bluuebunny/crossref_metadata_2025 huggingface dataset:
Prenatal diagnosis of two different unbalanced forms of an inherited (Y;12) translocation
Authors: Mademont‐Soler Irene , Morales Carme , Madrigal Irene , Margarit Ester , Bruguera Jordi , Clusellas Núria , Martínez José M. , Borrell Antoni , Sánchez Aurora , Soler Anna
Published: November 2009

The identification of an unexpected structural chromosome rearrangement at prenatal diagnosis can be problematic and raises unique genetic counseling issues. We describe two consecutive prenatal cases within a family with an inherited unbalanced (Y;12) translocation and discuss the genotype–phenotype correlation. The first fetus presented with 12qter monosomy and pseudoautosomal region 2 trisomy, while the second fetus had the alternative unbalanced state. Although the first fetus had a structural heart defect, such small imbalances might not give sonographic findings, making their prenatal diagnosis difficult. However, congenital abnormalities are expected in both unbalanced forms of the translocation, including mental retardation, which could be explained by the gene dosage variation of P2RX2. To our knowledge, these are the first published cases reporting this subtype of (Y;12) translocation, in both balanced and unbalanced states. © 2009 Wiley‐Liss, Inc.
Down syndrome: Comments and reflections on the 50th anniversary of Lejeune's discovery
Authors: Neri Giovanni , Opitz John M.
Published: November 2009

Over the past some 160 years, the study of Down syndrome (DS) went from early efforts of differentiating it from cretinism (Séguin) to its establishment as a specific nosologic category of mental deficiency (Down) and subsequent attempts to infer its cause. DS was known to be an overwhelmingly sporadic disorder, concordant in MZ and discordant in DZ twins and associated with increased maternal reproductive age (Penrose). Beginning in the 1920s and based in part on phenotype analysis and early cytogenetic insights in Drosophilia, several clinicians (Halbertsma, Waardenburg, Bleyer, Fanconi) and the geneticist C.B. Davenport postulated that DS might be due to a chromosome abnormality; only Davenport, with T.S. Painter, made an actual attempt to perform a clinical/cytological study (with inconclusive results). It was only with the application of the methods of Belling (colchicine, squash preparations) and of T.C. Hsu (hypotonic solution) to PHA‐treated cell cultures in the mid‐late 1950s, that it became possible to study, accurately, the human karyotype and its aberrations, allowing Lejeune et al. and Jacobs et al. in 1959 to discover the cause of DS. Nowadays, aided with powerful molecular methods, it has become possible to attain insights into the pathogenesis of DS based on the study of many duplications/deficiencies of HSA21 in humans and ingeniously constructed cytogenetic rearrangements of MMA16 in the mouse. These suggest a complex epigenetic interaction between genes on HSA21 and many (?most) other genes in the human genome, akin to an attempt at speciation as suggested early during the last century by Blakesly in his work on Datura. Many important ongoing efforts are underway in several countries to understand the developmental biology of DS, offering hope of ultimate amelioration for those averse to pregnancy termination. © 2009 Wiley‐Liss, Inc.
Ontogeny and phyletic size change in living and fossil lemurs
Authors: Ravosa Matthew J. , Daniel Ashley N.
Published: November 2009

Lemurs are notable for encompassing the range of body‐size variation for all primates past and present—close to four orders of magnitude. Benefiting from the phylogenetic proximity of subfossil lemurs to smaller‐bodied living forms, we employ allometric data from the skull to probe the ontogenetic bases of size differentiation and morphological diversity across these clades. Building upon prior pairwise comparisons between sister taxa, we performed the first clade‐wide analyses of craniomandibular growth allometries in 359 specimens from 10 lemuroids and 176 specimens from 8 indrioids. Ontogenetic trajectories for extant forms were used as a criterion of subtraction to evaluate morphological variation, and putative adaptations among sister taxa. In other words, do species‐level differences in skull form result from the differential extension of common patterns of relative growth?

In lemuroids, a pervasive pattern of ontogenetic scaling is observed for facial dimensions in all genera, with three genera also sharing relative growth trajectories for jaw proportions (Lemur, Eulemur, Varecia). Differences in masticatory growth and form characterizing Hapalemur and fossil Pachylemur likely reflect dietary factors. Pervasive ontogenetic scaling characterizes the facial skull in extant Indri, Avahi, and Propithecus, as well as their larger, extinct sister taxa Mesopropithecus and Babakotia. Significant interspecific differences are observed in the allometry of indrioid masticatory proportions, with variation in the mechanical advantage of the jaw adductors and stress‐resisting elements correlated with diet. As the growth series and adult data are largely coincidental in each clade, interspecific variation in facial form may result from selection for body‐size differentiation among sister taxa. Those cases where trajectories are discordant identify potential dietary adaptations linked to variation in masticatory forces during chewing and biting. Although such dissociations highlight selection to uncouple shared ancestral growth patterns, they occur largely via transpositions and retention of primitive size‐shape covariation patterns or relative growth coefficients. Am. J. Primatol. 72:161–172, 2010. © 2009 Wiley‐Liss, Inc.
Synthesis and Biological Evaluation of Novel 5,8‐Disubstituted‐2‐methyl‐2,3,4,5‐tetrahydro‐1H‐pyrido[4,3‐b] indoles as 5‐HT6and H1Receptors Antagonists
Authors: Ivachtchenko Alexandre V. , Frolov Eugene B. , Mitkin Oleg D. , Kysil Volodymyr M. , Khvat Alexander V. , Tkachenko Sergey E.
Published: November 2009

