bluuebunny/crossref_metadata_2025 huggingface dataset:
3D and 2D-QSAR Studies on Natural Flavonoids for Nitric Oxide Production Inhibitory Activity
Authors: Wang Chunqiang , Fan Yuzhu , Pei Minfan , Yan Chaoqun , Liang Taigang
Published: January 2024

Background:

Nitric oxide (NO), an important second messenger molecule, regulates numerous
physiological responses, while excessive NO generates negative effects on the circulatory,
nervous and immune systems. Recently, some natural flavonoids were reported to possess the capability
of inhibiting LPS-induced NO production. To fully understand the nature of their own NO
inhibitory activity, it is necessary to address the structural requirements of flavonoids as NO inhibitors.

Objective:

The objective of this work was to develop efficient QSAR models for predicting the NOinhibitory
activity of new flavonoids and improving insights into the critical properties of the chemical
structures that were required for the ideal NO production inhibitory activities.

Methods:

To provide insights into the structural basis of flavonoids as NO inhibitors, 3D quantitative
structure-activity relationship (3D-QSAR) and 2D-QSAR models were developed on a dataset of 55
flavonoids using comparative molecular field analysis (CoMFA), comparative molecular similarity
indices analysis (CoMSIA) and hologram quantitative structure-activity relationship (HQSAR) approaches.

Results:

The statistically significant models for CoMFA, CoMSIA and HQSAR resulted in crossvalidated
coefficient (q2) values of 0.523, 0.572 and 0.639, non-cross-validated coefficient (r2) values
of 0.793, 0.828 and 0.852, respectively. The robustness of these models was further affirmed
using a test set of 18 compounds, which resulted in predictive correlation coefficients (r2
pred) of 0.968,
0.954 and 0.906. Furthermore, the models-derived contour maps were appraised for activity trends
for the molecules analyzed.

Conclusion:

The 3D and 2D-QSAR models constructed in this paper were efficient in estimating the
NO inhibitory activities of flavonoids and facilitating the design of flavonoid-derived NO production
inhibitors.
Genetic Determinants of Response to Statins in Cardiovascular Diseases
Authors: Ghorbannezhad Ghazaleh , Mehrabadi Shima , Golampour-Shamkani Negar , Barjasteh Amirhossein , Etesamizadeh Poorya , Tayyebi Mohammad , Khazaei Majid , Hassanian Seyed Mahdi , Ferns Gordon A , Avan Amir
Published: January 2024

Despite extensive efforts to identify patients with cardiovascular disease (CVD) who
could most benefit from the treatment approach, patients vary in their benefit from therapy and
propensity for adverse drug events. Genetic variability in individual responses to drugs (pharmacogenetics) is considered an essential determinant in responding to a drug. Thus, understanding these pharmacogenomic relationships has led to a substantial focus on mechanisms of disease and drug response. In turn, understanding the genomic and molecular bases of variables that
might be involved in drug response is the main step in personalized medicine. There is a growing
body of data evaluating drug-gene interactions in recent years, some of which have led to FDA
recommendations and detection of markers to predict drug responses (e.g., genetic variant in
VKORC1 and CYP2C9 genes for prediction of drug response in warfarin treatment). Also,
statins are widely prescribed drugs for the prevention of CVD. Atorvastatin, fluvastatin, rosuvastatin, simvastatin, and lovastatin are the most common statins used to manage dyslipidemia. This
review provides an overview of the current knowledge on the pharmacogenetics of statins, which
are being used to treat cardiovascular diseases.
Imaging Features and Misdiagnosis of Giant Cerebral Cavernous
Malformations
Authors: Xiao Mengqiang , Zhang Meng , Lei Min , Lin Fenghuan , Chen Yanxia , Liu Jingfeng , Chen Jun , Luo Nianyuan
Published: January 2024

Background:

While cerebral cavernous malformations (CCMs) have been extensively described, few reports have described the imaging appearance of giant
CCMs (GCCMs).

Objective:

To describe the imaging characteristics of GCCMs and study the reasons for preoperative misdiagnosis.

Methods:

We retrospectively analyzed the data of 12 patients (5 men, 7 women; mean age, 35.23 ± 12.64 years) with histopathologically confirmed GCCMs.
Two radiologists analyzed the CT (n = 12) and MRI (n = 10) features: location, number, size, shape, boundary, signal intensity, and enhancement.

