bluuebunny/crossref_metadata_2025 huggingface dataset:
Failure Analysis of a Spoon Broken by a Parapsychic Person
Authors: Shaw W.J.D.
Published: May 2019

A spoon that was twisted and broken by a person claiming to possess parapsychic powers was submitted for failure analysis. Exemplar tests were conducted on material taken from the bowl region of the same spoon. In addition, tests on other unbroken samples of spoons were evaluated in order to establish both macroscopic and microscopic comparative behavior. These controlled tests produced known failure mechanisms and their respective fracture morphology in this material. A direct comparison could then be made with the unknown failure. The paper identifies a method of analysis that should be applied when analyzing failures of unknown origin.
Fracture of a Bone Drill
Authors: Naumann Friedrich Karl , Spies Ferdinand
Published: May 2019

A stainless tool steel bone drill broke during an operation on a patient and was examined. It showed two fatigue fractures, one of which had started from a sharp-edged, coarsely milled slot (fracture A1), and the other from a point on the outer sheath surface which was not subjected to particularly high stresses (fracture A2). Fatigue fracture A1 resulted from the stress concentration built up at this point as a result of the sharp edges and the coarse machining grooves. The remains of a number, which had been inscribed with an electrical engraving tool for identification purposes, were found at the point of origin of fracture A2. The material had been heated to the melting point during the engraving of the number, and multiple cracking occurred during cooling. One of these cracks led to the development of fatigue fracture A2.
Damage to Tool Joints in Hydrogen Sulfide-Carrying Natural Gas Drilling Operation
Authors: Naumann Friedrich Karl , Spies Ferdinand
Published: May 2019

During natural gas drilling in the EMS region in 1956, considerable numbers of longitudinal cracks and transverse fractures occurred in the connecting pieces of the bore rods. The connectors were screwed onto the rods by means of a fine thread and tightly joined with it by shrinkage at 530 deg C. The connectors were made of SAE 4140 Cr-Mo steel. The material for the rod pipes was Fe-0.4C-1Mn steel. Structural stresses played a role in the cracking. Iron sulfide formed on the fracture planes and flake-like stress cracks occurred in the steel. The hydrogen sulfide content of the gas was the cause of damage. Hydrogen liberated by reaction with the iron caused the formation of iron sulfide after penetration of the steel, which had an explosive effect during molecular separation under high pressure. This in turn caused the crack formation in conjunction with the external and residual stresses.
Role of Microstructure in Sucker Rod String Failures in Oil Well Production
Authors: Benhaddad Sofiane , Lee Glen
Published: May 2019

Sucker-rod pumps are operating in very aggressive environments in oil well production. The combined effect of a corrosive environment and significant mechanical loads contribute to frequent cases of failure of the rod string during operation. Standards and recommendations have been developed to control and avoid those failures. This study presents various failure cases of sucker rods in different applications. The heat treatment of the steel material and the resulting microstructure are an important factor in the behavior of the sucker rod. A spheroidized microstructure presents a weaker resistance to corrosion affecting the rod life. Non-metallic inclusions are a pitting preferential site leading to fatigue crack initiation. Heterogeneous microstructure as banded martensite and ferrite/pearlite decreases the ductility of the material affecting the fatigue propagation resistance.
Failure of a Large Oil Storage Tank
Authors: Le May I. , Bagnall C.
Published: May 2019

A four-million gallon capacity (15,142 cu m) oil storage tank ruptured upon filling after re-erection near West Elizabeth, PA on 2 Jan 1988. The tank shell split vertically with failure originating at a flaw existing prior to the reconstruction. Brittle fracture occurred both up and down from the defect when the stress induced by filling reached a critical value for the steel, which had poor toughness properties. This steel had been used in the original construction of a tank in Ohio more than 40 years previously. The defect at which brittle fracture originated in the tank shell showed evidence of burning from a torch. This tank failure was the catalyst for the introduction of new rules concerning the inspection and assessment of older storage tanks.
Resultados perinatales del recién nacido con Apgar bajo en el Hospital Hipólito Unanue de Tacna, 2002–2016
Authors: Acero Viera Oliver , Ticona Rendon Manuel , Huanco Apaza Diana
Published: May 2019

Introducción. El Apgar bajo al minuto de nacimiento es un problema clínico que contribuye a la morbimortalidad neonatal. Objetivo. Conocer los resultados perinatales adversos del recién nacido con Apgar bajo. Diseño. Estudio retrospectivo, analítico, de casos y controles. Institución. Hospital Hipólito Unanue de Tacna, Perú. Participantes. Se estudió 2 176 recién nacidos vivos durante los años 2002 a 2016, con Apgar al minuto menor de 7, de embarazo único, comparados con 4 352 nacidos vivos con Apgar 7 a 10 seleccionados por muestreo aleatorio simple. Se utilizó la base de datos del sistema informático perinatal SIP2000. Principales medidas de resultados. Frecuencias absolutas y relativas, promedios, desviación estándar, análisis bivariado, odds ratio con intervalos de confianza al 95%. Resultados. La frecuencia de recién nacidos con Apgar bajo fue 4,1 por 100 nacidos vivos. Se asociaron al Apgar bajo los recién nacidos de sexo masculino, prematuros, peso bajo, pequeños y grandes para la edad gestacional y nacidos por cesárea. Los resultados perinatales adversos fueron riesgo de morbilidad (OR=5,8), mortalidad neonatal (OR=41,1), infección perinatal (OR=9,4), síndrome de dificultad respiratoria (OR=7,6), malformaciones congénitas (OR=7), traumatismo al nacer (OR=5,4) e hiperbilirrubinemia (OR=4,9). Los fallecidos fueron 79,4% prematuros y 78,7% de peso bajo. Conclusión. El recién nacido con Apgar bajo al minuto en el hospital Hipólito Unanue de Tacna tiene riesgo alto de morbilidad y mortalidad neonatal.
Restricción de crecimiento intrauterina selectiva tipo III, en gemelos monocoriales: serie de casos y revisión de la literatura
Authors: Lacunza Paredes Rommel Omar , Vera Del Carpio Carlos , Paucarchuco Tapara Arturo
Published: May 2019

