bluuebunny/crossref_metadata_2025 huggingface dataset:
A Sustainable and Open Access Knowledge Organization Model to Preserve Cultural Heritage and Language Diversity
Authors: Fraisse Amel , Zhang Zheng , Zhai Alex , Jenn Ronald , Fisher Fishkin Shelley , Zweigenbaum Pierre , Favier Laurence , Mustafa El Hadi Widad
Published: September 2019

This paper proposes a new collaborative and inclusive model for Knowledge Organization Systems (KOS) for sustaining cultural heritage and language diversity. It is based on contributions of end-users as well as scientific and scholarly communities from across borders, languages, nations, continents, and disciplines. It consists in collecting knowledge about all worldwide translations of one original work and sharing that data through a digital and interactive global knowledge map. Collected translations are processed in order to build multilingual parallel corpora for a large number of under-resourced languages as well as to highlight the transnational circulation of knowledge. Building such corpora is vital in preserving and expanding linguistic and traditional diversity. Our first experiment was conducted on the world-famous and well-traveled American novel Adventures of Huckleberry Finn by the American author Mark Twain. This paper reports on 10 parallel corpora that are now sentence-aligned pairs of English with Basque (an European under-resourced language), Bulgarian, Dutch, Finnish, German, Hungarian, Polish, Portuguese, Russian, and Ukrainian, processed out of 30 collected translations.
Sustainable Innovative Project Management: Response to Improve Livability and Quality of Life: Case Studies: Iran and Germany
Authors: Doost Mohammadian Hamid , Rezaie Fatemeh
Published: September 2019

Nowadays, quality of life and livability are controversial phenomenon. A high quality of life and livability are demanded in cities; however, rapid and unplanned urbanization creates a lot of challenges such as poverty, slums, social instability, insecurity, diseases, environmental challenges and climate change, unemployment, economic problems, etc., which threaten the livability of the world. Therefore, it is vital to tackle urbanization challenges and create a sustainable urban setting with a high quality of life in order to make the world a better place to live. In particular, literature reviews, surveys, exploratory case studies, and the Kiwi and Kampenhood methodology based on Persian Zarathustra that is utilized in social science, engineering and management are the main method tools in this study. Fundamentally, modern livable and sustainable urban settings are suggested as a path to deal with urbanization challenges in order to improve livability and quality of life. Although sustainable cities provide opportunities to improve quality of life, urban planning and good governance with effective regulatory frameworks to create such modern settings are required. Thus, an innovative sustainable project management is introduced as a tool to design modern livable and sustainable areas. Innovation is declared as an accelerator to achieve sustainable project management in this research.
Are CDS Spreads Sensitive to the Term Structure of the Yield Curve? A Sector-Wise Analysis under Various Market Conditions
Authors: Aman Asia
Published: September 2019

This study examines the impact of changes in the yield curve factors on the Credit Default Swap (CDS) spreads of the U.S. industrial sectors. Stock returns and the crude oil-based volatility index are used in a quantile regression framework to test the validity of Merton’s model. The results suggest that the long-term factor of the yield curve is a negatively significant determinant of the CDS premia regardless of the sector and market state. The CDS spread of the financial sector exhibits sensitivity to the short-term factor of the yield rate in extreme market states. Basic materials, oil and gas and the utilities sector are responsive to variations in the medium-term factor of the yield rate in upmarket conditions. The empirical findings also suggest a significant inverse relationship between CDS spreads and stock returns.
Continuous Preparation and Properties of Silica/Rubber Composite Using Serial Modular Mixing
Authors: Zhu Lin , Pan Yiren , Tian Xiaolong , Liu Huaqiao , Bian Huiguang , Wang Chuansheng
Published: September 2019

In order to efficiently prepare high-performance silica/rubber composites for use in the tread of semi-steel radial tires, a serial modular continuous mixer was designed according to the principle of modular functionalization. The modular structure and serial process helped control the accuracy of the silanization reaction. Synchronous four-wing serrated rotors and reverse meshing reaction mixing twin-rotors utilized shear flow and elongation flow to improve the dispersion. In this paper, the mechanism of serial modular continuous mixing was analyzed, and the influence of the core reaction mixing zone (various mixing elements) on silica-filled compounds was investigated by cooling visualization experiments, including dispersion, and the silanization reaction degree. Meanwhile, a comparative experiment between serial mixing and two-stage mixing was conducted, which showed that the serial process comprehensively improved the dispersion, mechanical properties, and dynamic mechanical properties of silica/rubber vulcanizate.
Investigation of Step-Stress Accelerated Degradation Test Strategy for Ultraviolet Light Emitting Diodes
Authors: Liang Banglong , Wang Zili , Qian Cheng , Ren Yi , Sun Bo , Yang Dezhen , Jing Zhou , Fan Jiajie
Published: September 2019

