bluuebunny/crossref_metadata_2025 huggingface dataset:
PENENTUANBILANGANKROMATIKLOKASIGRAF PRISMA C n;n;n
Authors: DELLA SYAUMI YOZA , NARWEN NARWEN , EFFENDI EFFENDI
Published: August 2020

Misalkan G = (V, E) graf terhubung. Bilangan kromatik dari graf G adalah bilangan asli terkecil k sedemikian sehingga G mempunyai suatu pewarnaan-k titik sejati. Bilangan kromatik dari G dinotasikan dengan Ï‡(G). Misalkan Ï‡(G) = k, ini berarti titiktitik di G paling kurang diwarnai dengan k warna dan tidak dapat diwarnai dengan k âˆ’ 1 warna. jika titik-titik di G diwarnai dengan k warna maka tidak ada titik yang bertetangga mempunyai warna yang sama. Kelas warna pada G dinotasikan dengan Si, merupakan himpunan titik-titik yang berwarna i dengan 1 â‰¤ i â‰¤ k. Misalkan Î  = {S1, S2, Â· Â· Â· , Sk} merupakan partisi terurut dari V (G). Berdasarkan suatu pewarnaan titik, maka representasi v terhadap Î  disebut kode warna dari v, dinotasikan dengan cÎ (v). Kode warna cÎ (v) dari suatu titik v âˆˆ V (G) didefinisikan sebagai k-vektor, cÎ (v) = (d(v, S1), d(v, S2), Â· Â· Â· , d(v, Sk)) dimana d(v, Si) = min{d(v, x)|x âˆˆ Si} untuk 1 â‰¤ i â‰¤ k. Jika setiap titik yang berbeda di G memiliki kode warna yang berbeda untuk suatu Î , maka c disebut pewarnaan lokasi dari G. Minimum dari banyaknya warna yang digunakan pada pewarnaan lokasi dari graf G disebut bilangan kromatik lokasi. Pada tulisan ini akan dibahas bilangan kromatik lokasi graf prisma Cn,n,n yang dibentuk dari tiga graf lingkaran Cn, untuk n â‰¥ 3.Kata Kunci: kelas warna, kode warna, bilangan kromatik lokasi
BILANGAN KROMATIK LOKASI UNTUK GRAF POHON PISANG Bn,k
Authors: NUR MELATI , WELYYANTI DES , NARWEN NARWEN
Published: August 2020

Penelitian ini mengkaji kembali makalah [1] tentang penentuan bilangan kromatik lokasi untuk graf pohon pisang, Ï‡L(Bn,k). Misalkan Sk adalah graf bintang dengan k titik. Graf pohon pisang, Bn,k adalah suatu graf yang dibentuk oleh n buah graf bintang Sk dengan n â‰¥ 1 dan k â‰¥ 2, dimana satu daun dari setiap graf bintang Sk dihubungkan ke suatu titik baru yang disebut dengan titik akar. Bilangan kromatik lokasi dari Bn,k adalah minimum dari banyaknya warna yang digunakan sedemikian sehingga Bn,k mempunyai pewarnaan lokasi, dinotasikan dengan Ï‡L(Bn,k). Kata Kunci: Bilangan Kromatik Lokasi, Graf Bintang, Graf pohon pisang
PENGGUNAAN RUMUS BANACHIEWICZ-SCHUR YANG DIPERUMUM DALAM PENENTUAN INVERS DIPERUMUM MATRIKS PARTISI
Authors: WAHYUNI SRI , YANITA YANITA , NOLIZA BAKAR NOVA
Published: August 2020

Penelitian ini membahas tentang penentuan rumus Banachiewicz-Schur yang diperumum dalam menentukan invers diperumum matriks partisi. Untuk Menentukan invers diperumum matriks partisi, maka akan ditentukan {1}-invers dan {1, 2}-invers dari suatu matriks. Untuk menentukan {1}-invers dan {1, 2}-invers dari suatu matriks, maka dapat ditentukan dengan beberapa cara yaitu dengan menggunakan invers kiri, invers kanan, faktorisasi full rank, bentuk normal Hermite. Kata Kunci: Matriks partisi, rumus Banachiewicz-Schur, invers Moore-Penrose
A PROXY MODEL TO PREDICT WATERFLOODING PERFORMANCE IN CHANNELING DELTAIC SAND RESERVOIR
Authors: Yasutra Amega , Irawan Dedy , Sitompul Frans Ondihon
Published: August 2020

In recent days, waterflooding activities carried out as a part of secondary recovery. Before performing waterflooding, engineers have to perform reservoir simulation first to predict reservoir performance in order to waterflood. Generally, reservoir simulation is conducted by using numerical simulation method. Numerical simulation gives precise results although it depens on the availiability, quality, and quantity of reservoir characteristic and injection operation data. In addition, numerical simulation also time-consuming and quite complex to use. Proxy model is kind of machine learning. It’s able to predict performance of waterflooding quickly and easier to use. The result isn’t differ too much with numerical simulation method. Proxy model is an equation model that construct form quite many experiment data. This research is trying to predict performance of normal 5 spot waterflooding in reservoir with channeling deltaic sand sedimentation by using proxy model. The proxy model will be tested on a real field case. The results indicate that proxy model is able, faster, reliable and easy to use to predict waterflooding performance in such type of reservoir.
DIAMETER OPTIMIZATION IN MULTIPHASE PIPELINE NETWORK
Authors: Putradianto Ristiyan Ragil , Rahmawati Silvya Dewi
Published: August 2020

Optimization is a continuous work in oil and gas operation in every section by maximizing the profit and minimizing cost. One of the sections that can be optimized is production system, starting from the wellbore to separator through pipeline network. Simulation are made and conducted from reservoir to separator to see the pressure distribution along the pipeline with various diameter. The result will be subject to be optimized by putting pipeline cost into account. The simulation result shows that at some point, increasing in diameter has a good effect to the revenue thanks to the increasing production rate, but it also shows that the increasing diameter in all section is not always the best scenario due to high cost. Benefit-to-cost ratio is chosen to be the economical parameter to find the best diameter configuration.
Vapour Pressure Isotope Eﬀect on Evaporation from Pure Organic Phases - a PIMD Approach
Authors: Vasquez Luis , Dybala-Defratyka Agnieszka
Published: August 2020

Very often in order to understand physical and chemical processes taking place among several phases fractionation of naturally abundant isotopes is monitored. Its measurement can be accompanied by theoretical determination to provide a more insightful interpretation of observed phenomena. Predictions are challenging due to the complexity of the effects involved in fractionation such as solvent effects and non-covalent interactions governing the behavior of the system which results in the necessity of using large models of those systems. This is sometimes a bottleneck and limits the theoretical description to only a few methods.

