bluuebunny/crossref_metadata_2025 huggingface dataset:
Potensi ekstrak daun gamal sebagai bahan antikanker terhadap sel kanker rongga mulut
Authors: Annistri Savrinda , Sandra Ferry , Oetomo Roeslan Boedi
Published: November 2024

Latar Belakang: Kanker rongga mulut merupakan karsinoma kepala dan leher yang tercatat sebagai peringkat ke-6 keganasan paling sering terjadi. Salah satu tumbuhan yang berpotensi sebagai terapi alternatif karsinoma kepala dan leher adalah daun Gamal atau yang selanjutnya disebut Gliricidia sepium Jacq karena memiliki zat antioksidan yang sering digunakan oleh masyarakat sebagai pengobatan tradisional. Tujuan: Review ini bertujuan untuk melihat kemungkinan penelitian masa depan tentang kanker mulut menggunakan ekstrak etanol daun G. sepium. Metode: Referensi pada review ini menggunakan pencarian jurnal terkait di PubMed, Google Scholar, laporan resmi dan jurnal kesehatan lainnya dengan kata kunci pencarian “kanker mulut”, “anti-kanker”, “Gliricidia sepium Jacq.”, “antioksidan” dan “apoptosis” dari tahun 2006 – 2023. Hasil Penelitian: Daun G. sepium kerap digunakan sebagai obat tradisional oleh masyarakat. Dilaporkan kegunaannya dalam pengobatan tradisional dapat dikaitkan dengan aktivitas farmakologisnya yang berfungsi sebagai ekspektoran, sedatif, supuratif, anti bakteri, anti jamur, dan anti virus. Penelitian sebelumnya didapatkan senyawa-senyawa metabolit sekunder yang terkandung sebagian besar dapat digunakan sebagai bahan anti-kanker. G. sepium juga dilaporkan memiliki kemampuan dalam menginduksi apoptosis pada kanker kolon HCT116, kanker payudara HCC 1935 dan prostat DU 145, serta berdasarkan hasil penelitian ekstrak petroleum eter G. sepium sangat anti proliferasi pada kanker prostat DU145. Namun, belum terdapat penelitian mengenai potensi G. sepium sebagai bahan anti kanker dalam menangani kanker mulut. Kesimpulan: Berdasarkan temuan, dapat disimpulkan bahwa daun G. sepium mampu berperan sebagai agen anti-kanker karena senyawa yang terkandung didalamnya. Penelitian lebih lanjut diperlukan untuk melihat aktivitas anti kanker G. sepium terhadap kanker mulut.
Aktivitas Antioksidan dengan Metode DPPH dan ABTS Terhadap Ekstrak Etanol Daun Amaranthus hybridus L.
Authors: Dewi Ranggaini Monica , Halim Johni , Aurelia Tjoe Michelle
Published: November 2024

Background: Cancer, a degenerative disease, arises from free radicals in the body, which can be counteracted by antioxidants. Amaranthus hybridus L., a vegetable rich in antioxidant compounds like flavonoids, requires extraction to harness these compounds. This extraction uses the maceration technique with 70% ethanol. Antioxidant activity is tested using methods like DPPH and ABTS assays, with the IC50 value indicating effectiveness. Purpose: To determine the difference in antioxidant activity of A. hybridus L. leaves ethanol extract with DPPH and ABTS methods. Method: Laboratory experimental research. Simplicia leaves of A. hybridus L. in 70% ethanol solvent were extracted using maseration method. The antioxidant activity was tested in the sample and the ascorbic acid using DPPH and ABTS methods at wavelenghts 517 nm and 745 nm. Sample absorbance was measured using microplate reader. Result: IC50 values of A. hybridus L. leaves ethanol extract with DPPH and ABTS methods were 54,99 µg/mL and 71,45 µg/mL, for ascorbic acid using DPPH and ABTS methods were 0,62 µg/mL and 3.13 µg/mL. Conclusion: The antioxidant activity of A. hybridus L. leaves ethanol extract with DPPH method has stronger antioxidant than ABTS method.
Penatalaksanaan jaringan gingiva dalam penggunaan retraction cord
Authors: Pratama Sarwono Aditya , Fitriyasari Rahmah
Published: November 2024

Introduction: Tooth loss affects a person's appearance and health, impacting their quality of life. Teeth play an essential role in chewing and aesthetics, particularly the anterior teeth. Dental trauma such as fractures can affect appearance and psychology, reducing self-confidence. Currently, aesthetics is a top priority in dental care. Tooth loss leads to complex oral problems, thus missing teeth need to be replaced with dentures. Methods: This study explores the use of various gingival retraction techniques before impression taking in prosthodontic treatment. The methods analyzed include mechanical, chemical, and surgical techniques, with a focus on retraction using retraction cords soaked in hemostatic agents to ensure accurate and blood-free gingival margins before impression taking. Discussion: Accurate impressions depend on proper tooth preparation and healthy soft tissue conditions. Effective gingival retraction is crucial for obtaining good impressions, especially at the cervical and gingival margins. Mechanical methods using retraction cords are commonly used due to their effectiveness, speed, simplicity, and affordability. However, chemical methods may pose risks to the gingiva, while surgical methods are more complex. Conclusion: Accurate impressions for fixed dentures require healthy soft tissues without periodontal disease. Gingival retraction before impression taking is essential for achieving accurate impressions, ensuring that the cervical margins are well defined. Retraction methods include mechanical, chemical, and surgical approaches, with mechanical methods being the common choice due to their effectiveness and simplicity.
Gambaran sefalometri pasien usia 8-11 tahun menggunakan analisis jarabak
Authors: Hobibah Muqodariah Ratu , Piona Sahelangi Olivia
Published: November 2024

