bluuebunny/crossref_metadata_2025 huggingface dataset:
ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion
Authors: Lang Lei , Hou Yixuan , Chen Yanlin , Tu Gang , Tao Jing , Yang Dan , Xi Lei , Fu Lixin , Sun Kexin , Yin Jiali , Chen Rui , Peng Meixi , Liu Shuiqing , Liu Manran
Published: December 2018

Background/Aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and acts as tumor suppressor. Although evidence shows that a DNA damage-independent ATM (oxidized ATM) may be involved in cancer progression, the underlying mechanism is still unclear. Methods: Immunohistochemistry, immunofluorescence and western blotting were applied to detect the levels of oxidized ATM. Transwell assay was used to detect the cell migration and invasion abilities in different treatments. Quantitative phosphoproteome analysis was performed using hypoxic BT549 cells, in the presence or absence of Ku60019, a specific inhibitor of ATM kinase. The phosphorylated cortactin, the target protein of oxidized ATM, was confirmed by immunoprecipitation-western blots and in vitro kinase assay. The functions of phosphorylated cortactin were studied by specific short hairpin RNA, site-directed mutation, transwell assay, and actin polymerization assay. Results: Enhanced oxidized ATM proteins were present not only in the advanced and invasive breast tumor tissues but also malignant hypoxic breast cancer cells, in the absence of DNA damage. Loss of ATM expression or inhibiting oxidized ATM kinase activity reduced breast cancer cell migration and invasion. Using quantitative phosphoproteomics approach, 333 oxidized ATM target proteins were identified, some of these proteins govern key signaling associated with gap junction, focal adhesion, actin cytoskeleton rearrangement. Cortactin, one of the biggest changed phospho-protein, is a novel oxidized ATM-dependent target in response to hypoxia. Mechanically, we reveal that hypoxia-activated ATM can enhance the binding affinity of cortactin with Arp2/3 complex by phosphorylating cortactin at serine 113, and as a result, in favor of breast cancer cell migration and invasion. Conclusion: Oxidized ATM can phosphorylate cortactin at serine 113, playing a critical role in promoting breast tumor cell mobility and invasion via actin polymerization.
Redescription of tadpole of the hylodid frog Hylodes asper (Müller, 1924)
Authors: COSTA PAULO NOGUEIRA , SILVA-SOARES THIAGO , WEBER LUIZ NORBERTO , DE CARVALHO-E-SILVA ANA MARIA PAULINO TELLES
Published: December 2018

The genus Hylodes Fitzinger, 1826 currently comprises 24 species of diurnal frogs (Frost 2010), most of them restricted to mountainous rheophilic habitats of the Brazilian Atlantic Forest Biome ((Nascimento et al. 2001), with exception for Hylodes otavioi, inhabitant of the rocky fields from the riparian forests at the Serra do Cipó (Sazima & Bokermann 1982).
A polychromatic new species of Apiomerus (Hemiptera: Reduviidae: Harpactorinae) from Central America
Authors: FORERO DIMITRI , BERNIKER LILY , SZERLIP SIGURD
Published: December 2018

Apiomerus barrocoloradoi sp. nov. is described from Costa Rica and Panama. This new species is highly polychromatic, a judgment based on specimens of the same locality. Dorsal habitus images documenting the range of variation of the color pattern are provided. Male and female genitalia are documented in detail to provide unambiguous characters for species recognition. Color variation is discussed with regard to traditional species limits.
A new fossil genus of Mesochrysopidae (Neuroptera) from the Early Cretaceous Yixian Formation of China
Authors: REN DONG , MAKARKIN VLADIMIR N. , YANG QIANG
Published: December 2018

Longicellochrysa yixiana gen. et sp. nov. (Neuroptera: Mesochrysopidae) is described from the Mesozoic Yixian Formation (China). Allopteridae and Tachinymphidae of Nel et al. (2005) are considered subfamilies of Mesochrysopidae, along with Mesochrysopinae. Longicellochrysa gen. nov. displays a mixture of character states of Mesochrysopinae and Allopterinae and can not be assigned to any subfamily, indirectly supporting a family status of Mesochrysopidae sensu lato.
A review of burrower bugs (Hemiptera: Heteroptera: Cydnidae sensu lato) of Guam
Authors: LIS JERZY A. , ZACK RICHARD S.
Published: December 2018

Five species representing the family Cydnidae sensu lato are recorded from Guam; three of them are reported for the first time from the island: Byrsinus varians (Fabricius, 1803), Fromundus biimpressus (Horváth, 1919), and Rhytidoporus indentatus Uhler, 1877. The widespread species, Fromundus pygmaeus (Dallas), was recorded by Ruckes (1963) and verified by us. The occurrence of a fifth species, previously listed from the island by Ruckes (1963) and Lis (1996), namely Adrisa flavomarginata (Vollenhoven, 1868), is regarded as doubtful. Of four currently known burrower bug species occurring on Guam, three are Oriental and one is American in origin. A key to all burrower bug species known from the island is provided. Additionally, Microporus shiromai Froeschner, 1976 from Hawaii is regarded as a junior synonym of Byrsinus varians (Fabricius, 1803).
A new species of the Genus Anchocerus Fauvel, 1905 from China (Coleoptera: Staphylinidae: Staphylininae)
Authors: HU JIAYAO , LI LIZHEN , ZHAO YUNLONG
Published: December 2018

