bluuebunny/crossref_metadata_2025 huggingface dataset:
Evaluation of 60Co Irradiation on Volatile Components of Turmeric (Curcumae Longae Rhizoma) Volatile Oil with GC–IMS
Authors: He Ye , Yin Lu , Zhou Wei , Wan Hongyan , Lei Chang , Li Shunxiang , Huang Dan
Published: June 2023

60Co irradiation is an efficient and rapid sterilization method. The aim of this work is to determine the changes in essential-oil composition under different irradiation intensities of 60Co and to select an appropriate irradiation dose with GC–IMS. Dosages of 0, 5, and 10 kGy of 60Co were used to analyze turmeric (Curcumae Longae Rhizoma) volatile oil after 60Co irradiation (named JH-1, JH-2, and JH-3). The odor fingerprints of volatile organic compounds in different turmeric volatile oil samples were constructed by headspace solid-phase microextraction and gas chromatography–ion mobility spectrometry (GC–IMS) after irradiation. The differences in odor fingerprints of volatile organic compounds (VOCs) were compared by principal component analysis (PCA). The results showed that 97 volatile components were detected in the volatile oil of Curcuma longa, and 64 components were identified by database retrieval. With the change in irradiation intensity, the volatile compounds in the three turmeric volatile oil samples were similar, but the peak intensity was significantly different, which was attributed to the change in compound composition and content caused by different irradiation doses. In addition, the principal component analysis showed that JH-2 and JH-3 were relatively correlated, while JH-1 and JH-3 were far from each other. In general, different doses of 60Co irradiation can affect the content of volatile substances in turmeric volatile oil. With the increase in irradiation dose, the peak area decreased, and so the irradiation dose of 5 kGy/min was better. It is shown that irradiation technology has good application prospects in the sterilization of foods with volatile components. However, we must pay attention to the changes in radiation dose and chemical composition.
Inhibition of Fungal Growth and Aflatoxin B1 Synthesis in Aspergillus flavus by Plasma-Activated Water
Authors: Yao Qihuan , Xu Hangbo , Zhuang Jie , Cui Dongjie , Ma Ruonan , Jiao Zhen
Published: June 2023

The gaseous reactive oxygen/nitrogen species (RONS) generated by cold atmospheric plasma (CAP) can effectively inactivate Aspergillus flavus (A. flavus) and prolong the shelf-life of food. Plasma-activated water (PAW) is the extension of cold plasma sterilization technology. Without the limitation of a plasma device, PAW can be applied to more scenarios of food decontamination. However, the efficacy of PAW as a carrier of RONS for eradicating A. flavus or inhibiting its growth remains unclear. In this study, the immediate fungicidal effect and long-term inhibitory effect of PAW on A. flavus were investigated. The results demonstrated that 60-min instant-prepared PAW could achieve a 3.22 log reduction CFU/mL of A. flavus and the fungicidal efficacy of PAW gradually declined with the extension of storage time. Peroxynitrite (ONOO−/ONOOH) played a crucial role in this inactivation process, which could damage the cell wall and membrane structure, disrupt intracellular redox homeostasis, and impair mitochondrial function, ultimately leading to fungal inactivation. In addition to the fungicidal effect, PAW also exhibited fungistatic properties and inhibited the synthesis of aflatoxin B1 (AFB1) in A. flavus. By analyzing the cellular antioxidant capacity, energy metabolism, and key gene expression in the AFB1 synthesis pathway, it was discovered that PAW can significantly reduce ATP levels, while increasing SOD and CAT activity during 5-d cultivation. Meanwhile, PAW effectively suppressed the expression of genes related to AFB1 synthesis.
Fractional Modeling and Control of Lightweight 1 DOF Flexible Robots Robust to Sensor Disturbances and Payload Changes
Authors: Benftima Selma , Gharab Saddam , Feliu Batlle Vicente
Published: June 2023

Model design and motion control are considered the cornerstones of the robotic field that allow for achieving performance tasks. This article proposes a new dynamic modeling and control approach for very lightweight mechanical systems carrying payloads. The selection of the model and the design of the control are elaborated on using a fractional order framework under different conditions. The use of fractional order calculus is justified by the better performance that reveals a fractional order model compared to an integer order model of similar complexity. The mechanical structure of very lightweight manipulators has vibrations that impede the accurate positioning of their end effector. Moreover, they have actuators with high friction and sensors to measure the vibrations, which often are strain gauges, that have offset and high-frequency noise. All these mentioned problems might degrade the mechanical system’s performance. Hence, to overcome these inconveniences, two nested-loop controls are examined: an inner loop that controls the motor dynamics and removes the friction effects and an outer loop implemented to eliminate the beam vibrations by adapting the input-state feedback linearization technique. Then, we propose a new fractional order control scheme that (1) removes the strain gauge offset disturbances, (2) reduces the risk of the actuator’s saturation caused by the high-frequency noise of strain gauges and (3) reduces the dynamic effects of huge payload changes. We prove that our fractional controller has enhanced robustness with respect to the above-mentioned problems. Finally, the investigated approach is validated experimentally by applying it to a lightweight robot mounted on an air table.
Genome-Wide Analysis of Sheep Artificially or Naturally Infected with Gastrointestinal Nematodes
Authors: Thorne Jacob W. , Redden Reid , Bowdridge Scott A. , Becker Gabrielle M. , Stegemiller Morgan R. , Murdoch Brenda M.
Published: June 2023

