bluuebunny/crossref_metadata_2025 huggingface dataset:
Electrochemical properties of roots determine antibiotic adsorption on roots
Authors: Liu Yuan , Tao Zhen , Lu Hailong , Li Siyi , Hu Chao , Li Zhongyang
Published: March 2023

The adsorption behaviors and transfer pathways of antibiotics in plant–soil system are greatly influenced by the electrochemical properties of both soil particles and plant roots. However, the effects of roots electrochemical properties on antibiotic adsorption are largely unknown. Here, the fresh soybean, maize, and wheat roots with different electrochemical properties were obtained from hydroponic cultivation, and the adsorption processes and mechanisms of doxycycline, tetracycline, sulfadiazine, and norfloxacin on roots under various environmental conditions were investigated. Results showed that the adsorption amount of antibiotics on roots increased with the initial concentration of antibiotics. The coexisting low–molecular weight organic acids and anions inhibited the antibiotic adsorption on roots. The soybean roots performed strong adsorption ability compared with the maize and wheat roots driven by the variations in root electrochemical properties. This study demonstrates the significance of electrochemical interactions between antibiotics and roots in plant–soil system and can contribute to the more accurate risk assessment and effective pollution control of antibiotics.
An encounter with the self: A thematic and content analysis of the DMT experience from a naturalistic field study
Authors: Michael Pascal , Luke David , Robinson Oliver
Published: March 2023

Introduction

N,N-Dimethyltryptamine (DMT) is an endogenous serotonergic psychedelic capable of producing radical shifts in an experience that have significant implications for consciousness and its neural correlates, especially given the “disconnected consciousness” suggested by the “breakthrough” DMT state. Its increasing usage and clinical trial indicate the growing importance of a thorough elucidation of the experience's qualitative content, over and above the phenomenological structure. This is particularly in light of the intensely pervasive effects of DMT occasions in all dimensions of the self, which are often ontologically challenging yet potentially transformative.

Methods

This is the second report on the first naturalistic field study of DMT use exploring its qualitative analysis. Screened, healthy, anonymized, and experienced DMT users were observed during their non-clinical use of the drug at home (40–75-mg inhaled). In-depth semi-structured interviews, inspired by the micro-phenomenological technique, were employed immediately after their experience. This study reports on the thematic and content analysis of one major domain of the breakthrough experiences elicited, the “self”; where analyses of the “other” were previously reported. A total of 36 post-DMT experience interviews with mostly Caucasian (83%) men (eight women) of a mean of 37 years were predominantly inductively coded.

Results

Invariably, profound and highly intense experiences occurred. The first overarching category comprised the onset of effects, encompassing super-ordinate themes including sensory, emotion and body, and space-time shifts; the second category comprised bodily effects, encompassing themes including pleasurable, neutral/both, and uncomfortable; the third category comprised the sensorial effects, encompassing open-eye, visual, and cross-modal and other; the fourth comprised the psychological effects, encompassing memory and language, awareness and sense of self, and time distortions; and the fifth comprised the emotional effects, encompassing positive, neither/both, and challenging experiences. Many further subthemes also illuminate the rich content of the DMT experience.

Discussion

The present study provides a systematic and nuanced analysis of the content of the breakthrough DMT state pertaining to one's personal and self-referential experiences of the body, senses, psychology, and emotions. The resonances both with previous DMT studies and other types of extraordinary experiences, such as the alien abduction, shamanic and near-death experiences, are also elaborated upon. Putative neural mechanisms and their promise as a psychotherapeutic agent, especially owing to deep emotional impact, are discussed.
Carer involvement in the assessment of personal recovery: A naturalistic study of assertive community treatment in Norway
Authors: Israel Pravin , Ruud Torleif , Weimand Bente
Published: March 2023

Background

The user and carer movements have come a long way in becoming embedded in mainstream mental health services for individuals with serious mental illness. However, implementing recovery-oriented practice continues to be plagued by an individualistic clinical focus. The carers do not feel integrated despite policies and best intentions. The implementation of Assertive Community Treatment (ACT) provided an opportunity to involve the carers and compare their assessment of personal recovery with the users.

Aims

The aims of this study were to examine (i) how family carers and users differed in their assessment of personal recovery, (ii) whether familial and personal relationships influenced how carers assess personal recovery of users, and (iii) if the experience of family carers with the ACT team was associated with personal recovery.

Methods

The naturalistic, explorative study recruited 69 users and 36 family carers from 12 Norwegian ACT teams. The users and carers assessed the user's personal recovery. Family carers also reported their experience and satisfaction with the ACT teams. Analyses included independent and paired sample T-tests and correlation analysis.

Results

Family carers were significantly more conservative than the users' assessment of the intrapsychic and interpersonal subscales of personal recovery. The pattern held true whether the family carers were matched to the users or part of the total sample. Lastly, there was a significant negative correlation between the family carer's experience of cooperation with the ACT team and their assessment of the user's intrapersonal process of recovery.

