bluuebunny/crossref_metadata_2025 huggingface dataset:
Efektifitas Penambahan Source to Image Distance (SID) terhadap Penurunan Dosis Radiasi pada Pemeriksaan Radiografi Cranium
Authors: Bequet Angga Yosainto , Nurcahyo Panji Wibowo , Sulistiyadi Akhmad Haris
Published: December 2022

Background: Cranial radiographs are routinely made in 2 projections, namely Antero Posterior (AP) and Lateral with a minimum distance of 100 cm from the radiation source to the image receptor. In addition, it has been shown that increasing the SID from 40 to 48 inches reduces the skin dose even when the requirement for an increase in mAs is considered. A 44-inch or 48-inch SID is recommended where departmental equipment and protocols allow. This study aims to determine the effectiveness of the addition of SID to decrease the radiation dose on cranium radiographs.Methods: This type of research is a pre-experimental quantitative. The study was conducted at the radiology laboratory of Diploma Three Program of Radiology Purwokerto, Semarang Health Politechnic of Ministry of Health. The research subject is a Radiographic Xray Cranial Phantom. At the time of exposure, the radiation dose was measured and the resulting image was measured CNR value.Results: The results of radiation dose measurements at each SID setting for AP cranium radiographs are shown in the table above. setting SID 100 cm produces a radiation dose of 5.58 mSv, SID 110 cm produces a radiation dose of 5.16 mSv, SID 120 cm produces a radiation dose of 5.02 mSv, SID 130 cm produces a radiation dose of 4.84 mSv, SID 140 cm produces a radiation dose of 4.64 mSv and SID 150 cm produces a radiation dose of 4.36 mSv. There are differences in radiation dose values between SID settings of 100 cm, 110 cm, 120 cm, 130 cm, 140 cm and 150 cm with a statistical test p-value 0.001. The results of statistical tests on the Contrast to Noise Ratio value on changes in the SID value of the AP cranium radiography examination showed no significant difference. The p-value of the statistical test is 0.274 which means there is no difference in the CNR value between the SID settings of 100 cm, 110 cm, 120 cm, 130 cm, 140 cm and 150 cm.Conclusions: An increase in SID causes a decrease in radiation dose. The increase in SID did not cause a significant difference to the quality of the Contrast to Noise Ratio on the AP cranium radiograph image.
MICROBIOLOGICAL STUDY OF THE ANTHROPOGENIC PRESSURE ON THE YANTRA RIVER IN THE REGION OF VELIKO TARNOVO
Authors: Tsvetanova Zvezdimira , Dimitrov Dimitar , Naidenski Hristo
Published: December 2022

The report discusses the microbiological status of the Yantra River in the region of the town of Veliko Tarnovo. Water samples collected at 11 points of the river stretch were analyzed for quantification of E. coli and coliforms, intestinal enterococci and heterotrophic bacteria. It was found increased levels of fecal indicator bacteria in the river waters, varying over time and along the riverside. The number of viable E. coli and enterococci increased under the influence of untreated wastewater influx and the Belitsa River.
A THEORETICAL OVERVIEW OF COMPRESSED AIR ENERGY STORAGE TECHNOLOGIES AND DEVELOPMENTS
Authors: Bakhtiari Leila , Karamanev Dimitre
Published: December 2022

In our modern world, technological developments on the one hand, and global warming and its consequences, on the other hand, cause us to feel the necessity for reliable, cost-effective, and clean energy. Using renewable energy sources paired with compressed air energy storage can be a good option that meets these expected criteria. Although a compressed air energy storage system (CAES) is clean and relatively cost-effective with long service life, the currently operating plants are still struggling with their low round trip efficiencies. This paper illustrates an up-to-date review of compressed air energy storage systems containing changes in the conventional process to improve performance and increase efficiency. Three main categories of compressed air energy storage technology, diabatic, adiabatic, and isothermal, are analyzed theoretically. In addition, three components of a compressed air energy storage system including compression system, reservoirs, and expansion system are discussed here in detail. The advantages, disadvantages, and the technological readiness of different types of CAES are discussed.
The Noisy Silence of villagers with Deafness of Dhadkai, Jammu, India: A Case Study
Authors: Kathuria Dr. Sunita Joshi , Sharma Saroj
Published: December 2022

The Indian National Education Policy (NEP), 2020 clearly stated that the disparity and gaps due to gender, culture, literacy, geographical area and economic conditions need to be bridged up in India. And, for this Socio-Economically Disadvantaged Groups (SEDGs) must be identified and mainstreamed with the system. In addition to that, NEP is also in complete consonance with the Rights of Persons with Disabilities Act of India (RPwD, 2016), which places a strong emphasis on the inclusion and equal participation of individuals with disabilities. With this as a starting point, the researchers set out to investigate and research one of the minority populations, with a special focus on people with disabilities. On exploring the existing literature, the researchers found 3 villages in India with a high prevalence of specific disability i.e. ‘deafness’. To study the existing situation and experiences in detail, one of the villages named _Dhadkai_ was selected as a case study. Understanding the ecological and socio-cultural environment of the inhabitants of Dhadkai village was one of the study's main objectives. Another was to investigate the challenges faced by the people of Dhadkai, particularly of villagers with deafness and with regard to access to education. The people of Dhadkai village were the population of this study and volunteer sampling method was used for the sample selection. The researchers administered interviews, direct observations and maintained a researcher’s diary to gather the data. 36 people with deafness, including 13 women and 23 men, were interviewed and observed. In order to learn more about the socio-cultural context of the village, 15 persons with hearing sensitivity were also made the part of the sample. Hence, 45 people were taken as a sample in the study. By using a thematic analysis technique, themes were generated and reported in the finding section. The findings of the research revealed hereditary as the main cause of deafness among the villagers and highlighted the struggle of many families who have been struggling hard to earn even their daily living. In addition to poor economic conditions, the people with deafness in this village had never been to any academic institution in their life. Moreover, no provision of catering to educational and vocational needs of individuals with hearing loss was observed. This demonstrated how ignorance of the system and a lack of resources have inhibited this population from realizing their dreams. With respect to their communication skills, the people (with deafness) of Dhadkai use local sign language and have a very limited vocabulary. Through this paper, the authors submit their suggestions and present the scope of interventions which can be made independently and in collaboration with different ministries and non-governmental organizations. The villagers have high expectations and hope from the Government of India and dream to observe development in the village for the benefit of the villagers, society and the nation.
Risk-oriented approaches to the justification of shelf life flour products
Authors:   Ural State University of Economics, Bortsova E.L. , Lavrova L.Y. ,   Ural State University of Economics
Published: December 2022

