bluuebunny/crossref_metadata_2025 huggingface dataset:
DETERMINAN KETIMPANGAN PEMBANGUNAN EKONOMI DI KABUPATEN DAN KOTA PROVINSI KALIMANTAN TIMUR
Authors: Handoko Mukhammad Syarifudin Hidayatullah , Riyanto Wahyu Hidayat , Syaifullah Yunan
Published: April 2022

The purpose of this research is to know the influence of investment and regional expenditure on economic development disparity between Regencies and Cities in East Borneo Province during the period 2013-2018. The number of samples used 9 regencies/cities. The method used is a quantitative approach using panel data regression analysis technique. Data is processed through E-Views. Based on the research, it was found that the value of inequality that occurred in the districts and cities of East Kalimantan in 2013-2018 was classified as low, where the highest inequality value was 0.33 which occurred in the city of Samarinda which is the capital of the province of East Kalimantan, this value is low. The result showed that simultaneously investment and regional expenditure variabel had a positive and significant effect on the level of economic development inequality, as well as partially investment and regional expenditure variables had a positive and significant effect on the level of economic development inequality between regency and city of East Borneo Province during period 2013-2018.
Faktor-Faktor Yang Mempengaruhi Pendapatan Asli Daerah (PAD) per Kabupaten di Provinsi Nusa Tenggara Barat Tahun 2014-2018
Authors: Hikmahyanti Nuri , Soelistyo Aris
Published: April 2022

This study aims to analyze the factors that affect the Regional Original Income (PAD) per district in the province of West Nusa Tenggara. The variables used in this study are PAD, Total Population, GRDP, number of Industries, and Government Expenditures. The collection of data relating to the Total Population, GRDP, number of Industries, Government Expenditures, and Regional Original Income was obtained from BPS and DJPK in West Nusa Tenggara Province. The technique used in this study is panel data regression analysis using three methods, including the Common Effect Model, Fixed Effect Model, and Random Effect Model. The model chosen is the Common Effect Model. The results of this study indicate that the variables of Population, GRDP, number of Industries, and Government Expenditures have a significant effect on PAD.
Analisis Pengaruh Investasi, Pajak Daerah, Tenaga Kerja Terhadap Produk Domestik Regional Bruto Kabupaten/Kota Provinsi Jawa Timur Tahun (2015-2019)
Authors: Kusuma Septian Gilang , Wahyudi Muhammad Sri
Published: April 2022

The purpose of this study is to determine the effect of the variable Investment (PMDN), Regional Tax and Labor (Working Force) on the Gross Regional Domestic Product (PDRB-ADHK) in the Regency/City of East Java Province. The analytical tool used is panel data regression. From the results obtained, the value of the determinant coefficient R^2 for the model used is the Fixed Effect of 0.929335. Where it shows the dependent variable is 92.93%. So that the results of the study can be concluded that simultaneously Investment, Regional Tax and Labor have a positive and significant effect on Gross Regional Domestic Product (PDRB) with F statistic 48.65 greater than F-table. While the results of the partial test show that investment, local taxes and labor have a significant positive effect on Gross Regional Domestic Product (PDRB).
Analisis Faktor Penentu Pembiayaan Bank Syariah Di Indonesia
Authors: Anggarwati Desi , Zuhroh Idah
Published: April 2022

This study aims to analyze the determinants of financing in Islamic banking in Indonesia. The independent variables in the study are Third Party Funds (DPK), Return on Assets (ROA), Financing to Deposit Ratio (FDR), Minimum Capital Adequacy Requirement (KPMM), Non-Performing Financing (NPF_Gross), Against Islamic Commercial Banks in Indonesia. . The population used in this study were all Indonesian Islamic banking for the 2010-2020 period, namely 14 banks. The sample of this research is using 8 Islamic banking. With the sampling method, namely purposive sampling. The results of this study are that the third-party funds (DPK) have a positive and significant effect on Islamic bank financing. Return on Asset (ROA) has a negative and significant effect on Islamic bank financing. Financing to Deposit Ratio (FDR) has a positive and significant effect on Islamic bank financing. Minimum Capital Adequacy Requirement (KPMM) has a positive and insignificant effect on Islamic bank financing. Non-performing financing (NPF_Gross) has a negative and significant effect on Islamic bank financing.
ANALISIS LAYANAN GO-FOOD DALAM MENINGKATKAN PENJUALAN PADA UMKM KULINER DI YOGYAKARTA
Authors: Preasetianto Singgih , F. B. Mahda , Kusuma Dimas Martha , Cahya Agus Dwi
Published: April 2022

This study aims to identify and analyze natural go-food services to increase culinary sales carried out by GO-JEK in Yogyakarta. This study uses a quantitative approach with a sampling technique using probability sampling. The sample in this study is culinary in Yogyakarta which is done with go-food services. Testing of data instruments in this study uses validity, reliability, and classical assumption tests, while data processing uses simple linear regression. The results showed that the go-food service had a significant and significant effect on increasing culinary sales in Yogyakarta.
Abstract Book: 3rd National Seminar on Nanomedicine & Medical Devices in Healthcare, 11th Feb. 2022
Authors: ApeejayStya University SPS
Published: April 2022

