bluuebunny/crossref_metadata_2025 huggingface dataset:
Table 3 from The Prostaglandin EP4 Antagonist Vorbipiprant Combined with PD-1 Blockade for Refractory Microsatellite-Stable Metastatic Colorectal Cancer: A Phase Ib/IIa Trial
Authors: Pietrantonio Filippo , Morano Federica , Niger Monica , Ghelardi Filippo , Chiodoni Claudia , Palazzo Michele , Nichetti Federico , Manca Paolo , Cristarella Eleonora , Doldi Valentina , Zaffaroni Nadia , Sabella Giovanna , Brambilla Nadia , Benincasa Elena , Giacovelli Giampaolo , Vitalini Cristina , Girolami Federica , Rovati Lucio C.
Published: February 2025

Summary of best overall responses and DCR.
Supplementary Table S6 from Genomic Profiling Reveals SMARCA4 Mutations Are Associated with Shorter Overall and Intracranial Progression-Free Survival in Patients with Melanoma Brain Metastases
Authors: Fischer Grant M. , Lamba Nayan , Vogelzang Jayne , Aizer Ayal , Ligon Keith L.
Published: February 2025

Supplementary Table S6. Extracranial metastasis samples from patients who developed brain metastases and post-brain metastasis diagnosis survival information.
Supplementary Figures S1-S21 from Genomic Profiling Reveals SMARCA4 Mutations Are Associated with Shorter Overall and Intracranial Progression-Free Survival in Patients with Melanoma Brain Metastases
Authors: Fischer Grant M. , Lamba Nayan , Vogelzang Jayne , Aizer Ayal , Ligon Keith L.
Published: February 2025

Supplementary Figures S1-S21
Supplementary Figure S4 from Smoking-Associated Carcinogen–Induced Inflammation Promotes Lung Carcinogenesis via IRAK4 Activation
Authors: Aggarwal Ritesh K. , Sidoli Simone , Wang Jingli , Sahu Srabani , Sanawar Rahul , Gupta Varun , Aluri Srinivas , Sukrithan Vineeth , Vegivinti Charan T.R. , Zavras Phaedon D. , Verma Divij , Gordon-Mitchell Shanisha , Agarwal Beamon , Verma Tanya , Starczynowski Daniel T. , Steidl Ulrich G. , Shastri Aditi , Halmos Balazs , LaFave Lindsay M. , Cheng Haiying , Verma Amit , Zou Yiyu
Published: February 2025

Supplementary Figure S4. Immunofluorescence using CD68 Cy5 on mouse lung tissues harvested after 18 months of intratracheal treatment. Magenta stain represent Cy5 stain on CD68 antibody and blue represent nuclear counterstain DAPI. Left, representative image for intratracheal PBS administration. Right, representative image for mice administered NB (NNK and BaP).
Supplemental Figure 1 from Histologic and Immunologic Factors Associated with Response to Immune Checkpoint Inhibitors in Advanced Sarcoma
Authors: Lee Alex Q. , Hao Clara , Pan Minggui , Ganjoo Kristen N. , Bui Nam Q.
Published: February 2025

Supplemental Figure 1
Supplemental Figure 2 from Phase I/II Trial of Exportin 1 Inhibitor Selinexor plus Docetaxel in Previously Treated, Advanced KRAS-Mutant Non–Small Cell Lung Cancer
Authors: von Itzstein Mitchell S. , Burns Timothy F. , Dowell Jonathan E. , Horn Leora , Camidge D. Ross , York Sally J. , Eaton Keith D. , Kyle Kelly , Fattah Farjana , Liu Jialiang , Mu-Mosley Hong , Gupta Arjun , Nadeem Urooba , Gao Ang , Zhang Song , Gerber David E.
Published: February 2025

Supplemental Figure 2. Transcriptional signatures identified through RNA sequencing.
Table S14 from Multiomics Reveals the Immunologic Features and the Immune Checkpoint Blockade Potential of Colorectal Medullary Carcinoma
Authors: Liu Chao , Zou Haoyi , Ruan Yuli , Fang Lin , Wang Bojun , Cui Luying , Wu Tong , Chen Zhuo , Dang Tianjiao , Lan Ya , Zhao Wenyuan , Zhang Chunhui , Meng Hongxue , Zhang Yanqiao
Published: February 2025

Supplementary Table 14. GO results between MeC and nMeC
Figure S1 from Multiomics Reveals the Immunologic Features and the Immune Checkpoint Blockade Potential of Colorectal Medullary Carcinoma
Authors: Liu Chao , Zou Haoyi , Ruan Yuli , Fang Lin , Wang Bojun , Cui Luying , Wu Tong , Chen Zhuo , Dang Tianjiao , Lan Ya , Zhao Wenyuan , Zhang Chunhui , Meng Hongxue , Zhang Yanqiao
Published: February 2025

sFigure 1. DNA alterations in colorectal medullary carcinoma.
Table S12 from Multiomics Reveals the Immunologic Features and the Immune Checkpoint Blockade Potential of Colorectal Medullary Carcinoma
Authors: Liu Chao , Zou Haoyi , Ruan Yuli , Fang Lin , Wang Bojun , Cui Luying , Wu Tong , Chen Zhuo , Dang Tianjiao , Lan Ya , Zhao Wenyuan , Zhang Chunhui , Meng Hongxue , Zhang Yanqiao
Published: February 2025