Results:

The sellar region, cerebral hemisphere, skull bone, and ventricle were involved in 5, 4, 2, and 1 patients, respectively. Three tumors were
irregularly shaped, while nine were oval. Eleven lesions showed slightly high- and/or high-density on CT; 1 lesion appeared as a low-density cyst.
Calcifications were found in 11 lesions. Four tumors showed uniform hypointensity on T1-weighted imaging (T1WI) and hyperintense signals on
T2-weighted imaging (T2WI). Six tumors showed mixed low-, equal-, and high-intensity signals on T1WI and T2WI. Noticeable contrast
enhancement and gradual strengthening were noted on T1WI. Ten lesions showed hemorrhage and hemosiderin deposition. The GCCMs were
wrongly diagnosed as cartilage-derived tumors/ meningioma (3 patients); tumor and hematoma (2 patients each); and pituitary tumor/ meningioma,
chondroma, chordoma, ependymoma, and macroadenoma (1 patient each).

Conclusions:

GCCMs present as an oval mass with slightly high- and/or high-density calcifications on CT and show hemorrhage and hemosiderin accumulation
on MRI. Therefore, slightly high- and/or high-density calcification and hemosiderin accumulation are critical clinical characteristics of GCCMs
The Evolution of Medical Imaging in the Therapeutics of Patients with Skin
Cancer
Authors: Brar Khushmeen Kaur , Shiney O Jeba , Goyal Bhawna , Dogra Ayush
Published: January 2024

Introduction:

Medical imaging mechanization has reformed medical management, empowering doctors to recognize cancer prematurely and promote patient
outcomes. Imaging tests are of significant influence in the detection and supervision of cancer patients. Cancer recognition generally necessitates
imaging studies that, in most instances, utilize a trivial amount of radiation. Methodologies such as X-rays, computed tomography (CT), magnetic
resonance imaging (MRI), and positron emission tomography (PET) are predominant in clinical managerial, incorporating remedy and research

Background:

Over recent years, diagnostic imaging has progressed from a state of commencement to an advanced level. Numerous modern imaging procedures
have evolved. Although contemporary medical imaging comprises image exhibition together with image refining, computer-aided diagnosis
(CAD), image inscribing and conserving, and image transference, the majority of which are embraced in picture documentation and
communication processes.

Aim:

This review targets to encapsulate toxicology information on skin cancer unpredictability essential to interpretation measures, report important
factor that helps in defining skin cancer condition, and possible medical care alternatives or medical attention endorsed referring to diverse aspects
involving the size and site of malignancy, the complications, patient’s priority and well being. We concisely review various therapy alternatives,
methods of radiation autoimmunity, prime observational study designs of medical and distinct radiation resources and cancer risks, and current
analysis methodologies and research precision.

Conclusion:

The detail of this paper covers a brief review of research and evolution in medical imaging discipline and mechanism. This review considers the
physiology of melanocytes and the pathogenesis of skin cancer using medical imaging. Also, a description of risk factors, prevention methods,
screening, various diagnosis methods and different stages of skin cancer, sub-types and different types of treatment methods is provided in this
paper for research and development.
Exploration of Pharmacological Mechanisms of Dapagliflozin against Type
2 Diabetes Mellitus through PI3K-Akt Signaling Pathway based on
Network Pharmacology Analysis and Deep Learning Technology
Authors: Wu Jie , Chen Yufan , Shi Shuai , Liu Junru , Zhang Fen , Li Xingxing , Liu Xizhi , Hu Guoliang , Dong Yang
Published: January 2024

Background::

Dapagliflozin is commonly used to treat type 2 diabetes mellitus
(T2DM). However, research into the specific anti-T2DM mechanisms of dapagliflozin remains
scarce.

Objective::

This study aimed to explore the underlying mechanisms of dapagliflozin against
T2DM.

Methods::

Dapagliflozin-associated targets were acquired from CTD, SwissTargetPrediction,
and SuperPred. T2DM-associated targets were obtained from GeneCards and DigSee. VennDiagram
was used to obtain the overlapping targets of dapagliflozin and T2DM. GO and KEGG
analyses were performed using clusterProfiler. A PPI network was built by STRING database
and Cytoscape, and the top 30 targets were screened using the degree, maximal clique centrality
(MCC), and edge percolated component (EPC) algorithms of CytoHubba. The top 30 targets
screened by the three algorithms were intersected with the core pathway-related targets to obtain
the key targets. DeepPurpose was used to evaluate the binding affinity of dapagliflozin with the
key targets.

