bluuebunny/crossref_metadata_2025 huggingface dataset:
Simple modulation of Lissajous MEMS laser beam scanning with reconfigurable structured light patterns for 3D imaging
Authors: Xu Bin , Ji Yao , Xu Chenhao , Zhang Bo , Liu Kai , Li Jinhua
Published: March 2024

Structured light 3D imaging systems commonly employ panel-based projectors or 1-axis MEMS mirrors with beam expander lens to project multi-frame barcodes or dot clouds, addressing challenges posed by objects with multi-scale feature sizes. However, these methods often result in large system volumes due to the required projection multi-lens modules, high hardware costs, or limited light pattern generation capabilities that hindering measurement precision enhancement. This paper introduces an innovative approach to reconfigurable spatial light pattern projection using a single bi-axial MEMS mirror with Lissajous scanning. In contrast to the pixel-by-pixel pre-defined image patterns encoding of conventional 2D laser beam scanning, the proposed method simply aligns the MEMS bi-axial resonance frequencies with laser pulse modulation, enabling the projection of diverse structured light patterns such as stripes, lines, dot matrices, and random dot clouds, which can adapt to different 3D imaging algorithms demands. It eliminates the need for multi-frame encoding and streamlines data caching, simplifies digital logic hardware. A prototype 3D imaging system was developed to demonstrate the mathematical model for laser modulation and the technical feasibility based on the proposed principle. Beyond its lens-free essence, the system supports focal-free optics and a compact projection form factor, which accommodates to a broad range of projection distances and field-of-views based on object’s location. 3D depth map of polynomial surface and blocks objects are extracted through single-frame pattern projection with a relative high accuracy. The presented modulation theory for diverse structured light pattern generation opens avenues for versatile and compact 3D imaging applications of LiDAR and robotic 3D vision.
Growth, spectroscopy and laser operation of Tm,Ho:GdScO3 perovskite crystal
Authors: Eremeev Kirill , Loiko Pavel , Zhao Chengchun , Lin Zhang-Lang , Mateos Xavier , Zin Elabedine Ghassen , Camy Patrice , Braud Alain , Griebner Uwe , Petrov Valentin , Zhang Ge , Li Shanming , Hang Ying , Chen Weidong
Published: March 2024

We report on the growth, polarized spectroscopy and first laser operation of an orthorhombic (space group Pnma) Tm3+,Ho3+-codoped gadolinium orthoscandate (GdScO3) perovskite-type crystal. A single crystal of 3.76 at.% Tm, 0.35 at.% Ho:GdScO3 was grown by the Czochralski method. Its polarized absorption and fluorescence properties were studied revealing a broadband emission around 2 µm. The parameters of the Tm3+ ↔ Ho3+ energy transfer was quantified, P28 = 1.30 × 10−22 cm3µs-1, and P71 = 0.99 × 10−23 cm3µs-1, and the thermal equilibrium lifetime was measured to be 3.5 ms. The crystal-field splitting of Tm3+ and Ho3+ multiplets in Cs symmetry sites of the perovskite structure was determined by low-temperature spectroscopy and the mechanism of spectral line broadening is discussed. The continuous-wave Tm,Ho:GdScO3 laser generated 1.16 W at ∼2.1 µm with a slope efficiency of 50.5%, a laser threshold of 184 mW, a linear laser polarization (
E
||
c
) and a spatially single-mode output. The Tm,Ho:GdScO3 crystal is promising for broadly tunable and femtosecond mode-locked lasers emitting above 2 µm.
Numerical design and characterization of a novel parallel beam combined lens based on X-ray capillary optics
Authors: Hua Lu , Yuan Tianyu , Zhong Yuchuan , Li Huiquan , Hu Jinyue , Sun Tianxi , Sun Xuepeng
Published: March 2024

A novel parallel beam combined lens (PBCL) was designed based on a parabolic monocapillary x-ray lens (PMXRL). The proposed PBCL converted a divergent X-ray beam into a near-solid parallel one, which retains the low divergence characteristics of PMXRL and significantly improves the intensity gain by about one order of magnitude. Compared with the traditional polycapillary parallel x-ray lens (PPXRL), the divergence performance of this lens is improved by an order of magnitude, and the light intensity gain is improved by 3-4 times. In addition, we developed a MATLAB-based visualization tool to simulate X-ray transmission within the PBCL through ray tracing. This tool facilitated the assessment of the PBCL's transmission efficiency and its comparison with conventional PMXRL and the PPXRL. The transport process of the PBCL is systematically investigated under the comprehensive consideration of multiple parameters. This study provided a new idea and theoretical basis for the further development of X-ray modulation technology.
Full-duplex wireless light communication using green laser diodes
Authors: Liang Yingze , Wang Linning , Qi Ziqian , Liu Pengzhan , Zhu Hongbo , Wang Yongjin
Published: March 2024

The integration of wireless light communication into a wireless fidelity (Wi-Fi) module and gateway enables real-time integrated communication networks that satisfy practical application demands. In particular, wireless green light communication tools can operate underwater and in free-space environments. Here, we design, fabricate, and characterize a full-duplex light communication system using green laser diodes (LDs). Operating within the transmission control protocol/internet protocol (TCP/IP), full-duplex wireless data transmission is confirmed in underwater and free-space environments at a communication rate of 10 Mbps. Through connections to a Wi-Fi module and gateway, the system is accessed by the network via the TCP/IPv4 internet scheme, and real-time video transmission is demonstrated.
Heterogeneously integrated InGaP/Si waveguides for nonlinear photonics
Authors: Amores Albert Peralta , Swillo Marcin
Published: March 2024

