bluuebunny/crossref_metadata_2025 huggingface dataset:
Assessment of awareness of workers of the forensic medical service of the Republic of Tatarstan (bureau) about tuberculosis infection
Authors: Moskvina E. N. , Abdrakhmanov A. R. , Timerzyanov M. I. , Sharafutdinova A. R.
Published: November 2021

Introduction. Forensic workers are at high risk of contracting Koch's bacillus infection. Significant risk factors for infections are a high microbial load, increased traumatism, and the absence of lifetime medical records of tuberculosis in cadavers admitted for examination. In addition, sporadic cases of infection continue to be reported, necessitating measures to improve the prevention of personnel infection. In view of the above, there is a great need for research into the awareness of bureau personnel, on the basis of which preventive measures will be developed. Purpose of the study — to examine the awareness of bureau personnel about the main issues of tuberculosis infection, its prevention, ways of infection, diagnosis, and clinical manifestations. Materials and methods. The main method of research was an anonymous questionnaire survey of 262 employees of the Kazan bureau of the Republic of Tatarstan. The obtained data were counted on the service onlinetestpad, where the questionnaire was posted. Results. According to the results of the study, 12 employees (4.6%) out of those interviewed in the bureau had tuberculosis. Forty-three employees (16.4%) reported contact with a sick person at their place of work (training). A total of 147 respondents (56.1%) think that it is possible to get infected by a sick person; 39 respondents (14.9%) think that it is possible to get infected while doing professional duties. Some respondents did not consider important aspects in preventing the formation and spread of TB: a significant part of workers (96 workers, 36.6%) wash dirty work clothes at home by themselves and about the same number of respondents (95 workers, 36.3%) do not consider it important to change work clothes when moving from a "dirty" zone to a "clean" one and vice versa. Discussion. Positive results of the questionnaire were associated with a high degree of competence of the staff, dissemination of TB guidelines, training, and supervision by supervisory authorities. Conclusion. Based on the results, it was found that staff at the Bureau of Forensic Medicine are sufficiently informed about methods of specific and non-specific prevention of tuberculosis and have information about the modes of transmission. However, there is a lack of awareness among certain staff members on how to prevent the spread of tuberculosis infection.
Indicators of the quality of life of patients with colorectal cancer: A literary review
Authors: Zhabagin K. T. , Zhabagina A. S. , Rakhmankulova A. M.
Published: November 2021

Relevance: GLOBOCAN estimates 1.9 million new cases of colorectal cancer (CRC) and 935,000 deaths from CRC in 2020.

CRC accounts for every tenth cancer case or dying from cancer. According to the Oncological Service of the Republic of Kazakhstan (RK), in 2019, CRC ranked 5th in incidence and mortality among all cancers. With a survival time of more than five years, one of the main criteria that determine the condition of patients and the effectiveness of treatment is their quality of life (QOL). Understanding QOL parameters is essential to assess the full impact of the disease on an individual, family, and community. The purpose of the study was to analyze the quality-of-life indicators in patients with colorectal cancer and validate a Kazakh variant of the EORTC QLQ-CR-2 questionnaire in RK.

Results: The QOL of patients with CRC globally is relatively low in its physical, mental, social, and clinical aspects. The most important factors affecting the QOL are sexual dysfunction, body dissatisfaction in ostomy patients, chronic recurrent diarrhea, symptoms of distress, and high fatigue. The patient’s lifestyle, age, gender, stage of the disease, and psycho-emotional status all affect the QOL of patients with CRC. It should also be noted that CRC survivors who have been physically active report a better QOL than those who were not physically active.

Conclusion: The fact that no study has been conducted in the RK for the QOL of patients with CRC necessitates a survey to understand the QOL parameters in patients with CRC using the Kazakh version of the EORTC QLQ-CR-2 questionnaire. We plan to conduct such a study in the near future within the framework of grant funding for young scientists IRN AP09058432 KN MES RK and publish the results.
Epidemiological aspects of colorectal cancer in the world and the Republic of Uzbekistan: A literature review
Authors: Tillyashaykhov M. N. , Rakhimov O. A. , Adilkhodjayev A. A. , Djanklich S. M.
Published: November 2021

Relevance: GLOBOCAN 2019 reports that colorectal cancer (CRC) ranks third among mortality causes and fourth among

the newly diagnosed cases in the world. CRC incidence is growing worldwide and in the Republic of Uzbekistan. Thus, in the Republic of Uzbekistan, CRC ranks 5th in the general cancer structure and 2nd in men.

The purpose of the study was to make an epidemiological assessment of global trends in colorectal cancer and CRC incidence in the Republic of Uzbekistan in 2018-2019.

Results: Global CRC incidence and mortality trends show differences depending on territories and level of economic development. Gender differences were also revealed: CRC is more often in men, with the ratio of men to women 1.25: 0.8.

Conclusions: The study of the oncoepidemiological situation on CRC in the Republic of Uzbekistan showed an upward

trend that determines the need for further studies of territorial differences and the search for CRC occurrence factors
AKSELERASI PERMASYARAKATAN TEKNOLOGI PRODUKSI KAKAO MENDUKUNG PENINGKATAN PRODUKTIVITAS KOMODITAS EKSPOR DI SULAWESI BARAT
Authors: Indrayana Ketut , Rahasia Hesti
Published: November 2021

