bluuebunny/crossref_metadata_2025 huggingface dataset:
Un pacto social para el crecimiento económico de Puerto Rico
Authors: Rodríguez Ríos Edgar
Published: July 2024

This paper aims to explain the advantages of creating a social pact for the development of a national public policy. A review of the literature is carried out to expose the contexts in which social pacts have been developed and the frequent problems that countries have tried to solve through this mechanism, both in Europe and in Latin America. It also explains the prerequisites and requirements for a successful social pact in terms of its creation, implementation and durability. Also, the document presents an analysis on the need and the ideal conditions for the creation of a social pact in Puerto Rico. A great economic depression, political uncertainty, poor public administration and problems in the legitimacy of the institutions have been the main characteristics of the Puerto Rican society since 2006. In this context, a mechanism for the formulation of public policy is necessary to develop an economic growth plan that is inclusive, long-term, transcends political changes, and that reflects the interest of the population. The need for a social pact increases due to the scarcity of resources faced by the government and the need to address the social problems that have arisen as a result of the economic weakness. During the last 20 years, important initiatives have been generated related to seeking for consensus and creation of dialogue for the development of public policy, in Puerto Rico there is fertile ground for the creation of a social pact that addresses one of the most important and serious problems its society faces: the poor ability to create income, employment and wealth.
La arquitectura institucional y el cumplimiento de la Agenda 2030 en Iberoamérica
Authors: Arenilla Sáez Manuel
Published: July 2024

The 2030 Agenda for Sustainable Development requires an institutional architecture that facilitates its governance and enables Iberoamerican countries to strengthen the necessary capacities to effectively meet the Sustainable Development Goals (SDG). A good institutional design is required to achieve political and social confidence, certainty and democratic stability. The conception of the State and the Administration as a platform in which numerous actors interact to achieve the common good by means of the public drive is an essential element for the success of the Agenda 2030 and their SDG. This research contemplates the combination of factors or means and administrative functions as the basis of institutional strength. From here and the analysis of academic studies, documentation of numerous agencies, and Iberoamerican countries Voluntary National Reviews, the following variables arise to be considered in the design of an adequate institutional architecture: effective leadership, institutional mechanisms, institutional capacity, intergovernmental relations and participation / communication, which have been broken down into several dimensions. The research makes a series of proposals to improve the institutional architecture for the fulfilment of the 2030 Agenda in Iberoamerica.It is decisive in leadership to attribute the impulse of the 2030 Agenda to an organism with effective powers of coordination orplanning on territorial and governmental agencies involved. It is necessary to make an effort in organizational simplification, in the integration of SDG into national planning mechanisms and the effective participation of the social actors. The budgetary and financial factor and statistics are having impact on the SDG in Iberoamerica. The territorialisation of the SDG is scarce, as also the regional and global alliances. The improvement of intergovernmental aspects and cooperation should be completed with a review of the international financing mechanisms. It is necessary to establish actual participation between social organizations and enterprises and public institutions.
La relevancia de las transferencias voluntarias de recursos federales para la consolidación de la base de apoyo del gobierno en el Congreso en Brasil
Authors: Rodrigues da Silva Eduardo , Nunes André
Published: July 2024

The literature on coalition presidentialism in Brazil considers the allocation of federal resources to the electoral bases of parliamentarians as an available tool for the Presidency to obtain support for initiatives of its interest in the National Congress. This article aims to verify the relationship between the transfer of these resources, the voluntary transfers, and the support to the Government. Two groups of deputies were separated to find out this behavior: those that vote following the Government’s orientation and those that systematically vote against it. From each group a sample of 50 deputies was selected, from which the percentage of votes obtained in the 2014 elections in each municipality was inferred. The four municipalities in which a deputy reaches proportionately more votes belong to his electoral base. Crossing this base of municipalities with data on voluntary transfers from the Federal Government, statistical tests found that the volume of federal voluntary resources received by a given municipality is related to the supportive alignment of the mayor and the governor with the Federal Government and also with the institutional capacity of the municipality administration. However, the volume of transfers received cannot be explained by virtue of whether or not the municipality is the electoral base of a federal deputy aligned or facing opposition to the Federal Executive.
La remunicipalización de la gestión del agua en España: barreras legales frente a narrativas exitosas
Authors: Villoria Manuel , Navarro Carmen , Pano Puey Esther
Published: July 2024

As a result of the austerity policies applied in Europe after the global economic crisis, some of the New Public Management proposals were reactivated, particularly the outsourcing of public services. Given the negative and unforeseen consequences, observed in many cases after its implementation, a set of opposite reforms emerged as the economic situation improved. Re-municipalization strategies or return to public hands of previously privatized or outsourced services appear, especially at the municipal level. However, in countries like Spain, there is a gap between the abundance of political speeches that support re-municipalization and the low effectiveness of these reforms. Taking water management as a case of empirical analysis, this work deepens in these processes, questioning their scope, trajectory and the reasons of the gap.
¿Pueden producirse las innovaciones de la Cuarta Revolución Tecnológica al interior de los sistemas de administración pública?
Authors: Schweinheim Guillermo
Published: July 2024

