bluuebunny/crossref_metadata_2025 huggingface dataset:
Type specimens of Coenosiini (Diptera, Muscidae) deposited in the Museum für Naturkunde, Humboldt-Universität zu Berlin (Berlin, Germany)
Authors: COURI MÁRCIA S. , PONT ADRIAN C.
Published: May 2020

The Museum für Naturkunde of the Humboldt-Universität zu Berlin houses one of the most important and extensive collections of Muscidae (Diptera) in Europe as it includes more than 700 species described by Paul Stein and many others described by two other European dipterists, F. H. Loew and T. Becker. The relevance of the collection is even greater due to the excellent geographic coverage of this material. In this paper, we give a morphological and taxonomic revision of the 114 types of Coenosiini deposited in this collection. Differential diagnoses, notes on the types and photographs of some of them (habitus and labels) are provided.
North Atlantic Oscillation Effect on Interannual Variability in Winter Precipitation over the Gulf Stream
Authors: Sun Yue , Liu Jing-Wu , Xie Shang-Ping
Published: May 2020

In winter, the warm water of the Gulf Stream anchors a salient precipitation band. Previous studies suggested a close relationship between the sea surface temperature (SST) front and the precipitation band through sea level pressure (SLP) adjustment. This study uses 17 years of high-resolution precipitation observations to reveal that the variation in wintertime precipitation over the Gulf Stream is related to the North Atlantic Oscillation (NAO) at the interannual time scale. The moisture budget analysis shows that the climatological precipitation band is supported by the large evaporation from the Florida Current, mean flow, and synoptic moisture convergence within the boundary layer, with a negative contribution from mean-flow moisture advection by the prevailing northwesterlies. For interannual variability, by contrast, the negative contribution of mean-flow moisture advection significantly decreases due to anomalous southeasterlies west of the intensified Azores high at the positive NAO phase. The contributions from mean-flow moisture advection and mean and synoptic convergence vary greatly along the Gulf Stream. In addition, mean-flow and synoptic moisture convergences positively contribute to the precipitation band both in climatology and at the interannual time scale, indicative of a positive feedback between precipitation and boundary layer convergence. Our analysis suggests that the SLP adjustment mechanism across the SST front is still at work in interannual variability, and the variation of synoptic activities over the Gulf Stream plays an important role in modulating the frontal precipitation. By relating the frontal precipitation to the NAO, this study bridges small-scale air–sea interaction and large-scale atmospheric circulation.
Predicting Daily Mean Wind Speed in Europe Weeks ahead from MJO Status
Authors: Lledó Llorenç , Doblas-Reyes Francisco J.
Published: May 2020

The Madden–Julian oscillation (MJO), a prominent feature of the tropical atmospheric circulation at subseasonal time scales, is known to modulate atmospheric variability in the Euro-Atlantic region. However, current subseasonal prediction systems fail to accurately reproduce the physical processes involved in these teleconnection mechanisms. This paper explores the observed impact of strong MJO events on surface wind speed over Europe. It is found that some MJO phases are accompanied by strong wind anomalies in Europe. After showing that this teleconnective mechanism is not present in the predictions of the ECMWF monthly forecasting system, a methodology to reconstruct forecasts of daily mean wind speed in the continent weeks ahead is proposed. This method combines MJO forecasts from the S2S project database and the observed teleconnection impacts in the historical records. Although it is found that strong MJO events cannot be skillfully predicted more than 10 days ahead with current prediction systems, a theoretical experiment shows that this method can effectively transform a dynamical MJO forecast into a probabilistic wind speed prediction in Europe.
Leader–follower formation source seeking control of multiple ships using sliding mode active disturbance rejection observer
Authors: Yuan Zhicheng , Wu Benchao , He Jiayi , Fu Xingchen , Chen Hua
Published: May 2020

In this paper, the control of multiple ships for unknown scalar field source seeking problem with unknown external disturbances is considered. The sliding mode active disturbance rejection observers are designed first to converge to fixed multiple of the unknown external disturbances in finite time, respectively, and a least square method is adopted to estimate the gradient of the unknown scalar field at the position of the leading ship. Second, the surge, sway and angle velocity of the leading ship can converge to the virtual kinematic controllers through the input control of the dynamic controllers using force and torque in finite time. Third, the virtual controllers and dynamic controllers of the following ships are developed to urge the following ships to accomplish the source seeking problem from the perspective of dynamics. Finally, theoretical proofs and simulations are provided to prove the effectiveness of the strategy proposed.
Community-Based Health Promotion in Occupational Therapy: Assess Before You Assess
Authors: Janssen Sclinda L. , Klug Marilyn , Johnson Gusaas Sara , Schmiesing April , Nelson-Deering Danielle , Pratt Haley , Lamborn Breann
Published: May 2020

In the United States, the role of occupational therapy (OT) in provision of community-based health promotion is supported well in the literature; however, few practitioners are working in this arena. This mixed methods multiphase design study presents an example of a needs assessment process: assess before you assess. Participants included OT practitioners, residents in a low-income community housing complex, and older adult residents in another community housing complex. Methods included phenomenological and nonexperimental cross-sectional survey study design. Data analysis included coding, categorizing, and creating themes; composite scoring, Spearman correlations, and independent t tests for comparing variables. Results indicated that OT practitioners need more guidance and involvement to shift their paradigm from rehabilitation to community health promotion. Conducting needs assessments in three phases supports effective health promotion programming in community settings.
The use of ultrasonic guided waves for the inspection of square tube structures: Dispersion analysis and numerical and experimental studies
Authors: Wan Xiang , Liu Meiru , Zhang Xuhui , Fan Hongwei , Tse Peter W , Dong Ming , Wang Xing , Wei Huanhuan , Xu Cuihua , Ma Hongwei
Published: May 2020

