bluuebunny/crossref_metadata_2025 huggingface dataset:
Gentrifying Force or a Force for Environmental Justice? A National Assessment of Brownfield Redevelopment and Gentrification in the United States from 2006 to 2015
Authors: Becerra Marisol
Published: December 2022

Cities in the United States (U.S.) are increasingly developing sustainability initiatives to improve local economies while addressing environmental concerns. Since 1990, the U.S. Environmental Protection Agency’s (EPA) Brownfield Revitalization Program has encouraged the remediation of postindustrial sites to create new areas for real estate development. However, previous research demonstrates that industrial areas are more likely to be in predominantly poor and racial/ethnic minority communities. A central argument favoring redevelopment is that remediation helps mitigate environmental inequality and achieve environmental justice for aggrieved communities. Still, very little research examines if and how these communities benefit from these changes. This article examines this question by reviewing the related literature and applying insights to a quasi-experimental analysis of brownfield redevelopment’s impact on racial/ethnic composition and income levels of neighborhoods. Publicly available data were acquired from the EPA Cleanups in My Community data portal and the 5-Year American Community Survey—released annually from 2006 to 2015—to examine demographic changes in neighborhoods where brownfield redevelopment occurred. The study implements a difference-in-differences model using two-way fixed effects regression models on a panel data set of 4,740 census tracts in 48 contiguous U.S. states (or Lower 48 states). This study’s findings suggest that wealthier White and Latino populations are more likely to benefit from brownfield redevelopment than Black populations in affected neighborhoods.
Challenges and Barriers to Providing Primary Care to Children of South Asian Origin: Pediatricians’ Perspectives
Authors: Ramachandran Usha , Mahajan Kaavya , Shah Aashiki , Ghoshal Bishakha , Khurshid Afrida , Desilva Nilifa , Shiriti Margia , Patel Nolan , Gaur Sunanda , Karasz Alison
Published: December 2022

South Asian (SA) Americans have a high risk of metabolic and cardiovascular disease. Prevention efforts should start in childhood and should be culturally appropriate. We sought to understand the challenges and barriers that pediatricians face in providing care for SA children to inform professional education on culturally effective care. Qualitative interviews were conducted with a diverse sample (N = 17) of pediatricians. Challenges reported included feeding problems, inadequate physical activity, and mental health concerns. Communication barriers included parents’ anxiety around feeding, influence of grandparents, stigma around mental health, and cultural communication gaps. Effective strategies included clear communication, a gradual approach, ensuring buy-in from grandparents, greater attention to family history, and improved cultural knowledge in pediatrician. Addressing feeding problems was the most mentioned challenge, which is especially concerning given the high chronic disease risk in SAs. Education on culturally appropriate strategies can equip pediatricians to effectively counsel SA families to address these risks.
Psalm body help us: Hearing the lament of health care professionals
Authors: Harootunian-Cutts Jacquelyn , Deters Samuel
Published: December 2022

The COVID-19 pandemic has led to burdensome moral distress for health care professionals in the United States. Despite being initially hailed as “heroes” by the American public, health care professionals have encountered unique barriers to healing in the context of the devastating pandemic. Unfortunately, the health care system was ill-equipped to deal with the dramatic surge in moral distress caused by the pandemic. The church, and faith-based health care systems, can play a crucial role for hearing the lament of morally distressed health care professionals and attending to them as a community toward moral reintegration. We suggest that the Psalms offer an entry point both for those who need to express their lament of moral distress and those who accompany health care professionals in seeking structural changes, advocating for needed resources for patient care, and attaining the important goal of spiritual healing.
COVID-19 and algorithmic medical ethics: A Christian perspective
Authors: Childs Brian H.
Published: December 2022

Triage plans which were largely developed in the face of the growing and lethal pandemic betrayed an underlying anthropology which unintentionally neglected to allow for the assignment of potentially limited interventions to underserved and less socially advantaged persons. This neglect is abetted by the structure of US medical delivery that treats medical care as a commercial commodity with an emphasis on high tech rescue medicine as opposed to preventive public health medicine. A Christian anthropology modeled by Karl Barth’s notion of analogia relationis would correct this neglect of the underserved and needy.
Exploring social determinants of health: COVID-19 vaccine challenges and solutions
Authors: Johnson Kirk A. , Pilkington Bryan
Published: December 2022

The Coronavirus (COVID-19) pandemic has negatively shifted the foundations of human health and the well-being of humanity on a global scale. Its contagiousness and lethal symptoms pose a threat to everyone, especially seniors over 65 years, immunocompromised individuals, and people with preexisting health conditions. The factors of the social determinants of health had great influence on the vaccination status for Black and Brown communities. Access to life-saving treatment and resources was hindered by the poor social determinants and socioeconomic status, which led to slow vaccination numbers. This article examines that equitable vaccination access, distribution, and health literacy in Black and Brown communities are all supported by careful analysis of the notion of dignity.
We need more kidneys: Living donation, BMI, and Black mortality from renal disease
Authors: Rapela Heidt Mari
Published: December 2022

