bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLIKASI KEPPRES NO.12 TAHUN 2020 PADA PERUSAHAAN PEMBIAYAAN
Authors: Siombo Marhaeni Ria , Waluyo Adi Emmanuel Ariananto
Published: December 2020

Perjanjian berisi tentang hak dan kewajiban para pihak dalam melakukan prestasinya masing-masing.  Jika salah satu pihak tidak melakukan prestasi maka dianggap melakukan wanprestasi. Namun, ada excuse sebagaimana diatur dalam Pasal 1245 KUHPerdata.  Wabah Covid-19 ditetapkan sebagai bencana nasional non-alam sebagaimana ditetapkan dalam Keppres No. 12 Tahun 2020, sangat berdampak luas termasuk lingkup perusahaan pembiayaan, yang mengakibatkan banyak debitur mengalami gagal bayar. Subtansi pengaturan dalam Keppres No.12 Tahun 2020 relevan dengan Pasal 1244 dan Pasal 1245 KUHPerdata. Sehingga diketahui bahwa debitur yang mengalami gagal bayar karena kondisi yang disebabkan oleh Covid-19 bukan merupakan wanprestasi. Namun demikian, itikad baik (Pasal 1338 ayat 3) dan prinsip kepatutan (Pasal 1339) KUHPerdata, harus mendasari penerapan Pasal 1245. Implikasi ditetapkannya Keppres No. 12 Tahun 2020 sudah selayaknya para debitur yang gagal bayar mendapatkan relaksasi, keringanan pembayaran dengan membebaskan dari pembayaran bunga, sebagaimana bunyi pasal 1245 KUHPerdata.
Identifikasi Ekstasi/MDMA Menggunakan Analisis Tes Warna dan Gas Chromatography-Mass Spectrometry (GCMS)
Authors: Rahayu Yunita Suci , Astuti Yayuk , Prasetya Eko Fery
Published: December 2020

MDMA (3,4-Methilendioxymethamphetamine) atau sering dikenal ekstasi yaitu senyawa turunan amfetamin yang dapat menyebabkan rasa senang berlebihan dan biasanya banyak digunakan pada festival musik dansa atau diskotik. Penggunaan MDMA dapat memepengaruhi resiko kesehatan yang serius diantaranya dalam jangka pendek menyebabkan  hipertermia, kejang, aritmia, hiponatremia, rhabdomiolisis dan kerusakan jangka panjang pada sistem saraf pusat. Salah satu metode untuk mengidentifikasi adanya senyawa MDMA yaitu menggunakan tes warna dan GCMS “Gas Chromatography-Mass Spectrometry”. Uji tes warna merupakan uji screening untuk mengatahui ada tidaknya senyawa MDMA dalam sampel dengan menggunakan reagen marquis. Sedangkan GCMS yaitu instrumen yang dapat digunakan untuk mengetahui kandungan suatu senyawa dalam sampel dengan membandingkan waktu retensi antara senyawa yang belum diketahui dengan waktu retensi referensi. Pada penelitian ini, penulis melakukan identifikasi barang bukti tablet menggunakan analisis tes warna dan GCMS. Hasil yang diperoleh pada uji tes warna yaitu terjadi perubahan warna dari merah menjadi hitam. Kemudian dilakukan uji konfirmatif menggunakan metode GCMS. Hasil yang diperoleh yaitu pada spektra GC terdapat dua puncak yang menonjol yaitu MDMA dan kafein dengan waktu retensi berturut-turut yaitu 10,875 menit dan 13,341 menit. Hasil ini sesuai dengan Library W10N11. Berdasarkan hasil pengujian tersebut, dapat disimpulkan bahwa sampel barang bukti tablet merah merupakan psikotropika golongan 1 yaitu ekstasi/ MDMA.
Hubungan Hasil Belajar Kalkulus Diferensial dan Kalkulus Integral Terhadap Hasil Belajar Kalkulus Lanjut Mahasiswa Pendidikan Matematika Universitas Sanata Dharma
Authors: Silvia Silvia , Fernandez Yohana Zettirareska , Limbong Yulvani Anggraeni Christine
Published: December 2020

Mata kuliah Kalkulus Lanjut di program studi Pendidikan Matematika Universitas Sanata Dharma (USD) dapat ditempuh mahasiswa dengan syarat telah lulus dari mata kuliah Kalkulus Diferensial dan Kalkulus Integral. Tujuan dari penelitian ini untuk menguji signifikansi kontribusi kemampuan Kalkulus Diferensial atau Kalkulus Integral terhadap hasil belajar Kalkulus Lanjut pada mahasiswa Pendidikan Matematika USD. Populasi pada penelitian ini adalah mahasiswa Program Studi Pendidikan Matematika USD. Sampel pada penelitian ini adalah mahasiswa Program Studi Pendidikan Matematika USD angkatan 2017 dengan teknik pengambilan sampel menggunakan cluster sampling. Teknik pengumpulan data dengan menggunakan dokumentasi. Teknik analisis data menggunakan uji regresi linier berganda dan uji korelasi. Seluruh analisis statistik dilakukan dengan menggunakan software SPSS. Berdasarkan hasil analisis data tersebut, disimpulkan ada kontribusi  yang signifikan antara hasil belajar Kalkulus Diferensial atau hasil belajar Kalkulus Integral terhadap hasil belajar Kalkulus Lanjut. Selain itu, hasil belajar Kalkulus Integral memiliki pengaruh atau kontribusi yang lebih domain terhadap hasil belajar Kalkulus Lanjut dari pada hasil belajar Kalkulus Diferensial dan terdapat error yang cukup besar yakni sebesar 46.7% sehingga menunjukkan ada pengaruh yang besar di luar hasil belajar Kalkulus Diferensial dan hasil belajar Kalkulus Integral. Hal ini didukung dengan hasil angket yang memperoleh bahwa ada faktor lain seperti dosen memberi pengaruh yang besar dalam hasil belajarnya.
How to Save Utopia? Aleksandr Beliaev’s tergiversations between science and entertainment
Authors:   University of Geneva, Morard Annick
Published: December 2020

