bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Non-invasive Method Allowing for Discovery of Pathologically Relevant Proteins From Small Airways
Authors: Östling Jörgen , Geest Marleen Van , Olsson Henric K , Dahlen Sven-Erik , Viklund Emilia , Gustafsson Per M. , Mirgorodskaya Ekaterina , Olin Anna-Carin
Published: December 2021

BackgroundThere is a lack of early and precise biomarkers for personalized respiratory medicine. Breath contains an aerosol of droplet particles, which are formed from the epithelial lining fluid when the small airways close and re-open during inhalation succeeding a full expiration. These particles can be collected by impaction using the PExA® method (Particles in Exhaled Air), and are derived from an area of high clinical interest previously difficult to access, making them a potential source of biomarkers reflecting pathological processes in the small airways.Research questionOur aim was to investigate if PExA method is useful for discovery of biomarkers that reflect pathology of small airways.Methods and analysis10 healthy controls and 20 subjects with asthma, of whom 10 with small airway involvement as indicated by a high lung clearance index (LCI ≥2.9 z-score), were examined in a cross-sectional design, using the PExA instrument. The samples were analysed with the SOMAscan proteomics platform (SomaLogic Inc). ResultsTwo hundred-seven proteins were detected in up to 80% of the samples. Nine proteins showed differential abundance in subjects with asthma and high LCI as compared to healthy controls. Two of these were less abundant (ALDOA4, C4), and seven more abundant (FIGF, SERPINA1, CD93, CCL18, F10, IgM, IL1RAP). sRAGE levels were lower in ex-smokers (n=14) than in never smokers (n=16). Gene Ontology (GO) annotation database analyses revealed that the PEx proteome is enriched in extracellular proteins associated with extracellular exosome-vesicles and innate immunity.ConclusionThe applied analytical method was reproducible and allowed identification of pathologically interesting proteins in PEx samples from asthmatic subjects with high LCI. The results suggest that PEx based proteomics is a novel and promising approach to study respiratory diseases with small airway involvement.
Intrasellar Arachnoid Cyst, a Rare Radiological Finding: Report of a Case.
Authors: Rodriguez Alejandro Augusto Ortega , Cardera José Luís Caro , Muñoz Jordi de Manuel-Rimbau
Published: December 2021

Intrasellar arachnoid cysts are uncommon radiological findings, generally incidental and clinically silent. We present the case of 70 year-old female who was treated of meningitis due to cerebrospinal fluid nasal fistulae. She was diagnosed of intrasellar arachnoid cyst and managed conservatively because no neurologic, hormonal, symptomatic either CSF fistulae appeared during follow-up. The origin of intrasellar arachnoid cysts is unclear; although an incomplete diaphragma sellae through basal arachnoid membrane herniates may be a plausible theory. Conservative treatment is the usual option, but if hormonal, visual or intracranial hypertension symptoms appeared, surgery may be the best therapy. This entity should be in the differential diagnosis of cystic sellar lesions with other benign cysts and tumors as craniopharyngioma.
Metabolic Activity Via 18 F-FDG PET/CT is Predictive of Microsatellite Instability Status In Colorectal Cancer
Authors: Song Jinling , Wei Maomao , Wang Xuejuan
Published: December 2021

Purpose: Identification of microsatellite instability high (MSI-H) colorectal cancer (CRC) is crucial for screening patients most likely to benefit from immunotherapy. We aim to investigate whether the metabolic characteristics is related to MSI status and can be used to predict the MSI-H CRC. Methods: A retrospective analysis was conducted on 420 CRC patients who were identified via [18F]fluorodeoxyglucose (18F-FDG) positron emission tomography (PET)/computed tomography(CT) prior to therapy. Maximum standardised uptake (SUVmax), mean standardised uptake (SUVmean), metabolic tumour volume (MTV) and total lesion glycolysis (TLG) of the primary tumour were calculated and compared between MSI-H and microsatellite stability (MSS). Predictive factors of MSI status were selected from metabolic parameters and clinicopathological profiles via a multivariate analysis.Results: Of 420 colorectal cancers, 44 exhibited a high incidence of MSI. Both MTV and TLG were significantly higher in MSI-H group compared with the MSS group (P=0.004 and P=0.010, respectively). Logistic regression analysis indicated that CRC with MSI-H were related to younger age (P=0.013), primary lesion located at right hemi-colon (P<0.001) and larger MTV on PET/CT imaging (P=0.019). MTV more than 32.19 cm3 of colorectal cancer was linked to the presence of MSI (P=0.019). Conclusion: Tumor metabolic burden were higher in MSI-H CRC which may be useful for predicting the MSI status of CRC patient and thus aid in determination of immunotherapy for patients with CRC.
Effects of H19/SAHH/DNMT1 on the Oxidative DNA Damage Related to Benzo[a]Pyrene Exposure
Authors: Fu Ye , Li Xuejing , Pan Baolong , Niu Yingying , Zhang Bin , Zhao Xinyu , Nie Jisheng , Yang Jing
Published: December 2021

