bluuebunny/crossref_metadata_2025 huggingface dataset:
Bi-stable spin-crossover characteristics of a highly distorted [Fe(1-BPP-COOC2H5)2](ClO4)2·CH3CN complex
Authors: Senthil Kumar Kuppusamy , Heinrich Benoît , Vela Sergi , Moreno-Pineda Eufemio , Bailly Corinne , Ruben Mario
Published: February 2019

A HS Fe(ii) complex, see figure, with a pronounced angular distortion (ϕ) = 158.83(17)° showed lattice solvent dependent spin-state switching characteristics with a thermal hysteresis width (ΔT) of 101 K.
Fabrication of blue organic light-emitting diodes from novel uranium complexes: synthesis, characterization, and electroluminescence studies of uranium anthracene-9-carboxylate complexes
Authors: Darzinezhad Khodabakhsh , Amini Mostafa M. , Mohajerani Ezeddin , Armaghan Mahsa , Knedel Tim Oliver , Abareghi Afshin , Janiak Christoph
Published: February 2019

The optical properties of the prepared complexes are associated with the aromatic ligand resonant system.
Synthesis and magnetic studies of pentagonal bipyramidal metal complexes of Fe, Co and Ni
Authors: Deng Yi-Fei , Yao Binling , Zhan Peng-Zhi , Gan Dexuan , Zhang Yuan-Zhu , Dunbar Kim R.
Published: February 2019

Three mononuclear model complexes with pentagonal bipyramidal geometry, [MII(L-N3O2)(MeCN)2][BPh4]2 (M = Fe, 1; Co, 2; Ni, 3) were isolated and found to exhibit large uniaxial (1 and 3) and easy-plane (2) magnetic anisotropy, respectively.
Highly efficient potassium fertilizer production by using a gemini surfactant
Authors: Huang Zhiqiang , Cheng Chen , Liu Zuwen , Feng Bo , Hu Yajing , Luo Wuhui , He Guichun , Yu Xinyang , Fu Weng
Published: February 2019

A gemini surfactant as a collector for froth flotation separation of KCl from NaCl to produce potassium fertilizer.
Synthesis, characterization, and water-degradation of biorenewable polyesters derived from natural camphoric acid
Authors: Nsengiyumva Olivier , Miller Stephen A.
Published: February 2019

Sugar-derived diols are copolymerized with terpene-derived camphoric acid to yield polyesters with high glass transition temperatures and an unusual susceptibility to hydrolytic degradation.
In situ visualization of hydrophilic spatial heterogeneity inside microfluidic chips by fluorescence microscopy
Authors: Tian Rui , Li Kaitao , Shi Wenying , Ding Caifeng , Lu Chao
Published: February 2019

We demonstrate in situ visualization of hydrophilic heterogeneity inside microfluidic chips using aggregation-induced emission molecules to label the hydroxyl groups.
Two-dimensional arrays self-assembledviainterference of concentration modulation waves in drying solutions
Authors: Li Shunpu , Chun Young Tea , Li Jin , Shrestha Pawan , Ahn Hyungju , Ahn Docheon , Sohn Jung Inn , Hong Woong-Ki , Kim Bongjun , Deng Yuanbo , Chu Daping
Published: February 2019

Self-assembly of patterned nanostructures in solution-processed thin films with single phase polymers is successful.
Recent advances in developing high-performance nanostructured electrocatalysts based on 3d transition metal elements
Authors: Wan Hao , Liu Xiaohe , Wang Haidong , Ma Renzhi , Sasaki Takayoshi
Published: February 2019

Versitle strategies for devoloping high-performance nanostructured electrocatalysts based on 3d transition metal elements have been reviewed.
Graphene-induced hierarchical mesoporous MgO for the Claisen–Schmidt condensation reaction
Authors: Qi Xiaoxia , Yan Xirui , Peng Wencai , Zhang Jianshu , Tong Yanbin , Li Jun , Sun Dekui , Hui Ge , Zhang Jinli
Published: February 2019

Multistage mesoporous magnesium oxide prepared by a simple hydrothermal method has an ideal particle size, channel distribution, active crystal face, good catalytic activity and regeneration ability.
MOF-derived CeO2/Au@SiO2 hollow nanotubes and their catalytic activity toward 4-nitrophenol reduction
Authors: Zhang Zewu , Shi Haojun , Wu Qiong , Bu Xiaohai , Yang Yunfeng , Zhang Jie , Huang Yue
Published: February 2019

A hollow CeO2/Au@SiO2 sandwiched nanocatalyst with enhanced catalytic activity was prepared by using Ce-MOF as a sacrificial template.
Synthesis of 3,5-ditetrazolyl-1,2,4-triazole-based complexes: a strategy for developing C–N-linked triheterocyclic energetic compounds
Authors: Wu Le , He Piao , Li Zhimin , Wang Qianyou , Yang Junqing , Sinditskii Valery P. , Zhang Jian-Guo
Published: February 2019

Two complexes based on the novel C–N-linked triheterocyclic compound 3,5-ditetrazolyl-1,2,4-triazole (DTT) were reported for the first time. The present study has contributed to the field of C–N-linked polyheterocyclic systems and has provided a new insight into the design and synthesis of new energetic materials.
Au@Pt nanodendrites enhanced multimodal enzyme-linked immunosorbent assay
Authors: Jiao Lei , Zhang Lianhua , Du Wenwen , Li He , Yang Dingyu , Zhu Chengzhou
Published: February 2019

Single modal enzyme-linked immunosorbent assay (ELISA) covering colorimetric, fluorescence, and chemiluminescence techniques has been widely reported in recent years, whereas the combination of multiple signal channels in one immunosensing platform still faces huge challenges.
Large area metal micro-/nano-groove arrays with both structural color and anisotropic wetting fabricated by one-step focused laser interference lithography
Authors: Wu Hao , Jiao Yunlong , Zhang Chenchu , Chen Chao , Yang Liang , Li Jiawen , Ni Jincheng , Zhang Yachao , Li Chuanzong , Zhang Yiyuan , Jiang Shaojun , Zhu Suwan , Hu Yanlei , Wu Dong , Chu Jiaru
Published: February 2019