Improvement of technological processes entails the need to revise the shelf life and identify possible risks. Using the example of frozen condensed milk pancakes, risks were identified and a hazard analysis was conducted for safety indicators at all stages of the technological process. Preventive measures regulated by the HACCP system have been developed. The effectiveness of the measures was evaluated, which was confirmed by laboratory studies with the justification of shelf life. A program of confirmation of shelf life was drawn up when determining shelf life for 20 days with a reserve factor of 1.3, according to which laboratory studies of frozen pancakes with condensed milk were carried out according to physical and chemical quality parameters. Chemical and biological risks were investigated when confirming the shelf life of this flour product. The results obtained indicate the effective organization of incoming control and mandatory preventive measures.
UJI AKTIVITAS ANTIBAKTERI EKSTRAK PROPOLIS LEBAH Heterotrigona itama DARI BEBERAPA LOKASI BUDIDAYA DI KALIMANTAN TIMUR TERHADAP BAKTERI Propionibacterium acnes
Authors: Arung Enos Tangke , Dikarulin Sarah Azzara , Dewi Listyaningrum Dyah Ayu , Ananda Bayu Susetya , Putri Tasya Ananda , Amirta Rudianto , Rosamah Enih , Suwinarti Wiwin , Yuliansyah Yuliansyah , Kusuma Irawan Wijaya , Ramadhan Rico
Published: December 2022

Propolis merupakan produk penting bagi lebah yang banyak digunakan sebagai salah satu alternatif pengobatan alami karena mengandung senyawa bioaktif yang dapat memberikan efek positif pada tubuh. Sebagai produk yang dihasilkan lebah untuk menutupi sarangnya dan mencegah predator maupun infeksi bakteri atau virus dari luar, propolis memiliki salah satu manfaat sebagai antibakteri. Penelitian ini bertujuan untuk mengetahui daya hambat ekstrak propolis lebah Heterotrigona itama yang berasal dari 4 lokasi budidaya (perkebunan, persawahan, hutan sekunder, dan perkotaan) di Kalimantan Timur terhadap bakteri Propionibacterium acnes atau P.acnes dengan metode difusi lubang/sumuran pada media nutrient broth (NB) dengan kloramfenikol sebagai kontrol positif dan aseton sebagai kontrol negatif. Propolis diekstrak menggunakan metode maserasi dengan larutan etanol 96% yang kemudian dibuat dalam 3 (tiga) konsentrasi yaitu 500ppm, 250 ppm, dan 125 ppm. Hasil penelitian menunjukanfitokimia dari propolis di 4 lokasi budidaya dominan mengandung alkaloid, flavonoid dan kumarin. Uji bakteri pada konsentrasi 500 ppm,propolis H.itama dari lokasi perkebunan dan persawahan tergolong dalam kategori kuat dalam menghambat pertumbuhan bakteri, dari lokasi hutan sekunder tergolong sedang, dan dari lokasi perkotaan tergolong rendah.
Gondolatok az egyes speciális börtönszabályok tárgyában nemzetközi kitekintéssel
Authors: Kovács István
Published: December 2022

A tanulmányban három kérdéskört járok körül, amely az európai büntetés-végrehajtási rendszereket jellemzi. A tanulmányban egy uniós és schengeni, egy uniós, de nem schengeni, valamint egy sem nem schengeni sem nem uniós országot elemzek. Az összehasonlító elemzés középpontjában a büntetés-végrehajtási rendszerben a tényleges életfogytig tartó szabadságvesztés kiszabása, a törvényességi felügyelet valamint az édesanya és a gyermek elhelyezésére szolgáló speciális szabályok vizsgálata áll. Az országválasztás indokát az a körülmény alapozta meg, hogy vajon a nemzetközi kötelezettségvállalás miként befolyásolja a vizsgált speciális szabályokat a különböző országokban.
Sport és tudomány – ez aztán a teljesítmény!
Authors: Molnár Katalin
Published: December 2022

A recenzió Mácsár Gábornak a 100 éves magyar rendőrség sportsikereit tartalmazó, Magyar Rendőr Sportalmanach című könyvéről szól.
A reintegrációs őrizet garanciaelemei
Authors: Bogotyán Róbert
Published: December 2022

A reintegrációs őrizet mint a büntetések, az intézkedések és a szabálysértési elzárás végrehajtásáról szóló 2013. évi CCXL. törvény (Bv. tv.) egyik jelentős nóvuma, több mint hat éve tölti be küldetését a hazai reintegráció platformján. A jogintézmény részben külföldi példákon, nagyrészt pedig a magyar rendőrség által is eredményesen, az elektronikus távfelügyeleti eszközökkel végrehajtott bűnügyi felügyeleten alapszik.2 Eredményességének titka számos tényező mellett abban is gyökeredzik, hogy szoros együttműködést követel és követelt meg az illetékes büntetés-végrehajtási és rendőrségi szakemberek között. A rendszer a fizikai kontrollfunkció és a helymeghatározási technológiák töretlen fejlődésén alapszik, aminek segítségével ma már a rendvédelemben is elérhetővé váltak azon eszközök, amelyek folyamatos távfelügyeleti lehetőséget biztosítanak az érintett személy (jelen esetben a szabadságvesztésre ítélt fogvatartott) felett.
A Review of Bone Cements as Injectable Materials for Treatment of Bone-Related Diseases: Current Status and Future Developments
Authors:   Independent Researcher., Hosseini Saeideh
Published: December 2022

