bluuebunny/crossref_metadata_2025 huggingface dataset:
Turmeric Gel as alternative Non-Vital Pulpotomy medicament in Primary teeth- A Randomized Controlled Trial
Authors: Mazhar Mashal , Naz Shazia , Zahra Ambreen , Bashir Nazia , Dastgeer Rabia
Published: April 2024

Background and objective: Formocresol is a gold standard medicament in both vital and non-vital Pulpotomies due to its potent antibacterial potential but, it has a controversial nature due to its side effects. Therefore, the demand for natural alternatives of Formocresol as a pulp dressing material, with few or no side effects, became imperative. The purpose of the study was to introduce Turmeric gel as non-vital Pulpotomy medicament in primary teeth by evaluating its antibacterial effect against Streptococcus mutans and Lactobacillus acidophilus.

Method: It was a multi-arm parallel Randomized Controlled Trial in which sixty patients aged between 4 to 8 years, each containing at-least one non-vital primary molar, were selected and randomly divided into Group A (Formocresol) and Group B (Turmeric gel). Non-vital Pulpotomy was performed by removing the coronal necrotic pulp. Sterile paper points were dipped in the root canals and taken to the laboratory. Cotton pellets soaked in the respective medicaments were placed over the root canal orifices and filled temporarily. Patients were recalled after one week. Samples were again taken, and tooth restored. Comparison between bacterial count at baseline and after one week of treatment was made and expressed as Colony-Forming Units/ml (CFU/ml).

Results: There was a significant reduction in median Streptococcus mutans and Lactobacillus acidophilus bacterial count in each group after one week of treatment (p < 0.001). Formocresol showed higher average reduction than Turmeric gel. However, statistically, the difference was insignificant indicating that both the medicaments possessed comparable antibacterial effect.

Conclusion: Turmeric gel was found as effective alternative to Formocresol.

Randomized Controlled Trial registration number in ClinicalTrials.gov: NCT05801354

 
A Youth-Led Congress on Children's Mental Health: Voices, Experiences, and Policy Implications
Authors:   Prenatal Sciences Research Institute SOPHIA, Greece, Gouni Olga , Morano Sandra ,   2.	Department of Neurology, Ophthalmology, Genetics, Mother and Infant Sciences, Medicine School, University of Genoa, Genoa, Italy, Calleja Amelie ,   Malta Foundation for the Wellbeing of Society, Malta, Calleja-Agius Jean ,   4.	Department of Anatomy, Faculty of Medicine and Surgery, University of Malta
Published: April 2024

This report synthesizes the proceedings of a youth-led congress focused on the profound impacts of the COVID-19 pandemic on children's mental health. The congress provided a platform for children to articulate their experiences, express concerns, and propose recommendations. The findings underscore the need for policymakers to heed the voices of children in shaping mental health policies and support systems.
Autism in the Context of Humanitarian Emergency: The Lived Experiences of Syrian Refugee Mothers of Children on the Autism Spectrum
Authors: Bernier Abdullah , McCrimmon Adam , Nsair Sumaya , Hans Henna
Published: April 2024

This study explored the resettlement experiences of Syrian refugees accessing supports and services for their autistic children in Alberta, Canada. Using interpretive phenomenological analysis (IPA), in-depth interviews with three participants led to seven shared themes regarding parental experiences with the Syrian crisis, access to supports and services, barriers to resettlement, and sentiments regarding their resettlement. Findings are explained using migrant adaptation models to situate practice within a social justice orientation by understanding the perspectives of vulnerable migrant populations. Practical implications include ways to benefit refugees, imbue culture within practice, inform policy initiatives, and highlight the importance of trauma-informed care.
Tisagenlecleucel for Treatment of Refractory or Relapsed B-cell Acute Lymphoblastic Leukemia (R/R B-All): A Systematic Review of Cost-Effectiveness Analysis
Authors: Thao Nguyen Phung , Van Thuy Ha , Thi Xuan Bui
Published: April 2024

Tisagenlecleucel is a new immunological therapy in refractory or relapsed B-cell lymphoblastic leukemia with high expense. Objective: To assess the quality as well as analyze characteristics and results of cost-effectiveness analysis (CEA) of tisagenlecleucel immunological therapy in children with R/R B-ALL. Method: To analyze systematic review of articles published during the period of 2017-2023 in Pubmed, ScienceDirect, GoogleScholar, Cochrane databases. Result: 10 selected studies were carried out in 8 nations with different cost units and discount rates. Compared therapies were standard therapy of each country included Blinatumomab, Clo-C, Clo-M, FLA-IDA, FLAG-IDA. Of 10 studies, 70% was considered cost-effectiveness, 20% non-conclusion and only 10% not cost-effectiveness. Conclusion: Tisagenlecleucel’s cost is the highest among compared therapies but it can be cost-effective in a nation with WTP threshold of $100.000-$150.000.

