bluuebunny/crossref_metadata_2025 huggingface dataset:
A TRANSPARÊNCIA NOS MUNICÍPIOS EM TRANSFORMAÇÃO: UM PANORAMA DO CUMPRIMENTO DA LEI DE ACESSO À INFORMAÇÃO
Authors: Montesso Júnior José Agnaldo , Leila Oliveira Campos Carla
Published: February 2025

A Lei nº 12.527/2011 está em vigor desde maio de 2012. Conhecida como Lei de Acessoà Informação (LAI), representa um importante arcabouço jurídico na busca de maistransparência, tanto na utilização de recursos públicos quanto no acesso à informaçãopela sociedade. Este trabalho analisa a transparência ativa e passiva descritas na referidalegislação. Para isso, utiliza a metodologia empregada pela Controladoria-Geral daUnião, na 2ª edição da Escala Brasil Transparente (EBT), e traz questionamentos enviadospor meio do Sistema Eletrônico de Informações ao Cidadão (e-SIC), previsto pela LAI. São analisados 20 municípios, sendo 10 deles os que apresentaram percentualmente o maior crescimento populacional entre os Censos 2010 e 2022 e os 10 que apresentaram decréscimo de população no mesmo período. Verificou-se que a maior nota na EBT foi do município de Canaã dos Carajás/PA, com 9,54, e a menor foi da cidade de Querência/MT, com 4,08. A pontuação média foi de 6,58. A regulamentação da LAI em âmbito municipal foi constatada em 12 municípios. Apenas cinco prefeituras responderam às perguntas feitas via e-SIC. Constatou-se que o nível de transparência não depende do grau de crescimento do município.
PUBLICIDADE ANTIRRACISTA: UM CAMINHO POSSÍVEL PARA REPRESENTAÇÃO DE GÊNERO E RAÇA ATRAVÉS DA MARCA SALON LINE
Authors: David Ernesto Carla Beatriz de , Ferreira Lisboa Filho Flavi
Published: February 2025

Este artigo visa contribuir na amplificação das discussões sobre publicidade antirracista, o objeto definido para o estudo foi o filme publicitário “Celebrando rainhas crespas e cacheadas” da Salon Line. Calcada na análise cultural proposta por Williams (1979; 2003), a metodologia se amparou no conceito de estrutura de sentimento, um dos vértices da Teoria Cultural, assim, analisaremos como os elementos que compõem a estrutura de sentimento, dominante, residual e emergente, auxiliaram a representação da mulher negra no material audiovisual. Inferimos que, na produção, o protagonismo da mulher negra se apresenta a partir dos três pilares da campanha: representação, ancestralidade e poder, ressignificando sentidos e valores. O sistema de representação, apresentado pela marca, agencia a construção de um novo imaginário no que se refere ao resgate da historicidade e representação negra, ou seja, nessa concepção atua o aspecto emergente da estrutura de sentimento, por problematizar as práticas residuais e dominantes da cultura vivida.
EL ECO DE LA VOZ DEL PUEBLO: UN ANÁLISIS DE LA TRANSFORMACIÓN DE LOS SIGNIFICADOS DE LA VOZ ARTÍSTICA EN REPRESENTACIÓN POPULAR
Authors: Soares Thiago Barbosa
Published: February 2025

El objetivo de este artículo es describir e interpretar, a la luz de la bien establecida herramienta interpretativa del análisis del discurso, la transformación de los significados de la voz artística en representación popular. Se eligieron como corpus de investigación los siguientes artículos de 2016 de Brasil de Fato, según el criterio de tener el marcador de voz como parte integrante del texto: “Río: Chico, Lula y 70.000 contra el golpe” (Vieira, 2016), “El hip hop y la periferia no tienen voz sin democracia, dicen artistas” (Ghisi, 2016) y “El arte como resistencia en tiempos de golpe” (Carvalho, 2016). Para ello, se movilizan las nociones de unidad discursiva, condiciones de producción, formación discursiva e interdiscurso. Encontramos recursos utilizados para discursivizar la voz como expresión del cuerpo social, la metaforización, el silenciamiento (Orlandi, 2007) y la nominalización de la voz de sujetos mediáticos exitosos que están en mejores condiciones de aumentar la visibilidad de una determinada causa por la que se lucha.
Mapeamento Bibliométrico da Produção Científica sobre Entrincheiramento Gerencial
Authors: Bubeck Stephan Klaus , Lunardi Micheli Aparecida
Published: February 2025

Este estudo teve como objetivo realizar um mapeamento bibliométrico da produção científica sobre entrincheiramento gerencial com base nas publicações indexadas na plataforma Scopus. Para isso, foram considerados os artigos de língua inglesa publicados em periódicos, compreendendo o período de 1980 a 2022, sendo o mapeamento bibliométrico realizado com o auxílio do software Biblioshiny do RStudio. A seleção dos estudos na base da Scopus foi realizada pela busca da palavra-chave “entrenchment” nos campos título, resumo e palavra-chave. Após o processo de filtragem, a amostra final compreendeu 755 artigos científicos sobre entrincheiramento gerencial. Os principais resultados indicam um crescimento representativo de publicações a partir da década de 2010, sendo a estrutura de propriedade um dos temas centrais a respeito da literatura sobre entrincheiramento gerencial. O autor com o maior número de publicações foi Salehi, já os autores mais citados foram Bebchuk e Lang. O periódico com mais publicações foi o Journal of Corporate Finance, enquanto o mais citado foi o The Journal of Finance. Como contribuição, este estudo oferece uma visão geral da produção científica sobre entrincheiramento gerencial, assim como sugestões de pesquisas futuras que podem ser exploradas. Desse modo, este estudo auxilia como um ponto de partida para acadêmicos e pesquisadores com interesse em se aprofundarem na literatura sobre entrincheiramento gerencial, assim, estimulando a produção de novos trabalhos sobre esse tema.
Desafios de Crescimento em Startups: Estudo de Caso em uma Organização de Educação Digital
Authors: Araújo Amaral Duarte Camilla , Godeiro Chaves Carlos Vanessa , Batista Sales Luciana , Martins de Oliveira Adriana , Meireles de Souza Jocykleber
Published: February 2025