Theoretical approaches and applied research on the relationship between technological changes and innovations and public administration are usually characterized by a type of work program that explains the changes in public administration based on the technological transformations and innovations taking place in “society”. However, comparative experience, and also that of Latin America, shows how in multiple occasions the technological changes and innovations produced within public administration systems have impacted on social processes, re-enrolling economic and social actors, including large business actors, in these innovations and producing changes with intensive use of ICT which transformed social associations at the national, continental and global levels. The article explores the cases of changes in financial administration, procurement and contracting and public revenue systems produced in Latin America, using the science and technology studies of the Network Actor Theory. It addresses its implications in relation to the transformations known as the fourth industrial revolution, the different ways of dealing with the processes of change, innovation, adaptation or modernization of public administrations, and the way in which innovation in State administrations, especially in the fourth technological revolution, can lead to broader social transformations.
Organizaciones criminales digitales: conocerlas para enfrentar su desafío
Authors: Depetris Jorge Augusto
Published: July 2024

Criminal organizations have mutated from conventional to digital, due to the new technological paradigm and globalization. This turns them into an important challenge for the national States. This article analyzes digital criminal organizations from the perspective of the State and tries to address what they are, how they work and why they develop or shrink. The aim is to better understand the object and analyze their weaknesses. Knowing them is the first step to develop public strategies and tools to face the challenge they represent for peace and democracy.
Research on the Innovative Development Model of the Chinese Museum Cultural Creative Industry in the New Media Era
Authors: Mingzhen Wang Mingzhen Wang ,   Northeast Asian Arts and Cultural Management Association
Published: July 2024

Purpose – The purpose of this study is to clarify the development status of museum cultural creative industry in the
new media era, and make contributions to the development of museum cultural creative industry in the new media
era. Use new media technology to enhance the innovation and development space of museum culture.
Design/Methodology/Approach – This study uses the method of literature research and case study, combined
with the Palace Museum, Suzhou Museum and other large museums for in-depth analysis. By combing national
policies and industry norms, the development and sale of cultural and creative products, and the application of
digital technology, the paper summarizes the problems in the development and sale of museum cultural and creative
products.
Findings – It is necessary to grasp the opportunities for the development of cultural and creative industries, innovate
the development concept of museums, and implement industrial development policies. From the application of digital
technology, market-oriented operation and other aspects to accelerate the pace of museum cultural and creative
industry development. At the same time, establish brand awareness, multi-channel marketing, and promote the
comprehensive development of museum cultural and creative industry.
Research Implications – This study enriches the theoretical scope of new media development. In addition, through
the analysis of the development status of the cultural and creative industry of museums, it more clearly indicates the
practical difficulties faced by the development of the cultural and creative industry of museums, and points out the
direction for the development of the cultural and creative industry of museums in the future.
Exploring the Path to Dance Industrialization: A Case Study of Promoting Chinese Dance Teaching Materials
Authors: Qian Guo Qian Guo ,   Northeast Asian Arts and Cultural Management Association
Published: July 2024

Purpose – The study presents an in-depth investigation into the industrialization pathways of dance, with a focus on
the promotion of Chinese dance textbooks, as a symbol of cultural exchange in the era of globalization. The aim is to
explore the potential and methods of industrializing dance while emphasizing its significance for the dissemination of
Chinese culture.
Design/Methodology/Approach – The paper examines the intersection of artistic creation and commercial operation,
proposing a strategy that harmonizes the two through the inductive summary of practical bases and rational thinking,
accompanied by forward-looking speculation. It discusses the critical role of Chinese dance textbook promotion in the
industrialization of dance and sets specific developmental goals over different periods: short-term (2 years), medium-term (10 years), and long-term (20 years).
Findings – By setting stage-specific targets for the dissemination of Chinese dance textbooks, this research not
only offers a practical guide to the industrialization of dance but also proposes beneficial strategies and insights for
promoting Chinese dance culture. The study articulates detailed promotional strategies across various spectrums like
market expansion, unique selling propositions, enrollment diversification, and performance marketing, aiming to
widen the influence of Chinese dance textbooks effectively.
Research Implications – This paper enriches the theoretical and practical understanding of dance industrialization.
By emphasizing Chinese dance as an integral component of Chinese culture, the study advocates for dance education
and industrial models, contributing to the diversification of global cultural development. It also anticipates the
prospective landscape of promoting Chinese dance textbooks and cultural propagation through industrialization.
Eco-Friendly Remediation: Tea Leaves and Fibres as Adsorbents for High Cobalt Concentrations; Thermodynamics, Isotherms and Kinetic Studies
Authors: E. Etim Emmanuel , Yakubu Shedrach , C. Onaji Emmanuel
Published: July 2024

Increasing industrialization has produced huge amounts of liquid effluents, which are a key source of ecological unrest in diverse ecosystems. The high toxicity level of cobalt in surface water has drawn a lot ofattention; hence,a low-cost adsorbent made from leaves and fibres of Camellia sinensis has been developed to remove cobalt from wastewater. The kinetics of the pseudo-first and second-order sorption interaction, as well as the physicochemical parameters of the precursor adsorbent, was investigated. There was a linear relationship between Cobalt uptake and biosorbent dosage under ideal conditions; the optimum dosage was 4 g. Between 10 to 40 minutes of contact time, clearance of cobalt was greater than 90 per cent. The Gibb’s free energy (∆Go) at various temperatures ranges from -9980 to -1020, indicating a spontaneous system, viable for both parts of the precursor adsorbent. The entropy change (∆So) was found to be +31.05 and +35.12 for tea leaves and fibre respectively, implying a highly disordered biosorption interface. The enthalpy (∆Ho) was found to be-8.58 and -10.03 for tea leaves and fibres hence, an exothermic system was suggested by the enthalpy with a second order kinetics. Therefore, Camellia sinensis is a suitable adsorbent for the effective removal of high cobalt concentrations in wastewater.
Hubungan Pengetahuan Kesehatan Reproduksi Terhadap Perilaku Seks Pranikah Mahasiswa Kos-Kosan di Kecamatan Batalaiworu, Kabupaten Muna
Authors: Dewi Dewi Rahmawati , Saing Fatmawati M. , Sarumi Rasniah
Published: July 2024

