bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential Receptors for Targeted Imaging of Lymph Node Metastases in Penile Cancer
Authors: van der Fels Christa A. M. , Palthe Selma , Buikema Henk , van den Heuvel Marius C. , Leliveld Annemarie , de Jong Igle Jan
Published: September 2020

Imaging modalities using tumor-directed monoclonal antibodies may be of value to improve the pre- and intraoperative detection and resection of lymph node (LN) metastatic disease in penile squamous cell carcinoma (PSCC). We investigated the expression of prostate-specific membrane antigen (PSMA), vascular endothelial growth factor (VEGF), epidermal growth factor receptor (EGFR) and epithelial cell adhesion molecule (EpCAM) to analyze their potency for diagnostic applications. Antigen expression was determined in primary tumors and LNs with and without metastases of 22 patients with PSCC. The total immunostaining score (TIS, 0–12) was determined as the product of a proportion score (PS, 0–4) and an intensity score (IS, 0–3). EGFR and VEGF expression were high in primary tumor (median TIS 8) and LN metastases (median TIS 6 and 8, respectively). No EGFR expression was seen in LNs without metastases. However, LNs without metastases did show VEGF expression (median TIS 6). No EpCAM or PSMA expression was seen in PSCC. This study shows that VEGF and EGFR expression is moderate to high in LN metastases of PSCC. Both VEGF and EGFR warrant further clinical evaluation to determine their value as a target for pre- and intraoperative imaging modalities in the detection of LN metastases in PSCC.
Investigating the Influence of Inverse Preferential Attachment on Network Development
Authors: Siew Cynthia S. Q. , Vitevitch Michael S.
Published: September 2020

Recent work investigating the development of the phonological lexicon, where edges between words represent phonological similarity, have suggested that phonological network growth may be partly driven by a process that favors the acquisition of new words that are phonologically similar to several existing words in the lexicon. To explore this growth mechanism, we conducted a simulation study to examine the properties of networks grown by inverse preferential attachment, where new nodes added to the network tend to connect to existing nodes with fewer edges. Specifically, we analyzed the network structure and degree distributions of artificial networks generated via either preferential attachment, an inverse variant of preferential attachment, or combinations of both network growth mechanisms. The simulations showed that network growth initially driven by preferential attachment followed by inverse preferential attachment led to densely-connected network structures (i.e., smaller diameters and average shortest path lengths), as well as degree distributions that could be characterized by non-power law distributions, analogous to the features of real-world phonological networks. These results provide converging evidence that inverse preferential attachment may play a role in the development of the phonological lexicon and reflect processing costs associated with a mature lexicon structure.
Repurposing Fly Ash Derived from Biomass Combustion in Fluidized Bed Boilers in Large Energy Power Plants as a Mineral Soil Amendment
Authors: Jarosz-Krzemińska Elżbieta , Poluszyńska Joanna
Published: September 2020

This research involved studying the physico-chemical parameters of fly ash derived from the combustion of 100% biomass in bubbling and circulating fluidized bed boilers of two large energy plants in Poland. Chemical composition revealed that ash contains substantial amounts of CaO (12.86–26.5%); K2O (6.2–8.25%); MgO (2.97–4.06%); P2O5 (2–4.63%); S (1.6–1.83%); and micronutrients such as Mn, Zn, Cu, and Co. The ash from the bubbling fluidized bed (BFB) was richer in potassium, phosphorus, CaO, and micronutrients than the ash from the circulating fluidized bed (CFB) and contained cumulatively less contaminants. However, the BFB ash exceeded the threshold values of Cd to be considered as a liming amendment. Additionally, according to our European Community Bureau of Reference (BCR) study Pb and Cd were more mobile in the BFB than in the CFB ash. Except for a low nitrogen content, the ash met the minimum requirements for mineral fertilizers. Acute phytotoxicity revealed no inhibition of the germination and seed growth of Avena sativa L. and Lepidium sativum plants amended with biomass ash. Despite the fact that low nitrogen content excludes the use of biomass fly ash as a sole mineral fertilizer, it still possesses other favorable properties (a high content of CaO and macronutrients), which warrants further investigation into its potential utilization.
Load Management Strategies to Increase Electric Vehicle Penetration—Case Study on a Local Distribution Network in Stockholm
Authors: Topel Monika , Grundius Josefine
Published: September 2020

As part of decarbonization efforts, countries are adapting their energy policies accordingly. Sweden has established ambitious energy goals, which include CO2 emissions reduction in the transport sector and high integration of renewables in the electricity sector. Coupling the two can be an enabling force towards fossil freedom. An increased share of electric vehicles is therefore a promising solution in this regard. However, there are challenges concerning the impact that a surge of electric vehicles would have on the electric infrastructure. Moreover, in Stockholm there is a shortage of power capacity due to limitations in the national transmission infrastructure, which further aggravates the situation. This paper develops a scenario-based simulation study to evaluate the impact of electric vehicle loads on the distribution grid of a Stockholm neighborhood. In this process, limiting factors and bottlenecks in the network were identified as being related to the peak power and transformer capacities for the years of 2025 and 2031. Two load management strategies and their potential to mitigate the power peaks generated from uncontrolled charging were investigated for the critical years.
Technical Measures to Mitigate Load Fluctuation for Large-Scale Customers to Improve Power System Energy Efficiency
Authors: Lee Yongsik , Lee Hyunchul , Gim Jaehyeon , Seo Inyong , Lee Guenjoon
Published: September 2020