Renal disease is an endemic problem within the United States, with about 10% of the population afflicted with kidney problems that range from minor to life-threatening. Black Americans are especially affected by kidney disease, with a high proportion of those affected needing a kidney transplant. While kidney transplants are very common, a shortage of donated kidneys exists, causing many people to turn to directed living donation, through which family members or friends volunteer to donate a healthy kidney to a specific person. This essay examines racial bias in the evaluation of living donors, especially the bias associated with body mass index. The requirement for a “normal weight” prevents many African American volunteers from donating, leading to a higher mortality rate than necessary for Black kidney transplant patients.
The Maze Runner, the pandemic, and the Gospel
Authors: Hamilton Nick
Published: December 2022

The Maze Runner book series and movie trilogy is set in the future, when ecological disaster and a global pandemic strike. Many children and young adults are immune to the disease and are therefore quarantined, studied, and used to develop a cure for the “flare.” This article examines some of the ethical frameworks experienced in the COVID-19 pandemic using the Maze Runner movies as illustrations. It also examines contemporary culture and proposes that a more robust gospel witness is needed to better deal with future global pandemics.
Slums, Villas Miseria, and Barriadas: Why Terms Matter
Authors: Massidda Adriana Laura
Published: December 2022

Building upon previous debates surrounding the English-language term slum, this article argues that slum stigmatizes the spaces and subjects that it refers to not only because it evokes nineteenth-century imaginaries of pauperism and crime but also for the sweeping gesture that it implies; for its refusal to observe in depth the experience of those who inhabit the spaces at stake and the interests associated. Intended as a universal term, “slum” can refer to such disparate urban typologies as inner-city high-rise tenements, low-rise overcrowded housing, and peripheral shantytowns, which empties it of specific meaning and converts it into an abstract container on to which external agendas are projected. To further demonstrate this point, the article reads slum alongside the seemingly analogous yet more specific Argentine and Peruvian terms villas miseria, barriadas and pueblos jóvenes, fields of dispute whose meanings have been contested by different actors, including residents, from the outset.
Stealthy replay attack detection of 3-DOF helicopter benchmark system using dynamic watermarking approach
Authors: Li Wei , Qian Hai , Zhang Min , Wang Sumei , Wang Feng , Zhu Xiaoyuan
Published: December 2022

Cyber security for unmanned systems has drawn tremendous research attention in recent years owing to its priority in ensuring system performance and safety. This paper presents a dynamic watermarking-based active detection approach for unmanned helicopter system under stealthy replay attacks. First, the dynamic model of the 3-DOF helicopter and the replay attack model are constructed, respectively. Statistical analysis is conducted using Kalman filter residuals to interpret the concealment of stealthy replay attacks for a system under intrusion. Then, as traditional chi-square detector is unable to detect stealthy replay attacks, an active detector by incorporating dynamic watermarking with the chi-square detector is explored. Finally, by conducting simulations of the detection procedures under different test scenarios comparatively using traditional chi-square detector and the proposed approach, the effectiveness and merits of the watermarking approach is verified sufficiently. The watermarking-based approach is promising in comprehensive detections against stealthy replay attacks for enhancing system security.
Improvement in Heart Failure Self-Care and Patient Readmissions with Caregiver Education: A Randomized Controlled Trial
Authors: Clements Linda , Frazier Susan K. , Lennie Terry A. , Chung Misook L. , Moser Debra K.
Published: December 2022

Caregivers support heart failure (HF) self-care with little HF education. The purpose of this study was to evaluate the effectiveness of a caregiver-only educational intervention aimed at improving caregiver self-efficacy, perceived control, and HF knowledge, as well as patient self-care and 30-day cardiac readmission. In total, 37 patients and their caregivers were randomly assigned to a control condition or a caregiver-only educational intervention with telephone follow-up. Outcomes included patient 30-day cardiac readmission, patient self-care, caregiver self-efficacy, caregiver perceived control, and caregiver HF knowledge. Linear mixed model, Kaplan–Meier, and Cox regression analyses were used to determine the effects of the intervention on outcomes. Self-care maintenance ( p = 0.002), self-care management ( p = 0.005), 30-day cardiac readmission ( p = 0.003), and caregiver perceived control ( p < 0.001) were significantly better in the intervention group. The results suggest that interventions targeting caregiver HF education could be effective in improving HF patients’ 30-day cardiac readmissions, patient self-care, and caregiver perceived control.
Food engineers’ attitudes and purchasing intentions towards genetically modified organism products
Authors: Mutlu Hayrettin , Ay Murat , Doğan Murat
Published: December 2022

Background: Biotechnological developments have resulted in the modification of the genetic structures of many organisms. However, the possibility of risks in terms of human health has caused consumers to approach products containing genetically modified organisms (GMOs) with suspicion. Objective: In this study, we aimed to determine the attitudes of food engineers towards GMO products and their effects on purchase intentions. Methods: For this purpose, an attitude scale towards GMO products was adapted, and a multivariate regression analysis was performed by applying the adapted questionnaire. Results: It has been determined that the negative attitudes of food engineers towards GMO products and their purchasing intentions have an effect. Attitudes toward the use of gene technology in production were determined with 17% as the most effective dimension of purchase intention, and it was found to have a significant effect ( p < 0.05). Conclusions: Overall, it was determined that food engineers were concerned about the potential risk of GMO foods. In order to overcome these concerns, it is thought that eliminating the lack of knowledge of this professional group on gene technology should be planned as a strategic goal.
Utilizing Clinical Trial Data to Assess Timing of Surgical Treatment for Emphysema Patients
Authors: Alimohammadi Maryam , Chaovalitwongse W. Art , Vesselle Hubert J. , Zhang Shengfan
Published: December 2022

Background

Lung volume reduction surgery (LVRS) and medical therapy are 2 available treatment options in dealing with severe emphysema, which is a chronic lung disease. However, or there are currently limited guidelines on the timing of LVRS for patients with different characteristics.

