bluuebunny/crossref_metadata_2025 huggingface dataset:
“Three Steps Above Heaven? Really? That’s All Tactic!” New Alternative Masculinities Dismantling Dominant Traditional Masculinity’s Strategies
Authors: Rodrigues-Mello Roseli , Bonell-García Lars , Castro-Sandúa Marcos , Oliver-Pérez Esther
Published: June 2021

Research on preventive socialization of gender violence has contributed abundant empirical evidence that attraction to violence is common among adolescents. This has meant that “bad guys,” or those who reflect the Dominant Traditional Masculinity (DTM) model, are chiefly perceived as appealing, while “good guys” are perceived as good friends but not desirable. The mainstream media tends to reproduce this traditional model of affective-sexual relationships, which has harmful effects on young girls concerning gender and sexuality. However, New Alternative Masculinity men are challenging this traditional and unsatisfactory model of affective-sexual relationships. The 2010 Spanish version of the movie Three Steps above Heaven, a good example of this kind of media product, has proven to greatly impact communicative acts among adolescents. This article explores how this influence on adolescents is because the communicative acts about Hache – the main character in the movie – are full of the language of desire, and his own communicative acts are full of violence. On the one hand, we analyze how Three Steps above Heaven employs communicative acts to enhance the attractiveness of DTM. On the other hand, based on the evidence gathered in a communicative focus group (CFG) addressed to 15- and 16-year-old female adolescents, we analyze how New Alternative Masculinity men are demystifying Hache and the idea of having a “Three Steps Above Heaven” by demonstrating with the powerful language of desire that men like him employ farce strategies. The article includes evidence from interventions with adolescents where discussion of movies like this, with the involvement of New Alternative Masculinity men and grounded in the language of desire, can transform the perception about the sexual-affective relationship in the movie, thus counteracting their negative influence in terms of attraction to violence.
Development and Validation of a Score for Screening Suicide of Patients With Neuroendocrine Neoplasms
Authors: Lu Lili , Shang Yuru , Zechner Dietmar , Mullins Christina Susanne , Linnebacher Michael , Zhang Xianbin , Gong Peng
Published: June 2021

Background: If the diagnosis of neuroendocrine neoplasm (NEN) increases the risk of patients to commit suicide has not been investigated so far. Identifying NEN patients at risk to commit suicide is important to increase their life quality and life expectancy.

Methods and findings: Cancer cases were extracted from the Surveillance, Epidemiology, and End Results program and were divided into the NEN and the non-NEN cohorts. Subsequently, the NEN patients were randomly split into a training data set and a validation data set. Analyzing the training data set, we developed a score for assessing the risk to commit suicide for patients with NEN. In addition, we validated the score using the validation data set and evaluated, if this score could also be applied to other cancer entities by using the test data set, a non-NEN cohort. The odds ratio (OR) of suicide between NEN and non-NEN patients was determined. Moreover, the performance of a score was evaluated by the receiver operating characteristic curve and the area under the curve (AUC). Compared to non-NEN, NEN significantly increased the risk of suicide to 1.8-fold (NEN vs. non-NEN; OR, 1.832; P < 0.001). In addition, we observed that age, gender, race, marital status, tumor stage, histologic grade, surgery, and chemotherapy were associated with suicide among NEN patients; and a synthesized score based on these factors could significantly distinguish suicide individuals from non-suicide individuals in the training data set (AUC, 0.829; P < 0.001) and in the validation data set (AUC, 0.735; P < 0.001). This score also had a good performance when it was assessed by the test data set (AUC, 0.690; P < 0.001). This demonstrates that the score might also be applicable to other cancer entities.

Conclusions: This population-based study suggests that NEN patients have a higher risk of suicide than non-NEN patients. In addition, this study provided a score, which can identify NEN patients at high-risk of committing suicide. Thus, this score in combination with current screening and prevention strategies for suicide may improve life quality and life expectancy of NEN patients.
Longitudinal Associations Between Energy Drink Consumption, Health, and Norm-Breaking Behavior Among Swedish Adolescents
Authors: Svensson Åsa , Warne Maria , Gillander Gådin Katja
Published: June 2021

Objectives: To describe the intake of energy drinks (EDs) among a sample of Swedish adolescents while considering health-related variables, and to investigate the longitudinal associations between ED consumption, health, and norm-breaking behavior. Longitudinal studies on this topic are scarce.

Methods: Questionnaire data were collected in the northern part of Sweden in 2010–2011 from 1,622 adolescents in grades 6–9. Analyses were performed using a chi-squared test and logistic regression.

Results: Seventy-four percent of the boys and 54% of the girls had consumed EDs (P < 0.001). ED consumption was associated with variables related to low health, low support levels, and norm-breaking behavior. The associations were generally stronger among the girls and the boys who consumed EDs at least once a week. ED consumption was a predictor of worse health and norm-breaking behavior 1 year later. Adjusted odds ratios ranged from 1.53 (95% CI: 1.07, 2.20; school-related stress) to 4.88 (95% CI: 2.28, 10.43; gaming-related truancy).