Supplementary Table 12. Information for oncoplot according TES
Figure S2 from Multiomics Reveals the Immunologic Features and the Immune Checkpoint Blockade Potential of Colorectal Medullary Carcinoma
Authors: Liu Chao , Zou Haoyi , Ruan Yuli , Fang Lin , Wang Bojun , Cui Luying , Wu Tong , Chen Zhuo , Dang Tianjiao , Lan Ya , Zhao Wenyuan , Zhang Chunhui , Meng Hongxue , Zhang Yanqiao
Published: February 2025

sFigure2. Description about biological function by transcriptional analysis.
Data from Genomic Profiling Reveals SMARCA4 Mutations Are Associated with Shorter Overall and Intracranial Progression-Free Survival in Patients with Melanoma Brain Metastases
Authors: Fischer Grant M. , Lamba Nayan , Vogelzang Jayne , Aizer Ayal , Ligon Keith L.
Published: February 2025

AbstractPurpose:
Melanoma brain metastases (MBM) are a common and lethal complication of metastatic melanoma. Despite improvements in treatments, subsets of patients with MBM experience rapid clinical decline, and currently, few prognostic biomarkers have been identified. An improved understanding of the molecular features specifically associated with MBM overall survival (OS) and intracranial progression-free survival (PFS) could facilitate the development of more effective clinical management strategies.
Experimental Design:
We established an initial cohort of 102 MBMs, 970 unmatched melanoma extracranial metastases (ECM), and 569 unmatched melanoma primaries with available targeted exome sequencing data covering 182 genes and a validation cohort of 50 MBMs with SMARCA4 genomically profiled. Kaplan–Meier analysis, log-rank test, and Cox proportional hazards model were used to evaluate associations between pathogenic genomic alterations and OS and intracranial PFS. We evaluated 14 MBMs and 19 ECMs with paired RNA sequencing and whole-exome sequencing data to identify genotype–transcriptome correlations.
Results:
Of 43 genes significantly mutated among MBMs, only pathogenic mutations in SMARCA4 significantly associated with shorter OS and intracranial PFS on univariable and multivariable analyses in patients with MBM but not from first ECM or primary tumor diagnosis. SMARCA4 mutations significantly associated with enrichment of oxidative phosphorylation and depletion of immune signaling gene sets.
Conclusions:
Pathogenic SMARCA4 mutations independently predict an association with shorter OS and intracranial PFS in patients with MBM and associate with expression of pathways known to mediate melanoma virulence. These findings add to our understanding of MBM pathogenesis and suggest their potential use as prognostic biomarkers in patients with MBM and possible therapeutic opportunities.
Data from A Phase I Study of FHD-609, a Heterobifunctional Degrader of Bromodomain-Containing Protein 9, in Patients with Advanced Synovial Sarcoma or SMARCB1-Deficient Tumors
Authors: Livingston J. Andrew , Blay Jean-Yves , Trent Jonathan , Valverde Claudia , Agulnik Mark , Gounder Mrinal , Le Cesne Axel , McKean Meredith , Wagner Michael J. , Stacchiotti Silvia , Agresta Samuel , Quintás-Cardama Alfonso , Reilly Sarah A. , Healy Kathleen , Hickman Denice , Zhao Tina , Ballesteros-Perez Alex , Khalil Alexis , Collins Michael P. , Piel Jessica , Horrigan Kim , Lefkovith Ariel , Innis Scott , Lazar Alexander J. , Cote Gregory M. , Wagner Andrew J.
Published: February 2025

AbstractPurpose:
FHD-609, a potent, selective, heterobifunctional degrader of bromodomain-containing protein 9 (BRD9), was evaluated for treating patients with advanced synovial sarcoma or SMARCB1-deficient tumors.
Patients and Methods:
In this multinational, open-label, phase I study (NCT04965753), patients received FHD-609 intravenously at escalating doses either twice weekly (5–80 mg; n = 40) or once weekly (40–120 mg; n = 15).
Results:
Fifty-five patients received FHD-609 for a median of 43 days. The maximum tolerated doses were 40 mg twice weekly and the equivalent weekly dose, 80 mg once weekly. Dose-limiting toxicities of QTc (heart rate–corrected QT interval) prolongation and syncope were observed at 40 and 60 mg twice weekly. Treatment-related adverse events were predominantly grades 1 to 2 in severity, most commonly dysgeusia (40%), dry mouth (29.1%), fatigue (27.3%), and anemia (25.5%). Eleven (20%) patients had treatment-emergent QTc (Fridericia formula) prolongation preceded by T-wave inversions; 21 (38.2%) patients had T-wave inversions without further cardiac events or ECG abnormalities. FHD-609 showed dose-dependent increases in pharmacokinetic exposure, with no substantial accumulation. Extensive BRD9 degradation in tumor tissue corresponded to the downregulation of cancer cell proliferation gene sets. One (2%) patient achieved a partial response; eight (15%) patients achieved stable disease, which lasted longer than 6 months in two patients.
Conclusions:
FHD-609 showed dose-dependent increases in systemic FHD-609 exposure and pharmacodynamic response profiles. The maximum tolerated doses were identified (40 mg twice weekly/80 mg once weekly) and preliminary clinical activity was observed. Future studies of BRD9 degraders will require strict cardiac monitoring given the QTc prolongation observed in this study.
Data from Circulating Tumor DNA Dynamics and Clinical Outcome in Metastatic Colorectal Cancer Patients Undergoing Front-Line Chemotherapy
Authors: Ghidini Michele , Hahne Jens Claus , Senti Chiara , Heide Timon , Proszek Paula Z. , Shaikh Ridwan , Carter Paul , Hubank Mike , Trevisani Francesco , Garrone Ornella , Cappelletti Maria Rosa , Generali Daniele , Cattaneo Monica , Gnocchi Nicoletta , Donati Gianvito , Gobbi Angela , Grizzi Giulia , Lampis Andrea , Elghadi Raghad , Tanzi Giulia , Tomasello Gianluca , Ratti Margherita , Pinato David J. , Fassan Matteo , Vlachogiannis Georgios , Sottoriva Andrea , Cortellini Alessio , Passalacqua Rodolfo , Valeri Nicola
Published: February 2025

