bluuebunny/crossref_metadata_2025 huggingface dataset:
Fair Value of Pancasila in the Framework of Criminal Code Renewal
Authors: Ginting Yuni Priskila , Wartoyo Franciscus Xaverius
Published: January 2024

Pancasila is the ideological foundation of the Indonesian state that guarantees the unity and integrity of Indonesians entering the era of globalization. Current Indonesian criminal law is obsolete because it does not consider Indonesia's philosophical, sociological, and cultural values and does not follow the changing mindset of modern criminal law. Social policy must be woven into and placed in a carefully integrated social plan, especially to prevent unwanted access related to crime. Indonesian criminal law will continue to apply colonial values that are not based on Pancasila values. The codification of laws that live in society is regulated specifically for public awareness of the potential for the law that can be used as a reference for regional regulations. The basic idea of Pancasila's balance is based on the religious moral paradigm, the human paradigm, the nationality paradigm, the democracy and wisdom paradigm, and the social justice paradigm. Justice is an abstract value that must be realized in the form of legal norms to realize these values in social life without ignoring religious law, customary law, and Western law. This does not correspond to the value contained in Pancasila.
Owner Estimate of Rig Contracts in Oil and Gas Business According to Legal Certainty Principles
Authors: Radjagoekgoek Robert Pangihutan
Published: January 2024

As one of the vital and strategic natural resources and vital role that impact society, oil and gas is one of state revenue sources to support national development. To implement Article 33 of the 1945 Constitution, to obtain people welfare and prosperity, Oil and Gas Law No 22, 2001 mandated Special Task Force for Upstream Oil and Gas Business Activities to oversee upstream activity done by oil and gas contractors. Contractors conduct rig procurement processes with their Owner Estimate in alignment to Presidential decree No 12, 2021 and Summary of Procedural Guidelines of 007, 2017.By this reason, legal certainty is needed to deal with problems at implementation level. Two legal issues research, regulation and preparation implementation of Owner Estimate  Value in Rig contract. The research analysis is using normative juridical which are supported by empirical studies. Owner Estimate  preparation guidelines provide multiple interpretations, inconsistencies and a legal vacuum. In practice, problems related to aspects of legal certainty, Owner Estimate offers are not confidential and/or confidential, extreme price cut due to offers below 80% of Owner Estimate are being allowed, the existence of negotiations even though the price offer is already the lowest and below Owner Estimate . It opens for conspiracy in the procurement. It is necessary to amend Perpres and Procedural Guidelines of Special Task Force for Upstream Oil and Gas Migas Number 007 achieving compliance to the principles of agreement, legal certainty and fair business. Regulation change will provide legal certainty, efficiency and effectiveness so Special Task Force for Upstream Oil and Gas Migas, oil and gas contractors and Rig Providers can conduct upstream business activities properly, optimally to support Indonesian social welfare.

 
Tax Court Decisions as the Ultimum Remedium for Taxpayers
Authors: Gunawan Edy
Published: January 2024

Taxes obtained can directly finance all state activities. State revenues, while coming from tax revenues, are also obtained from revenues outside of taxes which consist of 3 parts, which can be seen as income, capital or money to finance total government activities as shown in Law Number 17 of 2003 concerning State Finance, which can be explained in principle as follows. First, State revenues are derived from tax revenues. Second, non-tax government revenue. Thirdly, government revenue from grants. The third principle is referred to as state revenue from the tax sector and is still the largest source of revenue for state revenue. Research objectives in this paper are issues concerning taxation provisions; the application of the ultimum remedium is highly dependent on the prevailing priority scale with its main emphasis on optimizing state revenue, and not on the so-called criminal aspect; with the main reason being that the perpetrators of tax crimes should be responsible and continuously return or repair all losses incurred as a result of their mistakes. The method used is normative legal research by elaborating field data with secondary data in the form of primary, secondary and tertiary legal materials to be analyzed qualitatively. The results to be achieved in this study are willing to develop an overall understanding of tax court decisions as an ultium remedium effort for taxpayers. The application of the ultimum remedium principle directly is to increase state revenue, especially revenue in the sector.
Breach of Non-Competition Clause in Franchise Agreements Related to Unfair Business Competition
Authors: Indrawati Etty , Widiyastuti Y. Sari Murti
Published: January 2024

The non-competition clause in the franchise agreement is the franchisee's commitment not to run a similar business or potentially become a competitor to the franchisor's business within a certain period as a form of protection of the franchisor's intellectual property rights and appreciation for the transfer of know-how that the franchisor has carried out in the form of knowledge, concept, and experience to the franchisee. There are two purposes of this article. First is to explore and analyze cases of breach of the non-competition clause in franchise agreements in Indonesia carried out by franchisees can be qualified or not as a form of unfair business competition as regulated in Article 1 number 6 Law Number 5 of 1999 concerning Prohibition of Monopolistic Practices and Unfair Business Competition. Second is to investigate the legal remedies taken by the franchisor against the franchisee who breaks the non-competition clause in the franchise agreement. This research project uses qualitative method. This research involved respondents and informants from business owners of national franchisors. There are two results of this study. First, breaking non-competition clauses in franchise agreements, which have been read before signing, can qualify as unfair business competition. Second, if a franchisee or former franchisee breaks a non-competition clause, it is necessary to communicate with the violating party first before giving a summons/warning. Moreover, if it is still not heeded, the franchisor can file a lawsuit in court or submit a complaint to The Indonesia Competition Commission (KPPU).
 
