bluuebunny/crossref_metadata_2025 huggingface dataset:
PERENCANAAN DESAIN TRANSPORT HUB PADA KAWASAN BERORIENTASI TRANSIT
Authors: H Ulinata
Published: October 2019

Jakarta Special Capital Region is surrounded by a lot of infrastructures to support its citizen, unfortunately it is not enough to cope with the citizen’s growth. The scarcity of infrastructures are easily seen in a lot of sectors, including transportation sector where the numbers of mass transportation systems are not equal with the population numbers, the widening road numbers which also lack in comparison with the growth of vehicles, etc. These kind of problems make Jakarta Citizens preferring to use personal transportation rather than public transportation, which causing more serious problems such as the increasing in transportation costs, reducing the mobility of its citizens, and decreasing in population quality of life because of heavy traffic jam that happens on daily basis. To solve these problems we need to create a development concept that can comply with the mobility of the people and oriented in mass transportation which is called Transit Oriented Development (TOD).The reason why Dukuh Atas were chosen is because Dukuh Atas located in the heart of Jakarta City and also surrounded by business districts, it also becoming a central hub where many public transportations route are connected, such as Airport Train Railink, KRL Commuter Jabodetabek, Transjakarta, LRT, MRT.One strategic spot that will be developed as a transportation hub is located in Jl. Kendal, right at the front of KRL Sudirman station. The design of transportation hub as a Dukuh Atas TOD will be considering eco friendly concept, hopefully it will create a city development that can increasing the quality of the life of its citizen.
PENINGKATAN KREATIVITAS GURU MELALUI PENGEMBANGAN SUPERVISI KEPALA SEKOLAH DAN IKLIM ORGANISASI
Authors: Ghifar Riyadhel , Yusuf Adi E , Sumardi Sumardi , Wulandari Farida
Published: October 2019

Penelitian  ini  bertujuan  menemukan   upaya-upaya   meningkatkan   kreativitas   guru  dan gambaran empiris studi tentang hubungan antara supervisi kepala sekolah dan iklim organisasi sekolah dengan kreativitas guru. Metode penelitian yang digunakan dalam penelitian ini adalah metode survei. Metode  survei  dengan  pendekatan  korelasional  dilakukan  terhadap  sampel  dari  suatu  populasi, kemudian menganalisa sampel, dan hasil analisa sampel diberlakukan untuk populasi. Populasi dalam penelitian ini adalah seluruh Guru PNS di SDN Se-Gugus 3 wilayah kecamatan Pancoran Mas Kota Depok Provinsi Jawa Barat yang berjumlah 138 orang dari 8 sekolah. Sampel diambil  dengan teknik proporsional random sampling, dan dengan rumus Slovin didapat jumlah sampel 103 orang. Penelitian ini menghasilkan kesimpulan sebagai berikut: 1) Terdapat hubungan positif dan signifikan antara Supervisi Kepala Sekolah dengan Kreativitas (ry1 = 0,630, α=0,01); 2) Terdapat hubungan positif, dan kuat, dan signifikan antara Iklim Organisasi dengan Kreativitas (ry2 = 0,730, α=0,01); 3) Terdapat hubungan positif yang sangat kuat, dan signifikan antara Supervisi Kepala Sekolah, dan Iklim Organisasi secara bersama-sama dengan Kreativitas (ry12 = 0,920, α=0,01). Kata Kunci : Supervisi Kepala Sekolah, Iklim Organisasi, Kreativitas
PENINGKATAN PRODUKTIVITAS KERJA DOSEN MELALUI PENGEMBANGAN EFEKTIVITAS SISTEM INFORMASI MANAJEMEN DAN BUDAYA ORGANISASI
Authors: Purwanti Annisa Restu , Hidayat Nandang , Sutisna Entis
Published: October 2019

Penelitian ini bertujuan untuk mengetahui bagaimana produktivitas kerja dosen dapat ditingkatkan melalui efektivitas sistem informasi manajemen dan budaya organisasi. Populasi yang diambil untuk penelitian ini adalah dosen di Universitas Muhammadiyah Sukabumi dengan status Dosen tetap yang berjumlah 134 dosen dengan sampel berjumlah 101 dosen. Pengumpulan data untuk setiap variabel penelitian menggunakan kuesioner. Teknik analisis data menggunakan analisis deskriptif, korelasi, regresi parsial dan ganda. Pengujian hipotesis dilakukan pada taraf signifikansi 0,05. Hasil penelitian menunjukkan bahwa terdapat hubungan positif yang signifikan antara efektivitas sistem informasi manajemen dengan produktivitas kerja dosen (ry1=0,342), terdapat hubungan positif yang sangat signifikan antara budaya organisasi dengan produktivitas kerja dosen (ry2=0,327), dan terdapat hubungan positif yang sangat signifikan antara efektivitas sistem informasi manajemen dan budaya organisasi secara bersama-sama dengan produktivitas kerja dosen (ry2=0,327). Dengan demikian dapat disimpulkan bahwa produktivitas kerja dosen dapat ditingkatkan melalui efektivitas sistem informasi manajemen dan budaya organisasi baik secara parsial maupun bersama-sama. Kata kunci: efektivitas sistem informasi manajemen, budaya organisasi, dan produktivitas kerja
Short-Term Deformability of Three-Dimensional Printable EVA-Modified Cementitious Mortars
Authors: Yeon Jaeheum
Published: October 2019