Results::

In total, 155 overlapping targets of dapagliflozin and T2DM were obtained. GO and
KEGG analyses revealed that the targets were primarily enriched in response to peptide, membrane
microdomain, protein serine/threonine/tyrosine kinase activity, PI3K-Akt signaling pathway,
MAPK signaling pathway, and AGE-RAGE signaling pathway in diabetic complications.
AKT1, PIK3CA, NOS3, EGFR, MAPK1, MAPK3, HSP90AA1, MTOR, RELA, NFKB1,
IKBKB, ITGB1, and TP53 were the key targets, mainly related to oxidative stress, endothelial
function, and autophagy. Through the DeepPurpose algorithm, AKT1, HSP90AA1, RELA,
ITGB1, and TP53 were identified as the top 5 anti-targets of dapagliflozin.

Conclusion::

Dapagliflozin might treat T2DM mainly by targeting AKT1, HSP90AA1, RELA,
ITGB1, and TP53 through PI3K-Akt signaling.
HPLC Analysis of Vitamins C, E, Beta-carotene, and Some Flavonoids in
Armenian Red Wines
Authors: Grigoryan Ani A. , Hayrapetyan Ani A. , Azaryan Zhermen A. , Harutyunyan Siranush V. , Yengoyan Aleksandr P.
Published: January 2024

Background:

Oxidative damage to biological molecules is mainly caused by free radicals
produced in the body. Natural antioxidants can prevent the resulting oxidative stress. For this purpose,
particularly grapes and grape products, which contain vitamins and polyphenolic substances
with high antioxidant activity, are used.

Methods:

In the present study, the content of vitamins C and E, beta-carotene, and some flavonoids
(+)-catechin, quercetin, and trans-resveratrol) in the composition of 19 brands of red wines that are
produced in Armenia, was determined by HPLC. Vitamins C, E, beta-carotene, as well as flavonoids
manufactured by Sigma-Aldrich were used as standards.

Results:

The amounts of vitamin E and beta-carotene were below the sensitivity threshold of the
method, and the content of vitamins C and flavonoids varied over a wide range (vitamins C 2.15-
56.1, (+)-catechin 0-620.3; quercetin 0-10.55; trans-resveratrol 0-5.89 mg/L).

Conclusion:

The chromatographic analysis of vitamins and flavonoids allowed us to investigate not
only the content of useful substances that make up red wines but also to identify counterfeit products.
In this study, wines presented directly to retailers were analyzed since the task was both to determine
vitamins and flavonoids and to identify counterfeits. The results of our study showed that among all
the selected wine brands, there were no samples that, in terms of their properties, would not meet the
required parameters.
Differentiation of Acute Leukemia Cells Including Cells with MLL-AF4 Rearrangements Induced by Jiyuan Oridonin A
Authors: Li Xueming , Zhang Fenglian , Ke Yu , Liu Hongmin , Hu Zhenbo , Wei Liuya
Published: January 2024

Background:

Chromosomal rearrangements involving the Mixed lineage leukemia
(MLL) gene are observed in acute leukemia (AL) patients, which have poor prognosis, especially
in infants. Hence, there is still a challenge to develop other effective agents to treat AL with MLL
rearrangements (MLLr). MLL has been shown to rearrange with partner genes, of which the most
frequently observed are AF4 and AF9. Moreover, AL is characterized by a differentiation blockage
resulting in the accumulation of immature cells. An ent-kaurene diterpenoid compound, Jiyuan
Oridonin A (JOA), has been shown to reduce the viability of AML cells by differentiation.

Methods:

We aimed to evaluate the effect of JOA on the growth and differentiation of AL cells
(SEM, JURKAT and MV4-11) including cells with MLLr-AF4 by cell proliferation assay, colony
formation assay, cell cycle analysis, cell apoptosis analysis, measurement of cell surface
antigens and cell morphology, mRNA-sequencing analysis, quantitative Real-time PCR and
Western blotting analysis.

Results:

Our findings demonstrated that the proliferation of AL cells including cells with
MLLr-AF4 was significantly suppressed by JOA, which induced cell differentiation followed
by G0/G1 cell cycle withdrawal. Moreover, JOA-mediated cell differentiation was likely due to
activation of G-CSFR in MV4-11 cells.

