bluuebunny/crossref_metadata_2025 huggingface dataset:
ИСТОРИОГРАФИЧЕСКИЙ ОБЗОР ИССЛЕДОВАНИЙ ФОЛЬКЛОРА СЛАВЯНСКИХ НАРОДОВ В РЕСПУБЛИКЕ БАШКОРТОСТАН
Authors: Sirazhitdinova Nafisa Mindiyarovna
Published: January 2019

В Республике Башкортостан, помимо коренного народа – башкир, насчитывается свыше 100 народностей, переселившиеся на современную территорию в разное время. По переписи 2010 г. численность белорусов, марийцев, мордва, русских, татар, удмуртов, украинцев и чувашей превышает 10 тыс. человек. Из славянских народов численность русских составила 1432906, украинцев – 39875, белорусов – 11680, поляков 504 человека. Переселившиеся народы сохранили традиционный фольклор своих предков, который на новой территории наполнялся локальными особенностями.В 2020 г. в Республике Башкортостан будет проходить Всемирная Фольклориада, в рамках подготовки к которой в Государственном автономном учреждении науки «Башкирская энциклопедия» ведётся работа по теме «Разработка научно-методических основ и подготовка энциклопедии “Фольклор народов Башкортостана”». Накопленный методический опыт в организации диктует необходимость концентрации наработанных научных знаний по тематике в целях наиболее полного изучения темы и выработки критериев включения статей в энциклопедию. Поэтому в данной работе проводится историографический обзор научных трудов по фольклору славянских народов на территории Республики Башкортостан, определяются основные тенденции исследований, ведущие учёные-исследователи славянского фольклора Башкортостана, а также проводится обзор некоторых особенностей методологии изучения регионального фольклора.Цель. Обзор научных трудов по славянскому фольклору в Республике Башкортостан и обобщение основных итогов исследований по теме для дальнейшей выработки критериев включения статей в энциклопедическое издание.Метод или методология проведения работы. Научно-практическую методологию определяют методы историко-сравнительного, системного анализа материла.Результаты. Концентрация и научное обобщение региональной фольклорной информации наработанных научных знаний по тематике для наиболее полного изучения заявленной темы и выработки критериев включения статей в энциклопедию.Область применения результатов. Результаты исследования будут применены в энциклопедии «Фольклор народов Башкортостана», которая будет служить источником для дальнейших исследований и использоваться для презентации современного состояния фольклора региона во время проведения Всемирной Фольклориады в 2020 г. в Башкортостане.
ПСИХОЛОГИЧЕСКИЕ ФАКТОРЫ НЕВРОТИЗАЦИИ ЮНЫХ СПОРТСМЕНОВ-ЛУЧНИКОВ
Authors: Nafanailova Maria Semenovna , Rybalkina Valentina Viktorovna
Published: January 2019

Данная работа посвящена изучению факторов невротизации юных спортсменов-лучников.Цель. Статья посвящена актуальной в современной психологии спорта теме невротизации. Мы ставим целью выявить и описать индивидуально-психологические особенности спортсменов-лучников, препятствующих или способствующих их невротизации.Задачи. Для достижения данной цели потребовалось решение следующих задач:1. Определить уровень невротизации спортсменов-лучников;2. Изучить особенности самовосприятия, выраженность акцентуаций характера, уровень адаптивных способностей и способов преодоления трудностей в различных сферах психической деятельности у спортсменов-лучников;3. Установить взаимосвязь изученных психологических характеристик с уровнем невротизации у спортсменов-лучников.Методы проведения работы. В основу исследования легли следующие методики:1. Многоуровневый личностный опросник (МЛО) «Адаптивность», разработанный А.Г. Маклаковым и С.В. Чермяниным (1993).2. УНП – уровень невротизации – клиническая тестовая методика, предназначенная для диагностики личностных черт невротического уровня, созданный И.Б. Ласко и Б.И. Тонконогий (1974).3. Методика изучения акцентуаций личности К. Леонгарда (модификация С. Шмишека) (1970).4. Копинг-тест Лазаруса, предназначенный для определения способов преодоления трудностей в различных сферах психической деятельности (1984).5. Проективная методика «Автопортрет» служит для выявления индивидуально типологических особенностей человека, его представлений о себе, своей внешности, личности и отношения к ней Е.С. Романова и С.Ф. Потемкина (1991).Научная новизна результатов исследования определяется тем, что:1. Разработан профиль стрелков из лукана основеизученных индивидуально-психологических свойств.2. Перспективность использования полученных данных о невротизации и психопатизации спортсменов-стрелков из лука на основе учета их индивидуально-психологических свойств в учебно-тренировочном процессе.Результаты. Вся тренировочная и соревновательная деятельность юных лучников проходят на фоне сильного эмоционального напряжения, а также в условиях постоянно усиливающейся конкуренции между спортсменами.Так, уровень невротизации спортсменов-лучников колеблется от низкого и очень низкого значения – есть взаимосвязь с низким уровнем коммуникативных способностей. Что же касается психопатизации юных спортсменов, то их значения равны от неопределенного до пониженного уровня.Это говорит о том, что в рамках психологической помощи юным спортсменам одним из возможных направлений работы может быть аутотренинг, тренинги на доверие, а также сплочение спортивного коллектива.Область применения результатов. Результаты нашего исследования могут быть применимы при разработке учебных курсов для студентов-психологов, посвященных актуальным проблемам современной психологии, а также в процессе консультирования и коррекционной работы клинических и спортивных психологов с подростками по проблемам невротизации, самовосприятия себя.
ДЕТСКО-РОДИТЕЛЬСКИЕ ОТНОШЕНИЯ В МАТЕРИНСКОЙ СЕМЬЕ
Authors: Egorova Valentina Nikiforovna , Matveeva Natalia Vasilevna
Published: January 2019