Industrial equipment such as electric arc furnaces and steel mills are often associated with rapid and high load disturbances, so their power systems require additional control equipment to limit the frequency. However, proper ancillary service fees are not paid in these cases with extreme and variable load demands. The frequency regulation reserve equipment adds to power generation costs. Therefore, variable power generation loads lead to increases in the cost of energy production. We propose a load frequency control method that is applied on the customer end instead of the power supply end to reduce the operating reserve required to improve the energy efficiency of the power system. We analyzed the load fluctuation of steel mill customers using real data sampled at two-second intervals from the energy management system in Korea. We developed an automatic generation control program to simulate the power system’s frequency characteristics. We also propose compensation techniques for mitigation of the system’s frequency deviation at the customer end based on an energy storage system, pump storage hydro generator, customer generator, and plant process adjustment. To recover the frequency deviation, we calculated the compensation facility capacity and analyzed static characteristics, and we proved the feasibility via simulations.
Enrichment of Nb-Ta-Zr-W-Li in the Late Carboniferous Coals from the Weibei Coalfield, Shaanxi, North China
Authors: Li Jing , Zhuang Xinguo , Querol Xavier , Moreno Natalia , Yang Guanghua , Pan Lei , Li Baoqing , Shangguan Yunfei , Pan Zhejun , Liu Bo
Published: September 2020

Mineralogical and geochemical characteristics of coals provide crucial information on their potential clean, efficient, and integrated utilization. In this paper, the mineralogical and geochemical behaviors of the No. 5 coals of the Taiyuan Formation in the Weibei Coalfield, North China, were investigated, and their geological controlling factors were subsequently discussed. The minerals in the Weibei coals mainly consist of kaolinite (8.3%), calcite (5.0%), and pyrite (3.1%), with minor proportions of tobelite (2.9%), dolomite (1.7%), quartz (1.8%), and traces of siderite (0.4%) and gypsum (0.6%). Several critical elements, including Nb (19.8 mg/kg), Ta (3.6 mg/kg), Zr (71.0 mg/kg) and Li (32.3 mg/kg), occur at concentrations higher than those averages for world hard coals, making the Weibei coals potential sources of these critical elements. Several factors, terrigenous material, seawater invasion, and hydrothermal fluids are responsible for these mineralogical and geochemical characteristics. The L-type rare earth elements and yttrium (REE-Y) enrichment in the roofs and partings, Al2O3-TiO2 and Zr/TiO2-Nb/Y plots, and negative Eu and weak negative Ce anomalies in the Weibei coals indicate a felsic-intermediate dominated sediment provenance primarily derived from the Qilian-Qinling Oldland on the South. Marine bioclastic limestone, negative Ce and positive Y anomalies in coals imply the influence of seawater on the Weibei coals. Last but not least, the cleat-infilling and/or fracture-infilling calcite, pyrite, barite, and tobelite as well as the positive Eu and Gd anomalies, H-type, and M-type REE-Y enrichment patterns suggest the influence of hydrothermal fluids, which lead to re-distribution of some critical elements from roof and parting to the underlying coal seam.
Characteristic Analysis of Water Quality Variation and Fish Impact Study of Fish-Lighting Complementary Photovoltaic Power Station
Authors: Li Peidu , Gao Xiaoqing , Jiang Junxia , Yang Liwei , Li Yujie
Published: September 2020

Fish-lighting complementary photovoltaic power station organically combines aquaculture and renewable energy. In this study we aimed to develop a solar photovoltaic that is not confined to land. We used a shade net to simulate photovoltaic panels, and studied the effects of different proportions of photovoltaic panels on water and fish. The results showed that the average light intensity of the unshaded area and the shaded area were 16,661.7 Lux and 2437.0 Lux. The average light intensity of the shaded area was 85.4% lower than that of the unshaded area. The effective range of the shaded area for the light intensity of the water layer was 0 cm~30 cm. The temperature and pH in the water body showed a linear decreasing trend with the increase of the photovoltaic deployment ratio, and the dissolved oxygen showed an inverted “U”-shaped change characteristic, but this effect was limited. When the photovoltaic deployment ratio was 25% to 75%, the dissolved oxygen in the water body increases by an average of 2.37% compared to the unshaded area. The appropriate proportion of photovoltaic deployment did not affect the dissolved oxygen content in the water body. When the photovoltaic deployment ratio reached 75%, the number of algae species and algae biomass was the largest, and the fish production was the highest at 8094.6 kg·acre−1, which is an increase of 166.2 kg·acre−1 compared to the average yield in unshaded areas. Therefore, photovoltaic layout will not affect the growth of fish, and the proportion of 75% is the best layout choice.
Production of Proteins prM/M and E of Dengue Virus-3 in Pichia pastoris: Simplified Purification and Evaluation of Their Use as Antigens in Serological Diagnosis of Dengue
Authors: Teixeira Michelle D. O. , Dias Roberto S. , Prates John W. O. , Monteiro Juliana M. C. , Xisto Mariana F. , da Silva Cynthia C. , De Paula Sérgio O.
Published: September 2020

