bluuebunny/crossref_metadata_2025 huggingface dataset:
PLAG1 Promotes High Glucose-Induced Angiogenesis and Migration of Retinal Endothelial Cells by Regulating the Wnt/β-Catenin Signalling Pathway
Authors: Gu Q. , Wei Haifeng
Published: July 2023

Proliferation and migration of retinal endothelial cells (RECs) contribute to the development of diabetic retinopathy. PLAG1 (pleomorphic adenoma gene 1) functions as a zinc-finger transcription factor to participate in the development of lipoblastomas or pleomorphic adenomas of the salivary glands through regulation of cell proliferation and migration. The role of PLAG1 in diabetic retinopathy was investigated in this study. Firstly, RECs were induced under high glucose conditions, which caused reduction in viability and induction of apoptosis in the RECs. Indeed, PLAG1 was elevated in high glucose-treated RECs. Functional assays showed that silence of PLAG1 increased viability and suppressed apoptosis in high glucose-induced RECs, accompanied with up-regulation of Bcl-2 and down-regulation of Bax and cleaved caspase-3. Moreover, migration of RECs was promoted by high glucose conditions, while repressed by knockdown of PLAG1. High glucose also triggered angiogenesis of RECs through up-regulation of vascular endothelial growth factor (VEGF). However, interference of PLAG1 reduced VEGF expression to retard the angiogenesis. Silence of PLAG1 also attenuated high glucose-induced up-regulation of Wnt3a, β-catenin and c-Myc in RECs. Moreover, silence of PLAG1 ameliorated histopathological changes in the retina of STZ-induced diabetic rats through down-regulation of β-catenin. In conclusion, knockdown of PLAG1 suppressed high glucose-induced angiogenesis and migration of RECs, and attenuated diabetic retinopathy by inactivation of Wnt/β-catenin signalling.
Multisystem inflammatory syndrome in a child associated with COVID-19: a clinical case report
Authors: Kosmynina N. S. , Dats-Opoka M. I.
Published: July 2023

Multisystem inflammatory syndrome in children (MIS-C) who contracted COVID-19 remains an urgent problem. Mortality due to this disease among children ranges from 0.8 % to 2.0 %. According to reports found in the literature, MIS-C can develop both in children who have experienced COVID-19 without clinical manifestations, and in those who have had a severe course of the disease.
To date, there are no well-defined factors that allow predicting the risk of developing MIS-C in children after experiencing COVID-19, and the spectrum of clinical manifestations can be quite diverse.
Aim: on the example of a specific case, to examine and analyze the features of the course and the range of diagnostic measures in children with MIS-C using an analytical method and a systemic approach.
Materials and methods. The material was a clinical case of MIS-C, methods of instrumental diagnosis and objective analysis. The diagnosis of MIS-C was based on the WHO 2021 criteria for the diagnosis of MIS-C associated with COVID-19.
Results. The clinical case of MIS-C associated with COVID-19 in a child with congenital thymus pathology that resulted in rapid, aggressive, and worsening multiple organ failure was studied. The manifestations were dominated by liver failure, respiratory failure, circulatory failure, and neurological deficiency, that led to the child’s death.
Conclusions. Multisystem inflammatory syndrome in children associated with SARS-CoV-2 infection can lead to serious and life-threatening complications in previously clinically healthy children.
Physicians need to be more alert to children of different age groups with manifestations of respiratory infections as potential COVID-19 and to test for its presence, which will subsequently allow timely identification of children with MIS-C associated with SARS-CoV-2.
Considering the probable role of the thymus in the pathogenesis and course of MIS-C associated with SARS-CoV-2, we recommend an ultrasound examination of the thymus for all children under 3 years of age with confirmed COVID-19 and followed by examination of T-cellular response if changes are detected.
Ciągłość i zwartość struktury przyrodniczej a funkcjonowanie krajobrazu. Studium przypadku integracji planistycznej i projektowej w gminie Września
Authors: Szczepańska Magdalena , Knasińska Weronika Maria
Published: July 2023

W literaturze przedmiotu pojawia się szereg pojęć, które odnoszą się do szeroko pojętych struktur przyrodniczych. Zachodzi pytanie, czy transponowanie tych pojęć do dokumentów planistyczno-strategicznych sprzyja integracji i spójności planowania przestrzennego oraz ciągłości krajobrazowej i zwartości struktury przyrodniczej na danym terenie. Celem opracowania jest sformułowanie koncepcji zintegrowania struktury ekologicznej krajobrazu gminy Września. Aby zrealizować przyjęty cel, przeprowadzono inwentaryzację struktur przyrodniczych oraz elementów infrastruktury technicznej. Ponadto dokonano weryfikacji lokalnych i ponadlokalnych zapisów planistycznych oraz strategicznych w kontekście struktur przyrodniczych dla gminy Września. W tym celu określono i obliczono wskaźnik integracji pionowej oraz poziomej zapisów planistyczno- -strategicznych. Badania wykazały przeciętny poziom integracji dokumentów planistycznych gminy. Najwyższy wskaźnik zintegrowania dokumentów odnotowano na szczeblu lokalnym. W  układzie przyrodniczym gminy odnotowano zróżnicowane formy zieleni oraz luki i bariery w ciągłości jego funkcjonowania.
Pozawzrokowe postrzeganie krajobrazu przez zróżnicowane grupy użytkowników na przykładzie Bydgoszczy
Authors: Juchacz Olga , Czerwiński Patryk , Wilkaniec Agnieszka
Published: July 2023

