bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Hybrid Feature Extraction Methods for EEG Based Emotions Classification Using Ensemble Approaches in HIED Dataset
Authors: A Stephen Dass , J Prabhu
Published: July 2024

Introduction:

Emotions play a significant role in human relationships in everyday
challenges. Human-machine interactions and the complexities of its research include humanoid
robots which rely significantly on emotional queries. The present study recommends a novel
methodology for human emotion identification using electroencephalogram (EEG) signals.
Machine learning (ML) techniques based on electroencephalogram have demonstrated impressive
results in distinguishing emotions.

Method:

The present study investigates five ensemble learning-based machine learning
(EML) and five conventional machine learning (CML) algorithms for achieving the recognition
of human emotions from EEG signals. The main objective of the current research study is to
implement the optimal approach for classifying emotions and subsequently will achieve it by
using physiological characteristics to categorise the seven main emotional states (stress, happy,
sadness, anger, fear, disgust, and surprise). This research follows the study investigation of
ensemble learning-based machine learning (EML) and conventional machine learning (CML)
algorithms for achieving the recognition of human emotions from EEG signals. Initially, the
EEG data in this study are categorized into theta, alpha, beta, and gamma bands using a DWT.

Result:

With this idea, the research elaborates on further decomposition based on bandseparated
EEG signals known as intrinsic mode functions (IMFs) along with empirical mode
decomposition is subsequently implemented. Then, 13 statistical characteristics are extracted
from the IMFs using five multiclass EML algorithms: adaptive boosting, rotation random forest,
bagging, random forest, and extreme gradient boost. The following procedure is carried out
to construct an ML-based system. In the final phase, 10-fold cross-validation is used to assess
the efficacy of these five EML algorithms. Accuracy, F1-score, and area-under-the-curve
(AUC) are performance assessment metrics that are employed to compare the final results of
these algorithms with the five CML techniques.

Conclusion:

The proposed method for EEG-based emotion analysis is significantly more effective
and achieves greater outcomes than all of the techniques that were compared, based on
the data from the experiments.
GaN-Based Integrated Optical Devices for WideScenario Sensing Applications
Authors: An Xiaoshuai , Li Kwai Hei
Published: July 2024

Sensors that detect variations in the surroundings and convert them into
electrical signals are crucial in numerous fields, including healthcare, manufacturing,
and environmental monitoring. Optical sensors, in terms of various sensing principles,
hold considerable potential due to their fast response, high sensing resolution, and
ability to withstand magnetic interference. Despite their advantages, traditional optical
sensing techniques also have certain limitations, such as bulky structures, tedious
alignment procedures, and high production expenses. To address this issue, on-chip
integration has been proposed, and GaN and its alloys can be ideal materials due to
their high efficiency, long lifespan, and high stability. By simultaneously forming the
light emitter and photodetector on a shared substrate through wafer-fabrication
processes, miniaturized GaN optical sensors possess a compact design, small size, high
robustness, low manufacturing cost, and simple operations. This chapter discusses the
working mechanisms and influencing factors of integrated GaN devices alongside their
recent progress in advanced sensing applications.
SiGe Source-Based Epitaxial Layer-Encapsulated TFET and its Application as a Resistive Load Inverter
Authors: Debnath Radhe Gobinda , Baishya Srimanta
Published: July 2024

In this study, a SiGe source-based epitaxial layer-encapsulated TFET (SiGe
source ETLTFET) is developed, and the performance of the device is examined by
optimizing various design parameters, including the epitaxial layer thickness (tepi), gateto-source overlap length (Lov), Ge mole fraction, and source doping concentration. The
average subthreshold swing (SSavg) and ON-OFF current ratio are used to evaluate the
device’s performance. The results show a superior performance of SiGe source
ETLTFET compared with its homojunction counterpart. Furthermore, to demonstrate
the possibilities for using the proposed device in a logic circuit, a resistive load inverter
is designed using the n-type ETLTFET.
A Case Study on Bala Amavata w.s.r. to Juvenile Rheumatoid Arthritis
Authors: Akshay A. Gurav  , Shailaja U
Published: July 2024

Introduction: Amavata is one of the most difficult to cure (Krichhrasadhya) diseases mentioned in Ayurveda. The main pathological factor in the development of this disease is “Ama”. This Ama is carried by “Vata” and travels throughout the body and gets lodges in the joints, which is the seat of “Kapha”. Accumulation of Ama in all the joints, results in Shotha (edema), Shoola (pain) and Stabdhata (stiffness) in the joints. Clinically, it is closely related to Rheumatoid Arthritis, which is a chronic inflammatory autoimmune disease involving multiple joints of the body. Methodology: A 13years boy with multiple joint pain, diagnosed as Amavata treated with Ayurvedic treatment modalities like Patrapinda Sweda and Virechana. Result: Remarkable improvement was noticed in pain, swelling, morning stiffness and restricted joint movement within first two months. Discussion: In modern medicine, the treatment of this disease includes steroids and Immunomodulator drugs together with non-steroidal anti-inflammatory drugs (NSAIDs), which acts as only Symptomatic treatment, whereas Virechana karma is one of the important bio-purificative methods which is indicated for complete elimination of Dushita Doshas and Ama from the body. Hence this article highlights on the importance of Ayurvedic treatment in the management of Amavata (Rheumatoid Arthritis).
Disability Justice and Libraries: An Indonesian Experience
Authors: Atha Difa Saputri ,   Universitas Negeri Semarang, Ridwan Arifin ,   Universitas Negeri Semarang
Published: July 2024

