bluuebunny/crossref_metadata_2025 huggingface dataset:
Aging behavior of three-proof polyurethane coatings under UV radiation
Authors: Wang Jianfa , Gu Zheng , Zhao Jie , Zhang Susu , Li Peiyao , Meng Chao , Sui Jinyong , Zhang Xiaoyi , Hu Shaokai , Pan Jiaying , Li Junyi
Published: November 2022

The influence of UV radiation on the physical and mechanical properties of polyurethane resins and three-proof polyurethane coatings was examined. Changes of mechanical properties and the gloss of resins and coatings were determined. The structure of materials was confirmed using scanning microscopy SEM and Fourier transform infrared spectroscopy FTIR; thermogravimetric TGA and DTG studies were also performed. It turned out that the gloss of finished protective coatings was worse than the gloss of individual resins, and aging significantly lowered these values (from 81.3° to 8.9° in case of resins and from 61.1° to 2.8° in case of coatings after 1200 hours of irradiation). Tensile strength of resins decreased constantly during aging while their elongation at break decreased than increased reaching minimum at exposure time of 100 hours. In case of coatings, both tensile strength and elongation at break firstly decreased than increased reaching minimum at exposure time of 800 hours; after long exposure time, more than 1200 hours, these properties decreased again.
CSR vs. Value Creation: What Relationship? An Overview of the Literature
Authors: EL BADRI Lamia , AASRI Mohammed Rachid
Published: November 2022

Social and Environmental Responsibility represent nowadays an opportunity to be seized by a Companies to improve their competitive market position and to achieve their best level of performance and thereby create value. This article aims to analyze the different approaches that have demonstrated the existence of a link between CSR (Corporate Social Responsibility) and value creation, through a literature review and a conceptual framework.
DISPARITAS PEMIDANAAN DALAM KASUS TINDAK PIDANA KHUSUS NARKOTIKA DI PENGADILAN NEGERI TANGERANG
Authors: Romdoni Muhamad , Fitriasih Surastini
Published: November 2022

Disparitas pemidanaan di Pengadilan Negeri Tangerang berpotensi menimbulkan ketidakadilan dan ketidakpastian hukum bagi para pelaku tindak pidana narkotika. Penelitan ini bertujuan untuk melihat disparitas di Pengadilan Negeri Tangerang dan penyebab hakim menjatuhkan pidana penjara dari pada rehabilitasi.  Penelitian ini menggunakan metode yuridis normatif melalui pendekatan perundang-undangan dan pengkajian yang dilakukan terhadap 20 putusan yang dipilih secara purposive. Hasil penelitian menunjukkan, pertama, telah terjadi Disparitas pemidanaan pada putusan terhadap pelanggaran Pasal 112 ayat (1), 114 ayat (1), 127 ayat (1) huruf a UU Narkotika. Kedua, faktor penyebab hakim menjatuhkan pidana penjara. Dari sisi subtansi hukum, perbuatan Terdakwa yang mengandung unsur-unsur Pasal 112, 114 dan 127 UU Narkotika memberikan peluang memilih pasal sesuai kehendak hakim. Dari sisi penegak hukum yang masih mengedepankan rasa efek jera melalui sanksi penjara.
How to best use procalcitonin to diagnose infections and manage antibiotic treatment
Authors: Schuetz Philipp
Published: November 2022

Objectives

Procalcitonin (PCT) is a host-response biomarker that has shown clinical value for assessing the likelihood of bacterial infections and guiding antibiotic treatment. Identifying situations where PCT can improve clinical care is therefore highly important.

Methods

The aim of this narrative review is to discuss strategies for the usage and integration of PCT into clinical routine, based on the most recent clinical evidence.

Results

Although PCT should not be viewed as a traditional diagnostic marker, it can help differentiate bacterial from non-bacterial infections and inflammation states – particularly in respiratory illness. Several trials have found that PCT-guided antibiotic stewardship reduces antibiotic exposure and associated side-effects among patients with respiratory infection and sepsis. Studies have demonstrated that patient-specific decisions regarding antibiotic usage is highly complex. Factors to consider include: the clinical situation (with a focus on the pretest probability for bacterial infection), the acuity and severity of presentation, as well as PCT test results. Low PCT levels help rule out bacterial infection in patients with both low pretest probability for bacterial infection and low-risk general condition. In high-risk individuals and/or high pretest probability for infection, empiric antibiotic treatment is mandatory. Subsequent monitoring of PCT helps track the resolution of infection and guide decisions regarding early termination of antibiotic treatment.

