bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnostic performance of abdominal CT for diagnosis of pelvic fractures: comparison with pelvic CT
Authors: Yun Seong Jong , Jin Wook , Yoon So Hee , Chun Young Soo , Cha Jang Gyu , Koo Hye-Soo , Park So Young , Park Ji Seon , Ryu Kyung Nam , Lee Sun Hwa , Shin Jong Soo
Published: January 2016

Background

In the emergency department, patients with abdominopelvic trauma inadvertently undergo both abdominal computed tomography (CT) (for intra-abdominal and intra-pelvic organs) and pelvic CT (CT with multiplanar reformation in three orthogonal planes of the bony pelvis). However, the systemic use of CT is concerning given the cumulative radiation dose.

Purpose

To evaluate the diagnostic value of abdominal CT in comparison to pelvic CT in patients with suspected pelvic fractures.

Material and Methods

Seventy-two patients who underwent abdominal CT and pelvic CT within a 2-week period to evaluate pelvic fractures were included. Two reviewers retrospectively analyzed eight anatomical regions of the pelvic bones on both abdominal CT and pelvic CT over a 1-week interval. The interpretation of pelvic CT scans by two senior musculoskeletal radiologists was considered as the reference standard. Diagnostic performance and inter-observer agreement of both CT scans were evaluated.

Results

For reviewers 1 and 2, abdominal CT showed high accuracy (98% and 98%, respectively) as did pelvic CT. For both abdominal CT and pelvic CT, fracture detection in all anatomical regions of the pelvic bones was not significantly different for the two reviewers ( P ≥ 0.25). Inter-observer agreement for all anatomical regions of the pelvic bones was excellent or good (k = 0.785–1.0).

Conclusion

Not only pelvic CT but also abdominal CT is acceptable for detection of pelvic fractures, in spite of its thicker sections and different reconstruction algorithm. Therefore, if abdominal CT has already been performed, additional pelvic CT might no longer be necessary in order to exclude a pelvic fracture.
Identification and quantitation of processing parameters controlling the surface quality of carbon fibre-reinforced composites
Authors: Kunze Johannes , Mahrholz Thorsten , Sinapius Michael
Published: January 2016

The paper investigates the effect of essential manufacturing parameters on the surface quality of uncoated carbon fibre-reinforced composites used as car body panels with visible surfaces (Class A properties). A series of carbon fibre-reinforced composites laminates were prepared by the resin transfer moulding technique varying the fibre volume content (30 to 60 %), reinforcement material (woven fabrics vs. unidirectional fibre reinforcements), curing temperatures (40℃ to 120℃), additives (SiO2 nanoparticles as matrix fillers) and using a surface finish applied as an in-mould coating. Laminate surfaces were characterised by roughness analysis (white-light interferometry) and wave-scan measurement to quantify the influence of the different manufacturing parameters on the surface quality. Especially, the used resins were intensively characterised concerning thermal properties and total resin shrinkage. These results correlate very well with the performed analysis of surface roughness. It is found that the fibre print through effect is significantly reduced by realising low total resin shrinkage and an even distribution of resin and fibres at the surface. Thus, using of unidirectional fibre reinforcement (no weft or sewing threads; very fine filaments), low curing temperatures (slow curing processes) and an in-mould coating are most successful for reduction of fibre print through effect and getting surface similar to Class A properties. In addition, the surface quality is quite positively affected by the application of nanoparticles and also strongly controlled by roughness of tooling.
Orthogonal Higher Order Structure of the WISC-IV Spanish Using Hierarchical Exploratory Factor Analytic Procedures
Authors: McGill Ryan J. , Canivez Gary L.
Published: January 2016

As recommended by Carroll, the present study examined the factor structure of the Wechsler Intelligence Scale for Children–Fourth Edition Spanish (WISC-IV Spanish) normative sample using higher order exploratory factor analytic techniques not included in the WISC-IV Spanish Technical Manual. Results indicated that the WISC-IV Spanish subtests were properly aligned with theoretically proposed factors; however, application of the Schmid and Leiman procedure found that the g factor accounted for large portions of total and common variance, whereas the four first-order factors accounted for small portions of total and common variance. Implications for clinical interpretation of the measurement instrument are discussed.
Vitamin D Dosing Strategies Among Jordanians With Hypovitaminosis D
Authors: Khawaja Nahla , Liswi Mohammed , El-Khateeb Mohammed , Hyassat Dana , Bajawi Dalila , Elmohtaseb Mayada , Alkhateeb Hussein , Ajlouni Kamel
Published: January 2016

Objective:

To compare between weekly and daily cholecalciferol in patients with hypovitaminosis D and to determine the optimal maintenance dose.

Methods:

Seventy-one volunteers with hypovitaminosis D were randomly assigned to 2 dose regimens: cholecalciferol 50 000 IU weekly for 8 weeks, then 50 000 IU monthly for 2 months (group A) and 7000 IU daily for 8 weeks, then 12 500 IU weekly for 2 months (group B). Cholecalciferol was stopped for 2 months and reintroduced as 50 000 IU bimonthly for group A and 50 000 IU monthly for group B.

