bluuebunny/crossref_metadata_2025 huggingface dataset:
Sorption of CO2 and CH4 on Raw and Calcined Halloysite—Structural and Pore Characterization Study
Authors: Pajdak Anna , Skoczylas Norbert , Szymanek Arkadiusz , Lutyński Marcin , Sakiewicz Piotr
Published: February 2020

The article presents comparative characteristics of the pore structure and sorption properties of raw halloysite (R-HAL) and after calcination (C-HAL) at the temperature of 873 K. Structural parameters were determined by optical scanning and transmission electron microscopy methods as well as by mercury porosimetry (MIP, Hg) and low-pressure nitrogen adsorption (LPNA, N2, 77 K). The surface area parameter (LPNA) of halloysite mesopores before calcination was 54–61 m2/g. Calcining caused the pore surface to develop to 70–73 m2/g. The porosity (MIP) of halloysite after calcination increased from 29% to 46%, while the surface area within macropores increased from 43 m2/g to 54 m2/g. The total pore volume within mesopores and macropores increased almost twice after calcination. The course of CH4 and CO2 sorption on the halloysite was examined and sorption isotherms (0–1.5 MPa, 313 K) were determined by gravimetric method. The values of equilibrium sorption capacities increased at higher pressures. The sorption capacity of CH4 in R-HAL was 0.18 mmol/g, while in C-HAL 0.21 mmol/g. CO2 sorption capacities were 0.54 mmol/g and 0.63 mmol/g, respectively. Halloysite had a very high rate of sorption equilibrium. The values of the effective diffusion coefficient for methane on the tested halloysite were higher than De > 4.2 × 10−7 cm2/s while for carbon dioxide De > 3.1 × 10−7 cm2/s.
Development of Precipitation Hardening Parameters for High Strength Alloy AA 7068
Authors: Osten Julia , Milkereit Benjamin , Reich Michael , Yang Bin , Springer Armin , Nowak Karina , Kessler Olaf
Published: February 2020

The mechanical properties after age hardening heat treatment and the kinetics of related phase transformations of high strength AlZnMgCu alloy AA 7068 were investigated. The experimental work includes differential scanning calorimetry (DSC), differential fast scanning calorimetry (DFSC), sophisticated differential dilatometry (DIL), scanning electron microscopy (SEM), as well as hardness and tensile tests. For the kinetic analysis of quench induced precipitation by dilatometry new metrological methods and evaluation procedures were established. Using DSC, dissolution behaviour during heating to solution annealing temperature was investigated. These experiments allowed for identification of the appropriate temperature and duration for the solution heat treatment. Continuous cooling experiments in DSC, DFSC, and DIL determined the kinetics of quench induced precipitation. DSC and DIL revealed several overlapping precipitation reactions. The critical cooling rate for a complete supersaturation of the solid solution has been identified to be 600 to 800 K/s. At slightly subcritical cooling rates quench induced precipitation results in a direct hardening effect resulting in a technological critical cooling rate of about 100 K/s, i.e., the hardness after ageing reaches a saturation level for cooling rates faster than 100 K/s. Maximum yield strength of above 600 MPa and tensile strength of up to 650 MPa were attained.
On the Determination of Forming Limits in Polycarbonate Sheets
Authors: Rosa-Sainz Ana , Centeno Gabriel , Silva Maria Beatriz , López-Fernández Jose Andrés , Martínez-Donaire Andrés Jesus , Vallellano Carpoforo
Published: February 2020

By proposing an adaptation of the methodology usually used in metal forming, this paper aims to provide a general procedure for determining the forming limits, by necking and fracture, of polymeric sheet. The experimental work was performed by means of Nakajima specimens with different geometries to allow to obtain strains in the tensile, plane, biaxial and equibiaxial states for Polycarbonate sheet with 1 mm of thickness. The application of the time-dependent and flat-valley approaches used in metals has been revealed appropriate to characterize the onset of necking and obtain the forming limits of polycarbonate, despite the stable necking propagation typical of polymeric sheets. An analysis of the evolution of the strain paths along a section perpendicular to the crack allowed for a deeper understanding of the steady necking propagation behaviour and the adoption of the methodology of metals to polymers. The determination of the fracture strains was enhanced with the consideration of the principal strains of the DIC system in the last stage, just before fracture, due to the significant elastic recovery typical of polymeric sheets. As a result of this analysis, accurate formability limits by necking and fracture are obtained for polycarbonate sheet, together with the principal strain space, providing a general framework for analysing incremental sheet forming processes where the knowledge of the fracture limits is relevant.
A Numerical Study of the Effect of Component Dimensions on the Critical Buckling Load of a GFRP Composite Strut under Uniaxial Compression
Authors: Doan Quoc Hoan , Thai Duc-Kien , Tran Ngoc Long
Published: February 2020

