bluuebunny/crossref_metadata_2025 huggingface dataset:
A new hybrid fuzzy bio-inspired classifier for cancer detection using cuckoo optimization and hyper-planes
Authors: Abdolrazzagh-Nezhad Majid , Izadpanah Shaghayegh
Published: February 2025

Purpose

Various methods are used for cancer detection such as genetic tests, scanning, MRI, mammography, etc. These methods help collect data on patients, which can be utilized for comparing a new patient’s information with the aggregated data to detect cancer. The main step in this process is data classification. There are several cancer detection methods with their own disadvantages in flexibility, non-linear complexity and sensitive in imbalance data. In this paper, a new fuzzy bio-inspired based classification method is designed to classify the imbalance medical data.

Design/methodology/approach

In this paper, a new fuzzy bio-inspired-based classification method is designed to classify the imbalance of medical data. The method consists of a new fuzzy draft of the Cuckoo Optimization Algorithm (COA) and separating hyper-planes based on assigning binary codes to separated regions that are called Hyper-Planes Classifier (HPC). Based on the technical review is done in the paper, the HPC has a better structural superiority than the other classification algorithms. The Fuzzy Cuckoo Optimization Algorithm (FCOA), which fills up its challenge in proper tuning parameters, is proposed to optimize the weights of the separating hyper-planes with linear complexity time.

Findings

The experimental results were presented in five steps. Step1, the details of the average and the best results of the proposed methods were reported and compared. Step2, the quality of the detection methods with different numbers of hyper-planes were compared. The obtained weights of different numbers of hyper-planes were reported in Step3. Step4, the convergence process of the FCOA and the COA were shown. Step5, the best obtained results were compared with the best reported one in previous literature. The experimental results and the presented comparisons show that the proposed hybrid detection method is comparable to other methods and operates better than them in most cases.

Originality/value

A technical review has been done based on classifying the applied classification methods to cancer detection and analyzing advantages (+) and disadvantages (−) of the methods and their optimizer algorithms. A new fuzzy draft of COA has been designed to dynamically tuning the Egg Laying Radius based on a fuzzy inference system with four fuzzy rules. A novel hybridization of the hyper-planes classification method and the designed FCOA has been proposed to optimize the hyper-planes' weights. The effectiveness of the proposed hybridization has been examined in famous UCI cancer datasets based on one, two, three and four hyper-planes and compared with more than 30 previous researches.
Ambulance personnel’s intention to quit and its associations: a multi-group comparison using structural equation modelling
Authors: Dao-Tran Tiet-Hanh , Townsend Keith , Loundoun Rebecca , Wilkinson Adrian , Seib Charrlotte
Published: February 2025

Purpose

This study aims to explore the intention to quit and its associations among ambulance personnel and to compare the intention to quit and its associations between paramedic and non-paramedic staff.

Design/methodology/approach

A cross-sectional study was conducted on 492 Australian ambulance personnel. Participants were selected by stratified random sampling. Data were collected using phone interview-administered questionnaires. Descriptive analyses, bivariate associations and structural equation modelling were performed for data analysis.

Findings

The study found that 70% of ambulance personnel intended to quit their jobs. Intention to quit was similar between paramedics and non-paramedic staff. In both staff groups, supervisors' and colleagues' support was associated with mental health symptoms; job satisfaction was associated with the intention to quit. Supervisors' and colleagues' support was indirectly associated with the intention to quit via increasing job satisfaction and reducing the experience of mental health symptoms among paramedics only. Mental health symptoms were directly associated with the intention to quit and indirectly associated with the intention to quit via reducing job satisfaction among paramedics only.

Practical implications

The study findings provide evidence for resource allocation in human resource management. The findings suggest that interventions to increase job satisfaction may reduce the intention to quit for all ambulance personnel. Interventions to improve supervisors' and colleagues' support and to manage depression, anxiety and stress symptoms may help to reduce the intention to quit for paramedics only.

Originality/value

This is the first study to model and compare the direct and indirect associations of intention to quit between paramedics and non-paramedic staff in ambulance personnel.
Predicting post-IPO financial performance: a hybrid approach using logistic regression and decision trees
Authors: Supsermpol Pornpawee , Huynh Van Nam , Thajchayapong Suttipong , Suppakitjarak Nathridee , Chiadamrong Navee
Published: February 2025

Purpose

This study enhances the financial modelling of companies undergoing an Initial Public Offering (IPO) by focusing on internal capability determinants and IPO proceeds.

Design/methodology/approach

A hybrid logistic regression and shallow-depth decision tree approach are employed to predict the initial three-year post-IPO performance of companies listed on the Stock Exchange of Thailand (SET) using data from 2002 to 2021.

Findings

The results demonstrate that these models not only perform competitively against complex machine learning algorithms but also surpass them in terms of interpretability, an essential feature in financial modelling. The proposed approach effectively captures the effects of each determinant, offering valuable insights into strategic resource allocation and investment decision-making during transition years.

