bluuebunny/crossref_metadata_2025 huggingface dataset:
Circadian rhythm of carbohydrate metabolism in health and disease
Authors: Sorokin M. Yu. , Pinkhasov B. B. , Selyatitskaya V. G.
Published: May 2023

The article presents a review of the main circadian mechanisms regulating carbohydrate metabolism and their role in maintenance of energy homeostasis; the molecular genetic structure of the circadian system is also discussed. The role of adipose tissue and other organs and systems in the maintenance of circadian rhythm of carbohydrate metabolism, both in health and in obesity and diabetes, is highlighted. Particular attention is paid to diurnal rhythms of endocrine factors responsible for metabolic patterns of hormones such as cortisol, growth hormone and melatonin. Gender differences in the circadian regulation of energy and carbohydrate metabolism are also discussed, as well as their changes in different age periods. Article provides detailed review of the mechanisms of glucose utilization, reactivity of the pancreatic islets and peripheral insulin sensitivity shifts at different time periods of the day in people with normal body weight, android and gynoid types of obesity, both in women and men. Protective factors of energy metabolism circadian regulation structure preventing the development of diabetes mellitus and cardiovascular disease in individuals with so-called “metabolically healthy” obesity type are discussed. Article provides a review of various pathways of circadian rhythm disturbances, mechanisms of their development, as well as exogenous and endogenous factors leading to carbohydrate metabolic circadian rhythm misalignment, such as shift work, untiming of natural and artificial lighting, jet lags, sleep disorders. Represented data contribute to a new look at the pathogenesis of obesity and carbohydrate metabolism disorders in various types of obesity in men and women, that provides basis for searching for new effective methods of prevention and treatment of these conditions, elaboration of evidence-based diets and physical activity recommendations, as well as approaches to their medical treatment.
Prospective assessment of cytokines and regulatory proteins concentration in the tear fluid of POAG patients with various hypotensive effects after non-penetrating deep sclerectomy
Authors: Malisheva J. V. , Iureva T. N. , Volkova N. V. , Kursakova J. V. , Kolesnikov S. I.
Published: May 2023

The aim. To assess the dynamics of cytokine content in tear fluid of primary openangle glaucoma (POAG) patients at various terms after non-penetrating deep sclerectomy (NPDS) in relation to the functional state of the outflow tracts.

Material and methods. We carried out prospective examination of 65 patients with advanced stage of primary open-angle glaucoma after NPDS. Depending on the course of the postoperative period and the conditions for achieving the hypotensive effect of NPDS, all patients were divided into three groups: group 1 – with the optimal hypotensive effect; group 2 – with the conditional hypotensive effect; group 3 – with no hypotensive effect after NPDS. The intraocular pressure and the concentration of TGF-β, MMP-9, IL-6, IL-8, VEGF-A (121 and 165) in the tear fluid were studied using ELISA method in pre- and postoperative period. We studied the outflow tracts using optical coherence tomography and carried out ultrastructural analysis of filtering blebs tissue.

Results. In group 1, the minimum initial concentrations of IL-6, IL-8 and TGF-β in the tear fluid and their moderate increase in the postoperative period; high concentrations of MMP-9 at all stages and an increase in VEGF-A by 2 months after NPDS were registered. In group 2, there was a high level of VEGF-A in the tear fluid before and 2 months after NPDS, an increase in TGF-β, IL-6 and IL-8 in the tear fluid in the early period with their suppression in the late period, as well as an increase in MMP-9 in the early postoperative period. Group 3 had maximum concentrations of TGF-β and IL-8 in the tear fluid initially and in the early postoperative period, suppression of MMP-9 in the tear fluid 2 weeks after and of VEGF-A 2 months after NPDS.

Conclusion. Initially high concentrations of IL-6, IL-8, and TGF-β in the tear fluid and the suppression of MMP-9 and VEGF-A in the postoperative period contribute to the surgical failure of the NPDS.
Component composition of the body in children with chronic kidney disease according to the results of bioimpedansometry
Authors: Zavyalova A. N. , Lebedev D. A. , Novikova V. P. , Smirnova N. N. , Firsova L. A.
Published: May 2023

Body composition reflects the dynamic processes in a child’s development. The recommended restrictive diets for patients with advanced chronic kidney disease (CKD) contribute to a high risk of sarcopenic muscle wasting as diagnosed by bioimpedancemetry.

The aim of the study. To assess BMI and body composition in children with CKD, to identify features of body composition in patients with different BMI Z-score values.

Materials and methods. The physical development of 110 children with CKD of different stages was assessed. Patients were divided into two clusters: Group 1 (92 children) with BMI from 10.95 to 21.5 kg/m2, BMI Z-score did not exceed +2.0 (without obesity); Group 2 (18 children) – BMI from 24.11 to 37.2 kg/m2, Z-score BMI – more than +2.0 (obese). All underwent bioimpedancemetry, the proportion of fat and active cell mass was assessed. The comparison was carried out by nonparametric statistics methods.

