bluuebunny/crossref_metadata_2025 huggingface dataset:
Nitrate removal in potable groundwater by nano zerovalent iron under oxic conditions
Authors: Kodikara Jayanga , Gunawardana Buddhika , Jayaweera Mahesh , Sudasinghe Madhusha , Manatunge Jagath
Published: October 2020

Groundwater pollution by nitrate contamination has become a significant issue in some areas of Sri Lanka, giving rise to health concerns and a dearth in good quality potable water. In this study, the effectiveness of nano zerovalent iron (nZVI) for the removal of nitrate in potable groundwater under oxic conditions was investigated to meet the drinking water quality standards stipulated by World Health Organization (WHO) and Sri Lanka Standards Institution (SLSI) (nitrate level <50 mg/L). Under oxic conditions, the nZVI was synthesized and batch experiments were conducted using an artificial nitrate (150 mg/L) contaminated water sample. Our results corroborated that with an optimum nZVI dose of 1 g/L and optimum contact time of 30 minutes, 80% nitrate removal could be achieved and the remaining nitrate level was ≈ 30 mg/L as nitrate (<50 mg/L), which was equivalent to ≈ 7 mg/L as nitrate–N (≈21% of the total–N). Ammonium ions were the main product of nitrate reduction by nZVI and at 30 minutes contact time, ≈ 20 mg/L of ammonium as ammonium–N was detected (≈ 59% of the total–N). Ammonia stripping took place under the basic solution pH (pH > 9.5). At 30 minutes of contact time, ≈7 mg/L of ammonia as ammonia–N was accounted for ammonia stripping, which is 20% of the total–N. Ammonia stripping resulted in a decrease in nitrogen-containing species in the aqueous phase. The spent nZVI particles were recovered (99.9%) from the treated water using an external magnetic field. In conclusion, nZVI particles synthesized under oxic conditions are viable to successfully treat the nitrate-contaminated groundwater under aerobic conditions to reduce the nitrate levels to meet the WHO/SLSI drinking water quality standards.
Variables que inciden en el trastorno de síntomas somáticos: un modelo de regresión logística
Authors: Bernáldez-Jaimes Germán Benito , Oudhof-van-Barneveld Johannes , Robles-Estrada Erika , Domínguez-Espinosa Alejandra del Carmen
Published: October 2020

El Trastorno de Síntomas Somáticos (TSS) se refiere a la presencia de malestares de carácter físico acompañados de preocupaciones y conductas excesivas relacionados a la salud, cuya etiología es considerada multifactorial, entre los cuales se encuentran el estrés, características personales, exposición a situaciones traumáticas y creencias irracionales. Es por ello que la presente investigación tuvo por objeto desarrollar un modelo de regresión logística con el fin de analizar la incidencia de dichos factores sobre el TSS. Se trabajó con una muestra de 201 participantes divididos en dos grupos, 111 con diagnóstico de TSS y 90 no clínicos. Se realizó un análisis de regresión logística binaria donde la prueba de Omnibus (Chi cuadrada de 84,982, p<0,001) indica que las variables del modelo contribuyen a explicar el fenómeno. La prueba Hosmer-Lemeshow (Chi cuadrada de 8,603, p=0,377) mostró su ajuste a la realidad, con cuatro variables de riesgo; siendo las Quejas Gastrointestinales la de mayor proporción con un Coeficiente de Regresión de 1,053, seguida de la Preocupación y Estrés, Introversión y Pensamientos Automáticos Negativos; mientras que la Indefensión y Desesperanza disminuyen la probabilidad del TSS. Las quejas recurrentes de carácter gastrointestinal parecen ser los factores predictores más comunes del TSS.
Intervención comunitaria para el cuidado de la salud en la comuna 7 de Santa Marta, Colombia
Authors: Campo-Torregrosa Yelis , Toncel-Mutis Yasmina , Olaya-López Catalina , Padilla-Constante Kisi
Published: October 2020

Los problemas sociales son considerados, una condición que afecta a un número significativamente de personas, los cuales deben ser corregidos mediante acciones colectivas, teniendo en cuenta que el barrio seleccionado para este proyecto que alberga una gran población desplazada por la violencia lo que hace que haya un incremento en el analfabetismo, pobreza, drogadicción, desnutrición, hacinamiento, violencia intrafamiliar, problemas de salud en general, situación que impide el desarrollo o el progreso de una comunidad o de uno de sus sectores. La Universidad Cooperativa de Colombia a través del Programa de Enfermería, realizó el diagnóstico de salud con énfasis en salud familiar a partir de la aplicación del censo poblacional, lo que nos sirvió como insumo para los indicadores de salud y posterior intervención en la comunidad y de esta manera, asegurando la existencia y continuidad del proyecto e inserción de la comunidad. El proyecto involucro además de la Universidad otras organizaciones cívicas, educativas y sociales del sector. Por tal razón se concibe como una experiencia participativa de la comunidad, en el cual se impartirán conocimientos éticos y morales para contribuir así con el desarrollo integral del ser mismo y por ende de la comunidad de Santa Marta.
Autologous transplant third mandibular molar in post extraction socket. Case report
Authors: Tovío-Martinez Eilien , Urbano Del Valle Samuel , Gamarra-García Jhonatan
Published: October 2020