Perilaku seks pranikah merupakan masalah yang sangat serius untuk mendapat penanganan serius di Indonesia. Perilaku seks pranikah berdampak pada peningkatan kejadian bunuh diri remaja, kekerasan antar pribadi, meningkatnya angka penyakit menular seksual seperti HIV/AIDS serta penyakit-penyakit menular lainnya. asalah  kehamilanpada  usia  remaja  juga masih  cukup  tinggi  dimana  ada  44  kelahiran  per  1000  untuk  anak  perempuan  berusia  15 hingga  19  tahun. Tujuan penelitian: Untuk  mempelajari  hubungan  pengetahuan  tentang kesehatan  reproduksi  dengan  perilaku  seksual  pada  remaja di Kelurahan Batalaiworu. Metode  penelitian: menggunakan  desain cross-sectional.sampel   dalam  peneltian  ini sebanyak  87  orang  diambil  menggunakan  teknik Purpusive Random  Sampling.  Data  yang diperoleh  selanjutnya,  diolah  dan  dianalisis  dengan  menggunakan analisis  univariat  dan analisis   bivariat   menggunakan   analisis chi-square. Hasil penelitian:  menunjukkan  bahwa  dari  95  responden  terdapat  41  respoden  yang  pernah melakukan perilaku seksual dan 54 responden yang tidak pernah melakukan perilaku seksual. Dari 95 responden terdapat 30 respoden yang mempunyai pengetahuan kurang, 30 responden mempunyai    pengetahuan    cukup    dan    35    responden    mempunyai    pengetahuan    baik. Kesimpulan: Ada  hubungan  pengetahuan  tentang  kesehatan  reproduksi  dengan perilaku seksual  remaja kos-kosan  di Kelurahan Batalaiworu dengan  kategori  hubungan  sedang. Kampus diharapkan  dapat  membentuk  dan  meningkatkan  layanan  informasi  dan  konseling  kepada mahasiswa.
SOSIALISASI UPAYA REVITALISASI PENDIDIKAN BIOLOGI UNTUK MEWUJUDKAN SDGS DI INDONESIA
Authors: Pongtambing Yulita Sirinti , Ristiana Evi , Manapa Esther Sanda , Sampetoding Eliyah Acantha Manapa
Published: July 2024

Pendidikan memainkan peran penting dalam mencapai SDGs. Pendidikan sangat penting untuk memberdayakan individu, mengembangkan kewarganegaraan global, dan mengatasi tantangan-tantangan dunia yang paling mendesak. Kegiatan Sosialisasi ini bertujuan untuk memberikan pemahaman tentang SDGs dan peran Dosen Muda. Dalam hal ini, fokus yang dibahas pada laporan pengabdian adalah mengenai Pendidikan Biologi. Pada topik Pendidikan Biologi, topik yang disampaikan oleh Narasumber yakni (1) SDGs dan Pendidikan, (2) Pendidikan Biologi, (3) Peran Dosen Muda dan (4) Harapan menyambut 2030 di Indonesia. Peserta yang hadir mencapai 130 orang dan cukup antusias bertanya pada kolom chat pada saat berlangsungkan kegiatan.
DOSEN FARMASI MENYUARAKAN KESADARAN PENGGUNAAN ANTIBIOTIK DALAM MEMBANGUN PENGETAHUAN WARGA TUGU DEPOK
Authors: Refdanita  , Syafriana Vilya , Zahra Aishah Az , Arsa Imalia , Teodhora  , Wulandari Ainun , Febriani Amelia , Kusuma Ika Maruya , Musnelina Lili , Sholikhah Munawarohthus , Widyapratiwi Ritha , Hamida Fathin
Published: July 2024

Antibiotika memainkan peran penting dalam pengobatan infeksi bakteri serius. Namun, penggunaannya yang tidak tepat dan berlebihan telah menjadi masalah global yang mengkhawatirkan, meningkatkan risiko resistensi antibiotika yang mengancam efektivitas pengobatan. Di wilayah RT 08 RW 05 Kelurahan Tugu, Kecamatan Cimanggis, Kota Depok, kurangnya pemahaman masyarakat tentang penggunaan antibiotika yang benar menjadi perhatian utama. Dosen farmasi dari Institut Sains dan Teknologi Nasional melaksanakan kegiatan pengabdian masyarakat untuk mengedukasi warga setempat tentang penggunaan antibiotika yang bijaksana. Kegiatan ini meliputi edukasi, penyuluhan, dan pengembangan materi pendidikan yang mudah dipahami, seperti leaflet. Berdasarkan kuesioner yang diisi oleh 30 peserta, ditemukan bahwa 87,3% peserta mengetahui tentang antibiotika, namun 58,5% masih salah paham bahwa dosis antibiotika bisa dikurangi jika gejala membaik. Hasil ini menunjukkan peningkatan pemahaman, tetapi masih ada kesalahpahaman yang perlu diperbaiki. Kegiatan ini diharapkan dapat menciptakan perubahan perilaku jangka panjang dalam penggunaan antibiotika yang tepat, serta menjadi contoh yang dapat direplikasi di berbagai wilayah lainnya.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE NUMBER HEAD TOGETHER DI SMP NEGERI I SARMI
Authors: Sirampun Elsi , Kho Ronaldo , Lumbantobing Happy , Napitupulu Bettisari , Hadiyanti Yosefin Rianita , Tandililing Pitriana , Manurung Mayor M.H. , Panjaitan Agnes Teresa
Published: July 2024