O presente estudo tem como objetivo identificar os fatores de desenvolvimento e os desafios de crescimento de uma Startup de educação digital do estado do Rio Grande do Norte. Para isso, foi realizado um estudo de caso por meio de uma entrevista semiestruturada com o gerente administrativo da organização em foco. Após a transcrição das entrevistas, os dados primários foram importados para o software ATLAS.ti 22. Em seguida, os códigos foram definidos, categorizados e as redes elaboradas. Os resultados mostraram a Startup como promissora diante da mudança do cenário educacional após a pandemia da covid-19. No entanto, também se identificou a presença de fatores adversos ao desenvolvimento organizacional, tais como: dificuldades de acesso às agências de fomento; falhas na divulgação e implementação das políticas públicas de incentivo ao empreendedorismo; falta de networking; ausência de investimento externo; escassez de linhas específicas de crédito bancário para o setor. Observou-se que o contexto pandêmico e a ineficiência dos órgãos governamentais, no que se refere aos incentivos públicos ao empreendedorismo inovador, afetaram negativamente a escalabilidade e o crescimento organizacional. Conclui-se, com este estudo, que a Startup analisada busca atender às demandas do seu público-alvo, mas depende do fortalecimento de redes de apoio para expandir o seu negócio, diante dos desafios enfrentados durante o período pandêmico.
Atenção na Contabilidade! A relação entre a Economia da Atenção e a Qualidade da Informação Contábil
Authors: Santos Rayane Farias dos , Tibúrcio Silva César Augusto
Published: February 2025

O estudo analisou a relação entre a atenção do investidor e a qualidade da informação contábil durante o período do covid-19. Para alcance do objetivo, fez uso do Índice de Volume de Pesquisa (IVP) como proxy para a atenção do investidor, cuja coleta ocorreu por meio do Google Trends. Para medir a qualidade da informação contábil, foi realizada uma coleta de dados e análise de conteúdo por meio de fonte secundária, para a construção do Índice da Qualidade da Informação Contábil (IQIC). Como variáveis de controle foram utilizadas o tamanho, endividamento, auditoria, internacionalização e controle acionário. Os resultados foram obtidos através de regressão quantílica. Observa-se uma associação inconclusiva (negativa no modelo 1 e positiva nos modelos 2 e 4) entre a atenção do investidor e a qualidade da informação contábil nos relatórios financeiros. Quanto as variáveis de controle, o tamanho, a internacionalização e a concentração acionária, impactaram positivamente na qualidade da informação contábil, ao contrário da auditoria, que impactou negativamente. O endividamento não se mostrou significativo a qualidade informacional. Os resultados fornecem perspectivas preciosas para as empresas, investidores e reguladores contábeis. Ainda, aprofunda a compreensão sobre como a atenção do investidor se relaciona com a qualidade da informação contábil, especialmente em situações de crise como a pandemia do covid-19. Adicionalmente, ao considerar variáveis de controle, o estudo enriquece a compreensão dos fatores que que impactam a qualidade da informação contábil em cenários de grande volatilidade e incerteza.
Pesquisa Crítica em Periódicos de Contabilidade no Brasil: Por que a Discussão é Necessária?
Authors: Calado João Eudes Souza , Gonçalves Andrea de Oliveira , Bilhim João Abreu de Faria , Matias-Pereira José
Published: February 2025

Este ensaio objetiva provocar reflexões nos profissionais, acadêmicos, pesquisadores e, sobretudo, editoriais de contabilidade sobre a relevância de estudos críticos publicados em periódicos de contabilidade no Brasil. Estudo qualitativo e descritivo, em formato de ensaio teórico, apresenta uma revisão da literatura em fontes que contribuem para reflexões sobre a história e o estado da arte da pesquisa crítica contábil. Além disso, realiza uma análise comparativa sobre a abertura dos periódicos no Brasil e no exterior, e apresenta as contribuições de editores participantes da Conference Qualitative Research Critical Accounting - Latin America de 2021. Algumas reflexões deste ensaio nos remetem a um aparente atraso no debate crítico contábil no cenário brasileiro, se comparados com os ambientes externos. Apesar de alguns avanços observados, como o crescimento da comunidade de pesquisadores, eventos e espaços de discussão, esses avanços não se refletem em publicações nos periódicos. Sugere-se, portanto, uma investigação futura junto aos editoriais de contabilidade para identificar possíveis causas dessa ausência. Este estudo contribui com a literatura sobre pesquisa crítica contábil, apresentando cenários de debates externos e internos, com o objetivo de instigar a comunidade contábil, especialmente, os editoriais no Brasil para relevância das publicações críticas em contabilidade.
Profissão Contábil e Transformação Digital no Brasil: Uma Revisão da Literatura
Authors: DE MELO WILTON ALEXANDRE
Published: February 2025