Sulawesi Barat merupakan salah satu daerah penghasil kakao tertinggi diindonesia. Biji kakao merupakan salah satu komoditas ekspor andalan hasil pertanian yang besar dan salah satu komoditas penyumbang tersbesar terhadap Pendapatan Asli Daerah  (PAD) Provinsi Sulawesi Barat.Luas pertanaman kakao di Sulawesi Barat pada tahun 2017 mencapai 145.787 Ha Luas Tanaman Kakao Yang menghasilkan 92.413 Ha, dengan  produksi 73.297 ton, Produktivitas baru mencapai 0,79 ton/ha (Dirjen Perkebunan). Potensi lahan untuk pengembangan kakao di Sulawesi Barat masih sangat terbuka. Potensi pengembagan tersebut didukung oleh potensi lahan yang cukup sesuai untuk kakao seluas 467.627 ha. Hasil kegiatan ini yaitu Pola/model Diseminasi Multi Channel (DMC) dapat meningkatkan adopsi inovasi teknologi budidaya dan pasca panen kakao dari 19,44 persen menjadi 45,56 persen di Kecamatan Kalukku dan dari 30,00 % menjadi 73,89% di Kecamatan Papalang. Peningkatan adopsi inovasi teknologi budidaya dan pasca panen kakao mengakibatkan terjadinya peningkatan produktivitas kakao dari 450,71 kg/ha/th menjadi 720,50 kg/ha/tahun di Kecamatan Kalukku dan dari 570,30 kg/ha/tahun menjadi 1.239,71 kg/ha/ tahun di Kecamatan Papalang setelah dilakukan Kegiatan.Selain itu juga terjadi peningkatan mutu biji kakao yang dihasilkan petani pada ke dua lokasi sehingga sesuai dengan SNI
RESPONS PETERNAK TERHADAP PEMANFAATAN PAKAN DEDAK PADI FERMENTASI UNTUK PERTAMBAHAN BOBOT AYAM KAMPUNG UNGGUL BALITBANGTAN (KUB) FASE GROWER
Authors: Balla P. Tandi , Medi Medi , Aryawiguna Muh. Irfan , Badaruddin Munawir
Published: November 2021

Tujuan dari pelaksanaan penelitian ini adalah untuk mengetahui  pemanfaatan pakan dedak padi fermentasi terhadap  pertambahan bobot badan harian, konversi ransum dan konsumsi ransum ayam Kampung Unggul Balitbangtan (KUB) fase grower. serta mengetahui respons peternak terhadap teknologi tersebut. Penelitian dilaksanakan menggunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 5 ulangan. Hasil penelitian menunjukkan bahwa pemanfaatan dedak padi fermentasi sebanyak 30% dalam ransum dapat meningkatkan pertambahan bobot badan harian, konversi ransum dan konsumsi ransum. Pelaksanaan penyuluhan terkait hasil penelitian cukup efektif dalam meningkatkan pengetahuan, keterampilan dan perubahan sikap responden dengan nilai efektivitas penyuluhan sebesar 35,18%, yang berarti berada pada kriteria cukup efektif.
TINGKAT PARTISIPASI ANGGOTA KELOMPOK TANI DI KELURAHAN MALAKKE KECAMATAN BELAWA KABUPATEN WAJO
Authors: Ellung Ab. , Yusriadi Yusriadi , Erna A. , Harsani Harsani
Published: November 2021

Penelitian yang dilakukan dengan tujuan untuk mengetahui tingkat partisipasi anggota kelompok tani yang ada terhadap kegiatan kelompok tani dan faktor yang mempengaruhi tingkat pasrtisipasi anggota kelompok tani yang dibentuk di kelurahan Malakke, Kecamatan Belawa Kabupaten Wajo.Jenis penelitian ini merupakan penelitian kuantitatif deskriptif yang merupakan jenis penelitian yang dapat menggambarkan suatu fenomena yang terjadi dalam masyarakat suatu wilayah. Alat analisa data digunakan adalah dengan menggunakan Skala Likert dan  regresi linier berganda dengan skala pengukuran yang terbagi atas empat jawaban yaitu Selalu (4), Sering (3), Jarang (2), dan Tidak Pernah (1). Pengukuran variabel tingkat partisipasi anggota kelompok tani digunakan sub variabel partisipasi dalam perencanaan program kelompok tani, pertisipasi dalam pelaksanaan program kelompok tani, partisipasi dalam tahap evaluasi program kelompok tani, komunikasi yang intensif dan kesempatan berpartisipasi. Hasil penelitian  yang dilakukan menunjukkan tingkat partisipasi anggota kelompok tani yang ada di kelurahan Malakke Kecamatan Belawa masih tergolong rendah atau kurang.
PERANAN MEDIA PENYULUHAN ELEKTRONIK TERHADAP TINGKAT ADOPSI INOVASI PETANI PADI SAWAH
Authors: Sirajuddin Arief , Rukka Hermaya , Tandi Ismai , Muzakkir Muzakkir
Published: November 2021

Tujuan menggunakan media adalah untuk memperjelas informasi yang disampaikan sehingga dapat merangsang pikiran, perasaan perhatian dan kemampuan sasaran. Dengan demikian media berperan penting antara lain dalam memberikan pengalaman yang kongkrit dan sesuai dengan tujuan belajar. misalnya tingkat pendidikan formal petani yang sangat bervariasi, keterbatasan sarana dan waktu belajar bagi petani. Penelitian yang dilaksanakan termasuk jenis penelitian deskriptif dengan metode survei yaitu suatu metode dalam meneliti status kelompok manusia, suatu obyek, suatu set kondisi, suatu system pemikiran ataupun suatu kelas peristiwa pada masa sekarang. Tujuan penelitian ini adalah untuk membuat deskripsi, gambaran atau lukisan secara sistematis, faktual dan akurat mengenai nfakta-fakta, sifat-sifat serta hubungan antar fenomena yang diselidiki. Populasi penelitian ini adalah anggota Gapoktan Salewatang  yang berjumlah 380 orang di Desa Kalukuang Kecamatan Galesong Kabupaten Takalar. Tata cara pengambilan sampel dilakukan sebagai berikut : Penentuan sampe (responden) dilakukan secara sample acak dengan mengambil  2 kelompok yaitu kelompok Berantas beranggotakan 25 orang dan kelompok Ingin Maju yang berjumlah 25 orang sehingga jumlah sampel secara keseluruhan berjumlah 50 orang. Peranan media elektronik terhadap tingkat adopsi inovasi petani padi sawah sangat berperan dimana media Pemutaran film terdapat 50 % responden pada kategori tinggi, media internet (media sosial)  50 % pada kategori sedang, media televisi 54 % pada kategori tinggi sedangkan media power point 56 % berada pada kategori sedang.  Media elektronik yang paling efektif digunakan dalam kegiatan penyuluhan menurut responden adalah semua media elektronik sangat  merespons tingkat adopsi inovasi, namun tingkat keefektifan tergantung dari tujuan penyuluhan yang akan dicapai dimana rata2 tingkat keefektifan 32,5 % tidak efektif, 44 % cukup efektif   dan 23,5 % Efektif. Hubungan karakteristik petani terhadap tingkat adopsi inovasi petani padi sawah dengan menggunakan media Elektronik adalah pemutaran film dengan nilai korelasi 0,191 *, Media Internet 0,183*, media televisi 0,062 tidak berthubungan nyata dan power point nilai korelasi 0,058 artinya tidak juga berkorelasi nyata dengan tingkat adopsi inovasi dalam penerapan jajar Legowo.
KAJIAN USAHA PENGGEMUKAN SAPI BALI DI KABUPATEN MAROS DAN BARRU, PROVINSI SULAWESI SELATAN
Authors: Tondok A.R. , Qomariyah N. , Sariubang M.
Published: November 2021