III-nitride-based ultraviolet light emitting diode (UV LED) has numerous attractive applications in air and water purification, UV photolithography, and in situ activation of drugs through optical stimulus, solid state lighting, polymer curing, and laser surgery. However, the unclear failure mechanisms and uncertainty reliability have limited its application. Therefore, a design of an appropriate reliability test plan for UV LEDs has become extremely urgent. Compared to traditional reliability tests recommended in LED lighting industry, the step-stress accelerated degradation test (SSADT) is more cost-effective and time-effective. This paper compares three SSADT testing plans with temperature and driving currents as stepwise increasing loads to determine an appropriate test strategy for UV LEDs. The study shows that: (1) the failure mechanisms among different SSADT tests seem to be very different, since the driving current determines the failure mechanisms of UV LEDs more sensitively, and (2) the stepped temperature accelerated degradation test with an appropriate current is recommended for UV LEDs.
Effect of Gypsum on Hydration and Hardening Properties of Alite Modified Calcium Sulfoaluminate Cement
Authors: Li Pei , Ma Zhiqiang , Zhang Zhong , Li Xumin , Lu Xiaolei , Hou Pengkun , Du Peng
Published: September 2019

Calcium sulphoaluminate cement (CSA) has the characteristics of quick hardening, high early strength and high impermeability, however its strength growth persistence in the middle and late stages (after the age of 3 days) is poor. In order to improve this disadvantage, the pilot production of alite (C3S) modified CSA (AMCSA) clinker was carried out by liquid phase manipulation and barium ion doping technology. The effects of different dosages of gypsum on the hydration and hardening properties of AMCSA, such as setting time, hydration rate, compressive strength and hydration products, were studied. The results show that the mineral content of ye’elimite, C2S, C3S and iron phase in the calcined AMCSA clinker are 48.5 wt.%, 32.6 wt.%, 11.7 wt.% and 7.2 wt.% respectively, which are close to the designed mineral composition. The stable coexistence of ye’elimite and C3S in the same clinker system is realized. The initial and final setting time of AMCSA are retarded with the increasing gypsum dosage. When the gypsum dosage is 15 wt.% under the experimental conditions in this study, the AMCSA mortar reaches the highest compressive strength at every age. The strength of AMCSA mortar at 28 days is still significantly improved compared with that at 3 days, which indicates that the shortcoming of the low strength growth persistence of CSA in the middle and late stages is improved.
Correction: Li, P., et al. Research on Erosion-Corrosion Rate of 304 Stainless Steel in Acidic Slurry via Experimental Design Method. Materials 2019, 12, 2330
Authors: Li Ping , Zhao Yanjie , Wang Libo
Published: September 2019

The authors wish to make the following corrections to this paper [...]
Analysis of Carbon-Based Microelectrodes for Neurochemical Sensing
Authors: Manciu Felicia S. , Oh Yoonbae , Barath Abhijeet , Rusheen Aaron E. , Kouzani Abbas Z. , Hodges Deidra , Guerrero Jose , Tomshine Jonathan , Lee Kendall H. , Bennet Kevin E.
Published: September 2019

The comprehensive microscopic, spectroscopic, and in vitro voltammetric analysis presented in this work, which builds on the well-studied properties of carbon-based materials, facilitates potential ways for improvement of carbon fiber microelectrodes (CFMs) for neuroscience applications. Investigations by both, scanning electron microscopy (SEM) and confocal Raman spectroscopy, confirm a higher degree of structural ordering for the fibers exposed to carbonization temperatures. An evident correlation is also identified between the extent of structural defects observed from SEM and Raman results with the CFM electrochemical performance for dopamine detection. To improve CFM physico-chemical surface stability and increase its mechanical resistance to the induced compressive stress during anticipated in vivo tissue penetration, successful coating of the carbon fiber with boron-doped diamond (BDD) is also performed and microspectroscopically analyzed here. The absence of spectral shifts of the diamond Raman vibrational signature verifies that the growth of an unstrained BDD thin film was achieved. Although more work needs to be done to identify optimal parameter values for improved BDD deposition, this study serves as a demonstration of foundational technology for the development of more sensitive electrochemical sensors, that may have been impractical previously for clinical applications, due to limitations in either safety or performance.
Ultrasonic Processing for Structure Refinement: An Overview of Mechanisms and Application of the Interdependence Theory
Authors: Balasubramani Nagasivamuni , StJohn David , Dargusch Matthew , Wang Gui
Published: September 2019

Research on ultrasonic treatment (UST) of aluminium, magnesium and zinc undertaken by the authors and their collaborators was stimulated by renewed interest internationally in this technology and the establishment of the ExoMet program of which The University of Queensland (UQ) was a partner. The direction for our research was driven by a desire to understand the UST parameters that need to be controlled to achieve a fine equiaxed grain structure throughout a casting. Previous work highlighted that increasing the growth restriction factor Q can lead to significant refinement when UST is applied. We extended this approach to using the Interdependence model as a framework for identifying some of the factors (e.g., solute and temperature gradient) that could be optimised in order to achieve the best refinement from UST for a range of alloy compositions. This work confirmed established knowledge on the benefits of both liquid-only treatment and the additional refinement when UST is applied during the nucleation stage of solidification. The importance of acoustic streaming, treatment time and settling of grains were revealed as critical factors in achieving a fully equiaxed structure. The Interdependence model also explained the limit to refinement obtained when nanoparticle composites are treated. This overview presents the key results and mechanisms arising from our research and considers directions for future research.
Implementation of an Algorithm to Prevent Chatter Vibration in a CNC System
Authors: Jasiewicz Marcin , Miądlicki Karol
Published: September 2019