In this work vapour pressure isotope effects on evaporation from various organic solvents (ethanol, bromobenzene, dibromomethane, and trichloromethane) in the pure phase are estimated by combining force field or self-consistent charge density-functional tight-binding (SCC-DFTB) atomistic simulations with path integral principle. Furthermore, the recently developed Suzuki-Chin path integral is tested. In general, isotope effects are predicted qualitatively for most of the cases, however, the distinction between position-specific isotope effects observed for ethanol was only reproduced by SCC-DFTB, which indicates the importance of using non-harmonic bond approximations.

Energy decomposition analysis performed using the symmetry-adapted perturbation theory (SAPT) revealed sometimes quite substantial differences in interaction energy depending on whether the studied system was treated classically or quantum mechanically. Those observed differences might be the source of different magnitudes of isotope effects predicted using these two different levels of theory which is of special importance for the systems governed by non-covalent interactions.
New Potential Drug Candidates Against SARS-CoV-2 Using Generative Model
Authors: Verma Madhusudan
Published: August 2020

Based on a recently solved structure (PDB ID: 6LU7), we developed a novel advanced deep Q-learning network with the fragment-based drug design (ADQN-FBDD) along with variational autoencoder with KL annealing and circular annealing for generating potential lead compounds targeting SARS-CoV-2 3CLpro . Structure-based optimization policy (SBOP) is used in reinforcement learning. The reason for using variational autoencoders is that it does not deviate much from actual inhibitors, but since VAE suffers from KL diminishing we have used KL annealing and circular annealing to address this issue. Researchers can use this compound as potential drugs against SARS-CoV-2.
Protein-Bound Calcium Phosphate in Uremic Rat Serum: A Quantitative Study
Authors: Fan Hong-Xing , Gou Bao-Di , Gao Yu-Xi , Wu Gang , Liu Shu-Hu , Li Fan , Zhang Tian-Lan
Published: August 2020

Protein-bound calcium (prCa) constitutes about 40% of serum total calcium, in which albumin is the most dominant protein. Given the chemical interaction between calcium and phosphate (Pi), the increased serum Pi in chronic kidney disease may cause changes in the composition and structure of the prCa fraction. Here, we report the phosphate binding on the protein-bound calcium in uremic rat serum. Using adenine-fed rats as a uremic model, we determined the levels of calcium and phosphate fractions in rat serum by ultrafiltration, and found that the level of protein-bound phosphate (prPi) in the uremic serum was markedly higher than in control. The elevated prPi level was comparable to the prCa level, consistent with the presence of protein-bound calcium phosphate pr(Ca)j-m(CaPi)m. We then confirmed its presence by ex vivo X-ray absorption near-edge structure spectroscopy, revealing the discrete state of the calcium phosphate clusters associated with protein. Finally, in a quantitative investigation using Ca- and Pi-boosted serum, we discovered the threshold concentration for the Pi binding on prCa, and determined the binding constant. The threshold, while preventing Pi from binding to prCa in normal condition, allows excess Pi to do so. The protein-bound calcium phosphate could act as a link between the metabolism of serum proteins and the homeostasis of phosphate and calcium, and it deserves further investigation whether the molar ratio of (prPi/prCa)×100% may serve as a serum index of the vascular calcification status in chronic kidney disease.
Biocatalytic Ketone Reductions Using Biobeads
Authors: Chew Jia Shen , Chi Lik Lee Ken , HO THI THANH NHA
Published: August 2020

Lee and coworkers offers a kind of new concept to enzyme immobilization and explores its suitability in the context of miniaturisation and high-throughput screening. Here, polystyrene-immobilized ketoreductases are compared with its non-immobilized counterparts in terms of conversion and stereoselectivity (both determined by chiral HPLC), and the study indicates that the BioBeads perform similarly (sometimes slightly more selective) which may be useful whenever defined micro-scale amounts of biocatalysts were required in high-throughput experiment settings.
In Silico Docking Analysis Revealed the Potential of Phytochemicals Present in Phyllanthus Amarus and Andrographis Paniculata, Used in Ayurveda Medicine in Inhibiting SARS-CoV-2
Authors: Hiremath Shridhar , H D Vinay Kumar , M Nandan , M Mantesh , S Shankarappa K , V Venkataravanappa , C R Jahir Basha , Reddy C N Lakshminarayana
Published: August 2020

No therapeutics and vaccines are available against SARS-CoV-2 at present. In the current study we have made an attempt to provide preliminary evidences for interaction of 35 phytochemicals from two plants (Phyllanthus amarus and Andrographis paniculata used in Ayurveda) with SARS-CoV-2 proteins (S protein, 3CLpro, PLpro and RdRp) through in silico docking analysis. The docking was performed with the aid of AutoDock Vina and ADME and other pharmacokinetic properties were predicted using SWISSADME and admetSAR
Chemoselective α-Sulfidation of Amides Using Sulfoxide Reagents
Authors: Leypold Mario , D’Angelo Kyan A. , Movassaghi Mohammad
Published: August 2020

