bluuebunny/crossref_metadata_2025 huggingface dataset:
Bone Marrow Mesenchymal Stem Cell Exosomal miR-345-3p Ameliorates Cerebral Ischemia-reperfusion Injury by Targeting TRAF6
Authors: Hou Dan , Zhang Lei , Hu Yujie , Yang Guoshuai , Yu Dan
Published: September 2023

Introduction:

The purpose of this study was to investigate the effects of bone marrow
mesenchymal stem cells (BMSCs) exosomal miR-345-3p and tumor necrosis factor receptorassociated
factor 6 (TRAF6) on cerebral ischemia reperfusion (CIR) injury. Exosomes (Exos) derived
from BMSCs were isolated and identified. PC12 (rat pheochromocytoma) cells were used to
establish an oxygen and glucose deprivation/reoxygenation (OGD/R) model.

Methods:

Cell counting kit-8, TUNEL staining, lactate dehydrogenase staining, RT-qPCR, and
western blotting were utilized for analyzing the functions of miR-345-3p about PC12 cells. Dualluciferase
reporter experiment was then to confirm the link between miR-345-3p and TRAF6. Finally,
using male SD rats, the middle cerebral artery occlusion (MCAO) model was constructed.
Regulation of I/R damage in MCAO rats of miR-345-3p and TRAF6 were further explored in the
changes of modified neurological severity score, cerebral infarction pictures, relative infarct volume,
and histopathological changes. After OGD/R treatment, neuronal apoptosis was dramatically
increased. After treatment with exosomal miR-345-3p, OGD/R-induced neuroapoptosis was dramatically
inhibited. Exosomal miR-345-3p inhibited OGD/R-induced neuroapoptosis by downregulating
the expression of TRAF6. However, the miR-345-3p inhibitor aggravated the changes
caused by OGD/R.

Results:

The corresponding regulations of miR-345-3p were reversed with TRAF6 overexpression.
The animal experiments in vivo further verified that miR-345-3p ameliorated brain I/R injury in
MCAO rats by targeting TRAF6.

Conclusion:

This study found that BMSCs-exosomal miR-345-3p protected against CIR injury by
decreasing TRAF6.
The Effect of Aloe vera on the Healing of Diabetic Foot Ulcer: A Randomized,
Double-blind Clinical Trial
Authors: Irani Parichehr Sabaghzadeh , Ranjbar Hadi , Mehdipour-Rabori Roghayeh , Torkaman Mahya , Amirsalari Sudabeh , Alazmani-Noodeh Farshid
Published: September 2023

Background:

Diabetic foot ulcer (DFU) is a prevalent complication of diabetes that can result
in severe consequences. The cost of treating DFUs is high, and there is a lack of new therapies
available in developing countries. This has created a demand for complementary and alternative
treatments. The objective of this study was to assess the impact of aloe vera gel on the healing process
of diabetic foot ulcers.

Methods and Materials:

The study was a double-blind, randomized, controlled clinical trial. The
study samples were 66 patients with diabetic foot ulcers who were randomly assigned to two groups
(intervention and control). All ulcers in both groups were washed with normal saline and dressed in
sterile gauze. The ulcers in the intervention group were covered with a thin layer of Aloe Vera gel before
the dressing. The Bates-Jensen Wound Assessment Tool (BWAT) was used on three occasions,
including before the intervention period and at the end of each week. Data were analyzed using SPSS
16.

Results:

After three weeks, there was a notable contrast in the recovery pattern of the two groups. The
patients who had aloe vera gel added to their dressing showed a more substantial decrease in the mean
scores of their BWAT.

Conclusion:

These findings are promising and suggest that Aloe vera may be a safe and effective adjunctive
treatment for diabetic foot ulcers. However, further research is needed to confirm these results
and to investigate the underlying mechanisms of aloe vera's therapeutic effect on diabetic foot ulcers.
Design, Synthesis, QSAR Studies, and Molecular Modeling of Some Novel
Bis Methyl 2-[3-(benzo[d]thiazol-2-yl)-2-terephthaloyl-bis-4-oxo-thiazolidin-
5-ylidene]acetates and Screening of their Antioxidant and Enzyme Inhibition Properties
Authors: Naseem Muhammad , Rafique Hummera , Tayyab Muhammad , Saeed Aamer , Mumtaz Amara
Published: September 2023

Introduction:

Benzothiazolamine-based bisthiourea precursors were prepared in good yields. These bisthiourea derivatives were cyclized into symmetrical Bis Methyl 2-[3-(benzothia-zol-2-yl)-2-terephthaloyl-bis-4-oxo-thiazolidin-5-ylidene]acetates, by their condensation with (DMAD) dimethyl but-2-meditate in the presence of dry methanol.

Materials and Methods:

All these compounds were evaluated for their biological applications. An-tioxidant activities were performed by adopting a DPPH radical assay, and an in vitro enzyme in-hibition assay was performed to investigate their enzyme inhibitory potential against butyrylcholin-esterase (BChE) and acetylcholinesterase (AChE).

Results:

Molecular modeling and QSAR studies were performed to monitor the binding propensity of imidathiazolidinone derivatives with enzymes and DNA. Also, electronic and steric descriptors were calculated to determine the effect of structure on the activity of imidathiazolidinone deriva-tives.

Conclusion:

The characterization of all the synthesized compounds was done by their physical data, FT-IR, NMR and elemental analysis.
The Role of MRI in Diagnosing Agenesis of the Corpus Callosum (ACC): A
Rare Disorder Present at Birth
Authors: Alkurim Alhassan , Alyami Jaber , Aldusary Njoud , Alahmadi Adnan
Published: September 2023

Background:

Agenesis of the corpus callosum (ACC) is a rare hereditary nervous system defect present at birth. ACC is an uncommon condition that is unrepresentative in the general population because some cases do not present with any identifiable symptoms in the early stage.