Keywords: Systematic review, cost-effective, tisagenlecleucel, CAR-T, acute lymphoblastic leukemia.
PENDIDIKAN ĀTMAVIDYĀ SEBAGAI METODE PENGENDALIAN DIRI DALAM MENGHADAPI REVOLUSI INDUSTRI 4.0
Authors: Dwik I Made Dwi Susila Adnyana
Published: April 2024

Revolusi industri 4.0 merupakan model transformasi industri revolusioner yang berbasis pada koneksitas sistem siber dalam implementasinya. Perubahan peradaban dunia yang sangat cepat di berbagai negara, ditandai dengan penggunaan sistem informasi tanpa batas berbasis komputasi dan big data. Dampak positif yang bisa dirasakan ialah kemudahan dalam mengakses informasi dengan menggunakan gadget, mudahnya pembelajaran dengan menggunakan e-learning, dan lain sebagainya. Namun disisi lain, revolusi industri 4.0 juga memberikan dampak negatif seperti lebih rentan terhadap serangan cyber dan mudah masuknya situs ilegal, sehingga sangat riskan terhadap degradasi moral manusia. Untuk dapat mengantisipasi dan meminimalisir perkara tersebut, dibutuhkan sebuah metode khusus yang bertujuan sebagai pengendalian diri. Apabila dalam diri manusia sudah dapat dikendalikan dan dikontrol sesuai dengan kaidah kebenaran (dharma), maka output yang dihasilkan juga akan sesuai dengan hakikat “manusia” yang sesungguhnya, yaitu ‘manut teken sesana’. Berkaitan dengan hal tersebut, maka akan timbul sebuah pertanyaan: metode apakah yang dapat digunakan untuk mengendalikan diri dalam menghadapi revolusi industri 4.0? Metode tersebut ialah melalui pendidikan Ātmavidyā.

Kata Kunci: Pendidikan Ātmavidyā, Metode Pengendalian Diri, Revolusi Industri 4.0
THE IMPLICATIONS OF THE HINDU RELIGIOUS EDUCATION AND ETHICS TEACHER'S STRATEGY FOR STRENGTHENING INDICATORS OF RELIGIOUS MODERATION AT SARASWATI 6 DENPASAR ELEMENTARY SCHOOL
Authors: Gede Darma Permana I Dewa
Published: April 2024

Ethnocentrism, exclusivity, and intolerance are challenges that a pluralistic country like Indonesia must face. Considering these problems, a strategy by teachers is needed to strengthen the existence of religious moderation in the school environment, such as what is done by Hindu Religious Education and Ethics teachers at Saraswati 6 Denpasar Elementary School (SD Saraswati 6 Denpasar). Reflecting on this, this study is interested in presenting the implications of the Hindu Religious Education and Ethics teacher's strategy for strengthening indicators of religious moderation. The formulation of the problem in this study is answered systematically, starting from the implications of strengthening indicators of national commitment, tolerance, non-violence, and accommodation of local culture. The research method in this paper is a qualitative type of research with a descriptive naturalistic-based field research approach. The data sources used come from primary and secondary sources. Data collection methods that use observation techniques, interviews, literature studies, and data analysis that uses the approach of Miles and Huberman. The results of this study indicate that the strategies implemented by Hindu Religious Education and Ethics teachers are able to have a positive impact on strengthening indicators of religious moderation at SD Saraswati 6 Denpasar, both in terms of indicators of national commitment, tolerance, non-violence, and accommodation of local culture. The results of this paper are intended as guidelines for teachers to anchor the concept of religious moderation in schools.
MEMBANGUN KARAKTER ANAK YANG BERTANGGUNGJAWAB MELALUI CERITA ARANYAKANDA
Authors: Ayu Putu Agung Mirah Febriyanti Gusti
Published: April 2024

The purpose of this article is to facilitate us to teach responsible attitude to children, by means of the stories that be found in the books Itihasa and Puraana. Today many children are found not enaugh even no sense of responsibility, not only on the assignment it has but sometimes even in it self they are have not responsibility. Lack of responsible sense can affect a child's morale.Moral shift can be regarded as one indicator of weak understanding of religious values. By means of Aranyakanda not only can make a sense of responsibility in children but indirectly we can also teach the religious values.In the teachings of Hinduism the form of human responsibility is described in the concept of Tri Hita Karana such as of Prahyangan, Palemahan and Pawongan.
Current Situation of Mental Health of Older Adults: A Case from Henan Province, China
Authors: Li Xin , De Ala Minerva B. , Wang Fengxia , Zhang Yi
Published: April 2024

Background: The population ageing process has changed the world’s population composition. China's population is ageing rapidly, and many researchers have focused on the psychological problems of older adults.

Objective: To investigate the current state of mental health of older adults in China, understand the current level of mental health of older adults in China and its influencing factors, provide a reference for the formulation of mental health intervention measures, and scientifically protect the mental health of older adults.

Methods: Convenience sampling was used to select 196 older people aged 60 and above in the Central Plains of China as the research objects. The questionnaire survey method was used to investigate the mental health status of older adults.

Results: Among the 196 older people, 145 had no psychological symptoms, accounting for 74.0%; 45 had mild psychological symptoms, accounting for 23.0%; 4 had moderate psychological symptoms, accounting for 2.0%; 2 had severe psychological symptoms, accounting for 1.0%. There were statistically significant differences in the mental health scores among older adults with different ages, marital statuses, number of chronic diseases, and economic income (P<0.05).

Conclusion: The mental health status of older adults in China is average. Age, marital status, number of chronic diseases, and income level impact the mental health of older adults. The whole society should pay attention to the mental health ofolder adults.
Analysis of Adverse Drug Reactions caused by antipsychotic drugs in a Mexican health institute
Authors:   Universidad Autónoma Metropolitana Xochimilco Unity, Rojas-Valladares Erick , Aguilar-Salas Ismael ,   Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Sánchez-Herrera Karina ,   Universidad Autónoma Metropolitana Xochimilco Unity, Heyerdahl-Viau Ivo ,   Universidad Autónoma Metropolitana Xochimilco Unity, Benitez-Morales Jonatan ,   Instituto Nacional de Enfermedades Respiratorias, Martínez-Núñez Juan M. ,   Universidad Autónoma Metropolitana Xochimilco Unity
Published: April 2024

