bluuebunny/crossref_metadata_2025 huggingface dataset:
Mechanism of Neural Stem Cell-Derived Exosomal miR-9a-5p Overexpression Improving Survival and Neurogenesis in Ischemic Stroke Rats
Authors: Liu Jiale , Lin Chaoqun , Gu Chenyang , Zhang Qiankun , Feng Tingle , Duan Wenjie , Huang Jiajun , Long Jun , Qiu Yunhui , Ahmed Waqas , Khan Ahsan Ali , Cai Hengsen , Hu Yong , Zhu Zhihan , Huang Shiying , Chen Lukui
Published: December 2023

As a momentous condition disease, ischemic stroke could lead to physical disability and death. Here, the protective effect of miRNA up-regulated in neural stem cells (NSCs) derived exosomes on ischemic stroke in rats and their molecular mechanisms were investigated to reveal the therapeutic
target of exosomes and suggests new approaches to treat ischemic stroke. miRNAs differentially expressed in exosomes derived from NSCs at various differentiation stages were detected by high-throughput sequencing for miRNAs. The impacts of miR-9a-5p upregulation were assessed on the differentiation
of NSCs. The effects of exosomes derived from normal NSCs and NSCs with up-regulated miR-9a-5p on cell survival and differentiation and AMPK activation were investigated in vitro and in vivo. The high-throughput sequencing analysis revealed that miR-9a-5p was differentially expressed
in NSC-derived exosomes at various stages of differentiation. MiR-9a-5p upregulation in exosomes promoted cell differentiation of NSCs. Furthermore, it can sensitized the AMPK signaling pathway. Following deprivation/reperfusion of oxygen-glucose, the differentiation of NSCs was restored,
and exosomes significantly reduced cell apoptosis. MiR-9a-5p exosomes reduced the blood-brain barrier permeability and the infarct volume of rats with ischemic stroke in vivo. Neural cell apoptosis was reduced, thus indicating that miR-9a-5p could inhibit the cell apoptosis in vivo.
AMPK activation was induced and increased in the MACO/R rat with miR-9a-5p exosomes. MiR-9a-5p exosomes could promote AMPK phosphorylation, increase NSC survival and enhance cell differentiation; this could inhibit the progression of ischemic stroke by maintaining an adequate number of neural
cells and promoting endogenous NSC differentiation.
Resilience, immunity, L2-teacher grit, and reflective teaching in language instruction: in service classes matters
Authors: Ismail Sayed M. , Nikpoo Iman
Published: December 2023

A professional training or staff development endeavor is known as an in-service program. During these programs, professionals get training and have the opportunity to discuss their work with others who are in their peer group. In the context of the field of education, the term "in-service classes" refers to the process by which instructors participate in additional education or training over the duration of their job in order to maintain or improve their level of professional knowledge, abilities, and practices. In spite of the fact that publicizing in-service programs for language teachers is of utmost significance, not enough focus has been placed on elaborating how they contribute to teacher-related traits. In this study, an effort was made to compare and contrast the outcomes and progress of language instructors who attended or did not attend an in-service program, as well as the effects of this decision on the teachers' resilience, immunity, L2-teacher grit, and reflective teaching. This research was of a quasi-experimental type, and it included participation from 103 English as a Foreign Language (EFL) teachers. During this research project, members of the first group, known as the control group, were not required to attend any in-service courses, whereas members of the second group, known as the experimental group, were. According to the findings of the MANOVA, EFL teachers who participated in in-service training courses had a significantly better level of resilience, immunity, L2-teacher grit, and reflectivity. It is hoped that the outcomes of this study will shed light on the significant contributions offered by in-service training programs and open up new avenues for the mental well-being of EFL teachers.
Experience Related to Acceptance of Illness among People with Early-Stage Dementia: A Phenomenological Study
Authors: Park Jaewon
Published: December 2023

Purpose: This study aims to describe the structure of the experience related to acceptance of illness among people with early-stage dementia (PWED).Methods: Participants were six people who had Alzheimer’s disease or vascular dementia. Their clinical dementia rating scores were 0.5 or 1. Data were collected from individual in-depth interviews. The collected qualitative data were analyzed based on Giorgi’s descriptive phenomenological method.Results: The five constituents and eight sub-constituents were derived from the experience related to acceptance of illness among PWED; ‘Facing the changed me’, ‘Facing changes in roles and relationships with others’, ‘Conflict between recognizing and denying dementia in daily life’, ‘Perceiving the limits and accepting dementia’, and ‘Reconstructing daily life for the prolongation of the current health status’.Conclusion: This study contributes to the expansion of the in-depth understanding of the experience related to acceptance of illness among PWED. The results of the study will be helpful as basic data for community health nurses to develop interventions to improve acceptance of illness of PWED.
Development and Effectiveness of a Basic Epidemiological Investigation Simulation Program of Emerging Respiratory Infectious Diseases for Nursing Students: Application of Standardized Patients
Authors: Park Jiyun , Yeom Gye Jeong
Published: December 2023

