bluuebunny/crossref_metadata_2025 huggingface dataset:
Different Lipidomic Signatures between proximal and distal adipose tissue in diabetic nephropathy
Authors: Huang Yuhong , Zheng Xiaodi , Yang Mengxue , Jin Lulu , Zhang Rui , Wu Yueyue , Li Fei , Yang Bo , Liu Jun
Published: March 2024

Perinephric adipose tissue (PRAT) is a component of visceral adipose tissue that is considered an important factor in maintaining renal homeostasis. PRAT has a close relationship with the kidney. Under metabolic dysfunction, PRAT inflammation may precede the damage of blood sugar to the kidney. Whether there is a difference between proximal and distal lipids of PRAT and its significance are not clear. For this reason, we used the nontargeted absolute quantitative method for lipid analysis. The nontargeted analysis method can distinguish various types of lipids in a sample. Absolute quantification of lipids against an internal standard can not only determine the difference in lipid levels between groups but also yield the absolute concentration of lipids in each group. Therefore, we compared the amount and lipid level of PRAT between diabetic kidney disease (DKD) mice and nondiabetic mice and the difference in the lipid spectrum between proximal (within 5 mm from the kidney) and distal (outside 5 mm from the kidney) PRAT in DKD mice. The results showed that DKD mice had significantly more PRAT than the control group. Lipid proteomics found that PRAT in the DKD group significantly differed from that in the control group in glycerides, sphingolipids and phospholipids. Glycerides, including TG (41:10e), TG (43:4), TG (45:7e), TG (52:6) and TG (71:5), were significantly upregulated in PRAT of DKD mice, while TG(56:8e) and TG(55:1) were downregulated. The sphingolipids cer(d36:2), cer(d36:1), cer(d34:2), cer(d34:1) and cerP(t39:3) and the phospholipids PC (38:4), PS (36:4), PS(38:4), PI(42:0), CL(85:1) and CL(76:6) were significantly upregulated in the PRAT of the DKD mice, whereas LPE(16:1e) and PG(41:0) were significantly downregulated. TG(38:3), TG(50:5), TG(52:12e) and TG(56:9e) in the proximal end of PRAT in the DKD group were higher than they were in the distal end, especially TG(38:3), but the sphingolipids and phospholipids in the proximal end of PRAT in the DKD group were downregulated. Our results show that the amount and lipid level of PRAT are significantly higher in DKD mice than non-DKD mice, and there are differences between proximal and distal PRAT. Lipid metabolism in the perirenal fat microenvironment may be related to DKD. These new insights into the mechanism of DKD may be helpful for developing therapeutic strategies for this disease.
Feasibility of Middle Colic Artery as a Landmark for Superior Mesenteric Artery – First Approach in Laparoscopic Pancreatoduodenectomy: a Prospective Study
Authors: NGUYEN Ham Hoi , NGUYEN Thanh Khiem , TRINH Hong Son , DO Hai Dang , LUONG Tuan Hiep , PHAM Hoan My , LE Van Duy , DO Van Minh , CHANTHA Pisey , PHAM Hong Quang , NGUYEN Dang Vung
Published: March 2024

Background
SMA-first approach in pancreatoduodenectomy (PD) has been widely applied in open surgery as well as laparoscopy. Finding the superior mesenteric artery (SMA), inferior pancreatoduodenal artery (IPDA), first jejunal artery (J1A) has become a great challenge in laparoscopic PD (LPD). Meanwhile, exposing the midde colic artery (MCA) might be a feasible approach to determine SMA, IPDA, and J1A. Our study aims to find the anatomical correlation between MCA and SMA, IPDA, J1A, especially in SMA-first approach LPD from the left.
MethodS
Uncontrolled clinical trial with 33 patients undergoing LPD had preoperative contrast abdominal CT scan to analyze the anatomical relevance between MCA and SMA, J1A, IPDA. The operation was performed starting with exposing MCA in advance to find SMA, J1A and IPDA. The data was analyzed by SPSS 25.0.
Results
90.9% of MCA started at 12–3 o’clock from SMA, the mean distance from the SMA root to the MCA and J1A was 56.4mm and 37.4mm, respectively. The distance between SMA and J1A was 19mm. 72.7% J1A started at 9–12 o’clock, 69.7% J1A and IPDA had a common trunk. 78.8% IPDA started at 3–6 o’clock. 100% of the cases had J1A controlled intraoperatively, 81.8% for IPDA when approached from the left, 3% had MCA injury. The mean time to approach from the left was 98 minutes, median blood loss was 100 ml.
Conclusion
Exposing MCA first helps determine SMA, J1A and IPDA safely, efficiently and faciliates SMA-first approach LPD from the left and complete dissection of the mesopancreas and lymph nodes.
Integrated multi-omics network analysis reveals key metabolic pathways in gastric adenocarcinoma
Authors: Xu Botao , Shi Yuying , Yuan Chuang , Wang Cheng , Chai Jie
Published: March 2024

Gastric adenocarcinoma is one of the most death cause cancers worldwide. Metabolomics is an effective approach for investigating the occurrence and progression of tumors and detecting prognostic biomarkers by studying the profiles of small bioactive molecules. To fully decipher the functional roles of the disrupted metabolites that modulate the cellular mechanism of gastric cancer, integrated multi-omics network methods are critical to map the associations between metabolites and genes. In this study, we constructed a knowledge-based multi-omics network of gastric cancer using the dysregulated metabolites and genes between gastric cancer patients and healthy controls. Topological pathway analysis and gene-protein-metabolite-disease association analysis were conducted, and four key gene-metabolite pathways were identified including eleven metabolites associated with modulated genes. The integrated multi-omics network enables mechanistic investigation and provides a comprehensive overview regarding the investigation of molecular mechanisms of gastric cancer, which facilitates the in-depth understanding of metabolic biomarker roles in gastric cancer.
A new probabilistic molecular index
Authors: Palacios José Luis
Published: March 2024

