bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Pengaruh Pola Pemuatan Top Loading dan Bottom Loading Ore Terhadap Produktivitas Penambangan pada PT. Bumi Karya Makmur (Site Job PT. Ceria Nugraha Indotama) Kecamatan Wolo Kabupaten Kolaka Sulawesi Tenggara
Authors: Bahar Wahyuddin , Nurfasiha Nurfasiha , Kumalasari Rizki
Published: November 2024

PT. Ceria Nugraha Indotama (CNI) adalah perusahaan nasional yang mengoperasikan tambang Nikel yang berlokasi di Kecamatan Wolo, Kabupaten Kolaka, Provinsi Sulawesi Tenggara. PT. Ceria Nugraha Indotama mendapatkan area pertambangan di Blok Lapao-pao seluas 6.785 hektar melalui pemenangan atas lelang yang diselenggarakan oleh Pemerintah Indonesia. Tujuan dari penelitian ini untuk mengetahui tingkat efisiensi kerja pada pola pemuatan Top loading dan Bottom Loading dan mengetahui jumlah produksi yang di peroleh serta menganalisis perbandingan produktivitas alat excavator dengan menggunakan pola pemuatan Top Loading dan Bottom Loading. Berdasarkan hasil penelitian yang telah dilakukan mengenai pengaruh pola pemuatan Top Loading dan Bottom Loading pada alat Excavator Caterpillar PC345, maka dapat ditarik kesimpulan sebagai berikut. Pola pemuatan yang diterapkan dilapangan oleh PT. Ceria Nugraha Indotama yaitu pola muat Top Loading dan Bottom Loading. Berdasarkan hasil pengolahan data tingkat efisiensi kerja pola pemuatan Top Loading lebih tinggi dengan efisiensi rata-rata 81% sedangkat pada pola pemuatan Bottom Loading dengan efisiensi rata-rata 80%. Berdasarkan hasil pengolahan data, perbandingan produksi Excavator Caterpillar PC345 dengan pola muat Top Loading yaitu 28.455 Ton/minggu dengan produksi rata-rata 4.065 Ton/hari, Sedangkan kemampuan produksi Bottom Loading yaitu 21.890 Ton/minggu dengan produksi rata-rata 3.127 Ton/hari, dengan selisih 938 Ton/hari atau sebesar 23%.
Analisis Kestabilan Lereng Pit Penambangan Pit Ulusawa PT. Gerbang Multi Sejahtera Kecamatan Laonti Kabupaten Konawe Selatan Provinsi Sulawesi Tenggara
Authors: Acica Asri , Salu Sahrul Poalahi , Yatjong Isramyano
Published: November 2024

Kegiatan penggalian dalam proses penambangan dilakukan untuk mendapatkan material bernilai ekonomis yang terdapat di bawah permukaan bumi. Proses ini berdampak terhadap perubahan geometri lereng alami yang akan mempengaruhi distribusi tegangan pada lereng dan dapat mengakibatkan keruntuhan lereng. PT. Gerbang Multi Sejahtera (GMS) sebagai salah satu perusahaan di bidang industri pertambangan nikel yang beroperasi di Kecamatan Laonti, Kabupaten Konawe Selatan yang dalam menjalankan aktivitas penambangannya menerapkan sistem tambang terbuka dengan metode open pit sehingga membentuk cekungan dengan dimensi geometri lereng tertentu. Dengan kondisi tersebut maka harus dilakukan analisis kestabilan lereng untuk mencegah terjadinya keruntuhan lereng. Penelitian ini dilakukan di Pit Ulusawa menggunakan data geometri lereng dan data hasil pengujian laboratorium yang telah ada berupa data kohesi, sudut geser dalam dan bobot isi tanah. Tujuan dari penelitian ini adalah untuk mengetahui nilai FK lereng pada Pit Ulusawa di PT. GMS dengan melakukan analisis kestabilan lereng menggunakan metode Bishop dengan permodelan numerik pada Software Slide V.6.0 dan analisis manual. Berdasarkan hasil analisis yang dilakukan, lereng Pit Ulusawa PT. GMS termasuk dalam kondisi stabil (FK>1,3) dengan nilai FK lereng permodelan Software Slide V.6.0 untuk lereng tungggal dengan material limonit sebesar 3,969 dan saprolit sebesar 2.922 sedangkan FK pada perhitungan manual menggunakan Ms. Excel untuk lereng tunggal dengan material limonit sebesar 6.582 dan saprolit sebesar 4.169. Untuk FK lereng overall menggunakan permodelan Software Slide V.6.0 sebesar 1.870.
Perencanaan Normalisasi Sungai Untuk Penanggulangan Banjir di Daerah Pertambangan
Authors: Gunawan Risal , Jalil Abdul , Prianata Yogi La Ode
Published: November 2024

Aktivitas penambangan di dekat sungai dapat mengakibatkan sendimentasi yang dapat mengakibatkan berkurangnya kemampuan daya tampung sungai dalam menampung air sehingga terjadinya peluapan atau banjir. Banjir merupakan suatu peristiwa dimana level air sungai meluap dan menggenangi daerah di sekitarnya yang dapat menyebabkan kematian, kerugian harta benda, dan kerugian ekonomi karena terganggunya kegiatan ekonomi, untuk itu penulis melakukan  studi literature review  dengan tujuan  perencanaan normalisasi sungai untuk penanggulangan banjir di daerah pertambangan, berdasarkan studi hal yang perlu dipersiapakan: Data curah hujan minimal 10 tahun terakhir merupakan data yang penting  pendukung untuk meprediksi curah hujan di daerah penelitian, analisis data hidrologi seperi analisis frekuensi curah hujan rencana dan analisis debit sesuai rencana, Analisis air Limpasan, pengukuran penampang sungai , perencanaan atau desain ulang saluran sungai, Analisis profil aliran yang sudah di normalisasi menggunakan dengan software pendukung yang bisa di gunakan yakni program HEC-RAS.
Studi Kesiapan Sekolah Mengimplementasikan Kurikulum Merdeka di Kabupaten Sumba Barat Daya
Authors: Suluh Melkianus , Lede Yulita Adelfin , Bitu Yuliana Sesi
Published: November 2024