Conclusions: Health promotion activities benefit from a broad approach but could focus on girls who consume EDs and those boys with the highest consumption levels.
A Cross-Sectional Study Comparing Two Opt-Out HIV Testing Strategies in the Out-Patient Setting
Authors: Tam Greta , Wong Samuel Yeung Shan
Published: June 2021

Background: HIV infections are generally asymptomatic, leading to undetected infections and late-stage diagnoses. There are a lack of acceptable testing strategies for routine opt-out HIV screening. Our aim was to evaluate and compare the diagnostic yield of routine opt-out HIV testing strategies in two out-patient settings in a low HIV prevalence country: The public primary care and specialist out-patient care setting

Methods: A cross-sectional study was conducted in a primary care clinic over a four-week period in 2016 to 2017 and in a specialist out-patient clinic over a concurrent 11-month period. Patients were invited to complete a questionnaire assessing demographic characteristics, acceptance of opt-out HIV testing as a policy in all out-patient clinics in Hong Kong and reasons if refusing the HIV test. All respondents were offered an HIV test.

Results: This study included 648 and 1,603 patients in the primary care and specialist out-patient clinic, respectively. Test acceptability was 86 and 87% in the primary care and specialist out-patient setting, respectively. Test uptake was 35 and 68% in the primary care and specialist out-patient setting, respectively. No HIV infections were detected.

Conclusion: Opt-out HIV testing during routine blood taking in the specialist out-patient setting achieved a high test uptake and acceptability. In contrast, opt-out HIV testing using rapid finger-prick tests in the primary care setting was not effective.
Crowding-Out or Crowding-In: Government Health Investment and Household Consumption
Authors: Cheng Hao , Zhi Yu-Peng , Deng Zi-Wei , Gao Qing , Jiang Rui
Published: June 2021

This paper explores the relationship of government health investment and household consumption by applying a panel fixed effects model and Sobel-Goodman mediation tests to inland Chinese provinces. The empirical results highlight that government health investment has a crowding-in effect and can thus promote household consumption. Furthermore, the promotion effect on non-medical health consumption is greater than that on medical health consumption. The promotion effect of government health investment on rural household consumption is higher than that on urban household consumption, and the promotion effect on household consumption for northern provinces is higher than that in southern provinces. This heterogeneous effect is closely related to the difference between urban and rural development; and the economic levels of the northern and South regions. The mediation tests found that government health investment mainly promotes regional economic growth, and then increases household consumption. In the economic and social development process, the government should implement more effective medical and health care measures to increase social medical and health investment to improve the consumption level of households.
Gene Regulation Network of Prognostic Biomarker YAP1 in Human Cancers: An Integrated Bioinformatics Study
Authors: Wu Baojin , Tang Xinjie , Ke Honglin , Zhou Qiong , Zhou Zhaoping , Tang Shao , Ke Ronghu
Published: June 2021

Background: Yes-associated protein 1 (YAP1) is the main downstream effector of the Hippo signaling pathway, which is involved in tumorigenesis. This study aimed to comprehensively understand the prognostic performances of YAP1 expression and its potential mechanism in pan-cancers by mining databases.

Methods: The YAP1 expression was evaluated by the Oncomine database and GEPIA tool. The clinical significance of YAP1 expression was analyzed by the UALCAN, GEPIA, and DriverDBv3 database. Then, the co-expressed genes with YAP1 were screened by the LinkedOmics, and annotated by the Metascape and DAVID database. Additionally, by the MitoMiner 4.0 v tool, the YAP1 co-expressed genes were screened to obtain the YAP1-associated mitochondrial genes that were further enriched by DAVID and analyzed by MCODE for the hub genes.

Results: YAP1 was differentially expressed in human cancers. Higher YAP1 expression was significantly associated with poorer overall survival and disease-free survival in adrenocortical carcinoma (ACC), brain Lower Grade Glioma (LGG), and pancreatic adenocarcinoma (PAAD). The LinkedOmics analysis revealed 923 co-expressed genes with YAP1 in adrenocortical carcinoma, LGG and PAAD. The 923 genes mainly participated in mitochondrial functions including mitochondrial gene expression and mitochondrial respiratory chain complex I assembly. Of the 923 genes, 112 mitochondrial genes were identified by MitoMiner 4.0 v and significantly enriched in oxidative phosphorylation. The MCODE analysis identified three hub genes including CHCHD1, IDH3G and NDUFAF5.

Conclusion: Our findings showed that the YAP1 overexpression could be a biomarker for poor prognosis in ACC, LGG and PAAD. Specifically, the YAP1 co-expression genes were mainly involved in the regulation of mitochondrial function especially in oxidative phosphorylation. Thus, our findings provided evidence of the carcinogenesis of YAP1 in human cancers and new insights into the mechanisms underlying the role of YAP1 in mitochondrial dysregulation.
Italian Tracing System for Water Buffalo Milk and Processed Milk Products
Authors: Cappelli Giovanna , Di Vuolo Gabriele , Gerini Oreste , Noschese Rosario , Bufano Francesca , Capacchione Roberta , Rosini Stefano , Limone Antonio , De Carlo Esterina
Published: June 2021