Originality/value

This study introduces a novel application that integrates logistic regression with decision trees to predict multiclass financial performance, filling the gap between complex machine learning techniques and interpretable financial models. It offers practical tools for companies and investors to make informed decisions in challenging post-IPO environments.
Climate change and Task Force on Climate-related Financial Disclosures (TCFD) reports. A comparison between Italy and Spain
Authors: Xhindole Chiara , Tarquinio Lara , Sierra-García Laura
Published: February 2025

Purpose

This study aims to analyse the reporting practices of a sample of companies listed in Italy and Spain that prepare a Task Force on Climate-related Financial Disclosures (TCFD) report. The main purpose is to analyse the reporting’s compliance with the TCFD framework and the extent of climate-related information disclosed.

Design/methodology/approach

This study performs a content and comparative analysis of climate-related information disclosed by Italian and Spanish companies listed on the FTSE MIB and IBEX-35, following the consolidated narrative interrogation (CONI) model. The analysis is carried out on 31 TCFD reports published in 2020, 2021, 2022 and 2023, using NVivo software for content analysis and information coding.

Findings

Overall, the study shows that Italian and Spanish companies comply with the TCFD framework. However, some topics, such as governance-related aspects and risk management, are disclosed differently and may merit more in-depth reporting.

Practical implications

The findings of this study are valuable for companies and their stakeholders, in particular investors. The increasing focus on mandatory climate reporting and the adoption of new climate standards are increasing the pressure on companies to manage these issues, and the results of this work already indicate which aspects of the reporting process need to be improved to meet the new information requirement.

Originality/value

This study strengthens the theoretical and empirical literature on climate change information by conducting a cross-country content analysis of TCFD reports. The results provide a basis for future analysis of climate disclosure according to the latest developments in standards and frameworks.
In the pursuit of educational excellence: investigating CSFs for implementing NEP 2020 to redefine the higher education ecosystem
Authors: Narkhede Ganesh , Pasi Bhaveshkumar , Dhamak Pallavi , Mahalle Parikshit , Ambhore Nitin
Published: February 2025

Purpose

In the ever-changing landscape of education, new policies play a very crucial role in shaping the future trajectory of nations. The National Education Policy (NEP) 2020 stands as a testament to the commitment toward redefining the educational paradigm in India. This research aims to identify the critical success factors (CSFs) and present a roadmap to facilitate the implementation of NEP 2020 in Higher Education Institutions (HEIs).

Design/methodology/approach

A dual-research method is used in this study. First, a systematic literature review was performed to identify the CSFs. Furthermore, the Technique for Order of Preference by Similarity to Ideal Solution (TOPSIS) method was implemented to rank CSFs.

Findings

The study identifies the CSFs essential for the effective implementation of NEP in Indian HEIs. A comprehensive strategic roadmap, integrating institutional theory, diffusion of innovation, and policy implementation frameworks, is proposed to guide HEIs in aligning with NEP objectives. Additionally, context-specific solutions inspired by global best practices ensure localized and inclusive implementation. The findings highlight NEP 2020s emphasis on multidisciplinary education, digital transformation, equity-driven policies, and institutional restructuring.

Practical implications

This study advances multidisciplinary education models, equity-driven policy, and technology-driven reforms. Practical insights include flexible learning pathways, multilingual education, vocational training integration, and quality assurance mechanisms, fostering innovation and global competitiveness in India’s higher education landscape.

Originality/value

This groundbreaking research identifies and prioritizes CSFs, also offers a unique strategic roadmap combining institutional and innovation theories for NEP 2020 implementation. It incorporates global best practices and context-specific solutions for transforming India’s higher education ecosystem comprehensively.
The balance of power: assessing earnings quality in the shadow of corruption in GCC countries
Authors: Persakis Antonios , Jallad Ra’fat
Published: February 2025

Purpose

This study aims to address a research gap by examining the relationship between CEO power, board strength and earnings quality in Gulf Cooperation Council (GCC) countries, a region with distinctive economic and governance characteristics. It explores how governance mechanisms impact financial reporting in a context marked by significant corruption challenges and regulatory dynamics. The paper underscores the relevance of the GCC setting because of its unique blend of rapid economic reform, policy shifts toward diversification and evolving governance frameworks influenced by Islamic principles.

Design/methodology/approach

This study uses 5,030 firm-year observations from GCC countries over the period 2003–2022. To test the study’s hypotheses, the authors apply the System Generalized Method of Moments.

Findings

The study reveals a significant negative correlation between perceived corruption and earnings quality, with higher corruption leading to lower earnings quality. It finds that CEO power further diminishes earnings quality and intensifies corruption’s negative effects on financial reporting while strong board governance positively affects earnings quality and reduces the adverse impact of corruption.

Originality/value

By focusing on the GCC – a region undergoing significant regulatory reforms and policy changes – this study enriches the discourse on earnings quality within emerging markets. It provides novel insights into how corruption, CEO power and board strength interact to influence financial reporting quality, offering actionable implications for policymakers and stakeholders navigating these unique economic and governance landscapes.
Linking business model implementation to strategy and organisational results in the Baldrige Excellence Framework: an empirical analysis
Authors: Alanazi Mohammed Hamdan
Published: February 2025

Purpose

Strategy and business models (BMs) are key to success and are increasingly used by organisations. Using the Baldrige Excellence Framework (BEF), this study mainly aims to analyse the role of BM implementation, as captured by operating model (OM) and enterprise architecture (EA), in the context of business excellence models.

Design/methodology/approach

The research model is analysed using partial least squares and survey data from 203 Saudi firms.

