bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect and Mechanism of Specnuezhenide on Chemotherapy-induced
Myelosuppression
Authors: Han Jiahong , Sun Nian , Xing Junjia , Fei Xuan , Cai Enbo , Su Fengyan
Published: February 2023

Objective:

This study aimed to investigate the therapeutic effect of Specnuezhenide on
myelosuppression induced by chemotherapy and clarify its mechanism.

Methods:

In this study, we measured peripheral blood cells, thymus index, spleen index, bone marrow
nucleated cells (BMNCs), and the number of cell colonies counted in vitro by hematopoietic
progenitor cells (HPCs) to determine the effect of SPN on cyclophosphamide (CTX)-induced myelosuppression.
The alterations in the expression of relevant proteins, the cell cycle, and cytokines
associated with hematopoietic cells were examined to better understand how it works.

Results:

In the cyclophosphamide-induced mouse model, our study discovered that SPN can increase
the number of peripheral blood cells and BMNCs after treatment, increase the thymus index
and decrease the spleen index, and promote the proliferation and differentiation of HPCs. SPN can
improve the production of cultured colonies in vitro, reduce the level of hematopoietic factors in vivo,
regulate the proportion of G0/G1 phase cells, and promote the normal growth and development of
cells. SPN can increase the expression levels of key proteins MEK and p-ERK in the MAPK signaling
pathway, which may be one of the important mechanisms for improving myelosuppression.

Conclusion:

SPN can enhance the hematological and immunological functions of myelosuppressionmice,
and it is hypothesized that SPN is extremely helpful to the hematopoietic and immune
functions of tumor patients following chemotherapy. SPN might be used to treat myelosuppression.
Additionally, high doses of SPN have a stronger therapeutic effect than low levels of SPN.
New Psychoactive Substances, New Behaviours, New Drug-drug Interactions:
Pharmacology of a Slam Session
Authors: Victorri-Vigneau Caroline , Schreck Benoit , Istvan Marion , Guerlais Marylène , Laforgue Edouard-Jules , Gérardin Marie , Grall-Bronnec Marie , Aquizerate Aurélie
Published: February 2023

Background:

Slamming has been increasing internationally for ten years, mostly among men who have
sex with men. Slamming consists of injecting psychostimulants (including new psychoactive substances-NPS) intravenously
to increase sexual performance.

Objective:

The objective of our work was to analyse drug-drug interactions related to slamming.

Methods:

Drawing upon a reported case of a slam session describing hour by hour the intake of substances, we performed
a drug-interaction analysis using international references and a comprehensive literature review. High doses
of sildenafil, GBL and 3-MMC were reported during the 40-hour session described. The specific drug-interaction
research was performed using 9 references and 65 of the 209 records identified in the literature review.

Results:

Pharmacological data regarding nonmedicated substances were scarce. Regarding pharmacodynamics, the
risk was high at the cardiovascular level and was related to the vasodilatation effect of sildenafil and the adrenergic
and serotoninergic properties of stimulants; this risk may increase with usual treatment (involving other vasodilators
or central depressants). Regarding pharmacokinetics, the major interactions concerned metabolism by CYP3A4 and
CYP2C9, leading to interactions, particularly with HIV medication.

Conclusion:

This innovative work provides pharmacological information on drugs that are commonly used in slamming,
allowing the development of effective medical-management protocols and the provision of risk-reduction
counselling.
Application and SARs of Pyrazolo[1,5-a]pyrimidine as Antitumor Agents
Scaffold
Authors: Zhang Yadong , Wen Di , Shen Jiwei , Tian Lu , Zhu Yan , Zhang Jifang , Zhao Leyan , Ding Shi , Liu Ju , Chen Ye
Published: February 2023

Pyrazolo[1,5-a]pyrimidines are fused heterocycles that have spawned many biologically active antitumor drugs and are important privileged structures for drug development. Pyrazolo[1,5-a]pyrimidine derivatives have played an important role in the development of antitumor agents due to their structural diversity and good kinase inhibitory activity. In addition to their applications in traditional drug targets such as B-Raf, KDR, Lck, and Src kinase, some small molecule drugs with excellent activity against other kinases (Aurora, Trk, PI3K-γ, FLT-3, C-Met kinases, STING, TRPC) have emerged in recent years. Therefore, based on these antitumor drug targets, small mole-cule inhibitors containing pyrazolo[1,5-a]pyrimidine scaffold and their structure-activity relation-ships are summarized and discussed to provide more reference value for the application of this par-ticular structure in antitumor drugs.
The Platelet Aggregation Inhibition Activity of Polyphenols can be Mediated
by 67kda Laminin Receptor: A New Therapeutic Strategy For the Treatment
of Venous Thromboembolism
Authors: Prakash Satya , Ghosh Amit , Nayek Arnab , Kiran Sheetal
Published: February 2023

Background:

Thrombotic disease is still a major killer. Aspirin, Ticagrelor, Clopidogrel,
etc. are the most widely used conventional antiplatelet drugs. The significant number of patients
who are resistant to this drug shows a poor outcome.

