bluuebunny/crossref_metadata_2025 huggingface dataset:
Preclinical Assessment of the Proliferation Capacity of Gingival and Periodontal Ligament Stem Cells from Diabetic Patients
Authors: Assem Mostafa , Kamal Samia , Sabry Dina , Soliman Nadia , Aly Riham M.
Published: February 2018

BACKGROUND: Stem cells have recently received great interest as potential therapeutics alternative for a variety of diseases. The oral and maxillofacial region, in particular, encompasses a variety of distinctive mesenchymal (MSC) populations and is characterized by a potent multilineage differentiation capacity.AIM: In this report, we aimed to investigate the effect of diabetes on the proliferation potential of stem cells isolated from controlled diabetic patients (type 2) and healthy individuals.SUBJECTS & METHODS: The proliferation rate of gingival and periodontal derived stem cells isolated from diabetic & healthy individuals were compared using MTT Assay. Expression levels of Survivin in isolated stem cells from all groups were measured by qRt - PCR.RESULTS: There was a significantly positive correlation between proliferation rate and expression of Survivin in all groups which sheds light on the importance of Survivin as a reliable indicator of proliferation. The expression of Survivin further confirmed the proliferation results from MTT Assay where the expression of stem cells from non - diabetic individuals was higher than diabetic patients. Conclusion: Taking together all the results, it could be concluded that PDLSC and GSC are promising candidates for autologous regenerative therapy due to their ease of accessibility in addition to their high proliferative rates.
Brown Tumour in the Mandible and Skull Osteosclerosis Associated with Primary Hyperparathyroidism – A Case Report
Authors: Popovik-Monevska Danica , Bozovik-Dvojakovska Suzana , Popovski Vladimir , Benedetti Alberto , Grchev Aleksandar , Koneski Filip
Published: February 2018

BACKGROUND: The hyperparathyroidism (HPT) is a condition in which the parathyroid hormone (PTH) levels in the blood are increased. HPT is categorised into primary, secondary and tertiary. A rare entity that occurs in the lower jaw in association with HPT is the so-called brown tumour, which an osteolytic lesion is predominantly occurring in the lower jaw. It is usually a manifestation of the late stage of the disease. Osteosclerotic changes in other bones are almost always associated with renal osteodystrophy in secondary HPT and are extremely rare in primary HPT. This article reports a rare case of a brown tumour in the mandible as the first sign of a severe primary HPT, associated with osteosclerotic changes on the skull.CASE REPORT: A brown tumour in the mandible was diagnosed in 60 - year old female patient with no previous history of systemic disease. The x - rays showed radiolucent osteolytic lesion in the frontal area of the mandible affecting the lamina dura of the frontal teeth, and skull osteosclerosis in the form of salt and pepper sign. The blood analyses revealed increased values of PTH, calcitonin and β – cross-laps, indicating a primary HPT. The scintigraphy of the parathyroid glands showed a presence of adenoma in the left lower lobe. The tumour lesion was surgically removed together with the lower frontal teeth, and this was followed by total parathyroidectomy. The follow - up of one year did not reveal any signs of recurrence.CONCLUSION: It is critical to ensure that every osteolytic lesion in the maxillofacial region is examined thoroughly. Moreover, a proper and detailed systemic investigation should be performed. Patients should undergo regular check-ups to prevent late complications of HPT.
Age, growth and mortality of Sciaena umbra (Sciaenidae) in the Gulf of Tunis
Authors: Chater Inès , Romdhani-Dhahri Ahlem , Dufour Jean Louis , Mahé Kélig , Chakroun-Marzouk Nadia
Published: February 2018

The growth and mortality of the brown meagre, Sciaena umbra from the Gulf of Tunis, were investigated using a sample of 276 specimens, ranging from 15.3 to 49.2 cm total length and from 43 to 1565 g total weight. Specimens were collected from artisanal fisheries between October 2008 and September 2011. Otoliths were extracted, thin cross-sections were realized and radii were measured. The log-linear morphometric relationships between total length-total weight and total length-otolith radius were significant (p < 0.05), showed positive allometry (b=3.15) and isometry (b=0.90), respectively. The marginal analysis suggested that only one growth increment was deposited per year. The maximum age of the brown meagre was 22 years for males and 31 years for females. The fit of the von Bertalanffy growth function was significantly different between sexes (p
The Synthesis and Photocatalytic Performance of Samarium Doped Mesoporous Titania
Authors: Shi Jian Wen , Ma Dan Dan , Zou Ya Jun
Published: February 2018

The meso-porous TiO2 and Sm-doped meso-porous TiO2 were synthesized by a sol-gel method. Polyethylene glycol, with different added content, was added as a structure-directing agent. The prepared meso-porous TiO2 was characterized by nitrogen adsorption, X-ray diffraction and ultraviolet-visible diffuse reflectance spectroscopy, and the photocatalytic performance was evaluated by the decomposition of methyl orange. The results revealed that PEG plays a key role in creating porous structure during the heat-treatment. The photocatalytic performance of TiO2 is improved by adding proper content PEG, and Sm-doping can further promote the photocatalytic performance.
An Efficient Optoelectronic System for Remote Salinity Water Sensing
Authors: Villarreal Jiménez Leopoldo René , Rodríguez Rodríguez Adolfo Josué , Enríquez Sías Sarmach Ulianov , Elizondo González Cesar , Barrón González Héctor Gilberto , Erro Betrán María José , Rodríguez Rodríguez Wenceslao Eduardo , Domínguez Cruz René Fernando
Published: February 2018

