bluuebunny/crossref_metadata_2025 huggingface dataset:
Development, Performance, and Microscopic Analysis of New Anchorage Agent with Heat Resistance, High Strength, and Full Length
Authors: Liu Xiaohu , Yao Zhishu , Xue Weipei , Li Xiang
Published: April 2019

To solve the difficult problems of failure of pretensioned bolt supports under high ground pressure and temperature, a new kind of anchorage agent with excellent performance is developed. First, the selection and compounding of raw materials were conducted. The new anchorage agent was obtained by modifying the PET resin by mixing with a phenolic epoxy vinyl ester resin (FX-470 resin) and adding a KH-570 silane coupling agent. Then, the viscosity, thermal stability, compressive strength under different temperatures, and anchorage capacity of the new anchorage agent were tested. Moreover, the best proportion ratio of anchorage agent by mixing resin : coarse stone powder : fine stone powder : accelerator : curing agent : KH-570 = 100 : 275 : 275 : 1 : 32.5 : 1 is obtained. The test results showed that, with the addition of a KH-570 silane coupling agent, the viscosity decreased significantly, thereby solving the difficult technical problems of pretensioned bolt supports in full-length anchorage support. Compared with the conventional anchorage agent, the compressive strength of the new anchorage agent increased by 20.4, 82.5, 118.2, and 237.5% at 10, 50, 80, and 110°C, respectively, and the anchorage capacity increased by 4.7, 8.7, 40.2, and 62.9% at 30, 50, 80, and 110°C, respectively. Finally, the enhancement in compressive strength and heat-resistant mechanism are revealed through microanalysis.
Autoregressive Neural Network for Cloud Concentration Forecast from Hemispheric Sky Images
Authors: Crisosto Cristian
Published: April 2019

We present here a new method to predict cloud concentration five minutes in advance from all-sky images using the Artificial Neural Networks (ANN). An autoregressive neural network with backpropagation (Ar-BP) was created and trained with four years of all-sky images as inputs. The pictures were taken with a hemispheric sky imager fixed on the roof at the Institute of Meteorology and Climatology (IMUK) of the Leibniz Universität Hannover, Hannover, Germany. Firstly, a statistical method is presented to obtain key information of the pictures. Secondly, a new image-processing algorithm is suggested to optimize the cloud detection process starting with the Haze Index. Finally, the cloud concentration five minutes in advance at the IMUK is forecasted using machine learning methods. A persistence model forecast to provide a reference for comparison was generated. The results are quantified in terms of the root mean square error (RMSE) and the mean absolute error (MAE). The new algorithm reduced both the RMSE and the MAE of the prediction by approximately 30% compared to the reference persistence model under diverse cloud conditions. The new algorithm could be used as a tool for the stable maintenance of the network for the transmission system operators, i.e., the primary control reserve (within 30 seconds) and the secondary control reserve (within 5 minutes).
Eupatilin Inhibits Renal Cancer Growth by Downregulating MicroRNA-21 through the Activation of YAP1
Authors: Zhong Weifeng , Wu Zhiming , Chen Nanhui , Zhong Kaihua , Lin Yifeng , Jiang Huiming , Wan Pei , Lu Shanming , Yang Lawei , Liu Siping
Published: April 2019

Renal cell carcinoma (RCC) is the second most common human urinary tumor. Eupatilin is the main active ingredient of the traditional Chinese medicineArtemisia asiatica. The effect of Eupatilin on RCC and the underlying mechanism remain unknown. Here, we investigated the anticancer effects and mechanisms of Eupatilin in RCCin vivoandin vitro, laying an experimental foundation for the clinical application of Eupatilin in the treatment of RCC. The results showed that Eupatilin significantly inhibited 786-O cell viability and migration and promoted apoptosis. Eupatilin inhibited the expression of miR-21 in 786-O cells, and overexpression of miR-21 suppressed the effect of Eupatilin on viability, apoptosis, and migration in 786-O cells. Eupatilin inhibited the growth of renal tumors in nude mice by downregulating miR-21. YAP1, which was identified as a target of miR-21, showed significantly lower expression in RCC tissues than in healthy tissues. miR-21 significantly inhibited YAP1 protein expression in 786-O cells and tumor tissues isolated from nude mice, and YAP1 attenuated the effect of miR-21 on the viability, apoptosis, and migration of 786-O cells. In conclusion, Eupatilin inhibited the expression of miR-21, which mediated the proapoptotic and antimigratory effects of Eupatilin by suppressing YAP1 in renal cancer cells. These results suggested that Eupatilin could be a potent agent for the treatment of RCC.
Karyopherin Alpha 2-Expressing Pancreatic Duct Glands and Intra-Islet Ducts in Aged Diabetic C414A-Mutant-CRY1 Transgenic Mice
Authors: Okano Satoshi , Yasui Akira , Kanno Shin-ichiro , Satoh Kennichi , Igarashi Masahiko , Nakajima Osamu
Published: April 2019

