bluuebunny/crossref_metadata_2025 huggingface dataset:
Application for Selling Cuisine at Padang X Restaurant Based on Web
Authors: Nabila Maulina
Published: August 2023

This Padang X restaurant was founded about 2 years ago, and is located on Jl. Pangeran No.136 Bekasi. This location is chosen because it is an area surrounded by offices such as village offices, sub-districts, and banks. So this place is a strategic place to be established restaurants. To provide good service to consumers, Padang X restaurant needs to know what is expected from consumers. In addition, X restaurant also needs to pay attention to the services provided to consumers so that if consumers are satisfied with the service they have received, consumers will still choose restaurants in Sabana Minang compared to other restaurants. So, the quality of service services is very important to note because it is closely related to consumer satisfaction Tekhnik data collection by looking directly at the survey to the field and dealing directly with activities that are directly involved in the sale of padang X restaurants.
The Effect Of Perceived Organization Support and Work Motivation On Employee Engagement In Improving Employee Performance At Regional Revenue Agency In Tegal Regency
Authors: Putra Setya Yurissa , Raharja Edy
Published: August 2023

The purpose of this research is to test the influence of perceived organizational support, and work motivation on employee engagement to impact employee performance. Using these variables, the use of these variables is able to solve the problems arising withinemployees of the Regional Revenue Agency of Tegal Regency. The statement of this problem is how to increase employee performance?.

The sample size of this research is 44employees of the Regional Revenue Agency of Tegal Regency. Using the Smart PLS (Path Least Square). The results show that perceived organizational support and work motivation on employee engagement impact employee performance.

The effect ofperceived organizational supporton employee engagement are significant;the effect ofwork motivationon employee engagement are significant;the effect ofperceived organizational supporton employee performance are significant;the effect ofwork motivation on employee performance is significant;the effect ofemployee engagementon employee performance is significant.
The Effect of Green Credit and Other Determinants of Credit Risk Commercial Bank in Indonesia
Authors: Nugrahaeni Ressita , Muharam Harjum
Published: August 2023

In order to achieve the Notionally Determined Contribution (NDC) target through reducing greenhouse gas emissions, the Government of Indonesia is trying to develop sustainable finance. Commercial Banks as a financial service institution are required to implement sustainable finance, among others by reporting loans that meet the criteria for Environmentally Friendly Business Activities (KUBL). Credit risk is one of the main risks for banks. Research on the effect of lending that meets KUBL or green loan criteria on bank credit risk as reflected in NPLs has never been carried out. In this study, we analyze the effect of green loans, and the influence of other variables, namely bank performance variables (LDR, CAR, ROA, NIM) and bank size on credit risk of commercial banks in Indonesia. This study uses annual available data from 107 commercial banks in Indonesia for the period from 2019 to 2021. Based on the results of this study, the effect of green loans on NPL is not significant because the percentage of green loans is relatively low compared to the total bank credit portfolio in Indonesia. For this reason, various incentives are needed from both the Authority and the Government to encourage commercial banks to increase green loans.Meanwhilebank performance variables, namely LDR, CAR, NIM and bank size have a significant influence on the credit risk of commercial banks in Indonesia. Bank performance variables namely LDR, CAR have a positive effect on bank NPLs, the NIM ratio and bank size have a negative effect on bank NPLs.
What interacting with publishers felt like for this open access proponent
Authors: Brembs Björn
Published: August 2023

At various meetings I get often asked by early career researchers, librarians or other colleagues what my interactions with publishers felt like. I usually answer that my last twelve years campaigning for infrastructure reform felt like academia was receiving the big middle finger from publishers: No matter what you try, academia, we’ll still get your money, stupid suckers!
How to write your grant proposal?
Authors: Brembs Björn
Published: August 2023

Posting my reply to a review of our most recent grant proposal has sparked an online discussion both on Twitter and on Drugmonkey’s blog. The main direction the discussion took was what level of expertise to expect from the reviewers deciding over your grant proposal. This, of course, is highly dependent on the procedure by which the funding agency chooses the reviewers.
Nomenclature for data publications and citations
Authors: Shotton David M.
Published: August 2023

The meaning of the word “dataset” is ambiguous, changing with context.
More record breakers for the anomeric effect involving C-N bonds.
Authors: Rzepa Henry
Published: August 2023

An earlier post investigated large anomeric effects involving two oxygen atoms attached to a common carbon atom. A variation is to replace one oxygen by a nitrogen atom, as in N-C-O. Shown below is a scatter plot of the two distances to the common carbon atom derived from crystal structures. You can see some entries for which the C-O bond length is shorter than normal and the C-N distance very much longer than normal;
Announcing the Research Centre for Open Scholarly Metadata and the International Advisory Board for OpenCitations
Authors: Peroni Silvio
Published: August 2023

As mentioned in an earlier blog post, OpenCitations has been selected by SCOSS for its second round of crowd-funding support from stakeholders within the open scholarship community.
DataCite2RDF – Mapping DataCite Metadata Scheme Terms to ontologies
Authors: Shotton David M.
Published: August 2023

The DataCite Metadata Kernel version 2.0 [1] specifies the minimal metadata, and optional metadata, that should accompany a DataCite DOI for the identification of a published data entity. Within the Metadata Kernel document there is an XML mapping of these metadata terms, using DCMI Metadata Terms, and an example encoded in XML.
Data Diving for Genomics Treasure
Authors: Brembs Björn
Published: August 2023

This is a post written jointly by Nelson Lau from Brandeis and me, Björn Brembs. In contrast to Nelson’s guest post, which focused on the open data aspect of our collaboration, this one describes the science behind our paper and a second one by Nelson, which just appeared in PLoS Genetics.