Case Report:

We present a case of ACC in a two-month-old male patient who was diagnosed after birth. Although the initial brain ultrasound (US) showed dilation of the lateral ventricles and the absence of the corpus callosum, these findings were not fully confirmed. Therefore, magnetic resonance imaging (MRI) of the brain was conducted to confirm the complex diagnosis, and the examination revealed complete ACC. Diagnosing ACC in a neonate demonstrates the complexity of diagnosis through the clinical presentation, especially at an early age.

Conclusion:

The clinical utility of neonatal US and MRI highlights the importance of an early diagnosis of ACC. MRI is more effective than the US in detecting this condition, and these imaging modalities provide the patient with an early diagnosis, which helps in treatment management.
Interactions Between Antimicrobial Peptides and Targets Responsible for
their Nephrotoxic Action: Molecular Dynamics Simulations
Authors: Lisnyak Yury , Martynov Artur , Farber Boris
Published: September 2023

Objectives:

Polymyxin is the last line of defense against resistant forms of microorganisms,
but it has significant nephrotoxicity. One of the directions in reducing the nephrotoxicity of
polymyxin is to modify the charge of the molecule and accordingly, to change the topicity of the
polymyxin derivative to the renal megalin. Such modification can lead to a decrease in the accumulation
of polymyxin in the kidneys and reduce its toxicity while maintaining its antimicrobial properties.
The study aimed to investigate the structural aspects of polymyxin nephrotoxicity at the
atomic level to promote the more purposeful development of the polymyxin’s derivatives with the
lower nephrotoxic action.

Materials and methods:

The molecular dynamics simulations of the complexes of polymyxin B
and its derivative NAB7061 (that carries only three positive charges located within the
macrocycle) with megalin were performed in program package YASARA structure with explicit
water (TIP3P) and ions (0.9 % NaCl) in NPT ensemble using the AMRER03 force field. After 10
ns equilibration, each system was simulated at 298 K and pH 7.4 for a 25 ns production phase.
Simulations were run twice for each molecular system.

Results:

By molecular dynamics simulations, the possibility was shown for polymyxin to form a
stable complex with two neighbor structural domains of megalin in accord with the universal
mechanism of binding the cationic ligands by ligand-binding CR repeats of the LDLR-family
receptors. It was reported that interactions of megalin with polymyxin were stronger than with its
derivative having no positively charged groups outside the macrocycle. The structural prerequisites
of these differences were revealed, explaining the less nephrotoxicity of such derivatives compared
to polymyxin.

Conclusion:

Comparative molecular dynamics simulations of megalin interactions with polymyxin
B and its derivative NAB7061, which carries no positive charges outside the macrocycle, revealed
the possible structural prerequisites for the lower nephrotoxic action of such polymyxin derivatives.
The weakening of polymyxins binding with megalin may become an effective preventive
measure against polymyxin-induced nephrotoxicity.
Synthesis of Cu-doped ZnO Nanoparticles Using Aloe vera Leaf Extract for Antibacterial and Photocatalytic Activities Evaluation
Authors: Degefa Mulatu , Muleta Guta , Teshome Kirubel
Published: September 2023

Background:

Fabrication of nanoparticles (NPs) by the biological approach has gained extensive
attention recently due to its low cost, simplicity, non-toxic and environmentally-friendly nature,
as compared to the toxic as well as expensive chemical and physical methods. This study aimed
to synthesize ZnO and Cu-doped ZnO NPs using Aloe vera leaf extract for their photocatalytic and antibacterial
activities evaluation.

Methods:

ZnO and Cu-doped ZnO NPs were synthesized using Aloe vera extract by optimizing the
reaction parameters, including precursor salt concentration, plant extract volume, and solution pH. The
as-synthesized nanoproducts were characterized using FT-IR, UV-Vis, SEM, and XRD spectroscopic
techniques, and tested as antibacterial agents and photocatalysts.

Results:

The XRD pattern data indicated all the synthesized NPs to have a crystallite nature with a
particle size of 19.24 nm, 23.74 nm, and 24.91 nm for ZnO, 1% Cu-doped ZnO, and 4% Cu-doped
ZnO NPs, respectively. SEM image revealed crushed-ice, irregular, and spherical shapes of the NPs.
The synthesized nanoproducts displayed good antibacterial activity, and the best potential was observed
against gram-positive bacteria (B. cereus and S. aureus) of 4% Cu-doped ZnO NPs, followed
by 1% Cu-doped ZnO NPs, with the reference to the selected standards gentamicin and DMSO, while
the least inhibition zone was seen against gram-negative bacteria (E. coli and S. typhi). 1% Cu-doped
ZnO and 4% Cu-doped ZnO NPs displayed good photocatalytic potential at 78.48% and 88.07%, respectively,
after 180 min of irradiation, while 4% Cu-doped ZnO NPs displayed better degrading potential
with effective reusability.