In the practical design of thin-walled composite columns, component dimensions should be wisely designed to meet the buckling resistance and economic requirements. This paper provides a novel and useful investigation based on a numerical study of the effects of the section dimensions, thickness ratio, and slenderness ratio on the critical buckling load of a thin-walled composite strut under uniaxial compression. The strut was a channel-section-shaped strut and was made of glass fiber-reinforced polymer (GFRP) composite material by stacking symmetrical quasi-isotropic layups using the autoclave technique. For the purpose of this study, a numerical finite element model was developed for the investigation by using ABAQUS software. The linear and post-buckling behavior analysis was performed to verify the results of the numerical model with the obtained buckling load from the experiment. Then, the effects of the cross-section dimensions, thickness ratio, and slenderness ratio on the critical buckling load of the composite strut, which is determined using an eigenvalue buckling analysis, were investigated. The implementation results revealed an insightful interaction between cross-section dimensions and thickness ratio and the buckling load. Based on this result, a cost-effective design was recommended as a useful result of this study. Moreover, a demarcation point between global and local buckling of the composite strut was also determined. Especially, a new design curve for the channel-section GFRP strut, which is governed by the proposed constitutive equations, was introduced to estimate the critical buckling load based on the input component dimension.
Relevant Aspects for an EF3-Evaluation of E-Cognocracy
Authors: Moreno-Jiménez José María , Pérez-Espés Cristina , Rivera-Torres Pilar
Published: February 2020

The search for an appropriate response to the new challenges and needs posed by the Knowledge Society in the area of public decisions has led to the development of a number of participation models whose value must be assessed and analysed in an integral manner. Using a theoretical model based on structural equations, the present work identifies the relevant factors for an EF3-approach to the democracy model named e-Cognocracy: it comprises a conjoint evaluation of its effectiveness (doing what is right), efficacy (achieving goals) and efficiency (doing things correctly). The model was applied to a real-life e-Cognocracy experience undertaken in the municipality of Cadrete, Zaragoza. The evaluation resulted in the extraction and identification of a series of relationships that allow the advancement of an EF3-participation acceptance model, in line with the TAM model of Davis and the work of Delone and MacLean, which can be used for the integral evaluation of any e-participation model.
On Reliability of a Double Redundant Renewable System with a Generally Distributed Life and Repair Times
Authors: Rykov Vladimir , Efrosinin Dmitry , Stepanova Natalia , Sztrik Janos
Published: February 2020

The paper provides reliability analysis of a cold double redundant renewable system assuming that both life-time and repair time distributions are arbitrary. The proposed approach is based on the theory of decomposable semi-regenerative processes. We derive the Laplace–Stieltjes transform of two main reliability measures like the distribution of the time between failures and the time to the first failure. The transforms are used to calculate corresponding mean times. It is further derived in closed form the time-dependent and time stationary state probabilities in terms of the Laplace transforms. Numerical results illustrate the effect of the type of distributions as well as their parameters on the derived reliability and probabilistic measures.
A Spectral Conjugate Gradient Method with Descent Property
Authors: Jian Jinbao , Yang Lin , Jiang Xianzhen , Liu Pengjie , Liu Meixing
Published: February 2020

Spectral conjugate gradient method (SCGM) is an important generalization of the conjugate gradient method (CGM), and it is also one of the effective numerical methods for large-scale unconstrained optimization. The designing for the spectral parameter and the conjugate parameter in SCGM is a core work. And the aim of this paper is to propose a new and effective alternative method for these two parameters. First, motivated by the strong Wolfe line search requirement, we design a new spectral parameter. Second, we propose a hybrid conjugate parameter. Such a way for yielding the two parameters can ensure that the search directions always possess descent property without depending on any line search rule. As a result, a new SCGM with the standard Wolfe line search is proposed. Under usual assumptions, the global convergence of the proposed SCGM is proved. Finally, by testing 108 test instances from 2 to 1,000,000 dimensions in the CUTE library and other classic test collections, a large number of numerical experiments, comparing with both SCGMs and CGMs, for the presented SCGM are executed. The detail results and their corresponding performance profiles are reported, which show that the proposed SCGM is effective and promising.
An Extended EDAS Method with a Single-Valued Complex Neutrosophic Set and Its Application in Green Supplier Selection
Authors: Xu Dongsheng , Cui Xiangxiang , Xian Huaxiang
Published: February 2020

The single-valued complex neutrosophic set is a useful tool for handling the data with uncertainty and periodicity. In this paper, a single-valued complex neutrosophic EDAS (evaluation based on distance from average slution) model has been established and applied in green supplier selection. Firstly, the definition of single-valued complex neutrosophic set and corresponding operational laws are briefly introduced. Next, to fuse overall single-valued complex neutrosophic information, the SVCNEWA and SVCNEWG operators based on single-valued complex neutrosophic set, Einstein product and sum are proposed. Furthermore, the single-valued complex neutrosophic EDAS model has been established and all computing steps have been depicted in detail. Finally, a numerical example of green supplier selection and a comparison analysis have been given to illustrate the practicality and effectiveness of this new model.
Multi-Omic Profiling of Melophlus Sponges Reveals Diverse Metabolomic and Microbiome Architectures that Are Non-overlapping with Ecological Neighbors
Authors: Mohanty Ipsita , Podell Sheila , Biggs Jason S. , Garg Neha , Allen Eric E. , Agarwal Vinayak
Published: February 2020