HOLTEKAMP JAYAPURA BRIDGE CONSTRUCTION PROJECT: THE ANALYSIS OF RAW MATERIAL SUPPLIERS’ SELECTION
Authors: Pertiwi Karunia Ika , Gusminto Eka Bambang , Musmedi Didik Pudjo
Published: January 2024

The purpose of this study is to determine the priority of raw material suppliers in Holtekamp Jayapura bridge construction project. Data collection techniques include an interview and a questionnaire conducted with 3 (three) expert respondents using a comparison scale of 1-9. A total of 4 (four) criteria have been examined in this research, namely price, quality, shipping speed, and product capacity. This study included 8 (eight) alternative suppliers. The method applied was the Analysis Hierarchy Process (AHP) using Expert Choice V.11 software. The results revealed that the price criteria ranked first, the quality criteria ranked second, the criteria for sending speed ranked third, and the weight and product capacity criteria ranked fourth. Accordingly, Agung M, Sultan, SKB, Youtefa, Bumi Infrastruktur, Bintang M, Simpama Dwi, and Rajawali rank highest among raw material suppliers in the order of 1-8. Thus, it is indicated that Agung M, Sultan, and SKB are the 3 (three) best suppliers that the company should choose.
EFEKTIVITAS PERIKLANAN MOBIL TOYOTA DI MAKASSAR
Authors: Kurniaty Kurniaty , Rivai Fadly
Published: January 2024

Peneltian ini difokuskan pada kegiatan pemasaran yang terkait dengan strategi periklanan dalam upaya mengoptimalkan efektivitas periklanan guna pencapaian keputusan pembelian. Fokus penelitian ini adalah memperolah bukti empirik tentang kinerja efektivitas periklanan mobil Toyota dan indikator-indikator efektifitas periklanan yang mempengaruhi keputusan pembelian mobil Toyota. Metode analisis data yang digunakan dalam penelitian ini adalah metode analisis deskriptif dan analisis kuantitatif dengan alat analisis menggunakan EPIC model dan regresi linier berganda. Hasil analisis menggunakan EPIC model menunjukkan bahwa periklanan mobil Toyota berada pada rentang skala efektif dan uji statistik menunjukkan bahwa secara simultan indikator-indikator efektivitas periklanan yaitu pesan iklan (X1), pengenalan merek (X2), kepercayaan konsumen (X3), dan sikap konsumen (X4) berpengaruh signifikan terhadap keputusan pembelian (Y) pada F rasio sebesar 39.326 dengan tingkat signifikansi F< 0.05, selanjutnya secara parsial indikator-indikator efektifitas periklanan berpengaruh signifikan terhadap keputusan pembelian mobil Toyota. Adapun sikap konsumen (X4) berpengaruh negarif, namun signifikan terhadap keputusan pembelian mobil Toyota.
ANALISIS PREDIKSI KEBANGKRUTAN BANK SWASTA NASIONAL YANG TERDAFTAR DI BEI (Periode Tahun 2015 – 2019)
Authors: Khayatun Siti , Ambarwati Yunita Try
Published: January 2024

Penelitian ini membahas mengenai kebangkrutan perbankan pada Bank Swasta Nasional Devisa yang terdaftar pada Bursa Efek Indonesia (BEI). Penelitian ini dilatarbelakangi oleh banyaknya masyarakat yang menggunakan jasa perbankan sebagai alat pembayaran. Untuk itu bank harus selalu dalam keadaan sehat agar mampu menjalankan fungsinya dengan baik dan terhindar dari kebangkrutan. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Jumlah populasi sebanyak 44 bank yang terdaftar di BEI tahun 2015 – 2017. Sampel yang diambil sebanyak 17 bank swasta nasional devisa. Variabel dependen dalam penelitian ini adalah kesehatan bank. Sedangkan variabel independent yang digunakan dalam penelitian ini adalah CAR, NPL, ROE, ROA, LDR, dan BOPO. Metode pengumpulan data menggunakan metode sekunder. Metode analisis data yang digunakan dalam penelitian ini adalah Regresi Linear Berganda dengan menggunakan software SPSS 23. Hasil menunjukkan variabel CAR tidak berpengaruh signifikan terhadap kebangkrutan bank dengan nilai signifikan 0,079. Variabel NPL berpengaruh terhadap kebangkrutan bank dengan nilai signifikan 0,019. Varianel ROE tidak berpengaruh secara signifikan terhadap kebangkrutan bank dengan nilai signifikan 0,644. Variabel ROA berpengaruh terhadap kebangkrutan bank dengan nilai signifikan 0,019. Varianel LDR tidak berpengaruh secara signifikan terhadap kebangkrutan bank dengan nilai signifikan 0,580. Variabel BOPO berpengaruh terhadap kebangkrutan bank dengan nilai signifikan 0,037
MANAJEMEN PENGELOLAAN MEDIA PROMOSI AGROWISATA PERSEMAIAN PERMANEN GARAHAN (PPG) CLUSTER DURIAN WISATA PINUS SIDOMULYO KABUPATEN JEMBER
Authors: Lokaprasidha Pramesi , Magfira Mirza
Published: January 2024

