bluuebunny/crossref_metadata_2025 huggingface dataset:
Linking gender differences with gender equality: A systematic-narrative literature review of basic skills and personality
Authors: Balducci Marco
Published: February 2023

There is controversy regarding whether gender differences are smaller or larger in societies that promote gender equality highlighting the need for an integrated analysis. This review examines literature correlating, on a national level, gender differences in basic skills—mathematics, science (including attitudes and anxiety), and reading—as well as personality, to gender equality indicators. The aim is to assess the cross-national pattern of these differences when linked to measures of gender equality and explore new explanatory variables that can shed light on this linkage. The review was based on quantitative research relating country-level measures of gender differences to gender equality composite indices and specific indicators. The findings show that the mathematics gender gap from the PISA and TIMMS assessments, is not linked to composite indices and specific indicators, but gender differences are larger in gender-equal countries for reading, mathematics attitudes, and personality (Big Five, HEXACO, Basic Human Values, and Vocational Interests). Research on science and overall scores (mathematics, science, and reading considered together) is inconclusive. It is proposed that the paradox in reading results from the interrelation between basic skills and the attempt to increase girls’ mathematics abilities both acting simultaneously while the paradox in mathematics attitudes might be explained by girls being less exposed to mathematics than boys. On the other hand, a more nuanced understanding of the gender equality paradox in personality is advanced, in which a gene–environment-cultural interplay accounts for the phenomenon. Challenges for future cross-national research are discussed.
Investigating students’ attitudes towards translation technology: The status quo and structural relations with translation mindsets and future work self
Authors: Tian Sha , Jia Lingxiao , Zhang Zhining
Published: February 2023

Introduction

Despite the growing attention paid to the research of translation technology teaching (TTT), there is still a lack of studies on students’ attitudes and the motivational factors in relation to it. To this end, the paper reports on a questionnaire-based study that describes students’ attitudes towards translation technology (in the Chinese MTI context) and explores its structural relations with translation mindsets and future work self.

Methods

Data were collected from 108 grade 2021 MTI students of three selected Chinese universities and analyzed using descriptive statistics and structural equation modeling (SEM).

Results

The results demonstrate that Chinese MTI students’ overall attitudes towards translation technology are slightly positive. So far, they perceive translation technology to be slightly effective for translation and are slightly mindful of it. They are slightly influenced by teachers and still feel inhibited when learning and using it. Furthermore, the results also indicate that growth translation mindsets positively influence students’ attitudes towards the effectiveness of translation technology, teacher influence, exhibition to translation technology, and mindfulness about translation technology, whereas fixed translation mindsets only negatively predict students’ teacher influence. Likewise, future work self-salience positively associates with students’ attitudes towards the effectiveness of translation technology and mindfulness about translation technology, while future work self-elaboration positively relates to students’ exhibition to translation technology. Among them, growth translation mindsets are the strongest predictor for all attitudes components.

Discussion

Theoretical and pedagogical implications are also discussed.
Part of speech tagging of grammatical features related to L2 Chinese development: A case analysis of Stanza in the L2 writing context
Authors: Lan Ge , Pan Xiaofei , Sun Yachao , Lu Yuan
Published: February 2023

Grammatical complexity has received extensive attention in second language acquisition. Although computational tools have been developed to analyze grammatical complexity, most relevant studies investigated this construct in the context of English as a second language. In response to an increasing number of L2 Chinese learners, it is important to extend the investigation of grammatical complexity in L2 Chinese. To promote relevant research, we evaluated the new computational tool,Stanza, on its accuracy of part-of-speech tagging for L2 Chinese writing. We particularly focused on eight grammatical features closely related to L2 Chinese development. Then, we reported the precisions, recalls, and F-scores for the individual grammatical features and offered a qualitative analysis of systematic tagging errors. In terms of the precision, three features have high rates, over 90% (i.e.,baandbeimarkers, classifiers, -deas noun modifier marker). For recall, four features have high rates, over 90% (i.e., aspect markers,baandbeimarkers, classifiers, -deas noun modifier marker). Overall, based on the F-scores, Stanza has a good tagging performance onbaandbeimarkers, classifiers, and -deas a noun modifier marker. This evaluation provides research implications for scholars who plan to use this computational tool to study L2 Chinese development in second language acquisition or applied linguistics in general.
Therapies for obsessive-compulsive disorder: Current state of the art and perspectives for approaching treatment-resistant patients
Authors: Swierkosz-Lenart Kevin , Dos Santos Joao Flores Alves , Elowe Julien , Clair Anne-Hélène , Bally Julien F. , Riquier Françoise , Bloch Jocelyne , Draganski Bogdan , Clerc Marie-Thérèse , Pozuelo Moyano Beatriz , von Gunten Armin , Mallet Luc
Published: February 2023