Objective

The objective of this study is to assess the timing of receiving LVRS in terms of patient outcomes, taking into consideration a patient’s characteristics.

Methods

A finite-horizon Markov decision process model for patients with severe emphysema was developed to determine the short-term (5 y) and long-term timing of emphysema treatment. Maximizing the expected life expectancy, expected quality-adjusted life-years, and total expected cost of each treatment option were applied as the objective functions of the model. To estimate parameters in the model, the data provided by the National Emphysema Treatment Trial were used.

Results

The results indicate that the treatment timing strategy for patients with upper-lobe predominant emphysema is to receive LVRS regardless of their specific characteristics. However, for patients with non–upper-lobe–predominant emphysema, the optimal strategy depends on the age, maximum workload level, and forced expiratory volume in 1 second level.

Conclusion

This study demonstrates the utilization of clinical trial data to gain insights into the timing of surgical treatment for patients with emphysema, considering patient age, observable health condition, and location of emphysema.

Highlights

Both short-term and long-term Markov decision process models were developed to assess the timing of receiving lung volume reduction surgery in patients with severe emphysema. How clinical trial data can be used to estimate the parameters and obtain short-term results from the Markov decision process model is demonstrated. The results provide insights into the timing of receiving lung volume reduction surgery as a function of a patient’s characteristics, including age, emphysema location, maximum workload, and forced expiratory volume in 1 second level.
Risk factors for fracture in patients with fibrous dysplasia of the proximal femur
Authors: Liu Wenzheng , Xu Ming , Yu Xiuchun
Published: December 2022

Objective

The primary aim of this retrospective observational clinical study was to explore the risk factors for fracture in patients with fibrous dysplasia (FD) of the proximal femur.

Methods

We investigated body mass index, bilateral radiographs on both sides, femoral neck shaft angle measurements, and markers of bone metabolism in patients with FD of the proximal femur according to whether or not they had sustained a hip fracture. Nine clinical parameters (age, sex, clinical classification, anatomic classification, femoral neck shaft angle, and procollagen type 1 N-terminal propeptide, C-terminal telopeptide of type I collagen, and osteocalcin levels) were selected for univariate analysis. Factors that were significant in univariate analysis were then subjected to multivariate logistic analysis.

Results

Clinical classification, anatomic classification, femoral neck shaft angle, and the osteocalcin level were identified to be statistically significant risk factors for fracture in univariate analysis. Anatomic classification, femoral neck shaft angle, and the osteocalcin level remained significant risk factors in multivariate analysis.

Conclusions

Anatomic classification, femoral neck shaft angle, and the osteocalcin level are important risk factors for fracture in patients with FD of the proximal femur and could be used to guide implementation of a fracture prevention strategy in these patients.
Clinical value of offering multiple chemotherapy lines to a luminal-like metastatic breast cancer: A case report with eribulin
Authors: Valsecchi Anna Amela , Paparo Jessica , Pirro Valeria , Manfredi Matteo , Di Maio Massimo , Dionisio Rossana
Published: December 2022

Introduction:

The achievement of complete response with chemotherapy after multiple treatment lines in metastatic breast cancer and the chemosensitivity in a luminal-like breast cancer are two important issues as it is often asked whether there is a potential limit to the number of therapeutic lines offered and what clinical value they may have. In this setting, eribulin mesylate is a chemotherapy option available. Several randomized and observational studies demonstrated eribulin’s meaningful improvement on prolongation of survival, chronicling the disease and preventing the onset of new metastases, although the rate of complete responses is rather limited.

Case description:

We report the five-year history of a luminal A breast cancer, stage IV at diagnosis, metastasized to bone and brain. After undergoing four chemotherapy lines and several radiotherapy sessions with partial response as the best response on bone and with a complete response on brain, our patient finally achieved a metabolic complete response also on bone after about a year of fifth-line treatment with eribulin. Currently the patient is in close clinical and radiological follow-up.

