bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemoinformatic study of spiramycin in comparison with other antibiotics
Authors: Gromovа O. A. , Torshin I. Yu.
Published: February 2025

Background. Antibiotics have different spectra of action on bacterial pathogens, including their antibiotic-resistant strains. Establishing the spectra of action of antibiotics and mechanisms of resistance to them is an important task for finding effective and safe antibiotic therapy.

Objective: a chemoinformatic study of the macrolide spiramycin in comparison with moxifloxacin, josamycin, azithromycin and clarithromycin.

Material and methods. The analysis was carried out using modern data analysis methods (theories of labeled graph analysis, metric data analysis, combinatorial solvability theory, topological theory of ill-formalized problem analysis) developed within the framework of the algebraic approach to recognition.

Results. Chemomicrobiome and pharmacoinformatic profiling of spiramycin indicated significant differences between the spiramycin molecule and the comparison molecules in terms of efficacy, safety and mechanisms of action. Characteristic features of spiramycin action were inhibition of protein synthesis by influencing the ribosome, with possible inhibition of bacterial topoisomerase, DNA synthesis and with anti-membrane activity, including through ionophore mechanisms. Analysis of correlations between chemogenomic profiles of molecules indicated a pronounced similarity of the effects of three of the five studied molecules (josamycin, azithromycin, clarithromycin) with a significant difference in the effects of spiramycin from the effects of other studied macrolides. Mechanisms of resistance to spiramycin potentially include genes from the functional groups “assembly of the outer membrane of gram-negative bacteria”, “sorbitol transport”, “transmembrane transporter of L-leucine” etc. Spiramycin was characterized by the best safety profile in terms of “antimicronutrient” effects (increase in the risk of excretion of a particular micronutrient by only 7%).

Conclusion. The significant difference between the chemogenomic, chemomicrobiomic and pharmacoinformatic profiles of spiramycin and other antibiotics (including other macrolides) suggests low resistance to spiramycin at the population level.
Новые подходы к дизайну шекспировского костюма для кино и сцены (на примере экранизации комедии «Укрощение строптивой»)
Authors: Калько Ольга Викторовна
Published: February 2025

В статье рассматриваются аспекты эскизирования костюмов персонажей для театральных постановок или экранизаций классики мировой литературы. Обосновывается феномен популярности произведений известного английского драматурга В. Шекспира и актуальность адаптаций его комедий на экране и театральной сцене. Освещаются этапы эскизного проектирования исторических костюмов. Для данной цели проводится анализ модных силуэтов и конструктивно-декоративных форм европейских костюмов эпохи Возрождения, также выделяются особенности итальянского женского костюма на основе исторической модели-аналога. Основываясь на полученных данных, необходимо создать мудборд (от англ. mood board), так называемую «доску вдохновения», в качестве одного из ключевых этапов эскизного проекта. Предлагаются авторские эскизы костюма главной героини комедии В. Шекспира - технические и в цвете, которые выполнены в современном графическом редакторе — Adobe Illustrator. Освещается процесс преобразования исторических форм одежды в современные модели одежды для кино, театра и других сценических действий.
Метафизика социального бытия в «Столпе и утверждении Истины» П. А. Флоренского
Authors: Безменщиков Артем Евгеньевич
Published: February 2025

В статье производится краткий анализ социальной философии П. А. Флоренского как возможной и эвристически значимой интерпретации практико-философской составляющей его концепций. Объектом исследования является работа «Столп и утверждение Истины», предметом — понятийный строй подобной интерпретации и некоторые результаты проистекающего из нее анализа метафизики социального бытия в данном сочинении. В частности, впервые внимание сконцентрировано на том, как именно гносеологически ориентированный подход Флоренского к проблемным пересечениям экзистенциального и метафизического дискурсов в трактовке индивидуального и социального бытия дает ему возможность сделать сознание (или разум) парадигматическим основанием онтологии. Также религиозно-философский концепт «Любви» как божественной энергии переведен в социально-философский контекст и рассмотрен как экзистенциал коллективного бытия. Именно этот экзистенциал в качестве репрезентации метафизической сущности Бога-Истины кладется Флоренским в основу описываемой динамики консолидации преображенных индивидов и общностей. В целом традиционная для русской религиозной философии софиология Флоренского, таким образом, предстает как метафизика социального бытия. Исследование произведено на основании историко-философского и герменевтического типов анализа процесса, логики и результатов размышлений автора «Столпа». Характер получаемых результатов позволяет говорить о понятийной структуре социальной утопии, по отношению к которой «Столп» является теоретическим этапом, формирующим как базовые концепты автора и пути их дальнейшего практического применения, так и авторский оптимизм по отношению к возможностям социальной эпистемологии и социального проектирования.
Некоторые фундаментальные направления Российского проекта цивилизационного развития и цивилизационные основы России
Authors: Горелов Анатолий Алексеевич
Published: February 2025

Рассматриваются некоторые фундаментальные направления Российского проекта цивилизационного развития (РПЦР) в их взаимосвязи и целостности. Многополярная гармония, а не просто сосуществование многих государств является внешнеполитическим выражением социальной справедливости на уровне взаимоотношений между государствами, которая, в свою очередь, распространяется в плане устойчивого развития на взаимоотношения человека с природной средой его обитания. Эти взаимосвязанные нити обеспечивают целостность глобальной системы.