Even though obsessive compulsive disorder (OCD) is one of the ten most disabling diseases according to the WHO, only 30–40% of patients suffering from OCD seek specialized treatment. The currently available psychotherapeutic and pharmacological approaches, when properly applied, prove ineffective in about 10% of cases. The use of neuromodulation techniques, especially Deep Brain Stimulation, is highly promising for these clinical pictures and knowledge in this domain is constantly evolving. The aim of this paper is to provide a summary of the current knowledge about OCD treatment, while also discussing the more recent proposals for defining resistance.
Psychosocial factors associated with the risk of developing psychosis in a Mexican general population sample
Authors: Domínguez-Martínez Tecelli , Sheinbaum Tamara , Fresán Ana , Nieto Lourdes , López Steven R. , Robles Rebeca , Lara Ma del Carmen , de la Fuente-Sandoval Camilo , Barrantes-Vidal Neus , Saracco Ricardo , Franco-Paredes Karina , Díaz-Reséndiz Felipe , Rosel Mauricio
Published: February 2023

Epidemiological evidence has linked an array of sociodemographic and psychosocial factors with an increased risk of developing psychosis. However, research in samples from low- and middle-income countries is still scarce. This study used a Mexican sample to explore (i) sociodemographic and psychosocial differences between individuals with and without a positive screen for Clinical High-Risk for psychosis (CHR), and (ii) sociodemographic and psychosocial factors associated with screening positive for CHR. The sample consisted of 822 individuals from the general population who completed an online survey. Of the participants, 17.3% (n = 142) met the CHR screening criteria. Comparisons between those who screened positive (CHR-positive group) and those who did not (Non-CHR group) showed that participants in the CHR-positive group were younger, had a lower educational level, and reported more mental health problems than the Non-CHR group. Furthermore, relative to the Non-CHR group, the CHR-positive group had a greater prevalence of medium/high risk associated with cannabis use, a higher prevalence of adverse experiences (bullying, intimate partner violence, and experiencing a violent or unexpected death of a relative or friend), as well as higher levels of childhood maltreatment, poorer family functioning, and more distress associated with the COVID-19 pandemic. Groups did not differ in sex, marital/relationship status, occupation, and socio-economic status. Finally, when examined in multivariate analyses, the variables associated with screening positive for CHR were: having an unhealthy family functioning (OR = 2.75, 95%CI 1.69–4.46), a higher risk associated with cannabis use (OR = 2.75, 95%CI 1.63–4.64), a lower level of education (OR = 1.55, 95%CI 1.003–2.54), having experienced a major natural disaster (OR = 1.94, 95%CI 1.18–3.16), having experienced a violent or unexpected death of a relative or friend (OR = 1.85, 95%CI 1.22–2.81), higher levels of childhood emotional abuse (OR = 1.88, 95%CI 1.09–3.25), physical neglect (OR = 1.68, 95%CI 1.08–2.61), and physical abuse (OR = 1.66, 95%CI 1.05–2.61), and higher COVID-related distress (OR = 1.10, 95%CI 1.01–1.20). An older age was a protective factor for screening positive for CHR (OR = 0.96, 95%CI 0.92–0.99). Overall, the findings highlight the importance of examining potential psychosocial contributors to psychosis vulnerability across different sociocultural contexts to delineate risk and protective processes relevant to specific populations and better target preventive intervention efforts.
Acupuncture and moxibustion in patients with cancer-related insomnia: A systematic review and network meta-analysis
Authors: Ou Yangxu , Lin Dezhi , Ni Xixiu , Li Simeng , Wu Kexin , Yuan Lu , Rong Jing , Feng Chengzhi , Liu Junqian , Yu Yang , Wang Xiao , Wang Linjia , Tang Zili , Zhao Ling
Published: February 2023

Objectives

Cancer-related insomnia (CRI) is one of the most common and serious symptoms in patients with cancer. Acupuncture and moxibustion have been widely applied in the treatment of CRI. Nevertheless, the comparative efficacy and safety of different acupuncture and moxibustion techniques remain unclear. This study aimed to evaluate and compare the efficacy and safety of different acupuncture and moxibustion techniques in the treatment of CRI.

Methods

Eight medical databases were comprehensively searched for relevant randomized controlled trials (RCTs) as of June 2022. Two independent reviewers assessed the risk of bias and conducted the research selection, data extraction, and quality assessment of the included RCTs. A network meta-analysis (NMA) was performed using frequency models, combining all available direct and indirect evidence from RCTs. The Pittsburgh Sleep Quality Index (PSQI) was set as the primary outcome, and adverse events and effective rates were set as the secondary outcomes. The efficacy rate was calculated as the ratio of patients with insomnia symptom relief to the total number of patients.

Results

Thirty-one RCTs with 3,046 participants were included, including 16 acupuncture- and moxibustion-related therapies. Transcutaneous electrical acupoint stimulation [surface under the cumulative ranking curve (SUCRA) 85.7%] and acupuncture and moxibustion (SUCRA 79.1%) were more effective than Western medicine, routine care, and placebo-sham acupuncture. Furthermore, Western medicine showed significantly better effects than placebo-sham acupuncture. In the NMA, the acupuncture and moxibustion treatments with the best therapeutic effects for CRI were transcutaneous electrical acupoint stimulation (SUCRA 85.7%), acupuncture and moxibustion (SUCRA 79.1%), auricular acupuncture (SUCRA 62.9%), routine care combined with intradermal needling (SUCRA 55.0%), and intradermal needling alone (SUCRA 53.3%). No serious acupuncture- or moxibustion-related adverse events were reported in the included studies.