Dental transplantation is a surgical alternative, which consists of transplanting a tooth from one alveolus to another in the same patient, very useful when replacing lost dental organs in young patients, with a high success rate. Present advantages helpful for patients providing a vital, proprioceptive and excellent aesthetic rehabilitation, without altering adjacent teeth, additionally represents an alternative cheaper. The purpose of this case report is to show clinical sequence about surgical approach for dental autotransplantation from lower third molar on alveolus after extraction of right lower first molar, carried out without endodontic treatment. Female patient case of 15 years old with a diagnosis of extensive caries not restorable in 46 is presented. It is decided through an interdisciplinary board to carry out, treatment with an autologous transplant of right lower third molar in socket post-extraction of first lower molar from the same hemiarchate, post-surgical controls are performed for up to one year. Dental transplantation is an excellent treatment option when it comes to replacing missing teeth, since it offers multiple functional and aesthetic advantages, mainly in children and young adults.
Solución con calidad y reducción de tiempo clínico en prótesis bucal. Reporte de un caso
Authors: Rodríguez-Hernández Jorge Alberto , Soto-Cos Leyden , Pol-Rodríguez Estela , Hernández-Sánchez Carmen María , Pérez-Álvarez Mayra de la C. , Pérez-Fuentes Maydel
Published: October 2020

Los pacientes que precisan rehabilitaciones extensas, en ocasiones, se les dificulta el tratamiento por el tiempo y visitas repetidas a la institución de salud. Reportamos un caso clínico con estas características, que presentaba, en todos los dientes remanentes considerable pérdida ósea por lesiones periodontales graves y caries dental, necesitado de extracciones dentarias múltiples en cirugía bucal y rápida rehabilitación protésica total de forma inmediata, pues disponía limitado tiempo para tratarse. Al paciente no era posible rehabilitar con implantes dentarios bajo estas condiciones. Para lograr este propósito se indicó prótesis inmediata, donde se agrupan etapas del tratamiento, para disminuir tiempo del procedimiento habitual, sin descuidar la calidad. Se logró un trabajo acorde a las exigencias estético-funcionales del paciente, agrupando los pasos de la cirugía bucal y la confección e instalación prótesis inmediata, en tiempo reducido.
Braterstwo w nauczaniu papieża Franciszka
Authors: Kućko Wojciech
Published: October 2020

Czas pandemii koronawirusa i choroby COVID-19 był okazją do postawienia na nowo wielu pytań, dotyczących relacji międzyludzkich. W tym kontekście Papież Franciszek próbuje podjąć terapię braterstwem, aby „globalizacji obojętności” skutecznie i konsekwentnie przeciwstawiać „globalizację braterstwa i solidarności”. Celem artykułu jest ukazanie istoty braterstwa w nauczaniu papieża Franciszka w kontekście nauczania Kościoła katolickiego. W artykule zostają przedstawione biblijne korzenie braterstwa, a także jego inklinacje w magisterium Soboru Watykańskiego II i kolejnych papieży. Reinterpretacja terminu „braterstwo” w myśli Franciszka obejmuje: „mistykę braterstwa”, jego charakter międzyreligijny i społeczny, globalne braterstwo na płaszczyźnie bioetyki i ekologii oraz powiązanie z „teorią przeciwieństw” (niem. Gegensatz), którą papież zaczerpnął od R. Guardiniego.
Cyclosporine A: Chemistry and Toxicity – A Review
Authors: Patocka Jiri , Nepovimova Eugenie , Kuca Kamil , Wu Wenda
Published: October 2020

Cyclosporine A (CsA) is a cyclic undecapeptide with strong immunosuppressive
potency. Firstly marketed in the mid-1980s, CsA was widely used in transplantation and
greatly improved the survival rates of patients and grafts after solid-organ transplantation. Unfortunately,
CsA administration can be associated with a number of side effects due to its high
toxicity. These side effects seriously limited the clinical use of CsA. Therefore, it is important
to understand the serious side effects of CsA in patients, especially in transplantation. In this
review article, the chemistry and most known toxic effects of CsA, including the nephrotoxic,
hepatotoxic, neurotoxic, and cardiotoxic effects, are summarized. Its available toxicity data
(different species, different administration routes), published formerly, are also summarized.
In addition, the molecular pathways of toxicity induced by CsA are also discussed in detail. It
is hoped that this review will help to further understand the source, chemistry, and clinical
application of CsA in patients as well as the potential mechanisms of CsA-induced toxicity.
Evolution of Peptide-Based Prostate-Specific Membrane Antigen (PSMA) Inhibitors: An Approach to Novel Prostate Cancer Therapeutics
Authors: Siow Andrew , Kowalczyk Renata , Brimble Margaret A. , Harris Paul W.R.
Published: October 2020

Background:

Prostate cancer is one of the most common cancers worldwide, with approximately 1.1 million cases diagnosed annually. The rapid development of molecular imaging has facilitated greater structural understanding which can help formulate novel combination therapeutic regimens and more accurate diagnosis avoiding unnecessary prostate biopsies. This accumulated knowledge also provides greater understanding into aggressive stages of the disease and tumour recurrence. Recently, much progress has been made on developing peptidomimetic-based inhibitors as promising candidates to effectively bind to the prostate-specific membrane antigen (PSMA) which is expressed by prostate cancer cells.

Objective:

In this review, recent advances covering small-molecule and peptide-based PSMA inhibitors will be extensively reviewed, providing a base for the rational design of future PSMA inhibitors.

Method:

Herein, the literature on selected PSMA inhibitors that have been developed from 1996 to 2020 were reviewed, emphasizing recent synthetic advances and chemical strategies whilst highlighting therapeutic potential and drawbacks of each inhibitor.

Results:

Synthesized inhibitors presented in this review demonstrate the clinical application of certain PSMA inhibitors, exhibited in vitro and in vivo.

Conclusion:

This review highlights the clinical potential of PSMA inhibitors, analyzing the advantages and setbacks of the chemical synthetic methodologies utilized, setting precedence for the discovery of novel PSMA inhibitors for future clinical applications.
Bacterial Cellulose-Based Metallic Green Nanocomposites for Biomedical and Pharmaceutical Applications
Authors: Badshah Munair , Ullah Hanif , Wahid Fazli , Khan Taous
Published: October 2020

Background:

Bacterial cellulose (BC) is a microbial biosynthesized polymer having exceptional
physical and mechanical features as compared to plants derived cellulose. BC has a wide range of applications
such as traditional dessert as well as gelling, stabilizing and thickening agent in many foods. The more unconventional
applications of BC include but not limited to enzymes immobilization, tissue engineering, artificial
blood vessels and heart valve prosthesis, bone and cartilage regeneration, corneal replacement, skin tissues repair
and dental root canal treatment.