Square steel tubes have been widely used in buildings and machines in civil engineering. The inspection of square tubes is becoming increasingly urgent and important to ensure the safety of these buildings and machines. However, the current most frequently used traditional ultrasonic inspection method is time-consuming and inefficient when dealing with long square tubes. There is an urgent need to develop an efficient approach to inspect square tubes. In this article, the use of ultrasonic guided waves is proposed. Phase and group velocity dispersion curves of square tube structures are first derived using the semi-analytical finite element method. An appropriate guided wave mode used for inspecting square tubes is selected. Ultrasonic guided waves propagating in normal, in-plane surface-damaged, and edge-damaged square tubes are numerically studied. It is illustrated that the monitoring points are able to receive reflected wave signals from both the in-plane surface and the edge damages. Experimental studies are also conducted to study ultrasonic guided waves interacting with circular through-hole damages located in surfaces and slot damages at edges. It is shown that both the circular through-hole damages located in different surfaces and slot damages at different edges can be clearly detected by reflected guided wave packets. It is found that the signal-to-noise ratios have been significantly improved after applying impedance matching to piezoelectric wafer transducers. The results have shown that ultrasonic guided waves are a promising and effective method for the inspection of square tubes.
Plasma eicosanoids as noninvasive biomarkers of liver fibrosis in patients with nonalcoholic steatohepatitis
Authors: Caussy Cyrielle , Chuang Jen-Chieh , Billin Andrew , Hu Tao , Wang Ya , Subramanian G. Mani , Djedjos C. Stephen , Myers Robert P. , Dennis Edward A. , Loomba Rohit
Published: May 2020

Background:

Eicosanoid and related docosanoid polyunsaturated fatty acids (PUFAs) and their oxygenated derivatives have been proposed as noninvasive lipidomic biomarkers of nonalcoholic steatohepatitis (NASH). Therefore, we investigated associations between plasma eicosanoids and liver fibrosis to evaluate their utility in diagnosing and monitoring NASH-related fibrosis.

Methods:

Our analysis used baseline eicosanoid data from 427 patients with biopsy-confirmed nonalcoholic fatty liver disease (NAFLD), and longitudinal measurements along with liver fibrosis staging from 63 patients with NASH and stage 2/3 fibrosis followed for 24 weeks in a phase II trial.

Results:

At baseline, four eicosanoids were significantly associated with liver fibrosis stage: 11,12-DIHETE, tetranor 12-HETE, adrenic acid, and 14, 15-DIHETE. Over 24 weeks of follow up, a combination of changes in seven eicosanoids [5-HETE, 7,17-DHDPA, adrenic acid, arachidonic acid (AA), eicosapentaenoic acid (EPA), 16-HDOHE, and 9-HODE) had good diagnostic accuracy for the prediction of ⩾1 stage improvement in fibrosis (AUROC: 0.74; 95% CI: 0.62–0.87), and a combination of four eicosanoids (7,17-DHDPA, 14,15-DIHETRE, 9-HOTRE, and free adrenic acid) accurately predicted improvement in hepatic collagen content (AUROC: 0.72; 95% CI: 0.50–0.77).

Conclusion:

This study provides preliminary evidence that plasma eicosanoids may serve as noninvasive biomarkers of liver fibrosis and may predict liver fibrosis improvement in NASH.
Acute mesenteric ischaemia in refractory shock on veno-arterial extracorporeal membrane oxygenation
Authors: Renaudier Marie , de Roux Quentin , Bougouin Wulfran , Boccara Johanna , Dubost Baptiste , Attias Arié , Fiore Antonio , de’Angelis Nicola , Folliguet Thierry , Mulé Sébastien , Amiot Aurélien , Langeron Olivier , Mongardon Nicolas
Published: May 2020

Background

Acute mesenteric ischaemia is a severe complication in critically ill patients, but has never been evaluated in patients on veno-arterial extracorporeal membrane oxygenation (V-A ECMO). This study was designed to determine the prevalence of mesenteric ischaemia in patients supported by V-A ECMO and to evaluate its risk factors, as well as to appreciate therapeutic modalities and outcome.

Methods

In a retrospective single centre study (January 2013 to January 2017), all consecutive adult patients who underwent V-A ECMO were included, with exclusion of those dying in the first 24 hours. Diagnosis of mesenteric ischaemia was performed using digestive endoscopy, computed tomography scan or first-line laparotomy.

Results

One hundred and fifty V-A ECMOs were implanted (65 for post-cardiotomy shock, 85 for acute cardiogenic shock, including 39 patients after refractory cardiac arrest). Overall, median age was 58 (48–69) years and mortality 56%. Acute mesenteric ischaemia was suspected in 38 patients, with a delay of four (2–7) days after ECMO implantation, and confirmed in 14 patients, that is, a prevalence of 9%. Exploratory laparotomy was performed in six out of 14 patients, the others being too unstable to undergo surgery. All patients with mesenteric ischaemia died. Independent risk factors for developing mesenteric ischaemia were renal replacement therapy (odds ratio (OR) 4.5, 95% confidence interval (CI) 1.3–15.7, p=0.02) and onset of a second shock within the first five days (OR 7.8, 95% CI 1.5–41.3, p=0.02). Conversely, early initiation of enteral nutrition was negatively associated with mesenteric ischaemia (OR 0.15, 95% CI 0.03–0.69, p=0.02).