Synthesis, biological evaluation, and structure‐activity relationships (SAR) for a series of novel γ‐carboline analogues of Dimebon are described. Among the studied compounds, tetrahydro‐γ‐carboline5b(2,8‐dimethyl‐5‐[cis‐2‐pyridin‐3‐ylvinyl]‐2,3,4,5‐tetrahydro‐carboline) has been identified as the most potent small molecule antagonist, in particular against histamine H1and serotonin 5‐HT6receptors (IC50< 0.45 μM and IC50= 0.73 μM, respectively). A thorough comparative SAR study performed for the tested compounds has revealed significant correlations between the nature of side substituents and the related antagonistic activity.
Arylazoamidoximes and Related Compounds as NO‐modulators
Authors: Schröder Alexander , Kotthaus Jürke , Schade Dennis , Clement Bernd , Rehse Klaus
Published: November 2009

Three amidinoarylhydrazines 1, three arylazoamidines 2, and nine arylazoamidoximes 3 have been synthesized and investigated for their potential to function as nitric oxide (NO) modulators. In‐vitro studies demonstrated that 2 and 3 inhibited platelet aggregation (2c, IC50 = 3 μM) which could also be shown in vivo by inhibition of thrombus formation in arterioles (3a, 22%). Moreover, for all compounds antihypertensive effects were examined in vivo with SHR rats, with 2a being the most potent candidate by lowering blood pressure by 19%. However, no common underlying mechanism of action could be shown. Some of these compounds released HNO non‐enzymatically. Incubations with NO synthase isoforms (NOSs) revealed, that compounds 1 to 3 were weak substrates for NOSs but arylazoamidoximes 3 remarkably elevated the NOSs activity in the presence of L‐arginine (3h, up to fivefold). In addition, we examined effects on arginase and dimethylarginine dimethylaminohydrolase (DDAH), two further enzymes involved in the complex regulation of NO biosynthesis, to elucidate whether the observed in‐vivo effects can be traced back to their modulation. Furthermore, the metabolic fate of arylazoamidoximes 3 was addressed by investigation of a possible N‐reductive biotransformation. In summary, novel NO‐modulating compound classes are presented, among which arylazoamidoximes 3 are potent activators of NOS isoforms, and arylazoamidines 2 exert in‐vivo effects by unknown mechanisms.
Knowledge diffusion through publications and citations: A case study using ESI‐fields as unit of diffusion
Authors: Liu Yuxian , Rousseau Ronald
Published: November 2009

Two forms of diffusion are studied: diffusion by publications, originating from the fact that a group publishes in different fields; and diffusion by citations, originating from the fact that the group's publications are cited in different fields. The first form of diffusion originates from an internal mechanism by which the group itself expands its own borders. The second form is partly driven by an external mechanism, in the sense that other fields use or become interested in the original group's expertise, and partly by the group's internal dynamism, in the sense that their articles, being published in more and more fields, have the potential to be applied in these other fields. In this contribution, we focus on basic counting measures as measures of diffusion. We introduce the notions of field diffusion breadth, defined as the number of for Essential Science Indicators (ESI) fields in which a set of articles is cited, and field diffusion intensity, defined as the number of citing articles in one particular ESI field. Combined effects of publications and citations can be measured by the Gini evenness measure. Our approach is illustrated by a study of mathematics at Tongji University (Shanghai, China).
Schienenlängskräfte auf Brücken bei Zugüberfahrt
Authors: Ruge Peter , Widarda Dina Rubiana , Birk Carolin
Published: November 2009

Dieser Beitrag gilt dem Problemkreis “Abtragung von Längskräften auf Eisenbahnbrücken mit durchgehend geschweißtem Gleis”. Im Mittelpunkt stehen dabei die zusätzlichen Beanspruchungen zu den jahreszeitlichen Temperaturveränderungen, die sich bei der Zugüberfahrt infolge des Steifigkeitswechsels der Kopplung zwischen Gleis und Brückentragwerk ergeben. Dieses Phänomen wird zunächst an einem einfachen Ersatzsystem mit zwei Freiheitsgraden beschrieben und rechnerisch dargestellt.