This research explores the intersection of disability justice and library services in Indonesia. The study investigates the challenges faced by individuals with disabilities in accessing library resources and services and examines the initiatives taken by Indonesian libraries to promote inclusivity and equity. This research involves a qualitative analysis of the experiences of library users with disabilities, as well as interviews with library staff and administrators. It highlights the importance of designing libraries and services that accommodate diverse needs and abilities. The study also discusses the role of technology, adaptive equipment, and staff training in creating accessible library environments. The findings shed light on the progress made in advancing disability justice within the Indonesian library community and offer insights into the remaining barriers and opportunities for improvement. By sharing these experiences and strategies, this study contributes to the global discourse on disability justice and libraries, aiming to inspire positive change and greater inclusivity in library services worldwide.
Engaging the Digital Native Generation in Cultural Digital Preservation: Strategies and Approaches for Libraries and Librarians in the Digital Age 4.0
Authors: Gabriel Wahyu Purnomo ,   Universitas Brawijaya, Kurniasih Yuni Pratiwi ,   Universitas Brawijaya
Published: July 2024

Digital cultural preservation is becoming increasingly important in the digital 4.0 era, where the digital native generation has a central role in the use of digital technology. Libraries and librarians as custodians of knowledge and culture must engage the digital native generation in cultural digital preservation efforts. However, effective strategies and approaches need to be developed to ensure their active participation in this preservation. This study takes a qualitative approach to data collection, including in-depth interviews and a literature review. Data analysis was conducted using thematic techniques to identify strategies and approaches used in engaging the digital native generation. This study found that, several strategies and approaches were found to be effective in engaging the digital native generation in cultural digital preservation. Firstly, libraries should provide easy and intuitive access to cultural digital resources for the digital native generation. Second, a collaborative and participatory approach involves them in the process of curating and determining the direction of cultural digital preservation. Third, training and educational programs should be organized to improve digital literacy and understanding of the importance of digital cultural preservation. This study concluded that engaging digital native in digital cultural preservation requires a holistic and multifaceted approach. Libraries and librarians need to adopt strategies that are responsive to the needs and preferences of digital native. In the digital era 4.0, digital cultural preservation is not just a task for libraries, but a shared responsibility to ensure the sustainability and accessibility of digital cultural heritage for current and future generations.
Digital Preservation and Mitigation of Cultural Heritage
Authors: Cuikitalia Cuikitalia ,   Brawijaya University
Published: July 2024

Digital preservation is an important process to maintain the authenticity of cultural heritage sites that are threatened by infrastructure development. Many cultural heritage sites have just been discovered recently and preservation is required to preserve them. The rapid development of infrastructure can threaten the existence of cultural heritage sites in the area. The aim of this research is that digital preservation is an effective solution for maintaining the authenticity of cultural heritage sites and facilitating access to information in the future. In the context of agrarian law, there is a question about how the law views which is more important, the preservation of cultural heritage sites or the community's need for infrastructure. This study used a qualitative research method with a case study approach at the “Sekaran Site”, Lesanpuro which was affected by the construction of the Pakis toll road exit, Malang. Interviews were conducted with residents as well as analysis and documents available in the findings of the Sekaran cultural heritage site. The results of the study indicate that the use of digital technology and the development of digital platforms can assist in maintaining and communicating information about the Sekaran cultural heritage site. Digital preservation can also increase public awareness about the importance of preserving cultural heritage and can be an effective tool in overcoming the impact of infrastructure development on cultural heritage sites. In the case of the Sekaran Site, the Government is preserving the site by turning up to 17.5 meters from the starting point of the construction of the Malang Pandaan Toll Road. This was done after the discovery of piles of bricks arranged to resemble a building. In this case, digital preservation can assist in identifying threatened cultural heritage sites and facilitating the preservation process.
Strengthening Accessibility and Inclusivity in Libraries: The Role of Adaptive Technology in Supporting Visually Impaired Users
Authors: Gabriel Wahyu Purnomo ,   Universitas Brawijaya, Prayoga Rizki Wikandani ,   Universitas Brawijaya
Published: July 2024

Libraries have long been recognized as key institutions in democratizing access to knowledge and information, yet users with visual impairments still face significant barriers to accessing these resources. The purpose of this research is to explore how adaptive technologies can improve accessibility and inclusivity in libraries for users with visual impairments. Using a qualitative methodology involving in-depth interviews and content analysis of library websites, this study assessed the effectiveness of current adaptive technologies and identified barriers to their use. The results show that, although adaptive technologies such as screen readers and indoor navigation systems hold great potential to improve user experience, there are still gaps in implementation and library staff awareness of the specific needs of visually impaired users. The conclusions of this study emphasize the importance of holistic integration of adaptive technologies in library service strategies to ensure equal access. Based on these findings, this paper recommends better staff training, the development of strong inclusive policies, and collaboration with disabled people's organizations to improve the accessibility and inclusiveness of libraries, thus supporting wider social participation of visually impaired users.
Efektivitas Rifapentine Pada Pasien Dewasa Dengan Infeksi TuberkulosisLaten (ITBL): Sebuah Kajian Sistematis
Authors: Annisa Sandra ,   Puskesmas Loa Bakung Samarinda, Dinas Kesehatan Kota Samarinda, Indonesia, Herawati Fauna ,   Departemen Farmasi Klinis dan Komunitas, Fakultas Farmasi, Universitas Surabaya, Indonesia
Published: July 2024

