bluuebunny/crossref_metadata_2025 huggingface dataset:
Tree Leaf Extracts as Biostimulants for influencing Germination Attributes and Biochemical Changes in kodo millet (Paspalum scrobiculatum L.)
Authors:   Ph.D. Scholar (Agronomy), AC&RI, TNAU, Madurai, K Sangeetha , C Swaminathan ,   Professor (Agronomy), AC&RI, TNAU, Coimbatore, E Subramanian ,   Assistant Professor (Agronomy), AC&RI, TNAU, Killikulam, P Kannan ,   Assistant Professor (Soil science), AC&RI, TNAU, Madurai, R Sivasankari ,   Associate Professor (Mathematics), AC&RI, TNAU, Madurai
Published: July 2022

This study was performed at the Agricultural College and Research Institute, Tamil Nadu Agricultural University, Madurai-625104, India with a primary objective of evaluating the effectiveness of natural botanicals/tree leaf extracts of three horticultural tree species on germination and associated features in kodo millet and, in coordination with bioassay investigations, biochemical analysis of leaf extracts and enzyme activities in kodo millet. Response Index was computed for comparison and the reasons for the effect, if any, was investigated by GCMS-based identification of the chemicals found in the leaf extracts. The findings showed that treating the seeds with mango leaf extract boosted the seedling vigour index in kodo millet. In addition, the higher response on germination and enzyme activities such as dehdrogenase, α Amylase, catalyse and peroxidase in kodo millet were documented in Moringa oleifera leaf extract. Key words: Bioassay, Mango leaf extract, Moringa oleifera, Germination, kodo millet
OPIUM AND ITS MAJOR ALKALOIDAL CONSTITUENTS: A REVIEW ARTICLE
Authors:   School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041, Devi Rajni , Khan Bahadur ,   School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041, Bala Madhu ,   School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041, Pathania Kanika ,   School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041, Thakur Kiran ,   School of Pharmacy, Career Point University, Hamirpur, Himachal Pradesh, INDIA 176041
Published: July 2022

Poppy (Papaver somniferous L.) is a member of the Papaveraceous family. It is indigenous ofsouth east of Europe and Asia. It is cultivated all over the world and there is not any wild type of this species. It is widely grown as an ornamental flower throughout Europe, North America, South America, and Asia. Until now more than 40 different alkaloids have been known in thisspecies which the most important ones are morphine, codeine, thebaine, papaverine and noscapine. Alkaloids are affected with genetical characteristics and environmental conditions. Poppy seeds are an important food item and the source of poppy seed oil, healthy edible oilthat has many uses. The most important application of papaver alkaloids is due to their analgesic properties. Use of opium poppy (Papaver somniferum L.) as a medicinal plant hasbeen described in the ancient literature of Indian system of medicine (Ayurveda). Keyword: - Opium, Alkaloids, Morphine, Codeine, Medicinal plants
Impactul infecţiei cu Staphylococcus aureus asupra evoluţiei fibrozei chistice la copiii dintr-un centru regional din nord-estul României
Authors:   Clinica III Pediatrie, Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România, Anton-Pǎduraru Dana-Teodora , Moscalu Mihaela ,   Departamenul Informaticǎ Medicalǎ şi Biostatisticǎ, Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România, Coman Gabriela ,   Laborator – Spitalul de Urgenţǎ pentru copii „Sf. Maria“, Iaşi, România, Florescu Laura ,   Disciplina Puericulturǎ, Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România, Trandafir Laura-Mihaela ,   Clinica III Pediatrie, Universitatea de Medicinǎ şi Farmacie „Gr. T. Popa“, Iaşi, România
Published: July 2022

Introducere. Infecţiile bacteriene cronice şi, adesea, exacerbările infecţioase acute sunt caracteristice bolii pulmonare din fibroza chistică (FC). Obiectivul studiului a fost reprezentat de identificarea copiilor cu FC, depistarea infecţiei cu Staphylococcus aureus la aceşti bolnavi şi cuantificarea impactului infecţiei asupra statusului clinic. Material şi metodă. S-a realizat un studiu prospectiv pe o perioadă de 3 ani pe un lot de 37 de copii cu FC aflaţi în evidenţa Centrului Regional din Clinica III Pediatrie Iaşi, România. La aceşti bolnavi s-a urmărit prezenţa S. aureus, prevalenţa tulpinilor de S. aureus meticilino-rezistente (SAMR), impactul infecţiei cronice cu SAMR asupra funcţiei pulmonare concomitent cu prezenţa unor elemente de severitate în FC. Rezultate. 22 de pacienţi dintre cei 37 cu FC au prezentat culturi pozitive pentru S. aureus; la 9 dintre aceştia s-a izolat SAMR, 5 având infecţie cronicǎ. Grupul SAMR pozitiv a prezentat valori semnificativ mai mici ale volumului de gaz expirat în prima secundǎ a expirului forţat (FEV1), status nutriţional mai precar, bronşiectazii severe, un număr mai mare de exacerbări pulmonare şi implicit de spitalizări, insuficienţă pancreatică în majoritatea cazurilor şi o asociere mai mare cu genotipul F508del. Concluzii. S. aureus rămâne un patogen important în FC. Din cauza patogenicităţii sale crescute, S. aureus şi în special tulpinile SAMR pot contribui la evoluţie clinică nefavorabilă.
Utilitatea măsurării feNO în monitorizarea copiilor cu astm bronşic
Authors:   Clinica II Pediatrie IOMC „Prof. Dr. Alfred Rusescu“, Bucureşti, România, Popescu Cristina , Craiu Mihai ,   Clinica II Pediatrie IOMC „Prof. Dr. Alfred Rusescu“, Bucureşti, România
Published: July 2022