Our earlier studies demonstrated that cysteine414- (zinc-binding site of mCRY1-) alanine mutant mCRY1 transgenic mice (Tg mice) exhibit diabetes characterized by the reduction of β-cell proliferation and by β-cell dysfunction, presumably caused by senescence-associated secretory phenotype- (SASP-) like characters of islets. Earlier studies also showed that atypical duct-like structures in the pancreas developed age-dependently in Tg mice. Numerous reports have described that karyopherin alpha 2 (KPNA2) is highly expressed in cancers of different kinds. However, details of the expression of KPNA2 in pancreatic ductal atypia and in normal pancreatic tissues remain unclear. To assess the feature of the expression of KPNA2 in the development of the ductal atypia and islet architectures, we scrutinized the pancreas of Tg mice histopathologically. Results showed that considerable expression of KPNA2 was observed in pancreatic β-cells, suggesting its importance in maintaining the functions of β-cells. In mature stages, the level of KPNA2 expression was lower in islets of Tg mice than in wild-type controls. At 4 weeks, the expression levels of KPNA2 in islets of Tg mice were the same as those in wild-type controls. These results suggest that the reduction of KPNA2 might contribute to β-cell dysfunction in mature Tg mice. Additionally, the formation of mucin-producing intra-islet ducts, islet fibrosis, and massive T cell recruitment to the islet occurred in aged Tg mice. In exocrine areas, primary pancreatic intraepithelial neoplasias (PanINs) with mucinous pancreatic duct glands (PDGs) emerged in aged Tg mice. High expression of KPNA2 was observed in the ductal atypia. By contrast, KPNA2 expression in normal ducts was quite low. Thus, upregulation of KPNA2 seemed to be correlated with progression of the degree of atypia in pancreatic ductal cells. The SASP-like microenvironment inside islets might play stimulatory roles in the formation of ductal metaplasia inside islets and in islet fibrosis in Tg mice.
Shear Behavior of Hollow Concrete Block Masonry with Precast Concrete Anti-Shear Blocks
Authors: Yang Xinlei , Wu Hanchen , Zhang Jianxin , Wang Hailiang
Published: April 2019

In order to improve the shear behavior of hollow concrete block masonry, precast concrete anti-shear blocks were proposed to enhance the shear strength of hollow concrete block masonry. Four groups of hollow concrete block masonry triplets with precast concrete anti-shear blocks were tested under shear loading, and their behaviors were compared with a control group. The results show that as the height of precast concrete anti-shear blocks increases, the shear strength of the masonry increases. The maximum shear strength of masonry triplets with precast concrete anti-shear blocks was 234.48 percent higher than that of the control specimens. The shear strength of masonry triplets was mainly determined by the failure of hollow concrete block unit. The majority of specimens exhibited double shear failures; however, these failures showed characteristics of ductile failure to a certain extent. Based on the experimental results, a equation for calculating the shear strength of masonry with precast concrete anti-shear blocks was proposed.
The Physics of Cancer
Authors: White Forest M. , Gatenby Robert A. , Fischbach Claudia
Published: April 2019

While often described as a “disease of the genes,” cancer is, in fact, a complex dynamic system in which evolving cells both affect and are affected by the physical properties of their environment. About 10 years ago, after a number of multidisciplinary workshops and meetings, the NCI leadership embarked on a bold program to systematically integrate physical sciences into cancer biology and treatment through formation of the Physical Sciences-Oncology Network (PS-ON). Here, we highlight key areas in which the two disciplines have been successfully integrated and lessons learned from the first decade of the PS-ON experiment.
Mogamulizumab Treatment Elicits Autoantibodies Attacking the Skin in Patients with Adult T-Cell Leukemia-Lymphoma
Authors: Suzuki Yui , Saito Masato , Ishii Toshihiko , Urakawa Itaru , Matsumoto Asuka , Masaki Ayako , Ito Asahi , Kusumoto Shigeru , Suzuki Susumu , Hiura Masanori , Takahashi Takeshi , Morita Akimichi , Inagaki Hiroshi , Iida Shinsuke , Ishida Takashi
Published: April 2019

Purpose:

The anti-CCR4 mAb, mogamulizumab, offers therapeutic benefit to patients with adult T-cell leukemia-lymphoma (ATL), but skin-related adverse events (AE) such as erythema multiforme occur frequently. The purpose of this study was to determine the mechanisms by which mogamulizumab causes skin-related AEs in patients with ATL.

Experimental Design:

We investigated whether autoantibodies were present in patients’ sera using flow cytometry to determine binding to keratinocytes and melanocytes (n = 17), and immunofluorescence analysis of tissue sections. We analyzed the IgM heavy chain repertoire in peripheral blood mononuclear cells before and after mogamulizumab or other chemotherapy by next-generation sequencing (NGS; n = 16).

Results:

Autoantibodies recognizing human keratinocytes or melanocytes were found in the sera of 6 of 8 patients suffering from mogamulizumab-induced erythema multiforme. In one patient, complement-dependent cytotoxicity (CDC) mediated by autoantibodies against keratinocytes or melanocytes was proportionally related to the severity of the erythema multiforme. The presence of autoantibodies in the epidermis was confirmed in all biopsy specimens of mogamulizumab-induced erythema multiforme (n = 12). Furthermore, colocalization of autoantibodies and C1q, suggesting the activation of CDC, was observed in 67% (8/12). In contrast, no autoantibody or C1q was found in ATL tumor skin lesions (n = 13). Consistent with these findings, NGS demonstrated that IgM germline genes had newly emerged and expanded, resulting in IgM repertoire skewing at the time of erythema multiforme.