Tuberculosis (TB) is an infectious disease whose successful treatment in Indonesia is affected by malnutrition, smoking, diabetes mellitus, and HIV infection. People with good immunity can prevent developing active disease, but the bacteria persistent in a dormant state. It will be active tuberculosis whenever (in few months) the immune system unable controlling the growth of TB bacteria. This systematic review aims to examine the effectiveness of rifapentine and its use with other regimens in patients with latent tuberculosis infection (LTBI). This study included literature published in the PubMed database from early January 2011 to January 2021, with keywords: "Effectiveness Rifapentine", “Tuberculosis”, and the Boolean operators, "AND". This study reported that there wew seventheen in studies countries, none in Indonesia. This study come to end that a regiment therapy with a combination of Rifapentine (P) and Isoniazid (H) once-weekly dose (called 3HP) for three months shows a good efficacy in LTBI patients, can improve patient adherence because of a shorter regiment administration and reduce the hepatotoxicity risk in patients with a history of chronic liver disease or increased aspartate transaminase (AST) level.
Pengembangan Modul Pembelajaran Mata Pelajaran Pengecatan Bodi Pada SMK Program Keahlian Teknik Bodi Otomotif
Authors: Ryandika Aldian , Rabiman Rabiman , Purnomo Sigit
Published: July 2024

This research is a development research (research and development) with the development of learning media in the form of Automotive Body Engineering modules in Class XI Body Painting Subjects at SMK Kristen 5 Klaten using the Four-D method by Thiagarajan and Semmel which has been modified. The stages used in the module development process are the defining stage (define), the design stage (design), the development stage (develop) and the dissemination stage (disseminate). Collecting feasibility data using questionnaires and observations. This study involved material experts, media experts, subject teachers and students to obtain module feasibility assessments and responses. The data analysis technique used was quantitative descriptive analysis.The results showed that: 1) produce an Automotive Body Engineering learning module; 2) the Automotive Body Engineering learning module at SMK Kristen 5 Klaten is feasible to use based on the results of material expert validation with a percentage of 76.08% and the results of validation by media experts with a percentage of 73.80% with a decent category; The results of the assessment of the feasibility level of the Automotive Body Engineering learning module at SMK Kristen 5 Klaten by the subject teacher with a percentage of 88.23% with a decent category; 4) The results of the assessment response from class XI students were 94.14% with a very feasible category.
Karakteristik Panas pada Exhaust manifold dengan Variasi Putaran Mesin menggunakan Computational Fluid Dynamics
Authors: Wakid Muhkamad , Widyianto Agus , Widowati Asri
Published: July 2024

Pemanfaatan teknologi dalam industri otomotif telah memberikan dampak signifikan terhadap efisiensi mesin kendaraan. Salah satu aspek kritis dalam sistem pembakaran adalah manajemen panas pada exhaust manifold. Penelitian ini bertujuan untuk mengkarakteristikkan distribusi panas, tekanan dan kecepatan aliran gas buang pada exhaust manifolddengan variasi putaran mesin menggunakan Computational Fluid Dynamics (CFD). Dalam penelitian ini menggunakan empat variasi putaran mesin yaitu 750 rpm, 1000 rpm, 1500 rpm dan 2000 rpm. Setiap variasi putaran mesin memiliki suhu serta kecepatan aliran gas buang yang berbeda pada setiap saluran masuknya. Putaran mesin 750 rpm menaikkan suhu material manifold buang hingga 235°C. Suhu permukaan material meningkat secara signifikan seiring dengan kecepatan mesin. Perbandingan antara profil suhu gas buang dan suhu permukaan bahan exhaust manifoldmengungkapkan hubungan erat antara aktivitas mesin dan suhu permukaan. Peningkatan suhu seiring dengan kenaikan putaran mesin mencerminkan intensifikasi aktivitas pembakaran, memiliki dampak langsung pada kestabilan suhu manifold. Analisis tekanan gas buang menyoroti peningkatan tekanan seiring dengan peningkatan putaran mesin. Lonjakan tekanan pada putaran mesin tinggi mengindikasikan intensifikasi dalam volume dan kecepatan aliran gas buang selama fase pembakaran. Profil kecepatan aliran gas buang menunjukkan peningkatan sejalan dengan pertambahan putaran mesin.
Mempercepat Proses Melepas dan Memasang Paku Rivet Dengan SST Press Pada Brake Lining Pad di Isuzu Sales Operation Harapan Indah
Authors: Nugraha Afitro Adam , Zulfikar Farhan Aufa , Waluyo Teguh , Widyartono Andreas Edi , Purwoko Pembabtis Agung
Published: July 2024

