bluuebunny/crossref_metadata_2025 huggingface dataset:
Pyrazole based Furanone Hybrids as Novel Antimalarial: A Combined
Experimental, Pharmacological and Computational Study
Authors: Choudhary Deepika , Rani Isha , Monga Jyoti , Goyal Rajat , Husain Asif , Garg Prabha , Khokra Sukhbir Lal
Published: March 2022

Background:

Malaria parasite strains are resistant to the therapeutic effect of prophylactics
medicines presently available. This resistance now poses a significant challenge to researchers
to beat malaria parasitic infections. Strategies such as investigating newer hybrid chemical
entities and specified drug targets may help us spot new efficient derivatives that bind to the
parasites in a more specific manner and inhibit their growth.

Objective:

To scientifically perform the experimental, pharmacological, and computational studies
of pyrazole-based furanone hybrids as novel antimalarial agents.

Methods:

A series of new furanone-based pyrazole derivatives were synthesized and investigated
as potential antimalarial agents by performing in vitro antimalarial activity. To get further optimization,
these synthesized derivatives were virtually screened based on ADME-T filters, and molecular
docking studies were also accomplished on the crystal structures of Plasmodium falciparum
lactate dehydrogenase (PfLDH). Furthermore, the in-silico prediction was supported by performing
an LDH assay.

Results:

The docking data suggested that the designed hybrid of furanone-pyrazole may act as
PfLDH inhibitors. It was found that the results of experimental in vitro antimalarial activity and in
silico analysis correlate well to each other to a good extent. The compounds (7d), (7g), and (8e)
were found to be the most potent derivatives with IC50 values of 1.968, 1.983, and 2.069 μg/ml, respectively.

Conclusion:

From the results, it may be concluded that compounds that are active in low doses
might be adopted as a lead compound for the development of more active antimalarial agents. The
synthesized compounds (7d), (7g), and (8e) exhibited good antimalarial activity with PfLDH inhibition.
The best compounds can be explored further in the future for designing the potent inhibitors
of PfLDH as new potent antimalarial agents.
Endoplasmic Reticulum Stress and Renin-Angiotensin System Crosstalk in
Endothelial Dysfunction
Authors: Gaikwad Anil Bhanudas , Sankrityayan Himanshu , Rao Pooja Dhileepkumar , Shelke Vishwadeep , Kulkarni Yogesh A. , Mulay Shrikant R.
Published: March 2022

Background:

Vascular endothelial dysfunction (VED) significantly results in catastrophic car-diovascular diseases with multiple aetiologies. Variations in vasoactive peptides, including angiotensin II and endothelin 1, and metabolic perturbations like hyperglycaemia, altered insulin signalling, and homo-cysteine levels result in pathogenic signalling cascades, which ultimately lead to VED. Endoplasmic re-ticulum (ER) stress reduces nitric oxide availability, causes aberrant angiogenesis, and enhances oxidative stress pathways, consequently promoting endothelial dysfunction. Moreover, the renin-angiotensin sys-tem (RAS) has widely been acknowledged to impact angiogenesis, endothelial repair and inflammation. Interestingly, experimental studies at the preclinical level indicate a possible pathological link between the two pathways in the development of VED. Furthermore, pharmacological modulation of ER stress ameliorates angiotensin-II mediated VED as well as RAS intervention either through inhibition of the pressor arm or enhancement of the depressor arm of RAS, mitigating ER stress-induced endothelial dys-function and thus emphasizing a vital crosstalk.

Conclusion:

Deciphering the pathway overlap between RAS and ER stress may open potential therapeu-tic avenues to combat endothelial dysfunction and associated diseases. Several studies suggest that alter-ation in a component of RAS may induce ER stress or induction of ER stress may modulate the RAS components. In this review, we intend to elaborate on the crosstalk of ER stress and RAS in the patho-physiology of VED.
A Review on Structurally Diversified Synthesized Molecules as Monoacylglycerol Lipase Inhibitors and their Therapeutic uses
Authors: Kashyap Abhishek , Kumar Suresh , Dutt Rohit
Published: March 2022

Monoacylglycerol is a metabolic key serine hydrolase engaged in the regulation of the
signalling network system of endocannabinoids, which is associated with various physiological
processes like pain, inflammation, feeding cognition, and neurodegenerative diseases like Alzheimer’s
and Parkinson’s disease. The monoacylglycerol was also found to act as a regulator and
the free fatty acid provider in the proliferation of cancer cells as well as numerous aggressive tumours
such as colorectal cancer, neuroblastoma, and nasopharyngeal carcinoma. It also played an
important role in increasing the concentration of specific lipids derived from free fatty acids like
phosphatidic acid, lysophosphatidic acid, sphingosine-1-phosphate, and prostaglandin E2. These
signalling lipids are associated with cell proliferation, survival, tumour cell migration, contribution
to tumour development, maturation, and metastases. In this study, we present a review on structurally
diverse MAGL inhibitors, their development, and their evaluation for different pharmacological
activities.
Entrepreneurship dexterity and small business success culture in Nigeria
Authors: Anthony Kifordu Anyibuofu , Eneh Sunday Isaac , Effiong Charles , Etuk Idorenyin Udo
Published: March 2022

The study focuses on the effect of entrepreneurship dexterity on small business success culture in Nigeria. The specific objectives are to examine the effect of entrepreneurship innovativeness on small business success culture, determine the effect of entrepreneurship creativity on small business success culture and determine how entrepreneurship risk-taking affect sme accomplishment. The population consists of 100 staff in the selected microfinance banks in three senatorial districts in Delta State. The findings of the study showed that entrepreneurship innovativeness has a significant effect on small business success cultures, entrepreneurship creativity has a significant effect on small business success culture, and entrepreneurship risk-taking has a significant effect on small business success culture. The study concluded that innovativeness influences small business success as innovation will enable the firm to improve on current lines of products, bring into the market new products and use better production techniques or equipment that will enhance productivity. The study recommended that innovativeness dexterities increase the likelihood that a firm will realize first-mover advantage and capitalize on emerging market opportunities and generate extraordinary economic performance.
Температурная зависимость уровня Ферми в узкозонных объемных пленках HgCdTe при различной концентрации вакансий ртути
Authors: Козлов Д.В. , Жолудев М.С. , Румянцев В.В. , Иконников А.В. , Pavlov S. , Hubers H.-W. , Морозов С.В.
Published: March 2022

