bluuebunny/crossref_metadata_2025 huggingface dataset:
Direct Fiber Simulation of a Compression Molded Ribbed Structure Made of a Sheet Molding Compound with Randomly Oriented Carbon/Epoxy Prepreg Strands—A Comparison of Predicted Fiber Orientations with Computed Tomography Analyses
Authors: Teuwsen Jan , Hohn Stephan K. , Osswald Tim A.
Published: November 2020

Discontinuous fiber composites (DFC) such as carbon fiber sheet molding compounds (CF-SMC) are increasingly used in the automotive industry for manufacturing lightweight parts. Due to the flow conditions during compression molding of complex geometries, a locally varying fiber orientation evolves. Knowing these process-induced fiber orientations is key to a proper part design since the mechanical properties of the final part highly depend on its local microstructure. Local fiber orientations can be measured and analyzed by means of micro-computed tomography (µCT) and digital image processing, or predicted by process simulation. This paper presents a detailed comparison of numerical and experimental analyses of compression molded ribbed hat profile parts made of CF-SMC with 50 mm long randomly oriented strands (ROS) of chopped unidirectional (UD) carbon/epoxy prepreg tape. X-ray µCT scans of three entire CF-SMC parts are analyzed to compare determined orientation tensors with those coming from a direct fiber simulation (DFS) tool featuring a novel strand generation approach, realistically mimicking the initial ROS charge mesostructure. The DFS results show an overall good agreement of predicted local fiber orientations with µCT measurements, and are therefore precious information that can be used in subsequent integrative simulations to determine the part’s mesostructure-related anisotropic behavior under mechanical loads.
Fatigability and Cardiorespiratory Impairments in Parkinson’s Disease: Potential Non-Motor Barriers to Activity Performance
Authors: Pechstein Andrew E. , Gollie Jared M. , Guccione Andrew A.
Published: November 2020

Parkinson’s disease (PD) is the second most common neurodegenerative condition after Alzheimer’s disease, affecting an estimated 160 per 100,000 people 65 years of age or older. Fatigue is a debilitating non-motor symptom frequently reported in PD, often manifesting prior to disease diagnosis, persisting over time, and negatively affecting quality of life. Fatigability, on the other hand, is distinct from fatigue and describes the magnitude or rate of change over time in the performance of activity (i.e., performance fatigability) and sensations regulating the integrity of the performer (i.e., perceived fatigability). While fatigability has been relatively understudied in PD as compared to fatigue, it has been hypothesized that the presence of elevated levels of fatigability in PD results from the interactions of homeostatic, psychological, and central factors. Evidence from exercise studies supports the premise that greater disturbances in metabolic homeostasis may underly elevated levels of fatigability in people with PD when engaging in physical activity. Cardiorespiratory impairments constraining oxygen delivery and utilization may contribute to the metabolic alterations and excessive fatigability experienced in individuals with PD. Cardiorespiratory fitness is often reduced in people with PD, likely due to the combined effects of biological aging and impairments specific to the disease. Decreases in oxygen delivery (e.g., reduced cardiac output and impaired blood pressure responses) and oxygen utilization (e.g., reduced skeletal muscle oxidative capacity) compromise skeletal muscle respiration, forcing increased reliance on anaerobic metabolism. Thus, the assessment of fatigability in people with PD may provide valuable information regarding the functional status of people with PD not obtained with measures of fatigue. Moreover, interventions that target cardiorespiratory fitness may improve fatigability, movement performance, and health outcomes in this patient population.
Mitigation of Channel Shoaling at a Sheltered Inlet Subject to Flood Gate Operations
Authors: Lemke Laura , Janssen Matthew S. , Miller Jon K.
Published: November 2020

A comprehensive case study of Keansburg Inlet (New Jersey, USA) is presented with the objective of evaluating inlet management alternatives and assessing the influence of an operational flood gate on channel shoaling. The goal of the research is determining the most effective strategy for minimizing the frequency of maintenance dredging. This study compares the effectiveness of (1) traditional structural solutions; (2) modified dredging templates; and (3) assesses the influence of the flood gate operations during conditions representative of a typical year. Alternative analysis is completed using a coupled hydrodynamic–wave model (Delft3D-Flexible Mesh (FM)) with Real Time Control to simulate morphological changes. The model was calibrated and evaluated using collected field data. Water levels are reproduced within 6% of the spring tide range with lag times less than 20 min. The model results and observations suggest sediment transport is dominated by wave action with pronounced variations in dominant wave direction. The results indicate that changes to the operational dredging, or what the authors have termed broadly as “adaptive dredging techniques”, appear to deliver the most promising improvement. Model results suggest that the current operational procedures of the flood gate do not significantly alter the channel infilling rates and patterns during typical (i.e., non-extreme event) conditions.
Wave-Current Flow and Vorticity Close to a Fixed Rippled Bed
Authors: Ruggeri Alessia , Musumeci Rosaria Ester , Faraci Carla
Published: November 2020