AbstractPurpose:
We tested whether circulating tumor DNA (ctDNA) changes may be used to assess early response and clinical outcomes in patients with metastatic colorectal cancer (mCRC) undergoing first-line systemic anticancer therapy (SACT).
Experimental Design:
Eight hundred sixty-two plasma samples were collected 4-weekly from baseline (BL) until disease progression in patients with mCRC receiving first-line SACT. ctDNA was tested using tissue-agnostic next-generation sequencing panels. ctDNA normalization was defined as ≥99% clearance after 1 month of therapy (Mo1) in the three variants with the highest allele frequency in BL ctDNA.
Results:
Eighty-three paired samples from 75 patients were available for analysis. Twelve pairs (14.4%) showed no variants in either BL or Mo1. In the remaining 71 comparisons (65 patients), 37 (52.1%) showed ctDNA normalization at Mo1. Patients who cleared ctDNA had significantly longer overall (45.6 months) and progression-free survival (13.9 months) compared with nonnormalized patients [overall survival = 22.6 months (log-rank P = 0.01) and progression-free survival = 10.7 months (log-rank P = 0.036), respectively]. In addition, a higher response rate was observed in patients with ctDNA clearance (72.9%) compared with nonnormalized cases (38.2%). Longitudinal sequencing of at least four time points in patients with a progression-free survival of >10 months showed emerging variants in 47.8% of cases; in all these patients, the trajectory of these new “outlier” variants seemed in stark contrast with the clinical–radiological course of disease and the trend in other mutations.
Conclusions:
ctDNA clearance represents an early indicator of benefit from SACT in patients with mCRC; serial tracking of multiple variants is warranted to improve specificity and avoid misleading information due to the emergence of mutations of unknown clinical significance.
SIRT2 regulates the SMARCB1 loss-driven differentiation block in ATRT
Authors: Alimova Irina , Wang Dong , DeSisto John , Danis Etienne , Lakshmanachetty Senthilnath , Prince Eric , Murdock Gillian , Pierce Angela , Donson Andrew , Balakrishnan Ilango , Serkova Natalie , Lin Hening , Foreman Nicholas K. , Dahl Nathan , Venkataraman Sujatha , Vibhakar Rajeev
Published: February 2025

Atypical teratoid rhabdoid tumor (ATRT) is a highly aggressive pediatric brain tumor driven by the loss of SMARCB1, which results in epigenetic dysregulation of the genome. SMARCB1 loss affects lineage commitment and differentiation by controlling gene expression. We hypothesized that additional epigenetic factors co-operate with SMARCB1 loss to control cell self-renewal and drive ATRT. We performed an unbiased epigenome targeted screen to identify genes that co-operate with SMARCB1 and identified SIRT2 as a key regulator. Using in vitro pluripotency assays combined with in vivo single cell RNA transcriptomics, we examined the impact of SIRT2 on differentiation of ATRT cells. We employed a series of orthotopic murine models treated with SIRT2 inhibitors to examine the impact on survival and clinical applicability. We found that ATRT cells are highly dependent on SIRT2 for survival. Genetic or chemical inhibition led to decrease cell self-renewal and induction of differentiation in tumor spheres and in vivo models. We found that SIRT2 inhibition can restore gene expression programs lost due to SMARCB1 loss and reverse the differentiation block in ATRT in vivo. Finally, we showed the in vivo efficacy of a clinically relevant inhibitor demonstrating SIRT2 inhibition as a potential therapeutic strategy. We concluded that SIRT2 is a critical dependency in SMARCB1 deficient ATRT cells and acts by controlling the pluripotency-differentiation switch. Thus, SIRT2 inhibition is a promising therapeutic approach that warrants further investigation and clinical development. Implications: SIRT2 inhibition is a molecular vulnerability in SMARCB1-deleted tumors.
A reflective analysis of the Losarang-Indonesian Dayak community’s thinking culture in selecting a life partner
Authors: Mellawaty Mellawaty , Sukestiyarno Yohanes Leonardus , Isnarto Isnarto , Zaenuri Zaenuri
Published: February 2025

