bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of positive airway pressure compliance on laryngopharyngeal reflux in obstructive sleep apnea patients
Authors: Tawaranurak Krongthong , Werathammo Methini
Published: June 2023

Objectives

To determine the effect of continuous positive airway pressure (CPAP) compliance on symptoms and signs of laryngopharyngeal reflux (LPR) in patients with obstructive sleep apnea (OSA).

Results

Thirty patients were included. The participants were divided into good compliance (n = 21) and poor compliance (n = 9) groups. After 6-month CPAP treatment, the reflux symptom index score significantly decreased in both the good compliance group (20 (17,24) vs. 14 (10,18), p < 0.001) and the poor compliance group (21 (18,25) vs. 10 (5,16), p < 0.05). Reflux finding score was significantly reduced in both the good compliance group (8 (6,9) vs. 4 (3,5), p < 0.001) and the poor compliance group (6 (4,8) vs. 3 (2,4), p < 0.05). However, there were no statistically significant differences between the groups. CPAP treatment reduces the symptoms and signs of LPR. However, CPAP compliance does not correlate with improvement in LPR in patients with OSA.
A multicomponent complex intervention for supportive follow-up of persons with chronic heart failure: a randomized controlled pilot study (the UTILE project)
Authors: Schäfer-Keller Petra , Graf Denis , Denhaerynck Kris , Santos Gabrielle Cécile , Girard Josepha , Verga Marie-Elise , Tschann Kelly , Menoud Grégoire , Kaufmann Anne-Laure , Leventhal Marcia , Richards David A. , Strömberg Anna
Published: June 2023

Background

Heart failure (HF) is a progressive disease associated with a high burden of symptoms, high morbidity and mortality, and low quality of life (QoL). This study aimed to evaluate the feasibility and potential outcomes of a novel multicomponent complex intervention, to inform a future full-scale randomized controlled trial (RCT) in Switzerland.

Methods

We conducted a pilot RCT at a secondary care hospital for people with HF hospitalized due to decompensated HF or with a history of HF decompensation over the past 6 months. We randomized 1:1; usual care for the control (CG) and intervention group (IG) who received the intervention as well as usual care. Feasibility measures included patient recruitment rate, study nurse time, study attrition, the number and duration of consultations, intervention acceptability and intervention fidelity. Patient-reported outcomes included HF-specific self-care and HF-related health status (KCCQ-12) at 3 months follow-up. Clinical outcomes were all-cause mortality, hospitalization and days spent in hospital.

Results

We recruited 60 persons with HF (age mean = 75.7 years, ± 8.9) over a 62-week period, requiring 1011 h of study nurse time. Recruitment rate was 46.15%; study attrition rate was 31.7%. Follow-up included 2.14 (mean, ± 0.97) visits per patient lasting a total of 166.96 min (mean, ± 72.55), and 3.1 (mean, ± 1.7) additional telephone contacts. Intervention acceptability was high. Mean intervention fidelity was 0.71. We found a 20-point difference in mean self-care management change from baseline to 3 months in favour of the IG (Cohens’ d = 0.59). Small effect sizes for KCCQ-12 variables; less IG participants worsened in health status compared to CG participants. Five deaths occurred (IG = 3, CG = 2). There were 13 (IG) and 18 (CG) all-cause hospital admissions; participants spent 8.90 (median, IQR = 9.70, IG) and 15.38 (median, IQR = 18.41, CG) days in hospital. A subsequent full-scale effectiveness trial would require 304 (for a mono-centric trial) and 751 participants (for a ten-centre trial) for HF-related QoL (effect size = 0.3; power = 0.80, alpha = 0.05).

Conclusion

We found the intervention, research methods and outcomes were feasible and acceptable. We propose increasing intervention fidelity strategies for a full-scale trial.

Trial registration

ISRCTN10151805, retrospectively registered 04/10/2019.
Regenerative capacity of trophoblast stem cell-derived extracellular vesicles on mesenchymal stem cells
Authors: Go Yoon-Young , Lee Chan-mi , Chae Sung-Won , Song Jae-Jun
Published: June 2023

Background

Human mesenchymal stem cells (MSCs) are therapeutic for clinical applications because of their excellent immunomodulatory and multiple lineage differentiation abilities at tissue injury sites. However, insufficient number of cells and lack of regenerative properties during in vitro expansion still limit the clinical applicability of MSC therapies. Here, we demonstrated a preconditioning strategy with trophoblast stem cell-derived extracellular vesicles (TSC-EVs) to boost the proliferation and regenerative capacity of MSCs.

Methods

We employed cell proliferation analyses such as CCK8 and BrdU assays to determine the proliferation-promoting role of TSC-EVs on MSCs. Osteogenic effects of TSC-EVs on MSCs were assessed by alkaline phosphatase (ALP) activity, calcium assays, and calvarial bone defect animal models. For skin regenerative effects, skin wound mice model was exploited to analyze wound-healing rate in this study, as well as immunofluorescence and histological staining evaluates. We also performed the small RNA profiling and RNA-sequencing analyzes to understand the cellular mechanism of TSC-EVs on MSCs.

Results

TSC-EVs significantly promoted MSC proliferation under xeno-free conditions and facilitated the therapeutic effects of MSCs, including osteogenesis, anti-senescence, and wound healing. Transcriptomic analysis also provided evidence that specific microRNAs in TSC-EVs and differentially expressed genes (DEGs) in TSC-EV-treated MSCs showed the possibility of TSC-EVs triggering the regenerative abilities of MSCs with cytokine interaction. Hence, we found that NGF/Akt signaling mediated the regenerative effects of TSC-EVs on MSCs as a particular cellular signaling pathway.

