bluuebunny/crossref_metadata_2025 huggingface dataset:
Cardiovascular Risk Assessment Among Workers in the West Attica Landfill
Authors: Vladeni Z. , Douna E. , Koupidis S. , Savourdos P. , Makrynos G. , Vitale E. , Dounias G.
Published: January 2025

Introduction: Landfill workers are frequently exposed to a multitude of deleterious factors that can adversely affect their health. These include environmental contaminants such as dioxins, furans, biogas, and heavy metals, as well as occupational hazards like noise, vibration, and extreme temperatures. Aims and Scope: This pilot study, conducted at the Integrated Solid Waste Management Facility of Fili (OEDA Filis), aimed to measure environmental risk parameters and assess their effects on the cardiovascular health of workers. Method: Data collection involved questionnaires to record personal history, work stress and job positions, clinical examinations, and blood lipid tests. Cardiovascular risk (Heart Score) was evaluated based on standards set by the Hellenic Heart Association, which incorporated the Heart Score using Greek data. Results: The majority of employees at OEDA Filis were married men from lower socioeconomic backgrounds, with 77% reporting no chronic health issues and self-assessing their health status as good. Most subjects had body mass indices categorized as either normal or overweight. Environmental assessments identified elevated concentrations of PM10 and phenanthrene in the workplace, though levels of benzo(a)pyrene and naphthalene were within safety thresholds. About 21% of the workforce was identified as being at considerable risk for cardiovascular disease. No statistically significant relation was found between the Heart Score and job positions (p = 0.3), indicating that occupational role alone does not predict cardiovascular risk. However, elevated Heart Scores were more frequently observed among positions with greater exposure to environmental and occupational hazards. Conversely, office workers, who had reduced exposure to exhaust, noise, and air pollutants, exhibited lower Heart Scores. Univariate analysis showed a significant association between occupational stress and Heart Score (p = 0.037); workers under high stress had significantly lower levels of high-density lipoprotein (HDL) (p = 0.006). Additionally, a significant association existed between the use of personal protective equipment (PPE) and lower Heart Score risk index values (p = 0.012), highlighting the protective impact of PPE in mitigating cardiovascular risk among exposed workers. Conclusion: This study enhances understanding of the associations between cardiovascular risk and exposure to environmental and occupational hazards at landfill sites. It underscores the critical need to establish a specialized observatory for continuous monitoring of occupational health and safety at these locations. Such an observatory should include regular health assessments for workers and systematic monitoring of environmental pollutants. Furthermore, the study advocates for initiatives aimed at improving the cardiovascular health of landfill workers, underscoring their necessity in this high-risk occupational environment.
Metsovo Lung: History of Population Environmental Exposure to Asbestos
Authors: Sxiza C. , Zagorianakou N. , Vlami C. , Farantos G. , Rapisarda V. , Dounias G.
Published: January 2025

Objectives: Our aim is to review all the literature concerning Metsovo Lung as an emblematic story that demonstrates the strong relationship between non-occupational but environmental and ecological exposure to asbestos and lung diseases. Materials and Methods: We searched data from the 1970s when extensive pleural calcifications causing malignant mesothelioma appeared at a high incidence beyond expectation. The most reliable studies were selected for our research from 2017-2023. Results: There wasn’t occupational exposure in Epirus. This finding reasonably raised the question of whether it was indeed tuberculous pleurisy or something else. The biopsies carried out confirmed that these were tremolite asbestos fibers. These fibers were derived from ‘luto’, a water-shielding material containing asbestos. The entire population of Metsovo was exposed to asbestos, without knowing it. This is a global phenomenon, according to which, it is made from a traditional shielding material. The abandonment of ‘luto’ and its non-use brought about a gradual reduction of the phenomenon, which also marks the reduction of mesothelioma. Conclusion: Lessons learned from the history of Metsovo lung showed the importance of the combination of theory and practice in the context of nonoccupational exposure to asbestos. From a public health point of view, it's crucial to know whether exposure to low levels of asbestos is able to induce pleural mesothelioma.
Study of Indoor Air Quality in School Buildings in the Argolida Sector of the Peloponnese Region in Greece and Potential Health Risks
Authors: Bikaki Maria Anna , Dounias Georgios , Cavoura Olga , Farantos Georgios , Damikouka Ioanna , Evrenoglou Lefkothea
Published: January 2025

Aims and Scope: Indoor air quality (IAQ) in schools is crucial, as students spend significant time in school environments in addition to their homes. Epidemiological researches have shown that indoor pollutants are linked to various health and respiratory issues. This paper focuses on investigating the indoor air quality (IAQ) in school buildings in the Argolida sector of the Peloponnese Region in Greece. Methods: The study was conducted in fourteen (14) classrooms across seven (7) school buildings in the Argolida Sector of the Peloponnese Region from March 2022 to May 2023. Physical parameters such as temperature (T) and relative humidity (RH), as well as air pollutants including Carbon monoxide (CO), Carbon dioxide (CO2), Nitrogen dioxide (NO2), Volatile Organic Compounds (VOCs), and Particulate Matter (PM10, PM2.5) were monitored using the series 500 Portable Air Quality Monitor AeroQual. Measurements were taken for one teaching hour per day in each classroom. Due to governmental measures to protect public health from the spread of COVID-19, some windows and doors in the classrooms were opened during sampling. Findings: The mean temperature and relative humidity inside the classrooms were 22.12 oC and 50.87%, respectively. The overall mean concentrations of air pollutants recorded inside the schools were 691.35 ppm CO2, 0.001 ppm NO2, 9.97 ppm VOCs, 15.7μg/m3 PM10, and 11.4μg/m3 PM2.5. No indoor CO concentration (0 ppm) was detected in any of the classrooms. This study indicated the following: a) the indoor CO2 concentration levels in the schools (100%) were below 1000 ppm, b) in five out of the fourteen classrooms (35.7%) within the school buildings, CO2 concentration levels exceeded 700 ppm, and c) the indoor VOCs levels in the schools (100%) were above 0.8 ppm. Eight classrooms (57.1%) in Argolida’s school buildings had no comfort conditions due to high relative humidity (RH > 50%). Statistically significant differences were found for temperature (p= 0.001), CO2 (p < 0.001), NO2 (p=0.006), and VOCs (p=0.001) between indoor and ambient air. Conclusion: The air quality in school buildings in the Argolida sector was affected by the number of students in a classroom, the ventilation rate, and the school’s equipment. The proximity of schools to central roads and construction activities also affected the concentration of indoor air pollutants. Indoor air pollution (IAP) can pose potential health risks. Developing monitoring systems for measuring indoor pollutants in schools, as well as strategies for controlling and improving IAQ, is essential for public health.
Retrospective analysis of disease characteristics and treatment patterns among patients with esophageal cancer across 14 surgically represented centers
Authors: Lu Zhihao , Geng Mingfei , Han Yongtao , Cao Jianzhong , Wang Jun , Liu Tianshu , Yuan Xianglin , Meng Xue , Zhang Yanqiao , Zhao Rong , Wan Lixin , Li Enxiao , Wang Wenran , Li Zhijie , Shi Danfeng , Qian Jing , Shi Si , Dong Fengshi , Shen Lin
Published: January 2025

