bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of computationally-guided workflow for designing therapeutic phage cocktail: targeting multidrug-resistant (MDR) bacteria
Authors: Nawaz Rabia , Husnain Ali , Ali Muhammad , Sajjad Moin , Ahad Ammara , Shahid Muhammad , Mehmood Uqba , Abrar Samyyia , Khan Idrees
Published: June 2023

Background:
Antibiotic misuse and overuse have contributed to the emergence of multi-drug resistant bacteria (MDR), a serious public health problem across the globe. Phage cocktails, which combine several phages to destroy various bacterial strains, offer a more thorough and efficient method of battling MDR illnesses. This might revolutionize the looming threat of reemergence of untreatable bacterial diseases. To provide a focused strategy to tackle the rising incidence of MDR bacterial infections, a phage cocktail against Acinetobacter baumannii, Klebsiella pneumoniae, and Pseudomonas aeruginosa was intended to be made computationally. Predicting a group of prophages which can successfully lyse and disrupt these three MDR bacterial strains and might help to lessen the severity and occurrence of illnesses caused by these notorious pathogens.
Methods:
The genomes of selected MDR bacteria were accessed through NCBI GenBank, and prophages targeting them were selected. The prophages were further annotated for ORFs, putative promotors, virulence factors, transcriptional terminators, and tRNAs. Dot plot was created to investigate the similar phages and phylogenetic analysis was performed.
Results:
A total of 11 prophages were predicted from three MDR bacterial genomes, the investigation identified 472 ORFs and CDS, rRNA, and tRNA regions in 11 prophage genomes were predicted. The presence of 3 tRNAs encoded by the predicted prophages suggests a possible reliance on the host translation machinery for protein synthesis. The presence of transcription terminators and promotors were detected to understand the transcriptional and translational regulation of prophage genes. The comparative genomic and phylogenetic analyses of predicted prophages provided important insights into diversity and relatedness of the phages. The final selected five prophages included Acinetobacter baumannii prophage (2759376-2809756), Acinetobacter baumannii prophage (3311844-3364667), Klebsiella pneumoniae (1288317-1338719), Klebsiella pneumoniae prophage (1778306-1808606), and Klebsiella pneumoniae prophage (2280703-2325555).
Conclusion:
In conclusion, our work provides an example of developing a phage cocktail to combat multidrug resistant Acinetobacter baumannii and Klebsiella pneumoniae. Sequence similarity analyses revealed that the cocktail is capable of targeting Enterobacter hormaechei and other carbapenemase-producing K. pneumoniae strains also. The phage cocktail indicates the possibility of being employed as a therapeutic agent for reducing harmful bacterial infections, where conventional antibiotic therapeutics fail.
Prediction of Cadmium Content Using Machine Learning Methods
Authors: Keçeci Mehmet , Gökmen fatih , Usul Mustafa , Koca Celal , Uygur veli
Published: June 2023

Heavy metals are the most environmentally hazardous pollution type in agricultural soils, threatening human and ecological health. Cadmium (Cd) is a highly toxic element but distinctively different with its high mobility in soil environments. The study aimed to evaluate the Cd concentration of Konya plain soils with a specific attribute to soil fertilization practices, mainly phosphorous fertilizers. A total of 538 surface (0-20 cm) soil samples were analysed for the routine soil properties and total phosphorus (P) and Cd. Descriptive statistics, machine learning and regression models considered the accumulation of Cd in soils. Among the MARS, Decision Trees, Linear Regression, Random Forest, and XGBoost machine learning methods used in Cd prediction, the XGBoost model proved to be the best prediction model with a coefficient of determination of 98.1%. EC, pH, CaCO3, silt, and P2O5, which are the soil components used in Cd estimation of XGBoost model, explained 56.51% of the total variance in relation to measured soil properties. Therefore machine learning processes could be a useful tool to estimate the nature of an element in the soils of a specific region by using routine soil properties.
Combined Neurosurgical and Endovascular Management of Complicated Skull Base Cerebral Aneurysms In Emergency Center
Authors: Radanović Dražen , Kaluđerović Dea , Peić Kristina , Stojiljković Aleksandra , Savić Andrija , Matić Sniša , Kolašinac Enes , Pajić Srbislav , Jakovljević Sofija , Elboursh Dušan , Bogosavljević Đurđina , Čukić Bojan , Mirčić Uroš
Published: June 2023

Introduction: Intracranial aneurysms are the main caus of subarachnoid haemorrhage. Most patients with ruptured aneurysms are between 30 and 60 years of age, and the mortality rate is about 50% in the first month after the rupture. Diagnosis and treatment of multiple brain aneurysms still vary from institutions, physicians and individual patients, lacking a defined course of differential diagnosis, risk of rupture and rebleed evaluation and treatment. For multiple intracranial aneurysms, there are currently no unanimous and infallible guidelines for assessing the risk of rupture, recurrent bleeding, or harmonized treatment methods.
Aim: To show the prevalence of multiple aneurysms in the population presenting to the Emergency Center and potentially indicate the right modality of treatment.
Material and methods: The study included 304 patients who were treated for neuroradiologically verified cerebrovascular aneurysms in the Emergency Center of the University Clinical Center of Serbia, Belgrade.
Results: Out of a total of 304 patients diagnosed with intracranial aneurysms, 85 (27,97%) patients were diagnosed with multiple intracranial aneurysms, 85,9% female, 14,1% male. Two aneurysms were recorded in 52 patients (61,2%), 18 patients (21,2%) had 3 aneurysms, 9 patients (10,9%) had 4 aneurysms, and 6 patients (7,06%) were diagnosed with 5 or more aneurysms.
Conslusion: Multiple intracranial aneurysms in our study were present predominantly amongst women. The most frequent localization is ACI followed by ACM, ACoA, AB, while the other arteries were represented in to a very small number of respondents. Endovascular treatment methods are the most prevalent.
Uneven shapes formation mechanism of heavy plate during vertical rolling
Authors: RUAN Jinhua , XIANG Boyang , GUO Wanfu , ZHANG Lisheng , LONG Ding , WANG Zhigang , WANG Yanan , MENG Qingda
Published: June 2023