Marine sponge holobionts, defined as filter-feeding sponge hosts together with their associated microbiomes, are prolific sources of natural products. The inventory of natural products that have been isolated from marine sponges is extensive. Here, using untargeted mass spectrometry, we demonstrate that sponges harbor a far greater diversity of low-abundance natural products that have evaded discovery. While these low-abundance natural products may not be feasible to isolate, insights into their chemical structures can be gleaned by careful curation of mass fragmentation spectra. Sponges are also some of the most complex, multi-organismal holobiont communities in the oceans. We overlay sponge metabolomes with their microbiome structures and detailed metagenomic characterization to discover candidate gene clusters that encode production of sponge-derived natural products. The multi-omic profiling strategy for sponges that we describe here enables quantitative comparison of sponge metabolomes and microbiomes to address, among other questions, the ecological relevance of sponge natural products and for the phylochemical assignment of previously undescribed sponge identities.
A Microfluidic Mixer of High Throughput Fabricated in Glass Using Femtosecond Laser Micromachining Combined with Glass Bonding
Authors: Qi Jia , Li Wenbo , Chu Wei , Yu Jianping , Wu Miao , Liang Youting , Yin Difeng , Wang Peng , Wang Zhenhua , Wang Min , Cheng Ya
Published: February 2020

We demonstrate a microfluidic mixer of high mixing efficiency in fused silica substrate using femtosecond laser-induced wet etching and hydroxide-catalysis bonding method. The micromixer has a three-dimensional geometry, enabling efficient mixing based on Baker’s transformation principle. The cross-sectional area of the fabricated micromixer was 0.5 × 0.5 mm2, enabling significantly promotion of the throughput of the micromixer. The performance of the fabricated micromixers was evaluated by mixing up blue and yellow ink solutions with a flow rate as high as 6 mL/min.
Antimicrobial Peptides: Virulence and Resistance Modulation in Gram-Negative Bacteria
Authors: Duperthuy Marylise
Published: February 2020

Growing resistance to antibiotics is one of the biggest threats to human health. One of the possibilities to overcome this resistance is to use and develop alternative molecules such as antimicrobial peptides (AMPs). However, an increasing number of studies have shown that bacterial resistance to AMPs does exist. Since AMPs are immunity molecules, it is important to ensure that their potential therapeutic use is not harmful in the long term. Recently, several studies have focused on the adaptation of Gram-negative bacteria to subinhibitory concentrations of AMPs. Such concentrations are commonly found in vivo and in the environment. It is therefore necessary to understand how bacteria detect and respond to low concentrations of AMPs. This review focuses on recent findings regarding the impact of subinhibitory concentrations of AMPs on the modulation of virulence and resistance in Gram-negative bacteria.
Evaluation of Potential Probiotics Bacillus subtilis WB60, Pediococcus pentosaceus, and Lactococcus lactis on Growth Performance, Immune Response, Gut Histology and Immune-Related Genes in Whiteleg Shrimp, Litopenaeus vannamei
Authors: Won Seonghun , Hamidoghli Ali , Choi Wonsuk , Bae Jinho , Jang Won Je , Lee Seunghan , Bai Sungchul C.
Published: February 2020

An eight-week feeding trial was conducted to evaluate the effects of different dietary probiotic supplements in juvenile whiteleg shrimp, Litopenaeus vannamei. A basal control diet without probiotics (CON), and five other diets by supplementing Bacillus subtilis at 107 CFU/g diet (BS7), B. subtilis (BS8), Pediococcus pentosaceus (PP8), and Lactococcus lactis (LL8) at 108 CFU/g diet, and oxytetracycline (OTC) at 4 g/kg diet were used. Whiteleg shrimp with initial body weights of 1.41 ± 0.05 g (mean ± SD) were fed with these diets. Growth of shrimp fed BS8 and LL8 diets was significantly higher than those of shrimp fed the CON diet (p < 0.05). Superoxide dismutase activity in shrimp fed PP8 and LL8 diets was significantly higher than that of shrimp fed the CON diet (p < 0.05). Lysozyme activity of shrimp fed probiotics and OTC diets significantly improved compared to those on the CON diet (p < 0.05). The intestinal histology showed healthier guts for shrimp fed the probiotic diets (p < 0.05). Immune-related gene expression in shrimp fed BS8, PP8 and LL8 diets was recorded as significantly higher than that of shrimp fed CON and OTC diets (p < 0.05). Also, results of the challenge test for 7 days and the digestive enzyme activity of shrimp fed BS8, PP8, and LL8 were significantly improved compared to those on the CON diet (p < 0.05). Therefore, these results indicated that L. lactis at 108 CFU/g could be an ideal probiotic for whiteleg shrimp, and also B. subtilis WB60 and P. pentosaceus at 108 CFU/g could improve the growth, immunity, histology, gene expression, digestive enzyme activity, and disease resistance, while replacing antibiotics.
Development of a Lyophilization Process for Campylobacter Bacteriophage Storage and Transport
Authors: Liang Lu , Carrigy Nicholas B. , Kariuki Samuel , Muturi Peter , Onsare Robert , Nagel Tobi , Vehring Reinhard , Connerton Phillippa L. , Connerton Ian F.
Published: February 2020

