bluuebunny/crossref_metadata_2025 huggingface dataset:
Anorektale und perineale Schmerzen
Authors: Kugener André , Baumann Philippe
Published: October 2021

Zusammenfassung. Anorektalen Schmerzen liegen meistens organische Erkrankungen im Sinne einer Analfissur, Perianalvenenthrombose, Proktitis, Hämorrhoidalleiden oder gar einer Neoplasie zu Grunde. Die digital rektale Untersuchung wird leider oft vernachlässigt, obwohl anhand dieser die Problematik häufig eingegrenzt werden kann. Allzuoft wird jedoch kein klinisches Korrelat für die Schmerzen gefunden. Spätestens dann kommen, nach Ausschluss einer relevanten Pathologie in der apparativen Diagnostik, die Differentialdiagnosen der funktionellen anorektalen Schmerzen und Pathologien des Beckenbodens mit Ausstrahlung ins Perineum ins Spiel. Namentlich handelt es sich um die Proctalgia fugax, das Levator-ani-Syndrom, die Coccygodynie, die chronische Prostatitis und die interstitielle Zystitis. Die Proctalgia fugax dauert max. 30 min an und die Diagnose stellt sich anhand der Anamnese. Die Therapie ist supportiv (Massage, Sitzbäder, Analdilatation, Vasodilatatoren). Das Levator-ani-Syndroms ist durch eine Schmerzdauer über 30 Minuten und einer schmerzhaften Abtastung der Puborektalschlinge charakterisiert. Durch eine Biofeedbacktherapie, Sitzbäder, Massage oder Neurostimulation kann eine Symptomlinderung erreicht werden. Die neuropathischen und urogenitalen Schmerzbilder mit perinealer Schmerzausstrahlung werden konservativ mit Analgetika, schmerzmodulierenden Antidepressiva oder Antikonvulsiva behandelt. Alternativ kann eine Infiltrationstherapie der Triggerpunkte vorgenommen werden. Die Coccygodynie zählt nicht zu den funktionellen Erkrankungen. Durch gezielte Manipulationen des Steissbeines kann teils eine rasche Beschwerdebesserung erreicht werden.
CME/Antworten: Hypokalzämie und Hypoparathyreoidismus
Authors: Burget Lukas
Published: October 2021

Zusammenfassung. Dyselektrolytämien sind häufig, jedoch nicht auf Anhieb klar zuordenbar. Neben den Hyponatriämien spielen im klinischen Alltag vor allem Hyperkalzämien eine wichtige Rolle. Klinisch nicht weniger relevant sind Hypokalzämien und ein häufig zugrundeliegender primärer Hypoparathyreoidismus, welcher in den meisten Fällen iatrogen – im Rahmen einer Schilddrüsenoperation – bedingt ist. Das therapeutische Ziel umfasst neben einer adäquaten Kalziumeinstellung auch das Miterfassen und -therapieren der Sekundärkomplikationen, falls ein chronischer Hypoparathyreoidismus vorliegt.
AGU Editors Call for Action to Address Global Climate Crisis
Authors: Wooden Paige , Giampoala Matt , Moerchen Margaret
Published: October 2021

As global leaders meet to discuss climate change, AGU’s editors in chief make an appeal for urgent action based on years of accumulated climate science research.
(U‐Th)/He and 4He/3He Thermochronology of Secondary Oxides in Faults and Fractures: A Regional Perspective From Southeastern Arizona
Authors: Scoggin Shane H. , Reiners Peter W. , Shuster David L. , Davis George H. , Ward Lauren A. , Worthington James R. , Nickerson Phillip A. , Evenson Nathan S.
Published: October 2021

Fe‐ and Mn‐oxides are common secondary minerals in faults, fractures, and veins and potentially record information about the timing of fluid movement through their host rocks. These phases are difficult to date by most radioisotopic techniques, but relatively high concentrations of U and Th make the (U‐Th)/He system a promising approach. We present new petrographic, geochronologic and thermochronologic analyses of secondary oxides and associated minerals from fault zones and fractures in southeastern Arizona. We use these phases in attempt to constrain the timing of fluid flow and their relationship to magmatic, tectonic, or other regional processes. In the shallowly exhumed Galiuro Mountains, Fe‐oxide (U‐Th)/He dates correspond to host‐rock crystallization and magmatic intrusions from ca. 1.6 to 1.1 Ga. Step‐heating 4He/3He experiments and polydomain diffusion modeling of 3He release spectra on these samples are consistent with a crystallite size control on He diffusivity, and little fractional loss of radiogenic He since formation in coarse‐grained hematite, but large losses from fine‐grained Mn‐oxide. In contrast to Proterozoic dates, Fe‐ and Mn‐oxides from the Catalina‐Rincon and Pinaleño metamorphic core complexes are exclusively Cenozoic, with dates clustering at ca. 24, 15, and 9 Ma, which represent distinct cooling or fluid‐flow episodes during punctuated periods of normal faulting. Finally, a subset of Fe‐oxides yield dates of ca. 5 Ma to 6 ka and display either pseudomorphic cubic forms consistent with oxidative retrogression of original pyrite or magnetite, or fine‐grained botryoidal morphologies that we interpret to represent approximate ages of recrystallization or pseudomorphic replacement at shallow depths.
A multi-point heart rate monitoring using a soft wearable system based on fiber optic technology
Authors: Lo Presti Daniela , Santucci Francesca , Massaroni Carlo , Formica Domenico , Setola Roberto , Schena Emiliano
Published: October 2021

