bluuebunny/crossref_metadata_2025 huggingface dataset:
CONSUMER CHOICE AND EVALUATIONS: THE IMPACT OF VALUE CONSCIOUSNESS ON TRUST AND STORE SATISFACTION
Authors: SAHIN Aysun
Published: August 2022

A major priority for retailers, it is important to explore the relationships between customers’ value
consciousness, trust, and satisfaction. This research explores the relationships among customers’ value
consciousness, trust, and satisfaction using a field dataset for hard discounter grocery chains Turkey. The
data gathered from consumers was investigated by using partial least squares (PLS) and the SmartPLS
(v.3.3.9). The findings demonstrate that value concioussness directly and positively effects trust and
satisfaction of consumers. Also trust directly and positively effects store satisfaction of consumers in hard
discounter grocery retail domain.
THE ELASTICITY OF EXPORTING THE MINING QUARRYING PRODUCTS TO FOREIGN EXCHANGE RATE CHANGES
Authors: SOYLEYICI Gulin Tugce , KALKAN Adnan , GUNAY Abdullah
Published: August 2022

Elasticity examining the exporting the products to foreign exchange rates, has been subject to so many
studies. Exports are expected to increase in the case of the depreciation of the domestic currency in the
economies where exports and imports are sensitive to foreign exchange rate. While foreign currency
appreciation increases the profitability of the firms also increases because their costs are in domestic
currency. This paper investigates how exchange rate changes affect mining & quarrying exports in
Turkey. In this paper we aim to identify the elasticity of mining & quarrying exports to dollar exchange
rate changes. Mining & quarrying whose development are mostly dependent on nature sector exports
which is predominantly sensitive to the dollar exchange rate, was tried to be analysed by using the least
squares method. Data representing the exchange rate for monthly average dollar-selling prices between
the years of 2005-2017, obtained from the data system of the TCMB (The Central Bank of the Republic of
Turkey) is used. In addition this, export data denominated in dollars for mining & quarrying products for
the same period, were also obtained from the TUIK (Turkish Statistical Institute). Data obtained from
those for 156 periods were analysed through the SPSS statistical packaged software program. As a result,
mining & quarry exports are sensitive to the dollar exchange rate and a 1% increase in dollar exchange
rate increases mining & quarrying exports by approximately $ 8,8 million. Besides this result, a one
percent (1%) standard deviation increase in dollar exchange rate leads to a 0.65 standard deviation
increase in exports of mining & quarrying products. These findings are consistent with the literature on
elasticity to foreign exchange rate changes.
Profile of Tuberculosis in Children and Adolescent at Dr. Soetomo General Hospital Surabaya
Authors: Firnadi Litiya Parahita Putri , Setyoningrum Retno Asih , Suwandi Mohammad Yamin Sunaryo
Published: August 2022

Introduction: Tuberculosis is one of ten leading causes of death worldwide, including Indonesia. Indonesia is one of seven countries that causes 64% deaths due to tuberculosis. Tuberculosis is caused by Mycobacterium tuberculosis through droplet nuclei in the air. It can occur to any group age, including children and adolescent, if there is a contact history of people with tuberculosis infection. In 2016, one million children had tuberculosis and around 250,000 children died because of tuberculosis. This study aimed to know the profile of tuberculosis in children and adolescent at Dr. Soetomo General Hospital Surabaya.Methods: This was a descriptive study using retrospective approach. Sample of this study was collected from electronic medical record provided by Dr. Soetomo General Hospital Surabaya using statistic formula of single sample for estimated population proportions of children and adolescent with tuberculosis from 2013-2017, with total samples of 149 people.Results: There were 149 samples of children and adolescent patients with tuberculosis. Most of the children were mostly 0-4 years old and 57% were female. 84% of the children had been immunized with BCG and classified as moderate, and 35% were under nutritional status. This study showed that 67% of the children in household contacts of adult tuberculosis patients also had tuberculosis. The most frequent symptoms of tuberculosis in children and adolescent were fever (72%) and cough (80%).Conclusion: Tuberculosis in children and adolescent is more likely to occur in children than adolescent, especially children within group age of 0-4 years old. The number of pulmonary tuberculosis in children and adolescent are higher than extrapulmonary tuberculosis.
Decubitus Ulcer Patients Profile in Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018
Authors: Permatasari Azmil , Hutagalung Magda Rosalina , Sulistiawaty Nuniek Nugraheni , Budi Agus Susanto
Published: August 2022