Percepcja krajobrazu związana jest przede wszystkim ze zmysłem wzroku. Percepcję wzrokową uzupełniają wrażenia odbierane przez inne zmysły: słuchu, węchu i dotyku. Celem badań była identyfikacja krajobrazów miasta Bydgoszczy postrzeganych pozytywnie oraz negatywnie za pomocą zmysłów innych niż wzrok. W badaniu zastosowano metodę kwestionariuszową. Respondentami byli mieszkańcy miasta oraz osoby przyjezdne wśród nich grupa uczniów technikum z klasy architektury krajobrazu oraz grupa osób niesłyszących. Ustalono, że dla większości respondentów decydującą rolę w  postrzeganiu krajobrazu, obok wzroku, odgrywa zmysł węchu i  słuch. Najatrakcyjniejsze okazały się dla nich tereny związane z zielenią i wodą oraz wyłączone z ruchu w centrum miasta. Za nieatrakcyjne uznano obszary obciążone ruchem samochodowym, zaniedbane i zatłoczone.
The Sophists’ Detractors and Plato’s Representation of Socrates
Authors: Long Alex
Published: July 2023

In several dialogues Socrates criticizes negative comments made against a sophist or the sophists. I show that Socrates’ target really is the sophists’ detractor, not the sophists themselves. From these passages I draw two broader conclusions. First, Plato’s defence of Socrates’ memory sometimes relies on creating a parallel between sophists and Socrates, rather than distinguishing between them and him. Secondly, Socratic philosophical practice has a widely neglected feature: examining and correcting the criticism made by his interlocutors against others.
TNF-α and IL-8 levels are positively correlated with hypobaric hypoxic pulmonary hypertension and pulmonary vascular remodeling in rats
Authors: Shi Haixia , Zhao Yongfeng , Li Su , Wu Haitao , Ma Dehua , Wan Chenchen
Published: July 2023

The expression status of proinflammatory cytokines in high-altitude pulmonary arterial hypertension (PAH) has been well studied. However, the changes in interleukin (IL)-8 and tumor necrosis factor α (TNF-α) during the reversible changes in pulmonary vascular remodeling (PVR) in PAH after detaching from a hypobaric hypoxic environment have not been elucidated. This investigation elucidated a high-altitude PAH rat model. Then, PAH rats in the high-altitude group were maintained in the high-altitude area, and rats in the low-altitude group returned to the low-altitude area. After 0, 10, 20, and 30 days of PAH modeling, right ventricular systolic pressure (RVSP) and the mean pulmonary arterial pressure (mPAP) were assessed. Right ventricular (RV) hypertrophy was reflected by the ratio of RV/[left ventricle + interventricular septum (S)]. Pathological changes in PVR were accessed by hematoxylin-eosin staining, and medial wall thickness (WT%) and medial wall area (WA%) were measured. TNF-α and IL-8 levels in pulmonary artery tissues and blood were measured with Western blot assay and enzyme-linked immunosorbent assay, respectively. Our results showed that PAH rats exhibited a substantial increase in RVSP and mPAP, RV hypertrophy, PVR, and enhanced generation of TNF-α and IL-8. Then, we found that these pathological changes were gradually aggravated and TNF-α and IL-8 levels were increased in rats in the high-altitude group after 10, 20, and 30 days of PAH modeling. In contrast, the mPAP was decreased and PVR was alleviated in rats in the low-altitude group, accompanying with reduced TNF-α and IL-8 production. In conclusion, our study demonstrated that the generation of TNF-α and IL-8 was also reversible during the reversible changes in PVR after detaching from a hypobaric hypoxic environment. Thus, proinflammatory cytokine TNF-α and IL-8 levels are positively correlated with PVR severity.
Social Capital and Innovative Performance in Networks: The Journey of Romanian SaaS Entrepreneurs
Authors: Clipa Anca Maria , Chițac Iuliana M. , Clipa Cătălin Ioan , Florea Nelu
Published: July 2023

Entrepreneurship is increasingly acknowledged as a critical economic and growth driver. As a result, practitioners’ and scholars’ inquiry into the link between the entrepreneurial social network and its pursuit of innovation have gained momentum in developed economies. However, it remains scarce in the context of emergent economies. Drawing upon social network theory, this qualitative study explores this knowledge gap by examining how Romanian software as a service (SaaS) entrepreneurs enable innovative performance by using social capital in national and international entrepreneurial networks. This qualitative interpretative study relies on the experiences and practices shared by 24 Romanian SaaS entrepreneurs interviewed to expand our understanding of how these entrepreneurs use social capital-driven networks to achieve innovative performance in international markets. Feeling unsupported by a weak institutional entrepreneurial context, Romanian SaaS entrepreneurs build their international entrepreneurial journeys and achieve innovative performance extensively by relying on social capital-driven networks. This paper contributes to the emergent economies stream on entrepreneurship literature and regional entrepreneurship policies. These findings show that motivated to overcome the challenges of a weak institutional context and pursue their entrepreneurial path, these Romanian SaaS entrepreneurs’ international presence and innovative performance are relational manifestations of bonding and bridging social capital-based networks.
Funktionen fachlicher Kommunikation
Authors: Roelcke Thorsten
Published: July 2023

Fachliche Kommunikation erfüllt zahlreiche Funktionen. Um diese systematisch zu erfassen, sind sie an einem allgemeinen Modell fachlicher Kommunikation festzumachen, indem jedem seiner Elemente eine eigene kommunikative Funktion zugewiesen wird. Nach dieser Methode, die (ohne besondere Berücksichtigung fachlicher Kommunikation) bei Karl Bühler zum Ansatz von drei und bei Roman Jakobson zum Ansatz von sechs kommunikativen Funktionen führt, können schließlich neun bzw. elf fachkommunikative Funktionen unterschieden werden, die letztlich auch auf den Bereich der allgemeinen Kommunikation zu übertragen sind: Eine symptomatische, eine appellative, eine referentielle, eine epistemische, eine poetische, eine phatische, eine semiotische, eine diskursive und eine situative bzw. soziale oder kulturelle Funktion. Diese Funktionen werden in diesem Beitrag vorgestellt und erläutert sowie am Beispiel einer Fortbildung im IT-Bereich veranschaulicht.
‚Linksversetzungen‘ im Mittelhochdeutschen als Beispiel narrativer Syntax
Authors: Zeman Sonja
Published: July 2023

