bluuebunny/crossref_metadata_2025 huggingface dataset:
Prognostic assessment of processes of formation of high professional suitability of students purchasing the specialties of rehabilitation profile
Authors:   National Pirogov Memorial Medical University, Vinnytsia, Ukraine, Serheta I.V. , Marchuk O.V. ,   National Pirogov Memorial Medical University, Vinnytsia, Ukraine
Published: December 2024

The aim of the study was to justify the methodology of comprehensive prognostic assessment of the processes of formation of high professional suitability of students who acquire specialties of rehabilitation specialists, taking into account the degree of development of professionally important psychophysiological functions and personality traits.

Research materials and methods. The research was conducted on the basis of National Pirogov Memorial Medical University, Vinnitsya. A complex of hygienic, psychophysiological and psychodiagnostic methods, methods of statistical analysis and expert evaluations was used to realize the set goal.

The results. In the course of research, it was determined that the main stages of the practical interpretation of the methodology of complex prognostic assessment of the processes of formation of high professional suitability of students who acquire specialties of the rehabilitation profile are: determination on the basis of the application of modern instrumental and test (computerized) methods of the degree of expression of the leading professionally important psychophysiological personality functions and personality traits (diagnostic stage); evaluation of the obtained data in standardized points in accordance with specially created point-based assessment scales of the level of development of psychophysiological functions and personality traits according to psychophysiological and personal loci (standardization stage); calculation, according to generalized formulas, of the success rates of the processes of forming the professional fitness of students who acquire the specialties of a doctor of physical and rehabilitation medicine, a physical therapist and occupational therapist, assistant of a physical therapist and assistant of an occupational therapist (calculation stage). evaluation of the peculiarities of the process of formation of professional suitability of students, based on the application of quantitative criteria of meaningful assessment (interpretation stage); determination of individualized strategies for the use of means of psychophysiological influence and psychohygienic correction of deviations that occur (correction stage).

Conclusions. In the course of the research, a scientifically based complex prognostic assessment method was developed based on the degree of development of psychophysiological functions and personality characteristics, which provides an opportunity to determine the peculiarities of the course of the processes of psychophysiological and mental adaptation of students who acquire specialties of rehabilitation specialists.
Implementing and Analyzing Web Performance Testing for Universitas Terbuka’s Website with GTMetrix and Pingdom
Authors: Putri Mayang Anglingsari
Published: December 2024

A higher education institution's website allows lecturers and students to search for necessary information online. Good web performance is essential to provide better service to users. This research focuses on analyzing and testing the performance of a university website to maximize its efficiency. Performance testing measures a website's effectiveness. In this study, we analyze the website of Universitas Terbuka (UT), known for its distance learning system. The goal is to assess the website’s performance using testing tools like GTMetrix and Pingdom, which automatically analyze web performance. These tools provide data on the website's performance, which is then processed into information about strengths, weaknesses, and potential solutions. The outcome includes a comparison of performance metrics from GTMetrix and Pingdom. This research contributes to evaluating UT’s website performance and offers insights to help developers enhance and optimize the application to the desired level.
Redistribusi Tanah Dalam Meningkatkan Kesejahteraan Petani
Authors: Quraisy Raflinov , Primasatya Sigit , Ajeng Muninggar Roro , Istianti Ria , Purwanto Hari , Restya Safira Excha , Fikriadin Rahmansyah
Published: December 2024

Redistribusi tanah merupakan salah satu program utama dalam reforma agraria yang bertujuan untuk mengurangi ketimpangan kepemilikan tanah dan meningkatkan kesejahteraan petani. Pelaksanaan redistribusi tanah saat ini belum berjalan secara maksimal. Atas hal tersebut perlu dilakukan kajian mengenai perkembangan program reforma agraria melalui redistribusi tanah dapat mengatasi permasalahan ketimpangan kepemilikan tanah untuk meningkatkan kesejahteraan petani serta langkah-langkah apa yang perlu diambil oleh Presiden dan Wakil Presiden terpilih untuk mendukung dan meneruskan pencapaian pelaksanaan redistribusi tanah. Metode penelitian normatif serta studi kepustakaan digunakan dalam penulisan artikel ini. Hasil penelitian menunjukkan bahwa redistribusi tanah telah memberikan dampak positif dalam mengurangi ketimpangan kepemilikan tanah dan meningkatkan kesejahteraan petani, terutama dalam peningkatan akses terhadap sumber daya agraria dan peningkatan produktivitas pertanian. Namun, terdapat berbagai tantangan yang perlu diatasi, seperti birokrasi yang kompleks, konflik lahan, dan kurangnya dukungan infrastruktur. Untuk mendukung dan meneruskan pencapaian pelaksanaan redistribusi tanah, Presiden dan Wakil Presiden terpilih perlu mengambil beberapa langkah strategis antara lain memperkuat kerangka hukum dan kebijakan terkait reforma agraria, meningkatkan koordinasi antar lembaga pemerintah, menyediakan dukungan infrastruktur teknologi bagi petani, serta tersedianya pendampingan atas tindak lanjut dari redistribusi tanah. Langkah-langkah tersebut diharapkan dapat mendukung pelaksanaan redistribusi tanah
IDEALISME HUKUM SEBAGAI CONTROL SOSIAL DALAM HARAPAN MENEKAN SEKS BEBAS DIKALANGAN REMAJA
Authors: Iqbal Muhamad , Indriani Iin
Published: December 2024