Conclusion

The results of this study demonstrated the functional properties of TSC-EVs on MSCs for MSC-based therapeutic applications, suggesting that TSC-EVs may serve as a potential preconditioning source for MSC therapy in the clinical field of regenerative medicine.

Graphical abstract
Immunotherapy-induced thyroid dysfunction: an updated review
Authors: Baraka Bahaaeldin , Abosheaishaa Hazem , Nassar Mahmoud
Published: June 2023

Immunotherapy medicines (immune checkpoint inhibitors, ICIs) that work directly on the immune system have shown vastly increased survival for people with cancer in phases 2 and 3 clinical studies during the past few years. Nevertheless, ICI treatment (irAEs) may trigger immune-related adverse effects. An underactive thyroid is among the most frequent endocrine irAE, affecting about 40% of individuals who received ICIs. Our review aims to collect and organize the most recent data on immunotherapy-induced thyroid dysfunction in cancer patients, including its prevalence, diagnostic criteria, and treatment options and to summarize those findings in a comprehensive review article. The incidence of irAEs varies depending on the type of cancer and the treatment regimen. Thyroid ultrasound, radioactive uptake scan, and PET CT scan can aid in diagnosing thyroid dysfunction. Thyroid dysfunction treatment necessitates collaboration between specialists in oncology, endocrinology, and primary care in a multidisciplinary team discussion. The prognosis of patients who suffered from thyroid dysfunction while on ICIs treatment is reasonably good. Suboptimal baseline thyroid function was linked with decreased overall survival (OS) among ICI-treated patients, but initiating replacement hormonal therapy after ICI initiation was associated with enhanced OS. More research work is required to identify these links and mechanisms of action.
A greedy algorithm for pilot contamination mitigation using LAP
Authors: Ngala Daniel Kuyoli , Opare Kwasi Adu-Boahen , Affum Emmanuel Ampoma , Oteng Gyasi Kwame , Agyekum Kwame Opuni-Boachie Obour
Published: June 2023

In this paper, we propose a linear assignment problem (LAP) scheme using greedy algorithms to alleviate the intercell interference (ICI) in massive multi-input multiple-output (maMIMO) systems. ICI has been recognized as one of the main challenges of massive MIMO systems and occurs when pilot sequences (PSs) are reused across neighboring cells or using non-orthogonal PS, and this results in a phenomenon known as pilot contamination (PC). The proposed scheme uniquely assigns pilot sequences to mobile terminals to mitigate PC such that the optimal or near-optimal solution is achieved. This scheme attains maximum SINR by assigning pilot sequence to mobile terminals that will only produce the least PC. Results obtained from simulation showed that the proposed assignment scheme achieved a greater sum rate than some established assignment schemes when compared.
Preparation of inorganic catalysts from ceramic industry wastes for use in the production of biofuel
Authors: Hassan Sarah Hisham , Attia Nahed Kamal , El Diwani Guzine Ibrahim , Ettouney Reem Sayed , El-Rifai Mahmoud Abdel Hakim , Amin Shereen Kamel
Published: June 2023

Catalysts’ surface structural features and characterizations play an important role in many chemical industrial processes among which is biofuel production. Heterogeneous catalysts strongly affect the types of products in catalytic hydrocracking of oils. The present study aims at the preparation of low-cost inorganic catalysts with improved catalytic activity. This will then be used in the production of bio-jet fuel — conforming to ASTM specifications — by hydrocracking of Jatropha oil. Five types of inorganic catalysts have been prepared and tested. The best results were obtained from the catalyst produced from ceramic wastes. It produced the highest bio-jet yield (51%) and the highest freezing point (− 52 °C). A BET surface area of 21.9 m2/g and a "total pore volume" of 0.025877 cm3/g were obtained.
Interventions to prevent alcohol use: systematic review of economic evaluations
Authors: Le Long Khanh-Dao , Faller Jan , Chatterton Mary Lou , Perez Joahna Kevin , Chiotelis Oxana , Tran Huong Ngoc Quynh , Sultana Marufa , Hall Natasha , Lee Yong Yi , Chapman Cath , Newton Nicola , Slade Tim , Sunderland Matt , Teesson Maree , Mihalopoulos Cathrine
Published: June 2023

Background

Alcohol use is a leading risk factor for death and disability worldwide.

Aims

We conducted a systematic review on the cost-effectiveness evidence for interventions to prevent alcohol use across the lifespan.

Method

Electronic databases (EMBASE, Medline, PsycINFO, CINAHL and EconLit) were searched for full economic evaluations and return-on-investment studies of alcohol prevention interventions published up to May 2021. The methods and results of included studies were evaluated with narrative synthesis, and study quality was assessed by the Drummond ten-point checklist.

Results

A total of 69 studies met the inclusion criteria for a full economic evaluation or return-on-investment study. Most studies targeted adults or a combination of age groups, seven studies comprised children/adolescents and one involved older adults. Half of the studies found that alcohol prevention interventions are cost-saving (i.e. more effective and less costly than the comparator). This was especially true for universal prevention interventions designed to restrict exposure to alcohol through taxation or advertising bans; and selective/indicated prevention interventions, which involve screening with or without brief intervention for at-risk adults. School-based interventions combined with parent/carer interventions were cost-effective in preventing alcohol use among those aged under 18 years. No interventions were cost-effective for preventing alcohol use in older adults.

