bluuebunny/crossref_metadata_2025 huggingface dataset:
Multifocal superficial thrombophlebitis of the extremities in HIV infection
Authors: Myshentsev P. N. , Katorkin S. E.
Published: May 2024

Long-term observations indicate an increased risk of developing venous thromboembolic conditions in people with the human immunodeficiency virus, their tendency to relapse or a widespread nature. In addition, the incidence of thrombosis increases several times in HIV-infected people compared to the average rates characteristic of people of the same age. A clinical case of multiple bilateral lesions of the subcutaneous veins of the upper and lower extremities in a young patient with HIV infection is presented. Ineffective outpatient treatment and ascending superficial thrombophlebitis of the lower extremities required emergency hospitalization and surgical treatment of the patient to prevent thromboembolic complications. In the postoperative period, in order to prevent the progression of the thrombotic process, as well as to relieve the symptoms of an acute inflammatory reaction of the venous wall and paravasal tissues, a complex application of compression therapy, modern oral anticoagulant drugs, phlebotropic drugs with proven efficacy was carried out. The postoperative period proceeded without complications. In the next few days, the patient’s condition improved, there was a clear regression of thrombotic limb damage. Conclusion: In case of multiple thrombotic lesions of the subcutaneous veins of the upper and lower extremities on the background of HIV infection, the combination of timely surgical intervention with systemic anticoagulant therapy and phlebotropic agents of general and topical use has significant effectiveness in the medical rehabilitation of the patient.
Biological therapy of bariatric surgery complications
Authors: Khitaryan A. G. , Mezhunts A. V. , Oplimakh K. S. , Orekhov A. A. , Melnikov D. A. , Adizov S. A. , Kislyakov V. N. , Abovyan A. A.
Published: May 2024

In recent years, the number of performed bariatric interventions has increased significantly. Despite the high effectiveness of this method of treatment, the occurrence of complications is not uncommon. The most common complications are stapler line leaks, occurring in 1.5–2.4% of cases; anastomotic leakage after One Anastomosis Gastric Bypass – in 2.2–8% of cases. The problem with all methods is the increased duration of treatment and the need to go without food for significant periods of time, which means starting parenteral nutrition and risking malnutrition. The article demonstrates the effectiveness of biological therapy for complications of bariatric surgery in a series of clinical cases. Clinical cases of 2 patients with anastomotic leakage after One Anastomosis Gastric Bypass are described; also 2 patients with incompetent staple line after laparoscopic Sleeve Gastrectomy. PRP therapy, stromal vascular fraction (SVF) and fibrin glue were used. Platelet-rich plasma is an autologous blood serum containing high concentrations of platelets and growth factors. As a result, after 4 courses of PRP therapy, the patient with the failure of the upper third of the stapler line received an application of twocomponent fibrin glue “Kriofit” with a positive effect. In addition, positive dynamics was observed in the patient with the use of threecomponent therapy of anastomotic leakage. Based on the above facts, it can be concluded, that biological therapy demonstrates great potential value in the treatment of bariatric surgery complications such as stapler line leaks, and anastomotic leakage.
Experts’ views on recurrence and progression of varicose veins
Authors: Bogachev V. Yu. , Alukhanyan O. A. , Vanyan G. N. , Markin S. M. , Artemova A. S. , Kravtsov P. F.
Published: May 2024

Introduction. Despite modern advances in technologies for the treatment and prevention of varicose veins, there is currently no radical treatment for varicose veins. The probability of recurrence of dilated veins, according to various authors, ranges from 5 to 70%. Along with the well-established concept of recurrence of varicose veins, the term progression of varicose veins is increasingly common in everyday life.

Aim. To study the current understanding of the term relapse and the practical attitude of specialists involved in the treatment of varicose veins to it.

Material and methods. In 2023, a survey of 117 specialists on the recurrence/progression of varicose veins was conducted. The respondents were doctors involved in the treatment of varicose veins: vascular surgeons 22.4%, phlebologists 50%, general surgeons 19.8%, specialists in ultrasound/functional diagnostics 7.8%, X-ray endovascular surgeon 0.85%. The questionnaire included 18 questions regarding the frequency of visits of patients with relapse/progression of varicose veins; views on tactics, as well as the attitude of specialists to the issue of progression and recurrence of varicose veins in patients after its surgical treatment.

Results and discussion. The concept of recurrence and progression of varicose veins among specialists dealing with this pathology is not always comparable. There are differences in views both on the predisposing factors for the recurrence of dilated veins, and, accordingly, on the tactics of treatment and preventive measures. In some cases, according to statistics, they are due to specialization.

Conclusions. The incidence of relapse and progression at the reception of the respondents has a slight difference. Despite the fact that there are opinions that do not correspond to generally accepted and abhorrent collegiality, mostly specialists try to separate these concepts, see differences in provoking factors and, accordingly, in recommendations.
Hücre ve Bölünmeler Ünitesinin İşlenmesinde Eğitsel Dijital Oyunların Etkisi
Authors: Pınar Mehmet Ali , Dönel Akgül Güldem
Published: May 2024