The process of removing and installing rivets when replacing the brake lining pad takes a long time. This process takes a long time because technicians still use manual methods, namely chisels and hammers. This research aims to reduce the time in this process by creating special service tools (SST). The method used is making 2D, and 3D designs, and stress analysis to determine the size and durability of the SST using Inventor 2023 software. Next, make an SST prototype and standard operating procedures (SOP) for how to use the SST Press Nail Rivet as a new procedure for removing and installing the rivets on the brake lining pad. This research was able to speed up the previously 8 hours 36 minutes, the workshop target was 7 hours 55 minutes. But the actual condition is 6 hours 50 minutes. Thus reducing lead time by 20% from the initial time. With the SST Press Rivet Nails on the Brake Lining Pad, the job of removing and installing rivets during the brake lining replacement process becomes faster and safer.Pada proses pelepasan dan pemasangan paku rivet pada pergantian brake lining pad membutuhkan waktu yang lama. Lamanya proses tersebut dikarenakan teknisi masih menggunakan cara manual, yaitu dengan pahat dan palu. Penelitian ini bertujuan untuk mengurangi waktu pada proses tersebut dengan membuat special service tools (SST). Metode yang digunakan yaitu pembuatan desain 2D,3D, dan analysis stress untuk menentukan ukuran serta ketahanan dari SST dengan menggunakan software inventor 2023. Selanjutnya membuat prototyipe SST dan standar operasional prosedur (SOP) untuk cara penggunaan dari SST Press Paku Rivet sebagai prosedur baru dalam melepas dan memasang paku rivet pada brake lining pad. Pada penelitian ini mampu mempercepat yang tadinya 8 jam 36 menit, target bengkel adalah 7 jam 55 menit. Tetapi kondisi aktualnya adalah 6 jam 50 menit. Sehingga menurunkan lead time sebesar 20% dari waktu awal. Dengan adanya SST Press Paku Rivet Pada Brake Lining Pad pekerjaan melepas dan memasang paku rivet pada proses pergantian brake lining menjadi lebih cepat dan aman.
Pengembangan Media Pembelajaran Video Tutorial Gambar Teknik di SMK
Authors: Syahputra Mario Dwi , Setuju Setuju
Published: July 2024

AbstrakDengan menggunakan metode pengembangan penelitian dan pendekatan RD dengan model ADDIE, saya yakin pengembangan media pembelajaran yang interaktif dan menarik akan meningkatkan pemahaman dan minat siswa dalam mempelajari materi gambar teknik. Selanjutnya saya berharap media pembelajaran yang saya kembangkan dapat memberikan dampak positif dalam meningkatkan kualitas pembelajaran gambar teknik di SMK. Hasil penelitian dari media Microsoft PowerPoint yang saya kembangkan terlebih dahulu saya desain materinya dalam Microsoft PowerPoint dan setelah itu saya membuat video tutorial gambar teknik disertai dengan soal evaluasi untuk siswa. Untuk kelayakan media pembelajaran Microsoft PowerPoint beserta video tutorial gambar teknik. sangat membantu proses pembelajaran mendeskripsikan gambar teknik dan siswa mampu menguasai materi.Kata Kunci: Pengembangan, Gambar Teknik, Media Pembelajaran AbstrakDengan menggunakan metode penelitian pengembangan dan pendekatan RD dengan model ADDIE saya yakin bahwa pengembangan media pembelajaran yang interaktif dan menarik akan meningkatkan pemahaman dan minat belajar siswa terhadap materi gambar teknik. Lebih lanjut, saya berharap bahwa media pembelajaran yang saya kembangkan akan memberikan dampak positif dalam meningkatkan kualitas pembelajaran gambar teknik di SMK. hasil penelitian dari media microsoft powerpoint yang saya kembangkan pertama saya mendesain materi di microsof powerpoint dan setelah itu saya membuat video tutorial gambar Teknik diserti pertanyaan evaluasi terhadap siswa. Untik kelayakan media pembelajaran microsoft powerpoint beserta video tutorial gambar Teknik. sangat membantu proses pembelajaran mendeskripsikan gambar Teknik dan siswa mampu menguasai materi tersebut.Kata Kunci : Pengembangan, video tutorial, Gambar Teknik, Media Pembelajaran
Surface microstructuring of hot-rolled carbon structural steels under complex exposure to laser radiation
Authors: Minaev I. V. , Kutepov S. N. , Klementyev D. S. , Zhurba D. V. , Golyshev I. V.
Published: July 2024

The purpose of the work was to study the effect of laser microstructuring modes of the cutting edge on changes in the structure and mechanical properties of the surface layer of parts made of hot-rolled structural carbon steels grades 20, 35, 45.

   Methods. Structural carbon steels of grades 20, 35, 45 were selected as objects of research. To study the effect of laser modification on changing the structure and mechanical properties of machine parts using laser cutting, special samples were made in the form of square plates (35×35 mm) with a thickness of 2 mm (St20 and St45) and 4 mm (St35). After laser cutting according to the modes, one of the sides of the sample was subjected to mechanical grinding in order to remove a layer with a modified structure of the material obtained during laser cutting. Next, laser microstructuring of the sample surfaces was performed using a continuous fiber laser. Metallographic and durometric studies were carried out to study the effect of laser microstructuring on changes in the structure and properties of the surface layer.

