bluuebunny/crossref_metadata_2025 huggingface dataset:
Mutation rate analysis via parent–progeny sequencing of the perennial peach. II. No evidence for recombination-associated mutation
Authors: Wang Long , Zhang Yanchun , Qin Chao , Tian Dacheng , Yang Sihai , Hurst Laurence D.
Published: October 2016

Mutation rates and recombination rates vary between species and between regions within a genome. What are the determinants of these forms of variation? Prior evidence has suggested that the recombination might be mutagenic with an excess of new mutations in the vicinity of recombination break points. As it is conjectured that domesticated taxa have higher recombination rates than wild ones, we expect domesticated taxa to have raised mutation rates. Here, we use parent–offspring sequencing in domesticated and wild peach to ask (i) whether recombination is mutagenic, and (ii) whether domesticated peach has a higher recombination rate than wild peach. We find no evidence that domesticated peach has an increased recombination rate, nor an increased mutation rate near recombination events. If recombination is mutagenic in this taxa, the effect is too weak to be detected by our analysis. While an absence of recombination-associated mutation might explain an absence of a recombination–heterozygozity correlation in peach, we caution against such an interpretation.
Semi-automated genome annotation using epigenomic data and Segway
Authors: Roberts Eric G. , Mendez Mickaël , Viner Coby , Karimzadeh Mehran , Chan Rachel , Ancar Rachel , Chicco Davide , Hesselberth Jay R. , Kundaje Anshul , Hoffman Michael M.
Published: October 2016

Biochemical techniques measure many individual properties of chromatin along the genome. These properties include DNA accessibility (measured by DNase-seq) and the presence of individual transcription factors and histone modifications (measured by ChIP-seq). Segway is software that transforms multiple datasets on chromatin properties into a single annotation of the genome that a biologist can more easily interpret. This protocol describes how to use Segway to annotate the genome, starting with reads from a ChIP-seq experiment. It includes pre-processing of data, training the Segway model, annotating the genome, assigning biological meanings to labels, and visualizing the annotation in a genome browser.
Collapse Precedes Folding in Denaturant-Dependent Assembly of Ubiquitin
Authors: Reddy Govardhan , Thirumalai D.
Published: October 2016

Despite the small size the folding of Ubiquitin (Ub), which plays an indispensable role in targeting proteins for degradation and DNA damage response, is complex. A number of experiments on Ub folding have reached differing conclusions regarding the relation between collapse and folding, and whether intermediates are populated. In order to resolve these vexing issues, we elucidate the denaturant-dependent thermodynamics and kinetics of Ub folding in low and neutral pH as a function of Guanidinium chloride and Urea using coarse-grained molecular simulations. The changes in the fraction of the folded Ub, and the radius of gyration (Rg) as a function of the denaturant concentration, [C], are in quantitative agreement with experiments. Under conditions used in experiments,Rgof the unfolded state at neutral pH changes only by ≈ 17% as the [GdmCl] decreases from 6 M to 0 M. We predict that the extent of compaction of the unfolded state increases as temperature decreases. A two-dimensional folding landscape as a function ofRgand a measure of similarity to the folded state reveals unambiguously that the native state assembly is preceded by collapse, as discovered in fast mixing experiments on several proteins. Analyses of the folding trajectories, under mildly denaturing conditions ([GdmCl]=1.0M or [Urea]=1.0M), shows that Ub folds by collision between preformed secondary structural elements involving kinetic intermediates that are primarily stabilized by long-range contacts. Our work explains the results of Small Angle X-Ray Scattering (SAXS) experiments on Ub quantitatively, and establishes that evolved globular proteins are poised to collapse. In the process, we explain the discrepancy between SAXS and single molecule fluorescent resonant energy transfer (smFRET) experiments, which have arrived at a contradicting conclusion concerning the collapse of polypeptide chains.
Automatic time-series phenotyping using massive feature extraction
Authors: Fulcher B. D. , Jones N. S.
Published: October 2016

Phenotype measurements frequently take the form of time series, but we currently lack a systematic method for relating these complex data streams to scientifically meaningful outcomes, such as relating the movement dynamics of a model organism to their genotype, or measurements of brain dynamics of a patient to their disease diagnosis. Here we report a new tool,hctsa, that automatically selects interpretable and useful properties of time series by comparing over 7 700 time-series features drawn from diverse scientific literatures. Using exemplar applications to high throughput phenotyping experiments, we show howhctsaallows researchers to leverage decades of time-series research to understand and quantify informative structure in time-series data.
Extinction rate has a complex and non-linear relationship with area
Authors: Keil Petr , Cabral Juliano S. , Chase Jonathan , Martins Ines S. , May Felix , Pereira Henrique M. , Winter Marten
Published: October 2016

Aim.