Se presenta cuatro casos de gestaciones dobles monocoriales afectadas con restricción selectiva de crecimiento de tipo III, con énfasis en las características ecográficas (evaluación de la diástole intermitente reversa de la arteria umbilical y la anastomosis superficial arterio-arterial), evolución durante la gestación y seguimiento hasta el mes de vida.
Síndrome de banda amniótica: reporte de 18 casos
Authors: Romero Rojas Nery , Moscoso Gonzalo , Rosas Luz , Vicuña Milagros
Published: May 2019

El síndrome de banda amniótica es una entidad congénita fetal que consiste en la presencia de bandas fibrosas y anomalías disruptivas muy variadas y variables en presentación y complejidad, algunas incompatibles con la vida. Se presenta 18 casos de síndrome de banda amniótica con estudio anatomopatológico de los fetos o neonatos y revisión de la historia clínica materna. Se encontró 5 neonatos y 13 fetos, 9 de ellos de sexo masculino y 9 de sexo femenino. El menor pesó 19 g y el mayor fue un neonato de 3 680 g; 9 fetos pesaron < 110 g. Las lesiones encontradas estuvieron en dedos 13, en labio 6, en cara 6, en cráneo 5, en abdomen 2, en cordón umbilical 8, en pared abdominal 2, en extremidades 5. Se encontró malformaciones asociadas en 8 casos, de tipo renal, cardiaca, pulmonar, digestiva, musculoesquelética, neurológica y del cordón umbilical. Las del cordón umbilical fueron arteria única, cordón corto, inserción velamentosa y circular de cordón. En relación a la madre, la edad fue entre 17 y 41 años, promedio 26 años; 11 casos ocurrieron en primigestas; de las 7 multigestas, 5 tuvieron abortos previos. No se encontró otros antecedentes familiares o patológicos de importancia. Se concluye que el síndrome de banda amniótica produce en los fetos anomalías polimorfas y asimétricas que es necesario diferenciarlas de aquellas de tipo cromosómico o genético. Así mismo, existe la posibilidad de una intervención intraútero que elimine las bandas fibrosas diagnosticadas ecográficamente a temprana edad gestacional.
Derivación toracoamniótica en hidrotórax fetal: reporte de un caso
Authors: Huertas Tacchino Erasmo , Hijar Sifuentes Adelita , Elias Estrada José Carlos , Huerta Sáenz Igor , Florez Mendoza Armando
Published: May 2019

Presentamos un caso de hidrotórax masivo unilateral diagnosticado a las 18 semanas de gestación en un feto con cariotipo normal. El feto fue afectado severamente por hydrops y bradicardia desde las 24 semanas. Inicialmente realizamos una pleurodesis, pero debido al empeoramiento del hidrotórax que evolucionó a hidropesía, procedimos con la inserción de una derivación toracoamniótica transplacentaria. La mejoría fue evidente una semana después del procedimiento, seguido por la resolución del hidrotórax durante el resto del embarazo. Después de una cesárea a las 37 semanas, el neonato requirió una estancia prolongada en la UCIN. Fue dado de alta a los 2 meses de edad y se ha mantenido estable hasta el momento actual.
Ascitis fetal: a propósito de un caso y revisión de la literatura
Authors: H. Novoa Rommy , Araujo Kerly , Mercado Jorge , Castillo Walter , Ingar Jaime , Ventura Laveriano Walter R. , Huertas Tachino Erasmo , Zárate Girao Mario I. , Limay Ríos Antonio , Sugajara Rosario Ricardo R.
Published: May 2019

La ascitis fetal se define como la presencia de líquido intraperitoneal que puede ser parte de un hidrops generalizado o aislado. La mortalidad de la ascitis no inmune, tanto fetal como neonatal, es aproximadamente 60%. Se presenta un caso de ascitis fetal no asociada a hidrops y se revisa la patogenia, clínica y el enfoque diagnóstico y tratamiento de esta condición fetal y neonatal.
La importancia del asesoramiento genético para el diagnóstico genético preimplantacional de aneuploidías (PGT-A)
Authors: Sessarego Tabja Silvana
Published: May 2019

El desarrollo de las nuevas tecnologías genómicas ha potenciado la influencia de la genética en todos los campos de la medicina, en donde la medicina reproductiva no es la excepción. La frecuente introducción de nuevas pruebas genéticas en la práctica clínica diaria, junto con la complejidad de la información genética y su potencial carga psicológica, hacen indispensable el asesoramiento genético especializado. En este contexto, el diagnóstico genético preimplantacional para aneuploidías (PGT-A) se ha convertido en un procedimiento casi de rutina en los tratamientos de reproducción asistida. Sin embargo, en el Perú, en la gran mayoría de casos los pacientes no reciben el asesoramiento genético correspondiente o este no es el adecuado, que no permite una toma de decisiones informada.
Embarazo abdominal postérmino. Reporte de un caso
Authors: Ramírez Cabrera Juan Orestes , Zapata Díaz Betsy Micol , Campos Siccha Gerardo Jimmy , Mejía Cabrera Fiorella Suhayl , Mendoza Solórzano Patricia Roxana
Published: May 2019

El embarazo ectópico abdominal representa una situación dramática para la salud de la mujer. Al ser una patología poco frecuente, resulta al ginecólogo una prueba difícil para habilidad diagnóstica, capacidad de decisión y técnica quirúrgica, incluso para el más experto. Se presenta un caso de embarazo ectópico abdominal postérmino, que llegó con óbito fetal dentro de la bolsa corioamniótica y la placenta implantada sobre vísceras abdominales. Se describe los datos clínicos, hallazgos operatorios y el manejo conservador de la placenta retenida, y se hace una revisión bibliográfica del tema.
Microsomía hemifacial fetal: entendiendo el espectro fenotípico en el reporte de un caso
Authors: Lacunza Paredes Rommel Omar , Farfán Cárdenas Roxana
Published: May 2019

