bluuebunny/crossref_metadata_2025 huggingface dataset:
Correlation of Handedness with Hand Shape Index in Right Hander and Left Hander Medical Students of Bangladesh
Authors: Rahman Md Shamsur , Gulshan Ara Zubaida , Ara Anjuman , Parveen Rehana , Momena Zeenatul , Parven Irin , Begum Taslima
Published: June 2022

This cross-sectional, analytical type of study was performed in Department of Anatomy, Dhaka Medical College, Bangladesh, from July 2016 to June 2017 on 52 right hander male and 52 right hander female, 40 left hander male and 34 left hander female Bangladeshi medical students. Convenient purposive sampling technique was adopted. History of any injury of upper limb was excluded to construct standard measurement. Handedness of each medical student was determined by the Edinburgh handedness inventory. Hand breadth and hand length was measured with the help of vernier caliper. Paired and unpaired student‟s „t‟ test and Pearson‟s correlation coefficient test were done for statistical analyses. Handedness score showed nonsignificant positive correlation with right hand shape index (r = +0.087, P>0.05) and left-hand shape index (r = +0.008, P>0.05) in right hander males. Handedness score showed non-significant negative correlation with right hand shape index (r = -0.017, P>0.05) and left-hand shape index (r = -0.003, P>0.05) in right hander females. Handedness score showed non-significant negative correlation with right hand shape index (r= - 0.210, P>0.05) and left-hand shape index (r = -0.247, P>0.05) in left hander males. Handedness score showed non-significant positive correlation with right hand shape index (r= +0.051, P>0.05) and left-hand shape index (r = +0.213, P>0.05) in left hander females. To summarize, handedness score showed nonsignificant positive correlation with right hand shape index and left-hand shape index in right hander males and left hander females. However, handedness score showed non-significant negative correlation with right hand shape index and left-hand shape index in right hander females and left hander males.

CBMJ 2022 January: vol. 11 no. 01 P: 14-20
Assessment of Renal and Liver Function Tests Before and After Induction of Chemotherapy in Newly Diagnosed Acute Lymphoblastic Leukemia in Children
Authors: Chowdhury Sayla , Islam Afiqul , Sultana Mahbuba , Mostafiz Mir Iftekhar
Published: June 2022

A prospective study was done in the Department of Paediatric Hematology & Oncology of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, between January and June of 2012, to observe the renal and liver function status in children suffering from acute lymphoblastic leukemia (ALL) before and after induction of chemotherapy. A total of 30 diagnosed patients of acute lymphoblastic leukemia were enrolled in the study. Renal and liver function tests were done before and after induction of chemotherapy. All the patients of the study were within 2-11 years range. Mean age was 5.12±2.53 years. Maximum 43.3% patients were within 3-6 years of age followed by 33.3% up to 3 years of age,13.3% within 6-9 year of age range and 10% above 9-year age range. 73.3% were male and 26.7% were female. Among the liver functions tests, mean bilirubin level of the patients before induction of chemotherapy was 2.31±4.71 mg/dl and after induction of chemotherapy was 1.12±2.15 mg/dl (P=0.122). Mean SGPT levels were 35.33±15.82 IU/L and 75±57.12 IU/l respectively (P=0.001). Mean total protein levels were 67.05±6.99 gm/dl and 64.47±7.51 gm/dl respectively (P=0.06). All the patients were HBsAg negative. Among the renal function tests, mean blood urea level of the respondents before induction was 28.89±7.95 mg/dl and after induction was 30.67±9.39 mg/dl (P=0.429). Mean serum uric acid levels were 4.63±1.18 mg/dl and 5.12±0.44 mg/dl respectively (P=0.044). Mean serum creatinine levels were 0.74±0.27 mg/dl and 0.67±0.22 mg/dl respectively (P=0.168). Mean GFR was 99.77±37.38 ml/1.732/min. before induction of chemotherapy and 108.57±37.29 ml/1.732/min. following chemotherapy (P=0.177). Kidney and liver functions may be affected in ALL in children. Recognition of hepatic and renal impairment at the onset of illness helps judicious chemotherapy in management of ALL.

CBMJ 2022 January: vol. 11 no. 01 P: 21-26
КОНТРОЛЬ ТА ОЦІНЮВАННЯ СТАНУ ПІДШИПНИКІВ СУДНОВОГО ВАЛОПРОВОДУ
Authors: Сорокін В.В.
Published: June 2022

Розглянуті пошкодження і відмови суднових валопроводів (ВП)та підшипників кочення йковзання, а так само причини, які їх викликають. Були розглянуті навантаження, що впливають на ВП у процесі роботи, через які утворюються дефекти. Відомо, що половина від усіх видів напруг, які виникають у ВП, складає такий вид напруженого стану як обертання. Усі обертальні коливання, виникаючі у валопроводах носять знакоперемінний характер і обумовлені дією періодичних сил від кривошипів колінчатого вала і лопатей гвинта, які викликають закручування і розкручування окремих мас. Поперечні коливання з'являються в результаті дисбалансу, обумовленого ексцентриситетом мас роторів та їх сполучних елементів при експлуатації та ремонті. У результаті проведеного аналізу причин дефектів та пошкоджень суднових ВП був зроблений наступний висновок: пошкодження суднових ВП викликає напружено-деформований стан в елементах підшипників. Технічний стан валової лінії СЕУ визначається в основному ресурсом підшипників.Для запобігання аварійного виходу з ладу судна, були розглянуті причини, які приводять до пошкоджень і виходу з ладу підшипників ВП. Виявлено основні фактори, які визначають умови експлуатації підшипників ВП. Визначено процеси, які призводять до важких задирам, або катастрофічному зносу та виходу з ладу підшипників ВП.Ключові слова: валопровід, вібродіагностика, двигун внутрішнього згоряння, підшипник, морський транспорт.
КОНЦЕПТУАЛЬНО-ТЕОРЕТИЧНІ ЗАСАДИ МІЖНАРОДНОГО МОРСЬКОГО ПРАВА
Authors: Зазірний А.А. , Ганношина І.М. , Майданевич С.Б.
Published: June 2022

