bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Pendistribusian ZIS dalam Meningkatkan Kesejahteraan Mustahik di Yayasan Indonesia Mulia Bekasi
Authors: Anisa Silmi Kapah
Published: January 2022

Islam requires its people to be able to set aside some of their assets to those who are entitled, including zakat, infaq and alms (ZIS). In addition, the distribution of zakat serves to help the poor in fulfilling their daily needs. Therefore, the more muzakki who pay zakat, the welfare of mustahik will increase optimally. Welfare is based on the concept of maqasid sharia which includes all aspects related to the afterlife, namely religion, soul, mind, lineage and property. This study aims to analyse the distribution mechanism of ZIS funds at Yayasan Indonesia Mulia Bekasi and the implications of the distribution on the welfare of mustahik. This research used descriptive qualitative method with primary and secondary data approach. Primary data was obtained directly through interviews. While secondary data was obtained through observation and documentation. The results of this study indicate that the distribution of ZIS funds at the Indonesia Mulia Bekasi foundation has been effective and on target so that the funds can be allocated according to the needs of each program. In addition, the distribution of zakat funds has a significant impact in improving the welfare of mustahik, especially orphans and poor people.
Optimalisasi Peran Filantropi Islam Aksi Cepat Tanggap dalam Upaya Mengatasi Krisis Ekonomi di Era Pandemi Covid-19
Authors: Janah Wadzifatul
Published: January 2022

This study aims to determine the efforts and strategies of the Islamic philanthropic institution Aksi Cepat Tanggap (ACT) in overcoming the economic crisis in the current Covid-19 pandemic era. By optimizing the existing potential of ZISWAF to overcome problems of the ummah and humanity. Producing zakat and waqf assets, socializing the real ZISWAF, and collaborating with all existing philanthropic-based non-profit organizations. The research method used is qualitative descriptive, this research is a qualitative research with a type of case study (case study).
UPAYA MENUMBUHKAN JIWA INTRAPRENEUR SISWA MELALUI MATERI KEWIRAUSAHAAN DALAM PEMBELAJARAN ILMU PENGETAHUAN SOSIAL DI MTs SABILUL HUDA PONOROGO
Authors: Djuhan Muhammad Widda , Trianto Agus
Published: January 2022

This study aimed to determine the efforts to cultivate an intrapreneur spirit, the school's efforts to foster an intrapreneur spirit and the school's obstacles in cultivating an intrapreneur spirit. This type of research is a case study and the approach used by researchers is a qualitative approach. This research uses the research subjects of principals, teachers, students. Data collection techniques used in this study were: participatory observation, structured interviews and documentation. The analysis technique in this study uses data reduction, data presentation, drawing conclusions or verification. The results of this study there are still obstacles and obstacles in cultivating an intrapreneur spirit. Constraints that occur in the media and distribution of products that will be developed in entrepreneurial practice. so that it is still in the practice room and at the development stage. This discussion discusses the efforts of the teacher in processing the material, the efforts of the teacher. Student interest in class VII MTs Sabilul Huda, Karangjoho Village, Badegan District, Ponorogo Regency, there are learning problems with the enthusiasm of the students and the lack of enthusiasm for learning when implementing integrated social studies learning.
PESANTREN DALAM POLITIK DAN KEBIJAKAN PENDIDIKAN DI INDONESIA
Authors: Wathoni Kharisul
Published: January 2022

A political policy that is carried out within a certain period of time seems to encourage the development of a social system as an effort to maintain the security of the system and political policies. As the government policy given to pesantren as Islamic educational institutions in Indonesia, has had an impact on the development of Islamic education institutions in Indonesia from basic education institutions and even to the formation of higher education institutions that are able to compete with general education institutions. There are 5 characteristics inherent in Islamic boarding schools, namely: pondok, mosque, teaching of classical Islamic books, santri, and kyai. Islamic boarding schools in Indonesia have a very big role, both for the progress of Islam itself and for the Indonesian nation as a whole. Based on existing records, religious education activities in the archipelago have been started since 1596. These religious activities are later known as Islamic boarding schools. Ulama began to realize that the traditional Islamic boarding schools and education systems were no longer suited to the Indonesian climate at that time. Therefore, an idea emerged about the need to develop and renew Islamic education in Indonesia.
PENERAPAN PENDEKATAN SAINTIFIK DALAM PEMBELAJARAN PAI DI MASA PANDEMI COVID-19 DI SMAN 1 KURIPAN LOMBOK BARAT
Authors: Yuslih Muhammad , Paida Paida
Published: January 2022

This study aims to determine the application of a scientific approach in PAI learning for class X during the covid 19 pandemic. This type of research uses descriptive qualitative research by choosing a location at SMAN 1 Kuripan Dusun Tegal, Jagaraga Village, Kec. Kuripan, Kab. West Lombok. Sources of data in this study were PAI teachers and students of class X, the principal and the Deputy Head of Curriculum. The data collection method used is the method of observation, interviews, and documentation. The results showed that the application of a scientific approach to PAI learning in class X during the Covid-19 pandemic at SMAN 1 Kuripan used online and offline learning processes. In its implementation, through the first several stages, the teacher sends material in the form of videos or reading materials related to the material through WhatsAPP, then students observe the material. Second, ask about material that has not been understood either through Chat WA/Voice Chat. Third, associating/reasoning students are given tasks related to the material. Fourth, students present the assignment via WhatsApp. Fifth, students draw conclusions from the results of the presentation. The implementation of learning using a scientific approach in PAI learning during the COVID-19 pandemic has been carried out even though it has not been maximized. The obstacles in the application of the scientific approach include the lack of student activity in the learning process, and limited facilities and infrastructure.
Utilization of Instagram Social Media by Account @Tamanwisatagenilagit as A Promotion Media in Increasing Visitors 'Interest of Taman Geni Langit
Authors: Mafiroh Fauzia
Published: January 2022