We propose a new molecular index based on a distance on graphs defined through hitting times of random walks on connected graphs. We show the conections to previous probabilistic/electric indices such as the RW inex and the Kirchhoff index, compute its value for some families of graphs, and present some open questions.
Evaluating the low-rank coal biodegradation efficiency bioaugmented with activated sludge
Authors: Kozhakhmetova Marzhan , Akimbekov Nuraly , Tastambek Kuanysh
Published: March 2024

Microbiological treatment of coal is considered an effective and environmentally friendly method. In this work, the effect of microbiological impact on low-rank coal after enrichment with activated sludge was studied. Today, the search for new strategies for separating high-value products from low-quality coal represents a huge niche to explore. In connection with this need, efforts have been made to develop methods for coal solubilization through microbial activities. The microcosm was built with the addition of activated sludge and long-term cultivation. Bacterial communities of coal samples consist predominantly of the phyla Actinobacteria, and Proteobacteria, while Firmicutes and Bacteroidetes were the most abundant phyla for activated sludge. The low-quality coal and biodegradation products were characterized using infrared spectroscopy (FT-IR), and excitation-emission matrix spectrofluorimetry. Using the EEM model, the detected fluorophores were observed at specific wavelength positions at peak E, peak O, peak K, peak E1, peak O1, and peak K1. Peak O, Peak E, and Peak K of the six fluorophores showed the existence of naturally occurring organic materials with humic properties. Based on the FTIR results, it was found that in the bioaugmented microcosm, the transformation of coals was faster than that in the control variant. After incubation, the amount of carboxyl groups in the coals increased, most likely as a result of aerobic oxidation of peripheral non-aromatic structural components of brown coal. The results of CLPP showed that samples of activated sludge have a high metabolic activity of the microbial community when compared to coal. This study shows that the addition of exogenous microflora in the form of activated sludge stimulates the transformation of brown coal.
Analysis of the structural and functional diversity of bacterial microbiota carried by ticks suggests a potential threat of Rickettsia in Liaoning Province, China
Authors: Guo Yaxi , Yu Benliang , Wang Kecai , Yang Guoli , Qiu Huitong , Bai Hua , Liu Xiaogang , Ma Mingxiao , Liu Yuming
Published: March 2024

Objectives
To conduct polymorphism analysis of the tick microbiota in Liaoning Province, explore the tick-borne microbial populations that cause zoonotic diseases.
Methods
In this study, 241 tick specimens were collected from forests and pastures in different areas of the eastern, southern, western, and northern Liaoning Province from May to June, 2023. The four groups of tick specimens were analyzed using microbial 16S amplicon sequencing. The specimens were analyzed for the presence of rickettsiae in their own microbiota environments and subsequently analyzed for the genetic evolution of their 16S, ompA, and ompB genes. Rickettsiae were successfully isolated by infecting a baby hamster kidney (BHK) cell line and staining with Swiss-Giemsa composite stain.
Results
Sequencing of the LNW, LNE, LNN, and LNS 16S amplicons yielded 140,027, 132,756, 133,476, and 133,331 sequences, respectively. Diversity analysis showed that the LNN group higher microbial community richness, and more uniform species distribution. A total of 1,671 amplicon sequence variants (ASVs) were identified through sequence comparison and species annotation. Among these sequences, 92.46% of ASVs could be annotated to the database, with genus being the most abundant in all four groups of samples, followed by species. The homology of the Rickettsia 16S, ompA, and ompB genes obtained from the LNW and LNS groups was 99.3%, 93.9%, and 96.2%, respectively. The successfully isolated and purified rickettsiae-infected BHK cells could cause cellular lesions.
Conclusion
Ticks of multiple genera in Liaoning Province carry a rich bacterial microbiota. The severe infection of Rickettsia poses a potential threat to both humans and animals.
The Correlation of Weight Self-Stigma and Social Appearance Anxiety in People With Obesity
Authors: KAVAK Mustafa , ERKAN Fatma Melike , GÜLTEKİN Abdurrezzak , ARSLAN Mustafa , BUDAK Funda KAVAK
Published: March 2024

Background: Obese individuals are exposed to stigma and social appearance anxiety. Internalized weight stigma negatively affects mood, self-esteem, body image in obese individuals.
Aims: The aim of this study is to determine the correlation of weight self-stigma and social appearance anxiety in people with obesity.
Methods: The sample size of the study, which was conducted as a relational descriptor, consisted of 224 patients. "Descriptive Characteristics Form", "Internalized Weight Bias Scale" and " Social Appearance Anxiety Scale " were used as data collection tools in the research.
Results: It was determined that there was a statistically strong positive correlation between internalized weight stigma and social appearance anxiety of obese individuals participating in the study (p<0.05). In addition, it was determined that internalized weight stigma had statistical significance in explaining social appearance anxiety in obese individuals and predicted it at a rate of 67% (p<0.05).
Conclusions: Considering the scale total score average in the study, it was found that the internalized weight stigma/bias and social appearance anxiety of obese individuals were high.
Comparative Analysis of Automatic Literature Review Using Mistral Large Language Model and Human Reviewers
Authors: Tsai Hsiao-Ching , Huang Yueh-Fen , Kuo Chih-Wei
Published: March 2024