Conclusions:

Mogamulizumab elicits autoantibodies playing an important role in skin-related AEs, possibly associated with regulatory T-cell depletion. This is the first report demonstrating the presence of skin-directed autoantibodies after mogamulizumab treatment.
Impact of a Pre-Operative Exercise Intervention on Breast Cancer Proliferation and Gene Expression: Results from the Pre-Operative Health and Body (PreHAB) Study
Authors: Ligibel Jennifer A. , Dillon Deborah , Giobbie-Hurder Anita , McTiernan Anne , Frank Elizabeth , Cornwell MacIntosh , Pun Matthew , Campbell Nancy , Dowling Ryan J.O. , Chang Martin C. , Tolaney Sara , Chagpar Anees B. , Yung Rachel L. , Freedman Rachel A. , Dominici Laura S. , Golshan Mehra , Rhei Esther , Taneja Krishan , Huang Ying , Brown Myles , Winer Eric P. , Jeselsohn Rinath , Irwin Melinda L.
Published: April 2019

Purpose:

Exercise after breast cancer diagnosis is associated with lower cancer-specific mortality, but the biological mechanisms through which exercise impacts breast cancer are not fully understood. The Pre-Operative Health and Body (PreHAB) Study was a randomized window-of-opportunity trial designed to test the impact of exercise on Ki-67, gene expression, and other biomarkers in women with breast cancer.

Experimental Design:

Inactive women with newly diagnosed breast cancer were randomized to an exercise intervention or mind–body control group, and participated in the study between enrollment and surgery (mean 29.3 days). Tumor and serum were collected at baseline and surgery.

Results:

Forty-nine women were randomized (27 exercise, 22 control). At baseline, mean age was 52.6, body mass index was 30.2 kg/m2, and exercise was 49 minutes/week. Exercise participants significantly increased exercise versus controls (203 vs. 23 minutes/week, P < 0.0001). There were no differences in changes of expression of Ki-67, insulin receptor, and cleaved caspase-3 in exercise participants versus controls. KEGG pathway analysis demonstrated significant upregulation of 18 unique pathways between the baseline biopsy and surgical excision in exercise participants and none in control participants (q < 0.1). Top-ranked pathways included several implicated in immunity and inflammation. Exploratory analysis of tumor immune infiltrates demonstrated a trend toward a decrease in FOXP3+ cells in exercise versus control participants over the intervention period (P = 0.08).

Conclusions:

A window-of-opportunity exercise intervention did not impact proliferation but led to alterations in gene expression in breast tumors, suggesting that exercise may have a direct effect on breast cancer.

See related commentary by Koelwyn and Jones, p. 5179
SF2523: Dual PI3K/BRD4 Inhibitor Blocks Tumor Immunosuppression and Promotes Adaptive Immune Responses in Cancer
Authors: Joshi Shweta , Singh Alok R. , Liu Kevin X. , Pham Timothy V. , Zulcic Muamera , Skola Dylan , Chun Hyun Bae , Glass Christopher K. , Morales Guillermo A. , Garlich Joseph R. , Durden Donald L.
Published: April 2019

Macrophages (MΘs) are key immune infiltrates in solid tumors and serve as major drivers behind tumor growth, immune suppression, and inhibition of adaptive immune responses in the tumor microenvironment (TME). Bromodomain and extraterminal (BET) protein, BRD4, which binds to acetylated lysine on histone tails, has recently been reported to promote gene transcription of proinflammatory cytokines but has rarely been explored for its role in IL4-driven MΘ transcriptional programming and MΘ-mediated immunosuppression in the TME. Herein, we report that BET bromodomain inhibitor, JQ1, blocks association of BRD4 with promoters of arginase and other IL4-driven MΘ genes, which promote immunosuppression in TME. Pharmacologic inhibition of BRD4 using JQ1 and/or PI3K using dual PI3K/BRD4 inhibitor SF2523 (previously reported by our group as a potent inhibitor to block tumor growth and metastasis in various cancer models) suppresses tumor growth in syngeneic and spontaneous murine cancer models; reduces infiltration of myeloid-derived suppressor cells; blocks polarization of immunosuppressive MΘs; restores CD8+ T-cell activity; and stimulates antitumor immune responses. Finally, our results suggest that BRD4 regulates the immunosuppressive myeloid TME, and BET inhibitors and dual PI3K/BRD4 inhibitors are therapeutic strategies for cancers driven by the MΘ-dependent immunosuppressive TME.
IL1R8 Deficiency Drives Autoimmunity-Associated Lymphoma Development
Authors: Riva Federica , Ponzoni Maurilio , Supino Domenico , Bertilaccio Maria Teresa Sabrina , Polentarutti Nadia , Massara Matteo , Pasqualini Fabio , Carriero Roberta , Innocenzi Anna , Anselmo Achille , Veliz-Rodriguez Tania , Simonetti Giorgia , Anders Hans-Joachim , Caligaris-Cappio Federico , Mantovani Alberto , Muzio Marta , Garlanda Cecilia
Published: April 2019

Chronic inflammation, including that driven by autoimmunity, is associated with the development of B-cell lymphomas. IL1R8 is a regulatory receptor belonging to the IL1R family, which negatively regulates NF-κB activation following stimulation of IL1R or Toll-like receptor family members. IL1R8 deficiency is associated with the development of severe autoimmune lupus-like disease in lpr mice. We herein investigated whether concomitant exacerbated inflammation and autoimmunity caused by the deficiency of IL1R8 could recapitulate autoimmunity-associated lymphomagenesis. We thus monitored B-cell lymphoma development during the aging of IL1R8-deficient lpr mice, observing an increased lymphoid cell expansion that evolved to diffuse large B-cell lymphoma (DLBCL). Molecular and gene-expression analyses showed that the NF-κB pathway was constitutively activated in Il1r8−/−/lpr B splenocytes. In human DLBCL, IL1R8 had reduced expression compared with normal B cells, and higher IL1R8 expression was associated with a better outcome. Thus, IL1R8 silencing is associated with increased lymphoproliferation and transformation in the pathogenesis of B-cell lymphomas associated with autoimmunity.
Speech Intelligibility in Dysarthrias: Influence of Utterance Length
Authors: Barreto Simone dos Santos , Ortiz Karin Zazo
Published: April 2019