Conclusion

Acupuncture and moxibustion are effective and relatively safe in treating CRI. The relatively conservative recommended order of acupuncture- and moxibustion-related therapies for CRI is as follows: transcutaneous electrical acupoint stimulation, acupuncture and moxibustion, and auricular acupuncture. However, the methodological quality of the included studies was generally poor, and further high-quality RCTs are needed to strengthen the evidence base.
Association between anxiety and metabolic syndrome: An updated systematic review and meta-analysis
Authors: Ji Shuang , Chen Yujiao , Zhou Yuying , Cao Yiting , Li Xiao , Ding Guoyong , Tang Fang
Published: February 2023

Objective

Previous studies have demonstrated an association between anxiety and metabolic syndrome (MetS). However, the association is still controversial. This updated meta-analysis aimed to reanalyze the association between anxiety and MetS.

Methods

We comprehensively searched PubMed, Embase and Web of Science for all related studies published before January 23, 2023. Observational studies that informed effect size with 95% confidence interval (CI) for the association between anxiety and MetS were included. According to heterogeneity between studies, fixed or random effects models were applied to calculate the pooled effect size. Publication bias was examined by funnel plots.

Results

The research included 24 cross-sectional studies: 20 studies used MetS as the dependent variable with a pooled OR of 1.07 (95% CI: 1.01–1.13) and four studies used anxiety as the dependent variable with a pooled OR of 1.14 (95% CI: 1.07–1.23). Three cohort studies were found: two studies detected the association of baseline anxiety with the risk of MetS, one of the studies demonstrated a significant association, but a similar result was not found in another study; one study showed no significant association between baseline MetS and the risk of anxiety.

Conclusion

Cross-sectional studies indicated an association between anxiety and MetS. The results from cohort studies are still inconsistent and limited. More large-scale prospective studies are needed to further reveal the causal relationship of anxiety with MetS.
Effort-based decision making in schizotypy and its relationship with amotivation and psychosocial functioning
Authors: Chu Ryan Sai Ting , Tong Co Co Ho Yi , Wong Corine Sau Man , Chang Wing Chung , Tang Wesley Chor Yin , Chan Charlotte Cheuk Lok , Lui Simon S. Y. , Hui Lai Ming , Suen Yi Nam , Chan Kit Wa , Lee Ho Ming , Chen Eric Yu Hai
Published: February 2023

Introduction

Suboptimal effort-based decision-making with reduced willingness to expend effort for high-probability/high-value reward is observed in schizophrenia patients and is related to diminished motivation, but is understudied in schizotypy. This study aimed to examine effort-allocation in schizotypy individuals and its association with amotivation and psychosocial functioning.

Methods

We recruited 40 schizotypy individuals and 40 demographically-matched healthy controls, based on Schizotypal Personality Questionnaire-Brief (SPQ-B) score (top and bottom 10% SPQ-B scores, respectively), from 2400 young people aged 15-24 years participating a population-based mental health survey in Hong Kong and examined effort-allocation using the Effort Expenditure for Reward Task (EEfRT). Negative / amotivation symptoms and psychosocial functioning were assessed by the Brief Negative Symptom Scale (BNSS) and the Social Functioning and Occupational Assessment Scale (SOFAS), respectively. Schizotypy individuals were categorized into high-amotivation and low-amotivation groups based on a median-split of BNSS amotivation domain score.

Results

Our results showed no main group effect (in either two or three-group comparison) on effort task performance. Three-group comparison analyses on selected EEfRT performance indices revealed that high-amotivation schizotypy individuals displayed significantly less increase in effortful options from low-value to high-value reward (reward-difference score) and from low-probability/low-value to high-probability/high-value reward (probability/reward-difference score) than low-amotivation individuals and controls. Correlation analyses demonstrated trend-wise significance between BNSS amotivation domain score and several EEfRT performance indices in schizotypy group. Schizotypy individuals with poorer psychosocial functioning tended to exhibit smaller probability/reward-difference score relative to other two groups.

Discussion

Our findings indicate subtle effort-allocation abnormalities in schizotypy individuals with high levels of diminished motivation, and suggest the link between laboratory-based effort-cost measures and real-world functional outcome.
Secular trends in mental health profiles among 15-year-olds in Sweden between 2002 and 2018
Authors: Eriksson Charli , Stattin Håkan
Published: February 2023

Background

Studies of secular trends in mental unhealth indicate that adolescents in the Nordic countries, especially girls, have an increased reported prevalence of mental health problems the last decades. This increase needs to be seen in the light of the adolescents' assessments of their perceived overall health.

Objective

To investigate whether a person-centered approach to research can enhance understanding of changes over time in the distribution of mental health problems among Swedish adolescents.

Method

A dual-factor approach was used to study changes over time in mental health profiles among nationally representative 15-year-old adolescent samples from Sweden. Cluster analyses of subjective health symptoms (psychological and somatic) and perceived overall health from the Swedish Health Behavior in School-aged Children (HBSC) surveys of 2002, 2006, 2010, 2014, and 2018 were used to identify these mental health profiles (n = 9,007).