The heterogeneous integration of III-V semiconductors with the Silicon platform enables the merging of photon sources with Silicon electronics while allowing the use of Silicon mature processing techniques. However, the inherent sufficient quality of III-Vs’ native oxides made imperative the use of deposited interfacial oxide layers or adhesives to permit the bonding. Here we present a novel approach enabling the heterogeneous integration of structured III-V semiconductors on silicates via molecular bonding at 150 °C, much below the CMOS degradation temperature, is presented. The transfer of 235 nm thick and 2 mm long InGaP waveguides with widths of 4.65, 2.6 and 1.22 μm on 4 μm thick Si thermal oxide, with optional SX AR-N 8200.18 cladding, has been experimentally verified. Post-processing of the 1.20 and 0.60 μm input/output tappers has allowed the implementation of double-inverse tapers. The minimal processing requirements and the compatibility with transferring non-cladded structures of the presented technique are demonstrated. The quality of the transferred waveguides bonding interface and their viability for non-linear optics applications has been tested by means of the surface contribution to the optical non-linearity via modal phase-matched second-harmonic generation.
Plasmonic hotspot arrays boost second harmonic generation in thin-film lithium niobate
Authors: Li Zengya , Ye Xiaona , Hu Zhuoran , Li Hao , Liu Shijie , Zheng Yuanlin , Chen Xianfeng
Published: March 2024

Focusing light down to subwavelength scales to enhance the light-matter interaction has been highly sought after, which has promoted significant researches and applications in nanophotonics. Plasmonic nanoantennae are a significant tool to achieve this goal since they can confine light into ultra-small volumes far below the diffraction limit. However, metallic materials have the property of central symmetry, resulting in weak second-order nonlinear effects. Here, we design plasmonic bowtie nanoantennae on thin-film lithium niobate (TFLN) for deep-subwavelength light confinement to boost the second-harmonic generation (SHG) in TFLN via the plasmonic hotspot enhancement. The SHG enhancement factor of about 20 times as compared to unpatterned TFLN is achieved in the experiment when resonantly excited by femtosecond laser. This work proposes a route for subwavelength nonlinear optics on the TFLN platform.
Reconstruction of transparent objects using phase shifting profilometry based on diffusion models
Authors: Zhang Qinghui , Liu Feng , Lu Lei , Su Zhilong , Pan Wei , Dai Xiangjun
Published: March 2024

Phase shifting profilometry is an important technique for reconstructing the three-dimensional (3D) geometry of objects with purely diffuse surfaces. However, it is challenging to measure the transparent objects due to the pattern aliasing caused by light refraction and multiple reflections inside the object. In this work, we analyze the aliasing fringe pattern formation for transparent objects and then, propose to learn the front surface light intensity distribution based on the formation principle by using the diffusion models for generating the non-aliased fringe patterns reflected from the front surface only. With the generated fringe patterns, the 3D shape of the transparent objects can be reconstructed via the conventional structured light. We show the feasibility and performance of the proposed method on the data of purely transparent objects that are not seen in the training stage. Moreover, we found it could be generalized to other cases with local-transparent and translucent objects, showing the potential capability of the diffusion based learnable framework in tackling the problems of transparent object reconstruction.
Kinetics of pair-induced quenching in holmium-doped optical fibers
Authors: Edvardsen André Wean , Holmen Lars Grønmark
Published: March 2024

We present a study of the dynamics of the rapid energy transfer upconversion that occurs within pairs or clusters of holmium ions, commonly referred to as pair-induced quenching. The lifetime of excited holmium ion pairs is determined to be around 0.4 µs from time-resolved fluorescence measurements. We develop a rate equation model that incorporates this lifetime and evaluate numerically and experimentally the consequences this finite intra-cluster upconversion rate has on the performance of a nanosecond-pulsed Ho-doped fiber amplifier. We demonstrate a significant improvement in efficiency by utilizing pulsed pumping on a timescale shorter than the measured excited ion pair lifetime.
Optical wireless communication using a flexible and waterproof perovskite color converter
Authors: Qin Feifei , Chen Feng , Cao Yue , Wang Linning , Wang Chengwei , Liao Yanan , Dai Yuhang , Lu Junfeng , Lan Xinru , Wang Xu , Tang XianWu , Liu Xiaoyan , Zhu Gangyi , Wang Yongjin
Published: March 2024