   Results. The regularities of the structure of the zone of laser action of structural carbon steels after laser microstructuring have been revealed, which consists of two layers: a non-etching (slightly etching) white layer, which is a finely dispersed martensite of a needle structure and immediately following it a zone of thermal influence, which, depending on the carbon content in the steel, has a different structure: ferrite-pearlite, martensitic, troostomartensitic, martensiticpearlitic. It has been established that laser microstructuring of a pre-polished surface in some cases leads to an increase in the values of microhardness and the length of the laser exposure zone, which may be associated with an increase in the absorption capacity of the material of the polished surface and, accordingly, a decrease in its reflectivity.

   Conclusion. The results obtained can be used in the creation of resource-saving material processing processes.
Gleason Pattern 5 May Be a Prognostic Factor in Radium-223 Treatment
Authors: NISHIMOTO MITSUHISA , FUJITA KAZUTOSHI , RI ARITOSHI , FUJIMOTO SAIZO , OGUMA YASUO , TOYODA SHINGO , HASHIMOTO MAMORU , KIKUCHI TAKASHI , ADOMI SHOGO , SAITO YOSHITAKA , MORI YASUNORI , MINAMI TAKAFUMI , NOZAWA MASAHIRO , YOSHIMURA KAZUHIRO , HOSONO MAKOTO , UEMU HIROTSUGU
Published: July 2024

Background/Aim: Radium-223 treatment reduces the risk of death in patients with metastatic castration-resistant prostate cancer (CRPC). This study analyzed the prognostic factors in patients treated with radium-223 dichloride. Patients and Methods: Patients who received radium-223 dichloride were retrospectively analyzed. Prostate-specific antigen (PSA) response and alkaline phosphatase (ALP) decline rates were analyzed. Overall survival (OS) was evaluated using Kaplan–Meier curves, and prognostic factors for OS were assessed using Cox proportional hazards analysis. Results: Fifty-six patients were included in the study. The five-year OS rate in patients after diagnosis of CRPC was 62.2% [95% confidence interval (CI)=27.55-112.45], while the five-year OS rate in patients at the initiation of radium-223 treatment was 21.3% (95%CI=17.20-36.79). Six patients (11.1%) had a >50% PSA decline rate, and 10 (17.9%) had a >50% ALP decline rate. Cox proportional hazards analysis showed that PSA levels at the initiation of radium-223 treatment [hazard ratio (HR)=1.00; 95%CI=1.00-1.00; p=0.0054] and Gleason Pattern (GP) 5 (HR=5.42; 95%CI=1.08-27.27; p=0.0400) were associated with OS. Patients with GP 5 had a significantly poorer prognosis compared with patients with a GP ≤4. Early administration of radium-223 as a first- or second-line treatment was not associated with OS compared with late administration of radium-223 as a third-line or later treatment. Conclusion: GP 5 and high PSA levels at radium-223 initiation were associated with worse OS. Radium-223 as first- or second-line treatment was not associated with OS. Therefore, a treatment strategy for CRPC based on GP 5 is needed.
Radiotherapy for Solitary Bony or Extramedullary Plasmacytoma
Authors: KATANO ATSUTO , SAWAYANAGI SUBARU , MINAMITANI MASANARI , OHIRA SHINGO , YAMASHITA HIDEOMI
Published: July 2024

Background/Aim: This study aimed to determine the oncological outcomes associated with curative radiotherapy for solitary bony or extramedullary plasmacytomas by drawing on clinical data from a single tertiary center. This study aimed to provide a comprehensive understanding of the efficacy of radiotherapeutic interventions and delineate the patterns of disease recurrence. Patients and Methods: Eleven consecutive patients diagnosed with solitary bony or extramedullary plasmacytomas and treated between May 2007 and November 2023 were retrospectively screened. Different radiotherapy doses and fractionations were employed, and statistical analyses were performed to assess overall survival (OS) and disease-free survival (DFS). Results: Among the 11 patients (9 males and 2 females), primary tumors were located within the bone in seven patients, whereas extramedullary tumors were observed in four patients. The median prescribed radiation dose was 46 Gy. The 5-year OS and DFS were 83.3% and 28.9%, respectively. Progression to multiple myeloma occurred in four patients with primary bony plasmacytoma. Local control rate was 88.9%, and one patient experienced distant metastasis after 32 months. Bony plasmacytoma has a high tendency of leading to multiple myeloma rather than extramedullary plasmacytoma (5-year progression to multiple myeloma-free survival rate, 20.8% vs. 100%, p=0.08). Conclusion: Radiotherapy is effective for solitary plasmacytomas with favorable local control and high objective response rates. A comparison with the existing literature supports the role of radiotherapy in the management of these conditions. The differences in outcomes between bony and extramedullary plasmacytomas emphasize the need for personalized treatment approaches.
Prognostic Impact of the Administration of Antibiotics and Proton Pump Inhibitors in Immune Checkpoint Inhibitor Combination Therapy for Advanced Renal Cell Carcinoma
Authors: KATSURAYAMA NANAKA , ISHIHARA HIROKI , ISHIYAMA RYO , NEMOTO YUKI , IKEDA TAKASHI , MIZOGUCHI SHINSUKE , NAKAYAMA TAKAYUKI , FUKUDA HIRONORI , YOSHIDA KAZUHIKO , IIZUKA JUNPEI , SHINMURA HIROAKI , HASHIMOTO YASUNOBU , KONDO TSUNENORI , TAKAGI TOSHIO
Published: July 2024