Objective:

This review presents the applications of BC expanded by preparing its nanocomposites with drugs,
fibres, metals and metallic oxides. These nanocomposites have been studied for applications in drug delivery
and biosensors.

Methods:

The current review focuses on the potential applications of BC-based green metallic and metal-based
inorganic nanocomposites as wound dressing material, a tool for microbial control, cardiovascular stenting, and
as bone tissue engineering material. In addition, the potential pharmaceutical applications of BC-based green
metallic nanocomposites have also been discussed.

Results:

The reported BC-based nanocomposites owe advantages in terms of stability, environment friendliness
and cost-effectiveness, prolonged therapeutic effects and biocompatibility with body tissues, with faster wound
healing and negligible cytotoxicity.

Conclusion:

The current review provides a deep insight into the assessment of such nanocomposites in terms
of useful applications and potential commercialization for pharmaceutical as well biomedical purposes.
Exosomes: A Novel Therapeutic Paradigm for the Treatment of Depression
Authors: Bhatt Shvetank , Kanoujia Jovita , Dhar Arghya Kusum , Arumugam Surendar , Silva Amanda K. A. , Mishra Neeraj
Published: October 2020

Extracellular vesicles (EVs) of endocytic origin are known as exosomes. These vesicles
are released by cells and are found in biofluids, such as saliva, urine, and plasma. These vesicles
are made up of small RNA, DNA, proteins, and play a vital role in many physiological processes.
In the central nervous system (CNS), they participate in various physiological processes such as
stress of nerve cells, communication between the cells, synaptic plasticity, and neurogenesis. The
role of exosomes in depression needs to be explored further. It is known that exosomes can cross
the blood brain barrier (BBB), which is made up of glial cells astrocytes. One of the advantages of
these vesicles is that they are able to transfer macromolecules like DNA, protein, mRNAs, and miRNAs
to recipient cells. This review focuses on the potential role of exosomes in depression and
their utilization as a treatment option or diagnostic tool of depression.
Assessment of New E2 Protein Domain Interaction with PKR Protein to Control IFN Signaling
Authors: Dehghani Behzad , Hashempour Tayebeh , Musavi Zahra , Hasanshahi Zahra , Moayedi Javad , Merat Shahin
Published: October 2020

Introduction:

Controversy exists regarding the impact of Phosphorylation Homology
Domain (PePHD) of Hepatitis C Virus (HCV) E2 protein on the interruption of the antiviral signaling
pathway. A mechanism by which the virus evades the antiviral effect of interferon (IFN) alpha
involves protein kinase (PKR) eukaryotic Initiation Factor 2 alpha (eIF2a) PePHD. By binding to
PKR, PePHD inhibits its activity and, therefore, causes the virus to evade the antiviral activity of
IFN. This study aimed to clarify the inconsistency of different conclusions reached in previous
studies using reliable bioinformatics tools.

Methods:

Fifty-eight Iranian patients infected with HCV genotypes 1a and 3a and 58 healthy control
individuals were examined. Plasma viral RNA was used to amplify and sequence the HCV E2
gene; also, HCV viral load, genotyping, IL-28B genotyping, alanine Aminotransferase (ALT), and
aspartate aminotransferase (AST) test were determined. Bioinformatics tools determined the physicochemical
properties, B-cell epitopes, post-modification changes, and secondary/tertiary structures,
and also evaluated the interactions between E2 and PePHD regions.

Results:

The results showed a new domain that is responsible for binding to PKR protein and is important
to the intrigued antiviral response. Physicochemical features and post-modifications were
defined, showing that E2 is highly phosphorylated and there were numerous possible disulfide
bonds. Secondary and tertiary structures for E2 protein were constructed. No significant relationship
between ALT and AST and treatment failure was detected.

Conclusions:

Docking analysis showed a new domain in E2 protein that can be involved in the interaction
between PKR and E2 protein. This finding may justify our results revealing the non-significant
relationship between mutations in PePHD and treatment failure.
Overview of Coumarins and its Derivatives: Synthesis and Biological Activity
Authors: Sahni Tanvi , Sharma Sunita , Verma Diksha , Kaur Pardeep
Published: October 2020

Coumarin is a heterocyclic scaffold and its derivatives, namely Schiff bases, esters, and
hydrazides, etc., play an important role in the field of agrochemical and pharmaceutical industry
due to its structure. Over the years, various biological activities like antifungal, antimicrobial, antiviral,
anti-cancerous, anti-tumor, anti-inflammatory, anti-filarial, enzyme inhibitors, antiaflatoxigenic,
analgesics, antioxidant and Oestrogenic, etc., have been analyzed. This review covers
the latest literature and knowledge on the synthetic procedures for various coumarin and its
derivatives, their biological and pharmacological applications.
Lactides and Lactones Yielding Eco-Friendly and Biocompatible Polymers by Metal-Catalyzed Ring-Opening Polymerization
Authors: Ruelas-Leyva Jose P. , Picos-Corrales Lorenzo A.
Published: October 2020