The management of promotional media is a determining and supporting factor for tourism development.  This  study aimed  to  analyze  how  tourism  managers  use  and  maximize  promotional  media  in  managing  tourist  destinations  in  a  tourism  object  known  as Agrowisata  Persemaian Permanen  Garahan  Cluster  Durian  Wisata  Pinus  Sidomulyo  in  Jember and what impact this has on the number of tourist visits. This study used qualitative methods by conducting interviews and direct observation, tracing all documentation and literature related to promotional media management. The results of this study showed that the management of promotional media through social media, brochures, and pamphlets effectively increase  the number  of  tourist  visits  to  Agrowisata  Persemaian  Permanen Garahan Cluster Durian Wisata Pinus Sidomulyo in Jember.
MODEL STRATEGI PENINGKATAN DAYA SAING PRODUK BERBASIS EKONOMI KERAKYATAN DAN PANCASILA PADA UMKM TEH KELOR
Authors: Karim Kasnaeny , Yunus Sattar , Tajibu Muhammad Jibril
Published: January 2024

The People's economics at this time needs to be developed to increase community participation in the economic sector. For this reason, guidance is needed that comes from the state philosophy, namely Pancasila. The study aims to determine how to increase product competitiveness based on people's economics and Pancasila in Moringa Tea MSMEs in Makassar. The SWOT analysis method is used to formulate a strategy model for increasing product competitiveness by first identifying factors that can increase competitiveness by analyzing strengths and weaknesses. The research results show that the strategy model that can be implemented to increase the competitiveness of Moringa Tea MSME products based on people's economics and Pancasila is the SO model, namely the combination of strengths and opportunities through (1) Strengthening product distribution, (2) Implementing digital/online marketing, (3) Collaborating with parties who play a role in product development and marketing, (4) Implementing promotions conventionally or based on Information Technology, (5)Expanding innovations in packaging, (6) Innovating products that have more added value, (7) Improving MSME human resource capabilities, (8) Completing other permits and certifications, and (9) Improving the taste of Moringa tea.
PERAN CITRA MEREK SEBAGAI MEDIASI PENGARUH CELEBRITY ENDORSER DAN VIRAL MARKETING TERHADAP MOTIVASI KEPUTUSAN PEMBELIAN OREO X BLACKPINK
Authors: Rahmawati Yessica Gustya , Suryaningsih Ika Barokah , Musmedi Didik Pudjo
Published: January 2024

This research aims to examine the role of brand image as a mediator variable in the influence of celebrity endorser and viral marketing on decision motivation to purchase Oreo X Blackpink. This research was designed using explanatory research. Respondents were Blackpink fans who use social media Twitter in Indonesia. The sample used was 112 respondents with purposive sampling as the sampling method. Path analysis is a data analysis method that was used in this research. The results showed that: (1) Celebrity endorser has a significant and positive effect on brand image; (2) Viral marketing has a significant and positive effect on brand image; (3) Celebrity endorser has a significant and positive effect on purchase decision motivation; (4) Viral marketing has a significant and positive effect on purchase decision motivation; (5) Brand image has a significant and positive effect on purchase decision motivation; (6) Celebrity endorser has a significant and positive effect on purchase decision motivation through brand image; (7) Viral marketing has a significant and positive effect on purchase decision motivation through brand image.
PENGARUH LOYALITAS MEREK, PENGALAMAN PENGGUNA DAN PROMOSI PENJUALAN TERHADAP KEPUTUSAN PEMBELIAN PREMIUM CURRENCY PADA PERMAINAN ONLINE BERBASIS MOBILE
Authors: Putra I Gede Wisnu Satria Chandra , Natalia Desy
Published: January 2024

This research was conducted to analyze the factors that influence purchasing decisions for premium currency in mobile-based online games that are currently popular in Indonesia. In this case the author makes the online game Mobile Legends and Genshin Impact the object of research. This research was conducted using statistical testing methods on data from questionnaires that were successfully collected from 109 respondents. As a result, brand loyalty, user experience and sales promotions all have a significant positive effect on the purchase decision of premium currency in mobile-based online games either simultaneously or partially. Brand loyalty has the most significant influence compared to other variables due to the strong loyalty of Mobile Legends and Genshin Impact players. While sales promotion chooses the lowest effect due to the lack of promotion from both publishers and influencers.
THE DEVELOPMENT OF NURSING CARE MODEL IN PATIENTS WITH TOTAL KNEE REPLACEMENT RECONSTRUCTIVE SURGERY
Authors:   Registered Nurse, Senior Professional Level, Operation Theater, Loei Hospital, Thailand, Santisathaporn Rattiya , Chokpiriyawat Thanuset ,   Ph.D. Student, Faculty of Business Administration and Accountancy, Khonkaen University, Thailand
Published: January 2024

