bluuebunny/crossref_metadata_2025 huggingface dataset:
Dose response relationship between blood concentrations of THC and crash culpability risk: meta-regression of culpability studies
Authors: Albrecht Matthew , Hasan Razi , Kekez Damir , Zhou Huaqiong
Published: July 2024

Recent meta-analyses on the risk associated with the detection of tetrahydrocannabinol (THC) in blood and crash risk indicate a ~10-80% increase in crash culpability for detection of THC. However, the meta-analyses did not analyse a dose-response relationship between blood concentrations of THC and risk necessary to better understand the crash risk associated with THC and to inform public risk tolerances surrounding THC and driving. Here, we leverage these recent meta-analyses to understand whether there is a blood concentration crash culpability risk relationship. We show that crash culpability risk increases with increasing THC concentration, with an inflection around 1.5-3.0 ng/ml where risk begins to increase. There is a doubling of risk around 5 ng/ml, and a potential quadrupling of risk around 10 ng/ml. Conversely, blood THC concentrations below ~1.5 ng/ml indicate practically no risk (<30% increase). More studies are needed to better define risk for the lower and higher bands of blood THC concentrations. Consideration of blood concentration risk relationships are necessary for public discussions surrounding THC and crash risk.
Online experience sharing without explicit social interaction does not foster social bonding
Authors: Wolf Wouter , Dotsobn Kayley
Published: July 2024

Humans have a unique capacity to bond with others through shared experiences, even in the absence of explicit communication. Yet it is unknown whether this capacity is flexible enough to accommodate the different kinds of virtual environments on which we increasingly rely. In the current pre-registered study, we examined whether this capacity still operates effectively on shared screens during non-communicative video mediated interactions, in dyads and in groups. Participants either watched a video on a shared screen together with (pre-recorded) partners or watched individually while their partners attended to something else. Equivalence tests showed that self-reported social bonding scores were practically equivalent between conditions, Thus, in contrast to several in-person studies, no social bonding occurred during these interactions. These results show that, in the absence of explicit communication, some of humans’ most fundamental social bonding mechanisms might not operate as effectively in video mediated social interactions.
Evaluation of freshwater springs utilizing benthic macroinvertebrates as key bioindicators in the Panchadewal Binayak Municipality, Middle Karnali Watershed, Nepal
Authors: Mahato Asha Kumari , Shah Deep Narayan , Tachamo-Shah Ram Devi
Published: July 2024

In the mountainous regions of Nepal, springs are the primary source of freshwater for rural communities and also serve as unique habitats for endemic and threatened aquatic species, particularly macroinvertebrates that are excellent bioindicators of water quality. Therefore, a comprehensive assessment of benthic macroinvertebrates is imperative for species conservation before they face extinction. This study  in Panchadewal Binayak Municipality focused on evaluating the community structure of Benthic Macroinvertebrates and identifying key environmental factors influencing them. A total of 25 springs and 4 streams were selected, all currently in use or with potential for future use. Altogether, 439 benthic macroinvertebrate individuals belonging to 32 families were observed, revealing high richness in Ephemeroptera, Plecoptera, and Trichoptera (EPT) taxa. Most springs were categorized as class II, indicating moderate pollution. Several environmental variables such as turbidity, dissolved oxygen, chloride, nitrate, sodium, iron, and potassium, significantly influenced the community structure. Human activities such as bathing, clothes washing, littering, livestock watering, and agricultural runoff were identified as major stressors. Although none of the springs were classified as critically degraded, the risk of deterioration remains high. This study emphasizes the importance of springs as habitats for a diverse group of benthic macroinvertebrates, providing valuable information for conservationists and resource managers. Informed decisions can now be made to protect these habitats and the associated services they provide in the Panchadewal Binayak Municipality.
Investigation of the Relationships between E-Learning Styles, Educational Technology Self-Efficacy Perceptions and Problem-Solving Skills of Pre-Service Elementary Mathematics Teachers'
Authors: Kaya Deniz , Kutluca Tamer , Dağhan Gökhan
Published: July 2024

This study aims to determine the relationship between pre-service elementary mathematics teachers' e-learning styles, educational technology self-efficacy perceptions, and problem-solving skills. The sample of the study, in which the relational screening model was used, consists of 150 pre-service teachers studying in a state university's elementary mathematics teaching department. Of the participants, 68% (n=102) were female and 32% (n=48) were male. Data collection tools, e-learning styles, education technology self-efficacy, and measurement tools consisting of non-routine problems were used to determine problem-solving skills and an information form. Pearson product-moment correlation technique and multiple linear regression analysis were used to analyze the data set. According to the study's findings, significant relationships were determined between the sub-dimensions of e-learning styles, education technology self-efficacy, and problem-solving skills. Predictive variables consisting of sub-dimensions of e-learning styles and education technology self-efficacy explained 36% of the variance of the problem-solving skill. At the same time, audio-visual learning, verbal learning, active learning, logical learning, modeling digital-age work and learning, designing and developing digital-age learning experiences and assessments, and engaging in professional growth and leadership variables were effective in problem-solving. Finally, according to the findings, some suggestions are presented.
Application of Curriculum and Management in the Existence of Madrasah Diniah Takmiliyah Awaliyah
Authors: Asrin Ahmad , Nahar Syamsu , Nurmawati
Published: July 2024