Dengue is a major arbovirus affecting humans today. With the growing number of cases, it is essential to have large-scale production of antigens for the development of diagnostic kits for the rapid detection of patients infected by the virus and consequent proper medical intervention for them. In this work, we express the prM/M and E proteins of dengue virus-3 in yeast Pichia pastoris KM71H. The proteins were produced in soluble form in the supernatant of the culture and were purified by precipitation with ammonium sulfate. The fraction of 80% of ammonium sulfate was used as an antigen in an indirect enzyme-linked immunosorbent assay (ELISA), providing a sensitivity of 82.61% and a specificity of 89.25%. Thus, the methodology proposed here showed promise for obtaining antigens of dengue viruses and creating quick and inexpensive diagnostic tests, which is of great value since large portions of the areas affected by this disease are economically neglected.
Saccharomyces cerevisiae Strain Diversity Associated with Spontaneous Fermentations in Organic Wineries from Galicia (NW Spain)
Authors: Castrillo David , Neira Noemi , Blanco Pilar
Published: September 2020

Yeast play an essential role in wine quality. The dynamics of yeast strains during fermentation determine the final chemical and sensory characteristics of wines. This study aims to evaluate the Saccharomyces cerevisiae strains diversity in organic wineries from Galicia (NW Spain). Samples from spontaneous fermentations were taken in five wineries over three consecutive years (2013 to 2015). The samples were transported to the laboratory and processed following standard methodology for yeast isolation. S. cerevisiae strains were differentiated by mDNA-RFLPs. A total of 66 different strains were identified. Some of them presented a wide distribution and appeared in several wineries. However, other strains were typical from a specific winery. Similarity analysis using two different statistical tests showed significant differences in strain diversity among wineries. The results also revealed high biodiversity indexes; however, only some strains showed an important incidence in their distribution and frequency. Our findings confirmed that spontaneous fermentation favored the existence of a high S. cerevisiae strain diversity in organic wineries from Galicia. The presence of different yeasts during fermentation, specially winery-specific strains, contribute to increased wine complexity and differentiation.
COD19 and COD20: An Italian Experience of Active Home Surveillance in COVID-19 Patients
Authors: Zuccotti Gian Vincenzo , Bertoli Simona , Foppiani Andrea , Verduci Elvira , Battezzati Alberto
Published: September 2020

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic found Italy unprepared to cope with the large concentrated numbers of patients infected with coronavirus disease 2019 (COVID-19) who often required hospital admission and in many cases intensive care. This pandemic very quickly overwhelmed the Italian Healthcare System. This paper describes the Active Home Surveillance System (Operations Center for Discharged Patients; COD19) and the Home Hospital Care System (COD20) and presents the clinical data collected and the level of user satisfaction with the service. The Operations Center for Discharged Patients (COD19) is an active surveillance service for home-care patients which involves: (1) monitoring critical clinical conditions; (2) recognizing social and health issues; (3) and providing necessary clinical services in the form of a telemedicine service. COD20 is a patient-specialist video consultation service that allows to perform an assessment of clinical conditions and any need to visit; defining the priority of access to specialist outpatient visits in the presence or manageable with the new video consultation model. This service was immediately necessary during the COD19 monitoring. COD19 and COD20 are based on the Amazon Web Services Serverless certified platform. The COD19 and COD20 platform can be intrinsically utilized for future epidemic outbreaks; also those with non-respiratory transmission; and is sufficiently flexible to adapt to natural catastrophes.
Risk Factors of Metabolic Syndrome in Community-Dwelling People with Schizophrenia
Authors: Sun Min Jung , Jang Mi Heui
Published: September 2020

This study investigated the prevalence and risk factors of metabolic syndrome in 100 community-dwelling people with schizophrenia registered in mental health facilities in Seoul, Korea. This study was conducted between 12 September and 15 November 2019. This study used a cross-sectional descriptive design. The data included were general and disease-related characteristics, diagnostic tests for metabolic syndrome, lifestyles, depression, and social support. The analysis of collected data was done by using the SPSS 24.0 program. The prevalence of metabolic syndrome was 42.0%. Higher body mass index (odds ratio [OR] = 1.60, 95% CI = 1.16–2.18, p = 0.004), and depression (OR = 1.22, 95% CI = 1.06–1.42, p = 0.008) were associated with higher risks of metabolic syndrome, while physical activity and weight control (OR = 0.71, 95% CI = 0.54–0.94, p = 0.018), dietary habits (OR = 0.72, 95% CI = 0.54–0.93, p = 0.011), and medication and health management (OR = 0.52, 95% CI = 0.31–0.86, p = 0.012) were associated with lower risks. Mental health care nurses need to recognize the high prevalence of metabolic syndrome in people with schizophrenia in the community and provide differentiated, customized lifestyle improvement programs based on the body mass index and depression status of each person with schizophrenia. Furthermore, comprehensive lifestyle improvement programs and health examination services that people with schizophrenia can easily adhere to should be developed.
Perspectives and Practices on Water, Sanitation, and Hygiene from a Fishing Community along Lake Malombe, Southern Malawi
Authors: Kalumbi Limbani R. , Thaulo Chisomo , MacPherson Eleanor E. , Morse Tracy
Published: September 2020

