bluuebunny/crossref_metadata_2025 huggingface dataset:
High‐grade transformation of pancreatic neuroendocrine tumor associated with TP53 mutations: A diagnostic pitfall mimicking neuroendocrine carcinoma
Authors: Tanaka Mariko , Shinozaki‐Ushiku Aya , Kunita Akiko , Yasunaga Yoichi , Akamatsu Nobuhisa , Hasegawa Kiyoshi , Ushiku Tetsuo
Published: June 2022

Among pancreatic neuroendocrine neoplasms, mutations in ATRX, DAXX, and MEN1 are specific to neuroendocrine tumors (NETs), whereas TP53 and RB1 mutations are characteristic of neuroendocrine carcinomas (NECs). We report a case of pancreatic NET that underwent high‐grade transformation associated with acquisition of TP53 mutations. The primary pancreatic tumor consisted of conventional grade 2 NET with loss of alpha‐thalassemia/mental retardation, X‐linked expression and wild‐type TP53, with a small focus exhibiting significant pleomorphism and increased mitotic activity of the neoplastic cells with two pathogenic TP53 mutations. Two years later, multiple liver metastases developed and were surgically resected. The metastatic tumors showed marked pleomorphism with increased mitotic activity (17/2 mm2) and TP53 mutations identical to the small area with TP53 mutations in the primary tumor. Liver metastases with a single TP53 mutation were also noted. Notably, hormonal phenotype has changed during progression with decreased glucagon and increased insulin expression in the metastases. Our observations suggest that TP53 mutation can occur in pancreatic NETs during progression and can be associated with phenotypic transformation. Importantly, increased pleomorphism, mitotic activity, as well as TP53 mutations could be diagnostic pitfalls leading to an overdiagnosis of NEC.
Arabidopsis ABCG27 plays an essential role in flower and leaf development by modulating abscisic acid content
Authors: Kim Kyungyoon , Choi Bae Young , Kang Joohyun , Shim Donghwan , Martinoia Enrico , Lee Youngsook
Published: June 2022

Abscisic acid (ABA) is a phytohormone that mediates stress responses and regulates plant development. Several ATP‐binding cassette (ABC) transporters in the G subfamily of ABC (ABCG) proteins have been reported to transport ABA. We investigated whether there are any other ABCG proteins that mediate plant developmental processes regulated by ABA in Arabidopsis (Arabidopsis thaliana). The ABCG27 gene was upregulated in response to exogenous ABA treatment. The abcg27 knockout mutant exhibited two developmental defects: epinastic leaves and abnormally long pistils, which reduced fertility and silique length. ABCG27 expression was induced threefold when flower buds were exposed to exogenous ABA, and the promoter of ABCG27 had two ABA‐responsive elements. ABA content in the pistil and true leaves were increased in the abcg27 knockout mutant. Detached abcg27 pistils exposed to exogenous ABA grew longer than those of the wild‐type control. ABCG27 fused to GFP localized to the plasma membrane when expressed in Arabidopsis mesophyll protoplasts. A transcriptome analysis of the pistils and true leaves of the wild type and abcg27 knockout mutant revealed that the expression of organ development‐related genes changed in the knockout mutant. In particular, the expression of trans‐acting small interference (ta‐si) RNA processing enzyme genes, which regulate flower and leaf development, was low in the knockout mutant. Together, these results suggest that ABCG27 most likely function as an ABA transporter at the plasma membrane, modulating ABA levels and thereby regulating the development of the pistils and leaves under normal, non‐stressed conditions.
Gene editing in porcine embryos using a combination of electroporation and transfection methods
Authors: Takebayashi Koki , Wittayarat Manita , Lin Qingyi , Hirata Maki , Yoshimura Naoaki , Torigoe Nanaka , Nagahara Megumi , Do Lanh Thi Kim , Tanihara Fuminori , Otoi Takeshige
Published: June 2022

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeats‐CRISPR‐associated protein 9) technology is growing rapidly and has been greatly influencing the efficiency and effectiveness of genetic modifications in different applications. One aspect of research gaining importance in the development of the CRISPR/Cas9 system is the introduction of CRISPR materials into target organisms. Although we previously demonstrated the efficacy of electroporation‐ and lipofection‐mediated CRISPR/Cas9 gene disruption in porcine zygotes, we still believe that the efficiency of this system could be improved by combining these two methods. The present study was thus conducted to clarify the effects of a combination of electroporation and lipofection for delivering CRISPR/Cas9 components into zona pellucida (ZP)‐intact and ‐free zygotes. The results revealed that electroporation alone significantly increased the biallelic mutation rates in the resulting blastocysts compared to lipofection alone, irrespective of the presence of ZP. None of ZP‐intact zygotes treated by lipofectamine alone had any mutations, suggesting that removal of the ZP is necessary for enabling CRISPR/Cas9‐based genome editing via lipofection treatment in the zygotes. Additional lipofectamine treatment after electroporation did not improve the rates of total and biallelic mutations in the resulting blastocysts derived from either ZP‐intact or ‐free zygotes.
The prospect of targeting T cell immunoglobulin and mucin‐domain containing‐3 in renal cell carcinoma immunotherapy
Authors: Mohsenzadegan Monireh , Nowroozi Mohammad Reza , Fotovvat Amirreza , Bavandpour Baghshahi Parizad , Bokaie Saied , Inanloo Seyed Hassan , Sharifi Laleh
Published: June 2022