Scopuri şi obiective. Astmul bronşic este cea mai frecventă boală cronică la copii. În peste 50% din cazurile pediatrice, inflamaţia căilor aeriene este eozinofilică. În monitorizarea astmului, cel mai important aspect este prevenirea exacerbărilor printr-o bună comunicare medic-pacient-familie şi o complianţă ridicată a acestora din urmă la tratament. Foarte importantă este şi evaluarea corectă a calităţii vieţii copilului cu astm. Studiul de faţă şi-a propus verificarea corelaţiei între nivelul de control al astmului şi nivelul de inflamaţie eozinofilică de la nivelul căilor aeriene la copiii aflaţi în tratament cu corticosteroizi inhalatorii (CSI). Material şi metodă. Am evaluat un număr de 24 pacienţi care s-au prezentat la compartimentul de primiri urgenţe al spitalului IOMC „Alfred Rusescu“ Bucureşti în cursul a zece săptămâni din anotimpul rece. Evaluarea a constat în efectuarea scorului Asthma Control Test (ACT), măsurarea fracţiei de Oxid Nitric din aerul expirat (FeNO) şi probe funcţionale respiratorii. Rezultate şi discuţii. Valoarea scorului ACT în funcţie de măsurarea FENO arată o corelaţie liniară şi negativă cu r = -0.6286 (p < 0,01). Concluzii. Măsurarea FeNO este o metodă simplă, rapidă şi neinvazivă. Valoarea FeNO este corelată cu scorul ACT, în mod liniar şi negativ. Crearea unor algoritmi simpli ar putea îmbunătăţi controlul şi monitorizarea evoluţiei şi ar permite personalizarea terapiei la copilul cu astm.
Indicele intimă medie carotidian la copiii obezi născuţi cu greutate mică pentru vârsta gestaţională versus cei născuţi cu greutate normală pentru vârsta gestaţională
Authors:   Spitalul Clinic de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Stroescu Ramona ,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România, Micle Ioana ,   Spitalul Clinic de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Bizerea Teofana ,   Spitalul Clinic de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România, Mărăzan Monica ,   Spitalul Clinic de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Puiu Maria ,   Spitalul Clinic de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România, Doroş Gabriela ,   Spitalul Clinic de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România, Mărginean Otilia ,   Spitalul Clinic de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România
Published: July 2022

Indicele intimǎ medie carotidian (IMc) este un cunoscut marker subclinic pentru aterosclerozǎ. Fenomenul de recuperare nutriţionalǎ la copiii nǎscuţi mici pentru vârsta gestaţionalǎ (SGA) a fost asociat cu obezitate precoce şi cu riscul dezvoltǎrii sindromului metabolic. Scop. De a determina dacǎ existǎ o asociere între SGA şi IMc; de a stabili valori prag ale IMc la copiii obezi. Material şi metodǎ. Studiul prospectiv a fot derulat pe o perioadǎ de un an (iulie 2012 – iunie 2013). Au fost analizaţi 122 de pacienţi cu obezitate, 96 de pacienţi nǎscuţi cu greutate normalǎ pentru naştere (AGA) şi 26 de pacienţi nǎscuţi cu greutate micǎ pentru naştere (SGA). Ambele loturi au fost omogene din punct de vedere al vârstei, sexului şi indicelui de masǎ corporalǎ (IMC). Folosind curba ROC au fost stabilite valori prag pentru ambele grupe. IMc a fost semnificativ mai crescut la lotul SGA (p = 0,0035). Valoarea prag de 0,049 cm pentru IMc a fost obţinutǎ la ambele loturi, cumulat, cu o specificitate şi sensibilitate crescutǎ. Concluzii. Copiii nǎscuţi SGA se asociazǎ cu risc aterosclerotic. IMc este un cunoscut marker subclinic pentru aterosclerozǎ, fiind o metodǎ ieftinǎ şi noninvazivǎ. Studii populaţionale extinse sunt necesare în vederea stabilirii unor valori prag în ceea ce priveşte IMc.
Apneea în somn: manifestare sau cauză a convulsiilor la copil? Prezentare de caz
Authors:   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România, Marcovici Tamara-Marcela ,   Spitalul de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Belei Oana ,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România,   Spitalul de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Chiru Daniela ,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România,   Spitalul de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Stroescu Ramona ,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România,   Spitalul de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Brad Giorgiana ,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România,   Spitalul de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Olariu Laura ,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România,   Spitalul de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România, Mărginean Otilia ,   Universitatea de Medicină şi Farmacie „Victor Babeş“, Timişoara, România,   Spitalul de Urgenţă pentru Copii „Louis Ţurcanu“, Timişoara, România
Published: July 2022