The anthelmintic resistance of gastrointestinal nematodes (GINs) poses a significant threat to sheep worldwide, but genomic selection can serve as an alternative to the use of chemical treatment as a solution for parasitic infection. The objective of this study is to conduct genome-wide association studies (GWASs) to identify single nucleotide polymorphisms (SNPs) in Rambouillet (RA) and Dorper × White Dorper (DWD) lambs associated with the biological response to a GIN infection. All lambs were genotyped with a medium-density genomic panel with 40,598 markers used for analysis. Separate GWASs were conducted using fecal egg counts (FECs) from lambs (<1 year of age) that acquired their artificial infections via an oral inoculation of 10,000 Haemonchus contortus larvae (n = 145) or naturally while grazing on pasture (n = 184). A GWAS was also performed for packed cell volume (PCV) in artificially GIN-challenged lambs. A total of 26 SNPs exceeded significance and 21 SNPs were in or within 20 kb of genes such as SCUBE1, GALNT6, IGF1R, CAPZB and PTK2B. The ontology analysis of candidate genes signifies the importance of immune cell development, mucin production and cellular signaling for coagulation and wound healing following epithelial damage in the abomasal gastric pits via H. contortus during GIN infection in lambs. These results add to a growing body of the literature that promotes the use of genomic selection for increased sheep resistance to GINs.
The Role of PLA2R in Primary Membranous Nephropathy: Do We Still Need a Kidney Biopsy?
Authors: McDonnell Thomas , Wu Henry H. L. , Sinha Smeeta , Chinnadurai Rajkumar
Published: June 2023

Membranous nephropathy (MN) is the most prevalent cause of nephrotic syndrome amongst the non-diabetic adult population. A fifth of idiopathic nephrotic syndrome cases can be attributed to MN, rising to more than 40% in older patients over 60 years. Most MN cases are classified as being of a primary cause, where there is absence of a secondary disease process explaining its manifestation. Traditionally, the standard approach of diagnosing MN involves performing a kidney biopsy as histological evaluation offers not only conclusive evidence of the diagnosis but also provides valuable information regarding disease chronicity and the presence of any other kidney histopathological features. Nevertheless, kidney biopsy is an invasive procedure which poses risks for the patient including bleeding and pain and bears greater costs for the health system. The identification of the phospholipase A2 receptor (PLA2R) antigen in 2009 was a landmark discovery, one which has evolved our understanding of the disease processes in MN and subsequently our management approach of this condition. Antibodies against PLA2R (PLA2RAb) have since emerged as an attractive non-invasive test option to be applied for the diagnosis and prognostication of primary MN. However, much debate and unknowns remain about the accuracy and reliability of testing for PLA2RAb across various primary MN scenarios. We provide a review summarizing the historical journey of PLA2R in relation to its significance in primary MN and, more importantly, evidence emerging over the years which contemplated the role of PLA2RAb as a diagnostic and prognostic tool in primary MN.
SLC5A1 Variants in Turkish Patients with Congenital Glucose-Galactose Malabsorption
Authors: Hoşnut Ferda Ö. , Janecke Andreas R. , Şahin Gülseren , Vogel Georg F. , Lafcı Naz G. , Bichler Paul , Müller Thomas , Huber Lukas A. , Valovka Taras , Aksu Aysel Ü.
Published: June 2023

Congenital glucose-galactose malabsorption is a rare autosomal recessive disorder caused by mutations in SLC5A1 encoding the apical sodium/glucose cotransporter SGLT1. We present clinical and molecular data from eleven affected individuals with congenital glucose-galactose malabsorption from four unrelated, consanguineous Turkish families. Early recognition and timely management by eliminating glucose and galactose from the diet are fundamental for affected individuals to survive and develop normally. We identified novel SLC5A1 missense variants, p.Gly43Arg and p.Ala92Val, which were linked to disease in two families. Stable expression in CaCo-2 cells showed that the p.Ala92Val variant did not reach the plasma membrane, but was retained in the endoplasmic reticulum. The p.Gly43Arg variant, however, displayed processing and plasma membrane localization comparable to wild-type SGLT1. Glycine-43 displays nearly invariant conservation in the relevant structural family of cotransporters and exchangers, and localizes to SGLT1 transmembrane domain TM0. p.Gly43Arg represents the first disease-associated variant in TM0; however, the role of TM0 in the SGLT1 function has not been established. In summary, we are expanding the mutational spectrum of this rare disorder.
The Spaces and Places of the Tourism Encounter. On Re-Centring the Human in a More-Than/Non-Human World
Authors: Huijbens Edward Hákon
Published: June 2023

