bluuebunny/crossref_metadata_2025 huggingface dataset:
Thermodynamic control of mismatch discrimination for extensive splicing regulation of PKM pre-mRNA
Authors: Bartys Natalia , Lisowiec-Wachnicka Jolanta , Pasternak Anna
Published: December 2024

In this article, we present an approach to maximizing the splicing regulatory properties of splice-switching oligonucleotide (SSO) designed to regulate alternative splicing of PKM pre-mRNA. The studied SSO interacts with the regulatory element in exon 10 of PKM pre-mRNA and contributes to a significant reduction of PKM2 level with a simultaneous increase of the PKM1 isoform. This SSO forms a duplex not only with the regulatory fragment of exon 10 but also with a similar RNA fragment of intron 9. The impact of this unspecific interaction on SSO regulatory properties, as well as the functional role of the intron 9 fragment, remains debatable. Herein, two types of modified nucleotides, unlocked nucleic acids (UNAs) and locked nucleic acids (LNAs), were used to study mismatch discrimination within duplexes involving modified SSOs. Our studies showed that LNAs increased mismatch discrimination, resulting in stronger regulatory properties of SSO. On the other hand, UNA reduced mismatch discrimination, decreasing the potentially therapeutic properties of SSO. The results indicate that specific interactions with exon 10 are more favorable for therapeutic applications, than simultaneous hybridization with intron 9 and exon 10. The results also suggest the lack of a regulatory role for the intron 9 target site in alternative splicing of PKM pre-mRNA.
Saúde mental relacionada ao trabalho na jurisprudência dos Tribunais Regionais do Trabalho do Estado de São Paulo
Authors: Beltramelli Neto Silvio , Hage Thalita
Published: December 2024

Objetivo: Trata-se de pesquisa que se propôs a compreender: (i) quais discussões processuais têm exigido dos TRTs da 2ª e da 15ª Regiões tratamento de temas ligados à saúde mental relacionada ao trabalho (SMRT); (ii) se os fundamentos decisórios, quando aludem ao assunto, o fazem tendo em perspectiva preceitos científicos oferecidos pela academia; e (iii) examinar se as decisões judiciais dos referidos Tribunais têm abordado a SMRT de uma forma central e decisiva ou perfunctória e não determinante para o resultado dos julgamentos.
Metodologia: Tratou-se de pesquisa empírica qualitativa do tipo estudo de casos descritivo exploratório, baseado em análise documental de acórdãos proferidos, entre os anos de 2020 e 2022, pelos TRTs da 2ª e da 15ª Regiões.
Resultados: Os resultados apontam para a necessidade de ampliação da compreensão por Magistradas e Magistrados do Trabalho oficiantes no Estado de São Paulo sobre a complexidade e a multifatorialidade do fenômeno da SMRT, bem como acerca das ferramentas de diagnóstico e eliminação dos diversos fatores e agentes de risco à saúde mental e ao bem-estar de quem trabalha.
Contribuições: A pesquisa relatada buscou provocar uma discussão sobre como a Justiça do Trabalho brasileira vem desempenhando a missão legal de proteção da SMRT, de forma a contribuir com a efetivação, pela via jurisprudencial, do direito humano ao meio ambiente de trabalho seguro e saudável, sem que seja omitida ou deficientemente considerada sua dimensão atinente à saúde mental e ao bem-estar de quem trabalha.
Digital auscultation in clear and present threat of novel respiratory infectious disease: a narrative review
Authors: Lee Heeeon , Kim Gun , Bae Jacob Sangwoon
Published: December 2024

The coronavirus disease 2019 pandemic has underscored the limitations of traditional diagnostic methods, particularly in ensuring the safety of healthcare workers and patients during infectious outbreaks. Smartphone-based digital stethoscopes enhanced with artificial intelligence (AI) have emerged as potential tools for addressing these challenges by enabling remote, efficient, and accessible auscultation. Despite advancements, most existing systems depend on additional hardware and external processing, increasing costs and complicating deployment. This review examines the feasibility and limitations of smartphone-based digital stethoscopes powered by AI, focusing on their ability to perform real-time analyses of audible and inaudible sound frequencies. We also explore the regulatory barriers, data storage challenges, and diagnostic accuracy issues that must be addressed to facilitate broader adoption. The implementation of these devices in veterinary medicine is discussed as a practical step toward refining their applications. With targeted improvements and careful consideration of existing limitations, smartphone-based AI stethoscopes could enhance diagnostic capabilities in human and animal healthcare settings.
Pierwsze polskie tłumaczenie Luzjad Camõesa
Authors: Brzozowski Jerzy
Published: December 2024