В настоящее время наблюдается рост количества детей, родившихся без отца. В статье представлены результаты изучения детско-родительских отношений в неполной (материнской) семье.Целью исследования является выявление типа родительского отношения в материнской семье.Предметом данной работы являются детско-родительские отношения в материнской семье. Объектами исследования были 60 подростков и 60 одиноких матерей, проживающие в сельском районе Республики Саха (Якутия).Исследование детско-родительских отношений было проведено с помощью опросника «Поведение родителей и отношение подростков к ним» (ADOR-сокращенно, подростки о родителях, опросник родительских отношений (А.Я. Варга, В.В. Столин), методика изучения структуры интегральной индивидуальности по 120 симптомам (Т.Ф. Базылевич).Выделены предпочитаемые одинокими матерями типы взаимоотношений с детьми подросткового возраста. Обнаружено, что негативное или положительное восприятие родительских отношений в значительной мере обусловлено полом подростков: стремление матери инфантилизировать ребенка воспринимается мальчиками как негативное, девочками как позитивное. Однако различия имеются в показателях внутри представителей одного пола в зависимости от сложившейся структуры индивидуальности подростков. Матери сыновей, принадлежащих к I типологическому синдрому индивидуальности, более склонны к отвержению, чем матери мальчиков с II типологическим синдромом.Результаты исследования могут быть применены школьными психологами и социальными педагогами.
ПСИХОЛОГИЧЕСКИЕ ОСОБЕННОСТИ РАЗНЫХ ФОРМ АГРЕССИВНОГО ПОВЕДЕНИЯ У МЛАДШИХ ШКОЛЬНИКОВ
Authors: Leonteva Maria Dmitrievna , Nikolaeva Olga Nikolaevna
Published: January 2019

В статье представлены результаты исследования агрессивного поведения детей младшего школьного возраста. Целью работы является анализ психологических особенностей разных форм проявления агрессии.На первой стадии были сформированы три группы агрессивных детей с различной мотивацией агрессивного поведения: импульсивно-демонстративный тип, нормативно-инструментальный и целенаправленно-враждебный типы. Установлено, что детям с импульсивно-демонстративной формой агрессии характерна высокая тревожность и негативные отношения с родителями и сиблингами.Между тем, повышение эмоциональной компетентности посредством коррекционной программы, позволило существенно снизить уровень агрессии в этой группе. При целенаправленно-враждебном типе агрессии детям присущи низкая социальная приспособленность и негативное самоотношение. Эта форма поведения наиболее устойчива и требует длительной коррекции. Для детей с нормативно-инструментальной формой агрессия является не механизмом защиты, а своеобразной нормой поведения. Полученные выводы могут быть использованы в профессиональной деятельности педагогов, школьных психологов, социальных педагогов и других специалистов системы образования.
ЦЕННОСТИ СТУДЕНЧЕСКОЙ МОЛОДЕЖИ
Authors: Makarova Agrafena Petrovna
Published: January 2019

Ценности являясь своеобразным социальным регулятором поведения, играют важную роль в формировании личности. Они характеризуют направленность, содержание и формы выражения поведения. Ценности влияют на взгляды, позиции и модели поведения представителей общества, закрепляются в социальной и этнической идентичности.Целью работы является изучение структуры ценностей студенческой молодежи.Метод и методология проведения работы. Основу исследования образуют исследования, посвященные изучению ценностей: М. Рокича, Ш. Шварца, Л. Колберга, К. Гиллиган, Н.М. Лебедевой, В.Н. Куницыной и др.Результаты работы заключаются в том, что у современных студентов в структуре ценностей преобладающими ценности безопасности, достижения, межличностных отношений, что входят отражают в первую очередь нравственные и семейные ценности.Область применения результатов. Результаты исследования могут быть применены в профилактической, консультационной работе с молодежью.
Strategic Management Accounting Systems and Company Development Strategy
Authors: Воронова Екатерина , Voronova E.
Published: January 2019

The article deals with the relationship of strategic management accounting and company strategy. The article deals with the following methods of strategic management accounting: value chain costing, clients and competitors are considered. Attention is paid to the comparison of traditional and strategic management accounting.
Economic Interests and Professional Ethics of an Accountant
Authors: Миславская Н. , Mislavskaya N.
Published: January 2019

The article is devoted to the issues of professional ethics of an accountant, the discussion of which the majority of members of the professional economic community considers no more than a fashionable trend, and therefore the importance and role of moral attitudes in the accountant profession remain unclear and undervalued. The content of the article is aimed at justifying the significance of the problems resulting from this situation and attracting the attention of the professional community to this topic.
Multidisciplinary Management of Maxillary Regional Odontodysplasia
Authors: Jeffery Shahrzad , Brock Gareth R , Harrison Jayne E , Butterworth Chris J
Published: January 2019

This case report describes the multidisciplinary clinical management of a male patient, diagnosed at the age of 7, with Regional Odontodysplasia of the right maxilla. Following fixed orthodontic treatment to align his teeth, extraction of malformed teeth and subsequent bone grafting, the patient was successfully rehabilitated with implant-supported bridgework of a hybrid design to replace the teeth in the right maxillary quadrant. Clinical steps, as well as the complexities of this particular case, will be described.