Bu çalışma, ortaokul 7. sınıf fen bilimleri dersinde "Hücre ve Bölünmeler" ünitesinin dijital oyunlar aracılığıyla işlenmesinin öğrenci performansları ve öğrenme deneyimleri üzerindeki etkilerini incelemeyi amaçlamaktadır. Araştırma, karma bir yöntem kullanarak hem nicel hem de nitel veri toplamayı hedeflemektedir. Nicel veriler, deney ve kontrol gruplarındaki öğrencilerin başarı testi, dijital teknolojiye yönelik tutum ölçeği ve fen öğrenmeye yönelik motivasyon ölçeği üzerinden değerlendirilmiştir. Nitel veriler ise yapılandırılmış görüşmeler ve öğrenci günlükleri aracılığıyla elde edilmiştir. Örneklemin 43 ortaokul yedinci sınıf öğrencisinden oluştuğu bu çalışmada, deney grubu dijital oyunlarla desteklenmiş öğretim alırken, kontrol grubu geleneksel ders kitaplarıyla eğitim görmüştür. Araştırma bulguları, deney grubundaki öğrencilerin dijital oyunlarla desteklenen öğretimden elde ettikleri başarı sonuçlarının kontrol grubuna göre anlamlı derecede yüksek olduğunu göstermektedir. Bu başarı artışının sadece anlık değil, aynı zamanda kalıcılık testinde de devam ettiği gözlemlenmiştir. Bu durum, dijital oyun tasarımının öğrenilen bilgilerin uzun süreli anlamda hatırlanmasına katkı sağlayabileceğini öne sürmektedir. Motivasyon ölçeği sonuçları, deney grubundaki öğrencilerin dijital oyunlarla işlenen derslere daha fazla ilgi gösterdiklerini ve motivasyonlarının yüksek olduğunu ortaya koymaktadır. Ancak, öğrencilerin dijital teknolojiye yönelik tutumlarında belirgin bir değişiklik olmamıştır. Bu durum, dijital oyun tasarımının motivasyonu artırma konusundaki etkili rolüne rağmen, teknolojiye yönelik tutumları değiştirmede yetersiz olduğunu göstermektedir. Öğrenci günlükleri ve yapılandırılmış görüşmelerde ifade edilen memnuniyet, öğrencilerin dijital oyun tasarımını olumlu bir şekilde değerlendirdiklerini ve bu yöntemin öğrenmeyi eğlenceli kıldığını vurgulamaktadır.
presidente no personifica a la nación. Un estudio sobre su naturaleza representativa
Authors: Acosta Yparraguirre Eduardo Martín
Published: May 2024

La idea de la personificación de la Nación como propia de la institución presidencial se ha instalado en el Perú a partir de las tres últimas Constituciones (1933, 1979 y 1993), apoyada por una apreciación general que le atribuye carácter declarativo, inocuidad o tradición y que ha normalizado la frase hasta el punto del silencio crítico. Sin embargo, no sólo es extraña a la institución, sino que resulta perjudicial para el entendimiento correcto de la representación democrática, dado que es más propia de las monarquías absolutas e incluso en su versión original estadounidense, en la que el poder presidencial continúa en expansión, la figura no aparece y tampoco en los constitucionalismos latinoamericanos, lo que revela no sólo su inconsistencia, sino su nocividad para el sistema republicano.
Addiction Management in Vulnerable Populations
Authors: Dave Pallav
Published: May 2024

Addiction remains a significant challenge, especially for vulnerable populations. As a way to cope with social determinants of health, life stressors and challenges they are going through, most result in substance abuse. Considering the number of people affected by SUD in the US, there is a need to put effective measures in place that can help address the challenges of dealing with addiction in vulnerable populations. Other than addressing the root causes of addiction in these populations, there is a need to take into account the individual needs of these groups to increase the likelihood of positive outcomes. Some of the needs that clinicians need to consider are lack of medical insurance, the inability to pay insurance, challenges with housing, historical trauma, structural racism, and discrimination. These factors can make it difficult to attain positive outcomes when dealing with vulnerable groups. Therefore, taking them into account is important. Community-based interventions can also help because they bring treatment close to patients. They also provide social support which most people facing vulnerabilities lack.
Penerapan Arsitektur Islam pada Perancangan Tugu UIN Ar-Raniry Banda Aceh
Authors: Rizky Humairi Muhammad , Fahlevi Raendra , Alfitri Mira
Published: May 2024

UIN Ar Raniry is one of the state Islamic campuses located in Banda Aceh. UIN Ar-Raniry is committed to promoting a moderate, open and inclusive understanding of Islam, and respecting cultural and religious diversity. Landmarks as the main element in the structure of the city. Landmarks have a very significant function in assisting individuals in determining directions and identifying cities as a whole, including other similar cities. The application of the UIN Ar-Raniry Monument which is on campus by promoting Islamic values.
This monument is expected to become a landmark that reflects Islamic identity and values and provides a spiritual experience for visitors. The approach used in designing this monument includes the use of elements of Islamic architecture, such as geometric motifs, ornate calligraphy, and distinctive repetitive patterns. In this study, researchers analyze and study Islamic design principles that are relevant to designing monuments. These principles include unity, proportion, balance and harmony which inform the placement of elements and the relationship between the parts of the monument. Researchers also consider the use of materials and construction techniques that are in accordance with Islamic architectural traditions, such as the use of stone, marble or wood as well as traditional techniques such as carving, mosaic or stucco. The research method that can be used for researchers is a qualitative method. Where researchers conduct interviews with related parties
ESTRUTURAÇÃO, ARCABOUÇO METODOLÓGICO E APLICAÇÃO DO CURSO DE ESPECIALIZAÇÃO “CIÊNCIA É 10!”
Authors: Arantes Alessandra Riposati , Carvalho Daniela Franco , Garcia Ducinei , Paes Fabíola do Nascimento Santos , Vasconcelos Rosa Maria Oliveira Teixeira de
Published: May 2024

Este texto é uma composição coletiva baseada na pesquisa narrativa da estruturação, do arcabouço metodológico e da aplicação do curso de especialização Ciência é 10! cuja fundamentação é o ensino de ciências por investigação. O objetivo desse trabalho foi narrar a proposição de um curso nacional de formação continuada, em nível de especialização, para professores do Ensino Fundamental na área de Ciências, na modalidade semi-presencial, utilizando plataforma de ensino a distância Moodle e a estrutura da UAB - Universidade Aberta do Brasil. Como resultados, apresentamos as experiências que tivemos no decorrer da aplicação piloto, por meio de análise das atividades pedagógicas a partir de relatos narrativos da equipe proponente do curso.
The effectiveness of Non-invasive Brain Stimulation (NIBS) in combination with Cognitive Analytic Therapy (CAT); a complex cocaine abuser case
Authors: Khodayarifard Mohammad , Kamranvand Mahnoosh , Rostami Reza
Published: May 2024