Highlights:1. Decubitus ulcers can be caused by prolonged immobilization and constant pressure on the body.2. Decubitus ulcer patients were dominated by females, aged 46-65 years old, and the most common comorbidity history was patients with limb weakness.
AbstractIntroduction: Continuous pressure on the area of the skin, especially in areas with bone protrusion can cause decubitus ulcers. Decubitus ulcers can occur to anyone, both children and adults, male or female, especially in people who experience daily immobility in a bed or wheelchair. Many treatments are performed in order to prevent decubitus ulcers to not becoming a more dangerous condition. This study aimed to determine the profile of pressure ulcers in Dr. Soetomo General Hospital Surabaya.Methods: This was a cross-sectional descriptive retrospective study. Secondary data were collected from 25 medical records of pressure ulcer patients in the Outpatient Clinic Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018. The data such as age, gender, risk factors, comorbidities history, and management were taken. The calculation was performed using Microsoft Excel.Results: The majority of patients with pressure sores at the Outpatient Clinic Department of Plastic Surgery Dr. Soetomo General Hospital Surabaya from January to December 2018 were dominated by female patients aged 46-65 years old (24%), with the most common risk factor being immobilization (96%). Patients’ history showed that most patients with decubitus ulcers suffered from a weakness in the limbs (13%). The most common treatment was wound bed preparation (46%) and education (46%).Conclusion: Pressure ulcers most often occurred in women aged 41-65 years or the elderly. Most patients experienced immobilization as a risk factor for pressure ulcers. These patients were dominated by those who had a history of illness with limb weakness. The therapy applied to patients with pressure sores was the preparation of wound beds and education to the patient.
Sedentary Lifestyle and Overweight in Relation to the Risk of Polycystic Ovary Syndrome in Senior High School Students in Surabaya
Authors: Putri Shafira Noorania , Santoso Budi , Budiono Budiono
Published: August 2022

Highlights:1. Most senior high school students live a sedentary lifestyle.2. Hyperinsulinemia and hyperandrogenism were related to an increased risk of PCOS in adolescents.3. Sedentary lifestyle and overweight were found to have a significant correlation with increased risk of PCOS in adolescents.
AbstractIntroduction: Adolescent polycystic ovary syndrome (PCOS) is one of the endocrine and metabolic disorders characterized by oligomenorrhea and hyperandrogenism. A sedentary lifestyle in adolescence increases the risk of overweight and obesity. Being overweight may increase the risk of PCOS in adolescents by the mechanism of insulin resistance and hyperinsulinemia, which affects the function of adrenal and ovarium androgen production. The increase of androgen has an important effect on PCOS. This study aimed to examine the relationship between a sedentary lifestyle and being overweight as the risk of PCOS in adolescents.Methods: This was an observational analytic study with a cross-sectional design. This study was held at State Senior High School (SMAN) 5 Surabaya from February to April 2020. The sample of this research was chosen by random sampling of all female students in SMAN 5 Surabaya. The data were collected by direct measurement of student’s weight and height and a questionnaire consisting of Global Physical Activities Questionnaire, menstrual cycle, and Ferriman–Gallwey score. The students were stated at risk of PCOS if they had an abnormal uterine bleeding pattern and had Ferriman–Gallwey score ≥5. The data were analyzed using logistic regression analysis.Results: Of 82 students (100%), 32 students were overweight (39%), 5 students had obesity (6.1%), 44 students were performing a sedentary lifestyle (53.7%), 42 students had Ferriman–Gallwey score ≥5 (51.2%), 38 students had an abnormal uterine bleeding pattern (43.3%), and 35 students were at risk of PCOS (42.6%). Logistic regression analysis showed there was a significant relationship between a sedentary lifestyle and the risk of PCOS (p = 0.004) and a significant relationship between being overweight and the risk of PCOS (p < 0.001). People with a sedentary lifestyle have 6.3 folds higher risk of PCOS than normal people, and people with overweight have 16.2 folds higher risk of PCOS than normal people.Conclusion: Sedentary lifestyle and overweight have the role of increasing the risk of PCOS in adolescents.
Incidence of Respiratory Tract Infection in Children with Cyanotic and Acyanotic Congenital Heart Disease: A Comparative Study
Authors: Yasmine Syafira , Utamayasa I Ketut Alit , Herwanto Bambang
Published: August 2022

Highlights:1. The incidence of respiratory tract infection (RTI) showed no difference between patients with cyanotic and acyanotic congenital heart disease (CHD).2. RTI patients with acyanotic CHD experienced longer hospital lengths of stay.
AbstractIntroduction: Respiratory tract infection (RTI) is the leading cause of children mortality rate in the world. Congenital heart disease (CHD) is a common congenital disease that plays a role in RTI incidents. However, between the 2 types of CHD, which type that is more potential to cause the RTI is not well identified. The aim of this study was to compare the incidence and hospitalization time of RTI between 2 types of CHD and describe the profile of the patients based on gender, age, nutrition, and immunization status.Methods: This retrospective study identified the medical records of children with RTI and all types of CHD aged 0-18 years old at Dr. Soetomo General Hospital Surabaya. The diagnosis of CHD was observed by echocardiography and RTI was observed by clinical symptoms.Results: Of 135 patients, the incidence of RTI showed no difference between a patient with cyanotic and acyanotic CHD. The majority of the patient was aged less than 3 years old (93.3%) and dominated by male patients (53.3%). The frequency of children with severe underweight and good nutritional status was equal. There were 85 patients who had incomplete immunization based on their age. The most common type of acyanotic CHD was an atrial septal defect (ASD). Cyanotic CHD was dominated by the tetralogy of Fallot (ToF). Pneumonia was the common type of RTI (108/135). RTI patients with acyanotic CHD had a longer time of hospitalization than cyanotic patients (11 days).Conclusion: This study found that RTI patients with acyanotic CHD experienced longer hospital lengths of stay.
Therapeutic Communications of Doctors and Hypertensive Patients’ Satisfaction
Authors: Prasasta Reka Elvia Dirda , Dewanti Linda , Husada Dominicus , Djuari Lilik
Published: August 2022