Linksversetzungen (e.g. Meine Tante, die hat uns oft aus dem Parzival vorgelesen.; im Folgenden LV) gelten übereinzelsprachlich als ein typisches Charakteristikum gesprochener Sprache bzw. als Anzeichen einer ‚oralen‘ Syntax. Diese Bewertung korreliert mit dem Befund, dass LV im Mittel- und Frühneuhochdeutschen tendenziell frequenter in denjenigen Textsorten vorkommen, die der konzeptionellen Mündlichkeit nahestehen (Lötscher 1994: 48). Anders als man aufgrund des ‚oralen‘ Charakters der LV erwarten könnte, sind diese im Nibelungenlied jedoch häufiger in den narrativen als in den Dialog-Passagen belegt (Zeman 2022). Auf der Suche nach einer Erklärung für diesen Befund vergleicht der Beitrag die Textfunktionen der LV im Nibelungenlied und im Tristan und zeigt, dass LV in beiden Versepen narrative Funktionen der (Re-)Aktualisierung einzelner Diskursreferenten leisten und damit nicht nur als Charakteristika der Mündlichkeit anzusehen sind, sondern auch als Charakteristika des mündlichen Erzählens. Dieses Ergebnis führt zu einem modifizierten Blick auf die Textsortenabhängigkeit der LV und ihrer Entwicklungslinie in der Diachronie des Deutschen.
Koordinationsellipsen in Patientenbriefen des 19. und frühen 20. Jahrhunderts
Authors: Gunkler-Frank Katharina
Published: July 2023

Dieser Beitrag untersucht, ob sich die theoretische Verortung von Koordinationsellipsen und ihren aggregativen Formen im Nähe-Distanz-Kontinuum auch im Sprachgebrauch historischer Schreibender widerspiegelt. Dazu wird anhand eines Korpus von 202 Patientenbriefen aus dem 19. und frühen 20. Jahrhundert intra- und interindividuelle Variation untersucht. Dabei zeigt sich, dass entsprechend ihrer theoretischen Einordnung Koordinationsellipsen häufiger unter distanzsprachlichen und aggregative Koordinationsellipsen häufiger unter nähesprachlichen Kommunikationsbedingungen auftreten.
Erkläransätze zu Unterschieden in der Verbreitung der tun-Peri­phrase in extraterri­to­ri­alen Varietäten des Deutschen
Authors: Saller Anna
Published: July 2023

Die tun-Periphrase (tP) ist im Standarddeutschen stigmatisiert, kommt aber in Dialekten wie in extraterritorialen Varietäten des Deutschen teilweise sehr häufig vor. Eine vergleichende Untersuchung deutscher Varietäten in Texas, Australien, Siebenbürgen und Namibia ergab, dass die tP in diesen Gebieten unterschiedlich häufig auftrat. Dieser Aufsatz diskutiert die möglichen Gründe für diese Frequenzunterschiede. Neben Ursprungsdialekten und Sprachkontakt werden auch außersprachliche Einflüsse und eine natürliche Entwicklung (im Givón’schen Sinne einer pragmatischen Verwendung) in den Blick genommen, für die Salienz der sprachlichen Form und die kommunikativen Rahmenbedingungen einer Sprache zentral sind.
Futurkonstruktionen im Wandel: werden + Infinitiv und Konkurrenzmuster aus konstruktionsgrammatischer Perspektive
Authors: Hartmann Stefan , Schnee Lena
Published: July 2023

Die Frage nach der Entstehung und nach dem Status der Konstruktion werden + Infinitiv ist trotz umfangreicher Forschung zu diesem Themengebiet nach wie vor umstritten. Es existieren unterschiedlichste Theorien zum Verhältnis der Konstruktion zu möglichen Vorgänger- und/oder Konkurrenzkonstruktionen wie etwa werden + Partizip Präsens oder Modalverbkonstruktionen. In diesem Beitrag fassen wir erste Ergebnisse eines Projekts zusammen, das sich der Frage nach dem Verhältnis konkurrierender Futurkonstruktionen anhand korpusbasierter Analysen widmet. Dabei nehmen wir in der hier vorgestellten Pilotstudie zunächst die Konstruktionen werden + Infinitiv und werden + Partizip Präsens in den Blick. Wir können dabei auf in den letzten Jahren verfügbar gewordene Korpusressourcen zurückgreifen, insbesondere das seit 2016 verfügbare Referenzkorpus Mittelhochdeutsch (ReM). Wir argumentieren, dass eine systematische Analyse der in den Konstruktionen auftretenden Verben hinsichtlich ihrer Aktionsart wichtige Rückschlüsse auf die semantische Entwicklung der einzelnen Konstruktionen zulässt, und diskutieren das Potential einer konstruktionsgrammatischen Herangehensweise an die Untersuchung konkurrierender Futurkonstruktionen.
Die rheinisch-hochdeutsche Pronominalgrenze – vergessene Formen und Systeme
Authors: Klein Andreas
Published: July 2023