Drug addiction, a global problem affecting 275 million people, is a
complex disorder characterized by compulsive substance use despite
negative consequences. Neuroplasticity changes in the brain’s circuits,
particularly those involving dopamine, play a crucial role in addiction.
Non-invasive brain stimulation techniques, such as transcranial magnetic
stimulation and transcranial direct current stimulation, show promise as
adjunctive treatments for substance use disorders, including cocaine use
disorder. Combining these brain stimulation therapies with psychological
interventions may enhance treatment outcomes and reduce relapse rates.
In this study, a 38-year-old Iranian woman, diagnosed with cocaine use
disorder, underwent a multi-faceted neuropsychological treatment
program. Her husband also received psychological treatment but not
biological treatment. After treatment, both the woman and her husband
were able to completely stop using cocaine for more than three years.
The study used various assessments, including self-report tests and
brain mapping, to evaluate the effectiveness of the interventions. The
woman showed a significant reduction in symptoms and improvement in mood
regulation. This study highlights the effectiveness of a multifaceted
approach to treating cocaine addiction, including neurological and
psychological interventions. It suggests that non-invasive brain
manipulation and Cognitive Analytic Therapy (CAT) may be effective in
treating complex cases. However, further research is needed to establish
the efficacy of CAT for bipolar affective disorder. The study emphasizes
the importance of considering biological, psychological, and social
factors in the treatment of substance use disorders.
Mittag-Leffler type functions of three variables
Authors: Yuldashova Hilola , Hasanov Anvar
Published: May 2024

In this article, we generalized Mittag-Leffler-type functions F~̵̄ A ( 3 )
, F~̵̄ B ( 3 ) , F~̵̄ C ( 3 ) and F~̵̄ D ( 3 ) , which correspond,
respectively, to the familiar Lauricella hypergeometric functions F A (
3 ) , F B ( 3 ) , F C ( 3 ) and F D ( 3 ) of three variables. Among the
various properties and characteristics of these three-variable
Mittag-Leffler-type function F~̵̄ D ( 3 ) , which we investigate in this
article, include their relationships with other extensions and
generalizations of the classical Mittag-Leffler functions, their
three-dimensional convergence regions, their Euler-type integral
representations, their Laplace transforms, their connections with the
Riemann-Liouville operators of fractional calculus, and the systems of
partial differential equations which are associated with them.
Enhancing Resilience of LFC Systems Against False Data Injection Attacks via Active Disturbance Rejection Control
Authors: Zheng Zhou
Published: May 2024

In response to the security threats faced by multi-area interconnected
power systems, particularly various potential attacks, a security
protection scheme based on an extended state observer is proposed. The
proposed approach extends the state vector by introducing new variables,
allowing disturbances and attacks to be treated as additional state
variables within the system. Through the utilization of the extended
state observer, separate estimations of interference and external
attacks can be obtained, thereby enhancing the power system resilience
against potential threats. Based on this, a threshold-based attack
detection algorithm is proposed. In simulation experiments, the model of
the multi-area interconnected power system is studied under various
attacks such as step attacks, ramp attacks, and periodic attacks using
active disturbance rejection control (ADRC). Based on the performance
comparison between traditional PI control and ADRC, it has been
demonstrated that the ADRC method exhibits significant advantages in
improving system response speed and enhancing control accuracy.
THE IMPACT OF TEACHER-STUDENTS RELATIONSHIP ON ENGLISH STUDENTS’ MOTIVATION (A SURVEY ON THE FIRST YEAR ENGLISH DEPARTMENT STUDENTS)
Authors: Afrilia Alicia
Published: May 2024

The impact of teacher-student relationships on the motivation of English language learners (ELLs) is a crucial topic in the field of language education, particularly in a multilingual and culturally diverse country such as Indonesia. This study aims to provide an evidence of the link between teacher and student relationships and the motivation among ELLs in Indonesia. The researcher collected, analyzed, and compared the data obtained for this study by using a survey study design. Moreover, the researcher conducted structured interviews with ELL first-year English students to gather additional data. The findings of this study show that teachers at the university investigated, as perceived by students, exhibit a wide range of positive attitudes that positively influence student motivation. The most preferred attitudes among students were Academic Support, Responsible, and Moral Support, which emerged as the most preferred attitude among students. The results of this research show that a supportive classroom environment can enhance learners' motivation throughout their language learning journey, ultimately enhancing their language acquisition and overall success in language learning. This study provides valuable insights for educators and policymakers seeking to create an inclusive, supportive learning environment for their students. The study suggests that further studies could broaden the scope to include students from other faculties or universities. This would provide a more comprehensive understanding of lecturer attitudes and their impact on student motivation across different academic settings.
ACCRUAL EARNINGS MANAGEMENT, REAL EARNINGS MANAGEMENT, AND COST OF DEBT: DOES CAPITAL STRUCTURE MATTER?
Authors: Firmansyah Amrie , Prakosa Dani Kharismawan , Al ‘Alam Muhammad Panji Anugerah , Pamungkas Pria Aji , Geno Muchamad Rizal Pua , Fauzi Irfan , Bachtiar Muchamad Izaaz Hannun
Published: May 2024