Results:

Two months after therapy, the mean serum 25-hydroxyvitamin D (25(OH)D) level increased from 11.4 to 51.2 ng/mL and from 11.7 to 44.9 ng/mL in groups A and B, respectively ( P = .065). The levels of 25(OH)D declined similarly in both groups during maintenance and after holding therapy. After resuming cholecalciferol, 25(OH)D levels increased to 33.8 and 28.8 ng/mL in groups A and B, respectively ( P = .027). There was a negative correlation between serum 25(OH)D levels and body mass index (BMI; P = .040).

Conclusion:

Timing and frequency of the dosing (daily vs weekly) have no effect on the rise in serum 25(OH)D levels as long as the accumulative dose of cholecalciferol is similar. Cholecalciferol 50 000 IU bimonthly is required to maintain sufficient 25(OH)D levels.
Large deployable network constructed by Altmann linkages
Authors: Song Xiaoke , Guo Hongwei , Li Bing , Liu Rongqiang , Deng Zongquan
Published: January 2016

This study proposes a large-scale modular deployable mechanical network constructed by networking Altmann linkages, which are spatial single-loop mechanisms with six revolute joints and four bars, and develops a theoretical approach to verify the feasibility of the networking method. First, the screw motion equation of the linkage is derived, and the deployability of the linkage is demonstrated through a motion simulation. Second, using the overlapping-unit method, a deployable mechanical network is constructed. The constraint graph of the mechanical network is deduced subsequently. The mobility of the mechanical network is proved by screw theory, which demonstrates the feasibility of the networking method. Then, the motion of the mechanical network is simulated and it is found to have excellent deployability. Finally, a prototype of the mechanical network is fabricated. Results show that spatial single-loop linkages can construct modular deployable mechanical networks with the overlapping-unit method under appropriate connections. This networking method can be verified with the theoretical approach proposed in this work.
Deformation characteristics of discontinuous section of quick-hardening concrete tracks under full-scale test
Authors: Lee Ilwha , Choi Yeong-Tae , Joh Sungho , Um Juhwan
Published: January 2016

A quick-hardening concrete track has been developed to convert old ballast tracks into concrete tracks on operating lines. This method has been utilized to convert urban railways since 1997. With recent increases in train traffic and speed, maintaining track irregularities within design criteria has become essential to ensuring safety. On quick-hardening tracks, track irregularities are predominantly caused by irregular settlement around construction joints. These construction joints are inevitable in quick-hardening concrete; however, they create discontinuous sections that can affect the stable running of trains and structural durability. In this study, full-scale tests were performed with quasi-static and repeated loading on both continuous and discontinuous sections in which the earth pressure acting on the trackbed, accumulated settlement, and elastic displacement were measured. The results obtained indicate that construction joints are disadvantageous in terms of load transfer, settlement, and displacement. Additional field observations conducted on the Seoul Metro Line corroborated the results of the full-scale tests. The overall findings strongly suggest that construction joints on quick-hardening concrete tracks would need to be reinforced.
Fast trajectory tracking of electromagnetic satellite formation with actuator saturation
Authors: Huang Xian-Lin , Zhang Chun , Lu Hong-Qian , Yin Hang
Published: January 2016

Electromagnetic formation flight leverages electromagnetic force to control the relative position of satellites. This new propulsion technique offers a promising alternative to traditional propellant-based spacecraft formation flying since it does not consume fuel. Due to the restriction of maximum current in coils, the available inter-satellite electromagnetic force is small, and its efficient use is an important issue. In this paper, a modified far-field model is proposed to gain better accuracy of electromagnetic force approximation. Based on this model, an adaptive terminal sliding mode control is proposed to achieve fast trajectory tracking. The given method can guarantee the finite-time convergence of tracking error in the presence of bounded disturbance, input uncertainty, and saturation. Numerical simulation results demonstrate the performance and robustness of the proposed control.
What Happened Next
Authors: Campbell Kristine A. , Olson Lenora M. , Keenan Heather T. , Morrow Susan L.
Published: January 2016

Child Protective Services (CPS) identifies over 700,000 victims of child maltreatment in the United States annually. Research shows that risk factors for these children may persist despite CPS intervention. Mothers have unique and often untapped perspectives on the experiences and consequences of CPS intervention that may inform future practice. We explored these perspectives through interviews with 24 mothers after a first-time CPS finding of maltreatment not resulting in out-of-home placement. Male partners were primary perpetrators in 21 cases, with mothers or sitters identified as perpetrators in remaining cases. Data were analyzed using grounded theory. Mothers described risk factors or Roots of maltreatment prior to CPS involvement and reported variable experiences with Recognition of and Response to maltreatment. Divergent Outcomes emerged: I Feel Stronger and We’re No Better. These findings provide an understanding of household experiences around child maltreatment that may support practice and policy changes to improve outcomes for vulnerable children.
Posttraumatic Growth Among Japanese Parentally Bereaved Adolescents: A Web-Based Survey
Authors: Hirooka Kayo , Fukahori Hiroki , Akita Yumi , Ozawa Miwa
Published: January 2016

Objective:

The aim of this study was to explore the factors associated with posttraumatic growth (PTG) among adolescents bereaved owing to parental cancer in Japan.