Laboratories around the world are generating a tsunami of deep-sequencing data from nearly every organism, past and present.
How to employ CiTO in CiteULike
Authors: Shotton David M.
Published: August 2023

Jodi Schneider of DERI has posted on her blog at http://jodischneider.com/blog/2010/10/18/cito-in-the-wild/ a most helpful description of how to employ CiTO properties characterizing bibliographic citations as tags for references in CiteULike. Thanks, Jodi!
Chance in animate nature, day 3
Authors: Brembs Björn
Published: August 2023

On our final day (day 1, day 2), I was only able to hear Boris Kotchoubey‘s (author of “why are you free?“) talk, as I had to leave early to catch my flight. He made a great effort to slowly introduce us to nonlinear dynamics and the consequences it has for the predictive power of science in general.
How do academic publishers see their role?
Authors: Brembs Björn
Published: August 2023

Over the years, publishers have left some astonishingly frank remarks over how they see their role in serving the scholarly community with their communication and dissemination needs. This morning, I decided to cherry-pick some of them, take them out of context to create a completely unrealistic caricature of publishers that couldn’t be further from the truth.
Is cyanogen chloride (fluoride) a source of C⩸N(+)?
Authors: Rzepa Henry
Published: August 2023

In 2010 I recounted the story of an organic chemistry tutorial, in which I asked the students the question “

how would you synthesize 3-nitrobenzonitrile

”. The expected answer was to generate a nitronium ion to nitrate benzonitrile, but can one invert this by generating a C⩸N

+

ion to cyanate nitrobenzene?
COCI has surpassed 700M citations
Authors: Peroni Silvio
Published: August 2023

We are excited to share that COCI, the OpenCitations Index of Crossref open DOI-to-DOI citations, was on 12 May 2020 extended with more than 47 million additional citations, and has reached a total number of more than 702 million DOI-to-DOI citation links between more than 58 million bibliographic entities. The citations added in this the fifth release of COCI came from the most recent Cros
Don’t be afraid of open data
Authors: Brembs Björn
Published: August 2023

This is a response to Dorothy Bishop’s post “Who’s afraid of open data?“. After we had published a paper on how Drosophila strains that are referred to by the same name in the literature (Canton S), but came from different […] ↓ Read the rest of this entry...
How gold open access may make things worse
Authors: Brembs Björn
Published: August 2023

Due to ongoing discussions on various (social) media, this is a mash-up of several previous posts on the strategy of ‘flipping’ our current >30k subscription journals to an author-financed open access corporate business model. I consider this article processing charge (APC)-based version of ‘gold’ OA a looming threat that may deteriorate the situation even beyond the abysmal state scholarly publishing is already in right now.
Choreographing a chemical ballet: what happens if you change one of the actors?
Authors: Rzepa Henry
Published: August 2023

Earlier, I explored the choreography or “timing”, of what might be described as the curly arrows for a typical taught reaction mechanism, the 1,4-addition of a nucleophile to an unsaturated carbonyl compound (scheme 1). I am now going to explore the consequences of changing one of the actors by adding the nucleophile to an unsaturated imine rather than carbonyl compound (scheme 2).  **
Should public institutions not be choosing the lowest responsible bidder?
Authors: Brembs Björn
Published: August 2023

Public institutions the world over are required to spend their funds responsibly. Commonly, this is done by requiring them to host bids for purchases or services above a certain threshold. If you work at a public institution and have wondered, e.g., why you are only allowed to buy a computer from your computing facility which only sells one particular brand, then the answer likely is that this brand won the bidding contest.
Changes of serum MMP-9, NSE, MPO levels and prognostic influencing factors in patients with intracranial aneurysm undergoing interventional embolization at different treatment timing
Authors: Wu Chunmiao , Dong Xingyu , Li Qiang , Liu Shengming , He Yuhao , Zhang Yang , Zhang Sunfu
Published: August 2023