Purpose: This study aimed to develop a simulation-based education program of emerging respiratory infectious diseases using standardized patients for nursing students, and to test the effects on basic epidemiological investigation performed while wearing Level D Personal Protective Equipment (PPE).Methods: A total of 64 senior nursing students were recruited and assigned to either the experimental group (n=33) or a control group (n=31) in May 2022. This program was developed based on the analysis, design, development, implementation, and evaluation model. The analysis phase consisted of a literature review and target group survey. In addition, learning objectives and a structure were designed, and a scenario was developed with expert consulting. In the implementation phase, the program was conducted the course of 3 hours. The evaluation phase involved verification of the effects on clinical performance, self-efficacy, and anxiety related to basic epidemiological investigation, as well as an assessment of satisfaction with the program.Results: There were significant differences between the experimental and control groups in clinical performance (Z=-2.15, p=.010) and anxiety related to basic epidemiological investigation (Z=-4.02, p<.001). However, there was no significant difference in self-efficacy related to basic epidemiological investigation.Conclusion: The results indicate that this simulation-based education program was effective in improving clinical performance and reducing anxiety related to basic epidemiological investigation of nursing students. In addition, this program is expected to be widely used as an epidemiological investigation education for the initial prevention of infectious diseases.
Identifying Popular Products at an Early Stage of Sales Season for Apparel Industry
Authors: Wang Jiayun , Wu Shanshan , Jin Qingwei , Wang Yijun , Chen Can
Published: December 2023

The early phase of launching a new apparel product is critical for gaining insights of its performance and classifying it into different categories such as fast selling, average selling, and slow selling. We propose a new ranking-based method to identify the product popularity that predicts regional and national rankings of products based on sales data at an early stage of a sales season. Our method enables companies to efficiently identify popular products within a remarkably short span of two to four weeks.
Influence of Cyberbullying Victimization on Suicidal Ideation in Adolescents: Focusing on the Moderating Effects of Parenting Attitude
Authors: Park Sung Won , Yun Hyun Jung
Published: December 2023

Purpose: This study aimed to examine the effect of cyberbullying victimization on suicidal ideation and test the moderating effect of parenting attitudes in the relationship between the two variables.Methods: This study analyzed the data of 5651 middle and high school students from the “Children and Youth Human Rights Survey” conducted by the National Youth Policy Institute in 2020. For analysis, t-tests, ANOVA, Pearson's correlation, multiple regression, and a simple model of PROCESS macro analysis methods were performed.Results: The factors influencing suicidal ideation were cyberbullying victimization (β=.10, p<.001), decision-respecting parenting attitude (β=-.16, p<.001), and neglectful parenting attitude (β=.12, p<.001). These factors explained 16.0% of the variance in suicidal ideation after adjusting for other covariates(F=64.55, p<.001). Additionally, among parenting attitudes, only a neglectful parenting attitude (B=-0.01, p<.001, R2=.14) moderated the relationship between cyberbullying victimization and suicidal ideation among adolescents.Conclusion: Based on the findings, this study discussed practical and policy implications for promoting supportive parenting attitudes in preventing cyberbullying victimization and suicidal ideation.
Logistics Management of Energy Flows: Theoretical and Methodological Principles
Authors:   Poltava University of Economics and Trade, Perebyynis V. , Rogoza М. ,   Poltava University of Economics and Trade, Mykolenko I. ,   Poltava State Agrarian University, Kononenko Z. ,   Poltava University of Economics and Trade
Published: December 2023

The article describes theoretical and methodological principles of logistic management of energy flows. It is appropriate to consider the energy flow as a set of energy resources circulating in the logistics system, as well as between the logistics system and its external environment in order to provide energy for logistics processes. A part of the energy flow is a component of the material flow. This applies, in particular, to energy resources that have a liquid, solid and gaseous material substance. Dimensionality of the energy flow can be expressed as the ratio of the amount of energy (in conventional units of fuel) to the unit of measurement of time (hour, day, month, quarter, year). The energy flow turns into a stock of energy resources if it is considered during the implementation of logistics operations at a certain point in time (except for electricity, which is quite difficult to accumulate in many types of economic activity). It has been established that the energy flow goes through the following stages: procurement stage, storage stage and use (transformation) stage. Approaches to calculating the amount of energy flow at the specified stages and the total amount of energy flow have been reasoned. The logistics management of energy flows should be understood as the process of strategizing, planning and controlling the flow of energy resources from the supplier to the business entity (as a logistics system), as well as in the intra-production logistics subsystem during energy use. The matrix of the logistic management system of energy flows in the process of energy supply (energy generation) and energy consumption has been developed. It is appropriate to consider the task of optimizing energy flows as minimization of the total logistics costs of business entities and territorial communities in the process of energy supply and energy use.
Institutional Provision of Formation and Development Spatial Business Systems
Authors:   Institute of Industrial Economics of the NAS of Ukraine, Liashenko V. , Lischuk O. ,   Institute of Industrial Economics of the NAS of Ukraine
Published: December 2023

The paper analyzes the institutional support for the formation and development of clusters within the framework of the approach that studies aspects of cluster policy and is part of the scientific direction of research into the development processes of organized clusters. It was determined that the purpose of applying the cluster policy is to unite enterprises of a similar field of activity into groups to increase the efficiency of production, creation and use of innovations, and economic development of the region. It has been established that the development of cluster policy at the level of clusters (rather than industries) avoids many distortions associated with suppliers in the value chain and better focuses on specific problems faced by companies in a number of related industries.
The Organizational and Economic Mechanism of Ensuring the Effective Functioning and Development of Enterprises of the Agro-Industrial Complex of Ukraine
Authors:   University of Customs and Finance, Bezuhlyi O. , Koliesnik V. ,   Dnipro State Agrarian and Economic University, Sokolenko A. ,   PSTU "Pryazovskyi State Technical University"
Published: December 2023

