bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure 4 from Loss of TGF-β Adaptor β2SP Activates Notch Signaling and SOX9 Expression in Esophageal Adenocarcinoma
Authors: Song Shumei , Maru Dipen M. , Ajani Jaffer A. , Chan Chia-Hsin , Honjo Soichiro , Lin Hui-Kuan , Correa Arlene , Hofstetter Wayne L. , Davila Marta , Stroehlein John , Mishra Lopa
Published: April 2023

PDF file - 6199K, Increased expression of stem cell markers in shβ2SP EA cells, while shSOX9 and Notch inhibitor GSI rescue the phenotype of shβ2SP. Indirect immunofluorescence was performed on SKGT-4 cells with shControl, shb2SP, double shβ2SP and shSOX9 and sh2SP treated with GSI 5M using anti-Oct3/4 or anti-Lgr5 antibodies and followed by DAPI counterstaining (blue). The merge of Oct3/4 or Lgr5 (red) with DAPI (blue) is also shown.
Supplementary Methods, Figures 1 - 2, Tables 1 - 3 from Phase I Trial of Recombinant Modified Vaccinia Ankara Encoding Epstein–Barr Viral Tumor Antigens in Nasopharyngeal Carcinoma Patients
Authors: Hui Edwin P. , Taylor Graham S. , Jia Hui , Ma Brigette B.Y. , Chan Stephen L. , Ho Rosalie , Wong Wai-Lap , Wilson Steven , Johnson Benjamin F. , Edwards Ceri , Stocken Deborah D. , Rickinson Alan B. , Steven Neil M. , Chan Anthony T.C.
Published: April 2023

PDF file - 269K, Additional detail of methodology, adverse events, epitope peptides and epitope-specific T cell responses. Also includes all results obtained using ELIspot assays with overlapping peptides and analysis of regulatory T cells in patients.
Supplementary Figures 1-7 from CCR2 Deficiency Prevents Neuronal Dysfunction and Cognitive Impairments Induced by Cranial Irradiation
Authors: Belarbi Karim , Jopson Timothy , Arellano Carla , Fike John R. , Rosi Susanna
Published: April 2023

PDF file - 3693K,Supplemental Figure S1. TAp63 isoforms induce BMP signaling;Supplemental Figure S2. ΔNp63α induces Id2 mRNA via induction of BMP signaling;Supplemental Figure S3. Schematic representation of BMP signaling status in 60 human breast cancer samples;Supplemental Figure S4. Stained negative controls for IHC/IF assays;Supplementary Figure S5. LDN193189 has anti-stem-like effects;Supplementary Figure S6. Hematoxylin and Eosin staining reveals similar tumor morphology in vehicle and LDN193189 treated groups;Supplementary Figure S7. LDN193189 treatment decreases tumor initiating capacity and increases tumor latency in limiting dilution assays.
Supplementary Figure 1 from Acute and Fractionated Irradiation Differentially Modulate Glioma Stem Cell Division Kinetics
Authors: Gao Xuefeng , McDonald J. Tyson , Hlatky Lynn , Enderling Heiko
Published: April 2023

PDF file - 122K, GSC fraction as function of symmetric division rate ps (means � s.d., n=5). Shaded area shows the original fraction of CD133+ cells in U87-MG cells estimated by Kim et al. (22).
Supplementary Figures 1 - 2 from Targeted Cancer Therapy with a 2-Deoxyglucose–Based Adriamycin Complex
Authors: Cao Jie , Cui Sisi , Li Siwen , Du Changli , Tian Junmei , Wan Shunan , Qian Zhiyu , Gu Yueqing , Chen Wei R. , Wang Guangji
Published: April 2023

PDF file - 206K, Supporting information includes fluorescence images of Bel-7402, MDA-MB-231 and MCF-7 cells after incubation with 2DG-SUC-ADM or free ADM at different time points, and dynamics and tumor-targeting ability of 2DG-ICG-Der-01 in nude mice
Supplementary Methods from Silencing of the miR-17∼92 Cluster Family Inhibits Medulloblastoma Progression
Authors: Murphy Brian L. , Obad Susanna , Bihannic Laure , Ayrault Olivier , Zindy Frederique , Kauppinen Sakari , Roussel Martine F.
Published: April 2023

PDF file - 62K, Confocal microscopy was performed using a confocal/multiphoton microscope.
Supplementary Figures 1 - 6 from Silencing of the miR-17∼92 Cluster Family Inhibits Medulloblastoma Progression
Authors: Murphy Brian L. , Obad Susanna , Bihannic Laure , Ayrault Olivier , Zindy Frederique , Kauppinen Sakari , Roussel Martine F.
Published: April 2023

PDF file - 776K, Mouse SHH medulloblastomas do not show amplification of the miR-17~92 cluster (S1); 8-mer LNA-antimiRs inhibit miR-17 and miR-19a (S2); In vitro treatment with 8-mer LNA-antimiRs of MB cells from independently derived spontaneous MBs in Ptch1+/-;Cdkn2c-/- mice inhibits cell proliferation (S3); MiR-17~92 does not target Smad5 or Smad4 (S4); MiR levels of transplantable and non-transplantable Ptch1+/-;Cdkn2c-/- and Ptch1+/-;Trp53-/- flank tumors (S5); FAM-labeled tiny LNAs are present in tissues 14 days after MB cell pre-treatment and transplantation (S6).
Supplementary Figure 4 from STC1 Expression By Cancer-Associated Fibroblasts Drives Metastasis of Colorectal Cancer
Authors: Peña Cristina , Céspedes María Virtudes , Lindh Maja Bradic , Kiflemariam Sara , Mezheyeuski Artur , Edqvist Per-Henrik , Hägglöf Christina , Birgisson Helgi , Bojmar Linda , Jirström Karin , Sandström Per , Olsson Eleonor , Veerla Srinivas , Gallardo Alberto , Sjöblom Tobias , Chang Andy C.-M. , Reddel Roger R. , Mangues Ramón , Augsten Martin , Östman Arne
Published: April 2023

