bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Investigation of the Effect of the Machine Kinematic Behavior on the Surface Topography and Roughness in High Speed Ball end Milling of the AISI4142 Steel
Authors: Lotfi Sai , Rami Belguith , Maher Baili , Gilles Desseins , Wassila Bouzid
Published: February 2021

The analysis of the surface topography in ball end milling is an objective studied by many researchers, several methods were used and many combinations of cutting conditions and machining errors are considered. In the milling tool paths the trajectories presents a points of changing direction where the tool decelerates before and accelerates after respecting the velocity profiles of the machine. In this paper, we propose experimental investigations of the effect of the kinematic behavior of the machine tool on the surface quality. A poor topography and roughness are remarked on the deceleration and the acceleration zones compared to the stationary zone.
Clinical Significance of PLIF in Restoring L4-S1 Segmental Lordosis of 2-level Isthmic Spondylolisthesis
Authors: Wang Jing-Yu , Liu Fu-Sheng , Li Jing , Wang Xiao-Bin
Published: February 2021

Background: Spinal and pelvic sagittal plane balance is closely related to good clinical prognosis, so in the treatment of 2-level isthmic spondylolisthesis, attention should be paid not only to adequate nerve decompression, but also to the correction of lumbosacral sagittal plane parameters. The purpose of this study was to observe the clinical prognosis and sagittal parameters of patients with isthmic spondylolisthesis treated with PLIF, and to find out the risk factors leading to poor prognosis. Methods: From January 2006 to August 2018, the clinical data of patients with 2-level isthmic spondylolisthesis treated with PLIF in the Second Xiangya Hospital of Central South University were retrospectively collected. The clinical symptoms (JOA score and VAS score) and the sagittal parameters of lumbosacral segment (PI, PT, LL, L4-S1 SL, LDI, PI-LL, LL and L4-S1 SL) were recorded before operation, immediately after operation and at the last follow-up. According to the improvement rate of JOA score, the patients were divided into two subgroups, poor(P) group and good(G) group. The parameters within and between the two subgroups were compared. Meanwhile, Pearson correlation analysis was conducted between sagittal parameters and JOA score improvement rate.Results: A total of 52 patients were enrolled in this study, the average age was (59.96 ±9.11) years, and the mean follow-up time was (31.88 ±8.37) months. Group G (n = 37) and group P (n = 15). In terms of clinical symptom improvement and sagittal plane parameters, except PI, the other parameters of the patients were improved compared with those before operation, and the difference was statistically significant. In the intra-group comparison, except PI, other indexes in group G were significantly improved, while in group P, there was no significant difference in PI, LL, L4-S1 SL, LDI, PI-LL before and after operation. In the comparison between groups, there was no significant difference in baseline data between group G and group P; postoperative VAS score(back pain) in group G was lower than that in group P, but there was no significant difference in VAS score( leg pain); in terms of JOA score and JOA score improvement rate, group G was significantly better; △L4-S1 SL ,L4-S1 SL and LDI were larger in group G, and the proportion of patients with normal LDI was higher than that in group P. Pearson correlation analysis showed that postoperative △L4-S1 SL, LDI and L4-S1 SL were positively correlated with JOA improvement rate. 2 patients with failed internal fixation occurred in group P, and the postoperative LDI was less than 50%. Conclusion: PLIF is an effective method for the treatment of 2-level isthmic spondylolisthesis. ΔL4-S1 SL, L4-S1 SL and good LDI may be important sagittal parameters affecting the clinical prognosis of L4 and L5 isthmus spondylolisthesis.
Successful Eradication of Mycoplasma Hyopneumoniae from the Norwegian Pig Population – 10 Years Later
Authors: Gulliksen Stine Margrethe , Baustad Børge , Framstad Tore , Jørgensen Anne , Skomsøy Audun , Kjelvik Oddbjørn , Gjestvang Mona , Grøntvedt Carl Andreas , Lium Bjørn
Published: February 2021

BackgroundMycoplasma hyopneumoniae (Mhyo) is the causative agent of enzootic pneumonia in pigs which adversely affects animal health and welfare, in addition to causing considerable economical losses. This paper presents the implementation of the national Mhyo eradication program in Norway, the subsequent population wide surveillance and documentation on the current freedom from Mhyo in the Norwegian pig population.In 1994, The board of The Norwegian Pig Health Service decided on conducting a national surveillance and eradication program for Mhyo. The program aimed for population wide freedom from Mhyo, based on serological surveillance. A partial depopulation program was initiated in all Mhyo positive farrow-to-feed and farrow-to-finish herds. Total depopulation was performed in all positive herds with finishing pigs. ResultsFrom 1994 to 2009, a total of 138 635 pigs in 3215 herds were serologically tested for the presence of antibodies against Mhyo. Of these, 5538 (4%) individual samples and 398 (12.4%) of the herds were defined as positive. In 2009, the Norwegian pig population was declared free from Mhyo, and has been so since then. From 2009 through 2019, a total of 44 228 individual serum samples have been analyzed for the presence of antibodies against Mhyo and found negative in the National surveillance program.ConclusionEradication of Mhyo infections has resulted in improved health and welfare of the Norwegian pig population. The success of the strategy is based on numerous factors, such as moderate to low prevalence of the agent, well documented and effective eradication protocols, accurate diagnostic tests, negligible import of live pigs, a well-structured commercial pig population, relatively small herds, low herd density in most parts of the country, and finally, the loyalty and significant effort of farmers, abattoir employees and veterinarians. To maintain the infection-free status at national level, a continuous alertness is required in the future to discover possible Mhyo infections and ensure rapid sampling and diagnostics. Any findings of Mhyo positive pig herds in Norway will result in immediate eradication.
SalmoSim: the development of a three-compartment in vitro simulator of the Atlantic Salmon GI tract and associated microbial communities
Authors: Kazlauskaite Raminta , Cheaib Bachar , Heys Chloe , Ijaz Umer Zeeshan , Connelly Stephanie , Sloan William , Russell Julie , Rubio Laura Martinez , Sweetman John , Kitts Alex , McGinnity Philip , Lyons Philip , Llewellyn Martin
Published: February 2021

