bluuebunny/crossref_metadata_2025 huggingface dataset:
A favorable suture method for size-mismatched nerve transfer: comparison with standard perineural suture in an experimental rat study
Authors: Iwabuchi Sho , Hara Yuki , Yoshii Yuichi , Ikumi Akira , Mishima Hajime , Yamazaki Masashi
Published: September 2023

Background

In nerve transfer for peripheral nerve injury, it is sometimes necessary to suture size-mismatched nerves. In 1993, a favorable suture method called the Ochiai suture method for size-mismatched nerve transfer was reported. However, there is currently a lack of substantial evidence beyond the original report. Therefore, this study aimed to verify the advantages of using the Ochiai suture method for size-mismatched nerve transfer.

Methods

A total of 18 rats were evaluated in this study and randomly divided into two groups. All rats underwent femoral to sciatic nerve transfer. Specifically, group A (n = 10) underwent the Ochiai suture method, while group B (n = 8) underwent the perineural suture method. After 12 weeks postoperatively, we conducted the sciatic functional index (SFI) test, measured muscle wet-weight, and performed histological evaluations. All data were compared between the two groups, with Welch’s t test for normally distributed data and Mann-Whitney's U test for non-normally distributed data. Statistical significance was set at p < 0.05.

Results

The mean number of axons was significantly greater in group A than in group B at 5 mm distal to the stump (p = 0.04). Additionally, the average axonal diameter was significantly greater in group A than in group B at 5 mm and 10 mm distal to the stump (p < 0.01 and p < 0.01, respectively). However, the SFI test and measured muscle wet-weight values showed no significant differences between the two groups.

Conclusions

Our study revealed that the Ochiai suture method for size-mismatched nerve transfer in rats increases the regenerative axon numbers and diameters. These findings suggest that the Ochiai suture method could be a valuable approach for achieving effective motor function restoration in cases of size-mismatched nerve transfer.
Accuracy of augmented reality with computed tomography-based navigation in total hip arthroplasty
Authors: Hasegawa Masahiro , Naito Yohei , Tone Shine , Sudo Akihiro
Published: September 2023

Background

Augmented reality (AR) provides the surgeon with direct visualization of radiological images by overlaying them on the patient. This study aimed to evaluate the accuracy of cup placement using a computed tomography (CT)-based AR navigation system.

Methods

Sixty-five prospectively enrolled patients underwent primary cementless total hip arthroplasty (THA) in a supine position using this novel AR navigation system, and changes in pelvic flexion angle (PFA) were evaluated. Absolute navigation errors were defined as the absolute differences between angles in the intraoperative navigation record and those measured on postoperative CT. Factors affecting the absolute navigation error in cup alignment were determined.

Results

Mean absolute change in PFA between preoperative CT and reduction was 2.1° ± 1.6°. Mean absolute navigation errors were 2.5° ± 1.7° in radiographic inclination (RI) and 2.5° ± 2.2° in radiographic anteversion (RA). While no factors significantly affecting absolute navigation error were found for RI, absolute change in PFA between preoperative CT and reduction correlated significantly with the absolute navigation error for RA.

Conclusion

This CT-based navigation system with AR enabled surgeons to place the cup more accurately than was possible by freehand placement during THA in a supine position.
Incidence and root causes of surgery cancellations at an academic medical center in Iran: a retrospective cohort study on 29,978 elective surgical cases
Authors: Naderi-Boldaji Vida , Banifatemi Mahsa , Zandi Raheleh , Eghbal Mohammad Hossein , Nematollahi Milad , Sahmeddini Mohammad Ali
Published: September 2023

Introduction

Canceling scheduled surgeries on the day of surgery places a heavy burden on healthcare providers and has psychological, social, and financial consequences on patients and their families. This study aimed to investigate the main reasons for cancellations of elective procedures and provide appropriate recommendations to reduce the rate of such avoidable cancellations.

Methods

Data were collected retrospectively from all consecutive elective cases scheduled for various elective surgeries from January 1, 2020 to March 31, 2022 at Namazi Teaching Hospital, a major referral center in southern Iran with a capacity of 938 beds. Daily data were collected on the number of planned electives, cancellations, and reasons for cancellations. Surgical cancellation reasons were categorized as patient-related, surgeon-related, hospital/system-related, and anesthesia-related. Data were expressed as frequency (percentage) and analyzed with SPSS version 19 software.

Results

The cancellation rate on surgery day for elective procedures in all fields was 6.3%. The highest cancellation rate was related to minor surgeries (19%), followed by urology (8%), pediatrics (7%), and plastic surgery (7%). The most common reasons for cancellation were patients not suitable for the procedure (37%), followed by patients who did not follow instructions (10%), lack of time (10.5%), and equipment/supplies problems (10%), and refusal to consent (6%).

Conclusions

According to this study, patients’ unsuitability for surgery, non-compliance with instructions, lack of time, and problems with equipment/supplies are the main reasons for canceling surgery. Proper preoperative assessment and preparation of patients and improved communication between medical teams and patients reduce the cancellation of booked surgeries.
A methylation- and immune-related lncRNA signature to predict ovarian cancer outcome and uncover mechanisms of chemoresistance
Authors: Chen Lu , Gao Wujiang , Lin Li , Sha Chunli , Li Taoqiong , Chen Qi , Wei Hong , Yang Meiling , Xing Jie , Zhang Mengxue , Zhao Shijie , Xu Wenlin , Li Yuefeng , Long Lulu , Zhu Xiaolan
Published: September 2023