Conclusions

PCT possesses high potential to improve decision-making regarding antibiotic treatment – when combined with careful patient assessment, evidence-based clinical algorithms, and continuous notification and regular feedback from all antibiotic stewardship stakeholders. Medical Journals such as Clinical Chemistry and Laboratory Medicine (CCLM) have played a critical role in reviewing and dissemination the high-quality evidence about assays for PCT measurement, observational research regarding association with outcomes among different populations, and interventional research proofing its effectiveness for patient care.
Tracking subject position change in U.S. Southwest Spanish: what 19th and 20th century Tucson newspapers tell us
Authors: Cerrón-Palomino Álvaro , Vana Rosti
Published: November 2022

This study explores convergence in subject position in U.S. Southwest Spanish at the outset of its extensive contact with English. The data analyzed come from two Spanish newspapers published in Tucson, Arizona, in the years following the city’s annexation to the United States through the Gadsden Purchase in 1854:El Fronterizo(1878–1914) andEl Tucsonense(1915–1957). During this period of early language contact, the Hispanic population in Tucson faced a gradual process of anglicization that changed its status from majority in 1880 (63.8%) to minority in 1940 (29.9%). If there were structural convergence between the languages at stake, then there should be an English-driven gradual decrease across time in the postverbal subject use exhibited in the newspapers studied, as heritage varieties of Spanish develop. However, regressions with Rbrul show that, in the period analyzed, the probability of using postverbal subjects was not affected by the passing of time. Moreover, regression analyses show that the linguistic constraints affecting subject position in historical Tucson Spanish are basically the same that condition the variable in contemporary varieties: absence of a postverbal phrase, sentential subjects, presence of a preverbal phrase, unaccusative verbs, animate subjects and heavy subjects. This study also shows that the weakest factor groups in contemporary varieties of Spanish started their declining process at least a century ago.
Language contact in historical documents: the identification and co-occurrence of Egyptian transfer features in Greek documentary papyri
Authors: Dahlgren Sonja , Keersmaekers Alek , Stolk Joanne
Published: November 2022

The Egyptian-Greek contact situation has lasted almost a thousand years and many documents have been preserved to us from this period. In this paper, we apply a new quantitative approach to this rich corpus of documentary papyri to map the relationships between the linguistic variables (the variant spellings) and several non-linguistic variables. A multidimensional scaling of the co-occurrences of the linguistic variables shows that there is a strong association between most of the Greek variant spellings that can be explained by Egyptian phonological transfer, while others do not typically co-occur with them. Several new linguistic variables not yet connected to Egyptian phonological transfer also show a strong relation with the first group of features, some of them representing the same phonological transfer processes. A comparison of the contexts in which these variables are used allows us to further substantiate this observation: several of the previously and newly Egyptian-associated variables turn out to have a strong correlation with bilingual Egyptian-Greek documents or occur in Egyptian dominated environments. The spelling variants are chronologically dependent and different features are typically associated with different historical periods illustrating changes taking place in the Egyptian Greek contact variety over time. A multiple correspondence analysis shows that the variables strongly interact, illustrating the importance of a multifactorial approach combining various linguistic and non-linguistic factors.
The rationalisation of vowel diacritic spelling in Early Modern English (1500–1700)
Authors: Condorelli Marco
Published: November 2022

During the sixteenth and the seventeenth centuries, a number of spelling solutions gradually became established in English as ways to indicate vowel quality, namely whether a vowel sound was different from another, and vowel quantity, that is to say whether a vowel was long or short. Among the solutions that arose to indicate vowel quality,  and  were introduced for spellings like sea and boat. For vowel quantity, ‘single’ consonants in pairs like  and ,  and , as well as  and  began to be used for immediately preceding long vowels. My contribution explores all of the examples of vowel diacritic spelling mentioned above in printed English between 1500 and 1700, using a quantitative model for the analysis of patterns across a range of texts from Early English Books Online. The analysis shows an overall process of standardisation occurring between the sixteenth and the seventeenth centuries, and provides fresh insights into the lexical distribution for the standardisation of vowel diacritic spelling. The discussion reflects upon the development of the spellings, and argues for pragmatic factors within the Early Modern English printing industry as responsible for their modern standardisation.
Non-syntactic factors and accessibility to relativization: evidence from Armenian
Authors: Hodgson Katherine
Published: November 2022

Data presented by Sakayan (Sakayan, Dora. 1993. On Armenian relative participles and their access to AH (Accessibility Hierarchy). In André Crochetière, Jean-Claude Boulanger and Conrad Ouellon (eds.), Proceedings of the XVth International Congress of Linguists, Université Laval, 1992, vol. 2, 361–364. Sainte-Foy, Québec: Université Laval Press) show that Modern Eastern Armenian appears to violate the Relativization Accessibility Hierarchy (Keenan, Edward and Bernard Comrie. 1977. Noun phrase accessibility and universal grammar. Linguistic Inquiry 8. 63–99), as participial relative clauses may be used to relativize certain oblique and genitive elements, but apparently not indirect objects. Stimuli were constructed to elicit relative clauses on all positions in the hierarchy to investigate whether participial relativization violates the hierarchy and shed light on the factors affecting relativization accessibility phenomena. Two different manifestations of the Accessibility Hierarchy (AH) were investigated: the distribution of participial relative clauses (RCs), and ‘non-target’ responses, in which the relativized element is expressed with a grammatical relation other than that which is targeted by the stimulus. The results show that the hierarchies for these two manifestations are significantly different. If the AH effects were a mechanical reflex of syntactic structure, we would not expect to find these differences. In fact, it appears that different factors are dominant in each case, notably role-reference association for non-target responses, and role prominence in terms of topicality and affectedness for participial relativization. The fact that participles are not normally used for indirect object (IO), while they may be used for some obliques and genitives, makes sense when the AH effects are analyzed as the combined operation of a number of factors, rather than a mechanical reflex of syntactic structure, and indeed, in colloquial language, participles may be used for IO under some circumstances, for example when it is the undisputed primary topic. Thus there is good evidence that non-syntactic factors are key to the operation of the AH in its various manifestations, and can account for this supposed violation.
A PRODUÇÃO DO ESPAÇO NA CIDADE PEQUENA E AS RELAÇÕES DE SOCIABILIDADE EM SÃO FELIPE/BA
Authors: Cerqueira Leandro Maiara
Published: November 2022

