bluuebunny/crossref_metadata_2025 huggingface dataset:
Medical School Curriculum And The Level Of Compassion Of Portuguese Medical Students
Authors: Santiago Luiz Miguel , Batptista Ana Teresa Sá Cachada , Maurício Katia , Siytangco-Johnson Sean
Published: March 2020

Objectives To evaluate and to compare the levels of compassion of students throughout the Integrated Master’s in Medicine (MIM) in Portuguese Universities and relating them to University’s formal curriculum.Methods Cross sectional study of the levels of compassion of 1st, 3rd and 5th year students (3rd, 4th and 5th years in the University of XX) by electronically appliance of the Jefferson Scale of Medical Empathy (student version), between October and November 2018. Curricular plans of each University was searched on the institutional sites. The percentages of Credit Units (CU) and EUROPEAN CREDIT TRANSFER SYSTEM (ECTS) were calculated for the concept and/ or pillars of compassion. Adequate descriptive and inferential statistics were defined with difference definition for p <0.03.Results Mean levels of compassion are numerically far from their maximum value (49), being different between sexes p<0.001, year of attendance, p=0.022 and university, p=0.026). The percentage of CU related to the compassionate approach is significantly different between faculties (p <0.001), but the percentage of ECTS is not different (p = 0.031).Discussion This is the first comparative study between Portuguese medical schools. The reduction in the levels ​​of compassion of future physicians is a matter of concern for medicine schools.Conclusion There are differences in the levels of compassion among the students of the var universities according to the year attended. There are no differences between the percentage values ​​of ECTS, according to the institutional websites. The measured value is generally favourable to student´s Compassion. Differences between Universities deserves future studies.
ESTUDO DA REMOÇÃO DE NITRATO EM FASE AQUOSA UTILIZANDO ARGILA MONTMORILONITA E SÍLICA GEL MODIFICADA
Authors: Buarque Patrícia Marques Carneiro , Silva Eduarda Maria Farias , Lucena Karyna Oliveira Chaves de , Oliveira Mayara de Sousa , Domingos Gleiciely Lima , Alexandre Jéssica Beserra , Ferreira Célia Cristina Moraes
Published: March 2020

Atividades humanas como a disposição inadequada de resíduos líquidos e sólidos, uso desenfreado de fertilizantes e a utilização de combustíveis fósseis, tem promovido alterações no ciclo natural do nitrogênio. A presença desse composto nos seus diferentes estados de oxidação é indicativo de contaminação em corpos hídricos e de possíveis condições sanitárias insatisfatórias. Assim, este estudo avaliou o uso potencial de uma nanoargila montmorilonita modificada com aminopropiltrietoxisilano e octadecilamino e de uma sílica gel modificada com 3-aminopropiltrietoxisilano como adsorventes para a remoção do ânion nitrato a partir de soluções aquosas sintéticas. Para isso, utilizou-se soluções sintéticas contendo 20 mg/L de nitrogênio na forma de nitrato (NO3- -N), a fim de comparar as porcentagens de remoção obtida com os materiais em estudo. A caracterização do melhor adsorvente foi realizada utilizando uma estimativa da carga da superfície do material, o Ponto de Carga Zero (PZC), com faixa de pH variando entre 1 e 12. Foram realizados ensaios para avaliar o efeito da dosagem do adsorvente (com massas de 50, 100, 150, 200, 250 e 300 mg) e efeito do pH (2, 4, 6, 8 e 10). Os resultados revelaram que a argila obteve maior eficiência de remoção. O pH ácido foi o mais favorável para a adsorção de nitrato na argila aminofuncionalizada. As remoções da nanoargila selecionada chegaram a aproximadamente 70% em determinadas condições experimentais, dessa forma é possível constatar que argilas aminofuncionalizadas podem ser utilizadas como adsorventes na remoção de nitrato de águas.
ADEQUAÇÃO DE SERVIÇOS DE ALIMENTAÇÃO ÀS BOAS PRÁTICAS DE FABRICAÇÃO
Authors: Cruz de Oliveira Amanda Mazza , Sousa Paloma Vasconcelos , Alves Ana Aline Sousa , Medeiros Stella Regina Arcanjo , Mendonça Maria Jacqueline do Nascimento
Published: March 2020

A segurança na produção de alimentos pode ser obtida por meio da adoção de práticas adequadas de manipulação, uma vez que estas os protegem de contaminações físicas, químicas e biológicas. Por isso, a Agência Nacional de Vigilância Sanitária (ANVISA) exige, por meio de leis, o cumprimento de boas práticas de fabricação (BPF) de alimentos. Com o presente estudo, portanto, objetivou-se verificar o grau de adoção das ações para controle higiênico-sanitário dos alimentos produzidos em serviços de alimentação e a adequação legal dos serviços às normas de BPF. Trata-se de um estudo observacional, descritivo, no qual avaliou-se 34 estabelecimentos das cidades de Tianguá, Ubajara, Ibiapina, São Benedito e Guaraciaba do Norte, por meio da aplicação de uma lista de verificação de boas práticas, baseada na RDC 216/2004 ANVISA, e categorização conforme o grau de atendimento aos itens, como previsto na RDC 275/2002 ANVISA. Verificou-se que a maioria dos serviços de alimentação visitados estão classificados nos grupos II e grupo III, ou seja, atingiram o máximo de 75% de conformidade. Assim, conclui-se que muitos dos estabelecimentos avaliados não adotam as BPF de alimentos da forma correta e, portanto, apresentam percentual baixo de conformidade à lei, carecendo de ações corretivas para garantirem a segurança dos alimentos produzidos.
Editorial 2ª Edição Especial - Mulheres na Ciência
Authors: Morais Ana Cristina da Silva
Published: March 2020