The direct α-sulfidation of tertiary amides using sulfoxide reagents under electrophilic amide activation conditions is described. Employing readily available reagents, selective functionalization takes place to generate isolable sulfonium ions en route to α-sulfide amides. Mechanistic studies support the critical role of activated sulfoxides that promote the desired transformation. For benzylic amide substrates, a single-step protocol featuring a spontaneous dealkylation step of a sulfonium ion intermediate was developed.
Mitigating Damage to Hybrid Perovskites Using Pulsed-Beam TEM
Authors: VandenBussche Elisah , Clark Catherine , Holmes Russell , Flannigan David
Published: August 2020

Mitigation of electron-beam damage of methylammonium lead iodide (MAPbI3) using a modified laser-driven pulsed-beam TEM is demonstrated. For the same dose rates and total doses, it is shown that using a pulsed electron beam causes less damage to MAPbI3 than a conventional thermionic (random) beam. Varying electron-pulse size (i.e., number of electrons per pulse) and the time between pulses is also studied. It is found that damage increases with increasing pulse size and with decreasing time between pulses. Above a certain pulse size, more damage is caused by the pulsed beam than by conventional approaches.
Machine Learning Meets Mechanistic Modelling for Accurate Prediction of Experimental Activation Energies
Authors: Jorner Kjell , Brinck Tore , Norrby Per-Ola , Buttar David
Published: August 2020

Accurate prediction of chemical reactions in solution is challenging for current state-of-the-art approaches based on transition state modelling with density functional theory. Models based on machine learning have emerged as a promising alternative to address these problems, but these models currently lack the precision to give crucial information on the magnitude of barrier heights, influence of solvents and catalysts and extent of regio- and chemoselectivity. Here, we construct hybrid models which combine the traditional transition state modelling and machine learning to accurately predict reaction barriers. We train a Gaussian Process Regression model to reproduce high-quality experimental kinetic data for the nucleophilic aromatic substitution reaction and use it to predict barriers with a mean absolute error of 0.77 kcal/mol for an external test set. The model was further validated on regio- and chemoselectivity prediction on patent reaction data and achieved a competitive top-1 accuracy of 86%, despite not being trained explicitly for this task. Importantly, the model gives error bars for its predictions that can be used for risk assessment by the end user. Hybrid models emerge as the preferred alternative for accurate reaction prediction in the very common low-data situation where only 100–150 rate constants are available for a reaction class. With recent advances in deep learning for quickly predicting barriers and transition state geometries from density functional theory, we envision that hybrid models will soon become a standard alternative to complement current machine learning approaches based on ground-state physical organic descriptors or structural information such as molecular graphs or fingerprints.
A Silicon-Rhodamine Chemical-Genetic Hybrid for Far Red Voltage Imaging from Defined Neurons in Brain Slice
Authors: Ortiz Gloria , Liu Pei , Deal Parker , Nensel Ashley , Martinez Kayli , Shamardani Kiarash , Adesnik Hillel , Miller Evan
Published: August 2020

We describe the design, synthesis, and application of voltage-sensitive silicon rhodamines. Based on the Berkeley Red Sensor of Transmembrane potential, or BeRST, scaffold, the new dyes possess an isomeric molecular wire for improved alignment in the plasma membrane and contain 2' carboxylic acids for ready functionalization. Conjugation with secondary amines affords tertiary amides that localize to cellular membranes and respond to voltage changes with a 24% ΔF/F per 100 mV. When combined with a flexible polyethyleneglycol (PEG) linker and a chloroalkane HaloTag ligand, the new indicators, or isoBeRST dyes, enable voltage imaging from genetically defined cells and neurons. Covalent ligation of isoBeRST to cell surface-expressed HaloTag enzymes provides up to 3-fold improved labeling over previous, rhodamine-based hybrid strategies. We show that isoBeRST-Halo hybrid indicators achieve single-trial voltage imaging of membrane potential dynamics from dissociated rat hippocampal neurons or mouse cortical neurons in brain slices. With far-red/near infrared excitation and emission, turn-on response to action potentials, effective cell labeling in thick tissue, and excellent photostability, the new isoBeRST-Halo derivatives provide an important complement to voltage imaging in neurobiology.
Hydrodechlorination of Dichloromethane by a Metal-Free Triazole-Porphyrin Electrocatalyst: Demonstration of Main-Group Element Electrocatalysis
Authors: Williams Caroline , Lashgari Amir , Ang Marcus , Dhungana Pranita , Jiang Jianbing
Published: August 2020

In this work, the electrocatalytic reduction of dichloromethane (CH2Cl2) into hydrocarbons involving a main group element-based molecular triazole-porphyrin electrocatalyst H2PorT8 is reported. This catalyst converted CH2Cl2 in acetonitrile to various hydrocarbons (methane, ethane, and ethylene) with a Faradaic efficiency of 70% and current density of –13 mA/cm2 at a potential of –2.2 V vs. Fc/Fc+ using water as a proton source. The findings of this study and its mechanistic interpretations demonstrated that H2PorT8 was an efficient and stable catalyst for the hydrodechlorination of CH2Cl2 and that main group catalysts could be potentially used for exploring new catalytic reaction mechanisms.
Irrigation therapy in the treatment and prevention of pathology of the nasal cavity in young children
Authors:   Irkutsk State Medical University, Irkutsk, Russia, Subbotina Mariia V.
Published: August 2020