This paper clarified the formation mechanism of the uneven shapes of a wide and heavy plate during vertical rolling (edging). Coordinate movements of material from the plate length center were constrained by both the rolled part and the to-be-rolled part during the steady edging phase. Then the higher dog-bone height and the shorter dog-bone length were formed around plate length center part, comparing to dog-bone shapes formed at plate head and plate tail. During the plate head edging phase, the main plastic deformation zone extended from the roller-plate contact zone to the plate head. Only the to-be-rolled part constrained deformation of material from the main plastic deformation zone, so it was easier for material flew into its width direction as well as its length direction than it did during the steady edging phase. Coordinate movements of the rolled material led to the width shortage around the plate head zone and increased the plate head concave shape. During the plate tail edging phase, the main plastic deformation zone extended from the roller-plate contact zone to the plate tail. Deformation constrain from the to-be rolled part disappeared gradually while that from the rolled part worked through the plate tail edging. Material of the main deformation zone flew into its width direction as well as its length direction more easily than it did during the steady edging too. Coordinate movements of the to-be rolled material increased the plate tail concave shape. The research results provided deep understanding for SSC in plate/strip edging and guidelines to develop new methods for plate/strip plan view pattern control.
Evaluation on electrochemical properties of lithium ions battery-based PMMA-PLA blend incorporation of [EDIMP]TFSI hybrid gel polymer electrolyte
Authors: Mazuki N. F. , Kufian M. Z. , Samsudin A. S.
Published: June 2023

This study focuses on developing a novel hybrid gel polymer electrolyte (HGPEs) for lithium-ion batteries. The HGPEs are composed of a hybrid polymer of 80 wt.% PMMA and 20 wt.% PLA, doped with 20 wt.% LiTFSI and incorporated with various contents ionic liquid namely Ethyl-dimethyl-propylammonium bis(trifluoromethylsulfonyl)imide ([EDIMP]TFSI) are successfully prepared and the lithium-ion batteries performance were investigated. This work aims to investigate the influence of the ionic liquid on the electrical properties, cation transference number (tLi+), electrochemical stability window, and charge-discharge performance of the PMMA-PLA-LiTFSI HGPE system. Among the different samples tested, the HGPE containing 20 wt.% [EDIMP]TFSI (E-TFSI 20) exhibited the most promising results. It achieved an optimum ionic conductivity of 3.90 × 10− 3S cm− 1, an increasedtLi+from 0.63 to 0.79, and an extended electrochemical stability window from 4.3V to 5V. Temperature dependence studies revealed that all the HGPE systems followed the Arrhenius characteristic, and their activation energies were calculated. Dielectric studies revealed ionic behavior and suitable capacitance with varying frequencies of the HGPEs system. The most favorable electrolyte was selected based on the highest ionic conductivity observed in each HGPE system. It was utilized in a Li metalǀHGPEsǀGraphite cell configuration. The discharge capacity of the cells using LiTFSI 20 and E-TFSI 20 electrolytes were measured as 152.06 mAh g− 1and 71.15 mAh g− 1, respectively, at a current density of 3.72 A g− 1.
Flipped Classroom with Gamified Technology and Paper-based Method for Teaching Vocabulary
Authors: Pratiwi Damar Isti , Fitriati Sri Wuli , Yuliasri Issy , Waluyo Budi
Published: June 2023

A sequential explanatory research design was used to examine the effectiveness of flipped classroom with gamified technology and paper-based method in teaching vocabulary to students with different proficiency levels. Quantitative data was gathered from a pretest and a posttest, whilst qualitative data was collected through teachers’ guided reflection. Using Academic Word List (300 target words), control groups employed a paper-based, while experimental groups applied gamified technology (Quizlet, Kahoot!, Quizizz, Socrative, and Google Form), which lasted 10 weeks. The participants were 144 non-English major students who took a general English course in the 2nd semester of 2023. Quantitative data analysis ran in SPSS 25 using Paired Sample t-Test and One-way ANOVA. The qualitative data were analyzed using thematic progression. The results showed that gamified technology did not affect students’ learning outcomes, while the paper-based method resulted conversely. It revealed that the paper-based method is more effective than gamified technology for students in general, with low proficiency and high-proficiency level. Further, teachers’ beliefs admitted distinctive issues that gamified technology was more effective for high-proficiency learners, whereas paper-based was more effective for low-proficiency learners. The difference analysis of quantitative and qualitative data sheds light on discussing threats while implementing gamified technology and possible solutions.
The Brazil Nut Journey Under Future Climate Change in Amazon
Authors: Anjos Luciano J S , Gonçalves Gabriela S R , Dutra Vitor A B , Rosa Amanda G , Santos Lucyana B , Barros Márcia N R , Souza Everaldo B , Toledo Peter M
Published: June 2023

