ravi , Minter Rebecca , Rahnemai Azar Amir Ali , Agni Rashmi , Bosch Antonio , Gopal Deepak
Published: January 2020

Gastrointestinal stromal tumors (GISTs) typically develop in the stomach or small intestine and rarely involve the ampulla of Vater, with only 13 cases reported in the world literature since 2004. Most authors advocate performing pancreaticoduodenectomy for such lesions. However, this operation can carry higher rates of morbidity and mortality compared to local resection. We present a case of a high-risk, invasive periampullary GIST and the multidisciplinary management approach to local resection with the aid of endoscopic ultrasound. In addition, this case shows no local recurrence at 3 months and a favorable clinical outcome at 1 year.
Left Lower Lung Collapse in a Patient Undergoing Endoscopic Procedure
Authors: Kamath Akshatha , Yarmush Joel , Rao Sneha
Published: January 2020

ASA closed claims from 2000 to 2009 have shown that adverse respiratory events are more common in nonoperating room locations like endoscopy suite than in the operating room (44% v/s 20%). Here, we report a case of lung atelectasis which resulted in hypoxemia in a malnourished patient undergoing endoscopic procedure. It is crucial to identify the high-risk patients and monitor them appropriately in the postoperative phase. Continuous capnometry may offer additional benefit by identifying hypercapnia, hypoventilation at the earliest in the recovery area, thus preventing serious complications.
Multiperspective Light Field Reconstruction Method via Transfer Reinforcement Learning
Authors: Cai Lei , Luo Peien , Zhou Guangfu , Xu Tao , Chen Zhenxue
Published: January 2020

Compared with traditional imaging, the light field contains more comprehensive image information and higher image quality. However, the available data for light field reconstruction are limited, and the repeated calculation of data seriously affects the accuracy and the real-time performance of multiperspective light field reconstruction. To solve the problems, this paper proposes a multiperspective light field reconstruction method based on transfer reinforcement learning. Firstly, the similarity measurement model is established. According to the similarity threshold of the source domain and the target domain, the reinforcement learning model or the feature transfer learning model is autonomously selected. Secondly, the reinforcement learning model is established. The model uses multiagent (i.e., multiperspective) Q-learning to learn the feature set that is most similar to the target domain and the source domain and feeds it back to the source domain. This model increases the capacity of the source-domain samples and improves the accuracy of light field reconstruction. Finally, the feature transfer learning model is established. The model uses PCA to obtain the maximum embedding space of source-domain and target-domain features and maps similar features to a new space for label data migration. This model solves the problems of multiperspective data redundancy and repeated calculations and improves the real-time performance of maneuvering target recognition. Extensive experiments on PASCAL VOC datasets demonstrate the effectiveness of the proposed algorithm against the existing algorithms.
FDA Approval Summary: Atezolizumab Plus Paclitaxel Protein-bound for the Treatment of Patients with Advanced or Metastatic TNBC Whose Tumors Express PD-L1
Authors: Narayan Preeti , Wahby Sakar , Gao Jennifer J. , Amiri-Kordestani Laleh , Ibrahim Amna , Bloomquist Erik , Tang Shenghui , Xu Yuan , Liu Jiang , Fu Wentao , Song Pengfei , King-Kallimanis Bellinda L. , Hou Sherry , Gong Yutao , Kalavar Shyam , Ghosh Soma , Philip Reena , Goldberg Kirsten B. , Theoret Marc R. , Blumenthal Gideon M. , Kluetz Paul G. , Sridhara Rajeshwari , Pazdur Richard , Beaver Julia A.
Published: January 2020

