bluuebunny/crossref_metadata_2025 huggingface dataset:
Test Anxiety in Autistic University Students—Preliminary Results from a German-Speaking Sample
Authors: Zavery Alafia , Zäch Myriam , Bertrams Alex
Published: March 2021

Autism is a neurodevelopmental condition associated with increased levels of anxiety. However, whether autism is related to heightened test anxiety as one situation-specific type of anxiety has not yet been examined. This question may be relevant for the achievement and well-being of autistic people in educational settings (e.g., at universities). In this study, we took a first step to investigate whether autistic university students have increased test anxiety. A sample of 16 German-speaking university students completed an established diagnostic instrument to measure test anxiety and its components of worry, emotionality, cognitive interference, and lack of confidence. The scores of the autistic students were compared with the test anxiety means and percentile ranks of the standardization sample for the applied test anxiety measure (n = 1350). For an additional comparison, the test anxiety means and percentile ranks of non-autistic university students (n = 101) were assessed during the last third of the semester; that is, close to the examinations. Overall, the results suggest that autistic university students have remarkably increased test anxiety. Although the present findings must be considered preliminary, they suggest that text anxiety in educational settings may be a neglected significant problem for autistic people that requires further attention in research and practice.
Factors That Affect the Level of Success of the Transaction between Home Buyers and Developers in Sell-Build Residential Projects
Authors: Aslan Selman , Arditi David , Tantekin-Çelik Gözde
Published: March 2021

The “Sell-Build” model in residential project transactions involves a home buyer agreeing to pay the developer in monthly installments starting very early in the design or construction phases of a project. It is hypothesized that the success of this transaction depends on (1) the home buyer’s knowledge about the transaction process and (2) the mutual trust between home buyer and developer. A survey was administered to 250 home buyers and 70 developers in Turkey to collect demographic information about the participants and about the participants’ perceptions of not only the success of the transactions they were involved in, but also of the impacts of how informed home buyers are about the transaction process and how much the two parties trust each other. The data collected was subjected to statistical analysis. The findings indicate that (1) the home buyer should make a special effort to study relevant materials and consult specialists before entering into an agreement with a developer, and (2) the trust between home buyer and developer depends largely on the buyer’s uninterrupted flow of monthly installment payments starting early in the project. The contribution of this study is that it provides a useful guideline to home buyers and developers.
Alternative Non-Homologous End-Joining: Error-Prone DNA Repair as Cancer’s Achilles’ Heel
Authors: Caracciolo Daniele , Riillo Caterina , Di Martino Maria Teresa , Tagliaferri Pierosandro , Tassone Pierfrancesco
Published: March 2021

Error-prone DNA repair pathways promote genomic instability which leads to the onset of cancer hallmarks by progressive genetic aberrations in tumor cells. The molecular mechanisms which foster this process remain mostly undefined, and breakthrough advancements are eagerly awaited. In this context, the alternative non-homologous end joining (Alt-NHEJ) pathway is considered a leading actor. Indeed, there is experimental evidence that up-regulation of major Alt-NHEJ components, such as LIG3, PolQ, and PARP1, occurs in different tumors, where they are often associated with disease progression and drug resistance. Moreover, the Alt-NHEJ addiction of cancer cells provides a promising target to be exploited by synthetic lethality approaches for the use of DNA damage response (DDR) inhibitors and even as a sensitizer to checkpoint-inhibitors immunotherapy by increasing the mutational load. In this review, we discuss recent findings highlighting the role of Alt-NHEJ as a promoter of genomic instability and, therefore, as new cancer’s Achilles’ heel to be therapeutically exploited in precision oncology.
A MAPK/miR-29 Axis Suppresses Melanoma by Targeting MAFG and MYBL2
Authors: Vera Olga , Bok Ilah , Jasani Neel , Nakamura Koji , Xu Xiaonan , Mecozzi Nicol , Angarita Ariana , Wang Kaizhen , Tsai Kenneth Y. , Karreth Florian A.
Published: March 2021

The miR-29 family of microRNAs is encoded by two clusters, miR-29b1~a and miR-29b2~c, and is regulated by several oncogenic and tumor suppressive stimuli. While in vitro evidence suggests a tumor suppressor role for miR-29 in melanoma, the mechanisms underlying its deregulation and contribution to melanomagenesis have remained elusive. Using various in vitro systems, we show that oncogenic MAPK signaling paradoxically stimulates transcription of pri-miR-29b1~a and pri-miR-29b2~c, the latter in a p53-dependent manner. Expression analyses in melanocytes, melanoma cells, nevi, and primary melanoma revealed that pri-miR-29b2~c levels decrease during melanoma progression. Inactivation of miR-29 in vivo with a miRNA sponge in a rapid melanoma mouse model resulted in accelerated tumor development and decreased overall survival, verifying tumor suppressive potential of miR-29 in melanoma. Through integrated RNA sequencing, target prediction, and functional assays, we identified the transcription factors MAFG and MYBL2 as bona fide miR-29 targets in melanoma. Our findings suggest that attenuation of miR-29b2~c expression promotes melanoma development, at least in part, by derepressing MAFG and MYBL2.
Physico-Chemical Changes in the KCl-MgCl2/La-FAU Composite Catalyst Induced by Oxidative Dehydrogenation of Ethane
Authors: Sajad Mehran , Bulánek Roman , Šlang Stanislav
Published: March 2021