Conclusions

The results of our study were consistent with previous research on carer involvement in MHS. However, it is the first study that engaged carers and assessed personal recovery of the users of ACT services. Discrepancy between carers and users is the rule. Clinicians are encouraged to embrace the discrepancy and diversity carers bring and learn the methodology of multi-informant assessments. There also is a need to address, update, and integrate the personal, familial, and relational aspects of recovery. Modification of recovery measures such as QPR and their creative use with carers has the potential to generate valuable third-party information and to involve them meaningfully in mental health services.
Exploring the relationship between air quality and health shocks to the elderly: A retrospective cross-sectional study in China
Authors: Li Xinyu , Lyu Yanxia , Dong Wanyue , Xu Aijun
Published: March 2023

Methods

We selected 5,172 microdata on individuals from the China Health and Retirement Longitudinal Study (CHARLS) 2018. The binary logit model, the ordered logit model, and the stepwise regression were employed to compare the effects of air pollution on self-rated health (SRH) and activities of daily living (ADL) in an elderly population. The effects on health shocks were explored in different age groups, different gender groups, different regions and different sources of pollutants, respectively.

Results

We found that air pollution significantly increased the risk of health shocks in the elderly population, especially in the 60–69 year age group, and the eastern/central region, where NO2 and O3 were important pollutant sources.

Conclusion

Targeted management of the environment is necessary to improve the health status of China's elderly population. In addition, paying attention to the health status of vulnerable populations is needed to achieve social equity.
A Keynesian perspective on the health economics of kidney transplantation would strengthen the value of the whole organ donation and transplantation service
Authors: Leonardis Francesca , Gitto Lara , Favi Evaldo , Oliva Angelo , Angelico Roberta , Mitterhofer Annapaola , Cacciola Irene , Santoro Domenico , Manzia Tommaso Maria , Tisone Giuseppe , Cacciola Roberto
Published: March 2023

Background

In this study, the Keynesian principle “savings may be used as investments in resources” is applied to Kidney Transplantation (KT), contextualizing the whole Organs Donation and Transplantation (ODT) service as a unique healthcare entity. Our aim was to define the financial resources that may be acquired in the form of savings from the KT activity.

Methods

We analyzed registry and funding data for ODT in our region, between 2015 and 2019. Our hypotheses aimed to evaluate whether the savings would offset the Organ Donation (OD) costs, define the scope for growth, and estimate what savings could be generated by higher KT activity. To facilitate the evaluation of the resources produced by KT, we defined a coefficient generated from the combination of clinical outcomes, activity, and costs.

Results

The ODT activity reached a peak in 2017, declining through 2018–2019. The savings matured in 2019 from the KT activity exceeded €15 million while the OD costs were less than €9 million. The regional KT activity was superior to the national average but inferior to international benchmarks. The estimated higher KT activity would produce savings between €16 and 20 million.

Conclusion

The financial resources produced by KT contribute to defining a comprehensive perspective of ODT finance. The optimization of the funding process may lead to the financial self-sufficiency of the ODT service. The reproducible coefficient allows a reliable estimate of savings, subsequently enabling adequate investments and budgeting. Applying such a perspective jointly with reliable estimates would establish the basis for an in-hospital fee-for-value funding methodology for ODT.
Correlation of fundamental movement skills with health-related fitness elements in children and adolescents: A systematic review
Authors: Liu Cong , Cao Yuxian , Zhang Zhijie , Gao Rong , Qu Guofeng
Published: March 2023

Objective

To examine the correlations between fundamental movement skills and health-related fitness elements (cardiopulmonary function, flexibility, body composition, muscle strength and endurance) in children and adolescents and investigate the evaluation methods and tools of fundamental movement skills and health-related fitness.

Methods

Six electronic databases (Web of Science, PubMed, ProQuest, Scopus, EBSCO and CNKI) were searched, and the research literature on the correlation between children's and adolescents' fundamental movement skills and health-related fitness published since 2002 was collected. The guidelines of the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement and the Consolidated Standards of Reporting Trials (CONSORT) statement were used to evaluate the quality of the literature, and the sources, samples, measurement methods, main results and statistical data of the study were analyzed, summarized and discussed.

Results

After applying the inclusion and exclusion criteria, 49 studies were included. There were 13 tools for evaluating fundamental movement skills and 4 tools for evaluating comprehensive health-related fitness in the included literature. Sufficient research evidence supports a significant positive correlation between fundamental movement skills and cardiopulmonary function (10, 100%) and muscle strength and endurance (12, 100%), and most studies support the positive correlation between fundamental movement skills and flexibility (4, 66.7%), and the significant negative correlation between fundamental movement skills and body composition (29, 67.4%). Studies used skinfold, AF%, BF%, FM, and FFMI as evaluation methods. They showed a consistently significant negative correlation between body composition and fundamental movement skills (9, 100%), while BMI or waist circumference as evaluation methods showed no consistent significant negative correlation result (20, 58.8%). Moreover, in the sub-item evaluation of fundamental movement skills, object manipulation, locomotor and balance skills were all significantly and positively correlated with cardiopulmonary function and muscle strength and endurance. In contrast, locomotor skills were more closely related to body composition than object manipulation skills.