Tumor-associated lncRNAs regulated by epigenetic modification switches mediate immune escape and chemoresistance in ovarian cancer (OC). However, the underlying mechanisms and concrete targets have not been systematically elucidated. Here, we discovered that methylation modifications played a significant role in regulating immune cell infiltration and sensitizing OC to chemotherapy by modulating immune-related lncRNAs (irlncRNAs), which represent tumor immune status. Through deep analysis of the TCGA database, a prognostic risk model incorporating four methylation-related lncRNAs (mrlncRNAs) and irlncRNAs was constructed. Twenty-one mrlncRNA/irlncRNA pairs were identified that were significantly related to the overall survival (OS) of OC patients. Subsequently, we selected four lncRNAs to construct a risk signature predictive of OS and indicative of OC immune infiltration, and verified the robustness of the risk signature in an internal validation set. The risk score was an independent prognostic factor for OC prognosis, which was demonstrated via multifactorial Cox regression analysis and nomogram. Moreover, risk scores were negatively related to the expression of CD274, CTLA4, ICOS, LAG3, PDCD1, and PDCD1LG2 and negatively correlated with CD8+, CD4+, and Treg tumor-infiltrating immune cells. In addition, a high-risk score was associated with a higher IC50 value for cisplatin, which was associated with a significantly worse clinical outcome. Next, a competing endogenous RNA (ceRNA) network and a signaling pathway controlling the infiltration of CD8+ T cells were explored based on the lncRNA model, which suggested a potential therapeutic target for immunotherapy. Overall, this study constructed a prognostic model by pairing mrlncRNAs and irlncRNAs and revealed the critical role of the FTO/RP5-991G20.1/hsa-miR-1976/MEIS1 signaling pathway in regulating immune function and enhancing anticancer therapy.
Unilateral diaphragmatic palsy and pleuropericarditis in a patient with granulomatosis with polyangiitis: a case report
Authors: Risal Ujjwol Prasad , Pangeni Raju Prasad , Pandey Rakshya , Regmi Pradeep Raj , Karki Aditi , Shah Avish
Published: September 2023

Background

Granulomatosis with polyangiitis (GPA) is a rare small vessel vasculitis predominantly affecting upper and lower respiratory tract and kidneys. Unilateral diaphragmatic palsy could be a rare manifestation of GPA. Here we report a case of GPA in a 45-year-old male with unilateral diaphragmatic palsy with pleuropericarditis.

Case presentation

We report a case of a 45-year-old Khas male who presented with acute onset chest pain and shortness of breath who had elevated right hemidiaphragm, bilateral pleural effusion and pericardial effusion who was later diagnosed as GPA.

Conclusions

GPA should be suspected in all patients with diaphragmatic palsy and pleuropericarditis with appropriate clinical and laboratory picture.
Piloting the integration of SMART Recovery into outpatient alcohol and other drug treatment programs
Authors: Manning V. , Roxburgh A. D. , Savic M.
Published: September 2023

Background

Research suggests peer support groups can amplify and extend treatment effects and enhance long-term recovery from Alcohol and Other Drug (AOD) problems. However, they are rarely integrated into outpatient treatment programs, resulting in a missed opportunity for peer-to-peer learning, and increased connection to others social networks where people want to reduce or cease substance use.

Method

In this mixed-methods study, we examined the uptake, participant experiences and impacts of Self-Management and Recovery Training (SMART) when embedded in three public AOD treatment programs in a pilot program in Australia. Groups were delivered initially in-person but transitioned online during the COVID-19 pandemic.

Results

A total of 75 SMART Recovery groups were run by the pilot sites, with an average attendance of 6.5 people per meeting. Among Participants (N = 31) who completed the survey, 94% reported benefits relating to substance use (i.e., reduction/ successful maintenance of abstinence), 71% reported improvements in their mental health and wellbeing, 74% reported improvements in their physical health, and 81% reported feeling better connected with others. In-depth qualitative interviews were conducted with 10 participants to explore their experiences. Thematic analysis revealed four themes: motivation to attend, active ingredients, views on the integration of SMART into formal AOD, and the advantages and disadvantages of online groups.

Conclusion

Taken together, these findings suggest embedding SMART Recovery in AOD treatment is a worthwhile endeavour. This was indicated by a good uptake and evidence of multiple and unique benefits to participants over and above their usual care, notably, better management of their AOD use, health, wellbeing, and sense of connection with others.
Exploring the role of autistic traits and eating disorder psychopathology on mentalising ability in the general population
Authors: Fithall Kate , Gray Indigo E , Linardon Jake , Phillipou Andrea , Donaldson Peter H , Albein-Urios Natalia , Enticott Peter G , Fuller-Tyszkiewicz Matthew , Kirkovski Melissa
Published: September 2023

Background

This study evaluated the role of overlapping traits and characteristics related to autism spectrum disorder (autism) and anorexia nervosa (AN) in the general population, and the impact of these traits on mentalising ability.

Methods

A sample of young adults (N = 306), aged 18–25 years, was recruited to complete an online study that consisted of 4 measures: the Autism-Spectrum Quotient, Eating Disorder Examination Questionnaire, the Mentalization Scale, and the Reading the Mind in the Eyes task.

Results

Higher levels of autistic traits, particularly difficulty with attention switching, were associated with increased eating disorder psychopathology. Overall, autistic traits and eating disorder psychopathology were related among females, but not males. Difficulty with attention switching, however, was related to eating disorder psychopathology among both females and males. Autistic traits also appear to have a greater role in mentalising ability than does eating disorder psychopathology.

