bluuebunny/crossref_metadata_2025 huggingface dataset:
A Method for Controlling Series and Parallel Nonlinear Time-Varying LRC Circuits
Authors: Ates Muzaffer , Ates Muhammet
Published: December 2022

Series and parallel LRC circuit systems are widely encountered in numerous electrical, electronics, control issues and
differential equation applications. Accurate control of the current in series and voltage in parallel LRC circuit systems with nonlinear
time-varying inductance, resistance and capacitance is a challenge. In this study, a novel approach proposed for control of current in
nonlinear time-varying series LRC circuit and voltage in nonlinear and time-varying parallel LRC circuit. The proposed controller is
characterized by a nonlinear algebraic equation and straining the tracking error converge to zero. Illustrative results confirm the
proposed approach for forcing the current /voltage in series and parallel nonlinear time-varying LRC circuit to follow the targeted
current /voltage trajectories efficiently. The proposed approach shows great novelty to determine the dynamics behavior of nonlinear
time-varying systems. Therefore, the obtained results generalize and improve the existing conclusions. Simulations illustrate the
feasibility and validity of the theoretical results.
On Feng Qi-type integral inequalities for local fractional integrals
Authors: Akkurt Abdullah , Sarıkaya Mehmet Zeki , Budak Hüzeyin
Published: December 2022

In this paper, we establish the generalized Qi-type inequality involving local fractional integrals on fractal sets
R
α (0 < α < 1) of real line numbers. Some applications for special means of fractal sets R
α are also given. The results presented here
would provide extensions of those given in earlier works.
On One-Point Time on an Oriented Set
Authors: Grushka Yaroslav
Published: December 2022

The notion of oriented set is the basic elementary concept of the theory of changeable sets. The main motivation for the introduction of changeable sets was the sixth Hilbert problem, that is, the problem of mathematically rigorous formulation of the fundamentals of theoretical physics. In the present paper the necessary and sufficient condition of the existence of one-point time on an oriented set is established. From the intuitive point of view, one-point time is the time associated with the evolution of a system consisting of only one object (for example, from one material point). Namely, it is proven that the one-point time exists on the oriented set if and only if this oriented set is a quasi-chain. Also, using the obtained result, the problem of describing all possible images of linearly ordered sets is solved. This problem naturally arises in the theory of ordered sets.
Oligonucleotide Therapeutics for Age-Related Musculoskeletal Disorders: Successes and Challenges
Authors: Nicholson Thomas A. , Sagmeister Michael , Wijesinghe Susanne N. , Farah Hussein , Hardy Rowan S. , Jones Simon W.
Published: December 2022

Age-related disorders of the musculoskeletal system including sarcopenia, osteoporosis and arthritis represent some of the most common chronic conditions worldwide, for which there remains a great clinical need to develop safer and more efficacious pharmacological treatments. Collectively, these conditions involve multiple tissues, including skeletal muscle, bone, articular cartilage and the synovium within the joint lining. In this review, we discuss the potential for oligonucleotide therapies to combat the unmet clinical need in musculoskeletal disorders by evaluating the successes of oligonucleotides to modify candidate pathological gene targets and cellular processes in relevant tissues and cells of the musculoskeletal system. Further, we discuss the challenges that remain for the clinical development of oligonucleotides therapies for musculoskeletal disorders and evaluate some of the current approaches to overcome these.
Association between Renal Stones Sonographic Findings and Demographic Data among Patients at Riyadh Hospitals, Saudi Arabia
Authors: Hassan Mahasin , Alshammrani Tahani , Alshammeri Shahad , Alotaibi Faten , Alzeryer Sara , Alharbi Reem , Almujalli Amal , Mansour Sahar , Luttfi Ibrahim , Elmahdi Tasneem , Bushara Lubna , Hawesa Halima
Published: December 2022

Background: Ultrasound is the primary imaging modality to identify renal stones (RS) in patients with acute flank pain. This study aimed to evaluate the presence, location, and size of RS diagnosed by ultrasound in association with age, gender, and BMI among patients at Riyadh hospitals. Methods and Results: In this case-control study, a total of 250 records (130/52% for males and 120/48% for females) from 2018 to 2019 were reviewed from January to March 2020 at different hospitals in Riyadh. In this study, 150(60%) records of patients with RS and 100(40%) records of patients without RS were collected to evaluate the risk factor for RS formation in the central area of Saudi Arabia. A designed data collection sheet containing all variables (demographic and sonographic) of the study was used. Demographic data included gender, age, and body mass index (BMI). Sonographic data included RS presence (yes, no), RS location (right kidney [RK], left kidney [LK], both kidneys), and RS size (small [<0.5cm], average [0.5–1cm], and large [>1cm]). The study found that RS were more common among males than females (P<0.001). The results show that in normal BW, the frequency of stone presence was similar for RK and LK. In overweight patients, RS were more often observed in LK (P=0.000). We also found a significant association between BMI and RS size (P=0.049); the presence of smaller stones increases with BMI. There was no association between sonographic data and age (P>0.05) Conclusion: Among patients at Riyadh hospitals, females are less affected by RS than males. Gender is a significant risk factor for the development of RS. The effect of BMI is obvious on renal stone location and size.
Bacterial Leakage Evaluation of Three Root Canal Sealers with Two Obturation Techniques: An in Vitro Study
Authors: Kelmendi Tringa , Dula Linda , Kosumi Shera , Kamberi Anila , Kelmendi Nita
Published: December 2022