Statische und dynamische Parameterstudien an einem realitätsnäheren Gleis‐Tragwerk‐Modell zeigen die Entwicklung der Schienenlängsspannungen und horizontalen Brückenauflagerkraft für die Lastfolge jahreszeitlicher Temperaturwechsel – Biegung des Tragwerks – Wechsel der Koppelsteifigkeit unter Einbeziehung der Verformungsgeschichte.

Longitudinal rail forces on railway bridges during passing of trains.

This paper is devoted to the field of longitudinal forces on railway bridges with continuously welded rails. Here, the focus is placed on stresses additional to those from seasonal temperature change due to the sudden change of the coupling stiffness between track and bridge when a train is running along the bridge. This phenomenon is first explained and realized numerically by means of a simplified two degree of freedom system.

Parameter studies, statically as well as dynamically, for a more realistic track‐bridge model demonstrate the development of the longitudinal rail stresses and the horizontal bridge‐support forces for the loading sequence seasonal temperature change – bending of the bridge – change of coupling stiffness with paying attention to the deformation history.
Der Ausbau des Mittleren Rings Ost in München
Authors: Wurzer Otto , Wulf Ralf , Scholz Ulrich
Published: November 2009

Der Ausbau des Mittleren Rings Ost stellt eine bedeutende Infrastrukturmaßnahme für den Ostteil der Landeshauptstadt München dar, die vor allem auf die Verbesserung des Verkehrsflusses und die Reduktion der Schall‐ und Schadstoffimmissionen am hochbelasteten Mittleren Ring ausgerichtet ist. Auch weitreichende städtebauliche Maßnahmen können nach Abschluss der Tunnelbauarbeiten an der Oberfläche realisiert werden. Der Beitrag befasst sich sowohl mit dem Verkehrskonzept der Ausbaumaßnahme wie auch mit Bemessung, Konstruktion und Bauausführung der zugehörigen Tunnelbauwerke. Ein Schwerpunkt der Erläuterungen liegt dabei auf einem zweistöckigen Kreuzungsbauwerk, das wie alle anderen Tunnelbauwerke der Ausbaumaßnahme in Bohrpfahl‐Deckelbauweise hergestellt wurde.

The MRO‐Tunnels in Munich.

The construction of the MRO‐Tunnels in Munich represents an important infrastructural measure in the eastern part of the state capital Munich for traffic flow improvement, protection from noise and exhaust pollution as well as for the town development. The main aspects of this paper are the design and the computation of the MRO‐Tunnels with special focus on a complex tunnel crossing, which is located on Einsteinstrasse. The “Top‐Down” construction method was of substantial importance to maintain traffic flow and to extensively reduce impairment to adjacent buildings during the construction period.
Zeitvariantes Trag‐ und Schädigungsverhalten von mehrfach wiederholt beanspruchtem polymermodifizierten Beton (PCC)
Authors: Heidolf Thorsten
Published: November 2009

Auf Basis der in Teil 1 beschriebenen Versuchsergebnisse und der visko‐elastisch‐plastischen Kontinuumsschädigungstheorie werden rheologische Modelle zur Beschreibung des zeit‐ und beanspruchungsabhängigen Tragverhaltens von Beton vorgestellt. Die numerische Umsetzung erfolgt unter Berücksichtigung des zeitabhängigen Betonverhaltens auf der Basis des Hamilton‐Prinzips unter Vernachlässigung der Trägheitskräfte. Die Simulation des beanspruchungsabhängigen Tragverhaltens von Stahlbetonverbundquerschnitten verdeutlicht die Qualität und Leistungsfähigkeit der vorgeschlagenen Modellbildung. Ferner werden ausgewählte praxisrelevante Fragestellungen zum zeit‐ und beanspruchungsabhängigen Betontragverhalten numerisch untersucht.

Time‐Variant Behaviour of Polymer Modified Concrete (PCC) under Repeated Stress with Consideration of Damage Part 2: Modelling the Behaviour of Concrete

Based on experimental results which are described in Part 1 and the theory of visco‐elastic‐plastic continuum damage, rheological models are used to calculate the time‐ and damage‐dependent behaviour of concrete. The numerical concept is based on the Hamilton‐principle. The efficiency of the models was proven by numerical simulation of concrete or reinforced concrete cross sections. In addition, selected practical‐relevant questions about time‐ and load‐dependent behaviour of concrete are numerically investigated.
Torsionsversuche an textilbetonverstärkten Stahlbetonbauteilen
Authors: Schladitz Frank , Curbach Manfred
Published: November 2009

Zur Untersuchung des Torsionstragverhaltens von textilbetonverstärkten Stahlbetonbauteilen wurden Torsionsversuche an Bauteilen mit runden und quadratischen Querschnitten durchgeführt. Anhand von Versuchsergebnissen wird gezeigt, dass durch die Textilbetonverstärkung die Tragfähigkeit und Gebrauchstauglichkeit deutlich verbessert werden kann. Die Ergebnisse der experimentellen Untersuchungen werden mit Hilfe von Stabwerksmodellen beschrieben.

