bluuebunny/crossref_metadata_2025 huggingface dataset:
Applying the theory of planned behavior for prediction of oocyte donation intention among Iranian women
Authors: Balochi Hanie , Hadizadeh-Talasaz Fatemeh , Bahri Narjes , Mohammadzadeh Fatemeh
Published: July 2023

Background

Oocyte donation is a complex and multifaceted behavior in women. Due to the acute deficiency of donated oocytes, it is necessary to identify the factors affecting the desire to donate. Planned behavior theory is a suitable model for explaining and predicting behavior in many behavioral domains. The aim of this study was to predict oocyte donation intention using the theory of planned behavior.

Methods

This cross-sectional study was performed on 556 women who were covered by the comprehensive health service centers in Gonabad and Neyshabour cities in 2020. Sampling was performed by the two-step method in Gonabad city and by the convenience sampling method in Neyshabour city. Data were collected online using researcher-made questionnaires included oocyte donation awareness questionnaire and oocyte donation intention questionnaire (based on the TPB constructs). The validity of the questionnaires was confirmed by face and content validity and its reliability was confirmed by Cronbach's alpha coefficient. Data were analyzed in SPSS software (version 16) using hierarchical linear regression. The statistical significance was considered as P < 0.05.

Results

The results showed that there was a significant positive correlation between the oocyte donation intention with all constructs of planned behavioral theory (P < 0.050). Planned behavior theory constructs explained 47% of the variance of oocyte donation intention. In addition, constructs of perceived power (β = 0.461), control beliefs (β = 0.154) and normative beliefs (β = 0.125) were the strongest predictors of oocyte donation intention, respectively.

Conclusion

Planning and implementing educational courses according to the constructs of the theory of planned behavior can be a great step toward the elimination of oocyte deficiency and infertility problems. Also performing of intervention or training strategies in the field of oocyte donation requires the enhancement of social norms and perceived behavioral control in the population under study.
Ultrasound-stimulated microbubbles enhancement of fractionated radiation for tumor treatment
Authors: Sharma Deepa , McNabb Evan , Law Niki , Cumal Aaron , Czarnota Gregory J
Published: July 2023

Background

Radiation therapy (XRT) causes numerous biological changes in tumor microenvironment. Radiation vascular response, due to endothelial disruption, can influence treatment outcomes in a dose-dependent manner. Ultrasound-stimulated microbubbles (USMB) have also been demonstrated to create a vascular response in the tumor microenvironment and enhance tumor response when used in combination with XRT. Single doses of 8–10 Gy are known to induce activation of acid sphingomyelinase (ASMase)-induced ceramide production, causing vascular damage. Destruction of vasculature results in endothelial apoptosis followed by tumor cell death. The effect of tumor response is known to be synergistic by 10-fold higher cell kill observed when USMB is combined with radiation.

Methods

In this study, we used an USMB approach in combination with conventional low dose fractionated radiation to enhance endothelial cell responses to XRT in human PC3 prostate cancer xenograft model. Mice were divided into untreated, USMB therapy, fractionated XRT, and combined USMB therapy followed by XRT (USMB + XRT) groups. USMB therapy was delivered twice per week in the USMB-alone and combined USMB + XRT treatment groups over four weeks. Radiation treatments were delivered in fractions of 2 Gy/day (total 40 Gy in 20 fractions, BED10 = 48 Gy) in the XRT-alone and combined USMB + XRT groups. The treatment outcome was evaluated using histopathology, power Doppler, and immunohistochemistry assays.

Results

Tumor growth assessment showed that sizes of tumors increased in the control and the single treatment groups over a treatment period of four weeks, but significantly decreased with the combined treatments of USMB + XRT. Immunohistochemical analysis indicated a statistically significant vascular disruption in mice that received treatment involving a full 4-week schedule of combined (USMB + XRT) treatments. A statistically significant increase in vascular disruption was demonstrated through CD68 and trichrome fibrosis staining. Changes in local perfusion assessed using high-frequency power Doppler imaging demonstrated attenuated blood flow in the combined group.

Discussion and conclusions

This work demonstrates the efficacy of using USMB as a radiation sensitizer in a mouse model of human PC3 tumor xenograft. This radiation treatment enhancement modality has the advantage of targeting tumor vasculature with ultrasound stimulation that can be implemented prior to radiation treatment.
A novel PEGylated form of granulocyte colony-stimulating factor, mecapegfilgrastim, for peripheral blood stem cell mobilization in patients with hematologic malignancies
Authors: Wen Jingjing , Zhou Qiaolin , Shi Lin , Xu Fang , Liu Yiping , Su Jing , Zhang Ya , Qu Wen , Yue Jing
Published: July 2023

Background

The Pegylated recombinant human granulocyte colony stimulating factor (PEG-rhG-CSF) has longer half-life and is given once only, which is more comfortable for patients. We aimed to evaluate the efficacy of mecapegfilgrastim for hematopoietic stem cell (HSC) mobilization in patients with hematologic malignancies and to explore the potential factors related to HSC mobilization.

Methods

A retrospective analysis was performed on patients who underwent HSC mobilization in the hematology department of Mianyang Central Hospital from April 2016 to November 2022. The number of CD34 + cells collected was compared between the patients receiving mecapegfilgrastim (PEG group) and those receiving recombinant human granulocyte colony-stimulating factor (rhG-CSF group), and the possible factors for mobilization failure were analyzed.