Objective: Esophageal cancer (EC) ranks eighth among cancers in cancer-related deaths globally, and ~44% of new cases occur in China. We sought to describe the clinical characteristics and treatment landscape of EC in China before the approval of immunotherapy in 2020. Methods: CHANNEL was a large, retrospective study using patient-level data from 14 hospitals/cancer centers across China, including adults initiating therapy for newly diagnosed EC (January to December 2018). Demographics, clinicopathologic characteristics, and treatment patterns over 6 months were descriptively summarized. Results: Of 3,493 patients, 75.7% were men, the mean age was 64.1 years, and 75.0% had no family history of cancer. Most (92.8%) had squamous cell carcinoma, with a primary lesion in the middle esophagus (56.4%). Among patients with resectable EC, 92.9% received initial surgery, and 7.1% received neoadjuvant therapy, primarily chemotherapy (85.5% platinum-taxane). Among patients with unresectable early or locally advanced EC, 50.8% and 49.2% received palliative and radical therapy, respectively, as the initial treatment, primarily chemotherapy (66.5% platinum-taxane) and chemoradiotherapy (50.8% platinum-taxane), respectively. Adjuvant therapy was administered to 22.9% of patients undergoing initial surgery, and 2.4% receiving neoadjuvant therapy and surgery. Among patients with advanced EC, 84.6% received systemic therapy as an initial treatment, primarily chemotherapy (61.5% platinum-taxane). Conclusions: Before the approval of immunotherapy in China, most patients with resectable early or locally advanced EC underwent radical surgery without preoperative treatment, whereas most patients with advanced EC received platinum-taxane chemotherapy. These findings highlight the need for novel EC treatments before immunotherapy was introduced, and provide a baseline for evaluating the benefits of immunotherapy, now that this treatment is widely used in this setting.
Improving systemic delivery of oncolytic virus by cellular carriers
Authors: Peng Ziyi , Kalim Muhammad , Lu Yong
Published: January 2025

Oncolytic virotherapy (OVT) is a promising option for cancer treatment. OVT involves selective oncolytic virus (OV) replication within cancer cells, which triggers anti-tumor responses and immunostimulation. Despite promising potential, OVT faces critical challenges, including insufficient tumor-specific targeting, which results in limited tumor penetration and variability in therapeutic efficacy. These challenges are particularly pronounced in solid tumors with complex microenvironments and heterogeneous vascularization. A comprehensive research program is currently underway to develop and refine innovative delivery methods to address these issues to enhance OVT precision and efficacy. A principal area of investigation is the utilization of cellular carriers to enhance the delivery and distribution of OVs within tumor microenvironments, thereby optimizing immune system activation and maximizing anti-tumor effects. This review offers a comprehensive overview of the current strategies that are being used to enhance the delivery of OVs via cellular carriers with the goal of improving the clinical impact of OVT in cancer therapy.
Heatmaps to Guide Siting of Solar and Wind Farms
Authors: Cheng Cheng , Silalahi David Firnando , Roberts Lucy , Nadolny Anna , Weber Timothy , Blakers Andrew , Catchpole Kylie
Published: January 2025

Decarbonization of the electricity system coupled with electrification of transport, heat and industry represents a practical and cost-effective approach to deep decarbonization. A key question is: where to build new solar and wind farms? This study presents a cost-based approach to evaluate land parcels for solar and wind farm suitability using colour-coded heatmaps that visually depict favourable locations. An indicative cost of electricity is calculated for each pixel by focusing on key factors including resource availability, proximity to transmission infrastructure or load centres, and exclusion of sensitive areas. The proposed approach mitigates the subjectivity associated with traditional multi-criteria decision-making methods, in which both the selection of siting factors and the assignment of their associated weightings rely highly on the subjective judgments of experts. The methodology is applied to Australia, South Korea, and Indonesia, and the results are made publicly available to provide both qualitative and quantitative information that allows comparisons between regions and within a region. The study aims to empower policymakers, developers, communities and individual landholders to make informed decisions, and ultimately, facilitate strategic renewable energy deployment and contribute to global decarbonization. 
Characterization of Euglena gracilis Mutants Generated by Long-Term Serial Treatment with a Low Concentration of Ethyl Methanesulfonate
Authors: Kang Ji-Yeon , Ban Younglan , Shin Eui-Cheol , Kwon Jong-Hee
Published: January 2025