This study looks at how accrual and real earnings management affect the cost of debt. This study also considers capital structure as a moderating variable. This quantitative study draws on data from the financial statements of manufacturing businesses listed on the IDX from 2016 to 2020. The research data was gathered from www.idnfinancial.com. Purposive sampling is employed in this study, with a sample size of 565 observations. Multiple linear regression analysis was employed to evaluate hypotheses with panel data. According to this study, accrual earnings management is unrelated to the cost of debt. Meanwhile, real earnings management correlates favorably with the cost of debt. The moderating influence of capital structure is often missing or minor in the link between real earnings management and the cost of debt. This research enriches the knowledge discussing the hazards of earnings management performed by managers in organizations with specific debt levels.
HERDING BEHAVIOR IN THE SHARIA CAPITAL MARKET ON INVESTMENT DECISIONS
Authors: Yahya Adibah , Affandi Azhar , Herwani Aldrin , Hermawan Atang , Suteja Jaja
Published: May 2024

Herding behaviour is an irrational decision-making because it is the following of other investors. Using information asymmetry as a moderating variable, this research aims at identifying the factors that influenced investment decisions. The research object was the Jakarta Islamic Index, and the data used were quarterly data from 2019 to 2021. The methods of sampling and analysis used were the panel data regression method and the purposive sampling method. The results showed that volatility, exchange rate, market sentiment and firm size positively and significantly affected herding behaviour. Information asymmetry strengthened the influence of herding behaviour on investment decisions. Furthermore, investors and potential investors could use the results to make future investment decisions.
An Overview of the Utilization of TikTok in Improving Young Saudi Learners’ Speaking Skills
Authors: Rshoud Aldossari Albandari Turki
Published: May 2024

The present study sought to examine the effectiveness of social media applications, particularly the TikTok platform, in the improvement of English-speaking skills among young Saudi learners from the perspectives of both learners and teachers. The study attempted to answer three questions: How far is the use of social media, especially TikTok, via mobile devices, effective in improving young Saudi learners’ speaking skills outside the classroom? What are young Saudi English language learners’ perspectives on the use of TikTok via mobile devices as a tool for improving their speaking skills? To what extent is learning to speak English through TikTok more effective than traditional class methods? The researcher used a mixed-methods approach to collect data in the study. The sample consisted of 120 secondary school and university students who participated in the study. To reach valid conclusions regarding their perceptions on the use of TikTok as a language development tool, the participants responded to an online 5-point Likert scale questionnaire. Following that step, three experienced English teachers provided their perceptions of the impact of TikTok as an enhancement tool in English-speaking learning. The findings of the study indicated that TikTok is an effective tool for learning English, particularly in relation to speaking skills, since both most young Saudi learners and teachers agreed that they perceive TikTok as an effective learning tool that English learners can utilize to motivate them and enhance their speaking skills.
Efikasi diri dalam pengasuhan ditinjau dari struktur keluarga
Authors: Pratiwi Pradipta Christy , Yustitia Hani Chandra
Published: May 2024

Efikasi diri dalam pengasuhan dibutuhkan orang tua agar peran dan tanggung jawab sebagai orang tua dapat dilakukan dengan optimal. Faktor kuat yang terkait dengan efikasi diri dalam pengasuhan adalah struktur keluarga. Penelitian ini bertujuan untuk mengetahui perbedaan efikasi diri dalam pengasuhan ibu dari keluarga batih dan keluarga besar. Sampel yang diperoleh sebanyak 149 ibu yang diperoleh melalui teknik aksidental, di mana 88 partisipan di antaranya dari keluarga batih. Partisipan diminta mengisi Skala Parenting Self-Efficacy. Hasil menunjukkan efikasi diri dalam pengasuhan ibu dewasa awal dari keluarga batih lebih tinggi daripada ibu dewasa awal dari keluarga besar. Studi ini menekankan bahwa ibu usia dewasa awal pada keluarga batih mampu memberikan lingkungan belajar yang nyaman dan penerapan aturan yang lebih konsisten dalam pengasuhan dibandingkan ibu usia dewasa awal pada keluarga besar.
Emergency Nursing Didactics – Opinions, Resource, and Skill Exchange (E.N.D.O.R.S.E) – A collaborative academic initiative in the Emergency Department
Authors: Rehman Mohammad , Salih Elrasheed , Mathew Honey , Abdulrahman Ramna , Chahla Ahmad , Prasad Rishi
Published: May 2024

Introduction: Emergency Physicians and Nurses often work together as the two most prominent figures at the patient bedside, involved in clinical decision making, procedures, and medication administration. However, they are not afforded many opportunities to debrief and share educational knowledge and resources surrounding decisions, implementation, and protocols. After preliminary discussions on interest and knowledge gaps, a collaboration between Emergency Physicians and nurses was established under an academic initiative entitled ‘Emergency Nursing Didactics – Opinions, Resource, and Skill Exchange (E.N.D.O.R.S.E.)' at Mediclinic City Hospital, Dubai.
Aims/Objectives: We aimed to provide a platform within the Emergency Department (ED) to promote interpersonal communication and feedback between healthcare providers. The initiative sought to improve skills, confidence, and standardize workflows around essential procedures/protocols.
Materials/Methods: A structured 30-minute session break-down was created and customized information handouts were prepared, with evidence-based references. Sessions were conducted once a month, with in-person teaching within the ED alongside a video conference set up.
Post-session questionnaires were utilized to determine knowledge reception, ideas on improvement, and future direction of E.N.D.O.R.S.E. sessions.
Results: Topics included waveform capnography, Inotropes and infusion settings, SVT management, Right/posterior ECG placement, high-risk pattern recognition, and Intubation workflow. Sessions lasted 30 minutes, did not interfere with actual patient care, and were attended in-person, online, with recordings viewed later by all department members. Post-session questionnaires revealed that 92.3% of participants found the sessions provided them with new information, with approximately 88% of them ‘Very confident' (5/5) in using the skills taught thereafter. 77% of participants rated the quality of the sessions as ‘Excellent' (5/5), and 88% indicated they would like for the topics to be repeated in future sessions. Participants also reported that sessions offered them a safe, structured environment within which to ask questions and improve knowledge.
Discussion: Creation of a safe, structured learning environment allows ED healthcare providers to identify knowledge and skill gaps that may otherwise not be unmasked. While Nursing education is ubiquitous, this is often delivered amongst nurses and by nurses. E.N.D.O.R.S.E. is a first-of-its-kind platform where physicians and nurses work together to develop soft skills. What seemed to be trivial tasks became optimized through collaborative learning and idea exchange.
Conclusion: Collaborative learning allows for ‘practiced proficiency' of skills and offers an opportunity to enhance ED workflow and patient care.
Consistent efficacy and safety of sublingual immunotherapy tablets across allergens and geographic regions
Authors: Stranzl Thomas , Bernstein David I. , Matsuoka Tomokazu , Durham Stephen , Maekawa Yuriko , Sejer Andersen Peter , Nolte Josephine , Hulstrom Veronica , Nolte Hendrik
Published: May 2024