In this work, we proposed and demonstrated an efficient optoelectronic system capable to detect 1 gram of salt per liter of water (0.1% salinity) in real time employing optical fiber technology as sensing medium and embedded systems of National Instruments Company to get an accurate instrumentation process. In addition, the sensitivity of this salinity sensor can be enhanced by reducing the diameter of the optical fiber sensor structure ( by employing a controlled tapering process. More specifically, the sensitivity of this device has been raised from 141.933 nm/Refractive Index Unit (RIU) for an un-tapered sensor structure to 352.915 nm/RIU for a tapered sensor structure . In fact, considering that the tapered sensor structure provides an approximately linear response with a maximum sensitivity of 0.6624 nm / % salt, the percentage of salt is easily identified by monitoring the peak wavelength response.
Dynamic Behavior of a Cracked Woven Composite Beam under Compression
Authors: Demirci Ismail , Yetmez Mehmet
Published: February 2018

In this study, numerical dynamic analysis of E-glass fiber plain weave composite beams with crack under compression is considered. Before understanding the compression effect on the beam, the dynamic characteristics of the models are compared with the experimental evaluations. Results are given in tabular and graphical form.
Research on Highway Intelligent Monitoring and Warning System Based on Wireless Sensor Network
Authors: Guan Zhi Guang , Miao Qiu Hua , Si Wen Hui , Lu Jing , Liang Jie
Published: February 2018

The intelligent monitoring and warning system in highway fog section can realize timely forecast, early warning and information integration in low visibility condition. It can supply the scientific basis to highway decision-making management and technology to establish highway intelligent transportation system. The self-developed intelligent monitoring and warning system includes vehicle detector, camera, variable information board, ZigBee modules and controller EUC. The system can greatly reduce the traffic accidents caused by fog. Result shows that the system has high precision and reliability.
Using Micro-Simulation VISSIM to Study the Effectiveness of Left-Turn Waiting Area Implementation
Authors: Sun Da Zhi
Published: February 2018

Numerous attempts have been made to improve the existing intersection systems to maximize capacity and reduce the delay costs and queues. This paper introduces a simulation method to study the effectiveness of a new technique introduced recently in China – the left-turn waiting area. This has an extended left lane that allows the vehicles to wait before the signal turns green. It is reported that this system can significantly improve intersection performance. This paper introduces the different types of left-turn waiting areas which have been widely implemented in China. The method of using micro-simulation VISSIM to study the effectiveness of left-turn waiting area is proposed in this paper, along with some preliminary results of a case study.
Removal of Cu2+ from Aqueous Water by Adsorption onto the Efficient and Recyclable Durian Shell-Derived Activated Carbon
Authors: Bach Long Giang , Vo Dai Viet Nguyen , Trinh Nguyen Duy , Ho Van Thi Thanh , Tran Van Thuan
Published: February 2018

We investigated the use of durian shell-derived activated carbon (DSAC) for the removal of Cu2+. To determine the optimal condition for Cu2+ removal, the response surface methodology (RSM) was used to establish a second-order polynomial model with variables such as Cu2+ concentration (Ci), adsorbent dosage (dDSAC) and pH. With R2 = 0.9847 and P-value < 0.0001, the model was proved to be statistically significant. The RSM based confirmation test revealed that the removal of Cu2+ was maximum (99.6%) at optimal conditions: Ci = 61.6 mg/L, dDSAC = 5.0 g/L and pH = 5.2. Based on calculated R2, data fitness for adsorption isotherms were positioned as follows: Langmuir > Tempkin > Freundlich. In other words, monolayer adsorption was the most favorable behavior with maximum capacity of 76.92 mg/g from Langmuir model. Interestingly, DSAC was reused at least five times without a considerable decrease of Cu2+ removal efficiency. Therefore, durian shell can be used as a highly effective, reusable and promising raw material to fabricate the activated carbon.
Preparation and Characterization of Advanced PtRu/Ti0.7Mo0.7O2 Catalysts for Direct Methanol Fuel Cells
Authors: Ho Van Thi Thanh , Bach Long Giang , Vo Dai Viet Nguyen
Published: February 2018

We report the new strategy by investigating the novel Ti0.7Mo0.3O2material can just as easily be used as a conductive support for PtRu for DMFCs to prevent not only the carbon corrosion but also improved activity of catalyst due to some functional advantages of novel Ti0.7Mo0.3O2support. The Ti0.7Mo0.3O2nanoparticle have good crystallinity with well-defined fringes corresponding to the 3.45 Å spacing value of the {101} plane of anatase TiO2, which were good according to the XRD pattern. The BET surface area measurements showed that the Ti0.7Mo0.3O2possessed 125 m2g-1Fig. 3 shows the TEM measurement of Ti0.7Mo0.3O2nanoparticle and Pt/Ti0.7Mo0.3O2, it can be observed that spherical PtRu alloy particles with an average particle size of 2-4 nm were uniformly anchored on the surface of Ti0.7Mo0.3O2support. More importantly, we found that there has a strong metal support interaction (SMSI) between the PtRu noble metal and the Ti0.7Mo0.3O2support material - resulting in facile electron donation from the Ti0.7Mo0.3O2support to PtRu metal with an ultimate drastic decrease in the d-band vacancy of Pt. Thus, the unique structural features of the Ti0.7Mo0.3O2support and the PtRu/Ti0.7Mo0.3O2catalyst appear to provide a suitable combination favoring that promise for the high performance of methanol oxidation, CO-tolerance in DMFCs.
Synthesis the New Nanostructure Ti0.7W0.3O2 via Low Temperature Solvothermal Process
Authors: Huynh Tai Thien , Pham Hau Quoc , Nguyen At Van , Bach Long Giang , Nguyen Son Truong , Ho Van Thi Thanh
Published: February 2018