Aim: To analyze the effect of utterance length on the intelligibility of words produced by dysarthric speakers. Methods: A total of 10 adult speakers with dysarthria (5 men and 5 women; mean age 58.8 years, SD 14.1) took part in the study. Six speakers exhibited mild-to-moderate impairment, while 4 had severe-to-extreme impairment, according to scores on the single-words subtest of the Protocol for the Evaluation of Speech Intelligibility in Dysarthrias (PESI). The speakers were recorded producing, by repetition, a list of 25 sentences from the sentence subtest of the PESI plus a list of 25 separate words taken from the same sentence list. The speech samples were sound recorded and subsequently transcribed by 40 listeners. Intelligibility scores were calculated according to the percentage of target words correctly transcribed in each list of stimuli. Results: The intelligibility scores for the target words produced in sentences were lower than the scores obtained by utterance of single words (z = –2.82; p < 0.01). This difference was not consistently due to dysarthria severity. Conclusion: The results of the present study support the hypothesis that utterance length can negatively influence speech intelligibility in people with dysarthria.
Permutations Learning Via Role Playing
Authors: Siligar E.I Pusta , Somakim Somakim , Hapizah Hapizah
Published: April 2019

This research was aimed at producing a learning trajectory, which could help the students to understand the concept of permutations study via role playing activity in the election of chairman and vice-chairman of Intra School Students Organization. The design of this research was Indonesia’s Realistic Mathematics Education approach. The sample of this reasearch were 36 students of the tenth grade of Senior High School No 15 Palembang. The data were obtained from observations, recorded vedeos, photos, students’ sheet activities, and field documentations. The result of this research showed that the learning trajectory could help the students to understand the concept of permutations study. By using role playing activity, the students have determined the administrative committee of chairman and vice-chairman election of Intra School Students Organization from 2, 3, 4, and 5 candidates, which will enable them to choose the number of formed groups arrangement, and to help them in understanding the concept of permutaions from that election.
Strategies of Refusal Speech Act by Javanese Culture-based Students at Darul Ihsan Muhammadiyah Islamic Boarding School Sragen
Authors: Prayitno Harun Joko , Ngalim Abdul , Rohmadi Muhammad , Riyanto Udik
Published: April 2019

The research aims at (a) describing the strategies and identifying the levels of refusal speech act in politeness, and (b) formulating the internalization of polite values in a process of the Javanese culture-based students’ character building. The research was conducted at Darul Ihsan Muhammadiyah Islamic Boarding School Sragen. It employed a descriptive and qualitative, and analytic, critic, and holistic approach. The data sources covered all the students (santri) and teachers (asatidz) in both formal and nonformal situations. The object was the refusal speech act, spoken in the communication at the school. The data were collected with the techniques of content analysis, in-depth interview, and observation. The data were analyzed with a contextual-extralingual method. In conclusion, the results of the research show that: (a) the refusal speech act is performed through indirect (63%) and direct strategies (37%), (b) the refusal speech act is spoken through indirect communication with polite (29%), impolite (56%), cost-benefit (3%), authority (5%), and optionality (5%), and social distance (2%), (c) the internalization of the students’ character building is realized in the forms of model, habit, supervision, advice and suggestion, warning, and sanction. The dominant factors in the internalization process are closely related to the teachers’ roles, Islamic Boarding School’s environment, and politeness building in the learning process. The problems are closely related to the low understanding of politeness, heterogeneous students, and students’ habits.
The Development of Metacognitive Skills-Based Teaching Materials
Authors: Mas'ud Mas'ud , Ahmad Arifin , Arsyad Nurdin
Published: April 2019

It is necessary to develop metacognitive skills-based teaching materials to foster mathematical problem-solving abilities. This research is a research and development. Method used for development is based on [1] using four phases: Design, Construction, Testing, Evaluation and Revision. The criteria used to assess the quality of the learning device refer to the material quality criteria proposed by [2], namely: validity, practicality, effectiveness. Subject of trials in this research are 25 students of XI IPA-4 and 25 students of XI IPA-2. Two indicators of this study are metacognitive skills and problem solving. Metacognitive skills are: prediction skills, planning skills, monitoring skills, and evaluation skills. Indicators of problem solving are: understanding the problem, devising a plan, carrying out the plan, and looking back. The data are collected by giving Tests and questionnaires, and through observations. The research instruments are: questionnaire of validation for teaching materials, student questionnaire responses to instructional materials, observation sheet activities of learners, observation sheets of learning implementation and learning management observation sheet. The result of this research is metacognitive skills-based teaching materials are succeeded (fulfilling the criteria of valid, practical, and effective) to emerge students mathematical problem-solving.
The Influence of Biology Learning Using Concept Attainment Model on Student’s Cognitive Learning Achievement
Authors: Yuliati Yuliati , Maridi Maridi , Masykuri Mohammad
Published: April 2019

This research aimed to find out the difference of cognitive learning achievement between students taught with Concept Attainment Model and those taught with Discovery Learning model. This study was a quasi-experimental research. The population of research was the 12th Science graders of SMAN 1 Karas of Magetan Regency in school year of 2016/2017. The sample was taken using cluster random sampling technique, consisting of two grades: the 12th Science 4 grade as the first experiment class using Concept Attainment Model and the 12th Science 3 grade as the second experiment class using Discovery Learning model. Technique of collecting data used was t-test technique for data of students’ cognitive learning outcome. Data analysis was carried out using unpaired two-sample variance analysis. The result of research showed there was a difference of cognitive learning outcome between the students treated with learning using Concept Attainment Model and those treated with learning using Discovery Learning. The cognitive learning achievement of students taught with Concept Attainment Model was higher than that of those taught with Discovery Learning.
Towards a Comprehensive Conception of Mathematical Proof
Authors: Ndemo Zakaria , Mtetwa David. J. , Zindi Fred
Published: April 2019