Euglena gracilis is a microalga that has great promise for the production of biofuels, functional foods, and bioactive compounds, and mutagenesis and effective screening methods are required to develop Euglena strains that have industrial use. Ethyl methanesulfonate (EMS) is widely used mutagen, but is highly lethal to Euglena at typical concentrations. In the present study, low-concentration, long-time EMS exposure combined with serial treatment was introduced for generating Euglena mutants. We then used screening protocols to select cells with altered motility or pigmentation, and isolated two distinct strains of Euglena: Mutant 333 and Mutant 335. Mutant 335, which had a deficiency of chlorophyll, had a high paramylon content (31.62%) and a mild and pleasant odor profile due to decreased concentrations of certain volatile compounds, with confirmation by GC-MS analysis. In contrast, Mutant 333, it was found that an increase in Euglena's motility leads to a decrease in differentiation rate and paramylon content (13.5%), making it unsuitable for industrial applications.
Design of an Integrated Multi-Channel Radio Frequency Source for the Transportable 40Ca+ Ion Optical Clock
Authors: Wang Bin , Yang Yuanhang , Zhang Huaqing , Hu Ruming , Mao Haicen , Huang Yao , Gao Kelin , Guan Hua
Published: January 2025

As one of the most accurate instruments in history, the optical clock will be used as the measuring equipment for the next generation of seconds. The demand for miniaturization of optical clock is progressively urgent. In this paper, a multi-channel radio frequency module with a 20% volume of the commercial module is designed and implemented for the transportable 40Ca+ ion optical clock. Based on the double crystal oscillator interlocking technique，1 GHz low-phase noise reference source is developed for direct digital synthesis. By simulation and optimization of the signal link design, a frequency range of the low-phase noise RF signal can reach 0-400 MHz with a 4 μHz resolution. Through two-stage power amplified with different kinds of filters, it can get an output power up to +33 dBm (2 W) at 100 MHz with a 25 dBc/Hz phase noise lower than the commercial module at 1 Hz, and its third harmonic suppression ratio has been reduced by more than 20 dBm at the frequency point of 300 MHz. This multi-channel RF module is used for the power stability and timing control test of 729 nm clock laser, to meet the requirements of the transportable 40Ca+ optical clock. Without this, this module can also be applied to other quantum systems such as quantum absolute gravimeter, quantum gyro and quantum computer.
EFEKTIVITAS PEMBELAJARAN KEBINEKAAN MODUL NUSANTARA DENGAN MODEL PENGAJARAN QUALITY, APPROPRIATENESS, INCENTIVE, DAN TIME (QAIT)
Authors: Wawan Syahputra Wijaya  , Ivan Hanafi  , Z.E. Ferdi Fauzan Putra
Published: January 2025

Kegiatan pembelajaran Kebinekaan Modul Nusantara adalah salah satu bentuk implementasi dari kurikulum Merdeka Belajar – Kampus Merdeka pada program Pertukaran Mahasiswa Merdeka. Kegiatan tersebut memberi kesempatan untuk mahasiswa dalam mengeksplorasi bentuk keragaman budaya setempat dan menerapkan makna toleransi di dalamnya. Tujuan dari penelitian ini adalah untuk menganalisis keberhasilan dari kegiatan pembelajaran tersebut pada mahasiswa inbound Universitas Negeri Jakarta Angkatan II. Metodologi penelitian yang digunakan adalah pendekatan kualitatif dengan metode studi kasus. Komponen dan aspek yang digunakan adalah model pengajaran QAIT dan subjek penelitian berfokus pada mahasiswa. Hasil penelitian ini menemukan bahwasanya kegiatan pembelajaran Kebinekaan Modul Nusantara telah mencapai keberhasilan dalam penerapan kurikulum Merdeka Belajar – Kampus Merdeka. Hal tersebut didukung pada kualitas materi dan kegiatan pembelajaran yang telah memenuhi tujuan pembelajaran, kemampuan mahasiswa yang baik dan siap untuk mengikuti kegiatan pembelajaran, pemberian dorongan berupa motivasi untuk mahasiswa, serta waktu yang dialokasikan dan dimaksimalkan telah diberikan dan dimanfaatkan dengan baik.
PENGEMBANGAN MEDIA BELAJAR E-BOOK INTERAKTIF BERBASIS FLIP PADA MATA PELAJARAN ADMINISTRASI INFRASTUKTUR JARINGAN KELAS XII SMK KSATRYA MENGGUNAKAN METODE LUTHER-SUTOPO
Authors: Hauzan Nabil Hawali  , Muchammad Ficky Duskarnaen  , Bambang Prasetya Adhi
Published: January 2025

Buku konvensional tidak menyediakan kegiatan interaktif yang merangsang keterlibatan siswa secara aktif. Siswa hanya dapat membaca teks yang disajikan dalam buku tanpa adanya fitur interaktif seperti audio, video, atau konten multimedia lainnya. Oleh karena itu karena itu pengembangan media ajar interaktif mata pelajaran Administrasi Infrastruktur Jaringan SMK Ksatrya sebagai sebuah penelitian dengan tujuan membantu proses pembelajaran agar dengan mudah dimengerti serta meningkatkan minat belajar siswa. E-book interaktif ini menyajikan materi pembelajaran interaktif, gambar interaktif, materi berbentuk video pembelajaran interaktif dan quiz interaktif. E-book interaktif ini dikembangkan dengan metode Multimedia Development Life Cycle (MDLC) terdiri dari enam tahap, yaitu concept, design, material collecting, assembly, testing dan distribution. Data yang digunakan dalam penelitian ini adalah hasil observasi dan wawancara kepada Kepala Program Teknik Komputer Jaringan SMK Ksatrya. Penelitian ini diuji dengan pengujian Skala Guttman untuk Ahli materi mendapatkan penilaian 100% interval “Sangat Layak”, Skala Likert untuk Ahli media mendapatkan penilaian 89,41% interval “Sangat Layak” dan System Usability Scale untuk responden mendapatkan penilaian 88,10% interval “Sangat Layak”. E-book ini diharapkan dapat digunakan dan dapat membantu proses pembelajaran dengan baik di Sekolah Menengah Kejuruan Katrya.
PERANCANGAN DAN IMPLEMENTASI ANTARMUKA PENGGUNA SISTEM INFORMASI BERBASIS WEBSITE SMK NEGERI 6 JAKARTA DENGAN METODE PROTOTYPE
Authors: Riyadhul Firdaus  , Muchammad Ficky Duskarnaen  , Bambang Prasetya Adhi
Published: January 2025