Conclusions

Alcohol prevention interventions show promising evidence of cost-effectiveness. Further economic analyses are needed to facilitate policy-making in low- and middle-income countries, and among child, adolescent and older adult populations.
The disproportionality of ethnic minority teachers in England: trends, patterns, and problems
Authors: Gorard Stephen , Chen Wenqing , Tan Yiyi , See Beng Huat , Gazmuri Carolina , Tereshchenko Antonina , Demie Feyisa , Siddiqui Nadia
Published: June 2023

Abstract

Background: England has an ethnically diverse population; reflected in the teacher workforce, and the student body in schools. However, it is not clear that these figures are in proportion to each other. This paper examines the ethnic profile of students and their teachers and considers their geographical distribution.

Methods: This paper uses existing aggregated official publicly available datasets to describe the patterns and trends in the proportion of ethnic minority teachers compared to ethnic minority pupils in England 2015-2021. Data comes from the Department for Education (DfE), the University and Colleges Admissions Service (UCAS), the Organisation for Economic Co-operation and development (OECD/TALIS), and the Office for National Statistics (ONS).

Results:  We found that there are proportionately more White British teachers than in the student intakes to schools. This disproportion (where there are more White British teachers among teachers than there are White British pupils among pupils) is worse for promoted school leaders like deputies and headteachers than it is for classroom teachers. In London, due to the exceptional number of ethnic minority students, the disproportion (or mismatch) is worse in London than anywhere else. Areas with the fewest ethnic minority pupils (and teachers), like the North East, have the most proportionate workforce (in this limited sense).

Conclusions: A student lacking any teachers of the same ethnic group might be treated differently at school, and there is some evidence that this might affect their attainment outcomes. The lack of ethnic diversity in some schools and areas, regardless of proportions, may impoverish the diversity of the whole school system. Several possible reasons for these patterns are noted in the paper, but it is clear that ethnic minority applicants to teacher training are less likely to be accepted, and less likely to obtain qualified teacher status or an eventual teaching post.
The genome sequence of the Squinting Bush Brown, Bicyclus anynana (Butler, 1879)
Authors: Saccheri Ilik J. ,   Wellcome Sanger Institute Tree of Life programme,   Wellcome Sanger Institute Scientific Operations: DNA Pipelines collective,   Tree of Life Core Informatics collective,   Darwin Tree of Life Consortium
Published: June 2023

We present a genome assembly from an individual female Bicyclus anynana (the Squinting Bush Brown; Arthropoda; Insecta; Lepidoptera; Nymphalidae). The genome sequence is 457.2 megabases in span. Most of the assembly is scaffolded into 28 chromosomal pseudomolecules, including the Z sex chromosome. The mitochondrial genome has also been assembled and is 16.1 kilobases in length.
Basics of city management
Authors: Grebennikova Anna , Osipova Irina , Saltykova Ol'ga , Mokeev Maksim , Naumov Sergey , Vedyaeva Ekaterina
Published: June 2023

The textbook contains the main questions on the disciplines of the municipal block and is designed to form the level of training of students determined by both the state standard and additional requirements established by educational institutions.
Prepared in accordance with the federal state educational standard for the course "Fundamentals of city Management" for students of higher educational institutions in the specialty 38.03.04 "State and municipal Management".
Working with the textbook will assist students in preparing for exams, and can also be useful in practical activities for teachers, municipal employees, deputies of representative bodies of local authorities and anyone interested in the development of urban governance in Russia.
Logic with elements of mathematical logic
Authors: IGOShIN Vladimir
Published: June 2023

In the textbook, traditional logic is presented from the point of view of mathematical logic. Mathematization begins with the study of the topic "Concept", continues with the topic "Judgment" and reaches its greatest effectiveness in the study of deductive reasoning. Thus, the most effective part of traditional logic is subjected to mathematization.
The issues of the relationship between logic and intuition in thought processes, the role of language in them, as well as plausible conclusions and elements of the theory of fuzzy sets and fuzzy logic are considered.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
It is addressed primarily to students of mathematical fields of study and specialties of universities, especially future teachers of mathematics and computer science, studying both at the bachelor's and master's level at pedagogical and classical universities. It will also be useful for students of humanities and university specialties — lawyers, philosophers, political scientists, sociologists, economists, historians, philologists, linguists who study traditional logic and want to learn how mathematical methods penetrate into humanitarian fields of knowledge, including the direction of "Applied Informatics".
Forensic accounting expertise
Authors: Timchenko Vladimir
Published: June 2023

The textbook contains information on the main topics of the discipline "Forensic accounting expertise". The textbook discusses the theoretical and practical aspects of the production of forensic accounting expertise as an independent kind, included in the class of forensic economic expertise. Both general methods and techniques of forensic accounting expertise and the methodology of this examination on the most important issues are presented.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of higher educational institutions studying in the specialty 40.05.03 "Forensic examination" according to specialty programs, as well as teachers, practitioners, experts, persons initiating the appointment of forensic accounting expertise - judges, investigators, defenders and other participants in the process.
General surgery. Educational games
Authors: Oskretkov Vladimir , Ceymah Evgeniy , Maslikova Svetlana
Published: June 2023

The textbook is presented in the form of educational games simulating various clinical situations that need to be resolved by a medical university student studying the subject of "General Surgery". Commenting on all the student's actions, both right and wrong, allows a deeper understanding of their consequences for the patient. The result of each chapter is a statement of the principles that must be followed when using theoretical knowledge in medical practice. It is intended for active self-preparation of students for practical classes using the knowledge provided by the federal state educational standards of higher education of the latest generation in general surgery, normal anatomy, normal and pathological physiology, propaedeutics of internal diseases.
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of medical, pediatric, preventive medicine and dental faculties.
Personnel security
Authors: Karzaeva Natal'ya , Karanina Elena
Published: June 2023

