bluuebunny/crossref_metadata_2025 huggingface dataset:
THE EFFECTIVENESS OF PHOTODYNAMIC THERAPY WITH AN EXTERNAL PHOTOSENSITIZER GEL BASED ON CHLORIN E6 IN THE CORRECTION OF POST-ACNE SCARS
Authors: Dubensky Valery , Alexandrova Olga Alexandrova , Nekrasova Elizaveta , Shneyder Viktoriya , Selezneva Anzhelika
Published: September 2024

Purpose of the Study: To evaluate the effectiveness of photodynamic therapy in the treatment of post-acne scars. Materials and Methods: We have presented a clinical case of the correction of post-acne with photodynamic therapy after a preliminary course of systemic retinoids. A 23-year-old patient with a 10-year history of acne lesions was diagnosed with severe acne complicated with atrophic scars and dyschromia. Results: The use of photodynamic therapy with an external gel, a photosensitizer based on chlorin E6, proved to be highly effective in correcting the post-acne complications. The use of a personalized approach when determining the exposure of the gel on the skin established its highest concentration after 10 minutes and the optimal duration of irradiation within 10 minutes. As a result of treatment, there was a restoration of skin color and a decrease in the depth of atrophic scars. Conclusions: This case is of interest to dermatologists/aesthetic physicians, since an effective method of using photodynamic therapy with a topical photosensitizer gel in the correction of post-acne scars was proposed.
UI/UX Design Modeling on Chatting and Forum Applications Using Design Thinking
Authors: Anantya Arya Rezza , Wijaya Anugerah Bagus , Suliswaningsih Suliswaningsih
Published: September 2024

Informatics is one of the study programs at the private university of Amikom University Purwokerto which prioritizes learning on the development of Information Technology, but the problems faced vary such as the absence of a campus facility for discussion and community, difficulty in conveying the problems they face, especially related to assignments and materials presented by lecturers. The purpose of this study is to design a visual concept of user interface design and prototype flow design for the Chatting and Forum Discussion Forum application using the Design Thinking method. The method used involves iterative steps to understand user needs, build prototypes, and test the resulting solutions. In addition, the usability testing method is used to test the prototype results of the interface that has been created, with a focus on user experience. The final result of this study is a user interface and prototyping that have passed the testing stage according to usability testing standards, task completion testing using the SEQ (Single Ease Question) method on each task has an average task completion above 6. And the results of the SUS (System Usability Scale) method have a value of 88.3 meeting the SUS acceptable scoring aspect with a grade scale B which shows that the project created is easy to use. Successfully designed a visual design concept through user interface and user experience design of online discussion forum platform media using the Design Thinking method through the stages of Empathize, Define, Ideate, Prototype, and Testing.
Моделювання розподілених транзакцій за допомогою мереж Петрі
Authors: Iwaniak M. , Khadzhynov W.
Published: September 2024

Зроблено спробу використання простої мережі Петрі для моделювання й дослідження три-фазного протоколу фіксації (3РС). Наведено короткий огляд мереж Петрі. Пояснено сутність зви-чайних і розподілених транзакцій. Дано опис кроків протоколу 3РС. Проаналізовано доступність мережі Петрі з протоколом 3РС і досліджено властивості запропонованої мережі. Табл.: 5. Іл.: 4. Бібліогр.: 4 найм.
Percoca, percocca o percoco? Basta che sia succosa!
Authors: Altissimi Elisa
Published: September 2024

I nostri lettori si chiedono se il termine percoca, che indica una varietà di pesca, sia italiano o dialettale, quale sia la forma corretta tra percoca e percocca; altri chiedono se per indicare lo stesso frutto si possa usare il sostantivo maschile percoco.
Analisis Harga Pokok Produksi Dengan Metode Full Costing Pada UMKM Angkringan RM 46
Authors: Pradnya Prabaningrum Prismada Adhe , Setyawan Chindi , Nabillah Shaafiyah Novi
Published: September 2024

Dalam upaya menghasilkan produk yang berkualitas dengan harga yang kompetitif, UMKM saling berkompetisi secara intensif, perhitungan harga pokok produksi merupakan hal yang penting untuk diperhatikan. Penelitian ini menyelidiki penggunaan metode biaya penuh sebagai alat untuk menghitung harga produk pada Angkringan RM 46. Penelitian ini menemukan bahwa harga pokok produksi memasukkan biaya bahan baku, tenaga kerja langsung, overhead pabrik, perlengkapan kantor, dan transportasi. Dalam penelitian ini, metode secara sederhana masih digunakan untuk menghitung harga pokok produksi Angkringan RM 46. Peneliti belum menerapkan ketentuan dari kaidah akuntansi biaya untuk menghitung harga pokok produksi. Hasil analisis menunjukkan bahwa nilai biaya usaha Angkringan RM 46 dibandingkan dengan nilai biaya peneliti lebih baik  menggunakan metode full costing.
Pengaruh Risiko Pasar dan Risiko Kredit terhadap Profitabilitas Perusahaan
Authors: Mawarti Nufikha Ayu , Keristin Usnia Wati
Published: September 2024

In this study, the aim is to formulate whether a company's profitability is influenced by market risk and credit risk. The objective is to analyze the profitability of companies influenced by market and credit risks. This research study utilizes secondary data from the financial reports of banks from 2018 to 2022. The population for this study consists of 47 banking companies. The data collection technique employed in this study is documentation. A total of 33 companies are selected as samples using purposive sampling. The research conducts hypothesis testing through multiple linear regression analysis. The results indicate that market risk has a positive and significant partial effect, while credit risk has a significant negative impact on profitability. Market risk and credit risk jointly have a significant influence on profitability.
Mengatasi Rintangan Birokrasi: Pengembangan Karir di Lingkungan Pemerintahan Daerah
Authors: Kurnia Nina , Robby Robby
Published: September 2024