Background: The purpose of this study was to compare the quality of the coronal seal of three root canal sealers and two obturation techniques using the bacterial penetration method. Methods and Results: A total of 132 single-rooted human teeth with fully developed apices were used. The teeth were randomly assigned to three experimental groups according to the endodontic sealer used. Group 1: Samples (n=44) were obturated using a zinc oxide eugenol-based sealer, Pulp Canal Sealer EWT. Group 2: Samples (n=44) were obturated using an epoxy resin-based sealer, AH Plus. Group 3: Samples (n=44) were obturated using a bioceramic-based root canal sealer, Well-Root ST. Each group was subdivided into 2 equal subgroups in accordance with the obturation technique being used: CLCT and ThOT. Thus, 6 subgroups were formed: Sub-1A: Pulp Canal Sealer/CLCT; Sub-2A: AH Plus/CLCT; Sub-3A: Well-ROOT ST/CLCT; Sub-1B: Pulp Canal Sealer/ThOT; Sub-2B: Ah Plus/ThOT; Sub-3B: Well-ROOT ST/ThOT. A dual-chamber device was used to evaluate bacterial leakage. Fresh medium and E. faecalis were added to the upper chamber every 4 days. The broth was monitored for color change daily for 33 days. Significant differences were found among Sub-2A vs. Sub-1B (P=0.023), Sub-1A vs. Sub-3A (P=0.014), Sub-1A vs. Sub-2B (P=0.024), Sub-1A vs. Sub-3B (P=0.002), Sub-3A vs. Sub-1B (P=0.003), Sub-2B vs. Sub-1B (P=0.005), and Sub-1B vs. Sub-3B (P<0.0001). There was no significant difference in the average occurrence of turbidity between CLCT and ThOT (P=0.718) Conclusion: Regardless of the obturation technique, all root canal sealers exhibited leakage; however, the bioceramic-based root canal sealer appeared to perform better than the epoxy resin-based sealer and the zinc oxide eugenol-based sealer.
Shear Bond Strength of Two Self-Etching Adhesives to Air-Abraded Dentin: An in Vitro Study
Authors: Melkumyan Timur , Musashaykhova Shahnoza , Khabadze Zurab , Makeeva Maria , Dashtieva Marina , Kakhkharova Diloro , Dadamova Angela
Published: December 2022

Background: The aim of this research was to study the effect of air-abrasive treatment of dentin on the chemical composition of its surface and the adhesion strength of 2 self-etching adhesive systems (AS). Methods and Results: Powders based on aluminum oxide (Al2O3) (27µm) (KaVo, Biberach, Germany), sodium bicarbonate (NaHCO3) (40µm) (AIR-FlOW Classic Comfort, EMS, Nyon, Switzerland), and erythritol (14µm) (AIR-FLOW Plus, EMS, Nyon, Switzerland) were used for the air-abrasive treatment of adhesive surfaces. Bonding steps were carried out with Single Bond Universal (SBU) (3M ESPE, USA) and Bond Force 2 (BF2) (Toquyama, Japan). The adhesion strength of composite to dentin was evaluated on 80 samples prepared in accordance with the Ultradent Shear Bond Strength test. All samples were divided into 4 groups depending on the method of dentin surface processing. In the samples of Group 1 (n=20), aluminum oxide was used for the air-abrasive treatment of dentin. In Group 2 (n=20) and Group 3 (n=20), samples were treated using powders based on sodium bicarbonate and erythritol, respectively. Group 4 (control, n=20) included tooth samples in which the dentin surface was not air-abraded after preparation with carbide burs. Then, each group was divided into 2 subgroups (Sub-A and Sub-B) depending on the type of adhesive system used. Adhesive resin was applied and polymerized in accordance with the manufacturer’s instructions. Single Bond Universal (SBU) was used for the samples of Sub-A, and Bond Force 2 (BF2) (Toquyama, Japan) was used for the samples of Sub-B. Scanning electron microscopy and determining the surface elemental composition of samples were carried out on an SEM-EVO MA 10 (Carl Zeiss) and energy dispersive X-ray spectrometer with EDS Aztec Energy Advanced X-Act (Oxford Instruments). It was concluded that air-abrasive treatment of the dentin surface does not enhance the adhesion strength of composite material when using self-etch AS. Also, it was noted that the pH level of self-etch AS is not a crucial feature in determining the strength of the filling-tooth interface. The resulting variations in the elemental composition of dentin surface after air-abrasion with various mixtures and their effect on the efficacy of the different AS require further in vitro studies.
Determination of Mercury in Dental Hard Tissue: An in Vitro Study
Authors: Ajeti Nexhmije , Vula Violeta , Stavileci Miranda , Emini Lindihana
Published: December 2022