This study evaluates the effectiveness of the Mistral Large Language Model (LLM), enhanced with Retrieval-Augmented Generation (RAG), in automating the process of conducting literature reviews, comparing its performance with traditional human-led review processes. Through a methodical analysis of 50 scientific papers from the OpenReview platform, the study investigates the model's efficiency, scalability, and quality of review, including coherence, relevance, and analytical depth. The findings indicate that while the Mistral LLM significantly surpasses human efforts in terms of efficiency and scalability, it occasionally lacks the analytical depth and attention to detail that characterize human reviews. Despite these limitations, the model demonstrates considerable potential in standardizing preliminary literature reviews, suggesting a hybrid approach where Mistral LLM's capabilities are integrated with human expertise to enhance the literature review process. The study underscores the necessity for further advancements in AI technology to achieve deeper analytical insights and highlights the importance of addressing ethical concerns and biases in AI-assisted research. The integration of LLMs like Mistral presents a promising avenue for redefining academic research methodologies, pointing towards a future where AI and human intelligence collaborate to advance scholarly discourse.
Understanding Echoics: Identifying the Predictive Indicators of Imitative Vocal Speech
Authors: Mason Lee , Bolds Alexis , Gavagan Maeve , Ninness Chris
Published: March 2024

Purpose: Across the heterogeneous population of individuals diagnosed with autism spectrum disorder, a growing body of literature supports the use of echoic prompts toward conditioning other functional language skills. Identifying the prerequisite skills of an echoic repertoire may be beneficial for treatment planning and clinical decision making.
Methods: A chart review was conducted for 118 patients with autism who received early intensive behavioral intervention to address the core deficits of their diagnosis. We examined the Level 1 scores on the Verbal Behavior Milestones Assessment and Placement Program (Sundberg, 2014) for all patients. Using their scores on the echoic skills subtest as a dependent variable, we ran a binomial logistic regression in which the remaining eight domains, along with age and sex, served as independent variables.
Results: Our logistic regression model was statistically significant: X2(10) = 109.61, p < .001. The model explained 86.0% of the variance in echoic verbal behavior, and correctly classified 95.8% of cases. Patients who demonstrated a mand repertoire were greater than 3.5 times more likely to also exhibit an echoic repertoire. Additionally, vocal play and motor imitation were associated with an increased ability to echo.
Conclusion: Using binomial logistic regression, we identified three predictors influencing the echoic verbal behavior for children with autism. Patients who demonstrated these three skills were statistically significantly more likely to echo the vocal verbal behavior of others. Additional research is now needed to confirm a functional relationship between each of these predictors and echoic behavior
Mining novel biomarkers for prognosis of skin cutaneous melanoma with proteomic analysis
Authors: Zhang Fan , Li Yongchuan , Mao Jianyu , Fu Qiang
Published: March 2024

Melanoma, a highly malignant tumor arising from melanocytes, poses a significant health threat with increasing incidence. This study leveraged proteomics, analyzing 352 samples from the Cancer Genome Atlas. We identified eight prognosis-related proteins (FOXO3A, CD171, CASPASE7CLEAVEDD198, Melanoma gp100, SRC, 1433ZETA, P21, and CABL) and constructed a prognostic model. The model accurately predicted patient outcomes, distinguishing high- and low-risk groups. Statistical analysis revealed no significant differences in clinical phenotypes between these groups. Principal Component Analysis validated model efficacy, and survival analysis indicated lower overall and progression-free survival in high-risk patients. Independent prognostic analysis and ROC curve analysis affirmed the model's reliability, with a higher predictive capacity than traditional clinical traits. Correlation analysis linked prognosis-related proteins with age, gender, and tumor stage. Our findings contribute valuable insights for diagnostic markers, drug targets, and understanding SKCM pathogenesis, advancing precision medicine. Limitations include the need for subgroup analysis and additional in vitro/in vivo validation.
Sensory Phenomenon Assessment Scale (SPAS): a New Tool for Assessment of Tic-associated Sensations
Authors: Wang Xianbin , Li Yanlin , Yu Liping , Xu Hui , Zhang Anyi , Zhang Wenyan , Jiang Zhongliang , Cui Yonghua , Li Ying
Published: March 2024

Background Sensory symptoms linked to tic disorder (TD) are challenging to quantify via self-or parent-reported measures. The current study aimed to develop a novel observer-rated semi-structured interview, namely the Sensory Phenomenon Assessment Scale (SPAS), to aid clinical evaluation on symptoms of tic disorder among children.Methods To test its psychometric properties, tic, premonitory urge (PU) and obsessive-compulsive symptoms (OCS) were also assessed in 223 children via the Yale Global Tic Severity Scale (YGTSS), Premonitory Urge for Tic Scale (PUTS) and the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS). Factor analysis and internal consistency test were carried out using data from TD-diagnosed individuals.Results Good internal consistency and test-retest reliability were observed. Criterion validity was established by significant correlations between the PUTS, the YGTSS, the CY-BOCS, and scores of the SPAS. Factor analyses supported a single-factor model of the SPAS, in which the 5 items each showed a factor loading above 0.6.Conclusion This study demonstrated that the SPAS is reliable and valid, thus can serve as a good and concise measure of clinical symptoms among children and adolescents with tic disorder.
Robust MPC for helicopter TRMS (2D of helicopter)
Authors: Khali Sonia , Zehri Oussama
Published: March 2024