Biodiversity loss, measured as count of extinction events, is a key component of biodiversity change, and can significantly impact ecosystem services. However, estimation of the loss has focused mostly on per-species extinction rates measured over limited numbers of spatial scales, with no theory linking small-scale extirpations with global extinctions. Here we provide such link by introducing the relationship between area and per-species probability of extinction (PxAR) and between area and count of realized extinction events in that area (NxAR). We show theoretical and empirical forms of these relationships, and we discuss their role in perception and estimation of the current extinction crisis.

Location

USA, Europe, Czech Republic, Barro Colorado Island

Methods

We derived the expected forms of PxAR and NxAR from a range of theoretical frameworks based on theory of island biogeography, neutral models, and species-area relationships. We constructed PxAR and NxAR in five empirical datasets on butterflies, plants, trees and birds, collected over range of spatial scales.

Results

Both the theoretical arguments and empirical data support monotonically decreasing PxAR, i.e. per-species extinction probability decreasing with increasing area; however, we also report a rare theoretical possibility of locally increasing PxAR. In contrast, both theory and data revealed complex NxAR, i.e. counts of extinction events follow variety of relationships with area, including nonlinear unimodal, multimodal and U-shaped relationships, depending on region and taxon.

Main conclusions

The uncovered wealth of forms of NxAR can explain why biodiversity change (the net outcome of losses and gains) also appears scale-dependent. Furthermore, the complex scale dependence of PxAR and NxAR means that global extinctions indicate little about local extirpations, and vice versa. Hence, effort should be made to understand and report extinction crisis as a scale-dependent problem. In this effort, estimation of scaling relationships such as PxAR and NxAR should be central.
Whole genome resequencing of a laboratory-adaptedDrosophila melanogasterpopulation sample
Authors: Gilks William P. , Pennell Tanya M. , Flis Ilona , Webster Matthew T. , Morrow Edward H.
Published: October 2016

As part of a study into the molecular genetics of sexually dimorphic complex traits, we used next-generation sequencing to obtain data on genomic variation in an outbred laboratory-adapted fruit fly (Drosophila melanogaster) population. We successfully resequenced the whole genome of 2 females from the Berkeley reference line (BDGP6/dm6), and 220 hemiclonal females that were heterozygous for the same reference line genome, and a unique haplotype from the outbred base population (LHM). The use of a static and known genetic background enabled us to obtain sequences from whole-genome phased haplotypes. We used a BWA-Picard-GATK pipeline for mapping sequence reads to the dm6 reference genome assembly, at a median depth-of coverage of 31X, and have made the resulting data publicly-available in the NCBI Short Read Archive (BioProject PRJNA282591). Haplotype Caller discovered and genotyped 1,726,931 genetic variants (SNPs and indels, <200bp). Additionally, we used GenomeStrip/2.0 to discover and genotype 167 large structural variants (1-100Kb in size). Sequence data and quality-filtered genotype data are publicly-available at NCBI (Short Read Archive, dbSNP and dbVar). We have also released the unfiltered genotype data, and the code and logs for data processing, summary statistics, and graphs, via the research data repository, Zenodo, (https://zenodo.org/, ’Sussex Drosophila Sequencing’ community).
Hierarchical Evolutionary Preferences Explain Discrepancies in Expected Utility Theory
Authors: Price Michael Holton , Jones James Holland
Published: October 2016

The standard axiomatic theory of rationality posits that agents order preferences according to the average utilities associated with different choices. Expected Utility Theory has repeatedly failed as a predictive theory of choice behavior, as reflected in a growing literature in behavioral economics. Evolutionary theorists have suggested that seemingly irrational behaviors in contemporary contexts may have once served important functions, but there has been little attempt to formalize the relationship between evolutionary fitness and choice behavior. Biological agents should optimize fitness, but fitness itself is not a reasonable value function for decision-making since its time-scale exceeds the lifespan of the decision-maker. Consequently, organisms use proximate motivational systems that work on appropriate time-scales and are amenable to feedback and learning. We develop an evolutionary principal-agent model in which individuals maximize a set of proximal choice variables (age-specific demographic rates), the interests of which are aligned with fitness. The solution to our model yields pessimistic probability weightings compatible with the Rank-Dependent Expected Utility family of choice models. The pessimistic probability weighting characteristic of these models emerges naturally in an evolutionary framework because of extreme intolerance to zeros in multiplicative growth processes.
The effects of increasing the number of taxa on inferences of molecular convergence
Authors: Thomas Gregg W.C. , Hahn Matthew W. , Hahn Yoonsoo
Published: October 2016