В статье описаны основные защитные механизмы слизистой оболочки респираторного тракта (эпителиальный барьер, мукоцилиарный клиренс, антимикробные пептиды, иммуноглобулин А, микробиота), которые препятствуют проникновению возбудителей респираторных инфекций. За-медляют работу мукоцилиарного транспорта низкая влажность вдыхаемого воздуха и слизистой оболочки, а также такие лекарственные веще-ства, как бензалкония хлорид, нафазолин, масляные капли, вяжущие препараты. Ускоряют работу реснитчатого эпителия карбоцистеин, макро-лиды, сальбутамол, солевые растворы. Особенностями детей грудного возраста являются недоразвитие кавернозной ткани в полости носа, не-умение дышать ртом при заложенности носа, присутствие разнообразной, в том числе кишечной, микрофлоры при рините. Особенностью течения ринита у детей раннего возраста часто является отсутствие жидкого секрета в носу, а шумное затрудненное дыхание обусловлено сухими короч-ками скопившегося секрета в задних отделах носовой полости, которые практически не удаляются аспирацией. Эти особенности обусловливают низкую эффективность деконгестантов при лечении ринита, которые к тому же могут приводить к нежелательным побочным эффектам: тахикар-дии, заторможенности, коме. Поддержание факторов защиты полости носа в нормальном состоянии играет важную роль в предотвращении ост-рой респираторной вирусной инфекции у детей раннего возраста. Этому способствует влажность окружающей среды, которую можно обеспечить применением специальных увлажнителей воздуха, а также орошением полости носа маленьких детей солевыми растворами. В статье описаны цели, показания и способы ирригационной терапии для профилактики и лечения ринита у грудных детей. Ключевые слова: новорожденные, ринит, дети грудного возраста, ирригационная терапия, гигиена полости носа. Для цитирования: Субботина М.В. Ирригационная терапия в лечении и профилактике патологии полости носа у детей раннего возраста. Педиат-рия. Consilium Medicum. 2020; 2: 50–55. DOI: 10.26442/26586630.2020.2.200217
Hypersensitivity reactions of insect genesis in children
Authors:   Center for Theoretical Problems of Physical and Chemical Pharmacology, Moscow, Russia, Mil'dzikhova Dzerassa R. , Niewozinskaya Zofia A. ,   Moscow Scientific and Practical Center of Dermatovenerology and Cosmetology, Moscow, Russia, Korsunskaya Irina M. ,   Center for Theoretical Problems of Physical and Chemical Pharmacology, Moscow, Russia
Published: August 2020

Насекомые составляют 1/2 живых организмов на планете. Укусы насекомых – распространенное явление, обычно не требующее обращения за специализированным лечением. Установить достоверную частоту аллергических реакций на укусы насекомых практически невозможно. Наибо-лее часто к специалисту обращаются по поводу выраженных кожных проявлений у детей ввиду укусов комаров, пчел, клопов, вшей и блох. Са-мый пик обращений приходится на летний период, так, по некоторым данным, укусы насекомых являются причиной обращений за помощью в 44% случаях. Кожные проявления аллергии зачастую обусловлены не самим укусом, а различными ферментами в слюне насекомого. Укусы насе-комых могут проявляться в виде крапивницы или реакций замедленного типа с папулами, язвами или пузырями, сохраняющимися в течение не-скольких недель. Основной проблемой при укусах насекомых является интенсивный зуд, который может стать причиной присоединения бактери-альной инфекции. Ввиду этого терапия инсектных аллергий в первую очередь направлена на купирование зуда. У детей в разных возрастных группах вне зависимости от локализации укусов может применяться гель, содержащий диметиндена малеат, демонстрирующий высокую эффек-тивность при аллергодерматозах. Ключевые слова: инсектная аллергия, укусы насекомых, зуд, диметиндена малеат. Для цитирования: Мильдзихова Д.Р., Невозинская З.А., Корсунская И.М. Реакции гиперчувствительности инсектного генеза у детей. Педиатрия. Consilium Medicum. 2020; 2: 46–49. DOI: 10.26442/26586630.2020.2.200219
Second malignant tumors in pediatric cancer survivors
Authors:   Blokhin National Medical Research Center of Oncology, Moscow, Russia, Pavlova Tatiana Yu. , Valiev Timur T. ,   Blokhin National Medical Research Center of Oncology, Moscow, Russia
Published: August 2020

Развитие второго злокачественного новообразования (ЗНО) является одним из наиболее серьезных отдаленных осложнений у детей, перенес-ших лечение по поводу первой злокачественной опухоли. Проводимое химиолучевое лечение является канцерогенным фактором развития вто-рого ЗНО. Органы и ткани детского организма с учетом степени зрелости, микроокружения, возраста и факторов образа жизни по-разному вос-приимчивы к канцерогенному воздействию химиопрепаратов и лучевой терапии. С учетом увеличения числа больных, излеченных от первого ЗНО, совершенствование терапии направлено на уменьшение риска развития вторых ЗНО по мере роста и развития детского организма. Опреде-ление факторов риска вторых ЗНО и разработка мер, направленных на снижение частоты развития вторых опухолей у лиц, излеченных от пер-вого онкологического заболевания, являются важной задачей современной онкопедиатрии. В настоящей работе представлены наиболее часто встречающиеся опухоли детского возраста, после терапии которых происходит развитие вторых ЗНО. Освещены факторы риска и сроки разви-тия вторых опухолей. Отдельное внимание уделено рекомендациям по наблюдению лиц, излеченных от ЗНО в детском возрасте. Ключевые слова: острый лейкоз, ретинобластома, лимфома, химиотерапия, лучевая терапия, вторые опухоли, лечение, дети. Для цитирования: Павлова Т.Ю., Валиев Т.Т. Вторые злокачественные опухоли у лиц, перенесших онкологическое заболевание в детстве. Педиатрия. Consilium Medicum. 2020; 2: 12–16. DOI: 10.26442/26586630.2020.2.200234
Payr's syndrome as the cause of chronic abdominal pain in children
Authors:   Republican Specialized Scientific Practice Medical Center of Pediatrics, Tashkent, Uzbekistan, Kamilova Altinoy T. , Ergashev Nasriddin Sh. ,   Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan, Nurmatova Nadira S. ,   Tashkent Pediatric Medical Institute, Tashkent, Uzbekistan, Geller Svetlana I. ,   Republican Specialized Scientific Practice Medical Center of Pediatrics, Tashkent, Uzbekistan
Published: August 2020