Background: Cephalometry used to determine growth patterns and study craniofacial structures. Jarabak analysis, interprets the morphological characteristics of the mandible with other craniofacial structures. Objective: Obtain the mean value of cephalometric measurements based on Jarabak analysis in orthodontic patients aged 8-11 years at RSGM-P FKG Usakti. Methods: Descriptive observational research by tracing 104 cephalograms each consisting of 52 female and male. Results: The mean values of female angle measurements are, saddle angle 126˚ articulare angle 143˚ gonial angle 131˚ Jarabak sum 399˚ upper gonial angle 53˚ lower gonial angle 78˚. Linear measurements obtained the value of S N 58mm Go Me 57mm S Ar 28mm Ar Go 34mm S Go 59mm N Me 99mm, Jarabak ratio 59%. The mean values in male angle measurements are, saddle angle 124˚ articulare angle 143˚ gonial angle 130˚ Jarabak sum 399˚ upper gonial angle 53˚ lower gonial angle 77˚. Linear measurements obtained the value of S N 59mm Go Me 58mm S Ar 29mm Ar Go 35mm S Go 61mm N Me 99mm, Jarabak ratio 61%. Conclusion: Three female and male angular measurements, and one male linear measurement were equal to the Jarabak analysis norms. One female and one male linear measurement was greater than the Jarabak analysis norm.
Perbandingan splinting kawat komposit dengan splinting fiber reinforced composite untuk stabilisasi mobilitas gigi
Authors: Purnomo Racheliza , Albert
Published: November 2024

Background: Tooth mobility is a periodontal disease accompanied by loss of periodontal ligament attachment and bone destruction. Treatment for stabilization of loose teeth is splinting. The two most commonly used materials are composite wire splinting and fiber reinforced composite splinting. However, there is a dilemma in the community regarding the selection of materials that are more effective for the immobolization of loose teeth. Objective: The purpose of this study was to compare the effectiveness between composite wire splinting and fiber reinforced composites splinting for the stabilization of loose teeth. Methods: The study was conducted using the PRISMA diagram with PubMed, Researchgate, Tripdatabase and Google Scholar databases by searching ("Periodontal Splinting" Or "Wire Splinting" Or "Fiber Reinforced Composite Splinting") And ("Periodontitis"). Results: The initial search showed 385 articles. After removal of duplicates and complete screening of journals for eligibility, the results were 14, and the researcher identified 5 articles that met the criteria for inclusion in this study. Conclusion: Based on the results of the study, it can be concluded that composite wire splinting is more effective than fiber reinforced composite splinting because it effectively reduces tooth mobility and is more stable for loose teeth.
Potensi buah zanthoxylum acanthopodium dc. dalam menghambat kanker rongga mulut
Authors: Syafiqa Amelia Dinda , Sandra Ferry , Ihsan Rizal Muhammad
Published: November 2024

Background(s): Oral cancer is one of the most highly prevalent cancers with high mortality rate. Advanced-stage cancer often treated with chemotherapy. Chemotherapy does not differentiate between killing tumor cells and normal cells, leading to a range of side effects. Identifying effective approaches with minimal side effects for cancer treatment remains a significant priority within the medical field. Objective(s) : This review aimed to investigate potential avenues for future research on oral cancer using Z. acanthopodium  Method(s) : References for this article were determined through searches of PubMed, Google Scholar, and official websites of global health organizations. The search terms were “cancer”, “oral cancer”, “anticancer”, “Zanthoxylum acanthopodium”, “apoptosis” from 2014 to 2024. Main finding(s) : Phytochemical compounds found in plants have a significant role in cancer therapies. Z. acanthopodium fruit has been used in anticancer research due to its wide array of bioactive compounds. Previous studies have shown the anticancer properties of Z. acanthopodium DC.  against blood and breast cancer cell lines. Research on its anticancer activity against oral cancer has never been reported. Conclusion(s) : Recent findings confirm Z. acanthopodium as a rich source of bioactive compounds with potential anticancer properties. Further research on its anticancer activity against oral cancer should be promoted.
Uji Three Point Bending Kawat Nikel Titanium Dimensi 0,010 x 0,030 Inci yang digunakan sebagai retainer
Authors: Diva Gama Putri Salsabila , Hamonangan Nasution Fajar , Gadih Pratomo Harris
Published: November 2024

Background: Fixed retainer are a practical retention method because they require minimal cooperation from the patient. Fixed reteiner are made from various types of wire, one of which is nickel titanium. However, when using a fixed retention device, several problems arise, such as fracture of the wire, loss of bond between the surface of the wire and composite, failure of attachment of the composite to the teeth, and unexpected tooth movement. Objective: To determine the shape memory and superelastic properties of nickel titanium wire with dimensions of  0.010 x 0.030 inches used as a retention device after a three point bending test.  Method: This research is a laboratory experimental study using 5 samples of nickel-titanium wire measuring 0.010 x 0.030 inches. The wire length is 30 mm. The collected data was then tested using a tested. Results: Nickel titanium wire measuring 0.010 x 0.030 inches with a deflection of 1.5 mm shows a graph with a smaller hysteresis than a deflection of 2 mm with a wider hysteresis. Nickel-titanium wire measuring 0.010 x 0.030 inches with a deflection of 1.5 mm and 2 mm shows that the wire experiences permanent deformation before returning to its initial shape, which could be due to the amount of deflection applied exceeding the tensile yield strength range limit of the wire. Conclusion: The amount of deflection given to the nickeltitanium wire samples is 1,5  mm and 2 mm influences the amount of force released. The deflection of a given wire determines how much force can be generated when the wire is applied.
Karies gigi terhadap balita stunting dan gizi buruk
Authors: Alicia Wongkar Michelle , Asia Rr. Asyurati , Talenta Theresia Tiarma
Published: November 2024

