bluuebunny/crossref_metadata_2025 huggingface dataset:
GOG3069: Phase 2 study of alpelisib and fulvestrant for PIK3CA-mutated estrogen receptor (ER)-positive endometrioid endometrial cancers.
Authors: Gaillard Stephanie , Sill Michael , Klein Jennifer , Reid Thomas , Callahan Michael , Fehniger Julia , Sobecki Janelle , Gold Michael A. , Herzog Thomas J , Slomovitz Brian M. , Matulonis Ursula A.
Published: July 2024

TPS5639

Background: Treatment options for persistent, metastatic, or recurrent endometrial cancer continues to evolve as we learn more about the molecular landscape of this disease. Recent studies have shown a benefit to endocrine-based combinations such as aromatase inhibitors with mTOR or CDK4/6 inhibitors especially in patients who had not received prior chemotherapy ( 1– 3). The presence of oncogenic PIK3CA mutations have been shown to impact response to aromatase inhibitors in breast cancer. The combination of alpelisib and fulvestrant was approved for the treatment of metastatic hormone receptor-positive, HER2-negative breast cancer harboring oncogenic mutations in the PIK3CA gene that progressed on prior endocrine therapy( 4). PIK3CA mutations are commonly identified in endometrial cancers and may similarly confer endocrine resistance. GOG3069 is a phase II trial designed to evaluate the efficacy and safety of alpelisib and fulvestrant in a biomarker-selected endometrial cancer patient population. Methods: This is a phase II non-randomized, open label, multicenter, two-stage study. Eligible patients must have advanced (FIGO 2014 Stage III or IV), persistent, or recurrent endometrial carcinoma with measurable disease by RECISTv1.1 criteria. Patients cannot be curable by surgery or radiotherapy. Disease must be of endometrioid histology with positive expression of estrogen receptor (defined as ≥1% of tumor cells demonstrating positive nuclear staining by immunohistochemistry) and oncogenic PIK3CA mutation. Patients may have received no more than 3 prior lines of therapy including 1 prior line of systemic chemotherapy. Enrolled patients will receive treatment with alpelisib 300mg orally daily and fulvestrant 500mg IM on Day 1 and Day 15 of Cycle 1, then 500mg IM on Day 1 of each 28-day cycle. The primary endpoint is overall response rate as measured by RECISTv1.1-defined tumor response. Secondary endpoints include safety, tolerability, progression-free survival, duration of response, and 24-month overall survival rate. GOG3069 activated in November 2023 and expects to enroll across 15 US sites. The statistical plan uses a conditional stratified design factoring differing probabilities of response based on whether the patient had prior chemotherapy exposure. ClinicalTrials.gov Identifier: NCT05154487 References: 1. B. M. Slomovitz et al., Gynecologic Oncology. 164, 481–491 (2022); 2. P. A. Konstantinopoulos et al., J Clin Oncol. 41, 599–608 (2023); 3. G. Colon-Otero et al., ESMO Open. 5, e000926 (2020); 4. F. André et al., N Engl J Med. 380, 1929–1940 (2019). Clinical trial information: NCT05154487 .
A phase 2 study of ipatasertib in combination with pembrolizumab for first-line treatment of recurrent or metastatic squamous cell cancer of the head and neck.
Authors: Thomas Jacob Stephen , Yang Bruce Justine , Li Zujun , Lorch Jochen H. , Phillips Tanyanika , Villaflor Victoria , Ruel Christopher , Palmer Joycelynne , Gutkind J. Silvio , Villalona-Calero Miguel Angel , Colevas Alexander Dimitrios
Published: July 2024

TPS6117

Background: Single agent pembrolizumab in relapsed / metastatic head and neck squamous cell carcinoma (R/M HNSCC) has an estimated ORR of 19% and median OS of 13.6 months. There are several factors which may influence which patients respond to antibodies targeting the PD-1 axis. Regulatory T cells (Tregs) play a significant role in an immunosuppressive tumor microenvironment. Anti-PD-1 antibodies induce Treg activation in part through AKT pathway activation, which may contribute to low response rates to checkpoint inhibitor therapy. AKT blockade selectively inhibits the proliferation of human Tregs. Additionally, inhibition of the PI3K-AKT-mTOR pathway limits myeloid-derived suppressor cells (MDSC) infiltration and differentiation, and boosts CD8+ T cell memory and effector function. Ipatasertib is an oral highly selective small-molecule inhibitor of all three isoforms of AKT. This phase 2 trial is designed to compare progression-free survival (PFS) in first line R/M, HNSCC patients treated with the combination ipatasertib and pembrolizumab versus pembrolizumab monotherapy treatment. Methods: In this open-label randomized phase 2 multicenter trial, patients with R/M HNSCC are treated with pembrolizumab 200mg on day 1 +/- ipatasertib 400mg QD days 1-14 of 21-day cycles. Patients must have PD-L1 CPS score ³ 1, have measurable disease per RECIST 1.1, and consent to on-treatment biopsy. Patients will be excluded if they have received prior systemic therapy for R/M HNSCC, cannot swallow a pill, or require insulin for diabetes. The primary objective is to compare the PFS between the two arms. We will estimate the relative hazard ratio associated with ipatasertib plus pembrolizumab compared to pembrolizumab alone using the Cox Model where randomized treatment assignment is the only variable in the model. Secondary objectives include ORR, safety and tolerability of the combination, and changes in tumor immune cell infiltration, AKT signaling, and changes in peripheral blood immune cells. Ultimately, a total of 48 patients will be enrolled, with 24 patients in each cohort. To date, a total of 22 patients have been enrolled from 15 sites. Accrual is ongoing (NCT05172258). Clinical trial information: NCT05172258 .
eVOLVE-HNSCC: A global phase 3 study of volrustomig as sequential therapy for unresected locally advanced head and neck squamous cell carcinoma (LA-HNSCC) following definitive concurrent chemoradiotherapy (cCRT).
Authors: Haddad Robert I. , Ruscica Dario , Visa Alexandra , Li Xia , Licitra Lisa F.
Published: July 2024