I am delighted to know that School of Pharmaceutical Sciences (SPS), ApeejayStya University, Gurugram is going to organize 3rd National Seminar on ‘Nanomedicine & Medical Devices in Healthcare’ on 11th February, 2022 via hybrid mode funded by DST-SERB in collaboration with Martin & Harris Global, ASG BioChem, and Walter Bushnell.
Development and Evaluation of Medicated Chewing Gum Formulations of Ondansetron
Authors: Kumar Kapil , Adesh , , Teotia Deepak , Ikram ,
Published: April 2022

The objective of the present study was formulation and evaluation of medicated chewing gum formulations of Ondansetron.  Four medicated chewing gum formulations of Ondansetron were prepared by direct compression mould method. Formulations were characterized for physical evaluation, weight variation, stickiness, hardness/plasticity, in vitro drug release, and drug release study.  All the formulations gave satisfactory results in physical evaluation, weight variation, stickiness, and hardness. The formulation of batch F4 showed best in vitro drug release which is 60.68% in 25 min and it is also more accepted by the people. In conclusion, prepared formulations can be cost-effective product and also showed better compliance and increase in bioavailability.

Keywords: Chewing gum, Ondansetron, direct compression mould method, solid oral delivery systems
Relationship Between Mother's Level of Knowledge About Cervical Cancer in Performing Pap Smear Screening Tests in Kampung Rawa Panjang Bekasi in 2016
Authors: Nurprilinda Marliana , Gultom Moskwadina
Published: April 2022

Cervical cancer is the second most found cancer in women in Indonesia, and every year, there are at least 40.000 cases of it. Cervical cancer can be detected early with a Pap smear test. This research aims to determine the association of a mother's knowledge regarding cervical cancer on performing Pap smear screening tests. The method used in this research is analytic cross-sectional with a total sample of 77 respondents. The result obtained is that most of the respondents, 51,9%, lack knowledge of cervical cancer, and 66,2% of them disagreed with the concept and objected to Pap smear. The statistical test with Chi-square done on SPSS shows the p-value = 0,03, proving that the association of the mother's knowledge regarding cervical cancer with the performing Pap smear screening test is significant.

Keywords: Knowledge, Cervical Cancer, Pap Smear
An overview on Niosomes: Novel Pharmaceutical drug delivery system
Authors: Sharma Riya , Dua J.S. , Parsad DN
Published: April 2022

Over the years, researchers have attempted to improve the potency of medicament utilization for the treatment of a variety of diseases. Drug targeting is a phenomenon in which a drug is distributed in the body in such a way that it interacts with the target tissue at a cellular or sub-cellular level to achieve a desired therapeutic response at the desired site while avoiding unwanted interactions at other sites. This can be accomplished using modern drug delivery system targeting methods such as niosomes. Niosomes are a novel drug delivery system that encapsulates the medication in a vesicle. The vesicle is made up of a non-ionic surfactant bilayer. The particle size of the niosome must be in the range of 10 nm -100 nm. Niosomes are preferred over liposomes because they are more stable and less expensive. Niosomes enhance the pharmacological action of drug molecules by delaying the drug's clearance from circulation, protecting the drug from the biological environment, and limiting the effects to the target cells. It has applications in cancer treatment, as a carrier in hemoglobin, delivery of peptide drugs via the oral route, treatment of leishmaniasis, ophthalmic delivery, and as a carrier in dermal drug delivery. This review article focuses on the vesicular system's composition, benefits, types of niosomes, methods of preparation, characterization, and application.

Keywords: Niosomes, Composition, Types, Method of preparation, Characterization, Application.
Pharmacognostical Aspects and Phytochemical Screening of Powdered Rosa centifolia Petal
Authors: Singh Khushbu
Published: April 2022

Objective: This study would be useful to complement the information regarding pharmacognostical characteristics, physicochemical evaluation, micrometric analysis, and phytochemical exploration in the Ayurvedic system of medicine for its identiﬁcation and pharmacological use of herbal drug Rosa centifolia Petals.

Material and Methods: The ﬂowers of Rosa centifolia were collected, authenticated and shade dried. Rosa centifolia petals were then undergone morphological, physiochemical exploration, micrometric investigation, and Phytochemical analysis. The dried Rosa centifolia Petals were then extracted with different solvents alcohol, ethyl acetate, and petroleum ether, and their extractive values were calculated. The secondary metabolites were found in ethanol and ethyl acetate extract of the crude drug. Thin Layer chromatography (TLC) was performed for important phytochemicals flavonoids and polyphenol of the ethanol, ethyl acetate, and petroleum ether extract. The presence of Flavonoids and phenolics showed in various extracts with one spot in individual extracts of the crude drug.

Result and discussion: The Physicochemical evaluation of powder crude drug showed values for moisture content, ash values, swelling index, foreign matter, and extractive values which are within the limits of World Health Organization standards for medicinal plants. Micromeritic analysis of rose petal powder discloses good ﬂowability. The preliminary examination of the crude extract indicated the presence of carbohydrates, glycosides, alkaloids, ﬂavonoids, and amino acids. TLC Rf values for flavonoid and phenolic were found for ethanolic extract at 0.78 and 0.77, ethyl acetate extract at 0.81 and 0.78, and petroleum ether extract at 0.81 0.78 respectively.

Conclusions: The current study was to explore the crude drug that would be useful to complement the information regarding pharmacognostical features, physicochemical determination, micrometric exploration for the standardization of Rosa centifolia Petals.