This research aims to develop a nursing care model for patients undergoing total knee replacement surgery (TKR) using the models Kemmis and McTaggart (1988) as development guidelines. The study has started from April to July 2020 in Operation Department, Loei hospital, Thailand. The purposive sampling method has been selected with participant nurses (n=50). The mixed method design has been used to obtain the new development nursing care model and guidelines for patient care, proper assignment system, and follow-up techniques. The result showed the nurse behavior changed before to after implementing a model in pre-operation, intra-operating, and post-operation stages statistically different at p less than .001 (mean = 4.9 ± 0.1, p<0.001, mean = 1.9 ± 0.1, p<0.001, mean = 2.0 ± 0.0, p<0.001) respectively. The nurse’s satisfaction level after cycle 2 was significantly higher than cycle 1 (mean = 4.2 ± 0.3, p<0.001). The development of the new nursing care model in TKR surgery could lead to changes in the system with gained positive feedback from OR nurses. The nursing leadership, group motivation, and a cooperative nursing team contributed to the successful operation of the new model. This research recommended following this model’s protocols as a routine and further expanding to other departments such as outpatient, inpatient, and continuous care units.
Editorial
Authors: Rossi Michele Marta , Neves Letícia de Oliveira , Silva Arthur Santos , Bernardini Sidney Piochi , Silva Vanessa Gomes da , Ruschel Regina Coeli , Melo Reymard Savio Sampaio de , Frajndlich Rafael Urano
Published: January 2024

O Volume 14 do periódico PARC Pesquisa em Arquitetura e Construção apresenta resultados de pesquisas nas seções de Artigos e Artigos de Revisão, abrangendo as temáticas de adequação ambiental, projeto de arquitetura e urbanismo, tecnologia de arquitetura e urbanismo, construção civil e história da arquitetura e urbanismo.  Neste volume difundimos a ciência em Arquitetura e Construção resultado de estudos de todo território nacional.  Neste rico universo representativo da ciência brasileira desejamos a todos uma excelente leitura e reflexões frutíferas.
A needs analysis on the utilization of learning management systems as blended learning media in elementary school
Authors: Zainil Melva , Helsa Yullys , Sutarsih Cicih , Nisa Sahrun , Sartono  , Suparman
Published: January 2024

In Indonesia, educational activities have shifted to home-based learning after the COVID-19 epidemic broke out.  Consequently, digital learning has become a necessary option for many teachers. This study aims to understand teachers’ experiences, digital platform mastery, digital-based learning pedagogy and the role of parents in learning at home in implementing the teaching process using learning management system-based blended learning media during the   COVID-19 epidemic. A questionnaire was used in this study to gather data on the experiences of the teachers, parents' participation in home learning during COVID-19, the digital pedagogy and the mastery of digital platforms using a qualitative approach.  This study involved 16 students’ parents and 96 elementary school teachers. The data was analyzed using NVivo Pro software. The testing of data validity was carried out through data triangulation. Results of this recent study revealed that based on their experience, teachers still used videos as the main teaching material in digital learning and they carried out the learning assessment process using digital platforms. This was impacted by the process of changing from distant learning to the new normal. Additionally, the selection of digital media was carried out by considering media effectiveness, the learning process, available facilities and digital literacy. Moreover, parents not only provided learning facilities at home but were also more active as facilitators and supervisors during the learning process at home. This study contributes to provide some considerations for mathematics teachers in designing learning management system-based blended learning media in elementary schools during the COVID-19 epidemic.
The Book by J. P. Eberhard on Applied Mathematics from the Book Collection of Kolyvan-Voskresensk Mining Plants
Authors: Ilyushechkina T. N.
Published: January 2024

The purpose of the article is to consider the book by J. P. Eberhard (Johann Peter Eberhard, 1727– 1779) “Beiträge zur Mathesi Applicata...” (1757) in the context of the reconstruction of the composition of the foreign part of the book collection of Kolyvan Voznesensk mining plants. The edition is a collection of articles on applied mathematics, devoted to the issues of mechanics, optics and gnomonics and intended, according to Eberhard,

“for students attending his lectures, for other teachers to prepare and conduct classes, and for those who want to help themselves in the study of applied mathematics”. The article defines the affiliation of the book to the library collections of the Kolyvan Voznesensk mining plants on the basis of service marks, reflecting the earliest stages of the use of the copy as a part of the Altai state libraries collections, attention is paid to thepersonality of the German author, whose works undoubtedly were a part of the scientific and technical thought of Europe in the second half of the XVIII century, the content of the articles composing the book and their compliance with the tasks of the Altai mining industry are revealed. The work “Beiträge zur Mathesi Applicata...” is considered in the context of other works, the continuation of which, according to the author's definition, it is and which, according to our assessment, are also presented in the book collection of the Kolyvan-Voskresensk mining plants. The results of the study expand the idea of the scale of J. P. Eberhard's personality and the relevance of his work for professional mining education and ensuring the production process in the Altai Mining District in the XVIII century, also add to the history of creation of the first in Siberia scientific technical library collection.
Literary and Publishing Activities of Poetic Groups of the Russian Far Eastern First-Wave Émigré
Authors: Makarova E. A.
Published: January 2024