This document describes the development of a tracing system for the buffalo supply chain, namely an online computer system in which farmers, dairies, and brokers must maintain records of the production of milk through to the production of derivatives. The system is jointly used throughout the Italian national territory by the Istituto Zooprofilattico Sperimentale del Mezzogiorno (IZSM) and the Sistema Informativo Agricolo Nazionale Italiano (SIAN), after being made mandatory and regulated with the publication of the Ministerial Decree of 9 September 2014. Farmers are obligated to communicate their daily production of bulk milk, the number of animals milked, the number of the delivery note of the sale, and the name of the purchaser; within the first week of the month, they must communicate the milk production of each animal milked. Dairies are required to communicate the milk and the processed product (mozzarella, yogurt, etc.) purchased on a daily basis. The intermediaries are required to communicate the daily milk purchased, both fresh and frozen, the semi-finished product, and the sale of the same. The tracing system linked to the project authorized by the Ministry of Health, called “Development, validation and verification of the applicability of an IT system to be used for the management of traceability in the buffalo industry”, provides operators with the monitoring of production and sales in real time through alerts and access logs. Currently, there are 1531 registered farmers, 601 non-PDO dairies, 102 PDO dairies, 68 non-PDO intermediaries, and 17 PDO intermediaries in Italy. The system provides support for the recovery of the buffalo sector; from the analysis of the data extrapolated from the tracing system of the buffalo supply chain for the years 2016 to 2019, this paper highlights that the application of the Ministerial Decree No. 9406 of 9 September 2014 and the tracing of the supply chain have increased the price of buffalo milk at barns from EUR 1.37/kg to EUR 1.55/kg from 2016 to 2019.
Characterization of Fed Cattle Mobility during the COVID-19 Pandemic
Authors: Mijares Sage , Calvo-Lorenzo Michelle , Betts Nick , Alexander Lacey , Edwards-Callaway Lily N.
Published: June 2021

The COVID-19 pandemic had significant consequences on cattle slaughter capacity in the United States. Although industry stakeholders implemented strategies to minimize cattle welfare impacts of increased weights, days on feed (DOF), and increasing temperatures, there were concerns that mobility challenges would be observed at slaughter facilities. The objectives of this study were to characterize mobility in fed cattle during this recovery period and to identify factors impacting mobility. A total of 158 groups of cattle (15,388 animals) from one slaughter facility were included in the study. A 4-point mobility scoring system was used to assess cattle mobility. Cattle at the facility with normal mobility scores were reduced from the historical average of 96.19% to 74.55%. No increase in highly elevated mobility scores was observed. Mobility was impacted by weight, temperature humidity index (THI), distance hauled, sex, and DOF, with results differing by mobility category. Weather was a key contributor to mobility challenges; the relative risk of observing an elevated mobility score was 45.76% greater when the THI changed from No Stress to Mild Stress. Despite the challenges that the industry faced during this period, efforts to minimize negative effects on cattle welfare by enhanced focus on low-stress handling were effective.
Understanding the Awareness, Knowledge, and Opinion of Dairy Cattle Welfare among Dairy Farmers in Keningau, Sabah
Authors: Sadiq Mohammed Babatunde , Song-Lin Sim , Ramanoon Siti Zubaidah , Syed-Hussain Sharifah Salmah , Shaik Mossadeq Wan Mastura , Salisi Mohd Shahrom , Mansor Rozaihan
Published: June 2021

This study aimed to assess the knowledge and opinions about DCW among dairy cattle farmers in Keningau, Sabah. A questionnaire was developed, validated, and administered by hand to 30 farmers. The data collected include farmers’ and farm demographics, and opinions regarding the criteria and indicators of DCW. Only 17 respondents (57%) had heard of “dairy cattle welfare” before this study. Nine farmers (30.0%) had poor knowledge about DCW criteria, whereas 13 (43.7%) and 8 (26.7%) farmers had satisfactory and good knowledge, respectively. Farmers with higher education, larger herd size, high production level, and exotic cattle breeds showed a better understanding. Farmers understood most of the indicators; however, opinions regarding cattle behavior during milking, their physical appearance and their lying down behaviour need to be improved. Nevertheless, 28 respondents ranked their animals’ welfare as either good or satisfactory, which further reflects a poor implementation of DCW measures. The main factors suggested by farmers to influence DCW in their herds were facilities, worker issues, management practices, and animal well-being. In conclusion, guidance from veterinarians and animal welfare specialists may be needed to improve the farmers’ understanding and practices of DCW.
Perceptions of Body Condition, Diet and Exercise by Sports Dog Owners and Pet Dog Owners
Authors: Kluess Heidi A. , Jones Rebecca L. , Lee-Fowler Tekla
Published: June 2021

The purpose of this study was to investigate the variables that contribute to obesity in pet dogs. The working hypothesis was that sports dog owners will better estimate their dog’s body condition and report stronger belief and control over their dogs’ feeding and exercise compared to traditional pet owners. We collected data on 171 pet owners (101 participated in canine sports) for this study. Each owner completed the Dog Owner Attitude Questionnaire. Each dog was measured for percent fat and Purina body condition scale. For the pet dogs, the median Purina body condition score was 6 (too heavy), but for the sports dogs it was 5 (ideal) (p < 0.05 different from pet dogs). The average percent fat for the pet dogs was 19.1 ± 8.6%, and for the sports dogs it was 13.8 ± 5.3% (p < 0.05 different from pet dogs). Among pet owners, 52% were able to correctly estimate their dog’s body condition. Sports dog owners were 57% correct. Pet dog owners fed approximately 60% more per day compared to sports dog owners. Pet and sports dog owners exercised their dog via walking, but sports dog owners reported more activity with the dog, while pet dog owners reported more activity than the dog did by themselves. Overall, pet and sports dog owners put a high value on their dog’s health and well-being, but better education with regard to body condition, feeding and exercise is critical to improve the pet obesity problem.
The Perils of Being Populous: Control and Conservation of Abundant Kangaroo Species
Authors: Croft David Benjamin , Witte Ingrid
Published: June 2021

