bluuebunny/crossref_metadata_2025 huggingface dataset:
Importance de la pluviométrie dans la transmission potentielle des pathologies virales et parasitaires par les moustiques à Bamako (Mali)
Authors: KONE Massiriba , YARO Alpha Seydou , COULIBALY Boubacar , SAWADOGO Karim , DIWARA Mamadou Oumar , SODIO Bernard , DOUMMA Ali
Published: October 2024

Les moustiques sont les vecteurs de nombreuses maladies. Ils constituent une menace sans cesse croissante pour la santé. La présente étude s’est déroulée dans les six (6) communes de Bamako, au cours des années 2021 et 2022, pour les mois de juillet à décembre. Il s’est agi de déterminer l’impact de la pluviométrie sur le risque des maladies liées aux moustiques Trois quartiers ont été aléatoirement choisis dans chaque commune puis trente concessions par quartier. Ainsi, 540 chambres ont été prospectées par pulvérisation intra domiciliaire au pyrèthre ou « spray-catch ». Tous les moustiques morts ou moribonds tombés ont été collectés, identifiés et conservés à l’éthanol 90° dans des tubes au laboratoire. L’étude a permis la capture de 26090 moustiques en 2021dont 94,24% de Culex ; 5,17% d’Anopheles et 0,59% d’Aedes. En 2022, 16897 moustiques ont été capturés dont 93,41% de Culex ; 4,94% d’Anopheles et 1,65% d’Aedes. Des corrélations positives et hautement significatives ont été observées entre la densité de moustiques et la pluviométrie. Mots-clés : zone urbaine, Culicidae, paramètres climatologiques, Bamako
Medicalización de la vida cotidiana y crítica social en la literatura barroca: el nacimiento de don Gregorio Guadaña
Authors: Francés Hidalgo Beatriz
Published: October 2024

La edad Moderna es a menudo conocida como un período de grandes cambios en ciencia y tecnología con sus consiguientes repercusiones en la vida laboral, militar y filosófica de Occidente. La ciencia de la medicina no iba a ser menos, con grandes cambios tanto en su práctica como en su percepción por parte de la sociedad y su repercusión social. Surgió así el fenómeno conocido como medicalización, por el cual la medicina y sus principios se infiltraron en la vida cotidiana de la población general de la época. Este trabajo examina un fragmento de la novela "Vida de Don Gregorio Guadaña", escrita por Antonio Enríquez Gómez en 1644 durante su exilio en Francia. El análisis del fragmento revela la sátira aguda del autor hacia la medicalización de la vida cotidiana y la corrupción en la práctica médica. La narración, llevada al extremo de lo absurdo, la realiza el propio feto antes de nacer, ofreciendo una visión acerca del propio parto y los diferentes roles que se desenvuelven en el mismo.
Kadınların Beden Algısı ve Vücut İmajının Yemek Seçimine Etkisi
Authors: Koç Fatma , Öztürk Gülsevdi
Published: October 2024

Bu araştırma, katılımcıların yaş, meslek, eğitim düzeyi ve vücut tipine göre kadınların yemek seçimi, beden algısı ve vücut imajındaki farklılıkları incelemektedir. Katılımcıların çoğunluğu 30-35 yaş aralığında, lisans mezunu olduğu bulunmuştur. Katılımcıların çoğunluğu günde 2 öğün yemek yemekte ve en çok tüketilen yiyecek türleri sebzeler, etler, hamur işleri ve salatalardır. Araştırma, kadınların beden algısı ve yemek seçimi arasında belirli ilişkileri ortaya koymaktadır. Katılımcıların çoğunluğu, kilo hassasiyetinin yemek seçimlerini etkilediğini ve vücut şekillerini beğenmedikleri durumlarda beslenme alışkanlıklarını değiştirdiklerini belirtmektedir. Dış görünüş ve çevresel etmenlerin, özellikle medya ve sosyal çevre baskısının, yemek seçimlerini etkilediği gözlemlenmiştir. Yaş, eğitim düzeyi ve vücut tipi gibi faktörlere göre yapılan analizler, bu değişkenlerin kadınların yemek seçimi, beden algısı ve vücut imajı üzerindeki etkileri arasında istatistiksel olarak anlamlı farklılıklar olmadığını göstermiştir. Ancak, eğitim düzeyinin yemek seçimi üzerinde etkili olduğu belirlenmiştir. Araştırma, kadınların yaş, meslek, eğitim düzeyi ve vücut tipine bağlı olarak farklı beslenme alışkanlıkları ve beden algıları sergilediğini ortaya koymaktadır. Araştırma, kadınların vücut şekli ve kiloları ile ilgili algılarının, beslenme alışkanlıkları üzerinde belirleyici bir rol oynadığını vurgulamaktadır.
Genç Futbolcuların, Aerobik ve Anaerobik Kapasiteleri Futbola Özgü Teknik Becerilerini Nasıl Etkiler?
Authors: Köse Oğuzhan , Ceylan Ramazan
Published: October 2024