TPS6120

Background: Currently there are no approved maintenance therapies for patients (pts) with unresected LA-HNSCC following definitive cCRT. The PD-1 inhibitors pembrolizumab and nivolumab are licensed for treatment of pts with recurrent or metastatic HNSCC who have progressed on or after a platinum-based therapy. Dual inhibition of CTLA-4 and PD-L1 is approved in solid tumors including renal cell carcinoma (RCC), NSCLC, and melanoma, and has shown a numerical trend towards improved survival in first-line pts with recurrent/metastatic HNSCC whose tumors express PD-L1. Volrustomig (MEDI5752) is a monovalent, PD-1/CTLA-4 bispecific, humanized IgG1 monoclonal antibody engineered to specifically inhibit PD-1, with increased CTLA-4 blockade on PD-1+ activated T cells compared to PD-1– resting peripheral T cells. In a first-in-human phase 1/2 study (NCT03530397), volrustomig monotherapy showed promising efficacy with acceptable tolerability in advanced clear cell RCC and in combination with chemotherapy in advanced NSCLC. The phase 3, randomized, open-label, multicenter, eVOLVE-HNSCC study will evaluate the efficacy and safety of sequential therapy with volrustomig compared with observation in pts with unresected LA-HNSCC who have not progressed after receiving definitive cCRT (NCT06129864). Methods: Key eligibility criteria include histologically or cytologically confirmed, unresected LA-HNSCC with no evidence of metastatic disease, i.e. AJCC 8th edition (TNM staging system) stage IVA/B cancers of the hypopharynx, oral cavity, larynx or HPV-negative oropharynx, or stage III HPV-positive oropharynx cancer; age ≥18 years; WHO/ECOG performance score of 0 or 1; and adequate organ and bone marrow function. Key exclusion criteria include requiring further treatment with curative intent after definitive cCRT, resected LA-HNSCC, recurrent/metastatic disease, and >1 primary tumor. Following initial screening and definitive cCRT (cisplatin or carboplatin + paclitaxel or carboplatin + 5-FU, plus concomitant radiotherapy), approximately 1145 pts whose disease has not progressed within 12 weeks of the last dose of cCRT will be randomized 1:1 to Arm A or B. Arm A will receive volrustomig intravenously every 3 weeks for a maximum of 12 months or 18 cycles, or until RECIST v1.1-defined radiological progressive disease (PD) or unacceptable toxicity. Arm B will undergo observation for a maximum of 12 months or until PD. The primary endpoint is PFS in pts with PD-L1-expressing tumors. Secondary endpoints include PFS in all randomized pts, OS in pts with PD-L1-expressing tumors and in all randomized pts, PFS2, safety, patient-reported outcomes, pharmacokinetics, and immunogenicity. Exploratory biomarker analyses will also be conducted. Enrollment began in December 2023. Clinical trial information: NCT06129864 .
Association Between Social Determinants of Health and Cancer Treatment Delay in an Urban Population
Authors: Zhang Faye G. , Sheni Risha , Zhang Chenxin , Viswanathan Shankar , Fiori Kevin , Mehta Vikas
Published: July 2024

PURPOSE

Delays in oncologic time to treatment initiation (TTI) independently and adversely affect disease-specific mortality. Social Determinants of Health (SDoH) are increasingly recognized as significant contributors to patients' disease management and health outcomes. Our academic center has validated a 10-item SDoH screener, and we elucidated which specific needs may be predictive of delayed TTI.

METHODS

This is a retrospective cohort study at an urban academic center of patients with a SDoH screening and diagnosis of breast, colorectal, endocrine/neuroendocrine, GI, genitourinary, gynecologic, head and neck, hematologic, hepatobiliary, lung, or pancreatic cancer from 2018 to 2022. Variables of interest included household income, tumor stage, and emergency department (ED) or inpatient admission 30 days before diagnosis. Factors associated with delayed TTI ≥45 days were assessed using multivariable logistic regression.

RESULTS

Among 2,328 patients (mean [standard deviation] age, 64.0 (12.8) years; 66.6% female), having >1 unmet social need was associated with delayed TTI (odds ratio [OR], 1.68; 95% CI, 1.54 to 1.82). The disparities most associated with delay were legal help, transportation, housing stability, and needing to provide care for others. Those with ED (OR, 0.49; 95% CI, 0.44 to 0.54) or inpatient (OR, 0.54; 95% CI, 0.50 to 0.58) admission 30 days before diagnosis were less likely to experience delay.

CONCLUSION

Delays in oncologic TTI ≥45 days are independently associated with unmet social needs. ED or inpatient admissions before diagnosis increase care coordination, leading to improved TTI. Although limitations included the retrospective nature of the study and self-reporting bias, these findings more precisely identify targets for intervention that may more effectively decrease delay. Patients with SDoH barriers are at higher risk of treatment delay and could especially benefit from legal, transportation, caregiver, and housing assistance.
Understanding the Concept of Being in general: From Being and Time back to Young Heidegger
Authors: Filippopoulos Yorgos G.
Published: July 2024