An experimental study of wave and current interaction over ripples is presented in this paper. The campaign was carried out at the shallow water tank at the Danish Hydraulic Institute (DHI, Denmark), in the framework of the TA WINGS (Waves plus currents INteracting at a right anGle over rough bedS), funded by the European Union (EU) through the Hydralab+ program. Mean velocity profiles, measured with acoustic Doppler velocimeters for different flow conditions including current only, wave only and wave plus current were recorded and allowed to recover flow and vorticity fields. Recirculating cells in both wave only and wave plus current conditions form but they flatten when the current superposes over the wave. It was found that the superposition of current reduces the undertow present in the case of only waves and leads to an increase of vorticity outside the boundary layer. Instead, inside the boundary layer, the vorticity is dumped by the effect of current.
Co-Calibrating Physical and Psychological Outcomes and Consumer Wearable Activity Outcomes in Older Adults: An Evaluation of the coQoL Method
Authors: Manea Vlad , Wac Katarzyna
Published: November 2020

Inactivity, lack of sleep, and poor nutrition predispose individuals to health risks. Patient-Reported Outcomes (PROs) assess physical behaviours and psychological states but are subject of self-reporting biases. Conversely, wearables are an increasingly accurate source of behavioural Technology-Reported Outcomes (TechROs). However, the extent to which PROs and TechROs provide convergent information is unknown. We propose the coQoL PRO-TechRO co-calibration method and report its feasibility, reliability, and human factors influencing data quality. Thirty-nine seniors provided 7.4 ± 4.4 PROs for physical activity (IPAQ), social support (MSPSS), anxiety/depression (GADS), nutrition (PREDIMED, SelfMNA), memory (MFE), sleep (PSQI), Quality of Life (EQ-5D-3L), and 295 ± 238 days of TechROs (Fitbit Charge 2) along two years. We co-calibrated PROs and TechROs by Spearman rank and reported human factors guiding coQoL use. We report high PRO—TechRO correlations (rS ≥ 0.8) for physical activity (moderate domestic activity—light+fair active duration), social support (family help—fair activity), anxiety/depression (numeric score—sleep duration), or sleep (duration to sleep—sleep duration) at various durations (7–120 days). coQoL feasibly co-calibrates constructs within physical behaviours and psychological states in seniors. Our results can inform designs of longitudinal observations and, whenever appropriate, personalized behavioural interventions.
Variant Interpretation in Current Pharmacogenetic Testing
Authors: Luvsantseren Sally , Whirl-Carrillo Michelle , Sangkuhl Katrin , Shin Nancy , Wen Alice , Empey Philip , Alam Benish , David Sean , Dunnenberger Henry M. , Orlando Lori , Altman Russ , Palaniappan Latha
Published: November 2020

In the current marketplace, there are now more than a dozen commercial companies providing pharmacogenetic tests. Each company varies in the panel of genes they test and the variants they are able to screen for. The reports generated by these companies provide phenotypic interpretations of pharmacogenes and clinically actionable gene–drug interactions based on internally curated data and proprietary algorithms. The freedom to choose the types of evidence to include versus exclude in interpreting genomics has created reporting discrepancies in the industry. The case report presented here reveals the discordant phenotype analysis provided by two pharmacogenetic testing companies. The uncertainty and unnecessary distress experienced by the patient highlights the need for consensus in phenotype reporting within the industry.
Temporal Continuities of Grasslands and Forests as Patches of Natural Land in Urban Landscapes: A Case Study of the Tsukuba Science City
Authors: Jingu Shoma
Published: November 2020

Development has fragmented urban nature, and target sites for conservation strategies need to be those that have long maintained their original land cover in a clustered area. Additionally, continuously grasping changes from rural to urban as well as changes over decades after urbanization is essential. Therefore, this study identified and investigated natural patches in urban landscapes, clarified actual management practices in the identified patches, and traced changes in land ownership and land cover during the past 130 years in the Tsukuba Science City, Japan. We first identified areas containing clusters of urban grasslands and forest patches that have existed since the 2010s. We then identified urban green space patches that since the 1880s have remained undeveloped after being agricultural landscapes, despite the rapid urbanization of the Tsukuba Science City since the 1970s. These patches of urban green space were mainly identified near rural communities, research institutions, planned development sites, and golf courses. The findings of this study highlighted the need for new policy implications through systematic arrangement of diverse conservation strategies to maintain urban green space patches. Further investigation is required to elucidate the ecosystem services provided by these remnant green patches.
Gender, Land and Food Access in Ghana’s Suburban Cities: A Case of the Adenta Municipality
Authors: Twum Kwaku Owusu , Asiama Kwabena , Ayer John , Asante Cosmas Yaw
Published: November 2020

The disparity in land and food access in Ghana often overlooks the possibility of an underlying gender disparity. This paper explores and interrogates the disparity between land and food access with respect to gender and the evolution of this relationship over the years as a result of the settlement expansion and urban growth within the Adenta Municipality in Ghana. Adopting a mixed pairwise approach of combining spatial analytical tools, vulnerability indexing and resilient indicators, the paper examines the levels and rates of land accessibilities within the stream of modern cities. It assesses the land market system complexities within developing economies and attempts to address the potential threats of gender-land access gaps. The paper finally assigns weights of ranks to model the phenomenon and recommends trends that can facilitate predictions and early cautionary systems for effective urban land governance in Ghana. The paper concludes that though it is noticed that women engage in power structures on a daily basis, this both benefits and burdens them, depending on their socio-cultural status and other factors in terms of access to land and food.
The Contributions of Crosslinguistic Influence and Individual Differences to Nonnative Speech Perception
Authors: Chang Charles B. , Kwon Sungmi
Published: November 2020