THE FIRST POLISH TRANSLATION OF CAMÕES’ LUSIADS
This year we celebrate the 500th anniversary of the birth of Luis de Camões, Portugal’s greatest poet. For a translation scholar, this is a special occasion to mention the first Polish translation of The Lusiads, published in 1790 by the unjustly forgotten, or rather: unjustly disregarded by posterity, Prof. Jacek Idzi Przybylski. This article aims to recall the achievements of the Kraków classical philologist, a translator of Voltaire’s most important works, but also of Homer’s Iliad, Virgil’s Aeneid and Georgics, Milton’s Paradise Lost, the works of Ovid, Horace, Hesiod… Przybylski’s work is uneven, but the mockery of his contemporaries, including the Enlightenment arbiter of elegance Dmochowski, was provoked by his predilection for creating not always fortunate neologisms – let us add, mainly in scientific works, to a much lesser extent literary ones. Dmochowski had personal reasons for his dislike of Przybylski, but this was not noticed by his contemporaries -– and surprisingly, once a malicious assessment was popularized, it was thoughtlessly repeated until the end of the 1970s. The analysis of the literary merits of Przybylski’s Luzyada, carried out by the author of this article, indicates, however, that the aforementioned negative judgments were extremely hasty. According to the author, this translation is worth restoring to the readership, for several reasons. First, none of the later translations impress us, and it is difficult to expect that someone in modern times will make another, more successful attempt. Second, when translating old poetry, we have a choice between the Scylla of archaic stylization and the Charybdis of modern translation. Przybylski’s 18th-century translation fortunately avoids both dangerous reefs: its antiquity is natural, so it already constitutes a certain added value at the starting point. What is more, however, the best fragments of this translation surprise us to this day with their freshness and originality.
„Dziękuję Ci że nie jest wszystko tylko białe albo czarne”
Authors: Kubaszczyk Joanna
Published: December 2024

“THANK YOU THAT EVERYTHING IS NOT JUST WHITE OR BLACK”. ON THE TRANSLATION OF RELIGIOUS VOCABULARY INTO GERMAN IN POETRY BY JAN TWARDOWSKIPoems by the priest Jan Twardowski are considered an outstanding example of religious lyric poetry. The aim of the article is to analyze his translated works in terms of the adequacy of the translation religious vocabulary and to answer the question of whether the translators managed to preserve not only the literal meaning of the works but also the nuanced meanings inherent in the original, and to indicate the difficulties that should be noted in this type of translation. The focus is on terminological issues, ambiguity, intertextual references, and metaphors. Conclusions of a general nature concern cultural competence in relation to the so-called high culture.
Effects of a School-Based Health Education for Cardiovascular Disease Prevention Among High School Girls
Authors: Kang Minah , Choo Jina
Published: December 2024

Purpose: We aimed to evaluate effects of a school-based health education for cardiovascular disease (CVD) prevention among high school girls. Methods: Non-randomized cluster trial was conducted by recruiting two female high schools located in Seoul and allocating one school as a cluster to an experimental group and the other school as the other cluster to a control group. Participants were 169 first-year female high school students in two clusters. Of the participants, 84 were recruited in the experimental group and 85 in the control group. An intervention was an eight-week "School-based Health Education for CVD prevention". The experimental group received the intervention, while the control group received a CVD prevention handout. Measures were knowledge, self-efficacy, and health behaviors for CVD prevention. The pre-test and post-test were conducted. Results: The experimental group participating in "School-Based Health Education for CVD Prevention" had significantly higher changes in knowledge, self-efficacy scores to prevent CVD, and health behaviors than the control group over eight weeks. Conclusions: The "School-based Health Education for CVD Prevention" program may improve high school students' knowledge and self-efficacy as determinants of health behaviors as well as health behaviors to prevent cardiovascular disease.
Malnutrition Risk in Community-Dwelling Older Adults with Dual Sensory Declines: Focusing on Social Determinants of Health
Authors: Jeong Ha Na
Published: December 2024

Purpose: As the number of older adults with dual sensory declines is increasing, they face a higher risk of malnutrition compared to those without these declines. Although social determinants of health can influence malnutrition, there has been limited research on this population. This study aimed to explore the association between malnutrition risk and social determinants of health among older adults with dual sensory declines. Methods: The study is a cross-sectional analysis using data from the 2020 National Survey of Older Koreans. Binomial logistic regression analysis was conducted to examine the association between malnutrition risk and social determinants of health. These determinants include structural determinants, social capital, and intermediary determinants among older adults with dual sensory declines. Results: 1,771 with dual sensory declines were included in the analysis. Among the structural determinants, women (odds ratio [OR]=1.75, 95% confidential interval [CI] 1.19~2.57) and national basic livelihood security system recipients (OR=1.87, 95% CI 1.13~3.07) were significantly associated with malnutrition risk. In social capital, social non-participation (OR=1.33, 95% CI 1.03~1.73) and social network size (OR=0.95, 95% CI 0.92~0.98), Among intermediary determinants, living dissatisfaction (OR=1.61, 95% CI 1.16~2.23), environmental satisfaction (OR=0.95, 95% CI 0.92~0.99), household debt (OR=1.59, 95% CI 1.02~2.49) and comorbidity (OR=3.85, 95% CI 2.98~4.97) were significantly related to malnutrition risk. Conclusion: These findings highlight the critical need to address key social determinants of health to enhance nutritional outcomes for older adults with dual sensory declines.
Factors Influencing Participation in Hypertension Management Education Among Diagnosed Hypertensive Patients in Busan: Utilizing the 2021 Community Health Survey
Authors: Jun Hye Jung , Kim Kyoung Mi
Published: December 2024

Purpose: This study investigated the completion rate of hypertension management education and its influencing factors among adults in the Busan region, utilizing data from the 2021 Community Health Survey.Methods: The study included 3,660 adults aged 19 years or older who had been diagnosed with hypertension. Data were analyzed using SAS 9.4, focusing on demographic, socioeconomic, and health status characteristics.Results: The results indicated that 22.1% of participants had completed hypertension management education. Key influencing factors varied by region: in the Western region, age, income, education level, marital status, and life satisfaction were significant factors associated with participation in hypertension management education. In the Southern region, income and education level were identified as relevant factors. Additionally, in the Central and Eastern regions, education level was a significant determinant.Conclusion: Therefore, tailored hypertension management education programs that consider age, income, marital status, and life satisfaction are essential for residents in the Western region of Busan. Moreover, it is critical to enhance access to hypertension management education for low-income populations in the Southern region. Educational programs should also be designed to align with the educational levels of Busan residents to ensure effective hypertension management education.
Downstream Information Sharing in Agricultural Supply Chains with Investment Spillovers
Authors: Fu Zunwei , Sun Hongchun , Xu Chenglong , Yue Mingshi
Published: December 2024