Parents' knowledge of the health of toddlers, especially mothers, is very important in sustaining the good growth of toddlers. The mother's knowledge of the nutritional factors and oral health of toddlers is something that must be considered so that when the toddler is in the womb until birth. Insufficient maternal knowledge can have a negative impact on the child's health, disrupting growth such as stunting and malnutrition.
Hipomania induzida por aripiprazol em uma paciente com depressão resistente ao tratamento
Authors: Monteiro Dennison Carreiro , Oliveira João Cortez de , Medrado Thamires da Silva Sampaio , Cardoso Víctor Câmara Gusmão , Régis Vitor Gama Vieira de Araújo
Published: November 2024

Introdução: O aripiprazol é classificado como um antipsicótico atípico de terceira geração e amplamente utilizado nos transtornos psicóticos, episódios de mania/hipomania e no transtorno depressivo maior resistente ao tratamento. Exerce sua ação através do agonismo parcial nos receptores dopaminérgicos D2 e no serotoninérgico 5-HT1A, além do antagonismo nos receptores 5-HT2A, sendo a indução de mania/hipomania um evento considerado raro. Apresentação do caso: Este relato descreve o caso de uma mulher de 63 anos, com transtorno depressivo persistente, que apresentou quadro de hipomania logo após iniciar aripiprazol em baixa dose (5 mg em dias alternados), para potencialização antidepressiva. Método: Relato de caso. CAAE: 82055624.7.0000.5192 Parecer N. 7.062.61  Discussão: A prescrição do aripiprazol em doses reduzidas tem efeito predominantemente “estimulante”, podendo desencadear sintomas de hipomania/mania. Constata-se que os sintomas podem iniciar de maneira precoce e que não há indícios de relação entre a quantidade de medicamento prescrito e o momento de início, intensidade ou duração das mudanças de humor. A prevalência real desses eventos pode ser subestimada, frequentemente confundidos com acatisia, dificultando o diagnóstico. Conclusões: Destaca-se a necessidade de cautela e vigilância quanto a eventuais alterações de humor quanto prescritas baixas doses de aripiprazol para pacientes com transtorno depressivo resistente.
Situación actual del aprovechamiento por turno de bienes inmuebles en España. Especial referencia a la jurisprudencia reciente del Tribunal Supremo
Authors:   Universidad de La Laguna (España), Chulani Raymond Jagdish Kumar
Published: November 2024

Real estate timesharing is a recently created right that is characterized by the concurrence of personal, real and formal elements. In addition to the fulfilment of certain prerequisites, we can add that it is a right with its own legal regime in terms of constitution, modification, content, duration or termination. Moreover, the right of withdrawal and the prohibition of payment of advances offer consumers special protection.
Current Landscape of Melanoma Clinical Trials Involving Artificial Intelligence
Authors: Reddy Raghuram , Santoyo Karla C.
Published: November 2024

Objective: Leveraging advanced artificial intelligence (AI) tools can enhance melanoma diagnosis and care by supporting physician decision-making. Methods: A search for melanoma studies using AI was conducted on ClinicalTrials.gov (US National Library of Medicine) on August 20, 2024. Results: 26 studies involving melanoma and artificial intelligence resulted from the search with a total enrollment size of 69,609 people. Recruitment status for these 26 studies were as follows: 1 study (3.85%) was not yet recruiting, 6 (23.08%) were recruiting, 3 (11.54%) were active/no recruiting, 9 (34.62%) were completed, 2 (7.69%) were enrolling by invitation, and 5 had an unknown status. Concerning age, 5 studies included children (birth-17 years), 25 (96.15%) included adults (18-64 years), and 25 (96.15%) included older adults (65+ years). Regarding study type, 10 studies (38.46%) were interventional studies, and 16 (61.53%) were observational. In terms of funding, 6 studies (23.08%) were funded by industry, whereas 23 studies (88.46%) were funded by other sources. Sweden was the location for the most studies (n=4, 15.38%), followed by Spain (n=3, 11.54%) and United Kingdom (n=3, 11.54%). 21 studies (80.77%) focused on AI-aided diagnosis of melanoma (3.85%), based a variety of techniques ranging from total-body photography to mole-mapping over time. Conclusion: Artificial intelligence is poised to significantly impact melanoma care by improving early diagnosis and being integrated into the Mohs micrographic surgery workflow.
Tensão entre monoteísmo e politeísmo na Bíblia Hebraica e no Antigo Israel
Authors: Yan Anderson
Published: November 2024

The article analyzes the tension between monotheism and polytheism in the Hebrew Bible (HB) and the religion of ancient Israel, proposing that the development of monotheism was a gradual and multifaceted process. The study examines biblical passages and archaeological evidence suggesting the coexistence of polytheistic beliefs alongside the predominant worship of Yahweh. The author discusses the use of terms such as henotheism and monolatry to describe the religious phenomenon in ancient Israel, arguing that monotheism only fully consolidated during the exilic period. The applied methodology includes the distinction between “emic” and “etic” approaches, allowing for a contextualized analysis of religious practices without imposing modern concepts. Additionally, the article explores the influence of other deities, such as El, Asherah, and Baal, on Israelite religiosity, suggesting that the transition to monotheism involved a process of assimilation, exclusion, and transformation of religious practices. The conclusion is that Israelite monotheism did not emerge abruptly, but as the result of a long theological and political reflection, with both external and internal influences shaping religious thought over time.
Editorial
Authors: De Bona Stahlhoefer Alexander
Published: November 2024