Findings

The findings show that the importance of BM implementation (i.e. OM and EA execution) is reinforced by the mediating effect exerted by these constructs between strategy and organisational results. In addition, this study develops a conceptual framework depicting the integration of BMs and the BEF. It also discusses the resultant implications for theory, management practice and future research.

Originality/value

In the context of business excellence models, empirical analyses on the extent to which strategy and BMs can be interrelated and integrated are scarce. This paper contributes to filling this research gap.
Assessment of older adults' decision‐making capacity for independent living: Findings from a nominal group technique meeting in Ireland
Authors: Usher Ruth , Stapleton Tadhg
Published: February 2025

Introduction

Occupational therapists are one of the nominated professions who can assess decision‐ making capacity in according to recent Irish legislation. However, the process of implementing this legislation into practice remains unclear for therapists. The aim of this study was to form a consensus on recommended procedures for occupational therapists when assessing older adults' decision‐making capacity for independent living.

Methods

A nominal group technique was employed to identify and rank critical dimensions of capacity assessment. Twenty occupational therapists from a range of Irish practice settings participated in a 1‐day consensus meeting.

Results

Key triggers indicating the need for capacity assessment related to independent living were risk, reduced insight and conflicting stakeholder perspectives on older person's needs (strong consensus). Capacity assessment should consider observations of function, cognitive assessment, and home‐based assessment (strong consensus). Strategies to maximise the older person's participation in the capacity assessment and enable occupational therapists to embed will and preference within the capacity assessment process were identified.

Conclusion

Findings represent a hierarchical organisation of key components to be considered in capacity assessment of independent living and highlight the role of occupational therapy in assessing and enhancing older adults' decision‐making capacity.

Consumer and Community Involvement

No consumers/patients of occupational therapists were involved in the study.

PLAIN LANGUAGE SUMMARY

Many older people want to stay in their own homes for as long as they can. Occupational therapists assist the person to make this decision.

This study looked at how occupational therapists in Ireland help older people make this decision. Twenty therapists agreed on the best way to check if someone can decide to live independently.

Sometimes, tests are needed because of safety risks, confusion, or family disagreements. Therapists watch how people do daily tasks, test their thinking, and check their home to help them decide. The study also suggests ways to make sure older people are included in these decisions.
Virtue as Competence: A Conceptual Integration of Competence Thinking with MacIntyrean Virtue Ethics
Authors: Moosmayer Dirk C. , Rocchi Marta , Ferrero Ignacio
Published: February 2025

Recent management education debates identify room for greater emphasis on character building within business school pedagogies. As a way forward, we suggest virtue ethics as an agent‐centred character‐building ethical approach that provides guidance in management education where norm‐ and outcome‐oriented ethical approaches have limits. However, its whole‐person and life‐span perspective makes it difficult to develop virtue ethics competence in business schools. We thus conceptualise a virtue as competence learning framework for management. We do so by integrating Alasdair MacIntyre's virtue approach with the intellectual–behavioural–personal (IBP) competence framework that specifies independent and interdependent dimensions of intellectual, behavioural and personal competence. The virtue as competence learning framework guides learners to develop virtue competence. We make three contributions. First, we explicitly address the whole‐person and life‐span perspective of virtue and thus address the lack of systematic approaches to virtue ethics learning in managerial studies. Second, by conceptually applying the IBP competence framework to the learning of a whole‐person ethics approach, we address the particularisation of competences in the competence debate. Third, we offer concrete inspirations for a character‐building pedagogy that develops whole‐person competence and addresses the scarcity of ethics pedagogies that develop behavioural and personal competence.
Establishment of a New Retinal Service in Remote Western Australia: Kimberley Hub—A Comparative Audit 2019–2022
Authors: Wiffen James , Drinkwater Jocelyn , Shah Vaibhav , Turner Angus
Published: February 2025

Background

Lions Outback Vision provides access to specialist eye care in rural and remote Western Australia. In 2020, the Kimberley Hub was established as a new regional base in Broome for outreach services in the northwest of the state. Vitreoretinal services commenced for the first time in Broome in 2021.

This is a retrospective audit of retinal services provided by Lions Outback Vision in the year prior to, and following, establishment of the Kimberley Hub.

Methods

All ophthalmology occasions of service in the Kimberley in 2019 (1/1/19–31/12/19) were compared with those from April 2021 to March 2022.

Data are presented as number (percentage) and mean ± SD as continuous data was normally distributed. Two‐way comparisons were by chi‐square test.

Results

Occasions of service increased by 75% from 3307 to 5793 between the 2019 and 2021/22 periods respectively. Nonattendance significantly reduced from 28.5% to 18.7% (p < 0.001). In the 12 months following the introduction of vitreoretinal capabilities, 42 surgeries were performed on 35 people (mean ± SD age of 56.1 ± 13.1 years at first surgery), 17 (48.6%) were male, 29 (82.9%) identified as Aboriginal or Torres Strait Islander and 19 (54.3%) had diabetes. Nine (21.4%) of these cases were emergency procedures. The number of intravitreal injections given significantly increased by 87% between 2019 and 2021/22. There were 3.5 times more laser photocoagulative procedures.