Introduction: Adverse Drug Reactions (ADR) are unwanted clinical or laboratory manifestations that are related to drug use. ADR are common and are associated with significant risk of morbidity, mortality and hospital admissions. Antipsychotics have a reduced therapeutic window, and have been related to the manifestation of a variety of ADR. Objective: To evaluate the pattern of ADRs due to antipsychotic drugs detected in patients treated at the Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz between December 2021 and May 2022. Methods: Observational, descriptive, prospective and cross-sectional study of a series of cases. The seriousness, severity, and quality of the information in the notification of the ADR were defined in accordance with NOM-220-SSA1-2016, Installation and Operation of Pharmacovigilance, while causality was determined using the Naranjo algorithm. Results: The incidence of ADRs was 59%, with one or more ADR detected in 52 of the 88 patients who were receiving antipsychotic treatment during the study period. Forty-five percent of the ADR had probable causality and 55% possible; only three ADR were classified as serious as they prolonged the hospital stay and endangered the patient's life. Conclusions: The ADR of the gastrointestinal and endocrine systems were the most incidental, with hyperprolactinemia being the most frequent. Olanzapine and clozapine were the medications that caused the most ADR. It is recommended to promote the culture of notification and follow-up of ADR caused by antipsychotic drugs.
Sociodemographic factors associated with domestic violence in women in Peru, 2021
Authors:   Universidad Ricardo Palma, Perez Yari Luis F. , Loo Valverde María ,   Universidad Ricardo Palma, Chanduvi Puicon Willer D. ,   Universidad Ricardo Palma
Published: April 2024

Introduction: Domestic violence is based on phenomena that establish a relationship of subordination, whose behaviors are related to physical, psychological and sexual damage, through the actual or symbolic use of force, with the aim of dominating the will, mind and body of the victim. Objective: To determine the sociodemographic factors associated with women victims of domestic violence in Peru during the year 2021. Materials and Methods: This is an observational, retrospective, analytical and cross-sectional study, developed through the ENDES 2021 secondary databases, using information from 21,557 women. Said information was analyzed using the SPSS vers.27 statistical software and prevalence ratios were used through the Poisson regression model with robust variance. Results: A prevalence of 47.7% for psychological violence was determined. The multivariate analysis identified that the variables associated with psychological violence were the level of primary education (APR: 1.10) and the metropolitan Lima region (APR :1.14). Regarding sexual violence, the poor wealth level (APR: 2.35) was the associated variable, and for physical violence, the age of 20 to 29 years (APR: 1.21), poor wealth level (APR: 1.495) and the coastal region (APR: 0.79). Conclusions: Factors associated with psychological violence were identified as the level of education and the natural region, marital status was a protective factor against sexual violence, and the variables of age and wealth level were associated with physical violence.
Aplicação de produtos técnico e tecnológico em oficina de educação permanente sobre a problematização com Arco de Maguerez
Authors: Borges Renata Campos de Sousa , Vieira Gabriel Costa , Sousa Júnior José Ronaldo Teixeira de , Ferreira Ilma Pastana , Caldato Milena Coelho Fernandes , Bastos Mírian Letícia Carmo , Silva Laís Araújo Tavares , Costa Leandro de Assis Santos da , Botelho Nara Macedo , Silva Márcia Daniela Aragão
Published: April 2024

Objetivo: Aplicar produtos técnicos e tecnológicos em oficina de educação permanente sobre a problematização com o arco de Maguerez, como proposta para avaliação do nível de satisfação dos participantes. Métodos: Estudo metodológico fase de aplicação com abordagem quantitativa, descritivo e exploratório, aplicado aos participantes docentes e discentes da comunidade acadêmica na área da saúde. Resultados: Índices de satisfação com correlação positiva entre os domínios analisados: conteúdos e objetivos; implementação e potencialidade; e aplicabilidade de produtos, com índice de satisfação global positivo em 82%. Consistência e confiabilidade do instrumento de coleta analisada pelos Coeficiente de Correlação Interclasses (ICC) e alfa de Cronbach com índices globais excelentes. Fortes associações quanto ao alto índice de satisfação pela totalidade dos participantes com as variáveis conteúdo, inovação, interação e replicação. Conclusão: Os participantes demonstraram satisfação com a integração dos produtos aplicados oportunizando a sistematização de ações educação permanente nas práticas educativas no âmbito educacional de forma eficiente, favorecendo a interação e a promoção do conhecimento coletivo para a metodologia da problematização com o arco de Maguerez.
Consequências da COVID-19 em pacientes com obesidade
Authors: Nobre Aglaene de Almeida , Pereira Maysa Jacqueline Vale , Barroso Wermerson Assunção
Published: April 2024

Objetivo: Relacionar as consequências da COVID-19 com os achados das pesquisas realizadas em pacientes com obesidade que foram atingidos pela doença. Revisão bibliográfica: A literatura internacional sugere uma relação significativa entre a obesidade e a gravidade da COVID-19. A realização de investigações utilizando protocolos clínicos e epidemiológicos é crucial para estabelecer de forma mais precisa a conexão entre a obesidade e o risco de complicações da COVID-19. Essas pesquisas podem ajudar a obter uma compreensão mais aprofundada dessa associação e identificar os fatores subjacentes que contribuem para as complicações concomitantes em pacientes com sobrepeso. Considerações finais: A obesidade é uma doença crônica não transmissível, representando um fator de risco significativo para o agravamento da COVID-19. No entanto, é essencial ressaltar que ela é passível de prevenção. A adoção de hábitos saudáveis de vida não apenas pode mitigar os riscos associados à obesidade, mas também tem o potencial de reduzir a gravidade das infecções pela COVID-19, considerando que ambas são condições caracterizadas por processos inflamatórios.
Transition et transgression
Authors: Levasseur Hélène
Published: April 2024

