bluuebunny/crossref_metadata_2025 huggingface dataset:
Neurosyphilis et évolution de la syphilis à Genève (1970–1980)
Authors: Hunziker Nicole
Published: October 2009

From 1970 to 1980 we observed 12 cases of typical neurosyphilis in Geneva. These patients had never had penicillin treatment. The incidence is about 0.3 per 100,000 inhabitants. However, it is possible that some patients with atypical neurosyphilis could have been discovered among our late serological syphilis cases if lumbar punctures and complete neurological examinations could have been carried out.
Mycosis fungoides in the Tumor Stage Treated by PUVA: A Successful Trial in a 12-Year-Old Girl
Authors: Taniguchi Shinkichi , Horio Takeshi , Komura Jinro
Published: October 2009

Mycosis fungoides in the tumor stage was seen in a 12-year-old Japanese girl. Skin lesions were cleared after 1 month of PUVA treatment and have been in remission due to the effect of maintenance therapy.
Maladie de Woringer et Kolopp
Authors: Revuz J. , Touraine R.
Published: October 2009

Woringer and Kolopp’s disease is a rare skin disease. Erythemato-squamous, slightly infiltrated lesions with round-shaped islets of normal skin are the clinical hallmarks of the disease. The histological picture is highly specific: a dense epidermal infiltrate disrupts the stratum spinosum, contrasting with a spared dermis. Three different aspects of the disease have been reported: a localized benign type as in Woringer and Kolopp’s patient; a disseminated lethal type without visceral involvement and without preexisting lesions, and a disseminated lethal type in which lesions appear on erythematous patches clinically and histologically similar to ‘parapsoriasis en plaques’. It is the opinion of the authors that the third type is not Woringer and Kolopp’s disease but an extremely epidermotropic variant of mycosis fungoides. The two other types seem to be variants of the same disease. Several hypotheses about the nature of that disorder are discussed. Most authors think that Woringer and Kolopp’s disease is a cutaneous lymphoma because of clinical, histological and ultrastructural similarities with mycosis fungoides. We are presenting evidence favoring the hypothesis of a Merkel cell proliferative disease.
Comparative Blanching Activities of Proprietary Diflucortolone Valerate Topical Preparations
Authors: Coleman G.L. , Kanfer T. , Haigh J.M.
Published: October 2009

The blanching activities and hence bioavailabilities of the cream, ointment and fatty ointment preparations of Nerisone® and Temetex® (diflucortolone valerate 0.1%) were evaluated using an occluded and unoccluded blanching assay. These products were compared to Synalar® ointment and cream (fluocinolone acetonide 0.025%), established topical corticosteroid preparations. Statistical analysis showed no significant differences between similar formulations of diflucortolone valerate. Significant differences were noted between diflucortolone valerate and fluocinolone acetonide preparations.
Hyperkeratotic Form of Porokeratosis Mibelli
Authors: Sato A. , Böhm W. , Bersch A.
Published: October 2009

A case with a hyperkeratotic form of porokeratosis Mibelli is reported. The clinical characteristics were a nonfamilial occurrence, hyperkeratotic verrucous plaques with an erythema and a segmental distribution. The histopathology showed cornoid lamellae and additional atypical findings. By electron microscopic study Civatte bodies and other degenerated epidermal cells were clarified.
Papular Dermatitis herpetiformis
Authors: Komura J. , Imamura S.
Published: October 2009

A male patient with unusual clinical features of dermatitis herpetiformis is reported. The eruption consisting mainly of erythematous papules developed symmetrically around the mouth and later around the eyes, and has been circumscribed within these areas for 4 years. The dermatitis herpetiformis nature of the lesion was confirmed by direct immunofluorescent testing.
Cell-Mediated Immunity in Epidermodysplasia verruciformis
Authors: Gliński W. , Jablonska S. , Langner A. , Obalek S. , Haftek M. , Proniewska M.
Published: October 2009

Investigations were performed in 6 cases of epidermodysplasia verruciformis and 2 healthy family members. Nonspecific cell-mediated immunity (CMI) was studied by measuring response to phytohemagglutinin (PHA) and concanavalin A (Con A), percentages of E- and EAC-rosette-forming lymphocytes, bacterial skin tests, and allergic reactions to dinitrochloro-benzene (DNCB). Impairment of CMI was manifested by reduction in the percentage of E rosettes, and lowered response to PHA, and – to a lesser degree – to Con A. The immune response to DNCB sensitization was invariably negative. Impairment of CMI was greater in cases of long duration and with extensive lesions. The cases of similar duration and extent of lesions, which never showed tendency to tumor formation, were not different in CMI in comparison with cases with numerous tumors. Only in cases with very advanced tumors CMI was impaired parallel to the gravity of the patient’s general condition.
Pyoderma gangraenosum mit Philadelphia-Chromosom-negativer chronischer myeloischer Leukämie
Authors: Kövary P.M. , Lonauer G. , Niedorf H. , Nautsch C. , Pawlowitzki I.H.
Published: October 2009

Chronic myeloid leukaemia was observed 20 months after onset of pyoderma gangraenosum in a 35-year-old female. In this case an induction by cytostatic drugs could be excluded, confirming the association of pyoderma gangraenosum with leukaemias.
Korneabefunde bei Ichthyosis
Authors: Hammerstein W. , Meiers H.G. , Haensch R.
Published: October 2009