Methods:

An anonymous cross-sectional Web-based survey was conducted, enrolling adolescents bereaved because of parental cancer in the previous 5 years. Posttraumatic growth, number of social support members, support from medical staff, and behaviors after bereavement were measured. Multiple linear regression was performed to explore the association between total PTG score and possible related factors.

Results:

We assessed 57 participants in this study. Mean age was 19.3 (standard deviation [SD] = 2.0) years, and most participants were female (75.4%). Mean total score of the Japanese version of the PTG inventory was 43.0 (SD = 25.6). Participants’ mean number of social support members was 2.1 (SD = 1.3), and these support members were the surviving parent (66.7%), friends (38.6%), and siblings (36.8%). The multiple linear regression model explained 45% of the variance in PTG. In this model, the following 3 behaviors after bereavement were associated with PTG: “putting palms together in front of a parent’s picture or an altar” (β = .36, P = .006), “visiting a parent’s grave” (β = .29, P = .03), and “having fun with friends” (β = .25, P = .04).

Conclusion:

Parentally bereaved adolescents in Japan experience PTG. Specific behaviors after bereavements might be recommended for PTG among Japanese adolescents bereaved because of parental cancer.
High- versus low-dose leucovorin in the modified FOLFOX6 regimen for first-line treatment of metastatic colorectal cancer
Authors: Reynolds Jana , Chamberland-Tremblay April , Herrington Jon D , Munoz Maldonado Yolanda , Wong Lucas
Published: January 2016

Background

In response to the national leucovorin shortage in 2008, our institution adjusted the modified FOLFOX6 (leucovorin, fluorouracil, and oxaliplatin) protocol to utilize a lower dose of leucovorin (20 mg/m2). This adjustment was based on prospective studies suggesting that lower doses of leucovorin may be equally effective in other fluorouracil containing regimens. This retrospective study evaluates outcomes in metastatic colorectal cancer (mCRC) patients treated with low- (20 mg/m2) vs. high-dose (400 mg/m2) leucovorin in the FOLFOX6 regimen for mCRC.

Methods

This retrospective analysis included consecutive mCRC patients from 2004 to 2011 if they received at least one cycle of modified FOLFOX6 as first line therapy. Patients who received an initial leucovorin dose other than 20 mg/m2 or 400 mg/m2 on their first cycle were excluded. Patient characteristics included demographics, metastatic site at initial diagnosis, and treatment history including chemotherapy and surgery. Primary outcome was date of death or last contact. Cox proportional hazards regression analysis and Kaplan–Meier survival curves were utilized to evaluate the effect of leucovorin dose on overall survival. Log-rank tests were used to compare median survival times by dose group.

Results

Of the 93 mCRC patients who received first line modified FOLFOX6, leucovorin 400 mg/m2 was administered to 47 (51%) patients and 20 mg/m2 to 46 (49%) patients. There were no differences of baseline characteristics between the groups with exception of primary site of cancer ( p = 0.038). The overall survival time was 22.5 months (95% CI 16.6–29.6). The median survival time in the leucovorin 400 mg/m2 group was 23.1 months (95% CI 16.2–35.7) compared to leucovorin 20 mg/m2 which was 20.5 months (95% CI 14.2–34.2); p = 0.573. The median survival times in patients with one versus two or more sites with metastasis were statistically different (26.9 vs. 16.2 months, p = 0.009). Metastatic site removal or ablation showed differences in the median survival, 34.2 months (95% CI 20.8–50.9) vs. 16.6 months (95% CI 14.1–23.6) without metastatic disease removal ( p = 0.004). The odds of dying for patients with two metastatic sites was higher compared with the odds of those patients with one site, HR 1.8 (95% CI 1.08–3.0). Patients without metastatic site removal or ablation had higher odds of dying compared to those patients without this procedure, HR 0.47 (95% CI 0.27–0.81).

Conclusion

In this single center retrospective study, there was no difference in overall survival for mCRC patients treated with first line FOLFOX6 with low- vs. high-dose leucovorin.
Comparison of real-time reverse transcriptase polymerase chain reaction of peripheral blood mononuclear cells, serum and cell-free body cavity effusion for the diagnosis of feline infectious peritonitis
Authors: Doenges Stephanie J , Weber Karin , Dorsch Roswitha , Fux Robert , Hartmann Katrin
Published: January 2016

Objectives

Diagnosis of feline infectious peritonitis (FIP) remains challenging, especially in cats without effusions. The objective of this study was to evaluate the sensitivity and specificity of a real-time reverse transcriptase polymerase chain reaction (RT-PCR) detecting feline coronavirus (FCoV) RNA in peripheral blood mononuclear cells (PBMCs) and serum in comparison with the same real-time RT-PCR in cell-free body cavity effusion.

Methods

This prospective case-control study included 92 cats. Forty-three cats had a definitive diagnosis of FIP, established either by histopathological examination (n = 28) or by positive immunofluorescence staining of FCoV antigen in macrophages of effusions (n = 11), or by both methods (n = 4). Forty-nine control cats had other diseases but similar clinical signs. Real-time RT-PCR was performed on PBMCs of 37 cats (21 cats with FIP, 16 controls), on serum of 51 cats (26 cats with FIP, 25 controls) and on cell-free body cavity effusion of 69 cats (36 cats with FIP, 33 controls). Sensitivity, specificity, positive and negative predictive value, including 95% confidence intervals (CI), were calculated.