Conclusion

The role of attention switching in overlapping traits of autism and eating disorder psychopathology needs to be more comprehensively evaluated by future research, as does the role of biological sex. Expanded knowledge in this field will help to better understand and evaluate symptoms at presentation, leading to clearer diagnoses and potentially better treatment outcomes.
Effects of lifestyle physical activity and sedentary behaviour interventions on disease activity and patient- and clinician- important health outcomes in rheumatoid arthritis: a systematic review with meta-analysis
Authors: Brady Sophia M. , Veldhuijzen van Zanten Jet J. C. S. , Dinas Petros C. , Nightingale Tom E. , Metsios George S. , Elmsmari Saleh M. A. , Duda Joan L. , Kitas George D. , Fenton Sally A. M.
Published: September 2023

Background

Lifestyle physical activity (PA) is defined as any type of PA undertaken as part of daily life. It can include engagement in activities of daily living (i.e., household chores, gardening, walking to work), incidental PA, walking and/or reducing sedentary or sitting behaviours (SB). Regular PA is recommended for people with Rheumatoid Arthritis (RA) to reduce disease activity and systemic inflammation, as well as to improve patient- and clinician-important health outcomes. However, there is no summarised evidence of the effectiveness of interventions specifically targeting lifestyle PA and SB in this population. The aims of this systematic review with meta-analysis were to evaluate interventions targeting lifestyle PA and/or SB on 1) disease activity; 2) PA, SB and 3) patient- and clinician-important outcomes in people with RA.

Methods

Eight databases [Medline, Cochrane Library CENTRAL, Web of Science, PsychINFO, Cumulative Index to Nursing & Allied Health Literature, Scopus, Excerpta Medica database and Physiotherapy Evidence Database] were searched from inception-August 2022. Inclusion criteria required interventions to target lifestyle PA and/or SB, conducted in adults with RA, assessing patient- and/or clinician-important outcomes.

Results

Of 880 relevant articles, 16 interventions met the inclusion criteria. Meta-analyses showed statistically significant effects of interventions on disease activity (standardised mean difference = -0.12 (95% confidence interval = -0.23 to -0.01, I2 = 6%, z = 2.19, p = .03), moderate-to-vigorous PA, light/leisure PA, steps, functional ability, and fatigue. Whereas, no intervention effects were visualised for total PA, pain, anxiety or quality of life.

Conclusions

Lifestyle PA interventions led to increased PA, reductions in SB and improvements in disease activity and other patient- and/or clinician-important health outcomes in people with RA. Future interventions should be less heterogenous in content, structure, focus and outcome measures used to aid understanding of the most effective intervention components for improving health. More SB interventions are needed to determine their effectiveness at producing clinical benefits.
Toxoplasma gondii adhesion and apoptosis of chicken erythrocytes
Authors: Li Chenghuan , Zhang Xiaohan , Sang Xiaoyu , He Yanhong , EI-Ashram Saeed , Ding Yingying , Jiang Tiantian , Yang Na
Published: September 2023

Toxoplasma gondii is thought to infect all nucleated cells in warm-blooded animals, including poultry, mammals, and humans. However, it is unclear whether T. gondii can infect chicken erythrocytes due to the nucleated nature of these cells. Due to the special role of chicken erythrocytes in innate immunity, we investigated the cell‒cell interaction between T. gondii and erythrocytes to elucidate the role of chicken erythrocytes in T. gondii infection. Cellular apoptosis was analyzed by transwell assay and flow cytometry. An immunofluorescence method was used to examine the reorganization of vimentin during T. gondii infection in both Vero cells and chicken erythrocytes. The reorganization of actin was evaluated to further examine the invasion capacity of tachyzoites on chicken erythrocytes during infection. We discovered that T. gondii can adhere to but not invade chicken erythrocytes and eventually cause apoptosis in chicken erythrocytes. When tachyzoites were cocultured with chicken erythrocytes in vitro, the transcriptional levels of T. gondii MIC3, ROP16, and ROP18 were significantly decreased. In addition, the rearrangement of host cell vimentin, a type III cytoskeleton protein regulated by T. gondii infection, was not observed. Similarly, the parasite-induced ring-shaped actin structure was not formed in the host-parasite junction. T. gondii (RH strain) tachyzoites preferentially invaded Vero cells and replicated in chicken blood monocytes, but they were not found in chicken erythrocytes. These findings showed that although T. gondii could attach to the surface of chicken erythrocytes, but couldn’t invade successfully. Interestingly, we found that the T. gondii secretome, lysates, and intact tachyzoites could cause apoptosis of chicken erythrocytes, which suggested a complex mechanism involved in the apoptosis of chicken erythrocytes induced by T. gondii. This study elucidated that T. gondii could not infect nucleated chicken erythrocytes and enriched our understanding of the transmission mechanism of T. gondii among avian species.
The qualities of patients interested in using a game-based digital mental health intervention for depression: a sequential mixed methods study
Authors: Lukka Lauri , Salonen Antti , Vesterinen Maria , Karhulahti Veli-Matti , Palva Satu , Palva J. Matias
Published: September 2023

Background

Digital interventions are typically evaluated by their effectiveness and engagement, while the characteristics of patients who perceive them to be attractive have remained poorly understood. This challenges user-centered intervention development but also presents an avenue to improve intervention efficacy and engagement. Our objective was to characterize people to whom game-based interventions appeal to with a focus on their mental health backgrounds and prior digital game experiences.

Methods

We performed a sequential mixed methods study with adults suffering from major depressive disorder (MDD) who participated in a randomized controlled clinical trial studying the effectiveness of a game-based digital intervention for depression. First, randomly chosen participants were interviewed (N = 22), and the transcribed data were analyzed inductively. Then, focusing on the themes established through the interview data, we triangulated the findings using complementary questionnaire data (N = 445).

