bluuebunny/crossref_metadata_2025 huggingface dataset:
Three-Dimensional Hepatocyte Spheroids: Model for Assessing Chemotherapy in Hepatocellular Carcinoma
Authors: Royo Felix , Garcia-Vallicrosa Clara , Azparren-Angulo Maria , Bordanaba-Florit Guillermo , Lopez-Sarrio Silvia , Falcon-Perez Juan Manuel
Published: May 2024

Background: Three-dimensional cellular models provide a more comprehensive representation of in vivo cell properties, encompassing physiological characteristics and drug susceptibility. Methods: Primary hepatocytes were seeded in ultra-low attachment plates to form spheroids, with or without tumoral cells. Spheroid structure, cell proliferation, and apoptosis were analyzed using histological staining techniques. In addition, extracellular vesicles were isolated from conditioned media by differential ultracentrifugation. Spheroids were exposed to cytotoxic drugs, and both spheroid growth and cell death were measured by microscopic imaging and flow cytometry with vital staining, respectively. Results: Concerning spheroid structure, an active outer layer forms a boundary with the media, while the inner core comprises a mass of cell debris. Hepatocyte-formed spheroids release vesicles into the extracellular media, and a decrease in the concentration of vesicles in the culture media can be observed over time. When co-cultured with tumoral cells, a distinct distribution pattern emerges over the primary hepatocytes, resulting in different spheroid conformations. Tumoral cell growth was compromised upon antitumoral drug challenges. Conclusions: Treatment of mixed spheroids with different cytotoxic drugs enables the characterization of drug effects on both hepatocytes and tumoral cells, determining drug specificity effects on these cell types.
Discrete-Time Impedance Control for Dynamic Response Regulation of Parallel Soft Robots
Authors: Khan Ameer Hamza , Li Shuai
Published: May 2024

Accurately controlling the dynamic response and suppression of undesirable dynamics such as overshoots and vibrations is a vital requirement for soft robots operating in industrial environments. Pneumatically actuated soft robots usually undergo large overshoots and significant vibrations when deactuated because of their highly flexible bodies. These large vibrations not only decrease the reliability and accuracy of the soft robot but also introduce undesirable characteristics in the system. For example, it increases the settling time and damages the body of the soft robot, compromising its structural integrity. The dynamic behavior of the soft robots on deactuation needs to be accurately controlled to increase their utility in real-world applications. The literature on pneumatic soft robots still does not sufficiently address the issue of suppressing undesirable vibrations. To address this issue, we propose the use of impedance control to regulate the dynamic response of pneumatic soft robots since the superiority of impedance control is already established for rigid robots. The soft robots are highly nonlinear systems; therefore, we formulated a nonlinear discrete sliding mode impedance controller to control the pneumatic soft robots. The formulation of the controller in discrete-time allows efficient implementation for a high-order system model without the need for state-observers. The simplification and efficiency of the proposed controller enable fast implementation of an embedded system. Unlike other works on pneumatic soft robots, the proposed controller does not require manual tuning of the controller parameters and automatically calculates the parameters based on the impedance value. To demonstrate the efficacy of the proposed controller, we used a 6-chambered parallel soft robot as an experimental platform. We presented the comparative results with an existing state-of-the-art controller in SMC control of pneumatic soft robots. The experiment results indicate that the proposed controller can effectively limit the amplitude of the undesirable vibrations.
Anorectal Manometry in Pediatric Colorectal Surgical Care
Authors: Wheeler Justin C. , Short Scott S. , Rollins Michael D.
Published: May 2024

Background: Pediatric colorectal specialists care for patients with a variety of defecation disorders. Anorectal (AR) manometry testing is a valuable tool in the diagnosis and management of these children. This paper provides a summary of AR manometry techniques and applications as well as a review of AR manometry findings in pediatric patients with severe defecation disorders referred to a pediatric colorectal center. This is the first study describing multi-year experience using a portable AR manometry device in pediatric patients. Methods: An electronic medical record review was performed (1/2018 to 12/2023) of pediatric patients with defecation disorders who had AR manometry testing. Demographics, diagnostic findings, and outcomes are described. Key Results: A total of 297 unique patients (56.9% male, n = 169) had AR manometry testing. Of these, 72% (n = 188) had dyssynergic defecation patterns, of which 67.6% (n = 127) had fecal soiling prior to treatment. Pelvic rehabilitation (PR) was administered to 35.4% (n = 105) of all patients. A total of 79.5% (n = 58) of the 73 patients that had fecal soiling at initial presentation and completed PR with physical therapy and a bowel management program were continent after therapy. AR manometry was well tolerated, with no major complications. Conclusions: AR manometry is a simple test that can help guide the management of pediatric colorectal surgical patients with defecation disorders. As a secondary finding, PR is a useful treatment for patients with dyssynergic stooling.
Efficacy of Morning Shorter Wavelength Lighting in the Visible (Blue) Range and Broad-Spectrum or Blue-Enriched Bright White Light in Regulating Sleep, Mood, and Fatigue in Traumatic Brain Injury: A Systematic Review
Authors: Chow Chin Moi , Ekanayake Kanchana , Hackett Daniel
Published: May 2024