Leitartikel der Ausgabe 27/3
One method of optimal control searching in a heterogeneous discrete systems with a delay in the state of processes
Authors: Блинов Александр Олегович , Расина Ирина Викторовна
Published: November 2024

Рассматривается класс неоднородных дискретных систем (НДС)
с промежуточными критериями, содержащих два уровня. Системы нижнего
уровня включают в себя переменные состояния с запаздыванием. Такие НДС
представлены на практике и получаются в процессе дискретизации
непрерывных систем при решении задач оптимизации итерационными методами.
Для указанного класса предлагается аналог достаточных условий
оптимальности Кротова, на основе которого строится метод улучшения
управления. Предлагаемый метод проиллюстрирован примером.
A heuristic algorithm for one nonlinear optimal control problem
Authors: Гусева Ирина Сергеевна , Расина Ирина Викторовна
Published: November 2024

Рассматривается задача оптимального управления для одного
из вариантов квазилинейной системы. Для ее решения используется идея
профессора В. И. Гурмана, предложившего сочетать два варианта принципа
расширения. Один из них, традиционный подход Кротова, а второй - метод
штрафных функций. Выбранный класс систем позволяет провести
аналитическое исследование лагранжиана Кротова, что в свою очередь
приводит к формулировке алгоритма. Полученный алгоритм апробирован
на двух иллюстративных примерах, для которых построены минимизирующие
последовательности. Трудоемкость расчетов сопоставима с методами,
основанными на традиционном принципе расширения. Результаты расчетов
проиллюстрированы таблицами и графиками.
Unmet Palliative Care Needs of Patients with Stage B Chronic Heart Failure Classified by the American Heart Association/American College of Cardiology
Authors: Matsunuma Ryo , Yamaguchi Takashi , Matsumoto Kensuke , Sakashita Akihiro , Hashiguchi Chikako , Iida Masashi , Kizawa Yoshiyuki
Published: November 2024

This study sought to explore the unmet palliative care needs of patients diagnosed with Stage B chronic heart failure (CHF) according to the American Heart Association (AHA) and American College of Cardiology (ACC) classifications. We conducted this cross-sectional study between June 1 and August 31, 2020, at Kobe University Hospital. Patients were asked to complete the Integrated Palliative care Outcome Scale (IPOS) along with a customized questionnaire developed by a multidisciplinary team. These tools were filled out by the patients themselves or with help from family members. A total of 101 patients participated in the study, with 55 of them (55%) falling into the Stage B CHF group as classified by AHA/ACC. Among the physical symptoms, 22% reported dyspnea and 20% reported drowsiness as common concerns. Regarding specific problems, 47% identified issues related to exercise, 62% with eating, 26% with finances, and 18% with employment. Notably, financial difficulties were found to be significantly more common among Stage B patients when compared to those in Stages C and D (odds ratio [OR]: 5.22; 95% confidence interval [95% CI]: 1.03–26.5; p = 0.032). Almost 79% of Stage B patients expressed a desire to understand the progression of their disease. In conclusion, stage B CHF patients may face financial difficulties and have unmet informational needs. Therefore, further research is necessary to explore these aspects in greater detail.
Very late intracranial extraparenchymal solitary metastasis of adenoid cystic carcinoma of the parotid gland: A case report and literature review
Authors: Anami Hidenori , Shiwa Tomoko , Nonaka Taku , Nakano Hiroshi , Hashimoto Ryosuke , Yamada Masatoshi , Kobayashi Tomonori
Published: November 2024

Background:

Adenoid cystic carcinoma (ACC) of the parotid gland often manifests as distant metastasis long after the initial surgery, resulting in a poor long-term prognosis. The most common sites of metastasis are the lungs, liver, and bones. Single intracranial metastasis is very rare.

Case Description:

A 43-year-old woman with a history of surgical removal of ACC 24 years prior presented with Gerstmann syndrome and right hemianopsia. Head magnetic resonance imaging revealed a solitary extra-axial tumor in the left occipital region. The tumor was surgically removed and pathologically diagnosed as a metastasis of cribriform-type ACC. Since she had no other systemic metastasis, she did not receive adjuvant treatment and has remained recurrence-free for 35 months postoperatively.

Conclusion:

Very late intracranial solitary metastasis of ACC is extremely rare. Due to the risk of delayed recurrence in pathologically confirmed cribriform type ACC, long-term follow-up is recommended.
Giant scalp dermatofibrosarcoma protuberans at mid-occipital scalp: A rare case report
Authors: Hakim Muhammad Luqman Nul , Tjahjono Firman Priguna , Faried Ahmad
Published: November 2024

Background:

Dermatofibrosarcoma protuberans (DFSP) is a rare type of skin cancer that arises in the deeper layers of the skin, most commonly on the trunk and limbs. The presentation of DFSP on the scalp is worth documentation due to its extremely rare occurrence in the literature.

Case Description:

We describe a case of a 41-year-old female presented with a lump on the back of the head with gradual enlargement. It was solitary with a size 19 × 12 × 10 cm with purulent discharge and intermittent pain. A computed tomography-scan showed an isodense mass at mid occipital without intracranial involvement. Tumor extirpation and the free flap were performed collaborated with plastic surgery. The patient was discharged unremarkably on the 7th postoperative day without any neurological deficits.