Results

The interview data yielded four themes that we illuminated with quantified questionnaire data. (T1) The participants had enduring and diverse psychiatric symptomology: 73% had been diagnosed with a comorbid disorder in addition to depression. (T2) Participants had received at least some treatments that had not led to full remission of depression. 92% currently received therapeutic support, psychiatric medication, or both. (T3) Many participants had close relationships with digital gaming and played actively: on average, for 13 h a week on various gaming platforms and in various genres. (T4) Some participants used gaming to manage their psychiatric symptoms, and 76% found that playing helped them feel better.

Conclusions

Identifying and characterizing people attracted to game-based therapeutic interventions can catalyze intervention development and improve their efficacy. We found that game-based interventions have appealing potential across diverse psychiatric symptoms and for people with prior or existing treatments. Game-based interventions may appeal particularly to active players and offer a promising alternative to the self-treatment usage of entertainment games.
The role of work–family conflict in the association between long working hours and workers’ sleep disturbance and burnout: results from the sixth Korean Working Conditions Survey
Authors: Baek Seong-Uk , Won Jong-Uk , Yoon Jin-Ha
Published: September 2023

Background

The effect of long working hours on mental health has drawn great social attention in recent years.

Aims

We investigated how work–family conflict mediates the associations between long working hours and sleep disturbance and burnout.

Method

We included 19 159 individuals from a nationally representative sample of workers in South Korea. We decomposed the total effect into a direct effect (long working hours → sleep disturbance or burnout) and an indirect effect (long working hours → work–family conflict → sleep disturbance or burnout). Logistic mediation models were used.

Results

Long working hours were associated with increased risks of work–family conflict, sleep disturbance and burnout. The longer the working hours, the stronger the direct and indirect effects. The odds ratios of the direct effects of long working hours on sleep disturbance were 1.64 (95% CI 1.39–1.95) for 49–54 h/week and 1.66 (95% CI 1.37–2.01) for ≥55 h/week; those of the indirect effects were 1.16 (95% CI 1.12–1.21) for 49–54 h/week and 1.27 (95% CI 1.21–1.33) for ≥ 55 h/week. Similarly, odds ratios of the direct effects of long working hours on burnout were 1.18 (95% CI 1.05–1.33) for 49–54 h/week and 1.20 (95% CI 1.04–1.37) for ≥55 h/week; those of the indirect effects were 1.11 (95% CI 1.09–1.15) for 49–54 h/week and 1.20 (95% CI 1.16–1.24) for ≥55 h/week.

Conclusions

Our results suggest that work–family conflict mediates the associations between long working hours and sleep disturbance and burnout. Longitudinal studies should be followed to confirm the causal relationship.
Effects of Sex Hormones on Vascular Reactivity in Boys With Hypospadias
Authors: Lucas-Herald Angela K , Montezano Augusto C , Alves-Lopes Rheure , Haddow Laura , O’Toole Stuart , Flett Martyn , Lee Boma , Amjad S Basith , Steven Mairi , McNeilly Jane , Brooksbank Katriona , Touyz Rhian M , Ahmed S Faisal
Published: September 2023

Background

Arteries from boys with hypospadias demonstrate hypercontractility and impaired vasorelaxation. The role of sex hormones in these responses in unclear.

Aims

We compared effects of sex steroids on vascular reactivity in healthy boys and boys with hypospadias.

Methods

Excess foreskin tissue was obtained from 11 boys undergoing hypospadias repair (cases) and 12 undergoing routine circumcision (controls) (median age [range], 1.5 [1.2-2.7] years) and small resistance arteries were isolated. Vessels were mounted on wire myographs and vascular reactivity was assessed in the absence/presence of 17β-estradiol, dihydrotestosterone (DHT), and testosterone.

Results

In controls, testosterone and 17β-estradiol increased contraction (percent of maximum contraction [Emax]: 83.74 basal vs 125.4 after testosterone, P < .0002; and 83.74 vs 110.2 after estradiol, P = .02). 17β-estradiol reduced vasorelaxation in arteries from controls (Emax: 10.6 vs 15.6 to acetylcholine, P < .0001; and Emax: 14.6 vs 20.5 to sodium nitroprusside, P < .0001). In hypospadias, testosterone (Emax: 137.9 vs 107.2, P = .01) and 17β-estradiol (Emax: 156.9 vs 23.6, P < .0001) reduced contraction. Androgens, but not 17β-estradiol, increased endothelium-dependent and endothelium-independent vasorelaxation in cases (Emax: 77.3 vs 51.7 with testosterone, P = .02; and vs 48.2 with DHT to acetylcholine, P = .0001; Emax: 43.0 vs 39.5 with testosterone, P = .02; and 39.6 vs 37.5 with DHT to sodium nitroprusside, P = .04).

Conclusion

In healthy boys, testosterone and 17β-estradiol promote a vasoconstrictor phenotype, whereas in boys with hypospadias, these sex hormones reduce vasoconstriction, with androgens promoting vasorelaxation. Differences in baseline artery function may therefore be sex hormone-independent and the impact of early-life variations in androgen exposure on vascular function needs further study.
Starvation selection reduces and delays larval ecdysone production and signaling
Authors: Clark Jennifer M. , Gibbs Allen G.
Published: September 2023