ABSTRACT: Teenagers, especially female teens, also struggle with understanding adolescent reproductive health, according to the 2018 Indonesian Demographic and Health Survey (SDKI). K.R. For example, only 33% of female teenagers have a firm grasp of the reproductive period, 81% have dated, and roughly 44% have dated between the ages of 15 and 17. In addition, 15% of abortion cases in 2018 were related to unplanned pregnancies, and 30% of teenage girls have engaged in premarital Seks. In order to reduce premarital Seks among adolescents, it is necessary to address the following questions: How does the form of legal intervention as social control fit into the context of adolescent life? How does the idea of legal social control work? This study was qualitative, non-interactive, and used document analysis to provide interpretations of ideas, policies, and events both directly and indirectly. Whether they are inclined to engage in deviant behavior or not is determined by four basic types of connections that society has made. The four types of bonds that were previously covered are belief, participation, commitment, and attachment. Commitment recognizes "the importance of social relationships that people value, which they do not want to risk jeopardizing by engaging in criminal or deviant acts."The emotional bond that teenagers have with their family is comparable to this type of bond. Children may behave badly if their home environment is perfect, such as when parents divorce or there are family disputes. Adolescent Life: Legal Intervention as Social Control Using Micro and Macro Strategies in the Context of Adolescent Life The concept of basic bonds and the factors that influence them can be used to define the role that the law plays in social control in this regard. This is one of two possible combinations of the idea that the law serves as social control in the hope of reducing premarital Seks among adolescents.
Easy and eco-friendly way for silver nanoparticles synthesis using Lotus corniculatus L: characterization and antibacterial activity
Authors: Assia Bessi , Hamza Kahina , Boudine Boubkeur , Boudaren Chaouki
Published: December 2024

Lotus corniculatus L. is a plant that has recently proven a significant effect in anticancer therapies. On the other side, silver nanoparticles have always proven to demonstrate pronounced antimicrobial and anti-inflammatory properties. To harness the collective advantages of both entities, we synthesized silver nanoparticles using an aqueous extract of Lotus corniculatus L. In this synthesis, we used a solution of AgNO3 as a precursor of Ag, while existing bioactive molecules in the extract acted as a reducing agent and natural stabilizer of formed nanoparticles.

Structural characterization of the product was done by X-ray diffractometry (XRD) and infrared spectroscopy (FT-IR). Scanning electron microscopy with energy dispersive X-rays (SEM with EDX) was used to investigate nanoparticles morphology, and optical characterization was completed by Ultraviolet-visible spectrophotometry (UV-Vis).
An absorption edge at 420 nm and a noticeable color shift in the extract following the addition of the precursor demonstrated the AgNPs formation. SEM verified that the nanoparticles were spherical and had an average size of 17 nm. Importantly, the synthesized nanoparticles displayed an important antimicrobial activity, which is exhibited more remappable counter to gram-negative (Escherichia coli, Pseudomonas aeruginosa) than gram-positive (Bacillus subtilis). These findings underscore the potential of the Lotus corniculatus L. extract in silver nanoparticles synthesis as a promising avenue for applications in medicine and antimicrobial therapies.
Pengaruh Modifikasi Permainan Sirkuit terhadap Hasil Belajar Passing Bolabasket
Authors: Ahmad Nurdian , Saputra Yudi Dwi
Published: December 2024

Modifikasi merupakan upaya penyampaian suatu materi dengan memberikan kaidah-kaidah yang disesuaikan dengan kebutuhan dan tujuan yang ingin dicapai dalam kegiatan pembelajaran. Tujuan penelitian ini adalah untuk mengetahui pengaruh modifikasi permainan sirkuit terhadap hasil belajar passing basket pada siswa di SMPN 3 Peterongan Kabupaten Jombang. Penelitian ini merupakan penelitian eksperimen dengan desain dalam penelitian ini one group pre-test post test design. Sampel dalam penelitian ini adalah siswa kelas VIII SMPN 3 Peterongan, pengambilan sampel dalam penelitian menggunakan cluster random sampling dengan jumlah siswa 30 orang. Pada penelitian ini, hasil uji t Sampel Berpasangan untuk modifikasi permainan rangkaian menunjukkan bahwa nilai sig 0,00 kurang dari (0,05) sehingga dapat ditafsirkan bahwa H0 ditolak, Ha diterima sedangkan untuk hasil t hitung menunjukkan bahwa t hitung lebih besar dari tabel t yaitu 10,247>2,045. Dengan demikian, dari kedua hasil perhitungan tersebut dapat diartikan bahwa terdapat perbedaan pengaruh yang signifikan antara pre-test dan post-test. Dengan kata lain, terdapat pengaruh modifikasi permainan sirkuit terhadap hasil belajar passing basket pada siswa di SMPN 3 Peterongan.
Göz İçi Lens Materyallerin Oftalmoloji Alanında Yolculuğu ve Modern Cerrahideki Yeri
Authors: Erdağ Murat , Çıtırık Mehmet
Published: December 2024

Katarakt, önlenebilir önemli bir sağlık sorunudur. Katarakt cerrahisinde kullanılan göz içi lensler (GİL'ler), cerrahi sonrası görme kalitesini artırmak için önemli bir role sahiptir. Katarakt cerrahisi sırasında göz içine konulan lensler (GİL) çeşitli materyallerden yapılmaktadır. Başlangıçta polimetilmetakrilat (PMMA) malzemesinden yapılan GİL'ler, zamanla silikon ve akrilik gibi daha gelişmiş materyallerle yer değiştirmiştir. GİL'ler, biyouyumluluk, optik performans ve hasta konforu açısından sürekli olarak geliştirilmektedir. Ayrıca, multifokal, akomodatif ve ayarlanabilir lensler gibi yeni teknolojilerle, farklı mesafelerde net görme sağlanması hedeflenmektedir. Bu makalede, GİL'lerin gelişimi, mevcut durumu, kullanılan materyallerin özellikleri ve bu lenslerin sınıflandırılması üzerinde durulmuştur.
Usnik Asit SH-SY5Y Nöroblastom Hücrelerinde Tümör Baskılayıcı Genleri Aktive Ederek Apoptozu Tetikler ve İnvazyonu Azaltır
Authors: Oy Ceren , Serter Koçoğlu Sema
Published: December 2024