This study aims to analyze the implementation of the curriculum and management of Madrasah Diniah Takmiliyah Awaliyah (MDTA). This research is literary with a library research approach. Data sources are obtained from written works such as books, articles, etc. Then, the data analysis technique in this research emphasizes the process of comparative inference and analysis of the dynamics of observed phenomena using scientific logic. The research results show that curriculum implementation and management are very important elements for MDTA educational institutions. Researchers agree with several previous research findings, which state that MDTA management includes a curriculum development management process carried out through the stages of planning, organizing, implementing, and evaluating. Furthermore, implementing the curriculum at MDTA is a strategy for achieving the institution's vision, mission, and goals. The curriculum review at MDTA consists of three stages. However, to maintain the existence of MDTA, curriculum uniformity and strengthening aspects of mastering more Islamic sciences are needed. At the same time, more modern MDTA governance or management and complete facilities are needed.
Analisis Perbekalan Operasional Kapal Pole and Line yang Berpangkalan di Pelabuhan Perikanan Samudera (PPS) Bitung, Sulawesi Utara
Authors: Katili Lidya , Putri Elsari Tanjung , Jul Manohas , Silvester Simau , Jenny Manengkey I , Rudi Saranga , Franky Darondo A. , Karyanto Karyanto , Muddin Imam
Published: July 2024

Aktivitas penangkapan ikan di kapal perikanan, termasuk kapal pole and line yang berbasis di Pelabuhan Perikanan Samudera Bitung, memerlukan berbagai jenis perbekalan. Ketersediaan perbekalan ini sangat penting untuk kelancaran operasi penangkapan ikan. Penelitian ini bertujuan untuk mengidentifikasi dan menelaah jenis, jumlah, dan penanganan perbekalan yang dibawa oleh nakhoda atau awak kapal. Pengumpulan data dilakukan melalui observasi, wawancara, dan metode pengambilan sampel secara purposive sampling. Data tersebut dianalisis menggunakan metode deskriptif kuantitatif. Hasil penelitian menunjukkan bahwa persentase jenis perbekalan yang dibawa dari 7 sampel kapal pole and line dengan kapasitas berkisar 64-94 GT yaitu sebanyak 65% termasuk dalam kategori bahan operasional konsumsi (makanan), 22% bahan operasional kapal (solar, oli, air bersih, majun, sarung tangan kerja), dan 13 % bahan operasional lainnya (rokok, obat-obatan, peralatan mandi). Jumlah perbekalan yang dibawa tergantung pada jumlah awak kapal dan durasi perjalanan penangkapan. Proses penanganan perbekalan oleh nelayan di kapal mencakup pengadaan, pemuatan, pemeriksaan, dan penyimpanan bahan-bahan perbekalan tersebut.
Cardiac regeneration and stem cell therapy through the view of design-driven clinical applications cardiology-related practice: current knowledge and future prospects
Authors: Suchkov Sergey
Published: July 2024

Cardiovascular disease is the leading cause of death, with 80% of cases occurring in developing countries. Innovative therapies are required to reduce mortality and limit or abolish the necessity for cardiac transplantation. Over the last decade, stem cells have been a promise for the cure of several diseases not only due to their plasticity but also to their capacity to act in a paracrine manner and influence the affected tissue. Human SC-based therapy derivatives are extremely attractive for therapeutic development because they have direct pharmacologic utility in clinical applications, unlike any other adult cells. Moreover, stem cell-derived paracrine factors have been shown to suppress inflammation and apoptosis, stimulate angiogenesis, and amplify the proliferation and differentiation of resident cardiac stem cells (CSCs). And SC therapies are thus viable alternatives to conventional treatments with substantial therapeutic potential; market opportunities are huge, as multiple product candidates are expected to be approved over the coming decade
Pengaruh model pembelajaran Realistic Mathematic Education berbantuan media Tangram terhadap pemahaman konsep matematika
Authors: Daffa Lala Destiana , Hajron Kun Hisnan , Rahmawati Puji
Published: July 2024

Penelitian ini bertujuan untuk mengetahui ada tidaknya perbedaan model pembelajaran Realistic Mathematic Education berbantuan media tangram  dengan pembelajaran konvensional terhadap pemahaman konsep matematika pada siswa kelas III di SD Negeri 2 Temanggung II Kabupaten Temanggung. Penelitian ini merupakan penelitian eksperimen dengan jenis penelitian Quasi Experimental Design. Sampel yang digunakan yaitu pada kelas 3A dengan jumlah siswa 24 dan kelas 3B dengan jumlah siswa 24. Metode pengumpulan data digunakan menggunakan tes kognitif pretest dan posttest. Uji prasyarat analitif menggunakan uji hipotesis dengan Uji Independent Sample t Test. Hasil penelitian diperoleh data dengan uji independent sample t test yaitu sig. (-2 tailed) sebesar 0,001 <0,05 maka dapat disimpulkan bahwa tedapat perbedaan rata-rata pemahaman konsep matematika siswa untuk pretest dan posttest pada kelas kontrol. Nilai sig. (-2 tailed) sebesar 0,000 <0,05, berdasarkan pada hasil analisis dan pembahasan, terdapat perbedaan skor rata-rata tes kognitif posttest kelas kontrol dan posttest kelas eksperimen yaitu, kontrol 78,83 < eksperimen 87,21. Maka dapat disimpulkan bahwa adanya perbedaan model pembelajaran Realistic Mathematic Education berbantuan media tangram  dengan pembelajaran konvensional terhadap pemahaman konsep matematika.
Peningkatan ketrampilan membaca permulaan menggunakan picture and picture berbantuan media alphabet spinner
Authors: Paramita Diah Ayu , Pradana Agrissto Bintang Aji , Triana Putri Meinita
Published: July 2024