Background: To analyzes the changes in serum levels of matrix metalloproteinase-9 (MMP-9), neuroenolase (NSE), myeloperoxidase (MPO) and prognostic factors in patients with intracranial aneurysm (IA) undergoing interventional embolization at different treatment times. Methods: A retrospective analysis was made of 200 IA patients admitted to our department from January 2018 to June 2021 was performed. All patients underwent interventional embolization. According to the timing of surgery, the patients were divided into an early group (n=120, onset to surgery ≤72 h) and a delayed group (n=80, onset to surgery >72 h). The effect of embolization, complications and neurological deficit scale (NDS) scores were compared between the two groups. Serum MMP-9, NSE and MPO levels were compared before and after surgery, and the prognosis of all patients within 2 years after surgery was assessed by the Glasgow outcome scale (GOS) and divided accordingly into the good prognosis group (n=147) and the poor prognosis group (n=53) accordingly, and the prognostic factors influencing the patients were analyzed univariately and multifactorially. Results: After surgery, the rate of complete embolism was higher in the early group than in the delayed group (P<0.05). After surgery, there was no statistical significance in the comparison of the individual complication rates in both groups (P>0.05). At 3d, 1 month, and 6 months after surgery, the NDS scores of patients in both groups were lower than those before surgery, and the within-group comparison of the NDS scores of patients in both groups at different time points was statistically significant (P<0.05). After surgery, serum MMP-9, NSE, and MPO levels were lower in both groups than before surgery, and they were lower in the early group than in the delayed group (P<0.05). GOS results showed that within 2 years after surgery, there were 97 and 23 cases with good and poor prognosis in the early group and 54 and 26 cases with good and poor prognosis in the delayed group, respectively, and the good prognosis rate in the early group was higher than that in the delayed group (P<0.05). Multifactorial analysis showed that delayed surgery, aneurysm in the posterior circulation, aneurysm neck width >4.5 mm, Fisher grade III-IV, Hunt-Hess grade III-IV, and hypertension were all independent risk factors for poor prognosis after IA interventional embolization (P<0.05). Conclusion: Early interventional embolization in IA patients can improve their complete embolization rate and reduce serum MMP-9, NSE, and MPO levels; delayed surgery, aneurysm in the posterior circulation, aneurysm neck width >4.5 mm, Fisher grade III-IV, Hunt-Hess grade III-IV, and hypertension are strongly associated with poor prognosis after interventional embolization in IA patients.
A teoria do prazer na introdução à Crítica da Faculdade do Juízo
Authors: Citro Danilo
Published: August 2023

As introduções à Crítica da Faculdade do Juízo são os primeiros textos desta obra em que Kant se refere ao prazer, antes de iniciar a análise da faculdade de ajuizar o belo por meio deste sentimento, isto é, o gosto. Kant apresenta um quadro das faculdades da alma, segundo o qual o prazer tem a função de fazer uma transição entre a faculdade de conhecimento e a faculdade de apetição. Propomos uma análise da teoria do prazer apresentada pelo filósofo nas introduções.
Reflexão e autonomia: uma relação entre juízo de gosto e crítica de arte.
Authors: Mattos Júlia Casamasso
Published: August 2023

Tal artigo pretende analisar a autonomia presente no juízo de gosto kantiano a fim de compreender como tal juízo pode servir de base para a crítica de arte. Procuraremos mostrar que julgando de forma autônoma o sujeito está provando o seu gosto, assim como o crítico que procura exprimir uma reflexão genuína sobre a obra de arte. Podemos entender que ambos procuram, não só pelo equilíbrio entre a força de se afirmar e a possibilidade de sustentar se em frente a juízos contrários, mas também pela justa medida entre gosto e subjetivismo.
Rorty lendo Proust: Verdade e palavras-sagradas versus contingência e ironia
Authors: Lopes Marcos Carvalho
Published: August 2023

Descreverei nesse artigo como Rorty lê Proust, tomando Em busca do tempo perdido como um substituto para a Alegoria da Caverna de Platão. O protagonista de Proust precisa abandonar a busca pela Verdade e seu encanto por palavras-sagradas, assumindo a contingência e aprendendo a rir de si mesmo. Por fim, pretendo mostrar como Rorty constrói um paralelo entre a narrativa de Proust e o caminho de crítica de metafísica que parte de Hegel, passa por Nietzsche, Heidegger e chega a Derrida.
O pensar da identidade e a identidade do pensar
Authors: Canto Rafael Estrela
Published: August 2023

Resumo: O tema do artigo é a evidência do princípio de identidade, incluindo o seu papel na formação de uma “imagem” do que sejam o pensar e o pensado correlato. Ele é, na verdade, um composto de reflexões sobre o tema, sem propriamente nenhuma conclusão.Palavras-chave: Identidade; Elaborar; Razão.Abstract: The paper is about the evidence of the principle of identity, including its role in the development of some “image” of what is thought and what is under this thought. It is actually a composition from reflections about the subject without any conclusion.Keywords: Identity; To Elaborate; Reason.
A restituição impossível: o abandono a si da pintura.
Authors: Hermes Ana Luiza Fay
Published: August 2023

Resumo: Este ensaio procura compreender a análise que Derrida empreende acerca do debate em torno da pintura “Par de Sapatos” de autoria de Vincent van Gogh que envolveu o filósofo Martin Heidegger e o historiador da arte Meyer Schapiro. Em sua análise Derrida elabora uma reflexão acerca das problemáticas da representação e da verdade em pintura.Palavras-chave: Derrida, Heidegger, Schapiro, representação, pinturaAbstract: This essay seeks to understand the analysis that Derrida undertakes on the debate around the painting “Pair of Shoes” by the artist Vincent van Gogh. The debate involves the philosopher Martin Heidegger and the art historian Meyer Schapiro. In his analysis Derrida develops a reflection on the issues of representation and the truth in painting.Keywords: Derrida, Heidegger, Schapiro, representation, painting
Entre acontecimentos: Deleuze e Derrida
Authors: De Figueiredo Fernando Padrão
Published: August 2023