Usnik asit, Usnea diffracta Vain'den kaynaklanan bir dibenzofuran bileşiğidir ve anti-inflamatuar, antifungal ve antikanser etkileri vardır. Ancak, antitümör etkilerinin moleküler mekanizması tam olarak açıklanmamıştır. Bu çalışma, usnik asidin nöroblastom hücrelerinde antikanser aktivitesinin altında yatan apoptoz ve otofaji aracılı mekanizmaları belirlemeyi amaçlamaktadır. Usnik asidin SH-SY5Y nöroblastom hücre canlılığı üzerine etkileri CCK-8 testi, hücre migrasyonu üzerine etkileri yara iyileşme deneyi, invazyon, apoptoz, otofaji ve tümör baskılayıcı genler üzerine etkileri ise Western blot ile değerlendirilmiştir. Usnik asidin SH-SY5Y nöroblastom hücre canlılığını doz ve zaman bağımlı olarak azalttığı gösterilmiş ve IC50 dozu 24 saatte 10 μM olarak belirlenmiştir. Usnik asidin nöroblastom hücre migrasyonu ve invazyonunu anlamlı olarak azalttığı gösterilmiştir. Kontrol grubu yara alanı 0. saatte ortalama 628,9 ± 35,59 cm2 iken 24 saatte 234,8 ± 30,98 cm2 olarak belirlenmiştir. Usnik asit yara alanı ise 0. saatte ortalama 895,2 ± 30,07 cm2 iken 24 saatte 801,9 ± 15,23 cm2’dir. Usnik asidin nöroblastom hücre apoptozunu indüklediği belirlenmiştir. Usnik asit kesilmiş kaspaz-3 ekspresyonunda 4 katlık bir artışa neden olmuş, otofaji markırlarında ise bir değişiklik oluşturmamıştır. Usnik asit uygulaması SH-SY5Y nöroblastom hücrelerinde tümör baskılayıcı genlerin ekspresyonunda artışa neden olmuştur. Sonuç olarak, usnik asidin nöroblastom hücrelerinde tümör baskılayıcı genleri aktive ederek apoptozu tetikleyebileceği, böylelikle invazyon, migrasyon ve hücre canlılığında azalışa neden olabileceği gösterilmiştir. Usnik asidin nöroblastom hücrelerinde antikanser aktivitesinin altında yatan mekanizmaların daha ileri çalışmalarla desteklenmesi gerekmektedir.
Optimiranje prometa u gradu Opatiji primjenom modela prometne mikrosimulacije
Authors: Fatić Edin , Deluka-Tibljaš Aleksandra , Ištoka Otković Irena , Klobučar Mirna , Šurdonja Sanja
Published: December 2024

In this paper traffic and construction solution for converting the main city street in Opatija, Maršala Tita Street, from a two-way street to a one-way street with additional longitudinal parking and diverting traffic to the parallel corridor, state road D66 (Ulica Nova cesta), is presented. The solution was analyzed using the traffic model created in the VISSIM software package. It turned out that such a solution would have a negative impact on the traffic flow on the state road D66.
САМОПРЕЗЕНТАЦІЯ ЯК НЕВІД’ЄМНИЙ ЕЛЕМЕНТ ПРОФЕСІЙНОЇ ПІДГОТОВКИ ФАХІВЦЯ МУЗИЧНОГО МИСТЕЦТВА
Authors: СУХОЛОВА Маріанна
Published: December 2024

У статті здійснено теоретичний аналіз та порівняння підходів до визначення феноменів «презентація», «самопрезентація». На основі вивчення сучасних теорій розглянуто особливості явища самопрезентації майбутніх фахівців музичного мистецтва. Термін «самопрезентація» використано як синонім управління враженнями для позначення численних стратегій і технік, які використовує особистість під час створення та контролю свого внутрішнього іміджу і вражень про себе, які вона демонструє оточенню. Аналіз наукових доробок дозволяє стверджувати, що науковці, розкриваючи сутність визначених категорій, окреслюють їх як нову філософську парадигму. На основі теоретичного узагальнення подається власна інтерпретація феномену «самопрезентація» – це ефектне представлення особистісно-професійних якостей, досвіду, досягнень, спрямоване на формування позитивного враження, інтересів, особистісних ідеалів, цінностей, переконань й інших компонентів професійної діяльності фахівця музичного мистецтва.
KORUMA SORUMLULUĞU, ULUSLARARASI TEAMÜL HUKUKU HALİNE GELMİŞ MİDİR? SORUNSALIN HİPOTETİK BİR BAKIŞLA ANLATISI
Authors: Yavuz Sevgi Tansu , Mutlu Erdem İlker
Published: December 2024

Çalışmada uluslararası teamül hukukunun kurucu unsurlarından olan maddi unsur ile manevi unsur (opinio juris) üzerinden değerlendirme yapılarak koruma sorumluluğunun bir uluslararası teamül hukuku kuralı halini alıp almadığı değerlendirmesi yapılmaya çalışılmıştır. Birleşmiş Milletler (BM) organları her ne kadar koruma sorumluluğunu doğrulamış olsa da ortak bir devlet uygulaması olan maddi unsurun eksikliği ile opinio juris şartını gerçekleştirme unsuru açısından birçok karşı görüşün varlığıyla uluslararası teamül hukuku kuralı halini alamamıştır. Devletlerin koruma sorumluluğuna atfedilen hukuki niteliklere rağmen koruma sorumluluğu doktrinini devletlerin menfaatlerine göre şekillendirebilmekte olduğu göz önüne alındığında, koruma sorumluluğunu teamül hukuku olarak nitelemenin epey zorlama olacağı ortaya çıkmaktadır.
Koruma sorumluluğu doktrini çoğu zaman devletlerin menfaatlerine göre yorumlanabilmekte olduğundan doktrinin dayandığı normlar teamül hukuku halini alamamıştır. Hatta birçok zaman bu doktrin dayanak olarak dahi kullanmaya cesaret edilememektedir. Çalışmada bu hususa güncel bir örnek olarak; Güney Afrika Cumhuriyeti’nin Uluslararası Adalet Divanı’na (UAD ya da Divan) Filistin meselesini taşıdığı davayı gösterebiliriz.
İsrail’in 1948 tarihli BM Soykırımın Önlenmesi ve Cezalandırılması Sözleşmesi’ni ihlal ederek Filistin’de gerçekleştirdiği insanlığa kaşı suçun, Güney Afrika Cumhuriyeti tarafından Uluslararası Adalet Divanı’na (UAD ya da Divan) taşınması ve akabindeki gelişmelerde hiçbir devletin koruma sorumluluğu doktrinini dayanak yapmamış olması bunun en büyük örneğidir. O nedenle bu doktrinin merkezine aldığı “soykırıma maruz kalmış bir kitleyi” konu alan davada dahi son derece iyi hukukçulara sahip olan Güney Afrika Cumhuriyeti iddiasında koruma sorumluğu kavramına yer vermemiştir. Bu nedenle güncel ve çarpıcı bir örnek olarak çalışmada, Güney Afrika Cumhuriyeti’nin hangi hukuki sorunlara koruma sorumluluğu doktrininden daha fazla öncelik verdiğine değinilmiştir.
Hard Work: Producing places, relations and value on a Papua New Guinea resource frontier
Authors: Tammisto Tuomas
Published: December 2024