Results

Four mental health profiles were identified by a cluster analysis which combined all five data collections—Perceived good health, Perceived poor health, High psychosomatic symptoms, and Poor mental health. There were no significant differences in the distributions of these four mental health profiles between the survey years 2002 and 2010, but substantial changes took place between 2010 and 2018. Here, particularly the High psychosomatic symptoms profile increased among both boys and girls. The Perceived good health profile decreased among both boys and girls, and the Perceived poor health profile decreased among girls. The profile involving the most pronounced mental health problems, the Poor mental health profile (perceived poor health, high psychosomatic problems), was stable from 2002 to 2018 among both boys and girls.

Conclusion

The study shows the added value of using person-centered analyses to describe differences in mental health indicators between cohorts of adolescents over longer periods of time. In contrast to the long-term increase in mental health problems seen in many countries, this Swedish study did not find an increase among young persons, both boys and girls, with the poorest mental health, the Poor mental health profile. Rather, the most substantial increase over the survey years, predominantly between 2010 and 2018, was found among the 15-year-olds with High psychosomatic symptoms only.
Adapting the World Health Organization iSupport Dementia program to the Indonesian socio-cultural context
Authors: Turana Yuda , Kristian Kevin , Suswanti Ika , Sani Tara Puspitarini , Handajani Yvonne Suzy , Tran Kham , Nguyen Tuan Anh
Published: February 2023

Background

Providing care for people with dementia (PwD) without sufficient understanding of the condition might negatively affect the wellbeing of the caregivers, given the lengthy care and progressive nature of the disease. The iSupport for dementia developed by World Health Organization (WHO) is a self-administered training manual for caregivers of PwD, adaptable to local cultures and contexts. This manual needs translation and adaptation to produce a culturally appropriate version for use in Indonesia. This study reports the outcomes and lessons learnt from our translation and adaptation of iSupport content into Bahasa Indonesia.

Methods

The original iSupport content was translated and adapted using the WHO iSupport Adaptation and Implementation Guidelines. The process included forward translation, expert panel review, backward translation, and harmonization. The adaptation process included Focus Group Discussions (FGD), involving family caregivers, professional care workers, professional psychological health experts, and Alzheimer's Indonesia representatives. The respondents were asked to express their opinions about the WHO iSupport program, which comprises five modules and 23 lessons covering well-established topics on dementia. They were also asked to suggest improvements and their personal experiences compared to the adaptations applied in the iSupport.

Results

Two experts, 10 professional care workers, and eight family caregivers participated in the FGD. Overall, all participants had positive views of the iSupport material. The expert panel identified the need to reformulate definitions, recommendations, and local case studies to fine-tune the original contents to local knowledge and practices. Based on the feedback in the qualitative appraisal, several improvements regarding the language and diction, additional relevant and concrete examples, personal names and cultural habits, and customs and traditions were addressed.

Conclusions

The translation and adaptation of the iSupport into the Indonesian context have shown some changes needed to make the iSupport content culturally and linguistically appropriate for Indonesian end users. In addition, given the broad spectrum of dementia, various case illustrations have been added to improve the understanding of care in particular situations. Future studies are needed to evaluate the efficacy of the adapted iSupport in improving the quality of life of PwD and their caregivers.
Changes in social isolation and loneliness prevalence during the COVID-19 pandemic in Japan: The JACSIS 2020–2021 study
Authors: Murayama Hiroshi , Suda Takumi , Nakamoto Isuzu , Shinozaki Tomohiro , Tabuchi Takahiro
Published: February 2023

Objective

The recent coronavirus disease 2019 (COVID-19) outbreak has changed people's social connections with others and society. This study aimed to describe changes in the prevalence of social isolation and loneliness by demographic characteristics, socioeconomic status, health conditions, and outbreak situations in residential prefectures among Japanese people between the first year (2020) and the second year (2021) of the COVID-19 pandemic.

Methods

We used data from the Japan COVID-19 and Society Internet Survey (JACSIS) study, a large-scale web-based nationwide survey conducted with 53,657 participants aged 15–79 years in August–September 2020 and September–October 2021 (25,482 and 28,175 participants, respectively). Social isolation was defined as less than once a week in the total frequency of contact with family members or relatives who were living apart and friends/neighbors. Loneliness was assessed using the three-item University of California, Los Angeles (UCLA) Loneliness Scale (score range, 3–12). We used generalized estimating equations to estimate the prevalence of social isolation and loneliness in each year and the difference in prevalence between 2020 and 2021.

Results

The weighted proportion (95% confidence interval) of social isolation in the total sample was 27.4% (25.9, 28.9) in 2020 and 22.7% (21.9, 23.5) in 2021, representing a change of −4.7 percentage points (−6.3, −3.1). The weighted mean scores of the UCLA Loneliness Scale were 5.03 (4.86, 5.20) in 2020 and 5.86 (5.81, 5.91) in 2021, representing a change of 0.83 points (0.66, 1.00). The detailed trend changes for social isolation and loneliness were noted in the demographic subgroups of socioeconomic status, health conditions, and outbreak situation in the residential prefecture.

Conclusion

Social isolation decreased from the first to the second year of the COVID-19 pandemic, whereas loneliness increased. Assessing the COVID-19 pandemic's impact on social isolation and loneliness contributes to understanding who was particularly vulnerable during the pandemic.
Impact of environmental education on environmental quality under the background of low-carbon economy
Authors: Wu Ye , Wan Jiawei , Yu Wen
Published: February 2023

Introduction

How does environmental education affect environmental quality? There is no consensus among theorists. This paper is devoted to exploring the influence mechanism of environmental education and environmental quality under the background of a low-carbon economy from a theoretical model and empirical analysis.

