bluuebunny/crossref_metadata_2025 huggingface dataset:
Computer Aided Drug Design
Authors: Ms. Shubhangi Manikpuriya  , Mr. Shubham Girnare  , Mr. Akash Shinde  , Dr. Gajanan Sanap
Published: February 2022

Computational approaches in drug style, discovery and admiration. Generally, drug discovery takes an extended Duration of your time amount Ni twelve year and billon of capital. It includes the making of recent molecules, docking Molecules to focus on macromolecule, analyzing molecular interaction, estimating binding strength and drug properties. Computer power-assisted Drug planning (CADD) is value effective and freed from some biological trials. It mainly consists of 2 styles of drug style that’s structure -based drug style and ligand-based drug style. Through it we are able to comprehend the drug receptor interaction. Structure primarily based Drug style includes binding Site identification, arrival and stocking, virtual screening, compound choice, lead optimization. Ligand Based Drug style includes quantitative structure activity relationship, medicine modelling and steps Followed as structure- primarily based drug style. As we are able to see CADD facilitate to acknowledge appropriate characteristics of a Drug and its compatibility to induce a straightforward hand in pre- clinical trials.
Prediction of Chronic Kidney Disease Using Machine Learning
Authors: Himani Hatwar  , Divya Chhaprwal  , Dvarkesh Rokade  , Santosh Kale
Published: February 2022

Chronic Kidney Disease is one of the most serious illnesses nowadays, and it is vital to have a good diagnosis as soon as possible. Machine learning has proven to be effective in medical therapy. The doctor can diagnose the ailment early with the use of machine learning classifier algorithms. This article has examined Chronic Kidney Disease prediction from this standpoint. The Chronic Kidney Disease dataset was obtained from the University of California at Irvine's repository. The artificial neural network, C5.0, Chi-square Automatic interaction detector, logistic regression, linear support vector machine with penalty L1 & with penalty L2, and random forest classifier techniques were used in this study. The dataset was also subjected to the significant feature selection technique. The results were computed for each classifier using I full features, (ii) correlation-based feature selection, (iii) Wrapper method feature selection, (iv) Least absolute shrinkage and selection operator regression, (v) synthetic minority over-sampling technique with least absolute shrinkage and selection operator regression selected features, and (vi) synthetic minority over-sampling technique with full features. The results show that in synthetic minority over-sampling technique with full features, LSVM with penalty L2 has the maximum accuracy of 98.86 percent. Along with precision, recall, F-measure, and area, accuracy, precision, recall, and area. The GINI coefficient and beneath the curve have been computed, and the results of various algorithms have been compared in the graph. After synthetic minority over-sampling technique with full features, the least absolute shrinkage and selection operator regression selected features with synthetic minority over-sampling approach produced the best results. Again, the linear support vector machine had the maximum accuracy of 98.46 percent in the synthetic minority over-sampling technique with the least absolute shrinkage and selection operator selected features. Along with machine learning models, a deep neural network was used on the same dataset, and the deep neural network was found to have the greatest accuracy of 99.6%.
Recent Developments in Chemical Mechanical Polishing (CMP) for Precision Manufacturing
Authors: Amey S. Kulkarni  , Ankur Gupta
Published: February 2022

Advanced developments and applications of Chemical Mechanical Planarization/Polishing (CMP) did by researchers in current decade were discussed in this article. Topics on which this article forms the basis are Abrasives and slurry developments, environment and safety conditions, manufacturing process improvements, modelling and simulations methods for CMP, optimization approaches, reduction of defects in CMP, aid of other manufacturing processes to improve manufacturing performance of CMP. This article expresses several approaches, methods etc. used by various researchers in past ten years from articles published by reputed publishers (IEEE, SPRINGER, ELSEVIER, SEMANTIC SCHOLAR etc.).
Robot Grip Robustness Prediction using a Hybrid Deep Learning Approach
Authors: Milan Bins Mathew
Published: February 2022

Humans have been using robots now for over a decade. With the latest developments in Electrical and Computer Engineering robots now can perform very critical tasks with high degrees of precision which was not possible in earlier times. Today robots perform various tasks such as industrial welding, space exploration, deep sea exploration, human surgery, bio-mechatronics etc. Now robot manufacturers have a wide variety of options to choose from while designing and developing their robots, from the mechanical parts to the software capabilities of the robot. One of the most common application of robots is to perform pick-and-place operations. The aim of this study is to predict the robustness in gripper robots using Deep Learning models so that the robot can be designed according to their robustness in safety critical environments. This is an important area as the robustness of the grip is a critical feature that must be ensured if the robot is to work with pick and place operations. The type of gripper to be used and its effectiveness determines the true value and efficiency of the robot. We have performed the analysis on shadow dataset obtained through Shadow Robot. The robot used in this study has a 3-finger gripper which is used to pick and place a ball. The proposed approach using an Artificial Neural Network (ANN) to extract features and Linear regression to predict the robustness factor of the grip. The model provides us an R-Squared score of 0.86 and an RMSE value of 18.12 which is sufficiently good and can help determine efficiently the robustness of the grip of the robot.
The Effect Of Predict-Observe-Explain (POE) Learning Model On Students' Science Process Skills Biology In MTs Aisyiyah Binjai
Authors: Ismayanti Ismayanti , Tanjung Indayana Febriani , Khairuddin Khairuddin
Published: February 2022