Conclusions

Acute mesenteric ischaemia is a relatively frequent but dramatic complication among patients on V-A ECMO.
Selection signatures in tropical cattle are enriched for promoter and coding regions and reveal missense mutations in the damage response gene HELB
Authors: Naval-Sánchez Marina , Porto-Neto Laercio R. , Cardoso Diercles F. , Hayes Ben J. , Daetwyler Hans D. , Kijas James , Reverter Antonio
Published: May 2020

Background

Distinct domestication events, adaptation to different climatic zones, and divergent selection in productive traits have shaped the genomic differences between taurine and indicine cattle. In this study, we assessed the impact of artificial selection and environmental adaptation by comparing whole-genome sequences from European taurine and Asian indicine breeds and from African cattle. Next, we studied the impact of divergent selection by exploiting predicted and experimental functional annotation of the bovine genome.

Results

We identified selective sweeps in beef cattle taurine and indicine populations, including a 430-kb selective sweep on indicine cattle chromosome 5 that is located between 47,670,001 and 48,100,000 bp and spans five genes, i.e. HELB, IRAK3, ENSBTAG00000026993, GRIP1 and part of HMGA2. Regions under selection in indicine cattle display significant enrichment for promoters and coding genes. At the nucleotide level, sites that show a strong divergence in allele frequency between European taurine and Asian indicine are enriched for the same functional categories. We identified nine single nucleotide polymorphisms (SNPs) in coding regions that are fixed for different alleles between subspecies, eight of which were located within the DNA helicase B (HELB) gene. By mining information from the 1000 Bull Genomes Project, we found that HELB carries mutations that are specific to indicine cattle but also found in taurine cattle, which are known to have been subject to indicine introgression from breeds, such as N’Dama, Anatolian Red, Marchigiana, Chianina, and Piedmontese. Based on in-house genome sequences, we proved that mutations in HELB segregate independently of the copy number variation HMGA2-CNV, which is located in the same region.

Conclusions

Major genomic sequence differences between Bos taurus and Bos indicus are enriched for promoter and coding regions. We identified a 430-kb selective sweep in Asian indicine cattle located on chromosome 5, which carries SNPs that are fixed in indicine populations and located in the coding sequences of the HELB gene. HELB is involved in the response to DNA damage including exposure to ultra-violet light and is associated with reproductive traits and yearling weight in tropical cattle. Thus, HELB likely contributed to the adaptation of tropical cattle to their harsh environment.
Extracting chemical reactions from text using Snorkel
Authors: Mallory Emily K. , de Rochemonteix Matthieu , Ratner Alex , Acharya Ambika , Re Chris , Bright Roselie A. , Altman Russ B.
Published: May 2020

Background

Enzymatic and chemical reactions are key for understanding biological processes in cells. Curated databases of chemical reactions exist but these databases struggle to keep up with the exponential growth of the biomedical literature. Conventional text mining pipelines provide tools to automatically extract entities and relationships from the scientific literature, and partially replace expert curation, but such machine learning frameworks often require a large amount of labeled training data and thus lack scalability for both larger document corpora and new relationship types.

Results

We developed an application of Snorkel, a weakly supervised learning framework, for extracting chemical reaction relationships from biomedical literature abstracts. For this work, we defined a chemical reaction relationship as the transformation of chemical A to chemical B. We built and evaluated our system on small annotated sets of chemical reaction relationships from two corpora: curated bacteria-related abstracts from the MetaCyc database (MetaCyc_Corpus) and a more general set of abstracts annotated with MeSH (Medical Subject Headings) term Bacteria (Bacteria_Corpus; a superset of MetaCyc_Corpus). For the MetaCyc_Corpus, we obtained 84% precision and 41% recall (55% F1 score). Extending to the more general Bacteria_Corpus decreased precision to 62% with only a four-point drop in recall to 37% (46% F1 score). Overall, the Bacteria_Corpus contained two orders of magnitude more candidate chemical reaction relationships (nine million candidates vs 68,0000 candidates) and had a larger class imbalance (2.5% positives vs 5% positives) as compared to the MetaCyc_Corpus. In total, we extracted 6871 chemical reaction relationships from nine million candidates in the Bacteria_Corpus.

Conclusions

With this work, we built a database of chemical reaction relationships from almost 900,000 scientific abstracts without a large training set of labeled annotations. Further, we showed the generalizability of our initial application built on MetaCyc documents enriched with chemical reactions to a general set of articles related to bacteria.
Spaceflight induces novel regulatory responses in Arabidopsis seedling as revealed by combined proteomic and transcriptomic analyses
Authors: Kruse Colin P. S. , Meyers Alexander D. , Basu Proma , Hutchinson Sarahann , Luesse Darron R. , Wyatt Sarah E.
Published: May 2020

Background

Understanding of gravity sensing and response is critical to long-term human habitation in space and can provide new advantages for terrestrial agriculture. To this end, the altered gene expression profile induced by microgravity has been repeatedly queried by microarray and RNA-seq experiments to understand gravitropism. However, the quantification of altered protein abundance in space has been minimally investigated.