In this Letter, the CH3NH3PbBr3 nanocrystals (NCs) are embedded into the interstices of the fluorine (polyvinyl fluoride/polyvinylidene fluoride, PVF/PVDF) matrix on polyethylene terephthalate (PET) substrate to introduce new advantages, such as being flexible and waterproof, while maintaining the high optical performance of perovskites. The sample’s photoluminescence (PL) spectra under 325 nm laser is a green emission peaked at 537 nm with full width at half maximum (FWHM) of about 21.2 nm and a fast PL decay time. As a color converter, it shows high optical absorption and can transform light from solar-blind ultraviolet to a blue region into a green region in air, water, and bending conditions. While excited by a 270 nm ultraviolet light-emitting diode (LED), the system’s observed −3 dB bandwidth with the color converter is near 4.4 MHz in air and water conditions with well-eye diagrams at a data rate of 30 Mbps. Finally, we demonstrate an audio transmission application with an ultraviolet light source, a color conversion layer, and a low-cost silicon-based photodetector.
Ultrabroadband two-dimensional electronic spectroscopy in the pump–probe geometry using conventional optics
Authors: Barclay Matthew S. , Wright Nicholas D. , Cavanaugh Paul , Pensack Ryan D. , Martin Eric W. , Turner Daniel B.
Published: March 2024

We report ultrabroadband two-dimensional electronic spectroscopy (2D ES) measurements obtained in the pump–probe geometry using conventional optics. A phase-stabilized Michelson interferometer provides the pump-pulse delay interval, τ1, necessary to obtain the excitation-frequency dimension. Spectral resolution of the probe beam provides the detection-frequency dimension, ω3. The interferometer incorporates active phase stabilization via a piezo stage and feedback from interference of a continuous-wave reference laser detected in quadrature. To demonstrate the method, we measured a well-characterized laser dye sample and obtained the known peak structure. The vibronic peaks are modulated as a function of the waiting time, τ2, by vibrational wave packets. The interferometer simplifies ultrabroadband 2D ES measurements and analysis.
Evolutionary graph theory beyond pairwise interactions: Higher-order network motifs shape times to fixation in structured populations
Authors: Kuo Yang Ping , Carja Oana
Published: March 2024

To design population topologies that can accelerate rates of solution discovery in directed evolution problems or for evolutionary optimization applications, we must first systematically understand how population structure shapes evolutionary outcome. Using the mathematical formalism of evolutionary graph theory, recent studies have shown how to topologically build networks of population interaction that increase probabilities of fixation of beneficial mutations, at the expense, however, of longer fixation times, which can slow down rates of evolution, under elevated mutation rate. Here we find that moving beyond dyadic interactions in population graphs is fundamental to explain the trade-offs between probabilities and times to fixation of new mutants in the population. We show that higher-order motifs, and in particular three-node structures, allow the tuning of times to fixation, without changes in probabilities of fixation. This gives a near-continuous control over achieving solutions that allow for a wide range of times to fixation. We apply our algorithms and analytic results to two evolutionary optimization problems and show that the rate of solution discovery can be tuned near continuously by adjusting the higher-order topology of the population. We show that the effects of population structure on the rate of evolution critically depend on the optimization landscape and find that decelerators, with longer times to fixation of new mutants, are able to reach the optimal solutions faster than accelerators in complex solution spaces. Our results highlight that no one population topology fits all optimization applications, and we provide analytic and computational tools that allow for the design of networks suitable for each specific task.
Bayesian inference of relative fitness on high-throughput pooled competition assays
Authors: Razo-Mejia Manuel , Mani Madhav , Petrov Dmitri
Published: March 2024

The tracking of lineage frequencies via DNA barcode sequencing enables the quantification of microbial fitness. However, experimental noise coming from biotic and abiotic sources complicates the computation of a reliable inference. We present a Bayesian pipeline to infer relative microbial fitness from high-throughput lineage tracking assays. Our model accounts for multiple sources of noise and propagates uncertainties throughout all parameters in a systematic way. Furthermore, using modern variational inference methods based on automatic differentiation, we are able to scale the inference to a large number of unique barcodes. We extend this core model to analyze multi-environment assays, replicate experiments, and barcodes linked to genotypes. On simulations, our method recovers known parameters within posterior credible intervals. This work provides a generalizable Bayesian framework to analyze lineage tracking experiments. The accompanying open-source software library enables the adoption of principled statistical methods in experimental evolution.
Uncharted territories: Solving the mysteries of male meiosis in flies
Authors: Lee LingSze , Rosin Leah F.
Published: March 2024

The segregation of homologous chromosomes during meiosis typically requires tight end-to-end chromosome pairing. However, in Drosophila spermatogenesis, male flies segregate their chromosomes without classic synaptonemal complex formation and without recombination, instead compartmentalizing homologs into subnuclear domains known as chromosome territories (CTs). How homologs find each other in the nucleus and are separated into CTs has been one of the biggest riddles in chromosome biology. Here, we discuss our current understanding of pairing and CT formation in flies and review recent data on how homologs are linked and partitioned during meiosis in male flies.
Hepatitis B virus-related hepatocellular carcinoma has superior overall survival compared with other etiologies
Authors: Yen Yi-Hao , Kee Kwong-Ming , Hu Tsung-Hui , Tsai Ming-Chao , Kuo Yuan-Hung , Li Wei-Feng , Liu Yueh-Wei , Wang Chih-Chi , Lin Chih-Yun
Published: March 2024

Background

Whether the etiology of chronic liver disease (CLD) impacts the overall survival (OS) of patients with hepatocellular carcinoma (HCC) remains unclear. We aim to clarify this issue.

Materials and methods

Between 2011 and 2020, 3941 patients who were newly diagnosed with HCC at our institution were enrolled in this study. In patients with multiple CLD etiologies, etiology was classified using the following hierarchy: hepatitis C virus (HCV) > hepatitis B virus (HBV) > alcohol-related > all negative. All negative was defined as negative for HCV, HBV, and alcohol use disorder.