This research uses a realistic ethnographic design to examine the culture of mathematical thinking in determining the match between partners for marriage in the Losarang-Indonesian Dayak community. Data were collected through field notes, in-depth interviews, and observation. Ethnomathematics as a research genre reveals important universal elements of mathematical activity, while ethnomodelling reflects ideas and the practice of community mathematics through ethical, emic, and dialectical approaches. The findings of this research indicate that ethnomathematically, the Losarang-Indonesian Dayak community have used formal language on mathematical principles to develop a knowledge system capable of sorting, pairing, calculating, and comparing the suitability of partners based on birth. Ethnomodelling is a relevant mathematical idea and concept related to arithmetic operations, sets, relations, functions, and number comparisons. Furthermore, the implication of this research is to produce didactic situations to teach the concepts of arithmetic operations, sets, relations as well as functions, and number comparisons. The didactic situation of the customary patterns of the Losarang-Dayak community can also be presented in mathematics teaching materials based on local culture. Therefore, the successful conduction of this research can enrich the repertoire of developing school mathematics learning that focuses on local culture.
Opportunities and challenges while conducting field trips to the museum: a narrative review
Authors: Sahani Chatterjee , Prakasha G. S.
Published: February 2025

The museum visit field trip engages and motivates the children in various activities. Field trips to the museum provide the students with a constructivist and experiential learning environment as they construct knowledge through observing the artifacts. The present study describes the possible opportunities and challenges for school children while conducting field trips to the museum. The study employed a narrative review technique to address the research question raised. The study selected the literature reviews from 2012-2023, including studies on field trips to the museum for the academic engagement of school children. The data includes 50 peer-reviewed journal articles categorized into five categories: students’ overall development, experiential learning opportunities, the museum as a resource, the role of teachers, the school, and museum authority. Results revealed that the museum is a resource for learning and is perfect for improving students’ cognitive and affective development towards the various school subjects and helping them enhance their participatory learning opportunities. However, teachers’ knowledge, infrastructure, parental consent, and legitimization with the school authority are some challenges in conducting museum visit field trips. Future research may focus on conducting empirical studies, which include school-museum collaboration, to enhance the horizon of school and community knowledge.
Identifying challenges of cultivating creativity in product design
Authors: Suradin Salwa , Rasul Mohamad Sattar , Omar Marlissa
Published: February 2025

Creativity, a crucial skill in the fourth industrial revolution (IR4.0) is highly demanded in the workforce to drive innovation in product design. Therefore, it is important to cultivate creativity in product design through design and technology (D&T) education. However, many past studies encountered challenges regarding D&T teachers’ teaching creativity which might affect creativity cultivation among students. Thus, this article aims to identify the challenges faced by D&T teachers in cultivating student creativity within product design development. Utilizing the systematic literature review (SLR) method using reporting standards for systematic evidence syntheses (ROSES) in three databases, Web of Science, Scopus, and Google Scholar. Based on thematic analysis, this SLR leads to three themes: i) lack of pedagogical competence; ii) different thinking styles; and iii) lack of motivation. Addressing these challenges highlights the importance for educational institutions to align their curricula with current industry demands, ensuring students are well-prepared to tackle the complexities of contemporary product design. This effort requires collaboration among educators, industry leaders, and policymakers to update teaching methods, incorporate practical experiences, and enhance an environment that cultivates creativity.
Shaping competence of intercultural communication during the COVID-19
Authors: Ayazbayeva Saya , Mukushev Bazarbek , Yessekeshova Maral
Published: February 2025

Shaping intercultural communication competencies during the educational process in higher education institutions is a crucial criterion for modern global education. This study considers using digital learning technologies in foreign language teaching as an efficient pedagogical strategy for developing intercultural communicative competence during the COVID-19 pandemic. The research methodology was based on a pedagogical experiment. A total of 43 students from the People’s Republic of China, Kyrgyz Republic, Republic of India, and Turkmenistan participated in three study groups. Before the experiment, the indicators of digital competence and willingness to engage in intercultural communication were low, with a high correlation between them. During the one-year academic experiment, the students studied foreign languages using digital technologies. They were involved in cultural immersion programs, master’s classes on intercultural communication, language exchange programs, virtual intercultural events, and online cultural resources. This contributed to improving intercultural communication and, at the same time, students’ digital competence.
Quizizz-online gamification on learning engagement and outcomes in English lecturing process
Authors: Rokhaniyah Hesti , Ardiyanti Dwi , Hidayat Nurul
Published: February 2025

Gamification entails incorporating elements of games into non-game settings with the goal of motivating learners to actively participate in learning. Much literature highlighted the potential of gamification in enhancing learning interest; however, very few researches delved gamification of Quizizz online for learning grammar. This research explored the effects of Quizizz on learning engagement and outcome while studying grammar. This study involved English lecturer and 68 learners in the second semester of a private university in Ponorogo, Indonesia. The data in this research was analyzed using a qualitative approach through classroom-based ethnography, including lecturer interviews, observations, and scrutiny of Quizizz test performances. The interpretation involved examining trends in learners' engagement and mean scores of Quizizz tests. The results of the research indicated that the competitive features in Quizizz such as rankings and limited time enhanced their engagement, marked by increased discipline and active involvement. Nevertheless, the fluctuation in learning outcomes was observed due to variations in topic difficulty, particularly evident with topic 1 (conjunction) being less challenging compared to the more difficult topics 2 (subject-verb agreement) and 3 (passive voice). Topic 2, characterized by its complexity, posed the greatest difficulty, emphasizing the importance of customizing quiz difficulty levels to optimize the effectiveness of Quizizz in the learning process.
Digital learning models: experience of online learning during the pandemic
Authors: Muzayanah Umi , Maknun Moch Lukluil , Sa'ad Faidus , Mustolehudin Mustolehudin , Taruna Mulyani Mudis
Published: February 2025