Bacteriophages are a sustainable alternative to control pathogenic bacteria in the post-antibiotic era. Despite promising reports, there are still obstacles to phage use, notably titer stability and transport-associated expenses for applications in food and agriculture. In this study, we have developed a lyophilization approach to maintain phage titers, ensure efficacy and reduce transport costs of Campylobacter bacteriophages. Lyophilization methods were adopted with various excipients to enhance stabilization in combination with packaging options for international transport. Lyophilization of Eucampyvirinae CP30A using tryptone formed a cake that limited processing titer reduction to 0.35 ± 0.09 log10 PFU mL−1. Transmission electron microscopy revealed the initial titer reduction was associated with capsid collapse of a subpopulation. Freeze-dried phages were generally stable under refrigerated vacuum conditions and showed no significant titer changes over 3 months incubation at 4 °C (p = 0.29). Reduced stability was observed for lyophilized phages that were incubated either at 30 °C under vacuum or at 4 °C at 70% or 90% relative humidity. Refrigerated international transport and rehydration of the cake resulted in a total phage titer reduction of 0.81 ± 0.44 log10 PFU mL−1. A significantly higher titer loss was observed for phages that were not refrigerated during transport (2.03 ± 0.32 log10 PFU mL−1). We propose that lyophilization offers a convenient method to preserve and transport Campylobacter phages, with minimal titer reduction after the drying process.
The Effect of Posaconazole, Itraconazole and Voriconazole in the Culture Medium on Aspergillus fumigatus Triazole Resistance
Authors: Mroczyńska Martyna , Kurzyk Ewelina , Śliwka-Kaszyńska Magdalena , Nawrot Urszula , Adamik Marta , Brillowska-Dąbrowska Anna
Published: February 2020

Triazoles are the only compounds used as antibiotics in both medicine and agriculture. The presence of triazoles in the environment can contribute to the acquisition of azole resistance among isolates of Aspergillus fumigatus. The objective of this study was to investigate the effect of A. fumigatus exposure to triazoles on susceptibility to these compounds. Seventeen triazole-resistant and 21 triazole-sensitive A. fumigatus isolates were examined. The isolates were transferred 20 times on the Sabouraud medium supplemented with posaconazole, itraconazole or voriconazole, followed by five times on the medium not supplemented. The minimum inhibitory concentrations of antimycotics were examined according to the EUCAST broth microdilution method after the 20th transfer and also the 25th transfer. In addition, the expression levels of genes mdr1, mdr2, mdr3, atrF, cyp51A and cyp51B were determined. Cultivation of A. fumigatus on media supplemented with posaconazole, itraconazole and voriconazole resulted in the acquisition of resistance to the tested triazoles of all examined isolates. After recultivation on Sabouraud without azoles, most of the isolates lost their acquired resistance. The long-term use of triazole compounds in agriculture may result in the occurrence of triazole resistant A. fumigatus isolates in the environment, not only by induction or selection of mutations in the cyp51A gene, but also by contribution to changes in the gene expression.
Postural Balance Effects Associated with 400, 4000 or 10,000 IU Vitamin D3 Daily for Three Years: A Secondary Analysis of a Randomized Clinical Trial
Authors: Burt Lauren A. , Gabel Leigh , Billington Emma O. , Hanley David A. , Boyd Steven K.
Published: February 2020

Vitamin D supplementation is proposed as a fall prevention strategy, as it may improve neuromuscular function. We examined whether three years of vitamin D supplementation (400, 4000 or 10,000 IU daily) affects postural sway in older adults. Three hundred and seventy-three non-osteoporotic, vitamin D-sufficient, community-dwelling healthy adults, aged 55–70 years, were randomized to 400 (n = 124), 4000 (n = 125) or 10,000 (n = 124) IU daily vitamin D3 for three years. Sway index was assessed at baseline, 12-, 24- and 36-months using the Biosway machine. We tested participants under four conditions: eyes open or eyes closed with firm (EOFI, ECFI) or foam (EOFO, ECFO) surfaces. Secondary assessments examined sway in the anterior-posterior (AP) and medio-lateral (ML) directions. Linear mixed effects models compared sway between supplementation groups across time. Postural sway under EOFO and ECFO conditions significantly improved in all supplementation groups over time. Postural sway did not differ between supplementation groups at any time under any testing conditions in normal, AP or ML directions (p > 0.05 for all). Our findings suggest that high dose (4000 or 10,000 IU) vitamin D supplementation neither benefit nor impair balance compared with 400 IU daily in non-osteoporotic, vitamin D-sufficient, healthy older adults.
Impact of Dietary Interventions during Pregnancy on Maternal, Neonatal, and Child Outcomes in Low- and Middle-Income Countries
Authors: Lassi Zohra S , Padhani Zahra A , Rabbani Amna , Rind Fahad , Salam Rehana A. , Das Jai K , Bhutta Zulfiqar A
Published: February 2020