Abstrak: Geni Langit Tourism Park is a tourist spot located in one of Magetan regencies. This tourist park offers natural scenery combined with photo spots that make this park visited by many tourists. From the description above, the researcher is interested in conducting research on the use of Instagram social media by Geni Langit Tourism Park. This study uses a descriptive type of research with a qualitative approach, namely by describing how the use of Instagram social media by the @tamanwisatagenilangit account in increasing visitor interest. Researchers got data from observations, interviews and documentation. From the research results, conclusions can be drawn: first, the use of Instagram social media by the @tamanwisatagenilangit account is to use several Instagram features, including (1) photo title or caption, (2) Hashtag, (3) Comments (4) Mentions (5) Geotag . Second, based on the results of observations and interviews with several visitors, Instagram social media is quite effective in increasing visitor interest. This is evidenced by the statement of visitors who know the many photo posts with the Instagramable concept from the @tamanwisatagenilangit account.
SOCIAL AWARENESS (Discourse Analysis of Novel Dalang Galau by Sujiwo Tejo)
Authors: Hamzah Adi Ari
Published: January 2022

Abstract: Sujiwo Tejo is an Indonesian novel writer who is considered a writer as well as a contemporary humanist. The themes in his novels always raise social, political or religious issues. The novel "Dalang Galau Ngetwit" is one of his works that raises social themes and brotherhood among religious communities, because these issues are realized increasingly fading with a variety of things that lie behind them. In the novel "Dalang Galau Ngetwit" Sujiwo Tedjo tries to give an understanding to the community about the importance of kinship without seeing what religion it adopts, helping one another and always living in harmony. In this novel's work, the writer sees social injustice in the text of Sujiwo Tejo's novel. To assess the work of the novel, the writer uses Teun A Van Dijk's Discourse Analysis which divides the discourse into three levels: macro structure, Superstructure and Microstructure. The problem formulated in this paper is, what is the meaning of the message conveyed by Sujiwo Tedjo through the novel "Dalang Galau Ngetwit" in seeing the social conditions of the community to religious harmony and how this novel is able to describe the attitude of the community in national and state activities towards the problem of changes that exist in the cultural conditions in Indonesia.
TEACHER'S CORPORAL PUNISHMENT TO STUDENTS AS LEARNING COMMUNICATION AT MAMBAUL HISAN CHILDREN'S ISLAMIC BOARDING SCHOOL PONOROGO
Authors: Choiroh Himatul , Marwantika Asna Istya
Published: January 2022

Learning communication is the process of delivering messages from teachers to students. One of the objectives of learning communication is to form a student's disciplinary attitude. The application of discipline sometimes requires corporal punishment as done in Mambaul Hisan Children’s Islamic Boarding School Ponorogo. The purpose of this research is to describe the form of corporal punishment of teachers in learning communication at Mambaul Hisan Children’s Islamic Boarding School Ponorogo. This research was conducted using descriptive research method with qualitative approach. Data collection techniques in this research are observations, interviews and documentation. Data analysis techniques using George Herbert Mead's symbolic interactionalism theory. The result of this study is the first, the application of corporal punishment in learning communication in Mambaul Hisan in the form of verbal and non verbal communication. Verbal communication is done by the teacher by warning students who make mistakes, nonverbal communication by giving corporal punishment such as being pinched, beaten, or tweaked. Second, the implication of corporal punishment given by teachers to students is a deterrent attitude and so as not repeating their mistakes.
HUBUNGAN PERHATIAN ORANG TUA TERHADAP PENINGKATAN MORAL ANAK
Authors: Hidayatus Ulfa , Prasetyo Budi Mayrina Eka
Published: January 2022

AbstractThis study aims to determine the level of parental attention to children aged 7-12 years in Durenan Village, Sidorejo Magetan District, for Knowing the level of moral development in children aged 7-12 years in Durenan Village, Sidorejo Magetan District, and to find out the relationship between parents' attention to improving the morale of children aged 7-12 years in Durenan Village, Sidorejo Magetan District. This study uses a quantitative approach with correlational research. The data collection technique uses questionnaire and observation techniques. The research data were analyzed using product moment correlation. The results showed the level of parental attention in the category moderate with a percentage of 87.5%, the level of moral development of children is in the medium category with a percentage of 78.13%, and there is a significant relationship between parental attention and moral improvement of children aged 7-12 years in Durenan Village, Sidorejo Magetan District. It is known from the results of calculations using the SPSs, namely the count of 0.929 and r table of 0.349, so that Ha accepted Ho is rejected, which means that there is a significant relationship between parental attention and moral improvement of children aged 7-12 years in Durenan Village, Sidorejo Magetan District.Keywords: parents' attention, children's moral improvement
PET BEREAVEMENT: MENGAJARKAN KONSEP DUKA PADA ANAK
Authors: Juliadilla Risa
Published: January 2022