Bu araştırmanın amacı genç futbolcuların aerobik ve anaerobik kapasiteleri ve futbola özgü teknik becerilerinin incelenmesidir. Bu araştırmada nicel araştırma yöntemlerinden tarama modeli kullanıldı. Araştırmanın örneklem grubu Bayburt Özel İdare Spor Kulübü U-19 kategorisinde futbol oynayan 38 futbolcudan oluşturuldu. Futbolculardan antropometrik ölçümler (boy, kilo), anaerobik testler (dikey sıçrama testi, esneklik testi, illinois çeviklik testi, bacak kuvvet testi, yıldız denge testi), aerobik test (cooper testi) ve Mor-christian genel futbol yetenek testi (top sürme, şut ve pas isabeti) ölçümleri alındı. Araştırma sonucunda elde edilen ölçüm sonuçları SPSS 22 paket programına aktarılarak öncelikle normallik testi uygulandı. Yapılan ölçümlerde elde edilen verilerin ortalama ve standart sapma değerleri hesaplandı. Elde edilen sonuçlara göre veri dağılımının çarpıklık ve basıklık değerleri, Tabachnick ve Fidell (2013)’in bir verinin normal dağılıp dağılmadığının göstergesi olarak bildirdiği -1,5 ile + 1,5 arasında olduğu görüldü ve verilerin normal dağılım gösterdiği anlaşıldı. Normal dağılım gösteren bu veri setlerinin analizlerinde parametrik testlerden One Away Anova (Tek Yönlü Varyans Analizi) ve descriptives testleri yapıldı. Sporculara uygulanan testler sonucunda futbolcuların anaerobik testleri (çeviklik, esneklik, bacak kuvvet, dikey sıçrama ve yıldız denge) aerobik testi(dayanıklılık) futbola özgü becerilerin ve yeteneklerin (top sürme, şut ve pas isabeti) uygulanması üzerinde sırasıyla (p<,000-, p<,000-, p<,000) anlamlı farklılık olduğu bulgularına ulaşıldı. Çalışmanın sonucu olarak motor becerlerilerin (çeviklik, esneklik, kuvvet, dayanıklılık ve güç) futbola özgü teknik becerileri (top sürme, şut ve pas isabeti) olumlu yönde etkilediği düşünülmektedir.
Öğretmen Adaylarının Afetlere Yönelik Tutumlarının Sportif Aktivite ve Farklı Değişkenler Açısından İncelenmesi
Authors: Güneş Seyhun , Uçan İzzet
Published: October 2024

Öğretmen adaylarının afetlere yönelik tutumlarının; bilişsel, duyuşsal ve davranışsal boyutlarda sportif aktivite ve farklı değişkenler doğrultusundaki etkilerinin incelenmesi ve literatüre katkı sağlamaktır. Yöntem: Araştırmada, nicel araştırma yöntemlerinden ilişkisel tarama modeli kullanılmıştır. Çalışmada veri toplama aracı olarak 10 maddeden oluşan kişisel bilgi formu, 23 madde ve 3 alt boyuttan oluşan (bilişsel, duyuşsal, davranışsal) Afet tutum ölçeği kullanılmıştır. Bulgular: SPSS25 paket programı kullanılarak 550 öğretmen adayının katıldığı çalışmada, 401 kadın, 149 erkek katılımcı bulunmaktadır. Katılımcıların yaş ortalaması 23,46 ± 3,44 , 434'ü çekirdek aile yapısına, 116'sı geniş aile yapısına sahiptir. 100 katılımcı kırsal bölgelerde, 450 katılımcı ise kentsel bölgelerde yaşamaktadır. 235 katılımcı bir afetle karşılaşmışken, 57'si yakınlarını afette kaybetmiştir. 147 katılımcı afet eğitimi almışken, 403 katılımcı almamıştır. 321 katılımcı aktif olarak spor yapıyor, spor yapan katılımcıların haftalık aktivite sürelerinin ortalaması ise 6,04 ± 5,09'dır. Araştırmada cinsiyetler arası farklılıkta kadın katılımcıların istatistiksel olarak anlamlı farklılık gözlenirken, katılımcıların artan yaş düzeyleriyle afet tutum ölçeği alt boyutlarıyla negatif yönlü anlamlı ilişki olduğu saptanmıştır. Afet tutum ölçeği alt boyutları bilişsel ve davranışsal alt boyutlar afete maruz kalan, afette yakınını kaybeden, afet eğitimi alan ve sportif aktivitelere katılım gösteren bireyler lehine anlamlı farklılıklar içermektedir. Yanı sıra sportif aktivite süresinin davranışsal alt boyutuyla pozitif yönlü anlamlı ilişki olduğu görülmektedir. Sonuçlar: Öğretmen adaylarının afetlere yönelik tutumlarının bilişsel, duyuşsal ve davranışsal boyutta çeşitli değişken ve sportif aktivite üzerinde olumlu etkileri olmuştur. Bu tutum yalnızca öğretmen adaylarının değil, öğrencilerin ve toplumun genel hazır bulunuşluluğu açısından büyük bir öneme sahip olduğu düşünülmektedir.
Çocuklarda Ritim Eğitimi ve Önemi
Authors: Sepil Yasin , Nişli Yunus
Published: October 2024

Ritim eğitimi ve dans, çocukların fiziksel, duygusal, sosyal ve bilişsel gelişimlerini destekleyen önemli bir pedagojik araç olarak eğitim programlarında yer almaktadır. Ritim, çocukların motor becerilerini geliştirmelerine, vücut koordinasyonlarını artırmalarına ve hareketlerini daha bilinçli bir şekilde kontrol etmelerine yardımcı olur. Bu, spor aktiviteleri ve genel motor gelişimle doğrudan ilişkili olup, çocukların özgüven kazanmasını sağlar.
Dans, aynı zamanda çocukların duygusal ifadelerini dışa vurmalarına olanak tanıyan yaratıcı bir süreçtir. Dans yoluyla çocuklar, kendilerini daha iyi ifade etmeyi öğrenir ve grup içi etkileşimler aracılığıyla sosyal becerilerini geliştirirler. Özellikle iş birliği, empati ve takım çalışması gibi sosyal beceriler, dans etkinlikleri sırasında güçlenir.
Bilişsel olarak, ritim eğitimi ve dans çocukların dikkat ve odaklanma yeteneklerini geliştirir. Müziğe ve ritme uygun hareket ederken, çocuklar beyin-zihin bağlantılarını kuvvetlendirir, bu da dil gelişimi, matematiksel düşünme ve problem çözme gibi akademik becerilere katkıda bulunur.
Eğitim programlarında ritim ve dansın entegrasyonu, çocukların farklı öğrenme stillerine hitap eden bütünsel bir yaklaşım sunar. Bu etkinlikler, eğitimi daha eğlenceli ve interaktif hale getirerek öğrencilerin derse olan ilgilerini artırır ve aktif öğrenmeyi teşvik eder. Böylece ritim eğitimi ve dans, çocukların kişisel ve akademik başarılarına önemli bir katkı sağlar.
Wohn‐ und Gewerbebau Buggi 52
Authors: Duttlinger Herbert , Ganter Benedikt
Published: October 2024

