bluuebunny/crossref_metadata_2025 huggingface dataset:
Management of Medically Compromised Prosthodontic Patients
Authors: Ghimire Pratistha , Suwal Pramita , Basnet Bishal Babu
Published: January 2022

The medical evaluation of patients considering prosthodontic treatment is a vital step in the treatment planning. The prosthodontist should be able to assess the inherent risks associated with the treatment of patients with systemic conditions. Many factors are associated with evaluating the patient’s health status and risk including the patient’s current and past medical and dental history, current and past use of medications, type of treatment, length of treatment, invasiveness of treatment, and degree of urgency of treatment. In this article, some of the systemic diseases like arthritis, cardiovascular diseases, endocrine disorders, hematologic and oncologic disease, neurologic disorders, bone disorders, pulmonary diseases, liver diseases, and chronic kidney disease that commonly affect aged individuals are reviewed. The prosthodontic considerations that should be taken care of while managing patients with these systemic conditions will also be discussed.
Liquiritin Alleviates Depression-Like Behavior in CUMS Mice by Inhibiting Oxidative Stress and NLRP3 Inflammasome in Hippocampus
Authors: Liu Chang , Yuan Dai , Zhang Chi , Tao Ye , Meng Ying , Jin Mengli , Song Wu , Wang Bingmei , Wei Lin
Published: January 2022

Objective. Central inflammation is generally accepted to be involved in the pathology of depression. We investigated whether liquiritin exerts antidepressant effects by inhibiting central NLRP3 inflammasomes. Results. The behavioral despair model and chronic unpredictable mild stress (CUMS) model in mice were established to evaluate the antidepressant action of liquiritin. In the despair model study, liquiritin (40 mg/kg) administration reduced immobility time in tail suspension test (TST) and forced swimming test (FST) without affecting locomotion activity. In CUMS model study, liquiritin (40 mg/kg, once daily for 4 weeks) significantly increased sucrose consumption and body weight of CUMS mice. The behavioral experiment results showed that liquiritin reduced the immobile time of CUMS mice in TST and FST, respectively, and increased the time spent and open arm entries in the elevated plus-maze (EPM) test. Further, the hippocampal superoxide dismutase (SOD) activity was increased in liquiritin-treated group, while malonaldehyde (MDA) decreased. Additionally, the hippocampal cytokines interleukin-18 (IL-18) and interleukin-1 beta (IL-1β) contents were reduced in the liquiritin-treated group. Further, liquiritin downregulated the expression of NLRP3 in the hippocampus of CUMS mice rather than TLR4. Besides, NLRP3 inflammasome-associated proteins caspase-1 and ASC were also downregulated. However, liquiritin did not alter the thermal stability of NLRP3 in the cellular thermal shift assay (CETSA), suggesting that its inhibition of NLPR3 was not by direct targeting of NLRP3 protein. Conclusions. Liquiritin attenuates depression-like behavior of CUMS mice and inhibited cytokines levels triggered by NLRP3 inflammasome, suggesting the antidepressant action is, at least partially, associated with antioxidant stress and inhibition of NLRP3 inflammasome activation.
Some Upper Bounds on the First General Zagreb Index
Authors: Jamil Muhammad Kamran , Javed Aisha , Bonyah Ebenezer , Zaman Iqra
Published: January 2022

The first general Zagreb index Mγ(G) or zeroth‐order general Randić index of a graph G is defined as Mγ(G) = ∑v∈Vd(v)γ where γ is any nonzero real number, d(v) is the degree of the vertex v and γ = 2 gives the classical first Zagreb index. The researchers investigated some sharp upper and lower bounds on zeroth‐order general Randić index (for γ < 0) in terms of connectivity, minimum degree, and independent number. In this paper, we put sharp upper bounds on the first general Zagreb index in terms of independent number, minimum degree, and connectivity for γ. Furthermore, extremal graphs are also investigated which attained the upper bounds.
Intelligent Measurement and Monitoring of Carbon Emissions for 5G Shared Smart Logistics
Authors: Zhang Ailing , Li Sha , Tan Lin , Sun Yingchao , Yao Fuxiao
Published: January 2022

With the upgrading of logistics demand and the innovation of modern information technology, the smart logistics platform integrates advanced concepts, technologies, and management methods, maximizes the integration of logistics resources and circulation channels, and effectively improves the efficiency of logistics transactions, but its energy consumption problem is particularly prominent. The study of intelligent measurement and monitoring of carbon emissions in smart logistics is of great value to reduce energy consumption, reduce carbon emissions in buildings, and improve the environment. In this paper, by comparing and analyzing the accounting standards of carbon emissions and their calculation methods, the carbon emission factor method is selected as the method to study the carbon emissions of the smart logistics process in this paper. The working principle of each key storage technology in the smart logistics process is analyzed to find out the equipment factors affecting the carbon emission of each storage technology in the smart logistics process, and the carbon emission calculation model of each key storage technology is established separately by using the carbon emission factor method. Meanwhile, according to the development history of energy consumption assessment, the assessment process of different stages from logistics storage energy consumption assessment to smart logistics energy consumption assessment is analyzed, and based on this, a carbon emission energy consumption assessment framework based on 5G shared smart logistics is constructed. This paper applies the supply chain idea to define the smart logistics supply chain, constructs a conceptual model of the smart logistics supply chain considering carbon emissions, and at the same time combines the characteristics of the smart logistics supply chain to analyze the correlation between the carbon emissions of the smart logistics supply chain and the related social, environmental, and economic systems.
[Retracted] Development Level Evaluation of Water Ecological Civilization in Yangtze River Economic Belt
Authors: Qi Qi , Song Shengbang
Published: January 2022