Introducere. Apneea în somn (SA) la copil este subdiagnosticată. Compromiterea dezvoltării somatice şi alterarea calităţii vieţii sunt frecvent prezente. Apneea centrală în somn (CSA) poate reprezenta cauza episoadelor convulsive morfeice sau poate fi consecinţa acestora. Polisomnografi a reprezintă gold-standardul evaluării obiective a SA. Material şi metodă. Prezentăm un băiat în vârstă de 7 ani internat în septembrie 2013 pentru episoade de sufocare survenite în timpul somnului. Evaluarea s-a realizat prin anamneză, examen clinic, investigaţii paraclinice (funcţionale, imagistice, biologice) şi consulturi interdisciplinare. Rezultate. Repetate infecţii de căi respiratorii şi istoric de aproximativ 20 de zile al episoadelor de sufocare s-au stabilit anamnestic. Au fost diagnosticate următoarele: hipotrofie ponderală; rinită cronică; hipertrofie amigdaliană; disfuncţie ventilatorie obstructivă; apnee în somn formă mixtă predominant centrală; status atopic; sindrom convulsiv. Explorările imagistice au relevat aspecte normale. Tratamentul complex igieno-dietetic şi medicamentos a condus la dispariţia tulburărilor respiratorii în somn, cu normalizarea parametrilor spirometrici şi a statusului nutriţional. Concluzii. Studiul poligrafic al somnului a identificat apneea în somn, precizând predominanţa componentei centrale şi facilitând diagnosticul etiologic. Managementul interdisciplinar a condus la evoluţia favorabilă a cazului.
Liposarcom osos primar la copil
Authors:   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Miron Ingrid ,   Spitalul Clinic de Urgenţă pentru Copii „Sfânta Maria“, Iaşi, România, Aprodu Gabriel ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România,   Spitalul Clinic de Urgenţă pentru Copii „Sfânta Maria“, Iaşi, România, Mihăilă Doina ,   Spitalul Clinic de Urgenţă pentru Copii „Sfânta Maria“, Iaşi, România, Plamădeală Petru ,   Spitalul Clinic de Urgenţă pentru Copii „Sfânta Maria“, Iaşi, România, Miron Oana Tatiana ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Ciubară Anamaria ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România,   Spitalul Clinic de Psihiatrie „Socola“, Iaşi, România, Miron Lucian ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România,   Institutul Regional de Oncologie, Iaşi, România, Burlea Marin ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România,   Spitalul Clinic de Urgenţă pentru Copii „Sfânta Maria“, Iaşi, România, Moisă Ştefana Maria ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România,   Spitalul Clinic de Urgenţă pentru Copii „Sfânta Maria“, Iaşi, România, Lucaci Laurenţiu ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România,   Institutul de Boli Cardiovasculare „Prof. Dr. George Georgescu“, Iaşi, România
Published: July 2022

Introducere. Deşi liposarcomul de ţesuturi moi este o tumoră frecventă, liposarcomul primar osos este foarte rar, fiind localizat în special în oasele lungi. Material şi metodă. Prezentăm cazul unei paciente în vârstă de 14 ani, spitalizată în Spitalul Clinic de Urgenţă pentru Copii „Sfânta Maria“ din Iaşi pentru durere, impotenţă funcţională şi tumefacţia bratului drept, simptome ce au debutat cu 24 de ore anterior internării, ca urmare a unui traumatism prin cădere al braţului drept. Radiografia osoasă a evidenţiat o masă tumorală în porţiunea proximală a humerusului, asociată cu o fractură patologică. Rezultate. S-a realizat o biopsie la nivelul tumorii, iar analiza anatomopatologică (histologică şi imunochimică) a documentat proliferare liposarcomatoasă malignă. Concluzie. Diagnosticul anatomopatologic final, corelat cu examenul fizic, care a exclus posibilitatea unei metastaze osoase liposarcomatoase, a fost aceea de liposarcom primar osos. Particularitatea cazului: tumoră foarte rară, cu prezentare iniţială de fractură osoasă patologică. În stabilirea diagnosticului de liposarcom osos primar, trebuie exclusă posibilitatea unei metastaze de la un liposarcom cu localizare iniţială extraosoasă, ca şi pe cea a unui alt tip de tumoră osoasă primară. Prognosticul pare a fi mai favorabil decât cel al osteosarcomului, dar liposarcomul prezintă o rată mai mare de recurenţe locale şi diseminări sistemice.
Accident vascular cerebral ischemic la un copil cu cardiopatie congenitală cianogenă complexă
Authors:   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Rugină Aniela Luminiţa , Ştreangă Violeta ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Nistor Nicolai ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Buhuşi Gabriela ,   Spitalul de Urgenţă pentru Copii „Sf. Maria“, Iaşi, România, Filipescu Ramona ,   Spitalul de Urgenţă pentru Copii „Sf. Maria“, Iaşi, România, Iordache Constantin ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România, Ciomaga Irina-Mihaela ,   Universitatea de Medicină şi Farmacie „Gr. T. Popa“, Iaşi, România
Published: July 2022

Accidentul vascular cerebral (AVC) este rar la copil comparativ cu adultul. Cauzele cele mai comune de AVC la copil sunt cardiopatiile emboligene pentru infarctul cerebral şi malformaţiile arteriovenoase pentru hemoragiile cerebrale, dar un număr de cazuri rămân idiopatice, fără a li se putea afi rma etiologia precisă. Autorii prezintă cazul unui copil diagnosticat în perioada de sugar cu malformaţie congenitală de cord cianogenă complexă, dar neoperată, internat cu semne clinice şi radiologice de pneumonie, care a evoluat favorabil sub tratament antibiotic şi simptomatic. În timpul perioadei rezolutive a pneumoniei, copilul devine brusc somnolent, prezentând hemiplegie dreaptă cu absenţa reflexelor de aceeaşi parte. Examenul clinic corelat cu CT cranio-cerebral au stabilit diagnosticul de AVC ischemic sylvian bilateral. Evoluţia a fost favorabilă sub tratament conservator (antiagregante plachetare, fizioterapie), persistând însă hemiplegia dreaptă.
Current trends in feeding and caring for premature and low birth weight infants
Authors:   “Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, Florescu Laura , Temneanu Oana ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania, Mindru Dana ,   “Gr. T. Popa“ University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