Conclusion:

The good antibacterial and photocatalytic activities of the synthesized Cu-doped ZnO
NPs may lead to the application of the nanomaterials in antimicrobial and catalysis fields with the required
modifications for enhancement of their potential.
Developing and implementing an instrument for assessing critical thinking and visual representations in learning Physics materials of Optical Instruments
Authors: Nurulhasni Dewi , Nurbaiti Eka Ayu , Nabila Rosa Safirotun , Jumadi Jumadi
Published: September 2023

This study aims to develop an assessment instrument to measure students' critical thinking and visual representation abilities in optical instrument material. This research and development (RD) employed the ADDIE (Analysis, Design, Development, Implementation, and Evaluation) instructional model. This research develops a test instrument that has more specific stages so the ADDIE development stage is integrated with the development stage of the test instrument developed by Mardapi. The subjects in this study are grade XI students of State Madrasah Aliyah (MAN) 4 Bantul. This study produced a test instrument for measuring students' critical thinking and visual representation abilities, with high validity,and analyzed using Aiken's V. The items for assessing critical thinking and visual representation abilities were analyzed using the QUEST program with the following findings. (1) The analysis results of instrument validation using Aiken's V obtained an average Aiken's Value above 0.4 with high validity and moderate validity criteria so all items are valid. (2) The pre-test analysis on item estimates obtained MNSQ Infit in the range 0.77-1.30 and the value of outfit t ≤ 2 and in the MNSQ Infit case estimates in the range 0.77-1.30, so overall, the items matched to Rasch models. (3) Post-test analysis on item estimates obtained MNSQ Infit in the range 0.77-1.30 and outfit t value ≤ 2 and in case estimates MNSQ Infit in the range 0.77-1.30 so, overall, items are in accordance with Rasch models. (4) The reliability of the pre-test items is 0.92 while the reliability of the post-test items is 0.76. (5) The difficulty level of the items in the pre-test results shows that Question 10 is the most difficult while number 3 is the easiest, and in the post-test results, Question 8 is the most difficult while Question 6 is the easiest.
The Use of Patient-Oriented Mobile Phone Apps in Oral Health: Scoping Review (Preprint)
Authors: Väyrynen Elina , Hakola Sanna , Keski-Salmi Anniina , Jämsä Hannaleena , Vainionpää Raija , Karki Saujanya
Published: September 2023

BACKGROUND

Oral health is a significant part of general health. Poor oral health can influence an individual’s appearance, self-esteem, eating, and speaking. The use of mobile phone apps has been growing in the field of medicine, including dentistry. However, to date, there is no evidence related to the availability of mobile apps focusing on various branches of dentistry.

OBJECTIVE

The aim of this study was to review the scientific literature on the use of patient-oriented mobile phone apps in oral health and summarize the key findings.

METHODS

A scoping review of published scientific literature on the use of patient-oriented mobile phone apps in oral health was conducted in accordance with the Joanna Briggs Institute. A search was performed in PubMed and Scopus for studies published between January 2000 and June 2021 that were written in English. All study types except for those reporting developmental protocols were included in this review. In total, 2 reviewers independently screened the studies using the eligibility criteria. The study protocol was registered in the Open Science Framework registries in June 2021.

RESULTS

The initial search yielded a total of 977 studies, 45 (4.6%) of which met the inclusion criteria. All the studies (45/45, 100%) were published after 2009. Most studies (31/45, 69%) concerned oral health promotion using mobile phone apps, followed by behavior management (5/45, 11%). More than half (23/45, 51%) of the included studies were conducted in Asian countries. Overall, 31% (14/45) of the studies focused on adolescents. A total of 51% (23/45) of the studies were randomized controlled trials (RCTs). Approximately 39% (9/23) of the included RCT studies reported a substantial reduction in dental plaque, and 26% (6/23) of the studies reported significant improvement in gingival health. Regarding dental anxiety management, 13% (3/23) of the RCT studies reported a significant decrease in mean heart rate and lower Facial Image Scale scores.

CONCLUSIONS

According to the literature, the use of mobile apps in oral health is increasing among patients, mainly children and adolescents. Many studies that have used mobile apps have focused on promoting oral health. However, other areas such as diagnostic and remote consultations (teledentistry) have until recently been neglected despite their great potential.
Direct-to-Patient Mobile Teledermoscopy: Prospective Observational Study (Preprint)
Authors: Fan Winnie , Mattson Gunnar , Twigg Amanda
Published: September 2023

UNSTRUCTURED

Direct-to-patient mobile teledermoscopy is a feasible and useful adjunct to smartphone imaging for monitoring patient-identified lesions of concern, achieving comparable diagnostic and management accuracy as in-office dermatology.
Exploring the Mental Health Characteristics of AI-Based Symptom Checker Users: A Comparison with the Global Burden of Disease Study (Preprint)
Authors: Freyer Oscar , Bergey François , Cotte Fabienne , Gilbert Stephen , Mehl Alicia
Published: September 2023

BACKGROUND

Mental health conditions pose a significant challenge for healthcare systems globally, and digital solutions have been proposed to address the challenges of limited access to healthcare, stigmatization, and lack of reliable data. An understanding of potential risk factors, comorbidities, and symptom constellations forms a necessary foundation for future digital solutions with diagnostic capabilities. Currently used digital products such as symptom checkers generate novel data sets that could provide insight into these correlations, helping both patients and healthcare providers.

OBJECTIVE

This study aimed to compare the characteristics of SC (Ada) users with a suggested mental health condition (MHC) in their symptom assessment (1) to all Ada users and (2) to the general population using the Global Burden of Diseases, Injuries, and Risk Factors (GBD) study 2019 dataset.

METHODS

Aggregated data from the SC was analyzed to provide a descriptive analysis of its users and compared to the World Population Prospects 2019 and the Global Burden of Disease study, which includes estimations for 195 countries and territories. Ada users worldwide who completed a symptom assessment between in 2020 or 2021 were included in the analysis. The study focused on user demographics, reported symptoms, and suggested conditions.

RESULTS

Out of 2,208,700 users, 20.9% received at least one MHC as the top suggestion. Female users (65.0%) were overrepresented in Ada's user base, and the largest number of users were aged 16-24 (57.0%). The average number of symptoms by users confirmed during the question flow was 6.7, with 1.9 symptoms entered initially. Major depressive disorder was the most frequently suggested MHC, affecting 10.2% of all Ada users, followed by other anxiety disorders (5.7%). Comparison of the Ada dataset with the GBD dataset showed that Depressive disorders and Anxiety disorders were the two most frequent MHCs in both datasets, with females more commonly affected than males.

