bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic Significance of Mutations in DNMT3A in Patients with Myelodysplastic Syndrome: a Meta-Analysis
Authors: П.В. Липилкин, , Е.Д. Кулаева, , Е.С. Музлаева, , Е.В. Машкина, , Ю.В. Шатохин,
Published: December 2022

Цель. Мутации в гене DNMT3A исследуются на предмет прогностической значимости при МДС, но связь между этими мутациями и прогнозом для пациентов остается неясной. Поэтому мы провели метаанализ для оценки влияния мутаций DNMT3A у пациентов с МДС с целью определения их прогностической значимости. Материалы и методы. Были отобраны 12 исследований путем поиска в базах данных PubMed, Embase, Web of Science, ClinicalTrials и Cochrane Library. Для оценки влияния мутаций DNMT3A на прогноз у пациентов с МДС были исследованы отношения рисков (ОР/HR) и их 95%-ные доверительные интервалы (ДИ/CI) для общей выживаемости (ОВ/OS). Результаты. В метаанализ было включено 12 исследований с общей выборкой 2169 пациентов. Объединенные ОР для ОВ показали, что для пациентов с МДС с мутациями DNMT3A прогноз был значительно хуже, чем для пациентов без мутаций (ОВ: ОР=1,64, 95% ДИ 1,37–1,97, p<0,00001). Для пациентов из США была выявлена тенденция взаимосвязи их региона и влияния мутаций в гене DNMT3A на ОВ, что может быть следствием особенностей национального регистра онкологических заболеваний и доступа к участию в клинических испытаниях и широких молекулярно-генетических исследованиях.

Purpose. Mutations in DNMT3A are being investigated for prognostic value in MDS, but the relationship between these mutations and prognosis for patients with AML remains unclear. Therefore, we are conducting a meta-analysis to estimate the effect of mutations in MDS to determine their prognostic significance. Materials and methods. Twelve studies were selected by searching PubMed, Embase, Web of Science, ClinicalTrials, and the Cochrane Library databases. Hazard ratios (HRs) and their 95% confidence intervals (CIs) for overall survival (OS) were pooled to assess the effect of DNMT3A mutations on the prognosis in MDS patients. Results. A total of 12 studies with 1974 patients were included in this meta-analysis. The pooled HRs for OS revealed that MDS patients with DNMT3A mutations had a significantly poor prognosis as compared with those without mutations (OS: HR = 1.64, 95% CI 1.37– 1.97, p<0.00001). Mutations in DNMT3A showed strong relationship with male/female ratio, but showed no relationship with study region, IPSS and IPSS-R classifications. Mutations in DNMT3A showed a trend-level relationship with patients from the United States of America, which may be a consequence of features of the national cancer registry and access to participation in clinical trials and broad molecular genetic studies.
Personalized Immunotherapy in the Treatment of Patients with Malignant Gliomas
Authors: М.Ю. Рыков, , И.С. Долгополов, , Г.З. Чкадуа,
Published: December 2022

Цель. Повышение выживаемости пациентов с глиомами. Материалы и методы. В исследование включены 5 пациентов в возрасте от 2 до 16 лет (средний возраст – 7,6 года). У трех пациентов диагностирована анапластическая астроцитома (AA), у одного пациента – мультиформная глиобластома (МГ) (3-й рецидив) и еще у одного пациента – диффузная глиома ствола мозга (ДГ). Среднее время до развития первого рецидива составило 12 месяцев (от 4 до 16 мес.), до развития второго – 5 месяцев (от 1 до 8 мес.). Протокол иммунотерапии включал комбинированное введение аутологичной вакцины на основе дендритных клеток (ДВ) и повторные интратекальные/внутрижелудочковые инъекции донорских аллогенных иммунокомпетентных клеток в течение не менее 2 лет. Результаты. У двух из трех пациентов с АА интервал без прогрессирования составил 67 и 71 месяц. Один пациент с третьим рецидивом МГ жив без какой-либо терапии через 13,3 года после начала иммунотерапии. Среднее время наблюдения составило 67 месяцев, общая двухлетняя выживаемость составила 58%. Два пациента умерли от прогрессирования заболевания в течение 6 и 7 месяцев от начала иммунотерапии. За период лечения пациенты получали в среднем 20 (от 8 до 60) инъекций аллогенных иммунокомпетентных клеток и 18 (от 8 до 44) инъекций ДВ. Побочных эффектов не наблюдалось. Заключение. Иммунотерапия может быть привлекательным вариантом для лечения пациентов со злокачественными глиомами высокой степени злокачественности, не поддающимися традиционной терапии, и заслуживает дальнейшего изучения.

Purpose. Improving the survival rate of patients with gliomas. Materials and methods. Our study included 5 patients, median age 7.6 years (2–16). Three pts had anaplastic astrocytoma (AA) (1st recurrence – 1 pt, 2nd recurrence – 2 pts), 1 pt had glioblastoma multiforme (GBM) (3rd recurrence) and 1 pt had diffuse brainstem glioma (BSG). The median time to the first relapse was 12 months (4 to 16), to the second one – 5 months (1 to 8). The protocol of immunotherapy included combined administration of autologous dendritic cell-based vaccine (DV) and repeated intrathecal/intraventricular injections of donor allogenic immunocompetent cells (alloIC) for at least 2 years. Results. Two of 3 pts with AA experienced a progression-free interval of 67 and 71 months One pt. with 3rd GBM relapse is alive without any therapy 13.3 years after immunotherapy start. The median time of follow-up was 67 months with the 2-years overall survival was 58%. Two pts died from disease progression within 6 and 7 months from the start of immunotherapy. Over the period of treatment the pts received a median of 20 (8 to 60) alloIC injections and 18 (8 to 44) DV administrations. No serious side-effect was observed. Conclusion. Immunotherapy could be an attractive option for treating patients with high-grade malignant gliomas irresponsible to conventional therapy and is worthy of further investigation.
Information Content Detection in Face Parts Using Deep Learning
Authors: Dobeš Marek , Sabolová Natália
Published: December 2022