Permasalahan yang dihadapi penggemukan sapi di Kabupaten Maros dan Barru antara lain rendahnya pengetahuan penyusunan pakan murah yg berkualitas dan kelembagaan ekonomi petani yang belum berkembang. Tujuan penelitian untuk mengetahui kelayakan usahatani penggemukan sapi dengan memanfaatkan pakan lokal di Kabupaten Maros dan Kabupaten Barru. Metode dasar yang digunakan dalam penelitian ini adalah metode deskriptif, penentuan sampel secara purposive dan analisis data dengan analisis parsial usahatani selama satu kali proses produksi (3 bulan) menggunakan pendekatan dengan rumus perhitungan: Pd = TR – TC, dilanjutkan dengan R/C ratio. Hasil pengkajian menunjukkan bahwa teknologi penggemukan sapi dengan pemberian pakan konsentrat menghasilkan pertambahan bobot badan (PBB) rata-rata sebesar 0,6-07 kg/ekor/hr. Dalam tiga bulan penggemukan sapi Bali memberikan pendapatan bersih sebesar Rp. 1.069.854,-/ekor - Rp. 7.521.500,- per ekor dengan R/C sebesar 1,20-1,98 yang berindikasi bahwa usaha tersebut menguntungkan dan layak untuk diusahakan.
KAJIAN TEKNOLOGI BUDIDAYA JAGUNG SPESIFIK LOKASI PADA LAHAN SUBOPTIMAL DI KABUPATEN TAKALAR
Authors: Amir Amir , Wahid Wahid
Published: November 2021

Sulawesi Selatan memiliki lahan kering beriklim kering seluas  1.238.520 Ha sebagai potensi pengembangan jagung. Produktivitas tanaman pangan di lahan kering beriklim kering dapat ditingkatkan bila dikelola secara berkelanjutan dan memanfaatkan teknologi hasil-hasil penelitian. Pengkajian bertujuan melihat pengaruh paket teknologi budidaya jagung spesifik lokasi terhadap pertumbuhan dan produksi pipilan kering jagung. Kegiatan disusun menurut rancangan acak kelompolk (RAK), empat ulangan dan lima paket teknologi sebagai perlakuan. Kegiatan dilaksanakan dengan tidak mengolah tanah (TOT). Parameter pengamatan dilakukan terhadap komponen pertumbuhan dan komponen hasil tanaman jagung. Paket teknologi A memberikan produksi pipilan kering jagung tertinggi (10,5 t/ha) dan paket teknologi E (Kontrol) memberikan produksi pipilan kering lebih rendah (7,4 t/ha) dari paket teknologi lain. Paket teknologi A memberikan jumlah butir per kilogram biji paling sedikit (3.212 butir).
APLIKASI PLANT GROWTH PROMOTING RHIZOBACTERIA (PGPR) AKAR TUMBUHAN PUTRI MALU TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN KACANG PANJANG (Vigna sinensis L.)
Authors: Arinong Abd. Rahman , Nispasari Nispasari , Wahab Arman , Nurcholis Jati
Published: November 2021

Aplikasi Plant Growth Promoting Rhizobacteria(PGPR) Akar Tumbuhan Putri Malu Terhadap Pertumbuhan dan Produksi Tanaman Kacang Panjang (Vigna sinensis L.). Penelitian ini bertujuan untuk mengetahui pengaruh aplikasi PGPR akar tumbuhan putri malu terhadap pertumbuhan dan produksi tanaman kacang panjang, dan untuk meningkatkan pengetahuan, sikap dan keterampilan petani terhadap aplikasi PGPR akar tumbuhan putri malu terhadap pertumbuhan dan produksi tanaman kacang panjang. Kajian ini dilaksanakan di Desa Batara, Kecamatan Labakkang, Waktu pelaksanaan pada bulan Maret sampai bulan Mei 2020. Metode kajian dilaksanakan dengan menggunakan Uji F yang terdiri dari 4 perlakuan dan 3 ulangan, sehingga dihasilkan 12 petak percobaan. Perlakuan P0(tanpa pemberian PGPR), P1(8 ml/tanaman + 1 L air/plot), P2(8,5 ml/tanaman + 1 L air/tanaman), P3(9 ml/tanaman + 1 L air/plot). Hasil menunjukkan bahwa P1 (PGPR dosis 9 ml/tanaman + 1 L air/plot) memberikan hasil terbaik dengan rata-rata tinggi tanaman yaitu (183,38), jumlah daun (60 helai, dan berat basah (229,78 gr) diantara perlakuan lainnya.
RESPONS PERTUMBUHAN TANAMAN TERUNG UNGU (Solanum melongena L.) DENGAN PERBEDAAN JARAK TANAM DAN PEMBERIAN POC DAUN GAMAL
Authors: Prasetya Bagus , Husain Husain , Parawansa Ismaya N.R , Aimanah Ummu
Published: November 2021