Methods

The research method of this paper includes two aspects. First, from the consideration of the central planner, this paper draws on and improves the Ramsey Model to explore the interaction mechanism among environmental education, environmental quality and green growth. Second, this paper uses provincial panel data from China from 2011 to 2017 for empirical analysis, which mainly verifies the impact mechanism of environmental education on environmental quality.

Results and discussion

The theoretical model shows that environmental education enhances green consumption intention through residents' environmental awareness and enhances enterprises' cleaner production motivation through environmental pressure. Correspondingly, the pressure to improve environmental quality will also promote the economy's endogenous growth through the digital economy's transformation and the accumulation of human capital. The empirical analysis confirms that environmental education can improve environmental quality through green consumption and pollution control. Still, the effect of improving environmental quality only through pollution control is not apparent, and pollution control needs to be combined with environmental education, especially in high-pollution areas. Finally, this paper puts forward some suggestions for optimizing environmental education.
Health care professionals' knowledge and attitudes toward telemedicine
Authors: Bashir Muhammad Salman , Lalithabai Diana Selvamony , AlOtaiby Shahad , Abu-Shaheen Amani
Published: February 2023

Background

The utilization of modern communication technology in the healthcare field is known as telemedicine, and it represents an advancement in the healthcare industry. For effective implementation of these technologies, healthcare professionals must possess the appropriate knowledge and hold a positive perspective toward the implementation of telemedicine. The current study aims to evaluate the knowledge and perspective of healthcare professionals in King Fahad Medical City, Saudi Arabia toward telemedicine.

Methods

This study was carried out in a diverse hospital, King Fahad Medical City, Saudi Arabia and it was a cross-sectional study. The study took place from June 2019 until February 2020, during which 370 healthcare professionals, including physicians, nurses, and other healthcare professionals participated. The data was gathered by using a structured self-administered questionnaire.

Results

The analysis of the data revealed that the majority of the healthcare professionals who participated in the study, 237 (63.7%), had limited knowledge of telemedicine. About 41 (11%) participants had a good understanding of the technology, and 94 participants (25.3%) had extensive knowledge. The overall attitude of the participants toward telemedicine was positive, with a mean score of 3.26. The mean attitude scores varied significantly (P < 0.001) among the different professions, with physicians scoring 3.69, allied healthcare professionals scoring 3.31, and nurses scoring 3.07. The coefficient of determination (R2) was used to evaluate the variation in attitude toward telemedicine and it was found that education (12.4%) and nationality (4.7%) had the least impact on the attitude toward telemedicine.

Conclusion

Healthcare professionals are crucial to the successful implementation and continuity of telemedicine. However, despite their positive attitude toward telemedicine, most of the healthcare professionals who participated in the study had limited knowledge of it. There were differences in attitude among different groups of healthcare professionals. As a result, it is necessary to create specialized educational programs for healthcare professionals to guarantee the proper implementation and continuation of telemedicine.
Shift work is significantly and positively associated with dementia: A meta-analysis study
Authors: Lee Kuo-Wei , Yang Chen-Cheng , Chen Chun-Hung , Hung Chih-Hsing , Chuang Hung-Yi
Published: February 2023

Background

Shift work may disrupt the sleep and wake cycles and negatively affect physical and mental health. Dementia is a neurodegenerative disorder with progressively declining cognition that is receiving increasing attention. Studies on the association between shift work and dementia are rare. Herein, we conducted a meta-analysis to investigate the association between shift work and dementia.

Materials and methods

This study was conducted according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. We searched the PubMed, Embase, and Web of Science databases using a related set of keywords. The inclusion criteria were as follows: (1) adult employees working in a factory, company, or organization; (2) exposure to shift work/non-shift work; and (3) outcome of dementia based on examination or assessment. A meta-analysis using a fixed-effects model was performed. The hazard ratio of dementia was compared between shift workers and non-shift workers.

Results

Five studies were included in the quantitative synthesis, and two were selected for further meta-analysis. A random-effects model showed a modest association between shift work and an increase in dementia cases (pooled hazard ratio = 1.13; 95% confidence interval: 1.04–1.23; p = 0.04). This association also occurred in night workers for more than 1 year.

Conclusion

Shift work and long-term night work were modestly associated with a higher risk of developing dementia. Avoiding long-term night shifts may be effective in reducing dementia risk. Further studies are required to confirm this hypothesis.
An integrative approach to dementia care
Authors: Warren Alison
Published: February 2023

