bluuebunny/crossref_metadata_2025 huggingface dataset:
Data-Driven Quantum Approximate Optimization Algorithm for Cyber-Physical Power Systems
Authors: Jing Hang , Wang Ye , Li Yan
Published: June 2022

Quantum technology provides a ground-breaking methodology to tackle challenging computational issues in power systems, especially for Distributed Energy Resources (DERs) dominant cyber-physical systems that have been widely developed to promote energy sustainability. The systems’ maximum power or data sections are essential for monitoring, operation, and control, while high computational effort is required. Quantum Approximate Optimization Algorithm (QAOA) provides a promising means to search for these sections by leveraging quantum resources. However, its performance highly relies on the critical parameters, especially for weighted graphs. We present a data-driven QAOA, which transfers quasi-optimal parameters between weighted graphs based on the normalized graph density, and verify the strategy with 39, 774 instances. Without parameter optimization, our data-driven QAOA is comparable with the Goemans-Williamson algorithm. This work advances QAOA and pilots the practical application of quantum technique to power systems in noisy intermediate-scale quantum devices, heralding its next-generation computation in the quantum era.
Combining blinatumomab and donor lymphocyte infusion in B-ALL patients relapsing after allogeneic hematopoietic cell transplantation: A study of the SFGM-TC
Authors: Chauvet Paul , Paviglianiti Annalisa , Labopin Myriam , labussiere helene , Boissel Nicolas , Robin Marie , Maillard Natacha , Ouachée-Chardin Marie , Forcade Edouard , Poiré Xavier , Chantepie Sylvain , Huynh Anne , BULABOIS Claude-Eric , Leclerc Mathieu , Maury Sébastien , Chevallier Patrice , Cluzeau Thomas , Mear Jean-Baptiste , Cornillon Jerome , Bilger Karin , SIMAND Celestine , Beguin Yves , Rubio Marie-Thérèse , yakoubagha ibrahim , Brissot Eolia
Published: June 2022

Relapsed B-cell acute lymphoblastic leukemia (B-ALL) after allogeneic stem cell transplantation (allo-HCT) still represents a major concern with poor outcomes. The aim of this study is to compare the efficacy and safety of blinatumomab and donor lymphocyte infusion (DLI) versus blinatumomab alone in this setting. This is a multicenter retrospective study from centers of SFGM-TC. All transplanted patients who received blinatumomab salvage therapy were included. Patients who received DLI from 1 month before to 100 days after the starting of blinatumomab were included in the blina-DLI group. Seventy-two patients were included. Medium follow-up was 38 months. Fifty received blinatumomab alone and 22 the association blinatumomab-DLI. Two-year overall survival (OS) was 31% in the blinatumomab group and 43% in the blinatumomab-DLI group (p=0.31). Studying DLI as a time dependent variable, PFS did not significantly differ between the 2 groups (HR:0.7, 95%CI:0.4-1.5). In multivariate analysis, DLI was not a prognostic factor for OS, progression-free survival and progression/relapse incidence. Adverse events and graft-versus-disease rates were comparable in the 2 groups. In conclusion, adding DLI between 1 month before and 100 days after start of blinatumomab is safe and does not seem to improve outcomes in B-ALL patients who relapsed after allo-HCT.
Design and Analysis of a Welding Inspection Robot
Authors: zhang pengyu , Zhang Feng , Xu Pei-Quan , Li Lei-Jun
Published: June 2022

Periodic inspection of weld seam quality is an important step in assessing equipment safety. But this task requires personnel to perform inspection rounds. To save labor costs and improve efficiency, autonomous navigation and autonomous weld inspection robot are developed. The development process involves the design of chassis damping, target detection mechanism, and control system and algorithms. In particular, when performing weld inspection in complex outdoor environments, the robot is required to avoid any obstacles. The problem of planning the inspection route is solved by improving a timed elastic band (TEB) algorithm. The robot is capable of conducting inspection tasks in complex and dangerous environments efficiently.
Point of care-based design and developement of liposome-anchored Teriparatide incorporated gallic acid-grafted gelatin injectable hydrogel for osteoarthritis treatment
Authors: Guoqing Li , Liu Su , Chen Yixiao , Zhao Jing , Xu Huihui , Weng Jian , Yu Fei , Xiong Ao , Udduttula Anjaneyulu , Wang Deli , Liu Peng , Chen Yingqi , Hui Zeng
Published: June 2022

Intra-articular (IA) injection of drugs is an effective strategy in treating osteoarthritis disease. However, the rapid drug loss and high-frequency injections are the main issues. Hence, we verily efforts to design and develop a point of care-based new biofunctional hydrogel by nanoengineer and chemistry approach. In this study, a novel gallic acid-grafted gelatin injectable hydrogel loaded with liposomes-anchored teriparatide (GGA@Lipo@PTH: GLP) was developed with an enzyme-linking method to control PTH release, aimed to alleviate osteoarthritis progress and protect chondrocytes degradation. In vitro studies of the GLP hydrogel promoted ATDC5 proliferation and upregulation of key proteins expression in the PI3K/AKT signaling pathway. Further, in vivo IA injection results of GLP confirmed the controlled release of PTH, promotes the secretion of glycosaminoglycan and protects the cartilage from degradation in DMM mice. Therefore, our study explored that the developed novel GLP hydrogel could be an alternative potential biomaterial in the osteoarthritis treatment.
Multi-scale organization in communicating active matter
Authors: Ziepke Alexander , Maryshev Ivan , Aronson Igor , Frey Erwin
Published: June 2022