Penelitian ini bertujuan untuk mengetahui pengaruh model pembelajaran Kooperatif Picture and Picture berbantuan media Alphabet Spinner terhadap keterampilan membaca permulaan siswa kelas I. Penelitian ini merupakan jenis penelitian Pre-Experimental Design, dengan model One Group Pretest-Posttest Design. Sampel yang diambil sebanyak 21 siswa yang dijadikan sebagai kelas eksperimen. Teknik pengambilan sampel menggunakan sampling jenuh. Pengumpulan data menggunakan metode tes unjuk kerja. Tes unjuk kerja ini digunakan untuk mengukur sejauh mana siswa dalam keterampilan membaca permulaan sebelum dan sesudah diberi perlakuan. Adapun analisis yang digunakan dalam penelitian ini adalah Paired Sampel T-Test dengan program SPSS Versi 25.0. Hasil penelitian menunjukkan bahwa model pembelajaran Kooperatif Picture and Picture berbantuan media Alphabet Spinner berpengaruh terhadap keterampilan membaca permulaan. Hal tersebut didukung dengan adanya uji hipotesis yang dilakukan dengan uji Paired Sampel T- Test diperoleh Sig. (2-tailed) sebesar 0,000 (0,000<0,005). Hasil dari penelitian ini disimpulkan bahwa penggunaan model pembelajaran Kooperatif Picture and Picture berbantuan Media Alphabet Spinner berpengaruh signifikan terhadap keterampilan membaca permulaan.
Penanaman karakter disiplin siswa di Sekolah Dasar
Authors: Utami Dyah Henny , Purwandari Septiyati , Wijayanto Sukma
Published: July 2024

Tujuan dari penelitian ini adalah untuk mengetahui penanaman karakter disiplin siswa di SD Kartika XII-1 serta faktor pendukung dan penghambat dalam penanamannya. Penelitian ini menggunakan pendekatan kualitatif. Metode pengumpulan data dengan cara wawancara, observasi, dan dokumentasi. Sumber data dalam penelitian ini yaitu sumber data primer dan sekunder. Sumber data primer yaitu kepala sekolah, guru, siswa, dan orang tua siswa sedangkan sumber data sekunder berupa data-data yang memberikan informasi tentang penanaman karakter disiplin siswa di SD Kartika XII-1. Keabsahan data dilihat melalui triangulasi data yaitu triangulasi sumber, triangulasi teknik, dan triangulasi waktu. Teknik analisis data yang digunakan adalah teknik analisis yang dikembangkan oleh  Milles dan Huberman yang terdiri dari pengumpulan data, reduksi data, penyajian data, dan kesimpulan. Hasil penelitian menunjukkan bahwa penanaman karakter disiplin siswa di SD Kartika XII-1 dilakukan melalui 1) Integrasi dalam pembelajaran yang terdiri dari perencanaan, pelaksanaan, dan evaluasi, 2) kegiatan di luar pembelajaran yang dilakukan melalui kegiatan ekstrakurikuler dan kokurikuler, 3) pembiasaan yang dilakukan di dalam kelas dan di luar kelas, 4) keteladanan dari kepala sekolah dan guru. Terdapat faktor pendukung dan penghambat dalam penanaman karakter disiplin siswa di sekolah dasar. Faktor pendukung dalam penanaman karakter disiplin yaitu adanya keinginan dalam diri guru untuk menjadikan siswanya memiliki kedisiplinan yang baik, SD Kartika XII-1 berada di lingkungan akademi militer juga menjadi pendukung dalam menanamkan karakter disiplin siswa. Sedangkan faktor penghambat dalam penanaman karakter disiplin siswa adalah karena kemampuan siswa yang berbeda-beda sehingga menjadi salah satu tantangan guru dalam menanamkannya
Development of a 1kw Prototype Kerosene-Powered Vapour Absorption Refrigerator for Domestic Refrigeration Applications
Authors: Amosun Taiwo Semiu , Omoniyi Kaffo Paul
Published: July 2024

Vapour absorption is an attractive method of utilizing low grade energy directly for cooling. This work attempts to develop a kerosene-powered vapour absorption refrigerator for domestic refrigeration applications. It is designed to comprise five major components: evaporator, absorber, generator, pump and condenser and their capacities were determined to be 80W, 350W, 180W, 20W and 90W respectively.  The refrigerator is a medium-size one and is designed for domestic purposes only. It uses ammonia and water as primary and secondary working fluids. Parts were designed, fabricated and assembled accordingly. Finally, the performance test was carried out and the refrigerator was able to achieve an evaporative temperature of 7oC and had actual coefficient of performance (COP) of 0.16. It also takes 35 minutes to cool 1litre of water at ambient temperature to 0oC.  The operating temperature of the refrigerator is between 7oC to 43oC. General energy equation of the refrigerator gave 875.237KJ.
AUTHENTICATION OF PATCHOULI OIL FROM VARIOUS GROWING REGIONS USING GC-MS METHOD WITH CHEMOMETRIC COMBINATION ON THE PRODUCTS IN THE MARKET
Authors: Nurani Laela Hayu , Guntarti Any , Milanie Rida Dwi , Gandjar Ibnu Gholib , Rais Ichwan Ridwan , Prasasti Dian , Edityaningrum Citra Ariani
Published: July 2024