Convergent evolution provides insight into the link between phenotype and genotype. Recently, large-scale comparative studies of convergent evolution have become possible, but researchers are still trying to determine the best way to design these types of analyses. One aspect of molecular convergence studies that has not yet been investigated is how taxonomic sample size affects inferences of molecular convergence. Here we show that increased sample size decreases the amount of inferred molecular convergence associated with the three convergent transitions to a marine environment in mammals. The sampling of more taxa—both with and without the convergent phenotype—reveals that alleles associated only with marine mammals in small datasets are actually more widespread, or are not shared by all marine species. The sampling of more taxa also allows finer resolution of ancestral substitutions, revealing that they are not in fact on lineages leading to solely marine species. We revisit a previous study on marine mammals and find that only 7 of the reported 43 genes with convergent substitutions still show signs of convergence with a larger number of background species. However, 4 of those 7 genes also showed signs of positive selection in the original analysis and may still be good candidates for adaptive convergence. Though our study is framed around the convergence of marine mammals, we expect our conclusions on taxonomic sampling are generalizable to any study of molecular convergence.
Design Specifications for Cellular Regulation
Authors: Krakauer David C. , Müller Lydia , Prohaska Sonja J. , Stadler Peter F.
Published: October 2016

A critical feature of all cellular processes is the ability to control the rate of gene or protein expression and metabolic flux in changing environments through regulatory feedback. We review the many ways that regulation is represented through causal, logical and dynamical components. Formalizing the nature of these components promotes effective comparison among distinct regulatory networks and provides a common framework for the potential design and control of regulatory systems in synthetic biology.
Functional determinants of protein assembly into homomeric complexes
Authors: Bergendahl L. Therese , Marsh Joseph A.
Published: October 2016

Approximately half of proteins with experimentally determined structures can interact with other copies of themselves and assemble into homomeric complexes, the overwhelming majority of which (>96%) are symmetric. Although homomerisation is often assumed to be functionally beneficial and the result of evolutionary selection, there has been little systematic analysis of the relationship between homomer structure and function. Here, utilizing the large numbers of structures and functional annotations now available, we have investigated how proteins that assemble into different types of homomers are associated with different biological functions. We observe that homomers from different symmetry groups are significantly enriched in distinct functions, and can often provide simple physical and geometrical explanations for these associations in regards to substrate recognition or physical environment. One of the strongest associations is the tendency for metabolic enzymes to form dihedral complexes, which we suggest is closely related to allosteric regulation. We provide a physical explanation for why allostery is related to dihedral complexes: it allows for efficient propagation of conformational changes across isologous (i.e.symmetric) interfaces. Overall we demonstrate a clear relationship between protein function and homomer symmetry that has important implications for understanding protein evolution, as well as for predicting protein function and quaternary structure.
SWALO: scaffolding with assembly likelihood optimization
Authors: Rahman Atif , Pachter Lior
Published: October 2016

Scaffoldingi.e.ordering and orienting contigs is an important step in genome assembly. We present a method for scaffolding based on likelihoods of genome assemblies. Generative models for sequencing are used to obtain maximum likelihood estimates of gaps between contigs and to estimate whether linking contigs into scaffolds would lead to an increase in the likelihood of the assembly. We then link contigs if they can be unambiguously joined or if the corresponding increase in likelihood is substantially greater than that of other possible joins of those contigs. The method is implemented in a tool called Swalowith approximations to make it efficient and applicable to large datasets. Analysis on real and simulated datasets reveals that it consistently makes more or similar number of correct joins as other scaffolders while linking very few contigs incorrectly, thus outperforming other scaffolders and demonstrating that substantial improvement in genome assembly may be achieved through the use of statistical models. Swalois freely available for download athttps://atifrahman.github.io/SWALO/.
An integrated metagenomics pipeline for strain profiling reveals novel patterns of bacterial transmission and biogeography
Authors: Nayfach Stephen , Rodriguez-Mueller Beltran , Garud Nandita , Pollard Katherine S.
Published: October 2016