Despite the advances in the diagnosis and treatment of renal cell carcinoma (RCC), it remains one of the most deadly urological cancers. At present, using immune checkpoint inhibition and their combination with antiangiogenic therapy is the standard of care in patients with advanced RCC. Unfortunately, a considerable part of tumour‐bearing hosts does not benefit from this type of treatment. However, our knowledge about the detailed role of mucin‐domain containing‐3 (TIM‐3) in the RCC cells is little, and further studies are required in this field, but its significant expression in the RCC microenvironment makes this receptor a promising target for designing new monoclonal antibodies alone or in combination with other checkpoint inhibitors for RCC immunotherapy.
Impact of societal and legal context on the blood supply of African‐ancestry populations in Western countries: A review of practices and the French example
Authors: Oviedo Pauline , Jaffré Yannick , Danic Bruno , Mazières Stéphane , Chiaroni Jacques
Published: June 2022

In Western countries, blood supply agencies encounter impediments in providing blood groups defined as rare or of interest, notably for sub‐Saharan African ancestry (SSAA) recipients. To establish warning levels and anticipate future blood needs, an estimate of the current carriers of rare blood groups, both potential patients or donors, is crucial but complex. Indeed, if the strict needs can be estimated in medical terms, the modalities of blood product collection must be considered from an interdisciplinary perspective, at the interface of biological data and social norms. Here, we aim to understand how legal choices and a set of representations of otherness may influence the supply of rare blood for SSAA populations. After examining these issues, considering different norms and limits that govern French society, we compare this data with those of four Western countries facing the same difficulties (United States, United Kingdom, Italy and the Netherlands). This work began as part as the reflections of Social Lab, an institutional programme created by the French Blood Establishment (EFS). How can we effectively improve the qualitative blood coverage for SSAA populations? There is no unique solution, but there are many more or less effective answers. Comparison across countries reveals a strong influence of the socio‐political histories and ethical choices before technical and medical considerations. We consider that an institutional policy is required to resolve recruitment issues of SSAA donors sustainably. Lastly, we introduce a working group called the EFS Social Lab, which aims to set up a monitoring mechanism for donors and societal trends to make blood donation effective.
A Third-Order Two-Stage Numerical Scheme for Fractional Stokes Problems: A Comparative Computational Study
Authors: Nawaz Yasir , Arif Muhammad Shoaib , Abodayeh Kamaleldin
Published: June 2022

A third-order numerical scheme is proposed for solving fractional partial differential equations (PDEs). The first explicit stage can converge fast, and the second implicit stage is responsible for enlarging the stability region. The fourth-order compact scheme is employed to discretize spatial derivative terms. The stability of the scheme is given for the standard fractional parabolic equation, whereas convergence of the proposed scheme is given for the system of fractional parabolic equations. Mathematical models for heat and mass transfer of Stokes first and second problems using Dufour and Soret effects are given in a set of linear and nonlinear PDEs. Later on, these governing equations are converted into dimensionless PDEs. It is shown that the proposed scheme effectively solves the fractional forms of dimensionless models numerically, and a comparison is also conducted with existing schemes. If readers want it, a computational code for the discrete model system suggested in this paper may be made accessible to them for their convenience.
Field attenuation characteristics of hearing protectors and differences in estimating their attenuation with different methods
Authors: Gong Wei , Xu Yanqiong , Liu Yufei
Published: June 2022

This study investigated the field attenuation characteristics of hearing protection devices (HPDs), differences in estimating the protection provided by HPDs with different rating methods, and suggested potential solutions on proper use of attenuation ratings to estimate the protection provided by HPDs. The binaural octave-band personal attenuation values obtained from 1583 field users with 3985 fits on seven HPDs were used to compute the field-rating values as described in the International Organization for Standardization standard ISO 4869-2:2018, and the octave-band noise reduction (OB NR) values of each fit for 100 noises. The estimated protection for 100 noises was compared within different rating methods. The OB NR values varied with quality of fit, noise spectra, and HPD. The quality of fit was a crucial factor. Deviations in estimating the protection given by different rating methods varied with HPD and quality of fit. The misuse of subtracting the single number rating (SNR) from A-weighted noise level magnified these deviations. The multiple-number rating gave a more accurate estimation of protection provided by the earmuff compared to SNR. Improving the quality of fit and including C-weighted noise level can reduce the variability and deviation in protection estimation for different noises.
Unexpected fish and squid in the central Arctic deep scattering layer
Authors: Snoeijs-Leijonmalm Pauline , Flores Hauke , Sakinan Serdar , Hildebrandt Nicole , Svenson Anders , Castellani Giulia , Vane Kim , Mark Felix C. , Heuzé Céline , Tippenhauer Sandra , Niehoff Barbara , Hjelm Joakim , Hentati Sundberg Jonas , Schaafsma Fokje L. , Engelmann Ronny ,   The EFICA-MOSAiC Team
Published: June 2022