This paper will revalue the phenomenological understandings of the tourism encounter, inspired by spatial theories of intentionality. With a growing body of theory delving into the relational realm and the ways in which the body and our actions are relationally enmeshed in networks of more-than/non-human entities, this paper seeks to recentre human intentionality as the core of the tourism encounter to better address its political nature and relevance. Whilst thereby critiquing some of the propositions of relational ontology, the paper is not about rejecting these, but augmenting them through a focus on the intention to care. Thereby, the paper will explore the ways in which the tourism encounter can be re-storied as one for making spaces and places of conviviality through people relating to each other and their surroundings with particular intent imbued with care. Valuing care and how it can be narrated helps to make space for a plurality of futures which can in turn break the deadlock of tourism being conceived either as mass/over- or alternative tourism. Both of these and more exist at the same time in the same place.
Effects of the Italian Law on Patient Safety and Health Professional Responsibilities Five Years after Its Approval by the Italian Parliament
Authors: Candido Giuseppe , Cascini Fidelia , Lachman Peter , La Regina Micaela , Parretti Chiara , Valentini Valentina , Tartaglia Riccardo
Published: June 2023

The application of the Italian law No. 24/2017, which focused on patient safety and medical liability, in the Italian National Health Service has been evaluated by a survey conducted five years after the promulgation of the law. The law required the establishment of healthcare risk management and patient safety centers in all Italian regions and the appointment of a Clinical Risk Manager (CRM) in all Italian public and private healthcare facilities. This study demonstrates that five years after the approval of the law, it has not yet been fully implemented. The survey revealed a lack of adequate permanent staff in all the Regional Centers, with two employees on average per Center. Few meetings were held with the Regional Healthcare System decision-makers with less than four meetings per year. This reduces the capacity to carry out functions. In addition, the role of the CRMs is weak in most healthcare facilities. More than 20% of CRMs have other roles in the same organization. Some important tasks have reduced application, e.g., assessment of the inappropriateness risk (reported only by 35.3% of CRM) and use of patient safety indicators for monitoring hospitals (20.6% of CRM). The function of the Regional Centers during the COVID-19 pandemic was limited despite the CRMs being very committed. The CRMs units undertake limited research and have reduced collaboration with citizen associations. Despite most of the CRMs believing that the law has had an important role in improving patient safety, 70% of them identified clinicians’ resistance to change and lack of funding dedicated to implementing the law as the main barriers to the management of risk.
Exploring the Link between Family Health and Health Literacy among College Students: The Mediating Role of Psychological Resilience
Authors: Wang Yan-Yan , Huang Xin-Cheng , Yuan Jie , Wu Yi-Bo
Published: June 2023

Enhancing health literacy is of the utmost importance to enhance the physical and mental well-being of college students. Unfortunately, there has been limited research investigating the means of improving college students’ health literacy through the perspective of families. Family health is an interdisciplinary and complex concept that involves multiple factors, and it provides a holistic perspective on the overall well-being of the family unit. Thus, this study aims to examine the relationship between family health and health literacy and scrutinize the mediating role of psychological resilience. A valid sample of 5473 students was collected from a university in November–December 2022 and was assessed using regression analysis. The findings reveal that family health has a positive association with the health literacy of college students (β = 0.56, p < 0.001), with psychological resilience playing a critical mediating role (β = 0.11, 95% CI: [0.09, 0.13]). Therefore, the family ought to be recognized as a fundamental mechanism to enhance college students’ health literacy. Additionally, it is essential to emphasize the amelioration of psychological distress among college students and enhance their psychological resilience, which will be helpful for their overall health consciousness and proficiency.
Socioeconomic Deprivation and Inequalities in Mental Well-Being during the COVID-19 Pandemic among Adolescents
Authors: Jeriček Klanšček Helena , Furman Lucija
Published: June 2023

The COVID-19 pandemic highlighted the existing inequalities in education and mental health. The aim of this study was to examine socioeconomic disadvantages and mental well-being inequalities among Slovenian adolescents in October 2020. The study used nationally representative data from 3052 adolescents aged 14 and 18 (Mage = 14.4 and 18.4). The WHO-5 Well-Being Index (WHO-5) was used to measure mental well-being and risk for depression. Multinomial logistic regression was used to identify differences in the pattern of associations regarding sociodemographic characteristics and experiences during the pandemic with poor well-being and risk for depression. Our study found that adolescents from socially disadvantaged families faced poorer conditions as regards academic performance, had fewer opportunities to socialise with friends online, and were more likely to feel lonely; they reported lower levels of mental well-being and were at a higher risk for depression. The unemployment of both parents and adolescents’ perceptions of family wealth were found to be the most important predictors of depression risk. In addition, experiencing deprivation and economic hardship during the pandemic was also identified as a significant predictor. The study concludes that social and economic conditions were critical determinants of adolescents’ mental health during the pandemic and that effective intervention is needed to promote their well-being and reduce inequalities.
Cortisol as a Stress Indicator in Fish: Sampling Methods, Analytical Techniques, and Organic Pollutant Exposure Assessments
Authors: Lemos Leila , Angarica Leo , Hauser-Davis Rachel , Quinete Natalia
Published: June 2023