Условия формирования и осуществления РПЦР — эволюционный императив как любовь и единство человека со средой его обитания. Указанные направления основываются на важнейших концепциях русской философской мысли — концепции соборности А. С. Хомякова и концепции русского социализма Ф. М. Достоевского. Обе эти концепции также внутренне связаны между собой. Концепция соборности представляет собой совокупность способов управления какими-либо объединениями с помощью общего свободного обсуждения возникающих проблем и единогласного решения. Концепция русского социализма, по Достоевскому, утверждает братство всех людей во Христе. Именно это на сущностном уровне обеспечивает единство и внутреннюю целостность РПЦР и позволяет надеяться на его успешное осуществление.
Синтезирующая роль концепций соборности и русского социализма дает возможность рассматривать РПЦР не как самостоятельный законченный проект, а как путь в направлении воплощения в жизнь идеалов соборного русского социализма. Для осуществления столь масштабного проекта необходимы вера, надежда, любовь, мудрость, политическая воля и творческий подъем. Осуществление этих задач требует от каждого человека ежедневного и убежденного участия в созидании при условии, что общественность будет играть известную роль в определении политики.
Значение концепта «государство-цивилизация» для идеологической доктрины
Authors: Горелова Татьяна Анатольевна
Published: February 2025

В статье рассматривается понятие «государство-цивилизация» в концептуальном смысле. Концепт как сложный лингвосоциальный конструкт включает три уровня — понятийный, образный и ценностный. Предлагаемая структура концептосферы помогает структурировать концепт и проследить его временную динамику как на этническом (макроконцептосфера), в котором запечатлены ее ценностные смыслы, так и на индивидуальном уровне (микроконцептосфера), который отражает ценности отдельных индивидов.

Понятие «государство-цивилизация» относительно новое (Ф. Бродель). Объединение двух понятий — «государство» и «цивилизация» — становится плодотворным для описания форм существования современных наций. Наше время явно сделало выбор в пользу государства как способа уравновешивания частной свободы и общего блага: модель правового государства стала общечеловеческой. Идея «революции как фактора цивилизационного развития» (Ш. Эйзенштадт) — это многофакторная концепция, утверждающая возможность конвергенции институциональных и духовных структур различных обществ с современностью при сохранении их цивилизационной специфики. Образом структуры государства-цивилизации является сфера, обладающая ядром и целым спектром цивилизационных оболочек, охватывающих всю совокупность человеческих практик — духовных, культурных, общественно-социальных, технологических. Ценностный уровень «государства-цивилизации» составляют базовые ценности ядра цивилизации, которые каждому из семи обозначенных государств-цивилизаций предстоит в себе раскрыть, и суверенитет, составляющий основу государственности.

Делается вывод, что преимущества концепции государства-цивилизации по сравнению с другими теоретическими подходами состоят в нацеленности на осознанный отказ от однополярности и системы глобального неоколониализма, выстраиваемой Западом; в призыве к народам и их интеллектуальным элитам искать выход не по указке извне, а в духовных глубинах собственной культуры; в признании исторической глубины, субъектности и равноправия цивилизационных центров мира; в осознании значения культурно-цивилизационных факторов для международной политики, где сталкиваются не только интересы, но и идентичности; в признании идеи синергии и коэволюции цивилизаций как составной части общей концепции коэволюции природы и общества.
О трудной проблеме сознания. Часть I
Authors: Олейников Юрий Васильевич
Published: February 2025

В первой части статьи основное место уделено рассмотрению социально-культурной концепции природы и сущности сознания в их связи с философской проблемой идеального, истоки разработки которых можно обнаружить еще в античной философии. Возникновение и функционирование сознания и формирование особого идеального мира рассматривается в контексте антропосоциогенеза, в ходе которого стали реальностью современный человек, общество, как способ существования сознательных существ, и в целом в земном планетарном социоприродном Универсуме сформировалась социальная форма движения материи. Истоки появления новой социальной формы бытия связываются с появлением целесообразной трудовой деятельности, благодаря которой возникла потребность в координации жизнедеятельности становящегося человека и общества и всех связанных с этим атрибутов: языка, мышления, сознания и, собственно, идеального или идеального мира, как особой нематериальной формы деятельности.
У истоков проблемы равенства. Часть III
Authors: Канарш Григорий Юрьевич
Published: February 2025

Данный текст является заключительной частью статьи о равенстве — первые две части были опубликованы в предыдущих номерах журнала «Знание. Понимание. Умение» (2024. № 1, 2). В этой большой трехчастной статье мы исследовали становление политического концепта равенства — от древнейших времен до конца XVIII в. В данной, третьей (и заключительной) части статьи мы изучим представления о равенстве в социальной и политической мысли французского Просвещения. Надо отметить при этом, что эта эпоха (Просвещение) имеет огромное значение, поскольку именно с нее начинается становление «проекта Современности» как такового. Мысли и идеи, высказанные в этот период разными мыслителями, не только подготовили почву для Французской революции, но и задали направление для развития социальной и политической философии на два века вперед. Именно в этот период (но, конечно, основываясь, в свою очередь, на фундаменте предшествующего, XVII столетия) формулируются идейные основания будущих «великих идеологий» Современности — либерализма, консерватизма и социализма. И концепт равенства (как и свободы, тесно связанный с последним) занимает в этих учениях центральное место.
Optimizing oral health and function with telescopic dentures: A case report in preventive prosthodontics
Authors: Saravanakumar Prathibha , Selvam Divyabharathi
Published: February 2025