Anchocerus Fauvel, 1905 is a small genus of the rove beetle tribe Staphylinini. The most recent diagnoses of this genus were provided in Smetana (1988) and Solodovnikov (2008). Until now, 13 species of Anchocerus have been known in the world fauna. Among them, only two species were known from China: A. shibatai Smetana (1995) from Taiwan and A. schuelkei Smetana (2005) from Sichuan and Yunnan Provinces. In addition, one unnamed species of uncertain identity was mentioned by Smetana (2005) from Fujian Province.
Molecular analysis of Acanthemblemaria macrospilus (Teleostei: Chaenopsidae) with description of a new species from the Gulf of California, Mexico
Authors: LIN HSIU-CHIN , GALLAND GRANTLY R.
Published: December 2018

Molecular analysis of the chaenopsid tube blenny, Acanthemblemaria macrospilus Brock, reveals species-level differentiation and the existence of a new species, described here as Acanthemblemaria hastingsi, using molecular and morphological data. This new species is a member of the hancocki species group and is limited to the Gulf of California. It is distinguishable from A. macrospilus by mitochondrial gene sequences of cytochrome C oxidase I and D-loop region as well as by coloration. This differentiation is also supported to a lesser extent by the nuclear ribosomal protein S7 first intron. There is no geographic overlap in the ranges of these species, as they occur exclusively on either side of the Sinaloan Gap.
Bloszykiella africana gen. nov., sp. nov., a new mite genus from East Africa (Acari: Mesostigmata: Uropodidae)
Authors: KONTSCHÁN JENŐ
Published: December 2018

A new monotypic genus, Bloszykiella africana gen. nov., sp. nov. (Mesostigmata: Uropodina: Uropodidae) is described on the basis of two females and one deutonymph found in soil samples from Tanzania. The new genus is unusual among Uropodina in having large strongly dentate chelicerae.
A study of some species of the genus Stictococcus Cockerell (Hemiptera: Sternorrhyncha: Coccoidea: Stictococcidae), and a discussion on Stictococcus vayssierei Richard, a species injurious to cassava in Equatorial Africa with adescription of a new species from Nigeria
Authors: WILLIAMS DOUGLAS J. , MATILE-FERRERO DANIÈLE , MILLER DOUGLASS R.
Published: December 2018

The adult female of the scale insect Stictococcus vayssierei Richard is described and illustrated. The species feeds on the root system of cassava (Manihot esculenta) (Euphorbiaceae) in Equatorial Africa, affecting tuber formation of the plant. Although damage has been reported only recently, the species has probably remained unnoticed because of its subterranean habit. The distribution and host plants of this species are listed and the segmentation of the adult female of Stictococcus is discussed to help describe the characters in detail when specimens are prepared on microscope slides. Six other species of Stictococcus are described or discussed: S. formicarius Newstead, S. intermedius Newstead, S. pujoli Richard, S. sjostedti Cockerell & Cockerell, S. subterreus Williams, Matile-Ferrero & Miller sp. n., and S. formicarius var. tuberculata Laing which is here raised to specific rank as S. tuberculatus Laing.
The Inocellia crassicornis species group (Raphidioptera: Inocelliidae) in mainland China, with description of two new species
Authors: LIU XINGYUE , ASPöCK HORST , YANG DING , ASPÖCK ULRIKE
Published: December 2018

Snakeflies of the Inocellia crassicornis species group from mainland China are revised. Two new species are described: Inocellia biprocessus sp. nov. and Inocellia digitiformis sp. nov. A key is provided for the males of all the species of the I. crassicornis group.
Notes concerning the genus Metataenia Théry, 1923 (Coleoptera, Buprestidae, Chrysochroina) from Papua New Guinea, with description of a new species and designation of a lectotype
Authors: NYLANDER ULF
Published: December 2018

Metataenia hauseri Obenberger, 1928 is redescribed from specimens from Popondetta in eastern Papua New Guinea and compared with M. loriae Kerremans, 1895. Metataenia hudsoni sp. nov. is described from Misima Island in the Louisiade Archipelago of southeastern Papua New Guinea and compared with M. capitata Kerremans, 1903 from Rossel Island. Metataenia rothschildi Théry, 1923 is redescribed from the second known specimen. A lectotype is designated for M. capitata.
A review of Japanese species of the genus Montandoniola (Hemiptera: Heteroptera: Anthocoridae)
Authors: YAMADA KAZUTAKA , YASUNAGA TOMOHIDE , MIYAMOTO SYÔITI
Published: December 2018

The flower bug genus Montandoniola Poppius, 1909 of Japan, which previously was represented by a single species, is herein reviewed. Three species are recognized. A new species, M. kerzhneri sp. nov., is described from Iriomote Island of the Ryukyus. Montandoniola thripodes Bergroth, 1916 is recorded from Japan for the first time. Montandoniola thripodes and M. pictipennis (Esaki, 1931) are diagnosed, with detailed descriptions and illustrations of the male and female genitalia. Digital images of the habitus and external characters are provided for all species. Biological notes on M. thripodes and M. pictipennis and a key to the Japanese species are also given.
Cameronaptera glabrinotum n.gen., n.sp. from Malaysia(Hemiptera: Heteroptera: Aradidae)
Authors: HEISS E.
Published: December 2018

A new genus of apterous Carventinae from the Malaysian mainland, Cameronaptera n. gen. with the species glabrinotum n.sp., is described and figured. Because of its habitus and abdominal structures, it is not related to any other Oriental Carventinae.
The need for standard protocols in bioregionalisation: Comments on “The spectre of biogeographical regionalization” by Morrone (2018)
Authors: UNG VISOTHEARY
Published: December 2018