This paper exhibits a way of understanding Heidegger’s concept of being in general [Sein überhaupt] – the central aim of Being and Time’s questioning – by getting insight into his early years. I argue that the term “being” [Sein] as Heidegger understands it in the early 1920s describes the meaningful relation between humans and the things of their surrounding world which is given to us as a fact. I maintain that Sein überhaupt refers to this fact, i.e., the fact that every particular being is always with a certain meaning for us. I come to this conclusion by exploring (1) Heidegger’s early analysis of Umwelterlebnis, (2) his early description of medieval transcendentia, (3) his critique of formalization and the introduction of formal indication. Lastly, (4) I observe the way Heidegger introduces the concepts of Sein and Sein überhaupt pointing to the simple fact of beings’ being in meaningful relation to us.
Kant’s Thought Formation and the Role of the Mind: A Groundwork for Development
Authors: Onah Ikechukwu , Ugwu Anayochukwu Kingsley
Published: July 2024

This paper argues that no form of meaningful development can be discussed without an incursion into the realm of consciousness, from which ideas emanate. This paper demonstrates that human civilization is driven by notions such as ideas, imaginations, concepts, plans, and projects which are germane to social development. An examination of Kant’s theory of concept formation reveals that though objects are given to us by means of sensibility, it is through the understanding that concepts arise. The mind therefore becomes the ‘breeding’ ground from which our ideas are generated and organized. In Kant’s analysis of the faculty of understanding, he noted that there are a priori pure intuitions and sets of categories such as Quality, Relation, Modality that organize particular sensations into unified objects of experience. This capacity of the mind enables it to produce or generate ideas within its own operations. Ideas generated are used to recreate our world. This paper provides a conceptual framework to explicate the foundation of development. Using the method of analysis, this essay concludes that the basis of development − social, economic, and cultural − is hinged on the nature and role of the mind.
“The Knight in the Panther’s Skin” by Shota Rustaveli: Salutogenic Aspects
Authors: Shengelia Ramaz , Jojua Levan
Published: July 2024

The article provides a discussion of the specific salutogenic aspects of medical knowledge in Shota Rustaveli’s “The Knight in the Panther’s Skin” – a distinguished piece of Georgian literature. Consideration of specific passages from the poem and corresponding commentary demonstrates the author’s medical knowledge, as he stresses the significance of positive emotions, a healthy environment, and mood on human health, thus having a therapeutic effect.. Regarding the knowledge reflected in similar scientific literature, which is significant for the history of Georgian medicine, the work offers a more specific and, in some cases, newer vision of the salutogenic aspects in “The Knight in the Panther’s Skin”. Along with the author’s knowledge, we emphasise the fact that during that period, there was a logical link between the medical-biological thinking of the era known as the “Golden Age”. This connection represents a natural expression of the level of the scientific sphere, simultaneously with cultural and political progress in the country. In addition to providing an overview of specific medical areas in “The Knight in the Panther’s Skin”, the article will explore the scientific and other literature of the era and a later period, where similar approaches are described. The issues discussed in the article, regarding their nature and different aspects, could be of interest for studying the history of medicine of that specific era.
Poetic recipes from Nidāʾī, an important sixteenth-century physician, in Durr-i Manzūm
Authors: Balat Ayşe , Acıduman Ahmet
Published: July 2024

It has been known that some of the medical works in the Islamic world in the Middle Ages were composed in verse to create concise information, be easily memorised, and be beneficial for students and the public. This practice has also been observed in Turkish medicine throughout history. The present study aims to introduce Physician Nidā’ī from Ankara, an important sixteenth-century physician, and his renowned poetic work, Durr-i Man ūm, focusing on the sections related to urinary system problems. In this study, we evaluated Durr-i Man ūm, which has many copies in Turkish and European libraries and has been found in Istanbul Süleymaniye Manuscript Library, Nuruosmaniye Collection, Nr. 3556. Nidā’ī has poetic compositions regarding six common nephrological problems: Urinary incontinence, bedwetting in children, haematuria, urinary retention, urination difficulty, and bladder stones. Every subject consisted of a different number of couplets; the difficulty of the disease was briefly mentioned in some couplets, and then appropriate compositions were written in detail in a poetic style. Nidā’ī used poetic recipes excellently and wanted to show that medicine is not an incomprehensible and complicated science by recommending concise and straightforward treatments for certain diseases. The fact that it was copied until the beginning of the nineteenth century, with numerous copies available in both national and international libraries, demonstrates that his work is readily comprehensible to both the public and medical professionals, thereby earning it considerable respect.
Η διερεύνυση του φαινομένου της κρίσης εμπιστοσύνης ως δομικού στοιχείου συγκρότησης της επαγγελματικής ταυτότητας του εκπαιδευτικού
Authors: Παναγόπουλος Επαμεινώνδας
Published: July 2024

Στην παρούσα διδακτορική διατριβή επιχειρείται η παρουσίαση και η ανάλυση των επιπέδων εμπιστοσύνης στη σχολική μονάδα, δηλαδή τόσο η ύπαρξη σχέσεων εμπιστοσύνης και ο βαθμός στον οποίο υφίστανται, όσο και η ποιότητα που τις χαρακτηρίζει. Ιδιαίτερη έμφαση δόθηκε στις διαφοροποιημένες επαγγελματικές ταυτότητες και στο εάν αυτές σχετίζονται με τα επίπεδα εμπιστοσύνης. Ξεχωριστής σημασίας για τη μελέτη είναι η δομική συνθήκη του συνεχούς της κρίσης. Σημαίνουσας βαρύτητας φορτίο προσδίδει στη μελέτη και το γεγονός ότι το κοινωνικό, οικονομικό και πολιτικό πλαίσιο στην Ελλάδα τα τελευταία χρόνια χαρακτηρίζεται από ρευστότητα. Ως μεθοδολογική προσέγγιση επιλέχθηκε η έρευνα μεικτών μεθόδων, δηλαδή ο συνδυασμός της ποσοτικής προσέγγισης με την ποιοτική. Ως εργαλεία συλλογής ερευνητικών δεδομένων χρησιμοποιήθηκαν το ερωτηματολόγιο και η συνέντευξη. Στον πληθυσμό-στόχο περιλαμβάνονται εκπαιδευτικοί και διευθυντές σχολικών μονάδων Πρωτοβάθμιας Εκπαίδευσης που βρίσκονται στην Περιφέρεια Δυτικής Ελλάδας. Το δείγμα της έρευνας εξήχθη μέσα από τους συγκεκριμένους πληθυσμούς μέσω της τυχαίας δειγματοληψίας (με αναφορά στο σύνολο του πληθυσμού) που εξασφαλίζει την αντιπροσωπευτικότητα του δείγματος. Η διεξαγωγή της συγκεκριμένης έρευνας, συμπεριλαμβανομένης της ποσοτικής προσέγγισης και της ποιοτικής προσέγγισης, πραγματοποιήθηκε από τον Μάϊο του 2023 έως και τον Φεβρουάριο του 2024.
Confronting Modernity and the Transformation of the Muslim Family in Ömer Nasuhi̇ Bi̇lmen’s Writings in the 20th Century Ottoman State
Authors: Yaşar Hakime Reyyan
Published: July 2024