Low weight at birth is an important indicator of infant health due to the tight relationship between birth weight and infant mortality and morbidity. The diminishing of the mortality and morbidity rate requires information on the growth characteristics and caring requirements for this category of children. Regardless of the category they are in – prematures, Small for Gestational Age, delay in intrauterine growth – these children, due to their low weight at birth present a high risk to develop malnutrition, a reason why there should be known the energy requirements and the optimum nutrition principles, specific to them. Ensuring an early most favourable diet is the essential element in their care assistance.
Correlation between FeNO value and asthma severity
Authors:   ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania, Buzoianu Eugenia ,   ”Victor Gomoiu” Children Clinical Hospital, Bucharest, Romania, Moiceanu Mariana ,   ”Victor Gomoiu” Children Clinical Hospital, Bucharest, Romania, Plesca Doina Anca ,   ”Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania,   ”Victor Gomoiu” Children Clinical Hospital, Bucharest, Romania
Published: July 2022

Objective. The purpose of this study is to assess the correlation between the FeNO (fractional exhaled nitric oxide) value and asthma severity. Material and method. A prospective study including 48 children aged 5 to 18 years, who have been diagnosed with asthma in „Victor Gomoiu” Children Clinical Hospital between May 2012 – November 2013, has been initiated. In the first stage of the study both the diagnosis and the degree of severity of asthma, using GINA 2008 guideline criteria, have been established, and the FeNO value has been measured before beginning any controller therapy. For the persistent asthma forms the controller therapy has been initiated, adapted to provide the controlled asthma status. In the next stage, after GINA 2014 guideline was published, a second classification of asthma, based on the degree of severity, has been performed, by taking into account the treatment step necessary to maintain the controlled asthma status, according to this new guide. Finally the correlation between FeNO value and the degree of asthma severity has been assessed, using first the asthma classification from GINA 2008 guideline and then the asthma classification from GINA 2014 guideline. Results. Among those 48 children included in the study 29 had normal FeNO value and 19 elevated FeNO value. According to GINA 2008 guideline criteria they have been included in the following severity asthma forms: 6 patients intermittent asthma, 27 patients mild persistent asthma, 14 patients moderate persistent asthma and 1 patient severe persistent asthma. According to GINA 2014 guideline criteria 25 patients have been labeled as mild asthma, 22 as moderate asthma and 1 as severe asthma. The statistic assessment of the correlation between asthma severity form according to GINA 2008 guideline and FeNO value provided a value of p = 0,278 and for the correlation between FeNO value and asthma severity form according to GINA 2014 guideline provided a value of p = 0,0468. Conclusion. FeNO value is not correlated with asthma severity as resulted from GINA 2008 guideline classification, but is correlated with asthma severity as resulted from GINA 2014 guideline classification.
Clinical-epidemiological considerations regarding primary peptic ulcer in children – 5 years retrospective study
Authors:   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Diaconescu Smaranda , Ignat Ancuta ,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Gimiga Nicoleta ,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Olaru Claudia ,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Paduraru Gabriela ,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Lacatus Alexandru ,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Aprodu Sandu Gabriel ,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania, Burlea Marin ,   “Gr. T. Popa” University of Medicine and Pharmacy, Iasi, Romania
Published: July 2022

Primary peptic ulcer still remains highly quoted in children from developing countries, the infection with H. pylori having a high incidence among this cases. Between 2007 and 2012 a retrospective study was performed, involving 84 children who were hospitalized in our clinic, ulcer disease being the main diagnosis. The study’s inclusion criteria were suggestive clinical symptoms and positive endoscopy. The studied group consisted by 79 children with primary ulcer and 5 with secondary ulcer. Reporting data for 1,400,000 children population in North – Eastern Romania an incidence of 5.64/100.000 of primitive ulcer disease has been found, the frequency being 2.58% compared with the overall 3052 upper digestive endoscopies done in the years mentioned above. Male to female ratio was 1.46:1. 77.41% of the patients originated in urban areas. The onset was by functional digestive syndrome in 70,89% of the cases or by complications in 29.11% of the cases. By upper digestive endoscopy 62 duodenal ulcers (DU) and 10 gastric ulcers (GU) were identified. Perforation allowed intraoperative diagnosis of ulcerative lesions in 7 children. 70.89% were H. pylori infection – related ulcers. The contributing factors for developing this condition were improper diet (63.16%), smoking (57.89), alcohol consumption (15.78), psychological stress (27.27%). We obtained a significant correlation between the high number of a family members, (r = 0.63%; p = 0.002), the low socio-economical status (r = 0.87, p = 0.0003) and H. pylori infection. We used the standard triple therapy on 73.33% of the patients, the quadruple therapy, based on bismuth on 16.66% of the children, and the sequential therapy in 10% of the cases. The global eradication rate was 66.66% therefore we considered this as being an indirect proof for the high clarithromycin resistance in children from our region.
La importancia de los alimentos silvestres para la seguridad alimentaria en tiempos de COVID-19
Authors: Diaz Puente José María , Suarez Valenzuela Diego
Published: July 2022