CPD/Clinical Relevance: This case highlights the need for a multidisciplinary team approach to provide comprehensive care for patients with complex dental anomalies.
Evaluation of Damage Severity of Tea Plants Using Electronic Nose
Authors: Sun Yubing , Sun Yubing , Wang Jun , Cheng Shaoming , Wang Yongwei , Wang Jun , Cheng Shaoming , Wang Yongwei
Published: January 2019

Abstract.

In this study, an electronic nose (E-nose) was used to evaluate the damage severity of tea plants, and a new evaluation index (mass loss) was introduced to reflect damage severity. Gas chromatography-mass spectrometer (GC-MS) was employed for proving the potential of the E-nose to detect tea plants with different damage severities. The number of pests attacking tea plants and the time under attack are two traditional evaluation indexes that are widely applied. The prediction performance of mass loss was compared with the number of pests and time under attack based on partial least squares regression (PLSR) according to the correlation coefficient (R2) and root mean square error (RMSE), and the results showed that the prediction performance of mass loss was better than that of the other two indexes. Three regression algorithms, namely PLSR, extreme learning machine for regression (ELMR), and support vector regression (SVR), were applied to predict mass loss, and their performances were compared. The results indicated that these three algorithms all had good performances, and SVR was the best. It could be concluded that E-nose is a feasible technique for evaluating the damage severity of tea plants, and mass loss is an appropriate evaluation index for damage severity. Keywords: Damage severity, Electronic nose, Mass loss, Regression algorithm.
Moisture Content Classification of Soil and Stalk Residue Samples from Spectral Data Using Machine Learning
Authors: Hamidisepehr Ali , Hamidisepehr Ali , Sama Michael P. , Sama Michael P.
Published: January 2019

Abstract.

Remotely sensed spectral data are commonly used to quantify material properties in agricultural applications. Typically, a few distinct bands are selected and formulated into a reflectance index. Machine learning presents an alternative approach for quantifying material properties from spectral data due to the ease at which it can be used to process large datasets. This study aimed to test several commercially available machine learning algorithms using spectral data collected from moisture-controlled silt-loam soil and wheat stalk residue samples. The spectral data used in this analysis were previously used to develop a normalized difference water index (NDWI) for remotely quantifying the moisture content of agricultural background materials by selecting a pair of narrow-band wavelengths. However, results showed mixed performance for index-based processing. In this study, raw spectral data were preprocessed using partial least squares (PLS) regression to optimize the number of input components. The PLS components were fed into 20 different machine learning algorithms available in MATLAB, and the best two performing methods were compared to the index-based method. Cubic support vector machine (SVM) and ensemble bagged trees methods produced the highest composite prediction accuracies of 96% and 93%, respectively, for silt-loam soil samples and 86% and 93%, respectively, for wheat stalk residue samples. Prediction accuracy using the index-based method was 86% for silt-loam soil and 30% for wheat stalk residue. A potential limitation of both machine learning methods was the discrete classification of moisture content rather than the continuous output of the index-based method. However, the substantial improvement in prediction accuracy of individual samples likely outweighs concerns with limited precision. Keywords: Machine Learning, Normalized difference water index, Remote sensing, Soil moisture, Spectroscopy.
Stress Relaxation of Apples at Different Deformation Velocities and Temperatures
Authors: Stropek Zbigniew , Stropek Zbigniew , Golacki Krzysztof , Golacki Krzysztof
Published: January 2019

ABSTRACT. Stress relaxation tests on apples (‘Beni Shogun’ variety) were performed at different velocities in the range of 0.0002 to 1 m s-1 and at three temperatures (2°C, 10°C, and 20°C). The generalized Maxwell model was used to describe the experimental stress relaxation curves. The two relaxation times of the model decreased with an increase in the deformation velocity. The relaxation times were related to the processes of gas and liquid flows in the intercellular spaces. This research showed the critical velocity associated with the weakness of the apple structure to lie between deformation velocities of 0.0002 and 0.002 m s-1, where a rapid decrease in the two relaxation times occurred. An increase in the peak force response with increasing deformation velocity showed the viscoelastic behavior of apple flesh. The equilibrium modulus describing the material condition after deformation was much larger under the quasi-static loading condition than the impact loading condition at all deformation velocities. The temperature did not seem to affect the Maxwell model parameters and peak force response for all deformation velocities under both loading conditions. Keywords: Apple, Generalized Maxwell model, Impact loading, Quasi-static loading, Stress relaxation, Viscoelasticity.
Georges Perec instrucciones de uso: Lecturas perecquianas en la docencia de arquitectura
Authors: Díaz García Asunción
Published: January 2019

Múltiples caminos pueden conducir la dirección y el sentido de la experiencia lectora de un arquitecto en la obra literaria del escritor francés Georges Perec. Transcurridos cuarenta años desde que se publicase la primera edición de su novela La Vie mode d´emploi en 1978, se puede afirmar que tanto esta como el resto de su obra constituye un valioso patrimonio intelectual contemporáneo para muy diversas disciplinas. La recepción póstuma de su literatura ha desvelado ser muy fecunda en el campo de las artes plásticas y visuales, pero dada la proyección significativa y simbólica que el espacio adquiere en la construcción de sus textos, es en la arquitectura donde esta se manifiesta de un modo más instrumentalizado. El presente artículo, apoyándose en teorías literarias, abordará la complejidad de dicho espacio narrativo descubriendo los mecanismos empleados para su construcción a través de la división del mismo en tres dimensiones: referente, texto e historia. Un trinomio al que se suplementará la dimensión de la propia lectura, tratando así de establecer las claves del porqué la obra de Perec ejerce tal atracción sobre determinados arquitectos hasta el punto de ser utilizada en su faceta como docentes, y que se manifiesta en experiencias llevadas a cabo en torno a modos de ver, procesos de ideación y adquisición de conocimiento en escuelas de arquitectura de París, Barcelona y Nueva York, bajo la dirección de los arquitectos Vincen Cornu, Enric Miralles y Enrique Walker respectivamente.
Red de distribución de agua del mar: Ciudad del Cabo
Authors: Pignatelli Pedro
Published: January 2019