In the article, due attention is paid to solving a set of tasks, the main of which are: revealing the essence of the organizational and economic mechanism of ensuring the profitability of agricultural enterprises and its connection with the economic mechanism of their functioning; elucidation of the main theoretical provisions regarding the formation of an organizational and economic mechanism for ensuring the profitability of agricultural enterprises; supplementing the methodological toolkit for analyzing the indicators of the formation and effective functioning of the organizational and economic mechanism of ensuring the profitability of agricultural enterprises in modern business conditions; development of the principles of justification of pricing – the main factor in the formation of the efficiency of agricultural production; improvement of the constituent elements of the system of financial and credit provision of the profitability of agricultural enterprises; forecasting the level of profitability of production of the main types of products in agricultural enterprises, etc. The work carried out a comprehensive study of theoretical foundations, development of practical recommendations and proposals for the formation of an organizational and economic mechanism for ensuring the profitability of agricultural enterprises in the context of increasing the efficiency of the functioning of the agrarian sphere, namely: a comprehensive approach to the formation of the components of an organizational and economic mechanism for ensuring the profitability of enterprises is substantiated; the method of studying profitability and classifying its manifestations in agriculture has been improved; a compensatory mechanism for reducing the price of loans for agricultural enterprises was proposed by introducing a preferential rate that takes into account the type of loan, its intended use and the profitability of the lending facility; a toolkit for forming the price component of enterprise profitability is recommended; the methodology for the comprehensive assessment of the economic and economic parameters of the formation of the profitability of enterprises is substantiated; a systematic approach was carried out to identify the main factors of the macroeconomic, regional and industry environment, the comprehensive consideration of which will contribute to the formation of a synergistic effect; an algorithm for prognostic assessment of the formation of the profitability of the production of types of agricultural products was developed.
Institutional Approach to the Formation of Strategic Directions of Sales Activities of Market Entities
Authors:   SHEI Donbass State Engineering Academy, Bolotina Ye. , Shubna O. ,   SHEI Donbass State Engineering Academy, Shirkova A. ,   SHEI Donbass State Engineering Academy, Bondarev Ya. ,   SHEI Donbass State Engineering Academy
Published: December 2023

The article deals with issues related to the management of sales activities of domestic enterprises. Measures have been taken to improve the strategic management of the company's sales activities on the foreign market. . The main purpose with which enterprises enter foreign markets is to maximize profits by using economies of scale and the ability to conduct research on target foreign markets. Strategies for entering the foreign market have been defined, based on cost accounting and attractiveness for investment. It has been proven that two main technologies are used to promote goods through distribution channels: PUSH ("push" means "push") and PULL ("pull" means "pull"). When using the PULL technology, the main task of the product seller is to ensure the loyalty of the consumer to his company. Exclusive products and integrated services are best suited for this type of demand stimulation. To improve the process of strategic management of means of sales promotion, an algorithm was formed, which contains ten main stages (stages).
Financial and Economic Tools for Ensuring the Effectiveness of Implementation of Corporate Integration and Control in Joint-Stock Companies
Authors:   Central Ukrainian National Technical University, Havrylova N. , Boiko O. ,   Private Institution of Higher Education "Rauf Ablyazov East European University", Remzina N. ,   Odessa National Maritime University, Sukhachova O. ,   Central Ukrainian Institute of Human Development
Published: December 2023

The purpose of this study was to systematize the tools and generalize the features of the corporate control implementation in a joint-stock company. The scientific and methodical approach to developing the instrumental support for corporate control implementation by the different groups of corporate relations participants has been substantiated. The composition of main characteristics and requirements for using the various instruments of corporate control implementation has been established. These requirements determine the effectiveness of corporate control instrument using bycorporate relations participants. The features of corporate control instruments usage has been reviewed in terms of such types of control as insider, outsider and mixed. The necessity of corporate control instruments developing through orientation on the institutionalization corporate cooperation forms and considering the conditions of national economy market transformation has been proven. The original approach to determining the motivational complexes of groups of corporate relations participants is proposed. This approach has taken into account the nature of corporate control claims. Such a proposal will prevent the aggravation of socio-economic contradictions and corporate conflicts which may be an obstacle to the sustainable development of a jointstock company.
Economic Riskology of Corporate Integration Processes in the Management of Joint-Stock Companies
Authors:   Central Ukrainian Institute of Human Development, Didovets I. , Karpunina M. ,   Classic Private University
Published: December 2023