This research aims to find out the knowledge and understanding of teachers and principals about the independent curriculum and to find out the readiness of schools to implement the independent curriculum. This research was conducted in Tambolaka City District and Loura District, Southwest Sumba Regency-East Nusa Tenggara. This study is evaluation survey research with a qualitative descriptive approach. The subjects of this study are 24 high school Physics teachers and junior high school science teachers and 12 school principals. Data collection uses interview instruments and questionnaire instruments. The distribution of the questionnaire was carried out using a google form. The analysis is carried out by reducing data, presenting data, and drawing conclusions. The results of the study show that (1) Teachers and Principals who are the subjects of the study have not understood well the concept and strategy of implementing the independent curriculum, (2) Schools are ready to implement the independent curriculum as a form of support for the government's efforts to improve the quality of education, (3) Teachers and Principals of the research subjects have a positive view of the implementation of the independent curriculum on average
Strategi Guru dalam Pemanfaatan Media Bahan Alam dan Lingkungan Sekitar untuk Meningkatkan Kreativitas Anak Usia Dini di PAUD Melati Duko Rubaru Sumenep
Authors: Ulfah Ulfah
Published: November 2024

This research discusses the development of creativity in early childhood through the use of natural materials and the surrounding environment in pre-school education. A supportive environment, including the role of professional teachers, is considered crucial for facilitating children's creativity. Although natural materials offer creative opportunities, challenges such as material durability and management by teachers still need to be overcome. This research focuses on teachers' strategies for utilizing natural materials and the surrounding environment and exploring their advantages and disadvantages. The method in this research uses a qualitative descriptive approach, this research was conducted at PAUD Melati Duko Rubaru Sumenep using interviews and observation as data collection techniques. Data analysis was carried out using qualitative descriptive analysis techniques on the results of interviews and observations. The research results show that the use of natural media and the surrounding environment has made a positive contribution in stimulating children's creativity, although challenges remain. Some effective teacher strategies include using banana stems and leaves for artistic activities as well as cardboard media for children's independent creations. In conclusion, this approach provides important insights into the importance of using natural media in pre-school education and provides recommendations for further development in the context of early childhood education
Demographics and Outcomes of Testicular Tumors in Patients Treated at King Faisal Specialist Hospital and Research Centre, Riyadh
Authors: Alkhateeb Sultan Saud , Alrumayyan Majed , Alotaibi Mohammed Faihan
Published: November 2024

Testicular cancer is a relatively rare but significant malignancy, primarily affecting males between the ages of 15 and 35. The incidence and epidemiological patterns of testicular cancer vary across different geographic regions. This study aims to describe the demographics and outcomes of testicular tumors in patients treated in a tertiary setting at King Faisal Specialist Hospital and Research Centre in Riyadh. This retrospective cohort study was conducted at King Faisal Specialist Hospital and Research Centre (KFSHRC), focusing on patients across various regions in the kingdom from 2000 to 2017. The research offers a comprehensive retrospective analysis. The records of 125 males diagnosed and treated with testicular cancers with an age bracket of 14-35 years were examined. It was observed that males aged 26-35 showed the highest rate of incidence of testicular cancer. The primary differences between the progression of seminomas and nonseminomas are explored, with the latter comprising diverse subtypes such as yolk sac tumors, teratomas, embryonal carcinomas, and choriocarcinomas. This research studied patient demographics, clinical presentations, histopathological patterns, treatment modalities, and associated complications. Apart from stage 3 cases, the present research found consistency in survival outcomes, recurrence rates, and risk variables across locations. This retrospective cohort study challenges long-held beliefs and offers new insight into the treatment and prognosis of patients with testicular cancer at the KFSHRC. This study is significant because it has the potential to influence future methods of treating testicular cancer and advance knowledge of the subtleties and regional variations of the illness, which is beneficial for both patients and healthcare professionals.
Enhanced Antibacterial Efficacy of Cymbopogon winterianus Jowitt in Combination with Carvacrol
Authors: Ak-sakallı Ezgi , İlktaç Mehmet , Atlı Beste , Öztinen Nesrin , Koşar Müberra , Demirci Fatih
Published: November 2024

The continuous increase of antibiotic resistance and the lag in development of novel antibiotics are two important challenges in treatment of infectious diseases. Essential oils (EOs) and their combinations are promising alternatives for treatment of bacterial infections. Cymbopogon winterianus Jowitt EO, recognized by the European Medicines Agency for its sleep-enhancing and anxiety-relieving properties, also possesses sedative qualities, as noted in the German Commission E monograph, and aids in treating sleep disorders. The aim of the study was to investigate antibacterial activities of the C.winterianus EO and carvacrol combination. Commercial C. winterianus EO and carvacrol were tested for antibacterial activity against the American Type Culture Collection quality control strains Staphylococcus aureus, Enterococcus faecalis, Escherichia coli and Klebsiella pneumoniae using the broth microdilution method. Ciprofloxacin served as the standard antimicrobial agent. Checkerboard assay was used to evaluate the combined effects of C. winterianus EO and carvacrol.
The results showed that C. winterianus EO exhibited moderate antibacterial activity against both Gram positive and Gram negative bacteria. The interaction between C. winterianus EO and carvacrol was additive against all tested bacteria. The minimum inhibitory concentration of carvacrol decreased by 2- to 8-fold when the carvacrol combined with C. winterianus EO, and carvacrol also enhanced the antibacterial activity of EO by 2- to 16-fold.
Antibacterial activity of naltrexone and its combination with ciprofloxacin against Gram negative and Gram positive bacteria
Authors: Özbil Ertuğrul , Öğmen Sultan , İlktaç Mehmet
Published: November 2024