Corneal lesions in ichthyosis, here combined with alopecia, are rarely described in the literature. The present observation relates to two sisters, whose grandparents were siblings. The mode of inheritance is autosomal recessive, as is usual in ichthyosis congenita but is also observed in ichthyosis vulgaris. The clinical picture and the histological findings correspond to ichthyosis vulgaris.
Treatment of Vitiligo with Oral Corticosteroids
Authors: Imamura S. , Tagami H.
Published: October 2009

17 patients with generalized vitiligo and 5 patients with localized vitiligo were treated with oral corticosteroids. Six patients with generalized vitiligo showed over 75% repigmentation in at least one of the patches. Two patients with generalized vitiligo and 1 patient with localized vitiligo showed a partial repigmentation of 25-75%, while 5 patients with generalized vitiligo and 1 patient with localized vitiligo showed a minimal repigmentation of less than 25%. Four patients with generalized vitiligo and 3 patients with localized vitiligo failed to respond. Repigmentation became evident within 4 weeks in most cases, and in general was more markedly noted in exposed areas.
Prognosis after Cryptogenic Cerebral Ischemia in Patients with Coagulopathies
Authors: Weber Ralph , Goertler Michael , Benemann Jens , Diener Hans Christoph , Weimar Christian
Published: October 2009

Background/Aim: Prognosis and optimal secondary prevention in ischemic stroke patients with coagulopathies remain unclear. The goal of this prospective observational multicenter study was to determine the risk of recurrence in cryptogenic stroke patients with either no or defined coagulopathies under various prevention regimens. Methods: A total of 429 patients from 14 German stroke centers with an acute cryptogenic ischemic stroke or transient ischemic attack in whom specialized coagulation testing for inherited and acquired coagulopathies (factor V Leiden mutation/resistance to activated protein C, prothrombin mutation, deficiencies of protein C, protein S, antithrombin III, anticardiolipin IgG antibodies, lupus anticoagulant) had been performed were included. Biannual follow-up in 339 (79%) of these patients assessed recurrent cerebrovascular events and secondary prevention therapy during a mean period of 2.5 years. Results: A defined coagulopathy was detected in 89 patients with follow-up, whereas no coagulopathy could be found in 250 patients with follow-up (control group). The Kaplan-Meier estimate for recurrent ischemic stroke or transient ischemic attack after 3 years was 13.6% (95% CI: 5.9–21.2%) in patients with a coagulopathy compared to 9.3% (95% CI: 5.4–13.2%) in controls, which was not significant after adjustment for potential risk factors by Cox regression analysis. Only a previous cerebrovascular ischemic event was an independent predictor for risk of recurrence in coagulopathy and control patients. Conclusions: Our observational data do not indicate a significantly increased risk for recurrent cerebrovascular events in cryptogenic stroke patients with a coagulopathy or any significant influence of the type of antithrombotic treatment.
Sweat Studies in Hyperhidrosis palmaris and plantaris
Authors: Shoenfeld Y. , Shapiro Y. , Machtiger A. , Magazanik A.
Published: October 2009

60 patients suffering from excessive sweating in the hands underwent cervical sympathectomy. At follow-up 1–7 years after operation the hands were dry in 55. No differences in electrolyte concentrations were found in the sweat from palms, arms, or body prior to and after the surgical intervention. Similarly no differences were found in electrolyte concentrations between healthy subjects and hyperhidrotics. Palmar sweat was hyper-tonic in comparison to arm or body sweat. The Na and K sweat concentrations were: palmar 50 ± 20 and 16 ± 7 mEq/1; arm 30 ± 11 and 8 ± 2 mEq/1; and body 21 ± 20 and 4 ± 3 mEq/1, respectively. Na/K ratio was: palmar 3.2; arms 3.6 and body 5.8. Total sweat loss prior to the operation was 5.7 ± 4.2 g/kg BW/h; afterwards it was 5.9 ± 4 g/kg BW/h. These equal sweat rates were associated with compensatory sweating in areas of the body not affected prior to the operation.
Mitochondrial Inclusions in Basalioma Cells
Authors: Rupec M. , Kint A.
Published: October 2009

The report is concerned with electron-opaque inclusions in the mitochondria of cells of a solid basalioma. The presence of calcium deposits is assumed.
Lichen Myxoedematosus of Urticarial Type without Paraproteinaemia
Authors: Enerbäck L. , Mobacken H.
Published: October 2009

A case is presented of lichen myxoedematosus (urticarial type) in a man aged 46, followed for 9 years without having developed extracutaneous manifestations. Some aspects of the classification of cutaneous mucinoses are discussed.
Sensitization and Testing of Guinea Pigs with Nickel Sulfate
Authors: Wahlberg Jan E.
Published: October 2009

Experiments in passive transfer of nickel allergy require highly sensitive guinea pigs and a reliable and technically usable test method. A comparison was made between two sensitization methods, the guinea pig maximization test of Magnusson and Kligman (MK) and a combined injection and painting method devised by Polak and Turk (PT). Intradermal injection was chosen as test method. The reactions to the test were greater than those of normal animals and the differences were statistically significant. With testing before the start of sensitization it was found difficult to obtain highly sensitive animals (tolerance). PT painting resulted in rather higher sensitivity with Triton X-100 than with sodium lauryl sulphate. In a comparison between the MK and PT methods, no difference in effectiveness was found provided that the animals had not been pretested. Repeated PT injections and paintings caused a further increase of the sensitivity, but the toxicity of nickel is a limiting factor.
Acid Hydrolase Activity in Normal Human Callus and in Psoriatic Scales
Authors: Roelfzema H. , van den Hurk José J.M.A. , Mier P.D.
Published: October 2009

