bluuebunny/crossref_metadata_2025 huggingface dataset:
Thriving through adversity: The role of passion and emotions in the resilience process
Authors: Paquette Virginie , Vallerand Robert J. , Houlfort Nathalie , Fredrickson Barbara L.
Published: September 2022

Objectives

Two cross‐sectional (Studies 1, N = 283 and 2, N = 275) and one prospective (Study 3, N = 238) studies investigated the role of passion (for academia) and emotions in the process of resilience in the education domain and in life in general.

Method

Participants were examined when facing a stressful situation related to their passion for academia (end‐of‐term exam period and a timed education task).

Results

All three studies showed that harmonious passion, through its positive relationship with positive emotions, was positively associated with high positive outcomes in the education domain (satisfaction with one's studies, subjective and objective performance in one's studies) and in life in general via the subjective evaluation of one's life and general health indicators (subjective vitality and fewer negative physical symptoms). On the other hand, obsessive passion was related to mixed effects on resilience. Specifically, obsessive passion related to low levels of functioning (Studies 1 and 3) and also hindered the positive outcomes (Studies 1–3) through its positive relationships with positive and negative emotions, respectively.

Conclusions

In sum, under stress, harmonious passion facilitates high resilience across life domains, whereas obsessive passion yields low resilience across the life or no resilience at all.
Associations between violence, self‐harm and acute psychiatric service use: Implications for inpatient care
Authors: McIvor Lucy , Payne‐Gill James , Beck Alison
Published: September 2022

Accessible Summary

What is known on the subject?

Service users who behave violently may suffer. This is because violence can lead to unnecessary medication, seclusion on the ward and strained relationships with other people. It can also affect a service user's self‐esteem and lead to feelings of shame.

Service users who behave violently can also make life frightening and unpredictable for members of staff, and other service users on the ward.

It is important to gain a sound understanding of violence in order to help reduce it.

What the paper adds to existing knowledge?

Previous research has shown that having a past history of violence, being admitted to PICU and being admitted to hospital under section is associated with violent behaviour on the ward.

We identified several new factors associated with violent behaviour, such as engaging in self‐harm, being the target of another person's violence and being referred to a Psychiatric Liaison Team.

Implications for practice

For some service users, behaving violently may be a response to previous trauma and an expression of distress.

It is therefore important that mental health nurses are supported by their employers to work with service users in a trauma‐informed manner.

Nurses employed across a range of psychiatric settings could benefit from direct interventions such as comprehensive trauma‐informed care training and psychological debrief spaces, or systemic interventions to address staff shortages and improve ward conditions.

Introduction

Instances of violence in acute psychiatric settings are frequent, can be devastating for service users and staff, and are costly. Such settings would benefit from a greater understanding of violence.

Aim

We analysed the association between current and historical variables and rates of inpatient violence. To address gaps in current research, we included instances of self‐harm and being the target of violence. We also included seldom used service metrics.

Method

Data were extracted on admissions to acute adult wards and PICUs 2017–2020 within South London and Maudsley NHS Foundation Trust. A zero‐inflated negative binomial regression mixed model was used to analyse the impact of variables on rates of violence.

Results

Variables associated with an increased rate of violence were as follows: an increased number of violent incidents in the year before admission, being admitted on MHA section, being admitted to PICU, instances of self‐harm, being the target of violence and referral to a Psychiatric Liaison Team.

Discussion

The novel associations found between enacting violence, self‐harm and being the target of violence indicate trauma‐informed care is crucial to reduce violent presentations of distress.

Implications for practice

System level interventions are crucial to ensure mental health nurses are supported to provide trauma‐informed care.
Genomic evidence reveals intraspecific divergence of the hot‐spring snake (Thermophis baileyi), an endangered reptile endemic to the Qinghai‐Tibet plateau
Authors: Yan Chaochao , Song Meng‐Huan , Jiang Dechun , Ren Jin‐Long , Lv Yunyun , Chang Jiang , Huang Song , Zaher Hussam , Li Jia‐Tang
Published: September 2022

Understanding how and why species evolve requires knowledge on intraspecific divergence. In this study, we examined intraspecific divergence in the endangered hot‐spring snake (Thermophis baileyi), an endemic species on the Qinghai‐Tibet Plateau (QTP). Whole‐genome resequencing of 58 sampled individuals from 15 populations was performed to identify the drivers of intraspecific divergence and explore the potential roles of genes under selection. Our analyses resolved three groups, with major intergroup admixture occurring in regions of group contact. Divergence probably occurred during the Pleistocene as a result of glacial climatic oscillations, Yadong‐Gulu rift, and geothermal fields differentiation, while complex gene flow between group pairs reflected a unique intraspecific divergence pattern on the QTP. Intergroup fixed loci involved selected genes functionally related to divergence and local adaptation, especially adaptation to hot spring microenvironments in different geothermal fields. Analysis of structural variants, genetic diversity, inbreeding, and genetic load indicated that the hot‐spring snake population has declined to a low level with decreased diversity, which is important for the conservation management of this endangered species. Our study demonstrated that the integration of demographic history, gene flow, genomic divergence genes, and other information is necessary to distinguish the evolutionary processes involved in speciation.
Arabidopsis latent virus 1, a comovirus widely spread in Arabidopsis thaliana collections
Authors: Verhoeven Ava , Kloth Karen J. , Kupczok Anne , Oymans Geert H. , Damen Janna , Rijnsburger Karin , Jiang Zhang , Deelen Cas , Sasidharan Rashmi , van Zanten Martijn , van der Vlugt René A. A.
Published: September 2022

Transcriptome studies of Illumina RNA‐Seq datasets of different Arabidopsis thaliana natural accessions and T‐DNA mutants revealed the presence of two virus‐like RNA sequences which showed the typical two‐segmented genome characteristics of a comovirus.