The material laid down in the basis of the article is drawn on various bibliographic sources and library collections (Russian State Library, Russian National Library, Research Library of Tomsk State University). The object of the article is for the first time to present and systematize the main body of literary and fiction texts of the 1920s–1940s in the context of publishing activity of literary groups and associations of the Russian Far Eastern First-Wave émigré. The poetic activity of this period initially realized itself through groups, following the Silver Age traditions, and creative persons brought together, as fate willed it, in the situation of “Russian scattering.” In this aspect, the literary group is considered as a sociocultural form due to the methodology of Yu. N. Tynyanov, B. M. Eikhenbaum and A. I. Reitblat. Such tendencies were most apparent in the second period of the literary process formation among the Russian Far Eastern émigré in Harbin, where “Young Churaevka” literary association (1926–1935) had a very well-thoughtout program and concept. In addition to regular general gatherings and discussions among like-minded people, the typology of the literary group includes public speaking and promotion of joint undertakings in the press. As a rule, the activity of any literary group or association is directly connected with some publishing body, so the defining genre of such creativity is a literary collection – the most flexible type of literary publication with all kinds and genres of fiction. All this outlines the perspective for systematization of collections of that type and revealing their common typology with the determining role of socio-cultural environment.
Popularization of Books from the Scientific and Technical Library Collections: Holding Intellectual Games and Book Illustrative Exhibitions
Authors: Khromtsova A. E.
Published: January 2024

The Central Scientific and Technical Library for Construction and Architecture (CSTL C&A) in Moscow is the leading library of the Russian Federation in these areas. The library stock contains more than 1 million items of specialized literature, including foreign books and periodicals, and its readers are scholars and researchers from construction and architectural organizations, professors from the higher education institutions, as well as students of specialized colleges and institutes. Starting from 2022, the library has been actively engaged in cultural and educational activities, introducing new formats of events and developing interaction with audiences of different age groups, attracting more and more students from specialized colleges and universities.

The purpose of the article is to present the experience of CSTL C&A in popularizing books from its collections by means of holding intellectual games and book illustrative exhibitions. The prerequisites for the introduction of a new format of educational activities into the cultural activities of the institution are considered, the course of the game is described and nuances of its preparation are analyzed.

The e xperience presented by the author at the XXVII Annual Conference of the Russian Library Association “Library – the cultural code of Russia” can be useful for libraries with collections of limited usage, since it provides visitors with the opportunity to familiarize themselves with literature during the event.
Manifesto for transparent mathematical modeling: from ecology to general science
Authors: Kalmykov Vyacheslav L. , Kalmykov Lev V.
Published: January 2024

Mathematical black-box models, which hide the structure and behavior of the subsystems, currently dominate science. Mechanisms under study remain hidden. Errors and paradoxes, such as the biodiversity paradox and the limiting similarity hypothesis, often arise from subjective interpretations of these hidden mechanisms. To address these problems in ecology, we have developed transparent mathematical models of the white-box type. Here we present and justify the hypothesis that it is possible to construct transparent mathematical white-box models using logical deterministic cellular automata, where the rules used to construct these models are based on the general theory of the relevant domain. So far, white-box modeling has allowed us to directly identify the mechanisms of interspecific competition, test the principle of competitive exclusion and the hypothesis of limiting similarity, resolve the paradox of biodiversity, and formulate for the first time the general principle of competitive coexistence. As a framework for reproducing and further developing the method, we present a C++ code of two transparent mathematical models of an ecosystem. A shift to transparency in the mathematical modeling paradigm has the potential to revolutionize scientific research and to advance knowledge and technology in a wide variety of domains.
Pilocarpine-Induced Status Epilepticus in the Rat Hippocampus Is Associated with Reactive Glia and Concomitant Increased Expression of CD31, PDGFRβ and Collagen IV in Endothelial Cells and Pericytes of the Blood-Brain Barrier
Authors: Kyriatzis Grigorios , Bernard Anne , Bole Angélique , KHRESTCHATISKY Michel , FERHAT Lotfi
Published: January 2024

Temporal lobe epilepsy (TLE) is associated with reorganization of hippocampal neuronal net-works, gliosis, neuroinflammation, loss of integrity of the blood-brain barrier (BBB) in humans and animal models. More than 30% of epilepsies remain intractable and characterization of the molecular mechanisms involved in BBB dysfunction is essential to the identification of new thera-peutic strategies. In this work, we induced status epilepticus in rats by injection of the proconvul-sant drug pilocarpine that leads to TLE. Using RT-qPCR, double immunohistochemistry and con-focal imaging, we studied at different time points of epileptogenesis (latent phase, 3, 7, 14 days; chronic phase, 1 and 3 months) the regulation of reactive glia and vascular markers. In the hippo-campus, increased expression of mRNA encoding the glial proteins GFAP and Iba1 confirmed neu-roinflammatory status. We report for the first time the concomitant induction in endothelial cells, pericytes and basement membrane of the BBB of specific proteins CD31, PDGFR and ColIV, that peaks at the same time points as inflammation. The altered expression of these proteins occurs ear-ly in TLE, during the latent phase, suggesting that they could be associated with early rupture and pathogenicity of the BBB that will contribute to the chronic phase of epilepsy.
DNA Interactions and Biological Activity of 2,9-Disubstituted 1,10-Phenanthroline Thiosemicarbazone-Based Ligands and a 4-Phenylthiazole Derivative
Authors: Nicolás Álvaro , Quero Julia G. , Barroso Marta , Gándara Zoila , Gude Lourdes
Published: January 2024