Results

Real-time RT-PCR of PBMCs, serum and cell-free body cavity effusion showed a specificity of 100% (95% CI 79.4–100% in PBMCs, 86.3–100% in serum, 89.4–100% in cell-free body cavity effusion) and a sensitivity of 28.6% (95% CI 11.3–52.2%) in PBMCs, 15.4% (95% CI 4.4–34.9%) in serum and 88.9% (95% CI 73.9–96.9%) in cell-free body cavity effusion to diagnose FIP.

Conclusions and relevance

Although it is known that RT-PCR can often provide false-positive results in healthy cats, this real-time RT-PCR was shown to be a specific tool for the diagnosis of FIP when applied in a clinical setting. Sensitivity in cell-free body cavity effusion was high but low in PBMCs and serum. PBMC samples showed a higher sensitivity than serum samples, and are therefore a better choice if no effusion is present.
Numerical analysis of I-Lam honeycomb sandwich panels for collision protection of reinforced concrete beams
Authors: Cheng Shi , Qiao Pizhong , Chen Fangliang
Published: January 2016

Bridge damage due to over-height vehicle collisions is a major issue throughout the transportation network with damages ranging from minor distortion or spalling in fascia girders to almost complete bridge destruction. Repairing such damages resulted from over-height vehicle collisions is expensive, and it includes costs for bridge repair, and rerouting traffic as well as indirect economic and societal costs. In this study, in correlation with a series of impact tests for reinforced concrete beams with or without Impact-Laminate (I-Lam) panel protection by a wooden projectile, the numerical modeling using the finite element codes ABAQUS is conducted to simulate the over-height vehicle impact, and a good agreement with the available experimental data is obtained. Parametric studies are conducted to further investigate the effects of design parameters (e.g. the velocity of projectile, I-Lam parameters, and core layer sequence, etc.) on the effectiveness of the protection system. The observed phenomena from the parametric studies reflect a design philosophy aiming at improving protection efficiency and providing important information on design of I-Lam honeycomb sandwich collision protection systems for field application.
East–west differences and migration in Finland: Association with cardiometabolic risk markers and IMT. The Cardiovascular Risk in Young Finns Study
Authors: Vähämurto Lauri , Pahkala Katja , Magnussen Costan G , Mikkilä Vera , Hutri-Kähönen Nina , Kähönen Mika , Laitinen Tomi , Taittonen Leena , Tossavainen Päivi , Lehtimäki Terho , Jokinen Eero , Telama Risto , Rönnemaa Tapio , Viikari Jorma , Juonala Markus , Raitakari Olli
Published: January 2016

Background: Coronary heart disease mortality has been internationally high in eastern Finland. The excessive mortality risk in Eastern compared with western Finns is explained by differences in cardiometabolic risk profile. Current risk profile differences and association with migration have not been reported. We examined the association of place of residence (east–west) and specifically migration with cardiometabolic risk markers and carotid intima–media thickness (IMT). Methods: The study population included 2204 participants with data available from childhood/youth in 1980 and follow-up examination in 2007. Results: Participants residing in eastern Finland in adulthood had 0.022±0.004mm higher IMT than Western participants. Those who migrated east-to-west had lower IMT than those staying in the east (0.027±0.006mm, p<0.0001) while no difference to those continuously living in the west was found. Those who moved east-to-west had a lower body mass index (25.3±4.3 kg/m2 vs. 26.2±4.5kg/m2, p=0.01), waist circumference (85.7±12.8cm vs. 88.6±12.8cm, p=0.001), prevalence of metabolic syndrome (13% vs. 21%, p=0.01), and higher socioeconomic status (16.6±3.3 vs. 15.0±3.3 school years, p<0.0001) than those who stayed in the east. Conclusions: Higher IMT was found in eastern Finns than in western Finns. Participants who migrated east-to-west had a lower IMT and a better cardiometabolic risk profile than those who stayed in the east.
REVIEW SYMPOSIUM Studying On Study With a reply by Tyson Lewis
Authors: Backer David , D'Hoest Florelle , Ford Derek R , Rocha Samuel D , Lewis Tyson E
Published: January 2016

This article features three engagements with Tyson Lewis's insightful book on studying, with a reply by the author.
Parental Involvement in a School-Based Child Physical Activity and Nutrition Program in Southeastern United States
Authors: Ickes Scott , Mahoney Emily , Roberts Alison , Dolan Carrie
Published: January 2016