PDF file - 8870K, Histopathological analysis of primary tumors.
Supplementary Figure Legend from Silencing of the miR-17∼92 Cluster Family Inhibits Medulloblastoma Progression
Authors: Murphy Brian L. , Obad Susanna , Bihannic Laure , Ayrault Olivier , Zindy Frederique , Kauppinen Sakari , Roussel Martine F.
Published: April 2023

PDF file - 109K
Supplementary Figures 1 - 2 from Thrombin Drives Tumorigenesis in Colitis-Associated Colon Cancer
Authors: Turpin Brian , Miller Whitney , Rosenfeldt Leah , Kombrinck Keith , Flick Matthew J. , Steinbrecher Kris A. , Harmel-Laws Eleana , Mullins Eric S. , Shaw Maureen , Witte David P. , Revenko Alexey , Monia Brett , Palumbo Joseph S.
Published: April 2023

PDF file - 1869KB, Modest ASO-mediated decrease in circulating prothrombin does not significantly affect mucosal injury, inflammatory cell accumulation or local inflammatory cytokine production following DSS challenge (S1). Resolution of inflammation following DSS withdrawal is not significantly affected by a modest ASO-mediated decrease in circulating prothrombin (S2).
Supplementary Figure 6 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: April 2023

PDF file - 106K, The expression of chemokine receptors by BM-derived macrophages
Supplementary Table 1 from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: April 2023

XLSX file - 170K, Supplementary Table 1: Results of the first siRNA screen aimed at identifying new EMT regulators among protein kinases Supplementary Table 2: Selected pro-MET genes from the first siRNA screen Supplementary Table 3: Selected pro-EMT genes from the first siRNA screen Supplementary Table 4: Selected pro-MET genes challenged with 2 additional siRNAs Supplementary Table 5: Selected pro-EMT genes challenged with 2 additional siRNAs
Supplementary Figure 3 from Genetic and Pharmacologic Inhibition of mTORC1 Promotes EMT by a TGF-β–Independent Mechanism
Authors: Mikaelian Ivan , Malek Mouhannad , Gadet Rudy , Viallet Jean , Garcia Amandine , Girard-Gagnepain Anaïs , Hesling Cédric , Gillet Germain , Gonzalo Philippe , Rimokh Ruth , Billaud Marc
Published: April 2023

PDF file - 6734K, Supplementary Figure 3: Consequences of mTOR inhibition on epithelial integrity.
Supplementary Figure 4 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: April 2023

PDF file - 614K, Cycloheximide chase assay results indicate that the NRF2-E82G and the NRF2-V36del are more stable than the wild-type NRF2 (NRF2-WT)
Supplementary Methods from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: April 2023

PDF file - 99K, Materials and methods of CytoCy5S synthesis, purification, spectral and structural characterization in addition to NTR/CytoCy5S enzymatic reaction conditions and western blots.
Supplementary Figure 5 from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: April 2023

PDF file - 718K, In vitro viability of NB4 and MDA-MB-231 cells � NTR � MTZ.
Supplementary Figure Legend from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: April 2023

PDF file - 77K
Supplementary Figure 7 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: April 2023

PDF file - 67K, Control or PIP4K2B knockdown MCF10A cells were labelled with 32P-orthophosphate for two hours after which lipids were extracted, deacetylated and the lipid head groups were separated by HPLC. Radioactivity was quantified using an online detector and the data are presented as counts in each head group divided by the total counts + the SD. B. Lipids were extracted from control or PIP4K2B knockdown MCF10A cells and the abundance of PtdIns5P was measured. The data are presented as the pmoles of PtdIns5P/nmol of total lipid phosphate +the SD.
Supplementary Figure 1 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: April 2023

PDF file - 65K, A. Lysates from control (pLKO1) or PIP4k2B (shPIP4k2B) knockdown MCF10A cells were immunoblotted using the PIP4K2BP6 antibody. B. The PIP4K2BP6 antibody was immunodepleted by passing it through a column to which the P6 antigenic peptide was coupled. The antibody before or after, as indicated, was used to probe western blots of increasing levels of PIP4K2B .
Supplementary Tables 1-3 from Chromosome Instability Modulated by BMI1–AURKA Signaling Drives Progression in Head and Neck Cancer
Authors: Chou Chun-Hung , Yang Neng-Kai , Liu Ting-Yun , Tai Shyh-Kuan , Hsu Dennis Shin-Shian , Chen Ya-Wei , Chen Yann-Jang , Chang Cheng-Chi , Tzeng Cheng-Hwai , Yang Muh-Hwa
Published: April 2023

PDF file - 95KB, Sequence of the oligonucleotides for shRNA construct-making, reverse transcription, real-time PCR, and ChIP assay (S1); List of proteins tested by antibodies and characteristics of the corresponding antibodies (S2); Expression profile of microRNAs in FaDu-Bmi1 versus FaDu-cDNA3 (S3)
Supplementary Methods, Figure Legends, Table 1 from Activation of SOX2 Expression by BRD4-NUT Oncogenic Fusion Drives Neoplastic Transformation in NUT Midline Carcinoma
Authors: Wang Ranran , Liu Wei , Helfer Christine M. , Bradner James E. , Hornick Jason L. , Janicki Susan M. , French Christopher A. , You Jianxin
Published: April 2023

PDF file - 122KB, Supplementary Table S1. Real-time PCR primers used in this study.
Supplementary Figure 1 from Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells
Authors: Kozono Shingo , Ohuchida Kenoki , Eguchi Daiki , Ikenaga Naoki , Fujiwara Kenji , Cui Lin , Mizumoto Kazuhiro , Tanaka Masao
Published: April 2023

