bluuebunny/crossref_metadata_2025 huggingface dataset:
A new frontier in Texas: managing and regulating brackish groundwater
Authors: Buono Regina M. , Zodrow Katherine R. , Alvarez Pedro J. J. , Li Qilin
Published: December 2015

The challenge of providing access to clean water is visible in Texas, where chronic drought coincides with increasing water demand. The 2012 Texas State Water Plan reports a 2,700 million cubic metres (MCM) gap between freshwater supply and demand in 2010, a number predicted to grow to 3,100 MCM by 2060. Due to the difficulty of reducing water demand, policy makers and water providers are evaluating new sources, including brackish groundwater for desalination or direct use. It is estimated that Texas aquifers contain more than 3,300,000 MCM of brackish groundwater, which, if converted to fresh water, could meet current consumption needs for 150 years, albeit at a greater cost. Using Texas as a case study, this article addresses policies to better manage the supply of brackish groundwater. We review the geological, technical, and legal contexts of groundwater in Texas and situate brackish groundwater within those constructs. We consider efforts by other states to regulate brackish groundwater and identify management goals, including facilitating access to and incentivizing use of brackish groundwater and protecting freshwater aquifers from potential saline intrusion related to brackish groundwater production. Various brackish groundwater policies are examined, and policy recommendations regarding use of the resource are offered.
Irrigation water demand and implications for groundwater pricing in Pakistan
Authors: Watto Muhammad Arif , Mugera Amin William
Published: December 2015

This study employs the positive mathematical programming (PMP) approach to estimate groundwater derived demand for irrigation using a cross-sectional dataset of 200 predominantly groundwater irrigated farms from the Punjab province of Pakistan. First, we find that the PMP optimal solution uses less water than what is available (being extracted) in order to make farmers allocate all the available land to different crops. Second, when water supplies are constrained farmers allocate land to different crops based on their total returns, not on the irrigation water requirements. The study results suggest that the limiting/constraining groundwater extractions would induce farmers to reconsider their irrigation water demand. The study findings suggest an introduction of Rs. 0.04/m3 of groundwater would not decrease farm income rather it would make farmers aware of the economic value of water. We suggest that although water pricing can induce an efficient use of groundwater extractions, additional policies are also required that improve irrigation water use efficiency.
Crisis in the Mediterranean neighbourhood: A test for the European union migration policy
Authors: Stojanovic Nikola
Published: December 2015

The paper analyses the implementation of the EU immigration and asylum policy
and the control of EU member states' external borders in the aftermath of the
Arab Spring. The author argues that the European Union pursues an exclusive
version of those policies aimed at reducing the immigration pressure as well
as preventing illegal border crossings into the member states. Two key
mechanisms have been identified in the EU policy implementation: 1) a
restrictive border control regime, and 2) agreements to transfer border
management and supervision tasks to the third countries (transitional
countries). The author emphasizes that the development of an exclusive
migration strategy was not followed by the needed changes of the inclusive
aspects of the EU immigration and asylum policy and the control of external
borders; in fact, the EU member state's asylum systems were not preventively
strengthened as to enhance national capacities to receive and integrate new
migrants. The dramatic increase of the number of illegal crossings of the
European Union external borders in 2014 caused the collapse of the EU
immigration strategy, and failures in national asylum systems of the member
states. The author concludes that partially integrated EU immigration and
asylum policy at national level led to the dysfunctional external border
management and the EU's loss of control over massive immigration influxes.
Review of the Conference on Security and Cooperation in Europe: 40 years after Helsinki
Authors: Dimitrijevic Dusko
Published: December 2015

The paper deals with the genesis of the Conference on Security and
Cooperation in Europe (CSCE) as the important pan-European forum for
addressing security issues during the Cold War era, and, secondly, analyses
the dynamics of institutional changes that led to establishment of the
Organisation for Security and Cooperation in Europe (OSCE). As an active
factor in the process of d?tente and the easing of tensions between the then
USSR and the United States, the CSCE was the place in which were flowing all
initiatives related to overcoming the security problems in bipolar Europe.
The paper provides a brief of negotiation process that produced the Helsinki
Final Act of 1975, an international political document that laid down the
basic principles of interstate relations and political commitments in a
number of areas, from military-political security, to economic and
environmental co-operation and human rights. The author concludes that the
role of the OSCE is likely to stagnate in the 21st century, for it will not
be sufficiently capable to influence Euro-Atlantic and Euroasian affairs, and
to maintain its function as an important consultative and negotiating
mechanism, as well as a platform for regional security and cooperation.
On Matrix Sampling and Imputation of Context Questionnaires With Implications for the Generation of Plausible Values in Large-Scale Assessments
Authors: Kaplan David , Su Dan
Published: December 2015