Kegiatan pengabdian ini bertujuan untuk mengatasi permasalahan dalam pembelajaran. Berdasarkan hasil observasi pada saat kegiatan belajar matematika di kelas VIII E SMP Negeri 1 Sarmi bersama guru mata pelajaran matematika, diperoleh beberapa masalah yang terjadi pada saat proses belajar mengajar berlangsung yaitu pembelajaran yang diberikan oleh guru masih menggunakan pembelajaran dengan metode ceramah yang berpusat pada guru sehingga peserta didik kurang aktif baik itu bertanya ataupun menjawab pertanyaan. Berdasarkan hasil pengamatan diatas maka penerapan model pembelajaran merupakan solusi yang dapat gunakan oleh guru dalam mengelola kelas menjadi lebih menyenangkan dan lebih mengutamakan keaktifan peserta didik serta memberikan kesempatan kepada peserta didik untuk mengembangkan potensinya secara maksimal. Model pembelajaran yang dimaksud adalah model pembelajaran kooperatif tipe Number Head Together (NHT). Berdasarkan hasil Kegiatan Pengabdian Kepada Masyarakat di kelas VIII E SMP Negeri 1 Sarmi diperoleh pertama Keaktifan peserta didik dilihat dari penilaian sikap setelah dilakukan pembelajaran dengan menggunakan model pembelajaran kooperatif tipe pada materi barisan aritmatika di kelas VIII SMP Negeri 1 Sarmi  baik; kedua Hasil belajar peserta didik setelah dilakukan proses pembelajaran dengan menggunakan model pembelajaran kooperatif tipe Number Head Together (NHT) pada materi barisan aritmatika di kelas VIII SMP Negeri 1 Sarmi mengalami peningkatan dilihat dari hasil pretes dan posttest.
Przegląd decyzji Prezesa UOKiK w sprawach antykonsumenckich praktyk rynkowych dotyczących usług finansowych wydanych w 2023 roku
Authors:   Uniwersytet Wrocławski, Rutkowska-Tomaszewska Edyta , Zwaliński Artur ,   Departament Ochrony Zbiorowych Interesów Konsumentów Urzędu Ochrony Konkurencji i Konsumentów
Published: July 2024

W artykule dokonano przeglądu decyzji Prezesa Urzędu Ochrony Konkurencji i Konsumentów (dalej: Prezes UOKiK, Prezes Urzędu) wydanych w okresie od 1 stycznia do 31 grudnia 2023 roku. Przeanalizowano i oceniono wszystkie decyzje wydane przez Prezesa UOKiK we wskazanym wyżej okresie. Dokonano ich podziału na dwie zasadnicze kategorie wynikające z właściwości Prezesa UOKiK do wydawania decyzji w sprawach antykonsumenckich praktyk rynkowych, a mianowicie na decyzje w sprawach naruszenia zbiorowych interesów konsumentów oraz na decyzje w sprawie stosowania niedozwolonych postanowień umownych we wzorcach umów, a następnie w ich ramach na grupy według wiodących problemów szczegółowych. W zakresie stosowania klauzul niedozwolonych są to przede wszystkim decyzje dotyczące: opłat alokacyjnych stosowanych w umowach ubezpieczeń na życie z funduszem inwestycyjnym UFK, indywidualnie negocjowanego charakteru postanowień umowy, jej dopasowania do potrzeb konsumenta, zrozumiałości i braku jakikolwiek zastrzeżeń. W przypadku decyzji w sprawach naruszeń zbiorowych interesów konsumentów wyodrębniono następujące kategorie decyzji, a mianowicie dotyczące: nieuczciwych praktyk rynkowych wprowadzających w błąd (m.in. co do informacji o ryzyku, w ramach prowadzących akcji promocyjnych, co do wyników wyszukiwania), naruszenia przepisów ustawy o kredycie konsumenckim, ograniczenia możliwości składania przez konsumentów wniosków o zawieszenie spłaty kredytu hipotecznego (ustawowe wakacje kredytowe), wprowadzenia w błąd co do jednostronnej zmiany postanowień umownych uznanych w innej decyzji za niedozwolone, przyjęcia oferty ubezpieczeniowej bez aktywnej zgody konsumenta, braku właściwego nadzoru nad agentami wprowadzającymi w błąd konsumentów.
Eye-Tracking for Examining Nurses’ Attention During Cardiac Arrest Simulations: A Feasibility and Acceptability Study
Authors: Lavoie Patrick , Lapierre Alexandra , Khetir Imène , Doherty Amélie , Thibodeau-Jarry Nicolas , Rousseau-Saine Nicolas , Benhannache Rania , Crétaz Maude , Mailhot Tanya
Published: July 2024

Introduction: Eye-tracking offers a distinctive opportunity to assess nurses’ clinical decision-making in simulation. Although its feasibility has been established in various scenarios, most studies have focused on a single participant, typically a physician in a leadership role. The application of eye-tracking in the challenging context of in-hospital cardiac arrest (IHCA) simulations, where nurses juggle diverse roles and undertake physical tasks such as chest compressions, has yet to be explored.