Results

Among 3941 patients, 1407 patients were classified with HCV-related HCC, 1677 patients had HBV-related HCC, 145 patients had alcohol-related HCC, and 712 patients had all-negative HCC. Using the all-negative group as the reference group, multivariate analysis showed that HBV is an independent predictor of mortality (hazard ratio: 0.856; 95% confidence interval: 0.745–0.983; p = 0.027). Patients with HBV-related HCC had superior OS compared with patients with other CLD etiologies (p<0.001). Subgroup analyses were performed, for Barcelona Clinic Liver Cancer (BCLC) stages 0–A (p<0.001); serum alpha-fetoprotein (AFP) levels≧20 ng/ml (p<0.001); AFP levels < 20 ng/ml (p<0.001); age > 65 years (p<0.001); and the use of curative treatments (p = 0.002). No significant difference in OS between HBV and other etiologies was observed among patients aged ≤ 65 years (p = 0.304); with BCLC stages B–D (p = 0.973); or who underwent non-curative treatments (p = 0.1).

Conclusion

Patients with HBV-related HCC had superior OS than patients with other HCC etiologies.
Temperature difference and systemic risk: Evidence from LASSO-VAR-DY based on China’s pan-financial market
Authors: Jia Kaiwei , Du Yunqing
Published: March 2024

Climate change-induced pan-financial market and the contagion of systemic financial risks are becoming important issues in the financial sector. The paper measures the temperature difference in terms of the degree and direction of deviation of the actual temperature relative to the average temperature of the same historical period. Based on the high-dimensional time-series variable LASSO-VAR-DY framework, we construct a pan-financial market volatility correlation network consisting of 112 Chinese listed companies in banking, insurance, securities, real estate, traditional energy, and new energy, use eigenvector centrality to measure the systematic risk of each firm, and then empirically test the effect of temperature difference on systematic risk under pan-financial market scenario. The results of the study show that (ⅰ) There is a significant difference among the systemic risk of financial sectors such as banking, insurance, and securities in the financial market pan-financial market scenario and the systemic risk when the financial market pan-financial market is not taken into account;(ⅱ) Higher temperature significantly exacerbates systemic financial risk, while colder temperature significantly mitigates systemic risk, but both have an asymmetric effect on systemic risk, and there is sectoral heterogeneity.(ⅲ) From the dynamic evolutionary characteristics, there are significant differences in the response of systemic financial risk to positive and negative temperature shocks;(iv) The results of the systemic risk variance decomposition indicate that the temperature change contributes more to the variance of systemic risk in the banking and securities sectors in pan-financial market;(ⅴ) The contagion source of financial systemic risk shows an obvious path of leaping and changing characteristics, and the contagion source of systemic risk (source of impact) shows the evolution law of "bank → real estate → new energy → temperature difference," which means that the temperature difference has become the contagion source of systemic financial risk. This study provides a reference for preventing and resolving systemic risks under pan-financial market scenario and provides a basis for improving the current macroprudential regulatory framework.
Multidimensional evaluation of the early emergence of executive function and development in Bangladeshi children using nutritional and psychosocial intervention: A randomized controlled trial protocol
Authors: Shama Talat , O’Sullivan Justin M. , Rahman Navin , Kakon Shahria H. , Tofail Fahmida , Hossain Md Iqbal , Zeilani Mamane , Haque Rashidul , Gluckman Peter , Forrester Terrence , Nelson Charles A.
Published: March 2024

Introduction

Reversing malnutrition-induced impairment of cognition and emotional regulation is a critical global gap. We hypothesize that brain-targeted micronutrient supplemented nutritional rehabilitation in children with moderate acute malnutrition, followed by 2 years micronutrient supplementation will impact on the cognition and emotion regulation of these children.

Methods

The primary outcome of this prospective, randomized controlled trial is to study the development of executive functions (EFs) and emotion regulation (ER) in this cohort. Moderate acute malnourished (MAM; WLZ/WHZ <-2 and ≥-3 z-score, and/or 11.5 cm ≤ MUAC < 12.5cm; n = 140)children aged around one year (11m-13m) in Mirpur, Dhaka, Bangladesh will be randomized (1:1) to receive either locally produced Ready to Use Supplementary Food (RUSF) or Enhanced Ready to Use Supplementary Food (E-RUSF) until anthropometric recovery (WLZ/WHZ > -1SD), or for 3 months after enrollment (whichever is earlier). The randomized MAMs groups will be given either Small Quantity Lipid Based Nutrient Supplement (SQLNS) or Enhanced Small Quantity Lipid Based Nutrient Supplement (E-SQLNS), respectively until the end of the 2-year follow up period. Standard psychosocial stimulation will be provided to the MAMs intervention groups. Biological samples will be collected, anthropometric and neurocognitive assessments will be performed at 2 (22m-26m) and 3 (34m-38m) years of age. Two control groups will be recruited: 1), non-malnourished one-year (11m-13m) old children (WLZ/WHZ score>-1SD; n = 70); and 2) three—year (34m-38m) old children (n = 70) with untreated MAM (WHZ <-2 and ≥-3 z-score, and/or 11.5≤MUAC<12.5 cm). The 3-year-old MAM reference group will be assessed once and provided with 2 months of nutritional rehabilitation support (RUSF Nutriset’s Plumpy’Sup™).
A fuzzy interval optimization approach for p-hub median problem under uncertain information
Authors: Wang Yu , Zhu Tao , Yuan Kaibo , Li Xin
Published: March 2024