Perception of a nonnative language (L2) is known to be affected by crosslinguistic transfer from a listener’s native language (L1), but the relative importance of L1 transfer vis-a-vis individual learner differences remains unclear. This study explored the hypothesis that the nature of L1 transfer changes as learners gain experience with the L2, such that individual differences are more influential at earlier stages of learning and L1 transfer is more influential at later stages of learning. To test this hypothesis, novice L2 learners of Korean from diverse L1 backgrounds were examined in a pretest-posttest design with respect to their perceptual acquisition of novel L2 consonant contrasts (the three-way Korean laryngeal contrast among lenis, fortis, and aspirated plosives) and vowel contrasts (/o/-/ʌ/, /u/-/ɨ/). Whereas pretest performance showed little evidence of L1 effects, posttest performance showed significant L1 transfer. Furthermore, pretest performance did not predict posttest performance. These findings support the view that L1 knowledge influences L2 perception dynamically, according to the amount of L2 knowledge available to learners at that time. That is, both individual differences and L1 knowledge play a role in L2 perception, but to different degrees over the course of L2 development.
Telomere Instability in Lynch Syndrome Families Leads to Some Shorter Telomeres in MSH2+/- Carriers
Authors: Garrido-Navas M. Carmen , Tippins Frances , Barwell Julian , Hoffman Jonathan , Codd Veryan , Royle Nicola J.
Published: November 2020

Lynch syndrome (LS) is an inherited predisposition to early onset of various cancers, caused by mutation in a DNA mismatch repair (MMR) gene. In heterozygous MMR+/− carriers, somatic mutation, loss or silencing of the wild type allele increases the mutation rate, facilitating the initiation of MMR-defective cancers. These cancers are characterized by instability at short tandem repeats (STRs) and in telomeric DNA. We have investigated telomere length in saliva DNA from LS and control families, using single telomere analysis at XpYp and 12q and by qPCR to measure total telomeric DNA. Single telomere analysis showed a trend for shorter XpYp telomeres in MSH2+/− carriers compared to MLH1+/− carriers or controls, but this was masked in the comparative analysis of total telomeric DNA. Comparison of age-adjusted telomere length within families showed that neither MSH2+/− or MLH1+/− children had consistently shorter or longer telomeres than their MMR+/− parent, indicating the absence of an inter-generational effect on telomere length. Unexpectedly however, wildtype children in families with MSH2 mutations, had significantly longer XpYp telomeres than their MMR+/− parent. Altogether our data suggest that MMR insufficiency, particularly in MSH2+/− carriers, increases telomere instability and somatic cell turnover during the lifetime of LS mutation carriers but has minimal consequences for telomere length in the germline.
Investigation of Genetic Modifiers of Copper Toxicosis in Labrador Retrievers
Authors: Wu Xiaoyan , den Boer Elise R. , Vos-Loohuis Manon , Steenbeek Frank G. van , Monroe Glen R. , Nijman Isaäc J. , Leegwater Peter. A. J. , Fieten Hille
Published: November 2020

Copper toxicosis is a complex genetic disorder in Labrador retrievers characterized by hepatic copper accumulation eventually leading to liver cirrhosis. The variation of hepatic copper levels in Labrador retrievers has been partly explained by mutations in ATP7A c.980C>T and ATP7B c.4358G>A. To further elucidate the genetic background of this disease, we used targeted Next Generation Sequencing (NGS) in a cohort of 95 Labrador retrievers to analyze 72 potential modifier genes for variations associated with hepatic copper levels. Variants associated with copper levels were subsequently evaluated in a replication cohort of 144 Labrador retrievers. A total of 44 variants in 25 different genes were identified, of which four showed significant association with copper levels. Of the four variants found associated with hepatic copper levels in the NGS cohort, one was validated in the replication cohort. The non-reference allele of the variant NC_006602.3.g.52434480C>T in RETN resulting in amino-acid change p.Leu7Phe was associated with decreased hepatic copper levels. In humans, resistin is associated with severity of non-alcoholic fatty liver disease, fibrosis, cirrhosis and mitochondrial dysfunction in hepatocytes. Further studies are needed to investigate the biological function of RETN p.Leu7Phe in the development of copper toxicosis in Labrador retrievers.
Ambulatory Neuroproprioceptive Facilitation and Inhibition Physical Therapy Improves Clinical Outcomes in Multiple Sclerosis and Modulates Serum Level of Neuroactive Steroids: A Two-Arm Parallel-Group Exploratory Trial
Authors: Angelova Gabriela , Skodova Tereza , Prokopiusova Terezie , Markova Magdalena , Hruskova Natalia , Prochazkova Marie , Pavlikova Marketa , Spanhelova Sarka , Stetkarova Ivana , Bicikova Marie , Kolatorova Lucie , Rasova Kamila
Published: November 2020