Results. Changes in body composition were revealed: children without obesity had severe protein-energy deficiency in 7 cases (7.6 %). The difference in the proportion of fat mass in children of different groups, Me [Q1; Q3]: Group 1 – 18.00 % [14.00; 22.00], Group 2 – 35.00 % [21.98; 41.00], (Mann – Whitney U-test: U = 279.5, p = 0.00001). In Group 1, the active cell mass was 53.50 % [51.00; 56.00], in Group 2 – 41.50 % [39.00; 47.00] (U = 174.5, p = 0.000001), there were no significant differences in other parameters of bioimpedancemetry.

Conclusions. The proportion of active cell mass is lower in overweight children, with a significant predominance of the proportion of fat mass, which indicates the depletion of protein reserves due to their redistribution and possible insufficient alimentary intake in advanced stages of CKD.
High sleep reactivity: clinical, psychological and polysomnographic features
Authors: Zabroda E. N. , Gordeev A. D. , Amelina V. V. , Bochkarev M. V. , Osipenko S. I. , Korostovtseva L. S. , Sviryaev Yu. V.
Published: May 2023

Background. The model of sleep reactivity to stress considers sleep reactivity to stress as a link in the pathogenesis of insomnia disorder – the degree to which stress disturbs sleep, which manifests as difficulty in initiating and maintaining sleep.

The aim. To study clinical and psychological features as well as subjective and objective sleep indexes of subjects with high level of sleep reactivity to stress.

Materials and methods. The psychological status, subjective indexes of sleep and sleep reactivity to stress according to Ford Insomnia Response to Stress Test were studied among 18–75 year-old subjects without significant sleep disturbances and patients with chronic insomnia. Polysomnography was performed for objective evaluation of sleep parameters.

Results. It was found that individuals with high levels of sleep reactivity to stress were characterized by high levels of anxiety, restlessness, and neuroticism. According to results of Pittsburg questionnaire, a lower quality of sleep was revealed. These findings were correlated with objective indexes of sleep according to polysomnographic studies: less deep sleep and its lower efficiency due to sleep disturbances.

Conclusions. Individuals with high sleep reactivity to stress are characterized by greater anxiety combined with subjective and objective sleep disturbance like insomnia type.
Assessment of the effectiveness of restrictive epidemic control measures using original models of cellular automaton
Authors: Karateev A. Yu.
Published: May 2023

Background. The ongoing COVID-19 pandemic, the human casualties caused by it, and the possibility of new epidemical threats make the search for effective countermeasures actual. One of the most effective tools, as the experience of the COVID-19 pandemic has shown, is restrictive measures of various types, which are especially significant with medical countermeasures being unavailable or insufficient. At the same time, the topic of restrictive measures and their mathematical modeling, especially given its importance, is not sufficiently disclosed in the scientific literature.

The aim. To determine the possibility of assessing the effectiveness of restrictive epidemic control measures using original models of cellular automaton with intercellular boundaries.

Methods. To determine the impact of restrictive measures on the dynamics of the daily increase in infected people, an original cellular automaton with intercellular boundaries was developed, which makes it possible to simulate epidemic control measures of varying stringency. In the simulations carried out using the Monte Carlo method with subsequent statistical processing, we studied the impact of restrictive measures of varying stringency on the number of infected people, the duration of the epidemic, and the quality of forecasting. The final series of experiments simulated the spread of the COVID-19 virus in Germany in the first half of 2020.

The results show that even a simple cellular automaton model with boundaries successfully describes the course of the epidemic and allows us to assess the effectiveness of restrictive measures. The dependence of the daily increase in infected people on the stringency of measures is presented; it is shown what characteristics of the population can influence this dependence. It was found that the measures of medium stringency (40–50 % according to the Stringency Index) have the least predictable effect; they can cause both rapid localization of the focus and the spread of the epidemic to a large part of the population. Weak and strong measures give a more predictable effect.

Conclusion. Cellular automaton models with intercellular boundaries have great potential for modeling the impact of restrictive measures on the course of an epidemic, making it possible to predict the dynamics of infected people based on the population data and the restrictive measures being introduced.
The first TIPS surgery performed in the Udmurt Republic in a young patient with secondary biliary cirrhosis
Authors: Styazhkina S. N. , Zaitsev D. V. , Bagautdinov A. L. , Sharafutdinov M. R. , Antropova Z. A. , Zaripov I. I. , Kamalov M. I.
Published: May 2023