Bei dem achtgeschossigen Holzbau „Buggi 52“ ist es den Architekten gelungen, auf knapp 900 m2 Grundfläche einen Supermarkt, und in den Holzgeschossen darüber (mit je 400 m2 Grundfläche) einen Kindergarten und 30 Wohnungen unterzubringen. Erd‐ und Untergeschoss des etwa 25 m hohen Neubaus in der Bugginger Straße 52 im Freiburger Stadtteil Weingarten wurden in Stahlbetonbauweise ausgeführt. Darauf setzen sieben weitere Geschosse in reiner Holzbauweise auf. Errichtet wurden sie – inklusive der Erschließung – innerhalb weniger Wochen, überwiegend als ressourceneffizienter Holzrahmenbau. Aufgrund der Gebäudehöhe und die daraus resultierende Einstufung in die Gebäudeklasse 5 (Sonderbau) hatte der Mehrgeschosser besondere Anforderungen an den Brand‐ und Schallschutz zu erfüllen. Dies schlug sich in vielen Konstruktionsdetails des Holztragwerks nieder, unter anderem auch in der Wahl der Holzrahmenbauweise für die Gebäudehülle und die Flurwände in Kombination mit Treppenhäusern und Aufzugschächten aus Brettsperrholz als Aussteifungselemente. Hinzu kommt der Einsatz von hoch belastbarem Buchen‐Furnierschichtholz, auch als BauBuche bekannt, für Schwelle und Rähm in den Holzrahmenbau‐Elementen sowie nicht glimmbare Dämmstoffe für die Holzfassade aus Weißtanne. Buggi 52 wurde in serieller Bauweise weitgehend vorgefertigt und aus regional verfügbaren Materialien erstellt. Damit ist es nicht nur ein KfW 55‐Gebäude, sondern wurde auch als erstes Bauvorhaben Deutschlands FSC‐zertifiziert. Projektentwicklung: sutter3 GmbH & Co. KG, Freiburg Generalunternehmen Holzbau: Holzbau Bruno Kaiser GmbH, Bernau im Schwarzwald Architektur: Weissenrieder Architekten BDA, Freiburg Tragwerksplanung: Die Holzbauingenieure, Titisee‐Neustadt, mit Albrecht und Schneider, Freiburg Auszeichnungen: Deutscher Holzbaupreis 2023, Holzbaupreis Baden‐Württemberg 2022, Freiburger Holzbaupreis 2022, Beispielhaftes Bauen 2022
Effect of Cold Exposure on the Biofoam Produced from Different Types of Oyster Mushroom
Authors: Tan Siu Siew , Majib Nur Mawaddah , Sam Sung Ting , Yaacob Noorulnajwa Diyana
Published: October 2024

Mycelium-based biofoam is a sustainable material derived from the growth of fungal mycelium on lignocellulosic agricultural waste substrate, as it has potential use in a variety of applications. The main objective of this research is to advance the sustainable alternatives for various application by investigating the mycelium growth of the biofoam produced from Pleurotus florida and Pleurotus sajor-caju on rice husk substrate, in improving the properties of the biofoam through innovative cold exposure. This study showed P. florida can produce mycelium biofoam at a faster rate, 7.022mm/day compared to P. sajor-caju 6.08mm/day). By cold exposure at 0°C and 10°C for 3 hours, every 2 days and 5 days, respectively until the mycelium are fully grown in the substrate, sample exposed to the latter condition for P. florida exhibits a faster growth rate at 7.3037 mm/day. However, cold exposure on biofoam produced from P sajor-caju had not improved the mycelium growth rate. Cold exposure samples at 0°C every 5 days and 10°C every 2 days have demonstrated capability in water (103.51%) and oil absorption (143.23%), proving their effectiveness in absorbing pollutants for the purpose of environmental remediation. The FTIR analysis confirmed the presence of hydrophilic and oleophilic characteristics in the biofoam, indicating its capability to absorb water and oil. By subjecting biofoam to cold exposure, its properties can be altered, broadening its potential applications.
Antioxidant And Xanthine Oxidase Inhibitory Activity of Sesbania grandiflora Extract
Authors: Gunny Ahmad Anas Nagoor , Azri Ahmad Iqrak , Che Mat Mohd Hishamuddin , Salim Syaheerah Syazana Syalabiah , M. Abdul Kader Mohamed Mydin
Published: October 2024

Xanthine oxidase is a crucial enzyme in the regulation of uric acid, with elevated levels leading to gout and hyperuricemia. To combat these conditions, a synergistic approach using antioxidants and xanthine oxidase inhibitors presents a promising treatment strategy. Given the side effects of synthetic inhibitors, this study explores the natural xanthine oxidase inhibitory and antioxidant properties of Sesbania grandiflora leaves extract. The analysis revealed a significant free radical inhibition rate of 61.59 ± 0.90% at a concentration of 100 µg/mL. The SC₅₀ value for the leaves extract was 16.59 ± 0.67 µg/mL, compared to 7.76 ± 0.23 µg/mL for gallic acid, a positive control. The leaves extract also demonstrated notable efficiency in inhibiting uric acid formation, with an IC₅₀ value of 0.36 ± 0.341 µg/mL, although this was higher than the 0.01 ± 0.005 µg/mL value for allopurinol. A strong correlation (r = 0.9958) was found between the antioxidant activity and xanthine oxidase inhibition of the extract, underscoring its effectiveness. This study is the first to report the combined effects of xanthine oxidase inhibition and antioxidant activity in Sesbania grandiflora, highlighting its potential as a natural treatment for gout and related diseases.
Effect of magnetic field on the structural, optical, and electrical properties of CdS nanoparticles in distilled water by using pulsed laser ablation
Authors: Yamamah K. Abdalaah  , Olfat A. Mahmood  , Suaad S. Shaker
Published: October 2024