This study experimentally examined the deformability of cementitious mortars modified with ethylene-vinyl acetate (EVA) for use in extrusion-based additive construction. The research was based on the author’s previous study of the properties of fresh EVA-modified cementitious mixtures for use in additive construction via extrusion. The particular focus was on these mortars’ short-term deformation factors, including the modulus of elasticity, drying shrinkage, and thermal expansion. The experimental results indicate that as the EVA/cement ratio was increased, the compressive strength and elastic modulus tended to decrease but the maximum compressive strain increased. At 28 days, the drying shrinkage tended to increase as the EVA/cement ratio was increased. The coefficient of thermal expansion was also found to increase as the EVA/cement ratio was increased. A very high correlation was found between these three deformation factors and the EVA/cement ratio. Given these results, it was determined that the addition of EVA powder to EVA-modified cementitious mortars used in extrusion-based additive construction could adversely affect their short-term deformation factors. However, increasing the EVA/cement ratio resulted in a decrease in the modulus of elasticity, thereby reducing the level of stress caused by drying shrinkage and thermal expansion. This effect will eventually lead to improvements in the degree of extensibility, thereby offsetting the negative impacts. However, it is still desirable to minimize the EVA/cement ratio to the extent that adequate properties for the fresh material can be obtained.
Thermodynamic Analysis of Partitioned Combined Cycle using Simple Gases
Authors: Taimoor Aqeel Ahmad , Siddiqui Muhammad Ehtisham , Abdel Aziz Salem S.
Published: October 2019

In combined cycle gas turbines, most of the energy loss is usually due to the high temperature of the exhaust gases. Different heat recuperation methods are used. In this study, a novel direct method for heat recovery is investigated. Confidence in the results is established by accounting for all the losses and simulation errors while comparing with the conventional cycle. Aspen HYSYS and MATLAB are the simulation tools used. The General Electric (GE) 9HA.02 combined cycle is taken as a base case. Five gases, air, argon, hydrogen, nitrogen, and carbon dioxide, are studied with the proposed modification. The efficiency maximization function is updated and the pressure and temperature ratios of individual Brayton and Rankine cycles are discussed. The combustor/heat exchanger is modified and simulated according to the known principles of heat and momentum transfer. The whole simulation algorithm is provided. Equation of state (EOS-PR) is used to calculate the properties at every discretized step (for H2, critical properties are modified/HYSYS inbuilt feature). Different gases are analyzed according to their property profiles over the whole cycle. The effect of fluid properties on efficiency is discussed as a guideline for any tailored fluid.
Entropy Distribution in a Quantum Informational Circuit of Tunable Szilard Engines
Authors: Diazdelacruz Jose
Published: October 2019

This paper explores the possibility of extending the existing model of a single-particle Quantum Szilard Engine to take advantage of some features of quantum information for driving typical mechanical systems. It focuses on devices that output mechanical work, extracting energy from a single thermal reservoir at the cost of increasing the entropy of a qubit; the reverse process is also considered. In this alternative, several engines may share the information carried by the same qubit, although its interception will prove completely worthless for any illegitimate user. To this end, multi-partite quantum entanglement is employed. Besides, some changes in the cycle of the standard single-particle Quantum Szilard Engine are described, which lend more flexibility to meeting additional requirements in typical mechanical systems. The modifications allow having qubit input and output states of adjustable entropy. This feature enables the possibility of chaining the qubit between engines so that its output state from one can be used as an input state for another. Finally, another tweak is presented that allows for tuning the average output force of the engine.
When the Bough Breaks: How Do Local Authorities in the UK Assess Risk and Prepare a Response to Ash Dieback?
Authors: Ambrose-Oji Bianca , Stokes Jon , Jones Glyn D.
Published: October 2019

Ash dieback Hymenoscyphus fraxineus (T. Kowalski), is an alien fungal disease probably introduced to Europe from Asia that currently presents a significant threat to native ash (Fraxinus L. spp.). In the United Kingdom a large proportion of ash trees are found outside of woodlands. This means that a wide diversity of land owners and managers are stakeholders in the response to ash dieback. Local authorities (local government units) hold responsibility for managing ash trees along the highways and other public sites, with a focus on maintaining public health and safety. Developing local action plans (LAPs) for ash dieback is promoted by the government as way for local authorities to plan an effective strategic response at a landscape scale. However, risk assessment frameworks and the knowledge about ash dieback that is needed for quality decision-making at this level is still lacking. The scientific uncertainty around ash dieback progression, mortality rates, and the hazards presented by the trees at different stages of infection present knowledge problems. The research aims to (i) develop and evaluate an approach to addressing ash dieback suited to local authorities across the United Kingdom, and (ii) address the research gaps surrounding the local authority approaches to risk assessment and overcoming “knowledge problems.” Our hypothesis is that action research can be used to develop an effective risk assessment framework and knowledge tools that can improve decision-making. Our research questions in support of these objectives are: (i) How do local authorities perceive, assess, and plan for risks? (ii) What information and knowledge do local authorities need to assess and manage the specific risks of ash dieback? Lastly, (iii) what processes drive the local authorities toward preparing and implementing LAPs? Data collection occurred between 2015–2019 and included: deliberative co-production and validation workshops, two survey questionnaires, and evaluative semi-structured interviews (SSIs). Local authorities were shown to assess risk and proportionality of response to ash dieback through processes of deliberative social learning mixing opinion, scientific and practice-based knowledge to reach a consensus over the methods and knowledge that would be used in decision-making. Placing ash dieback on corporate risk registers that cut across the multiple departments dealing with the problem facilitated political approval, action planning, and budget allocation. Generating locally specific knowledge and finding the resources and personnel to drive forward strategic planning and implementation were key to landscape scale responses and ratifying LAPs. Collaborative action research working on ways of assessing, learning, and responding to tree pests and diseases offer an important approach to problem-solving and developing responses at the landscape scale.
The Origin of Dissolved Sulphate in the Thermal Waters of Budapest Inferred from Stable S and O Isotopes
Authors: Fórizs István , Szabó Viktória , Deák József , Hałas Stanisław , Pelc Andrzej , Trembaczowski Andrzej , Lorberer Árpád
Published: October 2019