On March 8, 2019, the FDA granted accelerated approval to atezolizumab in combination with paclitaxel protein-bound for the treatment of adult patients with unresectable locally advanced or metastatic triple-negative breast cancer (TNBC) whose tumors express PD-L1 [PD-L1 stained tumor-infiltrating immune cells (IC) of any intensity covering ≥1% of the tumor area], as determined by an FDA-approved test. Approval was based on data from IMpassion130, which randomized patients to receive atezolizumab or placebo in combination with paclitaxel protein-bound. Investigator-assessed progression-free survival (PFS) in the intent-to-treat (ITT) and PD-L1–positive populations were coprimary endpoints. After 13-month median follow-up, the estimated median PFS in the PD-L1–positive population was 7.4 months in the atezolizumab arm and 4.8 months in the placebo arm [HR = 0.60; 95% confidence interval (CI), 0.48–0.77]. Overall survival (OS) results were immature with 43% deaths in the ITT population, representing 59% of the OS events required to perform the final OS analysis. Adverse reactions occurring in ≥20% of patients receiving atezolizumab with paclitaxel protein-bound were alopecia, peripheral neuropathies, fatigue, nausea, diarrhea, anemia, constipation, cough, headache, neutropenia, vomiting, and decreased appetite. Accelerated approval was appropriate taking into account the unmet medical need along with the immaturity of the OS results and potential for PFS in the PD-L1–expressing population to predict clinical benefit.
Achieving Opioid-Free Major Colorectal Surgery: Is It Possible?
Authors: Yap Raymond , Nassif George , Hwang Grace , Mendez Alvardo , Erkan Arman , Kelly Justin , Debeche-Adams Teresa , Albert Matthew , Monson John
Published: January 2020

Introduction: Opioid analgesia remains the mainstay of postoperative pain management strategies despite being associated with many adverse effects. A specific opioid-free protocol was designed to limit opioid usage. Objective: The aim of the study was to audit the opioid-free rate within this protocol and to identify factors that might contribute to opioid-free surgery. Methods: A retrospective study of all elective patients receiving abdominal colorectal surgery at the Center for Colon and Rectal Surgery at AdventHealth over 6 months was performed. Data on demographics, indications, perioperative management, outcomes, and inpatient and outpatient analgesic requirements were collected with subsequent analysis. Results: A total of 303 consecutive patient records were analyzed. Approximately two-thirds (67.7%) of patients did not receive narcotics once they left the postanesthesia care unit as an inpatient. One-third of patients (32.0%) did not receive narcotic analgesia within 30 days of surgery as an outpatient. Patients in the opioid-free cohort were significantly older and had a malignant indication, less perioperative morbidity, and a shorter length of stay. Conclusions: Our study demonstrates that opioid-free analgesia is indeed possible in major colorectal surgery. Study limitations include its retrospective nature and that it is from a single institution. Despite these limitations, this study provides proof of concept that opioid-free colorectal surgery is possible within a specific protocol.
Success of Face Analysis Technology in Rare Genetic Diseases Diagnosed by Whole-Exome Sequencing: A Single-Center Experience
Authors: Elmas Muhsin , Gogus Basak
Published: January 2020

The diagnosis of rare genetic diseases is one of the most difficult areas in medicine. Whole-exome sequencing (WES) technology makes it easier to diagnose these diseases. In addition, next-generation phenotyping can help to diagnose computer-based algorithms. Detailed dysmorphologic findings of 25 patients diagnosed by WES in our center were described. The success of this technology in diagnosing rare genetic diseases was investigated by scanning the photographs of 25 patients with Face2Gene application. The application listed possible preliminary diagnoses (30 disease suggestion). Of these, 12 (48%) cases were correctly matched. The most common disease group in the patients was neurological disease (96%). The most common mode of inheritance in the patients was autosomal recessive. The rate of consanguineous marriages was determined in 80% of the patients. Ten patients had microcephaly and 7 patients had corpus callosum anomaly. In our study, we found that the success of Face2Gene was lower than described in the literature. We think that the probable cause of this condition is that the cases are very rare, and there is not enough data about these diseases in the application. Therefore, it is recommended that applications should be used more frequently by pediatricians and clinical geneticists. The diagnosis of rare diseases still is quite difficult. Nowadays, WES is a successful method. However, applications such as Face2Gene help to make a clinical prediagnosis and create a larger database.
Faces da utopia: inferno ou paraíso?
Authors:   Universidade do Minho, Instituto de Educação, Araújo Alberto Filipe , Araújo Joaquim Machado de ,   Universidade Católica Portuguesa, Faculdade de Educação e Psicologia, Almeida Rogério de ,   Universidade de São Paulo, Faculdade de Educação
Published: January 2020