Results

Proteomic (iTRAQ-labelled LC-MS/MS) and transcriptomic (RNA-seq) analyses simultaneously quantified protein and transcript differential expression of three-day old, etiolated Arabidopsis thaliana seedlings grown aboard the International Space Station along with their ground control counterparts. Protein extracts were fractionated to isolate soluble and membrane proteins and analyzed to detect differentially phosphorylated peptides. In total, 968 RNAs, 107 soluble proteins, and 103 membrane proteins were identified as differentially expressed. In addition, the proteomic analyses identified 16 differential phosphorylation events. Proteomic data delivered novel insights and simultaneously provided new context to previously made observations of gene expression in microgravity. There is a sweeping shift in post-transcriptional mechanisms of gene regulation including RNA-decapping protein DCP5, the splicing factors GRP7 and GRP8, and AGO4,. These data also indicate AHA2 and FERONIA as well as CESA1 and SHOU4 as central to the cell wall adaptations seen in spaceflight. Patterns of tubulin-α 1, 3,4 and 6 phosphorylation further reveal an interaction of microtubule and redox homeostasis that mirrors osmotic response signaling elements. The absence of gravity also results in a seemingly wasteful dysregulation of plastid gene transcription.

Conclusions

The datasets gathered from Arabidopsis seedlings exposed to microgravity revealed marked impacts on post-transcriptional regulation, cell wall synthesis, redox/microtubule dynamics, and plastid gene transcription. The impact of post-transcriptional regulatory alterations represents an unstudied element of the plant microgravity response with the potential to significantly impact plant growth efficiency and beyond. What’s more, addressing the effects of microgravity on AHA2, CESA1, and alpha tubulins has the potential to enhance cytoskeletal organization and cell wall composition, thereby enhancing biomass production and growth in microgravity. Finally, understanding and manipulating the dysregulation of plastid gene transcription has further potential to address the goal of enhancing plant growth in the stressful conditions of microgravity.
Increased plasma lipoprotein-associated phospholipase A2 levels are associated with coronary slow flow
Authors: Ding Yao-dong , Pei Yu-qiang , Wang Rui , Yang Jia-xing , Zhao Yin-xin , Liu Xiao-li , Shen Hua , Ma Qian , Zhang Shuo , Ge Hai-long
Published: May 2020

Objective

Coronary slow flow (CSF) is characterized by delayed opacification of distal epicardial coronary arteries without significant coronary stenosis. In addition, The changes of lipoprotein-associated phospholipase A2 (Lp-PLA2) as a significant predictive factor for CSF remain controversial. The study aims to investigate the association between plasma Lp-PLA2 and CSF.

Methods

In this retrospective study, 170 consecutive patients who underwent coronary angiography were enrolled in Beijing Anzhen Hospital from January 2017 to September 2019, and were divided into CSF group and normal control groups. According to coronary blood flow rate measured by the thrombolysis in myocardial infarction frame count (TFC) method, CSF was defined as TFC > 27. Serum Lp-PLA2 levels were measured in an enzyme-linked immunosorbent assay.

Results

Lp-PLA2 levels were higher in the CSF group than in the control group (288.6 ± 50.3 versus 141.9 ± 49.7, P < 0.001) and were significantly correlated with the mean coronary artery thrombolysis in myocardial infarction (TIMI) frame count (r = 0.790, P<0.001). Logistic regression analysis showed that high Lp-PLA2 was independently associated with CSF after adjustment for conventional risk factors (OR = 1.040, CI = 1.022–1.059, P<0.001). Male sex (OR = 2.192, CI = 1.161–4.140, P = 0.016) and hypertension (OR = 1.965, CI = 1.034–3.736, P = 0.039) were also CSF risk factors. Receiver-operating characteristic curve (ROC) analysis showed that Lp-PLA2 levels can predict CSF severity; the predictive power was higher than the other risk factors.

Conclusion

Our study demonstrated that patients with CSF had higher circulating levels of Lp-PLA2 than normal controls. After adjustment for potential confounders, increased Lp-PLA2 was independently associated with presence of CSF.
Predicting the occurrence of venous thromboembolism: construction and verification of risk warning model
Authors: Shen Chen , Ge Binqian , Liu Xiaoqin , Chen Hao , Qin Yi , Shen Hongwu
Published: May 2020

Background

The onset of venous thromboembolism is insidious and the prognosis is poor. In this study, we aimed to construct a VTE risk warning model and testified its clinical application value.

Methods

Preliminary construction of the VTE risk warning model was carried out according to the independent risk warning indicators of VTE screened by Logistic regression analysis. The truncated value of screening VTE was obtained and the model was evaluated. ROC curve analysis was used to compare the test of Caprini risk assessment scale and VTE risk warning model. The cut-off value of the VTE risk warning model was used to evaluate the test effectiveness of the model for VTE patients with validation data set.