Conclusion:

Our results suggest that JOA may be considered a promising anti-leukemia compound
to develop to surmount the differentiation block in AL patients
Vesicular Nanocarriers: A Potential Platform for Topical/Transdermal
Delivery of Antibiotics
Authors: Chadha Mohit , Malik Deepinder Singh
Published: January 2024

Background:

Bacterial infections are becoming difficult to treat nowadays due to the development of resistance towards conventional treatments. Conventional topical formulations loaded
with antibiotics display various disadvantages, like high dosing frequency, high toxicity, and poor
patient compliance. The former limitations may sometimes lead to severe complications and hospitalization of patients. However, these can be overcome by employing vesicular nanocarriers for the delivery of antibiotics following the topical/transdermal route.

Objective:

The objective of this review paper was to summarize the role of vesicular nanocarriers, like
liposomes, elastic liposomes, niosomes, ethosomes, solid lipid nanoparticles, nanostructured lipid carriers, and nanoemulsions for topical/transdermal delivery of antibiotics, and patents associated with them.

Methods:

Literature for the present review was collected using various search engines, like PubMed,
Google Scholar, and Google Patents.

Results:

Various literature investigations have revealed the in vitro and preclinical efficacy of vesicular nanocarrier systems in the delivery of antibiotics following the topical/transdermal route.

Conclusion:

Vesicular nanocarrier systems, via targeted delivery, may subside various side effects of
antibiotics associated with conventional delivery, like high dosing frequency and poor patient compliance. However, their existence in the pharmaceutical market will be governed by effective clinical
assessment and scale-up methodologies.
Literature Review on IoT-based Smart Retailing Management Systems in the Context of Smart Cart
Authors: Gupta Paras , Verma Gourav , Chauhan Aakash , Singh Neha , Pandey Meghna , Kukreti Kamlesh , Joshi Alankrita
Published: January 2024

IoT technology has revolutionized retail, giving rise to Smart Retailing Management
Systems (SRMS). This review explores IoT-based SRMS focusing on smart carts, investigating
enhancements in shopping experiences like RFID tags, dynamic inventory management, and personalization.
By comparing research and products, it evaluates SRMS in technology, cost, reliability,
security, power use, and components. The goal is to unveil SRMS’s strengths and weaknesses,
aiding retail progress.

Objective:

This study aimed to review IoT-based Smart Retailing Management Systems (SRMS)
centered on smart carts, explore IoT's role in enhancing shopping, spotlighting RFID tags, dynamic
inventory, and personalization, and evaluate SRMS via tech, cost, reliability, security, power,
and components, unveiling diverse strengths and weaknesses.

Method:

A literature search in previous works and patents was conducted. The findings to pinpoint
trends, tech shifts, and research gaps were analyzed. The real-world studies were synthesized
to discuss IoT-based SRMS progress and an inclusive view of various approaches and outcomes
was offered.

Conclusion:

IoT-based SRMS, especially in smart retail carts, elevate shopping via RFID tags,
dynamic inventory, and personalization. The comparative analysis exposes SRMS potential and
constraints, offering insights for informed retail decisions and advancement.
The Radioprotective Effect of LBP on Neurogenesis and Cognition after Acute Radiation Exposure
Authors: Yin Gang , Wang Qinqi , Lv Tongtong , Liu Yifan , Peng Xiaochun , Zeng Xianqin , Huang Jiangrong
Published: January 2024

Background:

Radiation exposure has been linked to the development of brain damage and cognitive impairment, but the protective effect and mechanism of Lycium barbarum pills (LBP) on radiation-induced neurological damage remains to be clarified.

Methods:

Behavioral tests and immunohistochemical studies were conducted to evaluate the protective effects of LBP extract (10 g/kg orally daily for 4 weeks) against radiation-induced damage on neurogenesis and cognitive function in Balb/c mice exposed to 5.5 Gy X-ray acute radiation.

objective:

To study the protective effect and mechanism of Lycium barbarum pills(LBP) on radiation induced neurological damage.

Results:

The results showed that the LBP extract significantly improved body weight loss, locomotor activity and spatial learning and memory. Immunohistochemical tests revealed that the LBP extract prevented the loss of proliferating cells, newly generated neurons and interneurons, especially in the subgranular area of the dentate gyrus.

