bluuebunny/crossref_metadata_2025 huggingface dataset:
Gut-brain pathogenesis of post-acute COVID-19 neurocognitive symptoms
Authors: Plummer Allison M. , Matos Yvette L. , Lin Henry C. , Ryman Sephira G. , Birg Aleksandr , Quinn Davin K. , Parada Alisha N. , Vakhtin Andrei A.
Published: September 2023

Approximately one third of non-hospitalized coronavirus disease of 2019 (COVID-19) patients report chronic symptoms after recovering from the acute stage of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Some of the most persistent and common complaints of this post-acute COVID-19 syndrome (PACS) are cognitive in nature, described subjectively as “brain fog” and also objectively measured as deficits in executive function, working memory, attention, and processing speed. The mechanisms of these chronic cognitive sequelae are currently not understood. SARS-CoV-2 inflicts damage to cerebral blood vessels and the intestinal wall by binding to angiotensin-converting enzyme 2 (ACE2) receptors and also by evoking production of high levels of systemic cytokines, compromising the brain’s neurovascular unit, degrading the intestinal barrier, and potentially increasing the permeability of both to harmful substances. Such substances are hypothesized to be produced in the gut by pathogenic microbiota that, given the profound effects COVID-19 has on the gastrointestinal system, may fourish as a result of intestinal post-COVID-19 dysbiosis. COVID-19 may therefore create a scenario in which neurotoxic and neuroinflammatory substances readily proliferate from the gut lumen and encounter a weakened neurovascular unit, gaining access to the brain and subsequently producing cognitive deficits. Here, we review this proposed PACS pathogenesis along the gut-brain axis, while also identifying specific methodologies that are currently available to experimentally measure each individual component of the model.
Solid–liquid equilibria of Sorel phases and Mg(OH)2 in the system Na-Mg-Cl-OH-H2O. Part II: Pitzer modeling
Authors: Freyer Daniela , Pannach Melanie , Voigt Wolfgang
Published: September 2023

For geochemical calculations of solubility equilibria between Sorel phases, Mg(OH)2, and oceanic salt solutions, the polythermal THEREDA dataset (based on the HMW model at 25°C) was extended. With both models, H+ solution concentrations in equilibrium with Mg(OH)2(s) and the 3-1-8 Sorel phase at 25°C can be calculated in good agreement. In contrast, calculated OH− solution concentrations do not agree. Using the solubility constants (lg Ks) determined up to 60°C in Part I of this work, together with available solubility isotherms up to 120°C, temperature functions for the 3-1-8 phase (25°C–100°C), 2-1-4 phase (60°C–120°C), and 9-1-4 phase (100°C–120°C) were derived. In order to accurately model the OH− solution concentrations, it was necessary to implement the solution species Mg3(OH)42+ (∆RGm° temperature function) in addition to the MgOH+ already contained in the previous model. Finally, fitting Pitzer mixing coefficients for both species now allow the calculation of the solubility equilibria of Mg(OH)2(s) and the Sorel phases in agreement with the experimental data in the Mg-Cl-OH-H2O and Na-Mg-Cl-OH-H2O systems.
Sleep behavior and daily activity levels in people with metabolic syndrome: effect of 1 year of metformin treatment
Authors: Bruno Eleonora , Mulè Antonino , Galasso Letizia , Castelli Lucia , Baldassari Ivan , Oliverio Andreina , Venturelli Elisabetta , Berrino Franco , Montaruli Angela , Roveda Eliana , Pasanisi Patrizia
Published: September 2023

Impaired sleep and low daily activity levels increase the risk of developing metabolic syndrome (MS). Metformin (MET), an insulin sensitizer drug, is effective in regressing MS and has been recently studied as an adjuvant agent for managing sleep disorders. The present study aimed to assess whether 1,700 mg/day of MET treatment modifies sleep and daily activity levels in people with MS evaluated by Rest-Activity circadian Rhythm (RAR), which is the expression of 24 h of spontaneous activity parameters. A total of 133 subjects with MS, randomized into the MET (n = 65) or placebo (PLA, n = 68) group, underwent a clinical/anthropometric examination and carried out a continuous 7-day actigraphic monitoring to investigate sleep and RAR parameters at baseline and after 1 year of intervention. After 1 year of intervention, 105 subjects were analyzed. The MET group showed greater anthropometric and metabolic improvements compared with placebo, with a significant reduction in weight (p = 0.01), body mass index (p = 0.01), waist circumference (p = 0.03), and glucose (p < 0.001). With regard to sleep parameters, the MET group showed a significant increase in actual sleep time (p = 0.01) and sleep efficiency (p = 0.04) compared with placebo. There were no significant changes reported in the RAR parameters. Our study suggests that MET might be used as an adjuvant treatment for sleep disorders in people with MS.
The second docetaxel rechallenge for metastatic castration-resistant prostate cancer: a case report
Authors: Ning Wei , Chang Pengkang , Zheng Ji , He Fan
Published: September 2023

Background

Docetaxel combined with prednisone plus androgen deprivation therapy (ADT) is the preferred treatment option for metastatic hormone-sensitive prostate cancer (mHSPC) or metastatic castration-resistant prostate cancer (mCRPC). With the development of next-generation hormonal agents (NHAs) and poly (ADP-ribose) polymerase (PARP) inhibitors, more aggressive first-line or later-line treatment strategies have been added to the treatment of mHSPC and mCRPC. However, docetaxel rechallenge (DR) has special clinical significance in patients with “docetaxel-sensitive” prostate cancer. There are no reports on the efficacy and safety of the second DR in mCRPC patients.