Nous cherchons, par la mise en parallèle des notions de transition et transgression, à comprendre les processus de changement et leur utilisation dans le discours notamment écologique. Nous montrerons, au prisme de la sémiotique lotmanienne, l'importance du rapport à la frontière et la norme dans la compréhension des dynamiques de changement de ces notions, mais également de leurs degrés de prévisibilité et de leurs capacités d'innovation. Par le biais de la sémiotique tensive, nous aborderons les problématiques de rythme, d'intensité et d'extensité afin de nous permettre d'interroger la compatibilité tensive entre la transition écologique et la crise écologique. Une analyse sémantique révélera que le double sens de transgression - dépasser/enfreindre - permet de définir une transformation comme une innovation ou comme une infraction. La notion de transition devient-elle un outil de prédiction, de contrôle du changement et de maintien de la norme face à l'imprévisible ?
Transition médiatique sur les corps et pratiques homosexuels : de la censure à la présence obligatoire
Authors: Lima Sued , Oliveira Taís de
Published: April 2024

Au Brésil, pendant le XXe siècle, les corps et les pratiques homosexuels étaient constamment réprimés et censurés ; la prédominance d’une morale conservatrice a contribué à la promotion d’actions discriminatoires de la part de la société civile et de l’État. Aujourd’hui, l’émergence des discours qui promeuvent la reconnaissance des LGBTQIAP+ cherche à répondre aux demandes sociales et médiatiques. Les demandes sociales se réfèrent à l’inclusion de cette minorité qui se constitue comme une « identité concessive » (Oliveira 2021) par rapport à des constructions identitaires hétérocisnormatives. Les demandes médiatiques correspondent aux intérêts marchands qui s’adaptent aux exigences sociales et donnent lieu à l’insertion de personnages LGBTQIAP+ dans diverses sphères de communication. Afin d’aborder ces transitions socioculturelles et médiatiques, nous mobilisons des concepts de la sémiotique pour comparer la répression des homosexuels qui a été mise en évidence dans les articles d’opinion du journal Lampião da Esquina (1978-1981) avec la présence de nombreux corps LGBTQIAP+ dans les productions médiatiques contemporaines.
La transition au sein de l’être humain : France (2021) de Bruno Dumont
Authors: Bonéva Ralitza
Published: April 2024

L'hypermodernité, annoncée depuis les dernières décennies du XXe siècle, ne manquera pas de produire des modifications au sein de l'être humain. Engendreront-elles une transition ou une mutation dans l’humain et en quoi consistera-t-elle ? Notre étude, qui s’inscrit dans la perspective d'une sémiotique de l'existence, tente de répondre à ces questions, problématisant le concept de forme d'existence en tant que régime de signification, différent de ceux de forme de vie et de style de vie. La forme d’existence se conçoit sur les effets de sens produits par les rapports que l’individu entretient vis-à-vis de soi-même, de son vécu, d’autrui, dans et envers le vivre-ensemble et quant à la sémiosphère à laquelle il adhère ou non.
La transition et l’utopie : de l’utopie grâce à la transition à la transition grâce à l’utopie
Authors: Colas-Blaise Marion
Published: April 2024

Cet article se propose, d’une part, de dégager un soubassement transitionnel de la transformation, qui gère le flux du sens et les métamorphoses, et, d’autre part, de montrer que la transition garantit la fluidité de la textualisation elle-même. La transition ainsi conçue peut alors faciliter la production d’utopies, en particulier d’écotopies, en-deçà ou au-delà de l’opposition entre deux états de la société et deux rationalités jugés incompatibles. Enfin, il s’agit d’approcher la transition à la lumière d’un « tiers lieu », qui partage certaines propriétés avec la « zone utopique » (Fontanille 2021) et s’ouvre aux relations interpersonnelles placées sous le signe ducare, mais aussi à l’imaginaire (« réenchantement »), à la création et à l’invention.
Les mutations sociétales à l’égard de la véridiction et de la fiducie
Authors: Luz Pessoa de Barros Diana
Published: April 2024

Cet article traite des transitions sociales résultant des changements dans les contrats véridictoires et fiduciaires proposés par Algirdas Julien Greimas. L’énonciateur du discours choisit un régime de véridiction afin de développer un faire croire chez son énonciataire, qui, à son tour, interprète le message et y croit ou non. Notre propos est de montrer que ces contrats font l’objet d’opérations et établissent différents parcours véridictoires. Les opérations d’assertion, de négation et d’implication déterminent quatre parcours parmi les métatermes de la véridiction : 1- fausseté → mensonge → vérité ; 2- vérité → secret → fausseté ; 3- fausseté → secret → vérité ; 4- vérité → mensonge → fausseté. Ces parcours caractérisent plusieurs contrats véridictoires : des fake news ; des fausses révisions de l’histoire ; des discours humoristiques et poétiques ; des discours poétiques « fondateurs ». Au Brésil, les deux premiers parcours, dans lesquels l’apparence sélectionne l’essence, sont des stratégies amplement utilisées par l’extrême droite ; les deux derniers, dans lesquels l’essence sélectionne l’apparence, sont caractéristiques de la gauche.
Penser la maintenance : outil conceptuel ou pratique et poétique de la coexistence ?
Authors: Bondì Antonino
Published: April 2024