Adulteration in patchouli oil trade is an ancient practice, where additional substances like turpentine oil are added to increase volume and odor. Therefore, this research aimed to determine the composition of patchouli oil, considering variations in growing regions and potential adulteration in the products available in the market. The analysis was carried out using the Gas Chromatography-Mass Spectrormetry (GC-MS) method with a Principal Component Analysis (PCA) chemometric combination for authentication. The sample obtained from Bantul, Kulon Progo, and Purworejo was isolated through steam and water distillation. Subsequently, it was tested in accordance with SNI standard 06-2385-2006 and analyzed using GC-MS. The results were compared to the products on the market and processed using multivariate chemometric, namely PCA with Minitab 19 software. GC-MS analysis showed the presence of various compounds contained in the oil, including alcohol, alpha-guaiene, beta-humulene, seychellene, trans-caryophyllene, neoalloocimene, and beta-patchoulene. The combination of GC-MS and PCA chemometrics was able to distinguish patchouli oil from others and the products available on the market. PCA chemometric analysis showed that the patchouli oil from various growing regions had the same chemical components as essential oil. Furthermore, PCA chemometric analysis of market products also showed similar results but varied significantly from turpentine oil. This showed that the patchouli oil product available on the market did not contain turpentine oil.
MOUTHWASH FORMULATION OF ONION (ALLIUM CEPA L.) METHANOL EXTRACT FOR INHIBITING THE GROWTH OF STREPTOCCUS MUTANS BACTERIA
Authors: Supriyanto Sugeng , Kiromah Naelaz Zukhruf Wakhidatul , Purwanti Ery , Rahayu Titi Pudji
Published: July 2024

Dental and oral problems experienced a significant increase from 2007 to 2018. Based on the results of basic health research, dental and oral problems increased from 23.2% to 57.6%. Dental caries is ranked sixth with a prevalence of 60% to 80%. The main cause of dental caries is Streptococcus mutans. The use of mouthwash with synthetic active ingredients can cause side effects. In addition, only a few mouthwashes were able to inhibit the growth of Streptococcus mutans bacteria. The purpose of this study was to make a mouthwash formulation from onion methanol extract and to determine its ability to inhibit the growth of Streptococcus mutans bacteria. Three mouthwash formulas were made with 10%, 20% and 30% extract concentrations respectively, then physical evaluation was carried out for 14 days on days 0, 7 and 14. Physical evaluation included stability tests (odor, taste, turbidity and precipitate), pH and diameter of inhibition. The results of the formula stability evaluation on day 14 there was a change in formulas 2 and 3 color, but not in formula 1. This was due to differences in the concentration of extracts and the sappans color stability in the formulas. The pH test results for each formula are in the range of 6.0-6.3. A good mouthwash has a pH close to neutral like the pH of the mouth, which is 6-7. The results of the diameter inhibition test ranged from 6-8 mm. A significant difference was seen between the positive controls with formulas 1 and 3, but there was no significant difference between formulas 1 and 3. The conclusion of this study was that the mouthwash of onion methanol extract had the ability to inhibit the growth of Streptococcus mutans bacteria with moderate strength and the best formula was mouthwash with 10% extract concentration.
EVALUATION OF KNOWLEDGE AND BEHAVIOR ON ANALGESIC SELF-MEDICATION IN HEALTH AND NON-HEALTH STUDENTS AT MUHAMMADIYAH UNIVERSITY, YOGYAKARTA
Authors: Putri Claryza Amelia , Rahajeng Bangunawati
Published: July 2024

Pain is the most common cause that encourages someone to do self-medication. A person's level of knowledge is known to influence a person's behavior in self-medication. The study evaluates the level of knowledge and behavior toward self-medication using analgesics among health and non-health students at the University of Muhammadiyah Yogyakarta. This research uses a non-experimental observational research design with a cross-sectional approach. The sample used was 752 health and non-health students at the University of Muhammadiyah Yogyakarta. The level of knowledge of health students is good, with a percentage of 75.3% good; 21.0% is sufficient; and 3.7% is less, while the level of knowledge of non-health students is adequate, with a percentage of 33.5% good; 50.5% is sufficient; and 16.0% is less. The behavior of health students is good, with 86.7% good, 12.5% adequate, and 0.8% less, while the behavior of non-health students is good, with 80.9% good, 17.5% enough, and 1.6% less. The difference in the level of knowledge and behavior of analgesic self-medication between health and non-health students is quite significant, with the results of the Mann-Whitney test analysis showing a value of 0.000 on the level of knowledge and 0.001 on behavior. The relationship between the level of knowledge and behavior of health students and the Spearman Rank correlation test showed a result of 0.039 with an R-value of 0.107. In contrast, non-health students showed a result of 0.027 with an R-value of 0.114, indicating a significant and weak relationship between both.
THE BENEFITS OF LEARNING ENGLISH IN EARLY CHILDHOOD: POSITIVE AND NEGATIVE EFFECT
Authors: Kuntum Trilestari  , Manurung Ria Maya Lestari , Simangunsong Venny Nurcahaya
Published: July 2024

The study focuses on the crucial role of teaching foreign languages, particularly English, to young children as a means to enhance their knowledge and overall development. Employing a descriptive analysis methodology based on literature studies, the research aims to identify both the positive and negative impacts of introducing English during early childhood. To ensure a structured approach, the study establishes specific criteria as limitations for data collection. The findings reveal that learning English at a young age yields numerous benefits, while also acknowledging potential negative effects. This comprehensive examination of the subject provides valuable insights into the complexities of early language acquisition and its implications for child development. The study's novelty lies in its balanced approach, considering both the advantages and potential drawbacks of early English language education, which can inform educational practices and policies moving forward.
Study of high-temperature oxygen release from strontium cobaltite in quasi-equilibrium regimе
Authors: Popov M. P. , Bagishev A. S. , Nemudry A. P.
Published: July 2024

In the present work, the results of high-temperature oxygen desorption from oxide with mixed conductivity composed of SrCoO3 – δ obtained via original quasi-equilibrium oxygen release technique were shown. Measurements were carried out with a characterized powder sample in a tubular reactor. The equilibrium phase diagram of the oxide in the temperature range and partial pressure of oxygen: 600–850 оC and 0.2–6⋅10-5 atm, respectively, was obtained. With the help of literary data, correlation of phase diagram regions with their corresponding structures was carried out.
Production of ultra-pure hydrogen for fuel cells using a module based on nickel capillaries
Authors: Tropin E. S. , Shubnikova E. V. , Bragina O. A. , Nemudry A. P.
Published: July 2024