Penelitian ini bertujuan untuk mengidentifikasi hambatan-hambatan dalam pengembangan karir di Sekretariat Daerah Kabupaten Pangkep. Metode penelitian menggunakan pendekatan kualitatif dengan teknik observasi dan wawancara mendalam. Temuan menunjukkan bahwa kurangnya integrasi visi antara pegawai dan organisasi, dominasi aturan kepegawaian yang sentralistik, serta komunikasi nonformal yang dipengaruhi oleh kedekatan personal menjadi faktor utama yang menghambat pengembangan karir.
Peran Komunikasi Verbal dan Nonverbal dalam Kualitas Layanan Publik
Authors: Tania Reni , Hamson Zulkarnain
Published: September 2024

Penelitian ini bertujuan untuk menginvestigasi pengaruh komunikasi verbal, nonverbal, dan gaya bahasa dalam konteks layanan publik terhadap persepsi dan respons masyarakat di Indonesia. Metode penelitian yang digunakan adalah pendekatan kualitatif dengan teknik wawancara mendalam terhadap berbagai responden yang mewakili beragam latar belakang dan pengalaman. Temuan penelitian menunjukkan bahwa tingkat klaritas komunikasi verbal dan nonverbal serta pemilihan gaya bahasa yang tepat sangat mempengaruhi pemahaman dan interaksi antara pelayan publik dan masyarakat, dengan efek signifikan terhadap kepuasan dan partisipasi masyarakat dalam layanan publik. Kata kunci: komunikasi verbal, komunikasi nonverbal, gaya bahasa.
EFFECT OF ORAL CLONIDINE PREMEDICATION ON PRESSOR RESPONSE FOR PATIENTS UNDERGOING ABDOMINAL SURGERIES UNDER GENERAL ANAESTHESIA.
Authors: Singh Ajmani Tejinder , Pareek Somya
Published: September 2024

Introduction: Preanesthetic medication forms an integral part of anaesthesia management. The premedicant should be
easy to administer and should have analgesic and anti-emetic properties, should not impair cardiovascular stability or
depress respiration, should have antisialagogue effect and should effectively alleviate apprehension of the patient[1]. Alpha-2 adrenoceptor
agonists have been used as premedicant from 1999 onwards. Clonidine hydrochloride when used as premedicant, it facilitates conduct of
anaesthesia and attenuates hemodynamic responses to laryngoscopy and intubation, reduction in stress response to surgery, dose of inhalational
anaesthetic, narcotic requirements and provides perioperative hemodynamic stability[2][3]. Proposed study was designed to evaluate the effects
of oral clonidine premedication on pressor response in patients undergoing abdominal surgeries. Methodology: On the approval of the
Institutional Ethical Committee 50 adult patients belonging to ASA grade I and II scheduled for elective surgery were divided in two groups of 25
each. Group I: Patients were given Tablet clonidine 150 mcg orally 90 mins before induction of anaesthesia. Group II: Patients were given
Vitamin C tablets 100 mg (placebo) orally 90 mins before induction of anaesthesia. After 90 minutes, the patients were shifted to operating
room and the preoperative hemodynamic parameters – Heart rate, ECG, SBP, DBP, MAP recorded. Results: The study conducted clearly
indicated that the oral clonidine premedication attenuates the sympathoadrenal response during critical phases of anaesthesia like laryngoscopy
and endotracheal intubation, intraoperatively, during extubation and in immediate postoperative period. Conclusion: The study provides clear
evidence in support of premedicating the patients with clonidine under varieties of surgical circumstances. Clonidine whether administered by
oral or by intravenous route provides statistically signicant and clinically meaningful benecial effects. Preoperative medication with
clonidine reduces preoperative anxiety and provides sedation with mild analgesia & hemodynamic stability in stressful times of anaesthesia and
surgery and postoperatively. It does cause minor side effects like bradycardia and hypotension that are easily manageable.
ASSESSMENT OF KNOWLEDGE, ATTITUDE, PRACTICE AMONG PATIENTS WITH HYPOTHYROIDISM IN A TERTIARY CARE HOSPITAL AT PUDUCHERRY - A CROSS SECTIONAL STUDY
Authors: Bharath Kumar Nanyampalli , Ponnambalam A. , K Suresh.
Published: September 2024

Back ground Hypothyroidism is a commonest endocrine disorder globally. The awareness of the patient regarding the
disease and treatment is vital. To assess the knowledge, attitude, practice among patients with hyp Objectives othyroidism
in a tertiary care hospital at Puducherry. The present study was cross sectional study carried out Material and methods among hypothyroid
patients more than 18 years of age attending to the outpatient department, department of general medicine. The study period was 3 months.
Informed consent was obtained from all the participants included into the study. The sample size was estimated to 200. The data was collected in a
semi structured questionnaire. Statistical analysis was done using descriptive statistics. Results 122 (61%) had known the shape of thyroid. 144
(72%) had known the location of thyroid gland. 102 (51%) had known the hormones responsible for hypothyroidism. 84 (42%) had known the
relation between TSH and hypothyroidism. 164 (82%) reported that they took thyroid medications regularly. 130 (65%) reported that they
sometime miss the doses. 148 (74%) reported that they take medication 30 to 60 minutes prior to breakfast. Conclusion With regard to practice,
certain recommended practices like checking TSH levels were poor. Increasing the knowledge in aid in better practice among the participants.
SONOGRAPHIC EVALUATION OF MALE INFERTILITY IN PATIENTS ATTENDING OUTPATIENT DEPARTMENT AT TERTIARY CARE CENTER – AN OBSERVATIONAL CROSS SECTIONAL STUDY
Authors: Sourya V Jay , Vasanthan S Ratna , Reddy Midhusha , Sivarajan Armel Arputha
Published: September 2024