Preventive prosthodontics is a crucial field within prosthetic dentistry aimed at conserving natural teeth and surrounding oral structures to prevent further deterioration. This approach emphasizes early intervention to maintain oral health, function, and aesthetics while minimizing the need for extensive future treatments. This case report explores the application of preventive prosthodontics through the use of telescopic dentures in a 59-year-old female patient with diabetes. The patient presented with a dislodged fixed partial denture (FPD) and multiple compromised abutment teeth. After assessing her condition, including significant periodontal issues and missing teeth, a treatment plan incorporating a telescopic denture was chosen. The telescopic denture system, featuring dual copings, provided superior retention and stability while preserving natural teeth and bone structure. The treatment involved careful tooth preparation, periodontal therapy, and the fabrication of telescopic copings and crowns. The patient reported significant improvements in masticatory function, stability, and comfort. The case demonstrates how telescopic dentures offer a high-quality solution in preventive prosthodontics, combining the advantages of both fixed and removable prostheses to address complex clinical situations effectively.
Post-surgical rehabilitation of squamous cell carcinoma with finger prosthesis: A case report
Authors: Vasudevan Karthikeyan , Rose Angel , Reddy Vishal , Selvam Divyabharathi , Balasubramaniam Muthukumar
Published: February 2025

Squamous cell carcinoma (SCC) of the finger can lead to both functional and aesthetic impairments, particularly when surgical excision and radiotherapy result in finger amputation. This case report presents the rehabilitation of a 55-year-old male, Mr. Ramamurthy, who lost his fourth finger due to SCC. Following wide local excision (WLE) and radiotherapy, a custom silicone prosthesis was designed to restore both the appearance and functionality of his right hand. The fabrication process included shade matching, texture replication, and a focus on providing passive functionality for daily tasks. The patient reported significant improvement in self-confidence and functional ability, although challenges such as limited dexterity and the potential need for prosthetic replacement over time were noted. Despite the limitations of silicone prostheses, the case highlights the positive impact of personalized prosthetic solutions on both physical function and psychological well-being, significantly improving the quality of life for patients recovering from SCC-related finger amputation.
Desarrollo sostenible de la agricultura en América Latina y el Caribe: desafíos y oportunidades
Authors: De Salvo Carmine Paolo , Salazar Lina , González Mario , Schling Maja , Muñoz Gonzalo , Rondinone Gonzalo , Le Pommellec Marion
Published: February 2025

Este documento examina los desafíos y las oportunidades significativas para el sector agrícola en América Latina y el Caribe (LAC). Destaca el papel central del sector para abordar tres prioridades interconectadas: garantizar la seguridad alimentaria para una población creciente, aumentar los ingresos agrícolas mientras se refuerza la resiliencia climática, y reducir la huella ambiental de las prácticas agrícolas. El documento ofrece un análisis detallado del estado actual de la agricultura en la región, enfocándose en temas como la pobreza rural, el estancamiento de la productividad y los impactos del cambio climático. Basándose en evidencias de experiencias internacionales y lecciones de las operaciones del Grupo BID, el documento evalúa la efectividad de diversas políticas agrícolas para mejorar la seguridad alimentaria, fomentar el crecimiento de los ingresos y lograr la sostenibilidad ambiental. Identifica barreras clave, como la infraestructura inadecuada, la insuficiente inversión en investigación e innovación, las prácticas agrícolas insostenibles y las desigualdades de género y étnicas. Además, el informe destaca la necesidad de una acción transformadora para fortalecer las instituciones, promover tecnologías resilientes al clima y apoyar prácticas agrícolas ambientalmente sostenibles. Para abordar estos desafíos, el documento propone un enfoque integral organizado en torno a líneas de acción específicas y transversales, con el objetivo de construir un sector agrícola productivo, sostenible e inclusivo en LAC. Estas recomendaciones enfatizan la importancia de la generación de conocimiento, el fortalecimiento institucional y las políticas enfocadas en bienes públicos para impulsar el desarrollo sostenible de la agricultura, al mismo tiempo que contribuyen a los objetivos socioeconómicos más amplios.
Breaking Glass Ceilings in Colombia: Strategies and Outcomes in Efforts to Narrow the Gender Gap in Educational Leadership
Authors: Elacqua Gregory , Pérez-Nuñez Graciela , Cubillos Pedro P. , Iglesias Velasco Juliana
Published: February 2025

In Colombia, women represent 65% of the teacher workforce but only 34% of school principals, reflecting a significant gender gap in leadership. This study examines two centralized principal selection processes implemented by Colombias National Civil Service Commission: the 2016 nationwide process and the 2018 process targeting disadvantaged PDET regions (Development Programs with a Territorial Focus). Both processes evaluated candidates through standardized tests, minimum requirements, and assessments of education and experience, determining eligibility for leadership vacancies. Our descriptive analysis shows how selection criteria influence gender representation. In 2016, standardized testing dominated, resulting in 45% of applicants being women but only 20% qualifying, with an overall eligible-to-vacancy ratio of just 0.7%. In contrast, the 2018 PDET process prioritized context-specific competencies and practical experience, yielding 35% female eligibility despite women comprising only 38% of applicants (likely due to challenging conditions in PDET regions). Moreover, eligible candidates of both genders outnumbered vacancies by 4.5 times. These findings underscore the critical role of selection design in shaping gender representation in school leadership. However, structural barriers, such as inadequate childcare and rigid work schedules, persist as obstacles to womens participation
THROUGH THE RUINS TO A DEAD END: THE CREATIVE LIFE OF SAMARA ARTISTS IN THE POST-WAR PERIOD (1946-1953S)
Authors: Anshakov Evgeny
Published: February 2025