Conclusion:

Our case is distinct because, after 24 months without any adjuvant therapy and without any recurrence, the patient is still doing well. This is a very rare clinical entity.
Penetrating intraorbital wooden foreign bodies involving the right frontal lobe of the brain: A rare case report
Authors: Wardhana Donny Wisnu , Bal’afif Farhad , Nazwar Tommy Alfandy , Rosyada Amrina , Putro Wahju Sigit Tjahjono , Kholipah Anisa Nur
Published: November 2024

Background:

Penetrating orbital trauma from a wooden foreign object is rare and challenging to identify, as it cannot be detected with a computed tomography (CT) scan. This report highlights the clinical presentation, diagnosis, and management of such a case.

Case Description:

A 19-year-old female experienced penetrating orbital trauma from a wooden object following a traffic accident. She intermittently visited the hospital with eye swelling and headache, without visible penetrating wounds on the palpebra. The swelling persisted for weeks, accompanied by increasing signs of ocular and cerebral infection. The suspicion of a non-metallic foreign body penetrating the brain was confirmed 3 months after the initial visit, delayed by the hidden entry wound between the eyelid and eyeball and orbital edema mimicking non-penetrating trauma. A multidisciplinary team managed the case. Procedures included debridement, retro-orbital exploration, retro-orbital abscess evacuation, and frontal basal trephination exploration, successfully removing the wooden object that had penetrated the medial orbit, frontal bone, and brain, along with cerebral abscess evacuation. Postoperative CT scans showed complete removal of the foreign object and successful abscess evacuation. The patient showed improvement in ocular symptoms, resolution of headaches, and no wound leakage. She was discharged on the 14th day after completing antibiotic treatment and having the dressing removed.

Conclusion:

This case is notable for its rarity, high risk of misdiagnosis, and potentially fatal consequences if not promptly managed. We emphasize the importance of patient involvement in routine consultations, careful anamnesis, clinical examination, and a multidisciplinary approach for optimal outcomes.
ВНЕДРЕНИЕ НАЛОГОВОГО МОНИТОРИНГА В РАМКАХ ИННОВАЦИОННОГО РАЗВИТИЯ ОРГАНИЗАЦИЙ
Authors: Е.М. Акимова , Е.Ю. Васильева
Published: November 2024

По мнению авторов, налоговый мониторинг способен стать одной из важнейших управленческих инноваций в современных крупных организациях. В статье рассматриваются содержание и функции налогового мониторинга. Исследованы три возможных пути постановки в организации налогового мониторинга, их достоинства и недостатки. Авторами сделан вывод о том, что наиболее перспективным из них является переход на так называемую налоговую витрину. Представлены этапы развертывания налоговой витрины в организации, сформулированы условия, необходимые для ее успешного становления в организации.
ИННОВАЦИОННЫЕ ТЕНДЕНЦИИ В ДЕВЕЛОПЕРСКОЙ ДЕЯТЕЛЬНОСТИ
Authors: Ю.О. Бакрунов , Е.Ю. Васильева
Published: November 2024

Авторы статьи рассматривают основные инновационные тенденции, распространившиеся в деятельности девелоперских компаний России. Выявлены основные преимущества, которые могут быть достигнуты благодаря инновационному развитию: сокращение сроков строительства, повышение качества строительной продукции, распространение энергоэффективных технологий, создание «Умных домов». С другой стороны, в статье выявлены проблемы инновационного развития, такие как дефицит финансовых ресурсов, несовершенство методики оценки эффективности инновационных проектов, недостаток квалифицированных кадров. способных осваивать инновации. Рассмотрены пути преодоления этих проблем.
ПЕРСПЕКТИВЫ РАЗВИТИЯ ESG-ФИНАНСИРОВАНИЯ КАК ИННОВАЦИОННОГО ПОДХОДА К ПРИВЛЕЧЕНИЮ РЕСУРСОВ КОМПАНИЯМИ РОССИИ
Authors: Е.Ю. Васильева , Ю.О. Бакрунов
Published: November 2024

В статье рассматривается такая прогрессивная и инновационная тенденция в сфере инвестиций, как ESG-финансирование, предполагающее ответственное устойчивое развитие. Выявлены основные драйверы устойчивого развития в России, проанализировано влияние критериев ESG на стоимость акций и доходность корпоративных облигаций. Установлены достижения в этом направлении в России к началу 2022 г. и проанализированы основные проблемы ESG-финансирования после введения антироссийских экономических санкций в феврале-марте 2022 г. Высказаны предположения о перспективах и направлениях дальнейшего развития ESG-финансирования в нашей стране, в качестве нового ориентира названо сотрудничество с дружественными станами Азии и арабского мира.
ОСОБЕННОСТИ УПРАВЛЕНИЯ ПЕРСОНАЛОМ В ОРГАНИЗАЦИЯХ СТРОИТЕЛЬНОЙ ОТРАСЛИ РОССИЙСКОЙ ФЕДЕРАЦИИ
Authors: А.В. Пинегин
Published: November 2024

В статье рассмотрены ключевые особенности строительной отрасли, которые оказывают прямое влияние на процесс управления строительной организацией. Автором выделены ключевые проблемы компаний в строительной отрасли, предложены пути их решения. Рассмотрены документы являющиеся нормативно- правовой базой в строительной отрасли, а также выделены группы документов в вопросах управления персоналом. Также в данной статье разобраны этапы повышения квалификации уровня сотрудников и выделена одна из наиболее актуальных проблем строительства в современных условиях, которая заключается в проблеме централизации оценки труда. Сделан вывод о том, что основной целью организаций строительной отрасли является получение максимальной прибыли, которая на прямую зависит от эффективности деятельности каждого сотрудника, По этой причине система управления персоналом на предприятиях крайне важна, однако руководителями организаций должны учитываться специфические особенности строительной отрасли.
ОБЩЕСТВЕННЫЕ ФИНАНСЫ РЕГИОНА В УСЛОВИЯХ САНКЦИОННЫХ ВОЗДЕЙСТВИЙ
Authors: П.А. Иванов
Published: November 2024