Traumatic brain injury (TBI) profoundly affects sleep, mood, and fatigue, impeding daily functioning and recovery. This systematic review evaluates the efficacy of morning shorter wavelength lighting in the visible (blue) range and broad-spectrum or blue-enriched bright white light exposure in mitigating these challenges among TBI patients. Through electronic database searches up to May 2023, studies assessing sleep, circadian rhythm, sleepiness, mood, and fatigue outcomes in TBI patients exposed to morning shorter wavelength lighting in the visible (blue) range and broad-spectrum or blue-enriched bright white light were identified. Seven studies involving 309 participants met the inclusion criteria. Results indicated consistent advancement in sleep timing among individuals with mild TBI, alongside improvements in total sleep time, mood, and reduced sleepiness with both types of light exposure, particularly in mild TBI cases. Notably, two studies demonstrated alleviation of fatigue exclusively in severe TBI cases following light exposure. Despite promising findings, evidence remains limited, emphasizing the need for future research with standardized protocols to confirm the potential and optimize the benefits of light therapy for TBI recovery.
Predicting Community Participation in Passive Pest Surveillance
Authors: Kaine Geoff , Wright Vic , Mason Norman W. H.
Published: May 2024

Predicting the willingness of people to engage in passive surveillance is crucial to the success of community-based efforts to manage invasive species and conserve native biodiversity. We draw on the marketing concept of involvement, which reflects the personal importance of an issue or behaviour, to understand and measure the motivation of members of the public to engage in passive surveillance. The usefulness of this concept was tested by analysing the responses of householders to surveys about their willingness to engage in passive surveillance for a purely environmental pest, Red-eared Slider Turtles (Trachemys scripta elegans), and their willingness to engage in passive surveillance for an economic and environmental pest, Argentine Ants (Linepithema humile), in New Zealand. We found that involvement influenced intentions, attitudes and surveillance behaviour for both invasive pests. We discussed the implications of these findings for (i) choosing between a surveillance strategy based on recruiting and training highly motivated members of the public and a strategy based on passive surveillance by any member of the public; (ii) growing the potential for passive surveillance by either increasing involvement with preventing the spread of a pest or increasing involvement with surveillance activities themselves; and (iii) determining the importance of convenient reporting mechanisms in promoting consistent reporting.
Defence against Side-Channel Attacks for Encrypted Network Communication Using Multiple Paths
Authors: Haywood Gregor Tamati , Bhatti Saleem Noel
Published: May 2024

As more network communication is encrypted to provide data privacy for users, attackers are focusing their attention on traffic analysis methods for side-channel attacks on user privacy. These attacks exploit patterns in particular features of communication flows such as interpacket timings and packet sizes. Unsupervised machine learning approaches, such as Hidden Markov Models (HMMs), can be trained on unlabelled data to estimate these flow attributes from an exposed packet flow, even one that is encrypted, so it is highly feasible for an eavesdropper to perform this attack. Traditional defences try to protect specific side channels by modifying the packet transmission for the flow, e.g., by adding redundant information (padding of packets or use of junk packets) and perturbing packet timings (e.g., artificially delaying packet transmission at the sender). Such defences incur significant overhead and impact application-level performance metrics, such as latency, throughput, end-to-end delay, and jitter. Furthermore, these mechanisms can be complex, often ineffective, and are not general solutions—a new profile must be created for every application, which is an infeasible expectation to place on software developers. We show that an approach exploiting multipath communication can be effective against HMM-based traffic analysis. After presenting the core analytical background, we demonstrate the efficacy of this approach with a number of diverse, simulated traffic flows. Based on the results, we define some simple design rules for software developers to adopt in order to exploit the mechanism we describe, including a critical examination of existing communication protocol behavior.
Spatio-Temporal Variation in Cyanobacteria and Epiphytic Algae of Thalassia testudinum in Two Localities of Southern Quintana Roo, Mexico
Authors: Nava-Olvera Rocio , Mateo-Cid Luz Elena , González-Contreras Itzel , Mendoza-González Ángela Catalina
Published: May 2024

The leaves of Thalassia testudinum provide an ideal substrate for the establishment of small-sized algae with different morphologies that are abundant and diverse. There are few studies on epiphytism in Mexico, and most of them are floristic lists. The objective of this study was to analyze the taxonomic and morphofunctional composition of epiphytes in three climatic seasons, and their relationship with the phorophyte T. testudinum in two localities, El Uvero and Santa Rosa, in the south of Quintana Roo; three transects and fifteen quadrants were set in June and December (2014) and April (2015). A total of 84 epiphytic species were identified: 27 corresponded to Cyanobacteria, 10 to Phaeophyceae, 9 to Chlorophyta, and 38 to Rhodophyta. The highest specific richness was observed in Santa Rosa (73 species). The dry and summer rains seasons share a higher number of species compared to the winter rainy season. The crusty algae Hydrolithon farinosum was the dominant and most persistent species; in addition, filamentous algae presented great specific richness and coverage due to their morphology and reproductive strategies, which allowed them to successfully establish themselves on the phorophyte. This is related to the ecological succession of the epiphytes and seagrass phenology.
Challenges That Impact the Development of a Multi-Generational Low-Carbon Passive House in a Small City
Authors: Wehbi Hanan , Messadi Tahar
Published: May 2024