The article explores the activities of the Kuibyshev branch of the Union of Soviet Artists (KSSH) in the post-war period (1946-1953), focusing on the problems faced by the artistic community at that time. Despite attempts at reform, the KSSH found itself in a critical situation due to a lack of resources, lack of proper support from the authorities, lack of exhibition space and aging staff. This led to a decrease in the quality of work, lagging behind other regions and an unsatisfactory creative climate in Kuibyshev. As a result, by 1953, the KSSH had not been able to overcome the current crisis.
THE ACTIVITIES OF EMPRESS MARIA ALEXANDROVNA AND THE SMOLENSK BRANCH OF THE RED CROSS
Authors: Dmitrachkova Alla
Published: February 2025

The article examines the history of the founding of the Russian Red Cross Society, as well as the role of Empress Maria Alexandrovna in the formation and development of this organization. In the course of the study, the author also highlights the regional aspect based on data on the establishment of the Red Cross in the Smolensk province. The author comes to the conclusion that Maria Alexandrovna's activity was aimed at the development of this society: She took part in the opening of hospitals, had a hand in creating the symbols of the organization, personally selected its members, and also spoke on behalf of all its participants, thereby showing the importance and seriousness of the organization's activities.
Actor Interaction in the Process of Formulating Cultural Promotion Policies in Lubuklinggau City
Authors: Aminudin Achmad , Yogoprayitno Jatmiko , ‎ Sartika
Published: February 2025

Promoting culture is an important issue in the era of globalization, especially at the regional level, such as Lubuklinggau City, where the preservation of local cultural identity faces the current modernization. For this reason, the Lubuklinggau City government formed a regional promotion policy to face these challenges. This research aims to analyze the interaction between actors in formulating cultural promotion policies in Lubuklinggau City, revealing the dynamics of power and the roles of various stakeholders. Using a descriptive qualitative approach, this research involved in-depth interviews, participatory observation, and document analysis for 5 months, with data processing techniques using the Miles and Huberman interactive model. The results showed a complex pattern of vertical and horizontal interactions, reflecting the power distribution that extends beyond formal institutions. The role of mediators and facilitators, particularly the team of academics and DPRD members, was crucial in bridging the diverse interests. However, this process faces coordination and synchronization challenges, especially in aligning priorities and integrating cultural policies with other sectors. Based on these findings, it is recommended that coordination mechanisms between stakeholders be strengthened, regional cultural thoughts be developed, institutional capacity be improved, and a more holistic and collaborative approach to cultural policy formulation be adopted.
Policy Formulation for Organizing Archives in Lubuklinggau City
Authors: ‎ Nursanty , Azhari Fariz Atonius
Published: February 2025

The formation of a policy on archiving in Lubuklinggau City is the government’s response to the urgency of structuring a comprehensive and integrated archiving system. Currently, this policy is still being drafted. Therefore, this paper aims to examine policy formulation using a goal-oriented model. A qualitative-descriptive approach collected data through in-depth interviews with key stakeholders, direct observation of archival practices, and documentation studies of relevant regulations. The results show that policy formulation focuses on providing legal certainty, ensuring the availability of authentic archives, and improving the quality of archival services. Meanwhile, the resource analysis revealed gaps between ideal needs and actual conditions, especially in human resources and infrastructure. Furthermore, the formulated policies include establishing a Regional Archives Institute, developing archival human resources through continuous training, standardizing dynamic and static archive management, and implementing an electronic archive system through SRIKANDI. This comprehensive approach is expected to increase the effectiveness of archiving in Lubuklinggau City and overcome the challenges reflected in the category C (Less) assessment in the 2022 Regional Level National Archives Supervision Report. This paper provides insight into the archival policy formulation process at the regional level and can serve as a reference for the development of similar policies in other regions.
Collaborative Governance in Developing Child-friendly Cities
Authors: Novaria Rachmawati , Handoko V. Rudy , Sukristyanto Agus , Sunyoto Kodrat , Rahmadaniko Dida , Danumaya Aditya
Published: February 2025

Community-based integrated child protection is a movement of networks or groups of citizens at the community level that work in a coordinated manner to achieve child protection goals. The legal basis for its formation is related to child protection contained in the convention on the rights of the child, Law Number 35 of 2014 concerning child protection, the problem is that the participation between the community, local government, and nonstate organizations as well as between organizations in outside the government as government partners in realizing Child-friendly City (CFC). The aim is to identify and analyze collaborative governance that has been running, the roles of local governments, the business world, educational institutions, the mass media, and the community in developing child-friendly cities. Collaborative theory from Chris Ansell and Alisson Gash was used to explain collaborative governance in the development of child-friendly cities by looking at their roles as facilitators, coordinators, stimulators, and dynamics. The data were obtained from informants and was quasi qualitative. The recommendation: it is necessary to have integrated community-based child protection, the configuration of resources from various organizational backgrounds that join in a forum, co-ordination, and diversification of communication media, which is carried out to support activities to fulfill children’s rights.
Five-dimensional Analysis of Gastrodiplomacy of the South Korean Government
Authors: Yuniningsih Tri , Larasati Endang , Suwitri Sri , Hidayati Rizki , Mangai Mary
Published: February 2025