Conclusion:

The findings suggest that LBP is a potential neuroprotective drug for mitigating radiation-induced neuropsychological disorders.
Técnicas Biblioteconómicas aplicação dessas técnicas no Centro de Multimeios Poeta Alberto de Moura, da cidade de Ipaumirim-CE
Authors: Pontes Vanildo Pereira
Published: January 2024

The research carried out in this article focuses on an ever-recurring theme in discussions about library techniques in the school library, specifically in the state of Ceará, through the Ceará Department of Education (SEDUC), according to its document, hasbeen adopting the replacement of this environment for the Multimedia Centre, whose discussions are involved in the form of organization and access to the information contained in its collection for the needs of its users. This project aims to investigate the application of library techniques in the Alberto de Moura Poet Multimedia Center for the dissemination and accessibility of information in developing the school community. The opportunity to work at the Poeta Alberto de Moura Multimedia Center has helped to broaden our knowledge and practices in the field of librarianship. The implementation of this project benefited both the educational institution that hosted the research and the community involved, as it concerned the participation of the entire school community and resulted in positive outcomes that will contribute to the development of both the schooland the community in educational, social and, cultural terms.
A contribuição da nova biblioteconomia de Lankes para decolonializar o conhecimento
Authors: Ferreira Emanuelle Geórgia Amaral , Araújo Carlos Alberto Ávila
Published: January 2024

Thiswork presents the contribution of the perspective conceived by R. David Lankes with the publication of the Atlas of the New Librarianship, in 2011-the NewLibrarianship-, to decolonialize knowledge. The construction of this work had as a principle for analysis the mission of the librarian,which is the basis of the New Librarianship,’s perpective,the presentation and conceptualization of this concept andcoloniality and decolonialityconcepts. Lankes' New Librarianship brings reflection on the importance of empowering communities through the creation of knowledge and positions the librarian as an active subject in the participation of this collective construction. Thus, the perspective contributes to the decoloniality of knowledge by positioning the community as the true informational input beyond the boundaries of the book as an informational record of knowledge. Knowledge is found in every member of the community and it is the librarian's role to give voice to that knowledge.
A chegada da information literacy no Brasil apropriação conceitual e implicações para as traduções
Authors: Alves Mariana de Souza , Macedo Maria do Socorro Alencar Nunes , Galindo Marcos
Published: January 2024

It presents how discussions about Information Literacy, widely discussed in the American context, echoed on Brazilian soil, in order to provide a historical-conceptual overview to support studies in the area. It characterizes the theme based on its historical, conceptual-empirical and critical constitution, and the terminological and translation implications in Brazil. It uses seminal works by the first Brazilian researchers who have discussed the topic of Information Literacy (and its translations) since the beginning of the 2000s; US institutional documents and national scientific productions on the subject. It verifies that the educational function of Information Literacy was one of the attractions for the arrival of the concept in Brazil and for its appropriation by studies on Library and Education, therefore, the conceptual elements about learning and the school library are present in the different translations. It concludes that Information Literacy arises under specific conditions to meet the needs of its country of origin. Among the challenges faced in this appropriation movement, in addition to the social and economic difficulties in Brazil, which are little similar to those of the United States, there are challenges at the linguistic and epistemological level, especially in its translation and conceptualization.
Políticas públicas arquivísticas nas pesquisas dos programas de pós-graduação STRICTO SENSU EM Ciência da Informação do Brasil
Authors: Gonçalves Eliane Silveira , Marques Angelica Alves da Cunha
Published: January 2024

This article aims to map the scientific production of stricto sensupostgraduate programs in Information Science in Brazil, in order to study archival public policies, the subject of an ongoing thesis. This is a quali-quantitative, exploratory and descriptive research carried out in two stages. In the first, 74 works were identified, throughsearches in the Catalog of Theses and Dissertations of the Coordination for the Improvement of Higher Education Personnel(CAPES). In the second, using bibliographical research techniques, reflective readings were carried out to prepare a systematic literature review with the identified data. Of the 74 works, 46 were used in the research because they were produced in Information Science programs. From its analysis, it is concluded that there is agreement on the use of the terms archival policies and archival public policies as synonyms, as well as on the lack of archival public policies in Brazil, despite the legislation in the area. The works of José Maria Jardim are the most used references in discussions about archival policies and archival public policies, in the analyzed material.
Literatura - Competência (inter)cultural – (P)LE revendo argumentos, encurtando distâncias entre os saberes e as práticas
Authors: Ramon Micaela
Published: January 2024