The emergence of collective motion among interacting, self-propelled agents is a central paradigm in non-equilibrium physics. Examples of such active matter range from swimming bacteria and cytoskeletal motility assays to synthetic self-propelled colloids and swarming microrobots. Remarkably, the aggregation capabilities of many of these systems rely on a theme as fundamental as it is ubiquitous in nature: communication. Despite its eminent importance, the role of communication in the collective organization of active systems is not yet understood. Here we report on the multi-scale self-organization of interacting self-propelled agents that locally process information transmitted between them by chemical signals. We show that this communication capacity greatly expands their ability to form complex structures, allowing them to self-organize through a series of collective dynamical states at multiple hierarchical levels. Our findings provide insights into the role of self-sustained signal processing for self-organization in biological systems, and open routes to applications using chemically driven colloids or microrobots.
Autologous protein solution injection for knee osteoarthritis: Comparison of clinical results by disease severity
Authors: Kuwasawa Ayano , Okazaki Ken , Noda Kuniko , Nihei Kotaro
Published: June 2022

Background: Autologous protein solution (APS) is made from platelet-rich plasma that extracts high-concentration growth factors and cytokines. Intra-articular APS injection was reported to improve knee osteoarthritis (KOA) pain and function. However, efficacy differences regarding osteoarthritis severity remained unknown.Methods: This retrospective study clinically assessed 228 knees with KOA in the Kellgren–Lawrence (KL) grades 2–4 that underwent APS injection using the Knee Injury and Osteoarthritis Outcome Score (KOOS). A telephone survey was performed for patients who dropped out to check symptom changes. The recalculated estimated responder rate included the telephone survey results.Results: The 12-month follow-up was completed with 154 knees (68%), whereas 74 knees dropped out. The follow-up rate was significantly lower in KL4 than KL2 and 3. The KOOS significantly improved in 154 knees, whereas the KOOS was lower in KL4 than in KL2. The responder rate was 56% total, 58% in KL2, 56% in KL3, and 51% in KL4; however, the estimated responder rate, including the telephone survey, was 48% total, 54% in KL2, 50% in KL3, and 39% in KL4.Conclusion: This study showed improved clinical symptoms 1-year after APS injections for KOA, with a lower responder rate in KL4 than in KL2 or KL3.
Analysis of the characteristics associated with hepatitis C virus infection in hospitals featuring infectious diseases: A retrospective study
Authors: Han Ying , Yin Shangqi , Zheng Mei , Meng Huan , He Chaonan , Han Jinyu , Chen Jin , Wang Yajie
Published: June 2022

Background: The hepatitis C virus infection is a high-risk factor for cirrhosis or hepatocellular carcinoma. However, since the majority of hepatitis C patients are asymptomatic or mildly symptomatic, they remain undetected with no timely treatment. In this study, we collected the data of patients positive for HCV antibodies and HCV-RNA from our hospital and analyzed the status and characteristics of hepatitis C virus infection in a hospital featuring infectious diseases.Methods: Data were obtained from patients admitted to Beijing Ditan Hospital between 2017 and 2020. The HCV antibodies and HCV-RNA positivity rates were compared among different age groups along with the age distribution of positive patients. In addition, HCV antibodies and HCV-RNA positivity rates, as well as inpatients HCV antibody detection rate, were analyzed between 2017 and 2020. Results: The average positivity rate (%) of HCV antibody was 6.78%, with the highest rate in the 50-59 age group. Whereas, the average positivity rate (%) of HCV-RNA testing was 24.08%, which showed a continuous increase with an increase in age. Patients aged 50–59 years comprised the highest number of patients with both HCV antibodies and HCV-RNA positivity. Women had a higher positivity rate of HCV antibodies than men (P<0.001). Between 2017 and 2020, the positivity rate (%) of HCV antibodies showed a continuous decrease from 7.6% to 6.24% (P<0.0001). Contrastingly, the positivity rate (%) of HCV-RNA showed a continuous increase from 22.03% to 26.58% (P = 0.0004). The detection rate of HCV antibodies in inpatients was 59.8%, while the positivity rate was 5.24%. While the detection rate showed an upward trend, the positivity rate showed a downward trend.Conclusions: Our hospital displayed a clustering effect on HCV-infected patients as well as on the high-risk group of people. Hence, there was a need to strengthen the awareness in patients for active screening of hepatitis C, especially in patients over 40 years of age. The population with age 50–59 was more susceptible to HCV infection and required more attention to hepatitis C screening. Furthermore, inpatient detection results should be completely used to ensure more visibility and on-time treatment of patients.
Isolation, diversity, and the evaluation of multi-trait plant growth promoting rhizobacteria associated to roots of saffron (Crocus sativus L.)
Authors: Chamkhi Imane , Laila Sbabou , Jamal Aurag
Published: June 2022