In the present work, an experimental module for hydrogen purification based on nickel capillaries was fabricated. The module was tested by varying the temperature, the difference in the partial pressure of hydrogen on the feed and permeate sides of the capillaries. The maximum hydrogen flow obtained using a module based on 7 nickel capillaries with a wall thickness of 50 µm was 37.2 ml/min at a temperature of 900 оС and a hydrogen pressure of 0.9 atm. The stability of the hydrogen flow during the thermal cycling in the temperature range of 600–800 оС for 55 hours is shown.
Study of oxygen transport of microtubular La0.5Sr0.5Fe1 – xNbxO3 – δ membranes
Authors: Kovalev I. V. , Guskov R. D. , Sivtsev V. P. , Gongola M. I. , Popov M. P.
Published: July 2024

Perovskite-like oxides based on lanthanum-strontium ferrites are considered promising electrode materials for use in various types of fuel cells, and the strategy of modifying these materials by partial substitution of iron with highly charged ferroactive cations has proven to be an effective way to increase their chemical stability. In this paper, for the first time, the results of a study of the permeability of microtubular oxygen membranes based on La0.5Sr0.5Fe1 – xNbxO3 – δ oxide are presented. The activation energy of oxide bulk diffusion (20±4 kJ/mol) was found.
Evaluation of the Process of Professional Staff Training in the Republic of Moldova
Authors: Sava L. , Tirsu V. , Petreanu E.
Published: July 2024

This scientific research aims to analyse in depth the process of training and professional development of staff in the Republic of Moldova, a complex field regulated by the provisions of the Labour Code of the Republic of Moldova. Professional training, including both the process by which an employee obtains a certified qualification and continuous professional training, which contributes to the enrichment of existing professional knowledge, are considered essential aspects in the activity of organizations, considering the demands imposed by the competitive economy. Employers have the responsibility to facilitate technical and professional training of employees, aligned with the specific requirements of workplaces, and plans for continuous professional training are developed within organizations.
Within this paper, the main indicators characterizing the process of training and professional development of staff in the Republic of Moldova are analysed. In order to highlight the similarities or differences between these indicators, they are examined by comparing them with data from 2019 and by analysing their evolution between various fields of activity. From a methodological point of view, the research is based on the use of statistical and comparative methods for evaluating the process of staff training in the Republic of Moldova, based on information provided by the National Bureau of Statistics.
Marketing Strategies of Teacher Exchange in University Internationalization
Authors: Chen Z. , Constantin C.
Published: July 2024

In the process of university internationalization, the teacher exchange is inevitable and of great significance. This paper reveals the importance of teacher mobility from the perspective of some representatives of higher education institutions who participated in a qualitative research study. Answers were collected from 30 respondents from 14 countries, who are teachers with experience and practice. The results reveal that teacher exchange is among the top five strategies of universities in their international activity. Finally, some conclusions are drawn regarding the successful experience and activities for teacher exchange proposed.
A Perspective of the Economic Environment on the Research and Development Institute of Transylvania University of Brasov
Authors: Szakal A.C. , Mocanu A.A.
Published: July 2024

This paper addresses the necessity of the relationship between the academic and economic environments. Specifically, this article presents a quantitative research study conducted among representatives of companies from the Central Region of Romania regarding the Research and Development Institute of Transylvania University of Brașov. By conducting this research, valuable insights have been obtained that can be useful both for promoting the institute and for establishing future collaborations between the business and academic sectors.
Cuban Small and Medium Businesses: Innovation; Public Politics and Governance
Authors: Fonseca Daimi
Published: July 2024

The following article aims to explore and bring closer the concepts of public policy, governance and innovation, and the emergence of Cuban SMEs and their current situation. For this, a bibliographic review and field research was carried out where the results indicate that this field of study is oriented to the relationship between the adoption of open innovation and company performance. Theoretical and empirical methods were used, including techniques and tools from administrative sciences and other related specialties. This study focused on the results of Cuban SMEs, from their creation; despite not being relevant at a global level, due to the short initiation time, they do contribute greatly to the country's productivity.
THE INFLUENCE OF VIRAL MARKETING AND ONLINE CUSTOMER REVIEWS ON TIKTOK ON PURCHASING DECISIONS FOR UNIQLO FASHION PRODUCTS AMONG GENERATION Z IN INDONESIA : A STUDY OF THE MEDIATING ROLE OF CONSUMER TRUST
Authors: Syah Irchan Ardian , Salim Muhartini
Published: July 2024

The e-commerce industry in Indonesia has experienced significant growth. Data from the Central Statistics Agency (BPS) shows 17%, with the total number of e-commerce businesses reaching 26.2 million units. This study aims to analyze the influence of viral marketing and online customer reviews on TikTok on the purchase decision of UNIQLO fashion products among Generation Z in Indonesia, considering the mediating role of consumer trust. This study uses quantitative methods by distributing questionnaires to 160 Generation Z respondents who actively use TikTok. This research data was processed using SEM (Structural Equation Modeling) using the SmartPLS4 application. The results show that Viral Marketing has a significant impact on Trust, Online Consumer Reviews has a significant impact on Trust, Trust has a significant impact on Purchasing Decisions, Viral Marketing has a significant impact on purchasing decisions, Viral Marketing has a significant impact on Purchasing Decisions through Trust, Online Consumer Reviews has a significant impact on Purchasing Decisions through Trust. However, the Online Consumer Reviews variable did not significantly affect purchasing decisions. The implication of this research for UNIQLO is that utilizing viral marketing and encouraging positive customer reviews on platforms such as TikTok can be an effective strategy to increase purchase decisions. UNIQLO also needs to communicate values that align with Generation Z preferences, such as sustainability and ethical practices in the fashion industry.
PENGARUH LITERASI KEUANGAN, INKLUSI KEUANGAN DAN MODAL MINIMAL TERHADAP MINAT INVESTASI GENERASI Z INDONESIA DI PASAR MODAL
Authors: Agata Theo Filia , Nurazi Ridwan
Published: July 2024

