bluuebunny/crossref_metadata_2025 huggingface dataset:
Comparison Study between Artificial Urinary Sphincter and Adjustable Male Sling: A Propensity-Score-Matched Analysis
Authors: Geretto Paolo , Ammirati Enrico , Falcone Marco , Manassero Alberto , Agnello Marco , Della Corte Marcello , Gontero Paolo , Giammò Alessandro
Published: August 2023

Aims: This study aimed to compare the outcomes of the AUS and an adjustable male sling (ATOMSTM). Methods: It was a retrospective observational cohort study with two arms. Propensity score matching (PSM) was performed in order to limit selection bias and, consequently, a comparison between groups in terms of functional outcomes (24 h pad test and perception of improvement questionnaires), complications (overall complications, high-grade complications, reinterventions and explantations) and device survival was performed. Results: 49 patients in both arms were included. The baseline characteristics were similar between the groups. The mean follow up was 43 ± 35 months. Dryness was achieved in 22 patients (44.9%) in the AUS group and 11 (22.5%) in the sling group (p = 0.03). A total of 40 patients declared themselves well improved in the sling group (81%), while 35 (71%) declared the same in the AUS group (p = 0.78). The AUS was associated with more high-grade complications, reinterventions and explantations than the ATOMSTM. Survival at 60 months was 82 ± 9% in the sling group and 67 ± 7% in the AUS group (p = 0.03). Conclusions: While the AUS may be characterized by a higher dry rate, it has an increased risk of high-grade complications and reinterventions. It is proposed that the ATOMS prosthesis can be successfully used for patients who require a less invasive procedure that maintains good functional outcomes.
Does Music Intervention Improve Anxiety in Dementia Patients? A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Authors: Ting Berne , Chen Daniel Tzu-Li , Hsu Wei-Ti , Liang Chih-Sung , Malau Ikbal Andrian , Li Wei-Chih , Lee Sheau-Ling , Jingling Li , Su Kuan-Pin
Published: August 2023

Music interventions (MIs) have been widely used to relieve anxiety in dementia in clinical settings. However, limited meta-analysis with randomized controlled trials (RCTs) on this topic has been conducted so far. A systematic search was conducted in four major databases (PubMed, EMBASE, Web of Science, and Cochrane Library) for data provided by RCTs from the inception to February 2023. The search strategy employed the terms “anxiety AND music AND dementia OR Alzheimer’s disease”. Thirteen RCTs (827 participants) were included. The results showed MI reduced anxiety significantly (SMD = −0.67, p < 0.001), especially for Alzheimer’s disease (p = 0.007) and Mixed (p < 0.001)-type dementia. Moreover, significant improvements in agitation (p = 0.021) and depression (p < 0.001) in dementia were observed. Additionally, several psychological mechanisms which may be associated with MI were reviewed comprehensively. In conclusion, our findings support the efficacy of MI in alleviating anxiety symptoms in dementia patients. PROSPERO Registration (ID: CRD42021276646).
Sarcopenia in Type 2 Diabetes Mellitus: Study of the Modifiable Risk Factors Involved
Authors: Sravya Surapaneni Lakshmi , Swain Jayshree , Sahoo Abhay Kumar , Mangaraj Swayamsidha , Kanwar Jayabhanu , Jadhao Pooja , Das Srijit
Published: August 2023

(1) Background: Sarcopenia has gained much interest in recent years due to an increase in morbidity. Sarcopenia is associated with type 2 diabetes mellitus (T2DM) and vice versa. There is a paucity of information regarding the prevalence and predictors of sarcopenia among T2DM individuals. The aim of the present study was to determine the prevalence and predictors of sarcopenia among T2DM individuals. (2) Methods: This study included 159 diabetics (cases) and 79 non-diabetics (controls) aged >50 years. The subjects were assessed for demographic and anthropometric parameters. Sarcopenia (according to the Asian Working Group for Sarcopenia 2019 criteria) was assessed using Jammer’s hydraulic dynamometer for handgrip strength, dual-energy X-ray absorptiometry for muscle mass, and 6m gait speed. The biochemical investigations included glycated hemoglobin; fasting and prandial glucose; fasting insulin; lipid, renal, liver, and thyroid profiles; serum calcium; phosphorous; vitamin D; and parathyroid hormone (PTH). Appropriate statistical methods were used to determine the significance of each parameter, and a multivariate regression analysis was applied to determine the predictors. (3) Results: The prevalence of sarcopenia was significantly higher among the cases than the controls (22.5% vs. 8.86%, p—0.012). Body mass index (BMI) (OR—0.019, CI—0.001–0.248), physical activity (OR—0.45, CI—0.004–0.475), serum calcium levels (OR—0.155, CI—0.035–0.687), hypertension (OR—8.739, CI—1.913–39.922), and neuropathy (OR—5.57, CI—1.258–24.661) were significantly associated with sarcopenia following multivariate regression analysis. (4) Conclusions: T2DM individuals are prone to sarcopenia, especially those with a low BMI, low physical activity, hypertension, neuropathy, and low serum calcium levels. Hence, by modifying these risk factors among the elderly T2DM, sarcopenia can be prevented.
Evaluation of Intraoral Full-Arch Scan versus Conventional Preliminary Impression
Authors: Jánosi Kinga Mária , Cerghizan Diana , Mártha Krisztina Ildikó , Elekes Éva , Szakács Brigitta , Elekes Zoltán , Kovács Alpár , Szász Andrea , Mureșan Izabella , Hănțoiu Liana Georgiana
Published: August 2023