Ketika anak berduka atas kematian hewan peliharaanya merupakan suatu keadaan yang rumit. Orang tua hendaknya tidak meremehkan keadaan tersebut namun juga tidak melebih-lebihkan. Sayangnya orang tua seringkali menghindari diskusi topik yang sulit salah satunya adalah kematian, makna kehilangan serta manifestasi emosi yang normal dari kesedihan anak. Padahal Pet Bereavment dapat dijadikan momen, orang tua  mengajarkan dengan perspektif lain misalnya menjelaskan pada anak bahwa kehidupan berdampingan dengan kematian, saat terdapat kematian maka juga ada kehidupan baru pada mahluk lain. Hal yang terpenting orang tua mengajarkan konsep kesedihan yang harus ditanggulangi dengan sehat agar anak dapat meneruskan hidupnya. Cara penjelasan mengenai kematian pada anak dapat mempengaruhi anak dalam melewati masa duka. Penjelasan yang tidak tepat berpotensi membuat bingung anak saat memahami konsep kematian. Melalui traditional review, artikel ini bertujuan agar orang tua memahami dan merespon dengan tepat reaksi duka sesuai usia anak serta mengajarkan proses berduka dan menanggulanginya.Kata Kunci:  Anak,  Pet Bereavement, Orang tua
MENELISIK REGULASI PENGGUNAAN TENAGA KERJA ASING (TKA) TERHADAP EKSISTENSI PEKERJA LOKAL DI INDONESIA DALAM PERSPEKTIF KEADILAN HUKUM
Authors: Mufidah Lailatul , Khasanah Uswatul , A’yun Qonita Qurrota
Published: January 2022

ABSTRAK: Pemerintah menerbitkan Peraturan Presiden No. 20 Tahun 2008 tentang Penggunaan Tenaga Kerja Asing (TKA) sebagai upaya untuk meningkatkan investasi, alih teknologi dan alih keahlian kepada pekerja lokal, serta perluasan kesempatan kerja. Oleh karena itu, investasi asing di Indonesia sepenuhnya ditujukan untuk meningkatkan kesejahteraan masyarakat. Namun, regulasi tersebut menimbulkan keresahan di masyarakat karena dinilai lebih memihak dan memudahkan masuknya pekerja asing. Hal ini dapat dilihat dalam Pasal 9, di mana izin menggunakan TKA tidak diperlukan lagi cukup dengan RPTKA. Selain itu, masih banyak TKA di Indonesia yang tidak memenuhi kualifikasi pendidikan dan keahlian sebagaimana diatur dalam Pasal 5, sehingga tujuan diundangkannya regulasi tersebut sebagai alih keahlian dan teknologi tidak benar-benar terjadi. Hal ini tentunya sangat bertentangan dengan prinsip keadilan hukum untuk menciptakan keadilan dan kesejahteraan masyarakat. Sanksi dan norma bagi pengguna TKA yang tidak sesuai dengan ketentuan perundang-undangan harusnya diterapkan, karena meningkatnya jumlah investor yang turut serta membawa pekerja kasar dari negara asalnya sangat kontradiktif dengan jumlah angkatan kerja di Indonesia yang terus meningkat setiap tahunnya.
EFEKTIFITAS PERMENDAG NO 24 TAHUN 2020 TENTANG PENETAPAN HARGA PEMBELIAN PEMERINTAH (HPP) UNTUK GABAH ATAU BERAS DALAM MENGHADAPI KRISIS PETANI DI INDONESIA
Authors: Pahlevi Farida Sekti
Published: January 2022

Indonesia adalah negara agraris yang sebagian besar masyarakatnya bermata pencaharian sebagai petani. Kebutuhan pangan menjadi hal yang diutamakan demi keberlangsungan hidup bangsa. Kesejahteraan petani dipengaruhi oleh kondisi petani dalam akses pasar dan keuntungan dari hasil panen. Kebijakan hukum pertanian hendaknya dapat memberikan perlindungan terhadap semua tantangan yang dihadapi oleh petani Indonesia khususnya terkait dengan harga hasil panen gabah atau beras. Potensi pertanian yang besar, hendaknya perlu adanya kebijakan pemerintah dalam mensejahterakan kehidupan petani dengan penetapan harga pembelian pemerintah hasil panen khususnya gabah atau beras. Setelah terbitnya permendag no 24 tahun 2020, ternyata masih ditemukan kekecewaan petani terhadap penetapan HPP tersebut. Tujuan dari jurnal ini yaitu, memaparkan efektifitas permendag nomor 24 tahun 2020 dalam menghadapi krisis petani di Indonesia. Adapun metode yang digunakan yaitu studi pustaka bersumber dari jurnal, peraturan-peraturan dan artikel yang berkaitan dengan kebijakan permendag nomor 24 tahun 2020. Hasil dari jurnal ini yaitu menunjukkan bahwa krisis petani di Indonesia terjadi karena adanya ketidakpuasan petani terhadap keuntungan yang didapatkan sehingga masyarakat khususnya generasi muda enggan memilih bermatapencaharian petani. Permendag no 24 tahun 2020 hadir menjadi salah satu bagian ikhtiar pemerintah dalam menjaga stabilitas harga gabah atau beras, akan tetapi belum efektif dalam mencegah krisis petani di Indonesia.
CHILDFREE PERSPEKTIF HAK REPRODUKSI PEREMPUAN DALAM ISLAM
Authors: Khasanah Uswatul , Ridho Muhammad Rosyid
Published: January 2022

