bluuebunny/crossref_metadata_2025 huggingface dataset:
Unsupervised cross talk suppression for self-interference digital holography
Authors: Huang Tao , Yang Le , Zhang Weina , Dou Jiazhen , Di Jianglei , Wu Jiachen , Rosen Joseph , Zhong Liyun
Published: January 2025

Self-interference digital holography extends the application of digital holography to non-coherent imaging fields such as fluorescence and scattered light, providing a new solution, to the best of our knowledge, for wide field 3D imaging of low coherence or partially coherent signals. However, cross talk information has always been an important factor limiting the resolution of this imaging method. The suppression of cross talk information is a complex nonlinear problem, and deep learning can easily obtain its corresponding nonlinear model through data-driven methods. However, in real experiments, it is difficult to obtain such paired datasets to complete training. Here, we propose an unsupervised cross talk suppression method based on a cycle-consistent generative adversarial network (CycleGAN) for self-interference digital holography. Through the introduction of a saliency constraint, the unsupervised model, named crosstalk suppressing with unsupervised neural network (CS-UNN), can learn the mapping between two image domains without requiring paired training data while avoiding distortions of the image content. Experimental analysis has shown that this method can suppress cross talk information in reconstructed images without the need for training strategies on a large number of paired datasets, providing an effective solution for the application of the self-interference digital holography technology.
Optical engineering of the 3D quantum Hall effect in Floquet Weyl semimetals
Authors: Su Xiaolin , Wang Tiancheng , Li Minghao , Li Yang , Xu Gaofeng , Jia Fanghao , Li Ruixue , Liu Wu-Ming , Li Yuan
Published: January 2025

We study the optical modulation of the three-dimensional (3D) quantum Hall effect in Weyl semimetals by using the four-terminal Hall-bar probing geometry. By utilizing the Floquet theorem, we calculate the Hall conductance under the combined effect of the circularly polarized light (CPL) and the perpendicular magnetic field. The Hall conductance plateaus change from negative values to positive values induced by the left-handed CPL. Moreover, the Hall conductance plateaus keep negative values under the action of the right-handed CPL. Accordingly, the chiral dependence of the Hall conductance can be elucidated in terms of the optical modulation of the spatial distribution of the probability density and the Landau levels induced by the CPL. The Hall conductance depends on the thickness of the Weyl semimetals and is robust against the on-site strong disorders. This work will be instructive for realizing an effective optical modulation of the Weyl orbitals in Weyl semimetals.
Unknown weak light pulse measurement using time interval distribution photon counting
Authors: Zhu Xinyi , Wang Yurong , Li Xue , Li Zhaohui , Pan Haifeng , Chen Xiuliang , Zhang Pengcheng , Huang Kun , Wu Guang
Published: January 2025

In this paper, we present a method for measuring weak light pulses using a single-photon detector, with a focus on detecting non-synchronized repetitive pulsed light. The proposed approach, based on interval distribution counting, enables accurate reconstruction of both the repetition rate and phase of weak pulses, facilitating the determination of the average photon number and pulse width. Specifically, the error in reconstructing the repetition rate is below ±0.01%, while the error in measuring the photon number per pulse remains below ±0.8%.
Optical amplification ranging from 1600 to over 1680 nm in thulium-doped fluorotellurite glass fibers with a terbium-doped cladding
Authors: Zhang Chuanze , Jia Zhixu , Wang Junjie , Wang Fangning , Ren Yingshuai , Meng Fanchao , Ohishi Yasutake , Qin Weiping , Qin Guanshi
Published: January 2025

We demonstrated optical amplification ranging from 1600 to over 1680 nm in Tm3+-doped fluorotellurite fibers (FTFs) with a Tb3+-doped cladding by using a 1212 nm fiber laser as the pump source. The FTFs based on TeO2–BaF2– Y2O3 glasses were fabricated by using a rod-in-tube method. The doping concentration of Tm3+ ions in the core was about 4000 ppm and that of Tb3+ ions in the fiber cladding was about 10,000 ppm. By introducing the Tb3+ ions into the cladding, the emission in the long-wavelength region (>1750 nm) originating from the transition 3F4→3H6 of Tm3+ ions was suppressed efficiently by broadband absorption (1700–2100 nm) originating from the transitions 7F6→7F0,1,2 of the Tb3+ ions in the cladding. As a result, a positive net gain ranging from 1600 to over 1680 nm was achieved in a 1.5 m long Tm3+-doped FTF as the launched power of the 1212 nm laser was about 3 W. The gain value at 1675 nm was about 19.7 dB for an input signal power of ∼0 dBm (or 1 mW). The gain was gradually reduced for shorter wavelengths, but it was still above 10 dB at ∼1644 nm. Our results show that Tm3+-doped FTFs with a Tb3+-doped cladding are promising gain media for constructing fiber amplifiers and lasers in the wavelength region of 1600–1700 nm.
Topological phase transitions and switchable edge states for the non-Hermitian Aubry–André–Harper model in photonic crystals
Authors: Wang Luchi , Tang Jie , Dai Xiaoyu , Xiang Yuanjiang
Published: January 2025