Die rheinischen Dialekte unterscheiden sich hinsichtlich der Pronominalmorphologie und -syntax merklich vom (übrigen) Hochdeutschen. Dies zeigt sich besonders eindrücklich im moselfränkisch-rheinfränkischen Übergangsgebiet, das in den Erhebungsbereich des Mittelrheinischen Sprachatlasses (MRhSA) fällt. Im Rahmen der Untersuchung wird das ursprüngliche Atlas-Material aus den achtziger Jahren neu ausgewertet, um eine aktuelle Nacherhebung mit den gleichen Gewährspersonen ergänzt und mit den Wenker-Daten verglichen. Dabei treten nicht nur eklatante Formunterschiede zutage, sondern auch komplexe Systeme wie die verschiedenen Reihen des rheinischen Possessivums, die sich bis in die mittelhochdeutsche Zeit zurückverfolgen lassen und erst in den letzten Jahrzehnten abgebaut werden.
Regularization of backward parabolic equations in Banach spaces by generalized Sobolev equations
Authors: Duc Nguyen Van , Hào Dinh Nho , Shishlenin Maxim
Published: July 2023

Let X be a Banach space with norm

∥
⋅
∥

{\|\cdot\|}

. Let

A
:

D
⁢

(
A
)

⊂
X
→
X

{A:D(A)\subset X\rightarrow X}

be an (possibly unbounded) operator that generates a
uniformly bounded holomorphic semigroup. Suppose that

ε
>
0

{\varepsilon>0}

and

T
>
0

{T>0}

are two given constants.
The backward parabolic equation of finding a function

u
:

[
0
,
T
]

→
X

{u:[0,T]\rightarrow X}

satisfying

u
t

+

A
⁢
u

=
0

,

0
<
t
<
T

,

∥

u
⁢

(
T
)

-
φ

∥

⩽
ε

,

u_{t}+Au=0,\quad 0<t<T,\;\|u(T)-\varphi\|\leqslant\varepsilon,

for φ in X, is regularized by the generalized Sobolev equation

u

α
⁢
t

+

A
α

⁢

u
α

=
0

,

0
<
t
<
T

,

u
α

⁢

(
T
)

=
φ

,

u_{\alpha t}+A_{\alpha}u_{\alpha}=0,\quad 0<t<T,\;u_{\alpha}(T)=\varphi,

where

0
<
α
<
1

{0<\alpha<1}

and

A
α

=

A
⁢

(

I
+

α
⁢

A
b

)

-
1

{A_{\alpha}=A(I+\alpha A^{b})^{-1}}

with

b
⩾
1

{b\geqslant 1}

. Error estimates of the method with respect to the noise level are proved.
Covid-19 Pandemic and Digital Public Awareness Platforms: Strategies, Solutions, and Tools of Communication and e-Government Data Management
Authors: Kassen Maxat
Published: July 2023

The global outbreak of the Covid-19 pandemic has forced governments around the world to launch various digital information campaigns in an attempt to boost public awareness about the virus and increase public information on effective measures to prevent its diffusion in local communities. Different public relations and data preservation, data retention, and data distribution strategies have been applied by healthcare policymakers to initiate, implement, and promote a wide range of public information campaigns, unique open data-driven platforms, and related digital solutions and tools to achieve the goal. Likewise, they were driven by different motivations and priorities as well as demands and political signals that they received from both top government leadership and civil society. In this regard, it is interesting to analyze how these different public relations and data management strategies were manifested in real administrative and technological practices, what priorities policymakers put in promoting such digital platforms, what communication and data management tools they used, and how effective they were in raising public awareness about the pandemic via such digital information platforms and related data-driven projects, startups, and initiatives.
Influence of isopropanol on the rheological behavior of wormlike micelles
Authors: Abdel-Rahem Rami A. , Clinckspoor Karl Jan , Hoffmann Heinz
Published: July 2023

The influence of replacing water with isopropanol (IP) on the rheological properties of aqueous solutions containing wormlike micelles (WLMs) prepared by mixing cetyltrimethylammonium bromide (CTAB) and sodium salicylate (NaSal) at 25 °C was investigated. Viscosity of CTAB aqueous solutions exhibits two maxima and one minimum with increasing amounts of NaSal, consisting of entangled WLMs. When water is replaced by increasing amount of IP, the viscosity maxima and the minimum changes drastically. The elastic plateau modulus G° of these solutions remains almost the same with increasing IP contents (up to ∼5 wt%), whereas their relaxation time changes drastically. Critical micelle concentration (CMC) of CTAB has increased with further IP addition, indicating an increase in the micellar hydrophilicity. For WLMs at minimum viscosity, increasing addition of IP (>5.0 %) to WLMs at maximum and minimum viscosities, leads to a drastic decrease in the elastic modulus G°, indicating the formation of smaller micellar aggregates. The influence of IP as a co-solvent on the WLMs rheological properties is also compared to that of glycerol and 1,3 butanediol (1,3 BD) for the same NaSal/CTAB viscoelastic system.
Branched‐chain amino acid synthesis is coupled to TOR activation early in the cell cycle in yeast
Authors: Blank Heidi M , Reuse Carsten , Schmidt‐Hohagen Kerstin , Hammer Staci E , Hiller Karsten , Polymenis Michael
Published: July 2023

How cells coordinate their metabolism with division determines the rate of cell proliferation. Dynamic patterns of metabolite synthesis during the cell cycle are unexplored. We report the first isotope tracing analysis in synchronous, growing budding yeast cells. Synthesis of leucine, a branched‐chain amino acid (BCAA), increases through the G1 phase of the cell cycle, peaking later during DNA replication. Cells lacking Bat1, a mitochondrial aminotransferase that synthesizes BCAAs, grow slower, are smaller, and are delayed in the G1 phase, phenocopying cells in which the growth‐promoting kinase complex TORC1 is moderately inhibited. Loss of Bat1 lowers the levels of BCAAs and reduces TORC1 activity. Exogenous provision of valine and, to a lesser extent, leucine to cells lacking Bat1 promotes cell division. Valine addition also increases TORC1 activity. In wild‐type cells, TORC1 activity is dynamic in the cell cycle, starting low in early G1 but increasing later in the cell cycle. These results suggest a link between BCAA synthesis from glucose to TORC1 activation in the G1 phase of the cell cycle.
Determinant of Vocational High School’s Open Unemployment
Authors: Mahroza Ayu Dian
Published: July 2023