An accurate impression is vital during prosthodontic rehabilitation. Digital scanning has become an alternative to conventional impressions. This study compares conventional preliminary impression techniques with digital scanning, evaluating the efficiency, treatment comfort, and trueness. Impressions of 28 patients were taken using conventional and digital techniques. The efficiency of both impression techniques was evaluated by measuring the mean working time. A visual analog scale questionnaire (1–10) was used to appreciate the participants’ perceptions of discomfort. Morphometric measurements, which were carried out to determine the differences between the casts, were made on the buccolingual cross sections of teeth 11 and 31 and the distolingual and mesiobuccal cusp tips of each first molar. The total treatment time was 75.5 min for conventional and 12 min for digital impressions. The patients scored a mean discomfort assessment of 6.66 for conventional and 9.03 for digital scanning. No significant differences existed between the examined areas (p < 0.05, Wilcoxon and Mann–Whitney tests) of the digital casts obtained by both techniques. The intraoral scan can be considered as an alternative to conventional preliminary impressions for performing study model analysis during orthodontic treatment planning. The digital impression is more comfortable and accepted by the patients than the conventional impression and has a shorter working time.
Effect of Fabric Areal Weight on the Mechanical Properties of Composite Laminates in Carbon-Fiber-Reinforced Polymers
Authors: Andreozzi Marina , Bianchi Iacopo , Gentili Serena , Mancia Tommaso , Simoncini Michela
Published: August 2023

The present work aims at studying the effect of the reinforcing fabric areal weight on the mechanical properties of composite laminates in carbon-fiber-reinforced polymers. Three different pre-impregnated 2 × 2 twill weaves, characterized by the different areal weight values of 380, 630, and 800 g/m2 were used to produce laminates. These areal weights were selected to represent typical values used in structural application. A hand lay-up technique followed by an autoclave cycle curing was employed to produce the laminates. The desired final thickness of the laminates was obtained by laying-up a different ply number, as a function of the areal weight and thickness of each fabric. Uniaxial tensile and in-plane shear response tests were performed on samples obtained from laminates after curing. Furthermore, the presence of voids in composite materials were detected by performing resin digestion tests. Finally, light optical microscopy and stereomicroscopy analyses allowed observing the different arrangement of the plies in the cross-sections of laminates after curing and evaluating the degree of compaction as a function of the reinforcing fabric used. It was demonstrated that the fabric areal weight significantly affects the mechanical performances of the composite laminates; specifically, the decrease in the areal weight of the twill weave leads to an increase in tensile strength, elastic modulus, and in-plane shear stress, i.e., of about 56.9%, 26.6%, and 55.4%, respectively, if 380 g/m2 and 800 g/m2 fabrics are compared. These results are crucial for an optimal material selection during the design process for industrial applications and help to better understand composite material behavior.
A Comparative Study of HA/DBM Compounds Derived from Bovine and Porcine for Bone Regeneration
Authors: Roldan Lina , Isaza Catalina , Ospina Juan , Montoya Carolina , Domínguez José , Orrego Santiago , Correa Santiago
Published: August 2023

This comparative study investigated the tissue regeneration and inflammatory response induced by xenografts comprised of hydroxyapatite (HA) and demineralized bone matrix (DBM) extracted from porcine (P) and bovine (B) sources. First, extraction of HA and DBM was independently conducted, followed by chemical and morphological characterization. Second, mixtures of HA/DBM were prepared in 50/50 and 60/40 concentrations, and the chemical, morphological, and mechanical properties were evaluated. A rat calvarial defect model was used to evaluate the tissue regeneration and inflammatory responses at 3 and 6 months. The commercial allograft DBM Puros® was used as a clinical reference. Different variables related to tissue regeneration were evaluated, including tissue thickness regeneration (%), amount of regenerated bone area (%), and amount of regenerated collagen area (%). The inflammatory response was evaluated by quantifying the blood vessel area. Overall, tissue regeneration from porcine grafts was superior to bovine. After 3 months of implantation, the tissue thickness regeneration in the 50/50P compound and the commercial DBM was significantly higher (~99%) than in the bovine materials (~23%). The 50/50P and DBM produced higher tissue regeneration than the naturally healed controls. Similar trends were observed for the regenerated bone and collagen areas. The blood vessel area was correlated with tissue regeneration in the first 3 months of evaluation. After 6 months of implantation, HA/DBM compounds showed less regenerated collagen than the DBM-only xenografts. In addition, all animal-derived xenografts improved tissue regeneration compared with the naturally healed defects. No clinical complications associated with any implanted compound were noted.
Sustainable Maritime Transportation Operations with Emission Trading
Authors: Wang Haoqing , Liu Yuan , Li Fei , Wang Shuaian
Published: August 2023

The European Union (EU) has recently approved the inclusion of shipping in its Emissions Trading System, aiming to foster sustainable development within the shipping industry. While this new policy represents a significant step towards reducing carbon emissions, it also poses challenges for shipping companies, particularly in terms of operation costs. To assist shipping companies in devising optimal strategies under the new policy, this study proposes new techniques to determine the optimal solutions for sailing speed and the number of ships on the route, covering both EU and non-EU areas. Additionally, we demonstrate how to adjust these optimal decisions in response to changes in charged fees, fuel prices, and weekly operational costs of ships. This research offers innovative insights into the optimal decision-making process for shipping companies under the new EU policy and serves as a valuable decision-making tool to minimize total costs.
Wave Characteristics over a Dual Porous Submerged Breakwater Using a Fully Nonlinear Numerical Wave Tank with a Porous Domain
Authors: Min Eun-Hong , Koo Weoncheol , Kim Moo-Hyun
Published: August 2023