Le terme « maintenance » fait l’objet de nombreuses discussions dans des domaines disciplinaires hétérogènes et dans des champs d’expérience fort divers, comme par exemple le discours politique, les études environnementales, la philosophie morale, les sciences de l’aménagement urbain et de la construction etc. En effet, des termes tels maintenance, care, réparation, se retrouvent de plus en plus au cœur des nombreux dispositifs conceptuels qui s’interrogent sur les problèmes concernant la coexistence, la survie et l’entretien des artefacts sociaux, des êtres vivants (humains et non-humains), ainsi que des environnements physiques et des habitats (ou milieux naturels). Il semblerait que la question de la « maintenance » ait le statut d’un véritable thème pivot dont toute pensée ou culture écologiste ne pourrait pas faire l’économie, car elle croise plusieurs questions qui intéressent la sémiotique : i) la complexité des relations entre les différentes ontologies sociales qui organisent et structurent la vie des objets et des êtres ; ii) le prolongement du temps de vie de ces objets (et êtres) tout au long d’échelles temporelles variables (ou du moins très différentes), et surtout dans des conditions de vie adéquates ; iii) les rapports de signification entre ces régimes de coexistence. C’est en vertu de ces raisons que la sémiotique — discipline travaillant sur les cultures en tant que milieux hétérogènes — ne peut point ignorer ce thème de recherche.
Transition écologique, transition littéraire : la représentation de la communication du vivant dans les Sciences et les Lettres
Authors: Mérigonde Mireille
Published: April 2024

Les sciences et la philosophie proposent une vision renouvelée des mondes animaux et végétaux. La littérature prend acte des avancées en la matière et participe à la sensibilisation et à la conscience écologiques en recherchant une position non anthropocentrée dans sa représentation du vivant. Cet article fait le point sur la question très spécifique de la représentation de la communication animale et végétale qui, pour les écrivains, constitue un véritable défi. Nous montrerons dans un premier temps qu’un changement de paradigme s’est opéré dans les sciences du langage sur la question du langage animal. Nous verrons ensuite que la communication végétale devient également un objet d’étude saillant dans les sciences. Nous pourrons alors envisager comment, par le biais de la médiation littéraire, ces nouvelles « voix » peuvent nous guider sur la « voie » de la transition écologique.
La transition écologique dans le vin, une question sémiotique : l’exemple de la taille de la vigne
Authors: Beslay Pierre
Published: April 2024

Les sciences de l’information et de la communication (SIC) s’appuient largement sur la sémiotique, notamment pour analyser les divers aspects de la transition numérique. Nous aimerions ici montrer, à la suite d’Andréa Catellani (2022), que la sémiotique peut également nous aider à penser la transition écologique. Pour cela, nous nous appuyons sur le cas des pratiques des vignerons et en particulier la taille de la vigne que nous avons étudiée dans le cadre d’un travail ethnographique. La taille durable de la vigne peut en effet être étudiée comme une activité au cours de laquelle le tailleur adresse et reçoit des signes du pied de vigne.
Existe-t-il des œuvres transitoires ? Le désœuvrement de l’art à partir de Robert Filliou : un défi sémioesthétique
Authors: De Luca Valeria
Published: April 2024

Existe-t-il des œuvres transitoires ? Cette question est posée au premier chef comme un défi, car pour y répondre faut-il d’abord définir le transitoire ou, mieux, la manière dont la transition peut s’appliquer à des manifestations de l’art telles des « œuvres ». Dans cette contribution, nous chercherons à appréhender la transition d’un point de vue initialement méthodologique afin de mettre en lumière son potentiel heuristique vis-à-vis d’objets sémiotiquement denses. L’hypothèse est la suivante : la transition permet de réactiver l’interrogation sur le statut objectal des productions artistiques qui ne sont pas des « œuvres » au sens traditionnel du terme. L’examen du Principe d’équivalence de Robert Filliou exemplifiera le changement de regard épistémologique nécessaire afin de relever le défi sémioesthétique posé par ces objets sémiotiques et nous permettra de revenir sur certaines dynamiques générales de la sémiose, dont notamment une réévaluation des oppositions participatives de Louis Hjelmslev.
Sans transition. Enquête sur la place des transitions dans l’espace des pratiques numériques
Authors: Bertin Éric
Published: April 2024

C’est le chemin et ses indéterminations, ses renversements, et non le dessein, qui semble caractériser la transition numérique. Plus encore, la conception sémiotique de la transition l’envisage comme un parcours non téléologique, caractérisé comme un « espace-temps critique » (Basso, 2017). Pourtant, la praxis numérique est marquée, dans certaines pratiques, par des opérations d’éviction ou de virtualisation des transitions spatialisantes et temporalisantes. Cet article vise à s’interroger sur les modalités et le rôle de cette virtualisation de la transition dans l’espace numérique, en s’appuyant notamment sur la séquence requête/résultat des moteurs de recherche. Nous tenterons de mettre en lumière les significations socioculturelles en négociation dans cette tension entre pratiques individuelles et ontologie du numérique.
Lire, écrire, co-écrire, partager, référencer les écrits. Transitions linguistiques au sein de la culture numérique
Authors: De Angelis Rossana
Published: April 2024

La culture numérique est une culture écrite. La production de textes numériques repose sur l'utilisation d'un système d'écriture qui possède ses propres signes et ses propres règles, le code de programmation, ainsi que sur des dispositifs de communication prédisposant cette pratique. Plus particulièrement, si l'on s'intéresse aux écrits linguistiques, on peut identifier différentes phases de développement (web 1.0, web 2.0, web 3.0) qui dépendent des avancées technologiques des dispositifs de production et de réception ainsi que des dynamiques de circulation des écrits (lecture, production, coproduction, partage et référencement d’écrits linguistiques numériques). Dans cet article nous proposerons une brève histoire de la textualité linguistique numérique, ainsi qu’une réflexion critique sur les enjeux sémiotiques des transitions entre les différentes étapes de cette histoire.
La transition écologique : valeurs aspectuelles
Authors: Badir Sémir
Published: April 2024