Background/Aim: The prognostic impact of the administration of antibiotics and proton pump inhibitors (PPIs) in immune checkpoint inhibitor (ICI) therapy for advanced cancer has recently been documented. However, how these drugs affect the outcomes of first-line ICI combination therapy for advanced renal cell carcinoma (RCC) remains unclear. Patients and Methods: We retrospectively evaluated the data of 128 patients with RCC who received first-line ICI combination therapy. The patients were grouped according to their history of antibiotics and PPIs use one month before the initiation of ICI combination therapy. Progression-free survival (PFS), overall survival (OS), and objective response rate (ORR) after ICI combination therapy were compared between patients treated with and without antibiotics or PPIs. Results: Of the 128 patients, 30 (23%) and 44 (34%) received antibiotics and PPIs, respectively. Patients treated with antibiotics exhibited shorter PFS and OS compared to those who did not receive antibiotics (median PFS: 4.9 vs. 16.1 months, p<0.0001; OS: 20.8 vs. 49.0 months, p=0.0034). Multivariate analyses showed that antibiotic administration was an independent predictor of shorter PFS (hazard ratio: 2.54: p=0.0002) and OS (hazard ratio: 2.56: p=0.0067) after adjusting for other covariates. In contrast, there were no significant differences in either PFS or OS between patients who received PPIs and those who did not. (PFS: p=0.828; OS: p=0.105). Conclusion: Antibiotics administration before ICI combination therapy was negatively associated with outcomes of first-line ICI combination therapy for advanced RCC. Therefore, careful monitoring is required for potentially high-risk patients undergoing ICI combination therapy.
Body Composition and Energy Expenditure in Youth With Spina Bifida: Protocol for a Multisite, Cross-Sectional Study
Authors: Polfuss Michele , Smith Kathryn , Hopson Betsy , Moosreiner Andrea , Huang Chiang-Ching , Ravelli Michele N , Ding Dan , Huang Zijian , Rocque Brandon G , White-Traut Rosemary , Van Speybroeck Alexander , Sawin Kathleen J
Published: July 2024

Background

Obesity prevalence in youth with spina bifida is higher than in their typically developing peers. Obesity is associated with lifelong medical, psychological, and economic burdens. Successful prevention or treatment of obesity in individuals with spina bifida is compromised by (1) the lack of valid and reliable methods to identify body fat in a clinical setting and (2) limited data on energy expenditure that are necessary to provide daily caloric recommendations.

Objective

The objectives of this study will be to develop 2 algorithms for use in youth with spina bifida in a clinical setting, one to model body fat and one to predict total daily energy expenditure. In addition, physical activity and dietary intake will be described for the sample.

Methods

This multisite, prospective, national clinical study will enroll 232 youth with myelomeningocele aged 5 to 18 years (stratified by age and mobility). Participants will be enrolled for 1 week. Data obtained include 4 measures of body composition, up to 5 height measures, a ramped activity protocol, and a nutrition and physical activity screener. Participants will wear an accelerometer for the week. On the final study day, 2 samples of urine or saliva, which complete the doubly labeled water protocol, will be obtained. The analysis will include descriptive statistics, Bland-Altman plots, concordance correlation, and regression analysis.

Results

The study received extramural federal funding in July 2019. Data collection was initiated in March 2020. As of April 2024, a total of 143 (female participants: n=76, 53.1%; male participants: n=67, 46.9%) out of 232 participants have been enrolled. Data collection is expected to continue throughout 2024. A no-cost extension until November 2025 will be requested for data analysis and dissemination of findings.

Conclusions

This study furthers previous pilot work that confirmed the acceptability and feasibility of obtaining alternate height, body composition, and energy expenditure measures. The findings from this study will enhance screening, prevention, and treatment of abnormal weight status by facilitating the accurate identification of youths’ weight status category and recommendations of daily caloric needs for this population that is at higher risk of obesity. Furthermore, the findings have the potential to impact outcomes for youth diagnosed with disabilities other than spina bifida who experience similar challenges related to alterations in body composition or fat distribution or measurement challenges secondary to mobility issues or musculoskeletal problems.

International Registered Report Identifier (IRRID)

DERR1-10.2196/52779
Distinct effects of social support from family and friends on smartphone addiction among depressed adolescents: The role of loneliness and expressive suppression (Preprint)
Authors: Huo LIjuan
Published: July 2024

BACKGROUND

Smartphone addiction (SA) is a growing concern, especially among adolescents with depression. This study investigates the nuanced relationship between perceived social support (from family and friends/significant others), loneliness, expressive suppression, and SA in a large sample of depressed adolescents.

OBJECTIVE

The present study aims to investigate the mechanisms underlying the association between perceived social support and SA in depressed adolescents and explore the role of loneliness in this pathway. Further, it aims to differentiate and compare the potential effects of two different sources of social support (i.e., perceived social support from family and friends/significant others) on SA. Additionally, it explores the moderating role of expression inhibition in the relationships between perceived social support, loneliness, and SA.

METHODS

Data were collected from 2,341 Chinese adolescents (12-18 years old) diagnosed with depression. Perceived social support, loneliness, smartphone addiction, and expressive suppression were assessed using validated questionnaires. Structural equation modeling was employed to test the hypothesized relationships.