Currently, there is a growing interest in the development of suitable methods for the
preparation of eco-friendly and biocompatible materials in order to increase environmental protection
and reduce human health risk. Therefore, this mini-review summarizes several studies involving
lactides and lactones as monomers for the synthesis of biodegradable and biocompatible polymers
via metal-catalyzed Ring-Opening Polymerization (ROP). Hence, synthetic approaches involving
mono, bi and trinuclear metallic catalysts, with different catalytic activity, were reviewed.
Complexes mostly based on metals such as Na, Mg, Al, Ti, Zn are considered. Generally, from
ROP reactions, it has been found that conversion, stereoselectivity, number-average molar mass
(Mn) and dispersity of the molar mass (Ð) of polymers are influenced by the type of monomer, the
characteristics of the catalyst, the nature of the solvent, temperature and reaction time. Additionally,
the polymer properties can also be controlled by varying the molar ratios between the monomer
and the initiating system. Thus, this review may be found helpful for the scientific community and
students involved in research in different areas of chemistry such as organic chemistry, inorganic
chemistry, polymers chemistry, and materials science. The survey covers selected data published
between 2017 and 2020; however, previous relevant reports were also studied.
Recent Developments in the Electrochemical Determination of Sulfonamides
Authors: Fu Li , Zhang Xinyi , Ding Su , Chen Fei , Lv Yanfei , Zhang Huaiwei , Zhao Shichao
Published: October 2020

Background:

Sulfonamides are the anti-bacterial and anti-inflammatory drugs synthesized, which are widely used as medical and veterinary antibiotics. However, the excess dosage of sulfonamides can harm human health. Drug residues in animal products also can harm human health through the food chain. The long-term consumption of animal food containing drug residues will cause some toxicity and side effects on human body functions, which will seriously threaten human health.

Methods:

Electroanalytical methods are attracting much attention because of their advantage over conventional methods, as they are quick, low-cost, high sensitivity, and portable. This review examines the progress made in the selective electrochemical determination of sulfonamides in the last 20 years.

Results:

In this review, we describe the development of electrochemical methods for sulfonamides determination. Then, we pay special attention to the detection of sulfonamides using molecular imprinting technology. The linear detection range with the limit of detection has been listed for comparison.

Conclusion:

Electrochemical determination of sulfonamides is a fast, simple, sensitive, and cost-effective approach. The surface modification of commercial electrodes can significantly improve the sensing performance.
Bacterial Cellulose: A Versatile Material for Fabrication of Conducting Nanomaterials
Authors: Mazhar Ul-Islam  , Yasir Sumaiya , Mombasawala Laiqahmed , Manan Sehrish , Wajid Ullah Muhammad
Published: October 2020

Nanomaterials such as nanoparticles, nanorods, nanofibers, and nanocomposites have
received immense consideration and are widely used for different applications in various fields. The
exploration of new synthesis routes, simple processing techniques, and specialized applications are
growing to different fields and bringing extra interest to stakeholders. Bacterial cellulose (BC), a
biopolymer produced by microbial and cell-free systems, is receiving growing applications in various
fields, including medical, energy, environment, food, textile, and optoelectronics. As pristine BC
lacks antimicrobial activity, conducting and magnetic properties, and possesses limited biocompatibility
and optical transparency, its composites with other materials are developed to bless it with such
features as well as improve its existing properties. Herein, we have reviewed the role of BC as a matrix
to impregnate conducting nanomaterials (e.g., carbon nanotubes, graphene, and metals and metal
oxides) and polymers (polyaniline, polypyrrole, and poly (3,4-ethylenedioxythiophene)–poly (styrene
sulfonate)) for the development of composite materials. These BC-based composite materials
find applications in the development of energy storage devices, wearable electronics, biosensors, and
controlled drug delivery systems. We have also highlighted the major hurdles to the industrialization
of BC-based composites and provided future projections of such conducting nanomaterials.
Synergistic Combination of Histone Deacetylase Inhibitor Suberoylanilide Hydroxamic Acid and Natural Flavonoid Curcumin Exhibits Anticancer and Antibacterial Activity
Authors: Altundağ Ergül M. , Toprak Kübra , Şanlıtürk Gizem , Güran Mümtaz , Özbilenler Cahit , Kerküklü Namık R. , Yılmaz Ayşe M. , Yalçın Ahmet S.
Published: October 2020

Background and Objective:

Curcumin is an effective anti-cancer agent used in thyroid cancer treatments.
However, its use in clinical applications is limited due to low solubility and bioavailability. In this study,
a novel combination strategy was applied by combining curcumin with Suberoylanilide Hydroxamic Acid
(SAHA) to increase both bioavailability of curcumin and the efficiency of SAHA, which have limited efficiency
when used alone.

Methods:

MTT assay was used to determine the cell viability of B-CPAP cells upon treatment with SAHA,
curcumin and their combinations. Synergistic interactions between two agents were analyzed by Calcusyn software.
Apoptosis and cell cycle assays were measured by flow cytometry. Expressions of apoptotic and cell cyclerelated
proteins (PARP, P21/CDKN1A/WAF1, P27/KIP1) were examined by western blot analysis. Broth microdilution
assay was performed to determine Minimum Inhibitory Concentration (MIC) values against S. aureus.

Results:

Based on MTT assay, IC50 values for SAHA and curcumin were determined as 0.91μM and 20.97μM,
respectively. The combination index CI value was determined as 0.891 in B-CPAP cells, which demonstrate
synergistic activity. The apoptotic effect was achieved by combination treatment (51.85%) on B-CPAP cells
using half of the dose required for SAHA and curcumin alone. Combination treatment showed a significant
increase in the percentage of B-CPAP cells in the S-phase due to cell arrest. Cleaved-PARP, P21/CDKN1A/
WAF1 and P27/KIP1 protein expressions were upregulated. Curcumin was found to have better anti-microbial
activity than SAHA as having a lower MIC value, and checkerboard synergy analysis revealed that the two
compounds co-operate synergistically for the in vitro killing of S. aureus.