How to Save Utopia? Aleksandr Beliaev’s tergiversations between science and entertainment Aleksandr Beliaev engaged a fruitful dialogue between several cultural fields, namely science, entertainment and fiction, and highlighted the imbrication of utopian discourses in the particular context of the implementation of the soviet project. He explored life sciences – that is to say, fields directly related to the human body, at least in five texts: Prof. Dowell’s Head (1925; 1937), Amphibian-Man (1928; 1938), Ariel (1941) and two lesser-known and less analysed short stories called Amba (1929) and its sequel Khoiti Toiti (1930). All these texts also have in common to engage a reflection on the cultural meaning of «extraordinary bodies» at the beginning of the 20th century. For this reason, this paper will focus on the triangulation between science, literature and entertainment; and assume that the world of entertainment constituted for Beliaev an escape hatch, a temporary way out, when he realized that science and scholars could no longer fulfill his own utopian ambitions.
The Risks of Associated Use of Alcohool and Tabaco: A Functional Learning and Its Limits
Authors: Bonnin-Scaon Sylvie , Chasseigne Gérard
Published: December 2020

Drinking alcohol and smoking tobacco commonly occur together. Young adults, middleaged adults, elderly people, and very elderly people perceive the combined effects on health of drinking and smoking as sub-additive. This model bears little resemblance to what is expected on the basis of epidemiological studies. The health risks of combining drinking and smoking, particularly the risk of cancer is multiplicative. This article reviews studies showing that learning the multiplicative relationship between daily intakes of alcohol and tobacco, and the risk of esophageal cancer is effective, even in 75 aged people, provided that participants receive outcome feedback through functional learning. This learning persists at least one month. This learning has limitations due to the decline of executive functioning that is associated with aging. The very old people have difficulty in learning the multiplicative rule. Instead, they learn an additive rule. Other studies are required. Because of the nature of the risks for esophageal cancer, specific groups should be targeted, those who drink and smoke heavily, and for whom esophageal cancer looms as an important personal threat.
THE INFLUENCE OF RETURN ON ASSETS, DEBT TO ASSETS RATIO AND CURRENT RATIO ON FINANCIAL DISTRESS
Authors: Rosi Nandias Alfiana , Hasanuh Nanu -
Published: December 2020

This study aimed to find out the influence of Return On Assets, Debt to Assets Ratioand Current Ratiopartially and simultaneously on Financial Distress. The data collection was conducted from annual report from five cosmetic and household companies listed in Indonesia Stock Exchange in 2013 – 2018. The data were analyzed through hypotheses test and classical assumption test using multiple  linear regression.  The result of partially test in this research, it indicated  that Return On Assets and Debt to Assets Ratio has influence on financial distress while the Current Ratio do not have influence on Financial Distress. The simultaneously result, Return On Assets, Debt to Assets Ratio and Current Ratio have influence on Financial Distress.

 

Keywords: Financial Distress; Return on Assets; Debt to Assets Ratio; Current Ratio.
PENGARUH SOCIAL MEDIA MARKETING TERHADAP BRAND AWARENESS DAN PURCHASE INTENTION (Studi Kasus : SMK Kesehatan Sanjiwani Gianyar)
Authors: Putra I Dewa Putu Gede Wiyata , Aristana Made Dona Wahyu
Published: December 2020

This study examined influence of social media marketing on brand awareness and purchase intention. SMK Kesehatan Sanjiwani Gianyar conducts social media marketing through paid promotions on Instagram and Facebook to increase brand awareness and interest of junior high school students to attend SMK Kesehatan Sanjiwani Gianyar. Data of 2017-2019 shows a decrease in the number of students, even though paid promotions have been carried out through Facebook and Instagram. Method in this study was Structural Equation Modeling (SEM) with the PLS Sample in this research was 100 junior high school students in areas Gianyar, Denpasar, Bangli, Klungkung and Badung regencies. Results in this study shows that social media marketing doesn’t have a significant effect on purchase intention. Social media marketing through paid promotions on Instagram and Facebook creates brand awareness. Increase purchase intention the school must convince the public that school has good quality by exploring the excellence and uniqueness of the school.
Continuous Glucose Monitoring for Underserved and Minority Patients with Type 2 Diabetes in an Interprofessional Internal Medicine Clinic
Authors: Bui Arden , Kim Jennifer
Published: December 2020

Objective: Evaluate the impact of interprofessional continuous glucose monitoring (CGM) on glycemic control in underserved and minority patients with type 2 diabetes mellitus (T2DM)
Methods: The IRB-approved, retrospective quasi-experimental study was conducted between August 2018 and August 2019 at an internal medicine residency clinic. Adult patients with diagnosed T2DM, an indication for CGM (hyperglycemia, hypoglycemia, and/or glycemic variability), and at least 10 consecutive days of CGM data were included. Patients who were pregnant and/or missed one or more clinic appointments were excluded. Patients were followed weekly over a 14-day period during which data from the CGM sensor were downloaded and interpreted by the interprofessional team. Interventions with shared decision-making were made at each visit.
Results: Fifty-five patients were included, with a mean age of 61+11.2 years, 86% were of non-white race, and 56% were female. Average blood glucose levels decreased from 208.39 mg/dL at week 1 to 190.74 mg/dL at week 2, a 17.65 mg/dL reduction (p = 0.0281). Time within target range (70-180 mg/dL) increased by 6.16% (p = 0.0038), while time above range (>180 mg/dL) decreased by 5.5% (p = 0.0168). Average number of hypoglycemic events (readings <70 mg/dL) did not change significantly from week 1 to week 2 (2.94 vs. 3.64, p > 0.05). Of the 66 interventions made after week 1, 33% were made by the pharmacy team, 56% were made by the attending or resident physicians, and 11% were made by the dietician. Of 59 interventions made after week 2, 32% were made by the pharmacy team, 49% were made by the attending or resident physicians, and 19% were made by the dietician.
Conclusions: The interprofessional collaborative CGM service was associated with improvements in glucose control based on increased time within target range and reduced hyperglycemia, without increasing the risk of hypoglycemia or medication burden.
Pengaruh Perbandingan Rumput Laut dan Susu Terhadap Karakteristik Yoghurt Probiotik Rumput Laut
Authors:   Universitas Padjadjaran, Sukarminah E , Cahyana Y ,   Universitas Padjadjaran, Rialita T ,   Universitas Padjadjaran, Yudiastuti Silvia Oktavia N ,   Politeknik Negeri Jember, Sobarsa H G ,   Universitas Jember
Published: December 2020