Informasi tentang sekolah biasanya dicari calon murid dan calon orang tua murid untuk mencari informasi mengenai sekolah untuk menentukan tujuan pendaftaran sekolah, Untuk menyebarkan informasi sekolah, salah satu caranya menggunakan website sistem informasi sekolah, berdasarkan wawancara dan kuesioner didapatkan bahwa SMKN 6 Jakarta memiliki website namun masih dirasa kurang aktif dan desain antarmuka yang kurang menarik, fungsi yang masih sedikit, serta kurang responsif. Penelitian ini bertujuan untuk mengembangkan prototype frontend sistem informasi berbasis website SMKN 6 Jakarta. Pengembangan sistem menggunakan SDLC Prototype dengan 5 tahapan, Communication, Quick Plan, Modeling Quick Design, Prototype Construction, Deployment, Delivery, & Feedback. Pada proses pengembangannya dilakukan tiga kali iterasi yang setiap iterasinya dilakukan pengujian fungsional menggunakan blackbox dan pengujian penerimaan menggunakan UAT. Dan pada iterasi ketiga prototype frontend dapat diterima oleh pengguna berdasarkan hasil dari UAT. Setelah prototype frontend diterima, dilakukan integrasi untuk menghasilkan sistem informasi berbasis website SMKN 6 Jakarta yang diuji menggunakan blackbox dengan hasil semua fungsi menghasilkan status “berhasil”, kemudian diuji usability menggunakan SUS menghasilkan total skor SUS sebesar 84,45, kemudian skor SUS diterjemahkan kedalam beberapa aspek. Aspek Acceptance didapatkan sistem dapat diterima, kemudian aspek Grade didapat sebesar A+ yaitu kualitas sangat baik, dan aspek Adjective didapat nilai Best Imaginable.
Анализ динамики эпидемического процесса COVID-19 в мире за неделю с 11.01.2025 г. по 17.01.2025 г.
Authors: Зимирова Анастасия , Поспелов Михаил , Иванова Александра , Карнаухов Игорь , Щербакова Светлана , Кутырев Владимир , Дмитриева Людмила , Чумачкова Елена
Published: January 2025

В обзоре представлен анализ эпидемиологической ситуации в странах мира по COVID-19 за неделю с 11.01.2025 г. по 17.01.2025 г.
ANALISIS PENGARUH PROFIL SUDUH TERHADAP DAYA TURBIN VORTEX
Authors: Marfizal Marfizal , Sufiyanto Sufiyanto , Wardianto Dedi
Published: January 2025

Turbin vortex adalah turbin yang beroperasi dengan memanfaatkan aliran vortex sebagai penggerak sudu-sudu turbin yang kemudian poros turbin dihubungkan ke generator untuk mengkonversi energi mekanis poros kedalam bentuk energi listrik. Pada penelitian ini akan dilakukan pengujian terhadap turbin vortex dengan head 1 m, debit aliran 0,12 m3/s. dalam proses pengujian akan di gunakan 3 jenis sudu, yaitu sudu lurus, sudu lengkung dan sudu lengkung bersirip. Setelah dilakukan pengujian dapat disimpulkan bahwa  daya tertinggi terdapat pada sudu lengkung  sebesar 959,08 watt dan  berikutnya sudu lengkung bersirip   714.38 watt, sedang kan daya terendah terdapat pada jenis sudu lurus 582.48 Watt. Untuk putaran yang dihasilkan dapat terlihat pada grafik dibawah,   Putaran  tertinggi terdapat pada sudu lengkung   bersirip sebesar 540,00 rpm dan  berikutnya sudu lengkung    517.67 rpm, sedang kan putran terendah terdapat pada jenis sudu lurus 510.67 rpm. Untuk effisiensi masing masin sudu terhat bahwa sudu lengkung masih tertinggi dan diikuti sudu jenis lengkung bersirip, terendah sudu lurus dengan effisiensi masin masin 98 %, 73 % dan 59%.
PENGARUH PENAMBAHAN ABU ARANG TEMPURUNG KELAPA TERHADAP KUAT TEKAN PAVING BLOCK
Authors: A Arman , Mulyati Mulyati , Wardi Syafri , Roza Angelalia , Sonia Putra Didi
Published: January 2025

Paving Block adalah bahan bangunan yang dibuat dari campuran semen, pasir dan air. Paving Block banyak digunakan dalam bidang konstruksi, seperti tortoar, jalan raya, lahan parkir, taman dan lainnya. Kemudahan dalam pemasangan, perawatan yang murah serta memenuhi aspek keindahan mengakibatkan paving block lebih banyak disukai. Seiring dengan banyaknya pembangunan seperti rumah, taman, jalan di tengah-tengah masyarakat saat ini, sehingga mengakibatkan kebutuhan paving block semakin meningkat. Karena proses pengerasannya membutuhkan waktu yang cukup lama, maka dari itu untuk mempercepat pengerasan, penelitian ini menanbahkan bahan Abu Tempurung Kelapa. Dalam penelitian ini menggunakan perbandingan 1 Pc: 3 Ps dan ditambahan Abu Tempurung kelapa dengan Variasi 0 %, 2,5 %, 5 %, dan 7,5 % dari berat semen. Nilai kuat tekan paving block rencana rata-rata Minimal 12,5 MPa dan Maksimal 15 MPa untuk mutu C yang dipergunakan untuk Pejalan kaki dan penggunaan lain, dengan benda uji persegi panjang dengan ukuran 20 cm x 10 cm x 6 cm sebanyak 24 buah dengan umur pengujian 28 hari untuk pengujian kuat tekan dan penyerapan air. Berdasarkan hasil pengujian didapatkan nilai kuat tekan paving block normal sebesar 13 Mpa, penambahan Abu Tempurung Kelapa 2,5 % didapatkan sebesar 13,5 MPa, Abu Tempurung 5 % didapatkan sebesar 14,5 Mpa, Penambahan Abu tempurung 7,5 % didapatkan sebesar 12,83 Mpa. Berdasarkan hasil pengujian didapatkan nilai penyerapan air Paving Block normal sebesar 7,8 %, Abu Tempurung 2,5 % sebesar 7,22 %, Penambahan Abu Tempurung 5 % sebesar 6,3 %, Abu Tempurung 7,5 % sebesar 4,89%. Dengan demikian dapat dinyatakan bahwa pengaruh Abu Tempurung Kelapa dapat meningkat kuat tekan dam menurunkan penyerapan air. Kuat tekan tertinggi dan penyerapan air terendah di peroleh pada penambahan 5% untuk kuat tekan dan penyerapan Air terendah diperoleh penambahan 4,89 %.
Plan de negocios para la venta de productos para mascotas por tienda on-line en el mercado de Lima moderna
Authors:   , Mateo Casani Stephani Maruli
Published: January 2025