Se propone un proyecto de Red de Abastecimiento de Agua de Mar en Ciudad del Cabo (Sudáfrica) como suministro en paralelo y coexistente con la red general convencional de abastecimiento de agua dulce, de forma que se pueda utilizar agua de mar en todos los procesos domésticos e industriales que no requieran necesariamente de agua dulce. De esta forma se minimiza el consumo de agua dulce y se combaten las carencias hidrológicas así como la amenaza de un inminente corte de agua (día cero) estimado para mayo de 2018. Más del 50% de la población mundial vive cerca de la costa. Se trata generalmente de la zona más castigada por las sequías, lejos de pantanos, montañas y nacimiento de ríos, donde a menudo los acuíferos están también afectados por procesos de salinización. Esta propuesta, desarrollada en Ciudad del Cabo por ser la primera gran urbe mundial en llegar a una situación límite de sequía, podría ser aplicada a otras ciudades costeras que ya se encuentran seriamente amenazadas por el mismo problema. Aprovechando de esta forma un recurso prácticamente ilimitado como es el agua de mar, que constituye el 97% del agua del planeta. Las grandes sequías, pronosticadas por científicos desde hace años, son una consecuencia del cambio climático y no deberían ser contrarrestadas por industrias no sostenibles como las desalinizadoras (tan extendidas por los litorales mundiales) que no hacen sino agravar más el problema con altísimos consumos de energía, emisiones de CO2 y producción de residuos como la salmuera (vertida de nuevo al mar con el consiguiente impacto negativo en el ecosistema marino). El consumo medio de agua por habitante y día, estudiado en España por el Instituto Nacional de Estadística, es de 137 litros (en otros países aún mayor), de los cuales solo nos bebemos 2 litros. De los otros 135 litros de agua restantes se estima que 90 de ellos podrían ser de agua de mar aumentando además la calidad de vida del usuario con su utilización. El coste de ejecución de una red de abastecimiento de agua de mar se amortizaría con el coste de instalación y funcionamiento de desalinizadoras de 10 años. Esta reducción del consumo doméstico de agua dulce en la costa podría asegurar y dotar de mayor calidad a la demanda de agua potable, reduciendo las enfermedades y las amenazas de conflicto entre territorios.
New sealand. Google Micronation
Authors: Castellano Vidalle Ana , Maldonado Suarez Covadonga
Published: January 2019

New Sealand, closely related to the concept of micronation, was born as a dream of freedom, an experiment that idealizes the future but does not want to stop working to meet the expectations of that admired future. Like any googie of its own, with its feet on the ground and looking at the sky, all the ingredients that will form part of this experiment, which takes place on a naval defence platform abandoned about 20km from the English coast, are carefully chosen. Then, born from a collection of our concerns and interests, both as future architects and as people, one by one were emerging the unique characters, already mature and far from being simple concerns begin to colonize the place and end up owning the experiment. In this context, architecture is a container and content, an ecology that facilitates interactions between people, technologies, machines, nature, art, music, colours, flavours, dreams and nightmares, etc., all of which are disordered and harmonised from the subjectivity of time. This gives each personality the capacity to judge the suitability of the designs, which far from being static, become an anonymous poem made by all and yet to be made, which is perfected in time thanks to the modifications and contributions of each inhabitant. And this poem, this architecture in which they coexist, turns out to be the point where people converge and the community emerges, the nexus of union of such disparate identities that with discrepancies and affinities, work in collaboration so that this community is the best version of itself, and from there lay the foundations of a future that admires progress and trusts technology and advances the role of providers of well-being and strength, which is in a way the same future that the googies dreamed of and never arrived. The world is hopelessly broken, but it is also so big and so full of people that it would be wearisome, and despite any effort, also impossible to put it back together. In this circumstance the important thing is not the discovery of these fragments, but what we each do with them, because in part that is what defines us as people.
Art Education in the Age of Metrics. A critical exhibition about how we teach and learn art under neoliberal conditions
Authors: Brasó Emma
Published: January 2019

The higher education sector in the United Kingdom finds itself immersed in a data culture that evaluates every aspect of the university life according to a metrical paradigm. Art education, an area with its own teaching and learning characteristics, is particularly incompatible with a model that favours efficiency, productivity and success over all other aspects. In this essay I describe an exhibition, Art Education in the Age of Metrics, which took place in 2017 at the campus gallery of a specialist university located in the town of Canterbury. This was a curatorial project that tried not only to represent the difficulties of art education in the current climate, but that by engaging the university community—particularly students— in the process of organizing the exhibition, tried to actively intervene in the debates on the impact of this neoliberal model in how we teach and learn art today.
laSIA: intersecciones para la investigación artística basada en la práctica
Authors: Linaza Vivanco Veva , Sixto Cesteros Rita
Published: January 2019