We present the Metagenomic Intra-species Diversity Analysis System (MIDAS), which is an integrated computational pipeline for quantifying bacterial species abundance and strain-level genomic variation, including gene content and single-nucleotide polymorphisms (SNPs), from shotgun metagenomes. Our method leverages a database of more than 30,000 bacterial reference genomes that we clustered into species groups. These cover the majority of abundant species in the human microbiome but only a small proportion of microbes in other environments, including soil and seawater. We applied MIDAS to stool metagenomes from 98 Swedish mothers and their infants over one year and used rare SNPs to track strains between hosts. Using this approach, we found that although species compositions of mothers and infants converged over time, strain-level similarity diverged. Specifically, early colonizing bacteria were often transmitted from an infant’s mother, while late colonizing bacteria were often transmitted from other sources in the environment and were enriched for spore-formation genes. We also applied MIDAS to 198 globally distributed marine metagenomes and used gene content to show that many prevalent bacterial species have population structure that correlates with geographic location. Strain-level genetic variants present in metagenomes clearly reveal extensive structure and dynamics that are obscured when data are analyzed at a coarser taxonomic resolution.
Dairy farm financial performance: firm, year, and size effects
Authors: A. Wolf Christopher , Stephenson Mark W. , Knoblauch Wayne A. , Novakovic Andrew M.
Published: October 2016

Purpose

The purpose of this paper is to evaluate dairy farm financial performance over time utilizing farm financial ratios from three university business analysis programs. The evaluation includes measures of profitability, solvency, and liquidity by herd size.

Design/methodology/approach

Financial ratios to reflect profitability (rate of return on assets), solvency (debt to asset ratio), and liquidity (current ratio) were collected from Cornell University, Michigan State University, and the University of Wisconsin for dairy farms from 2000 to 2012. The distribution of farm financial performance using these ratios was examined over time and by herd size. Variance component methods are used to examine the percent of variation due to individual firm and industry aspects. A simple credit risk score is calculated to examine relative farm risk.

Findings

Dairy farm profitability performance is similar across herd sizes in poor years but larger herds realized significantly more profitability in good years. Findings were similar with respect to liquidity. Large herds consistently carried relatively more debt. Large herds’ financial performance was more uniform than across smaller herds. Larger herds had more financial risk as measured by credit risk scoring but recovered quickly to industry averages in profitable years.

Originality/value

The variation of dairy farm financial performance in an era of volatile milk and feed price is assessed. The results have important implications for farm financial management and benchmarking farm financial performance. In addition to helping to evaluate the efficacy of various price and income risk management tools, these results have important implications for understanding the benefits of the new federal Margin Protection Program for Dairy that is available to all US dairy farmers.
Estimating performance from capabilities in business process improvement
Authors: Nicholds Boyd A. , Mo John P.T.
Published: October 2016

Purpose

The research indicates there is a positive link between the improvement capability of an organisation and the intensity of effort applied to a business process improvement (BPI) project or initiative. While a degree of stochastic variation in applied effort to any particular improvement project may be expected there is a clear need to quantify the causal relationship, to assist management decision, and to enhance the chance of achieving and sustaining the expected improvement targets. The paper aims to discuss these issues.

Design/methodology/approach

The paper presents a method to obtain the function that estimates the range of applicable effort an organisation can expect to be able to apply based on their current improvement capability. The method used analysed published data as well as regression analysis of new data points obtained from completed process improvement projects.

Findings

The level of effort available to be applied to a process improvement project can be expressed as a regression function expressing the possible range of achievable BPI performance within 90 per cent confidence limits.

Research limitations/implications

The data set applied by this research is limited due to constraints during the research project. A more accurate function can be obtained with more industry data.

Practical implications

When the described function is combined with a separate non-linear function of performance gain vs effort a model of performance gain for a process improvement project as a function of organisational improvement capability is obtained. The probability of success in achieving performance targets may be estimated for a process improvement project.

Originality/value

The method developed in this research is novel and unique and has the potential to be applied to assessing an organisation’s capability to manage change.
Project cost control: a new method to plan and control costs in large projects
Authors: Jayaraman R.
Published: October 2016

Purpose

The purpose of this paper is to reengineer the process of cost management in large projects.

Design/methodology/approach

Considering the fact most large projects overrun their budgets because of the long time period needed to completion, it was decided to reengineer the cost management. Accordingly costs allocated to packages were reviewed and changed on a dynamic basis. Different types of contingencies were provided. Concepts of package contingency and project contingency were introduced. These were based on the project buffer and feeding buffer concepts popularised by Eliyahu Goldratt.

Findings

The re-engineered method of cost control worked well and yielded better than expected results, leading to the setting up of a new world record in the completion time for setting up a million tonnes per annum continuous, tandem cold rolling mill to roll steel sheets.

Research limitations/implications

In view of the total success of the reengineered approach, which was tested out on a large project over three years, it is felt that other projects could also try out this technique, especially since it is along the lines proposed by Eliyahu Goldratt who is an authority on project management. However the success can be better understood if the results of the testing become available. To that extent the contents of the present paper have limitations.