There is overwhelming evidence that students face serious challenges in learning mathematical proof. Studies have found that students possess a superficial understanding of mathematical proof. With the aim of contributing to efforts intended to develop a comprehensive conception of mathematical proof, literature search was conducted to identify areas where research could be directed in order to increase proof understanding among students. To accomplish this goal, literature on modes of reasoning involved in proof construction, ideas on the classification of activities that constitute a proof path, and categories of proof understanding are exemplified using mathematical content drawn from Real Analysis. These exemplifications were used to illustrate the connections between modes of reasoning and levels of proof understanding. With regard to students’ fragile grasp of mathematical proof this critique of literature has revealed that many previous studies have given prominence to proof validations while there is lack of crucial interplay between structural and inductive modes of reasoning during proving by students. Hence, it is suggested in this paper that current research could also focus on mechanisms that promote an analytic conceptions of mathematical proof that are comprehensive enough to allow students to engage in more robust proof constructions.
Starting torque and torque ripple reduction using SVPWM based vector control of induction motor with nine-level cascaded multilevel inverter fed with solar PV power
Authors: Shashibhushan Shashibhushan , Sonoli Savita
Published: April 2019

This paper is an attempt to develop an Induction Motor Drive System with Multilevel Inverter topology for reduced torque ripple application. A Nine level-cascaded multilevel inverter is developed for the induction motor drive with SVPWM control powered by boost converter fed using solar PV supply. The SVPWM control based implementation of vector control using a multilevel inverter topology needs a multilevel SVPWM control technique, which is implemented in this paper. The Solar power supplied is applied with the MPPT technique and the supplied DC power is fed to the three phase cascaded 9 level multilevel inverter. The vector control of induction motor is carried out using the SVPWM technique on the multilevel topology. The torque ripple reduction in the output is observed and compared with the vector control of induction motor. Matlab based implementation is carried out and the results are tabulated and inferred.
Modeling and simulation of quasi-Z-source indirect matrix converter for permanent magnet synchronous motor drive
Authors: Nori Ahmed Muthenaa , Hassan Turki K.
Published: April 2019

This paper aims to use a three-phase quasi-Z-source indirect matrix converter (QZSIMC) to expand the voltage gain for application in a Permanent Magnet Synchronous Motor (PMSM) drives. In this converter, a unique quasi-Z-source network (QZSN) connects the three-phase input voltage to conventional indirect matrix converter (IMC) in order to boost the supply voltage for PMSM because of limited voltage gain of IMC. Dual space vector modulation (SVM) is utilized to control the QZSIMC. The amplitude of output voltage for quasi-Z-source network is raised by the shoot-through of the rectifier stage, so the system voltage gain becomes greater. Through selecting the optimized value of shoot through duty ratio (D) and modulation index of the rectifier stage (), the drive system can automatically regulate the output voltage of QZSIMC during conditions of voltage sag , step change in load torque and reference speed change when the required voltage gain of QZSIMC is more than 0.866 depending on input voltage and required output voltage.The vector control technique based on closed loop speed control is proposed to control speed of the motor from zero to rated speed which is combined with the proposed converter to obtain the motor drive. The simulation results with MATLAB /Simulink 2015 are obtained to validate performance of PMSM drive.
Fractional PID controlled cascaded flyback switched mode power supply with enhanced time domain response
Authors: Sasikala K. , Kumar R. Krishna
Published: April 2019

This work compacts with the modeling, simulation, and application of a Fractional Order Proportional Integral Differential (FOP-I-D) controlled Cascaded Flyback Switched Mode Power Supply (CFSMPS) system. It recommends Parallel cascaded flyback converter for the production of essential DC voltage from the input supply voltage. The output from CFSMPS is regulated by using closed loop configuration. The simulation of Closed-loop Proportional-Integral (PI) and FOP-I-D controlled CFSMPS system has been done and the results of the systems are related. The outcomes signify that the FOP-I-D based system has presented an enhanced response to represent as similar to the PI controlled CFSMPS system. The FOP-I-D controlled CFSMPS system has benefits like decreased steady-state error and enhanced time-domain response.
Modos de contato na música cênica contemporânea
Authors: Bonin Gustavo
Published: April 2019

Com base nas direções propostas pelo texto “As condições semióticas das mestiçagem” de Claude Zilberberg, o artigo irá circunscrever a Música Cênica Contemporânea como uma prática que coloca em jogo o contato entre elementos musicais e cênicos, ambos regidos por uma organização musical subjacente. Na guia das diversas vertentes da música contemporânea e experimental, alguns autores ressaltam a presença cênica dos concertos de música utilizando estratégias de iluminação, figurino, gestualidade, encenação etc. Propomos observar as estratégias de dominâncias, transportes e ambivalências entre as presenças musicais e as presenças cênicas, através da configuração gradativa e aspectual dos modos de contato. Zilberberg prevê quatro estados aspectuaise graduais de interação, que vai da mais próxima à mais afastada [fusão – mescla – contiguidade – separação], e também duas sintaxes elementares da mistura, a de participaçãoe a de privação, em que se representa, aspectualmente, a movimentação das grandezas que constituem as presençasem contato. Por fim, esboçaremos uma descrição da regência musical como uma base sensível que orienta a percepção do sujeito envolvido na prática híbrida de Música Cênica.
Um estudo de caso sobre a brincadeira do fort-da como indício de estruturação do sujeito
Authors: Gonçalves Renata
Published: April 2019