During the 19th and 20th centuries, the Ottoman State underwent a process of modernization driven by political, legal, and social reforms. This period was marked by a cautious approach to change by Ottoman scholars, including Ömer Nasuhi Bilmen. Bilmen was a highly influential Muslim intellectual and Islamic legal scholar during the late Ottoman era and the early years of secular Turkey. This article examines Bilmen’s confrontation of modernity and his responses to societal changes through specific issues relevant to his time in the late Ottoman era. It discusses his role in addressing obstacles, his observations of ongoing transformations, and his critiques of European hegemony and modernization. The study focuses on Bilmen’s articles written in Ottoman Turkish between 1920 and 1922, particularly on marriage, divorce, polygamy, and population growth policies.
Raëlism: An Unconventional Religious Pathway to Transhumanism
Authors: Yeşilyurt Büşra , Yeşilyurt Muhammet
Published: July 2024

Raëlism is a controversial new religious movement that originated in France in the 1970s and has since spread around the world. The movement’s core tenets are rooted in science, technology, and freedom and can be summarized as a blend of science and spirituality, millenarianism, revelation, story, pseudoscience, and reinterpretation. Raëlians believe in the extraterrestrial origin of humanity and promote the pursuit of higher consciousness, inner peace, individual empowerment, and peace-building. To this end, the movement offers a series of seminars that aim to provide a transformative experience for participants and leads various social initiatives and projects at a global level. Although Raëlism has gained popularity among some individuals, it has also been the subject of substantial criticism and controversy, particularly because of its unconventional views on sexuality and its alleged support for human cloning and genetic engineering. Nonetheless, the movement continues to be a subject of interest and scrutiny for scholars, journalists, and the curious. This article provides an overview of the history, ideology, and practices of the Raëlian Movement and its relationship with transhumanism.
Zmierzch Europy czy ofensywa Wschodu – ukraińscy intelektualiści w poszukiwaniu Ukrainy na mapie nowej Europy Wschodniej po 1945 r.
Authors: Korolov Gennadii
Published: July 2024

Artykuł przedstawia zagadnienie postrzegania i rozumienia miejsca Ukrainy na politycznej i geograficznej mapie Europy po drugiej wojnie światowej – od 1945 r. i do upadku komunizmu w 1991. Autor analizuje również kwestię idei i koncepcji Europy Środkowo-Wschodniej w myśli znanych ukraińskich intelektualistów i historyków, jak Borys Krupnycki, Mykoła Czubaty, Jurij Szewelow, Iwan Łysiak-Rudnycki, Roman Szporluk i inni. Celem artykułu jest analiza charakteru, rozwoju i instrumentalizacji miejsca Ukrainy w ukraińskiej myśli emigracyjnej, a także wpływu, jaki wywierały na nie różne koncepcje granic i podziałów.
Wróg cywilizacyjny – obrazy rosyjskiego imperializmu w międzywojennej myśli politycznej Organizacji Ukraińskich Nacjonalistów
Authors: Wojnar Marek
Published: July 2024

Artykuł rekonstruuje w oparciu o teksty publicystyczne stosunek Organizacji Ukraińskich Nacjonalistów wobec rosyjskiego imperializmu w okresie międzywojennym. Działacze OUN oceniali go jako zjawisko stałe, istniejące zarówno w czasach Rosji carskiej, jak i Związku Sowieckiego, obecne również wśród rosyjskich ugrupowań emigracyjnych. W ocenie ukraińskich nacjonalistów imperializm ten stanowił produkt specyficznej rosyjskiej duchowości, a tym samym charakteryzowały go cechy orientalne. Uprawianą w jego ramach politykę wobec Ukrainy uznawali zaś za kolonialną. W drugiej połowie lat trzydziestych w myśli OUN upowszechniło się przekonanie o daleko posuniętym kryzysie rosyjskiego imperializmu.
Historia międzykropelkowa – o pracy Jarosława Hrycaka „Uporać się z przeszłością: globalna historia Ukrainy”
Authors: Adamski Łukasz
Published: July 2024

Artykuł stanowi krytyczną analizę najnowszej popularnonaukowej syntezy historii Ukrainy napisanej przez Jarosława Hrycaka z perspektywy historii powszechnej. Zaletami pracy są lekki styl oraz niesztampowe interpretacje historii Ukrainy, natomiast wadą – wiele niedociągnięć warsztatowych, w tym niespójność metodologiczna wywodów Autora oraz liczne błędy faktograficzne i interpretacje historii stosunków polsko-ukraińskich będące w ogromnej mierze powieleniem klisz zaczerpniętych od ukraińskich historyków nacjonalistycznych lub sowieckich.
Micro y macrosintaxis del español. La oración compleja
Authors: Fuentes Rodríguez Catalina
Published: July 2024