For the Mengen people of Papua New Guinea, ‘hard work’ does not refer to drudgery or physically exhausting labour. Instead, it involves creating and recreating social relations through acts of care, marriages, ceremonial events, sharing, and working the land together. ‘Work’ as the Mengen see it, produces value understood as meaningful social relations. This differs significantly from the way colonial officials, loggers, and planters perceived value.

Hard Work examines human-environmental relations, value production, natural resource extraction, and state formation within the context of the Mengen. It delves into how the Mengen engage with their land and outside actors like companies, NGOs, and the state through agriculture, logging, plantation labour, and environmental conservation. These practices have shaped the Mengen’s lived environment, while also sparking debates on what is considered valuable and how value is created.

Tammisto’s monograph explores the complexities of natural resource extraction, looking at both large-scale processes and personal human-environment interactions. It combines a political ecology focus on the connection between environmental issues and power relations with a focus on how value is produced, represented, and materialized.
La influencia de la inteligencia artificial en la administración de justicia: una transformación en el sistema judicial
Authors: Rodríguez Barroso Christian , Martínez Cisneros Lizbeth
Published: December 2024

INTRODUCCIÓN. El uso de la inteligencia artificial (IA) en los sistemas judiciales es una realidad cada vez más cercana, debido al impulso e incremento en la capacidad de procesamiento de datos y el perfeccionamiento de algoritmos más sofisticados. Estas tecnologías tienen el potencial de optimizar la administración de justicia y mejorar la gestión judicial. Sin embargo, la integración de IA en el sistema procesal presenta desafíos significativos, como determinar la suficiencia e idoneidad que tiene con el marco normativo vigente ecuatoriano. MÉTODO. El método empleado en la investigación se basa en un enfoque cualitativo, empleando una revisión exhaustiva de documentación relevantes, jurisprudencia y normativa nacional e internacional. OBJETIVO. Con base en lo expuesto se determina si el reconocimiento de la Inteligencia Artificial no vulnera derechos fundamentales y mejoraría la eficiencia y precisión en diversas tareas legales. DISCUSIÓN Y CONCLUSIONES. Finalmente se concluye que, el uso de IA tiene el potencial de revolucionar el sistema judicial ecuatoriano, mejorando la eficacia y eficiencia en la administración de justicia, siempre y cuando se garantice su uso ético y regulado.
La garantía de la motivación en la jurisprudencia de la Corte Constitucional del Ecuador
Authors: Borja Roldán Byron Alejandro , Borja Roldán Adrián Andrés
Published: December 2024

INTRODUCCIÓN. El presente trabajo analiza la garantía de la motivación en el ordenamiento jurídico ecuatoriano. Para este fin, en aplicación del método dogmático jurídico, se delimita su incorporación en la normativa infra constitucional y se expone criterios doctrinarios de su relación con la argumentación jurídica y su aplicación como mecanismo para legitimar y auditar decisiones judiciales. Además, se efectúa un análisis de la sentencia 1158-17-EP/21 exponiendo el desarrollo jurisprudencial que ha tenido la Corte Constitucional desde la expedición del criterio rector de la motivación. OBJETIVO. El presente trabajo tiene por objetivo analizar la garantía de la motivación en el ordenamiento jurídico ecuatoriano, destacando así su evolución en la jurisprudencia de la Corte Constitucional del Ecuador, tomando como base los criterios de la sentencia 1158-17-EP/21. MÉTODO. El método de investigación es cualitativo. DISCUSIÓN Y CONCLUSIONES. Finalmente, se presentan los parámetros de aplicación de la jurisprudencia de la Corte Constitucional del Ecuador al analizar la garantía de la motivación en los casos sometidos a su conocimiento.
EDITORIAL: LA REALIDAD HUMANA Y LA DINÁMICA DEL DERECHO
Authors: Murillo Martínez Jorge Eduardo
Published: December 2024

La Realidad Humana y la dinámica del Derecho aborda trabajos de diferentes juristas ecuatorianos. El primer artículo borda sobre la Institución del Reclamo Administrativo Tributario en el Ecuador que revisa y analiza objetivamente las disposiciones nacionales respecto de la institución jurídica en cuestión. Luego, se trata el tema de la conciliación como un mecanismo de resolución de conflictos introducida por la legislación ecuatoriana como una etapa o fase procesal en los juicios relacionados con materia de alimentos. A la vez se estudia el uso de la inteligencia artificial (IA) en los sistemas judiciales debido a que es una realidad cada vez más cercana. De la misma manera, se analiza la admisibilidad de la prueba según el COGEP y la motivación de sentencias como elemento del debido proceso en Ecuador. También se estudia las políticas públicas dirigidas al empleo juvenil desde la óptica del derecho público, identificando sus limitaciones y proponiendo mejoras. Y su impacto en la provincia de Tungurahua. Finalmente, se examina la sentencia 1158-17-EP/21, subrayando el desarrollo jurisprudencial impulsado por la Corte Constitucional sobre este criterio rector. El estudio analiza la garantía de la motivación en el sistema jurídico ecuatoriano, abordando su incorporación en la normativa infraconstitucional y su relación con la argumentación jurídica.
Pengaruh Kenaikan Tarif Ojek Online Terhadap Pendapatan Driver Ojek Online Di Stasiun Bekasi
Authors: Ar Rizqi Muhammad Farhan , Irawan Pristanto Ria , Supriyadi Supriyadi
Published: December 2024