It was unsubstantiated nature of mergers and acquisitions of joint stock companies as the processes of redistribution of equity control. Author generalized nature for obtaining corporate control over the joint-stock companies in the course of operations of a hostile M & A. and considered it mechanisms. Then it was proposed classification of the main types of mergers and acquisitions of enterprises. Also it was generalized approach to formation of a monitoring system of benchmarks that identify possibility of attempts at hostile mergers and acquisitions over the strong and weak signals. It was summarized systems of measures that can be used to counteract this process reviewed. possible variants infringement of the rights and interests of shareholders through unpredictable changes in the size or structure of the share capital in the implementation of the operations of a hostile M & A. Author substantiated composition of factors in the formation of the company attractive for attempts a hostile mergers and acquisitions. Finally it was defined criteria for evaluation of optimal ways to protect the Company against attempts of hostile mergers and acquisitions.
Robótica educativa para el desarrollo de la competencia STEM en maestras en formación
Authors: Romero-Rodríguez José-María , De la Cruz-Campos Juan Carlos , Ramos Navas-Parejo Magdalena , Martínez-Domingo José Antonio
Published: December 2023

INTRODUCCIÓN. El porcentaje de mujeres que cursan titulaciones STEM (Science, Technology, Engineering and Mathematics) es inferior al de hombres, debido a condicionamientos sociales, estructuras institucionales, asesoramiento deficiente y entornos de aula de educación temprana hacia otras áreas. En concreto, algunos estudios empiezan a evidenciar la brecha de género que se produce en este ámbito primordial para el desarrollo de la sociedad. En esta línea, la robótica educativa se ha convertido en una herramienta efectiva para contribuir a despertar vocaciones en el ámbito STEM. MÉTODO. El objetivo de este trabajo fue desarrollar la actitud y competencia STEM a través de la robótica en las maestras en formación del Grado en Educación Primaria, para ello se aplicó un diseño cuasiexperimental con pretest-postest, donde participaron un total de 104 estudiantes. RESULTADOS. El grupo experimental que trabajó de forma práctica con robótica educativa durante 13 semanas obtuvo una mayor puntuación postest que indicó un aumento de la actitud y competencia STEM en comparación con el grupo control. No obstante, no se encontraron diferencias significativas intragrupo ni intergrupo. DISCUSIÓN. Aprender de forma práctica materias STEM motiva hacia la predisposición de profundizar en programación, mejora las actitudes y competencias STEM a través de la robótica educativa en las aulas, favorece la inclusión de las estudiantes en dichas materias y reduce la brecha de género existente. Finalmente, fomentar la motivación y vocación en materias STEM puede incidir en el hecho de que las maestras en formación incorporen en su posterior ejercicio de la docencia elementos STEM como la robótica, pudiendo desarrollar experiencias positivas y motivadoras en las aulas de educación primaria, para que el alumnado pueda disfrutar aprendiendo robótica y propiciando que se despierte la curiosidad por el aprendizaje de estas materias.
SOCIAL CONTRADICTIONS OF SMALL TERRITORIES OF THE VOLOGDA OBLAST: ASSESSMENT METHODOLOGY
Authors: Smoleva Elena O.
Published: December 2023

The relevance of the study is due to the growth of the urban population, for whom the quality of the place of residence is of paramount importance. The quality and comfort of the environment determine the competitiveness of municipalities, their sustainable development. However, small territories of Russia are characterized by the presence of pronounced social contradictions, negative processes that hinder their development. The purpose of the research stage is to create an express methodology for assessing the state of affairs in small territories in order to develop the right management strategies. The methodological component of the work is devoted to the assessment of the situation of small territories and their typologies, data on domestic assessment systems are provided. The information base of the study: official data of Rosstat, a database of indicators of municipalities, objective indicators of the Urban Environment Quality Index for 2018-2022, data on the development of small and medium-sized businesses for 2021, a sociological survey of the population of the Vologda Oblast (N = 1500; sampling error does not exceed 5%). 10 small towns of the region were selected to form the rapid assessment methodology. The Vologda Oblast municipalities with favorable and unfavorable urban environment have been identified, problem areas, including those related to demographic processes, have been identified. Objective characteristics of small towns in the region are supplemented by the opinion of citizens on the activities for their improvement and development of the urban environment. It is concluded that the indicators of the express methodology should be supplemented with studies of territories, taking into account the development of the institutional environment and the activity of local communities, the possibilities of collaboration of various actors in solving the social contradictions of small towns.
DEVELOPMENT OF A COMFORTABLE URBAN ENVIRONMENT IN LARGE CITIES IN INDEX ASSESSMENT
Authors: Zhdanova Angelina E.
Published: December 2023

In modern conditions, for large cities, the problem of creating a comfortable urban environment is urgent, which implies the creation of conditions to provide a favorable, safe and accessible environment for the population to live. A solution to this problem is in demand for large cities that have high resource potential, attracting labor resources and investments to stimulate development. The purpose of this study is to study trends in the formation of a comfortable urban environment in large cities, as well as to consider the best practices for the improvement of these cities. The main information base for the study was the urban environment quality index, formed by the Ministry of Construction and Housing and Communal Services of the Russian Federation within the framework of the federal project “Formation of a comfortable urban environment.” The theoretical review examines the basic concepts and identifies key aspects of the development of a comfortable urban environment in the scientific discourse and practice of urban planning. The dynamics of index indicators in federal districts from 2018 to 2022, as well as changes depending on assessments of urban space in various directions, are considered. According to the results of the study, it was revealed that out of 64 large cities, 60 are classified as cities with a favorable urban environment. A trend has been established for the disproportionate development of the urban space of large cities in the country relative to the federal districts, northern and southern, European and Asian parts. The highest urban environment quality index was found in cities located in the Central and Southern Federal Districts, in close proximity to the capital. The final part of the study examines the practices of improving a comfortable urban environment that participate in the federal project and are included in the register of the best according to data for 2022. The importance and necessity of participatory participation (i.e. complicity) of residents in the implementation of practices for the improvement and development of urban space is noted.
The Subcutaneous Variant Dermatofibrosarcoma Protuberans of the Breast With Nipple Areolar Complex Invasion Treated With Central Lumpectomy: A Case Report
Authors: Na Yong Min , Kwon Yong Bin , An Sang Yun , Ma Hye Un , Park Sang Chun , Jung Seo Won , Lim Soo Young , Ryu Young Jae , Lee Hyo Jae , Lim Hyo Soon , Lee Ji Shin , Cho Jin Seong , Park Min Ho
Published: December 2023