The present paper introduces use of deep neural network for classification of three different categories of emotions - angry, happy and neutral. The database consisted of 48x48 pixel grayscale images of faces from the Face expression recognition dataset from Kaggle. Separate parts of faces such as eyes, nose, or mouths were occluded by a manually inserted 48x15 pixel black rectangle to see what part of the face carries the most significant information about the expressed emotions. By applying pretrained Inception network provided as a part of Keras/Tensorflow environment, we found that, to our surprise, faces with eyes covered were more easily identified. Results were replicated using augmented data.
Verification of Selected Model Coefficients for a Small Unmanned Aircraft
Authors: Hlinková Miriam , Andoga Rudolf , Karaffa Šimon
Published: December 2022

This article presents design and analysis of mathematical model UAV with fixed wings. The mathematical model serves to understand the basic mathematical principle and physical laws, that are applied to the system, and is indispensable in UAV movement simulation and modelling of the control algorithms. The article also describes the methodology of individual modelled parts using the XFLR5, where effective numerical methods are used for mathematical modelling. The last part provides verified and reliable results obtained by simulations of a mathematical model, which will be used to simulate basic and critical situation states.
Concept of the Mobile Monitoring System
Authors: Dolný Eduard , Moravčíková Alena
Published: December 2022

In connection with the spread of viral diseases caused by COVID-19, its high dynamics and the formation of infection outbreaks were observed. The experience from the first wave of the pandemic showed that, although state-wide measures are effective, they have a significant economic impact and more effective solutions are therefore necessary. In the activities aimed at combating the pandemic caused by COVID-19, one of the most effective means is the isolation of sick patients and the most vulnerable population groups, where the level of risk is the highest. No universally applicable technical solutions which are available on the commercial market would assist in population isolation, in case of protection and monitoring. Creating a mobile monitoring system to protect isolated and at-risk population groups against the spread of viral diseases is highly relevant within Slovakia and with great potential for applicability abroad. This article is focused on the project description that was approved in connection with the protection against the spread of COVID-19, the definition of its main goals, methodology, activities, and benefits.
Fatiha Suresi Dil ve Belagat İncelemesi
Authors: AYDIN Atik
Published: December 2022

Fatiha suresi, Kur’an’ın mukaddimesi ve özeti olduğu gibi namazın da vaz geçilmez bir parçasıdır. Din ve ibadet açısından önemli olduğu kadar dil ve belagat açısından da son derece önemli bir metindir. Kur’an ve sünnette Fatiha suresinin önem ve faziletinden vurgulu bir şekilde söz edilmiş olması, bunun bir tezahürüdür. Bu önemin başka bir tezahürü ise diğer surelerden farklı olarak Fatiha suresinin pek çok isminin olmasıdır. Namazda huşunun sağlanabilmesi ve Kul-Rab arasında sahici bir buluşmanın gerçekleşmesi için okunan sure, dua ve zikirlerin ne anlama geldiği bilinmesi gerekir. İşte bu çalışmada Fatiha suresinin dil ve belagat inceliklerini ortaya koymaya ve bu inceliklerin kulluk ve namaz ile olan irtibatını el aldık. Çalışmamızda her türden tefsir kitaplarına başvursak da el-Keşşâf ve et-Tâhrîr ve’t-Tenvîr gibi dil ve belagat yönü öne çıkan tefsirler birinci dereceden referans kayanğımız oldu. Bu kay-naklardaki Fatiha suresi ile ilgili dilsel incelikleri ihtilaflı boyutlara girmeden yansıtmaya çalıştık.
REFLEXÕES SOBRE O ASPECTO FORMAL DA EMENDA CONSTITUCIONAL Nº 106/2020 “ORÇAMENTO DE GUERRA
Authors: DE CASTRO DOURADO CORDEIRO WESLEY
Published: December 2022

The purpose of this article is to study the formal aspect of the Constitutional Amendment n. 106/2020 not analyzed by STF. Among the measures to fight Covid-19 Pandemic, the Constitutional Amendment n. 106/2020 was proclaimed. Through this rule, an extraordinary fiscal, financial and contracting regime was authorized. The normative species that was conveyed presents an intriguing feature: it is a constitutional amendment that does not amend anything. The Constitutional Amendment n. 106/2020 does not amend the Constitution itself, nor the Transitory Constitutional Provisions Act, and it acts as autonomous legislation. From this perspective and based on the doctrine of constitutional law, the text raises some hypotheses for such an option, generally and specifically, finally suggesting hypotheses of unconstitutionality, such as the abuse of Legislative Power.
Experimentalismo democrático, crecimiento y educación
Authors: Mattarollo Livio
Published: December 2022

En el campo de la epistemología política, un problema clave es cómo balancear los compromisos epistémicos para tomar decisiones políticas adecuadas con los compromisos morales sustantivos. El presente artículo se propone abordar este problema desde el enfoque del pragmatista clásico John Dewey, habida cuenta de que en su pensamiento es posible identificar un argumento epistémico y un argumento formativo en favor de la democracia. Para ello, en primer lugar se reconstruye el argumento epistémico y se analizan las críticas respecto de su presunto carácter instrumental. En segundo lugar, se reconstruyen las líneas centrales del argumento formativo y se consideran tanto las condiciones para el cumplimiento del ideal moral de crecimiento como el carácter educativo de la democracia. Desde aquí se sostiene (i) que la fundamentación epistémica y la fundamentación “sustantiva” son convergentes y que la noción de crecimiento hace las veces de pivote entre ambos; y (ii) que la educación en general y la educación formal en particular fungen como ámbito de la convergencia entre ambas justificaciones de la democracia. Esto se presenta como un elemento de enorme potencial práctico para la epistemología política y permite enfatizar –una vez más– la centralidad de la educación en el proyecto filosófico-político de Dewey.
Explicación funcional y análisis sistémico
Authors: Barberis Sergio Daniel , Ginnobili Santiago , Roffé Ariel
Published: December 2022