Yogurt probiotik rumput laut adalah produk makanan fermentasi bakteri asam laktat yang menggunakan susu dan rumput laut merah Eucheuma cottonii sebagai bahan bakunya. Rumput laut memberikan efek fungsional pada inang dan berdampak pada tekstur yogurt. Penelitian ini bertujuan untuk mengetahui rumusan keseimbangan rumput laut dan susu skim yang mempengaruhi karakteristik yoghurt untuk disukai oleh panelis. Metode penelitian yang digunakan adalah metode eksperimen menggunakan analisis rancangan acak kelompok dengan 5 perlakuan dan 3 ulangan. perlakuan yang diberikan adalah formulasi keseimbangan antara rumput laut dan susu 5:95, 15:85, 25:75, 35:65, dan 45:55 (v / v). keseimbangan Yogurt rumput laut dan susu 25:75 (v / v) memberikan karakteristik yogurt terbaik dengan pH 4,21; total padatan terlarut 16,75 brix; viskositas 765,67 mPas; total asam titrasi 0,64%; total bakteri asam laktat 6,9x108 cfu / mL; total bakteri probiotik 2,9 x 108 cfu / mL; kandungan protein 3,03%; 2,2% dari kandungan serat makanan dan karakteristik organoleptik yang meliputi warna 3,91% (suka), aroma 3,73 (suka), rasa 3,11 (biasa), ketebalan 3,6 (suka), keasaman 3,22 (normal), tekstur 3,45 (biasa), tekstur 3,45 (biasa) dan penampilan keseluruhan 3,64 (Suka).
Evaluasi Penggunaan Antibiotik Empiris dan Analisis Biaya Demam Tifoid di Sebuah RS Swasta Kota Semarang
Authors: Hanifah Hananun Zharfa , Sari Ika Puspita , Nuryastuti Titik
Published: December 2020

Demam tifoid disebabkan bakteri Salmonella typhi dimana dalam terapi memerlukan pemakaian antibiotik yang bijaksana secara rasional. Pemakaian antibiotik irasional dapat meningkatkan mortalitas, morbiditas, penyebaran penyakit dan biaya kesehatan. Penelitian ini bertujuan untuk mengetahui profil kesesuaian penggunaan antibiotik di sebuah RS Swasta Kota Semarang serta mengetahui hubungan antara rasionalitas penggunaan antibiotik terhadap biaya. Penelitian ini merupakan penelitian observasional menggunakan metode cross sectional dengan pengambilan data secara retrospektif. Analisis biaya dilakukan dengan menggunakan tipe farmakoekonomi Cost of Analsis (COI) berdasarkan pendekatan kejadian. Data diperoleh dari rekam medis dan faktur rekap keuangan sesuai kriteria inklusi penelitian. Data biaya yang digunakan merupakan data yang didapat dari perspektif rumah sakit. Analisis yang dilakukan adalah analisis deskriptif, rasionalitas antibiotik dengan metode Gyssens sedangkan analisis hubungan antara rasionalitas dengan biaya menggunakan uji statistika Mann Whitney. Hasil penelitian terdapat 180 kasus dengan 98 regimen antibiotik di bangsal dan 82 regimen antibiotik obat pulang. Persentase rasionalitas penggunaan antibiotik di bangsal sebesar 20,4% rasional dan 79,6% tidak rasional sedangkan rasionalitas regimen antibiotik pulang yaitu sebesar 7,3% rasional dan 92,7% tidak rasional. Ketidakrasionalan didominasi kategori IV A dan III B. Hasil analisis menunjukkan terdapat hubungan antara rasionalitas terhadap biaya antibiotik (p<0,05).
Dispersi Padat Asam Usnat dengan Teknik Freeze Drying menggunakan Poloxamer 188 sebagai Polimer
Authors: Noviza Deni , Fitriani Lili , Fauzi Riana Zikra
Published: December 2020

Tujuan dari penelitian ini adalah untuk meningkatkan kelarutan dari asam usnat yang memiliki kelarutan rendah di dalam air dengan menggunakan metode solid dispersi. Metode solid dispersi yang digunakan adalah teknik freeze drying dengan menggunakan poloxamer 188 sebagai polimer. Karakteristik dispersi padat yang terbentuk dilakukan dengan analisis difraksi sinar-X (XRD), Fourier Transform Infra Red (FTIR), Scanning Electron Microscopy (SEM). Lebih lanjut, penetapan kadar, uji kelarutan dan profil disolusi dilakukan dengan menggunakan asam usnat murni dan campuran fisik sebagai pembanding. Dari hasil XRD dan SEM menunjukkan bahwa asam usnat terdispersi dalam poloxamer dalam bentuk amorf.  Hasil FTIR menunjukkan asam usnat membentuk ikatan hidrogen dengan poloxamer 188. Hasil uji kelarutan menunjukkan kelarutan dispersi padat 1:1; 1:2; 2:1 (5,80 µg/ml; 6,94 µg/ml; 4,88 µg/ml) lebih tinggi dibandingkan campuran fisik 1:1 (0,39 µg/ml) dan asam usnat murni memiliki kelarutan yang paling rendah (0,34 µg/ml). Kesimpulannya dispersi padat dengan menggunakan poloxamer 188 dengan menggunakan teknik freeze drying dapat meningkatkan kelarutan dari asam usnat.
Eficiencia de la biodegradación de hidrocarburos de petróleo por hongos filamentosos aislados de suelo contaminado
Authors: Contreras Hans , Carreño Carmen
Published: December 2020