Выполнен анализ положения уровня Ферми в объемном HgCdTe с долей кадмия от 19 до 22% в зависимости от температуры для различных концентраций вакансий ртути, формирующих двухзарядные акцепторы с энергиями ионизации 11 и 21 мэВ для нейтрального и однократно заряженного состояний соответственно. Рассчитана концентрация свободных носителей в зонах при различных температурах, а также доля акцепторных центров в различных зарядовых состояниях. Полученные результаты объясняют быстрое температурное гашение фотопроводимости, обусловленной вакансиями ртути, и показывают, что в материале p-типа в зависимости проводимости от температуры может возникать участок экспоненциального роста с характерной энергией значительно больше половины ширины запрещенной зоны при нулевой температуре, как это можно было бы ожидать из закона действующих масс для собственного полупроводника. Ключевые слова: узкозонные полупроводники, HgCdTe, уровень Ферми, двухзарядные акцепторы.
Сравнительный анализ эффективности электролюминесценции в гетероструктурах I и II типа на основе узкозонных соединений А-=SUP=-III-=/SUP=-B-=SUP=-V-=/SUP=-
Authors: Баженов Н.Л. , Мынбаев К.Д. , Семакова А.А. , Зегря Г.Г.
Published: March 2022

A detailed analysis of the mechanisms of radiative and
Auger recombination in type I and II heterostructures based on
narrow-gap AIIIBV materials is presented. It is shown that the
presence of a heterointerface fundamentally changes the nature of
these recombination processes differently, depending on the type
of heterojunction. Results of our study of the electroluminescence
of type I and II LED heterostructures based on InAs(Sb)/InAsSbP
quantum wells are presented. It is shown that the increase in
relative efficiency of radiative recombination in type II heterostructures
due to suppression of Auger recombination contributes to
generation of stimulated emission in these heterostructures at low
temperatures (4.2−70K).
Влияние условий формирования кремниевых диодов на их обратные токи
Authors: Булярский С.В. , Кицюк Е.П. , Лакалин А.В. , Сауров М.А. , Светухин В.В. , Орлов А.П. , Рудаков Г.А.
Published: March 2022

In this work, a study was made of the influence of silicon diode manufacturing technology on the emergence of generation and recombination centers. The electrical characteristics of p-n junctions formed in different ways on n-type silicon substrates were compared: a) the p-type layer was created by the diffusion method; b) the p-type layer was formed by ion implantation into an epitaxial n-layer preliminarily grown on the substrate; c) two n- and p-type epitaxial layers were successively deposited on the substrate. It has been established that for diodes based on a double epitaxial layer, the direct and reverse current-voltage characteristics (CVC) are due to the diffusion mechanism, and the structures themselves have a low concentration of recombination centers. At the same time, in diodes based on the diffusion method and ion implantation, the CVCs are due to the generation-recombination mechanism. With reverse bias, electron-phonon processes play a significant role in the formation of the CVC, and with forward bias, carrier recombination in the region of the space charge of the p-n junction. The concentrations and energies of recombination centers have been determined.
Impact of the COVID-19 Pandemic on Dermatology Practice Worldwide: Results of a Survey Promoted by the International Dermoscopy Society
Authors: Conforti Claudio
Published: March 2022

Background

The International Dermoscopy Society (IDS) conducted an online survey to investigate the impact of the COVID-19 outbreak on the daily practice of dermatologists working with patients with skin cancer, to collect data regarding the frequency of skin manifestations noticed by the members, and to obtain information about the use of teledermatology during the pandemic.

Objective

The aims of this study are to identify changes within dermatology departments during lockdowns, to evaluate the use of teledermatology during the COVID-19 pandemic, and to find the most frequent cutaneous manifestations associated with COVID-19.

Methods

All IDS members (approximately 160,000 members) were asked to fill in a questionnaire sent by email. The questionnaire was available in English and was anonymous, with a compiling time of less than 5 minutes. The survey was open for 30 days (from April 24, 2020, to May 24, 2020) and it could only be filled out once.

Results

Overall, 678 dermatologists responded to the questionnaire; of these, 334 members stated that there had been a reduction of more than 75% in daily work activity during the pandemic, 265 dermatologists worked fewer days per week, and 118 experienced telemedicine for the first time. Acrodermatitis was the most frequently observed skin manifestation (n=80), followed by urticarial rash (n=69), morbilliform rash (n=53), and purpuric manifestation (n=40). Regarding the role of teledermatology, 565 dermatologists reported an increased number of teleconsultations, and the number of melanomas diagnosed during the pandemic was practically 0 for 385 (56.8%) respondents.

Conclusions

This survey highlights that the outbreak had a negative impact on most dermatology services, with a significant reduction in consultation time spent for patients with chronic conditions, and an increased risk of missed melanoma and nonmelanoma skin cancer diagnosis. Moreover, our study confirms earlier findings of a wide range of skin manifestations associated with COVID-19.

Conflicts of Interest

None declared.
Confocal Microscopy and its Role in Teledermatology: Diagnosis of Basal Cell Carcinoma in a Clinical Setting
Authors: Garfinkel Jason , Chandler C , Rubinstein G , Jain Manu
Published: March 2022

Background

Reflectance confocal microscopy (RCM) is a noninvasive tool that is used to diagnose skin cancers. However, RCM requires an expert consultation, which is often performed via store-and-forward (SAF) teledermatology. Unfortunately, SAF does not mimic bedside diagnosis, nor permits interaction between the remote expert reader, physician, and patient. Recently, a live interactive method (LIM)–tele-RCM approach was shown to diagnose basal cell carcinoma (BCC) from a remote location, demonstrating advantages over SAF by providing a bedside diagnosis during consultation.