Pupuk organik dapat berbentuk padat maupun cair. Kelebihan pupuk organik cair (POC) adalah unsur hara yang dikandungnya lebih cepat tersedia dan mudah diserap akar tanaman. Kajian ini bertujuan untuk mengetahui respons pertumbuhan tanaman terung ungu (Solanum molongena L.) terhadap jarak tanam dan Pemberian POC daun gamal.  Kajian dilaksanakan di Kelompoktani Ajulukana, Desa Sokkolia, Kecamatan Bontomarannu, Kabupaten Gowa pada Bulan Maret sampai Mei 2017. Kajian dilaksanakan dalam bentuk demonstrasi plot yang terdiri dari 4 perlakuan yaitu K1 (jarak tanam 60 cm x 70 cm diberi POC daun gamal 180 mL/plot), K2 (jarak tanam 100 cm x 150 cm tanpa POC daun gamal), K3 (jarak tanam 100 cm x 150 cm diberi POC daun gamal 180 mL/plot) dan K4 (jarak tanam 60 cm x 70 cm tanpa POC daun gamal). Hasil penelitian menunjukkan bahwa perlakuan K4 memberikan tinggi tanaman yang tertinggi mulai dari 1 sampai 4 MST, dan berbeda nyata dengan perlakuan lainnya pada 1 dan 2 MST. Sedangkan pada pengamatan jumlah daun, K4 menghasilkan jumlah daun terbanyak pada 1 MST, tetapi pada 2 – 4 MST K3 memberikan jumlah daun terbanyak walaupun berbeda tidak nyata dengan K3
OPTIMALISASI TEKNIK ISOLASI DAN PURIFIKASI DNA MENGGUNAKAN BUFFER CTAB (CETYLTRIMETHYL AMMONIUM BROMIDE) PADA TANAMAN MARKISA (Passiflora sp.) DATARAN RENDAH KABUPATEN JENEPONTO
Authors: Farhanah A. , Ashar Jabal R. , Hamzah P.
Published: November 2021

Penelitian ini bertujuan untuk mendapatkan prosedur metode CTAB dan metode purifikasi DNA yang tepat untuk menghasilkan kuantitas dan kualitas DNA yang baik yang berasal dari tanaman  markisa dataran rendah. Penelitian ini dilaksanakan di dua tempat, yaitu kabupaten Jeneponto untuk pengambilan sampel tanaman markisa dan untuk pengisolasian dan pengujian DNA dilakukan di Laboratorium Biosains dan Sumber Daya Hayati Tanaman Program Studi Agroteknologi Jurusan Budidaya Pertanian Fakultas Pertanian Universitas Hasanuddin Makassar. Penelitian ini berlangsung dari bulan September 2013 hingga Desember 2013. Penelitian dilaksanakan dalam enam metode isolasi DNA dengan menggunakan larutan CTAB, pengujian kualitas serta kuantitas DNA, pemurnian (purifikasi) DNA pada hasil isolasi terbaik, dan pengujian kualitas serta kuantitas pada hasil pemurnian. Berdasarkan uji kualitas dan kuantitas, berat sampel sebesar  0,200 g, suhu inkubasi hasil ekstraksi pada suhu 65oC selama 30 menit, dan  kecepatan sentrifugasi sebesar 12.000 rpm selama 10 menit dapat menghasilkan DNA yang memiliki kemurnian yang cukup baik dan tampak pita DNA yang cukup tebal berkisar  1500 – 5000 kb setelah hasil isolasi DNA dielektroforesis. Sedangkan pemurnian kembali menggunakan kloroform : isoamylalkohol, isopropanol, dan ethanol 70% menunjukkan kualitas dan kuantitas DNA yang baik.
PENERAPAN TEKNOLOGI PESTISIDA NABATI DAUN PEPAYA UNTUK PENGENDALIAN HAMA TERUNG
Authors: Vandalisna Vandalisna , Mulyono Sugeng , Putra Budi
Published: November 2021

Penelitian bertujuan untuk mengetahui tingkat adopsi petani tentang penggunaan pestisida nabati daun pepaya untuk pengendalian hama pada tanaman terung dan menganalisis perubahan pengetahuan, sikap, dan keterampilan petani dalam membuat dan mengaplikasikan pestisida nabati daun pepaya sebagai pestisida alternatif terhadap pengendalian hama tanaman terung. Penelitian dilaksanakan di Kelompok Wanita Tani Bunga Tulip Kelurahan Bontoramba Kecamatan Somba Opu Kabupaten Gowa Provinsi Sulawesi Selatan. Berlangsung dari Bulan Februari sampai Juni 2019. Metode yang digunakan adalah demonstrasi plot dan metode survei. Metode demonstrasi plot dengan menggunakan dua perlakuan yaitu perlakuan 0,25 ml pestisida anorganik/liter air, yang digunakan = 800 ml (P1)  dan 20 ml pestisida nabati daun pepaya/liter air, yang digunakan = 800 ml (P2). Aplikasi pestisida nabati  daun papaya pada tanaman terung dapat mengendalikan hama tanaman terung secara efektif dengan dosis 20 ml/liter air, menekan intensitas serangan hama tanaman terung hasil perlakuan terbaik yaitu pestisida nabati daun pepaya (P2) dengan hasil berbeda nyata 0,76 % sedangkan pestisida anorganik (P1) 1,71%. Hal demikian karena pestisida nabati daun pepaya memiliki bahan aktif papain baik secara langsung maupun secara sistemik dapat mengurangi aktivitas hama dan bahkan hama akan mati. Sebelum dan sesudah penyuluhan dilaksanakan evaluasi untuk mengetahui sejauhmana tingkat adopsi terhadap pengetahuan, sikap dan keterampilan petani tentang penerapan teknologi pestisida nabati daun pepaya untuk pengendalian hama terung. Hasil evaluasi penyuluhan menunjukan respons petani terhadap pestisida nabati daun pepaya pada tanaman terung menunjukan peningkatkan pengetahuan 32,8%, sikap 33,7% dan keterampilan 33,5%.  Pelaksanaan penyuluhan dinyatakan 69,7% berada pada kategori Efektif.
Synthesis of 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives as new anticancer agents
Authors: Pangal Anees , Mujahid Yusufi , Desai Bajarang , Shaikh Javed A. , Ahmed Khursheed
Published: November 2021

Under solvent free conditions and in presence of a base 3-(2-(subsituted-(trifluoromethyl)phenylamino)acetyl)-2H-chromen-2-one derivatives were synthesized by grinding technique. Structural investigations were carried out with IR studies, HRMS, 1HNMR and 13CNMR. The compounds were checked for their in vitro anticancer activities against three different human cancer cell lines viz human breast cancer cell line (MCF-7), human cervical cancer cell line (HeLa) and human oral squamous cell carcinoma (SCC-40) using SRB method. All the title compounds showed low toxicity towards non-malignant PBMC cells indicating their tumour selectivity. The compounds exhibited good in vitro anti-proliferative potency at lower concentrations against HeLa and MCF-7 cell lines and remain moderately active against SCC-40.
Synthesis, anti-tubercular evaluation and molecular docking studies of Nitrogen-rich piperazine-pyrimidine-pyrazole Hybrid Motifs
Authors: Vavaiya Bhavinkumar , Patel Shivani , Pansuriya Vrajlal , Marvaniya Vanita , Patel Popatbhai
Published: November 2021