The cultivation of Crocus sativus L. (saffron) is of particular interest in view of the sale of this spice on the world market. It is a very popular product throughout the world, especially for its culinary and medicinal virtues. In order to maintain the quality of the product, the organic production method without chemical inputs should be maintained and improved by the application of organic fertilizers and biofertilizers based on beneficial micro-organisms such as plant growth-promoting rhizobacteria (PGPR), which are capable of boosting the productivity. In this context, a better knowledge of the microbial populations of the rhizosphere of saffron is needed. The isolation of rhizobacterial strains was carried out from saffron soil collected from Taliouine-Talakhat region (Morocco). Plant growth promoting traits (PGP) activities of these isolates were evaluated by measuring, auxin production, siderophore production, phosphate solubilization, biological nitrogen fixation, aminocyclopropane -1-carboxylate (ACC) deaminase activity, cellulose activity, and antagonistic activity. Moreover, molecular identification of the isolates was determined by using 16S rDNA gene sequencing. Results showed that a collection of 88 bacteria strains were isolated from rhizospheric soils. The evaluation of PGP of these isolates showed that most of them possessed one or more PGP activity studied. The molecular identification of the isolates by 16S rDNA gene sequencing revealed eight genera: Pseudomonas, Rahnella, Variovorax, Delftia, Bacillus, Rhizobium, Luteibacter, and Pantoea, while, Pseudomonas was the most abundant genus. The findings of this study suggest that the isolates with higher levels of PGP activities can be used for the conception of bacterial biofertilizers that will be applied in saffron field inoculation trials.
Water vapor fuelled brine-silk cocoon protein bio-battery for a self-lighting kettle and water-vapor panels
Authors: Jangir Himanshi , Das Mainak
Published: June 2022

Water vapor increases the electrical conductivity of silk cocoons, human hair, jute, and corn silk. This phenomenon is unclear. In the present study, XPS analysis of cocoons showed that water vapor reduces the surface presence of low-energy carbon species (C-C, C-H). In contrast, electron-dense, high-energy carbon species (C-N, C = C, C = O) remained unchanged, possibly enhancing surface charge hopping. While water vapor improves the conduction, the deficiency of charge carrier diminishes the effect. We increase the charge carrier by soaking the cocoon in an aqueous solution of common salt (NaCl) to amplify the current. Salt treatment followed by two-minute exposure to water vapor results in a sharp upward spike in the current (3.6 ± 1.07 mA, n = 12; mean ± SE) from the baseline (0.06 ± 0.02 mA, n = 12). After one hour, it maintains an average value of 0.39 ± 0.12, n = 12) ampere, indicating an upward shift in the baseline. Every time the cocoon charges with water vapor, the next charging cycle initiates after the cocoon dries up. Inspired by the cocoon ecology, we demonstrate an alternating 'water vapor- dry air' cycle for rapid charging and discharging of the cocoon battery. Finally, we designed a prototype of a self-lighting kettle and water-vapor panels for futuristic homes using a 'brine-silk cocoon protein bio-battery,' where moist waste heat generates electricity.
Mail-based harm reduction services are key solutions to reduce the impact of COVID-19-like crises on people who use drugs: evidence from two independent structures in France and in the USA
Authors: Torres-Leguizamon Magally , Favaro Jamie , Coello Dan , Reynaud Emmanuel G. , Néfau Thomas , Duplessy Catherine
Published: June 2022

Background: Harm Reduction (HR) policies for People Who Use Drugs (PWUD) have a significant positive impact on their health. Such approaches limit the spread of infections and reduce opioid overdose mortality. These policies have led to the opening of specialized centers located mainly in big cities and urbanized zones. The COVID-19 pandemic reduced access to HR centers in locations undergoing lockdown. Before the pandemic, HR services in France and in the USA were complemented by the development of remote HR programs: HaRePo (Harm Reduction by Post) for France, implemented in 2011, and NEXT Distro for the USA founded in 2017. These programs are free and specifically designed for people who have difficulties accessing HR tools and counseling in-person. PWUD can access HaRePo program by phone and/or email. NEXT Distro users can access the program through its dedicated website. The COVID-19 pandemic and the associated lockdowns have drastically impacted the HR services in both countries and many HR centers were forced to adapt their activities. Methods: Here, we analyzed how lockdowns impacted the number of new users entering the programs, the numbers of parcels sent and naloxone distributed using the records of both structures. With the ability to reach PWUD remotely, HaRePo and NEXT Distro were particularly effective at maintaining service continuity and scaling up services to meet the needs of PWUD during the COVID-19 pandemic.Results: By comparing previous year’s data average with a 95% confidence interval, we showed that the activity of both programs were significantly impacted by the pandemic. Both show an increase in new users joining the programs as well as the number of parcels sent per month. It shows that remote HR was able to partially compensate for the reduced HR activities due to COVID-19. We also observed that the distribution of naloxone per parcel tends to increase for both structures. Conclusion: By studying two independent structures in France and in the USA sharing similar objectives (remote HR), we showed that this approach can be a key solution to crises that impact classical HR structures despite various differences in operating procedures between countries.
Potential biomarker proteins for aspiration pneumonia detected by shotgun proteomics using buccal mucosa samples: A cross-sectional study
Authors: Ogura Kohei , Endo Maho , Hase Takashi , Negami Hitomi , Tsuchiya Kohsuke , Suzuki Takeshi , Ogai Kazuhiro , Sanada Hiromi , Okamoto Shigefumi , Sugama Junko
Published: June 2022