Este artigo teve como objetivo discutir a constituição do sujeito a partir da brincadeira nomeada por Freud como Fort-da. Realizou-se estudo de caso de criança deficiente visual com base nos pressupostos da teoriapsicanalítica, baseando-se em fragmento de fala durante brincadeiras simbólicas entre criança e terapeuta. Observou-se que tal fragmento de fala representou a possibilidade de emergência do sujeito sem o intuito de necessariamente designar diagnóstico estrutural à criança. Portanto, este estudo tornou-se relevante por discutir a possibilidade de estruturação subjetiva de tal criança à luz da articulação lacaniana entre Simbólico e Imaginário e o jogo do Fort-da de Freud.
Teógenes de Tasos
Authors: Sarian Haiganuch
Published: April 2019

No âmbito dos concursos atléticos na Grécia antiga, os vencedores se destacaram de modo excepcional principalmente na vida religiosa. A esse respeito, é significativo o caso verificado na ilha de Tasos, onde o atleta Teógenes teve uma biografia marcante atingindo o estatuto de herói divinizado, a quem os tásios erigiram monumentos e realizaram sacrifícios honrosos. São conclusões que apresentamos ao analisar as fontes literárias, epigráficas e arqueológicas pesquisadas por eminentes helenistas.
O sentido religioso e a função política dos agōnes de Olímpia nas épocas arcaica e clássica
Authors: Laky Lilian De Angelo
Published: April 2019

Este artigo apresenta um breve resumo do estado da arte sobre o santuário de Olímpia como centro religioso e político do mundo grego em época arcaica e clássica. Os jogos olímpicos são discutidos como parte de um fenômeno religioso, político e de identidade grega próprio dos dois períodos. Nessa perspectiva, é discutido o papel dos jogos e do culto de Zeus em Olímpia na mobilização das elites das comunidades políticas gregas e na afirmação de identidades políticas, étnicas e regionais
Práticas curatoriais contemporâneas: autoria, negociações e colaborações
Authors: Sampaio Cunha Clara
Published: April 2019

O artigo discute brevemente a formação dos primeiros museus modernos e a constituição de seus acervos para compreender quando o aparecimento de uma figura que “zelasse” por essas coleções passou a ser solicitada pelo sistema da arte A partir das transformações dos espaços expositivos até o cubo branco moderno – modelo que se firmou e ainda ecoa como resposta para as mais variadas proposições expositivas – surgiria o curador, cuja função se situa entre a instituição, a crítica e a prática artística. No entanto, seria a partir de meados do século XX que a curadoria se firmaria como presença constante no campo da arte, seja por seu papel na formação de público (como mediador dos diálogos entre artistas e exposição), seja por intermediar as cada vez mais complexas relações entre artistas e instituições. Assim, a prática curatorial e seus desafios são discutidos aqui por meio de autores como Terry Smith, Hans Ulrich Obrist e Claire Bishop, e também em exposições como as Number Exhibitions (1969-1973) de Lucy Lippard, When attitudes become form: live in your head (1969) de Harald Szeemann, Magiciens de la Terre (1973) de Jean-Hubert Martin. São exemplos em que questões autorais no trabalho do curador bem como a ideia de um curador-artista se fizeram presentes. Por fim, comentaremos eventos de arte motivados pelo universo doméstico, em que o debate sobre autoria e também sobre aspectos colaborativos borrariam as fronteiras entre práticas artísticas e curatoriais, como em Kitchen Show (1991), em Moradas do Íntimo (Brasília, 2009), Estudos de Recepção (Vitória e Vila Velha, 2015), entre outras.
Representação feminina em tempos de exceção
Authors: Ruggiero Amanda Saba , Rahme Anna Maria A. K.
Published: April 2019

O artigo parte dos conceitos de tempo e representação – estudados por Roger Chartier, com análises sobre a importância das narrativas, enquanto discursos empregados na fixação da(s) memória(s) e a construção da história cultural de um determinado grupo -, para associá-los às proposições curatoriais da exposição Mulheres Radicais: arte latino-americana 1960-1985, uma mostra de criações artísticas femininas resistentes às ditaduras militares que oprimiram a América Latina durante a segunda metade do século XX.
Contemporary Use of Embolic Protection Devices During Saphenous Vein Graft Intervention
Authors: Valle Javier A. , Glorioso Thomas J. , Schuetze Katherine B. , Grunwald Gary K. , Armstrong Ehrin J. , Waldo Stephen W.
Published: April 2019

Background:

Guidelines recommend use of embolic protection devices during percutaneous coronary intervention of saphenous vein grafts, but the use of these devices in contemporary practice is unclear. We thus sought to evaluate the patient characteristics and clinical outcomes associated with embolic protection device use during contemporary saphenous vein graft percutaneous coronary intervention.

Methods and Results:

We identified patients undergoing isolated saphenous vein graft percutaneous coronary intervention in the Veterans Affairs Healthcare System from January 2008 to June 2017. Patient and procedural characteristics associated with embolic protection device use were assessed, as well as unmeasured site variation. A propensity-matched cohort was constructed to compare outcomes at 30 days, including unsuccessful intervention, periprocedural myocardial infarction, and death. We identified 7266 vein graft interventions, and embolic protection was used in 37.9% of cases, with a significant decline over time (
P
=0.001) that was most pronounced from 2014 to 2017 (
P
<0.001). There was significant institutional variation in the use of embolic protection, with a 15.50 (95% credible interval, 9.21–29.71)-fold difference in odds of device use by changing facilities independent of patient or procedural factors. Use of embolic protection was associated with reduced risk of unsuccessful intervention (odds ratio, 0.27; 95% credible interval, 0.17–0.42) and 30-day mortality (odds ratio, 0.56; 95% credible interval, 0.36–0.87).