In this research, a binary eutectic composition of KCl and MgCl2 supported over lanthanum exchanged FAU (faujasite) zeolite has been investigated for the oxidative dehydrogenation (ODH) of ethane. The catalyst was prepared by the thermal treatment of La-FAU with a mechanical mixture of alkali chlorides under a flow of helium at 500 °C. The eutectic mixture of alkali chlorides formed at this temperature and a molten layer were spread over the support. Synthesized fresh and spent catalysts were characterized to obtain information about changes in crystallinity, textural properties, phase content, chemical composition, and morphology of the catalyst over the reaction time. The initial conversion of ethane was 80% with ethene as the main product (65% yield). The catalyst deactivation has been demonstrated over time on the stream (TOS). The characterization methods confirmed that the chlorine was being removed from the catalyst. The side products detected by mass spectroscopy, including chlorinated hydrocarbons, have been found as a key pathway of chlorine removal from the catalyst. The exchange of chlorine for oxygen in the catalyst led to a significant decrease in the activity and production of higher hydrocarbons and their oxygenates as side products of the ODH reaction.
Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight
Authors: Hopp Ann-Katrin , Hottiger Michael O.
Published: March 2021

Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids. While ARTD1/PARP1-mediated poly-ADP-ribosylation has extensively been studied in the past 60 years, comparably little is known about the physiological function of mono-ADP-ribosylation and the enzymes involved in its turnover. Promising technological advances have enabled the development of innovative tools to detect NAD+ and NAD+/NADH (H for hydrogen) ratios as well as ADP-ribosylation. These tools have significantly enhanced our current understanding of how intracellular NAD dynamics contribute to the regulation of ADP-ribosylation as well as to how mono-ADP-ribosylation integrates into various cellular processes. Here, we discuss the recent technological advances, as well as associated new biological findings and concepts.
Heat Shock Protein 27 Is an Emerging Predictor of Contrast-Induced Acute Kidney Injury on Patients Subjected to Percutaneous Coronary Interventions
Authors: Jaroszyński Andrzej , Zaborowski Tomasz , Głuszek Stanisław , Zapolski Tomasz , Sadowski Marcin , Załuska Wojciech , Cedro Anna , Małecka-Massalska Teresa , Dąbrowski Wojciech
Published: March 2021

Contrast-induced acute kidney injury (CI-AKI) is a serious complication associated with considerable morbidity and mortality. Heat-shock protein 27 (HSP27) plays a role in the defense of the kidney tissue against various forms of cellular stress, including hypoxia and oxydative stress, both features associated with CI-AKI. The aim of our study was to evaluate a potential predictive value of HSP27 for CI-AKI in patients subjected to percutaneous coronary interventions (PCI). Included were 343 selected patients subjected to PCI. Exclusion criteria were conditions that potentially might influence HSP27 levels. HSP27 serum levels were evaluated prior to PCI, together with serum creatinine, the concentration of which was also evaluated twice at 48 and 72 h post PCI. CI-AKI was diagnosed in 9.3% of patients. Patients in whom CI-AKI was diagnosed were older (p < 0.001), were more often females (p = 0.021), had higher prevalence of diabetes (p = 0.011), hypotension during PCI (p < 0.001), albuminuria (p = 0.004) as well as multivessel disease (p = 0.002), received higher contrast volume (p = 0.006), more often received contrast volume (CV) above the maximum allowed contrast dose (MACD) (p < 0.001), and had lower HSP27 level (p < 0.001). On multivariate analysis, CV > MACD (OR 1.23, p = 0.001), number of diseased vessels (OR 1.27, p = 0.006), and HSP27 (OR 0.81, p = 0.001) remained independent predictors of CI-AKI. Low concentration of HSP27 is an emerging, strong and independent predictor of CI-AKI in patients subjected to PCI.
A Household-Based Survey of Iodine Nutrition in Moroccan Children Shows Iodine Sufficiency at the National Level But Risk of Deficient Intakes in Mountainous Areas
Authors: El Ammari Laila , Saeid Naima , Talouizte Anouar , Gamih Hasnae , Labzizi Salwa , Mendili Jamila El , Rami Anass , Idrissi Mohamed , Benjeddou Kaoutar , Zahrou Fatima ezzahra , Elmzibri Mohamed , Brown Amal Tucker , Al-Jawaldeh Ayoub , Yahyane Abdelhakim , Zimmerman Michael Bruce , Kari Khalid El , Aguenaou Hassan
Published: March 2021