Background. Parent involvement varies widely in school-based programs designed to promote physical activity and healthy nutrition, yet the underlying factors that may limit parent’s participation and support of learned behaviors at home are not well understood. Method. We conducted a qualitative study that consisted of one focus group ( n = 5) and 52 in-depth interviews among parents whose children participated in a school-based physical activity and nutrition (PAN) promotion program in Williamsburg, Virginia, United States. We sought to identify factors that enabled or constrained parent’s support of and involvement in children’s programs and to understand the underlying factors that contribute to family success in making dietary and physical activity changes at home. Results. Parents identified their physical and mental health, self-confidence, time, and decision making as underlying “capacities” in the family health pattern. When strengthened, these capacities encourage healthful family behavior and support of school-based PAN programs. Families that succeeded in adopting lessons learned from school-based PAN programs identified four primary strategies for success: shared goals, meal planning, modeling of good behaviors, and collective activities. Conclusions. Interventions that aim to improve child nutrition and physical activity and the broader family health environment should consider underlying capacities of parents and the importance of joint goals and activities.
Leadership in Extreme Contexts
Authors: Geier Michael T.
Published: January 2016

This study sought to investigate whether leaders tend to adapt their leadership style, within the full range of leadership model, between normal and extreme event firefighting contexts; as well as assess the extent these leadership styles are related to followers’ performance across both contexts. The correlational research design was coupled with a cross-sectional retrospective survey using hierarchical regression analysis. Results indicated that transactional contingent reward leadership style was the dominant predictor of followers’ performance in extreme events. Results showed that in normal contexts, transformational leadership style was the dominant predictor of followers’ performance. Leader behaviors tended to change (adapt) between normal contexts and extreme events, as the same leaders were less transformational in their behaviors in extreme events as compared with normal contexts. Theoretical and practical implications for adaptive leadership responses are discussed along with recommendations for future research.
Carotid replacement with Dacron graft in 292 patients
Authors: Koncar Igor , Ribac Jelena Z , Ilic Nikola S , Dragas Marko , Mutavdzic Perica , Tomic Ivan Z , Ristanovic Natasa , Kostic Dusan , Davidovic Lazar
Published: January 2016

Introduction

In case of highly atherosclerotic carotid process, carotid graft replacement might be a potential solution for successful procedure. Many studies evaluated the results of vein and polytetrafluorethilen (PTFE) graft usage at the carotid bifurcation, while the experience on the Dacron graft due to extensive atherosclerotic process is missing. The aim of our study was to evaluate 30-day and long-term results of the Dacron graft on carotid artery used in patients with extensive atherosclerotic disease.

Material and methods

This retrospective study analysed early and long-term neurological outcome as well as Dacron graft patency in patients operated with carotid reconstruction. Early results were confirmed by follow-up clinical examination, whereas late results were assessed by follow-up clinical examination as well as duplex sonographic examination at least 1 year after the surgery. As for statistical methods we used descriptive analysis tests, Chi-square test, and logistic regression.

Results

Carotid graft replacement was performed in 292 patients, before endarterectomy in 155 (53.09%), or after already attempted unsuccessful eversion endarterectomy in 137 (46.91%). Nineteen (6.5%) patients had a stroke due to ipsilateral and contralateral ischaemia or haemorrhagic in 17 (5.8%), 1 (0.3%) and 1 (0.3%) patients, respectively. Significantly higher rate of strokes occurred when the graft reconstruction was used after the failure of endarterectomy (8.5% vs. 3.5%, p = 0.029). Stroke and death rate was 7.19%. Factors that increased risk of early stroke were the length of plaque in the internal carotid artery measured intraoperatively ( p = 0.025) and the surgical tactic to perform graft reconstruction after attempted extensive endarterectomy ( p = 0.029).

Conclusion

Low number of patients with carotid stenosis has extensive atherosclerotic process longer than 4 cm that might jeopardise eversion endarterectomy. Carotid graft replacement with Dacron graft provide early results that are comparable with other conduits; however, in such patients reconstruction should be selected individually based on surgical experience and anatomical distribution of stenotic disease. Due to high risk of stroke, only symptomatic patients with such extensive atherosclerotic disease should be operated.
BRICS summit diplomacy: Constructing national identities through Russian and Chinese media coverage of the fifth BRICS summit in Durban, South Africa
Authors: Grincheva Natalia , Lu Jiayi
Published: January 2016

This study identifies, analyses and compares media content produced by Russian and Chinese TV channels surrounding the events of the fifth BRICS summit in Durban, South Africa, in 2013. The study utilizes a comparative frame analysis to deconstruct and explain media messages communicated by Russian and Chinese media representing national identities of the countries through the BRICS summit diplomacy. The study discusses important questions with regard to the cultural, political and economic contexts that shape the perceptions of the roles and ambitions of Russia and China on the world stage. The major findings clearly demonstrate that Russian and Chinese media adopted different rhetorical frames to portray their national identities through the media coverage of the fifth BRICS summit. These positions imply an interior (in the case of China) or a straightforward (in the case of Russia) approach to communicate a form of ‘collective resistance’ to the global arena, where the countries seek larger global recognition and appreciation.
Acromial and scapular spine fractures after reverse total shoulder arthroplasty
Authors: Mayne Ian P , Bell Simon N , Wright Warwick , Coghlan Jennifer A
Published: January 2016