This study aimed to determine the effect of gender, school origin status, national exam scores, work experience, residence and English language skills on unemployment in Sleman Regency. The data used in this study were primary data obtained through questionnaire distributed to vocational high school alumni who graduated in 2018 and 2019. The sampling technique used was non-probability sampling, while for the analysis, it used logit regression analysis tools. The results showed that the variables of gender and school origin status had positive and significant effects on unemployment opportunities for vocational high school graduates. The variables of national exam scores, work experience and English language skills had negative and significant effects on the unemployment opportunities of vocational high school graduates. Meanwhile, the length of work experience and distance from residence to city did not have significant effects on the probability of being unemployed for vocational high school graduates.

Penelitian ini bertujuan untuk mengetahui pengaruh jenis kelamin, status asal sekolah, nilai ujian nasional, pengalaman kerja, tempat tinggal dan kemampuan bahasa Inggris terhadap pengangguran di Kabupaten Sleman. Data yang digunakan dalam penelitian ini adalah data primer yang diperoleh melalui penyebaran kuesioner kepada alumni SMK lulusan tahun 2018 dan 2019. Teknik pengambilan sampel yang digunakan adalah non-probability sampling, sedangkan untuk analisisnya menggunakan alat analisis regresi logit. Hasil penelitian menunjukkan bahwa variabel jenis kelamin dan status asal sekolah berpengaruh positif dan signifikan terhadap kesempatan kerja lulusan SMK. Variabel nilai ujian nasional, pengalaman kerja dan kemampuan bahasa Inggris berpengaruh negatif dan signifikan terhadap peluang pengangguran lulusan SMK. Sementara itu, lama pengalaman kerja dan jarak tempat tinggal ke kota tidak berpengaruh signifikan terhadap peluang menganggur lulusan SMK.
The Effect of Economic Growth, Population and Unemployment on HDI
Authors: Wahyuningrum Febrianti , Soesilowati Etty
Published: July 2023

East Java Province is a province in Indonesia, which has the potential to develop. Provincial HDI has increased every year, but the HDI of East Java Province is quite low compared to the HDI of other provinces in Java. The rate of economic growth that occurred in East Java Province decreased. The existence of the unemployment rate causes the prosperity of the community to be not optimal, while the purpose of human development is to create community welfare. The data used in this research is using secondary data. This study uses the ordinary least square method with multiple regression analysis. This study uses a combination of time series data from 2014-2018 and a cross section of 38 districts or cities in East Java Province. The variables used are Economic Growth Rate, Population and Open Unemployment Rate. Based on the research results, it can be concluded that the population has a significant effect on the human development index (HDI) and the rate of economic growth and the open unemployment rate does not significantly affect the Human Development Index (HDI).

Provinsi Jawa Timur merupakan Provinsi di Indonesia tepatnya di Pulau Jawa yang mempunyai potensi untuk berkembang. IPM Provinsi mengalami peningkatan setiap tahunnya, namun IPM Provinsi Jawa Timur cukup rendah dibandingkan dengan IPM Provinsi lain yang ada di Pulau Jawa. Laju pertumbuhan ekonomi yang terjadi pada Provinsi Jawa Timur terjadi penurunan. Adanya Tingkat pengangguran menyebabkan kemakmuran masyarakat tidak maksimal sedangkan tujuan adanya pembangunan manusia adalah untuk menciptakan kesejahteran masyarakat. Data yang digunakan dalam penelitian ini adalah menggunakan data sekunder. Penelitian ini menggunakan metode ordinary least square dengan analisis regresi berganda. Penelitian ini menggunakan gabungan antar data time series yaitu dari tahun 2014-2018 dan cross section 38 kabupaten atau kota di Provinsi Jawa Timur. Variabel yang digunakan adalah Laju Pertumbuhan Ekonomi, Jumlah Penduduk dan Tingkat Pengangguran Terbuka. Berdasarkan hasi penelitian, dapat diambil kesimpulan bahwa Jumlah Penduduk memiliki pengaruh signifikan terhadap indeks pembangunan manusia (IPM) dan laju pertumbuhan ekonomi dan tingkat pengangguran terbuka tidak berpengaruh secara signifikan terhadap Indeks Pembangunan Manusia (IPM).
Cooperación cultural y educativa española en Egipto. (Origen y evolución)
Authors: Fuentelsaz Franganillo Jorge
Published: July 2023

Las relaciones culturales entre España y Egipto se han caracterizado por una personalidad propia desde su comienzo, quizá antes más que ahora, cuando Egipto se erigía en el verdadero adalid del Mundo Árabe, o lo intentaba con bastante éxito. Las relaciones culturales nacieron antes que cualquier otro tipo de relación y se desarrollaron a base de numerosos acuerdos. Prueba de ello son los al menos 12 documentos relativos a este campo que desde 1952 hasta hoy, han ido marcando la política cultural bilateral, frente a los acuerdos de carácter político, económico o turístico, que con el tiempo han ganado terreno en detrimento de lo cultural
Poder y Estado rentista en el mundo árabe
Authors: Izquierdo Brichs Ferrán
Published: July 2023

Artículo
La cuestión nuclear en las relaciones entre la Unión Europea y la República Islámica de Irán (2003-2006): de la “Política Negociadora” al Consejo de Seguridad de Naciones Unidas
Authors: Arce Sánchez Natalia
Published: July 2023