Results

The success rates of collecting CD34 + cells in the PEG group and rhG-CSF group were 80.6% and 67.7%, respectively (χ = 1.444, P = 0.229). The median CD34 + cell counts were 3.62 × 10^6/kg and 2.92 × 10^6/kg (P = 0.178), respectively. After combination with plerixafor for mobilization, the median number of CD34 + cells collected in the PEG group and rhG-CSF group were 3.64 × 10^6/kg and 3.92 × 10^6/kg, respectively, with no significant difference (P = 0.754). There was no significant difference in hematopoietic cell recovery or infection between the groups (P > 0.05). Multivariate analysis showed that more than 5 cycles of chemotherapy (OR = 15.897, 95% CI: 1.766-143.127, P = 0.014), a precollection WBC count < 32 × 10^9/L (OR = 14.441, 95% CI: 2.180-95.657, P = 0.006) and a precollection to premobilization lymphocyte ratio < 1.7 (OR = 11.388, 95% CI: 2.129–60.915, P = 0.004) were independent risk factors for HSC mobilization failure.

Conclusions

The HSC mobilization efficacy of mecapegfilgrastim in patients with hematologic malignancies was comparable to that of rhG-CSF, and combination with plerixafor for mobilization was feasible and effective. Patients with more than 5 cycles of chemotherapy before HSC mobilization, a precollection WBC count lower than 32 × 10^9/L, and a precollection lymphocyte count less than 1.7 times the premobilization lymphocyte count have a high probability of HSC mobilization failure.
Depression and its association with psychological factors among adolescents living with HIV in Southwestern Nigeria
Authors: RO Lawal , Akinsulore Adesanmi , OA Oginni , OO Aloba , SK Mosaku , AS Akanmu
Published: July 2023

Objective

The aim was to determine the prevalence of depressive disorder and associated psychological factors among adolescents living with HIV/AIDS.

Methods

One hundred and five adolescents with HIV were assessed for self-esteem, internalized HIV stigma and diagnosed of depressive disorder. Chi square and t tests were used to test associations and hierarchical logistic regression used to identify independent risk factors for depression.

Results

The mean age of participants was 16.5 (± 1.97) years and 55.2% were males. Mean stigma scores were significantly higher in those with depressive disorder (16.53 ± 3.85) when compared with those without (13.42 ± 3.464) and this difference was statistically significant (t = 3.17, p = 0.01). The mean self-esteem scores were significantly lower in participants with depressive disorder (17.53 ± 4.69) compared to those without depressive disorder (19.71 ± 3.86), though not significant (t = 1.96, p = 0.053). Depressive disorder was further significantly associated with female sex, being in romantic relationship, decline in work output due to HIV and HIV stigma. Independent risk factors were sex and HIV stigma.

Conclusion

Depressive disorder is common among adolescents living with HIV infection in Nigeria. The association between HIV stigma and depression, thus suggests the need for prevention strategies targeting the impacts of HIV infection among adolescents.
Impulsive choice in individuals with comorbid amphetamine use disorder and attention deficit-hyperactivity disorder
Authors: Brynte Christoffer , Khemiri Lotfi , Stenström Hannes , Konstenius Maija , Lindström Nitya-Jayaram , Franck Johan
Published: July 2023

Background

Amphetamine use disorder (AMPH) and attention deficit-hyperactivity disorder (ADHD) often co-occur and are associated with poor treatment outcomes. Elevated impulsivity is a core feature in both disorders. Little is known however about the specific neurocognitive profile regarding different facets of impulsivity, and specifically impulsive choice, in comorbid populations.

Methods

Three groups (ADHD + AMPH, ADHD only and healthy controls (HC)) were assessed with self-reported impulsivity and cognitive tasks of impulsive choice, operationalized as delay aversion (DA) and reflection impulsivity.

Results

Twenty-nine participants with comorbid ADHD + AMPH, 25 participants with ADHD only and 116 HC completed screening, including self-rating scales, and cognitive testing. 20, 16 and 114 participants completed computerized cognitive tasks in the ADHD + AMPH group, ADHD group and HC group, respectively. The ADHD + AMPH group reported significantly higher motor, attentional and non-planning impulsiveness, and showed a significantly higher degree of impulsive choice, compared to both groups. There were no differences in task-related impulsiveness between ADHD only and HC.

Conclusions

The current findings suggest that individuals with ADHD + AMPH have overall elevated levels of impulsivity compared to individuals with ADHD only. In addition, that ADHD + AMPH is specifically associated with impairments in task-related impulsive choice, which was not found in ADHD only compared to HC. The neurocognitive profile in this specific patient group may represent a need for more systematic screening within healthcare settings in order to develop effective and targeted treatment for comorbid patients.

Trial registration

EudraCT, 2012–004298-20.
Effects of a multi-component alcohol prevention program in the workplace on hazardous alcohol use among employees
Authors: Elling Devy L. , Almquist Ylva B. , Wennberg Peter , Sundqvist Kristina
Published: July 2023

Background

The workplace can be affected negatively by hazardous alcohol use, and intervening at an early stage remains a challenge. Recently, a multi-component alcohol prevention program, Alcohol Policy and Managers’ skills Training (hereafter, ‘APMaT’), was delivered at the organizational level. In a previous outcome evaluation, APMaT appeared to be effective at the managerial level. The current study takes a step further by aiming to evaluate the effectiveness of APMaT in decreasing the alcohol risk level among employees.

Methods

Data from 853 employees (control: n = 586; intervention: n = 267) were gathered through a cluster-randomized study. To analyze changes in the odds of hazardous alcohol use among employees, multilevel logistic regression was applied using group (control vs. intervention), time (baseline vs. 12-month follow-up), and the multiplicative interaction term (group × time) as the main predictors. The intervention effect was further adjusted for sociodemographic characteristics and policy awareness.

Results

No statistically significant difference was observed in the odds of hazardous alcohol use, although employees in the intervention group showed a larger decrease compared to the control group. This remained even after adjusting for several factors, including the sociodemographic factors and policy awareness.

Conclusions

The findings are insufficient to determine the effectiveness of APMaT at the employee level at the current stage of the evaluation. Future studies should strive to identify issues with implementation processes in workplace-based alcohol interventions.