Historically, mountainous areas of Morocco have been affected by endemic goiter and severe iodine deficiency. In 1995, Morocco legislated salt iodization to reduce iodine deficiency. There has been no national survey of iodine nutrition in school-age children for nearly 3 decades. Our aim was to assess iodine nutrition in a national sample of 6–12-year-old children in Morocco to inform the national salt iodization strategy. In this cross-sectional household-based survey, we randomly recruited healthy 6–12-year-old children from 180 clusters in four geographic zones (north and east, central, north and south) covering the 12 regions of Morocco. A questionnaire was completed, including socio-economic status and parental level of education. In addition, anthropometric measurements were taken to assess nutrition status, and a spot urine sample was collected to measure urinary iodine concentration (UIC). A total of 3118 households were surveyed, and 1043 eligible children were recruited, 56% from urban areas and 44% from rural areas. At the national level, the percentage of surveyed samples with UIC < 50 μg/L was 21.6% (19.2%; 24.2%), which exceeds the WHO suggestion of no more than 20% of samples below 50 μg/L, despite an adequate level of median urinary iodine concentration (mUIC) at 117.4 µg/L (110.2; 123.3). There were no statistically significant differences in mUIC comparing urban vs. rural areas and socio-economic status. However, the mUIC was significantly lower in the central (high-altitude non-coastal) zone (p < 0.004), where the mUIC (95% CI) was deficient at 89.2 µg/L (80.8; 102.9). There was also a significant difference in the mUIC by head of household education level (p = 0.008). The mUIC in Moroccan children >100 µg/L indicates iodine sufficiency at the national level. However, the percentage of surveyed samples with UIC < 50 μg/L above suggests that a significant proportion of children remain at risk for iodine deficiency, and it appears those at greatest risk are residing in the central (high altitude non-coastal) zone. A national level mUIC value may conceal discrepancies in iodine intake among different sub-groups, including those defined by geographic region.
Development of Antibacterial, Antioxidant, and UV-Barrier Chitosan Film Incorporated with Piper betle Linn Oil as Active Biodegradable Packaging Material
Authors: Nguyen Thuong Thi , Nguyen Thu-Thao Thi , Tran Thuan Van , Tan Lam Van , Danh Luu Thai , Than Van Thai
Published: March 2021

This study aims to introduce the antibacterial and antioxidant activities of the Piper betle Linn oil (PBLO) into chitosan film (pCS), named as pCS-PBLO film. The morphology, structure, and properties of the pCS-PBLO film, along with the PBLO concentration between 0.4% and 1.2% (v/v), were determined. The film surface became rough and heterogeneous with the addition of PBLO, which directly influenced on mechanical strength of the resultant film. The addition of the PBLO did not affect thermal stability but significant effect on flexibility and mobility of the film. Importantly, the film enhanced the UV-protective property and antioxidant activity as incorporated-PBLO. Moreover, the resulting film revealed the great inhibition efficiency against the negative-gram (E. coli, P. aeruginosa, and S. typhi) and positive-gram (S. aureus) bacteria based on phenolic compounds, such as the acetyleugenol, eugenol, 4-allyl-1,2-diacetoxybenzen, and chavicol acetate in PBLO components. In particular, the pCS-PBLO film may extend the shelf life of king oranges up to two weeks at 25 °C that is longer as compared to the uncoated sample and coated with chitosan alone. These results suggest that the pCS-PBLO film can be used as environmental-friendly and effective food packaging material in the future.
Effects of Joule Heating and Viscous Dissipation on Magnetohydrodynamic Boundary Layer Flow of Jeffrey Nanofluid over a Vertically Stretching Cylinder
Authors: Ur Rasheed Haroon , AL-Zubaidi Abdou , Islam Saeed , Saleem Salman , Khan Zeeshan , Khan Waris
Published: March 2021

This article investigates unsteady magnetohydrodynamic (MHD) mixed convective and thermally radiative Jeffrey nanofluid flow in view of a vertical stretchable cylinder with radiation absorption and heat; the reservoir was addressed. The mathematical formulation of Jeffrey nanofluid is established based on the theory of boundary layer approximations pioneered by Prandtl. The governing model expressions in partial differential equations (PDEs) form was transformed into dimensionless form via similarity transformation technique. The set of nonlinear nondimensional partial differential equations are solved with the help of the homotopic analysis method. For the purpose of accuracy, the optimizing system parameters, convergence, and stability analysis of the analytical algorithm (CSA) were performed graphically. The velocity, temperature, and concentration flow are studied and shown graphically with the effect of system parameters such as Grashof number, Hartman number, Prandtl number, thermal radiation, Schmidt number, Eckert number, Deborah number, Brownian parameter, heat source parameter, thermophoresis parameter, and stretching parameter. Moreover, the consequence of system parameters on skin friction coefficient, Nusselt number, and Sherwood number is also examined graphically and discussed.
Optical Biomarkers for the Diagnosis of Osteoarthritis through Raman Spectroscopy: Radiological and Biochemical Validation Using Ex Vivo Human Cartilage Samples
Authors: Casal-Beiroa Paula , Balboa-Barreiro Vanesa , Oreiro Natividad , Pértega-Díaz Sonia , Blanco Francisco J. , Magalhães Joana
Published: March 2021

Osteoarthritis (OA) is the most common rheumatic disease, characterized by progressive articular cartilage degradation. Raman spectroscopy (RS) has been recently proposed as a label-free tool to detect molecular changes in musculoskeletal tissues. We used cartilage samples derived from human femoral heads to perform an ex vivo study of different Raman signals and ratios, related to major and minor molecular components of articular cartilage, hereby proposed as candidate optical biomarkers for OA. Validation was performed against the radiological Kellgren–Lawrence (K-L) grading system, as a gold standard, and cross-validated against sulfated glycosaminoglycans (sGAGs) and total collagens (Hyp) biochemical contents. Our results showed a significant decrease in sGAGs (SGAGs, A1063 cm−1/A1004 cm−1) and proteoglycans (PGs, A1375 cm−1/A1004 cm−1) and a significant increase in collagen disorganization (ColD/F, A1245 cm−1/A1270 cm−1), with OA severity. These were correlated with sGAGs or Hyp contents, respectively. Moreover, the SGAGs/HA ratio (A1063 cm−1/A960 cm−1), representing a functional matrix, rich in proteoglycans, to a mineralized matrix-hydroxyapatite (HA), was significantly lower in OA cartilage (K-L I vs. III–IV, p < 0.05), whilst the mineralized to collagenous matrix ratio (HA/Col, A960 cm−1/A920 cm−1) increased, being correlated with K-L. OA samples showed signs of tissue mineralization, supported by the presence of calcium crystals-related signals, such as phosphate, carbonate, and calcium pyrophosphate dihydrate (MGP, A960 cm−1/A1004 cm−1, MGC, A1070 cm−1/A1004 cm−1 and A1050 cm−1/A1004 cm−1). Finally, we observed an increase in lipids ratio (IL, A1450 cm−1/A1670 cm−1) with OA severity. As a conclusion, we have described the molecular fingerprint of hip cartilage, validating a panel of optical biomarkers and the potential of RS as a complementary diagnostic tool for OA.
Tumour Versus Germline BRCA Testing in Ovarian Cancer: A Single-Site Institution Experience in the United Kingdom
Authors: Akaev Iolia , Rahimi Siavash , Onifade Olubukola , Gardner Francis John Edward , Castells-Rufas David , Jones Eleanor , Acharige Shyamika , Yeoh Chit Cheng
Published: March 2021