A convenient and efficient synthesis of a series of ethyl-1-(6-(4-substitutedacetylatedpiperazin-1-yl)pyrimidin-4-yl)-5-amino-1H-pyrazole-4-carboxylate (8a-8j) has been developed by five steps which include activation of a methylene group, hydrazinolysis, cyclisation and chloro-amine coupling reactions. Moreover, our proposed mechanism was confirmed in this study demonstrating that ethyl 5-amino-1-(6-chloropyrimidin-4-yl)-1H-pyrazole-4-carboxylate is the key intermediate to fulfill the desired outcomes. In silico and in vitro studies were carried out to identify the active agents among the developed adducts against mycobacterium tuberculosis (PDB ID:4TRO). Compound 8a (Docking Score: -26.81 and MIC: 1.6 ug/mL) was found to be the most potent among the synthesized molecules. All the synthesized compounds showed acceptable drug-like properties which make them suitable for further lead modification using in silico design approaches.
Synthesis and biological evaluation of some new 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines as antimicrobial agents
Authors: Myrko Iryna , Chaban Taras , Matiychuk Vasyl
Published: November 2021

A series of some new pyrazole-substituted 7H-[1,2,4]triazolo[3,4-b][1,3,4]thiadiazines was synthesized in this study. The structures of target substances were confirmed by using 1H and 13С NMR spectroscopy, mass spectrometry and elemental analysis. The synthesized compounds have been evaluated for antimicrobial activity against five bacterial strains (Escherichia coli, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Staphylococcus aureus) and two fungal strains (Candida albicans and Cryptococcus neoformans). The antimicrobial screening studies of synthesized substances established that 2 of 12 compounds show pronounced antibacterial activity against the strain Staphylococcus aureus.
Investigating the occupant existence to reduce energy consumption by using a hybrid artificial neural network with metaheuristic algorithms
Authors: Elshaboury Nehal
Published: November 2021

There is an acute need to evaluate the energy consumption of buildings in response to climate change. The “occupant” factor has been largely overlooked in building energy analysis. This research aims at investigating occupancy existence in the office environment using a hybrid artificial neural network with metaheuristic algorithms for improved energy management. It proposes and compares three classification models, namely particle swarm optimization (PSO), gravitational search algorithm (GSA), and hybrid PSO-GSA in combination with the feedforward neural network (FFNN). The inputs to these models are data related to temperature, humidity, light, and carbon dioxide emissions. Two data sets are used for testing the models while the office door is open and closed. The capabilities of the optimized models are evaluated using best, average, median, and standard deviation of the mean squared error. Most of the performance metrics indicate that the FFNN-PSO-GSA model exhibits better performance compared to the other models using the two datasets. The proposed model yields a classification accuracy ranging between 98.47-98.73% using one predictor (i.e., temperature). Besides, it yields an accuracy ranging between 85.45-94.03% using temperature and CO2 predictors. It can be concluded that the FFNN combined with PSO and GSA algorithms can be a useful tool for occupancy detection modeling.
Production and evaluation of sorghum-based complementary foods supplemented with African Yam bean and Crayfish flours
Authors:   Department of Food Science and Technology, Enugu State University of Science and Technology, P.M.B 01660, Enugu, Nigeria, Eseroghene Egbujie Augustine , Ikechukwu Okoye Joseph ,   Department of Food Science and Technology, Enugu State University of Science and Technology, P.M.B 01660, Enugu, Nigeria
Published: November 2021

This study was carried out to evaluate the proximate, mineral and sensory properties of nutritive and ready-to-eat complementary foods formulated from blends of sorghum, African yam bean and crayfish flour. The protein, ash, fat and crude fibre contents of the samples increased significantly (p<0.05) with increase in substitution with African yam bean and crayfish flours from 13.56 ± 0.29 –23.88 ± 0.82%, 2.77 ± 0.02 – 3.67 ± 0.02%, 1.85 ± 0.01-3.64 ± 0.01 and 1.46 ± 0.06 – 2.15 ± 0.02%,respectively, while the carbohydrate and energy contents decreased. The control sample without substitution with African yam bean and crayfish flours (100% malted sorghum flour) had the highest carbohydrate (72.36 + 0.21%) and energy (364.33 ± 0.35KJ/100g) contents. The mineral content of the complementary foods also showed similar increases in calcium (12.68 ± 1.24 – 84.86 ± 7.83mg/100g), iron (2.68 ± 0.03 – 7.99 ± 0.08mg /100mg) and zinc (1.28 ± 0.02 – 1.63 ± 0.13mg/100g) with increase in substitution with African yam bean and crayfish flours, while the phosphorous and potassium contents decreased. The control sample without substitution had the highest phosphorus (257.01 + 41.44mg/100g) and potassium (346.20 + 0.03mg/100g) contents, respectively. The sensory properties of the samples showed that the colour, taste, mouth feel and texture of the control sample were significantly (p<0.05) the most acceptable to the assessors compared to the samples substituted with African yam bean and crayfish flours at different graded levels. Although, the control sample had better consumer’s sensory attributes, it was significantly (p<0.05) lower in nutrient contents compared to the formulated samples with the exception of carbohydrate, phosphorus and potassium. The study, therefore, showed that the macro and micronutrient contents of the gruels can be improved by substituting sorghum-based traditional complementary food with African yam bean and crayfish flours at the levels of 5 to 30% and 5 to 20%, respectively in the preparation of complementary foods.
The Practicability of Language in Business Context: A Reviewed Study
Authors: Alhumsi Husam
Published: November 2021