The purpose of this study was to determine the levels of mercury in hard tissue from dental amalgam fillings under in vitro conditions. Methods and Results: The study included 30 human teeth that were extracted for various clinical reasons. The teeth were stored in a physiological solution until they were used. The teeth were divided into 3 experimental groups: Group 1 (n=10) – occlusal surface cavity preparation (class I according to Black); Group 2 (n=10) – proximal-occlusal surface cavity preparation (class II); and Group 3 (n=10) – mesio-occlusal-distal [MOD] surface cavity preparation. Each of these groups was divided into 2 subgroups: subgroup 1 (n=5) – amalgam fillings were not polished, and subgroup 2 (n=5) amalgam fillings were polished. The teeth were filled with amalgam, and those in subgroups 2 were polished after 24 hours. The amount of mercury released from the amalgam fillings was determined 9 months after the teeth were filled. Before chemical analysis, the teeth were irrigated 4 times over a period of 10 minutes in an ultrasonic bath. From each tooth, 250mg of the powder was mineralized with royal water (HCl+HNO3 in a ratio of 1:3) in a microwave oven, for 54 minutes. After mineralization, the samples were filtered and analyzed with inductively coupled plasma optical emission spectrometry. The average mercury level after polishing the amalgam filling was significantly smaller (P=0.032) only in Group 1. The average mercury levels in the 3 groups revealed significant differences between both the unpolished samples (one-way ANOVA F = 69.54, P < 0.001) and the polished samples (one-way ANOVA F = 110.54, P < 0.001). Group 3 with MOD surface cavity preparation was characterized by the highest mercury levels. Conclusion: The teeth with an MOD amalgam restoration are characterized by the highest mercury levels. The more mercury is released from unpolished amalgam fillings than from polished amalgam fillings in teeth with occlusal surface cavity preparation (class I according to Black).
Scenarios for Increasing, Decreasing and Stability of Tpe/QT Ratio (Simulation Study)
Authors: Arteyeva Natalia , Azarov Jan
Published: December 2022

The objective of this simulation was to study the physiological meaning of the novel index for arrhythmic risk stratification – Tpe/QT ratio (the interval from the peak to the end of the T-wave (Tpe) on electrocardiogram divided by QT interval). Methods and Results: The role of two factors determining Tpe/QT ratio – action potential duration (APD) and dispersion of repolarization (DOR) – was studied in silico at two levels: ventricular wall segment and the whole heart ventricles. The simulations performed in the framework of both the segment and the entire ventricles’ models showed that Tpe/QT magnitude reflects the dynamic relationship between the longest and the shortest APD rather than the magnitude of DOR, as interval Tpe does. Tpe/QT ratio remained unchanged even at large DOR, provided that the longer the ventricular APD, the greater the gap between the longest and the shortest of them. The imbalance between the longest and the shortest APD values led to the increased or decreased Tpe/QT. Conclusion: Simulations showed that Tpe/QT is not just a corrected Tpe interval, but it reflects the balance between the longest and the shortest APD in the heart ventricles.
Homology in Structural and Functional Organization of the Fibrous Framework of the Derma and Paraneural Connective Tissue Components
Authors: Dzharu Anastasia , Mishina Ekaterina , Zatolokina Mariya , Borodina Karina , Novikov Maksim , Kachmarskaya Ludmila
Published: December 2022

Background: The recent increase in hostilities throughout the globe is one of the main factors that damage both the skin and peripheral nerves (PN), mainly of the upper and lower extremities. The duration of treatment of the injured limb and the rate of recovery of its functions are directly related to the structural integrity of the connective tissue (CT) sheath apparatus of the PN, which further actualizes the study of its micromorphological components. The structural integrity of the peripheral nerve includes not only the preservation of its conductive component but also the membranes surrounding it, providing complete morphofunctional unity. Thus, the study of the features of their tissue organization, vascularization and innervation, with the obligatory comparison of data with homologous tissue of different topography and possible extrapolation of data, determined the purpose of this work. The aim of this study was to analyze the dynamics of changes in the fibrous components of the paraneurium and dermis in onto- and phylogenesis under the influence of various factors and to compare the data obtained for their further extrapolation. Methods and Results: The study was conducted on mature male Wistar rats under standard vivarium conditions. The material for the study was the CT sheaths of the PN of the extremities and skin areas, 1x1 cm in size, to the depth of the subcutaneous fascia of animals. The cadaver material was taken on Days 1, 3, 7, 10, and 28 of ontogeny. The resulting biomaterial was fixed in a 10% buffered neutral formalin solution and embedded in paraffin, according to the standard method. Microtomized, the resulting histological sections were stained with hematoxylin and eosin, according to the method of Mallory and Van Gieson. A comprehensive morphological study was performed using light and electron microscopy. The study revealed the presence of two stages in the ontogeny of the CT, forming the dermis of the skin and paraneural CT structures of PN. In the first stage, structural elements are formed, considering the topography of the CT; in the second, they are differentiated, leading to a qualitative-quantitative transformation due to the appearance of a number of additional functions, an active period of body growth, and taking into account the action of various environmental factors. At earlier stages of ontogenesis, thin, flattened fibrous structures without a clear organization are observed in the field of view in the dermis of the skin. In the paraneurium, the components that form it are not sufficiently expressed. At later periods, the shape and architectonics of the fibrous component change, structurization and an increase in the thickness of the fibers occur and pronounced heterogeneity of the cellular component is observed.
Response of Human Malignant Glioma Cells to Asymmetric Bipolar Electrical Impulses
Authors: Abd-Elghany Amr , Yousef A
Published: December 2022