Статья посвящена рассмотрению аспектов формирования и исполнения доходной части консолидированного бюджета региона в условиях санкционного давления. Проанализированы положения Бюджетного кодекса РФ в части определения принципа эффективности использования бюджетных средств. Предложены обновленные формулировки данного принципа в части результативности использования бюджетных средств, обеспечивающие однозначность их трактовки как нацеленности на достижение результатов не ниже заданных (плановых). По результатам проведенного анализа состояния общественных финансов на примере консолидированного бюджета Республики Башкортостан установлено, что в кризисные периоды (2009 г., 2014 г., 2020 г.) наблюдается снижение доли бюджетной обеспеченности налоговыми и неналоговыми доходами от общего уровня доходов бюджета региона. Выявлены факторы, оказывающие влияние на поступления по основным бюджетообразующим налогам – налогу на прибыль организаций и налогу на доходы физических лиц: производство товаров и оказание услуг с различным уровнем добавленной стоимости, наличие/отсутствие в регионе льготных налоговых режимов (в рамках особых экономических зон, территорий опережающего социально-экономического развития, специальных административных районов), доля сельского населения, объем банковских вкладов физических лиц на душу населения, доля компаний с иностранной формой собственности в финансово-инвестиционных результатах деятельности. Сделан вывод о необходимости анализа обратной связи от реализации принятых мер защиты граждан и бизнеса в условиях санкционного давления для выработки мероприятий по повышению бюджетной устойчивости территорий.
ПРОВЕРКА РАСЧЕТОВ С ПОДОТЧЕТНЫМИ ЛИЦАМИ
Authors: Т.Ю. Феофилова , А.А. Евграфов , Е.В. Радыгин
Published: November 2024

На основе обобщения ранее опубликованных подходов к проведению контрольных мероприятий предложена авторская методика проверки расчетов с подотчетными лицами с учетом требований к осуществлению внутреннего контроля к ведению бухгалтерского учета. Цель исследования состоит в развитии методического обеспечения процедур проверки по существу при выполнении задания внутреннего аудита, а также ревизии финансово-хозяйственной деятельности посредством уточнения методики проверки расчетов с подотчетными лицами. Методология исследования базируется на общенаучных методах, в частности на анализе и синтезе эмпирических данных, касающихся организации и проведения контрольных мероприятий в экономическом субъекте, а также на сравнении и эксперименте. Сформулированы цели и задачи проверки, разработан план, определены документы, подлежащие проверки. Изложены поэтапно действия ревизора по проверке расчетов с подотчётными лицами. Особенностью методики является изложение порядка оценки внутреннего контроля учетного процесса. Авторами разработаны ряд форм рабочих документов, которые расширяют методический инструментарий ревизии и внутреннего аудита и могут быть полезны в практической деятельности.
Evaluation of the clinical effectiveness of the wounds plastics using autologous red bone marrow aspirates
Authors:   Vitebsk State Order of Friendship of Peoples Medical University, Vitebsk, Belarus, Fedzianin S.D. , Stavchikov E.L. ,   Vitebsk State Order of Friendship of Peoples Medical University, Vitebsk, Belarus,   Mogilev Regional Clinical Hospital, Mogilev, Belarus, Kovalenko A.A. ,   Vitebsk State Order of Friendship of Peoples Medical University, Vitebsk, Belarus, Matusevich E.A. ,   Vitebsk Regional Clinical Hospital, Vitebsk, Belarus, Shilin V.E. ,   Vitebsk State Order of Friendship of Peoples Medical University, Vitebsk, Belarus
Published: November 2024

Backgraund: the treatment of patients with wound defects of soft tissues is a difficult task for the healthcare system. Despite the variety of methods, it is not always possible to achieve positive results. The development of new technologies aimed at stimulating of regeneration can help improve the results of skin plastic in the complex treatment of wounds. Aims: to study the clinical efficacy of the wounds plastics using autologous red bone marrow aspirates. Materials and methods: a prospective simple controlled randomized clinical trial was conducted on two parallel groups of patients. The study involved 84 patients with wounds that arose after surgical treatment of abscesses and phlegmons, surgical site infections and injuries. The main group consisted of 42 patients who used the technique of the wounds plastics using autologous red bone marrow aspirates. Indication for use of the method – wounds with the signs of chronicity of wound healing. The area of wounds defects was 24 (12; 32,5) cm2. The comparison group consisted of 42 patients who were treated using traditional methods. The area of wounds defects was 23,8 (11,98; 31,6) cm2. The planimetry was performed using ImageJ software. Statistical data processing was performed using Microsoft Excel 2018, Statistica 7.0 and IBM SPSS Statistics 22 programs. The differences between the groups were considered significant at p<0,05. Results: among 42 patients in the main group, in 33 (78,57%) wounds healed, in 6 (14,29%) – partial lysis was noted, in 3 (7,14%) – lysis of the skin flap. Among 42 patients in the comparison group, wound healing was observed in the 26 (61,9%) patients, partial flap lysis – in the 7 (16,67%) patients, and lysis – in 9 (21,43%) (p<0,05). Conclusion: the wounds plastics using autologous red bone marrow aspirates is characterized by a fairly high clinical efficacy. This approach significantly improved the results of autodermoplasty by 16,67%.
Evolution of mitral valve replacement
Authors:   The National Medical Research Center of High Medical Technologies – the Central Military Clinical Hospital of A.A. Vishnevsky, Krasnogorsk, Eliseev I.G. , Lischuk A.N. ,   The National Medical Research Center of High Medical Technologies – the Central Military Clinical Hospital of A.A. Vishnevsky, Krasnogorsk, Havandeev M.L. ,   The National Medical Research Center of High Medical Technologies – the Central Military Clinical Hospital of A.A. Vishnevsky, Krasnogorsk, Muzichin A.L. ,   RKB named after M.I. Kalinin, Donetsk, Komendantova Yu.V. ,   Russian State Social University, Moscow, Gitelzon E.A. ,   RUDN University, Moscow, Faibushevich A.G. ,   RUDN University, Moscow
Published: November 2024