Case presentation

We report one patient diagnosed with mCRPC who showed progression-free survival (PFS) and overall survival (OS) benefits and safety and good lower urinary tract function after the second DR.

Conclusion

The second DR as a potential alternative later-line treatment strategy should be considered for patients with mCRPC who worry about the high economic burden of multigene molecular testing and PARP inhibitors as well as repeated prostate needle biopsy.
Synthetic MRI plus FSE-PROPELLER DWI for differentiating malignant from benign head and neck tumors: a preliminary study
Authors: Wen Baohong , Zhang Zanxia , Zhu Jing , Liu Liang , Liu Zijun , Ma Xiaoyue , Wang Kaiyu , Xie Lizhi , Zhang Yong , Cheng Jingliang
Published: September 2023

Background

Preoperative classification of head and neck (HN) tumors remains challenging, especially distinguishing early cancerogenic masses from benign lesions. Synthetic MRI offers a new way for quantitative analysis of tumors. The present study investigated the application of synthetic MRI and stimulus and fast spin echo diffusion-weighted imaging with periodically rotated overlapping parallel lines with enhanced reconstruction (FSE-PROPELLER DWI) to differentiate malignant from benign HN tumors.

Materials and methods

Forty-eight patients with pathologically confirmed HN tumors were retrospectively recruited between August 2022 and October 2022. The patients were divided into malignant (n = 28) and benign (n = 20) groups. All patients were scanned using synthetic MRI and FSE-PROPELLER DWI. T1, T2, and proton density (PD) values were acquired on the synthetic MRI and ADC values on the FSE-PROPELLER DWI.

Results

Benign tumors (ADC: 2.03 ± 0.31 × 10-3 mm2/s, T1: 1741.13 ± 662.64 ms, T2: 157.43 ± 72.23 ms) showed higher ADC, T1, and T2 values compared to malignant tumors (ADC: 1.46 ± 0.37 × 10-3 mm2/s, T1: 1390.06 ± 241.09 ms, T2: 97.64 ± 14.91 ms) (all P<0.05), while no differences were seen for PD values. ROC analysis showed that T2+ADC (cut-off value, > 0.55; AUC, 0.950) had optimal diagnostic performance vs. T1 (cut-off value, ≤ 1675.84 ms; AUC, 0.698), T2 (cut-off value, ≤ 113.24 ms; AUC, 0.855) and PD (cut off value, > 80.67 pu; AUC, 0.568) alone in differentiating malignant from benign lesions (all P<0.05); yet, the difference in AUC between ADC and T2+ADC or T2 did not reach statistical significance.

Conclusion

Synthetic MRI and FSE-PROPELLER DWI can quantitatively differentiate malignant from benign HN tumors. T2 value is comparable to ADC value, and T2+ADC values could improve diagnostic efficacy., apparent diffusion coeffificient, head and neck tumors
High serum miR-223-3p expression level predicts complete response and prolonged overall survival in multiple myeloma patients undergoing autologous hematopoietic stem cell transplantation
Authors: Mikulski Damian , Nowicki Mateusz , Dróźdż Izabela , Misiewicz Małgorzata , Kościelny Kacper Piotr , Okoński Karol , Krawiec Kinga , Perdas Ewelina , Wierzbowska Agnieszka , Fendler Wojciech
Published: September 2023

Introduction

AHSCT is the treatment of choice for newly diagnosed patients with transplant-eligible multiple myeloma (MM). However, considerable variability in response to autologous hematopoietic stem cell transplantation (AHSCT) results in only 50% of patients achieving complete response (CR) after AHSCT, which is directly associated with improved progression-free and overall survival (OS). In this study, we aimed to investigate the potential predictive role of selected serum miRNAs in MM patients who underwent AHSCT.

Patients and methods

Serum expression level of 6 miRNAs: miR-221-3p, miR-15b-5p, miR-223-3p, miR-320c, miR-361-3p, and miR-150-5p was evaluated in 51 patients who underwent AHSCT. Blood samples were collected at two time points: before conditioning chemotherapy (T1) and fourteen days after transplant (+14) (T2).

Results

All selected miRNAs significantly changed their expression level across the procedure- two were up-regulated after AHSCT: hsa-miR-320c (FC 1.42, p<0.0001) and hsa-miR-361-3p (FC 1.35, p=0.0168); four were down-regulated: hsa-miR-15b-5p (FC 0.53, p<0.0001), hsa-miR-221-3p (FC 0.78, p=0.0004), hsa-miR-223-3p (FC 0.74, p=0.0015) and hsa-miR-150-5p (FC 0.75, p=0.0080). Notably, before AHSCT, hsa-miR-223-3p was down-regulated in International Staging System (ISS) III patients (FC=0.76, p=0.0155), and hsa-miR-320c was up-regulated (FC=1.27, p=0.0470). These differences became non-significant after AHSCT. Eight (15.69%) patients achieved CR before AHSCT and 17 patients (33.33%) at +100 days after AHSCT. In multivariate logistic regression analysis, achievement of CR after induction and hsa-miR-223-3p at T1 were independent predictors of CR after AHSCT. In multivariate Cox regression analysis, hsa-miR-223-3p at T1 expression level was associated with prolonged OS (HR 0.06, 95%CI: 0.00 - 0.99, p=0.0488).