Conclusion

A significant correlation exists between children's and adolescents' fundamental movement skills and health-related fitness elements.
Platform workers and digital agency: Making out on three types of labor platforms
Authors: Alasoini Tuomo , Immonen Jere , Seppänen Laura , Känsälä Marja
Published: March 2023

Much of the research on platform workers has focused on individuals involved in low-skilled and highly standardized tasks. However, platform workers are not a homogeneous group. Utilizing a classification system that makes a distinction between different layers of platform control and grouping platforms according to how they divide decision rights between platforms and workers, we examine how and for what purposes platform workers operating in three types of control contexts have practiced and developed their digital agency for making out. The study, based on an analysis of platform webpages and 32 semi-structured interviews of food couriers, freelancers, and interim managers, shows that workers can exercise their digital agency on all three types of platforms, but different platforms create different conditions for this depending on their special forms of control. In addition, the forms of control also affect to what extent workers are motivated to direct their agency for making out. Instead of regarding platform work as just another layer of a periphery segment in the labor market, our analysis suggests that platforms exercising algorithmic control are new types of arenas for work, which seem to reproduce, or even amplify, the inequalities found in the offline world of work in the digital world.
A review on experimental surgical models and anesthetic protocols of heart failure in rats
Authors: Farag Ahmed , Mandour Ahmed S. , Hendawy Hanan , Elhaieg Asmaa , Elfadadny Ahmed , Tanaka Ryou
Published: March 2023

Heart failure (HF) is a serious health and economic burden worldwide, and its prevalence is continuously increasing. Current medications effectively moderate the progression of symptoms, and there is a need for novel preventative and reparative treatments. The development of novel HF treatments requires the testing of potential therapeutic procedures in appropriate animal models of HF. During the past decades, murine models have been extensively used in fundamental and translational research studies to better understand the pathophysiological mechanisms of HF and develop more effective methods to prevent and control congestive HF. Proper surgical approaches and anesthetic protocols are the first steps in creating these models, and each successful approach requires a proper anesthetic protocol that maintains good recovery and high survival rates after surgery. However, each protocol may have shortcomings that limit the study's outcomes. In addition, the ethical regulations of animal welfare in certain countries prohibit the use of specific anesthetic agents, which are widely used to establish animal models. This review summarizes the most common and recent surgical models of HF and the anesthetic protocols used in rat models. We will highlight the surgical approach of each model, the use of anesthesia, and the limitations of the model in the study of the pathophysiology and therapeutic basis of common cardiovascular diseases.
Betaine and nano-emulsified vegetable oil supplementation for improving carcass and meat quality characteristics of broiler chickens under heat stress conditions
Authors: Suliman Gamaleldin M. , Hussein Elsayed O. S. , Al-Owaimer Abdullah N. , Alhotan Rashed A. , Al-Garadi Maged A. , Mahdi Jameel M. H. , Ba-Awadh Hani A. , Qaid Mohammed M. , Swelum Ayman Abdel-Aziz
Published: March 2023

Introduction

This research aimed to examine the effects of water-added betaine (BET) and/or nano-emulsified vegetable oil (MAGO) on carcass and meat quality characteristics of broilers raised under thermoneutral (TN) and heat stress (HS) conditions.

Methods

On day 21, 640 birds (Ross 308) were randomly assigned to one of two thermal conditions (thermoneutral 22 ± 1°C and heat stress 32 ± 1°C) each containing four treatment groups: Control, BET, MAGO, and a mixture of both (BETMAGO) in a 2 × 4 factorial arrangement (eight groups). Each group has eight replicates, with ten birds each. The birds' carcass and meat quality characteristics were evaluated at 35 days.

Results and discussion

The dressing percentage, breast, leg, wing, heart, initial pH, color change, cooking loss (CL), water-holding capacity (WHC), shear force (SF), and texture profile with exception of springiness significantly affected by the treatments. The results showed that HS had negative effects on carcass weight and relative weights of the breast, spleen, and heart. Moreover, HS increased dressing percentage, wing, initial pH, final core temperature, initial lightness, WHC, and hardness. Significant differences in interactions between treatments and temperature were observed in the spleen, WHC, and SF.

Conclusion

Water supplemented with BET effectively improved carcass dressing percentage, breast weight, and meat quality in terms of water-holding capacity and tenderness under HS conditions. More studies on the use of BET and/or MAGO at different levels were recommended.
Prevalence of Disordered Eating and Its Associated Factors From a Socioecological Approach Among a Sample of Spanish Adolescents: The EHDLA Study
Authors: López-Gil José Francisco , Jiménez-López Estela , Fernández-Rodríguez Rubén , Garrido-Miguel Miram , Victoria-Montesinos Desirée , Gutiérrez-Espinoza Héctor , Tárraga-López Pedro J. , Mesas Arthur Eumann
Published: March 2023

Objectives: The aim of this study was twofold: a) to establish the prevalence of adolescents with disordered eating and b) to determine the factors associated with this prevalence in a sample of Spanish adolescents from the Valle de Ricote (Region of Murcia, Spain).

Methods: This cross-sectional study analyzed data from 730 adolescents (56.2% girls) from the EHDLA study. To determine the prevalence of disordered eating, the Sick, Control, One stone, Fat, Food (SCOFF) questionnaire was used. A socioecological approach was used to identify individual-, interpersonal-, or organizational-level factors associated with disordered eating.