This study developed a two-dimensional fully nonlinear numerical wave tank (FN-NWT) to examine the nonlinear interaction between waves and dual submerged porous structures. Using the FN-NWT, not only reflection and transmission coefficients, but also wave deformation/force depending on porosity were investigated. The FN-NWT was developed using the boundary element method (BEM), and consisted of a fluid domain and a porous medium domain. Darcy’s law or the non-Darcy (Forchheimer) flow equation were applied to the flow passing through the porous domain. The wave reflection coefficient of the porous submerged structures agreed well with the given experimental data when using Forchheimer flow boundary conditions. Excessive attenuation of the transmitted wave occurred when Darcy’s condition was employed. The difference in each coefficient due to the spacing of the submerged structure was reduced in the porous structure compared with the non-porous structure. The difference according to the incident wave height was clearly revealed in the transmission coefficient. The developed dual-domain FN-NWT can be applied to investigate the nonlinear interaction between waves and porous structures as a first-cut design tool.
An Experimental Investigation into the Feasibility of a DC Hybrid Power Plant for a Northern Sea Route Ship
Authors: Zhou Yi , Pazouki Kayvan , Norman Rose , Gao Haibo , Lin Zhiguo
Published: August 2023

Increasingly, the melting of Arctic ice due to global warming has provided opportunities for commercial shipping between Asia and Europe. Given the vulnerability of the Arctic environment, especially due to emissions of short-lived pollutants from shipping activities, a more effective propulsion system with a comprehensive control strategy is required to reduce fuel consumption, thus potentially mitigating the impacts of shipping activities on the northern sea route (NSR). In this paper, a shipboard DC hybrid system powered by a combination of diesel generator sets and batteries is proposed and analysed in terms of its application on a ship in the NSR. The specific fuel consumption and various losses in the power sources were analysed to develop an efficiency-optimisation control strategy for the proposed DC hybrid power system. To evaluate the performance of the hybrid power system with the proposed optimisation control strategy, lab-scale experiments have been conducted in the Shanghai Marine Diesel Engine Research Institute to compare the proposed system with a conventional hybrid system. The experimental results indicate that the proposed DC hybrid power plant with the energy optimisation control contributes a 5.35% fuel saving compared with the DC fixed-speed diesel electric configuration during a scaled-down NSR scenario.
A Distributed Intelligent Buoy System for Tracking Underwater Vehicles
Authors: Liu Mengzhuo , Zhu Jifeng , Pan Xiaohe , Wang Guolin , Liu Jun , Peng Zheng , Cui Jun-Hong
Published: August 2023

Underwater vehicles play a crucial role in various underwater applications, such as data collection in underwater sensor networks, target detection and tracking, and underwater pipeline monitoring. Real-time acquisition of their states, particularly their location and velocity, is vital for their operation and navigation. Consequently, the development of a remote tracking system to monitor these states is essential. In this paper, we propose a system that can track the underwater vehicle’s location and velocity. We take a systematic approach that encompasses the system architecture, system composition, signal processing, and mobility state estimation. We present the system architecture and define its components, along with their relationships and interfaces. The beacon signal employed in the system features dual-hyperbolic-frequency-modulated (HFM) waveform and an OFDM symbol with cyclic prefix (CP). Based on this beacon signal, we demonstrate how signal processing techniques are utilized to precisely determine the time of arrival and reduce false alarm rates in underwater acoustic channels affected by impulsive noise. Additionally, we explain how the CP-OFDM symbol is used to measure the Doppler scaling factor and transmit essential information for localization and velocity estimation purposes. Utilizing the measurements obtained through signal processing, least squares estimators are used for estimating both the location and velocity. To validate the effectiveness of our approach, we implement the system and conduct field trials. Two separate experiments were conducted in which the diagonal lengths of the square topology were designed to be 1000 m and 800 m. The minimum/maximum root mean square error of localization in the first and second experiment is 2.36/2.91 m and 1.47/2.49 m, respectively. And the minimum/maximum root mean square error of velocity estimation in the first and second experiment is 0.16/0.47 m/s and 0.21/0.76 m/s, respectively. Results confirm the effectiveness of the proposed method in estimating the location and velocity of the underwater vehicle. Overall, this paper provides a practical and effective design of a system to track the location and velocity of underwater vehicles. By leveraging the proposed system, signal processing, and mobility state estimation methods, our work offers a systematic solution. And, the successful field experiment serves as evidence of the feasibility and effectiveness of the proposed system, making it a valuable contribution to the field of tracking underwater vehicles.
Design Considerations on Semi-Submersible Columns, Bracings and Pontoons for Floating Wind
Authors: Ivanov Glib , Hsu I-Jen , Ma Kai-Tung
Published: August 2023