Dermatofibrosarcoma protuberans (DFSP) is a rare low-grade soft tissue sarcoma and the breast is less commonly affected than the torso. DFSP can be misdiagnosed as neurofibroma, desmoid tumor, malignant melanoma, or Kaposi sarcoma. A variant of DFSP originates from the subcutaneous layer and is called subcutaneous variant dermatofibrosarcoma protuberans (SC-DFSP). It can be easily confused with breast phyllodes tumor, myofibroblastoma, myoepithelioma, or advanced breast cancer, such as fibromatosis-like metastatic carcinoma. Following punch biopsy, the treatment of choice for breast DFSP is complete excision with negative margins ≥ 2 cm. We present a case of breast SC-DFSP with nipple areolar complex invasion.
Molecular Docking and Molecular Dynamic Simulation on the Interaction of Saffron’s Active Compunds with HER-2 Protein
Authors: Adelina Rosa , Maharani Dila Aulia , Octaviani Putri , Putra Sendi Handika
Published: December 2023

Human epidermal growth factor receptor-2 (HER-2) is an essential oncogene in breast cancer. HER-2 causes 25% of breast cancer, and this type of cancer tends to grow and spread faster than others but had a good response to HER-2 targeted therapy. This study aims to analyze chemical compounds in saffron plants (Crocus sativus) that potential to breast anticancer activity by inhibiting HER-2 receptor (PDB ID: 3RCD). The study employed in silico research such as molecular docking using AutoDock Tools software, and visualization with Biovia Discovery Studio. In addition, molecular dynamic simulation was conducted using GROMACS software, with visualization performed using Grace. The molecular docking results showed that Crocetin has a lower binding energy value of -8.37 kcal/mol compared to Herceptin, which is -7.11 kcal/mol and the lowest energy among Saffron bioactive compounds. These results indicated that the affinity of Crocetin in binding to HER-2 receptor is better than Herceptin. The molecular interactions were hydrogen, hydrophobic, electrostatic, and unfavorable bonds. The MD results showed that the RMSD value meets the 0.2-0.5 nm stability requirements. According to the data analysis, Herceptin appears to have a more stable RMSF value when compares to Crocetin. The Rg graph of both complexes showed stability until the end of the simulation. The H-bond results show that the Herceptin complex has more hydrogen bonds than the Crocetin complex. These results showed that the chemical components of saffron plants have the potential as breast anticancers by inhibiting the HER-2 receptor.Keywords: anticancer, Crocus sativus, HER-2 receptor, molecular docking, molecular dynamic.
Ethanol Extract of Artocarpus odoratissimus (Tarap) Bark Inhibit Migration of MDA-MB-231 Triple Negative Breast Cancer Cells
Authors: Rachmi Eva , Hasanah Nurul , Irawiraman Hadi , Nuratifah Annisa Puteri , Nahusuly Fritz
Published: December 2023

Breast cancer is the most diagnosed cancer in the world, with triple negative breast cancer (TNBC) being one of its subtypes that exhibits an aggressive clinical course, a tendency for early metastasis, and a poor prognosis. Tarap (Artocarpus odoratissimus Blanco) is an endemic plant of East Kalimantan, which possesses anticancer potential. This study aimed to explore the ability of ethanol extract of Tarap bark (EETB) in reducing cell viability, inducing apoptosis and inhibiting migration of MDA-MB-231 cells. Cell viability was observed by 3-(4.5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. EETB -induced apoptosis was analyzed by double staining allophycocyanin (APC) Annexin V with PI kit through flow cytometry. Cell migration was determined through scratch assay. EETB was found to decrease cell viability with an IC50 value of 1607.302 μg/ml (R=0.369). EETB’s ability to induce total apoptosis did not show significant differences across various concentrations. EETB was able to inhibit cell migration, especially at concentrations of 800 mg/ml, both at 24-h and 48-h observations. This finding demonstrates that EETB has a weak effect on reducing the viability and inducing the apoptosis of MDA-MB-231 cells. EETB induced morphological cells type change in to globular type and significantly inhibits two-dimensional migration of MDA-MB-231 cells.Keywords: Tarap, Artocarpus odoratissimus, triple negative breast cancer.
Etlingera elatior Compounds as Anticancer Agents of Breast Cancer Through Inhibition of Progesterone Receptor: An In Silico Study
Authors: Afladhanti Putri Mahirah , Hamzah Haidar Ali , Romadhan Muhammad Despriansyah , Putri Safa Nabila , Angelica Ellen Callista , Theodorus Theodorus
Published: December 2023