Cortisol is the main glucocorticoid released during stress responses in most fish and has been employed to investigate different stressors, including organic pollutants. This review discusses shifts in cortisol concentrations and examines different matrix sampling methods (invasive vs. minimally or non-invasive) and the main analytical cortisol determination techniques (immunoassays and liquid chromatography-tandem mass spectrometry). Assessments on organic pollutant exposure in fish and associated adverse effects are also discussed. Studies in this regard may aid in identifying organic pollutant toxicological modes of action, mechanistic response, toxicokinetics, and toxicodynamics, as well as pollution sources and associated health risks in fish, ultimately aiding in the development of effective management strategies to mitigate the impacts of organic pollutants on fish populations and their associated ecosystems.
Posterior Urethral Valves, Unilateral Vesicoureteral Reflux, and Renal Dysplasia (VURD) Syndrome: Long-Term Longitudinal Evaluation of the Kidney Function
Authors: Paraboschi Irene , Giannettoni Adele , Mantica Guglielmo , Polymeropoulos Alexios , Mishra Pankaj , Clothier Joanna , Garriboli Massimo
Published: June 2023

The presence of unilateral vesicoureteral reflux (VUR), and renal dysplasia associated with posterior urethral valves (PUV) (VURD syndrome) was believed to represent a pressure-released pop-off mechanism protecting kidney function. We aimed to investigate its role with respect to long-term kidney function in a cross-sectional and longitudinal analysis. We compared the iohexol glomerular filtration rate (GFR) measured at 5 (GFR5) and 10 (GFR10) years of age in children with (Group A) and without (Group B) VURD syndrome, who underwent PUV resection under 2 years of age. VURD syndrome was diagnosed in cases of unilateral loss of kidney function (<15% on nuclear medicine test) associated with ipsilateral grade IV-V VUR. VURD syndrome was diagnosed in 16 (12.8%) out of 125 patients who met the inclusion criteria. While the median GFR5 was similar in the 2 groups [Group A: 87.3 (74.7–101.2) mL/min/1.73 m2 vs. Group B: 99.6 (77–113) mL/min/1.73 m2, p-value: 0.181], the median GFR10 values were significantly lower in children with VURD syndrome [Group A: 75.7 (71.2–85.9) mL/min/1.73 m2 vs. Group B: 95.1 (81.2–114.2) mL/min/1.73 m2, p-value: 0.009]. Similar results were obtained in a longitudinal analysis of the children with GFR measurement available both at 5 and 10 years of age [GFR5 in Group A: 93.1 (76.9–103.5) mL/min/1.73 m2 vs. Group B: 97.5 (80–113) mL/min/1.73 m2, p-value: 0.460; GFR10: Group A: 71.9 (71.9–85.9) mL/min/1.73 m2 vs. Group B: 94.8 (81.5–110.6) mL/min/1.73 m2, p-value: 0.024]. In conclusion, VURD syndrome does not show a protective role in kidney function preservation. On the contrary, it seems to be associated with a deterioration of the kidney function on a long-term follow-up.
The Effects of Internal Governance Factors on Lending Portfolio Composition in Islamic Banks
Authors: Naim Nizar Yousef Ahmed , Abdul Rahman Nora Azureen
Published: June 2023

Recent studies indicate that lending portfoliocomposition in Islamic banks is concentrated towardsdebt-based lending portfolio; however, the ideal lending portfoliocomposition in Islamic banks should be an equity-based lending portfolio. This article explores the effects of the internal governance factors on lending portfolio compositionofIslamic banks in the GCC Region. The internal governance factors investigated are board of directors’ characteristics (size and independence), Shariah supervisory board attributes (size and cross-membership), and ownership structure (family and government). The generalized least squares (GLS) method is used to examine the relationship between the study variables. The results indicate that two characteristics of the board of directors, size and independence, and two attributes of the Shariah supervisory board, Shariah board size and Shariah board cross-membership, have significant effects on lending portfolio composition of Islamic banks in the GCC Region. However, the rest of the internal governance factors have no effects on lending portfolio composition of Islamic banks in the GCC Region. These significant results add new contributions to the literature in the area of internal corporate governance of Islamic banks. The article concludes with suggestions for regulators and policy makers in the GCC Region with regard to the ideal characteristics of the board of directors and the optimal attributes of the Shariah supervisory board in Islamic banks as well as directions for future studies in this area of research.
Quantitative Relations between Morphostructural Similarity Degree and Map Scale Change in Contour Clusters in Multi-Scale Map Space
Authors: Wang Rong , Yan Haowen , Lu Xiaomin
Published: June 2023

This paper aims to propose a new approach to calculate the quantitative relations between morphostructural similarity degree and map scale change in multi-scale contour clusters for automatic contour generalization. Terrain lines were extracted by pre-processing of unclosed contour lines, and an indirect quantitative expression method of morphostructural similarity relation was proposed based on terrain line hierarchical trees. Thirteen groups of multi-scale contour clusters with different drainage areas of loess geomorphy were employed to explore the changing regularity of morphostructural similarity indices with map scale. Finally, the quantitative relations between morphostructural similarity degree and map scale change were calculated using 52 groups of points. The results show that power function is the best fit among the candidate functions, and the quantitative relations between the morphostructural similarity degree and map scale change can be expressed using the same power function, which facilitates the automation of contour generalization.
Interactive Thematic Map as a Means of Documenting and Visualizing Information about Cultural Heritage Objects
Authors: Horbiński Tymoteusz , Smaczyński Maciej
Published: June 2023