Australia’s first people managed landscapes for kangaroo species as important elements of their diet, accoutrements and ceremony. This developed and persisted for about 65,000 years. The second wave of colonists from the United Kingdom, Ireland and many subsequent countries introduced familiar domesticated livestock and they have imposed their agricultural practices on the same landscapes since 1788. This heralded an ongoing era of management of kangaroos that are perceived as competitors to livestock and unwanted consumers of crops. Even so, a kangaroo image remains the iconic identifier of Australia. Kangaroo management is shrouded in dogma and propaganda and creates a tension along a loose rural–city divide. This divide is further dissected by the promotion of the consumption of kangaroo products as an ecological good marred by valid concerns about hygiene and animal welfare. In the last decade, the fervour to suppress and micro-manage populations of some kangaroo species has mounted. This includes suppression within protected areas that have generally been considered as safe havens. This review explores these tensions between the conservation of iconic and yet abundant wildlife, and conflict with people and the various interfaces at which they meet kangaroos.
Hedgehogs as a Potential Source of Zoonotic Pathogens—A Review and an Update of Knowledge
Authors: Ruszkowski Jakub J. , Hetman Mateusz , Turlewicz-Podbielska Hanna , Pomorska-Mól Małgorzata
Published: June 2021

Hedgehogs are small insectivorous mammals common across Europe, Asia, and Africa. The increased encroachment of humans into hedgehog habitats has disrupted the human-animal-environment interface. With growing interest in the zoonotic diseases of wildlife species, more studies have been devoted to this subject in the last few years. These papers provide information about known and new emerging diseases. Here we review the current knowledge regarding bacterial, viral, protozoic, and mycotic pathogens with zoonotic potential and assess the importance of hedgehogs as their carriers. Both wild and pet hedgehogs were included in the review. Data from several countries and various hedgehog species were included. The study shows the importance of hedgehogs as carriers of zoonotic diseases and reservoirs of zoonotic pathogens in varied habitats.
Female Scent Activated Expression of Arginase1 and Inducible NO-Synthetase in Lung of BALB/c Male Mice
Authors: Gvozdeva Olga V. , Achasova Kseniya M. , Litvinova Nadezhda A. , Kozhevnikova Elena N. , Litvinova Ekaterina A.
Published: June 2021

Scent signals play an important role in the life of rodents. The scent of the opposite sex can modulate immunity. In mice populations with natural specific pathogens, in males, the scent of a female leads to a redistribution of leukocytes between the lung and the blood, resistance to the influenza virus, and a decrease in antibody production, but not in the development of inflammation induced by bacterial endotoxins. This study demonstrates the effect of the scent of soiled bedding of specific pathogen-free (SPF) status female mice on the percentage of different types of leukocytes in the blood, the expression of Nos2, Arg1, and Foxp3 genes, and the presence of M1/M2 macrophages in the lungs of male BALB/c mice. The scent of the female SPF mice caused a redistribution between T- and B-cells in the blood, the increase in the expression of Nos2, Arg1 genes, and the percentage of M1 type macrophages in the lung, but did not affect the different types of T-cells in the periphery or the lungs. Activation of macrophages in the lung is part of mucosal immunity, which is necessary for males as an adaptive mechanism to prevent potential infection during the search for a sexual partner.
Donnan Potential across the Outer Membrane of Gram-Negative Bacteria and Its Effect on the Permeability of Antibiotics
Authors: Alegun Olaniyi , Pandeya Ankit , Cui Jian , Ojo Isoiza , Wei Yinan
Published: June 2021

The cell envelope structure of Gram-negative bacteria is unique, composed of two lipid bilayer membranes and an aqueous periplasmic space sandwiched in between. The outer membrane constitutes an extra barrier to limit the exchange of molecules between the cells and the exterior environment. Donnan potential is a membrane potential across the outer membrane, resulted from the selective permeability of the membrane, which plays a pivotal role in the permeability of many antibiotics. In this review, we discussed factors that affect the intensity of the Donnan potential, including the osmotic strength and pH of the external media, the osmoregulated periplasmic glucans trapped in the periplasmic space, and the displacement of cell surface charges. The focus of our discussion is the impact of Donnan potential on the cellular permeability of selected antibiotics including fluoroquinolones, tetracyclines, β-lactams, and trimethoprim.
The Long-Term DEHP Exposure Confers Multidrug Resistance of Triple-Negative Breast Cancer Cells through ABC Transporters and Intracellular ROS
Authors: Jadhao Mahendra , Tsai Eing-Mei , Yang Ho-Chun , Chen Yih-Fung , Liang Shih-Shin , Wang Tsu-Nai , Teng Yen-Ni , Huang Hurng-Wern , Wang Li-Fang , Chiu Chien-Chih
Published: June 2021