Background: Aspiration pneumonia (AP), which is a major cause of death in the elderly, does present with typical symptoms in the early stages of onset, thus it is difficult to detect and treat at an early stage. In this study, we identified biomarkers that are useful for the detection of AP and focused on salivary proteins, which may be collected non-invasively. This is because expectorating saliva is often difficult for elderly people, so we collected salivary proteins from the buccal mucosa.Methods: We collected samples from the buccal mucosa of six patients with AP and six control patients (no AP) in an acute-care hospital. Following protein precipitation using trichloroacetic acid and washing with acetone, the samples were analyzed by liquid chromatography and tandem mass spectrometry (LC-MS/MS). We also determined the number of cytokines and chemokines in non-precipitated samples from buccal mucosa.Results: Comparative quantitative analysis of LC-MS/MS spectra revealed 179 and 181 proteins that were significantly higher and lower in abundance, respectively, in the AP group compared with the control group. We identified eight proteins (chloride intracellular channel protein 3, b-defensin 4A, protein S100-A7A, Purkinje cell protein 4-like protein 1, glutamine synthetase, protein S100-A7, cytosolic 5'-nucleotidase 3A, pyridoxal kinase) that were detected in all of the AP samples with high coverage, indicating that these proteins are promising AP biomarker candidates. In addition, the abundance of C-reactive protein (CRP) in oral samples was highly correlated with serum CRP levels, suggesting that oral CRP levels may be used as a surrogate to predict serum CRP in AP patients. A multiplex cytokine/chemokine assay revealed that MCP-1 tended to be low, indicating unresponsiveness of MCP-1 and its downstream immune pathways in AP.Conclusion: Our findings suggest that oral salivary proteins, which are obtained non-invasively, can be utilized for the detection of AP.
Clinical value and potential mechanisms of BUB1B up-regulation in nasopharyngeal carcinoma
Authors: Qin Li-Ting , Huang Si-Wei , Huang Zhi-Guang , Dang Yi-Wu , Fang Ye-Ying , He Juan , Niu Yi-Tong , Lin Cai-Xing , Wu Ji-Yun , Wei Zhu-Xin
Published: June 2022

Nasopharyngeal carcinoma (NPC) has insidious onset, late clinical diagnosis and high recurrence rate, which leads to poor quality of patient life. Therefore, it is necessary to further explore the pathogenesis and therapy targets of NPC. BUB1 mitotic checkpoint serine/threonine kinase B (BUB1B) was found to be up-regulated in a variety of cancers, but only one previous study showed that BUB1B was overexpressed in NPC and the sample size was small. The clinical role of BUB1B expression and its underlying mechanism in NPC require more in-depth research. Immunohistochemical samples and public RNA-seq data indicated that BUB1B protein and mRNA expression levels were up-regulated in NPC, and summary receiver operating characteristic curve indicated that BUB1B expression level had a strong ability to distinguish NPC tissues from non-NPC tissues. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes were performed and revealed that BUB1B and its related genes were mainly involved in cell cycle and DNA replication. Protein- Protein Interaction were built to interpret the BUB1B molecular mechanism. Histone deacetylase 2 (HDAC2) could be the upstream transcription factor of BUB1B, which was verified by Chromatin Immunoprecipitation Sequencing samples. In summary, BUB1B was highly expressed in NPC, and the predicted BUB1B upstream transcription factor HDAC2 may affect cell cycle by regulating BUB1B to promote cancer progression.
Secondary Budd-Chiari syndrome occurred after adjuvant radiotherapy for perihilar cholangiocarcinoma: A case report
Authors: Miura Yuya , Ashida Ryo , Saiga Atsushi , Sugiura Teiichi , Ohgi Katsuhisa , Yamada Mihoko , Otsuka Shimpei , Aramaki Takeshi , Sato Rui , Uesaka Katsuhiko
Published: June 2022

Background: Budd–Chiari syndrome (BCS) is a rare vascular disorder of the liver, and acute and secondary BCS is even rarer. Case presentation: A 62-year-old man with perihilar cholangiocarcinoma of Bismuth type IIIa underwent right hemi-hepatectomy with caudate lobectomy and pancreatoduodenectomy. Adjuvant chemoradiotherapy was performed due to a positive hepatic ductal margin. Subsequently, the disease passed without recurrence. The patient visited for acute onset abdominal pain at the 32nd postoperative month. Multidetector-row computed tomography (MDCT) showed stenosis of the left hepatic vein (LHV) root, which was the irradiated field, and thrombotic occlusion of the LHV. The patient was diagnosed with acute BCS caused by adjuvant radiotherapy. Although anticoagulation therapy was performed, the patient complained of sudden upper abdominal pain again. MDCT showed an enlarged LHV thrombus and hepatomegaly. The patient was diagnosed with exacerbated acute BCS, and stenting for the stenotic LHV root was performed with a bare stent. Although stenting for the LHV root was very effective, restenosis occurred twice due to thrombus in the existing stent, so re-stenting was performed twice. The subsequent clinical course was acceptable without recurrence or restenosis of the LHV root as of six months after the last stenting using a stent graft.Conclusion: Although no case of BCS caused by radiotherapy has yet been reported, the present case showed that late side effect of radiotherapy can cause hepatic vein stenosis and secondary BCS.
The Role of Green Gram Plant Volatile Blends in the Behavior of Arctiid Moth, Spilosoma Obliqua
Authors: Mobarak Syed Husne , Koner Anamika , Debnath Rahul , Barik Anandamay
Published: June 2022