Naltrexone, an opioid receptor antagonist, is commonly used in the treatment of alcoholism. Studies about the antibacterial activity of naltrexone are limited. In our study, we aimed to evaluate the antibacterial and synergistic activities of naltrexone against Staphylococcus aureus ATCC 25923, Enterococcus faecalis ATCC 29212, Escherichia coli ATCC 25922 and Klebsiella pneumoniae ATCC 700603. The results showed promising antibacterial activity against all tested pathogenic bacteria. Additionally, checkerboard assays revealed additive activity against S. aureus when combined with ciprofloxacin. Collectively, the data from our study suggest that naltrexone can further be used as a potential antibacterial source alone or in combination with other antibiotics in the treatment of bacterial infections.
Dahûrîna Wergera Kurdî ya Heft Haîkûyên Jack Kerouac li dor Modela Analîza Werger-Navend a Christiane Nordê
Authors: Çeliktaş Sami , Ertekin M. Zahir
Published: November 2024

Cureya haîkûyê nerîteke helbestê ya edebiyata Japonî ye û ji hêla teşe û naverokê ve xwedî taybetiyên xwemalî ye. Nimûneyên vê cureya helbestê ji sedsala 19an û pê de li nav edebiyatên cîhanê jî diyar bû. Nimûneyên wergerê yên haîkûyan, ji hêla hejmarê ve kêm be jî, li wan salên dawî di edebiyata Kurdî de jî xuya dibin. Haîkûyên Amerîkî ji hêla teşe û naverokê ve ji nerîta haîkûya Japonî cuda dibin. Di vê pêwendiyê de taybetî û şêwaza wergerên Kurdî yên haîkûyan û têkiliya wan a bi haîkûyên resen, dibe mijareke lêkolînê. Di vê xebatê de, li dor modela Christiane Nordê ya bi navê analîza tekstê ya werger-navend me wergerên Kurdî yên heft haîkûyên Jack Kerouac nirxandin. Me bala xwe da ser tercîh û pêşekiyên wergêr, da ku em karibin rêbaza wergêr şirove bikin. Di çarçoveya modela Nordê de jî me hokarên navmetnî û dermetnî li ber çav girtin, da ku em fonksiyon û hevtayiya edebî ya teksta jêder û teksta armanc bi şiklekî berawirdî binirxînin. Bi dahûrandina wan wergeran, me armanc kir ku em têkiliya haîkûyên resen û yên wergerandî ronî bikin, di çarçoveya şêwaz û cureya haîkûyê de hevtayiya edebî ya haîkûyên jêder û yên armanc destnîşan bikin û wergera wan haîkûyan rexne bikin.
Analysis of factors affecting the incidence of Pneumonia, length of stay in intensive care unit (ICU), and mortality in traumatic cervical spinal cord injury (tCSCI) patients after surgery
Authors: Wardhana Wahyu Wiswa , Semedi Bambang Pujo , Santosa Dhania Anindita , Hamzah Hamzah , Sumartono W Christrijogo
Published: November 2024

Spinal cord injury is a condition that has a catastrophic impact on the clinical, social, and economic well-being. It has a poor prognosis as it leads to neurologic impairments, as well as disruption of the diaphragmatic muscles. This condition is one of the risk factors associated with increased morbidity and mortality. All ICU patients who met the inclusion and exclusion criteria at Dr. Soetomo Hospital between January 2023 and January 2024 had their Electronic Medical Records (EMR) data used in this retrospective analytical study. The 38 patients in the sample were collected. All of the samples were male, and their average age was 45 years. Of these, 11 patients (29%), had 30-day mortality, while 21 patients (55%), had pneumonia. The majority of patients (n = 16; 42%) were classified as AIS A, and the lower cervical area was the most often affected lesion site (16; 42%). The most frequent mode of injury was falling from a height including 24 patients (63%),. Fifteen patients (39%) underwent tracheotomies. Vasopressor use was found to have an impact on the incidence of pneumonia (p=0.003; OR 13.57). Tracheostomy was the risk factor that affected the duration of ICU hospitalization (p<0.001) and the incidence of 30-day mortality (p=0.012; OR 7.61). A factor that must be taken into account while assessing the prevalence of pneumonia is the use of vasopressors. In other hand, tracheostomy is one factor that affects 30-day mortality and length of stay in the intensive care unit.
SEMIOTIKA DALAM NOVEL I AM SARAHZA KARYA HANUM RAIS DAN RANGGA ALMAHENDRA SERTA IMPLIKASINYA BAGI PEMBELAJARAN BAHASA DAN SASTRA INDONESIA DI SMA
Authors: Salsabila Afifa , Mahajani Tri , Talitha Stella , Chodijah Siti
Published: November 2024