The characteristics of phthalates had been thought to be similar to endocrine disruptors, which increases cancer risk. The role of phthalates in acquired drug resistance remains unclear. In this study, we investigated the effect of di-(2-ethylhexyl) phthalate (DEHP) on acquired drug resistance in breast cancer. MCF7 and MDA-MB-231 breast cancer cells were exposed to long-term physiological concentration of DEHP for more than three months. Long-exposure DEHP permanently attenuated the anti-proliferative effect of doxorubicin with estrogen receptor-independent activity even after withdrawal of DEHP. Long term DEHP exposure significantly reduced ROS (O2−) level in MDA-MB-231 cells while increased in MCF7 cells. ATP-binding cassette (ABC) transporters possess a widely recognized mechanism of drug resistance and are considered a target for drug therapy. Upregulation of ABC family proteins, ABCB-1 and ABCC-1 observed in DEHP-exposed clones compared to doxorubicin-resistant (DoxR) and parental MDA-MB-231 cells. A viability assay showed enhanced multidrug resistance in DEHP-exposed clones against Dox, topotecan, and irinotecan. Inhibition of ABC transporters with tariquidar, enhanced drug cytotoxicity through increased drug accumulation reversing acquired multidrug resistance in MDA-MB-231 breast cancer cells. Tariquidar enhanced Dox cytotoxicity by increasing intracellular ROS production leading to caspase-3 mediated apoptosis. Activation of PI3K/Akt signaling enhanced proliferation and growth of DEHP-exposed MDA-MB-231 cells. Overall, long-term DEHP exposure resulted in acquired multidrug resistance by upregulating ABCB-1 and ABCC1; apart from proliferation PI3K/Akt may be responsible for acquired drug resistance through ABC transporter upregulation. Targeting ABCB1 and ABCC1 with tariquidar may be a promising strategy for reversing the acquired multidrug resistance of triple-negative breast cancer cells.
Numerical and Experimental Assessment of a Novel Anchored for Intramedullary Telescopic Nails Used in Osteogenesis Imperfecta Fractures
Authors: Aguilar-Pérez Luis Antonio , Sánchez-Cruz José Israel , Flores-Campos Juan Alejandro , Torres-SanMiguel Christopher René
Published: June 2021

Osteogenesis Imperfecta (IO) is a bone disease mainly characterized by the low bone density that produces common fractures in children around 0–7 years. The use of metal implants is a typical treatment of this disease. The intramedullary telescopic nail (ITN) was inspired by the progressive growth in the long bones such as the femur or humerus during children’s aging. This work shows an experimental assessment of the ITN’s, focusing on their fixation; the proposed improvements in the design of the intramedullary nail studied include the separation of the element into two parts for telescopic enlargement, minimal invasive fixation through the distal anchorage, and the double auto-drilled end for fixation on the distal and proximal section of the bone. The samples were manufactured in 316 L steel and mounted on specialized jaws to replicate the implants’ boundary conditions. The experimental test was repeated three times to report the intramedullary telescopic nail’s behavior at three lengths. The results show that the device supports only 79.06 N when not at extension length. However, if the device is extended 150% it will support 46.87 N which suggests that intramedullary telescopic nails can only increase by 25% of their original length before they fail.
Color Point Cloud Registration Algorithm Based on Hue
Authors: Ren Siyu , Chen Xiaodong , Cai Huaiyu , Wang Yi , Liang Haitao , Li Haotian
Published: June 2021

ICP is a well-known method for point cloud registration but it only uses geometric information to do this, which will result in bad results in some similar structures. Adding color information when registering will improve the performance. However, color information of point cloud, such as gray, varies differently under different lighting conditions. Using gray as the color information to register can cause large errors and even wrong results. To solve this problem, we propose a color point cloud registration algorithm based on hue, which has good robustness at different lighting conditions. We extract the hue component according to the color information of point clouds and make the hue distribution of the tangent plane continuous. The error function consists of color and geometric error of two point clouds under the current transformation. We optimize the error function using the Gauss–Newton method. If the value of the error function is less than the preset threshold or the maximum number of iterations is reached, the current transformation relationship is required. We use RGB-D Scenes V2 dataset to evaluate our algorithm and the results show that the average recall of our algorithms is 8.63% higher than that of some excellent algorithms, and its RMSE of 14.3% is lower than that of the other compared algorithms.
Effect of Cold Pressing and Aging on Reduction and Evolution of Quenched Residual Stress for Al-Zn-Mg-Cu T-Type Rib
Authors: Liu Yaoqiong , Zhang Tao , Gong Hai , Wu Yunxin
Published: June 2021

The preparation of the Al-Zn-Mg-Cu T-type rib consisted of forging, quenching, cold pressing, aging and the final machining processes, and the evolution of residual stress played a significant role in its properties and accuracy. Numerical models were established to investigate the evolution and distribution of residual stress for the T-type rib during the quenching and cold pressing processes. The results showed that the distribution of residual stress at the stiffened area is asymmetrical, which is different from the symmetrical distribution at the smooth area. The cold pressing is beneficial for the reduction of residual stress. The stepwise cold pressing resulted in the heterogeneous distribution of residual stress at the stiffened area and the overlap region. Three comparative T-type ribs were conducted, and their residual stresses were measured using X-ray diffraction and the contour method. A stress reduction of 50% can be obtained at the surfaces of the T-type rib through cold pressing followed by the aging process. The reduction of the maximum tensile stress at the stiffened area of the T-type rib was 42% and 50% for the cold pressing and aging, respectively, which increased to 54% and 60% at the smooth area. The mechanism of the stress reduction during the cold pressing and the aging processes was discussed.
The Impact of Obstacle’s Risk in Pedestrian Agent’s Local Path-Planning
Authors: Trinh Thanh-Trung , Kimura Masaomi
Published: June 2021