In this study, we investigated the impact that the incorporation of a magnetic field has on the properties of cadmium sulfide CdS nanoparticles as well as the performance of an n-CdS/p-Si heterojunction photodetector that was developed by the use of the pulsed laser ablation in a liquid method. Nd:YAG laser pulses (1.064 μm, 550 mJ) were utilized to ablate cadmium sulfide CdS nanoparticles in water. The synthesized nanoparticles were shown to have a polycrystalline hexagonal structure, as evidenced by the findings of the X-ray diffraction experiment, the crystallite size for cadmium sulfide CdS decreased from 4.611 nm to 4.518 nm. The lattice constants of cadmium sulfide CdS nanostructures were determined to be a = 4.1302, c = 6.702, and c/a=1.622. The strain and dislocation density of cadmium sulfide CdS exhibited an increase. Images taken from a field emission scanning electron microscope demonstrated the formation of spherical nanoparticles on the surface. A magnetic field was applied, increasing the CdS film's crystallinity. As a consequence of this enhancement, the particle size of the CdS decreased from 25.18 nm to 12.17 nm. A comparison was made between this and the size of the crystallites that appeared when no magnetic field was present. The EDS spectrum of magnetically prepared cadmium sulfide CdS films indicates the presence of Cd and S, and the weight percentage ratios [Cd]/[S], increase from 3.72 to 3.80. The transmission electron microscopy (TEM) pictures of CdS samples that were generated using a magnetic field contained particles of small size with a mean of 10.10 nanometers. From the FT-IR spectra of cadmium sulfide CdS prepared using a magnetic field within 400–4000 cm−1, the peaks (bands) of cadmium sulfide CdS at 617 cm−1 represent the bending vibration of Cd-S.  As a result of the influence of a magnetic field, the optical energy gap of CdS nanoparticles increased from 2.30 eV to 2.72 eV, as indicated by the UV-Vis study. From PL emission spectra the values of the energy band gap of cadmium sulfide CdS increased from 2.45 eV at 505.7 to 2.47 eV when a magnetic field was applied. CdS NP films produced under the influence of a magnetic field were identified as having n-type characteristics by Hall effect assessments, Particle mobility was influenced by particle size. The effect of applying a magnetic field on the efficiency of the n-CdS/p-Si photodetector was investigated and analyzed. When a magnetic field was applied during ablation, the responsivity of n-CdS/p-Si heterojunction photodetectors increased from 0.498 A/W to 0.830 A/W at 510 nm. This was the result of the application of the magnetic field.
Hexagonal Enhanced Porous GaN with Delayed Integrated Pulse Electrochemical (iPEC) Etching
Authors: Nurul Syuhadah Mohd Razali  , Alhan Farhanah Abd Rahim  , Nur Sabrina Mohd Hassan  , Rosfariza Radzali  , Ainorkhilah Mahmood  , Syarifah Norfaezah Sabki  , Irni Hamiza Hamzah  , Mohaiyedin Idris  , Mohamed Fauzi Packeer Mohamed
Published: October 2024

This present study investigates the effect of time delay (Td) on the formation of porous GaN (P-GaN) using integrated pulse electrochemical (iPEC) etching. Porous GaN (P-GaN) was formed by etching an N-type GaN wafer with a 4% KOH electrolyte for 60 minutes under an ultraviolet (UV) lamp at a current density of 80 mA/cm2. A Td of 120 minutes was applied before electrochemically etching the P-GaN sample. The top view image of the field emission scanning electron microscopy (FESEM) revealed a significant difference when a Td was applied. A dense and uniform hexagonal P-GaN was obtained from the Td iPEC sample, while the non-Td sample exhibited a multi-layered hexagonal porous structure with unfinished pore-etched areas. Higher porosity and deeper pores were observed in the Td sample. Intense high-resolution X-ray diffraction (HR-XRD) peak intensity was observed in the Td iPEC sample with a lower full width half maximum (FWHM), indicating that the sample had better crystallinity. The Raman spectra of the sample anodized with a Td exhibited higher Raman peak intensity and a slight shift to a higher frequency concerning as-grown GaN, indicating better crystallinity and a tensile stress relaxation of 0.24 GPa. Post etching, a blue shift of the photoluminescence (PL) peak, from 364 nm (as-grown GaN) to 363 nm (P-GaN), was observed, and a small PL peak started to form around 385 nm compared to the as-grown GaN due to the relaxation of the tensile stress, which modified the bandgap. The PL peak intensity of the Td sample was higher than the non-Td sample, indicating that the porosity and uniformity allowed more light interaction with the material, resulting in more efficient photon absorption and emission. The results indicated that potentially efficient optoelectronics devices can be fabricated on a P-GaN using a combination of electroless and electrochemical etching of the GaN epitaxial layer.
2-Axis controlled spray pyrolysis deposition device for Dye-sensitized Solar Cell (DSSC)
Authors: Siti Nurhaziqah Abd Majid  , Muhammad Fikri Bakrin  , Mohd Khairul Ahmad  , Faridah Abu Bakar  , Nik Aziz Nik Ali  , Diani Galih  Saputri  , Noor Kamalia Abd Hamed  , Shazleen Ahmad Ramli  , Mohamad Hafiz Mamat  , Masaru Shimomura  , Suriani Abu Bakar  , Mohd Azwadi Omar  , Mohd Yazid Ahmad  , Jais Lias
Published: October 2024

Dye-sensitized solar cells (DSSCs) are a promising alternative to traditional silicon-based photovoltaic systems due to their efficient light-to-electricity conversion. A critical component of DSSCs is titanium dioxide (TiO2), responsible for converting light into electrical energy. Spray pyrolysis was one of the methods for fabricating TiO2 thin films. However, there are several drawbacks, such as challenges in particle size control, maintaining homogeneity of the thin film, and scalability issues during the deposition process. Modifications to the manufacturing process are necessary to achieve optimal performance in DSSCs, particularly with the thickness of the cell. This work focuses on the 2-axis spray pyrolysis process, a cost-effective way to create thin and thick films. In particular, it focuses on TiO2 thin films utilized as working electrodes in DSSC applications. The method was performed at different motor speeds, namely MS80, MS100, and MS120. The X-ray diffraction (XRD) spectrum showed that the dominance of the anatase phase appeared in an MS100. The UV-Vis results depict that the band gap value is 3.02 eV. The surface profiler analysis indicates that sample MS100 has an optimal thickness of 15.17 µm. The DSSC achieved 9.4% efficiency with sample MS100. This finding demonstrates that using 2-axis controlled spray pyrolysis deposition improves DSSC performance with an optimal motor speed.
Systemic Mastocytosis: Diagnosis and Management in 2024
Authors: Lee Stephanie
Published: October 2024