Resumo: O presente texto tem por objetivo traçar uma relação entre Gilles Deleuze e Jacques Derrida através da noção de acontecimento. Para estes, problematizar o pensamento, torná-lo acontecimento, não é melhor capacitá-lo para conhecer seu objeto intimamente, nem demarcar os limites legais das faculdades subjetivas do homem, mas se faz a partir de outra “lógica”, onde o possível e o impossível devêm um e outro, i. e., os dois ao mesmo tempo.Palavras-chaves: Acontecimento; Gilles Deleuze; Jacques Derrida.Abstract: This work's proposal is to draw a relationship between Gilles Deleuze e Jacques Derrida through the notion of event. For them, analyze the images of thought is kind of problematization, where the task is not enable him to know your own objects intimately, even demarcate the legal limits of the subjective faculties of man, but is required another “logic”, where the possible and impossible can be considered both at the same time.Keywords: Event; Gilles Deleuze; Jacques Derrida.
Um estudo sobre o uso de expressões figuradas no texto filosófico: Heidegger e o conceito metafórico
Authors: Gurgel Diogo De França
Published: August 2023

Resumo: O artigo é parte de uma pesquisa sobre o estatuto de sentenças filosóficas nas quais ocorre um uso figurado da linguagem. Parto da análise da sentença heideggeriana “o pensamento é um ouvir e um ver”, apresentada no texto O princípio de razão. Faço essa análise à luz de algumas teorias contemporâneas da metáfora, de modo a desabilitar a associação feita por Heidegger entre metáfora e tradição metafísica.Palavras-chave: gramática; metáfora; pensamentoAbstract: The article is part of a research on the status of philosophical sentences in wich occurs a figurative use of language. My starting point is an analysis of HeideggerÂ´s sentence “thinking is a hearing and a seeing” which is displayd on the text The principle of reason. I base this analysis in some contemporary theories of metaphor, in order to disable the association made by Heidegger between metaphor and metaphysical tradition.Keywords: grammar; metaphor; thought
Da existência do útil ao inútil: a constituição do instrumento na ordem da obra de arte
Authors: Da Silva Kibson Rodrigo Santos
Published: August 2023

Resumo: O que se pretende neste texto é fazer uma análise prévia sobre a constituição do instrumento (utensílio), sobre sua natureza, e sua essência para chegar até a concepção do que seria o instrumento, possibilitando o advir da obra de arte. Com isto, torna-se necessário definir o que faz aparecer e constituir o instrumento a partir do acontecer de sua instrumentalidade. Para este exame, as obras principais são Ser e tempo e A origem da obra de arte.Palavras-chave: Heidegger; Necessidade; Utilidade.Summary: The intention in this text is to make a preliminary analysis about the constituition of the instrument (tool), its nature, its essence to achieve the conception of wath would be the instrument, allowing the coming of the artwork. This requires defining what is does appear and constitute the instrument from the happening of its instrumentality. For this exam, the main works are Being and Time and The origin of the artwork.Keyworks: Heidegger; Need; Utility
Caracterizando o realismo moral
Authors: Oliveira Marco
Published: August 2023

Nos últimos 30 anos o realismo moral tornou-se um dostemas mais debatidos em metaética. A posição ganhou novosdefensores, bem como novas abordagens, em especial emcomemoração aos 100 anos de Principia Ethica. Entretanto, ainda nãohá consenso sobre como caracterizar corretamente uma posiçãorealista moral. O presente trabalho tem por objetivo apresentar algunsproblemas levantados por críticos com relação a objetividade que essaposição defende.
Notas sobre o tema da morte e o paradoxo do suicídio em Spinoza
Authors: Magalhães Alcina
Published: August 2023

Este artigo apresenta uma reflexão sobre como a “Ética” de Spinoza, que é uma sabedoria para a vida, um “viver para a eternidade”, pode ser útil quando se quer compreender o tema da morte e o paradoxo do suicídio.
Resumos
Authors: Doutorado 2013 Defesas
Published: August 2023

Doutorando:

Alexandre da Silva Costa

Ana Luiza da Gama e Souza

Catarina Alves dos Santos

Mariângela Areal Guimarães

Marcos Carvalho Lopes
Democracia, liberdade e poesia: a grande revolução popular de Atenas
Authors: Facão (PUC-Rio) Emerson
Published: August 2023

Este artigo visa apresentar alguns pontos da crise social que ocorreu entre os séculos VII e VI na Grécia. Esse período turbulento marcou de modo decisivo a história da Grécia. A intervenção do poeta e legislador Sólon foi importante para que cidade de Atenas pudesse estabelecer as primeiras bases para a instauração da Democracia.
Os Elementos Cômicos do Diálogo Platônico
Authors: Neto (UFRJ) Nelson de Aguiar Menezes
Published: August 2023

A pergunta sobre o “ancestral literário” do diálogoplatônico não pode ser respondida sem uma remissão à comédia. Comefeito, dentre os modelos literários dos quais Platão se serviu paracompor um novo gênero, a comédia assume lugar de destaque.Partindo da ideia de que o diálogo platônico constitui um gênerohíbrido, que incorpora outros gêneros literários e os articula num ricodiálogo, este trabalho busca estabelecer uma relação entre o estiloliterário platônico e o modelo cômico de composição dramática.
O Conceito de Linguagem em Nietzsche na obra "Escritos sobre Retórica"
Authors: Haubert Laura Elizia
Published: August 2023