laSIA es un equipo de investigación de la Facultad de Bellas Artes de la Universidad del País Vasco (EHU). Comenzó su trayectoria en el año 2016 bajo el epígrafe El lugar del sujeto en la investigación artística basada en la práctica. Este artículo relata el recorrido del grupo dando cuenta de las actividades realizadas hasta la fecha. Su trabajo intenta explorar la dimensión investigadora de la práctica artística, asumiendo la compleja relación entre práctica artística y universidad. Por ello se sitúa en las intersecciones que encuentra en estos dos ámbitos, y es ahí donde tienen su inicio un seminario, unas jornadas, una exposición y una página web; como lugares temporales donde cruzar recorridos. Se apoya argumentalmente en escritos de Roland Barthes y encuentra en los conceptos desarrollados por Donna Haraway y Rosi Braidotti (“testigo modesto”, “estilo cognitivo empático” y “resistencia”, fundamentalmente) los apoyos necesarios para trazar un lugar donde el sujeto/artista puede actuar. El artículo contiene un capítulo en el que se reproduce una conversación vía email entre las autoras; en él se permite a la escritura, como proceso de redefinición de los sujetos, comportarse de un modo más vivencial que académico.
Un nuevo parásito. El caso Candela a través del proyecto Arte de la Primera Mitad del s. XXI
Authors: Gámez Couso Iria , Monmeneu González Mónica , Ruiz Pino África
Published: January 2019

Reinventando algunas de las ideas clave de la historia del comisariado, Candela surge como institución de lo que ellas mismas denominan comensariado en el contexto del Máster en Historia del Arte Contemporáneo y Cultura Visual impartido en el MNCARS. Mediante acciones como Arte de la Primera Mitad del s. XX1 pretenden subvertir los modos de acercarse al arte, el espacio y la arquitectura, así como el modo de existir dentro de la institución a través de lo que podemos considerar prácticas parasitarias.
Habitantes Paisajistas. Living Landscape | Contextos locales-procesos comunes
Authors: López Fernández Virginia
Published: January 2019

Habitantes Paisajistas es una herramienta y metodología de trabajo: utilizar el acto de caminar como forma de aproximación e interpretación del paisaje. Cada año propone un tema relevante en torno al cual activar procesos de reflexión, creación y aprendizajes colectivos, integrando en la práctica artística diferentes saberes y disciplinas. Un proyecto artístico de Virginia López, que ha iniciado su desarrollo en el 2015 dentro del marco del proyecto PACA_Proyectos Artísticos Casa Antonino: un artist run space auto-gestionado en la zona periurbana y rural de Gijón (Asturias) desde el que la artista propone experiencias de formación, creación y experimentación artística contemporánea, de manera que la práctica e investigación artística, además de tener una valencia estética y poética, generen nuevas vías de interpretación y de conocimiento del territorio en el que operan, a través de valores culturales, ambientales y sociales. Habitantes Paisajistas se realiza en colaboración con el museo arqueológico Villa Romana de Veranes, en el intento de acercar nuevos públicos y en particular la comunidad local a la institución a través de nuevas prácticas donde lo educativo, lo experiencial y lo artístico se relacionan con la memoria de nuestros paisajes cotidianos, favoreciendo lazos afectivos e intelectuales. En este texto se describen metodologías y experiencias realizadas, contexto local de desarrollo, referencias y contradicciones surgidas en el camino.
Influence of progesterone on functional activity of neutrophils in threatening preterm labor
Authors: Dziadzichkina V. , Radeckaya L.
Published: January 2019

Aim of the study. To assess the influence of exogenous progesterone on the functional activity of neutrophils in patients, whose pregnancies proceeded with clinical signs of threatened abortion. Materials and methods. The material used for the study were peripheral blood neutrophils of 32 women, who were hospitalized with a diagnosis of "threatening premature labor" in the term of 22-34 weeks and whose pregnancies later ended in spontaneous preterm (group 1, 10 patients) and term (group 2, 22 patients) birth. Women of 1st and 2nd groups were comparable in age, gestational age and serum concentration of endogenous progesterone. The study was conducted in vitro. Neutrophils were isolated by settling for NBT-test and phagocytosis reaction, and by centrifugation on a double density gradient of ficoll-verografin in order to assess the formation of neutrophil extracellular traps. Neutrophils were added to a suspension of exogenous progesterone at concentrations of 10 ng/ml, 20 ng/ml, 100 ng/ml. The oxidation activity of neutrophils was measured in the spontaneous and stimulated (with Staphylococcus aureus at a concentration of 1×108 bacterial cells in 1 ml) types of NBT-test with microscopic evaluation of the results. The ability of neutrophils to form extracellular traps was evaluated in spontaneous and stimulated (with Staphylococcus aureus at a concentration of 1×108 bacterial cells in 1 ml) types of the test using color dye Hoechst 33342, followed by fluorescent microscopy. Results. Progesterone (10 ng/ml) significantly decreased spontaneous neutrophil oxidative activity [17.0% (12.0-26.0%) and 7.0% (4.0-10.0%), p<0.05] in patients of group 1, but not in patients of group 2. There was no effect of progesterone at studied concentrations on stimulated neutrophil oxidative activity in women of groups 1 and 2. When 20 ng/ml progesterone was added there was a decrease in neutrophil phagocytic index in patients of group 2 [66% (55-77%) and 51% (40-69%), p<0.05]. Progesterone (100 ng/ml) caused an increase in spontaneous NET-forming function in both groups and had no effect on stimulated function. Conclusions. Progesterone is able to provide various immunomodulatory effects on neutrophils of patients, whose pregnancies ended in preterm and term birth. Exogenous progesterone is able to provide various immunomodulatory effects on neutrophils of patients, whose pregnancies ended in preterm and term birth. It reduced the increased spontaneous oxidative activity of neutrophils in women with adverse pregnancy outcomes and lowered phagocytic number in patients with favorable pregnancy outcome. This drug also stimulated spontaneous NET-forming function of the cells, regardless of the pregnancy outcome.
Expression of androgen receptor and C-Kit (CD117) in triple negative breast cancer
Authors: Krylov A. , Krylov Y. , Yanchanka U.
Published: January 2019

