bluuebunny/crossref_metadata_2025 huggingface dataset:
The Infusion of Folk Catholicism to Tambal Binisaya as an Indigenous Healing System in Iligan City
Authors:   Mindanao State University-Iligan Institute of Technology, Iligan City, Philippines, Crisol Lourd Greggory , Oledan Efren Jone ,   Mindanao State University Marawi Campus, Marawi City, Philippines
Published: June 2022

For generations, folk medicines have been used to cure various diseases with supernatural and naturalistic causations. With ethnographic descriptive design, mananambals, Tambal Binisaya vendors, and loyal patrons served as key informants in this qualitative study. In obtaining the data, observations, field notes, and interviews were the main instruments used to investigate inculturation, which is the underlying phenomenon behind the folk Catholicism evident in Tambal Binisaya. As such, it was revealed that there are strong pieces of evidence of pre-Christian practices in Tambal Binisaya, such as belief in abyans, balance in natural elements in the body, and even animism, which are somehow divergent from Catholic beliefs that put a premium on God and the total healing of the mind, body, and spirit. Despite these differences, Tambal Binisaya somehow integrated these aspects of the two systems into a hybrid healing practice. The indigenous have indeed been married to Catholicism in Tambal Binisaya.
The Community of Inquiry Instructional Strategies Impact on Student Satisfaction on Remote Learning
Authors:   University of the Philippines Cebu, Cebu City, Philippines, Chaves Mary Gretchen
Published: June 2022

The COVID-19 restrictions compelled institutions worldwide to transition into the remote teaching-learning modality abruptly. Studies evaluating the effectiveness of remote teaching and learning strategies are scant. With the recent shift to this new learning mode, little is known about the fulfillment of learning outcomes and student satisfaction. This research examines the impact of the teaching-learning course design and instructional strategies as implemented by this faculty researcher last school year 2020-2021. It intends to provide practical guidance for teachers aiming to evaluate the effectiveness of their remote teaching/strategies. The research is both quantitative (causal) and qualitative design. A total of 104 management students from a Philippine state university participated in an online survey. The quantitative investigation assessed the influence of the independent variables – the Community of Inquiry (CoI) presence strategies, course design, and instructional strategies on students’ perceived learning and satisfaction, utilizing the CoI framework and adopting scales from online teaching.
Developmental Coordination Disorder (DCD): Relevance for clinical psychologists in Europe
Authors: Meachon Emily J. , Zemp Martina , Alpers Georg W.
Published: June 2022

Background

Developmental Coordination Disorder (DCD) is a common neurodevelopmental disorder primarily characterized by fine and gross motor coordination difficulties. Yet, many aspects remain unclear regarding the clinical presentation of secondary symptoms and their implications for Clinical Psychology. Therefore, the purpose of this review is to provide an update about the current understanding of DCD for clinical psychologists and psychotherapists across Europe, particularly based on new insights stemming from the last decade of research.

Method

We provide a narrative review of articles published in the last decade on the topic of DCD, and relevant aspects to clinical psychologist, including lesser known aspects of DCD (e.g., executive functions, psychological consequences, and adult DCD).

Results

DCD is a highly prevalent, disruptive, and complex disorder, which should be investigated further in many areas (e.g., co-occurrence to ADHD). Existing evidence points toward a key role of executive functioning difficulties at all ages. Most patients report secondary psychological problems, but little headway has been made in examining the effectiveness of psychotherapy for DCD.

Conclusions

Insights and remaining research gaps are discussed. It is critical for psychologists and clinical researchers to raise awareness for DCD, take note of the growing literature, and foster continued interdisciplinary approaches to research and treatment of DCD.
Social media use and mental health in young adults of Greece: A cross-sectional study
Authors: Leimonis Epameinondas , Koutra Katerina
Published: June 2022

Background

Social media use has vastly increased during the past few years, especially among young adults. Studies examining the relationship of social media use with mental health have yielded mixed findings. Additionally, such studies are extremely limited in Greece. The present study aimed to investigate the association between social media use, depressive symptoms and self-esteem among Greek young adults.

Method

A total of 654 individuals (50.5% male) aged 18-30 years (Μ = 23.62, SD = 2.71) completed self-reported questionnaires regarding social media use, depressive symptoms and self-esteem.

Results

Increased daily use of YouTube (more than five hours) showed a significant association with higher depressive symptomatology, b = 2.99, 95% CI [.78, 5.20], p = .008, while daily use of Facebook between two and five hours was related to significantly higher self-esteem, b = 1.61, 95% CI [.78, 2.44], p < .001, after adjusting for participants’ gender, age, educational level and employment status. The association of increased daily use of YouTube with depressive symptoms was more pronounced in males than in females. Moreover, self-reported active use of Facebook and Instagram were linked with significantly lower depressive symptoms and higher self-esteem compared to passive involvement.