Background: Only few studies have monitored the potential of physical activity training and physical therapy to modulate the reaction of the endocrine system. In this study, the effect of neuroproprioceptive facilitation and inhibition physical therapy on clinical outcomes and neuroactive steroids production in people with multiple sclerosis was evaluated. Moreover, we were interested in the factors that influence the treatment effect. Methods: In total, 44 patients with multiple sclerosis were randomly divided into two groups. Each group underwent a different kind of two months ambulatory therapy (Motor program activating therapy and Vojta’s reflex locomotion). During the following two months, participants were asked to continue the autotherapy. Primary (serum level of cortisol, cortisone, 7α-OH-DHEA, 7β-OH-DHEA, 7-oxo-DHEA, DHEA) and secondary (balance, cognition and patient-reported outcomes) outcomes were examined three times (pre, post, and washout assessments). Results: In both groups, there is a decreasing trend of 7-oxo-DHEA concentration in post-assessment and 7β-OH-DHEA in washout versus pre-assessment. A higher impact on neuroactive steroids is visible after Vojta’s reflex locomotion. As for clinical outcomes, the Paced Auditory Serial Addition Test and Multiple Sclerosis Impact Scale significantly improved between post-assessment and washout assessment. The improvement was similar for both treatments. Conclusions: Neuroproprioceptive facilitation and inhibition improved the clinical outcomes and led to non-significant changes in neuroactive steroids. Trial registration (NCT04379193).
Environmentally Friendly Polymers and Polymer Composites
Authors: Balart Rafael , Montanes Nestor , Dominici Franco , Boronat Teodomiro , Torres-Giner Sergio
Published: November 2020

In the last decade, continuous research advances have been observed in the field of environmentally friendly polymers and polymer composites due to the dependence of polymers on fossil fuels and the sustainability issues related to plastic wastes. This research activity has become much more intense in the food packaging industry due to the high volume of waste it generates. Biopolymers are nowadays considered as among the most promising materials to solve these environmental problems. However, they still show inferior performance regarding both processability and end-use application. Blending currently represents a very cost-effective strategy to increase the ductility and impact resistance of biopolymers. Furthermore, different lignocellulosic materials are being explored to be used as reinforcing fillers in polymer matrices for improving the overall properties, lower the environmental impact, and also reduce cost. Moreover, the use of vegetable oils, waste derived liquids, and essential oils opens up novel opportunities as natural plasticizers, reactive compatibilizers or even active additives for the development of new polymer formulations with enhanced performance and improved sustainability profile.
Microstructure Evolution of 316L Steel Prepared with the Use of Additive and Conventional Methods and Subjected to Dynamic Loads: A Comparative Study
Authors: Ziętala Michał , Durejko Tomasz , Panowicz Robert , Konarzewski Marcin
Published: November 2020

The mechanical properties and microstructure evolution caused by dynamic loads of 316L stainless steel, fabricated using the Laser Engineered Net Shaping (LENS) technique and hot forging method were studied. Full-density samples, without cracks made of 316L stainless steel alloy powder by using the LENS technique, are characterized by an untypical bi-modal microstructure consisting of macro-grains, which form sub-grains with a similar crystallographic orientation. Wrought stainless steel 316L has an initial equiaxed and one-phase structure, which is formed by austenite grains. The electron backscattered diffraction (EBSD) technique was used to illustrate changes in the microstructure of SS316L after it was subjected to dynamic loads, and it was revealed that for both samples, the grain refinement increases as the deformation rate increases. However, in the case of SS316L samples made by LENS, the share of low-angle boundaries (sub-grains) decreases, and the share of high-angle boundaries (grains of austenite) increases. Dynamically deformed wrought SS316L is characterized by the reverse trend: a decrease in the share of high-angle boundaries and an increase in the share of low-angle boundaries. Moreover, additively manufactured SS316L is characterized by lower plastic flow stresses compared with hot-forged steel, which is caused by the finer microstructure of wrought samples relative to that of additive samples. In the case of additively manufactured 316L steel samples subjected to a dynamic load, plastic deformation occurs predominantly through dislocation slip, in contrast to the wrought samples, in which the dominant mechanism of deformation is twinning, which is favored by a high deformation speed and low stacking fault energy (SFE) for austenite.
Tribological Behavior of AlCrSiN-Coated Tool Steel K340 Versus Popular Tool Steel Grades
Authors: Drozd Kazimierz , Walczak Mariusz , Szala Mirosław , Gancarczyk Kamil
Published: November 2020

The tribological performance of metalwork steel tools is of vital importance in both cold and hot working processes. One solution for improving metal tool life is the application of coatings. This paper investigates the differences in quantitative wear behavior and wear mechanisms between AlCrSiN-coated and bare steel K340 and five reference tool steels: X155CrVMo12-1, X37CrMoV5-1, X40CrMoV5-1, 40CrMnMo7 and 90MnCrV8. The investigated tool steels were heat-treated, while K340 was subjected to thermochemical treatment and then coated with an AlCrSiN hard film (K340/AlCrSiN). The hardness, chemical composition, phase structure and microstructure of steels K340 and K340/AlCrSiN were examined. Tribological tests were conducted using the ball-on-disc tester in compliance with the ASTM G99 standard. The tests were performed under dry unidirectional sliding conditions, using an Al2O3 ball as a counterbody. The wear factor and coefficient of friction were estimated and analyzed with respect to hardness and alloying composition of the materials under study. Scanning electron microscopy (SEM) observations were made to identify the sliding wear mechanisms of the analyzed tool steels and physical vapor deposition (PVD)- coated K340 steel. In contrast to the harsh abrasive–adhesive wear mechanism observed for uncoated tool steels, the abrasive wear dominates in case of the AlCrSiN. The deposited thin film effectively prevents the K340 substrate from harsh wear severe degradation. Moreover, thanks to the deposited coating, the K340/AlCrSiN sample has a coefficient of friction (COF) of 0.529 and a wear factor of K = 5.68 × 10−7 m3 N−1 m−1, while the COF of the reference tool steels ranges from 0.70 to 0.89 and their wear factor ranges from 1.68 × 10−5 to 3.67 × 10−5 m3 N−1 m−1. The AlCrSiN deposition reduces the wear of the K340 steel and improves its sliding properties, which makes it a promising method for prolonging the service life of metalwork tools.
Uncompatibilized PBAT/PLA Blends: Manufacturability, Miscibility and Properties
Authors: Su Shen , Duhme Mona , Kopitzky Rodion
Published: November 2020