В статті розкрито зміст і сутність Міжнародного морського права як однієї з найважливіших галузей Міжнародного права, яка координує суспільні відносини в сфері використання вод і ресурсного потенціалу Світового океану. Розглянуто процес кодифікації Міжнародного морського права, як окремої галузі Міжнародного права, визначено найважливіші міжнародні договори та угоди, яких дотримуються суб’єкти права в процесі здійснення морської діяльності. Визначено сутність таких понять, як «суб’єкт права», «об’єкт права», «внутрішньодержавне (національне) морське право», «міжнародне морське публічнеправо», «міжнародне морське приватне право». Вказано основні структурні елементи, характерні риси, підсистеми та функції Міжнародного морського права. Досліджуючи суб’єктний склад морського права авторка дотримуються тези про те, що головним суб’єктом Міжнародного права виступають саме держави.Проаналізовано складну систему юридичних норм і принципів Міжнародного морського права, визначено їх основні види та специфіку реалізації. Встановлено, що особливістю регулювання правовідносин між суб’єктами морського права є поєднання міжнародних та звичаєвих норм. Зазначено, що міжнародні відносини в сфері експлуатації Світового океану здійснюються з дотриманням, як загальних принципів Міжнародного права, так і спеціальних (галузевих) принципів Міжнародного морського права. Їх основні положення зводяться до стабілізації та налагодження міжнародних відносин в сфері використання морських просторів, рівноправ’я всіх суб’єктів права, поваги до прав людини та визнання за народами права на самовизначення, невтручання у внутрішні справи держави, недоторканість кордонів і територіальної цілісності кожної країни, мирне регулювання міждержавних конфліктів і протиріч, які виникають в процесі морської діяльності тощо.Ключові слова:морське право, суб’єкти права, об’єкти права,принципи, норми, конвенція, міжнародний договір, міжнародна угода.
Mechanism, clinical consequences, and management of dyslipidemia in children with nephrotic syndrome
Authors: Baek Hee Sun
Published: June 2022

Dyslipidemia in nephrotic syndrome (NS) is often characterized by marked increases in the levels of total cholesterol, triglycerides, low-density lipoprotein cholesterol, and other lipoproteins, such as very low-density lipoprotein, intermediate-density lipoprotein, and lipoprotein(a). It has been suggested that impaired catabolism of lipoproteins and cholesterol is mainly due to decreased lipoprotein lipase and hepatic lipase activity, and increased biosynthesis of lipoproteins in the liver. The management strategies for dyslipidemia in patients with NS consist of lifestyle modification, lipid-lowering agents represented by statins, second-line agents such as fibrates and bile acid sequestrants, and lipid apheresis. Compared with dyslipidemia in adult NS patients, whose risks of atherosclerotic disease and progressive renal injury are considered high, clinical data on dyslipidemia in pediatric NS patients are limited. Therefore, it is necessary to pay more attention to the evaluation and management of dyslipidemia in pediatric patients with NS in clinical practice.
Management strategies for congenital isolated hydronephrosis and the natural course of the disease
Authors: Jung Jiwon , Lee Joo Hoon , Kim Kun Suk , Song Sang Hun , Moon Dae Hyuk , Yoon Hee Mang , Cho Young Ah , Park Young Seo
Published: June 2022

Congenital isolated hydronephrosis encompasses a spectrum of physiologic states that spontaneously resolve and pathologic obstruction that necessitates surgical intervention. Distinguishing patients whose condition will resolve, those who will require stringent follow-up, and those who will eventually need surgical intervention present a challenge to clinicians, particularly because no unified guidelines for assessment and follow-up have been established. The recognition of the natural course and prognosis of hydronephrosis and a comprehensive understanding of the currently proposed consensus guidelines may aid in multidisciplinary treatment and in providing proper counseling to caregivers. In this review, we aimed to summarize the literature on the grading systems and management strategies for congenital isolated hydronephrosis.
Impacto da recaída do uso de substâncias psicoativas na perspectiva de mulheres usuárias
Authors: Soccol Keity Laís Siepmann , Terra Marlene Gomes , Tisott Zaira Letícia , Ferreira Carla Lizandra de Lima , Wasum Fernanda Demetrio , Soliz Paola Piovenzano de , Silveira Júlia Oliveira , Siqueira Daiana Foggiato de
Published: June 2022