The mechanisms that long noncoding RNA (lncRNA) H19 binding to S-adenosylhomocysteine hydrolase (SAHH) interacted with DNA methyltransferase 1 (DNMT1) and then regulated DNA damage caused by PAHs remain unclear. A total of 146 occupational workers in a Chinese coke-oven plant in 2014 were included in the final analyses. We used high performance liquid chromatography mass spectrometry (HPLC-MS) equipped to detect urine biomarkers of PAHs exposure, including 2-hydroxynaphthalene (2-NAP), 2-hydroxyfluorene (2-FLU), 9-hydroxyphenanthrene (9-PHE), 1-hydroxypyrene (1-OHP). The levels of SAM and SAH in plasma were detected by HPLC-ultraviolet. By constructing various BEAS-2B cell models exposed to 16 µM Benzo[a]pyrene (BaP) for 24 h, toxicological parameters reflecting distinct mechanisms were evaluated. We documented that urinary 1-hydroxypyrene (1-OHP) levels were positively associated with blood H19 RNA expression (OR: 1.51, 95% CI: 1.03 - 2.19), but opposite to plasma SAHH activity (OR: 0.63, 95% CI: 0.41 - 0.98) in coke oven workers. Moreover, by constructing various BEAS-2B cell models exposed to Benzo[a]pyrene (BaP), we investigated that H19 binding to SAHH exaggerated DNMT1 expressions and activity. Suppression of H19 enhanced the interaction of SAHH and DNMT1 in BaP-treated cells, decreased OGG1 methylation, reduced oxidative DNA damage and lessened S phase arrest. However, SAHH or DNMT1 single knockdown and SAHH/DNMT1 double knockdown showed the opposite trend. A H19/SAHH/DNMT1 axis was involved in OGG1 methylation, oxidative DNA damage and cell cycle arrest by carcinogen BaP.
Respiratory Viruses Among Ethnic Nicobarese During COVID-19 Pandemic
Authors: Muruganandam Nagarajan , Roy Avijit , Sivanandan Nimisha , Vins Alwin , Beniwal Nisha , Potdar Varsha , Parvez Rehnuma
Published: December 2021

Background: Acute respiratory infections (ARIs) and severe acute respiratory illness (SARI) are public health burdens globally. The percentage of non-SARS CoV-2 respiratory viruses among patients having ARI and SARI who visit Car Nicobar's hospital settings is undocumented. Changes in the epidemiology of other respiratory viruses during COVID19 pandemic is being reported worldwide.Methods: Inpatient and outpatient settings at BJR hospital, Car Nicobar Island, India, were used to conduct prospective monitoring for ARI and SARI among Nicobarese tribal members. The patients with ARI and SARI were enlisted in BJR hospital from June 2019 to May 2021. At the ICMR-NIV in Pune, duplex qRTPCR assays were used to test the presence of respiratory viruses. The prevalence of non- SARS CoV-2 respiratory viruses was measured by comparing here between pandemic and pre-pandemic periods.Results: During the COVID19 pandemic, Influenza A (H3N2) (55.7%), and rhinovirus (12.5%) were predominantly reported non-SARS CoV-2 respiratory viruses while Human metapneumovirus (48.1%) and influenza A (H1N1)pdm09 (18.5%) were most commonly reported in the prepandemic period. This result indicates the altered circulation of non-SARS CoV-2 during pandemic.Conclusions: A considerable proportion of respiratory infection was correlated with respiratory viruses. Prevalence of non-SARS CoV-2 respiratory viruses was high at the time of infection when compared with pre-pandemic period, at Car Nicobar Island. This study enlightened the change in circulation of other respiratory viruses among the indigenous Nicobarese tribes. Clinicians and allied medical staff should be more prudent of these respiratory infections.
Konzeptdialoge als Instrument inklusiver Diagnostik? Erfassung kindlicher Präkonzepte, Vorstellungen und Begründungen im Problemlöseprozess – am Beispiel zum Phänomen Stabilität von Brücken
Authors: Hormann Kathrin , Quittkat Laisa M. , Schomaker Claudia
Published: December 2021

Im Rahmen des Beitrages werden Ergebnisse aus der Analyse von Interviews mit Kindern auf Basis eines Konzeptdialogs zum Phänomen Stabilität von Brücken vorgestellt. Fokussiert werden dabei die kindlichen Präkonzepte und Vorstellungen zu diesem Phänomen sowie die Begründungen, die die Kinder zur Lösung der Problemstellung Bau einer Brücke aus Papier vornehmen. Anknüpfend an diese Ergebnisse werden – im Sinne einer inklusiven Diagnostik – unterschiedliche Lernvoraussetzungen abgeleitet sowie die sich daraus ergebenden Anknüpfungspunkte und Erweiterungen für einen inklusiven Sachunterricht vorgestellt. Abschließend wird auf Basis der Ergebnisse diskutiert, welche Schlussfolgerungen für die Qualifizierung von Lehrkräften gezogen werden können, um so zu einem differenzierteren Verständnis inklusiver Diagnostik beitragen zu können.
 
Abstract
As part of the contribution, results from the analysis of interviews with children on the basis of a conceptual dialogue on the phenomenon of bridging stability are presented. The focus is on the childlike preconceptions and ideas about this phenomenon, as well as the reasons the children give to solve the problem of building a bridge out of paper. Based on these results – in the sense of an inclusive diagnosis – different learning prerequisites are derived and the resulting connecting point and extensions for an inclusive Sachunterricht are presented. Finally, on the basis of the results, it is discussed which conclusions can be drawn for the qualification of teachers in order to contribute to a more differentiated understanding of inclusive diagnostics.
Media Edukasi Berbasis Web Sebagai Upaya Pendukung Pendidikan Karakter Berdasar nilai Kearifan Lokal Pada Pusat Pengembangan Anak Light Generation
Authors: Pitaloka Gabriela Brissa , Sophie Simfony , Melani Veronika Verasita , Kristantyo Yogi Evan Dwi , Siang Jong Jek
Published: December 2021

PPA Light Generation is one of the Compassion Foundations under the Pentecostal Church in Indonesia Hagios Family Yogyakarta which helps children with poor backgrounds. There are approximately 200 children from various Tribes, Religions, Races, and Intergroups from the age of 1 to 22 years who are sheltered by PPA Light Generation. The form of learning activities focuses on the formation of character and personality in children who are guided by noble values. In addition, the skills and talents of each fostered child are also considered. Coaching involves fostered children and mentors which is carried out regularly every week in the church. However, since the Covid-19 pandemic, physical meetings and material sharing cannot be carried out. The service output is "Edugen" learning management system that can be used by mentors and fostered children. The aim is to facilitate the learning process both in terms of delivering material and communication between mentors and fostered children and to support access to the dissemination of local wisdom values in PPA Light Generation so that by strengthening the value of local wisdom the fostered children can fortify themselves from negative influences. The method used is in the form of socialization, training and assistance in technology, which is carried out online and offline by complying with health protocols. The training and assistance provided is in the form of materials on how to use the Edugen website for mentors and fostered children. The implementation of the activity was successful with an average score of more than 70%.
A Novel Approach for Diagnosis of Diabetes Using Iris Image Processing Technique and Evaluation Parameters
Authors: Jagtap Shilpa , Mudegaonkar J L , Patil Sanjay , Bhoyar Dinesh
Published: December 2021