En este artículo sostenemos que, en aquellos casos en los cuales la capacidad explanandum de un análisis sistémico o mecanicista constituye una función biológica, globalmente, la función explica la estructura y no a la inversa, a pesar de que en algunos casos particulares, el orden en que se determinan los conceptos participantes en la explicación no coincide con el orden de la explicación. Para defender esta tesis, adoptaremos una concepción mínima de explicación basada en la idea de subsunción ampliativa del estructuralismo e ilustraremos las diferencias entre el orden de la explicación y el orden de determinación de los conceptos mediante un estudio de caso tomado de la afasiología moderna.
La cristalización de la biología molecular
Authors: Federico Lucía , Navarro Cristina
Published: December 2022

El presente trabajo busca llevar a cabo una reconstrucción racional de un suceso histórico, tal como lo fue el surgimiento de la biología molecular, visto a la luz de la filosofía de Thomas Kuhn. Pese a que varios autores señalaron la inadecuación de la propuesta metateórica de La Estructura (aún con los remiendos de la Posdata del 69) postulamos que es factible una reconstrucción del origen de esta (sub)disciplina bajo la categorías de paradigma-matriz disciplinar y ciencia normal con algunos refinamientos. Pretendemos mostrar el surgimiento de un nuevo paradigma como la convergencia de dos líneas de investigación, una sobre la forma de la molécula de la vida, la otra sobre su función hereditaria.
La curiosidad mató al gato
Authors: Piacenza Cecilia
Published: December 2022

Los múltiples cuestionamientos en torno a la figura del hombre propugnada por el humanismo trajeron aparejada la pregunta por la cuestión animal ¿Hasta qué punto es posible contraponer a los animales a la figura del hombre? ¿Por qué nos resulta tan difícil desprendernos de nuestras viejas concepciones a pesar de la perseverancia de los movimientos antiespecistas? En este ensayo me propongo examinar los presupuestos que, desde el humanismo, mantuvieron alejado al hombre de su entorno y la forma en la que las nuevas perspectivas nos permiten flexibilizar los márgenes que delimitan lo humano y lo no-humano. Especialmente, me interesaría ahondar en torno a la posibilidad de repensar la forma en la que tradicionalmente se definió a la categoría animal y cómo dicha definición afecta enormemente nuestra autopercepción, buscando una complejización y apertura a nuevas modos de entender la subjetividad.
Presentación
Authors: Fierro María Angélica , Sain Abril Sofia
Published: December 2022

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Investigation of Cold Recycling of Bituminous Surface Treatment with Foam Bitumen
Authors: ERTEN Kemal Muhammet , TERZİ Serdal , AKBULUT Hüseyin
Published: December 2022

The course of turned of bituminous pavement layers into hot mix asphalt (HMA) layers has been increasing day by day all over the world. Bituminous surface treatment that contains consirable amount of aggregate and bitumen, is an important source of recycling that offers a great amount of pavement materials intead of virgin material usage on pavement consruction.
In the study, it was aimed to investigate the usability of bituminous surface layer treatment in the base layers of the HMA roads by mixing with foam bitumen and active filler materials in order to eliminate the potential performance degradation that will be encountered when it is recycled due to the low bitumen percentage compared to hot mix asphalt and the wear of the aggregate due to climatic conditions and traffic loads over time.
The study conducted that intends to technically evaluate the cold recycling of bituminous surface treatment of roads with foam bitumen and active filler materials; for 70/100 bitumen grade, 5 different bitumen mixes were prepared and ideal bitumen percentage was investigated for this bitumen grade. The effect of bitumen percentage on mixture performance was evaluated with 50/70-100/150-160/220 bitumen grades and mixtures were prepared in single bitumen ratio (2.5%). It was investigated that active fillers will give suitable results for foam bituminous mixtures by preparing mixtures for three different active fillers; cement, hydrated lime and fly ash. To evaluate all these productions, ITS, unconfined compressive strenght, triaxial resilient modulus and asphalt permanent deformation tests were performed.
The results obtained showed that production made using 2% foam bitumen and 1% was found suitable for moisture sensitivity and structural stability. Recycling of bituminous surface treatment using foam bitumen and cement is an environmentally and economically beneficial method by reducing both waste and raw material consumption.
ANFİS Model ile Mg Alaşımlarının Sıkıştırılabilirliğinin Tahminleme Performasının İncelenmesi
Authors: ZALAOĞLU Demet , KARAKUS Pinar
Published: December 2022

Bu çalışmada, farklı Zn (ağırlıkça %5 ve 10 Zn) oranlarına sahip Mg alaşımlarına ait toz karışımları hazırlanmış ve farklı sıkıştırma basınçlarında sıkıştırılarak hesaplanan ham yoğunluklar ile ANFİS model için test ve eğitim verileri elde edilmiştir. Elde edilen test ve eğitim verileri, Matlab programında ANFİS ile eğitilmiş ve sonuçlar incelenmiştir. Yapılan eğitimlerde, ANFİS model de giriş üyelik fonksiyon tipi olarak trimf, üyelik fonksiyonu sayıları olarak ise 2 2, 3 3, 4 4, 5 5 kullanılmış, çıkış üyelik fonksiyonu constant olarak seçilmiştir. MAPE, MSE, RMSE göre seçilen üyelik fonksiyonlarının tahminleme performansları karşılaştırılmıştır. Elde edilene sonuçlar, ANFİS modelinin Mg-Zn toz karışımlarının sıkıştırılabilirliğinde kullanılabilirliğini göstermiştir.
Koagülaz Negatif Stafilokok Vajen İzolatlarının Antibiyotik Duyarlılıkları
Authors: ER Sevda
Published: December 2022