People living in fishing communities have a high burden of preventable water, sanitation, and hygiene (WASH) related diseases but have often been neglected in research and policy. We explored practices and perspectives on WASH among fishing villages around Lake Malombe, Malawi. We employed a mixed methods design, and data were initially collected through participant observations (five weeks), followed by a second phase of qualitative interviews (n = 16), focus group discussions (n = 7), and quantitative surveys (n = 242). We observed that safe water sources were scarce; latrines were basic; and handwashing facilities were limited. Seventy-one percent (n = 174) of households collected water from unsafe sources (open wells and the lake). Eighty-six percent (n = 207) of households had basic short-term latrines. Twenty-four percent (n = 59) of households had handwashing facilities with soap. Qualitative data supported these observations and identified additional factors which compounded poor WASH practices including, a high transient population associated with the fishing trade, poor infrastructure design and construction which lacked consideration of the environmental factors, context and social and cultural norms. As such, fishing communities are underserved and marginalised with constrained access to WASH services, which must be addressed through behaviour-centered and context appropriate solutions.
Laterality in Children: Evidence for Task-Dependent Lateralization of Motor Functions
Authors: Bondi Danilo , Prete Giulia , Malatesta Gianluca , Robazza Claudio
Published: September 2020

The behavioral preference for the use of one side of the body starts from pre-natal life and prompt humans to develop motor asymmetries. The type of motor task completed influences those functional asymmetries. However, there is no real consensus on the occurrence of handedness during developmental ages. Therefore, we aimed to determine which motor asymmetries emerged differently during childhood. A total sample of 381 children in grades 1 to 5 (6–11 years old) of primary school were recruited and tested for two fine coordination tasks (Floppy, led by dexterity, and Thumb, led by speed-dominated skills) and handgrip strength (HS). Data about their handedness, footedness and sports participation were also collected. Children performed better with their dominant side, especially for the Floppy and HS tests. The asymmetries were more marked in right-handed children and did not differ by age, gender or type of sport. Our findings support the thesis of a functional lateralization in complex coordinative tasks and in maximal strength during developmental ages. Furthermore, our findings extend the evidence of a stronger lateralization in right-handed individuals, demonstrating it at a functional level in primary school children performing motor tasks. Fine motor skills allow a “fine” understanding of developmental trajectories of lateralized behavior.
Objective Facts or Misleading Hype? Associations between Features of E-Cigarette Marketing and Sales on a Chinese E-Commerce Platform
Authors: Chen Yibei , Sun Shaojing , Zhao Xiaoquan , Zhou Han , Wang Fan
Published: September 2020

Background: Electronic cigarettes (e-cigarettes) have been increasingly advertised and marketed in China in recent years. This study examined the practice and impact of e-cigarette online marketing on a major retail website—Tmall.com. Methods: Data were obtained by crawling 449 online pages of e-cigarette marketing. Content analysis was conducted to summarize the marketing practices for four types of e-cigarettes, and multilevel modeling (MLM) was implemented to explore factors predictive of the online sales of the products. Results: The sales volume of e-cigarettes ranged from 0 to 28,169, with the price per item varying from RMB 218.1 ($31.84) to RMB 385.5 ($56.29). Fruit (44.3%, n = 199), mint (33%, n = 148) and cream/sugar/ice (29.4%, n = 132) were the three flavors most often listed for sale online. Moreover, 63.4% (n = 285) of e-cigarette ads emphasized the role of the products as an aid to quit smoking. Nice taste (75.1%), big vapor (65.7%), high capacity batteries (67.9%), fashionable models (61.3%), discounted price (49.7%), and suitability for gifting (45.9%) were the most frequently touted product features in online ads. Type of e-cigarettes, diversity of products, number of online comments, and location of manufacturers were significantly associated with sales volume. Conclusions: Online marketing of e-cigarettes was common on one of China’s leading e-commerce websites. Sellers employed advertising strategies targeting a wide range of potential consumers—from youth to the elderly. Stricter regulations of online marketing for e-cigarettes should be enforced in China.
Job Stress, Burnout and Coping in Police Officers: Relationships and Psychometric Properties of the Organizational Police Stress Questionnaire
Authors: Queirós Cristina , Passos Fernando , Bártolo Ana , Faria Sara , Fonseca Sílvia Monteiro , Marques António José , Silva Carlos F. , Pereira Anabela
Published: September 2020