Objectives: This study aimed to assess the feasibility and acceptability of eye-tracking with nurses’ during IHCA simulations. Additionally, the study aimed to describe eye-tracking metrics based on different resuscitation roles and to explore the relationship between eye-tracking metrics to pinpoint the most informative metrics for the design of future studies.

Methods: In this single-group observational study, 56 newly hired nurses wore eye-tracking glasses during IHCA simulations. The primary feasibility criterion was the proportion of usable eye-tracking data. Secondary criteria included recruitment rate, calibration time, and glasses acceptability. The relationship among eye-tracking metrics was investigated through correlation analyses.

Results: Calibration of the devices was rapid, and 85.7% of the data was usable. The glasses were comfortable, non-distracting, and did not impede nurses’ vision or performance. Data were mapped for five areas of interest: the patient’s head and chest, cardiac monitor, teammates, and resuscitation cart. Eye-tracking metrics exhibited variations based on resuscitation roles. Fixation count, fixation duration, and time to first fixation appeared to be the most informative metrics in IHCA simulation.

Discussion and conclusion: These findings demonstrate the feasibility and acceptability of analyzing nurses’ eye-tracking data during IHCA simulations using a role-based approach. Future research should explore correlations with additional attention measures to enhance our understanding of nurse decision-making during cardiac arrest and improve educational strategies and outcomes.
The Role of Attachment in Parents’ Perception of the Impact of Pediatric Cancer on Their Relationship
Authors: Laplante Sabrina , Beaulieu Noémie , Sultan Serge , Péloquin Katherine
Published: July 2024

Introduction: The cancer diagnosis of a child is an extremely challenging event that necessitates adjustments for parents at individual, family, and couple levels. To our knowledge, the factors that may explain parents’ relationship adjustments in the context of pediatric cancer remain under-documented.

Objectives: This dyadic study (1) described the perceived impact of pediatric cancer on parents’ relationship and (2) explored the relationship between attachment insecurities (both anxiety and avoidance) in both parents and their perception of how pediatric cancer influenced different facets of their relationship.

Method: Fifty-one mixed-sex couples whose child has received treatment for cancer (whether the treatment was ongoing or completed) within the past two years, completed online questionnaires.

Results: Path analyses, based on the Actor-Partner Interdependence Model, showed that higher attachment insecurities in mothers and fathers were associated with their own perception of a more negative impact of cancer on their relationship regarding the quality of partner support (actor effect). Surprisingly, higher attachment insecurities in mothers and fathers were also linked to their partner’s perception of a more positive impact of their child’s illness on their relationship functioning (partner effects).

Discussion and conclusion: These results suggest that attachment insecurities not always have solely negative impacts. In extreme situations, such as pediatric cancer (at least in the early years of post-diagnosis), attachment-related anxiety and avoidance of parents could protect the relationship from certain difficulties.
MTV Brasil: repertório musical e construção de uma juventude televisionada (1990)
Authors: Oliveira Carlos Eduardo Pereira de
Published: July 2024

Objective/context: this article analyzes the construction of youth representations through the musical repertoire produced by MTV Brasil in its first year. The objective is to understand the musical segments most explored by the broadcaster during this period, as well as how to articulate their protagonism in the transformation of the “youth music” category, with a singular impact on Brazilian youth culture. mtv was a television channel aimed at young audiences, which started in the United States in 1981 and arrived in Brazil in 1990 through Grupo Abril, a national media conglomerate. The broadcast on Brazilian soil is based on the American format, showing musical videos from artists and specific musical segments, with a strong attraction for consumption in this sector of the population. Methodology: considering music as a social marker, this study analyzes the specific repertoire of musical segments and artists produced by the broadcaster as a means of identification. Therefore, an examination based on the first musical videos by Brazilian artists produced by the broadcaster and broadcast in its first year is proposed. Originality: the level of importance of certain media or media programs in the constitution of the identities of social agents, especially in the development of juvenile identities in the recent past, is only a little analyzed. Conclusions: it can be concluded that MTV operated as a musical authority for young people, acting as a curator of what they should consume to perform their youthful condition, acting as an artificer of youth. The broadcaster was based on its initial repertoire among a group of artists linked to rock music, with a strong influence on the recording industry in the 1990s and a decisive impact on Brazilian youth.
“¡Eso no nos representa!” Historia, contexto(s) y representación en el Monumento Nacional a la Memoria de las Víctimas del Holocausto Judío de Buenos Aires, Argentina
Authors: Kahan Emmanuel Nicolás
Published: July 2024