CONCLUSIONS

Young and female users are overrepresented in the Ada userbase, especially among those with MHC suggestions compared with the GBD dataset. Ada's ability to reach these at-risk populations presents a significant opportunity for providing personalized and accessible healthcare solutions in the future. While the results cannot be easily generalized due to this population bias, this analysis highlights the potential of patient-reported data generated by symptom checkers as a source for epidemiological studies.
Comparación de hipervínculos en tres idiomas de sistemas urbanos de Google en cuatro países latinoamericanos
Authors: Hernández-Lara Óscar Gerardo , Brunn Stanley D.
Published: September 2023

Se utilizaron hipervínculos de Google Scholar para medir el posicionamiento de algunos centros urbanos de Argentina, Brasil, Chile y México. Los volúmenes de hipervínculos se comparan en español, portugués e inglés para discernir diferencias con respecto al idioma de búsqueda. Surgen dos hallazgos: primero, que cada país tiene una ciudad dominante, a la que la mayoría de las demás en el país están vinculadas; segundo, que hay ciudades claramente centrales, semiperiféricas y periféricas. Esta investigación sienta bases para exploraciones sobre las economías de conocimiento y de la información en éstos y otros países.
Effect of Aerobic Exercise Intervention on Renal Insulin Signaling Pathway in db/db Mice
Authors: Liu Qingyi
Published: September 2023

Objective: To study the effects on insulin signaling pathway in db/db mice during aerobic exercise and discuss the related mechanisms. Methods: Ten BKS mice were selected as the quiet control group (WT group), and 20 BKS-db/db mice were randomly divided into two groups as the diabetic quiet control group (C group) and the diabetic simple exercise group (E group), with 10 mice in each group. The mice in E group were acclimatized to the low-intensity criterion (2~7m/min, 10min/day, 5 days/week) for one week, and then subjected to 8 weeks of aerobic endurance exercise training on a running platform (0° incline, 7~12m/min, 30~40min/day, 5 days/week), while the mice in groups WT and C were kept quietly. At the end of the experiment, the fasting blood glucose content, glucose tolerance, insulin tolerance of each group of mice were detected respectively, and the expression levels of AKT protein and insulin receptor protein were detected by Western Blot technique. Results: (1) Compared with the diabetic quiet control group (Group C), the glucose tolerance and insulin tolerance in the quiet control group (Group WT) showed significant changes (P＜0.05); in the diabetic simple exercise group (Group E), there was no significant change in glucose tolerance and insulin tolerance (P＞0.05). (2) Compared with the diabetic quiet control group (Group C), the expression level of insulin receptor protein was down-regulated (P<0.05) and AKT protein expression was up-regulated (P<0.05) in the diabetic simple exercise group (Group E); compared with the quiet control group (Group WT), the expression level of insulin receptor protein was increased (P<0.05) and AKT protein was decreased (P<0.05) in the diabetic quiet control group (Group C), expression level decreased (P<0.05). Conclusion: Exercise alone could not improve insulin resistance in db/db mice; eight weeks of aerobic exercise improved and corrected renal insulin signaling pathway and alleviated renal insulin resistance in db/db mice.
Decoding ‘Daarosh’: Resisting a Regressive Custom Suppressing Women’s Voice and Violating Her Right
Authors: Singha Abhyudita Gautam
Published: September 2023

This Paper is an attempt to decode the tribal custom prevalent in Himachal Pradesh called Darosh which means forcible marriage where the boy kidnaps the girl of his choice without her consent and establishes a physical relationship with her during that night after which the relationship is formally accepted and recognised as a marriage. This has been depicted in the story called Darosh authored by SR Harnot. The story revolves around the sister of the victim of this ritual who also resists all attempts on her kidnapping. The story gives a glimpse into the custom, delving into the complexities and the hidden circuits of mutual cooperation among the families of the groom and bride and exposes the hypocrisy of society in accepting such marriages that directly encroach on the girl’s right to choose a life partner. It also depicts the strong resistance that the patriarchal system faces from the modern educated women of today.
Generative AI for medical imaging analysis and applications
Authors: Musalamadugu Tanmai Sree , Kannan Hemachandran
Published: September 2023

Generative AI plays a pivotal role in medical imaging analysis, enabling precise diagnosis, treatment planning and disease monitoring. Techniques like generative adversarial networks (GANs) and variational autoencoders (VAEs) enhance medical imaging by generating synthetic images, improving reconstruction, segmentation and facilitating disease diagnosis and treatment planning. Nonetheless, ethical, legal and regulatory concerns arise regarding patient privacy, data protection and fairness. This paper offers an overview of generative AI in medical imaging analysis, highlighting applications, challenges and case studies. It compares results with traditional methods and examines potential implications on healthcare policies. The paper concludes with recommendations for responsible implementation and suggests future research and development directions.
ИЗГОТОВЛЕНИЕ ЛАЗЕРНЫХ МИШЕНЕЙ МЕТОДАМИ ВАКУУМНОГО НАНЕСЕНИЯ ПОКРЫТИЙ
Authors: Арефьев А.И. , Горнов В.Н. , Пешкичева Л.Е. , Юрченко О.С. , Гусс Л.Е. , Савельев А.В. , Котов А.П.
Published: September 2023

В статье представлены результаты отработки технологии изготовления многослойных
тонкопленочных лазерных мишеней. Приведены результаты исследования как исходных материалов, использованных для изготовления мишеней, так и полученных образцов тонких пленок.
Подходы к определению Pseudomonas aeruginosa в воде в национальной и международной нормативно-­методической базе
Authors: Тымчук С.Н. , Спиридонова Е.Ю. , Бугаевская Л.В.
Published: September 2023

