bluuebunny/crossref_metadata_2025 huggingface dataset:
Silent Threat: Internal Carotid Artery Hypoplasia and Its Role in Basilar Artery Aneurysm Formation – a Case Study
Authors: Mežvinska Paula , Brokāns Artis , Pavlovičs Sergejs , Dravnieks Matiss , Balodis Arturs
Published: January 2025

Background: Hypoplasia of the internal carotid artery (ICA) is a rare vascular anomaly, with an estimated incidence of less than 0.01%. This condition can result in reduced blood flow to the anterior circulation, often compensated by collateral circulation. Although frequently asymptomatic, ICA hypoplasia (ICAH) predisposes individuals to cerebrovascular events, such as aneurysms, ischemic attacks and subarachnoid hemorrhage (SAH). Radiological imaging, particularly CT angiography (CTA) and digital subtraction angiography (DSA), plays a crucial role in diagnosing this condition, revealing structural abnormalities in the arterial system. Early detection through advanced imaging is essential for preventing severe complications. Case description: This case is about a 75-year-old woman who lived her entire life unaware of ICAH until a basilar artery aneurysm ruptured, leading to a large, centrally localized SAH. Further diagnostic workup, including CTA and DSA, confirmed left ICA hypoplasia, with the artery terminating as the ophthalmic artery, along with a developmental anomaly of the left middle cerebral artery from posterior circulation territory. Due to the high risk associated with surgical and endovascular intervention, conservative management was pursued, and the patient’s condition stabilized, though she continued to have significant neurological deficits. Conclusions: This report emphasizes the rare occurrence of ICA hypoplasia and its correlation with vascular anomalies, including aneurysms and developmental malformations. This case demonstrates that if ICAH is not diagnosed early, it can lead to severe complications with permanent neurological deficits. It highlights the critical importance of advanced imaging techniques, such as CTA and DSA, in diagnosing complex vascular conditions.
Management of Pulmonary Arterial Hypertension. Current Strategies and Future Prospects
Authors: Sharma Munish , Paudyal Vivek , Syed Saifullah Khalid , Thapa Rubi , Kassam Nadeem , Surani Salim
Published: January 2025

Primary pulmonary hypertension (PPH), now known as pulmonary arterial hypertension (PAH), has envisioned significant treatment breakthroughs in the past decade. Treatment has focused on improving patient survival and quality of life and delaying disease progression. Current therapies are categorized based on targeting different pathways known to contribute to PAH, including endothelin receptor antagonists (ERAs), phosphodiesterase-5 inhibitors (PDE-5 inhibitors), prostacyclin analogs, soluble guanylate cyclase stimulators, activin signaling inhibitors as Sotatercept. The latest addition to treatment options is soluble guanylate cyclase stimulators, such as Riociguat, which directly stimulates the nitric oxide pathway, facilitating vasodilation. Looking to the future, advancements in PAH treatment focus on precision medicine involving the sub-stratification of patients through a deep characterization of altered Transforming Growth Factor- β(TGF-β) signaling and molecular therapies. Gene therapy, targeting specific genetic mutations linked to PAH, and cell-based therapies, such as mesenchymal stem cells, are under investigation. Novel pharmacologic targets are also developing, including growth factors and inflammation-modulating pathways. Ongoing clinical trials aim to refine these emerging treatments and better understand their long-term benefits and safety profiles. This review will discuss the current therapies that help delay the progression and improve survival and future PAH treatments that hold potential for curative approaches targeting underlying disease mechanisms.
Potentials-Based Computer Modelling of Lanthanide Doped Mixed Metal Fluorides and Oxides for Optical Applications
Authors: Jackson Robert Adam
Published: January 2025

This article presents a review of the field of potentials-based computer modelling as applied to the doping by lanthanides, of a range of metal oxides and fluorides, with a view to enhancing various properties for optical applications. The following host compounds are considered: BaLiF3, BaY2F8, SrAl2O4 and LiNbO3.
Taxonomic Revision of the Relationship Between Coproptilia and Nosphistica (Lepidoptera: Lecithoceridae), with Descriptions of Two New Species and a New Record from China
Authors: Li Haotian , Yu Shuai
Published: January 2025

The family Lecithoceridae represents one of the most diverse yet understudied groups within Lepidoptera, with numerous unresolved taxonomic issues requiring urgent attention. Among these, the genus Coproptilia Snellen, a small genus within Lecithoceridae, has traditionally been distinguished from its closely related genus Nosphistica Meyrick primarily by the presence of vein R1 in the forewing. However, Nosphistica exhibits considerable interspecific variation in wing venation, complicating clear differentiation between these genera. In this study, we conducted molecular phylogenetic analysis of Lecithoceridae based on a concatenated dataset of 5,350 bp, comprising one mitochondrial marker and six nuclear markers from 28 Lecithoceridae individuals. The result shows that: (1) The topological results of both Maximum Likelihood (ML) and Bayesian Inference (BI) trees show the Coproptilia branch embedded within the Nosphistica branch, so the Nosphistica Meyrick is synonymized with Coproptilia Snellen. (2) Two new species are described from China: Coproptilia uniformis Yu, sp. nov. and C. funiuensis Yu, sp. nov. (3) Coproptilia tawiensis Park, 2009 is newly recorded from China, with the first description of its female. Finally, we integrated molecular and morphological evidence to examine the taxonomic relationship between Coproptilia and Nosphistica. Additional molecular data will be needed to further clarify the subfamily affiliation of Coproptilia sensu nov..
Humeral Shaft Stress Fracture Completion in a Weight Lifter
Authors: Zhu Allen C. , Lee Cody , Strelzow Jason , Erdman Mary Kate
Published: January 2025

Case:

A 34-year-old man, amateur weight lifter presented with acute worsening of right shoulder pain after 5 months of prodromal, progressive, atraumatic pain. Imaging showed a short oblique proximal third humeral shaft fracture without evidence of other osseous abnormalities. He was treated operatively with open reduction and internal fixation, healed uneventfully, and returned to weight lifting within 3 months.