Background: Evaluation of male infertility with clinical examination is less sensitive and specic especially for
assessment of internal reproductive tract, hence imaging forms an integral part of male infertility evaluation. The aim of
this study is to evaluate male infertility using transscrotal and transrectal sonography ndings in infertile male patients and compare the ndings
of varicocele grading and testicular atrophy. A total of 50 infertile male subjects were selected b Methodology: ased on their abnormal seminal
analysis. All the participants were subjected to B-mode ultrasonography of testis and prostate to determine obstructive vs non obstructive cause
of male infertility, along with history taking, physical examination and laboratory investigations including seminal analysis. In the current study
we reported a total of 50 male patients 62 with age ranging from 25-45. In our study, 24 (68%) out Results: of 35 patients with testicular atrophy
had varicocele showing signicant association with average P value of 0.002. 8 patients with post-testicular causes had dilated ductules in the
epididymis, with a P value of <0.001. This study concluded that varicocele is associated with testi Conclusion: cular atrophy and higher the
grades of varicocele more severe is the atrophy. Trans rectal and trans scrotal ultrasound play crucial roles in diagnosing and managing various
urological conditions. Transrectal ultrasound is more focused on the prostate and surrounding structures, while Transscrotal ultrasound is
primarily used for evaluating the scrotum and its contents. Together, these ultrasound techniques provide comprehensive diagnostic capabilities
for male reproductive health.
INTRADIALYTIC ADVERSE EFFECT OF MAINTENANCE HAEMODIALYSIS IN CHRONIC KIDNEY DISEASE PATIENTS.
Authors: Kiruba. K. B Sathiya Sai , Priya. G Lakshmi , K Suresh.
Published: September 2024

Background: haemodialysis was the most common kidney replacement therapy. It was associated with both acute and
chronic complications. Objectives To nd out the adverse events during the maintenance haemodialysis in chronic kidney
disease patients. This observational study was done in 2023 among 160 patients undergoing maintenanc Material and Methods: e hemodialysis
at Sri Venkateshwara Medical College Hospital and Research Institute, Pondicherry. The study was conducted after the approval of the
Institutional Ethics Committee of Sri Venkateshwara Medical College Hospital and Research Institute, Pondicherry. The inclusion criteria were
patients above the age of 18 years and End-stage renal disease patients undergoing maintenance hemodialysis at least twice a week. Informed
consent was obtained from all the participants included in the study. 39% of the participants repor Results: ted having at least one complication.
31.6% had hypotension as a complication followed by 27.5% with muscle cramps. 12.2% had fever and chills and 10.2% had headache. 8.1%
reported to have nausea and vomiting. Hypoglycaemia developed in 4.1% and hypertension in 3.1%. Chest pain was reported by 2.1% and
catheter tip migration in 1.1%. Among those in whom hypotension was a complication, 67.7% had diabetes mellitus followed by 16.1% with
chronic glomerulonephritis. Among those with muscle cramps, 63% had hypertension followed by 18.5% with diabetes. Four in ten Conclusion:
who had undergone haemodialysis had at least one complication. The common complication is hypotension followed by muscle cramps,
DIAGNOSTIC UTILITY OF IMMUNOHISTOCHEMICAL MARKER, p63 IN PROSTATE BASAL CELLS TO DIFFERENTIATE PROSTATE CARCINOMA FROM BENIGN LESIONS OF PROSTATE
Authors: Apeksha Savale , Shilpi Sahu
Published: September 2024

Introduction: Prostate carcinoma (PC) is the fth most common cancer in the world and the is emerging as one of the
leading causes of cancer in both developed and developing countries. Needle core biopsies make it very challenging in
view of small volume of biopsies and presence of benign mimickers of PC. p63, a basal cell marker for prostatic myoepithelial cells are absent in
prostate adenocarcinoma and their identication in prostatic glands can be used to rule out the diagnosis PC. Routine HPE was done Method:
along with IHC with p63 on the tissue sections along with positive and negative controls. Out of 57 Results: samples, 19 cases were neoplastic of
which 1 case was reported as PIN and remaining 18 cases were malignant. 39 cases were reported as benign. The most common mimicker found
was BPH with and without prostatitis accounting to 73.6% cases followed by Basal Cell Hyperplasia and Prostatic Atrophy. 5.8% cases were
missed on H&E but showed negative p63 staining indicating PC and 2.5% of benign mimickers were diagnosed as PC on H&E which showed
strong nuclear positivity of p63 in suspected malignant glands. In our study, benign lesions showed Conclusion: strong basal nuclear positivity of
p63. Malignant cases showed negative nuclear staining in glands but was seen positive in benign glands entrapped in between. The premalignant
lesion showed focal and patchy staining by p63. AMACR showed positive in malignant cells but comparatively weak staining was noted in
adenocarcinomas having cribriform pattern (Gleason pattern 4). Routine H&E still remains to be the gold standard (94.4%) in diagnosing all PC
cases and IHC in an ancillary study done in selected cases only and should not be used as a screening test.
TO STUDY THE RELATION BETWEEN PSEUDOEXFOLIATION AND OPEN ANGLE GLAUCOMA IN PATIENTS VISITING TERTIARY EYE CARE CENTRE
Authors: Girishbhai Patel Kinjal , Jigneshbhai Shah Mansi , Ranmalbhai Rajatiya Yash , Raval Reema
Published: September 2024