La macrosomía hemifacial involucra un amplio espectro de malformaciones faciales de diversa severidad. El diagnóstico prenatal es hecho excepcionalmente y habitualmente está relacionado a casos severos o con asociación a otras malformaciones corporales. Presentamos un caso de macrosomía hemifacial severa con malformaciones gastrointestinales múltiples y cerebrales.
ARICILIK İŞLETMELERİNDE MEVCUT DURUM TEMEL SORUNLAR VE ÇÖZÜM ÖNERİLERİ ÜZERİNE BİR ARAŞTIRMA (BİNGÖL İLİ ÖRNEĞİ)
Authors: Karakaya Ersin
Published: May 2019

Bu çalışma, Bingöl ilinde arıcılık yapan
işletmelerinin yapısal durumunu, temel sorunlarını ve çözüm önerilerini
belirlemek amacıyla yapılmıştır. Kovan başına bal verimini etkileyen
faktörlerin belirlenmesinde regresyon analizi kullanılmıştır. Oransal örnekleme
yöntemiyle 87 adet işletmeyle anket yapılmıştır.

Araştırma bulgularına göre, yetiştiricilerin
yaş ortalaması 47.3, ortalama arıcılık yapma süresi 18.1 yıl, üretici başına
düşen mevcut kovan sayıları ortalaması 133.6 adet ve koloni başına bal verimi
ortalaması ise 11.1 kg olarak belirlenmiştir. Yapılan analiz sonucunda
yetiştiricilerin büyük bir kısmının (%84) gezginci arıcılık yaptığı ve
arıcıların %78.2’sinin yer ve konaklama sorunu olduğu saptanmıştır.
Yetiştiricilerin Bingöl arıcılık sektörünün gelişmesinin önündeki en büyük
etken olarak ilk 3 sırada %32.2 ile arıcıların yeterli bilgiye sahip olmaması,
%29.9 ile desteklemenin yetersiz olması ve %23 ile pazarlama sorununu
gördükleri belirlenmiştir. Mesleki deneyim süresi fazla, kovan sayısı az ve
gezgin arıcılık yapan işletmelerin bal verimlerinin daha yüksek olduğu tespit
edilmiştir.

Sonuç olarak, arı yetiştiriciliğinde eğitim
konusunun ciddi düzeyde ele alınarak yerel ve ulusal basında eğitimlerin
verilmesi, arıcılıkla ilgili girdi temini ve arı ürünlerinin pazarlanmasında
üretici örgütlerinin etkinleştirilmesi için çalışmaların yapılması gerektiği
saptanmıştır. Mesleki deneyimi fazla ve konaklama sorununu çözmeyi başaran
gezginci arıcılık yapan yetiştiricilere yönelik strateji ve politikaların
geliştirilmesi bölgede bal üretim ve verim miktarını önemli oranda arttıracağı
belirlenmiştir.
KARAÇALI (Paliurus spina-christi Mill.) BALININ KARAKTERİSTİK ÖZELLİKLERİ
Authors: Malkoç Meltem , Kara Yakup , Özkök Aslı , Ertürk Ömer , Kolaylı Sevgi
Published: May 2019

Yapılan bu çalışma ile
Türkiye'nin Marmara ve Trakya bölgelerinde üretilen karaçalı (Paliurus spina-christi Mill.) ballarının
karakteristik özellikleri ile biyolojik aktif değerleri aydınlatıldı. Toplanan 18
adet karaçalı balları, Marmara bölgesinin farklı bölgelerinden, Bursa, Edirne
ve Kırklareli'nin tecrübeli arıcılardan 2018 yılında bal hasat sezonunda ve
çevresindeki üreticilerden temin edildi. Balların melissopalinolojik
analizleri, fizikokimyasal parametre olarak, pH, nem, renk, iletkenlik
ve optik rotasyon değerleri, kimyasal parametre olarak, prolin, şeker
bileşenleri, toplam fenolik,  flavonoid,
tanen miktarları ve fenolik profil analizleri yapıldı. Biyolojik aktif özellik
olarak antioksidan aktivite ve antimikrobiyal aktivite kapasiteleri
araştırıldı. Çalışmanın sonuçlarına göre balların palonojik analizleri %65 ile
%95 arasında monofloral özelliğe sahip olduğu bulundu. Elde edilen değerler,
karaçalı balının monofloral çiçek balı niteliğinde ve yüksek antioksidan ve
antimikrobiyal özelliklere sahip kıymetli bir bal olduğunu göstermektedir.
TİCARİ PROPOLİS EKSTRAKTLARININ KALİTE PARAMETRELERİ AÇISINDAN KARŞILAŞTIRILMASI
Authors: Keskin Merve
Published: May 2019

Propolis
biyolojik aktif değeri yüksek doğal bir arı ürün olduğu için takviye edici gıda
olarak değişik formülasyon ve paketlerde tüketilmektedir. Propolisin içeriği
toplanma biçimi ve zamanı, arı ırkı ve toplandığı bölgenin florasına bağlı
olarak değişmektedir. Bu nedenle standardize ham propolis elde etmek mümkün
değildir fakat farklı çözücüler kullanılarak hazırlanan propolis
ekstraktlarının standardize edilmesi mümkündür. Yapılan bu çalışma da
Türkiye'nin değişik market ve aktarlarından toplanan ticari propolis
ekstraktlarının bazı kalite parametreleri karşılaştırıldı. 20 değişik propolis
ekstraktının briks, balsam, toplam fenolik madde miktarı (TFM), toplam
flavonoid madde miktarı (TFMM) ve kondense tanen madde (KTM) miktarları
ölçüldü. Çalışma sonucunda briks değerinin etanolik propolis ekstraktları için
25 ile 61 arasında, balsam değerlerinin %7.1 ile %95 arasında, TFM’ nin %1 ile
%95 arasında, TFMM’nin %0.1 ile %7.8 arasında ve KTM’ nin %0.04 ile %0.4
arasında değiştiği tespit edildi. Propolis özütlerinin hazırlanması,
tüketilmesi ve standardize edilmesinde bu parametrelerin önemli rol alabileceği
görülmektedir.
Évaluation anonyme et continue de la satisfaction des familles des patients hospitalisés en réanimation par l’outil Opinion Family
Authors: Allain M.-C. , Besson J.-M. , Blanchard P.-Y. , Roge L. , Flechel A. , Djibre M. , Fartoukh M. , Labbe V. ,   Groupe Mieux Vivre la Réanimation
Published: May 2019