Torsion Test at Textile Reinforced Concrete Strengthened Components

In order to examine the torsion bearing behaviour of textile reinforced concrete components torsion tests have been carried out at building units with round and square shaped cross sections. Test results display that using textile reinforced concrete can considerably improve the load carrying capacity and the serviceability. The results of the experimental research are being described by strut‐and‐tie models.
Emsquerung für die Erdgasleitung A660. Einsatz von stahlfaserbewehrten Tübbingen
Authors: Böhme Thomas , Empelmann Martin , Wichers Marco
Published: November 2009

Im Zuge einer umfassenden Erweiterung des niederländischen Gastransportnetzes wird derzeit westlich von Emden ein ca. 4 km langer Tunnel unter der Ems in Richtung Niederlande errichtet. Der Tunnel dient der Aufnahme einer 48''‐Gasleitung. Nach verschiedenen Variantenstudien wurde als Bauverfahren ein maschineller Tunnelvortrieb mit flüssigkeitsgestützter Ortsbrust und Tübbingausbau gewählt. Die Tübbinge werden aus Stahlfaserbeton ohne konventionelle Stabstahlbewehrung ausgeführt, was aufgrund der projektspezifischen Randbedingungen deutliche Vorteile im Produktionsprozess mit sich bringt. Zur Absicherung dieser Sonderbauweise wurde am iBMB der TU Braunschweig ein Versuchsprogramm zur Ermittlung der Tragfähigkeit und des Gebrauchsverhaltens der Tübbinge während des Tunnelvortriebs und im Endzustand durchgeführt. Der vorliegende Aufsatz stellt das Bauvorhaben vor, nennt wesentliche Randbedingungen zum Einsatz von Stahlfaserbeton und erläutert die experimentellen Untersuchungen.
Grundsätzliche Überlegungen zur Brandprüfung von Tunnelbetonbauteilen
Authors: Dehn Frank , Juknat Michael , Hauswaldt Sebastian
Published: November 2009

Brandprüfungen stellen die derzeit einzige Methode dar, um die brandschutztechnische Wirkung eines Tunnelbauteils zu bestimmen. Der folgende Aufsatz gibt dem Leser einen Überblick über die derzeitige Vorgehensweise bei Tunnelbrandprüfungen.

Zunächst werden übliche Brandkurven, die Brandszenarien in Tunnelbauwerken abbilden, vorgestellt. Darauf aufbauend werden die speziellen Anforderungen an den Prüfstand beschrieben, die zur genauen Ansteuerung der Brandkurven erforderlich sind. Dabei wird unter anderem auf die Schwierigkeit verwiesen, den schnellen Temperaturanstieg innerhalb der ersten Minuten eines Vollbrandszenarios nachzubilden. Es werden Ausführungen zur versuchstechnischen Anordnung der Temperaturmesstechnik in den Betonprobekörpern dargestellt, die zur Bestimmung des Durchwärmungsverhaltens erforderlich sind.

Anschließend werden die relevanten Bewertungskriterien der brandschutztechnischen Wirksamkeit eines Betonbauteils und die Ermittlung der dazu erforderlichen Kenngrößen beschrieben. Als wesentlich sind dabei die Bestimmung der Betonabplatzungen und des Masseverlustes, die Ermittlung des Durchwärmungsverhaltens sowie der Nachweis der Standsicherheit zu nennen. Ergänzend werden Versuchsergebnisse vorgestellt, die den Einfluss von zusätzlichen mechanischen Einwirkungen zur Simulation von realen Schnittgrößen auf den Schädigungsgrad deutlich zeigen.
Untersuchung der Reaktionsprodukte einer Alkali‐Kieselsäure‐Reaktion in einem Versorgungstunnel unter der Ostsee
Authors: Rigo Ellen , Unterderweide Klaus , Schwick Wulf , Diederichs Ulrich
Published: November 2009

Eine bisher wenig publizierte Begleiterscheinung der Alkali‐Kieselsäure‐Reaktion (AKR) ist die Bildung von Trona (Na3[H(CO3)2] · 2H2O) und Thermonatrit (Na2CO3 · H2O) aus einem Alkali‐Kieselsäure‐Gel. Je nach Umgebungsbedingungen (z. B. Temperatur) und Natrium‐Ionenkonzentration kristallisieren diese Verbindungen in und auf dem glasigen AKR‐Gel.

Die Alkali‐Kieselsäure‐Reaktion (AKR) ist eine chemische Reaktion, bei der Alkalien mit reaktionsfähiger, amorpher Kieselsäure im Beton reagieren. Die Alkalien können aus dem verwendeten Zement oder der Gesteinskörnung stammen, sie können aber auch von außen in das Bauwerk eingetragen werden. Letzteres findet man häufig bei der Tausalzbeanspruchung von Fahrbahndecken oder bei Bauwerken, die mit Meerwasser in Berührung kommen. Bei AKR‐Schäden, die durch die äußere Zufuhr von Alkalien entstanden sind, können als Begleitminerale des Alkali‐Kieselsäure‐Gels Natriumhydrogencarbonate in verschiedenen Hydratstufen entstehen. Über diese soll im Weiteren berichtet werden.