The thermal waters produced by wells and springs from the Buda Thermal Karst in Budapest and its surroundings are rich in dissolved sulphate. Radiocarbon ages indicate that waters of T >45 ℃ were infiltrated during the Ice Age (more than 11 thousand years ago), on the higher elevations of the Buda-Pilis Hills, whereas waters of lower temperatures were infiltrated during the Holocene. For the origin of dissolved sulphate, two hypotheses can be set up: (1) the dissolved sulphate originates from the oxidation of the sulphide (pyrite) of Oligocene Clay Formation; (2) it is the dissolution product of the sulphate minerals (gypsum and anhydrite) of older carbonaceous rocks (limestone and dolomite). The isotopically stable sulphur composition of the dissolved sulphate in the thermal water (δ34S = 9.7‰ to 17.7‰) indicates its marine origin, so likely it dissolved from the older Permian evaporites.
Moderating Effect of Dynamic Environment in the Relationship between Guanxi, Trust, and Repurchase Intention of Agricultural Materials
Authors: Li Lan , Li Gang , Feng Xiaoling , Liu Zhigao , Tsai Fu-Sheng
Published: October 2019

Repurchasing intention of agricultural materials is a key to a sustainable food business system. The novel contribution of this study is that we go beyond technical aspect and look into human capital dynamics in a general context, by examining how different dimensions of ‘guanxi’ (i.e., personal relations and instrumentality) between farmers and agricultural retailers affect trust between the two and, in turn, repeated purchase intention of agricultural materials by farmers in China. To further generate implications for food system as a whole, we also examined how dynamic environment moderates the effects mentioned above. Adopting survey method and multivariate analyses, this study tests the hypotheses with a collected data set of 578 farmers from representative rural areas of China. The results show that guanxi between farmers and agricultural retailers has a positive effect on trust between them and on repeated purchase intentions of farmers. While instrumentality has a negative effect on trust between them and on repeated purchase intentions of farmers. The trust between farmers and agricultural retailers promotes farmers’ repeated purchase intentions. The intensity of competition negatively moderates the positive relation between trust and repeated purchases. Demand uncertainty does not moderate the positive effect of trust on repeated purchases. The results and discussion shed light on agricultural food system sustainability from a dynamic environment embedded business relationship perspective.
Senior Co-Housing in the Netherlands: Benefits and Drawbacks for Its Residents
Authors: Rusinovic Katja , Bochove Marianne van , Sande Jolien van de
Published: October 2019

Senior co-housing communities offer an in-between solution for older people who do not want to live in an institutional setting but prefer the company of their age peers. Residents of co-housing communities live in their own apartments but undertake activities together and support one another. This paper adds to the literature by scrutinizing the benefits and drawbacks of senior co-housing, with special focus on the forms and limits of social support and the implications for the experience of loneliness. Qualitative fieldwork was conducted in eight co-housing communities in the Netherlands, consisting of document analysis, interviews, focus groups, and observations. The research shows that co-housing communities offer social contacts, social control, and instrumental and emotional support. Residents set boundaries regarding the frequency and intensity of support. The provided support partly relieves residents’ adult children from caregiving duties but does not substitute formal and informal care. Due to their access to contacts and support, few residents experience social loneliness. Co-housing communities can potentially also alleviate emotional loneliness, but currently, this happens to a limited degree. The paper concludes with practical recommendations for enhancing the benefits and reducing the drawbacks of senior co-housing.
Comparison of Main Approaches for Extracting Behavior Features from Crowd Flow Analysis
Authors: Ebrahimpour Zeinab , Wan Wanggen , Cervantes Ofelia , Luo Tianhang , Ullah Hidayat
Published: October 2019

Extracting features from crowd flow analysis has become an important research challenge due to its social cost and the impact of inadequate planning of high-quality services and security monitoring on the lives of citizens. This paper descriptively reviews and compares existing crowd analysis approaches based on different data sources. This survey provides the fundamentals of crowd analysis and considers three main approaches: crowd video analysis, crowd spatio-temporal analysis, and crowd social media analysis. The key research contributions in each approach are presented, and the most significant techniques and algorithms used to improve the precision of results that could be integrated into solutions to enhance the quality of services in a smart city are analyzed.
Targeting Inflammation by Flavonoids: Novel Therapeutic Strategy for Metabolic Disorders
Authors: Farzaei Mohammad Hosein , Singh Amit Kumar , Kumar Ramesh , Croley Courtney R. , Pandey Abhay K. , Coy-Barrera Ericsson , Kumar Patra Jayanta , Das Gitishree , Kerry Rout George , Annunziata Giuseppe , Tenore Gian Carlo , Khan Haroon , Micucci Matteo , Budriesi Roberta , Momtaz Saeideh , Nabavi Seyed Mohammad , Bishayee Anupam
Published: October 2019