Conclusions:

This case report aims to emphasize the clinical value of a chronic chemotherapy treatment also in heavily pretreated and luminal-like metastatic breast cancer, supporting eribulin as a good choice to consider.
Maritime Inventory Routing Problem Considering Weather Conditions and Tide at Ports
Authors: Radan F. , Fatemi Ghomi S. M. T. , Mirzapour Al-e-hashem S. M. J. , Sammak Jalali Moeen
Published: December 2022

The maritime inventory routing problem (MIRP) has gained attention in several aspects during the last decades. The problem has numerous variations, typically instigated from real-world complications. This paper addresses MIRP to meet demand in different ports within the defined planning horizon. A mixed integer nonlinear programming model is developed with respect to different planning and routing constraints, loading/unloading restrictions, wave and wind forces limitations, tide constraints, and ship capacity constraints. To study the effects of wave angle, wind force, and tide, the top ten important ports in Iran and nearby ports have been considered as a sample. Optimization of the ship route is also done with respect to the weather conditions and tide. The results indicate that wind force and wave angle do not affect the routing and only change the ship speed and costs. The tide influences the route of vessels and also increases costs.
Companions’ Chronicles: Experiences of Home Care Workers in the Community Elder Care (Companion) Program in Barbados
Authors: Odle-James Thérèse , Willie-Tyndale Douladel
Published: December 2022

The home care workforce contributes significantly to older adults’ health and well-being. The Community Elder Care (Companion) Program in Barbados employs Companions to engage with socially isolated older adults in their homes for a few hours per day. In this qualitative study we explored Companions’ experiences in the program 1 year since its commencement. Opportunity to earn, love and concern for older adults, and previous caregiving experiences were among the factors which motivated participants to seek employment in the program. They commonly reported going beyond the scope of their duties to meet clients’ critical needs. While they saw themselves as positively impacting their clients, some noted that they too benefitted from the engagement. Better compensation packages and training were seen as necessary actions for program improvement. Our findings can be incorporated in a comprehensive program review and can inform home care workforce development and Companion Program structure and delivery.
Redesigning and numerical simulation of gating system to reduce cold shut defect in submersible pump part castings
Authors: Kumar J Yokesh , Gopi S , Amirthagadeswaran KS
Published: December 2022

Gating system design is an essential element in casting that significantly affects the melt's molten metal flow behaviour, heat transfer, and solidification. Improper gating system leads to pouring-related defects like cold shut, misrun, etc. Submersible pump-bearing block castings produced in one of the leading foundries are rejected due to a cold shut defect. It was identified that the improper gating system is the probable cause for rejection. The bearing block and the existing gating system were modelled in 3D modelling software, and the molten metal flow behaviour of casting was simulated with casting simulation software. Based on the simulation results, the existing gating system was redesigned following established empirical relations. The component with the revised gating system was analysed for flow behaviour through simulation with the software. With the revised gating system, elimination of cold shut is observed, and the revised gating design is recommended to the industry for implementation. The effectiveness of the revised gating system is also validated with pump diffuser casing, which has similar geometrical and material characteristics. The simulation results and experimental validation showed a reduction in flow and surface defects. Appropriate design of the gating system and balanced arrangement of cavities in the gating system are noted to reduce the flow and surface-related defects. It is observed that with the revised gating systems, the percentage of rejection is reduced from 28.36% to 2.34% and 23.43% to 2.45% for the bearing block and pump diffuser casing respectively.
CircLPAR3 knockdown suppresses esophageal squamous cell carcinoma cell oncogenic phenotypes and Warburg effect through miR-873-5p/LDHA axis
Authors: Cheng Yao , Ma Zhenchuan , Liu Shiyuan , Yang Xiaoping , Li Shaomin
Published: December 2022

Background

Circular RNAs (circRNAs) have been identified to participate in regulating multiple malignancies. Herein, this study aimed to explore the clinical significance, biological function, and regulatory mechanisms of circRNA lysophosphatidic acid receptor 3 (circLPAR3) in esophageal squamous cell carcinoma (ESCC) cell malignant phenotypes and Warburg effect.

Methods

The qRT-PCR and Western blot were used to detect the levels of genes and proteins. Glucose uptake and lactate production were detected to determine the Warburg effect. The effects of circLPAR3 on ESCC cell proliferation, apoptosis, and metastasis were evaluated by MTT, 5-ethynyl-2′-deoxyuridine (EdU), flow cytometry, wound healing, and transwell assays. The binding interaction between miR-873-5p and circLPAR3 or lactate dehydrogenase A (LDHA) was verified using dual-luciferase reporter and RIP assays. Xenograft mice models were established to conduct in vivo analysis.

Results

CircLPAR3 is a stable circRNA and was increased in ESCC tissues and cells. Functionally, circLPAR3 knockdown suppressed ESCC cell Warburg effect, proliferation, metastasis, and induced apoptosis in vitro, and impeded xenograft tumor growth and Warburg effect in ESCC mice models. Mechanistically, circLPAR3 served as a sponge for miR-873-5p, which targeted LDHA. Moreover, circLPAR3 could regulate LDHA expression by sponging miR-873-5p. Thereafter, rescue experiments suggested that miR-873-5p inhibition reversed the anticancer effects of circLPAR3 silencing on ESCC cells. Furthermore, miR-873-5p overexpression restrained ESCC cell Warburg effect and oncogenic phenotypes, which were abolished by LDHA up-regulation.