Objetivo: compreender o impacto da recaída do uso de substâncias psicoativas na perspectiva das mulheres. Materiais e métodos: pesquisa qualitativa realizada com 20 mulheres usuárias de substâncias psicoativas em tratamento em um Centro de Atenção Psicossocial de um município do estado do Rio Grande do Sul (Brasil). Foram realizadas entrevistas individuais e abertas entre fevereiro e maio de 2017, que foram objeto de análise temática. Resultados: a recaída interfere nas relações familiares e sociais, fragilizando os laços afetivos, causando prejuízos na rotina e nas atividades cotidianas devido aos efeitos do uso de substâncias e exacerbando sentimentos negativos nas mulheres a cada recaída, como culpa, frustração e desamparo. Conclusão: é necessário um cuidado único e integral que contemple as necessidades de saúde e sociais derivadas das consequências da recaída na vida das mulheres. Da mesma forma, destaca-se a necessidade de trabalhar as questões de gênero durante o atendimento à mulher.
Relação entre catastrofização da dor e capacidade funcional de mulheres com osteoartrite de joelho: um estudo transversal
Authors: Silva Karine Davino da , Maia Thaís  Ferreira Lopes Diniz , Alves Laura Izabel do Nascimento , Barros Polianna Tavares de , Oliveira Franciele Borges de , Pessôa Karen Mirelly do Nascimento , Siqueira Gisela Rocha de , Oliveira Daniella Araújo de , Tenório Angélica da Silva
Published: June 2022

A osteoartrite de joelho tem como principal sintoma a dor. A catastrofização é um fator cognitivo que pode influenciar a sensação dolorosa. O objetivo deste estudo foi avaliar a presença de catastrofização da dor em mulheres com osteoartrite de joelho e a relação da catastrofização com a capacidade funcional, dor, qualidade de vida e mobilidade articular. A amostra foi composta por mulheres com idade de 50 a 80 anos, com osteoartrite de joelho. Foram avaliados: Catastrofização [Pain Catastrofizing Scale (PCS)]; Capacidade funcional [Testes: Sentar-levantar da cadeira; Caminhada de 40m; Subir-descer degraus]; Qualidade de vida [Western Ontário and McMaster Universities Questionnaire (WOMAC) e Medical Outcomes Study 36 – Item Short – Form Health Survey (SF-36)] e mobilidade articular do joelho [goniometria]. Conforme o resultado da PCS, dividiu-se a amostra nos grupos GCC (Com catastrofização) (n=10) e GSC (Sem catastrofização) (n=23). Realizou-se análise de média e desvio-padrão, Teste de Shapiro-Wilk, Teste t de Student ou U de Mann–Whitney e Correlação de Spearman. Considerou-se p<0,05 e IC95%. A amostra foi composta por 33 mulheres, 30,30% apresentaram catastrofização (PCS ≥ 30). O GCC apresentou menor pontuação no WOMAC e maior escore no SF-36 (p<0,05), exceto no domínio aspectos sociais. A catastrofização apresentou correlação significativa com os testes de Sentar-levantar da cadeira e Subir-descer degraus; com o WOMAC e com a maioria das categorias do SF-36. Os resultados sugerem que a catastrofização está relacionada com menor capacidade funcional, pior intensidade da dor e qualidade de vida em mulheres com gonartrose.
PERANCANGAN SISTEM VIRTUAL LABORATORY PRAKTIKUM RESPIRASI KELAS INSEKTA PADA SMA NEGERI 98 JAKARTA
Authors: Amini Azizah Nur , Darono Hanafi Eko
Published: June 2022

Dalam dunia pendidikan, e-learning dan virtual laboratorium menjadi bentuk penyesuaian terhadap perkembangan sistem informasi yang ada. SMA Negeri 98 Jakarta membutuhkan adanya suatu sistem informasi yang dapat menunjang kegiatan belajar mengajar. Untuk itulah penulis membangun perancangan sistem virtual lab di SMA Negeri 98 Jakarta khususnya pada mata pelajaran biologi praktikum respincarasi kelas insekta. Pada saat ini, SMA Negeri 98 Jakarta masih terkendala dalam penggunaan ruang laboratorium, dimana hanya ada satu ruangan dan tidak adanya laboran yang mengatur jadwal penggunaan ruang laboratorium. Selain itu, siswa juga dinilai masih kurang memahami cara kerja dan penggunaan alat praktikum. Pembuatan rancangan sistem virtual laboratory sebagai solusi yang terbaik ini menggunakan metode penelitian dan pengembangan sistem evolutionary prototype dimana tahapan ini melalui analisa kebutuhan user, pembuatan, penyesuaian dan penggunaan prototype. Hasil pembuatan perancangan sistem ini bertujuan untuk menjadi bahan referensi SMA Negeri 98 Jakarta untuk membuat sistem virtual laboratory agar kegiatan praktikum dapat berjalan dengan efisien dan efektif.
OPTIMASI ALGORITMA C4.5 MENGGUNAKAN ALGORITMA GENETIKA UNTUK PREDIKSI PENYAKIT HEPATITIS
Authors: Septiani Wisti Dwi
Published: June 2022

Hepatitis is an infectious disease which is a public health problem that affects morbidity, mortality, public health status, life expectancy, and other socio-economic impacts. Hepatitis is inflammation of the liver that can increase into liver cancer. The most common causes of hepatitis are those caused by hepatitis B and C viruses. Previous research used the data mining classification method C.45 algorithm and showed an accuracy rate of 77.29%. The purpose of this study is to improve the accuracy of the C.45 algorithm by optimization using genetic algorithm. The results of this further research are the decision tree and an increase in the accuracy rate of 12.42% from 77.29% to 89.71%.
SISTEM INFORMASI PENCARIAN RUMAH KOST BERBASIS WEB
Authors: Yusma Destiana , Merlina Nita , Nurajijah Nurajijah
Published: June 2022