Stochastic and robust optimization approaches often result in sub-optimal solutions for the uncertain p-hub median problem when continuous design parameters are discretized to form different environmental scenarios. To solve this problem, this paper proposes a triangular fuzzy number model for the Non-Strict Uncapacitated Multi-Allocation p-hub Median Problem. To enhance the quality and the speed of optimization, a novel optimization approach, combining the triangular fuzzy number evaluation index with the Genetic-Tabu Search algorithm, is proposed. During the iterations of the Genetic-Tabu Search algorithm for finding the optimal solution, the fitness of fuzzy hub schemes is calculated by considering the relative positional relationships of triangular fuzzy number membership functions. This approach directly addresses the triangular fuzzy number model and ensures the integrity of information in the p-hub problem as much as possible. It is verified by the classic Civil Aeronautics Board and several self-constructed data sets. The results indicate that, compared to the traditional Genetic Algorithm and Tabu Search algorithm, the Genetic-Tabu Search algorithm reduces average computation time by 49.05% and 40.93%, respectively. Compared to traditional random, robust, and real-number-based optimization approaches, the proposed optimization approach reduces the total cost in uncertain environments by 1.47%, 2.80%, and 8.85%, respectively.
An evolutionary analysis of supply chain collaborative information sharing based on prospect theory
Authors: Liu Meng , Zhai Luyu , Gan Hongcheng
Published: March 2024

In order to delve into the dynamic evolution process and influencing factors of information sharing decisions among stakeholders under supply chain collaboration, this study constructs an evolutionary game model with suppliers and retailers as the primary entities. Within this model, a combined approach of game theory and prospect theory is employed, integrating prospect value functions and weight functions to create an information sharing prospect value matrix. A comprehensive analysis is conducted on the strategic choices and benefits of entities considering the psychological perception of information sharing, and critical factors influencing the stability of information sharing evolution results are explored through numerical simulations using Matlab. The key findings of this study are as follows: Firstly, from the perspective of supply chain collaboration, the probability of entities evolving into information sharing is negatively correlated with the cost of information sharing and positively correlated with the benefits generated by information coordination. Secondly, looking at supply chain collaboration, entities are more likely to engage in information sharing behavior when they exhibit a lower level of risk aversion, indicating greater rationality, when facing profits; conversely, they are more likely to participate in information sharing when they display a higher degree of risk preference, indicating less rationality, in the face of losses. Furthermore, the lesser sensitivity of suppliers and retailers to losses is more likely to drive the system towards an information-sharing state. Based on the primary findings mentioned above, this study offers recommendations for enhancing trust, constructing information exchange platforms, and adjusting psychological awareness. These suggestions contribute to improving information sharing among entities within the supply chain, thus enhancing the overall efficiency and collaboration of the supply chain.
A dynamic traffic signal scheduling system based on improved greedy algorithm
Authors: Sun Guangling , Qi Rui , Liu Yulong , Xu Feng
Published: March 2024

Urbanization has led to accelerated traffic congestion, posing a significant obstacle to urban development. Traditional traffic signal scheduling methods are often inefficient and cumbersome, resulting in unnecessary waiting times for vehicles and pedestrians, exacerbating the traffic situation. To address this issue, this article proposes a dynamic traffic signal scheduling system based on an improved greedy algorithm. Unlike conventional approaches, we introduce a reward function and a cost model to ensure fair scheduling plans. A constraint function is also established, and the traffic signal scheduling is iterated through the feasible matrix using the greedy algorithm to simplify the decision-making process and enhance solution efficiency. Moreover, an emergency module is integrated to prioritize special emergency vehicles, reducing their response time during emergencies. To validate the effectiveness of our dynamic traffic signal scheduling system, we conducted simulation experiments using the Simulation of Urban Mobility (SUMO) traffic simulation suite and the SUMO traffic control interface Traci. The results indicate that our system significantly improves intersection throughput and adapts well to various traffic conditions, effectively resolving urban traffic congestion while ensuring fair scheduling plans.
Industrial technology progress, digital finance development and corporate risk-taking: Evidence from China’s listed firms
Authors: Wu Xiya , Liu Yanghui , Xia Biru
Published: March 2024

Industrial technological progress, as an essential industrial-technological and institutional phenomenon, brings with it the possibility of high profits for firms but also implies new norms and rules of competition, which affect the willingness and propensity of firms to bear the costs of undertaking venture capital projects. This study empirically investigates the causal impact of industrial-technological progress on corporate risk-taking and the mechanism of digital financial growth on the relationship between the two, based on data from China’s A-share listed businesses from 2011 to 2020. This paper finds that (1) industrial technological progress improves enterprise risk-taking levels. Moreover, digital financial development has an incentive effect on industrial technological progress and enterprise risk-taking levels. (2) Industrial technological progress under digital financial development generates financing constraint relaxation effects, input capital return enhancement effects, and innovation performance incentive effects, increasing enterprise risk-taking. (3) The positive moderating effect of digital financial development on the relationship between industrial technological progress and the risk-taking level of enterprises in the eastern regions and enterprises in the high-tech industry is more prominent. The study’s findings provide a theoretical foundation and policy insights on the crucial elements of industrial-technological progress and enterprises’ increased ability to take risks throughout the development of digital finance.
Damage detection of road domain waveform guardrail structure based on machine learning multi-module fusion
Authors: Jin Xiaowei , Gao Mingxing , Li Danlan , Zhao Ting
Published: March 2024