Trial registration

The trial was retrospectively registered on 11/10/2019; ISCRTN ID: ISRCTN17250048.
The perceptions and experience of developing patient (version of) guidelines: a descriptive qualitative study with Chinese guideline developers
Authors: Yan Lijiao , Hu Jiale , Yu Zeyu , Li Shelly-Anne , Graham Karen , Scott Sarah E. , Shen Chen , Jin Xuejing , Liu Jianping
Published: July 2023

Objective

To understand developers’ perception of patient (versions of) guidelines (PVGs), and identify challenges during the PVG development, with the aim to inform methodological guidance for future PVG development.

Methods

We used a descriptive qualitative design. Semi-structured interviews were conducted virtually from December 2021 to April 2022, with a purposive sampling of 12 PVG developers from nine teams in China. Conventional and directed content analysis was used for data analysis.

Results

The interviews identified PVG developers’ understanding of PVGs, their current practice experience, and the challenges of developing PVGs. Participants believed PVGs were a type of health education material for patients; therefore, it should be based on patient needs and be understandable and accessible. Participants suggested that PVGs could be translated/adapted from one or several clinical practice guidelines (CPG), or developed de novo (i.e., the creation of an entirely new PVG with its own set of research questions that are independent of existing CPGs). Participants perceived those existing methodological guidelines for PVG development might not provide clear instructions for PVGs developed from multiple CPGs and from de novo development. Challenges to PVG development include (1) a lack of standardized and native guidance on developing PVGs; (2) a lack of standardized guidance on patient engagement; (3) other challenges: no publicly known and trusted platform that could disseminate PVGs; concerns about the conflicting interests with health professionals.

Conclusions and practice implications

Our study suggests clarifying the concept of PVG is the primary task to develop PVGs and carry out related research. There is a need to make PVG developers realize the roles of PVGs, especially in helping decision-making, to maximize the effect of PVG. It is necessary to develop native consensus-based guidance considering developers’ perspectives regarding PVGs.
The current status of surgical care in the Asia–Pacific region and opportunities for improvement: proceedings
Authors: Qin Rennie X. , Fowler Zachary G. , Jayaram Anusha , Stankey Makela , Yoon Sangchul , McLeod Elizabeth , Park Kee B.
Published: July 2023

The World Health Assembly resolution 68.15 recognised emergency and essential surgery as a critical component of universal health coverage. The first session of the three-part virtual meeting series on Strategic Planning to Improve Surgical, Obstetric, Anaesthesia, and Trauma Care in the Asia–Pacific Region focused on the current status of surgical care and opportunities for improvement. During this session, Ministries of Health and World Health Organization (WHO) Regional Directors shared country- and regional-level progress in surgical system strengthening. The WHO Western Pacific Regional Office (WPRO) has developed an Action Framework for Safe and Affordable Surgery, whilst the WHO South-East Asia Regional Office (SEARO) highlighted their efforts in emergency obstetric care, workforce strengthening, and blood safety. Numerous countries have begun developing and implementing National Surgical, Obstetric, and Anaesthesia Plans (NSOAPs). Participants agreed surgical system strengthening is an integral component of universal health coverage, pandemic preparedness, and overall health system resilience. Participants discussed common challenges, such as the COVID-19 pandemic, climate change, workforce capacity building, and improving access for hard-to-reach populations. They generated and shared common solutions, including strengthening surgical care capacity in first-level hospitals, anaesthesia task-shifting, remote training, and integrating surgical care with public health, preventive care, and emergency preparedness. Moving forward, participants committed to developing and implementing NSOAPs and agreed on the need to raise political awareness, build a broad-based movement, and form intersectoral collaborations.
Molecular and metabolic regulation of immunosuppression in metastatic pancreatic ductal adenocarcinoma
Authors: Gautam Shailendra K. , Batra Surinder K. , Jain Maneesh
Published: July 2023

Immunosuppression is a hallmark of pancreatic ductal adenocarcinoma (PDAC), contributing to early metastasis and poor patient survival. Compared to the localized tumors, current standard-of-care therapies have failed to improve the survival of patients with metastatic PDAC, that necessecitates exploration of novel therapeutic approaches. While immunotherapies such as immune checkpoint blockade (ICB) and therapeutic vaccines have emerged as promising treatment modalities in certain cancers, limited responses have been achieved in PDAC. Therefore, specific mechanisms regulating the poor response to immunotherapy must be explored. The immunosuppressive microenvironment driven by oncogenic mutations, tumor secretome, non-coding RNAs, and tumor microbiome persists throughout PDAC progression, allowing neoplastic cells to grow locally and metastasize distantly. The metastatic cells escaping the host immune surveillance are unique in molecular, immunological, and metabolic characteristics. Following chemokine and exosomal guidance, these cells metastasize to the organ-specific pre-metastatic niches (PMNs) constituted by local resident cells, stromal fibroblasts, and suppressive immune cells, such as the metastasis-associated macrophages, neutrophils, and myeloid-derived suppressor cells. The metastatic immune microenvironment differs from primary tumors in stromal and immune cell composition, functionality, and metabolism. Thus far, multiple molecular and metabolic pathways, distinct from primary tumors, have been identified that dampen immune effector functions, confounding the immunotherapy response in metastatic PDAC. This review describes major immunoregulatory pathways that contribute to the metastatic progression and limit immunotherapy outcomes in PDAC. Overall, we highlight the therapeutic vulnerabilities attributable to immunosuppressive factors and discuss whether targeting these molecular and immunological “hot spots” could improve the outcomes of PDAC immunotherapies.
Stimuli-responsive electrospun nanofibers for drug delivery, cancer therapy, wound dressing, and tissue engineering
Authors: Chen Kai , Li Yonghui , Li Youbin , Tan Yinfeng , Liu Yingshuo , Pan Weisan , Tan Guoxin
Published: July 2023