This comovirus did not induce any visible symptoms in infected A. thaliana plants cultivated under standard laboratory conditions. Hence it was named Arabidopsis latent virus 1 (ArLV1). Virus infectivity in A. thaliana plants was confirmed by quantitative reverse transcription polymerase chain reaction, transmission electron microscopy and mechanical inoculation. Arabidopsis latent virus 1 can also mechanically infect Nicotiana benthamiana, causing distinct mosaic symptoms.

A bioinformatics investigation of A. thaliana RNA‐Seq repositories, including nearly 6500 Sequence Read Archives (SRAs) in the NCBI SRA database, revealed the presence of ArLV1 in 25% of all archived natural A. thaliana accessions and in 8.5% of all analyzed SRAs. Arabidopsis latent virus 1 could also be detected in A. thaliana plants collected from the wild.

Arabidopsis latent virus 1 is highly seed‐transmissible with up to 40% incidence on the progeny derived from infected A. thaliana plants. This has probably led to a worldwide distribution in the model plant A. thaliana with as yet unknown effects on plant performance in a substantial number of studies.
Reserve regulation and multidimensional relative poverty of farmers: Evidence from the Panda Nature Reserves in China
Authors: Lin Chao , Gao Lan
Published: September 2022

The accurate evaluation of the relationship between nature reserves and poverty is highly significant for the harmonious coexistence between human and nature. It is widely recognized that the establishment of nature reserves is of great importance to the income poverty of farmers, but less attention has been paid to the impact of different reserves on the multidimensional relative poverty of farmers. Based on the survey data of Panda Nature Reserves in China, we analyze the influence of reserve regulation (or not) and regulation intensity on the multidimensional relative poverty of farmers and its mechanism. Results show that farmers in reserves are more likely to fall into multidimensional relative poverty than those outside the reserves, and there is a U‐shaped relationship between regulation intensity and multidimensional relative poverty. Further, the mechanism analysis show that, on average, the establishment of reserves has no significant impact on farmers' resource utilization capability, but too high or too low regulation intensity will affect farmers' resource utilization capacity, and aggravate their multidimensional relative poverty. The conclusions of this paper are not only conducive to the expansion of theoretical research on regulation and poverty, but also provide policy implications for realizing the coordinated development between biodiversity conservation of nature reserves and rural livelihood.
Technology and manufacturing‐and‐service operations since the Industrial Revolution
Authors: Singhal Kalyan , Singhal Jaya
Published: September 2022

Long‐term vision depends upon history. Without a knowledge of history, both scholars and scholarship are incomplete. In a companion paper (Singhal & Singhal, 2022), we reviewed the history of technology, knowledge, and manufacturing before the Industrial Revolution, which began around 1760. Here, we continue this history from 1760 on.
Promoting electric vehicles: Reducing charging inconvenience and price via station and consumer subsidies
Authors: Shi Lingling , Sethi Suresh P. , Çakanyıldırım Metin
Published: September 2022

Environmental and energy independence concerns lead to government subsidies for electric vehicles (EVs). Operational decisions for a government are (i) to incentivize EV ownership by a direct consumer subsidy, a station subsidy that reduces charging inconvenience, or by both subsidies; and (ii) to minimize subsidy expenditure or to maximize EV adoption level. We model the interactions between the government and the charging supplier as a Stackelberg game and study the optimal structure of subsidies by incorporating charging inconvenience. We prove that this inconvenience is decreasing convex in the number of stations. In the expenditure minimization case, the optimal policy depends on the government adoption target and the charging station construction cost. If the adoption target is below a threshold that depends on the construction cost, the government provides pure consumer subsidy or no subsidy; otherwise, a combination of consumer and station subsidies is optimal. As the construction cost increases, the charger builds fewer stations, regardless of the subsidy type. We establish that expenditure minimization and adoption maximization yield the same subsidy policy if the charging inconvenience is linear. In a real‐life case, we find numerically that a station subsidy alone is optimal if the construction cost is not low but the adoption target is low. Besides, a long driving range reduces the need for subsidies significantly if the construction cost is high, whereas a long charging time necessitates high expenditure allocated mostly to a station subsidy.
Mineral oil interferes with potato virus Y in aphid stylets
Authors: Khelifa Mounia
Published: September 2022