Increasing the average age of the population as well as sports injuries, bone-related diseases, such as osteoporosis, rupture or damage to cartilage and bone tissues, and bone fractures, has dramatically increased the need for repair and joint replacement surgeries. Biocompatible materials that are used as prosthetic stabilizers and bone fillers in orthopedic surgery are known as injectable bone cement (IBCs). Available clinical IBCs, such as polymethyl methacrylate and calcium phosphate cement are the most important of these materials. This paper presents the most popular substances for medical use. Although this replacement procedure reduces the pain and restores joint function, it is associated with several drawbacks that limit its efficiency and effectiveness, and sometimes patients should undergo revision surgeries. Recently, the development of the next generation of IBCs, which are bioactive and degradable with good mechanical properties, is of great interest. For the long-term clinical performance in cement arthroplasty, the next generation of bone cement with far greater mechanical and biological properties than acrylic bone cement on the market is required. As a result, new approaches and formulas have been developed using various techniques from different disciplines. This study summarizes the challenges, developments, and recommendations for the future. For this purpose, various literature from databases, such as ScienceDirect, SpringerLink, PubMed, and so on were consulted from 2000 to 2020.
АНАЛІЗ ДАНИХ СИСТЕМАТИЧНИХ ОГЛЯДІВ ТА МЕТА-АНАЛІЗІВ ЩОДО УСПІШНОСТІ ЗАСТОСУВАННЯ НЕПРЯМИХ КОМПОЗИТНИХ РЕСТАВРАЦІЙ У СТОМАТОЛОГІЧНІЙ ПРАКТИЦІ
Authors: ГОНЧАРУК-ХОМИН Мирослав , ГОРЗОВ Людмила , БІЛИЩУК Любов , ВОЙТОВИЧ Вікторія , МЕЛЬНИК Леся
Published: December 2022

Анотація. Вступ. Прогноз успішності терапевтичного лікування дефектів твердих тканин зубів залежить від впливу низки факторів, серед яких можна виокремити такі, що пов’язані із досвідом лікаря-стоматолога, специфікою клінічної ситуації, специфікою технології відновлення/реставрації та власне типом вибраної реставрації. Мета дослідження – проаналізувати показники успішності застосування непрямих композитних реставрацій за даними систематичних оглядів та досліджень мета-аналітичного характеру та порівняти їх з показниками успішності функціонування прямих композитних реставрацій та часткових керамічних реставрацій. Матеріали та методи. Дослідження було організоване у формі ретроспективного аналізу даних систематичних оглядів та наукових робіт мета-аналітичного характеру. Формування первинної когорти публікацій проводилося з кількості таких, що наявні у базі даних PubMed (https://pubmed.ncbi.nlm.nih.gov/), в процесі пошуку з використанням відповідних Mesh-термінів. Результати дослідження та їх обговорення. У результаті проведеного опрацювання даних систематичних оглядів та мета-аналізів не вдалось верифікувати доказово підтвердженої різниці щодо успішності функціонування прямих та непрямих композитних реставрацій, що може бути аргументовано гетерогенністю дизайнів проаналізованих досліджень, відмінностями клінічних умов, у разі яких використовувались різні типи конструкцій, та критеріїв, які застосовувались для оцінки функціонального стану таких. Висновки. Лише окремі докази низького та середнього рівнів якості, отримані в ході опрацювання даних систематичних оглядів та мета-аналізів, свідчать про вищий рівень успішності функціонування непрямих композитних реставрацій порівняно із прямими за аналогічної тривалості експлуатації конструкцій. Статистично підтвердженої різниці успішності функціонування прямих та непрямих композитних реставрацій, що базується на доказах високого рівня якості, ідентифікувати не вдалось. У короткостроковій перспективі непрямі часткові керамічні реставрації характеризуються вищим рівнем успішності функціонування порівняно із непрямими композитними конструкціями в аналізі таких відносно аналогічного дизайну.
ОСОБЛИВОСТІ СИНДРОМУ ВЗАЄМООБТЯЖЕННЯ ЗА КОМОРБІДНОСТІ ПЕПТИЧНОЇ ВИРАЗКИ ШЛУНКА, ДПК ТА ЗАХВОРЮВАНЬ ТКАНИН ПАРОДОНТУ У ОСІБ ІЗ НЕЗНІМНИМИ ЗУБНИМИ ПРОТЕЗАМИ
Authors: РОЩУК Олександра , ГАВАЛЕШКО Василь , ХУХЛІНА Оксана
Published: December 2022