Machining of shafts characterized by a high compliance is difficult due to the occurrence of self-excited chatter vibrations. It is possible to limit their occurrence through the appropriate selection of technological parameters. For a proper selection of these parameters it is necessary to know the dynamic properties of the machine–tool–workpiece. This study proposes an approach through which these properties can be determined as a result of the synthesis of the dynamic properties of the system, using the receptance coupling method. Knowledge of these properties allows us to select the technological parameters of the lathe using the assistance system integrated into the CNC (Computerized Numerical Control). The final section of this work presents the experimental validation of the assistant and proposed procedures.
Modeling and Characterization of a Kinetic Energy Harvesting Device Based on Galfenol
Authors: Clemente Carmine Stefano , Davino Daniele
Published: September 2019

The proposal of Energy Harvesting (EH) techniques and devices has experienced a significant growth over the last years, because of the spread of low power electronic devices. Small ambient energy quantities can be recovered through EH and exploited to power Wireless Sensor Networks (WSN) used, for example, for the Structural Health Monitoring (SHM) of bridges or viaducts. For this purpose, research on EH devices based on magnetostrictive materials has significantly grown in the last years. However, these devices comprise different parts, such as a mechanical system, magnetic circuit and electrical connections, which are coupled together. Then, a method able to reproduce the performance may be a handy tool. This paper presents a nonlinear equivalent circuit of a harvester, based on multiple rods of Galfenol, which can be solved with standard circuit simulator. The circuital parameters are identified with measurements both on one rod and on the whole device. The validation of the circuit and the analysis of the power conversion performance of the device have been conducted with different working conditions (force profile, typology of permanent magnets, resistive electrical load).
Analysis of the Elastoplastic Response in the Torsion Test Applied to a Cylindrical Sample
Authors: Toro Sebastián Andrés , Aranda Pedro Miguel , García-Herrera Claudio Moisés , Celentano Diego Javier
Published: September 2019

This work presents an experimental and numerical analysis of the mechanical behavior of a fixed-end SAE 1045 steel cylindrical specimen during the torsion test. To this end, an iterative numerical–experimental methodology is firstly proposed to assess the material response in the tensile test using a large strain elastoplasticity-based model solved in the context of the finite element method. Then, a 3D numerical simulation of the deformation process of the torsion test is tackled with this previously characterized model that proves to be able to predict the development of a high and localized triaxial stress and strain fields caused by the presence of high levels of angular deformation. Finally, the obtained numerical results are analytically studied with the cylindrical components of the Green–Lagrange strain tensor and experimentally validated with the measurements of shear strains via Digital Image Correlation (DIC) and the corresponding torque – twist angle curve.
Growth Mechanism and Properties of Self-Assembled InN Nanocolumns on Al Covered Si(111) Substrates by PA-MBE
Authors: Casallas-Moreno Y. L. , Gallardo-Hernández S. , Yee-Rendón C. M. , Ramírez-López M. , Guillén-Cervantes A. , Arias-Cerón J. S. , Huerta-Ruelas J. , Santoyo-Salazar J. , Mendoza-Álvarez J. G. , López-López M.
Published: September 2019

Self-assembled InN nanocolumns were grown at low temperatures by plasma-assisted molecular beam epitaxy with a high crystalline quality. The self-assembling procedure was carried out on AlN/Al layers on Si(111) substrates avoiding the masking process. The Al interlayer on the Si(111) substrate prevented the formation of amorphous SiN. We found that the growth mechanism at 400 ∘ C of InN nanocolumns started by a layer-layer (2D) nucleation, followed by the growth of 3D islands. This growth mechanism promoted the nanocolumn formation without strain. The nanocolumnar growth proceeded with cylindrical and conical shapes with heights between 250 and 380 nm. Detailed high-resolution transmission electron microscopy analysis showed that the InN nanocolumns have a hexagonal crystalline structure, free of dislocation and other defects. The analysis of the phonon modes also allowed us to identify the hexagonal structure of the nanocolumns. In addition, the photoluminescence spectrum showed an energy transition of 0.72 eV at 20 K for the InN nanocolumns, confirmed by photoreflectance spectroscopy.
Light Robust Goal Programming
Authors: Mensah Emmanuel Kwasi , Rocca Matteo
Published: September 2019

Robust goal programming (RGP) is an emerging field of research in decision-making problems with multiple conflicting objectives and uncertain parameters. RGP combines robust optimization (RO) with variants of goal programming techniques to achieve stable and reliable goals for previously unspecified aspiration levels of the decision-maker. The RGP model proposed in Kuchta (2004) and recently advanced in Hanks, Weir, and Lunday (2017) uses classical robust methods. The drawback of these methods is that they can produce optimal values far from the optimal value of the “nominal” problem. As a proposal for overcoming the aforementioned drawback, we propose light RGP models generalized for the budget of uncertainty and ellipsoidal uncertainty sets in the framework discussed in Schöbel (2014) and compare them with the previous RGP models. Conclusions regarding the use of different uncertainty sets for the light RGP are made. Most importantly, we discuss that the total goal deviations of the decision-maker are very much dependent on the threshold set rather than the type of uncertainty set used.
Current Research on the Bioprospection of Linear Diterpenes from Bifurcaria bifurcata: From Extraction Methodologies to Possible Applications
Authors: Pais Adriana C.S. , Saraiva Jorge A. , Rocha Sílvia M. , Silvestre Armando J.D. , Santos Sónia A.O.
Published: September 2019