This paper investigates a product distributor’s incentive to share private consumer preference information with a farming cooperative who possesses the capability for quality improvement. Although conventional view holds that in the presence of the investment spillover effect, downstream information sharing surely occurs when the upstream investment cost is low enough, our results show that, due to the decreasing marginal effect of quality investment, the product distributor voluntarily commits to sharing information only when the quality investment cost is in a medium range. And this ex ante sharing behavior can be induced through a precontracted side payment when the quality cost slightly deviates from the range in which voluntary sharing occurs. Given the challenge of predicting consumer preference for perennial crops, we examine the product distributor’s incentives for ordering and ex post sharing under upfront quality improvement, finding that the distributor can partially disclose the acquired information even facing a potential mismatch between supply and demand. An equilibrium ordering scheme is proposed whereby the distributor prearranges transportation capacity. Interestingly, under delayed information acquisition, partially sharing information is more effective in motivating the farming cooperative to invest more at the outset than not sharing at all.

Conflict of Interest Statement: The authors declared that they have no conflicts of interest to this work.

Funding: This work was supported by Natural Science Foundation of Shandong Province [ZR2021MA079, ZR2021MA088]; National Natural Science Foundation of China [11271175].
Online Algorithms for Matching Platforms with Multichannel Traffic
Authors: Manshadi Vahideh , Rodilitz Scott , Saban Daniela , Suresh Akshaya
Published: December 2024

Two-sided platforms rely on their recommendation algorithms to help visitors successfully find a match. However, on platforms such as VolunteerMatch, which has facilitated millions of connections between volunteers and nonprofits, a sizable fraction of website traffic arrives directly to a nonprofit’s volunteering page via an external link, thus bypassing the platform’s recommendation algorithm. We study how such platforms should account for this external traffic in the design of their recommendation algorithms, given the goal of maximizing successful matches. We model the platform’s problem as a special case of online matching, where (using VolunteerMatch terminology) volunteers arrive sequentially and probabilistically match with one opportunity, each of which has a finite need for volunteers. In our framework, external traffic is interested only in their targeted opportunity; by contrast, internal traffic may be interested in many opportunities, and the platform’s online algorithm selects which opportunity to recommend. In evaluating the performance of different algorithms, we refine the notion of competitive ratio by parameterizing it based on the amount of external traffic. After demonstrating the shortcomings of a commonly used algorithm that is optimal in the absence of external traffic, we propose a new algorithm, adaptive capacity (AC), which accounts for matches differently based on whether they originate from internal or external traffic. We provide a lower bound on AC’s competitive ratio that is increasing in the amount of external traffic and that is close to (and, in some regimes, exactly matches) the parameterized upper bound we establish on the competitive ratio of any online algorithm. We complement our theoretical results with a numerical study motivated by VolunteerMatch data where we demonstrate the strong performance of AC relative to current practice and further our understanding of the difference between AC and other commonly used algorithms.

This paper was accepted by Omar Besbes, revenue management and market analytics.

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2022.00910 .
Is Information Risk Priced? New Evidence from Outer Space
Authors: Hao Xianfeng , Wang Shujing , Wang Yudong , Wu Liangyu
Published: December 2024

Satellite images of the parking lots of U.S. retail firms provide information about the firms’ future earnings, and the limited access to these images produces information asymmetry between sophisticated and unsophisticated investors. We construct a cloud-based information risk (CIR) measure to capture this satellite information risk and investigate its asset pricing performance. We find that CIR positively predicts future stock returns of retail firms in the cross-section and that the predictability cannot be explained by weather reasons. We provide evidence that CIR indeed captures the information asymmetry among investors. The profitability of short selling is more pronounced on clear days. The return predictability of CIR is more pronounced in preannouncement periods. During cloudy days, parking lot traffic data from satellite images are harder to obtain, and the retail store sales estimated using parking lot data are noisier. We further show that high CIR is associated with low liquidity and that the decrease in liquidity purchases is greater than the decrease in liquidity sales. Our empirical analyses suggest that information asymmetry is priced and that CIR affects equity premiums through the liquidity channel, which are consistent with the theoretical predictions from a noisy rational expectations equilibrium model under imperfect competition.

This paper was accepted by Kay Giesecke, finance.

Funding: S. Wang acknowledges financial support from the National Natural Science Foundation of China [Grants 72373110 and 71902140] and Fundamental Research Funds for the Central Universities in China. Y. Wang acknowledges financial support from the National Natural Science Foundation of China [Grants 72342003 and 72071114].

Supplemental Material: The online appendix and data files are available at https://doi.org/10.1287/mnsc.2023.00713 .
The Fragility of Optimized Bandit Algorithms
Authors: Fan Lin , Glynn Peter W.
Published: December 2024

What Does the Distribution of Regret Look Like for Bandit Algorithms?