Previous studies have shown that selection for starvation resistance in Drosophila melanogaster results in delayed eclosion and increased adult fat stores. It is assumed that these traits are caused by the starvation selection pressure, but its mechanism is unknown. We found that our starvation-selected (SS) population stores more fat during larval development and has extended larval development and pupal development time. Developmental checkpoints in the third instar associated with ecdysteroid hormone pulses are increasingly delayed. The delay in the late larval period seen in the SS population is indicative of reduced and delayed ecdysone signaling. An enzyme immunoassay for ecdysteroids (with greatest affinity to the metabolically active 20-hydroxyecdysone and the α-ecdysone precursor) confirmed that the SS population had reduced and delayed hormone production compared with that of fed control (FC) flies. Feeding third instar larvae on food supplemented with α-ecdysone partially rescued the developmental delay and reduced subsequent adult starvation resistance. This work suggests that starvation selection causes reduced and delayed production of ecdysteroids in the larval stage and affects the developmental delay phenotype that contributes to subsequent adult fat storage and starvation resistance.
Implementing a Sports Ultrasound Curriculum in Undergraduate Medical Education
Authors: Schroeder Allison N. , Amin Idris , Bowen Brady J. , Callender Shelley S. , Ferderber Megan , Kerr Hamish A. , Phillips Shawn F. , Romero Joshua M. , Rudolph Lauren , Vidlock Kathryn , Waterbrook Anna L. , Kruse Ryan C.
Published: September 2023

The utilization of sports ultrasound in the clinical practice of sports medicine physicians is growing rapidly. Simultaneously, ultrasound is being increasingly implemented as a teaching tool in undergraduate medical education. However, a sports ultrasound curriculum for medical students has not been previously described. In this article, we describe methods as well as barriers to implementing a sports ultrasound curriculum at the medical school level. Recommended content for the curriculum also is discussed. While educational goals and resources will vary among institutions, this article may serve as a general roadmap for the creation of a successful curriculum.
Adaptive sampling for nanopore direct RNA-sequencing
Authors: Naarmann-de Vries Isabel S. , Gjerga Enio , Gandor Catharina L.A. , Dieterich Christoph
Published: September 2023

Nanopore long-read sequencing enables real-time monitoring and controlling of individual nanopores. This allows us to enrich or deplete specific sequences in DNA sequencing in a process called “adaptive sampling.” So far, adaptive sampling (AS) was not applicable to the direct sequencing of RNA. Here, we show that AS is feasible and useful for direct RNA sequencing (DRS), which has its specific technical and biological challenges. Using a well-controlled in vitro transcript-based model system, we identify essential characteristics and parameter settings for AS in DRS, as the superior performance of depletion over enrichment. Here, the efficiency of depletion is close to the theoretical maximum. Additionally, we demonstrate that AS efficiently depletes specific transcripts in transcriptome-wide sequencing applications. Specifically, we applied our AS approach to poly(A)-enriched RNA samples from human-induced pluripotent stem cell–derived cardiomyocytes and mouse whole heart tissue and show efficient 2.5- to 2.8-fold depletion of highly abundant mitochondrial-encoded transcripts. Finally, we characterize depletion and enrichment performance for complex transcriptome subsets, that is, at the level of the entire Chromosome 11, proving the general applicability of direct RNA AS. Our analyses provide evidence that AS is especially useful to enable the detection of lowly expressed transcripts and reduce the sequencing of highly abundant disturbing transcripts.
Spatial and temporal community composition changes of Cumacea (Crustacea: Malacostraca: Peracarida) from the soft-sediment habitats of the Mediterranean coast of Israel
Authors: LUBINEVSKY HADAS , TOM MOSHE , CORBERA JORDI , KOULOURI PANAYOTA (YOLANDA)
Published: September 2023

The present study provides a zoogeographic and faunistic update on the cumacean species that inhabit the soft substrate habitats of the Israeli waters of the Mediterranean Sea. Published and new unpublished cumacean records are both used to enable an overview of a 74-year period of species composition and distribution, providing a broad perspective of temporal faunistic changes. As a result, 43 cumacean species have now been recorded from the Mediterranean coast of Israel. Previously unpublished results, starting from 2013, were derived from intensified sampling of the continental shelf and slope as well as the bathyal plain, and revealed eight new species records for the eastern part of the Mediterranean Sea. The cumacean community included species primarily of the Mediterranean zoogeographic province with several Mediterranean-Atlantic examples. Three species, postulated to be of Indo-Pacific origin were also previously recorded on the continental shelf of the area. Finally, species composition and structure of the continental shelf indicated spatial and temporal changes between 2010 – 2021, partly due to different sampling methods as well as anthropogenic activities that took place in the area. The continental slope and the bathyal plain seem to remain as relatively stable environments.
Historic adjacent concrete buildings strengthened by cable-ties under seismic pounding effects: A stochastic approach considering uncertain input parameters
Authors: Liolios Angelos , Stavroulaki Maria , Liolios Konstantinos , Konstandakopoulou Foteini
Published: September 2023

Cultural Heritage structures include existing old industrial framed reinforced concrete (RC) buildings. The present study deals with a stochastic numerical treatment for the pounding problem concerning the seismic interaction between historic adjacent framed structures strengthened by cable-ties (tension-only bracings) when the input parameters are uncertain. This problem concerns here the unilateral contact between neighbouring structures during earthquakes and is considered as an inequality problem of dynamic structural contact mechanics. The Monte Carlo method is used for treating the uncertainty concerning input parameters. The purpose here is to estimate numerically and to control actively the influence of the cable-ties on the seismic response of the adjacent structures. Finally, in a practical case of two seismically interacting historic framed reinforced concrete (RC) structures, the effectiveness of the proposed methodology is shown.
The genome sequence of the fork-jawed nomad bee, Nomada ruficornis (Linnaeus, 1758)
Authors: Falk Steven , Monks Joseph ,   University of Oxford and Wytham Woods Genome Acquisition Lab,   Darwin Tree of Life Barcoding collective,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: September 2023