Although resistance persists towards the inclusion of literary textual typologies in the study plans of foreign language courses, there are currently numerous theoretical works and reports of pedagogical-didactic experiences that prove the relevance of such an option. The progressive affirmation of the intercultural approach opened up the possibility of viewing the literary text as a privileged instrument of access to a given language-culture, allowing not only direct contact with linguistic and cultural patterns of the target language, but also its comparison with the similar standards of the language(s)-culture(s) of origin of the learners. When it comes to a pluricentric language like Portuguese, studied by students from geographically and culturally verydistant and heterogeneous contexts, the use of these texts can prove to be a powerful ally both from the point of view of acquiring linguistic and communicative skills, as a means of accessing the cultural imaginary of Portuguese-speaking communities. This article aims to (1) theoretically frame the relationships between (P)LE, literary text and (inter)cultural competence; and (2) demonstrate the potential of this type of texts for the development of mediation skills between cultures, in the context of current globalized societies.
Studi Manajemen Konstruksi Proyek Pembangunan Pelimpah Pada Bendungan Bendo Metode Fasttrack dan Crashing
Authors: Muhammad Dien Azmi , Pitojo Tri Juwono  , Evi Nur Cahya
Published: January 2024

Pelaksanaan proyek kontruksi membutuhkan perancanaan yang matang agar dapat terselesaikan secara efektif dan efisien. Proyek Pembangunan Pelimpah Pada Bendungan Bendo Kabupaten Ponorogo dimana dalam pelaksanaanya memiliki banyak sub item sehingga diperlukan manajemen kontruksi yang tepat agar pembangunannya dapat mencapai target secara efektif dan efisien. Waktu, biaya dan mutu merupakan tiga hal penting yang harus diperhatikan dalam suatu proyek konstruksi. Pada studi ini untuk mempercepat waktu penyelesaian proyek digunakan metode fasttrack dan crashing. Hal tersebut dilakukan dengan cara merekayasa lintasan kritis dan melakukan percepatan penjadwalan sehingga berdampak pada efektivitas durasi proyek. Dari hasil analisa dengan metode fasttrack, dilakukan optimasi dengan menghasilkan durasi proyek yang lebih efektif yaitu 5,9% dari durasi awal kontrak dan menghasilkan biaya proyek yang lebih efisien yaitu 0,3% dari biaya proyek. Dengan menggunakan metode crashing, dilakukan optimasi dengan menambah jam kerja selama 2 jam pada sumberdaya manusianya. Dari optimasi tersebut dengan menghasilkan durasi proyek yang lebih efektif yaitu 2,9%  dari durasi awal kontrak dan menghasilkan biaya proyek yang lebih efisien yaitu 0,51% dari biaya proyek.  Dari hasil optimasi didapatkan hasil bahwa metode fasttrack lebih unggul dalam segi optimasi jadwal proyek. Sedangkan, metode crashing lebih unggul dalam proyeksi anggaran (biaya akhir proyek).
El imaginario del miedo en los subcentros turísticos en Culiacán
Authors: Rodriguez Gonzalez Sylvia Cristina
Published: January 2024

El territorio turístico en Culiacán se ha destacado por centros turísticos reconocidos de manera regional y por estructuras urbanas que se enmarcan en rutas turísticas o recorridos tradicionales, hasta recorridos hacia el interior de la ciudad, con dos énfasis: el turismo histórico y el turismo obscuro. Sin embargo, el nuevo turismo detonado después de la pandemia ha sido el turismo rural: salir del núcleo urbano para conocer otros territorios a los que pueden desplazarse, conectarse con sitios cercanos destinados a los espacios de recreación y también de naturaleza, hasta la concentración de turistas locales o regionales, en proyectos muy puntuales que durante la implementación de grandes proyectos urbanos se consolidaron hacia el interior de la ciudad y que ahora forman parte de nuevos subcentros turísticos de gran atractivo y concentración de grupos separados del reconocimiento y atractivo. No obstante, el riesgo es latente y el miedo es generado en los diversos espacios de la ciudad y las comunidades aledañas en el municipio de Culiacán.
Examining the relationship between the Role of Personality Traits and Work-Life Balance
Authors: Neeti Sharma
Published: January 2024