La biodegradación disminuye el impacto ambiental negativo de los derrames de hidrocarburos de petróleo. El objetivo de esta investigación fue determinar la eficiencia de biodegradación de hidrocarburos de petróleo de diez cultivos de hongos filamentosos hidrocarbonoclásticos seleccionados. Las muestras de suelo contaminado con hidrocarburos de petróleo presentaron concentración de hidrocarburos totales (HTP) (25 987 mg kg-1), microorganismos totales (>1,1 x 107 NMP g-1) microorganismos hidrocarbonoclásticos (1,1 x 106 NMP g-1) y un
nivel de toxicidad severo en el índice de germinación de Raphanus sativus L. “rabanito”. Los hongos filamentosos se aislaron en agar Bushnell Haas–petróleo 1%, obteniéndose 221 aislados, identificándose 14 géneros: Cunninghamella, Penicillium, Paecilomyces, Rhizopus, Syncephalastrum, Periconia, Fusarium, Bipolaris, Monilia, Cladosporium, Gliocladium, Aspergillus, Memnoniella y Helminthosporium. Todos losgéneros a excepción de Helminthosporium demostraron ser hidrocarbonoclásticos y se seleccionaron aquellos que alcanzaron los mayores valores de biomasa (1,00 a 1,95 g). En el suelo tratado con Aspergillus sp. HP-031 se alcanzó el mayor índice de germinación desde los 60 días, la disminución de la toxicidad a un nivel bajo a los 90 días y la mayor eficiencia (73%) en la degradación del HTP, demostrándose elpotencial de este hongo para labiorremediación.
Valoración económica del daño ocasionado por el incendio Área de Conservación Privada “Milpuj - La Heredad”, Magdalena, Amazonas
Authors: Casiano Inga Carlos Alberto , Guzmán Castillo Wagner , Campos Trigoso Jonathan Alberto
Published: December 2020

Los ecosistemas de bosque seco forman parte de los valles interandinos del noreste de Perú, y son considerados como una de las fronteras biogeográficas más importante de los Andes, que alberga especies endémicas de flora y fauna. Sin embargo, debido a la presión antrópica, como la quema para ampliar la frontera agrícola y ganadera, tala, cacería, invasiones, etc.; estos ecosistemas están siendo reducidos y amenazados, y por ende, los servicios ecosistémicos que brindan. Por lo cual, a pesar de los esfuerzos de titulares privados por invertir en la conservación de la diversidad biológica a través de modelos de aprovechamiento sostenible y la restauración de los mismos, aún se evidencia la desvinculación del cuidado de la biodiversidad de terceras personas, que constantemente atentan contra estos espacios. En consecuencia, se propone la valoración económica de los daños a los recursos naturales para cuantificar los daños y perjuicios causados sobre los valores de uso y no uso, en términos monetarios, para la compensación adecuada, por las pérdidas en recursos productivos y/o por gastos de limpieza y restauración del área, debido al incendio ocasionado en el ACP Milpuj – La Heredad. El análisis del valor económico del daño se hizo a través de la suma de los costos del daño, costos de las medidas de restauración y del valor económico de los servicios ecosistémicos del bosque seco; obteniendo la cantidad total de S/. 210, 279. 67, y S/. 8,963.33/ha.
Caracterización de los sistemas de producción de ganado bovino en las cuencas ganaderas de Ventilla, Florida y Leyva -región Amazonas
Authors: Murga Luis , Vásquez Héctor , Bardales Joseph
Published: December 2020

Con el objetivo de caracterizar los sistemas de producción de bovinos en las cuencas ganaderas de Molinopampa y Olleros en la provincia de Chachapoyas, Yambrasbamba y Florida en la provincia de Bongará, Huambo y Limabamba en la provincia de Rodríguez de Mendoza - región Amazonas. Se aplicó una encuesta a 143 ganaderos, comprendiendo los rubros sociales, económicos, técnicos y de producción. Los datos se ordenaron en una matriz de datos y se procesaron en software SPSS versión 17, mediante estadística descriptiva. Los resultados evidenciaron que la mayor parte de los productores fueron partidarios del manejo con limitada tecnología, y solo una minoría opta por técnicas medianamente actualizadas e incompletas. De los encuestados, 36% tiene título de propiedad, 18 % utilizan registros de producción, presentando un sistema semi-intensivo de crianza, con alimentación a base de pastos de corte, pastos mejorados y algunos ganaderos utilizan otros alimentos terminados, con limitada infraestructura ganadera. La comercialización de la leche es a través de la empresa Gloria, microempresas y mercados informales. En general, se encontró debilidades como la falta de infraestructura y equipo adecuado, por lo que es necesario la intervención de los actores del desarrollo agropecuario, para mejorar la actividad ganadera y hacerla más competitiva.
Localización óptima de un relleno sanitario empleando sistemas de información geográfica distrito de Chachapoyas Amazonas- 2017
Authors: Espejo Pingus Angers William
Published: December 2020