Mineral oils have been used for many decades to control the transmission of plant viruses and their ensuing epidemics. Although it is not clearly defined, the mode of action of these oils has been extensively studied, and effects on the feeding behaviour and orientation of the vector or the transmission of the virus by its vector have often been put forward as possible explanations. This study examines the effect of mineral oil on the interaction between potato virus Y (PVY) and its vector, the green peach aphid Myzus persicae, with particular focus on the transmission organ. A lipophilic staining technique was used to visualize the oil inside the insect's stylets for the first time. Virus binding and localization were also examined in aphid stylets following PVY acquisition. The results indicate that the presence of mineral oil on leaves reduces the likelihood of acquiring the virus. This study verified that this reduced acquisition could be accompanied by a reduction in viral load, as measured by reverse transcription‐quantitative PCR on the stylets. The effect of the oil on virus retention inside the stylets was also measured. The mechanism by which the oil impacts virus acquisition seems to take place in the very early stages of acquisition, well before the virus attaches to the stylets.
Ultrasound, as a hypomethylating agent, remodels DNA methylation and alters mRNA transcription in winter wheat (Triticum aestivum L.) seedlings
Authors: Hidvégi Norbert , Gulyás Andrea , Dobránszki Judit
Published: September 2022

Any treatment that affects seed germination and seedling development is of paramount importance from an agricultural point of view since they are critical prerequisites for successful crop production. In present study, we have examined the after‐effect of ultrasonication (at 30 kHz, 70 W for 5 min) of winter wheat (Triticum aestivum L. cv. SE15) seeds on the early seedling growth and development, and accompanying changes in the DNA methylation and transcriptomic pattern in 7‐day‐old seedlings. We used mRNA‐sequencing and whole genome bisulfite sequencing (WGBS) to identify significantly differentially expressed genes (DEGs), significantly differently methylated regions (DMRs) and genes (DMGs). Ultrasonication of seeds did not alter the germination rate but increased both the length and weight of roots and shoots of 7‐day‐old seedlings significantly by 23%–68% and 16%–28%, respectively. Analyzing the expression intensity of 107,891 genes, significantly differentially expressed sequences related mainly to starch biosynthesis, IAA biosynthesis, photosynthesis and TCA cycle pathways. The same pathways were also affected by DNA‐methylation changes. DNA hypomethylation occurred in the global methylation profile after ultrasound treatment altering the accessibility of some genes for transcription. Transcriptomic changes suggested alterations in the crosstalk between IAA and sucrose signaling, enhancement of growth processes, and increased activity of nuclear transcription factor stimulating the transcription of genes having CCAAT motif in the promoter. In the present first whole genome level study, we have identified seed ultrasonication as a priming technique that can act as a hypomethylating agent and thereby is able to modify the mRNA transcription allowing enhanced seedling growth.
Nativism and Nostalgia in the Netherlands1
Authors: Kešić Josip , Frenkel Sammy C. , Speelman Isabel , Duyvendak Jan Willem
Published: September 2022

This article scrutinizes the employment of temporality in nativist discourse. Looking at nostalgia in the context of contemporary nativism reveals that the operative temporality is not limited to just the past. The perception of “threat,” central to nativism, does not only inform historical claims made by nostalgic nativists, but also refers to the present and to the future in which this threat is to be overcome. After defining nativism, the article focuses on nostalgic invocations of the national past. To what (imagined) times do nativists refer when they speak about the “good old days”? What exactly is perceived as attractive about those days? The next section deals with the dystopian and utopian invocations of the future. As for the empirical scope of this article, we focus on the two most influential representatives of the Dutch radical right: Partij voor de Vrijheid and Forum voor Democratie. We conducted a discourse analysis of textual and verbal material from the period between 2006 and 2021. By analyzing the entanglements of past, present, and the future in nativist discourses, this article seeks to enrich our understanding of the role temporality plays in the dominant debates about national belonging.
The Mexican‐American worker: Assimilation, bias, and discrimination, 1940–2019
Authors: Verdugo Richard R. , Swanson David A.
Published: September 2022

Objective

There are two fundamental arguments about why Mexican Americans have failed to be assimilated. Human capital theorists argue that it is due to their inferior human capital. In contrast, other theorists argue that discrimination is the primary reason. Our proposition is that both arguments are better served if data parse out Mexican immigrants. Failure to do so creates statistical bias regarding the “true” status of Mexican‐American workers and thus the Mexican‐American population.

Method

We estimate an earnings function among three Mexican ancestry groups: Mexican‐American workers, Mexican immigrant workers, and a co‐mingled sample of Mexican‐American and Mexican immigrant workers over the period from 1940 to 2017.

Results

Our findings suggest important differences in the earnings process between Mexican‐American workers and Mexican immigrant workers. Moreover, we also find important differences in discrimination between both groups of workers.

Conclusion

If the focus of future research is the labor market experiences of Mexican Americans, care should be made in parsing out Mexican immigrant workers from their sample; otherwise, results would be biased and conclusions inaccurate.
A Compliant Teleoperation System by Utilizing Haptic Guidance and Series Elastic Actuator-Based Gripper
Authors: Faruk Argin Omer , Kaya Ozan , Yagiz Bayraktaroglu Zeki , Ertugrul Seniz
Published: September 2022