Анотація. Коморбідний перебіг пептичної виразки шлунка, дванадцятипалої кишки та захворювань тканин пародонту свідчить про спільні патогенетичні механізми їх розвитку та прогресування. Однак дослідники не завжди враховують наявність зубних протезів, у тому числі незнімних, виготовлених з різних матеріалів, на перебіг цих захворювань. Мета статті – дослідити особливості клінічного перебігу захворювань пародонту у хворих на пептичну виразку за наявності зубного протезування та без нього. Для вирішення поставленої мети та завдань проведено дослідження стану тканин пародонту у 177 хворих на пептичну виразку, яких було поділено на 4 групи залежно від наявності зубних протезів та їх конструкційного матеріалу: 1 групу становили 43 особи без зубних протезів, 2 групу становили 65 осіб, які мали незнімні металеві зубні протези: штамповано-паяні та суцільнолиті конструкції, 3 групу – 42 пацієнти із незнімними металокерамічними зубними протезами та 4 групу – 27 осіб із незнімними керамічними зубними протезами. Групу контролю становили 20 практично здорових осіб відповідного віку. Статистичну обробку матеріалу проводили із використанням сучасних методів варіаційної статистики. Встановлено, що поширеність захворювання пародонту у хворих на пептичну виразку шлунка та дванадцятипалої кишки без зубного протезування та за наявності незнімних протезів відрізнялася на 13,8% (p<0,05). Серед груп пацієнтів із незнімними зубними протезами найвищі показники поширеності хронічного генералізованого пародонтиту І та ІІ ступенів тяжкості виявлено в групі пацієнтів із незнімними металевими зубними протезами (у 60,0% та 29,2 % осіб відповідно), що в 1,6 раза та 2,6 раза відповідно було вищим за показники у хворих із незнімними керамічними протезами (p<0,05). Наявність металовмісних зубних протезів у ротовій порожнині також несприятливо впливала на перебіг пептичної виразки шлунка та ДПК, оскільки сприяла розвитку виразкових дефектів більшого розміру, ніж у групі без зубних протезів (р<0,05).
PENGARUH PERTUMBUHAN PENJUALAN DAN LIKUDITAS TERHADAP PROFITABILITAS (Studi pada Perusahaan Pertambangan Subsektor Batu Bara yang Terdaftar di BEI Periode 2017-2020)
Authors: Rosyanti Novi , Ramadhanthi Resti Jayeng , Firman Iman
Published: December 2022

Tujuan dari penulisan ini adalah untuk menguji pengaruh pertumbuhan penjualan dan likuiditas terhadap profitabilitas pada Perusahaan Pertambangan Sub Sector Pertambangan Batu Bara yang terdaftar di Bursa Efek Indonesia Periode 2017-2020. Populasi yang digunakan dalam penelitian ini adalah perusahaan pertambangan sub sector batu bara, dengan sampel penelitian sebanyak 19 Perusahaan pertambangan batu bara. Teknik sampel yang digunakan yaitu Purposive sampling. Jenis data yang digunakan dalam penelitian ini adalah dara kuantitatif dengan data sekunder yaitu laporan keuangan tahunan perusahaan yang telah dipublikasikan di website perusahaan masing-masing sesuai dengan daftar perusahaan yang terdaftar di Bursa Efek Indonesia dengan Periode 2017-2020. Teknik analisis data menggunakan analisis multivariate dependensi menggunakan regresi linier berganda. Hasil dari penelitian ini menunjukan bahwa dengan melalui uji parsial (Uji t) diperoleh hasil bahwa pertumbuhan penjualan memiliki nilai signifikansi 0,337 dengan nilai koefisien sebesar – 131 yang berati bahwa pertumbuhan penjualan tidak berpengaruh terhadap profitabilitas yang diperhitungkan menggunakan rasio Return On Assets. Likuiditas yang diperhitungkan dengan Current Ratio melalui pengujian parsial (Uji t) menunjukan hasil nilai signifikansi sebesar 0,041 dengan koefisien sebesar 0,239, hal ini mengartikan bahwa Likuiditas berpengaruh positif dan signifikan terhadap profitabilitas perusahaan yang diperhitungkan menggunakan rasio Return On Assets

Kata Kunci: Pertumbuhan Penjualan, Likuiditas, Profitabilitas, Perusahaan pertambangan
Comparative Analysis between Elgamal and NTRU Algorithms and their implementation of Digital Signature for Electronic Certificat
Authors: Harjito Bambang , Setyawati Tri , Wijayanto Ardhi
Published: December 2022

The emergence of electronic certificates, which are official documents in the form of digital files transmitted via the internet, facilitates the exchange of information. However, internet use has risks, such as data theft for fabricating and modifying information. This problem can be solved by applying a digital signature. This problem can be solved by applying a digital signature. The main concern in this research is how to perform a comparative analysis between asymmetric cryptographic Elgamal and NTRU (Nth-Degree Truncated Polynomial Ring) algorithms and their implementation of a digital signature as an effort to improve information security in electronic certificates. The stages of the research method are divided into the key generation process, signing, and verification. In the signing and verification process, the SHA-512 hash function is also used for hashing messages to be encrypted-decrypted and QR Code as the signature. Comparison of performance of NTRU with Elgamal algorithms required running at a pdf extension with security levels 80,128,192, 256 bits will be obtained from the templates.office.com website. The results obtained that the El Gamal algorithm is better than the NTRU algorithm, but at a higher security level, the NTRU algorithm is better than the Elgamal algorithm. In the verification experiment that has been carried out, it can be concluded that by using SHA-512 as a hash function, the N parameter used for NTRU must be greater than or equal to 512 to avoid error results from verification.
Adipocytes control hematopoiesis and inflammation through CD40 signaling
Authors: Reiche Myrthe E. , Poels Kikkie , Bosmans Laura A. , Vos Winnie G. , Van Tiel Claudia M. , Gijbels Marion J.J. , Aarts Suzanne A.B.M. , Den Toom Myrthe , Beckers Linda , Weber Christian , Atzler Dorothee , Rensen Patrick C.N. , Kooijman Sander , Lutgens Esther
Published: December 2022