Introduction:Pseudoexfoliation syndrome is a systemic condition in which exfoliative material accumulates in organs
other than the anterior structures of the eye, such as the heart, blood vessels, lungs, and meninges. It is frequently
associated with open angle glaucoma, known as pseudoexfoliation glaucoma. Material and Methods:A study of 117
eyes of 77 patients diagnosed with ocular pseudoexfoliation visiting outpatient department of tertiary eye care centre
and who were above 40 years of age was done. The evaluation included age and gender of patients, detailed history,
visual acuity,slit lamp examination,intraocular pressure,pachymetry,visual field analysis and cup-disc ratio evaluation.
Results:In a study period of 2 years,out of total 77 patients,51 (66.23%) patients were male and 26 (33.76%) were female
with mean age of 64.43 years.We observed that 10(15.62%) had mild disc changes, 23(35.93%) had moderate disc
changes, whereas 25(39.06%) had severe disc changes and 35(54.68%) patients had severe field defect whereas only
6(9.37%) had moderate field defect. Out of 117 eyes of 77 patients, 64(54.70%) eyes were diagnosed with glaucoma
whereas 53(45.29%) eyes did not have glaucomatous changes. Conclusions :This study shows positive relation
between pseudoexfoliation and open angle glaucoma. Hence careful eye examination of people having
pseudoexfoliation is mandatory for early diagnosis and treatment of glaucoma which can prevent glaucoma related
visual loss.
PHOTON ENERGY VARIANCE CAUSE OF TEMPERATURE GRADIENT ON ATMOSPHERIC AND SAMPLE MOLECULES
Authors: Vijay L.
Published: September 2024

Photon is a kind of energy that may be visible or invisible,at infrared range we can't see but at visible it seemed.Photon
has no mass it has energy in the range of electromagnetic radiation.Temperature of an object determines the intensity of
electromagnetic radiation.Photons at different frequencies travel like wave nature.When photon hit any matter/material
it get absorbed by same matter and get accentuation hence photon energy slow down while penetrating the
material(material denoted as temperature). Natural atmosphere observation and experimental methods like
absorption spectroscopy used to identify the attenuation coefficient via absorption value. X-ray fluorescence (XRF) is
one such method used to define the elemental composition at the same time one can know excited atomic ions followed
by transition among K shell, L shell and M shell. These transition shows fluorescent spectrum through by one can note
absorption coefficient.Accentuation concept here used to derive novel photon energy equation.
A COMPARISON OF TWELVE ALGORITHMS FOR DIAGNOSING ACCESSORY PATHWAY LOCATION APPLIED IN A CASE SERIES OF PATIENTS WITH WOLFF PARKINSON WHITE SYNDROME
Authors: Prashanth R Gem Raghav , Duraisamy Thilagavathi , Palaniappan Suresh , Radhakrishnan Kannan , Sethumadhavan Raghothaman , Ponnuswamy Suresh Kumar
Published: September 2024

Wolff-Parkinson-White syndrome (WPW), a preexcitation condition characterized by the presence of an accessory
pathway (bypass tract) between the atrium and ventricle.Researchers have developed several algorithms for localizing
the accessory pathway based on 12 lead surface ECGs to date.We aim to compare twelve ECG algorithms,including two
pediatric ones,using a case series of patients with WPW syndrome in this study.The government Chengalpattu Medical
College hospital successfully treated five patients in this case series with radiofrequency ablation. We applied and
compared twelve different algorithms (Milstein, 1987 [5], Fitzpatrick, 1994 [6], St.George, 1994 [7], Chiang, 1995 [8],
D'avila,1995 [9],Arruda,1998 [10],Taguchi,2013 [11],Pambrun,2018 [12],Li H.Y.[13],Baek,2020 [14],Easy WPW,2023
[15], and EPM [16]), including two pediatric algorithms [13, 14]. Among the twelve algorithms, the D'avila, Taguchi,
Pambrun, and Li H.Y. algorithms had the maximum diagnostic accuracy of 100%, followed by 80% with the easy WPW,
Fitzpatrick, and EPM algorithms (Figure 1). In this case series, the Baek algorithm, which is a pediatric algorithm
intended for diagnosing septal pathways,had the lowest accuracy.The other pediatric algorithm,developed by LiH.Y.,
demonstrated superior accuracy compared to the Baek algorithm.To conclude determining the exact pathway location
prior to ablation leads to optimal procedure preparation, maps the pathways that are difficult to locate, and may also
reduce catheter-related injury.In this case series,the algorithms designed by Taguchi,D'avila,Pambrun,and Li H.Y.had
better predictions. Among the two pediatric algorithms, the algorithm by Li H.Y. had better accuracy than the Baek
algorithm.
A COMPREHENSIVE REVIEW OVER MANAGEMENT STRATEGIES AND OUTCOMES IN DUODENAL ULCER PERFORATION
Authors: Ruby Syeda , Awati JIlani , Quddus Mohammed Abdul
Published: September 2024

Introduction: Duodenal perforation is a relatively uncommon yet potentially life-threatening condition, as evidenced
by mortality rates ranging from 8% to 25% in published studies. Recent years have seen a decline in the incidence of
peptic ulcer disease, a trend partly attributed to the widespread use of proton pump inhibitors (PPIs) and effective
eradication treatments for Helicobacter pylori1. Despite these advancements, delayed diagnosis remains a significant
challenge in managing duodenal perforation, often leading to poorer patient outcomes and decreased survival rates.
Methodology: It's a retrospective observational study was conducted between 2023 -2024[1 yr ] including 25 cases
who underwent surgery for duodenal ulcer perforation which were diagnosed intra operatively in department of
General Surgery, Al-Ameen Medical College, Vijayapura. The data provides a comprehensive overview of Results:
patient demographics, surgical procedures, and outcomes, highlighting key trends and distributions in the study
population and demonstrates that the current study aligns well with existing research. In a study involving 25 patients
who underwent intraoperative examination revealing duodenal ulcer perforation, the age range spanned from 19 to 80
years, with the most prevalent age group being 40-49 years. The study population exhibited a male-to-female ratio of 3:1,
comprising 16 males and 9 females. The management strategies for perforated gastro-duodenal ulcers Conclusion:
vary from conservative approaches, first described by Taylor in 1946, to more aggressive surgical options such as
gastrectomy. Typically, the majority of cases are effectively treated with simple suturing of the perforated intestinal wall.
The preferred treatment in many instances involves either open surgical or laparoscopic closure2 of the perforated
ulcer.
A STUDY OF ATHEROGENIC INDEX OF PLASMA IN NON DIABETIC CKD PATIENTS
Authors: T Vinutha , G N Aravind
Published: September 2024