Conclusion

The results suggest that social media use is closely related to self-esteem and depressive symptomatology in young adults. These findings may contribute to a deeper clinical understanding of the association between electronic social networking and mental health.
THE FUTURE OF E-ARBITRATION IN MALAYSIA: PRELIMINARY ANALYSIS ON THE LEGITIMACY OF E-ARBITRAL AGREEMENT AND PROCEDURES
Authors: Labanieh Mohamad Fateh , Hussain Mohammad Azam , Mahdzir Nazli
Published: June 2022

Using electronic technology in the dispute resolution industry has been encouraged globally. Electronic arbitration (e-arbitration) is one of the main online dispute resolution mechanisms, and it should be implemented in Malaysia because of its significant advantages. Unfortunately, the future of e-arbitration in Malaysia is still hazy. Therefore, it is important to examine whether existing Malaysian laws are sufficient to legalise the e-arbitral agreement and e-arbitral proceedings. This article is based on a research carried out for a doctoral degree. Primary and secondary sources were consulted. The novelty of the contribution has provided legal evidence and arguments that the relevant laws in Malaysia were to some extent, modern and advanced to recognise e-arbitration. However, from a purely legal perspective, several gaps should be appropriately addressed by Malaysian lawmakers in order to ensure the sustainable and successful establishment of e-arbitration in the country.
THE ANALYSIS OF TRUST INSTRUMENTS IN MALAYSIA AS ISLAMIC ESTATE PLANNING: THE CHALLENGES AND EFFECTS
Authors: Abdullah Muhamad Mu'izz , Awang Abdul Bari , Nor Muhamad Nasrul Hisyam
Published: June 2022

Efficient and effective Islamic estate planning not only provides convenience to Muslim but also capable of driving national economic progress and development. One of the instruments of Islamic estate planning is trust instrument which is based on Civil Law. The effect of not implementing the trust at an early stage can be seen in the property acquired as it is not managed effectively and indirectly harms the beneficiary. Therefore, this study will try to identify what are the challenges in the implementation of trust, which is not implemented efficiently and looking at the effects of late Islamic estate planning during a lifetime. This study is a qualitative study by analyzing previous articles, related statutes, and looking at the application of trust instrument in trust institutions in Malaysia. To achieve the objectives of this study, the authors conducted interviews with officers at Amanah Raya Berhad (ARB), which is the largest Public Trustee in Malaysia and this year has reached the 100th anniversary of its establishment. The finding of the study found that the trust instrument has significant effects in assisting Islamic estate planning. In conclusion, Islamic estate planning during a lifetime should not be taken lightly by society as it is detrimental to the family and national economy.
PERBANDINGAN METODE STREAM CIPHER DAN HILL CIPHER DALAM KEAMANAN DATA
Authors: Hidayatuloh Kamil , Yustantina Yustantina , Kusmadi Kusmadi
Published: June 2022

Keamanan data atau informasi menjadi topik yang selalu diperbincangkan khalayak ramai, kerahasiaan data dan informasi menjadi hal yang sangat penting untuk dijaga. Tetapi Kejahatan cyber makin sering kita dengar di media masa. Pelaku kejahatan memanfaatkan celah keamanan yang terdapat dalam sistem, untuk dimasuki dan dilakukan manipulasi sebuah data atau informasi. Kriptografi saat ini menjadi salah satu solusi yang banyak diminati karena sudah terbukti bisa mengamankan data dan informasi secara efektif. Bahkan, kriptografi sudah ada di dalam kehidupan kita saat ini, mulai dari transaksi di mesin ATM, Credit Card, mengakses internet, percakapan melalui telepon genggam sampai transaksi di dalam perdagangan elektronik (e-commerce). Pada penelitian ini digunakan metode algoritma Stream Cipher dan Hill Cipher. Berdasarkan hasil perbandingan antara kedua metode algoritma tersebut, dapat disimpulkan bahwasannya algoritma Stream Cipher dapat menjadi pilihan untuk mengamankan dan meminimalisir kebocoran data dan Informasi.
International Experience in the Development of the Payment Card Market and Problems with Functioning of Payment Cards in Ukraine
Authors:   Educational and Scientific Institute «Karazin Banking Institute» of V. N. Karazin Kharkiv National University, Volokhata Viktoriia Ye.
Published: June 2022

Cash, payment systems and instruments in modern conditions are the basis of the economy and life of each country, ensuring the possibility of exchange between the owners of certain goods or services, which, in turn, is one of the main conditions for the existence of credit and the State. The presence of a bank payment card gives its owner a number of advantages, including convenience during the calculation, reliability of saving the own funds, paying bills online. Bank payment cards are effective and profitable for all participants of the payment system, as evidenced by their rapid spread. For banking institutions, such operations bring profit in the form of commission income from servicing card accounts, accomplished transactions, as well as from an increase in the number of customers through the provision of new services, reducing the bank’s costs for servicing cash, etc. Bank payment cards are one of the most progressive tools for providing banking services. In the circumstances of the unstable situation in the financial market because of the hostilities on the territory of Ukraine, the coronavirus epidemic, the lack of financial resources, it becomes extremely necessary to expand and improve cashless payments due to the introduction of innovations in the payment card market. The article is aimed at summarizing the problems with functioning and development of the payment card market in Ukraine, along with the possibilities of using international experience to solve them. The article defines the advantages and disadvantages of practical use of payment cards in the financial market of Ukraine. Taking into account the mentioned shortcomings in the use of bank payment cards in non-cash payments, factors that hamper the development of the domestic payment card market are identified. The results of the study of the development of the payment card market allowed to outline the main problems of using payment cards in Ukraine. The ways of their solution are proposed and substantiated. International experience in the development of the payment card market is studied and analyzed
Financial and Tax Management in the Enterprise Management System
Authors:   Odesa National Academy of Food Technology, Ivanchenkova Larysa V. , Stepanenko Serhii V. ,   State Biotechnological University, Yevtushevska Olha O. ,   Odesa National Academy of Food Technology
Published: June 2022