The world witnesses a noticeable rapid growth in information technology development of society pertaining to the language of business. One of the remarkable linguistic tools in business communication lies in the form blogs of effective companies. Therefore, the purpose of this paper is to show how effective business context are conducted by the assistance of discourse linguistics related to business. It is obvious that there is a need to concentrate on the cultural meaning relating to the websites’ form and content in the e-commerce context. Research also showed that there is lack of research pertaining to language role and its impact on limitation of websites and blogs. In reviewing literature, according to Forrester Research, most Chinese on-line consumers are convenient with websites involving content in language own use. Further studies and recommendations are presented accordingly.
An Analysis of Acceleration and Speed Performances Through the Positions in Handball
Authors: Taşkın Cengiz , Taşkın Ali Kemal
Published: November 2021

This research was conducted in order to compare the acceleration and speed performances of handball players according to their positions. A total of 60 male handball players that includes 5 goalkeepers, 15 middle playmakers, 7 right playmakers, 8 left playmakers, 7 right wingers, 8 left wingers and 10 pivots who actively play handball in the 2nd league of the Turkish handball federation has participated in the study voluntarily. Average age of the subjects participating in the study is determined as 19.5±1.43 for the goalkeepers, 19.3±1.35 for the right-left playmakers, 18.7±1.29 for the right-left wingers, 19.1±1.89 for the pivot players. Acceleration and speed performances of the subjects were measured in accordance with the measurement technique and all the data obtained were analyzed in the SPSS 20.0 software package program. Results that is obtained is examined, it is seen that the best values in terms of acceleration and speed performance were the performance values of right-left playmakers and right-left wing players, while the worst performance values belonged to pivot players. As a result of our study, it was observed that athletes have different physical performances in handball according to their playing positions.
The Effects of Swimming Training Program on Serum Minerals and Oxidative Stress in Men Aged 20-25 Years
Authors: Adıgüzel Serdar , Doğru Yeliz
Published: November 2021

In this study, the effects of 8-week swimming training applied to men aged 20-25 on sodium, potassium, magnesium, calcium, unsaturated iron binding capacity (UIBC), iron, CRP, creatinine, bilirubin, albumin parameters were investigated. Ten men with a mean age of 23.07±1.76 years participated in the study. A swimming training program was applied to the participants for 10 weeks/3 days. All tests and measurements were performed before starting the 8-week training program and after completing the 8-week program. The data obtained from the study were analyzed using the SPSS 15.0 package program. The normality distribution of the data was made using the shapiro-wilk test. Participants’ pre-post test measurements were analyzed with the Wilcoxon signed-rank test. According to the results of the data, there was a statistically significant difference between pre-post test data for body weight (BW), sodium, magnesium, creatinine, albumin and bilirubin (p < 0.05). As a result, it can be said that the changes in the minerals and some biochemical parameters necessary for the body with the training programs applied regularly can affect the performance.
Remembering the commons and reinvigorating them
Authors: Ray Krishnendu
Published: November 2021

The Routledge Handbook of Food as a Commons proposes a normative view of what food ought to be, in the process highlighting instances where and when that potential has been actualized. Food currently is an object to sell and extract private value rather than social sustenance. This book proposes that food be reconceptualized against its long liberal and recent neoliberal history as property, making a persistent argument about decommodifying food in 24 detailed chapters. It is in re-commoning that the more than two dozen authors of the book--many of them leaders in their field--find better, alternative ideas about the right to food, global public good, food justice, and food sovereignty. They highlight how food as a commodity is currently characterized by its tradable features (appearance, calorie, price, packaging, purchasing power, taste, etc.), thereby denying its non-economic values. It asks two central questions: what would good policies look like if we build on the assumption that food should be the commons, and how do we get there?
Il vissuto di bambini e adolescenti con artrite idiopatica giovanile
Authors: Mambelli Lorenzoiara , Menghi Agnese , Lama Camilla , Marchetti Federico
Published: November 2021

Chronically ill children show an increased risk of developing a psychological-psychiatric disorder, with an important impact on their quality of life. The paper describes all the cases of Juvenile Idiopathic Arthritis (JIA) in the Paediatric Rheumatology Unit in Ravenna with documented psychological-behavioural problems. 23% of juvenile idiopathic arthritis patients have psychological-behavioural problems and 9% have requested cognitivebehavioural therapy, with good results. One of the most significant aspects is the treatment with methotrexate (MTX), which is an important drug in the management of JIA cases and, as it is known, is burdened with side effects such as malaise and vomiting, even before its intake. Half of the patients on MTX therapy show this "intolerance", which sometimes also leads to the voluntary withdrawal of the drug. Therefore, an anticipatory approach to these issues and an adequate and timely psychological care are increasingly necessary.
Chetoacidosi diabetica e urine scure: quale diagnosi?
Authors: Tagliani Sara , Avventi Chiara , Ventresca Silvia , Dal Bo Sara , Graziani Vanna , Marchetti Federico
Published: November 2021

During the onset of diabetic ketoacidosis (DKA), the appearance of hyperchromic urines is a rare occurrence even if already described in the literature. The patient with DKA presents an increased risk to suffer of macrohaematuria due to nephrolithiasis (associated or not with urinary tract infections) and renal vein thrombosis. False macrohaematuria in rhabdomyolysis with myoglobinuria can also occur. This paper describes a case of an 11-year-old boy with severe onset of DKA, with macrohaematuria from kidney stones. The causes of nephrolithiasis in children with DKA are also reported.
Sindrome di Morquio e sferocitosi ereditaria
Authors: Gramaglia Simone Maria Calogero , Lo Presti Mariaserena , Casà Carmelina , Gramaglia Giuseppe
Published: November 2021

Metabolic diseases are rare genetic conditions in the paediatric age. The diagnostic process is often complex and the diagnosis comes even years after the onset of symptoms. The article presents the only documented case of Morquio syndrome and hereditary spherocytosis managed in a second-level Centre using enzyme replacement therapy.
La calidad de las bases de datos para el uso de geotecnologías en salud
Authors: Beceyro Ana Carolina
Published: November 2021