Conclusion:

Humeral shaft stress fractures most commonly occur in athletes or military personnel who engage in repetitive overhead activity. It is important to include stress fracture on the differential diagnosis for chronic pain in the upper extremity, especially in a physically active patient.
Extensor Pollicis Longus Tendon Rupture With Concomitant Electrodiagnostic and MRI Findings of Posterior Interosseous Nerve Palsy
Authors: Lin James S. , Kakar Sanjeev , Shin Alexander Y. , Bishop Allen T.
Published: January 2025

Cases:

Two patients with spontaneous loss of thumb interphalangeal joint extension were referred after history, electrodiagnostic, and/or magnetic resonance imaging (MRI) findings were felt to demonstrate a posterior interosseous nerve (PIN) palsy. Subsequent physical examination and additional directed studies suggested an alternative explanation: rupture of the extensor pollicis longus (EPL) tendon, subsequently confirmed at surgery. An extensor indicis proprius to EPL transfer restored thumb function.

Conclusion:

Electrodiagnostic and MRI changes consistent with diffuse PIN palsy may occur in the setting of EPL rupture. An accurate diagnosis of EPL dysfunction requires careful physical examination and confirmatory imaging. Further study of this previously unreported phenomenon is required.
Retained Penetrating Radiolucent Foreign Body in the First Metatarsal With a Missed Diagnosis, a Case Report
Authors: Khaled Abdullah , Hawila Ahmed Maher , Saleh Ahmed , Sadakah Mohammed
Published: January 2025

A 10-year-old boy presented with chronic medial plantar foot pain after penetrating trauma. At the time of trauma, radiographs were clear, and medications were prescribed. Two years later, radiographs showed a track of an osteolytic lesion extending to the physis of the first metatarsal. Surgical debridement and removal of the wooden foreign body were performed. At the final follow-up, he was asymptomatic. Penetrating radiolucent foreign bodies can be missed at the initial presentation and may lead to destruction of the adjacent bone and soft tissue. It requires a high index of suspicion and awareness of additional radiological modalities.
Legal Uncertainty and Barriers to Women's Representation in Village Governance
Authors: Mulyono Edy , Widodo Hananto , Rusdiana Emmilia , Prasetio Dicky Eko
Published: January 2025

Background: Women's representation in Indonesia's Village Consultative Bodies (BPD) is essential for gender equality and inclusive governance. However, unclear regulations, socio-cultural barriers, and weak enforcement hinder progress. Gap: Legal ambiguities and inconsistent practices limit effective participation and gender-responsive decision-making. Aim: This study explores the legal uncertainties affecting women's representation in BPDs and their broader impacts. Results: Findings highlight unclear legislation, gaps between national and regional regulations, and insufficient enforcement, compounded by cultural biases, reducing women’s motivation and participation. Novelty: The study provides a unique analysis of legal and socio-cultural challenges, offering actionable reform strategies. Implications: Clearer regulations and empowerment programs can improve representation, fostering equitable governance and sustainable development.
Highlights:

Legal ambiguities in regulations hinder women’s effective participation in BPDs.
Socio-cultural biases significantly reduce opportunities for gender-responsive governance.
Clearer policies and empowerment programs are vital for equitable local development.

Keywords: Women's Representation, Village Consultative Bodies, Gender Equality, Legal Uncertainty, Governance
KLASIFIKASI CITRA PNEUMONIA MENGGUNAKAN ARSITEKTUR CONVOLUTIONAL NEURAL NETWORK (CNN)
Authors: Pratama Aan Rachmatullah , Cobantoro Adi Fajaryanto
Published: January 2025

Pneumonia adalah infeksi atau peradangan akut pada bagian jaringan paru yang disebabkan oleh berbagai mikroorganisme seperti bakteri, virus, parasit, jamur, kerusakan fisik paru ataupun bahan kimia. Pneumonia dapat menyerang orang dewasa maupun anak-anak, banyak kasus yang terjadi, terutama pada Negara berkembang dimana kebanyakan mengandalkan energi yang berpontensi menyebabkan polusi udara yang akan berdampak pada pernafasan manusia. Klasifikasi citra Pneumonia dari hasil rontgen dengan algoritma Convolutional Neural Network yang memiliki metode alur pemecahan masalah yang menyerupai pola pikir manusia. Pada program ini melakukan penelitian tentang membandingkan performa dari kedua model arsitektur Convolutional Neural Network arsitektur AlexNet dengan GoogleNet. Pada hasil confusion matrix mendapatkan hasil tingkat akurasi 0,79 untuk arsitektur Alexnet dan untuk arsitektur GoogLeNet mendapatkan hasil akurasi 0,78. Umumnya akurasi dari GoogLeNet lebih tinggi namun pada penelitian ini AlexNet mendapatkan akurasi yang lebih tinggi, namun GoogLeNet memiliki loss yang lebih rendah, loss dan Accuracy diperngaruhi callback yang didalamanya terdapat epoch. Pada hasil implementasi kedua model dari web app menggunakan flask dan Google colab, dari jumlah masukan 16 citra 15 prediksi dilakukan benar dan 1 salah mendapatkan hasil akurasi 0,94.Kata kunci : AlexNet, CNN, GoogLeNet, Pneumonia
PENERAPAN ASSOCIATION RULE TERHADAP DIAGNOSA PENYAKIT MENGGUNAKAN ALGORITMA FREQUENT PATTERN GROWTH
Authors: Wahid Ach. Nur Aqil , Avianto Donny
Published: January 2025