Rumah kost dibutuhkan sebagian kelompok masyarakat sebagai tempat tinggal sementara dengan sistem pembayaran periodik. Pencarian rumah kost secara konvensional dengan bertanya kepada masyarakat membutuhkan waktu yang lama untuk mendapatkan hunian dengan spesifikasi yang diinginkan, Tujuan penelitian ini adalah menghasilkan sistem dengan akses cepat dan akurat untuk pencarian maupun promosi rumah kost. Metode penelitian yang digunakan adalah observasi secara langsung dan pengembangan sistem menggunakan metode waterfall. Sistem informasi pencarian rumah kost berbasis web dapat mempermudah user dalam melakukan pencarian dan penyewaan tanpa harus datang langsung ke lokasi sehingga menghemat waktu dan biaya serta membuat pemilik kost dapat lebih luas mempromosikan rumah kost miliknya.
ANALYTICAL HIERARCHY PROCESS DALAM PEMILIHAN VSAT BUC (BLOCK UP CONVERTER) BERDASARKAN KUALITAS PRODUK
Authors: Normah Normah , Sutomo Dedi , Rifai Bakhtiar
Published: June 2022

ATM disebut sebagai anjungan tunai mandiri oleh karena fungsinya yang praktis dan efisien dalam memberikan berbagai jenis layanan perbankan tanpa harus menempatkan petugas bank ditempat itu. ATM tidak akan mampu bekerja secara optimal tanpa adanya perangkat pendukung, salah satu perangkat pendukung adalah BUC (Block Up Converter) yang terinstal pada sebuah antena. Penelitian ini bertujuan untuk membangun sistem pendukung keputusan yang mampu menganalisa dalam pemilihan VSAT BUC terbaik berdasarkan kualitas produk menggunakan metode Analytical Hierarchy Process dengan Tools Expert Choice. Hasil perhitungan AHP diperoleh prioritas kriteria dalam penilaian terhadap Pemilihan BUC terbaik berdasarkan kualitas. Dimana Power Level, Transmite Gain, Carrier to Noise, Temperatur, dan Intermode menjadi tolak ukur dalam pemilihan BUC. Hasil akhir yang di dapat dari pemilihan BUC oleh tiga alternatif yang berbeda bahwa BUC 5Watt NJRC  memiliki bobot prioritas tertinggi yaitu 33,68%, BUC 5Watt Amplus memiliki bobot prioritas kedua yaitu 33,21% dan BUC 6Watt Anatel memiliki bobot prioritas terakhir yaitu 33,11%.
Hutcheson's Contributions to Action Theory
Authors: Radcliffe Elizabeth S.
Published: June 2022

Jonathan Dancy charges that Hutcheson's distinction between justifying reasons and motivating reasons is unimportant: it is simply between moral reasons and other good reasons. I argue that the distinction is between propositions (which, following Locke, are mental states) with different presuppositions and different functions. One identifies qualities of objects that we desire; the other identifies qualities that we approve. I situate Hutcheson in the current debate about the nature of practical reasons. I argue that he avoids problems posed for factivists (those who say that reasons are facts but have trouble explaining the motivation for actions not based on facts) and for Humeans (those who say that reasons consist in belief-desire pairs but have trouble explaining how these psychological states can justify). On Hutcheson's view, motivating and justifying reasons at times refer to the same qualities, which makes it possible for one to serve the function of the other.
Hutcheson's Theory of Obligation
Authors: Walschots Michael
Published: June 2022

In this article I argue both that Hutcheson has a theory of obligation that is different in important ways from the views of his predecessors and that his theory may not be as problematic as critics have claimed. After briefly sketching a picture of the rich conceptual landscape surrounding the concept of obligation in the Early Modern period, I offer an account of Hutcheson's theory of obligation. Not only does Hutcheson have a view on what previous figures called the source, end, and object of obligation, I illustrate that he focuses on the epistemological question of the origin of the idea of obligation, and he conceives of the necessity involved in obligation in a unique way, namely in terms of the necessity of a perception. I conclude by defending Hutcheson's theory against three objections.
The Natural and the Publick Good: Two Puzzles in Hutcheson's Axiology
Authors: Dorsey Dale
Published: June 2022

Whatever the finer details, Francis Hutcheson is clearly some form of proto-, quasi-, pseudo-utilitarian. But for any utilitarian, the full picture of their moral theory will only emerge once we understand their theory of the good. What, according to said utilitarian, is the nature of happiness? How do we aggregate happiness across persons? In this paper, I discuss two important aspects of Hutcheson's utilitarian axiology each with their own puzzles of interpretation. The first involves Hutcheson's theory of happiness or the ‘natural good’. Hutcheson appears to vacillate between a quantitative hedonism (according to which the value of a pleasure just concerns its intrinsic pleasurableness; its intensity and duration) and a qualitative hedonism (according to which pleasures are not simply judged given their intensity and duration, but also a further qualitative operator). The second concerns Hutcheson's aggregative axiology. Hutcheson appears to offer three inconsistent approaches to understanding the overall good. Bringing these puzzles to light, I think, brings forward a number of challenges in understanding the normative ethics of a key figure in the development of utilitarian moral thought.
RESIDENTS’ PERCEPTIONS OF TOURISM IN RELATION TO THEIR PERSONAL WELL-BEING
Authors: Soldic Frleta Daniela , Durkin Badurina Jelena , Kaliterna Lipovcan Ljiljana
Published: June 2022

This study examines the relationships between residents' perceptions of tourism and their overall personal well-being. In addition, the study aims to find out what differences exist in the perception of personal well-being and the impact of tourism between residents who provide private accommodation for tourists and those who do not.