This article presents findings on the consequences of matrix sampling of context questionnaires for the generation of plausible values in large-scale assessments. Three studies are conducted. Study 1 uses data from PISA 2012 to examine several different forms of missing data imputation within the chained equations framework: predictive mean matching, Bayesian linear regression, and proportional odds logistic regression. We find that predictive mean matching accurately reproduces the marginal distributions of the missing context questionnaire data due to matrix sampling. Study 2 uses data from PISA 2006 to examine the consequences of imputing context questionnaire data in terms of the generation of plausible values. We find that imputing context questionnaire data with predictive mean matching and using the imputed data to produce the plausible values yields very close approximation of the original marginal distributions but leads to underestimation of the correlation structure of the context questionnaire items. Study 3 examines imputation and plausible values generation within a partially balanced incomplete block design. We find that imputation within this design accurately reproduces the original marginal distributions and retains the correlation structure of the data. Implications for context questionnaire development are discussed.
Analysis of Tetracyclines in Medicated Feed for Food Animal Production by HPLC-MS/MS
Authors: Gavilán Rosa , Nebot Carolina , Miranda Jose , Martín-Gómez Yolanda , Vázquez-Belda Beatriz , Franco Carlos , Cepeda Alberto
Published: December 2015

The use of medicated feed is a common practice in animal food production to improve animal health. Tetracyclines and β-Lactams are the groups that are most frequently added to this type of feed. The measurement of the concentration of the analytes in these types of samples is sometimes due to the matrix characteristic, and manufacturers are demanding fast, precise and reproducible methods. A rapid confirmatory method based on a simple extraction protocol using acidified methanol and followed by high performance liquid chromatography coupled to a tandem mass spectrometer for the quantification of four tetracyclines in feed is presented. Validation was performed following the guidelines of Decision 2002/657/EC. Results indicated that the four tetracyclines can be identified and quantified in a concentration range between 50 and 500 mg/kg with recoveries between 84% and 109% and RSD for precision under reproducible conditions between 12% and 16%. Satisfactory results were also obtained with interlaboratory studies and by comparing the method with an HPLC-Fluorescent method.
Auralization of Accelerating Passenger Cars Using Spectral Modeling Synthesis
Authors: Pieren Reto , Bütler Thomas , Heutschi Kurt
Published: December 2015

While the technique of auralization has been in use for quite some time in architectural acoustics, the application to environmental noise has been discovered only recently. With road traffic noise being the dominant noise source in most countries, particular interest lies in the synthesis of realistic pass-by sounds. This article describes an auralizator for pass-bys of accelerating passenger cars. The key element is a synthesizer that simulates the acoustical emission of different vehicles, driving on different surfaces, under different operating conditions. Audio signals for the emitted tire noise, as well as the propulsion noise are generated using spectral modeling synthesis, which gives complete control of the signal characteristics. The sound of propulsion is synthesized as a function of instantaneous engine speed, engine load and emission angle, whereas the sound of tires is created in dependence of vehicle speed and emission angle. The sound propagation is simulated by applying a series of time-variant digital filters. To obtain the corresponding steering parameters of the synthesizer, controlled experiments were carried out. The tire noise parameters were determined from coast-by measurements of passenger cars with idling engines. To obtain the propulsion noise parameters, measurements at different engine speeds, engine loads and emission angles were performed using a chassis dynamometer. The article shows how, from the measured data, the synthesizer parameters are calculated using audio signal processing.
Acoustic Emission Activity for Characterizing Fracture of Marble under Bending
Authors: Tsangouri Eleni , Aggelis Dimitrios , Matikas Theodore , Mpalaskas Anastasios
Published: December 2015

The present paper occupies with the acoustic emission (AE) monitoring of fracture of marble. The specimens belong to two different material types and were tested in three-point bending after being ultrasonically interrogated. Consequently, they were repaired by means of suitable epoxy agent and mechanically re-loaded. Apart from the well-known correlation of pulse velocity to strength, which holds for the materials of this study as well, AE provides some unique insight in the fracture of the media. Parameters like the frequency content of the waveforms, and their duration among others show a transition in relation to the load. According to their strength class, the specimens exhibit distinct AE characteristics even at low load, enabling to judge their final strength class after having sustained just a small percentage of their ultimate capacity. More importantly, the AE activity during reloading indicates the quality of repair; specimens with good restoration of strength, exhibited similar AE activity to the intact specimens, while specimens with lower repaired capacity exhibited random behavior. This work discusses the passive monitoring of marble fracture and shows that AE parameters that have been used to successfully characterize cementitious materials, provide good results in monolithic materials like marble as well. It is suggested that AE monitoring during a proof loading can provide good information on the potential strength class, which is especially useful for repaired specimens, where the pulse velocity cannot be easily used.
Rebalancing Redox to Improve Biobutanol Production by Clostridium tyrobutyricum
Authors: Ma Chao , Ou Jianfa , Xu Ningning , Fierst Janna , Yang Shang-Tian , Liu Xiaoguang
Published: December 2015