Four 1,10-phenanthroline derivatives (1-4) have been synthesized as potential telomeric DNA binders, three substituted in their chains with thiosemicarbazones (TSCs), the neutral compound (1) and two ionic derivatives (PF6¯ and BF4¯ salts, 2 and 3, respectively), and a fourth corresponding to a 4-phenylthiazole derivative (4). Quadruplex and dsDNA interactions have been preliminarily studied, especially for the neutral derivative 1, by FRET-based DNA melting assays, equilibrium dialysis (both competitive and non-competitive), circular dichroism and viscosity titrations. The TSC derivatives bind and stabilize the telomeric Tel22 quadruplex more efficiently than dsDNA, with an estimated 24-fold selectivity determined by equilibrium dialysis for compound 1. In addition, cytotoxic activity against different tumor cells (PC-3, DU145, HeLa, MCF-7 and HT29), and two non-tumor cell lines (HFF-1 and RWPE-1) has been evaluated. Except for the 4-phenylthiazole derivative, which was inactive, the compounds show moderate cytotoxic properties, with the salts displaying lower IC50 values, compared to the neutral TSC. However, the neutral derivative was the only compound that exhibited a modest selectivity in the case of prostate cells (tumor PC-3 versus healthy RWPE-1). Cell cycle analysis and Annexin V/PI assays revealed that the compounds can produce cell death by apoptosis, an effect that has proven similar to that demonstrated by other known 1,10-phenanthroline G4 ligands endowed with antitumor properties, such as PhenDC3 or PhenQE8.
Primary Bone Lymphoma of the Scapula with an Unexpected Complication
Authors: Lovaković Josip , Mandac Smoljanović Inga , Matković Andro , Smoljanović Tomislav
Published: January 2024

Primary bone lymphoma of the scapula is a rare tumor that usually causes local pain. Presented patient suffered for two years from paresthesia, tingling, numbness, and edema of the little and ring finger. The 45-year-old man underwent several radiological and neurological assessments of the palm, elbow and neck prior to radiographs revealing the tumor of the left shoulder. Once diffuse large B cell lymphoma was confirmed, immunochemotherapy with rituximab, cyclophosphamide, doxorubicin, vincristine, and methylprednisolone (R-CHOP) started. The treatment was accompanied by antiviral treatment with lamivudine due to positive hepatitis B virus serology and with bisphosphonate treatment for the prevention of bone resorption. Once immunochemotherapy was finished, the treatment was supplemented by radiotherapy of the shoulder. After more than three years of accomplishing remission, the patient had an ischemic stroke manifesting with right-sided hemiparesis. Following the physical therapy, the patient is currently in the process of evaluation for thrombophilia, as well as further cardiac assessment due to the positive transcranial Doppler bubble test setting high suspicion for the presence of patent foramen ovale.
Temporal and Spatial Analyses of Forest Burnt Area in the Middle Volga Region Based on the Satellite Imagery and Climatic Factors
Authors: Kurbanov Eldar , Vorobev Oleg , Lezhnin Sergey , Dergunov Denis , Wang Jinliang , Sha Jinming , Gubaev Aleksandr , Tarasova Ludmila , Wang Yibo
Published: January 2024

Wildfires are important natural drivers of forest stands dynamics, strongly influencing on their natural regeneration and ecosystem services. This paper presents a comprehensive analysis of spatiotemporal burnt area (BA) patterns over the period 2000–2022 in the Middle Volga region of the Russian Federation on the base of remote sensing time series, considering the impact of cli-matic factors on forest fires. The temporal trends were assessed with the Mann-Kendall nonpara-metric statistical test and Theil-Sen’s slope estimator using the LandTrendr algorithm on the Google Earth Platform (GEE). The accuracy assessment indicated a high overall accuracy (> 84%) and F-score value (> 82%) for forest burnt area detection as evaluated against 581 test sites of ref-erence data. The results revealed that the fire occurrences in the region were mainly irregular with the highest frequency of 7.3 over a 22-year period. The total forest BA was about 280 thousand ha, which equals to 1.7% of the land surface area or 4.0% of the total forested area under study in the Middle Volga region. The coniferous forest stands are the most fire-prone ecosystems accounting for 59.0 % of the total BA; deciduous stands accounts for 25.1%; and insignificant fire occurrences were registered in young forests and shrub lands. On a seasonal scale, temperature generally has a greater impact on the BA than precipitation and wind speed.
Analysis of Blade Aspect Ratio Influence on High-Speed Axial Compressor Performance
Authors: Silva Lucilene Moraes da , Grönstedt Tomas , Xisto Carlos , Whitacker Luiz Henrique Lindquist , Bringhenti Cleverson , Lejon Marcus
Published: January 2024