Colorful and anisotropic multi-functional metal surfaces fabricated by focused laser interference lithography.
Maturation of adenovirus primes the protein nano-shell for successful endosomal escape
Authors: Denning D. , Bennett S. , Mullen T. , Moyer C. , Vorselen D. , Wuite G. J. L. , Nemerow G. , Roos W. H.
Published: February 2019

The ability of adenoviruses to infect a broad range of species has spurred a growing interest in nanomedicine to use adenovirus as a cargo delivery vehicle.
Fe3O4nanoparticle decorated three-dimensional porous carbon/MoS2composites as anodes for high performance lithium-ion batteries
Authors: Jeon Youngmoo , Lee Jeongyeon , Kim Myungjin , Oh Jiseop , Hwang Taejin , Piao Yuanzhe
Published: February 2019

3D porous carbon/MoS2composites with Fe3O4nanoparticles (C-MF) were synthesized and utilized as anodes for high performance lithium-ion batteries.
The design of Janus black phosphorus quantum dots@metal–organic nanoparticles for simultaneously enhancing environmental stability and photodynamic therapy efficiency
Authors: Zhang Da , Lin Ziguo , Lan Shanyou , Sun Haiyan , Zeng Yongyi , Liu Xiaolong
Published: February 2019

We have fabricated Janus nanoparticles based on black phosphorus quantum dots and metal–organic particles for PDT enhancement.
Mechanism and modeling of hexavalent chromium interaction with a typical black soil: the importance of the relationship between adsorption and reduction
Authors: Zhang Jia , Yin Huilin , Barnie Samuel , Wei Minghai , Chen Honghan
Published: February 2019

A novel two-step kinetic model was developed based on the proposed “adsorption–reduction” mechanism of Cr(vi) retention by a typical black soil.
Lipase-catalyzed synthesis of red pitaya (Hylocereus polyrhizus) seed oil esters for cosmeceutical applications: process optimization using response surface methodology
Authors: Abdullah Asiah , Abd Gani Siti Salwa , Yun Hin Taufiq Yap , Haiyee Zaibunnisa Abdul , Zaidan Uswatun Hasanah , Kassim Mohd Azlan , Effendi Halmi Mohd Izuan
Published: February 2019

Optimization of the alcoholysis reaction between red pitaya seed oil and oleyl alcohol catalyzed by Lipozyme RM IM was carried out.
Fabrication and characterization of electrospun PLLA/PANI/TSA fibers
Authors: Yao Junyan , Chen Yifu , Li Wudan , Chen Xiao , Fan Xiaodong
Published: February 2019

Poly(l-lactic acid)/polyaniline/TSA (PLLA/PANI/TSA) fiber mats play a positive role as a tissue scaffold for osteoblast cell proliferation.
Radical theory of hydride atomization confirmed after four decades – determination of H radicals in a quartz hydride atomizer by two-photon absorption laser-induced fluorescence
Authors: Dvořák Pavel , Talába Marek , Kratzer Jan , Dědina Jiří
Published: February 2019

The knowledge of hydrogen radical distribution opens a way to an elegant and straightforward optimization of hydride atomizers.
An aluminum(iii) picket fence phthalocyanine-based heterogeneous catalyst for ring-expansion carbonylation of epoxides
Authors: Jiang Jianwei , Yoon Sungho
Published: February 2019

An effective heterogeneous catalyst for ring-expansion carbonylation of epoxides may have additional advantages over the homogeneous counterpart in terms of facile product separation and recyclability.
Bi-functional additive engineering for high-performance perovskite solar cells with reduced trap density
Authors: Yang Yi , Peng Huirong , Liu Cheng , Arain Zulqarnain , Ding Yong , Ma Shuang , Liu Xiaolong , Hayat Tasawar , Alsaedi Ahmed , Dai Songyuan
Published: February 2019

The bi-functional additive of ammonium benzenesulfonate enables the fabrication of low-defect and high-performance perovskite solar cells.
Emission enhancement and bandgap retention of a two-dimensional mixed cation lead halide perovskite under high pressure
Authors: Chen Yaping , Fu Ruijing , Wang Lingrui , Ma Zhiwei , Xiao Guanjun , Wang Kai , Zou Bo
Published: February 2019

The pressure response of (C(NH2)3)(CH3NH3)2Pb2I7 is significant along with phenomenal emission enhancement and bandgap retention for investigating the structure–property relationships.
An ultrathin cobalt–iron oxide catalyst for water oxidation on nanostructured hematite photoanodes
Authors: Liardet Laurent , Katz Jordan E. , Luo Jingshan , Grätzel Michael , Hu Xile
Published: February 2019

An optically transparent cobalt-iron oxide catalyst improves the photoelectrochemical performance of nanostructured hematite photoanodes.
Co–Cu–WSx ball-in-ball nanospheres as high-performance Pt-free bifunctional catalysts in efficient dye-sensitized solar cells and alkaline hydrogen evolution
Authors: Qian Xing , Liu Hongyu , Yang Jiahui , Wang Huiwen , Huang Jie , Xu Chong
Published: February 2019

Co–Cu–WSx ball-in-ball nanospheres have been synthesized and used as highly efficient bifunctional electrocatalysts for both DSSCs and the HER.
Emerging biomedical applications of polyaspartic acid-derived biodegradable polyelectrolytes and polyelectrolyte complexes
Authors: Yavvari Prabhu Srinivas , Awasthi Anand Kumar , Sharma Aashish , Bajaj Avinash , Srivastava Aasheesh
Published: February 2019

A summary of positive biomedical attributes of biodegradable polyelectrolytes (PELs) prepared from aspartic acid is provided. The utility of these PELs in emerging applications such as biomineralization modulators, antimycobacterials, biocompatible cell encapsulants and tissue adhesives is highlighted.
Unique elastic, dielectric and piezoelectric properties of micro-architected metamaterials
Authors: Shu Longlong , Liang Renhong , Yu Yanzhuo , Tian Tingfang , Rao Zhenggang , Wang Yu
Published: February 2019