Results: The prevalence of disordered eating was 30.1%. This condition was associated with female sex (odds ratio [OR] = 2.60; 95% confidence interval [CI], 1.81–3.73), immigrant status (OR = 2.22; 95% CI, 1.51–3.25), or excess weight (OR = 2.74; 95% CI, 1.93–3.89). Furthermore, for each additional hour slept, lower odds of having disordered eating were found (OR = 0.81; 95% CI, 0.67–0.98).

Discussion: Almost one-third of the sample of Spanish adolescents analyzed reported disordered eating. Female sex, immigrant status and excess weight are individual aspects that seem to be related to disordered eating among Spanish adolescents.
Blow-Up Dynamics and Synchronization in Tri-Trophic Food Chain Models
Authors: Takyi Eric M. , Parshad Rana D. , Upadhyay Ranjit Kumar , Rai Vikas
Published: March 2023

Synchronization of food chain models is an intensely investigated area in dynamical systems. Two pioneering models in three species food chain systems exhibiting chaotic dynamics are the Hastings and Powell (HP) model and the Upadhyay and Rai (UR) model. These are known to synchronize, even though the top predators in the two models behave differently. In the current manuscript, we show that although the HP and UR models synchronize for certain initial conditions, they do not synchronize for arbitrarily large initial conditions due to the blow-up dynamics present in the UR model. Thus, the synchronization of these model systems is purely a local (in initial data) phenomenon. Interestingly, we find that a similar result holds for the modified UR model as well, which has global in-time solutions for any positive initial condition. Thus, the lack of synchrony could also be attributed to the difference in the top predator’s feeding preferences in the model systems. Our results have large-scale applications to population synchrony in tri-trophic food chains.
Uncalibrated Adaptive Visual Servoing of Robotic Manipulators with Uncertainties in Kinematics and Dynamics
Authors: Lai Guanyu , Liu Aoqi , Yang Weijun , Chen Yuanfeng , Zhao Lele
Published: March 2023

In the study, we propose a novel adaptive visual servoing control scheme for robotic manipulators with kinematic and dynamic uncertainties, where the camera used is uncalibrated, which implies that its intrinsic and extrinsic parameters are unavailable for measurement. For our scheme, a depth-independent composite Jacobian matrix is constructed to make visual parameters and robotic physical parameters appear linearly in a parametrized uniform form so that an adaptive algorithm can be developed to estimate their values. With the raised adaptive algorithm, the potential singularity of the Jacobian matrix can be well circumvented by updating estimated parameters in an appropriate tiny range of actual values. With our scheme, the asymptotic convergence of the image tracking error to zero is established successfully, in addition to the signal boundedness of the closed-loop system. The effectiveness of the proposed scheme is confirmed by simulation results based on a 6-DOF PUMA manipulator.
Relationship between Changes in the Business Environment, Innovation Strategy Selection and Firm’s Performance: Empirical Evidence from Slovenia
Authors: Gošnik Dušan , Kavčič Klemen , Meško Maja , Milost Franko
Published: March 2023

This article studies the relationship between changes in the external business environment, a firm’s innovation strategies towards customers, and performance. A model of relations was developed, as well as a hypothesis: “The use of the differentiation strategy has a positive effect on firm’s performance. SMEs that use the differentiation strategy achieve better performance than those who use one of the other strategies (low-cost strategy, focus strategy, or an overtaking strategy)”. The empirical study includes a population of 3007 SMEs and a sample of 163 SMEs. The firm’s performance was measured using financial measures such as return on equity (ROE) and return on assets (ROA), operational measures such as economic value added (EVA) and comprehensive measures such as credit rating (CR). The structural equation modelling (SEM) approach was used for data analysis. Based on the results, we can confirm that changes in a firm’s external environment affect the firm’s strategy towards customers, which influences the performance of a firm. The empirical study confirmed that firms using the differentiation strategy indicate higher performances (ROA, EVA, and CR) than those using any other strategy. Results also show that high-performance SMEs incorporate customer perspectives into strategy selection. The most significant influence on the firm’s selection of the differentiation strategy was found in cases when the firm cooperates with new customers with whom it has not collaborated thus far. SMEs that use a low-cost strategy, focus strategy, or overtaking strategy are less successful than companies that use a differentiation strategy. The developed model of relations in this research has special meaning for researchers and managers in the field of strategic management, strategy selection and implementation, as well as performance of SMEs.
Gust Response of Spanwise Morphing Wing by Simulation and Wind Tunnel Testing
Authors: Yao Zhuoer , Kan Zi , Li Daochun
Published: March 2023

The spanwise morphing wing can change its aerodynamic shape to suit its flight environment, thereby having the potential to improve the flight performance of the aircraft, especially in gusty conditions. To investigate the potential of morphing wings, the aerodynamic performance of a spanwise morphing wing with a flapping wingtip in a gust environment was analyzed in this paper. The aerodynamic characteristics of the morphing wing are hard to measure accurately, and thus a wind tunnel test was carried out to study the influences of morphing parameters, such as the morphing length, amplitude and frequency on the gust alleviation effect. The flow mechanism of the designed spanwise morphing wing was analyzed in detail by the instantaneous lift results of the wind tunnel test and the flow field results of the CFD method. The results have shown that with appropriate morphing parameters, the spanwise morphing wing designed in this paper can effectively achieve gust alleviation during flight. The conclusions obtained in this paper can be useful guidance for the design of morphing aircraft.
Lighting in Dark Periods Reduced the Fecundity of Spodoptera frugiperda and Limited Its Population Growth
Authors: Yuan Xi , Wei Shengbao , Li Dunsong , Zhang Jiaen
Published: March 2023