Conclusion

Establishment of the Kimberley Hub saw increased appointments, reduced nonattendance and establishment of the first vitreoretinal service in remote Western Australia.
A continuous performance management approach: Effects of daily performance management behaviors on leader‐member exchange, next‐day job attitudes, and job performance
Authors: Zhang Xiyang , Qian Jing
Published: February 2025

Building on the trend of performance management (PM) moving towards more frequent and the research gap for the effectiveness of the modern form of PM, we adopt an experience sampling method to study daily PM behaviors continuously for two weeks. Our theoretical model was tested using 906 observations from 97 full‐time employees, providing initial evidence for daily PM's effectiveness in increasing employee next‐day job attitudes and job performance. Moreover, we also revealed the relationship‐based mechanism underlying the effects of daily PM. Specifically, our findings suggest that daily PM behaviors increase employee next‐day job satisfaction, job engagement, and job performance because PM behaviors make employees perceive a higher leader‐member exchange relationship. Importantly, we found the boundary conditions for PM behaviors in increasing this exchange relationship quality. The relationship was weaker when work stressors (i.e., workload and cognitive stressors) were high rather than low. We discuss theoretical and practical implications, limitations, and future research directions.
Revisiting the relationship between career plateau and job performance: A social‐cognitive perspective
Authors: Yang Wei‐Ning , Wang Yu‐Hsuan , Doden Wiebke , Wang Pei‐Yun
Published: February 2025

Previous studies examining the influence of career plateau on job performance have primarily adopted a social exchange or conservation‐of‐resources perspective, but support for these perspectives has been inconsistent. Our research takes a novel theoretical approach by investigating how and when career plateau affects job performance through a social‐cognitive lens. Specifically, we propose job self‐efficacy as a mechanism through which hierarchical and job content plateau affect job performance, and that these relationships will be moderated by career stage. Path analysis results from a multi‐wave, multisource study featuring supervisor–subordinate dyads indicate that a hierarchical plateau (where promotions are perceived as unlikely) is associated with lower job self‐efficacy and, in turn, lower supervisor‐rated performance for employees in the maintenance career stage. In contrast, a job content plateau (where employees perceive a lack of new responsibilities and work challenges) is associated with higher job self‐efficacy and, in turn, better supervisor‐rated performance, regardless of their career stages. By applying a novel theoretical perspective, we enhance understanding of the relationship between career plateau and employee performance.
Effects of Pretreatment With Coenzyme Q10 (CoQ10) and High‐Intensity Interval Training (HIIT) on FNDC5, Irisin, and BDNF Levels, and Amyloid‐Beta (Aβ) Plaque Formation in the Hippocampus of Aβ‐Induced Alzheimer's Disease Rats
Authors: Puoyan‐Majd Samira , Parnow Abdolhossein , Rashno Masome , Heidarimoghadam Rashid , komaki Alireza
Published: February 2025

Aims

Physical exercise has been shown to protect against cognitive decline in Alzheimer's disease (AD), likely through the upregulation of brain‐derived neurotrophic factor (BDNF). Recent studies have reported that exercise activates the FNDC5/irisin pathway in the hippocampus of mice, triggering a neuroprotective gene program that includes BDNF. This study aimed to investigate the effects of 8 weeks of pretreatment with coenzyme Q10 (CoQ10) and high‐intensity interval training (HIIT), both individually and in combination, on FNDC5, irisin, BDNF, and amyloid‐beta (Aβ) plaque formation in the hippocampus of Aβ‐related AD rats.

Methods

In this study, 72 male Wistar rats were randomly assigned to one of the following groups: control, sham, HIIT (low intensity: 3 min running at 50%–60% VO2max; high intensity: 4 min running at 85%–90% VO2max), Q10 (50 mg/kg, orally administered), Q10 + HIIT, AD, AD + HIIT, AD + Q10, and AD + Q10 + HIIT.

Results

Aβ injection resulted in a trend toward decreased levels of FNDC5, irisin, and BDNF, alongside increased Aβ plaque formation in the hippocampus of Aβ‐induced AD rats. However, pretreatment with CoQ10, HIIT, or their combination significantly restored hippocampal levels of FNDC5, irisin, and BDNF, while also inhibiting Aβ plaque accumulation in these rats.

Conclusion

Pretreatment with CoQ10 and HIIT improved the Aβ‐induced reduction in BDNF levels probably through the FNDC5/irisin pathway and preventing Aβ plaque formation.
NFAT1 Signaling Contributes to Bone Cancer Pain by Regulating IL‐18 Expression in Spinal Microglia
Authors: Chen Xuetai , Zeng Ying , Wang Zizhu , Zhu Jixiang , Liu Fengyun , Zhu Mingxuan , Zheng Jiayi , Chen Qingdaiyao , Zhai Dongxu , Chen Yangyang , Niu Jiayao , Xue Zhouya , Sun Guan , Li Feng , Pan Zhiqiang
Published: February 2025

Aims

This study aimed to test the hypothesis that nuclear factor of activated T cells 1 (NFAT1) signaling contributes to bone cancer pain by regulating interleukin (IL)‐18 expression in spinal microglia.