La presente investigación surge como una alternativa a los problemas socio ambientales que se generaron en el proyecto SNIP - 146148 “Mejoramiento y ampliación de la gestión integral de los residuos sólidos municipales del distrito de Chachapoyas, provincia de Chachapoyas, región Amazonas ", específicamente los impactos del estudio de selección de sitio para la disposición final de residuos sólidos en la ciudad de Chachapoyas, sobre el suelo, aire, agua y la vulneración de los derechos fundamentales. El objetivo fue localizar una área óptima (técnica y ambientalmente adecuada) para un relleno sanitario empleando un sistema de información geográfica - SIG, integrado a los criterios de selección de sitio como pendiente, geología, distancia a carreteras, hidrología, bosques, distancia a la población urbana - rural, distancia a un aeropuerto y el volumen de almacenamiento, estos criterios se evaluaron mediante la evaluación multicriterio y los pesos para cada criterio fueron de 0 para lugares no óptimos y 1 para lugares óptimos, empleando los SIG se obtuvieron cuatro zonas óptimas dentro del área de estudio, cada uno de ellas con sus áreas correspondientes: Área 01 = 60.43 Has., Área 02 = 6.91 Has., Área 03 = 3.1 Has., y Área 04 = 15.1 Has. La metodología utilizada tuvo una fase de campo, en la cual la recopilación de información y la toma de puntos de control con GPS fue in situ, y en la fase de gabinete se determinaron la caracterización de la gestión de los residuos sólidos, los criterios de selección de sitio, la elaboración de los mapas temáticos, la  superposición de mapas y posteriormente el análisis e interpretación. El distrito de Chachapoyas cuenta con una población de 23399 habitantes según la tasa de crecimiento de la población. Mientras que se estima que en el año 2025 la población sea de 30275 habitantes, a medida que la población y la urbanización aumenta, el consumo aumenta y con ello los residuos sólidos es un gran problema para la gestión municipal, por lo tanto, elegir el sitio óptimo para un relleno sanitario es muy crucial.
Propagación in vitro de babaco (Vasconcellea x heilbornii) del distrito de Luya, región Amazonas
Authors: Millones Chanamé Carlos
Published: December 2020

La presente investigación se realizó con el objetivo de desarrollar un protocolo para el establecimiento y ensayos preliminares de propagación in vitro de babaco (V. x heilbornii) proveniente del distrito de Luya, región Amazonas. Se recolectaron secciones vegetativas de plantas de V. x heilbornii, evaluando desinfectantes como lejía comercial y cloruro de mercurio para el establecimiento de yemas axilares, posteriormente se evaluó diferentes concentraciones de reguladores de crecimiento auxinas, giberelinas y citocininas en la propagación in vitro de V. x heilbornii. Los resultados mostraron que el empleo de una combinación de lejía comercial al 10% más cloruro de mercurio 0,1% fueron los adecuados para la asepsia de las secciones vegetativas de V. x heilbornii. En tanto, el empleo de AIA 0,5 mg/L más 2iP 1- 2 mg/L permitieron el crecimiento y desarrollo de yemas axilares, resultados que permitirán la propagación in vitro de esta especie silvestre de importancia económica.
POVIX: Una interfaz gráfica de usuario (GUI) en MatLab para calcular el polinomio de Villarreal
Authors: Quiñones Huatangari Lenin , Milla Pino Manuel Emilio , Damián Sandoval Leonardo
Published: December 2020

El matemático peruano Federico Villarreal en 1879 propuso una fórmula para calcular la potencia n-ésima de un polinomio P(x), denominado Polinomio de Villarreal. El objetivo del presente trabajo fue crear una interfaz gráfica para usuario que nos permita calcular la potencia n-ésima entera de un polinomio, a partir de la fórmula propuesta por el científico. Para ello se utilizó la herramienta matemática MatLab v9.2 (R2017a) sobre el sistema operativo Windows 10. Con ayuda del Toolbox GUIDE (Graphical User Interface Development Environment) se diseñó la GUI basada en la fórmula propuesta por Villarreal. Además, con MatLab Compiler™ v9.01, se obtuvo una aplicación autónoma, capaz de ejecutarse en cualquier computadora que tenga una distribución de Windows 10. El resultado obtenido del presente trabajo fue la interfaz gráfica para usuario denonimada POVIX, la cual los resultados que estima son los mismos que se ha obtenido por otros métodos analíticos.
Modern state of enforcement of economic crimes committed by organized groups and criminal organizations
Authors: Mangasarov Ruslan Anatol'evich , Khannanov Radmil Rafkatovich
Published: December 2020

The research object is the criminogenic aspects of the economic situation in the Russian Federation. The research subject includes the patterns and tendencies of emergence and development of economic crime in the Russian Federation; criminal legal prohibitions of wrongful deeds in the economic field; law enforcement practice of struggle against economic crimes committed by organized groups and criminal organizations.   The purpose of the research is the development of scientifically-grounded suggestions and recommendations aimed at raising the effectiveness of  enforcement of economic crimes committed by organized groups and criminal organizations.  The research methods include content-analysis of documents, analysis, synthesis, description and comparison. The scientific novelty of the research consists in the theoretical analysis of the essence of struggle against economic crimes committed by organized groups and criminal organizations. Some other provisions of the article are remarkable for their scientific novelty, particularly: a) the authors outline the features of modern organized criminal groups and criminal organizations; b) the authors define the main directions of criminal aspirations of organized criminal groups in the economic field; c) the authors outline the methods of economic crimes committing used by organized groups and criminal organizations.    The key findings of the article are: based on the established tendencies and patterns, the authors believe that the main directions of the further improvement of internal affairs bodies’ activities, particularly the investigation activities of economic security and anti-corruption enforcement units, in the field under consideration, will be the improvement of the work of specialized internal affairs units and their involvement in solving the tasks of struggle against economic crimes committed by organized groups and criminal organizations by means of subversive operations against economic and financial grounds of criminal organizations and their corrupt connections, and by means of effective information and analytical work, prognostication, planning, internal and external interaction.   
Criminal law principles with double prevention: a concept and a preventive action mechanism
Authors: Chuklina Elena
Published: December 2020