Light is a crucial environmental factor implicated in the temporal regulation of important biological events of insects, and some insects are usually sexually active in dark periods. However, the effects of light during dark periods on the growth, development, and fecundity of Spodoptera frugiperda, an important agricultural pest, remain unknown. In this study, we evaluated the effects of lighting in dark periods on the biological parameters of S. frugiperda in laboratory conditions. Our results showed that lighting in dark periods significantly prolonged the pre-adult stage and reduced the pupal survival and emergence rate. Moreover, the results indicated that the adult stage is the photoperiod-sensitive stage of S. frugiperda, and the fecundity and longevity of adults significantly reduced under lighting in dark periods, and the number of eggs per female moth decreased by 99% compared with the control. The mean generation time (T) of S. frugiperda population was the longest, and the intrinsic rate of natural increase (r) and finite rate of increase (λ) were the smallest under lighting in dark periods, and the population growth of S. frugiperda was significantly limited. Our findings may provide valuable insights to develop effective integrated pest management strategies to control S. frugiperda.
Energy Budgeting and Carbon Footprints Estimation of Fodder Maize Varieties Sown under Different Nutrient Management Practices in Indo-Gangetic Plains of India
Authors: Kumar Dinesh , Singh Magan , Kumar Sanjeev , Meena Rajesh Kumar , Kumar Rakesh , Yadav Malu Ram , Kushwaha Manish , Makarana Govind , Bhattacharjee Subhradip , Kashyap Suryakanta , Biswal Bisworanjita , Rajesh  , Kumar Parveen
Published: March 2023

Inappropriate agricultural practices consume more input energy and emit higher greenhouse gases (GHGs) which cause global warming and climate change, thereby threatening environmental sustainability. To identify energy and carbon-efficient varieties and nutrient management practices, the present study was undertaken during the kharif season of 2018 and 2019 in a split-plot design with three varieties of fodder maize (African Tall, J-1006 and P-3396) and four nutrient management practices such as N0: Absolute control, N1: 100% recommended dose of fertilizers (RDF), N2: 75% RDF + plant growth promoting rhizobacteria (PGPR) + Panchagavya spray and N3: 50% RDF + 25% farmyard manure (FYM) + PGPR + Panchagavya spray). Results indicated that variety J-1006 and applying 75% RDF + PGPR + Panchagavya spray produced significantly higher dry fodder yield. Among the varieties, J-1006 recorded the highest total energy output (224,123 MJ ha−1), net energy (211,280 MJ ha−1), energy use efficiency (17.64), energy productivity (0.98 kg MJ−1), energy profitability (16.64), and lowest specific energy (1.03 MJ ha−1). Regarding nutrient management, 75% RDF + PGPR + Panchagavya spray fetched the highest total energy output (229,470 MJ ha−1) and net energy (215,482 MJ ha−1). However, energy use efficiency, energy productivity, and energy profitability were significantly higher with integrated nutrient management (N2 and N3) over 100% RDF. Concerning the carbon estimation, J-1006 resulted in a significantly higher carbon output (5479 kg CE ha−1), net carbon gain (5029 kg CE ha−1), carbon efficiency (12.46), carbon sustainability index (11.46), and significantly lower carbon footprint per unit yield (CFy) (131.3 kg CO2-e Mg−1). For nutrient management, the application of 75% RDF + PGPR + Panchagavya spray showed significantly higher carbon output (5609 kg CE ha−1) and net carbon gain (5112 kg CE ha−1). However, significantly higher carbon efficiency, carbon sustainability index, and lower CFy were reported with integrated nutrient management over 100% RDF. Overall, selecting the J-1006 variety and applying 75% RDF + PGPR + Panchagavya spray for fodder maize cultivation could be the most productive in terms of dry fodder production, energy, and carbon efficiency approach.
Optimal Parameters to Milk Murciano-Granadina Goats in Mid and Low-Line Milking Parlours
Authors: Bueso-Ródenas Joel , Romero Gema , Roca Amparo , Moya Francisco , Alejandro Manuel , Díaz José Ramón
Published: March 2023

Recent short-term studies on Murciano-Granadina goats have established that the optimal parameters to set up the milking machines are different according to the milk pipes height. Two groups of 52 fresh goats each were employed in 2 different experiments to confirm during an entire lactation period the best combinations of system vacuum pulsation rate and pulsator ratio in low-line and mid-line milking parlours. The experiment performed in the low-line milking parlour included one group milked with 40 KPa vacuum system level, 90 puls/min pulsation rate and 60/40 pulsation and a second group milked with 38 KPa vacuum system level, 90 puls/min pulsation rate and 60/40 pulsation ratio. The experiment carried out in mid-line included one group milked with 40 KPa vacuum system level, 90 puls/min pulsation rate and 60/40 pulsation ratio and a second group milked with 40 KPa vacuum system level, 120 puls/min pulsation rate and 60/40 pulsation ratio. Variables studied included milking efficiency, milk composition, cortisol, SCC and intramammary infections, teat-end oedema after milking and vacuum dynamics during milking. Considering the results of an entire lactation period, it was confirmed that when milking in mid-line, the combination of 40 KPa system vacuum, 90 cycles/min pulsation rate and 60/40 pulsator ratio showed optimal results of the above-mentioned variables. On the other hand, the use of 40 KPa in a low-line system increased the milk cortisol values (0.34 ± 0.1 vs. 0.44 ± 0.1 ng/mL) without any other advantage. Thus, the recommendation is to use a combination of 38 KPa system vacuum, 90 cycles/min pulsation rate and 60/40 pulsator ratio to enhance animal welfare.
Chinese Domestic Ducks Evolved from Mallard Duck (Anas platyrhynchos) and Spot-Billed Duck (A. zonorhyncha)
Authors: Zhang Yang , Bao Qiang , Cao Zhi , Bian Youqing , Zhang Yu , Cao Zhengfeng , Chen Guohong , Xu Qi
Published: March 2023