A balanced metabolic profile is essential for normal human physiological activities. Disproportions in nutrition give rise to imbalances in metabolism that are associated with aberrant immune function and an elevated risk for inflammatory-associated disorders. Inflammation is a complex process, and numerous mediators affect inflammation-mediated disorders. The available clinical modalities do not effectively address the underlying diseases but rather relieve the symptoms. Therefore, novel targeted agents have the potential to normalize the metabolic system and, thus, provide meaningful therapy to the underlying disorder. In this connection, polyphenols, the well-known and extensively studied phytochemical moieties, were evaluated for their effective role in the restoration of metabolism via various mechanistic signaling pathways. The various flavonoids that we observed in this comprehensive review interfere with the metabolic events that induce inflammation. The mechanisms via which the polyphenols, in particular flavonoids, act provide a promising treatment option for inflammatory disorders. However, detailed clinical studies of such molecules are required to decide their clinical fate.
Antidiabetic and Cosmeceutical Potential of Common Barbery (Berberis vulgaris L.) Root Bark Extracts Obtained by Optimization of ‘Green’ Ultrasound-Assisted Extraction
Authors: Dulić Marina , Ciganović Petar , Vujić Lovorka , Zovko Končić Marijana
Published: October 2019

Berberis vulgaris is rich in berberine, an isoquinoline alkaloid, with antidiabetic activity, often used topically for skin-related problems. The aim of this work was to develop a “green” method for berberine extraction using mixtures of water with glycerol, a non-toxic, environmentally-friendly solvent. Response surface methodology based on Box–Behnken design was used to optimize the experimental conditions for ultrasound-assisted extraction of berberine and anti-radical components from B. vulgaris root bark. The independent variables were temperature (X1), glycerol concentration (X2), and ultrasound power (X3), while the responses were berberine concentration and DPPH radical scavenging activity of the extracts (RSA IC50). The response values of the extracts prepared at optimum conditions were (response, X1, X2, X3): berberine yield (145.5 μg/mL; 80 °C, 50%, 144 W) and RSA IC50 (58.88 μL/mL; 80 °C, 30%, 720 W). The observed values deviated from the predicted values by −3.45% and 6.42% for berberine and RSA IC50, respectively, thus indicating the validity of the selected models. The prepared extracts demonstrated antioxidant, anti-melanogenic, and anti-inflammatory activity, as well excellent α-glucosidase and α-amylase inhibitory activity. The displayed biological properties and lack of glycerol toxicity makes the prepared extracts suitable for direct inclusion into antidiabetic and dermatologic food supplements and topical products.
Correlation between Quality and Geographical Origins of Cortex Periplocae, Based on the Qualitative and Quantitative Determination of Chemical Markers Combined with Chemical Pattern Recognition
Authors: Gao Mengyuan , Jia Xiaohua , Huang Xuhua , Wang Wei , Yao Guangzhe , Chang Yanxu , Ouyang Huizi , Li Tianxiang , He Jun
Published: October 2019

Quality assessment of Cortex Periplocae remains a challenge, due to its complex chemical profile. This study aims to investigate the chemical components of Cortex Periplocae, including its non-volatile and volatile constituents, via liquid chromatograph–mass spectrometry (LC-MS/MS) and gas chromatography–mass spectrometry (GC-MS) assays. The established strategy manifested that Cortex Periplocae from different producing areas was determined by identifying 27 chemical markers with ultra-high-performance liquid chromatography, coupled with quadrupole tandem time-of-flight mass spectrometry (UPLC-Q-TOF-MS/MS), including four main groups of cardiac glycosides, organic acids, aldehydes, and oligosaccharides. These groups’ variable importance in the projection (VIP) were greater than 1. Simultaneously, the samples were divided into four categories, combined with multivariate statistical analysis. In addition, in order to further understand the difference in the content of samples from different producing areas, nine chemical markers of Cortex Periplocae from 14 different producing areas were determined by high performance liquid chromatography coupled with mass spectrometry (HPLC-MS/MS), and results indicated that the main effective constituents of Cortex Periplocae varied with places of origin. Furthermore, in GC-MS analysis, samples were divided into three groups with multivariate statistical analysis; in addition, 22 differential components whose VIP were greater than 1 were identified, which were principally volatile oils and fatty acids. Finally, the relative contents of seven main volatile constituents were obtained, which varied extremely with the producing areas. The results showed that the LC-MS/MS and GC-MS assays, combined with multivariate statistical analysis for Cortex Periplocae, provided a comprehensive and effective means for its quality evaluation.
Enhanced Kinetic Removal of Ciprofloxacin onto Metal-Organic Frameworks by Sonication, Process Optimization and Metal Leaching Study
Authors: Dehghan Aliakbar , Mohammadi Ali Akbar , Yousefi Mahmood , Najafpoor Ali Asghar , Shams Mahmoud , Rezania Shahabaldin
Published: October 2019