The textbook contains theoretical material on the discipline "Personnel security of the organization", control questions for preparation for lectures and practical classes and intermediate certification (exam or test).
Meets the requirements of the federal state educational standards of higher education of the latest generation.
For students of higher educational institutions studying in the field of "Economic security", as well as university teachers and specialists working in the field of personnel security of organizations of various forms of ownership.
Wind turbines with optimal control of electricity generation
Authors: Buyal'skiy Vladimir
Published: June 2023

In the monograph, based on the analysis of modern methods of automatic control of wind power installations, a solution is proposed for the correct connection (in theoretical terms) of related problems of dynamic behavior of power units with optimal control of electricity generation. In this direction, principles, structures and algorithms have been obtained to reduce the dynamic loads of the components of modern wind turbines based on timely preparation of the system for external disturbing influences and taking into account the vibration load of the drive under different operating modes of the power unit.
It is intended for researchers and specialists in the field of wind energy, automation of technological processes, system analysis, as well as graduate students and students of relevant training areas and specialties of technical universities.
Liposomal forms of nootropic drugs
Authors: Polkovnikova Yuliya
Published: June 2023

The monograph summarizes the results of our own research in comparison with the literature data on the development of the composition and technology of liposomal dosage forms of nootropic action.
It is intended for researchers in the field of pharmacy, biology and medicine, as well as for pharmacists, teachers, graduate students, residents and students engaged in scientific research.
Friction fiber-reinforced ceramic-matrix composite materials
Authors: Garshin Anatoliy , Nilov Aleksey , Kulik Viktor
Published: June 2023

The monograph summarizes the results of the analysis of the main features of fiber-reinforced composite materials with a ceramic matrix and fiber fillers used for their reinforcement. The main technological methods of obtaining ceramic-matrix composites based on solid, gas and liquid-phase processes are considered. The results of the assessment of the current state and prospects for the development of friction elements in braking systems of high-energy transport equipment are presented. The main directions of increasing the corrosion, heat and wear resistance of composite materials with a ceramic matrix are considered, as well as evaluation of the physico-mechanical and thermophysical characteristics of composite materials with a ceramic matrix designed to work under conditions of high mechanical and temperature loads and abrasive wear. Recommendations on the selection of friction pairs for brake discs made of composite materials with a ceramic matrix are given.
For students, postgraduates and teachers of technical universities and faculties.
Descriptive geometry: a practical course
Authors: Sal'kov Nikolay , Sal'kov Nikolay
Published: June 2023

The textbook is designed to help first-year students in the first semester to complete coursework on descriptive geometry, consisting of a number of traditional tasks. It is considered together with the textbooks "Collection of problems on descriptive geometry" and "Descriptive geometry: assignments for term papers".
For students of higher educational institutions studying in the areas of "Architecture", "Design". It is of interest to all students of descriptive geometry.
Occupation of the highest position in the criminal hierarchy (Article 210.1 of the Criminal Code of the Russian Federation): qualification and investigation
Authors: Bagmet Anatoliy , Bychkov Vasiliy , Harchenko Sergey , Shuruhnov Vladimir
Published: June 2023

The monograph reveals the concepts of organized crime and the occupation of the highest position in the criminal hierarchy, examines the evolution of domestic organized crime, characterizes the criminal legal characteristics of the occupation of the highest position in the criminal hierarchy, provided for in Article 210.1 of the Criminal Code of the Russian Federation. The features of the identification, disclosure and investigation of the occupation of the highest position in the criminal hierarchy are considered. The features of countering the investigation of the occupation of the highest position in the criminal hierarchy and measures to neutralize it are revealed.
It is intended for law enforcement officers specializing in the detection, disclosure and investigation of organized criminal activity, as well as for students of law enforcement institutions of higher education.
Global Cities and Multinational Enterprises: Integrating the Existing Concepts for Future Research Studies
Authors: Kola-Bezka Maria , Kuzel Marcin
Published: June 2023

Global Cities (GCs) and Multinational Enterprises (MNEs) belong to a group of entities that shape the modern world economy in the most distinct way. So far, both of them have been given a lot of attention in the literature, but few studies have been written linking these two important threads of deliberation remaining the aspects of relationships between GCs and MNEs relatively unexplored. This is surprising as GCs and MNEs are not sole players but symbionts in the world economy. Hence, the intention of the authors – and the aim of this paper – is to overview these issues and connect GC and MNE threads in order to provide a platform for future research studies. By adopting an evolutionary approach and integrating the perspectives of economic geography, urban studies and international business, the paper identifies several research areas that may be fundamental to the GC/MNE discussion. They have been grouped in the following five thematic categories: global trends, international and country-specific factors; heterogeneity and transformation of global cities; MNE internationalization motivations and different market entry modes; global cities and global value chains; outcomes of MNE activity.
Blue light emitted from digital devices - impact on our sleep
Authors: Kurek Justyna , Gadomska Anna , Gorzyński Rafał , Molczyk-Sieńczak Justyna , Garstka Michał , Dominik Hanna , Czudy Zuzanna , Pawęska Wojciech , Radwański Jan , Polatowska Marika
Published: June 2023