This study aims to determine the effect of the Predict-Observe-Explain (POE) learning model on science process skills in biology learning. This research was conducted at MTs Aisyiyah Binjai in the academic year 2020/2021, and this research was conducted at the end of May to June 2021. The type of research carried out was descriptive quantitative research. In sampling the researchers took two classes, namely the experimental class with 32 students using the Predict-Observe-Explain (POE) learning model and the control class with 32 students. The research method was carried out by preparing research instruments, namely observation sheets and student worksheets, validating instruments with 2 validators, namely North Sumatra State Islamic University lecturers and data collection was carried out by direct observation using observation sheet guidelines to see students' science process skills. The population in this study were all biology students of class VIII MTs Aisyiyah Binjai. Based on the research conducted, it shows the influence of students' science process skills using the Predict-Observe-Explain (POE) learning model. Judging from the results of data processing science process skills students in the experimental class with a percentage of 74% while in the control class with a percentage of only 41%. So that the KPS value of students in the experimental class is higher than the control class.
AI-Enabled Cybernetic Analytics of Security Models for Smart Serious Games-Based Mobile Operating Systems
Authors: Ali Abid , Jamil Faisal , Whangbo Taegkeun , Ahmad Shabir
Published: February 2022

Smart serious games are games which are primarily designed for a serious job such as education and training rather than entertainment. Mobile Phones are an essential enabler of smart serious games. Over the past few years, there has been an exponential growth in the security of the cyber-physical system of multiple operating systems. Security challenges have emerged from access scenarios in conventional operating systems. However, in Mobile Operating Systems, there is a lack of systematic study about mobile security measurement. Artificial Intelligence (AI) is one of the critical features which exists inside mobile operating systems. AI enhances the working of Mobile OS functionality by providing thinking on user behavior and extending the functionality. We explore some key security models for different mobile Operating System providers. In particular, the comparison of security policies implemented by multiple mobile operating system vendors. It's challenging to deal with and study the related data models and measurements for mobile operating system platforms. This paper collects, analyzes, and provides effective decisions about the existing research on multiple mobile operating systems. We consider the built-in security, Authentication, Data Protection, Device protection, Application Security, Device Wipe, Mobile Device Management, Cooperate Managed e-mail, Active Sync Support, Device Firewall, Security Certifications, and Virtualizations. AI supports all these features to help OS to extend its functionality for effective game management. We have focused on these components that clearly understand the Mobile operating system structure and support services. General, as well as specific features, are explored about the different platforms of the operating systems. The systematic research study is applied to these platforms to capture the response, and based on these responses, and we developed results based on the feedback and research responses. This comparison aims to make the right choice for mobile users to device the best mobile with a high-security Operating System installed for mobiles partaking serious games in cyber-physical environment.
An Automated Video Content Customization System using Eye Tracking and Artificial Intelligence
Authors: Lou Yuyang , Sun Yu
Published: February 2022

In the past few years, the internet and online social networks developed drastically, promoting the development of online learning programs. These programs provided opportunities for a digital learning experience that allows students to explore beyond what's taught in school. However, having a clear understanding of what topic might interest the user and motivate the user to further explore that topic is hard for both the user and the learning program. This paper proposes to create one centralized method of predicting what the user would be interested in and provide them with educational content recommendations. Our design builds upon the eyetracking techniques, which allows us to capture users’ eye movements, and object recognition achieved by machine learning, which allows us to examine the specific object that the users are looking at and provide data for the users’ interest analysis [3]. Our results show a success rate of 90% of analyzing what the user is truly looking at. We used our decision heuristic, etc.
Artificial Intelligence Systems for Teaching and Learning in Civil Engineering: Conceptual Framework
Authors: Coker L O Toriola , AYekini N , Alaka H , Ajimo A O
Published: February 2022

Artificial intelligence technology is based on design of machine or computer application that mimic human intelligent. Use of artificial intelligence in teaching and learning in civil engineering is a welcome development. This paper presents a conceptual framework of Artificial Intelligence Systems for Teaching, Learning, and administration of in Civil Engineering education. The proposed system is to be designed using the following tools: Extensible Markup Language (XML) to develop the GUI, Hypertext Pre-processor (PHP) for the web user interface (WUI), APACHE for middleware, MYSQL for database design, and UML will be used to visualize the design of the system. If the system is developed and implemented, it will go a long way to advance teaching and learning, and educational administration in civil engineering profession.
Trusting Machine Learning Algorithms in Predicting Malicious Nodes Attacks
Authors: Mahbooba Basim , Timilsina Mohan , Serrano Martin
Published: February 2022

Identifying network attacks is a very crucial task for Internet of things (IoT) security. The increasing amount of IoT devices is creating a massive amount of data and opening new security vulnerabilities that malicious users can exploit to gain access. Recently, the research community in IoT Security has been using a data- driven approach to detect anomaly, intrusion, and cyber-attacks. However, getting accurate IoT attack data is time-consuming and expensive. On the other hand, evaluating complex security systems requires costly and sophisticated modeling practices with expert security professionals. Thus, we have used simulated datasets to create different possible scenarios for IoT data labeled with malicious and non-malicious nodes. For each scenario, we tested off a shelf machine learning algorithm for malicious node detection. Experiments on the scenarios demonstrate the benefits of the simulated datasets to assess the performance of the ML algorithms.
How Did Humans, Animals and Plants Originate?
Authors: Yin Mei
Published: February 2022