As the aging population continues to increase, Alzheimer’s disease and related dementias are becoming a global health crisis. The burdens experienced by the person living with dementia, their caregivers, healthcare, and society persist unabated. Persons with dementia represent an important population in need of a tenable care plan. Caregivers need the tools with which to properly care for these persons and to mitigate their own stress response. A viable healthcare model utilizing integrated approaches to care for persons with dementia is in overwhelming demand. While much research is focused on a cure, it is equally important to address the difficulties faced by those currently affected. One approach is to incorporate interventions to increase quality of life within the caregiver-patient dyad via a comprehensive integrative model. Improving daily life of the persons with dementia, along with their caregivers and loved ones may aid in attenuating the pervasive psychological and physical impacts of this disease. A focus on interventions that provide neural and physical stimulation may facilitate quality of life in this regard. The subjective experience of this disease is challenging to capture. The relationship between neurocognitive stimulation and quality of life is at least, in part, therefore still uncertain. This narrative review aims to explore the efficacy and evidence-base of an integrative approach to dementia care in facilitating optimal cognition and quality of life outcomes. These approaches will be reviewed alongside person-centered care that is fundamental to integrative medicine, including exercise; music; art and creativity; nutrition; psychosocial engagement; memory training; and acupuncture.
Decentralized governance and artificial intelligence policy with blockchain-based voting in federated learning
Authors: Lee C. Alisdair , Chow K. M. , Chan H. Anthony , Lun Daniel Pak-Kong
Published: February 2023

Introduction

Fruit losses in the supply chain owing to improper handling and a lack of proper control are common in the industry. As losses are caused by the inefficiency of the export method, selecting the appropriate export method is a possible solution. Several organizations employ only a single strategy, which is mainly based on a first-in-first-out approach. Such a policy is easy to manage but inefficient. Given that the batch of fruits may become overripe during transportation, frontline operators do not have the authority or immediate support to change the fruit dispatching strategy. Thus, this study aims to develop a dynamic strategy simulator to determine the sequence of delivery based on forecasting information projected from probabilistic data to reduce the amount of fruit loss.

Methods

The proposed method to accomplish asynchronous federated learning (FL) is based on blockchain technology and a serially interacting smart contract. In this method, each party in the chain updates its model parameters and uses a voting system to reach a consensus. This study employs blockchain technology with smart contracts to serially enable asynchronous FL, with each party in the chain updating its parameter model. A smart contract combines a global model with a voting system to reach a common consensus. Its artificial intelligence (AI) and Internet of Things engine further strengthen the support for implementing the Long Short-Term Memory (LSTM) forecasting model. Based on AI technology, a system was constructed using FL in a decentralized governance AI policy on a blockchain network platform.

Results

With mangoes being selected as the category of fruit in the study, the system improves the cost-effectiveness of the fruit (mango) supply chain. In the proposed approach, the simulation outcomes show fewer mangoes lost (0.035%) and operational costs reduced.

Discussion

The proposed method shows improved cost-effectiveness in the fruit supply chain through the use of AI technology and blockchain. To evaluate the effectiveness of the proposed method, an Indonesian mango supply chain business case study has been selected. The results of the Indonesian mango supply chain case study indicate the effectiveness of the proposed approach in reducing fruit loss and operational costs.
Two decades of nighttime surface urban heat island intensity analysis over nine major populated cities of India and implications for heat stress
Authors: Jain Madhavi
Published: February 2023

Warmer global climate and urban heat islands (UHIs) interact, by exacerbating heatwaves and increasing the extreme heat days in cities. The implications of added heat stress in urban environments due to intensifying surface UHIs (SUHIs) is of utmost concern. Seasonal, annual and decadal nighttime SUHI intensities (SUHIIs), from 2001 to 2020, for nine major populated cities of India are analyzed. This includes five megacities- Delhi, Mumbai, Kolkata, Bangalore, and Chennai, and four incipient megacities- Hyderabad, Ahmedabad, Surat, and Pune. The key role of increasing urbanization (pre- and post-2010) in expansion and intensification of nighttime SUHIs in India is highlighted. For all cities either pre-monsoon (MAM) or winter (December-February; DJF) seasons show the strongest SUHII development. During the 2001–2010, and the 2011–2020 decade, a nighttime SUHII maxima of respectively (i) 2.1°C and 2.5°C for Delhi, (ii) 1.3°C and 1.5°C for Mumbai, (iii) 1.3°C and 1.5°C for Kolkata, (iv) 0.6°C and 1.0°C Bangalore, (v) 1.7°C and 1.9°C for Chennai, (vi) 1.8°C and 2.3°C for Hyderabad, (vii) 2.8°C and 3.1°C for Ahmedabad, (viii) 1.9°C and 2.4°C for Surat, and (ix) 0.8°C and 1.3°C for Pune is noted. Further, all incipient megacities showed a mean annual growth rate of nighttime SUHII of over 0.007°C/year, substantially greater than in the megacities. High SUHII magnitudes, greater growth rates of SUHII, and huge populations, severely compounds the vulnerability of Indian cities to excessive heat exposure risk, especially during MAM heatwaves. Lastly, the implications of nighttime SUHII findings from the present study, on the increase in heat stress, the loss of labor productivity and the rise in heat-related mortality rate is emphasized. The study recommends implementation of city-specific action plans to mitigate the heat stressed urban environment. Targeted use of cooling strategies in localized hotspots within the urban areas where high intensity SUHIs are likely to form is also suggested.
Updating viral agents in tomato seeds with new generation diagnostic technologies
Authors: Atik Ayşen Kübra , Paylan İsmail Can
Published: February 2023