Рассмотрены методики, применяемые для обнаружения и идентификации Рseudomonas aeruginosa (синегнойная палочка) в различных водах. Проведено сравнение основных характеристик методик, приведены их недостатки и преимущества. Обращено внимание на противоречивые требования, установленные в разных методиках, низкую чувствительность методик, не предусматривающих концентрирование пробы, и необходимость применения устаревших процедур анализа, а также питательных сред с низкими ростовыми и дифференцирующими свой­ствами. На примере методик определения P. aeruginosa в воде показано, что отечественная методическая база по санитарному контролю качества вод, в том числе на соответствие требованиям к упакованной воде (ТР ЕАЭС 044 / 2018), нуждается в модернизации с учетом международного опыта в данной области.
Percepción de los impuestos en México durante el primer año de la Cuarta Transformación
Authors: Zapata Celestino Kevin
Published: September 2023

La siguiente investigación tiene por objetivo conocer la percepción ciudadana acerca de los impuestos durante el primer año de gobierno de Andrés Manuel López Obrador (AMLO). A través de una metodología cualitativa de grupos de enfoque se hizo una exploración de actitudes acerca de sus responsabilidades fiscales. Los hallazgos obtenidos sugieren que los ciudadanos mantienen una perspectiva negativa de los impuestos, producto de los escándalos de corrupción y las expectativas incumplidas de sus gobernantes. La información señala que los mexicanos han construido una dualidad “nosotros-ellos” dentro del imaginario colectivo, para diferenciarse de los políticos y empresarios, y esto impacta de forma negativa en su disposición para pagar sus contribuciones. Los grupos focales demostraron que la credibilidad del presidente Andrés Manuel López Obrador, era una variable que ponía en contradicción las actitudes iniciales de los participantes. Lo anterior parece indicar que la “autoridad moral” del presidente influye directamente en la opinión pública, al grado que las percepciones negativas de los impuestos se revierten, aunque no exentas de escepticismo.
Categorías, narrativas y órdenes jerárquicos: apuntes para el estudio de los procesos de jerarquización
Authors: Gessaghi Victoria , Landau Matías , Luci Florencia
Published: September 2023

Este artículo realiza un aporte conceptual de reflexión sobre procesos de jerarquización en las sociedades contemporáneas. A partir de ciertos estudios sociológicos y antropológicos que permiten pensar la noción de jerarquía, el artículo desarrolla tres conceptos clave para el estudio de los procesos de jerarquización: 1) categorías jerarquizadas: analiza la relación entre los procesos cognitivos y epistemológicos que, en términos sociales, subyacen a toda forma de clasificación y categorización que ubica a individuos y grupos en posiciones de superioridad y subalternidad; 2) narrativa jerárquica: en tanto trama discursiva da sentido, organiza y justifica un determinado estado de las relaciones en las que seres y objetos se vinculan desigualmente en un espacio social estratificado; y 3) orden jerárquico: enfatiza la dimensión práctica, basada en disputas presentes y en diversas formas de sedimentación e institucionalización de relaciones pasadas, de configuración de posiciones relativamente estables.
La ruta de la polarización argentina. Cuatro acontecimientos de los gobiernos de Cristina Fernández de Kirchner (2007-2015)
Authors: Castrelo Víctor
Published: September 2023

En este artículo se busca dar cuenta del proceso de polarización política y social ocurrido en Argentina durante los dos gobiernos de Cristina Fernández de Kirchner (2007-2011/2011-2015), para ello nos centramos en el análisis de cuatro acontecimientos clave: 1) el conflicto con el campo, 2) la sanción de Ley de Servicios de Comunicación Audiovisual, 3) los festejos del bicentenario y 4) las elecciones de 2015. Nuestro objetivo es explicar cuáles fueron los actores que tuvieron un papel destacado en el desarrollo de cada acontecimiento, qué posición sostuvo el gobierno, el tono y el sesgo que adquirió la cobertura por parte de la prensa opositora, cuáles fueron las consecuencias que dejaron en cada involucrado, y de qué manera cada uno de estos hechos fue agregando demandas, tópicos y significantes que contribuyeron a aglutinar a una masa social opositora a las políticas oficialistas. Para abordar estos hechos sociales partimos de la categoría de acontecimiento político, es decir, la acción política en la que quedan evidenciadas las disputas por la fijación de sentidos o, contrariamente, el intento de subvertir aquellos que están institucionalizados.
Fundamentos explicativos de la obstrucción de la democracia en el África postindependentista
Authors: Mballa Louis Valentin
Published: September 2023

Este artículo tiene el objetivo de dar cuenta cómo la obstrucción de la democracia en África postindependentista es resultado de una tensión entre poderes disímiles: el colonizador y el colonizado. En realidad, las dificultades de democratización en esta región se deben principalmente a que, la transición del Estado precolonial al Estado poscolonial, no fue acompañada por cambios estructurales e ideológicos capaces de establecer un orden sociopolítico y económico adecuado a las sociedades africanas; lo cual ha dinamitado los intentos de implementación de las libertades ciudadanas a través de la democracia. Con un método de análisis cualitativo, concluimos que la implementación y consolidación de la democracia en África exige una profunda reingeniería de las estructuras sociopolíticas y económicas, las constituciones, las instituciones, las leyes electorales, los partidos políticos, los parlamentos, los gobiernos y los sistemas jurisdiccionales.
La voz ajena en los titulares periodísticos: una mirada desde la lingüística a sus problemas conceptuales y operacionales
Authors: Silva Meaney Deni Alejandra
Published: September 2023