While the risk from the obstacle could significantly alter the navigation path of a pedestrian, this problem is often disregarded by many studies in pedestrian simulation, or is hindered by a simplistic simulation approach. To address this problem, we proposed a novel simulation model for the local path-planning process of the pedestrian agent, adopting reinforcement learning to replicate the navigation path. We also addressed the problem of assessing the obstacle’s risk by determining its probability of collision with the obstacle, combining with the danger from the obstacle. This process is subsequently incorporated with our prediction model to provide an accurate navigation path similar to the human thinking process. Our proposed model’s implementation demonstrates a more favorable result than other simulation models, especially in the case of the obstacle’s appearance. The pedestrian agent is capable of assessing the risk from the obstacle in different situations and adapting the navigation path correspondingly.
Parametric Analysis on Landing Gear Strut Friction of Light Aircraft for Touchdown Performance
Authors: Gan Shengyong , Fang Xingbo , Wei Xiaohui
Published: June 2021

The aim of this paper is to obtain the strut friction–touchdown performance relation for designing the parameters involving the strut friction of the landing gear in a light aircraft. The numerical model of the landing gear is validated by drop test of single half-axle landing gear, which is used to obtain the energy absorption properties of strut friction in the landing process. Parametric studies are conducted using the response surface method. Based on the design of the experiment results and response surface functions, the sensitivity analysis of the design variables is implemented. Furthermore, a multi-objective optimization is carried out for good touchdown performance. The results show that the proportion of energy absorption of friction load accounts for more than 35% of the total landing impact energy. The response surface model characterizes well for the landing response, with a minimum fitting accuracy of 99.52%. The most sensitive variables for the four landing responses are the lower bearing width and the wheel moment of inertia. Moreover, the max overloading of sprung mass in LC-1 decreases by 4.84% after design optimization, which illustrates that the method of analysis and optimization on the strut friction of landing gear is efficient for improving the aircraft touchdown performance.
An Energy-Based Discrete Element Modeling Method Coupled with Time-Series Analysis for Investigating Deformations and Failures of Jointed Rock Slopes
Authors: Zhang Xiaona , Mei Gang , Xi Ning , Liu Ziyang , Lin Ruoshen
Published: June 2021

The discrete element method (DEM) can be effectively used in investigations of the deformations and failures of jointed rock slopes. However, when to appropriately terminate the DEM iterative process is not clear. Recently, a displacement-based discrete element modeling method for jointed rock slopes was proposed to determine when the DEM iterative process is terminated, and it considers displacements that come from rock blocks located near the potential sliding surface that needs to be determined before the DEM modeling. In this paper, an energy-based discrete element modeling method combined with time-series analysis is proposed to investigate the deformations and failures of jointed rock slopes. The proposed method defines an energy-based criterion to determine when to terminate the DEM iterative process in analyzing the deformations and failures of jointed rock slopes. The novelty of the proposed energy-based method is that, it is more applicable than the displacement-based method because it does not need to determine the position of the potential sliding surface before DEM modeling. The proposed energy-based method is a generalized form of the displacement-based discrete element modeling method, and the proposed method considers not only the displacement of each block but also the weight of each block. Moreover, the computational cost of the proposed method is approximately the same as that of the displacement-based discrete element modeling method. To validate that the proposed energy-based method is effective, the proposed method is used to analyze a simple jointed rock slope; the result is compared to that achieved by using the displacement-based method, and the comparative results are basically consistent. The proposed energy-based method can be commonly used to analyze the deformations and failures of general rock slopes where it is difficult to determine the obvious potential sliding surface.
Improving Quality in the Process of Hot Rolling of Steel Sheets
Authors: Markulik Stefan , Nagyova Anna , Turisova Renata , Villinsky Tomas
Published: June 2021

The hot rolling of steel sheets is a highly energy-intensive process. There are technical and operational issues associated with this process, and the causes of these issues can be various. This study involved analysis of one issue that has a great influence on the resulting surface quality of rolled sheet metal: rolled foreign material. After the sheet cools, rolled foreign material tends to fall off and a hole then remain on the surface of the sheet. This paper focuses on the search for the root causes of the occurrence of foreign material rolling. The basic categorization of the causes of this issue was performed by experienced long-term operators. The 4M method (man, machine, method, and material) was used to categorize the causes. Pairwise comparison was used to verify the result. Using energy dispersive spectroscopy analysis, the origin of the foreign material was identified. The analysis confirmed that the foreign material was not derived from the primary material. Further research showed that the cause of the issue was the guide rulers, which are a structural part of the rolling mill. Measures were taken to significantly reduce the incidence of the problem, which also had the effect of reducing financial losses, which fell by a third in 18 weeks. In the future, it will be necessary to make design changes (modernization of the rolling mill), which will, however, require more financial investment.
Unit Commitment with Ancillary Services in a Day-Ahead Power Market
Authors: Lin Whei-Min , Yang Chung-Yuen , Tsai Ming-Tang , Wang Yun-Hai
Published: June 2021