Morrone (2018) provided a general protocol to undertake biogeographical regionalizations consisting in seven steps, namely 1. defining the study area, 2. assembling distributional data, 3. identifying natural areas, 4. discovering area relationships, 5. defining boundaries/transition zones, 6. regionalization and, 7. area nomenclature. This protocol is aimed at facilitating communication between cross-domain researchers and contributing to the development of a truly integrative biogeography. Here I would like to discuss some ideas raised by Morrone (2018) and show that comparative biogeographical methods (sensu Parenti and Ebach 2009) are based on a cladistic rationale which provides the ontological framework to address this issue i.e. initiate biogeographical regionalizations leading to an integrative biogeography. This kind of standardisation has already been used in different context of biogeographical analysis and highlighted interesting results (Hoagstrom et al., 2014; Ung et al., 2016, 2017).
Paraneseuthia Franz of Japan: two new species and rediscovery of the enigmatic P. holzneri Franz (Coleoptera, Staphylinidae, Scydmaeninae)
Authors: JAŁOSZYŃSKI PAWEŁ
Published: December 2018

To date, three nominal species of the eutheiine genus Paraneseuthia were known to occur in Japan (in Honshū and Kyūshū). A female of an undescribed species was also recorded from Iriomote Island of the Ryūkyū Archipelago. Two new species are here added to this list: P. ishigakianas p. n. (Ishigaki Is.) and P. ehimensis sp. n. (Shikoku). Paraneseuthia holzneri (Franz), described on the basis of a single male with erected and distorted aedeagus, is recorded from a new locality and its aedeagus is illustrated.
Ensemble Sensitivity Analysis of the Blocking System over Russia in Summer 2010
Authors: Quandt Lisa-Ann , Keller Julia H. , Martius Olivia , Pinto Joaquim G. , Jones Sarah C.
Published: December 2018

In summer 2010, the weather conditions in the Euro-Russian sector were affected by a long-lasting atmospheric block that led to a heat wave in Russia and floods in Pakistan. Following previous studies describing the block’s predictability, the present study aims to investigate uncertainties in the upper-level wave pattern and diabatic processes that were responsible for the block’s forecast variability during its onset, mature, and decay phases. With this aim, an ensemble sensitivity analysis (ESA) is performed for three medium-range THORPEX Interactive Grand Global Ensemble multimodel ensemble forecasts, one associated with each phase of the block’s life cycle. The ESA revealed that the block’s predictability was influenced by forecast uncertainties in the general wave pattern and in the vertically integrated water vapor transport (IVT), used here as a proxy for diabatic processes. These uncertainties are associated with spatial shifts and intensity changes of synoptic waves and IVT during the whole life cycle of the block. During the onset phase, specific features include an Atlantic precursor block and the occurrence of several cyclones. During the mature stage, the blocking ridge itself was highly predictable, while forecast uncertainties in the wave pattern and in IVT primarily were associated with uncertainties in the block’s western flank. During the decay phase, the ESA signals were less intense, but the forecast variability significantly depended on the transformation of the block into a high-over-low pattern. It can be concluded that ESA is suitable to investigate the block’s forecast variability in multimodel ensembles.
The Paradox of Administrative Decentralization Reform in Young Asian Democracies:South Korea and Indonesia
Authors: Heo Inhye
Published: December 2018

It is generally perceived that administrative decentralization reform in young democracies is a promise to improve democracy from below. Yet, in terms of democratic development, the impact of this process is ambivalent, and can be described as a paradox of reform. This article argues that preemptive countermeasures that offset problems predicted to emerge as the reform proceeds should be formulated as part of the reform through introducing a preventive policy paradigm in the area of democratic reform policy. This is to alleviate or prevent the creation of the paradox and to contribute to democratic development through enhancing people’s satisfaction with the newly democratized government. To this end, this study examines administrative decentralization reform in South Korea and Indonesia and uncovers these reforms’ paradoxes. These two cases are particularly worthy of study, since their young democratic governments lack countermeasures against predictable reform problems, intensifying the paradox. I argue that the implications drawn from these two cases for methods of enhancing democratic development in other young democracies are worth heeding.
Prediction of Atypical Ductal Hyperplasia Upgrades Through a Machine Learning Approach to Reduce Unnecessary Surgical Excisions
Authors: Harrington Lia , diFlorio-Alexander Roberta , Trinh Katherine , MacKenzie Todd , Suriawinata Arief , Hassanpour Saeed
Published: December 2018

Purpose

Surgical excision is currently recommended for all occurrences of atypical ductal hyperplasia (ADH) found on core needle biopsies for malignancy diagnoses and treatment of lesions. The excision of all ADH lesions may lead to overtreatment, which results in invasive surgeries for benign lesions in many women. A machine learning method to predict ADH upgrade may help clinicians and patients decide whether combined active surveillance and hormonal therapy is a reasonable alternative to surgical excision.

Methods

The following six machine learning models were developed to predict ADH upgrade from core needle biopsy: gradient-boosting trees, random forest, radial support vector machine (SVM), weighted K-nearest neighbors (KNN), logistic elastic net, and logistic regression. The study cohort consisted of 128 lesions from 124 women at a tertiary academic care center in New Hampshire who had ADH on core needle biopsy and who underwent an associated surgical excision from 2011 to 2017.