Editorial 2ª Edição Especial - Mulheres na Ciência
Hidroeléctrica Ituango, un caso para el análisis ambiental del territorio
Authors: Cuervo Itzamar Nataly
Published: March 2020

A partir de la investigación, “Factores de desarrollo local en un hábitat afectado por proyectos de desarrollo hidroeléctrico: proyecto Hidroeléctrico Ituango, Antioquia, Colombia”, desarrollada por la autora entre los años 2015 y 2018, este artículo plantea una lectura compleja de los hábitats afectados por proyectos hidroeléctricos. Desde una mirada de las escalas, instituciones y construcción social del hábitat, elabora un panorama de las condiciones de desarrollo promovidas por los megaproyectos, donde se identifican algunas de las inconsistencias de tipo metodológico que se presentan durante la planeación y ejecución de los proyectos. A partir de este ejercicio se proponen unos ejes de análisis, cuyo objetivo es ubicar el desarrollo local dentro de los marcos normativos, como las mismas metodologías empleadas por los mismos proyectos hidroeléctricos una vez intervienen en los territorios. Estos ejes de análisis definen orientaciones para la comprensión de hábitats afectados actualmente y como ruta de atención a otras problemáticas que enfrentan las comunidades y administraciones locales en la implementación de grandes proyectos de desarrollo en Colombia y el mundo.
Diseño de un Jardín Botánico Universitario en áreas de piedemonte llanero: Campus Loma Linda, Universidad Santo Tomas, Villavicencio
Authors: Velosa Caicedo Rodrigo Isaac , Gonzáles Trujillo Juan Manuel
Published: March 2020

Los jardines botánicos han evolucionado hasta convertirse en entornos de conservación de la biodiversidad; su evolución refleja no solo los cambios en los propósitos y deseos de conservación de culturas locales, sino también aquellos en los aportes conceptuales, metodológicos y técnicos de diversas disciplinas del conocimiento (incluidos los cambios de percepción en la manera de apreciar los entornos naturales). Los jardines botánicos universitarios suelen asociarse con fragmentos de vegetación natural de diversos tamaños, en diferentes etapas de sucesión ecológica y dentro del contexto de ecorregiones o zonas de vida específicas; también se vinculan con el mantenimiento de especies nativas, y el desarrollo de actividades de educación, investigación y sensibilización ambiental. Este artículo es producto de una investigación realizada en la Universidad Santo Tomás, Sede Villavicencio, (Meta, Colombia), que tuvo por objeto evaluar la viabilidad ecológica y técnica del establecimiento de un área de jardín botánico en dicha institución: se pretende compartir las reflexiones realizadas en torno a la importancia, los retos y principales impactos de los jardines botánicos como estrategias para conservación de biodiversidad, así como ilustrar los propósitos de planificación y lineamientos de diseño de un jardín botánico universitario en la zona de piedemonte llanero.
Un boxplot bidimensional en coordenadas polares
Authors: Gaviria Carlos , Márquez Fernández Carlos , Guerra Villa César , Acevedo Nanclares Walter
Published: March 2020

En este artículo realizamos una propuesta de un boxplot bidimensional, una extensión del boxplot univariado de Tukey. Este gráfico está conformado por dos polígonos convexos que están orientados en la dirección de una linea recta ajustada, llamada “línea de Tukey”. El boxplot bidimensional tiene una caja interior que contiene el 50% de los datos; un punto interior a dicha caja que denotamos como la “mediana” y una caja externa que separa los valores atípicos. El boxplot bidimensional representa ubicación, extensión, correlación y asimetría de los datos.
Optimal sensor placement for pipe burst detection in water distribution systems using cost–benefit analysis
Authors: Zhao Mengke , Zhang Chi , Liu Haixing , Fu Guangtao , Wang Yuntao
Published: March 2020

Fast detection of pipe burst in water distribution systems (WDSs) could improve customer satisfaction, increase the profits of water supply and more importantly reduce the loss of water resources. Therefore, sensor placement for pipe burst detection in WDSs has been a crucial issue for researchers and practitioners. This paper presents an economic evaluation indicator named as net cost based on cost–benefit analysis to solve the optimal pressure sensor placement problem. The net cost is defined as the sum of the normalized optimal detection uncovering rate and investment cost of sensors. The optimal detection uncovering rate and the optimal set of sensor locations are determined through a single-objective optimization model that maximizes the detection coverage rate under a fixed number of sensors. The optimal number of sensors is then determined by analyzing the relationship between the net cost and the number of sensors. The proposed method is demonstrated to be effective in determining both the optimal number of sensors and their locations on a benchmark network Net3. Moreover, the sensor accuracy and pipe burst flow magnitude are shown to be key uncertainties in determining the optimal number of sensors.
Linking flow velocity-regulated EPS production with early-stage biofilm formation in drinking water distribution systems
Authors: Liu Yanyan , Shan Rongrong , Chen Guowei , Liu Li
Published: March 2020

Hydrodynamics impacts interactions between microbes and their micro-habitats in aqueous systems, thus the study of hydrodynamics is key to understanding the formation and dynamics of biofilms. Yet mechanisms of how microbial responses to hydrodynamics regulate biofilm formation in drinking water distribution systems (DWDS) are underappreciated. Here, we investigated the linkage between early-stage biofilm formation and flow velocity fluctuations in a model DWDS. Results showed that an intermediate velocity (1.0 m/s) enhanced biofilm formation, with the highest biofilm/total cells ratio of 96.91% ± 2.26%. Moreover, the intermediate velocity promoted extracellular polymeric substances (EPS) release, accompanied with lowered zeta potential and elevated hydrophobicity of suspended cells, which could be responsible for surface aggregation. Shifts in biofilm community were observed along with hydrodynamics fluctuations. Intermediate velocity (1.0 m/s) stimulated the dominance of Proteobacteria (78.16%) along with the genus predominance of Pseudomonas, known to secrete large amounts of EPS favoring biofilm formation. Overall, this study provides new understanding of biofilm formation responding to hydrodynamic fluctuations in DWDS.
Antiviral Drug Discovery and Development for Mayaro Fever – What do we have so far?
Authors: Mello Marcos V.P. , Domingos Thaisa F.S. , Ferreira Davis F. , Ribeiro Mariana M.J. , Ribeiro Thayssa P. , Rodrigues Carlos R. , Souza Alessandra M.T.
Published: March 2020