The article considers the importance of effective development of tax management in enterprises. Weaknesses of the tax system that affect the activities of Ukrainian enterprises have been identified: frequent changes in the tax legislation of Ukraine, its contradictions, ambiguity and subjectivity in the interpretation of tax norms by regulatory authorities, law enforcement bodies, force owners and managers to look for ways to reduce the tax burden in order to strengthen its competitiveness in the market. It is analyzed how the COVID-19 pandemic affected the work of enterprises, including in the field of financial management. The process of tax management of the business entity is defined, which includes: target subsystem, providing subsystem, functional subsystem, management subsystem. The principles of tax planning, which can be classified into general and special, are considered. Ways to increase the effectiveness of tax management in the enterprise are formed: taking responsibility for control over tax risks, regularly and systematically participate in risk monitoring activities; cultivating appropriate thinking about risk. It is concluded that financial management together with the company's tax management will manage risks, release additional funds, thereby allowing to stabilize the company, give it the opportunity to develop and gain competitive advantage, which in the long run will increase the company's competitiveness.
The Socioeconomic and Political Profile of the Islamic Republic of Iran
Authors:   V. N. Karazin Kharkiv National University, Panova Iryna O. , Zhevaho Oleksandr K. ,   V. N. Karazin Kharkiv National University
Published: June 2022

Currently, the issue of renewing the nuclear deal remains a key factor in the d?tente and reset of relations between the Islamic Republic of Iran and Western countries. The success of the talks could stabilize the Middle East region and lead to the resumption of Iran’s close economic cooperation with international actors. At the same time, the public power, which is currently in the hands of conservative circles of the Iranian elite, and the presence of a significant part of hardliners in government circles of the United States and Israel prevent the rapid achieving of positive results via negotiations. Iran-Ukraine relations, despite considerable prospects, are currently de facto frozen due to a significant number of adverse factors. In addition, taking into account the important fact that today there is a significant intertwining of geopolitical processes in the international arena, one can state that the future of relations between the Islamic Republic of Iran and Ukraine lies in the solution of two tangential cases, namely: the Russian-Ukrainian war and the Iranian nuclear deal. The resolving of both situations lies with the international community, whose interests are closely intertwined. The development of Iran-Ukraine relations is possible and is strategically important for the formation of a zone of economic, political and military security in Europe, the Caucasus and the Middle East not only at present, but also for the future of the whole world. Given this, the Iranian direction of Ukrainian foreign policy needs a reset and an integrated approach even now. The object of the study of the article is the foreign policy of the Islamic Republic of Iran. The article is aimed at studying the socioeconomic and political profile of the Islamic Republic of Iran. As a result, it is concluded that Iran effectively uses all available opportunities to advance its own interests. Significant natural and human resources provide an opportunity to stabilize the economy and ensure its growth despite external and domestic political obstacles. The use of asymmetrical means allows to successfully resist the superior force of numerous regional opponents, while the «soft policy» provides the necessary human and financial resources.
Staging the Development of the National Market of Investment Financial Services
Authors:   The University of the State Fiscal Service of Ukraine, Kovalenko Yuliia M. , Yatsenko Ivan V ,   The University of the State Fiscal Service of Ukraine
Published: June 2022

The article is aimed at studying the current state and prospects for the development of the national market of investment financial services. The article describes the market of investment financial services along with subject classification. The activities of intermediaries in the market of investment financial services as of the end of 2008 – 01.04.2022 in Ukraine are analyzed. Diagnostics of the state of development of the market of investment financial services is carried out on the basis of indicators of the authors’ own development, in particular the indicators of market capacity, market indicators, indicators of economic significance of the activities of intermediaries, macroeconomic indicators. A periodization of stages of development of the national market of investment financial services is made. The impact of the global financial and economic crisis of 2008–2010, political instability in 2014, coronavirus crisis of 2020–2021, and the Russian invasion in 2022 on the functioning of intermediaries in the investment financial services market are specified. The activity of foreign investors in the purchase of assets in Ukraine, including the value and number of M&A transactions, is researched. It is prognosticated that the Russian aggression in 2022 may have catastrophic consequences for Ukraine in general and for the investment financial services market in particular, which has long recovered from the negative consequences of previous crisis periods and has not fully come to life from the global financial and economic crisis of 2008–2010. It is concluded that the modern market of investment financial services is not public enough and has significant shortcomings in the coverage of relevant information by regulators – the National Bank of Ukraine and the National Securities and Stock Market Commission. The relevance of creation of statistical databases from regulators of the market of investment financial services is substantiated. The advantages and disadvantages of investing assets of intermediaries in the market of investment financial services in government bonds is identified. Perspective directions of development of the national market of investment financial services are proposed
The Scientific and Theoretical Foundations of Formation of Business Environment of Territories
Authors:   Educational and Research Institute «Karazin Business School» of V. N. Karazin Kharkiv National University, Tretiak Viktoriia Р. , Chen Yuxi ,   Educational and Research Institute «Karazin Business School» of V. N. Karazin Kharkiv National University
Published: June 2022