Complex micro-architectured metamaterials exhibit unique elastic and dielectric properties as well as ultrahigh piezoelectric responses.
Ambipolar transistors based on chloro-substituted tetraphenylpentacene
Authors: Sato Ryonosuke , Eda Shohei , Sugiyama Haruki , Uekusa Hidehiro , Hamura Toshiyuki , Mori Takehiko
Published: February 2019

Transistor properties of halogen-substituted tetraphenylpentacenes sensitively change depending on the slip distance along the molecular long axis.
Biocompatible Ag2S quantum dots for highly sensitive detection of copper ions
Authors: Jiang Peng , Li Shulan , Han Minlu , Liu Yi , Chen Zilin
Published: February 2019

An Ag2S QD fluorescent sensor for highly selective and sensitive Cu2+ detection was developed and the quenching mechanism was investigated.
Ultralong circulating choline phosphate liposomal nanomedicines for cascaded chemo-radiotherapy
Authors: Li Xiaoqiu , Zhao Yangyang , Jiang Wei , Li Shuya , Zhan Meixiao , Liu Hao , Zhang Congjun , Liang Hui , Liu Hang , Lu Ligong , Wang Yucai
Published: February 2019

Vorinostat-sensitized radiotherapy aggravates hypoxia and then activates AQ4N to kill radiotherapy-tolerating hypoxic cells and achieve the synergism of cascaded chemo-radiotherapy.
Unusual ligand rearrangement: from N-phosphinoguanidinato to phosphinimine-amidinato compounds
Authors: Fernández-Galán Rafael , Ramos Alberto , Huergo Estefanía , Antiñolo Antonio , Carrillo-Hermosilla Fernando , Rodríguez-Diéguez Antonio , García-Vivó Daniel
Published: February 2019

N,N′-Phosphinoguanidinate Al compounds rearrange under mild conditions to phosphinimine-amidinato derivatives via an unprecedented carbodiimide de-insertion followed by [3+2] cycloaddition.
Controlled α-mono- and α,α-di-halogenation of alkyl sulfones using reagent–solvent halogen bonding
Authors: Poteat Christopher M. , Lindsay Vincent N. G.
Published: February 2019

The direct and selective α-halogenation of alkyl sulfones was achieved via base-mediated electrophilic halogenation, where reagent–solvent halogen bonding was found to control the selectivity through alteration of the effective size of the halogen source.
A reversible ion transportation switch of ON–OFF–ON type by a ligand-gated calix[6]arene channel
Authors: Hu Xinyu , Liu Nannan , Yang Haishen , Wu Fen , Chen Xi , Li Canpeng , Chen Xiaojing
Published: February 2019

Calix[6]arene (CX6) was found to be an efficient ion transmembrane channel, which could be blocked by methylene blue (MB) through host–guest interactions.
A luminescent sensor based on a Zn(ii) coordination polymer for selective and sensitive detection of NACs and Fe3+ ions
Authors: Zhang Xiao , Zhuang Xinrui , Zhang Nanxi , Ge Chunyu , Luo Xuan , Li Jinxue , Wu Jie , Yang Qingfeng , Liu Rui
Published: February 2019

To design an effective fluorescence probe for sensing nitroaromatic compounds and metal ions, a novel two-dimensional coordination polymer, {Zn2(NO3)2(4,4′-bpy)2(TBA)}, was synthesized via a hydrothermal method.
Solvent-free anhydrous Li+, Na+ and K+ salts of [B(3,5-(CF3)2C6H3)4]−, [BArF4]−. Improved synthesis and solid-state structures
Authors: Martínez-Martínez Antonio J. , Weller Andrew S.
Published: February 2019

We report an alternative, improved, multigram scale (∼20 g, 60–70% yield) preparation of solvent-free anhydrous Li[BArF4], Na[BArF4] and K[BArF4], and the corresponding single-crystal X-ray characterisation of [Li(H2O)][BArF4], Na[BArF4]˙ and K[BArF4].
Electrochemical investigation of uncapped AgBiS2 (schapbachite) synthesized using in situ melts of xanthate precursors
Authors: Khan Malik Dilshad , Aamir Muhammad , Sohail Manzar , Bhoyate Sanket , Hyatt Megan , Gupta Ram K. , Sher Muhammad , Revaprasadu Neerish
Published: February 2019

In this study, a facile and potentially scalable synthesis of AgBiS2 (schapbachite) using melts of metal xanthates is presented; AgBiS2 is both a significant mineral and a technologically important material.
Organic–inorganic hybrids assembled from plenary Keggin-type germanotungstate units and 3d–4f heterometal clusters
Authors: Li Huijie , Gong Peijun , Jiang Jun , Li Yamin , Pang Jingjing , Chen Lijuan , Zhao Junwei
Published: February 2019

Two kinds of 3d–4f heterometal plenary Keggin germanotungstates were prepared. Their electrochemical sensing properties towards Acetaminophen detection were investigated.
A platinum(iv) prodrug to defeat breast cancer through disrupting vasculature and inhibiting metastasis
Authors: Guo Yan , Zhang Shuren , Yuan Hao , Song Dongfan , Jin Suxing , Guo Zijian , Wang Xiaoyong
Published: February 2019

A PtIV prodrug bearing a vascular disrupting agent demonstrates antiangiogenic and antimetastatic potentialities against metastatic triple-negative breast cancer cells.
Correction: Au@PdOx with a PdOx-rich shell and Au-rich core embedded in Co3O4 nanorods for catalytic combustion of methane
Authors: Yang Nating , Liu Jingwei , Sun Yuhan , Zhu Yan
Published: February 2019

Correction for ‘Au@PdOx with a PdOx-rich shell and Au-rich core embedded in Co3O4 nanorods for catalytic combustion of methane’ by Yan Zhu et al., Nanoscale, 2017, 9, 2123–2128.
Stereocontrol in the synthesis of cyclic amino acids: a new ligand for directed hydrogenation through hydrogen bonding
Authors: Gandi Vasudeva Rao , Doan Bao Nguyen Do , Kasinathan Sivarajan , Bates Roderick W.
Published: February 2019