Mastocytosis is a group of clonal disorders characterized by an accumulation of neoplastic mast cells (MCs) in one or more organ systems. The clinical presentation of mastocytosis is heterogenous as are the clinical outcomes. For example, some variants are associated with near normal life expectancy, while others are amongst the most aggressive known malignancies. Mastocytosis can occur in both pediatric and adult populations and can be classified into three major groups: systemic mastocytosis (SM), cutaneous mastocytosis (CM), and localized mast cell sarcoma. This review will focus on SM in adults with the aim of providing a general overview of the (1) pathophysiology, (2) diagnostic approach, and (3) current treatment landscape in Canada.
Management of Chronic Myeloid Leukemia that is Intolerant or Resistant to Front-Line Treatment
Authors: Bilston Lisa , Jamani Kareem
Published: October 2024

With advances in treatment for chronic myeloid leukemia (CML), the natural history of chronic phase (CP) CML has changed, with most individuals expected to live a normal life expectancy. The goal of therapy for most is to achieve a long-term deep molecular response (DMR) with the potential for medication discontinuation and treatment-free remission (TFR).1 Currently, six oral therapies have been approved for CP-CML in Canada: (1) imatinib, a first-generation tyrosine kinase inhibitor (TKI); (2) dasatinib, (3) nilotinib, and (4) bosutinib, the second-generation TKIs (2G-TKIs); (5) ponantinib, a third-generation TKI; and (6) asciminib, specifically targeting the ABL Myristoyl pocket (STAMP) inhibitor. Classically, treatment for CP-CML has consisted of front-line imatinib and switching to a 2G-TKI upon treatment resistance or intolerance. Increasingly, patients are being prescribed an upfront 2G-TKI with the goal of achieving quicker and deeper molecular remissions and a TFR.2 Challenges arise in CML when treatment with either two TKIs (imatinib + 2G-TKI) or one 2G-TKI fails, given the lack of evidence to inform clinical decision-making at this juncture. This paper aims to define TKI failure and help guide the selection of second-line treatment after failure of front-line therapy.
An Evolving Paradigm in Borderline Resectable and Locally Advanced Pancreatic Cancer: Current Strategies and Opportunities for the Future
Authors: Zereshkian Arman , Tsang Erica S.
Published: October 2024

Pancreatic ductal adenocarcinoma (PDAC), a cancer of the gastrointestinal tract, has been increasing in incidence, with an estimated doubling worldwide over the past two decades. Despite increases in awareness and innovations in genomics and drug discovery, 5-year survival remains low, at only 10%. This is in part owing to the majority of patients being diagnosed at the advanced stage of the disease, in addition to chemotherapy recalcitrant disease.
Surgical resection is necessary for a potential cure, however, this is only possible for the 10% of patients who present with resectable disease and potentially for those with borderline resectable disease. Locally advanced pancreatic cancer accounts for approximately 30% of those with PDAC and most of those patients are often precluded from curative intent surgery due to major vascular invasion and local infiltration into peri-pancreatic soft tissue. In cases of locally advanced disease, induction chemotherapy is often used, identifying the subgroup of patients more suited for local treatments and those who may later develop metastases. The treatment regimens used for patients with locally advanced PDAC are often extrapolated from trials involving patients with metastatic disease. In some cases, responses to neoadjuvant therapy have allowed for surgical resection, albeit these aggressive resections were associated with significant morbidity.
There is growing interest in identifying the optimal neoadjuvant treatment for patients with borderline resectable pancreatic cancer (BRPC) and locally advanced PDAC (LAPC) in an effort to improve outcomes. Here we review therapeutic strategies for borderline resectable and locally advanced PDAC, with a focus on novel systemic therapy regimens, chemoradiation, and different radiation modalities.
Tortious Standard, Tortious Results: Improving the Approach Toward Contributory Conduct under Wisconsin's Crime Victim Compensation Statute
Authors: Mirus Emmerson A.
Published: October 2024

Each year in Wisconsin, thousands of victims of violent crime apply for state-sponsored compensation under the Crime Victim Compensation (“CVC”) statute, as they are constitutionally entitled to do. However, the CVC statute excludes from compensation any victim whose conduct “substantially contributed” to their injury or death. This standard replicates Wisconsin’s basic test for causation in negligence cases; a crime victim “substantially contributed” to their injury or death if their conduct was a substantial factor in causing it. As this Comment explains, the contributory conduct limitation’s causation analysis is incomplete. In negligence cases, Wisconsin courts look to several public policy factors to limit tortfeasors’ liability, even where their negligent conduct was a substantial factor in bringing about the plaintiffs’ injuries. The CVC statute’s “substantially contributed” standard involves no such public policy inquiry, which leaves the question of legal causation unanswered. Exacerbated by administrative rules that articulate a myriad of forms of contributory conduct for CVC adjudicators to scrutinize—including the victim’s consent, provocation, drug and alcohol consumption, recent criminal history, and incarceration status—the CVC statute’s contributory conduct limitation supplies punishingly broad grounds for dismissing meritorious CVC claims. This tortious standard wreaks torturous results—it fails vulnerable crime victims and the intent of the Wisconsin State Legislature. This Comment argues that the CVC statute’s “substantially contributed” standard must be changed and offers three improved alternatives. The first proposed approach increases the State’s burden of proof as to the contributory conduct limitation; it would oblige the State to prove that a victim substantially contributed to their injury or death beyond a reasonable doubt. The second proposed approach resembles Wisconsin’s contributory negligence statute. Denying a CVC claim under this approach would require a finding that the victim’s contributory conduct was a greater cause of their injury or death than the perpetrator’s criminal conduct. The third proposed approach adopts an adapted version of the first three public policy factors used to determine the scope of liability in negligence cases. This Comment ultimately advocates for the third, or “public policy factors,” approach. The “public policy factors” approach is optimal because it entails minimal procedural strain, is legally robust, and recaptures the legislative intent of the CVC statute. In essence, this Comment encourages an a pproach toward contributory conduct that increases victims’ access to the funds they need and deserve.
“Pra quê fazer teatro na escola?”: perspectivas do ensino de teatro na educação formal
Authors: Oliveira Júnior Jailton Ferreira de , Tavares Mauricio Antunes
Published: October 2024