The Aubry–André–Harper (AAH) model with imaginary periodic or quasiperiodic modulations could regulate the local properties of the system. In this work, we apply the non-Hermitian AAH potential field to the photonic system induced by gain and loss. It is found that the potential field with different parameters will cause the system to exhibit different local properties and induce different localized edge states under the open boundary conditions. Moreover, we investigated the influence of non-Hermitian AAH potential parameters on the edge states of the Haldane model under periodic boundary conditions. It is shown that two-dimensional magnetic photonic crystals can undergo topological transitions and switchable edge states by tuning the potential field parameters. This offers a versatile method for controlling optical flow in photonic platforms.
Photonic skin for photonic-integration-based wearable sensors
Authors: Li Hongqiang , Li Xiaolin , Yang Yueting , Xie Fanglin , Han Ming , Lin Zhilin , Wang Yingjie , Zhang Junqu , Zhang Shanshan , Zhang Cheng , Cao Lu , Li Enbang
Published: January 2025

Skin-like flexible electronics (electronic skins) placed on human skin can be used for real-time measurement of the vital signs of the human body. Photonic sensors are a compelling alternative to electronic sensors owing to their small sizes, high sensitivity, high accuracy, large capabilities, and cost efficiency. Here we present a photonic skin primarily comprising waveguide Bragg gratings and a Mach–Zehnder modulator, enabling body temperature, blood glucose, and electrocardiogram measurements. A polymer-based photonic chip (1cm×0.45cm) was fabricated on polydimethylsiloxane using a mature process. A photonic chip and flexible signal-processing module were integrated with super-luminescent light-emitting-diode chips, photodetector arrays, and wireless communication circuits to create this photonic skin. The findings of this study demonstrate the applicability of the photonic skin in healthcare, offering insights into wearable optical sensing.
The Cul3 ubiquitin ligase engages Insomniac as an adaptor to impact sleep and synaptic homeostasis
Authors: Li Qiuling , Lim Kayla Y. , Altawell Raad , Verderose Faith , Li Xiling , Dong Wanying , Martinez Joshua , Dickman Dion , Stavropoulos Nicholas
Published: January 2025

Mutations of the Cullin-3 (Cul3) E3 ubiquitin ligase are associated with autism and schizophrenia, neurological disorders characterized by sleep disturbances and altered synaptic function. Cul3 engages dozens of adaptor proteins to recruit hundreds of substrates for ubiquitination, but the adaptors that impact sleep and synapses remain ill-defined. Here we implicate Insomniac (Inc), a conserved protein required for normal sleep and synaptic homeostasis in Drosophila, as a Cul3 adaptor. Inc binds Cul3 in vivo, and mutations within the N-terminal BTB domain of Inc that weaken Inc-Cul3 associations impair Inc activity, suggesting that Inc function requires binding to the Cul3 complex. Deletion of the conserved C-terminus of Inc does not alter Cul3 binding but abolishes Inc activity in the context of sleep and synaptic homeostasis, indicating that the Inc C-terminus has the properties of a substrate recruitment domain. Mutation of a conserved, disease-associated arginine in the Inc C-terminus also abolishes Inc function, suggesting that this residue is vital for recruiting Inc targets. Inc levels are negatively regulated by Cul3 in neurons, consistent with Inc degradation by autocatalytic ubiquitination, a hallmark of Cullin adaptors. These findings link Inc and Cul3 in vivo and support the notion that Inc-Cul3 complexes are essential for normal sleep and synaptic function. Furthermore, these results indicate that dysregulation of conserved substrates of Inc-Cul3 complexes may contribute to altered sleep and synaptic function in autism and schizophrenia associated with Cul3 mutations.
A CRISPR-Cas12a-based universal rapid scrub typhus diagnostic method targeting 16S rRNA of Orientia tsutsugamushi
Authors: Park Bum Ju , Heo Sang Taek , Kim Misun , Yoo Jeong Rae , Bae Eun Jin , Kang Su Yeon , Park Sunghoon , Han Kyeo Re , Lee Keun Hwa , Lee Jae Myun , Lee Hyeyoung , Song Yoon-Jae
Published: January 2025

Scrub typhus is caused by Orientia tsutsugamushi infection and occurs frequently in an area called the Tsutsugamushi Triangle. Currently, there is no vaccine for O. tsutsugamushi, and its infection is treated with antibiotics such as doxycycline. Scrub typhus responds to effective treatment, and early treatment shortens the course of the disease, reduces mortality, and accelerates recovery. Therefore, it is important to rapidly diagnose O. tsutsugamushi infection to ensure successful outcomes. Here, we developed a CRISPR-Cas12a-based diagnostic method targeting the bacterial 16S rRNA to detect O. tsutsugamushi infection of all known genotypes. To reduce the possibility of contamination and increase field applicability, we designed the one-pot assay system in addition to conventional two-pot assay system. Using this method, we successfully detected up to 100 copies of in vitro transcribed O. tsutsugamushi 16S rRNA within 1 hour under isothermal conditions. In blood samples from patients confirmed to be infected with O. tsutsugamushi by nested PCR, the developed method exhibited a clinical sensitivity of 98% and high specificity. These data demonstrate that the presented method is applicable for the rapid and universal diagnosis of scrub typhus to facilitate timely and appropriate treatment.
Fatherless Child Pada Wakana Gojo Dalam Anime Sono Bisque Wa Koi Wo Suru Karya Keisuke Shinohara
Authors: Hendra Ivonne
Published: January 2025