Highlights:1. Doctors who perform therapeutic communication make patients more satisfied with their services.2. Good therapeutic communication is the most effective way to establish relationships with patients with long-term treatment such as hypertension.
AbstractIntroduction: Hypertension or high blood pressure is an increase in systolic blood pressure of more than 140 mmHg and diastolic blood pressure of more than 90 mmHg at two measurements at intervals of five minutes under adequate rest/calm conditions. Therapeutic communication is the most effective and important thing in establishing relationships between doctors and patients. Good communication based on trust will produce satisfaction from the patients, thus they can seek treatment again. This study aimed to analyze the relationship between therapeutic communication and hypertensive patients’ satisfaction measured among those who visited the Primary Health Center (PHC) of Surabaya to control their blood pressure.Methods: This was a cross-sectional quantitative study with all hypertensive patients who visited the PHC in November 2018-January 2019 as the subjects. Characteristics of the subjects, as well as the doctors and the therapeutic communication practices, were rated by the patients. Patients’ satisfaction was collected using validated questionnaires.Results: According to a relationship analysis between doctors’ therapeutic communication and patients’ satisfaction, it is found that there was a significant relationship. This was based on a significance value of 0.00 and smaller than 0.05. The better the communication applied by the doctor, the more satisfied the patient was. This study showed that service satisfaction was influenced by therapeutic communication where doctors at the PHC try to fulfill every indicator.Conclusion: There was a relationship between the therapeutic communication of doctors and the satisfaction of hypertensive patients at the PHC.
Wound Pattern Profile in Deceased Victims of Traffic Accidents in Raden Said Sukanto Bhayangkara Hospital Jakarta from January 2017 until December 2018
Authors: Dewanto Evan Boedi , Yudianto Ahmad , Hutagalung Magda Rosalina
Published: August 2022

Highlights:1. Traffic accidents can cause different types of wounds.2. Traffic accident victims were predominantly male at the age of 26-45 years old. 3. The most found wounds were abrasions and the most affected area were head and neck.
AbstractIntroduction: A traffic accident is an incident that happens on the road, such as a car crash that started on the road and leads to injury or death or damaged properties in the surrounding environment. Traffic accident injuries have a different pattern from any other events or violence, such as a mechanical injury due to friction with asphalt. The wounds that are usually found on the victims are abrasion, laceration, contusion, and wounds with fracture. About 70% of traffic accidents in Indonesia are happening in Java. The aim of this study was to determine the wound patterns of victims of traffic accidents, particularly deceased victims recorded in the Forensic Department of Raden Said Sukanto Bhayangkara Hospital Jakarta from January 2017 until December 2018.Methods: This was a descriptive study using secondary data. Consecutive sampling methods were used by using an external examination form obtained from the Forensic Department of Raden Said Sukanto Bhayangkara Hospital Jakarta from January 2017 until December 2018. Age, gender, and wound patterns such as abrasion, laceration, contusion, and wounds with fracture data were taken.Results: 67 cases of traffic accidents were recorded. Male victims were the most common victims (87.5%) within the age of 26–45 years old (42.18%). Abrasions were the most common wounds found (44.92%) and head and neck region were the most affected area (44.09%).Conclusion: The deceased victims of traffic accidents were mostly males aged 26–45 years old. The most common wound found were abrasions and the most affected areas were head and neck region.
Cranium morphometry for distinguishing male and female Muscovy duck (Cairina moschata) before sexual maturity
Authors: Mafatichul Firdaus  , Abdul Samik  , Yeni Dhamayanti  , Raden Tatang Santanu Adikara  , Hana Eliyani  , Soeharsono Soeharsono
Published: August 2022

Gender determination of Muscovy duck as early as possible is essential for the efficiency and effectiveness of duck production. This study aimed to determine the morphometric differences in prepubertal male and female Muscovy duck (Cairina moschata) as predictors of gender. This study used a split-plot design, with the observed variables cranium length, width and height, mandibular length, and rostrum length and width. This study used a total of 80 samples of duck heads consisting of 40 male and 40 female Muscovy duck heads, with ten heads each in the age group of 2, 4, 6, and 8 weeks, respectively. Results showed that the length, width, and height of the cranium, mandibular length, and rostrum lengthand width were greater in males (p <0.05) than those of the females in all age groups. It could be concluded that the morphometric size of prepubertal male Muscovy ducks head was greater than those of the female ones at the same age; thereby, it could be used to distinguish gender. Based on the morphometrics, further study can also be conducted to measure other body parts of the Muscovy duck apart from the cranium. In addition, it is necessary to study the morphometric measurements of the cranium in other poultry as a basis for identifying sex.
Determination of estrus duration based on cervical mucus characteristics in Aceh cattle using camera-equipped artificial insemination endoscope
Authors: Drh., M.Sc Ginta Riady , Dian Mulfristia  , Hendra Saputra  , Cut Nila Thasmi  , Hafizuddin Hafizuddin  , Mudhita Zikkrullah Ritonga  , Rosmaidar Rosmaidar
Published: August 2022