O presente artigo busca compreender o desenvolvimento das práticas teatrais nas escolas de ensino básico regular, por meio de um levantamento das principais produções acadêmicas brasileiras em nível de mestrado e doutorado. Utilizando a Biblioteca Digital de Teses e Dissertações (BDTD) como principal fonte de dados, a pesquisa abrangeu produções de 2018 a 2023, utilizando o descritor "Ensino de Teatro para Adolescentes". Foram encontrados 63 trabalhos, dos quais 33 atenderam ao critério de incluir o teatro como processo de desenvolvimento artístico e pedagógico com adolescentes. Focando na prática artístico-pedagógica do teatro no ambiente escolar, a análise delimitou-se aos trabalhos desenvolvidos no contexto da educação formal, resultando em 13 produções relevantes. Este levantamento oferece uma visão abrangente das abordagens e práticas teatrais nas escolas, destacando seu potencial estético e pedagógico no desenvolvimento de adolescentes.
O espaço expositivo como laboratório de conhecimento em arte fundamentado na Abordagem Triangular
Authors: Reis Thais Rosa dos , Rueda Laura Marcela Ribero , Sant'Anna Denise Blanco
Published: October 2024

As contribuições da sistematização da Abordagem Triangular para o ensino da Arte no Brasil resultaram da eclosão dos discursos pós-modernos do final do século XX e das correntes de pensamento do ensino da arte, influenciando a estruturação dos três eixos que a fundamentam, a contextualização, o fazer e a leitura de imagem. Considerando a Abordagem Triangular proposta por Ana Mae Barbosa, a presente pesquisa tem como objetivo discutir a sua aplicação enquanto estratégia de mediação artística, cultural e social, compreendendo o espaço expositivo como Laboratório de Conhecimento. Deste modo, a metodologia empregada caracteriza-se como uma pesquisa de abordagem qualitativa de cunho exploratório. Conclui-se que ao tratar a Abordagem Triangular enquanto estratégia para a mediação cultural social e artística, possibilita-se o contato dos sujeitos com a arte a partir da experiência, da valorização do repertório cultural, e a reflexão sobre aspectos culturais e sociais.
O ensino das artes na cultura contemporânea: enfrentamentos e recriação das práticas docentes para re-existir no currículo em tempos de “reformas”
Authors: Bessa-Oliveira Marcos Antônio
Published: October 2024

O ensino de Arte sempre foi reformulado por meio de documentos de órgãos da educação – municipal, estadual ou federal. Recentemente o ensino de Arte enfrenta reformulações que parecem não se valer, na realidade, das práticas docentes nas escolas nas disciplinas de Arte. Desta vez a BNCC (2017) está promovendo reformas como um desmonte da Área de Arte no currículo. Logo, devemos promover enfrentamentos e recriar alternativas que resistam às proposições de documentos “reformadores” que interferem nas práticas docentes sem “tomar conhecimento” da realidade escolar brasileira: onde falta quase tudo e sobram leis que não representam a realidade da Educação, dos Corpos e dos Movimentos das instituições escolares no Brasil. A partir de discussões epistemológicas descoloniais fronteiriças que tratam da prática docente, da formação de professores e do ensino de Arte atuais, pretende-se apontar estratégias de atuação e de consciência epistêmica que resistam às imposições dos sistemas que (de)formam a realidade sociocultural, econômica e educacional brasileiras. Para, com isso, enquanto professores de Arte, evidenciar que é preciso re-existir para continuarmos existindo no currículo da Educação no Brasil.
Mortalidade por câncer de estômago no nordeste brasileiro, brasil, 2002 – 2019: um estudo ecológico
Authors: Lopes Maria Eduarda Bezerra , Cavalcante Jéssica Beatriz Pachêco , Oliveira Allanna Stephany Cordeiro de , Almeida Ruth Araújo de , Silva Allan Batista
Published: October 2024

Objetivo: analisar a distribuição e taxa de mortalidade por câncer de estômago nos estados da Região Nordeste do Brasil, entre os anos de 2002 e 2019. Métodos: trata-se de um estudo ecológico com abordagem quantitativa, realizado com base nos dados registrados no Atlas On-line de Mortalidade por Câncer disponibilizado pelo INCA e na base de dados do IBGE. Resultados: o estudo evidenciou que durante o período de 2002 a 2019 foram notificados 51.297 casos de Câncer de estômago no Nordeste, com média de cerca de 2.850 casos ao ano. Destes casos, observou-se maior distribuição de óbitos nos estados do Ceará, Bahia e Pernambuco, afetando principalmente pessoas do sexo masculino. Considerações finais: diante do crescente número de óbitos de câncer de estômago entre 2002 e 2019, faz-se necessário a criação de políticas que incentivem a prevenção, diagnóstico precoce e tratamento para as neoplasias gástricas nas áreas e populações de maior risco.
Aplicação do método Servqual em uma cooperativa de saúde: uma análise da qualidade em serviços
Authors: Silva Deoclécio Junior Cardoso da , Tontini Julia , Malheiros Michel Barboza , Polacinski Edio , Godoy Leoni Pentiado
Published: October 2024