ABSTRAK: Tujuan penelitian ini adalah untuk mendeskripsikan aspek tanda yang terdapat pada novel I Am Sarahza karya Hanum Rais dan Rangga Almahendra serta implikasinya bagi pembelajaran Bahasa dan Sastra Indonesia di SMA. Wujud data pada peneitian ini adalah berupa kutipan yang mengandung aspek tanda pada novel I Am Sarahza. Berdasarkan wujud data dan sumber data, maka data yang berupa kutipan diidentifikasi berdasarkan aspek tanda yang terkandung dalam novel. Penelitian ini dapat diimplikasikan pada siswa kelas XII, dan dapat diterapkan pada materi unsur intrinsik dan ektrinsik pada novel. Penelitian ini dapat dimanfaatkan oleh pendidik sebagai pengajaran bahasa Indonesia dan dapat memberikan ilmu pendidikan sastra serta bagi siswa dapat mengambil segi positif dari novel I Am Sarahza.Kata Kunci: Karya Sastra, Novel, Aspek Semiotika, Implikasi pembelajaran bahasa. ABSTRACT: The purpose of this study is to describe the aspects of signs contained in the novel I Am Sarahza by Hanum Rais and Rangga Almahendra and their implications for learning Indonesian language and literature in high school. The data source used in this research is the novel I Am Sarahza by Hanum Rais and Rangga Almahendra. The form of data in this research is in the form of quotations containing aspects of signs in the novel I Am Sarahza. This research can be implicated in class XII students, and can be applied to the intrinsic and extrinsic elements of the novel. This research can be used by educators as an Indonesian language teaching and can provide literary education and for students to take the positive aspects of the novel I Am Sarahza. Keywords: Literary Works, Novels, Semiotic Aspects, Implications of language learning.
Development of Battery-Independent Illumination Drones Integrated into Tethered UAVs for Extended Operations
Authors: Ünler Tarık
Published: November 2024

This study presents the design of an unmanned aerial vehicle (UAV) specifically developed for extended illumination in surveillance, search and rescue (SAR) operations, security enforcement, border surveillance, and other applications requiring lighting, particularly in disaster areas. Traditional battery-powered UAVs have limited operational time; therefore, a tethered drone design was implemented in this study to overcome flight duration constraints. The direct current (DC) energy required for the tethered drone is supplied by a Gold Series switch-mode power supply (SMPS) mounted on the drone. The alternating current (AC) energy needed for the SMPS is transmitted through a cable. Additionally, the light-emitting diode (LED) projector, operating on AC 220 volts, is powered by the same cable that supplies the drone, eliminating the need for an additional DC converter. This design choice reduces weight and ensures an optimized configuration. The projector is mounted on servos with dual-axis capability, allowing both horizontal and vertical movement to precisely illuminate the target area. Although studies on tethered and illumination drones exist in the literature, this work combines two distinct drone systems to create a more efficient UAV design. In the design process, considerations were made for various environmental conditions, particularly wind. Consequently, the thrust-to-weight (T/W) ratio was determined to be 1.54. For cable cross section, a 1.5% voltage drop was accounted for, yielding a required cross section of 1.16mm². However, to ensure safety and reliability, a cable with a cross section of 1.5mm² was selected. This proposed model, distinct from other studies in the literature, offers a practical design for field applications, particularly for night SAR operations in disaster zones such as earthquake sites, due to its point-focus illumination capability and extended flight duration.
Farmacoterapéutica
Authors: Llop Rius Roser , Bosch Ferrer Montserrat
Published: November 2024

Introducción
Este año hemos planteado una selección para remarcar la importancia de los riesgos asociados al uso de medicamentos, la necesidad de detectarlos y de plantear acciones de minimización. No hay duda de que cualquier fármaco con una acción terapéutica va acompañado de cierta acción tóxica. En el momento de su autorización, la información disponible sobre la seguridad de los medicamentos es limitada y solo la experiencia de uso permite aumentar el conocimiento sobre la toxicidad potencial. En esta selección se confirman riesgos asociados a fármacos conocidos y muy utilizados como los opiáceos, los gabapentinoides, las fluoroquinolonas o las estatinas. Resulta fundamental tener en cuenta varios aspectos: por un lado, es necesario evaluar los efectos adversos desconocidos y/o graves, que pueden modificar en cualquier momento la relación beneficio/riesgo de un nuevo producto. Por otro lado, es necesario plantear estrategias de farmacovigilancia que permitan identificar los grupos de población más susceptibles y que informen de manera adecuada a los profesionales sanitarios implicados directamente en el tratamiento de los pacientes. Por último, de nuevo conviene recordar que una prescripción razonada, reflexiva y prudente contribuye también a garantizar un uso más seguro de los medicamentos. En este sentido, la semaglutida puede ser un buen ejemplo de que solo el equilibrio entre los intereses comerciales y de salud del paciente puede garantizar un uso que se asocie a los máximos beneficios y los mínimos riesgos.

A continuación, se comentan algunos artículos que, por su actualidad o relevancia, merecen ser destacados.
Ampliación de ambientes libres de humo. Una nueva oportunidad
Authors: Barchilón Cohen Vidal Samuel
Published: November 2024

El consumo de tabaco es una de las causas evitables de muerte prematura más importantes en todo del mundo. El número de muertes atribuibles al tabaco en España continúa siendo muy elevado, con cerca de 63.000 muertes anuales, el 21% de ellas en menores de 65 años, según los últimos datos de la Encuesta Nacional de Salud de España.

En 1999, el Banco Mundial realizó una exhaustiva revisión sobre las medidas de intervención más coste-efectivas para reducir el impacto del tabaquismo en la que indicaba la necesidad de aplicar medidas de políticas sanitarias por parte de los respectivos gobiernos. En 2003, la Organización Mundial de la Salud (OMS) impulsó políticas preventivas para el control del tabaquismo mediante el Convenio Marco de la OMS para el Control del Tabaco. Este convenio se ha convertido en uno de los tratados más ampliamente adoptados en la historia de las Naciones Unidas.
El momento de pedir una analítica. El preanálisis
Authors: Coscollar Santaliestra Carlos
Published: November 2024