PDF file - 141K, Supplementary Figure 1: A and B. Expression analysis of α-SMA, glial fibrillary acidic protein (GFAP), and cytokeratin 19 in human PSCs isolated from pancreatic ductal adenocarcinoma.
Supplementary Figures 1 - 3 from USP22 Regulates Oncogenic Signaling Pathways to Drive Lethal Cancer Progression
Authors: Schrecengost Randy S. , Dean Jeffry L. , Goodwin Jonathan F. , Schiewer Matthew J. , Urban Mark W. , Stanek Timothy J. , Sussman Robyn T. , Hicks Jessica L. , Birbe Ruth C. , Draganova-Tacheva Rossitza A. , Visakorpi Tapio , DeMarzo Angelo M. , McMahon Steven B. , Knudsen Karen E.
Published: April 2023

PDF file - 176K, Supplementary Figure S1: USP22 Specifically Promotes AR Recruitment to Target Loci. Supplementary Figure 2: Depletion of USP22 can be mediated by multiple sequences.Supplementary Figure S3: AR Ubiquitylation Levels are not Altered in Response to USP22 Depletion.
Supplementary Figure 4 from Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
Authors: Spassov Danislav S. , Wong Ching Hang , Wong Sunny Y. , Reiter Jeremy F. , Moasser Mark M.
Published: April 2023

PDF file - 82K, Cell aggregation vs cell growth in PyMT tumor cells
Supplementary Figures 1 - 8 from Monoclonal Antibody Targeting of the Cell Surface Molecule TM4SF5 Inhibits the Growth of Hepatocellular Carcinoma
Authors: Kwon Sanghoon , Choi Kyung-Chan , Kim Young-Eun , Ha Yang-Wha , Kim Dongbum , Park Byoung Kwon , Wu Guang , Kim Doo-Sik , Lee Younghee , Kwon Hyung-Joo
Published: April 2023

PDF file - 1470KB, Supplementary Figure S1. Purification and reactivity analysis of anti-TM4SF5 monoclonal antibody. Supplementary Figure S2. Specificity of anti-TM4SF5 monoclonal antibody. Supplementary Figure S3. Investigation of TM4SF5 expression in normal tissues. Supplementary Figure S4. Expression of TM4SF5 in HCC tissues. Supplementary Figure S5. Analysis of TM4SF5 expression in various cancer tissues. Supplementary Figure S6. Effects of the anti-TM4SF5 monoclonal antibody on E-cadherin expression. Supplementary Figure S7. Effects of the anti-TM4SF5 monoclonal antibody on actin organization. Supplementary Figure S8. Time-dependent biodistribution of the anti-TM4SF5 monoclonal antibody in HCC tumor tissue.
Supplementary Figure 5 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: April 2023

PDF file - 1086K, Fig. S5: Knocking out VLA-4 in mouse myelomonocytic leukemia cells or human AML leukemic cells induces drug sensitivity which is not further enhanced by AS101.
Supplementary Figure 1 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: April 2023

PDF file - 85K, Scheme of the mathematical model, describing the linear relation between input data (mRNA expression of Rev-erbalpha and Bmal1) and output data (body weight loss - BWL).
Supplementary Figure Legends from Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer
Authors: Zhou Zhuan , Liu Fangfang , Zhang Zhi-Song , Shu Feifei , Zheng Yangyang , Fu Li , Li Lu-Yuan
Published: April 2023

PDF file - 148KB
Supplementary Tables 1 - 2 from Phenotypic Profiling of DPYD Variations Relevant to 5-Fluorouracil Sensitivity Using Real-time Cellular Analysis and In Vitro Measurement of Enzyme Activity
Authors: Offer Steven M. , Wegner Natalie J. , Fossum Croix , Wang Kangsheng , Diasio Robert B.
Published: April 2023

PDF file - 74K, Supplementary Tables: 1. Primers used for site directed mutagenesis of DPYD expression plasmids. 2. Primers used for sequencing of DPYD expression plasmids.
Supplementary Figure 2 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering
Authors: Romero Ana I. , Chaput Nathalie , Poirier-Colame Vichnou , Rusakiewicz Sylvie , Jacquelot Nicolas , Chaba Kariman , Mortier Erwan , Jacques Yannick , Caillat-Zucman Sophie , Flament Caroline , Caignard Anne , Messaoudene Meriem , Aupérin Anne , Vielh Philippe , Dessen Philippe , Porta Camillo , Mateus Christine , Ayyoub Maha , Valmori Danila , Eggermont Alexander , Robert Caroline , Zitvogel Laurence
Published: April 2023

PDF file - 84K, The combination therapy induced a profound lymphopenia.
Supplementary Figure 1 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering
Authors: Romero Ana I. , Chaput Nathalie , Poirier-Colame Vichnou , Rusakiewicz Sylvie , Jacquelot Nicolas , Chaba Kariman , Mortier Erwan , Jacques Yannick , Caillat-Zucman Sophie , Flament Caroline , Caignard Anne , Messaoudene Meriem , Aupérin Anne , Vielh Philippe , Dessen Philippe , Porta Camillo , Mateus Christine , Ayyoub Maha , Valmori Danila , Eggermont Alexander , Robert Caroline , Zitvogel Laurence
Published: April 2023

PDF file - 25K, Schedule of the sorafenib and temozolomide combination regimen.
Supplementary Figure Legends from A Meta-analysis of Lung Cancer Gene Expression Identifies PTK7 as a Survival Gene in Lung Adenocarcinoma
Authors: Chen Ron , Khatri Purvesh , Mazur Pawel K. , Polin Melanie , Zheng Yanyan , Vaka Dedeepya , Hoang Chuong D. , Shrager Joseph , Xu Yue , Vicent Silvestre , Butte Atul J. , Sweet-Cordero E. Alejandro
Published: April 2023

PDF file - 84KB
Supplementary Table 2 from Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression
Authors: Vallacchi Viviana , Vergani Elisabetta , Camisaschi Chiara , Deho Paola , Cabras Antonello D. , Sensi Marialuisa , De Cecco Loris , Bassani Niccolò , Ambrogi Federico , Carbone Antonino , Crippa Federica , Vergani Barbara , Frati Paola , Arienti Flavio , Patuzzo Roberto , Villa Antonello , Biganzoli Elia , Canevari Silvana , Santinami Mario , Castelli Chiara , Rivoltini Licia , Rodolfo Monica
Published: April 2023