This article introduces a haptic-guided teleoperation framework using a series elastic actuator (SEA)-based compliant gripper. The proposed teleoperation system involves one local haptic device, one layer of virtual reality, and one remote industrial manipulator with a compliant gripper. The overall compliance of the teleoperation is distributed between the software and hardware components of the bilateral loop. On the one hand, the implemented haptic guidance is based on an elementary coupling model uniquely defined and established for all interactions among the user, remote manipulator, and virtual interface. On the other hand, the manipulator operating in the remote environment is equipped with a novel compliant gripper based on series elastic actuators, providing passive compliance at the interactions with the environment. Introducing the gripper into the haptic loop is expected to compensate for disturbances due to inaccurate modeling and/or unmodeled dynamics of the remote environment and external effects. The teleoperation system is implemented for manipulation and tracking tasks and tested with different users. Experimental results show that the haptic guidance and the compliant gripper together significantly improve the teleoperation performances in terms of transparency.
Human TKTL1 implies greater neurogenesis in frontal neocortex of modern humans than Neanderthals
Authors: Pinson Anneline , Xing Lei , Namba Takashi , Kalebic Nereo , Peters Jula , Oegema Christina Eugster , Traikov Sofia , Reppe Katrin , Riesenberg Stephan , Maricic Tomislav , Derihaci Razvan , Wimberger Pauline , Pääbo Svante , Huttner Wieland B.
Published: September 2022

Neanderthal brains were similar in size to those of modern humans. We sought to investigate potential differences in neurogenesis during neocortex development. Modern human transketolase-like 1 (TKTL1) differs from Neanderthal TKTL1 by a lysine-to-arginine amino acid substitution. Using overexpression in developing mouse and ferret neocortex, knockout in fetal human neocortical tissue, and genome-edited cerebral organoids, we found that the modern human variant, hTKTL1, but not the Neanderthal variant, increases the abundance of basal radial glia (bRG) but not that of intermediate progenitors (bIPs). bRG generate more neocortical neurons than bIPs. The hTKTL1 effect requires the pentose phosphate pathway and fatty acid synthesis. Inhibition of these metabolic pathways reduces bRG abundance in fetal human neocortical tissue. Our data suggest that neocortical neurogenesis in modern humans differs from that in Neanderthals.
El Niño frequency threshold controls coastal biotic communities
Authors: Broughton Jack M. , Codding Brian F. , Faith J. Tyler , Mohlenhoff Kathryn A. , Gruhn Ruth , Brenner-Coltrain Joan , Hart Isaac A.
Published: September 2022

El Niño has profound influences on ecosystem dynamics. However, we know little about how it shapes vertebrate faunal community composition over centennial time scales, and this limits our ability to forecast change under projections of future El Niño events. On the basis of correlations between geological records of past El Niño frequency and the species composition of bird and fish remains from a Baja California bone deposit that spans the past 12,000 years, we documented marked faunal restructuring when major El Niño events occurred more than five times per century. This tipping point has implications for the past and future ecology of eastern Pacific coastal environments.
Hydroformylation catalyzed by unmodified cobalt carbonyl under mild conditions
Authors: Zhang Baoxin , Kubis Christoph , Franke Robert
Published: September 2022

Hydroformylation with unmodified cobalt carbonyl catalyst plays a crucial role in industrial production of surfactants and plasticizers. However, syngas pressures of 100 to 400 bar with reaction temperatures of 100° to 250°C are typically applied. We report here that unmodified cobalt carbonyl is a stable hydroformylation catalyst at 140°C under 30 bar of syngas. The activity was comparable to that of recently reported bisphosphine-coordinated cobalt(II) catalysts, which we could not reproduce under the reported conditions. Kinetic and in situ infrared spectroscopic studies confirmed the stability of the unmodified cobalt tetracarbonyl hydride [HCo(CO)
4
]. Branched internal olefins were converted to aldehydes with high regioselectivity under low syngas pressures without phosphorus ligands. Bisphosphines had a small promotional effect on the catalyst at phosphorus-to-cobalt loading ratios below 0.6.
Controlling the nucleation and growth kinetics of lead halide perovskite quantum dots
Authors: Akkerman Quinten A. , Nguyen Tan P. T. , Boehme Simon C. , Montanarella Federico , Dirin Dmitry N. , Wechsler Philipp , Beiglböck Finn , Rainò Gabriele , Erni Rolf , Katan Claudine , Even Jacky , Kovalenko Maksym V.
Published: September 2022

Colloidal lead halide perovskite nanocrystals are of interest as photoluminescent quantum dots (QDs) whose properties depend on the size and shape. They are normally synthesized on subsecond time scales through hard-to-control ionic metathesis reactions. We report a room-temperature synthesis of monodisperse, isolable, spheroidal APbBr
3
QDs (“A” indicates cesium, formamidinium, and methylammonium) that are size tunable from 3 to >13 nanometers. The kinetics of both nucleation and growth are temporally separated and substantially slowed down by the intricate equilibrium between the precursor (PbBr
2
) and the A[PbBr
3
] solute, with the latter serving as a monomer. QDs of all these compositions exhibit up to four excitonic transitions in their linear absorption spectra, and we demonstrate that the size-dependent confinement energy for all transitions is independent of the A-site cation.
Longitudinal Evolution of the Pseudomonas-Derived Cephalosporinase (PDC) Structure and Activity in a Cystic Fibrosis Patient Treated with β-Lactams
Authors: Colque Claudia A. , albarracín Orio Andrea G. , Tomatis Pablo E. , Dotta Gina , Moreno Diego M. , Hedemann Laura G. , Hickman Rachel A. , Sommer Lea M. , Feliziani Sofía , Moyano Alejandro J. , Bonomo Robert A. , K. Johansen Helle , Molin Søren , Vila Alejandro J. , Smania Andrea M.
Published: September 2022