Koagülaz negatif stafilokoklar insan deri ve mukoz membranların florasında yer alan fırsatçı patojenlerdir. Hastane enfeksiyonlarının önemli etkenleri arasındadır. Çalışmada koagülaz negatif Staphylococcus vajen izolatları kullanılmıştır. İzolatlar, aerobik koşullarda, 37 °C ’de 24 saat inkübasyona bırakılmıştır. Duyarlılık tespiti için disk difüzyon yöntemi kullanılmıştır. Besiyerinde 37 °C ’de 24 saat geliştirilmiş olan Staphylococcus izolatları Mc Farland 0,5 (108 kob/mL) şeklinde ayarlanmış besiyerine ekilmiştir. Çalışmada, trimetoprim + sülfametoksazol, gentamisin, eritromisin, sefoksitin, siprofloksasin, penisilin G, klindamisin ve linezolid antibiyotikleri incelenmiştir. İzolatların en az penisilin G’ye en fazla ise trimetoprim + sülfametoksazole duyarlılık gösterdiği bulunmuştur. İzolatlardan tamamı trimetoprim + sülfametoksazole duyarlıdır. Sadece iki izolatın penisilin G’ye duyarlı olduğu belirlenmiştir. Bunların dışında 26 izolatın linezolide, 23 izolatın siprofloksasine, 22 izolatın gentamisine ve 21 izolatın eritromisine duyarlı oldukları tespit edilmiştir. Literatürde özellikle vajen Koagülaz negatif stafilokok izolatlarının antibiyotik duyarlılıkları üzerine çok fazla çalışma yer almamaktadır. Ülkemizde de bu konuda bir çalışmaya rastlanılmamıştır. Bu sebeple, yapılan çalışma literatüre katkı sağlayacaktır.
GHSR rs2232165 Gen Polimorfizminin Genotiplendirilmesi için PCR-RFLP Yönteminin Optimizasyonu ve Türk Erkeklerinde Alel Frekansının Belirlenmesi
Authors: ÖZKAN KOTİLOĞLU Selin , KAYA AKYÜZLÜ Dilek , DÜZGÜN Gizem , DANIŞMAN Mustafa , AĞTAŞ ERTAN Ece , ÖZGÜR İLHAN İnci
Published: December 2022

Çağımızın ciddi sorunlardan biri olan alkol bağımlılığı, genetik, çevresel, kültürel, gelişimsel ve nörobiyolojik faktörlerin etkisiyle ortaya çıkmaktadır. Son yıllarda yeme davranışı nörobiyolojisi ile bağımlılık yapan maddelere aşerme davranışının nörobiyolojisinin benzer özelliklere sahip olduğunun keşfedilmesi araştırmacıları, alkol bağımlılığı ile grelin gibi besin alımında önemli olan hormonlar arasındaki ilişkiyi araştırmaya sevk etmiştir. Alkol kullanım bozukluğunda ve alkole aşermede grelin sisteminin önemi mevcut çalışmalar tarafından ortaya konulmasına karşın bu ilişkinin biyolojik mekanizmasının aydınlatılması için daha çok çalışmaya ihtiyaç vardır. Bu nedenle, bu çalışmada, alkol kullanım sorunu olan Türk erkeklerinde, grelin reseptörünü kodlayan GHSR genindeki rs2232165 polimorfizminin alkol kullanım sorunu ile ilişkisi araştırılmıştır. Çalışmaya alkol kullanım bozukluğu tanısı konmuş 72 erkek birey ile herhangi bir madde bağımlılığı olmayan 82 sağlıklı erkek dahil edilmiştir. GHSR rs2232165 gen polimorfizmi, ilk defa bu çalışmada optimize edilen PCR-RFLP yöntemi ile genotiplendirilmiştir. GHSR rs2232165 polimorfizmi için alel frekansları alkol kullanım sorunu olan grupta (n:144); C aleli için 0,99 (n:142), T aleli için 0,01 (n:2) olarak hesaplanmıştır. Karşılaştırma grubunda ise (n:164), C aleli frekansı 0,98 (n:161), T aleli frekansı 0,02 (n:3) olarak belirlenmiştir. İki grup arasında, T alel frekansı açısından istatistiksel olarak anlamlı bir fark bulunmamıştır (p>0,05). Gen polimorfizmleri, çevresel faktörlerden etkilenmediği için Türk erkeklerindeki minör alel frekansını (MAF) belirlemek için iki gruptaki bireyler birleştirilmiş (n=154) ve Türk erkeklerinde GHSR rs2232165 polimorfizminin MAF değeri 0,02 olarak belirlenmiştir. Bu çalışmada, çağımızda alkol kullanım bozukluğu kadar önemli olan obezite etiyolojisinde de rol oynayan GHSR rs2232165 polimorfizminin Türk erkeklerinde alel frekansı ile ilgili ilk veriler toplanmıştır.
Effect of the Al Doping on the Sensing Behaviour of Carbon Nanotubes Toward Carbazochrome: a Computational Study
Authors: GENÇ Fatma , KANDEMİRLİ Fatma
Published: December 2022

In the current report, the interaction of Al-doped carbon nanotubes (CNT) with carbazochrome, an anti-hemorrhagic or hemostatic agent, was investigated with the M06-2X functional and 6-31G* basis set. The global index including frontier molecular orbital energies, hardness, softness, chemical Gibbs energies and some parameters and NLO properties of Carbazochrome, Al doped CNT and complexes formed between their were calculated and evaluated. Electron localization function (ELF) calculations were performed to validate the essence of the formed bonding model progress along the interaction. It is obtained that polarizability of the complex are bigger than those of Carbazochrome and Al doped CNT. According to the maximum electron flow index, the electrophilicity power is increased by increasing the chemical potential, the decreasing chemical hardness. All obtained complexes are exergonic and thus thermodynamically favorable
T/M Yöntemi ile Üretilen Al-15Zn Alaşımının Sinterleme Sonrası Isıl İşlem Süreçlerinin İncelenmesi
Authors: AVCI Uğur
Published: December 2022