Treatment of patients with iatrogenic injuries of the biliary tract is the most difficult and important section in hepatobiliary surgery. When analyzing the causes, it was found that in 70–94 % of cases this type of injury is observed during cholecystectomy. We present a rare clinical case of the development of secondary biliary cirrhosis due to iatrogenic trauma of the biliary tract. This injury caused long-term suffering for the patient due to the further development of complications of cirrhosis, specifically of portal hypertension. The latter caused repeated recurrent profuse bleeding from varicose veins of the esophagus. The use of a minimally invasive transjugular intrahepatic portosystemic shunt procedure for the first time in the Udmurt Republic was of particular relevance in solving this problem. This procedure has become a key one in solving the abovementioned problems and will become the preventive measure for the cirrhosis progression in the future. It is also important to focus on prophylactic measures aimed at preventing iatrogenic injuries of the biliary tract, as this problem can cause irreversible complications. Prevention should include adequate examination and visualization of the bile ducts and gallbladder before surgery, their careful mobilization, compliance with the rules of operation with electrosurgical instruments, as well as the use of additional minimally invasive techniques such as choledoscopy, cholangiography and intraoperative ultrasound. Besides that, all manipulations should be carried out under strict control and clear visualization of instruments and anatomical structures of organs. The article provides a detailed description of the technique of transjugular intrahepatic portosystemic shunt surgery, as well as presents X-ray images obtained during this operation.
Features of the integration of two-layer metal knitwear made of titanium nickelide during the replacement of a thoracoabdominal defect in the experiment
Authors: Topolnitskiy E. B. , Shefer N. A. , Marchenko E. S. , Fomina T. I. , Mikhed R. A. , Tsydenova А. N. , Garin A. S.
Published: May 2023

The aim of investigation was to study experimentally the morphological features of tissue integration of two-layer titanium nickelide (TiNi) knitwear when replacing thoracoabdominal defects.

Materials and methods. The experiments were carried out on 40 Wistar rats. The experimental animals were divided into two comparison groups: in Group A (n = 20) the defect was replaced using a two-layer knitted tape made of TiNi, in Group B (n = 20) a polypropylene mesh implant was used. The technique of the operation and the peculiarities of keeping the animals did not differ. Animals were taken out after 14, 30, 60 and 90 days of experiment. The macroscopic structural features at the site of implant fixation to tissues and at the sites of contact with underlying organs were studied, and the inflammatory process was assessed. The histological and electron microscopic study was carried out with an assessment of the features of tissue integration through the mesh structure of knitwear.

Results. Thirty days after the surgery in four cases of Group B the appearance of the chest wall deformation at the site of implant fixation was noted, in one case the deformation site was located along the lateral edge of the abdominal wall. Among the animals of Group A no such changes were recorded. The histological and electron microscopy examination revealed that the porous structure of the TiNi wire, as well as the biomechanical and biochemical properties of the two-layer metal knitwear, ensure optimal integration of the endoprosthesis in the body tissues, forming an elastic frame close to natural. In Group B, on the contrary, the reaction of the body caused by the implanted polypropylene prosthesis was characterized by more pronounced fibrosis, and tissue integration through the mesh structure of the implant was not observed.

Conclusion. Two-layer TiNi knitwear in the replacement of complex structures of the thoracoabdominal zone showed promising results, which opens up prospects for further clinical research.
Epidemiological manifestations of tuberculosis infection in the Omsk region: dynamics and trends
Authors: Kostyukova I. V. , Pasechnik O. A. , Mokrousov I. V.
Published: May 2023

Background. Tuberculosis (TB) infection remains relevant as one of the leading public health problems in Russia.

The aim. To characterize the dynamics and trends of epidemiological manifestations of TB infection in the Omsk region.

Materials and methods. An observational descriptive-evaluative epidemiological study was carried out in the Omsk region from 2009 to 2021. The data available in the Federal statistical observation forms NN 7, 8, and 33, and results of the bacteriological study of patients with respiratory TB were analyzed.

Results. In the Omsk region, an improvement in the epidemiological situation was observed from 2009 to 2021. It was associated with a decrease in TB prevalence by 3.7 times (from 325.6 to 86.7), mortality – by 5.8 times (from 21.1 to 3.6), incidence – by 2.7 times (from 130.7 to 48.4 per 100,000). At the same time, proportion of microscopy/culture-positive patients infected with multidrug-resistant Mycobacterium tuberculosis strains increased from 9.2 to 29.8 % among all patients, and from 15.5 to 30.6 % among newly diagnosed patients. There was a trend towards an increase in the number of cases with primary extensive drug resistance of M. tuberculosis. The incidence of tuberculosis associated with HIV infection has increased 10 times and reached 15.6 per 100,000 population.

Conclusions. In the Omsk region, there is a change in the structure of M. tuberculosis strains with a predominance of multiple and extensive drug resistance along with decrease in TB incidence and mortality. New approaches are needed to organize the system of epidemiological surveillance and control of TB infection.
The role of circulating miR-19b miRNA in predicting the outcome of COVID-19
Authors: Shkurnikov M. Yu. , Kolesnikov S. I.
Published: May 2023

Background. MicroRNAs are short (20–22 nucleotides) non-coding RNAs that can posttranscriptionally regulate gene expression and are considered a regulator of the innate immunity system. Previously, many papers were published on the prediction of the interaction of the single-stranded (+)RNA virus SARS-CoV-2 with human microRNAs, as well as on the profile of circulating microRNAs in patients with COVID-19 of varying severity. However, no works are analyzing the possible contribution of miRNAs circulating in blood plasma to the severity of COVID-19.

The aim. To study the features of the blood plasma microRNA profile of patients with different severity of the new coronavirus infection COVID-19 and to evaluate the possibility of microRNA interaction with the SARS-CoV-2 genome.