The materials currently used in proton-exchange membrane fuel cells (PEMFCs) require complex control of operating conditions to make them sufficiently durable to permit commercial deployment. One of the major materials challenges to allow simplification of fuel cell operating strategies is the discovery of catalyst supports that are much more stable to oxidative decomposition than currently used carbon blacks. Here, we report the synthesis and characterization of advanced nanostructure Ti0.7W0.3O2prepared via a low-temperature solvothermal process without using any surfactants or stabilizers. A promising doped metal oxide is a candidate for such a durable catalyst support. The synthesized nanoparticles were characterized by XRD, TEM measurements. Results show that Ti0.7W0.3O2exists in a single-phase solid solution with anatase phase of TiO2. Interestingly, the average particles size approximately 5 nm that could be promised to have a large specific surface area, which is an extremely important factor for promising catalyst support. Moreover, Ti0.7W0.3O2synthesized at 200 °C for 6 hours obtains the smaller particles size without particles agglomeration compared to previous researches. These results open a new approach for synthesis nanostructure Ti0.7W0.3O2by a solvothermal process for further application as catalyst support in PEMFCs.
‘Whatever became of that earlier time of grace?’ Luther, Bonhoeffer and the quincentennial
Authors: Van der Westhuizen Henco
Published: February 2018

The quincentenary of the Protestant Reformations creates a challenge. With reference to Protestant churches in South Africa, the ambiguity inherent in this challenge is considered in the first part of the essay. In the second part, Martin Luther’s famous discovery is investigated in light of his earlier theology leading up to 31 October 1517. It is argued that Luther’s earlier theology is characterised by a hermeneutic rediscovery. In the third part, Dietrich Bonhoeffer’s theology is brought into conversation with Luther. It is asked how Bonhoeffer received Luther’s theology – more specifically, how he re-appropriated the hermeneutic inherent in Luther’s earlier theology. In the final part, it is asked what the theological hermeneutic inherent in Luther’s earlier theology – re-appropriated by Bonhoeffer – can mean for South African churches commemorating the Protestant Reformations.
The portrayal of Africa and Africans in the book of Jeremiah
Authors: Adamo David T.
Published: February 2018

Since the 1980s, many Jeremianic scholars have spent much time on the study of the various contentious issues in order to resolve them. However, there has been no unanimous agreement yet. One of these contentious issues is the relationship of the prophet Jeremiah to ancient Africa and Africans which is the main focus of this article. The author of the book Jeremiah made references to Ancient Africa and Africans about 53 times in the Septuagint, and 67 times in the Masoretic Text. This indicates that the prophet Jeremiah is very familiar with ancient Africa and Africans. Using a historical–biographical and theological method of reading Jeremiah, this article examines the portrayal of ancient Africa and Africans in the book of Jeremiah. It is also part of an investigation of the African presence in the Old Testament which, to Africans, is an important moral and self–lifting scholarly exercise. It is also gratifying information in itself to know that Africa and Africans have participated in the drama of redemption which has not been recognised as such by either Eurocentric scholars or by the majority of Africentric scholars themselves. While in the Pentateuch references to Africa and Africans appear more than 577 times, in the Major Prophets there are about 180 references. What this means is that not only the author of the book of Jeremiah, but biblical authors in general are very familiar with ancient Africa and Africans, and deliberately took time to identify them. The continued recognition by scholars and non–scholars of Africa and African presence in the Bible has great implications for Christianity in Africa.
Monitoring and evaluation: The missing link in South African municipalities
Authors: Mello David M.
Published: February 2018

The Auditor-General of South Africa reports for the financial years 2012–2013, 2013–2014 and 2014–2015 paint a gloomy picture of local government performance in some provinces. Many municipalities in South Africa are not performing as expected because of a host of problems that include weaknesses in monitoring and evaluation systems. The study preceding this article was qualitative in nature and focused on the Auditor-General’s reports for the 2012– 2013, 2013–2014 and 2014–2015 financial years. Main findings of the study are that municipalities that get clean audits have strong oversight systems and leadership. A further inference is that qualifications of councillors, training, time and remuneration are contributing factors to poor oversight by councillors and political structures. The main recommendations were directed at improving civic education in the nomination and election of councillors, pairing underperforming municipalities with best performing municipalities, improving continuing education for councillors and improving the monitoring of interventions and the transitions after interventions
On weak and strong solution operators for evolution equations coming from quadratic operators
Authors: Aleman Alexandru , Viola Joe
Published: February 2018

We identify, through a change of variables, solution operators for evolution equations with generators given by certain simple first-order differential operators acting on Fock spaces. This analysis applies, through unitary equivalence, to a broad class of supersymmetric quadratic multiplication-differentiation operators acting on

L^2 (\mathbb R^n)

which includes the elliptic and weakly elliptic quadratic operators. We demonstrate a variety of sharp results on boundedness, decay, and return to equilibrium for these solution operators, connecting the short-time behaviorwith the range of the symbol and the long-time behavior with the eigenvalues of their generators. This is particularly striking when it allows for the definition of solution operators which are compact and regularizing for large times for certain operators whose spectrum is the entire complex plane.
Differential equations for discrete Jacobi–Sobolev orthogonal polynomials
Authors: Durán Antonio J. , de la Iglesia Manuel D.
Published: February 2018

The aim of this paper is to study differential properties of orthogonal polynomials with respect to a discrete Jacobi–Sobolev bilinear form with mass point at –
An inequality for the Steklov spectral zeta function of a planar domain
Authors: Jollivet Alexandre , Sharafutdinov Vladimir
Published: February 2018