Puntos clave
Las circunstancias laborales, profesionales y sociales, y la cultura sanitaria, entre otros condicionantes, no suelen alinearse de modo favorable para propiciar una adecuada y prudente gestión de las pruebas diagnósticas.
Solicitar un análisis es una decisión compleja y difícil, especialmente si se contempla desde el compromiso con el paciente de ofrecer atención de calidad, sin comprometer su seguridad.
La mayor parte de los errores de laboratorio (46-71%) se localizan en la fase preanalítica. Suelen estar asociados a la recogida, la manipulación/el procesamiento y el transporte de la muestra.
La variabilidad preanalítica se refiere a aquellas circunstancias que pueden afectar al resultado y están relacionadas con el período previo a la llegada de la muestra al laboratorio.
La indicación de una determinada prueba viene condicionada por la probabilidad de que su resultado pueda influir en resultados en salud en el paciente. Si esa probabilidad anticipada es baja, es muy probable que la prueba pueda, o deba, ser evitada.
Estandarizar todo el procedimiento es la mejor manera de disminuir la variabilidad preanalítica evitable.
Las guías internacionales no han especificado con precisión y unanimidad los requisitos de ayuno. Sin embargo, conviene respetar unos requerimientos mínimos.
Podemos hablar de adecuación en la prueba solicitada, cuando el resultado responde a una pregunta clínica previa, el beneficio excede al daño y puede hacerse a un coste y riesgo razonables.
A raíz de una faríngoamigdalitis: sífilis secundaria
Authors: Rascón Roig Noelia , Gauchía Mulet Claudia , Garrido Calvo Laura
Published: November 2024

Puntos clave
La sífilis es una infección sistémica producida por una espiroqueta, Treponema pallidum.
La vía sexual es la forma de transmisión más frecuente.
Es una enfermedad de declaración obligatoria.
Existen diferentes fases en función de la cronología. Sífilis precoz <1 año, tardía >1 año.
Se debe pensar en sífilis ante una afectación cutánea como un exantema maculopapuloso generalizado y también ante una afectación mucosa como una faringoamigdalitis que no mejora con tratamiento habitual.
Ante la sospecha diagnóstica se debe interrogar al paciente por posibles relaciones sexuales de riesgo.
En los pacientes diagnosticados por sífilis se deberá descartar otras infecciones de transmisión sexual (ITS) concomitantes y hacer un estudio de contactos.
El tratamiento de elección es la penicilina. En alérgicos a esta, se debe emplear doxiciclina.
Síndrome constitucional y debilidad
Authors: Ramis Fernandez Maria , Hidalgo Muñoz Melanie , Ortuño Daniel Marina
Published: November 2024

Resumen
Paciente, hombre de 76 años de edad, con antecedentes de hipertensión y diabetes que inicia un síndrome constitucional tras la intensificación del tratamiento hipoglucemiante con elevación de transaminasas. Se suspende el tratamiento con vildagliptina ante la sospecha de hepatitis como efecto secundario. Se realiza un control evolutivo, iniciando clínica de debilidad muscular proximal y síndrome constitucional, así como elevación de transaminasas hepáticas a pesar de la suspensión del tratamiento. Se realiza un estudio mediante electromiograma y anticuerpos anti-HMG-CR que confirman el diagnóstico.
Síndrome de Weil, un gran desconocido
Authors: del Carmen Pérez Hernández Evelin , Miguens Uriel Alejandro , Deniz Calderín Eulogio
Published: November 2024

Puntos clave
La leptospirosis es la zoonosis más extendida en el mundo, siendo los humanos huéspedes accidentales.
La enfermedad de Weil ocurre en, aproximadamente, el 5 al 10% de los casos de leptospirosis y es una enfermedad rápidamente progresiva asociada con tasas de mortalidad del 5 al 15%.
Debemos pensar en el síndrome de Weil en un paciente con afectación reno-pulmonar, fiebre, alteración hematológica y que ha estado en contacto con aguas estancadas o roedores.
La hemorragia alveolar es una complicación grave de la enfermedad de Weil, se observa en menos del 5% de los pacientes y tiene mal pronóstico.
El diagnóstico se realiza a través de muestras sanguíneas mediante serologías, cultivos y PCR.
El tratamiento consiste en la administración de antibióticos, debiendo individualizar, en cada caso, el uso de corticosteroides.
Un caso de artralgias, fiebre y diarrea. ¿Cómo hacer el diagnóstico sin perderme en el intento?
Authors: Rifà Terricabras Sílvia , Font Roura Pilar
Published: November 2024

Puntos clave
La enfermedad de Whipple es una enfermedad infecciosa rara. La bacteria que la provoca es el Tropheryma whipplei.
Entre sus manifestaciones clínicas más frecuentes se incluyen artralgias, pérdida de peso, diarrea, dolor abdominal y fiebre.
El retraso medio del diagnóstico es de 6 años.
El diagnóstico se realiza con biopsia duodenal con un test de PAS y PCR positivo.
El tratamiento es con ceftriaxona 2 g/día intravenosa (IV) durante 2 semanas y cotrimoxazol 160/800 mg/12 h durante 1 año.
Explorando a associação entre a Síndrome de Guillain-Barré e a infecção por Dengue: uma revisão integrativa
Authors: Reinert Bárbara , Reinert Bianca Iara , Cezario Daniela Gomes da Rocha , Ferreira Larissa Bahls , Angioletti Tânia , Kessler Rubia Mara Gicchini , Geretto Daiana Aparecida Rech , Kerkoski Edilaine , Chesani Fabíola Hermes
Published: November 2024