Tropical infectious diseases cause millions of deaths every year in developing countries,
with about half of the world population living at risk. Mayaro virus (MAYV) is an emerging arbovirus
that causes Mayaro fever, which is characterized by fever, headache, diarrhea, arthralgia, and rash.
These symptoms can be clinically indistinguishable from other arboviruses, such as Dengue, Zika, and
Chikungunya, which makes the diagnosis and treatment of the disease more difficult. Though, the Mayaro
virus is a potential candidate to cause large-scale epidemics on the scale of ZIKV and CHIKV.
Despite this, there is no licensed vaccine or antiviral for the treatment of Mayaro fever and most arboviruses,
so the design and development of candidates for antiviral drugs are urgently needed. In this
context, this mini-review aims to provide an overview of studies of anti-MAYV derivatives and highlight
the importance of the discovery and development of promising drug candidates for Mayaro fever.
The Potential Prognostic Performance of Neutrophil CD64 and Monocyte HLA-DR in Patients with Complicated Intra-abdominal Infections
Authors: Dimitrov Evgeni , Halacheva Krasimira , Enchev Emil , Minkov Georgi , Yovtchev Yovcho
Published: March 2020

Background:

Complicated intra-abdominal infections are still associated with a high risk of
an unfavorable outcome. Despite the equal treatment, the mortality rates in some patients’ populations
remain significant, especially when the impaired immune response is present.

Aim:

The object of this research is to analyze the impact of pro-inflammatory neutrophil CD64 and
anti-inflammatory monocyte HLA-DR on the final outcome.

Methods:

We have searched in the PubMed database, the literature relating the prognostic value of two
biomarkers - nCD64 and mHLA-DR in patients with complicated intra-abdominal infections and/or
sepsis.

Results:

Eighteen original studies with 2960 patients fulfilled our inclusion criteria. The data about
nCD64 that we found was contradictory, whereas low mHLA-DR expression showed good prognostic
value.

Conclusion :

Our review showed heterogeneous data about nCD64 survival prediction. Further investigations
with surgical patients exclusively are needed to evaluate its prognostic value in cIAIs. However,
we observed a good prognostic performance of low mHLA-DR expression. After a validation in
larger multicentre studies, mHLA-DR could be used as promising prognostic biomarker in cIAIs.
MARKERS OF NEUROVISULATION IN MIGRAINE DIAGNOSTICS
Authors: Ostashko M. P. , Nasonova T. I.
Published: March 2020

In clinical medicine, the diagnosis of migraine is based on anamnesis and symptoms, and instrumental diagnostic methods are considered non-informative. Numerous studies of the brain, during headaches and between them, have made a significant contribution to understanding the pathophysiology of migraines. Structural and functional changes in the migraine brain are revealed by advanced magnetic resonance imaging techniques, and attempts to detect the visualization markers of this disease progressively increase. This overview article aims to summarize the results of recent studies that reflect achievements in understanding the pathophysiology of migraine, as well as the possibility of using neuroimaging techniques in diagnosing migraines.
ANALYSIS OF THE CONTENT OF IMMUNE COMPLEXES IN BLOOD MILK IN PATIENTS WITH MULTIPLE SCLEROSIS WITH PATHOGENETIC AND DISEASE CHARACTERISTIC THERAPY
Authors: Boychuk M. O. , Bilyy R. O. , Nehrych T. I.
Published: March 2020

In order to determine the activity of multiple sclerosis (MS), in particular for the objective confirmation of exacerbation of the disease, it is proposed to conduct a test for analyzing the antibody to the main myelin protein (OBM) and determining the antibodies to the components of the secondary non-necrotic cells (SNEC).
PREVENTION AND TREATMENT OF MENOPAUSAL DISORDERS WITH THE USE OF PHYTOPREPARATIONS
Authors: Hinchytska L. V. , Lasytchuk O. M. , Neiko O. V.
Published: March 2020

The purpose of our work is to evaluate the clinical manifestations of menopausal disorders in the primary treatment of women and after the proposed complex of non-hormonal treatment. Clinical and laboratory examination of patients of menopausal age was conducted to determine neurovegetative, psycho-emotional, and metabolic-endocrine disorders. The patients were divided into groups as follows: Group I - main, 48 women with physiological menopause up to three years who received a complex of herbal remedies within six months; Group II was a control, 34 women receiving symptomatic treatment for menopausal disorders. The results of the clinical manifestations of climax before and after the use of non-hormonal drugs for six months are presented. Thus, the level of personal anxiety in patients of group I decreased to 30.3 ± 2.8 points (p <0.05), while in group II remained almost at the same level of 40.2 ± 2.5 points (p> 0.05). After the treatment we offered, the percentage of women with climacteric disorders of moderate severity decreased in group I from 54.2% to 18.8%, in II - from 44.1% to 29.4%. The slightly higher rates of physiological menopause in group II women are explained by the fact that patients with severe climax were not included in the treatment group. The effectiveness of this therapy as an alternative method of relief of menopausal manifestations has been established.
HISTOMETRIC AND ULTRASTRUCTURAL ORGANIZATION OF THE NERVIMUSCULAR TERMINALS OF SKELETAL MUSCLES AT A HYPOKINESIA
Authors: Yaschyshyn Z. M. , Popel S. L.
Published: March 2020

The aim: to study the dynamics of histological and ultrastructural changes in muscle fibers and their neuromuscular endings under conditions of prolonged hypokinesia at different stages of ontogenesis.