Climate change poses a significant threat to global terrestrial biodiversity, particularly in megadiverse ecosystems like the Amazon rainforest. This study focuses on the potential impact of climate change on a prominent forest species, Bertholletia excelsa (Brazil nut), which holds multiple dimensions of value in the Amazonian context. By employing an ensemble of distribution modeling methods, we examine four distinct climate scenarios projected for the end of the century. Our research incorporates explicit consideration of dispersal events to simulate the species' spatial dynamics. This approach enables us to predict attributes such as extinction, persistence, and colonization of Bertholletia in future timeframes, spaces, and climatic conditions. Our findings show that, regardless of the evaluated climate scenario, B. excelsa would experience a widespread loss of suitability by the end of the century, resulting in a substantial reduction (up to 94%) of area for the specie. Moreover, our results suggest that the specie would seek more favorable conditions by colonizing higher altitudes in the future. Encouragingly, we identify areas that may regain suitability by the end of the century, which could inform active restoration efforts to mitigate the detrimental effects of climate change on the specie.
Leaking Secrets in Homomorphic Encryption with Side-Channel Attacks
Authors: Aydin Furkan , Aysu Aydin
Published: June 2023

Homomorphic encryption (HE) allows computing encrypted data in the ciphertext domain without knowing the encryption key. It is possible, however, to break fully homomorphic encryption (FHE) algorithms by using side channels. This article demonstrates side-channel leakages of the Microsoft SEAL HE library. The proposed attack can steal encryption keys during the key generation phase by abusing the leakage of ternary value assignments that occurs during the number theoretic transform (NTT) algorithm. We propose two attacks, one for -O0 flag non-optimized code implementation which targets addition and subtraction operations, and one for -O3 flag compiler optimization which targets guard and mul root operations. In particular, the attacks can steal the secret key coefficients from a single power/electromagnetic measurement trace of SEAL’s NTT implementation. To achieve high accuracy with a single-trace, we develop novel machine-learning side-channel profilers. On an ARM Cortex-M4F processor, our attacks are able to extract secret key coefficients with an accuracy of 98.3% when compiler optimization is disabled, and 98.6% when compiler optimization is enabled. We finally demonstrate that our attack can evade an application of the random delay insertion defense.
Displaying quasi-brittle failure using avalanches: paper as a material model
Authors: VILLETTE François , BAROTH Julien , DUFOUR Frédéric , DU ROSCOAT Sabine ROLLAND
Published: June 2023

This article aims to discuss and complete the avalanche representations of the failure process of quasi-brittle materials. Paper was used as a model material. We proposed an original method to determine avalanches extracted directly from the force drops in the post-peak regime of experimental force-displacement curves. We studied the avalanche distributions on notched and unnotched samples, taking into account the measurement noise. From these experimental tests, a two regimes power-law in the avalanche distribution was observed during the propagation of a macrocrack, that was consistent with other avalanche distributions based on other methods and other materials in literature. A single power-law was found for a diffuse damage (without a significant macrocrack propagation) using the Mazars’ damage model. Our results showed that the post-peak regime of tensile curves contained the statistical signature of the propagation of a macrocrack during the rupture of paper.
The Usage of Internet in the Context of ESG Model at World Level
Authors: Leogrande Angelo
Published: June 2023

In this article, I estimate the value of “Individual Using Internet”-IUI in the context of Environmental, Social and Governance-ESG database of the World Bank. I use data from 193 countries for the period 2011-2020. I found that among others the value of IUI is positively associated to “Methane Emissions” and “People Using Safely Managed Sanitation Services” and negatively associated among others to “Fossil Fuel Energy Consumption” and “Renewable Energy Consumption”. I apply the k-Means algorithm for the clusterization optimized with the Elbow Method and we find the presence of three clusters. Finally, I confront eight machine-learning algorithms to predict the future value of IUI. I found that the best predictive algorithm is Linear Regression and that the value of IUI is expected to decrease on average of 0.30% for the analysed countries.
JEL Classification: D7, D70, D72, D73, D78.
Modifying lignin composition and xylan O-acetylation induces changes in cell wall composition, extractability, and digestibility.
Authors: Chaudhari Aniket Anant , Rastogi Lavi , Dewangan Bhagwat Prasad , Sharma Anant Mohan , Sharma Raunak , Singh Deepika Manju , Sah Rajan Kumar , Das Shouvik , Bhattacharjee Saikat , Mellerowicz Ewa J , Pawar Prashant Anupama-Mohan
Published: June 2023