Acromial and scapular spine fractures after reverse total shoulder arthroplasty occur predominantly as a result of bony insufficiency secondary to patient and intra-operative technical factors. The spectrum of the pathology can range from a stress reaction to an undisplaced or displaced fracture. Prompt diagnosis of these fractures requires a high suspicion in the postoperative patient with a clinical presentation of acute onset of pain along the acromion or scapular spine and/or deterioration of shoulder function. Conventional shoulder radiographs are frequently unreliable in identifying these fractures, especially if they are undisplaced. Computed tomography (CT) and/or single photon emission computed tomography/CT scans are useful imaging modalities for obtaining a definitive diagnosis. Early diagnosis and non-operative treatment of a stress reaction or undisplaced fracture is essential for preventing further displacement and potential disability. The management of displaced fractures is challenging for the orthopaedic surgeon as a result of high rates of mal-union or non-union, decreased functional outcomes, and variable results after open reduction and internal fixation. Strategies for preventing these fractures include optimizing the patient’s bone health, correct glenoid baseplate screw length and position, and avoiding excessive deltoid tension. Further research is required to identify the specific patient and fracture characteristics that will benefit from conservative versus operative management.
Association between diverticulosis and colonic neoplastic lesions in individuals with a positive faecal immunochemical test
Authors: Morini Sergio , Ridola Lorenzo , Hassan Cesare , Lorenzetti Roberto , Boggi Roberto , Napoli Massimo , Tomao Silverio , Zullo Angelo
Published: January 2016

Background

The association between diverticulosis and colonic neoplastic lesions has been suggested, but data in literature are conflicting. This study aimed to investigate such a relationship in patients participating in a colorectal cancer screening program who underwent high‐quality colonoscopy.

Methods

Data from consecutive individuals 50–75 years of age with a positive faecal immunological test were considered. Diverticulosis was categorised as present or absent. The prevalence of neoplastic lesions (adenoma, advanced adenoma, and cancer) between individuals with and those without diverticula was compared. A multivariate analysis was performed.

Results

Overall, data from 970 consecutive individuals were evaluated, and diverticulosis was detected in 354 (36.5%) cases. At least one adenoma was detected in 490 (50.5%) people, at least one advanced adenoma in 264 (27.2%), multiple adenoma in 71 (7.3%), whilst a cancer was diagnosed in 48 (4.9%) cases. At univariate analysis, the adenoma detection rate in patients with diverticula was significantly higher than in controls (55.9% vs 47.4%; p  = 0.011). At multivariate analysis, presence of diverticulosis was an independent risk factor for both adenoma detection rate (OR = 1.58; 95% CI = 1.14–2.18; p  = 0.006) and advanced adenoma (OR = 1.57; 95% CI = 1.10–2.24; p  = 0.013), but not for colorectal cancer.

Conclusions

In a colorectal screening setting, the adenoma detection rate was significantly higher in individuals with diverticulosis than in controls.
Romantic Love in the United States
Authors: de Munck Victor C. , Kronenfeld David B.
Published: January 2016

We seek to advance cultural models theory by contributing to issues related to theory, methods, and testing the external validity of a cultural model. We propose that cultural models are learned as if they were truly properties of collectivities but have no primary existence except in individual representations of them. The shared aspect of cultural models also implies collective awareness of the if–then entailments of cultural models. We use inductive ethnographic methods of freelisting ( n = 80) and pile sorting ( n = 39) to derive a cultural model of romantic love in the United States. From these tasks, we developed a cultural model of successful romantic love consisting of normative scenarios. For successful romantic love relations, a person would feel excited about meeting their beloved; make passionate and intimate love as opposed to only physical love; feel comfortable with the beloved, behaving in a companionable, friendly way with one’s partner; listen to the other’s concerns, offering to help out in various ways if necessary; and, all the while, keeping a mental ledger of the degree to which altruism and passion are mutual. Our model is supported through an examination of two extended case studies. Further research is required, of course, but we believe we have a rather novel and dynamic cultural model that is falsifiable and predictive of successful love relationships. The model is unique in that it combines passion with comfort and friendship as properties of romantic love.
Youth Literacy and Cultural Theories
Authors: Moje Elizabeth Birr
Published: January 2016

Despite decades of research on social contexts and cultural practices, contemporary literacy education policies often frame the teaching of literacy skills—and especially adolescent literacy skills necessary for college and career success—as if they can be understood separate from the purposes, audience, and contexts in which they are made meaningful. Culture, context, and social interaction play roles in understanding young people’s literacy skill development and learning. The field has learned from studies of youth culture that emphasize the role of reading, writing, composing, and communicating with multiple media. Taken together, these varied studies imply how we might better engage young people; help them understand the relevance of learning to read, write, compose, and communicate with proficiency; and prepare them to build their own social futures.
Functional nanostructures of montmorillonite with conducting polyaniline
Authors: Tokarský Jonáš , Peikertová Pavlína , Kulhánková Lenka , Kutláková Kateřina Mamulová , Neuwirthová Lucie , Matějka Vlastimil , Stýskala Vítězslav , Pavla Čapková
Published: January 2016