Objective

The aim of this study is to validate the LIM-tele-RCM approach to diagnose BCC in a real-world setting.

Methods

In this pilot study, 4 patients with 6 clinically suspicious BCC lesions were enrolled and imaged with RCM at a Los Angeles dermatology clinic. A Health Insurance Portability and Accountability Act–compliant teleconferencing application was used to livestream RCM images to an expert RCM reader in New York. The expert reader had remote control of the software, direct audio communication with the clinic, and the patient’s clinical history with dermoscopy. During imaging, RCM features were noted, and a diagnosis was made at the bedside. After imaging, patients completed a short questionnaire (on a 5-point scale, with 5 being the highest score) about satisfaction, comfort, and communication during the session. 

Results

RCM diagnosed 4/6 (67%) lesions correctly as BCC and 2/6 (33%) were false-positive diagnoses. The true-positive lesions had “tumor islands with palisading and clefting” and were directly managed with Mohs surgery. The false-positive lesions had “dark silhouettes” (a common false-positive feature for BCC) and underwent a shave biopsy for confirmation. The entire session ranged from 15 to 20 minutes (an average of 17.7 minutes), comparable to the reported RCM procedure time. On the questionnaire, all patients responded with the highest rating (5/5) for each question.

Conclusions

LIM-tele-RCM demonstrates potential advantages over the SAF method, enabling bedside diagnosis with similar diagnostic accuracy as reported in the literature and proper management. Additionally, the remote reader had access to patients’ clinical backgrounds and could engage with patients. It may also be useful for training novice RCM users and beneficial in settings where remote diagnostics are desired, such as during the COVID-19 pandemic. However, technical challenges such as image quality degradation during video streaming, poor internet bandwidth, and end user latency may impact diagnosis. Larger, multicenter studies are needed to assess the accuracy of LIM-tele-RCM for the diagnosis of BCC and other neoplastic and inflammatory lesions, and to quantify technical limitations.

Acknowledgments

This work was funded by the National Cancer Institute Cancer Center (Grant P30 CA008748).

Conflicts of Interest

None declared.
Confocal Microscopy and its Role in Teledermatology: Diagnosis of Basal Cell Carcinoma in a Clinical Setting (Preprint)
Authors: Garfinkel Jason , Chandler C , Rubinstein G , Jain Manu
Published: March 2022

BACKGROUND

Reflectance confocal microscopy (RCM) is a noninvasive tool that is used to diagnose skin cancers. However, RCM requires an expert consultation, which is often performed via store-and-forward (SAF) teledermatology. Unfortunately, SAF does not mimic bedside diagnosis, nor permits interaction between the remote expert reader, physician, and patient. Recently, a live interactive method (LIM)–tele-RCM approach was shown to diagnose basal cell carcinoma (BCC) from a remote location, demonstrating advantages over SAF by providing a bedside diagnosis during consultation.

OBJECTIVE

The aim of this study is to validate the LIM-tele-RCM approach to diagnose BCC in a real-world setting.

METHODS

In this pilot study, 4 patients with 6 clinically suspicious BCC lesions were enrolled and imaged with RCM at a Los Angeles dermatology clinic. A Health Insurance Portability and Accountability Act–compliant teleconferencing application was used to livestream RCM images to an expert RCM reader in New York. The expert reader had remote control of the software, direct audio communication with the clinic, and the patient’s clinical history with dermoscopy. During imaging, RCM features were noted, and a diagnosis was made at the bedside. After imaging, patients completed a short questionnaire (on a 5-point scale, with 5 being the highest score) about satisfaction, comfort, and communication during the session. 

RESULTS

RCM diagnosed 4/6 (67%) lesions correctly as BCC and 2/6 (33%) were false-positive diagnoses. The true-positive lesions had “tumor islands with palisading and clefting” and were directly managed with Mohs surgery. The false-positive lesions had “dark silhouettes” (a common false-positive feature for BCC) and underwent a shave biopsy for confirmation. The entire session ranged from 15 to 20 minutes (an average of 17.7 minutes), comparable to the reported RCM procedure time. On the questionnaire, all patients responded with the highest rating (5/5) for each question.

CONCLUSIONS

LIM-tele-RCM demonstrates potential advantages over the SAF method, enabling bedside diagnosis with similar diagnostic accuracy as reported in the literature and proper management. Additionally, the remote reader had access to patients’ clinical backgrounds and could engage with patients. It may also be useful for training novice RCM users and beneficial in settings where remote diagnostics are desired, such as during the COVID-19 pandemic. However, technical challenges such as image quality degradation during video streaming, poor internet bandwidth, and end user latency may impact diagnosis. Larger, multicenter studies are needed to assess the accuracy of LIM-tele-RCM for the diagnosis of BCC and other neoplastic and inflammatory lesions, and to quantify technical limitations.
Aplikasi Silika Sebagai Amelioran Air Salin Limbah Budidaya Ikan Kerapu Terhadap Pertumbuhan Dan Hasil Mentimun (Cucumis sativus L.) Hidroponik
Authors: Nurbaeti Muflikhatun , Kurniasih Budiastuti
Published: March 2022