O livro aborda três faces da palavra "utopia" . É importante ressaltar, segundo os autores, que quando usada na oralidade ou na escrita, a palavra utopia suscita ressonâncias distintas no ouvinte ou leitor, nem sempre coincidentes com o sentido que lhe é atribuído por quem a pronuncia ou escreve. Em seu conjunto, os três textos que compõem a obra dão conta de um modo de tratamento contraditório da complexidade do fenômeno utópico, embora se atendo a dimensões distintas. Alberto Filipe Araújo, a partir dos estudos do imaginário, põe em evidência traços da ilha e da cidade utópicas imaginadas por Tomas More - filósofo e advogado, autor do clássico Utopia -, que fazem delas expressão do "mito do paraíso". Joaquim Machado de Araújo, no capítulo "Faces da utopia - Esperança e responsabilidade de um mundo melhor", realça algumas caraterísticas da cidade utópica descrita por More como sendo discutíveis já para o próprio autor e que vieram a ser glosadas em muitas narrativas que, na modernidade, mostram a face negativa das utopias. Finalizando, no terceiro capítulo, Rogério de Almeida em "Utopia e distopia no imaginário cinematográfico contemporâneo", ancora a abordagem ao cinema em seus fundamentos educativos (o cognitivo, o filosófico, o estético, o mítico, o existencial, o antropológico e o poético).
Wnt Pathway Gene Expression Is Associated With Arterial Stiffness
Authors: Kuipers Allison L. , Miljkovic Iva , Barinas‐Mitchell Emma , Nestlerode Cara S. , Cvejkus Ryan K. , Wheeler Victor W. , Zhang Yingze , Zmuda Joseph M.
Published: January 2020

Background

Animal and in vitro experiments implicate the Wnt pathway in cardiac development, fibrosis, vascular calcification, and atherosclerosis, but research in humans is lacking. We examined peripheral blood Wnt pathway gene expression and arterial stiffness in 369 healthy African ancestry men (mean age, 64 years).

Methods and Results

Gene expression was assessed using a custom Nanostring
nC
ounter gene expression panel (N=43 genes) and normalized to housekeeping genes and background signal. Arterial stiffness was assessed via brachial‐ankle pulse‐wave velocity. Fourteen Wnt genes showed detectable expression and were tested individually as predictors of pulse‐wave velocity using linear regression, adjusting for age, height, weight, blood pressure, medication use, resting heart rate, current smoking, alcohol intake, and sedentary lifestyle. Adenomatous polyposis coli regulator of Wnt signaling pathway (

APC

), glycogen synthase kinase 3β (

GSK
3B

), and transcription factor 4 (

TCF
4

) were significantly associated with arterial stiffness (
P
<0.05 for all). When entered into a single model,

APC

and

TCF
4

expression remained independently associated with arterial stiffness (
P
=0.04 and 0.003, respectively), and each explained ≈3% of the variance in pulse‐wave velocity.

Conclusions

The current study establishes a novel association between in vivo expression of the Wnt pathway genes,

APC

and

TCF
4

, with arterial stiffness in African ancestry men, a population at high risk of hypertensive vascular disease.
Shrinking biodiversity, dwindling taxonomy and building a broader science
Authors: BORKENT ART
Published: January 2020

In proposing what might be the three leading questions in taxonomy, I have thought primarily about what might be the biggest barriers to taxonomists accurately describing the species on our planet and interpreting their phylogenetic relationships within a historical context. I have generally used the vernacular and examples of issues which I know as a dipterist (fly taxonomist). I apologize to my colleagues working on other groups but hope to be pardoned in the recognition that the problems identified below do appear to apply to our broader taxonomic community. 1. What are the impacts of the rapid rate of present day extinctions? 2. What is the future for taxonomists themselves? 3. What are some of the impacts of technology?
Integrative description of two new Cratena species (Mollusca: Nudibranchia) from western India
Authors: BHARATE MONISHA , PADULA VINICIUS , APTE DEEPAK , SHIMPI GAURAV G.
Published: January 2020

Among the Facelinidae, the genus Cratena comprises nine valid species, four of them presenting a similar colour pattern with white body, reddish diverticula in the cerata and a pair of orange spots laterally on the head. Based on an integrative molecular phylogenetic and morphological approach two new species from western India are described, Cratena poshitraensis sp. nov. and Cratena pawarshindeorum sp. nov. Both species are similar to C. peregrina and C. minor but differ in body length, shape and size of orange spots on the head, C. poshitraensis sp. nov. presenting narrow spots dorsally projected on the base of each oral tentacle while C. pawarshindeorum sp. nov. has large and conspicuous orange spots that embrace dorsally and ventrally the base of the oral tentacles. According to our phylogenetic analysis, Facelina turned out paraphyletic and Cratena polyphyletic with an unclear relationship to Myja and Facelinidae sp.2, and Cratena pilata clustering distant to other Cratena species.
A new species of armored scale, Fiorinia yongxingensis (Hemiptera: Coccomorpha: Diaspididae) from Hainan Province, China
Authors: LIU DI , CAI BO , FENG JINIAN
Published: January 2020