Biobutanol is a sustainable green biofuel that can substitute for gasoline. Carbon flux has been redistributed in Clostridium tyrobutyricum via metabolic cell engineering to produce biobutanol. However, the lack of reducing power hampered the further improvement of butanol production. The objective of this study was to improve butanol production by rebalancing redox. Firstly, a metabolically-engineered mutant CTC-fdh-adhE2 was constructed by introducing heterologous formate dehydrogenase (fdh) and bifunctional aldehyde/alcohol dehydrogenase (adhE2) simultaneously into wild-type C. tyrobutyricum. The mutant evaluation indicated that the fdh-catalyzed NADH-producing pathway improved butanol titer by 2.15-fold in the serum bottle and 2.72-fold in the bioreactor. Secondly, the medium supplements that could shift metabolic flux to improve the production of butyrate or butanol were identified, including vanadate, acetamide, sodium formate, vitamin B12 and methyl viologen hydrate. Finally, the free-cell fermentation produced 12.34 g/L of butanol from glucose using the mutant CTC-fdh-adhE2, which was 3.88-fold higher than that produced by the control mutant CTC-adhE2. This study demonstrated that the redox engineering in C. tyrobutyricum could greatly increase butanol production.
Diurnal Thermal Behavior of Pavements, Vegetation, and Water Pond in a Hot-Humid City
Authors: Yang Xiaoshan , Zhao Lihua
Published: December 2015

This study investigated the diurnal thermal behavior of several urban surfaces and landscape components, including pavements, vegetation, and a water pond. The field experiment was conducted in a university campus of Guangzhou, South China, which is characterized by a hot and humid summer. The temperature of ground surface and grass leaves and the air temperature and humidity from 0.1 to 1.5 m heights were measured for a period of 24 h under hot summer conditions. The results showed that the concrete and granite slab pavements elevated the temperature of the air above them throughout the day. In contrast, the trees and the pond lowered the air temperature near ground during the daytime but produced a slight warming effect during the nighttime. The influence of vegetation on air temperature and humidity is affected by the configurations of greenery. Compared to the open lawn, the grass shaded by trees was more effective in cooling and the mixture of shrub and grass created a stronger cooling effect during the nighttime. The knowledge of thermal behavior of various urban surfaces and landscape components is an important tool for planners and designers. If utilized properly, it can lead to climatic rehabilitation in urban areas and an improvement of the outdoor thermal environment.
Phosphotungstate-Based Ionic Silica Nanoparticles Network for Alkenes Epoxidation
Authors: Li Xiaoting , Jiang Pingping , Wang Zhuangqing , Huang Yuandan
Published: December 2015

An inorganic-organic porous silica network catalyst was prepared by linking silica nanoparticles using ionic liquid and followed by anion-exchange with phosphotungstate. Characterization methods of FT-IR, TG, SEM, TEM, BET, etc., were carried out to have a comprehensive insight into the catalyst. The catalyst was used for catalyzing cyclooctene epoxidation with high surface area, high catalytic activity, and convenient recovery. The conversion and selectivity of epoxy-cyclooctene could both reach over 99% at 70 °C for 8 h using hydrogen peroxide (H2O2) as an oxidant, and acetonitrile as a solvent when the catalyst was 10 wt. % of cyclooctene.
Structural Elucidation of α-Cyclodextrin-Succinic Acid Pseudo Dodecahydrate: Expanding the Packing Types of α-Cyclodextrin Inclusion Complexes
Authors: Saouane Sofiane , Fabbiani Francesca
Published: December 2015

This paper reports a new packing type of α-cyclodextrin inclusion complexes, obtained here with succinic acid under low-temperature crystallization conditions. The structure of the 1:1 complex is characterized by heavy disorder of the guest, the solvent, and part of the host. The crystal packing belongs to the known channel-type structure; the basic structural unit is composed of cyclodextrin trimers, as opposed to the known isolated molecular or dimeric constructs, packed along the c-axis. Each trimer is made of crystallographically independent molecules assembled in a stacked vase-like cluster. A multi-temperature single-crystal X-ray diffraction analysis reveals the presence of dynamic disorder.
Screening of Hanseniaspora Strains for the Production of Enzymes with Potential Interest for Winemaking
Authors: López Sandra , Mateo José , Maicas Sergi
Published: December 2015

Some non-Saccharomyces yeasts, including Hanseniaspora, participate in the first stages of wine fermentation. Besides their importance in the wine production process some of these yeasts have been described to be potential producers of hydrolytic enzymes to industrial level. In this work, we pretend to evaluate the technological abilities of the Hanseniaspora strains deposited in the Spanish Type Culture Collection (CECT). First of all, we considered verification of the correct identification of the strains using several miniaturized biochemical systems and molecular techniques (PCR, RFLP and sequencing of the ribosomal D1/D2 region). The results allowed us to verify the correct adscription of the 26 strains included in this study, which exhibited concordant profiles of restriction with one of the three species described in previous studies (H. occidentalis, H. osmophila and H. valbyensis). Some other strains assigned to the species (H. uvarum, H. vineae and H. guilliermondii) showed at least two different profiles. The other objective of this study was to perform an initial screening to characterize both at quantitative and qualitative levels, the ability of these yeasts to produce valuable enzymes for wine fermentation (increase of aroma) and other applications. The more important enzymatic activities detected were β-glucosidase, β-xylosidase, and protease. The HU7, HU8, HV1, HV3, HO2 and HOC1 strains showed high levels of β-glucosidase and β-xylosidase activity, whereas some strains (HG1, HG3, HVA1, HOC 3 and HOC4 were useful for protease production.
Water Sorption Isotherm of Pea Starch Edible Films and Prediction Models
Authors: Saberi Bahareh , Vuong Quan , Chockchaisawasdee Suwimol , Golding John , Scarlett Christopher , Stathopoulos Costas
Published: December 2015