Se analiza la seguridad alimentaria en el contexto de la COVID-19, a partir de los aportes de (Asprilla-Perea y Díaz Puente, 2019; Asprilla-Perea et al., 2020, 2021). Al respecto, el consumo de alimentos silvestres se presenta como una opción para el logro de la seguridad alimentaria, sobre todo en áreas de bosque tropical.
Sobre el cultivo de tilapia: relación entre enfermedades y calidad del agua
Authors: Paredes-Trujillo Amelia , Mendoza-Carranza Manuel
Published: July 2022

La tilapia, originaria de África, ha sido introducida en cientos de países con fines de cultivo, generando un importante mercado, cubriendo necesidades alimentarias de amplios sectores de la población. La introducción de la tilapia ha traído problemas de invasiones en prácticamente todos los ambientes acuáticos tropicales de América y otros continentes, afectando la biodiversidad. Su cultivo ha generado necesidad de agua en altas cantidades, por lo que frecuentemente se emplean aguas poco aptas y sin tratamiento previo; además el agua que se emplea en los cultivos comúnmente es regresada al medio sin ningún tratamiento agudizando el problema. La mala calidad del agua produce estrés en los peces, volviéndolos susceptibles a enfermedades parasitarias, produciendo bajos rendimientos y mortalidad. Otro problema que se enfrenta respecto a las enfermedades parasitarias es la falta de conocimiento de los productores para identificar, prevenir y contrarrestar estas enfermedades. La capacitación y seguimiento de las actividades acuícolas por parte de expertos, así como compartir experiencias es fundamental para reducir estos riesgos. Existen miles de artículos científicos y técnicos que abordan estas problemáticas, pero la mayoría no está al alcance de los productores que, al no estar preparados para el manejo y control de enfermedades, sufren pérdidas económicas y desmotivación. El objetivo de este ensayo es dar al lector una visión general de la relación entre el manejo, calidad del agua y diversas enfermedades parasitarias que atacan a la tilapia en las prácticas de cultivo.
La pandemia de COVID - 19, ¿Nueva realidad, viejas reglas?
Authors: Portillo Ríos Rixio Gerardo
Published: July 2022

La pandemia de COVID 19 ha trastocado todos los ámbitos de la vida social, y las formas de interacciones y relaciones sociales han tenido que plantearse desde la perspectiva de una nueva realidad. Por ello, el siguiente estudio pretende abordar la necesidad de la ética social como fundamento del desarrollo humano en el futuro de la post pandemia, a partir del aporte documental de las Ciencias Humanas y Sociales. La ética social puede facilitar la convivencia humana desde valores comunes, que emergen del bien y la responsabilidad compartida en el devenir histórico, de las generaciones que han sido marcadas por la vivencia y experiencia de una enfermedad global, y que necesariamente debe dejar lecciones para una realidad diferente. El estudio utiliza referencias bibliográficas de relevantes pensadores contemporáneos y el enriquecido patrimonio de la Doctrina Social de la Iglesia, así como las enseñanzas recientes del Papa Francisco, para dar respuesta a la interrogante sobre la nueva época tras la pandemia.
Políticas públicas y desarrollo agrario en el Perú: Un enfoque de planeamiento estratégico
Authors: Vargas Aspillaga Jesús Octavio David , Barrantes Mann German Alejandro Luís , Wong Altamirano Lear Scoth
Published: July 2022

El presente artículo de revisión tiene por objetivo analizar investigaciones previas sobre políticas públicas y desarrollo agroindustrial. Se empleará el método bibliográfico para analizar artículos científicos relacionados con eltema, y bajo el enfoque cualitativo. El alcance de la investigación es descriptivo y su diseño es no experimental,de corte transversal. Se recolectó la información en bases de datos como:Redalyc, Scopus, Ebsco y Alicia-Concytec.Posterior al análisis de la información se concluye que el sector agrícola tiene un adecuado potencial para garantizar la seguridad alimentaria y combatir la pobreza;resaltándose la importancia de mejorar el diseño de las políticas públicasen materia agroindustrial, las cuales a la fecha presentan deficiencias en su seguimiento y evaluación.
Garantías penitenciarias y el derecho a la rehabilitación social: Ecuador y Venezuela
Authors: Menéndez Macías Fabricio Grismaldo
Published: July 2022

El objetivo principal de este trabajo es determinar la incidencia de las garantías penitenciarias en el derecho a la rehabilitación social en Ecuador y Venezuela. Esta investigación es de tipo descriptiva-documental, con aplicación del método analítico. Las nuevas tendencias penitenciarias están orientadas al otorgamiento de mayores garantías para las personas privadas de libertad;ello se corresponde con el reconocimiento e implementación de derechos y principios fundamentales que permitan la construcción de sus proyectos de vida, para lo cual es necesario la existencia de instituciones, políticas y personal que faciliten y viabilicen una rehabilitación social efectiva.El caso ecuatoriano, se caracteriza por un conglomerado de normativas y políticas, que especifican todo un listado de derechos, obligaciones, acciones, programasy demás actividades administrativas y judiciales para la rehabilitación integral de las personas privadas de libertad, lo cual implica el desarrollo de las capacidades y cumplimiento de sus responsabilidades para ejercer sus derechos al momento de recuperar completamente su libertad. El Estado ecuatoriano es garantista de derechos, puesto que ampara formalmente los derechos de estas personas. El ordenamiento jurídico venezolano también dispone una concepción garantista de los derechos de las personas privadas de libertad, aunque con menos exhaustividad normativa si se compara con el ordenamiento jurídico ecuatoriano. La Constitución venezolana prevé una rehabilitación integral y progresiva de las personas privadas de libertad, que coadyuve a su transformación y reinserción en la sociedad.
TESS Observations of Kepler Systems with Transit Timing Variations
Authors: Jontof-Hutter Daniel , Dalba Paul A. , Livingston John H.
Published: July 2022