China has a rich genetic resource in its 34 domestic duck breeds. In order to detect the genetic diversity and explore the origin of these indigenous duck populations, the mitochondrial DNA (mtDNA) control region was sequenced and analyzed for 208 individual ducks, including 22 domestic breeds, wild Mallards ducks, Eastern spot-billed ducks, White Muscovy ducks, and Black Muscovy ducks. The haplotype diversity (Hd) was 0.653 and the average nucleotide diversity (Pi) was 0.005, indicating moderate genetic diversity. Sixty haplotypes were detected, and the maximum-likelihood (ML) phylogenetic tree and median-joining (MJ) network were generated from the sequence analyses. In this study, haplotypes from the Mallard duck (Anas platyrhynchos) were detected in most of the Chinese domestic duck breeds. In addition, the Eastern spot-billed duck (A. zonorhyncha) H8 haplotype was detected in two duck breeds. Only two haplotypes were found in Muscovy ducks, suggesting low genetic diversity within this population. The sequence and haplotype analyses revealed that both A. platyrhynchos and A. zonorhyncha contributed to the evolution of domestic ducks in China.
Mineral Content of Liver of Buffaloes (Bubalus bubalis) Reared in Different Ecosystems in the Eastern Amazon
Authors: Rodrigues Laurena Silva , da Silva Jamile Andréa Rodrigues , Lourenço-Júnior José de Brito , e Silva André Guimarães Maciel , de Almeida André Martinho , Mourato Miguel Pedro , de Castro Vinicius Costa Gomes , da Silva Welligton Conceição , Prates José António Mestre
Published: March 2023

This study aimed to evaluate the influence of different production ecosystems, three in native and cultivated pastures (extensive), at two seasons of the year (dry and rainy), and one in confinement (intensive) in the Eastern Amazon, on the mineral content of buffalo liver raised on these ecosystems. Twelve male buffalo (n = 12), aged between 24 and 36 months, slaughtered in commercial slaughterhouses, were used in each of the ecosystems considered: Marajó; Lower Amazon; Cultivated Pasture, and in confinement system, Pará, Brazil. Approximately 5 g of liver was collected, stored and frozen until lyophilization. Samples were analyzed for mineral content based on inductively coupled plasma optical emission spectrometry (ICPOES) readings. The relationship between extensive ecosystems and an intensive production system (p < 0.05) in the values of potassium (K), iron (Fe), copper (Cu), manganese (Mn) and barium (Ba) was evaluated. The different ecosystems studied influenced (p < 0.05) the mineral values found in the liver of buffaloes raised in the ecosystems, for sodium (Na), K, calcium (Ca), magnesium (Mg), sulfur (S), copper (Cu), iron (Fe), manganese (Mn) and barium (Ba). The period of the year interacted with the values of Na, K, S and Cu; however, an interaction of local vs. period of the yer was observed for the values of K, Mg, P, S and Cu. It can be concluded that the buffalo liver is an excellent source of minerals and can be included in the human diet and that the ecosystem the animals are raised influences its content.
Identifying Potential Super-Spreaders and Disease Transmission Hotspots Using White-Tailed Deer Scraping Networks
Authors: Hearst Scoty , Huang Miranda , Johnson Bryant , Rummells Elijah
Published: March 2023