During the global pandemic of COVID-19, the learning model has been “forced” to transition from conventional to distance learning. At the beginning of its implementation, digital-based learning received many complaints from teachers, parents, and students. Gradually, they can adapt to distance learning that utilizes many digital devices. Through quantitative and qualitative research approaches, this paper aims to describe the online learning model in schools and Islamic boarding school (pesantren) based on their experience during COVID-19. From these studies, several digital-based learning models can be identified. First, social media-based learning. Social media-based learning is carried out by optimizing the use of WhatsApp as the main media in learning. Second, learning through virtual classrooms, which is face-to-face learning between teachers and students in a digital space. Third, education platform-based learning, where the learning process is conducted through internal school or government platforms. Fourth is blended learning, which is learning partly online and offline. This fourth lesson aims to accommodate the learning needs of students or teachers who have obstacles such as signal difficulties and weak economies. The findings contribute to the availability of references for digital learning models that can be applied in the future.
Exploring the development of front office instructional module from the experts’ opinions
Authors: Quah Wei Boon , Sulaiman Tajularipin , Razali Fazilah
Published: February 2025

In the world of hospitality, the front office plays a crucial role as it is the first point of contact for guests entering a hotel. This makes front office operation (FOO) a vital subject in hospitality education programs, especially at community colleges. While there is a growing body of research on FOO, there's a lack of instructional modules designed specifically for community college students. To address this gap, a study was conducted to understand the need for developing a FOO module based on expert opinions. Using the analyze, design, develop, implement, and evaluate (ADDIE) framework, data from three experts were analyzed. Educators cited issues such as limited practice time, communication skill hesitancy, and struggles with term comprehension and pronunciation. Meanwhile, students encountered obstacles like inadequate practical equipment, unsupportive learning environments, and overwhelming syllabi. Nonetheless, educators acknowledged the potential of a FOO instructional module to enhance student learning experiences. This study emphasizes the significance of crafting a tailored module for community college students, paving the way for advancements in hospitality education.
Impact of external demands problems on students’ psychological well-being: systematic literature review
Authors: Setiawan Muhammad Andi , Estimurti Endang Sri , Pantiwati Yuni , Latipun Latipun , Bulkani Bulkani , In'am Akhsanul , Hudha Atok Miftachul
Published: February 2025

Students’ well-being is often disturbed by external demands, such as academic pressure, family expectations, and social expectations. These demands can impact students’ mental and emotional well-being. This research aims to explore the problems of external demands for students’ psychological well-being. This research used the systematic literature review (SLR) method to investigate the impact of external demands on students’ psychological well-being. Data were collected from articles published between 2018 and 2023 from the Scopus database. Of the 93 articles, 26 articles were obtained after screening. Data mining and analysis were conducted with the help of Publish or Perish, Biblioshiny, and ATLAS.ti. The results show the complexity of external demands, with factors such as internal and external support, job control, social media use, and individual differences in emotion regulation playing essential roles. The long-term impacts of these demands can include increased levels of stress, anxiety, and depression in students. Therefore, it is essential to manage external demands strategically to create a learning environment that supports students’ psychological well-being. This research highlights the need for joint efforts between schools, families, and communities to address external demands on students. Effective interventions are needed to reduce the negative impact of external demands.
IT education: impact assessment of a multi-fold approach
Authors: Radaideh Moh’d A. , Abu Al-Haija Qasem
Published: February 2025

This study addresses the benefits and challenges of implementing a multi-faceted hybrid approach to delivering an introductory information technology (IT) course at Jordan University of Science and Technology, Jordan. We conducted a questionnaire survey with 251 participants, utilizing Google Forms for data collection and Microsoft Excel 2016 for coding. Data analysis was performed using SPSS statistics 17.0. Most participants were male students aged 21-23, pursuing bachelor’s degrees across various departments, with network engineering and security (NES) being the most represented. The survey items exhibited good internal consistency (Cronbach’s alpha=0.778), and significant associations were found among variables (p-value<0.05). Strengths of the hybrid approach include flexibility, instructor responsiveness, and engaging online resources. However, areas for improvement were identified in online discussion forums, such as technology tool usability, workload management, communication clarity, and assessment transparency. Despite challenges, the study underscores the successful implementation of the hybrid approach in IT course delivery, supported by positive student perceptions and recommendations for future adoption.
Online teaching style: insights of faculty and students’ perspectives and student engagement
Authors: Padmaja Goteti Venkata , Malay Jhancy , Sultana Juveria , Rangraze Imran Rashid , Harshita Chilakalapalli Ramya
Published: February 2025