A obra “Escritos sobre Retórica” compõem um dos textos menos estudados pelos intérpretes de Friedrich Nietzsche. Isso ocorreu, boa parte, devido a condição do texto que não foi composto para ser publicado como as obras oficiais, mas que é antes uma reunião das notas que Nietzsche utilizava para dar aula durante sua estadia na Universidade da Basileia, não obstante essa condição, é uma das obras de maior auxílio para a compreensão do tema da linguagem no filósofo alemão. O presente artigo visa compreender estas notas a partir de uma exposição ampla de seu contexto de produção, seguindo para o problema qual o filósofo se dedicava, e por fim averiguar em específico o tema da linguagem e da metáfora e seus significados e conceitos nesta obra.Palavra-Chave: Linguagem. Retórica. Metáfora. Tropos.
Liberalismo, Governamentalidade e Seguridade
Authors: Almeida André Pereira de
Published: August 2023

Diante do atual contexto de fortalecimento do pensamento liberal no Brasil e no mundo, resolvi pensar suas estruturas de funcionamento e seus mecanismos de gerenciamento e manutenção da ordem social. Faço assim uma  análise crítica a partir da leitura foucaultiana da governamentalidade, da seguridade e dos liberalismos alemão (ordoliberalismo) e estadunidense (Escola de Chicago), como formas de gerenciamento e controle da população e/ou sociedade civil, a partir dos cursos  Sécurité, territoire, population e Naissance de la biopolitique, ministrados no Collège de France nos biênios de 1977-1978 e 1978-1979, respectivamente.
Aristóteles e a questão da δύναμις desde a ótica de Martin Heidegger
Authors: Santos Manuela
Published: August 2023

Talvez uma das questões mais obscuras legada à história do pensamento seja a questão da δύναμις (dynamis) enquanto tal. Na Física e na Metafísica, Aristóteles parece querer dar a conhecer a imbricação interna que ocorre entre o conceito ontológico e o conceito ôntico de δύναμις , e isto para tentar compreender a que concerne o movimento em essência. Para orientar o curso desta tarefa de reconhecimento da proposta de Aristóteles, elegemos como orientadora do nosso estudo preliminar a perspectiva que o pensador Martin Heidegger propõe acerca do que, para o filósofo contemporâneo, ainda hoje permanece inaudito. Heidegger ensina que o essencial do que para os gregos significava o movimento só é compreendido quando observamos que em uma mudança, algo que até então não era, passa a ser donde surge a fundamental questão de saber acerca das condições de possibilidades do não-ente vir-a-ser. Para o grego, o movimento enquanto uma forma do Ser tem este caráter do “emergir à presença”.
Filosofia africana contemporânea desde os saberes ancestrais femininos: novas travessias / novos horizontes
Authors: Machado Adilbênia Freire
Published: August 2023

Esse artigo traz um breve diálogo acerca da filosofia africana contemporânea refletindo novos caminhos / horizontes, nessa perspectiva busco trazer, brevemente, os saberes ancestrais femininos como mediadores desses novos / outros caminhos. Dialogaremos em torno de uma crítica à ausência das mulheres nas temáticas em torno da filosofia africana, compreendendo que filosofar desde os saberes ancestrais femininos é implicar-se em uma relação intima com nossa humanidade. O feminino é a energia do encantamento, é quem permite o existir com ética, amorosidade, cuidado, o que dá e o que permite a vida, é a ancestralidade perpassando e criando sentidos de re-existências.
O FEMININO E A MATERNIDADE NA PSICANÁLISE FREUDIANA: REFLEXÕES CRÍTICAS
Authors: Becker de Campos Thais , Winograd Monah
Published: August 2023

O presente artigo discute a visão freudiana de feminilidade e maternidade. Propõe-se, inicialmente, uma contextualização sócio-histórica de Sigmund Freud (1856-1939). Destacam-se como influências importantes nos escritos do autor, a cultura patriarcal, as ideias iluministas de complementaridade e o ideal romântico de feminilidade. O artigo analisa como estas influências aparecem na teoria freudiana sobre o feminino. É realizado um estudo sobre o conceito de Complexo de Édipo para a realização de uma análise crítica da visão freudiana sobre o que seria um desenvolvimento saudável da feminilidade, que envolveria a realização da maternidade como destino ideal.
Historical Background of Kawasaki Disease in Korea
Authors: Han Ji Whan
Published: August 2023

The first 50 cases of Kawasaki disease (KD) were reported in 1967 by Dr. Tomisaku Kawasaki. In Korea, Park et al. reported the first 5 cases of KD in 1973. In 1970, the Japanese Kawasaki Disease Research Committee was established with support from the Ministry of Health, Labour and Welfare of Japan and conducted the first Japanese nationwide epidemiological survey on KD that same year. In Korea, the first epidemiological study on KD was conducted by Lee et al. in 1982. The first nationwide epidemiological survey on KD in Korea was conducted by Yoon et al. from 1991 through 1993 and has been subsequently conducted every three years. The Korean Kawasaki Disease Study Group was founded in 2003 under the Korean Pediatric Heart Association. The Korean Society of Kawasaki Disease was established in 2015 and has since been conducting the triennial nationwide epidemiological survey.
Recursos textuais: teceduras
Authors: Regis Clarmi
Published: August 2023