Polymer blends of poly(butylene adipate-co-terephthalate) (PBAT) and polylactide (PLA) have been drawn attention due to the application potential as packaging or agricultural films. This study aims to determine the manufacturability, miscibility and mechanical properties of uncompatibilized PBAT/PLA blends prepared using different techniques. First, PBAT and PLA are melt-blended in a wide range of ratios from 90/10 to 10/90. The compounds are then processed into pressed panels, flat films and blown films. Finally, the thermal, morphological, rheological and mechanical properties of these blends are investigated. PBAT/PLA blends have a small difference of solubility parameters, predicting theoretically good miscibility. However, they show two almost unchanged glass transition temperatures in the DSC, phase separation in SEM and two relaxation mechanisms in the Cole–Cole plot. The phase morphology varies depending on both the blend ratios and the preparation techniques. Tensile tests indicate that with increasing PLA content the elongation at break decreases. A good correlation between the elongation at break and the tear propagation resistance is found. Furthermore, the trouser tear method is proven to be more applicable to differentiate highly extensible blown films compared with the Elmendorf tear method.
Prediction of Parameters of Equivalent Sum Rough Surfaces
Authors: Pawlus Pawel , Reizer Rafal , Zelasko Wieslaw
Published: November 2020

In statistical models, the contact of two surfaces is typically replaced by the contact of a smooth, flat, and an equivalent rough sum surface. For the sum surface, the zeroth, second, and fourth moments of the power spectral density m0, m2, and m4 respectively, are the sum of spectral moments of two contacted surfaces. In this work, the selected parameters of the sum surfaces were predicted when the parameters of individual surfaces are known. During parameters selection, it was found that the pair of parameters: Sp/Sz (the emptiness coefficient) and Sq/Sa, better described the shape of the probability ordinate distribution of the analyzed textures than the frequently applied pair: the skewness Ssk and the kurtosis Sku. It was found that the RMS height Sq and the RMS slope Sdq were predicted with very high accuracy. The accuracy of prediction of the average summit curvature Ssc, the areal density of summits Sds, and parameters characterizing the shape of the ordinate distribution Sp/Sz and Sq/Sa was also good (the maximum relative errors were typically smaller than 10%).
Pressure-Dependent Tuning of Photoluminescence and Size Distribution of Carbon Nanodots for Theranostic Anticancer Applications
Authors: Mauro Nicolò , Utzeri Mara Andrea , Buscarino Gianpiero , Sciortino Alice , Messina Fabrizio , Cavallaro Gennara , Giammona Gaetano
Published: November 2020

Carbon nanodots (CDs) have recently attracted attention in the field of nanomedicine because of the biocompatibility, cost-effective nature, high specific surface, good near infrared (NIR) photothermal conversion into heat and tunable fluorescence properties, which have paved the way toward incorporating use of CDs into innovative anticancer theranostic platforms. However, a reliable synthesis of CDs with established and controlled physiochemical proprieties is precluded owing to the lack of full manipulation of thermodynamic parameters during the synthesis, thus limiting their use in real world medical applications. Herein, we developed a robust solvothermal protocol which allow fine controlling of temperature and pressure in order to obtain CDs with tunable properties. We obtained different CDs by modulating the operating pressure (from 8 to 18.5 bar) during the solvothermal decomposition of urea and citric acid in N,N-dimethylformamide at fixed composition. Atomic force microscopy (AFM), Fourier transform infrared (FTIR), ultraviolet-visible (UV-vis) and fluorescence spectroscopy were used to assess the role of pressure in influencing size, optical and surface properties of the obtained CDs. While preliminary biological and anticancer performance of CDs was established on the MDA-MB-231 cell line, used as triple negative breast cancer model. Our results indicate that pressure impinge on the formation of carbon nanoparticles under solvothermal conditions and impart desired optical, size distribution, surface functionalization and anticancer properties in a facile way. However, we have highlighted that a strategic surface engineering of these CDs is needed to limit the adsorption of corona proteins and also to increase the average surface diameter, avoiding a rapid renal clearance and improving their therapeutic efficacy in vivo.
Molecular Fingerprint Imaging to Identify Dental Caries Using Raman Spectroscopy
Authors: Miyamoto Nao , Adachi Tetsuya , Boschetto Francesco , Zanocco Matteo , Yamamoto Toshiro , Marin Elia , Somekawa Shota , Ashida Ryutaro , Zhu Wenliang , Kanamura Narisato , Nishimura Ichiro , Pezzotti Giuseppe
Published: November 2020