Bu çalışmada, hafif metaller grubunun bir üyesi olan Al-Zn alaşımı toz metalürjisi yöntemi ile üretilmiş olup, sinterleme uygulaması sonrasında çözeltiye alma ve yaşlandırma ısıl işlemleri tatbik edilerek mikro yapı ve mekanik özelliklerindeki değişimler incelenmiştir. Çalışmada %99 saflıkta 44 µm boyutundaki Al tozları ile ağırlıkça %15 oranında aynı özelliklere sahip Zn tozları mekanik olarak karıştırılmıştır. Bu işlem sonrasında elde edilen homojen dağılımlı toz karışımı sıkıştırılarak ham şekillendirilmiş numune haline getirilmiştir. Elde edilen numunelerin boyutsal değişiminin kontrol altına alınabilmesi için, sinterleme işlemi kalıp içerisinde yapılmıştır. Sinterleme kalıbına yerleştirilen ham numuneler 600 oC sıcaklıkta 45 dakika sinterlenmiş ve sonrasında kalıp içerisinde sıkıştırılarak havada soğutulmuştur. Üretim süreci tamamlandıktan sonra çözeltiye alma, su verme ve yaşlandırma işlemi olarak üç ana başlık altında gerçekleştirilen ısıl işlem sürecine geçilmiştir. Çözeltiye alma işlemi için, üretilen numuneler ayrı ayrı 470, 480 ve 490 oC sıcaklıklarda 90 dk. tavlama fırınında tutulmuştur. Bu işlem sonrasında fırından çıkartılan numuneler hiç bekletilmeden oda sıcaklığındaki suya daldırılarak su verme işlemi gerçekleştirilmiştir. Ani soğutma işlemine maruz kalan numuneler 100 oC sıcaklıkta 2880 dk. bekletilerek ısıl işlemin son aşaması olan suni yaşlandırma süreci tamamlanmıştır. Yapılan ısıl işlemler sonunda numunelerin tane boyutu mikro sertlik ve aşınma özelliklerindeki değişimler incelenmiştir. İncelemelerde 480 oC sıcaklıkta çözeltiye alınan numunenin yaşlanma süreci sonrası sertlik ve aşınma dayanımının diğer numunelere göre yüksek, tane boyutunun ise düşük olduğu belirlenmiştir.
Yerinde Erken Yaş Beton Dayanımını Belirlemek İçin Kombine Metotların Geliştirilmesi
Authors: TAŞ Yavuzhan , ULUCAN Muhammed , ALYAMAÇ Kürşat Esat
Published: December 2022

Bu çalışma, yerinde erken yaş beton dayanımını yüksek doğrulukla tespit etmek için kombine metotlar geliştirmek ve geliştirilen modelleri uygulama yapısı üzerinde test edilmesini amaçlamaktadır. Bu amaçla, Elazığ-Malatya İlleri arasında 2016-2020 yılları arasında inşa edilen Yeni Kömürhan Köprüsünün pilon betonlarından, tahribatsız test metodu ölçümleri ve beton numuneler alınmıştır. Elde edilen ölçüm ve numunelerin test sonuçları kullanılarak tepki yüzeyi metodu (RSM) yardımıyla matematiksel modeller geliştirilmiştir. Geliştirilen matematiksel modeller esas alınarak tahribatsız test metotlarının ikili kullanımlarıyla üç farklı kombine metot geliştirilmiştir. Yapılan bu çalışma sonucunda, geliştirilen kombine metotlar, kömürhan köprüsü pilon betonlarının yerinde erken yaş beton dayanımını test etmek için kullanılmıştır. Pilonların 3 ve 7 günlük basınç dayanımları, geliştirilen kombine metotlarla tahmin edilmiştir. Bu tahminler sonucunda, ikili kombine metotların iyi sonuçlar verdiği görülmüştür. Geliştirilen kombine metotlar, Kömürhan köprüsü gibi büyük ve prestijli bir yapıda test edilmiş, yerinde erken yaş beton dayanımını yüksek doğrulukla tahmin ettikleri görülmüştür. Böylece, kombine metotların büyük ve prestijli yapılarda kullanımının önemli miktarda maliyet kazancı, kalıp alma süresinden kaynaklı zaman tasarrufu ve iş gücü kazancı sağlayacağı düşünülmektedir
Biyokompozit membran ile yağlı atık suların saflaştırılması
Authors: UĞUR NİGİZ Filiz
Published: December 2022

Bu çalışmada, biyobozunur polilaktik asit polimerinin yağ-su ayırımındaki performansı incelenmiştir. Çalışma kapsamında membranlar hazırlanmış ve vakum filtrasyon işlemi uygulanmıştır. Membranın yağ ve suya olan ilgisi, yağ ve su içindeki şişme testleriyle belirlenmiştir. Membranın hidrofilitesini arttırmak ve performansını iyileştirmek için içine halosit nanotüp (HNT) eklenmiş ve nanokompozit haline getirilmiştir. Membranın yüzey morfolojisi taramalı elektron mikroskobuyla (SEM) ile belirlenmiştir. Çalışmada halosit nanotüp oranının (%0-20), yağ/su şişme oranlarına (adsorpsiyon oranına), membrandan geçen sıvı akısına ve yağ reddine etkisi belirlenmiştir. Çalışmada model yağ olarak soya yağı seçilmiştir. Soya yağı-su emülsiyonu hazırlanarak ayırım testleri yapılmıştır. Elde edilen sonuçlara göre soya yağı ayırımında %5 HNT katkısında %97.2 saflıkta su alt akımdan elde edilmiştir. Yüksek ayırımın yanında 1714.3 üzerinde saatte litre bazında su akısı elde edilmiştir.
Zergatik panpox: flâneusearen arrastoan
Authors: Majuelo Itoiz Irati
Published: December 2022