The study was titled Fatherless Child In Wakana Gojo in Keisuke Shinohara's Sono Bisque Doll Wa Koi Wo Suru anime. This study analyzed the depiction of a fatherless child and the efforts of the character Wakana Gojo to overcome his fatherless child. Wakana Gojo is the main character in the anime sono bisque doll wa koi wo suru which shows maladaptive behavior such as difficulty in social relationships with people around him, despair, emptiness, and fear of rejection. This study used unstructured observation methods, descriptive observation. The theories used in analysis are the psychological theory of literature and the theory of semiotics. The analysis results in this study show Wakana Gojo's fatherless behavior, namely: 1) Fear of rejection; 2) Loss of trust in others and withdrawing from the social environment. Wakana Gojo's fatherless attitude was due to his father's abandonment at a young age. Although Wakana Gojo has received love from the grandfather who raised him, it is still not enough, because of an empty hole in his heart.
Representasi Hatarakisugi pada Tokoh Aoyama Takashi dalam Film Chotto Ima Kara Shigoto Yamete Kuru karya Izuru Narushima
Authors: Kitai Taro
Published: January 2025

This research is titled "The representation of hatarakisugi on the character Aoyama Takashi in the movie Chotto Ima Kara Shigoto Yamete Kuru by Izuru Narushima. This research focuses on showing the representation of hatarakisugi and the impact of hatarakisugi on the character Aoyama Takashi in the movie Chotto Ima Kara Shigoto Yamete Kuru. The method used in this research is descriptive qualitative method, the data source of this research is the movie Chotto Ima Kara Shigoto Yamete Kuru. The theories used are literary psychology theory by Wellek and Warren, literary sociology theory by Damono, and semiotics theory by Danesi. Based on the results of the study, it is known that the representation of hatarakisugi that occurs in the character Aoyama Takashi includes; 1) a wrong mindset; 2) neglecting personal health; and 3) forcing oneself to overwork. The positive and negative impacts of hatarakisugi on the character Aoyama Takashi in the movie Chotto Ima Kara Shigoto Yamete Kuru (2017) by Izuru Narushima. The positive impacts are; 1) fostering an unyielding attitude; 2) fostering a high discipline attitude; and 3) daring to make decisions. While the negative impacts are; 1) decreased motivation; 2) stress; 3) Depression; and 3) suicidal thoughts.
Perwujudan Konsep On Pada Tokoh Frieren dan Heiter Dalam Anime Sousou No Frieren Karya Kanehito Yamada
Authors: Indriani Emilia Fortuna , Santoso Budi
Published: January 2025

This study is intended to determine how the embodiment of the value of on, gimu, and giri in the characters Frieren and Heiter in the anime Sousou no Frieren by Kanehito Yamada. The author uses descriptive qualitative method. This research design uses literary anthropology, which leads to literary text research that examines literary reflections as cultural reflections.  The data source was taken from Muse Indonesia's Youtube channel video entitled "Frieren: Beyond Journey's End" on episode 1-2. Frieren receives more on, giri, and gimu than Heiter because Frieren does not understand the concept of gratitude. She has a cold personality and lacks the ability to understand how quickly time passes for humans. After understanding the concept, Frieren tried to repay the debt of gratitude she had not been able to do. Frieren is able to pay his debt or giri in a timely manner. Heiter understood the concept of on so he did not carry as much of the burden of the values of on, giri and gimu as Frieren. Frieren and Heiter both carried the gimu ko to Himmel. Heiter managed to complete his gimu because he really took care of Fern until the end of his life. Frieren, on the other hand, had done her gimu and continued her gimu as part of her life principles. It can be concluded through this anime, Japan still maintains the moral concepts of on, giri and gimu.
Interferensi Fonologi Wasedaboys terhadap Nama-Nama Daerah Indonesia pada Vlog Nihongo Mantappu
Authors: Rahardjo Hardianto
Published: January 2025

Interference is a mistake that is generally made by second language learners because of the influence of their first language skills.  Meanwhile, phonological interference is an error that occurs at the sound level due to changes in phonemes that are influenced by knowledge of the sound system in the first language.  This proposal discusses the mistakes of second language learners (in this case, Wasedaboys) in understanding sound changes that occur in the language being studied (Indonesian).  This study aims to describe the forms and factors that cause phonological interference by Wasedaboys in writing the names of regions in Indonesia in the vlog "Nihonggo Mantappu" entitled "quiz spelling Indonesian regional names w/ wasedaboys!  How ridiculous!  The method used in this research is descriptive qualitative method with theory referring to Weinrich's (1953) interference theory.  The data collection method used is the listening method with the proficient free engagement technique.  Based on the data that has been obtained, the forms of phonological interference found are classified into forms of interference with phoneme changes, interference with the addition of phonemes and forms of interference with phoneme deletion in which the forms of interference mentioned above occur at the level of vowel and consonant phonemes.  The factors that cause phonological interference are (1) the bilingualism of the speech participants, totaling 3 data, (2) differences in vowel sounds and writing methods, totaling 11 data, (3) carrying over their mother tongue, totaling 3 data.Keywords: interference, phonology, vlog, Wasedaboys, Japan
Fenomena Covid-19 dalam Novel Burakku Shōman to Namonaki Machi no Satsujin Karya Keigo Higashino
Authors: Mandalle Mesy Pramaseilla , Anwar Fithyani
Published: January 2025