Introdução: A Síndrome de Guillain-Barré pode estar relacionada à dengue, transmitida pelo mosquito Aedes aegypti, por meio de mecanismos imunopatológicos complexos, como o mimetismo molecular. Objetivo: Identificar a produção do conhecimento científico sobre as repercussões da dengue, uma doença transmitida por mosquitos Aedes, na síndrome de Guillain-Barré, uma condição neurológica rara que causa fraqueza muscular. Método: Trata-se de uma revisão integrativa realizada em seis fases. A pesquisa de artigos foi conduzida com base em descritores específicos, aplicação de filtros e critérios de inclusão e exclusão previamente estabelecidos. Resultados: Após a busca nas bases de dados foi obtido um total de 3.229 artigos e ao final da aplicação dos filtros e critérios de inclusão e exclusão, somente dois artigos foram selecionados para entrar na pesquisa. Conclusão: Os estudos mostraram que o mimetismo molecular emerge como um possível mecanismo subjacente à associação entre a infecção viral e as complicações neurológicas. É crucial investir em mais estudos clínicos para aprofundar o entendimento sobre o mecanismo de relação entre a dengue e a Síndrome de Guillain-Barré.
Incidência de Acidente Vascular Cerebral na população adulta do Estado do Piauí: um estudo ecológico
Authors: Costa Maria Rafaela Barros , Costa Gabriela Barros , Silva Államy Danilo Moura e , Silva Filipe Melo da , Costa Domingos Robson Silva , Moita Carolina de Paula , Santos Paulina de Fátima Gomes dos
Published: November 2024

Objetivo: Analisar a incidência de Acidente Vascular Cerebral na população adulta do Estado do Piauí entre os anos 2013 a 2023. Metodologia: Estudo ecológico de série temporal, utilizando dados do Sistema de Informações Hospitalares (DATASUS) referentes a todas as internações da população adulta do Estado do Piauí entre 20 e 59 anos.  Investigou-se as seguintes variáveis: faixa etária; sexo; cor; ano do atendimento; município; macrorregiões de saúde e internações por AVC. Resultados: Houve uma redução nas internações por AVC ao longo do período, com o maior número de internações em 2017 e uma queda acentuada em 2020, possivelmente devido à pandemia de COVID-19. A maior prevalência foi em homens e na faixa etária de 50 a 59 anos, com predomínio de casos na macrorregião do Meio Norte. Conclusão: Apesar da tendência de redução nas internações, o AVC permanece uma importante questão de saúde pública no Piauí, demandando estratégias contínuas de prevenção e manejo, além de melhorias nas práticas de cuidado.
O IMPACTO DO PERÍODO GESTACIONAL E PUERPERAL NA SAÚDE MENTAL DE MULHERES NO BRASIL
Authors: Costa Laura Tavares da , Santos Mariana Fernandes Ramos dos
Published: November 2024

A gravidez e o pós-parto representam uma fase caracterizada por significativas transformações, envolvendo não apenas alterações fisiológicas e hormonais que impactam diretamente a saúde mental de mulheres, mas também demandas emocionais intensas e exclusivas que não estavam presentes em outros momentos da vida. Este estudo visou explorar e discutir sobre defrontação na psique feminina em período de gravidez e no pós-parto no Brasil, sendo um tema de relevância para a saúde pública devido aos impactos tanto na saúde da mulher quanto no desenvolvimento futuro da criança. Portanto, o trabalho visou compreender de forma abrangente e holística os fatores que contribuem para o impacto do período gestacional e puerperal na saúde mental das mulheres no Brasil, buscando despertar mais interesses pelo tema, conscientização, detecção precoce e intervenção a fim de promover o bem-estar emocional e psicológico das mulheres durante essa fase crucial de suas vidas. Conclui-se que, além do suporte social e psicoeducação com fins incentivantes, é essencial a promoção de políticas públicas que garantam suporte psicológico às gestantes e puérperas, contribuindo para a saúde mental e o desenvolvimento saudável da criança.
ENTRE A TRANSGRESSÃO E A PROTEÇÃO: UMA ANÁLISE DAS EXPERIÊNCIAS DE FAMÍLIAS COM FILHOS TRANSEXUAIS A PARTIR DA TEORIA QUEER
Authors: Araujo Adrielly Oenning , Burtuli Carlos Eduardo Vasconcelos , Santos Lucimaira Cabreira dos
Published: November 2024

O gênero marca integralmente a vida dos sujeitos, constituindo seu local e vivência, possibilitando ou não sua presença e permanência nos espaços sociais. Este marcador baliza a vida do sujeito e seu campo relacional, atravessando outros corpos, assim como o núcleo familiar. Frente a este contexto, o presente estudo tem como objetivo interpretar a partir da teoria Queer se as famílias de pessoas transexuais se percebem como transgressoras do campo social. Para isso, realizamos uma revisão narrativa de literatura acerca do conceito da transexualidade a partir da teoria Queer e relações familiares; entendemos como esta experiência de ser genitores de sujeitos trans é vivenciada pelas figuras parentais e o impacto nas relações estabelecidas com os filhos; identificamos se as famílias percebem e vivenciam experiências de preconceito e discriminação em diferentes contextos; localizamos se as referidas famílias tiveram acesso a profissionais de saúde e como avaliam essa atuação e o impacto para a promoção da saúde dos membros desse grupo familiar. Foi executada uma pesquisa qualitativa, onde foram entrevistadas 3 genitoras de pessoas transsexuais, a coleta de dados ocorreu no formato virtual, por meio da plataforma de mensagens WhatsApp e presencial, onde foi aplicado um questionário sociodemográfico e uma entrevista semiestruturada, elaborados pelos pesquisadores. Os dados coletados foram interpretados a partir da análise temática de Minayo, onde foi possível significar e se debruçar acerca da fala dos participantes, visando o esclarecimento das questões levantadas. Constatou-se que familiares de pessoas transexuais se percebem como transgressores sociais, enfrentando preconceitos, sentindo o impacto da transição em suas próprias relações.
Agricultural and Non-Agricultural College Students' Attitudes Towards Undocumented Migration
Authors: Lamino Pablo , Duran Carlos , Ceme Renzo , Boren-Alpízar Amy
Published: November 2024