XLSX file - 2088K, Supplementary Table S2.Differentially expressed gene lists.
Supplementary Figure 1 from Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression
Authors: Vallacchi Viviana , Vergani Elisabetta , Camisaschi Chiara , Deho Paola , Cabras Antonello D. , Sensi Marialuisa , De Cecco Loris , Bassani Niccolò , Ambrogi Federico , Carbone Antonino , Crippa Federica , Vergani Barbara , Frati Paola , Arienti Flavio , Patuzzo Roberto , Villa Antonello , Biganzoli Elia , Canevari Silvana , Santinami Mario , Castelli Chiara , Rivoltini Licia , Rodolfo Monica
Published: April 2023

PDF file - 68K, Supplementary Figure S1.Expression levels of melanoma genes in the SNB samples, as indicated by the array data. The genes and SNB groups are indicated, and the intensity values (minimum to maximum) and the median are shown. The values for the PN or PP samples in comparison with the N samples are indicated (*, p<0.05) and shown in colors. S100B, S100 calcium-binding protein beta; MLANA, Mart-1; SILV, HMB-45/melanocyte protein Pmel17; MITF, microphthalmia-associated transcription factor; TYR, tyrosinase; ASIP, agouti signaling protein; DCT, dopachrome tautomerase; GPR143, G protein-coupled receptor 143/OA1; MC1R, melanocortin-1 receptor; MIA, melanoma inhibitory activity protein; PRAME, preferentially expressed antigen in melanoma; RAB27A, ras-related protein Rab-27; SLC24A5, solute carrier family 24 member 5; SLC24A2, solute carrier family 45 member 2/MTAP; TRPM1, melastatin 1; TYRP1, tyrosinase-related protein 1.
Supplementary Figure 1 from Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK
Authors: Doma Eszter , Rupp Christian , Varga Andrea , Kern Florian , Riegler Bettina , Baccarini Manuela
Published: April 2023

PDF file - 197K, Effect of GDC‐0879 on wild‐type mice.
Supplementary Figure 2 from DNA Damage–Specific Control of Cell Death by Cryptochrome in p53-Mutant Ras–Transformed Cells
Authors: Lee Jin Hyup , Gaddameedhi Shobhan , Ozturk Nuri , Ye Rui , Sancar Aziz
Published: April 2023

PDF file - 150K, Induction of p73 transcription by UV in p53-/- and p53-/-Cry1/2-/- cells
Supplementary Figure 8 from Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer
Authors: LeBeau Aaron M. , Duriseti Sai , Murphy Stephanie T. , Pepin Francois , Hann Byron , Gray Joe W. , VanBrocklin Henry F. , Craik Charles S.
Published: April 2023

PDF file - 62K, FDG avid lesion not detected by 111In-2G10
Supplemental figure 3 from MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation
Authors: Rho Jin Kyung , Choi Yun Jung , Kim Seon Ye , Kim Tae Won , Choi Eun Kyung , Yoon Seon-Joo , Park Bu Man , Park Eunhye , Bae Jong Hwan , Choi Chang-Min , Lee Jae Cheol
Published: April 2023

Figure - Fig S3. Effect of afatinib on H820
Supplemental figure 1 from MET and AXL Inhibitor NPS-1034 Exerts Efficacy against Lung Cancer Cells Resistant to EGFR Kinase Inhibitors Because of MET or AXL Activation
Authors: Rho Jin Kyung , Choi Yun Jung , Kim Seon Ye , Kim Tae Won , Choi Eun Kyung , Yoon Seon-Joo , Park Bu Man , Park Eunhye , Bae Jong Hwan , Choi Chang-Min , Lee Jae Cheol
Published: April 2023

Fig S1. Inhbitory effect of NPS-1034 on kinases
Supplementary Methods from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: April 2023

PDF file - 88K
Supplementary Figure 5 from Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer
Authors: Alizadeh Darya , Trad Malika , Hanke Neale T. , Larmonier Claire B. , Janikashvili Nona , Bonnotte Bernard , Katsanis Emmanuel , Larmonier Nicolas
Published: April 2023

PDF file - 58K, Doxorubicin eliminates MDSC in mice bearing EMT6 breast cancer or EL4 thymoma.
Supplementary Figure 3 from Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer
Authors: Alizadeh Darya , Trad Malika , Hanke Neale T. , Larmonier Claire B. , Janikashvili Nona , Bonnotte Bernard , Katsanis Emmanuel , Larmonier Nicolas
Published: April 2023

PDF file - 124K, Doxorubicin administration increases the effector to suppressor ratios in 4T1 tumor bearing mice but does not alter Treg numbers.
Supplementary Figure 5 from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: April 2023

PDF file - 101K, Only in vitro stimulated GM-CSF-derived BMDCs produce IL-23.
Supplementary Figure 3 from RSF1 Is a Positive Regulator of NF-κB–Induced Gene Expression Required for Ovarian Cancer Chemoresistance
Authors: Yang Yeong-In , Ahn Ji-Hye , Lee Kyung-Tae , Shih Ie-Ming , Choi Jung-Hye
Published: April 2023

PDF file - 56KB, Expression of hSNF2H and CBP in SKOV3, OVCAR3, SKOV3TR, and OVCAR3TR cells.
Supplementary Figure 2 from RSF1 Is a Positive Regulator of NF-κB–Induced Gene Expression Required for Ovarian Cancer Chemoresistance
Authors: Yang Yeong-In , Ahn Ji-Hye , Lee Kyung-Tae , Shih Ie-Ming , Choi Jung-Hye
Published: April 2023