Kebutuhan pangan bagi manusia seperti sayuran semakin meningkat seiring perkembangan jumlah penduduk, sehingga perlu adanya produksi untuk mencukupi kebutuhan tersebut. Salah satu teknologi budidaya yang dapat dikembangkan yaitu produksi mentimun dengan memanfaatkan air salin limbah kerapu dan aplikasi amelioran silika secara hidroponik. Penelitian ini bertujuan untuk menentukkan pengaruh salinitas air limbah budidaya ikan kerapu dan pengaruh dosis silika terhadap pertumbuhan dan hasil mentimun yang dibudidayakan secara hidroponik. Penelitian ini dilakukan di Kebun Percobaan milik PT INDMIRA di Jalan Kaliurang km 19 pada bulan Maret - Juni 2018. Penelitian ini disusun dalam rancangan acak kelompok lengkap faktorial (3 x 3 + 1) dengan faktor pertama berupa konsentrasi air salin limbah budidaya ikan kerapu yang terdiri dari 3 aras yaitu 3 dS/m (U1), 6 dS/m (U2), dan 9 dS/m (U3), dan faktor kedua berupa dosis silika yang terdiri dari tiga aras yaitu 50 ppm (P1), 100 ppm (P2), dan 150 ppm (P3). Kontrol digunakan tanaman mentimun yang tidak diberi air salin limbah budidaya ikan kerapu dan silika. Hasil penelitian menunjukkan bahwa pemberian salinitas air limbah budidaya ikan kerapu pada kisaran konsentrasi 3 dS/m – 9 dS/m meningkatkan bobot kering akar. Aplikasi silika dengan dosis 50 ppm, 100 ppm dan 150 ppm meningkatkan  bobot kering tajuk, kadar air nisbi. Dosis silika 100 ppm menunjukkan hasil klorofil yang paling tinggi dan meningkatkan rasio akar/tajuk. Aplikasi silika pada dosis 50 ppm dan 100 ppm pada salinitas 6 dS/m menunjukkan hasil ton/ha yang paling tinggi.
Tanggapan Kangkung Darat (Ipomoea reptans Poir.) Terhadap Monosodium Glutamat (MSG) Berbagai Konsentrasi
Authors: Nugroho Syam Widi , Kastono Dody
Published: March 2022

Pertambahan penduduk mendorong peningkatan kebutuhan pangan dan huga gizi salah satunya melalui tanaman sayuran. Kangkung merupakan salah satu tanaman yang digemari masyarakat dan memiliki umur pendek dan kandungan gizi yang cukup tinggi. Penelitian dilaksanakan untuk mengetahui tanggapan pertumbuhan dan hasil tanaman kangkung darat (Ipomoea reptans Poir.) dengan pemberian beberapa konsentrasi monosodium glutamat. Penelitian dilakukan di Rumah Kawat, Fakultas Pertanian, Universitas Gadjah Mada, Yogyakarta pada bulan April-Mei 2019. Penelitian disusun dengan rancangan acak lengkap dan perlakuan berupa konsentrasi monosodium glutamat yang terdiri dari 0,5 g/l, 1 g/l, dan 1,5 g/l. Sebagai kontrol digunakan konsentasi 0 g/l. Metode yang digunakan adalah pengukuran kuantitatif beberapa parameter, kemudian dimasukkan dalam rumus perhitungan analysis of variance (ANOVA) dan uji lanjut menggunakan duncan’s multiple range test (DMRT). Hasil penelitian menunjukkan mulai pemberian monosodium glutamat 1 g/l mampu meningkatkan tinggi tanaman (14,13%), jumlah daun (28,85%), bobot segar total (84,21%), bobot segar tajuk (109,25%), bobot kering total (50,61%), bobot kering tajuk (94,84%), dan luas daun (114,011%) dibanding kontrol pada 35 hari setelah tanam.
Respons Pertumbuhan dan Kadar Kapsaisin Tanaman Cabai Merah (Capsicum annuum L.) terhadap Kekeringan dan Pemberian Mikoriza Arbuskular
Authors: Utari Dewi , Rachmawati Diah
Published: March 2022

Kondisi iklim dan unsur hara sangat berpengaruh pada produksi cabai merah (Capsicum annuum L.). Ketersediaan unsur hara dipengaruhi oleh beberapa faktor salah satunya yaitu mikoriza. Mikoriza membantu tanaman dalam penyerapan air dan unsur hara. Penelitian ini bertujuan untuk mempelajari respons pertumbuhan tanaman cabai merah (Capsicum annuum L.) dan kadar kapsaisin buah cabai terhadap interval penyiraman dan pemberian mikoriza. Penelitian Ini menggunakan metode eksperimental dengan rancangan acak lengkap (RAL) yang terdiri atas dua faktor yaitu interval penyiraman dan pemberian mikoriza. Perlakuan interval penyiraman terdiri atas 2 kelompok yaitu penyiraman setiap hari dan tiga hari sekali. sedangkan perlakuan pemberian mikoriza terdiri atas 3 kelompok yaitu tanpa pemberian mikoriza, mikoriza 10 g/tanaman dan 15 g/tanaman. Parameter yang diamati yaitu tinggi tanaman, jumlah daun, kadar klorofil, jumlah buah, berat buah dan kadar kapsaisin buah cabai. Data yang diperoleh kemudian dianalisis menggunakan analisis variansi dan pengujian lanjut DMRT dengan α = 0,05. Hasil yang diperoleh yaitu kombinasi perlakuan mikoriza+interval penyiraman berpengaruh nyata terhadap jumlah daun, kadar klorofil, jumlah buah, berat buah dan kadar kapsaisin buah. Pemberian mikoriza meningkatkan kadar kapsaisin baik pada interval penyiraman setiap hari maupun tiga hari sekali. Interval penyiraman setiap hari menunjukkan berat buah lebih tinggi daripada interval penyiraman 3 hari sekali, namun kadar kapsaisin yang lebih rendah.  Berdasarkan hasil penelitian yang telah dilakukan  dapat disimpulkan bahwa perlakuan pemberian mikoriza 15g+interval penyiraman setiap hari menunjukkan hasil tertinggi pada jumlah daun, tinggi tanaman, jumlah buah, berat buah, serta kadar klorofil daun.
Bakassi Women in Cross-Border Trade with Nigeria (1963 to 2016): Motivations and Constraints
Authors: Théodore Ngoufo Sogang , Abigail Ebai Bakow
Published: March 2022