Objective:

Developing a new antiplatelet agent with a stable antiplatelet effect and minimal
bleeding risk is required for a patient who is resistant to antiplatelet drugs.

Methods:

Protein-ligand docking was performed using Autodock Vina 1.1.2 to study the interaction of 67LR with different Polyphenols.

Results:

Among the 18 polyphenols, thearubigin has the highest binding affinity towards 67LR and
gallic acid shows the lowest binding affinity. Among the 18 molecules, the top 4 molecules from the
highest to lowest binding affinity range from-10.6 (thearubigin) to -6.5 (Epigallocatechin).

Conclusion:

Polyphenols may inhibit platelet aggregation through 67 LR and can be an alternative
treatment for Thrombotic Disease. Moreover, it will be interesting to know whether polyphenols
interfere with the same pathways as aspirin and clopidogrel. Effective polyphenols could help
prototype the compound development of novel antiplatelet agents.
Minireview on the Mechanism for the Production of 5-hydroxymethylfurfural
from Biomass
Authors: Zeng Yongjian , Jiang Zhiwei , Hu Di , Guo Ruichao , Yan Kai
Published: February 2023

The synthesis of fuels and fine chemicals from lignocellulosic biomass is the most widely envisioned approach toward the implementation of renewable feedstocks. Significant advances have been
made in the selective conversion of biomass-derived platform chemicals. This minireview mainly elucidates the mechanism of biomass-derived 5-hydroxymethylfurfural (HMF) synthesis, including the dehydration of carbohydrates via acyclic and cyclic mechanisms as well as the Maillard reactions. It also highlights the fundamental aspects of reaction mechanisms, recent progress, and challenges.
Efficacy of Herbal Supplementation of Purslane Freeze-dried Juice for
Weight Loss: An 8-week Randomized, Double-blind, Placebo-controlled
Clinical Trial
Authors: Tafti Mehdi Ajdary , Moein Mahmoodreza , Babajafari Siavash , Haem Elham , Zarshenas Mohammad M.
Published: February 2023

Background:

Obesity is a condition that has been linked to several ailments. The current
investigation is a randomized, double-blind, placebo-controlled clinical experiment to examine how
Portulaca oleracea L. tablets affect hunger and Body Mass Index (BMI).

Methods:

A total of 70 healthy people aged 18 - 65 years old with a BMI >25.0 kg/m² were chosen
for an 8-week study. They were randomized into two groups, herbal medicine and placebo.
Anthropometry, laboratory tests, and appetite assessment by questionnaire were performed at
baseline and the end of the study period. In the end, the data were analyzed.

Results:

There were significant differences in appetite and BMI (p<0.05) between the two groups
after 8 weeks. No serious adverse events occurred in the two groups, and herbal medicine was well
tolerated. Purslane juice was found to be well tolerated and could be effective in the reduction of
appetite and BMI, either in obese or overweight individuals, following 8 weeks of intervention.

Conclusion:

The trial indicated the effectiveness of this extract on appetite and BMI. However,
long-term investigations with larger populations are needed to determine the tolerability and permanent
effectiveness of this natural medicament.
Liposomal Drug Delivery System as an Emerging Technique for Treatment
of “Neurodegenerative Diseases”
Authors: Agiwale Bharat Tukaram , Jadhav Abhish Bhagwan , Kshirsagar Sanjay Jayprakash , Bele Mrudula Hemant , Sonawane Chetan Ramrao , Kakad Smita Prakash , Ahirrao Sapana Prabhakar
Published: February 2023

In the last decade, the onset of neurodegenerative diseases (ND) has been strongly wide-spread due to the rapid increase in the world population. There are many neurodegenerative diseases such as Alzheimer’s disease, Parkinson’s disease, spinal muscular atrophy, Levy body disease, etc. Alzheimer’s disease and Parkinson’s disease are most commonly found. Neurodegenerative diseas-es occur due to the degradation of neurons in the brain and the spinal cord. The diagnosis of both diseases has increased, however, the successful treatment is still very limited because of the lower ability of the drug to cross the blood-brain barrier (BBB). It is a big challenge to deliver the drug to the brain, because only small and lipid-soluble agents cross the BBB, by considering this assump-tion, the liposomal drug delivery system is considered one of the effective treatments in neuro-degenerative diseases. Liposomes are considered to be an ideal carrier as they are flexible, biocom-patible, and can carry different types of therapeutic molecules across the BBB. This review focus on the potential use of lipid delivery system in the treatment of neurodegenerative diseases and the ap-plication of liposomes in Alzheimer's disease and Parkinson’s disease.
The Use of Antivirals against COVID-19 Infection will Reduce the Number
of Fatalities in Australia
Authors: Boretti Alberto
Published: February 2023

Australia finally permitted in July 2022 the use of oral antivirals against COVID-19. For the
previous 2.5 years, the local bureaucrats have prevented medical doctors to prescribe the antivirals successfully
used in other jurisdictions. Suddenly, they changed their mind, even if the opening of the restrictions
was limited to only two products not known to be the most effective, nor the cheapest, in between
the many available.
Analisis Kualitas Air Limbah Peternakan Sapi Perah Berdasarkan Nilai Biochemical Oxygen Demand (BOD), Chemical Oxygen Demand (COD), Ph dan Escherichia Coli di Kabupaten Kediri
Authors: Dameanti Fidi Nur Aini , Akramsyah S Muhammad Ali , Hasan Chyntia Silvi Yanti , Amanda Jacky Teguh , Sutrisno Rahayu
Published: February 2023