Larvae of Spilosoma obliqua Walker (Lepidoptera: Arctiidae) feed on the leaves and flowers of green gram [Vigna radiata (L.) Wilczek] and reduce seed yield. Therefore, it is interesting to observe whether undamaged (UD) and insect-damaged (ID, plants after feeding by S. obliqua larvae) plants cause attraction of conspecific adult moths. Females showed attraction towards volatile blends of UD, ID and mechanically-damaged (MD) plants of three green gram cultivars [PDM 54 (PDM), Pusa Baisakhi (PUSA) and Samrat (SAM)] in Y-tube olfactometer bioassays. Females were more attracted towards volatile blends of ID plants of a particular cultivar than UD plants of the same cultivar. Total amount of volatiles was higher in ID plants than UD plants. Some herbivore-induced plant volatiles − 3Z-hexenal, 1-hexanol, 3Z-hexenyl acetate, 2-octanol and ocimene were attractive to the insect. Females were attracted towards three synthetic blends (µg in 25 µl CH2Cl2) comprised − 2.97 µg 3Z-hexenal, 4.92 µg 1-hexanol, 5.56 µg benzaldehyde, 9.76 µg 3Z-hexenyl acetate, 7.27 µg 2-octanol, 7.97 µg ocimene and 5.71 µg acetophenone resembling PDM, 4.68 µg 3Z-hexenal, 8.38 µg benzaldehyde, 7.66 µg 3Z-hexenyl acetate, 5.96 µg ocimene and 7.60 µg acetophenone resembling PUSA, and 3.39 µg 3Z-hexenal, 6.29 µg benzaldehyde, 8.74 µg 3Z-hexenyl acetate, 6.17 µg ocimene and 3.69 µg acetophenone resembling SAM in olfactometer and wind tunnel bioassays. Females could not distinguish between these three synthetic blends in olfactometer and wind tunnel bioassays, suggesting that these three synthetic blends could be used as lures in developing baited traps in integrated pest management strategies.
From marginal zone lymphoma to aggressive diffuse large B-cell lymphoma: a whole-exome and clinicopathological characteristics analysis of transformed lymphoma
Authors: Zhao Xia , Bian Haiyan , Hao Fengyun , Shao Shihong , Wu Chuanhong , Zhang Qian , Zhao Xiangzhong , Wu Mingxuan , Li Zhiqiang , Gao Chengwen
Published: June 2022

Transformed lymphoma occurs when indolent lymphoma transforms into more aggressive lymphoma and are associated with poor prognosis. In this study, we analyzed the immunophenotypes, prognostic factors, and outcomes of 35 patients with transformed lymphoma from among 306 marginal zone lymphoma (MZL), 544 follicular lymphoma (FL), and 871 chronic lymphocytic leukaemia/small lymphocytic lymphoma (CLL/SLL) cases. In addition, we performed whole-exome sequencing study of 7 transformed MZL (tMZL) cases. Our results demonstrate that the median time from indolent lymphoma diagnosis to transformed DLBCL was 35 months (range, 14–53 months). The 5-year overall survival (OS) and progression-free survival (PFS) rates after histological transformation (HT) were 50% and 26%, respectively. Kaplan-Meier survival analysis revealed that asynchronous HT and transformed CLL/SLL (tCLL/SLL) were significant adverse prognostic factors for OS after DLBCL HT. Our study found that TNFAIP3 was the most frequently mutated gene in tMZL samples. We identified mutations involvement in chromatin remodeling (CREBBP and EP300) and regulators of NF-κB signaling (TNFAIP3, BCL10, MYD88, CD79B, and CARD11) were affected in tMZL. Whole-exome sequencing and copy-number analysis revealed that tMZL derives from the divergent evolution of an ancestral common progenitor clone (CPC). Collectively, this study provides clinicopathological characteristics of three common types of transformed lymphomas and the genetic profile of tMZL with diagnostic and therapeutic implications.
The origin for the increased Curie temperature of B20-MnSi films
Authors: Li Zichao , Yuan Ye , Begeza Viktor , Rebohle Lars , Helm Manfred , Nielsch Kornelius , Prucnal Slawomir , Zhou Shengqiang
Published: June 2022

B20-type MnSi is the prototype magnetic skyrmion material. Thin films of MnSi show a higher Curie temperature than their bulk counterpart. However, it is not yet clear what mechanism leads to the increase of the Curie temperature. In this work, we grow MnSi films on Si(100) and Si(111) substrates with a broad variation in their structures. By controlling the Mn thickness and annealing parameters, the pure MnSi phase of polycrystalline and textured nature as well as the mixed phase of MnSi and MnSi1.7 are obtained. Surprisingly, all these MnSi films show an increased Curie temperature of up to around 43 K. The Curie temperature is likely independent of the structural parameters within our accessibility including the film thickness above a threshold, strain, cell volume and the mixture with MnSi1.7. However, a pronounced phonon softening is observed for all samples, which can tentatively be attributed to slight Mn excess from stoichiometry, leading to the increased Curie temperature.
C-type lectin domain family 4 member G(CLEC4G) is a negative marker for CD34 in the evolution of liver pathogenesis
Authors: Chen Xiang , Jiang Zui-ming , Gu Min , Feng Bin , Xie Zhi-qin , Huang Mei-yuan , Chen Zhu , Tang Man-ling
Published: June 2022