Electric and electromagnetic pulses have been shown to enhance the endocytosis rate, with all-or-nothing responses beyond a field strength threshold and linear responses as a function of field strength and treatment duration utilizing bipolar symmetrical and monopolar pulses, respectively. Malignant glioma (MG) is resistant to chemotherapy. The present study looked for a new electrical impulse that can aid electrochemotherapy to deliver anticancer drugs while using less electrical energy. Bipolar asymmetric electric pulses were applied to U251MG cells suspended in physiologically conductive media in the presence of molecular probes, including Bleomycin. The delivered electric pulses with a pulse duration range of 180-500 µs and a frequency range of 100-400 Hz had a low field intensity ranging from 1.5 V/cm to 7.3 V/cm. Spectrophotometric and spectrofluorometric measurements were used to investigate the impact of these variables on cancer cell survival and the molecular probe uptake induced by the electric pulses. An all-or-nothing response was observed above a specified threshold of electric field intensity of 4 V/cm. This threshold was unaffected by changes in repetition frequency or pulse duration. It was not a temperature effect that caused the molecular probe uptake to increase. When bipolar asymmetric electric pulses were applied just before electroporation, the effectiveness of the cytotoxic impact of bleomycin was increased from 80%, when employing electroporation pulses alone, to 100%.
Prevalence and Causes of Intrahepatic and Extrahepatic Bile Duct Obstruction among the Jaundiced Patients at Riyadh Hospitals Diagnosed by Ultrasound
Authors: Hassan Mahasin , Kaabi Sarah , Alqahtani Sahar , Sharahily Badryah , Almodayan Lamia , Alghanim Mona , Alqahtani Faten , Abdulsalam Ahmed , Hawesa Halima , Abdelgabar Zohida , Luttfi Ibrahim
Published: December 2022

The aim of this study was to assess the prevalence and causes of bile duct obstruction among patients with jaundice at the ultrasound departments in Riyadh hospitals. Methods and Results: The study included 525 records of jaundiced patients above 18 years old that were referred to the ultrasound department. Data were collected from PACS (Picture Archiving and Communication System) at three different hospitals in Riyadh. Of 525 adult jaundiced patients, 69 had biliary obstruction, a 13% prevalence. In our study, 38(55.1%) cases of obstruction were caused by stones, 14(20.3%) by tumors, 9(13.0%) by inflammation, 5(7.2%) by a nonfunctioning stent, and 3(4.3%) by pnemobilia. Obstructive jaundice occurred significantly more frequently with increasing age. The study revealed no significant difference between gender and the presence of obstruction. More studies with a larger sample size of obstructive jaundice patients are suggested.
Evaluations of Paranasal Sinus Disease Using Multidetector Computed Tomography in Taif City, Saudi Arabia
Authors: Alotaibi Osama , Osman Hamid , Hadi Yasser , Alzamil Yasser , Alyahyawi Amjad , Al-Enezi Mamdouh , Alafer Feras , Abanomy Ahmad , Khandaker Mayeen , Almeshari Meshari
Published: December 2022

Background: This study aimed to evaluate paranasal sinusitis disease and determine if there is a relationship between the anatomical variation of sinusitis based on the age and gender of the patient and, if so, to identify the most affected demographic group. Methods and Results: This study included 130 patients (76 men and 54 women with ages ranging from 18 years to 75 years) diagnosed with PNS disease and was conducted in the Radiology Department of King Abdelaziz Specialist Hospital and King Faisal Hospital (Taif city, Saudi Arabia) from January 1 2021 to January 31 2022. The evaluation of sinusitis was conducted using multidetector computed tomography. The clinical symptoms included 70% cases of nasal obstruction, 53% cases of headache, 28.5% cases of nasal discharge, 17.7% cases of facial pain, and 3.1% cases of general malaise. The types of sinusitis included maxillary sinusitis (88.5%), sphenoid sinusitis (28.5%), ethmoid sinusitis (43.8%), and frontal sinusitis (23.5%). The study found no significant anatomical variation of sinuses based on age and gender (P>0.05). Conclusion: An evaluation of paranasal sinusitis disease using an MDCT scan shows that there are no gender or age-related differences in the prevalence of the disease. Moreover, the study demonstrates that there is no significant anatomical variation of sinuses based on age and gender.
Resonant Actualization of Cultural Codes as a Determinant of Mental and Social Transformations (Part 2)
Authors: Kruglov, Alexander , Kruglov Andrey
Published: December 2022

The cumulation of cultural codes forms and structures the integral matrix of information capacity - the cognitive thesaurus (CT) of the psyche. The dissociation of the parameters of the current balance of somatic/mental homeostasis initiates a compensatory need. The "need" extracts from the CT (actualizes) the "image" of the cultural code - a representable informational equivalent of the "need" ("dominant"). Being the content of consciousness at the time of relevance, "dominant" acquires the properties of a resonant operator, a dominant focus, forming control mental constructs. Actualization of the "dominant" initiates the activity of the "action result acceptor." For the actual dominant, the "action result acceptor" is an indicator/corrector, a frequency matching censor (resonance): perceptual dynamics of operational images of external presentation ("code key") to the parameters of the "dominant" (code). Decoding the physical parameters of the "code" provides the potential to regulate the resonant impact on the arsenal of "cultural codes" of CT through moderation of the "code key." The CT, through the "action result acceptor" (the extra-conscious regulator of the actual autonoetic forms of mental activity), programs and formats the somatic/psychic continuum of the individual. The integral matrix of the CT, having a location outside the conscious sector of the psyche, including the imperative corrector of the perceived sector of the psyche associated with the emotional register, determining/correcting the main vectors of the regulation of the life continuum, is meaningfully close to the philosophical/psychological criteria of the main cognitive regulator of the person activity, defined as the soul.
Manipulation of Epigenome: Opportunities and Pitfalls in Fighting Autoimmune Diseases
Authors: Higazi Hassan , Khan Faheem , Ali Sara , Mohamed Salma , Pandupuspitasari Nuruliarizki , Yousif Ashraf , Kandakurti Praveen
Published: December 2022