Bakassi, a peninsula rich in petroleum and natural gas, is Cameroon’s, after a lingering border dispute over it with Nigeria which saw Cameroon emerging triumphant. As expected, a large extent of the peninsula’s historiography has been pretty conflict-based than otherwise. It is within this basis that the underlying article explores yet an existent but casually exploited field – the experience of cross-border trade in the peninsula. Likewise, Cameroon’s reluctant enthusiasm to make gender-equalized evaluations of trade inspired the spotlight of this research on the female gender. It is in this light that the write-up aims at delving into the reasons why the women of Bakassi (in the Cameroon side), ventured into cross-border trade with Nigeria between the years 1963 and 2016 as well as the different constraints witnessed in doing so. Relying on primary and secondary sources while consuming other disciplines where indispensable, the article depended on the thematic, chronological and descriptive models of analysis accordingly. From the objectives and methods adapted, the results of our findings proved that during the years under reflection, historical relationships, intermarriages, differences in natural resource base, differences in prices, devaluation of the Nigerian currency and the economic crisis of the 1980s all motivated Bakassi women to undertake the trade. As for the obstacles faced in the process, they varied from the economic standpoint to socio-cultural restrains. The economic hindrances included corruption, piracy, theft, fraud, price instability, transport and communication network problems and inadequate capital while the socio-cultural obstructions were mainly illiteracy, inadequate access to information and traditional prejudices.
Turismo comunitario y patrimonio cultural desde la percepción de los residentes: Zacualpan de Amilpas, Morelos
Authors: García Aguilar Gloria Guadalupe , Serrano-Barquín Rocío del Carmen , Palmas-Castrejón Yanelli Daniela , Ramírez-Hernández Omar Ismael
Published: March 2022

Objetivo: analizar la percepción que tiene la comunidad de Zacualpan de Amilpas (México) sobre el turismo y sobre su patrimonio, para saber cuáles son los efectos de dicha actividad recreativa en las dimensiones económica, ecológica y sociocultural, a las que se incorpora, como resultado de la investigación, la política. Metodología: investigación cualitativa en dos etapas: entrevistas y observación participante en la comunidad y etnografía remota mediante entrevistas. El análisis se realizó a partir de la teoría de las representaciones sociales. Resultados: se confirma el interés en el turismo como alternativa de desarrollo debido a sus beneficios económicos. Además, se detectó la necesidad del cuidado del patrimonio. Limitaciones: es necesario combinar otras técnicas de recolección. Valor: se identificaron las funciones de las representaciones sociales: entendimiento de la percepción de la comunidad, la importancia de la identidad cultural, los comportamientos y las prácticas frente al turismo. Conclusiones: se consignaron dos tipos de representaciones sociales a partir de la percepción: hegemónicas (importancia económica) y emancipadas (interés en proteger los recursos de la comunidad).
De Guido Guinizzelli a Dante Alighieri. Una mirada filosófica al capítulo XX de la Vita nova o del origen del “Amor, ch’a nullo amato amar perdona”
Authors: García-Salas Víctor
Published: March 2022

Our intention here is to analyse chapter XX from Vita nova and draw how it leads into Canto V of the Commedia. Nevertheless, as in this chapter, and in general the Dolce stil novo, has a crucial precedent in Guido Guinizzelli’s canzone, “Al cor gentil rempaira sempre amore” [To the noble heart always returns love]. It will be our first task to analyse this canzone, its load of “philosophical” arguments and its doctrinal content (the doctrine of love). Consequently, evidence of a clear line that goes from Guinizzelli to Dante will be shown, as well as the evolution in the quality of the arguments and how this doctrine converges to Paolo and Francesca, in Canto V from Inferno.
La traducción como metáfora
Authors: Álvarez-Mejía Diana
Published: March 2022

Walter Benjamin, in 1923, wrote “The Task of the Translator”, in which he describes the translator’s endeavour and argues that this task is more complex than the quest of equivalence between two texts. Meanwhile, Emmanuel Levinas, in his 1962 lecture “The Metaphor”, claims that, when it comes to metaphorizing, one must look beyond similarity. From both visions, this essay intends to show how these two authors have had common ground on their conception of language, its evolution, and the mystery it holds. And proposes that the translation of literary works finds its foundation in the metaphor to account for the difference of each language as otherness, and how the translator must allow himself or herself to be destabilized by the foreign language, to give survival to the original, and, simultaneously aim for an ethic of the other in their task.
Christina Rossetti (1830-1894). Poemas. Selección y versión al español de Hernán Bravo Varela
Authors: Bravo-Varela Hernán
Published: March 2022

Christina Rossetti’s poems (1830-1894) in a selection and version by Hernán Bravo Varela
Isolation of Sponge Bacterial Symbionts from Kodingareng Keke Island-Makassar Indonesia Which is Potential as a Producer of Antimicrobial Compounds
Authors: Rante Herlina , Alam Gemini , Usmar Usmar , Anwar Rhezky Awalia , Ali Alimuddin
Published: March 2022