Penumpukan data terus terjadi berbanding lurus dengan waktu, pemanfaatan data dapat digunakan dalam berbagai cara. Seperti pada umumnya, teknik asosiasi normalnya diterapkan pada sekumpulan data transaksi dengan harapan menemukan korelasi antara itemset. Namun, pada penelitian kali ini penulis ingin mencoba untuk menerapkan teknik asosiasi terhadap dataset diagnosa penyakit pada pasien umum, melihat kesamaan pola dari data yang dapat ditemukan korelasinya dengan algoritma Fp-Growth. Diharapkan hasil korelasi antara diagnosa dapat menjadi benang merah dalam pemanfaatan, penelitian, serta pengembangan untuk mencapai sebuah pembaharuan. Algoritma Frequent Pattern Growth (FP-Growth) merupakan algoritma yang sesuai untuk menentukan kumpulan data yang paling sering muncul (frekuensi itemset) dalam menganalisa korelasi antara diagnosa penyakit dari pasien, dan berikutnya hasil dari penambangan data divisualisasikan dengan basis website dengan streamlit. Dengan terus mencari hasil yang optimal dengan trial and error, dan salah hasil dari salah satu aturan terdapat pada nilai threshold 0,6 yang diterapkan pada kecamatan masa lembu mendapatkan korelasi pada aturan ketiga yaitu Neoplasma Jinak berkorelasi dengan Ileus paralitik dan obstruksi dengan nilai support 0,8 dan confidence 1. Hasil dari aturan asosiasi diharapkan dapat dikembangkan dan dapat memberikan kontribusi lebih lanjut dalam menentukan keputusan yang lebih matang.Kata kunci: Teknologi, Big Data, Penambangan Data, Association Rules FP-Growth
PEMBENTUKAN POHON KEPUTUSAN UNTUK PENERIMA BANTUAN BERAS MISKIN MENGGUNAKAN ALGORITMA DECISION TREE C4.5
Authors: Avianto Donny , Wibowo Adityo Permana
Published: January 2025

Beras Miskin (Raskin) merupakan salah satu program pemerintah yang bertujuan untuk memberikan bantuan pangan pokok kepada masyarakat kurang mampu. Namun, tantangan besar dalam implementasi program ini adalah ketidaktepatan sasaran, di mana terdapat kasus di mana warga yang seharusnya menerima bantuan malah tidak mendapatkannya, sementara sebagian yang tidak memenuhi syarat justru menerima bantuan. Penelitian ini bertujuan menghasilkan model pohon keputusan yang dapat membantu proses klasifikasi penerima bantuan beras miskin secara lebih mudah dan akurat, sehingga penyaluran program Raskin menjadi lebih tepat sasaran. Pembuatan model dilakukan menggunakan aplikasi RapidMiner Studio versi 10.3 dengan menerapkan algoritma pembentuk Decision Tree C4.5. Dalam menentukan kelayakan penerima, aplikasi menggunakan tujuh kriteria utama: tingkat kesejahteraan, jumlah tanggungan, jenis pekerjaan, sarana sanitasi, sumber air, jenis atap, dan jenis lantai. Algoritma C4.5 pada penelitian ini dilatih menggunakan 100 data pelatihan dan diuji dengan 20 data uji, menghasilkan akurasi sebesar 79,17% dengan faktor yang paling menentukan dalam prediksi adalah jenis lantai. Penelitian ini juga memvisualisasikan pohon keputusan yang terbentuk secara utuh untuk memudahkan interpretasi hasil prediksi dan peluang peningkatan di masa depan.
IMPLEMENTASI SUPPORT VECTOR MACHINE (SVM) DENGAN QUERY EXPANSION RANKING PADA REVIEW PENGGUNAAN JAMU MADURA
Authors: Yunitarini Rika , Fitrianto Hambali , Ayu Mufarroha Fifin
Published: January 2025

Madura traditional herbal medicine is a traditional herbal medicine made from natural ingredients and is well-known for its efficacy. The popularity of Madura traditional herbal medicine is not only based on the diversity of traditional herbal medicine products and their health benefits, but also on traditional values that have been passed down from generation to generation. One of the most popular Madura traditional herbal medicine is Peluntur traditional herbal medicine. Peluntur traditional herbal medicine is a series of medicinal or herbal products specifically designed as a solution to overcome late menstruation or irregular menstruation, which is often a source of concern for mothers and young women. With the background of the increasing demand for Madura traditional herbal medicine products, a sentiment analysis was conducted on Madura traditional herbal medicine product reviews on the Shopee, Lazada, and Tokopedia applications. This study applies Support Vector Machine and Query Expansion Ranking to achieve the highest accuracy in reviewing the use of Madura traditional herbal medicine. The results obtained for the use of the Support Vector Machine algorithm have an accuracy of 93%, while for the use of the Support Vector Machine and Query Expansion Ranking algorithms at feature selection ratios of 50% and 100% the accuracy increases to 94%.Keywords: Madura traditional herbal medicine, Peluntur traditional herbal medicine, Query Expansion Ranking, Sentiment Analysis, Support Vector Machine
Plan de negocios para desarrollar el mercado de servicios de limpieza a domicilio a través de una aplicación móvil en Lima metropolitana
Authors:   , Quispe Mansilla Linda Estefania , Vargas Guerra Leonardo Daniel , Herrera Cueva Seidi , Castillo Ramos Diego Enrique , Sanchez Reynaldo Richard
Published: January 2025