In multiarmed bandit theory, the expected regret has long been the predominant performance measure studied in the literature. For the first time, in “The fragility of optimized bandit algorithms,” Fan and Glynn study the tail of the regret distribution. For a given bandit model, it is natural to optimize to achieve the minimum possible expected regret growth rate. However, the authors show that optimizing for expected regret alone can result in severe fragility. Optimized expected regret rates come with the side effect of extremely heavy regret tails (like those of a Cauchy distribution) and thus, significant chance of catastrophically large regret. Moreover, optimized algorithms essentially operate on a knife’s edge such that the slightest degree of model misspecification in algorithm design can result in a much larger expected regret rate. Among other insights, the authors characterize sharp trade-offs between the expected regret rate and the heaviness of the regret tail. They also show how to robustify an algorithm and lighten the regret tail through increased exploration.
GEOLOGI DAN KARAKTERISTIK MINERAL PIROPILIT DAERAH SUMBERMANJING WETAN, MALANG
Authors: Heru Sapto , Prasetia Gilang Eko
Published: December 2024

Penelitian dilakukan di Daerah Ringinkembar dan Sekitarnya, Sumbermanjing Wetan, Malang. Berdasarkan Peta Geologi Regional Lembar Turen, batuan penyusun daerah penelitian masuk dalam Formasi Mandalika dengan umur Oligosen Akhir hingga Miosen Awal. Formasi Mandalika terusun oleh satuan batuan vulkanik antara lain andesit, dasit dan tuff, dan batuan tersebut telah banyak mengalami ubahan (alterasi). Salah satu hasil mineral ubahannya adalah mineral pirolopilit, yang dominan terdapat pada zona alterasi argilik lanjut. Mineral piropilit yang ada di daerah Sumbermanjing Wetan, Malang sudah banyak yang ditambang, salah satunya digunakan untuk bahan baku campuran keramik, atau bahan baku industri lainnya. Penelitian ini bertujuan untuk mengetahui kondisi geologi dan kararteristik mineral piropilit di daerah penelitian berdasarkan sifat fisik dan kandungan kimia mineral piropilit. Metode yang digunakan adalah pemetaan geologi permukaan dan analisis sampel batuan X-Ray Difracttion (XRD) di laboratorium. Berdasarkan pemetaan geologi permukaan, geomorfologi di daerah penelitian tersusun satuan perbukitan struktural bergelombang sedang hingga kuat struktural yang berhubungan dengan kekar dan patahan. Litologi penyusunnya dari tua ke muda satuan andesit, satuan tuff, satuan batupasir, dan satuan batugamping. Struktur geologi berupa kekar yang memiliki arah N 10o E. Zona alterasi daerah penelitian terdapat  zona alterasi propilitik dan zona argilik lanjut. Berdasarkan analisis sampel batuan, mineral piropilit dilihat dari kandungan alumina dan kuarsa terdapat 4 tipe mineral piropilit di daerah penelitian. Tipe A piropilit alumina tinggi, Tipe B piropilit silika rendah, Tipe C piropilit silika tinggi dengan diaspore, dan Tipe D piropilit dengan alkali rendah
ANALISIS POLAR DIAGRAM DAN TENSOR FASE UNTUK PEMODELAN 2D MODE TE DAN TM DATA MAGNETOTELLURIK SAN PABLO BAY, CALIFORNIA, USA
Authors: Irawati Selvi Misnia , Sitorus Dorlensa , Paembonan Andri Yadi
Published: December 2024

Daerah San Pablo Bay California mempunyai patahan utama yaitu patahan Rodgers Creek yang diperkirakan memiliki keberlanjutan pada patahan Hayward di bawah permukaan San Pablo Bay yang dapat mengakibatkan bencana alam seperti gempa bumi. Penelitian ini bertujuan untuk memahami dimensionalitas dan arah geoelectrical strike melalui analisis diagram polar dan tensor fase, serta pemodelan 2D TE mode dan TM. Penelitian ini juga bertujuan dalam mengidentifikasi struktur bawah permukaan di wilayah San Pablo Bay, California, USA, dengan menggunakan metode magnetotellurik (MT). Terdapat 14 titik pengukuran data MT yang digunakan. Hasil pengolahan data menunjukkan bahwa di daerah penelitian terdapat dimensionalitas 2D dengan arah geoelectrical strike dari barat daya ke timur laut sebesar N50°E. Berdasarkan penampang resistivitas 2D pada TE mode dan TM mode, struktur utama Rodgers Creek teridentifikasi di titik SP12. Struktur ini mencapai kedalaman 1250 m pada TE mode serta 1700 m pada TM mode di bawah permukaan Teluk San Pablo Bay yang terdiri dari batuan sedimen kuarter. Selain itu, juga terdapat struktur minor pada titik SP01 - SP02, SP06 - SP07, dan SP09, dengan kedalaman antara 100 - 500 m.
Pemanfaatan Teknologi Aquaponic pada Pondok Pesantren sebagai Upaya Pemberdayaan untuk Kemandirian Pondok Pesantren di Turirejo, Lawang, Kab. Malang, Jawa Timur
Authors: Zaini Ahmad , Muhtadin Muhtadin , Pramunanto Eko , Boedinoegroho Hanny , Setiawan Rachmad , Kurniawan Arief , Yuniarno Eko Mulyanto
Published: December 2024