The adult female, adult male and all immature stages (except the male prepupa and pupa) of a new species of Fiorinia (Hemiptera: Coccomorpha: Diaspididae), F. yongxingensis Liu, Cai & Feng sp. n., collected from Hainan Province, China, are described and illustrated. A key is provided to identify the Fiorinia species known to occur in Hainan Province, China. The new species may become a significant pest on coconut palms.
Redescription and DNA barcoding of diurnal moth Athroolopha latimargo
Rothschild, 1914 bona sp., stat. rev. from the southern Iberian Peninsula (Lepidoptera: Geometridae: Ennominae)
Authors: GUERRERO JUAN J. , CUENCA E. DAVID , BARROS DAVID , ORTIZ ANTONIO S.
Published: January 2020

The rare and diurnal geometrid moth Athroolopha latimargo Rothschild, 1914 bona sp., stat. rev. is re-discovered and redescribed from the furthest point of the south of the Iberian Peninsula, for the first time since its original description as a subspecies of Athroolopha chrysitaria (Hübner, 1813) from North Africa. The range of this taxon is questioned. A mitochondrial COI barcode sequence was generated for the specimens and compared with Iberian and Sicilian Athroolopha species.
Energy Efficient and Quality of Service Compromise Techniques for Wireless Body Area Networks
Authors: Rasool Shaik Mahammad , Mudasser Abdul Wasay , Abdul Gafoor Shad Aqueel Ahmed
Published: January 2020

In the present era the use of e-health plays a major role in the field of medical science. Today a significant attraction interest is towards Wireless Body area network (WBAN). The major challenges of Wireless Body area network (WBAN) technique are to maintain the quality service and
to track the network stability for a longer time, e.g., probability of delivery, and latency. The main important issue is to maintain the energy efficiency within the formed network. Here we propose a protocol for WBANs based on MAC using the multi-dimension (MD) graph optimization to compromise
the energy consumption and QoS in data transmission. In WBANs, low battery performing on-body or inculcate biomedical sensor nodes are applicable to observe and gathers the physiological signals like body temperature, blood pressure, ECG and EEG. The MAC protocol design utilizes an optimization
algorithm to optimize the scheduled traffic and channel of WBAN. The proposed protocol simulation results will be better than TDMA, CA-MAC and IEEE 802.15.6 MAC in terms of energy efficiency and QoS for large network conditions.
Trust Evaluation Factors in Cloud Computing with Open Stack
Authors: Arora Shakti , Dalal Surjeet
Published: January 2020

Cloud computing can be used with three deploying models SAAS, IAAS, and PAAS. IAAS is the most adopted model used for research and innovations. On daily basis Tera bytes of data are being uploaded on the cloud. The Public cloud, Private cloud and hybrid clouds services are used by the
people for hosting their applications and computations. One of the major obstacle used in selection of cloud service providers is the lack of trust on CSPs. CSPs are providing different levels of security according to the requirements of users. Proposed paper demonstrates the Trust evaluation,
Trust calculation models, based on different security parameters like Turnaround time, Integrity, and reliability of data on cloud. How to select a cloud provider’s service, based on the derived parameters determines the trust value of service provider. A new dynamic trust calculation
approach is proposed in this paper. Integrity, Turnaround time (TE) and reliability parameters are considered for trust evaluation. Comparative analysis of different cloud providers with real time calculations of different cloud machines are done and made a comparative analysis of the parameter,
approximately 63% efficiency level is achieved while compiling the trust factor with standard cloud nodes. Open stack cloud software is used to create a cloud environment of the local machine which helps in compilation of the data at real time. Fog computing is used to calculate the results.
System Design of Management of Energy Resources in the Field of Housing
Authors: Lysanov Denis Mihailovich , Eremina Irina Ilyinichna , Isavnin Alexey Gennadievich , Ishmuradova Izida Ildarovna
Published: January 2020