We present a genome assembly from an individual male Nomada ruficornis (the fork-jawed nomad bee; Arthropoda; Insecta; Hymenoptera; Apidae). The genome sequence is 273.0 megabases in span. Most of the assembly is scaffolded into 16 chromosomal pseudomolecules. The mitochondrial genome has also been assembled and is 20.66 kilobases in length.
MASTERING TECHNICAL ENGLISH AT A FOREIGN LANGUAGE LESSONS IN A PROFESSIONAL EDUCATIONAL ORGANIZATION (FROM WORK EXPERIENCE). LEARNING TECHNICAL ENGLISH
Authors: Slepkova Faina T.
Published: September 2023

The article discusses fragments of teaching technical English in the

vocational education system from the experience of a teacher, specifically by

profession "Welder (manual and partially mechanized welding (surfacing))."

Mastering technical vocabulary at the initial stage goes through reading instructions

for the operation of household appliances in Russian, to hear and see the style of

technical translation, and only then do students proceed to reading the instruction

manual for professional tools and equipment in English, which makes it easier to

understand the foreign language text.
The state of the cytokine profile under the conditions of the immobilization stress development
Authors: Olekshij P. , Regeda M. , Hayduchok I.
Published: September 2023

The aim of our study is to elucidate changes in the content of pro-inflammatory interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) and anti-inflammatory cytokines interleukin-10 (IL-10) in the blood serum of guinea pigs in the dynamics of experimental immobilization stress.The dynamics of the immobilization stress is accompanied by a pronounced progression of the proinflammatory group of cytokines - TNF-α and IL-6 against the background of declining functional activity of IL-10 at all stages of their formation (3 rd, 5 th and 15 th days) with an advantage on the 3 rd day of the experiment. The data obtained indicate an imbalance of pro- and anti-inflammatory cytokines and impaired cytokinogenesis, which is important for the pathogenesis in immobilization stress.
„To także Różewicz”... Autor Niepokoju jako pisarz dla młodzieży
Authors: Dakowicz Przemysław
Published: September 2023

W artykule opisany został jeden ze słabiej znanych epizodów w pisarskiej biografii Tadeusza Różewicza. Poeta, którego miejsce w hierarchii artystycznej epoki było stosunkowo wysokie, w latach stalinizmu zdaje się poszukiwać kompromisu między pełnowartościową twórczością artystyczną a lansowanym przez czynniki oficjalne obrazem doskonałego świata komunistycznej utopii. Wyrazem tego rodzaju tendencji są niektóre wiersze z tomów Pięć poematów (1950), Czas który idzie (1951), Wiersze i obrazy (1952), Równina (1954), Srebrny kłos (1955). Teksty te zostały stosunkowo dobrze opisane, podczas gdy do niedawna niemal nieznane pozostawały krótkie utwory narracyjne, które Różewicz w latach 1952–1953 opublikował na łamach przeznaczonego dla młodzieży pisma „Płomyk”. Opowiadania Towarzysz Marian i Gwiazdy Budapesztu pozostają zasadniczo zgodne z obowiązującą wówczas tendencją socrealistyczną. Pierwsze z nich ukazuje wyidealizowany życiorys jednego z komunistycznych „świętych”, Mariana Buczka – przede wszystkim rzekomo bohaterskie ostatnie dni i godziny jego życia (Buczek ginie z bronią w ręku, podczas walki z niemieckim okupantem). Gwiazdy Budapesztu to z kolei równie jednowymiarowy obraz cywilizacyjnych, społecznych i technicznych zdobyczy komunizmu na Węgrzech. Autor artykułu podejmuje próbę analizy tych tekstów oraz ujrzenia ich na tle życia publicznego Polskiej Rzeczypospolitej Ludowej lat stalinizmu.
(Stary) poeta wysiaduje
Authors: Tomala Krystian Maciej
Published: September 2023

W niniejszym artykule autor omawia reprezentacje procesu twórczego w pisarstwie Tadeusza Różewicza. Odwołuje się do badań kulturowych (w tym badań antropologicznych stanowiących w tym wypadku inspirację dla psychoanalizy), gender studies, a przede wszystkim – do studiów nad męskościami w perspektywie zwrotu biologicznego, poszukując analogii pomiędzy Różewiczem i tytułową bohaterką dramatu Stara kobieta wysiaduje. Kluczowym pojęciem dla autora staje się kuwada – zjawisko szeroko zbadane niedawno na gruncie polskim przez Ewę Głażewską. Próba zaadaptowania teorii „wysiadywania” (jajka) przez „samca” na grunt badań literackich funduje interesujący obraz poety-kwoki i „przeżuwacza” zarazem. W konsumpcyjnym kontinuum kultury poeta jawi się jako ten, który z jednej strony pochłania dotychczasowy dorobek kulturowy, z drugiej zaś – wydala go w postaci własnego tekstu w specyficznym akcie fantazmatycznego porodu-defekacji – bolesnego i niemożliwego zarazem dla mężczyzny doświadczenia.
Radiowy potencjał teatru (nie)konsekwencji Tadeusza Różewicza
Authors: Zwolińska Barbara
Published: September 2023