Conclusions:

Use of embolic protection is decreasing with time and occurs in less than half of vein graft interventions. There is significant site variation in the use of embolic protection independent of patient characteristics, suggesting opportunities for the development of uniform practices to improve outcomes among those undergoing saphenous vein graft percutaneous coronary intervention.
Triglyceride and Triglyceride/HDL (High Density Lipoprotein) Ratio Predict Major Adverse Cardiovascular Outcomes in Women With Non‐Obstructive Coronary Artery Disease
Authors: Prasad Megha , Sara Jaskanwal Deep , Widmer Robert J. , Lennon Ryan , Lerman Lilach O. , Lerman Amir
Published: April 2019

Background

Women with non‐obstructive coronary artery disease have increased cardiovascular morbidity. The role of risk factors in this population has yet to be established. We aimed to study the predictive effect of triglycerides and the triglyceride/high‐density lipoprotein ratio on major adverse cardiovascular events (MACE) in patients with non‐obstructive coronary artery disease, and to explore the role of lipid lowering therapy in modifying this risk.

Methods and Results

This is a prospective cohort study enrolling patients with anginal symptoms referred to the cardiac catheterization laboratory for suspected ischemia, who were subsequently diagnosed with non‐obstructive coronary artery disease, defined as no stenosis >20% on angiography. All patients had baseline laboratory testing and were followed for 7.8±4.3 years for the development of major adverse cardiovascular events. We performed Cox proportional hazard testing to determine the effect of triglycerides on risk of major adverse cardiovascular events among men and women by baseline statin use. A total of 462 patients were included. Median age was 53 (Q1, Q3: 45, 62) years. In a Cox proportional hazard model stratified by statin use adjusting for confounders, among those not on baseline statins, triglycerides were independently predictive of major adverse cardiovascular events in women (per 50 mg/dL risk ratio: hazard ratio 1.25 [95%
CI
: 1.06, 1.47];
P
=0.01). This was not true among men. The interaction between triglycerides and sex, and triglycerides and statin was statistically significant.

Conclusions

Triglyceride levels may play a key role in predicting cardiovascular‐specific risk in women, and statin use may be protective. Further investigation is necessary to better delineate the role of statin use in preventing cardiovascular risk.
Magnitude of the Difference Between Clinic and Ambulatory Blood Pressures and Risk of Adverse Outcomes in Patients With Chronic Kidney Disease
Authors: Ku Elaine , Hsu Raymond K. , Tuot Delphine S. , Bae Se Ri , Lipkowitz Michael S. , Smogorzewski Miroslaw J. , Grimes Barbara A. , Weir Matthew R.
Published: April 2019

Background

Obtaining 24‐hour ambulatory blood pressure (
BP
) is recommended for the detection of masked or white‐coat hypertension. Our objective was to determine whether the magnitude of the difference between ambulatory and clinic
BP
s has prognostic implications.

Methods and Results

We included 610 participants of the AASK (African American Study of Kidney Disease and Hypertension) Cohort Study who had clinic and ambulatory BPs performed in close proximity in time. We used Cox models to determine the association between the absolute systolic
BP
(
SBP
) difference between clinic and awake ambulatory BPs (primary predictor) and death and end‐stage renal disease. Of 610
AASK
Cohort Study participants, 200 (32.8%) died during a median follow‐up of 9.9 years; 178 (29.2%) developed end‐stage renal disease. There was a U‐shaped association between the clinic and ambulatory
SBP
difference with risk of death, but not end‐stage renal disease. A 5– to <10–mm Hg higher clinic versus awake
SBP
(white‐coat effect) was associated with a trend toward higher (adjusted) mortality risk (adjusted hazard ratio, 1.84; 95%
CI,
0.94–3.56) compared with a 0– to <5–mm Hg clinic‐awake
SBP
difference (reference group). A ≥10–mm Hg clinic‐awake
SBP
difference was associated with even higher mortality risk (adjusted hazard ratio, 2.31; 95% CI, 1.27–4.22). A ≥−5–mm Hg clinic‐awake SBP difference was also associated with higher mortality (adjusted hazard ratio, 1.82; 95% CI, 1.05–3.15) compared with the reference group.

Conclusions

A U‐shaped association exists between the magnitude of the difference between clinic and ambulatory
SBP
and mortality. Higher clinic versus ambulatory BPs (as in white‐coat effect) may be associated with higher risk of death in black patients with chronic kidney disease.
White Coat and Masked Hypertension in Chronic Kidney Disease: Importance of the Difference Between Office and Out‐of‐Office Blood Pressure Measurements
Authors: Parati Gianfranco , Ochoa Juan Eugenio , Bilo Grzegorz
Published: April 2019

See Article
Ku et al
Exact topological inference of the resting-state brain networks in twins
Authors: Chung Moo K. , Lee Hyekyoung , DiChristofano Alex , Ombao Hernando , Solo Victor
Published: April 2019