The retreating ice cover of the Central Arctic Ocean (CAO) fuels speculations on future fisheries. However, very little is known about the existence of harvestable fish stocks in this 3.3 million–square kilometer ecosystem around the North Pole. Crossing the Eurasian Basin, we documented an uninterrupted 3170-kilometer-long deep scattering layer (DSL) with zooplankton and small fish in the Atlantic water layer at 100- to 500-meter depth. Diel vertical migration of this central Arctic DSL was lacking most of the year when daily light variation was absent. Unexpectedly, the DSL also contained low abundances of Atlantic cod, along with lanternfish, armhook squid, and Arctic endemic ice cod. The Atlantic cod originated from Norwegian spawning grounds and had lived in Arctic water temperature for up to 6 years. The potential fish abundance was far below commercially sustainable levels and is expected to remain so because of the low productivity of the CAO.
Time for Some Group Therapy: Update on Identification, Antimicrobial Resistance, Taxonomy, and Clinical Significance of the Bacteroides fragilis Group
Authors: Jean Sophonie , Wallace Miranda J. , Dantas Gautam , Burnham Carey-Ann D.
Published: June 2022

Bacteroides fragilis
group (BFG) species are common members of the human microbiota that provide several benefits to healthy hosts, yet BFG are also the most common anaerobes isolated from human infections, including intra-abdominal infections, abscesses, and bloodstream infection. Compared to many other anaerobes associated with disease, members of the BFG are more likely to be resistant to commonly used antimicrobials, including penicillin (>90% resistant), carbapenems (2 to 20% resistant), and metronidazole (0.2 to 4% resistant).
Longitudinal Assessment of SARS-CoV-2-Specific T Cell Cytokine-Producing Responses for 1 Year Reveals Persistence of Multicytokine Proliferative Responses, with Greater Immunity Associated with Disease Severity
Authors: Lin Jonah , Law Ryan , Korosec Chapin S. , Zhou Christine , Koh Wan Hon , Ghaemi Mohammad Sajjad , Samaan Philip , Ooi Hsu Kiang , Matveev Vitaliy , Yue FengYun , Gingras Anne-Claude , Estacio Antonio , Buchholz Megan , Cheatley Patti Lou , Mohammadi Avid , Kaul Rupert , Pavinski Katerina , Mubareka Samira , McGeer Allison J. , Leis Jerome A. , Heffernan Jane M. , Ostrowski Mario
Published: June 2022

Our findings highlight the relative importance of SARS-CoV-2-specific GzmB-producing T cell responses in SARS-CoV-2 control and shared CD4 and CD8 immunodominant epitopes in seasonal coronaviruses or SARS-CoV-1, and they indicate robust persistence of T cell memory at least 1 year after infection. Our findings should inform future strategies to induce T cell vaccines against SARS-CoV-2 and other coronaviruses.
AI-2/LuxS Quorum Sensing System Promotes Biofilm Formation of Lactobacillus rhamnosus GG and Enhances the Resistance to Enterotoxigenic Escherichia coli in Germ-Free Zebrafish
Authors: Deng Zhaoxi , Hou Kangwei , Valencak Teresa G. , Luo Xin M. , Liu Jianxin , Wang Haifeng
Published: June 2022

Lactobacillus rhamnosus
GG is a widely used probiotic to improve host intestinal health, promote growth, reduce diarrhea, and modulate immunity. In recent years, the bacterial quorum sensing system has attracted much attention; however, there has not been much research on the effect of the LuxS/AI-2 quorum sensing system of
Lactobacillus
on bacteriostasis, microbial ecology balance, and immune regulation in intestine.
Evaluation of Aptamer Fluorescence Microscopy in the Diagnosis of Pulmonary Tuberculosis
Authors: Zheng Ruijuan , Xu Feifan , Huang Xiaochen , Wang Jie , Feng Yonghong , Huang Jin , Qin Lianhua
Published: June 2022

We established an aptamer fluorescence microscopy approach for rapid detection of MTB in clinical sputum samples. The use of aptamer probes was proven to significantly increase the sensitivity of sputum smear microscopy.
Strong Coupling and Rabi Oscillations in GaAs/AlGaAs Heterostructures as a Result of Electron–Hole Pair Condensation at Room Temperature
Authors: Vasil’ev P. P.
Published: June 2022

The experimental results of the investigation of coherent terahertz oscillations of the electromagnetic field from GaAs/AlGaAs heterostructures during the superradiant pulse generation have been presented. Optical doublets, which are typical for Rabi oscillations, with the splitting of 1.3–4.4 meV at 860–890 nm wavelengths have been discovered. The corresponding coherent oscillations in the time domain have been detected. The effect has been only observed in the strong coupling regime of the field with the electron–hole system. It has been demonstrated that it is the condensation of e–h pairs in phase space that makes the strong coupling p-ossible in the present experimental conditions. The experimental result is yet another convincing evidence of the e–h condensation in bulk GaAs at room temperature, which has been discussed in our previous publications.
Reusable Proline-Containing Bimetallic Pd–Ni(Co, Cu, Fe)–Pro/Al2O3 Catalysts for Suzuki Reaction in Water
Authors: Bumagin N. A.
Published: June 2022

Bimetallic proline-containing composites Pd–Ni(Co, Cu, Fe)–Pro/Al2O3, due to the synergistic effect, exhibit high catalytic activity in the Suzuki reaction in aqueous media, which makes it possible to reduce the amount of expensive Pd to 10–2 mol %. New catalysts are easily regenerated from the reaction mixture and can be reused up to 5 times without losing activity.
The inclusion of health in major global reports on climate change and biodiversity
Authors: Dasandi Niheer , Cai Wenjia , Friberg Peter , Jankin Slava , Kuylenstierna Johan , Nilsson Maria
Published: June 2022

This article argues that human health has become a key consideration in recent global reports on climate change and biodiversity produced by various international organisations; however, greater attention must be given to the unequal health impacts of climate change and biodiversity loss around the world and the different health adaptation measures that are urgently required.
Qualitative analysis of the organisational response of a university hospital during the first wave of the COVID-19 crisis
Authors: Harkouk Hakim , Castel Patrick , Hervouët Lucile , Fletcher Dominique
Published: June 2022

Background

The COVID-19 pandemic has required urgent organisational and managerial adaptation, with hospital medical and administrative leaders under considerable pressure.