Nadal Palazón, Juan (2022) Problemas conceptuales y operacionales de los titulares periodísticos: el periodismo de declaraciones. Ciudad de México: Instituto de Investigaciones Filológicas, UNAM.
Online Training for Primary Care Staff: Skills Development on the Mental Health Gap Action Programme (mhGAP) Intervention Guide
Authors: Félix Romero Violeta , Tovar Ángel Eugenio , López-Montoya Alejandra , Flores-Coronado Marco Antonio , Ferrer-Reyes Sandra Ivonne , Morales Chainé Silvia , Malo-Serrano Miguel
Published: September 2023

Developing effective learning strategies to strengthen mental health professionals’ capacities and deliver evidence-based interventions in their communities is urgent. We developed and evaluated an online training program for the Intervention Guide for Mental, Neurological and Substance Use Disorders in Non-specialized Health Settings. Nine hundred and seventy-five health professionals in Mexico were enrolled in the training program, during the period of social distancing brought about by the COVID-19 pandemic. Participants completed a pre-post online evaluation strategy including Knowledge screening, assessment of Learning Activities, and performance in Programmed-Simulated cases to evaluate knowledge and skills for the assessment, management, and follow-up of Mental, Neurological and Substance Use Disorders. We found that participants improved their knowledge and skills from training on the mhGAP online course. Notably we observed these positive results regardless of sex, profession, institution, or social vulnerability rating of participants, suggesting that this is a relevant training program for primary care staff. These results contribute to the Mental Health Gap Action Programme and advance the use of online teaching and evaluation technologies in this field.
DERSR-B. A Brief Scale for Detection of Emotional Dysregulation Risk
Authors: Gómez-Peresmitré Gilda , Platas-Acevedo Romana Silvia
Published: September 2023

Emotional dysregulation (ED) is related to problems in understanding, perceiving, and regulating emotions. The aim is to find the psychometric properties of an instrument that measures ED and classifies the high/low ED group membership with the least possible error. For statistical purposes (factor analysis), two independent samples of males and females (n1 = 476) and (n2 = 562) were obtained, with ages sample 1 (15 -19 years; M= 15.8; SD=0.71) and sample 2 (15-19 years; M=15.6; SD= 0.69). Three factors were formed by sex, males with 14 items and females with 13 items, each loading on a single factor (total α=0.71 - 0.78 ɷ =0.67- 0.79 females; α= 0.70 - 0.79 ɷ=0.73 - 0.75 males) and good fit indices. In sum, a validated cut version instrument (DERSR-B), a risk screening instrument, was obtained.
Impacto de las Creencias Conspirativas en la Intención de Vacunación contra el COVID-19 en Adultos Mexicanos
Authors: Villanueva Bustamante Marcoantonio , Schleef Bustamante Jorge , Padilla Bautista Joaquín Alberto
Published: September 2023

Pese a los esfuerzos de las autoridades sanitarias, la presencia de información falsa o poco certera ha provocado que un porcentaje de la población mexicana se encuentra reticente a recibir la vacuna contra el COVID-19. De este modo el objetivo del presente estudio es determinar en adultos mexicanos el rol mediador de las creencias negativas sobre la vacuna y la percepción de riesgo en la relación de las creencias conspirativas y la intención de vacunación contra el COVID-19. Se realizó un estudio transversal en el que se aplicaron las escalas mediante una plataforma en línea. Las hipótesis fueron probadas mediante la técnica multivariada de análisis de senderos. Los resultados indican que las creencias conspirativas predijeron directamente menor intención de vacunación, asimismo, esta relación se encuentra parcialmente mediada por las creencias negativas sobre la vacuna y la percepción de riesgo. Los hallazgos sugieren que la adhesión a creencias conspirativas sobre el origen del COVID-19 favorecen el desarrollo de temor a los efectos secundarios de la vacuna y la reducción de la percepción de riesgo, convirtiéndose así, en la principal barrera de la intención de vacunación contra el COVID-19.
ATERRO MUNICIPAL DE RESÍDUOS SÓLIDOS DE CARUARU: UM CASO DE ESTUDO SOBRE RETENÇÃO DE GASES NA CAMADA DE COBERTURA
Authors: Santos Glauber Galdino , Bello Maria Isabela Marques da Cunha Vieira , Mariano Maria Odete Holanda , Lins Eduardo Antônio Maia
Published: September 2023

As camadas de cobertura nos aterros sanitários são responsáveis por isolar os resíduos, impedir a entrada de água no maciço, e evitar que os gases gerados no processo de biodegradação da matéria orgânica cheguem até a atmosfera. Este artigo apresenta a avaliação da retenção de gás na camada de cobertura do aterro sanitário da cidade de Caruaru, localizada no nordeste do Brasil. As atividades deste aterro foram encerradas em março de 2018. A avaliação da camada de cobertura se deu por uma caracterização geotécnica do solo (classificação, granulometria, grau de compactação, umidade, grau de saturação, índice de vazios e espessura da camada). Em campo foram realizados 20 ensaios com uma placa de fluxo estática para verificar a quantidade de gás que chegava até a superfície através da camada de cobertura. Os ensaios foram realizados em 4 baterias, em 5 pontos diferentes selecionados de acordo com a idade do resíduo ali disposto (2, 4, 6, 8 e 10 anos, respectivamente). Devido às baixas emissões encontradas nos ensaios de placa foi também investigada a geração de gases no interior da massa de lixo através de 20 ensaios de pressão e concentração com o auxílio do Dispositivo de Medição de Pressão e Concentração (DMPC) e analisadas as emissões de gases em 9 drenos que ficavam próximos aos pontos dos demais ensaios de campo. Segundo a análise granulométrica do material, 4 das amostras retiradas em campo eram formadas por materiais arenosos, sendo: areias siltosas, areia argilosa e areia bem graduada e 1 amostra apresentou uma argila arenosa. Os índices de vazios ficaram entre 0.5 e 0.63, os graus de saturação entre 64.4% e 90.6%, os teores de umidade entre 17% e 20,3% e os graus de compactação entre 80% e 90%...
AVALIAÇÃO DO DESEMPENHO DE UMA ESTAÇÃO DE TRATAMENTO DE ÁGUA DE CICLO COMPLETO LOCALIZADA NO MUNICÍPIO DE MARINGÁ-PR
Authors: Toledo Camila Hamano , Benatti Cláudia Telles
Published: September 2023