Breast cancer is the leading cause of cancer-related death in women globally. Progesterone receptor (PR) is known as the prime example of receptors amenable to targeted breast cancer drug therapy. Etlingera elatior is an herbal plant that has been renowned to have anticancer effect. This study aimed to identify the potential compounds derived from Etlingera elatior as anticancer agents of PR in breast cancer using molecular docking method. This study used fifteen compounds from Etlingera elatior along with lonaprisan as the comparative drug. The PR was downloaded from RCSB, whereas compounds and lonaprisan were from Pubchem. The drug-likeness test based on Lipinski’s rule of five was conducted using SwissADME. Toxicity analysis using admetSAR 2.0 was used to predict toxicological profile of the compounds. Compounds and lonaprisan were docked on PR using AutoDock tools 1.5.6 and AutoDock Vina 1.1.2. Molecular interactions were visualized by Discovery Studio v16. A total of nine compounds met the criteria as drugs based on drug-likeness and toxicity tests. All nine compounds except caffeic acid and vanillic acid had higher binding affinities on PR compared with lonaprisan. Ergosterol peroxide exhibited the highest binding affinity on PR with values of -9.8 kcal/mol. Moreover, ergosterol peroxide-PR interaction had thirteen hydrophobic bonds and a hydrogen bond with amino acid residues were found in the active site of PR. Most of the compounds found in Etlingera elatior have the potential to be anticancer agents of PR in breast cancer with ergosterol peroxide being the most potential compound. Further in vitro and in vivo research are needed.Keywords: breast cancer, ergosterol peroxide, Etlingera elatior, progesterone receptor, in silico.
Photovoice: Participatory research methods for sustainability ‐ toolkit #8
Authors: Huber Jule Marie , Bieling Claudia , García-Martín María , Plieninger Tobias , Torralba Mario
Published: December 2023

Photovoice is a participatory research method based on participant-led photography and dialogue. It is particularly suited to engaging vulnerable groups to visually document a specific issue that affects their personal lives. Because photovoice is based on images and language alike,
it encourages participants to reflect on the issue and elevates marginalized voices by facilitating the expression of local knowledge, opinions, and experiences and allowing participants to identify their concerns and priorities.
Stellungnahme des Netzwerks Reallabore der Nachhaltigkeit zur Reallabore-Gesetz-Initiative
Authors: Parodi Oliver , Schwichtenberg Roy , Stelzer Franziska , Rhodius Regina , Schreider Claudia , von Wirth Timo , Lang Daniel J. , Marg Oskar , Wagner Felix , Egermann Markus , Bauknecht Dierk , Wanner Matthias
Published: December 2023

Das Bundesministerium für Wissenschaft und Klimaschutz (BMWK) möchte innovationsfreundliche Rahmenbedingungen für Reallabore schaffen. Im Sommer 2023 hat es dazu ein Grünbuch Reallabore veröffentlicht und einen Konsultationsprozess für ein Reallabore-Gesetz
eingeleitet. Das Netzwerk Reallabore der Nachhaltigkeit begrüßt die Initiative, sieht aber zugleich erheblichen Gestaltungsbedarf. Die NaWis-Mitglieder unterstützen die hier vorgestellte Position des Netzwerks.
FACEBOOK KISKANÇLIĞI VE BAĞLANMA: KISKANÇLIĞIN VE YALNIZLIĞIN ARACI ROLÜ
Authors: ÖZGÜLÜK ÜÇOK S. Burcu , YILMAZTÜRK Nergis Hazal , ATAY Bünyamin
Published: December 2023

Facebook kullanımının, romantik ilişkilerin kurulmasına fırsat sağlamakla beraber, partnerlerin birbirlerini kontrol etmesine ve Facebook kıskançlığına yol açabildiği görülmektedir. Literatürde çok boyutlu kıskançlık, bağlanma, yalnızlık gibi ilgili değişkenlerin Facebook kıskançlığı ile ilişkisinin incelendiği çalışmalar sınırlıdır. Bu bağlamda bu çalışma, kıskançlığın ve yalnızlığın, bağlanma ile Facebook kıskançlığı arasındaki ilişkide aracı rolünün incelenmesini amaçlamaktadır. Veriler 18-65 yaş arasında, romantik ilişkisi olan ve hem kendisi hem de partneri Facebook kullanıcısı olan 220 katılımcıdan toplanmıştır. Yol analizi sonuçları, kıskançlığın Facebook kıskançlığını yüksek düzeyde yordadığını, kaygılı ve kaçınan bağlanmanın ise orta düzeyde yordadığını ortaya koyarken, yalnızlığın ise Facebook kıskançlığını istatistiksel olarak anlamlı düzeyde yordamadığını göstermiştir. Ayrıca, kaçınan bağlanmayla Facebook kıskançlığı arasındaki ilişkide kıskançlığın aracı rolü anlamlı bulunurken, yalnızlığın anlamlı bir aracı rolünün olmadığı bulunmuştur. Kaygılı bağlanma ile Facebook kıskançlığı arasındaki ilişkide ise yalnızlığın ya da kıskançlığın istatistiksel olarak anlamlı herhangi bir aracı rolünün olmadığı bulunmuştur. Bulgular ilgili literatür ışığında tartışılarak ileriki araştırmalarda farklı ilişki durumlarını (sözlü, nişanlı, evli çiftler vb.) kapsayan örneklemler dikkate alınarak ve bağlanma türleri, Facebook kıskançlığı, diğer sosyal medya araçlarının kullanımıyla doğan kıskançlık türlerini de entegre ederek, gruplar arası ve gruplar içi çalışmalar yapılması önerilmiştir.
Issues of Women with Epilepsy and Suitable Antiseizure Drugs
Authors: Lee Sang Kun
Published: December 2023