The South Korean government chose gastrodiplomacy to attract people’s sympathy. Popularly, Korean Wave is used as an attraction in marketing products, both cultural and commercial, as well as supporting the South Korean tourism industry on an international scale. This research aims to analyze the South Korean Government’s gastrodiplomacy strategy from the 5 K dimensions (K-Pop, K-Fashion, K-Food, K-Drama, and K-Beauty). This research uses a qualitative descriptive research method. The research results show that the five dimensions above have been implemented well and provide benefits by increasing the number of tourist visits to South Korea. Government support has been crucial in launching various kinds of programs, including culinary, fashion, beauty, drama, and music. The Global Hansik Program impacted the South Korean economy, which is marked by an increase in the number of exports and the development of markets for South Korean agricultural and food products, especially in Southeast Asia. The Global Hansik program is part of South Korea’s soft power which takes advantage of the popularity of Hallyu and traditional Korean culture to spread it. The recommendations made are the need for the South Korean government to increase outreach about halal food for Muslim tourists and increase the provision of Muslim places of worship which are still relatively difficult to find.
Revisiting the New Public Administration Paradigm in Jokowi's Administration: A Systematic Literature Review
Authors: Wicaksono Kristian Widya , Simanjorang Jeffri Yosep , Haq Muhammad Hafizh Zhahirul , Anabelle Jovita
Published: February 2025

The current development of public administration is influenced by three main factors namely market pull, governance, and digitalization, which often distracts public administration observers from other fundamental aspects. This article intends to revisit the New Public Administration (NPA) paradigm that focuses on the goals of public administration namely relevance, value, change, and social justice by focusing on contemporary Indonesia. By conducting a systematic literature review of publications released in the last 10 years, this article analyses the discussion of articles that address the pillars of NPA, namely debureaucratization, democratization, delegation, and decentralization (4Ds). The article finds that while there has been significant progress in terms of economic and infrastructure development under President Joko Widodo ( Jokowi), there has been criticism about the lack of attention to democratic values and civil liberties. Efforts to strengthen governance and bureaucratic efficiency in Indonesia have often come at the expense of democratic principles and wider public participation, resulting in less space for civil liberties and tighter controls on dissent or criticism. From these findings, this article calls for a return to the views of scholars such as Frederickson, Crow, and Bryer who emphasize the importance of a more adaptive and value-based public administration design that involves citizen participation as a key component of the system.
The Effectiveness of Implementing the Integrated Dynamic Archival Information System (SRIKANDI) at the Ministry of Religion Office of Lhokseumawe City
Authors: ‎ Nurhafni , Ar Rahman Dahlan , Mardhiah Ainul , Fazril Muhammad , Bin Abu Bakar Muhammad , Fakhrurrazi Fakhrurrazi
Published: February 2025

This research examines the effectiveness of implementing the Integrated Dynamic Archiving Information System (SRIKANDI) at the Ministry of Religious Affairs Office in Lhokseumawe City. Based on efforts to realize a more effective and efficient government through the utilization of technology and informatics as mandated in Presidential Regulation of the Republic of Indonesia number 95 of 2018 concerning the electronic-based government system. Through the Circular Letter of the Secretary General of the Ministry of Religious Affairs Number 31 of 2022, SRIKANDI has been mandatory since December 1, 2022, aimed at supporting the Electronic-Based Government System (SPBE) by enhancing transparency, accountability, and efficiency in archive management. The research method used is the descriptive qualitative analysis method. Data collection was carried out through interviews, observations, and documentation. The research results show that there are four obstacles faced in the implementation of SRIKANDI. First, the low understanding and skills of employees in using the application; second, the lack of guidance and socialization from the leadership; third, the limitations of facilities and infrastructure; and fourth, the lack of coordination between work units. The efforts to achieve effectiveness include enhancing training, forming special teams, improving system reliability, and providing adequate facilities. This research concludes that although the implementation of SRIKANDI is not yet optimal, there are still several obstacles. Improvement and enhancement measures are continuously being carried out to achieve more efficient and transparent archive management in order to support the comprehensive implementation of SPBE.
Ideação Suicida em Adolescentes de uma Escola de Ensino Médio no Interior Cearense: Possíveis Motivações
Authors: Souza Vanessa Tavares de , Nascimento Cidianna Emanuelly Melo do
Published: February 2025