Objective/Context: In the field of Holocaust studies, the Latin American experience has occupied a liminal space. Even when the global character assumed by its forms of remembrance is widely accepted, little attention has been paid to the national cases of this region. This paper deals with a specific national case through the construction record of the National Monument to the Victims of the Jewish Holocaust, located in the city of Buenos Aires, Argentina. The present research reveals the legal and administrative process that accompanied its gestation, the recognition of the actors that intervened throughout the period, and, finally, the character and debates that the architecture of the pantheon provoked. This cycle, which lasted a little more than two decades, allows us to qualify the meaning of the global character of Holocaust memory by considering how this experience was redefined in a national context. Methodology: For this research, qualitative techniques are used in the analysis of the legislative and patrimonial records, journalistic sources, interviews with involved actors, and a documentary film called “Monument,” which aims to give an account of the history of its construction and the representational matrix of that memorial. Originality: Although there have been, in recent years, some works that addressed the memory of the Holocaust in Argentina, they focused on various cultural media: literature, film, and testimonial narratives. This paper addresses an object whose materiality is different—monumental—and which was conceived as a public policy of commemorative character. The analysis of the construction of this memorial pantheon allows recognition of how the transnational dimensions of Holocaust remembrance intersected with aspects of the Argentine political process of the last twenty years. Conclusions: The analysis of the construction process and the materiality assumed by its architecture demonstrate, first, how the global dimensions of Holocaust remembrance interact with local contexts and, second, the tensions raised between the actors and organizations that promote its memory and the victims of Nazi persecution in Argentina.
Revealing a hidden conducting state by manipulating the intracellular domains in KV10.1 exposes the coupling between two gating mechanisms
Authors: Abdelaziz Reham , Tomczak Adam P , Neef Andreas , Pardo Luis A
Published: July 2024

The
KCNH
family of potassium channels serves relevant physiological functions in both excitable and non-excitable cells, reflected in the massive consequences of mutations or pharmacological manipulation of their function. This group of channels shares structural homology with other voltage-gated K
+
channels, but the mechanisms of gating in this family show significant differences with respect to the canonical electromechanical coupling in these molecules. In particular, the large intracellular domains of
KCNH
channels play a crucial role in gating that is still only partly understood. Using
KCNH1
(K
V
10.1) as a model, we have characterized the behavior of a series of modified channels that could not be explained by the current models. With electrophysiological and biochemical methods combined with mathematical modeling, we show that the uncovering of an open state can explain the behavior of the mutants. This open state, which is not detectable in wild-type channels, appears to lack the rapid flicker block of the conventional open state. Because it is accessed from deep closed states, it elucidates intermediate gating events well ahead of channel opening in the wild type. This allowed us to study gating steps prior to opening, which, for example, explain the mechanism of gating inhibition by Ca
2+
-Calmodulin and generate a model that describes the characteristic features of
KCNH
channels gating.
Neonatal sensitivity to vocal emotions: A milestone at 37 weeks of gestational age
Authors: Hou Xinlin , Zhang Peng , Mo Licheng , Peng Cheng , Zhang Dandan
Published: July 2024

Emotional responsiveness in neonates, particularly their ability to discern vocal emotions, plays an evolutionarily adaptive role in human communication and adaptive behaviors. The developmental trajectory of emotional sensitivity in neonates is a crucial area of inquiry for understanding the foundations of early social-emotional functioning. However, the precise onset of this sensitivity in neonates and its relationship with gestational age (GA) remain subjects of investigation. In a study involving 120 healthy neonates categorized into six groups based on their GA (ranging from 35 and 40 weeks), we delved into their emotional responses to vocal stimuli. These stimuli encompassed disyllables with happy and neutral prosodies, alongside acoustically matched nonvocal control sounds. The assessments occurred during natural sleep states in neonates, utilizing the odd-ball paradigm and event-related potentials. The results unveil a distinct developmental milestone at 37 weeks GA, marking the point at which neonates exhibit heightened perceptual acuity for emotional vocal expressions. This newfound ability is substantiated by the presence of the mismatch response, akin to an initial form of adult mismatch negativity, elicited in response to positive emotional vocal prosody. Notably, this perceptual shift’s specificity becomes evident when no such discrimination is observed in acoustically matched control sounds. Neonates born before 37 weeks GA do not display this level of discrimination ability. This critical developmental milestone carries significant implications for our understanding of early social-emotional development, shedding light on the role of gestational age in shaping early perceptual abilities. Moreover, it introduces the potential for a valuable screening tool in the context of autism, which is characterized by atypical social-emotional functions. This study makes a substantial contribution to the broader field of developmental neuroscience and holds promise for early intervention in neurodevelopmental disorders.
Treacle’s ability to form liquid phase condensates is essential for nucleolar fibrillar center assembly, efficient rRNA transcription and processing, and rRNA gene repair
Authors: Velichko Artem K , Kovina Anastasia P , Luzhin Artem V , Petrova Nadezhda V , Deriglazov Dmitry A , Kazakov Eugene P , Kireev Igor I , Razin Sergey V , Kantidze Omar L
Published: July 2024

We investigated the role of the nucleolar protein Treacle in organizing and regulating the nucleolus in human cells. Our results support Treacle’s capacity to form liquid-phase condensates through electrostatic interactions among molecules. The formation of these biomolecular condensates is crucial for segregating nucleolar fibrillar centers from the dense fibrillar component, as well as ensuring high levels of rRNA gene transcription and accurate pre-rRNA processing. The presence of both the central and C-terminal domains of Treacle is necessary for the creation of liquid-phase condensates. Initiation of phase separation is attributed to the C-terminal domain, while the central domain, characterized by repeated stretches of alternatively charged amino-acid residues, is vital for maintaining the condensate’s liquid state. When mutant forms of Treacle, incapable of forming liquid-phase condensates, are overexpressed in cells, it compromises the establishment of fibrillar centers, leading to the suppression of rRNA transcription and disruption of its processing. Additionally, these mutant forms fail to recruit TOPBP1, resulting in the suppression of the DNA damage response in the nucleolus.
A genome wide CRISPR/Cas9 screen identifies calreticulin as a selective repressor of ATF6α
Authors: Tung Joanne , Huang Lei , George Ginto , Harding Heather P , Ron David , Ordóñez Adriana
Published: July 2024