Antibiotics are becoming increasingly ineffective to treat bacterial infections. It has been consequently predicted that infectious diseases will become the biggest challenge to human health in the near future.
Pseudomonas aeruginosa
is considered a paradigm in antimicrobial resistance as it exploits intrinsic and acquired resistance mechanisms to resist virtually all antibiotics known.
Genetic Diversity of Fowlpox Virus and Putative Genes Involved in Its Pathogenicity
Authors: Kim Hye-Ryoung , Jang Il , Song Hye-Soon , Kim Si-Hyeon , Kim Hyeon-Su , Kwon Yong-Kuk
Published: September 2022

This study aims at determining molecular candidates using comparative genomics to differentiate between the diphtheritic and cutaneous forms of FPV infection, in addition to their association with the pathogenicity of the virus. Full-genomic analyses of multiple fowlpox strains, including field viruses, isolated between 1960s and 2019, and vaccine strains showed the genetic diversity due to regional differences.
SARS-CoV-2 Variant Delta Potently Suppresses Innate Immune Response and Evades Interferon-Activated Antiviral Responses in Human Colon Epithelial Cells
Authors: Tandel Dixit , Sah Vishal , Singh Nitesh Kumar , Potharaju Poojitha Sai , Gupta Divya , Shrivastava Sauhard , Sowpati Divya Tej , Harshan Krishnan H.
Published: September 2022

Viruses generally learn to coexist with the host during the process of evolution. It is expected that SARS-CoV-2 would also evolve to coexist in humans by trading off its virulence for longer persistence, causing milder disease.
Erratum to: Evoked Potentials of the Midbrain Associated with the Beginning and End of a Sound of a Simple Tone
Authors: Kantserova A. O. , Oknina L. B. , Pitskhelauri D. I. , Podlepich V. V. , Masherov E. L. , Vologdina Y. O.
Published: September 2022

An Erratum to this paper has been published: https://doi.org/10.1134/S0362119722440025
Unilateral, permanent hearing loss following severe COVID-19 infection
Authors: Akbar Sarah , Gopikrishna Darmeena , Leong Weii Jsim
Published: September 2022

Hearing loss following COVID-19 infection has been scarcely reported in the literature.

A previously well middle-aged man presented to the emergency department with breathlessness and cough 8 days after testing positive for COVID-19 in the community. The patient was treated in the intensive care unit due to respiratory failure. Following extubation and step down to ward-level care 2 months later, the patient reported sudden left-sided hearing loss and tinnitus. Ear examination was unremarkable and pure tone audiometry revealed profound left sensorineural hearing loss. MRI of the internal acoustic meatus did not show any cerebellopontine lesions. Intravenous steroid therapy as well as oral steroids were not successful in improvement of hearing.

A few cases of COVID-19-associated sensorineural hearing loss have been reported; the majority report irreversible loss. Awareness of this phenomenon and early referral for specialist review and audiological assessment to attempt salvage of hearing can reduce hearing disability.
Modern endovascular management of chronic total carotid artery occlusion: technical results and procedural challenges
Authors: Radu Răzvan Alexandru , Cagnazzo Federico , Derraz Imad , Dargazanli Cyril , Rapido Francesca , Lefevre Pierre-Henri , Gascou Grégory , Costalat Vincent
Published: September 2022

Background

The optimal management of chronic total carotid artery occlusion (CTO) is still debated. Endovascular treatment is being increasingly used with heterogeneous technical and clinical results.

Methods

Patients with CTO treated with modern endovascular approaches during the past several years (January 2018–December 2021) were retrospectively reviewed.

Results

Twenty patients, with a mean age of 63.7 years, were treated during the study period. Indications for treatment were recurrent stroke in 12 (60%), hemodynamic impairment in 4 (20%), and progressive stroke in 4 (20%) patients. In 6 (30%) patients, the occlusion was limited to the cervical portion, in 5 (25%) to the petrous segment, and in 9 (45%) to the cavernous segment. Technical treatment success was achieved in 80% of cases. In patients with successful recanalization, median pretreatment hypoperfusion volumes dropped from 126 mL (25–75 IQR, 33–224 mL) to 0 mL (25–75 IQR, 0–31.5 mL). Symptomatic procedure-related complications were 30% and permanent procedure-related morbidity-mortality was 5%. Early stent occlusion occurred in 5 (25%) cases. Two cases were asymptomatic and were not retreated, 3 cases presented transient symptoms of which two were successfully recanalized. Stent occlusion was not associated with permanent symptoms. In successfully recanalized patients no intraprocedural emboli were observed.