Metal-organic frameworks (MOFs) are currently recognized as unique platforms for environmental studies. This study evaluated the potential of nine MOFs from ZIF-8, ZIF-67, and UIO-66 families for the removal of ciprofloxacin (CIP), a toxic, bio-accumulative, and persistent fluoroquinolone antibiotic. ZIF-67-SO4, with a rhombic crystalline morphology and 1375 m2/g BET surface area, has the highest CIP adsorption efficiency among the studied MOFs. The mathematical sorption model predicted that the highest CIP removal (99.2%) occurs when adsorbent dose, pH, and agitation time are adjusted to 6.82, 832.4 mg/L, and 39.95 min, respectively. Further studies revealed that the CIP adsorbed onto ZIF-67-SO4 in monolayer (qmax: 2537.5 mg/g) and chemisorption controlled the rate of the process. Mass transfer kinetic coefficients improved significantly by sonication at 35 KHz in comparison with mechanical agitation. Thermodynamic parameters (minus signs of ∆G° [7.8 to 14.2], positive signs of ∆H° (58.9 KJ/mol), and ∆S° (0.23 KJ/mol·K)) demonstrated the spontaneous, endothermic, and chemical sorption of CIP. The level of cobalt leached from ZIF-67-SO4 structure varied 1.2–4.5 mg/L, depending on pH, mixing time, and agitation type. In conclusion, the excellent adsorption properties of ZIF-67-SO4 for CIP, made it an outstanding candidate for environmental protection purposes.
Bio-Mediated Synthesis and Characterisation of Silver Nanocarrier, and Its Potent Anticancer Action
Authors: Lee Kar Xin , Shameli Kamyar , Mohamad Shaza Eva , Yew Yen Pin , Mohamed Isa Eleen Dayana , Yap Hooi-Yeen , Lim Wei Ling , Teow Sin-Yeang
Published: October 2019

Discovery of a potent drug nanocarrier is crucial for cancer therapy in which drugs often face challenges in penetrating efficiently into solid tumours. Here, biosynthesis of silver nanoparticles (AgNPs) using a waste material, Garcinia mangostana (GM) fruit peel extract is demonstrated. The best condition for AgNPs synthesis was with 0.5 g of peel extract, 7.5 mM silver nitrate at 45 °C, ~pH 4 for 16 h. The synthesized AgNPs were spherical and 32.7 ± 5.7 nm in size. To test its efficiency to be used as drug carrier, plant-based drug, protocatechuic acid (PCA) was used as a test drug. AgNPs loaded with PCA (AgPCA) resulted in 80% of inhibition at 15.6 µg/mL as compared to AgNPs which only killed 5% of HCT116 colorectal cells at same concentration. The IC50 of AgNPs and AgPCA for HCT116 were 40.2 and 10.7 µg/mL, respectively. At 15.6 µg/mL, AgPCA was not toxic to the tested colon normal cells, CCD112. Ag-based drug carrier could also potentially reduce the toxicity of loaded drug as the IC50 of PCA alone (148.1 µg/mL) was higher than IC50 of AgPCA (10.7 µg/mL) against HCT116. Further, 24-h treatment of 15.6 µg/mL AgPCA resulted in loss of membrane potential in the mitochondria of HCT116 cells and increased level of reaction oxygen species (ROS). These could be the cellular killing mechanisms of AgPCA. Collectively, our findings show the synergistic anticancer activity of AgNPs and PCA, and its potential to be used as a potent anticancer drug nanocarrier.
Daily Fructose Traces Intake and Liver Injury in Children with Hereditary Fructose Intolerance
Authors: Di Dato Fabiola , Spadarella Simona , Puoti Maria Giovanna , Caprio Maria Grazia , Pagliardini Severo , Zuppaldi Claudia , Vallone Gianfranco , Fecarotta Simona , Esposito Gabriella , Iorio Raffaele , Parenti Giancarlo , Spagnuolo Maria Immacolata
Published: October 2019

Background: Hereditary fructose intolerance (HFI) is a rare genetic disorder of fructose metabolism due to aldolase B enzyme deficiency. Treatment consists of fructose, sorbitol, and sucrose (FSS)-free diet. We explore possible correlations between daily fructose traces intake and liver injury biomarkers on a long-term period, in a cohort of young patients affected by HFI. Methods: Patients’ clinical data and fructose daily intake were retrospectively collected. Correlations among fructose intake, serum alanine aminotransferase (ALT) level, carbohydrate-deficient transferrin (CDT) percentage, liver ultrasonography, genotype were analyzed. Results: We included 48 patients whose mean follow-up was 10.3 ± 5.6 years and fructose intake 169 ± 145.4 mg/day. Eighteen patients had persistently high ALT level, nine had abnormal CDT profile, 45 had signs of liver steatosis. Fructose intake did not correlate with ALT level nor with steatosis severity, whereas it correlated with disialotransferrin percentage (R2 0.7, p < 0.0001) and tetrasialotransferrin/disialotransferrin ratio (R2 0.5, p = 0.0001). p.A150P homozygous patients had lower ALT values at diagnosis than p.A175D variant homozygotes cases (58 ± 55 IU/L vs. 143 ± 90 IU/L, p = 0.01). Conclusion: A group of HFI patients on FSS-free diet presented persistent mild hypertransaminasemia which did not correlate with fructose intake. Genotypes may influence serum liver enzyme levels. CDT profile represents a good marker to assess FSS intake.
Dietary Protein, Exercise, and Frailty Domains
Authors: Schoufour Josje D. , Overdevest Elvera , Weijs Peter J. M. , Tieland Michael
Published: October 2019