A questionnaire survey is conducted to collect data from residents of the city of Rijeka, Croatia, and 556 usable questionnaires are generated. The analysis of residents' perceptions is done separately for those who provide private accommodation to tourists and those who do not.

Respondents in both groups reported relatively high levels of personal well-being. However, those who provide private accommodations for tourists are more satisfied with several areas of life. The results show that overall satisfaction with living conditions, perceived negative impacts of tourism, age, and whether or not residents offer accommodation to tourists are significant predictors of their personal well-being.

This study aims to add to the literature on the well-being of residents of tourist destinations by examining the relationship between their perceived well-being and their perceptions of various impacts of tourism in their community.
Log-Linear Model and Multistate Model to Assess the Rate of Fibrosis in Patients With NAFLD
Authors: Attia Iman M.
Published: June 2022

In this paper, the deleterious effects of obesity, type II diabetes, and insulin resistance, systolic and diastolic hypertension on the rate of progression of fibrosis in patients with non-alcoholic fatty liver disease (NAFLD) are illustrated using a new approach utilizing the Poisson regression to model the transition rate matrix. The observed counts in the transition count matrix are used as the response variables and the covariates are the risk factors for fatty liver. Then, the estimated counts from running the Poisson regression are used to estimate the transition rates using the continuous-time Markov chains (CTMCs) followed by exponentiation of the estimated rate matrix to obtain the transition probability matrix at specific time points. A depicted, hypothetical, observational, prospective longitudinal study of 150 participants followed up every year for a total of 29 years recording their demographic characteristics and their timeline follow-up is demonstrated. The findings revealed that insulin resistance expressed by HOMA2-IR had the most deleterious effects among other factors on increasing the rate of fibrosis progression from state 1 to state 2, from state 2 to state 3, and from state 3 to state 4. The higher the level of HOMA2-IR is, the more rapid the rate of progression is. This analysis helps the health policymakers and medical insurance managers to allocate the financial and human resources for investigating and treating high-risk patients with NAFLD. In addition, this analysis can be used by pharmaceutical companies to conduct longitudinal studies to assess the effectiveness of the newly emerging anti-fibrotic drugs.
The Application of the Functional Variable Method for Solving the Loaded Non-linear Evaluation Equations
Authors: Babajanov Bazar , Abdikarimov Fakhriddin
Published: June 2022

In this article, we construct exact traveling wave solutions of the loaded Korteweg-de Vries, the loaded modified Korteweg-de Vries, and the loaded Gardner equation by the functional variable method. The performance of this method is reliable and effective and gives the exact solitary and periodic wave solutions. All solutions to these equations have been examined and 3D graphics of the obtained solutions have been drawn by using the Matlab program. We get some traveling wave solutions, which are expressed by the hyperbolic functions and trigonometric functions. The graphical representations of some obtained solutions are demonstrated to better understand their physical features, including bell-shaped solitary wave solutions, singular soliton solutions, and solitary wave solutions of kink type. Our results reveal that the method is a very effective and straightforward way of formulating the exact traveling wave solutions of non-linear wave equations arising in mathematical physics and engineering.
Progress of Platelet Derivatives for Cartilage Tissue Engineering
Authors: Wu Siyu , Guo Wenlai , Li Rui , Zhang Xi , Qu Wenrui
Published: June 2022

Articular cartilage has limited self-regeneration ability for lacking of blood vessels, nerves, and lymph that makes it a great challenge to repair defects of the tissue and restore motor functions of the injured or aging population. Platelet derivatives, such as platelet-rich plasma, have been proved effective, safe, and economical in musculoskeletal diseases for their autologous origin and rich in growth factors. The combination of platelet derivatives with biomaterials provides both mechanical support and localized sustained release of bioactive molecules in cartilage tissue engineering and low-cost efficient approaches of potential treatment. In this review, we first provide an overview of platelet derivatives and their application in clinical and experimental therapies, and then we further discuss the techniques of the addition of platelet derivatives and their influences on scaffold properties. Advances in cartilage tissue engineering with platelet derivatives as signal factors and structural components are also introduced before prospects and concerns in this research field. In short, platelet derivatives have broad application prospects as an economical and effective enhancement for tissue engineering–based articular cartilage repair.
Early Epigenetic Responses in the Genomic DNA Methylation Fingerprints in Cells in Response to Sublethal Exposure of Silver Nanoparticles
Authors: Chen Yue , Sheng Fei , Wang Xingyu , Zhang Zhihong , Qi Shiyong , Chen Liqun
Published: June 2022

With the rapid development of nanotechnology and nanoscience, nanosafety assessment has raised public concern. Although many studies have illustrated that nanomaterials could lead to genotoxicity, the early alterations of DNA methylation with nanomaterials under low-dose exposure have not been completely clear. In this study, we investigated the potential effect and molecular mechanism of AgNPs on the alternation of DNA methylation fingerprints in HEK293T cells under sublethal exposure. Intriguingly, silver nanoparticle treatment increased 5-mC level and changed methylation-related enzyme contents. Mechanistically, we scrutinized the changes in the molecular signaling and biological functions by means of MeDIP-Seq and RNA-seq. Our results revealed that AgNPs might undermine a number of vital regulatory networks including the metabolic processes, biological regulation and other cellular processes. More specifically at the DNA methylation fingerprints, there were 12 up-regulated and simultaneous hypomethylated genes, and 22 down-regulated and concomitant hypermethylated genes in HEK293T cells responding to AgNPs. Notably, these genes were primarily involved in lipid metabolism and ion metabolism. Together, these responsive genes might be used as early sensitive indicators for the variations of early epigenetic integrity through changing the DNA methylation fingerprints, as reflective of biological risk and toxicity of silver nanoparticles under realistic exposure scenarios.
Design, Synthesis, and Application in OFET of a Quinoxaline-Based D-A Conjugated Polymer
Authors: Dai Zhicheng , Zhang Daohai , Zhang Haichang
Published: June 2022