Conclusions

In the modern endovascular era, revascularization of CTO is a feasible procedure in most cases, and it may be offered in selected patients. However, the high re-occlusion rate is still a limitation of the technique, underlining the need for more research on the technical procedural and periprocedural management.
Freshwater fisheries monitoring in northern ecosystems using Indigenous ecological knowledge, genomics, and life history: Insights for community decision-making
Authors: Bowles Ella , Jeon Hyung-Bae , Marin Kia , MacLeod Pamela , Fraser Dylan J.
Published: September 2022

Natural resources in northern regions are often data-limited because they are difficult and expensive to access. Indigenous ecological knowledge (IEK) can provide information similar to, different from, or complementary to Western scientific data (WSD). We evaluated the general hypothesis that congruence in outcomes of IEK and WSD for population monitoring parameters is determined by temporal and spatial scale of the knowledge type. Parameters included population structure, degree of philopatry, morphological variation (and conservation status for one species), and genomics was a key Western scientific method. We evaluated this hypothesis in three subsistence and recreational fisheries (walleye, lake trout, and northern pike) in Mistassini Lake, Quebec, Canada. Concordance of outcomes was varied. IEK provided richer information on the biology, distribution, and morphological variation observable with the eyes. However, IEK cannot “see” into the genome, and WSD identified population structure and history more precisely than IEK. Both knowledge types could “see” change in populations, and the nature of what was seen both converged and was complementary. Determining when IEK and WSD are complementary or reach common conclusions may allow Indigenous communities to use both together, or one knowledge type over another when either is more desired, appropriate, or time- or cost-efficient to adopt.
Fully heavy dibaryons
Authors: Huang Hongxia , Ping Jialun , Zhu Xinmei , Wang Fan
Published: September 2022

The existence of fully heavy dibaryons $$\varOmega _{ccc}\varOmega _{bbb}$$

Ω

ccc

Ω

bbb

, $$\varOmega _{ccb}\varOmega _{bbc}$$

Ω

ccb

Ω

bbc

, $$\varOmega _{ccc}\varOmega _{ccc}$$

Ω

ccc

Ω

ccc

, and $$\varOmega _{bbb}\varOmega _{bbb}$$

Ω

bbb

Ω

bbb

with $$J=0,~1,~2,~3$$

J
=
0
,

1
,

2
,

3

and $$P=\pm 1$$

P
=
±
1

are investigated in the framework of a constituent quark model with the help of the resonating group method. The dibaryon composed of six c or b quarks with $$J^{P}=0^{+}$$

J
P

=

0
+

is able to be bound, because the requirement for antisymmetrization between the same baryon clusters introduces an attractive interaction between two fully heavy baryons. Although it is difficult for the dibaryon with the color-singlet type $$\varOmega _{ccc}\varOmega _{bbb}$$

Ω

ccc

Ω

bbb

to form any bound state, it is possible for the $$\varOmega _{ccb}\varOmega _{bbc}$$

Ω

ccb

Ω

bbc

state to be bound. The channel coupling of all channels of both $$\varOmega _{ccb}\varOmega _{bbc}$$

Ω

ccb

Ω

bbc

and $$\varOmega _{ccc}\varOmega _{bbb}$$

Ω

ccc

Ω

bbb

structures leads to the bound conclusion of this fully heavy system composed of three c quarks and three b quarks.
Understanding urban bus travel time: Statistical analysis and a deep learning prediction
Authors: Liu Yanjun , Zhang Hui , Jia Jianmin , Shi Baiying , Wang Wei
Published: September 2022

Travel time reliability plays a key role in bus scheduling and service quality. Owing to various stochastic factors, buses often suffer from traffic congestion, delay and bunching, which leads to disturbances of travel time. Automatic vehicle location (AVL) could record the spatiotemporal information of buses, making it possible to understand the status of bus service. In this paper, we specifically analyze the statistical characteristics of travel time based on historic AVL data. Moreover, a Kalman filter-LSTM deep learning is proposed to estimate bus travel time. Numerical tests indicate that the travel time of bus routes shows a left-skewed and right-tail pattern with a good fit of the lognormal distribution. The bus service reliability fluctuates largely in the peak hours, especially the morning peak. Bus bunching and large bus time headway easily occur, and once it occurs, it will continue until destination. The Kalman filter-LSTM model outperforms the ensemble learning methods to predict travel time. This study could provide implications for transit schedule optimization to improve the bus service quality.
Regulation of Host-Pathogen Interactions via the Ubiquitin System
Authors: Mukherjee Rukmini , Dikic Ivan
Published: September 2022

Ubiquitination is a posttranslational modification that regulates a multitude of cellular functions. Pathogens, such as bacteria and viruses, have evolved sophisticated mechanisms that evade or counteract ubiquitin-dependent host responses, or even exploit the ubiquitin system to their own advantage. This is largely done by numerous pathogen virulence factors that encode E3 ligases and deubiquitinases, which are often used as weapons in pathogen–host cell interactions. Moreover, upon pathogen attack, host cellular signaling networks undergo major ubiquitin-dependent changes to protect the host cell, including coordination of innate immunity, remodeling of cellular organelles, reorganization of the cytoskeleton, and reprogramming of metabolic pathways to restrict growth of the pathogen. Here we provide mechanistic insights into ubiquitin regulation of host-pathogen interactions and how it affects bacterial and viral pathogenesis and the organization and response of the host cell.
Rapid and Local EIS on a Segmented Fuel Cell: A New Method for Spatial and Temporal Resolution
Authors: Schmitt Tobias , Bligny Rémi , Maranzana Gaël , Sauter Ulrich
Published: September 2022