Conclusion

Serum expression of has-miR-223-3p is a predictor of CR and prolonged OS in MM patients undergoing AHSCT.
Integrative medical group visits for patients with chronic pain: results of a pilot single-site hybrid implementation-effectiveness feasibility study
Authors: Roth Isabel , Tiedt Malik , Miller Vanessa , Barnhill Jessica , Chilcoat Aisha , Gardiner Paula , Faurot Keturah , Karvelas Kris , Busby Kenneth , Gaylord Susan , Leeman Jennifer
Published: September 2023

Background

Approximately 20% of adults in the United States experience chronic pain. Integrative Medical Group Visit (IMGV) offers an innovative approach to chronic pain management through training in mindfulness, nutrition, and other mind-body techniques combined with peer support. To date, there are no studies on IMGV implementation, despite its promise as a feasible non-pharmacological intervention for chronic pain management. In this study, we assessed the feasibility of implementing IMGV and assessing its effectiveness for chronic pain.

Methods

Implementation Mapping was used to develop and evaluate implementation strategies for IMGV. Strategies included disseminating educational materials, conducting ongoing training, and conducting educational meetings. IMGV was delivered by three healthcare providers: an allopathic physician, registered yoga teacher, and naturopathic physician. The effectiveness of IMGV on patient health outcomes was assessed through qualitative interviews and a Patient-Reported Outcomes Scale (PROMIS-29). Provider perspectives of acceptability, appropriateness, and feasibility were assessed through periodic reflections (group interviews reflecting on the process of implementation) and field notes. Paired t-tests were used to assess changes between scores at baseline and post intervention. Qualitative data were coded by three experienced qualitative researchers using thematic content analysis.

Results

Of the initial 16 patients enrolled in research, 12 completed at least two sessions of the IMGV. Other than fatigue, there was no statistically significant difference between the pre- and post-scores. Patients reported high satisfaction with IMGV, noting the development of new skills for self-care and the supportive community of peers. Themes from patient interviews and periodic reflections included the feasibility of virtual delivery, patient perspectives on acceptability, provider perspectives of feasibility and acceptability, ease of recruitment, complexity of referral and scheduling process, balancing medical check-in with group engagement, and nursing staff availability.

Conclusions

IMGV was feasible, acceptable, and effective from the perspectives of patients and providers. Although statistically significant differences were not observed for most PROMIS measures, qualitative results suggested that participants experienced increased social support and increased pain coping skills. Providers found implementation strategies effective, except for engaging nurses, due to staff being overwhelmed from the pandemic. Lessons learned from this pilot study can inform future research on implementation of IMGV.
Aqueous Nyctanthes arbortristis and doxorubicin conjugated gold nanoparticles synergistically induced mTOR-dependent autophagy-mediated ferritinophagy in paclitaxel-resistant breast cancer stem cells
Authors: Chittineedi Prasanthi , Pandrangi Santhi Latha , Neira Mosquera Juan Alejandro , Sánchez Llaguno Sungey Naynee , Mohiddin Gooty Jaffer
Published: September 2023

Aim:Nyctanthes arbortristis Linn is a potential anti-diabetic drug that reduces glucose levels by delaying carbohydrate digestion. The tumor microenvironment is characterized by elevated glucose levels that activate various genes, such as mTOR. mTOR plays a critical role in maintaining the hypoxic environment and inhibiting autophagy. Although natural compounds pose fewer side effects, their hydrophobic nature makes these compounds not suitable as therapeutics. Hence, we conjugated aqueous NAT into gold nanoparticles (AuNP) in the current study and evaluated the ability of the chosen drugs to induce cell death in breast cancer cells resistant to Paclitaxel.

Materials and methods: Particle size analyzer, UV-Vis spectrophotometer, FTIR, and XRD were used in the present study to characterize NAT and Doxorubicin encapsulated AuNPs. To check the cytotoxic effect of AuNP-NAT and AuNP-doxorubicin on PacR/MCF-7 stem cells MTT assay was performed. RT-PCR was performed to check the altered expression of ferritinophagy-related genes. The proliferation and migration potential of the cells before and after treatment with the desired drug combinations was evaluated by clonogenic and scratch assays, respectively. Flow cytometry analysis was done to quantify apoptotic bodies and cell cycle arrest. Cellular ROS was determined using DCD-FA staining.

Results and conclusion: NAT and doxorubicin loaded into AuNP showed enhanced stability and induced ferritinophagy in PacR/MCF-7 stem cells. The obtained results suggest that AuNP-NAT, combined with a low AuNP-Doxorubicin nanoconjugate dose, might be an effective anti-neoplastic drug targeting the necroptosis-autophagy axis, thereby reducing the adverse side-effects induced by the conventional chemotherapeutic drugs.
Impact of selective reporting of antimicrobial susceptibility testing report on clinicians’ prescribing behavior of antibiotics
Authors: Wang Ying , Zhang Xinping , Zhou Qian , Xu Xiaojun
Published: September 2023

Background: Selective reporting has important value in antibiotic management. The purpose of this study was to explore the impact of AST selective reporting on prescribing behavior, so as to provide evidence for the implementation and improvement of selective reporting policies in microbiology laboratories at home and abroad.