Results

The VTE risk warning model is p = ex / (1+ ex), x = − 4.840 + 2.557 • X10(1) + 1.432 • X14(1) + 2.977 • X15(1) + 3.445 • X18(1) + 1.086 • X25(1) + 0.249 • X34 + 0.282 • X41. ROC curve results show that: AUC (95%CI), cutoff value, sensitivity, specificity, accuracy, Youden index, Caprini risk assessment scale is 0.596 (0.552, 0.638), 5, 26.07, 96.50, 61.3%, 0.226, VTE risk warning model is 0.960 (0.940, 0.976), 0.438, 92.61, 91.83, 92.2%, 0.844, respectively, with statistically significant differences (Z = 14.521, P < 0.0001). The accuracy and Youden index of VTE screening using VTE risk warning model were 81.8 and 62.5%, respectively.

Conclusions

VTE risk warning model had high accuracy in predicting VTE occurrence in hospitalized patients. Its test performance was better than Caprini risk assessment scale. It also had high test performance in external population.
Surgical retrieval of PICC-related right atrial thrombus in a child with acute lymphoblastic leukemia: a case report
Authors: Luo Yu Lan , Zhang Jinmei , Tang Menglin
Published: May 2020

Background

Peripherally inserted central catheters (PICCs) are widely used in cancer patients for administering chemotherapy drugs, antibiotics, and nutrients. PICC-related thrombi are not uncommon and may result in pulmonary embolism and the formation of thrombi in the right atrium. The latter are associated with an increased risk of subsequent morbidity or mortality because of their potential for embolization in the pulmonary vasculature.

Case presentation

A 16-year-old male with acute lymphoblastic leukemia (ALL) was admitted to our hospital after an echocardiographic examination revealed a ring-like structure in the right atrium that was still present after 6 months’ anticoagulation treatment with aspirin. The boy had had a PICC inserted 2 years previously for chemotherapy; the PICC was intact and successfully removed 18 months after insertion when chemotherapy is finished. Subsequent computer tomography and radiography differentiated right atrial ring-shaped mass with a diameter of approximately 15 mm. Cardiac surgery was performed to remove the mass which was found to be a calcified thrombus.

Conclusion

Although this is a rare occurrence, recognition of the possibility of a calcified thrombus may minimize the misdiagnosis of PICC-related thrombus and allow surgical retrieval if the thrombus is sufficiently large.
Frequency of anaplastic lymphoma kinase rearrangements in Moroccan patients with non small cell lung cancer: a multi-institutional national retrospective study
Authors: El yacoubi Hind , Sow Mohamed Lemine , Kettani Fouad , Gamra Lamia , Mestari Amina , Jabri Lamia , Elghissassi Ibrahim , Errihani Hassan
Published: May 2020

Background

Anaplastic lymphoma kinase (ALK) rearrangement is a predictive factor of response to ALK inhibitors in non small cell lung cancer (NSCLC). The prevalence of ALK rearrangements is well known in Whites and Asians. However, data identifying the frequency of this rearrangement in Moroccan and North African population are lacking. The objective of this study is to report the frequency of ALK rearrangement in a group of Moroccan patients with NSCLC.

Methods

A retrospective study was performed enrolling 120 Moroccan patients with NSCLC whose biopsy samples were tested for ALK rearrangement in order to identify the frequency of ALK rearrangement and its potential association with selected variables. The ALK testing was established using fluorescent in situ hybridization (FISH) or immunohistochemistry (IHC).

Results

The frequency of ALK rearrangement was 4.2% (5/120). All positive cases were males with advanced adenocarcinoma. ALK rearrangements prevalence was significantly higher in older patients.

Conclusions

The frequency of ALK rearrangements among the Moroccan population tends to correlate with the average frequency reported worldwide, with some specific features. Further prospective studies with larger patients’ numbers are needed to verify these findings.
Utilization of personal protective equipment and associated factors among building construction workers in Addis Ababa, Ethiopia, 2019
Authors: Alemu Addisu Alehegn , Yitayew Meseret , Azazeh Aklilu , Kebede Sofia
Published: May 2020

Background

Personal protective equipment (PPE) is a material, device, equipment, or clothing used or worn by workers to reduce their chance of exposure or contact with any harmful material or energy that causes injury, disease, or even death. The use of PPE is a universal legal requirement to reduce occupational injuries and illnesses in the workplace. Therefore, this study was conducted to assess PPE utilization and its associated factors among building construction workers in Addis Ababa, Ethiopia, 2019.

Methods

Institution based quantitative cross-sectional study was conducted on the selected construction sites of Addis Ababa city from April 1 to May 18, 2019. Data were collected among all (206) building construction workers via interviewer-administered questionnaires. Data were entered into Epi info version 7.1 and exported to SPSS version 25 statistical software for analysis. Variables with a p-value of less than 0.20 in bivariate analysis were included in multivariate logistic regression. Finally, variables with a p-value of less than 0.05 in multivariate analysis were considered as significantly associated.

Results

The utilization of at least one PPE among building construction workers in Addis Ababa was found to be 38%. The majority (41.1%) of the participants’ reason for not using PPE were the unavailability of PPE followed by absence of orientation on using PPE (21.3%). The majority (35.3%) and (32.2%) of participants knew abrasion as a type of injury and suffered from abrasion respectively. Factors associated with utilization of PPE were the presence of training on PPE use (AOR = 4.8; 95% CI: 2.3, 10.3), presence of safety training (AOR = 2,8; 95% CI:1.5, 5.2), safety orientation before commencing work (AOR = 4.0; 95% CI:1.9, 9.0) and presence of supervision (AOR = 5.0; 95% CI:1.9,13).