Methods

At a single French university hospital, we performed a sociological analysis of management adaptation by medical and administrative leaders during the first wave of the COVID-19 crisis. Two sociologists performed interviews with representative members of staff from all the structures involved in managing the crisis to analyse adaptation and the solutions found during this period.

Results

The answers collected during interviews were classified into three main topics describing the organisational adaptations of the hospital staff during the COVID-19 crisis: (1) exceptional mobilisation and collaboration; (2) crisis management based primarily on the principle of subsidiarity; and (3) survival of the administrative structure with interventions to support caregivers.

Conclusion

This study, focusing on a single hospital, identified a number of factors associated with successful mobilisation in the very specific conditions of this viral pandemic.
Delayed collapse of flow diverter due to acute severe vasospasm: another concern for flow diversion in ruptured aneurysms
Authors: Kumar Ajay , Choudhary Neha , Prabhakar Anuj , Bhatia Vikas
Published: June 2022

In vivo morphological change of flow diverter stents (FDS) is a known phenomenon and can be seen secondary to various device- and vasculature-related factors such as improper sizing of the device, twisting of the device in tortuous anatomy, insufficient proximal landing zone, and insufficient chronic resistive force of the stent, etc. However, we have encountered a case where severe vasospasm due to aneurysmal subarachnoid hemorrhage led to the collapse of the proximal end of the FDS. Development of vasospasm and consequent possible failure of the device should be taken into consideration when planning flow diversion in ruptured aneurysms.
Survey on the metric SYZ conjecture and non-Archimedean geometry
Authors: Li Yang
Published: June 2022

We survey the metric aspects of the Strominger–Yau–Zaslow conjecture on the existence of special Lagrangian fibrations on Calabi–Yau manifolds near the large complex structure limit. We will discuss the diverse motivations for the conjectural picture, what the best hopes are, and a number of subtleties. The bulk of the survey highlights the role of pluripotential theory, and non-Archimedean geometry in particular, with a list of open questions.
Bifurcation of Dividing Surfaces Constructed from Period-Doubling Bifurcations of Periodic Orbits in a Caldera Potential Energy Surface
Authors: Katsanikas Matthaios , Agaoglou Makrina , Wiggins Stephen
Published: June 2022

In this work we analyze the bifurcation of dividing surfaces that occurs as a result of two period-doubling bifurcations in a 2D caldera-type potential. We study the structure, the range, the minimum and maximum extents of the periodic orbit dividing surfaces before and after a subcritical period-doubling bifurcation of the family of the central minimum of the potential energy surface. Furthermore, we repeat the same study for the case of a supercritical period-doubling bifurcation of the family of the central minimum of the potential energy surface. We will discuss and compare the results for the two cases of bifurcations of dividing surfaces.
Stability and Bifurcation Analysis of a Discrete Severe Fever with Thrombocytopenia Syndrome Model
Authors: Lin Jia-Yi , Zhang Xue
Published: June 2022

Severe fever with thrombocytopenia syndrome (SFTS) is an acute tick-borne disease caused by SFTS virus (SFTSV). In this paper, we use difference equations to establish a discrete tick-borne disease model with systemic and transovarial transmission. Using the method of the next generation of matrix, we get the basic reproduction number [Formula: see text] to determine whether SFTS will die out. Furthermore, we analyze the existence and stability of equilibrium points by [Formula: see text]. In addition, the transcritical bifurcation property at the disease-free equilibrium point is discussed by deriving a equation describing the flow on the center manifold. Finally, we perform numerical simulations to verify the theoretical results.
Multiple Time-Scales Dynamics of a Cardiac Pacemaker Model with Application to Heart Rhythm Modeling: Theoretical Study and FPGA Implementation
Authors: Gildas Kuate Guy Chance , Mabekou Takam Jeanne Sandrine , Ngagoum Tchamdjeu Frank Xavier , Fotsin Hilaire Bertrand
Published: June 2022

The aim of this work is to investigate the nonlinear dynamics of a forced cardiac pacemaker model represented by a forced modified van der Pol oscillator by using the method of harmonic balance and the method of multiple time scales. The amplitudes of the forced harmonic, primary resonant state, super-harmonic and sub-harmonic resonant state oscillations are obtained and the effects of some system parameters on these amplitudes are investigated; hysteresis and jump phenomena are found. Three similar oscillators are then coupled together via time-delay coupling to model the heart rhythm and the effect of the coupling factor and time delay is also investigated. The overall model is then discretized using the fourth-order Runge–Kutta algorithm. A corresponding very high-speed integrated circuit hardware description language code is then written, synthesised and implemented using the Vivado-2017.4 software for the Artix7-xc7a35tftg256-1 field programmable gate array chip. The chip statistics, time series electrocardiograms and phase portraits of the model are derived; a good correlation between theoretical results (obtained with MATLAB program and Vivado software) and practical results is observed.
EFFECTS OF POINT GRINDING SURFACE TEXTURE ON CONTACT AND WEAR CHARACTERISTICS UNDER DRY SLIDING CONDITION
Authors: CHAO CAIXIA , WANG YAN , XIU SHICHAO
Published: June 2022