Methods. Studied skeletal muscles and their peripheral nervous apparatus of laboratory male Wistar rats aged 30 to 270 days. The restriction of motor activity was carried out in special canister cells for 30, 60, 90, and 240 days (5 animals for each term). To determine the type of muscle fiber, the Nahlas histochemical method was used, the Kulchitsky method was used to detect myelinated nerve fibers, the Bilshovsky-Gros method and the electron microscopic method to identify neuromuscular endings.

Results. The data of histological and electron microscopic examination of skeletal muscle fibers and their neuromuscular endings under conditions of prolonged hypokinesia indicate their regular restructuring during the development of muscles, the formation of their synapses and structures that are associated with them at different stages of ontogenesis.

Conclusion. The study provides an in-depth understanding of the relative frequency and nature of the disturbance of the neuromuscular endings during prolonged hypokinesia and its effect on the dynamics of structural adjustment of individual types of muscle fibers in ontogenesis.
AN ELECTRONIC EXCEL-CALCULATOR FOR CALCULATING DENTAL CROWN VOLUMES
Authors: Bulbuk O. I. , Mazurenko V. V. , Rozhko M. M. , Bulbuk O. V.
Published: March 2020

Previous studies have found that with increasing volume of hard tissues defect, the sensitivity of the restored structure to the physical and mechanical restoration characteristics is increasing too. Since existing volume determination techniques cannot be use in a clinical setting, this gives reason to consider the problem of volume determination dental hard tissue defects extremely important, and this research-relevant.

Aims of research. Develop and evaluate the possibility of using methods to determine dental crown volumes and volumes of defects in hard tooth tissue.

Materials and methods of research. For determination of crown volumes and defect volumes of hard tooth tissues for each group of teeth were used appropriate geometric models. Together with the built models, were performed the mathematical calculations to calculate their linear dimensions.

Results of the research. We have developed and substantiated the feasibility of using an electronic Excel calculator to calculate dental crown volumes in clinical settings.

Conclusions. Using our electronic Excel calculator to calculate tooth crown volumes and methods for determining the volume of dental hard tissue defects, in clinical settings we can objectify the diagnostic process in the presence of dental hard tissue defects.
Usability, Acceptability, and Effectiveness of Web-Based Conversational Agents to Facilitate Problem Solving in Older Adults: Controlled Study
Authors: Bennion Matthew Russell , Hardy Gillian E , Moore Roger K , Kellett Stephen , Millings Abigail
Published: March 2020

Background

The usability and effectiveness of conversational agents (chatbots) that deliver psychological therapies is under-researched.

Objective

This study aimed to compare the system usability, acceptability, and effectiveness in older adults of 2 Web-based conversational agents that differ in theoretical orientation and approach.

Methods

In a randomized study, 112 older adults were allocated to 1 of the following 2 fully automated interventions: Manage Your Life Online (MYLO; ie, a chatbot that mimics a therapist using a method of levels approach) and ELIZA (a chatbot that mimics a therapist using a humanistic counseling approach). The primary outcome was problem distress and resolution, with secondary outcome measures of system usability and clinical outcome.

Results

MYLO participants spent significantly longer interacting with the conversational agent. Posthoc tests indicated that MYLO participants had significantly lower problem distress at follow-up. There were no differences between MYLO and ELIZA in terms of problem resolution. MYLO was rated as significantly more helpful and likely to be used again. System usability of both the conversational agents was associated with helpfulness of the agents and the willingness of the participants to reuse. Adherence was high. A total of 12% (7/59) of the MYLO group did not carry out their conversation with the chatbot.

Conclusions

Controlled studies of chatbots need to be conducted in clinical populations across different age groups. The potential integration of chatbots into psychological care in routine services is discussed.
New Path to Recovery and Well-Being: Cross-Sectional Study on WeChat Use and Endorsement of WeChat-Based mHealth Among People Living With Schizophrenia in China (Preprint)
Authors: Yu Yu , Li Yilu , Li Tongxin , Xi Shijun , Xiao Xi , Xiao Shuiyuan , Tebes Jacob Kraemer
Published: March 2020

BACKGROUND

The past few decades have seen an exponential increase in using mobile phones to support medical care (mobile health [mHealth]) among people living with psychosis worldwide, yet little is known about WeChat use and WeChat-based mHealth among people living with schizophrenia (PLS) in China.

OBJECTIVE

This study aims to assess WeChat use, endorsement of WeChat-based mHealth programs, and health related to WeChat use among PLS.

METHODS

We recruited a random sample of 400 PLS from 12 communities in Changsha City of Hunan Province, China. WeChat use was assessed using the adapted WeChat Use Intensity Questionnaire (WUIQ). We also compared psychiatric symptoms, functioning, disability, recovery, quality of life, and general well-being between WeChat users and nonusers using one-to-one propensity-score matching.

RESULTS

The WeChat use rate was 40.8% in this sample (163/400); 30.7% (50/163) had more than 50 WeChat friends and nearly half (81/163, 49.7%) spent more than half an hour on WeChat, a pattern similar to college students and the elderly. PLS also showed higher emotional connectedness to WeChat use than college students. About 80.4% (131/163) of PLS were willing to participate in a WeChat-based mHealth program, including psychoeducation (91/163, 55.8%), professional support (82/163, 50.3%), and peer support (67/163, 41.1%). Compared with nonusers, WeChat users were younger, better educated, and more likely to be employed. WeChat use was associated with improved health outcomes, including lower psychiatric symptoms, lower depression, higher functioning, better recovery, and higher quality of life.