The activities of 14 acid hydrolases have been measured in normal human callus and in psoriatic scales. Values for the scales were much higher than for callus. The increase is believed to be the result of two factors: an increased synthesis of these enzymes by the psoriatic lesion and a diminished degree of inactivation during the keratinization process.
Peutz-Jeghers Syndrome
Authors: Reddy B.S.N. , Singh Gurmohan , Chandra Sushil , Naik R.P.C. , Rao Rajanikant
Published: October 2009

Peutz-Jeghers syndrome is an uncommon genodermatosis. The clinical and radiological features of Peutz-Jeghers syndrome are described in a 12-year-old male child. The relevant literature is briefly reviewed.
Leukozytenemigration bei Syphilis späterer Stadien
Authors: Jarkovský Jindřich
Published: October 2009

Following non-specific inflammation, greater numbers of mononuclears than polymorphonuclear leukocytes were found to migrate into a ‘skin-window’ in patients with late syphilis. This mononuclear preponderance was statistically significant, the normal control subjects showing a preponderance of polymorphonuclears.
Frequence de Pityrosporum ovale dans l’oreille humaine
Authors: Randjandiche M.
Published: October 2009

Lipophilic yeasts of the genus Pityrosporum have been found in the ears of 90.3% of 124 adults and 74.3% of 74 young children.
Leishmaniose cutanée: éude ultrastructurale
Authors: Bourlond-Reinert L. , Nicolay M.
Published: October 2009

While in general agreement with previous searchers, the authors direct their attention at peculiar or unknown structures such as: a huge phagosome sometimes loaded with a paracristalline rod; an occasional set of parallel microtubules along the reservoir; eventual duplication of the blepharoplast and even of the flagellum. There appear to be some 90 microtubules in the hyaloplasm of Leishmania tropica.
Metabolism of Systematically Given Corticosteroids
Authors: Seutter E.
Published: October 2009

In the metabolism of a systemically administered corticosteroid, one of three possible main pathways is determined by the position in the molecule of the substituents which are added in the drugs to the naturally occurring ones. (I) Chiefly, hydrogenation in ring A and/or the 20-position: cortisol, cortisone, prednisolone, prednisone, and 6α-methylprednisolone. (II) In the presence of a substituent in the 16-position mainly 6β-hydroxylation: dexamethasone, betamethasone, and triamcinolone. (Ill) In the presence of a substituent in the 16-position, and fluorine in the 6α-position principally defluorination in the 6α-position and 6β-hydroxylation: fluocortolone and paramethasone. Complete metabolism, in long-term use, can be expected in the case of the ubstances mentioned under II and III, but not of those under I. Enzyme induction, both actively and passively, is negligible in group I and marked in groups II and III.
Fokale dermaIe Hypoplasie mit Keratokonus, Ösophaguspapillomen und Hidrokystomen
Authors: Zala L. , Ettlin Ch. , Krebs A.
Published: October 2009

Focal dermal hypoplasia (Goltz’s syndrome, Goltz-Gorlin syndrome), an uncommon malady belonging to the group of congenital poikiloderma, is characterized by its broad spectrum of meso-ectodermal defects involving the skin as well as the eyes, skeletal system and teeth. The case represented here is identical with the one published by Naegeli 1926, and contains some additional findings that have not yet been reported, namely: multiple hidrocystomas, bilateral keratoconus, papillomatosis of esophagus, hiatus hernia.
Subungual Squamous Cell Carcinoma
Authors: Driban Nelson E. , Lacognata Juan J.
Published: October 2009

A 58-year-old patient is described who had a tumor in the nailbed of the ring finger of his right hand. The clinical features and results of laboratory investigations are discussed.
Recherche systématique de la blennorragie dans une consultation de planning familial
Authors: Bader C. , Orusco M. , Laugier P.
Published: October 2009

We report the result of an investigation carried out in the Gynecology Policlinic of Geneva. Systematic screening of 217 patients led to the detection of 2 cases of gonorrhea. Although of interest, it is not justifiable economically to screen for gonorrhea a group of patients in whom the chances of infection are small. However, the study of a larger population might lead to a revision of this conclusion.
Initial Change of Glycosaminoglycans in Systemic Scleroderma
Authors: Ishikawa H. , Horiuchi R.
Published: October 2009

7 clinically uninvolved as well as 8 involved (6 moderately, 2 markedly) back or forearm skin specimens from 12 patients with systemic scleroderma were subjected to quantitative evaluation and to qualitative analysis of glycosaminoglycans (GAG) by one-dimensional and two-dimensional cellulose acetate electrophoresis. Skin specimens from the back, clinically uninvolved but histologically demonstrating the initial change, revealed increased amounts of hyaluronidase, chondroitinase-resistant GAG of varying electrophoretic mobilities, and one of them was chemically confirmed to be heparan sulfate variant, whereas involved skin specimens showed hardly this increase.
Generalized Mastocytosis, Relapsing Herpes Zoster and Polyradiculoneuritis
Authors: Kalz Frederick
Published: October 2009