The main objective of this work is to study the effects of surface texture direction on contact and wear characteristics of point grinding parts under dry sliding contact. This study provided a method to obtain the surface with good contact characteristics and wear resistance under certain working conditions. The point grinding surface texture model, the contour support length model considering surface texture, and the fractal contact model of the cylindrical surface were built. The measuring experiment was carried out using TR300 roughness shape measuring instrument and the tribological experiment was carried out using HSR-2M high-speed reciprocating friction and wear tester. The results showed that the surface texture direction had an effect on the contour support length ratio, the contact and wear characteristics of parts. When the surface texture direction angle was 30∘, the average friction coefficient was the smallest, the supporting performance and wear resistance of parts were the best; for surfaces with 30∘ and 60∘ texture, the fluctuation of the friction coefficients was smaller, the wear uniformity was better; when the load was small, the abrasion loss of point grinding parts will decrease with increase in the direction angle of surface texture. The results can help to choose appropriate processing method and machining parameters to obtain appropriate surface.
Existence of traversable wormholes with varied shape functions in f(ℛ2,𝒯 ) gravity
Authors: Ahmed Riaz , Abbas G. , Nazar H. , Iqbal K.
Published: June 2022

In this paper, we derive the exact solution of traversable wormholes illustrating spherically symmetric geometry with anisotropic matter distribution entering the throat in the formalism of [Formula: see text] gravity, where [Formula: see text] is Ricci scalar and [Formula: see text] is trace of energy–momentum tensor. For this purpose, we assume a power law-type generic function [Formula: see text], where [Formula: see text] and [Formula: see text] are being constants, with two different choices of shape functions [Formula: see text] and [Formula: see text]. For each approach, we find the exact solution and studied the existence of wormhole solutions in the presence of exotic and non-exotic matter. The graphical behavior of equation of state (EoS) parameter and energy condition bounds is also investigated for each shape function. The realistic wormhole solutions are obtained for the shape functions which satisfy necessary conditions at the throat radius [Formula: see text]. Finally, we observe that there is small deviation in the results obtained by General Relativity and [Formula: see text] gravity.
Conformal structure of quantum wave mechanics
Authors: Petti Richard James
Published: June 2022

This work interprets the quantum terms in a Lagrangian, and consequently of the wave equation and momentum tensor, in terms of a modified spacetime metric. Part I interprets the quantum terms in the Lagrangian of a Klein–Gordon field as scalar curvature of conformal dilation covector nm that is proportional to [Formula: see text] times the gradient of wave amplitude R. Part II replaces conformal dilation with a conformal factor [Formula: see text] that defines a modified spacetime metric [Formula: see text]= exp[Formula: see text], where g is the gravitational metric. Quantum terms appear only in metric [Formula: see text] and its metric connection coefficients. Metric [Formula: see text] preserves lengths and angles in classical physics and in the domain of the quantum field itself. [Formula: see text] combines concepts of quantum theory and spacetime geometry in one structure. The conformal factor can be interpreted as the limit of a distribution of inclusions and voids in a lattice that cause the metric to bulge or contract. All components of all free quantum fields satisfy the Klein–Gordon equation, so this interpretation extends to all quantum fields. Measurement operations, and elements of quantum field theory are not considered.
The matrices of Pauli quaternions, their De Moivre’s and Euler’s formulas
Authors: Akbıyık Mücahit , Yamaç Akbıyık Seda , Yılmaz Fatih
Published: June 2022

In this paper, we obtain Euler’s and De Moivre’s formulas for the [Formula: see text] matrix representation of Pauli quaternions. Moreover, we provide De Moivre’s formula for the light-like Pauli quaternions. Additionally, we give the nth roots of the matrix representation of Pauli quaternions. Moreover, we exemplify some of the results with illustrative examples to support the main formulas.
Predictive Analysis of Hospital HIS System Usage Satisfaction Based on Machine Learning
Authors: Hu Yuhang , Gan Haotian
Published: June 2022

Hospital information system (HIS) can provide a full range of information support for various hospital business activities and information collection, processing, and transmission, helping medical service providers. And HIS can reduce medical service costs and improve work efficiency, greatly reducing errors in diagnosis and treatment. Although the advantages of using the HIS are obvious, there are still some challenges in its use, the most prominent being how to make the medical staff use HIS effectively. Based on this background, this paper uses machine learning (ML) technology to predict and analyze the satisfaction of HIS use in hospitals and completes the following work: firstly, introduce the situation and development trend of HIS construction at home and abroad and provide theoretical basis for model design. The related development technologies are discussed and studied in detail. Second, the ML algorithm is used to provide a prediction strategy. The support vector machine (SVM) can handle small data sets well, and this study applies the AdaBoost technique to improve the model’s generalization ability and accuracy. Lastly, a diversity metric is included to guarantee that the basic learner has good variety in order to increase the algorithm’s performance. Accuracy rates may reach more than 95% in the case of tiny data sets, according to the self-built data set used for testing. This proves the superiority of the model proposed in this paper.
A New Damage Model of Rock Considering Residual Strength under Seepage Pressure
Authors: Zhilei He
Published: June 2022