En faisant partie intégrante du processus de soins, les familles des patients hospitalisés en réanimation sont exposées à des agressions à l’origine de troubles psychologiques. Ces situations de fragilité peuvent être, au moins en partie, prévenues par une prise en charge des familles de qualité. Au même titre que la démarche qualité implique l’évaluation de la satisfaction des patients, il paraît donc indispensable de recueillir celle des familles. L’outil OpinionFamily® (OF) a été conçu en partenariat avec une société experte afin de recueillir de façon anonyme, ergonomique, objective et continue la satisfaction des familles concernant leur perception de la qualité de leur prise en charge et de celle de leur proche sur une borne tactile sécurisée disposée dans la salle d’attente. L’analyse en temps réel des réponses permet l’évaluation des pratiques et la mise en place d’actions d’amélioration. Une étude de faisabilité au sein de la réanimation médicochirurgicale de l’hôpital Tenon de mars 2017 à août 2017 a permis le recueil de la satisfaction de 146 proches, essentiellement les référents des patients. L’identification et la disponibilité des soignants, le temps d’attente avant les visites, le confort de la salle d’attente ainsi que l’information relative à l’évolution de l’état de santé des patients demeurent les principaux items nécessitant la mise en oeuvre d’actions d’amélioration. L’implémentation systématique de l’outil OF dans les salles d’attente de réanimation offrirait aux soignants la possibilité de mieux connaître les besoins des familles en fonction de l’organisation mise en place, ainsi que d’évaluer régulièrement les améliorations effectuées.
ANALISIS AKUNTABILITAS PELAYANAN KANTOR LURAH BUKIT TIMAH KECAMATAN DUMAI SELATAN KOTA DUMAI DALAM PELAKSANAAN PELAYANAN ADMINISTRASI KEPENDUDUKAN
Authors: Erlianti Dila
Published: May 2019

Kelurahan as the lowest administrative government unit in the process of implementing services that come into direct contact with the community is very important in implementing service principles, both institutions that carry out services and target groups that receive administrative services in the kelurahan. The purpose of this study is to see transparency, accountability, conditional, participatory, equal rights, balance of rights and obligations and factors that influence population administration services. The research method used with a quantitative approach with a sample population with questionnaire techniques and interviews with data analysis using descriptive statistics and scale of data measurement using a rating scale. The results of the research show that the service is good enough and is influenced by participatory and equal rights in a service process as well as the factors that hinder the lack of transparency and accountability in the implementation of services.
UPAYA PEMBERIAN PELAYANAN PUBLIK DI UPT PUSKESMAS BALAI MAKAM KABUPATEN BENGKALIS
Authors: Afrizal Dedy , Effendi Nahar , Handayani Pertiwi
Published: May 2019

Public services provided by service providers must be synchronized with act no.25 of 2009 on public services in which there are stipulation of services, goods services, and administrative services for the society. The technical services unit (upt) of the puskesmas balai makam subdistrict of bathin solapan, bengkalis regency is a type of non-inpatient puskesmas under the supervision of the bengkalis district health service that provides services to the society, especially health services, however the facilities and infrastructure are not well implemented, payment system is not in accordance with the standard, and the problem of lack of availability of medicines for people who need health services. This study will elaborate the conduct of the services at how the implementation of services, supporting factors and inhibiting factors of health services. The result of the study will refer to the implementation of 5 indicators such as tangibles, reliability, responsiveness, assurance, emphaty are obtained a total score of 3,974 (88.31%) for the good category
Histiocitosis de células de Langerhans: El “camaleón” de la Dermatopediatría
Authors: Dossi-Cataldo María Teresa , Majluf Cáceres Paula , Gompertz Mattar Matías , González-Bombardiére Sergio
Published: May 2019

La Histiocitosis de Células de Langerhans (HCL) es una neoplasia mieloide de las células dendríticas Langerhans (CDL), caracterizada por acúmulos de células dendríticas mieloides CD207+. Corresponden a un espectro de enfermedades, desde sólo cutáneas a variantes multiorgánicas. El objetivo de este reporte es describir el caso clínico de un paciente pediátrico, enfatizando el algoritmo clínico. Paciente masculino de 1 año y 5 meses, con antecedente de otorrea persistente refractaria a tratamiento de un año de evolución. Consulta en policlínico de dermatología por “dermatitis severa” desde hace 1 año. Al examen físico se constatan lesiones tipo dermatitis seborreica generalizadas en tronco y cuero cabelludo,  intertrigo fisurado, pápulas eritemato-costrosas plantares con petequias y pus en conducto auditivo externo bilateral. Presenta Hemoglobina 9,5 mg/dl, Hematocrito: 31,9%, leucocitos: 12.400, linfocitos 33,3%, plaquetas: 920.000, VHS 27.  Subpoblaciones linfocitarias: CD3: 34,7%, C4: 22,7%, CD8: 9,7%, CD19:47,8%. HTLV negativo, VIH negativo. Acaro-test negativo. Dermatopatología: Infiltrado de células linfomonocíticas denso en dermis papilar con ensanchamiento de las mismas y gran epidermotropismo, con abundante citoplasma eosinófilo con núcleos arriñonados, CD1a y langerina positivo. Recomendamos elevar la sospecha diagnóstica ante un cuadro de dermatitis seborreica generalizada que esta fuera del rango etario característico y en casos  de dermatitis refractarias, donde a pesar de un adecuado tratamiento médico, el paciente persiste comprometido.
Variables clínicas, de laboratorio e histopatológicas en Síndrome de hipersensibilidad o erupción por drogas con eosinofilia y síntomas sistémicos (DRESS)
Authors: Ramírez-Cornejo Cristian , Downey-Saldivia Camila , Del Puerto-Troncoso Constanza , Del Barrio- Diaz Pablo , Vera-Kellet Cristian , Andino-Navarrete Romina
Published: May 2019