Pondok pesantren merupakan lembaga pendidikan nirlaba yang umumnya berbiaya rendah atau bahkan gratis. Operasionalnya bergantung pada donasi masyarakat dan unit usaha yang dimiliki. Namun, kemampuan setiap pesantren berbeda-beda; hanya pesantren besar dengan sejarah panjang yang mampu mandiri dalam memenuhi kebutuhan operasionalnya. Sebaliknya, banyak pesantren kecil menghadapi tantangan finansial untuk tetap menjaga kualitas layanan, karena donasi yang diterima sering kali tidak mencukupi. Dalam program pengabdian masyarakat ini, dilakukan pelatihan pemanfaatan teknologi aquaponic di pesantren sebagai solusi inovatif. Teknologi ini dipilih karena tidak memerlukan lahan yang luas serta mudah dikelola, sehingga cocok untuk memenuhi kebutuhan konsumsi sehari-hari santri, seperti sayuran dan ikan air tawar. Selain itu, kelebihan hasil produksi dapat dijual untuk menambah pendapatan pesantren. Pelatihan ini memberikan dampak positif, terutama dalam meningkatkan keterampilan santri mengelola aquaponic, yang dapat menjadi bekal wirausaha di masa depan. Lebih jauh, hasil panen dari dua kali produksi memberikan kontribusi nyata bagi operasional pesantren, dengan total pendapatan sebesar Rp11.400.000 dalam bentuk in kind dan in cash. Program ini menunjukkan potensi kemandirian finansial bagi pesantren secara berkelanjutan.
Pengembangan Bisnis dan Pendampingan Manajemen Keuangan dalam Pengelolaan Unit Usaha di SLB Putra Manunggal, Kebumen, Jawa Tengah
Authors: Partiwi Sri Gunani , Pratiwi Atikah Aghdhi , Sholihah Mar'atus , Basuki Satrio Samudro Aji , Wessiani Naning Aranti , Suwignjo Patdono , Wibowo Chandra Aryo , Wiscahyo Gelar , Akmal Izzane Muhammad , Firdaus Rachmad Rizky , Santi Regita Ahda , Sanjaya Rhasyah Ramadhani
Published: December 2024

Kegiatan pengabdian masyarakat yang dilakukan di Yayasan Pendidikan Luar Biasa (YPLB) Sekolah Luar Biasa (SLB) Putra Manunggal bertujuan untuk meningkatkan pengelolaan unit usaha yang dikelola oleh lembaga ini. SLB Putra Manunggal menyediakan pendidikan untuk anak-anak berkebutuhan khusus dan telah menjalankan beberapa unit usaha, yaitu Warung/Toko Kelontong, Ecoprint, dan Cuci Mobil. Pengelolaan ketiga unit usaha tersebut masih belum optimal, sehingga memerlukan pendampingan dan pembinaan dari pihak eksternal. Kegiatan ini mencakup identifikasi kondisi eksisting, perancangan strategi bisnis, serta pelatihan dan pendampingan dalam pengelolaan keuangan, termasuk akuntansi dasar dan penyusunan laporan keuangan seperti laporan laba rugi, arus kas, dan neraca. Dengan menggunakan metode analisis SWOT, strategi yang relevan dikembangkan untuk memanfaatkan kekuatan dan peluang serta mengatasi kelemahan dan ancaman. Kegiatan ini diharapkan dapat menciptakan efek berganda (multiplier effect) bagi peserta didik dan masyarakat sekitar, seperti peningkatan kesejahteraan dan penciptaan lapangan kerja, serta mendukung kemandirian lembaga.
Pembuatan Pakan Ternak Fermentasi di Kabupaten Madiun
Authors: Rosyidah Afifah , Cholidah Tsana , Rosanti Yuniar Frida , Febriyanti Tria , Amalia Inka , Maylina Wenny , Izzananto Muhammad Daffa
Published: December 2024

Hewan ruminansia (sapi, kambing, domba) menjadi penghasil bahan pangan bernilai gizi tinggi dan memasok dua dari tiga nutrien utama yang diperlukan manusia, yakni protein dan lipid. Populasi ruminansia di Kecamatan Kare Kabupaten Madiun cukup tinggi, dan konsumsi dagingnya juga terus meningkat. Meski demikian, kondisi saat ini menunjukkan ketersediaan pakan berkualitas masih menjadi persoalan besar, terutama akibat faktor musim, khususnya musim kemarau. Dampak kekurangan pakan sangat menentukan terhadap kesehatan dan produksi, juga terhadap fertilitas dan kekebalan hewan. Adanya berbagai dampak negatif kekurangan pakan atau nutrisi tersebut, sangat diperlukan adanya solusi terbaik. Pengabdi menyelesaikan masalah ketersediaan pakan ini melalui pendampingan pengolahan pakan ternak fermentasi yang bahan bakunya sangat melimpah pada musim panen. Penambahan “Effective Microorganism” yaitu suatu larutan kultur (biakan) dari mikroorganisme yang hidup secara alami di tanah yang subur; sangat bermanfaat untuk peningkatan produksi pakan fermentasi ini. Hasil yang diperoleh menunjukkan bahwa pakan fermentasi yang dibuat sangat disukai oleh ternak dan mampu meningkatkan bobotnya. Pada usia yang sama, yaitu 3 bulan; berat ternak sebelum diberikan pakan fermentasi adalah 10 kg; sedangkan untuk ternak yang diberikan pakan fermentasi mengalami peningkatan bobot ternak sebesar 24,5 kg. Setiap disajikan pakan fermentasi, ternak menyantap dengan sangat lahap hingga habis.
Warning signs
Authors: Jucaite Edita
Published: December 2024