Purpose: This study aimed to explore the expression of the C-type lectin domain family 4 member G (CLEC4G) gene in the liver sinusoidal endothelial cells (LSECs) during liver pathogenesis, and to evaluate its correlation with CD34 and clinical significance in hepatocellular carcinoma patients. Methods: We conducted bioinformatics analysis of the differential expression of CLEC4G in in various human organs, carcinomatous and adjacent tissues. Then, the differential expression in carcinomatous and adjacent tissues was verified by real-time quantitative reverse transcription PCR (qRT-PCR) and immunohistochemical (IHC) analyses in clinical HCC samples. The expression of CLEC4G in normal liver tissues and cirrhotic tissues was further detected. Besides, mRNA and protein expression levels of CD34 in HCC samples were detected via qRT-PCR and IHC, respectively. ELISA was applied to detect serum levels of CLEC4G in healthy controls, liver fibrosis and HCC patients. The correlation between the CLEC4G and CD34 expression was analyzed using the Spearman test, whereas the Chi-square test was applied to analyze the correlation between CLEC4G and clinicopathological characteristics of HCC patients. Furthermore, the Kaplan-Meier method was used to estimate the relationship between CLEC4G serum levels and survival. Results: The expressions of mRNA and protein levels of CLEC4G were higher in normal liver tissues, moderately expressed in cirrhotic and para-cancerous tissues (P<0.001), and lowest in HCC tissues (P<0.001). We also found high CD34 expression in late tumors, which was negatively correlated with CLEC4G at both mRNA and protein levels (R=-0.830, P<0.001; R=-0.817, P<0.001, respectively). Compared to the healthy controls, the CLEC4G levels in liver fibrosis patients, and HCC patients were gradually lower (P<0.001). Furthermore, CLEC4G was highly associated with tumor size (P=0.023), tumor stage (P=0.046), and vascular metastasis (P=0.008; Table 1) in HCC patients. Notably, HCC patients expressing low CLEC4G levels were characterized by a shorter survival time (P=0.032). Conclusions: The low expression of CLEC4G is potentially correlated with LSEC capillarization and the appearance of micro-vessels. Such a phenomenon may exert an endogenous protective effect against the progression of liver disease and serve as a reliable diagnostic marker for hepatocellular carcinoma.
Tansmembrane TNF-α as a novel biomarker for the diagnosis of cytokine storm in a mouse model of multiple organ failure
Authors: yang peng , Zeng Yimin , Yang Fang , peng xin , Hu Yongsheng , Tan Xuhong , Zhang Ruping
Published: June 2022

A cytokine storm(CS) is an out-of-control inflammatory response closely associated with the progression of diseases, such as multiple organ failure(MOF), severe sepsis, and severe or critical COVID-19. However, there is currently a lack of reliable diagnostic markers to distinguish CS from normal inflammatory responses. Tumor necrosis factor-α (TNF-α) includes transmembrane TNF-α (tmTNF-α) and secreted TNF-α (sTNF-α). The MOF mouse model in this study showed that the tmTNF-α expression changes in the neutrophils differed from the serum TNF-α and serum IL-4, IL-6, IL-10, and IL-18 and it was the tmTNF-α, instead of serum TNF-α, IL-4, IL-6, IL-10, and IL-18, that reflected the liver and kidney tissue damage and increased with the aggravation of these injuries. Analysis of the ROC results showed that tmTNF-α effectively distinguished between inflammatory response and CS and efficiently differentiated between surviving and dead mice. It also significantly improved the diagnostic value of the traditional CRP marker for CS. These results indicated that tmTNF-α expressed in the neutrophil could be used to diagnose CS in MOF mice, providing an experimental basis to further develop tmTNF-α for diagnosing CS patients.
Rapid Malignant Transformation of Adrenal Cortical Adenoma: A Case Report and Review of the Literature
Authors: Cao Zhenzhen , Deng Qian , Cui Mengying , Ge Kele , Wu Chen , Wu Jun , Wu Changping
Published: June 2022

With the development of science and technology, adrenal incidentaloma (AI) is more and more recognized, and adrenal cortical carcinoma (ACC) is an extremely rare and aggressive cancer of the adrenal gland. According to the report, the risk of malignancy was 0.1% in ACC species with benign initial Computed tomography (CT) features. And, in most cases, a transition period of seven to 10 years is required. In 2018, a patient with an AI was admitted to our hospital. The pathological diagnosis of the operative specimen was adrenal cortical adenoma (ACA). Two years after the surgery, the patient was admitted to our hospital again with abdominal pain and neck pain. CT scan revealed a large retroperitoneal mass with intratumor hemorrhage. Subsequent positron emission tomography (PET) revealed multiple metastases to the liver and bone. The pathological diagnosis of liver and retroperitoneal metastatic lesions was an adrenal cortical tumor (ACT). Given the biological behavior and imaging results of the malignant invasion of the patient's tumor, we finally diagnosed ACC. In this case report, we discuss the cause and possibility of the patient's rapid transition from ACA to ACC in less than two years and review the literature.
Electronic Cigarette Portrayal in Indonesia: A Content Analysis of News Media
Authors: Bigwanto Mouhamad , Arumsari Imas , Fauzi Ridhwan
Published: June 2022

Background: The news media play an essential role in shaping public opinion. Analyzing a specific issue reported in the news media provide insight and considerations for a government to form a policy. The study aimed to assess the portrayal of the electronic cigarette issue in Indonesian news media, including the variety of arguments being presented and the actors behind it.Methods: We used a paid service database from eBdesk to collect the Indonesian news articles from 2020 to 2021 using the keywords; 'rokok elektronik', 'rokok elektrik', 'e-rokok', 'vape' and 'vaping'. Content analysis of 551 full-text news articles was conducted to identify the concepts, topics, and frames of quoted arguments and to examine whether any frames were presented on the different types of organizations and the origin of actors. Results: News articles related to e-cigarettes were mostly published in the national newspaper and in the non-health section at the newspaper desk. A total of 891 arguments from 393 persons representing 212 institutions were identified. Twenty-eight concepts were further categorized into 12 topics. Health impact was the most frequently reported topic, followed by regulation, tax/price issues, and e-cigarettes as smoking cessation tools. Overall, the articles and arguments with positive tones toward e-cigarettes outnumbered negative articles and arguments. The industry, university and research-based institutions were the most involved type of organizations in the news articles report. There were more equal frames toward e-cigarettes among the international actors and government, even though the frame within the non-health government sector was reported to be more positive towards e-cigarettes.Conclusions: Although health impact is the most reported topic, the actors involved in delivering arguments were mainly from the non-health sector, including where the news articles were published on the newspaper desk. The E-cigarettes issue in Indonesia was mainly played by the non-health sector, which is more inclined toward economic interest than health.
Hydrogel Conductivity Impacts Skin Dose from Tumor Treating Fields
Authors: Lok Edwin , Liang Olivia , Clark Matthew , Malik Talbia , Wong Eric T
Published: June 2022