Conclusion:

In the present study, synergistic combinations of SAHA and curcumin were shown to have both
anti-cancer and antibacterial activities that would provide a novel thyroid cancer treatment strategy.
Characteristics of Self-Defining Memories in Middle-Aged and Older Adults
Authors: Cuervo-Lombard Christine , Raucher-Chéné Delphine , Linden Martial Van der , Voltzenlogel Virginie
Published: October 2020

Background:

Self-Defining Memories (SDMs) are a specific type of autobiographical
memory, which play a key role in the construction of personal identity.

Objective:

We investigated the characteristics of SDMs in elderly subjects. The originality of the
present study is to compare our elderly group to middle-aged subjects instead of young adults, as
previously reported in the literature, to understand the age-related modifications in SDMs.

Method:

We recruited 41 elderly subjects with normal cognitive functioning and 37 middle-aged
adults. They were matched for education level and verbal knowledge.

Result:

Older participants recalled the same number of specific memories than middle-aged participants.
SDMs were predominantly constituted of episodic characteristics, with specific details, in
both the groups. However, middle-aged subjects gave more integrative meaning of SDMs and
more redemptive events than older participants. The two samples differed in three content dimensions
(exploration/recreation, relationship contents, and not classifiable). As predicted, older participants
reported memories that were more positive, on average, than the middle-aged participants’
memories.

Conclusion:

Our study added some contributions to the understanding of the consequences of aging
on the sense of self. Future research should explore the continuity of SDMs characteristics
across the lifespan.
Validation of Texas Christian University Psychosocial Functioning and Motivation Scales in Iranian Persons Who Use Drugs
Authors: Shahrabadi Sana , Jalali Amir , Jalali Rostam , Salari Nader
Published: October 2020

Background:

The psychosocial functioning and motivation scales of the Texas Cristian
University (TCU) were translated and validated for the Persons Who Use Drugs (PWUDs).

Methods:

This study was carried out as a methodological research. The scales were translated forward
and backward and then, the PWUDs in Kermanshah-based (west of Iran) substance abuse
treatment centers in 2019 filled out the scales. Participants included 250 individuals who were selected
by convenience sampling method. A demographics form and psychosocial functioning and
motivation scales were used to collect data. For data analysis, content validity, face validity, testretest,
internal consistency, and construct validity were applied by using exploratory analysis methods
in SPSS (v.20) and confirmatory factor analysis in LISREL software.

Results:

Exploratory Factor Analysis (EFA) results were obtained by using the main component
analysis and Varimax rotation of three factors (psychological function, social function, treatment
motivation). Extracted factors, along with the eigenvalues, attributed variance percentage, and cumulative
attributed variances by each factor, by 68.56%, showed a total variance of the questionnaire.
Moreover, the fitness indexes of the Confirmatory Factor Analysis (CFA) of psychological
function, social function, and treatment motivation were 0.059, 0.075 and 0.072, respectively.
Therefore, the questionnaire fitness was at an acceptable level. The test-retest reliability coefficient
was 0.875, and the Cronbach's alpha coefficient for all the components was higher than 0.71.

Conclusion:

The results showed that psychosocial functioning, motivation scales have good psychometric
properties, and they can be used in research and treatment fields.
Free Vibration of Functionally Graded Carbon Nanotube-reinforced Doubly-curved Shells
Authors: Janghorban Maziar , Karami Behrouz
Published: October 2020

Background::

Carbon nanotubes (CNTs) reinforced structures are the main elements of
structural equipment. Hence a wide range of investigations has been performed on the response of
these structures. A lot of studies covered the static and dynamic phenomenon of CNTs reinforced
beams, plates and shells. However, there is no study on the free vibration analysis of a doubly-curved
nano-size shell made of CNTs reinforced composite materials.

Methods::

This work utilized a general third-order shear deformation theory to model the nanoshell
where the general strain gradient theory is used in order to capture both nonlocality and strain gradient
size-dependency. The Navier solution solving procedure is adopted to solve the partial differential
equations (PDEs) and get the natural frequency of the system which is obtained through the
Hamilton principle.

Results::

The current study shows the importance of small-scale coefficients. The natural frequency
increases with rising the strain gradient-size dependency which is because of stiffness enhancement,
while the natural frequency decreases by increasing the nonlocality. In addition, the numerical examples
covered the CNTs distribution patterns.

Conclusion::

This work also studied the importance of shell panel’s shape. It has been observed that
spherical shell panel has a higher frequency compared to the hyperbolic one. Furthermore, the frequency
of the system increases with growing length-to-thickness ration.
The Effect of Unripe Dates (Phoenix dactylifera) on Rat Ovarian Follicle Maturation and Ovulation
Authors: Herlambang Herlambang , Rahman Ave Olivia , Kusdiyah Erny
Published: October 2020

Unripe dates are believed by Indonesian citizens to increase fertility. This study aimed to assess the effect of unripe dates in the ovary of rats. Fresh yellow-colored dates were dried in an oven and crushed into powder. Eighteen rats aged three months and had given birth once were randomly divided into three groups. The treatment groups were given unripe dates at doses of 160mg/kgBW and 320mg/kgBW through a feeding tube for 28 days, and the control group was only given distilled water. Histopathological examination was carried out by the pathology expert using Hematoxylin-Eosin staining to observe the number of ovarian follicles according to their maturation stage. The results showed that the administration of unripe dates powder 320mg/kgBW increased corpus luteum number (21.50Â±4.72) and was statistically significant compared to the control group (15.16Â±3.71). Similar differences were also found in other stages of the follicle although not statistically significant. Administration of unripe date powder can increase ovulation induction among fertile rats.
The Causes of Lack of Pharmaceutical Logistics Monitoring in Surgery Rooms: A Case Study in a Type C Hospital
Authors: Iswari Luh Putu Ayu Pradnya , Youandi Abdi Agus , Indriani Wiwin
Published: October 2020