Early diagnosis can be crucial to limit both the mortality and economic burden of cardiovascular diseases. Recent developments have focused on the continuous monitoring of cardiac activity for a prompt diagnosis. Nowadays, wearable devices are gaining broad interest for a continuous monitoring of the heart rate (HR). One of the most promising methods to estimate HR is the seismocardiography (SCG) which allows to record the thoracic vibrations with high non-invasiveness in out-of-laboratory settings. Despite significant progress on SCG, the current state-of-the-art lacks both information on standardized sensor positioning and optimization of wearables design. Here, we introduce a soft wearable system (SWS), whose novel design, based on a soft polymer matrix embedding an array of fiber Bragg gratings, provides a good adhesion to the body and enables the simultaneous recording of SCG signals from multiple measuring sites. The feasibility assessment on healthy volunteers revealed that the SWS is a suitable wearable solution for HR monitoring and its performance in HR estimation is strongly influenced by sensor positioning and improved by a multi-sensor configuration. These promising characteristics open the possibility of using the SWS in monitoring patients with cardiac pathologies in clinical (e.g., during cardiac magnetic resonance procedures) and everyday life settings.
Knowledge, attitudes and practices of animal farm owners/workers on antibiotic use and resistance in Amhara region, north western Ethiopia
Authors: Geta Kindu , Kibret Mulugeta
Published: October 2021

Inappropriate use of antibiotics in animal and human plays a role in the emergence and spread of bacteria resistant to antibiotics which threatens human health significantly. Although extensive use of these antibiotics could contribute to the development of drug resistance, information on the knowledge, attitude and practice of antimicrobial resistance and use among animal farm owners/workers in north western Ethiopia is rare. The objective of the present study was to assess knowledge, attitude and practice of animal farm owner/workers towards antibiotic resistance and use in Amhara regional state north western Ethiopia. A cross sectional study was conducted in selected cities of Amhara regional state from January to February, 2020. Data was collected from 91 participants using structured questionnaire and analyzed using SPSSS version 23. The results showed that 96.7% of respondents gave antibiotics to treat their livestock from different sources. Most of the respondents bought their antibiotics from private pharmacies without prescription and the most frequently mentioned antibiotics used to treat animal diseases was tetracycline (76.9%), followed by ampicillin (72.5%). Although, 90.1% of the animal farm owners heard about antibiotics and antibiotic resistance from different sources, they did not know the factors contributing to the transmission of resistant bacteria to humans and the impact of antibiotic resistance on human and animals’ health. Using the mean score 4.44 ± 0.15 as the cut-off, half of the animal farm owners/workers had good knowledge about antimicrobial resistance and use. 52.5% of animal farm owners/workers had positive attitudes towards wise antibiotic use and resistance with a mean score of 28.4 ± 0.5. However, 52.75% participants had poor practice with the mean score of practice 4.95 ± 0.17. Better knowledge, positive attitudes and better practices on antibiotic use and resistance were associated with farm owners/workers who engaged in higher education. Although poor awareness on antimicrobial resistance was perceived by 76.9% of respondents as very important factors that contribute to increasing antibiotic resistance, increasing the use of complementary treatments was perceived by the majority of respondents as very important strategies that contribute to reduce antibiotic use and resistance. The current study disclosed that there is low level of awareness among animal farm owners about the correct use of antibiotics and resistance. It is necessary to raise awareness, develop and implement interventions to reduce antimicrobial use and antibiotic resistance in the study area.
Eukaryotic initiation factor 2 signaling behind neural invasion linked with lymphatic and vascular invasion in pancreatic cancer
Authors: Wakiya Taiichi , Ishido Keinosuke , Kimura Norihisa , Nagase Hayato , Yoshizawa Tadashi , Morohashi Satoko , Fujita Hiroaki , Kanda Taishu , Tatara Yota , Saruwatari Junji , Kijima Hiroshi , Hakamada Kenichi
Published: October 2021

Perineural invasion (PNI) is a typical poor prognostic factor in pancreatic ductal adenocarcinoma (PDAC). The mechanisms linking PNI to poor prognosis remain unclear. This study aimed to clarify what changes occurred alongside PNI in PDAC. A 128-patient cohort undergoing surgery for early-stage PDAC was evaluated. Subdivided into two groups, according to pathological state, a pancreatic nerve invasion (ne) score of less than three (from none to moderate invasion) was designated as the low-grade ne group. The high-grade (marked invasion) ne group (74 cases, 57.8%) showed a higher incidence of lymphatic metastasis (P = 0.002), a higher incidence of early recurrence (P = 0.004), decreased RFS (P < 0.001), and decreased DSS (P < 0.001). The severity of lymphatic (r = 0.440, P = 0.042) and venous (r = 0.610, P = 0.002) invasions was positively correlated with the ne score. Tumors having abundant stroma often displayed severe ne. Proteomics identified eukaryotic initiation factor 2 (EIF2) signaling as the most significantly enriched pathway in high-grade ne PDAC. Additionally, EIF2 signaling-related ribosome proteins decreased according to severity. Results showed that PNI is linked with lymphatic and vascular invasion in early-stage PDAC. Furthermore, the dysregulation of proteostasis and ribosome biogenesis can yield a difference in PNI severity.
Defect engineering in trivalent ion doped ceria through vanadium assisted charge compensation: insight using photoluminescence, positron annihilation and electron spin resonance spectroscopy
Authors: Das Debarati , Gupta Santosh K. , Mohapatra M. , Sudarshan K.
Published: October 2021