Edita Jucaite shares her journey through leukaemia.
ENTRE VIOLÊNCIAS E RESISTÊNCIAS: ESCREVIVÊNCIAS DE GÊNERO COM JOVENS PESQUISADORES
Authors: Soares Mayara Ruth Nishiyama , Miranda Luciana Lobo , Oliveira Marta Clarice Nascimento , Sousa Alanna Maria da Silva
Published: December 2024

Este artigo discute uma experiência de pesquisa sobre gênero e escola realizada com estudantes de uma escola pública periférica em Fortaleza/CE. Trata-se de uma Pesquisa-Inter(in)venção, aliada ao PesquisarCOM, tendo por forma de registro a Escrevivência. Se dá com base na experiência de um grupo de jovens pesquisadoras/es formado por estudantes secundaristas moradores da periferia em questão e universitárias. A partir das discussões, nos resultados a disputa em torno da ideologia de gênero apareceu transversal à experiência da pesquisa, habitando o cotidiano da escola produzindo práticas reguladoras que objetivam identidades coerentes com uma matriz de normas compulsoriamente heterossexuais. Em contraponto, neste mesmo território escolar, insurgem potências de existir frente às forças mortificantes já localizadas. Assim, conclui-se que o movimento antigênero produz um cenário violento a corpos dissidentes da norma cisheteropatriarcal, e, em meio a isso, insurgem, também, processos de resistências no cotidiano escolar.
Factores de riesgo y de protección del acoso escolar: el estudiante vulnerable en la República Dominicana
Authors: Córdoba Ana I. , Suero-Maloney Carlos , Tomás José M. , Esnaola Igor , Sancho Patricia , Jiménez-Hernández David
Published: December 2024

INTRODUCCIÓN. El acoso escolar es un problema que está muy presente en los centros educativos de todo el mundo con efectos devastadores para el alumnado. Por ello, el objetivo de este trabajo es conocer qué características sociodemográficas y psicológicas en el alumnado dominicano vulnerable funcionan como factores de riesgo y de protección frente al acoso escolar. MÉTODO. Se contó con una muestra de 531 estudiantes de secundaria de ambos sexos, con edades comprendidas entre los 11 y los 21 años, de República Dominicana, en la que se aplicaron seis cuestionarios. Concretamente fueron: el Autotest Cisneros de Acoso Escolar, la Escala de Agresividad Física y Verbal, el Cuestionario de Conducta Prosocial, la Escala de Inestabilidad Emocional, el Inventario de Ideación Suicida Positiva y Negativa y la Escala de Autoestima Global. Se realizaron análisis de medias MANOVA y ANOVA de continuación para estudiar la relación entre las variables de estudio. RESULTADOS. Los resultados mostraron que, entre las variables sociodemográficas, solo el primer grado de escolarización y el sexo masculino se vinculaban con el acoso, mientras que las variables psicológicas mostraron relaciones significativas y positivas con la agresión física y verbal, la ideación suicida negativa y la inestabilidad emocional; y negativas con la conducta prosocial, ideación suicida positiva y la autoestima. DISCUSIÓN. Estos resultados arrojan información relevante para prevenir y luchar contra el acoso escolar, partiendo del control de los factores que pueden ser de riesgo, como la agresión física y verbal o la inestabilidad emocional, y promoviendo los que pueden resultar protectores, como la conducta prosocial o la autoestima.
Cyberbullying in school environments: analyzing sociodemographic factors in Spanish students in the context of physical education
Authors: Galán-Arroyo Carmen , Polo-Campos Irene , Gómez-Paniagua Santiago , Rojo-Ramos Jorge
Published: December 2024

INTRODUCTION. Cyberbullying is a growing problem of great social concern. Today’s students face a major cyber threat, despite being more connected than ever before. This insidious behavior can have serious consequences for the mental health and academic performance of those affected. Knowing that Physical Education has a direct impact on these behaviors, the aim of this study is to analyze cyberbullying in the physical education classroom based on nine sociodemographic variables and 22 questions from the European Cyberbullying Intervention Project Questionnaire in a sample of 1232 Spanish students (aged 8 to 18 years). METHODS. A non-probabilistic convenience-based method was used to determine the sample size. To validate the assumption of normality in the statistical analysis, the Kolmogorov-Smirnov test was used. Non-parametric tests were used when this assumption was not met. The same variables were examined as in the differences according to the questionnaire items, in addition to five nominal sociodemographic questions differentiated according to the two dimensions of the questionnaire. Significant differences were observed between groups. The correlation between the dimension scores and the four continuous demographic questions was then examined using Spearman’s rho test. Finally, Cronbach’s alpha was used to assess the internal consistency. RESULTS. Although there are determinant variables of cyberbullying, sex did not seem to be one of them, although other studies have shown a wide range of results, establishing that context determines this behavior. Age and school cycle have more homogeneous evidence in this aspect, both in victimization and in the aggressor part. Access to smartphones and the Internet play a determining role. CONCLUSIONS. This study found that several factors influence cyberbullying. It would be interesting if prevention and educacommunicationprograms with respect to new information technologies were approved in administrations and school institutions, as well as detailing how harmful this type of abuse and others can be.
La relación entre las concepciones docentes y sus prácticas de evaluación en matemáticas
Authors: Oviedo Mandujano Angélica Fabiana , Caso Niebla Joaquín , González Barbera Coral
Published: December 2024