Many recent studies have focused on the manipulation of the epigenome to understand the mechanistic programming in health and some disease phenotypes. These studies are designed to provide suitable drug targets to cure and/or prevent the outcome of a disease condition. Autoimmune diseases (ADs), including obesity and diabetes, are of major health concern nowadays and are the root cause of several diseases of the heart, lungs, and liver. There are several epigenetic mechanisms underlying the manifestation of autoimmune disorders. The recent advances in today’s sequencing technology and genome editing have uncovered the role of epigenetic modifications in ADs. In this review, we will cover the recent discoveries and their possible application in the control of ADs by improving the long-term use of such technologies. The potential drawbacks will also be discussed so that future experiments may be designed to reduce or eliminate the risk factors associated with the use of recent discoveries in the field of medicine.
New Concepts in Rosacea Classification and Treatment
Authors: Hussein Ramadan , Abdelbasset Walid
Published: December 2022

Rosacea is a chronic, persistent, inflammatory skin disease of the central face and eyes, caused by immune dysfunction and neurovascular dysregulation, that presents with recurrent flushing, erythema, telangiectasia, papules, or pustules. Recent research has linked rosacea to autoimmune, gastrointestinal, neurological, and psychiatric diseases and cancer risks. This review discusses the rosacea subtype-directed approach management, new topical and systemic formulations, and therapy combinations depending on new phenotype classification.
Novel Metformin Indications and Skin Disorders
Authors: Hussein Ramadan , Abdelbasset Walid , Osama Mahfouz Osama Mahfouz
Published: December 2022

Metformin is the first-line medication to increase insulin sensitivity in insulin-resistant conditions such as type 2 diabetes, polycystic ovary syndrome, and obesity. However, metformin is a drug with a wide range of pharmacological properties, showing the ability to treat various skin conditions. Some inflammatory skin dermatoses, skin neoplasms, endocrinology-related dermatosis, pigmentary disorders, skin aging, and wound healing have all shown improvement when metformin is used. This review discusses the most recent research supporting the use of metformin as a treatment for common skin conditions.
Wong, J., & Waring, H.Z. (2021). Conversation analysis and second language pedagogy: A guide for ESL/EFL teachers. Routledge.
Authors: Davey Michael
Published: December 2022

Conversation analysis and second language pedagogy: A guide for ESL/EFL teachers.
Wong, J., & Waring, H.Z. 
Routledge, 2021
Salaberry, M. R., & Burch, A. R. (Eds.) (2021). Assessing speaking in context: Expanding the construct and its applications
Authors: Zohali Leila
Published: December 2022

Assessing speaking in context: Expanding the construct and its applications
Salaberry, M. R., & Burch, A. R. (Eds.)
Multilingual Matters, 2021
Acknowledgement of Country
Authors: Journal Coordinator TESOL in Context
Published: December 2022

Acknowledgement of Country
In the spirit of reconciliation the Australian Council of TESOL Associations (ACTA) acknowledges the Traditional Custodians of country throughout Australia and their connections to land, sea and community. We pay our respect to their elders past and present and extend that respect to all Aboriginal and Torres Strait Islander peoples today. We acknowledge that the arrival of the English language to this continent impacted the traditional languages and cultures of Aboriginal and Torres Strait Islander people, and celebrate the work to reclaim or maintain these languages. ACTA members teach English in addition to supporting the maintenance and development of First Languages, and encourage the acquisition and use of other languages – including First Nations Languages.
Occupational-Related Shoulder and Neck Pain Among the Working Population of Ethiopia: Systematic Review and Meta-Analysis
Authors: Mengistu Dechasa Adare , Dammu Yohannes Mulugeta , Debelu Desi , Muche Liku , Mulat Salie , Berhanu Ashenafi , Muzeyin Mohammed , Ahmed Fila
Published: December 2022

Background: Currently, work-related musculoskeletal disorders are a significant public health concern and are one of the leading causes of disability-adjusted life years and reduced quality of life. Therefore, the current study aimed to determine the country-wide prevalence of work-related musculoskeletal disorders, particularly shoulder and neck pain, in Ethiopia.Methods: This study considered studies conducted in Ethiopia, written in English and published in 2017-2020 and searched using electronic databases such as PubMed/MEDLINE, Web of Science, Google Scholar, CINAHL, SCOPUS, Embase, African Index Medicus, and African Journals Online database. The quality assessment of the studies was done using Joanna Briggs Institute Critical Assessment tools to determine the relevance of each included article to the study.Results: The study found that the pooled prevalence of shoulder and neck pain in the previous year represented 37.9% [95% CI:26.5, 50.8%] and 29.9% [95% CI: 20.1, 41.9], respectively. Based on the subgroup analysis, the pooled prevalence of shoulder pain in the last year based on the study population, publication year and study region was 47.6% [95% CI: 45.8, 49.4%], 49.8% [95% CI: 45.7, 53.9%] and 44.6% [95% CI: 41.4, 47.8%], respectively, while the pooled prevalence of neck pain in the last year based on the study population, publication year and study area was 39.1% (95% CI: 37.5, 40.7%], 25.1% [ 95% CI: 20.8, 29.9%] and 32.6% [95% CI: 29.8, 35.5%], respectively.Conclusions This study found that at least one third of the study participants had experienced occupational-related shoulder and/or neck pain in the previous year. The study suggests that there is a need to implement occupational health and safety measure to reduce work-related musculoskeletal disorders and other hazards.
How do we Sustain Multidimensional Poverty Escape? Employing the Zero poverty Tripods
Evidence from Rural Ethiopia
Authors: Haile Dereje , Tsehay Abrham Seyoum , Bekele Alemu Azmeraw , Gebremaryam Haymanot Asfaw
Published: December 2022