Is a well- created control strategy for optimum control of strained multivariate systems. The twin-rotor multiple-inputs multiple-outputs (TRMS) is a non-linear system with important cross-coupling between horizontal and vertical axes presenting great challenges in the conception of modeling and control. There are cases once a theoretical conception can create issues once it involves to practical implementation, especially when conception is for non-linear systems. That’s why this paper presents a notably feasible MPC conception for TRMS that has been performed with success on a laboratory TRMS benchmark. The given conception is better adapted for TRMS as a result of that it will handle the control constraints related with the system through to the optimization algorithm program underlying the MPC scheme. From the point of vision of the system, all control objectives are addressed, viz. stabilizing the system in coupled conditions and ensure that its beam can follow a specified reference path or reach the desired positions in 2DOF (two degrees of freedom) without violating control input constraints. The conception also incorporates the disturbance rejection requirement. Simulation and experimental results are presented to show that the results of the practical performance are consistent with the simulated results.
Nest box-mounted PIT tag readers reveal cryptic recruits of cavity-nesting waterfowl in south Louisiana
Authors: Miranda Katie E. , Ringelman Kevin M. , Bakner Dylan L.
Published: March 2024

Black-bellied Whistling-Ducks (Dendrocygna autumnalis; hereafter, BBWD), are rapidly expanding northward into the core range of the eastern Wood Duck (Aix sponsa; hereafter WODU), yet little is known about their nesting ecology. Typical field methods to study cavity-nesting waterfowl (i.e., weekly nest monitoring) preclude a full understanding of important breeding information, including nest prospecting and parasitic egg laying. To address this, we used subcutaneous passive integrated transponder (PIT) tags embedded in adults and PIT tag readers mounted on nest boxes with the objective to (1) identify individuals that used nest boxes but were not physically captured on a nest, (2) quantify box visitation, and (3) quantify BBWD pair and WODU hen behaviors during the prospecting, laying, and incubation periods. We deployed RFID readers on 40 duplex-style nest boxes from March–December 2022 in Louisiana with the potential to detect BBWD and WODU marked with PIT tags in 2020–2022. We detected 48 (BBWD n = 26, WODU n = 22) adults of both species via RFID readers, and 33% (n = 16) of individuals (50% of BBWD, n = 12; 14% of WODU, n = 3) were never otherwise recaptured in 2022, meaning that traditional field methods for cavity-nesting waterfowl would fail to document a substantial number of birds potentially contributing to the population via parasitism. We also determined that BBWD preferentially visited (and subsequently nested in) boxes that are >1 year old (β = 1.32, CI = 0.97, 1.66), while WODU did not display a preference. Due to the generalist nature and rapid expansion of BBWD, an apparent neophobia of newly installed boxes was unexpected, especially since there were several successful WODU nests in the new boxes before BBWD began nesting in 2022. Our study is one of the first to evaluate BBWD nesting behaviors within the core WODU breeding range, and the first to used nest box-mounted PIT tag readers to observe BBWD behavior.
Low Temperature Tolerance of Peach Flower Buds and Shoot Tissues Is Differentially Influenced by Freezing and High Temperature Exposure
Authors: Moran Renae E. , Ginakes Peyton
Published: March 2024

In northern temperate zones, peach trees are vulnerable to cold temperature injury in the fall, particularly as climate change prolongs warm weather in the fall and potentially delays the onset of cold acclimation. Four experiments evaluated how cold acclimation of flower buds and shoot phloem, cambium, and xylem is affected by exposure to varying temperatures in the fall. One-year-old peach shoots from trees grown in Maine, USA, were collected from October through November, exposed to 1, 3, or 6 days of low, high, and freezing temperatures, and subjected to stepwise controlled freezing to about −30 °C. Injury was visually quantified as oxidative browning of flower buds and shoot tissues. High temperature exposure, even of a single day, decreased cold tolerance of flower buds and shoot tissues until late November, when high temperatures only minimally decreased cold hardiness. In mid-November, increasing the duration of high temperature exposure from 1 to 3 days decreased cambium and phloem hardiness, but hardiness in flower buds was not further decreased by the longer duration of 3 days. By late November, hardiness in flower buds, cambium, and phloem was less responsive to high temperature, and was increased by prior exposure to 6 days of freezing. After high temperature, xylem lost hardiness to a small degree in mid-October and late November, but in mid-November this occurred in only one experiment. In this study, deacclimation during high temperature in the fall was greater in cambium and phloem than in flower buds and at times greater than in xylem.
An exact method for bosonizing the Fermi surface in arbitrary dimensions
Authors: Park Takamori , Balents Leon
Published: March 2024

Inspired by the recent work by Delacretaz et. al. [Phys. Rev. Res. 4, 033131 (2022)], we rigorously derive an exact and simple method to bosonize a non-interacting fermionic system with a Fermi surface starting from a microscopic Hamiltonian. In the long-wavelength limit, we show that the derived bosonized action is exactly equivalent to the action obtained by Delacretaz et. al. In addition, we propose diagrammatic rules to evaluate correlation functions using our bosonized theory and demonstrate these rules by calculating the three- and four-point density correlation functions. We also consider a general density-density interaction and show that the simplest approximation in our bosonic theory is identical to RPA results.
Vaccination against human papillomavirus in aggressive juvenile respiratory papillomatosis
Authors: Korovkina E. S. , Kostinov M. P.
Published: March 2024