PDF file - 54KB, Effect of RSF1 induction on mRNA expression of NFkappaB p65 subunit.
Supplementary Methods, Figures 1 - 7, Tables 1 - 3 from LEO1 Is Regulated by PRL-3 and Mediates Its Oncogenic Properties in Acute Myelogenous Leukemia
Authors: Chong Phyllis S.Y. , Zhou Jianbiao , Cheong Lip-Lee , Liu Shaw-Cheng , Qian Jingru , Guo Tiannan , Sze Siu Kwan , Zeng Qi , Chng Wee Joo
Published: April 2023

Supplementary Materials and Methods. Table S1. List of upregulated and downregulated proteins identified by MS. Table S2. Primer sequences for real-time quantitative PCR. Table S3. Primer sequences used in ChIP assay on Leo1 promoter region. Figure S1. Schematic overview of SILAC approach and data analysis. Figure S2. PRL-3 upregulates Leo1 in a dose-dependent manner. Figure S3. Expression of PRL-3 and Leo1 in normal human peripheral blood sample. Figure S4. Knockdown of PRL-3 affects global histone marks. Figure S5. Leo1 promoter is not modulated by H3K27me3. Figure S6. Leo1 promoter region is regulated by JMJD2C. Figure S7. Effects of Paf1, Ctr9 or Leo1 knockdown in TF1-hPRL3 cells.
Supplementary Figure 2 from Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1–PALB2–BRCA2 Complex
Authors: Al Abo Muthana , Dejsuphong Donniphat , Hirota Kouji , Yonetani Yasukazu , Yamazoe Mitsuyoshi , Kurumizaka Hitoshi , Takeda Shunichi
Published: April 2023

PDF file - 367K, Generation of mutant BRCA2 allelic genes: BRCA2deltaN, BRCA2deltaN+BRC3tr, BRCA2deltaDBD and BRCA2deltaN+deltaDBD.
Supplementary Figure 6 from A Rare Polymorphic Variant of NBS1 Reduces DNA Repair Activity and Elevates Chromosomal Instability
Authors: Yamamoto Yuki , Miyamoto Mamiko , Tatsuda Daisuke , Kubo Michiaki , Nakagama Hitoshi , Nakamura Yusuke , Satoh Hitoshi , Matsuda Koichi , Watanabe Toshiki , Ohta Tsutomu
Published: April 2023

PDF file - 1980KB, The NBS1-I171V polymorphic variant reduced focus counts of MRE11 and phospho RPA32.
Supplementary Table 1 from Mechanisms of Resistance to Intermittent Androgen Deprivation in Patients with Prostate Cancer Identified by a Novel Computational Method
Authors: Morken Jason D. , Packer Aaron , Everett Rebecca A. , Nagy John D. , Kuang Yang
Published: April 2023

PDF file - 44KB, Table S1. MSE values.
Supplementary Figures 1-9 from ERK1/2 Blockade Prevents Epithelial–Mesenchymal Transition in Lung Cancer Cells and Promotes Their Sensitivity to EGFR Inhibition
Authors: Buonato Janine M. , Lazzara Matthew J.
Published: April 2023

Supplementary Materials PDF file 1972K, Figure S1. Titration of U0126 reveals inhibitor concentrations needed to maintain ERK phosphorylation suppression at early and late times after inhibitor addition to cells. Figure S2. MEK inhibition by CI-1040 prevents TGF{beta}-induced EMT in H1666 cells. Figure S3. MEK inhibition by CI-1040 promotes epithelial characteristics in H1666 cells. Figure S4. Chronic MEK inhibition sensitizes H1666 cells to EGFR inhibition. Figure S5. MEK inhibition augments cellular response to EGFR inhibition in additional NSCLC and breast cancer cell lines. Figure S6. Changes in epithelial/mesenchymal markers and markers of stem cells brought about by MEK inhibition are reversible upon removal of MEK inhibitors. Figure S7. MEK inhibition by CI-1040 promotes epithelial characteristics in an NSCLC cell line with an EGFR-activating mutation. Figure S8. MEK inhibition sensitizes cells with acquired resistance to EGFR inhibitors as cells become more epithelial. Figure S9. PC9 cells with acquired resistance to EGFR inhibitors become more epithelial with inhibition of dynamin.
Supplementary Methods, Figure Legend from Blocking Lactate Export by Inhibiting the Myc Target MCT1 Disables Glycolysis and Glutathione Synthesis
Authors: Doherty Joanne R. , Yang Chunying , Scott Kristen E.N. , Cameron Michael D. , Fallahi Mohammad , Li Weimin , Hall Mark A. , Amelio Antonio L. , Mishra Jitendra K. , Li Fangzheng , Tortosa Mariola , Genau Heide Marika , Rounbehler Robert J. , Lu Yunqi , Dang Chi V. , Kumar K. Ganesh , Butler Andrew A. , Bannister Thomas D. , Hooper Andrea T. , Unsal-Kacmaz Keziban , Roush William R. , Cleveland John L.
Published: April 2023

PDF file - 358K
Supplementary Figure 6 from PP2A-B55β Antagonizes Cyclin E1 Proteolysis and Promotes Its Dysregulation in Cancer
Authors: Tan YingMeei , Sun Dahui , Jiang Weijian , Klotz-Noack Kathleen , Vashisht Ajay A. , Wohlschlegel James , Widschwendter Martin , Spruck Charles
Published: April 2023

PDF file - 73KB, B55beta expression knockdown inhibits the growth and decreases cyclin E1 protein levels in colorectal cancer cell lines containing hypermethylated PP2R2B alleles (3). A, Growth of HT29 and HCT116 colorectal carcinoma cells transfected with control or B55beta siRNA measured 96 hrs post-transfection. Experiments were performed in triplicate. B, Western blot of cyclin E1 in HT29 cells 48 hrs post-transfection. Ku86 is shown as loading control.
Supplementary Table 1 from Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions
Authors: Kwong Lawrence N. , Chin Lynda
Published: April 2023

XLSX file - 68KB, The shRNA pools used in the iNRAS-463 primary in vivo screen.
Supplementary Figure 5 from Chromosome 10, Frequently Lost in Human Melanoma, Encodes Multiple Tumor-Suppressive Functions
Authors: Kwong Lawrence N. , Chin Lynda
Published: April 2023