Policing is a stressful occupation, which impairs police officers’ physical/mental health and elicits burnout, aggressive behaviors and suicide. Resilience and coping facilitate the management of job stress policing, which can be operational or organizational. All these constructs are associated, and they must be assessed by instruments sensitive to policing idiosyncrasies. This study aims to identify operational and organizational stress, burnout, resilient coping and coping strategies among police officers, as well to analyze the psychometric properties of a Portuguese version of the Organizational Police Stress Questionnaire. A cross-sectional study, with online questionnaires, collected data of 1131 police officers. With principal components and confirmatory factor analysis, PSQ-org revealed adequate psychometric properties, despite the exclusion of four items, and revealed a structure with two factors (poor management and lack of resources, and responsibilities and burden). Considering cut-off points, 88.4% police officers presented high operational stress, 87.2% high organizational stress, 10.9% critical values for burnout and 53.8% low resilient coping, preferring task-orientated than emotion and avoidance coping. Some differences were found according to gender, age and job experience. Job stress and burnout correlated negatively with resilient coping, enthusiasm towards job and task-orientated coping. Results reinforce the importance to invest on police officers’ occupational health.
Red Blood Cells and Hemoglobin in Human Atherosclerosis and Related Arterial Diseases
Authors: Michel Jean-Baptiste , Martin-Ventura José Luis
Published: September 2020

As the main particulate component of the circulating blood, RBCs play major roles in physiological hemodynamics and impact all arterial wall pathologies. RBCs are the main determinant of blood viscosity, defining the frictional forces exerted by the blood on the arterial wall. This function is used in phylogeny and ontogeny of the cardiovascular (CV) system, allowing the acquisition of vasomotricity adapted to local metabolic demands, and systemic arterial pressure after birth. In pathology, RBCs collide with the arterial wall, inducing both local retention of their membranous lipids and local hemolysis, releasing heme-Fe++ with a high toxicity for arterial cells: endothelial and smooth muscle cells (SMCs) cardiomyocytes, neurons, etc. Specifically, overloading of cells by Fe++ promotes cell death. This local hemolysis is an event associated with early and advanced stages of human atherosclerosis. Similarly, the permanent renewal of mural RBC clotting is the major support of oxidation in abdominal aortic aneurysm. In parallel, calcifications promote intramural hemorrhages, and hemorrhages promote an osteoblastic phenotypic shift of arterial wall cells. Different plasma or tissue systems are able, at least in part, to limit this injury by acting at the different levels of this system.
Resveratrol Pretreatment Ameliorates Concanavalin A-Induced Advanced Renal Glomerulosclerosis in Aged Mice through Upregulation of Sirtuin 1-Mediated Klotho Expression
Authors: Chen Chin-Chang , Chang Zi-Yu , Tsai Fuu-Jen , Chen Shih-Yin
Published: September 2020

Aging kidneys are characterized by an increased vulnerability to glomerulosclerosis and a measurable decline in renal function. Evidence suggests that renal and systemic klotho and sirtuin 1 (SIRT1) deficiencies worsen kidney damage induced by exogenous stresses. The aim of this study was to explore whether resveratrol would attenuate concanavalin A (Con A)-induced renal oxidative stress and advanced glomerulosclerosis in aged mice. Aged male C57BL/6 mice were treated orally with resveratrol (30 mg/kg) seven times (12 h intervals) prior to the administration of a single tail-vein injection of Con A (20 mg/kg). The plasma and urinary levels of kidney damage markers were evaluated. The kidney histopathology, renal parameters, and oxidative stress levels were measured. Furthermore, klotho was downregulated in mouse kidney mesangial cells that were pretreated with 25 µM resveratrol followed by 20 µg/mL Con A. The urinary albumin/creatinine ratio, blood urea nitrogen, kidney mesangial matrix expansion, tubulointerstitial fibrosis, and renal levels of α-smooth muscle actin, transforming growth factor beta, fibronectin, procollagen III propeptide, and collagen type I significantly increased in Con A-treated aged mice. Aged mice kidneys also showed markedly increased levels of 8-hydroxydeoxyguanosine (8-OH-dG) and reactive oxygen species (ROS), with reduced superoxide dismutase activity and levels of glutathione, klotho, and SIRT1 after Con A challenge. Furthermore, in kidney mesangial cells, klotho silencing abolished the effects of resveratrol on the Con A-mediated elevation of the indices of oxidative stress and the expression of glomerulosclerosis-related factors. These findings suggest that resveratrol protects against Con A-induced advanced glomerulosclerosis in aged mice, ameliorating renal oxidative stress via the SIRT1-mediated klotho expression.
Extracellular Vesicles in the Tumour Microenvironment: Eclectic Supervisors
Authors: Cavallari Claudia , Camussi Giovanni , Brizzi Maria Felice
Published: September 2020

The tumour microenvironment (TME) plays a crucial role in the regulation of cell survival and growth by providing inhibitory or stimulatory signals. Extracellular vesicles (EV) represent one of the most relevant cell-to-cell communication mechanism among cells within the TME. Moreover, EV contribute to the crosstalk among cancerous, immune, endothelial, and stromal cells to establish TME diversity. EV contain proteins, mRNAs and miRNAs, which can be locally delivered in the TME and/or transferred to remote sites to dictate tumour behaviour. EV in the TME impact on cancer cell proliferation, invasion, metastasis, immune-escape, pre-metastatic niche formation and the stimulation of angiogenesis. Moreover, EV can boost or inhibit tumours depending on the TME conditions and their cell of origin. Therefore, to move towards the identification of new targets and the development of a novel generation of EV-based targeting approaches to gain insight into EV mechanism of action in the TME would be of particular relevance. The aim here is to provide an overview of the current knowledge of EV released from different TME cellular components and their role in driving TME diversity. Moreover, recent proposed engineering approaches to targeting cells in the TME via EV are discussed.
The Effects of Major Selection Motivations on Dropout, Academic Achievement and Major Satisfactions of College Students Majoring in Foodservice and Culinary Arts
Authors: Kim Jung Soo
Published: September 2020