The stimuli-responsive nanofibers prepared by electrospinning have become an ideal stimuli-responsive material due to their large specific surface area and porosity, which can respond extremely quickly to external environmental incitement. As an intelligent drug delivery platform, stimuli-responsive nanofibers can efficiently load drugs and then be stimulated by specific conditions (light, temperature, magnetic field, ultrasound, pH or ROS, etc.) to achieve slow, on-demand or targeted release, showing great potential in areas such as drug delivery, tumor therapy, wound dressing, and tissue engineering. Therefore, this paper reviews the recent trends of stimuli-responsive electrospun nanofibers as intelligent drug delivery platforms in the field of biomedicine.
Initial validation of the Multidimensional Adolescent Functioning Scale (MAFS) in Spanish-speaking students from Chilean secondary schools
Authors: Núñez Daniel , Villacura-Herrera César , Gaete Jorge , Meza Daniela , Andaur Javiera , Wigman Johanna T.W. , Robinson Jo
Published: July 2023

Introduction

Psychosocial functioning is closely associated with psychopathology and wellbeing in different populations, particularly adolescents. Despite its relevance, measures assessing psychosocial functioning in healthy adolescents are scant as most focus on adults or clinical populations. We evaluated the psychometric properties of the Multidimensional Adolescent Functioning Scale (MAFS), a self-report questionnaire created to assess three dimensions of psychosocial functioning (‘general functioning’, ‘family-related functioning’, and ‘peer-related functioning’) in adolescents from the general population.

Methods

After translation and cultural adaptation, we administered the Spanish MAFS to 619 adolescents aged 14 to 19. We assessed the factor structure, internal consistency, and associations with depressive symptoms, suicidal ideation, cognitive-behavioral skills, cognitive reappraisal (CR), and expressive suppression (ES). We additionally tested for measurement invariance based on biological sex.

Results

The original three-factor structure showed the best fit. Internal consistency was good for the total scale (ω = 0.874; α = 0.869; GLB = 0.939, rM=0.216) and for all subscales (ω = 0.806-0.839; α = 0.769 to 0.812; GLB = 0.861-0.873). Correlations between all three MAFS subscales were significant, ranging between 0.291 and 0.554. All MAFS subscales correlated positively and significantly with cognitive-behavioral skills and adaptive regulatory strategies and negatively with depressive symptoms and suicidal ideation.

Conclusion

The Spanish MAFS translation is a valid and reliable self-report measure to assess three domains of psychosocial functioning in adolescents aged 14–19 from the general population.
Rural research capacity: a co-created model for research success
Authors: Farris Paige , Crist Rachel , Miller Sylvia , Shannon Jackilen
Published: July 2023

Purpose

The United States’ National Institutes of Health (NIH) have long challenged academia to improve clinical trial enrollment, especially in underrepresented populations; inclusive of geography, age, disability status, racial and ethnic minorities. It has been shown that rural and urban residents enrolled in clinical trials have similar outcomes, yet, rural healthcare systems struggle to provide opportunities to rural residents to participate in clinical trials when infrastructure is limited or unsupportive of research programs and/or research staffing levels are insufficient. To fully address the barriers to clinical trial access in rural areas, it is not adequate to simply open more trials. Community receptivity of research as well as organizational and community capacity must be considered. This project was determined by the Oregon Health and Science University’s Institutional Review Board to be generalizable research across the chosen counties and was approved to operate under a waiver of written consent. Participants received a cash incentive in appreciation for their time and verbally agreed to participate after reviewing a project information sheet.

Methods

The research team co-created a community-responsive approach to the receipt, review, and acceptance of clinical trials in a rural community setting. An adapted 5 step Implementation Mapping approach was used to develop a systematic strategy intended to increase the success, and therefore, the number of clinical trials offered in a rural community.

Results

The research team and participating rural community members pilot-tested the implementation of a co-designed research review strategy, inclusive of a Regional Cultural Landscape and three co-created project submission and feasibility review forms, with a cancer early detection clinical trial. The proposed clinical trial required engagement from primary care and oncology. Utilizing the research review strategy demonstrated strong researcher-community stakeholder communication and negotiation, which resulted in early identification and resolution of potential barriers, hiring a local clinical research coordinator, and timely trial opening.

Conclusion

To the knowledge of the research team, the work described is the first to use a community-engaged approach for creating a clinical trial implementation strategy directly supportive of rural-sitting community stakeholders in receiving, reviewing, and approving cancer-related clinical trials in their community. Participating community members and leaders had the chance to negotiate research protocol changes or considerations directly with researchers interested in conducting a cancer clinical trial in their rural setting.
Genetic history of East-Central Europe in the first millennium CE
Authors: Stolarek Ireneusz , Zenczak Michal , Handschuh Luiza , Juras Anna , Marcinkowska-Swojak Malgorzata , Spinek Anna , Dębski Artur , Matla Marzena , Kóčka-Krenz Hanna , Piontek Janusz ,   Polish Archaeogenomics Consortium Team, Figlerowicz Marek
Published: July 2023

Background

The appearance of Slavs in East-Central Europe has been the subject of an over 200-year debate driven by two conflicting hypotheses. The first assumes that Slavs came to the territory of contemporary Poland no earlier than the sixth century CE; the second postulates that they already inhabited this region in the Iron Age (IA). Testing either hypothesis is not trivial given that cremation of the dead was the prevailing custom in Central Europe from the late Bronze Age until the Middle Ages (MA).

Results

To address this problem, we determined the genetic makeup of representatives of the IA Wielbark- and MA Slav-associated cultures from the territory of present-day Poland. The study involved 474 individuals buried in 27 cemeteries. For 197 of them, genome-wide data were obtained. We found close genetic affinities between the IA Wielbark culture-associated individuals and contemporary to them and older northern European populations. Further, we observed that the IA individuals had genetic components which were indispensable to model the MA population.