CONCLUSIONS

WeChat-based mHealth programs hold promise as an empowering tool to provide cost-effective interventions, to foster global recovery, and to improve both physical and mental well-being among PLS. WeChat and WeChat-based mHealth programs have the potential to offer a new path to recovery and well-being for PLS in China.
Application of an Isolated Word Speech Recognition System in the Field of Mental Health Consultation: Development and Usability Study (Preprint)
Authors: Fu Weifeng
Published: March 2020

BACKGROUND

Speech recognition is a technology that enables machines to understand human language.

OBJECTIVE

In this study, speech recognition of isolated words from a small vocabulary was applied to the field of mental health counseling.

METHODS

A software platform was used to establish a human-machine chat for psychological counselling. The software uses voice recognition technology to decode the user's voice information. The software system analyzes and processes the user's voice information according to many internal related databases, and then gives the user accurate feedback. For users who need psychological treatment, the system provides them with psychological education.

RESULTS

The speech recognition system included features such as speech extraction, endpoint detection, feature value extraction, training data, and speech recognition.

CONCLUSIONS

The Hidden Markov Model was adopted, based on multithread programming under a VC2005 compilation environment, to realize the parallel operation of the algorithm and improve the efficiency of speech recognition. After the design was completed, simulation debugging was performed in the laboratory. The experimental results showed that the designed program met the basic requirements of a speech recognition system.
An Intelligent Mobile-Enabled System for Diagnosing Parkinson Disease: Development and Validation of a Speech Impairment Detection System (Preprint)
Authors: Zhang Liang , Qu Yue , Jin Bo , Jing Lu , Gao Zhan , Liang Zhanhua
Published: March 2020

BACKGROUND

Parkinson disease (PD) is one of the most common neurological diseases. At present, because the exact cause is still unclear, accurate diagnosis and progression monitoring remain challenging. In recent years, exploring the relationship between PD and speech impairment has attracted widespread attention in the academic world. Most of the studies successfully validated the effectiveness of some vocal features. Moreover, the noninvasive nature of speech signal–based testing has pioneered a new way for telediagnosis and telemonitoring. In particular, there is an increasing demand for artificial intelligence–powered tools in the digital health era.

OBJECTIVE

This study aimed to build a real-time speech signal analysis tool for PD diagnosis and severity assessment. Further, the underlying system should be flexible enough to integrate any machine learning or deep learning algorithm.

METHODS

At its core, the system we built consists of two parts: (1) speech signal processing: both traditional and novel speech signal processing technologies have been employed for feature engineering, which can automatically extract a few linear and nonlinear dysphonia features, and (2) application of machine learning algorithms: some classical regression and classification algorithms from the machine learning field have been tested; we then chose the most efficient algorithms and relevant features.

RESULTS

Experimental results showed that our system had an outstanding ability to both diagnose and assess severity of PD. By using both linear and nonlinear dysphonia features, the accuracy reached 88.74% and recall reached 97.03% in the diagnosis task. Meanwhile, mean absolute error was 3.7699 in the assessment task. The system has already been deployed within a mobile app called No Pa.

CONCLUSIONS

This study performed diagnosis and severity assessment of PD from the perspective of speech order detection. The efficiency and effectiveness of the algorithms indirectly validated the practicality of the system. In particular, the system reflects the necessity of a publicly accessible PD diagnosis and assessment system that can perform telediagnosis and telemonitoring of PD. This system can also optimize doctors’ decision-making processes regarding treatments.
Tinjauan Singularitas Ruang-waktu dalam Teori Relativitas Umum menggunakan Software Maxima
Authors: Jihad Ibnu , Wardhani Devy Pramudyah , Rosyid Muhammad Farchani
Published: March 2020

Singularitas ruang-waktu pada teori relativitas umum telah ditinjau. Definisi singularitas telah diperjelas menggunakan kriteria singularitas berdasarkan skalar Kretschmann. Letak Daerah singularitas pada tiga jenis ruang-waktu pun telah diketahui berdasarkan perhitungan skalar Kretschmann menggunakan software gratis Maxima yang sangat mempermudah perhitungannya. Tiga jenis ruang-waktu itu adalah ruang-waktu bermetrik Schwarzschild, ruang-waktu bermetrik Reissner-Nordstorm, serta ruang-waktu bermetrik Robertson-Walker dengan model alam semesta Einstein-de Sitter.
End Points for Clinical Trials in Primary Hyperoxaluria
Authors: Milliner Dawn S. , McGregor Tracy L. , Thompson Aliza , Dehmel Bastian , Knight John , Rosskamp Ralf , Blank Melanie , Yang Sixun , Fargue Sonia , Rumsby Gill , Groothoff Jaap , Allain Meaghan , West Melissa , Hollander Kim , Lowther W. Todd , Lieske John C.
Published: March 2020