A new method for acquiring sub-second electrochemical impedance spectroscopy (EIS) on a segmented proton exchange membrane fuel cell (PEMFC) is applied. High temporally and spatially resolved characterization is obtained through frequency range optimization and imposition of multiple frequencies within one measurement task when characterizing all segments simultaneously. Furthermore, acquisition and postprocessing steps, were decoupled. Spatial and temporal evolution of the transmission line model’s (TLM) parameters are characterized such as membrane resistance

R

m
e
m

as function of operational parameters. The temporal evolution of local and differences to global values are monitored. The transient behavior of re-humidification and stoichiometry variation on membrane resistance are elucidated. Insights in local and global changes and their frequency dependency of membrane resistances addressed to provide a generic guidance for segmented EIS characterization.
Tuning the Tin Oxide-Carbon Composite Support to Deposit Rh Nanoparticles for Glycerol-to-Carbonate Electro-Conversion
Authors: Moreira Thamyres F. M. , Bresciani Guilherme B. , Kokoh K. Boniface , Napporn Teko W. , Olivi Paulo , Morais Claúdia
Published: September 2022

Glycerol Electrooxidation Reaction (GEOR) has been herein investigated on Rh/C and Rh/SnO2-C prepared by polyol method. The particle mean sizes were found to be 2.0 and 1.8 nm in Rh/C and Rh/SnO2-C, respectively. The alloying degree reached 63% in Rh/SnO2-C, confirming a Sn-Rh alloy formation. The activity towards GEOR on Rh/SnO2-C was almost 5-fold higher than on Rh/C, as demonstrated by electrochemical measurements in alkaline medium. This trend indicated the beneficial effect of the SnO2-C carbon-oxide composite support in the catalyst composition. Analysis of the products generated after the bulk electrolysis using high-performance liquid chromatography (HPLC) and FTIRS demonstrated that at 0.55 V vs RHE the main reaction products were glycerate ion and carbonate (CO3
2−). Then, a C–C–C cleavage was demonstrated with the CO3
2− formation at low potentials. During the testings conducted in a home-made acrylic direct glycerol fuel cell at room temperature in 0.5 mol l−1 NaOH, the maximum power density (390 μW cm−2) obtained on a Rh/SnO2 anode, was 5-fold higher than that on Pd/C. These testings demonstrated that the co-generation of sustainable energy and value-added products is a promising way to valorize glycerol.
Mispositioned Hydrus Microstents: A Case Series Imaged with NIDEK GS-1 Gonioscope
Authors: Laroche Daniel , Martin Alexander , Brown Aaron , Sakkari Sohail , Ng Chester
Published: September 2022

Introduction. The Hydrus microstent has become a common procedure in glaucoma surgery intended to improve outcomes of cataract surgery to lower intraocular pressure. Despite proper placement, this device can subsequently be noted to not be in the proper position. In this case series, we report mispositioned Hydrus microstents in five different patients and use NIDEK GS-1 gonioscopy. Case Report. We report five different patients who had cataract surgery and who were subsequently noted to have mispositioned Hydrus stents. No stents needed to be removed. All patients had improved vision and stable visual fields, and none required secondary surgery. Management and Outcome. In each case of mispositioned stents, vision was significantly improved and there was no inflammation or other complications noted. Discussion. Hydrus stents can be noted to be mispositioned during the post-operative period after successful insertion. This can often be well tolerated requiring no further intervention.
Property Characterization of Anti-Aging Additives and Modified Asphalt Based on Long-Term Aging Behavior
Authors: Liu Junlong , Chu Lijing , Zhao Tianyuan , Zhu Yunchu , Cang Zhi , Chen Qian , Yuan Junshen
Published: September 2022

In order to achieve the good application of hindered amine light stabilizer (HALS) in the long-term aging control of asphalt pavement material, Tinuvin770 and Tinuvin622 light stabilizers were selected as modifiers for asphalt. The microstructure and characteristics of hindered amine light stabilizers were characterized by FIB-SEM. The elemental composition and relative content of hindered amine light stabilizers were studied by means of EDS analysis. The functional group composition of hindered amine light stabilizers was analyzed based on Dynamic-FTIR. On this basis, light stabilizer modified asphalt was prepared, and the effect of hindered amine light stabilizer on the thermal rheological properties of asphalt binder during UV aging period was studied by dynamic shear rheology (DSR). The changing law of low temperature rheological properties of hindered amine light stabilizer modified asphalt was evaluated by low temperature bending beam rheological test (BBR). The results showed that the hindered amine light stabilizer could capture the free radicals formed during the photodegradation of asphalt when subjected to ultraviolet aging. Under the impact of ultraviolet aging, hindered amine light stabilizer could improve the high temperature performance of asphalt binder. Furthermore, HALS could achieve the improving effect on the low temperature rheological properties and long-term aging performance of asphalt pavement materials.
Role of Iron-Related Oxidative Stress and Mitochondrial Dysfunction in Cardiovascular Diseases
Authors: Yan Fang , Li Kaifeng , Xing Wenjuan , Dong Mingqing , Yi Mingliang , Zhang Haifeng
Published: September 2022