Practical implications

Large projects can deploy the methodology and complete their projects on time and under budget.

Social implications

The reengineering of the cost management was done primarily with a view to complete projects under budget. Since many governments spend many billions of dollars on publicly funded projects for the welfare of citizens, the use of this technique could have a salutary effect on the cost.

Originality/value

The method was innovated in the company by the author’s team and deployed in a live project over four years for the first time to achieve world-class results.
Best management practices adoption to mitigate non-point source pollution
Authors: Paudel Krishna P. , Devkota Nirmala , Tan Ying
Published: October 2016

Purpose

The purpose of this paper is to address the issues of correlated events and individual heterogeneity in multiple best management practices (BMPs) adoption.

Design/methodology/approach

The authors used survey data collected from broiler producers in Louisiana, USA. The authors estimated several duration models that either considered event dependence or heterogeneity or both.

Findings

Results from the conditional frailty model indicated that large farms adopt BMPs earlier, farmers who have been in broiler farming profession for a long time are late to adopt BMPs and more informed farmers, through contact with extension agents and education, are early adopters of BMPs.

Research limitations/implications

The limitation of this study is that the authors did not validate the robustness of the conditional frailty model using a more rigorous approach, such as empirical simulation method.

Practical implications

Many farmers do not adopt a new technology immediately after it becomes available. Duration models help to understand why farmers wait and how long they wait before adopting a new technology. In case of correlated events, where farmers adopt more than one technology, it is important to know the driving factors behind multiple technologies adoption. The findings from this study should help to properly target farmers to increase the adoption rate of a desired BMP.

Originality/value

This is the first study in agriculture technology adoption literature that uses a conditional frailty model to understand why farmers wait to adopt a new technology. This study also addresses both dependence in BMP adoption and heterogeneity in farmers’ quality that impact technology adoption.
The new rural social pension program in rural China: participation and its correlates
Authors: Zhao Qiran , Brosig Stephan , Luo Renfu , Zhang Linxiu , Yue Ai , Rozelle Scott
Published: October 2016

Purpose

The need for a universal rural pension system has been heightened by demographic changes in rural China, including the rapid aging of the nation’s rural population and a dramatic decline in fertility. In response to these changes, China’s Government introduced the New Rural Social Pension Program (NRSPP) in 2009, a voluntary and highly subsidized pension scheme. The purpose of this paper is to assess the participation of rural farmers in the NRSPP. Furthermore, the authors examine whether the NRSPP affects the labor supply of the elderly population in China.

Design/methodology/approach

This paper uses household-level data from a sample of 2,020 households originating from a survey conducted by the authors in five provinces, 25 counties, and 101 villages in rural China. Using a probit model and conducting correlation analysis, the authors demonstrate the factors affecting the participation and the impact of NRSPP on labor supply of the rural elderly.

Findings

The results show there are several factors that are correlated with participation, such as specific policy variant in force in the respective household's province, the size of the pension payout from government, the age of sample individuals, and the value of household durable assets. Specifically, different characteristics of NRSPP policy implementation increase participation in China’s social pension program. The results suggest that the introduction of the NRSPP has not affected the labor supply of the rural elderly, in general, although it has reduced participation for the elderly who were in poor health.

Originality/value

Several previous studies have covered the NRSPP. However, all previous studies were based on case studies or just focused on a small region, and for this reason the results cannot reflect the populations and heterogeneity of rural areas. Therefore, a data set with a large sample size is used in this paper to provide a new perspective to fully understand the participation of NRSPP and its impacts on rural households. This paper will make an update contribution to the literature in the area of pension programs in China.
Trends and determinants of rural residential solid waste collection services in China
Authors: Wang Aiqin , Shi Yaojiang , Gao Qiufeng , Liu Chengfang , Zhang Linxiu , Johnson Natalie , Rozelle Scott
Published: October 2016

Purpose

The purpose of this paper is to describe the trends in residential solid waste collection (RSWC) services in rural China over the past decade and analyze the determinants of these services using nationally representative data.

Design/methodology/approach

The authors draw on panel data from three rounds of village-level surveys of 101 villages. The three surveys were conducted in 2005, 2008, and 2012 in five provinces. The authors used fixed-effected regression approach to analyze the determinants of these services.

Findings

The results show that in the aftermath of increased investment and policy attention at the national level, the proportion of villages providing RSWC services in rural China increased significantly from 1998 to 2011. However, half of all villages in rural China still did not provide RSWC services as of 2011. Based on econometrics analysis, the authors show that villages that are richer, more populous, and villages with more small hamlets are more likely to provide RSWC services.