This study is aimed at figuring out the effects of major selecting motivation on dropout, academic achievement, and major satisfactions of college students majoring in foodservice and culinary arts. To accomplish this, an empirical survey was conducted through a structural equation model. These findings showed that students are likely to drop out of college due to a career change or major maladjustment if they decide their major in consideration of college reputation or department recognition rather than their aptitude. Unlike existing studies, this study has practical implications concerning the importance of these factors in that their academic achievement is affected by their relationship and perception of their major satisfactions rather than their major selection motivations.
Discrete Time Ruin Probability for Takaful (Islamic Insurance) with Investment and Qard-Hasan (Benevolent Loan) Activities
Authors: Puspita Dila , Kolkiewicz Adam , Tan Ken Seng
Published: September 2020

The main objectives of this paper are to construct a new risk model for modelling the Hybrid-Takaful (Islamic Insurance) and to develop a computational procedure for calculating the associated ruin probability. Ruin probability is an important study in actuarial science to measure the level of solvency adequacy of an insurance product. The Hybrid-Takaful business model applies a Wakalah (agent based) contract for underwriting activities and Mudharabah (profit sharing) contract for investment activities. We consider the existence of qard-hasan facility provided by the operator (shareholder) as a benevolent loan for the participants’ fund in case of a deficit. This facility is a no-interest loan that will be repaid if the business generates profit in the future. For better investment management, we propose a separate investment account of the participants’ fund. We implement several numerical examples to analyze the impact of some key variables on the Takaful business model. We also find that our proposed Takaful model has a better performance than the conventional counterpart in terms of the probability of ruin.
Laser-Assisted Synthesis of Composite Nanoparticles of Perovskite BaTiO3 in Aqueous Solutions and Their Optical Properties
Authors: Barmina Ekaterina V. , Mukhametyanov Bulat A. , Uvarov Oleg V. , Vlasov Igor I. , Kudryavtsev Oleg S. , Kalachev Yurii L. , Skoulas Evangelos , Kourmoulakis George , Voronov Valeriy V. , Stratakis Emmanuel , Shafeev Georgy A.
Published: September 2020

Experimental results are presented on laser-assisted synthesis of composite nanoparticles of perovskite BaTiO3 with gold nanoparticles using the technique of laser ablation in water and aqueous solution of hydrogen peroxide. Nanoparticles of BaTiO3 are generated by near IR laser radiation with pulse durations of 170 fs, 1 ps, and 200 ns. Nanoparticles of barium titanate BaTiO3 (BTO) have tetragonal structure for all used pulse durations. Two ways of synthesis are tested. In the first one a gold target is ablated in the colloidal solution of BaTiO3 nanoparticles. The second way consists of laser exposure of the mixture of colloidal solutions of nanoparticles of BaTiO3 and Au. Synthesized composite nanoparticles are characterized by optical spectroscopy, Raman spectroscopy, X-Ray diffractometry, and Transmission Electron Microscopy. Composite BaTiO3‑Au nanoparticles have the absorption band in the visible range of spectrum and demonstrate plasmonic luminescence.
The Influence of Heat Treatment Temperature on Microstructures and Mechanical Properties of Titanium Alloy Fabricated by Laser Melting Deposition
Authors: Wang Wei , Xu Xiaowen , Ma Ruixin , Xu Guojian , Liu Weijun , Xing Fei
Published: September 2020

Ti-6Al-4V (TC4) titanium alloy parts were successfully fabricated by laser melting deposition (LMD) technology in this study. Proper normalizing temperatures were presented in detailed for bulk LMD specimens. Optical microscope, scanning electron microscopy, X-ray diffraction, and electronic universal testing machine were used to characterize the microstructures, phase compositions, the tensile properties and hardness of the TC4 alloy parts treated using different normalizing temperature. The experimental results showed that the as-fabricated LMD specimens’ microstructures mainly consisted of α-Ti phase with a small amount of β-Ti phase. After normalizing treatment, in the area of α-Ti phase, the recrystallized length and width of α-Ti phase both increased. When normalizing in the (α + β) phase field, the elongated primary α-Ti phase in the as-deposited state was truncated due to the precipitation of β-Ti phase and became a short rod-like primary α-Ti phase. In as-fabricated microstructure, the β-Ti phase was precipitated between different short rod-shaped α-Ti phases distributed as basketweave. After normalizing treatment at 990 for two hours with subsequent air cooling, the TC4 titanium alloy had significant different microstructures from original sample produced by LMD. The normalizing treatment methods and temperature can be qualified as a prospective heat treatment of titanium alloy fabricating by laser melting deposition.
Changes in Child and Adult Care Food Program (CACFP) Practices at Participating Childcare and Education Centers in the United States Following Updated National Standards, 2017–2019
Authors: Chriqui Jamie F. , Leider Julien , Schermbeck Rebecca M. , Sanghera Anmol , Pugach Oksana
Published: September 2020