El análisis de las bases de datos de intoxicaciones por plaguicidas en la provincia de Mendoza, Argentina, y la revisión de otras sobre enfermedades de notificación obligatoria, reveló el importante subregistro existente en la primera debido a problemas de carga y codificación de los datos. Esta situación genera dificultades para el análisis de la dinámica espacial del problema de salud a través del uso de geotecnologías, así como para sistematizar los datos y comprender la problemática. Por lo expuesto, se analizó la información disponible, para la provincia, en las bases de datos correspondientes a ocho eventos de notificación obligatoria categorizados como “intoxicaciones” - entre 1993 y 2018-. Esto permitió establecer el nivel de subregistro y detectar problemas en la carga de datos para identificar, específicamente, a aquellas intoxicaciones vinculadas con el uso de agroquímicos en labores agrícolas, entre otros problemas. El análisis dejó en evidencia la necesidad de establecer mejoras en el diagnóstico, en la notificación, así como en la carga de información al sistema informático de salud para mejorar la posterior utilización de los datos por parte de los usuarios que accedan a éstos.
Laktasyonu Arttıran Yöntemler: Hipnoemzirme
Authors: KİLCİ Şeyma , SEVİL Ümran
Published: November 2021

Kaygı, yorgunluk, stres, ağrı gibi faktörler doğum sonu annelerde laktasyonu etkilemektedir. Özellikle son dönemlerde annelerin sütüm yetecek mi düşüncesi bilinçaltına olumsuz mesaj göndererek laktasyonu etkileyebilmektedir. Laktasyonu artırmaya yardımcı farklı non-farmakolojik yöntemler (meme ucu stimülasyonu, meme masajı, ılık duş alma, memeye ılık kompresler uygulama, süt arttırıcı bitki çayları vb) bulunmaktadır. Annelere hem laktasyonu artırmak hem de sakin ve rahat bir duruma ulaşmalarında yardımcı olmak için yapılabilecek bir başka non-farmakolojik yöntemde hipnoemzirmedir. Hipnoemzirme, annelerin gevşemesine, sakinlik elde etmesine, kan basıncı ve kalp atımını azaltmaya ve nefes alma faaliyetlerini yavaşlatmaya yardımcı meditasyon şeklinde gevşeme tekniklerinden biridir. Yumuşak ve hafif dokunuşlar, vücut için sakinleştirici bir etki sağlar ve pozitif olumlamalar ile birlikte laktasyonun başlamasına ya da artmasına yardımcı olur. Bu derleme hipnoemzirmenin tanıtılması, geliştirilmesi ve klinik araştırmalarla destelenerek uygulamalarda kullanılması amacıyla yapılmıştır
The formation of a system of Cossack and mountain forest services in the territory of modern Karachay-Cherkessia in the pre-revolutionary period
Authors: Карабашева Диана Аликовна
Published: November 2021

В статье освещается один из важных аспектов экономической истории, связанный с отраслью лесного хозяйства на территории современной Карачаево-Черкесской республики. Хищническая эксплуатация лесных богатств региона во второй половине XIX в. со стороны местного горского и казачьего населения детерминировала государственное и общественное вмешательство в данную сферу, главной целью которого было не только желание предотвратить экологическую катастрофу и упорядочить пользование лесами, но и учесть потребности населения, сохранить рентабельность лесного хозяйства. В центре внимания автора находятся аспекты, относящиеся к возникновению системы войсковых и общественных лесничеств в имперский период. Рассматриваются вопросы, связанные с финансовой деятельностью данных структур, отмечается динамика их расходов и доходов, указывается штатный состав лесничеств, акцентируется внимание на проблемах кадрового состава и существовании коррупционных схем. Данная работа впервые освещает возникновение в нагорной части Верхней Кубани природоохранных структур, их правовые виды, комплекс их функций (административных, защитных, надзорных, технических, хозяйственных и др.), нормативную основу, содержание и ареал их деятельности. Автор отмечает основные проблемы отрасли, характер и динамику освоения лесных ресурсов региона, эффективность деятельности службы охраны лесов.

The article highlights one of the important aspects of economic history related to the forestry industry in the territory of the modern Karachay-Cherkess Republic. The predatory exploitation of the region's forest wealth in the second half of the 19th century on the part of the local mountain and Cossack population determined state and public intervention in this area. Its main goal was not only the desire to prevent an environmental disaster and streamline the use of forests, but also to take into account the needs of the population, to preserve the profitability of forestry. The author focuses on aspects related to the emergence of a system of military and public forest services during the imperial period. The paper deals with the issues related to the financial activities of these structures, the dynamics of their expenses and income, the staff of forest services, attention is focused on the problems of personnel composition and the existence of corruption schemes. This work for the first time highlights the emergence of environmental protection structures in the upland part of the Upper Kuban, their legal types, the complex of their functions (administrative, protective, supervisory, technical, economical etc.), the normative basis, content and range of their activities. The author notes the main problems of the industry, the nature and dynamics of the development of forest resources in the region, the effectiveness of the forest protection service.
O impacto de medidas restritivas devido à pandemia por COVID-19 nas concentrações de poluentes atmosféricos em cidade de médio porte
Authors: Mantovani Igor Soares , Pimenta Andressa Ferreira , Bieleski Isadora Caroline , Beal Alexandra , Martins Leila  Droprinchinski , Solci Maria Cristina
Published: November 2021

O avanço da pandemia provocada pela COVID-19, além de causar danos à saúde humana, também apresentou efeitos indiretos na qualidade do ar, apresentando melhorias significativas. A relação entre a transmissibilidade do vírus SARS-Cov-2 e a poluição do ar suscita a preocupação em estudar o impacto das medidas de proteção contra o avanço da doença na qualidade do ar. As coletas de material particulado (MP) foram realizadas em abril de 2020, período em que foram observadas medidas de restrição à circulação de veículos e sua relaxação, utilizando amostradores tipo ciclone de baixo volume para as frações MP1,0 e MP2,5. A quantificação do Black Carbon foi realizada por meio do reflectômetro (EEL 43M). As medidas adotadas para combater a COVID-19, por reduzirem fontes de emissão, contribuíram diretamente para a melhoria da qualidade do ar, resultando em uma diminuição na concentração de todos os analitos estudados neste trabalho. Houve uma variação na concentração de MP1,0 e MP2,5 de 31,5% e 27,4% respectivamente em MHL e 40,1% e 34,2% em TOU. As medidas adotadas para conter o avanço da COVID-19 contribuíram diretamente para a melhora na qualidade do ar.
Factores de riesgo, conocimiento y práctica de tamizaje para cáncer de mama en consulta externa
Authors: Gómez Lara Vilma Alejandra Gómez Lara , Flores Prado Alejandra Michelle Flores Prado , Banegas Mejía Néstor Raúl Banegas Mejía , Morales Reyes Megan Jaret , Sánchez Hernández Sussette Alexandra , Aguilar Álvarez Ligia Mercedes , Reina Martínez Luisa Elena , Norris Mencías Martha Consuelo , Díaz Cálix Omar Alejandro
Published: November 2021