Water ecological civilization (WEC) is a key component and basic guarantee of ecological civilization. This paper sets up an evaluation index system (EIS) for WEC development (WECD) level, which covers such three dimensions as social economic development, control over total water resources and water utilization efficiency, and synthetic environmental governance and adopts set pair analysis (SPA) to measure and analyze the WECD level in Yangtze River Economic Belt (YREB) from 2010 to 2019. The results show that (1) the score of each subsystem in YREB WECD grew continuously in the sample period and poised to increase in future, (2) in general, YREB WECD level steadily increased to a relatively high level, and (3) the good development trend of YREB WECD is inseparable from the fact that YREB stepped up its efforts in capital investment, water utilization, and water environment protection and recovery. Finally, pertinent measures were put forward to further improve the YREB WECD level.
A Novel Vehicle Detection Framework Based on Parallel Vision
Authors: Zhuo Ying , Yan Lan , Zheng Wenbo , Zhang Yutian , Gou Chao
Published: January 2022

Autonomous driving has become a prevalent research topic in recent years, arousing the attention of many academic universities and commercial companies. As human drivers rely on visual information to discern road conditions and make driving decisions, autonomous driving calls for vision systems such as vehicle detection models. These vision models require a large amount of labeled data while collecting and annotating the real traffic data are time-consuming and costly. Therefore, we present a novel vehicle detection framework based on the parallel vision to tackle the above issue, using the specially designed virtual data to help train the vehicle detection model. We also propose a method to construct large-scale artificial scenes and generate the virtual data for the vision-based autonomous driving schemes. Experimental results verify the effectiveness of our proposed framework, demonstrating that the combination of virtual and real data has better performance for training the vehicle detection model than the only use of real data.
Adaptive Sparse Domain Selection for Weather Radar Superresolution
Authors: Yuan Haoxuan , Zeng Qiangyu , He Jianxin
Published: January 2022

Accurate and high-resolution weather radar data reflecting detailed structure information of radar echo plays an important role in analysis and forecast of extreme weather. Typically, this is done using interpolation schemes, which only use several neighboring data values for computational approximation to get the estimated, resulting the loss of intense echo information. Focus on this limitation, a superresolution reconstruction algorithm of weather radar data based on adaptive sparse domain selection (ASDS) is proposed in this article. First, the ASDS algorithm gets a compact dictionary by learning the precollected data of model weather radar echo patches. Second, the most relevant subdictionaries are adaptively select for each low-resolution echo patches during the spare coding. Third, two adaptive regularization terms are introduced to further improve the reconstruction effect of the edge and intense echo information of the radar echo. Experimental results show that the ASDS algorithm substantially outperforms interpolation methods for ×2 and ×4 reconstruction in terms of both visual quality and quantitative evaluation metrics.
Optimal Replenishment Strategy for Inventory Mechanism with a Known Price Increase and Backordering in Finite Horizon
Authors: Zhang Lixia , Feng Bo
Published: January 2022

For the finite horizon inventory mechanism with a known price increase and backordering, based on minimizing the inventory cost, we establish two mixed integer optimization models. By buyer’s cost analysis, we present the closed-form solutions to the models, and by comparing the minimum cost of the two strategies, we provide an optimal ordering policy to the buyer. Numerical examples are presented to illustrate the validity of the model, and sensitivity analysis on major parameters is also made to show some insights to the inventory model.
Precios de los medicamentos en Chile
Authors: De Elejalde Ramiro
Published: January 2022

Los seguros médicos en Chile no ofrecen cobertura para medicamentos siendo las familias las que pagan la mayor parte del gasto en ellos. Por esto, sus altos precios impactan directamente en el bienestar de las familias chilenas. Por esta razón, el funcionamiento de mercado de medicamentos, en particular el minorista de las farmacias, ha estado en el centro de la discusión pública. Casos de colusión como el que involucró a las tres cadenas de farmacias más grandes (Ahumada, Salcobrand y Cruz Verde) sugieren que puede existir un problema de competencia en el sector. Continuar leyendo...
NOTCH-Induced MDSC Recruitment after oHSV Virotherapy in CNS Cancer Models Modulates Antitumor Immunotherapy
Authors: Otani Yoshihiro , Yoo Ji Young , Lewis Cole T. , Chao Samantha , Swanner Jessica , Shimizu Toshihiko , Kang Jin Muk , Murphy Sara A. , Rivera-Caraballo Kimberly , Hong Bangxing , Glorioso Joseph C. , Nakashima Hiroshi , Lawler Sean E. , Banasavadi-Siddegowda Yeshavanth , Heiss John D. , Yan Yuanqing , Pei Guangsheng , Caligiuri Michael A. , Zhao Zhongming , Chiocca E. Antonio , Yu Jianhua , Kaur Balveen
Published: January 2022

Purpose:

Oncolytic herpes simplex virus-1 (oHSV) infection of brain tumors activates NOTCH, however the consequences of NOTCH on oHSV-induced immunotherapy is largely unknown. Here we evaluated the impact of NOTCH blockade on virus-induced immunotherapy.

Experimental Design:

RNA sequencing (RNA-seq), TCGA data analysis, flow cytometry, Luminex- and ELISA-based assays, brain tumor animal models, and serum analysis of patients with recurrent glioblastoma (GBM) treated with oHSV was used to evaluate the effect of NOTCH signaling on virus-induced immunotherapy.