Floating offshore wind turbine (FOWT) is an innovative technology with little industry guidance for its hull design. Various FOWT floaters with different hull shapes claim to support the same turbines. Structural integrity and material expense analyses of different pontoon shapes were conducted, and it was found that some configurations, such as those with every two columns connected by both pontoon and bracing, have advantages over others. However, it is important to note that the choice of pontoon shape should be based on the wave loading conditions the floater will be exposed to. While a T-shaped pontoon provides a cost-effective solution under certain wave loading scenarios, it may not be the best option for all conditions. Specifically, ring pontoon designs with full bracing were found to be necessary for withstanding certain wave loads. Therefore, it is important to consider different Dominant Load Parameters (DLP) and ensure that a FOWT floater can withstand all applicable DLPs. An uneven hexahedral column shape, which combines the best attributes of square and round shapes, is proposed as a better alternative to cylindrical columns. It offers ease of manufacture and reasonably low drag. Bracing is found to be necessary for withstanding the wind turbine’s incurred moment and forces. The conclusion is that platform design should prioritize manufacturing costs and strength over maximizing hydrodynamic performance.
Historical Spatial Radiation Range of the Yongding River Corridor in Beijing Plain Section: Implications for Landscape Patterns and Ecological Restoration
Authors: Yang Ruiying , Liu Zhicheng , Kang Wenxin , Su Junyi , Zhang Renfei , Xu Xiaoming
Published: August 2023

The radiation range of the corridor effect holds great significance for the ecological restoration, planning, and sustainable development of river corridors. This study focuses on the Beijing plain section of the Yongding River, which has been cut off for half a century, and improves the research methodology. Utilizing land use data from 1967 and 1980, ArcGIS and Fragstats were employed to establish 5 km buffer zones on both sides of the Yongding River corridor. The buffer zone analysis method was then applied to investigate landscape pattern changes. Through SPSS correlation analysis and curve fitting, sensitive landscape indices were identified, and their change characteristics were analyzed to unveil the historical spatial radiation range and characteristics of the Yongding River corridor. The findings of this research are as follows: First, as the buffer width increases, the landscape pattern changes, showing a decrease in heterogeneity, an increase in aggregation and spread, and a good connection between dominant patches. Forest land exhibited higher levels of fragmentation and dispersion, cultivated land demonstrated improved dominance, and construction land became more regular and dispersed. Second, the spatial radiation range of the landscape level within the river corridor was approximately 4 km. The inflection point for the radiation range on forest land was found at 3.5–4 km, while for construction land, it occurred at 4.5 km. The outcomes of this study can be utilized to evaluate the impact of river corridors on landscape patterns in the period of good historical ecology. They also provide more targeted measures and scientific basis for landscape pattern protection and river ecological restoration planning after the restoration of water flow in the Yongding River plain.
Comparing the Performance of Machine Learning Algorithms in the Automatic Classification of Psychotherapeutic Interactions in Avatar Therapy
Authors: Hudon Alexandre , Phraxayavong Kingsada , Potvin Stéphane , Dumais Alexandre
Published: August 2023

(1) Background: Avatar Therapy (AT) is currently being studied to help patients suffering from treatment-resistant schizophrenia. Facilitating annotations of immersive verbatims in AT by using classification algorithms could be an interesting avenue to reduce the time and cost of conducting such analysis and adding objective quantitative data in the classification of the different interactions taking place during the therapy. The aim of this study is to compare the performance of machine learning algorithms in the automatic annotation of immersive session verbatims of AT. (2) Methods: Five machine learning algorithms were implemented over a dataset as per the Scikit-Learn library: Support vector classifier, Linear support vector classifier, Multinomial Naïve Bayes, Decision Tree, and Multi-layer perceptron classifier. The dataset consisted of the 27 different types of interactions taking place in AT for the Avatar and the patient for 35 patients who underwent eight immersive sessions as part of their treatment in AT. (3) Results: The Linear SVC performed best over the dataset as compared with the other algorithms with the highest accuracy score, recall score, and F1-Score. The regular SVC performed best for precision. (4) Conclusions: This study presented an objective method for classifying textual interactions based on immersive session verbatims and gave a first comparison of multiple machine learning algorithms on AT.
Novel Roles of Standard Lagrangians in Population Dynamics Modeling and Their Ecological Implications
Authors: Pham Diana T. , Musielak Zdzislaw E.
Published: August 2023

The Lagrangian formalism based on the standard Lagrangians, which are characterized by the presence of the kinetic and potential energy-like terms, is established for selected population dynamics models. A general method that allows for constructing such Lagrangians is developed, and its specific applications are presented and discussed. The obtained results are compared with the previously found Lagrangians, whose forms were different as they did not allow for identifying the energy-like terms. It is shown that the derived standard Lagrangians for the population dynamics models can be used to study the oscillatory behavior of the models and the period of their oscillations, which may have ecological and environmental implications. Moreover, other physical and biological insights that can be gained from the constructed standard Lagrangians are also discussed.
Integrated Analysis of Gene Expression and Protein–Protein Interaction with Tensor Decomposition
Authors: Taguchi Y-H. , Turki Turki
Published: August 2023

Integration of gene expression (GE) and protein–protein interaction (PPI) is not straightforward because the former is provided as a matrix, whereas the latter is provided as a network. In many cases, genes processed with GE analysis are refined further based on a PPI network or vice versa. This is hardly regarded as a true integration of GE and PPI. To address this problem, we proposed a tensor decomposition (TD)-based method that can integrate GE and PPI prior to any analyses where PPI is also formatted as a matrix to which singular value decomposition (SVD) is applied. Integrated analyses with TD improved the coincidence between vectors attributed to samples and class labels over 27 cancer types retrieved from The Cancer Genome Atlas Program (TCGA) toward five class labels. Enrichment using genes selected with this strategy was also improved with the integration using TD. The PPI network associated with the information on the strength of the PPI can improve the performance than PPI that stores only if the interaction exists in individual pairs. In addition, even restricting genes to the intersection of GE and PPI can improve coincidence and enrichment.
Learning of Basic Life Support through the Flipped Classroom in Secondary Schoolchildren: A Quasi-Experimental Study with 12-Month Follow-Up
Authors: Cons-Ferreiro Miguel , Mecias-Calvo Marcos , Romo-Perez Vicente , Navarro-Patón Rubén
Published: August 2023