In recent years there has been an increase in cases of papillomatosis of the upper respiratory tract, including in childhood, which is a significant problem. More than 70 % of children have severe recurrent forms of the disease. It has been proven that the development of respiratory papillomatosis is associated with infection with human papillomavirus, more often HPV types 6 and 11. The development of respiratory papillomatosis in childhood may be a consequence of infection with the human papillomavirus of the respiratory tract at the time of birth, and HPV reactivation may occur after injury or infection. The treatment of this condition is a significant problem, since during surgical treatment, only the visible pathological process is excised, and no effect on the etiological factor is produced. Therefore, the most optimal can be considered to be vaccination against HPV with available vaccines at the stage of pregnancy planning in previously unvaccinated individuals, as well as vaccination against HPV in already infected individuals with existing respiratory papillomatosis. In our article, we present a case of successful vaccination of a 2-year-old child with an aggressive course of respiratory papillomatosis against HPV.
Comparative assessment of intestinal microbiota in autoimmune and non-autoimmune liver diseases in children
Authors: Nikitin A. V. , Volynets G. V. , Potapov A. S. , Dudurich V. V. , Danilov L. G.
Published: March 2024

The influence of the gut microbiota on the development of various diseases is of great interest to researchers. The conducted studies showed that in patients with chronic liver diseases, the dominant taxa of the gut microbiota were Bifidobacterium longum, Bifidobacterium adolescentis, Blautia massiliensis, and in healthy children — Neisseria flavescens. There is no comparative analysis of data on the taxonomic diversity of the intestinal microbiota in autoimmune and non-autoimmune liver diseases in children.

   Purpose. To investigate differences in the taxonomic diversity of fecal microbiota in patients with autoimmune and non-autoimmune liver diseases, as well as to evaluate potential biomarkers of 16S rRNA gene amplicons in these diseases by comparing the taxonomic composition.

   Material and methods. A metagenomic analysis of the intestinal microbiota of 24 children with chronic liver diseases (mean age 10,3 ± 4,7 years) was carried out with the isolation of the 16S rRNA gene region. The group included 18 children with autoimmune liver diseases and 6 children with non-autoimmune liver diseases.

   Results. The conducted study revealed 684 types of microorganisms in the studied samples of patients’ feces. The analysis of the conducted studies showed that no dominant taxa were found in the fecal samples of children with autoimmune liver diseases, while Veillonella dispar, Veillonella parvula, Cloacibacillus porcorum, Prevotella histicola and Bacteroides eggerthii were the dominant taxa in patients with non-autoimmune liver diseases.

   Conclusion. Studies have shown differences in the composition of the gut microbiota in children with autoimmune and non-autoimmune liver diseases.
Tourism and hospitality industry: A case study of Polish female firms
Authors: M. Zapalska Alina , McCutcheon Robin
Published: March 2024

The objective was to identify the firms’ short-run and long-run strategies that contributed to firms’ development, job creation and economic growth of local economies, and employees’ and customers’ satisfaction across all Butler’s stages of development. The results indicate that the firms have been successful supporting environmental sustainability, conservation of natural resources, and protection of cultural elements of local communities. During the Covid-19 shutdown, the female entrepreneurs assessed past strategies, invested in development and production of new and better-quality products and services, advanced employees’ and entrepreneurial skills, and transformation of digital and production infrastructure. The study identified the importance of government policies critical for entrepreneurship success, particularly during global crises. The paper illustrates several lessons focused specifically on fostering a supportive work environment that enables firms to endure through and successfully recover from market shocks or global crises. The study concludes that all female entrepreneurs were experienced, motivated, visionary, goal-oriented, and innovative regarding their entrepreneurial undertakings while focusing on understanding the needs and maximizing employee and customer satisfaction. The resiliency they developed enabled them to stay focused on their goals and maintain successful operations while facing insufficient financial and non-financial support, market challenges, and global crises.
Violência escolar: Arquivando traumas e enfrentando desafios na filosofia da educação, psicanálise e educação
Authors: Trevisan Amarildo Luiz , Silva Alexandre Oliveira , Luft Bibiana Silveira
Published: March 2024

O texto pretende compreender, na perspectiva da relação filosofia da educação, psicanálise e educação, a viabilidade da institucionalização de práticas dialógicas informadas como contraponto e prevenção à violência na educação. Para isso, trata das dificuldades de seus registros em arquivos e o imperativo de (re)construir mediações dialogadas e propositivas, com vistas a sua melhor compreensão e enfrentamento na convivência da relação educando e educador. O objetivo é investigar hermeneuticamente as contribuições de Freud, Adorno e Derrida sobre a relação entre violência, linguagem e memória. Além disso, pretende auscultar os professores e gestores de escolas públicas de cinco (5) municípios gaúchos, através da análise de uma experiência de ensino e pesquisa realizada através do curso de Ciências da Religião – UAB/UFSM. O intuito é compreender de forma edificante o lugar vago da docência de forma dialogada e esclarecida, pretendendo (re)construir mediações teóricas e estratégias de intervenção como forma de enfrentamento à violência na/da educação. Nesse sentido, levanta subsídios na reflexão dialógica da prática pedagógica de educadores das redes de ensino, no sentido de problematizar o significado da relação teoria e prática na formação de professores, em tempos de exceção normalizadora e da ausência de arquivos contendo informações específicas de cada escola.
Aquisição da categoria dos determinantes em português por surdos
Authors: De Oliveira Adriana Stella Cardoso Lessa , Lopes Lucília Santos da França
Published: March 2024