Conclusions

The collected data suggest that the Wielbark culture-associated IA population was formed by immigrants from the north who entered the region of contemporary Poland most likely at the beginning of the first millennium CE and mixed with autochthons. The presented results are in line with the hypothesis that assumes the genetic continuation between IA and MA periods in East-Central Europe.
Mad2 is dispensable for accurate chromosome segregation but becomes essential when oocytes are subjected to environmental stress
Authors: Qiao Jing-Yi , Zhou Qian , Xu Ke , Yue Wei , Lei Wen-Long , Li Yuan-Yuan , Gu Lin-Jian , Ouyang Ying-Chun , Hou Yi , Schatten Heide , Meng Tie-Gang , Wang Zhen-Bo , Sun Qing-Yuan
Published: July 2023

Accurate chromosome segregation, monitored by the spindle assembly checkpoint (SAC), is crucial for the production of euploid cells. Previous in vitro studies by us and others showed that Mad2, a core member of the SAC, performs a checkpoint function in oocyte meiosis. Here, through an oocyte-specific knockout approach in mouse, we reconfirmed that Mad2-deficient oocytes exhibit an accelerated metaphase-to-anaphase transition caused by premature degradation of securin and cyclin B1 and subsequent activation of separase in meiosis I. However, it was surprising that the knockout mice were completely fertile and the resulting oocytes were euploid. In the absence of Mad2, other SAC proteins, including BubR1, Bub3 and Mad1, were normally recruited to the kinetochores, which likely explains the balanced chromosome separation. Further studies showed that the chromosome separation in Mad2-null oocytes was particularly sensitive to environmental changes and, when matured in vitro, showed chromosome misalignment, lagging chromosomes, and aneuploidy with premature separation of sister chromatids, which was exacerbated at a lower temperature. We reveal for the first time that Mad2 is dispensable for proper chromosome segregation but acts to mitigate environmental stress in meiotic oocytes.
Το ομιλητικό έργο του Διονυσίου Λάτα
Authors: Μανδραπήλιας Αναστάσιος
Published: July 2023

Η διδακτορική αυτή διατριβή πραγματεύεται την ζωή και το ομιλητικό έργο του Αρχιεπισκόπου Ζακύνθου Διονυσίου Λάτα, ο οποίος έζησε και ιερούργησε κατά τον 19ο αιώνα υπηρετώντας την Εκκλησία της Ελλάδος και την Ορθοδοξία, αφήνοντας ως παρακαταθήκη ένα αξιόλογο πνευματικό, ρητορικό και επισκοπικό έργο και ο οποίος υπήρξε μία από τις εξέχουσες μορφές του Ελληνικού Κλήρου.
Διερεύνηση της ποικιλίας στην έκφραση των café-au-lait κηλίδων σε παιδιά με νευροϊνωμάτωση τύπου 1 και συσχέτιση με τον γονότυπο
Authors: Νάση Λαμπρινή
Published: July 2023

Οι Cafe-au-lait κηλίδες (CALMs) είναι το πιο χαρακτηριστικό κλινικό εύρημα στη Νευροϊνωμάτωση τύπου Ι (NF1). Στόχος: Να περιγράψουμε σε μια προοπτική μελέτη κοορτής σε Ελληνόπουλα με τη διάγνωση της NF1 τον δερματολογικό τους φαινότυπο και να αναλύσουμε τα χαρακτηριστικά των CALMs και τη συσχέτισή τους με τον γονότυπο . Μέθοδοι: Η ένταση της χρωστικής και η περιεκτικότητα σε μελανίνη των CALM μετρήθηκαν με φασματοφωτόμετρο στενής ζώνης. Αποτελέσματα: Μελετήθηκαν εξήντα τρία παιδιά ηλικίας 6 μηνών έως 16 ετών. Η μέση περιεκτικότητα σε μελανίνη ήταν διαφορετική τόσο μεταξύ των ασθενών όσο και σε κάθε ασθενή (p<0,001). Τα κορίτσια εμφάνισαν μεγαλύτερο αριθμό CALM από τα αγόρια (p = 0,025) και η περιεκτικότητα σε μελανίνη των CALMs ήταν χαμηλότερη στα κορίτσια (p <0,001). Οι ασθενείς με παραλλαγές περικοπής πρωτεΐνης στο γονίδιο NF1 είχαν υψηλότερη περιεκτικότητα σε μελανίνη στις CALMs σε σχέση με τους άλλους τύπους γενετικών παραλλαγών t (55) = 2,196, p = 0,032. Επιπλέον, πλεγματοειδή νευροϊνώματα ανιχνεύθηκαν στην πλειονότητα των ασθενών με παραλλαγές περικοπής πρωτεΐνης, ενώ νεανικά ξανθοκοκκιώματα ανιχνεύθηκαν εξίσου σε ασθενείς με πρωτεϊνικές και μη πρωτεϊνικές παραλλαγές πρωτεΐνης. Συμπεράσματα: Συμπερασματικά, οι CALMs με υψηλή περιεκτικότητα σε μελανίνη σχετίζονται με ασθενείς που φέρουν παραλλαγές που δεν περικόπτουν την πρωτεΐνη. Επομένως, η μέτρηση της έντασης της χρωστικής των CALMs θα μπορούσε ενδεχομένως να παρέχει χρήσιμες πληροφορίες για την αρχική αξιολόγηση ασθενών με NF1 και την πρόβλεψη της σοβαρότητας του μελλοντικού φαινοτύπου τους.
Cognitive control, theory of mind and memory
Authors: Τσεντίδου Γλυκερία
Published: July 2023