Introduction: Today the use of digital devices is widespread in society. It has been observed increased frequency of sleep disorders occurring in the population in every age group. Scientists, concerned about the scale of the problem, have become interested in the effects of blue light emitted by the displays of digital devices, on sleep.
Purpose of the work: The aim of the study is to answer the question whether a blue light emitted by digital devices affects sleep and to indicate the potential prevention of sleep disorders resulting from the use of digital devices.
Materials and methods: A literature review was performed in the PubMed database using the keywords: blue light exposition; sleep quality; insomnia; light emitting diode; electronic device.
Summary: Blue light emitted by various digital devices affects sleep by shortening and deteriorating the quality of sleep, falling asleep later, exacerbating feelings of sleep deprivation and increasing feelings of fatigue. Scientists have identified a couple of possible mechanisms to explain this phenomenon. There is a method that allows to reduce the negative effects of using various electronic equipment, without having to limit the length or set a rigid time frame for their use. Due to the increasing problem of sleep disorders and new habits among the society, scientists point out the need to monitor the discovered impact of blue light on sleep.
A family of distal functions and multipliers for strict ergodicity
Authors: Glasner Eli
Published: June 2023

We give two proofs to an old result of E. Salehi,
showing that the Weyl subalgebra $\mathcal{W}$ of $\ell^\infty(\Z)$ is a proper subalgebra of $\mathcal{D}$,
the algebra of distal functions.
We also show that the family
$\mathcal{S}^d$ of strictly ergodic functions in $\mathcal{D}$ does not form an algebra and hence in
particular does not coincide with $\mathcal{W}$.
We then use similar constructions to show that
a function which is a multiplier for strict ergodicity,
either within $\mathcal{D}$ or in general, is necessarily a constant.
An example of a metric, strictly ergodic, distal flow
is constructed which admits a non-strictly ergodic $2$-fold minimal self-joining.
It then follows that the enveloping group of this flow is not strictly ergodic (as a $T$-flow).
Finally we show that the distal, strictly ergodic Heisenberg nil-flow is relatively
disjoint over its largest equicontinuous factor from the universal Weyl flow $|\mathcal{W}|$.
Existence of nontrivial solutions to Schrödinger systems with linear and nonlinear couplings via Morse theory
Authors: Zhang Zhitao , Yu Meng , Zheng Xiaotian
Published: June 2023

In this paper, we use Morse theory to study existence of nontrivial solutions to the following Schrödinger system with linear and nonlinear couplings which arises from Bose-Einstein condensates:
$$
\begin{cases}
-\Delta u+\lambda_{1} u+\kappa v=\mu_{1} u^{3}+\beta uv^{2}
& \text{in } \Omega,\\
-\Delta v+\lambda_{2} v+\kappa u=\mu_{2} v^{3}+\beta vu^{2}
& \text{in } \Omega,\\
u=v=0 & \text{on } \partial\Omega,
\end{cases}
$$
where $\Omega$ is a bounded smooth domain in $\mathbb{R}^{N}$($N=2,3$),
$\lambda_{1},\lambda_{2},\mu_{1},\mu_{2} \in \mathbb{R} \setminus \{ 0 \}$,
$\beta, \kappa \in \mathbb{R}$.
In two cases of
$\kappa=0$ and $\kappa\neq 0$, by transferring an eigenvalue problem into an algebraic problem, we compute the Morse index and critical groups of the trivial
solution. Furthermore, even when the trivial solution is degenerate,
we show a local linking structure of energy functional at zero within a suitable
parameter range and then get critical groups of the trivial solution.
As an application, we use Morse theory to get an existence theorem on existence
of nontrivial solutions under some conditions.
Local Morrey estimate in Musielak-Orlicz-Sobolev space
Authors: Liu Duchao , Zhao Peihao
Published: June 2023

Under appropriate assumptions on the $N(\Omega)$-fucntion, locally uniform Morrey
estimate is presented in the Musielak-Orlicz-Sobolev space. The assumptions
include a new increasing condition on the $x$-derivative of the Young complementary function of the $N(\Omega)$-fucntion. The conclusion applies
to several important nonlinear examples frequently appeared in mathematical literature.
Teofila z Jabłonowskich Sapieżyna (1742-1816): Życie prywatne i działalność publiczna
Authors: Blinda Angelika
Published: June 2023

The publication is devoted to the biography of one of the most prominent female members of the Bar Confederation, Teofila Sapieżyna, née Jabłonowska, the wife of the grand krajczy of Lithuania, whose activity has not been the subject of an indepth analysis by historians. The monograph is structured thematically and chronologically, and consists of seven chapters. Chapter One focuses on Teofila Sapieżyna’s life before the establishment of the Bar Confederation in 1768 – her ancestry, family ties, education and the early years of her marriage to Józef Sapieha. The next part of the publication presents the activity of the duchess in the Bar Confederation. In addition to listing her activities, the chapter presents her motivation, the people with whom she was in the closest contact at that time and the way in which she built her position among confederates. The third chapter is devoted to the duchess’s remarks on the current situation in Europe, the status of the Bar Confederation on the international stage, the directions of searching possible allies and her attitude to the activities of the confederates at European courts. The further chapters focus on Teofila Sapieżyna’s stay in France. The fourth one, presents her attitude towards the preparations to the Partition Sejm and its proceedings, as well as towards the King Stanisław August and the international situation after the fall of the Bar Confederation. The main focus is put on the analysis of her relationship with the French court, particularly Maria Anna Ludwika Jabłonowska, princesse de Talmont, Françoise de Chalus, comte de Narbonne, and the daughter of King Luis XV Marie Adélaïde. This is of particular importance due to the fact that Teofila Sapieżyna’s standing with the royalty greatly strengthened her position among the confederates, earning her a reputation as a very influential person. On the other hand, she attempted to leverage her connections to draw the attention of the French elite to the situation that the Bar Confederation was in, and also to help her husband to obtain a military rank in the French army. The fifth chapter presents the social circle of the Sapieha family and their private life, including their increasing financial difficulties and the reasons why they decided to return to their homeland in 1777.
Literature Review: Pengaruh Brand Image Terhadap Produk Kuliner Rendang di Sumatera Barat
Authors: Arham Qumil Laila , Saputra Rahmad , Defaz Febriyan Pratama
Published: June 2023