We identify targets in the Kepler field that may be characterized by transit timing variations and are detectable by the Transiting Exoplanet Survey Satellite (TESS). Despite the reduced signal-to-noise ratio of TESS transits compared to Kepler, we recover 48 transits from 13 systems in Sectors 14, 15, 26, 40 and 41. We find strong evidence of a nontransiting perturber orbiting Kepler-396 (KOI-2672) and explore two possible cases of a third planet in that system that could explain the measured transit times. We update the ephemerides and mass constraints where possible at KOI-70 (Kepler-20), KOI-82 (Kepler-102), KOI-94 (Kepler-89), KOI-137 (Kepler-18), KOI-244 (Kepler-25), KOI-245 (Kepler-37), KOI-282 (Kepler-130), KOI-377 (Kepler-9), KOI-620 (Kepler-51), KOI-806 (Kepler-30), KOI-1353 (Kepler-289), and KOI-1783 (Kepler-1662).
Predictions for Observable Atmospheres of Trappist-1 Planets from a Fully Coupled Atmosphere–Interior Evolution Model
Authors: Krissansen-Totton J. , Fortney J. J.
Published: July 2022

The Trappist-1 planets provide a unique opportunity to test the current understanding of rocky planet evolution. The James Webb Space Telescope is expected to characterize the atmospheres of these planets, potentially detecting CO2, CO, H2O, CH4, or abiotic O2 from water photodissociation and subsequent hydrogen escape. Here, we apply a coupled atmosphere–interior evolution model to the Trappist-1 planets to anticipate their modern atmospheres. This model, which has previously been validated for Earth and Venus, connects magma ocean crystallization to temperate geochemical cycling. Mantle convection, magmatic outgassing, atmospheric escape, crustal oxidation, a radiative-convective climate model, and deep volatile cycling are explicitly coupled to anticipate bulk atmospheres and planetary redox evolution over 8 Gyr. By adopting a Monte Carlo approach that samples a broad range of initial conditions and unknown parameters, we make some tentative predictions about current Trappist-1 atmospheres. We find that anoxic atmospheres are probable, but not guaranteed, for the outer planets; oxygen produced via hydrogen loss during the pre-main sequence is typically consumed by crustal sinks. In contrast, oxygen accumulation on the inner planets occurs in around half of all models runs. Complete atmospheric erosion is possible but not assured for the inner planets (occurs in 20%–50% of model runs), whereas the outer planets retain significant surface volatiles in virtually all model simulations. For all planets that retain substantial atmospheres, CO2-dominated or CO2–O2 atmospheres are expected; water vapor is unlikely to be a detectable atmospheric constituent in most cases. There are necessarily many caveats to these predictions, but the ways in which they misalign with upcoming observations will highlight gaps in terrestrial planet knowledge.
Geometric Assumptions in Hydrodynamic Modeling of Coronal and Flaring Loops
Authors: Reep Jeffrey W. , Ugarte-Urra Ignacio , Warren Harry P. , Barnes Will T.
Published: July 2022

In coronal loop modeling, it is commonly assumed that the loops are semicircular with a uniform cross-sectional area. However, observed loops are rarely semicircular, and extrapolations of the magnetic field show that the field strength decreases with height, implying that the cross-sectional area expands with height. We examine these two assumptions directly, to understand how they affect the hydrodynamic and radiative response of short, hot loops to strong, impulsive electron beam heating events. Both the magnitude and rate of area expansion impact the dynamics directly, and an expanding cross section significantly lengthens the time for a loop to cool and drain, increases upflow durations, and suppresses sound waves. The standard T ∼ n
2 relation for radiative cooling does not hold with expanding loops, which cool with relatively little draining. An increase in the eccentricity of loops, on the other hand, only increases the draining timescale, and is a minor effect in general. Spectral line intensities are also strongly impacted by the variation in the cross-sectional area because they depend on both the volume of the emitting region as well as the density and ionization state. With a larger expansion, the density is reduced, so the lines at all heights are relatively reduced in intensity, and because of the increase of cooling times, the hottest lines remain bright for significantly longer. Area expansion is critical to accurate modeling of the hydrodynamics and radiation, and observations are needed to constrain the magnitude, rate, and location of the expansion—or lack thereof.
The Strategy of Workforce Management Based on Risk Assessment of Manual Handling Work with Suitability of Work Environment in Makasar Industrial Area, Indonesia
Authors: K Basri , K Sarinah Basri
Published: July 2022

BACKGROUND: A good work environment suitability has a major impact on health and safety, and it encourages a more productive workforce. When it is incompatible with labor, it can lead to unintended impacts and various risks.

AIM: We aimed to investigate the strategy of workforce management based on risk assessment of manual handling work with suitability of work environment in Makasar industrial area, Indonesia.

METHODS: Twenty three workforce samples are selected from Makassar Industrial Area (KIMA), Indonesia. The risk of manual handling work is assessed based on the suitability of the work environment to the workforce’s response using Guttman scale, in which the answer YES = 1 means there is a risk, while the answer NO = 0 means there is no risk. However, the scales are the reproducibility coefficient ≥ 0.90 and scalability coefficient ≥0.60, and Guttman scale score is calculated from Tn = total answers of “YES” for the KPI in the scale. Meanwhile, the SWOT-4Q is used to analyze the strategy of industry supervisor samples.