Ao problematizar a produção do espaço da cidade pequena, destaca-se a necessidade de apreender as particularidades e contradições socioespaciais reproduzidas nesses pequenos centros urbanos, sem perder de vista as transgressões realizadas pelas práticas cotidianas e pelo vivido. O objetivo é discutir o processo de produção do espaço na cidade pequena articulado à análise das relações de sociabilidade e apropriação do espaço vivido em São Felipe2. Os procedimentos metodológicos pautaram-se na construção da discussão teórico-metodológica; uso de entrevista semiestruturada e questionários; mapeamento, organização e sistematização das informações; e, análise dos resultados. A pesquisa revelou que as relações de sociabilidade reproduzidas em São Felipe são compartilhadas entre os sujeitos de forma mais próxima e, mediadas por conflitos em meio às ambiguidades dos discursos e representações do vivido.
EXPERIMENTAÇÃO E HISTÓRIA DE UM FAROL
Authors: De Oliveira Nunes Gustavo , Silva Moraes Adriane Cristhine
Published: November 2022

Este ensaio apresenta uma leitura cartográfica acerca de uma pequena localidade conhecida como Farol de Santa Marta, situada no litoral de Santa Catarina. O objetivo é trazer à tona um pouco da aura local, perguntando-se: Como se deu o processo de povoação e urbanização desse lugar? Para respondê-la, este ensaio segue pistas do método da Cartografia, apresentando-se em dois planos: o dos trajetos intensivos e o dos trajetos extensivos. Nos intensivos, narra-se uma viagem e a tentativa de expressão das forças do território através de pinturas em aquarela. Nos extensivos, a narrativa se ocupa em compreender a gênese do local, suas marcas e transformações, através de um arquivo histórico e antropológico. Como resultado, tem-se uma abordagem em que não se separa a sensação que surge na experiência e a pesquisa histórica e antropológica. Produz-se, assim, um sentido para a vontade de saber que nasce do encontro e experimentação.
BACURAU
Authors: Reys Paulo , Pavan Detoni Luana , Boeira Bittencourt Lucas , Silva Lopes Fernandes Gabriel
Published: November 2022

Este ensaio discute a realidade das cidades pequenas tal qual representada no filme Bacurau. A questão posta como problema é como essas imagens em movimento nos convidam a refletir a partir de uma perspectiva estética e política. Essa obra nos instiga a pensar o urbano a partir de uma outra perspectiva — a cidade pequena ou, ainda, o lugar menor. Em contextos contra-hegemônicos, se justificam reflexões que invertam a lógica hegemônica neoliberal. O objetivo é pensar pautas que emergem no filme em questão que expressam realidades das cidades pequenas. A aproximação metodológica reside no enfrentamento teórico a partir das noções de estética e política em Jacques Rancière e na noção de menor em Gilles Deleuze e Félix Guattari. Esperamos alçar questões que evidenciam a realidade desse outro urbano. Acreditamos que é na esfera estética e política que esse outro urbano possa se manifestar como uma questão relevante de pesquisa.
CIDADES PEQUENAS E AGRICULTURA URBANA NO CONTEXTO DA PANDEMIA COVID-19
Authors: Girotti Sperandio Ana Maria , Bonetto Barbara , Fraga Lima Tailana , Conceição Guarnieri Jussara
Published: November 2022

Na pandemia COVID-19, iniciativas envolvendo estratégias de agricultura urbana foram implementadas ou expandidas, sistemas de abastecimento e transformação dos territórios urbanos são tópicos frequentes de pesquisa e reflexão atuais. A cidade de Conchal/SP traz exemplos de práticas de cidades saudáveis, incorporadas ao seu território, gestão pública e planejamento urbano e suas experiências podem ser estudadas para replicação em outras cidades pequenas. Este artigo tem como objetivo identificar e destacar convergências da agricultura urbana e premissas das cidades saudáveis, na perspectiva do enfrentamento da pandemia e suas consequências e que contribuam para o planejamento urbano nas cidades pequenas. A pesquisa consiste em um estudo descritivo com uma abordagem qualitativa e exploratória. A agricultura urbana e recuperação de vazios urbanos em projetos comunitários podem ser pensadas no contexto do enfrentamento da insegurança alimentar agravada pela pandemia, na esfera do planejamento urbano baseadas nas premissas das cidades saudáveis.
Impact of DC glow discharge plasma treated Ti doped hydroxyapatite nanomaterials using antibacterial and cytotoxicity applications
Authors:   Research Scholar, Centre for Research and Evaluation, Bharathiar University, Coimbatore, Tamilnadu 641046, India, Sri Devi P. , Vijayalakshmi K. A. ,   Sri Vasavi College, Erode, Tamilnadu 638316, India
Published: November 2022