Im vorliegenden Schadensfall liegt das Bauwerk, ein Versorgungstunnel, unterhalb der Kieler Förde. Der Tunnel wurde im Jahr 1992 fertig gestellt und zeigt einen so gravierenden AKR‐Schaden, dass Vorbereitungen getroffen wurden, die gesamte Tunnelröhre zu ersetzen. Ursächlich ist in den Beton eintretendes Ostseewasser, welches u. a. mit den alkaliempfindlichen Gesteinskörnungen des Betons eine Alkali‐Kieselsäure‐Reaktion induziert hat. Außerdem entstanden großflächige Ausblühungen von Trona sowie Stalaktiten aus Halit (NaCl) und Sylvin (KCl).
Beton für die Feste‐Fahrbahn im Tunnelabschnitt der Hochgeschwindigkeitsstrecke zwischen Perpignan und Figueras
Authors: Petersen Lasse , Griese Robert , Nietiedt Rainer
Published: November 2009

Im Zuge der Realisierung der neuen LGV‐Hochgeschwindigkeitsverbindung zwischen Paris und Barcelona wurde der Streckenabschnitt von Perpignan bis zur spanischen Grenze erstellt.

Zu diesem Leistungspaket gehörte u. a. der Bau einer Festen Fahrbahn in einer der beiden eingleisigen Tunnelröhren; die Gesamtlänge des Tunnels durch die Pyrenäen, der Frankreich mit Spanien verbindet, beträgt 8.384 m. Im Tunnelbereich wurde das Gleis als Feste Fahrbahn hergestellt. Insgesamt wurden über 8.700 m ausgeführt. Hierzu waren über 6.000 m3 Konstruktionsbeton für die Tragschicht notwendig. Auf Grund der sehr problematischen Tunnelbohrarbeiten standen für die Herstellung der Festen Fahrbahn nur 60 Kalendertage zur Verfügung. Dies erforderte den Einbau in einem Non‐Stop Betrieb. Die Verzögerungen aus den Tunnelbauarbeiten hatten dazu geführt, dass die Betonarbeiten in den Monaten Juli und August auszuführen waren. Neben den terminlichen und logistischen Schwierigkeiten ergaben sich daraus auch schwierige klimatische Bedingungen, speziell für die Betonproduktion und ‐verarbeitung. Auf Grund der Ferienzeit in Frankreich sowie der Problematik des Mehrschichtbetriebes entschied man sich, den Beton mit einer eigenen Mischanlage vor Ort herzustellen.

Für einen ungestörten Bauablauf wurde für den Beton der Fahrbahnplatte eine baustellenrobuste Betonzusammensetzung entwickelt, die die geforderten Frischbeton‐ und Festbetonanforderungen auch unter den zu erwartenden, stark variierenden Herstellbedingungen weitestgehend konstant einhielt. Dabei sind vor allem die Schwankungen in den Umgebungsbedingungen von etwa 20 °C–25 °C nachts und bis zu 45 °C tagsüber zu nennen, die zu einer entsprechenden Beeinflussung der Frischbetontemperaturen führten. In diesem Temperaturbereich mussten vor allem die Frischbetonkonsistenz, die Verarbeitbarkeitszeit sowie die Festigkeitsentwicklung weitestgehend konstant eingestellt werden. Darüber hinaus waren hohe Anforderungen an die Sedimentationsstabilität und geringe Blutneigung des Betons gestellt.

Im vorliegenden Bericht werden zunächst die betontechnischen Anforderungen dargestellt. Anschließend werden die Vorbereitung der Betonherstellung als Baustellenbeton sowie die Entwicklung von geeigneten Betonzusammensetzungen beschrieben. Abschließend werden die Erfahrungen der Bauausführung dargestellt.
Growth plasticity of the embryonic and fetal heart
Authors: Drenckhahn Jörg‐Detlef
Published: November 2009

The developing mammalian heart responds to a variety of conditions, including changes in nutrient availability, blood oxygenation, hemodynamics, or tissue homeostasis, with impressive growth plasticity. This ensures the formation of a functional and normal sized organ by birth. During embryonic and fetal development the heart is exposed to various physiological and potentially pathological changes in the intrauterine environment which dramatically impact on normal cardiac function, tissue composition, and morphology. This paper summarizes the mechanisms employed by the embryonic and fetal heart to adapt to various intrauterine challenges to prevent or minimize postnatal consequences of impaired cardiac development. Future investigations of this growth plasticity might lead to new therapeutic strategies for the prevention of cardiac disease in postnatal life.
Monoallelic gene expression and mammalian evolution
Authors: Keverne Barry
Published: November 2009