The aim of this audit was to evaluate the usefulness and serviceability of testing for pathogenic mutations in BRCA1 or BRCA2 (BRCA1/2) genes in ovarian cancer (OC) patients. One hundred and thirty-five patients with more common histological sub-types of OC were retrospectively identified between 2011 and 2019. The fail rate of the molecular analysis was 7.4% (10/135). One hundred and twenty-five records were evaluated: 99 (79.2%) patients had wild-type BRCA (both somatic and germline); tumour BRCA1/2 (tBRCA1/2) pathogenic mutations were found in 20 (16%) patients with distribution between BRCA1 and BRCA2 being 40% and 60%, respectively; 13 (10.4%) patients with pathogenic variants had germline mutations; and tBRCA1/2 with variant of unknown significance (VUS), in the absence of pathogenic BRCA1 or BRCA2 variants, was detected in 6 (4.8%) patients. Our data show that expanding the molecular service to the routine first-tumour testing for patients with OC will potentially increase the detection rate of BRCA mutations, thereby providing early benefits of PARP inhibitors therapy. The tumour testing service should continue to be offered to newly diagnosed patients with high-grade epithelial cancers, including high-grade serous carcinoma, but also with carcinosarcomas and poorly-differentiated metastatic adenocarcinomas of unknown origin.
Forgotten No More—The Role of Right Ventricular Dysfunction in Heart Failure with Reduced Ejection Fraction: An Echocardiographic Perspective
Authors: Vijiiac Aura , Onciul Sebastian , Guzu Claudia , Scarlatescu Alina , Petre Ioana , Zamfir Diana , Onut Roxana , Deaconu Silvia , Dorobantu Maria
Published: March 2021

During the last decade, studies have raised awareness of the crucial role that the right ventricle plays in various clinical settings, including diseases primarily linked to the left ventricle. The assessment of right ventricular performance with conventional echocardiography is challenging. Novel echocardiographic techniques improve the functional assessment of the right ventricle and they show good correlation with the gold standard represented by cardiac magnetic resonance. This review summarizes the traditional and innovative echocardiographic techniques used in the functional assessment of the right ventricle, focusing on the role of right ventricular dysfunction in heart failure with reduced ejection fraction and providing a perspective on recent evidence from literature.
Role of Fusion Imaging in Image-Guided Thermal Ablations
Authors: Carriero Serena , Della Pepa Gianmarco , Monfardini Lorenzo , Vitale Renato , Rossi Duccio , Masperi Andrea , Mauri Giovanni
Published: March 2021

Thermal ablation (TA) procedures are effective treatments for several kinds of cancers. In the recent years, several medical imaging advancements have improved the use of image-guided TA. Imaging technique plays a pivotal role in improving the ablation success, maximizing pre-procedure planning efficacy, intraprocedural targeting, post-procedure monitoring and assessing the achieved result. Fusion imaging (FI) techniques allow for information integration of different imaging modalities, improving all the ablation procedure steps. FI concedes exploitation of all imaging modalities’ strengths concurrently, eliminating or minimizing every single modality’s weaknesses. Our work aims to give an overview of FI, explain and analyze FI technical aspects and its clinical applications in ablation therapy and interventional oncology.
Telegraphic Transport Processes and Their Fractional Generalization: A Review and Some Extensions
Authors: Masoliver Jaume
Published: March 2021

We address the problem of telegraphic transport in several dimensions. We review the derivation of two and three dimensional telegrapher’s equations—as well as their fractional generalizations—from microscopic random walk models for transport (normal and anomalous). We also present new results on solutions of the higher dimensional fractional equations.
Gain Expressions for Capacitive Wireless Power Transfer with One Electric Field Repeater
Authors: Minnaert Ben , Monti Giuseppina , Costanzo Alessandra , Mongiardo Mauro
Published: March 2021

In this paper, the use of a repeater element between the transmitter and the receiver of a capacitive wireless power transfer system for achieving larger transfer distances is analyzed. A network formalism is adopted and the performance described by using the three power gains usually adopted in the context of two-port active networks. The analytical expressions of the gains as function of the network elements are derived. Assuming that the parameters of the link are given and fixed, including the coupling factors between transmitter, repeater and receiver, the conditions for maximizing the different gains by acting on the network terminating impedances (i.e., load and internal source conductance) are determined. The analytical formulas are verified through circuital simulations.
Futuristic Trends and Innovations for Examining the Performance of Course Learning Outcomes Using the Rasch Analytical Model
Authors: Nasralla Moustafa M. , Al-Shattarat Basiem , Almakhles Dhafer J. , Abdelhadi Abdelhakim , Abowardah Eman S.
Published: March 2021