Results

The best-performing models were gradient-boosting trees (area under the curve [AUC], 68%; accuracy, 78%) and random forest (AUC, 67%; accuracy, 77%). The top five most important features that determined ADH upgrade were age at biopsy, lesion size, number of biopsies, needle gauge, and personal and family history of breast cancer. Using the random forest model, 98% of all malignancies would have been diagnosed through surgical biopsies, whereas 16% of unnecessary surgeries on benign lesions could have been avoided (ie, 87% sensitivity at 45% specificity).

Conclusion

These results add to the growing body of support for machine learning models as useful aids for clinicians and patients in decisions about the clinical management of ADH.
Use and Patient-Reported Outcomes of Clinical Multigene Panel Testing for Cancer Susceptibility in the Multicenter Communication of Genetic Test Results by Telephone Study
Authors: Hall Michael J. , Patrick-Miller Linda J. , Egleston Brian L. , Domchek Susan M. , Daly Mary B. , Ganschow Pamela , Grana Generosa , Olopade Olufunmilayo I. , Fetzer Dominique , Brandt Amanda , Chambers Rachelle , Clark Dana F. , Forman Andrea , Gaber Rikki , Gulden Cassandra , Horte Janice , Long Jessica M. , Lucas Terra , Madaan Shreshtha , Mattie Kristin , McKenna Danielle , Montgomery Susan , Nielsen Sarah , Powers Jacquelyn , Rainey Kim , Rybak Christina , Savage Michelle , Seelaus Christina , Stoll Jessica , Stopfer Jill E. , Yao Xinxin (Shirley) , Bradbury Angela R.
Published: December 2018

Purpose

Multigene panels (MGPs) are increasingly being used despite questions regarding their clinical utility and no standard approach to genetic counseling. How frequently genetic providers use MGP testing and how patient-reported outcomes (PROs) differ from targeted testing (eg, BRCA1/2 only) are unknown.

Methods

We evaluated use of MGP testing and PROs in participants undergoing cancer genetic testing in the multicenter Communication of Genetic Test Results by Telephone study (ClinicalTrials.gov identifier: NCT01736345), a randomized study of telephone versus in-person disclosure of genetic test results. PROs included genetic knowledge, general and state anxiety, depression, cancer-specific distress, uncertainty, and satisfaction. Genetic providers offered targeted or MGP testing based on clinical assessment.

Results

Since the inclusion of MGP testing in 2014, 395 patients (66%) were offered MGP testing. MGP testing increased over time from 57% in 2014 to 66% in 2015 ( P = .02) and varied by site (46% to 78%; P < .01). Being offered MGP testing was significantly associated with not having Ashkenazi Jewish ancestry, having a history of cancer, not having a mutation in the family, not having made a treatment decision, and study site. After demographic adjustment, patients offered MGP testing had lower general anxiety ( P = .04), state anxiety ( P = .03), depression ( P = .04), and uncertainty ( P = .05) pre-disclosure compared with patients offered targeted testing. State anxiety ( P = .05) and cancer-specific distress ( P = .05) were lower at disclosure in the MGP group. There was a greater increase in change in uncertainty ( P = .04) among patients who underwent MGP testing.

Conclusion

MGP testing was more frequently offered to patients with lower anxiety, depression, and uncertainty and was associated with favorable outcomes, with the exception of a greater increase in uncertainty compared with patients who had targeted testing. Addressing uncertainty may be important as MGP testing is increasingly adopted.
Boa administração: um direito fundamental a ser efetivado em prol de uma gestão pública eficiente
Authors: Ismail Filho Salomão
Published: December 2018

Good administration: fundamental right to be implemented in favor of efficient public management O direito administrativo moderno encontra-se intrinsecamente relacionado com o direito constitucional. Uma consequência de tal relação é o direito fundamental a uma boa administração. O conceito de boa governança, de caráter mais amplo e multidisciplinar, e o princípio da eficiência auxiliam na definição daquilo que seja uma boa administração no serviço público. É dever do gestor público/decisor político atender aos objetivos fundamentais da Constituição por meio de uma administração que concilie os custos orçamentários com os interesses e necessidades do administrado, ou seja, a pessoa humana, razão de ser do Estado. Modern administrative law is intrinsically related to constitutional law. One consequence would be the so-called fundamental right to good administration. The concept of good governance, broader and multidisciplinary, and the principle of efficiency help in the definition of what good administration is in the public service. The public and political manager has the duty to comply the fundamental objectives of Constitution through a management that reconciles the budget costs with interests and needs of the administered, that is, the human person, reason for existence of the State.
Morave Mt Oligocene-Middle Miocene succession of Albanian-Thessalian Basin
Authors: Pashko Pandeli
Published: December 2018

The Morava Mountain Oligocene-Middle Miocene molasse deposits take part in the Albanian-Thessalian Basin, which developed NW-SE from eastern Albania to Thessaly in Greece, where it is called as Mesohellenic Basin. The 4.5 km thick basin infill is subdivided into three molasse cycles separated by two regional unconformities at the Eocene/Oligocene and Aquitanian/Burdigalian boundaries. The Morava Mountain Oligocene-Middle Miocene molase, ~ 3500 m thick, represents an exposed continuous, rich in fossil fauna succession. Six stratigraphic sections were studied and measured.
Obsidian in the prehistoric Aegean: Trade and uses
Authors: Tsampiri Mailinta
Published: December 2018