This work highlighted the strategy to demonstrate the appearance↔disappearance of VO in ceria by choice of the dopant and co-dopant and their relevance in need based defect related applications.
Novel ‘main-part’ isostructuralism in metal complexes with 1-methylimidazole: crystal structures, energy calculations and magnetic properties
Authors: Pérez Hiram , Di Santo Alejandro , Piro Oscar E. , Echeverría Gustavo A. , González Marlene , Ben Altabef Aida , Gomila Rosa M. , Frontera Antonio , Gil Diego M.
Published: October 2021

This manuscript reports novel ‘main-part’ isostructuralism in two new metal complexes with 1-methylimidazole: crystal structures, energy calculations and magnetic properties.
Inherently dinuclear iridium(iii) meso architectures accessed by cyclometalation of calix[4]arene-based bis(aryltriazoles)
Authors: Bezzubov Stanislav , Ermolov Kirill , Gorbunov Alexander , Kalle Paulina , Lentin Ivan , Latyshev Gennadij , Kovalev Vladimir , Vatsouro Ivan
Published: October 2021

Calix[4]arene-based bis(aryltriazoles) allow control of the nuclearity and stereochemistry of iridium bis(cyclometalates) enabling the preparation of permanently dinuclear though tunable architectures having a pure meso environment of two cations.
Alveolar Backing in 3-Year-Old Children With and Without Repaired Cleft Palate: Preliminary Findings Related to Cleft Type and History of Otitis Media
Authors: Zajac David J. , Whitt Hannah , Baylis Adriane , Tourian Maura , Garcia Katie
Published: October 2021

Objective:

The purpose of this preliminary study was to determine if cleft type and/or history of otitis media with effusion (OM) contribute to backing of /t/ and/or /s/ in young children with and without repaired cleft palate (CP).

Method:

Participants were 39 children (
M
age
= 36 months, range: 34–41). Ten children had repaired unilateral cleft lip and palate (CLP), nine had repaired CP only, 12 had no clefts but histories of OM, and eight were typically developing (TD) without clefts or OM history. All children were video- and audio-recorded during administration of the Goldman-Fristoe Test of Articulation–Third Edition (GFTA-3). Standard scores of articulation, frequency of alveolar backing, and first spectral moments of the /t/−/k/ and /s/−/ʃ/ phonetic contrasts were obtained.

Results:

Children with CLP had lower GFTA-3 scores than both TD (
p
= .012) and OM (
p
= .001) groups. Fisher's exact test showed that significantly more children with CLP backed alveolar targets, mostly /s/, than children with CP (
p
= .020). Children with CLP also had (a) reduced /t/−/k/ spectral difference compared to TD children (
p
= .016) and (b) reduced /s/−/ʃ/ spectral difference compared to both children with CP (
p
= .010) and children with OM (
p
= .018). Children with OM had reduced /t/−/k/ spectral difference compared to TD children (
p
= .009).

Conclusions:

Cleft type contributes to alveolar backing and reduced spectral contrast of /s/−/ʃ/ in 3-year-old children with repaired CP. History of OM affects spectral contrast of /t/−/k/ in noncleft children. Etiology and clinical implications of alveolar backing are discussed.
Alternative rapeseed based oil fluid for hydraulic systems of tractors
Authors: Bychenin Alexander P. , Volodko Oleg S. , Bazhutov Denis N.
Published: October 2021

The paper analyzes the main applications of alternative fuels and lubricants in automotive vehicles, considers the possibility of using vegetable oils as a working fluid for hydraulic systems of agricultural machinery. Based on the laboratory findings, it states the ways to improve a lubrication formula based on rapeseed oil. The formula is proven to be optimal if it includes 88.9% rapeseed oil + 3.7% D-11 + 3.2% EFO + 4.197% graphite + 0.003% MS-200A, which is superior in tribological properties to MGE-46V hydraulic oil, and can be recommended for use in hydraulic systems of agricultural machinery as an alternative to mineral oils.
Determination of the parameters of an ellipsoidal electrode tip for treating agricultural animals using UHF – therapy methods
Authors: Fatyanov S.O. , Pustovalov A.P. , Pashchenko V.M. , Morozov A.S. , Semina E.S.
Published: October 2021

The use of non-medicamentous means of treating farm animals presupposes the presence of not only an ultra-high frequency electromagnetic radiation generator but also a rectal emitter, which is directly inserted into the animal's rectum. The effectiveness of the treatment carried out using UHF therapy methods largely depends on the shape of the emitter tip. When choosing the external shape of the emitter tip in the form of half of an ellipsoid of revolution, it becomes necessary to optimize the parameters of this ellipsoid. The goal of optimization is to minimize the resistance force of the living tissue of the animal when a cylindrical emitter with a tip is inserted into the rectum.
The importance of play behavior for dog puppies
Authors: Yudina Olga , Schavel Anna , Sipacheva Anna , Kalinina Irina
Published: October 2021