Increasing awareness of the impact of frailty on elderly people resulted in research focusing on factors that contribute to the development and persistence of frailty including nutrition and physical activity. Most effort so far has been spent on understanding the association between protein intake and the physical domain of frailty. Far less is known for other domains of frailty: cognition, mood, social health and comorbidity. Therefore, in the present narrative review, we elaborate on the evidence currently known on the association between protein and exercise as well as the broader concept of frailty. Most, but not all, identified studies concluded that low protein intake is associated with a higher prevalence and incidence of physical frailty. Far less is known on the broader concept of frailty. The few studies that do look into this association find a clear beneficial effect of physical activity but no conclusions regarding protein intake can be made yet. Similar, for other important aspects of frailty including mood, cognition, and comorbidity, the number of studies are limited and results are inconclusive. Future studies need to focus on the relation between dietary protein and the broader concept of frailty and should also consider the protein source, amount and timing.
Innovations in Pediatric Drug Formulations and Administration Technologies for Low Resource Settings
Authors: Gerrard Stephen E. , Walsh Jennifer , Bowers Niya , Salunke Smita , Hershenson Susan
Published: October 2019

Despite advances in regulations and initiatives to increase pediatric medicine development, there is still an unmet need for age-appropriate medicines for children. The availability of pediatric formulations is particularly lacking in resource poor areas, due to, for example, area-specific disease burden and financial constraints, as well as disconnected supply chains and fragmented healthcare systems. The paucity of authorized pediatric medicines often results in the manipulation and administration of products intended for adults, with an increased risk of mis-dosing and adverse reactions. This article provides an overview of the some of the key difficulties associated with the development of pediatric medicines in both high and low resource areas, and highlights shared and location specific challenges and opportunities. The utilization of dispersible oral dosage forms and suppositories for low and middle-income countries (LMICs) are described in addition to other platform technologies that may in the future offer opportunities for future pediatric medicine development for low resource settings.
Identification and Functional Characterization of a Soybean (Glycine max) Thioesterase that Acts on Intermediates of Fatty Acid Biosynthesis
Authors: Tran Huong Thi Diem , Le Nhan Trong , Khuat Vy Le Uyen , Nguyen Thuong Thi Hong
Published: October 2019

(1) Background: Plants possess many acyl-acyl carrier protein (acyl-ACP) thioesterases (TEs) with unique specificity. One such TE is methylketone synthase 2 (MKS2), an enzyme with a single-hotdog-fold structure found in several tomato species that hydrolyzes 3-ketoacyl-ACPs to give free 3-ketoacids. (2) Methods: In this study, we identified and characterized a tomato MKS2 homolog gene, namely, GmMKS2, in the genome of soybean (Glycine max). (3) Results: GmMKS2 underwent alternative splicing to produce three alternative transcripts, but only one encodes a protein with thioesterase activity when recombinantly expressed in Escherichia coli. Heterologous expression of the main transcript of GmMKS2, GmMKS2-X2, in E. coli generated various types of fatty acids, including 3-ketoacids—with 3-ketotetradecenoic acid (14:1) being the most abundant—cis-Δ5-dodecanoic acid, and 3-hydroxyacids, suggesting that GmMKS2 acts as an acyl-ACP thioesterase. In plants, the GmMKS2-X2 transcript level was found to be higher in the roots compared to other examined organs. In silico analysis revealed that there is a substantial enrichment of putative cis-regulatory elements related to disease-resistance responses and abiotic stress responses in the promoter of this gene. (4) Conclusions: GmMKS2 showed broad substrate specificities toward a wide range of acyl-ACPs that varied in terms of chain length, oxidation state, and saturation degree. Our results suggest that GmMKS2 might have a stress-related physiological function in G. max.
Modelling and Kinetic Study of Novel and Sustainable Microwave-Assisted Dehydration of Sugarcane Juice
Authors: Alvi Tayyaba , Khan Muhammad Kashif Iqbal , Maan Abid Aslam , Nazir Akmal , Ahmad Muhammad Haseeb , Khan Muhammad Issa , Sharif Muhammad , Khan Azmat Ullah , Afzal Muhammad Inam , Umer Muhammad , Abbas Shabbar , Qureshi Shahnah
Published: October 2019

Sugarcane juice is a perishable food with a good nutritional profile. Thus, there is a need to increase its shelf life by reducing water content which facilitates storage and transportation. In this study, process conditions were optimized to concentrate the sugarcane juice at various microwave powers (30, 50, 80, 100 W). A central composite design was applied to optimize the process conditions (power and time). The overall evaporation time depends on microwave powers; increase in power reduced the processing time. The results showed that at 100 W sugarcane juice was concentrated to 75° brix for 15 min which reduced the energy consumption to 1.3 times compared to other powers. Moreover, microwave processing better retained the sensory properties of concentrate and preserved its antioxidant activity. Thus, 100 W was most energy efficient in concentrating sugarcane juice. In general, microwave processing reduced the processing time and cost making it a sustainable approach to concentrate juices.
Detecting Targets above the Earth’s Surface Using GNSS-R Delay Doppler Maps: Results from TDS-1
Authors: Hu Changjiang , Benson Craig , Park Hyuk , Camps Adriano , Qiao Li , Rizos Chris
Published: October 2019