Methods: A cross-sectional study was conducted in a teaching tertiary hospital in China in July 2021. We designed selective reports and routine reports for urinary tract infections caused by Escherichia coli and lower respiratory tract infections caused by Pseudomonas aeruginosa. Questionnaires were conducted among participants by case vignettes, and 116 valid questionnaires were collected. The appropriateness rate of antibiotic prescription and the prescription rate of drug-resistant antibiotics, cephalosporins, fluoroquinolones, and carbapenems were calculated and compared between the selective reporting group and the routine reporting group in each case.

Results: In most cases, we found that AST selective reporting could increase the appropriateness rate of antibiotic prescription (p < 0.05) and reduce the drug-resistant antibiotic prescription rate (p < 0.01), cephalosporin drug prescription rate (p < 0.05) and fluoroquinolone drug prescription rate (p < 0.01). Although the difference in carbapenems prescription rate was not significant, selective reporting could reduce the number of its prescriptions to some extent.

Conclusion: AST selective reporting can help promote the appropriate use of antibiotics and reduce the use of broad-spectrum antibiotics. It is suggested to develop scientific and effective selective reporting practices and strengthen the two-way communication between clinicians and microbiology laboratories, thereby enabling microbiology laboratories to play a more important role in clinical antimicrobial management.
Natural compounds: Wnt pathway inhibitors with therapeutic potential in lung cancer
Authors: Shen Xuetong , Gao Chundi , Li Huayao , Liu Cun , Wang Longyun , Li Ye , Liu Ruijuan , Sun Changgang , Zhuang Jing
Published: September 2023

The Wnt/β-catenin pathway is abnormally activated in most lung cancer tissues and considered to be an accelerator of carcinogenesis and lung cancer progression, which is closely related to increased morbidity rates, malignant progression, and treatment resistance. Although targeting the canonical Wnt/β-catenin pathway shows significant potential for lung cancer therapy, it still faces challenges owing to its complexity, tumor heterogeneity and wide physiological activity. Therefore, it is necessary to elucidate the role of the abnormal activation of the Wnt/β-catenin pathway in lung cancer progression. Moreover, Wnt inhibitors used in lung cancer clinical trials are expected to break existing therapeutic patterns, although their adverse effects limit the treatment window. This is the first study to summarize the research progress on various compounds, including natural products and derivatives, that target the canonical Wnt pathway in lung cancer to develop safer and more targeted drugs or alternatives. Various natural products have been found to inhibit Wnt/β-catenin in various ways, such as through upstream and downstream intervention pathways, and have shown encouraging preclinical anti-tumor efficacy. Their diversity and low toxicity make them a popular research topic, laying the foundation for further combination therapies and drug development.
Lipid metabolism as a target for cancer drug resistance: progress and prospects
Authors: Wang Zi’an , Wang Yueqin , Li Zeyun , Xue Wenhua , Hu Shousen , Kong Xiangzhen
Published: September 2023

Cancer is the world’s leading cause of human death today, and the treatment process of cancer is highly complex. Chemotherapy and targeted therapy are commonly used in cancer treatment, and the emergence of drug resistance is a significant problem in cancer treatment. Therefore, the mechanism of drug resistance during cancer treatment has become a hot issue in current research. A series of studies have found that lipid metabolism is closely related to cancer drug resistance. This paper details the changes of lipid metabolism in drug resistance and how lipid metabolism affects drug resistance. More importantly, most studies have reported that combination therapy may lead to changes in lipid-related metabolic pathways, which may reverse the development of cancer drug resistance and enhance or rescue the sensitivity to therapeutic drugs. This paper summarizes the progress of drug design targeting lipid metabolism in improving drug resistance, and providing new ideas and strategies for future tumor treatment. Therefore, this paper reviews the issues of combining medications with lipid metabolism and drug resistance.
Mechanisms of angioregression of the corpus luteum
Authors: Monaco Corrine F. , Davis John S.
Published: September 2023

The corpus luteum is a transient ovarian endocrine gland that produces the progesterone necessary for the establishment and maintenance of pregnancy. The formation and function of this gland involves angiogenesis, establishing the tissue with a robust blood flow and vast microvasculature required to support production of progesterone. Every steroidogenic cell within the corpus luteum is in direct contact with a capillary, and disruption of angiogenesis impairs luteal development and function. At the end of a reproductive cycle, the corpus luteum ceases progesterone production and undergoes rapid structural regression into a nonfunctional corpus albicans in a process initiated and exacerbated by the luteolysin prostaglandin F2α (PGF2α). Structural regression is accompanied by complete regression of the luteal microvasculature in which endothelial cells die and are sloughed off into capillaries and lymphatic vessels. During luteal regression, changes in nitric oxide transiently increase blood flow, followed by a reduction in blood flow and progesterone secretion. Early luteal regression is marked by an increased production of cytokines and chemokines and influx of immune cells. Microvascular endothelial cells are sensitive to released factors during luteolysis, including thrombospondin, endothelin, and cytokines like tumor necrosis factor alpha (TNF) and transforming growth factor β 1 (TGFB1). Although PGF2α is known to be a vasoconstrictor, endothelial cells do not express receptors for PGF2α, therefore it is believed that the angioregression occurring during luteolysis is mediated by factors downstream of PGF2α signaling. Yet, the exact mechanisms responsible for angioregression in the corpus luteum remain unknown. This review describes the current knowledge on angioregression of the corpus luteum and the roles of vasoactive factors released during luteolysis on luteal vasculature and endothelial cells of the microvasculature.
Trans-grafting plum pox virus resistance from transgenic plum rootstocks to apricot scions
Authors: Alburquerque Nuria , Pérez-Caselles Cristian , Faize Lydia , Ilardi Vincenza , Burgos Lorenzo
Published: September 2023