Ending extreme multidimensional poverty needs three-pronged approaches of sustained escapes, stopping impoverishment of the vulnerable non-poor, and tackling chronic poverty. Using the Ethiopian Socioeconomic Survey data (2011/12–2015/16), this study attempted to explore the major options for eradicating multidimensional poverty. Multidimensional poverty is estimated using Alkire and Foster methodology. The study finds a moderate decline in multidimensional poverty through the change in the headcount than the intensity of deprivation. The findings suggest that multidimensional poverty needs to be interrupted by investments in infrastructure to improve market access, commercialization, and human capital formation. Hence, urbanization and rural livelihood transition deserve much more attention when striving for sustainable poverty alleviation. Moreover, institutional measures that enhance rural transformation would go a long way in creating the conditions that enable sustained multidimensional poverty escape and breaking the vicious cycle of subsistence and vulnerability of smallholder farming. Policies requiring more attention to enhance sustained escape from poverty are access to productive assets, commercialization, saving, wage labor participation, and promoting the rural non-farm economy to get to poverty zero. The need to foster growth from below is also the most vital solutions of creating the conditions that enable poor households to escape and then stay out of poverty. Equally important, impoverishment of the vulnerable non-poor needs to be protected by enhancing social protection, in the form of ex-ante insurance and post-shock safety nets, that would have substantial returns, not just in terms of the short-run welfare gains, but also in ways to meet long-term objectives.
Exploring Mental Health Outcome Variables in Outdoor Adventure Education
Authors: Davidson Curt , Ewert Alan
Published: December 2022

Background: The COVID-19 Pandemic has changed many facets of outdoor recreation. These changes have significantly impacted various outdoor adventure and experiential education (OAEE) programs.Purpose: Using past literature, four variables were thought to represent future and important student outcome variables for which OAEE programs should consider striving to impact. Accordingly, the purpose of this pilot study was to examine the effects of participation in an OAEE program and the impacts of coping with anxiety and uncertainty, depression, hopelessness, and enhancing resilience.Approach: This study used an online data collection software with a 30-item inventory to measure selected variables. Using a retrospective-pre design, data were collected and analyzed using repeated measuret-tests.Results:This study showed significant differences on anxiety, hopelessness, and resilience.Implications: Results suggest that OAEE programs can effectively enhance an individual's ability to cope with anxiety and hopelessness while enhancing their levels of resilience.
Multi-Fractal Detrended Cross-Correlation Heatmaps for Time Series Analysis
Authors: Junior Paulo Roberto de Melo Barros , Bunge Kianny Lopes , Rodrigues Vitor Hugo Serravalle  Reis , Santiago Michell Thompson Ferreira , Marinho Euler Bentes dos Santos , Silva Jose Luis Lima de Jesus
Published: December 2022

Complex systems in biology, climatology, medicine, and economy hold emergent properties such as non-linearity, adaptation, and self-organization. These emergent attributes can derive from large-scale relationships, connections, and interactive behavior despite not being apparent from their isolated components. It is possible to better comprehend complex systems by analyzing cross-correlations between time series. However, the accumulation of non-linear processes induces multiscale structures, therefore, a spectrum of power-law exponents (the fractal dimension) and distinct cyclical patterns. We propose the Multifractal Detrended Cross-Correlation Heatmaps (MF-DCCHM), a systematic approach representing a process with clear, defined, and repeatable steps to map the relationships between fluctuations of signals on different time scales and regimes. Our dataset is composed of sales and inventory from the Brazilian automotive sector and macroeconomic descriptors, namely the Gross Domestic Product (GDP) per capita, Nominal Exchange Rate (NER), and the Nominal Interest Rate (NIR) from the Central Bank of Brazil. Our results indicate cross-correlated patterns that can be directly compared with the power-law spectra for multiple regimes. We have also identified cyclical patterns of high intensities that coincide with the Brazilian presidential elections. The MF-DCCHM uncovers non-explicit cyclic patterns, quantifies the relations of two non-stationary signals (noise effect removed), and has outstanding potential for mapping cross-regime patterns in multiple domains.
Direct Admission Versus Interhospital Transfer for revascularisation in non-ST-Segment Elevation Myocardial Infarction
Authors: Steenbergen GJ van , Demandt JPA. , Schulz DN , Tonino PA , Dekker L , Vermeer-Gerritzen Iris , Wijnbergen IF , Thijssen HJM , Theunissen LJHJ , Heijmen HPCM , Haest RJP , Vlaar PJ , Veghel D
Published: December 2022