Keywords: Rosa centifolia, Macromorphological study, Physicochemical exploration, Phytochemical analysis, micrometric investigation, TLC screening.
Drug Utilization Pattern of Anti-Diabetic Medication: A Prospective Observational Study
Authors: Linggi Celeste , Shukoor Fathima , Divya Raveendran , Kavyasree Ganne , Nyamagoud Sanat B , Mahendrakumar R B
Published: April 2022

Background: Diabetes mellitus is a chronic disease and is responsible for the significant morbidity and mortality. It is critical to conduct a drug use research of anti-diabetic medications in order to encourage rational drug use in diabetes.

Objective: The purpose of this study was to analyze the pattern of drug use of antidiabetic drugs, as well as the prevalence of diabetes and related risk factors throughout treatment period in our sample group.

Materials & methods: This is a prospective observational research involving 200 secondary care hospital in-patients. During a 6-month period, the prescribing pattern was studied and assessed, and drug-related difficulties in subsequent patients were report.

Results: Among 200 patients, 111 (55.46%) were male and 89 (44.5%) were female. Subject of age  65-80 (n=73) were observed to be more suspected. Hypertension 130 (61.32%) was the most common risk factors. In 200 cases, the most commonly used therapy was monotherapy in 89 subjects (44.5%) followed by combination therapy 55(27.5%). Insulin 192(54.5%) was most commonly used followed by oral drugs 160 (45.4%). The most usually prescribed monotherapy was metformin, followed by glimepiride, while the most commonly prescribed combination therapy were metformin+glimepiride.

Conclusion: Prescribing pattern of drugs in diabetic patients concluded that optimized drug therapy led to minimal ensuing DRPs. A continuous observation and reporting of the prescribing practice of anti-diabetic drugs can help the physicians result in therapeutically effective treatment for the patients.

Keywords: Antidiabetics, Drug utilization pattern, Drug related problem, Comorbidities, metformin
Comparison of the Use of Kinetic Model Plots and DD Solver Software to Evaluate the Drug Release from Griseofulvin Tablets
Authors: Ekenna Ifeoma Cynthia , Abali Sunday Okorie
Published: April 2022

Awareness of the release kinetics of active drugs is important in formulating drugs that have the desired delivery and in predicting the behaviour of the formulated drug in vivo. The study aims to determine the mechanism of drug release from griseofulvin tablets formulated with different surfactants using mathematical models and to compare the use of graphs and DD solver software in fitting dissolution profiles to kinetic models. The batches P1 -P3 were composed of the surfactant - PEG 4000 in different concentrations. A control batch without surfactant and a commercial brand (Mycoxyl 500) were used for comparison. Granule and tablet quality tests indicated quality formulations. Dissolution profiles showed that the surfactant improved drug release of griseofulvin and batches (batches P1 -P3) formulated with PEG 4000 had the best release profiles comparable with the commercial brand. The Excel Add-in DD solver and kinetic plots were used to determine the kinetic model of best fit. The Higuchi model was the best fit for batches P1 -P3. The first order and Hixon -Crowell also fit batches P2 and P3. The Korsmeyer’s model showed that batches P1 -P3 exhibited anomalous diffusion. The tablets formulated with PEG were as good as the commercial brand and they had an anomalous diffusion of the drug from the tablet; meaning that drug diffused following Fickian law and also diffused through a swollen and porous matrix. Kinetic plots and the DD solver can be used for fitting dissolution profiles to kinetic models.

Keywords: Griseofulvin, Kinetics, Models, Surfactants, Polyethylene glycol (PEG) 4000, DD solver, Dissolution profile, mathematical models
Phytochemical Screening, Antimicrobial and Antioxidant Activities of Aloe buettneri, Mitracarpus scaber and Hannoa undulata used in Togolese Cosmetopoeia
Authors: KOMBATE Bignoate , METOWOGO Kossi , KANTATI Yendube T. , Afanyibo Yaovi-Gameli , FANKIBE Nakpane , HALATOKO Afiwa Wemboo , Yao Sadji Adodo , Eklu-Gadegbeku Kwashie , AKLIKOKOU Kodjo A.
Published: April 2022

Background: Aloe buettneri, Mitracarpus scaber and Hannoa undulata are three plants species used in the Togolese traditional medicine to cure dermatosis. This study aims at assessing their anti-oxidant and anti-microbial activities on acne-developing micro-organisms.

Methods: Six micro-organisms including Cutibacterium acnes ATCC 6919, Pseudomonas aeruginosa ATCC 27853; Escherichia coli ATCC 25922; Klebsiella pneumoniae ATCC 700603; Staphylococcus aureus ATCC 29213; and Candida albicans ATCC 35659 were used. Inhibition diameter was assessed using the agar well diffusion method. Minimum inhibitory and minimum microbicidal concentrations have been achieved through the liquid dilution method. Anti-oxidant activities were evaluated by DPPH antiradical scaving and FRAP methods. Phytochemical screening was also realized.

Results: All the microorganism’s strains tested, excepted Candida albicans and Escherichia coli, were susceptible to plants extracts at 250 mg/mL in the agar well diffusion assay with inhibition diameters ranging from 12.10 ± 0.07 to 18.20 ± 0.10 mm. The MICs values were comprised between 15.625 mg/mL and 62.5 mg/mL, when MMCs ranged from 31.25 to 125 mg/mL. At the concentration of 500 µg/mL, the scavenging properties on DPPH radicals were 49.20 ± 0.15% for H. undulata, 41.29 ± 0.51% for A. buettneri, 59.57 ± 0.41% for M. scaber and 87.22 ± 0.03% for Quercetin. For FRAP assay, the effective concentration (EC50) of A. buettneri, M. scaber and H. undulata extracts were 977.44 ± 1.13 µg/mL; 267.74 ± 10.13 µg/mL and, 272.54 ± 12.87 µg/mL respectively while quercetin presented the EC50 of 48.63 ± 2.00 µg/mL. The antimicrobial and antioxidant activities of these species might be required to the presence of polyphenols, tannins, flavonoids, triterpenes, saponoside and alkaloids identified by phytochemical screening.