Penelitian ini bertujuan untuk menentukan pengaruh literasi keuangan, inklusi keuangan, dan modal minimal terhadap minat investasi generasi Z Indonesia di pasar modal. Penelitian ini bersifat kuantitatif dengan menggunakan survey dengan 262 responden yang valid, Model Persamaan Struktural (SEM) dalam SmartPLS 4.0 digunakan untuk analisis. Studi ini mengungkapkan bahwa: 1) variabel Literasi keuangan memiliki pengaruh positif signifikan terhadap minat investasi dengan koefisien sebesar 0.179, T-statistik 3.000, dan nilai p sebesar 0.003. 2) Variabel Inklusi keuangan memiliki pengaruh positif signifikan terhadap minat investasi dengan koefisien sebesar 0.278, T-statistik 4.974, dan nilai p sebesar 0.000. 3) variabel Modal minimal memiliki pengaruh paling besar dan signifikan terhadap minat investasi dengan koefisien sebesar 0.501, T-statistik 7.112, dan nilai p sebesar 0.000. Temuan ini mengindikasikan bahwa ketiga variabel tersebut secara positif mempengaruhi minat investasi di kalangan generasi Z, dengan modal minimal sebagai faktor yang paling dominan. Selanjutnya Hasil uji F Penelitian ini memberikan pemahaman yang lebih baik tentang faktor-faktor yang memengaruhi minat investasi generasi Z. Dengan pemahaman ini, pemerintah, lembaga keuangan, dan pendidikan dapat merancang program-program yang lebih efektif untuk meningkatkan literasi keuangan dan inklusi keuangan, serta mengurangi batasan modal minimal untuk investasi. Hal ini bisa mendorong peningkatan investasi dari generasi Z, yang pada gilirannya dapat memberikan dorongan signifikan bagi pertumbuhan ekonomi negara.
ANALISIS CURRENT RATIO (CR), DEBT TO EQUITY RATIO (DER) DAN EARNINGS PER SHARE (EPS) TERHADAP HARGA SAHAM PT WASKITA KARYA TBK PERIODE 2015-2023
Authors: Ardillah Nurul , Herlinawati Erna
Published: July 2024

Tujuan dari penelitian ini adalah untuk menguraikan pengaruh CR, DER, dan EPS terhadap harga saham PT Waskita Karya Tbk selama periode 2015-2023. Data sekunder pada penelitian ini bersumber dari laporan keuangan tahunan PT Waskita Karya Tbk. Hasil pengujian hipotesis secara parsial membuktikan bahwa CR tidak memiliki pengaruh signifikan terhadap harga saham, sementara DER membuktikan adanya pengaruh secara negatif serta signifikan dan EPS berdampak positif dan juga signifikan terhadap harga saham. Hasil pengujian secara simultan menunjukkan bahwa CR, DER, dan EPS secara simultan berpengaruh terhadap Harga Saham pada PT Waskita Karya Tbk periode 2015-2023. Hasil analisis Adjusted R Square sebesar 0,858 mengindikasikan bahwa sekitar 85,8% dari variasi dalam Harga Saham dapat dijelaskan oleh variasi dalam CR, DER, dan EPS.
PENGARUH PENGEMBANGAN PARIWISATA DAN UMKM TERHADAP PENGEMBANGAN WILAYAH KABUPATEN KARO
Authors: Rosari Dina
Published: July 2024

Pemgembangan wilayah Kabupaten Karo dapat dilakukan dengan xara pengembangan pariwisata dan UMKM. Pengembangan wilayah memiliki peranan penting dalam pembangunan daerah, hal ini dapat lebih dengan adanya potensi alam dan budaya yang yang dapat dijadikan modal dalam pengembangan pariwisatanya. Tujuan pengembangan pariwisata secara khusus adalah untuk meningkatkan pendapatan daerah dan pendapatan masyarakat pada umumnya, seperti adanya perluasan kesempatan/lapangan kerja dan terbukanya kesempatan berusaha melalui kegiatan-kegiatan industri-industri penunjang seperti penginapan, rumah makan/restoran, souvenir, dan industri-industri sampingan lainnya. Penelitan ini menggunakan metode penelitian regresi linier berganda. Dari penelitian ini diperoleh pengaruh pengembangan pariwisata dan UMKM berpengaruh positif dan signifikan terhadap pengembangan wilayah Kabupaten Karo.
Anexo III
Authors: Gutiérrez C. , Martín I. , Obregón T.
Published: July 2024

Análisis de industria lítica: Proyecto alto almanzora: Estudio de la industria lítica
Modeling and analysis of a prosthetic foot: A numerical simulation case study
Authors: Abdullah Asmaa Muneam , Ali Hamzah Adawiya , Al-sharify Noor T. , Kadhim Fahad Mohanad
Published: July 2024