Sponge is an invertebrate animal in the Porifera phylum, which potentially produces bioactive compounds that are known as potential agents in producing antimicrobial compounds. This research aims to determine the antimicrobial activity of bacteria isolates obtained from the samples of the sponge of Kodingareng Keke Island-Makassar Indonesia. Samples were isolated by the pour plate method using NA (Nutrient Agar) media and incubated for 1 x 24 hours. A total of 8 bacteria were isolated with code KDR-02-01, KDR-02-02, KDR-02-03, KDR-02-04, KDR-02-05, KDR-02-06, KDR-02-07, KDR-02-08, KDR-02-09 and KDR-02-10. Each isolate of bacteria is purified by using quadrant streaks method until it is obtained by a pure isolate bacteria followed by an antagonistic test. From the antagonist test, bacteria KDR-02-07 continue to be fermented because they have the best inhibition compared to other isolates capable of inhibiting E. coli, S. aureus and C. albicans. Active isolate fermented for 8 days to produce secondary metabolite. After fermentation of 8 days the fermentation medium was separate by filtration then supernatant was extraction using ethyl acetate (1:1) and biomass macerated using methanol. Ethyl acetate extracts and methanol extracts that have been obtained are continued on antimicrobial activity test with diffusion method in order to microbial test microbes E. coli, S. aureus, B. subtilis, C. albicans and A. niger. The results of the study showed that ethyl acetate extract in concentration of 10% can inhibit E. coli and B. subtilis, in concentration of 5% inhibit B. subtilis and in concentrations of 1.25% inhibit A. niger, whereas in methanol extracts not acquired antimicrobial activity. Based on the results of a microscopic test it was obtained that the bacteria were isolated is Gram-positive and basil bacteria.
Strength Evaluation and Durability on Addition of Nanosilica in M30 Grade Concrete
Authors: Srinivas Bangaru Sai , Raju K.V.V. Rama
Published: March 2022

Abstract: Nano technology plays a very vital role in all the areas of research. The incorporation of nano materials in concrete offers many advantages and improves the workability, the strength and durability properties of concrete. In this study an attempt has been made to carry out an experimental investigation on concrete in which cement was replaced with nano sized cement. Nano-silica has a unique advantage in the potential pozzolanic-reaction with cement hydration products over other nanoparticles. Addition of Nano-silica is known to redefine pore size and distribution which would alter the durability of the concrete. Ordinary Portland cement of 53 grade was ground in a ball grinding mill to produce nano cement. . Nano technology is an emerging field of interest for civil engineering utility. A few of the nano substances presently used in concrete, nano-silica very own greater pozzolanic nature. It has the functionality to react with the unfastened lime inside the route of the cement hydration and bureaucracy extra C-S-H gel giving strength, impermeability and durability to concrete. Present paper investigates the effects of addition of nano silica in normal strength of concrete. The present research deals with Partial alternative cement through nano silica powder as partial replacements in concrete at associate with various materials like OPC53 grade cement, fine aggregate, coarse aggregate to check their suitability for making concrete. The mix proportions of concrete were modified as micro silica (5%, 7.5%, 10%, 15%) and nano silica (1%, 1.5%, 2%, 2.5%) as partial replacement of cement. The cubes were cast by replacing Specimens were cast as per mix design and the tests are conducted after proper curing, the tests are compressive strength of cubes (150mm x 150mm x 150mm) and split tensile strength of cylinders (150mm x 300mm). The results had been compared with the outcomes of concrete specimens with 0% of nano silica. Keywords: M30 grade, nano silica, Nano technology,pozzolanic-reaction
Review of Rossiya na poroge informatsionnykh voin. Politika rossiiskogo pravitel'stva v sfere SMI v nachale XX veka by E.G. Kostrikova. St. Petersburg: Petroglif Publ., 2020. 352 p.
Authors: Shpakovskaya Marina A.
Published: March 2022

-
The Provisional Government and “Chinese Question” in Russia in 1917
Authors: Khodjakov Mikhail V. , Yizhi Sun
Published: March 2022

The article analyzes the changes that took place during the solution of the so-called Chinese question on the basis of the journals of the Interdepartmental Consultation under the board of the Chinese Eastern Railway, which have been preserved in the Russian State Historical Archive. The peak of activity in this direction first of the tsarist government, and then of the Provisional government was from the second half of 1916 to the autumn of 1917. Documents show that the labor of recruited Chinese workers was used in many sectors of the economy. But the most important it received in the railway construction. Russia's military operations had slowed down the colonization of the Far East. Under these conditions, the arrival of tens of thousands of Chinese workers in the European part of the country became a peculiar reflection of the eastern direction of Russia's domestic and foreign policy. The attitude toward this phenomenon in social and political circles has changed since the formation of the Provisional Government. While pursuing the course of tsarism in solving the problem of the crisis of workers' hands, the Provisional Government simultaneously made a number of concessions to the Chinese mission in Petrograd. In particular, its representatives were given the opportunity to become acquainted with the working and living conditions of the Chinese workers. Rising unemployment and protest moods in Russian society eventually forced the Provisional Government, shortly before its fall, to abandon the transportation of foreign laborers to Russia.
No salão do Brega
Authors: Dos Santos Coelho Flávia , Vieira Magalhães Lilian
Published: March 2022

Refletir sobre a produção de conhecimento científico envolve refinar estratégias metodológicas que visem superar estruturas de poder impostas. Nesse sentido, os estudos-piloto caracterizam-se como versões mais curtas de um projeto de pesquisa completo, que em geral visam prevenir problemas e aprimorar o desenho metodológico por meio do teste de métodos, técnicas e instrumentos de pesquisa, bem como preparar o pesquisador, especialmente o iniciante, pelo desafiador trabalho com pesquisa qualitativa. A literatura sobre a utilização de estudos-piloto ainda é escassa e, quando realizados, muitas vezes não atinge os desafios e a curva de aprendizado do pesquisador. Assim, buscamos problematizar os procedimentos do estudo piloto, situando-o como um importante recurso para a pesquisa qualitativa. Um projeto piloto para preparar o trabalho de campo de pesquisa de mestrado, de natureza etnográfica, foi realizado a partir do fenômeno das festas de Baile da Saudade, mediante a pergunta: Que estratégias, técnicas e procedimentos podem garantir maior eficácia em pesquisa qualitativa de natureza etnográfica? Dois atores principais que compõem as festas de Baile da Saudade participaram do estudo por meio de entrevista semiestruturada e método Photovoice. Com a execução do projeto piloto, percebemos que as estratégias que superam as relações hierárquicas entre pesquisador e participante são necessárias para garantia do processo participativo e, consequentemente, maior eficácia em abordagens qualitativas de natureza etnográfica.
Práticas de democratização da literatura
Authors: Oliveira Lucas , Souza Bruna , Dorea Isabelle , Araújo Laura
Published: March 2022