Results:

TCGA data analysis of patients with grade IV glioma and oHSV treatment of experimental brain tumors in mice showed that NOTCH signaling significantly correlated with a higher myeloid cell infiltration. Immunofluorescence staining and RNA-seq uncovered a significant induction of Jag1 (NOTCH ligand) expression in infiltrating myeloid cells upon oHSV infection. Jag1-expressing macrophages further spread NOTCH activation in the tumor microenvironment (TME). NOTCH-activated macrophages increased the secretion of CCL2, which further amplified myeloid-derived suppressor cells. CCL2 and IL10 induction was also observed in serum of patients with recurrent GBM treated with oHSV (rQnestin34.5; NCT03152318). Pharmacologic blockade of NOTCH signaling rescued the oHSV-induced immunosuppressive TME and activated a CD8-dependent antitumor memory response, resulting in a therapeutic benefit.

Conclusions:

NOTCH-induced immunosuppressive myeloid cell recruitment limited antitumor immunity. Translationally, these findings support the use of NOTCH inhibition in conjunction with oHSV therapy.
MUC1-C Dictates JUN and BAF-Mediated Chromatin Remodeling at Enhancer Signatures in Cancer Stem Cells
Authors: Bhattacharya Atrayee , Fushimi Atsushi , Yamashita Nami , Hagiwara Masayuki , Morimoto Yoshihiro , Rajabi Hasan , Long Mark D. , Abdulla Maha , Ahmad Rehan , Street Kelly , Liu Song , Liu Tao , Kufe Donald
Published: January 2022

The oncogenic MUC1-C protein promotes dedifferentiation of castrate-resistant prostate cancer (CRPC) and triple-negative breast cancer (TNBC) cells. Chromatin remodeling is critical for the cancer stem cell (CSC) state; however, there is no definitive evidence that MUC1-C regulates chromatin accessibility and thereby expression of stemness-associated genes. We demonstrate that MUC1-C drives global changes in chromatin architecture in the dedifferentiation of CRPC and TNBC cells. Our results show that MUC1-C induces differentially accessible regions (DAR) across their genomes, which are significantly associated with differentially expressed genes (DEG). Motif and cistrome analysis further demonstrated MUC1-C–induced DARs align with genes regulated by the JUN/AP-1 family of transcription factors. MUC1-C activates the BAF chromatin remodeling complex, which is recruited by JUN in enhancer selection. In studies of the NOTCH1 gene, which is required for CRPC and TNBC cell self-renewal, we demonstrate that MUC1-C is necessary for (i) occupancy of JUN and ARID1A/BAF, (ii) increases in H3K27ac and H3K4me3 signals, and (iii) opening of chromatin accessibility on a proximal enhancer–like signature. Studies of the EGR1 and LY6E stemness–associated genes further demonstrate that MUC1-C–induced JUN/ARID1A complexes regulate chromatin accessibility on proximal and distal enhancer–like signatures. These findings uncover a role for MUC1-C in chromatin remodeling that is mediated at least in part by JUN/AP-1 and ARID1A/BAF in association with driving the CSC state.

Implications:

These findings show that MUC1-C, which is necessary for the CRPC and TNBC CSC state, activates a novel pathway involving JUN/AP-1 and ARID1A/BAF that regulates chromatin accessibility of stemness-associated gene enhancers.
Machine Learning Algorithms as a Computer-Assisted Decision Tool for Oral Cancer Prognosis and Management Decisions: A Systematic Review
Authors: Chiesa-Estomba Carlos M. , Graña Manuel , Medela Alfonso , Sistiaga-Suarez Jon A. , Lechien Jerome R. , Calvo-Henriquez Christian , Mayo-Yanez Miguel , Vaira Luigi Angelo , Grammatica Alberto , Cammaroto Giovanni , Ayad Tareck , Fagan Johannes J.
Published: January 2022

Introduction: Despite multiple prognostic indicators described for oral cavity squamous cell carcinoma (OCSCC), its management still continues to be a matter of debate. Machine learning is a subset of artificial intelligence that enables computers to learn from historical data, gather insights, and make predictions about new data using the model learned. Therefore, it can be a potential tool in the field of head and neck cancer. Methods: We conducted a systematic review. Results: A total of 81 manuscripts were revised, and 46 studies met the inclusion criteria. Of these, 38 were excluded for the following reasons: use of a classical statistical method (N = 16), nonspecific for OCSCC (N = 15), and not being related to OCSCC survival (N = 7). In total, 8 studies were included in the final analysis. Conclusions: ML has the potential to significantly advance research in the field of OCSCC. Advantages are related to the use and training of ML models because of their capability to continue training continuously when more data become available. Future ML research will allow us to improve and democratize the application of algorithms to improve the prediction of cancer prognosis and its management worldwide.
Leakage of Endotoxins through the Endotoxin Retentive Filter: An in vitro Study
Authors: Nozaki Hiroshi , Tange Yoshihiro , Inada Yoji , Uchino Takashi , Azuma Nakanobu
Published: January 2022