Monoallelic gene expression has played a significant role in the evolution of mammals enabling the expansion of a vast repertoire of olfactory receptor types and providing increased sensitivity and diversity. Monoallelic expression of immune receptor genes has also increased diversity for antigen recognition, while the same mechanism that marks a single allele for preferential rearrangement also provides a distinguishing feature for directing hypermutations. Random monoallelic expression of the X chromosome is necessary to balance gene dosage across sexes. In marsupials only the maternal X chromosome is expressed, while in eutherian mammals the paternal X genes are silenced in the developing placenta and early blastocyst. These examples of epigenetic gene regulation commonly employ asynchrony of replication, the binding of polycomb proteins and antisense RNA, and histone modifications to chromatin structure. The same is true for genomic imprinting which among vertebrates is unique to mammals and represents a special kind of epigenetic modification that is heritable according to parent of origin. Genomic imprinting pervades many aspects of mammalian growth and evolution but in particular has played a significant role in the co‐adaptive evolution of the mother and foetus.
Interaction of α‐gliadin with polyanions: Design considerations for sequestrants used in supportive treatment of celiac disease
Authors: Liang Li , Pinier Maud , Leroux Jean‐Christophe , Subirade Muriel
Published: November 2009

Copolymers of sodium 4‐styrene sulfonate (SS) and hydroxyethyl methacrylate (HEMA) were investigated as sequestrants of α‐gliadin, a gluten protein, for the treatment of gluten intolerance. The interactions of α‐gliadin with poly(SS) and poly(HEMA‐co‐SS) with 9 and 26 mol% SS content were studied at gastric (1.2) and intestinal (6.8) pH using circular dichroism and measurements of turbidity, dynamic light scattering and zeta potential. The interactions and their influence on α‐gliadin secondary and aggregated structures depended mainly on the ratio of polymer negative and protein positive charges at pH 1.2, and on polymer SS content at polymer concentrations providing in excess of negative charges at either pH. Poly(SS) could not form complex particles with α‐gliadin in a sufficient excess of negative charges. Copolymerization with HEMA enhanced the formation of complex particles. Poly(HEMA‐co‐SS) with intermediate SS content was found to be the most effective sequestrant for α‐gliadin. This study provides insight into design considerations for polymer sequestrants used in the supportive treatment of celiac disease. © 2009 Wiley Periodicals, Inc. Biopolymers 93:418–428, 2010.

This article was originally published online as an accepted preprint. The “Published Online” date corresponds to the preprint version. You can request a copy of the preprint by emailing the Biopolymers editorial office at biopolymers@wiley.com
Model building in multivariate additive partial least squares splines via the GCV criterion
Authors: Lombardo R. , Durand J. F. , De Veaux R.
Published: November 2009

In the literature, much effort has been put into modeling dependence among variables and their interactions through nonlinear transformations of predictive variables. In this paper, we propose a nonlinear generalization of Partial Least Squares (PLS) using multivariate additive splines. We discuss the advantages and drawbacks of the proposed model, building it via the generalized cross validation criterion (GCV) criterion, and show its performance on a real dataset and on simulated datasets in comparison to other methods based on splines. Copyright © 2009 John Wiley & Sons, Ltd.
Evidence‐based cognitive hypnotherapy for depression
Authors: Alladin Assen
Published: November 2009

Clinical depression is one of the most common psychiatric disorders treated by psychiatrists and psychotherapists. It also poses special problems to therapists as it is a complex disorder that affects the whole person – emotions, bodily functions, behaviours and thoughts. Although depression is treated successfully with antidepressant medication and psychotherapy, a significant number of depressives do not respond to either medication or existing psychotherapies. It is thus important for clinicians to continue to develop more effective treatments for depression. This article describes Cognitive Hypnotherapy (CH), an evidence‐based multimodal treatment for depression, which can be applied to a wide range of patients with depression. The components of CH are described in sufficient detail to allow for their replication and validation. Moreover, CH for depression provides a template for studying the additive effect of hypnosis as an adjunctive treatment with other medical and psychological disorders. Although this article emphasizes evidence‐based practice, this approach should not limit the scope of therapists' creativity in the application of hypnosis to the management of depression. Copyright © 2009 British Society of Experimental & Clinical Hypnosis. Published by John Wiley & Sons, Ltd.
Byproduct‐Catalyzed Four‐Component Reactions of Aldehydes with Hexamethyldisilazane, Chloroformates, and Nucleophiles in Acetonitrile Leading to Protected Primary Amines, β‐Amino Esters, and β‐Amino Ketones
Authors: Yang Bai‐Ling , Weng Zhen‐Tao , Yang Si‐Jie , Tian Shi‐Kai
Published: November 2009