Global Navigation Satellite System (GNSS) reflected signals can be used to remotely sense the Earth’s surface, known as GNSS reflectometry (GNSS-R). The GNSS-R technique has been applied to numerous areas, such as the retrieval of wind speed, and the detection of Earth surface objects. This work proposes a new application of GNSS-R, namely to detect objects above the Earth’s surface, such as low Earth orbit (LEO) satellites. To discuss its feasibility, 14 delay Doppler maps (DDMs) are first presented which contain unusually bright reflected signals as delays shorter than the specular reflection point over the Earth’s surface. Then, seven possible causes of these anomalies are analysed, reaching the conclusion that the anomalies are likely due to the signals being reflected from objects above the Earth’s surface. Next, the positions of the objects are calculated using the delay and Doppler information, and an appropriate geometry assumption. After that, suspect satellite objects are searched in the satellite database from Union of Concerned Scientists (UCS). Finally, three objects have been found to match the delay and Doppler conditions. In the absence of other reasons for these anomalies, GNSS-R could potentially be used to detect some objects above the Earth’s surface.
A Drag Model-LIDAR-IMU Fault-Tolerance Fusion Method for Quadrotors
Authors: Lyu Pin , Wang Bingqing , Lai Jizhou , Liu Shichao , Li Zhimin
Published: October 2019

In this paper, a drag model-aided fault-tolerant state estimation method is presented for quadrotors. Firstly, the drag model accuracy was improved by modeling an angular rate related item and an angular acceleration related item, which are related with flight maneuver. Then the drag model, light detection and ranging (LIDAR), and inertial measurement unit (IMU) were fused based on the Federal Kalman filter frame. In the filter, the LIDAR estimation fault was detected and isolated, and the disturbance to the drag model was estimated and compensated. Some experiments were carried out, showing that the velocity and position estimation were improved compared with the traditional LIDAR/IMU fusion scheme.
Design and Fabrication of CMOS Microstructures to Locally Synthesize Carbon Nanotubes for Gas Sensing
Authors: Roy Avisek , Azadmehr Mehdi , Ta Bao Q. , Häfliger Philipp , Aasmundtveit Knut E.
Published: October 2019

Carbon nanotubes (CNTs) can be grown locally on custom-designed CMOS microstructures to use them as a sensing material for manufacturing low-cost gas sensors, where CMOS readout circuits are directly integrated. Such a local CNT synthesis process using thermal chemical vapor deposition (CVD) requires temperatures near 900 °C, which is destructive for CMOS circuits. Therefore, it is necessary to ensure a high thermal gradient around the CNT growth structures to maintain CMOS-compatible temperature (below 300 °C) on the bulk part of the chip, where readout circuits are placed. This paper presents several promising designs of CNT growth microstructures and their thermomechanical analyses (by ANSYS Multiphysics software) to check the feasibility of local CNT synthesis in CMOS. Standard CMOS processes have several conductive interconnecting metal and polysilicon layers, both being suitable to serve as microheaters for local resistive heating to achieve the CNT growth temperature. Most of these microheaters need to be partially or fully suspended to produce the required thermal isolation for CMOS compatibility. Necessary CMOS post-processing steps to realize CNT growth structures are discussed. Layout designs of the microstructures, along with some of the microstructures fabricated in a standard AMS 350 nm CMOS process, are also presented in this paper.
An Amplifier-Less Acquisition Chain for Power Measurements in Series Resonant Inverters
Authors: Villa Jorge , Artigas José I. , Barragán Luis A. , Navarro Denis
Published: October 2019

Successive approximation register (SAR) analog-to-digital converter (ADC) manufacturers recommend the use of a driver amplifier to achieve the best performance. When a driver amplifier is not used, the conversion speed is severely penalized because of the need to meet the settling time constraint. This paper proposes a simple digital correction method to raise the performance (conversion speed and/or accuracy) when the acquisition chain lacks a driver amplifier. It is intended to reduce the cost, size and power consumption of the conditioning circuit while maintaining acceptable performance. The method is applied to the measurement of the output power delivered by a series resonant inverter for domestic induction heating.
A Fast 4K Video Frame Interpolation Using a Multi-Scale Optical Flow Reconstruction Network
Authors: Ahn Ha-Eun , Jeong Jinwoo , Kim Je Woo , Kwon Soonchul , Yoo Jisang
Published: October 2019

Recently, video frame interpolation research developed with a convolutional neural network has shown remarkable results. However, these methods demand huge amounts of memory and run time for high-resolution videos, and are unable to process a 4K frame in a single pass. In this paper, we propose a fast 4K video frame interpolation method, based upon a multi-scale optical flow reconstruction scheme. The proposed method predicts low resolution bi-directional optical flow, and reconstructs it into high resolution. We also proposed consistency and multi-scale smoothness loss to enhance the quality of the predicted optical flow. Furthermore, we use adversarial loss to make the interpolated frame more seamless and natural. We demonstrated that the proposed method outperforms the existing state-of-the-art methods in quantitative evaluation, while it runs up to 4.39× faster than those methods for 4K videos.
Trends in GP incomes in England, 2008–2017: a retrospective analysis of repeated postal surveys
Authors: Atkins Rose , Gibson Jon , Sutton Matt , Spooner Sharon , Checkland Katherine
Published: October 2019

Background

There is widespread concern over the recruitment and retention of GPs in England. Income is a fundamental consideration affecting the attractiveness of working in general practice.

Aim

To report on trends in average incomes earned by GPs in England, adjusted for inflation and contracted time commitment.

Design and setting

Postal surveys of random samples of GPs working in England in 2008, 2010, 2012, 2015, and 2017.

Method

Trends in average reported incomes of partner and salaried GPs were directly standardised for the reported number of sessions worked per week and adjusted for inflation.