This paper studies the prehistoric use of obsidian quarries in the Aegean. Obsidian sources in the eastern Mediterranean have been traced on certain islands of the Aegean: Melos, Antiparos and Giali. Due to its hardness, this material was already being used by the end of the Upper Palaeolithic to produce blades with sharp edges to serve as knives, scrapers and razors, arrowheads and spears, axes, saws and mattocks. This naturally occurring glass was also used for ornamental purposes. During the Late and the Final Neolithic Period (ca. 5300-3200 B.C.), when the systematic habitation of the Cyclades developed, the transportation of obsidian was incorporated in the gradually developing trade networks of the Aegean. The material was much in demand in the early Bronze Age. During the later Bronze Age its use declined and by the classical period it seems to have been replaced by metal. Around 1100 B.C. the use of obsidian was discontinued because of the increasing popularity of metals. During the Roman period obsidian, was used in the manufacture of mosaics and decorative objects, such as mirrors
Underground quarries in the area of Agiades, Samos Island, Greece: Notes on historical topography and chronology
Authors: Tziligkaki Eleni , Stamatakis Michael
Published: December 2018

This paper shows the need for cataloguing and comparing tool marks left on the quarries’ front in order for the chronological sequence of the different phases of limestone exposed in underground quarries at Agiades, Chora Samos, to be assessed. Up to now, an archaic and a roman phase of exploitation is inferred by surface pottery, tools, tool marks, the monuments themselves, and parallels from underground quarries on the island of Crete. The proximity of the quarries to a temenos of Apollo and the Nymphs is comparable to other cases from the Greek world. In an attempt to understand the social status of the quarrymen and their level of literacy, data from the graffiti observed in Eupalinos’ tunnel were correlated with the lack of patronym and ethnonym observed in quarries in the Aegean, and related to the characterization of the Samians as «πολυγράμματοι». A control of Hera’s sanctuary over the quarries at Agiades is implied by the frequent appearance of the letters HP on slabs used in Eupalinos’ tunnel.
Representation of the mother's image in the Russian mentality
Authors: Васягина Наталия , Vasyagina Nataliya , Газизова Юлия , Gazizova Yuliya
Published: December 2018

The monograph reveals the idea of representation of images as a system-structural basis for the construction of mentality, substantiates the special position of the image of the mother in the hierarchical system of the figurative sphere of man, supplemented by ideas about its dynamics in the Russian mentality. The image of the mother is considered as a complex mental phenomenon, which is represented in the consciousness of the projection of value-semantic and qualitative characteristics of maternal behavior and perception of the world, presented at the perceptual, conceptual and amodal levels hierarchically given reflection system. The article presents the results of the study of the content of the image of the mother, the gender and age features of reflection, described the "socially oriented" and "family-oriented" model of representation of the image of the mother in the Russian mentality.
The book will be useful to researchers and practitioners interested in the problems of family psychology, motherhood and childhood, teachers, graduate students, students of psychological and pedagogical specialties.
Traction electrical systems for motor vehicles
Authors: Овсянников Евгений , Ovsyannikov Evgeniy , Фомин Александр , Fomin Aleksandr
Published: December 2018

The textbook deals with traction electrical systems of various vehicles. Much attention is paid to the problems of energy supply of the main types of electric vehicles. The combined power plants based on internal combustion engines, electrochemical generators and solar batteries are considered. Traction electrical drives based on accepted BLDC and induction motors are widely used in modern mass-produced electric vehicles.
Meets the requirements of the Federal state educational standard of higher education of the last generation.
For University students enrolled in the field of training 23.03.02 " Ground transport and technological complexes." It can be useful for engineers and researchers involved in electric and hybrid vehicles.
Materials science in machine tool industry
Authors: Адаскин Анатолий , Adaskin Anatoliy
Published: December 2018

The textbook defines the main task of materials science in the machine tool industry-is the choice of materials and technologies that determine the accuracy of the machine. Structural materials for the manufacture of machine parts, materials of cutting, auxiliary tools and parts of devices are considered. These are the materials of parts of the system "machine-tool-tool-part" - AIDS system, which determines the rigidity of the machine and the accuracy of processing.
Possible causes and mechanisms of loss of accuracy and efficiency of the machine are shown: wear and spontaneous change in the size of parts over time, fatigue failure.
The principles and recommendations of the choice of materials of steel and cast iron metal – intensive parts and parts of the counter-bodies of sliding and rolling friction pairs, as well as reinforcing and stabilizing processing technologies that ensure the preservation of long-term accuracy of the machine are given.
The Appendix contains recommendations on the selection of tool materials for different operating conditions of mills and tools; materials of friction pairs; routing technology for manufacturing precision machine parts.
The textbook is intended for bachelors and masters studying in the specialties 15.00 "mechanical engineering", 22.00 "technology of materials" can be used in the training of graduate students of machine – building specialties and to improve the skills of design engineers and technologists of machine-building plants, primarily machine-tool enterprises.
Acute asthma attacks in the school setting: Diagnosis, management and prevention
Authors: Bostock-Cox Beverley
Published: December 2018

Poor treatment adherence and technique in the management of asthma, along with exposure to triggers, may lead to an asthma attack. In order to manage an asthma attack correctly, an initial assessment should be carried out along with the swift administration of bronchodilators via a pMDI and spacer. Depending on the response, the child should then be seen in general practice to be assessed and to get a prescription for oral steroids. Follow-up should be arranged to assess the reasons for the acute attack and to review the PAAP. If the child is suffering from life-threatening asthma, immediate hospital admission via a 999 call should be arranged. This article provides an overview of the signs and symptoms, and management of an asthma attack, as well as advice on prevention.
Newly qualified health visitor: The health visitor role in strengthening community capacity
Authors: Bewick Jessica
Published: December 2018