In this work we developed Ti doped hydroxyapatite with were synthesized by using a solgel technique with exposed to DC glow discharge plasma with different times treated. The pure and Ti/HAp were characterised by using different characterizations like XRD, FTIR, SEM, EDAX, UV-visible, PL, TG-DTA, antibacterial activity, 3T3 fibroblast cells and MCF-7 breast cancer cell line with cytotoxity efficiency analysis. The pure HAp and Ti/HAp materials had a nanocube and nanoflakee shape in the SEM results. In the ultraviolet-visible light (UV-vis) spectrum, the band edge absorption of bare HAp and Ti/HAp samples is discovered at wavelengths of 295 nm and 328 nm, respectively. The antibacterial activity of untreated and plasma-treated pure HAP and Ti/HAp samples are tested against two gram-positive bacteria, Bacillus cereus and Staphylococcus aureus, as well as two gram-negative bacteria, E. coli and Pseudomonas aeruginosa, using the agar well diffusion technique. The MTT assay was used to investigate the mean per cent (% percent) cell survival of Ti/HAp at various concentrations (6 mg/mL; 85 mg/mL) against 3T3 fibroblast cells and human MCF-7 Breast cancer cell lines. The synthesised Ti/HAp biocompatibility makes it a viable contender for future biological uses.
Comparison of Students' Ability to Work Inventory Questions at SMK Negeri 1 Pulutan
Authors: Pakpahan Dandi , Hodsay Zahruddin , Toyib M.
Published: November 2022

This study aimed to determine whether there is a comparison of students' abilities in working on inventory questions at SMK Negeri 1 Pemulutan. The subjects in this study were students of class XII Accounting at SMK Negeri 1 Pemulutan, from 98 students 66 students were taken to be used as research samples. Data collection techniques were documentation and tests, with the instrument in the form of test questions—the data analysis technique used one-way ANOVA (one-way ANOVA or F test) using SPSS version 22. From the results of the analysis using the F test with SPSS version 22, the F-count was 4.086, and the F-table of 3.15 with a dk of 66 and a significance level of 5%. Because F-count was greater than F-table (4.086 > 3.15), Ho was rejected and Ha was accepted. The average student test results in solving inventory questions using the FIFO method was 85.27, LIFO was 81.10, and AVERAGE was 74.65. This showed that there was a comparison of students' abilities in working on inventory questions at SMK Negeri 1 Pemulutan, as well as in the process of working on the easy method, namely the FIFO method, and the difficult method, the Average method.
Model of Innovation Capability and Competitive Advantage of Tourism SMEs During Covid-19 Pandemic
Authors: Feriady Muhammad , Farliana Nina
Published: November 2022

This study aimed to determine the role of innovation capability in mediating the internal factors of MSMEs towards competitive advantages during the Covid-19 pandemic. This study used a quantitative approach, involving 243 MSMEs in the tourism sector in Semarang Regency, Central Java, Indonesia as research respondents. Methods of data collection used a questionnaire. The data analysis method used partial least square structure analysis using SmartPLS. The results of this study found a strong role of innovation capability in mediating entrepreneurial orientation and social capital on the competitive advantage of tourism MSMEs. There was a positive and significant effect between innovation capability and competitive advantage with an estimated weight of 45 percent of innovation capability which could explain the variation of competitive advantage. The competitive advantage of MSMEs during the pandemic was determined by social capital and also entrepreneurial orientation. The recommendation that can be given from this research is the model of innovation capability should be more exploration for research in another sector of MSMEs
Productive Capacity of Ukraine’s Economy and its Regions in Terms of Social Dimensions in War Conditions
Authors: Karpiak Maria , Popadynets Myroslava
Published: November 2022

The article deals with the issue of human potential as the basis for the growth of the state's productive capacity both on the domestic and international markets, and as a whole, the basis for the socio-economic progress of society. Russia's unprecedented invasion of Ukraine and the deployment of a full-scale war on the territory of our country led to immediate changes in the demographic situation of the country, which in turn caused corresponding consequences for the economy, which will be felt for a long time. Since the beginning of the war, more than 6 million people have left the territory of Ukraine, approximately 7.7 million were forced to leave their homes and became internally displaced persons. Despite a considerable amount of research, today the issue of preserving the human potential of Ukraine remains especially relevant in the conditions of Russian aggression. Thus, the purpose of this article is to outline the current problems of the loss of human potential as a result of Russian aggression, the formation of opportunities and the search for ways to preserve and reproduce it, as well as the implementation of an effective scenario for the management of human potential both at the national and regional levels. The article examines the essence of the human potential category, defines the author's interpretation of the content of this category. Certain assumptions are also made regarding the economic prospects and the determining role of the demographic factor for the further economic future of Ukraine. The main ways to preserve the human potential of the state, as well as its further reproduction in the conditions of post-war economic recovery, are outlined. It is substantiated that in the future, after the stage of reconstruction is completed in the Ukrainian economy and it enters the path of gradual development, human capital will play a decisive role. In the long-term perspective, namely on the scale of several decades, the demographic factor may become decisive for the development of Ukraine's economy. Today, in Ukraine, the categories of human potential and human development as interdependent and complementary categories, which are closely correlated with each other, are forced to function in the coordinate system of military-economic relations. Therefore, the modern economic policy of the state requires the strengthening of measures not only of the military-economic, but also primarily of social-cultural and moral-ethical development of human potential within the country, in particular, its effective strategic management in the processes of forming the priorities of foreign economic activity and the Euro-Atlantic perspective.
Assessment of an Exchange Rate’s Fluctuations Impact on the Foreign Exchange Market
Authors: Solodzhuk Tetiana , Myhovych Tetiana
Published: November 2022