The present work describes the effect of montmorillonite (MMT) particles on the alignment of conducting polyaniline (PANI) chains in a PANI/MMT composite. The composite was prepared both as a powder, pressed into pellets, and as thin films deposited on glass surfaces. For comparison, pure PANI was also prepared in these two forms. A combination of X-ray powder diffraction analysis and molecular modelling confirmed the successful intercalation of the PANI into theMMT, while Raman spectroscopy confirmed the presence of the conducting form of PANI (i.e. the emeraldine salt) in all samples. Scanning electron microscopy, transmission electron microscopy and atomic force microscopy were used to study the morphologies of all samples. Conductivity measurements showed that the presence of the MMT particles in the PANI/MMT composites contributes to a significant increase in the electrical conductivity in comparison with the pure PANI samples. Moreover, in the pressed pellets the presence of theMMT particles led to an extremely high electrical anisotropy. TheUV-VIS spectroscopy results showed that the PANI/MMT thin film exhibited a selective transmittance in the range 450–650 nm; therefore, the PANI/MMT thin film is not only conductive, but also suitable for use in various optical applications.
High-density bimodal bentonite blends for hydraulic sealings at the Ibbenbüren coalmine
Authors: Wolters Felicitas , Baille Wiebke , Emmerich Katja , Schmidt Eva , Wolters Christian , Königer Franz , Kunz Jürgen , Krase Volker , Schellhorn Matthias
Published: January 2016

The two high-pressure water-retaining dams at the Ibbenbüren coalmine in Münsterland (Germany) have to perform reliably under the induced tension caused by further exploitation of the current mining area. The load-bearing and the sealing functions of the new barriers were separated and new sealing materials were developed. An innovative multilayer sealing system of bentonite and sandwiched equipotential layers (SANDWICH) supporting homogeneous swelling and sealing, independent of formation water (Nüesch et al., 2002), was applied in this project. A testing program of strain-controlled swelling pressure tests on compacted bentonite specimens and on a bentonite/sand mixture was conducted to ensure an adequate potential for swelling-pressure development.

The measurements under constant volume for dry densities between 1.45 g/cm3 and 1.67 g/cm3 showed an evolving swelling pressure between 1.04 and 1.8 MPa for 100% bentonite samples. Straincontrolled oedometer tests for zero strain and step-wise applied strain up to 2% revealed that a sufficient magnitude of swelling pressure existed at maximum applied strain.
Megakaryocyte- and megakaryocyte precursor–related gene therapies
Authors: Wilcox David A.
Published: January 2016

Hematopoietic stem cells (HSCs) can be safely collected from the body, genetically modified, and re-infused into a patient with the goal to express the transgene product for an individual’s lifetime. Hematologic defects that can be corrected with an allogeneic bone marrow transplant can theoretically also be treated with gene replacement therapy. Because some genetic disorders affect distinct cell lineages, researchers are utilizing HSC gene transfer techniques using lineage-specific endogenous gene promoters to confine transgene expression to individual cell types (eg, ITGA2B for inherited platelet defects). HSCs appear to be an ideal target for platelet gene therapy because they can differentiate into megakaryocytes which are capable of forming several thousand anucleate platelets that circulate within blood vessels to establish hemostasis by repairing vascular injury. Platelets play an essential role in other biological processes (immune response, angiogenesis) as well as diseased states (atherosclerosis, cancer, thrombosis). Thus, recent advances in genetic manipulation of megakaryocytes could lead to new and improved therapies for treating a variety of disorders. In summary, genetic manipulation of megakaryocytes has progressed to the point where clinically relevant strategies are being developed for human trials for genetic disorders affecting platelets. Nevertheless, challenges still need to be overcome to perfect this field; therefore, strategies to increase the safety and benefit of megakaryocyte gene therapy will be discussed.
Understanding platelet generation from megakaryocytes: implications for in vitro–derived platelets
Authors: Sim Xiuli , Poncz Mortimer , Gadue Paul , French Deborah L.
Published: January 2016

Platelets are anucleate cytoplasmic discs derived from megakaryocytes that circulate in the blood and have major roles in hemostasis, thrombosis, inflammation, and vascular biology. Platelet transfusions are required to prevent the potentially life-threatening complications of severe thrombocytopenia seen in a variety of medical settings including cancer therapy, trauma, and sepsis. Platelets used in the clinic are currently donor-derived which is associated with concerns over sufficient availability, quality, and complications due to immunologic and/or infectious issues. To overcome our dependence on donor-derived platelets for transfusion, efforts have been made to generate in vitro–based platelets. Work in this area has advanced our understanding of the complex processes that megakaryocytes must undergo to generate platelets both in vivo and in vitro. This knowledge has also defined the challenges that must be overcome to bring in vitro–based platelet manufacturing to a clinical reality. This review will focus on our understanding of committed megakaryocytes and platelet release in vivo and in vitro, and how this knowledge can guide the development of in vitro–derived platelets for clinical application.
Sprouty 2: a novel attenuator of B-cell receptor and MAPK-Erk signaling in CLL
Authors: Shukla Ashima , Rai Karan , Shukla Vipul , Chaturvedi Nagendra K. , Bociek R. Gregory , Pirruccello Samuel J. , Band Hamid , Lu Runqing , Joshi Shantaram S.
Published: January 2016

Key Points

SPRY2 is downregulated in CLL cells from patients with poor prognosis. SPRY2 is negative regulator of Syk-mediated BCR and MAPK-Erk signaling in CLL.
Protein Sequence Annotation Tool (PSAT): a centralized web-based meta-server for high-throughput sequence annotations
Authors: Leung Elo , Huang Amy , Cadag Eithon , Montana Aldrin , Soliman Jan Lorenz , Zhou Carol L. Ecale
Published: January 2016

Background

Here we introduce the Protein Sequence Annotation Tool (PSAT), a web-based, sequence annotation meta-server for performing integrated, high-throughput, genome-wide sequence analyses. Our goals in building PSAT were to (1) create an extensible platform for integration of multiple sequence-based bioinformatics tools, (2) enable functional annotations and enzyme predictions over large input protein fasta data sets, and (3) provide a web interface for convenient execution of the tools.