W artykule przyglądam się tym cechom sztuk dramatycznych Tadeusza Różewicza, które są szczególnie atrakcyjne dla teatru radiowego, nieprzypadkowo zwanego teatrem wyobraźni. Na początku rozważań skupiam się na pojęciu teatru niekonsekwencji rozumianym przez samego twórcę, który wypowiadał się na ten temat w rozmowach z Konstantym Puzyną oraz z Kazimierzem Braunem, współautorem Języków teatru. Można odnieść wrażenie, że Różewicz niekoniecznie i niezawsze pisał z myślą o wystawianiu swoich sztuk w teatrze, że bliższa mu była koncepcja niesceniczności, sztuki literackiej przeznaczonej do czytania, opartej na akcji wewnętrznej i sile słowa (z nastawieniem na jego komunikatywność i użytkowość), cenił fragmentaryczność i otwarcie, opisujące „rozproszoną” rzeczywistość oraz „niescaloną” tożsamość bohaterów. Wątki poruszane przez rozmówców, skupiających się na cechach teatru niekonsekwencji i odnoszących się do konkretnych sztuk oraz ich scenicznych realizacji, pozwalają sformułować wniosek, że swego rodzaju braki i ogra-niczenia teatru scenicznego, sugerowane przez Różewicza, mógł choćby częściowo rekompensować teatr radiowy. Dalszą część rozważań poświęcam współbieżności wizji wykreowanej w sztukach Różewicza (i „dopowiadanej” przez niego w rozmowach ze znawcami teatru) z tą realizowaną przez twórców radia przy pomocy audialnych środków wyrazu.
Patricia’s Story: Living Appreciative Inquiry
Authors: Pagès Jean
Published: September 2023

Patricia Sennequier talks to Jean Pagès about what Appreciative Inquiry means to her and how it has helped heal certain wounds and given her confidence in her coaching.
Innovación para la gestión integrada del patrimonio, el paisaje y el turismo
Authors: Linares Gómez del Pulgar Mercedes , López Sánchez Marina , Merino del Río Rebeca , Tejedor Cabrera Antonio
Published: September 2023

Hoy en día la importancia de las herramientas digitales en las disciplinas vinculadas al patrimonio, al paisaje y al uso del territorio resulta innegable y conviene, por tanto, avanzar en la comprensión del papel que juegan no solo en el proceso de representación o análisis, sino en el seno del propio ejercicio proyectual. Esta obra se centra en la planificación, la investigación histórica y el proyecto de arquitectura sobre lugares de especial valor patrimonial, como son los grandes conjuntos arqueológicos, que poseen importantes claves de comprensión del entorno físico y medioambiental de la acción humana sobre el territorio. La obra se estructura en tres bloques de contenido: "conceptualización para una gestión integrada del patrimonio territorial", "estrategias e incorporación de nuevas tecnologías digitales" y, finalmente, "territorio, patrimonio y paisaje del bajo Guadalquivir".
Omega-3 Fatty Acids and COVID-19: Prevention or Adjuvant Therapy?
Authors: Gammone Maria Alessandra , D’Orazio Nicolantonio
Published: September 2023

The mechanisms of COVID-19 complications are multifactorial, including long-term tissue dam-ages from direct viral attack, dysregulation of both immunity and renin-angiotensin-aldosterone system and coagulation system, unresolved systemic inflammation and oxidative stress. Omega-3 polyunsaturated fatty acids (omega-3 or n-3 PUFAs) might have favorable effects on immunity, inflammation, oxidative stress at different stages of SARS-CoV-2 infection. Omega-3 and their metabolites including specialized proresolvin mediators, have shown effects in reducing pro-inflammatory cytokines, accelerating the resolution of chronic inflammation and restoring tissue homeostasis, and therefore offer a promising strategy against COVID-19. This article will discuss the inflammatory condition during COVID-19 pandemic, focus on the mechanisms that may contribute to the likely benefits of omega-3 and provide potential recommendations to pro-mote strategies for wellness.
Intelligent and Active Packaging System Application in Evaluating and Maintaining the Tuna (Thunnus Sp.) Fillets’ Quality at Cold Temperature
Authors: Latief Rindam , Dirpan Andi , Djalal Muspirah , Ramadhani Indah S. , Julyaningsih Andi H.
Published: September 2023

This study developed intelligent and active packaging combined for tuna fillets. The purposes of this study were to determine the colour change of packaging indicator labels and the effectiveness of edible coatings (citronella oil concentrations of 0%, 0.5%, and 1%), as well as to establish a correlation between the colour analysis values of intelligent indicator and observed spoilage criteria of tuna stored at refrigerated temperatures (4±1°C). The parameters tested included the determination of Total Volatile Bases Nitrogen, Total Plate Count, pH, and sensory analysis. The test was carried out every three days for 18 days, with two replications. The findings indicated that the intelligent indicator label (Bromothymol blue + Methyl Red (1:1)) changed colour from deep red to yellow and then green. Edible coating with 0.5% citronella oil gave the best result in this study. The correlation between the colour analysis of the intelligent indicators and the parameters of the fish spoilage test is positive, suggesting a consistent trend pattern in determining the degree of decay in tuna fillets. Correlation coefficient values vary from 0.98 to 0.99, showing a significant correlation. The combination of intelligent and active packaging in a single packaging system allows for monitoring tuna's quality while increasing its shelf life.
Cryoprotectant Effects on Duck Surimi During Frozen Storage
Authors: Ishamri Ismail , Huda Nurul
Published: September 2023