O objetivo deste estudo foi conhecer as características dos estudos acadêmicos no Brasil sobre o impacto da transformação digital no desempenho profissional dos contabilistas. Para tanto, o estudo classificou-se como descritivo, com abordagem quantitativa e qualitativa possibilitada pelo uso da análise bibliométrica. De acordo com a análise realizada sobre o título, resumo e palavras-chave, bem como leituras complementares, a amostra da pesquisa foi constituida por 52 (cinquenta e dois) artigos englobando o período de 1996 a setembro de 2024. Os principais resultados mostram que o quantitativo de estudos não ocorrem de forma constante, tendo seu ápice entre 2020 e 2023; Majoritariamente, o número de autores é de três por estudo; não há definição de quem é o pesquisador mais proeminente, nem da revista que mais publica pesquisas relacionadas a temática; evidenciou-se que os pesquisadores são oriundos de diferentes instituições, tendo a UFRGS, a FGV e a USP como sendo as origens mais comuns e, em sua maioria, possuem o título de Doutorado ou Mestrado; não há grande utilização de uma teoria organizacional de base ou outro tipo de teoria na maioria dos estudos; a fonte de dados é a pesquisa direta com dados primários e aplicação de questionário, com enfoque e natureza qualitativa. As principais lacunas de pesquisa foram englobadas em quatro pontos: Educação, melhorias e mudanças na forma de se desenvolver a profissão por meio de tecnologias, empreendedorismo contábil digital e obrigações fiscais acessórias. Conclui-se que há necessidade e espaço para pesquisas na área que envolvam especificamente a Transformação Digital e seu impacto na Contabilidade e na profissão contábil.
Eficiência de Cooperativas de Crédito: uma análise da macrorregião do Triângulo Mineiro e Alto Paranaíba-MG
Authors: Viana Matheus Henrique , Moreira Ney Paulo
Published: February 2025

As cooperativas de crédito brasileiras desempenham um papel importante na democratização de serviços financeiros, facilitando o acesso ao crédito a taxas mais baixas e promovendo o crescimento econômico das suas comunidades. Considerando sua relevância para o desenvolvimento socioeconômico, a gestão eficiente dessas cooperativas é essencial para a continuidade e ampliação dos serviços que oferecem. O objetivo dessa pesquisa é analisar a eficiência das cooperativas de crédito da macrorregião do Triângulo Mineiro e Alto do Paranaíba no período de 2019 a 2022. A pesquisa adota uma abordagem quantitativa, caracteriza-se como descritiva e documental e utiliza relatórios financeiros semestrais do sistema IF.Data. O método estatístico empregado para medir a eficiência é a Análise Envoltória de Dados (DEA). Os resultados indicaram um índice médio de eficiência de 73,06% no primeiro semestre de 2019, 72,54% no segundo semestre de 2019, 73,58% no primeiro semestre de 2020, 73,91% no segundo semestre de 2020, 76,81% no primeiro semestre de 2021, 79,46% no segundo semestre de 2021, 79,82% no primeiro semestre de 2022 e 81,40% no segundo semestre de 2022. Comparando com estudos anteriores, as cooperativas da macrorregião estudada mostraram-se mais eficientes do que as médias mineiras e nacionais, indicando uma evolução positiva na eficiência média em relação a períodos anteriores. As variáveis que apresentaram maiores folgas foram Despesas Administrativas e Sobras e Perdas Acumuladas, representando oportunidades para a melhoria da eficiência na macrorregião. O artigo destaca-se pela contemporaneidade dos dados analisados e por fornecer informações capazes de auxiliar na gestão de cooperativas de crédito.
Lei Geral de Proteção de Dados: Compliance nos Escritórios Contábeis do Recôncavo Baiano
Authors: Ferreira Alison Silva , Da Cruz Oliveira Nverson , Dos Santos Silva Luiz Ivan
Published: February 2025

O objetivo deste estudo foi verificar se os fatores de perfil empresarial contribuem para que os escritórios de contabilidade do Recôncavo Baiano se adequem a Lei Geral de Proteção de Dados. Neste sentido, através de questionário como instrumento de coleta de dados, obteve-se informações de 55 escritórios de contabilidade da região do recôncavo baiano a respeito do grau de adequação dos mesmos à LGPG. A partir dos dados coletados,  infere-se um nível de adequação geral igual a 3,33 de uma escala de 1 a 5 para a amostra analisada. Mediante aplicação de regressão múltipla, os resultados também mostram que, as variáveis Tempo de Funcionamento; Porte; Quantidade de Funcionários e; Concorrência, são explicativas do grau de adequação dos escritórios de contabilidade do recôncavo baiano a um nível de 56,08%, conforme apresentado pelo coeficiente R² da equação. Contudo, as variáveis de Porte e Concorrência apresentam relação inversamente proporcional ao grau de adequação à LGPD, destacando a necessidade de maior atenção a fim de melhorar a conformidade com a LGPD. Dessa forma, atendendo aos regulamentos, espera-se que os escritórios de contabilidade implementem sistemas de proteção de modo para evitar a exposição e compartilhamento indevido de informações, a partir da adoção de mecanismos de governança corporativa de dados.
Associação da Governança Corporativa com a Remuneração e a Opinião dos Auditores em Bancos Brasileiros
Authors: Mendonça Queiroz Vaz Clara , Arthur Souza Alves Paulo , Alves Dantas José
Published: February 2025

Este estudo teve por objetivo avaliar a associação dos níveis de governança corporativa nos bancos brasileiros com a remuneração dos auditores, considerando os efeitos risco ou demanda, e a opinião de auditoria sobre as demonstrações financeiras. Os testes empíricos, baseados em dados de formulários de referência e relatórios de auditoria, de 2009 a 2022, de 25 bancos listados na B3 revelaram resultados variados em relação à remuneração. Para a remuneração nominal não foi constatada relação com a governança corporativa, enquanto foi documentada associação positiva entre a remuneração relativa e o nível de governança, confirmando a expectativa de que estrutura de governança mais sólida é relacionada com maiores honorários de auditoria, em linha com o denominado efeito demanda. Além disso, os resultados indicaram que bancos listados em segmentos especiais de governança da B3 têm menor probabilidade de apresentar relatórios de auditoria com opiniões modificadas, sugerindo que esses bancos, por observarem regras mais robustas de governança e controle, tendem a preparar informações mais confiáveis, resultando em menor probabilidade de modificação na opinião sobre as demonstrações financeiras. As evidências empíricas contribuem para a compreensão dos efeitos da governança corporativa no processo de auditoria, fornecendo informações significativas para reguladores, gestores e investidores sobre como os auditores reagem à instituição de mecanismos de controle e governança.
What Is Bipolar Disorder?
Authors: Voelker Rebecca
Published: February 2024