The study of the influence of game behavior on the mental state of service dogs’ puppies of the German and Belgian (Malinois) shepherd breeds was conducted. The experimental and control groups included puppies of different ages - from 1-2 months to 3-6 months. The puppies of the experimental groups were trained with the use of educational games for puppies and young dogs, the puppies of the control groups did not have such training. As a result of a 6-month study, it was proved that the puppies of the younger experimental group showed the best results in 2 of the 4 tests. And the puppies of the older experimental group showed the best results in all 4 tests, in comparison with the results of the initial testing and the results of the control group.
Changes in the technological properties of sugar beet root crops during industrial storage in ventilated piles
Authors: Egorova Marina , Puzanova Lyubov , Smirnova Lyudmila , Leonteva Elena
Published: October 2021

When storing sugar beets in natural conditions, transformations of the chemical composition occur in it, leading to the accumulation of non-sugars, which reduces the processing efficiency and sugar yield. The use of the technology of forced ventilation of the air environment of the kagats is aimed at reducing the negative impact of the ongoing processes. This study presents the results of changes in the technological properties of sugar beets during industrial storage of two types: in a ventilated rack, in a rack without ventilation. It was shown that forced ventilation of the air in the stagger led to slower development of diseases of root crops with stag rot, the processes proceeded 2 times slower. Changes in the chemical composition of sugar beets after 45 and 60 days of storage are shown. When sugar beets were stored in a ventilated stagger for 60 days, the daily decrease in sugar content was 1.6 times lower than when stored in a staggered rack without ventilation; the increase in the content of reducing substances is 3.5 times lower, α-amino nitrogen, potassium, sodium - on average 1.2 times lower. The calculated sugar yield for the storage conditions of sugar beets in a ventilated trough was 1.1 times higher than when stored in a trough without ventilation. It has been established that the creation of more favorable conditions for the air environment of the sugar beet pile through forced ventilation reduces the intensity of natural biochemical and microbiological processes in root crops, extends the shelf life of their technological properties, and ensures the economic efficiency of sugar production.
Hemodynamic index of animals with burning injury treated with “Acerbin”
Authors: Pereverzev Alexander , Everstova Elena , Tolkachev Vladimir
Published: October 2021

Thermal injuries are wide spread among home pets and are represented as a recent problem of veterinary medicine because of the lack of anti-burn drugs adapted for use in veterinary medicine. In this regard, the aim of our work is to certify the vulnerary spray “Acerbin” for medical purposes in the treatment of thermal injuries of animals and to evaluate its therapeutic potency according to the dynamics of healing burn injuries and recovery of the blood cell composition. The research was carried out on 60 laboratory white mice. Thermal injuries of the skin integument on the dorsal surface of the croup were simulated; the “Acerbin” spray was further applied. To achieve the aim, the blood samples and planimetric measured tests of the area of burn defects were taken on the 3rd, 5th, 7th, 10th and 14th day of treatment. The samples were analyzed by the quantitative content of erythrocytes, thrombocytes, leucocytes and cHb (blood hemoglobin concentration) using an automatic hematological analyzer “Abacus vet 10”. Planimetric indicators of the area of burns were subjected to mathematical processing with the calculation of the rate of epithelization of the burn injury. The obtained hematological and planimetric digital indicators were processed by statistical methods of analysis, compared and then interpreted.
Graduation technique for vibration flow device for grain mass moisture control
Authors: Ivashina Alexander , Adoshev Andrey , Antonov Sergey , Zhdanov Valery
Published: October 2021

The article shows that sampling of grain while controlling the moisture content is carried out in accordance with the current recommendations and standards. The mass of a sample should be sufficient to form 10-15 samples with uniformly distributed moisture values with an interval of no more than 3-4% in the measurement range of a vibration-flow moisture meter. Determination of grain moisture is carried out by the thermogravimetric method using a drying oven as a standard in the following sequence. Measurements with a moisture meter are taken at least three times. For the final measurement result, the average value α of the moisture meter readings from a series of successive measurements is taken. The range in a series of measurements should not exceed 0.05α; otherwise the measurements are repeated. The moisture measurement results and the corresponding readings of the device are entered in the appropriate table. When constructing graduation curves, a correlation-regression analysis of the measurement results is carried out, which is as follows. A correlation field is constructed - a graphical representation of the relationship between the moisture values of the material Wi and the readings of the moisture meter αi. If the analysis is performed correctly, the theoretical regression line plotted on the correlation field should be located as close as possible to the experimental measurement points. The basic error of the vibration-flow moisture meter, obtained as a result of the calculation, should not exceed the permissible value. Otherwise, the graduation of the moisture meter is repeated.
Application of the principal component analysis (PCM) as an innovative technology for assessing the morphological and functional state of agricultural poultry with diseases of bacterial genesis
Authors: Lovtsova Larisa , Pidenko Sergei , Isaicheva Lyudmila , Smutnev Petr , Shkel Andrey
Published: October 2021

The possibility of using the method of principal components (PCM) for analyzing the results of hematological studies of blood samples of broiler chickens has been studied. It was found that the graphs of the residual dispersion show a clear clustering of samples into the control and experimental groups after infection in the PC1-PC2 space. The graphs of the scores, built for the higher BG models, showed changes in the values for the GC1 spectrum of leukocytes, and for the GC2 of erythrocytes, hemoglobin. Thus, the use of PCM analysis of hematological blood data makes it possible to separate blood samples from healthy broiler chickens and those susceptible to infection with various infections. PCM is a promising approach for rapid assessment of hematological data.
Biological features and economically valuable characteristics of apple varieties (Malus domestica Borkh.)
Authors: Merezhko Olga , Aminova Evgenia , Salimova Rufina
Published: October 2021