The co-stimulatory CD40-CD40L dyad plays an important role in chronic inflammatory diseases associated with aging. Although CD40 is mainly expressed by immune cells, CD40 is also present on adipocytes. We aimed to delineate the role of adipocyte CD40 in the aging hematopoietic system and evaluated the effects of adipocyte CD40 deficiency on cardiometabolic diseases. Adult adipocyte CD40-deficient mice (AdiCD40KO) mice had a decrease in bone marrow hematopoietic stem cells (Lin–Sca+cKit+, LSK) and common lymphoid progenitors, which was associated with increased bone marrow adiposity and T-cell activation, along with elevated plasma corticosterone levels, a phenotype that became more pronounced with age. Atherosclerotic AdiCD40koApoE–/– (CD40AKO) mice also displayed changes in the LSK population, showing increased myeloid and lymphoid multipotent progenitors, and augmented corticosterone levels. Increased T-cell activation could be observed in bone marrow, spleen, and adipose tissue, while the numbers of B cells were decreased. Although atherosclerosis was reduced in CD40AKO mice, plaques contained more activated T cells and larger necrotic cores. Analysis of peripheral adipose tissue in a diet-induced model of obesity revealed that obese AdiCD40KO mice had increased T-cell activation in adipose tissue and lymphoid organs, but decreased weight gain and improved insulin sensitivity, along with increased fat oxidation. In conclusion, adipocyte CD40 plays an important role in maintaining immune cell homeostasis in bone marrow during aging and chronic inflammatory diseases, particularly of the lymphoid populations. Although adipocyte CD40 deficiency reduces atherosclerosis burden and ameliorates diet-induced obesity, the accompanying T-cell activation may eventually aggravate cardiometabolic diseases.
Gamificación en la enseñanza de las matemáticas en niños con trastornos por déficit de atención e hiperactividad
Authors: Espinales Marín Johanna Vanessa , Muñoz Pérez Rubén , Garcés Acosta Juan Pablo
Published: December 2022

Introducción: es escasa la disponibilidad de estudios referente a la enseñanza de las matemáticas mediante la gamificación en alumnos con Trastorno por Déficit de Atención e Hiperactividad. La presente investigación plantea la revisión bibliográfica de la gamificación como herramienta de enseñanza en las matemáticas con niños que presentan Trastornos por Déficit de Atención e Hiperactividad, exteriorizando la contribución dentro del salón de clases. Objetivos: el objetivo general de este trabajo es identificar la contribución de la gamificación en la enseñanza de las matemáticas en niños con TDAH de la educación básica desde la revisión de publicaciones científicas desde 2010 - 2022. Metodología: la metodología utilizada está centrada en el metaanálisis de 58 artículos científicos encontrados en diferentes bases de datos como Academia, Base, Dialnet, Scielo, Redib, Teseo, Scopus, Redalyc, entre otras. De la misma forma se muestra un análisis hermenéutico respecto a los siguientes constructos: Gamificación en el ámbito formativo; Enseñanza gamificada de las matemáticas en estudiantes de educación básica; El Trastorno por Déficit de Atención e Hiperactividad (TDAH) en el entorno educativo. Resultados: los resultados de esta investigación están enfocados en identificar la contribución de la gamificación en la enseñanza de las matemáticas en los niños con TDAH. Conclusiones: finalmente se muestran las conclusiones donde se expresa que la gamificación en la enseñanza de niños con TDAH ha logrado progresos fructíferos en su aprendizaje, mejorando su motivación, concentración, despertando el interés, convirtiéndose en una herramienta atractiva para el docente, contribuyendo en gran medida al beneficio del aprendizaje, ya que brinda oportunidades que mejoren en cierto punto su rendimiento académico. Área de estudio: Ciencias de la Educación Básica.
Law and the Metaethics of Discord
Authors: Vogt Katja
Published: December 2022

Plato’s Euthyphro, I argue, lays out a metaethics that responds to persistent and unresolved value disagreement. The dialogue’s analysis of disagreement leads to the distinction between three kinds of value, exemplified by the good, the god-loved, and the pious. With this proposal, I reject centuries of scholarship, which ascribe a realist metaethics to the Plato of the Euthyphro. But only the good and the just require a ‘realist’ analysis: we relate to them as features of the world to which we have attitudes, not as features of the world that are conferred by our attitudes. The god-loved is overtly attitudinal, thus calling for an anti-realist account. A compelling account of the pious has both realist and anti-realist dimensions. All three kinds of value, I argue, are to be found in the domain of law. Here, too, the good and the just require a realist, the legal an anti-realist, and the lawful a realist and anti-realist analysis. As important as piety was for millennia, it is a non-issue in today’s metaethics. But its analogue in the domain of the law, the lawful, plays a crucial role in our lives today. While we recognize legality as potentially flawed, respect for the law is an indispensable attitude if we are to strive towards improved lives and improved societies.
Virtue and the Normativity of Law
Authors: Amaya Amalia
Published: December 2022

This paper examines the normativity of law, that is, law’s capacity to guide behavior by generating reasons for action, from the perspective of virtue jurisprudence. It articulates a virtue-based model of law’s normativity according to which the law generates first order reasons for action (that is, loyalty-reasons) that need to be factored in citizens’ and legal officials’ practical reasoning, which consists, primarily, in the search for the best specification of the values involved in light of an account of the good life and the role that the law plays wherein. The outcome of this piece of practical reasoning is a judgment about what ought to be done, the rightness of which depends, on the proposed model, on whether it is a judgment that a virtuous person would characteristically do in the circumstances. This model, it is argued, has distinctive features that set it apart from some prominent accounts of the normativity of law. It may, however, be disqualified as a plausible alternative account of the normativity of law on the grounds that it fails to provide action-guidance. The last part of the paper responds to this objection in a way that unveils the relevance of the social dimensions of virtue to law’s normativity.
Removal of
brilliant green dye from wastewater using activated chickpea husk as an
adsorbent
Authors: Rani Sonia , Chaudhary Sudesh
Published: December 2022