The aim of this study is to identify and update the list of viral pathogens in tomato seeds, which plays an important role for our country's economy, and to control, on behalf of our country, viral factors like TYLCV and PepMV, which were thought not to be existing in the past but were determined by new and sensitive methods in the recent years. It is also the aim, if viral pathogens like TYLCV and PepMV are found, to share this findings with the necessary institutions and to update the viral factors which needs to be tested, and the quarantine lists. Two hundred and thirty-eight seed samples were used in this study. Serological and molecular methods were used in order to identify the viral pathogens in the seed samples. Two hundred and thirty-eight seed samples of different tomato varieties were tested in order to prove the possible existence of Tobacco mosaic tobamovirus (TMV), Tomato mosaic tobamovirus (ToMV), Cucumber mosaic cucumovirus (CMV), Tomato yellow leaf curl geminivirus (TYLCV), Tomato spotted wilt tospovirus (TSWV), Pepino mosaic potexvirus (PepMV), Pepper mild mottle tobamovirus (PMMoV), and Tomato brown rugose fruit tobamovirus (ToBRFV) and as a result 12% of the seeds were founded to be infected with TMV, 23% with ToMV and 8% with CMV. Within the scope of this study it was seen that some seed samples have mixed infections. Sixty-seven seeds of the 238 seeds has been found to be infected in this study. This is a rate of 28% were the seeds are infected at least with one viral pathogen.
Increased thrombin activatable fibrinolysis inhibitor activity is associated with hypofibrinolysis in dogs with sepsis
Authors: Sotos Katherine E. , Goggs Robert , Stablein Alyssa P. , Brooks Marjory B.
Published: February 2023

Introduction

Disorders of coagulation are well-recognized in dogs with sepsis, but data regarding fibrinolysis disorders are limited. We aimed to characterize fibrinolysis in dogs with sepsis compared to healthy controls. We hypothesized that dogs with sepsis would be hypofibrinolytic, and that hypofibrinolysis would be associated with non-survival.

Methods

This was a prospective observational cohort study. We enrolled 20 client-owned dogs with sepsis admitted to the Cornell University Hospital for Animals and 20 healthy pet dogs. Coagulation and fibrinolytic pathway proteins including antiplasmin activity (AP), antithrombin activity (AT), thrombin activatable fibrinolysis inhibitor activity (TAFI), D-dimer concentration, fibrinogen concentration, and plasminogen activity were measured and compared between groups. Overall coagulation potential, overall fibrinolysis potential, and overall hemostatic potential were calculated from the curve of fibrin clot formation and lysis over time.

Results

Compared to healthy controls, dogs with sepsis had lower AT (P= 0.009), higher AP (P= 0.002), higher TAFI (P= 0.0385), and higher concentrations of fibrinogen (P< 0.0001) and D-dimer (P= 0.0001). Dogs with sepsis also had greater overall coagulation potential (P= 0.003), overall hemostatic potential (P= 0.0015), and lower overall fibrinolysis potential (P= 0.0004). The extent of fibrinolysis was significantly negatively correlated with TAFI. No significant differences were observed between survivors and non-survivors.

Discussion

Dogs with sepsis were hypercoagulable and hypofibrinolytic compared to healthy dogs, suggesting potential utility of thromboprophylaxis in this patient population. The association between high TAFI and low overall fibrinolysis potential might provide a potential mechanism for this hypofibrinolysis.
Effects of concurrent administration of modified live viral vaccines with RB51 on immune responses to RB51
Authors: Crawford Lauren , Falkenberg Shollie , Putz Ellie Jordan , Olsen Steven , Boggiatto Paola M.
Published: February 2023

Brucella abortus is a gram negative, zoonotic pathogen that can cause abortions and stillbirths in the cattle industry and has contributed to significant economic losses to cow-calf producers. Cell mediated immunity (CMI) is an important component of the immune response associated with protection against Brucella abortus and other intracellular pathogens. Brucellosis and viral modified live vaccines (vMLV) are licensed individually but may be used concurrently under field conditions. Peripheral blood mononuclear cells (PBMC) from non-vaccinated cattle and cattle vaccinated with either Brucella abortus strain RB51, a vMLV or both RB51 and a vMLV vaccine were isolated. The frequency of CD4+, CD8+ and γδ+ T cell populations within PBMC, and the frequency of interferon gamma (IFN-γ) production within these cell types was characterized via flow-cytometry. The goal of this study was to characterize immune responses to RB51 vaccination and determine the effect of concurrent vaccine administration. Although immune responses were greatest in PBMC from cattle vaccinated with only RB51, cattle vaccinated with both RB51 and vMLV demonstrated measurable T cell responses associated with protective immunity. Data suggests a lack of significant biological differences between the groups in protective immune responses. Collectively, our data demonstrated a lack of vaccine interference following concurrent administration of vMLV and RB51. Although concurrent administration of individually licensed vaccines may influence immune responses and contribute to vaccine interference, potential vaccine combinations should be evaluated for biological effects.
Phenotypes and genetic etiology of spontaneous polycystic kidney and liver disease in cynomolgus monkey
Authors: Wu Ruo , Bai Bing , Li Feng , Bai Raoxian , Zhuo Yan , Zhu Zhengna , Jia Rongfang , Li Shangang , Chen Yongchang , Lan Xiaoping
Published: February 2023

Introduction

Polycystic kidney disease (PKD) is a common autosomal dominant or recessive genetic disease, often accompanied by polycystic liver disease (PLD). Many cases of PKD in animals have been reported. However, little is known about the genes that cause PKD in animals.