The research subject is the scope of criminal law principles with double prevention which prevent not only the acts directly prohibited by law, but also other, usually much gravier crimes. The author considers the existing approaches to the definition of the term and the legal essence of principles with double provision. It is noted that the conventional definition is not universal and doesn’t reflect the essence and the mechanism of the preventive action of the principles. In its turn, the insufficient knowledge of the mechanism of preventive action of the principles with double prevention hampers their differentiation and systematization. Using the method of systems analysis and structural-functional analysis as a basis, as well as the dialectical, logical and formal legal methods as additional methods, the author arrives at the conclusion about the existence of two types of legal principles with double prevention which differ in the specificity of the mechanism of preventive action. The first type of principles with double prevention is aimed at preventing criminal deformation of a person at the early stages, while the second one - on the neutralization of criminogenic situations. The author formulates the definition of principles with double prevention which reflects the specificity of the mechanism of preventive action, and systematizes them in order to analyze the practical implementation of principles with double prevention.   
El pensamiento económico de la Escuela de Salamanca y la esclavitud negra
Authors: Iborra Mallent Juan Vicente , Valdés Guerrero Luis Raúl
Published: December 2020

Las reflexiones filosóficas, políticas, teológicas y económicas presentes en los autores de la Escuela de Salamanca nos ofrecen una visión privilegiada del mercado mundial que se fue conformando a partir de la expansión colonial. La trata de esclavos constituyó una parte fundamental de sus indagaciones, lo que exige un esfuerzo por desentrañar la emergencia de un pensamiento estrictamente económico respecto al comercio de esclavos negros africanos hacia América. Así, el problema moral presente en el acto de captura, que ha sido definido en la literatura especializada como «el problema de la esclavitud», fue opacado por una incipiente razón económica que solo puede ser entendida desde la aparición de la ciencia moderna de la economía y la proliferación de un poder soberano estatal que fue construyendo a su vez en los márgenes del sistema-mundo espacios periféricos de exclusión, apropiación y confinamiento.
Sistema de gestión de seguridad y salud en el trabajo: una revisión desde los planes de emergencia
Authors: Fagua-Quessed Gloria , De Hoz-Hernández Yina , Jaimes-Morales José
Published: December 2020

En el presente artículo se hizo una revisión sobre investigaciones recientes relacionadas con el sistema de gestión de seguridad y salud en el trabajo, principalmente en materia de planes de emergencia. Su objetivo es analizar cualitativamente la literatura científica disponible en las bases de datos Scielo, Science Direct, Redalyc y páginas Web oficiales, empleando como palabras de búsqueda: seguridad y salud en el trabajo, sistema de gestión de seguridad y salud en el trabajo, plan de emergencia. Se obtuvo información pertinente relacionada con el objetivo propuesto, la cual se presenta en 3 secciones: Seguridad y salud en el trabajo, sistema de gestión de seguridad y salud en el trabajo, planes de emergencia. Esta revisión proporciona herramientas teóricas para las instituciones en general comprometidas en la implementación de la gestión para la mejora continua de los procesos, en términos de competitividad y productividad.
Caracterização do usuário de substâncias psicoativas e a importância do serviço de álcool e outras drogas
Authors: Feitosa Sousa Paulo Henrique Santana , Almeida Thaynara Fontes , Azevedo Marcel Vinicius Cunha , Torres Ruth Cristini , Nunes Bárbara da Silva , E Santos Maria Aparecida Bispo Novais dos Santos , Feitosa Douglas Vinícius dos Santos , Júnior Gilverton Melo Santos
Published: December 2020

Objetivo: Pesquisar nas evidências científicas o perfil do usuário de substâncias psicoativas, bem como, esclarecer a importância do serviço de álcool e outras drogas. Métodos: Trata-se de uma revisão integrativa da literatura de caráter descritivo usando publicações das seguintes bases de dados: Literatura Latino-Americana do Caribe em Ciências da Saúde (LILACS), Scientific Electronic Library Online (SciELO) e Sistema Online de Busca e Análise de Literatura (MEDLINE). Resultados: A amostra foi constituída por 16 artigos, sendo 6 estudos de caráter transversal (38%), 4 sendo quantitativos (25%), sendo 3 artigos descritivos (19%), 2 fenomenológicos (12%) e 1 epidemiológico (6%). Conclusão: Constatou-se que a maior parte desse público eram homens solteiros com apenas um filho, com a faixa etária entre 20 e 60 anos, a maioria não havia concluído o ensino fundamental, apresentando entre 1 e 2 salários mínimos, predominando a cor parda e o álcool como a droga lícita mais utilizada. Nesse contexto, os Centros de Atenção Psicossocial tornam-se extremamente importantes pois visam garantir aos usuários uma nova forma de cuidados, possibilitando uma nova perspectiva da reinserção social, eliminando o foco da atenção centrada no controle e na repressão, por meio das atividades como participação em grupos ou oficinas e outras atividades educativas.
Educação permanente para profissionais da área da saúde como estratégia de combate ao enfretamento da pandemia de COVID-19 na região norte: relato de experiência
Authors: Zingra Karina Negrão , Da Silva Anitha de Cássia Ribeiro , Fernandes Ana Julia de Medeiros , Junior Arlindo Gonzaga Branco , Batista Maxwendell Gomes
Published: December 2020

Objetivo: Descrever o processo de capacitação à profissionais da saúde como forma de estratégia de combate ao enfrentamento da pandemia de covid-19 em municípios do Estado de Rondônia e do Amazonas. Relato de experiência: Foi realizado entre os meses de fevereiro e agosto de 2020 capacitações à profissionais de saúde por meio do processo de educação permanente. Se valendo de metodologias ativas como case based learning e ensino baseado em simulação. Foi proposto discussões de casos clínicos vivenciado no cotidiano por meio da formação de equipes multiprofissional e estimulação do debate e criação de estratégias para resolução afim de preparar melhor a atuação em equipe e desenvolver competências e habilidades em tais profissionais. Além disso, o uso de manequins realísticos possibilitou a aplicação prática como mais um aliado no processo de qualificação para futuros atendimentos e poder analisar a integração e estimular boas relações, preparando para um eficaz atendimento e resolutividade para os casos. Considerações finais: Tal processo, pode ser um facilitador para melhorar a estratégia de cuidado e integrar de forma harmônica as equipes que estariam na linha de frente ao combate do covid-19, lembrando-se que a integração e bons resultados no treinamento representariam melhor oferta e estratégia do cuidado.
Kinetika Ekstraksi Minyak Atsiri Lada Hitam (Piper nigrum) Secara Hidrodistilasi
Authors: Shintawati Shintawati , Analianasari Analianasari , Zukryandry Zukryandry
Published: December 2020