Background: The clinical development program of the SQ grass, ragweed, tree, and house dust mite (HDM) sublingual immunotherapy (SLIT)-tablets for allergic rhinitis/conjunctivitis (AR/C) included clinical trials conducted in North America, Europe, and Japan. Objective:
Data from these trials were analyzed to assess efficacy, immunologic mechanisms, and safety outcomes across allergens and geographic regions. Methods: Thirteen phase III, double-blind, placebo controlled trials in the subjects with AR/C were conducted in North America,
Europe (including Russia), and Japan (N = 7763 analyzed). Trials were generally similar with respect to medical practice, target population, eligibility criteria, and efficacy and safety monitoring. Data were analyzed for the approved doses in North America and Europe. Four statistical models
were used to enhance comparison of the efficacy end points among the trials. Results: The SLIT-tablets demonstrated consistent efficacy across allergens and regions, regardless of the statistical analysis used. Relative improvement in the primary efficacy end point compared
with placebo by using the predefined protocol analysis ranged from 17.9% to 32.8%, 17.5% to 19.3%, 20.6% to 38.3%, and 39.6% with the grass, HDM, ragweed, and tree SLIT-tablets, respectively. The kinetics of specific immunoglobulin E (IgE) and IgG4 responses were similar among the allergens
and regions. Local application-site reactions were the most common adverse events for all allergens and in all regions. Most treatment-related adverse events for all allergens and in all regions were mild in severity. The rate of systemic allergic reactions was similar across regions (0%‐0.54%).
Conclusion: Confirmatory phase III trials for SLIT-tablets in the treatment of AR/C showed consistent efficacy, immunologic, and safety outcomes across allergens and geographic regions.
Survey of tenuipalpid mites (Acariformes: Tenuipalpidae) in orchid species with the presence of Cilevirus in Colombia
Authors: Montes-Rodríguez José Mauricio , Sierra Monroy Janeth Alexandra , León Martínez Guillermo Adolfo , Tassi Aline Daniele
Published: May 2024

To understand and manage viruses causing citrus leprosis it is necessary to identify their alternate host plants and know their distributions. Currently, the citrus leprosis disease is associated with several viruses of the genera Cilevirus and Dichoravirus. In Colombia, symptoms of citrus leprosis have been related to citrus leprosis virus C (CiLV-C - Cilevirus leprosis) and citrus leprosis virus C2 (CiLV-C2 - Cilevirus colombiaense). To detect leprosis-associated viruses in plants of the family Orchidaceae and identify the possible associated vectors, inspections and samplings were carried out on garden plants and orchid crops, and molecular detection of viruses and the taxonomic identification of mites were accomplished. As a result, Brevipalpus californicus s. l., B. phoenicis s.s., and B. essigi (Prostigmata: Tenuipalpidae) are recorded for the first time on orchid plants from Colombia. A taxonomic key is provided to identify mites of the family Tenuipalpidae on orchids worldwide. The implications of these mites for the phytosanitary protection in citrus crops of Colombia are discussed.
فضل الذكر في تنوير السالكين وترغيب الطالبين عبد الكريم بن ولي الدين بن يوسف القره حصاري (رحمه الله) (ت1100هــ) دراسة وتحقيق وتعليق
Authors: فاتح كيلان محمد , حماده الجبوري عـــــدي جاسم
Published: May 2024

إن أشرف العلوم بعد القران هو حديث رسول الله r , وأعظم القربات الى الله بعد كتابه, هي إن يتقرب العبد بخدمة سنة النبي r , فقد هيا الله من هذه الامة رجالا من اهل العلم حفظ الله بهم السنة , ، والذي يعد من كبار الأئمة عبد الكريم بن ولي الدين في التخريج والشرح والتوضيح , فقد كان من اكثرهم تصنيفا , وكان من الأئمة الذين جمعوا بين فنون الشريعةِ الغراء ومنها علمُ الفقهِ وعلمُ الحديث وغيرها , وقد كان عبد الكريم بن ولي الدين "رحمه الله تعالى" موافق في اغلب احكامه لأئمة النقاد من العلماء , وفي هذا المقام من هذا البحث درست المخطوط للامام "رحمه الله تعالى" في الدراسة, حسب اصول البحث العلمي .
     وختاماً الصلاة والسلام على نبينا محمد " صلى الله عليه وسلم " .
الِّرضا الوظيفيِّ لدى مدرِّسي المدارسِ الحكوميَّةِ لِلْمتفوّقينَ والمتفوّقاتِ (محافظةُ صلاح الدين انموذجًا)
Authors: احمد الغنام قيس طه , أُبَيّ رعد أمال جوزيف
Published: May 2024