The surimi-like material made from duck (DSLM) was investigated on the freeze-thaw stability during 4 months of frozen storage using different low-sweetness cryoprotectants such as palatinose (PAL), trehalose (TRE), polydextrose (PLD), maltodextrin (MAL), sucrose and sorbitol (SS), and lactitol (LAC) at a 6% concentration. As compared to the CON, the inclusion of cryoprotectants significantly improved the water-holding capacity of all treated samples. Particularly, as compared to all of the cryoprotectants evaluated, the PLD and PAL samples displayed greater stability concerning Ca2+-ATPase activity, sulfhydryl concentration, and protein solubility. All samples' endothermic peaks declined over time, showing changes in thermal characteristics during storage. A scanning electron microscope (SEM) observation of the CON and LAC-treated samples after 4 months of frozen storage revealed an increase in the number of pores. These findings imply that low-sweetness PLD and PAL outperformed the usual cryoprotectant combination of sucrose and sorbitol (SS) and that they could be used in frozen DSLM. They provide greater water-holding capacity, anti-freezing characteristics, lowered sulfhydryl oxidation, increased protein solubility, and structural integrity, which renders them useful components for innovation in the frozen surimi-like material industry.
Políticas e questões atuais: avanços e desafios para o Serviço Social
Authors: César Monica De Jesus
Published: September 2023

A edição nº 53 da Em Pauta: teoria social e realidade contemporânea tem como dossiê temático Serviço Social, políticas e questões atuais, congregando artigos que abordam aspectos teóricos, metodológicos, éticos, políticos, técnicos e pedagógicos do Serviço Social e tratam da sua articulação com as políticas, lutas e movimentos sociais, suscitando reflexões sobre os seus desafios no atual contexto brasileiro e latino-americano.
A dimensão normativa da ética no Serviço Social
Authors: Mirales Rosana Mirales
Published: September 2023

O objeto de pesquisa que gerou material de análise para este artigo é a ética, compreendida como uma dimensão da práxis humana, uma capacidade do ser social que projeta a emancipação humana. O objetivo do artigo é refletir sobre a emancipação humana, na particularidade da ética no contexto profissional. Serão apresentados alguns resultados sintetizados da investigação realizada no Cress-PR, por meio de pesquisa documental com os processos de denúncia de infração ética do período de 2013 a 2018, quando se observou o processamento de denúncias de infrações éticas no Serviço Social. Para nortear a pesquisa documental do material no Cress-PR, realizada mediante parecer de ética em pesquisa, foi realizada revisão bibliográfica, identificando elementos que fundamentam o debate sobre ética na tradição marxiana, considerado o acervo do Serviço Social sobre o tema. Palavras-Chave: emancipação; ética; práxis; processos éticos; serviço social.
Quem é velho e quem é idoso no capitalismo contemporâneo? Reflexões sobre o envelhecimento de mulheres trabalhadoras
Authors: Lemos Amanda Dos S. Lemos
Published: September 2023

O envelhecimento populacional é uma realidade hoje. Vários são os fatores que permitiram essa conquista. Entretanto, a cada dia se intensificam os debates sobre o longeviver e o longeviver com dignidade. Apesar de ser um processo natural, muitos poderão ser os fatores sociais que agirão no processo do envelhecimento e na sua vivência. Dentro dessa perspectiva alguns grupos despertam preocupação, em função de como vivem a juventude e a fase adulta, o que impactará diretamente na sua velhice. Dentre esses grupos, chamamos atenção para a situação das (ex)trabalhadoras domésticas negras, a partir da experiência com institucionalização de pessoas idosas. À medida que nos aprofundamos nas peculiaridades da vida da classe trabalhadora, mais é válido questionarmos quem é velho e quem é idoso na sociedade brasileira. Palavras-Chave: envelhecimento; raça; etnia; classe trabalhadora; trabalho doméstico; capitalismo contemporâneo.
Contrarreformas da previdência no Brasil: expropriação dos direitos de docentes
Authors: Gonçalves André de Menezes , Melo Ana Isabel Souto , Carvalho Lilian Nascimento , Da Silva Maria Raisa Gomes
Published: September 2023

O texto objetiva debater as contrarreformas da previdência brasileira no cenário contemporâneo e porque a categoria de docentes dos ensinos fundamental, médio e superior é uma das mais atingidas com a perda de direitos. Apresenta os fatores que fundam a previdência e sua inserção na seguridade social. Aborda o processo de expropriação dos direitos da classe trabalhadora em decorrência das contrarreformas ao longo de governos no pós-1988 e os impactos da contrarreforma da previdência do governo Bolsonaro sobre os direitos dos professores. A análise apresenta uma abordagem histórico-crítica e foi construída por meio de pesquisa bibliográfica e documental. Considera-se que os docentes integram uma das categorias mais impactadas com a retirada de direitos: redução de salários por meio do novo cálculo, estabelecimento da idade mínima e do tempo de contribuição, assim como em aspectos relacionados à perspectiva de gênero. Palavras-Chave: política de previdência; seguridade social; contrarreforma da previdência; docentes.
A Fiocruz e sua criatura: o nascimento da fundação de apoio privado
Authors: Reis Tiago Siqueira
Published: September 2023

O presente artigo analisa a trajetória política e institucional da Fiocruz entre os anos de 1988 e 2003, quando se discutiu internamente a elaboração do novo estatuto social, especialmente a definição do novo modelo jurídico e gerencial. Para tanto, discutiremos, a partir da participação dos membros da Fiocruz durante a realização dos congressos internos da entidade, quais alternativas, projetos e escolhas foram traçados para a confecção do projeto institucional. Demonstramos como a Fiocruz se relacionou com a reforma do Estado do governo de Fernando Henrique Cardoso (1995-98) e com diferentes modelos de gestão de natureza flexível e privada. Nesse sentido, argumentamos que a criação da fundação de apoio privado faz parte do projeto institucional de flexibilização jurídica e gerencial da Fiocruz, construído coletivamente no âmbito interno, mantendo-se, assim, organicamente o público e o privado em uma só identidade.   Palavras-Chave: fundação de apoio privado; Fiocruz; modelo de gestão.