This study aimed to determine the length of the estrus period in Aceh cows based on changes in the characteristics of cervical mucus observed using a camera-equipped artificial insemination (AI) endoscope. This study used twelve healthy and reproductively sound cows aged 4-6 years. All cows were synchronized using prostaglandin F2α (PGF2α) injected intramuscularly twice, 11 days apart. Estrus detection was conducted 24 hours following the second injection of PGF2α three times daily for 30 minutes, respectively. Estrous cows were then subjected to the examination of their cervical mucus at 0, 6, 12, and 18 hours after the beginning of estrus. This study showed that out of 12 samples, only eight cows exhibited estrus signs. Characteristics of cervical mucus of cows at 0 and 6 hours of estrus were transparent. At 12 hours of estrus, five cows showed transparency, and the remaining three cows showed cloudy cervical mucus. Meanwhile, at 18 hours of estrus, all sampled cows showed cloudy cervical mucus then regarded as the end of the estrus. That means the estrus length of Aceh cows in this study was 15.75 ± 3.11 hours. It can be concluded that the determination of the duration of estrus in Aceh cows based on changes in the characteristics of the cervical mucus can be carried out using an AI endoscope with a camera. For further research, it is suggested to apply this estrus detection technique in the implementation of AI and determine the pregnancy rate.
Effect of taurine on histopathological features of spermatogenesis in seminiferous tubules of mice (Mus musculus) induced by paraquat
Authors: Rahadi Yustisiane Ruth , Tri Wahyu Suprayogi  , Rahmi Sugihartuti  , Kadek Rachmawati  , Hani Plumeriastuti
Published: August 2022

This study aimed to determine the effect of taurine on the enhancement of the spermatogenetic process in male mice (Mus musculus) induced by paraquat (PQ). Twenty-five male mice (Mus musculus) aged 2-3 months with a bodyweight of around 35 grams were divided randomly into five groups. The K + and the treatment group (P1, P2, and P3) mice were induced using PQ. PQ was given intraperitoneally (IP) twice a week for 21 consecutive days at a dose of 30 mg/kg BW. Two hours after the administration of PQ, P1, P2, and P3 groups were given taurine at a dose of 250, 500, and 1000 mg/kg BW/day for three weeks (Heidari et al., 2019). K- group was given distilled water (IP) only. On day-29, mice were sacrificed for testicles histopathological preparations with hematoxylin-eosin staining. Results showed that the mice exposed to PQ only (the K+ group) had a reduced spermatogenesis score compared to those of the K- group (p <0.05).  Taurine treatment on PQ-exposed mice was followed by an increase spermatogenesis score. The optimal curative dose of taurine was 500 mg/kg (P2 group). However, a higher dose (1000 mg/kg BW) of taurine resulted in a decline in the spermatogenesis score than those of at the 500 mg/kg. It could be concluded that treatment with taurine could enhance the spermatogenetic process of male mice (Mus musculus) induced by PQ.
Partial albinism in Hawksbill turtle (Eretmochelys imbricata) in Rio Grande do Norte, Brazil
Authors: Rocha Emanuel Lucas , Pinheiro da Silva Lucas Gabriel Verissimo , Rocha Barreto Isadora Nathalia , De Araújo Júnior Hélio Noberto , Navoni Julio Alejandro , De Oliveira Moacir Franco , Bezerra de Moura Carlos Eduardo
Published: August 2022

Albinism is a genetic disorder in which there is a defect in melanin production, a pigment which gives color to the skin, hair and eyes. This congenital malformation can also occur in sea turtles, although it is not fatal, but it reduces their chances of survival in the natural environment. Even so, there are still no reports of its occurrence in Eretmochelys imbricata, a species known as the hawksbill turtle or legitimate turtle, with wide distribution in tropical seas. The present study describes the case of an individual with partial albinism in the E. imbricata species, found on the northern coast of Rio Grande do Norte, Brazil. The animals were collected at Cabo de São Roque beach in January 2020 during the reproductive season of the species. After analyzing the animal, it can be classified as having partial piebald albinism, since it still has lighter spots both on the skin and in the carapace and plastron regions.
Bulldog calf born to Limousin-Peranakan-Ongole crossbred cow after insemination with Simmental bull semen
Authors: Yuriati
Published: August 2022

This case describes a bulldog calf born to Limousin-Peranakan-Ongole (LimPO) crossbred cow after insemination with frozen-thawed Simmental bull semen. The dam was a four year old LimPO crossbred cow, with a bodyweight of 380 kg; she was 8.5 months pregnant and has never had any reproductive disorders before. Signs of impending calving appeared at 6 am, and the discharge was normal, but until noon the calf had not been born. Body temperature was 38°C, while other vital signs were normal. Vaginal exploration revealed a completely opened cervix, and the calf was alive, in posterior longitudinal presentation with palpable short hindlegs. The calf was delivered per vaginam with traction. The calf was male with a weight of 15 kg, and was alive, but after a few minutes, the calf died. The monstrous calf was found with morphological defects including a smaller compressed body, head resembled those of a bulldog with a short muzzle and an undershot jaw, shortened fore- and hindlegs, and ascites abdomen. The dam was given 70, 000 IU procaine penicillin G and 70 mg dihydrostreptomycin sulphate (Penstrep-400, Interchemie, Holland), 0,3 g diphenhydramine HCl (Vetadryl, Sanbe, Indonesia), 10 mg vitamin B12 (Jectavit B12, Sanbe, Indonesia) by intramuscular injection. The dam looked healthy, and had normal appetite after the delivery assistance.
The Innovation of Waqf Andragogy Amidst ‘Kampus Merdeka’ Era
Authors: Sulistyowati  , Possumah Bayu Taufik , Nurul Huda  , Siti Nur Indah Rofiqoh  , Zulfison
Published: August 2022