A cycle in a brain network is a subset of a connected component with redundant additional connections. If there are many cycles in a connected component, the connected component is more densely connected. Whereas the number of connected components represents the integration of the brain network, the number of cycles represents how strong the integration is. However, it is unclear how to perform statistical inference on the number of cycles in the brain network. In this study, we present a new statistical inference framework for determining the significance of the number of cycles through the Kolmogorov-Smirnov (KS) distance, which was recently introduced to measure the similarity between networks across different filtration values by using the zeroth Betti number. In this paper, we show how to extend the method to the first Betti number, which measures the number of cycles. The performance analysis was conducted using the random network simulations with ground truths. By using a twin imaging study, which provides biological ground truth, the methods are applied in determining if the number of cycles is a statistically significant heritable network feature in the resting-state functional connectivity in 217 twins obtained from the Human Connectome Project. The MATLAB codes as well as the connectivity matrices used in generating results are provided at http://www.stat.wisc.edu/∼mchung/TDA .
The species intermediate between Hieracium petrovae and H. olympicum (Asteraceae): a treatment of H. kritschimanum and description of a new species from Greece
Authors: SZELĄG ZBIGNIEW , VLADIMIROV VLADIMIR
Published: April 2019

Hieracium kritschimanum is neotypified with specimens collected in the type locality in Bulgaria. The etymology and original spelling of the species epithet of H. kritschimanum are clarified. Hieracium pangaeum, which combines the morphological features of H. petrovae and H. olympicum, is described from northern Greece. Both species are illustrated with photos of herbarium specimens. A distribution map of H. petrovae, including its first records from Greece, is provided.
A new genus and species of Tentyriini (Coleoptera: Tenebrionidae) from sand dunes in Namaqualand, South Africa
Authors: SCHAWALLER WOLFGANG
Published: April 2019

Archinamaqua gen. n. lyleae sp. n. (Pimeliinae Latreille, 1802, Tentyriini Eschscholtz, 1831) is described from the sand dunes of Namaqualand in northwestern South Africa. It is related to the genera Broomium Koch, 1950 and Archinamibia Koch, 1952. All these taxa are wingless and highly adapted nocturnal sand dwellers in dry habitats of the same area in northwestern South Africa and southern Namibia.
Skiallagma baueri Förster 1906, a geographically misplaced damselfly, is a junior synonym of Xiphiagrion cyanomelas Selys 1876 (Odonata: Coenagrionidae)
Authors: GARRISON ROSSER W.
Published: April 2019

Based on comparison of specimens and descriptions, Skiallagma baueri Förster, 1906, described from São Paulo State, Brazil and known only from its type series, is found to be a junior synonym of Xiphiagrion cyanomelas Selys, 1876, a species from the Philippines and Southeast Asia.
Simultaneous evidence for a new species of Torrenticola Piersig, 1896 (Acari, Hydrachnidia) from Montenegro
Authors: PEŠIĆ VLADIMIR , VALDECASAS ANTONIO G. , GARCÍA-JIMENEZ RICARDO
Published: April 2019

A new water mite, Torrenticola lukai n. sp. (Hydrachnidia, Torrenticolidae), is described from running waters in NorthernMontenegro. The new species is probably a sister species of Torrenticola lundbladi (Viets, 1930), a little documented spe-cies known from central Spain, which is redescribed based on recently collected new material. Morphological data hasbeen obtained with a bright field transmission microscopy and Laser Scanning Confocal Microscopy (LSCM), the latterallowing a realistic representation of the animals external morphology. Voucher specimens provided the DNA from whichbarcode sequences were obtained. External morphology and molecular data confirm that both species are clearly distin-guishable and diagnosticable. A key is given for the males of European species characterized by shoulder platelets fused to the dorsal plate.
Sea cucumbers collected by the Kermadec Biodiscovery Expedition 2011 (Echinodermata: Holothuroidea: Apodida and Dendrochirotida)
Authors: O’LOUGHLIN P MARK , VANDENSPIEGEL DIDIER
Published: April 2019

Three shallow holothuroid species are recorded for the rocky shoreline of the Kermadec Islands. The new apodid speciesChiridota kermadeca sp. nov. is described. Two dendrochirotid species are reported, both previously found in New Zealand: Plesiocolochirus ignavus (Ludwig, 1875) and Pseudocnus sentus O’Loughlin & Alcock, 2000.Trois espèces peu profondes d’holothuries ont été observées sur le rivage rocheux des îles de Kermadec. Deux d’entreelles appartiennent à deux espèces de dendrochirotid également connues de Nouvelle Zélande: Plesiocolochirus ignavus(Ludwig, 1875) et Pseudocnus sentus O’Loughlin & Alcock, 2000. La troisième espèce: Chiridota kermadeca sp. nov., nouvelle pour la science, est décrite.
Osteological description of Pseudopaludicola canga with implications for the taxonomic position of this taxon
Authors: CARDOZO DARÍO , SUÁREZ PABLO
Published: April 2019

Pseudopaludicola canga was described by Giaretta & Kokubum (2003) based on 74 individuals previously assigned to P.mystacalis by Lobo (1995). In the diagnosis of P. canga, the original authors assigned the presence of terminal T-shapedphalanges as a character state for this taxon. However, the osteology of P. canga is not described and the presence of toetips not expanded laterally is a characteristic share with all members of Pseudopaludicola unassigned to any group. In thiswork is describe for first time the osteology of P. canga, re-examining the external morphology providing a new diagnosisand establishing the taxonomic position of P. canga in the framework of phylogenetic hypothesis proposed by Lobo(1995). Additionally, is compared the toe tip digit IV, between P. falcipes and all the species included in the P. pusilla groupand updated the type locality of P. canga. The osteology reveals that P. canga has the toe tips not T-shaped as mentionedby the original authors and this characteristic has important consequences for the diagnosis of the species. Additionally, the erroneous inclusion of P. canga in the P. pusilla group is confirmed by the phylogenetic analysis.