Creating new opportunities for Ukrainian business is one of the priority directions of activity in the short and medium terms. The subject of the study is the theoretical and methodological foundations of the formation of the bases of the mechanism for managing the business environment of territories. In the scientific literature, the concept of «business environment» is often replaced by related categories that are used as synonyms. The level of «business environment» in the structural hierarchy of the concept of «environment» on the principle of increasing the degree of coverage of economic relations is determined. The understanding of the concept of «territory» is outlined from the point of view of the decentralization reform, which continues in Ukraine. Decentralization of power can be territorial – the transfer of power from the central city to other territories, and can be functional – by transferring decision-making powers from the main body of any branch of government to lower-level officials. The formation of a mechanism for managing the business environment of territories is considered in relation to the hierarchy of territorial distribution: the territory of the State, the territory of the region, the territory of the amalgamated hromada. The analysis of the opinions of scientists regarding the definition of the essence of the category of «business environment» is carried out. It is defined that in scientific thought there is no clear identification of the content of this term and there is an urgent need to determine the structure-forming elements of the mechanism for managing the business environment of territories. It is determined that the formation of business conditions is influenced by a number of factors according to a certain territorial level. Factors of influence are the external business environment, entrepreneurial environment, macroeconomic environment of entrepreneurial activity, institutional environment of entrepreneurial activity. The carried out analysis of the theoretical foundations of the formation of the business environment of the territories made possible to highlight the main features of the business environment as a system and its features at different levels of the territorial hierarchy.
Accounting for Costs in the Sphere of e-Commerce in Ukraine
Authors:   State Tax University, Opolinska Viktoriia V.
Published: June 2022

The rapid development of e-commerce affects the methodology of accounting, forming new tasks for modeling the behavior of business entities. In the presence on the net, having an own website, the efficiency of online advertising events increases, since any advertising may contain a link to the company’s website. To develop a website, the company bears certain costs, in particular: for services of creating a design, domain registration, promotion, website support, services for placing website data on the server, and others. The use of websites in the activities of e-commerce enterprises leads to the emergence of new objects to be reflected in accounting, thus it is necessary to determine the methods of evaluation, signs of classification and accounting methodology. At that, it should be noted that the legal and methodological documents regulating accounting do not fully reflect these changes and need to be supplemented. This article is concerned with substantiation of theoretical provisions and development of practical recommendations in terms of accounting for the costs of creating a website, its operation, promotion, and maintenance. Methodical approaches to accounting for the costs of creating a website are proposed, which should be improved taking into account such factors as: method of creation; stages of this process; identification of accounting procedures. The conducted research allowed to formulate criteria for recognizing the website as an intangible asset, which is important for improving the accounting policy of the enterprise. Thus, the presented methodology will help to form reliable accounting information that will avoid distortion of accounting data.
WAYS OF DEVELOPMENT OF THE TOURIST SPHERE OF UKRAINE IN THE WAR PERIOD
Authors: Roik Oksana , Nedzvetska Olga
Published: June 2022

The article is devoted to the study of the development of the Russian-Ukrainian war for the development of tourism in Ukraine. It is substantiated that in wartime Ukraine it is time for political science to understand the development of tourism as an object and subject of the political process and as an economic attractor, to deter-mine the state of national and regional economy and determine appropriate management decisions. Under such conditions, the tourism sector not only shapes the political ways, methods and means of tourism in the country, but causes the development (albeit indirectly) of solving some political and economic problems and functions of the state. The relevance of the study is due to the fact that it is currently characterized by the need to seek stabilization of economic and social development of society, as well as the formation of political opportunities for national action in the political process, where tourism to change the institutional structure. Research on the de-velopment of tourism is now particularly relevant in the context of the full-scale war in Ukraine and is studied in a number of scientific and practical works. The full-scale war began not so long ago, and at present there are not many publications and research on this topic. Studies show that the tourism business in Ukraine is at the stage of structural adjustment, institutional population, the formation of intra-industry, and intersectional, interregional and foreign economic relations. The tourist infrastructure is being improved, the corresponding segment of the labour market is being formed, and a new system of state regulation of tourist activity is being created. The facts of cultural crimes of the occupying forces on the territory of Ukraine and their consequences in the future are studied. The main factors influencing the socio-economic and ecological zone during the war are identified. The internal demand necessary for the normal functioning of the economy must decrease. Accurate estimates of this decline cannot be given at this time, but it is likely to be at least a third of the military level. Such a reduction is transformed into a corresponding fall in the country’s GDP. Also the key consequences for the development of the tourist sphere of Ukraine are described. The article identifies problems and prospects for the development of tourism in the war in Ukraine.
The Digital Reconstruction of Healthcare
Authors: Serrato Paul , Halamka John
Published: June 2022