With black hole explosion under incredibly high temperatures leading to cosmic information billions of years ago, all matters had been in gaseous phase. With temperature dropping, under atomic attractive forces, adjacent atoms which made up gases attracted each other and formed a variety of big, small or tiny gaseous lumps. With the temperature persistently dropping, the tiny gaseous lump became colder and contracted and got smaller and turned into one in liquid state and subsequently in solid state according to the principle of expanding when heated and contracting when cooled in general cases. Gradually it developed and formed a human- or animal-like fetus or a plant-like seed. If it had the same compositions as a human, cow or sunflower, the human, the cow or the sunflower formed. Similar cases happened to other humans, animals and plants. Humans neither evolved from apes nor shared a common ancestor with apes.
An assessment of dietary diversity and nutrition knowledge of student nurses at the KwaZulu-Natal College of Nursing
Authors:   , Wirth Janet Dorothy
Published: March 2022

South Africa has a high prevalence of obesity, and many people live with diseases where dietary adaptations are part of the management of the disease. Nurses are important in the facilitation of people obtaining dietary advice. While nutrition education is part of the nursing curriculum, student nurses’ knowledge of nutrition was not known, nor was their dietary intake and nutritional health status. The purpose of the study was to assess the nutrition knowledge of students at a nursing college, and to assess their dietary diversity. A quantitative study was used, with random sampling chosen for selection of campuses and convenience sampling for student group selection. Students of the KwaZulu-Natal College of Nursing were invited to complete a General Nutrition Knowledge Questionnaire. A Food Frequency Questionnaire was completed to assess dietary diversity, and respondents’ anthropometric measurements were recorded to assess Body Mass Index and Waist to Height Ratio. The results showed that a significant percentage of student nurses were overweight or obese. While students had a satisfactory knowledge of dietary recommendations and sources of different nutrients, their ability to make correct food choices, as well as their knowledge of diet-disease relationships was poor. They displayed good dietary diversity in their food intake. There were no statistically significant correlations between the students’ Body Mass Index and their knowledge, which assumes that the individual’s knowledge of nutrition does not directly influence their own food intake. It is recommended that aspects of the content in the nutrition curriculum be emphasised during the training of nurses in order to increase nutrition awareness in areas where knowledge was found to be lacking.
An investigation into normative values for the Functional Movement Screen?(FMS?) and its association to injury in female premier league hockey players in KwaZulu-Natal
Authors:   , Jooste Anneke
Published: March 2022

Background The Functional Movement Screen (FMSTM) is a pre-participation screen consisting of seven tests that rate a player’s functional movement. The screen may be used as an indicator for injury susceptibility in sports people. This may be implemented for preventative measures and improving or sustaining performance in sport. Objectives This research aimed to identify normative values on the FMSTM for female premier league hockey players and assess the association between FMSTM scores and incidence of seasonal injuries. Secondary to this, the research also undertook to assess dependence of the FMSTM on other risk factors identified in the study such as age, number of years playing hockey, height, weight, BMI and position. These risk measures were also tested for association to injury susceptibility. Method The research evaluated the FMSTM score in female premier league hockey players in KwaZulu-Natal prior to the commencement of the competitive season and then tracked the incidence, frequency and distribution of injuries that were sustained during the season. All nine teams in the KwaZulu-Natal female premier hockey league were approached and the players voluntarily participated provided that they fitted the inclusion criteria. In total 74 players between the ages of 18 and 35 were assessed. SPSS version 20 was used in the data analysis to test for statistical significance of the results. Results and conclusions The research sample revealed a mean FMSTM score of 14.39 with a standard deviation of 2.4. The difference in average FMSTM score between the 18 players who sustained non-contact injuries during the course of the season and the 56 players who did not was shown to not be statistically significant at a 95% confidence level. Therefore, this research shows that no association can be made between a low score on the Functional Movement ScreenTM and injury susceptibility. The FMSTM score was shown to be an independent metric when compared to the other injury risk measures identified in the study and the other risk measures were also found to not reliably indicate injury susceptibility. Having said this, the association of weight, FMSTM and BMI with injury susceptibility warrants further investigation as these measures indicated a degree of association.
Assessment of the use of the new maternity case record in improving the quality of ante-natal care in eThekwini District, KwaZulu-Natal
Authors:   , Cele Reginah Jabulisile
Published: March 2022

Brief background to the study The national guidelines for maternity care in South Africa recommend that a standardised maternity case record be used by all facilities at all levels of care in order to improve the quality of care for pregnant women. According to the National Department of Health, this will facilitate continuity and quality of care for women during pregnancy, labour and post-partum. Aim of the study The aim of the study was to assess whether the implementation of the new maternity case record has improved the quality of care for pregnant women. Methodology An exploratory, descriptive study using both quantitative and qualitative design was used to conduct the study. Data was collected through a retrospective record review using a checklist for the quantitative strand, and from midwives using unstructured interviews for the qualitative strand. The quantitative data set was analysed using the Statistical Package for the Social Sciences version 21.0 and the qualitative strand was analysed using the Tesch’s method of data analysis. Results The results of the record review revealed that although the recording was done fairly well, there were a number of activities and interventions that were recorded poorly or not recorded at all in some primary health care clinic. The midwives verbalised that many mistakes and mismanagement of ante-natal care clients emanated from the structure and the design of the new maternity case record. Recommendations Recommendations include the following: communication of policies and protocols to the midwives should be done timeously, provision of in-service education and/or updates on new developments, strengthening of supportive supervision, the Nursing colleges be kept up-to-date with new developments in nursing practice and that a broader study involving other districts and provinces be conducted.
Evaluation of the use of guided reflective journals during clinical learning and practice by undergraduate nursing students at the Durban University of Technology
Authors:   , Mahlanze Hazel Thokozani
Published: March 2022