Keputusan untuk childfree memunculkan stigma negatif dari masyarakat. Childfree dapat didefinisikan sebagai sebuah pandangan suami istri yang memutuskan untuk tidak mempunyai anak. Childfree bukanlah istilah baru, banyak pasangan suami istri di negara-negara besar yang memilih keputusan tersebut. Keputusan dalam memilih childfree dalam kehidupan rumah tangga tidak lepas dari peran suami istri. Hal ini karena menyangkut hak-hak reproduksi mereka. Hak reproduksi antara suami istri ini telah dibahas dalam Islam. Berangkat dari fenomena tersebut, maka penulis tertarik untuk melakukan penelitian dengan tujuan untuk menganalisis fenomena childfree dengan perspektif hak-hak reproduksi perempuan dalam Islam. penelitian ini dilakukan dengan metode penelitian yang digunakan dalam penelitian ini adalah kepustakaan (library research) dengan pendekatan yuridis normatif. Teknik pengumpulan data dengan dokumentasi serta dilakukan analisis dengan metode deskriptif dan isi (content analysis). Memutuskan untuk childfree haruslah dibarengi dengan pemikiran yang matang dan penuh kesadaran. Keputusan memilih childfree merupakan salah satu pengaplikasian dari hak reproduksi yaitu hak menolak kehamilan. Untuk mewujudkan hak tersebut, konsep relasi mitra antara suami dan istri haruslah diterapkan dalam sebuah rumah tangga. Keputusan dalam memilih untuk childfree harus dibarengi dengan diskusi antara suami istri. Dalam diskusi tersebut kedua pihak harus terbuka terutama pihak perempuan tentang alasan keputusan childfree itu dilakukan. Dalam memberikan alasan tersebut juga harus disertai alasan dasar yang kuat sehingga tidak merugikan kedua pihak.
Perumusan Kebijakan Pelayanan Pernikahan Selama Masa Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) Darurat
Authors: Sudartono Muhammad , Rachmandhani Muhammad Sulthon
Published: January 2022

Masa Pemberlakuan Pembatasan Kegiatan Masyarakat (PPKM) membuat seluruh aktivitas masyarakat kembali mengalami kelesuan. Begitu juga dengan kegiatan pelayanan masyarakat yang diselenggarakan oleh instansi pemerintah. Kantor Urusan Agama (KUA) sebagai ujung tombak pelayanan masyarakat dituntut untuk dapat memberikan pelayanan optimal di tengah rambu-rambu penerapan instruksi Direktur Jenderal Bimbingan Masyarakat Islam Nomor P-001/ DJ.III/Hk.007/07/2021.  Sehingga kebijakan yang dirumuskan oleh KUA dalam melayani pernikahan  merupakan kebijakan yang berorientasi untuk mendukung pemerintah dalam memutus rantai persebaran Covid-19. Oleh karena itu, penelitian ini bertujuan untuk menjelaskan proses perumusan kebijakan yang terdiri dari proses; perumusan k masalah, formulasi kebijakan yang terdiri dari; identifikasi kebijakan, penyusunan agenda kebijakan, membuat proposal kebijakan, dan pengesahan kebijakan. Metode penelitian yang digunakan adalah metode penelitian kualitatif berjenis studi kasus. Teknik pengumpulan data menggunakan wawancara, dokumentasi, dan observasi. Data dianalisis menggunakan teknik analisis Miles-Huberman. Hasil penelitian ini menunjukkan bahwa proses perumusan kebijakan  pelayanan pernikahan yang dilakukan oleh KUA selama masa PPKM telah melalui proses perumusan masalah, formulasi kebijakan yang terdiri dari identifikasi kebijakan, proses penyusunan agenda kebijakan, membuat proposal kebijakan, serta pengesahan kebijakan.
Implementasi Model Dan Desain Pembelajaran Daring Pada Anak Usia Dini Saat Pandemi Covid 19 di TK Perwanida Sooko Ponorogo
Authors: Mustofa Zamzam , Azizah Dica Nurul , Fitriyah Ruaidatul
Published: January 2022

Early Childhood Education is education at an early stage, in early childhood, children learn from those who cannot until they can. Of course, to teach children, teachers who are able to educate children well. As a good educator, he must have a learning model or design to support the teacher when teaching children. With this the purpose of this research is written to find out how to model and design good learning for children. Moreover, during a pandemic like this, the teacher must choose the appropriate and suitable learning model and design for children while studying at home. By using descriptive methods we can find out how an educator applies models and designs for early childhood. This research results that learning models and designs are very important for early childhood. learning models and designs such as role models or guidelines used by educators when carrying out learning activities for early childhood at school. If educators do not have a learning model or design that is suitable for early childhood, the teachers / educators will be confused about what kind of learning is appropriate and suitable for early childhood. As well as learning models and designs that are appropriate to use during a pandemic like this is to create a sense of comfort and safety even though they continue to carry out learning activities at home. Teachers / educators must prepare effective and efficient work programs so that they can improve the skills and intelligence of their students when studying at home.
Pengembangan Bahasa Anak Usia Dini Melalui Metode Bercerita Di Lembaga Paud Meraje Gune
Authors: Azhari Supian
Published: January 2022

Early Childhood Language Development Through Storytelling Method at Meraje Gune PAUD Institution. This paper will explore the methods used in learning to develop early childhood language skills at the Meraje Gune PAUD Institution. The focus of this research will be on how to develop language at an early age by using the storytelling method in improving language skills at an early age. The study uses descriptive qualitative research where one of the studies that describes the findings or results in the field, observes and analyzes what is in the research. The results of this study indicate that, early childhood language learning using methods that can develop the potential of early childhood language. In fact, the influence of learning methods in developing children's language skills is by opening access to improve children's language skills, seeing from starting to speak, never feeling shy in asking questions, being active in various fields, namely storytelling, singing and being a leader in class.
A Decision Support System to Enhance Electricity Grid Resilience against Flooding Disasters
Authors: Tavakol-Davani Hassan , Violante Michael , Manshadi Saeed
Published: January 2022