La investigación sobre el discurso se va extendiendo en diferentes direcciones, integrando la pragmática y la interacción de factores diversos. Sin embargo, la existencia de una sintaxis del discurso no ha tenido el mismo desarrollo. Esta obra se centra en un tema tradicional, la oración compleja, pero lo aborda desde un enfoque integrador micro-macrosintáctico. Se describen los fundamentos de esta metodología para analizar las funciones que cumplen las diversas construcciones oracionales en el enunciado, así como su comportamiento en las macroestructuras informativa y argumentativa. El resultado es una visión integral de la comunicación realizada en la que la intención comunicativa del hablante diseña la estructuración y relación de los esquemas oracionales.
Breeding Place Preference of Aedes sp. at the Tsunami Area Banda Aceh City
Authors: Agustina Elita , Emil Muhammad Farhan Putra
Published: July 2024

The rebuilding of the post-tsunami community residential in Banda Aceh   has had an impact on the emergence of Aedes habitat. The Aedes choose a container to breed based on biotic and abiotic factors that support their survival. This study aimed to the identification of Aedes species, location and type positive containers Aedes larvae at the area tsunami Banda Aceh. Methods an observational study of a cross-sectional approach involved 100 houses. Data larvae were collected using the single larvae method. Observations of containers were carried out in natural and artificial containers, indoors and outdoors. Positive containers Aedes larvae were recorded for the type of container and location found. The result of the study found two species of Aedes, there were Aedes aegypti and Aedes albopictus. Larvae of Ae. aegypti was generally found in containers indoors (71%) and containers outdoors (29%). Larvae of Ae. albopictus were found in containers indoors (10%) and containers outdoors (90%). The types of positive breeding containers of Ae. aegypti found were bathtubs (71%), discarded tires (9%), plastic drums (5%), water tanks (5%), watering pots (5%) and flower pots (5%). The containers were observed found larvae of Ae. albopictus were the bucket (30%), plastic drum (20%), bathtub (10%), discarded tires (10%), pet drinking place (10%), mineral water jar (10%) and coconut shells (10%). Monitoring of containers indoors and outdoors that can hold water is important supports the eradication program breeding places of Ae. aegypti and Ae. albopictus.
Strategi Guru dalam Meningkatkan Kemandirian Belajar Siswa dalam Pembelajaran Daring Di Sekolah Dasar
Authors: Rahayu Virnanda , Suyatno Suyatno
Published: July 2024

Kemandirian belajar merupakan faktor penting dalam menentukan pembelajaran daring siswa. Seorang guru harus memiliki strategi yang inovatif dalam membantu kemandirian siswa dalam proses belajar. Penelitian ini bertujuan: 1) mendeskripsikan aspek-aspek kemandirian belajar siswa, dan 2) mengkaji strategi guru dalam meningkatkan kemandirian belajar siswa selama pandemi covid-19 di SD Muhammadiyah Suronatan Yogyakarta. Penelitian yang digunakan adalah penelitian kualitatif dengan pendekatan studi kasus. Subjek penelitian yaitu kepala sekolah, guru kelas, siswa dan orangtua. Teknik pengumpulan data yaitu wawancara, observasi, dan dokumetasi. Teknik analisis ini terdiri dari tiga kegiatan yaitu reduksi data, penyajian data, dan verifikasi atau pemeriksaan kesimpulan. Hasil penelitian menunjukkan bahwa: 1) kemandirian belajar di SD Muhammadiyah Suronatan dapat dibedakan menjadi kemandirian siswa dalam mengerjakan tugas, kemandirian siswa dalam beribadah, kemandirian siswa dalam membantu pekerjaan rumah, dan kemandirian siswa dalam mengikuti lomba-lomba yang ada diluar sekolah. 2) strategi guru dalam meningkatkan kemandirian belajar yaitu dilakukan melalui pemanfaatan teknologi informasi dalam pembelajaran, median pembelajaran inovatif, dan strategi pembelajaran interaktif.
Developing an Online Learning Module to Aid in Student Learning and Results
Authors: Mutiarani Zahra Rastya , Sumiyadi Sumiyadi , Cahyani Isah , Sastromiharjo Andoyo , Nuphanudin Nuphanudin
Published: July 2024

Self-regulated e-learning modules are an innovative teaching method to increase student success and results in light of the desire to include technology in nursing education and the rising demand for online training. According to a learning requirements analysis, the addition of a self-directed, self-paced e-learning module might give students a way to more adequately get ready for a scenario simulating pediatric dehydration with medium realism. Three members of the faculty—a faculty topic specialist, a faculty content consultant, and a librarian/instructional designer—were assembled into a collaborative, interdisciplinary project team. Using the notion of self-regulated learning, the team created an online learning module. The purpose of this module is to better prepare undergraduate nursing students for pediatric simulation. It is an asynchronous, standalone, self-paced supplement. The inclusion of an online learning module will improve student engagement with the subject matter and encourage greater self-directed learning.
Integrating Cultural Values Into Buddhist Sunday School Learning System
Authors: Andanti Maria Fransisca , Sutikyanto Sutikyanto
Published: July 2024

This paper draws upon the possibility of integrating cultural values into Indonesia's Buddhist Sunday School (BSS) learning system. It employed George’s (2008) library research methods consisting of motivation or assignment, imagination, research questions (brainstorming), research plan (strategy), reference works and databases (tools and tactics), sources, evaluation, insight, thesis, argument and outline, and drafting and revising. By reviewing 25 journal articles and books regarding with culture and education, this paper proposed three things to establish cultural-based religious learning in BSS, which are strengthening cultural content and values in the learning process, building a community-based learning, and involving parents.
Briefing: School attendance drive
Authors: Hayes Derren
Published: July 2024