The main areas of work connected with improvement of the sphere of housing are development of the regulating,managing configurations of the equipment, change parameters of real-time operation, remote data collection from metering devices, adjustment of volumes of the provided utilities.
It will allow to improve monitoring of functioning of a data collection system about the received utilities and to increase efficiency of identification of power losses in system. Automatic data acquisition from the metering devices of water and the electric power transferred directly to financial
settlements center will allow to reduce influence on them of a human factor, to exclude errors at removal and information transfer.
Evaluation of Electromagnetic Exposure to Heavy Oil Stock
Authors: Kemalov Ruslan Alimovich , Turdaliev Jasurbek Xoshimjonugli , Kemalov Alim Fejzrahmanovich
Published: January 2020

One of the promising and environmentally acceptable ways to radically solve the problem of improving the quality of bitumen is the creation of an intensive physical and chemical technology for their production based on the use of residual oil fractions activated by an electromagnetic
field. The task of maximizing the involvement of heavy oil residues in refining is very urgent in the face of increasing competition in the oil products market, on one side, and viseversa the background of inceciment of demands on their quality in view of environmental protect, on the other
side. To assess the potential of high viscosity oils and natural bitumen and, as well as conventional oils, it is necessary to conduct thorough investigations to determine the curves of the true temperature curve (TTC), density, sulphur content, low temperature and viscosity features, fractional
and hydrocarbon compositions. It has been established that prolonged irradiation has a destructive effect on most known organic particles. So, there is a request to study the performance features of materials like plastics, coatings and bitumen in the area of electromagnetic radiation and
its capability to withstand exposure to radiation. The effect of electromagnetic radiation on organic parts has recently been investigated to evaluate the impact of electromagnetic waves on bituminous materials, specially for asphalts, and to utilize in practice the data gained. Bituminous
particels vary significantly in their composition that relates to the resource of raw particles and the method of obtaining the particles.
Spin Retry Count Relation with Other hdd Parameters
Authors: Nasyrov Iskandar Nailovich , Nasyrov Ildar Iskandarovich , Nasyrov Rustam Iskandarovich , Khairullin Bulat Askarovich
Published: January 2020

The change of the SMART parameter 10 Spin retry count values depending on the operating time is considered; this parameter characterizes the number of repeated attempts to spin the disks up to operating speed if the first attempt was unsuccessful. This parameter is critical in the sense
that if the value of the attribute increases, then the likelihood of malfunctions in the mechanical part of the hard disk drives is high. The scientific task of the study is to establish the relationship between this parameter in failed hard drives and the values of other reliability parameters
for information stores from various manufacturers. In the course of the study, the drives of the HGST, Hitachi, Samsung, ST, Toshiba, WDC trademarks operated in the Backblaze largest commercial data centre were analysed. As a result of the analysis, the relationship between the specified parameter
and such parameters as 3 Spin-up time (time of spinning the disk package from standstill to operating speed), 4 Start/stop count (counting the spindle start/stop cycles), 12 Power cycle count (number of full drive switching on/off cycles), 192 Power-off retract count (the number of shutdown
cycles, including emergency), 193 Load cycle count (the number of magnetic head block moves in the parking zone/in working position cycles). It is shown that the nature of the change in the values of the considered parameters depends on the manufacturer of the hard drives. It is proposed to
carry out an individual assessment of the information storage device rotation mechanism reliability using the parameters identified as a result of the study.
Co Evolution of Information Society and Online Community: Concepts and Communication Practices
Authors: Korotets Igor Dmitrievich , Podshibyakina Tat’yana Aleksandrovna
Published: January 2020

The impact of the Internet on the life of society is growing on a global scale, while it remains an uncontrolled area of interaction for various online communities, which requires further investigation. The purpose of the article is to conceptualize the notion of “co evolution
of information society and online community” based on the theories of information society and analysis of communication practices. The objectives are to establish the factors of successful development and assess the prospects of this type of co evolution. The research uses both theoretical
and practical approaches. A dialectical method was the main method of philosophical reflection. Community informatics is another scientific approach (M. Gurstein, D. Loader). To explain the phenomenon of integrity of technology and social networks in complex socio-technical systems, the actor-network
theory (ANT) of Bruno Latour was used. This article gives a definition of co evolution as joint commensurate development of non-identical information processes and online communities. In the course of co evolution, “junction points” and “bifurcation points” were revealed
and its social effects and prospects were assessed. The factors in successful development of the process of the information society and the online community co evolution were assessed: knowledge, technology, and information management. The conclusion about a common pace of the information
society and the online community development not having been set was substantiated. The growing influence of online communities on society and a simultaneous trend towards secrecy and transformation into a new kind of social groups is a megatrend in the information society development. The
results obtained are of practical importance in studying the problems of information management in the global network and regulating the activities of online communities.
Creating Happiness at Workplace: Work Team Contributions and Concerns
Authors: Kukunuru Saigeeta , Pillai Mahesh R. , Kassem Amer Al
Published: January 2020