This research focuses on the Covid-19 phenomenon depicted in the novel Burakku Shōman to Namonaki Machi No Satsujin by Keigo Higashino. This research uses the theory of literary sociology proposed by Alan Swingewood, who considers literary works as a tool to observe phenomena that occur in society at a certain period. The purpose of this study is to explain how the phenomenon of Covid-19 in the novel Burakku Shōman to Namonaki Machi no Satsujin is depicted and how it was a reality in Japanese society at that time. This research method uses a descriptive qualitative method. This research data comes from the novel and data in the form of facts that occurred in Japan. The results of this study show that the novel Burakku Shōman to Namonaki Machi no Satsujin can describe the reality of Covid-19 that occurred in Japan in the form of activity restrictions by the government, the implementation of health protocols, the slump in the economy and tourism, to the cancellation of major projects and the postponement of international events such as the 2020 Tokyo Olympics. Based on the analysis results, the novel is indeed the reality in Japanese society during the Covid-19 pandemic.
Etika Bisnis dalam Kunjungan dan Pelayanan Tamu Jepang
Authors: Anaqi Amar Fawwas , Priventa Hendrike
Published: January 2025

This research aimed to identify business ethics that could be applied in visits and guest services for Japanese clients, considering the increasingly globalized business landscape. Given the necessity of collaborating with foreign partners, including Japanese individuals, this study employed a qualitative approach using observational methods based on the author's five years of experience in the Japanese business world. The findings revealed the importance of implementing appropriate ethics in all aspects of interaction, from airport pick-ups and in-car etiquette to hotel and dining manners, as well as accompanying guests on tours and receiving visitors at the company. Such practices fostered stronger relationships and enhanced trust with Japanese business partners. Business professionals needed to be adaptable and capable of building positive relationships with various stakeholders. Consequently, learning and applying business ethics was essential for any businessperson.
Assessing the pollutant removal potential of native reeds in sewage and paper mill effluents
Authors: Monica K B , Maheswari M , Dhevagi P , Kokiladevi E , Chitdeshwari T , Sivakumar U
Published: January 2025

Reed plants are cost effective method of remediating the wastewater. To test the removal efficiency of pollutants from sewage and paper mill effluents, four different reed plant species, Canna indica (Indian Shot), Colocassia esculenta (Taro), Typha domingensis (Southern Cattail) and Xanthosoma sagittifolium (Tannia), were compared for their removal efficiency of pollutants from sewage and paper mill effluents. Because of the high cost and limited effects of present physico-chemical treatments in wastewater treatment plant, this reed bed system can act as a cheaper process, that are essential to remove the organic pollutants, thus make them suitable for agricultural and irrigation purposes. In this study, initially, the raw effluent of sewage and paper mill was characterized. The four reed plants were separately screened with both the effluents by adopting the treatments for the four reeds and seven days retention time as two factors with 2 replications in pots. Each day, the treated effluent was collected from the pot and analysed. Up to day 7, the screening was done with both the effluents. The result shows that the Canna indica and Colocassia esculenta could be the better option for pollutant removal from the sewage and paper mill effluent respectively. The removal efficiency was higher in Canna indica (60%) for sewage wastewater and Colocassia esculenta (65%) for paper mill effluent. This removal percentage shows that the tolerating nature of the plants to the wastewater. The efficiency of the removal of pollutant by reeds can be further improved by bioaugmentation process which aids the action of microbes in the rhizosphere of the reed plants which may be used in the reed bed system.
Sensory acceptability of taperebá nectar formulation: physicochemical and microbiological characterization
Authors: Martins Ingryd Rodrigues , Figueiredo Carolina Araújo , Lins João Paulo de Melo , Martins Julia Helena da Silva , Martins Luiza Helena da Silva , Pelais Ana Carla Alves
Published: January 2025

Industries seek to expand the market for products that meet consumer expectations in terms of state and nutritional quality. Therefore, this study sought to develop taperebá nectar using Response Surface Methodology (RSM). Physicochemical (pH, total soluble solids and titratable acidity) and microbiological (coliforms, E. coli, Staphylococcos aureus and mesophilic aerobic bacteria) characteristics were evaluated in the pulp and in 11 taperebá nectar trials. Sensory acceptance was made on the nectars prepared, which was evaluated through the attributes state, overall impression and purchase intention. The nectars had a maximum pH of 3.25, titratable acidity (TA) of 0.74 g/100 g and total soluble solids (TSS) of 22.73 ºBrix. The nectars met legal standards for TSS while the pH and TA values, but not specified by legislation, were in line with other tropical nectars. The microbiological analysis showed results with acceptable limits for current legislation. Formulation 9, with 20.85% taperebá pulp and 14% sugar, was the most accepted in terms of state, overall impression and purchase intention. The MRS revealed that taperebá pulp had a linear effect on sensory acceptance, with the lowest percentages of pulp being the most preferred. The sugar content had a quadratic effect, but not significant (p ≥ 0.05). The nectar developed showed good acceptance by consumers for the attributes judged, with the provision of physical-chemical and microbiological characterizations, in accordance with Brazilian legislation, for the development of drinks based on taperebá.
Caracterização físico química e tecnológica de bolos adicionados de farinha de ora-pro-nóbis (Pereskia aculeata Miller)
Authors: Trentin Micheli , Bampi Marlene , Dinon Andréia Zilio
Published: January 2025