The impact of the building and construction sector on climate change is becoming more important and recognized. Multiple initiatives around the globe have been utilized to design and develop residential structures, aiming to reduce energy consumption and carbon emissions; yet, there are several barriers to effective construction processes. This research outlines the gaps and barriers encountered by key stakeholders that were engaged during the preconstruction phase of a three-story multi-generational low-impact Passive House in Fayetteville, Arkansas. Through direct observation and open-ended interviews, the primary data are collected, and secondary data from a comprehensive literature review are detailed to capture the challenges faced during different phases of the implementation of sustainable residential dwellings. This study highlights the limited knowledge and experience in sustainable building design as a common barrier among participants along with the insufficiency of the regulatory framework governing adopted building codes in Arkansas, in facilitating sustainable building design implementation. These challenges, among others, are then thoroughly examined, and recommendations to address them are described.
Interventions to Reduce Intra-Operative and Post-Operative Pain Associated with Routine Dental Procedures in Children: A Systematic Review and Meta-Analysis
Authors: Alzubaidi Mohammed A. , Drummond Bernadette K. , Wu Jianhua , Jones Adam , Aggarwal Vishal R.
Published: May 2024

Objective: implementing appropriate pharmacological and non-pharmacological interventions to alleviate pain related to routine dental procedures in paediatric patients could enhance children’s ability to manage dental care. The aim of this review was to investigate the effectiveness of and provide recommendations for interventions that can be used to reduce intra-operative and post-operative pain associated with routine paediatric dental procedures. Methods: A systematic review of randomised controlled clinical trials (RCT) was conducted. Multiple electronic databases were systematically searched. The Cochrane risk-of-bias tool for RCTs was used to evaluate the quality of the included studies. A meta-analysis was performed to determine the effectiveness of the interventions using the Cohen’s d standardised mean differences (SMD) and 95% confidence intervals (CIs) for continuous outcomes. The GRADE tool was used to assess the certainty of evidence to make recommendations. Results: The review included forty-five RCTs comprising 3093 children. Thirty-seven RCTs were included in the meta-analysis, which showed the effectiveness of behavioural interventions (SMD = −0.50, 95% CI −0.83 to −0.18), mechanoreceptor and thermal receptor stimulation (SMD = −1.38, 95% CI −2.02 to −0.73) for intra-operative pain, and pre-emptive oral analgesics (SMD = −0.77, 95% CI −1.21 to −0.33) for reducing post-operative pain in children receiving routine dental care. Conclusion: The GRADE results for these interventions were strong recommendation (IB) for their use, based on moderate evidence and their benefits far outweighing the harm, and they can be delivered readily with minimal training to reduce the pain experience of paediatric patients.
HHPSO: A Heuristic Hybrid Particle Swarm Optimization Path Planner for Quadcopters
Authors: Lou Jiabin , Ding Rong , Wu Wenjun
Published: May 2024

Path planning for quadcopters has been proven to be one kind of NP-hard problem with huge search space and tiny feasible solution range. Metaheuristic algorithms are widely used in such types of problems for their flexibility and effectiveness. Nevertheless, most of them cannot meet the needs in terms of efficiency and suffer from the limitations of premature convergence and local minima. This paper proposes a novel algorithm named Heuristic Hybrid Particle Swarm Optimization (HHPSO) to address the path planning problem. On the heuristic side, we use the control points of cubic b-splines as variables instead of waypoints and establish some heuristic rules during algorithm initialization to generate higher-quality particles. On the hybrid side, we introduce an iteration-varying penalty term to shrink the search range gradually, a Cauchy mutation operator to improve the exploration ability, and an injection operator to prevent population homogenization. Numerical simulations, physical model-based simulations, and a real-world experiment demonstrate the proposed algorithm’s superiority, effectiveness and robustness.
How Do Primary and Early Secondary School Students Report Dealing with Positive and Negative Achievement Emotions in Class? A Mixed-Methods Approach
Authors: Schlesier Juliane , Raufelder Diana , Ohmes Laura , Moschner Barbara
Published: May 2024

Students experience both positive and negative emotions during lessons. However, little research has been conducted into students’ perspectives on how they deal with these emotions. For this reason, the current study aimed to investigate how students perceive, deal with, and interact in emotional classroom situations, using a mixed-methods approach. In Study 1, 28 primary school children in the fourth grade drew pictures of achievement-emotion situations and were subsequently interviewed. In a three-step analysis process, students’ drawings and interviews were analysed using open coding and content analysis. In Study 2, 635 students from 38 primary and secondary schools in northern Germany reported (via the DECCS questionnaire) their appraisals, achievement emotions, emotion regulation behaviour, and desired teacher support regarding two case vignettes: one involving a learning situation and the other a performance situation. The results of Study 1 reveal that peers play a crucial role in how students deal with positive emotions in class. The structural equation model of Study 2 shows that almost all pathways between emotion regulation behaviour (maladaptive as well as adaptive) and students’ desired teacher behaviour in the form of praise and support are significant. The results of both studies indicate that social support (i.e., peer interactions and teacher support) is crucial in how students deal with both positive and negative achievement emotions in class.
Periodic Transformer Encoder for Multi-Horizon Travel Time Prediction
Authors: Lin Hui-Ting Christine , Tseng Vincent S.
Published: May 2024