Conclusion

CircLPAR3 knockdown suppressed ESCC cell growth, metastasis, and Warburg effect by miR-873-5p/LDHA axis, implying a promising molecular target for ESCC therapy.
Infectious crystalline keratopathy following Descemet's stripping automated endothelial keratoplasty
Authors: Seth Ishith , Bulloch Gabriella , Roberts Philipp K , Vajpayee Rasik B.
Published: December 2022

Introduction

We describe this first case of Staphylococcus epidermidis causing infectious crystalline keratopathy (ICK) following Descemet stripping endothelial keratoplasty (DSAEK), that resolved after 5 weeks of topical antibiotic and corticosteroid treatment.

Case Description

An 80-year-old woman presented with blurred vision, redness, and ocular pain 9 months after successful DSAEK. Slit lamp examination revealed the presence of white, non-suppurative, deep-branching stromal infiltrates, and a clinical diagnosis of ICK was made. Cultures of corneal scapings isolated multidrug-resistant Staphylococcus epidermidis. No subsequent surgical procedures were performed. Based on antibiotic sensitivity analysis, she was treated successfully with topical vancomycin and chloramphenicol for 5 weeks. Complete resolution of the infection with minor anterior stromal corneal scarring of the host cornea was noted after 5 weeks of treatment. This case report describes the diagnosis and management of ICK after DSAEK and reviews the relevant literature regarding the occurrence of ICK after DSAEK.

Conclusion

In this case, vancomycin and chloramphenicol allowed for the uncomplicated resolution of infection with only minor visual impairment from baseline.
Latin American perspectives on Indigenous social work: in search of mind, body, and soul
Authors: da Luz Scherf Erick
Published: December 2022

Despite sharing different cultures, customs, and pasts, Indigenous peoples in Latin America often face similar problems such as eviction from their ancestral lands, persecution, cultural genocide, and loss of their livelihoods. Yet, their knowledges and socio-cultural practices persist and have a lot to contribute to social work theory and practice despite being largely overlooked in Eurocentric and western social work curricula and formal education. Even though Indigenous social work has become a more popularized topic, the mainstream literature on the subject has often ignored the experiences of Latin American countries. Considering that, the aims of this article are at exploring, mapping, and presenting a synthesis of main concepts, trends, and values that could orientate social workers in their practice with Indigenous people and communities in the region of Latin America.
The outcome of primary per oral endoscopic myotomy (POEM) for treatment of achalasia: Norwegian single-center experience with long-term follow-up
Authors: Pham Khanh Do-Cong , Lauritzen Sigurd Strumse , Tjora Erling , Gilja Odd Helge , Hatlebakk Jan Gunnar , Aßmus Jörg , Havre Roald Flesland
Published: December 2022

Background and aims:

Per oral endoscopic myotomy (POEM) has become an established treatment for achalasia, but no Scandinavian studies with long-term follow-up exist. This study from a tertiary referral center in Norway investigates the short-, mid-, and long-term feasibility, safety, efficacy, and complications of POEM.

Methods:

Prospective data from the first 84 patients who underwent POEM from 2014 to 2019 were analyzed. The median follow-up time was 44 months. Clinical success was defined as the Eckardt score (ES) ⩽3, and reflux as pathological if the acid exposure time (pH < 4) was more than 6%. ES was used for symptom evaluation before, and at 6, 12, and up to 64 months after POEM.

Results:

A total of 50 males and 34 females were included. A total of 43 (51%) were treatment naïve, 24 (28.6%) had been previously treated with botulinum toxin, pneumatic balloon dilatation, or both, and 17 (20.2%) were previously treated with Heller’s myotomy. The median post-POEM ES at 12 months was 1 (0–9), compared to pre-POEM 7 (4–12) (p < 0.01). At 12 months after POEM, clinical success persisted in 74 patients (88.1%). Clinical success was the highest for patients who were naïve to treatment, 41/43 (95%), and lower for those previously treated with Heller’s myotomy 12/17 (70.6%). Long-term follow-up at 5–6 years of 42 patients showed a clinical success rate of 94%. We experienced adverse events in five patients (6%). Post-POEM pathological reflux was found in 46% (28/61). After 3–4 years, the median ES was 1, and after 5–6 years, it was 2.

Conclusion:

POEM was safe and relieved the symptoms of achalasia significantly and persistently. The procedure had a better outcome in treatment naïve than previously treated patients. However, POEM is associated with significantly increased esophageal acid exposure.

Twitter summary

Norwegian single-center study: POEM had a clinical success rate of 94% after 5–6 years since its introduction at the center in 2014, providing a safe and effective treatment for achalasia.
Co-Existence of An Unusual Branching Pattern of Celiacomesenteric Trunk With Complete Common Mesentery in a 48-Year-Old Man: A Case Report
Authors: Harrabi Fathia , Jabeur Methnani , Houssem Ammar , Abdelkader Mizouni , Mehdi Ben Latifa , Mohamed Amine Saiid , Mohamed Ben Mabrouk , Ali Ben Ali
Published: December 2022