The ratio between blade height and chord, named aspect ratio (AR), plays an important role in compressor aerodynamic design. Once selected, it influences stage performance, blade losses, and the stage stability margin. The choice of the design AR involves both aerodynamic and mechanical considerations, and a reasonable aim is frequently to achieve a desired operating range while maximizing efficiency. For a fixed set of aerodynamic and geometric parameters there will be an optimal choice in AR that achieves a maximum efficiency. However, for a state-of-the-art aero-engine design optimality means multi-objective optimality, that is reaching the highest possible efficiency for a number of operating points while achieving a sufficient stability margin. To this end, the influence of the AR on the performance of the first rotor row of a multistage multi-objective high-speed compressor design is analyzed. A careful setup of the high-speed aerodynamic design problem allows the effect of the AR to be isolated. Close to the optimal AR, only a modest efficiency variation is observed, but a considerable change in compressor stability margin (SM) is noted. Decreasing the AR allows for an increasing efficiency, but at the expense of a reduced surge margin. This allows the designer to trade efficiency for stability. Increasing the AR, however, is shown to reduce both surge margin and efficiency, hence a distinct optimality in stability is observed for the analyzed rotor blade row. In this work, the optimality in surge margin with respect to AR is observed whereas a close to optimal efficiency. The predicted range from AR=1.10 to AR=1.64, is only indicative, considering that the definition of a multi-objective optimality requires balancing efficiency and surge margin and that the choice of balancing these two criteria requires making a design choice along a pareto optimal front.
Ensuring Financial Wellness in Healthcare: Unveiling Challenges and Seizing Opportunities in Hospital Management Accounting for Sustainable Success
Authors: Almeida Marques Paula Cristina , Oliveira Paulo Alexandre , Barbosa Sofia Nair
Published: January 2024

The efficient and sustainable management of hospitals is an increasingly relevant challenge in the healthcare sector. With limited financial resources, regulatory pressures and increasing demands for quality services, hospitals are faced with the want to approve sound policies to certify financial and operational sustainability. Management accounting is critical in this instance. In Portugal the DL nº 284, of July 26, 1999, allow us to confirm the need to reinforcement of profitability and efficiency in the provision of healthcare.
Management accounting is an essential tool for monitoring and controlling costs, making strategic decisions, efficiently allocating resources and evaluating performance in the hospital environment. It allows a comprehensive view of financial and operational aspects, providing valuable information for management and strategic planning.
However, the sustainability of hospital management accounting is a critical and complex topic that deserves special attention. Hospitals face several challenges, such as the complexity of hospital costs, the integration of information systems and the measurement of healthcare value. These challenges can compromise the effectiveness of management accounting and its ability to provide relevant and reliable information for decision making.
As a result, it is required to address the sustainability of hospital management accounting by identifying the specific challenges faced in this area and exploring opportunities to overcome them. By addressing these challenges and seizing opportunities, hospitals can strengthen their position in the healthcare sector, improve their operational efficiency, optimize resource allocation and ensure the provision of quality services to patients.
In this article, the challenges faced by hospital management accounting will be analysed, such as the complexity of costs, the integration of information systems and the measurement of value in healthcare. Additionally, opportunities to improve financial and operational management will be highlighted through the adoption of advanced technologies, an emphasis on value-based management and collaborative partnerships. By exploring these themes, this essay aims to make a contribution. to the advancement of hospital management accounting and the sustainability of hospitals in the current healthcare scenario.
NF-κB: Governing Innate Immunity in Cancer
Authors: Cornice Jessica , Verzella Daniela , Arboretto Paola , Vecchiotti Davide , Capece Daria , Zazzeroni Francesca , Franzoso Guido
Published: January 2024

Tumor-associated macrophages (TAMs) are the major component of the tumor microenvironment (TME), where they sustain tumour progression and anti-tumor immunity. Due to their plasticity, macrophages can exhibit anti- or pro-tumor functions through the expression of different gene sets leading to distinct macrophages phenotypes: M1-like or pro-inflammatory and M2-like or anti-inflammatory. NF-κB transcription factors are central regulators of TAMs in cancers, where they often drive macrophage polarization towards M2-like phenotype. Therefore, the NF-κB pathway is an attractive therapeutic target for cancer immunotherapy in a wide range of human cancers. Hence, targeting NF-κB pathways in the myeloid compartment is a potential clinically strategy to overcome microenvironment-induced immunosuppression and increase anti-tumor immunity. In this review, we discuss the role of NF-κB as key driver of macrophage functions in tumours as well as the principal strategies to overcome tumour immunosuppression by targeting NF-κB pathway.
Enhancements of Wave Power Absorption with Arrays and a Vertical Breakwater
Authors: Kara Fuat
Published: January 2024

The capability of in-house transient wave-multibody computational tool of ITU-WAVE are extended to predict the wave power absorption with Wave Energy Converters (WECs) arrays placed in front of a vertical breakwater. The analyses of hydrodynamic exciting and radiation forces are approximated solving boundary integral equation at each time interval. The reflection of incoming waves due to a vertical wall is predicted with method of images. The constructive or destructive performance of WECs arrays with different array configurations is measured with mean interaction factor. The behaviour of the exciting and radiation hydrodynamic forces of each WEC due to a vertical wall effect shows considerable differences than those of WECs arrays without a vertical wall influence. When the wave power absorption with WECs arrays with and without a vertical wall effect are compared, it is shown with numerical experiences that WECs placed in front of a vertical wall have much greater effects on wave power absorption. This can be attribute to the hydrodynamic interaction, standing waves, and nearly trapped waves in the gap between a vertical wall and WECs arrays. The analytical and other numerical results are used to for the validation of the numerical results of the present ITU-WAVE computational tool for exciting and radiation forces, and mean interaction factor of WECs arrays which show satisfactory agreements.
Stress Control in Elderly through Healing Garden Activities
Authors: Kim Sun-Hee , Ryu Byung-Yeol , Seo Joo-Bong
Published: January 2024