Conclusions

PPE utilization among building construction workers in Addis Ababa was low. The main reasons for non-utilization of PPE were unavailability of the materials and the absence of orientation on using PPE. The presence of PPE use training, presence of safety training, safety orientation, and governmental supervision were factors associated with PPE utilization. There should be continuous supervision of construction sites to assure all workers get material and training on how to use it.
Magnitude of home delivery and associated factors among child bearing age mothers in Sherkole District, Benishangul Gumuz regional state-Western-Ethiopia
Authors: Berhe Resom , Nigusie Adane
Published: May 2020

Background

The World Health Organization estimates that globally only 43% of women have access to skilled care during deliveries and the rest are exposed to unskilled delivery service. A recent Ethiopian Demographic and Health Survey report stated that maternal death was 412 per 100,000 in 2016.This still indicates that maternal health remains a major public health problem in Ethiopia irrespective of the government’s measure to institutional delivery. Therefore, the aim of this study was to assess the magnitude of home delivery and associated factors among women of child bearing age in Sherkole district, Western Ethiopia.

Methods

A community based cross sectional study was conducted among women aged 15–49 years in Sherkole district, Benishangul Gumuz region from January to June 2018. A total of 451 randomly selected women were included in the study. Stratified sampling followed by simple random sampling technique was used to select the study participants. Data were collected using pretested and structured questionnaires. Bivariate and multivariate logistic regression models were fitted to identify factors associated with home delivery among women in the child bearing age. An adjusted odds ratio with a 95% confidence interval was computed to determine the level of significance.

Results

The magnitude of home delivery was 353 (80%) and were assisted by non-skilled birth attendants. Mothers whose husband chooses the place of delivery [AOR: 5.6, 95% CI (2.1–15.2), Mothers’ occupation ([AOR: 0.21 95% C I (0.08–0.57), ANC visit [AOR: 95 CI: 5.1(1.6–15.8), decision making [AOR: 95 CI: 0.3(0.01–0.7)] and traditional remedies [AOR: 95%CI: 0.03 (0.01–0.09)] were significantly associated with home delivery.

Conclusions

Based on the findings of the survey, it was concluded that the overall magnitude of home delivery was found to be high. Therefore, it is recommended that the promotion of antenatal care follow-up with maternal and child health information particularly on delivery complications or danger signs needs due attention and remedial actions. In addition, it is indispensable introducing defaulter tracing mechanisms in ANC services, by learning from experiences of settings that have already adopted it.
Unsafe child feces disposal status in Ethiopia: what factors matter? Analysis of pooled data from four demographic and health surveys
Authors: Sahiledengle Biniyam
Published: May 2020

Background

The only safest way to dispose of a child’s feces is to help the child use a toilet or, for very young children, to put or rinse their feces into a toilet, whereas other methods are considered unsafe. This study aimed to determine the magnitude and factors associated with unsafe child feces disposal in Ethiopia.

Methods

This was a cross-sectional study using pooled data from the four rounds of Demographic and Health Surveys (DHS) conducted in Ethiopia (2000, 2005, 2011, and 2016). Data on child feces disposal practice was collected for all children born during the 5 years preceding survey. Mothers were asked for the youngest child born, “The last time child passed stools, what was done to dispose of the stools?”.Descriptive statistics were computed to illustrate the given data. Multivariable logistic regression was performed to identify factors associated with unsafe child feces disposal.

Results

The pooled dataset contains data for 40,520 children younger than 5 years, male accounts 20,629 (50.9%). Overall, 77.7% (95%CI: 76.3–79.0) of children feces disposed of unsafely. In the multivariable logistic regression model, those mothers whose child was 13–24 months [AOR: 0.68, 95% CI: (0.60–0.78)] and ≥ 25 months [AOR: 0.66, 95% CI: (0.60–0.72)] were lower odds of unsafe child’s feces disposal. Children born into households having two or fewer children were 33% lower [AOR: 0.67, 95% CI: (0.56–0.79)] odds of unsafe child’s feces disposal than their counterparts. The odds of disposing of feces unsafely among households having improved toilet facility was 76% lower [AOR: 0.24, 95% CI: (0.19–0.29)] that of households lacking such facilities. Further, being an urban resident, having improved drinking water facility, a high level of maternal and paternal education, paternal occupational status (work in non-agriculture), and maternal age (25–34 and ≥ 35 years) were factors that associated with lower odds of unsafe child’s feces disposal.

Conclusions

Three in four Ethiopian children feces disposed of unsafely. Household and socio-demographic factors, such as access to improved toilet facility, the child’s age (older age), and both higher maternal and paternal education levels were important factors that significantly associated with lower odds of unsafe child feces disposal.
Hepatic steatosis is associated with abnormal hepatic enzymes, visceral adiposity, altered myocardial glucose uptake measured by 18F-FDG PET/CT
Authors: Hu Lijun , Shao Xiaoliang , Qiu Chun , Shao Xiaonan , Wang Xiaosong , Niu Rong , Wang Yuetao
Published: May 2020

Background

Nonalcoholic fatty liver disease (NAFLD) is a multisystem disease that affects the liver and a variety of extra-hepatic organ systems. This study aimed to investigate the relationship between hepatic steatosis and glucose metabolism in liver and extra-hepatic tissues and organs.