Materials and methods. The results of NGS sequencing of plasma miRNAs of 3 recovered and 8 deceased patients with a highly severe form of COVID-19 were studied. Differentially presented microRNAs were determined using bioinformatics methods, and their binding sites with the SARS-CoV-2 genome were predicted.

Results. This study demonstrates that in patients who have recovered from a highly severe form of COVID-19, the level of hsa-miR-19b-3p in the blood plasma is significantly increased. This microRNA makes up about 1.5 % of all circulating microRNAs and can bind to SARS-CoV-2 regions encoding proteins that suppress intracellular immunity mechanisms (NSP3, NSP9). In addition, this miRNA can stimulate the functional activity and proliferation of cytotoxic T-lymphocytes, one of the critical components of acquired cellular immunity against SARS-CoV-2.

Conclusion. The results of the study can be used in the development of antiviral drugs based on RNA interference, as well as in the development of predictive test systems to optimize the tactics of treating patients with COVID-19.
Thyroid status and TNF-alpha in post-reproductive women with COVID-19 and 12 months after the disease
Authors: Semenova N. V. , Kolesnikov S. I. , Vyrupaeva E. V. , Sholokhov L. F. , Rychkova L. V. , Petrova А. G. , Akhmedzyanova M. R. , Darenskaya M. A. , Kolesnikova L. I.
Published: May 2023

The aim. To assess the thyroid status and its relationship with tumor necrosis factor alpha (TNF-alpha) in post-reproductive women in the acute phase of the COVID-19 of moderate course and 12 months after the disease.

Materials and methods. 85 women aged 45 to 69 years were divided into groups: women without COVID-19, not vaccinated, with no antibodies to COVID-19 (IgG) – control group (n = 15); women in the acute phase of COVID-19 of a moderate course, accompanied by pneumonia – main group (n = 57); patients from the main group who agreed to be examined 12 months after having COVID-19 (n = 14); women with IgG in blood who deny any symptoms of COVID-19 in the last 12 months – asymptomatic COVID-19 (n = 13). Using hormone replacement therapy and the presence of thyroid disease in history were the exclusion criteria from the study.

Results. 75.4 % of patients with COVID-19 had euthyroidism, 12.3 % had subclinical hyperthyroidism. An increase of free thyroxine (free T4) level in women with COVID-19 as compared to the control group (p = 0.004) and the group with asymptomatic COVID-19 (p = 0.054) was found. There was no statistically significant difference in the level of thyroid stimulating hormone between the groups. The level of C-reactive protein in women with COVID-19 was naturally higher as compared to the control group (p = 0.009) and the group of asymptomatic patients (p = 0.001). A lower TNF-alpha level was found in the group of patients without clinical signs of COVID-19 as compared to the control group (p = 0.007) and the group with COVID-19 (p = 0.00007). The analysis of correlation relationships revealed a positive correlation between of free T4 and TNF-alpha levels in women with COVID-19 (r = 0.38, p = 0.004).

Conclusions. The moderate course of COVID-19 in the post-reproductive women is associated with an increase of free T4 level, which positively correlates with TNF-alpha level. Twelve months after COVID-19, thyroid status in women remains at the level of the acute phase of the disease.
The enhanced recovery program in urology. Systematic review and meta-analysis
Authors: Vorobev V. A. , Beloborodov V. A. , Tukhiev A. R.
Published: May 2023

A systematic review and meta-analysis of data on the problem of enhanced recovery in urology was performed. Inclusion criteria – clinical trials of the enhanced recovery program in urology.

The aim of the study was to assess the significance of the enhanced recovery program (ERP) in the provision of surgical care in the “urology” profile.

Materials and methods. The systematic review was performed according to the guidelines for the presentation of systematic reviews and meta-analyses by PRISMA. The registration number in the international system Prospero was received (CRD42022358982). The review included 364 studies. Studies in urologic oncology were excluded from the meta-analysis. The meta-analysis included 15 studies involving 2293 subjects. A comparison was made between the application of ERP and the standard treatment protocol.

Results. The use of ERP leads to an expected two-fold reduction in the duration of postoperative length of hospitalization (OR = –1.96; 95% CI: –2.56÷–1.36; p < 0.00001). The reduction in the duration of hospitalization with the use of ERP in urology does not lead to the increased risk of readmission or re-operation (p = 0.35). The risks of developing postoperative complications ≥ Class 2 by Clavien – Dindo classification were comparable in both groups (p = 0.13). The use of ERP increases the expected success of the treatment by 1.74 times (OR = 1.74; 95% CI: 1.08–2.79; p = 0.02). With the use of ERP in reconstructive urology, a significantly lower risk of complications was established (p = 0.02).