The literature on engineering education research highlights the relevance of evaluating course learning outcomes (CLOs). However, generic and reliable mechanisms for evaluating CLOs remain challenges. The purpose of this project was to accurately assess the efficacy of the learning and teaching techniques through analysing the CLOs’ performance by using an advanced analytical model (i.e., the Rasch model) in the context of engineering and business education. This model produced an association pattern between the students and the overall achieved CLO performance. The sample in this project comprised students who are enrolled in some nominated engineering and business courses over one academic year at Prince Sultan University, Saudi Arabia. This sample considered several types of assessment, such as direct assessments (e.g., quizzes, assignments, projects, and examination) and indirect assessments (e.g., surveys). The current research illustrates that the Rasch model for measurement can categorise grades according to course expectations and standards in a more accurate manner, thus differentiating students by their extent of educational knowledge. The results from this project will guide the educator to track and monitor the CLOs’ performance, which is identified in every course to estimate the students’ knowledge, skills, and competence levels, which will be collected from the predefined sample by the end of each semester. The Rasch measurement model’s proposed approach can adequately assess the learning outcomes.
Study and Assessment of Defect and Trap Effects on the Current Capabilities of a 4H-SiC-Based Power MOSFET
Authors: Pezzimenti Fortunato , Bencherif Hichem , De Martino Giuseppe , Dehimi Lakhdar , Carotenuto Riccardo , Merenda Massimo , Della Corte Francesco G.
Published: March 2021

A numerical simulation study accounting for trap and defect effects on the current-voltage characteristics of a 4H-SiC-based power metal-oxide-semiconductor field effect transistor (MOSFET) is performed in a wide range of temperatures and bias conditions. In particular, the most penalizing native defects in the starting substrate (i.e., EH6/7 and Z1/2) as well as the fixed oxide trap concentration and the density of states (DoS) at the 4H-SiC/SiO2 interface are carefully taken into account. The temperature-dependent physics of the interface traps are considered in detail. Scattering phenomena related to the joint contribution of defects and traps shift the MOSFET threshold voltage, reduce the channel mobility, and penalize the device current capabilities. However, while the MOSFET on-state resistance (RON) tends to increase with scattering centers, the sensitivity of the drain current to the temperature decreases especially when the device is operating at a high gate voltage (VGS). Assuming the temperature ranges from 300 K to 573 K, RON is about 2.5 MΩ·µm2 for VGS > 16 V with a percentage variation ΔRON lower than 20%. The device is rated to perform a blocking voltage of 650 V.
Robust Control of a PMSG-Based Wind Turbine Generator Using Lyapunov Function
Authors: Pourebrahim Roghayyeh , Shotorbani Amin Mohammadpour , Márquez Fausto Pedro García , Tohidi Sajjad , Mohammadi-Ivatloo Behnam
Published: March 2021

This paper proposes a robust finite-time controller (FTC) for a permanent magnet synchronous generator (PMSG)-based wind turbine generator (WTG). An adaptive observer is used for the rotor angle, rotor speed, and turbine torque estimations of the PMSG, thus eliminating the use of anemometers. The robustness of the proposed FTC regarding parameter uncertainty and the external weak power grid is analyzed. The impacts of the power grid short-circuit ratio (SCR) at the point of common coupling (PCC) on the conventional proportional-integral (PI) controller and the proposed FTC are discussed. Case studies illustrate that the proposed observer-based FTC is able to estimate the mechanical variables accurately and provides robust control for WTGs with parameter uncertainty and weak power grids.
Parasitic Effects of PWM-VSI Control Leading to Torque Harmonics in AC Drives
Authors: Plotkin Juriy , Almuratova Nurgul , Yerzhan Assel , Petrushin Victor
Published: March 2021

Precise torque control without pulsations is one of the major quality issues in pulse-width modulated voltage-source inverter (PWM-VSI) drives. Theoretically, it could be postulated that at frequencies of some kHz, the machine’s inertia absorbs switching frequency torque harmonics, and the resulting torque becomes smooth; though, in reality, parasitic effects in voltage source inverters may cause additional torque harmonics of low order. In particular, first, second and sixth torque harmonics are observed. Such torque harmonics are especially dangerous for normal drive operation, since they may be amplified by drive train resonances at corresponding rotational velocities. New parasitic effects in PWM-VSI control, leading to torque harmonic of low order, are described in the paper, and recommendations for their compensation are given.
Series Compensation of Transmission Systems: A Literature Survey
Authors: Ordóñez Camilo Andrés , Gómez-Expósito Antonio , Maza-Ortega José María
Published: March 2021

This paper reviews the basics of series compensation in transmission systems through a literature survey. The benefits that this technology brings to enhance the steady state and dynamic operation of power systems are analyzed. The review outlines the evolution of the series compensation technologies, from mechanically operated switches to line- and self-commutated power electronic devices, covering control issues, different applications, practical realizations, and case studies. Finally, the paper closes with the major challenges that this technology will face in the near future to achieve a fully decarbonized power system.
High-Resolution Estimates of Fire Severity—An Evaluation of UAS Image and LiDAR Mapping Approaches on a Sedgeland Forest Boundary in Tasmania, Australia
Authors: Hillman Samuel , Hally Bryan , Wallace Luke , Turner Darren , Lucieer Arko , Reinke Karin , Jones Simon
Published: March 2021