An estimated 4,350,000 immigrants reside in Texas, comprising 20% of the workforce and wielding a spending power of up to $112.8 billion. Negative sentiment towards migrants has created a hostile environment, despite their substantial socio-economic contributions. Efforts to mitigate this sentiment involve youth education, targeting younger generations to reshape perceptions about immigrants and emphasize diversity's significance. This research assesses undergraduates' attitudes toward undocumented migration and compares agricultural (AGNR) and non-agricultural (non-AGNR) students' stances. In this quantitative study, 452 participants completed the 20-item Attitude Toward Illegal Immigration survey, assessing constructs like cost-benefit, free flow, and human rights. Descriptive statistics, Mann-Whitney U tests, and multiple regressions were employed to analyze and compare Free flow (Model 1), Cost-Benefits (Model 2), Human Rights (Model 3), and the average attitude towards undocumented migration (Model 4). Results revealed a significant difference in undocumented migration scores. AGNR students slightly leaned against undocumented migration versus non-AGNR peers. Multiple regressions showed gender, ethnicity, and political inclination as significant predictors in both AGNR and non-AGNR models (cost-benefit, free flow, human rights, and undocumented migration). Further research should delve into these predictors' underlying reasons and replicate analyses in other US universities US using different approaches, such as a qualitative design.
Leveraging Brokers and Social Learning to Support Post-Pandemic Leadership Learning
Authors: Traini Haley , Baumgartner Natalie , Velez Jonathan
Published: November 2024

The COVID-19 pandemic and subsequent responses affected students of all ages academically, mentally, and emotionally. As leadership educators, we felt compelled to respond to adjust our programming and pedagogy for a post-pandemic era. This study aimed to explore the experiences of the first-year college of agricultural science students who engaged in an intentional community of practice about leadership. We used a case study approach and a social learning theory to specifically investigate how a social learning environment and the use of brokers contributed to student leadership trajectories. We found that student leadership trajectories shifted because of engaging in a caring community with the aid of candid and connected brokers. A small class size, multiple connections with an industry professional, and a course centered on student voice resulted in new confidence and plans to pursue future leadership opportunities.
The Role of Facebook Group Features for Travelers and Tourism Service Providers in Planning a Trip to Bali
Authors: Zuraida Lukia , Suriana I Putu Koisuki , Ghani Bima Maula
Published: November 2024

Social media has become a major source of inspiration, reference, and decision-making in planning a travel trip. This study aims to determine the influence of Facebook public group features on tourist trip planning decisions and the implications of using this feature on tourism service providers. The data collection was carried out in two ways, the first by providing a list of questions to informants online and the second by conducting semi structured interviews with tourists and tourism service providers who use Facebook public group feature. Data were analyzed using NVivo 12 Pro to identify meaningful patterns. The results show that it is divided into two categories, the point of view of travelers and tourism service providers. It identified four main roles from a traveler's perspective: activeness, sources of information, reviews and recommendations, and weaknesses.Three main roles emerged from the perspective of tourism service providers, including the utilization of interactions' output, threats, weaknesses, and competitive conditions in the field. The patterns of interactions in Facebook public groups demonstrate the findings.
La costumbre internacional como precedente en los cursos de aguas internacionales: Caso aguas del Silala. Chile v. Bolivia
Authors: Recalde Moncayo Thomas Sebastián , Martínez-Moscoso Andrés
Published: November 2024

Resumen:
El trabajo estudió los parámetros utilizados por la Corte Internacional de Justicia en el caso de las aguas del Silala que enfrentó a Chile y Bolivia. Para lo cual se usaron tanto los principios del Derecho Internacional del Agua, así como los desarrollados por este alto tribunal de justicia respecto a los cursos de agua internacional. Se determinó el rol que tuvo la costumbre internacional para la resolución de la controversia, así como la necesidad de un mayor desarrollo de los principios derivados de la costumbre internacional para casos análogos en el futuro, todo lo cual permitirá una mayor optimización y preservación de las cuencas transfronterizas.
Abstract:
The paper studied the parameters used by the International Court of Justice in the Silala water case between Chile and Bolivia. For this purpose, the principles of International Water Law were used, as well as those developed by this high court of justice with respect to international watercourses. The role played by international custom in the resolution of the controversy was determined, as well as the need for further development of the principles derived from international custom for similar cases in the future, all of which will allow for greater optimization and preservation of transboundary basins.
Palabras clave: Derecho del Agua. Corte Internacional de Justicia. Cursos de agua internacional. Derecho Internacional. Silala.
Keywords: Water law. International Justice Court. International water courses. International Law. Silala.
Índice:
1. Introducción
2. Teorías relativas a los cursos de aguas internacionales
3. Principios de los cursos de agua internacional
3.1. Uso equitativo y razonable
3.2. La prohibición de causar daño sensible
3.3. La obligación de cooperar entre Estados
3.4. La obligación de notificar y consultar
3.5. La soberanía de los Estados
4. Marco integrador de los principios de gobernanza hídrica
5. Estudio de la jurisprudencia de las aguas del Silala
5.1. Argumentos y peticiones de Chile
5.2. Reconvenciones presentadas por Bolivia
6. Comentarios a la sentencia de la Corte Internacional de Justicia
7. Conclusión
8. Bibliografía
Index:
1. Introduction
2. Theories relating to international watercourses
3. Principles of international watercourses
3.1. Equitable and reasonable use
3.2. The prohibition of causing significant harm
3.3. The obligation to cooperate between States
3.4. The obligation to notify and consult
3.5. Sovereignty of States
4. The integrative framework of the principles of water governance
5. Study of the jurisprudence of the waters of the Silala
5.1. Arguments and petitions of Chile
5.2. Counterclaims presented by Bolivia
6. Comments on the Judgment of the International Court of Justice
7. Conclusion
8. Bibliography
Nanotechnology-based Materials for Sustainable Pest and Disease Control in Agriculture
Authors: Mohapatra Rashmi , Giri Damayanti , Krishnaveni S. Anandha , G.Malathi  , Senthilkumar T , Gomadhi G. , Deivamani M. , Sasikumar K.
Published: November 2024