The transition between leaving one community and starting in another has triggered reflection on my role as a community practitioner
Development of a breastfeeding training model in the north east of England
Authors: Menzies Jennifer
Published: December 2018

Many policy drivers have identified the importance of peer support for breastfeeding, and recent reviews have recognised that support for breastfeeding mothers can help to increase breastfeeding rates and in turn reduce health and social inequalities. Breastfeeding peer support groups offer much more to a community than is measureable in terms of money. Deprived areas of the UK are seen as having ‘lost skills’ in breastfeeding; they have no experience or tradition of breastfeeding to draw on and are unable to view it as an everyday activity that influences an intention to breastfeed and leads to bottle feeding. South Tyneside is one of the most deprived areas in the UK, and has integrated and implemented peer counsellor training into the support model for new mothers and the training model with other professionals. It has had a high success rate with more than a fifth moving on to nurse education.
Authors: Rill Róbert Adrian , Faragó Kinga Bettina
Published: December 2018

In this work we investigate the effects of switching from mouse cursor control to gaze-based control in a computerized divided attention game. We conducted experiments with nine participants performing a task that requires continuous focused concentration and frequent shifts of attention. Despite carefully controlling experimental and design aspects, the performance of subjects was considerably impaired when using gaze-based control. The participants were experienced users of the mouse control version of the task, we adjusted the difficulty to the more demanding conditions and selected the parameters of gaze input based on previous research findings. In contrast to our assumptions, experienced users could not get used to gaze-based control in the amount of experiments we performed. Additionally we consider the strategies of users, i.e. their method of problem solving, and found that it is possible to make progress in our task even during a short amount of practice. The results of this study provide evidence that the adoption of interfaces controlled by human eye-gaze in cognitively demanding environments require careful design, proper testing and sufficient user training.
Strategi Komunikasi Publik Dalam Membangun Pemahaman Mahasiswa Terhadap Penerapan PTNBH
Authors: Zubair Feliza , Dewi Retasari , Kadarisman Ade
Published: December 2018

Penelitian ini bertujuan untuk menganalisis strategi komunikasi publik yang dilakukan oleh Humas Institut Pertanian Bogor (IPB) dalam membangun pemahaman mahasiswa IPB terhadap penerapan PTNBH. Metode yang digunakan adalah kualitatif dengan pendekatan studi kasus. Wawancara mendalam dilakukan kepada Kabid Humas IPB dan Ketua Bem IPB, observasi dan studi pustaka .Teori yang digunakan adalah Kontruksi Atas Realitas, teori Stakeholder, teori  Relationship Management dan konsep Komunikasi Publik. Hasil penelitian menunjukan bahwa pihak IPB mengkonstruksi esensi dari PTNBH yaitu otonomi, keleluasaan dalam penyelenggaraan rumah tangganya untuk menghasilkan pendidikan yang bermutu, ke dalam program-program yang dapat mendukung kemajuan mahasiswa. IPB dapat membangun hubungan menejerial yang alamiah dengan mahasiswa. Penelitian ini menunjukan bahwa strategi komunikasi publik yang dilakukan lembaga dapat membentuk kesepahaman dalam upaya menjaga relasi yang saling menguntungkan antara pengelola atau menejemen IPB/PTNBH dengan mahasiswa.  Kata kunci:  PTNBH, Strategi, Komunikasi publik, Otonomi  The purpose of the research is to analyse the strategy of public communication implemented by Institut Pertanian Bogor (IPB) in developing comprehension of its students towards PTNBH implementation. Method used is qualitative with case study approach. Deep interview is done with Public Relations Head of IPB and Head of BEM (Badan Eksekutif Mahasiswa or Students Executive Board). In addition, this research involves observation and literature study. Theories used in this research are social construct of reality, stakeholder theory, relationship management, and public communication. Result shows that IPB has constructed the PTNBH’s essence of autonomy, freedom in managing its own administration of high quality education, programs in supporting students’ activities. IPB has the capabilities of developing a natural managerial connection with its students. The result also shows that public communication strategy implemented by institution would be able to create understanding and beneficial relationship between administrator/management of IPB and its students.  Keywords: PTNBH, Strategy, Public communication, Autonomy.
Proses Komunikasi Dalam Sosialisasi Pilgub Sumatera Barat Tahun 2015
Authors: Mivadila Melisa , Chatra Emeraldy , Ariany Ria
Published: December 2018