The paper highlights the evolution of mitral valve prosthetics, from the first developments to modern innovative technologies. The history of development of prosthetic methods both in Russia and in the world, their effectiveness, advantages and disadvantages, as well as the latest developments in the practice and technology of mitral valve prosthesis are considered. The article also provides an overview of the results of clinical trials conducted using different types of prostheses and their impact on survival and quality of life of patients. The problems faced by physicians and researchers in this field are analyzed, and the prospects for the development of mitral valve prosthetics are discussed.
Varicose Veins in the Elderly Patients: Problems and Prospects
Authors:   SM-Clinic, Moscow, Shirinbek O. , Mnatsakanyan G.V. ,   SM-Clinic, Moscow, Odinokova S.N. ,   I.M. Sechenov First Moscow State Medical University, Moscow
Published: November 2024

Varicose veins of the lower extremities are quite common in the elderly population. The severity of venous disease is determined by the individual tolerance of the symptoms of varicose veins, taking into account the natural aging of the body and the existing comorbid status. This article provides an overview of the problem of varicose veins and chronic venous insufficiency in general and through the prism of patients of the older age group. The advantages and limitations of various approaches to the diagnostics and treatment of varicose veins in the gerontological patients are discussed and presented. Endovenous treatment modalities, specifically glue ablation, open new horizons of pain-free and radical treatment of varicose veins in the elderly patients.
Pulmonary embolism: assessment of the severity and prognosis of the outcome of the disease
Authors:   Pirogov National Medical and Surgical Center, Moscow, Pronin A.G. , Troshina A.A. ,   Pirogov National Medical and Surgical Center, Moscow
Published: November 2024

Predicting and preventing the development of death and chronic thromboembolic hypertension in patients with pulmonary embolism is one of the urgent problems of modern medicine. The introduction into clinical practice of stratification of the risk of early death from pulmonary embolism has made it possible to optimize the treatment of these patients in many ways. However, uncertainty remains in the choice of the volume of therapy in patients with moderate risk of early death. What underlies the often incorrect choice of treatment tactics and, as a result, the development of chronic thromboembolic pulmonary hypertension in these patients, more often than in other patients. Many researchers see ways to solve this problem in establishing new echocardiographic criteria for the severity of pulmonary embolism. This article analyzes modern literary data and the results of their own research. The superiority of determining the pressure gradient on the pulmonary artery valve, calculated on the basis of measuring the volume of the heart ejected into the aorta in one systole during echocardiography, over most widely used parameters is shown.
Endovascular management of rectal variceal bleeding in patients with cirrhosis and portal hypertension
Authors:   O.M. Filatov City Clinical Hospital №15, Moscow, Dzhurakulov S.R. ,   Pirogov Russian National Research Medical University, Moscow, Vechorko V.I. ,   O.M. Filatov City Clinical Hospital №15, Moscow,   Pirogov Russian National Research Medical University, Moscow, Severcev A.N. ,   O.M. Filatov City Clinical Hospital №15, Moscow,   Pirogov Russian National Research Medical University, Moscow, Fakhriev J.A. ,   O.M. Filatov City Clinical Hospital №15, Moscow,   RUDN university, Moscow, Hokonov A.M. ,   O.M. Filatov City Clinical Hospital №15, Moscow
Published: November 2024

Liver cirrhosis is one of the factors in the development of portal hypertension. Portal hypertension leads to dilation of collateral portosystemic veins along the gastrointestinal tract. The most common and serious complication of portal hypertension is varicose veins of the esophagus and bleeding from them. Less known, but no less dangerous, is bleeding from varicose veins of the lower gastrointestinal tract. The incidence of varicose veins occurs in 38–56% of patients with liver cirrhosis. Confirming the diagnosis is often difficult, and bleeding is sometimes massive. It can be life-threatening if not clearly diagnosed and treated promptly. Unlike the treatment of gastric and esophageal varices, there is currently no definitive recomended treatment due to insufficient data and rarity. In this article, we report the case of a 78-year-old woman with liver cirrhosis and rectal variceal bleeding which was refractory to medical and endoscopic therapy and successfully treated with transjugular intrahepatic portosystemic shunting (TIPS).
Prognostic value of echocardiographic determination of myocardial dysfunction in acute pancreatitis
Authors:   Ulyanovsk State University, Ulyanovsk, Midlenko O.V. ,   Ulyanovsk Regional Clinical Center for Specialized Types of Medical Care named after E.M. Chuchkalova», Ulyanovsk, Chavga A.I. ,   Ulyanovsk State University, Ulyanovsk,   Ulyanovsk Regional Clinical Center for Specialized Types of Medical Care named after E.M. Chuchkalova», Ulyanovsk, Midlenko V.I. ,   Ulyanovsk State University, Ulyanovsk,   Ulyanovsk Regional Clinical Center for Specialized Types of Medical Care named after E.M. Chuchkalova», Ulyanovsk, Ruzov V.I. ,   Ulyanovsk State University, Ulyanovsk, Belonogov N.I. ,   Ulyanovsk State University, Ulyanovsk
Published: November 2024