Optimal nutrition plays a crucial role in pregnancy. Maternal malnutrition is a risk factor for maternal, fetal, and neonatal complications and is more prevalent in low and middle-income countries (LMICs). This review aims to study the effectiveness of antenatal macronutrient nutritional interventions on maternal, neonatal, and child outcomes. We searched the CENTRAL, PubMed, Embase, and other databases for randomized controlled trials and quasi-experimental designs on healthy pregnant women in LMICs. We also searched grey literature and reports from Google Scholar, Web of Science, and websites of different organizations. Title/abstract screening, full-text screening, and data extraction filtered 15 studies for inclusion. Balanced energy protein (BEP) supplementation (n = 8) studies showed a reduced incidence of perinatal mortality, stillbirths, low birth weight (LBW) infants, small for gestational age (SGA) babies and increased birth weight. Food distribution programs (FDPs) (n =5) witnessed reduced rates of SGA, stunting, wasting, and increased birth weight and birth length. Studies on intervention for obesity prevention (n = 2) showed reductions in birth weight. Other findings were statistically insignificant. Subgroup analyses were conducted to study the effectiveness of supplementation between regions, location, the timing of supplementation and nutritional status; however, there were a limited number of studies in each subgroup. Data from our review supports the antenatal supplementation of BEP and FDP for the prevention of adverse maternal, neonatal, and child outcomes that can be utilized for future policymaking. However, more research is required before recommending obesity prevention programs.
The Relationship between Glycemic Index and Health
Authors: Brand-Miller Jennie , Buyken Anette E.
Published: February 2020

There is no question that elevated postprandial glycemia is a significant driver of common chronic diseases globally [...]
Targeting Mitochondrial Calcium Uptake with the Natural Flavonol Kaempferol, to Promote Metabolism/Secretion Coupling in Pancreatic β-cells
Authors: Bermont Flavien , Hermant Aurelie , Benninga Romy , Chabert Christian , Jacot Guillaume , Santo-Domingo Jaime , Kraus Marine R-C , Feige Jerome N. , De Marchi Umberto
Published: February 2020

Pancreatic β-cells secrete insulin to lower blood glucose, following a meal. Maintenance of β-cell function is essential to preventing type 2 diabetes. In pancreatic β-cells, mitochondrial matrix calcium is an activating signal for insulin secretion. Recently, the molecular identity of the mitochondrial calcium uniporter (MCU), the transporter that mediates mitochondrial calcium uptake, was revealed. Its role in pancreatic β-cell signal transduction modulation was clarified, opening new perspectives for intervention. Here, we investigated the effects of a mitochondrial Ca2+-targeted nutritional intervention strategy on metabolism/secretion coupling, in a model of pancreatic insulin-secreting cells (INS-1E). Acute treatment of INS-1E cells with the natural plant flavonoid and MCU activator kaempferol, at a low micromolar range, increased mitochondrial calcium rise during glucose stimulation, without affecting the expression level of the MCU and with no cytotoxicity. Enhanced mitochondrial calcium rises potentiated glucose-induced insulin secretion. Conversely, the MCU inhibitor mitoxantrone inhibited mitochondrial Ca2+ uptake and prevented both glucose-induced insulin secretion and kaempferol-potentiated effects. The kaempferol-dependent potentiation of insulin secretion was finally validated in a model of a standardized pancreatic human islet. We conclude that the plant product kaempferol activates metabolism/secretion coupling in insulin-secreting cells by modulating mitochondrial calcium uptake.
Nonleptonic Decays of Doubly Charmed Baryons
Authors: Ivanov Mikhail A.
Published: February 2020

In this lecture, we provide a basic introduction into the topic of charmed baryons and their nonleptonic two-body decays. Some features of the baryon weak decays on the quark level are discussed in detail in the framework of effective field theory. The calculation of the matrix elements of the four-quark operators arising in the effective theory proceeds by using the covariant constituent quark model. The model allows one to evaluate not only the factorizing tree-level diagrams but also more complicated diagrams with the internal W–exchange. The technique required for such calculation is discussed in some detail. Finally, the numerical results are presented, and comparison of the contributions coming from the W–exchange diagrams with those from the tree-level are carefully performed.
Engineering of Live Chimeric Vaccines against Human Metapneumovirus
Authors: Ogonczyk Makowska Daniela , Hamelin Marie-Ève , Boivin Guy
Published: February 2020

Human metapneumovirus (HMPV) is an important human pathogen that, along with respiratory syncytial virus (RSV), is a major cause of respiratory tract infections in young infants. Development of an effective vaccine against Pneumoviruses has proven to be particularly difficult; despite over 50 years of research in this field, no vaccine against HMPV or RSV is currently available. Recombinant chimeric viruses expressing antigens of other viruses can be generated by reverse genetics and used for simultaneous immunization against more than one pathogen. This approach can result in the development of promising vaccine candidates against HMPV, and several studies have indeed validated viral vectors expressing HMPV antigens. In this review, we summarize current efforts in generating recombinant chimeric vaccines against HMPV, and we discuss their potential optimization based on the correspondence with RSV studies.
Long-Term Evaluation of a UK Community Pharmacy-Based Weight Management Service
Authors: Evans Gareth , Wright David
Published: February 2020