Pereskia aculeata Miller, também conhecida no Brasil como ora-pro-nóbis, possui alto teor de proteínas, fibras e minerais, sendo uma alternativa para alimentos mais nutritivos e saudáveis. O objetivo deste trabalho foi produzir e avaliar bolos com diferentes concentrações (10, 20, 30%) de farinha de ora-pro-nóbis (FO) associadas à redução do nível de óleo (5, 10, 15%), conforme delineamento experimental 2². Onde as variáveis independentes são o óleo (X1) e farinha de ora-pro-nóbis (X2), e as variáveis dependentes são as análise físico-químicas. Foram determinadas as propriedades físico-químicas e funcionais dos bolos. A adição de farinha de ora-pro-nóbis aumentou os teores de proteínas, fibras, cinzas, cálcio, sódio, magnésio, potássio e ferro. Também melhorou/aumentou os valores dos parâmetros a* e ΔE no miolo e a elasticidade. Bolos produzidos com 30% de FO apresentaram as melhores propriedades nutricionais. O bolo com adição de 20% e 10% de FO e 5% de redução no teor de óleo apresentou boa aceitabilidade sensorial, demonstrando que a adição de FO é uma alternativa para a elaboração de produtos alimentícios mais nutritivos.
Estudo de adsorção de corante vermelho Congo sobre materiais tipo Ni2O3/NaZSM-5
Authors: De jesus Santos Sara , Michelle Garrido Pedrosa Anne , Barros de Souza Marcelo José
Published: January 2025

Neste trabalho, foram desenvolvidos materiais do tipo Ni2O3/NaZSM-5 e avaliados na adsorção de corante vermelho Congo. A zeólita NaZSM-5 foi obtida a partir da zeólita NH4ZSM-5 comercial através de troca iônica e óxido de níquel(III) foi incorporado na NaZSM-5, em diferentes proporções, por mecanossíntese. Os adsorventes foram caracterizados utilizando adsorção e dessorção de N2, difratometria de raios X (DRX), microscopia eletrônica de varredura (MEV) e determinado o pH do ponto de carga zero (PCZ). Os resultados de remoção do vermelho Congo por adsorção em fase líquida mostrou que os adsorventes contendo óxido de níquel(III) (10% Ni2O3/NaZSM-5 e 20% Ni2O3/NaZSM-5) apresentaram eficiência de adsorção 5 e 9% maior do que a NaZSM-5. Estudos cinéticos mostraram que o modelo de pseudo segunda ordem exibiu o melhor ajuste com os dados experimentais com valores de R2 mais próximos da unidade. O estudo de reutilização dos adsorventes foi avaliado e apresentou resultados promissores.
Antileishmanial activity in silico and in vitro of semi-synthetic derivatives obtained from natural products
Authors: Barros Angela Maria Comapa , Ghilhon Simplicio Fernanda , Da Silva Pinto Ana Cristina , Lima de Oliveira Micael Davi , Nunes Figueiredo Victória , Yasmin Lima de Sousa Laiza , Ramos Franco Antonia Maria , Silva Lima Emersom
Published: January 2025

American cutaneous leishmaniasis (ACL) continues to be a public health problem in at least 85 countries around the world. Since medications for the treatment of ACL have toxic side effects, there is a need to search for new active molecules from plants. The objective of this study was to investigate the in vitro and in silico antileishmanial activity of semi-synthetic derivatives obtained from natural products. The bioassay used the species of Leishmania (L.) amazonensis and Leishmania (V.) guyanensis cultivated in supplemented RPMI medium. The 50% inhibitory concentration (IC50) was obtained by inhibiting promastigotes exposed to the solutions naringenin, aminoguanidine, CNFD, FGS-3, FGS-16 and FGS-18 at concentrations of 50 to 3.125 µg.mL-1. In the experiment, 0.2% DMSO and pentamidine isethionate at 3 µg.mL-1 were used as the controls for 24, 48 and 72 h, in triplicate. Regarding the interaction of the active ingredients with the enzymatic targets (2WP5 and 2VPM), molecular docking was used with the aid of the AutoDock Vina v.1.2.5. As for the derivatives FGS-16 and FGS-18, these presented spectra within those described in the literature. Regarding the 50% cytotoxic concentration (CC50) in cells after 72 h, FGS-18=329.9±0.3 µg.mL-1. The IC50 of FGS-16=0.7±0.2 µg.mL-1 for L. guyanensis and 0.5±0.6 µg.mL-1 for L. amazonensis.Therefore, the selectivity index was 45.7 (L. guyanensis) and 64 (L. amazonensis). Furthermore, the molecule presented three hydrogen bonds for the 2WPM target. Therefore, the FGS-16 proved to be the most promising derivative with antileishmanial activity.
The Issue of Diachronic Composition in Aristotelian Hylomorphism
Authors: Panayides Christos
Published: January 2025

One of the many puzzles in Aristotelian hylomorphism is this: What happens to matter when it comes to be enformed? Interpreters ascribe to Aristotle different theories of diachronic composition. Some of them assume that he endorses a view that contemporary metaphysicians label as ‘preservationism’: matter survives unchanged in the hylomorphic whole. Others take it that he accepts what nowadays is tagged as ‘annihilationism’: matter is annihilated and replaced by a new object, the one created by the union of matter and form. And yet others argue that he maintains that matter survives in the hylomorphic whole but it undergoes some significant changes, a thesis which, in modern metaphysical parlance, is labelled as ‘alterationism’. This paper does four things. First, it shows that none of these approaches to the issue at hand is satisfactory. Second, it examines some key passages in Physics I 7 and Generation and Corruption I 1-5 where Aristotle is often assumed to maintain incompatible views about coming to be. Third, it argues that there is no incompatibility between the positions presented in these texts. Finally, it shows that this same textual evidence sheds light on Aristotle’s views on what happens to matter when it comes to be enformed. He actually adopts different theories of diachronic composition for different hylomorphic wholes. He applies alterationism to non-substances and annihilationism to substances.
Hodge–Tate stacks and non-abelian 𝑝-adic Hodge theory of v-perfect complexes on rigid spaces
Authors: Anschütz Johannes , Heuer Ben , Le Bras Arthur-César
Published: January 2025