Background
Lignin and xylan are important determinants of a cell wall structure and lignocellulosic biomass digestibility. Genetic manipulations that individually modify either lignin or xylan structure improve polysaccharide digestibility. However, the effects of their simultaneous modifications have not been explored in a similar context. Here, we generated combinatorial cell wall mutants and studied the consequences on plant cell wall properties, biotic stress responses and plant cell wall integrity.
Results
Arabidopsis plant co-harbouring mutation in ferulate 5-hydroxylase (fah1-2) and overexpressing Aspergillus niger acetyl xylan esterase (35S:AnAXE1) transgenic were generated and displayed normal growth attributes with intact xylem architecture. This fah1-2/35S:AnAXE1 crossed named as hyper G lignin and hypoacetylated (HrGHypAc) line. The HrGHypAc plants showed increased crystalline cellulose content with enhanced digestibility after chemical and enzymatic pre-treatment. Moreover, both parents and HrGHypAc without and after pre-treating with glucuronyl esterase and alpha glucuronidase exhibited an increase in xylose release after xylanase digestion as compared to wild-type. The de-pectinated fraction in HrGHypAc displayed elevated levels of xylan and cellulose content. Furthermore, the transcriptomic analysis revealed differential expression in cell wall biosynthetic, transcription factors and wall-associated kinases genes implying the role of lignin and xylan modification on cellular processes.
Conclusions
Simultaneous modification in xylan and lignin improve cellulose content with enhanced saccharification efficiency. These modifications loosen cell wall complexity and hence resulted in enhanced xylose release with or without treatment after xylanase digestion. This study also revealed that the disruption of xylan and lignin structure is possible without compromising either growth and development or defense responses against Pseudomonas syringae infection.
Insights on Multi-Spectral Vegetation Indices Derived From Uav-Based High-Throughput Phenotyping for Indirect Selection in Tropical Wheat Breeding
Authors: Silva Caique Machado e , Mezzomo Henrique Caletti , Ribeiro João Paulo Oliveira , Signorini Victor Silva , Lima Gabriel Wolter , Vieira Eduardo Filipe Torres , Portes Marcelo Fagundes , Morota Gota , Corredo Lucas de Paula , Nardino Maicon
Published: June 2023

High-throughput phenotyping (HTP) approaches are potentially useful for the accurate and efficient evaluation and selection of superior genotypes, leveraging high genetic gains. Vegetation indices are of particular interest because they allow indirect selection. Considering the lack of information regarding high-throughput phenotyping approaches in tropical wheat breeding, this study aimed to (i) determine the best stages to carry out image acquisition for applying multi-spectral vegetation indices; (ii) evaluate the heritability and accuracy of multi-spectral vegetation indices; (iii) understand the relationships between vegetation indices and target agronomic traits; and (iv) evaluate the efficiency of indirect selection via UAV-based high-throughput phenotyping. A diversity panel of 49 tropical wheat cultivars was evaluated during the 2022 winter season. Weekly flight campaigns were performed to further build multi-spectral vegetation indices, which were then analyzed together with four target agronomic traits. Mixed model analyses were performed to estimate genetic parameters and predict genetic values, which were subjected to correlation analysis. Additionally, factor analysis was applied, and the factorial scores were used in an indirect selection strategy (indirect via HTP). This strategy was compared to three alternative strategies: direct via grain yield, direct via days to heading, and the multi-trait genotype-ideotype distance index. The results indicate that vegetation indices are suitable for indirect selection strategies and highly efficient for the indirect selection of grain yield and cycle. The findings of this study will help decision making regarding the use of these approaches in Brazilian public wheat breeding programs.
Temporal trends, sex differences, and age-related disease influence in Neutrophil, Lymphocyte count and Neutrophil to Lymphocyte-ratio. Results from InCHIANTI follow-up study.
Authors: Pellegrino Raffaello , Paganelli Roberto , Iorio Angelo Di , Bandinelli Stefania , Moretti Antimo , Iolascon Giovanni , Sparvieri Eleonora , Tarantino Domiziano , Ferrucci Luigi
Published: June 2023

Background
Neutrophils and lymphocytes represent the larger percentage of all blood white cells, they vary with age, with a progressive increase of the ratio in the first years of life, and then tend to remain at similar levels in steady state condition during adult age. Neutrophils to lymphocytes-ratio (NL-ratio) was proposed as an effective and low-cost marker to monitor and predict clinical condition evolution.
The main objective of the study is to analyze its temporal trend variation, over twenty years’ follow-up, according to age, sex, and main clinical diagnosis, in a large representative Italian population.
Methods
The InCHIANTI study enrolled representative samples from the registry list of two towns in Tuscany, Italy. Baseline data were collected in 1998, and last follow-up visits in 2015-18. Out of the 1453 participants enrolled, 1343 were included, and consented to donate a blood sample. All subjects were assessed and followed for life-style, clinical condition, physical performance, and underwent an instrumental diagnostic session.
Results
The NL-ratio showed a statistically significant interaction between birth-cohort and time of the study (p-value=0.005). A gender dimorphism was recognized in the neutrophils absolute count and in the NL-ratio. Moreover, in female participants only, those who reported CHF had lower neutrophil-count and NL-ratio; whereas an increase in creatinine clearance was directly associated with NL-ratio. In male subjects, an increase of BMI was inversely associated with both NL-ratio and neutrophils-count during the follow-up; a similar association but in the opposite direction was observed in female participants.
Conclusion
NL-ratio is a more reliable marker of biological age than absolute lymphocytes and/or neutrophils counts. It is associated with the changes induced by disease, lifestyle, and environmental challenges in the immune system. NL-ratio confirms the gender dimorphism in the occurrence of inflammation-driven diseases. Therefore, additional evidence emerged for the necessity for tailored sex-specific measures to prevent and treat such diseases.
Design of a Conversational Recommender System in Education
Authors: Valtolina Stefano , Matamoros Ricardo Anibal , Battaglia Alberto , Mascari Michelangelo , Epifania Francesco
Published: June 2023