Marine resources are considered as a very promising source of bioactive molecules, and macroalgae in particular have gained special attention, due to their structurally diverse composition. Particular interest has been devoted to the brown macroalga Bifurcaria bifurcata, due to their abundance in bioactive linear diterpenes. In this appraisal, a thorough review concerning the methodologies used in the extraction, fractionation, and identification of diterpenes from B. bifurcata is provided and discussed in detail. An exhaustive compilation of the mass spectra and nuclear magnetic resonance (NMR) data are also provided. The in vitro and in chemico assays already performed to assess different biological activities attributed to B. bifurcata diterpenes are also reviewed, emphasizing the use of isolated components, enriched fractions, or crude extracts. The associated major strengths and challenges for the exploitation of B. bifurcata diterpenes for high-value applications are critically discussed.
Bioactive Peptides Produced by Cyanobacteria of the Genus Nostoc: A Review
Authors: Fidor Anna , Konkel Robert , Mazur-Marzec Hanna
Published: September 2019

Cyanobacteria of the genus Nostoc are widespread in all kinds of habitats. They occur in a free-living state or in association with other organisms. Members of this genus belong to prolific producers of bioactive metabolites, some of which have been recognized as potential therapeutic agents. Of these, peptides and peptide-like structures show the most promising properties and are of a particular interest for both research laboratories and pharmaceutical companies. Nostoc is a sole source of some lead compounds such as cytotoxic cryptophycins, antiviral cyanovirin-N, or the antitoxic nostocyclopeptides. Nostoc also produces the same bioactive peptides as other cyanobacterial genera, but they frequently have some unique modifications in the structure. This includes hepatotoxic microcystins and potent proteases inhibitors such as cyanopeptolins, anabaenopeptins, and microginins. In this review, we described the most studied peptides produced by Nostoc, focusing especially on the structure, the activity, and a potential application of the compounds.
Epidemiology, Risk Factors and Measures for Preventing Drowning in Africa: A Systematic Review
Authors: Miller Lauren , Alele Faith , Emeto Theophilus , Franklin Richard
Published: September 2019

Background and Objectives: Drowning is a leading cause of unintentional injury related mortality worldwide, and accounts for roughly 320,000 deaths yearly. Over 90% of these deaths occur in low- and middle-income countries with inadequate prevention measures. The highest rates of drowning are observed in Africa. The aim of this review is to describe the epidemiology of drowning and identify the risk factors and strategies for prevention of drowning in Africa. Materials and Methods: A review of multiple databases (MEDLINE, CINAHL, PsycINFO, Scopus and Emcare) was conducted from inception of the databases to the 1st of April 2019 to identify studies investigating drowning in Africa. The preferred reporting items for systematic review and meta-analysis (PRISMA) was utilised. Results: Forty-two articles from 15 countries were included. Twelve articles explored drowning, while in 30 articles, drowning was reported as part of a wider study. The data sources were coronial, central registry, hospital record, sea rescue and self-generated data. Measures used to describe drowning were proportions and rates. There was a huge variation in the proportion and incidence rate of drowning reported by the studies included in the review. The potential risk factors for drowning included young age, male gender, ethnicity, alcohol, access to bodies of water, age and carrying capacity of the boat, weather and summer season. No study evaluated prevention strategies, however, strategies proposed were education, increased supervision and community awareness. Conclusions: There is a need to address the high rate of drowning in Africa. Good epidemiological studies across all African countries are needed to describe the patterns of drowning and understand risk factors. Further research is needed to investigate the risk factors and to evaluate prevention strategies.
Rational Suicide in Late Life: A Systematic Review of the Literature
Authors: Gramaglia Carla , Calati Raffaella , Zeppegno Patrizia
Published: September 2019

Background and Objectives: The complex concept of rational suicide, defined as a well-thought-out decision to die by an individual who is mentally competent, is even more controversial in the case of older adults. Materials and Methods: With the aim of better understanding the concept of rational suicide in older adults, we performed a systematic review of the literature, searching PubMed and Scopus databases and eventually including 23 published studies. Results: The main related topics emerging from the papers were: depression, self-determination, mental competence; physicians’ and population’s perspectives; approach to rational suicide; ageism; slippery slope. Conclusions: Despite contrasting positions and inconsistencies of the studies, the need to carefully investigate and address the expression of suicidal thoughts in older adults, as well as behaviours suggesting “silent” suicidal attitudes, clearly emerges, even in those situations where there is no diagnosable mental disorder. While premature conclusions about the “rationality” of patients’ decision to die should be avoided, the possibility of rational suicide cannot be precluded.
Association of Kidney Function Tests with a Cardio-Ankle Vascular Index in Community-Dwelling Individuals with a Normal or Mildly Decreased Estimated Glomerular Filtration Rate
Authors: Alizargar Javad , Bai Chyi-Huey , Hsieh Nan-Chen , Wu Shu-Fang Vivienne , Weng Shih-Yen , Wu Jia-Ping
Published: September 2019