Chronic kidney disease is a silent epidemic of the 21s century. In patients with chronic kidney disease, cardiovascular
disease is the leading cause of morbidity and mortality. Dyslipidemia is one of the complications of CKD and is a leading
cause for cardiovascular complications .Atherogenic index of plasma (AIP) is a novel indicator involved in dyslipidemia
and has been shown to be a strong marker to predict cardiovascular risk.This study was conducted to calculate the AIP in
non diabetic CKD patients and to correlate AIP with various stages of CKD. This study shows that there is negative
correlation between eGFR and AIP values
PRECAUTION AND LEVEL OF SATISFACTION OF CONSTRUCTION WORKERSTOWARDS THEIR WORK ENVIRONMENTS WITH SPECIAL REFORMSOF COIMBATORE DISTRICT
Authors: Gunasekaran B. , S Akshaya
Published: September 2024

A construction worker is someone who is employed as part of a construction crew and will perform many tasks that often
involve physical worker on construction sites. However, there are plenty of roles that don't involve being on a
construction site. The work of building or making something, especially buildings, bridges, He/she works in
construction or in the construction industry. Construction operatives and carry out a range of manual tasks on a
construction site, including preparing ground, driving heavy machinery, moving materials, erecting scaffolding and
carrying out work whilst a project is in progress. The construction industry has the following types of construction
workers based upon their roles: Shuttering Carpenter, General Labor, Steel Fixer, Masons, Plumber, Electrician,
Architect,Construction Supervisor.
PHENYTOIN INDUCED STEVEN JOHNSON SYNDROME ASSOCIATED WITH WHOLE BRAIN RADIATION – EMPACT SYNDROME: A RARE CASE SCENARIO
Authors: Priya S Siva , Kailasam Priyadharsini , John Christopher , Kondavetti Satish Srinivas
Published: September 2024

Phenytoin is commonly utilized as an anticonvulsant for seizure management and prophylactic treatment in brain
metastasis due to its widespread availability and cost-effectiveness. However, among all anticonvulsant medications,
phenytoin carries the highest risk (13%) of development of Steven Johnson syndrome (SJS) or toxic epidermal necrolysis
(TEN). Herein, we present a case report detailing the management of a patient with metastatic breast carcinoma to the
brain, bone, and liver who developed SJS/TEN secondary to phenytoin following whole-brain irradiation (WBI). Timely
recognition of this life-threatening drug-induced complication and prompt withdrawal of the offending agent are crucial
for the survival of patients undergoing anti-epileptic therapy for central nervous system metastasis.
Educación bioeconómica y su complejidad: aprender a vivir en armonía con la naturaleza
Authors:   Universidad de San Carlos de Guatemala, Orellana Aldana Oscar Eduardo
Published: September 2024

PROBLEMA: La actual relación entre los agentes económicos y la naturaleza, bajo el paradigma del modelo productivo occidental orientado al crecimiento económico, está acelerando los procesos de entropía que ponen en peligro la vida en la Tierra. PROPÓSITO: Explicar mediante la biosemiótica y bioeconomía las interacciones entre la sociedad y los ecosistemas naturales, con la finalidad de influir sutilmente en un cambio de conciencia y comportamiento hacia una convivencia más armónica con la naturaleza y promover el biodesarrollo. MÉTODO: Se fundamentó en las teorías de la complejidad y transdisciplinariedad. Se reflexionó sobre la problemática basada en los agentes económicos en interacción con la naturaleza; considerando en los procesos hermenéuticos lecturas, reflexiones y diálogos rizomáticos que mediante la heurística generaron nuevas epistemologías bajo la mirada de los principios del pensamiento complejo, hasta llegar a una síntesis explicativa que respondió a interrogantes expresadas sobre los procesos de educación bioeconómica. APORTE A LA CIENCIA: Esta investigación propone un modelo de educación bioeconómica que busca influir en la conciencia y comportamiento de los agentes económicos y promover una convivencia armoniosa entre sociedad y naturaleza. Se basa en la biosemiótica para comprender los signos y lenguajes de la naturaleza, reconociendo al ser humano como parte integral del entorno biológico y ecológico. Mediante una filosofía simbiocéntrica, genera nuevos conocimientos que priorizan la vida, integrando la biopolítica y la bioética para gestionar la incertidumbre y promover el buen vivir. REFLEXIÓN INCONCLUSA: La educación bioeconómica, conecta disciplinas como la física, economía, biología y ecología, reflexionando en la interdependencia simbiótica entre sistemas humanos y naturales. Promueve un cambio de conciencia y el aprendizaje de nuevos conocimientos, valores y prácticas compartidas, para proteger y cuidar este hogar llamado Tierra, donde vivir bien se traduce en vivir en armonía con toda la diversidad de la vida en un tejido de existencia compartida.
Analyzing Empathetic Discourse in China’s State-Run Youth Media: A Socio-Cognitive Approach
Authors: Song Qijun , Huang Enci , Zhong Yucheng
Published: September 2024

New media empathetic discourses harness the power of digital platforms to achieve empathetic effects, driven by both social cognition and individual psychology. This study focuses on the empathetic discourse on the “Night Thoughts” column of China Youth Daily, a state-run media aiming to foster youth development. Adopting a socio-cognitive approach with positive discourse analysis, this research examines 208 articles published up to December 31, 2023. It identifies three strategies in building the empathetic discourse: relevant mental representation, close discourse order and naturalized social order. Additionally, a “socio-cognitive” model of empathetic discourse is proposed to provide a theoretical reference for future research.
Amazing Pursuit of Traditional Titles in the Nso Fondom of Cameroon in the 20th Century and Impact in the Society; The Case of the Sheey Title
Authors: Bamwai Aurelia Kihla
Published: September 2024