In recent years we have seen a significant proliferation of e-learning platforms. E-learning platforms allow teachers to create digital courses in a more effective and time-saving way, but several flaws hinder their actual success. One main problem is that teachers have difficulties finding and combining open-access learning materials matching their specific needs precisely when there are so many to choose from. This paper proposes a new strategy for creating digital courses that use learning objects (LOs) as primary elements. The idea consists of using an intelligent chatbot to assist teachers in their activities. Defined using RASA technology, the chatbot asks for information about the course the teacher has to create based on her/his profile and needs. It suggests the best LOs and how to combine them according to their prerequisites and outcomes. A chatbot-based recommendation system provides suggestions through BERT, a machine-learning model based on Transformers, to define the semantic similarity between the entered data and the LOs metadata. In addition, the chatbot also suggests how to combine the LOs into a final learning path. Finally, the paper presents some preliminary results about tests carried out by teachers in creating their digital courses.
SINKRONISASI PENGATURAN KEWENANGAN CABANG RUTAN BNN TERHADAP PP NOMOR 58 TAHUN 1999 DALAM KERANGKA SISTEM PEMASYARAKATAN
Authors: Soge Markus Marselinus
Published: June 2023

The responsibility of organizing the correctional system includes the construction of inmates and the treatment of prisoners at        the Directorate General of Corrections, but in practice, prisoners are not always in Rutan or Rutan Branch owned by Kemenkumham. BNN also manages Rutan Branch which is regulated in BNN Head Regulation No. 6 of 2016 concerning Prisoner Supervision. The problem here is how the synchronization level of the regulation of the authority of Rutan Branch of BNN against PP No.58 of 1999 within the framework of the correctional system. Normative legal research methods with legal approaches are used in this paper, and also used secondary data, namely primary and secondary legal materials. The data is collected by library study techniques, then qualitatively analyzed with legal interpretation. The results of the study are using guidelines for evaluation of legislation, especially table 3 assessment with variable 'authority' then the BNN Head Regulation No. 6 of 2016 is unsynchronized with PP No.58 of 1999 in the indicator 'there are arrangements about the same authority on 2 (two) or more regulations whose hierarchy is different, but the implementing agencies are different'. It is recommended that the Directorate General of Corrections of Kemenkumham can coordinate with BNN to discuss the unsynchronized of the authority arrangements of the Rutan Branch of BNN related to the supervision of prisoners to strengthen the implementation of the correctional system.
A bibliometric analysis of the publications by Tamás Pócs
Authors: Podani János
Published: June 2023

This paper provides a statistical evaluation of the publication record of Tamás Pócs, from 1954 to 2022. During this period, he contributed to 550 publications of which 232 were authored only by himself. Frequency histograms are used to demonstrate the distribution of the number of his articles, books and book chapters for six variables: topic, document type, number of authors, year of appearance, geographical scope and language. It is remarkable that his publication activity was the highest in the past 20 years. Principal components analysis is used to reveal the correlation structure between ten features characterizing the publications.
RECURRENTHEMATOCOLPOS DUE TO ISOLATEDATRESIA OF THE LOWERTHIRD OF THE VAGINA: A CASE REPPORT
Authors:   Department of Obstetrics & Gynecology, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., Hamid Asmouki , Mohamed Hicham Abdelkhalki ,   Department of Obstetrics & Gynecology, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., Karim Lakraimi ,   Department of Obstetrics & Gynecology, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., Lahcen Boukhani ,   Department of Obstetrics & Gynecology, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco., Abderraouf Soummani ,   Department of Obstetrics & Gynecology, Faculty of Medicine and Pharmacy, Cadi Ayyad University, Marrakech, Morocco.
Published: June 2023

Reccurent hematocolpos is a rare condition that can be due to many malformations . One of them is the atresia of the lower third of vagina, wich is due to an anomaly in the development of the terminal part of the MÃ¼llerâ€™s canals. Case: We report the clinical case of a 15-year-old patient who presented primary amenorrhea associated with cyclic pelvic pain, in whom speculum examination revealed a blind vagina. The after finds the notion of hematocolpos cure with recurrence on 2 occasions. MRI revealed isolated atresia of the lower third of the vagina. The diagnosis of aplasia of the lower third of the vagina on a functional uterus was retained. The patient had a vaginal plasty by vaginal route. The evolution was good with regular cycles and improvement of pelvic pain. The follow-up is one year. Conclusion: Regardless of the surgical technique used, vaginoplasty allows in this rare condition to restore good life quality and prevent endometriosis.
LITERATURE REVIEW OF PRAKRITI AND ITS PHYSIOLOGICAL FACTORS AND BEHAVIOURALFACTORS
Authors: Soni Shilpa , a Gitanjalisasmal , Bhardwaj Vinay
Published: June 2023

In Ayurveda, this genetic charter of an person, which stays constant at some stage in the existence is known as prakriti, Ayurveda point out numerous houses of tridosha (body humors) and the way they affect prakriti or humans body structure, primarily based on the dominance of one or extra doshas. an amazing understanding of prakriti is critical for the development of template for individualized diet, life-style counseling, and remedy. inside the present descriptive literary assessment, a widespread device developed for prakriti evaluation primarily based on considering numerous elements of the body constitutions. The phrase Prakriti method Nature or in construct phenomena of human frame. Prakriti of humans based totally on vital part i.e genetic in addition to outside elements. Genetic elements depend on Shukra and shonita Prakriti is not output of these dosha, which go through constant variations. Dosha which stays constant from birth till dying are chargeable for Prakriti. once fashioned Prakriti is also prompted though not modified due to environmental elements.
STUDY OF DRAINAGE SYSTEM AND ITS HYDROLOGICAL IMPLICATIONS USING GEO-SPATIAL TECHNIQUES: A MORPHOMETRIC ANALYSIS IN MUTHUGAD WATERSHED OF GRAHWAL HIMALYA, UTTARAKHAND
Authors:   Department of Geography SSJ University Almora, Uttarakhand (India)., Arya Manju , a Deepak ,   Department of Geography SSJ University Almora, Uttarakhand (India)., Rawat J. S. ,   Department of Geography SSJ University Almora, Uttarakhand (India).
Published: June 2023