This study was conducted on elderly over 65 years of age to verify that healing garden activities control stress in the elderly. The experimental group performed garden activities once a week for 12 weeks, 2 hours each, and the control group continued their daily lives. Each group's cumulative stress at the beginning and end, total power (TP), the standard deviation of the normal-to-normal interval (SDNN), and root mean square differences of successive R-R intervals (RMSSD) were measured using a stress index meter, u-bio MACPA. As a result of the analysis, the experimental group had a statistically significant decrease in cumulative stress compared to the control group, and TP significantly increased compared to the control group. SDNN and RMSSD of the experimental group increased, respectively, and the control group decreased, respectively, but it was not statistically significant. The fact that cumulative stress decreased, and stress evaluation indicators increased shows that daily stress can be controlled through healing garden activities. This confirms that the value of the garden can extend to healing.
Jump Rope Exercise Improves Executive Function in Children with Attention-Deficit/Hyperactivity Disorder
Authors: Li Liang , Huang Zi-Yun , Lu Yi-Juan , Wu Xue-ping
Published: January 2024

Objective: This study investigated the effects of an easily implemented 8-week program centered around jump rope exercise (JRE) on executive function among children with ADHD. Methods: Using the Stroop Color Word Test to assess inhibitory control, the n-back task (1- and 2-back) to assess working memory, and task switching to assess cognitive flexibility. Results: After the intervention, there were within-group effects only for the experimental group, with higher accuracy on the 1-back working memory task (t= -2.79，p= 0.011< 0.05，Cohen’s d= 0.60) and on task switching after compared with before the JRE intervention (t= -4.00，p=0.01<0.05，Cohen’s d= 0.85), but with no change in reaction time. There was no significant within-group difference on the Stroop test (P> 0.05). Additionally, there were no between-group effects as assessed by one-way analyses of variance. Conclusion: 8-week program focused on JRE improved two aspects of executive function, working memory and cognitive flexibility, with no significant effect on a third aspect, inhibitory control, among children with ADHD aged 7 to 12 years.
Vascular Diseases In Women. Do women suffer from them differently?
Authors: Farkas Katalin , Stanek Agata , Zbinden Stephanie , Borea Barbara , Ciurica Simina , Moore Vanessa , Maguire Peggy , Abola Maria Teresa B. , Alajar Elaine B , Marcoccia Antonella , Erer Dilek , Casanegra Ana I. , Sharebiani Hiva , Sprynger Muriel , Kavousi Maryam , Catalano Mariella
Published: January 2024

According to the World Health Organization, cardiovascular disease (CVD) is the leading cause of death among women worldwide, yet its magnitude is often underestimated. Biological and gender differences affect health, diagnosis, and healthcare in numerous ways. The lack of sex and gender awareness in health research and healthcare is an ongoing issue and affects not only research, but also treatment and outcomes. The importance of recognising the impact of both sex and gender on health and of knowing the differences between the two in healthcare is beginning to gain ground. There is more appreciation of the role that biological differences (sex) and sociocultural power structures (gender) have, and both sex and gender affect health behaviour, the development of diseases, their diagnosis, management, and long-term effects of an illness. An important issue is the knowledge and awareness of women about vascular diseases. The risk of cardiovascular events is drastically underestimated by women themselves, as well as by those around them. The purpose of this review is to draw attention to improving the medical care and treatment of women with vascular diseases.
Active Distribution Grid Exceeding Testing and Risk Planning Based on Carbon Capture and Multi-Source Data of Power Internet of Things
Authors: Wu Jinghan , Wang Kun , Wang Tianhao , Ma Shiqian , Gong Hansen , Hu Zhijian , Gong Qingwu
Published: January 2024

In order to achieve its carbon peak and neutrality targets, a high proportion of distributed power sources are connected to the distribution network in China, which greatly increases the risk of distribution network operation. Aiming at the above problems, this paper proposes an active distribution network risk planning model based on multi-source data from carbon capture and power internet of things, and conducts exceeding testing of distribution network based on the stochastic load flow algorithm with semi-invariant and level expansion, calculates the semi-invariant of each order of node state vectors and branch current vectors, and then utilizes the Gram-Charlier level expansion to obtain the exceeding probability density function and probability distribution function of the node voltages and line powers of the distribution network. The probability density function and probability distribution function of the exceeding are obtained using the Gram-Charlier series expansion. Combined with multi-source data, the active distribution network with integrated energy system considering carbon capture is modeled. According to the risk scenario of the distribution network, the nonconvex constraints in the model are simplified by the second-order cone relaxation, and the optimal planning scheme of the distribution network is solved by combining the gurobi solver with the risk index as the first-level objective and the economic benefit as the second-level objective. The simulation results of a coupled network consisting of a 39-node distribution network and an 11-node transportation network verify the effectiveness of the proposed model.