In the domain of Intelligent Transportation Systems (ITS), ensuring reliable travel time predictions is crucial for enhancing the efficiency of transportation management systems and supporting long-term planning. Recent advancements in deep learning have demonstrated the ability to effectively leverage large datasets for accurate travel time predictions. These innovations are particularly vital as they address both short-term and long-term travel demands, which are essential for effective traffic management and scheduled routing planning. Despite advances in deep learning applications for traffic analysis, the dynamic nature of traffic patterns frequently challenges the forecasting capabilities of existing models, especially when forecasting both immediate and future traffic conditions across various time horizons. Additionally, the area of long-term travel time forecasting still remains not fully explored in current research due to these complexities. In response to these challenges, this study introduces the Periodic Transformer Encoder (PTE). PTE is a Transformer-based model designed to enhance traffic time predictions by effectively capturing temporal dependencies across various horizons. Utilizing attention mechanisms, PTE learns from long-range periodic traffic data for handling both short-term and long-term fluctuations. Furthermore, PTE employs a streamlined encoder-only architecture that eliminates the need for a traditional decoder, thus significantly simplifying the model’s structure and reducing its computational demands. This architecture enhances both the training efficiency and the performance of direct travel time predictions. With these enhancements, PTE effectively tackles the challenges presented by dynamic traffic patterns, significantly improving prediction performance across multiple time horizons. Comprehensive evaluations on an extensive real-world traffic dataset demonstrate PTE’s superior performance in predicting travel times over multiple horizons compared to existing methods. PTE is notably effective in adapting to high-variability road segments and peak traffic hours. These results prove PTE’s effectiveness and robustness across diverse traffic environments, indicating its significant contribution to advancing traffic prediction capabilities within ITS.
Benchmarking Android Malware Analysis Tools
Authors: Bermejo Higuera Javier , Morales Moreno Javier , Bermejo Higuera Juan Ramón , Sicilia Montalvo Juan Antonio , Barreiro Martillo Gustavo Javier , Sureda Riera Tomas Miguel
Published: May 2024

Today, malware is arguably one of the biggest challenges organisations face from a cybersecurity standpoint, regardless of the types of devices used in the organisation. One of the most malware-attacked mobile operating systems today is Android. In response to this threat, this paper presents research on the functionalities and performance of different malicious Android application package analysis tools, including one that uses machine learning techniques. In addition, it investigates how these tools streamline the detection, classification, and analysis of malicious Android Application Packages (APKs) for Android operating system devices. As a result of the research included in this article, it can be highlighted that the AndroPytool, a tool that uses machine learning (ML) techniques, obtained the best results with an accuracy of 0.986, so it can be affirmed that the tools that use artificial intelligence techniques used in this study are more efficient in terms of detection capacity. On the other hand, of the online tools analysed, Virustotal and Pithus obtained the best results. Based on the above, new approaches can be suggested in the specification, design, and development of new tools that help to analyse, from a cybersecurity point of view, the code of applications developed for this environment.
Porous Flow of Energy and CO2 Transformation and Storage in Deep Formations: An Overview
Authors: Song Rui , Liu Jianjun
Published: May 2024

The transformation and storage of energy and carbon dioxide in deep reservoirs include underground coal gasification, the underground storage of oil and gas, the underground storage of hydrogen, underground compressed air energy storage, the geological utilization and storage of carbon dioxide, etc [...]
Analysis of the Hybrid Power-Heating System in a Single-Family Building, along with Ecological Aspects of the Operation
Authors: Woroniak Grzegorz , Piotrowska-Woroniak Joanna , Woroniak Anna , Owczarek Edyta , Giza Krystyna
Published: May 2024

This study evaluates a hybrid heating system in a single-family building in northeastern Poland, which has a temperate continental climate. The analysis covers two heating seasons in 2021/2022 and 2022/2023. The hybrid heating system includes an air heat pump HPA–08 CS Plus with a heating power of 8.2 kW (AHP), a condensing gas boiler VC146/5–5 with a power of 14 kW (GB–Condens.), and a solid fuel boiler with a power of 11 kW for central heating. Additionally, hot water is heated by a Basic 270 (DHW’s AHP) air–water heat pump with a power of 2 kW, utilizing a tank with a capacity of 270 dm3 equipped with two heating coils. The building’s average electricity consumption is around 5400 kWh/year. A 4.96 kWp photovoltaic installation is installed on the building’s roof at a 40° angle towards the south to supplement the hybrid system. The study aims to assess whether the PV installation can adequately cover the energy needs of the hybrid heat source for heating and hot water. Furthermore, the study calculates the emission of pollutants (CO2, SOx, NOx, CO, and PM10) into the atmosphere. The total annual electricity production from PV installations was 5444.9 kWh in 2021/2022 and 5684.8 kWh in 2022/2023. The excess electricity was stored in the PGE power grid as per the Prosumer settlement rules. The installed PV installation is sufficient to power the following devices annually: AHP, DHW’s AHP, and GB–Condens. However, the daily electricity production from the PV installation is not enough to cover the energy needs of the heat pump for heating during the cold months in Poland (I–III, XI–XII). It can meet the power needs of a PC all year round and can also be stored during the summer months, for example, in energy warehouses or by directly storing it in the PGE power grid. The use of the PV installation resulted in an average reduction in pollutant emissions into the atmosphere: CO2—94.1%, SOx—91.8%, NOx—95.6%, CO—9.7%, and PM10—32.1%.
First Successful Wireline Stress Testing in a Gas Hydrate Reservoir in the Hyuganada Sea, Japan
Authors: Ohtsuki Satoshi , Gao Bei , Yoshii Takanao , Maehara Yuki , Watanabe Daigoro , Kanno Takayuki , Fan Zhaoya
Published: May 2024