BACKGROUND: The prosthetic foot is an essential component of the prosthetic limb used by people who suffer from amputation. The prosthetic foot or limb is expensive in developing countries and cannot be used by most people with special needs. OBJECTIVE: In this study, an uncomplicated prosthetic foot is designed that can be manufactured at low costs using 3D printer technology and can be provided to a wide range of amputees. The foot was designed using CAD software and analyzed using ANSES. METHODS: Carbon fiber material was chosen to be suitable for the manufacturing process using 3D printer technology. The selected material was tested in tensile and fatigue tests to determine its mechanical properties. The numerical analysis was carried out assuming the use of an artificial foot by a patient weighing 85 kg. RESULTS: The results showed that the material proposed for manufacturing has good mechanical properties for this application. The results of the engineering analysis also showed that the model has successfully passed the design process and is reliable for use by amputees. CONCLUSION: The success model designed in this study in the numerical analysis process gives reliability to the use of this design to manufacture the prosthetic foot.
The Effects of Neuropsychiatric Symptom Clusters in People with Dementia on Family Caregiver Burden
Authors: van den Kieboom Robin , Snaphaan Liselore , Mark Ruth , van Assen Marcel , Bongers Inge
Published: July 2024

Background:

Neuropsychiatric symptoms are a robust risk factor for caregiver burden in family dementia caregivers. By grouping these symptoms, clinical interpretations regarding neuropsychiatric symptoms may facilitated because different groups of symptoms may require a different approach for intervention, thereby reducing caregiver burden.

Objective:

As clustering of neuropsychiatric symptoms could be clinically relevant, we aimed to explore the effects of these clusters on burden in family dementia caregivers.

Methods:

152 family dementia caregivers were included. Caregiver burden was measured using the Ervaren Druk door Informele Zorg (EDIZ)/Self-Perceived Pressure from Informal Care, a Dutch questionnaire. Caregivers also reported the neuropsychiatric symptoms and functional impairments in daily activities of the people with dementia they cared for. Multiple regression analyses were used in this cross-sectional study.

Results:

Adjusted for functional impairments and sociodemographic variables, neuropsychiatric symptoms were associated with more caregiver burden ( p < 0.001). However, this association did not differ between the three neuropsychiatric symptom clusters ( p = 0.745).

Conclusions:

Neuropsychiatric symptoms were associated with more family caregiver burden, but no conclusive evidence was found that this association differed for the three clusters. Clustering of neuropsychiatric symptoms is, however, worth exploring further in future studies with more participants. If specific links are found, these could be targeted in clinical practice in order to prevent, reduce and/or postpone caregiver burden.
The Use of Event Related Potentials to Predict Amyloid PET Status Among Patients from a Memory Disorders Clinic
Authors: Marin Anna , Turk Katherine W. , Schiloski Kylie , Vives-Rodriguez Ana , Suh Cheongmin , Uppal Prayerna , Dwyer Brigid , Palumbo Rocco , Budson Andrew E.
Published: July 2024

Background:

Amyloid positron emission tomography (PET) scans provide in vivo evidence of Alzheimer’s disease (AD); however, their high cost limits their use in standard clinical care. Event related potentials (ERPs) may represent an inexpensive and non-invasive additional method for detecting AD pathology.

Objective:

We investigated whether ERPs, along with neuropsychological data, serve as predictors of amyloid PET status in patients with memory complaints.

Methods:

Veterans aged 50–100 were recruited from a memory disorders clinic. Participants underwent a neuropsychological battery and an ERP auditory oddball protocol. Twenty-eight patients had a positive amyloid PET scan, and thirty-nine patients had a negative scan.

Results:

ERP-P200 target amplitude and P200 standard latency were predictors of amyloid PET status. When submitting to ROC analysis, P200 standard latency exhibited the highest specificity and sensitivity in predicting amyloid PET positivity, correctly classifying the amyloid PET status for 86% of patients.

Conclusions:

ERP-P200 measures are strong indicators of amyloid-β presence in patients from a memory disorder clinic. Increased P200 amplitude and decreased P200 latency in patients with a positive amyloid PET scan may be attributed to hyperactivation of perceptual bottom-up processes compensating for AD-related synaptic loss in the fronto-parietal networks.
Exploring the Genetic Heterogeneity of Alzheimer’s Disease: Evidence for Genetic Subtypes
Authors: Elman Jeremy A. , Schork Nicholas J. , Rangan Aaditya V. ,   for the Alzheimer’s Disease Neuroimaging Initiative
Published: July 2024

Background:

Alzheimer’s disease (AD) exhibits considerable phenotypic heterogeneity, suggesting the potential existence of subtypes. AD is under substantial genetic influence, thus identifying systematic variation in genetic risk may provide insights into disease origins.

Objective:

We investigated genetic heterogeneity in AD risk through a multi-step analysis.

Methods:

We performed principal component analysis (PCA) on AD-associated variants in the UK Biobank (AD cases = 2,739, controls = 5,478) to assess structured genetic heterogeneity. Subsequently, a biclustering algorithm searched for distinct disease-specific genetic signatures among subsets of cases. Replication tests were conducted using the Alzheimer’s Disease Neuroimaging Initiative (ADNI) dataset (AD cases = 500, controls = 470). We categorized a separate set of ADNI individuals with mild cognitive impairment (MCI; n = 399) into genetic subtypes and examined cognitive, amyloid, and tau trajectories.

Results:

PCA revealed three distinct clusters (“constellations”) driven primarily by different correlation patterns in a region of strong LD surrounding the MAPT locus. Constellations contained a mixture of cases and controls, reflecting disease-relevant but not disease-specific structure. We found two disease-specific biclusters among AD cases. Pathway analysis linked bicluster-associated variants to neuron morphogenesis and outgrowth. Disease-relevant and disease-specific structure replicated in ADNI, and bicluster 2 exhibited increased cerebrospinal fluid p-tau and cognitive decline over time.