The U.S. Department of Agriculture’s (USDA) Child and Adult Care Food Program (CACFP) updated meal pattern standards took effect in October 2017. The aim of this quasi-experimental, pre-post study is to identify changes in food and beverage practices of CACFP-participating centers due to implementation of updated CACFP meal patterns over a 21-month period. Eight hundred and fifty-eight centers located in 47 states and the District of Columbia completed a survey (primarily electronic) at both time points (67.6% follow-up response rate). Multivariable logistic regressions with robust standard errors assessed changes over time, accounting for repeated observations within each site. From baseline to follow-up, centers reported the increased familiarity and implementation, albeit with time, money, and staffing-related challenges. Significant improvements were seen in not serving sugary cereals or flavored milk, in serving 100% whole grains, and serving processed meats less than once a week. While CACFP-participating centers reported making significant progress in meeting the updated meal pattern standards and suggested best practices within 15–19 months of their effective date, reported compliance and adherence to the standards and best practices was not universal. USDA, state agencies, and technical assistance providers should work to provide centers with additional guidance to help them with implementation.
Eating Habits and Physical Activity of the Spanish Population during the COVID-19 Pandemic Period
Authors: Sánchez-Sánchez Eduardo , Ramírez-Vargas Guillermo , Avellaneda-López Ylenia , Orellana-Pecino J. Ignacio , García-Marín Esperanza , Díaz-Jimenez Jara
Published: September 2020

Due to the pandemic situation caused by the COVID-19 infection, some governments have implemented house confinement measures. The objective of our study is to learn the dietary patterns, consumption, and physical activity of the Spanish population before and during the period of confinement by COVID-19. A cross-sectional descriptive study based on a questionnaire during May 2020, coinciding with the period of confinement and the step forward into Phase 1, is carried out. During confinement, the adherence to the Mediterranean Diet increases (8.0% versus 4.7%; p < 0.001). No socio-demographic variables show statistical significance (p < 0.05) regarding good adherence to the Mediterranean Diet (MD) before and during confinement. During confinement, consumption of homemade baking shows a higher increase (0.28% versus 4.60%; p = 0.004). During confinement, the number of subjects that practice exercise decreases (29.4% versus 28.8%; p = 0.004), as well as the time spent exercising (more than an hour, 26.6% versus 14.7%, p = 0.001). Mediterranean Diet adherence slightly increases during confinement, although consumption of ‘unhealthy’ food also increases. Moreover, the number of subjects that practice physical activity, as well as the time spent on it weekly, decreases.
The Interband Cascade Laser
Authors: Meyer Jerry , Bewley William , Canedy Chadwick , Kim Chul , Kim Mijin , Merritt Charles , Vurgaftman Igor
Published: September 2020

We review the history, development, design principles, experimental operating characteristics, and specialized architectures of interband cascade lasers for the mid-wave infrared spectral region. We discuss the present understanding of the mechanisms limiting the ICL performance and provide a perspective on the potential for future improvements. Such device properties as the threshold current and power densities, continuous-wave output power, and wall-plug efficiency are compared with those of the quantum cascade laser. Newer device classes such as ICL frequency combs, interband cascade vertical-cavity surface-emitting lasers, interband cascade LEDs, interband cascade detectors, and integrated ICLs are reviewed for the first time.
Variable Light Condition Improves Root Distribution Shallowness and P Uptake of Soybean in Maize/Soybean Relay Strip Intercropping System
Authors: Wang Li , Zhou Tao , Cheng Bin , Du Yongli , Qin Sisi , Gao Yang , Xu Mei , Lu Junji , Liu Ting , Li Shuxian , Liu Weiguo , Yang Wenyu
Published: September 2020

In this study, soybean root distribution in an inter-cropping system was influenced by various environmental and biotic cues. However, it is still unknown how root development and distribution in inter-cropping responds to aboveground light conditions. Herein, soybeans were inter- and monocropped with P (phosphorus) treatments of 0 and 20 kg P ha yr−1 (P0 and P20, respectively) in field experiment over 4 years. In 2019, a pot experiment was conducted as the supplement to the field experiment. Shade from sowing to V5 (Five trifoliolates unroll) and light (SL) was used to imitate the light condition of soybeans in a relay trip inter-cropping system, while light then shade from V5 to maturity (LS) was used to imitate the light condition of soybeans when monocropped. Compared to monocropping, P uptake and root distribution in the upper 0–15 cm soil layer increased when inter-cropped. Inter-cropped soybeans suffered serious shade by maize during a common-growth period, which resulted in the inhibition of primary root growth and a modified auxin synthesis center and response. During the solo-existing period, plant photosynthetic capacity and sucrose accumulation increased under ameliorated light in SL (shade-light). Increased light during the reproductive stage significantly decreased leaf P concentration in SL under both P-sufficient and P-deficient conditions. Transcripts of a P starvation response gene (GmPHR25) in leaves and genes (GmEXPB2) involved in root growth were upregulated by ameliorated light during the reproductive stage. Furthermore, during the reproductive stage, more light interception increased the auxin concentration and expression of GmYUCCA14 (encoding the auxin synthesis) and GmTIR1C (auxin receptor) in roots. Across the field and pot experiments, increased lateral root growth and shallower root distribution were associated with inhibited primary root growth during the seedling stage and ameliorated light conditions in the reproductive stage. Consequently, this improved topsoil foraging and P uptake of inter-cropped soybeans. It is suggested that the various light conditions (shade-light) mediating leaf P status and sucrose transport can regulate auxin synthesis and respond to root formation and distribution.
Graphene and Polyethylene: A Strong Combination Towards Multifunctional Nanocomposites
Authors: López-González Mar , Flores Araceli , Marra Fabrizio , Ellis Gary , Gómez-Fatou Marián , J. Salavagione Horacio
Published: September 2020