Lada hitam dikenal dengan nama King of Spices yang merupakan salah satu komoditi unggulan ekspor asal Provinsi Lampung. Lada hitam memiliki aroma dan rasa pedas yang khas. Kontribusi aroma berasal dari senyawa volatile yang terkandung pada minyak atsiri dalam lada hitam. Minyak atsiri lada diperoleh dari ekstraksi pelarut, hidrodistilasi, distilasi uap, distilasi fluida super kritik dan  hidrodistilasi menggunakan microwave. Nilai konsentrasi minyak atsiri selama ekstraksi serta laju ekstraksi dapat diprediksi dari model kinetika. Tujuan penelitian ini adalah mempelajari ekstraksi minyak atsiri lada hitam dan mengetahui model kinetika ekstraksi minyak atsiri lada hitam secara hidrodistilasi. Hidrodistilasi dilaksanakan selama 5 jam dengan pengambilan data setiap 15 menit. Hasil penelitian memperlihatkan kinetika ekstraksi lada hitam mengikuti model kinetika ekstraksi orde kedua.  Nilai parameter kinetika orde kedua dari ekstraksi minyak atsiri lada hitam yaitu kapasitas ekstraksi minyak atsiri lada,Cs, laju awal ekstraksi, h, dan konstanta laju ekstraksi, k masing-masing adalah 4,9 gL-1, 0,206 g L-1menit-1 dan 0,0086 g-1L menit-1 dan nilai determinasi sebesar 99,97%. Hasil eksperimen didapat perolehan ekstraksi sebesar 5,14%.
Analisis Pengaruh Pembiayaan Dan Simpanan Terhadap Pendapatan BNI Syariah Cabang Pekanbaru
Authors: Zulfa Marina , Kurnia Vievie Ova
Published: December 2020

Penelitian ini dilatar belakangi oleh perkembangan ekonomi saat ini yang semakin pesat, yaitu dengan munculnya lembaga keuangan syariah. Bank Negara Indonesia termasuk salah satu pelopor berdiri dan berkembangnya bank syariah di Indonesia. Produk-produk BNI Syariah yang bervariasi disediakan untuk masyarakat, misalnya simpanan dan pembiayaan. Tujuan dalam penelitian ini adalah untuk mengetahui bagaimana pengaruh pembiayaan dan simpanan secara parsial dan simultan terhadap pendapatan BNI Syariah. Jenis data yang digunakan yaitu data sekunder berupa laporan keuangan BNI Syariah. Analisis data yang digunakan yaitu analisis kuantitatif dimana proses penghitungannya menggunakan SPSS for windows versi 21. Dari hasil uji-F menunjukkan bahwa dari kedua variabel bebas (pembiayaan dan simpanan) secara bersama- sama mempunyai pengaruh yang signifikan terhadap pendapatan BNI Syariah Cabang Pekanbaru. Pembiayaan dan simpanan memiliki hubungan yang sangat kuat terhadap pendapatan BNI Syariah Cabang pekanbaru, ini diketahui dari nilai koefisien korelasi sebesar 98,5%. Kemudian terdapat kontribusi yang besar antara pembiayaan dan simpanan terhadap pendapatan BNI Syariah Cabang Pekanbaru,  hal ini diketahui dari besaran nilai koefisien determinasi yaitu sebesar 96,7%.
AUTIS CENTER DENGAN PENDEKATAN HEALING ENVIRONMENT
Authors: Simbolon Cory Glorya , Putro Jawas Dwijo , Alhamdani Muhammad Ridha
Published: December 2020

Based on data from the Pontianak City Population and Civil Registry Office, the highest population growth rate after West Pontianak occurred in North Pontianak. The population growth is accompanied by an increasing number of cases of people with ASD. The handling of autism which has so far been carried out with the establishment of therapeutic sites such as the Technical Service Unit (UPT) Autis Center in West Pontianak, and Special School (SLB) with the closest distance ± 14 km. As for other therapeutic sites in general is a function of the residence that still has distraction for people with ASD so that it is considered not sufficient enough. The supporting facilities available are deemed not fulfilling the needs of ASD in Pontianak, so there are still many cases of ASD sufferers who find it difficult to get expert treatment. For this reason, supporting facilities need to be held that can accommodate therapeutic activities in accordance with the character of persons with ASD.To design buildings that maximize the available environmental space and atmosphere program according to the type of needs and activities that are accommodated, the Healing Environment approach was chosen as the design solution for the Autis Center building. The Healing Environment approach is used to optimize the process of therapy, counseling, and education with an environment that can affect health through sensory and psychological patients with ASD.
Adaptive pixel mass recalibration for mass spectrometry imaging based on locally endogenous biological signals.
Authors: La Rocca Raphaël , Kune Christopher , Tiquet Mathieu , Stuart Lachlan , Eppe Gauthier , Alexandrov Theodore , De Pauw Edwin , Quinton Loïc
Published: December 2020

Mass spectrometry imaging (MSI) is a powerful and convenient method for revealing the spatial chemical composition of different biological samples. Molecular annotation of the detected signals is only possible if a high mass accuracy is maintained over the entire image and the m/z range. However, the heterogeneous molecular composition of biological samples could lead to small fluctuations in the detected m/z-values, called mass shift. The use of internal calibration is known to offer the best solution to avoid, or at least to reduce, mass shifts. Their “a priori” selection for a global MSI acquisition is prone to false positive detection and therefore to poor recalibration. To fill this gap, this work describes an algorithm that recalibrates each spectrum individually by estimating its mass shift with the help of a list of pixel specific internal calibrating ions, automatically generated in a data-adaptive manner (https://github.com/LaRoccaRaphael/MSI_recalibration). Through a practical example, we applied the methodology to a zebrafish whole body section acquired at high mass resolution to demonstrate the impact of mass shift on data analysis and the capability of our algorithm to recalibrate MSI data. In addition, we illustrate the broad applicability of the method by recalibrating 31 different public MSI datasets from METASPACE from various samples and types of MSI and show that our recalibration significantly increases the numbers of METASPACE annotations (gaining from 20 up to 400 additional annotations), particularly the high-confidence annotations with a low false discovery rate.
Xenon Gas Inhibits the Enzyme Furin In Vitro
Authors: Beihl David
Published: December 2020