We consider the zeta function

\zeta_\Omega

for the Dirichlet-to-Neumann operator of a simply connected planar domain

\Omega

bounded by a smooth closed curve. We prove that, for a fixed real

s

satisfying

|s|>1

and fixed length

L(\partial \Omega)

of the boundary curve, the zeta function

\zeta_\Omega(s)

reaches its unique minimum when

\Omega

is a disk.This result is obtained by studying the difference

\zeta_\Omega(s)-2\big({L(\partial \Omega)\over 2\pi}\big)^s\zeta_R(s)

, where

\zeta_R

stands for the classical Riemann zeta function. The difference turns out to be non-negative for real

s

satisfying

|s|>1

. We prove some growth properties of the difference as

s\rightarrow\pm\infty

. Two analogs of these results are also provided.
Premier isolement de Haemophilus somnus chez un bovin en France
Authors: Martel Jean-Louis , David C. , Bonnier M. , Michel R. , Gérard R. , Frappier Evelyne
Published: February 2018

Une souche de Haemophilus somnus a été isolée en France en 1985 à partir de lésions de pleuro-bronchopneumonie chez une génisse. Cette bactérie a été comparée à deux souches de Haemophilus somnus provenant de Suisse.

Cliniquement, l'animal avait présenté des troubles diarrhéiques évoluant pendant plusieurs semaines et pouvant être rapportés à une infection par le virus de la maladie des muqueuses compliquée, 2 mois plus tard, d'une atteinte de l'appareil respiratoire par Haemophilus somnus. Les difficultés d’isolement et d'identification de cette bactérie sont évoquées.
Anabolisants et bovins de boucherie : I. Bœufs à l'herbe
Authors: Willemart Jean-Pierre , Bouffault Jean-Claude
Published: February 2018

Un essai a été fait sur 80 bœufs pesant environ 680 kg au moment du traitement (16 avec E2 + P, 16 avec Z + TBA, 16 avec E2 + TBA, 32 témoins).

Ces bœufs étaient nourris sur pâture permanente enrichie par épandage d'azote.

Les résultats sont intéressants (augmentation des gains de poids vif par rapport aux témoins de 87,7 % pour E2 + P, 83,7 % pour Z + TBA, 104,6 % pour E2 + TBA).

Cependant, les pâturages ne peuvent fournir assez d'aliment pour atteindre l'optimum des résultats.

Il faut donc envisager dans le cas des bœufs en pâture, la distribution d’un aliment complémentaire de l'herbe.
La maladie d'Aujeszky en France
Authors: Métianu Tibérius , Guillemère Simone
Published: February 2018

La première période, 1912-1964, fait apparaître des cas sporadiques chez les bovins, chiens, chats suspectés d’après les signes cliniques et rarement transmis par inoculation expérimentale chez le lapin.

La deuxième période, de 1965 à nos jours, a permis de découvrir la maladie d'Aujeszky pour la première fois en France, chez le porc. Maladie confirmée par l'isolement du virus, recherches d'anticorps neutralisants et reproduction de la maladie. Pendant la même période et dans les mêmes conditions, la maladie était décelée chez le chien et chez le chat. .

En 1965, avec cinq foyers dans un seul département, la maladie d'Aujeszky connaît une extension foudroyante pour atteindre, en 1983, 344 foyers répartis dans 53 départements et d'être, aujourd’hui, disséminés sur l'ensemble du territoire.

Le porc, réservoir du virus diffuse la maladie dans l'effectif porcin contaminé, pu non contaminé et chez toutes les espèces sensibles.
Emergence de bactéries dites saprophytes des genres Aeromonas, Enterobacter (Erwinia) et Serratia dans les avortements bactériens chez la jument
Authors: Vaissaire Josée , Plateau Éric , Laugier Claire , Laroche Micheline , Mirial Ginette
Published: February 2018

Les auteurs décrivent l'émergence de bactéries saprophytes : Aeromonas hydrophila, Enterobacter agglomerans (Erwinia herbicolà ) et du genre Serratia dans les avortements bactériens chez la jument. 49 souches / 302 souches isolées de plus de 200 cas.

Cette étude a été faite sur 4 ans (1981-1985) et montre que ces germes provoquent 16 % des avortements bactériens de l'espèce équine.

Les germes du genre Serratia (Serratia marcescens, Serratia liquefaciens, Serratia rubidea) sont en général multirésistants aux antibiotiques.

Les conditions d'apparition de ces avortements ne sont pas encore bien définies.
Isolement d’Adénovirus de type 1 (FAV-1) chez des dindes atteintes de rhinotrachéite
Authors: Meulemans G. , Schricke E.
Published: February 2018

Des examens virologiques : immunofluorescence directe sur coupes d'organes, essais d’isolement viral sur oeufs embryonnés et cellules hépatiques d’embryon de poulet ainsi que des colorations spécifiques destinées à la recherche de Chlamydia psittaci ont été effectués dans 12 élevages de dindes atteintes de rhinotrachéite.

Un adénovirus a été isolé des organes respiratoires, du plasma ou des matières fécales dans 7 des 12 exploitations. A l'exception d’un paramyxovirus de type 1 isolé dans une exploitation, aucun autre virus ou chlamydies n'a pu être mis en évidence dans les troupeaux testés.

Le typage sérologique des adénovirus isolés a montré que 6 d'entre eux appartiennent au sérotype FAV-1 (CELO). Une séroconversion contre les virus FAV-1 a été observée dans des troupeaux de dindes ayant présenté des signes cliniques de rhinotrachéite.