Este estudo trata da aquisição, por surdos adultos, da categoria funcional de determinantes (DP- Determiner Phrase) em português brasileiro escrito (PB). A partir de coleta de dados naturalísticos, produzidos por seis sujeitos-informantes surdos adultos, fluentes em Libras, explanamos sobre aspectos internos e fatores externos que caracterizam a aquisição de determinantes definidos na escrita de surdos adultos com nível superior. Com base no quadro teórico gerativista, investigamos os traços formais que caracterizam parametricamente a categoria dos determinantes (D) nas línguas nativa (Libras) e alvo (Português escrito), comparando os traços de D nessas línguas com o que foi encontrado nos dados de interlíngua produzidos pelos sujeitos-informantes. Quanto aos fatores externos, procuramos identificar algum tipo de interferência na aquisição do português escrito por nossos informantes, em relação: à idade de aquisição da Libras e/ou do PB; à inserção em família surda ou ouvinte, ser falante ou não falante de Libras; e ao grau de escolaridade. Como resultado, verificamos que a categoria dos determinantes em PB se apresenta em estágios variados de interlíngua nos dados dos sujeitos-informantes e que a aquisição dessa categoria se dá traço a traço, a partir de seus traços formantes, entre os quais estão definitude, gênero, número, dêixis e anáfora
LIPASE FROM Rhizopus oryzae IMMOBILIZED ON CORN COB POWDER: A NEW APPROACH FOR DIETETIC TRIGLYCERIDE SYNTHESIS IN A FIXED BED REACTOR
Authors: Pacheco Bruna , Andrade Grazielle , de Paula Ariela
Published: March 2024

This work explores the possibility of using corn cob powder as a carrier for immobilization by physical adsorption of lipase from Rhizopus oryzae used in acidolysis reaction of grape seed oil with capric acid (C10) to synthesize dietary triglycerides (TAGs) formed from medium-long-medium chain (MLM) fatty acids in a fixed bed reactor. First, enzymatic loading was investigated to improve hydrolytic activity and the immobilized biocatalyst was characterized in terms of biochemical parameters and thermal stability. An enzyme load of 30 mg mL-1 was quite adequate, as about 90% of the immobilization yield was achieved. The central composite rotatable design (CCRD) experimental design revealed that, for the immobilized enzyme, the optimal hydrolytic activity was obtained at pH 7.75 and 41 °C. Stirred tank reactions were optimized in CCRD statistical analysis revealing the most desirable conditions for molar ratio of 1:9.36 (oil:acid), 45 °C and 15% biocatalyst, obtaining a maximum ID value of 86.93 ± 2.25%. In a fixed bed reactor, the synthesis showed an average ID of 51.13 ± 0.77, demonstrating the potential of this configuration. It is concluded that corn cob powder as an immobilization carrier is a promising alternative for the enzymatic synthesis of MLM triacylglycerols.
Green synthesis of Fe-nanoparticles using pruned tea leaf extract: characterization and use for degradation of dyes from aqueous phase in Fenton-like systems
Authors: Liu Xiyao , Zhao Wenchang , Huang Zechun , Ko Tzu-Hsing , Song Zhijian , Han Hau , Yilmaz Murat
Published: March 2024

Green synthesis of nanoparticles (NPs) is considered a highly promising technology for materials. The use of plant-based NPs is the simplest with high reproducibility. Iron nanoparticles (Fe-NPs) were synthesized by pruned tea leaf extract and FeSO4 and were analyzed by XRD, FTIR, XPS, and TEM. The catalytic activity of the Fe-NPs was evaluated for dye degradation under different operating parameters. Kinetc and thermodynamic tests were also conducted to study the reaction behavior. Results showed that the Fe-NPs had an average pore size of 17.9 nm with a surface area of 2.54 m2 g−1. The Fe-NPs contained Fe–O bonds and bioactive substances. The crystalline Fe-NPs were composed of FeOOH, Fe2O3, and α-Fe forms. XPS showed the presence of Fe3+ and Fe2+ in a ratio of 1.78, with Fe2+ accounting for over 64%. TEM revealed the spherical structure with particle size around 34–52 nm. The degradation efficiency of Congo red (CR) surpassed 95% within 30 min for the Fenton-like system, while sole adsorption only achieved 50%. Increasing the solution pH had a significant negative effect. Pseudo-second-order model provided the best fit. Thermodynamic calculations revealed that the catalytic degradation is favorable, spontaneous, and endothermic. Reusability demonstrated that over 95% retention was achieved after five cycles.
¿Es Platón un atomista? consideraciones acerca de los cuerpos primarios y su constitución
Authors: Rodríguez Herrera Julián David
Published: March 2024

El texto presenta un análisis del diálogo platónico Timeo con respecto a la composición de la materia que constituye el mundo generado. El objetivo es responder a la pregunta de si Platón es un atomista y, si lo es, en qué sentido. Para esto se analizan tres propuestas: el atomismo de Demócrito, el atomismo de superficies, y el atomismo matemático, basado en la propuesta antiatomista de Brisson y Ofman, más el análisis desde la química de Di Giacomo. El estudio se centra en la conformación de la materia y en la composición del Universo. Se plantean dos principios que deberían tener las propuestas atomistas: la teoría de la constitución del universo que está basada en cuerpos mínimos que forman la totalidad del mundo y son intercambiables entre ellas y, simplifica la composición del Universo. Se concluye que Platón no es un atomista en el sentido estricto de la palabra, pero su teoría comparte algunas similitudes con el atomismo; como la idea de que la materia está compuesta por partículas mínimas y la importancia de la proporción en la conformación del Universo.
SUAP: uma reflexão sobre acessibilidade digital para surdos e deficientes visuais
Authors: Diniz Fernandes Pimenta Graziele , Barbosa da Silva Aldeni
Published: March 2024