Seepage pressure changes the rock structure and stress state, inducing rock mass damage and destruction under hydromechanical coupling. To describe the deformation characteristic and the entire stress–strain process, we suppose that rock consists of damaged part, undamaged part, and voids part. The three parts are intermingled to carry external loads and the undamaged part gradually becomes damaged part in compression. A redefinition of the damage variable and evolution equation is proposed incorporating damage mechanics and statistical damage theory. Considering that axial loads of the damage parts equal to residual strength, a new statistical damage softening constitutive model is developed. The model is validated by using the experimental data. The proposed model can reflect the entire stress–strain law very well, especially softening deformation characteristics after the peak. The research results are helpful in the rock mass engineering safety analysis under seepage pressure.
Field Test and Data Simulation of Foundation Pit Support System Based on BP Neural Network
Authors: Chen Fei , Wang Han
Published: June 2022

In view of the neural network problem, a field test and data simulation study of the root pit support system is proposed. First, in some difficult cases, the BP algorithm is usually due to the low level of training, thus changing the tuition and fees. Second, the BP algorithm can mix heavy objects with special effects, but the gradient process will generate local minima, so the minimum error cannot be guaranteed. The experimental response and simulation data of the BP neural network foundation pit support system is analyzed, and all experimental data are recorded. Finally, from an empirical point of view, the results brought by the field test of the central support system are determined and ultimately, promote the development of human life. The genetics-based estimation algorithm reproduces the neural network, the estimation time is 10 s, the prediction error root floats between −0.05–0.05 mm, the maximum correlation near error is 0.36%, and the approximate IA value is higher than 0.9.
Effect of Routine Therapy Assisted by Physical Exercise on Pulmonary Function in Patients with Asthma in Stable Stage: A Systematic Review and Meta-analysis of Randomized Clinical Trials
Authors: Li Xionghui , Mao Chengye , Pan Yunchang
Published: June 2022

Objective. This study is aimed at investigating the efficacy of physical exercise-assisted routine therapy on the pulmonary function of patients with stable asthma to provide clinical evidence and data support to guide disease management. Methods. Randomized controlled clinical trials of drug therapy and/or physical exercise for patients with stable asthma were retrieved from the China National Knowledge Infrastructure (CNKI), Wanfang database, Embase, PubMed, and Web of Science database. The studies published between January 2000 and June 2021 that met the criteria were included, and corresponding data were extracted. The meta-analysis was performed using the statistical software Stata 16.0. Statistical pooled effect sizes and 95% confidence intervals were calculated using a random-effects or fixed-effects model, as funnel plots were made with Begg’s rank correlation method to evaluate publication bias. Result. This meta-analysis included 14 randomized controlled studies. Physical exercise-assisted treatment (experiment group) or routine therapy was associated with significantly elevated levels of forced expiratory volume in 1 second (FEV1) and forced vital capacity (FVC) (

P
<
0.05

). As for the peak expiratory flow (PEF) level (

P
<
0.05

), its level was significantly increased with physical exercise-assisted therapy compared with the conventional approach (

P
>
0.05

). Subgroup analysis indicated that the FVC level in the experimental group was higher than that in the control group (

P
<
0.05

) regardless of the adoption of aerobic exercise/anaerobic exercise. In regard to the FEV1 and PEE levels, aerobic exercise was associated with elevated levels in the experimental group (

P
<
0.05

), while no significant difference in anaerobic exercise between both groups was observed (

P
>
0.05

). Further, FEV1, FVC, and PEF levels in the experimental group were higher than those receiving conventional treatment in the control group (

P
<
0.05

). Conclusion. Routine treatment combined with physical exercise could improve the levels of FEV1, FVC, and PEF in patients with bronchial asthma in the nonacute attack stage and enhance pulmonary functions. As a safe and efficient adjuvant therapy, physical exercise can contribute to an improved prognosis and quality of life for patients with asthma.
Research on the Strategy of Autonomous Learning under the Dual-Class Model of Ideological and Political Courses Based on the Knowledge Map Route
Authors: Shi PeiShuang
Published: June 2022

The two-part classroom teaching mode organically combines teachers’ lectures with students’ discussions, which can not only ensure the dominance of ideological and political teachers’ classroom teaching but also give full play to students’ autonomy in learning. The role of students’ autonomous learning as a bridge between teachers’ lectures and students’ discussions cannot be ignored. Through the study of the knowledge map, the self-learning strategies of ideological and political courses calculated from the aspects of resource push and path planning, accurate learning resource search, in-depth reading, and answering robots will maximize the benefits of students’ self-learning.
Effects of Low-Flux and High-Flux Dialysis Membranes on Erythropoietin Responsiveness in Hemodialysis Patients
Authors: Abdelhamid Walid A. R. , Soliman Mohamed M. , El-Hameed Ayman R. A.
Published: June 2022