Peternakan sapi perah mampu menghasilkan produk susu yang bernilai ekonomi tinggi namun juga menghasilkan produk berupa limbah baik cair (air), padat dan gas. Limbah cairan pada peternakan sapi perah didominasi oleh air yang telah digunakan untuk pembersihan, sanitasi, pemanasan, pendinginan, dan pencucian lantai. Air limbah yang langsung dibuang tanpa melalui pengolahan dapat berdampak pada kualitas lingkungan sekitar. Pencemaran air di sekitar lingkungan peternakan sapi perah disebabkan karena kontaminasi dari limbah yang bisa dilihat dari nilai BOD, COD, pH dan keberadaan Escherichia. coli. Desain penelitian yang digunakan adalah penelitian deskriptif laboratorik yang dilakukan pada bulan Juni-September 2021. Pemilihan sampel dilakukan secara purposive sampling sehingga sampel yang diperoleh adalah 8 sampel dari Kelompok Ternak Sukses Bersama, Desa Deyeng, Kabupaten Kediri. Sampel air limbah dilakukan pengujian kadar BOD dan COD di Laboratorium Lingkungan Perum Jasa Tirta 1 dan analisis kadar pH serta deteksi E. coli. dilakukan di Laboratorium Mikrobiologi dan Imunologi Fakultas Kedokteran Hewan, Universitas Brawijaya. Pengujian kadar BOD dengan menggunakan metode APHA 5210B-2017, kadar COD berdasarkan SNI 6989.2:2009, pengujian pH berdasarkan SNI 6989.2:2019, dan deteksi E. coli dilakukan dengan uji penguat atau confirmed test uji kualitatif koliform. Hasil penelitian menunjukkan bahwa nilai BOD berkisar antara 3466 â€“ 18000 mg/L, nilai COD antara 12800 â€“ 66300 mg/L, nilai pH antar 7,3-8,04, dan seluruh sampel positif mengandung E.coli. Hasil tersebut menujukkan bahwa seluruh indikatir berada di atas ambang batas yang ditetapkan sehingga perlu dilakukan pengolahan air limbah yang lebih baik.
Steady-state cooperative effects in a continuously generating superradiant Raman laser
Authors: Tikhonov K. S.  , Roth A.
Published: February 2023

A generalized model of the continuously generating superradiant Raman laser is considered. The model includes competing individual and cooperative atomic processes arising from the interaction of atoms with external light fields. We show that proper selection of the model parameters leads to cooperative effects in the atomic active laser medium. We calculate the steady state values of the atomic polarization and two-atom correlations. Using the quantum regression theorem, we determine the spectral characteristics of the collectively emitted light. We use cumulant expansion to estimate the higher-order correlations between atoms. Keywords: superradiant laser, correlated states of atoms, cooperative effects, cumulant expansion.
Selection of the model functions for calculations of high-overtone intensities in the vibrational-rotational spectra of diatomic molecules
Authors: Medvedev E. S.  , Ushakov V. G.
Published: February 2023

The initial information on the molecular functions necessary for calculations of spectra is always of discrete nature, being either quantum-chemical calculations or experimental data. Selection of the model functions built on this information and then used to calculate the intensities of the fundamental transitions and low overtones is not restricted by any conditions, yet these same functions can result in errors when used for the high-overtone transitions. In particular, the errors are found in calculations for OH, PN, YO, CaO, PS, NS, SH, PH, and NO. We analyze the sources of the errors and give recommendations of how to avoid them. The molecular functions should be chosen such that the Normal Intensity Distribution Law is fulfilled. In order to increase the accuracy of the calculations, it is also desirable that their analytical properties in the complex plane be as close as possible to those of the real functions. Keywords: NIDL, repulsive branch, analytical functions, branch points, damped coordinate, saturation of the intensities.
Chemiluminescence of a Functionalized Graphene Surface
Authors: Plekhanov A. Yu.  , Puzyk M. V.  , Usikov A. S.  , Roenkov A. D.  , Lebedev A. A.  , Lebedev S. P.  , Klotchenko S. A.  , Vasin A. V.  , Makarov Yu. N.
Published: February 2023

To analyze the modification of the functionalized surface of graphene by protein molecules, a chemiluminescent enzyme-linked immunosorbent assay based method was proposed. Using the example of functionalized graphene (FG) purification, the possibilities of chemiluminescent control of the state of its surface are shown. Methods for purifying FG from protein molecules with the restoration of the ability to resorb protein molecules are discussed. It has been shown that the FG surface can be cleaned from sorbed proteins, and a biosensor can be designed again based on such purified graphene, including with a different specificity. Therefore, the graphene sensor can be used repeatedly. Keywords: functionalized graphene, 1-pyrenemethylamine hydrochloride, cyclic voltammetry, chemiluminescence, monoclonal antibodies, biosensors
Laser-induced linear dichroism in planar self-organized silver nanostructures
Authors: Gladskikh  I. A.  , Dadadzhanov D. R.  , Zakoldaev R. A.  , Vartanyan T. A.
Published: February 2023