Introduction

Trans-grafting could be a strategy to transfer virus resistance from a transgenic rootstock to a wild type scion. However contradictory results have been obtained in herbaceous and woody plants. This work was intended to determine if the resistance to sharka could be transferred from transgenic plum rootstocks to wild-type apricot scions grafted onto them.

Methods

To this end, we conducted grafting experiments of wild- type apricots onto plum plants transformed with a construction codifying a hairpin RNA designed to silence the PPV virus and studied if the resistance was transmitted from the rootstock to the scion.

Results

Our data support that the RNA-silencing-based PPV resistance can be transmitted from PPV-resistant plum rootstocks to non-transgenic apricot scions and that its efficiency is augmented after successive growth cycles. PPV resistance conferred by the rootstocks was robust, already occurring within the same growing cycle and maintained in successive evaluation cycles. The RNA silencing mechanism reduces the relative accumulation of the virus progressively eliminating the virus from the wild type scions grafted on the transgenic resistant PPV plants. There was a preferential accumulation of the 24nt siRNAs in the scions grafted onto resistant rootstocks that was not found in the scions grafted on the susceptible rootstock. This matched with a significantly lower relative accumulation of hpRNA in the resistant rootstocks compared with the susceptible or the tolerant ones.

Discussion

Using transgenic rootstocks should mitigate public concerns about transgenes dispersion and eating transgenic food and allow conferring virus resistance to recalcitrant to transformation cultivars or species.
Narrative-based autobiographical memory interventions for PTSD: a meta-analysis of randomized controlled trials
Authors: Raeder Robert , Clayton Nicola S. , Boeckle Markus
Published: September 2023

Introduction

The aim of this systematic review and meta-analysis is to evaluate the efficacy of narrative-based interventions (NBIs) for individuals with post-traumatic stress disorder (PTSD). Investigating the efficacy of NBIs should yield insight on autobiographical memory (AM) phenomena implicated in PTSD onset and recovery, leading to improved intervention protocols. Furthermore, by analyzing how NBIs influence maladaptive AM distortions, we hope to shed light on the theorized narrative architecture of AM more generally.

Methods

A systematic literature search was conducted according to PRISMA and Cochrane guidelines in MEDLINE, EMBASE, PsychINFO, and PubMed. Additional studies were then also identified from the reference lists of other relevant literature and considered for inclusion. Studies were then evaluated for adherence to the inclusion/exclusion criteria and assessed for risk of bias. Various meta-analyses were performed on included studies to understand how NBIs may or may not influence the overall effect size of treatment.

Results

The results of the meta-analysis of 35 studies, involving 2,596 participants, suggest that NBIs are a viable and effective treatment option for PTSD, yielding a statistically significant within-group effect size and decrease in PTSD symptomatology at both post-treatment [g = 1.73, 95% CI (1.23–2.22)] and 3–9 month follow-up assessments [g = 2.33, 95% CI (1.41–3.26)]. Furthermore, the difference in effect sizes between NBIs compared to active and waitlist controls was statistically significant, suggesting that NBIs are superior. Sub-analyses showed that NET provided a stronger effect size than FORNET, which may be due to the nature of the traumatic event itself and not the treatment protocol. While evidence of small study and publication bias was present, a weight-function model and trim-and-fill method suggested it was not influencing the overall results.

Discussion

This meta-analysis presents strong evidence supporting the use of NBIs in the treatment of PTSD. Clear similarities can be identified between NBIs included in this analysis that make them distinct from non-NBI interventions, which are reviewed in the discussion. Controlled comparisons between NBIs and non-NBIs would help to further understand AM mechanisms of action implicated in recovery and how various interventions facilitate them. Future research should also aim to elucidate the full range of AM impairment in individuals with PTSD to gain insight on how other memory capabilities, such as the ability to mentally simulate the future, are implicated in the pathogenesis of PTSD.
Measuring the building blocks of everyday cognition: executive functions and relational reasoning
Authors: Richland Lindsey Engle , Zhao Hongyang
Published: September 2023