Болезнь Пайра возникает при стенозе толстой кишки, обусловленном ее перегибом в зоне селезеночной кривизны. Для этого симптомокомплекса характерны приступообразные боли в животе, чувство давления или полноты в левом верхнем квадранте живота, давление или жгучая боль в области сердца, сердцебиение, одышка, подгрудинная или прекардиальная боль с чувством страха, одно- или двусторонняя боль в плече с ирра-диацией в руку, боль между лопатками. В статье представлено описание клинического случая пациента с болезнью Пайра. Проанализированы все имеющиеся публикации, посвященные данной тематике. Ключевые слова: болезнь Пайра, поперечная ободочная кишка, боль в животе, запоры, илеоцекальный рефлюкс, дети, ирригография. Для цитирования: Камилова А.Т., Эргашев Н.Ш., Нурматова Н.С., Геллер С.И. Синдром Пайра как причина хронических болей в животе у детей. Педиатрия. Consilium Medicum. 2020; 2: 21–24. DOI: 10.26442/26586630.2020.2.200261
Aglomerados de alto risco e tendência temporal da sífilis congênita no Brasil
Authors: Oliveira Vinícius da Silva , Rodrigues Roberta Luiza , Chaves Vinícius Barros , Santos Thiago Soares dos , Assis Flaviane Marques de , Ternes Yves Mauro Fernandes , Aquino Érika Carvalho de
Published: August 2020

Objetivo. Determinar a existência de aglomerados de municípios (clusters) com alto risco para sífilis congênita (SC) no Brasil e descrever a tendência temporal da doença no país, comparando a população de crianças cujas mães realizaram o pré-natal com aquelas cujas mães não realizaram esse controle.

Métodos. Este estudo ecológico utilizou dados do Sistema de Informação de Agravos de Notificação (SINAN) e do Sistema de Informações sobre Nascidos Vivos (SINASC). Para a análise de aglomerados, a estatística de varredura Kulldorff foi aplicada à população de risco. A significância estatística foi determinada pelo logaritmo da razão de verossimilhança utilizando a distribuição discreta de Poisson. Para a análise das tendências das taxas de detecção do agravo, utilizou-se a regressão de Prais-Winsten. A análise foi realizada com os programas SatScan 9.4 e Stata 14.0.

Resultados. Clusters com taxas de detecção de 41,3, 44,4 e 188,1 casos/10 000 nascidos vivos foram identificados em 2001, 2009 e 2017, respectivamente. Em 2001, as taxas foram 8 vezes maiores nos clusters do que no restante do país; em 2009, foram 3,3 vezes maiores; e, em 2017, 2,5. Detectou-se uma tendência crescente na infecção por SC em todas as regiões e unidades da federação. As taxas foram 8,53 vezes maiores nos neonatos cujas mães não realizaram pré-natal (243,3 casos/1 000 nascidos vivos vs. 28,4 casos/1 000 nascidos vivos em mães com pré-natal).

Conclusões. A identificação de aglomerados de municípios com alto risco para SC e de tendências crescentes de infecção por SC em todo o país, mesmo na presença de pré-natal, indicam a necessidade de melhoria nas ações de saúde pública para o combate dessa doença.
Sistema Regional de Vacunas (SIREVA), vigilancia por laboratorio y desarrollo de vacunas para Streptococcus pneumoniae: análisis bibliométrico, 1993-2019
Authors: Di Fabio José Luis , Agudelo Clara Inés , Castañeda Elizabeth
Published: August 2020

Objetivo. Medir a través del análisis bibliométrico la productividad, la visibilidad y el impacto del Sistema Regional de Vacunas (SIREVA, un proyecto de la Organización Panamericana de la Salud) en sus dos componentes, la vigilancia por laboratorio y el desarrollo de vacunas.

Métodos. Se recuperaron de Scopus las publicaciones correspondientes a vigilancia por laboratorio y desarrollo de vacunas con sus referencias y citas y se aplicó la herramienta para obtener los indicadores bibliométricos. Se utilizó VOSviewer® 1.6.13 para visualizar las redes de coautoría por país y autores, y para realizar un análisis de coocurrencia de términos incluidos en los títulos y resúmenes de las publicaciones.

Resultados. Cumplieron los criterios establecidos para vigilancia por laboratorio y desarrollo de vacunas 173 y 128 publicaciones, respectivamente. Diez países de la Región fueron responsables de 90,8% de las publicaciones sobre vigilancia por laboratorio y 8 países de todas las publicaciones sobre desarrollo de vacunas. Las diez publicaciones más citadas sobre vigilancia por laboratorio y sobre desarrollo de vacunas estaban incluidas en 855 y 503 artículos, respectivamente; los principales autores se encontraban en Alemania, Australia, Bélgica, Brasil, China, Estados Unidos de América y el Reino Unido. La construcción y visualización de redes por coautorías de autores y países, y la coocurrencia de términos mostraron el trabajo en red y la colaboración intrarregional, así como permitieron hacer seguimiento a las diversas áreas de estudio y su evolución en el tiempo.

Conclusiones. El análisis bibliométrico permitió documentar de manera objetiva la productividad y visibilidad del Sistema Regional de Vacunas para Streptococcus pneumoniae en la Región.
Administrative Law Through a Regulatory Lens: Situating Judicial Adjudication Within a Wider Accountability Framework
Authors: Thwaites R , Knight Dean
Published: August 2020

No description supplied
Patriating our Head of State: A Simpler Path
Authors: Knight Dean
Published: August 2020

No description supplied
The Impact of Country of Brand Image on Symbolic Value of Luxury Brands
Authors: Qiu Qi , Wang Yonggui , Richard James , Wang Xiaoyan
Published: August 2020

No description supplied
'Word-of-Mouse' in China: In-Depth Interviews
Authors: Yang L , Fam Kim , Richard James
Published: August 2020

No description supplied
In Vitro Dissolution Interference Study in Presence of Paracetamol Tablets with Freshly Prepared Mango Juices on Simulated Gastrointestinal Digestion
Authors: Md. Didaruzzaman Sohel  , Faisal Asif  , Md. Helal Uddin Sumon  , Kaniz Fatema    , Md. Hassan Kawsar
Published: August 2020