A novel alternating donor–acceptor polymer PQ1 is designed and synthesized by palladium-catalyzed Stille coupling between quinoxaline as an electron-deficient unit and indacenodithiophene (IDT) as electron-rich groups. Polymer PQ1 presents not only a strong intramolecular charge transfer effect, which is beneficial for the charge transport within single molecules but also a narrow electrochemical band gap and a high highest occupied molecular orbital (HOMO) energy level. In addition, the optical absorption study indicates that the PQ1 film exhibits good aggregation, which is an advantage for the charge transport between neighboring molecules. As a consequence, PQ1 presents p-type semiconductor properties with a high hole mobility of up to 0.12 cm2 V−1 s−1. This study reveals the great potential of quinoxaline-type chromophores in constructing novel organic semiconductors.
Differential Trafficking and Expression of PIR Proteins in Acute and Chronic Plasmodium Infections
Authors: Giorgalli Maria , Cunningham Deirdre A. , Broncel Malgorzata , Sait Aaron , Harrison Thomas E. , Hosking Caroline , Vandomme Audrey , Amis Sarah I. , Antonello Ana , Sullivan Lauren , Uwadiae Faith , Torella Laura , Higgins Matthew K. , Langhorne Jean
Published: June 2022

Plasmodium multigene families are thought to play important roles in the pathogenesis of malaria. Plasmodium interspersed repeat (pir) genes comprise the largest multigene family in many Plasmodium species. However, their expression pattern and localisation remain to be elucidated. Understanding protein subcellular localisation is fundamental to reveal the functional importance and cell-cell interactions of the PIR proteins. Here, we use the rodent malaria parasite, Plasmodium chabaudi chabaudi, as a model to investigate the localisation pattern of this gene family. We found that most PIR proteins are co-expressed in clusters during acute and chronic infection; members of the S7 clade are predominantly expressed during the acute-phase, whereas members of the L1 clade dominate the chronic-phase of infection. Using peptide antisera specific for S7 or L1 PIRS, we show that these PIRs have different localisations within the infected red blood cells. S7 PIRs are exported into the infected red blood cell cytoplasm where they are co-localised with parasite-induced host cell modifications termed Maurer’s clefts, whereas L1 PIRs are localised on or close to the parasitophorous vacuolar membrane. This localisation pattern changes following mosquito transmission and during progression from acute- to chronic-phase of infection. The presence of PIRs in Maurer’s clefts, as seen for Plasmodium falciparum RIFIN and STEVOR proteins, might suggest trafficking of the PIRs on the surface of the infected erythrocytes. However, neither S7 nor L1 PIR proteins detected by the peptide antisera are localised on the surface of infected red blood cells, suggesting that they are unlikely to be targets of surface variant-specific antibodies or to be directly involved in adhesion of infected red blood cells to host cells, as described for Plasmodium falciparum VAR proteins. The differences in subcellular localisation of the two major clades of Plasmodium chabaudi PIRs across the blood cycle, and the apparent lack of expression on the red cell surface strongly suggest that the function(s) of this gene family may differ from those of other multigene families of Plasmodium, such as the var genes of Plasmodium falciparum.
Gardnerella Exposures Alter Bladder Gene Expression and Augment Uropathogenic Escherichia coli Urinary Tract Infection in Mice
Authors: Gilbert Nicole M. , O’Brien Valerie P. , Waller Chevaughn , Batourina Ekatherina , Mendelsohn Cathy Lee , Lewis Amanda L.
Published: June 2022

The anaerobic actinobacterium Gardnerella was first isolated from the bladder by suprapubic aspiration more than 50 years ago. Since then, Gardnerella has been increasingly recognized as a common and often abundant member of the female urinary microbiome (urobiome). Some studies even suggest that the presence of Gardnerella is associated with urological disorders in women. We recently reported that inoculation of Gardnerella into the bladders of mice results in urothelial exfoliation. Here, we performed whole bladder RNA-seq in our mouse model to identify additional host pathways involved in the response to Gardnerella bladder exposure. The transcriptional response to Gardnerella reflected the urothelial turnover that is a consequence of exfoliation while also illustrating the activation of pathways involved in inflammation and immunity. Additional timed exposure experiments in mice provided further evidence of a potentially clinically relevant consequence of bladder exposure to Gardnerella—increased susceptibility to subsequent UTI caused by uropathogenic Escherichia coli. Together, these data provide a broader picture of the bladder’s response to Gardnerella and lay the groundwork for future studies examining the impact of Gardnerella on bladder health.
Microsporidia, a Highly Adaptive Organism and Its Host Expansion to Humans
Authors: Seatamanoch Nirin , Kongdachalert Switt , Sunantaraporn Sakone , Siriyasatien Padet , Brownell Narisa
Published: June 2022