Introduction: Ultrapurification of dialysis fluid has enabled highly efficient dialysis treatments. Online hemodiafiltration is one such treatment that uses a purified dialysis fluid as a supplemental fluid. In this method, an endotoxin retentive filter (ETRF) is used in the final step of dialysis fluid purification, with the aim of preventing leakage of endotoxins. Sodium hypochlorite and peracetic acid are used as disinfecting agents for the dialysis fluid pipes containing the ETRF; however, the effects of these agents on ETRF membrane pores have not been fully clarified. Methods: Water permeability (flux) and endotoxin permeability were assessed in 3 types of ETRFs made with different membrane materials: polyester polymer alloy (PEPA), polyether sulfone (PES), and polysulfone (PS). High-concentration sodium hypochlorite and 2 types of peracetic acid were used as disinfecting agents, and the changes in flux and the endotoxin sieving coefficient (SC) were measured. Results: After repeated use of high concentrations of sodium hypochlorite and peracetic acid, the PEPA and PES ETRFs did not permit passage of endotoxins, regardless of their flux. However, in the PS ETRF, the flux and endotoxin SC increased with the number of cleaning cycles. No differences were observed according to the concentration of peracetic acid disinfecting agents. Conclusion: PEPA and PES ETRFs completely prevent endotoxin leakage and can be disinfected at concentrations higher than the conventionally recommended concentration without affecting pore expansion. Even new PS ETRFs have low levels of endotoxin leakage, which increase after disinfection cycles using sodium hypochlorite and peracetic acid.
Mitigation of Blood Load Impact in Patients with Subarachnoid Hemorrhage by Cisternal Lavage
Authors: Fistouris Panagiotis , Scheiwe Christian , Grauvogel Juergen , Csók István , Beck Juergen , Reinacher Peter C. , Roelz Roland
Published: January 2022

Object: The initial amount of subarachnoid and ventricular blood is an important prognostic factor for outcome in patients with aneurysmal subarachnoid hemorrhage (aSAH). In this comparative study of an unselected aSAH-population, we assess the modifiability of these factors by implementation of blood clearance by cisternal lavage. Methods: All patients with aSAH treated in our department between October 2011 and October 2019 (8 years, n = 458) were included in our study. In the first 4-year period (BEFORE, n = 237), patients were treated according to international guidelines. In the second 4-year period (AFTER, n = 221), cisternal lavage methods were available and applied in 72 high-risk patients (32.5%). The cisternal and ventricular blood load was recorded by the Hijdra score. Multivariable regression models were used to assess the prognostic significance of risk factors, including blood load, in relation to common aSAH characteristics in both study groups. Results: Worse neurological outcomes (mRS > 3) occurred in the BEFORE population with 41.45% versus 30.77% in the AFTER cohort, 6 months after aSAH (HR: 1.59, 95% CI 1.08–2.34, p = 0.01). Admission WFNS grade, comorbidities (Charlson Comorbidity Index), herniation signs, concomitant intracerebral hemorrhage, and the development of delayed cerebral infarction were strongly associated with poor outcome in both study groups. Intraventricular and cisternal blood load and, particularly, a cast fourth ventricle (Cast 4) represented strong prognosticators of poor neurological outcome in the BEFORE cohort. This effect was lost after implementation of cisternal lavage (AFTER cohort). Conclusion: Cisternal and ventricular blood load – in particular: a Cast 4 – represent important prognosticators in patients with aSAH. They are, however, amenable to modification by blood clearing therapies.
Indicadores de base econômica
Authors: Avila Cristian Orlando , Moreno Carlos Julio , Oliveira Nilton Marques de
Published: January 2022

Este artigo analisa indicadores de base econômica nas regiões da Colômbia e do Brasil. A teoria da base econômica explica as relações inter-regionais que abrangem a mobilidade de pessoas, bens e serviços. Da mesma forma, avalia os impactos relevantes desses fluxos entre as regiões e a economia de referência. Como procedimentos metodológicos, foram utilizados dois indicadores de análise regional; o Quociente de Localização (QL) e o Coeficiente de Associação Geográfica (CAG) e estimou-se o Multiplicador Básico de Emprego (MEB), indicando como resultados os ramos de atividade mais especializados (chamados de atividades básicas) em todas as regiões colombianas e brasileiras analisadas. Os resultados do QL e do CAG obtidos refletem que a economia das regiões colombianas continua a depender de três atividades básicas: Agricultura, Construção e Comércio, uma atividade primária, uma secundária e uma terciária, respectivamente. Enquanto no Brasil não mais que três regiões brasileiras têm a mesma atividade motora. A região Sudeste é a que concentra mais atividades de base econômica; 19 de 25 e gera mais empregos do que as outras regiões brasileiras, com nove empregos não básicos para cada emprego básico criado. Finalmente, fica evidente que enquanto no Brasil as regiões que marcam a economia nacional são as que margeiam o Oceano Atlântico - Sudeste e Sul - na Colômbia a região que faz fronteira com o Oceano Atlântico, não. É a região Centro-Oeste - região Andina - que estimula a geração de aproximadamente 27 empregos não básicos para cada emprego básico criado.
Pensar a realidade se queres transformá-la
Authors: Coutinho Joana Aparecida
Published: January 2022

A resenha aqui apresentada trata do livro Historia y Filosofía, de Caio Prado Jr., autor clássico do pensamento crítico brasileiro, agora traduzido ao espanhol pela Editorial Último Recurso (Argentina) em parceria com o Núcleo Práxis-USP. A tradução do português para o espanhol, lançada em 2020, reúne textos originais selecionados da obra de Caio Prado Jr, marxista brasileiro. A organização do livro foi coordenada, pelo filósofo Yuri Martins, e é fruto de um trabalho coletivo cuidadoso de seleção e tradução empreendida por cerca de vinte pesquisadores de diversas áreas: historiadores, cientistas sociais, linguistas, economistas e até psicólogos, membros e colaboradores do Núcleo Práxis da USP, entidade político-acadêmica que ao longo da última década tem demonstrado compromisso com a difusão do conhecimento crítico e a formação política popular.
Integração da infraestrutura verde no ordenamento da cidade de Lichinga: potencialidades e condicionantes
Authors: Masquete Júlio Ambrósio , Chande Goldfredy Manuel Chitile
Published: January 2022