The surgery rooms have an important role in the hospital, so it must be managed properly. The surgery rooms consume 9% of the annual hospital budget. High operational costs caused by the large cost of human resources, medical materials, and other supporting facilities. This study was conducted in a private hospital type C with 181 beds and has four surgery rooms. The number of patients which was operated in X Hospital was very high, and the highest number in July 2019 reached 515 patients. There were a large supply of drugs and medical devices in the surgery rooms.Â  The number of each drug reached hundreds ampoule, and medical devices reached tens and some in the hundreds. The management of pharmaceutical supplies in the surgery rooms was carried out by senior nurse head of surgery rooms. Monitoring logistic by pharmacy officer only done once a month. This made excessive of stock and become expired. The purpose of this study was to analyze the factors that cause the lack of pharmaceutical logistics monitoring in the surgery rooms. Determination the root of the problem was done by using a fishbone diagram through a Focus Group Discussion with the division heads and subdivision heads of X Hospital. Focus Group Discussion is done by asking the participants one by one to find the root of the problem based on five factors (man, material, method, machine, and environment). Obtained 8 root problems then analyzed with 5 why to get the main root problem. Furthermore, determine the biggest problem using the CARL (capability, accessibility, readiness, and leverage) method, with a weighting score between 1-5. The results found that the absence of pharmaceutical logistics monitoring SOP in the surgery rooms was the most contributing factor to the lack of pharmaceutical logistics monitoring in the surgery rooms.
Numbers and Potential Causes of Medication Error in Inpatient Service of Rumah Sakit Islam Malang
Authors: Arundina Arsy , Widyaningrum Kurnia
Published: October 2020

Medication errors, ranging from prescription to administration errors, are still problems of patient safety with an average error rate of 8% - 10% and can cause severe morbidity, prolonged length of stay (LOS) in a hospital, unnecessary diagnostic tests and care, and mortality. The objective of this study is to describe the number of medication errors and their potential causes according to the perceptions of health personnel. The study was carried out by questionnaires, interviews, and data exploration on prescriptions made before the observation period and new prescriptions made during the observation period. The priority determination of the solutions was carried out using Capability, Assessibility, Readiness, and Leverage method (CARL) and discussions with related units. The priority root factors that caused medication errors in the inpatient pharmacy at RSI Malang were high workloads and high turnover of inpatient pharmacist, incomplete prescription identity, illegible doctor's writing, and lack of training for the pharmacist. The priority outcome of the alternative solutions to overcome the medication errors in inpatient pharmacist is to regularly conduct training or knowledge refreshing for the inpatient pharmacist at RSI Malang and the implementation of e-prescription.
КЛІНІКО-ГІСТОЛОГІЧНІ Й ІМУНОГІСТОХІМІЧНІ ЗІСТАВЛЕННЯ ОСОБЛИВОСТЕЙ УРАЖЕННЯ ШКІРИ У ХВОРИХ НА ВІТИЛІГО
Authors: Цепколенко В. О. , Карпенко К. С.
Published: October 2020

Резюме. Вітиліго – це придбане ідіопатичне захворювання, що характеризується наявністю чітко окреслених депігментованих плям у результаті прогресуючої втрати меланоцитів. Актуальність проблеми пов'язана з вираженим негативним впливом на психологічний стан пацієнтів, значною кількістю хворих молодого репродуктивного віку та відсутністю надійних терапевтичних алгоритмів.
Мета роботи: вивчити гістологічні та імунно-гістохімічні зміни ураженої шкіри у хворих на вітиліго і виявити гендерні їх особливості.
Методи. Під нашим спостереженням перебувало 107 хворих на вітиліго у віці від 19 до 65 років, з них 45 чоловіків і 62 жінки. Проведено морфологічні, імуногістохімічні і морфометричні дослідження ураженої шкіри у 107 хворих.
Результати дослідження. Зіставлення проведених комплексних клініко-гістологічних та імуногістохімічних досліджень виявило відсутність або недостатню кількість меланоцитів в ділянках ураженої шкіри, дистрофічні зміни кератиноцитів, необхідних для регулювання росту і диференціації меланоцитів. Виявлені зміни служать обґрунтуванням використання в лікуванні хворих на вітиліго клітинних технологій, спрямованих на заповнення недостатньої кількості меланоцитів в ураженій шкірі та відновлення нормального функціонування кератиноцитів.
Висновки. Проведені дослідження показали, що у хворих на вітиліго присутні зміни в епідермісі: гіперкератоз, акантоз, вогнищевий гранульоз; в дермі – помірні судинні реакції, вогнищеві лімфогістіоцитарні інфільтрати, характерним для яких було значне число CD3 клітин і переважання CD4 клітин над CD8. Показані гендерні особливості цих змін. Використання специфічного фарбування показало відсутність меланоцитів в епідермісі всіх досліджуваних випадків, що є характерним для вітиліго, і виявлення поодиноких клітин Лангерганса в дермальному інфільтраті.
ДЕЯКІ ПИТАННЯ ХІРУРГІЧНОЇ ТАКТИКИ В ЛІКУВАННІ ПІГМЕНТНИХ НЕВУСІВ У ДІТЕЙ
Authors: Конопліцький В. С. , Пасічник О. В. , Калінчук О. О. , Конопліцький Д. В. , Блажко С. С.
Published: October 2020

Резюме. Стаття містить актуальну інформацію щодо діагностики та лікування дітей з меланоцитарними невусами, форми яких зустрічаються найчастіше, з вказівкою на їх динамічну еволюцію з часом. Обговорюються фактори ризику та питання ранньої діагностики меланоми в загальній практиці. Також обговоренню підлягає сучасне розуміння ризиків, пов’язаних з вродженими меланоцитарними невусами різних розмірів, і стратегії лікування дітей з вродженими і набутими меланоцитарними невусами.