BackgroundAtlantic salmon are a fish species of major economic importance. Innovative strategies are being sought to improve salmon feeds and feed additives to enhance fish performance, welfare, and the environmental sustainability of the aquaculture industry. There is still a lack of knowledge surrounding the importance and functionality of the salmon gut microbiome in fish nutrition. In vitro gut model systems might prove a valuable tool to study the effect of feed, and additives, on the host’s microbial communities. Several in vitro gut models targeted at monogastric vertebrates are now in operation. Here, we report the development of an Atlantic salmon gut model, SalmoSim, to simulate three gut compartments (stomach, pyloric caecum and midgut) and associated microbial communities. ResultsThe gut model was established in a series of linked bioreactors seeded with biological material derived from farmed adult marine phase salmon. In biological triplicate, the response of the in vitro system to two distinct dietary formulations (fish meal and fish meal free) was compared to a parallel in vivo trial over forty days. Metabarcoding based 16S rDNA sequencing, qPCR, ammoniacal nitrogen and volatile fatty acid measurements were undertaken to survey the microbial community dynamics and function. SalmoSim microbiomes were indistinguishable (p=0.230) from their founding inocula at 20 days and the most abundant genera (e.g. Psycrobacter, Staphylococcus, Pseudomonas) proliferated within SalmoSim. Real salmon and SalmoSim responded similarly to the introduction of novel feed, with majority of the taxa (96% Salmon, 97% SalmoSim) unaffected, while a subset of taxa (e.g. a small fraction of Psychrobacter) were differentially affected across both systems. Consistent with a low impact of the novel feed on microbial fermentative activity, volatile fatty acids profiles were not significantly different in SalmoSim pre- and post-feed switch.ConclusionThis study represents an important step in the development of an in vitro gut system as a tool for the improvement of salmon nutrition and welfare. This system aims to be utilised as a pre-screening tool for new feed ingredients and additives, as well as being used to study antimicrobial resistance and transfer, and fundamental ecological processes that underpin microbiome dynamics and assembly.
Changes in Soil Zinc Chemical Fractions and Improvements in Wheat Grain Quality in Response to Zinc Solubilising Bacteria
Authors: Niko Banafsheh Rezaei , enayatizamir naeimeh , Masir Mojtaba Nourozi
Published: February 2021

This study was performed to investigate the impacts of two indigenous strains of zinc (Zn) solubilising bacteria on Zn fractionation in soil, Zn uptake and the molar ratio of phytic acid to Zn (PA/Zn) in wheat grain cv. Chamran. The experiment was implemented in a completely randomised factorial design that included the treatment of bacterial inoculation consisting of B0 (control), B1 (Bacillus megaterium), B2 (Enterobacter cloacae), B3 (a mixed inoculation of both bacteria), and ZnSO4 fertiliser at three application levels: Zn0 (control), Zn1 (5.1mgkg-1), and Zn2 (10.1mgkg-1). Bacillus megaterium was isolated from the rhizosphere of Zea mays, which can solubilise Zn and phosphate and produce auxin. Enterobacter cloacae, which had been isolated from sugarcane root, was screened qualitatively and determined to be the best isolate to solubilise Zn. The results indicated the maximum values of organically bound (2.08 mg kg-1) and exchangeable Zn (0.89 mg kg-1) in the Zn2B3 treatment. Also, the highest amounts of carbonate bound (9.25 mg kg-1), FeMn-oxides (10.70 mg kg-1), and residual fractions (16.17 mg kg-1) were recorded for the Zn2B0 treatment. The relative proportions of residual, FeMn-oxides, carbonate, organic, and exchangeable Zn fractions in Zn0B0 were 40.48, 29.2, 27.1, 2.18, and 0.84%, respectively. These proportions changed to 37.24, 29.51, 26.9, 4.3, and 1.75%, in the Zn0B3 treatment. Maximum values of Zn uptake and grain yield were associated with the Zn2B3 treatment, showing increases (compared to the control) of 214 and 46%, respectively. The lowest ratio of PA/Zn was obtained in the Zn2B3 and Zn2B2 treatments, which exhibited reductions of 31.38 and 30.86%, respectively, when compared to the control.
Expression Cassette and Plasmid Construction for Yeast Surface Display in Saccharomyces Cerevisiae
Authors: Piraine Renan E A , Gonçalves Vitória S , Junior Alceu GS dos Santos , Cunha Rodrigo C , Albuquerque Pedro MM , Conrad Neida L , Leite Fabio
Published: February 2021

Objectives. Develop a Cell Surface Display system in S. cerevisiae, based on the construction of an expression cassette for pYES2 plasmid. Results. The construction of an expression cassette containing the α-factor signal peptide and the C-terminal portion of the α-agglutinin protein was made and its sequence inserted into a plasmid named pYES2/gDαAgglutinin, allowing cell surface display of bovine herpesvirus type 5 (BoHV-5) glycoprotein D (gD) on S. cerevisiae BY4741 strain. Recombinant protein expression was confirmed by dot blot, and indirect immunofluorescence using monoclonal anti-histidine antibodies and polyclonal antibodies from mice experimentally vaccinated with a recombinant gD. Conclusions. These results demonstrate that the approach and plasmid used represent not only an effective system for immobilizing proteins on the yeast cell surface, as well as a platform for immunobiologicals development.
Dielectric Behavior of Mechano-chemically Synthesized [(CH3NH3)3Bi2Br9]: A Lead Free Hybrid Perovskite
Authors: Pujaru Swagatalaxmi , Sadhukhan Priyabrata , Ghosh Basudev , Dhara Arup , Das Sachindranath
Published: February 2021