Conclusion: The three plants extracts are all potential natural antimicrobial and antioxidant candidates for treating acne vulgaris.

Keywords: Aloe buettneri, Mitracarpus scaber, Hannoa undulata, antimicrobial activity, antioxidant activity, phytochemical screening, Acne vulgaris
Application of Foot Exercises in Diabetes Mellitus Clients with Blood Glucose Levels Instability: A Case Study
Authors: Saprianto Saprianto , Khairunnisa Khairunnisa
Published: April 2022

Diabetes is a metabolic disorder caused by a lack of the hormone insulin in a person's body. Lack of the hormone insulin in a person's body. Lack of the insulin hormone causes the sugar (glucose) consumed by the body to be imperfect. This situation causes the patient to experience hyperglycemia or excess blood sugar. In diabetes, the condition of excessive blood sugar levels can result in long-term damage, dysfunction and failure of various organs, especially feces, kidneys, nerves, heart and blood vessels. This study aims to determine blood glucose levels before and after the application of foot exercises. With the method of writing in this study using data collection methods, with 2 clients affected by Diabetes Mellitus. The tool used to measure blood glucose is using a glucometer. The results showed that management to overcome instability of blood glucose levels in clients with diabetes mellitus can be done by applying foot exercise techniques. From this study it can be concluded that there are changes in blood glucose in diabetes mellitus clients before and after implementing foot exercises. The application of diabetic foot exercises can be used to improve blood circulation in the legs and prevent swelling and injuries to the feet. Further researchers are advised to increase the number of respondents so that they can reduce blood glucose levels more from this study

Keywords: Diabetes mellitus, blood glucose levels, foot exercise
Metagenomics Analysis of Breast Cancer to Study Bacterial Diversity
Authors: Jain Muskan , Yadav Ruchi
Published: April 2022

Introduction: Breast cancer is the swelling structures in the breast cells. After skin cancer, breast cancer is the most broadly accepted malignancy analysed in ladies in the United States. Breast cancer can happen in both males and females, yet it's undeniably more normal in ladies. Indications of mammary glands cancer may involve a ball or lumps in the breast, an alteration of breast shape, scratching of the skin, fluid coming out from areola, a recently reversed areola, or a red or textured fix of skin. In those with removed lay out of the illness, there can be bone agony, swollen lymph hubs, windedness, or yellow skin. There are certain microorganisms that are involved in breast cancer and have function thereof. The study of these microorganisms can be done through metagenomics study and comparing with normal samples.

Methods: For current study pairwise metagenomics data for breast cancer sample was retrieved from ENA site. Four FASTQ files were retrieved with the Accession no PRJEB25419 and complete metagenomics analysis was done using GALAXY Server. Tools like FASTQC, Trim galore, KRAKEN2, Krona pie chart etc. were used for classification and identification of microorganisms in the samples.

Results: The taxonomic and functional analysis of the metagenome of breast cancer identifies different organisms like. Actinobacteria, Bifidobacterium cuniculi, Murnine leukemia virus, Human endogenous retrovirus, Pezizomycotina. Different microbes and their percentage in the breast cancer have been predicted that are 4% of Nematocera, 2% of Brachycera, 3% of Galegeae, 2% of Nelumbo nucifera.

Conclusion These results give insights into the metagenome of breast cancer that can be used for clinical perspectives. Detailed study is required to establish the association of these microbes with development and progression of breast cancer.

Keywords: - Breast cancer, Metagenomics, Galaxy, ENA Database, Krona pie chart.
Quality By Design: A Review
Authors: Savitha S , Devi K.
Published: April 2022

Quality by Design is the most recent quality-related trend in pharmaceutical manufacturing (QbD). This paper discusses Pharmaceutical Quality by Design (QbD) as a way to guarantee high-quality pharmaceuticals. Details about Quality by Design are given in addition to a list of its components. The quality parameters and attributes of each unit operation are unique. Pharmaceutical products can benefit from Quality by Design and the steps that can be taken to implement it. High-quality pharmaceuticals and their manufacturing processes form the core of pharmaceutical R&D. It is impossible to verify the quality of a product because this document includes a breakdown of the product's quality profile and the most important aspects of Quality by Design. Comparing the quality of various products can be done in two ways: through Quality by Design and end-product testing (QbD). Quality by Design is based on the ICH Guidelines. ICH guidelines govern the development of pharmaceuticals and the implementation of quality assurance systems. Pharmaceutical development and production can benefit from Quality by Design (QbD).