Objective We aim to compare quality parameters, costs and clinical outcomes of NSTEMI patients stratified by centre of first presentation and revascularisation strategy.
Methods Hospital claim data on patients admitted with a NSTEMI between 2017 and 2019 from one of the largest health insurers in the Netherlands were used for this study. Included patients were stratified by revascularisation strategy (PCI, CABG or no revascularisation [noRevasc]) and subdivided by centre of presentation per treatment. The primary outcomes were the following quality measures: duration between admission and revascularisation, length of hospital stay and number of intracoronary procedures. Total costs (accumulation of costs for hospital claims and inter-hospital ambulance rides) and clinical outcomes at 30 days (MACE: all-cause mortality, recurrent myocardial infarction and cardiac readmission) were used as secondary outcomes.
Results A total of 9641 NSTEMI events (9167 unique patients) were analysed for which PCI was performed during admission in 4448 cases, CABG in 816 cases and no revascularisation was performed in 4377 cases. Direct presentation at an intervention centre occurred in 59%, 55% and 60% of cases, respectively. For PCI, direct presentation at an intervention centre yielded shorter time to revascularisation, shorter hospitalisation and less intracoronary procedures per patient. For CABG, time to revascularisation and hospitalisation were shorter. Total costs were significantly lower in case of direct presentation in an intervention centre for all treatment groups while MACE was similar.
Conclusion Direct admission of NSTEMI patients to an intervention centre might yield improvement potential for current NSTEMI care.
Polymorphism of FEN1 Gene is Associated with DNA Damage of Cytb Gene in Arsenic-Exposed Workers
Authors: Xu Jie , Zhao Ruihuan , Jiang Jinjun , Ma He , Liu Na , Jiang Chenglan , Li Shuting , He Yuefeng
Published: December 2022

Objective: To explore the relationship between Polymorphism of FEN1 Gene and DNA Damage of Cytb Gene in Arsenic-Exposed Workers.
Methods: The content of arsenide in urine of 79 arsenic-exposed workers and 24 agricultural workers was detected by an atomic absorption spectrophotometer. The DNA damage level of Cytb gene and the polymorphism of FEN1 gene in peripheral blood were detected by polymerase chain reaction.
Results: The increased exposure to arsenic caused DNA damage of Cytb gene, resulting in an increase in the content of arsenide in urine and hypomethylation of arsenic metabolism. Meanwhile, there was a potential positive correlation between the FEN1 rs174538 AA or GA+AA allele and the DNA damage level of Cytb gene.
Conclusions: The DNA damage of Cytb gene caused by arsenic exposure is related to FEN1 gene polymorphism, the content of arsenide in urine and the level of arsenic methylation metabolism.
Psoas abscess in pregnancy - a review of the literature and suggestion of minimally invasive treatment options
Authors: Schröder Carolin , Calite Elina , Böckenhoff Paul , Büttner Thomas , Stein Johannes , Gembruch Ulrich , Strizek Brigitte
Published: December 2022

Aim: Less than a dozen cases of psoas abscesses in pregnancy have been described in the literature. We reviewed the literature when treating a patient with a psoas abscess after ipsilateral double J-ureteral stent placement (in the following: “double J-stent”) due to infected hydronephrosis.
Methods: In January 2022, this review was searched using the Pubmed/MEDLINE database and the mesh terms “Psoas Abscess” AND “Pregnancy”. Studies were included in any language and of all years, describing a psoas abscess during pregnancy. When patients did not have a psoas abscess, the abscess occurred after pregnancy, or when there was no full text available, the article was excluded.
Main Results: Ten case reports about patients with psoas abscesses during pregnancy were included. The classical symptomatic triad of psoas muscle abscess included lower back pain, limping and persistent fever with daily spikes. However, in most cases, not all three symptoms can be found. Especially, fever is absent in more than half of the patients. Psoas abscesses are described between 13 and 39 weeks of gestation. Primary psoas abscesses with haematogenous spread are more common during pregnancy than secondary with spread per continuitatem. In the literature, the main reasons for psoas abscess are spinal tuberculosis, drug abuse or underlying diseases such as Crohn’s disease. It is not uncommon for the definite cause to be unclear.
Regarding the patient's symptoms, pyelonephritis is often considered a possible aetiology. In general, the main treatment options include antibiotic treatment and abscess drainage. There is no higher caesarean section rate, and no negative outcome for the fetus has been described.
Case presentation: In our patient, a 38-year-old obese Caucasian woman, who had received a left double J-stent for infected hydronephrosis at 15 weeks of gestation, we successfully treated a psoas abscess of 20 x 10 cm with a sonographically assisted abscess drainage and antibiotics. The further course of pregnancy and the elective repeat caesarean section at 38 + 0 weeks of gestation were without any problems. Double J-stent placement and laser stone lithotripsy during puerperium were performed because of recurrent urolithiasis.
Conclusions: Although rare, psoas abscesses can occur during pregnancy, and it has often been treated surgically in the past. A psoas abscess as a complication after infected hydronephrosis and intervention during pregnancy has never been reported in the literature. Even for obese patients, minimally invasive therapy may be a treatment option that has rarely been reported in the literature.
Effects of Native and Particulate Polyphenols on Dna Damage and Cell Viability After UV-C Exposure
Authors: Potapovich Alla I. , Kostyuk Tatyana V. , Ishutina Olga V. , Shutava Tatsiana G. , Kostyuk Vladimir A.
Published: December 2022

Background
plant polyphenols have poor water solubility, resulting in low bioavailability. In order to overcome this limitation, the drug molecules can be coated with multiple layers of polymeric materials.
Methods
microcrystals of quercetin and resveratrol coated with a (PAH/PSS)4 or (CH/DexS)4 shell were prepared using the layer-by-layer assembly method; cultured human HaCaT keratinocytes were treated with UV-C and after that cells were incubated with native and particulate polyphenols. DNA damage, cell viability and integrity, were evaluated by comet-assay, using PrestoBlueTM reagent and lactate dehydrogenase (LDH) leakage test.
Results
the data obtained indicate that: both native and particulate polyphenols added immediately after UV-C exposure increased cell viability in a dose-dependent manner, however the efficiency of particulate polyphenols was more pronounced; quercetin coated with a (PAH/PSS)4 or (CH/DexS)4 shell more effectively than the native compound reduced the number of single-strand DNA breaks in the nuclei of keratinocytes exposed to UV-C radiation; native and particulate resveratrol were ineffective against DNA damage.
Conclusion
quercetin reduces cell death caused by UV-C radiation and increase DNA repair capacity. Coating quercetin with (PAH/PSS)4 or (CH/DexS)4 markedly enhanced its impact on DNA repair probably by facilitating transport into the nucleus.
Comparative genetic and epigenetic of the Wedelia trilobata (L.) from different regions
Authors: Xiao Yusha , chen Xiuqing , Ying yuhan , Zheng jiening , Yi Huixian , Song Liying
Published: December 2022