The moisture sorption isotherm of pea starch films prepared with various glycerol contents as plasticizer was investigated at different storage relative humidities (11%–96% RH) and at 5 ± 1, 15 ± 1, 25 ± 1 and 40 ± 1 °C by using gravimetric method. The results showed that the equilibrium moisture content of all films increased substantially above aw = 0.6. Films plasticized with glycerol, under all temperatures and RH conditions (11%–96%), adsorbed more moisture resulting in higher equilibrium moisture contents. Reduction of the temperature enhanced the equilibrium moisture content and monolayer water of the films. The obtained experimental data were fitted to different models including two-parameter equations (Oswin, Henderson, Brunauer–Emmitt–Teller (BET), Flory–Huggins, and Iglesias–Chirife), three-parameter equations Guggenhiem–Anderson–deBoer (GAB), Ferro–Fontan, and Lewicki) and a four-parameter equation (Peleg). The three-parameter Lewicki model was found to be the best-fitted model for representing the experimental data within the studied temperatures and whole range of relative humidities (11%–98%). Addition of glycerol increased the net isosteric heat of moisture sorption of pea starch film. The results provide important information with estimating of stability and functional characteristics of the films in various environments.
Hidden Imprints of Minor Merging in Early-Type Galaxies: Inner Polar Rings and Inclined Large-Scale Gaseous Disks In S0s
Authors: Sil’chenko Olga
Published: December 2015

I discuss my latest observational data and ideas about decoupled gaseous subsystems in nearby lenticular galaxies. As an extreme case of inclined gaseous disks, I demonstrate a sample of inner polar disks, derive their incidence, about 10% among the volume-limited nearby S0 galaxies, and discuss their origin. However, large-scale decoupled gaseous disks at intermediate inclinations are also a rather common phenomenon among the field S0 galaxies. I suggest that the geometry of outer gas accretion and the final morphology of the galaxy may be tightly related: inclined gas infall may prevent star formation in the accreted disk and force the disk galaxy to be a lenticular.
Transmission of Smoking across Three Generations in Finland
Authors: El-Amin Salma , Kinnunen Jaana , Ollila Hanna , Helminen Mika , Alves Joana , Lindfors Pirjo , Rimpelä Arja
Published: December 2015

The influence of parents’ smoking on children’s smoking is well known, but few studies have examined the association between grandparents’ and grandchildren’s smoking. We studied the association between paternal and maternal grandparents’ smoking and their grandchildren’s tobacco use and assessed whether parents’ smoking is a mediator in this process. Data were obtained from a national survey of 12–18-year-old Finns in 2013 (N = 3535, response rate 38%). Logistic regression and mediation analyses were used. Both boys and girls had higher odds for smoking experimentation, daily smoking and other tobacco or tobacco-like product use if their mother, father or any of the four grandparents were current or former smokers. When parents’ and grandparents’ smoking status were included in the same model, grandparents’ smoking generally lost statistical significance. In the mediation analysis, 73% of the total effect of grandparents’ smoking on grandchildren’s daily smoking was mediated through parents’ smoking, 64% on smoking experimentation and 63% on other tobacco or tobacco-like product use. The indirect effect of a mother’s smoking was higher than that of a father’s. To conclude, paternal and maternal grandparents’ smoking increases grandchildren’s tobacco use. The influence is mainly, but not completely, mediated through parents’ smoking.
Identifying Watershed Regions Sensitive to Soil Erosion and Contributing to Lake Eutrophication—A Case Study in the Taihu Lake Basin (China)
Authors: Lin Chen , Ma Ronghua , He Bin
Published: December 2015

Taihu Lake in China is suffering from severe eutrophication partly due to non-point pollution from the watershed. There is an increasing need to identify the regions within the watershed that most contribute to lake water degradation. The selection of appropriate temporal scales and lake indicators is important to identify sensitive watershed regions. This study selected three eutrophic lake areas, including Meiliang Bay (ML), Zhushan Bay (ZS), and the Western Coastal region (WC), as well as multiple buffer zones next to the lake boundary as the study sites. Soil erosion intensity was designated as a watershed indicator, and the lake algae area was designated as a lake quality indicator. The sensitive watershed region was identified based on the relationship between these two indicators among different lake divisions for a temporal sequence from 2000 to 2012. The results show that the relationship between soil erosion modulus and lake quality varied among different lake areas. Soil erosion from the two bay areas was more closely correlated with water quality than soil erosion from the WC region. This was most apparent at distances of 5 km to 10 km from the lake, where the r2 was as high as 0.764. Results indicate that soil erosion could be used as an indicator for identifying key watershed protection areas. Different lake areas need to be considered separately due to differences in geographical features, land use, and the corresponding effects on lake water quality.
Discontinuous and Continuous Indoor Air Quality Monitoring in Homes with Fireplaces or Wood Stoves as Heating System
Authors: De Gennaro Gianluigi , Dambruoso Paolo , Di Gilio Alessia , Di Palma Valerio , Marzocca Annalisa , Tutino Maria
Published: December 2015