Celiacomesenteric trunk (CMT) refers to the common origin of celiac trunk and superior mesenteric artery which is a very rare anatomical variation. CMT is incidentally diagnosed during angiography or abdominal computed tomography scanning. The diagnosis of CMT may inform surgical practice and prevent damage during invasive radiologic procedures, lowering thus the rate of iatrogenic errors. Complete common mesentery is in its turn a rarer congenital anomaly that arises from an abnormal rotation of primitive small intestine during embryonic development. We report a case of a 48-year-old man, suffering from chronic abdominal pain, and postprandial discomfort. The patient underwent an abdominal contrast-enhanced computed tomography that detected a CMT associated with common complete mesentery. According to our review of bibliography, this is the first case report to simultaneously report both congenital anomalies (CMT and common complete mesentery). Furthermore, the CMT described here has not been described in previous classifications and represent a novel anatomical variation of CMT.
Mannose-binding lectin gene polymorphism and the susceptibility of sepsis: A meta-analysis
Authors: Cheng Shaowen , Wang Rong , Zhu Hengjie , Yang Jian , Yao Jiangling , Zeng Yunfu , Cui Hongwang , Huang Binwen
Published: December 2022

Objective

To assess the association between the Mannose-binding lectin (MBL) gene polymorphism and the susceptibility to sepsis using a meta-analysis.

Methods

The publications were searched on PubMed, Embase, and Web of Science databases up to December 1, 2019 for relevant literature.

Results

A total of 32 studies (21 adult and 11 pediatric studies) were selected for analysis. Overall, in the three models of MBL +54 A/B gene polymorphisms, namely the dominant model BB + AB vs. AA ( p = 0.03), the recessive model BB vs. AB + AA ( p < 0.00001), and the allele model B vs. A ( p = 0.04), MBL +54 A/B was significantly related to the risk of sepsis. In the adult group, the MBL A/O gene polymorphism was associated with the risk of sepsis in the dominant model AO + OO vs. AA ( p = 0.006) as well as in the allele model O vs. A ( p = 0.04). The MBL +54 A/B gene polymorphism was significantly related to the risk of sepsis in the recessive model and, therefore, may increase the risk of sepsis. In the pediatric group, no polymorphic loci were significantly associated with sepsis in any of the three models. The results of the publication bias test demonstrated no publication bias in an unadjusted estimate of the relationship between MBL A/O and −211Y/X gene polymorphism and sepsis.

Conclusions

The polymorphisms of MBL that are related to the occurrence of sepsis are primarily A/O and +54 A/B, while −221Y/X and −550H/L have no clear relationship with the susceptibility of sepsis in various age groups or different models.
Validating the accuracy of a novel virtual reality platform for determining implant orientation in simulated primary total hip replacement
Authors: Howgate Daniel , Oliver Michael , Stebbins Julie , Roberts Patrick Garfjeld , Kendrick Ben , Rees Jonathan , Taylor Stephen
Published: December 2022

Introduction

Accurate acetabular cup and femoral stem component orientation are critical for optimising patient outcomes, reducing complications and increasing component longevity following total hip replacement (THR). This study aimed to determine the accuracy of a novel virtual reality (VR) platform in assessing component orientation in a simulated THR model.

Methods

The VR platform (HTC Vive Pro® system hardware) was compared against the validated Vicon® optical motion capture (MoCap) system. An acetabular cup and femoral stem were manually implanted across a range of orientations into pelvic and femur sawbones, respectively. Simultaneous readings of the acetabular cup operative anteversion (OA) and inclination (OI) and femoral stem alignment (FSA) and neck anteversion (FNA) were obtained from the VR and MoCap systems. Statistical analysis was performed using Pearson product-moment correlation coefficient (PPMCC) (Pearson’s r) and linear regression (R2).

Results

A total of 55 readings were obtained for the acetabular cup and 68 for the femoral stem model. The mean average differences in OA, OI, FSA and FNA between the systems were 3.44°, −0.01°, 0.01° and −0.04°, respectively. Strong positive correlations were demonstrated between both systems in OA, OI, FSA and FNA, with Pearson’s r = 0.92, 0.94, 0.99 and 0.99, and adjusted R2 = 0.82, 0.9, 0.98 and 0.98, respectively.

Conclusion

The novel VR platform is highly accurate and reliable in determining both acetabular cup and femoral stem component orientations in simulated THR models. This adaptable and cost-effective digital tracking platform may be modified for use in a range of simulated surgical training and educational purposes, particularly in orthopaedic surgery.
Educational Research Review From Diverse Perspectives: A Bibliometric Analysis of Web of Science (2011–2020)
Authors: Sezgin Aslıhan , Orbay Keziban , Orbay Metin
Published: December 2022

This study aims to reveal the bibliometric characteristics of publications on educational research from diverse perspectives, including the level of national-international collaborations, the percentage change in open-access papers, and interactions with other disciplines. Through bibliometric analysis, the data were collected from Web of Science (WoS), “Education and Educational Research (E&ER),”“Psychology, Educational (PE),”“Education, Special (ES)” and “Education Scientific Disciplines (ESD)” categories, during 2011 to 2020. The findings suggest that the number of publications in each category and the percentage of open-access publications have increased regularly. However, it was observed that categories, especially the ES category, were partially falling behind, as compared to the growth in WoS; while the ES and the PE categories were the highest regarding national-international collaborations over time. Both collaboration levels were the highest in the E&ER category. It was concluded that the multi-authorship trend has rapidly increased, the number of references has regularly increased, and specifically, the PE category has been distinguished from others in terms of the references used. Meanwhile, the change over time in the aggregate impact factor, calculated for each category as a measure of the widespread impact of the studies, pointed to inflation. The results show that educational research is becoming more organized and international, while less fragmented. Moreover, the findings support that educational research is interdisciplinary in essence and diverse in content.
Predictors of Graft Failure After Primary Medial Patellofemoral Ligament Reconstruction
Authors: Zhang Zhi-Jun , Dimeng Lin-qian , Cao Yan-wei , Zheng Tong , Song Guan-yang , Li Yue , Zhang Hui
Published: December 2022

Background:

The tibiofemoral rotation angle has been found to be higher in patients with recurrent patellar dislocations (RPDs) than in healthy people; however, little is known about the clinical significance of this finding.