This paper integrates Discrete Particle Swarm Optimization (DPSO) and Sequential Quadratic Programming (SQP) to propose a DPSO-SQP method for solving unit commitment problems for ancillary services. Through analysis of ancillary services, including Automatic Generation Control (AGC), Real Spinning Reserve (RSR), and Supplemental Reserve (SR), the cost model of unit commitment was developed. With the requirements of energy balance, ancillary services, and operating constraints considered, DPSO-PSO was used to calculate the energy supply of each source, including the associated AGC, RSR, and SR, and the operating cost of a day-ahead power market was calculated. A study case using the real data from thermal units of Taipower Company (TPC) and Independent Power Producers (IPPs) demonstrated effective results for the “summer” and “non-summer” seasons, as classified by TPC for the two charging rates. According to the test cases in this research, costs without ancillary services in non-summer and summer seasons are higher than those with ancillary services. The simulation results are also compared with the Genetic Algorithm (GA), Evolutionary Programming (EP), Particle Swarm Optimization (PSO), and Simulated Annealing (SA). DPSO-PSO shows effectiveness in solving unit commitment problems with enhanced sorting efficiency, and a higher probability of reaching the global optimum.
An Item Retrieval Algorithm in Flexible High-Density Puzzle Storage Systems
Authors: Shirazi Ehsan , Zolghadr Mohammad
Published: June 2021

This paper studies a design of a puzzle-based storage system. We developed an item retrieval algorithm for our system which has three advantages over the previous counterparts in the literature: (i) we can retrieve items from all sides of our storage system; (ii) the existence of only one empty cell in our system is sufficient to retrieve an item; and (iii) our algorithm never ends in deadlocks. The main feature of our algorithm is to prefer three moves to five moves in the process of moving the seized empty cell toward the optimal side of the requested item. The conventional view in the literature assumes that increasing the number of empty cells always reduces the number of movements required for retrieving items; however, our simulation results show that depending on the size of the puzzle and the number of the requested items, increasing empty cells might make the retrieval process more complicated.
Beer Polyphenols—Bitterness, Astringency, and Off-Flavors
Authors: Habschied Kristina , Košir Iztok Jože , Krstanović Vinko , Kumrić Goran , Mastanjević Krešimir
Published: June 2021

The acceptance of beer among consumers is most influenced by the taste and aroma. Polyphenols are widely responsible for both. Whereas polyphenols do not always result in a positive flavor and taste, they can surely impart certain off-flavors, which will be mentioned in this paper. However, the aftertaste is an important component of the beer-tasting experience and acceptance. The aftertaste, including astringency, may largely influence consumers’ consumption preference and behavior. Bitterness is one of the main, desirable characteristics of beer, but to an untrained consumer, it can often be mistaken with astringency. This review aims to describe the differences between these two properties. Both attributes derive from the same beer components, polyphenols from barley and hop, but there is a distinctive difference between them. To understand the complexity of bitterness and astringency, polyphenols behavior, characteristics, and stability during the brewing process are also described in this review.
Analysis and Forecasting Incidence, Intensive Care Unit Admissions, and Projected Mortality Attributable to COVID-19 in Portugal, the UK, Germany, Italy, and France: Predictions for 4 Weeks Ahead
Authors: Carvalho Kathleen , Vicente João Paulo , Jakovljevic Mihajlo , Teixeira João Paulo Ramos
Published: June 2021

The use of artificial neural networks (ANNs) is a great contribution to medical studies since the application of forecasting concepts allows for the analysis of future diseases propagation. In this context, this paper presents a study of the new coronavirus SARS-COV-2 with a focus on verifying the virus propagation associated with mitigation procedures and massive vaccination campaigns. There were two proposed methodologies in making predictions 28 days ahead for the number of new cases, deaths, and ICU patients of five European countries: Portugal, France, Italy, the United Kingdom, and Germany. A case study of the results of massive immunization in Israel was also considered. The data input of cases, deaths, and daily ICU patients was normalized to reduce discrepant numbers due to the countries’ size and the cumulative vaccination values by the percentage of population immunized (with at least one dose of the vaccine). As a comparative criterion, the calculation of the mean absolute error (MAE) of all predictions presents the best methodology, targeting other possibilities of use for the method proposed. The best architecture achieved a general MAE for the 1-to-28-day ahead forecast, which is lower than 30 cases, 0.6 deaths, and 2.5 ICU patients per million people.
Intra-Operative Video-Based Measurement of Biaxial Strains of the Ascending Thoracic Aorta
Authors: Parikh Shaiv , Ganizada Berta , Debeij Gijs , Natour Ehsan , Maessen Jos , Spronck Bart , Schurgers Leon , Delhaas Tammo , Huberts Wouter , Bidar Elham , Reesink Koen
Published: June 2021