Servimax es una empresa experta en ofrecer servicios de limpieza doméstica, tanto para hogares como para oficinas, que conecta a través de un aplicativo móvil de vanguardia para facilitar la programación y gestión de dichos servicios. Con un aplicativo intuitivo y fácil de usar, aseguramos que nuestros clientes puedan acceder a servicios de limpieza de alta calidad con tan solo unos clics.
La economía colaborativa es la base de la estrategia empresarial de Servimax, conectando personales de limpieza, cuidadosamente seleccionados con clientes que demandan estos servicios. Utilizamos un proceso de selección riguroso para garantizar que todos nuestros colaboradores sean confiables, competentes y respeten los mejores niveles de calidad posibles.
Debido a la escasez de tiempo de los usuarios y a la creciente demanda de comodidad, el mercado de los servicios de limpieza a domicilio se está expandiendo rápidamente. para realizar tareas domésticas y de oficina. La empresa se posiciona para capturar una parte significativa de este mercado mediante la oferta de servicios flexibles, asequibles y de alta calidad a través de un aplicativo intuitivo y fácil de usar.
Asimismo, nuestra estrategia de marketing se centra en campañas digitales dirigidas a través de redes sociales, SEO, ASO, colaboraciones con Influencers reconocidos y publicidad con paga en línea. Además, ofrecemos grandes descuentos en programas para clientes nuevos y habituales. La satisfacción del cliente es nuestra prioridad, por lo que contamos con un sistema de retroalimentación que nos permite mejorar continuamente nuestros servicios y hacer ajustes si es necesario.
Servimax, utiliza un algoritmo avanzado dentro de la aplicación para la asignación de tareas, garantizando que los requisitos del cliente y los profesionales de la limpieza disponibles coincidan de forma eficaz...
Impacto del tratamiento periodontal subgingival sobre los marcadores sistémicos de inflamación en pacientes con sindrome metabólico: un revisión sistemática de ensayos clínicos aleatorizados
Authors:   , Ramirez Rios Asshly Yolanda , Chavez Vergara Marie Ann Ottily
Published: January 2025

Objetivo: Sintetizar la evidencia sobre el efecto del manejo periodóntico subgingival combinado con antibioticoterapia en la atenuación de marcadores sistémicos de inflamación (proteína C reactiva (PCR), interleucinas, factor de necrosis tumoral alfa (FNT-α)) en sujetos con síndrome metabólico (SM) y enfermedad periodontal (EP), en cotejo con el tratamiento periodontal supragingival más placebo. Métodos: Se incorporaron experimentos clínicos aleatorios (ECA), divulgados en idioma portugues, inglés y español, que respondieron a la pregunta de investigación. Se consultaron 8 bases de datos (PubMed, EMBASE, CINAHL, LILACS, Scopus, WoS Core Collection, Dentistry & Oral Science Source, y Cochrane Central), el 20 de junio del 2023. Se utilizó la versión 2 del instrumento Cochrane para la valoración del peligro de parcialidad en ensayos aleatorios (RoB 2), y la solidez de las pruebas se examinó conforme a las normativas del sistema GRADE. Se llevó a cabo una síntesis cualitativa de la evidencia. Resultados: Se incluyeron dos ECA con 228 participantes, de edades entre 35 y 65 años. Montero et al., identificaron diferencias estadísticamente significativas en los niveles de PCR a los 3 meses (2.7 mg/L ± EE: 0.4 vs. 3.9 mg/L ± EE: 0.6; p = 0.001) y a los 6 meses después del tratamiento (2.9 mg/L ± EE: 0.4 vs. 4.0 mg/L ± EE: 0.8; p = 0.004) a favor del grupo de tratamiento. Sin embargo, López et al. no observaron diferencias significativas en ningún mes de seguimiento. Adicionalmente, un único análisis notificó cuantificaciones de interleucina 1β y TNF-α. Montero et al. registraron divergencias notables en beneficio del conjunto terapéutico exclusivamente a los 3 meses (0.9 pg/dL + EE: 0.1 frente a 2.3 pg/dL + EE: 0.5; p = 0.046) para interleucina 1β, detectando igualmente variaciones significativas favorables al contingente tratado a los 3 meses para TNF-α...
Percepción del clima laboral en pacientes con depresión tratada en el Centro Médico Naval
Authors:   , Chumpitazi Corbera Gian Luca , Beraun Pielago Silvana Isabel
Published: January 2025

El estudio presentado a continuación tiene como propósito dar una mirada la salud mental e invita a conocer cuál es la percepción de una persona que sufre depresión con respecto a su entorno laboral, abarcando en esto su trato con las personas y su desenvolvimiento con el entorno, con la finalidad de saber si perciben un clima favorable donde logre desarrollarse adecuadamente o en caso contrario, sintiéndose limitada, ignorada o estigmatizada por su condición. OBJETIVO: Identificar la relación entre la Percepción del Clima Laboral y el Nivel de Depresión en trabajadores con depresión tratada en el Centro Médico Naval. METODOLOGÍA: Se trata de un estudio analítico observacional, no probabilístico y transversal. Se evalúo a los participantes con la Escala de Depresión de Beck II y la Escala de Clima Laboral -SPC para conocer su nivel de Depresión y su Percepción del Clima Laboral, respectivamente. Los resultados se analizaron en el programa STATA donde se aplicó la Correlación de Spearman.
Sistema de control interno y liquidez de la empresa Ariisa Contratistas Generales SAC, Miraflores 2022
Authors:   , Vallejo Calderon Luis Cleber
Published: January 2025