Background and objectives: Chronic kidney disease (CKD) is an independent risk factor for cardiovascular disease (CVD). Previous studies reported controversial results about the independence of CKD as a risk factor for atherosclerosis. In this study, we tried to determine whether the estimated glomerular filtration rate (eGFR) and other renal function tests are independent factors associated with arterial stiffness in community-dwelling individuals with a normal (≥90) or slightly decreased eGFR (60-90). Materials and Methods: Data of 164 community individuals were analyzed, and demographic information, related disease history, atherosclerosis risk factors, certain laboratory tests, the estimated eGFR, and urine albumin creatinine ratio (UACR) were recorded for each individual. Results: The age, systolic blood pressure (SBP), hypertension (HTN), and cardio-ankle vascular index (CAVI) significantly differed between individuals with a normal and those with a slightly decreased eGFR. Blood urea nitrogen (BUN), glycated hemoglobin (HBA1c), and the eGFR significantly differed between the high- and low-CAVI groups and were also significantly correlated with the CAVI. The relationship between the eGFR and CAVI was shown to be independent of other atherosclerosis risk factors in a multiple linear regression model. Conclusions: We concluded that evaluations of the eGFR, HTN, body-mass index, and SBP can be used in a model for arterial stiffness risk assessments for community-dwelling individuals with a normal or slightly decreased eGFR.
Rehabilitation Program Combined with Local Vibroacoustics Improves Psychophysiological Conditions in Patients with ACL Reconstruction
Authors: Park Jung-Min , Park Sihwa , Jee Yong-Seok
Published: September 2019

Background and objective: This study investigated the therapeutic effect of applying local body vibration (LBV) with built-in vibroacoustic sound on patients who had an anterior cruciate ligament (ACL) reconstruction. Materials and Methods: Twenty-four participants were randomly classified into a LBV group (LBVG; n = 11) or a non-LBV group (nLBVG; n = 13). Both groups received the same program; however, the LBVG received LBV. Psychological measures included pain, anxiety, and symptoms; physiological measures included systolic blood pressure (SBP), diastolic blood pressure, heart rate (HR), breathing rate (BR), sympathetic activation (SA), parasympathetic activation (PSA), range of motion (ROM), and isokinetic muscle strength at Weeks 0, 4, and 8. Results: Among the psychophysiological variables, pain, anxiety, symptoms, SBP, BR, and SA were significantly reduced in both groups, whereas HR, PSA, isokinetic peak torque (PT) of the knee joint, and ROM were significantly improved only in the LBVG. Comparing both groups, a significant difference appeared in pain, symptom, SA, PSA, isokinetic PT, and ROM at Weeks 4 and 8. Conclusions: The results indicate that the LBV intervention mitigated the participants’ pain and symptoms and improved their leg strength and ROM, thus highlighting its effectiveness.
An Introduction to Wear Degradation Mechanisms of Surface-Protected Metallic Components
Authors: Psyllaki Pandora P.
Published: September 2019

Despite the fact that ceramics and polymers have found numerous applications in several mechanical systems, metals and metallic alloys still remain the main materials family for manufacturing the bulk of parts and components of engineering assemblies. However, in cases of components that are serving as parts of a tribosystem, the application of surface modification techniques is required to ensure their unhampered function during operation. After a short introduction on fundamental aspects of tribology, this review article delves further into four representative case studies, where the inappropriate application of wear protection techniques has led to acceleration of the degradation of the quasi-protected metallic material. The first deals with the effects of the deficient lubrication of rolling bearings designed to function under oil lubrication conditions; the second is focused on the effects of overloading on sliding bearing surfaces, wear-protected via nitrocarburizing; the third concerns the application of welding techniques for producing hardfacing overlayers intended for the wear protection of heavily loaded, non-lubricated surfaces; the fourth deals with the degradation of thermal-sprayed ceramic coatings, commonly used as wear-resistant layers.
Placenta, Pericarp, and Seeds of Tabasco Chili Pepper Fruits Show a Contrasting Diversity of Bioactive Metabolites
Authors: Cervantes-Hernández Felipe , Alcalá-González Paul , Martínez Octavio , Ordaz-Ortiz José Juan
Published: September 2019

Chili pepper (Capsicum spp.) is one of the most important horticultural crops worldwide, and its unique organoleptic properties and health benefits have been established for centuries. However, there is little knowledge about how metabolites are distributed throughout fruit parts. This work focuses on the use of liquid chromatography coupled with high resolution mass spectrometry (UHPLC-ESI-HRMS) to estimate the global metabolite profiles of the pericarp, placenta, and seeds of Tabasco pepper fruits (Capsicum frutescens L.) at the red mature stage of ripening. Our main results putatively identified 60 differential compounds between these tissues and seeds. Firstly, we found that pericarp has a higher content of glycosides, showing on average a fold change of 5 and a fold change of 14 for terpenoids when compared with other parts of the fruit. While placenta was the richest tissue in capsaicinoid-related compounds, alkaloids, and tocopherols, with a 35, 3, and 7 fold change, respectively. However, the seeds were richer in fatty acids and saponins with fold changes of 86 and 224, respectively. Therefore, our study demonstrates that a non-targeted metabolomic approach may help to improve our understanding of unexplored areas of plant metabolism and also may be the starting point for a detailed analysis in complex plant parts, such as fruits.
Improved Memory Properties of Graphene Oxide-Based Organic Memory Transistors
Authors: Al-shawi Amjad , Alias Maysoon , Sayers Paul , Mabrook Mohammed Fadhil
Published: September 2019