PDF file - 59KB, RAS/RAF mutations correlate with chr 10 status.
Supplementary Table 7 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells
Authors: Goc Jérémy , Germain Claire , Vo-Bourgais Thi Kim Duy , Lupo Audrey , Klein Christophe , Knockaert Samantha , de Chaisemartin Luc , Ouakrim Hanane , Becht Etienne , Alifano Marco , Validire Pierre , Remark Romain , Hammond Scott A. , Cremer Isabelle , Damotte Diane , Fridman Wolf-Herman , Sautès-Fridman Catherine , Dieu-Nosjean Marie-Caroline
Published: April 2023

PDF file - 78K, Multivariate Cox proportional hazards analysis for overall survival in NSCLC patients.
Supplementary Table 6 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells
Authors: Goc Jérémy , Germain Claire , Vo-Bourgais Thi Kim Duy , Lupo Audrey , Klein Christophe , Knockaert Samantha , de Chaisemartin Luc , Ouakrim Hanane , Becht Etienne , Alifano Marco , Validire Pierre , Remark Romain , Hammond Scott A. , Cremer Isabelle , Damotte Diane , Fridman Wolf-Herman , Sautès-Fridman Catherine , Dieu-Nosjean Marie-Caroline
Published: April 2023

PDF file - 131K, Clinical characteristic of NSCLC patients with DC-Lamp High versus DC-Lamp Low tumors.
Supplementary Figure S8 from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
Authors: Tan Peng H. , Tyrrell Helen E.J. , Gao Liquan , Xu Danmei , Quan Jianchao , Gill Dipender , Rai Lena , Ding Yunchuan , Plant Gareth , Chen Yuan , Xue John Z. , Handa Ashok I. , Greenall Michael J. , Walsh Kenneth , Xue Shao-An
Published: April 2023

Transduction of AdipoR1/R2 into murine DCs promotes antigen specific tolerance in vitro.
Supplementary Figure S1 from Adiponectin Receptor Signaling on Dendritic Cells Blunts Antitumor Immunity
Authors: Tan Peng H. , Tyrrell Helen E.J. , Gao Liquan , Xu Danmei , Quan Jianchao , Gill Dipender , Rai Lena , Ding Yunchuan , Plant Gareth , Chen Yuan , Xue John Z. , Handa Ashok I. , Greenall Michael J. , Walsh Kenneth , Xue Shao-An
Published: April 2023

Overexpression of APN receptors on patient's DCs inhibits anti-tumor immunity.
Supplementary Figure 2 from Dendritic Cells in Tumor-Associated Tertiary Lymphoid Structures Signal a Th1 Cytotoxic Immune Contexture and License the Positive Prognostic Value of Infiltrating CD8+ T Cells
Authors: Goc Jérémy , Germain Claire , Vo-Bourgais Thi Kim Duy , Lupo Audrey , Klein Christophe , Knockaert Samantha , de Chaisemartin Luc , Ouakrim Hanane , Becht Etienne , Alifano Marco , Validire Pierre , Remark Romain , Hammond Scott A. , Cremer Isabelle , Damotte Diane , Fridman Wolf-Herman , Sautès-Fridman Catherine , Dieu-Nosjean Marie-Caroline
Published: April 2023

PDF file - 113K, Determination of the optimal cut-off value for the discrimination between high and low densities of DC-Lamp, CD8S and CD8T markers.
Supplementary Figures 1 through 6 from Integrin αvβ6 Promotes an Osteolytic Program in Cancer Cells by Upregulating MMP2
Authors: Dutta Anindita , Li Jing , Lu Huimin , Akech Jacqueline , Pratap Jitesh , Wang Tao , Zerlanko Brad J. , FitzGerald Thomas J. , Jiang Zhong , Birbe Ruth , Wixted John , Violette Shelia M. , Stein Janet L. , Stein Gary S. , Lian Jane B. , Languino Lucia R.
Published: April 2023

PDF - 529K, Expression of alphavbeta6 does not affect PC3-2 integrin profile (S1); alphavbeta6 promotes osteolysis in vivo (S2); alphavbeta6 increases osteolytic lesions and osteoclast recruitment in vivo (S3); Downregulation of alphavbeta6 reduces MMP2 levels in RWPE cells (S4); Exogenous expression of alphavbeta6 and alphavbeta3 in C4-2B transfectants (S5); MMP2 is co-expressed with alphavbeta6 in human prostate cancer osteolytic metastases (S6).
Supplementary Figure 4 from microRNA-148a Is a Prognostic oncomiR That Targets MIG6 and BIM to Regulate EGFR and Apoptosis in Glioblastoma
Authors: Kim Jungeun , Zhang Ying , Skalski Michael , Hayes Josie , Kefas Benjamin , Schiff David , Purow Benjamin , Parsons Sarah , Lawler Sean , Abounader Roger
Published: April 2023

PDF file - 23K, miR-148a inhibits MIG6 and BIM mRNA expression.
Supplementary Table 6 from Fusobacterium in Colonic Flora and Molecular Features of Colorectal Carcinoma
Authors: Tahara Tomomitsu , Yamamoto Eiichiro , Suzuki Hiromu , Maruyama Reo , Chung Woonbok , Garriga Judith , Jelinek Jaroslav , Yamano Hiro-o , Sugai Tamotsu , An Byonggu , Shureiqi Imad , Toyota Minoru , Kondo Yutaka , Estécio Marcos R.H. , Issa Jean-Pierre J.
Published: April 2023

XLSX file - 45K, Mutated genes in CIMP1 with FB-high (n=2), CIMP1 with low/undetectable FB (n=6) and CIMP2/CIMP-negative with low/undetectable FB (n=and common elements in these groups.
Supplementary Table 1 from Blocking eIF5A Modification in Cervical Cancer Cells Alters the Expression of Cancer-Related Genes and Suppresses Cell Proliferation
Authors: Mémin Elisabeth , Hoque Mainul , Jain Mohit R. , Heller Debra S. , Li Hong , Cracchiolo Bernadette , Hanauske-Abel Hartmut M. , Pe'ery Tsafi , Mathews Michael B.
Published: April 2023