Background The Council for Higher Education and the South African Nursing Council accredit institutions with learning and assessment practices which aim to develop and prepare graduates to be critical thinkers. The undergraduate nursing programme at the Durban University of Technology introduced the writing of reflective journals by their students in 2011. Students submitted journals of poor quality which lacked reflection. Aim of the study The purpose of this study was to evaluate the use of guided reflective journals by assessing the levels of reflection of the undergraduate nursing students during clinical learning and practice. Methodology An exploratory sequential mixed methods design, using quantitative and qualitative paradigm, was used for this study. A purposive sample of 40 participants was used to collect data. A perceptions questionnaire was administered to the 40 participants to determine their perceptions on how they experienced writing of the reflective journals. Content analysis was used to analyse the written content of the reflective journals. Descriptive statistics such a Chi-square goodness of fit and Wilcoxon Signed Ranks test were used determine levels of reflections and the differences in the first and second journals. Lincoln and Guba’s 1985 criteria for trustworthiness were applied to the study. Results Analysis of the journals revealed lower levels of reflection in the first reflective journal compared to improved levels in the second journal. Furthermore, the participants generally expressed writing of reflective journals as a valuable tool in professional, personal development as well as clinical learning. Levels of reflection and development of reflective practice will be greatly enhanced if all involved in nurse education will actively participate in encouraging writing of reflective journals by student nurses.
Ecological and geochemical assessment of the content of chemical elements and features of their spatial distribution in Fe nodules of soils in the Middle Cis-Urals
Authors:   Perm State Agro-Technological University, Gorokhova Svetlana , Vasilev Andrey
Published: February 2022

This work is about the ecological and geochemical assessment of the elemental chemical composition of soil nodules in the taiga zone of the Middle Cis-Urals. The features of the spatial distribution of chemical elements in concretions of Umbric Albeluvisols Abruptic, Luvic Stagnosols Dystric, and Haplic Fluvisols Oxyaquic are characterized for the first time using atomic absorption spectrometry and scanning electron microscopy with energy-dispersive analysis. A concentric ring structure of nodules with alternating zones rich in Fe and Mn has been revealed. Nodules act as geochemical barriers and accumulate not only iron and manganese, but also Cu, Ni, Co, Zn, and Pb. Keywords: ALBELUVISOLS, STAGNOSOLS, FLUVISOLS, ORTSHTEIN, RORENSTEIN, GEOCHEMISTRY CONSTANTS, ATOMIC ABSORPTION SPECTROMETRY, SEM/EDS, FE AND MN DISTRIBUTION, RING MICROSTRUCTURE
Analysis of the Clinical Factors Affecting the Quality of Life in Children with Hemophilia A
Authors: Wardhani Adwina Nurlita Kusuma , Ugrasena Dewa Gede , Andarsini Mia Ratwita , Larasati Maria Christina Shanty , Cahyadi Andi , Suryawan Ahmad , Prasetyo Risky Vitria , Setiawati Yunias , Khaerani Putri
Published: February 2022

Background: Utilization of a specified questionnaire to measure the Health-related quality of life (HRQoL) in children with hemophilia is unusual especially in a country with resources limited settings. The objective of this study is to analyze the quality of life (QoL) of children with hemophilia A and the clinical factors that affect them.
Methods: A cross-sectional study was conducted in September 2021. The participants were children with hemophilia A who were registered at the Indonesian Hemophilia Society Association (IHSA) in Surabaya. Inpatients, children with cognitive impairment, mental health disorder, aged 8 to 16 years old and cannot read, and declined to participate are not included. The questionnaires are using Hemophilia-Specific Quality of Life (Haemo-QoL) which have been validated in Bahasa Indonesia. HRQoL was assessed for 3 age groups (I: 4 to 7; II: 8 to 12; and III: 13 to 16 years).
Results: All participants (21 children) were male with a median age of 148 months. More than half (52.4%) of the children had mild hemophilia, followed by moderate hemophilia. The mean total Haemo-QoL score was 38.57 (+9.52). The youngest age group are experienced the highest disturbance in the family dimension, followed by the sports school dimension; children in the second and third age group were impaired in friends and sports school dimension. There was no significant correlation between clinical factors studied and the QoL of children with hemophilia A.
Conclusion: The QoL of the youngest age groups must be prioritized due to susceptibility to the family dimension. Appropriate and prompt treatment plays a major role because the treatment of this disease does not depend on the severity of the patient’s clinical factors.
VCAM-1 Values in Obese Adolescents with Dyslipidemia and Insulin Resistance
Authors: Nova Suhasta , Irawan Roedi , Widjaja Nur Aisiyah , Irwanto Irwanto
Published: February 2022