El estudio actual titulado “Sistema de control interno y liquidez de la empresa ARIISA Contratistas Generales SAC, Miraflores 2022”, su objetivo fue establecer de qué forma se relaciona el sistema de control interno con la liquidez de la empresa ARIISA CG SAC, Miraflores 2022, del mismo modo la importancia fue comprobar cómo la poner en práctica del sistema de control interno tiene relación en asegurar liquidez de la organización. El método que se usó fue del tipo descriptivo aplicada y enfoque cuantitativo, se empleó el método de encuesta, empleando como instrumento un cuestionario, aplicado a una muestra de 30 colaboradores de ARIISA CG S.A.C, del área administrativa, contabilidad, logístico y financiero. Se concluyó confirmando el objetivo general, se ha identificado una correlación significativa (Rho = 0,026) entre el sistema de control interno y la liquidez.
Implementación de un sistema web para optimizar el proceso de cotización en la empresa KSF Representaciones EIRL, 2022
Authors:   , Llacchuarimay de la Cruz Betsy Nataly , Gutierrez Argomedo Segundo Alexander
Published: January 2025

En esta investigación buscamos demostrar si la implementación del sistema basado en la web influye en la optimización de las actividades relacionadas al proceso de cotización de la empresa KSF Representaciones EIRL durante el año 2022. Por ello, se formula el siguiente problema: ¿En qué medida la implementación de un sistema web optimiza el proceso de cotización? Así mismo, es de tipo aplicada y diseño preexperimental, ya que, se realizará la recolección y medición de datos con un solo grupo experimental en dos etapas, mediante un pre_test y post_test con enfoque cuantitativo. La población consta de todos los registros que se realizaron desde abril del 2004, año en el que la empresa comienza a laborar, hasta junio del 2022, mes en el que el sistema comienza a operar y para la muestra, se tomó por conveniencia 24 registros de cotizaciones en promedio de los días laborables del mes de mayo del 2022 para el pretest y 24 registros de cotizaciones en promedio de los días laborables del mes de junio del 2022 para el postest, recolectados mediante una ficha de observación. Los resultados respecto a la variable del proceso de cotización muestran, para la primera dimensión en el pre_test y post_test, en la comparación de la generación de cotizaciones donde se perciben diferencias en tiempo, es decir, con el sistema se tiene menores tiempos al generar cotizaciones. Para la segunda dimensión, en el pre_test y post_test respecto a la comparación del nivel de cumplimiento de cotizaciones donde se aprecian diferencias en porcentaje, es decir, con el sistema se tiene mayor porcentaje de cumplimiento de cotizaciones. Se desarrolló la prueba de U. de Mann Whitney, que resultó significativa con un Sig. < 0.05 para las dos dimensiones, de tal manera se niega la hipótesis nula y admite la alternante...
Uso de la metodología Scrumban para desarrollar una aplicación web orientada a ventas de materiales para edificaciones, Lima 2022
Authors:   , Mamani Vargas Rebeca Sarai , Ventura Cuellar Adilson Luis
Published: January 2025

La presente investigación planteó como objetivo general determinar de qué manera el uso de la metodología Scrumban incide en el desarrollo de una aplicación web orientada a ventas de materiales para edificaciones. Este estudio está fundamentado con un enfoque cuantitativo, de tipo aplicada, con un nivel explicativo y un diseño preexperimental de método hipotético deductivo. La muestra de estudio estuvo conformada por 35 personas del área de sistemas de la empresa Grid Studio, a quienes se les aplicó un instrumento de encuesta elaborado bajo la escala Likert; estableciendo como resultado estadístico mediante la prueba t-student un valor de t=-38.353 y una sig. < 0.001, demostrando así que la metodología Scrumban si incide significativamente en el desarrollo de una aplicación web orientada a ventas de materiales para edificaciones. Se concluye que, la metodología ágil permite de manera predictiva y evolutiva la mejora de los procesos iterativos y previene contingencias por la revisión continua de los incrementos desarrollados.
Comparación de resistencia a la tensión de hilos de poliglactina 910 y ácido poliglicólico sumergidos en enjuagues bucales evaluados 3 y 7 días postinmersión
Authors:   , Rodriguez Escurra Jose Francisco
Published: January 2025

Los hilos de sutura son materiales que se utilizan para unir tejidos que se han separado por un traumatismo o por una incisión. La resistencia a la tracción es la propiedad del hilo de sutura para resistir las tensiones generadas durante el proceso de cicatrización. El objetivo principal fue comparar la resistencia a la tracción del hilo de poliglactina 910 y ácido poliglicólico al ser sumergidos en Perio-aid (gluconato de clorhexidina al 0,05% y cloruro de cetilperidinio al 0.05%), Oral B (cloruro de cetilperidinio al 0,05%) Este estudio fue experimental in vitro aplicado en 180 hilos de sutura 4/0 distribuidos en ácido poliglicólico (grupo control) y poliglactina 910 (grupo experimental) sometidos a tres sustancias de inmersión Perio-aid, Oral B y saliva artificial para evaluar la resistencia a la tracción con máquina de ensayos universal en tres tiempos preinmersión, 3 y 7 días postinmersión. El análisis estadístico se realizó mediante la prueba F de Anova para muestras repetidas y Friedman. A los 3 y 7 días postinmersión de los hilos de poliglactina 910 en CHX 0,05% + CPC 0,05%, mostraron valores de resistencia a la tensión significativamente mayores que los valores iniciales (p<0,001). A los 7 días de inmersión de los hilos de poliglactina 910 en CPC 0,05%, también mostraron valores de resistencia a la tensión significativamente mayores que los valores preinmersión (p=0,002). Hubo una disminución significativa de la resistencia a la tensión de la poliglactina 910 a los 3 y 7 días postinmersión en saliva artificial en comparación a los valores iniciales (p=0,033). A los 3 y 7 días de inmersión de los hilos de ácido poliglicólico en CHX 0,05% + CPC 0,05%, mostraron valores de resistencia a la tensión significativamente menores a los valores preinmersión (p=0,002)...
Inclusión financiera y edad: un análisis de su relación para la región Puno en el año 2019
Authors:   , Balbin Balbin Betzabe , Ccoyllo Huamani Thalia
Published: January 2025