Conclusion. The ERP program allows you to reduce the time and cost of treatment, reduce the likelihood of re-hospitalization and achieve better treatment results. The use of ERP is not accompanied by increased risk of complications > Class 2.
Methods of physical rehabilitation of elderly people for the prevention and treatment of sarcopenia
Authors: Pleshchev I. E. , Achkasov E. E. , Nikolenko V. N. , Shkrebko A. N. , Ivanova I. V.
Published: May 2023

The aim of the review is to analyze the prevalence of sarcopenia in the elderly age group, the causes of its occurrence, and to present modern methods of prevention and physical rehabilitation. The study focuses on the relationship between exercise, training effects and physiological mechanisms, as well as the safety of various types of strength, anaerobic and multimodal training, which have a positive impact during the prevention and rehabilitation treatment of sarcopenia. Literature reviews, meta-analyses, and original studies are included that focus on older people in all settings, using validated assessment tools and methods. A literature search was conducted in four electronic databases – PubMed, Cochrane Library, Scopus, Springer, for the period from 2012 to June 30, 2022. There were no restrictions on the language bias of the publication. Search strategy. The keywords used to define the terms of participation in the review are “older/advanced age”, “sarcopenia” and “sarcopenic obesity”. Articles were included if they met the following criteria – cohorts with mean or median age ≥ 60 years and any of the following definitions of sarcopenia: European Working Group on Sarcopenia in the Elderly (EWGSOP), Asian Working Group on Sarcopenia (AWGS), International Working Group on Sarcopenia (IWGS). To ensure comparability of interventions, the review included studies that were conducted for at least 8 weeks, and the distribution of patients by study design was randomized. Also, articles involving hospitalized patients are excluded.
IMPACT OF ECONOMIC CRIME ON THE SUSTAINABLE DEVELOPMENT OF THE STATE
Authors: Otinashvili Ramaz , Veshapidze Shota , Zoidze Gia
Published: May 2023

Purpose. The purpose of the paper is to study the impact of criminal business activities on public order and stability of the country. Methodology. The methodological basis of the research is the theoretical and philosophical foundations of the origin of criminal business, its economic reasons, economic crime, competition, institutions. Practical Value. Depending on the scale of distribution and the volume of sales, drug trafficking is considered to be one of the most important areas of criminal activity. Criminality is a complex synthesis of legal, social, economic, political, psychological and other factors. The science of the mentioned phenomenon and its causes under the name of criminology was developed in the second half of the 19th century. However, the views were expressed by those who thought about it much earlier. The relevance of the topic. The scientific novelty of the research can be discussed in relation to the modern scientific and historical situation of the development of this research problem in the scientific community. Based on this, it is new to generalize, analyze and study the challenges of foreign economic security. It is important to reveal the mentioned trends and to develop recommendations in the direction of overcoming and perfecting the new challenges of economic security. Practical implications. There is no lack of relevant sources in the world scientific literature on specific research issues of criminal business. At the same time, in the modern stage of globalization, in today's changed conditions, it is important to comprehensively examine the domestic and foreign economic security priorities of the country. Expected results of the study. To reveal the modern trends and priorities of ensuring the internal and external economic security of the country, to identify the existing challenges and to determine the optimal ways of overcoming them.
ECO-INNOVATION AS A BASIS FOR SUSTAINABLE DEVELOPMENT
Authors: Tomashuk Inna , Baldynyuk Vasyl
Published: May 2023

The purpose of the article is to substantiate the necessity of introducing ecological innovations into the activities of enterprises, to study the problems and prospects associated with the introduction of ecological innovations, and to make recommendations on increasing the ecologicalization of the activities of enterprises. Methodology. The work uses general and special scientific methods and techniques of cognition: methods of theoretical generalization, analysis, synthesis and grouping, logical-historical method, deduction and induction. It is pointed out that one of the means to ensure the balanced development of society is the introduction of ecological innovations in enterprises. This will contribute to the growth of economic well-being of business entities, ensure the competitiveness of their products, give an opportunity to enter the world market of goods and services, increase the level of environmental safety of the territory and the health of people living there. The results of the work show that the direct implementation of ecological innovations will ensure environmental responsibility of business, increase the efficiency of enterprises, increase consumer loyalty to products and, as a final result, high indicators of competitiveness of manufacturers while preserving the environment. Practical implications. Eco-innovations provide a gradual impact on sustainable development. Achieving the principles of sustainable development, refusing to achieve high rates of economic growth at the expense of future generations, stopping the processes of depletion of natural resources are possible only through the implementation of effective innovative policies based on greening. Value/originality. Environmental innovations should be aimed at solving tasks related to reducing the consumption of resources, controlling harmful effects on the environment, increasing the production of ecological products, reducing the costs of eliminating destructive effects of production activities. Such innovations will lead to a significant reduction in the negative impact of the economic activities of enterprises on the environment and will increase the efficiency of the use of resources, energy and materials. In addition, the ability to ensure the implementation of the waste management process will increase, which will contribute to the sustainable development of the enterprise in the long term.
Memórias da ditadura brasileira em “Um gosto amargo de bala”, de Vera Gertel
Authors: COSTA Margareth Torres de Alencar , RESENDE Joelma de Araújo Silva
Published: May 2023