Introducción: La reacción a drogas con eosinofilia y síntomas sistémicos (DRESS) es una enfermedad poco frecuente que puede ser letal. Objetivo: Describir los hallazgos clínicos, de laboratorio e histopatológicosen pacientes con DRESS. Metodología: Estudioretrospectivo de fichas clínicas de pacientes conDRESS entre los años 2007 y 2017 con scoreregiSCAR mayor o igual a caso probable. Resultados: Se estudiaron 24 pacientes: 14 fueron mujeres (58,3%), la edad promedio fue 45,04 años DS 17,2(16-78). Los medicamentos frecuentemente implicados fueron Lamotrigina (33,3%) y Carbamazepina (20,8%).La latencia fue de 28 días DS 17,7 (10-90). La clínica más frecuente fue prurito 87,5%, fiebre 75%, edema facial 62,5% y adenopatías 45,8%. En laboratorio lo más alterado fueron pruebas hepáticas (70,8%) yeosinofilia (45,8%). 11 pacientes (45,8%) presentaroneosinófilos en la histopatología y 21 pacientes (87,5%)fueron tratados con corticoides. La mortalidad fue de11,1% (2 pacientes) por causas distintas a DRESS.Discusión: DRESS es una reacción adversa a medicamentos severa con hallazgos clínicos y de laboratorio muy variados y evolutivos, requiriendo su conocimiento para no retrasar su diagnóstico ytratamiento.
ВЛИЯНИЕ ЗАЩИТЫ ПРЕЗЕНТАЦИИ КАК ИНСТРУМЕНТА СУММАТИВНОГО ОЦЕНИВАНИЯ НА ПРОЯВЛЕНИЕ ПРОФЕССИОНАЛЬНОЙ ИДЕНТИЧНОСТИ УЧИТЕЛЕЙ
Authors: КОЛЕСОВА ЛЮДМИЛА ГЕННАДЬЕВНА
Published: May 2019

В данной статье рассматриваются особенности защиты пре-зентации как инструмента суммативного оценивания по итогам обучения на курсах повышения квалификации учителей. Отмечается, что наличие вербального плана (доклада) в презентации позволяет проявиться такому спонтанному социально - психологическому качеству личности как профессиональная идентичность, которое является мотивационной основой принятия перемен. Посредством изучения содержания докладов по презентациям (видеозапись), в которых учителя рассказывают об овладении умением составлять краткосрочный план урока (новый аспект профессиограммы), фиксируются проявления уровней про-фессиональной идентичности. Полученные результаты проанализированы. Выделены факторы, оказывающие влияние на уровень развития профессиональной идентичности. Сделаны обоснованные выводы. Статья представляет интерес для руководителей методических служб школ и центров обучения учителей.
КАК РАЗРАБОТАТЬ ИНСТРУМЕНТЫ ДЛЯ ОЦЕНИВАНИЯ ПЕДАГОГИЧЕСКОЙ ПРАКТИКИ
Authors: КОЛЕСОВА ЛЮДМИЛА ГЕННАДЬЕВНА
Published: May 2019

В статье раскрывается актуальность использования экспертами по оцениванию инструментов в процессе наблюдения практики преподавания тренеров курсов повышения квалификации учителей и руководителей общеобразовательных организаций Республики Казахстан. В соответствии с целями проведения наблюдения, инструменты условно подразделены на две группы: инструменты для сбора информации о практике преподавания и инструменты для рефлексии и последующего фокусного развития профессиональных навыков. Приведены образцы разработанных инструментов, раскрыт алгоритм их применения, названы ограничения в использовании, выявленные в ходе апробации. Автор даёт теоретическое обоснование эффективности использования приведённых инструментов для поддержки развития и саморазвития практики педагогов.
APOE Effect on Amyloid-β PET Spatial Distribution, Deposition Rate, and Cut-Points
Authors: Toledo Jon B. , Habes Mohamad , Sotiras Aristeidis , Bjerke Maria , Fan Yong , Weiner Michael W. , Shaw Leslie M. , Davatzikos Christos , Trojanowski John Q. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: May 2019

There are conflicting results regarding how APOE genotype, the strongest genetic risk factor for Alzheimer’s disease (AD), influences spatial and longitudinal amyloid-β (Aβ) deposition and its impact on the selection of biomarker cut-points. In our study, we sought to determine the impact of APOE genotype on cross-sectional and longitudinal florbetapir positron emission tomography (PET) amyloid measures and its impact in classification of patients and interpretation of clinical cohort results. We included 1,019 and 1,072 Alzheimer’s Disease Neuroimaging Initiative participants with cerebrospinal fluid Aβ1 - 42 and florbetapir PET values, respectively. 623 of these subjects had a second florbetapir PET scans two years after the baseline visit. We evaluated the effect of APOE genotype on Aβ distribution pattern, pathological biomarker cut-points, cross-sectional clinical associations with Aβ load, and longitudinal Aβ deposition rate measured using florbetapir PET scans. 1) APOE ɛ4 genotype influences brain amyloid deposition pattern; 2) APOE ɛ4 genotype does not modify Aβ biomarker cut-points estimated using unsupervised mixture modeling methods if white matter and brainstem references are used (but not when cerebellum is used as a reference); 3) findings of large differences in Aβ biomarker value differences based on APOE genotype are due to increased probability of having AD neuropathology and are most significant in mild cognitive impairment subjects; and 4) APOE genotype and age (but not gender) were associated with increased Aβ deposition rate. APOE ɛ4 carrier status affects rate and location of brain Aβ deposition but does not affect choice of biomarker cut-points if adequate references are selected for florbetapir PET processing.
Neuropsychiatric Symptoms and Risk of Progression to Alzheimer’s Disease Among Mild Cognitive Impairment Subjects
Authors: Dietlin Simon , Soto Maria , Kiyasova Vera , Pueyo Maria , de Mauleon Adelaïde , Delrieu Julien , Ousset Pierre Jean , Vellas Bruno
Published: May 2019

Background:

Neuropsychiatric symptoms (NPS) are prevalent in mild cognitive impairment (MCI), but we do not know much about their role in progression to dementia.