Ένα από τα βασικά ερευνητικά ενδιαφέροντα των τελευταίων ετών, το οποίο μάλιστα βρίσκει άμεση σχέση με την κλινική πράξη, είναι το θέμα της νόσου Alzheimer (AD) και της αγγειακής παθολογίας. Η παρούσα διδακτορική διατριβή έχει ως κεντρικό θέμα την αξιολόγηση τριών βασικών συνιστωσών της γνωστικής λειτουργίας, δηλαδή των εκτελεστικών λειτουργιών, της μνήμης και της Θεωρίας του Νου, οι οποίες εκπίπτουν στη νόσο Alzheimer (AD) και στην αγγειακή παθολογία. Σκοπός της μελέτης ήταν να εξεταστούν τα στοιχεία της γνωστικής λειτουργίας σε δύο παθολογικές ομάδες, συγκρίνοντάς τα με μια υγιή ομάδα ελέγχου, ώστε (α) να κατανοηθούν οι διαφοροποιήσεις τους στη γνωστική έκπτωση και (β) να αναπτυχθούν συγκεκριμένες συντομες συστοιχίες που μπορούν να βοηθήσουν στην έγκαιρη διάγνωση γνωστικής έκπτωσης. Συγκεκριμένα, οι δύο παθολογικές ομάδες αποτελούνταν από ενήλικες (άνω των 58 ετών) με παράγοντες αγγειακού κινδύνου, ενώ η μία ομάδα είχε επιπλέον διάγνωση Ήπιας Γνωσιακής Εξασθένησης. Η μελέτη είχε δύο φάσεις, τη συγχρονική και τη διαχρονική. Χρησιμοποιήθηκαν ANOVA, MANOVA και μικτές μέθοδοι για την εξέταση και σύγκριση της απόδοσης των τριών ομάδων σε όλες τις μεταβλητές καθώς και της διαχρονικής διακύμανσης των μεταβλητών σε κάθε ομάδα. Η ανάλυση διαμεσολάβησης χρησιμοποιήθηκε επίσης για την εξέταση πιθανών σχέσεων μεταξύ συγκεκριμένων μεταβλητών ενδιαφέροντος. Συγκεκριμένα, ο στόχος της συγχρονικής αξιολόγησης ήταν να αποκαλύψει τις διαφορές μεταξύ της απόδοσης των ομάδων μελέτης και του προτύπου των δυσκολιών που παρουσιάστηκαν σε κάθε ομάδα. Ενώ για το διαχρονικό μέρος, στόχος ήταν η αξιολόγηση των μεταβλητών σε τρία χρονικά σημεία, η διερεύνηση των αλλαγών τους εντός και μεταξύ των ομάδων, ώστε να αποκαλυφθεί ένα μοτίβο δυνητικά διαφορετικής γνωστικής έκπτωσης για κάθε μία από τις παθολογικές ομάδες. Η χρησιμότητα της μελέτης έγκειται στην πρόταση συγκεκριμένων εργαλείων που είναι χρήσιμα τόσο στη διάγνωση των δύο παθολογιών όσο και στην αξιολόγηση της μετάβασης από τη μια παθολογική κατηγορία στην άλλη.
Precoder Based Transceivers Design for Non-Orthogonal Multiple Access Mixed Numerologies
Authors: P. Kumar , Rani K.R. Usha
Published: July 2023

Orthogonal Frequency Division Multiplexing (OFDM) based mixed numerology scheme and Non-Orthogonal Multiple Access (NOMA) are the two important key features of 5G radio standard capable of handling diversified service requirements. However, the mixed numerology scheme suffers from an inherent problem called Inter Numerology Interference (INI) that arises due to non-orthogonality issue between any two numerologies, whereas NOMA suffers from potential Bit Error Rate (BER). In this research work, transmitter architecture based on windowing and pre-coding techniques to mitigate the INI and two receiver architectures based on the principle of Successive Interference Cancellation (SIC) and Combined Maximum Likelihood (CDML) decoding are proposed for optimal decoding of the information. The proposed system model is designed to operate under mixed numerology NOMA scenario. The BER performance analysis is done for both the receivers and compared with each other and the conclusive remarks are drawn.
Fuzzy Tree Schematic for Spectrum Handoff Reduction in Cognitive Radio Networks
Authors: Dadi Riskiono Sampurna , Sulistiyo Selo , Mustika I Wayan
Published: July 2023

Spectrum is a limited resource, so it must be used effectively. The fixed spectrum allocation method currently in operation may not sustain the growth in the network access users, which continues to increase over time. Many studies have shown that the spectrum deficiency problem can be solved with cognitive radio network (CRN) technology. CRN allows flexible spectrum utilization. Spectrum handoff is one of the fundamental prerequisites for dynamic spectrum access in cognitive radio networks. The ping-pong effect is one of the problems caused by the frequent occurrence of unnecessary handoff spectrum. So, in CRN, the right handoff decision is needed to avoid the ping-pong effect. The proposed fuzzy system carries the concept of a fuzzy tree that uses two fuzzy inference systems (FIS), which work in two stages, namely FIS-1 and FIS-2. In the early stages, the FIS-1 controls the secondary users (SU) power and prevents interference with the primary users (PU). FIS-2 is used to execute precise spectrum handoff decisions. The test results show that the amount of handoff spectrum has decreased by up to 43 % compared to other methods, which are only 60 %. This results in a decrease of 16.67% from the previous method. Thus, the ping-pong effect can be minimized with the right handoff decisions.
History, membership and activity of the Roman collegia dendrophorum. Outline of the problem.
Authors: Wojciechowski Przemysław
Published: July 2023

The aim of this article is to outline the research problem of reconstructing the history, social structure and functions of one of the most popular private associations in ancient Rome, namely collegia dendrophorum. The article consists of two parts. The first presents the main directions of research on Roman private colleges, with particular emphasis on the dendrophori; the state of research on the colleges of interest to us was discussed and research possibilities in this area were indicated. In the second part, the methodology of research on Roman colleges is the subject of analysis. The current state of the source database and research limitations resulting from its specificity were presented.
Obrazy w mieszczańskich inwentarzach pośmiertnych z terenu Małopolski (XVI–XVIII w.)
Authors: Justyniarska-Chojak Katarzyna
Published: July 2023