Recursos textuais: teceduras
Unveiling immune-metabolic interaction in Atherosclerosis via Comprehensive Landscape of Hub Genes and Immune Microenvironment
Authors: Liu Fang , Li Tao , Liu Xiuwen , Qin Demeng
Published: August 2023

Objective: Atherosclerosis (AS) as a major cause of cardiovascular diseases, is considered a chronic inflammatory disease and accelerates by inflammation, lipid metabolism disorder and other mechanisms. AS pathogenesis and its relationship with immune regulation and metabolic interactions is still not fully elucidated. The purpose of this study is to delve into the correlation between mitochondrial metabolism and immunity in AS, and identify potential therapeutic targets for clinical treatment. Methods: Hub genes associated with mitochondrial metabolism and the pathogenesis of AS were identified by performing differentially expressed genes (DEGs) analysis and Weighted Gene Co-expression Network Analysis (WGCNA) based on two gene expression datasets (GSE100927 and GSE43292). And the biological processes and pathways of DEGs were determined through gene ontology (GO) and Gene Set Enrichment Analysis (GSEA) analysis. Then stepwise regression, random forest, and Lasso regression machine learning were used to evaluate the diagnostic value of hub genes. After that, the immune infiltration and single cell sequencing dataset GSE184073 were analyzed, and the immune cell composition in peripheral blood from AS patients using Mass Cytometry were detected to further consider the influence of immunoregulation. Results: Ten hub genes associated with mitochondrial metabolism and AS pathogenesis were identified, including NDUFS4, AIFM3, IDUA, TNF, CHKA, SLC11A1, SLC35C1, SLC37A2, ARSB, SLC16A5. GO and GSEA analysis showed their correlation with immunity and inflammation. Lasso regression revealed that TNF and ARSB had relatively good diagnostic performance. Further exploration was conducted on the expression of these hub genes in the immune microenvironment and their correlation with different immune factors. Mass cytometry demonstrated the influence of the vascular immune microenvironment on the pathogenesis of AS. Conclusions: Our study provides a more comprehensive understanding of the complex relationships between immune and metabolic factors and their impact on the microenvironment of AS. The identification of hub genes in AS may provide new targets for therapeutic intervention.
Further investigation on fixed point theorems via C-class functions in extended b-metric spaces
Authors: Khanpanuk Tiwabhorn , Khunpanuk Chainarong
Published: August 2023

The purpose of this research project is to develop new theories, discuss, and extend some recent common fixed point results established when the underlying ambient space is an extended b-metric space and the contraction condition involves a new class of ψ-φ-C-contraction type mappings where ψ is the altering distance function and φ is the ultra-altering distance function. The unique fixed point theorems for such mappings in the setting of ψ-φ-complete metric spaces are proven. We also prove the fixed point theorem in partially ordered metric spaces. Moreover, some examples supporting the main results are given. Our results extend and generalize corresponding results in the literature. The start of the development of the theory of fixed points is tied to the end of the 19th century. The method of successive approximations is used in order to prove the solution's existence and uniqueness at the beginning of differential and integral equations. This branch of nonlinear analysis has been developed through various classes of spaces, such as metric spaces, topological spaces, probabilistic metric spaces, fuzzy metric spaces, and others. In developing the theory of fixed points, achievements are applied in various sciences, such as optimization, economics, and approximation theory. A very important step in the development of fixed point theory was taken by A.H. Ansari through the introduction of a C-class function. Using C-class functions, we generalize some known fixed point results, and Kamran et al. introduced a new intuitive concept of distance measure to extend the notion of b-metric space by further weakening the triangle inequality.
“Adopting In-Office Needle Arthroscopy without Wrecking Your Office Flow”
Authors: McMillan Sean
Published: August 2023

In-office needle arthroscopy has seen a rebirth of interest in the past several years amongst orthopedic surgeons. While the idea of in-office intra-articular evaluation spans almost 30 years, recent advances in optics, platform portability, and disposable instrumentation has allowed for a surge of interest. While the benefits of direct visualization of intra-articular pathology, time and cost savings, and allure to patients are all attractive; introducing needle arthroscopy into a busy clinic setting without disturbing work-flow can be challenging. The purpose of this editorial is to share real life learned knowledge from my own clinical experience to help safely and effectively integrate needle arthroscopy into your practice without destroying in-office work-flow.
Intraosseous Antibiotic Infusion- An old solution for an older problem
Authors: Lowe Jermonte , Sweeney Patrick , Parekh Selene
Published: August 2023

Acute and chronic osteomyelitis are historical diseases that remain difficult to treat. Globally, Patients are impoverished and disabled due to our inability to treat this effectively. Particularly, patients with diabetes mellitus and multiple comorbidities suffer amputation and early death. Intraosseous antibiotic treatment at the infection site offers an opportunity to treat these patients efficaciously and economically.
The Modern Universal TKA: Improved Value without Compromising Quality
Authors: Law Jesua I.
Published: August 2023