With an increase in the frequency and severity of wildfires across the globe and resultant changes to long-established fire regimes, the mapping of fire severity is a vital part of monitoring ecosystem resilience and recovery. The emergence of unoccupied aircraft systems (UAS) and compact sensors (RGB and LiDAR) provide new opportunities to map fire severity. This paper conducts a comparison of metrics derived from UAS Light Detecting and Ranging (LiDAR) point clouds and UAS image based products to classify fire severity. A workflow which derives novel metrics describing vegetation structure and fire severity from UAS remote sensing data is developed that fully utilises the vegetation information available in both data sources. UAS imagery and LiDAR data were captured pre- and post-fire over a 300 m by 300 m study area in Tasmania, Australia. The study area featured a vegetation gradient from sedgeland vegetation (e.g., button grass 0.2m) to forest (e.g., Eucalyptus obliqua and Eucalyptus globulus 50m). To classify the vegetation and fire severity, a comprehensive set of variables describing structural, textural and spectral characteristics were gathered using UAS images and UAS LiDAR datasets. A recursive feature elimination process was used to highlight the subsets of variables to be included in random forest classifiers. The classifier was then used to map vegetation and severity across the study area. The results indicate that UAS LiDAR provided similar overall accuracy to UAS image and combined (UAS LiDAR and UAS image predictor values) data streams to classify vegetation (UAS image: 80.6%; UAS LiDAR: 78.9%; and Combined: 83.1%) and severity in areas of forest (UAS image: 76.6%, UAS LiDAR: 74.5%; and Combined: 78.5%) and areas of sedgeland (UAS image: 72.4%; UAS LiDAR: 75.2%; and Combined: 76.6%). These results indicate that UAS SfM and LiDAR point clouds can be used to assess fire severity at very high spatial resolution.
Heat and Mass Transfer Analysis on Magneto Micropolar Fluid Flow with Heat Absorption in Induced Magnetic Field
Authors: Haque Md. Mohidul
Published: March 2021

Heat and mass transfer due to a magneto micropolar fluid flow along a semi-infinite vertical plate bounded by a porous medium are investigated in presence of induced magnetic field. In case of cooling flow, heat and mass fluxes from the plate are subjected to be constant under the action of a constant heat sink. Mathematical model related to the problem is developed from the basis of studying magnetohydrodynamics (MHD) for both lighter and heavier particles. Dimensionless model of momentum, microrotation, induction, energy and concentration equations are solved simultaneously by the explicit scheme of finite difference technique. According to the obtained stability and convergence criteria of this transient flow, very negligible time step (Δt = 0.002) compared to the existing works has been taken to perform the numerical computation. Quantities of chief physical interest of the flow as shear stress, couple stress, current density, Nusselt number and Sherwood number are also studied here. The numerically computed results are compared with published results of available research works. Interestingly an excellent agreement is found with finite difference solutions in both explicit and implicit schemes. In order to discuss the physical aspects of the problem, the flow variables for different values of associated parameters are illustrated in graphs. Finally, important findings of the study are listed as concluding remarks.
The Role of Cultural Capital on the Voluntary Contributions to Cultural Goods: A Differential Game Approach
Authors: Finocchiaro Castro Massimo , Mazza Isidoro , Romeo Domenica
Published: March 2021

This study aims to offer a formal analysis which relates provision of cultural goods to the society’s level of cultural capital. Such a level is assumed to already exist in society and is increasable thanks to individual support for the offer of cultural goods. The achievement of the highest levels of cultural capital increases satisfaction coming from cultural goods consumption, and then voluntary contributions. Social approval, deriving from donations, is positively related to society’s existing cultural capital and triggers a positive externality for donators, thus increasing contributions and generating a positive externality for the whole society. The dynamic analysis provided in this study requires the adoption of a differential game where individuals interact, making their choices on their voluntary contribution level. We find that, under certain conditions, the solution obtained for the Nash equilibrium with closed-loop strategies provides optimal level of cultural capital that exceed the Pareto efficient solution obtained through open-loop strategies.
Genetic Variation of the Serine Acetyltransferase Gene Family for Sulfur Assimilation in Maize
Authors: Zhao Zhixuan , Li Shuai , Ji Chen , Zhou Yong , Li Changsheng , Wang Wenqin
Published: March 2021

Improving sulfur assimilation in maize kernels is essential due to humans and animals’ inability to synthesize methionine. Serine acetyltransferase (SAT) is a critical enzyme that controls cystine biosynthesis in plants. In this study, all SAT gene members were genome-wide characterized by using a sequence homology search. The RNA-seq quantification indicates that they are highly expressed in leaves, other than root and seeds, consistent with their biological functions in sulfur assimilation. With the recently released 25 genomes of nested association mapping (NAM) founders representing the diverse maize stock, we had the opportunity to investigate the SAT genetic variation comprehensively. The abundant transposon insertions into SAT genes indicate their driving power in terms of gene structure and genome evolution. We found that the transposon insertion into exons could change SAT gene transcription, whereas there was no significant correlation between transposable element (TE) insertion into introns and their gene expression, indicating that other regulatory elements such as promoters could also be involved. Understanding the SAT gene structure, gene expression and genetic variation involved in natural selection and species adaption could precisely guide genetic engineering to manipulate sulfur assimilation in maize and to improve nutritional quality.
The Important Role of N6-methyladenosine RNA Modification in Non-Small Cell Lung Cancer
Authors: Cheng Yue , Wang Meiqi , Zhou Junliang , Dong Huanhuan , Wang Shuqing , Xu Hui
Published: March 2021