Multicomponent reactions are a very powerful tool for the construction of complex organic molecules by using readily available starting materials. While most of the multicomponent reactions discovered so far consist of three components, the reactions with four or more components remain sparse. We have successfully developed several four‐component reactions using a catalytic amount of water as a hydrolyzing agent to decompose byproduct chlorotrimethylsilane (TMSCl) to yield secondary byproduct HCl that serves as a catalyst. In the presence of 40 mol % of water, the four‐component reaction of aldehydes with hexamethyldisilazane (HMDS), chloroformates, and silylated nucleophiles proceeds smoothly at room temperature to give a range of protected primary amines in moderate to excellent yields. Importantly, a wide variety of protic carbon nucleophiles, such as β‐keto esters, β‐diketones, and ketones, have further been explored as suitable substrates for the synthesis of protected β‐amino esters and β‐amino ketones that are useful building blocks for various pharmaceuticals and natural products. These four‐component reactions proceed through a pathway of tandem nitrogen protection/imine formation/imine addition, and the decomposition of byproduct TMSCl, generated in the first step of nitrogen protection, with water results in the formation of secondary byproduct HCl, a strong Brønsted acid that catalyzes the following imine formation/imine addition. Taking advantage of the fact that alcohols or phenols are also able to decompose byproduct TMSCl to yield secondary byproduct HCl, no catalyst is needed at all for the four‐component reactions with aldehydes bearing hydroxy groups.
ChemInform Abstract: On the Crystal Structures of Ln3MO7 (Ln: Nd, Sm, Y and M: Sb, Ta) — Rietveld Refinement Using X‐Ray Powder Diffraction Data.
Authors: Fu W. T. , Ijdo D. J. W.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Structure, Crystal Chemistry and Thermal Evolution of the δ‐Bi2O3‐Related Phase Bi9ReO17.
Authors: Sharma Neeraj , Withers Ray L. , Knight Kevin S. , Ling Chris D.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Improved Thermoelectric Properties of Cu‐Doped Quaternary Chalcogenides of Cu2CdSnSe4.
Authors: Liu Min‐Ling , Chen I‐Wei , Huang Fu‐Qiang , Chen Li‐Dong
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Detailed Phase Analysis and Crystal Structure Investigation of a Bi1‐xCaxFeO3‐x/2 Perovskite‐Related Solid Solution Phase and Selected Property Measurements Thereof.
Authors: Schiemer Jason , Withers Ray , Noren Lasse , Liu Yun , Bourgeois Laure , Stewart Glen
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Pd—C—Fe Nanoparticles Investigated by X‐Ray Absorption Spectroscopy as Electrocatalysts for Oxygen Reduction.
Authors: Yeh Yun‐Chieh , Chen Hao Miing , Liu Ru‐Shi , Asakura Kiyotaka , Lo Man‐Yin , Peng Yu‐Min , Chan Ting‐Shan , Lee Jyh‐Fu
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: High‐Pressure Syntheses and Crystal Structures of Monoclinic B‐Ho2O3 and Orthorhombic HoGaO3.
Authors: Hering Stefanie A. , Huppertz Hubert
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Crystal Structure of NZP‐Type Thorium—Zirconium Phosphate.
Authors: Orlova Albina I. , Volgutov Valeriy Yu. , Castro German R. , Garcia‐Granda Santiago , Khainakov Sergei A. , Garcia Jose R.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: RbAuUSe3, CsAuUSe3, RbAuUTe3, and CsAuUTe3: Synthesis and Structure; Magnetic Properties of RbAuUSe3.
Authors: Bugaris Daniel E. , Ibers James A.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: PbMn(SO4)2: A New Chiral Antiferromagnet.
Authors: West D. V. , Posen I. D. , Huang Q. , Zandbergen H. W. , McQueen T. M. , Cava R. J.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: The Ternary Nitrides GaFe3N and AlFe3N: Improved Synthesis and Magnetic Properties.
Authors: Houben Andreas , Burghaus Jens , Dronskowski Richard
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Donor‐Stabilized Phosphenium Adducts as New Efficient and Immobilizing Ligands in Palladium‐Catalyzed Alkynylation and Platinum‐Catalyzed Hydrogenation in Ionic Liquids.
Authors: Saleh Samer , Fayad Elie , Azouri Michele , Hierso Jean‐Cyrille , Andrieu Jacques , Picquet Michel
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Enantioselective Sulfenylation of β‐Ketoesters: H‐Bond Acceptor Catalysis.
Authors: Fang Ling , Lin Aijun , Hu Hongwen , Zhu Chengjian
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Novel Chiral C2‐Symmetric Bisimidazole‐N‐oxides as Promising Organocatalysts for Enantioselective Allylation of Aromatic Aldehydes.
Authors: Kwiatkowski Piotr , Mucha Paulina , Mloston Grzegorz , Jurczak Janusz
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: N‐Primary‐Amine‐Terminal β‐Turn Tetrapeptides as Organocatalysts for Highly Enantioselective Aldol Reaction.