Measurement of the building blocks of everyday thought must capture the range of different ways that humans may train, develop, and use their cognitive resources in real world tasks. Executive function as a construct has been enthusiastically adopted by cognitive and education sciences due to its theorized role as an underpinning of, and constraint on, humans’ accomplishment of complex cognitively demanding tasks in the world, such as identifying problems, reasoning about and executing multi-step solutions while inhibiting prepotent responses or competing desires. As EF measures have been continually refined for increased precision; however, they have also become increasingly dissociated from those everyday accomplishments. We posit three implications of this insight: (1) extant measures of EFs that reduce context actually add an implicit requirement that children reason using abstract rules that are not accomplishing a function in the world, meaning that EF scores may in part reflect experience with formal schooling and Western, Educated, Industrialized, Rich, Democratic (WEIRD) socialization norms, limiting their ability to predict success in everyday life across contexts, (2) measurement of relational attention and relational reasoning have not received adequate consideration in this context but are highly aligned with the key aims for measuring EFs, and may be more aligned with humans’ everyday cognitive practices, but (3) relational attention and reasoning should be considered alongside rather than as an additional EF as has been suggested, for measurement clarity.
The bigger the threat, the longer the gaze? A cross-cultural study of Somalis and Czechs
Authors: Štolhoferová Iveta , Frynta Daniel , Janovcová Markéta , Rudolfová Veronika , Elmi Hassan Sh Abdirahman , Rexová Kateřina , Berti Daniel Alex , Král David , Sommer David , Landová Eva , Frýdlová Petra
Published: September 2023

High fear reaction, preferential attention, or fast detection are only a few of the specific responses which snakes evoke in humans. Previous research has shown that these responses are shared amongst several distinct cultures suggesting the evolutionary origin of the response. However, populations from sub-Saharan Africa have been largely missing in experimental research focused on this issue. In this paper, we focus on the effect of snake threat display on human spontaneous attention. We performed an eye-tracking experiment with participants from Somaliland and the Czechia and investigated whether human attention is swayed towards snakes in a threatening posture. Seventy-one Somalis and 71 Czechs were tested; the samples were matched for gender and comparable in age structure and education level. We also investigated the effect of snake morphotype as snakes differ in their threat display. We found that snakes in a threatening posture were indeed gazed upon more than snakes in a relaxed (non-threatening) posture. Further, we found a large effect of snake morphotype as this was especially prominent in cobras, less in vipers, and mostly non-significant in other morphotypes. Finally, despite highly different cultural and environmental backgrounds, the overall pattern of reaction towards snakes was similar in Somalis and Czechs supporting the evolutionary origin of the phenomenon. We concluded that human attention is preferentially directed towards snakes, especially cobras and vipers, in threatening postures.
Using focus groups to inform a brief video intervention to reduce public stigma toward Black youth living with psychosis
Authors: Jankowski Samantha E. , Pope Leah G. , Smith Stephen , Pagdon Shannon , Dixon Lisa B. , Amsalem Doron
Published: September 2023

Objective

Black individuals living with psychosis are at risk for stigma and marginalization due to systematic discrimination and barriers to receiving treatment. Social contact-based interventions have the potential to reduce stigma; however, interventions with elements specific to the experiences of Black youth are limited. Therefore, we aimed to gather input from Black youth living with psychosis to develop a social contact-based, brief video intervention to reduce public stigma toward Black youth with psychosis.

Methods

Two 90-min focus groups were conducted with seven young Black individuals ages 18–30 with First Episode Psychosis from OnTrackNY. Participants were asked about their experiences of stigma and racial discrimination, and their perspectives on a video intervention. Focus group transcripts were analyzed using thematic content analysis.

Results

Themes that emerged included: the salience of stigma and racial experiences for some participants and not others; the linking of religiosity and symptoms in Black communities; the importance of taking responsibility for recovery as a coping strategy to counteract stigma; and mixed views on creating a video intervention specific to Black youth.

Conclusion

Meaningful and empowering involvement of individuals with lived experience of psychosis is essential to create stigma reducing interventions. Input from Black youth living with psychosis assisted in developing a culturally tailored brief video-based intervention to reduce public stigma toward Black youth with psychosis that included information about the protagonist’s experience of race and mental illness, specifically family, religious, and community-based experiences.
Association between different dimensions of anger and symptoms of post-traumatic stress disorder in at-risk cardiovascular patients during the COVID-19 pandemic
Authors: Nesic Mihailo , Vogel Julia , Krüger Jan Philipp , Wenzel Werner , Sahebi Ali , Rassaf Tienush , Siebermair Johannes , Wesemann Ulrich
Published: September 2023

Introduction

The common connecting factor between PTSD and cardiovascular diseases lies in the disruption of the stress processing system. The COVID-19 pandemic has led to an increase in stress levels worldwide. Due to the life-threatening situation of affected risk patients, this also led to the accumulation of post-traumatic stress symptoms (PTSS). The influence of anger on cardiovascular diseases has hardly been investigated so far. The focus of this study is on anger regulation in cardiovascular risk patients. The COVID-19 pandemic is considered as an additional stressor in this study, but not as a separate entity. The hypothesis is that individuals with inward anger are more prone to post-traumatic stress disorder (PTSD).

Methods

As part of the routine examination, all patients who were hospitalized between January 1st, 2021 and May 31st, 2022 with high-risk cardiovascular diseases were included. A total of N = 153 (84.1%) subjects participated in the study. On admission, anger (STAXI-2) and PTSD (PCL-5) were assessed using questionnaires. The relationship between different domains of anger and PTSS was examined.

Results

Inwardly directed anger was more pronounced in this population than in a standard sample (+1 SD) and had a significant impact on the presence of PTSD (B = −0.72, p < 0.001). Additionally, correlations were found between inward-directed anger and PTSD, as well as all other anger expressions studied and the PTSD total score.