Lead free hybrid halide perovskite (CH3NH3)3Bi2Br9 has been successfully synthesized by mechano-chemical method. The microstructure analysis by Rietveld’s refinement method revealed that the crystal belongs to trigonal system with space group P3 ̅m1. The obtained microstructural parameters are well in agreement with the previously published data. Temperature-dependent ac conductivity, impedance spectroscopy, and complex dielectric properties have been investigated in detail. The negative temperature coefficient of resistance behaviour reveals the semiconducting nature of the materials. The complex impedance spectroscopy also supports the semiconducting nature of the sample with activation energy for conduction ~0.38 eV.
Combined Frameless Stereotactical Biopsy and Intraoperative Cerebral Angiography by 3D-Rotational Fluoroscopy with Intravenous Contrast Administration. A Feasibility Study.
Authors: Linsenmann Thomas , Cattaneo Andrea , März Alexander , Weiland Judith , Stetter Christian , Nickl Robert , Westermaier Thomas
Published: February 2021

Purpose: Mobile 3-dimensional fluoroscopes are available in a number of neurosurgical departments and can be used in combination with simple image post processing to depict cerebral vessels. In preparation of stereotactic surgery, preoperative Computed Tomography (CT) may be required for image fusion. Contrast CT may be of further advantage for image fusion as it regards the vessel anatomy in trajectory planning. Time-consuming in-hospital transports are necessary for this purpose. Mobile 3D-fluoroscopes may be used to generate a CT equal preoperative data set without an in-hospital transport. This study was performed to determine the feasibility and image quality of intraoperative 3-dimensional fluoroscopy with intravenous contrast administration.Methods: 6 patients were included in this feasibility study. Their heads were fixed in a radiolucent Mayfield clamp. A rotational fluoroscopy scan was performed with 50 mL iodine contrast agent. The image data sets were merged with the existing MRI images at a planning station and visually evaluated by two observer. The operation times were compared between the frame-based and frameless systems (“skin-to-skin” and “OR entry to exit”)Results: No adverse effects were observed. The entire procedure from fluoroscope positioning to the transfer to the planning station took 5 to 6 minutes with an image acquisition time of 24 seconds. In 5 of 6 cases, the fused imaging was able to reproduce the vascular anatomy accurately and in good quality. Both time end-points were significantly shorter compared to frame-based interventions.Conclusion: The images could easily be transferred to the planning and navigation system and were successfully merged with the MRI data set. The procedure can be completely integrated into the surgical workflow. Preoperative CT imaging or transport under anaesthesia may even be replaced by this technique in the future. Furthermore, hemorrhages can be successfully visualized intraoperatively and might prevent time delays in emergencies.
Close binary black hole in a radio-quiet quasar: a candidate of Nano-Hertz gravitational wave emitter
Authors: Feng Hai-Cheng , Liu Hong-Tao , Bai Jinming
Published: February 2021

Close supermassive binary black holes (SMBBHs) with separations less than about 0.1 parsec are expected to be Nano-Hertz gravitational wave sources. SMBBH systems should exhibit periodic variability. However, periodic variability in radio-loud quasars may be interpreted with the jet model. Here we report the detection of a robust periodic signal in the optical variability of the radio-quiet quasar PG 0923+201 with an observed period of 726.8±4.7 days, obtained from the sinusoid-like light curve of a temporal baseline of about 9 years. This periodicity is probably from a close SMBBH with a total mass of 109.3 solar masses and a separation of about 0.01 parsec, implying relativistic orbital speeds. Such a system has passed through the well-known “final parsec problem” of SMBBH systems, and the Nano-Hertz gravitational wave radiation becomes significant. The ratio of the separation between these two black holes to the broad-line region size is about 0.1. A close SMBBH is also suggested by this small ratio and the spectral properties of Balmer broad lines in this quasar. This radio-quiet quasar is a candidate emitter of Nano-Hertz gravitational waves at a frequency of about 30 Nano-Hertz.
Detection of EGFR Mutation of Pulmonary Adenocarcinoma in Sputum using Droplet Digital PCR
Authors: Isaka Tetsuya , Yokose Tomoyuki , Ito Hiroyuki , Nakayama Haruhiko , Miyagi Yohei , Saito Haruhiro , Masuda Munetaka
Published: February 2021

Background】It is still unclear whether epidermal growth factor receptor (EGFR) mutation of primary lung adenocarcinoma can be detected accurately on sputum samples. This study aimed to examine EGFR mutations of primary lung adenocarcinoma in sputum samples using droplet digital polymerase chain reaction (ddPCR) and compare it with an EGFR mutation in surgically resected lung cancer. 【Methods】Sputum was collected preoperatively from patients with primary lung cancer who were scheduled for complete resection of lung tumor at Kanagawa Cancer Center from September 2014 to May 2016. ddPCR was performed to detect EGFR exon 21 L858R point mutation (Ex21 mutation) and EGFR exon 19 deletion mutation (Ex19 mutation) in the sputum samples. The concordance of EGFR mutation status in sputum samples and tumors in surgically resected specimen was evaluated for each positive and negative cytology group.【Results】One hundred and eighteen patients with primary lung adenocarcinoma provided sputum samples. Sputum cytology was positive in 13 patients (11.0%). ddPCR detected two cases of Ex21 mutation and two cases of Ex19 mutation. Compared to surgically resected specimens, the sensitivity, specificity, and positive predictive value of EGFR mutation detection were 80.0%, 100%, and 92.3%, respectively. The sensitivity of EGFR mutation detection was 3.1% in sputum cytology negative cases. Logistic regression model analysis revealed that tumor size ≥ 29 mm determined using computed tomography (CT) was an independent potential predictive factor for positive sputum cytology (odds ratio = 10.6, 95% confidence interval: 1.85–61.0, p=0.008).【Conclusions】EGFR mutation of primary lung adenocarcinoma was accurately detected in sputum samples using ddPCR if the sputum cytology was positive. Sputum samples should be collected in patients with CT tumor size ≥ 29 mm for EGFR mutation analysis.
Distribution and correlations of school bully activities in a Central Indian district of Madhya Pradesh
Authors: Mishra Badrinarayan , Patidar Shivnarayan , Mishra Bidushi , Sinha Nidhi D , Mishra Gitisha
Published: February 2021