A novel adsorbent was developed from chickpea husk and its powder form was used for elimination of brilliant green dye from wastewater. Activated carbon from chickpea husk has been prepared and distinguished with a Scanning electron microscope, Brunauer-Emmett-Teller surface area analyser and a Fourier transform infrared spectroscope. Different variables, like contact time of adsorbent and adsorbate, adsorbent amount, initial concentration of dye and pH were studied to perceive their effect on adsorption of dye. The elimination percentage of brilliant green dye by using chickpea husk was found to be 90.3 % in 150 min at a concentration of 20 mg/l and pH = 7 when a dose of 0.1 g was used. Adsorption kinetics was verified by pseudo 1st order and pseudo 2nd order. It was observed that rate of adsorption of brilliant green dye follows pseudo 2nd order model. Experimental equilibrium study was discussed using Langmuir and Freundlich isotherms models and it was observed that the Freundlich adsorption isotherm model was well fitted for the adsorption of brilliant green dye.
Determination of particulate matter fractions pm2.5, pm10 and co2 in urban schools in Imphal, India
Authors: Khumukcham Rajukumar , Singh Khoiyangbam Raju
Published: December 2022

Measurements were carried out to determine the PM2.5, PM10 and, CO2 levels in schools located in the urban areas of Imphal, Manipur. The particulate matters (PM2.5 and PM10) were monitored gravimetrically with standardised particulate samplers, while the CO2 in the air was measured by gas chromatography. Average PM2.5 and PM10 concentration in the classrooms was 41.0 ± 9.0 µg/m3 and 79.4 ± 20.2 µg/m3, respectively, and it was comparatively higher than the outdoor concentration of 34.8 ± 8.0 µg/m3 and 64.7 ± 18.9 µg/m3, respectively. The average concentration of CO2 in the indoor and outdoor air was 1250.6 ± 131.3 ∙ 103 µg/m3 and 885.7 ± 94.7 ∙103 µg/m3. The highest levels of PM2.5 (58.3 µg/m3), PM10 (112.5 µg/m3) and CO2 (1457.5 ∙ 103 µg/m3) were recorded indoors, in a school located at the heart of the city, whereas the lowest levels of PM2.5 (25.0 µg/m3), PM10 (45.8 µg/m3) and CO2 (1045.7 ∙ 103 µg/m3) were recorded in a school located away from the city centre. The levels of PM2.5 and PM10 in the air were found to exceed the permissible limits prescribed by the National Ambient Air Quality Standards in more than half of the sampling. There was a strong positive correlation between indoor and outdoor pollutant concentrations.
Complex dynamics near extinction in a predator-prey model with ratio dependence and Holling type III functional response
Authors: Blyuss Konstantin B. , Kyrychko Yuliya N. , Blyuss Oleg B.
Published: December 2022

In this paper, we analyze a recently proposed predator-prey model with ratio dependence and Holling type III functional response, with particular emphasis on the dynamics close to extinction. By using Briot-Bouquet transformation we transform the model into a system, where the extinction steady state is represented by up to three distinct steady states, whose existence is determined by the values of appropriate Lambert W functions. We investigate how stability of extinction and coexistence steady states is affected by the rate of predation, predator fecundity, and the parameter characterizing the strength of functional response. The results suggest that the extinction steady state can be stable for sufficiently high predation rate and for sufficiently small predator fecundity. Moreover, in certain parameter regimes, a stable extinction steady state can coexist with a stable prey-only equilibrium or with a stable coexistence equilibrium, and it is rather the initial conditions that determine whether prey and predator populations will be maintained at some steady level, or both of them will become extinct. Another possibility is for coexistence steady state to be unstable, in which case sustained periodic oscillations around it are observed. Numerical simulations are performed to illustrate the behavior for all dynamical regimes, and in each case a corresponding phase plane of the transformed system is presented to show a correspondence with stable and unstable extinction steady state.
Localization and potential role of prostate microbiota
Authors: Okada Koichi , Takezawa Kentaro , Tsujimura Go , Imanaka Takahiro , Kuribayashi Sohei , Ueda Norichika , Hatano Koji , Fukuhara Shinichiro , Kiuchi Hiroshi , Fujita Kazutoshi , Motooka Daisuke , Nakamura Shota , Koyama Yoshihisa , Shimada Shoichi , Nonomura Norio
Published: December 2022

Introduction

We aimed to clarify the presence and localization of the prostate microbiota and examine its association with benign prostate enlargement (BPE).

Methods

The microbiota of prostate tissues and catheterized urine from 15 patients were analyzed by 16S metagenomic analysis and compared to show that the prostate microbiota was not a contaminant of the urinary microbiota. Fluorescence in situ hybridization (FISH) and in situ hybridization (ISH) using the specific probe for eubacteria was performed on prostate tissue to show the localization of bacteria in the prostate. The BPE group was defined as prostate volume ≥30 mL, and the non-BPE group as prostate volume <30 mL. The microbiota of the two groups were compared to clarify the association between prostate microbiota and BPE.

Results

Faith’s phylogenetic diversity index of prostate tissue was significantly higher than that of urine (42.3±3.8 vs 25.5±5.6, P=0.01). Principal coordinate analysis showed a significant difference between the microbiota of prostate tissue and catheterized urine (P<0.01). FISH and ISH showed the presence of bacteria in the prostatic duct. Comparison of prostate microbiota between the BPE and non-BPE groups showed that the Chao1 index of the BPE group was significantly lower than that of the latter [142 (50–316) vs 169 (97–665), P=0.047] and the abundance of Burkholderia was significantly higher in the BPE group than in the latter.