The article analyzes the foreign exchange market functioning under the influence of exchange rate fluctuations. The main factors determining the exchange rate in the existing conditions have been determined. All course-forming factors are divided into fundamental ones, which include the main economic indicators; technical conjunctural; extraordinary (unexpected) and non-economical. The formation of the forward currency operations market trends, in particular forward contracts, currency swaps, options and other financial instruments, was also investigated. The income trends of the current currency market from quotes of the most used currency pairs are briefly described.It was concluded that the most predictable indicator in the current currency operations market is the standardized exchange rate, determined on the basis of currency quotes of at least 6 commercial banks. When calculating the average arithmetic rate, the highest and lowest quotation rates are not taken into account.The future foreign exchange market trends depend on the choice of the monetary policy vector, which is based on a qualitative and quantitative assessment. Since the processes in the currency market have a fractal structure and cannot be predicted using classical methods, the provisions of the fractal statistics theory are used for this purpose.In particular, on the basis of existing quotations of the currency pair US dollar/Ukrainian hryvnia, the Hurst indicator, which reflects the level of anti-persistence of the national currency exchange rate dynamics, was calculated, and accordingly, its ability to change trends to the opposite in periods of high volatility and in the presence of factors that cause it. The volatility of the national currency rate and the level of anti-persistence of currency fluctuations depends on a number of measures in the field of currency regulation and currency and monetary policy. At the same time, any intervention of the state government in the exchange rate formation process causes a change in the trend. The results of the calculations can be used for operational and strategic planning of the business entities behavior on currency markets and measures aimed at countering the negative impact of exchange rate changes.
Prospects of Integration of the Ukrainian Economy into the European Economic Area
Authors: Zhytar Maksym , Lisnichuk Oksana
Published: November 2022

The article examines the prospects for the integration of the Ukrainian economy into the European economic space. It has been established that Ukraine's accession to the EU would be beneficial not only for Ukraine, but also for the European Union itself. One obvious advantage is security: if Ukraine were not currently at war, Russian tanks would probably already be in Warsaw or Tallinn. In peacetime, there are many opportunities for cooperation. Obvious areas are food security and energy production; in addition, Ukraine has a lot of human capital and entrepreneurial talent, and it is quite developed in IT, mechanical engineering and other industries that require a high level of technical skills. Ukrainian culture is rich and original. However, not only Ukraine will change during the accession. The European Union itself will be reformed in response to new challenges.Existing agreements between Ukraine and the European Union have already contributed to significant trade flows. Accession will have greater implications for the free movement of capital and workers – investment inflows and migration outflows. These areas are likely to be the focus of negotiations.A certain accession agreement usually has transition periods, especially for full free movement of labor, and opt-out clauses. The essential difference will be that Ukraine will be granted the status of "member of the EU" and not associated or annexed status.The consequences of the Russian invasion of Ukraine and its request for membership in the European Union changed the role of international diplomacy. The European Union realized the need to strengthen its own security and solve internal problems - from the consequences of Brexit to solving the alleged violations of the rule of law by Hungary.The military incursions into Ukraine have become a catalyst for change across Europe, and this may be reflected in how the member states of the European Union and the European Commission deal with Ukraine's accession.
Computational electromagnetic analysis of partially-filled rectangular waveguide at X-band frequencies
Authors: Zamaraite Ilona , Rudys Saulius , Lapinskas Saulius , Aleksiejunas Rimvydas , Grigalaitis Robertas , Banys Juras
Published: November 2022

In this paper, the full-wave analysis of the direct scattering problem in the rectangular waveguide is derived. The numerical calculation results of the scattering characteristics are presented. To show the advantage of our proposed model, we compared direct problem results with three-dimensional simulation software Ansys HFSS calculations. An excellent agreement is observed when compared these two approaches.
Housing Problem in Ukraine on the Background of War 2022
Authors: REUT A. G. , KOHATKO Yu. L.
Published: November 2022

The purpose of the article is to identify the most acceptable anti-crisis actions and decisions in the housing sphere during military conflict, as well as to evaluate the possibility of their use as a foundation in the formation of state housing policy in the postwar years. The urgency of monitoring the impact of war on the situation in the housing sphere and the study of existing international experience and unique for Ukraine practices on providing the population with housing in crisis conditions is undeniable due to the loss of housing by hundreds of thousands of Ukrainians. In the course of the study, to define the most acceptable anti-crisis actions and decisions in the housing sphere during the military conflict, we used methods of qualitative, comparative analysis, statistical and calculation methods. A review of the most successful international practices in solving housing problems in crisis situations was carried out and the possibility of their application in Ukraine in war conditions was analyzed. The scale of the loss of housing stock and infrastructure, primarily in the regions where active hostilities took place, was studied. The main ways of providing access to temporary and permanent housing for the population that suffered property losses due to the war are identified. The ability of the state, depending on the chosen path, to solve the housing issue for internally displaced persons and for the population whose housing was destroyed was analyzed. It was revealed that the most likely approach to providing the population with temporary housing is the use of rapid construction technologies, in particular, modular houses. Based on the simulation, the ability of the population from regions where hostilities took place / are ongoing to independently provide themselves with housing by renting or buying real estate in safer regions was assessed. It was revealed that the vast majority of the population has the opportunity to solve the housing problem with the help of a short lease, but the further continuation of the war will significantly reduce their ability to afford it. It was also found that as a result of the war, the availability of housing purchases decreased for Ukrainians. Consequently, the population of Ukraine, regardless of the region of residence, is mainly not able to independently solve the housing problem without the support of the state.
Social Assistance Provision to Displaced Persons on the Principle of Social and Labor Inclusion
Authors: PEREHUDOVA T. V.
Published: November 2022