In different areas across the U.S., there are utility poles and other critical infrastructure that are vulnerable to flooding damage. The goal of this multidisciplinary research is to assess and minimize the probability of utility pole failure through conventional hydrological, hydrostatic, and geotechnical calculations embedded to a unique mixed-integer linear programming (MILP) optimization framework. Once the flow rates that cause utility pole overturn are determined, the most cost-efficient subterranean pipe network configuration can be created that will allow for flood waters to be redirected from vulnerable infrastructure elements. The optimization framework was simulated using the Julia scientific programming language, for which the JuMP interface and Gurobi solver package were employed to solve a minimum cost network flow objective function given the numerous decision variables and constraints across the network. We implemented our optimization framework in three different watersheds across the U.S. These watersheds are located near Whittier, NC; Leadville, CO; and London, AR. The implementation of a minimum cost network flow optimization model within these watersheds produced results demonstrating that the necessary amount of flood waters could be conveyed away from utility poles to prevent failure by flooding.
Hallux Valgus Recurrence After Simple Bunionectomy: Algorithm Treatment
Authors: Torrent Josep , Figa Raúl , Clares Iban , Rabat Eduard
Published: January 2022

Background: Recurrences of hallux valgus can be difficult to manage, especially after a prior simple bunionectomy. This study aimed to present a treatment algorithm for the correction of recurrences after a simple bunionectomy.Methods: This was a single-center, descriptive, and retrospective comparative study. Thirty-four consecutive patients were classified according to the bone stock and the presence or absence of end-stage arthritis of the first metatarsophalangeal joint (MTPJ). According to our algorithm, we only performed an osteotomy as the salvage procedure in cases with sufficient bone stock and absence of or mild arthritis. In the other cases, we performed an MTPJ fusion. Exceptionally, we chose a Keller-Brandes arthroplasty for patients with advanced age and comorbidities. Results: We performed 17 scarf osteotomies (50%), 15 MTPJ arthrodeses (44.1%), and 2 Keller-Brandes arthroplasties (5.9%). Following the algorithm, we achieved an improvement of the AOFAS score of >30 points without severe complications in all groups.Conclusions: The proposed operative algorithm successfully addresses the recurrences considering the lack of bone stock and the presence of MTPJ arthritis.Level of EvidenceLevel 3: retrospective comparative study
SARS-Cov-2 Infection in Postmenopausal Women. New Data on Menopause Hormone Therapy
Authors: Baquedano Laura , Navarro Javier , José Yasmina , Tristancho Alexander , Ruiz Ana , Rubio Patricia , Lamarca Marta
Published: January 2022

ObjectiveTo address the factors involved in hospital admission and medical follow up in postmenopausal women with COVID-19 diagnosis.MethodsRetrospective observational study. Postmenopausal women aged between 40-70 years since September 2020 until June 2021 with COVID-19 diagnosis were included. Of the 300 women cohort, 50 were receiving menopause hormone therapy (MHT)Results 288 patients were analyzed. The mean age was 56.20 years (+/-6.06y SD). Age (p=0.030), High blood pressure (HBP) (p=0.002), respiratory disorders (p=0.003), depression (p=0.028) and fibromyalgia (p=0.030) were associated with a greater risk for hospital admission, while MHT was found as a protective factor (p=0.042). Being a health professional (p<0.001), HBP (p=0.029), respiratory disorders (p=0.022), vitamin D deficiency (p=0.010), depression (p=0.005) and fibromyalgia (p=0.001) were related with a longer follow up while MHT was related with a shorter one (p=0.010). Regression analysis showed that HBP and respiratory disorders acted as independent factors for hospital admission while MHT and fibromyalgia were for the length of follow up. ConclusionsMHT has a positive impact in postmenopausal women with SARS-CoV-2 infection. HBP and respiratory disorders are associated with a higher risk of hospital admission of these patients.
First report of rapid, non-invasive, and reagent-free detection of malaria through the skin of patients with a beam of infrared light
Authors: Garcia Gabriela , Kariyawasam Tharanga , Lord Anton , Costa Cristiano , Chaves Lana , Lima-Junior Josué , Maciel-de-Freitas Rafael , Sikulu-Lord Maggy
Published: January 2022

We describe the first application of the Near-infrared spectroscopy (NIRS) technique to detect Plasmodium falciparum and P. vivax malaria parasites through the skin of malaria positive and negative human subjects. NIRS is a rapid, non-invasive and reagent free technique which involves rapid interaction of a beam of light with a biological sample to produce diagnostic signatures in seconds. We used a handheld, miniaturized spectrometer to shine NIRS light on the ear, arm and finger of P. falciparum (n=7) and P. vivax (n=20) positive people and malaria negative individuals (n=33) in a malaria endemic setting in Brazil. Supervised machine learning algorithms for predicting the presence of malaria were applied to predict malaria infection status in independent individuals (n=12). Separate machine learning algorithms for differentiating P. falciparum from P. vivax infected subjects were developed using spectra from the arm and ear of P. falciparum and P. vivax (n=108) and the resultant model predicted infection in spectra of their fingers (n=54).NIRS non-invasively detected malaria positive and negative individuals that were excluded from the model with 100% sensitivity, 83% specificity and 92% accuracy (n=12) with spectra collected from the arm. Moreover, NIRS also correctly differentiated P. vivax from P. falciparum positive individuals with a predictive accuracy of 93% (n=54). These findings are promising but further work on a larger scale is needed to address several gaps in knowledge and establish the full capacity of NIRS as a non-invasive diagnostic tool for malaria. It is recommended that the tool is further evaluated in multiple epidemiological and demographic settings where other factors such as age, mixed infection and skin colour can be incorporated into predictive algorithms to produce more robust models for universal diagnosis of malaria.
The feasibility of Telemedicine in Implementation of Therapeutic Hypothermia for Management of Neonatal Hypoxic-Ischemic Encephalopathy in Resource-Limited Areas.
Authors: Hadid Adnan , AL-Shantout Taher , Terkawi Rayan , Aldbes Baraa , Zahran Manal , Alsatouf Fadia , Najjar Hani , Mughrabieh MHD Hassan , Alhadid Nour , Altirkawi Khalid
Published: January 2022