Originality/value

The analyses are based on primary survey data and the first to quantify trends in waste management services in the beginning of the twentieth century. The authors believe that the results will have significant policy implications for China in its continuing quest for better waste management policy.
Inequities in the allocation of medical resources in China’s Township Health Centers
Authors: Ma Yue , Zhang Linxiu , Boswell Matthew
Published: October 2016

Purpose

The purpose of this paper is to produce a high-quality measure of the nature of healthcare resources available in China’s Township Health Centers (THCs), paying particular attention to equity between high- and low-income areas.

Design/methodology/approach

This study makes use of data from a nearly nationally representative survey in rural China conducted by the Center for Chinese Agricultural Policy at the Chinese Academy of Sciences in 2011. The samples of towns were selected randomly from 25 counties located in five provinces from different regions of China. Data were collected through questionnaires and direct observation.

Findings

The THCs located in rich areas have higher levels of human resources than poor areas. THCs in rich areas also have more fixed assets than those in poor areas. In fact, even though the Chinese Ministry of Health mandates that all THCs have certain basic levels of medical equipment and facilities, many THCs in poor areas do not have them. The allocation of mandated equipment is unequal.

Practical implications

These findings suggest that China’s government should pay more attention to THCs located in poor areas, especially in light of new initiatives to improve health care in poor rural areas.

Originality/value

This is the first nationally representative study to employ rigorous empirics to investigate the extent of inequality in allocation of resources within THCs across China.
Facilitating employee socialization through mentoring relationships
Authors: Son SuJin
Published: October 2016

Purpose

The purpose of this paper is to advance understanding of the mentor factors that promotes mentoring outcomes. This was done by investigating the role of mentors’ learning goal orientation (LGO), their learning activity such as reflection, the perceived relationship quality in relation to the mentoring functions received by protégés, and the furtherance of their socialization in a formal mentoring relationship.

Design/methodology/approach

In total, 131 matched mentor-protégé dyads were recruited from three different organizations in Korea, for the final analysis. Structural equation modeling and Hayes's PROCESS macro were used to test the proposed model and the moderating effect of perceived relationship quality.

Findings

Results show that mentors’ LGO was positively related to their reflection. Additionally, mentors’ reflection was positively associated with mentoring functions received by protégés. Further, mentoring functions received by protégés were positively related to protégés’ socialization. In particular, mentors’ reflection mediates the relationship between mentors’ LGO and mentoring functions received by protégés. Moreover, perceived relationship quality moderates the relationship between mentors’ LGO and their reflection.

Originality/value

Even though mentoring research is well advanced, not many researches have yet investigated mentors’ LGO and their learning activity such as reflection, in relation to mentoring functions received by protégés and their socialization.
Opting-out and opting-in: a review and agenda for future research
Authors: Zimmerman Lauren M. , Clark Malissa A.
Published: October 2016

Purpose

The purpose of this paper is to highlight an emerging and evolving area within women’s careers literature – women’s opting-out and opting-in experiences. Highlights from several career theories, extant research, and a framework for women’s opting-out and opting-in experiences are discussed as well as future research considerations for women’s career breaks.

Design/methodology/approach

The present study provides the first synthesis of the theoretical and empirical work on women’s opting-out and opting-in experiences, by providing a framework that integrates existing research with the kaleidoscope career model. Published works from 1986 until the present were considered from psychology, management, sociology, and economics literatures.

Findings

This paper provides information about how women’s experiences of opting-out and opting-in to the workforce have emerged and evolved over the past few decades. Theoretical foundations, quantitative and qualitative research findings, and considerations for future research are discussed.

Practical implications

This paper is a useful source of information regarding an emerging and evolving area of studying within the women’s career literature. The paper discusses considerations for scholars and practitioners regarding developing, supporting, and retaining female talent amidst women’s career break experiences.

Originality/value

This paper provides an integrative framework that provides theoretical and empirical perspectives on the changing nature of women’s career values and choices, which influences their experiences of opting-out and opting-in to the workforce. Given both the changing demographics of the current workforce (e.g. increased women’s participation in the workforce) and women’s career values, research on women’s career breaks is warranted.
Lean and Six Sigma in logistics: a pilot survey study in Singapore
Authors: Zhang Abraham , Luo Wen , Shi Yangyan , Chia Song Ting , Sim Zhi Hao Xavier
Published: October 2016

Purpose

Lean and Six Sigma are the two most powerful methodologies for process improvement. They have been widely employed in manufacturing and healthcare industries to achieve substantial cost savings and quality improvement. The purpose of this paper is to investigate the implementation of Lean and Six Sigma for improving logistics operations.