Background. Chronic kidney disease (CKD) is often accompanied by anemia. High-flux membranes contribute to a reasonable removal of uremic toxins which cause anemia in CKD. Inadequate data have described the efficiency of high-flux dialysis in promoting erythropoietin responsiveness in CKD patients in the Middle East. This study was conducted to compare the efficiency of maintaining high-flux hemodialysis versus low-flux dialysis for ≥1 year in promoting erythropoietin responsiveness and to show the factors associated with erythropoietin hyporesponsiveness in Arab chronic hemodialysis patients. Methods. It was a retrospective cohort study that involved 110 subjects who were categorized into group 1 (50 patients receiving low-flux dialysis) and group 2 (60 patients receiving high-flux dialysis). History taking, examination, and laboratory investigations were conducted for all patients every 3 months from January 2021 to January 2022. Results. Group 2 had significantly higher weight and body mass index than group 1 but lower cholesterol and intact parathyroid hormone levels than group 1. Erythropoietin resistance index levels did not differ between the two groups upon repeated measures over a 1-year follow-up. Significant risk factors for erythropoietin hyporesponsiveness on multivariate analysis were lower weight (Odds ratio (OR): 0.966; 95% Confidence interval (CI): 0.94–0.992;

p
=
0.011

), longer hemodialysis vintage (OR: 1.172; 95% CI: 1.036–1.325;

p
=
0.012

), lower hemoglobin levels (OR: 0.531; 95% CI: 0.362–0.779;

p
=
0.001

), and higher neutrophil-to-lymphocyte ratio (OR: 2.436; 95% CI: 1.321–4.493;

p
=
0.004

). Conclusion. High-flux dialysis was not superior to low-flux dialysis in improving erythropoietin responsiveness.
Blast Liquefaction Test of Saturated Sand Foundations Disposed by a Drainage Rigid Pile
Authors: Ni Songtao , Chen Yumin , Chen Runze , Liu Hanlong , Li Changchun , Hu Shaobin
Published: June 2022

Drainage rigid piles represent a commonly used antiliquefaction treatment for saturated sand foundations. Small-scale model tests on the liquefaction-resistant characteristics of drainage rigid piles subjected to blasting were conducted in this study. The effect of ordinary rigid piles and drainage rigid piles on the disposal of saturated sand foundations was investigated by using carbon dioxide (CO2) fracturing to generate explosive vibratory loads. The test results showed that the blast vibration load increased the relative density of the site by approximately 10% and that the relative density was proportional to the burial depth. The site vertical acceleration attenuations resulting from the two blasts were 35% and 45%, respectively, and the variation pattern of vertical acceleration on both sides of drainage rigid piles and ordinary piles is similar. Drainage rigid piles can dissipate more than 70% of the excess pore water pressure under liquefaction and can quickly accumulate excess pore water pressure and, likewise, quickly dissipate excess pore water pressure. The higher the excess pore water pressure at a site is, the more effective the disposal by a drainage rigid pile is. This field test provides a design reference for the engineering application of drainage rigid piles.
College Vocal Music Teaching Design Based on Internet Platform
Authors: Tang Meng-Meng
Published: June 2022

Internet has penetrated into people’s lives as the Internet education platform has faced many changes in the way vocal music is taught in the new situation. The teaching methods set up on the Internet have also undergone dramatic changes. A number of advanced music education concepts have emerged that require a careful review of the current state of music education in the world and in China. Current online learning environments are usually used only for formal or informal learning. The former overemphasizes the subjective role of the teacher and ignores the autonomy of the learner. Through a new modern network education method, this paper deeply analyzes the unique advantages and existing problems of a new voice education method based on the Internet and puts forward corresponding solutions. Its purpose is to encourage more ordinary vocal music teachers to better understand the new teaching methods, broaden their artistic horizons, consciously use modern teaching methods to support vocal music education in ordinary schools, and further expand the scope of music application. The experimental results show that for 4000 concurrent users, the response time of the system is less than 5 seconds, which can meet the time requirements of the system. For the service of querying some other data, the response time of the system is less than 9 seconds, so the response ability of the system to multiple users is impressive. Therefore, with the development of education, comprehensive network education platform is also the development direction of informatization in the future.
Nigella sativa Oil Reduces LPS-Induced Microglial Inflammation: An Evaluation on M1/M2 Balance
Authors: Hosseini Azar , Baradaran Rahimi Vafa , Rakhshandeh Hassan , Askari Vahid Reza
Published: June 2022

Objectives. The immune system plays a critical defence role against infections, injuries, and carcinogenic stimuli. As the macrophages of the brain resides in the innate immune system, microglia and their polarisation (M1/M2) play regulatory roles in inflammation in CNS, such as Parkinson’s, Alzheimer’s, dementia complex, and multiple sclerosis. Nigella sativa belongs to the Ranunculaceae family and has different anti-inflammatory and antioxidant effects. We conducted this study to evaluate the anti-inflammatory and protective properties of N. sativa oil (NSO) on the microglial cells and their polarisation (M1/M2) in the presence of LPS as a model of neuroinflammation. Methods. The protective effects of NSO (10–40 µg/ml) were studied on the LPS-induced microglial cells, and the levels of tumour necrosis factor-α (TNF-α), interleukin-1β (IL-1β), IL-6, prostaglandin E2 (PGE2), and IL-10 were evaluated using both ELISA and gene expression methods. The levels of cyclooxygenase-2 (COX-2), inducible NOS (iNOS), and arginase-1 (Arg1) were also evaluated using the real-time PCR method. In addition, nitrite oxide (NO) and urea were measured using biochemical methods. Results. NSO decreased LPS-induced toxicity at all doses (P < 0.001). NSO (10–40 μg/ml) also significantly reduced the levels of TNF-α, PGE2, IL-1β, and IL-6 in the presence of LPS (P < 0.01 to 0.001). Pretreatment with NSO attenuated the levels of iNOS but increased Arg1 (P < 0.001). The ratio of iNOS/Arg1 was also decreased in the presence of NSO (P < 0.001) than that of the LPS group (P < 0.001). Conclusion. NSO attenuated LPS-induced inflammation and increased microglia’s anti-inflammatory status. These results may prove that NSO is potentially an immunomodulator for various neurodegenerative diseases by M1 phenotype dominancy, such as Alzheimer’s and Parkinson’s diseases.
Correlation of Computed Tomographic Angiography in Patients Undergoing Coronary Artery Bypass Grafting and Effect of Standardized Rehabilitation Nursing
Authors: Liu Mingming
Published: June 2022