This study is performed beneath In Vitro dissolution applying various mathematical approaches to observe the dissolution interference on simulated gastrointestinal digestion. In total, eight medicine samples wereollected in Bangladeshi market and the conventional approaches were followed to measure the result in gastric medium (pH 1.2). Altogether, the brands showed sensibly upper dissolution discharge; primarily P01 (98.9%), P08 (98.97%), P03 (98.32%) and P06 (98.24%) were released relatively faster than the other sample in 15 to 60 minutes. Along with the mango juice in the simulated gastric medium, the brands showed sensibly upper dissolution discharge; primarily P01 (98.83%), P07 (98.98%), P06 (98.78%) and P03 (98.38%) were released relatively faster than the other sample in 15 to 60 minutes. This result depicts to understand the proper release of kinetics with the help of various mathematical model such as Zero order, First order, Higuchi and Hixson-Crowell model etc. although Paracetamol can interact with the fruit juices, which may alter the drug release, drug absorption in the body and may also lead to an unwanted reaction.
Reflexões históricas e considerações teóricas em torno da educação a distância e da educação de adultos
Authors: Meirelles Kelen
Published: August 2020

Nosso trabalho se debruça sobre as questões relativas à Educação de Adultos. Focamos em especial os alunos que estão inseridos na Educação a Distância e presentes nas universidades privadas e públicas do nosso país. Isso por que tais alunos foram alvo das transformações tecnológicas e sociais nas últimas décadas. Partindo desse pressuposto, elencamos como objetivo da pesquisa identificar o processo histórico, as teorias e práticas para o aprendizado de adultos na educação à distância e o benefício social e econômico alcançado por esses. Para fundamentar a pesquisa lançamos mão da revisão bibliográfica de metodologias, teorias pertinentes a essas questões. Nesse sentido entendemos que o suporte teórico-metodológico discutido nesse trabalho tem sua forma ideal na Andragogia, priorizando autores como Lindeman, Knowles e Paulo Freire.
Breast cancer after chest irradiation for lymphoma: case report
Authors: Fontinele Danilo Rafael da Silva , Vieira Sabas Carlos
Published: August 2020

Breast cancer is one of the most common diseases among women worldwide. One of the risk factors for the development of this neoplasia is previous radiotherapy on the chest wall. Breast cancer, in turn, is the main long-term concern among women treated for lymphoma with radiation on the chest wall. Thus, we present a case of breast cancer that appeared 18 years after chest radiation for the treatment of lymphoma.
Vitiligo as a Köebner phenomenon after oncoplastic breast surgery
Authors: Paulinelli Régis Resende , Soares Leonardo Ribeiro , Seba Carla Paulinelli
Published: August 2020

The Köebner phenomenon is characterized by the appearance of several types of dermatological lesions after traumatic stimulation. The triggering of this phenomenon after breast surgery is uncommon and usually associated with psoriatic lesions. The aim of this study was to describe two cases of vitiligo as the initial manifestation of Köebner phenomenon after breast oncoplastic surgery. Case 1: female, 41 years old, no history of dermatological pathologies, presenting with tubular carcinoma in the right breast. Quadrantectomy and sentinel lymph node biopsy were performed, followed by reconstruction with mammoplasty. Later, the patient started on tamoxifen and underwent radiotherapy, without complications. Thirty days after treatment, the patient presented progressive depigmentation of the areola-papillary complex. Topical treatment was started with dermatological ointment tacrolimus monohydrate and, after one year, the condition was completely resolved. Case 2: 52-yearold woman with previous history of vitiligo on the face, with complete clinical response after dermatological treatment. She was diagnosed with ductal carcinoma in situ on the left breast and underwent quadrantectomy, by means of mammoplasty using the round block technique. Afterwards, she underwent radiotherapy and started tamoxifen. Four years after the surgery, she developed dyschromia in the ipsilateral periareolar region and was diagnosed with vitiligo. Local dermopigmentation was offered, but the patient opted for an expectant conduct and clinical follow-up. To our knowledge, this is the first description of Köebner phenomenon after breast oncoplastic surgery. In these cases, the therapeutic approach must be multidisciplinary and count on the assessment of multiple clinical and individual parameters.
Dança e Imaginação Criativa na CosmoPoesia de Rumi
Authors: guilhon Gisele
Published: August 2020

Esta comunicação pretende investigar a natureza da imaginação criativa do poeta persa Rumi (1207-1273), a partir das traduções da dançarina e historiadora Leandra Elena Yunis. Busca-se responder as se
Los desafíos de la inclusión en tiempos de COVID-19
Authors: Espinoza Parra Carmen Noemí , Maldonado Regalado Gabriela Alexandra , Rosero Poma Carlos Julio
Published: August 2020

La esencia del presente trabajo implica conocer el desafío de la educación inclusiva, ante la inesperada conmoción social que definitivamente afectó al mundo entero, más aún a la población vulnerable del sistema educativo. La interacción de los alumnos con el entorno de aprendizaje afianza conocimientos y fortalece el proceso educativo como proponen Canabal y Margalef (2017). Pero ¿qué sucede en tiempos de COVID-19? El uso de las TIC en el transcurso de este tiempo ha sido de gran importancia, puesto que ha permitido, que la educación se transforme en su totalidad; sin embargo, la brecha digital ha sido el mayor desafío para que los estudiantes obtengan aprendizajes significativos según Gómez, Alvarado, Martínez y Díaz (2018): así pues, la educación inclusiva se ve afectada ya que, las condiciones socioeconómicas y las facilidades tecnológicas no en todos los contextos es igual, de esa manera Torres y Cobo (2017): manifiestan que, la tecnología educativa se encarga del proceso de enseñanza aprendizaje a través del uso de las TIC; sin embargo, frente a estas condiciones en las que actualmente estamos pasando, las tecnologías son concebidas como una barrera más que limita el aprendizaje de los alumnos.
El Efecto del COVID-19 en la Economía y la Educación: Estrategias para la Educación Virtual de Colombia
Authors: Quintero Rivera Juan José
Published: August 2020