Tujuan penelitian ini adalah untuk mengetahui bagaimana pengaruh kenaikan tarif ojek online terhadap pendapatan pengemudi di Stasiun Bekasi. Menaikkan tarif ojek online seringkali dipandang sebagai langkah yang diperhitungkan untuk meningkatkan kesejahteraan mitra berkendara. Mengingat banyak variabel lain, termasuk perubahan jumlah klien, tingkat persaingan, dan variasi permintaan, pengaruhnya terhadap total pendapatan masih menjadi perdebatan. Penelitian ini menggunakan metode survei dan metodologi kuantitatif, dengan mengumpulkan data dari 60 orang pengemudi ojek online di wilayah Stasiun Bekasi yang mengisi kuesioner.
Untuk mengetahui hubungan antara variabel independen (kenaikan tarif) dengan variabel dependen (pendapatan pengemudi), analisis data dilakukan dengan menggunakan regresi linier. Berdasarkan temuan studi tersebut, pendapatan pengemudi sangat dipengaruhi oleh kenaikan tarif. Namun dampaknya tidak sepenuhnya menguntungkan karena seiring berjalannya waktu, hal ini juga disertai dengan penurunan jumlah klien. Penelitian ini menggunakan metodologi deskriptif kuantitatif, yaitu pengumpulan data melalui kuesioner. Penelitian ini menggunakan metodologi analisis regresi linier dan purposive sampling dengan sampel sebanyak 60 orang pengemudi ojek online di wilayah stasiun kereta api bekasi, Jawa Barat.
Temuan penelitian menunjukkan bahwa di stasiun kereta api bekasi di Jawa Barat, terdapat hubungan parsial antara kenaikan tarif ojek online dengan pendapatan pengemudi ojek. Temuan penelitian ini diharapkan dapat membantu penyelidikan di masa depan.
KENDİ/KENDİSİ ADILLARININ TÜMCEİÇİ VE TÜMCELERARASI GÖNDERGESEL ÖZELLİKLERİ: TÜMDENGELİMLİ VE TÜMEVARIMLI BİR BAKIŞ
Authors: Küçüksakarya Esra , Özgen Murat
Published: December 2024

Kendi ve kendisi dönüşlülük adılları yalın ve çekimli biçimlerde iki türden oluşur. Gözlemsel açıdan kendi bir dönüşlü adıl olarak yerel bir öncülle bağlanırken; kendisi ise uzun soluklu bir gönderge olarak ana tümcenin öznesine bağlanabilir. Bununla birlikte, kendi adılı hem tümceiçi hem tümcedışı bir öncülle bağlanabilir. Üretici Dilbilgisi (ÜD) kapsamında biçimsözdizimsel ve anlambilimsel açıdan incelenen öncül-gönderge ilişkisi; Metinsellik Ölçütlerinin (MÖ) Bağlaşıklık İlkesi çerçevesinde ise söylem-edim ve metindilbilim alanına konu olmaktadır. MÖ kapsamında başkaca bir birimin yerini tutan metiniçi dilsel ögeler olarak dönüşlülük adılları, tümcelerarası dilbilgisel bağlaşıklık kurmaktadır. Sözü geçen iki bakış açısından ÜD tümdengelimli, MÖ tümevarımlı bir bakış açısıdır. Bu görüşler doğrultusunda, araştırmanın amacı TS Corpus V2 veritabanından 1000 sözceyi tarayarak kendi ve kendisi adıllarının tümceiçi ve tümcelerarası sunuluşlarını, sözdizim ve metinsellik koşullarına göre bağlama olgusu açısından değerlendirip kuramsal ve uygulamalı bir biçimde incelemektir. Buna göre, tümce içindeki gönderimlerin çekimli, çekimsiz biçimlenmeleri ve tümcelerarası göndergesel özellikleri dikkate alındığında, kendi ve kendisi adıllarının yedi alt ulamda yapılandığı gözlemlenmiştir. Kendi adılının tümceiçi artgönderim kurulumunun, kendisi adılının ise tümcelerarası artgönderim kurulumunun daha sık gerçekleştiği ve artgönderimin öngönderimden daha sık kullanıldığı saptanmıştır. Ayrıca, tümdengelimle türetilen anlam bulanıklığına sahip tümcelerin, tümevarımla incelenen derlemde bulunmadığı ve ulamlar arasında istatistiksel olarak anlamlı bir fark olmasa da iki adıl arasında pozitif yönlü bir ilişki olduğu gözlemlenmiştir. Alanyazında kuramsal ve uygulamalı olarak biçimci ve işlevci bakış açılarıyla (tümdengelim ve tümevarım) ele alınan kendi ve kendisi adıllarının her iki düzlem ekseninde değerlendirilmesi bu çalışmayı önceki araştırmalardan ayırır. Ayrıca, biçimsel özelliklerin saptanması için anadil konuşucusunun sezgi ve yargılarının benimsenmesinin yanı sıra veritabanında yer alan yazılı metinlerle karşılaştırarak incelemek biçim-işlev ekseninde yürütülecek başkaca çalışmalara katkı sağlayacaktır.
THE EFFECTS OF ENGLISH LANGUAGE TEACHING ENRICHED WITH DIGITAL APPLICATIONS ON TEACHER COGNITION AND STUDENT BELIEFS
Authors: Arıkan Aslıhan , Peçenek Dilek
Published: December 2024