A 68-year-old woman suffering from a longstanding urticaria pigmentosa with mast cell infiltrations in bones had two attacks of herpes zoster. The second herpes zoster attack was followed by a severe polyradiculoneuritis (Guillain-Barré syndrome). The sequence of events suggests an immunological deficiency.
Lichenoid Eruption Following Penicillamine
Authors: van de Staak W.J.B.M. , Cotton D.W.K. , Jonckheer-Venneste M.M.H. , Boerbooms A.M.T.H.
Published: October 2009

The phenomenon of lichenoid eruptions following medication with anti-malarial, anti-arthritis and antibacterial medication is well documented in the literature. We report here the first case to be described as a result of anti-arthritis treatment with penicillamine, together with some biochemical studies of the effect of this compound on the enzyme glucose-6-phosphate dehydrogenase.
Xanthomatosis and Hyperlipoproteinemia
Authors: Polano M.K.
Published: October 2009

The relation between the type of hyperlipoproteinemia and the xanthoma type found in the same patient is discussed on the basis of literature and own observations. The cholesterol level of the blood gives not enough information on disturbances in the lipoprotein metabolism, at least also triglyceride and/or total lipid estimations should be performed. Xanthomata tendinea are characteristic for an enhanced low density lipoprotein level in the blood and are often accompanied by ischemic heart disease. Eruptive xanthomata and enhanced very low density lipoprotein (VLDL) levels belong together. The enhanced VLDL level may be favorably influenced by a reduction diet with a low proportion of carbohydrates.
«Ulcera cruris» als seltene Form einer Sarkoidose
Authors: Hopf B. , Krebs A.
Published: October 2009

The erythrodermic, angiolupoid and ulcerative forms of sarcoidosis are known as rare skin manifestations of this disease. We shall report on a 63-year-old woman who, since 1950, suffered from multiple therapy-resistant ulcers of both legs. These ulcers appeared in the areas of preexisting lesions of sarcoidosis. The microscopic examination of an ulcer revealed typical epithelioid cell granulomas with thickening and hyaline sclerosis of the vessel walls and partial occlusion.
Sweet’s Syndrome
Authors: Mackie Rona M.
Published: October 2009

A case of Sweet’s syndrome (acute febrile neutrophilic dermatosis) is reported. The occurrence of systemic disorders in other reported cases is discussed. Extensive immunological studies in this case have failed to reveal any underlying abnormality.
Alcohol Consumption in Psoriasis
Authors: Grunnet E.
Published: October 2009

An investigation of drinking habits of psoriatic patients and of a control group of healthy persons is described. No difference could be detected between the alcohol consumption of these groups.
Allergic Contact Dermatitis to Virginiamycin
Authors: Baes H.
Published: October 2009

Eight cases of contact allergy to virginiamycin are reported. In all patients patch tests with fractions of both virginiamycin (factor M and S) and pristinamycin (fraction IA and IIA) were performed. All patients allergic to virginiamycin, reacted also to pristinamycin, factor M and fraction IIA. Chemically, factor M and fraction IIA appeared to be completely identical, implicating that we are dealing with false cross-sensitivity.
Réticulo-histiocytome du dos de l’adulte
Authors: Laugier P. , Hunziker N. , Olmos L.
Published: October 2009

The clinical and histopathological pattern and the ultrastructural picture of a new case of the adult’s back reticulo-histiocytome, are described. Dysplasic and malignant aspect of the infiltrated cells, confirmed by nuclear anomalies, contrasting with the slowness in evolution of the disease and a good general status, justify the individuality of this disease in the complicated family of reticuloses.
Smallpox-Induced Scars: Treatment by Dermabrasion
Authors: Vukas A.
Published: October 2009

Our own experience with the treatment of smallpox scars on the face is described. Note is taken of the fact that results are esthetically superior when treatment has been applied later after illness. The pathologic finding of epidermal adnexal organs at certain stages of the cicatrization process, which is incompatible with regenerative capabilities of the skin-forming organ, was unexpected.
Struktur und Schicksal der Desmosomen beim Morbus Darier
Authors: Vogel A. , Narasimhan S.
Published: October 2009

Atypical desmosomes are found between cells at the bottom of the lacunae in Darier’s disease. The spacing between the intermediate dense lines may be irregularly reduced, and the extracellular material can exhibit an uneven moth-eaten aspect; the intercellular contact layer is missing, but tonofibrils are connected to the attachment plaques. These desmosomes are interpreted as malformations. Desmosomes with a dilated intercellular gap are expected to split in two halves.
Tuberculoid Granulomata in Regional Lymph Nodes of Malignant Cutaneous Melanoma
Authors: de Dulanto F. , Armijo-Moreno M. , Camacho-Martínez F.
Published: October 2009

In the surgical specimen of a unilateral complete neck dissection by cervicallymph nodes in malignant cutaneous melanoma in the neck, histological examination and later complementary research made possible a diagnosis of paraneoplastic tuberculoid granulomata (‘sarcoid-like lesions’) in regional lymph nodes.
Acantholytic Keratosis
Authors: Carapeto F.J. , García-Pérez A.
Published: October 2009