This JAMA Patient Page describes bipolar disorder: diagnosis, treatment, and prognosis.
The Pregnant Workers Fairness Act—a Bipartisan Step Forward
Authors: Adashi Eli Y. , O’Mahony Daniel P. , Cohen I. Glenn
Published: February 2024

This Viewpoint describes key provisions of the Pregnant Workers Fairness Act and discuss the proposed Equal Employment Opportunity Commission rule, as well as its application to health care employment in particular.
Macrophage‐1 antigen exacerbates histone‐induced acute lung injury and promotes neutrophil extracellular trap formation
Authors: Mizuno Tomohiro , Nagano Fumihiko , Takahashi Kazuo , Yamada Shigeki , Fruhashi Kazuhiro , Maruyama Shoichi , Tsuboi Naotake
Published: February 2024

Acute lung injury (ALI), which occurs in association with sepsis, trauma, and coronavirus disease 2019 (COVID‐19), is a serious clinical condition with high mortality. Excessive platelet‐leukocyte aggregate (PLA) formation promotes neutrophil extracellular trap (NET) release and thrombosis, which are involved in various diseases, including ALI. Macrophage‐1 antigen (Mac‐1, CD11b/CD18), which is expressed on the surface of leukocytes, is known to promote NET formation. This study aimed to elucidate the role of Mac‐1 in extracellular histone‐induced ALI. Exogenous histones were administered to Mac‐1‐deficient mice and wild‐type (WT) mice with or without neutrophil or platelet depletion, and several parameters were investigated 1 h after histone injection. Depletion of neutrophils or platelets improved survival time and macroscopic and microscopic properties of lung tissues, and decreased platelet‐leukocyte formation and plasma myeloperoxidase levels. These improvements were also observed in Mac‐1−/− mice. NET formation in Mac‐1−/− bone marrow neutrophils (BMNs) was significantly lower than that in WT BMNs. In conclusion, our findings suggest that Mac‐1 is associated with exacerbation of histone‐induced ALI and the promotion of NET formation in the presence of activated platelets.
Guiding Stem Cell Tenogenesis by Modulation of Growth Factor Signaling and Cell‐Scale Biophysical Cues in Bioengineered Constructs
Authors: Teixeira Simão P. B. , Pardo Alberto , Bakht Syeda M. , Gomez‐Florit Manuel , Reis Rui L. , Gomes Manuela E. , Domingues Rui M. A.
Published: February 2024

Tendon injuries and tendinopathies are increasingly prevalent health problems currently lacking effective treatments. Tissue engineering offers promising strategies to boost the low innate regenerative ability of tendons. Within this context, the simultaneous leveraging of both physical and biochemical cues by engineered scaffolding systems can be explored to promote a stronger tenogenic response from stem cells. Here, molecularly imprinted polymeric nanoparticles (MINPs) against transforming growth factor (TGF)‐β3 are combined with bioinspired anisotropic hydrogels to produce tenogenesis‐inductive constructs. MINPs are first solid phase‐imprinted against a TGF‐β3 epitope, achieving an affinity comparable to monoclonal antibodies. MINPs and magnetically‐responsive microfibers are then encapsulated together with adipose‐derived stem cells within gelatin‐based hydrogels, applying a magnetostatic field during gelation to align the microfibers. The created anisotropic microstructure guides cell growth and elongation unidirectionally, while MINPs act as artificial receptors for TGF‐β3, potentiating its paracrine action in the cellular microenvironment. The combination of both stimuli proves effective at increasing TGF‐β signaling, which promotes the expression of tendon‐associated genes and corresponding protein synthesis, suggesting that microstructural cues and biomolecule sequestration act in tandem to direct cell fate commitment. Overall, this system recapitulates several elements of tendon development, constituting a promising strategy for the regeneration of this tissue.
Lipid Microfluidic Biomimetic Models for Drug Screening: A Comprehensive Review
Authors: Fernandes Eduarda , Cardoso Vanessa F. , Lanceros‐Méndez Senentxu , Lúcio Marlene
Published: February 2024

Developing new drugs is a complex, time‐consuming, and expensive process, essential to identify potential pharmacokinetic issues in the early stages to avoid investment in nonpromising candidates. Nearly half of all drug targets and key drug‐metabolizing enzymes are found in intracellular environments, compartmentalized by semipermeable barriers, the cell membranes. Inspired by their lipidic bilayer structure, lipid‐based biomimetic platforms are being developed to understand the biochemical and biophysical processes at the cellular membrane level. Considering the pharmaceutical industry's demands for efficient in vitro high throughput screening tools, microfluidic technology emerges as a promising solution to address challenges in lipid biomimetic models for screening applications. This involves the transformation of commonly used lipid‐based biomimetic models, like supported lipid bilayers and lipid vesicles, to miniaturized approachs and their evolution into a new generation of bilayer models. These include pore‐suspended and free‐standing lipid bilayers, black lipid membranes, and droplet interface bilayers. This review provides an overview of both generations of lipid biomimetic models used in drug‐membrane screening applications. Moreover, it delves into the intricacies of their production through microfluidic approaches and examines their screening applications in drug‐membrane interaction. The review concludes with a critical analysis of potential future directions in this rapidly evolving field.
Synthesis and Chiroptical Properties of Radially Extended Carbazole with Chiral [2.2]Paracyclophane Core
Authors: Hasegawa Masashi , Xiao Wanli , Ishida Yuki , Asahi Kazuyuki , Nishikawa Hiroyuki , Ohno Reo , Hayauchi Daisuke , Hasegawa Miki , Mazaki Yasuhiro
Published: February 2024