Traditional titles existed before the European Powers colonised Africa in the late 19th century. Cameroon traditional societies were an epitome of every other African society that upheld these titles. In the Nso fondom, Traditional Authorities awarded titles because they realized that it was easy to administer the population with designated individuals charged with the duty of bringing together people to carry out development in the fondom. The acquisition of such titles thus became a sign of honour and prestige to those on whom they were conferred, even though the titles were only awarded to those who distinguished themselves in society either by their achievement or by belonging to a particular lineage. These titles ranged from Kibai, Shuufaay, Faay, Sheey, Yaa, Mfoome etc. During the post-colonial period, the Nso fondom witnessed a proliferation of title holders in the society particularly those of the Sheey class. The desire to uncover the driving force behind this increase prompted this research. Using information from oral and written sources and applying a qualitative and quantitative research methodology, we came up with the findings that the excitement of title award ran and has continued to run in the blood of many people who saw in it an opportunity not only to contribute to the traditional administration of the people and the society as a whole, but also to be noticed. The outcome of this was that title donors disregarded the status quo which required the title to be awarded pursuant to the initial traditional value fervently upheld by the ancestors of the Fondom. Therefore, in order to revive the traditional value of the title, title donors should adhere to the old tradition of award that laid emphasis on maturity and integrity as well as the readiness to act as custodians of the customs and traditions of the Fondom.
Comparative Efficiency between Laparoscopic versus Open Surgery for Inguinal Hernia Repair
Authors: Murad Dr. S M Kamrul Hasan , Rahman Dr. Mohammad Mustafizur , Haque Dr. Md. Mamunul , Kamal Dr. Md Mostafa
Published: September 2024

Background: The lifetime incidence of inguinal hernia is 3% in women and 27% in males. Although surgery is the advised course of action, opinions on the most effective technique are divided. Though there are worries about the possibility of chronic groin pain, open repair is the most common method. The recurrence rate of laparoscopic repair is yet unknown, but it is becoming more and more accepted because of the decreased risk of chronic discomfort. This overview compares the risk of chronic groin pain and recurrence between laparoscopic and open inguinal hernia repairs. Objective: The aim of this study is to assess the comparative efficiency between laparoscopic versus open surgery for inguinal hernia repair. Methods: The cross-sectional observational study was conducted in the Department of Surgery, Avicenna Hospital Limited, Sirajganj, Bangladesh, from July 2022 to June 2023. A total of 50 patients were enrolled and analyzed in this study. The questionnaire was pretested, corrected and finalized. Data were collected by face-to-face interview and analyzed by appropriate computer based programmed software Statistical Package for the Social Sciences (SPSS), version 24. Results: In this study, maximum study patients were in the 41 – 50 years age group. The mean age of the study patients was 41.2 ± 9.2 and 45.1 ± 13.2 years in Laparoscopic surgery and Open surgery group respectively. Most of the patients 22(88.0%) and 23 (92.0%) were male in Laparoscopic surgery group and Open surgery group. About 12 (48.0%) and 8 (32.0%) patients BMI were in between 25.0 – 29.9 kg/m2, 6 (24.0%) and 14 (56.0%) patients BMI in between 18.5 – 24.9 kg/m2 and 7(28.0%) and 3(12.0%) of the patients were overweight (>30 kg/m2) in both Laparoscopic surgery and Open surgery group. Mean ± SD of the study subjects was 25.13 ± 3.12 and 24.02 ± 2.72 years in Laparoscopic surgery and Open surgery group respectively. The period of complaint prior to surgery was 1 – 2 months of 14(56.0%) ..........
PSORÍASE: MUITO ALÉM DA PELE- O IMPACTO SISTÊMICO E PSICOLÓGICO NO PACIENTE COM A DOENÇA IMUNOLÓGICA
Authors: Oliveira Raphael Siza de Oliveira e , Zanuto Thiago Silva , Oliveira Camila Melo de Freitas , Simeão Helena Braule Pinto , Magalhaes Igor Henrique Correia , Andrade Isabela Abud de , Brandão Joana Bader Sadala , Almeida Júlia bobato Ramos de , Jesus Laura Souza de , Luniere Letícia Barroso , Nicolau Luiza Fernanda Mendonça , Almeida Mariana Belo de , Ataides Walace Silva , Ataide Natalia da Silva
Published: September 2024

A psoríase é uma doença inflamatória crônica autoimune, não contagiosa, que afeta cerca de 2 a 5% da população mundial. Influenciada por fatores emocionais, ambientais e genéticos, ela se manifesta por lesões avermelhadas e descamativas, principalmente em placas na pele. A doença envolve a hiperplasia epidérmica e uma resposta imune inadequada, com linfócitos T ativados e macrófagos liberando citocinas como TNF-α, fundamentais no processo inflamatório. A fisiopatologia inclui alterações no queratinócito e na resposta imunológica, com envolvimento de células como queratinócitos e dendríticas, resultando em condições como psoríase vulgar, gutata, eritrodérmica, inversa e palmo-plantar. Tratamentos incluem o uso de emolientes, análogos da vitamina D, metotrexato e imunobiológicos, além de terapias alternativas como a aloe vera, que possui propriedades anti-inflamatórias e cicatrizantes, auxiliando na redução dos sintomas.
IMPACTO DAS MUDANÇAS CLIMÁTICAS NA PREVALÊNCIA DE DOENÇAS DERMATOLÓGICAS
Authors: Arita Sany Tomomi de Almeida Rocha , Fidelis Silva Alayane , Beck Pencinato Nathália , Huguenin Couto Letícia , Spina de Carvalho Márcia , Silva Freitas Leonardo , Dos Santos Ferreira Filho Paulo Henrique , Ferreira de Aguiar Ane Gleyce , De Souza Alvacete Felipe
Published: September 2024