Activating transcription factor 6 (ATF6) is one of three endoplasmic reticulum (ER) transmembrane stress sensors that mediate the unfolded protein response (UPR). Despite its crucial role in long-term ER stress adaptation, regulation of ATF6 alpha (α) signalling remains poorly understood, possibly because its activation involves ER-to-Golgi and nuclear trafficking. Here, we generated an ATF6α/IRE1 dual UPR reporter CHO-K1 cell line and performed an unbiased genome-wide CRISPR/Cas9 mutagenesis screen to systematically profile genetic factors that specifically contribute to ATF6α signalling in the presence and absence of ER stress. The screen identified both anticipated and new candidate genes that regulate ATF6α activation. Among these, calreticulin (CRT), a key ER luminal chaperone, selectively repressed ATF6α signalling: Cells lacking CRT constitutively activated a BiP::sfGFP ATF6α-dependent reporter, had higher BiP levels and an increased rate of trafficking and processing of ATF6α. Purified CRT interacted with the luminal domain of ATF6α
in vitro
and the two proteins co-immunoprecipitated from cell lysates. CRT depletion exposed a negative feedback loop implicating ATF6α in repressing IRE1 activity basally and overexpression of CRT reversed this repression. Our findings indicate that CRT, beyond its known role as a chaperone, also serves as an ER repressor of ATF6α to selectively regulate one arm of the UPR.
The gut contractile organoid: a novel model for studying the gut motility regulated by coordinating signals between interstitial cells of Cajal and smooth muscles
Authors: Yagasaki Rei , Nakamura Ryo , Shikaya Yuuki , Tadokoro Ryosuke , Hao Ruolin , Wang Zhe , Eiraku Mototsugu , Inaba Masafumi , Takahashi Yoshiko
Published: July 2024

The gut undergoes peristaltic movements regulated by intricate cellular interactions. However, they have poorly been explored due to a lack of model system. We here developed a novel contractile organoid that is derived from the muscle layer of chicken embryonic hindgut. The organoid contained smooth muscle cells (SMCs) and interstitial cells of Cajal (ICCs; pacemaker) with few enteric neurons, and underwent periodic contractions. The organoid formed by self-organization with morphological arrangements of ICCs (internal) and SMCs (peripheral), allowing identification of these cells in live. GCaMP-Ca
2+
imaging analyses revealed that Ca
2+
transients between ICC- ICC, SMC-SMC or SMC-ICC were markedly coordinated. Pharmacological studies further showed that gap junctions play a role in ICC-to-SMC signaling, and also possible feedback from SMC’s contraction to ICC’s pace-making activities. In addition, two organoids with different rhythm became synchronized when mediated by SMCs, unveiling a novel contribution of SMCs to ICC’s pace-making. The gut contractile organoid developed in this study offers a useful model to understand the mechanisms underlying the rhythm coordination between/among ICCs and SMCs during gut peristaltic movements.
Mapping the fly nerve cord
Authors: Seggewisse Anna , Winding Michael
Published: July 2024

The first neuronal wiring diagram of an insect nerve cord, which includes biological information on cell type and organisation, enables further investigation into premotor circuit function.
The role of melatonergic system in intervertebral disc degeneration and its association with low back pain: a clinical study
Authors: Chen Chong , Deng Zongyuan , Yu Zhengran , Chen Yifan , Yu Tao , Liang Changxiang , Ye Yongyu , Huang Yongxiong , Lyu Feng-Juan , Liang Guoyan , Chang Yunbing
Published: July 2024

Objective

The mechanisms of intervertebral disc degeneration (IVDD) in low back pain (LBP) patients are multiples. In this study, we attempt to investigate whether melatonergic system plays a potential role in IVDD patients with LBP by analyzing their clinical specimens. The fucus will be given to the correlation between the melatonin receptor expression and intervertebral disc tissue apoptosis.

Methods

In this clinical study, 107 lumbar intervertebral disc nucleus pulposus (NP) specimens from patients with LBP were collected with patients’ consents. The disc height (DH) discrepancy ratio, range of motion and sagittal parameters of the pathological plane were measured and Pfirrmann grade was used to classified the grades of IVDD level. Discs at grades 1–3 were served as normal control and grades 4–5 were considered as IVDD. The expression levels of melatonin receptor 1A (MT1) and 1B (MT2) were measured by immunohistochemistry. The apoptosis of NP was assessed using TUNEL staining. Their potential associations among MT1/2, DH, apoptosis, sagittal parameters with IVDD and LBP were evaluated with statistical analysis.

Results

The incidence of IVDD was positively associated with age and negatively related to VAS scores for LBP (p < 0.001). Patients with higher degree of IVDD also have higher DH discrepancy ratio (p < 0.001), higher prevalence of lumbar instability (p = 0.003) and higher cell apoptosis compared to the control. Nevertheless, no statistically significant correlation was identified between Pfirrmann grade and lumbar sagittal parameters. MT1 and MT2 both were highly expressed in the NP tissues. Importantly, MT1 expression but not MT2 was significantly increased in the intervertebral disc tissue of patients with IVDD and its level correlated well with cell apoptosis level and the severity of IVDD as well as lower VAS scores for LBP.