The current highway waveform guardrail recognition technology has encountered problems with low segmentation accuracy and strong noise interference. Therefore, an improved U-net semantic segmentation model is proposed to improve the efficiency of road maintenance detection. The model training is guided by mixed expansion convolution and mixed loss function, while the presence of guardrail shedding is investigated by using partial mean values of gray values in ROI region based on segmentation results, while the first-order detail coefficients of wavelet transform are applied to detect guardrail defects and deformation. It has been determined that the Miou and Dice of the improved model are improved by 8.63% and 17.67%, respectively, over the traditional model, and that the method of detecting defects in the data is more accurate than 85%. As a result of efficient detection of highway waveform guardrail, the detection process is shortened and the effectiveness of the detection is improved later on during road maintenance.
The N-linked glycosylation modifications in the hepatitis B surface protein impact cellular autophagy, HBV replication, and HBV secretion
Authors: Tepjanta Patcharin , Fujiyama Kazuhito , Misaki Ryo , Kimkong Ingorn
Published: March 2024

N-linked glycosylation is a pivotal post-translational modification that significantly influences various aspects of protein biology. Autophagy, a critical cellular process, is instrumental in cell survival and maintenance. The hepatitis B virus (HBV) has evolved mechanisms to manipulate this process to ensure its survival within host cells. Significantly, post-translational N-linked glycosylation in the large surface protein of HBV (LHBs) influences virion assembly, infectivity, and immune evasion. This study investigated the role of N-linked glycosylation of LHBs in autophagy, and its subsequent effects on HBV replication and secretion. LHBs plasmids were constructed by incorporating single-, double-, and triple-mutated N-linked glycosylation sites through amino acid substitutions at N4, N112, and N309. In comparison to the wild-type LHBs, N-glycan mutants, including N309Q, N4-309Q, N112-309Q, and N4-112-309Q, induced autophagy gene expression and led to autophagosome accumulation in hepatoma cells. Acridine orange staining of cells expressing LHBs mutations revealed impaired lysosomal acidification, suggesting potential blockage of autophagic flux at later stages. Furthermore, N-glycan mutants increased the mRNA expression of HBV surface antigen (HBsAg). Notably, N309Q significantly elevated HBx oncogene level. The LHBs mutants, particularly N309Q and N112-309Q, significantly enhanced HBV replication, whereas N309Q, N4-309Q, and N4-112-309Q markedly increased HBV progeny secretion. Remarkably, our findings demonstrated that autophagy is indispensable for the impact of N-linked glycosylation mutations in LHBs on HBV secretion, as evidenced by experiments with a 3-methyladenine (3-MA) inhibitor. Our study provides pioneering insights into the interplay between N-linked glycosylation mutations in LHBs, host autophagy, and the HBV life cycle. Additionally, we offer a new clue for further investigation into carcinogenesis of hepatocellular carcinoma (HCC). These findings underscore the potential of targeting either N-linked glycosylation modifications or the autophagic pathway for the development of innovative therapies against HBV and/or HCC.
Upregulation of Nrf2 in myocardial infarction and ischemia-reperfusion injury of the heart
Authors: Zuberi Sahar , Rafi Hira , Hussain Azhar , Hashmi Satwat
Published: March 2024

Myocardial infarction (MI) is a leading cause of morbidity and mortality in the world and is characterized by ischemic necrosis of an area of the myocardium permanently devoid of blood supply. During reperfusion, reactive oxygen species are released and this causes further insult to the myocardium, resulting in ischemia-reperfusion (IR) injury. Since Nrf2 is a key regulator of redox balance, it is essential to determine its contribution to these two disease processes. Conventionally Nrf2 levels have been shown to rise immediately after ischemia and reperfusion but its contribution to disease process a week after the injury remains uncertain. Mice were divided into MI, IR injury, and sham surgery groups and were sacrificed 1 week after surgery. Infarct was visualized using H&E and trichrome staining and expression of Nrf2 was assessed using immunohistochemistry, Western blot, and ELISA. MI displayed a higher infarct size than the IR group (MI: 31.02 ± 1.45%, IR: 13.03 ± 2.57%; p < 0.01). We observed a significantly higher expression of Nrf2 in the MI group compared to the IR model using immunohistochemistry, spot densitometry of Western blot (MI: 2.22 ± 0.16, IR: 1.81 ± 0.10, Sham: 1.52 ± 0.13; p = 0.001) and ELISA (MI: 80.78 ± 27.08, IR: 31.97 ± 4.35; p < 0.01). There is a significantly higher expression of Nrf2 in MI compared to the IR injury group. Modulation of Nrf2 could be a potential target for therapeutics in the future, and its role in cardioprotection can be further investigated.
Predicting health behaviors during the COVID-19 pandemic: A longitudinal study
Authors: Wollast Robin , Schmitz Mathias , Bigot Alix , Brisbois Marie , Luminet Olivier
Published: March 2024