Este artigo investiga as memórias da ditadura brasileira apresentadas por Vera Gertel em Um gosto amargo de bala, texto autobiográfico publicado em 2013 que apresenta a militância da autora na luta pela democracia do país. Vera Gertel herda dos pais esse desejo coletivo de mudar sua realidade; ainda na adolescência, começa a ler Marx e Engels, entra para a Juventude Comunista e sua militância segue, adentrando o período da ditadura militar. Ela recebia clandestinos, escondia armas, providenciava todo o suporte para os perseguidos, era a favor da luta armada e amiga de Marighella, que foi assassinado pelos militares. Coggiola (2001) é utilizado para apresentar o contexto histórico da época; Zinani (2010), Pollak (1989), Sarlo (2007), Figueiredo (2017) abordam as relações entre ditadura e memória; Seligmann-Silva (2000) e Dalcastagne (1995) escrevem sobre o trauma e a dor que permeiam o período retratado. Percebe-se que Vera Gertel tenta utilizar a escrita como catarse, um alívio para suas memórias traumáticas, porém, não consegue, pois estas trazem marcas que jamais serão esquecidas. E continuar vivendo, mantendo essas memórias vivas é uma forma de lutar contra esse esquecimento, fazendo com que não haja retorno de tempos tão dolorosos e difíceis, como foi na ditadura militar brasileira.
[Recebido em: 21 mai. 2021 – Aceito em: 18 jun. 2021]
Pendidikan Kesehatan Dengan Pendekatan Health Belief Model Meningkatkan Perilaku Perempuan Menopause Tentang Resiko Osteoporosis
Authors: Widjayanti Yhenti
Published: May 2023

Objective:   Menopausal women are at high risk for osteoporosis. Osteoporosis can be prevented by health behavior. Prevention efforts are strongly influenced by the results of a person's health beliefs.  Purpose of this study was to   analyze the influence of health education with a health belief model approach on the behavior of menopausal women on the risk of osteoporosis . Methods:  Design of this study  was a pre-experimental pre-posttest design. The research subjects were 44 postmenopausal women who met the inclusion criteria. This study used a simple random sampling technique. This study’s variables were health education,  knowledge, attitudes and actions of menopausal women on the risk of osteoporosis during menopause. Data collected by questionnaire and  be analyzed descriptively by the percentage and statistical test and  Wilcoxon signed rank test. Results: The results showed that before intervention was given 43.2% respondents had fair level of knowledge,29.5%  respondents had  poor and 27.3%, respondents had good knowledge,  56.8% respondents had negative attitude and 43.2% had  positive attitude. While adequate action 45.5 % had less,  31.8% had enough and 22.7% respondents had adequate action.  After getting the intervention with a good knowledge level of 61.4%, 34.1% fair and 4.5% poor, while positive attitudes were 84.1% and negative attitudes were 15.9%, for good actions 61.4%, enough 25.0 % and less actions 13.6%. The results of statistical tests using the Wilcoxon signed rank test obtained each p <α , α= 0.5, which means that there was an effect of health education with the health belief model approach with the behavior of menopausal women on the risk of osteoporosisConclusion:  Health education with a health belief model approach effective to increase  knowledge of menopausal women so that they can form a positive attitude so that they motivate them to do menopause prevention actions.
Analisis Potensi Kesiapsiagaan Masyarakat dalam Menghadapi Bencana Banjir
Authors: Adriani Sri Wahyuni , Anggraeni Zuhrotul Eka Yulis , Hidayat Nabil Mumtaz , Gufroniah Faridatul
Published: May 2023

Objective:  To analyze the potential for community preparedness in dealing with flood disasters. Methods:  This research was correlational study with a cross sectional approach. This research was conducted in the Suci Village area of Panti Sub-district on the basis that Panti District has been hit by floods, and Suci Village was an area that was quite severely affected by floods. The population in this study were the family, especially families who have family members belonging to vulnerable groups such as pregnant women, infants and toddlers, disabled, and the elderly totaling 312 families. Samples were taken with a stratified random sampling of 120 sampel. Data analysis used ordinal regression.Results:  The results show that the majority of the community's preparedness in dealing with flood disasters was not ready and the factors that influence community preparedness in dealing with disasters were knowledge and attitude, emergency planning, disaster warning system, and resource mobilization capacity.Conclusion:  Improve community preparedness in dealing with flood disasters by looking at the community potential was very important to do.
Hubungan VO2Max dengan Resiko Cedera pada Pemain Voli Amatir di Klub Bola Voli Jakarta
Authors: Agustiyawan Agustiyawan , Mailani Rena , Nazhira Fidyatul , Amsah Ailsa Nahda Ahnafa , Kesuma Aby Bima
Published: May 2023

Objective: to identify the relationship between VO2Max and risk of injury among volleyball playersMethods: this study used  a cross-sectional study on 26 male amateur volleyball players method with aged 15 – 18 years. VO2Max was recorded by cooper test and risk of injury was measured by Functional Movement Screen (FMS) Test.Results:  the result obtained that there is relationship the VO2Max and risk of injuries (p = 0.001). A negative  correlation was recorded between the VO2Max and risk of injuries (r = -0.723). Conclusion:  The concluded that there is a relationship between VO2Max and risk of injury on amateur volley players with  a negative correlation.
Pengaruh Pemberian Madu Terhadap Kadar Hemoglobin, Berat Badan Lahir Dan Plasenta Pada Ibu Hamil Dengan Anemia
Authors: Asli Kartika , Juwita Juwita , Muldaniyah Muldaniyah
Published: May 2023