This study aimed to explore the clinical application of computed tomographic angiography (CTA) and standardized rehabilitation nursing in patients with coronary artery bypass grafting (CABG). CTA image was segmented by reconstruction algorithm and finally assembled into a whole image. Three-dimensional reconstruction of the coronary artery was then performed. 52 patients were selected as the research objects, and standardized rehabilitation nursing was carried out after surgery to analyze the vascular lesion rate of arterial bridge and venous bridge and compare their nursing satisfaction. The results showed that the CTA images were clearer after reconstruction. The number of male patients with venous and arterial lesions was significantly higher than that of the female patients, and the difference between the two groups was obvious

P
<
0.05

. The number of patients combining with risk factors and LIMA bridge vessels was 0 in grade 3 patients, accounted for the highest proportion (16.67%) in the grade 1 patients, and was 2 in the grade 2 patients (accounting for 4.17%). The satisfaction of patients who received standardized nursing was 97.25%, that of patients who received conventional nursing was 83.42%, and the difference was significant

P
<
0.05

. In conclusion, CTA images of patients’ cardiac vessels can be clearly seen by using a block image reconstruction algorithm, which can realize clinical personalized treatment. In addition, patients were more satisfied with standardized rehabilitation nursing.
MAIP1-Related Tumor Immune Infiltration: As a Potential Prognostic Biomarker for Esophageal Cancer
Authors: He Xiaoyu , Gan Fu , Lin Yongjian , Liu Guoqing , Lin Yunhua , Chen Dongxu
Published: June 2022

Background. Esophageal cancer (EC), a common malignant tumor of digestive tract, is also one of the most deadly cancers. Accumulating studies have shown that the initiating and progressing multiple human diseases were closely related to the expression of MAIP. However, the specific roles and mechanisms of MAIP1 in EC remain incompletely defined. Purpose. This study aims to determine the clinical significance of MAIP1 in EC and explores its potential molecular mechanisms regulating tumor immune infiltration. Methods. We obtained RNA-seq datasets and corresponding clinical data for EC patients from the Cancer Genome Atlas (TCGA) database via the UCSC Xena browser to extract MAIP1 expression and plot survival curves to determine their prognosis. Based on the differential expression of MAIP1, EC patients were divided into high and low group to investigate the mechanism of MAIP1 in EC. In addition, the single sample gene set enrichment analysis (ssGSEA) quantified the expression of various immune cell signature marker genes and assessed the degree of immune infiltration in EC. Results. In the TCGA-EC cohort, the overexpression of MAIP1 was observed in tumor tissues compared to normal tissues (

p
=
0.0038

). Overall survival analysis showed that EC patients with the overexpression of MAIP1 presented a lower overall survival and worse prognosis (

p
=
0.004

). Enrichment analysis revealed that the differential genes (DEGs) between high and low group are involved in biological functions such as extracellular matrix and organization extracellular structure. The results of ssGSEA showed that DCs, iDCs, macrophages, mast cells, and NK cells were significantly different in MAIP1high and MAIP1low groups, and all showed high expression in the MAIP1low group. Conclusion. We proposed that MAIP1 overexpression was associated with poor prognosis and tumor immune infiltration in EC. At present, there are few MAIP1-related tumor immune infiltration studies in EC, and further investigation is needed.
Scene Classification in the Environmental Art Design by Using the Lightweight Deep Learning Model under the Background of Big Data
Authors: Liu Lu
Published: June 2022

On the basis of scene visual understanding technology, the research aims to further improve the classification efficiency and classification accuracy of art design scenes. The lightweight deep learning (DL) model based on big data is used as the main method to achieve real-time detection and recognition of multiple targets and classification of the multilabel scene. This research introduces the related foundations of the DL network and the lightweight object detection involved. The data for a multilabel scene classifier are constructed and the design of the convolutional neural network (CNN) model is described. On public datasets, the effectiveness of the lightweight object detection algorithm is verified to ensure its feasibility in the classification of actual scenes. The simulation results indicate that compared with the YOLOv3-Tiny model, the improved IRDA-YOLOv3 model reduces the number of parameters by 56.2%, the amount of computation by 46.3%, and the forward computation time of the network by 0.2 ms. It means that the IRDA-YOLOv3 network obtained after the improvement can realize the lightweight of the network. In the scene classification of complex traffic roads, the classification model of the multilabel scene can predict all kinds of semantic information of a single image and the classification accuracy for the four scenes is more than 90%. In summary, the discussed classification method based on the lightweight DL model is suitable for complex practical scenes. The constructed lightweight network improves the representational ability of the network and has certain research value for scene classification problems.