The purpose of the research is to create winter-hardy, large-fruited, high-yielding, high-quality varieties of apple trees of different ripening periods and their growing technology (use of a biological product) in the South Urals. The research was carried out on the basis of Orenburg a branch of the Federal State Budgetary Scientific Institution "Federal Scientific Selection and Technology Center for Horticulture and Nursery" from 1999 to 2020. Research objects were summer apple varieties – Orenburgskoe, Orenburgskoe krasnoe, Letnee polosatoe (K); winter – Orenburgskoe pozdnee, Zimnee, YUzhnoural'skoe (K). The counts and observations were carried out according to generally accepted methods. As a result of the studies, the data obtained showed that the property of short stature as a genetic trait of resistance is transmitted to the offspring during hybridization. The varieties Orenburgskoe pozdnee, Zimnee and YUzhnoural’skoe showed the greatest increase in productivity embodiment experience “Evrikor − Forte + 7” 2.5 l / ha by 25.4%, 24.3% and 22.2% respectively. Thus, the application of "Evrikor − Forte + 7" increased both the number of fruits and their weight, and also increased the yield of the studied varieties.
Effect of Combined Dressing Agents on Phytosanitary Situation in Winter Wheat Ecosystems
Authors: Vasin Vasily G. , Pertseva Elena V. , Kiseleva Lyudmila V. , Kozhevnikova Oksana P.
Published: October 2021

The Middle Volga forest-steppe was subject to a comparative assessment to evaluate the effectiveness of combined insect-fungicidal pesticides as regulators of a phytosanitary state of farming ecosystems and yields of winter wheat. Insect-fungicidal pesticides used for pre-sowing treatment do not guarantee unconditional success, but they help to significantly reduce pest-induced losses and obtain safer grain produce. Regulated seeding rates showed that, once applied, combined dressing agents become slightly less biologically effective with overcrowding or thinning of crops. Dividend Supreme effectively reduced damage to shoots by Swedish flies, slightly worse than Celest Top. Celest Top and Dividend Supreme ensured stable suppression of root rot during the years of research. The winter wheat increasingly lodged when Celest Top and Dividend Supreme were used for seed dressing compared to the control (without dressing). Insect-fungicidal dressing agents increased the yield of winter wheat compared to the control and, at the same time, the risk of lodging. This effect was especially noticeable when Celest Top was used. It is recommended to use the combined Dividend Supreme and Celest Top pesticides for ensuring a stable phytosanitary situation and obtaining a high-quality harvest with a seeding rate of the target crop of 2-3 million seeds per 1 ha.
Prospects of the use of prebiotics in broiler poultry farming as an alternative to antibiotics
Authors: Reznichenko Aleksei , Reznichenko Liudmila , Dorozhkin Vasilij , Noskov Sergej , Vodianitskaia Svetlana
Published: October 2021

The uncontrolled use of antibacterial drugs resulted in a wide spread of forms of microorganisms resistant to them. The resistance of most bacteria to one degree or another is observed in relation to almost all existing antibiotics, which led to a significant decrease in the effectiveness of their use not only in veterinary medicine but also in medicine. Therefore, an important task which veterinary service faces is the use of alternative antibacterial drugs. Thus, the development and use of prebiotics in the food of poultry for complete or partial replacement of antibiotics is considered as a new direction of modern scientific research. The authors were the first who studied the effect of the heteropolysaccharides “raspol” and “vetelac” on the organism of broiler chickens. A high pharmacological effect of both drugs was established with a clear advantage of raspol, the use of which, against the background of the absence of antibiotics, had a positive effect on the growth and viability of poultry and caused an increase in the natural resistance of organisms. Thus, prebiotic raspol can be used as an alternative to antibacterial agents in broiler poultry farming. This drug is recommended for the give to broiler chickens with water at the rate of 0.6 g / kg of body weight starting from 7 days of age for 10 days.
Clinical studies of the Tildox AVZ complex drug efficacy in respiratory and gastrointestinal pathologies of young pigs caused by opportunistic microflora
Authors: Engashev Sergey V. , Savinkov Aleksey V. , Sadov Konstantin M. , Iliasov Pavel V.
Published: October 2021

This publication provides a study of the efficacy of Tildox AVZ (a combined formulation of doxycycline and tylosin) in non-specific bacterial respiratory and gastrointestinal pathologies in piglets. The study population included 70 piglets with respiratory and gastrointestinal pathologies randomized into 6 groups. The effects of investigational drug used according 3-day or 5-day regimen were assessed using clinical examination, as well as bacteriological, blood count and blood chemistry lab tests. The investigational drug (Tildox AVZ) was safe for target animals and had no adverse effects, showed a similar species specificity and efficacy on the respiratory and gastrointestinal flora in piglets vs. the reference drug (Gentamicin) and allows achieving a beneficial clinical effect in respiratory and gastrointestinal diseases caused by opportunistic microflora. A significant clinical effect is achieved by Day 4 in gastrointestinal pathology and by Days 6-7 in respiratory pathology. Moreover, the control group with gastrointestinal pathology had no changes in the most of the parameters vs. baseline even on Day 7. Tildox AVZ had no adverse effects on blood count and blood chemistry parameters; on the contrary, for a number of parameters, a trend towards normalization was noted. The investigational drug was at least equivalent to the reference one (Gentamicin) and can be used for both respiratory and gastrointestinal disorders caused by the non-specific opportunistic bacterial microflora.
Milk productivity of black-and-white and Kholmogory cows with different genotypes of kappa-casein
Authors: Shaidullin Radik , Zagidullin Lenar , Moskvicheva Anastasia , Khisamov Rifat , Akhmetov Tahir
Published: October 2021