As estações de tratamento de água (ETA’s) de ciclo completo realizam a potabilização das águas naturais por meio das etapas de coagulação, floculação, decantação, filtração, desinfecção, fluoretação e correção de pH. Para que haja a garantia do provimento de água tratada com boa qualidade, é necessário que seja avaliado o desempenho das etapas de tratamento de modo a assegurar a eficiência de cada uma delas. Pensando nisso, o presente trabalho visa avaliar o desempenho de uma ETA localizada no interior do Paraná por meio de indicadores fundamentados na qualidade da água bruta, coagulada, decantada, filtrada e tratada, nas características construtivas e operacionais das unidades de tratamento constituintes da ETA e no atendimento à norma técnica NBR 12216/92, às legislações Resolução CONAMA nº 357/5 e Portaria nº 888/21 e às considerações/recomendações realizadas pela literatura. Apesar da qualidade da água bruta mostrar-se comprometida, verificou-se que a qualidade da água tratada se encontra em conformidade com o padrão de potabilidade estabelecido pela Portaria nº888/21. Foram identificados, entretanto, aspectos construtivos e operacionais da ETA a serem melhorados. Devido a isso, o presente trabalho apresenta subsídios que visam melhorar a eficiência da ETA e possibilitar a sustentabilidade do seu sistema de tratamento de água.
AQUAPONICS IN BRAZIL: REVIEW AND SURVEY ON WASTE MANAGEMENT PRACTICES
Authors: Bizon Larissa , Castro Marco Aurélio Soares de
Published: September 2023

Aquaponics is a food production technique that may be applied in the context of urban agriculture to help achieve food security and promote sustainable agriculture and production patterns, among other Sustainable Development Goals. Brazilian population is large and highly concentrated in urban areas and might benefit from this technique. Similar to any other production activity, aquaponic systems generate wastes that must be properly managed, but until now no study focused on waste generated on such systems or on management practices adopted by Brazilian producers; the goal of this article was to address both of these gaps. A systematic review identified waste streams generated on aquaponics, while management practices were seldom mentioned and addressed. A survey on producers located in 17 of the 27 Brazilian federal units helped confirm sludge, packaging waste, dead fish and unusable plant fractions as typical waste streams. It also identified a lack of concern for a more in-depth assessment of such streams to improve management practices, which tended to gravitate toward adequate and inadequate disposal. Finally, the article proposes management practices for each waste stream, drawing from strategies foreseen in Brazilian National Solid Waste Policy.
REMOÇÃO DE CO2 DE BIOGÁS DE ATERRO SANITÁRIO EMPREGANDO COLUNA DE ABSORÇÃO COM SOLUÇÃO ALCALINA
Authors: Pedroza Marcelo Mendes , Rios Rui Felipe de Miranda , Arruda Matheus Gomes , Rezende Cláudia da Silva Aguiar Rezende , Soares João Evangelista Marques
Published: September 2023

Essa pesquisa teve como objetivo avaliar a remoção de CO2 do biogás oriundo do Aterro Sanitário de resíduos sólidos urbanos da cidade de Palmas - Tocantins, empregando um sistema lavador de gases de baixo custo com adição de aditivos na água de lavagem, submetidos a variações construtivas e operacionais. A medição de fluxo (semanal e perfil diário) do biogás foi realizada através de um dreno vertical localizado em uma das células do Aterro Sanitário. Foi empregado um medidor de gás GLP Predial para medir a vazão do biocombustível. Os testes de purificação do biogás foram realizados através de um lavador de gases, sendo empregado soluções de hidróxido de cálcio para a retirada do CO2. Foi avaliada a variável concentração da solução alcalina durante os testes de purificação de biogás. As amostras foram coletadas e analisadas através de técnicas cromatográficas, antes e após o sistema de purificação do biocombustível. O perfil de vazão de biogás igual a 18 m3/dia indica uma possibilidade de aplicação desse biocombustível como recurso energético. Durante os testes de transformação de biogás em biometano, empregando coluna de lavagem com solução alcalina, foi obtido um teor de metano de 75% quando se empregou solução de hidróxido de cálcio com concentração igual a 0.16 mol/L, o que aponta para a obtenção de um biocombustível com uma melhor qualidade após sistema de purificação, atendendo as características preconizadas pela Agência Nacional do Petrôleo (ANP), com fins de aplicação industrial.
Medical Geology Related to Different Trace Elements Deficiency and Toxicity Diseases
Authors: Ganguly Pekham
Published: September 2023