Around 50% of the world’s population, particularly in developing countries, uses biomass as one of the most common fuels. Biomass combustion releases a considerable amount of various incomplete combustion products, including particulate matter (PM) and polycyclic aromatic hydrocarbons (PAHs). The paper presents the results of Indoor Air Quality (IAQ) measurements in six houses equipped with wood burning stoves or fireplaces as heating systems. The houses were monitored for 48-h periods in order to collect PM10 samples and measure PAH concentrations. The average, the maximum and the lowest values of the 12-h PM10 concentration were 68.6 μg/m3, 350.7 μg/m3 and 16.8 μg/m3 respectively. The average benzo[a]pyrene 12-h concentration was 9.4 ng/m3, while the maximum and the minimum values were 24.0 ng/m3 and 1.5 ng/m3, respectively. Continuous monitoring of PM10, PAHs, Ultra Fine Particle (UFP) and Total Volatile Organic Compounds (TVOC) was performed in order to study the progress of pollution phenomena due to biomass burning, their trends and contributions to IAQ. The results show a great heterogeneity of impacts on IAQ in terms of magnitude and behavior of the considered pollutants’ concentrations. This variability is determined by not only different combustion technologies or biomass quality, but overall by different ignition mode, feeding and flame management, which can also be different for the same house. Moreover, room dimensions and ventilation were significant factors for pollution dispersion. The increase of PM10, UFP and PAH concentrations, during lighting, was always detected and relevant. Continuous monitoring allowed singling out contributions of other domestic sources of considered pollutants such as cooking and cigarettes. Cooking contribution produced an impact on IAQ in same cases higher than that of the biomass heating system.
A Comparative Study of Scientific Publications in Health Care Sciences and Services from Mainland China, Taiwan, Japan, and India (2007–2014)
Authors: Lv Yipeng , Tang Bihan , Liu Xu , Xue Chen , Liu Yuan , Kang Peng , Zhang Lulu
Published: December 2015

In this study, we aimed to compare the quantity and quality of publications in health care sciences and services journals from the Chinese mainland, Taiwan, Japan, and India. Journals in this category of the Science Citation Index Expanded were included in the study. Scientific papers were retrieved from the Web of Science online database. Quality was measured according to impact factor, citation of articles, number of articles published in top 10 journals, and the 10 most popular journals by country (area). In the field of health care sciences and services, the annual incremental rates of scientific articles published from 2007 to 2014 were higher than rates of published scientific articles in all fields. Researchers from the Chinese mainland published the most original articles and reviews and had the highest accumulated impact factors, highest total article citations, and highest average citation. Publications from India had the highest average impact factor. In the field of health care sciences and services, China has made remarkable progress during the past eight years in the annual number and percentage of scientific publications. Yet, there is room for improvement in the quantity and quality of such articles.
Prediction of Protein Structural Class Based on Gapped-Dipeptides and a Recursive Feature Selection Approach
Authors: Liu Taigang , Qin Yufang , Wang Yongjie , Wang Chunhua
Published: December 2015

The prior knowledge of protein structural class may offer useful clues on understanding its functionality as well as its tertiary structure. Though various significant efforts have been made to find a fast and effective computational approach to address this problem, it is still a challenging topic in the field of bioinformatics. The position-specific score matrix (PSSM) profile has been shown to provide a useful source of information for improving the prediction performance of protein structural class. However, this information has not been adequately explored. To this end, in this study, we present a feature extraction technique which is based on gapped-dipeptides composition computed directly from PSSM. Then, a careful feature selection technique is performed based on support vector machine-recursive feature elimination (SVM-RFE). These optimal features are selected to construct a final predictor. The results of jackknife tests on four working datasets show that our method obtains satisfactory prediction accuracies by extracting features solely based on PSSM and could serve as a very promising tool to predict protein structural class.
Enzymatic Kinetic Resolution of 2-Piperidineethanol for the Enantioselective Targeted and Diversity Oriented Synthesis
Authors: Perdicchia Dario , Christodoulou Michael , Fumagalli Gaia , Calogero Francesco , Marucci Cristina , Passarella Daniele
Published: December 2015

2-Piperidineethanol (1) and its corresponding N-protected aldehyde (2) were used for the synthesis of several natural and synthetic compounds. The existence of a stereocenter at position 2 of the piperidine skeleton and the presence of an easily-functionalized group, such as the alcohol, set 1 as a valuable starting material for enantioselective synthesis. Herein, are presented both synthetic and enzymatic methods for the resolution of the racemic 1, as well as an overview of synthesized natural products starting from the enantiopure 1.
PPARs Link Early Life Nutritional Insults to Later Programmed Hypertension and Metabolic Syndrome
Authors: Tain You-Lin , Hsu Chien-Ning , Chan Julie
Published: December 2015