Este trabajo intenta abordar las principales razones que explican la progresión de la postura de la UE respecto a Irán, desde la ‘política negociadora’ al apoyo al envío de la cuestión nuclear al Consejo de Seguridad de la ONU. Para ello, el primer apartado ofrecerá una breve introducción sobre los antecedentes del diálogo entre el organismo europeo y la República Islámica. Los siguientes apartados se centrarán en analizar en detalle dos de los aspectos fundamentales que tendrán un impacto en las relaciones euro-iraníes: el estancamiento de las negociaciones UE-Irán y el acercamiento transatlántico, que incrementará la presión ejercida por parte de los Estados Unidos, hecho que coincide con una mayor receptividad por parte de los países europeos a las demandas estadounidenses.AbstractThis paper focuses in analyze the main reasons that explain the progression of the position of the UE toward Iran, from ‘political negotiator’ to supporting the envoy of the nuclear dossier to the UN’s Security Council. For it, the first part will offer a brief introduction of the dialogue’s antecedents between the European organism and the Islamic Republic. The following part will be centered in analyzing in detail two of the fundamental aspects that they will have an impact in the euro-Iranian relations: the stagnation of the UE-Iran negotiations and the transatlantic approach. This fact will increase the pressure exerted on the part of the United States, at the same time that fits with a greater receptivity on the part of the European countries to the American demands.
Las elecciones legislativas marroquíes de 2007
Authors: López García Bernabé
Published: July 2023

Artículo
Bahrain: ¿un reino en busca de democracia?
Authors: Saldaña Martín Marta
Published: July 2023

Este artículo sostiene que las reformas políticas llevadas a cabo en Bahrain desde 1999, forman parte de una estrategia de relegitimación de la Monarquía ante las demandas de la sociedad civil, y ante la presión democratizadora de la comunidad internacional. Para explicar cómo funcionan los mecanismos adoptados desde la ratificación de la Constitución de 2002, se presenta un análisis de la evolución de las instituciones políticas desde la creación del Estado hasta la actualidad. Así mismo, se incluye una aproximación sociológica a los actores políticos y una evaluación de los límites que impiden llevar más allá la liberalización política del país.AbstractThis paper states that the political reforms implemented in Bahrain since 1999 are part of a re- legitimation strategy of the Monarchy which responds to the demands of civil society and to the international community democratizing pressure. An analysis of the evolution of political institutions since the creation of the state until today is presented in order to explain how the mechanisms adopted after the ratification of 2002 Constitution work. There are also included a sociological approach to political actors and an evaluation of the limits that hold back the political liberalization of the country.
Research on the Influencing Mechanism of Service Quality on Brand Equity toward Real Estate Company
Authors: Sun Xiu , Yao Jian
Published: July 2023

China's social economy has seen a rapid and healthy development, resulting in a steady rise in per capita disposable economic income, thus improving the living standards of the people and continually altering their social needs. People are gradually no longer just meeting their most basic needs, but also want to enrich their lives through tourism. S Water World is a major characteristic tourism product under X Group, the number of tourists received by the attraction reaches 4.08 million every year, there are tourists throughout the year, and the number of tourists is increasing year by year. X Group is a collection of real estate, construction, transportation and cultural tourism and other industries in one, X Group, as a cultural tourism real estate brand, integrates modern agriculture, theme parks, research and education, catering and accommodation and health town. In order to help develop the tourism industry, this article formulates relevant industry training regulations to promote the rapid and stable development of tourism in the post-epidemic era. A total of 500 valid survey questionnaires were sent out in this survey, a total of 470 valid survey answers were returned, and finally screened, a total of 440 valid survey answers were selected, and the overall questionnaire effectiveness exceeded 90%. Through research, the authors found that the involvement of tourists in S Water World has a mediating role in the relationship between their perceived service quality and perceived brand equity, and the research conclusion of this paper is that while maintaining service quality, service value and customer brand trust, appropriate use of marketing means to promote water parks, expand the understanding of the society, so that the public can have more opportunities to receive information about the park, thereby generating interest in visiting Water World, that is, strengthening tourists' involvement.
Spatiotemporal dynamics in a toxin-producing predator–prey model with threshold harvesting
Authors: Ye Luhong , Zhao Hongyong , Wu Daiyong
Published: July 2023

In this paper, we propose a toxin-producing predator–prey model with threshold harvesting and study spatiotemporal dynamics of the model under the homogeneous Neumann boundary conditions. At first, the persistence property of solutions to the system is investigated. Then the explicit requirements for the existence of nonconstant steady state solutions are derived by studying the relevant characteristic equation. These steady states occur from related constant steady states via steady state bifurcation. Throughout the analysis of the amplitude equations of Turing pattern by the multiple scale method, pattern formation can be found. Finally, we display  umericalsimulations to verify the theoretical outcomes.
Ablation as First-line Therapy for Atrial Fibrillation
Authors: Andrade Jason G
Published: July 2023

AF is a chronic and progressive heart rhythm disorder characterised by exacerbations and remissions. Contemporary guidelines recommend antiarrhythmic drugs (AADs) as the initial therapy for the maintenance of sinus rhythm. However, these medications have modest efficacy and are associated with significant adverse effects. Several recent trials have evaluated catheter ablation as an initial therapy for AF, demonstrating that cryoballoon catheter ablation significantly improves arrhythmia outcomes (e.g. atrial tachyarrhythmia recurrence and arrhythmia burden), produces clinically meaningful improvements in patient-reported outcomes (e.g. symptoms and quality of life), and significantly decreases healthcare resource usage (e.g. hospitalisation), without increasing the risk of serious adverse events. Moreover, in contrast to antiarrhythmic drugs, catheter ablation appears to be disease-modifying, significantly reducing the progression of disease. These findings are relevant to patients, providers, and healthcare systems, helping inform the initial choice of rhythm-control therapy in patients with treatment-naïve AF.
Kronik böbrek hastalarında solunum kas kuvveti, egzersiz kapasitesi ve fizyolojik harcama indeksinin değerlendirilmesi
Authors: FIRAT Merve , VARDAR YAGLI Naciye , YILDIRIM Tolga , SAĞLAM Melda , ÇALIK KÜTÜKÇÜ Ebru , İNCE Deniz
Published: July 2023

Amaç: Bu çalışmanın amacı evre 3 kronik böbrek hastalığı olan bireylerde solunum kas kuvveti, egzersiz kapasitesi ve fizyolojik harcama indeksini değerlendirmek idi.