The histopathological and clinical aspects of 402 cases of actinic keratosis were studied. In 18 of them (4.4%) constant histopathological pictures of acantholysis with diskeratotic cells were observed in serial sections. In none of the other 384 actinic keratosis cases were these pictures observed. Acantholytic keratosis is a variety of actinic keratosis with histopathological characteristics of its own. It should be recognized as an entity distinct from the usually reported hypertrophic, atrophic, and bowenoid forms.
Focal Dermal Hypoplasia
Authors: Zergollern Ljiljana , Laktić Nikola , Schmutzer Ljerka , Puretić Štefanija
Published: October 2009

The case of an 11-year-old girl with typical symptoms of focal dermal hypoplasia (Goltz-Gorlin syndrome) is reported. In a mentally normal child a mild body asymmetry with ocular, skin, dental, and skeletal changes, more pronounced on the right side, has been detected. A special contribution to the presentation is the dermatoglyphic finding of epidermal ridge hypoplasia on the fingertips of the right hand.
Health and Psychosocial Complaints of Elderly Ijaw Widows in Yenagoa, Nigeria
Authors: Ogungbamila Bolanle , Adeyanju Awoniyi B.
Published: October 2009

This study examined some health and psychosocial problems associated with mourning among 72 elderly Ijaw widows. The respondents complained of fever, gastrointestinal disorders and a range of psychosocial problems such as disinheritance, suspicion, frustration, hopelessness and degrading inhuman treatment. Community women/in-laws increased the extent to which elderly widows accepted traditional mourning rites. Care from nurses, good psychosocial support, health and conventional education enhanced the widows’ health status and ability to cope with mourning rites. Elderly widows in polygamous marriages experienced better psychosocial support than those in monogamous marriages. Implications for nursing and psychological practices have been highlighted in this study.
Reference Values for 27 Clinical Chemistry Tests in 70-Year-Old Males and Females
Authors: Carlsson Lena , Lind Lars , Larsson Anders
Published: October 2009

Background: Reference values are usually defined based on blood samples from healthy men or nonpregnant women in the age range of 20–50 years. These values are not optimal for elderly patients, as many biological markers change over time and adequate reference values are important for correct clinical decisions. Objective: To validate NORIP (Nordic Reference Interval Project) reference values in a 70-year-old population. Methods: We studied 27 frequently used laboratory tests. The 2.5th and 97.5th percentiles for these markers were calculated according to the recommendations of the International Federation of Clinical Chemistry on the statistical treatment of reference values. Results: Reference values are reported for plasma alanine aminotransferase, albumin, alkaline phosphatase, pancreas amylase, apolipoprotein A1, apolipoprotein B, aspartate aminotransferase, bilirubin, calcium, chloride, cholesterol, creatinine, creatine kinase, C-reactive protein, glucose, γ-glutamyltransferase, HDL-cholesterol, iron, lactate dehydrogenase, LDL-cholesterol, magnesium, phosphate, potassium, sodium, transferrin, triglycerides, urate and urea. Conclusion: Reference values calculated from the whole population and a subpopulation without cardiovascular disease showed strong concordance. Several of the reference interval limits were outside the 90% CI of a Scandinavian population (NORIP).
Allantoin in Treatment of Psoriasis
Authors: Young E.
Published: October 2009

By means of the method of paired comparisons, the value of the treatment of psoriasis by allantoin was investigated in 10 patients. In all cases allantoin failed to show any demonstrable therapeutic effect.
Paradox Temperature Response in Atopic Dermatitis
Authors: Kocsard E. , Ofner F. , Broe G.A.
Published: October 2009

It has been established in 20 patients suffering from neurodermatitis that their thermoregulation reveals abnormal reactions when determinations were made by the Pickering test. The abnormality showed itself in a drop of skin temperature – so called paradox reaction when a rise through heating was expected. This changed reaction, however, was not of a permanent nature and showed fluctuations suggestive of a functional thermo regulatory defect.
Regression de métastases de mélanome après thérapeutique immunologique
Authors: Malek-Mansour S. , Castermans-Elias S. , Lapière Ch.M.
Published: October 2009

In one patient, the appearance of superficial skin metastases of melanoma was not modified by scarification with vaccinia vaccine. Regression was observed after topical application of 2,4-dinitrochloro-benzene which resulted in complete clearing of the tegument which had persisted for over 2 years. Histological examination of some of the regressing lesions revealed infiltration by mononuclear cells and eosinophils as well as the disappearance of the neoplastic melanocytes.
Trichoepitheliom mit Strukturen eines apokrinen Adenoms
Authors: Müller-Hess S. , Delacrétaz J.
Published: October 2009

A tumor showing features of both trichoepithelioma and apocrine adenoma is reported. The combined manifestation of these two neoplasms may be explained by their common origin from the primary epithelial germ or the pkiripotentiality of the epidermal cells.
Thierschung als Verkürzung des Heilungsprozesses der Ulcera cruris
Authors: Arma-Szlachcic M. , Arma S. , Krebs A.
Published: October 2009

50 leg ulcers in 36 patients were covered by a free skin homotransplant. No signs of healing were previously attained, even after long periods of treatment. Cases of recurrent ulcers were among the ones collected.Follow-up controls revealed healing in 33 ulcers (66.6%) lasting one year after transplantation. In 17 cases however (33.3%) a recurrence had occurred. It is therefore possible to shorten considerably the period of hospitalisation necessary by performing this surgical proceeding.
Beitrag zur quantitativen Bestimmung der Hautoberflächenlipide in der Praxis
Authors: Gloor M. , Oschmann H. , Schmidt E. , Friederich H.C.
Published: October 2009