Seizure aggravation in women with epilepsy (WWE) tends to occur at two specific times during the menstrual cycle: the perimenstrual phase and the ovulation period. Antiseizure drugs (ASDs), especially those that induce enzymes, can accelerate the metabolism of hormones in oral contraceptives, rendering them less effective. Estrogen in contraceptive pills increases the metabolism of lamotrigine. Physiological changes during pregnancy can significantly impact the pharmacokinetics of ASDs, potentially necessitating adjustments in dosage for women with epilepsy to maintain seizure control. The use of valproate in pregnant women is associated with the highest risk of major congenital malformations among ASDs. Risks of major congenital malformations associated with lamotrigine, levetiracetam, and oxcarbazepine were within the range reported in the general population. Exposure to valproate can lead to lower IQ in offspring. Reduced folic acid levels are linked to orofacial clefts, cardiovascular malformations, and urogenital and limb anomalies in WWE. Decreased folate levels are expected with the use of enzyme-inducing ASDs. However, a high dose of folate was associated with an increased risk of cancer in children of mothers with epilepsy. Most ASDs are generally considered safe for breastfeeding and should be encouraged. However, no single ASD is considered ideal for childbearing WWE. Lamotrigine and levetiracetam are relatively more suitable options for this situation.
Advances in ferroptosis of cancer therapy
Authors: Dong Ying , Xu Chaojie , Guo Jinli , Liu Yuchen
Published: December 2023

Ferroptosis is an iron-dependent mode of programmed cell death characterized by Reactive Oxygen Species (ROS) accumulation lipid peroxidation and glutathione depletion. It is a novel form of cell death different from apoptosis and necrosis. Because of its unique mode of cell death, it has attracted a large number of research reports from the oncology community. Changes in iron ions and accumulation of lipid peroxides have confirmed the correlation between ferroptosis and tumors, and thus ferroptosis can be considered to have a great oncological therapeutic potential. This paper brings to light the significance of metabolic pathways and key genes like System Xc-/Glutathione Peroxidase 4 (GPX4), Membrane-bound O-acyltransferases 1 (MBOAT1) and Membrane-bound O-acyltransferases 2 (MBOAT2) in modulating ferroptosis in cancer cells. The susceptibility of cancer cells to ferroptosis, influenced by their high levels of reactive oxygen species and specific mutation profiles, is analyzed, suggesting new avenues for enhancing the effectiveness of established cancer treatments. In this review, we address the current understanding of ferroptosis induction and ferroptosis defense mechanisms, briefly describe the role and mechanisms of ferroptosis in tumor suppression, and discuss therapeutic strategies for targeting ferroptosis caused by tumors.
Spór o przynależność państwową Małopolski Wschodniej (1919–1923)
Authors: Franz Maciej
Published: December 2023

After the end of World War I, the struggle for post-war order in Europe began. The collapse of the superpowers: Germany, Austro-Hungary and Tsarist Russia, allowed the creation of many countries in Central Europe. Every nation wanted to have its own state. This led to the emergence of political and military conflicts over disputed territories. One of such territories was Eastern Lesser Poland, which, after fighting with the Bolsheviks and Ukrainians, was occupied by the nascent Poland. The Ukrainians put forward their claims to this territory and their own state. Own interests, including the protection of the occupied Transcarpathian Ruthenia, were pursued by the newly established Czechoslovakia. The Western powers in the League of Nations supported various solutions. The dispute lasted until the beginning of 1923 and was one of the last chords in the construction of the Versailles order in Europe.
O bezpieczeństwo i porządek publiczny. Organizacja struktur terenowych Policji Państwowej w Małopolsce Wschodniej w pierwszych latach niepodległości (1919–1924)
Authors: Ostanek Adam Adrian
Published: December 2023

Regaining independence by Poland was only the beginning of the reconstruction of the state. One of the pressing problems was to create its foundations, including services responsible for public security. For this purpose, in 1919, the State Police was established. Creating its structures was much more difficult than issuing applicable legal acts. The ongoing armed conflicts, the unsolved issue of the borders of the Republic of Poland and other minor factors meant that they were built for several years. This article presents the background of the creation of the structures of the State Police in Eastern Lesser Poland in the years 1919–1924, that is from the issue of the Police Act, to the establishment of structures that survived until the outbreak of World War II. The source basis for the study are legal acts as well as archival materials and scientific studies relating to both general issues and the process of creation itself.
Stanisławów między wojnami. Ludność, architektura, gospodarka miejska
Authors: Krasnodębski Jarosław
Published: December 2023