Conclusions

We demonstrated that the prostate microbiota was located in the prostatic duct and reduced diversity of prostate microbiota was associated with BPE, suggesting that prostate microbiota plays a role in BPE.
Atrial tachycardia occurring after a prior atrial fibrillation ablation procedure: Does non-inducibility matter?
Authors: O’Neill Louisa , De Becker Benjamin , De Smet Maarten , Le Polain De Waroux Jean-Benoit , Tavernier Rene , Duytschaever Mattias , Knecht Sebastien
Published: December 2022

Recurrent atrial tachycardia (AT) is a common phenomenon after catheter ablation for AF, particularly in the setting of additional substrate ablation, with many studies demonstrating gap-related macro re-entrant AT (predominantly mitral and roof dependent) to be the dominant mechanism. Although multiple inducible ATs after ablation of the clinical AT are commonly described at repeat procedures, the optimal ablation strategy, and procedural endpoints are unclear in this setting. A recent randomized study addressing the question of non-inducibility as a procedural endpoint demonstrated no additional benefits to the ablation of all induced, non-clinical ATs, but it was limited by small numbers and high rates of non-inducibility. Nevertheless, once ablation of the clinical AT has been successfully performed, ensuring durable linear block and PV isolation may be sufficient for the prevention of further AT. Durable linear block, particularly at the mitral isthmus, is difficult to achieve but may be facilitated by the real-time evaluation of lesion quality and contiguity and the novel technique of vein of Marshall ethanol infusion. Large-scale, randomized trials are needed, nonetheless, to fully assess the optimal ablation strategy in the setting of recurrent AT post-AF ablation.
Adaptability, social support, and psychological wellbeing among university students: A 1-year follow-up study
Authors: Holliman Andrew J. , Waldeck Daniel , Holliman David M.
Published: December 2022

The transition to university is a time of great change. A recent literature has shown that adaptability (a personal resource) and social support (a conditional, situational resource) are associated with psychological wellbeing and distress among university students. However, the precise nature of these relations are unclear and there is a paucity of work investigating whether adaptability and social support are predictive of psychological wellbeing and distress over longer periods of time. In the present study, first-year university students (N = 411), were surveyed for their adaptability, social support, and psychological distress, and were then re-assessed for their psychological wellbeing and distress 1 year later. A series of moderated regression analyses, revealed that adaptability and social support were independent predictors of psychological distress concurrently, and psychological wellbeing 1 year later. Adaptability, but not social support, was also found to predict psychological distress 1 year later. No interaction effects were observed. The findings demonstrate the importance of adaptability (and social support to a lesser extent) in predicting psychological wellbeing and distress among university students both at course commencement, but also over the course of their studies 1 year later.
Testing an intervention of different learning activities to support students’ critical appraisal of scientific literature
Authors: Engelmann Katharina , Hetmanek Andreas , Neuhaus Birgit J. , Fischer Frank
Published: December 2022

In recent years, the call for an evidence-based practice has become more prevalent for educational professionals. However, educational professionals are rarely prepared for evidence-based practice; for example, teachers are not prepared to use and, thus, rarely do use scientific evidence in planning lessons. The knowledge and skills in appraising scientific literature, the basis of evidence-based practice, needs to be trained as early in professional education as possible. An effective training might start in university education of future educational professionals, engaging them in learning activities that foster their understanding of criteria that are used in appraising scientific literature and the skill to do so. However, we know little about the effect of different learning activities such as constructive or interactive learning in this context. Thus, this study investigated the influence of constructive versus interactive learning activities in the context of an intervention facilitating knowledge and skills in appraising scientific literature. This experimental study used a pre-posttest between-subject design with 105 participants. The students learned to evaluate scientific literature in an online learning environment. The results show that the inclusion of interactive versus constructive learning activities did not explain students’ learning in the intervention. The results implicate that the learning activities might not play a major role with learning contents such as evidence-based practice. However, the gain in skills and knowledge from pre- to posttest shows promising achievements in preparing future educational professionals in their evidence-based practice.
The associations between thyroid-related hormones and the risk of thyroid cancer: An overall and dose-response meta-analysis
Authors: Wang Zheng , Lin Yuxin , Jiang Yixian , Fu Rong , Wang Yabing , Zhang Qian
Published: December 2022

Objective

Thyroid cancer (TC) is one of the most common malignant tumours of the endocrine system. Thyroid-stimulating hormone (TSH) is known as being a risk factor for TC, but other thyroid-related hormones are inconsistently associated with TC. The purpose of this study was to comprehensively evaluate the relationships between thyroid-related hormones and the risk of TC.

Methods

This study utilized searches of PubMed, Embase, Web of Science and Cochrane library up to the date of March 31st, 2022. Additionally, we performed a systematic review of related original studies combining overall and dose–response meta-analyses.

Results

A total of 30, 5 and 7 articles were included in the meta-analyses of TSH, Free triiodothyronine (FT3), free thyroxine (FT4) and TC risk with 58437, 6813 and 7118 participants respectively. An increased risk of TC was associated with high TSH exposure (OR=1.28, 95% CI: 1.19-1.37, P < 0.001) in the overall meta-analysis. For every 1 mU/L increase in TSH, the risk of TC increased by 16%. However, in those studies that used healthy subjects as controls, the association was not statistically significant(P=0.62). Additionally, high serum FT3 demonstrated a reduced risk of TC, with a combined OR of 0.86 in the fixed-effect model (95% CI: 0.81–0.90, P < 0.001). In addition, a statistically significant increase in TC risk was found when FT4 concentrations reached a certain threshold (approximately 2.2 ng/dL) in the dose-response meta-analysis.