Background: Telemedicine is widely used in neonatal services in developed countries. Lack of expertise and/or facilities, however, limited its use in developing countries and around areas of military conflicts. To our knowledge, no reports are demonstrating the feasibility of administering therapeutic hypothermia (TH) through telemedicine to neonates with hypoxic-ischemic encephalopathy (HIE) in resource-limited areas.Methodology: This is a retrospective study, evaluating 22 patients who received TH, guided by telemedicine, through a mobile app (Telegram®). We assessed the feasibility of utilizing Telemedicine in guiding the application of TH to infants affected with HIE in the North-West of Syria between July 2020 and July 2021.Results: Out of 5,545 newborn infants delivered during the study period, 22 patients were eligible for TH guided by Telemedicine. Patients were referred for consultation at a median (IQR) of 137 (35-165) minutes of life. A median (IQR) of 12 (3-18) minutes elapsed between the call for a consultation and the consultant response, and a median (IQR) of 30 (0-42) minutes elapsed between seeking the consultation and the initiation of cooling therapy. Eighteen patients completed cooling for 72 hours. The patients' temperatures were within the target range (33-34°C) most of the time (84.1%).Conclusion: Telemedicine is a feasible method to guide the implementation TH for HIE in resource-limited areas. The short-term success rate is relatively high; however, further studies with a larger population are needed to confirm these findings.
WITHDRAWN: Complete Genome Sequence of Unusual Strain of Zika Virus From West Africa
Authors: Gladysheva Anastasia V. , Svyatchenko Victor A. , Bayandin Roman B. , Shvalov Alexander N. , Ternovoi Vladimir A. , Loktev Valery B.
Published: January 2022

In 2018, a Zika infection was detected in patients in the Republic of Guinea. We determined the complete genome sequence of the Faranah/18 strain of Zika virus (ZIKV) isolated using C6/36 cells. The genome sequences are significantly different from those of other African ZIKVs. This isolate has 13 aa substitutions in nonstructural polypeptides, an additional glycosylation site on protein E, and unusual localization of MSI1 binding sites in the 3’-UTR of the African lineage. Additionally, Faranah/18 formed a separate lineage into African genotypes with divergence times near 94 and 646-861 years from Senegal and Uganda ZIKVs, respectively.
Comprehensive bioinformatic analysis of the expression and prognostic significance of TSC22D domain family genes in acute myeloid leukemia
Authors: Xu XiaoQiang , Jin Xin , Wang JiaXi , Sun Rui , Zhang Meng , Xiong Xia , Xie DanNi , Zhao MingFeng
Published: January 2022

Background: TSC22D domain family genes, including Tsc22d1-4, have been extensively reported to be involved in tumors. However, their expression profiles and prognostic significance in acute myeloid leukemia (AML) remain unknown. Methods: The present study investigated the expression profiles and prognostic significance of TSC22D domain family genes in AML through the use of multiple online databases, including the CCLE, EMBL-EBI, HPA, Oncomine,GEPIA2, UALCAN, BloodSpot, and GSCALite databases. The cBioPortal and GSCALite databases were used to explore the genetic alteration and copy number variation (CNV) of the Tsc22d3 gene. The TRRUST (Version 2) database was used to explore the gene ontology biological process, disease ontology, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways associated with the Tsc22d3 gene. The AnimalTFDB3.0, STRING, and Harmonizome databases were used to investigate the protein–protein interaction (PPI) network of the Tsc22d3 gene. The Harmonizome database was used for Tsc22d3 gene regulatory kinase analysis. The TargetScanHuman 7.2, MiRDB, and ENCORI databases were used to execute the analysis of the Tsc22d3 gene regulatory miRNAs. Then, the GSCALite and GEPIA2021 databases were used to investigate the correlation between Tsc22d3 expression and immune infiltration. Results: The expression of the Tsc22d3 gene was upregulated markedly in AML cells relative to normal hematopoietic stem cells. The expression of the Tsc22d3 gene was increased in AML tumor samples compared with healthy bone marrow samples. And overexpression of the Tsc22d3 gene was associated with poor OS in AML patients.This study implied that the Tsc22d3 gene is a new biomarker for predicting the prognosis of AML. Furthermore, gene ontology analysis showed that Tsc22d3 was involved in leukemia. Functional enrichment analysis showed that the Tsc22d3 gene has many biological functions, including the regulation of many genes, kinases, miRNAs, signaling pathways, and immune infiltration.Therefore, this study suggests that the Tsc22d3 gene may be a potential therapeutic target for AML. Conclusions: Tsc22d3 gene expression was upregulated in AML, and overexpression was associated with poor OS in AML patients. Therefore, the Tsc22d3 gene may serve as a novel prognostic biomarker and therapeutic target for AML.
Getting Human Resource Information Systems Right: A Case Presentation of Uganda
Authors: Arakelian Meghan , Brown Andrew N , Collins Alexandra , Gatt Leah , Hyde Sara , Oketcho Vincent , Olum Samson , Schurmann Anna , Siyam Amani
Published: January 2022