N6-methyladenosine (m6A) is one of the most prevalent epigenetic modifications of eukaryotic RNA. The m6A modification is a dynamic and reversible process, regulated by three kinds of regulator, including m6A methyltransferases, demethylases and m6A-binding proteins, and this modification plays a vital role in many diseases, especially in cancers. Accumulated evidence has proven that this modification has a significant effect on cellular biological functions and cancer progression; however, little is known about the effects of the m6A modification in non-small cell lung cancer (NSCLC). In this review, we summarized how various m6A regulators modulate m6A RNA metabolism and demonstrated the effect of m6A modification on the progression and cellular biological functions of NSCLC. We also discussed how m6A modification affects the treatment, drug resistance, diagnosis and prognosis of NSCLC patients.
Seroprevalence of Anti-SARS-CoV-2 Antibodies in a Random Sample of Inhabitants of the Katowice Region, Poland
Authors: Zejda Jan E. , Brożek Grzegorz M. , Kowalska Małgorzata , Barański Kamil , Kaleta-Pilarska Angelina , Nowakowski Artur , Xia Yuchen , Buszman Paweł
Published: March 2021

Lack of knowledge around seroprevalence levels of COVID-19 in Poland was the reason for the implementation of a seroepidemiological study in the Katowice Region (2,100,000 inhabitants). In October–November 2020, a questionnaire examination and measurement of anti-SARS-CoV-2 IgG and IgM antibodies were performed in a random sample of the general population (n = 1167). The objectives of the study were to estimate the prevalence of IgG and IgM antibodies and to assess their host-related correlates. The prevalence of IgG seropositivity was 11.4% (95% CI: 9.5–13.2%) and IgM seropositivity was 4.6% (95% CI: 3.5–5.8%). Diagnosis of COVID-19 was found in 4.8% of subjects. A positive IgG test was statistically significantly associated with age (inverse relationship), a person’s contact with a COVID-19 patient, quarantine, and two symptoms in the past: fever and loss of smell/taste. Positive IgG tests were less prevalent in subjects who had diagnoses of arterial hypertension, diabetes, or rheumatologic disorders. IgM test positivity was associated with quarantine and loss of smell/taste only with no effect of chronic diseases found. In Poland, in the period October–November 2020, the prevalence of SARS-CoV-2 infection was larger than earlier estimates obtained in other European countries, probably reflecting the measurements obtained during the “second wave” of the epidemic.
Relationships of Adolescent and Young Couples with Violent Behaviors: Conflict Resolution Strategies
Authors: Aguilera-Jiménez Noelia , Rodríguez-Franco Luis , Rohlfs-Domínguez Paloma , Alameda-Bailén Jose Ramón , Paíno-Quesada Susana G.
Published: March 2021

Violence in adolescent and young couples is a major issue given its high prevalence and the serious consequences that it brings. For this reason, this research has stated two main objectives. In the first place, to ascertain the level of agreement between both members of the couple both with regard to occurrence and frequency of violence. Second, to ascertain the level of agreement on the frequency of use of conflict resolution strategies in problematic situations in 141 heterosexual couples. The age of the sample was between 17 and 30. The tools used were the DVQ-R questionnaire and the Spanish adaptation by Bonache, Ramírez-Santana, and González-Mendez (2016) of the Inventory of Conflict Resolution Styles (CSRI)The results indicate that of the 141 couples in the sample, 112 were identified as violent, thus indicating a high prevalence of violence within their partner relationships. Regarding the levels of agreement and accordance, statistically significant discrepancies are reflected in the perception of violence between men and women, analyzing both roles (aggression and victimization). Finally, also noteworthy is use of the strategy of negative involvement in conflicts, with significant differences in relation to sex; it is the girls who make the most use of this strategy, and the high level of agreement on the frequency of problem-solving is reflected on that strategy.
Associations between Disability and Infertility among U.S. Reproductive-Aged Women
Authors: Ha Sandie , Martinez Valerie
Published: March 2021

We aim to evaluate the association between self-reported disabilities and infertility and whether disabilities are associated with decreased likelihood of seeking infertility-related care. This US nationally representative cross-sectional analysis includes 3789 non-pregnant women aged 18–49 years without history of hysterectomy or oophorectomy (NHANES, 2013–2018). Disabilities and infertility were both self-reported in personal interviews with trained interviewers. Logistic regression models estimated the adjusted odds ratio (aOR) and 95% confidence intervals for the association between disabilities and infertility and related care seeking. Models adjusted for potential confounders and complex probability sampling. Compared to women without disabilities, women with disabilities (WWD) had higher odds of infertility (aOR: 1.78 (1.31–2.40)). Similar findings were observed for sensory (2.32 (1.52–3.52)) and cognitive disabilities (1.77 (1.28–2.44)). Among women with infertility, WWD were less likely to seek infertility-related care (0.68 (0.32–1.44)) but these estimates were not statistically significant. WWD have increased odds of reporting infertility, and if affected, are less likely to visit a health care provider for this condition. While more research is needed to understand reproductive health issues and needs among WWD, it is important to push for more equitable policies and practices to address the health needs of this underserved population.
Reliability and Validity of the Treatment Satisfaction with Medicines Questionnaire (SATMED-Q) in Persons with Arterial Hypertension
Authors: López-Torres López Jesús , Rabanales-Sotos Joseba , López-Torres Hidalgo María Rosa , Milián García Rosa María , López Martínez Consuelo , Blázquez Abellán Gemma
Published: March 2021