This paper presented here deals with study of identification and verification approach of Diabetes based on human iris pattern. In the pre-processing of this work, region of interest according to color (ROI) concept is used for iris localization, Dougman's rubber sheet model is used for normalization and Circular Hough Transform can be used for pupil and boundary detection. To extract features, Gabor Filter, Histogram of Oriented Gradients, five level decomposition of wavelet transforms likeHaar, db2, db4, bior 2.2, bior6.8 waveletscan be used. Binary coding scheme binaries’ the feature vector coefficients and classifier like hamming distance, Support Vector Machine (SVM), Adaptive Boosting (AdaBoost), Neural Networks (NN), Random Forest (RF) and Linear Discriminative Analysis (LDA) with shrinkage parametercan be used for template matching. Performance parameters such as Computational time, Hamming distance variation, False Acceptance Rate (FAR), False Rejection Rate (FRR), Accuracy, and Match ratio can be calculated for the comparison purpose.
Brick Manufacturing Machine
Authors: Jadhav Chetan C , Kadam Nilesh Sanjay , Khote Abhijeet Sunil , Patil Santosh Hanamant , Pansare Akshay Balasaheb , Wangikar Sandeep S
Published: December 2021

In past time people are building different structure by stone, soil, lime, wood etc. But as time passes, they improve themselves and they started constructing different kinds of construction by using bricks. They preparing those bricks by hands only, it is suitable for less number of bricks but for bulk amount of bricks lot of errors occurs and also high man power is required, this process is time consuming so to avoid this problem machine is required. Whatever machines are present in market is so much expensive. After understanding this problem, we prepared less costly brick manufacturing machine. This project is consisted of motor, meshed gears, input material storage, extruder inclined bed.
Función de la impulsividad en el trastorno por consumo de sustancias
Authors: Méndez Díaz Mónica , Rangel Rangel Diana Alejandra , Alvarado Ramírez Yalitza Azucena , Mendoza-Méndez Aline , Herrera Solís Andrea Mónica , Cortes Morelos Jaqueline , Ruiz-Contreras Alejandra Evelyn , Prospéro-García Oscar
Published: December 2021

La proporción de usuarios de una sustancia de abuso que desarrolla problemas con su consumo (abuso o dependencia) representa solo una parte de esta población. En México, el 63.8 % de la población consume alcohol, y de ellos, el 15 % desarrolla algún trastorno por consumo de alcohol (TCA). Se ha observado una relación causal entre el trastorno por consumo de sustancias (TCS) y la falta de autocontrol. Es decir, satisfacer necesidades de manera impulsiva, v. gr., consumir una droga sin evaluar las consecuencias. La corteza prefrontal (CPF) es el principal sustrato neuroanatómico del autocontrol y característicamente la CPF alcanza la madurez alrededor de los 30 años, sugiriendo que el autocontrol se alcanza despues de esta edad. Se ha propuesto que todos los grupos etarios que no han consolidado el uso del autocontrol son vulnerables al TCS. Similarmente ocurre con aquellos sujetos que por algún trastorno psiquiátrico tienen como característica una limitada función prefrontal. La CPF coordina una red subcortical cuya interacción depende de distintos sistemas de neurotransmisión, entre ellos, endocanabinoides. En este trabajo se revisó la función de la CPF y del sistema de endocanabinoides (sECB) y su relación con la vulnerabilidad a la adicción y otros trastornos psiquiátricos.

Palabras clave: Impulsividad, autocontrol, transtorno por uso de sustancias, enfermedades psiquiátricas.
Developing corporate social responsibility in the face of the COVID-19 pandemic
Authors: Riabets Nataliia
Published: December 2021

The paper presents the results of the study of the manifestations, trends of business social responsibility during the pandemic and gives the dominant directions of its practical implementation. The paper provides the results of the analysis of the evolutionary development of views and approaches to theoretical and conceptual understanding of corporate social responsibility. The impact of business social responsibility on the results of its activities and the quality of relationships with stakeholders is revealed. A study was also conducted on the transformation of directions and tools for the practical implementation of CSR initiatives before and during the spread of the pandemic. Potential directions for establishing a constructive conversation business structure with society, which will have a positive impact on the success and stability of the business, as well as on social development in the current environment have been identified. A study was carried out to evaluate the perception of the social responsibility by domestic business organizations and awareness of its trends, and the need for its implementation and advantages. A comparative analysis of the development of corporate social responsibility in the world and in Ukraine has been conducted. Trends and mechanisms that have a transformational impact on the formation and implementation of CSR in modern conditions of development are identified. The priority vectors of CSR programs of international business entities in the face of a pandemic are outlined. The necessity of developing a business process management model based on corporate and social responsibility tools has been formulated, taking into account the desire of business to conduct successful activities in a highly dynamic global environment.
Deneysel overyan iskemi/reperfüzyon modelinde iloprostun uzak organ olarak karaciğer dokusu üzerindeki koruyucu etkisi
Authors: DURAN Mehmet , YILMAZ Nezir , ANNAÇ Ebru , DOĞUKAN Mevlüt
Published: December 2021