Purpose:

To determine whether an increased tibiofemoral rotation angle is associated with graft failure after primary medial patellofemoral ligament reconstruction (MPFL-R) and to investigate the role of the tibiofemoral rotation angle in predicting MPFL-R failure in patients with RPDs.

Study Design:

Case-control study; Level of evidence, 3.

Methods:

We retrospectively analyzed the records of 632 consecutive patients with clinically diagnosed RPDs from 2011 to 2018. Postoperative stress radiography of the patellofemoral joint was performed to identify whether the graft failed. After a review, 33 patients who showed MPFL-R failure were allocated to the failure group. They were matched 1:2 to 66 participants who underwent successful MPFL-R (control group). The cutoff value and area under the curve (AUC) of the tibiofemoral rotation angle for predicting graft failure after primary MPFL-R were determined, and the risk factors for MPFL-R failure were assessed by multivariate logistic regression analysis.

Results:

The tibiofemoral rotation angle was significantly higher in the failure group than in the control group (16.4° ± 5.6° vs 6.4° ± 4.5°, respectively; P < .001). The cutoff value of the tibiofemoral rotation angle for predicting graft failure was 12.3° (sensitivity, 81.8%; specificity, 89.4%; AUC, 0.920). Overall, 3 risk factors for MPFL-R failure were determined: excessive tibiofemoral rotation (≥12.3°) (odds ratio [OR], 13.159 [95% CI, 2.469-70.139]; P = .003), a preoperative high-grade J-sign (OR, 7.674 [95% CI, 1.232-47.809]; P = .029), and a femoral tunnel malposition (OR, 6.976 [95% CI, 1.077-45.187]; P = .042).

Conclusion:

In this study, excessive tibiofemoral rotation, a preoperative high-grade J-sign, and a femoral tunnel malposition were identified as risk factors for graft failure after primary MPFL-R in patients with RPDs. More importantly, excessive tibiofemoral rotation ( ≥ 12.3°) may predict the failure of primary MPFL-R, which can help surgeons easily identify high-risk patients of MPFL-R failure before surgery.
Self-reported Impact of the Early 2020 COVID-19 Crisis on the Healthcare Pathway During and After Lockdown in Patients With Chronic Immune-Mediated Inflammatory Diseases: A Practical Survey
Authors: Nasseh Jessica , Podevin Céline , Ternynck Camille , Zephir Hélène , Letarouilly Jean-Guillaume , Flipo René-Marc , Nachury Maria , Chenivesse Cécile , Hachulla Eric , Launay David , Staumont-Salle Delphine , Dezoteux Frédéric
Published: December 2022

Introduction: Global lockdown in the context of the coronavirus disease 2019 (COVID-19) pandemic is an unprecedented experience. We report here the results of an anonymous questionnaire-based survey on the healthcare and control of chronic IMIDs (chronic immune-mediated inflammatory diseases) within the IMMINENT network during the French lockdown (March 17, 2020-May 11, 2020) and the 2-month period following the end of the lockdown (July 11, 2020). Methods: Two anonymous questionnaires were sent by email to 4500 patients who were followed in a university hospital for an IMID in the departments of gastroenterology, rheumatology, dermatology, pneumology, neurology, and internal medicine. Results: A total of 921/4500 (20.46%) responded to the first survey (impact of the lockdown), and 553/4500 (12.28%) to the second (impact at 2-months post-lockdown). Concerning the impact of the lockdown, 420/915 (45.9%) reported affected follow-up. Similarly, after the lockdown, 248/544 (45.6%) declared a negative impact on their follow-up. The repartition by departments of patients’ perception of an altered follow-up during ( P = .72) and at the end of the lockdown ( P = .77) was not statistically different. Our study highlighted the effects of the COVID-19 pandemic and the restriction measures implemented on the self-reported impact felt by patients on the follow-up of their chronic IMIDs without significant differences among all departments. Conclusion: Our study is original by showing that patients, whatever the type of IMID, shared this same negative perception. This transdisciplinary study demonstrated the importance of a collaborative network among all departments.
‘Mainstreaming’ Meets ‘Choice and Control’: Unsettling Neoliberal Imaginaries of Service Choice
Authors: Wiesel Ilan , Bigby Christine , van Holstein Ellen , Gleeson Brendan
Published: December 2022