White-tailed deer (Odocoileus virginianus, WTD) spread communicable diseases such the zoonotic coronavirus SARS-CoV-2, which is a major public health concern, and chronic wasting disease (CWD), a fatal, highly contagious prion disease occurring in cervids. Currently, it is not well understood how WTD are spreading these diseases. In this paper, we speculate that “super-spreaders” mediate disease transmission via direct social interactions and indirectly via body fluids exchanged at scrape sites. Super-spreaders are infected individuals that infect more contacts than other infectious individuals within a population. In this study, we used network analysis from scrape visitation data to identify potential super-spreaders among multiple communities of a rural WTD herd. We combined local network communities to form a large region-wide social network consisting of 96 male WTD. Analysis of WTD bachelor groups and random network modeling demonstrated that scraping networks depict real social networks, allowing detection of direct and indirect contacts, which could spread diseases. Using this regional network, we model three major types of potential super-spreaders of communicable disease: in-degree, out-degree, and betweenness potential super-spreaders. We found out-degree and betweenness potential super-spreaders to be critical for disease transmission across multiple communities. Analysis of age structure revealed that potential super-spreaders were mostly young males, less than 2.5 years of age. We also used social network analysis to measure the outbreak potential across the landscape using a new technique to locate disease transmission hotspots. To model indirect transmission risk, we developed the first scrape-to-scrape network model demonstrating connectivity of scrape sites. Comparing scrape betweenness scores allowed us to locate high-risk transmission crossroads between communities. We also monitored predator activity, hunting activity, and hunter harvests to better understand how predation influences social networks and potential disease transmission. We found that predator activity significantly influenced the age structure of scraping communities. We assessed disease-management strategies by social-network modeling using hunter harvests or removal of potential super-spreaders, which fragmented WTD social networks reducing the potential spread of disease. Overall, this study demonstrates a model capable of predicting potential super-spreaders of diseases, outlines methods to locate transmission hotspots and community crossroads, and provides new insight for disease management and outbreak prevention strategies.
Seroprevalence of and Risk Factors for Toxoplasma gondii Infection in Cats from Greece
Authors: Kokkinaki Kassiopi Christina G. , Saridomichelakis Manolis N. , Mylonakis Mathios E. , Leontides Leonidas , Xenoulis Panagiotis G.
Published: March 2023

Toxoplasmosis is one of the most important protozoan diseases with a global impact on the health of domestic cats and with zoonotic significance. The aims of this study were to determine the prevalence of seropositivity for Toxoplasma gondii in different populations of cats in Greece and to assess risk factors for seropositivity. A total of 457 cats were prospectively enrolled, and a commercially available indirect immunofluorescence antibody testing (IFAT) kit was used for the detection of anti-T. gondii immunoglobulin G (IgG) in serum. Overall, 95 (20.8%) of the 457 cats were seropositive for T. gondii. Based on multivariate analysis, factors associated with seropositivity included older age [Odds ratio (OR), 1.33; p < 0.001]; a history of cat-fight trauma (OR, 3.88; p = 0.004); and lack of vaccination against calicivirus, herpesvirus-1, panleukopenia, and rabies (OR, 10; p = 0.002). This study shows a high prevalence of seropositivity for T. gondii in cats in Greece. This implies that toxoplasmosis is still a major public health concern and that optimal strategies for the prevention of infection with T. gondii in cats should be established.
What to Do with the New Antibiotics?
Authors: Chaïbi Khalil , Jaureguy Françoise , Do Rego Hermann , Ruiz Pablo , Mory Céline , El Helali Najoua , Mrabet Sara , Mizrahi Assaf , Zahar Jean-Ralph , Pilmis Benoît
Published: March 2023

Multidrug-resistant Gram-negative bacteria-related infections have become a real public health problem and have exposed the risk of a therapeutic impasse. In recent years, many new antibiotics have been introduced to enrich the therapeutic armamentarium. Among these new molecules, some are mainly of interest for the treatment of the multidrug-resistant infections associated with Pseudomonas aeruginosa (ceftolozane/tazobactam and imipenem/relebactam); others are for carbapenem-resistant infections associated with Enterobacterales (ceftazidime/avibactam, meropenem/vaborbactam); and finally, there are others that are effective on the majority of multidrug-resistant Gram-negative bacilli (cefiderocol). Most international guidelines recommend these new antibiotics in the treatment of microbiologically documented infections. However, given the significant morbidity and mortality of these infections, particularly in the case of inadequate therapy, it is important to consider the place of these antibiotics in probabilistic treatment. Knowledge of the risk factors for multidrug-resistant Gram-negative bacilli (local ecology, prior colonization, failure of prior antibiotic therapy, and source of infection) seems necessary in order to optimize antibiotic prescriptions. In this review, we will assess these different antibiotics according to the epidemiological data.
Landscape and Climate Changes in Southeastern Amazonia from Quaternary Records of Upland Lakes
Authors: Guimarães José Tasso Felix , Sahoo Prafulla Kumar , e Souza-Filho Pedro Walfir Martins , da Silva Marcio Sousa , Rodrigues Tarcísio Magevski , da Silva Edilson Freitas , Reis Luiza Santos , de Figueiredo Mariana Maha Jana Costa , Lopes Karen da Silva , Moraes Aline Mamede , Leite Alessandro Sabá , da Silva Júnior Renato Oliveira , Salomão Gabriel Negreiros , Dall’Agnol Roberto
Published: March 2023