The article is devoted to the issues of further social integration of internally displaced persons (IDPs) on the basis of institutional reduction of social exclusion of this category of the population, which requires improvement of legal regulation of their social protection by strengthening cooperation between such institutions as the State Employment Service of Ukraine. Overcoming the extractive nature of the national labor market requires social and labor inclusion, which involves the process of participation of employable citizens, including IDPs, in socially useful activities by forming a system of incentives for reintegration into the labor market and creating conditions for the realization of labor potential. In connection with these issues, there was a study of the legal framework for social protection of IDPs in Ukraine which proposes a model for calculating social assistance to IDP workers in social and labor inclusion. To achieve this goal, the following general and special methods are used: the method of theoretical generalization, systematic, dialectical method of scientific comprehension in the process of determining the approach to the provision of social assistance to IDPs; historical and logical analysis - in the study of social protection; comparative analysis, synthesis and generalization - in research on the practice of social support for the population to enter the labor market; methodological and functional analysis - to determine the directions of institutionalization of social protection of IDPs. Weaknesses in the procedure for providing financial assistance to able-bodied IDPs have been identified, including: artificial determination of the amount of financial assistance; the lack of correlation between the amount of financial assistance and social standards; the discrepancy between the amount of Unified Social Contribution paid by IDP staff, salaries and the amount of cash benefits. According to the author, the improvement of social assistance to IDP workers is possible by identifying two components: non-compensatory, which is tied to the subsistence level, and compensatory, which is tied to the amount of wages. This approach stimulates official employment and forms the preconditions for the development of social insurance in Ukraine.
THE STATE OF LONG-TERM AUTOIMMUNE AND INFLAMMATORY REACTIONS AFTER COVID-19
Authors:   SI “Institute of Neurosurgery of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine, Lisyany M.I. , Belskaya L.M. ,   SI “Institute of Neurosurgery of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine, Klyuchnikova A.I. ,   SI “Institute of Neurosurgery of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine, Krasilenko E.P. ,   SI “Institute of Neurosurgery of the National Academy of Medical Sciences of Ukraine”, Kyiv, Ukraine
Published: November 2022

The purpose of this work was a comparative study of the state of inflammatory reactions and the level of autoantibodies to neuroantigens in COVID-19 previously infected and vaccinated persons. People who have experienced a COVID-19 infection had an increased level of CRP, medium-mass molecules, in their blood serum. This indicates the persistence of a long-term inflammatory reaction after the infection. The level of autoantibodies to neuroproteins in blood sera was increased both in the groups of COVID-19 previously infected and vaccinated patients in comparison with persons who have not undergo the disease. This indicates the activation of humoral neuroautoimmune reactions, which can lead to the activation and development of progressive neurological complications in a remote period after infection. The level of anti-covid antibodies was 2-3 times higher in vaccinated than in COVID-19 previously infected persons, in the last group both high and low titers of antibodies were registered. This indirectly indicates possible re-infection and the need to vaccinate persons who already had experienced the infection. Subjects who have not suffered from COVID-19 show lower signs of intoxication, inflammation, and levels of neuroautoantibodies occurred if compare to other groups. In addition, the titer of specific anticovid antibodies was significantly low; this indicates a lack of humoral immunity to the COVID-19 virus. The reasons and mechanisms of such a “resistance” to infection are unclear and represent a certain scientific and practical interest for further study.
Vitamin D alters the transcriptional profile of blood cells in patients with primary hypothyroidism
Authors:   I. Horbachevsky Ternopil National Medical University, Ukraine, Kamyshna I.I. , Pavlovych L.B. ,   Bukovinian State Medical University, Chernivtsi, Ukraine, Kamyshnyi A.M. ,   I. Horbachevsky Ternopil National Medical University, Ukraine
Published: November 2022