[2.2]Paracyclophanes ([2.2]PCs) with substituents at specific positions possesses planar chirality and stands as a promising building unit for the development of chiroptical materials associated with polarized light. However, one of the easily accessible starting materials, bromo‐substituted [2.2]PC, shows low reactivity, and effective methods for π‐extension of planar chiral [2.2]PC are limited. Herein, an effective π‐extension method has established for chiral [2.2]PC with four substitutions from 4,7,12,15‐tetrabromo[2.2]PC. This has led to tetrakis(trimethylsilylphenyl)‐[2.2]PC that serves as a versatile building resource for radial‐type chiral π‐conjugated compounds with a [2.2]PC core. In this study, synthesizing compounds are further succeeded with the introduction of carbazole (Cbz4‐[2.2]PC and tBuCbz4‐[2.2]PC) and investigated their chiroptical properties and chiral induction ability in achiral π‐conjugated polymers. A thin film of [Poly[9,9‐dioctylfluorenyl‐2,7‐diyl)‐alt‐(benzo[2,1,3]thiadiazol‐4,7‐diyl)]] (F8BT) with 3wt% Cbz4‐[2.2]PC prepared by spin‐coating exhibits circularly polarized luminescence (CPL) properties with a high dissymmetry factor (|glum| = 0.01), which is much higher than that of Cbz4‐[2.2]PC in CH2Cl2 solution. By contrast, the doped film of F8BT with 3wt% tBuCbz4‐[2.2]PC exhibited only weak CPL properties. In addition, these chiral compounds show facile redox properties owing to the presence of carbazole units. Furthermore, Cbz4‐[2.2]PC undergoes electropolymerization to produce an insoluble thin film on the electrode.
Revealing the Role of Binary Distortion in PMS Activation over Spinel toward Efficient New Pollutants Removal
Authors: Wang Pengfei , Zhao Zhiyong , Zhang Lijun , Zhan Sihui , Li Yi
Published: February 2024

Improving peroxymonosulfate (PMS) activation efficiency to enhance simultaneous generation of radicals and non‐radicals is essential for removing new pollutants (NPs) in complex waters. However, achieving this with standard lattice‐structured heterogeneous catalysts remains challenging due to inefficient electron transfer. Here, CuCo2O4 properties are successfully tuned by controlling lattice distortion, enabling simultaneous PMS oxidation and reduction. Unlike the slow rate of electron transfer in heterogeneous metal catalysts with standard lattice structures, the highly active binary lattice distortion in CuCo2O4 alters the structure and electron distribution, exposes more Cu and Co sites, lowers the PMS adsorption barriers, and realizes the synergistic production of SO4•−/•OH), and 1O2. The k‐value for ciprofloxacin is as high as 17.83 min−1 M−1, 29.42 times higher than that with non‐binary lattice distortion. Additionally, the developed intermittent reactor consistently maintains a removal rate above 95% over five cycles in actual wastewater treatment scenarios. This work provides a new avenue for achieving the removal of new pollutants in complex water bodies.
3D Printing of Cobalt‐Incorporated Chloroapatite Bioceramic Composite Scaffolds with Antioxidative Activity for Enhanced Osteochondral Regeneration
Authors: Shu Chaoqin , Qin Chen , Wu Aijun , Wang Yufeng , Zhao Chaoqian , Shi Zhe , Niu Huicong , Chen Jiajie , Huang Jimin , Zhang Xinxin , Huan Zhiguang , Chen Lei , Zhu Min , Zhu Yufang
Published: February 2024

Osteochondral defects are often accompanied by excessive reactive oxygen species (ROS) caused by osteoarthritis or acute surgical inflammation. An inflammatory environment containing excess ROS will not only hinder tissue regeneration but also impact the quality of newly formed tissues. Therefore, there is an urgent need to develop scaffolds with both ROS scavenging and osteochondral repair functions to promote and protect osteochondral tissue regeneration. In this work, by using 3D printing technology, a composite scaffold based on cobalt‐incorporated chloroapatite (Co‐ClAP) bioceramics, which possesses ROS‐scavenging activity and can support cell proliferation, adhesion, and differentiation, is developed. Benefiting from the catalytic activity of Co‐ClAP bioceramics, the composite scaffold can protect cells from oxidative damage under ROS‐excessive conditions, support their directional differentiation, and simultaneously mediate an anti‐inflammatory microenvironment. In addition, it is also confirmed by using rabbit osteochondral defect model that the Co‐ClAP/poly(lactic‐co‐glycolic acid) scaffold can effectively promote the integrated regeneration of cartilage and subchondral bone, exhibiting an ideal repair effect in vivo. This study provides a promising strategy for the treatment of defects with excess ROS and inflammatory microenvironments.
Silver Mineralized Protein Hydrogel with Intrinsic Cell Proliferation Promotion and Broad‐Spectrum Antimicrobial Properties for Accelerated Infected Wound Healing
Authors: Wang Weiqiang , Chu Fengjiao , Zhang Weifeng , Xiao Tingting , Teng Jingjing , Wang Yan , He Bo , Ge Binghui , Gao Jiajia , Ge Honghua
Published: February 2024

The presence of multidrug‐resistant bacteria has challenged the clinical treatment of bacterial infection. There is a real need for the development of novel biocompatible materials with broad‐spectrum antimicrobial activities. Antimicrobial hydrogels show great potential in infected wound healing but are still being challenged. Herein, broad‐spectrum antibacterial and mechanically tunable amyloid‐based hydrogels based on self‐assembly and local mineralization of silver nanoparticles are reported. The mineralized hydrogels are biocompatible and have the advantages of sustained release of silver, prolonged antimicrobial effect, and improved adhesion capacity. Moreover, the mineralized hydrogels display a significant antimicrobial effect against both Gram‐positive and Gram‐negative bacteria in cells and mice by inducing membrane damage and reactive oxygen species toxicity in bacteria. In addition, the mineralized hydrogels can rapidly accelerate wound healing by the synergy between their antibacterial activity and intrinsic improvement for cell proliferation and migration. This study provides a modular approach to developing a multifunctional protein hydrogel platform based on biomolecule‐coordinated self‐assembly for a wide range of biomedical applications.
A‐D‐A Molecule–Bridge Interface for Efficient Perovskite Solar Cells and Modules
Authors: Duan Lianjie , Zheng Dexu , Farhadi Bita , Wu Sajian , Wang Hao , Peng Lei , Liu Lu , Du Minyong , Zhang Youdi , Wang Kai , Liu Shengzhong
Published: February 2024