Measurements of the shape or geometry of any natural form, including those of plants, animals, and relief features, are referred to as morphometry. Morphometry is the accurate measurement of landforms. One of the crucial requirements for effective management and planning of water resources within the watershed is an understanding of the behavior of the surface drainage network. In order to comprehend and interpret the dynamics of the watersheds drainage system and to understand the drainage network features, morphometric study of a watershed is a vital stage in watershed development and management. Watershed characterization includes morphometry as a key component. Aspects that are dimensional, aerial, and relief are typically present for the conservation of surface and ground water, watershed development and management strategies are crucial. Applying mathematical equations and statical measures to data from topographic maps and satellite images, morphometric attributes reflect a measurement of the earths surface and are processed in accordance with the principles of quantitative analysis. A study of drainage morphometry and its impact on the hydrology of the Mathugad watershed, Grahwal Himalaya, Uttarakhand (India) has been made. Total basin covers 77.12 sq km area. Shuttle Radar Topographic Mission (SRTM) data and on 1:50000 scale and Survey of India Toposheet as reference were utilized to create slope maps, aspect grids, and digital elevation models (DEMs) for the thorough investigation. Geographic information systems (GIS) were employed to assess the linear, areal, and relief aspects of the morphometric parameters. Numerous morphometric features of the Mathugad watershed have been intended by applying GIS techniques and using SRTM data. The research shows that the rainfall has a moderate to large impact on how stream segments develop in the basin area thrusting and faultings controlling influence is primarily responsible for the basins elongated structure. Relief ratio indicates that the discharge capability of these watersheds is very high and the groundwater potential is meager. Dendritic drainage pattern in the area shows that the area consists of homogeneous rock material which is structurally undisturbed. Form factor and circulatory ratio statics indicates basin shape is elongated the results clearly indicate relations among various morphometric attributes of the basin and help to understand their role in sculpturing the surface of the region. These studies are very useful for planning rainwater harvesting and watershed management.
COMPARING THE EFFICACY OF MODIFIED CONTINUOUSSMEAD-JONES VERSUS CONVENTIONAL CLOSURE OFMIDLINE LAPAROTOMYWOUND
Authors:   Associate Professor, Department of General Surgery, Mysore Medical College and Research Institute., M.N Raghuveer , Kumar R. Chandan ,   General Surgery Postgraduate,Mysore Medical College and Research Institute., Hubballi Vishal ,   General Surgery Postgraduate, Mysore Medical College and Research Institute.
Published: June 2023

Background: Disruption of abdominal incision is a serious event. Variousmethods have been employed in abdominal surgeries to close theabdominal wall.Abdominal wound dehiscence is a common complication of emergency laparotomy. Thereis an increase in the cost and hospitalstays. Prevention of this complication is important inreducingpost-operativemorbidity and mortality. Objectives: ThestudywascarriedoutintheDepartmentofGeneralSurgery,MMC&RI,Mysuru. 1. ToevaluateeffectivenessofmodifiedcontinuousSmead-JonesTechnique. 2. To compare effectiveness of modified continuous Smead-Jones withconventionaltechniqueofabdomenwoundclosureonthebasisofincidenceofwounddehiscence. Methods: The study was carried out on a total of 110 patients who were randomized intwo groups of 55 each. 55 patients underwent closure of mid line laparotomywound using modified continuous Smead-Jones technique(study group)and 55 patients underwent closure by conventionalmethod(control group). Results: The mean age group was 46 to 49. Male patients were more common comparedtofemale.Outofthevariouscausesofacuteabdomen,Prepyloricperforationwasthemostcommoncause,followedbyduodenalperforation.Outof 11 cases who had wound dehiscence,mostofthemwere for Pre pyloric perforation(55%), second most common was ileal perforation(27%). Patientswith risk factors had higher incidence of wound infection and wound dehiscence. Outof 110 patients, 32(29.1%) had wound infection, 12(21.8%) in the study group and20(36.3%) inthecontrolgroup.A total of 11(10%) patients had wound dehiscence, only 2 (3.6%) patients in the studygroup, whereas 9 (16.3%) in thecontrol group. Interpretationandconclusion:ModifiedSmead-Jonestechniquedecreasestheincidenceofwounddehiscenceand can be used to close the midline laparotomy wound in cases requiring emergencymidlinelaparotomy.
CERVICAL VESTIBULAR EVOKED MYOGENIC POTENTIALS IN PATIENTS WITHTYPE IIDIABETES MELLITUS
Authors:   Fellow of Audio Vestibular Medicine at Hearing and Speech Institute., Fadel Hanaa , Mahran Sanaa ,   Fellow of Audio Vestibular Medicine at Hearing and Speech Institute.
Published: June 2023