Design/methodology/approach

A survey was conducted among 410 companies registered under the Singapore Logistics Association and returned 32 usable responses. χ2-tests were used to identify factors affecting the implementation of Lean and Six Sigma.

Findings

It was found that 37.5 per cent of respondents had implemented Lean and the majority of them had implemented Six Sigma together. All implementing companies reported varying degrees of cost savings and productivity improvements. Large logistics companies are more likely to implement Lean and Six Sigma. Companies with a higher service standard are more likely to implement Six Sigma.

Research limitations/implications

The survey was limited to Singapore. Future studies should explore a broader geographical coverage and improve the response rate.

Practical implications

Lean and Six Sigma are applicable for improving logistics operations. Senior management must be committed to support an implementation. Effective training and communications are required for overcoming resistance to change and helping employees to understand improvement methodologies and initiatives.

Originality/value

This research is the very first survey study of Lean and Six Sigma in the logistics industry. It reveals similarities and differences in comparison with the implementation of these methodologies in the manufacturing industry. The findings offer valuable insights for improving logistics operations.
Winning the competition for supplier resources
Authors: Pulles Niels J. , Veldman Jasper , Schiele Holger
Published: October 2016

Purpose

This paper examines the competition between buying firms for the supplier’s competitive resources. The purpose of this paper is to examine how indirect capabilities – the ability to access external resources – can help in obtaining preferential resource allocation from suppliers.

Design/methodology/approach

Partial least squares structural equation modeling is used to analyze data of 163 buying firms that assess preferential resource allocation from suppliers.

Findings

Two indirect capabilities (a buying firm’s selection capability and relational capability) positively influence the firm’s competitive advantage. These relations are significantly mediated by preferential resource allocation of suppliers. The impact of preferential resource allocation appeared stronger for manufacturing firms than for service firms.

Research limitations/implications

This study’s data set represents the buyer’s assessment of suppliers’ resource allocation. Future research should aim for dyadic data for further validation. In addition, due to sample size limitations, this study’s data does not allow sector segmentation. A larger study that provides insights into segmentation is suggested for future research.

Practical implications

The results inform managers about the relevance of the competition for supplier resources with rival firms that share suppliers, and the influence of this competition on firm competitiveness. Managers should not only focus on the supplier itself, but also on the capabilities of the supply chain management (SCM) function to recognize and integrate the supplier resources.

Originality/value

This study adds to the extended resource-based view literature by integrating the notion of supplier resource competition. In addition, the study shows the importance of indirect capabilities for obtaining preferential resource allocation from suppliers. Finally, the authors show the importance of separating between service and manufacturing when examining SCM practices.
Integrated resource efficiency: measurement and management
Authors: Koh S.C.L. , Morris Jonathan , Ebrahimi Seyed Mohammad , Obayi Raymond
Published: October 2016

Purpose

Drawing on the systems theory and the natural resource-based view, the purpose of this paper is to advance an integrated resource efficiency view (IREV) and derive a composite “integrated resource efficiency index” (IRE-index) for assessing the environmental, economic, and social resource efficiencies of production economies.

Design/methodology/approach

Using sub-national input-output data, the IRE-index builds on the human development index (HDI) and the OECD green growth indicators by including functions for environmental resource efficiency, energy, and material productivity. The study uses multiple regressions to examine and compare the IRE-index of 40 countries, including 34 OECD nations. The study further compares the IRE-index to similar composite indicators such as the human sustainable development index (HSDI) and the ecological footprint.

Findings

The IRE-index reveals a discrepancy between social development and resource efficiency in many of the world’s wealthiest production economies. Findings also show that material productivity has been the key driver for observed improvements in IRE over time. The index is a robust macro-level methodology for assessing resource efficiency and sustainability, with implications for production operations in global supply chains.

Originality/value

The IREV and IRE-index both contribute towards advancing green supply chain management and sustainability, and country-level resource efficiency accounting and reporting. The IRE-index is a useful composite for capturing aggregate environmental, economic, and social resource efficiencies of production economies. The paper clearly outlines the managerial, academic, and policy implications of the IREV and resulting index.
A transaction cost economics model for estimating performance effectiveness of relational and contractual governance
Authors: Wacker John G. , Yang Chenlung , Sheu Chwen
Published: October 2016

Purpose

As outsourcing continues to grow, supplier management becomes critical to the success of manufacturing firms. Transaction cost economics (TCE) suggests that firms should choose supplier governance mechanisms to ensure fulfillment of contractual obligations and safeguard against opportunism for their outsourcing activities. Accordingly, the purpose of this paper is to examine how buying organizations govern supplier contracts to improve manufacturing competitiveness and financial performance. The relative effectiveness of two primary governance mechanisms, contractual governance (CG), and relational governance, are examined.