This study presents a stress testing operation conducted using a wireline formation tester in a newly discovered gas hydrate prospect located offshore in Japan. The campaign, which spanned from December 2021 to January 2022, involved drilling a well using logging-while-drilling technology. Subsequently, wireline formation testing and stress testing were successfully conducted at three different depths within a gas hydrate-concentrated zone. The testing was accomplished in a single riserless descent, with the primary goal of obtaining crucial data such as mobility, formation pressure, and fracture gradient for one of the prospects. This operation marked the first stress testing job performed with dual packers in an open water and deepwater environment specifically for gas hydrate reservoirs. The study also provides a comprehensive interpretation of the data gathered during the operation. Moreover, it evaluates various properties such as formation mobility, formation pressure, initial breakdown pressure, closure pressure, fracture propagation pressure, and instantaneous shut-in pressure.
Correction: Xia et al. Resveratrol Alleviates Zearalenone-Induced Intestinal Dysfunction in Mice through the NF-κB/Nrf2/HO-1 Signalling Pathway. Foods 2024, 13, 1217
Authors: Xia Sugan , Yan Chaoyue , Gu Jianhong , Yuan Yan , Zou Hui , Liu Zongping , Bian Jianchun
Published: May 2024

In the original publication [...]
High-Oleic Sunflower Oil as a Potential Substitute for Palm Oil in Sugar Coatings—A Comparative Quality Determination Using Multispectral Imaging and an Electronic Nose
Authors: Ollinger Nicole , Blank-Landeshammer Bernhard , Schütz-Kapl Lisa , Rochard Angeline , Pfeifenberger Iris , Carstensen Jens Michael , Müller Manfred , Weghuber Julian
Published: May 2024

Palm oil has a bad reputation due to the exploitation of farmers and the destruction of endangered animal habitats. Therefore, many consumers wish to avoid the use of palm oil. Decorative sugar contains a small amount of palm oil to prevent the sugar from melting on hot bakery products. High-oleic sunflower oil used as a substitute for palm oil was analyzed in this study via multispectral imaging and an electronic nose, two methods suitable for potential large-batch analysis of sugar/oil coatings. Multispectral imaging is a nondestructive method for comparing the wavelength reflections of the surface of a sample. Reference samples enabled the estimation of the quality of unknown samples, which were confirmed via acid value measurements. Additionally, for quality determination, volatile compounds from decorative sugars were measured with an electronic nose. Both applications provide comparable data that provide information about the quality of decorative sugars.
Glyphosate as a Food Contaminant: Main Sources, Detection Levels, and Implications for Human and Public Health
Authors: de Morais Valentim Juliana Maria Bitencourt , Coradi Carolina , Viana Natália Prudêncio , Fagundes Tatiane Renata , Micheletti Pâmela Lonardoni , Gaboardi Shaiane Carla , Fadel Bruna , Pizzatti Luciana , Candiotto Luciano Zanetti Pessoa , Panis Carolina
Published: May 2024

Glyphosate is a broad-spectrum pesticide that has become the most widely used herbicide globally. However, concerns have risen regarding its potential health impacts due to food contamination. Studies have detected glyphosate in human blood and urine samples, indicating human exposure and its persistence in the organism. A growing body of literature has reported the health risks concerning glyphosate exposure, suggesting that the daily intake of contaminated food and water poses a public health concern. Furthermore, countries with high glyphosate usage and lenient regulations regarding food and water contamination may face more severe consequences. In this context, in this review, we examined the literature regarding food contamination by glyphosate, discussed its detection methods, and highlighted its risks to human health.
The Response of the Inner Dark Matter Halo to Stellar Bars
Authors: Marostica Daniel A. , Machado Rubens E. G. , Athanassoula E. , Manos T.
Published: May 2024