Rationale: Echocardiographic changes are observed in more than 50% of patients with acute pancreatitis. Studying the phenomenon of cardiodepression in patients with acute pancreatitis will make it possible to predict the development of moderate and severe pancreatitis. Purpose of the study: to identify the characteristic echocardiographic signs of cardiac dysfunction and their relationship with the severity of acute pancreatitis. Material and methods of research: 81 people participated in the research. Of these, there were 21 healthy volunteers and 60 patients with acute pancreatitis. There were 36 men and 24 women. The results of their own research: having studied the end diastolic volume of the left ventricle (EDV), the authors came to the conclusion that a very large spread of values even in healthy individuals does not allow using this indicator to assess the state of the myocardium. And even more so forecasting. It became obvious that for greater objectification it is necessary to take into account, first of all, the size of the heart. To simplify the calculations, as an indicator indirectly characterizing the size of the heart, the authors decided to use the thickness of the interventricular septum in diastole (IVD). Thus, having EDV and IVS, the authors proposed to use the diastolic coefficient (DK) = EDV / IVS. After analyzing the value of this indicator, the authors found that most often in moderate and severe pancreatitis, established for a completed case, DC was below 9. The diastolic coefficient of DC proposed by the authors, calculated on the first day of treatment, also showed a clear relationship with the severity of pancreatitis, established by the completed case. Conclusions: if, in the absence of hypovolemia and signs of heart failure in patients with acute pancreatitis on the first day of adequate treatment, the value of the diastolic ratio is less than 9, the relative risk of developing moderate and severe pancreatitis is 5.991 at S - 0.359. The diastolic ratio proposed by the authors is a prognostically significant indicator for the development of moderate and severe pancreatitis. The sensitivity of the proposed prediction method is 0.788, the specificity is 0.896.
Blood transfusion to the wounded during the explosion in the Republic of Dagestan
Authors:   Republican blood transfusion station, Makhachkala, Tankaeva H.S. , Pohabov D.S. ,   Pirogov National Medical and Surgical Center, Moscow, Abdulaev I.A. ,   Republican blood transfusion station, Makhachkala, Khavaeva M.G. ,   Republican blood transfusion station, Makhachkala, Alibatyrova R.G. ,   Republican blood transfusion station, Makhachkala, Kuracheva M.M. ,   Republican blood transfusion station, Makhachkala, Zhiburt E.B. ,   Pirogov National Medical and Surgical Center, Moscow
Published: November 2024

Background: on August 14, 2023, as a result of an explosion at a service station in the Kumtorkalinsky district of the Republic of Dagestan, 119 people were injured, 35 of them died, including 3 children. Purpose: to assesse the transfusion of blood components to the victims, the adequacy of the stocks and actions of the blood service, as well as donor practices before and after the disaster. Methods: we studied the work of the blood service and transfusion care in medical organizations of the Republic of Dagestan after an explosion at a service station in the Kumtorkala region. Results: 74 patients were hospitalized, there were no deaths. Blood components were received by 14 (17.7%) patients. The ratio of transfused units of erythrocytes and plasma was 0.37 or 1:2.7. On the first day, 56.3% of erythrocyte units and 65.1% of plasma units were transfused. On average, 1 recipient received 1.1 units of erythrocytes and 3.1 units of plasma. Similar indicators per 1 hospitalized patient were 0.2 and 0.5 doses, respectively. The transfusion therapy of the victims of the tragedy required the use of 2.6% of the stock of erythrocytes and 1.9% of the stock of plasma. During the working week, the number of donations at the Republican Blood Transfusion Station (RSPK) increased by 128%, and at the Kuraev Children’s Republican Clinical Hospital – by 73%. Conclusion: the work of the RSPK and the blood services of the hospitals of the Republic of Dagestan made it possible to provide adequate transfusion assistance to the victims of the explosion.
EDOF – HOW DOES IT WORK?
Authors: Bezik S. V. , Kliimenko A. V. , Chukalina I. V.
Published: November 2024

EDOF is the name of a new category of intraocular lenses that are a kind of compromise between traditional monofocal and trifocal IOLs. Monofocal IOLs allow you to have good vision at one distance with high quality. Multifocal, on the contrary, give sufficient visual acuity at various distances, but are characterized by the presence of a large number of dysphotopsias. Intraocular lenses with extended focus provide greater independence from glasses than monofocals while maintaining high quality vision.

Objective: to discuss the available information on the principles of EDOF imaging by lenses and the dependence of the state of the wavefront of the artiphakic eye on the combination of spherical corneal aberrations and IOLs.

The wavefront of the eye is formed by several structural elements, the main of which are the cornea and the lens (artificial lens). The study of aberrations of the human eye is in the field of refractive surgery. Attempts to use aberrations in cataract surgery began with the creation of aspherical IOLs. The latter were intended to correct spherical corneal aberrations and were aimed at improving the characteristics of the wavefront. The development and use of aspherical IOLs were based on data on the state of the cornea of the average eye and gave a conditional effect. The new generation of IOLs based on the creation of a certain number and type of spherical aberrations is designed to modify (deform) the wavefront of the artifakic eye and expand its optical capabilities while maintaining a low number of dysphotopsias. This, in a way, revolutionary change in trends brings cataract surgery even closer to refractive surgery.

According to the authors, for the fullest use of the capabilities of IOLs from the EDOF category, it is necessary to apply the principles and experience of refractive surgery in terms of studying the characteristics of the operated eye and correlating them with the parameters planned for IOL implantation.