Results

In this paper, we demonstrate the utility of PSAT by annotating the predicted peptide gene products of Herbaspirillum sp. strain RV1423, importing the results of PSAT into EC2KEGG, and using the resulting functional comparisons to identify a putative catabolic pathway, thereby distinguishing RV1423 from a well annotated Herbaspirillum species. This analysis demonstrates that high-throughput enzyme predictions, provided by PSAT processing, can be used to identify metabolic potential in an otherwise poorly annotated genome.

Conclusions

PSAT is a meta server that combines the results from several sequence-based annotation and function prediction codes, and is available at http://psat.llnl.gov/psat/. PSAT stands apart from other sequence-based genome annotation systems in providing a high-throughput platform for rapid de novo enzyme predictions and sequence annotations over large input protein sequence data sets in FASTA. PSAT is most appropriately applied in annotation of large protein FASTA sets that may or may not be associated with a single genome.
Charcot-Marie-Tooth 2b associated Rab7 mutations cause axon growth and guidance defects during vertebrate sensory neuron development
Authors: Ponomareva Olga Y. , Eliceiri Kevin W. , Halloran Mary C.
Published: January 2016

Background

Charcot-Marie-Tooth2b (CMT2b) is an axonal form of a human neurodegenerative disease that preferentially affects sensory neurons. CMT2b is dominantly inherited and is characterized by unusually early onset, presenting in the second or third decade of life. Five missense mutations in the gene encoding Rab7 GTPase have been identified as causative in human CMT2b disease. Although several studies have modeled CMT2b disease in cultured neurons and in Drosophila, the mechanisms by which defective Rab7 leads to disease remain poorly understood.

Results

We used zebrafish to investigate the effects of CMT2b-associated Rab7 mutations in a vertebrate model. We generated transgenic animals expressing the CMT2b-associated mutant forms of Rab7 in sensory neurons, and show that these Rab7 variants cause neurodevelopmental defects, including defects in sensory axon growth, branching and pathfinding at early developmental stages. We also find reduced axon growth and branching in neurons expressing a constitutively active form of Rab7, suggesting these defects may be caused by Rab7 gain-of-function. Further, we use high-speed, high-resolution imaging of endosome transport in vivo and find that CMT2b-associated Rab7 variants cause reduced vesicle speeds, suggesting altered transport may underlie axon development defects.

Conclusions

Our data provide new insight into how disease-associated alterations in Rab7 protein disrupt cellular function in vertebrate sensory neurons. Moreover, our findings suggest that defects in axon development may be a previously unrecognized component of CMT2b disease.
Annual Hazard Rates of Recurrence for Breast Cancer During 24 Years of Follow-Up: Results From the International Breast Cancer Study Group Trials I to V
Authors: Colleoni Marco , Sun Zhuoxin , Price Karen N. , Karlsson Per , Forbes John F. , Thürlimann Beat , Gianni Lorenzo , Castiglione Monica , Gelber Richard D. , Coates Alan S. , Goldhirsch Aron
Published: January 2016

Purpose

Predicting the pattern of recurrence can aid in the development of targeted surveillance and treatment strategies. We identified patient populations that remain at risk for an event at a median follow-up of 24 years from the diagnosis of operable breast cancer.

Patients and Methods

International Breast Cancer Study Group clinical trials I to V randomly assigned 4,105 patients between 1978 and 1985. Annualized hazards were estimated for breast cancer–free interval (primary end point), disease-free survival, and overall survival.

Results

For the entire group, the annualized hazard of recurrence was highest during the first 5 years (10.4%), with a peak between years 1 and 2 (15.2%). During the first 5 years, patients with estrogen receptor (ER) – positive disease had a lower annualized hazard compared with those with ER-negative disease (9.9% v 11.5%; P = .01). However, beyond 5 years, patients with ER-positive disease had higher hazards (5 to 10 years: 5.4% v 3.3%; 10 to 15 years: 2.9% v 1.3%; 15 to 20 years: 2.8% v 1.2%; and 20 to 25 years: 1.3% v 1.4%; P < .001). Among patients with ER-positive disease, annualized hazards of recurrence remained elevated and fairly stable beyond 10 years, even for those with no axillary involvement (2.0%, 2.1%, and 1.1% for years 10 to 15, 15 to 20, and 20 to 25, respectively) and for those with one to three positive nodes (3.0%, 3.5%, and 1.5%, respectively).

Conclusion

Patients with ER-positive breast cancer maintain a significant recurrence rate during extended follow up. Strategies for follow up and treatments to prevent recurrences may be most efficiently applied and studied in patients with ER-positive disease followed for a long period of time.