Methods

In this study, we evaluated the clinical phenotypes of PKD in two spontaneously aged cynomolgus monkeys and explored the genetic etiology using whole-genome sequencing (WGS). Ultrasonic and histological consequences were further investigated in PKD- and PLD-affected monkeys.

Results

The results indicated that the kidneys of the two monkeys had varying degrees of cystic changes, and the renal cortex was thinned and accompanied by fluid accumulation. As for hepatopathy, inflammatory cell infiltration, cystic effusion, steatosis of hepatocytes, and pseudo-lobular were found. Based on WGS results, the variants of PKD1:(XM_015442355: c.1144G>C p. E382Q) and GANAB: (NM_001285075.1: c.2708T>C/p. V903A) are predicted to be likely pathogenic heterozygous mutations in PKD- and PLD-affected monkeys.

Discussion

Our study suggests that the cynomolgus monkey PKD and PLD phenotypes are very similar to those in humans, and are probably caused by pathogenic genes homologous to humans. The results indicate that cynomolgus monkeys can be used as the most appropriate animal model for human PKD pathogenesis research and therapeutic drug screening.
Risk Factors for Working Pregnant Women and Potential Adverse Consequences of Exposure: A Systematic Review
Authors: Corchero-Falcón María del Rocío , Gómez-Salgado Juan , García-Iglesias Juan Jesús , Camacho-Vega Juan Carlos , Fagundo-Rivera Javier , Carrasco-González Ana María
Published: February 2023

Objective: To assess the risk factors perceived as stressors by pregnant women in the work environment and the possible adverse consequences of such exposure for the normal development of pregnancy.

Methods: Systematic review, guided by the PRISMA guidelines, and using Pubmed, Web of Science, Dialnet, SciELO, and REDIB databases. Methodological quality was assessed using the critical appraisal tools for non-randomised studies of the Joanna Briggs Institute.

Results: A total of 38 studies were included. The main risk factors found in the work environment of pregnant women were chemical, psychosocial, physical-ergonomic-mechanical factors, and other work-related factors. The main adverse consequences of exposure to these factors include low birth weight, preterm birth, miscarriage, hypertension and pre-eclampsia, as well as various obstetric complications.

Conclusion: During pregnancy, working conditions that are considered acceptable in normal situations may not be so during this stage due to the major changes that occur during pregnancy. Many obstetric effects may have an important impact in the mother’s psychological status; therefore, it is important to optimise working conditions during this stage and to reduce or eliminate possible risks.
Evaluation of the Effect of ‘Candidatus Liberibacter Solanacearum’ Haplotypes in Tobacco Infection
Authors: Levy Julien G. , Mendoza-Herrera Azucena , Merchant Naveed , Berg-Falloure Katherine M. , Kolomiets Michael V. , Tamborindeguy Cecilia
Published: February 2023

‘Candidatus Liberibacter solanacearum’ (Lso) is a phloem-limited bacterial plant pathogen infecting solanaceous plants in the Americas and New Zealand and is associated with diseases of apiaceous crops in Europe, Northern Africa, and the Middle East. This pathogen is also related to other Liberibacter species that infect other crops. In the USA, two haplotypes of Lso, LsoA and LsoB, are predominant and responsible for diseases in potato and tomato. Tobacco, Nicotiana tabacum, a model species to study plant defenses, is a host for Lso; therefore, the interaction between Lso and this host plant could be used to study Liberibacter−plant interactions. In this study, we characterized the infection associated with LsoA and LsoB in tobacco. Under laboratory conditions, LsoB caused more severe symptoms than LsoA, and LsoA and LsoB titers were dynamic during the 7 weeks of the experiment. We also measured SA and other metabolites, including oxylipins, at an early point of infection and found that SA was accumulated in plants infected with LsoB but not with LsoA; whereas ABA levels were reduced in LsoA- but not in LsoB-infected plants.
The Canine Pancreatic Extracellular Matrix in Diabetes Mellitus and Pancreatitis: Its Essential Role and Therapeutic Perspective
Authors: Pantoja Bruna Tássia dos Santos , Carvalho Rafael Cardoso , Miglino Maria Angelica , Carreira Ana Claudia Oliveira
Published: February 2023

Diabetes mellitus and pancreatitis are common pancreatic diseases in dogs, affecting the endocrine and exocrine portions of the organ. Dogs have a significant role in the history of research related to genetic diseases, being considered potential models for the study of human diseases. This review discusses the importance of using the extracellular matrix of the canine pancreas as a model for the study of diabetes mellitus and pancreatitis, in addition to focusing on the importance of using extracellular matrix in new regenerative techniques, such as decellularization and recellularization. Unlike humans, rabbits, mice, and pigs, there are no reports in the literature characterizing the healthy pancreatic extracellular matrix in dogs, in addition to the absence of studies related to matrix components that are involved in triggering diabetes melittus and pancreatitis. The extracellular matrix plays the role of physical support for the cells and allows the regulation of various cellular processes. In this context, it has already been demonstrated that physiologic and pathologic pancreatic changes lead to ECM remodeling, highlighting the importance of an in-depth study of the changes associated with pancreatic diseases.