Directed hydrogenation of the nitrogen heterocycles is enhanced by hydrogen bonding between the substrate alcohol group and the ligand methoxy group.
Modular DNA-based hybrid catalysts as a toolbox for enantioselective hydration of α,β-unsaturated ketones
Authors: Yum Ji Hye , Park Soyoung , Hiraga Ryota , Okamura Izumi , Notsu Shunta , Sugiyama Hiroshi
Published: February 2019

The direct addition of water to a carbon–carbon double bond remains a challenge, but such a reaction is essential for the development of efficient catalysts that enable direct access to chiral alcohols.
Biosynthetic studies of novel polyketides from the marine sponge-derived fungusStachylidiumsp. 293K04
Authors: El Maddah Fayrouz , Eguereva Ekaterina , Kehraus Stefan , König Gabriele M.
Published: February 2019

A methylation of the acetate starter unit is part of the polyketide biosynthesis of phthalides and phthalimidines from the marine-derived fungusStachylidiumsp. 293K04.
Visible light enabled γ-trifluoromethylation of Baylis–Hillman acetates: stereoselective synthesis of trisubstituted alkenes
Authors: Yadav Arvind Kumar , Sharma Anup Kumar , Singh Krishna Nand
Published: February 2019

Metal-free γ-trifluoromethylation of Baylis–Hillman acetates is reported using Langlois’ reagent under visible light photoredox catalysis.
Quantitative determination of the spring entropy effect and its indication of the conformational change of polymer coils with varying concentration in aqueous poly(N-isopropylamide) solutions
Authors: Song Li , Lin Jiaxiang , Liu Panpan , Li Jingqing , Jiang Shichun , Huang Dinghai
Published: February 2019

Entropy effect is deduced from the distinctive demixing enthalpy behavior in different concentration regions of PNIPAM aqueous solution and interpretated as the conformational change of polymer coil.
Luminescent switching and structural transition through multiple external stimuli based on organic molecular polymorphs
Authors: Shao Bo , Jin Rihua , Li Aisen , Liu Yingjie , Li Bao , Xu Shuping , Xu Weiqing , Xu Bin , Tian Wenjing
Published: February 2019

Investigations on the relationship between multi-stimuli responsive luminescent properties and aggregation structures of polymorphs play a crucial role in developing organic multi-stimuli responsive luminescent (OMSRL) materials.
LHC-like proteins involved in stress responses and biogenesis/repair of the photosynthetic apparatus
Authors: Rochaix Jean-David , Bassi Roberto
Published: February 2019

LHC (light-harvesting complex) proteins of plants and algae are known to be involved both in collecting light energy for driving the primary photochemical reactions of photosynthesis and in photoprotection when the absorbed light energy exceeds the capacity of the photosynthetic apparatus. These proteins usually contain three transmembrane (TM) helices which span the thylakoid membranes and bind several chlorophyll, carotenoid and lipid molecules. In addition, the LHC protein family includes LHC-like proteins containing one, two, three or even four TM domains. One-helix proteins are not only present in eukaryotic photosynthetic organisms but also in cyanobacteria where they have been named high light-inducible proteins. These small proteins are probably the ancestors of the members of the extant LHC protein family which arouse through gene duplications, deletions and fusions. During evolution, some of these proteins have diverged and acquired novel functions. In most cases, LHC-like proteins are induced in response to various stress conditions including high light, high salinity, elevated temperature and nutrient limitation. Many of these proteins play key roles in photoprotection, notably in non-photochemical quenching of absorbed light energy. Moreover, some of these proteins appear to be involved in the regulation of chlorophyll synthesis and in the assembly and repair of Photosystem II and also of Photosystem I possibly by mediating the insertion of newly synthesized pigments into the photosynthetic reaction centers.
The value of Cone-Beam CT-guided radiofrequency ablation in the treatment of pulmonary malignancies (≤3 cm)
Authors: Xiang Zi-jun , Wang Yi , Du En-fu , Xu Lin , Jiang Bin , Li Huili , Wang Yun , Cui Ning
Published: February 2019

The aim of this study is to explore the safety and efficacy of Cone-Beam computed tomography (CBCT) guided radiofrequency ablation (RFA) in the treatment of pulmonary malignancies. Thirty-one patients with pulmonary malignant tumors (≤3 cm in diameter) were enrolled to this study. Total 43 CBCT guided RFA treatments were performed, including 7 patients undergoing multiple treatments. The target tumor puncture success rate, tumor remission rate, postoperative cumulative survival rate, tumor-free survival rate and complication rate were analyzed. All 43 CBCT guided RFA procedures successfully punctured the target tumors. Complications included five cases of pneumothorax and three cases of hemoptysis. For the 31 patients who underwent CBCT guided RFA, the 1- and 2-year cumulative survival rates were 80.6 and 54.8%, respectively. The 1- and 2-year disease-free survival rates were 54.8 and 32.3%, respectively. The 1-, 3- and 6-month remission rates were 78.4, 68.7 and 63.3%, respectively. The average cumulative radiation dose and average effective radiation dose were 194.62 ± 105.51 mGy and 5.41 ± 3.45 mSv, respectively. CBCT help to shorten the operation time, reduce the unnecessary interventions and also reduce the incidence of complications. CBCT guided RFA is one safe and efficacious treatment for pulmonary malignancies.
Association between ACE gene I/D polymorphism and knee osteoarthritis in a Chinese population
Authors: Chen Genjun , Hu Shengping , Lai Zhen , Qiu Binsong
Published: February 2019