Emerging infectious disease has become the center of attention since the outbreak of COVID-19. For the coronavirus, bats are suspected to be the origin of the pandemic. Consequently, the spotlight has fallen on zoonotic diseases, and the focus now expands to organisms other than viruses. Microsporidia is a single-cell organism that can infect a wide range of hosts such as insects, mammals, and humans. Its pathogenicity differs among species, and host immunological status plays an important role in infectivity and disease severity. Disseminated disease from microsporidiosis can be fatal, especially among patients with a defective immune system. Recently, there were twoTrachipleistophora hominis, a microsporidia species which can survive in insects, case reports in Thailand, one patient had disseminated microsporidiosis. This review gathered data of disseminated microsporidiosis andT. hominisinfections in humans covering the biological and clinical aspects. There was a total of 22 cases of disseminated microsporidiosis reports worldwide. Ten microsporidia species were identified. Maximum likelihood tree results showed some possible correlations with zoonotic transmissions. ForT.hominis, there are currently eight case reports in humans, seven of which had Human Immunodeficiency Virus (HIV) infection. It is observed that risks are higher for the immunocompromised to acquire such infections, however, future studies should look into the entire life cycle, to identify the route of transmission and establish preventive measures, especially among the high-risk groups.
Can Inter-organizational Knowledge-Sharing Improve Enterprise Innovation Performance? The Mediator Effect of Innovation Capability and the Moderator Effect of Network Characteristics
Authors: Dongling Wang , Yuming Zhang , Xinmin Liu , Chen Jiakui , XiaoYi Zhang , Chang He
Published: June 2022

This study investigates the relationship between inter-organizational knowledge-sharing and innovation performance based on the resource-based theory and network embedded theory. It aims to examine the mediating effect of network characteristics in the relationship between inter-organizational knowledge-sharing and innovation performance. Through quantitative study, data is collected from 275 firms and analyzed through regression analysis. The results reveal that inter-organizational knowledge-sharing has a positive effect on enterprise innovation capability. Innovation capability has a positive effect on enterprise innovation performance. The link between inter-organizational knowledge-sharing and innovation performance is mediated by enterprise innovation capability. Evidence in support of full mediation is found. Connection strength and network scale play a positive moderator role in the relationship between inter-organizational knowledge-sharing and innovation capability. The findings provide a theoretical basis for inter-organizational knowledge-sharing and help enterprises establish innovative advantages. These also guide the inter-organizational knowledge-sharing among members in practice.
Characterizing Diagnostic Inertia in Arterial Hypertension With a Gender Perspective in Primary Care
Authors: Pallares-Carratala Vicente , Carratala-Munuera Concepcion , Lopez-Pineda Adriana , Quesada Jose Antonio , Gil-Guillen Vicente , Orozco-Beltran Domingo , Alfonso-Sanchez Jose L. , Navarro-Perez Jorge , Martin-Moreno Jose M.
Published: June 2022

Background and Objectives

Substantial evidence shows that diagnostic inertia leads to failure to achieve screening and diagnosis objectives for arterial hypertension (AHT). In addition, different studies suggest that the results may differ between men and women. This study aimed to evaluate the differences in diagnostic inertia in women and men attending public primary care centers, to identify potential gender biases in the clinical management of AHT.

Study Design/Materials and Methods

Cross-sectional descriptive and analytical estimates were obtained nested on an epidemiological ambispective cohort study of patients aged ≥30 years who attended public primary care centers in a Spanish region in the period 2008–2012, belonging to the ESCARVAL-RISK cohort. We applied a consistent operational definition of diagnostic inertia to a registry- reflected population group of 44,221 patients with diagnosed hypertension or meeting the criteria for diagnosis (51.2% women), with a mean age of 63.4 years (62.4 years in men and 64.4 years in women).

Results

Of the total population, 95.5% had a diagnosis of hypertension registered in their electronic health record. Another 1,968 patients met the inclusion criteria for diagnostic inertia of hypertension, representing 4.5% of the total population (5% of men and 3.9% of women). The factors significantly associated with inertia were younger age, normal body mass index, elevated total cholesterol, coexistence of diabetes and dyslipidemia, and treatment with oral antidiabetic drugs. Lower inertia was associated with age over 50 years, higher body mass index, normal total cholesterol, no diabetes or dyslipidemia, and treatment with lipid-lowering, antiplatelet, and anticoagulant drugs. The only gender difference in the association of factors with diagnostic inertia was found in waist circumference.

Conclusion

In the ESCARVAL-RISK study population presenting registered AHT or meeting the functional diagnostic criteria for AHT, diagnostic inertia appears to be greater in men than in women.
RETRACTED: Multimedia Presentations Through Digital Storytelling for Sustainable Development of EFL Learners’ Argumentative Writing Skills, Self-Directed Learning Skills and Learner Autonomy
Authors: Salem Ashraf Atta Mohamed S.
Published: June 2022

The present study explored the impact of online digital storytelling on developing EAP students’ argumentative writing skills, and its impact on improving self-directed learning skills and learner autonomy in language learning. To reach such ends, a standardized pretest and posttest in argumentative writing skills were designed, which depends on the writing tasks of IELTS task 2 and Independent TOEFL test writing tasks. Also, the self-rating scale of self-directed learning and language Learner Autonomy Scale (LAS) have been exploited. The two experimental groups were trained to write using two different types of learning; group A through online storytelling and group B used offline content producing software to produce digital storytelling to promote writing skills. On the other hand, the control group (group C) used a traditional storytelling strategy. Results primarily revealed that the literacy skills of those who produced their stories with the offline software (group B) improved significantly in comparison to the other experimental group which was taught through online digital storytelling (group A). The control group achieved the least of the three groups in developing target skills. Further, the qualitative analysis of experimental group members’ responses in the semi-structured interviews revealed positive attitudes toward learning through blended learning approaches compared with pure online web-based learning. It is, therefore, recommended that blended learning should be used for students from communities with poor digital literacy and technology infrastructure. Also, online learning should be used with care to cope with community needs to fill a real gap in field practices in language learning to improve multiliteracy skills.
FGF2 Is Protective Towards Cisplatin-Induced KGN Cell Toxicity by Promoting FTO Expression and Autophagy
Authors: Wang Rongli , Wang Lijun , Wang Lihui , Cui Zhiwei , Cheng Feiyan , Wang Wei , Yang Xinyuan
Published: June 2022