We investigated the social, emotional, and cognitive predictors of adherence to four health behaviors (handwashing, mask wearing, social contact limitations, and physical distancing) during one critical phase of the COVID-19 pandemic. We collected data (N = 5803, mean age = 53; 57% women) in Belgium at five time points between April and July 2021, a time during which infections evolved from high (third wave of the pandemic) to low numbers of COVID-19 cases. The results show that the social, emotional, and cognitive predictors achieved high levels of explained variance (R2 > .60). In particular, the central components of behavioral change (attitudes, intentions, control, habits, norms, and risk) were the strongest and most consistent predictors of health behaviors over time. Likewise, autonomous motivation and empathetic emotions (e.g., attentive, compassionate) had a positive impact on health behavior adherence, whereas it was the opposite for lively emotions (e.g., active, enthusiastic). These results offer policymakers actionable insights into the most potent and stable factors associated with health behaviors, equipping them with effective strategies to curtail the spread of future infectious diseases.
Neural correlates of bilateral proprioception and adaptation with training
Authors: Rueda Parra Sebastian , Perry Joel C. , Wolbrecht Eric T. , Gupta Disha
Published: March 2024

Bilateral proprioception includes the ability to sense the position and motion of one hand relative to the other, without looking. This sensory ability allows us to perform daily activities seamlessly, and its impairment is observed in various neurological disorders such as cerebral palsy and stroke. It can undergo experience-dependent plasticity, as seen in trained piano players. If its neural correlates were better understood, it would provide a useful assay and target for neurorehabilitation for people with impaired proprioception. We designed a non-invasive electroencephalography-based paradigm to assess the neural features relevant to proprioception, especially focusing on bilateral proprioception, i.e., assessing the limb distance from the body with the other limb. We compared it with a movement-only task, with and without the visibility of the target hand. Additionally, we explored proprioceptive accuracy during the tasks. We tested eleven Controls and nine Skilled musicians to assess whether sensorimotor event-related spectral perturbations in μ (8-12Hz) and low-β (12-18Hz) rhythms differ in people with musical instrument training, which intrinsically involves a bilateral proprioceptive component, or when new sensor modalities are added to the task. The Skilled group showed significantly reduced μ and low-β suppression in bilateral tasks compared to movement-only, a significative difference relative to Controls. This may be explained by reduced top-down control due to intensive training, despite this, proprioceptive errors were not smaller for this group. Target visibility significantly reduced proprioceptive error in Controls, while no change was observed in the Skilled group. During visual tasks, Controls exhibited significant μ and low-β power reversals, with significant differences relative to proprioceptive-only tasks compared to the Skilled group—possibly due to reduced uncertainty and top-down control. These results provide support for sensorimotor μ and low-β suppression as potential neuromarkers for assessing proprioceptive ability. The identification of these features is significant as they could be used to quantify altered proprioceptive neural processing in skill and movement disorders. This in turn can be useful as an assay for pre and post sensory-motor intervention research.
Integrated chronic care models for people with comorbid of HIV and non-communicable diseases in Sub-Saharan Africa: A scoping review
Authors: Chireshe Rumbidzai , Manyangadze Tawanda , Naidoo Keshena
Published: March 2024

Background

Integrated health care is an approach characterized by a high degree of collaboration and communication among health professionals. Integration of HIV/NCD is recommended to enhance the quality of healthcare services being provided. Duplication of limited resources is minimized, and a holistic care approach is promoted by shifting from acute and reactive care to care that embraces patient-centredness that includes promotive health and disease surveillance. The high burden of HIV disease in sub-Saharan Africa (SSA) combined with the increasing prevalence of chronic non-communicable diseases (NCDs) necessitates a review of how health systems has been doing to deliver quality integrated care for people living with HIV (PLWH) and comorbid chronic NCDs.

Methods

A scoping review was conducted to identify and describe all publications on integrated chronic care management models at the primary care level in the SSA context, particularly those that addressed the care of PLHIV with co-morbid chronic NCDs. The inclusion and exclusion criteria were applied, and duplicates were removed.

Results

A total of twenty-one articles were included in the final review. Integrated healthcare systems were reported in only eight SSA countries–(South Africa, Uganda, Kenya, the United Republic of Tanzania, Zambia, Malawi, Zimbabwe and Swaziland). Integrated care systems adopted one of three health models. These included added-on NCD services to previously dedicated HIV care facilities, expansion of primary care facilities to include HIV care and establishment of integrated care services. Short-term benefits included staff capacitation, improved retention of patients and improved screening and detection of NCDs. However, the expansion of existing services resulted in an increased workload with no additional staff. A significant positive change noted by communities was that there was less or no stigmatisation of people living with HIV when attending dedicated HIV clinics.