Метою дослідження було підвищення якості лікування дітей шляхом уточнення показів і методів хірургічного лікування  пігментних невусів шкіри.

Пігментні невуси відносяться до доброякісних утворень, виникнення яких на сучасному етапі пов’язують з міграцією в ембріональному періоді меланобластів із нейроектодермальної трубки в базальний шар епідермісу. У дітей пігментні невуси зустрічаються досить часто в будь-якому віці. Так у новонароджених пігментні невуси зустрічаються в 1–6% загальної популяції. Покази до профілактичного видалення невусів витікають із проведеного аналізу клінічного матеріалу: наявність симптомів активації, зокрема ріст невуса; наявності в анамнезі факторів, що сприяють активації пігментних невусів – підвищена сонячна інсоляція, травматизація, зміна гормонального фону; наявність ознак клітинної проліферації; наявність вогнища термонагріву в проекції пігментного невуса. Обов’язковою умовою виконання операції повинно бути проведення морфологічного дослідження. Об’єм тканин, що видаляються, залежить від форми росту, розмірів невуса.
КОМПЛЕКТ ДИАГРАММООБРАЗУЮЩИХ СВЧ ИС ДЛЯ ПРИЕМОПЕРЕДАЮЩИХ МОДУЛЕЙ Х-ДИАПАЗОНА С АФАР НА ОСНОВЕ ОТЕЧЕСТВЕННОЙ 90-НМ КМОП-ТЕХНОЛОГИИ
Authors: Бабак Л.И. , Панасенко П.В. , Коколов А.А. , Помазанов А.В. , Шутов Е.С. , Коряковцев А.С. , Федоров Е.А. , Шеерман Ф.И.
Published: October 2020

Представлен комплект диаграммообразующих СВЧ ИС для приемопередающих модулей Х-диапазона с АФАР на основе отечественной 90-нм радиочастотной КМОП-технологии в составе 6-битных управляемых фазовращателя и аттенюатора, а также буферного усилителя. Исследована точность моделей СВЧ-элементов в библиотеке для используемой технологии.
РАДИАЦИОННО-ОРИЕНТИРОВАННАЯ И СВЧ-ХАРАКТЕРИЗАЦИЯ ТЕХПРОЦЕССОВ КОНТРАКТНОГО ПРОИЗВОДСТВА ЭКБ ТСВЧЭ, ИСПОЛЬЗУЕМЫХ ОТЕЧЕСТВЕННЫМИ ДЦ: СОСТОЯНИЕ, ПРОБЛЕМЫ И БЛИЖАЙШИЕ ЗАДАЧИ
Authors: Елесин В.В. , Сотсков Д.И. , Усачев Н.А. , Кузнецов А.Г. , Селецкий А.В. , Фазылханов О.Р. , Филаретов А.Г.
Published: October 2020

Рассмотрены состояние и проблемные вопросы контрактного производства ЭКБ ТСВЧЭ, представлены результаты характеризации ряда отечественных и зарубежных техпроцессов, пригодных для разработки радиационно стойких приемопередающих ИС с рабочими частотами до 30 ГГц.
Astrid Windus, Afroargentinier und Nation. Konstruktionsweisen afroargentinischer Identität im Buenos Aires des 19. Jahrhunderts, Leipzig, Leipziger Universitätsverlag, 2005, 327 pp.
Authors: Bock Ulrike
Published: October 2020

Reseña del libro:Astrid Windus, Afroargentinier und Nation. Konstruktionsweisenafroargentinischer Identität im BuenosAires des 19. Jahrhunderts, Leipzig, LeipzigerUniversitätsverlag, 2005, 327 pp.
PLAN COLOMBIA: ¿ESTADOS UNIDOS ANTE UN NUEVO ENEMIGO EN AMÉRICA LATINA?
Authors: Ramírez-Orozco Mario
Published: October 2020

Una visión crítica de las consecuencias de la políticaantiterrorista de Estados Unidos con respecto a América Latina, luegodel 11 de septiembre de 2001, demuestra que la implantación delPlan Colombia, bajo el gobierno de Andrés Pastrana y su continuidaddurante la administración de Álvaro Uribe, significó no sólo la pérdidade autonomía en la política antinarcóticos sino la narcotización total dela lucha contrainsurgente, con el consecuente escalamiento del conflictoarmado que azota a Colombia por varias décadas. Este plan deíndole militar propició, además, el intervencionismo directo de EstadosUnidos en Colombia y en la región andina y amazónica como unaforma de control sobre los grandes recursos naturales, en particularde los yacimientos petroleros de Colombia, Ecuador y Venezuela.PALABRAS CLAVE: Plan Colombia; Conflictos armados; Paz; Lucha
Tiempo-espacio en la constitución estatal. Una perspectiva desde la sociedad costarricense
Authors: Huaylupo Alcázar Juan
Published: October 2020

El autor analiza las dimensiones tiempo-espacio para estudiarla constitución histórica y social de éste, como un requisito para comprender las regresivas transformaciones del Estado, en particular del costarricense.La integración social es, para el autor, la gestación de un poderque trasciende las visiones y prácticas unilaterales, así como la asignacióninédita al Estado del respeto y representación de los derechos e interesesciudadanos. La constitución social del Estado fue la inauguraciónde lo público, de la política pública y de los proyectos nacionales, sin embargo,en el presente mundializado, la reforma del Estado y de la administraciónpública han sido los medios para autonomizar su función social,para privatizar lo público y lo nacional, así como los recursos y propiedadesde la sociedad. La reconstitución social del Estado es una necesidadpara revertir la supeditación de lo público al poder privado.
Íñigo Abbad y Lasierra, Diario del viaje a América, ed. de Juan J. Nieto y José M. Sánchez, Madrid, Miraguano Ediciones, 2003, 334 pp. (Viajes y costumbres)
Authors: Escandón Patricia
Published: October 2020