Design/methodology/approach

Expanding upon previous studies, this study delineates three relational governance mechanisms (negotiation efficiency (NE), problem solving relations, and information sharing (IS)) that are conceptually, statistically and pragmatically different. Based on the TCE literature, a conceptual model is developed to decipher the relationships between pre-contract conditions (supplier asset specificity and environmental uncertainty (EU)), governance mechanisms, performance ambiguity (PA), and performance. Using the data collected from 987 firms, the statistical results present several important findings that would advance current theory and practice in outsourcing.

Findings

The authors find empirical support for the effects of contractual and relational governance in improving manufacturing and financial performance. The governance of supplier contracts clearly facilitates manufacturers’ ability to leverage their resources to improve performance. The relative effectiveness of these two governance mechanisms is related to the levels of EU and supplier asset specificity. Relational governance displays greater influence on performance than CG does. However, CG appears to be complementary to relational governance.

Research limitations/implications

The interplays between supplier asset specificity and EU should be examined in the future. The relationships among NE, IS, and problem solving should also be examined to facilitate the development of relational governance.

Practical implications

Managers should be aware of the situational performance of governance mechanisms. Moreover, it is important to realize how differently each of the three relational governance mechanisms and CG contribute to performance.

Originality/value

This study extends the academic discussion of supplier governance by investigating the alignment of governance mechanisms (relational governance and CG) with pre-contract conditions to reduce PA and, thereby, enhance manufacturing performance. Under the theoretical framework of TCE, the direct and indirect effects of pre-contract conditions and governance variables are fully examined and discussed. Moreover, relational governance involves multiple mechanisms that are conceptually and pragmatically different, and future studies should not treat it as one single construct.
Researching business interaction: introducing a conceptual framework and methodology
Authors: Abrahamsen Morten H.
Published: October 2016

Purpose

The purpose of this paper is to introduce a conceptual framework and a methodology for researching business interaction.

Design/methodology/approach

The paper briefly presents what business interaction is from an international marketing and purchasing perspective. It then discusses some epistemological and methodological challenges that this understanding implies, particularly concerning the time (when) and space (where) dimensions of interaction, the unit of analysis when researching interaction (who interacts), how the actors explain or make sense of interaction (why they interact), and the way in which (how) they interact. The paper subsequently introduces a conceptual framework that enables analysing interaction on the principal dimensions of time (the past, present, and the future) and space (actor, dyadic, and network level), and the ascription or explanation of these dimensions by the actors involved.

Findings

This framework is then applied to interview data from an empirical case study that demonstrates its methodological as well as practical application as a research technique. The paper ends with a discussion on how this framework can enhance the understanding of business interaction as researchers.

Originality/value

The data collection and analysis technique represents a novel way to collect, systematise, and analyse qualitative data that will hopefully add to the understanding of business interaction.
Wroe Alderson, IMP and the evolution of theory
Authors: Gadde Lars-Erik , Hulthén Kajsa
Published: October 2016

Purpose

The purpose of this paper is to analyse how theories evolve within scientific fields: why they receive attention and why they eventually become less attractive.

Design/methodology/approach

The paper is based on a literature review and focusses on the theoretical structure developed by Wroe Alderson. His contributions were highly appreciated and generally considered as “the” marketing theory. However, in few years his broad perspective was more or less neglected within the field where it was developed. At the same time, Alderson’s basic thinking was adopted by the evolving IMP approach. The specific objective of the study is to analyse why researchers in marketing abandoned Alderson, while IMP adopted many of his ideas.

Findings

The paper illustrates significant aspects of the evolution of theories. First, the paper shows how well-established conceptualisations, like Alderson’s total systems approach, may lose impact when the focus of research shifts. Alderson’s holistic framing was found too broad and all-encompassing to be useful when research attention was directed to specific aspects of marketing management and the socio-behavioural approach to distribution. Second, the paper shows in what respect IMP found support in concepts and models presented by Alderson in the challenging of fragmented mainstream framings of the business landscape.

Originality/value

This paper relates the rise and fall of Alderson’s concepts and frameworks to the evolution of theories of other schools-of-thought. Furthermore, the study shows how Alderson’s ideas were adapted to other research fields than where it was originally developed.