Hypertension is an important component of metabolic syndrome. Adulthood hypertension and metabolic syndrome can be programmed in response to nutritional insults in early life. Peroxisome proliferator-activated receptors (PPARs) serve as a nutrient-sensing signaling linking nutritional programming to hypertension and metabolic syndrome. All three members of PPARs, PPARα, PPARβ/δ, and PPARγ, are expressed in the kidney and involved in blood pressure control. This review provides an overview of potential clinical applications of targeting on the PPARs in the kidney to prevent programmed hypertension and metabolic syndrome, with an emphasis on the following areas: mechanistic insights to interpret programmed hypertension; the link between the PPARs, nutritional insults, and programmed hypertension and metabolic syndrome; the impact of PPAR signaling pathway in a maternal high-fructose model; and current experimental studies on early intervention by PPAR modulators to prevent programmed hypertension and metabolic syndrome. Animal studies employing a reprogramming strategy via targeting PPARs to prevent hypertension have demonstrated interesting results. It is critical that the observed effects on developmental reprogramming in animal models are replicated in human studies, to halt the globally-growing epidemic of metabolic syndrome-related diseases.
Detection of Interactions between Proteins through Rotation Forest and Local Phase Quantization Descriptors
Authors: Wong Leon , You Zhu-Hong , Ming Zhong , Li Jianqiang , Chen Xing , Huang Yu-An
Published: December 2015

Protein-Protein Interactions (PPIs) play a vital role in most cellular processes. Although many efforts have been devoted to detecting protein interactions by high-throughput experiments, these methods are obviously expensive and tedious. Targeting these inevitable disadvantages, this study develops a novel computational method to predict PPIs using information on protein sequences, which is highly efficient and accurate. The improvement mainly comes from the use of the Rotation Forest (RF) classifier and the Local Phase Quantization (LPQ) descriptor from the Physicochemical Property Response (PR) Matrix of protein amino acids. When performed on three PPI datasets including Saccharomyces cerevisiae, Homo sapiens, and Helicobacter pylori, we obtained good results of average accuracies of 93.8%, 97.96%, and 89.47%, which are much better than in previous studies. Extensive validations have also been explored to evaluate the performance of the Rotation Forest ensemble classifier with the state-of-the-art Support Vector Machine classifier. These promising results indicate that the proposed method might play a complementary role for future proteomics research.
Novel Insights into Guide RNA 5′-Nucleoside/Tide Binding by Human Argonaute 2
Authors: Kalia Munishikha , Willkomm Sarah , Claussen Jens , Restle Tobias , Bonvin Alexandre
Published: December 2015

The human Argonaute 2 (hAgo2) protein is a key player of RNA interference (RNAi). Upon complex formation with small non-coding RNAs, the protein initially interacts with the 5′-end of a given guide RNA through multiple interactions within the MID domain. This interaction has been reported to show a strong bias for U and A over C and G at the 5′-position. Performing molecular dynamics simulations of binary hAgo2/OH–guide–RNA complexes, we show that hAgo2 is a highly flexible protein capable of binding to guide strands with all four possible 5′-bases. Especially, in the case of C and G this is associated with rather large individual conformational rearrangements affecting the MID, PAZ and even the N-terminal domains to different degrees. Moreover, a 5′-G induces domain motions in the protein, which trigger a previously unreported interaction between the 5′-base and the L2 linker domain. Combining our in silico analyses with biochemical studies of recombinant hAgo2, we find that, contrary to previous observations, hAgo2 is capable of functionally accommodating guide strands regardless of the 5′-base.
Effect of Outflow Tract Banding on Embryonic Cardiac Hemodynamics
Authors: Chivukula Venkat , Goenezen Sevan , Liu Aiping , Rugonyi Sandra
Published: December 2015

We analyzed heart wall motion and blood flow dynamics in chicken embryos using in vivo optical coherence tomography (OCT) imaging and computational fluid dynamics (CFD) embryo-specific modeling. We focused on the heart outflow tract (OFT) region of day 3 embryos, and compared normal (control) conditions to conditions after performing an OFT banding intervention, which alters hemodynamics in the embryonic heart and vasculature. We found that hemodynamics and cardiac wall motion in the OFT are affected by banding in ways that might not be intuitive a priori. In addition to the expected increase in ventricular blood pressure, and increase blood flow velocity and, thus, wall shear stress (WSS) at the band site, the characteristic peristaltic-like motion of the OFT was altered, further affecting flow and WSS. Myocardial contractility, however, was affected only close to the band site due to the physical restriction on wall motion imposed by the band. WSS were heterogeneously distributed in both normal and banded OFTs. Our results show how banding affects cardiac mechanics and can lead, in the future, to a better understanding of mechanisms by which altered blood flow conditions affect cardiac development leading to congenital heart disease.
Microsporidiosis in Vertebrate Companion Exotic Animals
Authors: Vergneau-Grosset Claire , Larrat Sylvain
Published: December 2015

Veterinarians caring for companion animals may encounter microsporidia in various host species, and diagnosis and treatment of these fungal organisms can be particularly challenging. Fourteen microsporidial species have been reported to infect humans and some of them are zoonotic; however, to date, direct zoonotic transmission is difficult to document versus transit through the digestive tract. In this context, summarizing information available about microsporidiosis of companion exotic animals is relevant due to the proximity of these animals to their owners. Diagnostic modalities and therapeutic challenges are reviewed by taxa. Further studies are needed to better assess risks associated with animal microsporidia for immunosuppressed owners and to improve detection and treatment of infected companion animals.
Dependence of Liquid Supercooling on Liquid Overheating Levels of Al Small Particles
Authors: Mei Qingsong , Li Juying
Published: December 2015