A method for obtaining metallic plasmonic nanostructures with linear dichroism, based on the method of burning out constant spectral dips, is proposed. Isotropic granular silver films obtained by physical vapor deposition in vacuum were irradiated with linearly polarized laser radiation in the spectral region of the plasmon resonance of their constituent nanoparticles. As a result of irradiation, the silver nanostructures change their sizes and shapes, and the films acquire a pronounced linear dichroism. Both the magnitude and the spectrum of linear dichroism depend on the state of the isotropic film before irradiation, which can be changed by heat treatment. For the unannealed films the dichroism does not change the sign over the entire spectral range studied and corresponds to the expected increase in the depth of the spectral dip for the light polarized parallel to the laser radiation polarization plane. For the annealed films, which consist of more distinctly formed and better separated nanoparticles, the dichroism value is greater, and the spectrum turns out to be sign-changing. The appearance of linear dichroism after laser irradiation is due to the differences in the change in the shape and size of the initially anisotropic nanoparticles that make up an isotropic film as a whole, depending on their orientation relative to the polarization plane of the laser beam. Keywords: plasmon resonance, silver nanostructures, linear dichroism, laser radiation.
Siembra de cítricos
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

El presente vídeo muestra un paso a paso de cómo se realiza la siembra de cítricos, aconseja realizar un análisis de suelos previamente y aplicar yeso agrícola antes de la siembra de la planta.
Nematodos en bananito
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

Tener un buen manejo de los suelos aumenta la vitalidad de las plantas desde la raíz, esto conduce a que se aumente la capacidad de nutrición. En este clip se brindan recomendaciones para evitar la presencia de nematodos en el cultivo de bananito.
Ola invernal: diagnóstico y manejo fitosanitario
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

Con el fin de mitigar el impacto de la ola invernal en el sector agropecuario, una de las estrategias que lidera Corpoica es la de el diagnóstico positivo y manejo fitosanitario. Han sido visitados decenas de productores afectados por plagas o enfermedades en los departamentos de Córdoba, Sucre, Bolívar, Atlántico, Cundinamarca y Valle del Cauca.
Pastoreo
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

El pastoreo es la forma más eficiente de aprovechar los recursos en las zonas áridas y marginales. Aprenda en éste clip tecnológico a sacar el mayor provecho de cada zona.
Poda de formación
Authors:   Ministerio de Agricultura y Desarrollo Rural, Bogotá (Colombia),   Corporación colombiana de investigación agropecuaria, Mosquera (Colombia)
Published: February 2023

En la poda de producción es importante tener en cuenta algunos aspectos como: variedad, clima, fertilización y riego, aprenda en este clip tecnológico la forma adecuada y las ventajas de practicar la poda de producción en su cultivo de guayaba.
Influences on Patient Uptake of and Engagement With the National Health Service Digital Diabetes Prevention Programme: Qualitative Interview Study
Authors: Ross Jamie , Cotterill Sarah , Bower Peter , Murray Elizabeth
Published: February 2023

Background

Digital diabetes prevention programs (digital-DPPs) are being implemented as population-based approaches to type 2 diabetes mellitus prevention in several countries to address problems with the uptake of traditional face-to-face diabetes prevention programs. However, assessments of digital-DPPs have largely focused on clinical outcomes and usability among those who have taken them up, whereas crucial information on decision-making about uptake (eg, whether a user downloads and registers on an app) and engagement (eg, the extent of use of an app or its components over time) is limited. Greater understanding of factors that influence uptake and engagement decisions may support large-scale deployments of digital-DPPs in real-world settings.

Objective

This study aimed to explore the key influences on uptake and engagement decisions of individuals who were offered the National Health Service Healthier You: Digital Diabetes Prevention Programme (NHS-digital-DPP).

Methods

A qualitative interview study was conducted using semistructured interviews. Participants were adults, aged ≥18 years, diagnosed with nondiabetic hyperglycemia, and those who had been offered the NHS-digital-DPP. Recruitment was conducted via 4 providers of the NHS-digital-DPP and 3 primary care practices in England. Interviews were conducted remotely and were guided by a theoretically informed topic guide. Analysis of interviews was conducted using an inductive thematic analysis approach.

Results

Interviews were conducted with 32 participants who had either accepted or declined the NHS-digital-DPP. In total, 7 overarching themes were identified as important factors in both decisions to take up and to engage with the NHS-digital-DPP. These were knowledge and understanding, referral process, self-efficacy, self-identity, motivation and support, advantages of digital service, and reflexive monitoring. Perceptions of accessibility and convenience of the NHS-digital-DPP were particularly important for uptake, and barriers in terms of the referral process and health care professionals’ engagement were reported. Specific digital features including health coaches and monitoring tools were important for engagement.