To investigate the behaviour of the organic memory transistors, graphene oxide (GO) was utilized as the floating gate in 6,13-Bis(triisopropylsilylethynyl)pentacene (TIPS-pentacene)-based organic memory transistors. A cross-linked, off-centre spin-coated and ozone-treated poly(methyl methacrylate) (cPMMA) was used as the insulating layer. High mobility and negligible hysteresis with very clear transistor behaviour were observed for the control transistors. On the other hand, memory transistors exhibited clear large hysteresis which is increased with increasing programming voltage. The shifts in the threshold voltage of the transfer characteristics as well as the hysteresis in the output characteristics were attributed to the charging and discharging of the floating gate. The counter-clockwise direction of hysteresis indicates that the process of charging and discharging the floating gate take place through the semiconductor/insulator interface. A clear shift in the threshold voltage was observed when different voltage pulses were applied to the gate. The non-volatile behaviour of the memory transistors was investigated in terms of charge retention. The memory transistors exhibited a large memory window (~30 V), and high charge density of (9.15 × 1011 cm−2).
A Novel Button-Type Micro Direct Methanol Fuel Cell with Graphene Diffusion Layer
Authors: Zhu Yingli , Gao Lei , Li Jianyu
Published: September 2019

In order to solve the problem that bolts in traditional packaged direct methanol fuel cells (DMFCs) take up a large area and reduce the specific energy (energy per unit weight) and power density (power per unit area), a new button-type micro direct methanol fuel cell (B-μDMFC) is designed, assembled, and packaged. The cell with four different structures was tested before and after packaging. The results indicate that the button cell with three-dimensional graphene and springs has the best performance. The equivalent circuit and methanol diffusion model was applied to explain the experimental results. The peak volumetric specific power density of the cell is 11.85 mW cm−3. This is much higher than traditional packaged DMFC, because the novel B-μDMFC eliminates bolts in the structure and improves the effective area ratio of the cell.
Improvements of Microcontact Printing for Micropatterned Cell Growth by Contrast Enhancement
Authors: Hondrich Timm J. J. , Deußen Oliver , Grannemann Caroline , Brinkmann Dominik , Offenhäusser Andreas
Published: September 2019

Patterned neuronal cell cultures are important tools for investigating neuronal signal integration, network function, and cell–substrate interactions. Because of the variable nature of neuronal cells, the widely used coating method of microcontact printing is in constant need of improvements and adaptations depending on the pattern, cell type, and coating solutions available for a certain experimental system. In this work, we report on three approaches to modify microcontact printing on borosilicate glass surfaces, which we evaluate with contact angle measurements and by determining the quality of patterned neuronal growth. Although background toxification with manganese salt does not result in the desired pattern enhancement, a simple heat treatment of the glass substrates leads to improved background hydrophobicity and therefore neuronal patterning. Thirdly, we extended a microcontact printing process based on covalently linking the glass surface and the coating molecule via an epoxysilane. This extension is an additional hydrophobization step with dodecylamine. We demonstrate that shelf life of the silanized glass is at least 22 weeks, leading to consistently reliable neuronal patterning by microcontact printing. Thus, we compared three practical additions to microcontact printing, two of which can easily be implemented into a workflow for the investigation of patterned neuronal networks.
Stretchable Piezoelectric Power Generators Based on ZnO Thin Films on Elastic Substrates
Authors: Voiculescu Ioana , Li Fang , Kowach Glen , Lee Kun-Lin , Mistou Nicolas , Kastberg Russell
Published: September 2019

The paper describes a stretchable, microfabricated power generator that will be attached on the skin and will produce energy based on the movements of the human body. The device was fabricated on a polymeric, elastomeric, poly(dimethylsiloxane) (PDMS) sheet. It consists of a piezoelectric thin film of ZnO sandwiched between two stretchable gold electrodes. An innovative technique was used for the deposition of ZnO thin film on the gold electrode-coated polymeric substrate at low temperatures below 150 °C. This is the first attempt to use a uniform film of ZnO, for energy harvesting. The ZnO film had the thickness at the submicron scale and the surface at the centimeter scale. We demonstrated that under a strain of 8% the voltage output from this power generator was equal to 2 V, the power output was equal to 160 μW and the corresponding power density was 1.27 mW/cm2. This device has great potential for application in power sensors attached on the human body, such as temperature sensors or wearable electrocardiography systems.
A Comparison of Mineralogical and Thermal Storage Characteristics for Two Types of Stone Coal
Authors: Li Chuanchang , Ma Huan , Xie Baoshan , Zhang Bo , Zhao Xinbo , Wang Mengfan , He Zhangxing , Li Wei , Chen Jian
Published: September 2019

Understanding the mineralogical and chemical characteristics of stone coal is imperative for exploring the thermal storage characteristics of stone coal. Two types stone coal (SCwt and SChc) were sampled from the pond of a stone coal mine in Henan province (China), and the chemical composition, phase composition, and thermal behavior of the stone coal were investigated. Furthermore, the petrography of the stone coal was studied in detail. The mineral phases of the stone coal were quartz, kaolinite, roscoelite, and goethite, as distinguished by reflected light microscopy and further proven by scanning electron microscope-energy dispersive spectrometer (SEM-EDS). The thermal conductivity of SCwt was 0.19 W m−1 K−1, while that of SChc was 0.24 W m−1 K−1. Stearic acid (SA) was blended with SCwt and SChc to prepare SA/SCwt and SA/SChc composites via an impregnation method, respectively. The thermogravimetric (TG) curves show that the loading capacity of SChc, at 17.40%, is higher than that of SCwt (16.63%). The thermal energy storage capacities of SA/SCwt and SA/SChc composites were 29.21 J g−1 and 33.02 J g−1 according to a differential scanning calorimetry (DSC) analysis. Therefore, SChc is a potential candidate for thermal storage applications due to more obvious thermal storage characteristics, including higher thermal conductivity and loading capacity.
Mesozoic Northward Subduction Along the SE Asian Continental Margin Inferred from Magmatic Records in the South China Sea
Authors: Cai Guanqiang , Wan Zhifeng , Yao Yongjian , Zhong Lifeng , Zheng Hao , Kapsiotis Argyrios , Zhang Cheng
Published: September 2019