O texto se debruça sobre algumas cartoneras latino-americanas, editoras que produzem e difundem livros artesanais, confeccionados e pintados à mão, a partir da reciclagem de materiais coletados por cooperativas de catadores urbanos. A partir de etnografia digital, o objetivo do artigo é analisar redes de atuação estabelecidas entre cartoneras de diferentes países, abordando-as como parte de um movimento cultural transnacional que, por um lado, propõe formas alternativas de produzir e distribuir livros em espaços não institucionalizados e, por outro, incentiva a transformação de objetos "não artísticos" em arte. Busca-se verificar em que medida o potencial de criatividade artística colocado em prática pelas cartoneras tem sido responsável por um processo de democratização de práticas editoriais e literárias na América Latina. Na primeira parte, descrevemos os desafios metodológicos de uma pesquisa coletiva em meio à pandemia da Covid-19, delimitando nosso recorte empírico e as ferramentas usadas ao longo da etnografia digital. Em seguida, tratamos de duas estratégias que agentes têm utilizado para fazer frente a um modelo de produção editorial e literária que, para elas/es, é excludente, notadamente as suas redes de atuação e as rotinas coletivas de trabalho. Por fim, nos debruçamos sobre o “livro-objeto”, a partir de uma discussão sobre contra-usos do papelão como forma de ampliar práticas de democratização do acesso ao livro, à leitura e à literatura.
revolução leitora entre os séculos XX e XXI e os atratores visuais de Frida Kahlo
Authors: SILVEIRA Mariane Rocha , Campigotto Aquino Ivânia
Published: March 2022

O presente artigo científico, de caráter qualitativo e descritivo, tem como objetivos principais apresentar um recorte sobre o contexto histórico-social, a vida e a obra da artista mexicana Frida Kahlo, assim como realizar uma análise dos elementos visuais que atraíram diferentes leitores a partir de uma perspectiva teórica distinta da fortuna crítica que ora se apresenta sobre a pintora. Para isso, conta-se, como fundamentação teórica, com os estudos de Canevacci (2008), em relação aos atratores visuais, e de Santaella (2004, 2013), que colabora por meio da definição quanto aos tipos de leitores que se desdobram entre os séculos XX e XXI. Para a reconstrução histórica do México e da biografia de Frida, o estudo baseia-se nas produções de Fernández (2002), Florencio (2014), Henestrosa (2012), Herrera (2011), Kettenmann (2015) e Zamora (2007). Os resultados parciais, já que o estudo se encontra em andamento, apontam que Frida Kahlo, como bodyspace, criou um dress-code, ou seja, um estilo próprio com base em suas raízes histórico-sociais e em sua location; e, com isso, atraiu os olhares daqueles que não estavam acostumados à semiótica impressa por ela.
STRATEGI COPING STRESS SINGLE MOTHER DI KOTA JAMBI
Authors: Hapsari Anggita Wahyu , Urbayatun Siti
Published: March 2022

Tujuan penelitian ini adalah untuk mengetahui gambaran bentuk-bentuk strategi coping stress single mother di Kota Jambi dan faktor-faktor yang mempengaruhi strategi coping stress single mother di Kota Jambi. Metode penelitian yang digunakan adalah kualitatif dengan pendekatan fenomenologi dengan lima partisipan yang dipilih sesuai dengan karakteristik penelitian. Teknik pengumpulan data yang digunakan adalah wawancara semiterstruktur dan observasi. Hasil penelitian menunjukkan bahwa empat partisipan yaitu JV, CT, FR dan PG menggunakan kedua bentuk strategi coping stress baik emotion focused coping maupun problem focused coping sedangkan satu partisipan yaitu ML hanya menggunakan satu bentuk strategi coping stress berupa emotion focused coping. Sementara itu, faktor yang mempengaruhi strategi coping stress dirasakan oleh tiga partisipan dan dua partisipan tidak merasa dipengaruhi faktor tersebut adalah dukungan sosial. Kesimpulannya bahwa dari lima partisipan hanya empat yang menggunakan dua bentuk strategi coping stress sedangkan satu partisipan menggunakan satu strategi coping stress. Dan dari lima faktor yang mempengaruhi strategi coping stress ada tiga partisipan yang merasakan pengaruhnya dan dua partisipan lagi tidak merasakan pengaruhnya
PENGARUH SISTEM ANTRIAN BERBASIS QUICK RESPONSES CODE TERHADAP BEBAN KERJA PETUGAS LOKET PENDAFTARAN DI RUMAH SAKIT SURYA HUSADHA DENPASAR
Authors: Wasita Rai Riska Resty , Susanto Agus Donny
Published: March 2022

Berdasarkan data tahun 2020, rata-rata kunjungan pengguna asuransi Badan Penyelenggara Jaminan Sosial (BPJS) Kesehatan di Rumah Sakit Surya Husadha Denpasar berkisar 6000 kunjungan per bulannya sehingga sering terjadi penumpukan antrian di loket pendaftaran pasien. Hal ini secara tidak langsung menambah beban kerja petugas loket yang harus menginput data pasien satu per satu secara manual. Tidak jarang terjadi kelelahan sehingga menurunkan kinerja serta menambah tingkat kesalahan petugas. Tujuan penelitian ini untuk mengidentifikasi pengaruh sistem antrian berbasis QR code terhadap beban kerja petugas loket pendaftaran di rumah sakit. Penelitian ini merupakan penelitian kuantitatif dengan pendekatan quasi eksperimen one group prettes-posttes. Pengambilan sampel dilakukan pada 20 petugas loket pendaftaran BPJS dengan menggunakan teknik sampling jenuh. Pengembangan sistem QR code menggunakan System Development Life Cycle (SDLC). Pengumpulan data dilakukan dengan menyebarkan kuesioner sebelum dan setelah petugas diberikan intervensi QR Code. Analisis yang digunakan yaitu uji Paired T-tes untuk melihat pengaruh QR Code terhadap beban kerja petugas sebelum dan setelah diberikan QR Code. Hasil penelitian menunjukkan hasil pre test dan post test beban kerja diperoleh nilai signifikansi (p-value) sebesar 0,002 yang bermakna bahwa terdapat perbedaan yang signifikan antara rata-rata beban kerja pre-test dan post-test setelah penggunaan sistem atrian berbasis QR Code
HUBUNGAN PERUBAHAN POLA BELAJAR TERHADAP STRES DAN PRESTASI AKADEMIK PADA MASA PANDEMI COVID-19
Authors: Wieka Annatasya Cindy , Kartika Ajeng Afni , Masdalena Masdalena , Handoko Erwin
Published: March 2022