Background and Objectives: International institutions together with the World Health Organisation recommend the teaching of BLS in schools. Therefore, the objective of this research was to study the feasibility of teaching CPR and AED through the flipped classroom, exploring the medium- and long-term retention of knowledge and practical skills among high school students. Materials and Methods: The sample consisted of 260 secondary schoolchildren (137 in the experimental group (EG) and 123 in the control group (CG)) between 12 and 14 years old (M = 12.75 ± 1.02). Results: The data revealed that the EG obtained better post-course results in the correct position of the hands (p = 0.011), the depth of external cardiac compression (p > 0.001), and the mean time to apply an effective shock with the AED (p = 0.013). The CG obtained better results in compressions with complete chest re-expansion (p = 0.025). These differences disappeared at 6 months (p > 0.05) and 12 months (p > 0.05). Conclusions: A training program based on the flipped classroom is as effective and viable as traditional training, although more efficient since it is applied in less time, in the sequence of action in BLS, CPR skills, and the application of an effective shock with an AED.
A Systematic Review and Meta-Analysis Comparing the Effectiveness of Transversus Abdominis Plane Block and Caudal Block for Relief of Postoperative Pain in Children Who Underwent Lower Abdominal Surgeries
Authors: Xiao Dan , Sun Yiyuan , Gong Fang , Yin Yu , Wang Yue
Published: August 2023

Background and Objectives: Postoperative pain after lower abdominal surgery is typically severe. Traditionally, in pediatric anesthesia, a caudal block (CB) has been used for pain management in these cases. Nowadays, a transversus abdominis plane block (TAPB) seems to be an effective alternative. However, which technique for perioperative analgesia is better and more effective remains unclear in children who undergo abdominal surgeries. The aim of this study was to compare the efficacy and safety of a TAPB and CB for pain management in children after abdominal surgery by conducting a meta-analysis of published papers in this area. Methods: We conducted a thorough search of PubMed, EMBASE, the Cochrane Library, and the Web of Science for randomized controlled trials (RCTs) that compared a TAPB and CB for pain management in children who had abdominal surgery. Two researchers screened and assessed all the information with RevMan5.3 used for this meta-analysis. Pain scores, the total dose of rescue analgesic given, the mean duration of analgesia, the intraoperative and postoperative hemodynamic conditions 24 h after surgery, and adverse events were compared. Results: 15 RCTs that involved a total of 970 pediatric patients were included in this study. The results of this meta-analysis showed that there were no significant differences between the 2 groups in terms of postoperative pain scores at 1 h (SMD = 0.35; 95% CI = −0.54 to 1.24; p = 0.44, I2 = 94%), 6 h (SMD = −0.10; 95% CI = −0.44 to −0.23; p = 0.55, I2 = 69%), 12 h (SMD = −0.02; 95% CI = −0.45 to −0.40; p = 0.93, I2 = 80%), and 24 h (SMD = −0.66; 95% CI = −1.57 to −0.25; p = 0.15, I2 = 94%); additional analgesic requirement (OR 0.25; 95% CI 0.09 to 0.63; p = 0.004, I2 = 72%); total dose of rescue analgesic given in 24 h (SMD = −0.37; 95% CI = −1.33 to −0.58; p = 0.44; I2 = 97%); mean duration of analgesia (SMD = 1.29; 95% CI = 0.01 to 2.57; p = 0.05, I2 = 98%); parents’ satisfaction (SMD = 0.44; 95% CI = −0.12 to 1.0; p = 0.12; I2 = 80%); and intraoperative and postoperative hemodynamic conditions 24 h after the surgery and adverse events (SMD = 0.78; 95% CI = 0.22 to 2.82; p = 0.70; I2 = 62%). Compared to a CB, a TAPB resulted in a small but significant reduction in additional analgesic requirement after surgery (OR 0.25; 95% CI 0.09 to 0.63; p = 0.004). Conclusions: TAPBs and CBs result in similar efficient early analgesia and safety profiles in children undergoing abdominal surgeries. Moreover, no disparities were observed for adverse effects between TAPBs and CBs.
Mid-Thoracic Vertebral Compression Fracture after Mini-Trampoline Exercise: A Case Series of Seven Patients
Authors: Park Sung Cheol , Kim Hyoung-Bok , Chung Hoon-Jae , Yang Jae Hyuk , Kang Min-Seok
Published: August 2023