One of the efforts made to prevent anemia in pragnancy  is to use local plants in the community, namely honey. In general honey is effective for producing energy, increasing endurance, and increasing stamina. Honey also contains vitamin C, vitamin A, iron (Fe), and vitamin B12 which functions as the formation of red blood cells and hemoglobin. This study aimed to assess the difference between the intervention group Honey + Fe and the dick Fe group by measuring Hemoglobin levels, birth weight and placenta in pregnant women with anemiaMethods: This research is a quantitative study with a type of quasi experiment research. A sample of 46 people was selected by purposive sampling.Result: The results showed a significant difference in hemoglobin levels between the intervention group Honey + Fe (mean: 11.86 ± 0.94) and the Fe control group (mean: 10.16 ± 1.05) with a value of p = 0,000 (<0,05). The same was found in the measurement of Birth Weight showing a significant difference between the intervention group Honey + Fe (mean 3030 ± 495.53) and the Fe control group (mean 2521 ± 390.75), with a p value: 0,000 (<0.05 ) In contrast to the results of placental weight measurements, no significant differences were found between the intervention group Honey + Fe (mean 520 ± 43.37) and the Fe control group (mean 504 ± 47.65), with a p value: 0.250 (>0.05) .
True One Cell Chemical Analysis in Cancer Research: A Review
Authors: Reyes Karen , Verbeck Guido F.
Published: May 2023

True One Cell (TOC) analysis Is becoming highly critical for functional studies of cancer cells. This is partially because it is the only form of analysis that provides an avenue for studying the heterogeneity and cell-to-cell variations of individual cancer cells, thus providing unique insight into complex regulatory processes that govern TOC functions within a tumor. Additionally, true one cell techniques are playing an increasingly important role in current attempts to implement TOC metabolomic and proteomic studies, as well as emerging attempts to spatially resolve TOC information. In this review we provide a brief overview of the basis of the field and discuss its applications in TOC metabolomics and proteomics.
Der klagende Achill
Authors: Grütter Oliver
Published: May 2023

This essay focuses on Friedrich Hölderlin’s elegy Achill (c.1799), one of the earliest texts in which the author reacts to the separation from Susette Gontard. While previous works have emphasised the reference of this elegy to Hölderlin’s translation from Homer’s Iliad, it has been overlooked that the lamenting Achill is based on elegiac models of Latin literature (Propertius, Ovid), which Hölderlin was familiar with partly from school and partly from journals. By tracing the conception of an elegiac Achilles, the article sheds light on Latin substrates in Hölderlin’s poetry.
Google Translate Application for Simple Writing
Authors: Fidinillah Mildan Arsdan
Published: May 2023

The common problem in English teaching to a group of Indonesian speakers is that the group has difficulty understanding to an English topic. Such as in tenses, traditionally most teachers have done their best to explain in simple English and provide numerous examples. There's nothing wrong with this approach. However, as many Indonesian-speaking English teachers probably know, it can be helpful to quickly explain the concept in Indonesian. Then the lesson can turn back to English. Consequently, it wastes time and not effective, a solution should be found. One of the solutions is the Google Translate where Google Translate offers the most powerful, free online translation tools available. This English teaching article focuses on using Google Translate to help out in difficult situations, as well as provide ideas on how to use Google Translate in class in lesson plans. This research tries to provide and share the strength and weaknesses of Google translate tool for writing learning. This research took some students from seventh semester of UNINDRA students as sample.  The methodology used was descriptive. This research took time for about four (4) months. The findings of this research point out that many people are helped by the benefit of the Google Translate application. Despite the weaknesses of it, they believe that the results of the translation are accurate as long as they revise the translations manually.
Chaining The Words Activity on Teaching Writing of Affixes on Legal Document: A Morphosyntax Perspective
Authors: Kusumawardhani Paramita , Syihabuddin Syihabuddin
Published: May 2023

The research aims to analyze the use of chaining activity on teaching writing of affixes on legal document. Language is used to communicate each other, both written and spoken, to ease the audiences so it can be understood when the first time they read or hear it. On legal document, it should be simplified in written, used appropriate words and sentences structures, and presented clearly and logically. Language is also related to writing, of Morphology and Syntax that is in line with affixes. The right form of writing in Morphosyntax on legal document can ease both the readers and hearers when they have legal problems, so the appropriate actions can be taken. Morphosyntax is the combination of Morphology and Syntax. Morphosyntax studies about how words are formed and combined with structures into a good sentence. The method used was qualitative method to give the understanding about chaining the words in improving the writing skill and connecting the affixes to the base word especially in English legal document. The legal document was used as the research instrument. The participants of the research were the 1st semester of accounting students at University of Bina Sarana Informatika. The result of the research is there are some affixes, as the Morphology aspects, commonly used on the legal document, the affixes are: -ance, -al, -ence, -er, -ing, -ment, -or, etc. For Syntax aspects, there are grammar, noun, verb, adjective, adverb and preposition found on the legal document.
Sustaining TBLT during Online Learning: The Role of EFL Teacher Agency
Authors: Birrina Dias Fatatin , Emaliana Ive
Published: May 2023