Barred galaxies constitute about two-thirds of observed disc galaxies. Bars affect not only the mass distribution of gas and stars but also that of the dark matter. An elongation of the inner dark matter halo is known as the halo bar. We aim to characterize the structure of the halo bars, with the goal of correlating them with the properties of the stellar bars. We use a suite of simulated galaxies with various bar strengths, including gas and star formation. We quantify the strengths, shapes, and densities of these simulated stellar bars. We carry out numerical experiments with frozen and analytic potentials in order to understand the role played by a live responsive stellar bar. We find that the halo bar generally follows the trends of the disc bar. The strengths of the halo and stellar bars are tightly correlated. Stronger bars induce a slight increase in dark matter density within the inner halo. Numerical experiments show that a non-responsive frozen stellar bar would be capable of inducing a dark matter bar, but it would be weaker than the live case by a factor of roughly two.
Improvement of Surimi Gel from Frozen-Stored Silver Carp
Authors: Yang Jingyi , Yu Xiliang , Dong Xiuping , Yu Chenxu
Published: May 2024

Silver Carp (SC) is an under-utilized, invasive species in North American river systems. In this study, the synergistic effects of manufactured Microfiber (MMF), Transglutaminase (TG), and chicken skin collagen (CLG)) to enhance surimi gel quality from frozen SC were studied. The gel strength, textural properties, rheological properties, water-holding capacity (WHC), water mobility, microstructure, and protein composition of the gel samples were determined to assess the impact of the additives individually and synergistically. The results suggested that TG had the most pronounced effect on the surimi gel properties by promoting protein cross-linking. Synergistic effects between TG, MMF, and CLG can bring effective gel property enhancement larger than the individual effect of each additive alone. With the established response-surface models, the combination of CLG and MMF can be optimized to produce surimi gels with less TG but comparable in properties to that of the optimal result with high TG usage. The findings of this study provided a technical foundation for making high-quality surimi gel products out of frozen-stored SC with synergistic utilization of additives, which could serve as guidelines for the industrial development of new surimi products.
The Swelling–Shrinkage Properties of Intact and Disturbed Clayey and Marly Soils: The Density Effect
Authors: Makki Lamis , Duc Myriam , Coppée Thibault , Szymkiewicz Fabien
Published: May 2024

Expansive soils commonly encountered beneath foundations often lead to structural issues inducing expensive repairs. With the increase of the frequency of dry summers and irregular rainfall patterns, the clayey and marly soils become more and more sensitive to shrinking and swelling phenomena. So to find solutions and improve the knowledge on such phenomena especially in temperate countries where the saturation state is considered as the usual soil state, the impact of the soil density on shrinkage was studied by varying the compaction mode and introducing a swelling step before shrinkage. As expected, dynamically or statically compacted clayey or marly soils exhibited high shrinkage deformation when the soil had a low density. The swelling before shrinkage impacted the soil structure but ultimately had a low effect on shrinkage deformation. Swelling deformation was also influenced by density; the denser the soil, the more sensitive the compacted soil became to swelling. Furthermore, compaction modes induced differences in swelling or shrinkage amplitude that couldn’t be explained by microstructural observations. Finally, results demonstrated that intact soil behavior after shrinkage could be extrapolated from swelling–shrinkage tests conducted on remolded soil samples, thus decreasing the cost of field investigations.
Enhancing Health and Empowerment: Assessing the Satisfaction of Underprivileged Rural Women Participating in a Functional Literacy Education Program in Kailali District, Nepal
Authors: Na Joong Seon , Bajgai Johny , Sharma Subham , Dhakal Sarmila , Ahn Dong Won , Doh Young-Ah , Kim Yundeok , Lee Kyu-Jae
Published: May 2024

Women’s empowerment and health literacy are essential for fostering community well-being. Empowering women through education and diverse training plays a crucial role in ensuring their prosperity and overall health. This study investigates the satisfaction and experiences of underprivileged rural mothers participating in a functional literacy education program in the Kailali district, Nepal. We assess participants’ perceptions of program effectiveness, examining training content, facilities, and trainers while exploring menstrual hygiene practices and maternal health awareness. Through convenience sampling, 141 underprivileged women from five rural villages near Tikapur were selected from literacy centers run by Mahima Group. Utilizing structured questionnaires and statistical analyses, including descriptive analyses, Spearman’s rho correlation, and Pearson’s chi-square test, we found that 65.2% of participants expressed high satisfaction levels. Moreover, 96.5% found the program highly effective, with 97.9% reporting improved literacy skills and 96.5% demonstrating increased awareness of menstrual hygiene practices. Additionally, 97.2% agreed that the program enhanced maternal and child health knowledge. Significant correlations were observed among the training course, facilities, trainers, and overall training perception. In line with this, significant associations were found between age groups (p = 0.003) and geographical areas (p = 0.023) with satisfaction levels with the literacy program. These results underscore the satisfaction of participants within the literacy program and its impact on their lives, and advocates for its broader implementation to empower marginalized communities for sustainable development.
Pharmaceutical Care in Primary Healthcare—A Study of Nurses’, Pharmacists’, and Physicians’ Experiences of Interprofessional Collaboration
Authors: Helgesen Ann Karin , Nome Carina Marie , Stenbjerg Julie Kjølhede , Arnesen Marie Helen , Aardalen Tina Reinertsen , Dilles Tinne , Grøndahl Vigdis Abrahamsen
Published: May 2024