The influence of genotypes for kappa-casein gene on the main indicators of milk productivity in the 1st and 3rd lactation in black-and-white and Kholmogory cows was studied. The genotyping of cows for the CSN3 gene was carried out by the method of DNA diagnostics. Cows of the black-and-white breed with genotype CSN3 BB surpass the group with genotype CSN3 AA and CSN3 AB in the 1st lactation in milk yield by 166-218 and in milk fat yield by 4.9-8.7 kg; for the 3rd lactation 188-298 kg and 7.7-10.2 kg, respectively. At the same time the difference is significant in terms of the mass fraction of protein in milk by 0.06-0.15% (Р<0.05-0.001) and 0.11-0.15% (Р<0.001) and in the yield of milk protein (Р<0.05) 8.3-14.2 kg and 14.8-16.1 kg (P<0.05). Kholmogory cows have a similar advantage for cattle with genotypes CSN3 AA and CSN3 AB in terms of milk productivity with a significant excess in the mass fraction of protein in milk for the 1st lactation by 0.07-0.14% (Р<0.05-0.001), for the 3rd lactation by 0.08-0.11% (Р<0.05-0.001). Consequently, the black-and-white and Kholmogory breeds have approximately the same level of superiority of cows homozygous for B allele CSN3 over their herdmates.
The Effect of the Drug Estrofan on the Content of Nitric Oxide (II), Sex Hormones, Biochemical Parameters and Their Relationship in Cows
Authors: Sibgatullin I.T. , Gilmutdinov R.Ya. , Zakirov T.M.
Published: October 2021

The physiological functions of nitric oxide (II) are diverse, and its therapeutic uses continue to expand. Many methods have been found to regulate the production of this compound, both physiological, regulated by the body itself, and as a result of various, drug and non-drug, external influences, correcting the ability of cells, organs and tissues to produce nitric oxide (II). The drug estrophan (synthetic prostaglandin PGF2α) has an activating effect on the nitric oxide (II) system and on sex hormones that regulate the reproductive functions of cows. The introduction of estrophan to cows is accompanied by an increase in the synthesis of nitric oxide (II), estrogen in the body of cows, and a decrease in progesterone. A high level of interrelation of estrogen with nitric oxide (II) was shown, the value of the correlation coefficient is (r = 0.552; p < 0.05). Correlation of the level of nitric oxide (II) with estrogen allows making an assumption of its bioregulatory functions, including the sexual cycle. The introduction of estrophan had no effect on the biochemical parameters in the blood serum of cows.
Natural Restoration of Norway Maple Stands in the Conditions of the Republic of Tatarstan
Authors: Singatullin Irek , Khakimova Zulfiya , Chernov Vasily , Ilyin Fedor
Published: October 2021

The article provides an analysis of changes in the areas of Norway maple stands in the forests of the Republic of Tatarstan from 1944 to 2019. According to the accounting data of the forest fund as of 01.01.2020, the area occupied by maple in the Republic of Tatarstan is 29.3 thousand hectares (2.5 % of the forest fund area), including 5.0 thousand hectares of young growth of the 1st and 2nd age class, 21.4 thousand hectares of middle-aged trees, 1.9 thousand hectares of ripening trees and 1.0 thousand hectares of ripe trees. A reliable relationship was revealed between a decrease in the area of maple after extremely low frosts of 1939–1940, 1941–1942 and 1978–1979, and an increase in its area after the drought of 2010. After the drought of 2010, there is a natural replacement of highly productive birch stands with low-quality maple stands, which will lead to a deterioration of the commodity structure of the felling fund of the Republic of Tatarstan. Maple plantations have a mixed composition and farming in them should be aimed at increasing the proportion of species valuable for these conditions – oak and birch.
Biological systems for the protection of spring rapeseed from pests as a promising direction for a production increase of environmentally friendly and competitive oilseeds in the Republic of Tatarstan
Authors: Suleimanov Salavat , Safiollin Ravil , Loginov Nikolay , Vafina Lilia
Published: October 2021

This paper presents the ideas of the authors, confirmed by the results of a stationary field experiment on the possibility of widespread use of modern biological products of insecticidal action in the system of protection of the main oilseed crop of the Republic of Tatarstan namely spring rapeseed from such most harmful objects as cruciferous flea, cabbage moth, rape sawfly, flower beetle, secretive proboscis etc. The stationary field experiments were carried out on the basis of the agrarian biological technological park of Kazan State Agrarian University. The laboratory analyzes were carried out at the center of agroecological research of the agronomic faculty. The soils of the experimental site were gray forest, with the following agrochemical indicators: the content of humus according to Tyurin was 3.0%, mobile phosphorus was high (160 mg / kg) and exchangeable potassium was increased (145 mg/kg according to Kirsanov). The objects of research were the crops of spring rape of the Ruyan variety named after V.S. Pustovoyta, biological preparations Nodix Premium, Nodix Insectobact and Nodix Biofungicide. The importance of these studies is explained by the fact that in recent years, the number and resistance of pests of spring rape to chemical insecticides has increased and, accordingly, the chemical load on the environment has also increased. In this regard, the study of promising insecticides of biological origin on spring rape is an urgent task. During the research, it was found that the pre-sowing treatment of seeds with Insectobact (1 l / t of seeds) in combination with a nutrient solution Nodix Premium (0.3 l / t) in terms of the effectiveness of suppressing cruciferous flea bees is equivalent to dressing the seed with a chemical dressing agent Cruiser Rape (15 l / t). t). Moreover, a significant reduction in the chemical load on the environment ensures the use of the same biological products against other pests during the growing season of plants.
Crop Management System Based on Digital Technologies
Authors: Zakirova A.R. , Klychova G.S. , Yusupova A.R. , Nikitenko I.G. , Zakirov A.M.
Published: October 2021