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana citra merek produk kuliner rendang di Sumatera Barat. Penelitian ini menggunakan analisis kajian literatur dengan sumber seperti Sciencedirect, Researchgate, dan Google Scholar. Artikel yang dianalisis berjumlah sepuluh artikel. Kajian literatur juga dilakukan pada berbagai sumber buku dan sumber internet. Hasil penelitian menunjukkan bahwa brand image berdampak positif terhadap produk kuliner rendang di Sumatera Barat. Kuliner rendang juga memiliki nilai pendidikan dan nilai filosofis. Hasil penelitian kajian literatur ini menunjukkan bahwa brand image pada produk kuliner rendang dapat ditingkatkan dengan promosi dan peningkatan nilai produk agar tercipta kepuasan dan loyalitas pelanggan.
Hubungan masa kerja, postur kerja dan beban kerja fisik dengan keluhan musculoskeletal disorders (MSDs) pada pekerja industri genteng di desa Sidoluhur Sleman
Authors: Aprillia Puput , Rifai Muchamad
Published: June 2023

Latar Belakang: Keluhan Muskuloskeletal adalah keluhan yang berada pada bagian otot skeletal atau otot rangka yang dirasakan oleh seseorang mulai dari keluhan sangat ringan hingga sangat sakit. Apabila otot menerima beban statis secara berulang dan dalam jangka waktu yang cukup lama maka akan dapat menyebabkan keluhan berupa kerusakan pada sendi, ligamen dan tendon. Menurut data Labour Force Survei (LFS) Great Britain tahun 2017 kasus musculoskeletal disorders menempati urutan kedua dengan rata-rata prevalensi 469.000 kasus atau 34,54% selama tiga tahun terakhir dari semua kasus penyakit akibat kerja yang ada. Keluhan yang dialami pekerja sentra industri genteng terjadi karena aktivitas yang dilakukan secara berulang dan dalam jangka waktu yang lama. Postur kerja yang tidak baik dengan beban kerja yang berlebih menjadikan faktor utama adanya kejadian keluhan Musculoskeletal Disorders.
Metode Penelitian: Jenis penelitian ini adalah penelitian kuantitatif dengan rancangan penelitian cross sectional. Sampel pada penelitian ini berjumlah 48 orang. Teknik sampling yang digunakan dalam penelitian ini adalah Probability Sampling. Instrumen yang digunakan untuk menganalisis postur kerja dengan kejadian keluhan Musculoskeletal Disorders (MSDs) adalah lembar Rapid Entire Body Assessment (REBA) dan untuk melihat keluhan Musculoskeletal Disorders (MSDs) menggunakan lembar Nordic Body Map (NBM). Analisis data dengan Uji Chi-Square.
Hasil: Analisis bivariat menunjukan ada hubungan antara masa kerja dengan keluhan MSDs pada pekerja Sentra Industri Genteng Desa Sidoluhur, Kecamatan Godean, dengan nilai p value sebesar 0,005 (p value <0,05). Kemudian hubungan antara postur kerja dengan keluhan MSDs pada pekerja Sentra Industri Genteng Desa Sidoluhur, Kecamatan Godean, dengan nilai p value sebesar 0,000 (p value <0,05). Begitupun hubungan antara beban kerja fisik dengan keluhan MSDs pada pekerja Sentra Industri Genteng Desa Sidoluhur, Kecamatan Godean, memiliki nilai p value sebesar 0,000 (p value <0,05).
Kesimpulan: Ada hubungan secara statistik antara masa kerja, postur kerja, dan beban kerja fisik dengan keluhan Musculoskeletal Disorders (MSDs) pada pekerja Sentra Industri Genteng Di Desa Sidoluhur, Kecamatan Godean, Kabupaten Sleman.
Faktor-faktor yang berhubungan dengan perasaan kelelahan kerja pada pekerja di CV. Sada Wahyu Kabupaten Bantul
Authors: Fataruba Indah Dzil Arsyi , Dwi Saptadi Julian
Published: June 2023