Implementation of pharmaceutical care for the benefit of patients and health services has been highlighted worldwide. Interprofessional collaboration between nurses, pharmacists, and physicians may contribute to raising awareness of pharmacological challenges, increasing quality, and minimising errors in pharmaceutical care. This study aimed to investigate how nurses, pharmacists, and physicians experience interprofessional collaboration in pharmaceutical care within community healthcare in Norway. The study had an explorative and descriptive design with a qualitative approach. Individual interviews were conducted with 12 healthcare personnel with key roles in pharmaceutical care within community healthcare services. The data were analysed using systematic text condensation. The results revealed three categories and four subcategories: The category “Professional challenges” contained the subcategories “Blurred responsibilities” and “The importance of trust and continuity”. The category “Organisational barriers” contained the subcategories “Lack of information exchange and suitable communications channels” and “Lack of time and meeting places”. The third category was “Nurses—the important link”. This study reveals challenges to and factors of success in increasing high-quality and safe pharmaceutical care, knowledge that can be used in quality work in the community health services and as input in curriculum development for the three professions.
The Pleural Mesothelioma Cases and Mortality in Portugal in 2014–2020: A Descriptive Study
Authors: Santos Cátia , Sacadura-Leite Ema , Ferreira Joana , Dixe Maria dos Anjos , Astoul Philippe , Sousa-Uva António
Published: May 2024

Background: The incidence and mortality of pleural mesothelioma (PM) reflect the production and consumption of asbestos over time. However, despite the current global concern, these data remain to be known. Objective: Our aim was to carry out a descriptive analysis of PM cases and mortality from some Portuguese databases between 2014 and 2020. Methods: A retrospective observational study was carried out between 2014 and 2020. Data on the number of PM cases were provided by the Portuguese Cancer Registry, and data on mortality were from the Portuguese Death Certificate Information System. Results: Between 2014 and 2020, 315 cases of PM were reported, with 222 (70.5%) men. The average age of patients was 72.1, with the highest number of cases in patients aged >70 years (n = 198; 62.9%). The highest number of cases was reported in 2018 (n = 62; 19.7%). Regarding mortality, 169 deaths were reported, with 126 (74.6%) men and mostly in individuals aged >70 years (n = 109; 64.5%). It is estimated that around 520 years of potential life were lost. The highest number of deaths occurred in 2015 (n = 33; 19.5%). Conclusion: It is mandatory to reinforce the need for surveillance programs that allow us to gather real and reliable data and eliminate asbestos-related diseases.
The Experiences of Young People with Intellectual Disability, Parents and Professionals in Relationships and Sexuality Education Programmes: Findings from a Qualitative Study
Authors: Brown Michael , Linden Mark , Marsh Lynne , Truesdale Maria , Sheerin Fintan , McCormick Freda
Published: May 2024

People with intellectual disability want friendships and meaningful relationships, and some want intimacy. However, the expression of sexuality is an area where potential freedoms are often limited and restricted compared to their peers. While some relationships and sexuality education programmes do exist for this population, most focus on knowledge acquisition regarding sexuality and sex but lack in their focus on relationships, informed choices and decision-making. The aim of this study was to identify good practices and methods of delivery in relationships and sexuality education for children and young people with intellectual disability. A qualitative design was undertaken. Information about our study was distributed to eight special schools in the UK. Semi-structured interviews and focus groups were employed for data collection. Data from 37 pupils with intellectual disability, 11 parents and 16 healthcare and other professionals were thematically analysed. Following data analysis, three themes emerged: (i) seeking and sharing information; (ii) protecting and keeping safe; and (iii) learning for the future. The findings highlight that pupils are keen to learn about life changes and societal influences and want reliable information. Parents and professionals recognise that children and young people with intellectual disability will develop into adults and may be vulnerable when they leave the security of the school setting. They recognise that children and young people need to know about socialising, puberty, consent and contraception. Evidence-based programmes should be designed with these stakeholders to ensure children and young people with intellectual disability receive developmentally appropriate information to make happy and safe decisions about their relationships.
Morphological Clues of Acute Monocytic Leukemia in COVID-19-Induced Transient Leukoerythroblastic Reaction with Monocytosis
Authors: Tam Ingrid S. , Elemary Mohamed , DeCoteau John , Porwit Anna , Torlakovic Emina E.
Published: May 2024

Viral infections, including those caused by COVID-19, can produce striking morphologic changes in peripheral blood. Distinguishing between reactive changes and abnormal morphology of monocytes remains particularly difficult, with low consensus rates reported amongst hematopathologists. Here, we report a patient who developed transient monocytosis of 11.06 × 109/L with 32% promonocytes and 1% blasts during hospitalization that was secondary to severe COVID-19 infection. Three days later, the clinical status of the patient improved and the WBC had decreased to 8.47 × 109/L with 2.2 × 109/L monocytes. Flow cytometry studies did not reveal immunophenotypic findings specific for an overt malignant population. At no time during admission did the patient develop cytopenia(s), and she was discharged upon clinical improvement. However, the peripheral blood sample containing promonocytes was sent for molecular testing with an extended next-generation sequencing myeloid panel and was positive for pathogenic NPM1 Type A and DNMT3A R882H mutations. Subsequently, despite an essentially normal complete blood count, the patient underwent a bone marrow assessment that showed acute myeloid leukemia with 77% promonocytes. This case emphasizes the critical importance of a full work up to exclude acute leukemia when classical promonocyte morphology is encountered in the peripheral blood. Promonocytes are not a part of the reactive changes associated with COVID-19 and remain specific to myeloid neoplasia.
Toxicity of the New Psychoactive Substance (NPS) Clephedrone (4-Chloromethcathinone, 4-CMC): Prediction of Toxicity Using In Silico Methods for Clinical and Forensic Purposes
Authors: Jurowski Kamil , Niżnik Łukasz
Published: May 2024