В эпоху высокоскоростного Интернета, накапливаемых с гигантской скоростью больших данных и искусственного интеллекта, умных носимых устройств, считывающих десятки самых разнообразных данных о здоровье пациента, мир уже никогда не будет прежним. Какими в этом новом мире должны стать системы здравоохранения? И какими достижениями информатики мы должны воспользоваться, чтобы и в мирное время, и в периоды кризисов придать им устойчивость? На эти вопросы отвечают признанные мировые эксперты в области цифровых технологий из клиники Майо — Пол Серрато и Джон Халамка. Авторы рассказывают о том, какие цифровые технологии сегодня уже используются в здравоохранении: телемедицинские консультации, удаленный мониторинг пациентов, стационар на дому, системы поддержки принятия клинических решений, прогностические модели. Простыми словами они описывают принципы их внутреннего устройства, приводят данные о результатах внедрения и возможных рисках. Несомненный интерес представляет раздел о национальных стратегиях информатизации развитых стран. Все данные представлены через призму научных доказательств, материал сопровождается многочисленными практическими примерами и ссылками на дополнительные источники информации. Книга будет полезной и интересной медицинским работникам всех специальностей для осмысления неизбежных технологических перемен, происходящих в здравоохранении.
Spreading Hadith Maudhu’ Via Information And Communication Technology: Reasons And Suggestions
Authors: Binti Nik Fauzi Nik Suhaili , Hoque Mesbahul , Abd Kadir Kauthar
Published: June 2022

Hadith maudhu’ is a false and fabricated Hadith and has lied in the name of the Prophet Muhammad SAW, and such things were never done by the Prophet.  This paper aims to study the spreading of hadith maudhu’ in the ICT era, to identify the reasons for spreading hadith maudhu’, and to suggest several guidelines to inhibit hadith maudhu’ from spreading further. The study uses a qualitative method based on library research by analyzing studies and past documents as well as the textual content of materials in the form of books, journals, articles related to Hadith Maudhu’. The results of this study found that the awareness of Muslims nowadays about the spread of false hadith is unsatisfactory, as they are more dependent on sharing through ICT without checking its authenticity first. Therefore, pious Muslims should always be concerned about a sharing that involves sensitivity towards religion, including the spread of hadith Maudhu’.
Koncentracija aktivnosti prirodnih radionuklida u hrani za piliće u Republici Sjevernoj Makedoniji
Authors: Angeleska Aleksandra , Crceva Nikolovska Radmila , Angelovski Ljupcho , Uzunov Risto , Dimzoska Stojanovska Biljana , Blagoevska Katerina , Dimitrieska Stojkovik Elizabeta
Published: June 2022

The care of radioactivity level in animal feed is very important, as ingestion is one of the most common ways radionuclides enter living organisms. Thus, since humans consume products of animal origin (eggs and poultry, milk and beef), it is important to monitor radiation levels in animal feed, as part of the radioactivity that these animals are exposed to, could be transmitted to humans. Natural radionuclides such as 40K, 232Th and 226Ra find their way into the food chain from soil and air to plants and from plants to animals and humans as well. The goal of this study was to determine the activity concentrations of natural radionuclides in three commercial chicken feeds – starter, grower and finisher. The analyzes were performed by means of HPGe gamma spectrometry - gamma spectrometer (Canberra Packard) with a high-purity germanium detector. The obtained spectra from the measurement were analyzed by using the program GENIE 2000. Based on the performed tests, the mean values for the activity concentrations in the samples were the following 26.03±4.1 Bq kg-1 for 226Ra, 37.9±4.8 Bq kg-1 for 232Th, and 64.40±6.5 Bq kg-1 for 40K. The results obtained from the analyses of chicken feeds were compared to studies in other countries and it was found that 40K was present in the highest amount in all types of samples while the vales for the other natural radionuclides were within the nominal concentrations. Higher concentration of 40K can be associated with plants used in the production of animal feed, which were contaminated with fertilizer during their cultivation. The range of radionuclide concentrations in the samples was within the recommended values UNSCEAR.
Comparison of autologous and allogeneic hematopoietic cell transplantation strategies in patients with primary plasma cell leukemia, with dynamic prediction modeling
Authors: Lawless Sarah , Iacobelli Simona , Knelange Nina Simone , Chevallier Patrice , Blaise Didier , Milpied Noel , Foà Roberto , Cornelissen Jan J. , Lioure Bruno , Benjamin Ruben , Poiré Xavier , Minnema Monique C. , Collin Matthew , Lenhoff Stig , Snowden John A. , Santarone Stella , Wilson Keith M. O. , Trigo Fernanda , Dreger Peter , Böhmer Lara H. , Putter Hein , Garderet Laurent , Kröger Nicolaus , Yaukoub-Agha Ibrahim , Schönland Stefan , Morris Curly
Published: June 2022