‘Mainstreaming’ and ‘Choice and control’ agendas have played a dominant role in shaping disability policy and advocacy in many countries since the 1970s, however scholarship is yet to critically explore the tensions and synergies between the two. ‘Mainstreaming’ is the aspiration to move people with disability out of ‘specialist’ spaces designed specifically for them, and into ‘mainstream’ spaces open to people of all abilities. ‘Choice and control’ concerns efforts to enhance autonomy and self-determination for people with disability. In this paper we interrogate the relationship between ‘choice and control’ and ‘mainstreaming’, both conceptually and through empirical examination of choices made by people with intellectual disability about use of mainstream services in four Australian cities. Our analysis shows their ability to choose is severely constrained by excessive control practiced by supporters, funding restrictions, affordability constraints, and exclusionary practices in mainstream services. We argue that the potential for both ‘choice and control’ and ‘mainstreaming’ has been constrained by neoliberal socio-spatial imaginaries in which they have been framed.
Achieving MRD negativity in AML: how important is this and how do we get there?
Authors: Hourigan Christopher S.
Published: December 2022

Multiple studies have demonstrated that patients with acute myeloid leukemia (AML) who have measurable residual disease (MRD) detected during or after treatment have higher relapse rates and worse survival than similar patients testing negative. Updated response criteria for AML reflect the understanding that achievement of complete remission (CR) with no detectable MRD using high-sensitivity tests represents a superior response over conventional cytomorphological CR alone. Potential use cases for AML MRD testing are diverse and include patient selection for clinical trials and therapeutic assignment, early relapse detection and intervention during sequential monitoring, and drug development, including deep quantification for antileukemia efficacy and as a surrogate endpoint for overall survival in regulatory approvals. Testing for AML MRD has not, however, been harmonized, and many technical and clinical questions remain. The implications of MRD test results for specific therapeutic combinations, molecular subsets, test types, treatment time points, sample types, and patient characteristics remain incompletely defined. No perfect AML MRD test or testing strategy currently exists, and the evidence basis for clinical recommendations in this rare disease is sparse but growing. It is unproven whether conversion of an MRD test result from positive to negative by additional therapeutic intervention improves relapse risk and survival. Several national- and international-level consortia have recently been initiated to advance the generation and collection of evidence to support the use of AML MRD testing in clinical practice, drug development, and regulatory approvals.
Transplantation in CML in the TKI era: who, when, and how?
Authors: Niederwieser Christian , Kröger Nicolaus
Published: December 2022

Molecular therapy with tyrosine kinase inhibitors (TKIs) has significantly reduced the indication for allogeneic hematopoietic stem cell transplantation (allo-HSCT) in chronic myeloid leukemia (CML). Treatment-free remission can be obtained in about 50% of patients with an optimal response. However, cure rates up to 90% are restricted to patients receiving HSCT. Timing is essential since HSCT in the early stages of the disease has the best outcome. Patients in a more advanced phase (AdP) than chronic-phase (chP) CML undergo HSCT with suboptimal outcomes, and the gap between chP and AdP disease is widening. First-line therapy should start with first- or second-generation (G) TKIs. Patients failing treatment (BCR-ABL1 transcripts of greater than 10% at 3 and 6 months and greater than 1% at 12 months) should be switched to second-line TKIs, and HSCT should be considered. Patients not responding to 2G-TKI therapy as well as patients in an accelerated phase (AP) or blast crisis (BC) are candidates for HSCT. Therapy resistant BCR-ABL1 mutations, high-risk additional cytogenetic abnormalities, and molecular signs of leukemia progression should trigger the indication for HSCT. Patients who, despite dose adjustments, do not tolerate or develop severe adverse events, including vascular events, to multiple TKIs are also candidates for HSCT. In AdP CML, TKIs do not show long-lasting results, and the outcome of HSCT is less optimal without pretransplant therapy. In these patients the induction of chP2 with TKIs, either alone (AP) or in combination with intensive chemotherapy (BC), followed by HSCT should be pursued.
New developments in ALL in AYA
Authors: Boissel Nicolas
Published: December 2022

The outcome for adolescents and young adults (AYA) with acute lymphoblastic leukemia (ALL) has improved, mostly based on the use of pediatric-inspired intensive protocols. Due to increasing disease resistance and treatment-related toxicity with age, further improvements are now expected from the expanding knowledge of ALL biology, more accurate risk stratification, and the early introduction of targeted small molecules and immunotherapy. In the last decade, the rate of AYA with B-cell precursor ALL with undetermined genetic drivers (“B-other”) has shrunk from 40% to fewer than 10%. The high-risk subgroup of Philadelphia-like ALL is the most frequent entity diagnosed in this age range, offering a multitude of potentially actionable targets. The timely and accurate identification of these targets remains challenging, however. Early minimal residual disease (MRD) monitoring has become a standard of care for the risk stratification and identification of patients likely to benefit from an allogeneic hematopoietic stem cell transplantation. Recently approved immunotherapies are moving frontline to eradicate MRD, to improve the outcome of high-risk patients, and, eventually, to reduce treatment burden. Comprehensive care programs dedicated to AYA with cancer aim at improving inclusion in specific clinical trials and at giving access to appropriate psychosocial support, fertility preservation, and survivorship programs.