La economía peruana muestra día a día mayor dinamismo luego de capitalizar un crecimiento de 1.4% durante el primer trimestre del 2024, según el informe del Instituto peruano de economía. Para el siguiente año, el Instituto Peruano de la Economía indica el pronóstico de crecimiento en un porcentaje de 2.8. En el 2025 se pronostica riesgos sobre el gasto privado debido a la incertidumbre por unas nuevas elecciones presidenciales.
Aproximadamente el 58% de los hogares en el Perú tiene al menos una mascota, según los resultados de un estudio de IPSOS APOYO. Los jóvenes son los mayores promotores de este pensamiento de amor a los animales.
Por otro lado, IPSOS realizó un estudio al consumidor 2024, donde indica los nuevos comportamientos y tendencias del consumidor peruano sobre las compras por internet, donde nos refleja que en el Perú urbano de 18 a 70 años de los niveles socio económicos A, B, C y D, las compras que realizan de productos de mascotas es del 22%.
A raíz del aumento por el interés del cuidado de las mascotas, está haciendo que más personas se interesen por invertir en este rubro. Además, que es una buena alternativa en la actualidad, ya que la venta de PetShop online creció entre 50% y 70%, lo indica el CEO de Provet. Considerar también que no es necesario tener una tienda física, además permite con el tiempo diversificar el negocio, factores importantes que muchos emprendedores hoy en día deciden invertir en un negocio de este rubro...
Low-dose Rivaroxaban versus Warfarin in Patients Early after Bioprosthetic Valves Replacement
Authors: Guo Rui , Luo Ying , Wang Shuwei , Liu Zhifang , Zhang Dan , Hou Leping , Xing Mengyu , Xu Shuang , Luo Dan
Published: January 2025

This study aims to evaluate the effects of low-dose rivaroxaban in patients during the initial three months following bioprosthetic valve replacement. In this retrospective study, we compared low-dose rivaroxaban (15 mg once daily) with dose-adjusted warfarin (target international normalized ratio of 2.0 to 3.0) in patients who received a bioprosthetic valve replacement within the first three months. Primary efficacy outcome was the incidence of thromboembolic complications, while primary safety outcome was the incidence of bleeding within three months post-surgery. A total of 380 patients were enrolled at a large teaching hospital. The primary efficacy outcome occurred in 1 patient in both the warfarin and the rivaroxaban groups (p < 0.001 for noninferiority). There were no deaths in either group. 19 patients experienced the primary safety outcome; specifically, bleeding events occurred in 7 patients in the rivaroxaban group and in 12 patients in the warfarin group (7/178 vs. 12/189, p < 0.001 for noninferiority). After propensity score matching, the prevalence of clinical thromboembolic events was comparable between the two groups (1/130 vs. 0/130, p < 0.001 for noninferiority). The incidence of bleeding events in the rivaroxaban group was found to be noninferior to that in the warfarin group (6/130 vs. 6/130, p < 0.001 for noninferiority). In the early three months following bioprosthetic valve replacement, low-dose rivaroxaban demonstrated noninferiority to warfarin with respect to the incidence of primary outcomes (death, major cardiovascular events, or major bleeding).
AI and Blockchain For Next-Generation E- Governance: A Comprehensive Bibliometric Review In Smart City Innovation
Authors: Lubis Sandi , Nurmandi Achmad , Ahmad Jamaluddin , Purnomo Eko Priyo , Purwaningsih Titin , Jovita-Olvez Hazel D.
Published: January 2025

The merging of AI and blockchain technologies offers essential potential for e-governance, especially in improving predictive policy execution within smart cities. This study thoroughly reviews and assesses existing literature to clarify trends, key publications, and research gaps. Using detailed bibliometric analysis, we explored peer-reviewed articles from well-respected publishers indexed by Scopus, concentrating on works published from 2019 to 2024. Our results reveal an increasing volume of research examining the separate applications of AI and blockchain in e-governance. However, there is a noticeable lack of empirical studies focusing on their combined implementation. Major themes identified include the possibility of improved transparency and efficiency in public services, issues related to interoperability, and ethical considerations about data privacy and algorithmic accountability. This study is constrained by its dependence on bibliometric methods, which may not entirely reflect the practical complexities of technology integration across various governance contexts. Future research should emphasize longitudinal case studies and pilot initiatives to evaluate real-world uses of AI and blockchain in e-governance, addressing regulatory and ethical challenges to promote responsible adoption. This work adds to the global discussion on digital governance, providing a foundational framework for advancing AI and blockchain-enabled smart city projects.
KIFC1 overexpression promotes pancreatic carcinoma progression via stabilizing BUB1
Authors: Fu Xiaowei , Cui Ao , Yu Ying-Xue , Wang Ji-Yang , Zou Ye-Qing , Zhu Ya-Qiong , Ran Long-Jian , Zhang Yu , Liu Rui-Xiang , Dong Mingyi , Wang Hui , Fang Lu
Published: January 2025