Patients with primary hyperoxaluria experience kidney stones from a young age and can develop progressive oxalate nephropathy. Progression to kidney failure often develops over a number of years, and is associated with systemic oxalosis, intensive dialysis, and often combined kidney and liver transplantation. There are no therapies approved by the Food and Drug Association. Thus, the Kidney Health Initiative, in partnership with the Oxalosis and Hyperoxaluria Foundation, initiated a project to identify end points for clinical trials. A workgroup of physicians, scientists, patients with primary hyperoxaluria, industry, and United States regulators critically examined the published literature for clinical outcomes and potential surrogate end points that could be used to evaluate new treatments. Kidney stones, change in eGFR, urine oxalate, and plasma oxalate were the strongest candidate end points. Kidney stones affect how patients with primary hyperoxaluria feel and function, but standards for measurement and monitoring are lacking. Primary hyperoxaluria registry data suggest that eGFR decline in most patients is gradual, but can be unpredictable. Epidemiologic data show a strong relationship between urine oxalate and long-term kidney function loss. Urine oxalate is reasonably likely to predict clinical benefit, due to its causal role in stone formation and kidney damage in CKD stages 1–3a, and plasma oxalate is likely associated with risk of systemic oxalosis in CKD 3b–5. Change in slope of eGFR could be considered the equivalent of a clinically meaningful end point in support of traditional approval. A substantial change in urine oxalate as a surrogate end point could support traditional approval in patients with primary hyperoxaluria type 1 and CKD stages 1–3a. A substantial change in markedly elevated plasma oxalate could support accelerated approval in patients with primary hyperoxaluria and CKD stages 3b–5. Primary hyperoxaluria type 1 accounts for the preponderance of available data, thus heavily influences the conclusions. Addressing gaps in data will further facilitate testing of promising new treatments, accelerating improved outcomes for patients with primary hyperoxaluria.
Art and Aesthetic Education
Authors: Lutfi Dina A.M.
Published: March 2020

This paper explores Maxine Greene’s views on aesthetic pedagogy and the notion of social imagination, in addition to Grant Kester’s views on dialogical art. These approaches are a call for action in art education, in addition to aesthetic approaches that can be applied in other fields of education. Aesthetic pedagogy offers educators and students a sense of intellectual autonomy, and may also facilitate alternative ways of generating meaning. I argue that making art is one part of the educational experience, however, aesthetic experiences also occur when people look at art and discuss it collectively. I encourage educators to adopt an approach of discovery, which is fueled by the outcome of open-ended discussions, and mainly focuses on different individual experiences. Educators may create opportunities for change through engaging in aesthetic experiences in their own daily lives and practices. Aesthetic experiences and aesthetic education foster independent thinking in students and encourages them to be more mindful of their feelings, surroundings, and expressions. Young minds should be educated to be inquisitive, to critique, and become open to possibilities and experiences they may have not considered, which transforms learning from passive to active.
Система на кристалле SmartFusion2 от Microsemi: оптимальное решение для Интернета вещей
Authors: Ежов В.
Published: March 2020

В статье рассмотрены особенности СнК на базе ПЛИС семейства SmartFusion2 от Microsemi, которые полностью отвечают всем требованиям IoT-инфраструктуры и позволяют создавать гибкие системы, отличающиеся минимальной потребляемой мощностью и самым высоким уровнем защиты, доступным для ПЛИС.
Применение ПЛИС класса «система на кристалле» Xilinx Zynq и подходы к проектированию на основе языков описания аппаратуры высокого уровня
Authors: Тарасов И.
Published: March 2020

Рассмотрены возможности существующих и перспективных семейств программируемых логических интегральных схем компании Xilinx с архитектурой «система на кристалле», а также предпочтительные подходы к проектированию цифровых систем под управлением процессоров на основе САПР Xilinx Vivado HLS.
Los cuentos de Canterbury, de XXX a clasificación A
Authors: Murgia Elizalde Mario
Published: March 2020

The Canterbury Tales has been widely translated and modernised for the benefit of large audiences who are unacquainted with what John Dryden once called Chaucer’s “rough style”. The translations of Chaucer’s masterpiece into Spanish —the main topic of this essay— are scarce but noteworthy, nonetheless. Their interest lies in the fact that the translation of supposedly lewd or sexually explicit passages tends to be irregular in terms of their degree of explicitness. This essay explores the degree to which Chaucer’s‘ lewdness’ has been preserved (or nullified) in translations by Pedro Guardia Massó, Jesús L. Serrano Reyes and Antorio R. León Sandra. The possible reasons that underlie the translators’ modifications in terms of idiom and/or register in their Spanish versions are also discussed.
BREVE DIÁLOGO ENTRE “SENTIDOS DO AMOR” E O PENSAMENTO DE MERLEAU-PONTY BRIEF DIALOGUE BETWEEN "SENTIDOS DO AMOR" AND THE THOUGHT BY MERLEAU-PONTY
Authors: Marton Silmara Lídia
Published: March 2020

ResumoArte e filosofia assumidas em sua tarefa de provocar a expressão primordial do sentir-pensar, juntas, proporcionam uma compreensão mais ampla de nossa condição no mundo que, sua por sua vez, é feita de relações que não são puras mediante o exercício de um pensamento formal e lógico a dominar os objetos a sua volta, mas por relações de seres encarnados feitas de perspectivas que abrem e recobrem, continuamente. Nessa perspectiva, o texto se propõe a realizar um diálogo entre a arte do cinema a partir do filme “Sentidos do Amor”, dirigido por David Mackenzie e a filosofia de Merleau-Ponty, cuja abordagem fenomenológica nos desloca para uma percepção da radicalidade de nossa existência como corporeidade e possibilidade autêntica de produção de sentidos.Palavras-chave: Arte. Filosofia. Fenomenologia. Cinema. Sentidos. AbstractArt and philosophy assumed in their task of provoking the primordial expression of feeling-thinking, together, provide a broader understanding of our condition in the world which, in turn, is made of relationships that are not pure through the exercise of a thought formal and logical that dominate the objects around him, but by relationships of incarnated beings made of perspectives that open and cover, continuously. In this perspective, the text proposes to make a dialogue between the art of cinema from the film "Senses of Love", directed by David Mackenzie and the philosophy of Merleau-Ponty, whose phenomenological approuch moves us to a perception of the radicality of our existence as corporeity and authentic possibility of meaning production.Keywords: Art. Philosophy. Phenomenology. Cinema. Senses.
NA CONTRAMÃO DA MEDICALIZAÇÃO NA EDUCAÇÃO: DESNATURALIZAR E DESPATOLOGIZAR O FRACASSO ESCOLAR ON THE OPPOSITE WAY OF MEDICALIZATION IN EDUCATION: DENATURIZING AND DEPATHOLOGIZING SCHOOL FAILURE
Authors: Ferreira Danielle De Almeida Galante
Published: March 2020