Methods

The whole body 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT) images of 191 asymptomatic tumor screening patients were retrospectively analyzed. Patients with the ratio of spleen/liver CT densities > 1.1 were defined to have NAFLD, and their clinical symptoms, laboratory markers, FDG uptake in a variety of tissues and organs including heart, mediastinal blood pool, liver, spleen, pancreas, and skeletal muscle, as well as abdominal adipose tissue volumes including visceral adipose tissue (VAT) volume and subcutaneous adipose tissue (SAT) volume were compared with those of the non-NAFLD patients and used to analyze the independent correlation factors of NAFLD.

Results

Among the 191 patients, 33 (17.3%) were NAFLD, and 158 (82.7%) were non-NAFLD. There was no significant correlation between the mean standardized uptake value (SUVmean) and CT density of liver as well as the ratio of spleen/liver CT densities. Hepatic steatosis, but not FDG intake, was more significant in NAFLD patients with abnormal liver function than those with normal liver function. Compared with the non-NAFLD patients, NAFLD patients had significantly reduced myocardial glucose metabolism, but significantly increased mediastinal blood pool, spleen SUVmean and abdominal adipose tissue volumes (including VAT and SAT volumes) (P < 0.05). Multivariate regression analysis showed that elevated serum ALT, increased abdominal VAT volume, and decreased myocardial FDG uptake were independent correlation factors for NAFLD. Further studies showed that hepatic steatosis and myocardial FDG uptake were mildly linearly correlated (r = 0.366 with hepatic CT density and − 0.236 with the ratio of spleen/liver CT densities, P < 0.05).

Conclusions

NAFLD is a systemic disease that can lead to the change of glucose metabolism in some extra-hepatic tissues and organs, especially the myocardium.
Assessment of dental arch stability after orthodontic treatment and oral rehabilitation in complete unilateral cleft lip and palate and non-clefts patients using 3D stereophotogrammetry
Authors: Rezende Pucciarelli Maria Giulia , de Lima Toyoshima Guilherme Hideki , Marchini Oliveira Thais , Marques Honório Heitor , Sforza Chiarella , Soares Simone
Published: May 2020

Background

Although arch stability has been studied in patients without a cleft, evidence for patients with a cleft is sparse. Therefore, we compared the dimensions and stability of dental arches in cleft lip and palate patients and those without a cleft.

Methods

Forty participants, 20 with a complete unilateral cleft lip and palate and 20 non-cleft patients aged from 18 to 30 years, with anterior and/or posterior crossbite and receiving orthodontic treatment were evaluated retrospectively. Eighty gypsum casts were digitized using a laser model scanner casts for both groups made immediately after the orthodontic treatment was completed (T1). Also, for the Cleft Lip and Palate group, casts were obtained and digitized 1 year after implant-supported rehabilitation (T2) and for the Non-Cleft Lip and Palate group, 1 year after the conclusion of the orthodontic treatment (T2). The formula: Δ = T2-T1 evaluated the stability of dental arches for inter-canine distances (C-C′), inter-molar distances (M-M’), arch length (I-M), palate surface and volume. The dimensions of the dental arches were measured digitally. The independent t test was used for statistical analysis (α = 0.05).

Results

A statistical difference was found in the stability of the groups for inter-canine (cleft area) measurement. At the times T1 and T2, a statistically significant difference was found in the arch length, surface and volume.

Conclusions

This study concluded that in the Cleft Lip and Palate group, the maxillary dimensions were not stabilized after 1 year of orthodontic and prosthodontic treatment (mainly for the inter-canine linear measurement) and that the transverse arch dimensions were smaller compared with those of non-cleft patients.
The efficacy of a mobile phone application to improve adherence to treatment and self-management in people with chronic respiratory disease in Romanian population – a pilot study
Authors: Munteanu Laura Adela , Frandes Mirela , Timar Bogdan , Tudorache Emanuela , Fildan Ariadna Petronela , Oancea Cristian , Tofolean Doina Ecaterina
Published: May 2020

Background

Many studies assessed the effect of mobile phone applications on self-management outcomes in patients with asthma, but all of them presented variable results. In this paper. we examined the effect of a mobile phone application on self-management and disease control in Romanian population.

Methods

This study included 93 patients diagnosed with asthma that were recalled every three months for a year for assessment and treatment. Patients were divided into two groups. The first group included patients that received treatment, and the second group received treatment and also used the smartphone application. Number of exacerbations and asthma control test (ACT) were recorded.

Results

The ACT score was significantly higher for asthma patients using also the mobile application than for the patients using the treatment alone, for all the evaluation moments (Mann-Whitney U test, p <  0.001). Also, we found significant differences between the ACT score with-in each group, observing a significant improvement of the score between evaluations and baseline (related-samples Friedman’s test with Bonferroni correction, p <  0.001). When considering the exacerbations rate, significantly less patients using the application presented exacerbations, 10.30% vs. 46.30% (Pearson Chi-square test, X2 (1) = 13.707, p <  0.001).

Conclusion

Our study indicates that smartphone applications are an effective way to improve asthma control and self-management when used continually in our population. We found significant positive effects in disease control and exacerbation frequency.
Geographic availability and accessibility of day care services for people with dementia in Ireland
Authors: Pierse Tom , Keogh Fiona , O’Shea Eamon , Cullinan John
Published: May 2020

Background

Day care is an important service for many people with dementia and their carers. In Ireland, day care services for people with dementia are delivered by a mix of dementia-specific day care centres as well as generic day care centres that cater for people with dementia to various degrees. In this paper we examine the geographic distribution of day care services for people with dementia relative to potential need.