The government has published guidance to improve school attendance with new duties on councils
End decline in youth apprenticeship starts
Authors: Coulthard Lisa Morrison
Published: July 2024

Lisa Morrison Coulthard, research director at the National Foundation for Educational Research
Relationships with the Court
Authors: Harris Alexandra Conroy
Published: July 2024

Alexandra Conroy Harris, legal consultant at CoramBAAF, explains how the charity is working with local authorities and judges to improve understanding of care orders so the right one is used
Targeting Autophagic Pathway in Oral Cancer Therapy Through Phytoconstituents: A Short Review
Authors: Satpathy Soumya , Bhuyan Sanat Kumar , Bhuyan Ruchi
Published: July 2024

Oral cancer was recognized as the most common type of cancer in South Asian countries including India. As concurrent chemoradiotherapy leads to various associated new problems, there is always a need for improved therapies without side effects. Natural plant products used since ancient times may fill the gap. Phytoconstituents can activate various cell death pathways, such as apoptosis, autophagy, or pyroptosis to treat oral tumors. Numerous studies have already been done to date to enlighten the detailed mechanism of the use of phytoconstituents in these cell-signaling pathways. As the majority of the studies emphasized the apoptotic pathway, the least reports are found on autophagy. ‘AMPK’ and ‘mTOR’ have been acknowledged to be the key signaling compounds that modulate autophagy. Therefore the objective of this article is to discuss the mechanism of autophagy concerning phytoconstituents in the treatment of oral carcinoma.
Quaternary Ammonium Disinfectants: Current Practices and Future Perspective in Infection Control: Review Article
Authors: Kaur Gaurav Sharma and Kiranjeet
Published: July 2024

Hospital-acquired infections (HAIs) are one of the most tangled difficulties in advanced clinical practices. These infections lead to financial implications and have a significant impact on morbidity and mortality. It is very difficult to eradicate the HAIs however both disinfection and sterilization account for the best measure to control HAIs. Of all the disinfectants in use, one of the chemical disinfectants which seem to be user-friendly, non-corrosive, and used extensively are Quaternary ammonium compounds (QACs) based disinfectants. To improve the efficacy of these disinfectants and tackle the challenge of antimicrobial resistance (concerning QACs), from time to time newer QACs disinfectants were introduced which are termed as first, second, third, fourth, and fifth-generation QACs disinfectants. Manufacturers of these newer generations QACs disinfectants claim these compounds as high-level, broad-spectrum disinfectants while leading healthcare agencies like the Centre for Disease Control & Prevention (CDC) mention QACs as mild disinfectants and not sporicidal. Sadly, the antimicrobial efficacy of QACs has been largely assessed using old methods like phenol coefficient methods & suspension methods, and not using an internationally standardized method. These loopholes raise a lot of queries about the true efficacies of the QACs and thus, increase the chances of the development of resistant HAIs. Therefore, there is an urgent need for better and standardized methods to study the efficacy of different generation QACs. The present review discusses the status of currently available methods and gaps in the literature that would be useful to highlight the potential use of QACs for infection control and prevention in better ways.
Scavenger Receptors: Different Classes and their Role in the Uptake of Oxidized Low-Density Lipoproteins
Authors: Babakr Abdullatif Taha
Published: July 2024

Oxidation of lipoproteins marks a fundamental early phase in atherosclerosis development, a condition distinguished by plaque build-up in the arteries. It is widely accepted that the oxidation of low-density lipoprotein (LDL) plays a pivotal role in atherosclerosis progression. Oxidized LDL (Ox-LDL) exhibits numerous atherogenic characteristics, leading to endothelial dysfunction, the creation of foam cells, and inflammation in the arterial wall. The crucial interaction between Ox-LDL and specific receptors on endothelial cells is key to initiating these processes. In this article, we're going to delve into the various LDL receptors that play a crucial part in the uptake and metabolism of LDL, emphasizing their significance in the development of atherosclerosis. The Cochrane database, Embase, PubMed, Scopus, Google Scholar, Ovid, and other databases were thoroughly searched for works addressing scavenger receptors to explore how both native LDL (nLDL) and Ox-LDL engage with these receptors, facilitating the formation and progression of atherosclerotic plaques. We'll then proceed to a more detailed examination of the complex role scavenger receptors play in the uptake and internalization of oxidized low-density lipoproteins (Ox-LDL), and their vital role in the onset of diseases. The review will further cover the identification, categorization, and roles of scavenger receptors, along with their molecular mechanisms. Grasping the complexity of these receptor-ligand interactions is critical for the creation of focused treatments to fight against pathologic conditions such as atherosclerosis and its related health scenarios.
Metabolite Profiling of the Extract and Antimalarial Activity of the Tablets Derived from the Cortex of Alstonia spectabilis
Authors: Taek Maximus M. , Ma’arif Burhan , Muslikh Faisal A. , Maulina Novia , Lalong Paulus R. F.
Published: July 2024

Malaria is a global health concern that threatens many countries. Plasmodium sp. may facilitate human transmission and is currently relatively resistant to chloroquine. The people in Nusa Tenggara, Indonesia, have traditionally employed the cortex of Black Pulai (Alstonia spectabilis) as a treatment for malaria for a considerable period. The objective of this study is to analyze the phytochemical composition of the 96% ethanol extract of A. spectabilis cortex (ASCE) and evaluate the antimalarial properties of tablets derived from A. spectabilis cortex extract (ASCT). A metabolite profile analysis was conducted on ASCE utilizing a UPLC-QToF-MS/MS method. And antimalarial test was conducted on ASCT on mice (Mus musculus) infected with Plasmodium berghei, and the blood smears of the mice were analyzed along with liver tissue damage. The results showed that administering ASCT could reduce the percentage of parasitemia in mice as well as the average liver damage score. This situation is feasible due to the presence of significant compounds in the ASCE that are anticipated to function as antiplasmodium agents, including villalstonine, vincadifformine, and pleiocarpamine. From these findings, one can infer that ASCT, which includes ASCE as its active component, has the potential to serve as a preferred antimalarial medication.
In-vitro Anti-bacterial and Anti-cancer activity of Ocimum tenuiflorum L. leaf Extract Induced Silver Nanoparticles – A study of Characterization Cum Evaluation
Authors: Karthikeyan R. , Haema G. , Vijayan V. , Alamelu V. , Sakthiganapathy M. , Shanmuganathan S. , Cheriyan Binoy Varghes , Saravanan R. , Vijayarajkumar P.
Published: July 2024