Obesity increases the risk of cardiovascular disease, type 2 diabetes and cancer, reducing both the quality and quantity of life. Consequently, government healthcare costs are significant. A greater than 5% reduction in weight has been shown to result in significant improvements in type II diabetes, blood pressure and cholesterol levels and therefore effective interventions are required. This paper reports the results from 17 years of delivering a private, individualised very low calorie diet (VLCD) programme in community pharmacy. In line with national guidelines, a community pharmacy-based private weight management service was set up to support individuals over the age of 18. After assessment for clinical suitability, individuals were offered either a flexible weight loss plan or a strict weight loss plan using a very low calorie diet (VLCD). The VLCD was delivered using the protocols of the proprietary programme, Lipotrim™. These individuals followed one or more dieting sequences, defined as at least one week of attendance whilst following the VLCD, without discontinuation, producing at least a start and end weight. Data were recorded weekly and audited for this report including weight and BMI on initial presentation, weight and BMI lost and % weight and BMI loss. A total of 1875 dieting sequences were recorded from 1023 dieters. In 1261 (67.3%) sequences, a medically beneficial weight loss of >5% was achieved. Overall, the cohort demonstrated mean (sd) % weight losses of 10.1% (7.7). Mean (sd) % weight losses seen in people with type 2 diabetes was 10.4% (2.7) and 10.6% (5.9) in hypertension. In total, 555 diet sequences accessed long-term weight maintenance support. In 173 (31%) of these cases, a second weight check post weight loss could not be made. The remaining 382 individuals presenting showed a mean (sd) weight gain of only 1.4 kg (4.3) equating to a mean (sd) % weight gain of only 1.8% (4.6) over a mean (sd) number of days post weight-loss of 132 days (179). The results from this long-term review demonstrate that with proper provision of a nutritionally complete VLCD, through private service provision, community pharmacies can make a significant contribution to reducing the obesity epidemic at no cost to state-funded health systems.
Comparative Proteomics of Root Apex and Root Elongation Zones Provides Insights into Molecular Mechanisms for Drought Stress and Recovery Adjustment in Switchgrass
Authors: Ye Zhujia , Sangireddy Sasikiran Reddy , Yu Chih-Li , Hui Dafeng , Howe Kevin , Fish Tara , Thannhauser Theodore W. , Zhou Suping
Published: February 2020

Switchgrass plants were grown in a Sandwich tube system to induce gradual drought stress by withholding watering. After 29 days, the leaf photosynthetic rate decreased significantly, compared to the control plants which were watered regularly. The drought-treated plants recovered to the same leaf water content after three days of re-watering. The root tip (1cm basal fragment, designated as RT1 hereafter) and the elongation/maturation zone (the next upper 1 cm tissue, designated as RT2 hereafter) tissues were collected at the 29th day of drought stress treatment, (named SDT for severe drought treated), after one (D1W) and three days (D3W) of re-watering. The tandem mass tags mass spectrometry-based quantitative proteomics analysis was performed to identify the proteomes, and drought-induced differentially accumulated proteins (DAPs). From RT1 tissues, 6156, 7687, and 7699 proteins were quantified, and 296, 535, and 384 DAPs were identified in the SDT, D1W, and D3W samples, respectively. From RT2 tissues, 7382, 7255, and 6883 proteins were quantified, and 393, 587, and 321 proteins DAPs were identified in the SDT, D1W, and D3W samples. Between RT1 and RT2 tissues, very few DAPs overlapped at SDT, but the number of such proteins increased during the recovery phase. A large number of hydrophilic proteins and stress-responsive proteins were induced during SDT and remained at a higher level during the recovery stages. A large number of DAPs in RT1 tissues maintained the same expression pattern throughout drought treatment and the recovery phases. The DAPs in RT1 tissues were classified in cell proliferation, mitotic cell division, and chromatin modification, and those in RT2 were placed in cell wall remodeling and cell expansion processes. This study provided information pertaining to root zone-specific proteome changes during drought and recover phases, which will allow us to select proteins (genes) as better defined targets for developing drought tolerant plants. The mass spectrometry proteomics data are available via ProteomeXchange with identifier PXD017441.
Delta Boosting Implementation of Negative Binomial Regression in Actuarial Pricing
Authors: Lee Simon CK
Published: February 2020

This study proposes an efficacious approach to analyze the over-dispersed insurance frequency data as it is imperative for the insurers to have decisive informative insights for precisely underwriting and pricing insurance products, retaining existing customer base and gaining an edge in the highly competitive retail insurance market. The delta boosting implementation of the negative binomial regression, both by one-parameter estimation and a novel two-parameter estimation, was tested on the empirical data. Accurate parameter estimation of the negative binomial regression is complicated with considerations of incomplete insurance exposures, negative convexity, and co-linearity. The issues mainly originate from the unique nature of insurance operations and the adoption of distribution outside the exponential family. We studied how the issues could significantly impact the quality of estimation. In addition to a novel approach to simultaneously estimate two parameters in regression through boosting, we further enrich the study by proposing an alteration of the base algorithm to address the problems. The algorithm was able to withstand the competition against popular regression methodologies in a real-life dataset. Common diagnostics were applied to compare the performance of the relevant candidates, leading to our conclusion to move from light-tail Poisson to negative binomial for over-dispersed data, from generalized linear model (GLM) to boosting for non-linear and interaction patterns, from one-parameter to two-parameter estimation to reflect more closely the reality.
Land Cover Changes in Open-Cast Mining Complexes Based on High-Resolution Remote Sensing Data
Authors: Nascimento Filipe Silveira , Gastauer Markus , Souza-Filho Pedro Walfir M. , Nascimento Wilson R. , Santos Diogo C. , Costa Marlene F.
Published: February 2020