The liquid thermal history effect on liquid supercooling behavior has been found in various metals and alloys; typically the degree of liquid supercooling (ΔT−) increases with the increase of liquid overheating (ΔT+) up to several to tens of degrees above the equilibrium melting point (T0). Here we report quantitative experimental measurements on the ΔT−-ΔT+ relationship of Al small particles encapsulated in Al2O3 shells by using a differential scanning calorimeter. We find a remarkable dependence of ΔT− on ΔT+ of Al small particles, extending to at least 340 °C above T0 of Al (~1.36T0), which indicates the existence of temperature-dependent crystallization centers in liquid Al up to very high liquid overheating levels. Our results demonstrate quantitatively the significant effect of liquid thermal history on the supercooling behavior of Al and its alloys, and raise new considerations about the dependence of ΔT− on ΔT+ at very high ΔT+ levels.
Evolution of the Annealing Twin Density during δ-Supersolvus Grain Growth in the Nickel-Based Superalloy Inconel™ 718
Authors: Jin Yuan , Bernacki Marc , Agnoli Andrea , Lin Brian , Rohrer Gregory , Rollett Anthony , Bozzolo Nathalie
Published: December 2015

Grain growth experiments were performed on Inconel™ 718 to investigate the possible correlation of the annealing twin density with grain size and with annealing temperature. Those experiments were conducted at different temperatures in the δ supersolvus domain and under such conditions that only capillarity forces were involved in the grain boundary migration process. In the investigated range, there is a strong inverse correlation of the twin density with the average grain size. On the other hand, the twin density at a given average grain size is not sensitive to annealing temperature. Consistent with previous results for pure nickel, the twin density evolution in Inconel™ 718 is likely to be mainly controlled by the propagation of the pre-existing twins of the growing grains; i.e., the largest ones of the initial microstructure. Almost no new twin boundaries are created during the grain growth process itself. Therefore, the twin density at a given average grain size is mainly dependent on the twin density in the largest grains of the initial microstructure and independent of the temperature at which grains grow. Based on the observations, a mean field model is proposed to predict annealing twin density as a function of grain size during grain growth.
Cross-Sectional Associations between Empirically-Derived Dietary Patterns and Indicators of Disease Risk among University Students
Authors: Blondin Stacy , Mueller Megan , Bakun Peter , Choumenkovitch Silvina , Tucker Katherine , Economos Christina
Published: December 2015

The transition from adolescence to adulthood is a unique period during which lifelong dietary habits are shaped. Dietary patterns (DPs) among young adults attending college have not been adequately described, and associations between DPs and indicators of disease risk are not well understood in this age group. Dietary data were collected from undergraduates participating in the Tufts Longitudinal Health Study (TLHS; 1998–2007) by Food Frequency Questionnaire (FFQ; n = 1323). DPs were derived using principal components analysis with varimax rotation. Scree plots; eigenvalues; factor loadings; and previous studies were used to determine and label the DPs retained. Cross-sectional relationships between DP scores and anthropometric measures (percent body fat (PBF) and (BMI) and lipid biomarkers (total; HDL and LDL cholesterol; and triglycerides) were assessed with multivariable regression models; adjusted for demographics; physical activity; smoking; intention to gain/lose weight; and total energy intake. Effect modification by sex was tested. Three DPs were identified: Prudent; Western; and Alcohol. Greater adherence to the Prudent DP was associated with favorable anthropometric outcomes. The Alcohol DP was associated with a favorable lipid profile. Associations between the Western DP and blood lipids differed by sex; with unfavorable impact observed only among males. Our findings add to the literature linking DPs in young adults with measurable adiposity and cardiometabolic outcomes; suggesting that improving nutrition among college students could reduce chronic disease risk.
Positioning a Paediatric Compounded Non-Sterile Product Electronic Repository (pCNPeRx) within the Health Information Technology Infrastructure
Authors: Parrish, II Richard
Published: December 2015

Numerous gaps in the current medication use system impede complete transmission of electronically identifiable and standardized extemporaneous formulations as well as a uniform approach to medication therapy management (MTM) for paediatric patients. The Pharmacy Health Information Technology Collaborative (Pharmacy HIT) identified six components that may have direct importance for pharmacy related to medication use in children. This paper will discuss key positions within the information technology infrastructure (HIT) where an electronic repository for the medication management of paediatric patients’ compounded non-sterile products (pCNP) and care provision could be housed optimally to facilitate and maintain transmission of e-prescriptions (eRx) from initiation to fulfillment. Further, the paper will propose key placement requirements to provide for maximal interoperability of electronic medication management systems to minimize disruptions across the continuum of care.
PLAT4M: Progressing Silicon Photonics in Europe
Authors: Scarcella Carmelo , Lee Jun , Eason Cormac , Antier Marie , Bourderionnet Jerome , Larat Christian , Lallier Eric , Brignon Arnaud , Spuesens Thijs , Verheyen Peter , Absil Philippe , Baets Roel , O‘Brien Peter
Published: December 2015