Keywords: Concept & background of QbD, Traditional vs QbD Approach, Key elements, PAT, Challenges, Current & Future perspective.
Análisis de la pesca española en el Atlántico noreste 1980-2012: Papel de Galicia en la explotación de las principales especies marinas
Authors: Biton Porsmoguerador Sebastián
Published: April 2022

The Spanish fishing fleet is one of the most important in the European Union and is exploiting marine resources in the FAO area 27 (North-eastern Atlantic Ocean). The Galician Region has a relevant role in the fishing industry. The number of boats decreased significantly between 1980 and 2012. But the landing quantities of the main marine species exploited (small pelagic fishes and tuna species mainly) decreased faster that the fleet during the same period. In contrast, landing quantities of Elasmobranchs (sharks and rays) and Cephalopods increased. This analysis shows the overexploitation of the Atlantic fishing grounds.
Permeable frontiers in the open sea: The case of Swordfish in the Atlantic Ocean
Authors: Rubio Carlos J. , Macías David , Fernández Ignacio L. , Báez José C.
Published: April 2022

There is a vivid debate about the border location between North and South Atlantic swordfish stocks. Climate oscillations, East Atlantic (EA) and North Atlantic Oscillation (NAO), have a major impact on the Northern Hemisphere climate and weather conditions. The initial hypothesis of present study is that if it is considering the southern frontier, each stock will be differentially affected by both climatic oscillations, which would imply the existence of a strong border. However, a similar effect on both sides of the border would result in a permeable barrier. The results suggest that the combined effects of EA and NAO affect both the North and the South Atlantic swordfish stocks in similar ways, and consequently, the location of the border may reside farther north than the current management boundary at 5ºN.
Vertical distribution of macrobenthic communities from a shipwreck in the Strait of Magellan
Authors: Velasco-Charpentier Catalina , Pizarro-Mora Felipe , Navarro Nelso P. , Morales-Torres Diego F. , Valdivia Nelson
Published: April 2022

Shipwrecks are artificial reefs that can enhance local diversity. In this study, the macrobenthic community associated with a shipwreck in the Strait of Magellan, the DAP Mares, is described for the first time. Species richness and functional group richness were estimated, and general linear models were used to test the prediction that diversity varied systematically with depth. The most speciose and abundant groups were echinoderms, molluscs, sponges, and tunicates. The most abundant trophic type was suspension feeders. Species richness changed significantly with depth, being similar between the upper and middle zones but decreasing at the deepest zone. Neither functional group richness nor functional dispersion (Rao’s quadratic entropy) varied with depth, suggesting that not all aspects of macrobenthic diversity respond equally to this variable. The biodiversity observed was consistent with that described for natural hard substrates in the Strait of Magellan. Thus, this vessel could represent a good model to study patterns of community structure.
Functional status of Russian regions in the system of economic federative relations
Authors:   The Russian Presidential Academy of National Economy and Public Administration, Korotina Natalya
Published: April 2022

Introduction. The article deals with the problem of the functional status of regions in the system of economic federalism, which is associated with the high spatial heterogeneity of Russia, and explains the need to move from the model of economic fed- eralism, which combines the presence of universal institutions and institutional exceptions, to a model that takes into account the spatial diversity of ter- ritories. The purpose of the study is to substantiate the decrease in the heterogeneity of the economic federalism space when moving on to a model based on macro territories - groups of regions with the same functional status. Methods. The author uses methods of a mono- graphic review, logical and statistical analysis in the context of applying a spatial approach in studying the relations of economic federalism, as well as the concept of “smart specialization” in relation to the regions of Russia to differentiate the relationship of the federal center with the territories within the same specialization. Scientific novelty of the study. The article is the first to present a methodology for determining the functional status of regions, which is the basis for the subsequent formation of a model of relations between the federal center and macro regions. Results. The author proposes methods for deter- mining the functional status of regions and calcu- lating indicators that characterize the relations of economic federalism. The first methodology, based on economic and territorial criteria, makes it possi- ble to attribute each region of Russia to a group of macro regions according to their functional status. The second method makes it possible to substanti- ate a greater asymmetry of indicators character- izing economic federalism in the country as a whole than in the context of macro territories. Conclusions. Regarding the higher stability of indicators characterizing economic federalism by groups of macro-territories than in the country as a whole, the need for a transition to a flexible model of economic federalism based on differentiated measures and specific tools to support regions in the context of their functional specializations is substantiated.
LEGAL CUSTOM AS A SOURCE OF LAW
Authors:   Воронежский государственный университет, Воронеж, Россия, Юлия Владимировна Сорокина ,   Воронежский филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Воронеж, Россия
Published: April 2022

This article presents a study of legal custom as a source of law. The relevance of this problem is substantiated. The question of the essence of custom, its legal nature, which consists in the peculiarities of the way of regulating social relations by custom, is clarified. The questions of the origin and formation of legal customs are investigated. In particular, theories of the origin of customs are considered: the theory of spontaneous education and the theory of individual creativity. The correlation of custom and judicial precedent, custom and law is also analyzed, the viability of custom in the conditions of the state is proved.
DEVELOPMENT OF THE NORM: ANALYSIS OF THE NATURE OF THE NORM AS THE BASIS FOR AN INTEGRATIVE UNDERSTANDING OF LAW, AN INTEGRATIVE EFFECT AND A TRANSFORMED FORM IN THE THEORY OF LAW
Authors:   Южно-Российский институт управления – филиал Российской академии народного хозяйства и государственной службы при Президенте РФ, Ростов-на-Дону, Россия, Дмитрий Александрович Леусенко
Published: April 2022