Technological progress in recent decades has made it possible to develop the process of documentation and visualization of cultural heritage objects. Despite numerous studies dealing with the documentation of cultural heritage objects, no standardized research methodology has yet been developed in this field. The interest of many specialists from different fields carrying out different work related to the documentation of cultural heritage objects has resulted in a large amount of data, which causes problems in its processing and visualization. As a rule, researchers focus on one method of data collection and, consequently, on one type of data visualization. The documentation of cultural heritage is very important. Therefore, the authors of this article have aimed to develop a methodological data collection process for the documentation and visualization of information about cultural heritage objects. This is particularly important in light of the development of new methods of measuring and inventorying cultural heritage objects, such as laser scanning or low-level aerial photogrammetry. The authors recognize the need to systematize the methodology of collecting and processing data on cultural heritage objects. In addition, it is critical to develop a methodology for visualizing the acquired data using terrestrial laser scanning (TLS) and unmanned aerial vehicle (UAV) technology. One of the most important assumptions of the article is to have universally understandable information about the object. The type of documentation and visualization of information developed in the article will be an interactive thematic map (using Leaflet.js and Three.js). Such a map will allow to collect and visualize all kinds of data, from attribute data to 3D models.
Post-Ischemic Permeability of the Blood–Brain Barrier to Amyloid and Platelets as a Factor in the Maturation of Alzheimer’s Disease-Type Brain Neurodegeneration
Authors: Pluta Ryszard , Miziak Barbara , Czuczwar Stanisław J.
Published: June 2023

The aim of this review is to present evidence of the impact of ischemic changes in the blood–brain barrier on the maturation of post-ischemic brain neurodegeneration with features of Alzheimer’s disease. Understanding the processes involved in the permeability of the post-ischemic blood–brain barrier during recirculation will provide clinically relevant knowledge regarding the neuropathological changes that ultimately lead to dementia of the Alzheimer’s disease type. In this review, we try to distinguish between primary and secondary neuropathological processes during and after ischemia. Therefore, we can observe two hit stages that contribute to Alzheimer’s disease development. The onset of ischemic brain pathology includes primary ischemic neuronal damage and death followed by the ischemic injury of the blood–brain barrier with serum leakage of amyloid into the brain tissue, leading to increased ischemic neuronal susceptibility to amyloid neurotoxicity, culminating in the formation of amyloid plaques and ending in full-blown dementia of the Alzheimer’s disease type.
Age-Based Genomic Screening during Childhood: Ethical and Practical Considerations in Public Health Genomics Implementation
Authors: Milko Laura V. , Berg Jonathan S.
Published: June 2023

Genomic sequencing offers an unprecedented opportunity to detect inherited variants that are implicated in rare Mendelian disorders, yet there are many challenges to overcome before this technology can routinely be applied in the healthy population. The age-based genomic screening (ABGS) approach is a novel alternative to genome-scale sequencing at birth that aims to provide highly actionable genetic information to parents over the course of their child’s routine health care. ABGS utilizes an established metric to identify conditions with high clinical actionability and incorporates information about the age of onset and age of intervention to determine the optimal time to screen for any given condition. Ongoing partnerships with parents and providers are instrumental to the co-creation of educational resources and strategies to address potential implementation barriers. Implementation science frameworks and informative empirical data are used to evaluate strategies to establish this unique clinical application of targeted genomic sequencing. Ultimately, a pilot project conducted in primary care pediatrics clinics will assess patient and implementation outcomes, parent and provider perspectives, and the feasibility of ABGS. A validated, stakeholder-informed, and practical ABGS program will include hundreds of conditions that are actionable during infancy and childhood, setting the stage for a longitudinal implementation that can assess clinical and health economic outcomes.
Association between Serum Irisin and Leptin Levels and Risk of Depressive Symptoms in the Diabetic Elderly Population
Authors: Gorska-Ciebiada Malgorzata , Ciebiada Maciej
Published: June 2023

Background: Adipokines are considered to be involved in the pathogenesis of diabetes and depression. The associations of serum levels of leptin and irisin with depressive symptoms were investigated in elderly patients with type 2 diabetes (T2DM). Methods: 189 elderly diabetics were assessed with the 30-item Geriatric Depression Scale (GDS-30), and 57 patients with depressive symptoms and 132 controls were selected. Blood biochemical parameters, including serum irisin and leptin, were measured. Results: Serum irisin levels were decreased and leptin concentrations were significantly higher in T2DM patients with depressive symptoms compared to controls. In all subjects, the irisin level was inversely correlated with the leptin level and the GDS-30 score, whereas the leptin level was highly correlated with BMI and the GDS-30 score. Higher levels of leptin and lower concentrations of irisin are, among other factors, variables indicative of predictive capacity for depressive symptoms in elderly patients with T2DM. Conclusions: The results indicated that irisin and leptin levels may be used as diagnostic markers of depressive symptoms in diabetic, elderly patients and as potential therapeutic targets for the treatment. Further prospective and more extensive studies are needed to clarify the role of these adipokines in the common pathogenesis of depression and diabetes.
Exploring Autonomic Alterations during Seizures in Temporal Lobe Epilepsy: Insights from a Heart-Rate Variability Analysis
Authors: You Sung-Min , Cho Baek-Hwan , Bae Hyo-Eun , Kim Young-Kyun , Kim Jae-Rim , Park Soo-Ryun , Shon Young-Min , Seo Dae-Won , Kim In-Young
Published: June 2023