Our work aimed to study the influence of cholecalciferol on neurogenesis, neurotrophins and their receptors pathway-focused genes expression in patients with autoimmune thyroiditis and hypothyroidism. The pathway-specific PCR array (Neurotrophins and Receptors RT2 Profiler PCR Array, “QIAGEN”, Germany) was used to identify and validate the neurogenesis regulatory genes expression in patients with thyroid pathology and control group. The results showed that in patients with autoimmune thyroiditis-caused primary hypothyroidism, the expression of BDNF, FAS, FGF2, HSPB1, IL10, NGF, NGFR, NRG1, NTF3, NTF4, TGFB1, and TP53 were increased after treatment with cholecalciferol and L-thyroxine. The mRNA levels of BAX, GDNF, CD40, FOS, GDNF, GFRA1, IL1B, and STAT3 were significantly decreased in patients with autoimmune thyroiditis-caused primary hypothyroidism after treatment with cholecalciferol and Lthyroxine compared to the patients who received only L-thyroxine. Therefore, the addition of vitamin D to standard therapy alters the transcriptional profile of blood cells in patients with primary hypothyroidism.
THE TRIGGER COMPONENTS OF THE PROTEOLYTIC SYSTEM AND THEIR MODULATORS CONTENTS UNDER PANCREATIC PATHOLOGIES DEVELOPMENT
Authors:   Taras Shevchenko National University of Kyiv, Educational and Scientific Centre “Institute of Biology and Medicine”, Ukraine, Synelnyk T.B. , Kravchenko O.O. ,   Taras Shevchenko National University of Kyiv, Educational and Scientific Centre “Institute of Biology and Medicine”, Ukraine, Kostiuk O.S. ,   Taras Shevchenko National University of Kyiv, Educational and Scientific Centre “Institute of Biology and Medicine”, Ukraine, Savchuk O.M. ,   Taras Shevchenko National University of Kyiv, Educational and Scientific Centre “Institute of Biology and Medicine”, Ukraine, Sukhodolia S.A. ,   National Pirogov Memorial Medical University of Vinnytsya, Ukraine, Ostapchenko L.I. ,   Taras Shevchenko National University of Kyiv, Educational and Scientific Centre “Institute of Biology and Medicine”, Ukraine
Published: November 2022

The content of the plasminogen activation system components (plasminogen, plasminogen tissue activator, and its inhibitor PAI-1) was investigated as well as the concentration of thrombomodulin, protein C, matrix metalproteinases (MMP -1, -2, -3, -8, -9, -10) and their inhibitor TIMP, growth factors content (such as transforming growth factor-β1, insulin-like growth factor-1, fibroblasts growth factor-2) and cytokine profile (interleukines IL-1β, -4, -6, -8, -10, tumor necrosis factor, interferon-γ in patients with chronic pancreatitis (CP) and pancreatic cancer (PC) were established. Khmelnitsky Regional Clinical Hospital patients aged 28-89 were selected for this study: 20 people with chronic pancreatitis (group CP); 20 people with pancreatic cancer (group PC); 20 conditionally healthy persons (control). Blood plasma samples and pancreatic tissue homogenates were obtained from all the patients. The studied indicators’ content in the experimental materials was determined by the enzyme-linked immunosorbent assay using appropriate antibodies. At the level of systemic circulation, a statistically significant increase was found in most of the studied parameters under the CP conditions. However, PC was characterized by an increase of two blood plasma indications only (thrombomodulin and protein C). In contrast, the pancreatic sample tissue examination for both aforementioned pathologies revealed significant changes in the content of most metalloproteinases and cytokines under PC. This indicates the development of metastasis, angiogenesis, and immunomodulation-aimed local biochemical processes in the affected organ.
THE EFFECT OF MESENCHYMAL STEM CELLS INJECTION ON THE STRUCTURE AND FUNCTION OF CEREBRAL HEMISPHERES NEUROPIL OF RATS WITH EXPERIMENTAL NITRITE-INDUCED DEMENTIA
Authors:   Kharkiv National Medical University, Ukraine, Lukyanova Ye.M. , Pavlova O.O. ,   Kharkiv National Medical University, Ukraine, Gubina-Vakulik G.I. ,   Kharkiv National Medical University, Ukraine, Gorbach T.V. ,   Kharkiv National Medical University, Ukraine
Published: November 2022

The cerebral hemispheres neuropil of rats with experimental nitrite-induced Alzheimer’s type dementia was studied after mesenchymal stem cells (MSC) introduction. Rats were injected with an aqueous solution of sodium nitrite (50 mg/ kg) for 14 (group 1) and 28 days (group 3), and half of them additionally got intravenously MSC (500000 cells per rat) (groups 2 and 4). The control group received saline in the same way. The acetylcholine level, TBA-active substances contents, catalase and superoxide dismutase activities in brain homogenates, and the content of 2,3-diphofoglycerate (2,3- DFG) in erythrocytes were measured spectrophotometrically. Brain slices were stained with Congo red and according to the Einarson method. They were then examined on an Axiostar plus binocular microscope (“Zeiss”, Germany). The optical density of the cerebral hemispheres neuropil had been measured. In all experimental groups, an increase in the content of 2,3-DFG in erythrocytes and an imbalance in the pro- and antioxidant system, oxidative stress development in brain were observed. The neuropil structure of the cerebral hemispheres was changed: we observed focal zones of neurofilaments degeneration and atrophy and amyloid accumulation, especially in group 3. The optical density of neuropil was reduced; this was accompanied by a decrease in the content of acetylcholine. MSC injections resulted in a significant increase in the content of acetylcholine, decrease in the brain oxygen demand and the content of TBA-active substances. Consequently, prolonged sodium nitrite administration leads to the cerebral hemispheres neuropil structure and functional injury. MSC introduction contributes to the improvement of the neuropil morphofunctional state.
INFLUENCE OF SEROTONIN ON THE METABOLISM OF BONE TISSUE
Authors:   Bogomolets Institute of Physiology of the National Academy of Sciences of Ukraine, Ukraine, Litovka I.G.
Published: November 2022