Este trabalho teve o objetivo de buscar e apresentar as faltas de acessibilidade digital encontradas no Sistema Unificado de Administração Pública (SUAP) e mostrar possíveis soluções para melhorar a utilização do site para alunos surdos e com deficiência visual do IFPB. Constituiu-se de uma pesquisa de cunho qualitativo e descritivo, a partir de entrevista e aplicação de questionário com alunos com deficiência visual e surdos do IFPB. O questionário foi aplicado no campus Campina Grande com 11 alunos, sendo 9 deles surdos e 2 deficientes visuais. Com base nas respostas foram construídos gráficos que mostraram algumas dificuldades enfrentadas ao acessar o SUAP. De acordo com os resultados obtidos com a aplicação do questionário, observou-se que 100% dos entrevistados sentem dificuldades de acessar o SUAP. Com relação ao grau de acessibilidade para deficientes visuais e surdos, 100% dos entrevistados afirmaram que o SUAP possui pouca acessibilidade virtual. Com relação a frequência de utilização do SUAP, 63,6% dos entrevistados afirmaram que utilizam regularmente, 27,3% utilizam com pouca frequência e 9,1% utilizam com muita frequência. Para ocorrer as mudanças necessárias e tornar o site acessível, foram apresentados alguns softwares que podem promover essa acessibilidade de forma eficiente e qualificada para surdos e deficientes visuais. Com isso, as informações levantadas na pesquisa se fizeram importantes, permitindo verificar que o mercado se preocupa em criar softwares que facilita a comunicação de pessoas deficientes visuais e surdos ao ambiente virtual podendo torná-las mais produtivas e incluídas na sociedade podendo estes serem caminhos para tornar o SUAP mais acessível.
Inovação pedagógica e gestão democrática: reflexões a partir de uma escola pública de educação básica
Authors: Kotzias Baptista Barroso Cecilia , Monteiro Will Daniela Erani
Published: March 2024

Em tempos de recusa às concepções pedagógicas tidas como tradicionais e ao forte apelo à inclusão das novas tecnologias de informação e comunicação nas escolas, a inovação pedagógica apresenta-se como elemento que fomenta a mudança de atitude dos profissionais da educação quanto às formas de gestão e de desenvolvimento do currículo, sustentada por políticas públicas e condições objetivas de trabalho. Com o objetivo de refletir sobre as possibilidades e limites da inovação na educação escolar, desenvolvemos um estudo de caso em uma escola pública municipal de Florianópolis, considerada inovadora, pela Secretaria Municipal de Educação. Realizamos entrevistas, observações, análise documental e dialogamos com algumas das práticas pedagógicas e de gestão. Foi possível identificar que, apesar dos limites, a gestão democrática praticada na instituição apresenta-se como uma ferramenta essencial na construção das iniciativas inovadoras.
Avaliações de desempenho na esfera pública: o caso de um hospital municipal
Authors: Araujo Monteiro Luciano
Published: March 2024

O presente estudo visa a analisar a eficiência das avaliações de desempenho que são utilizadas na instituição onde atuo, um hospital municipal, e refletir sobre alternativas para torná-las mais confiáveis. Para tanto, é utilizada bibliografia específica, presente em artigos científicos e fontes bibliográficas, assim como de dados estatísticos governamentais. Foram evidenciados os motivos que tornam inadequados os modelos de avaliação vigentes, dentre os quais o constrangimento sofrido por subordinados em relação à sua chefia imediata (pois se trata de pesquisas nominais) e a falta de órgãos isentos para tomada de decisão. Sendo assim, torna-se imperativo que tais pesquisas sejam alvo de estudo por uma empresa privada e idônea, a fim de que seja assegurada a confidencialidade dos dados obtidos e que, de fato, elas possam servir como indicador para revelar os problemas institucionais.
Marco Raúl Mejía: pesquisa e prática em educação popular
Authors: Lima Higo , Feitosa Queiroga Ney Arthur
Published: March 2024

O colombiano Marco Raúl Mejía é um dos principais nomes da educação popular na américa latina, acumulando publicações dedicadas aos estudos acadêmicos e à vivência organizativa em comunidades periféricas. Neste interim, o professor Mejía se filia à compreensão de “Sul” enquanto um lugar epistêmico, não meramente territorial, a partir do que compreende como sendo o quarto paradigma educacional. O educador Paulo Freire é uma de suas principais bases conceituais, desde o primeiro contato com a metodologia, ainda na fase escolar. Em 2015, Marco Raul Mejía visitou a cidade de Angicos/RN e conheceu os estudantes que vivenciaram a experiência pioneira de alfabetização pelo método das 40 Horas, em 1963. Nesta entrevista, ele destaca o valor testemunhal dos “mitos originários”; resgata sua trajetória na Educação Popular; os desafios de um novo paradigma na educação latino-americana; e ainda critica os segmentos organizados que militam contra o legado de Paulo Freire.
A ordem do comum: uma visão de Muniz Sodré sobre o campo da comunicação
Authors: Filipini Mendes Isabella
Published: March 2024

Apresenta a resenha da obra “A ciência do comum: notas para o método comunicacional”, de Muniz Sodré. Aborda temas de interfaces compartilhadas com a comunicação. A discussão teórica em torno do campo da comunicação busca determinar limites epistemológicos para delimitar métodos, zonas de abrangência e objetos de estudos genuínos de uma ciência comunicacional.
Daptomycin Inhibits Multiple Myeloma Progression through Downregulating the Expression of RPS19
Authors: Zhuang Yijun , Zhang Yin , Chen Caiyun , Chen Jincheng , Xu Qiuxia , Wang Peihong
Published: March 2024

Objectives:

This study aimed to explore new therapeutic drugs for multiple myeloma
(MM). MM is a common plasma cell malignant proliferative disease, accounting for 15% of
hematological malignancies. The role of daptomycin (DAP), a potential anti-tumor drug, remains
unclear in MM. In the present research, we investigated the anticancer effect of DAP in
MM cell line RPMI 8226.