El objetivo del presente estudio es determinar si la edad, analizada por rangos, ayuda a predecir la inclusión financiera de los individuos de la región Puno. Se utilizaron datos de la Encuesta Nacional de Hogares para el año 2019. La metodología analizada corresponde a un modelo de probabilidad lineal. Los resultados indican que el rango de edad ayuda a predecir la probabilidad de estar incluido o no en el sistema financiero.
Pillar arrays as tunable interfacial barriers for microphysiological systems
Authors: Healy Kevin , Goswami Ishan , Kim Yongdeok , Neiman Gabriel , Siemons Brian , Velazquez Jazmin , Yazgan Kerem , Ng Tammy
Published: January 2025

We report on the design and fabrication of a novel circular pillar array as an interfacial barrier for microfluidic microphysiological systems (MPS). Traditional barrier interfaces, such as porous membranes and microchannel arrays, present limitations due to inconsistent pore size, complex fabrication and device assembly, and lack of tunability using a scalable design. Our pillar array overcomes these limitations by providing precise control over pore size, porosity, and hydraulic resistance through simple modifications of pillar dimensions. Serving as an interface between microfluidic compartments, it facilitates cell aggregation for tissue formation and acts as a tunable diffusion barrier that mimics diffusion in vivo. We demonstrate the utility of barrier design to engineer physiologically relevant cardiac microtissues and a heterotypic model with vasculature within the device. Its tunable properties offer significant potential for drug screening/testing and disease modeling, enabling comparisons of drug permeability and cell migration in MPS tissue with or without vasculature.
Cultural Norms and Practices of Birth Preparedness among Indigenous Maasai Women in Northern Tanzania: A Descriptive Qualitative Study
Authors: Chanimbaga Bithia A. , Oguma Erick Donard , Moshi Fabiola Vincent , Kibusi Stephen Methew
Published: January 2025

Background: Preventable maternal morbidities and mortalities due to pregnancy-related complications can arise at any stage in pregnancy, delivery, and after. Despite efforts to encourage women to give birth in healthcare facilities, improvement has remained stagnant, particularly in remote Indigenous Maasai populationsin northern Tanzania. The study aims to explore the cultural norms and birth preparedness practices among Indigenous Maasai women in Northern Tanzania.
Methods: The study employed a descriptive qualitative study design, which was conducted from 11 April 2024 to 31 May 2024, among Indigenous Maasai women. In-depth interviews were conducted with 7 newly delivered Indigenous Maasai women, and three focus group discussions with 30 Indigenous Maasai elderly women. The thematic analysis with inductive approach was used to analyze the qualitative data.
Results: The study findings identified five overarching themes and 16 sub-themes, shedding light on the prevalent adherence to cultural norms and traditional practices surrounding childbirth. The themes encompassed traditional preparation for childbirth, culturally rooted approaches to maternal well-being, ritualistic practices during pregnancy and delivery, the collaborative roles of husbands within the family, and cultural norms associated with newborn care. These themes highlight the intricate interplay between cultural traditions and maternal health practices in the study context.
Conclusion: The study's findings reveal that Indigenous Maasai women in Tanzania adhere to traditional birth practices, which include the utilization of herbal medications and dietary modifications during pregnancy, labor, and postpartum. Their husbands play a crucial role in determining the birth location and providing assistance during labor and delivery, with a preference for traditional birth assistants (TBAs). This preference for TBAs during care and delivery increases the risk of complications for both mothers and newborns. Therefore, the study's findings emphasize an urgent need for community health educational programs focused on creating awareness of the effects of traditional practices such as restriction of food intake during pregnancy and inadequate use of skilled birth attendants among the study population to enhance maternal well-being.
Exploring a multi-omics study of micronutrients and colon cancer risk
Authors: Wu Weiqiang , Gao Feng , Gao ZhouYu , Gao Hua , Min Haoyun , Wang Ximing , Chen Jianliang , Xu Ming , Zou Min , Gui Mingbin , Wang Yanan , Lv Yang , Chang Dongmin
Published: January 2025

Background
Colorectal cancer (CRC) ranks as the third most commonly diagnosed cancer and the second leading cause of cancer-related deaths worldwide. Approximately 95% of its histologic subtypes are colon adenocarcinoma (COAD). To date, numerous studies have investigated the potential impact of circulating microelements on COAD. However, the causal association between mirculating microelements and COAD remains unclear. Therefore, our study implemented two-sample Mendelian randomization (MR) analyses to explore the causal effect.
Methods
The two-sample MR analysis, involving five methods, was designed to assess the relevance of the above genetic variants. Serval sensitivity analysis were performed for strength credibility for MR results.
Results
The current research revealed a negative association between increased selenium levels and COAD risk, while circulating zinc levels exhibited a positive association with COAD risk. Sensitivity analyses indicated no heterogeneity or polymorphism among instrumental variables.
Conclusion
Current research suggests genetic evidence of causal effects of circulating microelement on COAD, and provide valuable insights into strategies for COAD prevention and treatment.
Ischemic Heart Disease Mortality and Metabolic Risk Factors: A Global Analysis of Gender Disparities and Regional Variations (1980–2021)
Authors: Li Huili , Xiao Fei , Chen Jiaying , Wang Jiarui , Chen Yuanlu , Li Zhenyu , Lin Peirong , Wang Sheng
Published: January 2025