Discussion

It can be assumed that anger and its regulation are relevant factors for both cardiac diseases and PTSD. The study results can be used for prevention, rehabilitation and therapeutic measures. However, the impact of inner anger on PTSD is theoretical and based on statistical testing. A confirmatory longitudinal study is needed to substantiate these results.
Combining different points of view on plant descriptions: mapping agricultural plant roles and biological taxa
Authors: Amardeilh Florence , Aubin Sophie , Bernard Stephan , Bravo Sonia , Bossy Robert , Faron Catherine , Michel Franck , Raphel Juliette , Roussey Catherine
Published: September 2023

This article describes our study on the alignment of two complementary knowledge graphs useful in agriculture: the thesaurus of cultivated plants in France named French Crop Usage (FCU) and the French national taxonomic repository TAXREF for fauna, flora, and fungi. FCU describes the usages of plants in agriculture: “tomatoes” are crops used for human food, and “grapevines” are crops used for human beverage. TAXREF describes biological taxa and associated scientific names: for example, a tomato species may be “Solanum lycopersicum” or a grapevine species may be “Vitis vinifera”. Both knowledge graphs contain vernacular names of plants but those names are ambiguous. Thus, a group of agricultural experts produced some mappings from FCU crops to TAXREF taxa. Moreover, new RDF properties have been defined to declare those new types of mapping relations between plant descriptions. The metadata for the mappings and the mapping set are encoded with the Simple Standard for Sharing Ontological Mappings (SSSOM), a new model which, among other qualities, offers means to report on provenance of particular interest for this study. The produced mappings are available for download in Recherche Data Gouv, the federated national platform for research data in France.
Characterization of planetary regolith simulants for the research and development of space resource technologies
Authors: Long-Fox Jared M. , Britt Daniel T.
Published: September 2023

Human planetary exploration and colonization efforts are reliant on the ability to safely interact with planetary surfaces and to leverage local regolith as a resource. The high-cost and risk-intensive nature of establishing planetary infrastructure and resource utilization facilities necessitates risk reduction through laboratory-based research and development of space resource acquisition, processing, and extraction technologies using appropriate, well-characterized, mineral-based regolith simulants. Such simulants enable the planetary exploration and resource utilization communities to test large-scale technologies and methodologies for a relatively low cost as an alternative to scarce and expensive returned samples. The fidelity of a regolith simulant for any application is, in part, determined by the mineralogical composition and particle size distribution. The importance of composition is well established for in situ resource utilization studies sensitive to geochemical properties but tends to be ignored in studies concerned with physical properties. Neglecting to consider mineralogy reduces the fidelity of a simulant since each mineral species has its own unique grain density, preferred grain geometry, and intergranular forces, all of which affect the physical properties of the simulant (e.g., shear strength, bearing strength, bulk density, thermal and electrical properties, magnetic properties). Traditionally, regolith simulants have been limited in quantity and availability; Exolith Lab remedies these problems by designing simulants in a constrained maximization approach to fidelity relative to cost, material availability, and safety. Exolith Lab simulants are designed to approximate the mineralogy and particle size ranges of the planetary regolith being simulated, with composition constrained by remote sensing observations and/or returned sample analyses. With facilities and equipment capable of high-volume simulant production, Exolith Lab offers standard simulants in bulk that are readily available for purchase and shipment. This work reviews the production methods, equipment, and materials used to create Exolith Lab simulants, provides compositional data, particle size data, and applications for each standard lunar, Martian, and asteroid simulant that Exolith Lab offers.
Integrated stakeholder-centered tourism crisis
Authors: Pennington-Gray Lori , Basurto-Cedeno Estefania
Published: September 2023

Introduction

The present work demonstrates how non-traditional tourism stakeholders' inclusion in planning and decision-making improves connectivity and helps to achieve resilience in rural tourist destinations. The geographical and temporal context for the study is the sector of El Balsamo in Manabi-Ecuador, during the COVID-19 pandemic.

Method

The methodology applied is a case study with data collection through interviews and applying the MERITS method to identify recurring themes when various stakeholders' opinions are included.

Results and discussion

The results of this study show the importance of inclusion and effective communication in building trust and long-term alliances in destination recovery processes. This study makes evident how the creation of networks and partnerships leveraged on effective communication and the prioritization of common objectives allows the permanence of these networks even after the crisis has been overcome.
Utilization of malted barley flour as replacement of wheat flour to improve technological, rheological, physicochemical, and organoleptic parameters of fortified breads
Authors: Aslam Jawed , Hussain Ashiq , Mueen Ud-Din Ghulam , Kausar Tusneem , Siddique Tahira , Kabir Khurram , Gorsi Faiza Iftikhar , Haroon Haseeb , Nisar Rizwan , Noreen Saima , Rocha João Miguel , Ozogul Fatih , Esatbeyoglu Tuba , Korma Sameh A.
Published: September 2023

Introduction

Flours from cereal grains have the potential to be used in the production of bakery products, especially breads, and the addition of other non–wheat plant materials in the form of flours, extracts and malts has always been the area of interest for food producers.

Methods

In this research work, barley grains were converted into barley malt flour (BMF), by adopting a series of processes, including steeping, germination, kilning, drying and milling. With the aim of compensating the role of commercial bread improvers, wheat flour was replaced at 0, 2.5, 5, 7.5, and 10% levels with BMF, to study the effect of BMF on physicochemical and sensory characteristics of bread.