The purpose of this study was to determine whether English language teaching enriched with digital applications had an impact on teacher cognition and student belief. 49 English teachers working at the K12 level at a private school's campuses in 35 different cities and 214 students of these teachers participated in this research. With this diversity, it was aimed to increase the representative power of the sample. In order to determine teachers’ cognition and student beliefs towards English Language Teaching, an online questionnaire on English Language Teaching enriched with digital applications was administered to both teachers and students. Following the in-service training on English language education enriched with digital applications, teachers implemented the in-class practices with their students, and the questionnaire was administered again. It was investigated whether this process created a change in teachers’ cognition and student beliefs or not. When the pre- and post-surveys were compared, the results showed that in-service training had a positive impact on teachers' cognitions and students' beliefs. Besides, the parallel rise in teacher and student results emphasized the cyclical effect of teacher cognition on classroom practices and student beliefs. This study contributes to English Language Teaching (ELT) field by investigating the effects of English Language Teaching enriched with digital applications at the K-12 level on teacher cognition and student beliefs, as well as providing the opportunity to observe the lessons using the trilogy method fed from three different perspectives: teacher, student, and observer.
DERLEM DİLBİLİM İLE GENÇLİK DİLİNE BAKIŞ: TÜRKÇE İÇİN İHTİYAÇLAR VE GELİŞİM ALANLARI
Authors: Efeoğlu Özcan Esranur , Işık Güler Hale
Published: December 2024

Gençlerin dil pratikleri; hem akademi hem de toplum tarafından sıklıkla mercek altına alınan bir olgu olmasına rağmen, Türkçe konuşan gençler tarafından kullanılan çağdaş sözlü Türkçenin sistematik ve tutarlı araştırma yöntemleri ile incelendiği dilbilimsel araştırmalar yok denecek kadar azdır. Bu makale, öncelikle gençlik diline odaklanan güncel dilbilim tartışma ve paradigmaları araştırmacıların dikkatine sunmakta, ardından da Türkçe alan yazında gençlik diline dair mevcut araştırmaları eleştirel bir bakış ile irdelemektedir. Son olarak da Türkçe gençlik dili araştırmalarında sürdürülebilir, hesap verebilir, birikimli çalışmalara katkıda bulunmak için öncül bir çalışma olarak oluşturulan Türkçe Gençlik Dili Derlemi (CoTY) (Corpus of Turkish Youth Language) tanıtılarak, derlem araçlarının çağdaş sözlü Türkçe gençlik dilinin çoklu etkileşimsel yönlerini incelemek için sunduğu olanaklar tartışılmaktadır. Bu makalenin Türkçe gençlik diline dair daha fazla dilbilimsel araştırma yürütülmesine dair motivasyon oluşturarak Türkçe gençlik dilini araştırmak ve tartışmak için hesap verebilir ve tutarlı metodolojileri benimseyen sistematik çalışmaların önünü açması hedeflenmektedir.
The Formation of In-Betweennees: Iraqi Immigrants' Identity in Heather Raffo's Noura
Authors: Saad Asmaa Mohanad , Khalil Marwa Ismail
Published: December 2024

: Heather Raffo, an Iraqi American playwright, focuses on Iraqi immigrants’ issues and offers a glimpse into their lives by narrating their stories in her plays. Raffo’s drama falls under the category of immigrant literature in which immigrants or their descendants are usually presented. In Noura (2019), Raffo depicts the story of a Christian Iraqi family who fled to the United States to avoid ISIS, a dangerous radical Islamic group. Raffo’s Noura describes the notion of in-betweenness through its characters’ dimensions. Depending on postcolonial theories, this paper analyzes and elucidates the situation of the Iraqi immigrants who fluctuate between the two different cultures of their homeland and their adoptive country. Moreover, this paper highlights how Iraqi immigrants occupy the place of in-betweeness and their in inability to forget their cultural belonging. Depending on Homi Bhabha’s mention of the term ‘in-between’ space to refer to the ‘third Space,’ the Iraqi immigrant characters in Noura designate a transcultural contact zone, hybrid or ‘in-between' space in which they initiate new signs of identity formation. The paper portrays how the cultural encounter causes a sense of confusion among the immigrants and how it affects the construction of their in-between or multicultural identity. Hereby, Noura’s characters develop a new mixed form in which the boundaries between their Iraqi identity and their American identity are blurred and fluid.
Relationship between vitamin D deficiency and gestational diabetes: a narrative review
Authors: Lin Caiqiong , Liu Haiwei
Published: December 2024

Vitamin D, often referred to as the “sunshine vitamin,” is an essential fat-soluble vitamin that plays a critical role in bone health and has been shown to improve insulin sensitivity and glucose tolerance. Vitamin D deficiency is prevalent among pregnant and pre-pregnancy women, which increases the risk of developing gestational diabetes mellitus (GDM), a common complication during pregnancy. Recent studies have explored various aspects of the relationship between vitamin D deficiency and GDM, including the mechanisms by which vitamin D affects glucose metabolism, the role of the vitamin D receptor gene, and the impact of routine vitamin D supplementation before and during pregnancy. This paper will review the current research progress in these areas.
High density of TCF1+ stem-like tumor-infiltrating lymphocytes is associated with favorable disease-specific survival in NSCLC
Authors: Førde Dagny , Kilvær Thomas , Pedersen Mona Irene , Blix Egil S , Urbarova Ilona , Paulsen Erna-Elise , Rakaee Mehrdad , Busund Lill-Tove Rasmussen , Donnem Tom , Andersen Sigve
Published: December 2024

Introduction

Tumor-infiltrating lymphocytes are both prognostic and predictive biomarkers for immunotherapy response. However, less is known about the survival benefits oftheir subpopulations.

Methods

Using machine learning models, we assessed the clinical association of the CD8+, PD1+, TCF1+ cel l subset by multiplex immunohistochemistry using tissue microarrays in 553 non-small cell lung cancer (NSCLC) patients and its correlation with other immune cell biomarkers.