Primary plasma cell leukemia (pPCL) is a rare and challenging malignancy. There are limited data regarding optimum transplant approaches. We therefore undertook a retrospective analysis from 1998-2014 of 751 patients with pPCL undergoing one of four transplant strategies; single autologous transplant (single auto), single allogeneic transplant (allo-first) or a combined tandem approach with an allogeneic transplant following an autologous transplant (auto-allo) or a tandem autologous transplant (auto-auto). To avoid time bias, multiple analytic approaches were employed including Cox models with time-dependent covariates and dynamic prediction by landmarking. Initial comparisons were made between patients undergoing allo-first (n=70) versus auto-first (n=681), regardless of a subsequent second transplant. The allo-first group had a lower relapse rate (45.9%, 95% confidence interval [95% CI]: 33.2-58.6 vs. 68.4%, 64.4-72.4) but higher non-relapse mortality (27%, 95% CI: 15.9-38.1 vs. 7.3%, 5.2-9.4) at 36 months. Patients who underwent allo-first had a remarkably higher risk in the first 100 days for both overall survival and progression-free survival. Patients undergoing auto-allo (n=122) had no increased risk in the short term and a significant benefit in progression-free survival after 100 days compared to those undergoing single auto (hazard ratio [HR]=0.69, 95% CI: 0.52- 0.92; P=0.012). Auto-auto (n=117) was an effective option for patients achieving complete remission prior to their first transplant, whereas in patients who did not achieve complete remission prior to transplantation our modeling predicted that auto-allo was superior. This is the largest retrospective study reporting on transplantation in pPCL to date. We confirm a significant mortality risk within the first 100 days for allo-first and suggest that tandem transplant strategies are superior. Disease status at time of transplant influences outcome. This knowledge may help to guide clinical decisions on transplant strategy.
Axicabtagene ciloleucel compared to tisagenlecleucel for the treatment of aggressive B-cell lymphoma
Authors: Kwon Mi , Iacoboni Gloria , Reguera Juan Luis , Corral Lucía López , Morales Rafael Hernani , Ortiz-Maldonado Valentín , Guerreiro Manuel , Caballero Ana Carolina , Domínguez María Luisa Guerra , Pina Jose Maria Sanchez , Mussetti Alberto , Sancho Juan Manuel , Bastos-Oreiro Mariana , Catala Eva , Delgado Javier , Henriquez Hugo Luzardo , Sanz Jaime , Calbacho María , Bailén Rebeca , Carpio Cecilia , Ribera Jose Maria , Sureda Anna , Briones Javier , Hernandez-Boluda Juan Carlos , Cebrián Nuria Martínez , Martin Jose Luis Diez , Martín Alejandro , Barba Pere
Published: June 2022

Axicabtagene ciloleucel (axi-cel) and tisagenlecleucel (tisa-cel) are CD19-targeted chimeric antigen receptor (CAR) T cells approved for relapsed/refractory (R/R) large B-cell lymphoma (LBCL). We performed a retrospective study to evaluate safety and efficacy of axi-cel and tisa-cel outside the setting of a clinical trial. Data from consecutive patients with R/R LBCL who underwent apheresis for axi-cel or tisa-cel were retrospectively collected from 12 Spanish centers. A total of 307 patients underwent apheresis for axi-cel (n=152) and tisa-cel (n=155) from November 2018 to August 2021, of which 261 (85%) received a CAR T infusion (88% and 82%, respectively). Median time from apheresis to infusion was 41 days for axi-cel and 52 days for tisa-cel (P=0.006). None of the baseline characteristics were significantly different between both cohorts. Both cytokine release syndrome and neurologic events (NE) were more frequent in the axi-cel group (88% vs. 73%, P=0.003, and 42% vs. 16%, P<0.001, respectively). Infections in the first 6 months post-infusion were also more common in patients treated with axi-cel (38% vs. 25%, P=0.033). Non-relapse mortality was not significantly different between the axi-cel and tisa-cel groups (7% and 4%, respectively, P=0.298). With a median follow-up of 9.2 months, median PFS and OS were 5.9 and 3 months, and 13.9 and 11.2 months for axi-cel and tisa-cel, respectively. The 12-month PFS and OS for axi-cel and tisa-cel were 41% and 33% (P=0.195), 51% and 47% (P=0.191), respectively. Factors associated with lower OS in the multivariate analysis were increased lactate dehydrogenase, ECOG ≥2 and progressive disease before lymphodepletion. Safety and efficacy results in our real-world experience were comparable with those reported in the pivotal trials. Patients treated with axi-cel experienced more toxicity but similar non-relapse mortality compared with those receiving tisa-cel. Efficacy was not significantly different between both products.
IgM monoclonal gammopathies of clinical significance: diagnosis and management
Authors: Khwaja Jahanzaib , D’Sa Shirley , Minnema Monique C. , Kersten Marie José , Wechalekar Ashutosh , Vos Josephine M.
Published: June 2022