Conclusions

This study adds to the literature on factors that influence the uptake of and engagement with digital-DPPs and suggests that digital-DPPs can overcome many barriers to the uptake of face-to-face diabetes prevention programs in supporting lifestyle changes aimed at diabetes prevention.
From Social Network to Peer Support Network: Opportunities to Explore Mechanisms of Online Peer Support for Mental Health
Authors: Rayland Amy , Andrews Jacob
Published: February 2023

An increasing number of psychological interventions are shifting to online modes of delivery. One such intervention is peer-to-peer support, which in this context may provide internet users living with mental health disorders an opportunity to connect with and support others living with similar conditions. This paper presents a call for further research into how platforms such as Facebook could be used as channels for peer support and the mechanisms that may underlie their effectiveness. We discuss the background of peer support, how it has transitioned online, and consider theories and models that may have relevance. We also consider the importance of moderation within online peer support and the development of specific social network–based online interventions. We conclude that for social network sites to be used as peer-to-peer support interventions, more research is needed to understand their effectiveness, the role of moderation in these communities, and the mechanisms that produce the benefits experienced by users.
A Personalized Mobile Cessation Intervention to Promote Smokers From the Preparation Stage to the Action Stage: Double-blind Randomized Controlled Trial
Authors: Lin Haoxiang , Wang Ying , Xing Yanling , Han Yinglian , Zhang Chengqian , Luo Ting , Chang Chun
Published: February 2023

Background

Most mobile cessation studies have found that such interventions have a higher quitting rate than interventions providing minimal smoking cessation support. However, why such interventions are effective has been almost unstudied by researchers.

Objective

This paper describes the principles of the personalized mobile cessation intervention-based WeChat app and used generalized estimated equations to assess why a personalized mobile cessation intervention was more likely to promote smokers from the preparation stage to the action stage than a nonpersonalized intervention.

Methods

This is a 2-arm, double-blind, randomized controlled trial in five cities in China. The intervention group received a personalized mobile cessation intervention. The control group received a nonpersonalized SMS text message smoking cessation intervention. All information was sent by the WeChat app. The outcomes were the change in protection motivation theory construct scores and the change in transtheoretical model stages.

Results

A total of 722 participants were randomly assigned to the intervention or control group. Compared with those who received the nonpersonalized SMS text message intervention, smokers who received the personalized intervention presented lower intrinsic rewards, extrinsic rewards, and response costs. Intrinsic rewards were determinants of stage change, thus explaining why the intervention group was more likely to promote smokers from the preparation stage to the action stage (odds ratio 2.65, 95% CI 1.41-4.98).

Conclusions

This study identified the psychological determinants at different stages to facilitate smokers moving forward to the next stage of quitting behavior and provides a framework to explore why a smoking cessation intervention is effective.

Trial Registration

Chinese Clinical Trial Registry ChiCTR2100041942; https://tinyurl.com/2hhx4m7f
The Next Frontier of Remote Patient Monitoring: Hospital at Home
Authors: Whitehead David , Conley Jared
Published: February 2023

Remote patient monitoring (RPM) has shown promise in aiding safe and efficient remote care for chronic conditions; however, its use remains more limited within the hospital at home (HaH) model of care despite a significant opportunity to increase patient eligibility, improve safety, and decrease costs. HaH could achieve these goals by further adopting the 3 primary modalities of RPM (ie, vital sign, continuous single-lead electrocardiogram, and fall monitoring). With only 2 in-person vital sign checks required per day, HaH patient eligibility is currently often limited to lower-acuity cases. The use of vital sign RPM within HaH could better match the standard clinical practice of vital sign checks every 4-8 hours and enable safe care for appropriate moderate-acuity medical and surgical floor-level patients not traditionally enrolled in HaH. Robust, efficient collection of more frequent vital signs via RPM could expand patient eligibility for HaH and create a digital health safety net that enables high quality care. Similarly, our experience at Massachusetts General Hospital has demonstrated that appropriate use of continuous single-lead electrocardiogram RPM can also expand HaH enrollment, particularly for patients with acute decompensated heart failure. Through increasing enrollment of patients in HaH, RPM stands to enable more patients to reap the potential safety benefits of home hospitalization, including decreased rates of delirium and hospital-acquired infections, and better avoid aspects of posthospital syndrome. Furthermore, instituting fall detection RPM allows care teams to further HaH patient safety during their episode of acute care and develop enhanced mitigation strategies to avoid falls post home hospitalization. RPM also has the potential to assist HaH in achieving greater economies of scale and decreasing direct variable costs. By expanding HaH eligibility, RPM could enable HaH programs, which have traditionally operated under capacity, to care for a larger census and decrease allocated fixed costs per hospitalization. Additionally, RPM for HaH could further optimize hybrid in-home and remote nurse or physician evaluations, decreasing costs on a per-episode basis by up to an estimated 3.5%. Overall, RPM holds great promise to increase patient eligibility and patient safety while decreasing costs. However, it is in its infancy in achieving its potential to advance the HaH model of care; further research and experience that inform operational and technical as well as policy considerations are needed.
Attitudes and Experiences of Clinicians After Mandated Implementation of Open Notes by the 21st Century Cures Act: Survey Study (Preprint)
Authors: Leonard Sophia M , Zackula Rosalee , Wilcher Jonathan
Published: February 2023

BACKGROUND

On December 13, 2016, the US Congress enacted the 21st Century Cures Act (hereafter the Cures Act), which contained the Final Rule mandate that took effect on April 5, 2021. Since then, health systems have been required to provide patients digital access to their eHealth information “without delay” and without charge.