استهدف البحث التعرّف على الرضا الوظيفي لدى مدرسي المدارس الحكومية للمتفوقين والمتفوقات، وفقاً للمتغيرات : الجنس (ذكور- إناث)، والتخصص (علمي – إنساني)، وعدد (سنوات الخدمة).
     تألّفت عيّنة البحث الأساسية من (119) مدرسا ومدرسة اختُيروا بالطريقة العشوائية الطبقية من مدارس تربية محافظة صلاح الدين ، وبلغ عددها (4) مدارس بواقع (2) في مركز محافظة صلاح الدين  و(2) في قضاء سامراء، ثم سُحبت عيّنة منتظمة من جميع المدارس ، ولتحقيق هدف البحث اعتمد الباحثان على أداة جاهزة لقياس الرضا الوظيفي المعدّ من قبل (عباس, 2021 ) ، ومكوّن  من (22) فقرة ذات بدائل خمس (موافق بدرجة كبيرة ,موافق ,محايد , معارض ,معارض بدرجة كبيرة ) ، موزعة على (5) أبعاد ، وقد تحقّق الباحثان من الصدق الظاهري للأداة بعرضها على مجموعة خبراء مؤلفة من الأساتذة المتخصصين في العلوم التربوية والنفسية ، كما تحقّق من ثبات الأداة بطريقتين ؛ الأولى: باستخدام معادلة ألفا- كرونباخ ، والثانية بطريقة إعادة الاختبار ، إذ بلغت قيمة معامل ارتباط بيرسون. وعولجت البيانات إحصائيا باستخدام الحقيبة الإحصائية للعلوم الاجتماعية (SPSS) والتي تضمنت مجموعة من الوسائل الإحصائية منها معامل ارتباط بيرسون ، والاختبار التائي لعينة واحدة ، والاختبار التائي لعينتين مستقلتين.
فاعلية برنامج تربوي في خفض السلوك العدواني وزيادة مستوى الدافعية للتعلم عند عينة من طالبات المرحلة الثانوية
Authors: زكي  الجبوري ختام كامل
Published: May 2024

هدف البحث الحالي الى التعرف على فاعلية برنامج تربوي  في خفض السلوك العدواني وزيادة مستوى الدافعية للتعلم عند عينة من طالبات المرحلة الثانوية. وقد تكون مجتمع البحث من (120) طالبة من طالبات الصف الخامس علمي .ومن خلال تطبيق مقياس السلوك العدواني ومقياس تدني الدافعية  تم اختيار عينة البحث (20) طالبة ممن حصلن على اعلى الدرجات على مقياس السلوك العدواني ومقياس تدني الدافعية واستخدم في البحث مجموعه من الوسائل الإحصائية  الملائمة لإجراءات البحث منها الوسط الحسابي والانحراف المعياري والاختبار التائي (T -test) وقد توصل البحث الى وجود فروق ذات دلالة إحصائية بين  درجات المجموعة التجريبية والضابطة على مقياس السلوك العدواني ومقياس دافعية التعلم ولصالح المجموعة التجريبية  وهذا يدل على فاعلية البرنامج وينسجم مع نتائج بعض الدراسات ذات العلاقة  وفي ضوء ذلك قدمت بعض الاستنتاجات والتوصيات والمقترحات .
Implementation of web-based online ordering applications for MSMEs in Ciharalang Village, Ciamis Regency
Authors: Supriatman Rian Dwicahya , Sidiq Maulana , Thoyyibah Luthfiyatun , Pascima Ida Bagus Nyoman , Fitriani Rani Ligar
Published: May 2024

This community service is intended to provide solutions to the problems experienced by a partner named UMKM Usaha Laksana Mandiri (MSMEs Usaha Laksana Mandiri), namely the low marketing literacy of trade. In implementing the objectives of this community service, an instructional method is adopted which has three stages of implementation, namely 1) socialization of the use of online sales media, 2) training in making designs and packaging goods, and 3) training in inputting data on goods to be sold in the admin menu. After going through several stages, there are several positive results from the implementation of this community service, including 1) understanding the use of online marketing information technology, 2) attractive product packaging strategies, and 3) sales skills through online marketing media by UMKM Usaha Laksana Mandiri.
Is Defense a Way of Coping?
Authors: Chatterjee Ishita
Published: May 2024

Over the years, the concept of psychological adaptability has stirred the field of psychology. Researchers from personality psychology, clinical psychology, and other interrelated areas of psychology have taken a special interest in understanding the adaptive functioning within the individual that may help in healthy adjustment. One of such adaptive mechanisms was first described by Sigmund Freud under the label of defense, which had been through a lot of revisions over the years. Another concept, though stemming from a different conceptual framework, could be equally important to understand the adjustment process, which was labeled as coping. The present article aims to shed light on the various similarities and differences between both concepts despite their conceptual distancing.
Cardiovascular risk with long-term use of proton pump inhibitors: myth or reality. A review
Authors: Trukhan Dmitry I. , Filimonov Sergej N.
Published: May 2024

Proton pump inhibitors (PPIs) are the most effective drugs for treating acid-related diseases. In recent decades, the use of PPIs has increased exponentially. From gastroenterological practice, PPIs are being actively introduced into other specialties, in particular in cardiology and rheumatology, where they are used to protect the mucous membrane of the gastrointestinal tract and prevent gastrointestinal bleeding during long-term antithrombotic therapy and long-term use of non-steroidal anti-inflammatory drugs. For a long time, PPIs were considered completely safe drugs for both short-term and long-term use. However, modern clinical guidelines note that when prescribing PPIs in large doses for a long period, the possibility of side effects should be taken into account. In recent years, a number of foreign reviews have been published that examine the relationship between PPIs and a number of diseases/conditions, including the question of a possible association of PPI use with an increased risk of cardiovascular complications, but note the inconsistency of these data. We searched the PubMed and Scopus information databases for publications on the safety of PPI use, including sources up to 12/01/2023. In this review, we examined the possible cardiovascular risk of long-term use of PPIs. Analysis of publications, despite a number of contradictions, allows us to conclude that the cardiovascular risk with long-term use of PPIs is real and must be taken into account when prescribing PPIs for a long period and to comorbid/multimorbid patients.
Ultrasound-assisted intravascular therapy: history and future perspectives of development. A review
Authors: Analeev Anton I. , Semitko Sergey P. , Chernysheva Irina E. , Belikov Nikita V. , Khaydukova Irina V. , Borde Anna S. , Ioseliani David G. , Timashev Peter S. , Fomin Victor V.
Published: May 2024