Background
Wedelia trilobata (L.) Hitchc., is a common and widespread invasive plant in South China. In order to further explore the molecular mechanisms of its rapid adaptation, we selected DNA methylation-sensitive amplified polymorphism (MSAP) and simple sequence repeats (SSR) to analyze 60 W. trilobata individuals from Fuzhou (FZ), Haikou (HK), Jinghong (JH) and Guangzhou (GZ).
Results
In this study,The Shannon diversity index (I) of SSR and MSAP Nei are 0.236, 0.184; the average methylation rate of W. trilobata from the four regions is 18.25% − 32.92%, indicating that W. trilobata is highly methylated. In the unweighted pair group method with an arithmetic mean (UPGMA) phylogenetic tree, all populations in the MSAP are clustered together. The geographical distance between HK and JH is the closest, and GZ is the farthest from the other three populations. Epigenetic distance is more susceptible to geographical distance, as the correlation between epigenetic distance and geographical distance is significantly higher than that between genetic distance and geographical distance by Mantel analysis.
Conclusions
The result reveal that W. trilobata populations in different regions have high genetic and epigenetic diversity, as well as high methylation levels, in which epigenetic mechanisms play a stronger role.
RIPK3 Promotes Hantaviral Replication by Restricting JAK-STAT Signaling but not Triggering Necroptosis.
Authors: Ma Hongwei , Si Yue , Zhang Haijun , Zhou Ziqing , Zhu Xudong , Yang Yongheng , Liu He , Zhang Liang , Cheng Linfeng , Wang Kerong , Ye Wei , Lv Xin , Zhang Xijing , Hou Wugang , Zhao Gang , Lei Yingfeng , Zhang Fanglin
Published: December 2022

Hantaan virus (HTNV) is a rodent-borne virus that can cause hemorrhagic fever with renal syndrome (HFRS) with a case fatality rate of 15% and is listed as a re-emerging infectious disease (REID) in China. At present, no specific therapeutic strategies against HTNV are available. Interferon (IFN) is a crucial antiviral molecular which can trigger interferon-stimulated genes (ISGs) expression through the Janus kinase-signal transducer and activator of transcription 1 (JAK-STAT) pathway. Large quantities of IFN produced at the late stage of HTNV infection could not effectively restrain viral replication, the mechanism of which is still unclear. Here, we identified the receptor-interacting protein kinase 3 (RIPK3), a critical molecular to mediate necroptosis, could facilitate HTNV infection by blocking JAK/STAT signaling. HTNV infection promoted the total expression level of RIPK3, but not the phosphorylation of RIPK3, thus not leading to cell death. RIPK3 ablation could restrain HTNV replication by enhancing the expression of multiple ISGs, during which the type I IFN generation did not strengthened. Exogenously expressing RIPK3 might hinder the host anti-hantaviral responses. RIPK3−/− mice also maintained a robust ability to clear HTNV promptly with enhanced innate immune responses. Mechanistically, RIPK3 restricted STAT1 activation by bonding to STAT1 and blocking its phosphorylation sites, hence interfering with host IFN responses. Overall, these observations demonstrated a noncanonical function of RIPK3 during viral infection, and shed light on the novel evasion strategy of host innate immunity by HTNV.
VOCs species controlling O3 formation in ambient air and their sources in Kaifeng, China
Authors: Chen Yijia , Shi Yuqi , Ren Jie , You Guiying , Zheng Xudong , Liang Yue , Simayi Maimaiti , Hao Yufang , Xie Shaodong
Published: December 2022

The concentration of ozone has been in a rising crescendo in the last decade while the fine particles (PM2.5) is gradually decreasing but still at a high level in central China. Volatile organic compounds (VOCs) are the vital precursors of ozone and PM2.5. A total of 101 VOC species were measured in four seasons at five sites from 2019 to 2021 in Kaifeng. VOC sources and geographic origin of sources were identified by the positive matrix factorization (PMF) model and the HYbrid Single-Particle Lagrangian Integrated Trajectory transport model. The source-specific OH loss rates (LOH) and ozone formation potential (OFP) were calculated to estimate the effects of each VOC source. The average mixing ratios of total VOCs (TVOC) were 43.15 parts per billion (ppb), of which the alkanes, alkenes, aromatics, halocarbons, and oxygenated VOCs respectively accounted for 49%, 12%, 11%, 14%, and 14%. Although the mixing ratios of alkenes were comparatively low, they played a dominant role in the LOH and OFP, especially ethene (0.55 s− 1, 7%; 27.11 µg/m3, 10%) and 1,3-butadiene (0.74 s− 1, 10%; 12.52 µg/m3, 5%). The vehicle-related source which emitted considerable alkenes ranked as the foremost contributing factor (21%). Biomass burning was probably influenced by other cities in the western and southern Henan and other provinces, Shandong and Hebei.