Results

We observed positive correlations between TCF1 and CD20 (r=0.37), CD3 (r=0.45)and CD4 (r=0.33). Notably, triple positive (CD8+PD1+TCF1+) were rare, only observed in 29 of 553 patients (5%). Our analysis revealed that cells coexpressing TCF1 with either CD8+ or PD1+ were independent prognostic markers of disease-specific survival in multivariable analysis (HR=0.728, p=0.029 for CD8+TCF1+, and HR=0.612, p=0.002 for PD1+TCF1+). To pilot the subtype of abundant CD8-TCF1+ cells, we explored an immune cell infiltrated whole slideimage and found the majority to be CD4+.

Discussion

Overall, these findings suggest that assessment of CD8+, PD1+, TCF1+ could serve as a potential prognostic biomarker in NSCLC.
Mechanisms underlying the involvement of peritoneal macrophages in the pathogenesis and novel therapeutic strategies for dialysis-induced peritoneal fibrosis
Authors: Wang Yangwei , Zhang Yixian , Ma Mingqi , Zhuang Xiaohua , Lu Yue , Miao Lining , Lu Xuehong , Cui Yingchun , Cui Wenpeng
Published: December 2024

Long-term exposure of the peritoneum to peritoneal dialysate results in pathophysiological changes in the anatomical organization of the peritoneum and progressive development of peritoneal fibrosis. This leads to a decline in peritoneal function and ultrafiltration failure, ultimately necessitating the discontinuation of peritoneal dialysis, severely limiting the potential for long-term maintenance. Additionally, encapsulating peritoneal sclerosis, a serious consequence of peritoneal fibrosis, resulting in patients discontinuing PD and significant mortality. The causes and mechanisms underlying peritoneal fibrosis in patients undergoing peritoneal dialysis remain unknown, with no definitive treatment available. However, abnormal activation of the immune system appears to be involved in altering the structure of the peritoneum and promoting fibrotic changes. Macrophage infiltration and polarization are key contributors to pathological injury within the peritoneum, showing a strong correlation with the epithelial-to-mesenchymal transition of mesothelial cells and driving the process of fibrosis. This article discusses the role and mechanisms underlying macrophage activation-induced peritoneal fibrosis resulting from PD by analyzing relevant literature from the past decade and provides an overview of recent therapeutic approaches targeting macrophages to treat this condition.
Mitogenomic analysis reveals the phylogenetic placement of monotypic Parachelon grandisquamis and distinctive structural features of control regions in mullets
Authors: Yoon Tae-Ho , Kang Hye-Eun , Aini Sarifah , Wujdi Arief , Kim Hyun-Woo , Kundu Shantanu
Published: December 2024

Introduction

The large-scale mullet, Parachelon grandisquamis (Teleostei: Mugilidae), is a monotypic species endemic to the eastern Atlantic Ocean, playing a crucial role in tropical ecosystems. Despite its ecological significance, the systematic classification of Mugilidae remains unresolved, largely due to their diverse morphology, which necessitates the integration of molecular data.

Methods

This study aimed to achieve a comprehensive molecular characterization of the species and establish its matrilineal taxonomic placement using complete mitogenome data. Next-generation sequencing was employed to generate the de novo mitogenome of P. grandisquamis, which spans 16,859 bp and includes 13 protein-coding genes (PCGs), 22 transfer RNAs, two ribosomal RNAs, and a non-coding AT-rich control region (CR).

Results

Most PCGs use ATG as the start codon, with the exception of COI, which begins with GTG. Analysis of amino acids abundance revealed high frequencies for leucine, serine, proline, threonine, and alanine with distinctive codon usage. The proportion of nonsynonymous and synonymous substitutions suggests strong purifying selection in most PCGs, except for ND4L, ND5, and ND6. Most transfer RNAs exhibited typical cloverleaf secondary structures, with the exception of tRNA-Ser1 (GCT), which lacks base pairing in the DHU arm. Mitogenome-based phylogenetic analysis using the Bayesian approach revealed that the monotypic P. grandisquamis is closely related to the genera Chelon and Planiliza within Mugilidae. Furthermore, analysis of the CRs with polymorphic nucleotides in conserved blocks provides additional insight into the development of distinct molecular markers for species identification and population structure analysis of mullets.

Discussion

Overall, this study provides a comprehensive analysis of the mitogenomic structure and variation of P. grandisquamis and other mullets, confirming its maternal evolutionary relationships and offering valuable insights for advancing SNP-based species discrimination within the Mugilidae lineage.
The screening and anti-Raji lymphoma effect of Chiloscyllium plagiosum anti-CD20 VNARs
Authors: Ren Qingyu , Sheng Yu , Sun Ling , Zheng Feijian , Hu Chengwu , Chen Jianqing , Lyu Zhengbing , Yuan Chen , Jiang Xiaofeng
Published: December 2024

Introduction

B-cell lymphoma, a malignant proliferative disease originating from lymphoid tissue, poses a grave threat to human health. CD20 has emerged as a promising target for lymphoma treatment. However, due to the significant heterogeneity of B-cell lymphomas, conventional CD20 monoclonal antibodies show limited penetration, severely impeding the progress of B-cell lymphoma therapies.

Methods

In contrast, single-domain antibody molecules derived from cartilaginous fish have a molecular weight as small as 12 kDa, granting them robust penetration capabilities and making them the smallest known molecules of efficiently targeting specific antigens.

Results

As a result, these molecules hold tremendous potential as candidate drugs for lymphoma treatment. In this study, the whitespotted bamboo shark (Chiloscyllium plagiosum) was immunized with recombinant human CD20 to generate specific single-domain antibodies (sdAbs) targeting CD20. By utilizing phage display technology, the variable new antigen receptors (VNARs) were successfully screened and identified, and play an important role in the inhibition of Raji lymphoblastoma.