O setor de serviços possui papel significativo na economia brasileira, sendo responsável por cerca de 73% do PIB nacional (IBGE, 2017). Nesse contexto, a qualidade dos serviços tem sido difundida, em virtude de ser imprescindível que as empresas prestadoras de serviços proporcionem a seus clientes qualidade ideal, suprindo suas necessidades. Partindo dessa premissa, este estudo objetivou analisar a qualidade dos serviços em uma cooperativa de saúde localizada no extremo Sul do Brasil. Para tanto, realizou-se uma pesquisa quantitativa e exploratória, com a aplicação de um questionário. Quanto à análise dos dados utilizou-se a escala SERVQUAL, para mensurar a qualidade dos serviços. Sendo assim, os resultados obtidos com o SERVQUAL demonstraram que todas as dimensões da qualidade estavam fora do ideal, sendo necessário gerar melhorias por parte da cooperativa.
Media Pembelajaran Interaktif Berbasis Mentimeter untuk Pembelajaran Teori Musik Anak Berkebutuhan Khusus
Authors: Rr. Diana Insyafari
Published: October 2024

Technology in education continues to evolve, offering new opportunities for more interactive teaching and learning, especially for children with special needs. One innovation that can be utilized is Mentimeter, an interactive tool that allows teachers and students to engage in a dynamic learning environment. This article discusses the implementation of Mentimeter as an interactive learning medium in teaching music theory to children with special needs. The objective of this research is to examine the effectiveness of Mentimeter in enhancing students' understanding and engagement with music theory material. Using the classroom action research method, this study involved 20 students from SLB Negeri Surakarta with various special needs who participated in music lessons over a period of three months. The results of the research indicate that the use of Mentimeter increased students' active participation and facilitated a better understanding of the material.
Analisis Pengelolaan Keuangan Objek Wisata Hutan Pinus Buntudatu Kecamatan Mengkendek Kabupaten Tana Toraja
Authors: Zhuhaeny Zhuhaeny  , Adriana Madia Marampa  , Stefani Marina Palimbong
Published: October 2024

This study aims to analyze how the form of financial management is implemented in the Buntudatu Pine Forest Tourism Object. The type of research used is qualitative research with a descriptive approach. With data collection methods, namely interviews, documentation, and observation. The results of the research obtained are that financial management at the Buntudatu Pine Forest Tourism Object has been implemented but has not been maximized where planning has been carried out by the tourism object manager by holding village meetings in order to minimize expenses in order to get profits. The recording system is carried out every day manually using books or paper to record all income and expenditure transactions. And financial reporting has not been implemented because the knowledge possessed is still minimal, but the manager has made a year-end accountability report. Meanwhile, control has been carried out by holding evaluation meetings every month, to achieve a certain goal.
Analisis Laporan Keuangan Berdasarkan Metode Common Size Pada PT. Sentra Food Indonesia, Tbk
Authors: Debora Rayo  , Helba Rundupadang  , Agustinus Mantong
Published: October 2024

Analysis of Financial Statements Based on the Common Size Method at PT. Indonesian Food Center, Tbk. This study aims to determine and analyze the composition of assets, debts and capital based on the general size of the financial statements of PT. Sentra Food Indonesia, Tbk in 2018-2020. This type of research is descriptive quantitative research. The data collection procedure used in this study is through documentation in the form of financial reports obtained from the official website of the Indonesia Stock Exchange, namely www.idx.co.id. The results of the study show that in terms of the common size from the balance sheet, PT Sentra Food Indonesia, Tbk. who allocated funds for assets in 2018-2019 mostly from their own capital thereby revealing a stronger financial condition of the company, while in 2019-2020 most of the funds for assets came from debt. Common size in terms of profit and loss statement, PT Sentra Food Indonesia, Tbk. In 2018-2019 there was an increase in net profit so that it can be seen that the company managed to increase sales better, while in 2019-2020 net profit decreased due to decreased sales.
Pengaruh Penggunaan Media Sosial Instagram, Word Of Mouth dan Daya Tarik Wisata Terhadap Keputusan Berkunjung Wisatawan Pada Objek Wisata Sawah KalimbuangKabupaten Toraja Utara
Authors: Esmeralda Esmeralda  , Althon K. Pongtuluran  , Chrismesi Pagiu
Published: October 2024

The purpose of this study was to find out whether social media Instagram, word of mouth, tourist attractions influence the decision to visit the Kalimburan Rice Fields Tourism Object. Data collection process techniques from this study are: Observation and Questionnaire. The analysis technique uses multiple linear regression tests. The results of the partial test (t test) show that the social media variables Instagram, word of mouth, tourist attraction influence the decision to visit the Kalimburan Rice Field Tourism Object. Meanwhile, the results of the simultaneous test (F test) showed that the social media variable Instagram, word of mouth, tourist attraction had an effect on the decision to visit the Kalimburan Rice Fields Tourism Object.
Optimalisasi Digital Marketing di Marketplace
Authors: Alfina Maulida  , Dwimei Ayudewandari Pranatami
Published: October 2024

This Real Work Lecture (KKN) program aims to improve the digital marketing skills of MSME players in Sekaran Village, Gunungpati District, Semarang City. With technological developments, digital marketing has become important to expand market reach and increase sales. This activity includes training and seminars on the basics of digital marketing, choosing the right marketplace, optimizing seller accounts, as well as implementing SEO and decorating online stores. Participants are also invited to practice directly creating an account, uploading products, and optimizing their shop. The results of the activity showed an increase in participants' knowledge and skills in digital marketing, as well as an increase in traffic and sales on their marketplace accounts. This program has succeeded in having a positive impact on MSMEs, helping them utilize technology to achieve greater business success
GERENCIAMENTO DE ESTOQUES DE MATÉRIAS-PRIMAS NA PRODUÇÃO DE OVOS CAIPIRAS: UM ESTUDO DE CASO EM UMA GRANJA AVÍCOLA NO INTERIOR DA BAHIA
Authors: Santos Carlos Eduardo Brito , Santos José Carlos Ferreira , Santiago Carneiro Etiene
Published: October 2024