While task-based language teaching (TBLT) is among the most preferred methods for teaching foreign languages, it has not received enough study to be empirically verified in the English as a Foreign Language (EFL) classroom. Few studies have looked into instructors' reactions towards TBLT in the setting of Indonesian college English. This study contributes to closing the gap by studying EFL teachers' perspectives of TBLT and evaluating the present use of TBLT in online learning. Data from classroom observations, interviews, and course materials were triangulated to give a descriptive synthesis of teacher participants' experiences with TBLT instruction. The data analysis indicated that the teacher displayed proactive and reactive agencies in overcoming the conflicts in the instructional activity system via teaching as both learning and adaptation. A variety of mediational elements were revealed to account for their agency. In order to influence teachers' adoption of task-based language teaching, the study emphasizes the significance of teachers' shared attitudes regarding the usefulness of TBLT, curricular change, and institutional support. The article finishes with a discussion of the practical implications of the findings of this small-scale study on how to facilitate successful application of TBLT during emergency remote teaching in Indonesia.
Moodle-Based Flipped Learning-Model to Increase Basic Translation Skills and 21st Century Skills
Authors: Purwanto Andri , Rasyid Yumna , Anwar Miftahulkhairah , Mayuni Ilza
Published: May 2023

Developing Moodle-based flipped learning model and integrating it with collaborative i-tool SmartCAT is one of the greatest challenges in Translation courses. Product validation is carried out by translation, Flipped Learning, instructional design and Learning Management System experts. To obtain expert consensus regarding the validity of the developed hypothetical model, the Delphi technique is used, namely the conclusion of the results of various expert opinions that are collected, searched for points of similarity, and summarized so that it becomes a common consensus. The consensus of experts includes the following aspects: 1) identification of problems through needs analysis, 2) priority determination, namely determining the type and manufacture of the product, 3) determining program objectives, and 4) determining solutions to solve problems. The next stage is to try it out on 10 lecturers and 60 students in the Translation course in the English Education Study Program. This trial was used to determine the impact of Flipped Learning and the subject’s perception of the application of the product in a lecture activity. The conclusion of the consensus results of the validity of the experts and the perception of the subject in this study were analyzed by the percentage method, while the determination of the impact of learning with the average difference test of the subject’s value. This research is expected to have a positive impact on Moodle-based Flipped Learning through the developed product, which can significantly improve students’ Basic Translation Skills and Twenty-First Century Skills.
The Stories of Three EFL College Students in East Java Universities amid the Covid-19: EFL Online Learning Process
Authors: Aziz Abdul , Sugianto Haris
Published: May 2023

The Covid-19 pandemic has also been felt by the world of education, especially in Indonesia. All parties involved in schooling are unprepared to handle this rapid outbreak. Distance learning in the network (online) is a new thing for both teachers and students themselves. Through the use of online applications, university lecturers in Indonesia continue to carry out their teaching duties by interacting online with students. The interactions are by uploading lecture material into the online application, giving assignments, online discussions, and reviewing the learning process. This research presents the results of an interview study with three English language education students from university in Indonesia about how their perceptions of their online learning experiences during the Covid-19 pandemic. This research presented as an inquiry case study that looks at how participants position themselves in connection to the phenomena. The results of this research show that online learning carried out in an effort to prevent the spread of Covid-19 is good to do as an alternative during social distancing. The Covid-19 outbreak makes us have to limit social interaction to break the chain of transmission. In addition to the learning process and maintaining the interaction between lectures and students, online learning is a good idea because it gives students new knowledge and experience about technology, particularly online learning applications. Technology has been crucial in the teaching of English since it makes the creation and the use of electronic learning tools considerably simpler where students can get to know various online applications and how to use them. However, there are some issues that need to receive special attention, such as the instability of the internet network and economic factors. The result of this research will become as an input11 for lecturers and institutions in carrying out this online learning process so that it continues to run optimally.
Linguistic Landscape Projects as English Teaching and Learning Resources: A Review
Authors: Da Silva Anna Marietta
Published: May 2023

As the interest for linguistic landscape research has grown a lot in the past few decades, and so is the enthusiasm for taking advantage of linguistic landscape in language and subject-content classrooms. This paper aims at providing informative and valuable summary of works that have promoted the linguistic landscape as one of the English teaching and learning resources. Hence, it includes only papers that have specifically focused on advocating the benefits of linguistic landscape for English teaching and learning within the last ten years. The review is divided into several sections that explain the targeted participants, goal, method, advantages and several critical notes concerning the implementation of linguistic landscape projects. Suggestions for future review and studies on linguistic landscape are also provided.