Abstract:

Aims:

Certain cancers, pathogenic infections, and other diseases are facilitated by the host enzyme furin, a calcium-dependent serine protease that is the most prominent member of the family of proprotein convertases. Furin and the other proprotein convertases modify certain other proteins to change them from their inactive to active forms. Previous attempts to find an effective, non-toxic furin inhibitor to treat diseases facilitated by furin have had only limited success, due to toxicity or large molecular size that impedes absorption of the molecule. This has placed increased importance on the development of small-molecule furin inhibitors. The object of this study was to consider the effect of the noble gas xenon as a furin inhibitor.

Methods:

This study uses a fluorometric furin inhibition assay to compare the enzymatic activity of recombinant human furin after exposure to 99.999% xenon gas, compared to the enzymatic activity of untreated recombinant human furin.

Results:

Xenon exposure was found to decrease the in vitro enzymatic activity of recombinant human furin by 96-99%. Fluorescence measurements were taken for 24 hours and the enzyme inhibition persisted for the duration of the experiment. Further studies will be necessary to better characterize the exact duration of this inhibition.

Conclusions:

These findings appear to be the first to report xenon as a furin inhibitor. The observed inhibition continued throughout the duration of the experiment. The effectiveness of xenon as a furin inhibitor, its favorable side effect profile, and its long history of safe use as an anesthetic, when used under direct medical supervision, make it a promising treatment for diseases facilitated by furin or its substrates. Further studies in cell culture or clinical trials may expand its clinical role for such diseases.
Catalytic Synthesis of Cyclic Guanidines via Hydrogen Atom Transfer and Radical-Polar Crossover
Authors: Ohuchi Shunya , Koyama Hiroki , Shigehisa Hiroki
Published: December 2020

A catalytic synthesis of cyclic guanidines, which are found in many biologically active compounds and natu-ral products, was developed, wherein transition-metal hydrogen atom transfer and radical-polar crossover were employed. This mild and functional-group tolerant process enabled the cyclization of alkenyl guanidines bearing common protective groups, such as Cbz and Boc. This powerful method not only provided the common 5- and 6-membered rings but also an unusual 7-membered ring. The derivatization of the products afforded various heterocycles. We also investigated the se-lective cyclization of mono-protected or hetero-protected (TFA and Boc) alkenyl guanidines and their further derivatiza-tions.
A Benchmark of Popular Free Energy Approaches Revealing the Inhibitors Binding to SARS-CoV2 Mpro
Authors: Ngo Son Tung , Tam Nguyen Minh , Quan Pham Minh , Nguyen Trung Hai
Published: December 2020

COVID-19 pandemic has killed millions of people worldwide since its outbreak in Dec 2019. The pandemic is caused by the SARS-CoV-2 virus whose main protease (Mpro) is a promising drug target since it plays a key role in viral proliferation and replication. Currently, designing an effective therapy is an urgent task, which requires accurately estimating ligand-binding free energy to the SARS-CoV-2 Mpro. However, it should be noted that the accuracy of a free energy method probably depends on the protein target. A highly accurate approach for some targets may fail to produce a reasonable correlation with experiment when a novel enzyme is considered as a drug target. Therefore, in this context, the ligand-binding affinity to SARS-CoV-2 Mpro was calculated via various approaches. The Autodock Vina (Vina) and Autodock4 (AD4) packages were manipulated to preliminary investigate the ligand-binding affinity and pose to the SARS-CoV-2 Mpro. The binding free energy was then refined using the fast pulling of ligand (FPL), linear interaction energy (LIE), molecular mechanics-Poission Boltzmann surface area (MM-PBSA), and free energy perturbation (FEP) methods. The benchmark results indicated that for docking calculations, Vina is more accurate than AD4 and for free energy methods, FEP is the most accurate followed by LIE, FPL and MM-PBSA (FEP > LIE > FPL > MM-PBSA). Moreover, the binding mechanism was also revealed by atomistic simulations. The vdW interaction is the dominant factor. The residues Thr25, Thr26, His41, Ser46, Asn142, Gly143, Cys145, Glu166, and Gln189 are essential elements affecting on the binding process. Furthermore, the Ser46 and related residues probably are important elements affecting the enlarge/dwindle of the SARS-CoV-2 Mpro binding cleft. The benchmark probably guide for further investigations using computational approaches.
COVID-19: A systematic approach to solve the dilemma
Authors: Swapnil Mohod  , Siddhi Shirish Nemade  , Yash Santosh Goenka  , Shreya Neeraj Jain  , Shraddha Aditya Patel  , Kumar Gaurav Chhabra
Published: December 2020

Corona Virus Disease (COVID-19)- the 2019-2020 pandemic, has augmented all over the globe. This virus is accountable for millions of infections and hundreds of deaths in people. It is dependent on humans for its transmission as the virus cannot spread on its own and survives only on contaminated surfaces for a definite period. The mortality rate scales low, but it harms the social, economic and psychological well being of people. There is mass hysteria about this disease in the society, leading to the outbreak of misinformation, misconception and rumours. Such false beliefs regarding this virus can worsen the effects of this disease. People believing these conspiracy theories have trust issues with the healthcare professionals, thus, making them disoblige the medical advice. In this moment of crisis, it is essential to dissect these conspiracy theories and have a fact check regarding all the aspects surrounding the disease. Otherwise, these myths will be an obstacle in the fight against COVID-19. In this paper, we have tried to resolve these myths through fact findings.