Di bidang pendidikan kedokteran, pola belajar yang diterapkan pada saat ini berpotensi menimbulkan stres pada mahasiswa. Fakultas Kedokteran di Indonesia menganut cara pembelajaran berbasis masalah (problem-based learning) yang terpusat pada mahasiswa (student-centered learning). Proses pembelajaran yang terpusat pada mahasiswa dalam kegiatan belajar dan mengajar tersebut, bila tidak dikelola dengan tepat akan mengakibatkan stres berlebih yang pada akhirnya memengaruhi kemampuan belajar dan prestasi akademik mahasiswa. Karena itu, penelitian ini bertujuan untuk mempelajari apakah terdapat perubahan yang berarti pada pola belajar dan hubungannya terhadap stres serta prestasi akademik pada mahasiswa kedokteran. Dilakukan penelitian cross-sectional terhadap 193 mahasiswa/i fakultas kedokteran Universitas Prima Indonesia. Adapun parameter yang diukur dalam penelitian ini meliputi: pola belajar, tingkat stres, prestasi akademik dan hubungan antara perubahan pola belajar, stres dan prestasi akademik. Penelitian ini menggunakan metode analisis uji korelasi Pearson dan mendapati hasil bahwa 184 dari 193 orang mahasiswa/i fakultas kedokteran Universitas Prima Indonesia memiliki tingkat stres normal, 167 mahasiswa/i merasakan terdapat perubahan pola belajar selama berkuliah daring dan ditemukan hubungan yang signifikan antara tingkat stres dan pola belajar strategi deep serta stres dan prestasi akademik. Dapat disimpulkan bahwa terdapat hubungan antara perubahan pola belajar strategi deep dengan stres dan stres dengan prestasi akademik mahasiswa/i Universitas Prima Indonesia.
PURIFIKASI MINYAK GORENG BEKAS DENGAN PROSES ADSORBSI MENGGUNAKAN ARANG KULIT KACANG TANAH (ARACHIS HYPOGAEA L.)
Authors: Mardiana Mardiana , Santoso Tri
Published: March 2022

Absorbents have been widely used in purification of used cooking oil to improve the oil quality. This study aimed to determine the quality of used cooking oil after adsorbed using activated charcoal from peanut shells based on the best purification time in accordance with SNI 01-3741-1995. Oil quality parameters used are color, free fatty acid content, peroxide number, iodine number, water content, and oil density. The best results were obtained at 120 minutes purification time with an absorbance value of 0.023 A, free fatty acid content of 0.22%, peroxide number of 1.83 meq/kg, iodine number of 43.40, moisture content of 0.19% and oil density of 0.924 g/mL Only iodine number and oil density from the six parametersthat have not yet met the SNI cooking oil quality requirements.
PEMANFAATAN SERBUK GERGAJI SEBAGAI BAHAN BAKU BRIKET
Authors: Sari Pratiwi Nova , Aminah Sitti
Published: March 2022

Wood sawdust is one of the wastes from wood processing industry such as sawdust and peel residues. They are cheap raw materials and potential as a source of alternative energy by processing it into charcoal briquettes. The use of charcoal briquettes as a substitute for fossil energy sources has several advantages including the relatively less smoke emitted because it has been released during the carbonization process. They can be stored for a long time and the calor value is higher than wood. Charcoal briquettes are made from wood sawdust which is added by tapioca flour as glue. This study was conducted in two main stages, processing charcoal briquette and characterization. The characterization of charcoal briquettes are including density, moisture, ash, volatile substances levels, carbon bound, long flame and calor value. The results obtained from the charcoal briquettes are a density of 0.384 gr/cm3, a moisture of 2.44%, an ash of 4.82%, a volatile substance of 19.13%, a carbon bond of 74.44%, a briquette flame of 6.75 minutes/gr and the calor value of 5127 cal/gr. This study concluded that wood sawdust briquette has the potential to be used potentially as substitued for fuel.
ANALISIS JENIS DAN KANDUNGAN LOGAM PADA BATUAN BUANGAN DARI PERTAMBANGAN EMAS POBOYA
Authors: Rahayu Rika , Abram Paulus Hengky
Published: March 2022

Metals has an important role for human life, especially in the industrial field. The purpose of this research is to find out the metal type and content in waste rock from the Poboya gold mine. The sampling technique is done by grabbing sampling, which is to take a lump of rock at a mining site. The analytical method used to determine the content and percentage of elements in rocks is XRF (X-Ray Fluorescence) spectrophotometry. The analysis results show that the metals contained in the waste rock from Poboya gold mining are Silicon (Si), Iron (Fe), Potassium (K), Aluminium (Al), Calcium (Ca), Titanium (Ti), Arsenic (As), Zirconium (Zr), Manganese (Mn), Strontium (Sr), Barium (Ba), Rubidium (Rb), Zinc (Zn), Niobium (Nb), Indium (In), Tin (Sn) and Stibium/Antimony (Sb). The highest percentage metals are Silicon 52.98% and Iron 23.56%. Based on these results, the high content of silica oxide and iron oxide in waste rock from Poboya has the potential as a basis to be used for making nano materials, especially nano silica and ferromagnetic materials.