O objeto deste estudo são as dificuldades de escolarização interceptadas pela medicalização dos fenômenos educacionais em meio à produção ideológica dofracasso escolar. A investigação objetivou verificar a epidemia de diagnósticos e de tratamentos do suposto fracasso escolar na sociedade contemporânea; bem como pensar em formas de intervenção do problema da patologização e da caracterização do fracasso escolar que considerem a brincadeira como essencial para identificar asnecessidades do aprendiz. Por meio da revisão bibliográfica, almeja-se refletir acerca de alternativas à medicalização das dificuldades de aprendizagem na prática educacional e que resgatem o prazer em aprender. The object of this study is the difficulties of schooling intercepted by the medicalization of educational phenomena in the midst of the ideological production of school failure.The investigation aimed to verify the epidemic of diagnoses and treatments of the supposed scholastic failure in the contemporary society; as well as to think of ways ofintervention of the problem of the pathologization and the characterization of school failure that consider play as essential to identify the needs of the learner. Through thebibliographic review, it is sought to reflect on alternatives to the medicalization of learning difficulties in educational practice and that rescue the pleasure in learning.
RÊVERIE ET « PSYCHISME HYDRANT » CHEZ YASUNARI KAWABATA DANS "LA DANSEUZE D’IZU (IZU NO ODORIKO", 1926)
Authors: FRENŢIU Rodica
Published: March 2020

Reverie and Water Psychism in Yasunari Kawabata’s La Danseuse d’Izu (Izu no odoriko, 1926). The present study approaches Yasunari Kawabata’s novel La Danseuse d’Izu (Izu no odoriko, 1926) from a new perspective, in terms of an open experience. The writer’s particular textual poetics deploys a lyrical neo-sensualism which provides a unique combination of linguistic simplicity and literary ambiguity. Among the many shapes taken by the poetic imagination, the imagination of the matter relies on active substances which the ”unconscious of form” can call for in order to provide the unity and the internal hierarchy of the artistic expression. My analysis explores the range of poetic images employed by the Japanese novel, focusing on the iterations of a fundamental matter, the water. Despite its oneiric potential, the theme has a poetic stability able to ground the narrative. Kawabata’s writing is prone to spiritual focusing, spontaneity, and reverie, but builds upon a certain type of syntax, which places the images in continuous connection, but also seems to ”unbind” the object-related reverie. Water psychism reigns over the language of the narrative analyzed in this paper, with the effect of making the text continuously ”fluid”, and the phrasing rhythms nuanced enough to convey the mysteries hidden within the words.
REZUMAT. Reveria şi psihismul acvatic la Yasunari Kawabata, Dansatoarea din Izu (Izu no odoriko, 1926). Studiul de faţă propune pentru romanul La Danseuse d’Izu (Izu no odoriko, 1926), semnat de Yasunari Kawabata, o nouă lectură, ca o experienţă deschisă, încercând să evidenţieze particularităţile poeticii textuale a unui neo-senzualist liric ce combină simplitatea lingvistică şi ambiguitatea literară într-un mod unic. Dar, sub nenumăratele-i forme, imaginaţia poetică ascunde şi o imaginaţie a materiei, ce privilegiază o substanţă activă revendicată în „inconştientul formei”, care determină unitatea şi ierarhia expresiei. Argumentaţia noastră încearcă să probeze, pornind de la materia imaginilor poetice oferite de romanul japonez, tema unei materii fundamentale, cea a apei, a cărei putere onirică se transformă într-o soliditate poetică ce conferă unitate naraţiunii. Aplecată înspre concentrarea spirituală, spontaneitate şi reverie, scriitura aduce cu sine un anumit tip de sintaxă, o legătură continuă între imagini, ce „desprinde” parcă reveria legată de obiecte. Mai mult, psihismul acvatic pare să fi înstăpânit limbajul în textul narativ supus analizei, conferindu-i o „fluiditate” continuă, ce mlădiază ritmul frazei şi scoate la iveală misterele ascunse de cuvânt.
Cuvinte-cheie: limbaj poetic, psihism acvatic, fluiditate, reverie, frumuseţe estetică
THE MASK AVATARS IN THE WORKS OF MISHIMA YUKIO AND ROLE PLAYED BY THE SUBJECT-OBJECT RELATION
Authors: ILIS Florina
Published: March 2020