Background: Bullying at schools is a known but neglected phenomenon. The study of its prevalence and correlates are essential to curb this aberrant behavior for building a healthy society. Aim and objective: This cross-sectional evaluation was carried out to study the pattern through which bully activities manifests in students from 6th to 10th standards and find its positive and negative correlates.Methods: candidates’ selection was done through simple random and proportionate sampling methods to ensure equal presentation across the board i.e., urban vs rural, types of schools, gender and class(standard).Results: 480 participants were studied both from rural and urban high schools (6th – 10th standard) in equal proportion. An equal representation (33.3%) of participants were ensured from the three groups of schools studied i.e., Girls, Co-education, and Boys, across gender (50%) and class(standard) 20% from each. The age ranged from 10 years to 18 years with the mean age at 13.9 years and a standard deviation of 1.66. From the total studied population 52% were bystanders, and 48% were engaged in some form of bully activities (20% victim, 16% bully victim, and 13% bully). While both bully and victim scores had strong interconnect (strong positive correlation r = 0.259**, p - 0.000) their relation with prosocial and self-esteem scores were negative (p – 0.001). GHQ (General Health Questionnaire) score was not related to any of the above sub-scales. Conclusion: Bully related behavior was predominant in the studied population. From the results, it appears that measures directed at improving prosocial behaviors and self-esteem of pupils can act as effective counters to the reported empathetic activities.
Psychosocial interventions for reducing depression among the elderly in low and middle income countries: A Systematic Review Protocol
Authors: Amanyire Jordan Mutambi , Aheisibwe Irene , Rukundo Godfrey Zari
Published: February 2021

Background: According to the World Health Organization, depression is expected to be the largest contributor to the global disease burden by 2030. Depression is the most frequent cause of emotional distress and reduced quality of life among older people affecting over 12% of the individuals aged 65 or older, . Psychosocial interventions have been proven to be effective in the management of depression. Most of the available evidence is from high income settings, with paucity of information in low and middle income countries which carry the biggest burden of depression and other health challenges. In this systematic review, we will document evidence on psychosocial interventions that have been effective in treatment of depression among elderly people in low and middle income countries. Methods: The review will be conducted and reported in accordance to the preferred reporting items for systematic reviews and meta-analysis (PRISMA) statement. We will include journal articles that have documented the psychosocial interventions in the primary prevention of depressive symptoms in elderly people aged 60 or older. We will also include accessible grey literature about the topic. We will include articles that have documented the psychosocial interventions to address depression in elderly patients in low and middle income countries. We will search different search engines and data bases including PubMed, EMBASE, Psych-INFO, Cochrane Library. We will use a meta-analysis, should we find that there is no heterogeneity between included studies.Discussion: This protocol describes a planned systematic review of observational studies reporting psychosocial interventions in the management of depressive symptoms in elderly people aged 60 or older. We anticipate that once this review is complete and published, our findings will be of interest to the elderly with depressive symptoms, their families and caregivers, students, and other healthcare professionals, scientists and policy makers. Systematic review registration: This protocol will not be registered with PROSPERO International prospective register of systematic reviews since the system is no longer accepting new protocols.
Comparing the efficacy of two-week therapy with bismuth quadruple versus levofloxacin concomitant regimen for Helicobacter Pylori infection in Syrian patients. A randomized controlled trial.
Authors: Alhalabi Marouf Muhammad , Alassi Mohammed Waleed , Eddin Kamal Alaa , Cheha Khaled
Published: February 2021

Background: Antibiotic-resistant reduces the efficacy of conventional triple therapy for Helicobacter Pylori infections worldwide, lead to varying treatment protocols according to locations. The primary outcome of this research is to estimate the eradication rates of modified bismuth quadruple versus modified levofloxacin concomitant as empirical first-line treatment by intention to treat analysis (ITT) and per-protocol analysis (PPA) in a referral hospital in Syria.Settings and Design: an open‑label parallel blind randomized controlled trial.Methods: We randomly assigned seventy-eight naïve who tested positive for Helicobacter Pylori gastric infection, with a 1:1 ratio to (B-group) which receive (bismuth subsalicylate 524 mg four times daily, doxycycline 100 mg, tinidazole 500 mg, and esomeprazole 20 mg, each twice per day for two weeks), or (L-group) which receive (levofloxacin 500 mg daily, tinidazole 500 mg, amoxicillin 1000 mg, and esomeprazole 20 mg each twice per day for two weeks). We confirmed Helicobacter Pylori eradication by stool antigen test at eight weeks. Results: Thirty-nine patients were allocated in each group. In the B- group, thirty-eight patients completed the follow-up, thirty patients were cured. While in the L-group, thirty-nine completed the follow-up, thirty-two patients were cured. According to ITT, the eradication rates were 76.92%, and 82.05%, for the B-group and L-group respectively. Odds ratio with 95% confidence interval was 1.371 [0.454-4.146]. According to PPA, the eradication rates were 78.9 %, and 82.1% for the B-group and L-groups respectively. The odds ratio with 95% confidence interval was 1.219 [0.394-3.774]. We didn’t report serious adverse effects. Conclusions:The eradication rates in both therapy regimes were fair. Further trials are intended to help select the right first-line treatment for Helicobacter-Pylori Infection in the Syrian population.Trial registration: We register this study as a standard randomized clinical trial (Clinicaltrial.gov, identifier‑NCT04348786, date:29-January-2020, https://clinicaltrials.gov/ct2/show/NCT04348786).
Rückzug einer Volksinitiative nach aufgehobener Volksabstimmung
Authors: Seferovic Goran
Published: February 2021