Nanotechnology is emerging as a transformative tool in agriculture, offering innovative approaches for sustainable pest and disease management. The incorporation of nanomaterials into agricultural practices has the potential to address the limitations of conventional pesticides and fertilizers, providing targeted, efficient, and eco-friendly alternatives. This review examines the current advancements in nanotechnology-based materials for sustainable pest and disease control, focusing on their mechanisms of action, environmental benefits, and challenges. Nanomaterials such as nanoscale pesticides, nano-formulated fertilizers, and smart delivery systems can significantly enhance the precision of agrochemical application, reducing chemical runoff and minimizing harm to non-target organisms. These materials offer controlled release properties, ensuring prolonged effectiveness and reducing the frequency of applications. Additionally, the use of nanoparticles can disrupt pest resistance mechanisms, providing a novel approach to resistance management, the promising benefits, the adoption of nanotechnology in agriculture is not without challenges. Key concerns include the potential environmental and health risks associated with the long-term use of nanomaterials, the cost of production, and the need for clear regulatory frameworks, biodegradable and environmentally friendly nanoparticles are being developed to mitigate some of these risks.
The Morphology and Topography of Portal Vein Root and Tributaries in Pig
Authors: Zagrai G. , Dumitrescu I. , Mihai Sorina Andreea , Gagniuc Elvira , Grama Aureliana , Belu C. , Damian A.
Published: November 2024

The study of the circulatory system in pigs is of major concern for anatomists, as the swine model is widely used in experimental cardio-vascular surgery. Although the vascularization of the cavities it is not a totally unknown „territory”, we noticed that any morphological study on the vasculature of the abdominal cavity and especially of the liver, offered new elements, appreciated by those who focus on the therapy of cardio-vascular diseases. The study was conducted within the Anatomy Laboratory of the Faculty of Veterinary Medicine in Bucharest. The research was conducted on approximately one-month old piglets, using the method of injecting the vessels with a contrast substance. This substance named Latex FDS195, has been used for the first time in our lab, and has been considered very efficient. As a result of the study, individual variants which have not been mentioned in specialized literature were described: the jejunal veins form structures in the shape of networks of fine vessels where the venous formations intertwine with the arterial ones. These aspects have not been described in detail in other scientific works. Recommendations of practical importance were also specified (the role of the networks on the jejunal artery route and the importance of knowing the topography of the caudal mesenteric artery for intrarectal administration of substances). Our results show that detailed knowledge of normal anatomy is crucial to avoid complications and ensure the success of liver surgery. Thus, we recommend that surgeons pay special attention to this aspect and be prepared to manage the variations of the hepatic pedicle properly. It is important that this knowledge is integrated into surgical training and practice to ensure the safety and success of interventions in the liver area
Determinantes Sociales y Salud Pública en Usuarios del Hospital Regional Hermilio Valdizán Medrano, Huánuco-2023
Authors: Dávila Cárdenas Isabel , Zavalaga Bustos Carmen Elvira , Lovón Rondón Ortzi Fortunato , Domínguez Montalvo Glizet Teresa
Published: November 2024

El trabajo de investigación “Determinantes sociales y salud pública en los usuarios del Hospital Regional Hemilio Valdizán Medrano, Huánuco-2023” tuvo como objetivo general, precisar la influencia de los determinantes sociales en la salud pública de los usuarios del mencionado Hospital Regional Hermilio Valdizán Medrano; en respuesta a la formulación del problema ¿En qué medida los determinantes socio-económicos-culturales influyen en la salud pública de los usuarios del Hospital Regional Hermilio Valdizán Medrano de Huánuco? Es una Investigación aplicada con metodología cuantitativa, con diseño transeccional descriptivo-explicativo. Se trabajó con una muestra probabilística de 380 usuarios de dicho hospital, de 18 a más años, residentes del departamento de Huánuco; con la técnica de la encuesta, aplicándose un cuestionario de 34 preguntas. Como resultados tenemos que la mayoría de los usuarios son casados o convivientes, siendo en su mayoría usuarias mujeres de la provincia de Huánuco que no participan en ningún programa social. Los usuarios trabajan en condiciones de eventualidad, autoempleo y precariedad laboral. El ingreso económico familiar es de pobreza y extrema pobreza. Los usuarios no perciben que la atención de salud se dé en igualdad de oportunidades. En general concluimos que existen determinantes sociales, económicos y culturales que inciden negativamente en la salud de los usuarios del Hospital; y que el estado de la salud pública de los usuarios se expresa en las enfermedades que padecen tales como enfermedades del sistema digestivo, golpes y accidentes y enfermedades genitourinario.
Prospective SARS-COV2 Surveillance in Shelter Cats Undergoing Ovariohysterectomy at a Veterinary Teaching Hospital
Authors: Carney Patrick C. , Thompson Nina , Kirch Pati J.
Published: November 2024

A total of 113 intact female shelter cats between approximately 5 and 18 months of age presented to a veterinary teaching hospital for ovariohysterectomy were surveilled for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) via polymerase chain reaction (PCR) and serology in an observational cross-sectional design to preliminarily assess risks of animal-to-human transmission. Swabs were obtained from the conjunctiva, oropharynx, rectum, and haircoat for PCR analysis. One cat (0.9%) had a low-positive rectal PCR result for SARS-CoV2, but was negative on subsequent testing and did not seroconvert. All other cats were negative on all PCR samples and serology. In the study population, the risk of COVID-19 transmission, both conspecific and zoonotic, appears low.