Le sens de la formule « transition écologique » est peu compréhensible à partir des usages ordinaires du mot transition. Contrairement à ce que prétend la version française de Wikipédia à l’entrée « Transition écologique », il ne provient pas non plus d’un « concept élaboré par Rob Hoskins », pas même pour « l’édition en français » du Transition Handbook. Ce sens doit beaucoup en revanche à l’acception gender du mot transition en langue anglaise. Il a à voir aussi avec le concept de environmental risk transition avancé par des épidémiologistes dans les années 1990. Enfin, plus profondément, il entre en résonance avec la conception marxiste de la transition capitaliste. Cette étude repère, en fonction d’une analyse sémantique des acceptions ordinaires et savantes évoquées ci-dessus, les valeurs aspectuelles qui rendent plausible le passage de la locution Transition Town (Hoskins 2008) à la formule « transition écologique ».
التركيب الفلوري، أشكال الحياة والارتباط الجغرافي لنباتات المنطقة الممتدة من عقان إلى العرائس، محافظة لحج، اليمن
Authors: عاطف مازن علوي علي سالم , السوبر أحمد محمد مقبل , الحوشبي عثمان سعد سعيد
Published: April 2024

تناولت الدراسة الحالية فلورا أجزاء من مديريتي المسيمير وتبن وذلك للمنطقة الممتدة من عقان حتى العرائس، خلال الفترة من مارس 2020 حتى ديسمبر 2022، وأسفرت الدراسة عن تسجيل 208 وحدة تصنيفية (شملت الأنواع ووحدات تحت النوع والضروب) تنتمي لـ 132 جنسًا تقع ضمن 48 عائلة نباتية، ضمنهم 5 عائلات نباتية تنتمي لذوات الفلقة الواحدة و 43 عائلة نباتية تنتمي لذوات الفلقتين، وأثبتت النتائج أن أكثر الفصائل النباتية تنوعًا وتمثيلًا هي العائلة البقولية Fabaceae (26 نوع)، تليها العائلة النجيلية Poaceae والعائلة اللبينية Euphorbiaceae (13 نوع لكل منهما)، ثم العائلة القطيفية Amaranthaceae (عرف الديك) والعائلة الدفلية Apocynaceae والعائلة الباذنجانية Solanaceae (12 نوع لكل منها). أتضح أن أكثر الأجناس تنوعًا في ضمن فلورا منطقة الدراسة هي الأكاشيا Acacia والهليوتروبيوم Heliotropium تضمنا 7 أنواع لكل منهما. أثبتت نتائج تحليل الشكل المظهري (شكل الحياة) للأنواع المسجلة أن النباتات فوق سطحية كانت السائدة حيث تمثلت بـ (79) نوع نباتي بنسبة (37.98%)، تليها النباتات الحولية والتي تمثلت بـ (60) نوع نباتي بنسبة (28.85%)، والنباتات الظاهرة والتي تمثلت بـ (41) نوع بنسبة (19.71%). أضيف إلى الفلورا اليمنية النوع Datura ferox لأول مرة من منطقة الدراسة. الأنواع النباتية المائية والمحبة لرطوبة التربة العالية تمثلت بـ 9 أنواع نباتية تنتمي لـ 8 عائلات نباتية. اسفرت النتائج عن تسجيل 5 أنواع نباتية متوطنة في اليمن و11 نوع نباتي متوطنة في اليمن والسعودية وعمان. تبين من خلال تحليل التوزيع الجغرافي للأنواع النباتية المسجلة في منطقة الدراسة وارتباطها الجغرافي العالمي أن معظم أنواع المنطقة تنتمي للإقليم السوداني – الزامبيزي.
Particularităţi clinice şi terapeutice în dermatofibrosarcomul protuberans – studiu de caz
Authors: Anda-Elena Crişan , Oana Rusu , Simona-Maria Hristea , Robert-Valeriu Timofticiuc , Radu-Mihai Ştefan , Bălan Marian-Răzvan
Published: April 2024

Dermatofibrosarcoma protuberans (DFSP) is a rare form of skin cancer characterized by local aggressiveness, typically affecting individuals in the young to middle-aged adult range. The authors of this article aimed to present the clinical picture, as well as the therapeutic approach to a patient undergoing oncological surveillance with DFSP, analyzing the therapeutic response rate based on data published in specialized journals. A 72-year-old man was admitted to the radiation oncology department, having
a 75/58 mm tumoral mass on the right posterior cervical region. The patient underwent two radical tumor excision surgeries and interval skin grafting, leading to a negative prognosis for the patient, as the tumor reappeared aggressively in a short period, four months, more exactly. The study highlighted the importance of surgical intervention, such as wide local excision, in preventing recurrence and the major role of initiating timely adjuvant treatment, including radiotherapy. The previously performed studies
suggest that radiotherapy can be beneficial following resection with negative margins, and it can serve as primary therapy for patients with inoperable or incompletely excised DFSP. In this case, the only therapeutic response was stopping the progression of the tumor growth and macroscopic changes of the tumor surface with areas of necrosis. This study also discusses the use of imatinib as the only left therapeutic option, due to the lack of radiotherapy response.
ANALYSIS OF SLOPE STABILITY DUE TO ILLEGAL GOLD MINING IN BENGKAYANG REGENCY
Authors: Saputra Andrianus , Priadi Eka , Rustamaji Rustamaji
Published: April 2024