O presente artigo tem como objetivo geral compreender o gerenciamento de estoques de matérias-primas em uma granja avícola e como objetivos específicos identificar as estratégias utilizadas pela granja na gestão de estoques e analisar as condições do armazenamento das matérias-primas, compreendendo assim os níveis de eficiência do modelo de gestão de suprimentos vigente no empreendimento em questão. Para cumprir com os objetivos do trabalho, optou-se por uma pesquisa de abordagem qualitativa, na forma de um estudo de caso. Como método de coleta de dados, utilizou-se um questionário com questões abertas aplicado aos gestores de uma granja avícola localizada no município de Serrinha- BA, partindo do pressuposto de pequenos empreendimentos solidários similares ao pesquisado não possuem um gerenciamento de estoques adequado, fato que acarreta uma série de questões de ordem econômica e financeira. Os resultados demonstram a necessidade de implementação de modelos mais eficazes de gestão de estoques, com foco na produção mais estável, contribuindo assim para sua permanência no mercado da avicultura.
Worldwide Recessions and Herding Behaviour: A Comparative Analysis of Three Countries
Authors: Suyadi Nurtantyo Pratomo , Husodo Zaäfri Ananto
Published: October 2024

The general suggestion that behavioral science plays a part in creating abnormalities within the financial sector has been studied and proposed many times in the past. This study aims to prove the existence of behavioral sciences, specifically herding behavior, in three countries with different market conditions: Indonesia (Emerging), Vietnam (Frontier), and the United States (Developed). We developed our methodology using quantile regression to study the existence of herding behavior, and our findings were as follows: (1) As expected, the US didn’t have any indication of a statistically significant herding presence; they do, however, indicate an insignificant presence of herding behavior in the post-covid period under bearish conditions (2) Vietnam does not indicate significant herding tendencies, (3) Surprisingly, Indonesia did not exhibit statistically significant herding presence, but both Indonesia and Vietnam exhibited the slight presence of herding behavior but still relatively insignificant.
The use of Virtual Reality in Medical Training
Authors:   Faculty of Medicine Kampala International University Uganda, Nyiramana Mukamurera P.
Published: October 2024

Virtual reality (VR) has become an increasingly important tool in medical training, offering immersive, interactive environments that provide unique opportunities for skill acquisition, education, and patient safety. Traditionally, medical education has relied on real-patient interactions, which can sometimes pose ethical challenges and risks. VR enables learners to practice clinical procedures in risk-free environments, enhancing skills such as surgery, anatomy recognition, and diagnostic interpretation. This paper investigates the history of VR in medical training, its benefits, challenges, and limitations, alongside examples of successful VR applications in healthcare education. As VR technology continues to advance, its potential to transform medical education is significant, offering a safe, affordable, and flexible method for improving healthcare outcomes. Keywords: Virtual reality, medical training, simulation, medical education, clinical skills, patient safety.
Cuidados de enfermería en un paciente con soporte hemodinámico mediante membrana de circulación extracorpórea, a propósito de un caso
Authors: Senra Alonso Sheila
Published: October 2024

Introducción: En los últimos años, ha aumentado gradualmente el uso de dispositivos de soporte circulatorio como la Membrana de Oxigenación Extracorpórea. Esto se debe, entre otras cosas, al mayor grado de conocimiento y entrenamiento del equipo profesional encargado de su manejo. Dentro de este equipo, cabe destacar la función de la enfermería. En esta publicación, se expone un plan de cuidados realizado a un paciente, que, tras ser sometido a una intervención quirúrgica sobre la válvula mitral, sufre una disfunción biventricular severa, por lo que precisa de asistencia con Membrana de Oxigenación Extracorpórea Veno-Arterial.
Descripción del caso: Se realizó la valoración enfermera siguiendo el patrón de las catorce necesidades de Virginia Henderson, tras lo que se creó un plan de cuidados siguiendo la Taxonomía NANDA-NIC-NOC. Como diagnósticos principales se destacan Riesgo de infección, ya que son pacientes sometidos a numerosas técnicas invasivas. Riesgo de sangrado, es preciso la canulación de grandes vasos para la implantación de la Membrana de Circulación extracorpórea a lo que se le suman las alteraciones en la coagulación. Disconfort, cabe destacar la importancia del correcto manejo del dolor y la ansiedad, así como el papel fundamentad de la familia del paciente en este proceso.
Discusión: El manejo de un paciente portador de una Membrana de circulación extracorpórea precisa de un adecuado entrenamiento por parte del personal de enfermería implicado para poder atender a las necesidades específicas del mismo, así como de las posibles complicaciones que puedan aparecer durante el proceso.

Palabras Clave: Oxigenación por Membrana Extracorpórea, Enfermería de Cuidados Críticos, Terminología Normalizada de Enfermería, Atención de enfermería, Shock Cardiogénico.
Trombosis venosa en paciente portadora de marcapasos. Plan de cuidados individualizado
Authors: Solaz Ródenas Celia , Roselló Hervás Mónica
Published: October 2024

La trombosis venosa es la obstrucción parcial o completa del lumen de un vaso venoso causado por un trombo de fibrina. Esto provoca una reducción del aporte sanguíneo a los tejidos circulantes acompañada de una reacción inflamatoria.
Presentamos un caso de trombosis venosa profunda de extremidad superior tras la inserción de marcapasos definitivo por vena axilar izquierda en mujer de 77 años.
La paciente presenta dos factores más de riesgo protrombótico: un déficit de proteína S y una infección por Covid 19, que también podrían influir en el caso presentado, pero que descartamos tras la revisión bibliográfica. Concluimos que se trata de una trombosis venosa profunda secundaria, adquirida y provocada, ya que la causa principal del evento trombótico ha sido el implante del marcapasos.
Desarrollamos un plan de cuidados individualizado para el caso presentado. Se utilizaron los patrones funcionales de Marjory Gordon para llevar a cabo la valoración y resolución de los problemas de salud de la paciente, aplicando la taxonomía NANDA, NOC, NIC.
Es para el personal de salud, en general de gran importancia, conocer los factores involucrados en el desarrollo de este tipo de patología, así como su abordaje para diagnóstico, manejo y cuidados de enfermería más apropiados para esta complicación, teniendo en cuenta que es una complicación poco usual de la cual se cuenta con escasa información que respalde su adecuada evolución. En nuestro caso, fue determinante en su mejoría el uso de vendaje de compresión ortopédica.

Palabras Clave: trombosis venosa profunda, marcapasos, deficiencia de la proteína S, infección por el virus COVID-19, planes de cuidados.