Yöntem: Yirmi dört evre 3 kronik böbrek hastası (46,21±9,48 yıl, 13 kadın (%54,2), 11 erkek (%45,8)) retrospektif olarak incelendi. Solunum kas kuvveti (maksimal inspiratuar basınç ve ekspiratuar basınç) ağız basıncı ölçüm cihazı, egzersiz kapasitesi 6 dakika yürüme testi ve enerji harcaması fizyolojik harcama indeksi ile değerlendirildi.

Bulgular: Kronik böbrek hastalarının %62,5’inde inspiratuar kas zayıflığı (81,29±17,74 cmH2O), %79,17’sinde egzersiz kapasitesinde azalma (501,92±58,50 metre) ve %75’inde artmış fizyolojik harcama indeksi (0,47±0,13 atım/metre) vardı.

Sonuç: Hastalığın erken evrelerinde olmalarına rağmen evre 3 kronik böbrek hastalarının solunum kas kuvveti ve egzersiz kapasitesinin azaldığı, enerji harcamasının ise arttığı görülmüştür. Bu hastalarda solunum kas ve aerobik egzersiz eğitimi ile solunum kas kuvveti, egzersiz kapasitesi ve enerji harcamasında gelişme sağlanabilir.
Safeguarding Communities: Exploring the Tradition of Tolak Bala in Nagari Bungus
Authors: Lisman Resta , Darmaiza Darmaiza , Wahyuni Dwi
Published: July 2023

This study aims to examine the tradition of tolak bala in Nagari Bungus, including the changes that have occurred, the factors influencing the persistence of the tradition, and the meanings understood by the community regarding the tradition. A qualitative approach was employed, and data were collected through interviews and participatory observation. The findings reveal changes in the tradition of tolak bala in Nagari Bungus, encompassing changes in the surrounding environment and social activities of the community. The tradition of tolak bala has had a positive impact on the community, such as improving their relationship with Allah Swt, enhancing economic conditions, and abandoning negative behaviors. Factors influencing the persistence of the tradition of tolak bala include the community's beliefs and knowledge, religious activities, and the roles of traditional and religious leaders. The community understands the tradition of tolak bala as a means of protection from dangers and as an effort to seek help from Allah Swt to avert calamities. This research provides deeper insights into the tradition of tolak bala in Nagari Bungus and has implications for social and cultural changes in the community. Recommendations are given to the Bungus community and local authorities to preserve and maintain the tradition of tolak bala as a valuable cultural heritage and to conduct further research on this tradition in other regions.
When Tradition Meets Modernity: The Adaptation of Bajau Community in Malaysia Amidst Sociocultural Transformation
Authors: Zainuddin Mohd. Fadzil
Published: July 2023

This research aims to analyze how the Bajau community in Kulambai Village, Kota Belud, Sabah, Malaysia, adapts their traditional practices in response to modernization. Modernization has brought significant changes in various aspects of life, including local culture and traditions. The Bajau community, having lived with local wisdom and distinctive traditions, now faces significant pressure to integrate with the ever-evolving modern world. This study utilizes a qualitative approach, collecting data through in-depth interviews with members of the Bajau community in Kulambai Village. Participatory observation is also conducted to understand how traditional practices interact with modern elements in daily life. The collected data are then analyzed to identify patterns and key findings related to traditional adaptation in the face of modernization. The research results indicate that the Bajau community in Kulambai Village is experiencing changes in their traditional practices in response to modernization. They face a dilemma between preserving their cultural identity and adapting to the social and economic changes brought by modernization. Factors such as education, urbanization, and media influence also affect this adaptation process. Resource limitations and challenges in maintaining local wisdom pose obstacles for the Bajau community. Nevertheless, efforts to preserve traditions and cultural values are continually made by some Bajau community groups. This research provides a deeper understanding of how the Bajau community in Kulambai Village adapts their traditional practices in the face of modernization. The results can make a significant contribution to efforts to preserve local culture and traditions amidst rapid social change. Recommendations for further research include expanding the scope of the study to Bajau communities in other regions and deepening the analysis of modernization's impact on their cultural aspects.
Transforming Religious and Monarchial Power
Authors: Hubbert Jake
Published: July 2023

The political landscape of the emergent medieval Georgian nation among the predominant Islamic emirates is a relatively new field for western scholars. The Medieval Georgian polity, led by King Davit IV (Aghmshenebeli), rose to power in the late 11th and early 12th centuries CE. As the crowning jewel of a new architectural scheme, King Davit IV constructed the Gelati Monastery as a symbol of political, social, and religious power in medieval Georgia. King Davit IV’s son, King Demet’re I, finished the monastery in the 12th century and added to its construction with one fundamental piece, the iron gates of Ganja. The gates, taken by King Demetrius I from the Islamic city of Ganja in 1139 CE as a spoil of war, were placed next to the grave of King Davit IV Aghmshenebeli. My paper investigates the symbolic importance of the gates from Ganja in its original context for the local Ganjans and what it later meant to the Georgians. I also address the types of peoples involved with the transformation of the gate’s power as it moved locations. These gates have an Arabic inscription on them that indicates the original purpose of the gates for the Islamic ruler of Ganja. A translation of the Arabic script on the gates is also given in my paper. Finally, I demonstrate how the meanings of the gates of Ganja changed as King Demet’re I moved them from Ganja to their final destination within the Gelati complex and how those meanings related to the political landscape that the Medieval Georgian Kingdom sought to create.
Maturation of a Discipline
Authors: Walker Bethany J.
Published: July 2023