El virus del COVID-19 fue detectado por primera vez en diciembre del año 2019 en China, posteriormente los primeros meses del año 2020 se propagó por varios países del mundo, llegando de esta manera a Colombia.  Debido a la pandemia según la Cámara de Comercio de Bogotá (2020): hay más de 500,000 empresas en Colombia que afrontan una enorme presión financiera. Una vez que la amenaza de COVID-19 disminuya, la vida y el trabajo no pueden retroceder en el tiempo. La implementación del teletrabajo para el desarrollo laboral de la empresa y su personal es fundamental en tiempos de crisis sanitarias. El cierre de centros educativos, escuelas primarias, intermedias y universidades fue una de las primeras medidas adoptadas por el Gobierno Nacional para prevenir la propagación del coronavirus. De esta manera las instituciones educativas del país se enfrentan a una amenaza o dificultad para el aprendizaje. El objetivo de este ensayo es mostrar los efectos del COVID-19 en la economía y la educación colombiana como también las estrategias recomendadas para la educación virtual.
Las Tics: Una nueva tendencia en la educación inclusiva
Authors: Montenegro Conce María Elena , Muevecela Naranjo Silvia Catalina , Reinoso Reinoso María del Carmen
Published: August 2020

El verdadero desafío de la sociedad en el siglo XXI, es lograr la práctica de una educación inclusiva en los contextos educativos y sociedad en general, pues la tecnología juega un papel primordial en todos los sistemas de aprendizaje. La aplicación de la tecnología educativa mediante el uso de las plataformas virtuales, facilita el acceso al conocimiento de forma rápida, eficaz y personalizada; además, la misma se adapta a los diferentes ritmos y estilos de aprendizaje debido a que es un recurso multifuncional. Por lo tanto, lograr una verdadera educación inclusiva con el uso de los medios tecnológicos y su variedad de plataformas virtuales, facilitará el desarrollo de aprendizajes significativos, la aplicación del Diseño Universal de Aprendizaje DUA y promoverá un proceso de aprendizaje que respondan a las necesidades educativas de todos, a través de estrategias metodológicas activas. Finalmente, la web 2.0 como recurso educativo, permite la participación social de las personas a cualquier hora y en cualquier lugar, en donde el profesor es un mediador y el estudiante el protagonista de sus conocimientos y constructor de su formación.
Pertinencia de la investigación en la enseñanza del derecho
Authors: Peña Briceño Daniel Antonio , Díaz de Perales Aura Violeta , Salas Aular Franklin Gerardo de Gregorio
Published: August 2020

La calidad educativa es tema de permanente debate en el mundo, debido a la importancia que tiene para el fortalecimiento de las naciones de cara a los retos y desafíos que encierra el siglo XXI. Por eso, el presente estudio, tuvo como propósito el análisis de la pertinencia de la investigación en el ámbito de la enseñanza del derecho en Ecuador, desde una perspectiva teórica. Se constituyó en un estudio no experimental, de tipo documental y descriptivo. Se revisaron diferentes fuentes legales, bibliográficas y antecedentes investigativos. Producto de ello, se reporta un análisis de los fundamentos legales que rigen los fines de la educación superior en Ecuador como base para la disertación sobre consideraciones que inciden en la enseñanza del derecho, dando lugar a una serie de reflexiones sobre el rol del docente-investigador de significación en este ámbito.
Predisposición al consumo de sustancias en aspirantes a la carrera militar
Authors: Barreno López Joel Santiago , Pazmiño Tirado Claudio Danilo , Iriarte Pérez Luis Alfonso
Published: August 2020

El presente estudio tiene como objetivo determinar la relación entre las actitudes o maneras de pensar y los patrones de conducta frente al consumo de sustancias en aspirantes a la Carrera Militar. Comprende un estudio descriptivo y se ha utilizado la metodología cuantitativa para el análisis de poblaciones, se contó con la participación de 1118 sujetos de edades comprendidas entre los 18 y 26, con una media de edad de 20,41 años, a quienes se administró el Cuestionario de Actitudes hacia el Alcohol y Drogas Ilegales (CAADI) y el Autoinforme de Consumo de Sustancias Psicoactivas (AICA). Como resultados, se halló que la conciencia sobre los efectos negativos del consumo de sustancias se relaciona con el rechazo e índice de desagrado de consumo de drogas. Se encontró diferencias estadísticamente significativas entre aspirantes de primer y segundo año. Adicionalmente se identificó relación entre las actitudes y la disposición hacia las drogas, a pesar de tener la conciencia de los efectos nocivos. Por esta razón, concluimos que la conciencia de los efectos negativos sobre el consumo tiene relación significativa con la tendencia actitudinal en los aspirantes y la disposición comportamental. La identificación religiosa es un factor de protección frente al consumo de sustancias.
Pemanfaatan Dashboard pada Olah Data Mining Berdasarkan Analisa Pola Hubungan Data Kecelakaan Lalu Lintas Kota Pontianak
Authors: Ilhamsyah Ilhamsyah , Rahmayuda Syahru
Published: August 2020