In the current economic state of healthcare, efficiency and cost reduction has come into focus. Healthcare spending is accelerating faster than the growth in GDP and with a large portion of hospital costs associated with operating room expenses, inefficiencies are something that should be scrutinized closely. Several studies have demonstrated increased efficiency with an intelligent reduction in instrumentation and trays. European studies have analyzed the cost of sterilization demonstrating up to $11.52 USD per instrument sterilized. Universal tibial components have been accepted in the past and several studies have demonstrated noninferiority or even superiority over asymmetric tibial designs. Modern universal femoral designs have improved from antiquated symmetric femoral designs and recent studies have demonstrated similar femoral rollback and axial rotation compared with non-resurfaced knees along with excellent knee society scores. A modern total knee system designed around efficiency capable of maximizing patient outcomes and restoring normal knee kinematics is needed. Reductions in tray and instrument counts have saved over $250,000 annually in sterilization and storage space while improving tray utilization. Set up time is reduced, thereby enhancing room turnovers. This cost reduction comes at no detriment to the patient and with the excellent knee kinematic and outcome scores boasted by this implant, the modern universal knee system is a great value to healthcare.

Abbreviations: USD = United States Dollar; GDP = Gross Domestic Product; TKA = Total Knee Arthroplasty; CMS = Centers for Medicare and Medicaid; OR = Operating Room; PSI = Patient Specific Instrumentation
Slipped Capital Femoral Epiphysis in a 31-Year-Old Male
Authors: Fong Bronson H , Jeffers Kirk , Betech Alex
Published: August 2023

Slipped capital femoral epiphysis (SCFE) is considered a disease of adolescence where the open proximal femoral physis displaces. Factors associated with SCFE include trauma, elevated BMI, and certain endocrine disorders such as hypothyroidism, hypopituitarism, hyperparathyroidism, and hypogonadism. We are presenting a case of a 31 year old Caucasian male with a SCFE. His severe hypothyroidism and resulting hypogonadism caused the persistence of an open proximal femoral physis. He was treated with in-situ pinning of the symptomatic side as well as prophylactic pinning of the contralateral side by an orthopaedic surgeon. His endocrinopathy was identified and treated by an endocrinologist. We detail his clinical experience at our institution. SCFE is a common condition found in adolescents, but can occur in any patient that has an open physis. If an open physis is found in an adult, an endocrine disorder is usually present.
How Innovation Fueled Outpatient Shoulder Arthroplasty (SA)
Authors: Romeo Anthony
Published: August 2023

Today, with prostheses available in a variety of sizes and materials which provides the ability to match the patient’s anatomy, attention is shifting to other forms of SA innovation: advances in anesthesia and pain control, expanded eligibility criteria, improved perioperative measures, and superior surgical techniques, all of which have supported this procedure’s expansion beyond an inpatient setting.
Admitting Geriatric Hip Fracture Patients to the Orthopaedic Service Decreases Cost of Care
Authors: Zelenski Nicole A. , Brock John Logan , DeAngelis Ryan D. , Charette Ryan S. , Neuwirth Alexander L. , Mehta Samir
Published: August 2023

Introduction

Hip fractures are common and costly, costing $12 billion annually in the US. A large portion of the cost of care is related to inpatient care, which is highly variable. There is a lack of strong evidence regarding whether medicine or orthopaedics should serve as the primary admitting and managing service in the care of hip fracture patients with neither having improved outcomes. The purpose of this study is to compare the cost of care between patients who were admitted to orthopaedic vs. non-orthopaedic services after geriatric hip fractures.

Methods

A retrospective chart review was conducted of patients over the age of 55 with hip fractures undergoing operative treatment at a Level 1 trauma center between 2010-2013. We examined demographic information, admitting service (orthopaedic vs. non-orthopaedic), length of stay, ASA score as well as reimbursement and cost information. Statistical analysis was performed to evaluate what factors most influence cost of care.

Results

A total of 326 patients with hip fractures were included in the analysis. After controlling for age, sex, BMI, and ASA score, admission to the orthopaedic service was associated with $3,172 lower total costs than admission to a non-orthopaedic service (p=0.0001). Patients admitted to the orthopaedic service were discharged an average of 2.6 days earlier than patients on the non-orthopaedic service (p<0.0001). There was no difference in 30-day readmission or 90-day mortality between the two groups.

Discussion

Hip fracture patients admitted to the orthopaedic service are discharged sooner than patients admitted to a non-orthopaedic service, even when controlling for ASA score. Nationally, this implies substantial potential cost savings from admitting patients to orthopaedic rather than non-orthopaedic services. Systems should develop clear guidelines on when it is appropriate to admit hip fracture patients to non-orthopaedic services, and the orthopaedic service should be the default admitting service.
Opinion: A case for Orthopedic Orphans
Authors: Kay David
Published: August 2023

Orthopedists are tinkerers and makers. In our current system, there are few outlets for this type of innovation to be broadly distributed unless a “company” sells the product. This opinion offers another solution, where instruments (orphans) can be created and distributed as open source using CAD and 3D printing.
Trends in Reverse Total Shoulder Arthroplasty: How the Early Trends in New Innovation Provide Experience in Utilization of Later Designs
Authors: Navarro Ronald A. , Mellano Chris R. , Sievers Dennis A. , Harrast John J. , Carpenter James E. , Jackson Kent R. , Dillon Mark T.
Published: August 2023

Background

Recent literature has described an increase in overall rates of shoulder arthroplasty procedures being performed. To date few reports have characterized the yearly trended earliest incidence of introduction of the then innovative reverse total shoulder arthroplasty (RTSA) since FDA approval in 2003. This study aimed to describe the earliest surgical trends in RTSA use performed in the United States over time. We believe this knowledge will help show how early trends in new innovations provide experience to understand later iterative innovation in the same device.