OBJECTIVE

This study aimed to assess clinicians’ initial experiences with, and attitudes toward, sharing visit notes with patients after being mandated to do so by the Cures Act and to determine clinician preferences regarding instant record release.

METHODS

This cross-sectional survey study was conducted between June 10, 2021, and August 15, 2021, at the University of Kansas Health System, a large academic medical center in Kansas City, Kansas, United States. Participants included clinicians currently employed by the health system, including resident and attending physicians, physician assistants, nurse practitioners, and critical care and emergency medicine registered nurses.

RESULTS

A total of 1574 attending physicians, physician assistants, and nurse practitioners, as well as 506 critical care and emergency medicine nurses, were sent invitations; 538 (34.18%) and 72 (14.2%), respectively, responded. Of 609 resident physicians, 4 (response rate not applicable because it was unknown how many residents viewed the website while the link was available) responded. The majority of respondents were attending physicians (402/614, 65.5%) and within the department of internal medicine (160/614, 26.1%). Most agreed that sharing visit notes was a good idea (355/613, 57.9%) and that it is important to speak with the patients before they accessed their records (431/613, 70.3%). Those who agreed that sharing visit notes is a good idea tended to view the practice as a useful tool for engaging patients (“Agree”: 139/355, 39.2%; “Somewhat agree”: 161/355, 45.4%; P<.001) and experience no change in the clinical value of their notes for other clinicians (326/355, 91.8%; P<.001). Those who disagreed (or were neutral) tended not to encourage patients to read their notes (235/258, 91.1%; P<.001) and were more likely to experience a change in their charting practice (168/257, 65.4%; P<.001) and increased time charting (99/258, 38.4%; P<.001).

CONCLUSIONS

The findings of this study may be generalizable to institutions similar to the University of Kansas Health System, and the clinician testimonies gathered in this study may provide valuable insight into the initial opinions and experiences of clinicians at these institutions. In addition, these clinician experiences collected early in the transition period may be used to guide future health policy implementation and to understand how best to prepare clinicians for these changes in practice.
Smart Glasses for Supporting Distributed Care Work: Systematic Review (Preprint)
Authors: Zhang Zhan , Bai Enze , Joy Karen , Ghelaa Partth Naressh , Adelgais Kathleen , Ozkaynak Mustafa
Published: February 2023

BACKGROUND

Over the past 2 decades, various desktop and mobile telemedicine systems have been developed to support communication and care coordination among distributed medical teams. However, in the hands-busy care environment, such technologies could become cumbersome because they require medical professionals to manually operate them. Smart glasses have been gaining momentum because of their advantages in enabling hands-free operation and see-what-I-see video-based consultation. Previous research has tested this novel technology in different health care settings.

OBJECTIVE

The aim of this study was to review how smart glasses were designed, used, and evaluated as a telemedicine tool to support distributed care coordination and communication, as well as highlight the potential benefits and limitations regarding medical professionals’ use of smart glasses in practice.

METHODS

We conducted a literature search in 6 databases that cover research within both health care and computer science domains. We used the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) methodology to review articles. A total of 5865 articles were retrieved and screened by 3 researchers, with 21 (0.36%) articles included for in-depth analysis.

RESULTS

All of the reviewed articles (21/21, 100%) used off-the-shelf smart glass device and videoconferencing software, which had a high level of technology readiness for real-world use and deployment in care settings. The common system features used and evaluated in these studies included video and audio streaming, annotation, augmented reality, and hands-free interactions. These studies focused on evaluating the technical feasibility, effectiveness, and user experience of smart glasses. Although the smart glass technology has demonstrated numerous benefits and high levels of user acceptance, the reviewed studies noted a variety of barriers to successful adoption of this novel technology in actual care settings, including technical limitations, human factors and ergonomics, privacy and security issues, and organizational challenges.

CONCLUSIONS

User-centered system design, improved hardware performance, and software reliability are needed to realize the potential of smart glasses. More research is needed to examine and evaluate medical professionals’ needs, preferences, and perceptions, as well as elucidate how smart glasses affect the clinical workflow in complex care environments. Our findings inform the design, implementation, and evaluation of smart glasses that will improve organizational and patient outcomes.
Use of Digital Health Technology Among Older Adults With Cancer in the United States: Findings From a National Longitudinal Cohort Study (2015-2021) (Preprint)
Authors: Zhou Weijiao , Cho Youmin , Shang Shaomei , Jiang Yun
Published: February 2023

BACKGROUND

Despite the benefits of digital health technology use, older adults with cancer (ie, aged 65 years) have reported challenges to technology adoption. However, there has been a lack of a good understanding of their digital health technology use patterns and the associated influential factors in the past few years.