Local biaxial deformation measurements are essential for the in-depth investigation of tissue properties and remodeling of the ascending thoracic aorta, particularly in aneurysm formation. Current clinical imaging modalities pose limitations around the resolution and tracking of anatomical markers. We evaluated a new intra-operative video-based method to assess local biaxial strains of the ascending thoracic aorta. In 30 patients undergoing open-chest surgery, we obtained repeated biaxial strain measurements, at low- and high-pressure conditions. Precision was very acceptable, with coefficients of variation for biaxial strains remaining below 20%. With our four-marker arrangement, we were able to detect significant local differences in the longitudinal strain as well as in circumferential strain. Overall, the magnitude of strains we obtained (range: 0.02–0.05) was in line with previous reports using other modalities. The proposed method enables the assessment of local aortic biaxial strains and may enable new, clinically informed mechanistic studies using biomechanical modeling as well as mechanobiological profiling.
Low Hemoglobin-to-Red Cell Distribution Width Ratio Is Associated with Disease Progression and Poor Prognosis in Upper Tract Urothelial Carcinoma
Authors: Su Yung-Chun , Wen Sheng-Chen , Li Ching-Chia , Su Hsiao-Chun , Ke Hung-Lung , Li Wei-Ming , Lee Hsiang-Ying , Li Chia-Yang , Yang Sheau-Fang , Tu Hung-Pin , Wu Wen-Jeng , Yeh Hsin-Chih
Published: June 2021

The importance of blood cell markers in patients with malignant tumors has been studied, but there are few studies on the prognostic value of hemoglobin-to-red cell distribution width ratio (HRR) in cancer. This is the first study to investigate the effect of preoperative HRR on patients with upper tract urothelial carcinoma (UTUC). Our retrospective cohort study included 730 UTUC patients who underwent nephroureterectomy from 2000 to 2019. Clinicopathological parameters were compared according to HRR levels, and the relationship between blood cell markers (HRR, white blood cell [WBC] count, platelet count) and prognosis was evaluated using Kaplan–Meier method and Cox regression model. We found that patients with HRR ≤ 1.05 tended to have worse renal function, higher pathological stages, and more high-grade tumors. In univariate analysis, HRR ≤ 1.05, WBC > 8.65 × 103 cells/μL and platelets >309 × 103 cells/μL were associated with poor progression-free survival (PFS), cancer-specific survival (CSS), and overall survival (OS). Multivariate analysis demonstrated that HRR ≤ 1.05 and WBC > 8.65 × 103 cells/μL were independent prognostic factors for predicting deterioration of PFS, CSS, and OS. In conclusion, HRR and WBC are easy to obtain in clinical practice and are useful indicators to provide prognostic information before surgery for UTUC.
Autistic Traits and Attention-Deficit Hyperactivity Disorder Symptoms Predict the Severity of Internet Gaming Disorder in an Italian Adult Population
Authors: Concerto Carmen , Rodolico Alessandro , Avanzato Chiara , Fusar-Poli Laura , Signorelli Maria Salvina , Battaglia Fortunato , Aguglia Eugenio
Published: June 2021

Over the last decade, internet gaming has been a fast-growing recreational activity. Gamers risk their leisure activity becoming an addiction. In the present study, we aimed to measure the prevalence of Internet Gaming Disorder (IGD) in an adult population of video game players and to investigate the association between demographic variables, Autism Spectrum Disorder (ASD) traits, Attention-Deficit Hyperactivity Disorder (ADHD) severity, and IGD in adults. Through an online survey, we recruited 4260 individuals aged between 18 and 55 years old, who were members of online communities of video gamers. We collected demographic data and administered three questionnaires: the Internet Gaming Disorder Scale-Short Form (IGD9-SF), the Autism Spectrum Quotient (AQ), and the Adult ADHD Self-Report Scale (ASRS). Of the overall sample, 29.67% scored above the cut-off of 21 points for the IGD9-SF. Multiple linear regression models showed that daily spare time, autistic traits, and ADHD symptoms were positively associated with the severity of IGD in adults, after controlling for demographic variables. Future studies are required in order to explore factors linked to IGD in adults.
Neurosonological Findings Related to Non-Motor Features of Parkinson’s Disease: A Systematic Review
Authors: del Toro Pérez Cristina , Amaya Pascasio Laura , Arjona Padillo Antonio , Olivares Romero Jesús , Mejías Olmedo María , Fernández Pérez Javier , Payán Ortiz Manuel , Martínez-Sánchez Patricia
Published: June 2021

Non-motor symptoms (NMS) in Parkinson’s disease (PD), including neuropsychiatric or dysautonomic complaints, fatigue, or pain, are frequent and have a high impact on the patient’s quality of life. They are often poorly recognized and inadequately treated. In the recent years, the growing awareness of NMS has favored the development of techniques that complement the clinician’s diagnosis. This review provides an overview of the most important ultrasonographic findings related to the presence of various NMS. Literature research was conducted in PubMed, Scopus, and Web of Science from inception until January 2021, retrieving 23 prospective observational studies evaluating transcranial and cervical ultrasound in depression, dementia, dysautonomic symptoms, psychosis, and restless leg syndrome. Overall, the eligible articles showed good or fair quality according to the QUADAS-2 assessment. Brainstem raphe hypoechogenicity was related to the presence of depression in PD and also in depressed patients without PD, as well as to overactive bladder. Substantia nigra hyperechogenicity was frequent in patients with visual hallucinations, and larger intracranial ventricles correlated with dementia. Evaluation of the vagus nerve showed contradictory findings. The results of this systematic review demonstrated that transcranial ultrasound can be a useful complementary tool in the evaluation of NMS in PD.