Introduction:Vestibular impairment has been demonstrated in patients with diabetes mellitus. Vestibular evoked myogenic potential (VEMP) is a short latency electromyographic response to sound or vibration stimuli that may reflect otolith organ or related reflex functions. cVEMPs are summation responses recorded from the contracted sternocleidomastoid inresponse to synchronized acoustic stimulation of the ipsilateral ear/saccule.In diabetic patients. Objective: Here, we asses prevalence of vestibular dysfunction by measuring cVEMP findings in patients with diabetes mellitus typeII. Methods: This study was carried out on two groups of subjects including 20 adult subjects with diabetes mellitustypeIIand 20 adult subjectsnon-diabetics, both group their aged ranged from 20-60 years. Results:showed statistically significant difference in cVEMP between diabetes mellitus type 2 control group with increase in latencies of P1 and N1 and decrease in amplitude. Conclusion: In diabetic individuals who are asymptomatic and never complained of vestibular dysfunction, cVEMPsis able to identify these patients.
EFFECT OF UTILIZING INTERACTIVE VIRTUAL LAB ON STUDENTS PERFORMANCE IN PHYSICS
Authors: Erven H. Mosqueda Clint
Published: June 2023

CLINT ERVEN H. MOSQUEDA. 2023. Effect of Utilizing Interactive Virtual Lab on Students Performance in Physics, MSTP Thesis. Graduate School, University of Southern Mindanao, Kabacan, Cotabato. 80pp.Major Adviser: JEAN R. MAGANAKA, MSTPThis research investigated the effect of utilizing interactive virtual lab (Labster) on students performance in physics among the grade 10 of Dungoan High School. It is a quasi-experimental research that uses the Randomized Pretest-Posttest Control Group Design, Using Matched Subjects. Differences in the performances of students who used Labster (experimental group) and with those who did not utilize it (control group) were tested in terms of the result in the posttest. Students performances were measured using a 40-item test that undergone pilot testing and content validation.Results revealed that the significant increase of students performance in the experimental group provides positive effect as (computed U = 2.000, p < 0.001). It wasfound that the use of Labster contribute on enhancing students learning in physics.Results in the rank gain scores with a significant difference in two groups (computed U = 5.500, p < 0.001) revealed that Labster also developed positive attitude towards learning physics with large Cliffs effect size difference of d = 0.71. Thus, there was a significant difference between the experimental and control group. The qualitative part of this research revealed that students perception in utilization of Labster was a great technological integration in terms of learning contents, interface design, and learning experiences with a weighted mean of 4.08, 4.34, and 4.72 respectively. Moreover, the experimental group experienced difficulties while using Labster such as (1) program incompatibility with lower processor (2) incapability to perform tasks with more than two activities at a time and (3) insufficient computer literacy.
DETERMINANTS OF ADOPTION OF MOBILE GAMES: EXTENDING UTAUT2 WITH TRUST AND REWARD
Authors: ERDOĞAN Görkem
Published: June 2023

This paper's goal is to investigate the variables influencing mobile gaming players' behavior intention based on the unified theory of acceptance and use of technology 2 (UTAUT2) model. The UTAUT2 model is expanded by adding variables, trust, and reward, in addition to the model’s variables. The behavior intention to adopt mobile game is used and usage behavior is taken as the dependent variable. A survey is conducted and a sample of 474 mobile game players in Turkey is analyzed through structural equation modeling approach. The results indicate that reward has the most influential effect on behavior intention, followed by trust, price value, habit, social influence, performance expectancy, facilitating conditions, hedonic motivation, and effort expectancy. Besides, behavior intention has a significant positive effect on the usage behavior. The findings of the research fill the gap in existing literature on mobile games as well as provide valuable base for forthcoming research findings in mobile games.
Risk screening of non-native suckermouth armoured catfishes Pterygoplichthys spp. in the River Dinh (Vietnam) using two related decision-support tools
Authors: Zworykin Dmitry , Đinh Thị Hải Yến
Published: June 2023

The invasion risk of non-native suckermouth catfishes Pterygoplichthys spp. in the River Dinh (Vietnam) was evaluated using two related decision-support tools, namely the Fish Invasiveness Screening Kit (FISK) and the Aquatic Species Invasiveness Screening Kit (AS-ISK). The results of screenings obtained independently by three assessors using both toolkits were evaluated for consistency, and compared with a screening study previously obtained for Vietnam as a wide risk assessment area. Both FISK and AS-ISK based screenings were shown to provide adequate and potentially important outcomes in terms of risk of invasiveness and were consistent amongst assessors and between toolkits. The invasion risk of Pterygoplichthys in the River Ding was found to be high and the traits of these fishes that influence their success of becoming established were considered. Some aspects in the use of FISK and AS-ISK as decision-support tools as part of the overall risk analysis of species’ invasions for large risk assessment areas are discussed.
Comparative study of simple and modified rice husk biochar for cadmium removal: Adsorption performance and possible mechanisms
Authors: Gautam Kaushik , Gupta Neha , Patel Devendra Kumar , Singh Rajeev Pratap , Singh Anita
Published: June 2023