In celebration of the ten-year anniversary of the journal, this brief editorial note reviews the ways the field of Islamic archaeology has developed in the last decade, and the ways in which the journal has generated growth, facilitated innovation and collaboration, and given visibility to the field.
Support for Jewish matters. The Humanitarian Society Humanitas B'nei B'rith in Przemyśl in the Second Polish Republic
Authors:   Instytut Historii, Kolegium Nauk Humanistycznych, Uniwersytet Rzeszowski, Wierzbieniec Wacław
Published: July 2023

Przemyśl, in 1931 inhabited by 17,326 followers of Judaism accounting for 34% of its total population, was a medium-sized Polish town, where a major role was played by Jewish elites, including lawyers, doctors, entrepreneurs, teachers etc., supporters of the Zionist movement. The Jewish elites of Przemyśl were associated with the Humanitarian Society Humanitas B’nei B’rith founded in 1924, as a part of the larger and highly recognised international organization B’nei B’rith. The Society is noteworthy for a number of reasons. It was one of the most active B'nei B'rith organisations operating in the Second Polish Republic. Joined by and integrating the local Jewish elites, the Society provided a platform for activities of local, regional and, at times, international importance in support for the Jewish community. In Przemyśl the Society was involved in charitable activities, mainly aimed to benefit orphans and the poor, and it conducted a variety of cultural and educational activities. Particularly worthy of notice is the fact that, as an opponent of antisemitism, Humanitas played a very important role within the local Jewish community of Przemyśl.
Play, Defiance and Imagination As Forms Of Knowledge Production : Examining Bidesiya As Folk Theatre and Its Pedagogical Implications in Classrooms Of Literature
Authors: Chakraborty Pallabi
Published: July 2023

India houses a number of folk theatrical forms that are simple and closer to the rural milieu. After the decline of Sanskrit classical drama in India, from the 14th to the 19th century, folk theatre emerged in myriads of rural languages. These theatrical forms
can be categorised under two broad genres, viz., "Ritual Theatre" that was religious in nature, and the "Theatre of Entertainment," which was more secular in mood. One such example of the secular form is Bidesiya, the dynamic and popular theatre of Bihar. Bidesiya, like the name
suggests, revolves around the "bides" / "pardes," i. e., foreign land / homeland dichotomy. Bidesiya emerged and was given shape by Bhikhari Thakur, the highly-acclaimed poet, playwright, and actor, and aimed at disseminating some kind of social message through the plays. Bidesiya
also makes use of a plethora of folk songs that are rooted in Bihar's soil, and these plays were primarily performed by actors belonging to lower-caste communities. The most crucial aspect of Bidesiya is that this folk theatrical form is fundamentally radical and fluid in terms of how
it deals with gender. Bidesiya showcases Launda naach — or the dance native to Uttar Pradesh and Bihar that is performed by female impersonators — as a powerful theatrical technique. The present paper seeks to scrutinise Bidesiya as a gender-fluid folk theatrical
form of India, and further explores the manner in which Bidesiya problematises the essentialist notion of fixed gender identity. The paper, therefore, begins with an elaborate discussion on the origin of Bidesiya, and moves on to study its various aspects, including the structure
of the plays and the performers' troupes, the "men's" and "women's" folk songs which are associated with the genre, and the underpinnings of the staged performances. The paper then investigates the obfuscation of gender by the actors, visible in Launda Naach — the central element
of Bidesiya plays — and the presentation of the songs, written from feminine perspective, by men. The concluding section of the paper highlights the pedagogical implications of Bidesiya and its relevance in classrooms, with a special emphasis on how gender is revealed as
performative in the plays. Introducing Bidesiya in classroom education resists didacticism by promoting hands-on learning, creates a space for the students to locate themselves within the broad spectrum of gender identities, and also indulges imaginative voyages, as this paper will
show.
Influence of Temperature and Orientation on Elastic, Mechanical, Thermophysical and Ultrasonic Properties of Platinum Group Metal Carbides
Authors: Singh Anurag , Singh Devraj
Published: July 2023

The elastic, mechanical, thermophysical and ultrasonic properties of platinum group metal (pgm) carbides XC (X = rhodium, palladium, iridium) have been investigated at room temperature. The Coulomb and Born-Mayer potential model was used to compute second- and third-order elastic constants (SOECs and TOECs) at 0 K and 300 K. The obtained values of SOECs were used to evaluate mechanical properties such as Young’s modulus, bulk modulus, shear modulus, Pugh’s indicator, Zener anisotropic constant and Poisson’s ratio at room temperature. The materials show brittle nature as the value of Pugh’s indicator for pgm carbides is ≤1.75. The values of SOECs were used to compute the ultrasonic velocities along <100>, <110> and <111> directions for the longitudinal and shear modes of wave propagation. Further, the values of Debye temperature, thermal conductivity, specific heat per unit volume, energy density, average value of ultrasonic Grüneisen parameter, thermal relaxation time and non-linear parameter were calculated with the help of SOECs, TOECs, ultrasonic velocities, density and molecular weight. Finally, the ultrasonic attenuation due to phonon-phonon interaction and due to thermoelastic relaxation mechanisms were calculated with the use of all associated parameters. The calculated values of elastic, mechanical, thermophysical and ultrasonic properties are compared with available literature and discussed.