Im Nachgang zur Aufhebung der Volksabstimmung über die Volksinitiative «Für Ehe und Familie — gegen die Heiratsstrafe» (BGE 145 I 207) hatte das Bundesgericht zu entscheiden, ob das Initiativkomitee erneut Gelegenheit erhalten sollte, seine Initiative zurückzuziehen, oder ob über die Initiative zwingend wieder abzustimmen sei. Mit einer weitgehend überzeugenden Begründung weist das Bundesgericht die Beschwerde ab und spricht sich dafür aus, dem Initiativkomitee den Rückzug der Initiative zu gestatten. Dass das Gericht die Beschwerde zulässt, ist mit Blick auf die Rechtsweggarantie und den breiten Anwendungsbereich der Beschwerde in Stimmrechtssachen zu begrüssen. Das Urteil lässt dabei aber eine Reihe von prozessualen Fragen ungeklärt, was aus Sicht der Praxis der Stimmrechtsbeschwerde zu bedauern ist. So hätte das Bundesgericht zumindest klarstellen sollen, dass die Rückzugserklärung des Initiativkomitees selbst Anfechtungsobjekt der Beschwerde bildet und nicht die Bekanntmachung des Rückzugs durch die Bundeskanzlei.
Tax aggressiveness and CEO overconfidence in the stock market: Evidence from Brazil
Authors: Carrer Giovana , Slavov Tiago
Published: February 2021

This study examines the association between tax aggressiveness and overconfidence in 277 Brazilian stock market listed companies from 2010 to 2017, with the supposition (based on optimal capital ownership structure theory) that the greater a manager’s overconfidence, the more aggressive the company’s tax decisions. Overconfidence is measured in an innovative way in which normalizing excess acquisitions and excess investments using the company’s market value and then combining these two variables with indebtedness to capture, more directly, the possible effects of overconfidence on the corporation’s operations. Tax aggressiveness is computed using a tax burden on earnings and value-added. The variables included in the model were obtained from data contained in the selected companies’ financial statements. Data analysis was performed by multiple linear regression. The parameters used combined and fixed effects methods to identify an association between tax aggressiveness and overconfidence. Data related to corporate governance, CEO’s characteristics, and capital concentration were used as control variables. The study’s main finding does not show any significant relationship between fiscal aggressiveness and overconfidence; however, they did show a significant association with tax aggressiveness, the company’s size, the return on shares, and the education level of the CEO. An interesting finding of the robustness tests is the stationarity of tax aggressiveness, which could partially explain the non-significance of the main finding.
Molecular and Metabolic Imaging of Castration-Resistant Prostate Cancer: State of Art and Future Prospects
Authors: Filippi Luca , Chiaravalloti Agostino , Basile Pietro , Schillaci Orazio , Bagni Oreste
Published: February 2021

:

Prostate cancer (PCa) represents the most common tumor in male and one of the most relevant causes of death in Western countries. Androgen deprivation therapy (ADT) constitutes a widely used approach in advanced PCa. When PCa progresses in spite of ADT and castrate levels of testosterone, the severe clinical condition termed as metastatic castration-resistant prostate cancer (mCRPC) takes place. The only approach to mCRPC has been represented by chemotherapy with taxanes for many years. Nevertheless, recently introduced treatments such as 2nd generation antiandrogens (i.e. enzalutamide and abiraterone), cell immunotherapy with sipuleucel-T or targeted alpha therapy with 223Ra-dichloride, have dramatically changed mCRPC prognosis. These novel therapies call for an unmet need for imaging biomarkers suitable for patients’ pre-treatment stratification and response assessment. In this scenario, nuclear medicine can provide several metabolic and molecular probes for investigating pathological processes at a cellular and sub-cellular level. The aim of this paper is to review the most relevant findings of the literature published to date on this topic, giving particular emphasis to the pros and cons of each tracer and also covering future prospects for defining personalized therapeutic approaches.
Iron Nanoparticle Production by the Method of Electric Explosion of Wire
Authors: Gryaznova Elena , Pustovalov Alexey
Published: February 2021

Background:

The widespread use of iron nanopowders is connected with a wide range of
characteristics such as size, magnetic characteristics and high surface area and that is why many researches
present its different applications in the literature.

Objective:

The work studies the influence of the conditions for the iron wire electrical explosion on the
course of the explosion process and the dispersed composition of the resulting metal nanopowder.

Method:

Experiments on the electrical explosion of iron wires were carried out in the laboratory setup
with the different initial conditions of the electrical explosion of the iron wire.

Results:

The influence of the initial wire electrical explosion conditions on the explosion regime, the
specific energy input into the conductor, and the specific energy released in the arc stage of discharge
are definitely determined. The empirical equations for the calculation of the initial wire electrical explosion
conditions for providing the critical explosion in the argon medium at a pressure of 2·105 Pa, were
defined. It has been established that for the synthesis of iron nanopowders with a narrow particle size
distribution, it is preferable to use modes with a high level of the energy released in the arc stage of the
discharge.