INTRODUCCIÓN. Ante la supuesta interrelación entre concepciones y prácticas docentes, y derivado de los problemas de bajo logro registrados en las pruebas de aprendizaje en primaria en el área de matemáticas, se plantea como objetivo conocer la asociación existente entre estos dos constructos, centrando el análisis en la evaluación en el aula. MÉTODO. Se desarrolló una investigación con diseño transversal, en la que participaron 4.674 docentes de primaria del estado de Baja California, México. La recolección de datos se realizó mediante la aplicación de un cuestionario de autoinforme compuesto por dos escalas tipo Likert, el cual se diseñó y validó en el marco de este estudio. RESULTADOS. A partir del cálculo de los coeficientes de correlación de Pearson y Spearman, se observó una asociación positiva entre las concepciones docentes y 22 de las 24 variables de prácticas de evaluación abordadas. Si bien los coeficientes de correlación no registraron valores altos, fue posible observar relaciones lógicas desde una perspectiva teórica en la mayoría de las variables. Sin embargo, en el caso de las estrategias de evaluación formativa, se identificaron relaciones poco congruentes con las concepciones docentes. Por su parte, las técnicas e instrumentos de evaluación no mostraron asociación. DISCUSIÓN. Lo anterior permite aceptar de manera parcial la hipótesis de investigación que plantea la relación entre las concepciones y prácticas de evaluación. Los resultados evidencian la importancia de fortalecer las concepciones docentes hacia tendencias pedagógicas que coloquen al estudiante en el centro del proceso educativo, así como reconocer la complejidad de la evaluación en el aula. Lo anterior exige la participación de distintos actores en el diseño e implementación de estrategias más integrales y efectivas que tengan como finalidad el aprendizaje del estudiantado.
Assessment of Behavioral and Palynological Attributes of Apis mellifera L. Foragers in a Mustard Ecosystem
Authors: Nath Riju , Saha Samrat , Laskar Nripendra
Published: December 2024

An investigation was carried out to assess different foraging activities of Apis mellifera L. in the mustard ecosystem by placing six strong A. mellifera colonies along the borders of mustard fields in the Terai agroecological region of West Bengal during 2019 and 2020. During this period, foragers of A. mellifera had a foraging duration of 9.41 ± 0.33 hours/day. Their activity was higher during mid-day than in the early morning and late evening hours. Temperature and bright sunshine hours strongly correlate with foraging duration and intensity. On the other hand, relative humidity and rainfall were negatively correlated with bee foraging. Foragers were found to spend maximum time on each flower at 11:00 – 13:00 hours, and their abundance was also high during this time interval. At initial hours of observation, i.e., at 07:00 – 09:00, foraging was minimal. The palynological assessment suggested that the foragers carry about 568,640 ± 15426.52 pollen on their bodies during peak foraging time. Apart from the pollen of Brassica sp., some other pollen types belonging to Ageratum conyzoides, Amaranthus/Chenopodium sp., Cajanus cajan, Leucas aspera, Spilanthes sp., and species of Polygonaceae and Solanaceae were also recovered from pollen load. However, these non-Brassica pollen frequency was very low in the pollen spectrum. This study provides information to assist local beekeepers in effectively managing their colonies by correlating foraging activity with weather parameters, and it will also advise mustard growers on establishing a prudent pesticide application schedule that will protect foraging bees from pesticide exposure.
Expression of Glycoprotein 2 and Its Glycosylation in Human Cowper’s Gland
Authors: Fukiage Yusuke , Low Shulin , Muramoto Akifumi , Ariga Yuzuru , Hoshino Hitomi , Nakada Tsutomu , Akama Tomoya O. , Kobayashi Motohiro
Published: December 2024

Glycoprotein 2 (GP2), initially identified as a primary membrane protein of zymogen granules in pancreatic acinar cells, is a marker of intestinal microfold cells (M cells) and involved in bacterial transcytosis in M cells. Recent studies have reported GP2 expression in the pancreas and intestine among various other organs. We aimed to elucidate the expression of GP2 and its glycosylation modifications in human Cowper’s glands. We generated an anti-human GP2 monoclonal antibody suitable for formalin-fixed, paraffin-embedded tissue sections. This antibody, designated GP2-71, successfully stained both the plasma membrane and cytoplasm of normal pancreatic acinar cells. Subsequently, we performed GP2-71 immunostaining on normal human Cowper’s gland tissues. Our findings revealed that the luminal cell membrane and contents of the Cowper’s glands reacted strongly with GP2-71. Moreover, the regions stained with GP2-71 were partially immunostained with the anti-sialyl Lewis x (sLex) monoclonal antibody HECA-452. Furthermore, western blot analysis of protein A-purified GP2-immunoglobulin G fusion proteins demonstrated that GP2 was decorated with HECA-452-positive glycans. Collectively, these findings indicate that GP2 is expressed in human Cowper’s glands and is potentially decorated with sLex-related glycans.
Addressing social equity in coastal climate adaptation planning: A case study of Norfolk, Virginia
Authors: Michel Valerie , Eghdami Sadegh , Shafiee-Jood Majid , Louis Garrick
Published: December 2024