Methods

Two complementary datasets that recorded RTSA use discretely at the advent of use in America were reviewed to compare the rates of RTSA being performed on national and regional levels over time. The American Board of Orthopaedic Surgery (ABOS) national database was reviewed, to identify all shoulder arthroplasty cases reported by Part II candidates from 2005-2010. RTSA, total shoulder arthroplasty (TSA), and shoulder hemiarthroplasty cases were each identified separately. Additionally, a regional integrated healthcare system implant registry was reviewed to identify all RTSA, TSA, and shoulder hemiarthroplasty cases performed from 2005-2010. Surgical trends in RTSA rates from both datasets were calculated and compared.

Results

From 2005-2010 the national ABOS database reported 2,674 shoulder arthroplasty cases, of which 425 were RTSA. In 2005, 19 RTSA cases were reported to the ABOS and constituted 5.2% of all shoulder arthroplasty cases reported. In 2010, 108 RTSA cases were reported and constituted 24.5% of all shoulder arthroplasty cases, an increase of 369%. Meanwhile the regional integrated healthcare system implant registry from 2005-2010 reported 1519 shoulder arthroplasty cases of which 174 were RTSA. In 2005, 8 RTSA cases were reported through this registry and constituted 4.1% of all shoulder arthroplasty cases. In 2010, 49 RTSA cases were performed and constituted 14.9% of all shoulder arthroplasty cases, an increase of 173%.

Conclusion

Rates of RTSA being performed have increased dramatically since FDA approval. Both regional and national rates showed this increase, suggesting a lack of regional bias. The rise of RTSA use has continued since these early documented rates with newer literature supporting increases in indications and volumes. This report serves as a retrospective comparison of the earliest documented RTSA use. The use rates early in the experience of the innovative idea of RTSA may be instructive and educational to surgeons in this time of expanding indications for RTSA and with utilization of newer RTSA designs.

Level of Evidence

Level III Retrospective Comparative Study
How has Return on Investment of a Career in Orthopaedic Surgery Changed Over Time?
Authors: Mody Kush S. , Mikhail Christopher , Barbera Joseph , Cho Samuel K. , Parekh Selene G.
Published: August 2023

INTRODUCTION

The rising cost of medical education, coupled with a lack of personal finance education, can have detrimental effects on both the personal and professional well-being young orthopaedic surgeons. This study utilizes a career in orthopaedic surgery as a case study to 1) elucidate changes in the return on investment (ROI) of a career in medicine 2) discuss the personal and professional implications of these changes for young surgeons, and 3) advocate for widespread personal finance education for trainees.

METHODS

Financial analysis principles, including net present value (NPV), internal rate of return (IRR), and multiple on invested capital (MOIC), were used to examine ROI of a career in orthopaedics in 1989, 1999, 2009, and 2019. Data was collected on undergraduate and medical school tuition, resident salary, and orthopaedic surgeon compensation from publicly available databases. Student loan payments were excluded from this study. All values were adjusted for inflation to $US Dollars in 2020 for comparison.

RESULTS

From 1989 to 2019, there was no change in NPV, IRR decreased from 25% to 15%, and MOIC decreased from 21.5x to 8.0x. During this time, there was also a 172% inflation-adjusted increase in the cost of medical education. This resulted in a 3-year change in the orthopaedic surgery break-even point from the fourth year in residency to the second year in practice as an attending surgeon.

DISCUSSION

Since 1989, ROI has decreased substantially, and the break-even point has been delayed by 3 years. By understanding how their financial situation differs from those who graduated decades ago, young orthopaedic surgeons can better inform themselves and plan accordingly. Leaders in the field and training programs should consider offering personal finance education that is uniquely tailored to young orthopaedic surgeons and trainees today.
Fairness in AI: How Can We Avoid Bias and Disparities in Orthopedic Applications of Artificial Intelligence?
Authors: Surmacz Karl , Kamath Atul F , Van Andel Dave
Published: August 2023

Recent advances in artificial intelligence have the potential to transform the field of orthopedics. As well as the opportunities there are numerous challenges associated with applying AI to clinical decision-making, one such example being algorithmic fairness. In this article we introduce the concepts of bias and fairness in machine learning from an orthopedics perspective, covering concepts, examples, possible approaches and implications on the community. We hope that by working to embed these concepts and associated best practice into health data-product development workflows, we can help to promote fair and effective use of these powerful tools for all patients.
The Ethical Implications of Reusing External Fixation Systems: A Used Car or A Plastic Water Bottle?
Authors: Friedman Lisa G. M. , Suk Michael
Published: August 2023

The reuse of external fixation systems raise several important ethical considerations. Reusing external fixators can decrease costs, but questions emerge about who owns the implant, who will benefit from the savings, and the need to disclose the use of reprocessed parts. In addition, there are concerns relating to infection, as well as humanitarian and environmental considerations that must be weighed when deciding whether to implement a reprocessing program for external fixators.