It is widely known that chemotherapy-induced apoptosis of granulosa was the main reason for premature ovarian failure (POF). In addition, accumulating evidence has demonstrated that autophagy was involved in it. Studies before have reported that fibroblast growth factor-2 (FGF2) could attenuate cell death via regulating autophagy. In our previous study, FGF2 could decrease granulosa cell apoptosis in cisplatin-induced POF mice. Furthermore, obesity-associated protein [fat mass and obesity-associated protein (FTO)], which decreased significantly in POF mice, could inhibit cell apoptosis via activating autophagy. Moreover, downregulation of FTO could decrease the expression of paracrine factor FGF2. However, the relationship between FTO and FGF2 in granulosa cell autophagy is still unknown. In the present study, Cell Counting Kit-8 (CCK-8) and 5‐ethynyl‐2‐deoxyuridine (EdU) assays showed that exogenous addition of FGF2 could promote cisplatin-induced injured granulosa cell proliferation. Western blotting indicated that FGF2 could inhibit apoptosis of injured granulosa cells via autophagy. Inhibition of autophagy by chemicals suppressed the effect of FGF2 and promoted injured cell apoptosis. In addition, the expression of FTO was decreased in injured cells, and FGF2 addition could reverse it. Overexpression of FTO reduced injured cell apoptosis via activating the autophagy process. Our findings indicated that FGF2 activates autophagy by regulating the expression of FTO, thereby reducing the apoptosis of the injured cells.
Role of Glucagon and Its Receptor in the Pathogenesis of Diabetes
Authors: Jia Yunbo , Liu Yang , Feng Linlin , Sun Siyu , Sun Guangwei
Published: June 2022

Various theories for the hormonal basis of diabetes have been proposed and debated over the past few decades. Insulin insufficiency was previously regarded as the only hormone deficiency directly leading to metabolic disorders associated with diabetes. Although glucagon and its receptor are ignored in this framework, an increasing number of studies have shown that they play essential roles in the development and progression of diabetes. However, the molecular mechanisms underlying the effects of glucagon are still not clear. In this review, recent research on the mechanisms by which glucagon and its receptor contribute to the pathogenesis of diabetes as well as correlations between GCGR mutation rates in populations and the occurrence of diabetes are summarized. Furthermore, we summarize how recent research clearly establishes glucagon as a potential therapeutic target for diabetes.
The Impact of High-Speed Rails on Urban Consumption—From the Perspective of “Local-Adjacent” Effect
Authors: Cai Wendi , Wu Zongfa , Lu Yurong
Published: June 2022

Under the background of the rapid development of high-speed rail (HSR), the urban spatial distance has been significantly compressed. Exploring the impact of high-speed railways on urban consumption from a spatial perspective is conducive to further understanding and clarifying the spatial economic effects caused by the opening of high-speed railways and providing a scientific basis for the future spatial layout of high-speed railways. Based on the panel data of prefecture-level cities from 2008 to 2018, the spatial spillover effect of high-speed railways on urban consumption is explored and decomposed by building a spatial econometric model. The results show that urban consumption shows significant spatial correlation, and the conclusion is still valid under three different forms of spatial weight matrices. In addition, the high-speed railway network has a positive effect on local urban consumption and acts on cities in neighboring areas through a spatial spillover effect. Further analysis shows that the spillover effect has an effective radius of 100–500 km, which is inverted U-shaped with distance, and 300 km from the central city is the optimal radius.
Detecting the Spatial Mismatch of Water Resources and Grain Planting Pattern Changes in China Based on Satellite Data
Authors: Feng Yinan , Wang Jieyong
Published: June 2022

China has achieved sustained growth in grain production and significant changes in grain patterns since the early 21st century. Meanwhile, the contradiction between the shortage of water resources and the development of agriculture is becoming more and more severe. This study introduced Gravity Recovery and Climate Experiment (GRACE) gravity satellite Total Water Storage (TWS) Product to indicate total water storage and calculated the Cumulated Normalized Difference Vegetation Index (CNDVI) of cropland as an indicator for grain growth. Based on the continuous satellite data, this paper revealed the spatial mismatch between water resources supply and grain growth pattern in China. The center of gravity of the CNDVI tends to move northwest, while the GRACE TWS data’s center of gravity is in the opposite direction. There were different relationships between GRACE-TWS and CNDVI changes in different zones. We calculated the pixel-wise spatial Pearson Correlation coefficients of TWS and CNDVI. The TWS data and CNDVI data show negative correlation trends in the water-limited areas such as the northern arid-semiarid region and northern China plain, while they show a positive correlation in relatively sufficient water resources in southeast China. According to the results, the changing pattern of grain production in China is likely to cause the depletion of grain production potential in the water-limited regions, while the southeastern regions with higher potential still have more capacity for agricultural production.