Osteoarthritis (OA) is a degenerative joint disease characterized by joint destruction with cartilage loss and occasional gross derangement of joint integrity. In recent years, several studies have reported the association between angiotensin-converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism and knee OA. However, the results were conflicting. To determine the association between ACE gene I/D polymorphism and knee OA, we conducted a hospital-based case–control study with 282 knee OA cases and 316 controls to investigate the association between ACE gene I/D polymorphism and knee OA susceptibility in a Chinese Han population. The present study found that DD genotype or D allele carriers of ACE gene I/D polymorphism increased the risk of knee OA. Stratification analyses of sex, age, and body mass index (BMI) showed significant associations amongst the groups of females, ≥55 years, and abnormal BMI. In addition, the present study made analysis between ACE I/D polymorphism and some clinical features of OA, and found DD genotype of I/D polymorphism was associated with arthralgia. Furthermore, we undertook a meta-analysis together with the present study between this single nucleotide polymorphism (SNP) and knee OA risk. This meta-analysis found that ACE gene I/D polymorphism was associated with increased risk for OA. Stratification analysis of ethnicity in this meta-analysis indicated that I/D polymorphism increased the risk of knee OA amongst the Asians and Caucasians. In conclusion, this case–control study and meta-analysis suggest that ACE gene I/D polymorphism is associated with increased risk for knee OA.
Overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues predicts poor survival in pancreatic ductal adenocarcinoma
Authors: Dong Shu , Huang Fei , Zhang Hao , Chen Qiwen
Published: February 2019

Overexpressed genes in tumors usually contributed to aggressiveness in pancreatic ductal adenocarcinoma (PDAC). Using Gene Expression Omnibus (GEO) profiles including GSE46234, GSE71989, and GSE107610, we detected overexpressed genes in tumors with R program, which were enriched by Kyoto Encyclopedia of Genes and Genomes (KEGG), Gene ontology (GO), and Reactome pathway databases. Then, we performed a survival analysis of enriched genes based on TCGA profile. Our results revealed that high BUB1B, CCNA2, CDC20, and CDK1 expression in tumors was significantly associated with worse overall survival (OS) (Log rank P=0.00338, P=0.0447, P=0.00965, and P=0.00479, respectively), which was validated using a Kaplan–Meier plotter with a median cutoff (Log rank P=0.028, P=0.0035, P=0.039, and P=0.0033, respectively). Moreover, overexpression of BUB1B, CCNA2, CDC20, and CDK1 in tumor tissues was significantly associated with disease-free survival (DFS) in PDAC patients (Log rank P=0.00565, P=0.0357, P=0.00104, and P=0.00121, respectively). BUB1B, CCNA2, CDC20, and CDK1 were significantly overexpressed in deceased PDAC patients (all P<0.01) and in patients with recurrence/disease progression (all P<0.05). In addition, PDAC patients with neoplasms of histologic grade G3-4 had significantly higher BUB1B, CCNA2 and CDC20 levels (all P<0.05). In conclusion, the up-regulation of BUB1B, CCNA2, CDC20, CDK1, and WEE1 in tumor tissues are associated with worse OS and DFS in PDAC and is correlated with advanced tumor stage and tumor development.
The associations between Toll-like receptor 4 gene polymorphisms and hepatitis C virus infection: a systematic review and meta-analysis
Authors: Chaiwiang Narttaya , Poyomtip Teera
Published: February 2019

Background and objective: The hepatitis C virus (HCV) is able to cause a life-threatening disease relating to lethal hepatocellular carcinoma. Previous, Toll-like receptor polymorphisms were proposed as promising biomarker for HCV-related hepatocellular carcinoma and disease progression. This study aimed to summarize the association of TLR4 polymorphisms and HCV infection through meta-analysis.

Methods: We applied a systematic review and meta-analysis performed by using PubMed, EMBASE and Web of Science searches. The Modified Newcastle-Ottawa scale was used for quality assessment. The odd-ratio (OR) and 95% confidence interval (CI) were calculated to assess the association. In silico analysis was applied for proposing the function as microRNA (miRNA) of non-coding polymorphism. Finally, the miRNA target was predicted and annotated to suggest the possible relationship between polymorphism and HCV infection.

Results: Our meta-analysis incorporated seven studies involving rs4986791, rs4986790 and rs2149356. No association exists between rs4986791 and HCV infection. However, the heterozygous model (AG vs GG) of rs4986790 significantly associates with HCV infection (OR = 0.33, 95% CI = 0.21–0.49, P<0.0001). Moreover, the rs2149356 TG genotype also associates with HCV infection in the over-dominant model (TG vs TT+TG: OR = 0.54, 95% CI = 0.40–0.75). In silico analysis of rs2149356G allele showed that this mutation is siRNA, which targets the set of genes, especially in the autophagy pathway.

Conclusion: We demonstrated that rs4986790 and rs2149356 are associated with HCV infection.
A LOFAR search for steep-spectrum pulsars in supernova remnants and pulsar wind nebulae
Authors: Straal S. M. , van Leeuwen J.
Published: February 2019

Pinpointing a pulsar in its parent supernova remnant (SNR) or resulting pulsar wind nebula (PWN) is key to understanding its formation history and the pulsar wind mechanism, yet only about half the SNRs and PWNe appear associated with a pulsar. Our aim was to find the pulsars in a sample of eight known and new SNRs and PWNe. Using the LOFAR radio telescope at 150 MHz, each source was observed for 3 h. We covered the entire remnants where needed, by employing many tied-array beams to tile out even the largest objects. For objects with a confirmed point source or PWN we constrained our search to those lines of sight. We identified a promising radio pulsar candidate towards PWN G141.2+5.0. The candidate, PSR J0337+61, has a period of 94 ms and a DM of 226 pc cm−3. We re-observed the source twice with increased sensitivities of 30% and 50%, but did not re-detect it. It thus remains unconfirmed. For our other sources we obtain very stringent upper limits of 0.8 − 3.1 mJy at 150 MHz. Generally, we can rule out that the pulsars travelled out of the remnant. From these strict limits we conclude our non-detections towards point sources and PWNe are the result of beaming and propagation effects. Some of the remaining SNRs should host a black hole rather than a neutron star.
The optimal time for sampling macroinvertebrates and its implications for diversity indexing in rheocrenes − case study from the Prokletije Mountains
Authors: Berlajolli Violeta , Płóciennik Mateusz , Antczak-Orlewska Olga , Pešić Vladimir
Published: February 2019