Purpose: Tumor Treating Fields (TTFields) disrupt tumor cells while they are undergoing mitosis. In patients, transducer arrays are applied to scalp or body surface for treatment of glioblastomas, mesothelioma, or other systemic malignancies. Dermatologic complications are thought to be related to hydrogel, which is applied between the electrodes and scalp or skin surface to facilitate electric field penetration. But the high intensity of TTFields on these surfaces may also be a contributing factor.Methods and Materials: Magnetic resonance imaging data sets from 7 glioblastoma patients and attenuation-corrected positron emission tomography–computed tomography data sets from 3 non-small cell lung carcinoma and 2 ovarian carcinoma patients were used to fully segment various anatomic structures. A 3-dimensional finite element mesh model was generated and then solved for the distribution of applied electric fields, rate of energy deposition, and current density at the gross tumor volumes (GTVs) and clinical target volumes (CTVs). Electric field-volume histograms, specific absorption rate–volume histograms, and current density-volume histograms were generated, by which plan quality metrics were used to evaluate relative differences in field coverage between models at various hydrogel conductivities.Results: TTFields coverage at the GTV or CTV increased up to 0.5 S/m for head and 1.0 S/m for thorax and pelvis models, and no additional increase was observed after these saturation points. The scalp and skin hotspots also increased accordingly. Although the scalp hotspots increased by +4.2%, +7.5%, and +3.2% in E5%, SAR5%, and CD5%, the skin hotspots increased by as much as +21.7%, +51.3%, and +41.0%, respectively.Conclusion: TTFields delivery for the treatment of cancer can be modulated by the conductivity of the hydrogel at the transducer-scalp or transducer-skin interface. Optimizing this aspect of TTFields delivery may increase tumor control while minimizing toxicity at the scalp or skin.
Existence and Hyers-Ulam stability results for abstract equations in Banach lattices and application
Authors: Benkaci-Ali Nadir
Published: June 2022

In this paper, we are interested in the existence and Hyers-Ulam stability for the abstract equation in Banach lattices and application. In the application, we transform the given fractional differential system of (p₁,p₂,...,pn)-Laplacian Hilfer equations into an equivalent integral equation. Then we establish sufficient conditions and employ the fixed point index arguments and spectral theory to obtain new results on the existence and Hyers-Uulam stability. Examples illustrating the main theoritical results are also constructed. This work contains several new ideas, and gives a unified approach applicable to many types of initial value systems involving (p₁,p₂,...,pn)-Laplacian type operators
Cuproptosis-related genes signature is associated with tumor progression, PD-L1 stability and bystander T cells in esophageal carcinoma
Authors: Sun Qiang , Jiang Runmin , Huan Yu , Li Yan , Zhang Feng , Jiang Tao , Gao Xinyue
Published: June 2022

Esophageal carcinoma (ESCA) is a common type of cancer with high mortality. Cuproptosis is a new type of cell death and characterized by the dependence on mitochondrial respiration and protein lipoylation. However, the potential roles of cuproptosis-related genes (CRGs) in ESCA remains elusive. Here, we systematically assessed the transcriptional and genetic alterations of cuproptosis-related genes (CRGs) in ESCA. We identified a cuproptosis-related genes (CRGs) signature for ESCA patients. A 6-CRGs signature was constructed by Least absolute shrinkage and selection operator (LASSO) regression analysis along with the univariate cox regression analysis and differential genes analysis. The CRGs score could significantly stratify ESCA patients’ survival and high CRGs score was significantly correlated with bad overall survival. Moreover, higher CRGs score indicated higher pathology grades and aberrant cell adhesion, possibly via the PI3K-AKT pathway, which could also underly their more sensitivity to PI3K-AKT pathway inhibitors as well. In addition, patients with high CRGs were tend to hold more mutation loading and abnormal APOBEC mutation. Notably, higher CRGs score was anomalously associated with more immune infiltration, while could explain its malignancy by more PD-L1 stability and more proportion of bystander T cells. In conclusion, our report revealed the significance of cuproptosis in ESCA and held a potential therapeutic promise of activating the bystander T cells.
Angiotensin II-pretreated hucMSCs attenuate inflammation and reverse pulmonary fibrosis in SD rat lung
Authors: wang wei , Song Aishi , Deng Weiyue , Zhang Yuying , Mukama Omar , Habimana Jean de Dieu , Xie Wei , Zhou Peng , Li AmyL , Li Jiaxing , Deng Sihao , Ni Bin , Peng Kexin , Zhang Shusheng , Yan Xiaoxin , Huang Jufang , Li Zhiyuan
Published: June 2022