The first use of ultrasound in treating vascular disorders dates back to 1976. Since then, numerous original studies have been published, offering various concepts of its use. Many technical solutions have been developed and used with variable success, some of which have been developed in modern medicine. This article discusses the development of ultrasound therapeutic technologies in treating vascular disorders. The history of methods is described, available data on promising future areas are presented, and information on existing methods and devices is given.
Possibilities of noninvasive diagnostics of cardiovascular diseases associated with atherosclerosis
Authors: Salyamova Lyudmila I. , Pavlenko Ksenia I. , Khromova Angelina A. , Oleynikov Valentin E.
Published: May 2024

Background. Despite the global trend towards a decrease in mortality from cardiovascular pathology of atherosclerotic genesis, this group of diseases continues to occupy a leading position in the structure of disability and mortality among the population of many countries.
Aim. Identification of noninvasive markers of arterial wall lesions associated with the presence of arterial hypertension (AH) and coronary heart disease (CHD) in persons younger than 55 years.
Materials and methods. The study included 81 people. Three groups were distinguished from them: 1st (n=31) – a control group of practically healthy individuals, average age – 43 (40; 48) years; 2nd group (n=21) – patients with coronary heart disease without a history of cardiovascular diseases (CVD), average age – 45,5±6,1; group 3 (n=29) – patients with AH without CHD, average age – 47 (35; 50) years. The parameters of a biochemical blood test were determined, volumetric sphygmography and a sample with post-occlusive reactive hyperemia were performed.
Results. In groups of patients with CHD and AH, negative changes in the lipid profile and higher glucose levels were recorded compared to healthy individuals. According to the results of volumetric sphygmography, the pulse wave velocity in arteries of predominantly elastic type (R/L-PWV) in group 1 was 10.1±1.7 m/s, in group 2 – 12.9±1.8 m/s, in group 3 – 13.1 (12; 14) m/s (р1–2=0.029; р1–30.001); cardio-ankle vascular index (CAVI) – 6.5±0.7, 7.7 (7; 8.7) and 7.8 (7.3; 8.4), respectively (р1–20.001; р1–30.001). According to the data of the test with post-occlusive reactive hyperemia, a comparably high frequency of pathological values of flow-dependent vasodilation (FDV) and reactivity index (RI) was demonstrated in patients with CHD and AH (р1–20.05; р1–30.05). A multifactorial model of noninvasive diagnosis of CHD in individuals without a history of CVD, including non-high-density lipoprotein cholesterol, R/L-PWV, and FDV, has been developed. For patients with AH, glucose, lipid metabolism, R/L-PWV, pulse wave velocity in muscle-type arteries (B-PWV), augmentation index (AI), biological age, CAVI, FDV, RI were the risk factors for the presence of the disease in the anamnesis.
Conclusion. The results obtained confirm the importance of an integrated approach in the screening diagnosis of CVD.
Atherosclerosis and inflammation: Current therapeutic strategies. A review
Authors: Zubareva Marina Yu. , Sergienko Igor V.
Published: May 2024

Atherosclerosis is a chronic condition that is the main underlying cause of cardiovascular disease. Inflammation is one of the key factors in the pathogenesis of atherosclerosis and its complications. This review explains an up-to-date understanding of the immunological mechanisms of atherogenesis and biomarkers of inflammation, as well as available treatments for low-intensity chronic inflammation. Information is provided on the perspective directions of anti-inflammatory therapy for atherosclerosis being studied.
Differential diagnosis of amiodarone-induced thyrotoxicosis in a patient with atrial fibrillation and agranulocytosis on the background of thyrostatic therapy. Case report
Authors: Zherebchikova Kristina Yu. , Bubnov Dmitry S. , Ermolaeva Alexandra S. , Soltakhanova Madina O. , Sych Yulia P. , Ezhov Marat V. , Fadeev Valentin V.
Published: May 2024

Atrial fibrillation is the most common heart rhythm disorder in patients with chronic heart failure. One of the most effective antiarrhythmic drugs for the treatment and prevention of a wide range of supraventricular and ventricular tachyarrhythmia is amiodarone. In the group of patients with paroxysmal atrial fibrillation and low left ventricular ejection fraction, it is the drug of choice when conducting a „rhythm control“ strategy. Patients receiving amiodarone often develop an adverse event – amiodarone-induced thyrotoxicosis, which exacerbates the course of cardiovascular pathology. In this article, we consider a clinical case of amiodarone-induced thyrotoxicosis in a 30-year-old patient with dilated cardiomyopathy and agranulocytosis that developed against the background of thyrostatic therapy.
Correction of hyperphosphatemia in a patient with end-stage chronic kidney disease and a complex case of anemia. A clinical case
Authors: Fomin Victor V.
Published: May 2024