O fenômeno do suicídio é um problema de saúde pública mundial, chamando atenção para um aumento alarmante nas taxas de mortalidade de adolescentes. Objetivou-se investigar as possíveis motivações envoltas nos pensamentos suicidas em adolescentes de uma escola pública de ensino médio na cidade de Tauá, interior do Ceará. Pesquisa de natureza qualitativa realizada com seis adolescentes do gênero feminino (quatro) e masculino (dois), entre 15 e 17 anos. Foram utilizados como instrumentos e técnica: 1) Questionário sociodemográfico; e 2) Entrevista individual semiestruturada, concretizada em um encontro com cada adolescente. Na análise, foram discutidas as seguintes categorias: “Relações familiares: nuances entre motivações e proteção para a ideação suicida na adolescência”; “Outras possíveis motivações para os pensamentos de morte e os comportamentos suicidas diante da ideação”; e “Mecanismos de enfrentamento e fatores protetivos”. Nos resultados, foi observado que as relações familiares, instabilidade emocional, fatores estressores da vida cotidiana, bullying e tentativa prévia de suicídio foram considerados pelos adolescentes entrevistados como propagadores para que os pensamentos suicidas surjam. Os achados corroboram a importância desses jovens terem suporte psicológico, familiar e escolar para lidarem com as suas questões de forma mais funcional, agindo como fatores de proteção contra a ideação suicida.
Palavras-chave: adolescente; ideação suicida; escola; suicídio; saúde mental.
The Time to Progression in Lung Adenocarcinoma Patients Receiving First- and Second-Generation EGFR-TKI in Indonesia
Authors: Syahruddin Elisna , Soeroso Noni Novisari , Ananda Fannie Rizki , Wulandari Laksmi , Setijadi Ana Rima , Ermayanti Sabrina , Pratiwi Suryanti Dwi , Infianto Andreas , Andayani Novita , Munir Sri Melati , Pratama Avissena Dutha , Kusumawardani Ida Ayu Jasminarti Dwi , Haryati Haryati , Duyen Natalie , Hanif Muhammad Alfin , Lim Darren Wan-Teck
Published: February 2025

Introduction: Targeted therapy, particularly epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI), is the first-line treatment for non-small cell lung cancer (NSCLC). However, drug resistance has grown in the last few decades. This study compared the progression time of lung cancer patients treated with first- and second-generation EGFR-TKI.
Methods: Based on cytology and histological results, this cross-sectional study included 1,008 participants diagnosed with lung adenocarcinoma (LUAD) from 11 Indonesian Respiratory Centers. Every three months, the response to treatment was assessed using the Response Evaluation Criteria in Solid Tumours (RECIST) criteria in 1.1. Significant differences in the clinical features of the three TKI treatment groups were identified using logistic regression analysis, the median time to disease progression was estimated using the Kaplan-Meier technique, and independent prognostic factors related to the time to progression (TTP) were assessed using Cox proportional hazards regression.
Results: This study examined 505 patients, the majority of whom were females (50.9%), never smoked (59.8%), diagnosed at an advanced stage (99.2%), and had an Eastern Cooperative Oncology Group (ECOG) scale of 0-1 (83.2%). Approximately 98.1% of patients were treated with afatinib (14.8%), erlotinib (18.6%), and gefitinib (66.1%) due to common mutations. The groups did not differ significantly (p>0.05). The median overall survival (OS) rate was 9 months. The time to LUAD progression in lung cancer was significantly impacted by poor performance (p=0.001).
Conclusion: Epidermal growth factor receptor-tyrosine kinase inhibitor treatment can only prolong the TTP of LUAD by up to 9 months, and the performance scale when receiving the EGFR-TKI significantly affects the prognosis.
Anaplastic Lymphoma Kinase (ALK) Rearrangement of Lung Adenocarcinoma among North Sumatera Population
Authors: Putra Muhammad Yusuf Adira , Soeroso Noni Novisari , Syahruddin Elisna , Suzanna Evlina , Afiani Dina , Ashar Taufik , Lim Darren Wan-Teck
Published: February 2025

Introduction: Lung cancer is a malignancy of the lung parenchyma or bronchi. Molecular targeted therapy directed at oncogene driver mutations, such as anaplastic lymphoma kinase (ALK), improves the prognosis of patients with non-small cell lung carcinoma (NSCLC). This study aimed to determine the characteristics of lung adenocarcinoma patients and the prevalence of ALK rearrangement among the North Sumatra population.
Methods: This descriptive study used data from patients' formalin-fixed paraffin-embedded (FFPE) ALK examination results and medical records. The laboratory analyzed the patient’s FFPE for ALK fusion protein expression using the VENTANA anti-ALK (D5F3) procedure to determine the prevalence of ALK rearrangement.
Results: Of the 34 subjects, it was revealed that the characteristics of lung adenocarcinoma patients were 18 patients aged >60 years old (52.9%), 26 male patients (76.4%), and 24 heavy smoker patients (70.6%). Based on the pathological tumor-node-metastasis (pTNM) stage, most samples were classified as stage IVA, with 24 cases (70.6%) showing the highest metastases to the pleura. There were 2 cases of ALK mutations obtained through immunohistochemical examination with a percentage of 5.8%.
Conclusion: There are relatively few ALK rearrangement mutations in lung adenocarcinoma patients without screening. Additional research is needed to ascertain the distribution of lung adenocarcinoma patient characteristics associated with a higher prevalence of ALK rearrangement mutations.
Nutritional Status and Lung Cavity in Pulmonary Tuberculosis Patient
Authors: Hanafi Christi Giovani Anggasta , Nurwidya Fariz , Lestari Wiji , Agustin Heidy , Syam Shaogi
Published: February 2025