The sum of the skin surface lipids was determined by the extraction method according to Honsio, by the osmium acid test according to Brun et al. and by visual estimation. With the two latter methods it was possible to exclude with sufficient certainty a pronounced seborrhoea or sebostasis. The use of the osmium acid test did not offer any advantages over the visual judgment of skin types.
Kaposi’s Sarcoma
Authors: Feuerman E.J. , Potruch-Eisenkraft S.
Published: October 2009

The collected data of 38 patients with Kaposi’s sarcoma seen within 10 years (1960–1970) were analysed. 30 were males and 8 females, with 26 originating in East and Central Europe. In the majority, the disease had begun in the 5th and 6th decade. In most patients, only the skin was involved and the outcome was relatively good. In 4 patients, there was a general spread to skin and in 4 visceral involvement, with a lethal outcome in all 8. It is concluded that the prognosis depends on the clinical form taken by the disease and that the effect of treatment is minor. It was the authors’ impression that in cases with typical initial localisation (skin of feet and legs), there is less of a tendency for a spread to other organs, with a good prognosis, while in cases in which the disease starts elsewhere, the tendency towards spreading is more pronounced and the prognosis is more serious.
Distribution des acides nucléiques dans les cellules de l’épiderme normal
Authors: Stoian M.
Published: October 2009

The presence and distribution of the nucleic acids, DNA and RNA, in the cells of normal human epidermis were investigated with the help of different fluorochromes in fluorescent microscopy and with Feulgen type stains in electron microscopy. The results, which are in agreement, show a marked preponderance of both acids in certain cells of the basal layer and especially of DNA in their nuclei.
Hyalinosis Cutis et Mucosae
Authors: Vukas A.
Published: October 2009

A deficiency of spontaneous regeneration is characteristic for many chronic pathological skin processes. But if some vitality in their cells ist still present, we can release their inhibited embryonic properties, which then act like normal cells, reconstructing the original tissue architecture and function.
Adrenal and Pituitary Functions during Long-Term Topical Steroid Therapy
Authors: Hendrikse J.C.M. , Moolenaar A.J.
Published: October 2009

The results of investigations in 6 psoriasis patients, who have been treated with corticosteroid ointments (15–50 g daily) under occlusive dressings over a long period (minimum of 2 till more than 5 years) on the consequences of this therapy for the pituitary-adrenocortical system are related. In accordance with the literature a systemic effect during therapy is evident by a lowering of the 17-ketogenic steroids in the 24-hour urine and the plasma cortisol levels, and in an insufficient reaction to metyrapone. Stimulation with exogenous ACTH was followed by a normal adrenocortical response in all patients. With the insulin-tolerance test a good reaction to stress during therapy is found in the 5 tested patients. It is plausible, therefore, that the feedback system will resume its responsiveness after discontinuing the local therapy and that the suppression does not indicate permanent damage to the pituitary adrenal functions.
A Follow-Up Study of Treatment of Basal Cell Carcinoma with 5-Fluorouracil Ointment
Authors: Reymann F.
Published: October 2009

The results of a follow-up study comprising 88 patients having 95 basal cell carcinomas treated with 5% 5-fluorouracil ointment are reported. In order to create optimum conditions for the penetration of the antineoplastic agent, the tumor was removed by curettage, and the tumor bed was then treated with fluorouracil ointment under an occlusive dressing for six weeks. The average follow-up period is 44 months. A total of 13 recurrences were found, 12 of which occurred on an average eight months after termination of treatment. The lack of an applicable series of controls is emphasized. It is concluded that, with the technique described, there is hardly any indication for employing 5-fluorouraciI in local treatment of basal cell carcinomas of the skin.
Multiple Clear Cell Acanthomas in a Patient with Lamellar Ichthyosis
Authors: Thorne E.G. , Fusaro R.M.
Published: October 2009

Clear cell acanthoma is a benign neoplasm of keratinocytes usually occurring as a single lesion and not found with an underlying skin disorder. A patient is reported with generalized lamellar ichthyosis and scattered clear cell acanthomas. The meaning of this unique association remains obscure and is in all probability coincidental.
Reticulosis as a Long-Term Side-Effect of Methotrexate Therapy in a Patient with Generalized Psoriasis and Psoriatic Arthritis
Authors: Schröter R. , Kelleter R. , Kuhn D.
Published: October 2009

A case is presented of a patient with generalized psoriasis and psoriatic arthritis who received a low-dose Methotrexate treatment for 3 years continuously. At the end of the period he developed a lymphoreticular hyperplasia histopathologically resembling lymphosarcoma. Remission occurred after discontinuance of Methotrexate. The possibility of the immunosuppressive qualities of Methotrexate being the cause of the lymphoid reaction is discussed, and similar cases in the literature are cited. So far, long-term side-effects have played no role in Methotrexate treatment of psoriasis but they may become important when, for instance, immunosuppressive regimes are employed in the therapy of bullous dermatoses.
The Colour of Human Skin
Authors: Wassermann H.P.
Published: October 2009