Conclusion:

It was found that disabling the arc stage of the discharge during EEW leads to the decrease
of the average surface particle size by 50%.
Rancang Bangun Role Playing Game Timun Mas Dan Raksasa Dengan Menggunakan Metode Game Development Life Cycle
Authors: Wahono Wahyu , Cahyono Eko Budi , Hariyady Hariyady
Published: February 2021

Penelitian ini bertujuan untuk membangun Game Role-Playing Game (RPG) berdasarkan cerita rakyat Timun Mas dan Raksasa. Pembangunan Game ini untuk memvisualisasikan cerita rakyat Timun Mas dan Raksasa. Cerita pada game berdasarkan cerita rakyat Timun Mas dan Raksasa yang berasal dari wilayah Jawa Tengah. Metode penelitian yang dipakai pada pembuatan game RPG ini yakni Game Development dimana tahapan penelitiannya terdiri dari pitch, pre-production, main production, alpha, beta, dan master. Pada penelitan ini berhasil membangun game RPG Timun Emas yang bersumber dari cerita rakyat Indonesia. Dengan terbangunnya game RPG ini diharapkan akan menarik minat anak-anak untuk memainkannya, terlebih lagi game ini dapat menjadi media penyampai informasi tentang cerita rakyat bagi anak-anak Indonesia pada umumnya.
Membangun SMS Gateway Info Kesiswaan Pondok Pesantren Putra Al-Ittihad Al-Islami Madura
Authors: Ishlakhuddin Fauzan , Cahyono Eko Budi , Nuryasin Ilyas
Published: February 2021

Penelitian  ini  bertujuan  untuk  membuat  sebuah  aplikasi  SMS  Gateway  yang  dapat menyebarkan info kesiswaan kepada wali santri dengan cepat, mudah dan menjangkau semua kalangan  melalui  SMS.  Aplikasi  ini  akan  melakukan  SMS  secara  otomatis  kepada  wali  santri mengenai   info   pelanggaran,   nilai,   keuangan   dan   absensi   santri.   Aplikasi   ini   dibangun menggunakan framework  codeigniter  untuk  mempermudah  dan  mempercepat  pengerjaan dengan   bahasa   pemrograman   PHP.   Aplikasi   ini   juga   memanfaatkan   GAMMU   sebagai penghubung  antara  aplikasi  dengan  modem.  Untuk  mempercepat  pengiriman  SMS  dengan jumlah  yang  banyak,  aplikasi  inimemanfaatkan  2  modem  yang  akan  secara  bergantian mengirimkan  pesan  yang  ada  pada  antrian.  Dari  hasil  ujicoba  yang  dilakukan  dapat  diambil kesimpulan bahwa aplikasi ini mampu mempermudah dan mempercepat pihak pesantren dalam menyebarkan info kesiswaan melalui SMS juga dapat menjangkau hampir semua kalangan wali santri.
Prediksi Harga Saham Menggunakan Sentimen Pilkada DKI Jakarta 2017 Dengan Algoritma Support Vector Machine
Authors: Fadliansyah Muhammad , Basuki Setio , Azhar Yufis
Published: February 2021

Twitter merupakan salah satu sosial media yang paling banyak dipakai di Indonesia, tidak hanya sebagai sarana berbagi informasi terkait hal – hal pribadi tetapi juga bisa berupa opini terhadap suatu topik. Tidak hanya sebagai pusat infromasi, twitter juga bisa digunakan sebagai pusat data berupa teks. Pilkada DKI Jakarta 2017 merupakan salah satu topik yang menarik untuk di bahas. Tidak hanya sebagai penentu kepemimpinan Jakarta untuk 5 tahun kedepan, tetapi karena pengaruh yang dimilikinya terhadap beberapa sektor di Indoensia. Tweet yang membahas topik Pilkada DKI Jakarta 2017 bisa diolah untuk mendapatkan informasi yang berguna, misalnya sentimen yang terjadi selama peristiwa politik ini terjadi. Sentimen yang didapat bisa digunakan dalam prediksi harga saham selama masa Pilkada. Untuk bisa mendapatkan sentimen dari data teks dari twitter, sentiment anaylsis digunakan untuk mengekstrak informasi dari tweet yang sudah dikumpulkan. Untuk melakukan sentiment analysis, algoritma support vector machine dipakai untuk mengklasifikasikan tweet kedalam target kelas. Hasil dari klasifikasi sentimen digunakan sebagai salah satu pembobot dalam regresi linier untuk memprediksi harga saham. Hasil dari pengujian menunjukkan bahwa penggunaan sentimen Pilkada DKI Jakarta 2017 untuk memprediksi harga saham cukup baik. Dimana nilai RMSE yang didapat oleh masing-masing saham bervariasi karena saham-saham yang dipilih berasal dari sektor yang berbeda. BBRI 58.974, SRTG 101.188, WIKA 52.042, ADHI 93.420 dan APLN 17.342.
Sistem Rekomendasi Wisata Kuliner Kota Malang Dengan Metode Collaborative Filtering Dan Location Based Filtering
Authors: Rakasiwi Rendra Sandi Rendra
Published: February 2021

Wisata merupakan sebuah identitas bagi setiap kota yang memiliki nilai tersendiri untuk di kunjungi oleh wisatawan. Pada umumya yang sering di jumpai oleh wisatawan adalah wisata alam dan wisata kuliner. Dalam penelitian ini akan membahas penelitian tentang wisata kuliner yang ada di Kota Malang. Dimana terdapat permasalahan wisatawan mengalami kebingungan dalam menentukan tempat kuliner yang sesuai dengan keinginan wisatawan tersebut. Maka dari itu dalam penelitian ini, metode collaborative filtering dan location based filtering akan digunakan untuk menentukan rekomendasi wisata kuliner. Tujuan dari penelitian ini adalah penggunaan metode collaborative filtering yang di bagi menjadi 2 tahap yaitu tahap user based untuk menentukan tempat kuliner berdasarkan kriteria karakter setiap pengguna yang memiliki kesamaan dan tahap item based untuk menentukan tempat kuliner berdasarkan nilai rating tiap tempat kuliner yang memiliki kesamaan. Selanjutnya untuk metode location based filtering digunakan untuk menyaring tempat kuliner yang memiliki lokasi terdekat dengan wisatawan. Untuk menyamakan karakter antar pengguna begitu juga dengan nilai rating tempat kuliner akan digunakan persamaan adjusted cosine similarity. Untuk pengujian sendiri akan digunakan metode black box, dimana mencoba satu persatu fitur yang ada.
Perbandingan Metode Klasifikasi Berita Hoaks Berbahasa Indonesia Berbasis Pembelajaran Mesin
Authors: Athaillah Muhammad
Published: February 2021