A produção do espaço nas cidades moçambicanas é caracterizada pela supressão progressiva das áreas verdes, diante da arborização urbana inexistente ou inadequada. A partir do enfoque qualitativo, guiado pela consulta bibliográfica e  documental na observação direta e do uso de recursos cartográficos, o artigo debruça sobre as potencialidades e  possibilidades da integração da Infraestrutura Verde como estratégia de ordenamento e desenvolvimento do território,  centrado no contexto do Município da Cidade de Lichinga (Moçambique). Considera-se importante inserir a Infraestrutura Verde no planeamento das cidades para possibilitar maior qualidade de vida, podendo constituir uma alternativa para mitigar a degradação da paisagem urbana, além de proporcionar serviços ambientais essenciais para a sustentabilidade das cidades e resiliência das comunidades. Daqui reside a importância de uma abordagem de planeamento e gestão do território que a partir de um enfoque colaborativo prioriza a delimitação de áreas para implantação da Infraestrutura Verde, entendido como fator de ordenamento do território e desenvolvimento do município. A delimitação das áreas para implantação da Infraestrutura Verde deverá observar as características da base biofísica do território e levar em consideração os problemas ambientais prevalecentes, bem como os interesses e preocupações dos segmentos da população
Greek High Culture in Hellenistic and Early Imperial Bithynia
Authors: Bowie Ewen
Published: January 2022

The article attempts to set out evidence for various forms of Greek high culture in Bithynia from the fifth century BC to the middle of the third century AD, taking as a cut-off point the tetrarchic period in which Diocletian’s choice of Nicomedia as a capital had a marked impact on its and other Bithynian cities’ cultural life. The preliminary prosopography lists representatives of Greek culture by city, subdividing into the categories doctor, grammaticus, historian, philosopher, poet, rhetor or sophist, and scholar (with a sprinkling of other performers). Only Nicaea, with 30 names, makes a strong and persistent showing; of other cities only Nicomedia musters more than 10 names, though Prusa and Prusias ad mare produce several doctors. Prusias ad Hypium, by contrast, can boast only a single philosopher, perhaps a rhetor who moved to Nicaea, and a visiting tragic performer.
Spectators and Spectacle in Quintus’ Posthomerica
Authors: de Jong Irene J.F.
Published: January 2022

Quintus’ literary reputation is on the rise, in the wake of a general reappreciation of late antique literature. In my article I discuss Quintus’ use of embedded focalization: when we look at events through the eyes of one of the characters. Quintus uses this narrative device both in the same way as Homer, but also in original new ways. One such new way is the serial use of embedded focalization at the moment of arrival of a champion. The ample use of embedded focalization can be added to the list of stylistic features which contribute to the well-known visual aesthetics of late antique poetry, such as ekphrasis, miniaturization, enumeration, and the juxtaposition of episodic scenes. But I also argue that Quintus through the ubiquitous presence of spectators frames the action of his story as a spectacle, a race or gladiatorial show, which gods and characters and hence his narratees, watch as if sitting in an amphitheatre or circus.
Death and the Maiden in Philostratus, About Apollonius of Tyana 4.45
Authors: Praet Danny
Published: January 2022

The Vita Apollonii leaves much open to interpretation. In 4.45 Philostratus tells us about a young woman who was thought dead by her family and the whole of Rome. Apollonius whispers something in her ear and the maiden starts talking again. The narrator comments it was impossible for the bystanders and still is impossible for him to say whether the girl was really dead or not: whether it was a case of Scheintod which proved Apollonius’s extraordinary powers of observation or whether it was a resurrection-miracle which would signal a special ontological status for ‘the man’ from Tyana. In his suspension of judgment, Philostratus uses the words arrhêtos hê katalêpsis combining a technical term from Stoic epistemology (katalêpsis) with a concept related to the Mysteries (arrhêtos). We discuss the Philostratean interpretative strategies, link them to the Pythagorean tradition of selective communication, and read the reference in this chapter to the story of Alcestis to the epistemological debates between Stoics and Skeptics about the limits of human wisdom.
Greek Migrant Literature in the Early Roman Empire
Authors: de Jonge Casper C.
Published: January 2022

This article argues that the concept of migrant literature, developed in postcolonial studies, is a useful tool for analysing Greek literature of the Early Roman Empire (27 BC-AD 68). The city of Rome attracted huge numbers of migrants from across the Mediterranean. Among them were many writers from Hellenized provinces like Egypt, Syria and Asia, who wrote in Greek. Leaving their native regions and travelling to Rome, they moved between cultures, responding in Greek to the new world order. Early imperial Greek writers include Strabo of Amasia, Dionysius of Halicarnassus, Nicolaus of Damascus, Timagenes of Alexandria, Crinagoras of Mytilene, Philo of Alexandria and Paul of Tarsus. What connects these authors of very different origins, styles, beliefs, and literary genres is migrancy. They are migrant writers whose works are characterized by in-betweenness, ambivalence and polyphony.
Grammarians and Emperors
Authors: Jones Christopher P.
Published: January 2022