As the photovoltaic field endeavors to transition perovskite solar cells (PSCs) to industrial applications, inverted PSCs, which incorporate fullerene as electron transport layers, have emerged as a compelling choice due to their augmented stability and cost‐effectiveness. However, these attributes suffer from performance issues stemming from suboptimal electrical characteristics at the perovskite/fullerene interface. To surmount these hurdles, an interface bridging strategy (IBS) is proposed to attenuate the interface energy loss and enhance the interfacial stability by designing a series of A‐D‐A type perylene monoimide (PMI) derivatives with multifaceted advantages. In addition to passivating defects, the IBS plays a crucial role in facilitating the binding between perovskite and fullerene, thereby enhancing interface coupling and importantly, improving the formation of fullerene films. The PMI derivatives, functioning as bridges, serve as a protective barrier to enhance the device stability. Consequently, the IBS enables a remarkable efficiency of 24.62% for lab‐scale PSCs and an efficiency of 18.73% for perovskite solar modules craft on 156 × 156 mm2 substrates. The obtained efficiencies represent some of the highest recorded for fullerene‐based devices, showcasing significant progress in designing interfacial molecules at the perovskite/fullerene interface and offering a promising path to enhance the commercial viability of PSCs.
Practical Applications of Self‐Healing Polymers Beyond Mechanical and Electrical Recovery
Authors: Kim Semin , Jeon Hyeonyeol , Koo Jun Mo , Oh Dongyeop X. , Park Jeyoung
Published: February 2024

Self‐healing polymeric materials, which can repair physical damage, offer promising prospects for protective applications across various industries. Although prolonged durability and resource conservation are key advantages, focusing solely on mechanical recovery may limit the market potential of these materials. The unique physical properties of self‐healing polymers, such as interfacial reduction, seamless connection lines, temperature/pressure responses, and phase transitions, enable a multitude of innovative applications. In this perspective, the diverse applications of self‐healing polymers beyond their traditional mechanical strength are emphasized and their potential in various sectors such as food packaging, damage‐reporting, radiation shielding, acoustic conservation, biomedical monitoring, and tissue regeneration is explored. With regards to the commercialization challenges, including scalability, robustness, and performance degradation under extreme conditions, strategies to overcome these limitations and promote successful industrialization are discussed. Furthermore, the potential impacts of self‐healing materials on future research directions, encompassing environmental sustainability, advanced computational techniques, integration with emerging technologies, and tailoring materials for specific applications are examined. This perspective aims to inspire interdisciplinary approaches and foster the adoption of self‐healing materials in various real‐life settings, ultimately contributing to the development of next‐generation materials.
Dissipation of pendimethalin in a water‐seeded rice field and implications for water management
Authors: Becerra‐Alvarez Aaron , Al‐Khatib Kassim
Published: February 2024

Water‐seeded rice (Oryza sativaL.) in California is produced near growing urban centers and a variety of neighboring high‐value crops, which make water quality a paramount concern because of potential herbicide residue contamination in downstream surface waters. Pendimethalin is a potential herbicide for use in California water‐seeded rice. A study was conducted to characterize pendimethalin's dissipation in water of a water‐seeded rice field. A capsule suspension (CS), emulsifiable concentrate (EC), and granule (GR) pendimethalin were applied onto flooded rice plots at 1.1, 2.3, and 3.4 kg ai ha−1rates. Water samples were collected periodically and analyzed with an high pressure liquid chromatography tandem mass spectrometry system for residues. Pendimethalin dissipation differed across formulations. The initial sampled concentrations recorded values from 3.0 to 125.6 parts per billion (ppb). First‐order dissipation resulted in half‐lives for the CS from 2.3 to 3.5 days, the EC from 0.6 to 0.7 days, and the GR from 3.5 to 6.9 days. Pendimethalin use in water‐seeded rice is at low risk of contaminating downstream surface waters; however, early sampled residue concentrations could be concerning. The results can assist in generating management tactics like water‐holding periods to avoid potential downstream off‐target effects and ensure herbicidal activity in the applied area after a pendimethalin application in a water‐seeded rice field.
Anti‐aging effects of icariin and the underlying mechanisms: A mini‐review
Authors: Li Ying , Wei Zhi‐Feng , Su Long
Published: February 2024

Aging is an extremely intricate and progressive phenomenon that is implicated in many physiological and pathological conditions. Icariin (ICA) is the main active ingredient of Epimedium and has exhibited multiple bioactivities, such as anti‐tumor, neuroprotective, antioxidant, anti‐inflammatory, and anti‐aging properties. ICA could extend healthspan in both invertebrate and vertebrate models. In this review, the roles of ICA in protection from declined reproductive function, neurodegeneration, osteoporosis, aging intestinal microecology, and senescence of cardiovascular system will be summarized. Furthermore, the underlying mechanisms of ICA‐mediated anti‐aging effects will be introduced. Finally, we will discuss some key aspects that constrain the usage of ICA in clinical practice and the corresponding strategies to solve these issues.
Quantum chemical calculation driven insights into deep eutectic solvent‐accelerated photoinduced reversible complexation‐mediated polymerization
Authors: Li Shen , Fu Xin , Zhou Yin‐Ning , Liu Zhong‐Xin , Hou Lin‐Xi , Luo Zheng‐Hong
Published: February 2024