In most studies, sampling of springs has typically been undertaken over one season, which has raised the question what the most suitable time(s) to undertake sampling is. In this study, we report the results of macroinvertebrate monthly samplings performed in two springs in western Kosovo in order to determine the most appropriate time to undertake sampling to characterise biodiversity. Diversity indices have revealed that insect assemblages remain more diverse than assemblages of fully aquatic invertebrates. The results of SIMPER have revealed that winter communities remain the most dissimilar one another and also to other seasons. However, when Gammarus balcanicus is excluded, this pattern becomes blurred. To sum up, our results illustrate that (1) multiple surveys covering more than one season provide a comprehensive picture of total biodiversity, and (2) for appropriate characterising of the macroinvertebrate community in the studied rheocrenes at least winter and summer were required.
Les parcours de prévention par le sport de l’obésité chez les enfants d’un quartier populaire strasbourgeois : transmissions familiales et rapports à l’activité physique
Authors: Grassler Marine , Knobé Sandrine , Gasparini William
Published: February 2019

Depuis 2014, la ville de Strasbourg a mis en place un parcours de prévention intitulé « PRise En Charge Coordonnée des enfants Obèses et en Surpoids de Strasbourg » (PRECCOSS) destiné aux enfants âgés de 3 à 12 ans. Les enfants en situation de surpoids ou d’obésité bénéficient ainsi d’une prise en charge gratuite d’une durée de trois ans avec un suivi individuel et des ateliers collectifs d’activité physique. Dans cette tranche d’âge, la famille joue un rôle important d’accompagnement ou d’incitation mais également de transmission de comportements actifs selon différentes modalités et stratégies, conscientes et inconscientes. L’analyse des transmissions du « goût » à l’activité physique à partir d’une enquête qualitative auprès d’enfants en surpoids et de leurs parents résidant dans un quartier populaire permet d’identifier des logiques familiales différenciées où se conjuguent effet des trajectoires sociales et division sexuée des rôles parentaux.
Outcomes of use of electromagnetic guidance with responsive insertion technology (RIT) during colonoscopy: a prospective randomized controlled trial
Authors: Peter Shajan , Reddy Nipun , Naseemuddin Mohammed , Zaibaq Jenine , McGwin Gerald , Wilcox C.
Published: February 2019

Background and study aims Colonoscopy can be technically challenging and cause discomfort in patients. The integrated Scope Guide assist is built in to show that with its use outcomes are improved during colonoscopy. We aimed to test the usefulness of the Magnetic Scope Guide Assist (ScopeGuide) with respect to cecal intubation time, and other procedural quality outcomes.

Patients and methods We conducted a prospective study of outpatients undergoing elective colonoscopy at the endoscopic units of the University of Alabama at Birmingham (UAB) from March 2016 to July 2016. Patients were randomly assigned in a 1:1 block design to groups that either had standard colonoscopy or Scope-guided colonoscopy. The primary outcome measure was cecal intubation time (CIT). Secondary outcome measures included use of manual pressure, position changes for cecal intubation and sedation requirements.

Results Three hundred patients were randomized to either group; standard (n = 150) vs. Scope-guided (n = 150). The mean CIT was not statistically different for the standard and the Scope-guided groups (4.6 vs. 4.3 minutes; P = 0.46). There were also no statistical differences in frequency of manual pressure applied (16.7 % for Scope-guided vs. 19.1 % for standard; P = 0.65) or position changes (11.4 % for scope guided vs. 8.8 % standard; P = 0.56). Sedation requirements showed lesser use of midazolam (3.9 mg vs. 4.7 mg, P = 0.003) in the Scope-guide group, while there was no significant difference in use of fentanyl (fentanyl – 62.1 mg vs. 68.9 mg, P = 0.09 similar between groups, for Scope-guided vs. standard groups, respectively). Adverse events were similar in both groups.

Conclusions In patients undergoing routine elective colonoscopy, use of ScopeGuide by experienced colonoscopists did not improve CIT or affect the frequency of ancillary maneuvers. The benefit of this device during training of endoscopists could be considered for further studies.
Die Bedeutung des lymphatischen und des glymphatischen Systems für das Glaukom
Authors: Killer Hanspeter
Published: February 2019

Das Normaldruckglaukom ist eine Variante des Offenwinkelglaukoms, das durch einen normalen Augendruck charakterisiert ist. Obwohl verschiedene pathophysiologische Erklärungen existieren (vaskuläre Dysregulation, Rolle der Lamina cribrosa) kann keine Theorie die Pathophysiologie schlüssig erklären. Der Sehnerv ist ein weißer Hirnfaszikel. Er ist auf seiner ganzen Länge von Liquor cerebrospinalis umspült. Auf der Basis von neuroradiologischen Untersuchungen vermutet man, dass ein Normaldruckglaukom aufgrund eines neurodegenerativen Prozesses entstehen kann. Eine ungenügende Liquordynamik kann dabei eine Rolle spielen, indem toxische Substanzen wie Aβ-Lipoprotein insuffizient aus dem Liquor entfernt werden. Dabei kommt dem lymphatischen und glymphatischen System eine wesentliche Rolle zu.
Prähospitale Anlage von Tourniquets zur Kontrolle massiver Extremitätenblutungen – ein Update
Authors: Lechner Raimund , Kulla Martin , Josse Florent , Hossfeld Björn
Published: February 2019

2016 wurde erstmals eine Handlungsempfehlung der DGAI zur prähospitalen Anwendung von Tourniquets veröffentlicht. Diese wurden 2018 anhand einer systematischen Literaturrecherche reevaluiert und grundsätzlich bestätigt. Die vorliegende Übersicht gibt einen aktuellen Überblick über die Anwendung von Tourniquets zur prähospitalen Blutungskontrolle mit einigen Ergänzungsvorschlägen zur DGAI-Handlungsempfehlung. Zusammenfassend sollte ein Tourniquet immer dann angelegt werden, wenn eine Extremitätenblutung durch Kompression einer Wunde nicht kontrolliert werden kann oder die Kompression situationsbedingt nicht durchführbar ist.
Grundlegende Basismaßnahmen und -techniken in der Notfallmedizin
Authors: Stuhr Markus
Published: February 2019