Le rôle étiologique éventuel des adénovirus dans la rhinotrachéite de la dinde est discuté.
La méthode Norecoin en restauration collective sociale. Premiers résultats
Authors: Catsaras Marc , Danjou Jean-Paul , Seynave René Lucien
Published: February 2018

La méthode d'analyse Norecoin (normalisée, répétitive, codée et intégrée) a été appliquée à 62 restaurants de restauration collective sociale (restaurants scolaires) au cours de l’année 1985. L'examen des notes obtenues a permis de confirmer la valeur de la méthode et de montrer que leur structure est particulière dans ce cas. Il peut être recommandé d'estimer satisfaisant d’obtenir < 5 % de plats cuisinés non conformes et < 10 % de plats autres (entrées ou desserts) non conformes ou non satisfaisants. Cela correspond, avec la méthode Norecoin, à des notes de groupe > 2,5.
Chimiothérapie de la rage
Authors: Bussereau-Plunian Françoise , Picard Monique , Malick Caroline , Blancou Jean , Sureau P.
Published: February 2018

Forty five drugs were administrated to rabies infected mice in such conditions that they could be in contact with the infected cells i.e. intramuscularly at the site of virus inoculation and intracerebrally when the virus reached the central nervous system, brain more precisely. Hétéropolyanions, (more precisely HPA 39) prevented the development of clinical infection when injected intramuscularly early by I.M. All the treated surviving mice, developed rabies neutralizing antibodies. No proof was found of viral multiplication in their brains. This hétéropolyanion was administrated to rabies infected foxes. The efficacy of this compound was evident considering the prolongation of mean survival time and number of survivors. These data on HPA treatment suggest that chemotherapy might be worthwhile when vaccine treatment is impossible.
Avec présentation d'un modèle ancien déclaré d'Afghanistan : le mors à gourmette anneau
Authors: Rousseau Michel
Published: February 2018

Ce mors provient d’une vente : pour l’Afghanistan, où il aurait été forgé il y a environ 150 ans, et serait, depuis longtemps, inusité.

Il est opposé aux mors traditionnels (franco-anglais) à gourmette (chaînette) : de filet brisé ou de bride.

Il est alors décrit avec mensurations ; puis comparé à ceux du même type : à gourmette-anneau. Est discutée leur dureté ; puis celle que pouvait avoir ce mors, avec essai en bouche satisfaisant.

Est enfin montré l’intérêt multidisciplinaire des mors. La gourmette-anneau est typique des pays qui ont reçu l’Islam, ou son influence : par l’Espagne et le Portugal jusqu’aux Amériques.
Infection par le Rotavirus chez le veau : effet protecteur de la smectite
Authors: Navetat Hervé , Droy-Lefaix Marie-Thérèse , Espinasse Jacques , Parodi André-Laurent
Published: February 2018

Chez les veaux nouveau-nés, l’infection par le rotavirus est à l’origine de gastroentérites. Les signes diarrhéiques apparaissent 48 heures après l’inoculation.

L’observation clinique montre que certains veaux sont anorexiques, d’autres deviennent nonchalants et prennent un poil piqué ; des signes de déshydratation apparaissent à 4 jours.

L’observation ultrastructurale en microscopie électronique à balayage confirme l’effet pathogène du rotavirus.

Sur certaines villosités iléales, les entérocytes sont gonflés avec disparition du glycocalyx et altération du tapis des microvillosités. Sur d’autres villosités, des grandes plages érodées sont visibles avec desquamation de l’épithélium et nécrose du chorion.

Si les veaux nouveau-nés reçoivent après l’inoculum de rotavirus, une argile, la smectite, à la dose de 500 mg/kg pendant 4 jours, les signes diarrhéiques sont considérablement réduits ; aucun signe clinique concernant le comportement et la déshydratation n’est observé. D’un point de vue ultra-structural, les villosités iléales gardent un aspect normal. En conclusion, la smectite par ses propriétés d’adsorption du rotavirus et ses effets sur le mucus adhérent protège ainsi la muqueuse iléale des effets pathogènes du rotavirus.
Une exposition : «Sous le signe du taureau»
Authors: Rousseau Michel
Published: February 2018

“Under the bull’s sion”

This parisian exhibition combines, about bull and “corrida”, works of about sixty artists, among whom Goya, Manet and Picasso, photographs from Michel Dieuzaide, a documentation (cartographies...) since aurignacian art (too old, here), then from Crete. As extend of magic and cults, “corrida”, incurs disapproving. This exhibition and its little guide-book are briefly located in die symbolism of bull.
Sur certaines de nos observations concernant l'épizootiologie, la pathogénie et la prophylaxie des entérites provoquées par Clostridium perfringens des types A et C
Authors: Katitch Relja V.
Published: February 2018

Les entérites provoquées par les germes Cl. perfringens (A et C) sont des maladies caractérisées par une toxémie générale et une bactériémie qui se produisent après une multiplication intensive dans l’intestin des germes Cl. perfringens. Dans la plupart des cas, il s’agit de maladies à évolution foudroyante où la mort survient 12 à 48 heures après l’apparition des premiers symptômes. Elles sont dues, particulièrement en Yougoslavie, à l’ingestion des aliments contaminés (surtout des farines de viande). Des techniques modernes de conduite de l’élevage ont augmenté la fréquence des maladies. Etant donné la relation directe entre l’apparition de ces infections et les techniques modernes d’élevage, il convient de porter une grande attention à l’hygiène des aliments susceptibles d’être contaminés par Cl. perfringens. Les faits mentionnés demandent de fixer des normes pour le contrôle bactériologique des produits alimentaires préparés industriellement. Parallèlement, il faut utiliser l’immunoprophylaxie avec un vaccin mixte préparé, d’après la situation épizootiologique du terrain, avec des souches immunogènes en appliquant la vaccination en temps utile.
Particularités écologiques et physiologiques des rongeurs désertiques
Authors: Petter Francis
Published: February 2018

Les rongeurs qui vivent dans le désert sont bien adaptés à la pauvreté de ce milieu en ressources alimentaires. Ils se protègent bien des conditions extrêmes du climat en vivant dans des terriers. Us sont obligés de parcourir de grandes distances pour récolter des graines ; leur densité de peuplement est faible. En compensation ils communiquent entre eux par des signaux spéciaux, appelés «podophones >, que leur oreille moyenne très spécialisée peut recevoir de loin.