Latar Belakang: Kelelahan kerja merupaka kondisi utama disebabkan terjadinya kecelakaan, dan faktor kemampuan fisik yang lemah juga dapat mengurangi aktivitas kerja. Ada berbagai faktor kelelahan yang disebabkan oleh faktor internal yang berada di dalam tubuh seperti umur, jenis kelamin, ukuran tubuh, dan status gizi, sedangkan faktor eksternal berupa waktu kerja, kerja bergilir, dan istirahat. Hal ini sangat mengandalkan kemampuan fisik pekerja untuk melakukan pekerjaan agar sesuai dengan target hal itu dapat membuat pekerja mengalami lelah bekerja. Tujuan penelitian ini adalah untuk mengetahui faktor apa yang berhubungan dengan kelelahan kerja pada pekerja di CV. Sada Wahyu.
Metode: Penelitian ini menggunakan jenis penelitian kuantitatif observasi analitik, memakai rancangan cross sectional dan sampel pekerja 42 orang. Analisis data menggunakan uji chi square dan confident interval 95%. Alat penelitian menggunakan kuesioner IFRC, timbangan dan microtoice.
Hasil: Hasil untuk analisis univariat dalam penelitian ini yaitu umur tua 27 orang (64,3%), jenis kelamin perempuan 25 orang (59,5%), masa kerja lama 25 orang (59,4%), status gizi overweight 22 orang (53,4%), dan kelelahan kerja tinggi 23 orang (54,8%). Hasil analisis bivariat yang didapatkan yaitu ada hubungan antara umur (p value 0,016 < α 0,05), masa kerja (p value 0,008 < α 0,05) dan status gizi (p value 0,006 < α  0,05). Tidak ada hubungan antara jenis kelamin dengan kelelahan kerja (p value 0,904 > α 0,05).
Kesimpulan: Ada hubungan antara umur, masa kerja dan status gizi dengan kelelahan kerja. Tidak ada hubungan antara jenis kelamin dengan kelelahan kerja.
FOME DE PODER: UM OLHAR PARA O PROCESSO DECISÓRIO NAS FRANQUIAS À LUZ DAS TEORIAS DE CUSTOS DE TRANSAÇÃO E NEOINSTITUCIONAL
Authors: Carvalho Alexsandre Gustavo da Silva , Resende Débora Dias , Mendonça Fabrício Molica de , Araújo Uajará Pessoa
Published: June 2023

Neste artigo propõe-se averiguar como as teorias de custos de transação e a teoria neoinconstitucional influenciam e se tornam presentes na tomada de decisões das redes de franquia de fast food. Para tanto, realizou-se uma análise do filme Fome de Poder- que trata da origem do McDonald’s. As decisões realizadas nessa franquia mostraram-se assertivas, ao longo do tempo, consolidando-a, expandindo-a e tornando-a referência mundial. Entretanto, ao analisar a origem do McDonald’s, desde o seu processo de edificação, enquanto franquia até o seu apogeu, tornou-se possível realizar reflexões sobre os papéis do franqueado e franqueador, a importância do contrato de transação e a influência das instituições e das práticas legitimadas. O artigo enriquece e diversifica a literatura acadêmica sobre o tema franquia, entrelaçado ao processo decisório, à teoria de custos de transação e à teoria neoinstitucional.
DETERMINANTES DO USO DE CRÉDITO NO BRASIL: UM ESTUDO A PARTIR DA PESQUISA DE ORÇAMENTOS FAMILIARES DE 2017/2018
Authors: De Góes Reis Raphael Roberto , Davanzo Eloá Sales
Published: June 2023

O objetivo do presente estudo é identificar os determinantes da demanda por crédito no Brasil através de variáveis da Pesquisa de Orçamentos Familiares (POF) 2017/18. Para isso, um modelo de regressão logística (logit) foi aplicado considerando características socioeconômicas e demográficas dos indivíduos. Os resultados sugerem que a posse do cartão de crédito é um dos principais fatores que aumentam a probabilidade do uso de crédito no país e que, no geral, não houve mudança expressiva nas variáveis que explicam o uso desse recurso financeiro nos últimos dez anos. O entendimento da relevância do cartão de crédito na demanda por crédito é importante, dado que ele é também o principal componente do endividamento das famílias no Brasil.
A review of the Masquelet technique in the treatment of lower limb critical-size bone defects
Authors: Ahmed H , Shakshak M , Trompeter A
Published: June 2023

The need for bone tissue to heal effectively is paramount given its role in the mechanical support of tissues. Bone has a very good natural healing potential in comparison with most other tissue types, largely regenerating to its pre-injury state in the vast majority of cases. Certain factors such as high energy trauma, tumour resection, revision surgery, developmental deformities and infection can lead to the formation of bone defects, where the intrinsic healing potential of bone is diminished owing to bone loss. Various approaches to resolving bone defects exist in current practice, each with their respective benefits and drawbacks. These include bone grafting, free tissue transfer, Ilizarov bone transport and the Masquelet induced membrane technique. This review focuses on evaluating the Masquelet technique, discussing its method and underlying mechanisms, the effectiveness of certain modifications, and its potential future directions.
A TRANSFORMAÇÃO METONTOLÓGICA DA ONTOLOGIA FUNDAMENTAL E A IDEIA DA FORMAÇÃO DE MUNDO
Authors: Rodrigues Fernando
Published: June 2023

Na preleção sobre Leibniz do verão de 1928 Metaphysische Anfangsgründe der Logik im Ausgang von Leibniz (GA 26), Heidegger defende a transformação metafísica da ontologia fundamental. Essa transformação é levada a cabo por meio de uma investigação temática denominada metontologia, cujo objeto é o caráter de ser-vinculado do Dasein humano ao ente como totalidade ôntica. Numa unidade temática, ontologia fundamental e metontologia constituem a metafísica do Dasein. No que segue, delineia-se o caminho para uma apropriação positiva dessa metafísica. Ela culmina, como será mostrado, numa hermenêutica do vínculo (Bindung), uma investigação que visa a pôr em relevo a essência do homem como formador de mundo, como dinâmica de liberdade e de vínculo.
DOSSIÊ WITTGENSTEIN E AS INVESTIGAÇÕES FILOSÓFICAS, 70 ANOS: RECEPÇÃO E IMPACTOS
Authors: De Jesus Nascimento André , Leitão Condé Mauro Lúcio , Teles de Oliveira Wagner
Published: June 2023

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APRESENTAÇÃO DE “AS INVESTIGAÇÕES FILOSÓFICAS DE WITTGENSTEIN”, DE PAUL FEYERABEND
Authors: De Lacerda Abrahão Luiz Henrique , Velloso Rafael
Published: June 2023