Waqf, as a unique Islamic legacy, has been practiced since the Prophets Muhammad Era. Unfortunately, society’s understanding of waqf is not yet comprehensive and accurate, mainly at the higher education level. The study aims to provide the innovative andragogical formulation for higher education institutions regarding the ‘Kampus Merdeka’ enforcement and to explore the breakthroughs in waqf curriculum by academicians in universities during the KKM era. Focused Group Discussion (FGD) and semi-structured in-depth interviews are conducted to gather the primary data from the relevant respondents such as regulators, academicians, practitioners, and students. Initially, the desk study is used as a literature review from various sources to obtain prior knowledge related to the topic investigated. Findings of this study have revealed that Waqf stakeholders identified several innovative methods in the form of creative implementation such as Reshaping of National Standard Waqf Curriculum, Link and Match of Waqf Education with the Waqf DUDI, Waqf Literacy Relevant Movement, and IT and Waqf Digital Engagement. Thus, this study recommends a point regarding its result that some challenges have to be tackled altogether by the stakeholders in terms of educator capacity and the lack of human resources from the practitioner to undertake massive socialization with the adult learner. This research result could be implemented in the higher education institution that teaches waqf and other instruments of Islamic Social Finance (ISF) as one of the subjects in the Islamic Economic curriculum.
Efektifitas Penggunaan Digital Game Base Learning Menggunakan Aplikasi Spritebox untuk Meningkatkan Motivasi dan Hasil Belajar Mahasiswa
Authors: Salkha Novita , Wihidayat Endar Suprih , Hatta Puspanda
Published: August 2022

Purpose of this study to determine the effect of using SpriteBox educational game applications on student motivation and learning outcomes in basic programming subjects, especially looping material. This research was conducted at JPTK UNS Informatics Engineering Education Study Program. The research method used quantitative research with a pre-experimental design One Group Pretest-Posttest. The population was all students of PTIK UNS class of 2020 which consisted of 76 students. All the members the of the population are sampled, so the sampling technique used total sampling. Data collection techniques used questionnaires and tests. Questionnaires and tests were piloted first and then tested for validity and tested for reliability. The data analysis technique used the t test (difference test) after previously was tested by normality and homogeneity. The results showed that: 1) Learning-based SpriteBox game media had an effect on students' learning motivation. Proved by the difference significantly on learning motivation before and after experimentation. There was an increased average learning motivation after using SpriteBox game; 2) Learning-based SpriteBox game media affected students’ learning outcomes. Proved by the difference significantly on learning outcomes between before and after experimentation. There was an increased average learning outcome after using SpriteBox game.
US Black–White Differences in Mortality Risk Among Transgender and Cisgender People in Private Insurance, 2011–2019
Authors: Hughes Landon D. , King Wesley M. , Gamarel Kristi E. , Geronimus Arline T. , Panagiotou Orestis A. , Hughto Jaclyn M. W.
Published: August 2022

Objectives. To compare survival by gender and race among transgender and cisgender people enrolled in private insurance in the United States between 2011 and 2019.

Methods. We examined Optum’s Clinformatics Data Mart Database. We identified transgender enrollees using claims related to gender-affirming care. Our analytic sample included those we identified as transgender and a 10% random sample of cisgender enrollees. We limited our sample to those 18 years or older who were non-Hispanic Black or White. We identified 18 033 transgender and more than 4 million cisgender enrollees. We fit Kaplan–Meier survival curves and calculated standardized mortality ratios while adjusting for census region.

Results. Black transfeminine and nonbinary people assigned male sex at birth were 2.73 times more likely to die than other Black transgender people and 2.38 and 3.34 times more likely than Black cisgender men and women, respectively; similar results were found when White transfeminine and nonbinary people assigned male sex at birth were compared with White cisgender cohorts.

Conclusions. Our findings highlight glaring inequities in mortality risks among Black transfeminine and nonbinary people assigned male sex at birth and underscore the need to monitor mortality risks in transgender populations and address the social conditions that increase these risks. (Am J Public Health. 2022;112(10):1507–1514. https://doi.org/10.2105/AJPH.2022.306963 )
Outcomes of Intramedullary Nailing and External Fixation of Open Tibial Fractures
Authors: Cortez Abigail , Urva Mayur , Haonga Billy , Donnelley Claire A. , von Kaeppler Ericka P. , Roberts Heather J. , Shearer David W. , Morshed Saam
Published: August 2022

Background:

While surgeons in low and middle-income countries have increasing experience with intramedullary nailing (IMN), external fixation (EF) continues to be commonly used for the management of open tibial fractures. We examined outcomes with extended follow-up of the participants enrolled in a clinical trial comparing these treatments.

Methods:

Adults who were ≥18 years old with acute AO/OTA type-42 open tibial shaft fractures were randomly assigned to statically locked, hand-reamed IMN or uniplanar EF. These participants were reevaluated 3 to 5 years after treatment. The primary outcome was death or reoperation for the treatment of deep infection, nonunion, or malalignment. Unresolved complications such as persistent fracture-related infection, nonunion, or malalignment were collected and analyzed. Secondary outcomes included the EuroQol-5 Dimension-3 Level (EQ-5D-3L) questionnaire, the Function IndeX for Trauma (FIX-IT) score, radiographic alignment, and the modified Radiographic Union Scale for Tibial fractures (mRUST).