Banyak faktor yang dapat mempengaruhi tingginya angka kecelakaan lalu lintas. Informasi mengenai faktor-faktor penyebab kecelakaan lalu lintas sangat dibutuhkan oleh masyarakat dan penegak hukum. Informasi tersebut dapat dijadikan pertimbangan sebagai tindakan antisipasi agar terhindar dari kecelakaan lalu lintas. Penelitian ini menganalisa pola hubungan jumlah kejadian kecelakaan lalu lintas dengan 13 faktor lainnya. Serta menganalisa kelompok lokasi dan waktu rawan kecelakaan lalu lintas. Berdasarkan pola analisa hubungan dibuat sebuah dashboard hasil olah data mining yang disajikan dalam bentuk informasi yang berkualitas. Data diperoleh dari Poltabes Unit LAKA Kota Pontianak Provinsi Kalimantan Barat. Terdapat dua pola analisa kecelakaan lalu lintas yaitu analisa faktor internal pelaku atau korban berupa status pendidikan, profesi dan usia. Sedangkan faktor eksternal terdiri atas lokasi kejadian dan waktu kejadian. Untuk menentukan pola hubungan jumlah kejadian kecelakaan lalu lintas dengan faktor-faktornya maka ditentukan nilai korelasi matriks setiap faktor dengan minimal nilai korelasi matriksnya sebesar 0.5. Variabel usia yang memenuhi kriteria adalah kategori dewasa dengan rentang umur 16- 40 tahun dengan nilai 0.564, tua dengan rentang umur > 41 tahun dengan nilai 0.679. Variabel kendaraan yang terlibat dengan kategori motor dengan nilai 0.531 dan mobil dengan rincian mobil penumpang, mobil box, bus dan kendaraan lainnya dengan nilai 0.598. Variabel pendidikan pelaku dan korban dengan kategori SLTA dengan nilai 0.598.
Global Warming and Its Multiple Causes
Authors: Slama Romdhane Ben
Published: August 2020

The global warming which preoccupies humanity, is still considered to be linked to a single cause which is the emission of greenhouse gases, CO2 in particular. In this article, we try to show that, on the one hand, the greenhouse effect (the radiative imprisonment to use the scientific term) took place in conjunction with the infrared radiation emitted by the earth. The surplus of CO2 due to the combustion of fossil fuels, but also the surplus of infrared emissions from artificialized soils contribute together or each separately, to the imbalance of the natural greenhouse effect and the trend of global warming. In addition, another actor acting directly and instantaneously on the warming of the ambient air is the heat released by fossil fuels estimated at 17415.1010 kWh / year inducing a rise in temperature of 0.122°C, or 12.2°C / century.
Cyclone Bomb Hits Southern Brazil in 2020
Authors: Gobato Ricardo , Heidari Alireza
Published: August 2020

An “explosive extratropical cyclone” is an atmospheric phenomenon that occurs when there is a very rapid drop in central atmospheric pressure. This phenomenon, with its characteristic of rapidly lowering the pressure in its interior, generates very intense winds and for this reason it is called explosive cyclone, bomb cyclone. With gusts recorded of 116 km/h, atmospheric phenomenon - “cyclone bomb” (CB) hit southern Brazil on June 30, the beginning of winter 2020, causing destruction in its influence over. One of the cities most affected was Chapecó, west of the state of Santa Catarina. The satellite images show that the CB generated a low pressure (976 mbar) inside it, generating two atmospheric currents that moved at high speed. In a northwest-southeast direction, Bolivia and Paraguay, crossing the states of Parana and Santa Catarina, and this draft that hit the south of Brazil, which caused the destruction of the affected states. Another moving to Argentina, southwest-northeast direction, due to high area of high pressure (1022 mbar). Both enhanced the phenomenon.
Development and Rapid Intensification of Tropical Cyclone OCKHI (2017) over the North Indian Ocean
Authors: B Geetha , S Balachandran
Published: August 2020

Tropical Cyclone OCKHI over the North Indian Ocean during 2017 underwent dramatic development and rapid intensification very close to the land - Sri Lanka, extreme South Indian coast and Lakshadweep area during its initial developmental stage and caused extensive damages over these areas. On examining the physical and structural mechanism involved in such development, it is observed that the initial development was associated with axi-symmetrisation of the vortex that could be associated with Vortex Rossby waves near the eyewall. Associated with the expulsion of high vorticity from the centre during asymmetry mixing, there was outward propagation of eddy angular momentum flux in the lower levels that strengthened a low level anticyclone to the northeast of the TC centre which in turn enhanced the cyclonic inflow near the TC centre. The rapid intensification phase was associated with vertical non-uniform heating with upper and lower tropospheric warming associated with latent heat release in convection. During the mature phase, the system sustained ‘very severe’ intensity even under increasing vertical shear and lower ocean heat flux under the influence of a break in the sub tropical ridge to the north of the system centre that enhanced the poleward outflow in the upper troposphere.
Toxic Effect of Different Neem Formulations against Pests and Mammals
Authors: Dimetry Nadia Zikry
Published: August 2020

Neem (Azadirachta indica A. Juss), prominently known as conventional medication is a local plant in India. Neem is regarded as a promising tree species which can be utilized in variety ways to benefit agricultural communities throughout the world. Neem based insect sprays were productive for the control of different insect species, yet their low lingering impact and absence of normalized definitions are issues for field application. Additionally, neem is fairly have harmful impact in nature. The use of nanotechnology as a mean for nanopesticides is in the beginning time of improvement. All things considered, the nanosphere definition demonstrated upgraded systemicity of the dynamic fixings and made its infiltration better in the plant, because of their little size. Nanoencapsulated pesticides can give controlled discharge energy, while proficiently upgrading piousness, dependability, and solvency. Nanoencapsulation can improve the vermin control proficiency over expanded spans by forestalling debasement of dynamic fixings under ecological conditions. This survey is hence composed to fundamentally evaluate the toxicological impacts i.e to examine the manifestations, systems and identifications of poisoning vertebrates particularly people. The prepared neem nano-plants contrasted with the bulk one have will be assessed on albino mice through two main approaches, i.e. determination of acute oral LD50 and study the toxic effect of sublethal dose (LD10) on some biochemical parameters. The effect of the prepared nano-formulations compared to the bulk one on various biomarkers, i.e. hematological, hepatotoxicity and nephrotoxicity in albino mice after an oral administration of sub-lethal dose during sub-acute treatment were taken in consideration. Hence, this review should thus offer an important guide for building up potential advantages are underlined, while little is known on security or the antagonistic impacts of nanoadvances in the agro-foodsystem.