Background and Objectives: Home-based training exercise gained popularity during the coronavirus disease 2019 pandemic era. Mini-trampoline exercise (MTE) is a home-based exercise that utilizes rebound force generated from the trampoline net and the motion of the joints of the lower extremities. It is known to be beneficial for improving postural balance, stability, muscle strength and coordination, bone strength, and overall health. However, we encountered several patients with mid-thoracic vertebral compression fractures (VCFs) following regular MTE, which was never reported previously, despite having no history of definite trauma. This study aims to report mid-thoracic VCFs after regular MTE and arouse public attention regarding this spinal injury and the necessity of appropriate prior instructions about the correct posture. Patients and Methods: All consecutive patients diagnosed with acute VCFs following regular MTE were included. We collected data on patient demographics, history of MTE, characteristics of symptoms, and radiological findings such as the location of fractures and anterior vertebral body compression percentage. Results: Seven patients (one man and six women) and ten fractures (T5 = 1, T6 = 3, T7 = 2, and T8 = 4) were identified. Symptoms started 2.57 ± 1.13 weeks after the beginning of regular MTE. All patients reported that they were never properly instructed on the correct posture. They also stated that they were exercising with a hunchback posture and insufficient joint motion of the lower extremities while holding the safety bar with both hands, which resulted in increased peak vertical force along the gravity z-axis in the mid-thoracic area and consequent mid-thoracic VCFs. Conclusions: Mid-thoracic VCFs can occur following regular MTE even without high-energy trauma in case of improper posture during exercise. Therefore, public attention on mid-thoracic VCFs following MTE and the appropriate prior instructions are imperative.
Indocyanine Green (ICG) and Colorectal Surgery: A Literature Review on Qualitative and Quantitative Methods of Usage
Authors: Simion Laurentiu , Ionescu Sinziana , Chitoran Elena , Rotaru Vlad , Cirimbei Ciprian , Madge Octavia-Luciana , Nicolescu Alin Codrut , Tanase Bogdan , Dicu-Andreescu Irinel-Gabriel , Dinu Denisa Mihaela , Luca Dan Cristian , Stanculeanu Dana Lucia , Gheorghe Adelina Silvana , Zob Daniela , Marincas Marian
Published: August 2023

Background: Due to its many benefits, indocyanine green (ICG) has gained progressive popularity in operating rooms (ORs) globally. This literature review examines its qualitative and quantitative usage in surgical treatment. Method: Relevant terms were searched in five international databases (1. Pubmed, 2. Sciencedirect, 3. Scopus, 4. Oxfordjournals, 5. Reaxys) for a comprehensive literature review. The main benefits of using ICG in colorectal surgery are: intraoperative fluorescence angiography; fluorescence-guided lymph node involvement detection and the sentinel technique; the fluorescent emphasis of a minute liver tumour, counting just 200 tumour cells; facilitation of fistula diagnosis; and tumour tattooing. This methodology can also be used with quantitative characteristics such as maximum intensity, relative maximum intensity, and in-flow parameters such as time-to-peak, slope, and t1/2max. This article concludes that fluorescence surgery with ICG and near-infrared (NIR) light is a relatively new technology that improves anatomical and functional information, allowing more comprehensive and safer tumour removal and the preservation of important structures.
Aflibercept for Gastrointestinal Bleeding in Hereditary Hemorrhagic Telangiectasia: A Case Report
Authors: Villanueva Bernat , Iriarte Adriana , Torres-Iglesias Raquel , Muñoz Bolaño Miriam , Cerdà Pau , Riera-Mestre Antoni
Published: August 2023

Herein, we present the first described hereditary hemorrhagic telangiectasia (HHT) patient treated with aflibercept for severe GI involvement after tachyphylaxis to bevacizumab, with promising results. HHT is a rare genetic disease characterized by systemic vascular malformations. Gastrointestinal telangiectasia is one of the major involvements that can produce chronic severe iron-deficiency anemia. Nowadays, support treatment with iron replacement therapy, red blood cell transfusions, and antiangiogenic drugs—mainly bevacizumab, a monoclonal antibody against vascular endothelial growth factor (VEGF)—are the main therapeutic options for this complication. The evidence of alternative drugs in patients with failure to this approach, such as tachyphylaxis to bevacizumab, is scarce. Aflibercept is a VEGF inhibitor with antiangiogenic properties approved for the treatment of different types of cancer and ocular neovascularization diseases.
Comparison of the Mg2+-Li+ Separation of Different Nanofiltration Membranes
Authors: Li Tingting , Liu Yueyu , Srinivasakannan Chandrasekar , Jiang Xiaobin , Zhang Ning , Zhou Guoli , Yin Shaohua , Li Shiwei , Zhang Libo
Published: August 2023

Nanofiltration application for the separation of Mg2+-Li+ from salt-lake brines was attempted in the present work. Four different nanofiltration membranes identified in the manuscript as DL, DK, NF-270, and NF-90 were used to treat salt brine with a magnesium to lithium ratio (MLR) of 61, additionally contaminated by the other ions such as Na+, K+, Ca2+, etc. The effect of the dilution factor, operating pressure, circulation rate, and feed pH were assessed to identify the optimal operating conditions for each membrane based on the retention efficiency of each ion. The results showed an insignificant effect of Ca2+ on the retention performance of Mg2+-Li+. Na+ and K+ had a smaller hydration radius and larger diffusion coefficient, which competed with Li+ and altered the separation of Mg2+-Li+. Under the optimal conditions (dilution factor: 40; operating pressure: 1.2 MPa; circulation flow rate: 500 L/h; pH: 7), the retention efficiency of lithium was as low as 5.17%, separation factor (SF) was as low as 0.074, and the MLR in the permeate reduced to 0.088.
Dense Medium Cyclone Separation of Fine Coal: A Discussion on the Separation Lower Limit
Authors: Ni Chao , Xu Guangqian , Chang Jing , Liu Bo
Published: August 2023