Background: The incidence of obesity in adolescents in the world is increasing. Obesity can lead to atherosclerosis, which is initially accompanied by endothelial dysfunction.
Methods: This study cros sectional study conducted from Februari to September 2021 in Surabaya, indonesia. VCAM-1 was examined in the Institute Tropical Diseases (ITD) laboratory using ELISA methods.
Result: One hundred and sixteen children are included in this study, consisting of 107 obese children and 9 non-obese children. The VCAM-1 values in obese adolescents increased 2.4x compared to those in non-obese adolescents (p-value 0.001). The VCAM-1 values in obese adolescents without dyslipidemia nor insulin resistance increased 2.4x (p-value 0.001), in obese adolescents who had dyslipidemia it increased 2.2x (p-value 0.001), in obese adolescents who had insulin resistance it increased 1.8x (p-value 0.007), and in obese adolescents who had dyslipidemia and insulin resistance it increased 2.5x (p-value 0.007) compared to those in non-obese adolescents without dyslipidemia nor insulin resistance. There was no significant difference in the VCAM-1 values neither in obese adolescents who had dyslipidemia (p-value 0.377), in obese adolescents who had insulin resistance (p-value 0.174), nor obese adolescents who had dyslipidemia and insulin resistance (p-value 0.769) compared to those in obese adolescents who had no dyslipidemia nor insulin resistance.
Diagnosis and Management of 46 XX Disorders of Sex Development (DSD) Aromatase Deficiency in Resource-Restricted Setting
Authors: Sitepu Jefri Adi Kam , Wibowo Marjono Dwi
Published: February 2022

A 12 years old children with genital ambiguity was reported. Late diagnosed was occurred due to complexity of the disease. Initial assessment in newborn baby is importance for early diagnosis and prompt treatment for disorder of sex development with genital ambiguity. Experienced multidisciplinary team is required for optimal care children with DSD. Further monitoring and continuous follow up are needed to evaluate response of hormonal replacement therapy, surgical options, potential for fertility, and psychosocial development to improve patient QoL.
Profiles and Clinical Outcomes of Perforated Peptic Ulcer with Boey Score 3 Treated with External Drainage in Indonesia
Authors: Efendi Rachman , Septarendra Denny
Published: February 2022

The treatment of peptic ulcers has changed substantially, and the rate of elective surgery for gastroduodenal peptic ulcers has fallen significantly; as a result, the rate of emergency surgery for perforated peptic ulcers has slightly increased. The Boey score is one of the most widely used prognostic scoring systems for predicting death in peptic ulcer perforation patients. The Boey scoring system has a positive connection with mortality risk. Patients with Boey Score 3 are patients who meet the high-risk criteria and have high morbidity and mortality rates. Conservative therapy can be utilized as an alternative to surgery in some cases with perforated gastroduodenal ulcers. In this study, we presented a clinical case of perforated peptic ulcer patient with Boey score 3 treated with external drainage for the conservative treatment.
Effect of Omega-3 On Orthodontic Tooth Movement: A Systematic Review
Authors: Nurhasanah Siti Hardiyanti , Sari Gadis Meinar , Prameswari Noengki
Published: February 2022

Orthodontic movement is a continuous and balanced process characterized by resorption and apposition of bone in areas of pressure and tension after mechanical strength forces are applied. The purpose of this systematic review was to determine the effect of omega-3 administration on orthodontic tooth movement from various studies that have been carried out previously. Search articles online using PubMed, ProQuest, Scopus, Ebscohost, and Google Scholar between 1995-2021. The keywords used were (Orthodontic tooth movement OR Orthodontic movement AND bone remodelling OR Alveolar bone remodelling OR Alveolar remodelling AND Omega 3 OR Fatty acids OR EPA DHA). A total of 530 articles were obtained and then screened using titles, abstracts, and can access full text there are 44 articles. Then by using inclusion and exclusion criteria, three full-text journals were obtained and compiled using PRISMA. These studies show that omega-3 administration affects orthodontic tooth movement. Omega 3 can slow down the movement of orthodontic teeth so that it can consider as a method of preventing relapse by giving omega-3 at the end of orthodontic treatment.
Complication of Hollow Organ Perforation after Radical Nephrectomy in Wilms Tumor: A Case Report
Authors: Fahada Helmy , Kusumawidagdo Fransiska
Published: February 2022

The most frequent kidney cancer in children is Wilms tumor, often known as nephroblastoma. The prevalence is low and only representing for approximately 7% of all childhood cancers. The most standard treatment for this tumor is surgery. Complications from surgical care occurred in patients with Wilms tumor who had a radical nephrectomy. Intestinal blockage, hemorrhage, infection, and vascular injury are the most common surgical consequences. The purpose of this case report is to describe the incidence of perforation of hollow organs after radical nephrectomy in the case of Wilms tumor in a child aged 2 years and 6 months after neoadjuvant chemotherapy, who later developed generalized peritonitis due to ileal anastomoses leakage.
The Effect of Collagen-Chitosan-Sodium Hyaluronate Implantation Composite on Inflammation Reaction (Flare) In New Zealand Rabbit Corneal Stroma
Authors: Akmalin Diana , Prastyani Reni , Widiyanti Prihartini
Published: February 2022

Corneal transplantation is a solution in treating visual disturbances due to corneal opacities, but this procedure is said to be limited. Various efforts have been made in the development of alternative therapies, one of which is by using composite biomaterials. For this reason, this study aimed to analyze the effect of the collagen-chitosan-sodium hyaluronate composite on the inflammatory reaction (flare) in the corneal stromal injury of New Zealand rabbits. The method used was thirty adult male New Zealand rabbits which were divided into three groups. The first group (negative control) was not treated, the second group (positive control) was subjected to intrastromal injuries by making a stromal pocket with the help of a crescent knife, and the third group had a collagen-chitosan-sodium hyaluronate biomaterial implanted in the stromal pocket. The results of this study showed that there were significant differences in inflammatory reactions (flares) in the collagen-chitosan-sodium hyaluronate composite implantation group with the control and positive control groups (p = 0.001, >0.01). Therefore, it can be concluded that the inflammatory reaction (flare) in the implanted group was higher than the control group, this could occur due to the short observation period so that the biomaterial was not completely absorbed.
Control de inventario y rentabilidad en una empresa ferretera de Manantay - Perú
Authors: Pizzan-Tomanguillo Nieves del Pilar , Rosales Bardalez Carlos Daniel , Cris Charly Ceron Shapiama
Published: February 2022