IgM monoclonal gammopathy of undetermined significance is a pre-malignant condition for Waldenström macroglobulinemia and other B-cell malignancies, defined by asymptomatic circulating IgM monoclonal protein below 30 g/L with a lymphoplasmacytic bone marrow infiltration of less than 10%. A significant proportion, however, develop unique immunological and biochemical manifestations related to the monoclonal protein itself in the absence of overt malignancy and are termed IgM-related disorders or, more recently, monoclonal gammopathy of clinical significance. The indication for treatment in affected patients is dictated by the pathological characteristics of the circulating IgM rather than the tumor itself. The clinical workup and treatment options vary widely and differ from those for Waldenström macroglobulinemia. The aim of this review is to alert clinicians to IgM monoclonal gammopathy of clinical significance and to provide practical guidance on when to screen for these phenotypes. We discuss clinical characteristics, the underlying clonal profile, diagnostic workup and treatment considerations for five important subtypes: cold agglutinin disease, type I and II cryoglobulinemia, IgM-associated peripheral neuropathy, Schnitzler syndrome and IgM-associated AL amyloidosis. The inhibition of the pathogenic effects of the IgM has led to great success in cold agglutinin disease and Schnitzler syndrome, whereas the other treatments are centered on eradicating the underlying clone. Treatment approaches in cryoglobulinemia and IgM-associated peripheral neuropathy are the least well developed. A multidisciplinary approach is required, particularly for IgM-related neuropathies and Schnitzler syndrome. Future work exploring novel, clone-directed agents and pathogenic IgM-directed therapies is welcomed.
ШЛЯХИ ПІДВИЩЕННЯ ЕФЕКТИВНОСТІ ВОДНИХ ВОГНЕГАСНИХ РЕЧОВИН НА ОСНОВІ РІДКОГО СКЛА
Authors: Кодрик Анатолій , Коваленко Віталій , Тітенко Олександр , Борисов Андрій , Стилик Iгор , Борисова Анна
Published: June 2022

Розглянуто особливості взаємодії водних вогнегасних речовин з горючими середовищами і поверхнями горіння твердих горючих речовин як підґрунтя покращення показників якості наявних та розроблення нових зразків водних вогнегасних речовин з використанням гелеутворювальних сполук на основі рідкого скла, а також підвищення вогнегасної ефективності під час їх застосування в елементах систем протипожежного захисту об’єктів та пожежогасіння. Наведено результати лабораторних та натурних випробувань, що доводять доцільність поєднання компонентів рідкого натрієвого скла та поташу в складі вогнегасних гелеутворювальних сполук. Проаналізовано сучасний стан щодо наявності та тенденцій розроблення у світовій та вітчизняній практиці вогнегасних речовин та технологій їх застосування. Окреслено можливі шляхи удосконалення рецептур та підвищення ефективності застосування вогнегасних речовин насамперед з огляду на критерії ефективності, економічності та екологічності. Доведено, що порівняно з водою вогнегасні розчини на основі модифікованих систем та нових технологій їх продукування мають ряд переваг, які полягають в суттєвому збільшенні їх стійкості та адгезійних властивостей, підвищенні вогнезахисної дії через утворення під час подавання на полум’я пористого шару або плівки. Це ускладнює займання та захищає горючий матеріал внаслідок низької теплопровідності та ізолювання від доступу кисню повітря, що важливо у разі гасіння поверхневих пожеж класу А. На підставі аналізу використаних джерел, а також власних теоретичних та експериментальних досліджень сформовано наукову базу для подальшого науково-технічного прогресу у практичній діяльності виробників та споживачів продукції протипожежного призначення. Запропоновано шляхи удосконалення складів водних вогнегасних речовин та технологій їх застосування.
Response of Growth, Biomass Production and Nutrient Uptake of Red Amaranth (Amaranthus Tricolor L.) To Various Organic Manures and Chemical Fertilizers
Authors: H Zaman , Suchi SJH , Tabassum N , Rahman MK
Published: June 2022

A pot experiment was conducted at the Department of Soil, Water and Environment, University of Dhaka, from 10 January to 24 February 2021, to evaluate the growth parameters, biomass production, and nutrient uptake of red amaranth (Amaranthus tricolor L.) as influenced by different types of organic manures manufactured by companies, viz. ACI, Agro, Kazi, Mazim, McDonald, Naafco, Paragon and Sharib, and by 50% of recommended dose of NPK fertilizers. The experiment consisted of ten treatments with three replications each and was laid out in a Completely Randomized Design (CRD). On the day of harvest, Naafco displayed the greatest number of leaves (10.67±2.31), the longest leaf length (8.60 ± 2.07 cm), and the largest leaf area (275.10±118.8 cm2 plant-1), whereas the highest plant height (24.53±3.27cm) and stem girth (24.53±3.27cm) were observed in McDonald. Conversely, Kazi exhibited the poorest performance in all aforementioned parameters. Both the highest fresh and dry weights (10.75±6.09 g plant-1 and 1.31±0.87 g plant-1 respectively) were recorded in Naafco treated plants, and the lowest weights in Kazi (1.98 g plant-1 and 0.23 g plant-1 respectively). The highest total nutrient content (NPKS and Fe) (46.02 mg plant-1) in plants was found in Naafco, while the lowest was in Kazi (3.96 mg plant-1). Judging from the results, Kazi treated plants consistently showed the lowest growth, biomass, and nutrient accumulation.
J. Biodivers. Conserv. Bioresour. Manag. 2021, 7(2): 73-82
Development of an AI model for electronic board maintenance decision prediction for railway equipment
Authors: Li Ken Yat Hung , Leung John See Jing , Lau Laura Ming Wai
Published: June 2022