The article is devoted to the presentation of the main paradigms and theoretical constructions of legal understanding that expand the understanding of the content of the integrative nature of law, the integrative understanding of law. The role of the transformed form of sociogenesis for the formation of the nature of law and the theoretical construction of an integrative legal understanding is characterized.
CIVIL-PATRIOTIC ACCENTS OF SEPARATE SOCIAL SPACES OF THE RUSSIAN FEDERATION AND THE PEOPLE'S REPUBLIC OF CHINA
Authors:   Пятигорский государственный университет, Пятигорск, Россия, Майя Арташесовна Аствацатурова ,   Хэйлунцзянский институт иностранных языков, Харбин, Китай, Сяоянь Лю ,   Хэйлунцзянский институт иностранных языков, Харбин, Китай, Сяоянь Лю ,   Хэйлунцзянский институт иностранных языков, Харбин, Китай
Published: April 2022

Comparative studies of socially significant spaces of the Russian Federation and the PRC make sense in methodological assessments of the transforming, reforming polities in identifying general and differentiated politically determined tendencies and patterns. The article analyzes the resources of the patriotic idea as an integrative basis for structuring the administrative and educational socially significant spaces of Russia and China, highlights popular techniques and technologies for the formation of patriotic consciousness in society in general, and student youth, in particular.
GENERATIONAL FEATURES OF PERCEPTION OF PROFESSIONAL DYNASTIES BY ROSTOV-ON-DON MEDICAL WORKERS
Authors:   Южный федеральный университет, Ростов-на-Дону, Россия, Юлия Сергеевна Панфилова
Published: April 2022

Formation of evaluative perception of professional dynasties is a process determined by a wide range of factors such as the degree of openness in the socio-professional structure, public policy and the state of professional affairs. Based on the survey results of the Rostov-on-Don city doctors, the article attempts to explain this perception in medicine from generational perspective. As the study prompts, evaluative perception of professional dynasties lay in the plane of dynasty as a mechanism of succession and dynasty as a way of monopolizing social positions. According to the findings, negative gradations in the total share of evaluations increase as the respondents’ age cohort decreases. This is, first of all, due to the conditions of initial professional socialization of different generations of doctors. Secondly, it forms on the difference in the volume of cultural, social and symbolic capital, which allows the older generations of doctors to reduce the destructive effects of dynasty.
TRIPLE HELIX THEORY AS THE CONCEPTUAL PLATFORM FOR INNOVATIVE TALENT CULTIVATION IN DIGITAL ECONOMY
Authors:   Хэнаньский университет экономики и права, Чжэнчжоу, Китай, Чуньлэй Чжан
Published: April 2022

The university-industry-government triple helix theory originated from regional innovation practices, revealing the essence of continuous knowledge-based regional innovation and triggering the exploration of new models and mechanisms for regional growth in countries around the world. The triple helix theory provides a new paradigm for the collaborative development of innovation and entrepreneurship education by government, enterprises, universities and other subjects. Taking the triple helix theory as a tool, the article proposes that under the background of digital economy, a new path of deep integration of innovation and entrepreneurship education with professional education should be explored in multiple modes, such as conceptual integration, curriculum integration and cross-disciplinary integration. University students are the main human base of the innovation and entrepreneurship group. To build the innovation and entrepreneurship education system in universities and to optimize the structure of innovation and entrepreneurship education, it is necessary to innovate the entrepreneurship model in universities based on the needs of the digital era.
POTENTIAL OF THE MARKET OF COMPOSITE MATERIALS IN THE RUSSIAN FEDERATION
Authors:   Национальный исследовательский Томский государственный университет, Томск, Россия, Егор Николаевич Голубничий
Published: April 2022

This article examines the composite materials market in the Russian Federation. Composite market research is essential to understand the challenges, benefits, and delineate market development paths. The share of Russia in the global production volume in value terms is still insignificant. Given the low level of production of composite materials and the high level of their consumption in a modern economy, the protectionist policy of the Russian Federation in this area is advisable, which will be justified both economically and politically.
Comparative QSAR modeling of 2-phenylindol derivatives for predicting the anticancer activity using genetic algorithm multiple linear regression and back-propagation-artificial neural network techniques
Authors: Bahrami Samira , shafiei fatemeh , Marjani Azam , Isfahani Tahereh Momeni
Published: April 2022

Quantitative structure-activity relationship (QSAR) studies on a series
of 2-phenylindole derivatives as anticancer drugs were performed to
choice the important molecular descriptor which is responsible for their
anticancer activity (expressed as pIC50)). The geometry optimizations
were performed on the structures using Gaussian 09W software with the
density functional B3LYP and 6-311G(d,p) basis sets . Dragon 5.4
software was used to calculate molecular descriptors, and the genetic
algorithm (GA) procedure and backward regression were used to proper
selection of the most relevant descriptors. Different chemometric tools
including the backward multiple linear regression (BW- MLR) and
backpropagation-artificial artificial neural network (BP-ANN) were
carried out to design QSAR models. The squared correlation coefficient
(R2) and the Root Mean Squared Error (RMSE) values of the GA-MLR model
were calculated to be 0.2843 and 0.7001 respectively. The BP-ANN model
was the most powerful, with the square of predictive correlation
coefficient R2pred, root mean square error (RMSE), and absolute average
deviation (AAD) which was equal to 0.9416, 0.0238, and 0.0099,
respectively. The external validation criteria (Q2F1, Q2F2, Q2F3, and
concordance correlation coefficient were applied to assay predictive
efficiency of QSAR model derived by BP-ANN method. The results derived
from the BP-ANN indicated that the anticancer activity of 2-phenylindole
derivatives depends strongly on 3D descriptors namely Radial
Distribution Function (RDF) descriptors and 3D-molecular geometry of the
studied compounds play an important role for these activities. Thus, it
could be useful in the design of new 2-phenylindole derivatives having
anticancer potency.
Cerulean cataract: a rare entity
Authors: maalej yosra , Kharrat Malek , Zinelabidine Mohammed Karim , Walid Zbiba
Published: April 2022