In the present study, the simple and chemically modified forms of biochar (KMnO4 and HNO3; 0.01 M) obtained from rice husks were used to study the possible mechanism behind the process of cadmium (Cd) adsorption from the synthetic solution having Cd2+ ranged from 10 to 50 ppm. At 50 ppm, the maximum adsorption has been observed and it showed 93% removal by the KMnO4 modification and 86% by HNO3 modification, whereas simple biochar led to 82% removal only. The adsorption pattern follows the Langmuir and pseudo-second-order model. With characterization techniques, it has been confirmed that the KMnO4-modified forms of biochar showed more adsorption capacity than HNO3-modified and simple biochar. Furthermore, to check its practical applicability, the modified forms of biochar have been applied to the wastewater collected from Banaras locomotive works, Bhagwanpur, and Lohta sites of Varanasi city, UP, India. Again, the maximum adsorption of Cd2+ has been observed with KMnO4 modification (92–95%) at all the sites. This result also confirmed that KMnO4 was the best modifying agent over HNO3. Therefore, its application could be promoted in metal-contaminated water and soil to decrease the availability of toxic metals.
Data management in life cycle assessment: a case study of wastewater treatment
Authors: Straub Julia , Hofmann Josef , Hehenberger-Risse Diana
Published: June 2023

To assess the environmental impact of wastewater treatment, life cycle assessment (LCA) is a frequently applied instrument. However, these studies often require large amounts of data. The complexity and heterogeneity of these data result in the need for a systematic data management approach. Especially the generation of the life cycle inventory (LCI) holds the potential to be facilitated by automation. A case study in the wastewater sector was used to demonstrate the implementation of data management. A database structure was developed to store the raw data of the wastewater plants (WWTPs) and make it accessible through code. The code interacted with the database, implemented calculations, and automatically created the inventory based on the processed data. The database provides a consistent structure for the raw data and can also be used for backup purposes. Because it is machine-readable it can be accessed through the code that enables the automated generation of the LCI. As a proof of concept, a sequence of the code is provided with a user interface and can be tested online. We found that for most use cases, basic programming tools were sufficient for systematic data management, and, therefore, the approach is considered accessible for LCA practitioners.
Abundance, characteristics, and removal of microplastics in the Cihu Lake-wetland microcosm system
Authors: Li Yuxiao , He Jiaqing , Li Yixin , Sun Zhiquan , Du Hao , Wang Dongliang , Zhang Peng , Li Haixiao
Published: June 2023

Sewage treatment plants (STPs) are significant routes through which microplastics (MPs) are released into the aquatic environment. Constructed wetland is an effective facility for deep treatment of tailwater. At present, research on the removal of MPs in the tailwater of STPs by multi-stage constructed wetlands is limited. This work investigated and analyzed the removal characteristics of MPs in the tailwater treatment system of Cihu wetland park in Huangshi, Hubei Province of China. The abundance/removal of MPs in the Cihu Lake-wetland microcosm system was investigated. The results showed that the multi-stage constructed wetlands achieved a total removal rate of 94.7% for MPs with 2.2 particles/L MPs in the effluent. The removal rates of MPs reached 89 and 37.5%, respectively, in the (horizontal/vertical) subsurface flow constructed wetland and surface flow constructed wetland. The abundance of MPs in receiving water of Cihu Lake substantially decreased due to the dilution of wetland effluents. This study partially bridged the knowledge gap hypothesis on the treatment of MPs in tailwater by multi-stage constructed wetlands.
Urbanización y medio ambiente: las reservas naturales urbanas en San Carlos de Bariloche
Authors: Guevara Tomás , Wallace Julieta , Arribas Julián
Published: June 2023

Las ciudades intermedias tienen un protagonismo destacado en el crecimiento urbano de las últimas décadas. Las tensiones entre urbanización y ambiente son relevantes para entender la emergencia de conflictos socioambientales en dichas ciudades. El objetivo de este trabajo es analizar el conflicto socioambiental de larga duración y baja intensidad relacionado con la presión que ejerce la mancha urbana sobre el área de bosques en San Carlos de Bariloche, Argentina. La hipótesis que guía la investigación es que el crecimiento urbano de la ciudad de San Carlos de Bariloche está modulado por la dinámica de la problemática mencionada. La investigación desarrolla un estudio de caso instrumental para realizar una contribución a cómo se estructuran los conflictos socioambientales en ciudades intermedias y cómo se desarrollan respuestas institucionales a estos. El artículo aporta a la comprensión de la interacción entre movimientos ambientales de base territorial y la implementación de políticas urbanas en ciudades intermedias.
Cronología y contextos funerarios prehispánicos Capulí en El Porvenir, municipio de Iles, departamento de Nariño, Colombia
Authors: Mendoza Acosta Ricardo , Henry Marín Katina
Published: June 2023

La información arqueológica que se presenta en este documento hace parte de los resultados del Programa de Arqueología Preventiva que se llevó a cabo en el marco de la ejecución del Proyecto Vial Rumichaca-Pasto. La investigación se basa en la excavación de 47 contextos funerarios inalterados que se hallaron en la vereda El Porvenir, municipio de Iles, (Nariño, sur de Colombia). El cementerio se fechó sobre los siglos IV y V d. C., lo que permite aproximarse al entendimiento de los procesos de ocupación y el modo de vida social y simbólico de los grupos prehispánicos que se asentaron en la región. Se hallaron evidencias en la tipología cerámica y las fechas que relacionan El Porvenir con los grupos humanos prehispánicos que se asentaron en el norte de Ecuador, lo que visibiliza un gran uso de este territorio que, en términos políticos, es importante. Así mismo, los hallazgos de esta importante cantidad de contextos funerarios reafirman el reconocimiento y legitimación social y simbólica del territorio. En términos de sitios de enterramientos, estos contextos se diferencian de otros de su misma temporalidad y cultura, debido a la gran variabilidad encontrada entre las estructuras.