Medical education had a paradigm shift to online learning during COVID 19 pandemic. The studies conducted identify the benefits and limitations of online learning but not much studies on the faculty and students’ perceptions of faculty online teaching style and the degree of online student engagement. The study was done at Kakatiya Medical College, India. At the end of one year of online teaching to the novice foundation year students during lockdown period, the faculty and students’ perceptions on faculty’s online teaching styles and degree of student engagement were recorded using teaching style inventory (TSI) and online student engagement questionnaire. The study found that 60% of the faculty and 42% of the students perceived that the faculty adopted collaborative teaching style, thus the perception difference was significant (p=0.05). The perception of other teaching styles such as suggestive, assertive, and facilitative among faculty and students were different but statistically not significant. Students positively engaged when faculty practiced facilitative and collaborative teaching styles. To conclude, facilitative, and collaborative, teaching methods help medical students’ motivation for online engagement. Medical students were better engaged with online instruction when instructors gave prompt responses to questions, insightful criticism of work, and individualized coaching.

 
The readiness of mathematics teachers as agents of change: a recent comprehensive review
Authors: Abu Talib Sharida , Mohamad Nasri Nurfaradilla , Mahmud Muhammad Sofwan
Published: February 2025

This study scrutinizes the role of mathematics teachers as pivotal agents of change in the evolving educational landscape, focusing on their readiness to embrace pedagogical reforms. The review aims to reveal the current patterns and trends in mathematics teachers’ readiness literature discussed in recent studies. Utilizing the preferred reporting items for systematic reviews and meta-analyses (PRISMA) framework, this study analyzed 31 empirical articles from the Scopus and Web of Science databases in 2023. The review process for chosen articles is examined, encompassing aspects such as publication criteria, eligibility and exclusion standards, databases, and the progression of review stages. The most striking result from the analysis is that mathematics teachers’ readiness is closely related to teaching strategies and pedagogy. Moreover, inconsistencies in practice and constraints such as inadequate resources, insufficient institutional support, and teacher training program gaps hinder their ability to implement change effectively. The implications of this study extend to various stakeholders in the education ecosystem, including policymakers, educational institutions, teacher training programs, and practitioners. This review suggests strategies to enhance teachers’ professional development and serve as preliminary work toward developing a pedagogy model. In conclusion, this systematic review consolidates the existing knowledge on the readiness of mathematics teachers as agents of change.
A ten-year bibliometric study on mathematical ability
Authors: Gusteti Meria Ultra , Musdi Edwin , Dewata Indang , Fauzan Ahmad , Arnawa I Made , Rasli Amran Md.
Published: February 2025

Mathematical ability is a crucial aspect of modern life as it influences various fields such as economics, technology, and science. This study, spanning 2014-2023, examines articles on mathematical ability in leading journals. Using the bibliometric methods, it includes article searches in Scopus and Google Scholar via Publish or Perish (PoP), classification for bibliometric analysis, metadata checks, and bibliometric analysis using VOSviewer. The research shows a consistent trend in publications on mathematical ability, with minimal fluctuations and significant citation patterns. High-citation articles underscore the field’s importance in knowledge advancement. Key terms are ‘ability’, ‘mathematical ability’, and ‘student’, indicating research focus areas. However, limited author collaboration suggests potential for increased interdisciplinary synergy and knowledge sharing. These findings highlight opportunities for enhancing cross-disciplinary collaborations and research networks. They offer insights for policymakers, educators, and researchers in understanding trends, developing effective learning strategies, and encouraging further research in mathematical ability. In summary, this bibliometric study provides a comprehensive overview of the significance of mathematical ability in research, emphasizing the need for collaborative, innovative educational and research practices. It underscores the importance of further research to deepen understanding and application of mathematical ability, promoting an integrative approach in this essential field.
Accounting education from 1960 to 2023: a bibliometric review
Authors: Hu Guojing , Muhamad Haslinah , Mustafa Hasri , Alhasnawi Mushtaq Yousif
Published: February 2025

Since 1960, publications in accounting education have demonstrated a high level of productivity and influence. However, few studies have attempted to use bibliometric methods to map and visualize accounting education research. This study aimed to identify global issues in accounting education through bibliometric analysis, covering the period from 1960 to 2023, by exploring publication trends, top topics, and major contributors in the field. Tools such as Microsoft Excel, VOSviewer, the bibliometric R-package, and WordSift were utilized to comprehensively analyze 717 Scopus-indexed documents. The findings underscore a continuous and recently accelerated historical evolution of accounting education publications, with primary research areas clustering around “business, management, and accounting.” Noteworthy trends include a geographic concentration in the United States, the United Kingdom, and Australia, with RMIT University emerging as a key contributor. Hassell, from the United States, is recognized as the most influential author, and “accounting education” from Taylor & Francis stands out as the most productive journal. Works by Bui and Porter in 2020 emerge as the most frequently cited documents. The research results indicate that future research directions should focus on students, higher education, and the profession, emphasizing themes such as curriculum, learning, and skills.
The impact of revenue structure on the financial performance of general colleges and universities in China
Authors: Yuyan Hou , Halim Hazianti Abdul , Basri Mohd Faizal
Published: February 2025