Authors: Wu Feng‐Chun , Da Chao‐Shan , Du Zhi‐Xue , Guo Qi‐Peng , Li Wei‐Ping , Yi Lei , Jia Ya‐Ning , Ma Xiao
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Ni‐Catalyzed Carbocyclization of 1,6‐Enynes Mediated by Dialkylzinc Reagents: Me2Zn or Et2Zn Makes a Difference.
Authors: Chai Zhuo , Wang Hai‐Feng , Zhao Gang
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Dicyanomethylene Compounds and Heterocyclization of Substituted Carbohydrazides.
Authors: Hassan Alaa A. , Ibrahim Yusria R. , Shawky Ahmed M.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Synthesis and Biological Screening of Some Fluorinated Dibenzofuran Containing 3‐Chlorochromones and Benzothiazepines.
Authors: Randhavane Pratibha , Karale Bhausaheb
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Aldehyde Selective Wacker Oxidations of Phthalimide Protected Allylic Amines: A New Catalytic Route to β3‐Amino Acids.
Authors: Weiner Barbara , Baeza Alejandro , Jerphagnon Thomas , Feringa Ben L.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Highly Efficient Asymmetric Epoxidation of Electron‐Deficient α,β‐Enones and Related Applications to Organic Synthesis.
Authors: Zheng Changwu , Li Yawen , Yang Yingquan , Wang Haifeng , Cui Haifeng , Zhang Junkang , Zhao Gang
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Electrochemical Method for the Preparation of Dibromomethyl, Bis(bromomethyl), and Bis(dibromomethyl) Arenes.
Authors: Kulangiappar K. , Karthik G. , Kulandainathan M. Anbu
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric α‐Amination of Aldehydes and Ketones Catalyzed by tert‐Butoxy‐L‐Proline.
Authors: Ait‐Youcef Ramzi , Kalch Delphine , Moreau Xavier , Thomassigny Christine , Greck Christine
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Trifunctional N,N,O‐Terdentate Amido/Pyridyl Carboxylate Ligated Pd(II) Complexes for Heck and Suzuki Reactions.
Authors: Kantam M. Lakshmi , Srinivas P. , Yadav Jagjit , Likhar Pravin R. , Bhargawa Suresh
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Microwave‐Assisted Ester Formation Using O‐Alkylisoureas: A Convenient Method for the Synthesis of Esters with Inversion of Configuration.
Authors: Chighine Alessandra , Crosignani Stefano , Arnal Marie‐Claire , Bradley Mark , Linclau Bruno
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Preparation of Mono Boc‐Protected Unsymmetrical Diamines.
Authors: Li Hongbo , Hao Meng‐an , Wang Liping , Liang Wu , Chen Kai
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Asymmetric 1,4‐Dihydroxylation of 1,3‐Dienes by Catalytic Enantioselective Diboration.
Authors: Burks Heather E. , Kliman Laura T. , Morken James P.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: A Convenient Triisobutylaluminum (TlBAL)‐Promoted Johnson—Claisen Approach to γ,δ‐Unsaturated Alcohols.
Authors: Cosgrove Kelly L. , McGeary Ross P.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Stereoselective SN2′ Alkylation Reaction Sequence of the γ,δ‐Epoxy α,β‐Unsaturated Ester System via γ,δ‐Chlorohydrin Intermediates by the Use of a R3Al—CuCN Reagent.
Authors: Yoshimura Fumihiko , Matsui Atsushi , Hirai Atsushi , Tanino Keiji , Miyashita Masaaki
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Phosphine‐Mediated Olefination Between Aldehydes and Allenes: An Efficient Synthesis of Trisubstituted 1,3‐Dienes with High E‐Selectivity.
Authors: Xu Silong , Zhou Lili , Zeng San , Ma Renqin , Wang Zhihong , He Zhengjie
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Enantioselective Conjugate Addition of Fluorobis(phenylsulfonyl)methane to α,β‐Unsaturated Ketones Catalyzed by Chiral Bifunctional Organocatalysts.
Authors: Moon Hyoung Wook , Cho Min Je , Kim Dae Young
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Formal Highly Enantioselective Organocatalytic Addition of Fluoromethyl Anion to α,β‐Unsaturated Aldehydes.
Authors: Alba Andrea‐Nekane , Companyo Xavier , Moyano Albert , Rios Ramon
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Addition Reactions of Sulfonylimidates with Imines Catalyzed by Alkaline Earth Metals.
Authors: Nguyen Huy Van , Matsubara Ryosuke , Kobayashi Shu
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Simple and Facile Method for the Preparation of Vinyl Azides.
Authors: Telvekar Vikas N. , Takale Balaram S. , Bachhav Harshal M.
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.
ChemInform Abstract: Iridium‐Catalyzed Coupling Reaction of Primary Alcohols with 1‐Aryl‐1‐propynes Leading to Secondary Homoallylic Alcohols.
Authors: Obora Yasushi , Hatanaka Shintaro , Ishii Yasutaka
Published: November 2009

ChemInform is a weekly Abstracting Service, delivering concise information at a glance that was extracted from about 200 leading journals. To access a ChemInform Abstract of an article which was published elsewhere, please select a “Full Text” option. The original article is trackable via the “References” option.