La plupart des rongeurs désertiques sont nocturnes et granivores ; ils ne boivent pas mais utilisent de l’eau métabolique ; leur urine est très concentrée et ils perdent le moins possible d’eau par les fèces et par la respiration. Par contre, une espèce, Psammomys obesus, est diurne et strictement herbivore ; chaque individu mange chaque jour presque son poids de plantes riches en sel de la famille des Chénopodiacées.
Importance du microbisme dans les spermes d’étalons
Authors: Vaissaire Josée , Plateau Éric , Laugier Claire
Published: February 2018

Les auteurs décrivent l’importance du microbisme dans les spermes d’étalons. L’étude a été faite sur 235 spermes de différentes races de chevaux. La contamination par les Klebsiella, les Streptococcus (equisimilis et zooepidemicus), les Staphylococcus aureus et les Escherichia coli peut être importante.

D’autres germes saprophytes potentiellement pathogènes peuvent être trouvés : Aeromonas, Enterobacter, Serratia, Acinetobacter, etc.

63 % des spermes sont contaminés : soit par 1 germe (45 %), soit par 2 germes (16,3 %), soit par 3 germes (1,2 %).

Le contrôle bactériologique des reproducteurs avant la saillie devrait être systématique.
Histoire de la lutte contre la petite douve (1936-1986)
Authors: Guilhon Jean
Published: February 2018

La petite douve (Dicrocoelium lanceolatum) longtemps résistante à de nombreux anthelminthiques a, enfin, pu être détruite, en 1962, par 2-(4'-thia-zolyl) benzimidazole à hautes doses (300 à 500 mg/kg). Depuis de nombreux corps, plus spécifiques et à doses plus faibles, aboutissent aux mêmes résultats.
La maladie de Djembrana
Authors: Lobry M.
Published: February 2018

La maladie de Djembrana est une infection transmissible du bœuf de Bali, probablement d’origine virale.

Les lésions macroscopiques consistent en une lymphadénopathie plus ou moins généralisée, une splénomégalie, des hémorragies de l'œdème, des ulcérations des muqueuses et parfois des thromboses.

Les examens hématologiques mettent en évidence de l'anémie et de la leucopénie ainsi que la présence de lymphocytes anormaux dans le sang.

Les lésions microscopiques outre l’œdème, des hémorragies et les thromboses sont caractérisées par une prolifération et une infiltration périvasculaire de ces lymphocytes anormaux dans les ganglions lymphatiques, la rate, le thymus, la moelle osseuse, et de nombreux organes.

Plusieurs maladies infectieuses bovines ont été prises en considération en vue d’établir un diagnostic différentiel.

Il semble que l’on ait affaire à une maladie virale jusqu’à présent non identifiée.
L'allergie : II. Diagnostic et traitement
Authors: Belle G.
Published: February 2018

L’allergie — syndrome multifactoriel complexe — traduit une réaction immunologique comportant tous les degrés, depuis l’éruption bénigne, jusqu’au choc anaphylactique, parfois mortel.

Il existe, en fait, des allergies, en raison de la variété des allergènes et de leur mode de pénétration dans l’organisme (voie digestive, voie respiratoire, voie cutanée).

Le terrain intervient dans les réactions allergiques, ce qui rend encore plus difficile le diagnostic des allergies qui peut être précisé par des tests cutanés, l’épidermo-réaction et les tests de provocation ; la spirométrie et la pléthysmographie permettent de mesurer la sensibilité des allergies respiratoires et d’affirmer ainsi le diagnostic.

Le traitement comporte trois volets : éviction de l'allergène (éventuelle¬ ment) ; la modification du terrain allergique par la désensibilisation ; la médication antiallerginique (antihistaminiques, anti-inflammatoires, médicaments divers dont le cromoglycate disodique [action essentiellement préventive]).

Des travaux sont actuellement en cours à l’Institut Pasteur ainsi que dans des laboratoires de haut niveau pour tenter de découvrir des médicaments antiallergiques, à la fois très actifs et peu toxiques ; un espoir : les antileuco-triènes.
Problèmes liés à l'usage des produits d'intervention et des améliorateurs de performance en élevage intensif
Authors: Raynaud J.-P. , Ruckebusch Yves
Published: February 2018

L’optimisation des performances en élevage intensif implique actuellement l’usage de facteurs de production issus de la chimie et de la pharmacie, parmi lesquels des médicaments pour la thérapeutique, des désinfectants pour l’hygiène, des additifs améliorateurs de performance, etc.

Trois exemples : 1) utilisation de substances chimiques en extemporanée (Chloramphénicol, nitrovine...), 2) effets pervers de suppression des additifs en Suède, 3) prohibition des anabolisants en Europe, soulignent le décalage existant entre les souhaits du législateur et les pratiques en élevage.
L’intervention thérapeutique en productions animales : prochaines améliorations attendues
Authors: Espinasse Jacques , Dewaele A. , Vindevogel H.
Published: February 2018

Pour ses interventions d’urgence comme pour celles mises en place dans le contrôle de la pathologie, le vétérinaire des productions animales disposera dans un proche avenir de moyens de plus en plus performants. Ces progrès concerneront le diagnostic (amélioration de sa précocité, de sa spécificité, de sa sensibilité et de sa rapidité), le traitement (nouvelles molécules, nouveaux procédés, meilleure approche des délais d’attente) et la prévention. Cette dernière devrait bénéficier de l’identification et de la correction de nouveaux facteurs de risques, de nouveaux vaccins et procédés de vaccination et des possibilités offertes par les animaux transgéniques.
Anesthetic Management of a 9-day-old Neonate with Intestinal Evisceration due to Dog Bite
Authors: Jois Sowmya M , Venkatesh Murthy Kallur Thimmarayappa , Ankitha Sunand , Sahajananda Hiremathada
Published: February 2018

Intestinal evisceration following dog bite is rare in neonates. We report a successful anesthetic management of a 9-day-old neonate who was brought to our emergency room with history of stray dog bite 1 hour before presenting. Baby was posted for emergency exploratory laparotomy and procedure.