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Bioprecariedad. El poder de las patentes y su impacto en la salud pública
Authors: Jimeno Ramírez Sonia
Published: June 2023

El objetivo del presente artículo es analizar el poder de las patentes y su papel en la confrontación actual entre el derecho a la salud (pública) y los derechos a la propiedad intelectual (patentes), ambos reconocidos por la Declaración Universal de Derechos Humanos. Este poder se basa en el control monopolístico de material biológico mediante las patentes biotecnológicas o “patentes de la vida”. La Oficina Española de Patentes y Marcas define las patentes como “un título que reconoce el derecho de explotar en exclusiva una invención, impidiendo a otros su fabricación, venta o utilización sin consentimiento del titular”. Este monopolio permite establecer precios elevados a los productos patentados, condenando a miles de personas a lo que denominamos “bioprecariedad” entendida como la violencia estructural contra la vida por la falta de acceso a productos patentados básicos para la supervivencia (vacunas, semillas, medicamentos, tratamientos o kits de diagnóstico). En el escenario de la pandemia del Covid-19, la Bioprecariedad ha sido la protagonista, especialmente en el desigual reparto de las vacunas entre países ricos y países pobres. Nuestra propuesta es crear un marco normativo y comités de ética de patentes que sirva para poner límites éticos a las patentes según los criterios de responsabilidad y cautela; justicia global; y capacidades y desarrollo humano.
Bioética en contextos pluriculturales: problemas epistemológicos y su relación con los derechos humanos
Authors: Guerrero Sotelo Roxana Nayeli , Orellana Centeno José Eduardo , Juárez Pérez Melecio Honorio , Ramírez García Sergio Alberto
Published: June 2023

El objetivo de la investigación es identificar los problemas epistemológicos que surgen en el conocimiento y praxis de la Bioética en contextos pluriculturales y multiétnicos como es la Sierra Sur de Oaxaca México, y determinar su relación con los derechos humanos específicamente con el Enfoque de salud basado en los Derechos Humanos (EBDH). El método es el realismo epistemológico pragmático de Jürgen Habermas. Los resultados muestran dos tipos de problemas: el primero, es el tipo de relación sujeto-objeto de conocimiento en el que el Otro es subjetivado como objeto e instrumentalizado; y el segundo, el reduccionismo metodológico y por tanto las formas de verificación de las proposiciones verdaderas. Por cuanto hace a los derechos humanos vinculados a los problemas epistemológicos son principalmente colectivos y secundariamente individuales, en tanto que el proceso de conocimiento es un fenómeno social, comunal e histórico. Concluimos que la pluriculturalidad es un fenómeno que complejiza y enriquece la labor de la Bioética con una realidad múltiple de tipo sensible, inteligible y valorativo, este nexo muestra la necesidad de desarrollar abordajes inter o transdisciplinarios que aminoren tanto los problemas epistemológicos como la incidencia en la violación de derechos humanos.
El derecho fundamental a eutanasia y su problemática constitucional en España
Authors: Ruiz-Rico Ruiz Catalina
Published: June 2023

Tras la regulación de la eutanasia emerge una problemática constitucional y bioética que revela las deficiencias, lagunas y conflictos jurídicos sin resolver por la LO 3/2021, de 24 de marzo (LORE). La desprotección de colectivos vulnerables, la huida de las garantías jurídicas convencionales y la lesividad de derechos fundamentales, entre otras razones, fundamentan la dimensión constitucional del derecho a morir. El control jurídico de la eutanasia se enfrenta en la actualidad a su construcción legal como derecho fundamental pese a la apariencia como derecho prestacional de “ayuda a morir”, en base a la conexión con el derecho a la vida, integridad física y moral, dignidad, libertad, intimidad (Exposición de Motivos LORE). Sin embargo, desde una perspectiva constitucional, resulta insatisfactoria la exclusión de menores y sujetos sin capacidad de su ámbito subjetivo y el riesgo de eludir la ponderación en conflicto con otros derechos al adoptar una jerarquía superior de hecho.
Optical coherence tomography-based design for a real-time motion corrected scanning microscope
Authors: Tucker Stephen S. , Giblin John T. , Kiliç Kivilcim , Chen Anderson , Tang Jianbo , Boas David A.
Published: June 2023

While two-photon fluorescence microscopy is a powerful platform for the study of functional dynamics in living cells and tissues, the bulk motion inherent to these applications causes distortions. We have designed a motion tracking module based on spectral domain optical coherence tomography which compliments a laser scanning two-photon microscope with real-time corrective feedback. The module can be added to fluorescent imaging microscopes using a single dichroic and without additional contrast agents. We demonstrate that the system can track lateral displacements as large as 10 μm at 5 Hz with latency under 14 ms and propose a scheme to extend the system to 3D correction with the addition of a remote focusing module. We also propose several ways to improve the module’s performance by reducing the feedback latency. We anticipate that this design can be adapted to other imaging modalities, enabling the study of samples subject to motion artifacts at higher resolution.
Generation of low-frequency radiation under the effect of an ultrashort laser pulse on a semiconductor in a magnetic field
Authors: Grishkov Vyacheslav E. , Uryupin Sergey A.
Published: June 2023

One of the scenarios for the generation of THz radiation under the effect of a femtosecond laser pulse on a semiconductor in a magnetic field is proposed and studied in detail. It is shown how spectral composition, shape of the pulse, and total energy of the THz pulse change as the magnetic field increases. Explicit dependencies of the THz radiation features on the parameters of the laser pulse and the semiconductor are determined.