W inwentarzach pośmiertnych spisanych w małopolskich miasteczkach na przestrzeni XVI–XVIII wieku obrazy lub przedmioty rzemiosła artystycznego występowały rzadko i nie zajmowały w hierarchii przedmiotów szczególnie eksponowanego miejsca. Warto je jednak odnotować, ponieważ ich obecność w rejestrach może wskazywać na istnienie wśród mieszczan pewnych potrzeb natury estetycznej czy chęć podkreślenia pozycji społecznej. W tym kontekście zdziwienie może budzić tak ograniczony udział obrazów wśród spisywanych ruchomości. Takie zjawisko możemy tłumaczyć nie tylko ograniczeniami natury ekonomicznej, ale i mentalnej – wynikającej z poziomu wykształcenia mieszczan i ich ograniczonego obycia ze sztuką.
„Chłop bez oświaty jest prawdziwym kołkiem w płocie” .
Authors: Hoszowska Mariola
Published: July 2023

Macierz Polska we Lwowie powstała w 1882 r. z inicjatywy Józefa Ignacego Kraszewskiego i była z jedną z najważniejszych galicyjskich fundacji wydawniczych nastawionych na edukację warstw plebejskich. Współpracował z nią wykształcony na Uniwersytecie Lwowskim i związany z Akademią Umiejętności w Krakowie oraz Uniwersytetem Jagiellońskim historyk i badacz dziejów Polski XVII stulecia, Wiktor Czermak (1863-1913). Spośród kilku opracowań przeznaczonych dla MP najwyższy poziom prezentowała rocznicowa praca o bitwie grunwaldzkiej, w której wybrzmiało przekonanie, iż Grunwald przyczynił się do umocnienia unii polsko-litewskiej i przyniósł w XV w. kolejne wielkie zwycięstwo nad Krzyżakami. Uczony sympatyzując z poglądami krakowskiej szkoły historycznej, potem narodowej demokracji, wysuwał na plan pierwszy dokonania wybitnych wodzów. Sięgał po zróżnicowane sposoby opowiadania o wydarzeniach przeszłości. Długa współpraca z Macierzą była wynikiem przeświadczenia o roli popularyzacji wiedzy w podnoszeniu kultury historycznej społeczeństwa. Przekonaniu wpojonemu przez mistrza K. Liskego uczeń pozostał wierny do końca życia. Jego twórczość potwierdza zarazem wysoką pozycję historii i historyków w społeczeństwie polskim przełomu XIX i XX w.
Oczami kobiet – „Mój sierpień ’80. Pamiętne lato” i „Mój sierpień „80” – źródła do badań nad historią wydarzeń Grudnia’ 70 oraz strajku Stoczni Gdańskiej w 1980 r.
Authors: Kosk Barbara
Published: July 2023

Prezentowany tekst stanowi edycję źródeł zatytułowanych „Mój sierpień ’80. Pamiętne lato” oraz  „Mój Sierpień „80”. Powyższe materiały nadesłano na konkurs zorganizowany w 1981 roku przez Oddział Gdański Polskiego Towarzystwa Socjologicznego poświęcony relacjom z protestu, który wybuchł na Wybrzeżu latem 1980 roku. Edycji dokonano na podstawie instrukcji wydawniczej Janusza Tandeckiego oraz Krzysztofa Kopińskiego pod tytułem „Edytorstwo źródeł historycznych”. Tekst opatrzono wstępem, w którym przedstawiono najważniejsze informacje dotyczące sierpniowej fali sprzeciwu. Cel prezentowanych edycji stanowi ukazanie wspomnień Haliny Pawłowskiej oraz Marty Wiśniewskiej, które stanowią źródło do badań nad historią wydarzeń Grudnia ’70 i strajku sierpniowego. Przedstawione relacje, widziane w perspektywie kobiet przybyłych na Wybrzeże ze stolicy kraju, ukazują odmienne niż powszechnie prezentowane w literaturze przedmiotu spojrzenie na wydarzenia mające miejsce w Trójmieście.
O metodzie pisania dziejów starożytnego Izraela/Żydów w starożytności
Authors: Niesiołowski-Spano Łukasz , Stebnicka Krystyna
Published: July 2023

Polemika z recenzją Piotra Briksa i Witolda Tyborowskiego, któa ukazała się w „Klio. Czasopismo poświęcone dziejomPolski i powszechnym” 2022, t. 64 (4), s. 171–193.
Przemysław Benken i Robert Borucki, Wojewódzki Komitet Obywatelski "Solidarność" w Koszalinie w 1989 roku. Edycja źródłowa, Koszalin-Szczecin 2020, Instytut Pamięci Narodowej-Oddział w Szczecinie i Archiwum Państwowe w Koszalinie, ss. 408.
Authors: Krawcewicz Arkadiusz
Published: July 2023

Recenzja dotyczy pracy autorstwa Przemysława Benkena i Roberta Boruckiego pt. Wojewódzki Komitet Obywatelski "Solidarność" w Koszalinie w 1989 roku. Edycja źródłowa, Koszalin-Szczecin 2020. Autorzy przeanalizowali przebieg kampanii wyborczej na terenie województwa koszalińskiego do Sejmu X kadencji Polskiej Rzeczypospolitej Ludowej i Senatu I kadencji w wyborach czerwcowych 1989 r., które odbyły się w wyniku porozumień Okrągłego Stołu. Przedstawiono działania podejmowane w trakcie kampanii przez uczestniczące strony: "Solidarność" oraz stronę rządową (reprezentowaną głównie przez Polską Zjednoczoną Partię Robotniczą). Przedstawiono działania prowadzone przez Służbę Bezpieczeństwa w ramach sprawy obiektowej "Parawan" na terenie województwa koszalińskiego w 1989 r.
Popularization of Slovak Folk Tales in Poland
Authors: Smolińska Teresa
Published: July 2023