Conclusion

The highly elevated MT1 expression was found in NP tissues of patients with IVDD and LBP compared to the control. This phenomenon probably reflects the compensating response of the body to the pathological alteration of the IVDD and LBP. Therefore, these findings provide the novel information to use selective agonists of MT1 to target IVDD and LBP clinically.
Innovative infrastructure to access Brazilian fungal diversity using deep learning
Authors: Chaves Thiago , Santos Xavier Joicymara , Gonçalves dos Santos Alfeu , Martins-Cunha Kelmer , Karstedt Fernanda , Kossmann Thiago , Sourell Susanne , Leopoldo Eloisa , Fortuna Ferreira Miriam Nathalie , Farias Roger , Titton Mahatmã , Alves-Silva Genivaldo , Bittencourt Felipe , Bortolini Dener , Gumboski Emerson L. , von Wangenheim Aldo , Góes-Neto Aristóteles , Drechsler-Santos Elisandro Ricardo
Published: July 2024

In the present investigation, we employ a novel and meticulously structured database assembled by experts, encompassing macrofungi field-collected in Brazil, featuring upwards of 13,894 photographs representing 505 distinct species. The purpose of utilizing this database is twofold: firstly, to furnish training and validation for convolutional neural networks (CNNs) with the capacity for autonomous identification of macrofungal species; secondly, to develop a sophisticated mobile application replete with an advanced user interface. This interface is specifically crafted to acquire images, and, utilizing the image recognition capabilities afforded by the trained CNN, proffer potential identifications for the macrofungal species depicted therein. Such technological advancements democratize access to the Brazilian Funga, thereby enhancing public engagement and knowledge dissemination, and also facilitating contributions from the populace to the expanding body of knowledge concerning the conservation of macrofungal species of Brazil.
A comparison of antibiotic resistance genes and mobile genetic elements in wild and captive Himalayan vultures
Authors: Zhai Jundie , Wang You , Tang Boyu , Zheng Sisi , He Shunfu , Zhao Wenxin , Lin Jun , Li Feng , Bao Yuzi , Lancuo Zhuoma , Liu Chuanfa , Wang Wen
Published: July 2024

As the most widely distributed scavenger birds on the Qinghai-Tibetan Plateau, Himalayan vultures (Gyps himalayensis) feed on the carcasses of various wild and domestic animals, facing the dual selection pressure of pathogens and antibiotics and are suitable biological sentinel species for monitoring antibiotic resistance genes (ARGs). This study used metagenomic sequencing to comparatively investigate the ARGs and mobile genetic elements (MGEs) of wild and captive Himalayan vultures. Overall, the resistome of Himalayan vultures contained 414 ARG subtypes resistant to 20 ARG types, with abundances ranging from 0.01 to 1,493.60 ppm. The most abundant resistance type was beta-lactam (175 subtypes), followed by multidrug resistance genes with 68 subtypes. Decreases in the abundance of macrolide-lincosamide-streptogramin (MLS) resistance genes were observed in the wild group compared with the zoo group. A total of 75 genera (five phyla) of bacteria were predicted to be the hosts of ARGs in Himalayan vultures, and the clinical (102 ARGs) and high-risk ARGs (35 Rank I and 56 Rank II ARGs) were also analyzed. Among these ARGs, twenty-two clinical ARGs, nine Rank I ARG subtypes, sixteen Rank II ARG subtypes were found to differ significantly between the two groups. Five types of MGEs (128 subtypes) were found in Himalayan vultures. Plasmids (62 subtypes) and transposases (44 subtypes) were found to be the main MGE types. Efflux pump and antibiotic deactivation were the main resistance mechanisms of ARGs in Himalayan vultures. Decreases in the abundance of cellular protection were identified in wild Himalayan vultures compared with the captive Himalayan vultures. Procrustes analysis and the co-occurrence networks analysis revealed different patterns of correlations among gut microbes, ARGs, and MGEs in wild and captive Himalayan vultures. This study is the first step in describing the characterization of the ARGs in the gut of Himalayan vultures and highlights the need to pay more attention to scavenging birds.
Desafios e estratégias na gestão de bens móveis permanentes: um estudo sobre o controle interno dos coordenadores de patrimônio em instituições federais de ensino
Authors: Sá Rosimere Gomes de , Mendes Bruno Santos , Soares Michel S , Malta Junior Regis Renner Vasconcelos , Costa Neto Valdemar Alves da , Rodrigues Dielle de Oliveira Filocre
Published: July 2024

Este artigo investiga a eficácia do controle interno realizado pelos coordenadores de patrimônio na gestão e localização dos bens móveis permanentes em uma Instituição Federal de Ensino. A questão central é entender como esses controles impactam a gestão patrimonial. Utilizou-se uma abordagem qualitativa, com um estudo de caso único em uma instituição composta por uma Reitoria e nove unidades gestoras. A coleta de dados envolveu entrevistas, observações e análise de documentos institucionais, como manuais de gestão patrimonial e inventário. A análise dos dados seguiu a técnica de análise de conteúdo de Bardin. Os resultados indicam variações significativas nas práticas de controle interno entre as unidades gestoras, desafios na manutenção de registros precisos e atualizados, e a necessidade de maior capacitação e recursos adequados. A comunicação interna e a integração dos sistemas de informação também foram identificadas como áreas críticas. Foram propostas melhorias, incluindo programas de capacitação contínua, desenvolvimento de um sistema centralizado de gestão patrimonial, e medidas proativas de monitoramento e auditoria. Conclui-se que a implementação dessas recomendações pode fortalecer significativamente o controle interno e a gestão eficaz dos bens móveis permanentes, promovendo maior transparência e responsabilidade na administração pública.