Tooth loss impairs mastication, deglutition and esthetics and affects systemic health through nutritional deficiency, weight loss, muscle weakness, delayed wound healing, and bone fragility. Approximately 90% of tooth loss is due to dental caries and periodontal disease. Accordingly, early treatment of dental caries is essential to maintaining quality of life. To date, the clinical diagnosis of dental caries has been based on each dentist’s subjective assessment, but this visual method lacks objectivity. To improve diagnostic ability, highly sensitive quantitative methods have been developed for the diagnosis and prevention of dental caries and are gradually becoming a mandatory item in modern dentistry. High-resolution Raman spectroscopy is a suitable tool for recognizing the subtle structural changes that occur in dental enamel in already developed or, more importantly, incipient dental caries. Raman analysis could soon emerge as a breakthrough in dentistry because of its high diagnostic sensitivity. In this study, we build upon our previous findings in a new analysis of dental caries using Raman spectroscopy imaging and discuss the possibility of using Raman photonic imaging in support of objective diagnostics in dentistry. Our findings support the Raman method of caries detection in comparison with other conventional or new approaches.
Special Issue: Probabilistic Mechanical Fatigue and Fracture of Materials
Authors: Muñiz-Calvente Miguel , Fernández-Canteli Alfonso
Published: November 2020

When designing structural and mechanical components, general structural integrity criteria must be met in order to ensure a valid performance according to its designed function, that is, supporting loads or resisting any kind of action causing stress and strains to the material without catastrophic failure. For these reasons, the development of solutions to manage the test conditions, failure mechanism, damage evolution, component functionalities and loading types should be implemented. The aim of this Special Issue “Probabilistic Mechanical Fatigue and Fracture of Materials” is to contribute to updating current and future state-of-the-art methodologies that promote an objective material characterization and the development of advanced damage models that ensure a feasible transferability from the experimental results to the design of real components. This is imbricated in some probabilistic background related to theoretical and applied fracture and fatigue theories, and advanced numerical models applied to some real application examples.
Low Temperature Sealing of Anodized Aluminum Alloy for Enhancing Corrosion Resistance
Authors: Jo Hyunbin , Lee Soomin , Kim Donghyun , Lee Junghoon
Published: November 2020

Sealing as a post treatment of anodized aluminum is required to enhance the corrosion resistance by filling nanopores, which allow the penetration of corrosive media toward the base aluminum. We designed a mixed sealing solution with nickel acetate and ammonium fluoride by modifying traditional nickel fluoride cold sealing. The concentration of mixed sealing solution affected the reaction rate of sealing and corrosion current density of anodized aluminum alloy. The higher concentration of mixed sealing solution improved the sealing rate, which was represented by a decrease of corrosion current density of anodized aluminum alloy. However, a mixed sealing solution with 2/3 concentration of general nickel fluoride sealing solution operated at room temperature showed the lowest corrosion current density compared to traditional methods (e.g., nickel fluoride cold sealing (NFCS) and nickel acetate hot sealing) and other mixed sealing solutions. Moreover, the mixed sealing solution with 2/3 concentration of general NFCS had a lower risk for over sealing, which increases the corrosion current density by excessive dissolution of anodic oxide. Therefore, the mixed sealing solution with optimized conditions designed in this work possibly provides a new method for enhancing the corrosion resistance of anodized aluminum alloys.
Influence of Co-Sputtered Ag:Al Ultra-Thin Layers in Transparent V2O5/Ag:Al/AZO Hole-Selective Electrodes for Silicon Solar Cells
Authors: Tom Thomas , Ros Eloi , López-Pintó Nicolau , Miguel Asensi José , Andreu Jordi , Bertomeu Joan , Puigdollers Joaquim , Voz Cristobal
Published: November 2020

As optoelectronic devices continue to improve, control over film thickness has become crucial, especially in applications that require ultra-thin films. A variety of undesired effects may arise depending on the specific growth mechanism of each material, for instance a percolation threshold thickness is present in Volmer-Webber growth of materials such as silver. In this paper, we explore the introduction of aluminum in silver films as a mechanism to grow ultrathin metallic films of high transparency and low sheet resistance, suitable for many optoelectronic applications. Furthermore, we implemented such ultra-thin metallic films in Dielectric/Metal/Dielectric (DMD) structures based on Aluminum-doped Zinc Oxide (AZO) as the dielectric with an ultra-thin silver aluminum (Ag:Al) metallic interlayer. The multilayer structures were deposited by magnetron sputtering, which offers an industrial advantage and superior reliability over thermally evaporated DMDs. Finally, we tested the optimized DMD structures as a front contact for n-type silicon solar cells by introducing a hole-selective vanadium pentoxide (V2O5) dielectric layer.
Hybrid Biocomposites Based on Poly(Lactic Acid) and Silica Aerogel for Food Packaging Applications
Authors: Aragón-Gutierrez Alejandro , Arrieta Marina P. , López-González Mar , Fernández-García Marta , López Daniel
Published: November 2020