Klasifiaksi berita hoaks merupakan salah satu aplikasi kategorisasi teks. Berita hoaks harus diklasifikasikan karena berita hoaks dapat mempengaruhi tindakan dan pola pikir pembaca. Dalam proses klasifikasi pada penelitian ini menggunakan beberapa tahapan yaitu praproses, ekstraksi fitur, seleksi fitur dan klasifikasi. Penelitian ini bertujuan membandingkan dua algoritma yaitu algoritma Naïve Bayes dan Multinomial Naïve Bayes, manakah dari kedua algoritma tersebut yang lebih efektif dalam mengklasifikasikan berita hoaks. Data yang digunakan dalam penelitian ini berasal dari www.trunbackhoax.id untuk data berita hoaks sebanyak 100 artikel dan data berita non-hoaks berasal dari kompas.com, detik.com berjumlah 100 artikel. Data latih berjumlah 140 artikel dan data uji berjumlah 60 artikel. Hasil perbandingan algoritma Naïve Bayes memiliki nilai F1-score sebesar 0,93 dan nilai F1-score Multinomial Naïve Bayes sebesar 0,92.
Multiaxial Non-proportional Low Cycle Fatigue Properties of HIPped A319 Cast Aluminum Alloy
Authors: Ge Bin , Liu Xiaoshan , He Guoqiu , Le Peiwen , Zhou Zhiqiang , Pan Jiaqi , Huang Ziao , Li Jingquan , Wang Qigui
Published: February 2021

This paper describes a microstructure-based multiaxial non-proportional
fatigue life prediction model with maximum shear strain and
non-proportionality as damage parameters applied to A319 alloy. The
materials made with different casting cooling rates and Sr modification
are characterized and quantified in terms of secondary dendrite arm
spacing (SDAS), size and aspect ratio of eutectic Si particles.
Multiaxial non-proportional fatigue tests have been performed on six
groups of A319 alloys to systematically analyze the effect of
microstructure and loading path on the fatigue properties of Al-Si cast
alloy. The first part of the paper is focused on microstructure
quantitative characterization to determine the influence of different
casting conditions, followed by stress response behavior and fatigue
fracture analysis. Finally, quantitative relationship between six
fatigue life parameters and microstructure characteristics is
established and a new fatigue life prediction model is proposed to
predict fatigue life of Al-Si alloy under multiaxial non-proportional
loading condition.
Effects of different interlayers on the microstructure and properties of Mg/Cu dissimilar alloy welded joints
Authors: Yu Banglong , Dai Jun , Ruan Qingdong , Chu Paul K. , Lu Wangzhang , Yang Yao , Qiao Jian
Published: February 2021

AZ31B Mg alloy and Cu (T2) were combined with different interlayers and laser pulse-welded in the form of lap joints. The microstructure and properties of Mg/Cu dissimilar alloy welded joints of different interlayer materials were studied. The results indicated that the morphology of the welded joint of different interlayer materials were unique. There were cracks in the welded joints of Ti foil and Sn foil. The best welding profile was observed from the Zn foil middle layer, and Cu2Ti and MgZn were formed in Ti and Zn foil welded joints, respectively. The msc marc software was used to simulate the welding temperature and stress of different welded joints. The average thermal stress on the Cu surface was significantly reduced by the different interlayers. The corrosion potential (Ecorr) of the Ti foil welded joint was −0.9111 V, and the corrosion current densities (Icorr) with the Ti foil, Zn foil, and noninterlayer were 32.612, 332.551, and 538.473 μA/cm2, respectively. The corrosion resistance of the welding joints by the Ti foil was the best. The most favorable interlayer was Zn foil, and the shear strength was 48.15 MPa, which was 161% higher than that of the without interlayer welded Mg/Cu joint.
Evaluasi Kepatuhan Pajak Berdasarkan Perilaku Data Keuangan dan Non Keuangan (Studi Kasus pada KPP Jakarta)
Authors: Maulana Muhammad Bayu , Wirjolukito Aruna
Published: February 2021

The purpose of this research is to evaluate tax compliance based on the behavior of taxpayers' financial and non-financial data. This research is expected to be useful as material for evaluating the level of tax compliance of taxpayers. This study uses a case study method (single case) and uses a mixed method. Descriptive analysis is used to analyze data from the research object in the form of a single case unit analysis. The results of this study indicate the perceived behavior control of taxpayers that shows low tax compliance behavior. The combination of analysis of financial and non-financial data from taxpayers produces a useful evaluation in determining the level of tax compliance. Based on this, the low achievement of tax revenue realization and high tax audit performance is directly influenced by the low tax compliance behavior of taxpayers.