In Zeiten der zunehmenden Technologisierung der gesamten Medizin steigt auch der Anteil entsprechender Möglichkeiten in der präklinischen Notfallmedizin. Die essenziellen patientennahen Basismaßnahmen dürfen dabei aber nicht vernachlässigt werden. Dieser Beitrag soll einige Basismaßnahmen in Erinnerung bringen und deren Durchführung erläutern. Im Fokus stehen dabei Maßnahmen, die keine oder nur wenige, technisch einfache Hilfsmittel erfordern.
The patterns of phalangeal fractures in children and
adolescents: a review of 512 cases
Authors: Kralj Rok , Barcot Zoran , Vlahovic Tomislav , Kurtanjek Mario , Petracic Ivan
Published: February 2019

Introduction Fractures of the phalanges in children can often be
underappreciated by the physician of first contact. Therefore it is necessary to
point out which of these fractures, because of the risk of possible future
complications, need special mention.

Materials and Methods A retrospective review of 512 fractures of the
phalanges in children and adolescents during an one year period. Fractures were
subdivided into the following categories – physeal fractures, intraarticular
(phalangeal neck and condylar) fractures, shaft fractures, tuft fractures,
“mallet finger” fractures, volar plate avulsion injuries and collateral ligament
avulsion injuries. Main outcome measures was the necessity for operation while
the average age at which the injury has occured, the cause of the injury, the
frequency of injury of each finger, the necessity for reduction, and the
duration of splinting were the secondary outcome measures.

Results Collateral ligament avulsion injuries and intraarticular
(phalangeal neck and condylar) fractures were injuries which most often
necessitated operative treatment. Physeal injuries were the most common injuires
with avulsions of the volar plate being the second most common. Accidents during
sport was by far the most common cause of injuires in all categories apart from
tuft injuries.

Conclusion The findings regarding the incidence and the cause of these
injuries in this study support the already published dana in the literature. The
physician of first contact has to be capable to recognise the problematic
fractures – intraarticular (phalangeal neck and condylar), significantly
displaced Salter-Harris type III and IV fractures and collateral ligament
avulsion injuries and Seymour fractures.
Local recurrence of diminutive colorectal polyps after cold forceps polypectomy with jumbo forceps followed by magnified narrow-band imaging: a multicenter prospective study
Authors: Kuwai Toshio , Yamada Takuya , Toyokawa Tatsuya , Iwase Hiroaki , Kudo Tomohiro , Esaka Naoki , Ohta Hajime , Yamashita Haruhiro , Hosoda Yasuo , Watanabe Noriko , Harada Naohiko
Published: February 2019

Background Cold polypectomy has been increasingly used to remove diminutive colorectal polyps. We evaluated the local recurrence rate of diminutive polyps at the 1-year follow-up after cold forceps polypectomy (CFP).

Methods In a prospective, multicenter, observational cohort study, patients with diminutive colorectal polyps ( ≤ 5 mm) were treated by CFP using jumbo forceps followed by magnified narrow-band imaging (NBI). Patients were assessed for local recurrence at 1-year follow-up. Risk factors associated with local recurrence were analyzed using logistic regression analysis.

Results Overall, 955 lesions were resected in 471 patients who completed the 1-year follow-up. The endoscopic complete resection rate was 99.4 %. Immediate and delayed bleeding occurred in 0.8 % and 0.2 % of cases, respectively, with no perforations observed. Local recurrence occurred in 2.1 % of cases at the 1-year follow-up. Univariable analyses indicated that polyps > 3 mm (P < 0.01) and immediate bleeding (P = 0.04) were significantly associated with local recurrence. A trend was observed for patients ≥ 65 years (P = 0.06) and fractional resection (P = 0.09). Multivariable analyses confirmed that lesions > 3 mm were significantly associated with local recurrence (odds ratio 3.4, P = 0.02).

Conclusions CFP with jumbo forceps followed by NBI-magnified observation had a low local recurrence rate and is an acceptable therapeutic option for diminutive colorectal polyps. Although we recommend limiting the use of CFP with jumbo forceps to polyps ≤ 3 mm in size, future comparative studies are needed to make recommendations on cold polypectomy using either forceps or snares as the preferred approach for diminutive polyp resection.
Crossed Testicular Ectopia-A Rare Anamoly
Authors: Priya Noopur , Luthra Luv , Agrawal Sweta
Published: February 2019

Crossed Testicular Ectopia (CTE)/Transverse Testicular Ectopia (TTE) is a rare but well-known congenital anomaly, in which both gonads migrate toward the same hemiscrotum. It is usually associated with other abnormalities such as persistent Mullerian duct syndrome, True Hermaphroditism, Inguinal Hernia, Hypospadias, Pseudohermaphroditism, and scrotal anomalies. We report a case of 6 years old male child with right undescended testis and empty left scrotum. Diagnosis was confirmed preoperatively by ultrasound followed by open inguinal exploration for orchidopexy.
Malignant Gastrointestinal Stromal Tumour with Metastasis
Authors: Lakhar Bhushita , Guru Nilesh
Published: February 2019

Gastrointestinal stromal tumors (GISTs) are the most usual mesenchymal neoplasms of the gastrointestinal tract. Ever since the classification of GIST as an entity distinct from leiomyoma's, leiomyosarcomas, etc., there has been an increased concern in defining their imaging characteristics. It is estimated that approximately 5000-10,000 people are affected per year by this tumor all over the world. Most GISTs are benign (70-80%). However, these tumors have a spectrum ranging from benign to malignant lesions, depending on its anatomic site, tumor size, and mitotic frequency. We report a case of multiple malignant GIST with metastasis into Liver.
Ab initio
studies of the ground and first excited states of the Sr–H2 and Yb–H2 complexes
Authors: Cybulski Hubert
Published: February 2019