Methods

This study was performed on male mice using a Lewis lung carcinoma‐induced bone cancer pain model. Nociceptive behaviors were evaluated by measuring mechanical allodynia, thermal hyperalgesia, and spontaneous pain. Expression levels were measured via real‐time quantitative polymerase chain reaction, western blotting, and immunofluorescence analysis. The effect of pharmacologic intervention of spinal NFAT1/IL‐18 signaling on bone cancer pain was the primary outcome.

Results

NFAT1 expression was upregulated in the spinal microglia after tumor inoculation. Pharmacological inhibition of NFAT1 upregulation prevented and reversed bone cancer‐related pain behaviors. In spinal microglia, NFAT1 inhibition decreased p38 MAPK phosphorylation and IL‐18 production. Blocking NFAT1 signaling suppressed tumor‐induced neuronal sensitization and microglial activation as well as activation of the N‐methyl‐D‐aspartate receptor and the subsequent Ca2+‐dependent signaling.

Conclusion

Microglia NFAT1‐p38 signaling contributes to bone cancer pain through IL‐18‐mediated central sensitization in spinal microglia. NFAT1 could be a potential target for therapeutic intervention to prevent bone cancer pain.
Panaxadiol Attenuates Neuronal Oxidative Stress and Apoptosis in Cerebral Ischemia/Reperfusion Injury via Regulation of the JAK3/STAT3/HIF‐1α Signaling Pathway
Authors: Zhou Jiabin , Lei Yu , Zhang Shilin , Liu Yuhan , Yi Dongye
Published: February 2025

Background

Cerebral ischemic stroke (CIS) is a debilitating neurological condition lacking specific treatments. Cerebral ischemia/reperfusion injury (CIRI) is a critical pathological process in CIS.

Purpose

This study aimed to explore the protective effects of panaxadiol (PD) against oxidative stress‐induced neuronal apoptosis in CIS/CIRI and its underlying mechanisms.

Method

An MCAO mouse model was established to investigate the therapeutic effects of PD in vivo. Network pharmacology and molecular docking techniques were used to predict PD's anti‐CIS targets. The protective effects of PD were further validated in vitro using oxygen–glucose deprivation/reoxygenation (OGD/R)‐treated HT22 cells. Finally, core targets were verified through combined in vivo and in vitro experiments to elucidate the mechanisms of PD in treating CIS.

Result

PD exhibited significant neuroprotective activity, demonstrated by restoration of behavioral performance, reduced infarct volume, and decreased neuronal apoptosis in mice. Network pharmacology analysis identified 24 overlapping target genes between PD and CIS‐related targets. The hub genes, PTGS2, SERPINE1, ICAM‐1, STAT3, MMP3, HMOX1, and NOS3, were associated with the HIF‐1α pathway, which may play a crucial role in PD's anti‐CIS effects. Molecular docking confirmed the stable binding of PD to these hub genes. Both in vitro and in vivo experiments further confirmed that PD significantly mitigates neuronal apoptosis and oxidative stress induced by CIS/CIRI.

Conclusion

PD significantly counteracts CIS/CIRI by modulating the JAK3/STAT3/HIF‐1α signaling pathway, making it a promising therapeutic agent for treating CIS/CIRI.
Treatment‐Free Remission Outcomes in a BCR::ABL1 Digital PCR Selected Clinical Cohort of CML Patients
Authors: Kockerols C. , Valk P. J. M. , Hogenbirk P. , Geelen I. , Blijlevens N. M. A. , Janssen J. J. W. M. , Hoogendoorn M. , Kersting S. , Klein S. K. , Daenen L. G. M. , Donker M. , te Boekhorst P. A. W. , Jie K.‐S. G. , Corsten M. , Cruijsen M. J. , Levenga H. , Smit W. M. , Levin M.‐D. , de Jongh E. , de Jonge S. , Vlot A. J. , Durian M. F. , Zwaginga J. J. , Mohlmann M. , Wustman T. J. , Blommers R. , Cornelissen J. J. , Westerweel P. E. ,   Collaborating Authors
Published: February 2025

Approximately 40%–60% of patients reaching a stable deep molecular response during TKI treatment will maintain a state of remission after TKI discontinuation, denoted as treatment‐free remission (TFR). Depth of molecular response assessed by BCR::ABL1 digital PCR prior to TKI discontinuation has demonstrated its significance as a reliable predictive parameter for TFR. A clinically applicable prediction cutoff of 0.0023%IS has been established and externally validated. In this study, BCR::ABL1 digital PCR, as most sensitive and stable assay of its kind, was investigated as a TFR prediction tool in the Netherlands, and evaluated for its predictive value to stop TKI treatment below the aforementioned cutoff. The primary endpoint of molecular recurrence (MolR, BCR::ABL1 > 0.1%IS) at 12 months was prospectively assessed. Overall, 67 discontinued patients below the set BCR::ABL1 digital PCR cutoff were included. The overall MolR probability was 50% (95% CI, 36%–62%). In 38 patients treated for more than 6 years as commonly recommended as desirable treatment duration before TFR attempt, the MolR probability dropped to 36% (95% CI, 18%–50%). Patients attempting an early TKI discontinuation (treated for less than 6 years) had a high MolR probability of 76% (95% CI, 65%–89%). BCR::ABL1 digital PCR was successfully used in Dutch clinical practice. Our study indicates that in patients with a low BCR::ABL1 digital PCR result, a total TKI treatment duration of six or more years remains associated with a lower MolR rate and should generally be pursued. In patients treated for more than 6 years, BCR::ABL1 digital PCR was capable to identify stop candidates with a higher probability of TFR success.
Conflict and Father Involvement: The Unique Role of Postpartum Destructiveness for Fathers' Direct Care in Toddlerhood
Authors: Murray‐Perdue Samantha A. , Rayburn Stephanie , Wang Lijuan , Cummings E. Mark , Braungart‐Rieker Julia M.
Published: February 2025