Expression was assessed by immunohistochemistry for the androgen receptor (AR) and С-Kit (CD117) in the cells of the triple negativnogo breast cancer. Of the 110 cases studied by us triple nega-tive breast cancer AR expression was detected in 30%, С-Kit (CD117) in 41.8%. Determination of androgen receptors and С-Kit (CD117) breast cancer cell immunohistochemical diagnostic method is a valuable element for subsequent selection of the target individual genomes or immunotherapy TNBC.
BIOMECHANICAL ASSESSMENT OF SPINE DEFORMITIES IN BEKHTEREV’S DISEASE
Authors: Gladkov Aleksandr Vjacheslavovich , Rerikh Viktor Viktorovich
Published: January 2019

Objective. To analyze the dependence of the spine shape and orientation in a sagittal plane on localization of a flexion deformity associated with Bekhterev’s disease, and the outcomes of surgical deformity correction. Material and Methods. The kinematic analysis of sagittal plane spondylograms of 44 patients (43 men and 1 woman, aged 21 to 49 years) with Bekhterev’s disease before and after surgery was performed basing on author’s classification of kyphotic deformities. Illness duration was 7 to 22 years. Results. One-level correction vertebrectomy caused the increase of lordosis at two or three levels in 50 % of cases. Correction vertebrectomy for flat lumbar kyphosis resulted in normalization of all biomechanical spine parameters characterizing its shape and sagittal orientation in 100 % of cases. Lumbar vertebrectomy for flexion deformity in the thoracic spine normalized sagittal position of vertebrae only in isolated segments. Cosmetic hyperkyphosis remained, though the trunk orthostatic position had been restored. Similar results were recorded in the group with multilevel deformities. Lost of correction at vertebrectomy level and progression of flexible deformity above vertebrectomy were not revealed. Kyphotic deformity formation (ranged 16.0° to 32.0°) at the segments caudal to vertebrectomy was observed in 10 % of cases. Conclusion. Flexion deformity localization in the spine determines the condition of its further progression in many respects. Correction lumbar vertebrectomy while reconstructing orthostatic trunk position does not always result in complete normalization of vertebra sagittal position in anchylosis spine.
POTENTIALITIES OF HIGH INFORMATIVE STUDIES TO ESTIMATE OBJECTIVELY LUMBAR VERTEBRAL FUSION WITH TITANIUM IMPLANTS
Authors: Dotsenko Vladimir Valentinovich , Remizov N. V. , Vovkogon V. B. , Kruglov I. A. , Remizov A. N. , Dotsenko P. V.
Published: January 2019

Objective. Using high informative studies to analyze osteointegration processes in the presence of titanium implants and postoperative changes in the spinal canal after its decompression. Material and Methods. A total of 362 patients (221 female and 141 male at the age of 11 to 78 years)were operated on through extraperitoneal mini-approach to anterior spine at L2–S1 level. Postoperatively all patients underwent standard radiography. High informative diagnosis methods (CT, MRI, spiral CT) were applied to 38 patients. In 38 patients data of high informative diagnostic methods were compared with radiographic findings and clinical manifestations. Results. Complete disappearance of the pain syndrome within one year after surgery was observed in 24 patients. The pain has remitted in 14 patients. Three patients with osteoporosis had a delayed bone fusion formation. They still had a pain more than one year after surgery. Conclusion. Radiodiagnostics after the ALIF surgery is performed to evaluate bone fusion, decompression completeness, and implant position. CT and spiral CT are more useful for the evaluation of interbody fusion, while MRI – for the qualitative evaluation of the spinal canal reconstruction.
SCHEUERMANN’S DISEASE INHERITANCE MECHANISM
Authors: Zaidman Alla Mikhailovna , Fomichev Nikolay Gavrilovich , Kalashnikova Elena Vladimirovna , Aksenovich Tatyana Iosifovna
Published: January 2019

Objective. To analyse the mechanism of Sheuermann’s disease genetic determination in a representative samples of pedigrees and to identify its hereditary phenotypic signs. Material and Methods. Patients with Scheuermann’s disease (90 probands and 385 relatives of 1st–3rd relation degree) were examined using clinical-genetical, optical topographical, and radiological methods. Results. Scheuermann’s disease incidence among closest relatives of the probands was 0.143 in sisters (n = 21), 0.476 in brothers (n = 21), 0.250 in mothers (n = 84), and 0.743 in fathers (n = 35). These values significantly exceed the incidence in general population, what confirms a familial aggregation of Scheuermann’s disease. The incidence was higher in brothers and fathers of the probands than in their sisters and mothers, respectively. Both parents have been examined in 32 probands. Out of these families 5 had both parents unaffected, 22 families had affected fathers, 4 families had affected mothers, and 1 family had both parents affected. This also indicates that men are more predisposed to Scheuermann’s disease than women. Conclusion. Segregation analysis has shown that Scheuermann’s disease is a genetically dependent pathology inherited by autosomal dominant type and controlled by major gene with full pentrance in boys and 50 % penetrance in girls.
TREATMENT FOR COMPLICATED AND UNCOMPLICATED SPINE INJURIES IN MULTITRAUMA PATIENTS
Authors: Krylov Vladimir Viktorovich , Grin Anatoly Andreyevich , Ioffe Yury Solomonovich , Kaznacheev Viktor Mikhailovich , Nikolaev Nikolay Nikolayevich , Nekrasov Mikhail Alekseyevich
Published: January 2019