During the Mesozoic, Southeast (SE) Asia (including South China and the South China Sea (SCS)) was located in a transitional area between the Tethyan and Pacific geotectonic regimes. However, it is unclear whether geodynamic processes in the SE Asian continental margin were controlled by Tethyan or paleo-Pacific Ocean subduction. Herein, we report ~124 Ma adakitic granodiorites and Nb-enriched basalts from the Xiaozhenzhu Seamount of the SCS. Granodiorites have relatively high Sr/Y (34.7–37.0) and (La/Yb)N (13.8–15.7) ratios, as well as low Y (9.67–9.90 μg/g) and Yb (0.93–0.94 μg/g) concentrations, typical of adakites. Their Sr/Y and (La/Yb)N values coupled with their relatively low initial 87Sr/86Sr ratios (0.70541–0.70551), relatively high K2O contents (3.31–3.38 wt%), high Th/La ratios (0.33–0.40), negative εNd(t) values (−3.62 to −3.52), and their variable zircon εHf(t) values (−3.8 to +5.2) indicate that these rocks were formed by melting of subducted oceanic crust and sediments. The Nb-enriched basalts show enrichment in high field strength elements (HFSE) and have εNd(t) values of +2.90 to +2.93, as well as relatively low initial 87Sr/86Sr ratios of 0.70341–0.70343, demonstrating that they were derived from a depleted-mantle (DM) source metasomatized by silicate magmas originating from melting of a subducted oceanic lithospheric slab. By combining our findings with data from other Late Mesozoic arc-related magmatic rocks and adakites from the broader study area, we propose a geotectonic model involving subduction of young oceanic lithosphere during the Late Jurassic and northward subduction of the proto-South China Sea (PSCS) along the SE Asian continental margin during the Early Cretaceous. This conceptual model better explains the two-period Mesozoic magmatism, commonly reported for the SE Asian continental margin.
Evolution of the Upper Yellow River as Revealed by Changes in Heavy-Mineral and Geochemical (REE) Signatures of Fluvial Terraces (Lanzhou, China)
Authors: Wang Zhao , Zhang Haobo , Garzanti Eduardo , Nie Junsheng , Peng Wenbin , Andò Sergio , Hu Xiaofei , Pan Baotian , Pfaff Katharina
Published: September 2019

Despite decades of study, the factors that controlled the formation and evolution of the upper reaches of the Yellow River, including uplift of the northeastern Tibetan Plateau, Pliocene-Pleistocene climate change, and autogenetic processes are still poorly constrained. The stratigraphic record of such paleogeographic evolution is recorded in the sequence of nine terraces formed during progressive incision of the Yellow River in the last 1.7 Ma. This article investigates in detail for sediment provenance in terraces of the Lanzhou area, based on heavy-mineral and geochemical (REE) signatures. Two main provenance changes are identified, pointing each to a major paleogeographic reorganization coupled with expansion of the upper Yellow River catchment and enhanced sediment fluxes. The first change took place between the deposition of terrace T9 (formed around 1.7 Ma) and terrace T8 (formed around 1.5 Ma), when rapid fluvial incision point to tectonic control and active uplift of northeastern Tibetan Plateau. The second change took place between deposition of terrace T4 (formed around 0.86 Ma) and terrace T3 (formed around 0.14 Ma), during a period of low incision rates and notably enhanced sediment fluxes as a response to enhanced East Asian Summer Monsoon and consequently increased precipitations, pointing instead chiefly to climatic control.
Chemoenzymatic Total Synthesis of (+)-10-Keto-Oxycodone from Phenethyl Acetate
Authors: Endoma-Arias Mary , Dela Paz Helen , Hudlicky Tomas
Published: September 2019

The total synthesis of (+)-10-keto-oxycodone was attained from phenethyl acetate in a stereoselective manner. Absolute stereochemistry was established via enzymatic dihydroxylation of phenethyl acetate with the recombinant strain JM109 (pDTG601A) that furnished the corresponding cis-cyclohexadienediol whose configuration corresponds to the absolute stereochemistry of the ring C of (+)-10-keto-oxycodone. Intramolecular Heck reaction was utilized to establish the quaternary carbon at C-13, along with the dibenzodihydrofuran functionality. The C-14 hydroxyl and C-10 ketone were installed via SmI2-mediated radical cyclization, and oxidation of a benzylic alcohol (obtained from an intermediate nitrate azide), respectively. The synthesis of (+)-10-keto-oxycodone was completed in a total of 14 operations (21 steps) and an overall yield of ~2%. Experimental and spectral data are provided for key intermediates and new compounds.
Inuloxin E, a New Seco-Eudesmanolide Isolated from Dittrichia viscosa, Stimulating Orobanche cumana Seed Germination
Authors: Masi Marco , Fernández-Aparicio Mónica , Zatout Roukia , Boari Angela , Cimmino Alessio , Evidente Antonio
Published: September 2019