Iron supplements and/or blood transfusions in combination with recombinant human erythropoietin injections are routinely used to correct renal anemia, which is a common complication of end-stage renal disease. However, massive blood transfusions and inadequate intravenous iron supplementation can lead to iron overload syndrome, and anemia is not always nephrogenic. A rare clinical case of a patient with end-stage chronic kidney disease with complex genesis of anemia, who is on hemodialysis, is presented. The case is interesting because the prescription of first-line drugs was life-threatening in nature, and sevelamer was the drug chosen for the correction of mineral-bone disorders.
PERUNDUNGAN SIBER SEBAGAI PRAKTIK KEJAHATAN BERBAHASA DALAM AKUN INSTAGRAM PUAN MAHARANI
Authors: Eliya Ixsir , Santoso Anang , Taufiqurrahman Febri
Published: May 2024

Cyberbullying can be experienced by anyone, including one Indonesian female politician, namely Puan Maharani. This study aims to describe the forms and patterns of cyberbullying as a practice of language crimes against Puan Maharani on Instagram and to describe the legal potential for cyberbullying. This research uses a qualitative approach with a forensic linguistic. The data were collected using documentation technique and analyzed using Milles & Huberman analysis model on the utterances indicated to contain language crime practices. The results of the study show that in the accounts of Indonesian female politicians, namely Puan Maharani, there are comments that contain cyberbullying as a practice of language crimes. The forms of   bullying are flaming, harassment, and denigration. The cyberbullying carried out by netizens, even though it contains elements of insult and defamation, cannot be prosecuted. This is because bullying on social media is a complaint offense so if a party feels aggrieved and reports it to the police, then the case can be legally processed.Perundungan siber dapat dialami oleh siapa saja, termasuk salah satu politikus perempuan Indonesia, Puan Maharani. Penelitian ini bertujuan untuk mendeskripsikan bentuk dan pola perundungan siber sebagai praktik kejahatan berbahasa terhadap Puan Maharani di Instagram serta mendeskripsikan potensi hukumnya. Penelitian ini menggunakan pendekatan kualitatif dengan ancangan linguistik forensik. Data dikumpulkan dengan teknik dokumentasi dan dianalisis dengan model analisis Milles & Huberman pada tuturan yang terindikasi mengandung praktik kejahatan berbahasa. Hasil penelitian menunjukkan bahwa dalam akun Puan Maharani terdapat komentar-komentar yang mengandung perundungan siber sebagai praktik kejahatan berbahasa. Bentuk perundungannyanya berupa flaming, harassment, dan denigration. Perundungan siber yang dilakukan oleh warganet tersebut walaupun mengandung unsur penghinaan dan pencemaran nama baik, tetapi tidak dapat diproses hukum. Hal ini dikarenakan perundungan di media sosial merupakan delik aduan sehingga apabila ada pihak yang merasa dirugikan dan melapor kepada polisi, baru kasus tersebut dapat diproses secara hukum.
EKSPLOITASI BUNYI BAHASA PADA SUSASTRA RANGGAWAR-SITA SEBAGAI CITRA PEMIKIRAN MASYARAKAT JAWA
Authors: Nurnaningsih NFN , Wibowo Prasetyo Adi Wisnu
Published: May 2024

The unique use of language sounds adorns Raden Ngabei Ranggawarsit's literature. The purpose of this research is to find and describe the reflection of the mindset of the Javanese people which is hidden in the peculiarities of exploiting the sounds of language contained in Ranggawarsita's creations. The theory used in this research includes stylistics, language style, diction, physical structure and inner structure of poetry and rhyme/purwakanthi. This research includes descriptive qualitative research. The data of this research uses the data about language, such as words, phrases, sentences or larik (arrays) of words related to distinctive sounds in Ranggawarsita's Literature. The data source in this research are four Javanese literary libraries entitled Jaka Lodhang, Kalatidha, Sabdatama, and Serat Sabdajati. Data collection was carried out    using content analysis techniques. The data analysis technique used was data reduction, data presentation and then conclusions were drawn. The result of this research is the distinctive style of language sound exploitation in Ranggawarsita's literature is an image of Ranggawarsita's mindset or point of view towards the Javanese society towards God the Creator of the world and its contents. The expression that is hidden in the use of language actually reflects local wisdom, mindset, perspective of the life of the Javanese people towards the Supreme Creator (God) as well as the universe (the world of microcosm and macrocosm).Keunikan pemanfaatan bunyi-bunyi bahasa menghiasi susastra Raden Ngabei Ranggawarsita. Tujuan penelitian ini untuk menemukan serta memerikan cerminan pola pikir masyarakat Jawa yang tersembunyi pada kekhasan eksploitasi bunyi-bunyi bahasa yang termuat di serat-serat ciptaan Ranggawarsita. Teori yang dipakai dalam penelitian meliputi stilistika, gaya bahasa, diksi, struktur fisik dan struktur batin puisi dan rima/purwakanthi. Penelitian ini termasuk penelitian kualitatif deskriptif. Data penelitian menggunakan data kebahasaan, seperti kata-kata, frasa, kalimat atau larik kata yang berkaitan dengan bunyi-bunyi yang khas di dalam serat hasil kreasi pikir Ranggawarsita. Sumber data penelitian yaitu empat pustaka susastra berbahasa Jawa berjudul Jaka Lodhang, Kalatidha, Sabdatama, dan Sabdajati. Pengumpulan berbagai data dilakukan dengan teknik content analysis. Teknik analisis data yang digunakan meliputi mereduksi setiap temuan data, membuat penyajian setiap data, dan menyajikan simpulan yang diperoleh. Hasil penelitian menunjukkan bahwa kemenarikan style setiap eksploitasi satuan kemerduan bunyi kata di dalam karya hasil kreatif Ranggawarsita merupakan citra pola pikir atau kaca pandang Ranggawarsita sebagai orang Jawa kepada Tuhan Pencipta dunia beserta isinya. Ekspresi yang tersembunyi pada pendayagunaan bahasa sebenarnya mencerminkan kearifan lokal, pola pikir, kaca pandang hidup suku bangsa Jawa kepada Khaliqnya juga alam semesta (dunia alam raya seisinya maupun diri pribadi).