Objective:

To investigate NPS and the risk of progression to probable Alzheimer’s disease dementia (AD) among subjects with MCI.

Methods:

96 MCI participants were followed for 4 years. Progression to probable AD was defined by the change of CDR total score from 0.5 to ≥1, reviewed by an expert consensus panel. NPS were determined using the Neuropsychiatric Inventory (NPI) 12-items. This study analyzed prognostic value of each NPI item and 5 sub-syndromes of NPS (apathy, psychosis, affective, hyperactivity, and vegetative) for prediction of progression to probable AD. A Cox proportional hazard model was used; hazard ratios (HRs) and 95% confidence intervals (CIs) were estimated with time dependent variable to compare the incidence of progression considering presence/absence of any NPS or sub-syndromes throughout the study.

Results:

The presence of symptoms “agitation/aggression”, “delusions”, and “aberrant motor behavior” significantly increased the risk of probable AD (HR = 3.9; 95% CI = 1.9–8.2; HR = 13.9; 95% CI = 4.1–48.9; HR = 4.3; 95% CI = 1.7–10.3, respectively). The presence of sub-syndromes “psychosis” and “hyperactivity” were also predictors of progression (HR = 14.0; 95% CI = 4.4–44.5; HR = 2.0; 95% CI = 1.1–3.7, respectively). These results did not change after adjusting by potential confounders.

Conclusion:

Presence of delusions, agitation/aggression, and aberrant motor behavior is predictor of progression to probable AD.
Quantum chemical and molecular docking studies on two potential hepatitis C virus inhibitors
Authors: Tiwari Gargi , Srivastava Ambrish Kumar , Kumar Ratnesh , Kumar Abhishek
Published: May 2019

Hepatitis C virus (HCV) is responsible for various clinical conditions ranging from acute viral hepatitis to chronic liver disease and cirrhosis, causing liver cancer. The inhibition of HCV NS5B polymerase is a major step towards design of anti-HCV drugs. This study is devoted to two potential inhibitors of NS5B polymerase using quantum chemical and molecular docking methods. The structures of these molecules have been optimized using density functional theory at B3LYP/6–311++G (d,p) level. The vibrational spectral analyses of these two molecules have been performed in detail. The calculated vibrational spectral studies of both the title compounds are in good agreement with previous result. The frontier orbital surfaces and molecular electrostatic potential surfaces have been analyzed. The energy gap between HOMO and LUMO suggest that the compd2 is more reactive than compd1. The molecular electrostatic potential plots suggest the suitable nucleophilic and electrophilic sites in title compounds. Various electronic and thermodynamic parameters of both molecules have been calculated and compared. Finally, the inhibition activity of these compounds with the help of molecular docking studies, against NS5B polymerase enzyme has been explored. The result of docking studies suggests that these compounds are emerging as an effective potent inhibitor of HCV NS5B polymerase and can be useful in the design of novel anti-HCV drugs.
New water-soluble cationic indium (III) phthalocyanine bearing thioquinoline moiety; Synthesis, photophysical and photochemical studies with high singlet oxygen yield
Authors: Kutlu Öznur Dülger , Avcil Dilan , Erdoğmuş Ali
Published: May 2019

The synthesis and characterization of (4) - tetra[2-thioquinoline]phthalocyaninato indium (III) (2) and quaternized (4)- tetra[2-thioquinoline]phthalocyaninato indium (III) (3), are described. Photochemical and photophysical properties of 2 and 3 in DMSO; and of 3 in water are also presented. A comparison between the photophysical and photochemical parameters of 2 and 3 showed that 2 is a better photosensitizer than 3. The quantum yield values of fluorescence ( ΦF), and singlet oxygen formation ( Φ Δ) for 2 are 0.012 and 0.74, respectively. These values are higher than those for 3, which exhibited the values 0.006 and 0.66, respectively. The values for 3 in aqueous solution are 0.002 and 0.17 (0.42 plus Triton X-100) respectively due to aggregation behavior in the solution, and these values suggest that indium phthalocyanine 2 and its water-soluble derivative 3 can find use as photosensitizer in the photodynamic therapy (PDT) of cancer.
RETRACTED: Synthesis, anti-gastric cancer activity and docking studies of naphthol derivatives
Authors: Shao Hua , Kong Cui , Yang Qi-Hua , Tai Qing-Pin
Published: May 2019

This article has been retracted, and the online PDF has been watermarked “RETRACTION”. The retraction notice is available at http://doi.org/10.3233/MGC-220954 .
Evaluasi Penerapan Program Penghematan Air Bersih di Gedung Perkantoran (Studi Kasus Penghematan Air Bersih di Gedung Perkantoran PT TEPI)
Authors: Kartika Siska Ayu
Published: May 2019

Kebutuhan dan pemakaian air bersih terus meningkat setiap tahunnya, seiring dengan pertumbuhan penduduk, jumlah industri dan gedung-gedung perkantoran. PT TEPI sebagai salah satu perusahaan di Balikpapan, berpacu untuk turut serta melakukan upaya penghematan air demi masa depan yang lebih baik, sejalan dengan penerapan Sistem Manajemen Lingkungan ISO 14001 diperusahaan tersebut. Tujuan dari penulisan paper ini adalah untuk melakukan identifikasi upaya-upaya dalam melaksanakan kegiatan penghematan air di gedung perkantoran dan mengevaluasi penerapan program penghematan penggunaan air bersih yang telah dilakukan. Metodologi penelitian ini dilakukan dengan mengumpulkan data sekunder, melakukan survei dan obervasi lapangan, mengevaluasi penggunaan air bersih dengan menghitung berapa penghematan yang dapat dilakukan sebelum dan sesudah dilakukan beberapa perbaikan. Program penghematan air yang telah dilakukan diantaranya adalah komitmen dari manajemen puncak untuk mendukung secara penuh pada gerakan penghematan air, pembentukan tim komite hemat energi dan air, melakukan sosialisasi peningkatan kesadaran karyawan, deteksi kebocoran air, memperbaiki kran bocor dan meter air yang rusak, mengganti kran manual menjadi kran autostop, pemakaian dual flush toilet, dan sprinkler untuk menyiram tanaman. Melalui gerakan ini, PT TEPI telah melakukan penurunan pemakaian air sebesar 34,18% terhitung mulai dari tahun 2009- 2017, dan rata-rata pemakaian air perkapita adalah sebesar 312,44 L/orang/hari.
On a segmentation of Coopextra customers in Thu Duc district
Authors: Hong Dien Le , Phuc Son Nguyen , Hoang Uyen Pham , Van Hinh Le
Published: May 2019