A new sesquiterpenoid belonging to the subgroup seco-eudesmanolides and named inuloxin E was isolated from Dittrichia viscosa, together with the already known sesquiterpenoids inuloxins A–D and α-costic acid. Inuloxin E was characterized by spectroscopic data (essentially NMR and ESI MS) as 3-methylene-6-(1-methyl-4-oxo-pentyl)-3a,4,7,7a-tetrahydro-3H-benzofuran-2-one. Its relative configuration was determined by comparison with the closely related inuloxin D and chemical conversion of inuloxin E into inuloxin D and by the observed significant correlation in the NOESY spectrum. Both inuloxins D and E induced germination of the parasitic weed Orobanche cumana, but were inactive on the seeds of Orobanche minor and Phelipanche ramosa. The germination activity of some hemisynthetic esters of inuloxin D was also investigated.
Root Bark of Paeonia suffruticosa Extract and Its Component Methyl Gallate Possess Peroxynitrite Scavenging Activity and Anti-Inflammatory Properties through NF-κB Inhibition in LPS-treated Mice
Authors: Park Dong , Jung Hee , Park Chan , Yokozawa Takako , Jeong Ji-Cheon
Published: September 2019

A peroxynitrite (ONOO−)-generating system induced by 3-morpholinosydnonimine, was used to evaluate the ONOO− scavenging properties of plants that have been widely used as traditional medicine in Korea for the treatment of several diseases. The most effective medicinal plants were Paeonia suffruticosa Andrew, followed in order by Lonicera japonica Thunb., Curcuma zedoaria (Christm.) Roscoe, and Pueraria thunbergiana Benth. In addition, root bark of P. suffruticosa was partitioned with organic solvents of different polarities, and the ethyl acetate (EtOAc) fraction showed the strongest ONOO− scavenging activity. Methyl gallate, a plant-derived phenolic compound identified from the EtOAc fraction, exerted strong ONOO− scavenging activity. The in vivo therapeutic potential of methyl gallate was investigated using lipopolysaccharide-treated mice. Oral administration of methyl gallate protected against acute renal injury and exhibited potential anti-inflammatory properties through an increase in antioxidant activity and decrease in nuclear factor-kappa B activity.
Fermentation by Multiple Bacterial Strains Improves the Production of Bioactive Compounds and Antioxidant Activity of Goji Juice
Authors: Liu Yuxuan , Cheng Huan , Liu Huiyan , Ma Ruoshuang , Ma Jiangtao , Fang Haitian
Published: September 2019

Microorganisms can be used for enhancing flavors or metabolizing functional compounds. The fermented-food-derived bacterial strains comprising Bacillus velezensis, Bacillus licheniformis, and Lactobacillus reuteri mixed with Lactobacillus rhamnosus and Lactobacillus plantarum were used to ferment goji berry (Lycium barbarum L.) juice in this study. The fermentation abilities and antioxidant capacities of different mixtures of multiple strains in goji juice were compared. The results showed that the lactic acid contents increased 9.24–16.69 times from 25.30 ± 0.71 mg/100 mL in goji juice fermented using the SLV (Lactobacillus rhamnosus, Lactobacillus reuteri, and Bacillus velezensis), SZP (Lactobacillus rhamnosus, Lactobacillus plantarum, and Bacillus licheniformis), and SZVP (Lactobacillus rhamnosus, Lactobacillus plantarum, Bacillus velezensis, and Bacillus licheniformis) mixtures, and the protein contents increased 1.31–2.11 times from 39.23 ± 0.67 mg/100 mL. In addition, their contents of volatile compounds increased with positive effects on aroma in the fermented juices. Conversion of the free and bound forms of phenolic acids and flavonoids in juice was influenced by fermentation, and the antioxidant capacity improved significantly. Fermentation enhanced the contents of lactic acid, proteins, volatile compounds, and phenols. The antioxidant capacity was strongly correlated with the phenolic composition.
Validation of Cell-Based Assay for Quantification of Sesamol Uptake and Its Application for Measuring Target Exposure
Authors: Srisongkram Tarapong , Weerapreeyakul Natthida
Published: September 2019

The intracellular drug concentration is needed for determination of target exposure at the site of action regarding its pharmacological action and adverse effects. Sesamol is an antiproliferative molecule from Sesamum indicum with promising health benefits. We present a method for measuring the intracellular sesamol content using reverse-phase HPLC with a UV diode array in melanoma cells. Sesamol was completely resolved by isocratic elution (4.152 ± 0.008 min) with methanol/water (70%, v/v) through a 30 °C, 5-µm C-18 column and detection at 297 nm. The present assay offers high sensitivity, fast elution, and an accurate and linear nominal concentration range of 10–1000 ng/mL (R2 = 0.9972). The % accuracy of the sesamol quality control sample was −3.36% to 1.50% (bias) with a 0.84% to 5.28% relative standard deviation (RSD), representing high repeatability and high reproducibility. The % recovery was 94.80% to 99.29%, which determined that there was no loss of sesamol content during the sample preparation. The validated method was applied to monitor intracellular sesamol concentration after treatment from 5 min to 24 h. The remaining intracellular sesamol content was correlated with its antiproliferative effect (R2 = 0.9483). In conclusion, this assay demonstrated low manipulation, quick elution, and high sensitivity, precision, accuracy, and recovery, and it was successfully applied to the quantification of sesamol in target cells.