The separation of fine coal has been widely discussed in the coal preparation industry due to its high economic potential. Dense medium cyclone (DMC) is the most efficient equipment available for fine coal separation. However, the industrial application of DMC is far from satisfactory due to operational difficulties and maintenance. In this research, particle settling behavior in a dense medium cyclone was analyzed for improved separation. The calculation result about feed pressure and separation lower limit, which fits the experimental data well, might be a guidance for industrial DMC design and operation. According to the calculation result, it is highly recommended that the separation lower limit be set at 0.2 mm rather than 0.1 mm, because the feed pressure head required for the latter (50 D) is three times higher than the former (15 D).
The Açdif Gold-Bearing Shear Zone (Zenaga Inlier, Central Anti-Atlas, Morocco): New Petro-Structural and Geochemical Data
Authors: El Azmi Mohammed , Aissa Mohamed , Moussaid Azizi , Ilmen Said , Mezougane Hafid , Prokopyev Ilya , Loudaoued Ilyasse , Souiri Muhammad , Ouguir Hassane , Aarab Mohammed , Zouhair Mohamed , Maacha Lhou , Admou Safouane
Published: August 2023

The Açdif gold deposit is located in the Zenaga Inlier (central Anti-Atlas), approximately 120 km southwest of the city of Ouarzazate. It hosts gold mineralization associated with a shear zone affecting the metamorphic and magmatic formations of the Eburnean basement. It mainly consists of alternating micaschists, augen gneisses, and orthogneiss. These crystalline rock assemblages are intruded by a variety of granitoids. These are the Azguemerzi granitoids, which are locally affected by Eburnean deformation. Subsequently, these facies are intersected by a swarm of mafic dykes, which show a variety of rocks ranging from microgabbro-dolerite to quartz diorite. Detailed mapping, petro-mineralogical investigations, and geochemistry of the major and trace elements of these magmatic intrusions suggests the following: (i) for the granodiorite rocks (deposited before the basic dykes), a calc-alkaline affinity, with a chemical signature similar to a syn-collisional context; (ii) for mafic dykes, a contemporaneous emplacement of these mafic intrusions with an evolutionary process controlled by fractional crystallization of the same magma of continental tholeiites, whose chemical composition is comparable to that of enriched MORBs (EMORBs). These continental tholeiites are related to a distensive tectonic context that would have affected the Zenaga inlier prior to the Pan-African orogeny.
Amplitude-Resolved Single Particle Spectrophotometry: A Robust Tool for High-Throughput Size Characterization of Plasmonic Nanoparticles
Authors: Calvo Rodrigo , Pini Valerio , Thon Andreas , Saad Asis , Salvador-Matar Antonio , Manso Silván Miguel , Ahumada Óscar
Published: August 2023

Plasmonic nanoparticles have a wide range of applications in science and industry. Despite the numerous synthesis methods reported in the literature over the last decades, achieving precise control over the size and shape of large nanoparticle populations remains a challenge. Since variations in size and shape significantly affect the plasmonic properties of nanoparticles, accurate metrological techniques to characterize their morphological features are essential. Here, we present a novel spectrophotometric method, called Amplitude-Resolved Single Particle Spectrophotometry, that can measure the individual sizes of thousands of particles with nanometric accuracy in just a few minutes. This new method, based on the measurement of the scattering amplitude of each nanoparticle, overcomes some of the limitations observed in previous works and theoretically allows the characterization of nanoparticles of any size with a simple extra calibration step. As proof of concept, we characterized thousands of spherical nanoparticles of different sizes. This new method shows excellent accuracy, with less than a 3% discrepancy in direct comparison with transmission electron microscopy. Although the effectiveness of this method has been demonstrated with spherical nanoparticles, its real strength lies in its adaptability to more complex geometries by using an alternative analytical method to the one described here.
Spectral Behavior of a Conjugated Polymer MDMO-PPV Doped with ZnO Nanoparticles: Thin Films
Authors: Abdelaziz Boutheina Ben , Mustapha Nazir , Bedja Idriss M. , Aldaghri Osamah , Idriss Hajo , Ibrahem Moez , Ibnaouf Khalid H.
Published: August 2023

The purpose of the presented study is to examine the impact of zinc oxide nanoparticles (ZnO NPs) on the spectrum features of poly [2-methoxy-5-(3′,7′-dimethyloctyloxy)-1, 4-phenylenevinylene] (MDMO-PPV). The characteristics of the MDMO-PPV and doped ZnO NPS samples were assessed using several techniques. A set of solutions of MDMO-PPV in toluene that were doped with different ratio percentages of ZnO NPs was prepared to obtain thin films. Pristine and composite solutions were spin-coated on glass substrates. It was observed that MDMO-PPV had two distinct absorbance bands at 310 and 500 nm in its absorption spectrum. The UV-Vis spectrum was dramatically changed when 5% of ZnO NPs were added. The result showed a significant reduction in absorption of the band 500 nm, while 310 nm absorption increased rapidly and became more pronounced. Upon adding (10%) ZnONPs to the sample, no noticeable change was observed in the 500 nm band. However, the 310 nm band shifted towards the blue region. There is a dominant peak in the PL spectrum of MDMO-PPV in its pristine form around 575 nm and a smaller hump around 600 nm of the spectrum. The spectral profile at 600 nm and the intensity of both bands are improved by raising the ZnO NP concentration. These bands feature two vibronic transitions identified as (0-0) and (0-1). When the dopant concentration increased to the maximum dopant percentage (10%), the energy band gap values increased by 0.21 eV compared to the pristine MDMO-PPV. In addition, the refractive index (n) decreased to its lowest value of 2.30 with the presence of concentrations of ZnO NPs.
Vitamin D Deficiency Is Associated with Impaired Sensitivity to Thyroid Hormones in Euthyroid Adults
Authors: Zhou Liyuan , Wang Ying , Su Jingru , An Yu , Liu Jia , Wang Guang
Published: August 2023