RESULTS

Loneliness was found to mediate the relationship between perceived social support and SA. Notably, perceived social support from family negatively predicted SA, while perceived social support from friends/significant others positively predicted SA. Expressive suppression moderated the association between perceived social support from friends/significant others and loneliness but not the association between family support and loneliness.

CONCLUSIONS

The study underscores the importance of differentiating between sources of social support when examining their impact on SA in depressed adolescents. Loneliness plays a crucial role in the pathway from perceived social support to SA, and emotional suppression may exacerbate this pathway when friend support is low. These findings have significant implications for the development of tailored interventions aimed at mitigating SA in this vulnerable population.
Munculnya Krapyak dan Perubahan Lingkungan di Mataram pada Abad ke-17
Authors: Afwakhoir Rifki
Published: July 2024

Humans have been hunting animals for thousands of years. Hunting activities can no longer be seen as simply killing animals. Hunting has such a broad meaning. In the 17th century, Mataram kings did hunting as a habit in krapyak. This name of area is a large area surrounded by a wooden fence filled with animals. The Mataram kings could freely hunt without fearing being attacked by wild animals. The king’s habit of hunting in krapyak was often thought of merely as a pastime. This research attempts to scrutinize the effect of the development of krapyak environmental change at Mataram in the 17th century through literature study. Then, the study used both resources, primary and secondary historical data. An anthropocentric approach and materialism-historical analysis were used to understand the damage caused by the development of krapyak and the environmental change that occurred. This research shows that hunting in krapyak is not merely seen as a king’s pastime, but also affirms territorialization and implicitly legislates wildlife ownership. The presence of it also indicated environmental changes in the Mataram area in the 17th century.
The Effect of Purified Catechins from Gambier on the Physico-Chemical Characteristics of Functional Solid Shampoo
Authors: Syukri Daimon , Rini Rini , Husna Wahdinil , Dini Hari Purnama , Permata Sari Fitria Indah , Wibisono Irtati Hasan
Published: July 2024

Gambier is a natural product that contains high amounts of cathechin. Cathechin has bioavailability as an antimicrobial such as fungus. Dandruff is a problem on the human scalp caused by fungus where this condition can be treated by using shampoo.The purpose of this study was to ascertain how the properties of solid shampoo were affected by the catechin extract from Gambier. This study's design comprised three replicates and five treatments in a fully randomized fashion. Catechin extract was added to the shampoo in amounts of 0, 1, 2, 3, and 4% of the total contents. Evaluations were conducted on the created shampoo's chemical, physical, and organoleptic properties. By the measurement of pH, percentage of solid content, foam height, texture, color, and scent revealed that the addition of gambier catechin extract could had a substantial influence (α = 5%) but not for dirt dispersal. Adding 4% of Gambier's catechin extract to the solid shampoo resulted in the optimal concentration. Further studies are needed to ascertain the specific role of the Gambier catechin extract in solid shampoo in order to fully appreciate the benefits of using it in shampoo products.
Assessing the Impact of ICT Infrastructure on Card-Based Non-Cash Transaction Volumes in Indonesia
Authors: Fariki La , Natsir Muhammad , Hasddin Hasddin , Sultraeni Wiwin
Published: July 2024

This research aims to analyze the influence of Information and Communication Technology (ICT) infrastructure on the volume of card-based non-cash financial transactions in Indonesia from 2019 to 2021. This is a quantitative study. Data analysis in this research employs multiple regression with a fixed-effect model. The study utilizes panel data of longitudinal type, consisting of data on Base Transceiver Stations (BTS), Villages/Subdistricts Served by Internet, Automatic Teller Machines (ATMs), ATM/debit cards and credit cards, and non-cash financial transaction volume based on cards across 33 provinces in Indonesia as cross-sectional data, spanning a period of three (3) years from 2019 to 2021 as time-series data. Secondary data for this research were obtained from the Bank of Indonesia, the Central Bureau of Statistics, and the Financial Services Authority. Base Transceiver Station (BTS), Villages/Kelurahan Served by Internet, Automated Teller Machines (ATM), ATM/Debit Cards, and Credit Cards simultaneously have a significant influence on the volume of card-based non-cash finance. Automated Teller Machines (ATMs), ATM/debit cards, and credit cards have a significant influence on the volume of card-based non-cash financial transactions. The research findings are that although ATM and card services significantly increase transaction volume, BTS and internet services in villages/districts do not show a significant impact.
Property Development, Management and Appraisal as a Panacea to Church Growth Branding and Remodeling in Nigeria
Authors: Chikwuado Emenike Kingsley , Kalu Okoro Michael
Published: July 2024

Abstract: This study is focused on examining the property development and management strategy that can lead to Church Growth, identifying both natural and human resources that can resuscitate the state of church properties at the urban, suburban and rural levels respectively for a healthy and sustainable environment through employing modern approaches that reveals and explore latent property values imbedded in church properties. The paper adopted both primary and secondary source for data collection. The findings show that lack of some professional skill in modern real estate practice has really affected church properties. The study recommends joint collaboration within the church and professional team, and a routine appraisal of church properties will always restore, preserve and improve God’s property the church.
Images Spam Detection on Online Social Media using CNN with Pre-Trained Model
Authors: Jain Himani
Published: July 2024