Pancreatic cancer (PC) is a highly lethal tumor of the gastrointestinal tract. New molecular targets are urgently needed for its treatment. Kinesin family member C1 (KIFC1) is implicated in the development and progression of several types of cancer. Previously, our studies indicated that KIFC1 is overexpressed in hepatocellular carcinoma and activates the malignant behavior of hepatocellular carcinoma through the PI3K/AKT pathway. However, the molecular and functional mechanisms of KIFC1 in PC have not been investigated. In this study, KIFC1 and BUB1 were significantly upregulated in PC patient samples, and high KIFC1 expression was closely associated with the malignant phenotype and poorer overall survival (OS) in PC patients. Functional experiments showed that KIFC1 knockdown inhibited PC cell growth in vivo and in vitro, blocked cell cycle progression, and hindered cell migration invasion. In addition, reply experiments showed that KIFC1 induced PC cell malignant behaviors dependent on BUB1. Mechanistically, KIFC1 regulates BUB1 expression by competitively binding to BUB1 and reducing its ubiquitination and degradation. We have shown for the first time the molecular regulatory mechanism between KIFC1 and BUB1 in PC Therefore, KIFC1 shows promise as an attractive therapeutic target for PC in the future.
Robust Conductivity of Goldene Against Structural Defects and Mechanical Deformations: A First-Principles Study
Authors: Berdiyorov G. R. , Aissa B.
Published: January 2025

One of the principal challenges in flexible and stretchable electronics is identifying materials that maintain high electrical conductivity under mechanical deformations. Low-dimensional materials like graphene offer substantial benefits due to their mechanical robustness and inherent high conductivity. However, their electrical performance is significantly compromised by mechanical stresses and structural defects such as vacancies and dislocations. Here, we study the effects of structural defects and mechanical deformations on the electronic transport properties of goldene, a single layer of hexagonally arranged gold atoms, to explore its potential for flexible electronics. Our quantum transport calculations reveal that goldene maintains its conductivity effectively, exhibiting only a 1.7% reduction in conductance under a tensile strain of 5%. Additionally, the introduction of single and divacancy defects results in conductance reductions of only 2% and 3%, respectively. Most importantly, goldene’s conductivity remains robust under both bending and twisting, distinguishing it from graphene and positioning it as an outstanding candidate for flexible nanoelectronics.
Post-operative endophthalmitis following routine photorefractive keratectomy (PRK) with succinylcholine anayphlyaxis and extrusion of ocular contents during therapeutic penetrating keratoplasty (PKP)
Authors: Power Barry , Crawford Alex , Wang Michael , Subbiah Shanu
Published: January 2025

Background
Endophthalmitis is an exceptionally rare but devastating complication following laser corneal refractive surgery.
Case Presentation
We present a case of Pseudomonas aeruginosaendophthalmitis following routine myopic photorefractive keratectomy with mitomycin C application. The patient was referred to a tertiary ophthalmic service with severe post-operative infectious keratitis following initial management at another centre and was treated with intensive fortified antibiotics. The eye subsequently developed endophthalmitis with corneal perforation necessitating urgent pars plan vitrectomy facilitated by a temporary keratoprosthesis and subsequent therapeutic penetrating keratoplasty. During anaesthetic induction, the patient developed life-threatening anaphylaxis, most likely secondary to succinylcholine. Aggressive posterior positive pressure was encountered intraoperatively resulting in spontaneous extrusion of the iris and crystalline lens. We postulate that the posterior positive pressure was caused by several factors, including massive inflammation, and fluid shifts secondary to anaphylaxis and its associated management. The positive pressure was successfully managed and a keratoprosthesis was secured allowing completion of vitrectomy and therapeutic penetrating keratoplasty. At 6-month follow-up, the vision remains at light perception
Conclusion
Endophthalmitis is an exceptionally rare but devastating complication following laser corneal refractive surgery, and the use of mitomycin C might have contributed to the rapid progression observed in the current case. Our report also highlights that acute anaphylaxis and its management can lead to posterior positive pressure, and measures should be taken to reduce the potential impacts before intraocular surgery and full-thickness incisions are made.
Emperor Glycerius and Praetorian Prefect Himelco on ‘Simony’: A New Critical Edition of a Legal Dossier
Authors: Vanspauwen Aäron
Published: January 2025

This article offers a study of a fifth-century Roman legal dossier concerning the ordination of clergy. The dossier consists of a letter by Emperor Glycerius (473-474) and an edict by Praetorian Prefect Himelco. The dossier is preserved in two Carolingian manuscripts, and has not yet been critically edited. Its current edition is that of the Ballerini brothers, published in 1757, on the basis of only one manuscript. The article is divided in three sections: (I) an introduction to the dossier and the edition, (II) the new critical edition with English translation, and (III) notes in which I explain where the text of the edition may not be immediately evident from the manuscript readings. The introduction will discuss the textual transmission, the style of both texts, and the editorial principles of the new edition.
Ein Marxist der ersten Stunde – Der DDR-Althistoriker Gerhard Schrot (1920-1966)
Authors: Willing Matthias
Published: January 2025

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Cirurgia de Frenectomia Lingual em Paciente Odontopediátrico: Relato de Caso
Authors: Pereira Emanoel Silva , Ferreira Flavya Dayane da Silva , Silva Sobrinho Adriano Referino da , Magalhães Vinícius Souto , Santos Thaysa Gomes Ferreira Tenório dos
Published: January 2025