Conclusions

Significant associations between thyroid-related hormones and the risk of TC were found in this study. Further research is needed to understand the underlying mechanisms.
Clinical relevance of genetic polymorphisms in WNT signaling pathway (SFRP1, WNT3A, CTNNB1, WIF-1, DKK-1, LRP5, LRP6) on pulmonary tuberculosis in a Chinese population
Authors: Huang Qian , Wang Chao-Cai , Liu Yun-Guang , Zhao Chang-Ming , Zhang Tian-Ping , Liu Yan , Wang Hua
Published: December 2022

The present study was performed to evaluate the association of WNT signaling pathway genes variants with pulmonary tuberculosis (PTB) risk in Chinese Han population. Our study subjects were composed of 452 PTB patients and 465 normal controls, and seventeen SNPs of seven genes in WNT signaling pathway (SFRP1, WNT3A, CTNNB1, WIF-1, DKK-1, LRP5, LRP6) were genotyped by SNPscan technique. We found no significant relationship of SFRP1 rs10088390, rs4736958, rs3242, WNT3A rs752107, rs3121310, CTNNB1 rs2293303, rs1798802, rs4135385, WIF-1 rs1026024, rs3782499, DKK-1 rs2241529, rs1569198, LRP5 rs3736228, rs556442, LRP6 rs2302685, rs11054697, rs10743980 polymorphisms with PTB susceptibility. While, WIF-1 rs3782499 variant was associated with susceptibility to PTB under recessive model, and haplotype analysis showed that DKK-1 GA haplotype frequency was significantly increased in PTB patients. The WNT3A rs3121310, CTNNB1 rs2293303 polymorphisms were respectively associated with drug-induced liver injury (DILI), sputum smear-positive in PTB patients. The rs3782499 in WIF-1 gene was related to fever, leukopenia, and the rs1569198 in DKK-1 was linked to sputum smear-positive in PTB patients. In LRP5 gene, rs3736228, rs556442 variants respectively affected the occurrence of DILI, fever, and LRP6 gene rs2302685, rs10743980 variants respectively influenced the development of hypoproteinemia, sputum smear-positive in PTB patients. Our results revealed that WNT signaling pathway genes variation were not associated with the susceptibility to PTB, while WNT3A, CTNNB1, WIF-1, DKK-1, LRP5, LRP6 genetic variations might be closely related to the occurrence of several clinical characteristics of PTB patients.
B21 DNA vaccine expressing ag85b, rv2029c, and rv1738 confers a robust therapeutic effect against latent Mycobacterium tuberculosis infection
Authors: Weng Shufeng , Zhang Jinyi , Ma Huixia , Zhou Jingyu , Jia Liqiu , Wan Yanmin , Cui Peng , Ruan Qiaoling , Shao Lingyun , Wu Jing , Wang Honghai , Zhang Wenhong , Xu Ying
Published: December 2022

Latent tuberculosis infection (LTBI) treatment is known to accelerate the decline in TB incidence, especially in high-risk populations. Mycobacterium tuberculosis (M. tb) expression profiles differ at different growth periods, and vaccines protective and therapeutic effects may increase when they include antigenic compositions from different periods. To develop a post-exposure vaccine that targets LTBI, we constructed four therapeutic DNA vaccines (A39, B37, B31, and B21) using different combinations of antigens from the proliferation phase (Ag85A, Ag85B), PE/PPE family (Rv3425), and latent phase (Rv2029c, Rv1813c, Rv1738). We compared the immunogenicity of the four DNA vaccines in C57BL/6j mice. The B21 vaccine stimulated the strongest cellular immune responses, namely Th1/Th17 and CD8+ cytotoxic T lymphocyte responses. It also induced the generation of strengthened effector memory and central memory T cells. In latently infected mice, the B21 vaccine significantly reduced bacterial loads in the spleens and lungs and decreased lung pathology. In conclusion, the B21 DNA vaccine can enhance T cell responses and control the reactivation of LTBI.
Mechanical high-intensity focused ultrasound creates unique tumor debris enhancing dendritic cell-induced T cell activation
Authors: van den Bijgaart Renske J. E. , Mekers Vera E. , Schuurmans Fabian , Raaijmakers Tonke K. , Wassink Melissa , Veltien Andor , Dumont Erik , Heerschap Arend , Fütterer Jurgen J. , Adema Gosse J.
Published: December 2022

Introduction

In situ tumor ablation releases a unique repertoire of antigens from a heterogeneous population of tumor cells. High-intensity focused ultrasound (HIFU) is a completely noninvasive ablation therapy that can be used to ablate tumors either by heating (thermal (T)-HIFU) or by mechanical disruption (mechanical (M)-HIFU). How different HIFU ablation techniques compare with respect to their antigen release profile, their activation of responder T cells, and their ability to synergize with immune stimuli remains to be elucidated.

Methods and results

Here, we compare the immunomodulatory effects of T-HIFU and M-HIFU ablation with or without the TLR9 agonist CpG in the ovalbumin-expressing lymphoma model EG7. M-HIFU ablation alone, but much less so T-HIFU, significantly increased dendritic cell (DC) activation in draining lymph nodes (LNs). Administration of CpG following T- or M-HIFU ablation increased DC activation in draining LNs to a similar extend. Interestingly, ex vivo co-cultures of draining LN suspensions from HIFU plus CpG treated mice with CD8+ OT-I T cells demonstrate that LN cells from M-HIFU treated mice most potently induced OT-I proliferation. To delineate the mechanism for the enhanced anti-tumor immune response induced by M-HIFU, we characterized the RNA, DNA and protein content of tumor debris generated by both HIFU methods. M-HIFU induced a uniquely altered RNA, DNA and protein profile, all showing clear signs of fragmentation, whereas T-HIFU did not. Moreover, western blot analysis showed decreased levels of the immunosuppressive cytokines IL-10 and TGF-β in M-HIFU generated tumor debris compared to untreated tumor tissue or T-HIFU.

Conclusion

Collectively, these results imply that M-HIFU induces a unique context of the ablated tumor material, enhancing DC-mediated T cell responses when combined with CpG.