Amaç: Bu deneysel çalışmada iloprostun karaciğer dokusu üzerindeki koruyucu etkisini bir iskemi/reperfüzyon (İ/R) sıçan modelinde araştırmak amaçlanmıştır.Yöntem: Toplam 32 adet dişi Sprague–Dawley sıçan, 4 eşit gruba ayrıldı. Grup 1’deki sıçanlarda overyan dokulara herhangi bir cerrahi işlem uygulanmadı. Sırasıyla Grup 2, 3 ve 4’teki overyan dokulara ise 3 saatlik torsiyon, 3 saatlik torsiyon + 3 saatlik detorsiyon, ve 3 saatlik torsiyon + 3 saatlik detorsiyon + 60 dakikalık iloprost infüzyonu uygulandı. Dokulardan 7 μm kalınlıkta kesitler alındı, hematoksilen–eozin, Masson trikrom ve toluidin mavisi ile boyandı. Kesitler üzerinde ışık mikroskobik inceleme yapıldı.Bulgular: Grup 2, 3 ve 4’te Grup 1’e kıyasla sinüzoidal dilatasyon ve vasküler konjesyonda istatistiksel olarak anlamlı artış tespit edildi (p<0,05). Grup 4’te diğer gruplara kıyasla daha fazla sinüzoidal dilatasyon ve vasküler konjesyon görüldü. Yine Grup 2, 3 ve 4’te Grup 1’e kıyasla daha fazla enflamasyon, fibrozis, hemoraji ve daha yüksek mast hücre yoğunluğu tespit edildi. Ancak fark istatistiksel olarak anlamlı değildi (p>0,05). Histopatolojik skorlamada Grup 2 ve 4’te benzer, Grup 3’te ise daha yüksek skorlar gözlendi.Sonuç: İloprostun İ/R hasarına karşı karaciğer dokusu üzerinde koruyucu etkileri olduğu sonucuna varılmıştır.
A Dança na Universidade
Authors: Vieira Marcilio
Published: December 2021

O texto faz uma reflexão sobre os cursos de Licenciatura em Dança da região nordeste do Brasil. Apresenta algumas considerações acerca do currículo de tais cursos fazendo uma aproximação e distanciamento dos mesmos. Para tal empreendimento foi feita uma busca no site do Ministério da Educação e Cultura (MEC) para localizar em quais universidades públicas brasileira da referida região encontravam-se esses cursos de Licenciatura em Dança.
PREZADX, ESPELHO-DIFUSO-LEITORX
Authors: Ferreira Natã , Ciotti Naira
Published: December 2021

Esse lugar [AQUI] feito de palavras-imagens é uma carta para leitorxs, um convite para enxergarmos algum reflexo nesse espelho-difuso-nós. [Aqui] trago a performance arte como um meio de construirmos lugares outros, rompendo com as padronizações compulsórias. Passaremos por Questões Muitas e Respostas Raras, Maneiras Outras de Ser Afetadx e por Meios de Não Nos Abandonarmos. [Aqui] através desse diálogo entre um Eu que se dilui em Você que lê, proponho formarmos Nós de uma rede de afetos. E assim pensarmos a ação Guiado Pela Multidão feita no evento Reperformar o Afeto: Professores-Performers (UFRN) em 2018.
El patrono escolar y la identidad nacional
Authors: Montenegro Ana María
Published: December 2021

Esta presentación da cuenta de avances de un proyecto de investigación que tiene como objetivo discernir la relevancia que para la representación supuso /pone nominar la escuela pública con un patrono escolar. Aunque ya en el siglo XVIII era usual que las escuelas de Buenos Aires estuvieran bajo la protección de un “patronus”, después de la Independencia esta tendencia muta, pero es entre mediados del XIX y del XX cunado bajo diversos paradigmas estatales el acto de nominar se tensiona. Aunque la bandera y el escudo nacional tuvieron consenso para representar al estado, nominar con un patrono va al meollo de la identidad nacional y queda entrecruzado por tensiones gubernamentales, historiográficas y de doctrina partidaria, que se visibilizan desde convivencias, olvidos, querellas y silencios.
Educación religiosa y regulaciones del cuerpo
Authors: Maciel María Magdalena
Published: December 2021

Este trabajo analiza las relaciones entre el discurso pedagógico-religioso de una de las instituciones educativas más importantes orientadas a la formación de niñas y jóvenes en Salta hacia fines del siglo XIX -el Colegio Sagrado Corazón- y su inscripción en los cuerpos de las educandas en vistas a su regulación. Para ello se rastrean los discursos referidos a las mujeres, presentes en diferentes fuentes (reglamentos escolares, manuales, normativas, entre otras). El análisis de las fuentes  diálogo con las condiciones de producción de las mimas, por lo que se tendrá en cuenta quiénes lo produjeron; el contexto social, cultural, eclesiástico, económico y político; junto a otros elementos significativos.
Análise de impressos no Brasil Império
Authors: Albuquerque Suzana Lopes
Published: December 2021

Esse trabalho visa compreender o Ensino Universal apresentado na Filosofia Panecástica do francês Joseph Jacotot (1770-1840) a partir da análise de diferentes impressos brasileiros no século XIX. A análise será fundamentada em autores como Boto (2012; 2016; 2017), Boto & Albuquerque (2016, 2017), Rancière (2015) e Raisky (2012). No trabalho com as fontes, serão utilizados documentos avulsos da instrução pública (1855-1857), relatórios da Instrução Pública (1850-1860), periódico SCIENCIA, dentre outros. Conflitos, tensões, acordos, discriminações, satisfações, disputas e rejeições engendraram-se à história desses intelectuais.
Historiografia Educacional no Brasil
Authors: Souza Sauloeber Tarsio de
Published: December 2021

O artigo busca traçar um panorama da produção científica veiculada na década inicial da Revista História da Educação (ASPHE, 1997) e dos Cadernos de História da Educação (UFU, 2002), fomentando a reflexão em torno da historiografia da educação no Brasil. Esses periódicos surgiram em instituições do interior do país, destacando-se o pioneirismo da RHE, contudo, ambas se constituíram em importantes canais de comunicação do conhecimento da área, contando entre seus editores com pesquisadores de mérito. A análise dos dados foi apoiada na tabulação do conjunto de 180 artigos publicados na RHE e nos 207 artigos veiculados pela CHE. Os resultados apontaram peculiaridades e aproximações entre essas revistas, que em seus primeiros momentos circulavam no formato impresso, destacando-se, por exemplo, diferenças entre os grupos temáticos predominantes constantes nos artigos veiculados.
A Novel Approach for Designing Electrochemical Aptamer-Based
Biosensor for Ultrasensitive Detection of Zearalenone as a Prevalent
Estrogenic Mycotoxin
Authors: Hassani Shokoufeh , Maghsoudi Armin Salek , Akmal Milad Rezaei , Shoeibi Shahram , Ghadipasha Fatemeh , Mousavi Taraneh , Ganjali Mohammad Reza , Hosseini Rohollah , Abdollahi Mohammad
Published: December 2021

Background:

Zearalenone is a well-known estrogenic mycotoxin produced by
Fusarium species, a serious threat to the agricultural and food industries worldwide.
Zearalenone, with its known metabolites, is a biomarker of exposure to certain fungi, primarily
through food. It has considerable toxic effects on biological systems due to its carcinogenicity,
mutagenicity, renal toxicity, teratogenicity, and immunotoxicity.