Silver nanoparticles were combined with Ocimum Tenuiflorum L. green and purple (Krishna Tulasi) assortments using a single advance that was eco-friendly. Ultraviolet-Visible spectrophotometer, Fourier transform Infra-red, X-Ray Diffraction, Scanning Electron Microscope (SEM), and Energy Dispersive X-ray spectroscope was used to describe the particle nature of integrated AgNps (EDX). A variety of modifications confirmed the nanoparticle arrangement and UV-Visible spectroscopy was used to quantify the Surface Plasmon retention band. In the FTIR, the presence of the aromatic ring's C-H vibration is comparable to the presence of flavonoids and carbonyl gathering in the C-O stretch vibration. The inserted silver nanoparticles can clearly be seen under an SEM microscope, and the particles are estimated to be between l and 100 nm in size. The Energy Dispersive X-ray spectra demonstrate the nanomaterial’s quality. Union is traditional and viewed as proficient as far as response time as well as practicality. The combined nanoparticles were exposed to Anti-microbial and Anti proliferative investigations by in-vitro strategies and showed a portion of the subordinate movement against specific microbes and cancer cells.
Effect of Enterococin – Zinc Oxide Nanoparticles on Gene Expression of rsbA Swarming Genes in Proteus mirabilis isolation Catheter urine.
Authors: Mahdi Sarab Mohammed , Ahmed Mais Emad. , Abbas Adawia Fadhil
Published: July 2024

Urinary tract infections linked to catheters are believed to be caused most frequently by Proteus mirabilis. It produces urease, which greatly increases the potency of catheter occlusion caused by swarming. Pathogenic bacteria use swarming as one of their main virulence mechanisms to evade antibiotics; as a result, there is an increasing need to develop novel antibiotic substitutes. Investigating the possible antibiofilm capabilities of artificial zinc oxide nanoparticles (ZnO NPs) made from E. Faecium was the aim of this study. By generating reductive enzymes, bacterial cells are able to catalyze the biosynthesis process. Bacteriocin-like inhibitory substance (BLIS) was used to create the nanoparticles. AFM, TEM, FESEM, and other analytical tools were used to characterize the synthesized zinc nanoparticles and determine the chemical and physical characteristics of the products. Weak swarming is shown by microorganisms that develop strong swarming. After incubation, the ZnO nanoparticles were incubated for 24 or 48 hours at 37°C at a sub-MIC of 32 µg/ml. After these isolates were treated with zinc nanoparticles, downregulation of rsbA expression was detected via real-time PCR compared to that in the untreated isolates. Zinc oxide nanoparticles can serve as antibacterial agents in a concentration-dependent manner, according to all of the study's findings. This was demonstrated by the notable downregulation of rsbA gene expression, which effectively inhibits the production of biofilms and swarming motility. This was demonstrated by their noteworthy downregulation of rsbA gene expression, which effectively promoted swarmed motility.
Comparison of Anticancer Activity Between Thymoquinone and Tamoxifen , Thymoquinone + Tamoxifen 0n Mcf -7 Cell Line of Human Breast Cancer –An Invitro Study.
Authors: K Neevedha , E Anitha , Gokul Thulasi , Anandan Isswariya , Vivekkumar S Priestly
Published: July 2024

This study aims at evaluating the anticancer effect on the MCF-7 (Michigan Cancer Foundation-7) cell line of human breast cancer using Thymoquinone and Tamoxifen alone as well as in combination therapy by 3-(4,5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide (MTT) Test. NCCS in Pune provided the MCF-7 cell line. The cells were kept at 37°C in a humidified medium of 50µg/ml CO2 in Minimal Essential Medium added with 10percent FBS (Foetal Bovine Serum), streptomycin (100µg/ml), as well as penicillin (100U/ml). MTT-(3-(4, 5-dimethyl-2-thiazolyl)-2, 5-diphenyl tetrazolium bromide) test was conducted on MCF-7 cell line for Thymoquinone and Tamoxifen as sole and combination therapy. Measurements were performed using UV (Ultra-Violet)-spectrophotometer at 570-nanometre absorbance and the content needed for a 50 percent inhibitory concentration (IC50) was calculated and evaluated graphically. IC 50 of Thymoquinone on MCF 7 was found to be at 31.2 µg/ml and Tamoxifen was at 62.5 µg/ml were as in combination therapy the IC 50 was found to be at 7.8 µg/ml. There is a remarkable reduction in concentration to achieve IC 50 percentage in combination therapy with a comparison with individual therapy. Therefore, the combination therapy of Thymoquinone and Tamoxifen on the MCF-7 cell line is more efficacious when compared to individual treatment on cell viability inhibition.
Entrepreneurship, mental disorders and the saga of the adventure gene: debunking the fad of hardwired entrepreneurship
Authors: Agafonow Alejandro
Published: July 2024