The Greek γραµµατικός combined several functions: as editor and expounder of texts, linguist, librarian, lecturer, courtier and sometimes as ambassador for his monarch or city. In due course Latin-speaking grammatici applied philological skills developed at Alexandria to their own literature, and served as librarians in the great libraries of the imperial period. The present paper studies some Greek γραµµατικοί active in Rome, particularly Alexander of Cotiaeon, appointed by Antoninus Pius as tutor to the princes Marcus and Lucius, and also the teacher of Aelius Aristides. As Aristides’ tribute to him shows, Alexander was not only a notable critic and influential teacher, but acted as a benefactor (εὐεργέτης) of his native city, in this respect comparable to the sophists who were his contemporaries.
First Atlantic record of the rare infaunal shrimp Salmoneus erasimorum Dworschak, Abed-Navandi & Anker, 2000 (Malacostraca: Decapoda: Alpheidae)
Authors: D’ACOZ CÉDRIC D’UDEKEM , GULLY FLORENCE , COCHU MARC , ANKER ARTHUR
Published: January 2022

The rare symbiotic alpheid shrimp Salmoneus erasimorum Dworschak, Abed-Navandi & Anker, 2000 was previously known from a single specimen collected with a suction pump on the Croatian coast in the Adriatic Sea, together with its host, the ghost shrimp, Gilvossius tyrrhenus (Petagna, 1792). A second record of S. erasimorum is presented here, with a diagnosis and the first colour photographs, based on a single specimen collected in northern Brittany, France, also with a suction pump, but without its host. This is also the first record of the species on the European coast of the Atlantic Ocean. An annotated list and a key to the species of Salmoneus currently known from the eastern Atlantic and the Mediterranean Sea are provided.
Alcolyra, a new genus of leucosiid crab (Crustacea: Decapoda: Brachyura) from India
Authors: TRIVEDI JIGNESHKUMAR N. , MITRA SANTANU , NG PETER K. L.
Published: January 2022

The identity of Philyra alcocki Kemp, 1915 (Leucosiidae), a species described from Chilika Lake, India is clarified. The redescription of lectotype male and examination of fresh material collected from Chilika Lake, Odisha state of India revealed that P. alcocki is significantly different morphologically from members of Philyra senso stricto and other allied genera in possessing two tuberculated rows on the branchial region of carapace, and a well-developed tubercle on male thoracic sternite 5 on either side of the sternopleonal cavity. Therefore, a new genus Alcolyra n. gen. is established herewith for the species.
Cerium-oxide-loaded poly(ɛ-caprolactone) hydrogel wound dressing for cutaneous wound healing and antimicrobial treatment in burn wound infection: Development and detailed biological evaluation
Authors: Wei Wei , Xing Liang , Feng Jianke
Published: January 2022

Wound dressing materials are essential in wound healing care management. In addition to their supportive effect on the care management, polysaccharides and metal oxide nanoparticles actively contribute to the healing process. CeO2 nanoparticles can promote wound healing through
oxidative damage in the wound environment against elevated levels of reactive oxygen species. Therefore, it is necessary to develop multi-functional hydrogel wound dressing materials to stimulate wound healing. In this study, a CeO2-loaded poly(ɛ-caprolactone)/PEC polymeric
hydrogel was fabricated as a cutaneous wound-healing material. The in-vitro cytotoxic and wound healing activities were analyzed using the fabricated material in mice. A histological examination showed that the nanofibrous material accelerated the reepithelialization and provided an
excellent collagen deposition. In addition, the prepared hydrogels were tested against S. aureus and E. coli. Our results evidence the unique characteristics of the hydrogel wound dressing material exhibiting antibacterial and antioxidant activities and good biocompatibility
and healing efficiencies by enhancing the reepithelialization and granulation formation and effectively accelerating the wound healing to prevent skin infections.
Preparation of electrochemically deposited nickel—cobalt nanocomposite coating and research on its corrosion resistance
Authors: Zhang Yu , Song Ruijian , Zhang Xiang
Published: January 2022

Alloying as a way of improving material properties has really gained a lot of global attention over the past few years. Alloying majorly improves physicochemical, electrochemical, thermal, and mechanical and corrosion resistance of a parent material. In this work, electrodeposition
using a sulphamate electrolytic cell under varied concentrations of the secondary phase of cobalt. Characterization of the alloy was achieved using scanning electron microscopy (SEM), optical microscopy (OM), and X-ray diffraction (XRD) techniques. Corrosion resistance was investigated using
potentiometric and impedance tests, reported, and well explained.
Lower limb biomechanical characteristics in patients with diabetic foot: Analysis and efficacy of modified orthopedic insoles
Authors: Kong Yutao , Ma Xianzhong , Ma Zhen , Tao Hongxia , He Yanning , Kong Yujuan
Published: January 2022

We studied biochemical characteristics of the lower limbs of patients with diabetic foot (DF) to develop custom orthopedic insoles. In this study of 88 patients with diabetes, 58 had a normal foot appearance, 18 had plantar calluses, and 12 had valgus feet. The maximum pressure applied
to the left and right plantar of patients with DF is under the third metatarsal, and the peak areas of the left and right feet are below the first metatarsal. Pain and American Orthopedic Foot and Ankle Society scores were reduced after one year of wearing modified orthopedic insoles versus
unmodified insoles. After one year of wearing the insole, the pressure was reduced in the left and right feet of both groups, but the intervention group showed a more significant reduction than the controls. The swing time was shorter in the intervention group and the incidence of DF ulcers
was 6.81% higher in the control group. Thus, lower limb biomechanics differ in patients with DF, most of who experience calluses and hallux valgus. Modified orthopedic insoles provide improved sole pain, ankle-foot joint function, and distribution of plantar pressure, and incidence of DF ulcers.
Study on corrosion resistance of superhydrophobic surface on aluminum alloy
Authors: Wu Ruomei , Wu Shuai , Jiang Haiyun , Chang Zigong , Yuan Zhiqing , Chen Qinghua
Published: January 2022