How to cite this article

Jois SM, Murthy KTV, Ankitha S, Sahajananda H. Anesthetic Management of a 9-day-old Neonate with Intestinal Evisceration due to Dog Bite. J Med Sci 2017;3(4):111-112.
Sudden Death in Sickle Cell Disease: An Autopsy Diagnosis
Authors: Sheshanna Nanditha , Sethi Gurpreet , Prakash Sumitha M
Published: February 2018

Sickle cell disease is a common hereditary hemoglobinopathy with high prevalence in the central and northeastern regions of India. A 24-year-old male patient with 3 days’ history of fever was brought dead to the hospital. Morphology showed clogging of blood vessels with sickled red blood cells (RBCs) in all the organs, and an autopsy diagnosis of sickle cell disease was made. As the cause may not be obvious in many cases, most patients remain undiagnosed. It is important to note the circumstances of death, gross finding, and histopathology, with hemoglobin electrophoresis if available, during autopsy to arrive at the diagnosis. This case is presented here to highlight this fact and draw attention to its pathology.

How to cite this article

Sheshanna N, Sethi G, Raj JA, Prakash SM, Surhonne SP. Sudden Death in Sickle Cell Disease: An Autopsy Diagnosis. J Med Sci 2017;3(4):113-115.
Management of Endodontic Failure
Authors: Nazar Faisal , Raj Aparna , Radhakrishnan Nair K , Alexander Rinsu N , Kumar Meenu M
Published: February 2018

There are several reasons for a root canal therapy to be unsuccessful. One of the causes for endodontic failure is instrument separation. As a consequence of fracture, access to the apical portion of the root canal is obstructed, leading to improper disinfection. The retrieval of separated instrument followed by obturation to the working length is the treatment option. Many factors can make retrieval difficult. In such cases, management can be done even by bypassing the separated instrument. Another factor for endodontic failure is underobturation. It may be due to block or ledge in the apical third of the canal. Proper instrumentation with frequent confirmation of apical patency during instrumentation can prevent formation of ledge. The inability to treat all the canals is the other cause leading to endodontic failure. Bacteria residing in these canals lead to the persistence of symptoms. Proper evaluation of the radiograph with proper deroofing can prevent chances for missed canals. Combination of all these factors can make retreatment difficult. This case report discusses two endodontic failure cases. In the first case, a premolar tooth with separated instrument and incomplete obturation was treated by retrieval of separated instrument and the obturation of both canals to working length was done. The second one was a molar tooth which had a missed canal, a separated instrument, and an incomplete obturation. Missed canal was negotiated and the fractured instrument was bypassed and root canal was obturated.

How to cite this article

Kumar MM, Nair KR, Geetha P, Nazar F, Alexander RN, Raj A. Management of Endodontic Failure. Cons Dent Endod J 2017;2(2):60-64.
Evaluating motives: Two simple tests to identify and avoid entanglement in legally dubious urine drug testing schemes
Authors: Barnes, Esq. Michael C. , Worthy, Esq Stacey L.
Published: February 2018

Objective: This article educates healthcare practitioners on the legal framework prohibiting abusive practices in urine drug testing (UDT) in medical settings, discusses several profit-driven UDT schemes that have resulted in enforcement actions, and provides recommendations for best practices in UDT to comply with state and federal fraud and anti-kickback statutes.Methods: The authors carefully reviewed and analyzed statutes, regulations, adivsory opinions, case law, court documents, articles from legal journals, and news articles.Results: Certain facts-driven UDT arrangements tend to violate federal and state healthcare laws and regulations, including Stark law, the anti-kickback statute, the criminal health care fraud statute, and the False Claims Act.Conclusions: Healthcare practitioners who use UDT can help ensure that they are in compliance with applicable federal and state laws by evaluating whether their actions are motivated by providing proper care to their patients rather than by profits. They must avoid schemes that violate the spirit of the law while appearing to comply with the letter of the law. Such a simple self-evaluation of motive can reduce a practitioner’s likelihood of civil fines and criminal liability.
Morphine prescription to terminally ill patients with lung cancer and dyspnea: French physicians’ attitudes
Authors: Bendiane, MSC Marc K. , Peretti-Watel, PhD Patrick , Pegliasco, MD Herve , Favre, PhD Roger , Galinier, MD Anne , Lapiana, MD Jean-Marc , Obadia, MD Yolande
Published: February 2018

This study aimed to investigate factors associated with analgesic use of morphine in end-of-life care. French general practitioners (GPs) and oncologists (N = 719) were asked whether they would prescribe morphine asfirst-line therapy to patients with terminal lung cancer suffering from dyspnea associated with cough and great anxiety. Overall, 54 percent of oncologists and 40percent of GPs stated that they would prescribe morphine in the presented case. This prescriptive attitude correlated with physicians’ age, professional back-ground, communication skills, and attitude toward terminally ill patients. The findings of this study indicate that improving analgesic use of opioids in end-of-life care is not only a matter of enhancing technical skills acquired through training or experience but also a matter of improving communication and empathy between physicians and patients.
Morphine analgesia in cancer pain: Role of the glucuronides
Authors: Penson, MRCP, MD Richard T. , Joel, PhD Simon P. , Gloyne, BSc Anna , Clark, BSc Simon , Slevin, FRCP, MD Maurice L.
Published: February 2018