Despite the continuous increase in total funding for general colleges and universities in China, these institutions face challenges related to insufficient educational funds and inefficient fund utilization, leading to suboptimal financial performance. Therefore, the main purpose of this study is analyzing their revenue structures, which comprise the proportion of financial subsidy revenue, career revenue and other revenue and to examine the impact of revenue structures on their financial performance (measured by talent cultivation, scientific research, and social services). This study builds linear regression models and combines panel data of general colleges and universities from 2010 to 2021 to study the impact of revenue structure on their financial performance. The findings indicate that the revenue of general colleges and universities in China is based mainly on financial subsidy revenue, with the proportion of such revenue increasing annually. The financial performance of these institutions also predicates an increasing trend. Most importantly, regression analysis shows that financial subsidy revenue has a positive impact on financial performance, whereas career revenue and other revenue negatively impact financial performance. Thus, Chinese general colleges and universities should prioritize increasing financial subsidy revenue while carefully managing career and other revenue to enhance financial performance.
Fostering integrity among school principals’ ethical leadership: a comprehensive systematic review
Authors: Ak Bujang Mackencidy , Alias Bity Salwana , Mansor Azlin Norhaini
Published: February 2025

This systematic review explores the importance of promoting integrity in the ethical leadership of school principals, particularly when ethical lapses by educational leaders can impact outcomes. Increasing societal pressures and a complex educational environment highlight the importance of ethical leadership in shaping the school environment and student success. However, the lack of a complete understanding of how to effectively create ethical leadership remains a major concern. An extensive search of scholarly articles was conducted from reputable databases such as Scopus, Web of Science, and ERIC, focusing on studies published between 2020 and 2024. The flow of study based on PRISMA framework. The database found (n=19) final primary data was analyzed. The finding was divided into three themes which is academic integrity and ethics in education, leadership and integrity in educational management, and character and value education in schools. Comprehensive programs and administrative support are essential to fostering integrity in schools, while effective leadership plays an important role in shaping a conducive school environment. In conclusion, the need to foster integrity among school principals across disciplinary boundaries requires concerted efforts and innovative approaches to prepare ethical leaders to navigate the complexities of the contemporary educational landscape and inspire positive change.
Unveiling the role of organizational commitment on job satisfaction and job performance in Islamic education
Authors: Yaakob Mohd Faiz Mohd , Habibi Akhmad , Halili Siti Hajar , Abdullah Hamdy , Yaqin Lalu Nurul , Alqahtani Turki Mesfer , Fauzee Mohd Sofian Omar
Published: February 2025

This study evaluates the influences of organizational commitment components on job satisfaction and job performance among Islamic boarding school (IBS) teachers. It also aimed to decide the mediating effect of job satisfaction on the relationship between organizational commitment and job performance. This comparative study compares the path coefficient between exogenous and endogenous constructs based on respondents’ countries, Malaysia and Indonesia. Through a simple random sampling, the data were gathered from 247 respondents. The analysis was conducted through partial least square structural equation modeling (PLS-SEM) approaches (measurement model, structural model, and multi-group analysis). The measurement model informed that the obtained data was valid and reliable. The structural model examination reports that normative and continuance commitment strongly predict job satisfaction. Similarly, continuance commitment and job satisfaction are significant predictors of job performance. As a mediator, job satisfaction successfully mediates the relationships between continuance commitment and job performance and between normative commitment and job performance. No significant differences emerge from the multi-group analysis results between IBS teachers from Kedah (Malaysia) and Jambi (Indonesia), regarding all direct paths between the constructs. This article provides knowledge contributions from Indonesia and Malaysia, in the context of Islamic education.
Predicting personalized mathematics learning among pre-university students in the Maldives
Authors: Mohamed Mausooma , Ayub Ahmad Fauzi Mohd , Yasin Maizura , Nawi Nur Raihan Che
Published: February 2025

The use of learning management systems (LMS), such as Moodle, for personalized mathematics learning (PML) is successful; nonetheless, its performance depends on several factors. This study investigates the factors influencing the utilization of LMS for PML at the Maldives National University (MNU). A correlational study was conducted involving 120 randomly selected pre-university students using an online questionnaire to measure performance expectancy (PE), effort expectancy (EE), social influence (SI), facilitating conditions (FC), and student commitment (SC) toward LMS usage behavior (UB). Data analysis with IBM statistical package for the social sciences (SPSS) statistics version 25.0 revealed significant positive relationships between LMS UB and PE (r=0.624**), EE (r=0.644**), FC (r=0.533**), and SC (r=0.696**), with SC being the strongest predictor. SI showed a weaker positive relationship (r=0.204). The study also discovered a multiple correlation (R) value of 0.807 and an analysis of variance (ANOVA) (F (5, 114)=42.497, p=0.000). The study’s findings underscore the significance of these factors in promoting LMS adoption and effective use concluding that focusing on these key predictors can enhance PML and improve student engagement and performance.
Investigation of the factors affecting students’ self-directed learning readiness in the blended learning model
Authors: Bich Nguyen Thi , Thuy Kieu Phuong , Mai Huong Vu Thi , Binh Pham Thi
Published: February 2025