PDF - 74K, Table S1. Identification of drug-dependent spots.
Supplementary Figure 3 from Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer
Authors: Collazo Joanne , Zhu Beibei , Larkin Spencer , Martin Sarah K. , Pu Hong , Horbinski Craig , Koochekpour Shahriar , Kyprianou Natasha
Published: April 2023

PDF file - 40KB, Constitutively inactive form of cofilin (S3DCFL) decreases prostate cancer cell migration and ECM-adhesion. Panel A, Mutation mimicking the constitutively active form of cofilin (S3ACFL) increases prostate cancer cell migration (p<0.03). In contrast, PC-3 prostate cancer cells harboring the S3DCFL mutation (inactive CFL) exhibited a significantly reduced migration capacity compared to S3ACFL cells (p<0.006) (to levels comparable to WTCFL). Panel B, Cell adhesion to fibronectin-coated matrix was significantly reduced in PC-3 S3DCFL cells, compared to WTCFL. Statistical significance, p<0.05.
Supplementary Figure 2 from Cofilin Drives Cell-Invasive and Metastatic Responses to TGF-β in Prostate Cancer
Authors: Collazo Joanne , Zhu Beibei , Larkin Spencer , Martin Sarah K. , Pu Hong , Horbinski Craig , Koochekpour Shahriar , Kyprianou Natasha
Published: April 2023

PDF file - 41KB, TGF-β leads to cofilin dephsphorylation and activation (via regulating RhoA) in human LNCaP TβRII prostate cancer cells.
Supplementary Figure 1 from EGF Receptor Activates MET through MAPK to Enhance Non–Small Cell Lung Carcinoma Invasion and Brain Metastasis
Authors: Breindel Jerrica L. , Haskins Jonathan W. , Cowell Elizabeth P. , Zhao Minghui , Nguyen Don X. , Stern David F.
Published: April 2023

PDF file - 1350K, Ligand-dependent phosphorylation of MET and EGFR in 32D cells.
Supplementary Figure 6 from HuR Posttranscriptionally Regulates WEE1: Implications for the DNA Damage Response in Pancreatic Cancer Cells
Authors: Lal Shruti , Burkhart Richard A. , Beeharry Neil , Bhattacharjee Vikram , Londin Eric R. , Cozzitorto Joseph A. , Romeo Carmella , Jimbo Masaya , Norris Zoë A. , Yeo Charles J. , Sawicki Janet A. , Winter Jordan M. , Rigoutsos Isidore , Yen Timothy J. , Brody Jonathan R.
Published: April 2023

PDF file - 497KB, HuR regulates WEE1 expression.
Supplementary Figure 2 from VISTA Is an Immune Checkpoint Molecule for Human T Cells
Authors: Lines J. Louise , Pantazi Eirini , Mak Justin , Sempere Lorenzo F. , Wang Li , O'Connell Samuel , Ceeraz Sabrina , Suriawinata Arief A. , Yan Shaofeng , Ernstoff Marc S. , Noelle Randolph
Published: April 2023

PDF file - 122KB, human VISTA shows a hematopoietically restricted expression pattern. Quantitative RT-PCR was performed on a TissueScan human normal cDNA array using VISTA (a), and PD-L1 (b) Taqman assays. Data is pooled from two separately processed plates.
Supplementary Figure 1 from VISTA Is an Immune Checkpoint Molecule for Human T Cells
Authors: Lines J. Louise , Pantazi Eirini , Mak Justin , Sempere Lorenzo F. , Wang Li , O'Connell Samuel , Ceeraz Sabrina , Suriawinata Arief A. , Yan Shaofeng , Ernstoff Marc S. , Noelle Randolph
Published: April 2023

PDF file - 126KB, mAb anti-VISTA clones GA1 and GG8 specifically bind to human VISTA. a) human PBMCs were stained with anti-CD33 and anti-VISTA clone GA1 (red and blue) or isotype control (grey). Blocking VISTA-Ig was included in one sample to show specificity (red). Representative overlays show live, large scatter, singlet, CD33 positive events from at least two separate donors. b) K562 cells transduced with human VISTA (red) or parent K562 cells (grey) were stained with anti-VISTA clone GA1. Representative overlays show live, singlet events. c) consecutive sections of human splenic tissues were stained with anti-VISTA clone GG8 and/or Blocking VISTA-Ig. A pre-incubation step with Fc Receptor Blocking Solution (Human TruStain FcX, BioLegend) was included in some tissue samples as indicated.
Supplemental Table S3 from ATR Inhibitors VE-821 and VX-970 Sensitize Cancer Cells to Topoisomerase I Inhibitors by Disabling DNA Replication Initiation and Fork Elongation Responses
Authors: Jossé Rozenn , Martin Scott E. , Guha Rajarshi , Ormanoglu Pinar , Pfister Thomas D. , Reaper Philip M. , Barnes Christopher S. , Jones Julie , Charlton Peter , Pollard John R. , Morris Joel , Doroshow James H. , Pommier Yves
Published: April 2023

Supplemental Table S3. Summary of siRNA follow-up studies. siRNAs were evaluated in the context of a camptothecin dose response. The primary screen rank is listed for each gene along with the number of siRNAs yielding a 2-fold or greater sensitization. All genes were tested with at least 4 siRNAs from Qiagen (Q). Many genes were characterized with 3 additional siRNAs from Ambion (A). The percent of tested siRNAs yielding a 2-fold or greater sensitization is listed for each gene.
Supplementary Figure Legends from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 93KB
Supplementary Figure 7 from Increased Dietary Vitamin D Suppresses MAPK Signaling, Colitis, and Colon Cancer
Authors: Meeker Stacey , Seamons Audrey , Paik Jisun , Treuting Piper M. , Brabb Thea , Grady William M. , Maggio-Price Lillian
Published: April 2023