Penelitian ini dilator belakangi oleh pelaksanaan komunikasi KPU Sumatera Barat dalam sosialisasi Pilgub Sumatera Barat Tahun 2015 yang tidak mencapai target partisipasi pemilih sebesar 77,5 %. Penelitian ini dilakukan untuk mendeskripsikan dan menganalisis proses penyusunan, penyampaian serta penerimaan pesan sosialisasi, menemukan hambatan dan mengusulkan model proses komunikasi dalam sosialisasi. Penelitian ini menggunakan metode kualitatif dan dianalisis menggunakan model Boove dan Thil serta glamour theory. Hasil penelitian menunjukkan bahwa pelaksanaan komunikasi dalam sosialisasi belum maksimal dan pesan tidak tersebar merata diterima khalayak. Proses komunikasi dalam Pilgub Sumbar 2015 terdiri dari 8  (delapan) tahap. Hambatan yang ditemukan selama proses komunikasi yakni hambatan dalam proses, semantik, fisik dan psikologis. Hambatan lain yang ditemukan yaitu keterlambatan regulasi dan perencanaan yang tidak maksimal. Model proses komunikasi yang ditambahkan dalam tahapan komunikasi KPU Sumbar adalah tahap evaluasi. Saran dalam penelitian ini yaitu KPU Provinsi Sumbar perlu membuat perencanaan dengan baik, menggandeng relawan demokrasi yang dibekali dengan informasi pemilihan yang lengkap serta evaluasi sebaiknya dilakukan dalam setiap proses komunikasi. Kata Kunci: Proses Komunikasi, Sosialisasi. Tatap Muka.  This research motivate by the implementation of KPU West Sumatra communication in the 2015 West Sumatra Pilgub socialization which did not reach the voter participation target of 77,5%. The research objective are to describe and analyze arrangement process, delivery and acceptance the socialization message, found obstacles and model of communication process in socialization. This research used a qualitative metho, analyze by Boove and Thil Model with the glamour theory. The research found that communication activities in socialization not maximal yet because the message not distribute broadly and accepted by public. The communication process on  the 2015 West Sumatera Governor and Vice Governor Election consist of 8 (eight) phase. There are some obstacles found within communication process; obstacles in the process, semantic, physical and psychological. The others are delays in regulation and improper planning. Evaluation phase is model of communication process which is added on communication phase of West Sumatera Election Commission. The research propose that West Sumatera Election Commission have to plan qualified arrangement, cooperate with democratic volunteers which are provided with proper electoral information, then the evaluation should be performed in every process of communication. Keywords: Communication Process, Socialization, Face to face
Curriculum Setting and Pre-Clinical Dental Students' Stress Level
Authors: Katwala Priya C , Kulkarni Swati Krishna , Guy Nicholas M , Zangaladze Salome , Zak Aleksandra , Stickney Isaac Z , Dubois Stacey , Kang Yang
Published: December 2018

Objectives: The first two years of Dental School are commonly known to be the most stressful in a student’s academic career. Very few studies, however, consider both the pressures of dental school and their causes. In order to understand the relationship between the curriculum and its stressful effects it has on the first (D1) and second-year (D2) dental students, a cross-sectional study was performed at the University of New England College of Dental Medicine (UNE-CDM) during the fall and spring semesters of the 2015-2016 academic year. Methods: 64 D1 and 63 D2 dental students were asked to voluntarily complete an anonymous 27-question survey regarding demographic characteristics and the curriculum-related stressors. Researchers utilized the modified Dental Environment Scale (DES) to rate the stress levels. Results: This study revealed that the D2 students felt more stress than the D1 students overall. D2 students experienced more anxiety in their Spring semester of their second year. In general, students who lived with their immediate family felt less stress. Students twenty-five and over experienced less stress than their younger classmates. Conclusions: The study provided valuable information about the current structure of the curriculum at a newly established dental school. This study could provide insight into curriculum-related stress among pre-clinical dental students, which could guide dental schools in making curricular changes that help alleviate stressors during particularly stressful semesters. Furthermore, the outcomes of this project could provide dental schools the information necessary to develop student support programs to help balance students’ lives and intense course loads.
Exploration of University Faculty Perceptions and Experiences of Service-Learning as Engaged Scholarship of Teaching and Learning
Authors: Arellano Irene , Jones Stephanie J.
Published: December 2018

The purpose of this qualitative instrumental case study was to explore how faculty at a private research university utilize the service-learning pedagogy to advance their scholarship of teaching and learning. Of specific interest was what influences them to utilize the service-learning pedagogy in their scholarship of teaching and learning, and how they perceive that utilizing the service-learning pedagogy affects student learning. Boyer’s work on the scholarship of teaching and learning framed the study. The findings of this study are that the experiential components of the service-learning pedagogy are effective in connecting students to real-world problems. As part of the curriculum it engages students in deeper learning and its use changes students’ perspectives about the importance of community involvement, establishing a community consciousness to those students involved.  The study supports that the service-learning pedagogy is important to higher education faculty and has led to supporting their scholarship of teaching and learning.
Ernährungssysteme nachhaltig umbauen: Vier Handlungsfelder für die Politik
Authors: Eberle Ulrike , Teufel Jenny , Quack Dietlinde , Antoni-Komar Irene , Langen Nina , Hirschnitz-Garbers Martin
Published: December 2018

Politik und Forschung arbeiten bei der Transformation unserer Ernährungssysteme eng zusammen: Im Rahmen der Fördermaßnahme Nachhaltiges Wirtschaften haben Wissenschaftler(innen) Handlungsfelder identifiziert, um nachhaltige Ernährung umzusetzen. Die Ergebnisse
stießen bei der Politik auf Resonanz.
Dr. Seltsam, oder wie ich lernte, die Drohne zu lieben
Authors: Weber Karsten , Rinke Bernhard , Alwardt Christian
Published: December 2018

Drohnen werden inzwischen in vielen und sehr unterschiedlichen Kontexten verwendet. Aus dem Blickwinkel der Technikfolgenabschätzung scheint es daher sinnvoll, den Umfang der momentanen und zukünftigen Nutzung von Drohnen und daraus resultierende Implikationen näher zu beleuchten und eine Bestandsaufnahme durchzuführen. Darüber hinaus sollen die voraussichtlichen Pfade der weiteren Technikentwicklung, relevante Akteure und deren Interessenslage sowie zukünftige Anwendungspotenziale und Einsatzfelder analysiert werden.
Potenzial von Drohnen in der Archäologie
Authors: Crueger Jens
Published: December 2018