Let 𝑋 be a quasi-compact quasi-separated 𝑝-adic formal scheme that is smooth either over a perfectoid

Z
p

\mathbb{Z}_{p}

-algebra or over some ring of integers of a 𝑝-adic field.
We construct a fully faithful functor from perfect complexes on the Hodge–Tate stack of 𝑋 up to isogeny to perfect complexes on the v-site of the generic fibre of 𝑋.
Moreover, we describe perfect complexes on the Hodge–Tate stack in terms of certain derived categories of Higgs and Higgs–Sen modules.
This leads to a derived 𝑝-adic Simpson functor.
Fitness of Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) on four economically important host fruits from Fujian Province, China
Authors: Song Yunzhe , Lin Jia , Ouyang Xinru , Ren Zhizhuo , Luo Yilin , Ji Qinge , Hong Yongcong , Cai Pumo
Published: January 2025

Bactrocera dorsalis (Hendel) (Diptera: Tephritidae) is a highly polyphagous fruit fly pest of economic importance in regions of the world where it occurs. This pest is now established in most parts of Fujian Province, an important fruit-production region in China. However, basic life history information of B. dorsalis on different fruits in this region, which is crucial for developing more effective control approaches, is poorly known. The demographic parameters of B. dorsalis on four fruit types: navel orange (Citrus sinensis Osb. var. brasliliensis Tanaka; Rutaceae), carambola (Averrhoa carambola L.; Oxalidaceae), loquat [Eriobotrya japonica (Thunb.) Lindl.; Rosaceae], and persimmon (Diospyros kaki Thunb.; Ebenaceae) were determined. Results showed that all tested fruit types were suitable for population persistence of B. dorsalis, but the suitability varied. The developmental rate, intrinsic rate of increase (R
m), net reproductive rate (R
0), and finite rate of increase (λ) were significantly greater on persimmon compared with the other fruits. Under experimental conditions, fastest development, highest fecundity, highest survival, and heaviest pupal weight were observed on persimmon fruit, demonstrating that persimmon is a suitable host fruit for the growth and reproduction of B. dorsalis. The findings of this study will be valuable in the development of targeted control methods for managing B. dorsalis in orchards, with a particular focus on mixed orchards.
Cellulose particles filled oil-in-water emulsion: a facile strategy to prepare edible oleogels
Authors: Li Yanlei , Le Ying , Gao Zhiming , Jiang Wenxin , Wu Yuehan , Yuan Dan , Lu Wei , Chen Hui , Zhang Juan , Chen Zifang
Published: January 2025

In this work, a facile strategy of filling the O/W emulsions with cellulose particles to prepare edible oleogels was reported. Two preparation processes, particle filling in water phase of emulsion (PFWP) and one pot dispersing (OPD) are adopted. The effect of cellulose particle concentration and water content on the formation and properties of oleogels were evaluated. Results showed that both of the two processes (PFWP and OPD) could form an oleogels, within a wide range of particle concentration (20 wt% – 40 wt%) and water contents (15 wt% – 25 wt%). The formed oleogels have good centrifugal stability, thixotropic recovery properties and thermostability. The storage moduli of the oleogels increased with an increase of cellulose particle concentration, which is associated with the stronger capillary bridges network. Our results provide a fast and simple approach for oil structuring, which should have great potential application in food industry, especially in food bakery.
Polymer/phytochemical mediated eco-friendly synthesis of Cu/Zn doped hematite nanoparticles revealing biological properties and photocatalytic activity
Authors: Kumar Pankaj , Arya Vedpriya , Kumar Ashwani , Thakur Naveen
Published: January 2025

Unique magnetically recoverable copper/zinc-doped hematite nanoparticles, were synthesized by using a co-precipitation process with polymer polyvenylpyrodine and an aqueous extract of the Azadirachta indica plant serving as the capping and stabilizing agent. Hematite nanoparticles are the most stable form of iron oxide at room temperature, the presented work concentrated on the effects and comparisons of chemically and green synthesized doped materials that serve a dual role as reducing agents: supporting biomedical application and catalyzing environmental cleanup through photocatalysis. The prepared nanoparticles were characterized using X-ray diffraction, UV–vis spectroscopy, Fourier-transform infrared spectroscopy, Raman spectroscopy, vibrating-sample magnetometry, scanning electron microscopy, and transmission electron microscopy techniques to examine the produced material. The average grain size for doped hematite nanoparticles was found to be 13.33–19.90 nm based on X-ray diffraction measurements. The Fourier-transform infrared spectroscopy spectrum demonstrates the function of the biomolecules in the extract in capping the nanoparticles. The ferrimagnetic character of the produced nanoparticles demonstrated by the Vibrating-sample magnetometer investigation showed dependence at 300 K. According to the phytochemical study, A. indica has components that enhance its photocatalytic and antioxidant activity. In comparison, chemical/green synthesized doped hematite nanoparticles demonstrated noticeably higher photocatalytic activity for the oxidative breakdown of hazardous organic dyes Rhodamine blue and Congo red. Additionally, the photocatalyst displayed outstanding stability for the reaction. Radical scavenger assays 2,2-diphenyl-1-picrylhydrazyl and 2,2′-Azino-bis (3-ethylbenzothiazoline-6-sulfonic acid) were used to measure antioxidant capability. Based on the assay, the bran and husk fractions displayed higher levels of antioxidant activity. This research is regarded as a novel step in the production of doped hematite nanoparticles with particular photocatalytic and biological characteristics for wide use in environmental, and agricultural areas.
Tactical flight optimizer: a novel optimization technique tested on mathematical, mechanical, and structural optimization problems
Authors: Mortazavi Ali , Moloodpoor Mahsa
Published: January 2025