The relationship between vitamin D deficiency and sensitivity to thyroid hormones was unclear. We aimed to explore the association of 25-hydroxyvitamin D (25(OH)D) levels with thyroid hormone sensitivity in euthyroid adults. A total of 3143 subjects were included. The serum 25(OH)D, free thyroxine (FT3), free thyrotropin (FT4), thyroid-stimulating hormone (TSH), and other clinical variables were measured. Vitamin D deficiency was defined as 25(OH)D < 20 ng/mL. Thyroid feedback quantile-based index (TFQI), parametric thyroid feedback quantile-based index (PTFQI), thyroid-stimulating hormone index (TSHI), thyrotrophic thyroxine resistance index (TT4RI), and FT3/FT4 were calculated to assess thyroid hormone sensitivity. Results showed that 58.8% of the participants had vitamin D deficiency. They had significantly higher levels of triglyceride, insulin, FT3, FT4, TSH, TFQI, PTFQI, TSHI, and TT4RI and lower levels of high-density lipoprotein cholesterol than those with sufficient vitamin D (all p < 0.05). Logistic regression analysis showed that the risk of impaired sensitivity to thyroid hormones evaluated by TFIQ, PTFQI, TSHI, and TT4RI increased by 68% (OR: 1.68; 95%CI: 1.45–1.95; and p < 0.001), 70% (OR: 1.70; 95%CI: 1.46–1.97; and p < 0.001), 66% (OR: 1.66; 95%CI: 1.43–1.92; and p < 0.001), and 50% (OR: 1.50; 95%CI: 1.30–1.74; and p < 0.001), respectively, in participants with vitamin D deficiency compared with those with sufficient vitamin D after adjusting for multiple confounders. In conclusion, in euthyroid populations, vitamin D deficiency was associated with impaired sensitivity to thyroid hormones.
Epidemiological Surveillance of Hypodermosis in Cattle from Romania
Authors: Dărăbuș Gheorghe , Tomoioagă Vasile Daniel , Florea Tiana , Imre Mirela , Oprescu Ion , Morariu Sorin , Mederle Narcisa , Ilie Marius Stelian
Published: August 2023

Hypodermosis, or warble fly, is an endemic parasitic disease, common in countries from the northern hemisphere. The use of effective insecticides has decreased the frequency of this parasitic disease, with untreated cattle remaining to act as reservoirs. This study focused on assessing the status of hypodermosis in northwestern Romania by means of clinical examination (skin inspection and palpation performed in order to identify nodules) conducted on a number of 11.741 cattle. The study was carried out from March until June 2021. The identified larvae were subject to molecular assays for species identification and genotyping, followed by comparison with data available in the GenBank database. The average prevalence rate of parasitism caused by Hypoderma spp. was 0.31%, with values ranging from a minimum of 0.11% to a maximum of 1.32%. The dominant age group among positive animals was the 1–3 years old category and in terms of breed distribution, most positive cases were seen in cows belonging to an indigenous breed: Bruna de Maramures. April was the most prolific month in terms of nodule count/animal. The species identified in our study by means of molecular assays was H. bovis with two haplotypes: HB3 and HB8.
Genome-Wide Identification and Expression Analysis of the RADIALIS-like Gene Family in Camellia sinensis
Authors: Wang Shaoying , Wen Beibei , Yang Yun , Long Shanshan , Liu Jianjun , Li Meifeng
Published: August 2023

The RADIALIS-like (RL) proteins are v-myb avian myeloblastosis viral oncogene homolog (MYB)-related transcription factors (TFs), and are involved in many biological processes, including metabolism, development, and response to biotic and abiotic stresses. However, the studies on the RL genes of Camellia sinensis are not comprehensive enough. Therefore, we undertook this study and identified eight CsaRLs based on the typical conserved domain SANT Associated domain (SANT) of RL. These genes have low molecular weights and theoretical pI values ranging from 5.67 to 9.76. Gene structure analysis revealed that six CsaRL genes comprise two exons and one intron, while the other two contain a single exon encompassing motifs 1 and 2, and part of motif 3. The phylogenetic analysis divided one hundred and fifty-eight RL proteins into five primary classes, in which CsaRLs clustered in Group V and were homologous with CssRLs of the Shuchazao variety. In addition, we selected different tissue parts to analyze the expression profile of CsaRLs, and the results show that almost all genes displayed variable expression levels across tissues, with CsaRL1a relatively abundant in all tissues. qRT-PCR (real-time fluorescence quantitative PCR) was used to detect the relative expression levels of the CsaRL genes under various abiotic stimuli, and it was found that CsaRL1a expression levels were substantially higher than other genes, with abscisic acid (ABA) causing the highest expression. The self-activation assay with yeast two-hybrid system showed that CsaRL1a has no transcriptional activity. According to protein functional interaction networks, CsaRL1a was well connected with WIN1-like, lysine histidine transporter-1-like, β-amylase 3 chloroplastic-like, carbonic anhydrase-2-like (CA2), and carbonic anhydrase dnaJC76 (DJC76). This study adds to our understanding of the RL family and lays the groundwork for further research into the function and regulatory mechanisms of the CsaRLs gene family in Camellia sinensis.