Railway equipment is required to work fault-free under rugged conditions such as continuous operating heat loads. One of the most important considerations in railway maintenance is the ability to predict failure, due to aging, early enough such that spare parts can be acquired just-in-time which normally takes a lead time of several weeks to up to around a year from the supplier. This study has conceived and tested the RUS Boost Ensemble machine learning algorithm to predict maintenance decisions of railway electronic boards based on measurable component values. Some traditional approaches like MIL-217 are commonly used for electronic reliability prediction but these types of approaches do not consider load profiles, failure root causes, and practical limitations in the number of available experimental test samples. This study develops a prognostic approach by considering actual load conditions and life limiting factors, and utilises machine learning algorithms to build the model. The model also makes use of real-life test samples from lab ALT (Accelerated Life Testing). After development of the AI model to predict electronic board component maintenance, the test results revealed the predictive accuracy to have up to 95% correlation for the red/urgent category and 94% for the yellow/medium-urgency category.
Effective real-time face mask detection on NVIDIA edge devices
Authors: Kam Ho Chuen , Lui Nathan Chung Kan , Du Ethan Yi Chen , Lui Marcus Ngai Kan , Chan Chun Sing , Cheung Yan Ting , Cheung Ka Chun , Leung Monica Sze Man
Published: June 2022

During these difficult times of COVID-19, people are struggling to return to their normal routines, including going back to schools and workspaces. To prevent the spread of the disease, wearing face masks is essential for everyone to protect themselves and the ones around them. However, challenges arise in regard to enforcement of wearing masks in large crowds such as at educational centres and public transportation. This paper proposes a robust automatic system for face mask detection using transfer learning kits from NVIDIA. Based on the backbone of Resnet-18, the model results in high accuracy in the distinguishing of persons who do and do not wear masks. Leveraged by the NVIDIA edge accelerator, the system can run in real-time environments, making it applicable in various venues. Its feasibility was demonstrated by deploying the approach in an education centre in Hong Kong.
Multiple structural defect detection for reinforced concrete buildings using YOLOv5s
Authors: Li Chaobin , Pan Wei , Yuen Pong Chi , Su Ray K L
Published: June 2022

Building inspection and maintenance are becoming increasingly essential means by which to consider the deterioration problems of old, reinforced concrete (RC) buildings. While such inspection work can be conducted with the aid of computer vision-based technology, this technology remains challenged, since real-world structural defects and environmental conditions are varied and complex. In recent years, object detection algorithms have improved to achieve greater speed and accuracy with the help of deep learning. In this paper, an advanced object detector, YOLOv5s, was successfully applied to the recognition of common structural defects including cracks, delamination, exposed reinforcement, rust stains, spalling, tile cracks, tile delamination, and tile loss. Compared with the other advanced object detectors of YOLO (i.e., YOLOv5m, YOLOv5l, YOLOv5x, YOLOv4, and YOLOv3) based on the built data set, the YOLOv5s algorithm shows an obvious advantage for defect detection, achieving 64.5% and 67.0% mean average precision (mAP) for training and testing, respectively. It also takes less than 0.1 seconds to detect a defect on an image. The lightweight and high detection performance of the YOLOv5s algorithm shows great promise for potential deployment on an onboard inspection device, such as an unmanned aerial vehicle (UAV) or a robot, to achieve real-time structural inspection.
On Bifurcations Along the Spiral Organization of the Periodicity in a Hopfield Neural Network
Authors: DA SİLVA Angela , RECH Paulo
Published: June 2022

In this work we report numerical results involving a certain Hopfield-type three-neurons network, with the hyperbolic tangent as the activation function. Specifically, we investigate a place of a two-dimensional parameter-space of
this system where typical periodic structures, the so-called shrimps, are embedded in a chaotic region. We show that these structures are organized themselves as a spiral that coil up toward a focal point, while undergo period-adding bifurcations. We also indicate the locations along this spiral in the parameter-space, where such bifurcations happen.
Conformal Quasi-Hemi-Slant Riemannian Maps
Authors: YANAN Şener
Published: June 2022

In this paper, we state some geometric properties of conformal quasi-hemi-slant Riemannian maps from almost Hermitian manifolds to Riemannian manifolds. We give necessary and sufficient conditions for certain distributions to be integrable and get examples. For such distributions, we examine which conditions define totally geodesic foliations on base manifold. In addition, we apply notion of pluriharmonicity to get some relations between horizontally homothetic maps and conformal quasi-hemi-slant Riemannian maps.