Introduction:

This study aims to design a simple, quick, precise, and cost-effective
method on a biosensor platform to evaluate the low levels of this toxin in foodstuffs and
agricultural products.

Methods:

An aptamer-based electrochemical biosensor was introduced that utilizes
screen-printed gold electrodes instead of conventional electrodes. The electrodeposition
process was employed to develop a gold nanoparticle-modified surface to enhance the
electroactive surface area. Thiolated aptamers were immobilized on the surface of gold
nanoparticles, and subsequently, the blocker and analyte were added to the modified surface.
In the presence of a redox probe, electrochemical characterization of differential
pulse voltammetry, cyclic voltammetry, and electrochemical impedance spectroscopy
were used to investigate the various stages of aptasensor fabrication.

Results:

The proposed aptasensor for zearalenone concentration had a wide linear dynamic
range covering the 0.5 pg/mL to 100 ng/mL with a 0.14 pg/mL detection limit. Moreover,
this aptasensor had high specificity so that a non-specific analyte cannot negatively
affect the selectivity of the aptasensor.

Conclusion:

Overall, due to its simple design, high sensitivity, and fast performance, this
aptasensor showed a high potential for assessing zearalenone in real samples, providing a
clear perspective for designing a portable and cost-effective device.
Experiences of Motherhood in University Students in Brazil: A Qualitative Study
Authors: Amorim Fernanda , Maia Brunna , Melo Valéria , Almeida Camila , Magalhães Juliana , Carvalho Claudia , Viana Magda , Veras Juscélia , Mendes Cíntia , Damasceno Carolinne
Published: December 2021

Introduction:

The women’s rise to higher education contrasts with the phenomenon of motherhood, since it instigates changes in various contexts, whether physiological or emotional, and directly affects the way of life and routine of those women, resulting in a constant conflict between motherhood and academic career. In this sense, the student has to restructure responsibilities and behaviors, as well as requires family support and laws that support her in this period.

Objectives:

To describe the experiences of motherhood in university students, and to identify the strategies developed by university students to adapt motherhood with academic routine.

Methods:

This is a descriptive, exploratory and qualitative research carried out in a private University Center in Brazil. The participants were ten Nursing undergraduate students, regularly enrolled and who experienced motherhood during the academic term. Data were collected during August and September 2019, through a recorded interview using a semi-structured form. For the treatment and analysis of the data, the Collective Subject Discourse was used. The study followed the ethical precepts and was approved by the ethics committee (opinion n. 3.419.572).

Results:

The participants’ discourses gave rise to four central ideas: Feelings experienced from the discovery of pregnancy; The discovery of pregnancy and the decision to continue the course; Support relationships as a decisive factor for the non-abandonment of the course and Strategies to reconcile motherhood with academic routine. The main key expressions identified in the discourses were: joy, fear, insecurity, anguish, concern, distress, anger, sadness, interrupting, giving up, taking time off from the course, not taking time off from the course, family support, support from friends, support from the institution, adjusting schedules, studying while my child sleeps, family help, taking the baby to college, storing milk while breastfeeding.

Conclusion:

The analysis of the discourses revealed that the experience of motherhood in the university sphere is marked by a combination of different feelings, and by an important process of adaptations to the new moment, since there is a reflection and indecision about the continuity of the academic trajectory. The reports also highlight the importance of family, institutional and friend support, such as a support network of incentive to the care with the child, as well as the use of strategies to reconcile academic routine with motherhood.
Prescription of Antimicrobials in Primary Health Care: Scoping Review
Authors: Carvalho Herica Emilia Félix , Schneider Guilherme , dos Santos Junior Aires Garcia , Batista Odinéa Maria Amorim , Mondlane Jose , Ferreira Adriano Menis , de Andrade Denise , da Costa Valle Andreia Rodrigues Moura
Published: December 2021

Objective:

To map the available evidence about the prescription of antimicrobials in Primary Health Care.

Methods:

A Scoping Review has been proposed based on the procedures recommended by the Joanna Briggs Institute.

Results:

This review included a total of 16 studies. The articles compiled demonstrated that this theme is the center of discussion, in a linear manner, over the past 12 years. Among the studies, 37.5% occurred in Brazil, and regarding the prescription of antimicrobials analyzed in studies, amoxicillin was the most prescribed, the physician was the prescribing professional in 12 studies, and the prescriptions were mostly intended for the general population (children, adolescents, adults and the elderly).