(1) From spectral reflectance curves of 631 individuals of three ethnic groups (colour-coded as white, brown and black) the lightest, darkest and several intermediate individuals were selected for reflectance studies with X, Y and Z filters to plot a colour definition in terms of hue, saturation and luminosity from the CIE chromaticity chart. (2) These values were presented as a three dimensional model. (3) From this study the hue of all skins were red, and the differences were due to differences in luminosity. Brown skin was the most saturated red, and saturation decreased towards white and black. (4) The conceptual significance of colour specification is considered in relation to the epidermal melanin unit and the phenomenon of dichroism.
Über die Toxizität der Borsäure
Authors: Schuppli R. , Seiler H. , Schneeberger R. , Niggli H. , Hoffmann K.
Published: October 2009

The boric acid concentration in the blood of 21 hospitalised patients, having been treated with wet compresses of boric acid over several days, has been determined. Only in 1 patient a significant rise of the boric concentration was found, probably due to a preexisting kidney damage. On the basis of the assumption that a therapy with boric acid may be dangerous to patients with kidney diseases, laboratory experiments have been carried out with rabbits whose kidneys had been artificially damaged prior to the boric acid application. It could be demonstrated that the half value time of boric acid in the blood was significantly prolonged. In using boric acid, therefore, special care must be taken with regard to existing kidney damages, as the toxic limit in the blood may easily be reached through cumulation.
Untersuchungen über Gruppensensibilisierung gegen neue Hydroxychinolin-Derivate
Authors: Fiedler H. , Novák M. , Schwank R.
Published: October 2009

Patch tests with 15 different 8-hydroxyquinolines and with quinoline were performed on 9 patients primarily sensitized to 5,7-dichloro-8-hydroxyquinoline. Besides sensitivity to 5,7-dichloro-8-hydroxyquinoline there was a strong effect against 7-chloro-8-hydroxyquinoline, less against 5-chloro-8-hydroxyquinoline and the mildest sensitization activity to 8-hydroxyquinoline. Regarding the methyl-8-hydroxyquinolines only the 7-methyl compound gave positive reactions whereas 5- and 2-methyl-8-hydroxyquinoline were without effect. The sensitizing ability was abolished by blocking of the 8-hydroxyl group or by oxidation of the N-atom of quinoline to N-oxide.
Alternate-Day Corticosteroid Regimen
Authors: Haim S. , Benderly A. , Shafrir A. , Levy J.
Published: October 2009

Alternate-day prednisone therapy was tried in 21 children, with rheumatic fever, 1 with nephrotic syndrome, and in 14 patients with pemphigus vulgaris. Ten of the latter were already treated by the conventional daily method and their lesions were well controlled by a carefully established daily maintenance dose. The additional 4 received the alternate-day treatment directly after their lesions were first controlled by the daily method. The follow-up of our cases revealed the following: (a) the adverse reactions to this regimen were comparatively mild and rare, and most of the already existing ones improved or disappeared totally, (b) the endogenous pituitary adrenal function was well preserved and in 3 it returned to normal following its depression by the daily method, (c) the treatment was apparently as effective as the daily devided doses regimen, (d) in 1 patient with pemphigus vulgaris the treatment failed to bring a primary remission, however, it was effective in maintaining the remission achieved by the daily method.
Aspects ultrastructuraux des dermatophytes
Authors: Stoian M.
Published: October 2009

Besides the usual ultrastructural patterns reported up to now in pathogenic fungi, the author points out some other subcellular aspects still unknown. The endoplasmic reticulum and ribosomes are definitely present contrary to previous reports. Very osmiophobe and granular deposits are frequently observed in the vicinity of, or often, even in direct contact with the chitinous fungal wall. It seems that intimate dependences exist between the fungal wall and these granular deposits. It could be that the latter are involved in the construction and development of the chitinous wall. Furthermore very fine canalicular Golgi-like structures are also present in the immediate neighbourhood of the granular deposits. It is very likely that the granular material originates from this Golgi-like structures. The dense bodies and their passage through the septal porum are also discussed.
The Discovery of Cellular Immunity in the Atherosclerotic Plaque
Authors: Hansson Göran K. , Jonasson Lena
Published: October 2009

It is now generally accepted that atherosclerosis is an inflammatory/immune disease triggered by LDL accumulation in the artery wall. When discovering T cells and the molecular components of a cellular immune response, we proposed that atherosclerosis is an inflammatory process with an autoimmune component. This notion was met with general skepticism but has gained support from experimental and clinical studies. Here we describe some of the early studies that helped developing this concept.
Kernel Methods for Minimally Supervised WSD
Authors: Giuliano Claudio , Gliozzo Alfio Massimiliano , Strapparava Carlo
Published: October 2009

We present a semi-supervised technique for word sense disambiguation that exploits external knowledge acquired in an unsupervised manner. In particular, we use a combination of basic kernel functions to independently estimate syntagmatic and domain similarity, building a set of word-expert classifiers that share a common domain model acquired from a large corpus of unlabeled data. The results show that the proposed approach achieves state-of-the-art performance on a wide range of lexical sample tasks and on the English all-words task of Senseval-3, although it uses a considerably smaller number of training examples than other methods.
Biogeography and variations in allopatric populations of Distolabrellus veechi Anderson, 1983 (Nematoda: Rhabditidae)
Authors: Tahseen Qudsia , Shah Ali Asghar , Khan Rahmat , Sultana Razia , Hussain Ather , Ahmad Irfan
Published: October 2009