Artikulu honek Zergatik panpox (1979) eleberrian espazioak dituen funtzio eta esanahiak aztertu ditu kritika feministaren ikuspuntutik. Euskal eleberrigintza urbanoaren hastapenetan, Urretabizkaiaren lehen nobelako emakumezko protagonistak hiria nola bizi duen analizatu da. Oinarri teoriko modura hartu dira espazio publikoaren eta pribatuaren bereizketa zalantzan jartzen duten teoriak, baita literatura urbano hegemonikoaren figura nagusiei buruzko ideiak ere. Hala, nobelan adierazten diren espazioak eta protagonistaren joan-etorriak elkarrizketan jarri dira flâneuraren zein flâneusearen teoriekin, eta ondorioztatu flâneusearen zantzuak aurki daitezkeela protagonistarengan.
Taxonomic and nomenclatural novelties in Syntrichia (Bryophyta: Pottiaceae), with reinstatement of an endemic continental Antarctic species
Authors: Ochyra Ryszard , Saługa Marta , Ronikier Michał
Published: December 2022

Taxonomic implications of the phylogeographic studies based on multilocus sequencing of nuclear and chloroplast DNA regions of Syntrichia sarconeurum, long considered to be Antarctic endemic moss species, are summarised. Molecular analyses confirmed the conspecificity of Syntrichia sarconeurum with S. lithophila and S. pygmaea. This taxonomic conclusion implies that the correct name for the species in the genus Syntrichia is S. lithophila and S. sarconeurum is a new synonym of this name. It is because S. sarconeurum takes priority from 2007, whereas S. lithophila is based on Tortula lithophila which was validly published in 1906 and it is the next earliest legitimate name at the rank of species to be used. Syntrichia sarconeurum, as traditionally conceived, proved to be a heterogeneous taxon actually consisting of two distinct species, namely S. lithophila and S. frigorideserticola nom. nov., which is a new name for Sarconeurum antarcticum whose epithet is not available in Syntrichia. Australian and New Zealand plants of Syntrichia with propaguloid leaf apices are definitely distinct from South American and Antarctic S. lithophila and S. frigorideserticola and the correct name for them is S. abruptinervis comb. nov., based on Tortula abruptinervis.
Sentidos del abordaje de las formas humorísticas en sexto año de Literatura del nivel secundario: tensiones institucionales, reconocimientos e interpelaciones
Authors:   , García Cejas Juan Bautista
Published: December 2022

La investigación indaga los sentidos que docentes de escuelas secundarias de gestión estatal de la ciudad de La Plata le imprimen al abordaje de las formas humorísticas, unidad temática de carácter prescriptivo de la materia Literatura en sexto año del nivel secundario. El diseño curricular correspondiente contiene un corpus sugerido de textos cuya lejanía en tiempo y/o espacio, así como la posibilidad ofrecida de incorporación de textos ajenos al documento, vuelve pertinentes las preguntas sobre el papel de los reconocimientos, las interpelaciones y las posibles tensiones institucionales en los modos en que lxs docentes abordan la mirada humorística y los respectivos materiales incorporados en clase. Interviene en este núcleo problemático general el carácter marcadamente etario, sociocultural y anímico del efecto cómico y su carácter disruptivo respecto a normas y expectativas sociales naturalizadas, en el marco de una tradición escolar marcadamente higienista y aséptica pero actualmente porosa, atravesada por los procesos sociales de mediatización y subjetivación del saber. Asimismo, se investigan los discursos de lxs docentes sobre sus propias trayectorias referidas a los consumos y resignificaciones de aquellos materiales humorísticos que incorporan en las aulas, así como su direccionamiento político-ideológico.
Use Online Journal Club Events to Train the Educational Research Literacy: Research and Development at ResearchIC
Authors: Lin Jingjing
Published: December 2022

The development of Graduate Research Students’ research literacy (RL) requires intensive training in both the reading and writing of scientific literature. However, current approaches in many universities cannot well prepare these students to conduct advanced research. This paper describes the research and development of an educational initiative ResearchIC, which uses asynchronous online journal club events to teach research students in the field of education science on reading educational research literature. This initiative has a potential global impact on RL training by providing the platform and events as Open Educational Resources
Solving the Reading Crisis--Take 2: The Case for Differentiated Assessment
Authors: Kamhi Alan
Published: December 2022

The way to eliminate high levels of reading failure is to differentiate word recognition from domain-general reading comprehension and specific subject knowledge in high stakes assessments. This differentiation will focus attention on the true crisis in American education--- knowledge deficiencies in the sciences, history, math, literature and other subject areas that are important for success in the 21st century.
To the ontogenesis of aeschynite in feldspar vein no. 31 оf the Vishnevye Gory, Southern Urals
Authors: Popov V.A. , Blinov I.A. , Popova V.I.
Published: December 2022

Small grains of accessory aeschynite in feldspar vein no. 31 of Vishnevye Mountains (South Urals) co-crystallize with late growth zones of feldspar crystals, as well as with ilmenite, titanomagnetite, muscovite, zircon, monazite, thorite, rutile, columbite and other minerals. Crystallization of aeschynite was followed by its metamict decay and formation of a nanocrystalline structure and further repeated dissolution and metasomatosis along microfractures of the mineral aggregate. Metasomatosis of aeschynite was accompanied by the formation of microporosity in muscovite-ilmenite aggregates at the contact with aeschynite grains.
Garnet mineralization associated with late magmatic and hydrothermal-metasomatic processes in dunites of the Nizhny Tagil clipyroxenite-dunite massif, Central Urals
Authors: Stepanov S.Yu. , Palamarchuk R.S. , Shilovskikh V.V. , Artemiev D.A. , Korneev A.V. , Kozin A.K.
Published: December 2022