This paper disputes the thesis that a self-reported mental condition of apparent genetic origin makes its carriers entertain entrepreneurial intentions and assesses its implications for entrepreneurship-driven economic development. The findings are that the research in question mistakes true causative agents for superficial cause-hiding vectors, thus confusing a self-reported attention-deficit/hyperactivity disorder (ADHD) condition with the cause of entrepreneurial intentions. This is all the more so because ADHD was not properly accounted for, relying instead on the Global University Entrepreneurial Spirit Students Survey (GUESSS), self-administered without diagnostic evidence. Thus, entrepreneurship has been turned on its head, being misrepresented as a hardwired, innate human trait instead of a course of action that hinges on subjective preferences that can be influenced by the structure of rewards shaped by public policy. This misrepresentation may dwell in the so-called ‘hardness bias’, which underestimates the softer but crucial test of the quality of conjectures. The originality of this paper lies in the use of the harmful-dysfunction analysis, showing that the entrepreneurship research in question is based on a bogus notion of disorder.
Shifting Moods and Shifting Discourses: Hopelessness at the Intersection of American Catholicism and Psychology
Authors: Sain Barbara K.
Published: July 2024

ABSTRACT: In his 1971 book, Out of the Depths , William Collins, CSS, recounts his long struggle with anxiety and depression. For Collins, as for other American Catholics in the twentieth century, the experience of hopelessness was influenced by religious and medical discourses that shifted in relation to each other over time. Early in the century Catholic ideas of hope were expressed in the precise categories of neo-Scholasticism. By the end of the century there were multiple Catholic approaches to hope. The same time period saw the integration of psychiatry and psychology into mainstream American culture. As these disciplines were defining themselves and striving for recognition from the scientific and medical establishments, the categories used for mental illness were also changing. From nervous problems and neurasthenia early in the century to schizophrenia, anxiety, and then depression, the vocabulary of emotional and mental problems changed as ideas about their nature and causes developed. Collins's narrative of alternating hopelessness and hope gives insight into how his experience was shaped by his suffering, the social expectations he had internalized, and the institutional frameworks he was navigating. It also gives broader insight into how American Catholics viewed emotional problems in the middle of the twentieth century.
Laser biospeckle method for a fast and reliable microbioassay
Authors: Devi Arti , Kadono Hirofumi , Rajagopalan Uma Maheswari
Published: July 2024

Recently, the direct toxicity assessment (DTA) approach or bioassay has attracted much attention, as it can comprehensively evaluate water toxicity without examining a specific/individual chemical component. Bioassays are used to investigate how organisms respond to pollutants compared to controls. In this technique, a microscopic observation is required to know the critical features such as alive/dead, and swimming ability of microorganisms. As the size of the microorganism becomes smaller, observation becomes more difficult due to the narrower focal depth of the imaging system. In our study, to overcome the difficulties, we propose, to our knowledge, a novel technique for the microbioassay utilizing a biospeckle in the diffraction field generated from its movement. We employed Paramecia caudatum sized around 200–300 µm. The sample cell containing Paramecia was illuminated with a laser light with a diameter 15 mm and wavelength 635 nm. The specular component of the transmitted light was filtered out using a spatial filter placed at the Fourier plane and the biospeckle patterns in the diffraction field were acquired using a CCD camera as a movie. It is obvious that the dynamic properties of the biospeckle precisely reflects the movement of the scattering particles or Paramecia. Paramecia were exposed to HCl solutions with pH7.1, control, to 3.7 where all were dead. The swimming abilities of the Paramecia were successfully evaluated based on the crosscorrelation function of the frames of biospeckle patterns. The advantage of the method is that, owing to the non-imaging system, an enormous number of Paramecia can be processed as a whole, and a statistically significant estimation of the swimming ability of Paramecia under the influence of environmental pollution can be derived immediately.
Profiling of particulate matter transport flux based on dual-wavelength lidar and ensemble learning algorithm
Authors: Li Rongzhong , Wu Songhua , Sun Kangwen , Wang Qichao , Wang Xitao , Qin Shengguang , Fan Mengqi , Ma Li , Hao Yong , Zheng Xiaowei
Published: July 2024

Transport flux (TF) is a significant particulate matter (PM) characteristic. This paper introduces an advanced dual-wavelength polarization aerosol and wind lidar (Wind Flux 3000) capable of independently observing the PM TF. The PM TF observation capability, which allows for simultaneous aerosol and wind measurements, was achieved by integrating a Mie-polarization particle lidar module and a coherent Doppler wind lidar module into a single lidar system. The primary measurement products of the Wind Flux 3000 include particulate extinction coefficient at 532 nm and 1550 nm, volume linear depolarization ratio at 532 nm (δp,532), wind speed (WS), wind direction (WD), vertical speed (VS), turbulence intensity (TI) and mixing layer height (MLH), retrieved by physical and proven algorithms. The PM concentration scales with the measured optical parameters and is also impacted by other environmental or meteorological parameters. Under the framework of the potential relationship between the PM concentration and the above parameters, the PM2.5 and PM10 concentration retrieval models were established using the stacking method of the ensemble learning technique; the models were trained using the in-situ data as true values, while the signal-to-noise ratio (SNR) at 1550 nm, δp,532, WS, WD, VS, the standard deviation of VS, TI, MLH provided by the Wind Flux 3000, as well as the relative humidity and temperature from ERA5, the hours of the day, and a “dust day” flag were used as inputs. The R2, RMSE, and MAE for the comparison between the predicted and true values of the PM2.5 test set are 0.857, 13.52 µg · m- 3, 9.16 µg · m- 3, and those of the PM10 test set are 0.926, 24.75 µg · m- 3, 14.39 µg · m- 3, respectively. The performance of the PM2.5 and PM10 concentration retrieval ensemble models is better than that of individual machine learning algorithms and better than that of the linear model. On 15th March 2023, a strong southeastward dust transport process with dust plume deposition was observed at Qingdao by the Wind Flux 3000. The analyses of the dust event demonstrated the Wind Flux 3000's ability to evaluate the transports of PM quantitatively.