Remote sensing technologies can play a fundamental role in the environmental assessment of open-cast mining and the accurate quantification of mine land rehabilitation efforts. Here, we developed a systematic geographic object-based image analysis (GEOBIA) approach to map the amount of revegetated area and quantify the land use changes in open-cast mines in the Carajás region in the eastern Amazon, Brazil. Based on high-resolution satellite images from 2011 to 2015 from different sensors (GeoEye, WorldView-3 and IKONOS), we quantified forests, cangas (natural metalliferous savanna ecosystems), mine land, revegetated areas and water bodies. Based on the GEOBIA approach, threshold values were established to discriminate land cover classes using spectral bands, the normalized difference vegetation index (NDVI), normalized difference water index (NDWI) and a light detection and range sensor (LiDAR) digital terrain model and slope map. The overall accuracy was higher than 90%, and the kappa indices varied between 0.82 and 0.88. During the observation period, the mining complex expanded, which led to the conversion of canga and forest vegetation to mine land. At the same time, the amount of revegetated area increased. Thus, we conclude that our approach is capable of providing consistent information regarding land cover changes in mines, with a special focus on the amount of revegetation necessary to fulfill environmental liabilities.
Consistency of Radiometric Satellite Data over Lakes and Coastal Waters with Local Field Measurements
Authors: Alikas Krista , Ansko Ilmar , Vabson Viktor , Ansper Ave , Kangro Kersti , Uudeberg Kristi , Ligi Martin
Published: February 2020

The Sentinel-3 mission launched its first satellite Sentinel-3A in 2016 to be followed by Sentinel-3B and Sentinel-3C to provide long-term operational measurements over Earth. Sentinel-3A and 3B are in full operational status, allowing global coverage in less than two days, usable to monitor optical water quality and provide data for environmental studies. However, due to limited ground truth data, the product quality has not yet been analyzed in detail with the fiducial reference measurement (FRM) dataset. Here, we use the fully characterized ground truth FRM dataset for validating Sentinel-3A Ocean and Land Colour Instrument (OLCI) radiometric products over optically complex Estonian inland waters and Baltic Sea coastal areas. As consistency between satellite and local data depends on uncertainty in field measurements, filtering of the in situ data has been made based on the uncertainty for the final comparison. We have compared various atmospheric correction methods and found POLYMER (POLYnomial-based algorithm applied to MERIS) to be most suitable for optically complex waters under study in terms of product accuracy, amount of usable data and also being least influenced by the adjacency effect.
A New Approach of the Global Navigation Satellite System Tomography for Any Size of GNSS Network
Authors: Wang Yuchen , Ding Nan , Zhang Yu , Li Long , Yang Xiaoyan , Zhao Qingzhi
Published: February 2020

Global Navigation Satellite System (GNSS) tomography is a popular method for measuring and modelling water vapor in the troposphere. Presently, most studies use a cuboid-shaped tomographic region in their modelling, which represents the modelling region for all measurement epochs. This region is defined by the distribution of the GNSS signals skywards from a network of ground based GNSS stations for all epochs of measurements. However, in reality at each epoch the shape of the GNSS tomographic region is more likely to be an inverted cone. Unfortunately, this fixed conic tomographic region does not properly reflect the fact that the GNSS signal changes quickly over time. Therefore a dynamic or adaptive tomographic region is better suited. In this study, a new approach that adjusts the GNSS tomographic model to adapt the size of the GNSS network is proposed, which referred to as The High Flexibility GNSS Tomography (HFGT). Test data from different numbers of the GNSS stations are used and the results from HFGT are compared against that of radiosonde data (RS) to assess the accuracy of the HFGT approach. The results showed that the new approach is feasible for different numbers of the GNSS stations when a sufficient and uniformed distribution of GNSS signals is used. This is a novel approach for GNSS tomography.
Synthesizing Remote Sensing and Biophysical Measures to Evaluate Human–wildlife Conflicts: The Case of Wild Boar Crop Raiding in Rural China
Authors: Giefer Madeline , An Li
Published: February 2020

Crop raiding by wild boars is a growing problem worldwide with potentially damaging consequences for rural dwellers’ cooperation with conservation policies. Still, limited resources inhibit continuous monitoring, and there is uncertainty about the relationship between the biophysical realities of crop raiding and humans’ perceptions and responses. By integrating data from camera traps, remote sensors, and household surveys, this study establishes an empirical model of wild boar population density that can be applied to multiple years to estimate changes in distribution over time. It also correlates historical estimates of boar population distribution with human-reported trends to support the model’s validity and assess local perceptions of crop raiding. Although the model proved useful in coniferous and bamboo forests, it is less useful in mixed broadleaf, evergreen broadleaf, and deciduous forests. Results also show alignment between perceptions of crop raiding and actual boar populations, corroborating farmers’ perceptions which are increasingly dismissed as a less reliable source of information in human–wildlife conflict research. The modeling techniques demonstrated here may provide conservation practitioners with a cost-effective way to maintain up-to-date estimates of the spatial distribution of wild boar and resultant crop raiding.
Patterns of Historical and Future Urban Expansion in Nepal
Authors: Rimal Bhagawat , Sloan Sean , Keshtkar Hamidreza , Sharma Roshan , Rijal Sushila , Shrestha Uttam Babu
Published: February 2020