As mudanças climáticas estão se tornando um dos maiores desafios globais do século XXI, impactando diretamente a saúde humana, incluindo a prevalência e severidade de doenças dermatológicas. Fatores como o aumento da radiação ultravioleta, temperaturas elevadas e poluição atmosférica desempenham um papel crucial na incidência de condições cutâneas como câncer de pele, dermatite atópica, infecções e outras doenças inflamatórias da pele. Este estudo visa revisar a literatura atual sobre os efeitos das mudanças climáticas na prevalência de doenças dermatológicas, discutindo implicações para a prática clínica e política de saúde pública. Foi realizada uma revisão integrativa da literatura utilizando as bases de dados PubMed, Scopus e Scielo. Foram incluídos artigos publicados nos últimos cinco anos, em inglês e português, que abordam diretamente a relação entre mudanças climáticas e doenças de pele. Os critérios de inclusão contemplaram estudos com dados quantitativos e qualitativos sobre os impactos climáticos na saúde dermatológica, excluindo-se artigos sem foco específico em dermatologia. A análise dos dados coletados foi descritiva e comparativa, considerando fatores ambientais como poluição, radiação UV e variações de temperatura. A revisão revelou um aumento significativo na prevalência de câncer de pele, particularmente melanoma, em áreas com maior exposição à radiação ultravioleta. Além disso, doenças inflamatórias crônicas da pele, como dermatite atópica, mostraram-se mais frequentes e severas em regiões com altos níveis de poluição atmosférica. Houve também um aumento na incidência de infecções cutâneas, associado a mudanças nos padrões de precipitação e aumento da umidade. Os dados indicam que populações vulneráveis, como crianças e idosos, são as mais afetadas pelas alterações ambientais. As mudanças climáticas têm um impacto significativo e crescente nas doenças dermatológicas, exacerbando a incidência e gravidade de várias condições cutâneas. A implementação de políticas de saúde pública voltadas para a prevenção e adaptação a esses impactos, incluindo proteção solar, controle da poluição e vigilância de doenças infecciosas, é essencial. Dermatologistas desempenham um papel fundamental na conscientização e no manejo clínico desses pacientes frente às mudanças ambientais.
Painel epidemiológico dos óbitos por eclâmpsia na mulheres brasileiras entre 2019 e 2021
Authors: Falcão Vidotti Ana Laura , Carvalho Tacão Letícia , de Oliveira Moreira Paulo Henrique , Asonuma Teixeira Thainá , Peixoto Lopes Talita , Fernandes Martins Manuella , Bernardes Henriques Amaral Ana Luiza , Brito de Almeida Neto Tibiriçá , Lopes Gonçalves Gilberto , Mafra de Oliveira Ítalo
Published: September 2024

A eclâmpsia é uma complicação severa da pré-eclâmpsia caracterizada por convulsões em mulheres grávidas sem histórico de distúrbios convulsivos, ocorrendo geralmente após a 20ª semana de gestação e podendo persistir após o parto. É um estado crítico que afeta tanto a mãe quanto o feto, sendo mais comum em gestações múltiplas e mulheres com histórico de hipertensão ou doença renal. A eclâmpsia é uma causa significativa de mortalidade materna mundialmente, incluindo no Brasil, onde variações na prevalência refletem disparidades no acesso à saúde e qualidade do atendimento pré-natal. O objetivo deste estudo é analisar os óbitos por eclâmpsia em mulheres brasileiras entre 2019 e 2021, buscando identificar padrões geográficos, fatores de risco prevalentes e relações com outras comorbidades para orientar políticas públicas e estratégias de prevenção. Foi realizada uma análise epidemiológica quantitativa e retrospectiva com dados do Sistema de Informação sobre Mortalidade (SIM), usando o software Microsoft Excel 2019 para manipular e analisar variáveis demográficas e clínicas. A pesquisa utilizou dados secundários de domínio público, não requerendo submissão ao Comitê de Ética em Pesquisa. O estudo revelou que entre 2019 e 2021 houve uma flutuação nos óbitos por eclâmpsia no Brasil, com maior incidência na região Nordeste e entre mulheres na faixa etária de 30 a 34 anos. Etnias com maior número de óbitos incluíram mulheres pardas e amarelas, e a maior parte dos óbitos ocorreu em hospitais. A discussão nos estudos destacou que a eclâmpsia é uma condição com complexa fisiopatologia envolvendo disfunção endotelial e vasoconstrição devido à hipertensão. Os fatores de risco como idade materna avançada, obesidade, e fatores socioeconômicos como baixo nível educacional são significativos. A necessidade de uma abordagem preventiva e de melhorias no sistema de saúde para reduzir a mortalidade por eclâmpsia foi enfatizada. Este estudo sublinha a importância de políticas públicas eficazes e campanhas educacionais para melhorar o reconhecimento e o tratamento da pré-eclâmpsia e eclâmpsia. A colaboração entre diferentes setores é crucial para mitigar os riscos e melhorar os desfechos de saúde materna, promovendo maior equidade no acesso a recursos de saúde essenciais e uma abordagem multidimensional que considere as especificidades socioculturais das mulheres afetadas.
A PANDEMIA PASSA: REFLEXÕES SOBRE O LUTO E AS PERDAS VIVIDAS DURANTE A PANDEMIA.
Authors: Marinho Lúcia de Fátima Pereira Leite , Santos Isabella Peixoto Dos , Alencar Helena Côrtes De , Silva Ana Beatriz Farias , Melo Maria Clara Pontoja , De Castro Ana Beatriz Ferreira , Nunes Roseli Barbosa , Silva João Henrique dos Santos
Published: September 2024