Illegal gold mining is extracting gold without a formal license from the government or competent authority. It presents a significant environmental and geological challenge in Bengkayang Regency, Indonesia. This practice, carried out without proper authorization or adherence to safety regulations, is recognized as a significant cause of slope instability in the area.This study analyzes slope stability from unlicensed gold mining in Kinande Village, Bengkayang Regency. It uses manual Fellenius calculations and Geo Studio/Geo Slope 2023 software to determine the Safety Factor (SF) for potential landslides, assuming circular landslide planes are unaffected by earthquakes.Laboratory tests revealed varying soil types and properties at these points, impacting shear strength and slope stability. Loamy soils exhibit high cohesion but low internal friction, making them susceptible to instability. Sandy soils lack cohesion and rely on particle friction. Shear strength parameters like cohesion (c) and internal friction angle (φ) are critical in assessing slope stability. The study employed the Fellenius method and Geo Studio 2023 software to analyze slope stability, with safety factor (SF) results indicating potential hazards. Mining in plain areas showed favorable SF values (>1.5), suggesting activity safety. Conversely, mining in mountainous and watercourse areas exhibited lower SF values (<1.5), indicating instability and safety risks. Recommendations include stratified mining practices to maintain stable slopes and ensure miner safety. This research contributes to understanding geohazards and proposes measures for enhanced safety, environmental sustainability, and regulatory governance in mining areas. Understanding and analyzing these factors are crucial for the stability and safety of geotechnical projects, ensuring balanced shear stress and shear strength for slope stability.
Procedural Pain and Serious Adverse Events Following Bone Marrow Aspiration and Biopsy: Analysis from an Academic Center in India
Authors:   Department of Clinical Hematology, Christian Medical College & Hospital, India, CC Philip , A Mathew ,   Department of Clinical Hematology, Christian Medical College & Hospital, India, I Singh ,   Department of Clinical Hematology, Christian Medical College & Hospital, India, S Singh ,   Department of Clinical Hematology, Christian Medical College & Hospital, India, S Singh ,   Department of Clinical Hematology, Christian Medical College & Hospital, India, R Thapar ,   Department of Clinical Hematology, Christian Medical College & Hospital, India, MJ John ,   Department of Clinical Hematology, Christian Medical College & Hospital, India
Published: April 2024

Background: The Bone Marrow Aspiration and Biopsy (BMAB) is an important and frequent investigative procedure for hematological diseases. Although thought to be safe and well tolerated; data is limited on the complications and degree of pain experienced by patients undergoing BMAB. Further scarce is data from India and other regions from the developing world especially given the evidence that cultural factors that could shape pain perception. Adverse events following bone marrow biopsy are rare but poorly documented. Aims: To estimate the level of pain and frequency of serious adverse events experienced by patients undergoing BMAB at our center. We also attempted to identify factors associated with increased pain perception. Study Setting: This study was conducted at a tertiary level teaching hospital, the Christian Medical College & Hospital, Ludhiana. Ethics approval was obtained from the Institutional research committee (CMC/1495). Study Period: 01 April 2015 through 30 Nov 2019 Study Design: This is a comparative cross sectional study where comparison of those with relatively more pain to those with less was done to elicit the factors associated with pain perception. Results: A total of 942 BMAB procedures were performed in this period (Table 1). The major serious adverse event was hemorrhage, which comprised 2 of the 9 serious adverse events. Those with prior BMAB had very low odds of pain (OR (95% CI): 0.23 (0.15–0.37)). However, when more than one attempt of biopsy was made the odds of pain was much higher (OR (95% CI): 1.62 (1.29–2.05)).
Cytokine Patterns Associated with Bronchial Asthma in Saudi Patients
Authors:   Regional Laboratory, Ministry of Health, Madinah, Saudi Arabia, Omar Al-Saadi , Ziab Alahmadey ,   Public Health Laboratory, Ministry of Health, Madinah, Saudi Arabia, Omar Alblihshi ,   Regional Laboratory, Ministry of Health, Madinah, Saudi Arabia
Published: April 2024

Asthma is a common respiratory disease worldwide; most patients exhibit mild to moderate states of clinical severity. The aim of this study was designed to measure different cytokines (IL-4 and IL-5) levels in Saudi asthmatic patients and healthy volunteers’ serum, in addition to evaluating of the role of cytokines in clinical severity and diagnosis of bronchial asthma in Saudi patients. Through this study, 70 cases of Saudi bronchial asthma patients at different ages and case severity will be included in addition to 20 apparently healthy cases as a control. Serum cytokines (IL-4 and IL-5) levels will be measured by cytokines assay using Enzyme immunoassay. The results proved that the total levels of IL-4 and IL-5 were significantly higher in asthmatic patients than in control volunteers. Moreover, the concentrations of IL-4 in severe were significantly higher than those detected in moderate cases at different age groups for IL-4 but not in all age groups for IL-4. The Mean±SD for IL-4 in moderate was 13.55±1.25 pg/ml whereas in severe was 15.49±1.73 pg/ml while the Mean±SD of control was 7.55±1.47 pg/ml. The concentrations of IL-5 were non-significant in severe when compared with moderate cases. The Mean±SD for total IL-5 in moderate was 4.24±1.38 pg/ml whereas in severe was 4.46±1.40 pg/ml although the total Mean±SD in control was 2.29±0.37 pg/ml. Our results prove that there was a non-significant role of gender in bronchial asthma severity and there were no significant differences between serum cytokines levels in males and females in bronchial asthma. These results also expressed a significant role of IL-4 in the disease severity of asthmatic patients. Furthermore, detecting serum levels of IL-4 and IL-5 indicates the role of these cytokines in the development and pathogenesis of bronchial asthma.
Magnetic Therapies of Pancreas Diseases
Authors:   Retired, SchönblickstraΒe 95, 71272 Renningen, Germany, Former Member of the Max Planck Institute for Intelligent Systems, Stuttgart, Germany, M Fahnle
Published: April 2024