Results and discussion

Chemical analysis of flours revealed that ash, fat, moisture, protein and fibers were found greater in BMF and BMF–incorporated composite flours, as compared to wheat flour. Significant increases in water absorption and decrease in dough stability, dough development time and falling number were noticed, as a result of an increase in the replacement level of BMF. Water absorption of control dough was 58.03%, which increased to 58.77% in composite flour having 10% BMF, whereas dough development time, dough stability and α–amylase activity of control, were 6.97 min, 12 min, and 736 s, respectively, which were decreased to 3.83 min, 4.73 min, and 360 s, respectively in composite flour having 10% BMF. The internal and external characteristics of breads obtained the best sensorial score at 5% replacement level of BMF, and deterioration in the quality of breads was noticed, as the level of BMF was further increased to 7.5 and 10%. Hence, breads developed with 5% BMF and 95% wheat flour, were not only nutritionally rich, but were also with optimum physical and sensory features. BMF could prove a useful alternate ingredient of wheat flour, and a cost-effective replacement of commercially available bread improvers, in the breads manufacturing process in replacement of synthetic bread improvers.
Opportunities and gaps in conservation incentive programs on California agricultural land
Authors: Lenhardt Julia , Egoh B. N.
Published: September 2023

Agricultural incentive programs promote ecosystem health and biodiversity on California working lands and encourage a multitude of conservation goals. The various objectives, environmental impacts, and financial costs of conservation incentive programs are challenging to assess. The ecosystem services framework is a useful tool for identifying tradeoffs between conservation management options. Here, 52 active incentive programs were reviewed to determine the ecosystem services prioritized by each program in California. Next, the top 20 highest funded federal conservation practices were assessed in terms of their ecosystem service impacts. We found that there is a gap between California’s ecosystem services goals and the ecosystem services that are impacted by federal programs, and that the top funded practices are not necessarily the ones that deliver the best benefits in terms of ecosystem services. This study highlights the gaps between conservation goals and outcomes on California agricultural land, as well as the need for regional conservation monitoring to determine the impacts of incentive programs.
Cropping practices of globe artichoke: a bibliometric study
Authors: Stea Donato , Sellami Mohamed Houssemeddine , Ruta Claudia , Pulvento Cataldo , De Mastro Giuseppe
Published: September 2023

Globe artichoke is a food plant that is gaining increasing interest due to its commercial, nutritional and therapeutic value; research and development in the field of agriculture for this crop encompasses several key areas to enhance cultivation, productivity, and overall sustainability. In this study a bibliometric analysis of literature has been carried out in order to identify research areas and research gaps in cropping management of globe artichoke under field conditions, and to identify new research opportunities. The analysis revealed that published articles on the agronomic practices of globe artichoke under field conditions, is concentrated in Europe (70.56%), followed by North America (10%) and South America (7.22%). On the vastly arid Australian continent, there is a dearth of such studies. Italy, Spain and USA, were the most productive countries in the globe artichoke research field. The analysed papers have also shown that agronomic practices such as irrigation (wastewater and brackish water), fertilization, diseases management and plant breeding are the most studied cropping practices that affect artichoke yield and head quality. Finally, this study highlights the importance of integrating innovative methods like meta-analysis to gain a more holistic comprehension of how agricultural practices impact globe artichoke and to lays the groundwork for future research endeavours.
Comparing the intraoperative and postoperative complications of the scalpel and electrocautery techniques for severing the inner layers of the lumbar disc during discectomy surgery
Authors: Hajilo Parisa , Imani Behzad , Zandi Shirdel , Mehrafshan Ali
Published: September 2023

Background

Due to the sensitivity of the surgical site and a higher probability of injury, the use of a scalpel and electrocautery to create an incision in the spine is discussed. In this study, we will compare the intraoperative and postoperative complications of the scalpel and electrocautery techniques for severing the inner layers of the lumbar disc during discectomy surgery.

Materials and methods

This study was conducted in Iran as a randomized controlled trial with double-blinding (1,401). Sixty candidates for spine surgery were randomly divided into two groups of 30 using electrocautery (A) and a scalpel (B) based on available sampling. The VAS scale was used to assess postoperative pain. The duration of the incision and intraoperative blood loss were recorded. The infection and fluid secretions were determined using the Southampton scoring scale. Utilizing the Manchester scar scale, the wound healing status was evaluated. The SPSS version 16 software was used for data analysis (t-test, Mann–Whitney U, ANOVA).

Results

The electrocautery group had substantially lower bleeding, pain, and wound healing rates than the scalpel group (P > 0.05). However, the electrocautery group had significantly longer surgical times, more secretions, and a higher infection rate than the scalpel group (P > 0.05). In terms of demographic and clinical characteristics, there was no significant difference between the two groups (P < 0.05).

Conclusion

Electrocautery reduces postoperative hemorrhage and, potentially, postoperative pain in patients. However, as the duration of surgery increases, so does the duration of anesthesia, and patient safety decreases. Additionally, the risk of infection increases in the electrocautery group compared to the scalpel group, and the rate of wound healing decreases.

Clinical Trial Registration

https://www.irct.ir/, identifier (IRCT20230222057496N1).