Customer segmentation is the process of grouping customers based on similar characteristics such as behavior, shopping habits…so that businesses can do marketing to each customer group effectively and appropriately. Customer segmentation helps businesses determine different strategies and different marketing approaches to different groups. Customer segmentation helps marketers better understand customers as well as provide goals, strategies and marketing methods for different target groups. This paper aims to examine the customer segmentation using clustering method in statistics and unsupervised machine learning. The algorithms used are K-means and Elbow which are famous algorithms that have been successfully applied in many areas such as marketing, biology, library, insurance, finance... The purpose of clustering is to find meaningful market segments. However, the adoption and adjustment of parameters in the algorithms so as to find significant customer segmentations remain a challenge at present. In this paper, we used data of customers of Thu Duc CoopExtra and found significant customer segmentations which can be useful for more effective marketing and customer care by the supermarket.
Conditions for the development of Vietnamese business and entrepreneurship in Poland
Authors: Hoang Tien Nguyen
Published: May 2019

This paper outlines the history of the development of Vietnamese business and Vietnamese businessmen and entrepreneurs community in Poland. This special period of history of development was to be divided into two main phases. In addition, this article has analyzed the factors affecting international entrepreneurship spirit and international entrepreneurship capacity of this Vietnamese business community here in Poland. These factors are well identified in the overview part of international startups and international entrepreneurship study. The study showed that these factors include: foreign market appeal, government policies, compatibility of business practices, and adaptability to foreign markets. In the research part of this article, these factors were taken to be reanalyzed for the Vietnamese business community in Poland and showed why Vietnamese people choose Poland to be a good place for family settlement and for doing long-term business. Moreover, the success factors and success barriers behind their business development compared to the community of Chinese businessmen and entrepreneurs who came to Poland just only several years later have also been clearly identified. The research results show that, to strengthen the position and to raise the business awareness of Vietnamese business community in Poland, to strengthen it into a more developed and unified community for the purpose of future sustainable development, Vietnamese embassy in Poland with all of its networks of partnership, Vietnam's foreign trade promotion and trade representative agencies, and the diverse Vietnamese associations in Poland, both for profit and non-profit, need to play an interactive role to support Vietnamese businessmen and entrepreneurs to understand indigenous business practices, to overcome language and culture barriers in a bid to better integrate with the Polish business and social environment.
METRONIDAZOLE (1%) AND CHLORHEXIDINE (0.25%) GEL AS AN ADJUNCT TO SCALING AND ROOT PLANING IN THE TREATMENT OF MODERATE TO SEVERE CHRONIC PERIODONTITIS—A CLINICAL STUDY.
Authors: Hussain Dr Huda , Jan Prof.(Dr.) Suhail Majid , Behal Dr. Roobal
Published: May 2019

Metronidazole and Chlorhexidine are commonly employed antimicrobial agents in the antinfective stage of periodontal therapy, used with the aim to achieve complete eradication of the pathogenic flora from the subgingival niches, in conjunction with professional debridement. This study was aimed to determine the adjunctive effect of a novel combination of metronidazole (1%) and chlorhexidine (0.25%) in a gel form for management of moderate to severe chronic periodontitis. Twenty subjects were included for a split mouth prospective study. Gingival index, Plaque Index, Bleeding scores and Probing depth were noted at baseline, 2 weeks and 1 month after scaling and root planing with or without an additional subgingival delivery of the antimicrobial gel. An improvement of periodontal health was seen after therapy, and the difference between the test and control sites was significant for sites with an initial probing depth of 6-8mm. However, for deeper pockets (>8mm) the difference was statistically non-significant. The reduction in bleeding score was sustained at the test sites throughout the study period. It was concluded that the adjunctive use of metronidazole (1%) and chlorhexidine (0.25%) gel could provide clinical benefit for the management of deep pockets uptil 8mm of initial probing depth.
CHANGE MANAGEMENT OF BANKING SYSTEM AT NATIONAL LEVEL BY RASTIN BANKING
Authors: Bidabad Bijan
Published: May 2019

The purpose of this study is to change huge structures such as the banking sector of a country needs special innovative methods. This paper shows how we can manage change in a banking sector of a country. Grafting novel efficient processes, and pruning old inefficient ones, and harmonising the organization with new processes and empowering the staff through apprenticeship and knowledge management can put forward the change management. The proposed method of “Prune and Graft of Process” similar to grafting a shoot or bud of a sweet-fruited tree to a bitter-fruited base tree is significant in change management. Accordingly, new processes should be grafted to the system, and all processes that are theoretically or practically against the goals of the organisation should be pruned. New processes and innovations could automatically change the bank performance. Apprenticeship and knowledge management are highly effective in all stages of forming and implementing the change. This plan was formed and tested in Bank Melli Iran in order to propose a model for other banks as well. In a view to explain the applied method of change management in the banking system, we study the steps that Rastin Banking was formed in Bank Melli Iran as a sample. Efficient changes and reforms of large organizations can prevent the society from enormous hurts.
Терористичні загрози закордонним дипломатичним установам України
Authors: Balitskyj V. V.
Published: May 2019

Стаття присвячена розгляду проблем забезпечення безпеки закордонних дипломатичних установ (ЗДУ) України в умовах виникнення терористичних загроз у країні акредитації. Зокрема, автором проаналізовані вирішення завдань забезпечення безпеки ЗДУ під час терористичних акцій в їх оточенні, при блокуванні представництв терористами та захопленні приміщень установ і їх співробітників як заручників.