In my paper I describe magnetic therapies of pancreas diseases, and I explain the physical processes underlying these therapies.
Validity of Kramer Scale in Neonatal Hyperbilirubinemia
Authors:   Department of Pediatrics, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, Shaikh Sobia , Das Chetan ,   Department of Pediatrics, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, Kumar Jai ,   Department of Pediatrics, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, Chand Saroop ,   Department of Pediatrics, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, Hotwani Sonika ,   Department of Pediatrics, Liaquat University of Medical and Health Sciences, Jamshoro, Sindh, Pakistan, Jai Radhika ,   Charles University , 1st faculty of Medicine Prague Czech Republic  ²Sheikh Khalifa Medical City, PO BOX 51900, Abu Dhabi, UAE
Published: April 2024

Introduction: Jaundice refers to the yellow discoloration of sclera, skin and mucous membranes. It is a common problem that is faced during the first week of life by nearly every neonate. It is important to determine whether the clinical examination can be used reliably as a clinical screening tool for the diagnosis of neonatal jaundice. The diagnostic accuracy of Kramer’s rule was compared to venous method in this study in order to provide less invasive, time consuming and less painful method of measuring neonatal hyperbilirubinemia. Objective: To determine the diagnostic accuracy of Kramer’s rule of assessing neonatal hyperbilirubinemia taking serum bilirubin as “Gold standard”. Setting: New-born nursery at Paediatric Unit, Liaquat University Hospital, Hyderabad, Sindh. Design: Cross sectional validation study. Subject and Methods: A total of 317 neonates coming under inclusion criteria presenting at new-born nursery were examined. First, baby is undressed and clinical assessment of jaundice done. Then the venous blood sample was collected for serum bilirubin level and sent to diagnostic lab. Data was collected on predetermined pro-forma. Results: The average age of the neonate was 3.51±1.55 days. Sensitivity, specificity, positive predicted value, negative predicted value and accuracy of Kramer’s Rule in detection of neonatal hyperbilirubinemia was 90.7%, 80.5%, 88%, 84.6% and 86.75% respectively. Conclusion: Our study demonstrated that the Kramer’s scale could be better choice for detection and screening of neonatal hyperbilirubinemia. It is a non-invasive and quick method that can avoid babies from getting a skin infection or other complications related to blood sampling.
Correlation of Diabetes, Salivary Gland Cancer and Pancreatic Cancer with Iodine and Cesium Radionuclides
Authors:   Department of Hygiene, 61016-Rimini, Italy, Venturi Sebastiano
Published: April 2024

Oral and salivary health in the medicine of past centuries was considered a mirror of the health of the whole organism and a tool of great consideration in semeiotics and diagnostics, in particular, of the digestive system diseases. Recent studies confirmed that oral health is of fundamental importance for many systemic pathologies. Oral diseases, which are highly prevalent worldwide, are present in many human diseases: cardiovascular, infections, diabetes complications, pancreatic cancer, etc. [1]. This review reports the role of iodine and cesium, two important elements in the human organism. The author reports previous studies of the antioxidant role of iodine, and of carcinogen action of radio-iodine and radio- cesium in correlation with Pancreatic (PC), Thyroid (TC) and Salivary Gland Cancers (SGC) and with radioactive fallout [2-4]. Acinar cells of salivary glands and the exocrine pancreas have similar histological and biochemical feature, secreting same amylase enzymes, cesium, iodides. The worldwide death rate of PC, diabetes, Salivary Gland Cancer (SGC) and TC are increasing, but the exact cause is still not known. In particular, it has been shown that radio-iodine released from Chernobyl caused an increase in the incidence of TC, diabetes and oral diseases in the former Soviet Union and in Fukushima, but TC mortality rates are generally low. PC mortality is also increased in the U.S.A. [5,6]. SGC and PC death rate increase more than that of other cancers because, unlike many other cancers, PC is still hardly curable. The worldwide environmental radio-cesium is strongly suspected and investigated for these increases of PC, pancreatitis with secondary diabetes (type 3c) by damage of the beta cells of pancreatic islets and also of salivary gland cancer and oral diseases [7-11].
Comparative Analysis of Hepatocellular Carcinoma Patients with and Without Type 2 Diabetes Mellitus
Authors:   Clovis Community Hospital, Clovis, CA, Shergill Annie
Published: April 2024

Purpose of the Study: To evaluate the clinical impact of Type 2 Diabetes Mellitus (T2DM) in patients with Hepatocellular Carcinoma (HCC) in comparison to those without T2DM. Methods: Retrospective study, HCC data obtained from public domain (kaggle.com). Summary of Results Obtained: Mean age in the diabetic and non-diabetic groups were 70.4 and 62.08 years respectively. There was a female preponderance seen in both groups. Mean aspartate aminotransferase and alanine aminotransferase (AST/ALT) values in diabetic group were 81.42/54.8 U/L and in non-diabetic group were 116.72/77.4 U/L (p=0.19). Mean International Normalized Ratio (INR) in diabetic and non-diabetic groups were 1.51 and 1.34 respectively (p=0.32). Mean total bilirubin values in diabetic and non-diabetic groups were 2.39 and 1.95 mg/dL respectively (p=0.63). Total number of patients with varices were 33 in the diabetic and 32 in the non-diabetic group (p=0.59). Total number of patients with portal hypertension were 33 in the diabetic and 34 in the non-diabetic group (p=0.32). Portal venous thrombosis was found in 9 patients in the diabetic and 12 patients in the non-diabetic group (p=0.67). Metastatic disease was seen in 10 patients in the diabetic and 12 patients in the non-diabetic group (p=0.74).