El presente informe tuvo como objetivo general: Determinar el nivel de relación entre control de inventario y rentabilidad en la empresa “El mundo de los Repuestos JR E.I.R.L”., periodo 2018-2019. En cuanto a la estructura metodológica del estudio fueron: enfoque cuantitativo de tipo básico, nivel descriptivo correlacional, diseño no experimental de corte longitudinal, la muestra determinada por 48 estados financieros (24 estados de situación financiera y 24 estados de resultados) mensuales de la empresa, la técnica empleada fue el análisis documental. Se llegó a la conclusión que existe relación entre la rotación de inventario y la rentabilidad sobre activos, porque se constató un p-valor =0.027<0.05, así también, existe relación entre la rotación de inventario y la rentabilidad neta con un p-valor =0.048<0.05, por lo contrario, no existe relación entre la rotación de inventario y rentabilidad sobre el capital. Por consiguiente, existe relación entre plazo medio de existencia y la rentabilidad neta, porque se constató un p-valor =0.00<0.05, además existe relación entre plazo medio de existencia y rentabilidad sobre activo, porque se constató un p-valor =0.005<0.05, finalmente, existe relación entre plazo medio de existencia y la rentabilidad sobre el capital, porque se constató un p-valor =0.008<0.05.
Análisis de la comunicación comunitaria, procesos y elementos psicológicos: caso ciudadela Las Piñas de la Ciudad Milagro - Ecuador
Authors: Viejó Mora Israel , Cabezas Pinta Víctor , Pincay Aguilar Iván , Donoso Reinoso Hugo , Mendoza Carrera Jefferson
Published: February 2022

La investigación tiene como objetivo analizar los procesos y elementos psicológicos de comunicación que se generan en la ciudadela Las Piñas de la ciudad de Milagro, para lo cual se ha aplicado un diseño descriptivo con enfoque cuali-cuantitativo por medio de entrevista a profundidad y encuestas, para ello se seleccionó una muestra de 6 líderes comunitarios y 323 moradores. Los resultados demostraron un desconocimiento acerca de la participación comunitaria por parte de los líderes, así como de los moradores, evidenciado más bien actividades coordinadas de cooperación como reuniones, mingas y brigadas para gestionar necesidades puntuales de la comunidad. En cuanto a los procesos de comunicación estos se encuentran limitados para con las autoridades municipales y de forma interna en la comunidad las acciones son personales o por medio de WhatsApp. Además, con respecto a los elementos psicológicos, existe un total desconocimiento de las normativas legales por parte de la comunidad producto de la percepción desfavorable lo que declina las actitudes y valores de la ciudadanía frente a estos fenómenos. Todo ello dificulta un adecuado movimiento participativo.
Do modelo tradicional ao ambiente virtual de ensino na rede pública e privada do estado de São Paulo
Authors: Moura Silva Alex , Alexandre da Silva Francisco
Published: February 2022

Em consequência a pandemia causada pelo novo coronavírus, no Brasil e no mundo a educação básica passou por diversas transformações. O objetivo deste artigo é refletir sobre os impactos da pandemia causada pela COVID-19 e analisar os desafios da práxis docente da rede pública (Secretaria de Educação do Estado de São Paulo – SEDUC/SP, Secretaria Municipal de Educação de São Bernardo do Campo - SME/SBC) e particular do município de São Bernardo do Campo.   De acordo com os procedimentos técnicos, o presente artigo caracteriza-se como uma revisão bibliográfica e estudo de caso, visto que, foram vinte artigos lidos, sendo utilizados doze artigos e, consequentemente, sete artigos descartados.  Aplicou-se um questionário aos 125 docentes da educação básica da rede pública e privada do estado de São Paulo. Os resultados da pesquisa foram analisados através de tabela sobre o perfil do corpo docente e as expectativas dos mesmos em relação à formação de professores e o ensino remoto. Por fim, embora as Tecnologias de Informação e Comunicação (TICs) são presentes no século XXI, existem diversos fatores que acabam influenciando na relação práxis pedagógicas e TICs.
FORMULASI DAN PENENTUAN NILAI SUN PROTECTION FACTOR (SPF) SEDIAAN KRIM TABIR SURYA EKSTRAK ETANOL BEKATUL PADI BERAS MERAH (Oryza sativa L)
Authors: Suhery Wira Noviana , Novita Dewi  , Rahayu Utami  , Mustika Furi  , Melzi Octaviani
Published: February 2022