Cerulean or blue-dot cataracts is a rare entity caracterised by the
presence of early onset bilateral cataracts with concentric layers of
bluish-white opacities. Visual acuity is usually well preserved and
rarely necessitates cataract extraction before adult life.
Coronary artery obstruction during mitral valve surgery and concomitant left atrial appendage exclusion; choosing a culprit.
Authors: Gerdisch Marc W.
Published: April 2022

This letter is in response to the case report by Kuzmin et al. entitled
“Left atrial appendage occlusion device causing coronary obstruction: A
word of caution” , published in November 2020 issue of Journal of
Cardiac Surgery. The report describes a circumflex lesion occurring
following mitral valve (MV) repair, tricuspid valve repair, and left
atrial appendage closure (LAAO) using AtriClip device. The authors
concluded that LAAO is a safe procedure, but in the setting of a
concomitant MV surgery LAAO may be a contributor to the reported event.
Circumflex coronary artery occlusion or impingement during MV repair is
well described in the literature. On the reported two-dimensional cine,
the position of the stenosis is typical of mitral repair induced injury.
A ring suture can gather and compress tissue adjacent to the coronary
creating stenosis without a discrete ligation. It is also true that
vigorous traction on the LAA without due attention to distortion of the
adjacent circumflex might be capable of creating compression or
accordioning of the vessel. To mitigate this, the clip should be placed
at the true base of the appendage. A residual pouch carries as much or
more risk as not attempting to close the appendage at all. The authors’
recommendation to place the clip more distally will inevitably lead to
incomplete closures. In conclusion, the reported event was more likely
due to a mitral stitch, the path of which is not directly visualized
after it breaches the endocardium.
Extracorporeal Life Support Associated with Cardiac Procedures in Patients with Malignancy
Authors: Suzuki Yota , Carvalho Juliano Lentz , Mao Rui-Min D. , J Nicholas Iglesias , Shah Nikhil R. , Jr. Abe DeAnda, , Radhakrishnan Ravi S.
Published: April 2022

Objectives: With an aged population, cardiac surgery in
oncologic patients is no longer uncommon. The use of postcardiotomy
extracorporeal life support has increased, but its utility in oncologic
patients is not clear. This study aims to define the role of
postcardiotomy extracorporeal life support in patients with malignancy.
Methods: The Extracorporeal Life Support Organization registry
was queried for patients older than 18 years with an International
Classification of Diseases codes of hematologic and solid malignancy
over the last decade (2010-2019). Among them, patients who underwent
cardiac surgery or transcatheter valve intervention were selected.
Outcomes and clinical data including types of procedure and cancer
subtypes were analyzed. Results: One hundred and sixty-two
patients met inclusion criteria: 17 pulmonary support, 119 cardiac
support, and 26 extracorporeal cardiopulmonary resuscitation. Sixty-two
patients (38.3%) survived to discharge. Low survival was seen with
hematologic (35.5%), soft tissue (25.0%) and breast malignancies
(15.4%) though none of them were statistically significant. Coronary
artery bypass grafting (n=56) and surgical valve procedure (n=54) were
dominant types of procedures with a survival of 44.6% and 33.3%,
respectively. Ventricular assist device procedure (n=48) and cardiac
transplant (n=21) were also commonly performed with a survival of 37.5%
and 33.3%, respectively. Conclusions: Postcardiotomy
extracorporeal life support in patients with malignancy was associated
with a low but acceptable survival rate given the high mortality with
postcardiotomy extracorporeal life support in the general population.
The impact of a cancer diagnosis appeared to be small, but gathering a
detailed history of cardiotoxic treatments could be crucial.
Patching an Aortic Tear Using the Side-Arm and Surrounding Skirt of a Physician-Modified Ascending Aortic Graft
Authors: Mitchell William , Mehaffey Hunter , Kern John , Yount Kenan
Published: April 2022

Background: Aortic complications, such as aortic tears and
dissections, during cannulation must be managed urgently and often
require hypothermic circulatory arrest. We report a unique management
strategy to repair an aortic tear without dissection by modifying a
Dacron ascending aortic graft with side-arm to serve both as a patch for
the aortic tear and inflow for the bypass circuit. Case
Presentation: A 32-year-old female patient undergoing reoperative
cardiac surgery suffered an unexpected aortic tear during cannulation
for cardiopulmonary bypass. After promptly transitioning to femoral
cannulation and hypothermic circulatory arrest, the tear was repaired by
utilizing a physician-modified ascending aortic graft with side-arm, in
which the surrounding skirt of the side-arm was cut from the
circumferential graft to patch the defect. The patient was rewarmed with
the side-arm serving as arterial inflow for the bypass circuit, and the
remainder of the operation proceeded without complication.
Conclusion: This type of aortic repair for aortic tears without
dissection can offer the patient the benefit of avoiding multiple
aortotomies in a weakened aorta, reducing circulatory arrest time, and
re-establishing a central cannulation strategy for cardiopulmonary
bypass, consequently reducing the likelihood of distal limb ischemia.
Existence of solutions for anisotropic parabolic Ni-Serrin type equations originated from a capillary phenomena with nonstandard growth nonlinearity.
Authors: Ayazoglu(Mashiyev) Rabil , Akkoyunlu Ebubekir , Naghizadeh Zohreh
Published: April 2022