The reflection about research on Slavic folklore must be accompanied by a careful reminder that in the 19th century many people showed general interest in it and carried out field studies: these were amateurs, travellers, journalists and professional gatherers, i.e. ethnologists, and in the 20th century – folklorists (who continued the earlier work following accepted scientific curricula). The close linguistic affinity of the Slavs, similarity of political situations and social structures of folklore depositaries throughout history facilitated and developed comparative research on various folklore genres (tales, songs, legends, proverbs, comic stories). In the 19th century, Slovak songs were distinguished by Oskar Kolberg. Conversely, a concrete example of pioneering academic achievements in folk tale studies in Slovakia includes the tales collected by Pavol Dobšinský and Samuel Czambel, and later (in the first half of the 20th century) by Frank Wollman and his followers; and after World War II – by Viera Gašpariková. Many integrative, interethnic and comparative research initiatives have been directly linked to the tales and resulted in printing valuable collections of texts edited by folklorists from Poland and Slovakia e.g. Śpiewająca lipka. Bajki Słowian Zachodnich (The Singing Linden Tree. The Tales of the West Slavs), Zbójnicki dar. Polskie i słowackie opowiadania tatrzańskie (The Robber’s Gift. Polish and Slovak Stories about the Tatras), Słoneczny koń. Bajki słowackie (The Sunny Horse. Slovak Tales), Skarb w garncu. Humor ludowy Słowian Zachodnich (The Treasure in the Pot. Folk Humour of the West Slavs), Bajki słowackie (Slovak Tales by P. Dobšinský). According to the author of the article, Polish and Slovak work in the field of tales stands out among the research on folklore genealogy of the Slavs. Therefore, she focuses on the anthologies that promote and popularize Slovak tales in Poland.
On Some Selected Slavic Motifs of the Collection Klechdy, starożytne podania i powieści ludu polskiego i Rusi by Kazimierz Władysław Wójcicki
Authors: Ajdačić Dejan
Published: July 2023

The two-volume collection of Klechdy, starożytne podania i powieści ludu polskiego i Rusi (Fables: Ancient Legend and Folk Narratives of Poland and Russia) by Kazimierz Władysław Wójcicki, a writer and popularizer of folk tales, aroused interest in Poland and among lovers of Slavic folk culture. K. W. Wójcicki wrote his book in the 1830s, in an era of strong Slavophile sentiments and under the influence of Polish Romantics from Lviv. The author mentions earlier research by Julian Krzyżanowski, Julian Maślanka, Ryszard Wojciechowski and Violetta Wróblewska concerning the collection Klechdy, starożytne podania i powieści ludu polskiego i Rusi. In fairy tales in the collection by K. W. Wójcicki, apart from motifs and content from the Polish folk tradition, there are elements from other Slavic traditions. The author analyzes the presence of Serbian, Slovak and Ukrainian motifs, pointing to the sources, methods of Polonization and the author’s stylization of Slavic folkloric motifs.
Wiesław, or a Slavic Magical Fairy Tale as Comic Book Material
Authors: Gołębiowska-Suchorska Agnieszka
Published: July 2023

The article will present the results of a literary analysis of the comic book Wiesław by Maciej Kisiel (3 parts, 2019–2022), which is based on Slavic fairy tales. The inspiration for the analysis of the comic was Jolanta Ługowska’s reflections on the folk magic fairy tale as material of fiction. Folk material functions as a potential source of literary plots and comic scripts from which the author can draw the idea of the plot or even individual motifs or characters to be freely contaminated and modernised. The aim of the reflections on the phenomenon of comic transposition of motifs of Slavic folk tales was to determine to what extent the principles of constructing the plot of the analysed comic correspond to the principles of constructing a folk tale (economy of means, expressive exposition of turning points, covering the perspective of the narrator and the protagonist); and what adaptation and transformation processes (threads, motifs, heroes, objects) serve to adapt folklore material to the new communication situation and recipient.
On Working on Współczesny bajarz polski
Authors: Zuzanna Orlińska
Published: July 2023

Zuzanna Orlińska - illustrator, author of texts for children and teenagers, among others, Ładna historia (A Nice Story, 2022), Okna Pałacu Saskiego (Windows of the Saxon Palace, 2022), Współczesny bajarz polski (A Contemporary Collection of Polish Folk Tales, 2021), Wstydu za grosz (No Shame, 2020), Miasto pamięci (A City of Memory, 2020), Matka Polka (Polish Mother, 2017), Ani słowa o Zosi (Not a Wordabout Zosia, 2020). She has received many awards and distinctions, including the “Guliwer w Krainie Olbrzymów” Award, the Kornel Makuszyński Literary Award and the award in the Astrid Lindgren Literary Competition
From Research on the Mythology of the Slavs
Authors: Kowalski Andrzej P.
Published: July 2023

Review: Michał Łuczyński, Mity Słowian. Śladami świętych opowieści przodków, Triglav, Szczecin 2022.
Paisajes del inframundo. La leyenda del agua de la vida en la Novela de Alejandro.
Authors: Jiménez Cid, Alejandro
Published: July 2023

Las narrativas de Alejandro y el agua de la vida cumplen una doble función: por una parte, ilustrar la ambición y desmesura de su protagonista; por otra, representar el entorno donde se encuentra la fuente de la inmortalidad conforme a las concepciones vigentes del más allá: una región envuelta en tinieblas, situada en los márgenes de la realidad. Valiéndose de un enfoque abierto e interdisciplinar, el presente trabajo sigue el recorrido de los distintos elementos que, procedentes de las tradiciones más diversas, se fueron sedimentando a lo largo de los siglos en esta singular construcción del inframundo codificada en el mito de Alejandro. La obra presenta las primeras traducciones al castellano de estos pasajes, versiones directas de los originales persas: las pertenecientes al S?a¯hna¯mé de Ferdo¯sí (1010) y al S?arafna¯mé de Nez?a¯mí de Gany^é (1200).