Keywords: Tax Compliance; Behavior; Financial Data; Non-Financial Data.
MAGNETIC AEROSPACE ENGINE (FULL VERSION)
Authors: Berhulov Anton
Published: February 2021

Subject of interstellar flights remains actual taking into account limitedness of the terrestrial resources, overpopulation of the planet, and demographic, sociopolitical and ecological problems at the planet. A constructive solution is submitted of the construction of a spacecraft moving with acceleration resting upon electromagnetic fields of the Solar system and the Galaxy. Calculation of the current intensity within the circuit and charge value at the object's useful surface necessary for the achievement of acceleration equal to 1g at arbitrary direction in the space is conducted. A method of levitation in magnetic fields of planets (superposition of magnetic fields of a star and a planet) and interplanetary space (superposition of magnetic fields of galaxies) without using the Coulomb force is proposed.
ИННОВАЦИОННАЯ ПАРАДИГМА БЮДЖЕТНО-НАЛОГОВОЙ СИСТЕМЫ ФОРМИРОВАНИЯ ДОХОДОВ БЮДЖЕТА БЮДЖЕТНОЙ СИСТЕМЫ СТРАНЫ: АДАПТАЦИЯ МОДЕЛЕЙ И АЛГОРИТМА К РЕЗУЛЬТАТАМ ЭКСПЕРИМЕНТАЛЬНЫХ РАСЧЕТОВ
Authors: Павлов Вячеслав Иванович , Зоидов Хуршеджон Кобилджонович
Published: February 2021

Предмет. В статье рассматриваются теоретические основы формирования доходов бюджета бюджетной системы страны с использованием инновационной парадигмы бюджетно-налоговой системы, синтезирующей в себе классические и неоклассические экономические школы применительно к дальнейшей трансформации формулы стоимости К. Маркса, учитывающей дополнение А. Маршалла о том, что в издержки производства включается только чрезмерный износ основных доходов. Цель работы. Отразить предлагаемые новации в экономической теории, синтезирующие в себе важнейшие аспекты классической и неоклассической экономических школ, которые могут поставить Россию в авангарде мировой цивилизации, сделать ее экономику самой открытой в мире и привлекательной для инвестиций в виде инновационных технологий. Методология исследования. В процессе исследования использованы методы эволюционно-институциональной теории, эконометрического моделирования и аналитической оценки. Результаты исследования. Экспериментальные расчеты доходов бюджета бюджетной системы страны с использованием моделей и алгоритма этой системы подтверждают ее преимущество перед действующей в настоящее время налоговой системой. Выводы. В связи с постепенным развитием экономического кризиса, вызванного как внешними обстоятельствами, так и внутренними структурными проблемами, особую актуальность принимает проблема поиска механизмов эффективного регулирования совершенствования инновационной парадигмы бюджетно-налоговой системы формирования доходов бюджета бюджетной системы страны. Область применения результатов. Результаты исследования могут быть использованы органами власти России для ликвидации существующих проблем в области адаптации моделей и алгоритма с результатами экспериментальных расчетов инновационной парадигмы бюджетно-налоговой системы формирования доходов бюджета бюджетной системы страны. Разработанные предложения и механизмы эффективного регулирования совершенствования инновационной парадигмы бюджетно-налоговой системы формирования доходов бюджета бюджетной системы России в условиях нестабильности могут быть востребованы для сохранения и усиления конкурентных преимуществ страны в целом.
АНАЛИЗ РАЗВИТИЯ ГОСУДАРСТВЕННОЙ РЕГИОНАЛЬНОЙ ПОЛИТИКИ РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: Исакова Гулизар Казбековна
Published: February 2021

Предметом работы является рассмотрение проблемы региональной экономики как важнейшей части региональной политики. Целью работы является рассмотреть способы повышения эффективности государственной региональной политики в Российской Федерации. Методология проведения работы – основывается на необходимости демонстрирования значения, а также на раскрытии содержания и методов ведения региональной политики. Результаты работы – нами было приведено конкретное определение такого термина, как государственная региональная политика. Также в данной работе рассмотрены некоторые аспекты данной политики. Область применения результатов – выработанные в ходе исследования предложения могут быть использованы для устранения возможных проблем региональной политики государства. Выводы: практическое применение руководящих принципов по совершенствованию региональной политики Российской Федерации будет способствовать устойчивому экономическому росту, компенсирует межрегиональные различия в наличии социальной инфраструктуры, инвестиционных возможностях, а также поможет снизить политическую напряженность.
ПРОБЛЕМЫ И ПУТИ СОВЕРШЕНСТВОВАНИЯ СИСТЕМЫ ГОСУДАРСТВЕННО-ПРАВОВОГО РЕГУЛИРОВАНИЯ ИНВЕСТИЦИОННОЙ СФЕРЫ РЕГИОНА
Authors: Арсланов Шамиль Джавадович
Published: February 2021

Целью настоящего исследования является попытка определить основные проблемы и направления совершенствования государственно-правового регулирования инвестиционной сферы региона, выявить факторы и проблемы, тормозящие ее развитие. Методы исследования. Определены основные проблемы развития инвестиционной сферы и направления совершенствования ее государственно-правового регулирования. Рассмотрены все субъекты инвестиционной деятельности с выделением их специфики на основе осуществления их экономической деятельности. Проанализированы основные тенденции правового регулирования инвестиционной деятельности. Область применения результатов. Результаты исследования могут быть применены в ходе формирования и реализации как региональной инвестиционной политики в целом, так и ее структурных элементов в отдельности. Результаты. Установлена необходимость формирования механизмов государственной поддержки институциональных инвесторов. Предложены направления развития государственно-правового регулирования инвестиционной сферы региона. Выводы. Регионам СКФО необходимо соответствовать современным трендам развития инвестиционной деятельности, для чего, как показывает практика, необходим своевременный и детализированный комплекс НПА, позволяющий запустить механизмы формирования и развития цифровизации в инвестиционной сфере. Необходимо также исключить «лобби» государственных органов в процессе формирования «цифровых» инвестиционных проектов путем введения ответственности за несоблюдение принципов и положений действующего инвестиционного законодательства.