OBJECTIVE

This study aimed to examine the trends in and factors associated with digital health technology use among older adults with cancer.

METHODS

The National Health and Aging Trends Study (NHATS) data set is a national longitudinal cohort study with annual survey waves of Medicare beneficiaries 65 years and older. Participants were community-dwelling older adults who self-reported previous or current cancer diagnoses in each round. The study sample size of each round ranged from 1996 (2015) to 1131 (2021). Digital health technology use was defined as using the internet or online in the last month to order or refill prescriptions, contact medical providers, handle Medicare or other insurance matters, or get information about their health conditions. The association of sociodemographics, clinical factors (self-rated health, chronic conditions, difficulties in activities of daily living, dementia, anxiety, and depression), and physical function (Short Physical Performance Battery and grip strength) with digital health technology use was examined using design-based logistic regression. All statistical analyses accounted for the complex sample design.

RESULTS

The prevalence of any digital health technology use increased from 36% in 2015 to 45% in 2019. In 2020-2021, which was amid the COVID-19 pandemic, it ranged from 51% to 52%. In terms of each digital health technology use behavior, in 2015, overall, 28% of older cancer survivors used digital health technology to obtain health information, followed by contacting clinicians (19%), filling prescriptions (14%), and handling insurance (11%). Greater use of digital health technology was associated with younger age, being White, having a college or higher education, having a higher income, having more comorbidities, nondementia, and having a higher gait speed.

CONCLUSIONS

Digital health technology use in older adults with cancer has gradually increased, particularly during the COVID-19 pandemic. However, socioeconomic and racial disparities have remained in older cancer survivors. Additionally, older adults with cancer may have some unique features associated with digital health technology use; for example, their use of digital health may be increased by their comorbidities (ie, health care needs) and reduced by their frailty.

CLINICALTRIAL
Physician well-being during COVID-19: results from a randomized trial testing a light-touch, SMS intervention (Preprint)
Authors: Larson Emily E. , Salomon-Ballada Sebastian , Pullen Naomi , Gajjar Jainita , Callender Laura , Tregebov Sasha , Wright James G.
Published: February 2023

BACKGROUND

The COVID-19 pandemic yielded extraordinary stressors and well-being challenges for physicians.

OBJECTIVE

We sent light-touch SMS messages to improve well-being in Ontario physicians and sought to determine which types of messages were most effective.

METHODS

We conducted a randomized longitudinal study with three trial arms for comparison of changes. All residents and practicing physician members of the Ontario Medical Association with available mobile numbers were randomly assigned to a trial arm: messages with well-being resources, stories from fellow Ontario physicians, or combined resources and stories. Baseline and endline data were collected through online surveys primarily using the short Warwick-Edinburgh Mental Wellbeing Scale, with single-item ‘pulse surveys’ delivered via SMS weekly through the intervention.

RESULTS

3,356 and 1,230 participants completed the baseline and endline surveys, respectively. Of these, 614 participants also completed the endline survey and were included in our analyses. There were no significant differences in well-being, happiness, anxiety, life satisfaction, or worthwhileness across treatment groups, nor in how helpful participants found the messages. Participants in the resources-only trial arm were more likely (p=0.036) to report reading the messages compared to members in other groups.

CONCLUSIONS

Texts with stories from peer physicians and referral to well-being resources alone or in combination were not superior to each other in improving physicians’ well-being. Our findings support the notion that interventions focused on individual physicians alone are unlikely to address poor well-being and burnout among physicians. Further research is needed on the use of digital-based interventions in relation to well-being and burnout, particularly as health human resource well-being and sustainability are key to post-pandemic recovery efforts.

CLINICALTRIAL

ClinicalTrials.gov NCT04803812
What’s Next for Modernizing Gender, Sex, and Sexual Orientation Terminology in Digital Health Systems? Viewpoint on Research and Implementation Priorities (Preprint)
Authors: Queen Roz , Courtney Karen L , Lau Francis , Davison Kelly , Devor Aaron , Antonio Marcy G
Published: February 2023

UNSTRUCTURED

In 2021, Canada Health Infoway and the University of Victoria's Gender, Sex, and Sexual Orientation Research Team hosted a series of discussions to successfully and safely modernize gender, sex, and sexual orientation information practices within digital health systems. Five main topic areas were covered: (1) terminology standards; (2) digital health and electronic health record functions; (3) policy and practice implications; (4) primary care settings; and (5) acute and tertiary care settings. In this viewpoint paper, we provide priorities for future research and implementation projects and recommendations that emerged from these discussions.
Analysis of Jixi Museum
Authors: Yang Lifan
Published: February 2023

Jixi Museum connects the past and the future. Mr. Li Xinggang uses Jixi’s rich cultural heritage to lay a strong cultural atmosphere for the museum. This paper analyzes and understands its architectural style, spatial layout, material selection and other aspects. Learn the expression techniques and artistic effects of Jixi Museum.
Emprendimiento y género: su análisis desde la perspectiva de la Teoría de la Conducta Planificada
Authors: Vera Muñoz José Gerardo , Vera Muñoz María Antonieta Monserrat , Martínez Méndez Rafaela
Published: February 2023