Father involvement in childcare is associated with positive outcomes for children. Growing evidence supports many predictors of fathers' involvement, including maternal gatekeeping and father characteristics. The present study focuses on fathers' postpartum experiences, exploring parallel insights from environmental, interpersonal, and internal factors after having a baby to predict later involvement. We investigated how early household chaos, couple conflict, and father depressive symptoms in infancy predict later direct involvement in toddler care. The current study utilized data from 202 families participating in a parenting intervention program. We longitudinally assessed father reports of household chaos and their depressive symptoms, and employed an observational measure of conflict, at 6, 12, and 18 months postpartum to predict mother and father reports of father direct contributions to childcare at 18 months. Latent variables were created for household chaos, depressive symptoms, and destructiveness to incorporate reports 6 months apart. A structural equation model indicated father appraisals of household chaos were positively associated with depressive symptoms over time. Furthermore, couple destructiveness was negatively predictive of mothers' reports, but not fathers' reports of father direct care at 18 months after controlling for direct care behavior within 6 months postpartum. These results suggest that although father appraisals of his environment likely relate to his mental health, couple functioning played a greater role over time in direct care. We emphasize including fathers' appraisals of their experience in future research and underscore the potential impact of intervening at the couple level postpartum to support fathers' direct involvement in childcare over time.
Reinforcing the Significance of Crop Diversity for Biodiversity Conservation in the Face of Agricultural Expansion
Authors: Guerrero Irene , Morales Manuel B.
Published: February 2025

This comment about the global impact of agriculture on biodiversity in relation to eco‐regions and crop types highlights the divergent responses of tropical and non‐tropical ecosystems in their response to agricultural transformation due to ecological, climatic and historical factors. Authors emphasise the importance of management intensity and crop diversification in modulating that impact, as well as the need to preserve singular biological communities adapted to the extensively managed agro‐ecosystems of subtropical and temperate regions of the world.
Climate‐Influenced Ecological Memory Modulates Microbial Responses to Soil Moisture
Authors: Liang Shuxin , Zhu Wenjin , Zhang Weihong , Geng Jun , Grossart Hans‐Peter , Fang Linchuan , Shi Yu , Yang Yuyi
Published: February 2025

Long‐term climatic differences shape the ecological memory of soil bacterial communities, which refers to the ability of past events to influence current environmental responses. However, their ecological mechanisms and consequences for bacterial responses to current environmental changes remain largely unknown, particularly in terms of temporal dynamics. Therefore, soil bacterial communities in the arid (Lhasa River Basin) and humid (Nyang River Basin) grasslands of the Qinghai‐Tibet Plateau were compared to explore their temporal dynamics in response to current soil moisture and the resulting ecological consequences. Our results indicate that the differences between current and historical soil moisture determine the degree of divergence in bacterial community composition and potential function. The temporal dynamics of bacterial community composition, life strategies, and potential functions differed with environmental history, even under comparable moisture conditions. In contrast, bacterial communities with the same environmental history exhibited similar temporal dynamics, suggesting that environmental history has an important influence on bacterial community dynamics. This phenomenon may be caused by the continuous accumulation of bacterial community life strategies as an informational legacy, regulating future response patterns to soil moisture changes and thereby affecting biogeochemical cycles in the soil. For example, soil bacterial communities in relatively arid regions may increase their potential for dormancy, even when the current soil environment is moist, thereby enhancing ecosystem resilience by improving their capacity to respond to future drought events. This study provides new insights into the ecological memory of soil bacteria, emphasizing its critical role in influencing the compositional and functional changes of bacterial communities in response to current environmental changes. It highlights the significance of understanding the effect of environmental history in predicting the future responses of bacterial communities to disturbances and environmental changes.
The Depletion of TRAIP Results in the Retention of PCNA on Chromatin During Mitosis Leads to Inhibiting DNA Replication Initiation
Authors: Shiomi Yasushi , Hayashi Akiyo , Saito Yuichiro , Kanemaki Masato T. , Nishitani Hideo
Published: February 2025

Loading PCNA onto chromatin is a pivotal step in DNA replication, cell cycle progression, and genome integrity. Conversely, unloading PCNA from chromatin is equally crucial for maintaining genome stability. Cells deficient in the PCNA unloader ATAD5‐RFC exhibit elevated levels of chromatin‐bound PCNA during S phase, but still show dissociation of PCNA from chromatin in mitosis. In this study, we found that depletion of TRAIP, an E3 ubiquitin ligase, results in the retention of PCNA on chromatin during mitosis. Although TRAIP‐depleted cells with chromatin‐bound PCNA during mitosis progressed into the subsequent G1 phase, they displayed reduced levels of Cdt1, a key replication licensing factor, and impaired S phase entry. In addition, TRAIP‐depleted cells exhibited delayed S phase progression. These results suggest that TRAIP functions independently of ATAD5‐RFC in removing PCNA from chromatin. Furthermore, TRAIP appears to be essential for precise pre‐replication complexes (pre‐RCs) formation necessary for faithful initiation of DNA replication and S phase progression.
Public Stigma of Stroke Scale: Turkish Validity and Reliability Study
Authors: Turan Gülcan Bahcecioglu , Özer Zülfinaz , Yıldız Esra
Published: February 2025

Objective

This study was conducted to examine the validity and reliability of the Turkish version of the Public Stigma of Stroke Scale (PSSS).