Bionanocomposites based on poly (lactic acid) (PLA) and silica aerogel (SiA) were developed by means of melt extrusion process. PLA-SiA composite films were plasticized with 15 wt.% of acetyl (tributyl citrate) (ATBC) to facilitate the PLA processability as well as to attain flexible polymeric formulations for films for food packaging purposes. Meanwhile, SiA was added in four different proportions (0.5, 1, 3 and 5 wt.%) to evaluate the ability of SiA to improve the thermal, mechanical, and barrier performance of the bionanocomposites. The mechanical performance, thermal stability as well as the barrier properties against different gases (carbon dioxide, nitrogen, and oxygen) of the bionanocomposites were evaluated. It was observed that the addition of 3 wt.% of SiA to the plasticized PLA-ATBC matrix showed simultaneously an improvement on the thermal stability as well as the mechanical and barrier performance of films. Finally, PLA-SiA film formulations were disintegrated in compost at the lab-scale level. The combination of ATBC and SiA sped up the disintegration of PLA matrix. Thus, the bionanocomposites produced here show great potential as sustainable polymeric formulations with interest in the food packaging sector.
Pyrolysis of Mixed Plastic Waste: I. Kinetic Study
Authors: Dubdub Ibrahim , Al-Yaari Mohammed
Published: November 2020

Plastic wastes have become one of the biggest global environmental issues and thus recycling such massive quantities is targeted. Low-density polyethylene (LDPE), high-density polyethylene (HDPE), polypropylene (PP), and polystyrene (PS) are considered among the main types of plastic wastes. Since pyrolysis is one of the most promising recycling techniques, this work aims to build knowledge on the co-pyrolysis of mixed polymers using two model-fitting (Criado and Coats–Redfern) methods. Seventeen co-pyrolysis tests using a thermogravimetric analyzer (TGA) at 60 K/min for different mixed compositions of LDPE, HDPE, PP, and PS were conducted. It was observed that the pyrolysis of the pure polymer samples occurs at different temperature ranges in the following order: PS < PP < LDPE < HDPE. However, compared to pure polymer samples, the co-pyrolysis of all-polymer mixtures was delayed. In addition, the synergistic effect on the co-pyrolysis of polymer blends was reported. The Master plot of the Criado model was used to determine the most suitable reaction mechanism. Then, the Coats–Redfern model was used to efficiently obtain the kinetic parameters (R2 ≥ 97.83%) and the obtained values of the activation energy of different polymer blends were ranging from 104 to 260 kJ/mol. Furthermore, the most controlling reaction mechanisms were in the following orders: First order reaction (F1), Contracting sphere (R3), and then Contracting cylinder (R2).
Effect of SiC Reinforcement and Its Variation on the Mechanical Characteristics of AZ91 Composites
Authors: Kumar Anil , Kumar Santosh , Mukhopadhyay Nilay Krishna , Yadav Anshul , Winczek Jerzy
Published: November 2020

In this study, the processing of SiC particulate-strengthened magnesium alloy metal matrix composites via vacuum supported inert atmosphere stir casting process is presented. The effects of small variations in the SiC particulate (average size 20 µm) reinforcement in magnesium alloy AZ91 were examined. It was found that with the addition of SiC particulate reinforcement, the hardness improved considerably, while the ultimate tensile and yield strength improved slightly. The density and porosity of the magnesium alloy-based composites increased with the increase in the wt.% of SiC particulates. The tensile and compressive fracture study of the fabricated composites was also performed. The tensile fractures were shown to be mixed-mode fractures (i.e., ductile and cleavage). The fractured surface also disclosed tiny dimples, micro-crack, and cleavage fractures which increases with increasing reinforcement. For the compression fracture, the surface microstructural studies of AZ91 displayed major shear failure and demonstrated the greater shear bands when compared to AZ91/SiC composites, which instead revealed rough fracture surfaces with mixed-mode brittle and shear features.
Coefficient Estimates for Bi-Univalent Functions in Connection with Symmetric Conjugate Points Related to Horadam Polynomial
Authors: Aydoğan S. Melike , Karahüseyin Zeliha
Published: November 2020

In the current study, we construct a new subclass of bi-univalent functions with respect to symmetric conjugate points in the open disc E, described by Horadam polynomials. For this subclass, initial Maclaurin coefficient bounds are acquired. The Fekete–Szegö problem of this subclass is also acquired. Further, some special cases of our results are designated.
Existence of Positive Solutions for a System of Singular Fractional Boundary Value Problems with p-Laplacian Operators
Authors: Alsaedi Ahmed , Luca Rodica , Ahmad Bashir
Published: November 2020

We investigate the existence and multiplicity of positive solutions for a system of Riemann–Liouville fractional differential equations with singular nonnegative nonlinearities and p-Laplacian operators, subject to nonlocal boundary conditions which contain fractional derivatives and Riemann–Stieltjes integrals.
Monad Metrizable Space
Authors: Göçür Orhan
Published: November 2020

Do the topologies of each dimension have to be same and metrizable for metricization of any space? I show that this is not necessary with monad metrizable spaces. For example, a monad metrizable space may have got any indiscrete topologies, discrete topologies, different metric spaces, or any topological spaces in each different dimension. I compute the distance in real space between such topologies. First, the passing points between different topologies is defined and then a monad metric is defined. Then I provide definitions and some properties about monad metrizable spaces and PAS metric spaces. I show that any PAS metric space is also a monad metrizable space. Moreover, some properties and some examples about them are presented.
Modeling and Controlling Epidemic Outbreaks: The Role of Population Size, Model Heterogeneity and Fast Response in the Case of Measles
Authors: Yagci Sokat Kezban , Armbruster Benjamin
Published: November 2020