Penelitian mengenai formulasi sediaan krim tabir surya dari ekstrak etanol bekatul padi beras merah (Oryza sativa L) dan penentuan nilai SPF secara in vitro menggunakan spektofotometer UV telah dilakukan. Ekstrak etanol bekatul padi beras merah telah terbukti mempunyai aktivitas antioksidan. Penentuan nilai SPF perlu dilakukan untuk mengetahui kemampuan ekstrak etanol bekatul padi beras merah dalam melindungi kulit dari radiasi sinar UV.  Ekstrak etanol bekatul padi beras merah diformulasi dalam bentuk sediaan krim tipe m/a yang terdiri dari F1 dan F2 menggunakan konsentrasi ekstrak masing-masing 5% dan 10%. Berdasarkan penelitian yang dilakukan diperoleh hasil F2 memiliki nilai SPF yang lebih tinggi yaitu 13,098 dibandingkan F1 yaitu 11,861. Berdasarkan nilai SPF yang dihasilkan dari formula dapat disimpulkan bahwa sediaan krim tabir surya ekstrak etanol bekatul padi beras merah dapat melindungi kulit dari radiasi sinar UV secara maksimal selama 110-130 menit.
UJI TOKSISITAS AKUT EKSTRAK ETANOL DAUN TUMBUHAN AKAR KAIK-KAIK (Uncaria cordata (Lour) Merr) TERHADAP MENCIT PUTIH JANTAN (Mus musculus L)
Authors: Djohari Meiriza , Noveri Rahmawati  , Nur Indah Melati
Published: February 2022

Telah dilakukan penelitian tentang uji toksisitas akut ekstrak etanol daun tumbuhan akar kaik-kaik (Uncaria cordata (Lour) Merr) pada mencit putih (Mus musculus L.) jantan. Penelitian ini bertujuan untuk mengetahui efek toksisitas akut dan tertunda dari ekstrak etanol daun tumbuhan akar kaik-kaik (Uncaria cordata (Lour) Merr) melalui penentuan nilai LD50. Hewan percobaan dibagi menjadi 4 kelompok, yaitu kelompok kontrol negatif (NaCMC), dan kelompok ekstrak etanol daun tumbuhan akar kaik-kaik dengan dosis 200, 1000, dan 5000 mg/KgBB. Hasil penelitian menunjukkan bahwa nilai LD50 >5000 mg/kg BB dan termasuk kedalam kategori  praktis tidak  toksik. Pada pengamatan tidak terjadi adanya tremor, kejang, salivasi, diare, letargi, lemah, tidur, dan koma pada setiap hewanpercobaan.
PENGETAHUAN MASYARAKAT TENTANG APLIKASI CEK-KLIK BPOM PADA OBAT TRADISIONAL DI KUBANG JAYA KAMPAR
Authors: DEWI Ratna Sari Dewi , Muhammad Dani Jabbar
Published: February 2022

Publicwarning yang telah dikeluarkan BPOM tahun 2017 bahwa didapati 39 obat tradisional positif mengandung BKO dan pada tahun 2018 didapati 7 obat tradisonal yang mengandung BKO. Salah satu upaya BPOM dalam pengawasan serta perlindungan konsumen terhadap peredaran obat tradisional tidak berizin yaitu dengan menghadirkan aplikasi CEK KLIK pada android. Penelitian ini bertujuan untuk mengetahui tingkat pengetahuan masyarakat tentang aplikasi CEK KLIK. Penelitian ini merupakan penelitian observasional dengan rancangan deskriptif dengan metode pengumpulan data secara concurrent melalui pengisian kuesioner online. Populasi penelitian yaitu masyarakat Kubang Jaya Kampar berjumlah 37031. Teknik pengambilan sampel secara non probability sampling dengan metode purposive sampling. Jumlah sampel sebanyak 160 responden yang memenuhi kriteria inklusi. Hasil penelitian menunjukkan bahwa masyarakat yang memiliki pengetahuan baik sebanyak 24.4%, pengetahuan cukup sebanyak 47.5%, dan pengetahuan kurang sebanyak 28,1% . Dapat disimpulkan bahwa sebagian besar masyarakat masih belum mengetahui tentang aplikasi CEK KLIK tersebut.
ANALISIS KETERKAITAN SIKAP DAN PENGETAHUAN PASIEN HIPERTENSI TERHADAP KEPATUHAN PENGGUNAAN OBAT ANTI HIPERTENSI DI RUMAH SAKIT ISLAM PURWODADI
Authors: Ratna Ratna Wulandari , Delia Paramita  , Eleonora Maryeta Toyo
Published: February 2022

Abstrak

Hipertensi merupakan penyakit yang memiliki angka prevalensi yang tinggi. Hipertensi dapat distabilkan dengan melakukan pola hidup yang sehat dan menggunakan obat anti hipertensi. Penggunaan obat antihipertensi diperlukan kepatuhan agar hipertensi dapat terkontrol. Kepatuhan pasien dalam melaksanakan pengobatan harus dipertahankan dalam jangka waktu yang lama, oleh sebab itu pasien harus memiliki pengetahuan yang baik dan sikap yang positif terhadap hipertensi. Tujuan penelitian ini adalah untuk mengetahui hubungan sikap dan pengetahuan pasien hipertensi terhadap kepatuhan peggunaan obat anti hipertensidi Rumah Sakit Islam Purwodadi. Penelitian ini menggunakan metode sensus dengan rancangan Cross Sectional. Desain ini digunakan untuk meneliti suatu kejadian dalam waktu yang bersamaan atau dalam sekali waktu. Teknik sampling dalam penelitian ini menggunakan metode sensus. Instrumen penelitian yang digunakan berupa kuesioner. Analisis data yang digunakan adalah analisis univariat dan bivariat. Dari analisis univariat didapatkan hasil 65% responden memiliki sikap yang baik, 70% responden memiliki tingkat pengetahuan yang baik, serta 55% responden memiliki kepatuhan minum obat antihipertesi yang tinggi. Pada analisis bivariat dengan uji statistik Chi Squareα < 0,05 didapatkan hasil bahwa ada hubungan antara sikap dan kepatuhan minum obat antihipertensi (p value= 0,005), dan terdapat hubungan antara tingkat pengetahuan dan kepatuhan minum obat antihipertensi di Rumah Sakit Islam Purwodadi (p value = 0,021).
Optimasi Formula Stick Balm Minyak Atsiri Daun Sereh (Cymbopogon citratus)
Authors: I Komang Ary Werdhi Widnyana  , Windah Anugrah Subaidah  , Nisa Isneni Hanifa
Published: February 2022