Results:

Of the originally enrolled 240 participants,126 (67 managed with IMN and 59 managed with EF) died or returned for follow-up at a mean of 4.0 years (range, 2.9 to 5.2 years). Thirty-two composite primary events occurred, with rates of 23.9% and 27.1% in the IMN and EF groups, respectively. Six of these events (3 in the IMN group and 3 in the EF group) were newly detected after the original 1-year follow-up. Unresolved complications in the form of chronic fracture-related infection or nonunion were present at long-term follow-up in 25% of the participants who sustained a primary event. The EQ-5D-3L index scores were similar between the 2 groups and only returned to preinjury levels after 1 year among patients without complications or those whose complications resolved.

Conclusions:

This observational study extended follow-up for a clinical trial assessing IMN versus EF for the treatment of open tibial fractures in sub-Saharan Africa. At a mean of 4 years after injury, fracture-related infection and nonunion became chronic conditions in nearly a quarter of the participants who experienced these complications, regardless of reintervention.

Level of Evidence:

Therapeutic Level IV. See Instructions for Authors for a complete description of levels of evidence.
TÜBİTAK Projelerindeki Güçlü Araştırma İşbirliğinin Sosyal Ağ Analizi ile Dinamiklerinin Değerlendirilmesi
Authors: UNUTULMAZ Sevim
Published: August 2022

İşbirliği ağları, araştırmacıların bilimsel işbirliğini gösteren düğümlerden ve çok sayıda bağlantıdan oluşmaktadır. Bu ağları sosyal ağ analizi yöntemi ile incelemek mümkündür. Bu makalenin amacı, Türkiye’deki üniversiteler tarafından yürütülen TÜBİTAK 1001 projeleri kapsamında ortak işbirliğine dayalı oluşturulan üniversiteler arası işbirliği ağlarının görselleştirmesi ve önemli pozisyonda yer alan üniversitelerin tespit edilmesidir. Bu bağlamda TÜBİTAK 1001 proje işbirliklerinin mevcut durumuna ışık tutmak amaçlanmıştır. Çalışmanın örneklemi 2012-2020 yılları arasında yürütülen 2323 adet TÜBİTAK 1001 projesinden oluşmaktadır. Ağın genel yapısı ise toplam 193 üniversite (düğüm) ve 2805 ortak işbirliğini (bağlantı) kapsamaktadır. Her düğüm TÜBİTAK 1001 proje işbirliği ağındaki bir üniversiteyi temsil ederken toplam araştırmacı sayısı 8.205 kişiden oluşmaktadır. Bilimsel işbirliği UCINET 6.732 ve NetDraw 2.168 yazılımı kullanılarak sosyal ağ analizi yöntemi ile analiz edilmiştir. Bu kapsamda öncelikle TÜBİTAK 1001 projeleri ve işbirlikleri hakkında genel bilgilere yer verilmiştir. Ardından en çok işbirliği yapılan üniversiteler ve en güçlü üniversite işbirlikleri tespit edilmiştir. Daha sonrasında ise TÜBİTAK 1001 proje işbirliğini incelemek için merkezilik analizi gibi çeşitli sosyal ağ analizi (SNA) yöntemleri kullanılmıştır. İşbirliklerin sosyal ağlardaki durumunu yansıtan merkezilik hesaplamaları, ağ analizinde en önemli ölçütlerden biridir. Uygulanan analizler sonucunda üniversitelerin ağdaki performans ve rollerini değerlendirmeye yönelik faydalı bilgiler elde edilmiştir.
Analysis of the Effect of Religiosity on Subjective Well-Being
Authors: AKYÜREK Zeynep
Published: August 2022

The study aims to investigate how religiosity and demographic variables affect the components of life satisfaction (cognitive subjective well-being) and happiness (emotional well-being) which constitute subjective well-being. Data obtained from the World Values Survey is used in the study and the estimates are made by using sequential logit regression method. In the study, "religiosity" which is accepted as a variable expressing subjective well-being is preferred to be used as a holistic concept that is effective on the social and spiritual life of the individuals rather than using it as a general concept. In this context, religiosity is discussed in three different components; social integration, divine interaction, and existential certainty. One of the most crucial findings of the study is that life satisfaction and happiness is affected by the components of religiosity in different manners. Although there is a positive relationship between religiosity and subjective well-being, questioning the social maladjustment (drugs, tobacco, crime, etc.) encountered in more religious regions constitutes the starting point of the study.
Comparative Results for ESP Applications in Gassy Wells when Using Single Gas Handling Systems vs. Multiple Gas Handling Systems for Pioneer Natural Resources
Authors: Martinez Villarreal Paola Elizabeth , Escobar Patron Ana Katherine , Rosales Ballesteros Eder Jean , Schreck Stephen
Published: August 2022

Electric submersible pumps (ESPs) have historically been limited when operating in gassy conditions. Studies and evidence gathered during failure analysis confirm the effects of gas on the performance of ESPs. Gas locking, mechanical wear, and low efficiency due to challenging environments have made operators change from a standardized string to a string that can mitigate the effects of gas, which can help maximize the production and increase the pump's run life.

The impellers of the centrifugal pump require a minimum amount of liquid mass in the impeller vanes to transfer the kinetic energy to the fluid mixture. This energy will be transformed to potential energy in the diffuser, but if the mass mixture in the impeller cannot perform an efficient energy transfer for the mixture, only the liquid phase will be pushed out the vanes of the pump and most of the gas will stay behind, filling the vanes of the impeller and creating a gas-lock condition.