In this article, I present Stanisławów in the interwar period in selected aspects. I would like to present various issues related to population changes, the development of architecture and the urban economy of Stanisławów. The timeline of the article covers the years 1919–1939, from the takeover of power in the city by the Poles (May 25), until the outbreak of World War II and the entry of the Soviets into the city (September 19). The analysis of the collected materials shows how diverse and rich that time was for Stanisławów and its inhabitants.
Krótki opis parafii diecezji latyczowskiej przyłączonych do archidiecezji mohylewskiej, sporządzony w 1799 r. Edycja źródła
Authors: Szczepaniak Jan
Published: December 2023

Formally erected around 1405, the Latin Catholic diocese of Kiev existed until the end of the 18th century (for church authorities until 1798, although Catherine II abolished it on 27 September 1795). The history of the diocese was extremely turbulent. Constant Tartar invasions, the Chmielnicki uprising, the Polish-Russian wars and the 17th and 18th century Cossack rebellions not only did not favour the development of the diocese and led to a reduction in its area, but on several occasions led to the destruction of its administrative structure. Renewed after the Cossack and Russian wars, the diocese had 10–11 churches by the end of the 17th century. After the further ravages that affected its territory in the late 17th and early 18th centuries, there were at least 25 churches before 1748. Cossack rebellions halted its development for some time. Nevertheless, by the end of the 18th century, there were 53 churches on the territory of the diocese, of which at least 42 had the status of parish churches. Despite the medieval origins of the diocese and its apparent development in the 18th century, there are not many entries in the bibliography on it. The same is true of the historiography of the Braclaw region (Lithuanian Podolia), which belonged to the Luck and Brest dioceses in the pre-partition period. The unsatisfactory state of conducted research is related to the small known source base. Recent queries have revealed several new sources for the history of the Latin Church in the south-eastern periphery of the Polish-Lithuanian Commonwealth, in the Ukrainian lands. One of them is a short description of 20 parishes functioning in this area at the end of the 18th century. The description was prepared for the needs of Mogilev consistory officials, after these parishes were annexed to the Mogilev archdiocese in 1798. It was compiled a year later, based on parish priests› accounts and dean’s visitation records. On the basis of this description and other newly discovered sources from that time, it is possible to find out essential information about the parishes described, the time of their foundation, their founders, benefices, churches, clergy, number of believers and the towns where parish schools and hospitals were functioning at that time.
Beyaz Gemi Faciası ve Orta Çağ İngilteresi’nde Veraset Sorunu
Authors: GÖKBAYIR Gökmen Günay , DURMAZ Sayime
Published: December 2023

1120 yılının Kasım ayında Normandiya kıyısındaki Barfleur'dan hareket ederek İngiliz Kanalı’nı geçmek isteyen Beyaz Gemi talihsiz bir kaza sonucunda batmıştı. İngiltere tarihinin en dramatik gemi kazalarından biri olan bu hadisenin sonucunda neredeyse yolcuların ve mürettebatın tamamı hayatını kaybetmişti. Büyük çoğunluğu İngiltere ve Normandiya’nın soylularından oluşan yolcular arasında, Fransa Kralı VI. Louis tarafından Normandiya Dukalığı için veliahtlığı henüz tanınmış olan ve İngiltere tahtının yasal vârisi William Ætheling de buluyordu. William, İngiltere kralı ve Normandiya dükü I. Henry’nin meşru tek erkek evladıydı. Henry’nin yirmiden fazla gayrimeşru çocuğu olsa da, William dışında tek meşru çocuğu Kutsal Roma-Germen İmparatoru V. Heinrich ile evli olan kızı Matilda’ydı. 1106 yılından beri esaret altında tuttuğu abisi Robert Curthose’un oğlu William Clito ise hem Normandiya hem de İngiltere tahtını tehdit ediyordu. Üstelik Henry, Beyaz Gemi kazasından iki sene önce eşi Kraliçe Edith-Matilda’yı kaybetmişti ve tekrar evlenmemişti. Henry Orta Çağ Avrupası’nda tahtta oturan bir kralın başına gelebilecek en kötü durumlardan biri ile karşı karşıyaydı; kendisinden sonra tahtını ve topraklarını bırakabileceği bir vâris artık yoktu. Bu duruma çare bulmak adına Henry yeni bir evlilik dahi yapmış fakat ilerleyen yaşından dolayı tekrar çocuk sahibi olamamıştı. Kazadan beş sene sonra V. Heinrich’in ölümü ile kızı Matilda’nın dul kalması, İngiltere Kralı Henry’ye emsaline rastlanılmamış bir fikir verdi ve kızını İngiltere tahtının yasal vârisi ilan etmeye çalıştı; fakat bu o kadar kolay olmayacaktı. Bu çalışma 1120 yılında gerçekleşen Beyaz Gemi kazası ve sonrasında ortaya çıkan veraset sorununu çözmek için I. Henry’nin gayretlerini çağdaş kaynakların yardımı ile incelemeyi amaçlamaktadır.
Thanatological Motives in the Novel “The Book Thief” by Marcus Zusak
Authors:   Orenburg State University, Netkachyova Ekaterina D. , Hrushcheva Oksana A. ,   Orenburg State University
Published: December 2023

The article considers the problem of thanatological motives in modern foreign literature and namely in M. Zusak’s Book Thief. The study revealed that thanatological motives provide for the content and plot development of the novel. M. Zusak depicts Death as a living creature similar to humans, including it into the system of images and characters. Thanatological motives interpretation is dynamic, natural and bright in multiple shades.