A detailed description of Distolabrellus veechi (syn. nov. D. pakistanensis)
is given based on variations observed in different populations collected
from India and Korea, and comparisons made with those reported from Arizona
and Argentina. The populations, which showed a great degree of morphometric
overlap and a continuous range in variation, could not be differentiated
from the type population of D. veechi. The relationships of the populations
were studied using morphological data subjected to cluster analysis. The
characteristics of the species and its relationship with Teratorhabditis are
also discussed. Biogeographical information revealed an interesting trend of
distribution for the species, i.e., between 22-55° north and south of the
equator.
Budget Consolidation Options for the UK
Authors: Barrell Ray
Published: October 2009

The increase in UK public sector net borrowing in the past year, plotted in figure 1, has been in part a result of the decline in economic activity, and also a consequence of the change in housing and financial market transactions. The former is predictable with every 1 per cent decline in output below trend producing a decline in net revenues of of between one third and three fifths of a per cent of GDP depending upon the reason for the decline in output. The loss from the decline in asset-related revenues is harder to judge, but the April 2009 budget suggested that revenue losses might be more than 1 per cent of GDP.
Citizen Support for Military Expenditures: A Longitudinal Analysis of U.S. Public Opinion, 1999—2002
Authors: Simon Christopher A. , Lovrich Nicholas P.
Published: October 2009

Previous research on public opinion regarding military expenditures in the United States was conducted predominantly in the cold war context. This analysis of public opinion in thirty major U.S. cities over the period 1999 through 2002 revisits this earlier literature in light of changing sociopolitical conditions during a period bracketing the onset of the war on terrorism. The study offers support for much of the earlier research with respect to sources of support for robust military expenditures, in the process illustrating the value of archival data in replicating key research findings in extant literature conducted in a cold war context. The results of the multivariate analysis offer important insights into the sources of public support for military expenditure in the post-9/11 setting.
Changing Minority Representation in the U.S. Military
Authors: Armor David J. , Gilroy Curtis L.
Published: October 2009

The Department of Defense has always sought a socially representative enlisted force, especially with respect to African American and Hispanic minorities. Ideally, in a democratic society a military force should be representative of the nation it defends. African American overrepresentation was a major concern during the first decade of the All-Volunteer Force (AVF), while Hispanics were underrepresented. During the 1980s black representation stabilized and Hispanics began to increase, especially with respect to enlistments. Starting in the 1990s, black representation began to decline, followed more recently by declines among Hispanics. This article examines changes in minority representation since the inception of the AVF in 1973 and argues that the wars in Afghanistan and Iraq have played a significant role in recent changes.
The Role of Trust in Secure and Insecure Employment Situations: A Multiple-Group Analysis
Authors: de Jong Jeroen , Schalk René , Croon Marcel
Published: October 2009

This article assesses the impact of job insecurity on the mediating role of trust in the relationship between breach of the psychological contract and employee attitudes. It is argued that both objective and subjective job insecurity influence the relation between breach and trust, as well as the relation between breach and affective commitment, job satisfaction and intention to quit. Hypotheses for different configurations of subjective and objective job insecurity were tested in a sample of 834 Dutch workers employed in 48 organizations. In a multiple-group analysis, the relationships between breach, trust and employee attitudes in four groups of employees in different configurations of job security were analysed. The results show that objective job insecurity moderates the relationship between breach and trust. However, contrary to expectations, trust only partially mediates between breach and employee attitudes in all employment situations.
The Impact of Cross-Border Mergers on the Co-Decision-Making Process: The Case of a Danish Company
Authors: Rocha Robson Sø
Published: October 2009

The present article investigates changes over time in the patterns of co-decision-making in a Danish multinational company that has grown through cross-border mergers and acquisitions. The findings show the difficulties that trade union representatives and management face when firms try to introduce a governance regime based on shareholder value ideology. The Danish tradition of cooperation between management and labour was especially affected, since the changes in co-decision-making processes destroyed more than top management understood or realized. The article argues that hybrid forms of governance are unlikely to emerge due to historically embedded governance institutions, which create distinct expectations about how a firm must be governed and who has the right to participate in this governance. The spread of the Anglo-Saxon model of governance in Europe is likely to have negative effects on co-decision-making processes and established patterns of organizational cooperation.
Single Mothers, Single Fathers: Gender Differences in Fertility After a Nonmarital Birth
Authors: Guzzo Karen Benjamin , Hayford Sarah R.
Published: October 2009

Research on nonmarital fertility has focused almost exclusively on unmarried mothers, due in part to a lack of fertility information for men. Cycle 6 of the National Survey of Family Growth allows exploration of nonmarital fertility for both genders.The authors compare the characteristics of unmarried first-time mothers ( n = 2,455) and fathers ( n = 797), use event history techniques to model second-birth hazards, and examine the distribution of men’s and women’s second births across types of relationships. The authors’ analysis is motivated by questions about how selection into nonmarital fertility relates to subsequent fertility behavior and by theories of mate selection and the “relationship” market. The authors found that unmarried mothers are more likely to have a second birth than unmarried fathers, driven largely by a higher hazard of having a noncoresidential second birth.