The consequences of climate change, such as flooding, storms, heat waves, and other climate disasters, have had severe economic and health impacts, with vulnerable communities bearing a disproportionate burden. In Norfolk, Virginia, historical injustices such as redlining contribute to these disparities. This highlights the need to integrate social equity and community engagement into efforts to achieve environmental justice in climate risk management. Although relevant indices and diversity, equity, and inclusion officers have popularized social equity, a shared definition remains elusive. Localized solutions for coastal climate resilience allow governments to make decisions for their communities. However, they also risk contributing to differential outcomes, which may neglect some populations altogether, or limit the effectiveness of resource allocation because of missed opportunities for regional cooperation. This research used Norfolk, Virginia as a case study, conducting stakeholder interviews with representatives from various government levels, non-governmental organizations, and academic institutions to characterize social equity in coastal adaptation planning. The differences in stakeholder feedback and the tools they use for planning and program implementation may be instructive to other coastal communities seeking to integrate social equity in their climate risk management planning.
Automated craniofacial biometry with 3D T2w fetal MRI
Authors: Matthew Jacqueline , Uus Alena , Egloff Collado Alexia , Luis Aysha , Arulkumaran Sophie , Fukami-Gartner Abi , Kyriakopoulou Vanessa , Cromb Daniel , Wright Robert , Colford Kathleen , Deprez Maria , Hutter Jana , O’Muircheartaigh Jonathan , Malamateniou Christina , Razavi Reza , Story Lisa , Hajnal Joseph V. , Rutherford Mary A.
Published: December 2024

Objectives

Evaluating craniofacial phenotype-genotype correlations prenatally is increasingly important; however, it is subjective and challenging with 3D ultrasound. We developed an automated label propagation pipeline using 3D motion- corrected, slice-to-volume reconstructed (SVR) fetal MRI for craniofacial measurements.

Methods

A literature review and expert consensus identified 31 craniofacial biometrics for fetal MRI. An MRI atlas with defined anatomical landmarks served as a template for subject registration, auto-labelling, and biometric calculation. We assessed 108 healthy controls and 24 fetuses with Down syndrome (T21) in the third trimester (29–36 weeks gestational age, GA) to identify meaningful biometrics in T21. Reliability and reproducibility were evaluated in 10 random datasets by four observers.

Results

Automated labels were produced for all 132 subjects with a 0.3% placement error rate. Seven measurements, including anterior base of skull length and maxillary length, showed significant differences with large effect sizes between T21 and control groups (ANOVA, p<0.001). Manual measurements took 25–35 minutes per case, while automated extraction took approximately 5 minutes. Bland-Altman plots showed agreement within manual observer ranges except for mandibular width, which had higher variability. Extended GA growth charts (19–39 weeks), based on 280 control fetuses, were produced for future research.

Conclusion

This is the first automated atlas-based protocol using 3D SVR MRI for fetal craniofacial biometrics, accurately revealing morphological craniofacial differences in a T21 cohort. Future work should focus on improving measurement reliability, larger clinical cohorts, and technical advancements, to enhance prenatal care and phenotypic characterisation.
The prevalence and determinants of health anxiety during the covid-19 pandemic: A systematic review and meta-analysis
Authors: Plackett Ruth , Ferris Ella
Published: December 2024

The coronavirus disease 2019 (COVID-19) pandemic subjected the global population to a situation that aroused disproportionate Health Anxiety (HA). However, this association has not been explored in a systematic review or meta-analysis. The aim of this systematic review was to assess the prevalence and determining factors of HA in the general adult population during the COVID-19 pandemic. A systematic search was conducted across the databases MEDLINE, PsychINFO, Embase and Web of Science. Observational studies using the 18-item Short Health Anxiety Inventory to measure HA during the pandemic were included. A narrative synthesis and meta-analysis summarised HA levels in the general adult population, subgroups and by associated factors. Out of 4088 studies, 12 met the inclusion criteria. Meta-analyses revealed a mean HA score of 15.16 (SE = 0.415). Significantly higher HA levels were observed among females, unmarried individuals, and those with pre-existing health conditions. The HA score of 15.16 suggests elevated HA during the COVID-19 pandemic compared to pre-pandemic studies. Understanding which groups may be more affected by HA during pandemics and health crises will enable us to develop more tailored public health strategies to mitigate the psychological effects of future public health crises. Further research is needed to establish causal and longitudinal relationships.
Optimization of solar water pumping systems through a combined approach based on MPPT-Bat and DTC
Authors: Hilali Abdelilah , El marghichi Mouncef , Makhad Mohamed , Loulijat Azeddine , el Ouanjli Najib , Mossa Mahmoud A. , Almalki Mishari Metab , Alghamdi Thamer A. H.
Published: December 2024

This paper investigates enhancing the efficiency of solar water pumping systems (SWPS) by implementing a Maximum Power Point Tracking technique based on the Bat Metaheuristic Optimizer (MPPT-bat) for the photovoltaic generator (PVG) side, coupled with Direct Torque Control (DTC) for the induction motor powering the pump. Unlike traditional techniques, which make no compromise between tracking speed, oscillation and robustness. The integration of the MPPT-bat represents a significant advance, making it possible to improve PVG performance whatever the weather conditions. The main objective remains to improve the energy efficiency of this type of application by maximizing the electrical power allocated to the SWPS. At the same time, a DTC controller applied to the pump motor aims to optimize the use of the energy generated by the MPPT-bat. This intelligent approach adjusts the motor power according to the power extracted from the PVG, thus avoiding inappropriate profiles for the pumping system. The study confirms that optimizing SWPS using this approach based on MPPT-bat and DTC, significantly improves overall performances in terms of tracking error, oscillations, tracking speed and robustness, promotes more efficient pump rotation and, consequently, increases the flow rate of pumped water, and that these improvements persist under different climate conditions.