Kandungan pada minyak atsiri daun sereh (Cymbopogon citratus) memiliki efek sebagai neurobehavioral, sehingga minyak atsiri daun sereh dapat bermanfaat sebagai aromaterapi. Untuk meningkatkan kenyamanan pengguna dan kemudahan dalam pengaplikasiannya, diperlukan inovasi baru sediaan aromaterapi berupa sediaan stick balm. Penelitian ini bertujuan untuk menentukan formula optimum serta sifat fisik sediaan stick balm minyak atsiri daun sereh dengan variasi zat tambahan cera alba dan lanolin. Delapan rancangan formula stick balm ditentukan menggunakan metode SLD (Simplex Lattice Design), dengan aplikasi Design Expert 11, dan dibuat menggunakan metode peleburan. Stick balm diuji sifat fisik meliputi uji pH, titik leleh, dan daya lekat. Respon uji sifat fisik diolah untuk memperoleh formula optimum. Sediaan optimum stick balm diuji sifat fisik, organoleptis, dan homogenitas. Hasil uji sifat fisik sediaan optimum diverifikasi dengan metode one sample t-test menggunakan aplikasi SPSS. Hasil optimasi formula diperoleh konsentrasi lanolin 5,310% dan cera alba 11,690%. Sediaan optimum stick balm berwarna kuning cerah, bau khas minyak sereh, konsistensi semi padat, bahan tercampur homogen, nilai pH 5,63±0,06, titik leleh 44,5±0,5oC, dan daya lekat 2,437±0,106 detik, sehingga sediaan optimum stick balm memenuhi syarat fisik. Sifat fisik sediaan optimum tidak berbeda signifikan dengan prediksi pada aplikasi Design Expert 11.
KADAR FENOLIK DAN FLAVONOID TOTAL SERTA AKTIVITAS ANTIOKSIDAN DARI EKSTRAK METANOL AKAR, DAUN DAN BUNGA SIMPUR AIR (Dillenia suffroticosa Griff. Ex Hook)
Authors: Utami Rahayu Utami , Ginta Rio Maranti  , Mustika Furi  , Melzi Octaviani  , Septi Muharni  , Fina Aryani  , Husnawati  , Wira Noviana Suhery  , Musyirna Rahmah Nst  , Fadhli Haiyul , Emma Susanti  , Emrizal
Published: February 2022

Simpur air merupakan salah satu tumbuhan yang secara tradisional banyak digunakan dalam pengobatan berbagai macam penyakit. Beberapa penelitian tentang kandungan kimia dan aktivitas biologis dari tumbuhan ini telah dilaporkan. Namun, belum ditemukan penelitian dari kandungan kimia dan aktivitas antioksidan ekstrak simpur air yang berasal dari daerah Riau. Penelitian ini bertujuan untuk mengetahui kandungan fenolik dan flavonoid total serta aktivitas antioksidan dari ekstrak metanol akar, daun dan bunga dari simpur air. Penentuan kandungan fenolik dan flavonoid total dilakukan dengan metoda spektrofotometri menggunakan reagen masing-masingnya adalah Folin Ciocalteu dan AlCl3, sedangkan uji aktivitas antioksidan dilakukan dengan metoda DPPH. Berdasarkan hasil penelitian diketahui bahwa ekstrak metanol akarnya memberikan nilai kandungan fenolik total, flavonoid total dan aktivitas antioksidan yang paling tinggi dibandingkan ekstrak metanol daun dan bunganya. Nilai kandungan fenolik totalnya sebesar 428,131 GAE/mg ekstrak, nilai flavonoid totalnya adalah 766,164 QE/mg ekstrak dan nilai IC50 adalah sebesar 3,852 µg/ml.
O DESENVOLVIMENTO INFANTIL
Authors: Tancredi Cleunice Carvalho da Rosa , Silva Jóici Pinheiro da , Silva Kely Cristina da , Schnorr Marilene Maria , Santos Mirela Nogueira dos , Santos Raquel de Almeida , Lima Rosangela Kovalski da Cruz
Published: February 2022

Este artigo discute o desenvolvimento da linguagem na infância, bem como os aspectos cognitivos, físicos, motores e emocionais, todos de  importância primordial para o surgimento da linguagem. Os objetivos do mesmo são compreender o desenvolvimento infantil como um longo processo  no qual existem vários símbolos e identificar e compreender como a aquisição da linguagem é estimulada, em cada fase do desenvolvimento infantil, com a participação de diferentes componentes. como a família, a escola, o ambiente externo e interno e o contato da criança com a sociedade como um todo. Aos 5 anos, as crianças já dominam os sistemas sonoros e gramaticais da linguagem e adquiriram um vocabulário de milhares de palavras. Este artigo descreve as principais etapas do desenvolvimento da linguagem durante os primeiros anos de vida da criança.