Conclusion:

This review ratifies the premise of rational use of antimicrobials promoted by the World Health Organization through the goals of sustainable development when understanding that these drugs have been considerably prescribed in the daily routine of Primary Health Care and there is no specific system to control and monitor their rational use.
Coordenações assimétricas no português antigo
Authors: Salvi Giampaolo
Published: December 2021

This paper takes into account some asymmetries found in Medieval Portuguese coordinate structures containing infinitival clauses. These are cases of coordination of a non-inflected infinitive with an inflected one and cases of apparent extraction of an element from the first clause of a coordinate structure. Both asymmetries can be eliminated if we assume that the coordination takes place at a higher structural level than that of the infinitival clauses; however, this solution entails that we have to postulate a gap in the second conjunct with the ellipsis of some elements (and/or the presence of some abstract elements) recoverable on the basis of elements expressed in the first conjunct. We show that only this more abstract hypothesis can explain in a direct manner the data examined in this work.
Greek derivational affixes roots or categorizers?
Authors: Alexiadou Artemis
Published: December 2021

In this paper, I am concerned with the status of derivational affixes in Distributed Morphology: are these roots or categorizers? I will compare Greek to English and Dutch, as some derivational affixes in these two languages have been claimed to be roots. I will show that Greek derivational affixes are categorizers, and I will offer an explanation that capitalizes on the stress properties of Greek derivational affixes.
Potential Activated Carbon of Theobroma cacao L. Shell for Pool Water Purification in Politeknik Negeri Padang
Authors: Yetri Yuli
Published: December 2021

Research has been carried out to improve the quality of the yellow pool water. The water is used as a source of clean water for the academics of the Politeknik Negeri Padang, so it needs to be improved in accordance with the quality standards of clean water, and is suitable for daily use. The adsorption process was carried out using activated carbon of Theobroma cacao L. shells which was carbonated at 400oC for 1 hour and activated with H3PO4. Characterization of functional groups using Frontier Transform Infra Red (FTIR), and morphology of surface  using Scanning Electron Microscopy (SEM). The quality of clean water standard analyzed is turbidity, Total Dissolved Solids (TDS), color, Total Suspended Solids (TSS), and Fe content. Functional group analysis exhibits that the activated carbon produced has a pattern of absorption with O-H, C-H, and C-O bond types. At the optimum condition of the activation process, a good adsorbent is absorbed in pool water purification at a flow rate of 5 mL/min with a mass of 2 grams. The analysis showed an efficiency decrease in turbidity value of 67%, Total Dissolved Solids (TDS) 71%, Color 97%, Total Suspended Solids (TSS) 86%, and Fe content 38%. Surface morphology of activated carbon showed the presence of pore cavities, and after the filtration process the cavities became saturated. This shows that there has been an absorption by activated carbon, so that the water becomes clear. Activated carbon of Theobroma cacao L.shell is very effective in the process of purifying pool water into clean water and fulfilling clean water standards, so it is suitable for  are used.
Air Pollution Dispersion Modelling using GRAL in Area Near Coal-Steam Power Plant at Central Java
Authors: Fatkhurrahman Januar Arif , Sari Ikha Rasti Julia , Andriani Yose
Published: December 2021

Sulfur dioxide and Nitrogen dioxide were significant emissions emitted from coal-steam power plants that may cause health problems for humans and damage the environment. Studying the SO2 and NO2 gradients in Indonesian residential communities is critical for evaluating resident's SO2 and NO2 exposure. The method developed to assist analysis of spatial SO2 and NO2 gradients on a community scale combines a mesoscale Lagrangian dispersion model with field observations around coal-steam power plants using GRAL. The objectives of this study focused on GRAL dispersion of SO2 and NO2 in an Indonesian residential community near the coal-steam power plant, with a 6 km x 8 km resolution. Analysis of this model indicates a correlation between simulation and observation, with SO2 coefficient correlation (R) within 0.5 – 0.82 and NO2 coefficient correlation (R) within 0.30 – 0.59. Model performances analyze by NMSE and FB. The SO2 model is comparable to observation data since it has a better average NMSE and FB than the NO2 model. Due to data limitation of observation collected by grab sampling instead of continuous ambient measurement system affect different respond time compared with hourly data from the model.
Nanotebuconazole: Điều chế trong môi trường nước và khảo sát hiệu quả kháng nấm bệnh gây hại trên cây trồng
Authors: Phạm Quốc Yên , Trần Quốc Tuấn
Published: December 2021

Tebuconazole được phân tán trong hỗn hợp polyethylene glycol (PEG) và nước theo một tỉ lệ xác định với sự hiện diện của dichloromethane (DCM). Hỗn hợp sau đó được làm bay hơi ở 40oC dưới áp suất 480 mbar để loại bỏ DCM và hình thành nanotebuconazole. Kích thước hạt nanotebuconazole được xác định trong khoảng 27 – 35 nm với kích thước trung bình là 29 nm  bằng kĩ thuật tán xạ ánh sáng động (DLS) và kết quả nghiên cứu cho thấy tỉ lệ PEG:H2O 4:1 là thuận lợi nhất cho quá trình hình thành hạt nhũ nano. Các thử nghiệm in vitro bằng phương pháp MIC (minimum inhibitory concentration) chứng minh rằng dạng nanotebuconazole cho hiệu quả kháng khuẩn, kháng nấm mạnh gấp 2 lần dạng thương mại trên các chủng Ralstonia solanacearum, Fusarium ambrosium và Rhizoctonia solani và gấp 4 lần trên chủng Phytophthora capsici, với nồng độ ức chế tối thiểu lần lượt là 50 ppm và 25 ppm. Chế phẩm nanotebuconazole được đánh giá chất lượng đáp ứng đầy đủ tiêu chuẩn thuốc bảo vệ thực vật theo Tiêu chuẩn Việt Nam 9482:2012 (TCVN 9482:2012).
Hoạt tính kháng oxy hóa và kháng khuẩn của cao chiết ethanol từ lá Cóc trắng (Lumnitzera racemosa Willd)
Authors: Huỳnh Kim Yến , Nguyễn Trọng Tuân , Trần Thanh Mến , Phùng Thị Hằng , Nguyễn Hoàng Sơn , Trần Hoàng Lâm , Trương Thị Tú Trân , Lê Trung Tín
Published: December 2021