Reseña del libro: Íñigo Abbad y Lasierra, Diario del viaje a América, ed.de Juan J. Nieto y José M. Sánchez, Madrid, MiraguanoEdiciones, 2003, 334 pp. (Viajes y costumbres).
El latinoamericanismo de José Martí
Authors: Saladino García Alberto
Published: October 2020

Uno de los aportes centrales de José Martí lo constituye, porel carácter aglutinador de sus inquietudes gnoseológicas como reivindicativas,su latinoamericanismo, el cual elevó al rango de principio y razónde su vida. Teóricamente sustanció el latinoamericanismo como libertario,lo fundamentó en la recuperación de nuestro pasado y en el rigurosoconocimiento de la realidad para posibilitar la independencia mental, yrespaldar la unidad de los países de la región. Su actitud humanista laevidenció al invocar el uso de los avances científicos y técnicos. Acercade su praxis latinoamericanista deben destacarse sus acciones relacionadascon la concreción de los ideales bolivarianos, las alternativas de solución con laexploración de los avances del conocimiento y la entrega de su vida mismaal servicio de la liberación.En otras palabras resignificó el latinoamericanismo, el cual popularizó conla expresión nuestra América.
Las representaciones indígenas y la pugna por las imágenes. México y Bolivia a través del cine y el video
Authors: Nahmad Rodríguez Ana Daniela
Published: October 2020

En este texto se analizan las construcciones visuales formuladassobre los grupos originarios latinoamericanos, enfatizando la existencia actualde una lucha por las representaciones, ya que en ellas se sintetizanejercicios de poder y dominación. Este fenómeno se contrasta con la resistenciaque los grupos indígenas han emprendido ante la colonialidad de lasimágenes, mediante el manejo de los medios de comunicación audiovisual.Se tejen las relaciones entre política, cultura e imagen para demostrar elconflicto de los indígenas latinoamericanos frente a las hegemonías culturalesy económicas.
Agustín Sánchez Andrés, El Ministerio de Ultramar. Una institución liberal para el gobierno de las colonias, 1863-1899, Santa Cruz de Tenerife, México, Universidad Michoacana de San Nicolás de Hidalgo, México, Centro de la Cultura Popular Canaria, 2007 (Taller de Historia, 44).
Authors: Camacho Navarro Enrique
Published: October 2020

Reseña del libro:Agustín Sánchez Andrés, El Ministerio de Ultramar.Una institución liberal para el gobierno de las colonias,1863-1899, Santa Cruz de Tenerife, México, UniversidadMichoacana de San Nicolás de Hidalgo, México,Centro de la Cultura Popular Canaria, 2007 (Taller deHistoria, 44).
Los márgenes del discurso. Voces y silencios en La máquina de escribir (1996), de Juan Martini
Authors: Tozzi Liliana
Published: October 2020

En La máquina de escribir (1996) de Juan Martini se presenta un discurso fragmentado, que reproduce el tono y el ritmo de las conversaciones en el ámbito de un bar. La proliferación de voces inscribe en el texto parte de los discursos sociales del siglo XX y da cuenta de las tensiones sociales que se generan, especialmente a partir de las políticas neoliberales de los años noventa en Argentina. En este trabajo me propongo analizar, desde un enfoque sociocrítico, algunos de los modos en los que ingresa la dimensión social en la novela: la revisión del pasado, la circulación del poder y la visión crítica de la realidad social y económica de finales del siglo XX.
La Fragua. Ejemplo transversal de química, música y artes plásticas
Authors: Fernández Manzano Reynaldo , Fernández Barbosa Eva Luz
Published: October 2020

Dentro de las actividades pedagógicas transversales que se pueden realizar entre diferentes materias en este caso nos centramos en relacionar la química con la música, el arte y la historia, a través del ejemplo de la fragua.
Destinado a los profesores para que después ellos adapten los contenidos según el nivel de sus estudiantes. Se analizarán los siguientes apartados: 1. Metodología y aspectos pedagógicos, 2. Los ritos de los herreros de la Prehistoria, 3. La fragua en la construcción de los inicios de la teoría musical, 4. La fragua fuente de inspiración musical, 5. La fragua en el flamenco: “El Martinete” y 6. Epílogo. La fragua en Velázqu
Diversity of Arbuscular Mycorrhizal Fungi in Shola Forests of Kodaikanal, Southern India
Authors: Kullaiyan Sathiyadash  , Jaffer Ali Jabeen  , Karthigai Selvi Ezhilarasi  , Eswaran Pillai Uma
Published: October 2020

Arbuscular mycorrhizal fungi establish symbiotic association with more than 80% of land plants and influence plant community composition and distribution. The mycorrhizal status of plant species in various ecosystems have been reported but failed to assess community composition of AM fungi in shola forests, therefore present study carried out to fulfill this research gap.  A  total  of  Seven  AM  fungal  species  could  be  isolated  from  Tiger  and  Kookal  shoal  and  identified  based  on  spore morphology. There is no significant difference among distribution of AM fungal spores in various seasons among sites. In both the sholas AM fungal spore numbers were high during the wet (September) season and the variation among spore numbers in different seasons among sites were insignificant. Arbuscular mycorrhizal spore of Funneliformis geosporum was the most frequent species and Funneliformis mosseae was the less frequent species. The frequency among various sites in both the Sholas was insignificant. The AM fungal species richness was high in Tiger Shola (six spores), whereas in Kookal Shola showed less species richness. The diversity indices like Shanon - Weaver index (H') and Simpson index (D) were calculated in all the sites and showed variation among shoals in four sites. Arbuscular mycorrhizal fungal community composition in this ecosystem have been elucidated to certain extent and used for conservation of shola species.