The current study presents a novel gradient-free metaheuristic search algorithm named Tactical Flight Optimizer (TFO), tailored to meet the growing need for high-performance optimization techniques in solving complex engineering and mathematical problems. The main contribution of this study is the development of a method that simulates tactical air combat formations, offering a sophisticated alternative to conventional search algorithms. In the proposed method, the location of each agent is updated based on a resultant vector derived from three updating vectors. The updating vectors incorporate total information stored by the agents in each iteration. Consequently, the navigation process is guided by a more logical mechanism rather than a simple random process. The search performance of the TFO is initially benchmarked by solving a set of constrained mathematical functions. Subsequently, it is evaluated by addressing a suite of constrained mechanical and structural problems, containing both discrete and continuous decision variables. The obtained results are compared with five other well-stablished metaheuristic techniques. Acquired numerical results indicate that the TFO algorithm can provide promising results in solving both mathematical and engineering problems in terms of computational cost, accuracy, and stability.
Fabrication and wear performance of M7C3 carbide reinforced epoxy composites
Authors: Yilmaz Serdar Osman , Teker Tanju , Kavak Sercan , Karakoca Alper
Published: January 2025

The role of materials in industrial engineering has become even more important today. Various methods are used to develop materials with desired properties. Cr7C3 carbide and grease oil reinforced epoxy-based matrix composites were produced. Microscopic analysis of the composites was carried out by SEM. The differences in the wear properties of the composites were investigated in dry sliding wear test. Increasing sliding speed and load increased the wear of the composites. Combining Cr7C3 with epoxy resulted in improved wear performance. The higher the chromium carbide level increased the coefficient of friction. The best wear resistance result was obtained from 75 wt.% chromium carbide reinforced composite. The change in wear resistance varied significantly depending on the epoxy resin ratio and the amount of reinforcement.
The diachrony of honorification in Chinese: stability and change
Authors: Chen Rong , Liu Fengguang , Liu Shiyu
Published: January 2025

In this paper, we study honorification in Chinese from a diachronic perspective. Classical Chinese is found to exhibit a large number of lexical items used to elevate other in discourse. The aspects that are elevated are specific titles, positions/statuses, knowledge/expertise, age/generation, taste/appearance and addressee in general. In contemporary Chinese, we find that some of these lexemes have disappeared, some have remained, and others have become restricted in use. At the same time, new lexemes have come into being that better fit the changed (and still changing) society. As a politeness strategy – both positive and negative – and a reaction to the hierarchical social structure, honorification is very much alive, in the same way its corollary notion, self-denigration, is alive. Our study hence contributes to pragmatics by drawing researchers’ attention to an important aspect of language use that has been hitherto neglected.
Gamma and Theta/Alpha-Band Oscillations in the Electroencephalogram Distinguish the Content of Inner Speech
Authors: Whitford Thomas J. , Spencer Kevin M. , Godwin Marianthe , Hirano Yoji , Chung Lawrence Kin-hei , Vodovozov Wadim , Griffiths Oren , Harris Anthony W. F. , Le Pelley Mike E. , Jack Bradley N.
Published: January 2025

Inner speech refers to the silent production of language in one’s mind. As a purely mental action without obvious physical manifestations, inner speech has been notoriously difficult to quantify. To address this issue, the present study repurposed the phenomenon of speaking-induced suppression, wherein overt speech has been consistently shown to elicit reduced auditory evoked potentials compared with externally generated speech, as well as changes in oscillatory activity in gamma and theta frequency bands. Given the functional similarities between inner and overt speech, we used an established experimental protocol to investigate whether similar metrics could be used to distinguish the content of inner speech. Healthy participants (n= 129) produced an inner syllable at a precisely specified time. An audible syllable was concurrently presented which either matched or mismatched the content of the inner syllable. The results revealed that Match and Mismatch conditions could be differentiated on the basis of their evoked oscillations in the gamma, theta, and alpha bands. Notably, there was a gamma-band oscillation in the vicinity of the P2 that differed between the Match and Mismatch conditions, suggesting that “late” gamma-band activity may index consciously perceived expectancy violations, or cognitive prediction errors. Regarding the auditory evoked potentials, the N1 component was suppressed in the Match condition while the P2 component was suppressed in the Mismatch condition, replicating previous findings. This study provides support for the existence of “inner speaking-induced suppression”, and demonstrates that inner syllables can be differentiated based on their influence on the electroencephalographic activity elicited by simultaneously-presented audible syllables.
Energy companies’ readiness for the digital transformation of the purchasing process
Authors: Kulikowska Agata , Wszendybyl-Skulska Ewa
Published: January 2025