Background

The stigma perceived by patients who have had stroke affects the quality of life as well as many health‐related factors. Therefore, it is necessary to determine the society's stigmatization of the stroke patient and to reveal the differences related to stroke in different cultures.

Design

This study is methodological research.

Methods

This study was conducted with 410 individuals aged 18 and over. The data were collected by using descriptive information form and PSSS. The data were evaluated by using exploratory and confirmatory factor analysis, Cronbach's alpha, McDonald's Omega reliability, composite reliability, mean variance extracted and test–retest analysis.

Results

Factor load values of the scale items were found to vary between 0.585 and 0.904. The fit index values in the scale were found as X2/df = 2.42, < 0.001, CFI = 0.934, TLI = 0.928, SRMR = 0.042 and RMSEA = 0.059. It was found that Cronbach's alpha coefficients of the factors of the scale ranged between 0.916 and 0.946, and the total Cronbach's alpha coefficient was 0.897. Total McDonald's omega coefficient was found to be 0.897, and McDonald's omega coefficients of the factors were found to be between 0.921 and 0.951. Total composite reliability was found to be 0.981, and total mean variance extracted was found to be 0.740. It was found that the Turkish version of the 33‐item and four‐factor scales was confirmed without any changes in the original scale form.

Conclusion

Turkish version of PSSS is a valid and reliable measurement tool for the evaluation of the stigmatization of stroke patients by the public and for use in clinical practice.
Self‐reactive B cells are increased in all major stages of peripheral development in Sjögren's disease
Authors: Lee Adrian YS , Qi Zhankun , Jackson Katherine JL , Reed Joanne H
Published: February 2025

Sjögren's disease (SjD) is a chronic autoimmune disorder characterized by increased circulating self‐reactive B cells. While many of these self‐reactive B cells emerge from the bone marrow, it is not known whether they are excluded from or enriched in specific developmental stages in the periphery. The aim of this study was to determine the immunophenotype of circulating self‐reactive B cells in SjD to inform more precise therapeutic targeting. Five major B cell populations: transitional, mature naïve, switched memory, double negative and plasmablasts were single‐cell sorted and cultured to produce IgG. Self‐reactive IgG was identified by ELISA, flow cytometry of permeabilized HEK293 cells and HEp‐2 indirect immunofluorescence. Immunoglobulin heavy chains were sequenced by Sanger and next‐generation sequencing. Compared with healthy donor controls (HCs), SjD patients had higher frequencies of naïve and CD21low atypical memory B cell subsets, while antigen‐experienced B cells expressed more Ki67 and CD86. B cells recognizing intracellular self‐antigens were identified in all stages of peripheral B cell development for SjD and HCs, but frequencies of autoreactive B cells were up to 10‐fold higher in SjD. Self‐reactive transitional B cells expressed higher surface CD38 and lower surface IgM. An increase in self‐reactive B cells throughout peripheral development in SjD compared with HCs suggests that counterselection of autoantibody‐bearing B cells during central and peripheral tolerance checkpoints are reduced in SjD. Therapeutic strategies focused on depleting B cells based on B cell receptor specificity rather than the developmental stage would be more efficient to target self‐reactive B cells in SjD.
Factors Influencing Contact Force in Robotic Magnetic Navigation Ablation
Authors: Orczykowski Michal , Bak Maciej , Kaczmarek Krzysztof , Urbanek Piotr , Robert Bodalski , Dubowski Krzysztof , Warminski Grzegorz , Derejko Pawel , Ptaszynski Pawel , Sterlinski Maciej , Bilinska Maria , Szumowski Lukasz
Published: February 2025

Introduction

Stability of catheter‐tissue contact in the robotic magnetic navigation (RMN) system is one of the key features that distinguishes this system from manually guided catheters. Numerous studies have shown that contact force (CF) in manually controlled catheters is as crucial for forming an optimal lesion as the duration of application or power. Catheters used in the RMN system lack a quantitative method for intraoperative monitoring of this parameter. Our study aims to partially address this gap in scientific knowledge.

Methods

We conducted a total of 1200 CF measurements using the RMN system (Stereotaxis, St. Louis, MO, USA), a magnetic‐guided 8 Fr RF ablation catheter (THERMOCOOL RMT Catheter, Biosense Webster, Irvine, CA, USA) inserted through a long sheath (SR0, Abbott Cardiovascular, Nathan Lane North, Plymouth, MN, USA), and a precision jewelry scale (IKEME, Guangdong, CN). We analyzed the impact on the obtained CF values of four different magnetic field vectors (transverse, sagittal, caudal, and cranial), two field strengths (0.1T and 0.08T), and three catheter extension configurations from the long sheath (with Position 1 being the least extended and Position 3 the most extended).