This study reports the first application of in silico methods to assess the toxicity of 4-chloromethcathinone (4-CMC), a novel psychoactive substance (NPS). Employing advanced toxicology in silico tools, it was possible to predict crucial aspects of the toxicological profile of 4-CMC, including acute toxicity (LD50), genotoxicity, cardiotoxicity, and its potential for endocrine disruption. The obtained results indicate significant acute toxicity with species-specific variability, moderate genotoxic potential suggesting the risk of DNA damage, and a notable cardiotoxicity risk associated with hERG channel inhibition. Endocrine disruption assessment revealed a low probability of 4-CMC interacting with estrogen receptor alpha (ER-α), suggesting minimal estrogenic activity. These insights, derived from in silico studies, are critical in advancing the understanding of 4-CMC properties in forensic and clinical toxicology. These initial toxicological findings provide a foundation for future research and aid in the formulation of risk assessment and management strategies in the context of the use and abuse of NPSs.
An Ecosystem for the Provision of Digital Accessibility for People with Special Needs
Authors: Bogdanova Galina , Todorov Todor , Noev Nikolay , Sabev Negoslav , Chehlarova Neda , Todorova-Ekmekci Mirena , Krastev Aleksandar
Published: May 2024

Digital technologies occupy an important place in today’s developing world. They are also strongly related to new trends in educational technologies. In this context, the digital accessibility of this new environment for people with various special needs is of particular concern. A novel tool for assessment of the technological ecosystem, designed to provide digital accessibility to people with special needs, is described in the paper. The overall structure and the initial test of the system are discussed in the paper. The conceptual framework of the ecosystem and its ontological model are described. Special attention is paid to the accessibility of digital learning and e-learning for people with special needs from a robotic perspective.
Improving Minority Class Recall through a Novel Cluster-Based Oversampling Technique
Authors: Prexawanprasut Takorn , Banditwattanawong Thepparit
Published: May 2024

In this study, we propose an approach to address the pressing issue of false negative errors by enhancing minority class recall within imbalanced data sets commonly encountered in machine learning applications. Through the utilization of a cluster-based oversampling technique in conjunction with an information entropy evaluation, our approach effectively targets areas of ambiguity inherent in the data set. An extensive evaluation across a diverse range of real-world data sets characterized by inter-cluster complexity demonstrates the superior performance of our method compared to that of existing oversampling techniques. Particularly noteworthy is its significant improvement within the Delinquency Telecom data set, where it achieves a remarkable increase of up to 30.54 percent in minority class recall compared to the original data set. This notable reduction in false negative errors underscores the importance of our methodology in accurately identifying and classifying instances from underrepresented classes, thereby enhancing model performance in imbalanced data scenarios.
On-Site Physiotherapy in Emergency Department Patients Presenting with Nonspecific Low Back Pain: A Randomized Controlled Trial
Authors: Chrobok Leon , Espejo Tanguy , Riedel Henk B. , Kirchberger Joris , Overberg Jan-Arie , Felber Florina , Perrot Guido , Nickel Christian H. , Bingisser Roland
Published: May 2024

Background: There is a high incidence of nonspecific Low Back Pain (LBP) in patients visiting Emergency Departments (EDs), but there is a lack of knowledge regarding emergency physiotherapy for LBP. The effect of on-site physiotherapy in these patients was therefore never demonstrated. We assessed short-term outcomes, feasibility and patient satisfaction with physiotherapy in ED patients presenting with nonspecific LBP. Methods: A block-randomized, controlled, open-label trial with a follow-up of 42 days. Patients aged 18 years or older presenting to an ED with nonspecific LBP were prospectively enrolled. Both groups received the same booklet with written information on LBP management and exercises. Patients in the intervention group were given additional instructions by a certified physiotherapist. Results: We included 86 patients in the primary analysis. The median age was 40, and 40.7% were female. At day 7, the median Oswestry Disability Index (ODI) was 2 points lower in the intervention group compared to the control group, which was not statistically significant. There was no between-group difference in pain at day 7. Patients who received physiotherapy felt significantly more confident with the exercises they were taught (p = 0.004, effect size = 0.3 [95% CI 0.1 to 0.5]). Conclusions: On-site physiotherapy in ED patients presenting with nonspecific low back pain is associated with higher patient satisfaction, compared to standard of care. The effect of physiotherapy was small, with only minimal improvement in disability, but without a reduction in pain. Despite the very small effect size, physiotherapeutic interventions should be investigated in larger cohorts with an extended intervention including patient education, exercises, and other physiotherapeutic modalities.