Deep eutectic solvent (DES) is used as both photocatalyst and solvent for photoinduced reversible complexation‐mediated polymerization (photo‐RCMP), which enables a rapid polymerization to produce polymers with predictable molar mass and low molar mass dispersity (Đ). This work illustrates a comprehensive understanding of DES‐accelerated RCMP's mechanism and kinetic features through quantum chemical calculations and kinetic modeling. According to the results, electrons transferring from hydrogen bond in DES to iodine atom in alkyl iodide (RI) initiator under light irradiation lowers the decomposition free energy of complex RI‐DES. This procedure facilitates the generation of primary radicals, thus contributing to the DES‐accelerated phenomenon. In the meantime, the reaction paths are identified by computation as (i) decomposition of RI‐DES under light irradiation generates active radicals and ·I‐DES complex and (ii) combination of two ·I‐DES releases iodine (I2) and regenerates DES. In addition, kinetic modeling based on the method of moments successfully identifies kinetic features of polymerization in the presence and absence of DES, respectively. Kinetic modeling shows a fast increase in primary radicals concentration and rapid build‐up of the photo‐RCMP activation‐deactivation equilibrium, demonstrating that DES is a beneficial photocatalyst and solvent to enable the rapid generation of primary radicals and accelerate the completion of catalytic cycle. This research provides an in‐depth understanding of DES‐involved photo‐RCMP and lays a theoretical foundation for expanding the application of DES to other polymerization systems.
Intensive Blood Pressure Treatment and Subclinical Brain Infarcts: A Secondary Analysis of SPRINT (Systolic Pressure Intervention Trial)
Authors: Kern Kyle C. , Nasrallah Ilya M. , Bryan R. Nick , Williamson Jeff , Reboussin David M. , Pajewski Nicholas M. , Wright Clinton B.
Published: February 2024

Objective

Subclinical brain infarcts (SBI) increase the risk for stroke and dementia, but whether they should be considered equivalent to symptomatic stroke when determining blood pressure targets remains unclear. We tested whether intensive systolic blood pressure (SBP) treatment reduced the risk of new SBI or stroke and determined the association between SBI and cognitive impairment.

Methods

In this secondary analysis of SPRINT (Systolic Pressure Intervention Trial), participants ≥50 years old, with SBP 130–180mmHg and elevated cardiovascular risk but without known clinical stroke, dementia, or diabetes, were randomized to intensive (<120mmHg) or standard (<140mmHg) SBP treatment. Brain magnetic resonance images collected at baseline and follow‐up were read for SBI. The occurrence of mild cognitive impairment (MCI) or probable dementia (PD) was evaluated.

Results

For 667 participants at baseline, SBI were identified in 75 (11%). At median 3.9 years follow‐up, 12 of 457 had new SBI on magnetic resonance imaging (5 intensive, 7 standard), whereas 8 had clinical stroke (4 per group). Baseline SBI (subhazard ratio [sHR] = 3.90; 95% CI 1.49 to 10.24; p = 0.006), but not treatment group, was associated with new SBI or stroke. For participants with baseline SBI, intensive treatment reduced their risk for recurrent SBI or stroke (sHR = 0.050; 95% CI 0.0031 to 0.79; p = 0.033). Baseline SBI also increased risk for MCI or PD during follow‐up (sHR = 2.38; 95% CI 1.23 to 4.61; p = 0.010).

Interpretation

New cerebral ischemic events were infrequent, but intensive treatment mitigated the increased risk for participants with baseline SBI, indicating primary prevention SBP goals are still appropriate when SBI are present. ANN NEUROL 2024;95:866–875
Anionic Sublattices in Halide Solid Electrolytes: A Case Study with the High‐Pressure Phase of Li3ScCl6
Authors: Ding Fenghua , Doi Atsunori , Ogawa Takafumi , Ubukata Hiroki , Zhu Tong , Kato Daichi , Tassel Cédric , Oikawa Itaru , Inui Naoki , Kuze Satoru , Yamabayashi Tsutomu , Fujii Kotaro , Yashima Masatomo , Ou Xing , Wang Zhijian , Min Xiaobo , Fujita Koji , Takamura Hitoshi , Kuwabara Akihide , Zhang Tianren , Griffith Kent J. , Lin Zhang , Chai Liyuan , Kageyama Hiroshi
Published: February 2024

The Li3MX6 compounds (M=Sc, Y, In; X=Cl, Br) are known as promising ionic conductors due to their compatibility with typical metal oxide cathode materials. In this study, we have successfully synthesized γ‐Li3ScCl6 using high pressure for the first time in this family. Structural analysis revealed that the high‐pressure polymorph crystallizes in the polar and chiral space group P63mc with hexagonal close‐packing (hcp) of anions, unlike the ambient‐pressure α‐Li3ScCl6 and its spinel analog with cubic closed packing (ccp) of anions. Investigation of the known Li3MX6 family further revealed that the cation/anion radius ratio, rM/rX, is the factor that determines which anion sublattice is formed and that in γ‐Li3ScCl6, the difference in compressibility between Sc and Cl exceeds the ccp rM/rX threshold under pressure, enabling the ccp‐to‐hcp conversion. Electrochemical tests of γ‐Li3ScCl6 demonstrate improved electrochemical reduction stability. These findings open up new avenues and design principles for lithium solid electrolytes, enabling routes for materials exploration and tuning electrochemical stability without compositional changes or the use of coatings.
WH‐Überseequartier in Hamburg – Ingenieurbauwerke und Gründung
Authors: Schadow Thomas , Jansson Nicodemus
Published: February 2024