Drohnen können in Kombination mit diversen Nutzlasten, etwa Digitalkameras, wertvolle Beiträge zur Dokumentation archäologischer Grabungen und zur Erkundung von Terrain für die archäologische Forschung leisten. Aufgrund der Effizienz und Geschwindigkeit ihrer Datengewinnung, der Möglichkeit schwierige Gelände zu erschließen und ihrer kostengünstigen Anschaffung haben Drohnen das Potenzial, die Archäologie in Richtung eines minimalinvasiven Top-Down-Ansatzes disruptiv zu verändern. Gleichzeitig besteht neben verschiedenen unklaren Rahmenfaktoren das Risiko, dass Drohnen zu einer Bedrohung für das archäologische Kulturerbe werden können.
Drawing Video Game Mental Maps: From Emotional Games to Emotions of Play
Authors: Ter Minassian Hovig
Published: December 2018

By exploring emotions at play in video game experiences, we sought to analyze how people interact with digital spaces in everyday life. Taking a somewhat different view than much of the literature in the field of video game studies, we examined emotions that were created from users’ experience of games, rather than focusing on game design and gameplay. To that end, we based our analysis on 38 video game mental maps drawn by 26 people. We successively analyzed the topic, the structure, and the experiential and emotional meaning of each of the mental maps. Thus, we explored the diversity of emotions that participants linked to video games, and examined the mental maps in relation to what the respondents said about how and why they chose to draw a particular video game. Our work shows the importance of looking beyond the analysis of affects and gameplay, and of examining the emotions produced by the video game experience, along with what they can tell us about the role of games in individual and collective spatial experiences and sociability. Everything doesn’t happen on the screen, and what is lived within the game also depends on what is lived in the physical space of the player. In other words, video games aren’t emotional in themselves, but there are significant video game experiences that contribute to the structuration of individuals.
Investigation on the Tensile Strength of the Friction Stir Welded similar joint of Al/Al alloy using high thermal diffusivity backing plate material.
Authors: Mishra Akshansh , Sharma Abhishek Kumar , Kapoor Hardik , Singh Jaspreet , Kumar Krishna
Published: December 2018

Friction Stir Welding process is a novel green solid state joining process for soft materials such as aluminium alloys. The weld quality is governed by the proper selection of parameters such as forge force rotational speed of the tool,
welding speed, backing plate material etc. Thermal boundary condition at the bottom of the work piece plays an important role for obtaining the sound joint. The backing plate material governs these thermal conditions. In this case study, high thermal
diffusivity backing plate material which consisted of AA2099 was used for joining of the plates of Structural Aluminium alloy. It was observed that the tensile strength was improved.
Preanalytical considerations in therapeutic drug monitoring of immunosuppressants with dried blood spots
Authors: Klak Adrian , Pauwels Steven , Vermeersch Pieter
Published: December 2018

Background

Dried blood spots (DBSs) could allow patients to prepare their own samples at home and send them to the laboratory for therapeutic drug monitoring (TDM) of immunosuppressants. The purpose of this review is to provide an overview of the current knowledge about the impact of DBS-related preanalytical factors on TDM of tacrolimus, sirolimus and everolimus.

Content

Blood spot volume, blood spot inhomogeneity, stability of analytes in DBS and hematocrit (Hct) effects are considered important DBS-related preanalytical factors. In addition, the influence of drying time has recently been identified as a noteworthy preanalytical factor. Tacrolimus is not significantly influenced by these factors. Sirolimus and everolimus are more prone to heat degradation and exhibited variations in recovery which were dependent on Hct and drying time.

Summary and outlook

DBS-related preanalytical factors can have a significant impact on TDM for immunosuppressants. Tacrolimus is not significantly influenced by the studied preanalytical factors and is a viable candidate for DBS sampling. For sirolimus and everolimus more validation of preanalytical factors is needed. In particular, drying conditions need to be examined further, as current protocols may mask Hct-dependent effects on recovery. Further validation is also necessary for home-based self-sampling of immunosuppressants as the sampling quality is variable.
The Application and Effectiveness of Yoga in Prevention and Rehabilitation of Sport Injuries in Athletes Participating in Competitive Sport
Authors: Ravi Sunitha
Published: December 2018

The purpose of the study is to review literature for scientific studies about application and effectiveness of yoga in rehabilitation & prevention of sports injuries in athletes participating in competitive sports. The author conducted a comprehensive search of open access articles of major scientific databases including PuBMed, SCIENCEDIRECT, EBSCO, SCOPUS, Web of Science, etc.. No significant scientific studies were found relating to the application of yoga in rehabilitation and prevention of sport injury. Four studies were selected based on inclusion criteria. One pilot study has included yoga as part of sport conditioning and has investigated use of yoga for flexibility and incidence of non-contact injuries in baseball athletes. The other studies include a clinical example that has used yoga as part of the seven point program in injury treatment of elite football players, an intervention that has included yoga in high-volume training program and a randomised control trial that has evaluated effect of yoga in flexibility and balance among athletes. Conclusions: There is scope for further studies to examine the effect of yoga as an adjunct intervention in rehabilitation of select sports injuries for athletes in competitive sport. There is potential to include sport-specific yoga programs in athletic training for prevention of non-contact injuries.