Epilepsy’s impact on cardiovascular function and autonomic regulation, including heart-rate variability, is complex and may contribute to sudden unexpected death in epilepsy (SUDEP). Lateralization of autonomic control in the brain remains the subject of debate; nevertheless, ultra-short-term heart-rate variability (HRV) analysis is a useful tool for understanding the pathophysiology of autonomic dysfunction in epilepsy patients. A retrospective study reviewed medical records of patients with temporal lobe epilepsy who underwent presurgical evaluations. Data from 75 patients were analyzed and HRV indices were extracted from electrocardiogram recordings of preictal, ictal, and postictal intervals. Various HRV indices were calculated, including time domain, frequency domain, and nonlinear indices, to assess autonomic function during different seizure intervals. The study found significant differences in HRV indices based on hemispheric laterality, language dominancy, hippocampal atrophy, amygdala enlargement, sustained theta activity, and seizure frequency. HRV indices such as the root mean square of successive differences between heartbeats, pNN50, normalized low-frequency, normalized high-frequency, and the low-frequency/high-frequency ratio exhibited significant differences during the ictal period. Language dominancy, hippocampal atrophy, amygdala enlargement, and sustained theta activity were also found to affect HRV. Seizure frequency was correlated with HRV indices, suggesting a potential relationship with the risk of SUDEP.
Modifiable Pancreatic Ductal Adenocarcinoma (PDAC) Risk Factors
Authors: Michalak Natalia , Małecka-Wojciesko Ewa
Published: June 2023

This study aims to summarize the modifiable risk factors for pancreatic ductal adenocarcinoma (PDAC) that have been known for a long time, as well as information from the most recent reports. As a cancer with a late diagnosis and poor prognosis, accurate analysis of PDAC risk factors is warranted. The incidence of this cancer continues to rise, and the five-year survival rate is the lowest with respect to other tumors. The influence of cigarette smoking, alcohol consumption, and chronic pancreatitis in increasing the risk of pancreatic ductal adenocarcinoma is continually being confirmed. There are also newly emerging reports relating to the impact of lifestyle, including physical activity, the gut and oral microbiome, and hepatotropic viruses. A precise understanding of PDAC risk factors can help to identify groups of high-risk patients, and this may contribute to population awareness and education as well as earlier diagnoses with possible better treatment outcomes.
Early Prediction of Mortality after Birth Asphyxia with the nSOFA
Authors: Dathe Anne-Kathrin , Stein Anja , Bruns Nora , Craciun Elena-Diana , Tuda Laura , Bialas Johanna , Brasseler Maire , Felderhoff-Mueser Ursula , Huening Britta M.
Published: June 2023

(1) Birth asphyxia is a major cause of delivery room resuscitation. Subsequent organ failure and hypoxic–ischemic encephalopathy (HIE) account for 25% of all early postnatal deaths. The neonatal sequential organ failure assessment (nSOFA) considers platelet count and respiratory and cardiovascular dysfunction in neonates with sepsis. To evaluate whether nSOFA is also a useful predictor for in-hospital mortality in neonates (≥36 + 0 weeks of gestation (GA)) following asphyxia with HIE and therapeutic hypothermia (TH), (2) nSOFA was documented at ≤6 h of life. (3) A total of 65 infants fulfilled inclusion criteria for TH. All but one infant received cardiopulmonary resuscitation and/or respiratory support at birth. nSOFA was lower in survivors (median 0 [IQR 0–2]; n = 56, median GA 39 + 3, female n = 28 (50%)) than in non-survivors (median 10 [4–12], p < 0.001; n = 9, median GA 38 + 6, n = 4 (44.4%)). This was also observed for the respiratory (p < 0.001), cardiovascular (p < 0.001), and hematologic sub-scores (p = 0.003). The odds ratio for mortality was 1.6 [95% CI = 1.2–2.1] per one-point increase in nSOFA. The optimal cut-off value of nSOFA to predict mortality was 3.5 (sensitivity 100.0%, specificity 83.9%). (4) Since early accurate prognosis following asphyxia with HIE and TH is essential to guide decision making, nSOFA (≤6 h of life) offers the possibility of identifying infants at risk of mortality.
Hematological Alterations after Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy
Authors: Pintado Maria , Lasa Unzúe Inmaculada , Gómez Sanz Remedios , Diez Alonso Manuel , Ortega Miguel , Álvarez de Mon Melchor , Nevado Losada Emilio , Gutierrez Calvo Alberto
Published: June 2023