We consider an initial boundary value problem for a class of anisotropic
parabolic Ni-Serrin type equations with nonstandard nonlinearity in a
bounded smooth domain with homogeneous Dirichlet boundary condition.
Because the nonlinear perturbation leads to difficulties (it does not
have a definite sign) in obtaining a priori estimates in the energy
method, we had to modify the Tartar method significantly. Under suitable
assumptions, we obtain the global existence, decay, and extinction of
solutions.
Rhinovirus: a high-morbidity pathogen in predisposed patients
Authors: Hidalgo Irene Comino , Fernández Laura García , Carretero Cristina Núñez , Alonso Sara Bellón , Cimadevilla Juan Luis Rodríguez , Pequeño Javier López
Published: April 2022

In conclusion, we present the case of a 23-month-old boy with severe
recurrent respiratory exacerbations associated with Rhinovirus
infection. Thorough testing ruled out known risk factors such as
congenital anomalies, immune deficiency or coinfections. A genetic
analysis was performed, which failed to determine the presence of known
genetic determinants of human RV susceptibility. There are few studies
regarding the possible genetic mutations which increase the risk of
severe respiratory exacerbations and respiratory failure secondary to
viral infections, especially those involving human RV. A deeper
understanding of these mutations would improve our knowledge and help
identify at-risk patients with similar phenotypes to our case.
Fracture-based prediction of high-cycle fatigue lifetime in heat-treated AZ91/AZE911 magnesium alloys using striations spacing and Paris crack growth rate
Authors: Azadi Mohammad , Oliya Ahmad Yousefi Parchin , Parast Mohammad Sadegh Aghareb , Mokhtarishirazabad Mehdi
Published: April 2022

The fractographic analysis of the fracture surface is one solution to
determine the kind of failures and predict the fatigue lifetime and
resistance of mechanical components under cyclic loading. In the present
research, the fracture behavior of the AZ91 magnesium alloy, under
stress-controlled high-cycle fatigue loading, was analyzed based on the
fatigue striations on the fracture surface. At first, equations and
relations were extracted with the Paris crack growth law and the space
of the fatigue striations. Then, striation spacing was measured by the
experimental results of the high-cycle fatigue (HCF) testing for
heat-treated Mg-Al-Zn alloys, containing and non-containing rare earth
elements. Finally, constants of the Paris law were calculated and
calibrated. Results showed that rare earth elements addition decreased
the space between the striations, and subsequently, the fatigue
resistance of the AZ91 alloy increased. The reasons are extreme grain
size reduction by heat-treating and formation of new Al
RE phase by rare earth elements
addition. The obtained results of the predicted fatigue lifetime, in
comparison to the experimental ones, the scatter band of ±1.5X
demonstrated the accuracy of the recommended model by a mean error of
33%.
The Effect of Beta-blocker Use on Left Ventricular Strain Parameters in Echocardiography in Patients with Myocardial Bridge
Authors: YURDAM Ferhat S. , Gürses ECEM
Published: April 2022

Objectives: In this study, it was aimed to evaluate the effect
of beta-blocker use on left ventricular global longitudinal strain (LV
Gls) in echocardiography in patients with MB (Myocardial Bridge).
Patients and methods: A single-center study was conducted
prospectively in which patients with coronary angiography were performed
and myocardial bridging was detected between January 2019 and February
2022. A total of 100 patients (38 females, 62 males; mean age: 57.3±9.6
years; range, 32-75 years) with myocardial bridging were recruited
consecutively and strain echocardiography was performed.
Results: All patients in our study were followed in sinus
rhythm, and there was a statistically significant difference in mean
heart rate between groups I and II (p<0,001). LV Gls was found
to be statistically significant in favor of group II in the comparison
of group I [(-12,57)±3 vs. (-15,92)±2,9] and group II
(p<0.001). Conclusion: LV Gls is positively affected
in echocardiography thanks to the negative chronotropic effect obtained
with beta-blocker therapy in patients with MB detected in coronary
angiography.
'Ioυδαíα in the Geographical List of Acts 2:9–11 and Syria as "Greater Judea"
Authors: HENGEL MARTIN
Published: April 2022

The appearance of 'Ioυδαíα in the geographical list presented in Acts 2:9–11 has puzzled interpreters almost from the time of the publication of the book of Acts. It will be argued that this word should be retained in the text and should be understood in the light of traditional and especially messianic ideas about the extent of the promised land. The close association of Judea and Syria is especially important for understanding the meaning of 'Ioυδαíα in Acts 2:9–11.
The Function of LXX Habakkuk 1:5 in the Book of Acts
Authors: WALL ROBERT W.
Published: April 2022

This case study of Scripture's intertextuality follows the route of LXX Hab 1:5 through the Acts of the Apostles, from Paul's citation of it in climaxing his inaugural (and programmatic) sermon (Acts 13:41), to its intra-/intertextual echo in Acts 15:3. Its function in Acts 13:41 underscores the redemptive importance of Paul's "report" of God's "work" among the Gentiles: to dispute the prophet's "report" (ἐκδιηγέομαι) is to reject God's bid to save God's people. When Paul's travel "report" (ἐκδιηγέομαι, 15:3) of his Gentile mission is again disputed by Jewish believers in Antioch (15:1) and Jerusalem (15:5), their eternal life is threatened according to biblical prophecy.