Methods

Using a national survey of day care centres, we estimate the current availability of day care services for people with dementia in the country. We use geographic information systems (GIS) to map day care provision at regional and sub-regional levels and compare this to the estimated number of people with dementia in local areas.

Results

There is significant variation across the country in the existing capacity of day care centres to cater for people with dementia. The number of places per 100 persons with dementia in the community varies from 14.2 to 21.3 across Community Health Organisation areas. We also show that 18% of people with dementia do not live within 15kms of their nearest day care centre.

Conclusion

Currently, day care centres, in many parts of the country, have limited capacity to provide a service for people with dementia who live in their catchment area. As the number of people with dementia increases, investment in day care centres should be targeted to areas where need is greatest. Our GIS approach provides valuable evidence that can help inform decisions on future resource allocation and service provision in relation to day care.
Theoretical and methodological considerations in evaluating large-scale health information technology change programmes
Authors: Cresswell Kathrin , Sheikh Aziz , Franklin Bryony Dean , Krasuska Marta , Nguyen Hung The , Hinder Susan , Lane Wendy , Mozaffar Hajar , Mason Kathy , Eason Sally , Potts Henry W. W. , Williams Robin
Published: May 2020

Background

Attempts to achieve digital transformation across the health service have stimulated increasingly large-scale and more complex change programmes. These encompass a growing range of functions in multiple locations across the system and may take place over extended timeframes. This calls for new approaches to evaluate these programmes.

Main body

Drawing on over a decade of conducting formative and summative evaluations of health information technologies, we here build on previous work detailing evaluation challenges and ways to tackle these. Important considerations include changing organisational, economic, political, vendor and markets necessitating tracing of evolving networks, relationships, and processes; exploring mechanisms of spread; and studying selected settings in depth to understand local tensions and priorities.

Conclusions

Decision-makers need to recognise that formative evaluations, if built on solid theoretical and methodological foundations, can help to mitigate risks and help to ensure that programmes have maximum chances of success.
Multi-faceted analysis provides little evidence for recurrent whole-genome duplications during hexapod evolution
Authors: Roelofs Dick , Zwaenepoel Arthur , Sistermans Tom , Nap Joey , Kampfraath Andries A. , Van de Peer Yves , Ellers Jacintha , Kraaijeveld Ken
Published: May 2020

Background

Gene duplication events play an important role in the evolution and adaptation of organisms. Duplicated genes can arise through different mechanisms, including whole-genome duplications (WGDs). Recently, WGD was suggested to be an important driver of evolution, also in hexapod animals.

Results

Here, we analyzed 20 high-quality hexapod genomes using whole-paranome distributions of estimated synonymous distances (KS), patterns of within-genome co-linearity, and phylogenomic gene tree-species tree reconciliation methods. We observe an abundance of gene duplicates in the majority of these hexapod genomes, yet we find little evidence for WGD. The majority of gene duplicates seem to have originated through small-scale gene duplication processes. We did detect segmental duplications in six genomes, but these lacked the within-genome co-linearity signature typically associated with WGD, and the age of these duplications did not coincide with particular peaks in KS distributions. Furthermore, statistical gene tree-species tree reconciliation failed to support all but one of the previously hypothesized WGDs.

Conclusions

Our analyses therefore provide very limited evidence for WGD having played a significant role in the evolution of hexapods and suggest that alternative mechanisms drive gene duplication events in this group of animals. For instance, we propose that, along with small-scale gene duplication events, episodes of increased transposable element activity could have been an important source for gene duplicates in hexapods.
Evaluation of the potential incidence of COVID-19 and effectiveness of containment measures in Spain: a data-driven approach
Authors: Aleta Alberto , Moreno Yamir
Published: May 2020

Background

We are currently experiencing an unprecedented challenge, managing and containing an outbreak of a new coronavirus disease known as COVID-19. While China—where the outbreak started—seems to have been able to contain the growth of the epidemic, different outbreaks are nowadays present in multiple countries. Nonetheless, authorities have taken action and implemented containment measures, even if not everything is known.

Methods

To facilitate this task, we have studied the effect of different containment strategies that can be put into effect. Our work referred initially to the situation in Spain as of February 28, 2020, where a few dozens of cases had been detected, but has been updated to match the current situation as of 13 April. We implemented an SEIR metapopulation model that allows tracing explicitly the spatial spread of the disease through data-driven stochastic simulations.

Results

Our results are in line with the most recent recommendations from the World Health Organization, namely, that the best strategy is the early detection and isolation of individuals with symptoms, followed by interventions and public recommendations aimed at reducing the transmissibility of the disease, which, although might not be sufficient for disease eradication, would produce as a second order effect a delay of several days in the raise of the number of infected cases.

Conclusions

Many quantitative aspects of the natural history of the disease are still unknown, such as the amount of possible asymptomatic spreading or the role of age in both the susceptibility and mortality of the disease. However, preparedness plans and mitigation interventions should be ready for quick and efficacious deployment globally. The scenarios evaluated here through data-driven simulations indicate that measures aimed at reducing individuals’ flow are much less effective than others intended for early case identification and isolation. Therefore, resources should be directed towards detecting as many and as fast as possible the new cases and isolate them.