This literature review presents data on the influence of serotonin on the metabolism of bone tissue. The mechanisms by which serotonin affects the formation and resorption of bone, depending on the site of synthesis (central or peripheral), as well as the cells and receptor subtypes that are activated, have been considered. A number of issues for further research are highlighted, in particular, the dose-response relationship and side effects during chronic and long-term treatment with various selective serotonin reuptake inhibitors.
Correlation Between Physical Activity, Body Composition, And Micronutrition Intake In Patients Of Knee Osteoarthritis At The Medical Rehabilitation Clinic, Fatmawati Hospital Jakarta In 2021
Authors: Adjie Wilis Laksari Putri , Tidja David Renardo
Published: November 2022

Background : Osteoarthritis (OA) is a degenerative joint disease associated with joint cartilage damage that usually occurs in the aging process. This study is to analyze the correlation between physical activity, body composition, and the micronutrients intake such as vitamin C, D, E, and Calsium the patients with knee OA at the Medical Rehabilitation Clinic (MRC) at Fatmawati Hospital, Jakarta in 2021.Methods: This is a cross sectional quantitative research. The samples were 45 patients who have been diagnosed with knee osteoarthritis in outpatient medical rehabilitation clinic at Fatmawati General Hospital Jakarta who met the inclusion criteria.Results : the results of statistical tests showed that there was a significant difference in the average percentage of body fat with the gradation of OA patients, p value = 0.004. However, there was no significant difference between the average physical activity score, and intake of macronutrients (energy, protein, fat and carbohydrates), BCAAs (arginine and histidine), and intake of micronutrients (vitamin C, vitamin D, vitamin D, vitamin E and Calcium)Conclusion: Percent body fat is the variable with the highest correlation among other factors.
Targeted Neonatal Echocardiography in Patients With Hemodynamic Instability
Authors: Rahde Bischoff Adrianne , Bhombal Shazia , Altman Carolyn A. , Fraga María V. , Punn Rajesh , Rohatgi Ram K. , Lopez Leo , McNamara Patrick J
Published: November 2022

Targeted neonatal echocardiography (TNE) has been increasingly used at the bedside in neonatal care to provide an enhanced understanding of physiology, affecting management in hemodynamically unstable patients. Traditional methods of bedside assessment, including blood pressure, heart rate monitoring, and capillary refill are unable to provide a complete picture of tissue perfusion and oxygenation. TNE allows for precision medicine, providing a tool for identifying pathophysiology and to continually reassess rapid changes in hemodynamics. A relationship with cardiology is integral both in training as well as quality assurance. It is imperative that congenital heart disease is ruled out when utilizing TNE for hemodynamic management, as pathophysiology varies substantially in the assessment and management of patients with congenital heart disease. Utilizing TNE for longitudinal hemodynamic assessment requires extensive training. As the field continues to grow, guidelines and protocols for training and indications are essential for ensuring optimal use and providing a platform for quality assurance.
A new autoimmune disease: atopic dermatitis in children
Authors: Floca Emanuela , Gaga Remus , Sur Genel , Lupan Iulia , Armat Ionel , Gabriel Samasca , Sur Lucia
Published: November 2022

Atopic dermatitis (AD) is mainly considered an allergy, exacerbated by allergic factors. Is there evidence to suggest the existence of autoimmune components in the pathophysiology of the illness? Studies in the literature that dealt with the occurrence of autoimmunity in children with AD were analyzed. We followed the studies published in PubMed for 10 years, from 2001 to 2021. Clinical signs and symptoms were similar to other autoimmune diseases, having periods of remission and relapses. Other correlations between AD and autoimmune diseases have been described, and patients with AD can also present with a wide range of autoimmune comorbidities. Three major factors contribute to the pathogenesis of AD: damage of the skin barrier, disorders of the immune response, and imbalances of the skin microbiome—all based on genetic changes and influenced by environmental factors. Predominant activation of Th 2 cells, with the increase of Th 1, Th 17, and Th 22 subsets, promotes skin inflammation. All this evidence suggests that AD might be classified as an autoimmune disease, not just as an allergic reaction.
Didaktiken efter idealismen
Authors: Bengtsson Stefan
Published: November 2022

Artikelns syfte är att skapa medvetenhet om den tyska idealismens påverkan på didaktiskt tänkande, både när det gäller undervisningsinnehåll och specifikt när undervisningsinnehåll förstås i relation till antropocen. Artikeln är strukturerad så att den belyser de två aspekter som ingår i artikelns titel: kopplingen mellan didaktik och idealism, samt undervisningsobjektets status och antropocen. Den första aspekten rör kopplingen mellan didaktiken och idealismen. Här kommer artikeln påvisa idealismens påverkan på didaktiskt tänkande. Jag argumenterar för att idealismens arv lett till att undervisningsobjektet reduceras till ett undervisningsinnehåll i didaktiskt tänkande. Den andra aspekten rör vikten av att återupptäcka undervisningsinnehållet i antropocen. Det är i relation till antropocen som jag argumenterar för vikten av att göra en åtskillnad mellan undervisningsinnehållet och undervisningsobjektet.