Results

The contact force values varied significantly across the different magnetic field vectors, field strengths, and catheter extensions from the vascular sheath.

The greatest differences in achieved values were observed across the different magnetic field vectors in the Position 1, ranging from 3.52 ± 0.1 g (caudal plane) to 15.15 ± 0.05 g (cranial plane) at 0.08 Tesla (T) field strength (p < 0.001), and from 4.10 ± 0.06 g (caudal) to 15.01 ± 0.07 g (cranial) at 0.1 T, p < 0.001. Differences in other vectors reached approximately 20%.

The highest CF values were obtained in Position 1, intermediate values in Position 2, and the lowest in Position 3. An exception was the transverse vector, where, particularly with a magnetic field of 0.1 T, more similar values were observed across Positions 1–3, with respective values of 8.61 ± 0.14 g, 9.36 ± 0.06 g, and 8.31 ± 0.05 g.

A stronger magnetic field (0.1 T compared to 0.08 T) resulted in higher CF values, especially during measurements in the transverse vector. This effect was most pronounced in the most extended catheter from the sheath ‐ Position 3 (with respective values of 4.54 ± 0.09 g vs. 8.31 ± 0.05 g, p < 0.001). In the sagittal, cranial, and caudal vectors, the differences were less noticeable.

Conclusion

Different magnetic field vectors, catheter extensions from the sheath, and magnetic field strengths result in varying contact force values. For effective radiofrequency ablation lesions, these factors should be considered alongside power, duration, and other established parameters.
Spiritual Care Experiences of Nurses Working in Gynecology Clinic: A Qualitative Research
Authors: Başaran Fatma , Şahin Merve , Salık Hava
Published: February 2025

Rationale

Pregnancy and childbirth are among the most important events in a woman's reproductive life. In this process with full of uncertainties, nurses who provide primary care to women play a key role. Spiritual care is an important part of holistic care and an indicator of quality of care.

Aim

This research aims to thoroughly examine and describe the spiritual care experiences of nurses working in obstetrics and gynecology clinics specific to their clinics.

Methods

The study was carried out based on the descriptive phenomenology type of phenomenology design, one of the qualitative research methods. The study group included nurses in gynecology clinics in different provinces and hospitals in Turkey. The criterion sampling method, one of the purposive sampling methods, was used, and 12 nurses comprised the sample size. A semi‐structured interview form was used to collect the data. In evaluating the obtained data, thematic content analysis and MAXQDA 22 software were used. The study was written based on the COREQ checklist.

Results

The data obtained from the interviews were analyzed under six themes: the concept of spiritual care, spiritual care practices, factors complicating spiritual care, factors facilitating spiritual care, emotional effects of spiritual care, and recommendations on the best way to provide spiritual care.

Conclusions

It is vital to train gynecology nurses in spiritual care, reduce their workload, and develop clinical practice guidelines. Increasing the awareness of obstetric nurses about the factors affecting their spiritual care experiences while caring for individuals in clinical practices will contribute to increasing the quality of nursing care.
Optimal Flood Discharge Scheduling to Alleviate Vibration Under Gate Operational Rules
Authors: Yang Zetai , Feng Suzhen , Fu Kaixiang , Wang Jinwen
Published: February 2025

The concomitant vibration of flood discharge, which would cause structure damages to hydraulic infrastructure and thus incurs threats to nearby communities, has rarely been addressed yet cries for an effective solution in discharge scheduling of sluice gates. This work improves on the traditional practice (Model‐I) that mainly aims to restrain start‐up and shutdown actions of spillway gates with a new model (Model‐II) that includes a flexible vibration damping rule, in which the sluice gates are grouped in priority to be sequentially committed, and in the same group, a reference gate is prioritised to enforce a uniform discharge from the active outlets and the gates are paired to ensure a symmetrical opening. The case studies in the Xiangjiaba Dam (XD) demonstrate the excellent adaptability of the model to gate opening patterns concluded with field experiments and site monitoring, and comparing the two models reveals that Model‐II can enforce preferable operational rules to deliver safer discharge scheduling and potentially to reduce risks from the concomitant vibration of hydraulic facilities and the turbulent flow field around the dam during flood discharging, though leading to a much higher frequency of starting up and shutting down of sluice gates than the traditional Model‐I.
Intersectionality
Authors: Echeverria Alejandro
Published: February 2025

In this piece, I explore the “pretty word” of intersectionality to contribute to existing discussions on its usage as an analytical framework and tool among social justice projects. Through my personal queer journey in podcasting, the coming‐out experience, and traversing across various spaces, I highlight the importance of incorporating a relational, embodied, and geographic perspective within intersectionality. I reveal how this perspective can unsettle common assumptions about social identities, specifically a fixed view of racialized‐sexualized identities and the location of oppressions and privileges. Through various situations, movements, and reflections, I uncover an emerging approach to intersectionality that exists in relation to different spatialities and temporalities rather than in isolation. I reveal the limits of common applications of intersectionality in health equity research while also recognizing the pitfalls that some institutions and social actors fall into while promoting diversity, equity, and inclusion, including the reproduction of common ideas of victimhood and superiority. Ultimately, this article advocates for building new worlds by reworking the ways researchers and communities connect and relate with one another and themselves.