Anti-corrosion of aluminum alloys with different roughness were researched in this study. To further verify the relationship between anti-corrosion and surface roughness, surface with micro structure alloy was successfully fabricated via anode oxidation on aluminum. The water contact
angle of aluminum alloy surface after coating polypropylene film was 154° and sliding angle was 3°. The micro-nano structure was constructed by adding nano-SiO2. The contacts angle of surface was 165° and the sliding angle was 1.8°. The superhydrophobic samples were
used to test corrosion resistance. Compared with aluminum coated with unmodified film, the corrosion potential for modified superhydrophobic aluminum alloy increased by about 0.05 V. When nano-SiO2 particles were added, the corrosion resistance for the sample was also improved.
Towards a Theory of the Racialization of Space
Authors: Tuttle Steven
Published: January 2022

Urbanists and race scholars have been attentive to issues relating to race and space for over 100 years. Though some scholars allude to how race is spatialized or space is racialized, that is, to say race is constructed in space and space is inscribed with race, a transportable and multifaceted theory of the racialization of space has yet to emerge. This paper advances a theory integrating racialization theory and Lefebvre’s trialectic theory of the social production of space. I consider how physical, mental, and social facets of space constitute intersecting “racial projects” in the context of societies in which race plays a determinative role. I illustrate this perspective pointing to findings from studies approaching issues of race and space from a variety of vantage points and conclude with suggestions for the further application of this theory.
Inpatient Type 1 Thyroplasty Versus Injection Laryngoplasty for Vocal Fold Movement Impairment After Extent type I and II Aortic Repair
Authors: Pinzas Lauren A. , Chen Diane W. , Liou Nelson Eddie , Donovan Donald T. , Ongkasuwan Julina
Published: January 2022

Importance:

Vocal fold motion impairment (VFMI) due to neuronal injury is a known complication following thoracic aortic repair that can impair pulmonary toilet function and post-operative recovery.

Objective:

To demonstrate clinical outcomes of patients undergoing inpatient vocal fold medialization for VFMI after aortic surgery.

Design:

A 15-year retrospective chart review (2005-2019) of 259 patients with postoperative VFMI after thoracic aortic surgery registry was conducted. Data included demographics, surgery characteristics, laryngology exam, and postoperative clinical outcomes. Medialization procedures consisted of type 1 thyroplasty and injection laryngoplasty.

Setting:

Tertiary care hospital

Participants:

Two hundred and fifty-nine patients (median age 61, 71% male) with VFMI post-thoracic aortic repair met inclusion criteria; inpatient vocal fold medialization was performed for 203 (78%) patients. One hundred and twenty-six. (49%) received type 1 thyroplasty and 77 (30%) received injection laryngoplasty procedures at a median 7 days (IQR 5-8 days) from extubation.

Main Outcomes:

Primary study outcome measurements consisted of median LOS, median ICU LOS, complications intra- and postoperatively, and pulmonary complications (post-medialization bronchoscopies, pneumonia, tracheostomy, etc.).

Results:

Post-medialization bronchoscopy rates were significantly lower in the medialization (n = 11) versus the non-medialization group (n = 8) (5% vs 14%, P = .02) and significantly higher in the injection laryngoplasty group (n = 77) versus thyroplasty group (n = 126) (10% vs 2%, P = .02). Further analysis revealed no significant difference in overall LOS and pulmonary complications between the techniques.

Conclusion:

Inpatient thyroplasty and injection laryngoplasty are both effective vocal fold medialization techniques after extent I and II aortic repair. Thyroplasty may have a small pulmonary toilet advantage, as measured by need for post-medialization bronchoscopy, compared to injection laryngoplasty.
Factors Affecting Compliance With Myringotomy Tube Follow-up Care
Authors: Soh Helen H. , Keefe Katherine R. , Sambhu Madhav , Baul Tithi D. , Karst Dillon B. , Levi Jessica R.
Published: January 2022

Objective:

Myringotomy and tube insertion is a commonly practiced procedure within pediatric otolaryngology. Though relatively safe, follow-up appointments are critical in preventing further complications and monitoring for improvement. This study sought to evaluate the factors associated with compliance of post-myringotomy follow-up visits in an urban safety-net tertiary care setting.

Methods:

This study is a retrospective chart review conducted in outpatient otolaryngology clinic at an urban, safety-net, tertiary-care, academic medical center. All patients from ages 0 to 18 who received myringotomy and tube placement between February 3, 2012, to May 30, 2018 at the aforementioned clinic were included.

Results:

A total of 806 patients had myringotomy tubes placed during this period; 190 patients were excluded due to no visits being scheduled within 1 and 6 month visit windows post-operatively, leaving 616 patients included for analysis. Of 616 patients, 574 patients were seen for the 1-month visit, (42 patients did not have follow-up visits within the 1-month window), and 356 patients were examined for the 6-month visit (260 patients did not schedule follow-up visits within the 6-month window). For the 1-month follow-up visits post-procedure, only race/ethnicity type “Other” was associated with lower no-show rates (OR = 0.330, 95% CI: 0.093-0.968). With the 6-month follow-up visits, having private insurance (OR = 0.446, 95% CI: 0.229-0.867) and not having a 1-month visit scheduled (OR = 0.404, 95% CI: 0.174-0.937) predicted lower no-show rates.