Social and economic developments, the dynamic geopolitical situation, and climate policy
changes are exerting an increasingly significant influence on stakeholders in the energy sector.
In recent years, the sector has undergone a period of dynamic change, during which there has
been a notable increase in awareness of the potential for digital transformation within the sector.
A specific process that ensures the security and stability of supply is the purchasing process.
The objective of this article is to identify the mechanisms that facilitate and impede the digital
transformation of the purchasing process in energy companies in Poland. The research employed
a qualitative exploratory methodology based on interviews with procurement executives from Polish
energy companies. The findings of the research, together with their subsequent analysis, enabled
the identification of ten factors that act as impediments to the digital transformation of the purchasing
process in energy companies in Poland. The article puts forward five mechanisms that could
assist in overcoming the identified obstacles to transforming the purchasing process. The study
emphasizes the significance of implementing effective change management and business
digitalisation strategies to facilitate the digital transformation of purchasing process.
Differences and analogies in thyroid cancer discovered incidentally or by thyroid-related screening: a multicenter study
Authors: Croce Laura , Ruggeri Rosaria Maddalena , Virili Camilla , Cappelli Carlo , Teliti Marsida , Costa Pietro , Chytiris Spyridon , Nicocia Antonio , Coperchini Francesca , Bagaglini Maria Flavia , Magri Flavia , Campennì Alfredo , Rotondi Mario
Published: January 2025

Graphical Abstract

Objective

The prevalence of thyroid cancer (TC) has increased worldwide, and an association with metabolic and cardiovascular disorders has been reported. Moreover, an increasing percentage of patients are currently diagnosed incidentally through non-thyroid-related imaging for other clinical conditions. Our aim was to assess the prevalence of thyroid-related disease (TD) versus incidental diagnosis (ID) pre-surgery reasons leading to TC diagnosis and to compare the two groups in terms of clinical characteristics, size and severity of TC at presentation and rate of non-thyroid cancers and cardiovascular/metabolic comorbidities.

Design

We performed a retrospective cohort study in three high-volume hospital-based centers for thyroid diseases (Pavia, Latina and Messina) in Italy.

Patients

Consecutive patients with TC were included.

Measurements

Data on pre-surgery reasons leading to TC diagnosis, age, sex, BMI, presence of cardiometabolic comorbidities and non-thyroid cancer were collected.

Results

Among the 327 enrolled subjects, the diagnosis of TC was prompted by thyroid-related reasons in 262 (80.1%, TD group) and incidental in 65 (19.9%, ID group). The ID group patients were more frequently males, significantly older and with a higher BMI than the TD group ones; they had a higher rate of non-thyroidal cancers and cardiovascular/metabolic comorbidities. No significant differences could be observed in terms of TC histotype, cancer size, extrathyroidal extension, lymph node metastases, AJCC staging or American Thyroid Association (ATA) risk stratification.

Conclusions

Biological features of TC are similar in the TD and ID groups, but patients in the two groups display significant differences regarding their clinical features.
Did selective kinase inhibitors change the management of patients with radioiodine-refractory thyroid cancer?
Authors: Porcelli Tommaso , Luongo Cristina , Cerbone Anna , Di Luccio Carmine , Nacchio Mariantonia , De Stefano Maria Angela , Schlumberger Martin , Salvatore Domenico
Published: January 2025

Objective

To analyse at our institution the criteria for selecting a first-line therapy for patients with advanced radioiodine-refractory thyroid cancer and their clinical responses, safety and survival outcomes.

Patients and methods

We extracted data from 69 consecutive patients referred to Federico II University Hospital from September 2016 to September 2024, among whom 44 patients were treated with TKIs as first-line treatment and outside any clinical trial, and form the basis of this report.

Results

Thirty-one (71%) patients were treated with the antiangiogenesis inhibitor lenvatinib and 13 (29%) were treated with selective tyrosine kinase inhibitors (s-TKIs). Among the latter, eight patients were treated with dabrafenib + trametinib (DT), two patients were treated with selpercatinib because of contraindications to lenvatinib, and three patients received DT as redifferentiation therapy. A RECIST partial response was observed in 28% of patients treated with lenvatinib, in 63% of those treated with DT and in one of the two patients treated with selpercatinib. Grade ≥3 adverse events occurred in 13 (42%) patients treated with lenvatinib and only in 1 (9%) patient treated with DT. Progression-free survival (PFS) and overall survival rates at 1 year were 72% and 83% in lenvatinib-treated patients and 69% and 83% in DT-treated patients, respectively. In both selpercatinib-treated patients, the PFS at data cut-off was 10 months. No treatment-related deaths were observed.

Conclusion

S-TKIs permitted tailoring systemic treatment based on disease location, tumour volume and patient comorbidities, achieving satisfactory tolerance and outcomes in selected patients with an actionable driver mutation and with contraindications to angiogenesis inhibitors or candidates for redifferentiation therapy.
Reasonable Congruence between Charges Pressed and those Proved at Trial in Criminal Procedure Matters in Colombia According to the Adversarial System Characteristics
Authors: Daza González Alfonso , Daza Lora Santiago Andrés , Ballesteros Sánchez Julio
Published: January 2025

The congruence principle in criminal proceedings is the factual and legal correlation between the conviction and the charge. In terms of the current Colombian Code of Criminal Procedure, this correlation must occur between the counts contained in the indictment and those in the conviction and between the crimes for which a sentence is requested and those in the conviction. The problem identified in the analysis of the congruence principle in the Colombian criminal procedure lies in the possible lack of adequacy between the legislation establishing this principle and the characteristics of the adopted adversarial criminal procedural system. Through basic legal research, the characteristics of the Colombian adversarial criminal procedural system and the Supreme Court of Justice are discussed and compared with countries such as Argentina, Chile, Mexico, Puerto Rico, the United States, Germany, and Spain, identifying that the Spanish system applies to Colombia.