The mortality rate and the number of deaths from ischemic heart disease (IHD) in developing regions have surpassed those in developed regions. Since 1980, the global number of IHD deaths, disability-adjusted life years (DALY), years of life lost (YLL), and years lived with disability (YLD) have significantly increased, particularly in regions with medium and high Social Development Index (SDI). Although the overall mortality rate has declined, developing countries, especially those in the medium SDI and low-medium SDI regions, are facing a greater burden of death. In the 1990s, while the number of IHD deaths increased, the socio-economic development level (SDI) also improved. However, over the past 30 years, the number of deaths in medium SDI regions, especially in China and Central Asia, has risen sharply, with these regions experiencing a faster increase in mortality rates. In contrast, the number of deaths in high SDI regions has steadily declined. The IHD mortality rate among men is generally higher than that of women, and the gender gap may continue to widen. Globally, the main risk factors for IHD deaths include high systolic blood pressure, high low-density lipoprotein (LDL), smoking, and high blood sugar. With improvements in health management in developed regions, deaths caused by metabolic risk factors have significantly declined. However, risk factors in developing countries, particularly in low-income and middle-income regions, remain significant. Air pollution, smoking, and other factors continue to be major health threats.
Heavy metals and prostate cancer: a new study with new findings
Authors: Coradduzza Donatella , Congiargiu Antonella , Sanna Andrea , Lorenzo Biagio , Marra Sonia , Cossu Maurizio , Tedde Alessandro , Miglio Maria Rosaria , Zinellu Angelo , Mangoni Arduino A. , Cogoni Alessio Aligio , Madonia Massimo , Carru Ciriaco , Medici Serenella
Published: January 2025

Heavy metals influence the development of several health conditions, including inflammation and cancer. This study investigates the relationship between heavy metal concentrations in plasma and urine, and the presence of benign prostatic hyperplasia (BPH), precancerous lesions (PL), and prostate cancer (PC). The influence of age, total PSA levels, hemoglobin concentrations, and the monocyte-to-lymphocyte ratio (MLR) is also analyzed across the three groups: BPH, PL, and PC. Our findings reveal significant differences in vanadium and antimony concentrations in plasma, suggesting a potential role in prostate disease pathophysiology. Notably, lower plasma antimony concentrations are associated with an increased risk of PC, while plasma vanadium concentrations are significantly higher in the PL group. Regression analysis further supports the association between heavy metal concentrations and the risk of PL and PC, highlighting the potential of vanadium and copper as biomarkers or therapeutic targets for prostate health. The study also explores the impact of lead exposure on prostate cancer risk, revealing a significant association between urine lead concentration and PC. These findings underscore the complex interaction between heavy metal concentrations and prostate disease risk, emphasizing the need for further research to elucidate underlying mechanisms and explore therapeutic interventions.
Effort-reward-imbalance, burnout, and physical pain mediate the relationship between overcommitment and depression in German Emergency Medical Technicians
Authors: Manns Laura , Vögele Claus , Stammet Pascal , Schulz André
Published: January 2025

Background: Overcommitment (OC) is highly prevalent in health care employees, and may predict depression symptoms. The literature suggests that the relationship between OC and depression is mediated by Effort-Reward-Imbalance (ERI), burnout and physical pain. This study tested a two-step mediation effect between OC and depression by ERI in a first, and burnout and physical pain in a second step using a cohort of German Emergency Medical Technicians (EMTs).
Methods: A cross-sectional study was carried out on a volunteer sample of 303 EMTs in Germany. OC and ERI were assessed using the ERI questionnaire, burnout with the Maslach Burnout Inventory, physical pain with the Short Form 36, and depression with the BDI-II. The relationship between these variables was tested using a mediation analysis.
Results: We found a partial mediation effect between OC and depression via ERI, burnout (emotional exhaustion, personal accomplishment) and physical pain. The mediation effect of emotional exhaustion is significantly higher than those of depersonalization and physical pain.
Conclusions: The partial mediation effect suggests the validity of our model assumptions, but also indicates direct relationships between variables (i.e. OC, ERI and depression). The identification of emotional exhaustion as key mediator implies that prevention and intervention approaches in EMTs should be based on this indicator.
Theoretical approaches to energy and charge transfer in functional molecular materials: vibronic coupling models and quantum dynamical simulations
Authors:   , Popp jatscheslaw
Published: January 2025

The publication-based dissertation elaborates on the theoretical modelling of ultrafast processes of charge separation and migration as well as investigations of vibronic coupling and temperature effects on these processes in typical representatives of organic semiconductor materials. The systems considered were an aggregate of poly(3-hexylthiophene-2,5-diyl) (P3HT) molecules stacked along the molecular normal direction, a donor-acceptor interface of a mixture of P3HT and phenyl-C61-butyric acid methyl ester (PCBM), and a highly ordered aggregate of perylenediimide molecules linked to fluorene-thiophene donor molecules by benzothiadiazole units. The parametrisation is mainly based on electronic structure calculations (density functional theory and time-dependent density functional theory) while for quantum dynamical simulations the multiconfigurational time-dependent Hartree method (within the MCTDH program package) has been applied. The thesis is divided into four parts: In part I, fundamental theoretical concepts for the interpretation of the photophysical properties and processes relevant for charge separation in organic semiconductor materials on the one hand, and for the modelling, simulation and analysis of these processes on the other hand, are examined. In particular, methods used or further developed in the underlying publications are summarised and analysed. Part II of the thesis summarises the main results and contains detailed information on the parameterisation of the models, the simulation setup, the results and their interpretation. The publications itself are included in part III. Finally, the appendix in part IV contains detailed explanations of the theoretical background of the methods used and the references.
Terapias Adjuvantes no Tratamento de Necrose Mandibular: Relato de Casos
Authors: Brizola Jhennyfer Ribeiro , Gaetti Jardim Ellen Cristina , Pelissaro Gustavo Silva
Published: January 2025