In environments with a high presence of gas, additional equipment such as rotary gas separators are used to remove as much gas as possible before the fluids enter the pump. Gas separators have been proved as effective. However, when the conditions are extreme, such as in unconventional reservoirs, additional devices will be required to maintain a stable operation of the ESP, pump as much as possible a homogenous fluid, and minimize the downtime due to unnecessary trips to maximize the overall performance and run life of the ESP system, and optimize production and total cost of ownership for artificial lift operations.

This paper presents the comparative results of the performance of a group of ESPs installed in unconventional wells of a leading Midland basin operator with challenging conditions to operate an ESP. It will analyze the performance of the ESPs and compare the trends of the downhole parameters while operating with a standard string with a single gas separator and gas-handling system with those of an upgraded string that includes a tandem gas separator, an advanced gas-handling system, and a multiphase gas-handling system equipped with helico-axial-flow stages. This change in designs and configuration has improved the run life of the ESPs for unconventional wells with high gas volume fractions.
A modified candy-plug technique to occlude false lumen in aortic dissection
Authors: Palm Erik , Valtola Antti , Manninen Hannu , Saari Petri
Published: August 2022

Purpose: Aim of this technical note article is to introduce a modified, novel way to custom create a candy-plug (CP) device to endovascularly occlude false lumen. The technique is illustrated by a patient case with significant backflow to false lumen (FL). The patient had already undergone surgical repair of the ascending aorta, aortic arch and subsequent TEVAR procedure down to the ostium of the celiac trunk because of type A aortic dissection, but the descending thoracic aorta continued to dilate due to backflow to the FL from an uncovered tear at the level of the renal arteries.Materials and methods: We modified a Gore Excluder 36-45 mm aortic extender (W. L. Gore & Associates, Inc. Flagstaff, USA) endoprosthesis into a CP device that was subsequently positioned under local anesthesia into the FL of the distal descending thoracic aorta.Results: In 1 month control the backflow to false lumen had ceased and the aorta had decreased in diameter from 69 to 66 mm, FL from 37 to 34 mm, true lumen (TL) remained the same 32 mm. Conclusion: We describe a modified, effective candy-plug technique to occlude retrograde false lumen filling in aortic dissection.
“The wrong tools for the right job”: a critical meta-analysis of traditional tests to assess behavioural impacts of early life stress
Authors: Stupart Olivia , Robbins Trevor W , Dalley Jeffrey W
Published: August 2022

Rationale: Unconditioned tasks in rodents have been the mainstay of behavioural assessment for decades, but their validity and sensitivity to detect the behavioural consequences of early life stress (ELS) remains contentious and highly variable. Objectives: In the present study, we carried out a meta-analysis to investigate whether persistent behavioural effects, as assessed using unconditioned procedures in rats, are a reliable consequence of early repeated maternal separation, a commonly used procedure in rodents to study ELS. Methods: A literature search identified 100 studies involving maternally separated rats and the following unconditioned procedures: the elevated plus maze (EPM); open field test (OFT); sucrose preference test (SPT) and forced swim task (FST). Studies were included for analysis if the separation of offspring from the dam was at least 60 min every day during the pre-weaning period prior to the start of adolescence. Results: Our findings show that unconditioned tasks are generally poor at consistently demonstrating differences between control and separated groups with pooled effect sizes that were either small or non-existent (EPM: Hedge’s g= -0.35, p=0.01, OFT: Hedge’s g= -0.32, p=0.05, SPT: Hedge’s g=-0.33, p=0.21, FST: Hedge’s g=0.99, p=0.0001). Despite considerable procedural variability between studies, heterogeneity statistics were low; indicating the lack of standardization in the maternal separation protocol was the not the cause of these inconsistent effects. Conclusions: Our findings indicate that unconditioned tests of depression and anxiety are unreliable for measuring the behavioural sequelae of ELS. We argue that more objective tasks that sensitively detect specific cognitive processes are better suited for translational research on stress-related disorders such as depression.
Effective Remediation of Pb2+ Polluted Environment by Adsorption onto Recyclable Hydroxyl Bearing Covalent Organic Framework
Authors: Elewa Ahmed M. , Mahdy Ahmed F. M. EL , Chou Ho-Hsiu
Published: August 2022

Heavy metal ions removal from wastewater has attracted keen interest due to its toxicity. Adsorption is one of the most promising approaches for heavy metal ions removal owing to its simplicity and effectiveness. Recently, covalent organic frameworks (COFs) have become promising adsorbents for effective wastewater remediation. However, many building blocks have been developed, and the constructing COFs with high adsorption efficiency remains a challenge. Herein, covalent organic framework, DHTP–TPB COF, decorated with hydroxyl groups was designed for the efficiency Pb2+ removal. The DHTP–TPB COF showed excellent performance in adsorbing Pb2+ from aqueous solution. More importantly, DHTP-TPB COF shows a high selectivity for Pb2+ compared to other competing ions, which captured Pb2+ ions with a removal efficiency of over 96% at pH ~ 4. The results show that the DHTP–TPB COF has excellent adsorption capacity at pH 4 up to 154.3 mg/g for Pb2+ ions, the value is comparable with many COFs reported so far. More interestingly, this work provided a correction to the way of the isotherm study that has been frequently followed before. Moreover, the adsorbed Pb2+ ions could be readily eluted using a 0.1M EDTA solution, and the DHTP–TPB COF can be reused for more than five adsorption-elution cycles without any significant adsorption efficiency loss. Furthermore, the adsorption mechanism was revealed using the XPS analysis indicating the formation of strong coordination bonding interactions between hydroxyl and Pb2+. Therefore, the DHTP–TPB COF produced herein has a high potential for treating Pb2+-contaminated wastewater, and it is promising for Pb2+ ion adsorption in practice.
Long term safety and efficacy of corneal cross-linking
in patients affected by keratoconus
Authors: Knutsson Karl Anders , Genovese Paola Noemi , Paganoni Giorgio , Ambrosio Oriella , Ferrari Giulio , Zennato Arianna , Caccia Michela , Cataldo Madeleine , Rama Paolo
Published: August 2022