Globally, urbanization is increasing at an unprecedented rate at the cost of agricultural and forested lands in peri-urban areas fringing larger cities. Such land-cover change generally entails negative implications for societal and environmental sustainability, particularly in South Asia, where high demographic growth and poor land-use planning combine. Analyzing historical land-use change and predicting the future trends concerning urban expansion may support more effective land-use planning and sustainable outcomes. For Nepal’s Tarai region—a populous area experiencing land-use change due to urbanization and other factors—we draw on Landsat satellite imagery to analyze historical land-use change focusing on urban expansion during 1989–2016 and predict urban expansion by 2026 and 2036 using artificial neural network (ANN) and Markov chain (MC) spatial models based on historical trends. Urban cover quadrupled since 1989, expanding by 256 km2 (460%), largely as small scattered settlements. This expansion was almost entirely at the expense of agricultural conversion (249 km2). After 2016, urban expansion is predicted to increase linearly by a further 199 km2 by 2026 and by another 165 km2 by 2036, almost all at the expense of agricultural cover. Such unplanned loss of prime agricultural lands in Nepal’s fertile Tarai region is of serious concern for food-insecure countries like Nepal.
Modelling and Terrestrial Laser Scanning Methodology (2009–2018) on Debris Cones in Temperate High Mountains
Authors: de Sanjosé-Blasco José Juan , López-González Mariló , Alonso-Pérez Estrella , Serrano Enrique
Published: February 2020

Debris cones are a very common landform in temperate high mountains. They are the most representative examples of the periglacial and nival processes. This work studies the dynamic behavior of two debris cones (Cone A and Cone B) in the Picos de Europa, in the north of the Iberian Peninsula. Their evolution was measured uninterruptedly throughout each August for 10 years (2009–2018) using the Terrestrial Laser Scanning (TLS) technique. The observations and calculations of the two debris cones were treated independently, but both showed the same behavior. Therefore, if these results are extrapolated to other debris cones in similar environments (temperate high mountain), they should show behavior similar to that of the two debris cones analyzed. Material falls onto the cones from the walls, and transfer of sediments follows linear trajectories according to the maximum slope. In order to understand the linear evolution of the two debris cones, profiles were created along the maximum slope lines of the Digital Elevation Model (DEM) of 2009, and these profile lines were extrapolated to the remaining years of measurement. In order to determine volumetric surface behavior in the DEMs, each year for the period 2009–2018 was compared. In addition, the statistical predictive value for position (Z) in year 2018 was calculated for the same planimetric position (X,Y) throughout the profiles of maximum slopes. To do so, the real field data from 2009–2017 were interpolated and used to form a sample of curves. These curves are interpreted as the realization of a functional random variable that can be predicted using statistical techniques. The predictive curve obtained was compared with the 2018 field data. The results of both coordinates (Z), the real field data, and the statistical data are coherent within the margin of error of the data collection.
Robust Motion Control for UAV in Dynamic Uncertain Environments Using Deep Reinforcement Learning
Authors: Wan Kaifang , Gao Xiaoguang , Hu Zijian , Wu Gaofeng
Published: February 2020

In this paper, a novel deep reinforcement learning (DRL) method, and robust deep deterministic policy gradient (Robust-DDPG), is proposed for developing a controller that allows robust flying of an unmanned aerial vehicle (UAV) in dynamic uncertain environments. This technique is applicable in many fields, such as penetration and remote surveillance. The learning-based controller is constructed with an actor-critic framework, and can perform a dual-channel continuous control (roll and speed) of the UAV. To overcome the fragility and volatility of original DDPG, three critical learning tricks are introduced in Robust-DDPG: (1) Delayed-learning trick, providing stable learnings, while facing dynamic environments; (2) adversarial attack trick, improving policy’s adaptability to uncertain environments; (3) mixed exploration trick, enabling faster convergence of the model. The training experiments show great improvement in its convergence speed, convergence effect, and stability. The exploiting experiments demonstrate high efficiency in providing the UAV a shorter and smoother path. While, the generalization experiments verify its better adaptability to complicated, dynamic and uncertain environments, comparing to Deep Q Network (DQN) and DDPG algorithms.
Lightweight Integrated Solution for a UAV-Borne Hyperspectral Imaging System
Authors: Zhang Hao , Zhang Bing , Wei Zhiqi , Wang Chenze , Huang Qiao
Published: February 2020

The rapid development of unmanned aerial vehicles (UAVs), miniature hyperspectral imagers, and relevant instruments has facilitated the transition of UAV-borne hyperspectral imaging systems from concept to reality. Given the merits and demerits of existing similar UAV hyperspectral systems, we presented a lightweight, integrated solution for hyperspectral imaging systems including a data acquisition and processing unit. A pushbroom hyperspectral imager was selected owing to its superior radiometric performance. The imager was combined with a stabilizing gimbal and global-positioning system combined with an inertial measurement unit (GPS/IMU) system to form the image acquisition system. The postprocessing software included the radiance transform, surface reflectance computation, geometric referencing, and mosaic functions. The geometric distortion of the image was further significantly decreased by a postgeometric referencing software unit; this used an improved method suitable for UAV pushbroom images and showed more robust performance when compared with current methods. Two typical experiments, one of which included the case in which the stabilizing gimbal failed to function, demonstrated the stable performance of the acquisition system and data processing system. The result shows that the relative georectification accuracy of images between the adjacent flight lines was on the order of 0.7–1.5 m and 2.7–13.1 m for cases with spatial resolutions of 5.5 cm and 32.4 cm, respectively.