BackgroundHuman resources information systems (HRIS) are a key tool for collecting and analyzing health workforce data at the country level and the specific focus of milestones 4.1 and 4.2 of the Global Strategy on Human Resources for Health (HRH). Yet documentation on the capabilities of HRIS in low- and middle-income countries (LMICs) is limited. Vital Wave, with IntraHealth International and Cooper/Smith, conducted a targeted scan of the HRIS landscape in 20 countries and “deep-dive” assessments in Burkina Faso, Mozambique, and Uganda. Here we present the case of Uganda’s workforce information ecosystem. Case PresentationSince 2006, Uganda has seen investment in HRIS from different donors, overseen by the Ministry of Health (MOH) and accompanied by the rollout of IntraHealth’s open-source iHRIS software. Despite this history of investment, mapping of the country’s multiple information systems revealed uneven adoption and engagement nationally and sub-nationally, with high levels of data fragmentation due to lack of interoperability and data-sharing practices. We also mapped the administrative processes and data flows for three priority use cases: recruitment and deployment, salary payments, and performance management. What emerges is a complex, decentralized information ecosystem driven by years of donor investment, but one that still sees uneven ownership and data use across the health system. Challenges include:· Limited interoperability between systems, specifically payroll, iHRIS, and the district health information system (DHIS2)· Complex HRH planning and management policy context, with variable implementation of numerous policies and no single reference to guide investments and implementation· Limited visibility into the private and community health workforce. ConclusionsUganda’s progress in developing its HRH information ecosystem underscores the importance of continuously aligning system capabilities, incentives, and motivations to an ever-evolving country context. However, as evidenced in Uganda and our broader assessment findings, robustness of the information ecosystem itself is insufficient to making substantive strides toward the Global Strategy’s milestones 4.1 and 4.2—governance oversight and ownership are critical to success. With a better understanding of what good looks like in terms of HRIS functionality in LMICs and ensuring interventions are addressing the causal issues, there can be many pathways to making systems work.
Sorghum Agronomic Performance and Soil Chemical and Microbiological Properties as Influenced by Burkina Faso Phosphate Rock-Enriched Composts
Authors: Sagnon Adama , Iwasaki Shinya , Tibiri Ezechiel Bionimian , Zongo Nongma Armel , Compaore Emmanuel , Bonkoungou Isidore Juste O. , Nakamura Satoshi , Traore Mamadou , Barro Nicolas , Tiendrebeogo Fidele , Sarr Papa Saliou
Published: January 2022

Purpose The low availability of phosphorus (P) severely limits crop production in sub-Saharan Africa. We evaluated phosphate rock-enriched composts on soil properties and sorghum growth for use as environment-friendly fertilizers. Methods Treatments were sorghum straw, compost (Comp), Phosphate Rock (BPR), BPR-enriched compost (P-Comp), BPR-soil-enriched compost (P-Comp-Soil), nitrogen-phosphorus-potassium (NPK, 60-90-30), and control without phosphorus and organic material (CT). Sorgum straw and composts were applied at 1.34 tons ha-1. The amounts of nitrogen, phosphorus, and potassium in treatments, except in CT, were adjusted to 60, 90, 30 kg ha-1, with urea, BPR, and KCl, respectively. Sorghum vr. Kapelga was cultivated and soil samples were collected on days 52, 93, and 115 (harvest) for analysis. Results NPK and P-Comp-Soil provided the best sorghum yields. Soil available P was less in these treatments. P-Comp-Soil-amended soils recorded higher populations of bacteria (16S rRNA), acid phosphatase (aphA), phosphonatase (phnX), glucose dehydrogenase (gcd) and its cofactor pyrroloquinoline quinone (pqqE) genes. Phosphate-specific transporter (pstS) and arbuscular mycorrhizal fungi (AMF) abundances were generally higher in P-Comp-Soil soils, especially at the early growth stage. This active microbial activity in the P-Comp-Soil added to its initially higher available P justified a better nutrient uptake and yields comparable to NPK. Multivariate analysis also revealed the contribution of nitrogen, carbon, and exchangeable cations in sorghum growth. Conclusion This study demonstrated that direct phosphate rock application is not effective in sub-Saharan African upland cultivation. Alternative to chemical fertilizers, soils may be amended with phosphate rock-enriched composts, a niche of beneficial microbes improving soil health.
Impact of JAK Inhibitors in Pediatric Patients with STAT1 Gain-of-Function (GOF) Mutations – 10 Children and Review of the Literature
Authors: Deya Angela , Riviere Jaques Gabriel , Roxo-Junior Persio , Ramarkers Jan , Bloomfield Marketa , Hernandez Paloma Guisado , Lobo Pilar Blanco , Jamra Soraya Regina Abu , Esteve-Solé Ana , Kanderova Veronika , Garcia-Garcia Ana , Corbeto Mireia Lopez , Pomar Natalia Martinez , Nalda Andrea Martin , Alsina Laia , Neth Olaf , Olbrich Peter
Published: January 2022