Background: Cytoreductive surgery (CRS) and hyperthermic intraperitoneal chemotherapy (HIPEC) have benefits for survival in some cancers with peritoneal metastasis. Hematologic toxicity described rate is 2 to 38%. Methods: Patients admitted to an intensive care unit (ICU) after CRS and HIPEC over 78 months. The data recorded were demographic characteristics, the severity of illness, complete blood samples, the type of cancer and extension, HIPEC drug and temperature, ICU and hospital stay and mortality, bleeding, and the need for transfusion of blood products. Results: Of the 96 patients included, 77.1% presented hematological complications: 8.3% leukopenia (<4000/mm3 leucocytes), 66.7% anemia (hemoglobin < 10 mg/dL), and 22.9% coagulopathy (INR < 1.5, or/and aPTT < 45 s, or/and platelet count < 100,000/mm3, or/and <100 mg/dL of serum fibrinogen). Leukopenia was higher in ovarian cancer or those treated with doxorubicin. Females with anemia, ovarian cancer, and those treated with cisplatin or doxorubicin had longer ICU stays. Bleeding complications were low-corrected in a conservative manner. The median ICU stay was 5 (4.0–5.0) days. The ICU mortality rate was 1.0%. Conclusions: In our study, 77.1% of patients treated with CRS and HIPEC developed hematological complications during the postoperative period; the majority of them were not severe and resolved spontaneously, without an effect on mortality or hospital stay.
From Acute Phase to Long COVID: A Cross-Sectional Study of the Epidemiological Profile and Clinical Evaluation of SARS-CoV-2 Infection in Employees at a Pediatric Hospital
Authors: da Silva Marielen Ribeiro Tavares , Costa Ana Paula , da Luz Amanda Almeida , Pelaio Caio Henrique , Cruz Felipe Baleche , Steil Giovanna Fischer , Giamberardino Heloisa Ihle Garcia , Prando Carolina
Published: June 2023

Background: The coronavirus disease 2019 (COVID-19) pandemic began in Brazil on 26 February 2020. By 6 May 2023, 37.4 million cases had been confirmed, causing 701 thousand deaths in the country. We aimed to describe the epidemiological profile and clinical development of COVID-19 cases among the employees of a health institution, from acute infection to long COVID. Methods: This was a longitudinal study using a retrospective and prospective approach via questionnaires referring to epidemiological investigation, which was the inclusion criteria, and about long-term symptoms. Results: A total of 809 employees were detected with SARS-CoV-2 infection via RT-PCR, 466 of them answered the epidemiological investigation, and 101 completed the Long COVID Symptom Questionnaire. The most commonly affected employees were women (88.6%) working in patient care (68.6%). Headache, myalgia, cough, odynophagia, and runny nose were the most frequent symptoms. Only three employees (0.6%) required hospitalization, while the other employees required outpatient management due to mild symptoms. We identified 19 (4.1%) cases of reinfection, and 42 (41.6%) employees reported long-term symptoms, such as myalgia, dyspnea, and headache. Conclusions: Although most cases were mild with good outcomes, long COVID cases identified are noteworthy, as these symptoms may impact quality of life even months after SARS-CoV-2 infection.
Evaluation of Physiochemical and Biological Properties of Biofunctionalized Mg-Based Implants Obtained via Large-Scale PEO Process for Dentistry Applications
Authors: Radwan-Pragłowska Julia , Janus Łukasz , Galek Tomasz , Szajna Ernest , Sierakowska Aleksandra , Łysiak Karol , Tupaj Mirosław , Bogdał Dariusz
Published: June 2023

An increasing number of tooth replacement procedures ending with implant failure generates a great need for the delivery of novel biomedical solutions with appropriate mechanical characteristics that would mimic natural tissue and undergo biodegradation. This phenomenon constitutes a significant difficulty for scientists, since currently applied biomaterials dedicated for this purpose are based on stainless steel, Ti, and Ti and CoCr alloys. One of the most promising raw materials is magnesium, which has been proven to promote bone regeneration and accelerate the tissue healing process. Nevertheless, its high reactivity with body fluid components is associated with fast and difficult-to-control biocorrosion, which strongly limits the application of Mg implants as medical devices. The achievement of appropriate functionality, both physiochemical and biological, to enable the commercial use of Mg biomaterials is possible only after their superficial modification. Therefore, the obtainment of uniform, reproducible coatings increasing resistance to the aqueous environment of the human body combined with a nanostructured surface that enhances implant–cell behaviors is an extremely important issue. Herein, we present a successful strategy for the modification of Mg implants via the PEO process, resulting in the obtainment of biomaterials with lower corrosion rates and superior biological properties, such as the promotion of extracellular matrix formation and a positive impact on the proliferation of MG-63 cells. The implants were investigated regarding their chemical composition using the FT-IR and XRD methods, which revealed that MgO layer formation, as well as the incorporation of electrolyte components such as fluorine and silica, were responsible for the increased microhardness of the samples. An extensive study of the biomaterials’ morphology confirmed that successful surface modification led to a microporous structure suitable for the attachment and proliferation of cells. The three-layer nature of the newly-formed coatings, typical for PEO modification, was confirmed via cross-section analysis. A biocorrosion and biodegradation study proved that applied modification increased their resistance to body fluids. The cell culture study performed herein confirmed that the correct adjustment of modification parameters results in a lack of cytotoxicity of the magnesium implants, cell proliferation enhancement, and improvement in extracellular matrix formation.
An Impeller Optimization Method for the High Specific Speed Mixed-Flow Reactor Coolant Pump Applied to Marine Nuclear Power
Authors: Fu Qiang , Zhao Yun , Lu Yonggang , Zhao Weiqiang , Zhu Rongsheng
Published: June 2023