Crop farming is one of the most important branches of agriculture that ensures the food security of the country. For crop farming development, it is necessary to solve the problems of reducing the quantity and quality of the resulting crop due to insufficient nutrition and care, untimely harvesting and improper storage. To increase the efficiency and sustainability of the industry, it is necessary to digitalize both the production systems and decision-making processes at all levels of management. The study considers the stages of a digital crop management system: accounting for acreage with an electronic field map; organization of crop rotation taking into account organizational, soil-climatic and economic aspects of production; monitoring of technological operations; control of agricultural machinery with the formation of primary documents for accounting for completed works; maintaining a subsystem of material resources using the technic of precision farming; filling in technological maps and accounting for actually completed works with a list of works, the composition of agricultural aggregates, the timing of operations, production rates and fuel consumption, the need for seeds, fertilizers, plant protection products, and the cost of resources. The increased attention to the problem of digital agriculture on the part of the state and the highly competitive environment promote the use of new technological mechanisms and methods of work by agricultural producers, which are based on the use of Internet technologies, satellite navigation, robotics, sensors and sensors, and unmanned vehicles. Digitalization of agricultural processes allows increasing crop productivity, the efficiency of using material resources, equipment and human potential.
Erfolgreiche Skaphoidrekonstruktion durch einen erneuten freien medialen Femurkondylenspan
Authors: Landscheidt Kristina , Lauer Henrik , Goertz Ole , Hernekamp Jochen-Frederik
Published: October 2021

Falldarstellung

Ein 39-jähriger Patient stellte sich mit Schmerzen im Bereich des rechten Handgelenkes in unserer Sprechstunde vor. Eineinhalb Jahre zuvor war der Patient mit dem Fahrrad verunfallt und dabei auf die rechte Hand gestürzt. Aufgrund persistierender Schmerzen wurde der Patient ein Jahr nach Unfall erstmals ein einer externen handchirurgischen Abteilung vorstellig, wo eine Skaphoidpseudarthrose diagnostiziert wurde. Es folgten eine Pseudarthrosenresektion und die Interposition eines mikrovaskulär angeschlossenen Femurkondylenspans von der Gegenseite mit K-Drahtosteosynthese, gefolgt von einer 6-wöchigen Ruhigstellung (
Abb. 1
).
Resorcinarene-Based Supramolecular Capsules: Supramolecular Functions and Applications
Authors: Haino Takeharu , Sekiya Ryo , Harada Kentaro , Nitta Natsumi
Published: October 2021

A resorcinarene is a synthetic macrocycle consisting of four resorcinol molecules covalently linked by methylene bridges. The interannular bridges produce a cavitand that has a bowl-shaped structure. We have developed supramolecular capsules through Ag(I) or Cu(I) coordination-driven self-assembly of cavitands possessing 2,2′-bipyridyl arms in their upper rims. The self-assembled capsules accommodate various molecular guests and supramolecular assemblies possessing acetoxy groups. The host–guest chemistry of the molecular capsules has been applied in the fabrication of supramolecular polymers. This account describes recent developments in the supramolecular chemistry of resorcinarene-based coordination capsules and provides a brief history of resorcinarene-based capsules and related capsules.
DRK-Kliniken Nordhessen: Helios übernimmt insolventen Klinikträger für einen Euro
Authors: Heeser Alexandra
Published: October 2021

Deutschlands größter privater Klinikkonzern hat die finanziell stark angeschlagenen DRK-Kliniken Nordhessen für einen symbolischen Preis gekauft. Beide Klinikstandorte und das angeschlossene MVZ bleiben danach weiterhin erhalten, der im Juni gestellte Insolvenzantrag der DRK-Kliniken soll nun zurückgenommen werden.
Health-IT: In Kauflaune
Authors: Doelfs Guntram
Published: October 2021

Erst waren es nur die Bereiche Reha und ambulante Versorgung. Nun jedoch entdecken Private-Equity-Firmen auch Gesundheits-IT-Unternehmen als lohnende Anlage. Ein Gespräch mit Matthias Meierhofer, Chef der Meierhofer AG, über zunehmende Anfragen von Finanzinvestoren, überzogene Renditeerwartungen und den laufenden Umbruch im deutschen Healthcare-IT-Markt.
Desinfektionsroboter: Gebäudedaten weisen den Weg
Authors: Wenzel Günter
Published: October 2021

Fraunhofer-Forscherinnen und -Forscher haben den Roboter Balto entwickelt, der, auch im Verbund mit weiteren Robotern, anhand von aktuellen Gebäudedaten gezielt die Türen in einer Klinik anfahren und Türklinken desinfizieren kann.
Panel gaps are a cost-effective alternative to cool photovoltaic systems
Authors: Patrick Chris
Published: October 2021