Conclusion:

No meaningful factors studied were significantly associated with compliance of short-term, 1-month visits post-myringotomy. Compliance of longer-term, 6-month post-operative visits was associated with insurance type and previous visit status.
Chronic Laryngotracheal Granulomatous Disease Secondary to Sporothrix schenckii in an Immunocompromised Patient
Authors: Kenny Hannah , Dougherty Michael , Churnin Ian , Early Stephen , Gupta Akriti , McGarey Patrick O.
Published: January 2022

Objective:

To describe a rare presentation of laryngotracheal granulomatous disease secondary to sporotrichosis.

Methods:

The authors report a case of laryngeal sporotrichosis in an immunocompromised patient, with accompanying endoscopic images and pathology.

Results/case:

A 72-year-old immunocompromised female with a history of rose-handling presented with a year of hoarseness and breathy voice. Flexible nasolaryngoscopy showed diffuse nodularity; biopsy of the lesions demonstrated granulomatous inflammatory changes, and fungal culture grew Sporothrix schenkii. Long-term itraconazole treatment was initiated, with improvement in dysphonia and few residual granulomas on follow-up examination.

Conclusion:

When evaluating granulomatous disease of the airway, a broad differential including infectious or inflammatory etiologies should be considered, especially in immunocompromised patients. Adequate tissue samples should be collected to facilitate special staining. The current recommendations for laryngeal sporotrichosis include treatment with a prolonged course of itraconazole.
Investigation of ballistic performance on 3D compound structure fabric by finite element analysis
Authors: Yang Dan , Wei Qingsong , Chen Xiaogang , Li Jinchun
Published: January 2022

Ballistic performance and moldability are two important properties for 3D curved-surface ballistic applications. However, these two properties are contradictory to each other and impossible to improve at the same time, which is a technical issue that needs to be solved urgently in the research for ballistic materials for 3D curved-surface ballistic applications. In order to solve this issue, a new 3D compound structure fabric has been developed as part of our former research and has been shown to provide better ballistic performance with equivalent moldability compared to 3D angle-interlock fabric—a well-known 3D material for 3D curved-surface ballistic applications. Nevertheless, the ballistic performance of this new fabric itself is not clear, and further research is necessary. In this study, the ballistic performance of this new 3D compound structure fabric was investigated via the finite element analysis (FEA) model to examine energy absorption and penetration resistance. A ballistic test was also carried out to verify the results of the FEA model, and this demonstrated that the theoretical model was consistent with the experimental results.
A modified resistance to compression (RtC) test for evaluation of natural fiber softness
Authors: Yu Hao , Hurren Christopher , Liu Xin , Gordon Stuart , Wang Xungai
Published: January 2022

Comfort is a key feature of any clothing that relates significantly to softness of the fiber, yarn and fabric from which is it constructed. A known softness assessment method for fibers is the resistance to compression test. This traditional test only provides a single force value for the resistance of a loose fiber sample using a fixed mass under compression. In this research, a modified resistance to compression test was introduced to show the effects of repeated compression, providing more information about the softness and resilience of selected fibers. Three different natural fiber types, including wool, cotton and alpaca were compared using this new approach. The results showed compression profiles were quite different for different fiber types as well as for the same fibers with different diameters. While the diameters of the wool and alpaca samples were similar (18.5 μm), the modified resistance to compression values were significantly higher for wool (with a peak value at 9.5 kPa compared to 2.1 kPa for alpaca). Cotton was different from wool and alpaca but showed a similar modified resistance to compression value (10.4 kPa) to wool. During cycles of compression, modified resistance to compression peak values decreased slightly and then tended to be constant. Even though the structures of wool, cotton and alpaca were quite different, there was no significant difference in the magnitude of decline in modified resistance to compression peak values. This means that the modified resistance to compression test is able to provide additional information on the resilience characteristics of different natural fibers, and can reveal the resistance behavior of fiber samples during cyclic compression.
Extending Design Thinking, Content Strategy, and Artificial Intelligence into Technical Communication and User Experience Design Programs: Further Pedagogical Implications
Authors: Tham Jason , Howard Tharon , Verhulsdonck Gustav
Published: January 2022

This article follows up on the conversation about new streams of approaches in technical communication and user experience (UX) design, i.e., design thinking, content strategy, and artificial intelligence (AI), which afford implications for professional practice. By extending such implications to technical communication pedagogy, we aim to demonstrate the importance of paying attention to these streams in our programmatic development and provide strategies for doing so.
Platelet rich fibrin: A novel treatment for trophic ulcer in Hansen's disease
Authors: Dorjay Konchok , Tandon Sidharth , Singh Ajeet , Sharma Satish , Sardana Kabir
Published: January 2022

Patients with Hansen's disease are liable to develop non-healing trophic ulcers. The aim of this study was to determine the efficacy of autologous platelet rich fibrin (PRF) applied at weekly intervals in the management of trophic ulcers. The mean age of the patients, duration and size of ulcer were 44.3 years, 7.4 months and 6.25cm2 respectively. After the third sessions of weekly dressing, there was a significant reduction in the ulcer area (p value  =  0.015). All ulcers healed by a maximum of six weeks. No adverse events were noted. PRF thus seems a feasible, safe, simple and cost-effective treatment method.