Discussion

The sdAbs obtained through this research represent promising candidates for B-cell lymphoma treatment, displaying significant potential for clinical applications and offering a new direction for the development of targeted therapies against lymphoma.
Development of 6-amido-4-aminoisoindolyn-1,3-diones as p70S6K1 inhibitors and potential breast cancer therapeutics
Authors: Thornton Adrian , Komati Rajesh , Kim Hogyoung , Myers Jamiah , Petty Kymmia , Sam Rion , Johnson-Henderson Elijah , Reese Keshunna , Tran Linh , Sridhar Vaniyambadi , Williams Christopher , Sridhar Jayalakshmi
Published: December 2024

Introduction

Many breast cancer therapeutics target the PI3K/AKT/mTOR oncogenic pathway. Development of resistance to the therapeutics targeting this pathway is a frequent occurrence. Therapeutics targeting p70S6K1, a downstream member of this pathway, have recently gained importance due to its critical role in all types of breast cancer and its status as a prognostic marker. We have developed a new class of p70S6K1 inhibitors that show growth inhibition of MCF7 breast cancer cells.

Methods

A series of 6-amido-4-aminoisoindolyn-1,3-dione compounds was developed against p70S6K1 using docking, computational modeling tools, and synthesis of the designed compounds. The p70S6K1 inhibition potency of the compounds was investigated in an initial high-throughput screening followed by IC50 determination for the most active ones. The best compounds were subjected to proliferation assays on MCF7 breast cancer cells. The targeting of p70S6K1 by the compounds was confirmed by studying the phosphorylation status of downstream protein rpS6.

Results

In this study, we have identified a new class of compounds as p70S6K1 inhibitors that function as growth inhibitors of MCF7 breast cancer cells. The structural features imparting p70S6K1 inhibition potency to the compounds have been mapped. Our studies indicate that substitutions on the phenacetyl group residing in the cleft A of the protein do not contribute to the inhibition potency. Three compounds (5b, 5d, and 5f) have been identified to have sub-micromolar inhibition potency for p70S6K1. These compounds also exhibited growth inhibition of MCF7 cells by 40%–60% in the presence of estradiol.
Influence of early-life stress on hippocampal synaptic and network properties
Authors: Rozov Andrei , Fedulina Anastasia , Krut’ Viktoriya , Sokolov Rostislav , Sulimova Arina , Jappy David
Published: December 2024

According to the World Health Organization, the number of people suffering from depressive disorders worldwide is approaching 350 million. The consequences of depressive disorders include considerable worsening of the quality of life, which frequently leads to social isolation. One of the key factors which may cause depression in adulthood is early life stress, in particular, insufficient maternal care during infancy. Studies performed with children raised in orphanages have shown that long-term complete absence of maternal care (chronic early life stress) leads to vulnerability to emotional disorders, including depression, in adulthood. All of the above dictates the need for a deep understanding of the mechanisms of the pathogenicity of stress in neurogenesis. Therefore, the consequences of stress experienced in the early stages of development are actively studied in animal models. A large body of evidence has accumulated indicating stress-induced changes in gene expression and behavioral disorders in adulthood. However, the connection between the molecular biology of neurons and complex behavior runs through the synaptic connections linking these neurons into complex neural networks. In turn, coordinated activity in neuronal ensembles, achieved by a balance of synaptic excitation and inhibition, is the basis of complex behavior. Unfortunately, the effect of stress on synaptic interactions of neurons remains poorly understood.
Revisiting the emerging pathosystem of rice sheath blight: deciphering the Rhizoctonia solani virulence, host range, and rice genotype-based resistance
Authors: Kalboush Zeinab A. , Mazrou Yasser S. A. , Hassan Amr A. , Sherif Ahmed , Gabr Wael E. , Ali Qurban , Nehela Yasser
Published: December 2024

Sheath blight, caused by Rhizoctonia solani AG1 IA, is a challenging disease of rice worldwide. In the current study, nine R. solani isolates, within the anastomosis group AG-1 IA, were isolated, characterized based on their macroscopic and microscopic features, as well as their ability to produce cell wall degrading enzymes (CWDEs), and further molecularly identified via ITS sequencing. Although all isolates were pathogenic and produced typical sheath blight symptoms the susceptible rice cultivar, Sakha 101, R. solani AG1 IA -isolate SHBP9 was the most aggressive isolate. The virulence of isolate SHBP9 was correlated with its overproduction of CWDEs, where it had the highest pectinase, amylase, and cellulase activity in vitro. R. solani AG1 IA -isolate SHBP9 was able to infect 12 common rice-associated weeds from the family Poaceae, as well as over 25 economic crops from different families, except chickpea (Cicer arietinum) from Fabaceae, Rocket (Eruca sativa) from Brassicaceae, and the four crops from Solanaceae. Additionally, rice genotype-based resistance was evaluated using 11 rice genotypes for their response to R. solani isolates, morphological traits, yield components, and using 12 SSR markers linked to sheath blight resistance. Briefly, the tested 11 rice genotypes were divided into three groups; Cluster “I” included only two resistant genotypes (Egyptian Yasmine and Giza 182), Cluster “II” included four moderately resistant genotypes (Egyptian hybrid 1, Giza 178, 181, and 183), whereas Cluster “III” included five susceptible (Sakha 104, 101, 108, Super 300 and Giza 177). Correspondingly, only surface-mycelium growth was microscopically noticed on the resistant cultivar Egyptian Yasmine, as well as the moderately resistant Egyptian hybrid 1, however, on the susceptible Sakha 104, the observed mycelium was branched, shrunk, and formed sclerotia. Accordingly, Indica and Indica/Japonica rice genotypes showed more resistance to R. solani than Japonica genotypes. These findings provide insights into its pathogenicity mechanisms and identify potential targets for disease control which ultimately contributes to the development of sustainable eco-friendly disease management strategies. Moreover, our findings might pave the way for developing resistant rice varieties by using more reliable resistance sources of non-host plants, as well as, rice genotype-based resistance as a genetic resource.