O presente estudo tem como objetivo descrever um caso clínico de frenectomia lingual em um paciente pediátrico utilizando a técnica convencional. O paciente de 5 anos de idade, gênero masculino, feoderma, procurou a Clínica de Odontopediatria da Faculdade de Integração do Sertão acompanhado do seu responsável queixando-se de língua presa e dificuldade na fala. Ao examinar a língua, foi observado que ela apresentava um freio curto e inserido próximo à sua ponta, diminuindo sua motilidade e dificultando a fonética e dicção de palavras derivadas do “r” pelo paciente. O diagnóstico de anquiloglossia foi fechado, sendo indicado o tratamento cirúrgico. Após o exame clínico, realizou-se antissepsia intraoral com através do bochecho com solução de clorexidina a 0,2% e extraoral com clorexidina a 2%. Posteriormente, sob efeito da anestesia bilateral com lidocaína a 2% associado à epinefrina, efetuou-se a manobra de diérese com a tesoura goldman fox. Em seguida, divulsionou-se o tecido com a tesoura de ponta romba e sutura com fio de sutura seda 4.0. No relato de caso apresentado, a cirurgia de frenectomia realizada pela técnica convencional apresentou resultados satisfatórios, demonstrando ser uma etapa importante no tratamento da anquiloglossia quando bem indicada.
Dynamics analysis and experiment of banana-shaped vibrating-dewatering screen
Authors: Li Hongxi , Zhou Enhui , Jiang Haishen , Shen Ling , Yin Zixin , Jin Zujin
Published: January 2025

Banana-shaped Vibrating-Dewatering Screen (BVDS) is effective for dehydrate and demud sand aggregate, fine coal slime, ore and other materials. In this paper, the mechanical structure of the BVDS was revealed by means of theoretical modeling, simulation research and experimental test, and its dynamic and vibration characteristics were studied. The mathematical model was established, and the dynamic curve and spatial trajectory of the BVDS were obtained by MATLAB/Simulink software. Lissajous displacement diagram shows that the spatial motion trajectory of the shaker is an oblique line. The vibration test was carried out by using dynamic characteristic test system, and the dynamic characteristics of displacement, velocity and acceleration of the BVDS were revealed. Finally, through theoretical analysis, the changing trend of vibration characteristics of the BVDS with the increase of rotating velocity was obtained. The results show that the experimental data is basically consistent with the theoretical data, and the deviation is less than 6.58 %, which verifies the accuracy of the theoretical model. This paper provides a reference for the design and efficient operation of the BVDS.
ESTUDO DA PAISAGEM DOS BAIRROS RIBEIRINHOS DA ZONA SUL EM TERESINA, PIAUÍ
Authors: Santiago Denise Rodrigues , Matos Karenina Cardoso , Lopes Wilza Gomes Reis
Published: January 2025

O presente artigo tem como objetivo analisar a paisagem ribeirinha da zona Sul de Teresina, capital do estado do Piauí, identificando e caracterizando as diferentes paisagens através da delimitação de cenários. A análise fundamenta-se em pesquisas bibliográficas que abordam conceitos pertinentes ao tema, como espaços livres e paisagem, com o intuito de contribuir para o entendimento das dinâmicas ribeirinhas dos rios Poti e Parnaíba. A investigação realizou análises qualitativas com intuito de entender as questões sociais, urbanas e ambientais associadas a essas áreas. Além disso, o estudo incluiu visitas no local, levantamento fotográfico e análise de mapas cartográficos. Como resultado, foram identificadas diferentes paisagens na Zona Sul de Teresina, incluindo regiões mais densamente povoadas e outras menos, áreas suscetíveis a inundações, e uma diversidade no uso e ocupação do solo, que varia desde residências a grandes instalações institucionais. Também foi constatada a existência de apenas um parque ribeirinho, o Parque Ambiental da Prainha, que, embora tenha sido bastante frequentado na década de 1980, atualmente, enfrenta diversos impactos ambientais devido ao uso inadequado e ao abandono por parte das autoridades competentes. Conclui-se que é necessária uma ação mais eficaz por parte da sociedade e do poder público para promover a valorização e a recuperação da paisagem ribeirinha nesta região.
ESTRATÉGIAS INTEGRADAS DE SOLUÇÕES BASEADAS NA NATUREZA COMO POTENCIALIZADORAS DE CENTRALIDADES
Authors: Carvalho Gabriel Lincoln Lopes , LIRA Anneliese Heyden Cabral de , XAVIER ANDRADE DE OLIVEIRA JULIANA , Silveira José Augusto Ribeiro da
Published: January 2025

O artigo aborda os desafios contemporâneos enfrentados pelas cidades, destacando a expansão acelerada e desordenada como um fenômeno premente que impacta significativamente a salubridade do espaço urbano. Impulsionada pelo rápido crescimento demográfico e pela demanda crescente por infraestrutura e serviços urbanos, essa expansão gera uma série de problemas inter-relacionados. Uma preocupação central é a predominância do planejamento urbano voltado para o veículo automotor e a infraestrutura cinza, em detrimento de soluções sustentáveis. A infraestrutura cinza, caracterizada pela impermeabilização do solo, gera efeitos negativos, como o aumento das ilhas de calor urbanas e o risco de inundações. O adensamento construtivo exacerba problemas como poluição do ar e falta de espaços verdes. O artigo propõe uma análise crítica das estratégias integradas de Soluções Baseadas na Natureza (SbN) em um bairro, com o objetivo de contribuir para políticas públicas mais sustentáveis. O escolhido foi o bairro Varadouro, situado na área central de João Pessoa, que ilustra bem esses desafios por apresentar altos índices de vulnerabilidade e suscetibilidade a problemas ambientais, exibindo sérios problemas de degradação ambiental e social. A importância dessa pesquisa reside na necessidade de abordagens inovadoras e sustentáveis para enfrentar desafios urbanos contemporâneos, especialmente em áreas vulneráveis, destacando também a centralidade dessas áreas urbanas e sua influência em toda a estrutura municipal, corroborando a importância da análise e intervenção no bairro analisado para todo o município.
NBR 16.537
Authors: Silveira Carolina Stolf
Published: January 2025