Background
Pulmonary fibrosis (PF) is an irreversible disease with a poor prognosis and a serious impact on patients' health. PF is also associated with COVID-19, especially in immunocompromised people. Herein, efforts have been made to treat PF using pretreatment of human umbilical cord mesenchymal stem cells (hucMSCs) with angiotensin II (Ang II) as a novel therapeutic method.
Results
Our results first showed that Ang II pretreatment induced more hucMSCs to reach the injured lung and alleviated pulmonary fibrosis. Transplantation of hucMSCs-Ang II reduced inflammatory infiltration, increased IL-10 expression and enhanced macrophage matrix-metallopeptidase-9 (MMP-9) expression for collagen degradation. Moreover, the Ang II-treated hucMSCs decreased hydroxyproline (HYP) and alpha-smooth muscle actin (α-SMA) expression in SD rats and promoted collagen and collagen fiber degradation.
Conclusions
Ang II pretreatment enhanced the homing ability of hucMSCs, and hucMSCs-Ang II transplantation reversed PF by inhibiting inflammation and promoting collagen and collagen fiber degradation, promising its clinical application in the treatment of post-inflammatory PF caused by various disorders, including COVID-19 and related pneumonia.
Bilateral and symmetrical accessory digastric muscles
Authors: Li Zhikai , Shen Xinhua , Wang Naili , Ma Chao
Published: June 2022

During dissection of the suprahyoid region, a pair of big bilaterally symmetrical anomalous accessory digastric muscles were discovered, which lay superficial to the mylohyoid muscle and occupied nearly all the area between the anterior bellies of digastric muscle. The bilateral anomalous muscles formed a trapezoid. Its base connected the left and right intermediate tendons of digastric muscle and free from the hyoid bone. The lower portion was thick and the muscle fibers ran horizontally. The upper portion became thin while running medially and superiorly, and eventually formed an aponeurosis attached to the lower margin of the mandible between the digastric fossae. In the midline, the bilateral muscle fibers crossed each other and fused deeply with the mylohyoid raphe. In addition, the intermediate tendon of digastric muscle didn’t pass through the stylohyoid muscle and had no fibrous sling on both sides, whereas it crossed over and lay superior and lateral to the stylohyoid muscle. No other morphologic abnormalities were found in this region. This unique coexisted variation of anterior bellies and intermediate tendons has not been previously reported in the literature. It is important to be familiar with the digastric variations both in anatomy teaching and in clinic practice.
Arsenic Hazard Mapping of Ranchi City using QGIS
Authors: Ballabh Varad , Mahto Rupesh , Kumar Diwesh
Published: June 2022

Water used for the drinking purpose should be free from any contamination like Arsenic, Nitrite, Iron etc. Arsenic is one of the most hazardous substances found in underground water. It is very difficult to detect the presence of Arsenic in the groundwater and a lot of research is going on in this regard. Ranchi is capital of Jharkhand state situated at 23.36-degree North to 85.33-degree East. Tropic of Cancer is passing through the city at 23.4-degree North. Ranchi city has a population of about 1.073 million as per 2011 census. This paper presents the arsenic mapping of the Ranchi city. With the help of multivariate interpolation it is found that the maximum value of Arsenic is 212.998 microgram per liter near Tunki Tola. The minimum value of Arsenic is below desired level (BDL) at Sidhu Kanhu Park. This result can be used to aware the people to stop using or installing any new borewell in the Arsenic affected area.
Error Estimates of Hermite-Hadamard type Inequalities on Quantum Calculus
Authors: Samraiz Muhammad , Saeed Kanwal , Naheed Saima , Nonlaopon Kamsing
Published: June 2022

In this paper, we establish error estimates of Hermite-Hadamard inequalities corresponding $_{\zeta_{1}}q$-fractional calculus operators via (α,m)$-convex functions. Identity is used to examine the main results of this study. The results in the literature are obtained as remarks on our general consequences.
Morphological characteristics and changes in the Upper Reach Gumara River in Ethiopia from 1957 to 2020
Authors: Melsse Dessie Wubetu , Tegegne Moges Animut , Zewudu Getanew Sewunetu , Mebre Daniel wondie
Published: June 2022

Human intervention with the natural landscape, including various river systems, is increasing in most parts of our country due to population growth and their infinite demand. As a result of this, the river system was jeopardized, causing irreversible damage to the socioeconomic and infrastructural systems. Morphological characterization and change evaluation of rivers are essential prerequisites for investigating their historical evolution and making reasonable estimates about how rivers might adapt to changing natural conditions and increasing anthropogenic impacts. This study focuses on the upper reach of the Gumara River along a 47.336 km stretch because it is a highly meandering and dynamic fluvial system with minor natural and anthropogenic influences that harm living and nonliving things around the flow path. We use satellite images as a data source, and the study reach was divided into six sections based on the waterway geometry and various forms of human intervention along the river, for detailed river morphological characterization and change detection, and to know the disturbance that facilitates the change in sub reach. In addition to satellite imagery, field observations, informal interviews with local indigenous people, laboratory analysis of bank material, and Meteorological and Hydrological data were used. The primary goal of this study was to assess the Morphological Characteristics and Change of the Upper Reach Gumara River over a 64-year period in Tana Basin, Ethiopia. Image analysis software (ERDAS Imagine 2015 and Arc GIS 10.5) was used for data preparation and analysis, and to characterize and detect the change of study reach, various morphometric parameters such as Sinuosity index, braided index, River center line, actual River length, river width, meander neck length, and River area were determined. From the entire period of 64 years of sinuosity index analysis, the sinuosity was increased by 5.49%. The section between five and six had a 63% reduction in neck length. Over a 64-year period, the overall width increased by 0.348 m per year. All of the morphometric parameter results and social information show that the upper reach of the Gumara River was dynamically changed and disrupted the surrounding socioeconomic system, implying that critical measurements should be designed and implemented.