Preclinical data and limited studies in humans have suggested that morphine-6-glucuronide (M6G) has analgesic activity and morphine-3-glucuronide (M3G), contributes adversely to the therapeutic effect of morphine. This open point-prevalence study in 103 patients on oral morphine for cancer-related pain investigated the correlations between morphine doses, metabolites, and the degree of pain relief or toxicity. Morphine, M6G, and M3G were assayed by high-performance liquid chromatography on a single blood sample taken between two and four hours after dose. Pain, analgesia, and toxicity were recorded on numerical and visual analog scales. Patients received a median dose of 60 (range, 10 to 620) mg per day morphine, for a median of 4.1 weeks (range, 0.2 to 46.0 weeks). M3G:M6G ratios fell within a narrow range, with a median value of 4.39 (interquartile range, 3.78 to 6.96; range, 2.18 to 14.95). There were no significant correlations between M3G:M6G and morphine dose, or any measure of analgesia. The correlation between plasma concentration and pain score (i.e., better analgesia) was stronger for M6G (r = 0.308, p < 0.01) than morphine (r = 0.197, p = 0.05). These data suggest that M6G contributes significantly to the analgesic potency of oral morphine. No evidence was found for differences in M3G:M6G ratios contributing to analgesia or toxicity.
The metamorphosis of hydromorphone
Authors: Reisfield, MD Gary M. , Wilson, MD George R.
Published: February 2018

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Comparison of transdermal fentanyl with codeine/paracetamol, in combination with radiotherapy, for the management of metastatic bone pain
Authors: Mystakidou, MD, PhD Kyriaki , Katsouda, MD, PhD Emmanuela , Kouloulias, MD, PhD Vassilios , Kouvaris, MD, PhD John , Tsiatas, MD Marinos , Vlahos, MD, PhD Lambros
Published: February 2018

Radiotherapy (R/T) is frequently used for palliative treatment of painful bone metastases; however, complete alleviation of pain is not always achieved. This study was designed to evaluate pain management outcomes and quality of life (QoL) measures in cancer patients with metastatic bone pain receiving a combination of R/T and either transdermal therapeutic fentanyl (TTS-F) patches or codeine/paracetamol.A total of 460 palliative care patients with bone metastases who received R/T were enrolled in this prospective, open-label study. The patients were randomized to initially receive a total dose of 120 mg codeine/paracetamol per day or TTS-F patches releasing 25 μg fentanyl per hour. Pain measures were assessed on the basis of selected questions from the Greek-Brief Pain Inventory. Overall treatment satisfaction (scale, 1 to 4), QoL, and European Collaborative Oncology Group status were also recorded.Among the 460 patients, 422 were eligible for evaluation. Pain measures in the TTS-F group demonstrated statistically significant improvements during the study that were superior to those in the codeine/paracetamol group (p < 0.05). Likewise, there was a significantly greater increase (p < 0.05) in the mean satisfaction score for patients in TTS-F group at every visit between baseline and month two. The vast majority (95.8 percent) of patients in the codeine/paracetamol group increased their medication dosage until the end of the study, whereas in the TTS-F group the respective percentage was only 6.1. Both treatments were generally well tolerated, with constipation as the most common side effect followed by sleep disturbances and nausea. The overall frequencies of side effects were higher in the codeine/paracetamol group.The results therefore indicate that TTS-F offers more effective pain relief than codeine/paracetamol, in combination with R/T, in patients with metastatic bone pain, obtaining complete treatment satisfaction matched by improvements in their QoL.
Methadone-related deaths
Authors: Webster, MD Lynn R.
Published: February 2018

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Adverse effects and cognitive function among primary care patients taking opioids for chronic nonmalignant pain
Authors: Brown, MD Randall T. , Zuelsdorff, BS Megan , Fleming, MD, MPH Michael
Published: February 2018

Chronic opioid therapy is commonly prescribed for chronic nonmalignant pain. Few published data describe the adverse effects experienced by patients with chronic nonmalignant pain being treated by primary care physicians. A prevalence study was conducted on a sample of 1,009 patients (889 receiving chronic opioids) being treated by 235 primary care physicians. Standardized questionnaires and medical record reviews were used to assess rates of addiction, pain diagnosis and severity, opioid adverse effects, and mental health. The mean daily dose of opioids was 92 mg using a morphine-equivalent conversion. Side effects included constipation (40 percent), sleeping problems (25 percent), loss of appetite (23 percent), and sexual dysfunction (18 percent), with patients on daily opioids experiencing more side effects than subjects on intermittent medication. The Medical Outcomes Study Mental Health Inventory (MOS-MHI) cognitive functioning scale indicated poorer cognitive function in the overall sample of chronic pain patients as compared to a general clinical sample (Δ x 95 percent CI = 9.28, 13.76). However, there were limited differences in MOS scores between chronic pain subjects on daily opioids vs. intermittent opioids vs. no prescription opioids. A regression model suggests that psychological measures and pain severity are more predictive of decrements in cognitive function than specific opioid preparations or daily opioid dose. Physicians should closely monitor patients for adverse effects and adequacy of pain control when using chronic opioid therapy for chronic pain treatment. Psychological health, an important predictor of cognitive dysfunction, is a particularly important measure to actively monitor and manage.
Morphine toxicity in renal failure
Authors: Gonçalves, MD Ferraz
Published: February 2018

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