The miarolitic dunites of the Nizhny Tagil massif (Central Urals), the structure of miaroles and the principles of co-occurrence of minerals are studied. Garnets from miaroles are characterized in details and are compared with those from chromitites and metasomatites after dunites. The structure of miarolitic dunites and miaroles is described using ontogenic approaches. The structure and composition of garnets are studied by SEM and LA-ICP-MS. Three assemblages of garnets are established in rocks of the Nizhny Tagil massif: Cr-andradite in miarolitic dunites, uvarovite in massive veined chromitites and demantoid in metasomatites after dunites. Garnets from all assemblages belong to the ugrandite group and are characterized by specifc features of chemical composition including higher Cr2O3 content. Garnets are also characterized by contrasting concentrations of trace elements, such as V, Mn and Ti, as well as differences in REE pattern. A paragenetic sequence of formation of major rock-forming minerals is suggested for dunites, chromites and metasomatites after dunites of the Nizhny Tagil massif.
Teachers’ Opinions on the Forms, Causes, Consequences, and Possible Solutions to Deviant Behavior Among Senior School Students in Ilorin, Nigeria
Authors: Bolanle Bello Muhinat
Published: December 2022

This research examined teachers’ opinions on the forms, causes, and consequences of deviant behavior among senior school students in Ilorin South Local Government Area in Nigeria. The study adopted a descriptive form of survey research. The study population consisted of teachers of public senior secondary schools in Ilorin South; the study group was comprised of 322 teachers selected from 23 schools in the area using the purposive sampling technique. A questionnaire designed by the researcher with 28 items using a four-point Likert scale was used to elicit the necessary data from the respondents. The tool was checked for content validity and the split-half method revealed a reliability index of 0.68. A descriptive statistical method of percentages was used to answer the research question. The findings revealed that lateness, truancy, disrespect of the school authority, and examination malpractice were some of the forms of deviant behavior prevalent among the students. Also, access to illicit drugs and over- or under-pampering of children were considered some of the causes of deviant behavior, while academic failure, increased dropout rates, increased social vices, and an inconducive teaching and learning environment were thought to be the consequences of deviant behavior. Therefore, the provision of adequate facilities, monitoring of students’ activities at all times, and professional counselling are possible solutions to the problem of deviant behavior among the students.
The constitutional principle of common welfare at a time of a pandemic in Poland
Authors: Budzanowska Anna Teresa , Radziewski Mariusz
Published: December 2022

RESEARCH OBJECTIVE: The objective of the article is to analyse legislative acts introduced in Poland in response to COVID-19 pandemic (the so-called anti-crisis shields), which led to a clash between fundamental rights and constitutional principles and triggered a debate on systemic transgression and the principles that limit the government’s activities directed at citizens.   

 THE RESEARCH PROBLEM AND METHODS: COVID-19 led to attempts undertaken by the Polish government to redefine the constitutional strategies established by the Solidarity generation by choosing a strategy to deal with the crisis based on limiting citizens’ rights. This led to doubts triggered by the collision of this strategy with constitutional norms. The method used in the study was a legal-doctrinal comparative analysis and a synthesis of the literature.  

 THE PROCESS OF ARGUMENTATION: The article presents the determinants underlying the creation of constitutional principles in Poland embedded in the context of the common good as the principium which guides the relationships between the state and its citizens. The doctrinal transgression resulting from the government’s attempts to fight against COVID-19 was analysed and conclusions concerning the threats to the political system in the context of the governmental attempts to reinterpret the concepts fundamental to the democratic state of law were drawn.  

RESEARCH RESULTS: COVID-19 proved that the existing regulations are not sufficient to secure the principle of the common good as an underlying principle of the government’s activities. Crises become a pretext for decision-makers to introduce such laws which prioritise the interests of the authorities over the interests of citizens. 

 CONCLUSIONS, INNOVATIONS, AND RECOMMENDATIONS: It is recommended to consider the introduction of extra legislative mechanisms that would prevent the primacy of the interests of the state to take precedence over the interests of citizens in the future.
How Do You Picture a Genius? Children’s Images of Outstanding People
Authors: Łukasiewicz-Wieleba Joanna , Baum Alicja
Published: December 2022

The aim of the research is to investigate children’s ideas about outstanding people (geniuses). Three research questions were posed to 38 children aged 8–9 years: How do children imagine a genius? What gender do they identify with a genius? and What are the emotions of the genius they imagine? The research used the projection method, in which the children were asked to draw a genius and to add a description to the drawing. Qualitative analysis was conducted on the results; the codes and categories appearing in the drawings and descriptions were identified.

The research showed that children envision geniuses as both men and women (women although less frequently); in one case, it was said that a genius is everyone. Most often they were seen as scientists, but athletes, historical figures, characters from fairy tale or advertisements, or ordinary real people were described as well. The characters drawn by the children were mostly positive: attractive, elegant, and active. Only a few features testified to negative emotions accompanying the idea of a genius: being ridiculed, helpless, or disliked. The children’s conceptions of geniuses indicated that they are people (not traits) who stand out from others with their actions, appearance, and achievements and are more likely to be a man. These findings require further investigation, particularly in the context of creating labels and stereotypes about above-average people and the outstanding capabilities of women and men.
Types of Relationships Between the Family of a Gifted Child and the School and Other Environments That Support the Child’s Development
Authors: Stańczak Małgorzata
Published: December 2022

The purpose of this article is to describe and clarify the relationships that are found between families of talented children and schools, institutions, and other organizations engaged in the development of children’s potential. The developmental concepts of talents prevalent in the current discourse emphasize their dynamic and interactive nature, meaning that the development of children’s abilities is processual and proceeds in the course of intricate, time-dependent interactions between internal and external factors. A significant role is played by the influence from close social circles. From this viewpoint, positive relationships between the family and school or other social environments may help children’s capabilities to flourish.