Accurate intermolecular potential-energy surfaces (IPESs) for the ground and first excited states of the Sr-H2 and Yb-H2 complexes were calculated. After an extensive methodological study, the coupled cluster with single, double, and non-iterative triple excitation method with the Douglas-Kroll-Hess Hamiltonian and correlation-consistent basis sets of triple-ζ quality extended with 2 sets of diffuse functions and a set of midbond functions were chosen. The obtained ground-state IPESs are similar in both complexes, being relatively isotropic with two minima and two transition states (equivalent by symmetry). The global minima correspond to the collinear geometries with R = 5.45 and 5.10 Å and energies of −27.7 and −31.7 cm−1 for the Sr-H2 and Yb-H2 systems, respectively. The calculated surfaces for the Sr(3P)-H2 and Yb(3P)-H2 states are deeper and more anisotropic, and they exhibit similar patterns within both complexes. The deepest surfaces, where the singly occupied p-orbital of the metal atom is perpendicular to the intermolecular axis, are characterised by the global minima of ca. −2053 and −2260 cm−1 in the T-shape geometries at R = 2.41 and 2.29 Å for Sr-H2 and Yb-H2, respectively. Additional calculations for the complexes of Sr and Yb with the He atom revealed a similar, strong dependence of the interaction energy on the orientation of the p-orbital in the Sr(3P)-He and Yb(3P)-He states.
Study on eccentricity effects of the rod-pinch diode radiography source
Authors: Geng Lidong , He Yang , Yuan Jianqiang , Wang Minhua , Cao Longbo , Feng Shuping , Xie Weiping
Published: February 2019

The rod pinch diode (RPD) is a cylindrical pinched beam diode that generates intense pulsed bremsstrahlung X-ray radiation with a small diameter. In practice, the anode and cathode structures of the RPD may be eccentric due to the mechanical deformation and mounting errors. In theory, this eccentricity changes the physical characteristics of the RPD, which in turn affects the X-ray production. To study the performance variation induced by eccentric electrodes, the electrode concentricity evaluation system is used to quantify the concentricity of the anode and cathode. Then a series of experiments are carried out with different concentricity deviations, and the electrical performance, the radiation dose, and the X-ray pulse signal among different shots are analyzed. These results have shown that, within a certain eccentricity range, the overall performances of the RPD, including the diode impedance and the X-ray production, change very little. Going beyond this range, the average impedance decay rate increases significantly, resulting in accelerated impedance collapse and shortened voltage pulse width. Consequently, X-ray dose distribution and the X-ray pulse width are both reduced. These results are helpful in understanding the RPD characteristics from a different perspective as well as providing a method to determine the designing and mounting criteria of the electrodes of rod-pinch diode.
Fluorescent scanning thermal microscope based on a Blu-ray optical head to measure thermal diffusivity of radioactive samples
Authors: Hayden Samuel , Munro Troy
Published: February 2019

Over the life of nuclear fuel, inhomogeneous structures develop, negatively impacting thermal properties. New fuels are under development but require more accurate knowledge of how the properties change to model performance and determine safe operational conditions. Measurement systems capable of microscopic thermal transport measurements and low cost are necessary to measure these properties and integrate into hot cells where electronics are likely to fail during fuel investigation. This project develops a cheaper, smaller, and easily replaceable Fluorescent Scanning Thermal Microscope (FSTM) using the blue laser and focusing circuitry from an Xbox HD-DVD player that incorporates novel fluorescent thermometry methods to determine thermal diffusivity. The FSTM requires minimal sample preparation, does not require access to both sides of the sample, and components can be easily swapped out if damaged, as is likely in irradiated hot cells. Using the optical head from the Xbox for sensing temperature changes, an infrared laser diode provides periodic heating to the sample, and the blue laser induces fluorescence in Rhodamine B deposited on the sample’s surface. Thermal properties are fit to modulated temperature models based on the phase delay response at different modulated heating frequencies. With the FSTM method, the thermal diffusivity of a Nordic gold (euro) coin was found to be 21 ± 5 mm2/s. This value is compared to laser flash and thermal conductivity microscope methods, which found the thermal diffusivity to be 30.4 ± 0.1 mm2/s and 19 ± 3 mm2/s. The system shows promise as a feasible property characterization technique with future refinement and testing in progress.
Optimized alignment of X-ray mirrors with an automated speckle-based metrology tool
Authors: Zhou T. , Wang H. , Fox O. J. L. , Sawhney K. J. S.
Published: February 2019

X-ray mirrors are widely used in beamlines and laboratories as focusing or collimating optics. As well as the highly accurate processes used to fabricate them, optimized alignment of X-ray mirrors also plays an important role in achieving an ideal X-ray beam. Currently, knife-edge scans are the most often used method for aligning X-ray mirrors, which can characterize the focal size and tune the alignment iteratively. However, knife-edge scanning provides only one-dimensional information and this method suffers from being time-consuming and requiring a high-resolution piezo translation stage. Here we describe a straightforward and non-iterative method for mirror alignment by measuring the relationship between the tilt aberration and the misaligned pitch angle, which is retrieved by an at-wavelength metrology technique using a randomly shaped wavefront modulator. Software and a graphical user interface have been developed to automate the alignment process. Combining the user-friendly interface and the flexibility of the at-wavelength metrology technique, we believe the proposed method and software can benefit researchers working at synchrotron facilities and on laboratory sources.
Deflectometry encoding the measured angle in a time-dependent intensity signal
Authors: Pedreira Pablo , Nicolas Josep , Šics Igors , Heinis Dominique , Fontserè Abel , Crisol Alejandro , Campos Juan
Published: February 2019

We propose a new concept of a deflectometer, aimed to provide high accuracy measurements with high sampling rate and low noise, as required by state-of-the-art slope-measuring profilometers, like Long Trace Profilometers or Nanometer Optics Measuring instruments. For this purpose, we introduce certain modifications to the usual working principle of autocollimators so that the measured angle is not given by the displacement of the pattern captured by a CCD, but by the harmonic contents of the time-modulated intensity signal acquired by a photodiode. By doing this, the signal can be sampled not by just a few thousand pixels but by millions of samples/s.