Objective. To determine treatment tactics for spine and spinal cord injuries in multitrauma patients. Material and Methods. 184 patients with spine and spinal cord injuries combined with multiple traumas were treated at Sklifosovsky Clinical and Research Institute for Emergency Medicine in 2000–2003, out of them 141 patients underwent surgical treatment. Diagnostic algorithm included general and neurologic examinations, ultrasound studies of the abdominal and pleural cavities, radiography of the skull, pelvic, ribs, injured extremities and all spine levels, and spine myelography and CT. Patients were examined by resuscitator, neurosurgeon, traumatologist and surgeon. Hemodynamic and arterial blood characteristics were monitored in critically ill patients. To assess the severity of multiple trauma the ISS scoring system was used. Results. Single-stage operation in the spine and bones of the skeleton was performed in 13 patients, first-stage spine surgery (preceding another intervention) – in 39 patients, second-stage spine surgery – in 24 patients, and 65 patients underwent a spine surgery alone. Neurologic status improved in 60 patients. Total lethality was 22 % and postoperative one – 14 %. Conclusion. Direct relation between surgery outcome and severity of multiple trauma was reveled. Application of upto- date transpedicular and laminar fixation techniques, and halo-apparatus provides the possibility to perform twostage surgery for complicated unstable vertebral fractures in patients with severe trauma.
Anaplastic Carcinoma Thyroid in a Young Child – an Extremely Rare Occurrence
Authors: Sharma Suresh Chandra , Sakthivel Pirabu , Raveendran Sarath , Singh Chirom Amit , Nakra Tripti , Agarwal Shipra
Published: January 2019

Anaplastic thyroid carcinoma (ATC), one of the most aggressive malignancies, is extremely rare in childhood. We present a case of 5-yearold child who presented with rapidly progressing thyroid swelling and stridor, for which she underwent emergency tracheostomy and biopsy. Histopathological features were suggestive of ATC and the patient died within two months after diagnosis. ATC, though very rare in childhood, should be kept in the differential diagnoses of rapidly enlarging neck masses in children. To the best of our knowledge, this is the youngest case of ATC reported in literature.
Long-Term, Targeted Delivery of GDNF from Encapsulated Cells Is Neuroprotective and Reduces Seizures in the Pilocarpine Model of Epilepsy
Authors: Paolone Giovanna , Falcicchia Chiara , Lovisari Francesca , Kokaia Merab , Bell William J. , Fradet Tracie , Barbieri Mario , Wahlberg Lars U. , Emerich Dwaine F. , Simonato Michele
Published: January 2019

Neurotrophic factors are candidates for treating epilepsy, but their development has been hampered by difficulties in achieving stable and targeted delivery of efficacious concentrations within the desired brain region. We have developed an encapsulated cell technology that overcomes these obstacles by providing a targeted, continuous,de novosynthesized source of high levels of neurotrophic molecules from human clonal ARPE-19 cells encapsulated into hollow fiber membranes. Here we illustrate the potential of this approach for delivering glial cell line-derived neurotrophic factor (GDNF) directly to the hippocampus of epileptic rats.In vivostudies demonstrated that bilateral intrahippocampal implants continued to secrete GDNF that produced high hippocampal GDNF tissue levels in a long-term manner. Identical implants robustly reduced seizure frequency in the pilocarpine model. Seizures were reduced rapidly, and this effect increased in magnitude over 3 months, ultimately leading to a reduction of seizures by 93%. This effect persisted even after device removal, suggesting potential disease-modifying benefits. Importantly, seizure reduction was associated with normalized changes in anxiety and improved cognitive performance. Immunohistochemical analyses revealed that the neurological benefits of GDNF were associated with the normalization of anatomical alterations accompanying chronic epilepsy, including hippocampal atrophy, cell degeneration, loss of parvalbumin-positive interneurons, and abnormal neurogenesis. These effects were associated with the activation of GDNF receptors. All in all, these results support the concept that the implantation of encapsulated GDNF-secreting cells can deliver GDNF in a sustained, targeted, and efficacious manner, paving the way for continuing preclinical evaluation and eventual clinical translation of this approach for epilepsy.

SIGNIFICANCE STATEMENTEpilepsy is one of the most common neurological conditions, affecting millions of individuals of all ages. These patients experience debilitating seizures that frequently increase over time and can associate with significant cognitive decline and psychiatric disorders that are generally poorly controlled by pharmacotherapy. We have developed a clinically validated, implantable cell encapsulation system that delivers high and consistent levels of GDNF directly to the brain. In epileptic animals, this system produced a progressive and permanent reduction (>90%) in seizure frequency. These benefits were accompanied by improvements in cognitive and anxiolytic behavior and the normalization of changes in CNS anatomy that underlie chronic epilepsy. Together, these data suggest a novel means of tackling the frequently intractable neurological consequences of this devastating disorder.
Roles of the HOXA10 gene during castrate-resistant prostate cancer progression
Authors: Long Zhi , Li Yinan , Gan Yu , Zhao Dongyu , Wang Guangyu , Xie Ning , Lovnicki Jessica M , Fazli Ladan , Cao Qi , Chen Kaifu , Dong Xuesen
Published: January 2019