Photonic integration is an appealing technology for emerging applications in communications, medical diagnostics and sensing. Silicon Photonics presents a highly attractive solution for large-scale photonic integration, principally because it is based on well-established CMOS-fabrication technologies. However, Silicon photonics can be difficult and expensive to implement, as it requires complex device design, fabrication and packaging capabilities. Photonic Libraries And Technology for Manufacturing (PLAT4M) is a major European project that brings together the key capabilities required to develop solutions for a range of Silicon photonic-based applications. This paper will present an overview of the PLAT4M project. It will present, in detail, a key application demonstrator (Coherent Beam Combiner), highlighting the ability of the project team to develop an integrated Silicon Photonic sub-system, from design, through to device fabrication, packaging and final test. The paper also highlights the need to consider additional capabilities besides device fabrication, such as packaging, which are critical to achieving fully operational sub-systems.
High Dielectric Performance of Polyamide 66/Poly(Vinylidene Fluoride) Flexible Blends Induced by Interfacial Copolymer for Capacitors
Authors: Li Rui , Chen Zixuan , Pei Jianzhong
Published: December 2015

The copolymer VAMA was synthesized from vinyl acetic and maleic anhydride. A new all-polymeric blend with a high dielectric constant (ε) has been developed by blending polyvinylidene fluoride (PVDF) with vinyl acetic-maleic anhydride modified polyamide (PA66-g-VM). The blend shows high dielectric constants (εblend = 20) and excellent mechanical properties. The SEM investigations suggest that the enhanced dielectric behavior originates from significant interfacial interactions between polymers. The XRD demonstrates that the compatibilizer affects the crystalline behavior of each component. Furthermore, the stable dielectric constants of the all-polymeric blends can be tuned by adjusting the content of the compatibilizer. The created high-ε all-polymeric blends represent a novel type of material that is technologically simple, easy to process, and of a relatively high dielectric constant, with application for flexible electronics.
Application of Synthetic NDVI Time Series Blended from Landsat and MODIS Data for Grassland Biomass Estimation
Authors: Zhang Binghua , Zhang Li , Xie Dong , Yin Xiaoli , Liu Chunjing , Liu Guang
Published: December 2015

Accurate monitoring of grassland biomass at high spatial and temporal resolutions is important for the effective utilization of grasslands in ecological and agricultural applications. However, current remote sensing data cannot simultaneously provide accurate monitoring of vegetation changes with fine temporal and spatial resolutions. We used a data-fusion approach, namely the spatial and temporal adaptive reflectance fusion model (STARFM), to generate synthetic normalized difference vegetation index (NDVI) data from Moderate-Resolution Imaging Spectroradiometer (MODIS) and Landsat data sets. This provided observations at fine temporal (8-d) and medium spatial (30 m) resolutions. Based on field-sampled aboveground biomass (AGB), synthetic NDVI and support vector machine (SVM) techniques were integrated to develop an AGB estimation model (SVM-AGB) for Xilinhot in Inner Mongolia, China. Compared with model generated from MODIS-NDVI (R2 = 0.73, root-mean-square error (RMSE) = 30.61 g/m2), the SVM-AGB model we developed can not only ensure the accuracy of estimation (R2 = 0.77, RMSE = 17.22 g/m2), but also produce higher spatial (30 m) and temporal resolution (8-d) biomass maps. We then generated the time-series biomass to detect biomass anomalies for grassland regions. We found that the synthetic NDVI-derived estimations contained more details on the distribution and severity of vegetation anomalies compared with MODIS NDVI-derived AGB estimations. This is the first time that we have generated time series of grassland biomass with 30-m and 8-d intervals data through combined use of a data-fusion method and the SVM-AGB model. Our study will be useful for near real-time and accurate (improved resolutions) monitoring of grassland conditions, and the data have implications for arid and semi-arid grasslands management.
User Validation of VIIRS Satellite Imagery
Authors: Hillger Don , Kopp Tom , Seaman Curtis , Miller Steven , Lindsey Dan , Stevens Eric , Solbrig Jeremy , Straka III William , Kreller Melissa , Kuciauskas Arunas , Terborg Amanda
Published: December 2015

Visible/Infrared Imaging Radiometer Suite (VIIRS) Imagery from the Suomi National Polar-orbiting Partnership (S-NPP) satellite is the finest spatial resolution (375 m) multi-spectral imagery of any operational meteorological satellite to date. The Imagery environmental data record (EDR) has been designated as a Key Performance Parameter (KPP) for VIIRS, meaning that its performance is vital to the success of a series of Joint Polar Satellite System (JPSS) satellites that will carry this instrument. Because VIIRS covers the high-latitude and Polar Regions especially well via overlapping swaths from adjacent orbits, the Alaska theatre in particular benefits from VIIRS more than lower-latitude regions. While there are no requirements that specifically address the quality of the EDR Imagery aside from the VIIRS SDR performance requirements, the value of VIIRS Imagery to operational users is an important consideration in the Cal/Val process. As such, engaging a wide diversity of users constitutes a vital part of the Imagery validation strategy. The best possible image quality is of utmost importance. This paper summarizes the Imagery Cal/Val Team’s quality assessment in this context. Since users are a vital component to the validation of VIIRS Imagery, specific examples of VIIRS imagery applied to operational needs are presented as an integral part of the post-checkout Imagery validation.