Cóc trắng hay còn gọi Cọc vàng (Lumnitzera racemosa) là một loài thực vật ngập mặn với nhiều dược tính quý. Tuy nhiên, các nghiên cứu về loài cây này không nhiều, đặc biệt ở Việt Nam. Trong nghiên cứu này, thành phần hóa học cũng như hoạt tính kháng oxy hóa in vitro và hoạt tính kháng khuẩn gây bệnh trên thủy sản của cao chiết Cóc trắng đã được khảo sát. Kết quả cho thấy cao ethanol Cóc trắng có hàm lượng polyphenol và flavonid tổng được xác định lần lượt là 138,532 mg GAE/g; 182,014 mg QE/g. Kết quả khảo sát hoạt tính kháng oxy hóa cho thấy cao ethanol Cóc trắng cho hoạt tính mạnh nhất trên phương pháp thử nghiệm là ABTS●+(IC50=20,461 μg/mL), DPPH (IC50=81,734 μg/mL) và TAC (OD0,5= 86,943 μg/mL), sau đó là năng lực khử sắt (OD0,5=113,108 μg/mL). Cao chiết Cóc trắng thể hiện hoạt tính kháng đối với 4 dòng vi khuẩn Aeromonas hydrophila, Aeromonas dhakensis, Edwardsiella ictaluri, Streptococcus agalactiae với đường kính kháng khuẩn tương ứng 3,87 mm, 4,93 mm, 4,93 mm, 5,73 mm.
Khảo sát hoạt tính kháng sinh của cao chiết từ loài hải miên Petrosia (blue) sp.
Authors: Lưu Vũ Phương , Quách Kim Huỳnh Hoa , Hà Tất Toàn , Bùi Minh Phúc , Lê Minh Trí , Võ Duy An , Tôn Nữ Liên Hương
Published: December 2021

Trong số các loài hải miên của vùng biển Tây Nam Việt Nam, loài Petrosia (blue) sp. có số lượng tương đối phong phú và ít được nghiên cứu. Khảo sát hoạt tính sinh học của các cao chiết từ loài hải miên Petrosia (blue) sp. được thu gom ở độ sâu khoảng 10 m tại vùng biển Kiên Giang đã cho những thông tin hữu ích. Khi thử nghiệm kháng vi sinh vật, trong số 4 mẫu thử có 3 mẫu ức chế tốt các loài vi khuẩn Gram âm lẫn Gram dương, một loài nấm men; đó là các mẫu cao ethanol tổng, cao ethanol còn lại, cao dichloromethane, với IC50 < 40 µg/mL. Tuy nhiên, các cao của loài hải miên này không kháng oxy hóa và không có tác dụng với nấm men Candida albican.
Tính chất vận chuyển của khí điện tử hai chiều trong giếng thế SiGe/Si/SiGe dưới ảnh hưởng của nhiệt độ và từ trường
Authors: Nguyễn Thị Thúy Quỳnh , Lý Hoàng Diễm , Nguyễn Thị Quế Trinh , Phạm Tiến Phát
Published: December 2021

Nghiên cứu được thực hiện nhằm khảo sát độ linh động của khí điện tử hai chiều trong một giếng lượng tử SiGe/Si/SiGe tại nhiệt độ bất kỳ khi không có từ trường và khi bị phân cực bởi từ trường, xem xét tới hai cơ chế tán xạ: tán xạ tạp chất xa và tán xạ giao diện nhám có tính tới hiệu ứng tương quan–trao đổi và hiệu chỉnh trường cục bộ. Bên cạnh đó, sự phụ thuộc của mật độ tới hạn vào mật độ hạt tải, bề rộng giếng thế, khoảng cách lớp tạp chất, nhiệt độ và từ trường cũng được nghiên cứu. Tại nhiệt độ dưới 2 K, kết quả nghiên cứu này phù hợp với các kết quả đi trước. Các kết quả này có thể sử dụng để định hướng thực nghiệm trong việc nuôi cấy mẫu và kiểm soát nhiệt độ của hệ khi đo đạc mật độ tới hạn và thông tin về các cơ chế tán xạ trong giếng lượng tử SiGe/Si/SiGe.
Khả năng hòa tan lân và đối kháng với nấm Fusarium solani của dòng nấm Aspergillus niger H4.7 ở điều kiện phòng thí nghiệm
Authors: Châu Thị Anh Thy , Đặng Thị Yến Nhung , Nguyễn Khởi Nghĩa
Published: December 2021

Mục tiêu của nghiên cứu nhằm khảo sát khả năng hòa tan lân dưới một số điều kiện môi trường khác nhau và đối kháng với nấm bệnh Fusarium solani của dòng nấm Aspergillus niger H4.7 (H4.7) được phân lập từ đất nông nghiệp ở tỉnh Sóc Trăng ở điều kiện phòng thí nghiệm. Việc khảo sát khả năng hòa tan lân dưới các điều kiện môi trường gồm pH, nồng độ muối NaCl và các dạng lân khó tan khác (FePO4 và AlPO4) được thực hiện trong môi trường NBRIP lỏng, trong khi thí nghiệm khảo sát khả năng đối kháng của dòng nấm H4.7 với dòng nấm Fusarium solani gây bệnh hại cây trồng được thực hiện trên môi trường PDA. Kết quả nghiên cứu cho thấy dòng nấm H4.7 có khả năng hòa tan lân tốt trong môi trường nuôi cấy có pH=7, không bổ sung NaCl và hòa tan tốt các dạng lân khó tan theo thứ tự Ca3(PO4)2 > FePO4 > AlPO4. Ngoài ra, dòng nấm này còn có khả năng đối kháng tốt với dòng nấm Fusarium solani, đặc biệt ở thời điểm 5 ngày sau bố trí với hiệu suất đối kháng đạt 49,2%.
Hiệu quả của dịch trích thực vật đối với nấm Curvularia sp. gây bệnh vết nâu trên lúa
Authors: Lê Thanh Toàn , Nguyễn Nguyễn Hòa Nam
Published: December 2021