RESULTS: For the workforce, eight of nine risk assessments do not show risk, and only “high vibration intensity in the workplace,” with a percentage of 78.26%, affects the excessive condition. The strategy used by the supervisors in quadrant I is in accordance with the strength of the risk assessment and has a great opportunity to reduce risk. The management maximally exploits the big opportunity of the manual handling work.

CONCLUSIONS: The results showed that most of the workforce did not experience the risk of manual handling work with the suitability of the work environment. In addition, industrial supervisors should implement a growth strategy because they can enlarge the industry by taking advantage of the advantages of manual handling work to maximize the exploitation of large manual handling work opportunities.
Does Exposure to Health-related Information and Peer Effects Affect the Nutritional Status of Adolescents in Urban and Rural Areas?
Authors: Wati Erna Kusuma , Dardjito Endo , Proverawati Atikah , Wahyurin Izka Sofiyya , Putri Widya Ayu Kurnia , Andini Katri , Hapsari Pramesthi Widya
Published: July 2022

BACKGROUND: The influence of health information exposure particularly from peer influences on the health and nutrition of adolescents and its effect on the nutritional status of female adolescents.

AIM: The purpose of this research is to acknowledge the health information exposure and peer influences on female adolescents in urban and rural areas.

METHODS: This study used a cross-sectional study design. The sample was 96 female adolescents with 44 from State Junior High School 1 Purwokerto representative of the urban area and 52 female adolescents from State Junior High School 1 Patikraja as representative from rural area. Exposure data and health information sources were collected using a questionnaire, peer influences measurement using Peer Influence Scale (PIS) questionnaire, and nutrition status measurement using Body Mass Index per age. The Statistics Test used in this study was Chi-square and Fisher Exact with 5% accuracy.

RESULTS: No significant association was found between health information exposure and peer influences with nutrition status in female adolescents (p = 0.29; 0.77 > 0.05) and there was also no significant difference in acceptance source and health nutrition information topic of female adolescents in urban and rural areas. However, there was a significant difference between peer influences in female adolescents in urban and rural areas (p = 0.00 < 0.05).

CONCLUSION: In both groups of female adolescents from urban and rural, there was comparable acceptance in their sources of information regarding health and nutrition. There was a significant difference in the effect of peer influences between female adolescents in urban and rural areas. However, peer influences does not have any effect on their nutrition status.
Multidrug-resistant Tuberculosis and COVID-19 Coinfection with Diabetes Mellitus in Medan, Indonesia: A Case Report
Authors: Sinaga Bintang Yinke Magdalena , Sinaga Joshua Princeman , Siagian Parluhutan
Published: July 2022

BACKGROUND: Coronavirus disease 2019 (COVID-19) has distracted the global health system due to significant morbidity and mortality. There are increasing mortality rates related to the existence of comorbidities. Due to immunologic conditions, other infectious diseases, such as multidrug-resistant tuberculosis (MDR-TB), might coinfect with COVID-19. We describe a case of MDR-TB with diabetes mellitus and critical COVID-19 patient with fatal outcome.

CASE REPORT: A 60-year-old man was admitted to our hospital with shortness of breath for 2 days. A history of recurrent shortness of breath has had developed for about 7 months. Room air oxygen saturation was at 66%. RT-PCR SARS-CoV-2 nasopharynx swab result was positive. The chest X-ray series result showed destroyed left lung with increasing infiltrate in the lower right lung. The patient was diagnosed with pulmonary MDR-TB based on GeneXpert and LPA (Line Probe Assay) test 6 months prior and also has had history of diabetes mellitus for 7 years. Then, the patient was diagnosed with COVID-19, pulmonary MDR-TB, and diabetes mellitus. MDR-TB regimen, anti-diabetic medication, and management of COVID-19 were carried out. On the 6th day, the patient’s condition worsened to the point, where he needed intubation. The patient eventually passed away.

CONCLUSION: The treatment outcome was highly related to the severity of COVID-19 symptoms and complications of comorbidities when patients are admitted to the hospital. The early screening and treatment of COVID-19 are important to prevent deteriorating clinical conditions caused by comorbidities.
Assessment of Knowledge and Lifestyle Pattern during COVID-19 Pandemic in Al-Qunfudhah’s Locality: In Saudi Arabia
Authors: Mohammed Manal , Gadah-Eldam Agba A. A. , Taha Zainab
Published: July 2022