Homeobox A10 (HOXA10) is an important transcription factor that regulates the development of the prostate gland. However, it remains unknown whether it modulates prostate cancer (PCa) progression into castrate-resistant stages. In this study, we have applied RNAin situhybridization assays to demonstrate that downregulation of HOXA10 expression is associated with castrate-resistant PCa. These findings are supported by public RNA-seq data showing that reduced HOXA10 expression is correlated with poor patient survival. We show that HOXA10 suppresses PCa cell proliferation, anchorage colony formation and xenograft growth independent to androgens. Using AmpliSeq transcriptome sequencing, we have found that gene groups associated with lipid metabolism and androgen receptor (AR) signaling are enriched in the HOXA10 transcriptome. Furthermore, we demonstrate that HOXA10 suppresses the transcription of the fatty acid synthase (FASN) gene by forming a protein complex with AR and prevents AR recruitment to the FASN gene promoter. These results lead us to conclude that downregulation of HOXA10 gene expression may enhance lipogenesis to promote PCa cell growth and tumor progression to castrate-resistant stage.
Inhibition of TPPP3 attenuates β-catenin/NF-κB/COX-2 signaling in endometrial stromal cells and impairs decidualization
Authors: Shukla Vinay , Kaushal Jyoti Bala , Sankhwar Pushplata , Manohar Murli , Dwivedi Anila
Published: January 2019

Embryo implantation and decidualization are critical events that occur during early pregnancy. Decidualization is synchronized by the crosstalk of progesterone and the cAMP signaling pathway. Previously, we confirmed the role of TPPP3 during embryo implantation in mice, but the underlying role and mechanism of TPPP3 in decidualization has not yet been understood. The current study was aimed to investigate the role of TPPP3 in decidualization in vivo and in vitro. For in vivo experiments, decidual reaction was artificially induced in the uteri of BALB/c mice. TPPP3 was found to be highly expressed during decidualization, whereas in the uteri receiving TPPP3 siRNA, decidualization was suppressed and the expression of β-catenin and decidual marker prolactin was reduced. In human endometrium, TPPP3 protein was found to be predominantly expressed in the mid-secretory phase (LH+7). In the primary culture of human endometrial stromal cells (hESCs), TPPP3 siRNA knockdown inhibited stromal-to-decidual cell transition and decreased the expression of the decidualization markers prolactin and IGFBP-1. Immunofluorescence and immunoblotting experiments revealed that TPPP3 siRNA knockdown suppressed the expression of β-catenin, NF-κB and COX-2 in hESCs during decidualization. TPPP3 inhibition also decreased NF-kB nuclear accumulation in hESCs and suppressed NF-κB transcriptional promoter activity. COX-2 expression was significantly decreased in the presence of a selective NF-kB inhibitor (QNZ) implicating that NF-kB is involved in COX-2 expression in hESCs undergoing decidualization. TUNEL assay and FACS analysis revealed that TPPP3 knockdown induced apoptosis and caused loss of mitochondrial membrane potential in hESCs. The study suggested that TPPP3 plays a significant role in decidualization and its inhibition leads to the suppression of β-catenin/NF-κB/COX-2 signaling along with the induction of mitochondria-dependent apoptosis.
A New Arterial Cannulation Technique: Arterial Cannulation through Aortic Anastomosis (“Kaplan” Technique)
Authors: Kaplan Mehmet , Karaagac Anil , Yesilkaya Mehmet Inanç , Can Tolga , Pocan Yusuf Kagan , Aydogan Hakk
Published: January 2019

We performed Bentall procedure on a 65-year-old male patient. Cardiopulmonary bypass was initiated via cannulation of the aneurysmatic segment of the aorta. Distal anastomosis was performed with the open technique under deep hypothermic circulatory arrest at 18°C.
We performed arterial recannulation through the anastomosis with a new technique, and cardiopulmonary bypass was reestablished. Cardiopulmonary bypass was terminated after rewarming and de-airing phases, and decannulation was performed without any problems.
By this technique, the patient had no additional incisions for arterial cannulation, and there were no additional cannulation sutures left on the patient’s arterial tree or the valved conduit.
Plokštinis kapinynas Kleiner Kaup: tyrimai ir radiniai
Authors: Кулаков Владимир
Published: January 2019

Комплекс памятников археологии, включающий ряд селищ, открытое торгово-ремесленное поселение и связанный с ним курганно-грунтовой могильник, а также не менее двух грунтовых могильников V и XI вв. (Kulakov, 2005, S. 55), расположен в северной части полуострова Самбия, в 3 км к югу от центра г. Зеленоградска, на северной окраине пос. Моховое (ehem. Wiskiauten, широта: 54,923 8889°, долгота: 20,480 5556°). Как и остальные торгово-ремесленные пункты эпохи викингов, известные в Балтийском макрорегионе, Кауп занимает место на краю прусской племенной территории. Этот комплекс памятников археологии находится в 23 км к северу от г. Калининграда, на северном побережье полуострова Самбия, у юго-западной оконечности Куршской косы. В 3 км к югу от г. Зеленоградска, расположено лесное урочище (к настоящему времени лес имеет в плане форму неправильного ромба – рис. 1). В этой части полуострова в результате многовековой распашки сохранились лишь незначительные фрагменты лесного покрова. В таком небольшом лесу (преимущественно – лиственном), носящем историческое название «Кауп», на вершине камовой возвышенности, достигающей от уровня вод Балтийского моря 11 м, находится курганно-грунтовой могильник, со времени своего открытия (3 августа 1865 г.) именуемый также «Кауп». Этот самый известный в исторической Пруссии памятник археологии был открыт премьер-лейтенантом Вульффом. Этот любознательный гренадерский офицер обратил внимание на то, что из обрыва у дороги Wosegau–Mülsen (ныне – Вишневка-Холмы) высыпаются человеческие и конские кости, наконечники копий, ножницы. Данные предметы являлись, по мнению премьер-лейтенанта Вульффа, инвентарём из могил литовских воинов (жертвы битвы при Рудау 1370 г.?) (Wulff, 1865, S. 641–646). [...]