El cáncer de mama es el segundo cáncer más frecuente a nivel mundial. En Honduras sigue siendo la principal causa de cáncer en las mujeres. Hay factores de riesgo modificables y no modificables. Las pruebas de tamizaje disponibles para detectarlo son: mamografía, ultrasonido, resonancia magnética, tomo síntesis y autoexamen de mama. Objetivo. Describir los factores de riesgo y evaluar el conocimiento sobre práctica de tamizaje para la detección del cáncer de mama de las mujeres que asisten a la consulta externa del Hospital Nacional Mario Catarino Rivas (HMCR) de diciembre 2019 a enero 2020. Pacientes y métodos. Estudio cuantitativo, descriptivo y transversal con una muestra por conveniencia de 100 mujeres que asistieron a la consulta externa el 19 de diciembre del 2019 y 16 de enero 2020 entre las 8 a.m. y 12m en el HMCR. Se aplicó un cuestionario antes y después de una charla educativa sobre conocimiento y pruebas de tamizaje para cáncer de mama. Se procesaron los datos en Excel® 2013 y SPSS® V.22. Resultados. El 55% tenía entre 41-60 años. El 79% tenía un índice de masa corporal mayor a 25. El 45% refirió consumo de anticonceptivos orales alguna vez en su vida. El 41% conocía menos o igual a 3 métodos de tamizaje. El 65% se había realizado el autoexamen de mama, pero sólo el 29% se lo hacía una vez al mes. Conclusión. La mayoría de la población encuestada tenía más de 3 factores de riesgo para cáncer de mama. Las pruebas de tamizaje más conocidas fueron la mamografía y autoexamen.
Coinfección por VIH y COVID 19: Reporte de Serie de Casos
Authors: Banegas Carballo Krisia María , Erazo Karen
Published: November 2021

Honduras reportó dos primeros casos de enfermedad por coronavirus (COVID19) el 11 de marzo del 2020, actualmente reporta un total de 46,365 casos confirmados con 1,465 fallecidos que estiman una tasa letalidad de 3.16%, es por esto que se ha cuestionado si la infección por virus de inmunodeficiencia humana (VIH) incrementa el riesgo de contagio y severidad de la COVID-19 debido a su riesgo de inmunosupresión. En el presente estudio de casos se incluyeron 6 pacientes con VIH coinfectados con COVID-19 tratados en el Hospital Nacional Dr. Mario Catarino Rivas (HNMCR) desde el inicio de la pandemia en marzo hasta julio del 2020. Se codificaron como P1 a P6, todos los pacientes recibían tratamiento antirretroviral, 4 de ellos en estado crítico con hipoxia severa que ameritó soporte venti- latorio y fallecieron (P2, P3, P5, P6). Un paciente (P1) en estado estable fue dado de alta tras 7 días de estancia hospitalaria. Un paciente (P4) fue asintomático. La evidencia científica aún sigue siendo escasa sobre el riesgo de contagio con el SARS-CoV-2 en pacientes con VIH. Las personas infectadas por el VIH no están protegidas de la infección por SARS-CoV-2 ni tienen un riesgo menor de padecer una enfermedad grave y por lo general, deben recibir el mismo enfoque de tratamiento aplicado a la población general. El presente trabajo se limita a la descripción de una serie de casos por lo que no se puede generalizar en todos los pacientes con VIH, sin embargo, se pretende contribuir a conocer la coinfección.
Enfermedad de Wilson: Reporte de caso
Authors: Gómez Lara Vilma Alejandra , Banegas Mejía Néstor Raúl , Reyes Urrea Mario René , Alvarez Corrales Allan Alcides
Published: November 2021

Antecedentes, la enfermedad de Wilson, también conocida como degeneración hepatolenticular, fue primeramente descrita por el neurólogo británico Kinnier Wilson en 1912. La prevalencia estimada de la enfermedad de Wilson es de 1 caso en 30,000 nacimientos en la mayoría de las poblaciones. Algunos estudios sugieren que hombres y mujeres son afectados por igual. Las manifestaciones clínicas de la enfermedad de Wilson son predominantemente hepáticas, neurológicas y psiquiátricas, y algunos pacientes pueden tener una combinación de ellas. Las Guías de Práctica Clínica de enfermedad de Wilson recomiendan penicilamina, trientina, zinc, tetratiomolibdato y dimercaprol como medicamentos. Caso clínico: se presenta un caso clínico de paciente femenina de 32 años de edad que presentó temblor en miembros superiores, progresivo, bilateral de reposo e intención, que llegó a dificultarle la escritura. Dos meses después la paciente nota trastornos de la marcha, con torpeza, lateropulsión, y posición distónica de pie izquierdo, durante la evolución se agrega hipofonía y disfagia, tanto para sólidos como líquidos, dificultando pero no impidiendo alimentación, además lentitud mental y trastorno de estado de ánimo. Se le indicó penicilamina y hubo mejoría en su sintomatología en las siguientes consultas. Conclusiones: El pronóstico para los pacientes que tienen buena adherencia al tratamiento es excelente, incluso en algunos que ya tienen enfermedad hepática avanzada por la enfermedad.
How does the viability of bone-restricted osteocytes regulate bone atrophy?
Authors: Bozec Aline , Andreev Darja , Alexander Friedrich
Published: November 2021

How does the viability of bone-restricted osteocytes regulate bone atrophy?

Osteocyte death is amplified in many bone diseases and is ubiquitous upon ageing. To date, the impact of osteocyte death on pathological bone loss is poorly studied due to the remote location of osteocytes. Within the ERC Starting Grant project “Unknown functions of Osteocyte DEath (ODE)” we will make use of new imaging and omics technologies to unravel this question.