Abstract: Nowadays attackers move to image spam techniques instead of text based. The Majority of conventional techniques solely possess the capability to identify spam confined to textual content and hyperlinks. In this research we have done “Deep Convolutional Neural Networks” (DCNNs)in conjunction with pre-trained architectures. Image classification is one of the areas that has increased in the last decade very rapidly. But due to the less computational resources it become very challenging to train a good image classification model. With the help of Transfer learning, we can overcome this type of situation and can build a good image classification model. Our proposed model utilizes deep convolutional neural networks (DCNNs) along with pre-trained architectures. By fine-tuning this pre-trained model on the specific image dataset, the model can effectively learn to detect image- based spam content. Our suggested model surpasses contemporary state-of-the-art detection models concerning both accuracy and efficiency in the realm of the image spam identification.
Liquid Flow Control System Using Arduino Microcontroller
Authors: Warke Punam P.
Published: July 2024

Abstract: An automated system presented here is designed to control the flow of fluid or liquid. The system uses automated peristaltic Pump to control the liquid flow. The peristaltic pump used here is designed and developed by the author according to the requirement of the application. The stepper motor movement of pump is controlled by using Arduino Microcontroller. Liquid flow through the pump is controlled in two ways: Automatic and manual mode. Such systems can be used in small industries for fluid separation from slurry or slug. Also can used where pre described amount of liquid or fluid is required in application.
A Deep Learning Approach to Text-to-Video Generation
Authors: Gawade Shruti
Published: July 2024

Abstract: In the ever-evolving landscape of multimedia content creation, there is a growing demand for automated tools that can seamlessly transform textual descriptions into engaging and realistic videos. This research paper introduces a state-of-the-art Text to Video Generation Model, a groundbreaking approach designed to bridge the gap between textual input and visually compelling video output. Leveraging advanced deep learning techniques, the proposed model not only captures the semantic nuances of the input text but also generates dynamic and contextually relevant video sequences. The model architecture combines both natural language processing and computer vision components, allowing it to understand textual descriptions and transform them into visually cohesive scenes.. Through a carefully curated dataset and extensive training, the model learns to understand the intricate relationships between words, phrases, and visual elements, allowing for the creation of videos that faithfully represent the intended narrative. The incorporation of attention mechanisms further enhances the model's ability to focus on key details, ensuring a more nuanced and accurate translation from text to video.
YOLO Models for Security and Surveillance Applications
Authors: Bajpai Manas
Published: July 2024

Abstract: Since 2015, the YOLO (You Only Look Once) series has evolved to YOLO-v8, prioritizing real-time processing and high accuracy for security and surveillance applications. Architectural enhancements in each iteration, culminating in YOLOv9, cater to rapid detection, precision, and adaptability to resource-constrained edge devices. This study examines YOLO’s evolution, emphasizing its relevance to security and surveillance contexts. Notable improvements in architecture, coupled with practical deployments for defect detection, underscore YOLO’s alignment with stringent security and surveillance requirements.
Determine Biofilm Genes in Pseudomonas Aeruginosa Isolated from Clinical and Environmental Samples
Authors: AL-Mashhadani Riyam Khalid Attallah , AboKsour Mohammed Fadhil , Dakhil Osama Abdul Azeez
Published: July 2024

Objective: Isolates of Pseudomonas aeruginosa are an extremely adaptable bacterium that causes opportunistic diseases because of its varied metabolic pathways, genes, virulence factors, and considerable antibiotic resistance.
Methods: A total of 293 samples were collected from different places: 193 samples (% 65.87) of human samples and 100 samples (% 34.13) of wastewater samples in the period between 3rd September to 15th November 2023). Bacterial isolates were identified according to microscopic, cultural, and genetic characteristics. Antibiotic susceptibility of bacterial isolates was determined against twelve of the selected antibiotics. The biofilm production was done by using phenotypic ways (Congo red agar and Microtiter plate methods) as well as genotypic ways by detection of biofilm genes (algD, pelf, and pslD genes).
Results: Hundred-forty eight bacterial isolates were obtained, and sixty of these isolates were identified as Pseudomonas spp. (40.9%), twenty-six isolates of E. coli (17.9%), seventeen isolates of K. pneumoniae (11.3%), and forty-five isolates were beyond to other types of bacteria (30.1%), and out of sixty isolates of Pseudomonas spp., forty-two were identified as P. aeruginosa isolates. P. aeruginosa isolates revealed various resistance levels to antimicrobial agents gradually, ranging from 83.87% to Trimethoprim-sulfamethoxazole (SXT) to 3.22% to Aztreonam (AZT). Biofilm production by using the Congo red method showed that 27 isolates (64.28%) were positive results, while in the microtiter method, all forty-two isolates were positive (100%), the genetic detection showed that the AlgD gene was recognized in thirty-one isolates (73.8%), followed by Pelf and PslD genes in four isolates each (9.5%).
Conclusion: The isolation percentage showed a high occurrence of multi-drug resistance biofilm forming Pseudomonas spp. isolates which could be a critical indicator. Methods of biofilm detection showed that the microtiter plate method has accuracy more than the Congo red method; as well AlgD gene was prevalent compared with both other genes Pelf, and PslD.