Introduction. Since the first description of gain of function (GOF) mutations in Signal Transducer and Activator of Transcription (STAT) 1, more than 300 patients have been described with a broad clinical phenotype including infections and severe immune dysregulation. Whilst Jak inhibitors (JAKinibs) have demonstrated benefits in several reported cases, its indications, dosing and monitoring remain to be established. Methods. A retrospective, multicenter study recruiting pediatric patients with STAT1 GOF under JAKinib treatment was performed and, when applicable, compared with the available reports from the literature. Results. Ten children (median age 8.5y (3-18), receiving JAKinibs (ruxolitinib (n=9) and baricitinib (n=1)) with a median follow-up of 18m (2-42) from 6 inborn errors of immunity (IEI) reference centers were included. Clinical profile and JAKinib indications in our series were similar to the previously published 14 pediatric patients. 9/10 (our cohort) and 14/14 patients (previous reports) showed partial or complete responses. The median immune deficiency and dysregulation activity scores were 15.99 (5.2-40) pre and 7.55 (3-14.1) under therapy (p=0.0078). Infection, considered a likely adverse event of JAKinib therapy, was observed in 1/10 patient; JAKinibs were stopped in 3/10 children, due to hepatotoxicity, pre HSCT and absence of response. Conclusions. Our study supports the potentially beneficial use of JAKinibs in patients with STAT1 GOF, in line with previously published data. However, consensus regarding their indications and timing, dosing, treatment duration and monitoring, as well as defining biomarkers to monitor clinical and immunological responses, remains to be determined, in form of international prospective multicenter studies using established IEI registries.
Dynamics of optical vortices in 2D materials
Authors: Kurman Yaniv , Dahan Raphael , Sheinfux Hanan Herzig , Rosolen Gilles , Janzen Eli , Edgar James , Koppens Frank , Kaminer Ido
Published: January 2022

Optical vortices in planar geometries are a universal wave phenomenon, where electromagnetic waves possess topologically protected integer values of orbital angular momentum (OAM). The conservation of OAM governs their dynamics, including their rules of creation and annihilation. However, such dynamics remained so far beyond experimental reach. Here, we present a first observation of creation and annihilation of optical vortex pairs. The vortices conserve their combined OAM during pair creation/annihilation events and determine the field profile throughout their motion between these events. We utilize free electrons in an ultrafast transmission electron microscope to probe the vortices, which appear in the form of phonon polaritons in the 2D material hexagonal boron nitride. These results provide the first observation of optical vortices in any 2D material, which were predicted but never observed. Our findings promote future investigation of vortices in 2D materials and their use for chiral plasmonics, toward the control of selection rules in light-matter interactions and the creation of optical simulators of phase transitions in condensed matter physics.
Influenza Related Mortality in Populations That Fail to Reach Herd Immunity
Authors: Lanier Mary , Parkman Liliya , Quesada Jared
Published: January 2022

Background Vaccines remain an important public health tool to prevent morbidity and mortality. For influenza, this requires an annual vaccination strategy due to the need to reformulate the vaccine to target circulating strains. The annual success of such vaccine efforts on the annual mortality rates is important to understand and the focus of this study. Methods Data on vaccination rates and mortality associated with Influenza was obtained from the CDC Morbidity and Mortality Weekly Reports and STATS of the States. In addition, data searches were performed using the CDC WONDER database, local and county health reports, the World Health Organization, and United States census reports. Results Annual vaccination efforts have had minimal impact on the number of influenza related deaths for those over the age of 65. Additionally, herd immunity has not been achieved in any year at the state and national levels. A closer examination of the 2017 influenza season found that the most populous states had the highest mortality burden. However, there was no correlation in local population density and an increase in influenza mortality. Conclusion Deaths associated with Influenza circulating in largely populated states are going to occur where susceptible people are regardless of whether they live in rural counties or densely populated cities. Overall, we propose that to prevent annual deaths related to seasonal influenza, herd immunity must be reached in the most populous states. Targeted vaccination of only the susceptible populations is not enough to protect them from mortality associated with influenza.
Network Analysis for the Identification of Hub Genes and Related Molecules as Potential Biomarkers Associated With the Differentiation of Bone Marrow-derived Stem Cells Into Hepatocytes
Authors: Kwon Taeho , Han Ying-Hao , He Xin-Mei , Mao Ying-Ying , Liu Xuan-Chen , Sun Hu-Nan , Jin Mei-Hua , Lee Seung-Jae
Published: January 2022

The incidence of liver diseases has been increasing steadily. However, it has some shortcomings, such as high cost and organ donor scarcity. The application of stem cell research has brought new ideas for the treatment of liver diseases. Therefore, it is particularly important to clarify the molecular and regulatory mechanisms of differentiation of bone marrow-derived stem cells (BMSCs) into liver cells. Herein, we screened differentially expressed genes between hepatocytes and untreated BMSCs to identify the genes responsible for the differentiation of BMSCs into hepatocytes. GSE30419 gene microarray data of BMSCs and GSE72088 gene microarray data of primary hepatocytes were obtained from the Gene Expression Omnibus database. Transcriptome Analysis Console software showed that 1896 genes were upregulated and 2506 were downregulated in hepatocytes as compared with BMSCs. Hub genes were analyzed using the STRING, revealing that two hub genes, Cat and Cyp2e1, play a pivotal role in oxidation-reduction process. The results indicate that the lncRNA-miRNA-mRNA interaction chain may play an important role in the differentiation of BMSCs into hepatocytes, which provides a new therapeutic target for liver disease treatment.