A stepped, multilayer arrangement enhances the efficiency of photovoltaic panels compared to a single-layer arrangement.
Networked discourses of bereavement in online COVID-19 memorials
Authors: McGlashan Mark
Published: October 2021

This paper reports on study of online COVID-19 memorials posted during 2020 to the Church of England website https://www.rememberme2020.uk/. The paper employs a Corpus-Assisted Discourse Studies (CADS) approach to analyse networks of co-occurring linguistic items (types and lemmata) and patterns (ngrams) within online memorials, and examines how these frequent items/patterns exist within networked discourses that underpin an overarching bereavement discourse. The analysis finds that bereavement discourse is underpinned by frequent reference to love, relationships and relational identification, time and temporality, loss/absence, and memory, as well as metaphors based on container and journey image schema. An analysis of these metaphorical representations of death and bereavement suggest that online memorials serve as a space for the social practice of bereavement and shows how the language used to grieve attempts to ideologically (re)present the relationships between the bereaved and decedent. All code used in this paper can be found at https://osf.io/khcj2/.
Mechanical rolling and annealing of wire-arc additively manufactured stainless steel plates
Authors: Elmer John W. , Gibbs Gordon
Published: October 2021

Thin walls of 304L stainless steel were fabricated by wire-arc additive manufacturing (WAAM) followed by post-build thermomechanical processing to modify the as-built microstructure and properties. The walls were made using a high-deposition-rate robotically controlled gas metal arc welding system and were characterised using optical microscopy and tensile tested for mechanical properties. Post-processing consisted of mechanical rolling the walls to 25% and 40% strains, followed by annealing at 1050°C to demonstrate a wide range of properties. Results show that WAAM can be used to build custom-sized semi-finished parts or blanks that can later be thermomechanically processed to increase strength and ductility through recrystallisation of the as-built microstructure, and/or processed into desired shapes with improved mechanical properties.
Current observations are insufficient to confidently associate the binary black hole merger GW190521 with AGN J124942.3 + 344929
Authors: Ashton Gregory , Ackley Kendall , Hernandez Ignacio Magaña , Piotrzkowski Brandon
Published: October 2021

Recently, Graham et al (2020 arXiv:2006.14122) identified ZTF19abanrhr as a candidate electromagnetic counterpart to the binary black hole merger GW190521. The authors argue that the observations are consistent with a kicked binary black hole interacting with the accretion disk of the active galactic nucleus AGN J124942.3 + 344929. If a real association (rather than happenstance), this has implications for the sources of LIGO/Virgo binary mergers, future prospects for electromagnetic counterparts, and measurements of the expansion rate of the Universe. In this work, we provide an analysis of the multi-messenger coincident-significance based on the localisation overlap and find that, under optimistic assumptions, the odds of a common source for GW190521 and ZTF19abanrhr range between 1 and 12. These odds are strongly dependent on the waveform model and, with current models, are unable to consistently capture both the effects of precession and orbital eccentricity. We consider this insufficient evidence to warrant confidently associating GW190521 with ZTF19abanrhr and hence caution against any astrophysical conclusions based on the association.
Effect of the cosmological parameters on gravitational waves: general analysis
Authors: Espriu Domènec , Rodoreda Marc
Published: October 2021

Some time ago it was pointed out that the presence of cosmological components could affect the propagation of gravitational waves (GW) beyond the usual cosmological redshift and that such effects might be observable in pulsar timing arrays (PTA). These analyses were done at leading order in the Hubble constant H
0, which is proportional to

Λ

1

2

and

ρ

i

1

2

(ρ

i
being the various cosmological fluid densities). In this work, we study in detail the propagation of metric perturbations on a Schwarzschild–de Sitter (SdS) background, close to the place where GW are produced, and obtain solutions that incorporate corrections linear in ρ

i
and Λ. At the next-to-leading order the corrections do not appear in the form of H
0 thus lifting the degeneracy among the various cosmological components. We also determine the leading corrections proportional to the mass of the final object; they are very small for the distances considered in PTA but may be of relevance in other cases. When transformed into comoving coordinates, the ones used in cosmological measurements, this SdS solution does satisfy the perturbation equations in a Friedmann–Lemaître–Robertson–Walker metric up to and including

Λ

3

2

terms. This analysis is then extended to the other cosmological fluids, allowing us to consider GW sources in the Gpc range. Finally, we investigate the influence of these corrections in PTA observations.
Large exciton binding energy, superior mechanical flexibility, and ultra-low lattice thermal conductivity in BiI3 monolayer
Authors: Xiao Wen-Zhi , Xiao Gang , Wang Zhu-Jun , Wang Ling-Ling
Published: October 2021

The exciton binding energy, mechanical properties, and lattice thermal conductivity of monolayer BiI3 are investigated on the basis of first principle calculation. The excitation energy of monolayer BiI3 is predicted to be 1.02 eV, which is larger than that of bulk BiI3 (0.224 eV). This condition is due to the reduced dielectric screening in systems. The monolayer can withstand biaxial tensile strain up to 30% with ideal tensile strength of 2.60 GPa. Compared with graphene and MoS2, BiI3 possesses superior flexibility and ductility due to its large Poisson’s ratio and smaller Young’s modulus by two orders of magnitude. The predicted lattice thermal conductivity k
L of monolayer BiI3 is 0.247 W m−1 K−1 at room temperature, which is lower than most reported values for other 2D materials. Such ultralow k
L results from the scattering between acoustic and optical phonon modes, heavy atomic mass, and relatively weak chemical bond.