Abstract: Medical geology is an emerging discipline that, broadly defined, examines the public health impacts of geologic materials and geologic processes. Medical Geology, the study of the impacts of geologic materials and processes on animal and human health, is a dynamic emerging discipline bringing together the geosciences, biomedical, and public health communities to solve a wide range of environmental health problems. Among the Medical Geology described in this review are examples of both deficiency and toxicity of trace element exposure. Goiter is a widespread and potentially serious health problem caused by deficiency of iodine. In many locations the deficiency is attributable to low concentrations of iodine in the bedrock. Similarly, deficiency of selenium in the soil has been cited as the principal cause of juvenile cardiomyopathy and muscular abnormalities. Overexposure to arsenic is one of the most widespread Medical Geology problems affecting more than one hundred million people in Bangladesh, India, China, Europe, Africa and North and South America. The arsenic exposure is primarily due to naturally high levels in groundwater but combustion of mineralized coal has also caused arsenic poisoning. Dental and skeletal fluorosis also impacts the health of millions of people around the world and, like arsenic, is due to naturally high concentrations in drinking water and, to a lesser extent, coal combustion. Other Medical Geology issues described include geophagia, the deliberate ingestion of soil, exposure to radon, and ingestion of high concentrations of organic compounds in drinking water. Geosciences and biomedical/public health researchers are teaming to help mitigate these health problems.
Enfermedad de Pompe: historia, epidemiología, fisiopatología y manifestaciones clínicas
Authors: Millán-Pérez Sonia Patricia , Chacón-Valencia Sergio Esteban , Bolaños-Almeida Carlos Ernesto , Pardo-Cardozo Nathalia Andrea , Forero-Botero César Augusto
Published: September 2023

Introducción: la enfermedad de Pompe o glucogenosis tipo II pertenece al grupo de las miopatías metabólicas y es producida por la deficiencia parcial o total de la enzima alfa glucosidasa ácida. La ausencia/déficit de esta enzima genera un almacenamiento de glucógeno en el interior de los lisosomas en diversos tejidos, incluidos el músculo esquelético, el miocardio y las células del músculo liso. Se trata de una enfermedad multisistémica que puede tener un inicio temprano o tardío de los síntomas.
Contenidos: en este artículo se describirán los aspectos históricos de la enfermedad, su fisiopatología y sus manifestaciones clínicas, con el énfasis puesto en su inicio temprano o tardío.
Conclusiones: es necesario reconocer la enfermedad de Pompe debido a que esta patología es susceptible de tratamiento.
Predictive Analytics for Blood Supply Chain Management and Data Security in Healthcare System
Authors: Muthukudaarachchi Vinusha , Pushmika Ashini , Wijesekara Yuthishka , Naragala Tharushi , Abeygunawardhana Pradeep K.W. , Liyanage Rangi
Published: September 2023

The Web-Based Blood Bank and Donation Management System (BBDMS)
presents a comprehensive solution to optimize blood donation processes
by integrating data security, predictive analytics powered by machine
learning, and efficient management strategies. With a focus on
safeguarding sensitive information and enhancing donor recruitment
through ML-driven predictive models, the BBDMS utilizes encryption and
access controls to ensure data integrity. Leveraging advanced data
analytics and machine learning, the system predicts potential blood
donors based on factors like age and location, improving recruitment
efforts. Streamlining blood camp organization and appointment
scheduling, the BBDMS enhances donor engagement and satisfaction.
Moreover, by accurately forecasting blood demand using machine learning
techniques and optimizing stock management, the system aids in efficient
emergency response. Overall, the BBDMS transforms blood donation
processes by enhancing security, prediction accuracy using machine
learning, resource allocation, and emergency preparedness, contributing
to improved public health outcomes and the effectiveness of blood banks
and organizations.
PB ameliorates Hyperglycemia Induced Angiogenesis in DN.
Authors: Mohammed Mostafa Mourad , Rehim Salama R. Abdel , Okasha Ahmed Mohamed M. , El-Mezayen Hatem , Mohammed Doaa Gamal Abdel Nasser , Gomaa Wafaey , Ayad Eman
Published: September 2023

Background: Hyperglycemia contributes to a cascade of
inflammatory response mechanisms in kidneys that result in the
development of renal hypoxia and angiogenesis with subsequent chronic
renal failure. Under a certain degree of hyperglycemia, the kidney
possesses self-protection mechanisms through adaptation to hyperglycemia
and hypoxia. As the hypoxia-inducible factor-1α (HIF-1α)/vascular
endothelial growth factor (VEGF) axis is a key pathway for
neovascularization, the inhibition of this axis is a target for renal
angiogenesis therapy. Methods: Male Sprague–Dawley rats were
exposed to hyperglycemia and subdivided into four groups, namely groups
1, 2, 3 and 4. Renal tissue samples were processed and analyzed to
determine pathological and morphological changes, the gene expression of
HIF-1α, VEGF, inflammation factor and effect of treatment.
Results: We found that with hyperglycemia, HIF1α and VEGF
expression were increased, inflammatory mediator IL-6 increased and
vascular changes in the kidney tissues are severe in diabetic group. In
contrast, the changes are minimal in the treated group. The expression
of HIF-1α increased as well as the expression of VEGF, but VEGF
expression in group 3 was the lowest. Group 3 had lower levels of IL-6,
and least vascular changes. The results revealed that PB treatment
suppressed the development of angiogenesis and DN. Conclusion:
These findings suggest that affecting the HIF-1α/VEGF signaling pathway
to regulate angiogenesis after infliction of hyperglycemic kidney injury
may provide clues for the development of novel CKD treatments.
A Rare Hemoglobinopathy Duo: Hb ADANA x Hb SEA in a One-Year-Old Patient
Authors: Baroudi Dr.Mustafa Mounir Al , Faheem Youmna Ayman , Saddik Samia Emad Al , John Steffi Paulson
Published: September 2023

Female thalassemia carriers are often symptom-free until their prenatal
visit, discovering their fetus has hydrops fetalis. However, a single
alpha-thalassemia gene mutation doesn’t cause this. It requires an
additional mutation from both parents, impacting the fetus’s genotype
and phenotype. Here, we present a case of a one-year-old girl with an
uncommon alpha-thalassemia type. Genetic testing revealed the mother’s
heterozygous south-east Asian (SEA) α-gene deletion and the husband’s
heterozygosity for a rare non-deletional alpha-thalassemia mutation,
hemoglobin (Hb) ADANA. (1-3)