Objective: To evaluate the reliability and validity of the Treatment Satisfaction with Medicines Questionnaire (SATMED-Q) in persons with arterial hypertension undergoing pharmacological treatment, along with its convergent validity with degree of control of blood pressure levels, therapeutic adherence, and tolerability of antihypertensive drugs. Methods: Observational cross-sectional study conducted on a sample of 484 persons. Treatment satisfaction was evaluated with the SATMED-Q, an instrument consisting of 17 items with six dimensions. Other variables were blood pressure, antihypertensive drugs, adverse effects, therapeutic adherence, and participants’ characteristics. Results: Cronbach’s alpha was 0.916. Factor analysis revealed six factors that could account for 89.97% of total variance. The test–retest reliability analysis yielded an intraclass correlation coefficient of 0.910 (95% CI = 0.806–0.959). In a possible range of 0 through 100 points, participant satisfaction with treatment ranged from 38.2 to 100 (mean 79.9 (SD = 12.9; 95% CI = 78.8–81.0); median 80.9). SATMED-Q scores were higher among persons who reported experiencing no adverse effects (82.5 ± 11.6 SD vs. 68.7 ± 11.9 SD; p < 0.001). Satisfaction levels were significantly lower among subjects not complying with the treatment (73.2 ± 12.9 vs. 82.1 ± 12.1; p < 0.001), and significantly higher among those presenting with controlled blood pressure levels (82.1 ± 12.1 SD vs. 77.5 ± 13.3 SD; p < 0.001). Conclusions: The SATMED-Q showed high internal consistency and good stability in the reliability analysis. It is an appropriate instrument for evaluating satisfaction with antihypertensive treatment, both in routine clinical practice and in community pharmacy or clinical research settings.
Pseudomonas aeruginosa: An Audacious Pathogen with an Adaptable Arsenal of Virulence Factors
Authors: Jurado-Martín Irene , Sainz-Mejías Maite , McClean Siobhán
Published: March 2021

Pseudomonas aeruginosa is a dominant pathogen in people with cystic fibrosis (CF) contributing to morbidity and mortality. Its tremendous ability to adapt greatly facilitates its capacity to cause chronic infections. The adaptability and flexibility of the pathogen are afforded by the extensive number of virulence factors it has at its disposal, providing P. aeruginosa with the facility to tailor its response against the different stressors in the environment. A deep understanding of these virulence mechanisms is crucial for the design of therapeutic strategies and vaccines against this multi-resistant pathogen. Therefore, this review describes the main virulence factors of P. aeruginosa and the adaptations it undergoes to persist in hostile environments such as the CF respiratory tract. The very large P. aeruginosa genome (5 to 7 MB) contributes considerably to its adaptive capacity; consequently, genomic studies have provided significant insights into elucidating P. aeruginosa evolution and its interactions with the host throughout the course of infection.
Functional Characterisation of Three Glycine N-Acyltransferase Variants and the Effect on Glycine Conjugation to Benzoyl–CoA
Authors: Rohwer Johann M. , Schutte Chantelle , van der Sluis Rencia
Published: March 2021

The glycine conjugation pathway in humans is involved in the metabolism of natural substrates and the detoxification of xenobiotics. The interactions between the various substrates in this pathway and their competition for the pathway enzymes are currently unknown. The pathway consists of a mitochondrial xenobiotic/medium-chain fatty acid: coenzyme A (CoA) ligase (ACSM2B) and glycine N-acyltransferase (GLYAT). The catalytic mechanism and substrate specificity of both of these enzymes have not been thoroughly characterised. In this study, the level of evolutionary conservation of GLYAT missense variants and haplotypes were analysed. From these data, haplotype variants were selected (156Asn > Ser, [17Ser > Thr,156Asn > Ser] and [156Asn > Ser,199Arg > Cys]) in order to characterise the kinetic mechanism of the enzyme over a wide range of substrate concentrations. The 156Asn > Ser haplotype has the highest frequency and the highest relative enzyme activity in all populations studied, and hence was used as the reference in this study. Cooperative substrate binding was observed, and the kinetic data were fitted to a two-substrate Hill equation. The coding region of the GLYAT gene was found to be highly conserved and the rare 156Asn > Ser,199Arg > Cys variant negatively affected the relative enzyme activity. Even though the 156Asn > Ser,199Arg > Cys variant had a higher affinity for benzoyl-CoA (s0.5,benz = 61.2 µM), kcat was reduced to 9.8% of the most abundant haplotype 156Asn > Ser (s0.5,benz = 96.6 µM), while the activity of 17Ser > Thr,156Asn > Ser (s0.5,benz = 118 µM) was 73% of 156Asn > Ser. The in vitro kinetic analyses of the effect of the 156Asn > Ser,199Arg > Cys variant on human GLYAT enzyme activity indicated that individuals with this haplotype might have a decreased ability to metabolise benzoate when compared to individuals with the 156Asn > Ser variant. Furthermore, the accumulation of acyl-CoA intermediates can inhibit ACSM2B leading to a reduction in mitochondrial energy production.