Introduction: As one of the leading causes of death worldwide, pulmonary tuberculosis (PTB) is an infectious disease that continues to pose a serious threat to public health. The presence of cavities in radiological imaging of patients with PTB is associated with malnutrition, age, gender, and other comorbidities, including diabetes mellitus. This study aimed to find the association between nutritional status and lung cavity in PTB patients.
Methods: This was an analytical observational study with a cross-sectional design that involved 134 adult patients who were diagnosed with PTB at Persahabatan National Respiratory Referral Hospital, Jakarta. All patients were interviewed using a questionnaire for sociodemographic and anthropometric data, the nutritional status was assessed using the subjective global assessment (SGA), and the lung cavity was determined using a chest X-ray interpreted by radiologists. The Chi-square test was performed using the Statistical Package for the Social Sciences (SPSS) version 25 for Windows.
Results: Of 134 PTB patients, 61.9% were males, and 92.5% were from the 18-59 years old age group. Based on the SGA score, 77 (57.5%) were grouped as mild-moderate malnutrition/SGA B and 22 (16.4%) as severe malnutrition/SGA C. Lung cavity was found in 42 (31.3%) patients. The analysis showed that malnutrition was statistically significantly associated with lung cavity with OR=6.933 (95%CI 1.986-24.205; p=0.002) and the adjusted OR were 7.303 (95%CI 2.060-25.890; p=0.002) after controlling for age, sex, smoking, education, and comorbidities.
Conclusion: This study found that malnutrition was associated with lung cavities in PTB patients. These findings might indicate how malnutrition impaired the immune function in PTB patients.
Perspective on neonicotinoid insecticides in human exposure and risk assessment
Authors: Song Shaofang , Yue Yuhan , Jiang Qiaoli , Li Chunqun , Zhang Hua
Published: February 2025

This perspective presents first-hand research insights into the pervasive environmental distribution of neonicotinoid insecticides (NEOs) and their consequent human exposure. Our findings reveal widespread NEO detection across human biological matrices, indicating potential health risks and highlighting critical gaps in current risk assessment paradigms. We identify an urgent need for longitudinal epidemiological studies, particularly focusing on vulnerable populations, to comprehensively assess NEO-related health outcomes. These scientific insights should inform evidence-based policy reforms and risk management strategies to effectively protect both public health and environmental integrity.
Determination of microplastics in municipal wastewater treatment plant effluents and sludge using micro-Raman spectroscopy
Authors: Miserli Kleopatra , Konstantinou Ioannis
Published: February 2025

Microplastics (MPs) increase global awareness due to their ubiquity, high concentration levels, and devastating effects on the aquatic environment. Wastewater treatment plants (WWTPs) are recognized as a significant source of microplastics in aquatic and terrestrial environments, particularly for plastics used in personal care products and textile fibers from the clothing industry. The focus of the present study was the determination of MP in wastewater and sewage sludge samples of WWTP of Ioannina city, according to their shape, size, concentration, and polymer type. A wet peroxide oxidation (WPO) method using 30% H2O2 and 0.05 M ferrous (II) solution was applied to the water effluent, while an enzymatic digestion method combined with WPO was employed to eliminate the organic matter and extract MPs from sludge samples. Micro-Raman spectroscopy coupled with appropriate software was applied to detect and quantify the microplastic particles. The outcomes from this study showed that the most representative shape of MP in effluent wastewater and sludge was fragments (66.7% and 75%, respectively), followed by fibers, spheres, and films. Polyamide (PA), p -acrylic acid (PAA), and p -acrylamide-co-p -acrylic acid (PAM-co-PAA) were the most abundant polymers (100% frequency of detection), followed by p -vinyl chloride (PVC), p -butyl methacrylate (PBMA), p -ethylene (PE), p -styrene (PS), p -propylene (PP), p -vinyl alcohol (PVA), and p -vinyl butyral (PVB) (20%-80% frequency of detection). The mean concentration of MPs in five sampling campaigns was 5.8 ± 0.6 particles/L in secondary WWTP effluents and 33.3 ± 8 particles/g in sludge. This study focused on monitoring campaign, in order to better understand the occurrence, impact, and risks associated with MPs on WWTPs.
Experience in Using Direct Magnetic Resonance Cholangiography and Fistulography in the Diagnosis of Cholelithiasis Complications and Postoperative Treatment for Choledocholithiasis
Authors: Volkov A. A. , Kononova A. О. , Belosel’skiy N. N. , Pribytkov Yu. N. , Pribytkov A. Yu.
Published: February 2025

The article presents four clinical observations of patients who underwent contrast-enhanced magnetic resonance imaging (MRI) after treatment for cholelithiasis complicated by choledocholithiasis. Abdominal MRI was performed using Amira 1.5T MR tomograph (Siemens, Germany) according to standard protocols with subsequent injection of contrast agent in the form of 20 ml of paramagnetic (Omniscan®) diluted in 50 ml of saline solution: in three patients – into the common bile duct drainage tubes, and in one patient – through a probe inserted into the fistulous tract of the anterior abdominal wall. It was shown that dilution of 20 ml of Omniscan® in 50 ml of saline solution to increase the volume of the contrast agent does not significantly affect MR properties of the paramagnetic. The technique allowed identifying the patency of extrahepatic bile ducts and showed high potential in detecting bile discharge as a complication of surgical treatment for choledocholithiasis, but it did not visualize directly the lumen of drainage tubes and fistula passages, which requires further improvement.
Using High-Intensity Focused Ultrasound in Clinical Oncology
Authors: Pan’shin G. A. , Nudnov N. V.
Published: February 2025