Метою статті став пошук ефективних шляхів забезпечення безпеки закордонних дипломатичних установ України та їх персоналу під час терористичних акцій в країнах акредитації.

Наукова новизна статті полягає у дослідженні можливостей розробки сучасної системи організації в ЗДУ, адекватної протидії наявним викликам і загрозам терористичного характеру, а також відповідної актуалізації відповідних правових норм та інструкцій. У статті відпрацьовані конкретні рекомендації щодо дій в екстремальних ситуаціях під час терористичних акцій в оточенні ЗДУ, зокрема, при блокуванні представництв терористами чи захопленні їх приміщень злочинцями, а також утримуванні дипломатичних співробітників як заручників.

Висновки. Негативні тенденції сучасного світового розвитку такі як: прояви міжнародного тероризму, організованої злочинності, контрабанда наркотиків і зброї, нелегальна міграція і торгівля людьми; зростання екологічних і природних катастроф, загроз епідемій та пандемії; збереження ескалації заморожених конфліктів і поява нових джерел напруженості, виникнення кризових ситуацій, зокрема, активізація щодо України внаслідок подій на сході терористичної та розвідувально-підривної діяльності спецслужб РФ, покладають на СЗР України та інші спеціальні державні органи завдання належним чином забезпечувати національну безпеку держави, її закордонних дипломатичних установ, їх співробітників і членів сімей, а також відряджених за кордон українських громадян, обізнаних з відомостями, що становлять державну таємницю. Напрацьована світова практика та удосконалення нормативного регулювання у сфері зазначених питань сприятимуть вирішенню завдань забезпечення безпеки ЗДУ під час терористичних акцій в їх оточенні, при блокуванні представництв терористами та захопленні приміщень установ і їх співробітників як заручників.
Parametric Optimization and Experimental Validation for Nonlinear Characteristics of Passenger Car Suspension System
Authors: Mohd Avesh , Srivastava Rajeev
Published: May 2019

The study deals with the design of the automotive suspension system to better dynamic characteristics in an uncertain operating atmosphere. Vehicle design parameters are to be optimized to achieve better passengers comfort, vehicle body stability, and road holding as the measure of suspension system performance improvement. The design of experiments gives the optimum parametric combination in the domain on the basis of vertical body acceleration data obtained by simulation of a 2-DOF nonlinear quarter car model. Moreover, the nonlinear hysteric behavior foremost design parameters have been characterized through the theoretical and experimental analysis in order to validate the design and to check the analogical viability of the derived model. Finally, the proposed methodology ascertains the optimum design of the suspension system in the time and cost-effective manner. The developed passive design of car suspension system exhibits excellent vibrational characteristics and convinces the acceptable range of vehicle vibration as suggested by ISO-2631-1997.
Preliminary parameter characterization for numerical optimization of ducted propellers
Authors: Remaud Margot , Guilcher Pierre-Michel , Laurens Jean-Marc
Published: May 2019

In this paper, a preliminary parameter characterization for the numerical optimization of ducted propellers was performed. The ENSTA Bretagne in-house solver used is based on the potential flow theory. Although the potential flow solver is able to solve unsteady problems, in this preliminary study, only steady state flow problems are considered. Different parameters are analyzed, such as the gap between the propeller tip and the inner duct surface, as well as the propeller location in the duct tube. The analyses are carried out on a standard advance coefficient range. A quick study shows that a neutral NACA profile for the duct section can provide higher performance predictions than the classical accelerating Kort nozzle 19A. The parameter study shows that the best axial position for the rotor is not necessarily near the duct entrance and, more importantly, that a thinner duct profile can give better hydrodynamic performance.
The influence of omega-3 polynenasic fatty acids on the pathogenetic lines of arterial hypertension in the person with abdominal obesity
Authors: Vlasyk L.І. , Taschuk V.K. , Khrebtii H.I.
Published: May 2019

Hypertriglyceridemia is a characteristic feature of dyslipidemia in hypertension in patients with concomitant abdominal obesity. These individuals constitute an increased risk of cardiovascular complications, so optimizing their treatment is extremely important medical problem. The aim is to study the dynamics of the major lipid spectrum of the blood vessels and endothelial function as a marker of atherosclerosis, when you connect to the drug ω-3 polyunsaturated fatty acids to the standard combination of antihypertensive and lipid-lowering therapy in patients with hypertension and abdominal obesity. The analysis of the dynamics of lipidohramy and vascular endothelial function in patients with essential hypertension and abdominal obesity during the 6-month standard (basic) antihypertensive (lisinopril, amlodipine) and lipid-lowering therapy (atorvastatin) (group I) and accession thereto ω-3 polyunsaturated fatty acids (group II). When analyzing the results of 6 months of treatment in the studied patient groups in triglycerides reduction was significantly more pronounced when using combination antihypertensive and lipid-lowering therapy (-40,9+3,1% in group II and -22,7+2,3% in group I, p<0,001). Also in group II was marked significantly greater increase in HDL cholesterol (38,6+2,5% in group II and 28,7+2,6% in group I, p<0,05) and improved endothelium vasodilation (9,86+0,28% in group II and 6,8+0,23%, p<0,01). Thus, in patients with hypertension and concomitant abdominal obesity observed significant dyslipidemia, a characteristic feature of which is hypertriglyceridemia. Joining the standard antihypertensive and lipid-lowering therapy ω-3 polyunsaturated fatty acids contributes significantly more effective normalization of triglycerides. For persons with hypertension and concomitant abdominal obesity is characterized by endothelial dysfunction and significant additional purpose to standard therapy ω-3 polyunsaturated fatty acids leads to a significant improvement.

Key Words: arterial hypertension, obesity, dyslipidemia, endothelial function, free-3 polyunsaturated fatty acids.