A pandemia da COVID-19 trouxe uma onda de desafios e mudanças profundas para toda a humanidade. Entre os muitos impactos, o luto se destacou como uma experiência universal, embora vivenciada de maneiras únicas. As restrições sanitárias, o isolamento social e a ausência de rituais tradicionais de despedida complicaram ainda mais o processo de luto, criando um cenário onde a dor da perda foi, muitas vezes, exacerbada pela impossibilidade de se despedir adequadamente. O objetivo deste estudo é explorar e compreender as diferentes dimensões do luto experimentado durante a pandemia, analisando como as circunstâncias excepcionais influenciaram a maneira como as pessoas processaram suas perdas. A análise revelou que o luto vivido durante a pandemia foi marcado por um profundo senso de isolamento e interrupção. A impossibilidade de realizar rituais tradicionais de despedida, como funerais e velórios, deixou muitas pessoas sem a oportunidade de compartilhar sua dor e encontrar conforto na presença de entes queridos. Entretanto, o estudo também evidenciou a resiliência humana, com muitas pessoas encontrando novas formas de expressar seu luto e buscar apoio, seja por meio de tecnologias digitais ou pela criação de novos rituais de lembrança. À medida que a pandemia recua, é fundamental que as sociedades reconheçam o impacto duradouro do luto e das perdas vividas durante esse período. Integrar o entendimento dessas experiências na saúde mental coletiva e promover espaços de escuta e acolhimento será crucial para a recuperação emocional e para a reconstrução de uma vida mais plena e conectada. A reflexão contínua sobre essas experiências permitirá transformar a dor em aprendizado, fortalecendo as relações humanas e a capacidade de enfrentar adversidades futuras.
Análise epidemiológica do perfil das hospitalizações por traumatismo cranioencefálico no Brasil de 2019 a 2023
Authors: Lopes de Sena Rafael , Ramos Rezende Estella , Lemos Schuch Karolina , Araújo Brilhante Mayara , Lopes Araújo Daniel
Published: September 2024

O Traumatismo Cranioencefálico (TCE) é uma das principais causas de morbimortalidade, especialmente entre adultos jovens. Apresentando repercussões de longo prazo, caracteriza uma problemática de saúde pública que demanda maior conhecimento dos dados demográficos brasileiros. Frente à escassez de estudos epidemiológicos nesse sentido, o presente estudo objetiva oportunizar a melhor compreensão da temática por meio da análise espaço-temporal das hospitalizações por TCE entre 2019 e 2023. Para isso, foram coletados dados do Sistema de Informações sobre Morbidade Hospitalar do SUS (SIM), com base nas variáveis de faixa etária, sexo, cor/raça e localização geográfica por regiões do Brasil. Os resultados evidenciaram um crescente aumento nos registros de internações, sendo o pico em 2023 e a maior prevalência de casos em todo o período na região Sudeste (58,72%), acometendo em maior número pessoas do sexo masculino (75,45%), pardas (44,66%) e entre 20 e 29 anos. Tais achados corroboram as análises de pesquisas epidemiológicas anteriores no que diz respeito às variáveis demográficas, bem como propiciam inferir possíveis relações de causalidade, especialmente no que diz respeito à predominância observada quanto aos dados de sexo, idade e cor/raça, considerando sua relação com os grupos descritos na literatura como mais vulneráveis às lesões cranioencefálicas. Ainda assim, estudos futuros precisam ser conduzidos a fim de avaliar possíveis casos de subnotificações dos grupos que apresentam menores taxas de internação, apesar de serem considerados suscetíveis ao TCE (como idosos e mulheres); e com o objetivo de elucidar as causas da disparidade verificada na distribuição epidemiológica do território brasileiro quanto à localidade e à época do ano.
El papel del ecocardiograma en pacientes con epidermólisis ampollosa.
Authors: Zaruma Balseca Ninna Jesahel , Erazo Verdugo Entza Sariri , Almeida Vera Mishell Nataly , Paucar Rodriguez Ariana Carolina , Maya Cobo Xavier Alejandro , Tapia Silvers Carmen Del Rocio , Parrales Herrera Miguel Angel , Valarezo Ramirez Johanna Del Rocio , Vivanco Vivanco Maria Fernanda , Arboleda Gordillo Yeremi Suleyma , Baquerizo Herrera Roxana Elizabeth , Nuñez Jimenez Agustin Andres
Published: September 2024

Introducción: La epidermólisis ampollosa (EA) es una enfermedad genética rara, caracterizada por la fragilidad de la piel y membranas mucosas, con grados de severidad variados. Este trabajo explora las complicaciones cardíacas en EA, su evaluación mediante ecocardiograma y su manejo multidisciplinario. Objetivo: Explorar el papel del ecocardiograma en la evaluación y manejo de pacientes con EA, enfocado en las complicaciones cardíacas.  Metodología: Se realizó una búsqueda exhaustiva en bases de datos como PubMed y Scopus, focalizada en estudios recientes sobre EA y ecocardiograma. Se seleccionaron estudios que abordaran complicaciones cardíacas y el uso del ecocardiograma en estos pacientes. Resultados y Discusión: Diversos estudios han identificado miocardiopatía dilatada, arritmias y otras anomalías cardíacas en pacientes con EA. El ecocardiograma permite la detección temprana de estas complicaciones, crucial para su manejo. Los estudios indican alteraciones en la función diastólica y siastólica, subrayando la importancia del monitoreo regular. Conclusión: La EA presenta complicaciones cardíacas significativas. El ecocardiograma es vital para su detección y manejo, mejorando el pronóstico y la calidad de vida de estos pacientes. Es necesario un enfoque multidisciplinario y más investigaciones para optimizar la gestión de estas complicaciones.