Conclusion

Evidence of integrated healthcare services for PLWH and co-morbid of NCDs in SSA is scanty. Data on some short-term benefits of integrated care was available, but evidence was absent on the long-term outcomes. Randomized clinical trials with clearly defined comparator groups and standardized measures of HIV and NCD outcomes are needed to demonstrate non-inferiority of integrated against non-integrated care.
Statistical determination of service quality gaps in primary health care in Guayas, Ecuador
Authors: Bustamante U. Miguel A. , Tello Michelle , Carvache-Franco Mauricio , Carvache-Franco Orly , Carvache-Franco Wilmer
Published: March 2024

The present work determines the gaps between expectations and perceptions about the quality of the service that patients and families receive in primary health care (PHC) in Guayas, Ecuador. A descriptive, cross-sectional and non-experimental study was carried out, primarily prospective with respect to expectations and retrospective with respect to perceptions of service quality. For its development, a random sample of 533 users from the northern and southern urban sectors of the city of Guayaquil was determined, who were asked to answer a questionnaire. Their responses were collected using a seven-point scale intended to determine magnitudes of gaps, which were confirmed using the Wilcoxon test. The results reveal a significant gap between women, specifically those over 21 years of age who have studied at the technological and university level, and those who work. In general, the five dimensions of quality present significant gaps, highlighting that the lowest gap occurs when the medical professional listens attentively and treats the patient with kindness. Instead, the largest gap occurs because there are no available or easily accessible times for medical appointments. Finally, the dimension that indicates the gaps that service providers best resolve are the empathy items, recording the smallest deviations; On the contrary, the reliability dimension presents the greatest deviation, thus showing higher degrees of dissatisfaction, in both cases significant.
Early assessment of fungal and oomycete pathogens in greenhouse irrigation water using Oxford nanopore amplicon sequencing
Authors: Kudjordjie Enoch Narh , Schmidt-Høier Anne Saaby , Brøndum Mai-Britt , Johnsen Mads Grønvald , Nicolaisen Mogens , Vestergård Mette
Published: March 2024

Water-borne plant pathogenic fungi and oomycetes are a major threat in greenhouse production systems. Early detection and quantification of these pathogens would enable us to ascertain both economic and biological thresholds required for a timely treatment, thus improving effective disease management. Here, we used Oxford nanopore MinION amplicon sequencing to analyze microbial communities in irrigation water collected from greenhouses used for growing tomato, cucumber and Aeschynanthus sp. Fungal and oomycete communities were characterized using primers that amplify the full internal transcribed spacer (ITS) region. To assess the sensitivity of the MinION sequencing, we spiked serially diluted mock DNA into the DNA isolated from greenhouse water samples prior to library preparation. Relative abundances of fungal and oomycete reads were distinct in the greenhouse irrigation water samples and in water samples from setups with tomato that was inoculated with Fusarium oxysporum. Sequence reads derived from fungal and oomycete mock communities were proportionate in the respective serial dilution samples, thus confirming the suitability of MinION amplicon sequencing for environmental monitoring. By using spike-ins as standards to test the reliability of quantification using the MinION, we found that the detection of spike-ins was highly affected by the background quantities of fungal or oomycete DNA in the sample. We observed that spike-ins having shorter length (538bp) produced reads across most of our dilutions compared to the longer spikes (>790bp). Moreover, the sequence reads were uneven with respect to dilution series and were least retrievable in the background samples having the highest DNA concentration, suggesting a narrow dynamic range of performance. We suggest continuous benchmarking of the MinION sequencing to improve quantitative metabarcoding efforts for rapid plant disease diagnostic and monitoring in the future.
Spatiotemporal mapping of rice acreage and productivity growth in Bangladesh
Authors: Al Mamun Md. Abdullah , Nihad Sheikh Arafat Islam , Sarker Mou Rani , Sarkar Md Abdur Rouf , Hossain Md. Ismail , Kabir Md. Shahjahan
Published: March 2024

Technological advancements have long played crucial roles in rice productivity and food security in Bangladesh. Seasonal variation over time and regional differences in rice production, however, pose a threat to agricultural sustainability but remain unexplored. We performed a spatial-temporal mapping of rice cultivation area, production, and yield from 2006–2007 to 2019–2020 using secondary data for disaggregating 64 districts in Bangladesh. Growth and multivariate approaches were employed to analyze time-series data. Results showed that Mymensingh had the highest rice cultivated area and production, while Bandarban had the lowest. The 14 years highest average rice yield was found in Gopalganj and Dhaka (3.63 tons/ha), while Patuakhali (1.73 tons/ha) had the lowest. For the Aus, Aman, and Boro, the rice cultivation area in 19 districts, 11 districts, and 13 districts declined significantly. The overall rice production increased significantly in most districts. For the Aus, Aman, and Boro seasons, the rice yield in 54, 50, and 37 districts demonstrated a significant upward trend, respectively. The adoption rate of modern varieties has risen dramatically. However, there are notable variances between regions and seasons. A significant increasing trend in Aus (0.007% to 0.521%), Aman (0.004% to 0.039%), and Boro (0.013% to 0.584%) were observed in 28, 34, and 36 districts, respectively, with an increase of 1% adaptation of HYV. Predictions revealed that rice cultivation area and production of Aus, Aman, and Boro seasons will be increased in most of the regions of Bangladesh by 2030. Based on spatiotemporal cluster analysis, the five identified cluster groupings illustrated that clusters lack spatial cohesion and vary greatly seasonally. This suggests increasing rice production by expanding cultivable land, adopting high-yielding varieties, and integrating faster technological advancement in research and extension. The findings will assist scientists in developing region-specific production technologies and policymakers in designing decentral region-specific policies to ensure the future sustainability of rice production.