Iron is indispensable in numerous biologic processes, but abnormal iron regulation and accumulation is related to pathological processes in cardiovascular diseases. However, the underlying mechanisms still need to be further explored. Iron plays a key role in metal-catalyzed oxidative reactions that generate reactive oxygen species (ROS), which can cause oxidative stress. As the center for oxygen and iron utilization, mitochondria are vulnerable to damage from iron-induced oxidative stress and participate in processes involved in iron-related damage in cardiovascular disease, although the mechanism remains unclear. In this review, the pathological roles of iron-related oxidative stress in cardiovascular diseases are summarized, and the potential effects and mechanisms of mitochondrial iron homeostasis and dysfunction in these diseases are especially highlighted.
[Retracted] CYP1B1 Gene Polymorphism Based on Health Monitoring and Nursing Methods after Minimally Invasive Surgery for Lung Cancer
Authors: Liu Chunyan , Liu Bo , Han Xia , Zhang Yanfen
Published: September 2022

The rapid development of science and technology has become an indispensable part of human life. Minimally invasive lung cancer surgery, that is, thoracoscopic surgery and da Vinci robotic surgery, has many advantages over previous surgeries, there is no need to make a large incision in the chest, the patient after such surgery, and recovery is also better and can also reduce the incision of the operation. Therefore, with the rapid development of science and technology today, how to detect changes in patients’ health and establish an intelligent health monitoring system has become a development trend. This paper proposes to apply health monitoring in CYP1B1 gene polymorphism and nursing after clinical treatment of minimally invasive lung cancer surgery, after analyzing the society’s demand for real‐time health monitoring in this paper. It also studies the health monitoring system based on the advantages of smart phones. The system is suitable for the Android operating system and can monitor the temperature, weight, and other data of the human body. The experimental results show that the data value of the information displayed by the android software has a high degree of matching with the measured value, which basically keeps floating around 80, and the data consistency is strong.
Modeling and Performance Analysis of ECS-HTCARQ Protocol in Interference Scenario
Authors: Zhou Yongqiang , Wang Qihao , Song Zhenggang , Li Suoping , Yang Nana
Published: September 2022

To extend the lifetime of energy-constrained wireless networks, this paper proposes a three-node model of the wireless-powered cooperative communication network (WPCCN). The model consists of an energy-constrained source node, an energy-sufficient relay node, and a destination node and considers two different cochannel interference (CCI) sources at the relay and destination nodes. To ensure the reliability of data transmission, we introduce the cooperative automatic retransmission request (CARQ) protocol, propose the energy-constrained source that harvests and cooperates automatic retransmission request (ECS-HTCARQ) protocol in interference scenario, derive a closed-form expression for the outage probability under Rayleigh fading channels, and establish a discrete-time Markov chain (DTMC) model to analyze the system throughput. The relationship between parameters such as the energy harvesting time allocation factor and energy harvesting efficiency on the outage probability and the system throughput is obtained. Numerical results show that the difference in system throughput is small as the increasing number of transmissions at a high signal-to-interference ratio (SIR), but there is a significant reduction in the outage probability. Finally, the optimal value of the energy harvesting time allocation factor is given under this model.
CCL-2 and CXCL-8: Potential Prognostic Biomarkers of Acute Kidney Injury after a Bothrops atrox Snakebite
Authors: Neves Juliana Costa Ferreira , Ibiapina Hiochelson Najibe Santos , Magalhães-Gama Fábio , Sachett Jacqueline Almeida Gonçalves , Silva Iran Mendonça , Coelho Kerolaine Fonseca , Alves Eliane Campos , Tarragô Andréa Monteiro , de Lima Ferreira Luiz Carlos , Malheiro Adriana , Monteiro Wuelton Marcelo , Costa Allyson Guimarães
Published: September 2022

In the Brazilian Amazon, the snake Bothrops atrox is the primary cause of snakebites. B. atrox (BaV) venom can cause systemic pathophysiological changes such as acute kidney injury (AKI), which leads to the production of chemokines and cytokines in response to the envenomation. These soluble immunological molecules act by modulating the inflammatory response; however, the mechanisms associated with the development of AKI are still poorly understood. Here, we characterize the profile of these soluble immunological molecules as possible predictive biomarkers of the development of AKI. The study involved 34 patients who had been victims of snakebites by Bothrops sp. These were categorized into two groups according to the development of AKI (AKI(-)/AKI(+)), using healthy donors as the control (HD). Peripheral blood samples were collected at three-time points: before antivenom administration (T0) and at 24 and 48 hours after antivenom (T1 and T2, respectively). The soluble immunological molecules (CXCL-8, CCL-5, CXCL-9, CCL-2, CXCL-10, IL-6, TNF, IL-2, IL-10, IFN-γ, IL-4, and IL-17A) were quantified using cytometric bead array. Our results demonstrated an increase in CXCL-9, CXCL-10, IL-6, IL-2, IL-10, and IL-17A molecules in the groups of patients who suffered Bothrops snakebites (AKI(-) and AKI(+)) before antivenom administration, when compared to HD. In the AKI(+) group, levels of CXCL-8 and CCL-2 molecules were elevated on admission and progressively decreased during the clinical evolution of patients after antivenom administration. In addition, in the signature analysis, these were produced exclusively by the group AKI(+) at T0. Thus, these chemokines may be related to the initiation and extension of AKI after envenomation by Bothrops and present themselves as two potential biomarkers of AKI at T0.