Conclusions:

This study unveils a hierarchical structure of AD genetic risk. Disease-relevant constellations may represent haplotype structure that does not increase risk directly but may alter the relative importance of other genetic risk factors. Biclusters may represent distinct AD genetic subtypes. This structure is replicable and relates to differential pathological accumulation and cognitive decline over time.
Early Astrocytic Dysfunction Is Associated with Mistuned Synapses as well as Anxiety and Depressive-Like Behavior in the AppNL-F Mouse Model of Alzheimer’s Disease
Authors: Portal Benjamin , Södergren Moa , Parés i Borrell Teo , Giraud Romain , Metzendorf Nicole G. , Hultqvist Greta , Nilsson Per , Lindskog Maria
Published: July 2024

Background:

Alzheimer’s disease (AD) is the most common neurodegenerative disease. Unfortunately, efficient and affordable treatments are still lacking for this neurodegenerative disorder, it is therefore urgent to identify new pharmacological targets. Astrocytes are playing a crucial role in the tuning of synaptic transmission and several studies have pointed out severe astrocyte reactivity in AD. Reactive astrocytes show altered physiology and function, suggesting they could have a role in the early pathophysiology of AD.

Objective:

We aimed to characterize early synaptic impairments in the App NL- F knock-in mouse model of AD, especially to understand the contribution of astrocytes to early brain dysfunctions.

Methods:

The App NL- F mouse model carries two disease-causing mutations inserted in the amyloid precursor protein gene. This strain does not start to develop amyloid-β plaques until 9 months of age. Thanks to electrophysiology, we investigated synaptic function, at both neuronal and astrocytic levels, in 6-month-old animals and correlate the synaptic activity with emotional behavior.

Results:

Electrophysiological recordings in the hippocampus revealed an overall synaptic mistuning at a pre-plaque stage of the pathology, associated to an intact social memory but a stronger depressive-like behavior. Astrocytes displayed a reactive-like morphology and a higher tonic GABA current compared to control mice. Interestingly, we here show that the synaptic impairments in hippocampal slices are partially corrected by a pre-treatment with the monoamine oxidase B blocker deprenyl or the fast-acting antidepressant ketamine (5 mg/kg).

Conclusions:

We propose that reactive astrocytes can induce synaptic mistuning early in AD, before plaques deposition, and that these changes are associated with emotional symptoms.
Time to Dementia Diagnosis Among Veterans with Comorbid Insomnia and Depressive Episodes
Authors: Bozzay Melanie L. , Joyce Hannah E. , Jiang Lan , De Vito Alyssa N. , Emrani Sheina , Browne Julia , Bayer Thomas A. , Quinn McKenzie J. , Primack Jennifer M. , Kelso Catherine M. , Wu Wen-Chih , Rudolph James L. , McGeary John E. , Kunicki Zachary J.
Published: July 2024

Background:

Older adults with heart failure are at elevated risk of Alzheimer’s disease and related dementias (AD/ADRD). Research suggests that insomnia and depressive episodes contribute somewhat dissociable impacts on risk for AD/ADRD in this patient population, although the temporal ordering of effects is unknown.

Objective:

This study examined time to dementia diagnosis among patients with comorbid insomnia and/or depressive episodes in an epidemiological sample.

Methods:

Secondary data analyses were conducted using a cohort study of 203,819 Veterans with a primary admission diagnosis of heart failure in 129 VA Medical Centers.

Results:

Patients with diagnoses of both insomnia and depressive episodes had the shortest time to a dementia diagnosis at both 1-year (Hazard ratio = 1.43, 95% CI [1.36, 1.51]) and 3-year follow-up time points (Hazard ratio = 1.40, 95% CI [1.34, 1.47]) versus patients with one or neither comorbidity.

Conclusions:

Individuals with both comorbidities had the shortest time to dementia onset. Screening for these comorbidities may help to identify patients at elevated risk of dementia who could benefit from enhanced monitoring or early intervention strategies for more rapid detection and management of dementia symptoms.
Inconsistent Music-Based Intervention Reporting in Dementia Studies: A Systematic Mapping Review
Authors: Lepping Rebecca J. , Hess Benjamin J. , Taylor Jasmine M. , Hanson-Abromeit Deanna , Williams Kristine N.
Published: July 2024

Background:

Recent research has shown beneficial results for music-based interventions (MBIs) for persons living with Alzheimer’s disease and related dementias (AD/ADRD), but reports often lack sufficient detail about the MBI methodology, which reduces replicability. A detailed checklist for best practices in how to report MBIs was created in 2011 by Robb and colleagues to remedy the lack of detail in MBI descriptions. The implementation of the checklist specifically in AD/ADRD research has not been established. Given the complexity of music and the variety of uses for research and health, specific MBI descriptions are necessary for rigorous replication and validation of study results.

Objective:

This systematic mapping review utilized the “Checklist for Reporting Music-Based Interventions” to evaluate the current state of MBI descriptive specificity in AD/ADRD research.

Methods:

Research articles testing MBIs and reviews of MBI efficacy published between January 2015 and August 2023 were scored using the checklist and the results were summarized.

Results:

Forty-eight studies were screened, and reporting was inconsistent across the 11 checklist criteria. Ten out of 48 studies fully reported more than 5 of the 11 criteria. Only one of the 11 scoring criteria was at least partially reported across 47 of 48 studies.

Conclusions:

Thorough reporting of intervention detail for MBIs remains limited in AD/ADRD MBI research. This impedes study validation, replication, and slows the progress of research and potential application of music in practice. Greater implementation of the reporting guidelines provided by Robb and colleagues would move the field of MBI research for AD/ADRD forward more quickly and efficiently.