Nấm Curvularia sp. là một trong những tác nhân quan trọng gây hại tán lá và hạt lúa, làm giảm năng suất. Do đó, nghiên cứu được thực hiện nhằm tìm ra biện pháp hiệu quả, an toàn trong việc quản lí Curvularia. Kết quả khảo sát sự đa dạng bào tử và đĩa áp của các chủng nấm Curvularia ghi nhận bốn dạng bào tử hình chữ Y, hình trứng, thẳng nhọn một đầu, hình trụ đỉnh cùn; và ba dạng đĩa áp hình chùy, hình trứng, dạng xẻ thùy. Kích thước bào tử trung bình là 4,5-11,5 x 3,5-5,2 µm. Trong ba loại dịch trích gồm tỏi, húng quế, gừng với nồng độ 2%, dịch trích tỏi và gừng cho hiệu quả ức chế in vitro sự phát triển khuẩn ty nấm Curvularia sp. Tuy nhiên, dịch trích tỏi tốt hơn dịch trích gừng trong việc duy trì hiệu quả ức chế. Trong điều kiện nhà lưới, việc xử lí dịch trích tỏi tại thời điểm 1 ngày trước và sau khi lây bệnh cho hiệu quả giảm bệnh so với đối chứng, lần lượt là 86,62% và 87,97%, cao tương đương nghiệm thức đối chứng dương (150 g/L Difenoconazole + 150 g/L Propiconazole).
Thiên nhiên trong tập truyện Đất Phương Nam ngày cũ của Trần Bảo Định từ góc nhìn phê bình sinh thái
Authors: Lê Thị Nhiên
Published: December 2021

Nghiên cứu tập truyện Đất phương Nam ngày cũ của Trần Bảo Định từ lý thuyết phê bình sinh thái, bài viết trình bày sự thể hiện thiên nhiên trong mối quan hệ với tâm thức con người của tác giả. Đồng thời, thiên nhiên cũng là hình tượng nghệ thuật chứa đựng những thông điệp giàu ý nghĩa. Từ đó, bài viết chỉ ra quan niệm về thái độ, lối ứng xử của con người đối với không gian văn hóa đặc trưng của Nam bộ trong tập truyện ngắn này.
Necesidades informacionales en estudiantes de doctorado. Una mirada a instituciones de España, México y Colombia
Authors: Leon Aristizabal Maritza
Published: December 2021

Se revisa las necesidades informacionales que presentan los estudiantes de doctorado con relación a su proyecto de tesis doctoral, áreas de investigación y sociedad global de la información. Para este fin, se recabaron datos cuantitativos a través de un cuestionario sobre la autopercepción del uso y consulta de la biblioteca en estudiantes de doctorado. Además, se recaban y comparan datos entre 15 instituciones de España, México y Colombia, datos cuantitativos presentes en las páginas web de cada institución (programas doctorales, bibliotecas y áreas de conocimiento). Los resultados reiteran la necesidad de rediseñar y ofrecer servicios a estudiantes doc- torales, toda vez que los estudiantes de doctorado por la naturaleza de sus estudios requieren acudir a más fuentes de información.
Diseño metodológico de un proceso de búsqueda y recuperación en fuentes de información
Authors: Vargas Echeverría Shilia Lisset , Flores Escalante Oscar Alberto
Published: December 2021

El proceso de búsqueda y recuperación es un proceso articulado y retroalimentado que se inicia cuando una persona tiene un problema que requiere resolver mediante la obtención de cierta información y termina cuando resuelve dicho problema, a través de la identificación y localización de los documentos que contienen la información pertinente, logrando satisfacer su necesidad. El presente artículo tiene como objetivo elaborar un diseño metodológico sobre el proceso de búsqueda y recuperación de fuentes de información a usuarios del Centro de Documentación en Salud (CDS) del Hospital General de Zona (HGZ) No. 57. Para lograrlo se analizaron y procesaron 83 solicitudes de usuarios que hicieron uso de dicho servicio, durante el período agosto-diciembre del 2019. Los resultados obtenidos permitieron confirmar que el servicio de búsqueda y referencia es un gran apoyo para estudiantes y profesionales de la salud. El poder complementarlo con la metodología propuesta, permitió mejorar la calidad servicio en favor de sus usuarios.
Explosive and thermochemical treatment of multi-layer metallic composites
Authors: Nowaczewski Jerzy , Kita Milena , Świeczak Justyna , Rudnicki Jacek
Published: December 2021

The paper describes methods for the explosive hardening of metals which were performed with a view to increasing the hardness of previously obtained composites, as well as treatment of their surface layers to increase the efficiency of further thermochemical treatment. Typical systems for explosive hardening of metals and the construction of current systems, are discussed. The resulting effects of explosive hardening are illustrated with before and after diagrams of microhardness distributions in cross-sections of the processed composites hardening. In a further processing stage, the tested composite samples were subjected to ion nitriding. As a result of this process, in addition to the typical increase in hardness of the individual layers, an intermediate phase with a distinctly higher hardness was observed in the junction zone. Preliminary analysis of the photographs and the results from a scanning electron microscope (SEM) with an energy dispersive spectroscopy (EDS) attachment suggests that the particularly beneficial properties of the composites are attributed to the presence of the intermetallic layer.
Unmanned vehicles – a new challenge for explosive materials. An overview
Authors: Sałaciński Tomasz
Published: December 2021

The diversity of currently employed unmanned vehicles (UVs) in outer space, flying, driving and walking on land, as well as operating in water (on the surface or underwater) is presented. Examples of applications of national UVs for purposes other than military ones, are shown. It is pointed out that in each of these areas there exist armed UVs as well as ones potentially capable of carrying and deploying offensive weaponry. Trends in the development of UVs for military and commercial applications are described.
Study of the effect the rate of addition of the antisolvent on the crystallization of the CL-20
Authors: Szczygielska Joanna , Maksimowski Paweł , Skupiński Wincenty
Published: December 2021

In this paper, the effect of antisolvent addition rate on the yield and polymorphic purity of the obtained product, in order to optimise the 2,4,6,8,10,12-hexanitro-2,4,6,8,10,12-hexaazaisowurtzitane (CL-20) precipitation process using a solvent/antisolvent system, was determined. It was found that increased dispensing rate of the antisolvent results in increased supersaturation in the mother liquor. This, in turn, increases the nucleation rate. The prevalence of the process of creating new seeds reduces the growth rate of the crystal, which affects the size distribution of the final crystallisation product. Reducing the time of the process results in the transformation of the initially formed, kinetically stable polymorph β, into the thermodynamically stable ε form with a lower yield, than the yield obtained after increased time.