The key to the preparation of polymer nanocomposites with new or improved properties resides in the homogeneous dispersion of the filler and in the efficient load transfer between components through strong filler/polymer interfacial interactions. This paper reports on the preparation of a series of nanocomposites of graphene and a polyolefin using different experimental approaches, with the final goal of obtaining multifunctional materials. A high-density polyethylene (HDPE) is employed as the matrix, while unmodified and chemically modified graphene fillers are used. By selecting the correct combination as well as the adequate preparation process, the nanocomposites display optimized thermal and mechanical properties, while also conferring good gas barrier properties and significant levels of electrical conductivity.
Causes of the Gloss Transition Defect on High-Gloss Injection-Molded Surfaces
Authors: Gim Jinsu , Han Eunsu , Rhee Byungohk , Friesenbichler Walter , Gruber Dieter P.
Published: September 2020

The gloss transition defect of injection-molded surfaces should be mitigated because it creates a poor impression of product quality. Conventional approaches for the suppression of the gloss transition defect employ a trial-and-error approach and additional equipment. The causes of the generation of a low-gloss polymer surface and the surface change during the molding process have not been systematically analyzed. This article proposes the causes of the generation of a low-gloss polymer surface and the occurrence of gloss transition according to the molding condition. The changes in the polymer surface and gloss were analyzed using gloss and topography measurements. The shrinkage of the polymer surface generates a rough topography and low glossiness. Replication to the smooth mold surface compensates for the effect of surface shrinkage and increases the surface gloss. The surface stiffness and melt pressure influence the degree of mold surface replication. The flow front speed and mold temperature are the main factors influencing the surface gloss because they affect the development rate of the melt pressure and the recovery rate of the surface stiffness. Therefore, the mold design and process condition should be optimized to enhance the uniformity of the flow front speed and mold temperature.
Integrated Geological and Geophysical Mapping of a Carbonatite-Hosting Outcrop in Siilinjärvi, Finland, Using Unmanned Aerial Systems
Authors: Jackisch Robert , Lorenz Sandra , Kirsch Moritz , Zimmermann Robert , Tusa Laura , Pirttijärvi Markku , Saartenoja Ari , Ugalde Hernan , Madriz Yuleika , Savolainen Mikko , Gloaguen Richard
Published: September 2020

Mapping geological outcrops is a crucial part of mineral exploration, mine planning and ore extraction. With the advent of unmanned aerial systems (UASs) for rapid spatial and spectral mapping, opportunities arise in fields where traditional ground-based approaches are established and trusted, but fail to cover sufficient area or compromise personal safety. Multi-sensor UAS are a technology that change geoscientific research, but they are still not routinely used for geological mapping in exploration and mining due to lack of trust in their added value and missing expertise and guidance in the selection and combination of drones and sensors. To address these limitations and highlight the potential of using UAS in exploration settings, we present an UAS multi-sensor mapping approach based on the integration of drone-borne photography, multi- and hyperspectral imaging and magnetics. Data are processed with conventional methods as well as innovative machine learning algorithms and validated by geological field mapping, yielding a comprehensive and geologically interpretable product. As a case study, we chose the northern extension of the Siilinjärvi apatite mine in Finland, in a brownfield exploration setting with plenty of ground truth data available and a survey area that is partly covered by vegetation. We conducted rapid UAS surveys from which we created a multi-layered data set to investigate properties of the ore-bearing carbonatite-glimmerite body. Our resulting geologic map discriminates between the principal lithologic units and distinguishes ore-bearing from waste rocks. Structural orientations and lithological units are deduced based on high-resolution, hyperspectral image-enhanced point clouds. UAS-based magnetic data allow an insight into their subsurface geometry through modeling based on magnetic interpretation. We validate our results via ground survey including rock specimen sampling, geochemical and mineralogical analysis and spectroscopic point measurements. We are convinced that the presented non-invasive, data-driven mapping approach can complement traditional workflows in mineral exploration as a flexible tool. Mapping products based on UAS data increase efficiency and maximize safety of the resource extraction process, and reduce expenses and incidental wastes.