The Significance of Routine Biochemical Markers in Patients with Sepsis
Authors:   Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, P.R. China, Y Meng , Y Wang ,   Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, P.R. China, W Qiao ,   Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, P.R. China, Y Liu ,   State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, P.R. China, L Wang ,   State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, P.R. China, J Fan ,   State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, P.R. China, F Tian ,   Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, P.R. China, X Wang ,   Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, P.R. China, T Zhang ,   State Key Laboratory of Pathogenesis, Prevention and Treatment of High Incidence Diseases in Central Asia, First Affiliated Hospital of Xinjiang Medical University, Urumqi, Xinjiang, 830011, P.R. China, X Ma ,   Clinical Laboratory Center, Tumor Hospital Affiliated to Xinjiang Medical University, Urumqi, Xinjiang, P.R. China
Published: August 2021

Background: Sepsis is a highly complex and fatal syndrome, considered to be the main cause of death in the intensive care unit. Early diagnosis is beneficial to reduce the mortality and improve the prognosis of patients. Therefore, we look forward to finding cheap and fast diagnostic criteria to quickly assess the patient’s condition. Methods: Our study enrolled 499 patients in our hospital from January to 2020, and 96 healthy cases in the same period. Used the diagnostic criteria of bacterial infection, SIRS criteria and Sepsis-2 consensus criteria, 499 patients were divided into 4 groups: sepsis group (n=300), SIRS group (n=151), infection group (n=48). We collected the results of routine laboratory tests, inflammation indicators and blood culture results of these patients. Results: The sepsis group compared with the control group, many indicators had significant statistical differences. D-dimer, CRP and PCT had higher diagnostic efficiency. Compared between the infection group and the SIRS group, PLT and IL-6 were statistically different, and have a certain diagnostic value. Sepsis group VS infection group, WBC, IL-6, NE and TBIL showed significant differences. Among them, NE had the highest diagnostic efficiency and the highest specificity (95.8%). Conclusions: This retrospective study shows that NE, WBC and D-dimer are helpful for early diagnosis of sepsis in which of them D-dimer performs best. WBC and NE can be used to distinguish sepsis from common infection. This result can provide a timely and convenient assessment tool for early diagnosis of sepsis.