Traditional antitumor methods of special treatment for malignant neoplasms are open surgery, chemo- and radiation therapy, and, in recent years, immunotherapy. At the same time, they are associated with a number of unfavorable factors (primarily during the surgical stage of special treatment), such as long periods of patients’ hospital stay and subsequent recovery. One of the main goals of technological and medical research in the field of combating malignant neoplasms is to significantly reduce local, regional and systemic side effects compared with traditional methods of treatment and provide additional therapeutic opportunities in cases where traditional methods are ineffective. Not so long ago, relatively new methods of antitumor treatment have been introduced into clinical practice, such as radiofrequency, laser, microwave and cryoablation, and high-intensity focused ultrasound (HIFU), which is currently being intensively improved as a non-invasive method of treating a number of primary as well as recurrent solid tumors and metastatic diseases. The article presents in a quite brief form the stages of HIFU method formation, methodological aspects and physical foundations of HIFU therapy, as well as very positive results already achieved in clinical application of this method for the treatment of malignant tumors.
Revisión sistemática sobre características y eficacia de los programas preventivos escolares en drogodependencias en España
Authors: Villanueva-Blasco Víctor José , Medina-Martínez Jorge , Zaragoza Javier
Published: February 2025

El ámbito escolar adquiere una gran relevancia en la prevención del consumo de drogas en estudiantes, ya que es donde pasan una mayor parte del tiempo y, puesto que en España la enseñanza es obligatoria hasta los 16 años, las intervenciones en este ámbito pueden alcanzar a la mayoría de niños en esa etapa. El objetivo de esta revisión sistemática fue determinar qué nivel de eficacia presentan los programas preventivos escolares que se han implementado en España. Siguiendo las recomendaciones PRISMA, se llevó a cabo una búsqueda bibliográfica sistemática en las bases de datos Web of Science, PubMed/MEDLINE, Embase, Scopus y Cochrane Library. La búsqueda arrojó 274 estudios, de los cuales fueron seleccionados 29 estudios. Se ha identificado que en España se han implementado 48 programas preventivos en drogodependencias en el contexto escolar, de los cuales tan solo 18 (37,5%) cuentan con evaluación de su eficacia siguiendo los criterios y estándares de una prevención eficaz. Por el contrario, los programas que no han sido evaluados distan en su diseño de estos estándares. Se concluye que en España conviven dos modelos de prevención escolar de las drogodependencias: un modelo que responde a esta denominación; y otro modelo calificado como “pseudo-prevención”, dado que su diseño no se ajusta a los estándares de la prevención eficaz ni su eficacia preventiva ha sido demostrada.
¿Está disminuyendo el consumo de tabaco, alcohol y cannabis por los adolescentes?
Authors: Brime Begoña , Villalbí Joan R.
Published: February 2025

Editorial del volumen 35-4.
Linearized Expressions of 3D Rotational Motion
Authors: Liu Yinlong
Published: February 2025

Rotation motion in a three-dimensional physical world refers to an angular displacement of an object around a specific axis in $\mathbb{R}^3$. It is typically formulated as a non-linear and non-convex motion due to the nonlinearity and nonconvexity of $\mathbb{SO}(3)$. However, this paper proposes a new perspective that the 3D rotation motion can be expressed by a linear system without dropping any constraints and increasing any singularities. Moreover, two frequent cases, i.e., $\angle\left(\mathbf{R}\boldsymbol{x},\boldsymbol{y}\right)=0$ and $\angle\left(\mathbf{R}\boldsymbol{x},\boldsymbol{y}\right)=\frac{\pi}{2}$, in computer vision and robotics that can be expressed linearly are deeply discussed in this paper.
Functional Morphology and Ecological Role of Therizinosaurs: A Focused Review
Authors: Hu Tyler
Published: February 2025

Therizinosaurs, a unique clade of theropod dinosaurs, are characterized by their distinct morphological features and enigmatic ecological role. This review provides a comprehensive analysis of the functional morphology and ecological significance of these remarkable dinosaurs. Therizinosaurs are distinguished by their elongated, often curved claws, robust postcranial skeletons, and herbivorous diet, which starkly contrasts with their carnivorous theropod relatives. We explore the evolutionary implications of their morphology, focusing on adaptations such as their specialized feeding apparatus and limb structure. These features suggest a complex interplay between their herbivorous lifestyle and ecological niche. The review synthesizes recent findings from fossil evidence, including detailed studies of cranial and postcranial anatomy, to elucidate the functional mechanisms behind their unique adaptations. Additionally, we discuss the broader ecological role of therizinosaurs within their Mesozoic ecosystems, highlighting their interactions with contemporaneous flora and fauna. By integrating paleontological data with comparative anatomy and ecological modeling, this review aims to shed light on the evolutionary trajectory of therizinosaurs and their impact on our understanding of theropod diversity and adaptation. This focused review contributes to a more nuanced appreciation of therizinosaurs' place in dinosaur evolution and their adaptive strategies in prehistoric environments.