The Mask Avatars in the Works of Mishima Yukio and Role Played by the Subject-Object Relation. In understanding the autobiographical aspects present in the works of Mishima, addressing the Subject-Object relation is essential – a relation implicitly suggested and justified by the term mask used in the title Confessions of a Mask. The present paper shall try to analyse the variations of the functioning mechanism of this relation in Confessions of a Mask (Kamen no kokuhaku/ 仮面の告白, 1949), The Temple of the Golden Pavilion (Kinkaku-ji/ 金閣寺, 1956) and The Sea of Fertility (Hōjō no Umi/ 豊饒の海, 1965-1970). Moreover, with respect to the dialectics of the Subject-Object relation, we shall identify the mask avatars that, on an epic level, produce a real hallucinating effect, by hiding and, at the same time, revealing the intentions of the hero and/or of the author. The face, the appearance and the make-up as avatars of the hero’s mask are also expressions of the narrator’s identity, thus creating the illusion that, in Confessions of a Mask, we are not faced with the referentiality of language in the name of which the textual world is constructed, but the inner reality of the author himself. The narrator fades behind the mask in order to create the effect of reality: the illusion of the presence of the Author. A true master of the mask, Mishima Yukio gives the readers the illusion that they are facing the author himself, when, in fact, they are merely taking part in a cleverly staged game.
REZUMAT. Avatarurile măștii în opera lui Mishima Yukio și rolul raportului Subiect-Obiect. Pornind de la ideea că, în înțelegerea aspectelor autobiografice ale operei lui Mishima este esențială punerea în discuție a raportului dintre Subiect-Obiect, raport pe care, implicit, îl sugerează și îl justifică cuvântul mască din titlul Confesiunilor unei măști, vom încerca să analizăm variațiile mecanismului de funcționare a acestui raport în Confesiunile unei măști (Kamen no kokuhaku/ 仮面の告白, 1949), Templul de aur (Kinkaku-ji 金閣寺, 1956) și Marea fertilității (Hōjō no Umi/ 豊饒の海, 1965-1970). De asemenea, în raport cu dialectica relației Subiect-Obiect, vom identifica avatarurile măștii care produc în plan epic un efect halucinatoriu de real, ascunzând și, simultan, demascând intențiile eroului și/sau autorului. Fața, chipul și machiajul ca avataruri ale măștii eroului sunt totodată expresii ale identității naratorului, dându-ne iluzia că, în Confesiunile unei măști, nu ne confruntăm cu referențialitatea limbajului în virtutea căreia se construiește lumea textului, ci cu realitatea interioară a autorului însuși. Naratorul se estompează în spatele măștii pentru a crea efectul de real: iluzia prezenței Autorului. Adevărat maestru al măștii, Mishima Yukio dă cititorului iluzia că care are de-a face cu autorul însuși, când, de fapt, nu participă decât la un joc abil înscenat.
Cuvinte-cheie: ficţiune autobiografică, literatura japoneză modernă, narativitate
DECODIFYING JAPANESE ONOMATOPOEIA: A STUDY CASE OF LAUGHTER IN THE COMIC BOOK “KAMISAMA HAJIMEMASHITA”
Authors: TOŞU Ioana Ruxandra
Published: March 2020

Decodifying Japanese Onomatopoeia: A Study Case of Laughter in the Comic Book Kamisama Hajimemashita. This article explores the possibility of translating Japanese onomatopoeia used as role language markers, from Japanese (source language) into Romanian (target language). The study case is conducted on a Japanese comic book (manga), analysed in terms of pragmatic sense conveyed through a multimodal text – various semiotic systems (verbal, images, layout, etc.) that interact and produce a coherent meaning.
REZUMAT. Decodificarea onomatopeelor din limba japoneză: studiu de caz – exprimarea râsului în banda desenată Kamisama Hajimemashita. Acest articol explorează posibilitatea de a traduce onomatopeele din limba japoneză (limba sursă), folosite ca marcatori ai limbajului personificator, în limba română (limba țintă). Studiul de caz este realizat pe o carte de benzi desenate japoneze (manga), analizată din perspectiva sensului pragmatic transmis printr-un text multimodal - diverse sisteme semiotice (verbale, imagini, aranjare în pagină etc.) care interacționează și produc un sens coerent.
Cuvinte-cheie: onomatopee, yakuwarigo, texte multimodale, pragmatică
A CULTURAL HISTORY OF IMPERIAL CIVIL EXAMINATION TO CONTEMPORARY CHINESE EXAMINATION
Authors: KAI Chen
Published: March 2020

A Cultural History of Imperial Civil Examination to Contemporary Chinese Examination. Examination is an evaluation to check if students understand the lessons as well as a stimulating method to help students have progress efficiently. With the long history of imperial civil examination, Chinese examination in modern society is of rigorousness and high-difficulty, and exam-oriented education is very popular. Examination system with influence from imperial civil examination has its advantages and disadvantages, and Chinese language examination designed by Chinese teachers with Chinese exam features is not very welcomed by foreign students. This paper is to have a comprehensive understanding of imperial civil examination in view of its development, its relationship with Confucianism and its influence to contemporary Chinese language education. With the comparison of attitudes to exam, exam function, question design between Chinese exam and Romanian exam, we can make use of the advantages of various exam mechanisms to improve students’ language level, knowledge of culture, and dialectic thinking.
REZUMAT. O istorie culturală de la examinarea civilă imperială şi până la examinarea chinezească contemporană. Examinarea este o evaluare al cărei scop este acela de a verifica dacă studenţii au înţeles lecţiile predate, dar, în acelaşi timp, reprezintă şi o metodă stimulatoare, care îi ajută pe studenţi să cunoască un rapid progress. Având în spate istoria îndelungată a examinării civile imperiale, examinarea chinezească din societatea modernă este una riguroasă şi extrem de dificilă, educaţia orientată spre examinare fiind foarte populară în prezent. Acest sistem de examinare derivat din examinarea civilă imperială are avantajele şi dezavantajele sale, examinarea nivelului de cunoaştere a limbii chineze gândit de profesorii chinezi, potrivit specificului examenelor chinezeşti, nefiind foarte apreciată de studenţii străini. Acest articol îşi propune să ofere o înţelegere comprehensivă a examinării civile imperiale de-a lungul etapelor sale de dezvoltare, relaţiei cu sistemul filosofic confucianist precum şi influenţa sa asupra studierii limbii chineze contemporane. Comparând atitudinea faţă de examinare, funcţia şi structura examinării în sistemul de educaţie chinezesc şi românesc, se pot folosi avantajele cunoaşterii mai multor mecanisme de examinare, cu scopul de a îmbunătăţi nivelul de limbă, cultură şi gândire dialectică al studenţilor.
Cuvinte cheie: examinarea civilă imperial, Confucianism, educaţie contemporană.