A sinalização tátil no piso representa uma das formas de garantir o direito de ir e vir com independência das pessoas com deficiência visual, visando indicar caminhos preferenciais e seguros de circulação, assim como alertar para perigos potenciais. A norma brasileira NBR 16.537 (ABNT, 2016) de sinalização tátil no piso passou por revisão através de reuniões oficiais abertas de 2021 a 2022 conduzidas pela Associação Brasileira de Normas Técnicas (ABNT) com interessados em participar do processo de discussão dos itens que apresentavam problemas de usabilidade, aplicação prática e/ou exigiam melhor definição. Este artigo busca exemplificar as principais recomendações encaminhadas pela pesquisadora durante o processo de revisão da normativa, a partir do protagonismo dos próprios usuários: pessoas com cegueira, através dos resultados de pesquisa que aplicou os instrumentos Passeio Acompanhado e discussões em Grupo Focal, para que as sugestões à normativa pudessem ser estabelecidas durante as reuniões oficiais. A maioria das recomendações textuais e por desenhos técnicos foram acatadas na nova versão da norma publicada em 2024 pela ABNT, após ponderações e concordância majoritária dos participantes.
STEVEN HOLL E A ARQUITETURA FRACTAL
Authors: Brito Leonardo de Oliveira , Almeida Maristela de Moraes , Sakurai Tatiana
Published: January 2025

Tradicionalmente o projeto de arquitetura se fundamenta no conhecimento da “geometria euclidiana”, contudo, o advento da “geometria fractal” gerou discussões sobre sua projeção no desenvolvimento de projetos denominados internacionalmente como “arquitetura fractal”. Dessa maneira, o objetivo deste artigo é investigar a arquitetura fractal, considerando intenções projetuais de Steven Holl ao aplicar a geometria fractal no desenho de composição da forma arquitetônica do centro de convivência Sarphatistraat, obra desenvolvida no seu ateliê. Para isso, utiliza-se como referência as propriedades da geometria fractal, enfatizando-se a estruturação de uma estratégia de análise da forma arquitetônica no trabalho do arquiteto. A pesquisa envolveu o suporte de registro bibliográfico, com abrangência exploratória e descritiva, caracterizada por uma aproximação qualitativa do desenho a partir do material iconográfico da obra selecionada: texto, planta, corte, elevação, axonometria, perspectiva, diagrama ou modelo. Como resultado, registra-se que a geometria fractal atua como geradora de uma estrutura para formação de ponto, linha, plano, volume e abertura; por conseguinte, ocorre uma transformação que distorce a geometria fractal inspiradora indicada inicialmente pelo arquiteto. Contudo, permanece uma disposição ordenada entre as partes e o todo no desenho de composição da forma arquitetônica com base em atributos que envolvem o espaço arquitetônico. A obra analisada torna-se uma referência para elaborar propostas projetuais em arquitetura, assim como permite à pesquisa ser relacionada com outros projetos, contribuindo na formação de estudantes, arquitetos e pesquisadores em práticas projetuais no ateliê de arquitetura.
Uso de coleiras impregnadas com deltametrina 4% em cães no controle da leishmaniose visceral
Authors:   , Kazimoto Thais Aparecida
Published: January 2025

A leishmaniose visceral (LV) é uma doença crônica potencialmente fatal quando não tratada. No Brasil, é causada pelo protozoário Leishmania infantum é transmitida principalmente pelo flebotomíneo Lutzomyia longipalpis, tendo o cão como principal reservatório urbano. O controle desta afecção tem consistido em um desafio para a Saúde Pública, e como proposta de medida de controle da LV canina tem-se a utilização de coleiras impregnadas com deltametrina a 4% em cães. Assim, a pesquisa tem como objetivo avaliar a efetividade dessas coleiras sobre a prevalência da LV canina e taxa de infecção de flebotomíneos para L. infantum em áreas endêmicas para LV. A pesquisa foi realizada em duas áreas equidistantes do município de Mossoró/RN com características ambientais semelhantes. Em ambas as áreas foram realizados dois inquéritos sorológicos caninos semestrais e a pesquisa de flebotomíneos. Na Área Controle (AC) foram realizados os procedimentos anteriormente citados e na Área Encoleiramento (AE) foram também realizados dois encoleiramentos caninos com coleiras impregnadas com deltametrina a 4% que ocorreram a cada seis meses. Para diagnóstico da LV canina foram realizados o teste rápido DPP e ELISA. A análise da prevalência da LV canina foi realizada através do teste de Qui-quadrado e da taxa de incidência através do Odds ratio. A pesquisa de flebotomíneos teve duração de um ano em três residências de cada uma das áreas. Os insetos foram coletados mensalmente utilizando armadilhas luminosas tipo CDC e separados por espécie, sexo, primeiro ou segundo inquérito e área da pesquisa. Foi realizada a identificação morfológica dos flebotomíneos e as fêmeas foram submetidas à técnica de PCR em tempo real para a detecção de DNA de L. infantum. Com relação às taxas de prevalência e incidência da LV canina, avaliando-se as áreas isoladamente, pôde-se observar que o uso das coleiras foi capaz de reduzir a prevalência da doença na AE e reduzir em 53 a 59% o risco de adoecimento. Quanto aos flebotomíneos, foram coletadas as espécies L. longipalpis, Lutzomyia evandroi, Lutzomyia cortelezzii e Lutzomyia migonei, sendo que 81,8% destes insetos eram L. longipalpis. Foram obtidos pools positivos de L. longipalpis da AE somente durante o primeiro inquérito ao passo que na AC pôde-se observar a presença do DNA do parasita no vetor em ambos os inquéritos. Com base nos resultados, pode-se afirmar que a utilização de coleiras impregnadas com deltametrina a 4% reduziu a prevalência da LV canina, e permite reduzir em pelo menos 53% o risco de adoecimento. Também é possível sugerir que o uso contínuo destas coleiras pode ter o potencial de reduzir a taxa de flebotomíneos infectados. Dessa forma, coleiras impregnadas com deltametrina a 4% podem ser indicadas como medida de controle para a LV canina, aliada as demais medidas atualmente preconizadas.