The upland lakes (ULs) in Carajás, southeastern Amazonia, have been extensively studied with respect to their high-resolution structural geology, geomorphology, stratigraphy, multielement and isotope geochemistry, palynology and limnology. These studies have generated large multiproxy datasets, which were integrated in this review to explain the formation and evolution of the ULs. These ULs evolved during the Pliocene–Pleistocene periods through several episodes of a subsidence of the lateritic crust (canga) promoted by fault reactivation. The resulting ULs were filled under wet/dry and warm/cool paleoclimatic conditions during the Pleistocene period. The multielement geochemical signature indicates that the detrital sediments of these ULs were predominantly derived from weathered canga and ferruginous soils, while the sedimentary organic matter came from autochthonous (siliceous sponge spicules, algae, macrophytes) and allochthonous (C3/C4 canga and forest plants and freshwater dissolved organic carbon) sources. Modern pollen rain suggests that even small ULs can record both the influence of canga vegetation and forest signals; thus, they can serve as reliable sites to provide a record of vegetation history. The integrated data from the sedimentary cores indicate that the active ULs have never dried up during the last 50 ka cal BP. However, subaerial exposure occurred in filled ULs, such as the Tarzan mountain range during the Last Glacial Maximum (LGM) and the Bocaína and S11 mountain ranges in the mid-Holocene period, due to the drier conditions. Considering the organic proxies, the expansion of C4 plants has been observed in the S11 and Tarzan ULs during dry events. Extensive precipitation of siderite in UL deposits during the LGM indicated drier paleoenvironmental conditions, interrupting the predominantly wet conditions. However, there is no evidence of widespread forest replacement by savanna in the Carajás plateau of southeastern Amazonia during the late Pleistocene and Holocene.
Compression of Bio-Signals Using Block-Based Haar Wavelet Transform and COVIDOA for IoMT Systems
Authors: Khafaga Doaa Sami , Aldakheel Eman Abdullah , Khalid Asmaa M. , Hamza Hanaa M. , Hosny Khaid M.
Published: March 2023

Background: Bio-signals are the essential data that smart healthcare systems require for diagnosing and treating common diseases. However, the amount of these signals that need to be processed and analyzed by healthcare systems is huge. Dealing with such a vast amount of data presents difficulties, such as the need for high storage and transmission capabilities. In addition, retaining the most useful clinical information in the input signal is essential while applying compression. Methods: This paper proposes an algorithm for the efficient compression of bio-signals for IoMT applications. This algorithm extracts the features of the input signal using block-based HWT and then selects the most important features for reconstruction using the novel COVIDOA. Results: We utilized two different public datasets for evaluation: MIT-BIH arrhythmia and EEG Motor Movement/Imagery, for ECG and EEG signals, respectively. The proposed algorithm’s average values for CR, PRD, NCC, and QS are 18.06, 0.2470, 0.9467, and 85.366 for ECG signals and 12.6668, 0.4014, 0.9187, and 32.4809 for EEG signals. Further, the proposed algorithm shows its efficiency over other existing techniques regarding processing time. Conclusions: Experiments show that the proposed method successfully achieved a high CR while maintaining an excellent level of signal reconstruction in addition to its reduced processing time compared with the existing techniques.
Automated Diagnosis of Diabetic Retinopathy Using Deep Learning: On the Search of Segmented Retinal Blood Vessel Images for Better Performance
Authors: Khan Mohammad B. , Ahmad Mohiuddin , Yaakob Shamshul B. , Shahrior Rahat , Rashid Mohd A. , Higa Hiroki
Published: March 2023

Diabetic retinopathy is one of the most significant retinal diseases that can lead to blindness. As a result, it is critical to receive a prompt diagnosis of the disease. Manual screening can result in misdiagnosis due to human error and limited human capability. In such cases, using a deep learning-based automated diagnosis of the disease could aid in early detection and treatment. In deep learning-based analysis, the original and segmented blood vessels are typically used for diagnosis. However, it is still unclear which approach is superior. In this study, a comparison of two deep learning approaches (Inception v3 and DenseNet-121) was performed on two different datasets of colored images and segmented images. The study’s findings revealed that the accuracy for original images on both Inception v3 and DenseNet-121 equaled 0.8 or higher, whereas the segmented retinal blood vessels under both approaches provided an accuracy of just greater than 0.6, demonstrating that the segmented vessels do not add much utility to the deep learning-based analysis. The study’s findings show that the original-colored images are more significant in diagnosing retinopathy than the extracted retinal blood vessels.
Recent Advance of Strontium Functionalized in Biomaterials for Bone Regeneration
Authors: Liu Xin , Huang Huagui , Zhang Jing , Sun Tianze , Zhang Wentao , Li Zhonghai
Published: March 2023

Bone defect disease causes damage to people’s lives and property, and how to effectively promote bone regeneration is still a big clinical challenge. Most of the current repair methods focus on filling the defects, which has a poor effect on bone regeneration. Therefore, how to effectively promote bone regeneration while repairing the defects at the same time has become a challenge for clinicians and researchers. Strontium (Sr) is a trace element required by the human body, which mainly exists in human bones. Due to its unique dual properties of promoting the proliferation and differentiation of osteoblasts and inhibiting osteoclast activity, it has attracted extensive research on bone defect repair in recent years. With the deep development of research, the mechanisms of Sr in the process of bone regeneration in the human body have been clarified, and the effects of Sr on osteoblasts, osteoclasts, mesenchymal stem cells (MSCs), and the inflammatory microenvironment in the process of bone regeneration have been widely recognized. Based on the development of technology such as bioengineering, it is possible that Sr can be better loaded onto biomaterials. Even though the clinical application of Sr is currently limited and relevant clinical research still needs to be developed, Sr-composited bone tissue engineering biomaterials have achieved satisfactory results in vitro and in vivo studies. The Sr compound together with biomaterials to promote bone regeneration will be a development direction in the future. This review will present a brief overview of the relevant mechanisms of Sr in the process of bone regeneration and the related latest studies of Sr combined with biomaterials. The aim of this paper is to highlight the potential prospects of Sr functionalized in biomaterials.