Upon start of the century, a developing assemblage of research has foundationally inspected the factors incident for the happiness in the work environment. When all is said in done, the relative group of research conducted in the area has contributed some effective contributions to
advocate for factors for happiness at the work environment, which in turn has created a helpful effect for projects and the people. However some proof is blended. To help further studies in the area, the study address these points in two dimensions of happiness. The critical point is to audit
the available past research on happiness in the existing work place environment and to differentiate the critical points to give guidance for further studies. The subsequent studies is to provide a hypothetical structure which clarifies the manner people will decipher happiness in the work
environment. Later to address how it might be generally advantageous. Drawing on the thought that enjoyment in the working environment is subjective depending on each person’s preferences, our proposed system gives a more nuanced comprehension of the worldly procedures and logical variables
that clarify how people evaluate and eventually advantage from happiness.
Genomic Research in International, European, and Russian Jurisprudence
Authors: Ponomareva D. V. , Kosilkin S. V. , Nekoteneva M. V.
Published: January 2020

Modern science achievements contribute to the development of international and national ethical and legal approaches in the field of genome research while respecting human rights, ensuring safety, and maintaining the potential for scientific and technological progress. At the same time,
there are no legal documents devoted exclusively to biomedicine and genomic research. This situation has led to the development of international standards either through the general principles of protecting human rights or through “soft law” norms. In addition, a significant regulatory
gap exists caused by the lack of security measures in international jurisprudence. A similar trend occurs at the regional level. At the same time, in the framework of the Council of Europe, a single international treaty has been adopted that is directly devoted to bioethics and genomic research.
The Convention for the Protection of Human Rights and Dignity of the Human Being with regard to the Application of Biology and Medicine: Convention on Human Rights and Biomedicine was adopted by the Council of Europe in April 1997 in Oviedo. The active development of biomedicine and genomic
research caused conflicts between ethics and law. These issues became cases in highest judicial instances, including supranational structures, in particular, the Council of Europe and the European Court of Human Rights (ECHR). The ECHR influences Russia through the so-called “non-prohibitive
practice.” Nevertheless, despite the law’s imperfections, Russia develops its own approach to the existing system of international standards that admit national uniqueness in this sphere. Despite attempts to restrict the influence of supranational judicial institutions on the Russian
legal order in the middle of this decade, the practice of the ECHR as a source of Russian law influences the practice of Russian courts even in this sphere (Russian judges refer to the decisions of the ECHR).
Measurement of Readiness Levels for Adoption of Enterprise Resource Planning Clouds in Small Medium Enterprise with Net Ready Model
Authors: Terminanto Agung , Hidayanto Achmad Nizar , Nugroho Wahyu
Published: January 2020

Industry 4.0 has changed the way we live, work and interact, creating new opportunities and challenges. To deal with these challenges, SMEs need an application that can integrate and automate SME business processes. Small and Medium Enterprises are very important for Indonesia’s
economic growth. The 2016 economic census conducted by the Central Bureau of Statistics stated the rapid economic growth among MSMEs. The more rapid growth of the market, the greater the competition in the market coupled with the current digital era. The study was conducted to measure the
readiness of small and medium enterprises in the Bogor area that are engaged in fashion for Cloud ERP adoption. Readiness measurement is done by the Net Ready method which has four variables, namely: Leadership, Governance, Competencies, Technology. The Net Ready method further assesses the
readiness to the level of the organization and the results of measurements which each have different value contributions. Governance provides the biggest contribution in the assessment of Net Ready which has a score of 1.06. Competencies provide the second largest contribution which has a
score of 0.77. Technology provides the third largest contribution which has a value of 0.72. Leadership makes the smallest contribution in this study which has a score of 0.58, lack of management awareness of integrated information systems to make new business strategies. The total score obtained
from the summary of each variable total score produces a value of 3.12. The total score can be categorized as Bogor region SMEs engaged in fashion, quite ready to adopt Cloud ERP.