Modelers typically use detailed simulation models and vary the fraction vaccinated to study outbreak control. However, there is currently no guidance for modelers on how much detail (i.e., heterogeneity) is necessary and how large a population to simulate. We provide theoretical and numerical guidance for those decisions and also analyze the benefit of a faster public health response through a stochastic simulation model in the case of measles in the United States. Theoretically, we prove that the outbreak size converges as the simulation population increases and that the outbreaks are slightly larger with a heterogeneous community structure. We find that the simulated outbreak size is not sensitive to the size of the simulated population beyond a certain size. We also observe that in case of an outbreak, a faster public health response provides benefits similar to increased vaccination. Insights from this study can inform the control and elimination measures of the ongoing coronavirus disease (COVID-19) as measles has shown to have a similar structure to COVID-19.
Parallel Implementations of ARX-Based Block Ciphers on Graphic Processing Units
Authors: An SangWoo , Kim YoungBeom , Kwon Hyeokdong , Seo Hwajeong , Seo Seog Chung
Published: November 2020

With the development of information and communication technology, various types of Internet of Things (IoT) devices have widely been used for convenient services. Many users with their IoT devices request various services to servers. Thus, the amount of users’ personal information that servers need to protect has dramatically increased. To quickly and safely protect users’ personal information, it is necessary to optimize the speed of the encryption process. Since it is difficult to provide the basic services of the server while encrypting a large amount of data in the existing CPU, several parallel optimization methods using Graphics Processing Units (GPUs) have been considered. In this paper, we propose several optimization techniques using GPU for efficient implementation of lightweight block cipher algorithms on the server-side. As the target algorithm, we select high security and light weight (HIGHT), Lightweight Encryption Algorithm (LEA), and revised CHAM, which are Add-Rotate-Xor (ARX)-based block ciphers, because they are used widely on IoT devices. We utilize the features of the counter (CTR) operation mode to reduce unnecessary memory copying and operations in the GPU environment. Besides, we optimize the memory usage by making full use of GPU’s on-chip memory such as registers and shared memory and implement the core function of each target algorithm with inline PTX assembly codes for maximizing the performance. With the application of our optimization methods and handcrafted PTX codes, we achieve excellent encryption throughput of 468, 2593, and 3063 Gbps for HIGHT, LEA, and revised CHAM on RTX 2070 NVIDIA GPU, respectively. In addition, we present optimized implementations of Counter Mode Based Deterministic Random Bit Generator (CTR_DRBG), which is one of the widely used deterministic random bit generators to provide a large amount of random data to the connected IoT devices. We apply several optimization techniques for maximizing the performance of CTR_DRBG, and we achieve 52.2, 24.8, and 34.2 times of performance improvement compared with CTR_DRBG implementation on CPU-side when HIGHT-64/128, LEA-128/128, and CHAM-128/128 are used as underlying block cipher algorithm of CTR_DRBG, respectively.
Improved Oscillation Results for Functional Nonlinear Dynamic Equations of Second Order
Authors: Hassan Taher S. , Sun Yuangong , Menaem Amir Abdel
Published: November 2020

In this paper, the functional dynamic equation of second order is studied on an arbitrary time scale under milder restrictions without the assumed conditions in the recent literature. The Nehari, Hille, and Ohriska type oscillation criteria of the equation are investigated. The presented results confirm that the study of the equation in this formula is superior to other previous studies. Some examples are addressed to demonstrate the finding.
Estimation of Population Prevalence of COVID-19 Using Imperfect Tests
Authors: Hanin Leonid
Published: November 2020

I formulate three basic biomedical/statistical assumptions that should ideally guide well-designed population prevalence studies of the present or past disease including COVID-19. On the basis of these assumptions alone, I compute several probability distributions required for statistical analysis of testing data collected from a sample of individuals drawn from a heterogeneous population. I also construct a consistent asymptotically unbiased estimator of the population prevalence of the disease or infection from the collected data and derive a simple upper bound for its variance. All the results are rigorously proved and valid for any test for COVID-19 or other disease provided that the sum of the test’s sensitivity and specificity is larger than 1. A few recommendations for the design of COVID-19 prevalence studies informed by the results of this work are formulated. The methodology developed in this article may prove applicable to diseases and conditions other than COVID-19 as well as in some non-epidemiological settings.
Non-Parametric Probability Distributions Embedded Inside of a Linear Space Provided with a Quadratic Metric
Authors: Angelini Pierpaolo , Maturo Fabrizio
Published: November 2020

There exist uncertain situations in which a random event is not a measurable set, but it is a point of a linear space inside of which it is possible to study different random quantities characterized by non-parametric probability distributions. We show that if an event is not a measurable set then it is contained in a closed structure which is not a σ-algebra but a linear space over R. We think of probability as being a mass. It is really a mass with respect to problems of statistical sampling. It is a mass with respect to problems of social sciences. In particular, it is a mass with regard to economic situations studied by means of the subjective notion of utility. We are able to decompose a random quantity meant as a geometric entity inside of a metric space. It is also possible to decompose its prevision and variance inside of it. We show a quadratic metric in order to obtain the variance of a random quantity. The origin of the notion of variability is not standardized within this context. It always depends on the state of information and knowledge of an individual. We study different intrinsic properties of non-parametric probability distributions as well as of probabilistic indices summarizing them. We define the notion of α-distance between two non-parametric probability distributions.