Introdução: As necroses dos maxilares, seja a osteonecrose associada a medicamentos ou a osteorradionecrose, são condições patológicas que afetam, respectivamente, pacientes submetidos a terapêutica antireabsortiva ou inibidora angiogênica e a radioterapia em região de cabeça e pescoço. Em relação a osteonecrose dos maxilares associada a medicamentos, a American Association of Oral and Maxillofacial Surgeons determinou a classificação em estágios perante as características clínicas e imagiológicas, norteando o protocolo de tratamento. Contudo, a osteorradionecrose não possui estadiamento único, logo, diversas formas de classificar essa patologia foram referidas levando em consideração desde a resposta ao tratamento e estado da doença à extensão do envolvimento ósseo. Perante isso, o objetivo deste trabalho consiste em relatar dois casos clínicos, o primeiro com diagnóstico de osteonecrose mandibular em estágio II associada ao uso de denosumabe e o segundo, de osteorradionecrose mandibular grau II com evolução a grau III, no qual o tratamento não foi efetivo. Objetivo: Dessa maneira, abrangendo não só os aspectos clínicos e imaginológicos, mas também a relevância clínica das terapias adjuvantes, o comportamento das necroses mandibulares, bem como as possibilidades de tratamento definitivo das mesmas.
Experimental Study of Mechanical and Durability Characteristics of Bio-Mineralized Concrete: A Microstructure Analysis
Authors: Porselvan R. , Lakshmi T. S. , Tholkapiyan Muniyandi
Published: January 2025

Concrete primarily composed of cement is essential for construction but contributes to significant natural resource depletion and environmental concerns. To address this, substituting cement with pozzolanic materials (e.g., fly ash and micro silica) was explored to enhance sustainability while maintaining strength. However, challenges remain in optimizing the durability and self-healing capacity of concrete. This study aims to study the impact of bacterial concrete using Bacillus subtilis on strength and durability properties. The main focus of bio-mineralization was to improve the mechanical performance and sustainability of building materials. Concrete specimens were subjected to curing for 7, 14, and 28 days. As a result, compressive strength, flexural strength, split tensile strength, and durability parameters (i.e., water permeability and chloride penetration) were evaluated. Microstructural analysis through energy dispersion spectra and field-emitting scanning electron microscopy provided insights into the calcite precipitation mechanism within the concrete pores, aiding in densification and strength enhancement. The results demonstrated that bacterial infusion significantly improved strength at all cell concentrations compared to control specimens. Moreover, the bacterial concrete exhibited enhanced self-healing properties, as observed through reduced permeability and chloride penetration. This study highlights the potential of bacterial concrete to enhance structural performance and environmental sustainability, offering a viable solution for both improving durability and reducing the carbon footprint of concrete construction.
Geometric Modeling of Disc Furrow Profile
Authors: Yablonskyi Petro , Rogovskii Ivan , Virchenko Gennadii , Borek Kinga , Volokha Mykola , Golova Olga
Published: January 2025

The provision of sufficient quantities of food products for the population of our planet is currently an urgent global problem. One of the main approaches to successfully solving these critical issues is to improve agriculture and its technical tools, particularly tillage discs. The latter’s popularity is due to modern progressive trends in minimal tillage. Compared to plows, discs significantly reduce energy costs, contribute to soil moisture preservation, and improve anti-erosion factors. In this regard, integrated CAD/CAM/CAE/PLM systems are productive tools for practically implementing the described tasks. However, their effective functioning is impossible without developing appropriate mathematical models. This scientific publication is devoted to solving such a problem by creating an analytical geometric apparatus for forming furrow profiles depending on available diameters and installation angles of tillage discs. Simultaneously, the current trends in the construction of agricultural machinery regarding the placement of disc working bodies on individual risers with the regulation of required angles of attack and deviations from vertical were considered. The developed mathematical calculations were illustrated by corresponding graphic images of furrow profiles for specific values of indicated quantities. This research also outlines promising directions for further research on the topic under consideration. Overall, the article aims to solve the problems using the integrated processing of structural and functional parameters and characteristics for agricultural discs.
Non-invertible symmetries in finite-group gauge theory
Authors: Córdova Clay , Bastos Costa Davi , Hsin Po-Shen
Published: January 2025

We investigate the invertible and non-invertible symmetries of topological finite-group gauge theories in general spacetime dimensions, where the gauge group can be abelian or non-abelian. We focus in particular on the 0-form symmetry. The gapped domain walls that generate these symmetries are specified by boundary conditions for the gauge fields on either side of the wall. We investigate the fusion rules of these symmetries and their action on other topological defects including the Wilson lines, magnetic fluxes, and gapped boundaries. We illustrate these constructions with various novel examples, including non-invertible electric-magnetic duality symmetry in 3+1d \mathbb{Z}_2ℤ2 gauge theory, and non-invertible analogs of electric-magnetic duality symmetry in non-abelian finite-group gauge theories. In particular, we discover topological domain walls that obey Fibonacci fusion rules in 2+1d gauge theory with dihedral gauge group of order 8. We also generalize the Cheshire string defect to analogous defects of general codimensions and gauge groups and show that they form a closed fusion algebra.