The article draws on data originating from individual, in-depth interviews conducted with 18 families raising children with special academic, artistic, or athletic talents. The analysis identified three types of relationships between families and schools, institutions, and other organizations supporting the development of gifted children: cooperation, conflict, and natural development of a child’s talent. However, there were evident differences depending on the type of talent shown by the child, the stage in the education system they were in, and the specific profile of the school, educational institution, or organization conducting a given type of education.

Armed with knowledge on the relationships between family and school and other social environments, it is possible to both understand and mold them in accordance with the expectations of all parties and the needs of the gifted child.
Assessment of the Polish Diaspora’s Access to Education in the Toronto Metropolitan Area and Their Evaluation of the Level of Education in the Context of Quality of Life
Authors: Ziółkowska-Weiss Kamila
Published: December 2022

The main objective of the article is to depict access to education, both in terms of objective factors (quality of life) and subjective factors (standard of living), in the assessment of the Polish community living in the greater Toronto metropolitan area (GTA). The results of the research are presented on the basis of a questionnaire conducted among 583 Polish people living in the GTA. The results confirm that the Canadian Polish community evaluates highly the schools and other educational institutions operating within the study area. Another goal of the research was to investigate the possible influence of gender, income, or household size on the evaluation of access to education, which translates into a higher assessment of quality of life. In the study, the women and the respondents with higher income rated access to education more highly, while people in households with two to four people evaluated it the highest.
New Challenges Faced by the Polish Institutions of Preschool and Early-School Education (ECEC) in the Context of the War in Ukraine
Authors: Karbowniczek Jolanta , Ordon Urszula , Łapot Mirosław
Published: December 2022

The subject-matter of the research presented in this article is the preparation of Polish preschool and early-school education for work with refugee children that have fallen victim to the war in Ukraine. The research is a review one, and the analysis of Polish and foreign literature relevant to the matters referred to in the title of the article is included in it. As the result of the conducted archive and library searches, it was ascertained that, hitherto, rather little research into this problem has been conducted in Poland (the reason for which fact is the absence of previous experiences with a minor being a war refugee), and also rich relevant experiences in the countries of the West, confirmed by the extensive literature of the subject. This article indicates the principal directions of research and activities – the problem of war trauma as experienced by a child, supporting the families of refugee children, and providing an ECEC teacher with competences required for the purpose of work with a child refugee afflicted by war. This article constitutes a sui generis prolegomena of research the objective of which is to prepare Polish ECEC teachers for facing the challenges connected with war in Ukraine and the presence of an Ukrainian child refugee in the Polish institutions of education.
Values in Ethics Teaching in Grades 3 to 6 of Finnish Basic Education
Authors: Suwalska Arleta
Published: December 2022

The article begins with a review and analysis of the literature on educational reform in Finland, with particular reference to values education and secular ethics. The analysis of the curriculum began with a review of the literature on secular ethics in Finnish basic education. The next stage was to analyse the curriculum along with the curricular guidelines and support for primary schools in grades 3–6, especially with regard to what is applicable to all schools in Finland; this involved a review of the literature on educational reform in Finland, values in teaching and secular ethics. The article addresses a key issue in curriculum policy: ethics education in grades 3–6. The article explores what is embodied in this policy, especially the objectives of the subject of ethics.

 The problem method and critical discourse analysis were applied to the study of documents concerning educational reform and the study of discourses in political rhetoric. The problem method is based on an educational phenomenon related to time and society, so it was necessary to contrast the different views presented in contemporary Finnish education and to examine various consistent factors. Education here is thus an interaction between the various sets of teachers’ values and the ongoing construction of students’ values. This method of primary education encourages appropriate conditions for lifelong learning for each student. Suggested lessons may include discussions with students about values so that students perceive the variance in values and are able to think about them in a constructive and critical manner.
Education Through Nature (and With Nature) as the Source of a Child’s Resilience: The Educational and Healing Context of a Forest
Authors: Błasiak Anna
Published: December 2022

The objective of the article is to present the healing and educational properties of a forest in the context of the digital and consumerist reality of the 21st century and to discuss education for resilience as a specific kind of mental strength, inner power, and ability to cope with obstacles by using one’s own resources and reaching for social support. The research question was formulated as follows: What is the role of education through nature (and with nature) – an important element of which is a forest – in developing and reinforcing resilience in children? The choice of subject is justified by the social and cultural changes, which force a person to face new challenges and expectations. The dynamics of those changes leaves the modern person little time to think about, try to understand, and give meaning to the new conditions of life. Resilience may be a construct that facilitates adaptation to the changing and fragile reality and it may be developed and reinforced through contact with nature, that is, in a forest. In terms of its methodological aspects, the article includes research of a theoretical nature. The author has carried out a synthetic and analytical review of selected books, as well as an analysis of the existing data related to the issue in question.
Analysis of the variability of the manifestation of lies in social interactions
Authors: Karpova E. A. , Kukulite T. G.
Published: December 2022

The article presents an analysis of the concepts of the manifestation of lies in various social interactions. The concepts of E. Goffman, C. McCornack, B. De Paulo, P. Ekman, O. Fry, V. V. Znakov and others. The reasons, features, aspects and conditions for the occurrence of lies are indicated. It is shown that the occurrence of lies is due to the inﬂuence of the surrounding social context. Particular attention is paid to the deﬁnition of types of lies. The main factors inﬂuencing the formation of various types of lies are emphasized. Attention is focused on the results of the attitude towards lies of participants in business communications. Conclusions are drawn about the variability of the manifestation of lies.