The COVID-19 pandemic continues to pose significant challenges to nations. The Saudi Arabia government aimed to mitigate the spread of COVID-19 through different health strategies and policies that impact the population's health and lifestyle. This study aimed to assess the knowledge and awareness of the adult Saudi Arabian people and residents on the Coronavirus pandemic and examine their association with dietary habits. A cross-sectional study was conducted in Al-Qunfudhah’s locality   - Kingdom of Saudi Arabia from 13 September to 15 October.  Data collection was performed using a direct interview using a questionnaire, which was divided, into four sections:  the first section was directed at the socio-demographic characteristics of the participants; the second was dedicated to assessing the individual's knowledge about COVID-19; the third section was designed to assess the lifestyle pattern of COVID-19.  Dietary intake was assessed by food frequency questionnaires (FFQ). According to the results of data analysis, 400 respondents were included in this study. Knowledge about COVID-19 was high (94 %) among the participants, primarily obtained from the traditional media platforms and social media (71.20%.).  91%   of the respondents have complied with regular usage of precautionary tools, (8%) sometimes, 56.5 % of the respondents experienced a change in food habit during the period of confinement. Food items which presented a higher consumption were:  fish on the top of  the groups  (83.25 %),   followed by anion and orange  (47%) for both , lemon drink   (42.75 %),  potatoes and garlic almost  achieved similar  percentages  (38.25% & 38.75)  respectively,  while milk and milk product came on the bottom of the list (37.75). Medium intake illustrated lettuce, green pepper and carrots were taken by nearly almost one-third of the participants 34% 34% &32%, respectively, followed by meat (31.75%).  Lower intake was   noticed for eggs (29.25%) and lentils (33.5%). Vegetables including pumpkin, broccoli and cauliflower represented low intake by half of the participants (50%) , physical activity and exposure to sunlight were practiced regularly during the lockdown, by (43%), (49.8 %.) respectively. These findings include the Saudis and residential population who have adopted healthier dietary behaviors during the COVID-19 confinement through a closer approach towards the Med Diet-style eating patterns.
The knowledge of eating habits and the practice of physical activity should guide the authorities and educational agencies to propose strategies that could encourage a balanced and healthy diet (MD) and physical activity practice.
Relationship between the Level of Amylinemia and Albuminuria Categories in Patients with Latent Autoimmune Diabetes in Adults
Authors: Tsaryk Iryna , Pashkovska Nataliia
Published: July 2022

BACKGROUND: β-cells of islets of Langerhans produce not only insulin but another hormone – amylin, whose role in the development and progression of chronic kidney disease (CKD) in patients with diabetes mellitus (DM) is not known for certain.

AIM: The aim of the study was to determine the relationship between amylinemia and albuminuria categories in patients with latent autoimmune diabetes in adults (LADA) and CKD.

METHODS: 89 patients with DM and CKD were examined, as well as 15 representatives of the control group. The patients were divided into three groups by the types of DM: 36 patients with LADA, 25 patients with classical type 1 diabetes mellitus (T1D), and 28 patients with type 2 diabetes (T2D). Serum amylin levels were measured using the enzyme-linked immunosorbent assay (ELISA) method.

RESULTS: In the group of patients with LADA, the amylin content was 9.0 times higher than in control (p < 0.01) and 6.8 times higher compared to classical T1D (p < 0.01); at the same time, it was 17.3% lower than in T2D group (p < 0.05). In patients with T1D, the level of amylinemia did not change, whereas in T2D group it was 10.8 times significantly higher compared to the control and 8.3 times higher than in the group of patients with classical T1D. The highest indicator was registered in patients with LADA2 phenotype. The level of amylin was increasing in proportion to the categories of albuminuria. Positive correlations were found between the content of amylin and insulin, C-peptide, Homeostasis Model Assessment of Insulin Resistance (HOMA-IR) index and creatinine.

CONCLUSION: Serum amylin level significantly increases progrediently to the albuminuria categories in patients with LADA (especially in LADA2 phenotype) and T2D.
Patient Awareness of Additive Manufacturing in Dentistry – A Survey
Authors: Shopova Dobromira , Bakova Desislava , Semerdjieva Maria , Yaneva Antonia
Published: July 2022

Introduction: Additive manufacturing or 3D printing technology creates the object layer by layer. Its development in dentistry has been particularly rapid over the last ten years and covers more and more dental fields.
The aim of this article is to demonstrate the patient’s awareness of additive manufacturing and their opinion about the price and application of 3D printed products in dentistry.
Materials and methods: The survey was distributed to a total of 111 patients, of whom 49.5% were men and 50.5% were women. The majority of respondents have higher education. Their age varies from 34 to 76. Students do not participate in the survey. More than half of the respondents (55.5%) are retired.
Results and conclusion: Patients are mainly informed by dentists but consider themselves insufficiently informed. 3D printed versions are rarely offered, especially for temporary constructions. Patients rate the price as too high, but would not give up treatment only for that reason. They are hesitant in their choice for treatment with a classic or 3D printed technique.
The Future Perspectives of Redefining the Resection Margin Status in Different Cancers of Pancreas
Authors: Elshaer Ahmed , El-Sayed Tamer , Dasgupta Dowmitra
Published: July 2022

Background: The interest towards the assessment of circumferential resection margins(CRM) in pancreatic cancers has been evolving over last years. Whilst several studies investigated the influence of R1-resections on survival, not many studies evaluated the prognostic value of each resection margin. In this study, we examined the different resection margins to better understand their prognostic implications on overall survival.
Methods: This prospective study included a cohort of patients who had pancreaticoduodenectomy for cancer purposes at our institution from 2008 till 2013. Median follow-up was 6 years. Involved margins in R1-resections were further classified into anatomical margins (anterior, posterior and circumferential margins) and surgical margins (vascular/medial margins and transection margins). Overall survival was assessed for each specific resection margin.
Results: 134 patients were included with median age 66 years. R1-resection was done in 54% of patients(n=72/134). Median survival of R0-resection group was 6.3 years, compared to 1.9 years for R1-resection group(p-value 0.001). Vascular (surgical) margins had the lowest survival rate (1.7years) compared to anatomical margins (anterior, posterior and circumferential margins) with 3.6, 2.2 and 2.1 years respectively (p-value 0.02). On multivariate analysis; lymph node involvement and vascular resection were the only factors to correlate significantly with poor survival.
Conclusion: Whilst the new pathological protocols advised to perform rigorous margin assessment of CRM, the prognostic value of each resection margin is still unclear. This study  showed variation of survival across different resection margins with inferiority towards vascular (surgical) margins. This supported the need of redefining R1-margins in the future pathological classifications according to their different prognostic impacts.