Das zweiseitig am Wasser liegende neue Zentrum WH‐Überseequartier des Stadtteils HafenCity in Hamburg befindet sich nach wechselvoller Geschichte kurz vor der Fertigstellung. Investor, Bauherr und Betreiber des neuen Quartiers mit insgesamt 419.000 m2 Bruttogrundfläche ist das Unternehmen Unibail‐Rodamco‐Westfield. Insgesamt wurden im Quartier 14 aufgehende Gebäude nach Entwürfen nahmhafter Architekturbüros realisiert. In diesem Bericht werden die Herausforderungen der Planung und Umsetzung der vielfältigen, im Quartier notwendigen Ingenieurbauwerke von den Baugruben, dem Umgang mit dem mitten im Baufeld liegenden Haltestellenbauwerk der U‐Bahn, dem erforderlichen Teilersatzneubau des Chicagokais bis zu den Gründungen der neuen Hochbauten und Außenanlagen beschrieben. Im zu einem späteren Zeitpunkt folgenden zweiten Teil werden die Tragwerke der sehr unterschiedlich genutzten Hochbauten aus Sicht der Planung und Bauausführung zusammengestellt.
Longevity Spinach (Gynura procumbens) Ameliorated Oxidative Stress and Inflammatory Mediators in Cisplatin‐Induced Organ Dysfunction in Rats: Comprehensive in vivo and in silico Studies
Authors: Chandra Shill Manik , El‐Nashar Heba A. S. , Prova Mollick Patricia , Nath Acharyya Rabindra , Afrin Silvia , Hossain Hemayet , Halder Shimul , Torequl Islam Muhammad , Bhuia Md. Shimul , Reza Hasan Mahmud , El‐Shazly Mohamed , Mubarak Mohammad S.
Published: February 2024

This study focused to assess the efficacy of Gynura procumbens (GP) leaf extract against cisplatin (CP)‐induced hepatorenal complications in Wister albino rats. Additionally, it aims to detect polyphenolic compounds using high‐performance liquid chromatography with diode‐array detection (HPLC‐DAD). The rats were treated intraperitoneally with CP (7.5 mg/kg) to mediate hepatorenal damage. They were then treated with GP extract (75 and 150 mg/kg, P.O.) for 7 consecutive days. Although GP extract significantly ameliorated CP‐mediated hepatorenal biomarkers like alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), creatinine, and blood urea nitrogen (BUN) levels in a dose‐dependent manner, GP extract at 150 mg/kg dose normalized hepatorenal biomarkers ALP (45.11 U/L), ALT (34 U/L), AST (29 U/L), creatinine (10.3 mg/dl) and BUN (11.19 mg/dl) while comparing to control and disease group. Similarly, though it significantly reduced CP‐induced oxidative stress inducers, including nitric oxide (NO) and advanced oxidative protein products (AOPP), higher dose (150 mg/kg) exhibited better activity in reducing NO (281.54 mmol/gm tissue in liver and 52.73 mmol/gm tissue in the kidney) and AOPP (770.95 mmol/mg protein in liver and 651.90 mmol/mg protein in the kidney). Besides, it showed better enhancement in the antioxidant enzymes superoxide dismutase, and glutathione levels at a higher dose (150 mg/kg). Histopathological studies showed that CP caused collagen accumulation in the liver and kidney tissues. GP extract drained the collagen mass and acted against hepatorenal damage. Ellagic acid, gallic acid, quercetin hydrate, kaempferol, and rutin hydrate were revealed in GP extract. In‐silico modelling showed good docking scores of the polyphenolic compounds with molecular targets including CYP4502E1, NF‐κB, caspase‐3, and TNF‐α. GP could be an effective therapeutic option for management of anticancer drugs’ complications like CP‐induced organ damage, although clinical studies are required to establish herbal formulation.
Design and Synthesis of Novel Phthalide Derivatives containing 1,3,4‐Oxadiazole/1,2,4‐Triazole Units as Potential Antifungal Agents
Authors: Li Yong , Luo Zhongfu , Liu Wenjing , Chen Wenzhang , Wang Jianta , Zhu Gaofeng , Guo Bing , Tang Lei , Fan Lingling
Published: February 2024

Four series of novel 1,3,4‐oxadiazole/1,2,4‐triazole hybrids of phthalide derivatives were designed and synthesized to search for novel potential antifungal agents. Preliminary antifungal activity assay results showed that compounds 4 a, 4 b, 4 m, 5 b, 5 f, 5 h, and 7 h exhibited moderate to excellent inhibitory activity against some phytopathogenic fungi. Among them, compound 5 b displayed the most outstanding antifungal effects against V. mali and S. sclerotiorum, with the EC50 mean of 3.96 μg/mL and 5.60 μg/mL, respectively, which was superior to those of commercial fungicides hymexazol and chlorothalonil. Furthermore, compound 5 b could completely suppress the spore germination of V. mali at a concentration of 10 μg/mL. Finally, molecular docking revealed that the potential target for the antifungal activity of compound 5 b was succinate dehydrogenase (SDH). This research provides novel candidate compounds for the prevention of phytopathogenic fungi.
Light‐Activatable Photocaged UNC2025 for Triggering TAM Kinase Inhibition in Bladder Cancer
Authors: Breton‐Patient Chloé , Billotte Sébastien , Duchambon Patricia , Fontaine Gaëlle , Bombard Sophie , Piguel Sandrine
Published: February 2024

Photopharmacology is an emerging field that utilizes photo‐responsive molecules to enable control over the activity of a drug using light. The aim is to limit the therapeutic action of a drug at the level of diseased tissues and organs. Considering the well‐known implications of protein kinases in cancer and the therapeutic issues associated with protein kinase inhibitors, the photopharmacology is seen as an innovative and alternative solution with great potential in oncology. In this context, we developed the first photocaged TAM kinase inhibitors based on UNC2025, a first‐in‐class small molecule kinase inhibitor. These prodrugs showed good stability in biologically relevant buffer and rapid photorelease of the photoremovable protecting group upon UV‐light irradiation (<10 min.). These light‐activatable prodrugs led to a 16‐fold decrease to a complete loss of kinase inhibition, depending on the protein and the position at which the coumarin‐type phototrigger was introduced. The most promising candidate was the N,O‐dicaged compound, showing the superiority of having two photolabile protecting groups on UNC2025 for being entirely inactive on TAM kinases. Under UV‐light irradiation, the N,O‐dicaged compound recovered its inhibitory potency in enzymatic assays and displayed excellent antiproliferative activity in RT112 cell lines.