PDF file - 149K, AIN93Null diet does not alter expression of proinflammatory and chemotactic cytokines in proximal colon tissue 1 week post H. bilis-infection.
Supplementary Figure 6 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 66KB, Supplementary Figure S6 shows IC50 values of indicated drugs on Her2/Neu-monolayer, SKBR3, HCC1954 or JIMT1 cells.
Supplementary Figure 1 from shRNA Kinome Screen Identifies TBK1 as a Therapeutic Target for HER2+ Breast Cancer
Authors: Deng Tao , Liu Jeff C. , Chung Philip E.D. , Uehling David , Aman Ahmed , Joseph Babu , Ketela Troy , Jiang Zhe , Schachter Nathan F. , Rottapel Robert , Egan Sean E. , Al-awar Rima , Moffat Jason , Zacksenhaus Eldad
Published: April 2023

PDF file - 51KB, Supplementary Figure S1 summarizes the primary screens including number of shRNAs/kinases tested, and number of hits on Her2+ tumorspheres only, tumorsphere plus monolayer or monolayer only.
Supplementary Figure S6 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: April 2023

Ectopic expression or knockdown of LIMD2 stimulates or abrogates cell migration and anchorage-independent growth.
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: April 2023

Supplementary Methods and figure Legends
Data Supplement from BMP4 Inhibits Breast Cancer Metastasis by Blocking Myeloid-Derived Suppressor Cell Activity
Authors: Cao Yuan , Slaney Clare Y. , Bidwell Bradley N. , Parker Belinda S. , Johnstone Cameron N. , Rautela Jai , Eckhardt Bedrich L. , Anderson Robin L.
Published: April 2023

Supplementary Figure 1. BMP4 regulates G-CSF in the weakly metastatic EO771 cells.
Supplementary Figure S2 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: April 2023

Total mRNA was extracted from cancer cell lines using RNeasy Mini Kit (Qiagen).
Supplementary Figure S1 from LIMD2 Is a Small LIM-Only Protein Overexpressed in Metastatic Lesions That Regulates Cell Motility and Tumor Progression by Directly Binding to and Activating the Integrin-Linked Kinase
Authors: Peng Hongzhuang , Talebzadeh-Farrooji Mehdi , Osborne Michael J. , Prokop Jeremy W. , McDonald Paul C. , Karar Jayashree , Hou Zhaoyuan , He Mei , Kebebew Electron , Orntoft Torben , Herlyn Meenhard , Caton Andrew J. , Fredericks William , Malkowicz Bruce , Paterno Christopher S. , Carolin Alexandra S. , Speicher David W. , Skordalakes Emmanuel , Huang Qihong , Dedhar Shoukat , Borden Katherine L.B. , Rauscher Frank J.
Published: April 2023

Both aLIMD2 (rAb) and aLIMD2 (mAb) detected the exogenous and endogenous LIMD2 protein in cell lines and human cancer specimens.
Supplementary Methods from A Novel Class of Anticancer Compounds Targets the Actin Cytoskeleton in Tumor Cells
Authors: Stehn Justine R. , Haass Nikolas K. , Bonello Teresa , Desouza Melissa , Kottyan Gregg , Treutlein Herbert , Zeng Jun , Nascimento Paula R.B.B. , Sequeira Vanessa B. , Butler Tanya L. , Allanson Munif , Fath Thomas , Hill Timothy A. , McCluskey Adam , Schevzov Galina , Palmer Stephen J. , Hardeman Edna C. , Winlaw David , Reeve Vivienne E. , Dixon Ian , Weninger Wolfgang , Cripe Timothy P. , Gunning Peter W.
Published: April 2023

PDF file - 129K, Supplementary Experimental Methods: Animal studies: Detailed methods outlining the in vivo TR100 animal studies. Tropomyosin compound modeling: Detailed method outlining the in silico modeling of Tm5NM1.
Supplementary Methods from Apoptosis Imaging for Monitoring DR5 Antibody Accumulation and Pharmacodynamics in Brain Tumors Noninvasively
Authors: Weber Thomas G. , Osl Franz , Renner Anja , Pöschinger Thomas , Galbán Stefanie , Rehemtulla Alnawaz , Scheuer Werner
Published: April 2023

PDF file - 63KB, Fluorescence imaging - Fluorescence imaging was used for monitoring anti-DR5-Cy5 distribution in the mouse. Cell culture and cell inoculation of U87-Luc and U251 cell lines - U87-Luc and U251 were used for additional BBB penetration studies and were inoculated as described for D54-Caspase-3/7 GloSensor cell line.
Supplementary Figure Legend from Novel Mechanism of MDA-7/IL-24 Cancer-Specific Apoptosis through SARI Induction
Authors: Dash Rupesh , Bhoopathi Praveen , Das Swadesh K. , Sarkar Siddik , Emdad Luni , Dasgupta Santanu , Sarkar Devanand , Fisher Paul B.
Published: April 2023

PDF file - 66K
Supplementary Table 1 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: April 2023

PDF file - 282K, SUPPLEMENTARY TABLE 1. List of EV proteins identified by mass spectrometry.
Supplementary Figure 2 from Extracellular Vesicles Modulate the Glioblastoma Microenvironment via a Tumor Suppression Signaling Network Directed by miR-1
Authors: Bronisz Agnieszka , Wang Yan , Nowicki Michal O. , Peruzzi Pierpaolo , Ansari Khairul I. , Ogawa Daisuke , Balaj Leonora , De Rienzo Gianluca , Mineo Marco , Nakano Ichiro , Ostrowski Michael C. , Hochberg Fred , Weissleder Ralph , Lawler Sean E. , Chiocca E. Antonio , Godlewski Jakub
Published: April 2023

PDF file - 168K, FIGURE S2 related to FIGURE3. Effect of miR-1 overexpression on GBM cells in vitro.