Background/Objectives:Large retrospective study evaluating the effectiveness and safety of corneal collagen cross-linking (CXL)Subjects/Methods: 886 eyes with progressive keratoconus were enrolled in a retrospective cohort study in a tertiary care university hospital. CXL was performed using a standardised technique (Dresden protocol: 0.1% riboflavin solution containing dextran 20% for 30 minutes during the soaking phase followed by 30 minute ultraviolet A irradiation (3mW/cm2)). Visual outcomes, maximum keratometry (Kmax), demarcation line measurements, and complications were recorded.Results:Uncorrected visual acuity (UCVA) improved from 0.49 ± 0.38 LogMAR to 0.47 ± 0.39 LogMAR (p=0.03, n=610) three years after the procedure, while best spectacle corrected visual acuity (BSCVA) improved from 0.15 ± 0.14 LogMAR to 0.14 ± 0.15 LogMAR (p=0.007, n=610). A significant reduction of Kmax from 56.28 ± 6.10 to 54.98 ± 6.19 (p<0.001,n=610) was observed three years after CXL. In five eyes (0.82%, 5/610) keratoconus progression continued after CXL. Three eyes were retreated successfully with documented refractive and topographic stability after five years. Eleven eyes had a reduction of BSCVA of 1 or 2 lines, mostly related to anterior stromal scarring. No cases of infectious keratitis occurred, whereas peripheral sterile infiltrates were observed in 1.13 % (n=886) of cases. In the thirty five eyes that completed 10 years of follow-up, mean visual acuity and topographic parameters remained stable.Conclusions:CXL is a safe and effective treatment for avoiding keratoconus progression. Long-term data is encouraging, supporting a high safety profile for this procedure.
Pharmacokinetic Study of the Main Components of Tanreqing Capsules and Tanreqing Injections in beagles by liquid chromatography–tandem mass spectrometry
Authors: Cui Lili , Wang Liang , Xu Deduo , Wang Zhipeng , Chen Yong , Song Xinhua , Xu Fengjing , Gao Shouhong , Tao Xia , Chen Wansheng
Published: August 2022

Background
Tanreqing capsules (TRQCs) and Tanreqing injections (TRQIs) are traditional Chinese medicine compound preparations that are widely used in the treatment of respiratory diseases. Although the ingredients of the two formulations are the same, differences in the way they are metabolized may affect their relative efficacy. In this study, a simple, rapid, and sensitive liquid chromatography–tandem mass spectrometry (LC-MS/MS) method was developed for simultaneous quantification of the main components of Tanreqing, which include chlorogenic acid, ursodeoxycholic acid, chenodeoxycholic acid, and baicalin, in beagle dog plasma to compare the pharmacokinetic parameters resulting from TRQI and TRQC administration.
Method
Plasma samples were pretreated with protein precipitation. Chromatographic separation was performed on a Waters Acquity UPLC HSS T3 (2.1 × 100 mm, 1.8 µm) column using a gradient elution with (A) 0.1% (v/v) formic acid aqueous solution and (B) acetonitrile. Six healthy beagles were divided into two groups, and a crossover, comparative pharmacokinetic study of TRQC (0.09g/kg) and TRQI (0.5 mL/kg) after a single-dose administration or daily doses over 7 days was carried out. One group was administrated a single dose of TRQC and followed continuously for 7 days, whereas the other group was treated with TRQI in the same way.
Results
The major pharmacokinetic parameters of the four compounds were not significantly different between the two formulations (P > 0.05).
Conclusions
The measured levels of the four major components of TRQCs and TRQIs were consistent in these dogs, providing a reference for the clinical application of TRQCs instead of TRQIs.
A Prefetch Control Strategy Based on Improved Hill Climbing Method in Asymmetric Multi-Core Architecture
Authors: Fang Juan , Xu Yixiang , Kong Han , Cai Min
Published: August 2022

Cache prefetching is a traditional way to reduce memory access latency. In multi-core systems, aggressive prefetching may harm the system. In the past, prefetching throttling strategies usually set thresholds through certain factors. When the threshold is exceeded, prefetch throttling strategies will control the aggressive prefetcher. However, these strategies usually work well in homogeneous multi-core systems and do not work well in heterogeneous multi-core systems. This paper considers the performance difference between cores under the asymmetric multi-core architecture. Through the improved hill-climbing method, the aggressiveness of prefetching for different cores is controlled, and the IPC of the core is improved. Through experiments, it is found that compared with the previous strategy, the average performance of big core is improved by more than 3%, and the average performance of little cores is improved by more than 24%.