Results

Data were obtained from between 1000 and 1300 responders each year, representing response rates between 25% and 44%. Almost all responders (96%) reported the income they earned from their job as a GP. Mean nominal annual income decreased by 1.1% from £99 437 in 2008 to £98 373 in 2017 for partner GPs and increased by 4.4% from £49 061 to £51 208 for salaried GPs. Mean sessions worked decreased from 7.7 to 7.0 per week for partner GPs and decreased from 5.6 to 5.3 per week for salaried GPs. Mean income adjusted for sessions worked and inflation decreased by 10.0% for partner GPs and by 7.0% for salaried GPs, between 2008 and 2017.

Conclusion

The decrease in GP income adjusted for sessions worked and inflation over the last decade may have contributed to the current problems with recruitment and retention.
Intertextualidade e metapoesia no Satyricon, de Petrônio
Authors: Marasco Franco Simone Sales
Published: October 2019

A intertextualidade é largamente utilizada por Petrônio como um recurso a mais para a construção de uma sociedade decadente, uma vez que a configuração e a caracterização de cada personagem são feitas de modo a confundir o leitor e levá-lo à reflexão. Com base nesses preceitos, alicerçados pelas contribuições acerca da intertextualidade de Bakhtin (1981) faremos uma leitura da obra de Petrônio à luz da intertextualidade para verificarmos seu processo de construção metapoética e suas contribuições para a crítica literária.
Cassandra em três tempos: bela, adivinha, trágica
Authors: Paoli Beatriz de
Published: October 2019

Se para nós, leitores modernos, os versos homéricos fizeram pouco mais do que consagrar a beleza de Cassandra, foram os versos de Píndaro que, por sua vez, reconheceram-na como adivinha, mas é à tragédia Agamêmnon, de Ésquilo, que os traços fundamentais que distinguem a figura de Cassandra e povoam nosso imaginário parecem inevitavelmente convergir. Este artigo propõe-se, assim, a discorrer sobre três momentos na representação da princesa troiana – o seu retrato homérico, pindárico e esquiliano –, enfatizando, sobretudo, nos textos analisados, a relação da personagem com o tempo passado, presente e futuro.
Field Tests on the Herbicide Tolerance of Various Maize Genotypes
Authors: Bónis Péter , Árendás Tamás , Marton Lajos Csaba
Published: October 2019

Investigations were made in Martonvásár on the herbicide tolerance of 22 inbred maize lines and 3 parental single crosses when treated with one herbicide applied after sowing, prior to emergence, and with seven applied post-emergence in the 6-8-leaf stage. Visible damage was scored 14 days after the treatment.An analysis of the phytotoxic effects led to the conclusion that a single dose of the tested herbicides did not cause any damage to the genotypes investigated, with the exception of one inbred line, which was extremely sensitive to herbicides of the sulphonyl carbamide type and moderately sensitive to both rates of dicamba. In many cases, a double dose of the herbicides caused mild or moderate symptoms on the maize lines.
L’incubation et l’éclosion des oeufs des vers à soie de chêne Antheraea pernyi Guer (Bombycidae)
Authors: Nueleanu Veturia - Ileana
Published: October 2019

In this paper we studied optimal conditions which need to be fulfilled in order to have successful incubation and hatching of eggs of the species Antheraea pernyi Guer.The incubation of the eggs of this species implies a proper environment: temperature of 18-21oC, relative humidity of 80%, unvarying light, aeration 2 or 3 times a day and a density of 50 g eggs for a 20/50 cm area.In these conditions, the incubation of the first generation lasts 10-12 days and of the second generation up to 8-10 days. The second generation needs higher temperatures (22-26oC) and higher humidity (optimal value 90%).In this species, hatching lasts 6-7 days, with a maximum during the second day; it takes place especially early in the morning.
A Educação do Campo e o Discurso da Interdisciplinaridade: reverberações nas enunciações discentes
Authors: Mittmann Verônica de Lima , Duarte Claudia Glavam
Published: October 2019

A interdisciplinaridade vem se constituindo como uma verdade que atravessa o campo educacional brasileiro na contemporaneidade. Neste sentido, este estudo teve como objetivo perceber quais enunciados sobre a interdisciplinaridade circulam no curso Licenciatura em Educação do Campo: Ciências da Natureza – campus Litoral Norte da Universidade Federal do Rio Grande do Sul – UFRGS. De forma específica, este artigo problematiza e apresenta uma análise do discurso na perspectiva foucaultiana de enunciações que emergiram nas falas dos discentes do referido curso ao justificarem a necessidade de um currículo interdisciplinar. Percebemos que a justificativa destes estudantes acaba duplicando enunciados que atravessam a enunciação de autores que são referência da Licenciatura em Educaçãodo Campo. Acreditamos que esta ressonância de enunciados poderá estar fortalecendo de forma concomitante tanto o Discurso da Interdisciplinaridade quanto o Discurso da Educação do Campo. Para este ensaio foram realizadas entrevistas com 32 discentes e as ferramentas teóricas utilizadas advêm da oficina de Michel Foucault.
Participação Popular, Educação e a Cidade para todos: compromisso com a cidadania
Authors: Silveira Gerveson Tramontin
Published: October 2019

Este artigo analisa a participação popular e a lógica democrática participativa no planejamento urbano na luta pela escola pública. É fruto de pesquisa desenvolvida no período de 1993 a 2000, no município de Ponta Grossa - PR. Tem como conceitos centrais a participação popular, a educação e a gestão pública, concebendo-os como elementos essenciais para a construção da cidadania e para a garantia de políticas públicas na área da educação. A partir da análise da participação popular, foi possível concluir que a conquista e a implementação de políticas públicas passam necessariamente pela mobilização, organização e participação popular na gestão pública.