Methods:

RPMI 8226 cells were treated with DAP (20 μM, 40 μM, and 80 μM) with 20 nM
bortezomib (BZ) as a positive control. Cell function was detected using CCK8, flow cytometry,
and transwell assay.

Results:

In MM cells, DAP inhibited proliferation and induced apoptosis. The cell cycle was arrested
at the G1 phase after the treatment of DAP. The migration and invasion abilities were also
inhibited by DAP treatment in RPMI 8226 cells. Importantly, the mRNA and protein levels of
RPS19 were downregulated in DAP-treated RPMI 8226 cells.

Conclusion:

DAP inhibited the proliferation, migration, and invasion and promoted the apoptosis
of MM cells. Mechanistically, the RPS19 expression was significantly decreased in DAPtreated
cells. This research provides a potential therapeutic drug for MM therapy.
The Diagnostic Value of Abnormal Bone Marrow Signal Changes on Magnetic
Resonance Imaging: Is Bone Marrow Biopsy Essential?
Authors: Arikan Fatma , Yildiz Yasin , Ergelen Rabia , Atagündüz Isık , Toptas Tayfur
Published: March 2024

Background::

It is essential to determine whether bone marrow signal changes on magnetic resonance imaging (MRI) represent a physiological response or
pathology; at present, the clinical significance of these signal changes is unclear. It is unknown whether a bone marrow biopsy is required when
bone marrow signal changes are detected incidentally in individuals without suspected malignancy.

Objective::

The primary purpose of this study was to determine whether incidentally detected bone marrow signal changes on MRI performed for various
reasons (at the time of admission or during follow-up) are clinically significant.

Methods::

We retrospectively evaluated the bone marrow biopsy clinical and laboratory findings of 42 patients with incidental bone marrow signal changes
on MRI between September 2016 and January 2020. We also determined whether the patients were diagnosed with malignancy during admission
or follow-up.

Results::

Of the 42 patients, three (7%) were diagnosed with hematological malignancies during admission, while two were diagnosed with multiple
myeloma and one with B-cell acute lymphoblastic leukemia. Of the 42 patients, 35 had a mean follow-up of 40.6 ± 5.3 months. One patient was
diagnosed with monoclonal gammopathy of undetermined significance four months after their first admission.

Conclusions::

In addition to MRI, detailed clinical and laboratory evaluations should be performed to inform the decision for bone marrow biopsy and exclude
hematological malignancy. If there is any doubt, a bone marrow biopsy should be performed. Moreover, since bone marrow signal changes may be
a preliminary finding, follow-up of these patients is essential.
Dermatoglyphic Phenotype of a Person As One of the Criteria For Its Identification
Authors: Kotsyubynska Yulya , Voloshynovych Volodymyr , Gunas Valery , Garazdiuk Marta , Fentsyk V. , Liampel V.
Published: March 2024

Introduction. One of the methods used to track the pattern of heredity and variability of human psychophenotypic traits is dermatoglyphic. It is used to study the hereditary patterns that form skin lines on the fingertips, palms, and soles of a person.

The aim of the study to develop expert criteria for the informativeness of dermatoglyphic fingerprints in the system of forensic medical identification of a person.

Materials and methods. The object of the study was fingerprint cards obtained from 460 people (200 women and 260 men) aged 18-59 years living in Ukraine. The dermatoglyphic method and the method of statistical analysis were used.

Results. It has been established that dermatoglyphic features can be congenitally unchanged (pattern type and its orientation, comb and delta count, rudiments and dysplasias);

congenital variables (altitude-latitude index, delta-interphalangeal fold distance, line density); acquired variables (white lines and scars).All these features have not only individual but also group variability.

Conclusion. The proposed forensic classification of dermatoglyphic features does not include individual features of the structure of patterns (minutiae), the appearance of which is largely due to the action of random factors and therefore is valuable for forensic science (fingerprinting).
Features of the Dermatoglyphic Foot Pattern in Suicider Males
Authors: Chadiuk Valeriia , Kozan Nataliia
Published: March 2024

Since suicide is one of the most common types of violent death among people of working age (including military personnel) and children, it is necessary to conduct in-depth studies of the structure of skin patterns in a group of people with completed suicide in order to develop methods of active suicide prevention. In order to determine the propensity to commit suicide, the dermatoglyphs of the distal phalanges and metacarpal pads of the toes of 138 male subjects aged 18 to 59 years who committed suicide and 100 control subjects aged 18 to 59 years were studied. The type of pattern (arc, tibial or fibular loop, curl, complex pattern), delta and comb counts were determined. It was found that the suicide group differs from the control group mainly in a higher number of interruptions (ending X) of the main plantar lines A, B and C; an increase in the frequency of arc patterns on most toes of both feet with a degree of reliability; a decrease in the frequency of curls on the third toe of the left foot to 44.5±11.2 (p<0.001) and an increase in the frequency of this pattern on the second toes of both feet; an increase in the value of the comb count in the area of the tibial edge of the foot, with a decrease in the values near the fibular edge of the foot.