Many factors influence the level of readiness for self-directed learning. This study seeks to examine the relationship between learners’ personal characteristics (gender, major, academic year), external factors (facilities, self-study time, peer influence, teacher support), internal factors (cognitive skills, metacognitive skills, attitudes, motivation), and self-directed learning readiness in a blended learning model. The aim is to identify the decisive influencing factors to promote learners’ readiness for self-directed learning and improve blended teaching effectiveness. A survey was conducted with 1,276 students participating in the blended learning model at Hanoi National University of Education in Vietnam. The data were quantitatively analyzed using structural equation modeling with the partial least squares approach in SmartPLS 3, as well as regression analysis in SPSS 20. The findings showed that external factors accounted for 68.7% of the variation in internal factors and 41.6% of the variation in self-directed learning readiness. The study also found that factors such as major and academic year had significant impacts on self-directed learning readiness, as evidenced by statistically significant differences with p-values less than 0.05. These results suggest strategies for educators to effectively address these factors to enhance students’ self-directed learning readiness in blended learning environments.
Examining GenAI readiness and behavioral intention of adult learners: a PLS-SEM and IPMA approach
Authors: Chan Josephine Ie Lyn , Tan Saw Fen , Chew Meng Cheng
Published: February 2025

In the current rapidly changing technological landscape, emerging technologies such as generative artificial intelligence (GenAI) continue to disrupt adult learners’ preparedness for the AI-driven future in the workplace and in society. This study aimed to explore the factors of adult learners’ behavioral intention towards adopting GenAI. A quantitative approach was used where a self-administered online survey was randomly distributed to existing adult learners at an open and distance learning (ODL) institution in Malaysia. There were 484 responses, however, due to straightlining and outlier issues, only 460 were usable. Data analysis used SPSS version 28 for data cleaning and descriptive statistics, and SmartPLS 4 to perform partial least squares structural equation modelling (PLS-SEM) and the assessment of importance-performance matrix analysis (IPMA). The findings indicated that GenAI readiness constructs of ability and ethics positively predict adult learners’ intention to adopt GenAI. Management of the university should address the performance gap in ability, maintain ethical awareness, and improve the performance of vision and cognition.
The effect of convenience and self-efficacy on the satisfaction of learning management system usage
Authors: Zulherman Zulherman , Mansor Abu Bakar Ahmad , Kulgemeyer Christoph
Published: February 2025

Universities widely use the learning management system (LMS) technology due to its flexibility and ease of use for lecturers when managing online learning with the LMS. The primary determinant of success is the admittance of students utilizing this technology based on the LMS. However, institutions have challenges when utilizing LMS systems. The study aims to evaluate the factors that impact student satisfaction (SS) when using the LMS. The study methodology employs the Delone McLean model technique, incorporating the elements of convenience (Co) and self-efficacy (SE) into the survey. Data was gathered from a sample of 178 undergraduate students. The data analysis conducted using structural equation modeling (SEM) partial least squares (PLS) entailed the testing of six hypotheses. The results found that only three hypotheses were supported: information quality (IQ) and system quality (SQ) had a positive impact on SS. Student satisfaction also harmed the use of LMS (LU). This research contributes to the knowledge that internal and external factors of the LMS system also play an important role in the satisfaction of LMS usage.
A qualitative case study of constructivist teaching at a high school in a northern area of Vietnam
Authors: Oanh Pham Thi Kieu , Van-Trao Nguyen , Thi Mai Nguyen Huong
Published: February 2025

This study aims to identify the English high school teachers’ beliefs at a high school in the northern region of Vietnam regarding constructivist teaching (CT) and their actual classroom practices (CP). This paper summarizes results from a five-year Ph.D. study conducted with seven high-school English teachers within a qualitative case study research design with the help of three data collection instruments, including semi-structured and Stimulated recall interviews and direct classroom observations. Thematic analysis using MAXQDA was chosen for data analysis. The findings uncovered themes that emerged from the data, which might lay the foundation for classifying teachers into three groups: adaptive originators (AOs), neutral pragmatists (NPs), and traditional conservers (TCs). Most TCs’ teaching philosophies were teacher-centered and supportive of conventional teaching techniques. Still, the NPs acknowledged that instructional strategies needed to be changed. The AOs sought to change how teachers used CT; they actively put strategy into place to bring about meaningful change. These results were valuable references for high school teachers to assist their students with better constructivist instruction, thus enhancing the quality of teaching and learning English in the 4.0 era.
Digital resources and learning outcomes in college physical education: a survey study
Authors: Yu Jingnan , Song Wenlong
Published: February 2025

The effectiveness of digital resources in teaching remains a widely debated issue, particularly in the field of physical education. This article aims to examine the impact of digital resource learning on the learning outcomes of undergraduate physical education courses, with a specific focus on the role of students’ awareness and competence in using digital resources. Using a questionnaire survey method, the study analyzed data from 310 undergraduate students from five universities in China. The results showed that digital use ability, use awareness and resource environment had a significant positive effect on satisfaction with learning outcomes. Digital usage awareness fully mediated the effect of digital learning confidence on learning outcome satisfaction and partially mediated the effect of digital usage ability and resource environment on learning outcome satisfaction. These findings suggest that enhancing students’ digital usage awareness and learning confidence can significantly improve learning outcomes in physical education courses. The article recommends that educators better utilize and refine digital resources in teaching and enhance students’ digital learning skills and awareness to improve the effectiveness of physical education teaching. This study enriches the content of the digital teaching model, reveals the intrinsic mechanisms of how digital resource learning affects learning outcomes, and provides new insights and methods for improving the teaching effectiveness of physical education courses.