Resumen
Objetivo: analizar si entre los estudiantes de educación superior existe un impacto relevante en la intención emprendedora que sea atribuible a la diferencia de género, aplicando el modelo de la Teoría de la Conducta Planificada modificado por Vamvaka et al. (2020).
Diseño metodológico: se tomó una muestra a un grupo de estudiantes de la Facultad de Contaduría Pública (FCP) de la Benemérita Universidad Autónoma de Puebla (BUAP), con estos datos se realizó un análisis descriptivo que se complementó con una prueba de hipótesis para muestras apareadas.
Resultados: a nivel descriptivo, el promedio de los estudiantes fue superior al  promedio de las estudiantes en cada una de las variables del modelo de Vamvaka et al. (2020). Sin embargo, las pruebas de hipótesis arrojaron que únicamente en la variable control conductual percibido, se encontró evidencia estadística significativa para suponer que los promedios de los estudiantes varones son superiores a los promedios de las estudiantes mujeres.
Limitaciones: el tamaño de la muestra de 70 estudiantes; sólo se incluyeron estudiantes de las licenciaturas que se ofertan en la FCP de la BUAP.
Hallazgos: la diferencia de género únicamente resultó relevante en el control conductual percibido y no tuvo un efecto significativo en la actitud y en la intención emprendedora. Los puntajes mayores y menores tanto de las estudiantes como de los estudiantes se obtuvieron para la variable actitud y la variable intención respectivamente, lo que permite suponer que existe una percepción agradable y optimista por la actividad emprendedora, pero escaso interés y compromiso con su ejecución.
Fracking en el orden jurídico mexicano: un ensayo desde el extractivismo energético y el despojo hídrico por contaminación
Authors: Jacobo-Marín Daniel
Published: February 2023

El artículo analiza la extracción de hidrocarburos mediante fractura hidráulica (fracking) en México. Se discute el extractivismo energético como el modelo hegemónico de producción y consumo de combustibles fósiles y, de forma particular, como prototipo neoliberal de gestión de la energía. Se examina la relación agua-energía desde una perspectiva crítica, subrayando la concesión de derechos de agua para la estimulación de yacimientos no convencionales. Se documenta que la reglamentación explícita del fracking intervino la asignación de aprovechamientos hidráulicos y el orden de prelación de usos. En todo caso, dichas cuestiones agudizan la competencia por el agua en tierras de propiedad social colectiva. Se concluye que la fractura hidráulica constituye un mecanismo de despojo hídrico por contaminación.
El valor de la vida del embrión en la jurisprudencia estadounidense y argentina
Authors: Zambrano Pilar , Sacristán Estela B.
Published: February 2023

Este trabajo se propone comparar la jurisprudencia constitucional estadounidense y la jurisprudencia constitucional argentina en lo que concierne al valor jurídico de la vida del embrión, con miras a inferir los argumentos que en uno y otro ámbito se proponen respecto de la aceptación o el rechazo de la distinción conceptual entre ser humano y persona en sentido jurídico.
Consumer Perception on Influence of Technology in Banking Sector
Authors: Bharawa Aparna , Patel Neha , Rao Dr. Mayur
Published: February 2023

Abstract: This study seeks to understand how respondents view various technological aspects of e-banking, such as ATM services, Internet banking services, telephone banking services, and mobile banking services, and how these aspects affect the banking activities of both public and private sector banks.
The analysis of fatigue resistance of bridge structures made of aluminum alloys
Authors:   Moscow State University of Civil Engineering (National Research University) (MGSU), Korgin Andrey V.
Published: February 2023

Introduction. The author has developed a method for the fatigue resistance analysis of bridge structures made of aluminum alloys subjected to polycyclic loading. The author suggests that this method should be introduced into the currently enhanced regulatory documentation focused on the analysis of highway bridges made of aluminum alloys. Materials and methods. The method is based on the results of integrated laboratory testing of a number of aluminum alloys 1915T, AD35 T1, 1565hM, EN AW-6082 T6 that have good prospects in terms of the production of bridge structures. Physical-mechanical and fatigue characteristics were identified in the course of the static testing of specimens of these alloys before the fatigue cracking at different values of the cycle asymmetry coefficient. The theoretical fundamentals of the method stem from the domestic research on the fatigue resistance analysis of steel structures and foreign regulatory materials on the fatigue resistance analysis of bridge structures made of aluminum alloys. Results. The reliability of the new method was verified in the course of static and fatigue testing of a full-scale pedestrian bridge made of 1915T alloy and orthotropic plates made of EN AW-6082 T6 alloy, designed by NRU MGSU and manufactured by the Russian plants GS-Reserve, KraMZ and Sespel using advanced innovative technologies of extrusion and friction stir welding. Discrepancies between the experimental findings and the results of the analysis, made pursuant to the proposed methodology, are within 5–20 %. Conclusions. The proposed method can also be applied to other types of structures made of aluminum alloys, such as tanks, pipelines, high-rise structures, and other items that are subject to multiple cyclic effects.