The reactor coolant pump (RCP) is the only rotating equipment in the primary circuit system of a nuclear power plant and the “heart” of the nuclear reactor. The L formula is defined, and the L/himp is introduced to study the influence of impeller blade type on the performance of the RCP. Twenty groups of models are designed, the concept of arc height ratio is proposed from the perspective of himp and L, and the distribution of internal entropy production within the impeller of the RCP under different Ls and himps of the impeller blade type is analyzed. The results show that when himp remains un-changed and L increases, the low-pressure area at the inlet of the impeller expands while the high-pressure area at the outlet decreases under the design flow or large flow conditions. The smoother blade profile reduces the occurrence of secondary flow phenomena and makes the RCP pressure distribution more uniform. Under design flow and large flow conditions, smaller L/himp and higher himp lead to higher efficiency and head performance. However, higher efficiency and lower head performance can be achieved under small flow conditions with larger L/himp and lower himp.
Nocturia and Sleep in Parkinson’s Disease
Authors: Diaconu Ştefania , Irincu Laura , Ungureanu Larisa , Țînț Diana , Falup-Pecurariu Cristian
Published: June 2023

Background: Nocturia has a high prevalence in Parkinson’s Disease (PD) and is known to be a bothersome symptom for people with Parkinson’s disease (PwPD). Objective: to characterize nocturia in a sample of PwPD, in relation to sleep, fatigue and other non-motor symptoms (NMS). Methods: we assessed 130 PwPD using a comprehensive battery of scales, which includes the Non-Motor Symptoms Questionnaire (NMSQ), International Parkinson and Movement Disorder Society Non-Motor Rating Scale (MDS-NMS), Parkinson’s Disease Sleep Scale version 2 (PDSS-2), Parkinson’s Disease Questionnaire (PDQ-39), The Overactive Bladder Questionnaire-Short form (OABq-SF), and the Parkinson’s Fatigue Scale (PFS-16). Results: according to the positive answers to the item of the NMSQ related to nocturia, patients were divided into PwPD + nocturia, and PwPD − nocturia. Nocturia was reported by 112 patients (86.15%). Quality of life in PwPD + nocturia was worse than in PwPD − nocturia, according to the PDQ-39 scores (13.32 ± 9.00 vs. 26.29 ± 14.55, p < 0.001). Sleep was significantly disturbed in PwPD + nocturia compared to PwPD − nocturia, according to the total scores of various scales, such as PDSS-2, PFS-16. PwPD who complained of nocturia presented higher scores of several NMS. Conclusions: nocturia has a high prevalence in PwPD and it is associated with impaired sleep, fatigue, and reduced quality of life.
Evaluating the Impact of Smart City Policy on Carbon Emission Efficiency
Authors: Xia Xingneng , Yu Ruoxi , Zhang Sheng
Published: June 2023

Smart city policy (SCP) is crucial to addressing climate change and achieving sustainable urban development with low carbon emissions. The purpose of this paper is to investigate the mechanisms through which smart city policies have an impact on carbon emission efficiency (CEE). In terms of research methodology, we construct a quasi-natural experiment on smart city policies in China and use the time-varying DID approach to study this issue. The DEA method was used to measure the CEE. For the data sample, panel data from 281 cities in China between 2007 and 2020 was used in this study. The findings are as follows: ① SCP has a significant impact on CEE. This conclusion remains valid after introducing parallel trend tests, placebo tests, and other robustness tests. ② The mechanism test result reveals that SCP has a positive impact on urban CEE through three main channels: promoting industrial upgrading, increasing public environmental attention, and enhancing marketization. ③ The analysis of heterogeneity reveals that the impact of SCP on CEE is noticeable in cities that belong to well-developed economic regions with a lower intensity of environmental regulations, higher levels of green finance, and fewer official changes. This research contributes to the existing literature on the environmental assessment of SCP and offers valuable policy insights for cities to tackle climate change and sustainable urban planning.
Acquiring the Dutch Plural in a Bilingual Setting: Investigating the Effects of Language Dominance, Overlap, and Variability
Authors: Keydeniers Darlene , Aalberse Suzanne P. , Andringa Sible , Kuiken Folkert
Published: June 2023

In this study, we aimed to deepen the understanding of the circumstances under which crosslinguistic influence occurs, by focusing on the acquisition of the Dutch plural by two- and three-year old children who attend bilingual Dutch-English daycare. In doing so, we explored the roles of variability, overlap and language dominance as these are all factors that have been linked to the occurrence of crosslinguistic influence in studies on bilingual language acquisition and language contact. We investigated the expectation that young children who are exposed to English might show a stronger preference for -s pluralization in Dutch, because of the partial overlap in Dutch and English pluralization. In total, a group of 95 children that grew up with only Dutch and/or English at home and attended bilingual (Dutch-English) daycare (51 females, 44 males, mean age = 3;6 years) participated in an elicited production task. Results showed that no clear-cut evidence for unidirectional crosslinguistic influence from English to Dutch could be found in the form of -s overgeneralizations. However, we did find evidence for the role of variability in this domain of language, since children made more overgeneralizations when rhyme and sonorancy contradicted. Also, English exposure seemed to facilitate correct production of the -s affix, and children who overgeneralized the -s affix were mostly children that were exposed to the English language at home, suggesting that language dominance does play a role in preference for the -s affix.