The aim of the paper is to analyse the significance of work life balance factors of IT Sector of NCR on the basis of their personality traits.This study is based on primary method of data collection.. Data was collected through questionnaire method of 350 employees working inIT sector. Questionnaires was based on demographic characteristic, work- life factors and personality traits. First the Big five Personlitytraits were analysed, then ANOVA was used to measure significance between BFP and work-life factors. Results suggest thatagreeableness were the most balanced one trait while other traits faced challenges and conflict in managing work and life. Secondly in theanalysis it was determined that there was significant relation between personality and work and life balance factors. This meanspersonality is one of the important factor that directly or indirectly affects work and life. This findings will help organization in managingemployee work-life interface for maximizing individual and organizational outcomes by knowing their personality trait. The study islimited to the only employees of NCR so results cannot be generalized.Keywords: Big five Personality (BFP), Work-life, work-family, personality, organization culture, work family conflict.
Causales de aplicación del principio de oportunidad en el Derecho Penal Ecuatoriano
Authors: Hoyos Zavala Estrella , Alfonso Caveda Duniesky
Published: January 2024

El presente trabajo de investigación estuvo dirigido a analizar los causales de la aplicación del principio de oportunidad en el derecho penal ecuatoriano, con la finalidad de estudiar la importancia de la aplicación de este principio y destacando los requisitos que la legislación del Ecuador establece para que proceda la abstención de iniciar la investigación penal o el desistimiento de la ya iniciada. Cada una de los preceptos abordados permitieron establecer las diversas reglas necesarias para prescindir de la acusación penal. La metodología empleada fue documental, descriptiva y se empleó el método exegético y sistemático, con la finalidad de conocer, interpretar y reflexionar sobre el contenido de la norma a nivel nacional. Así mismo, la revisión de diversas fuentes bibliográficas permitió desarrollar un análisis exhaustivo de la temática de estudio, considerando las acciones impartidas en el tratamiento penal y aplicación de esta figura. Por lo tanto, en función del desarrollo documental y legislativo, se pudo concluir que la inclusión del principio de oportunidad en la legislación ecuatoriana se ha dado para obtener un método imperioso de descongestión dentro del ejercicio de la acción penal, aplicando un sistema simplificado una vez que se haya esgrimido un criterio ético, intelectual y racional de quien ejerza el ejercicio de la acción penal pública. En este sentido, existen una serie de requisitos o causales que son indispensables para que opere este principio, referidos a los casos cuando no comprometa gravemente el interés público, cuando no implique vulneración a los intereses del estado, cuando exista una pena privativa de libertad máxima de hasta cinco años, cuando el infractor sufriere un daño físico grave que le imposibilite llevar una vida normal y en los casos de delitos culposos.
El Aprendizaje Basado en Problemas como instrumento catalizador de competencias del discente universitario
Authors: Mohamed-Amar Rachida , Mohamed-Amar Horía , Mohamed Amar Ahmida
Published: January 2024

En un entorno educativo en incesante evolución, el aprendizaje basado en problemas (ABP) se erige como una estrategia educativa innovadora que promueve el desarrollo académico del discente. El ABP se caracteriza por su enfoque centrado en el estudiante, donde los participantes asumen un papel activo en la construcción de su propio conocimiento. El objetivo del presente estudio gira en torno a la evaluación del impacto del ABP en el desarrollo de competencias clave, como el pensamiento crítico, la toma de decisiones éticas, el aprendizaje activo, las habilidades de trabajo en equipo y colaboración, las habilidades de investigación, la autorreflexión y las competencias digitales, en un contexto universitario. La investigación fue desarrollada bajo un diseño no experimental, con enfoque cuantitativo, descriptivo y de corte transversal. Los resultados obtenidos proporcionan evidencia empírica sólida sobre la capacidad del aprendizaje basado en problemas para fomentar el desarrollo de competencias en estudiantes universitarios.
Office Workers’ Views About the Uses, Concerns, and Acceptance of Hand Hygiene Data Collected From Smart Sanitizers: Exploratory Qualitative Interview Study
Authors: Rutter Sophie , Sanger Sally , Madden Andrew D , Ehdeed Sukaina , Stones Catherine
Published: January 2024

Background

COVID-19 and the prospect of future pandemics have emphasized the need to reduce disease transmission in workplaces. Despite the well-established link between good hand hygiene (HH) and employee health, HH in nonclinical workplaces has received little attention. Smart sanitizers have been deployed in clinical settings to motivate and enforce HH. This study is part of a large project that explores the potential of smart sanitizers in office settings.

Objective

Our previous study found that for office workers to accept the deployment of smart sanitizers, they would need to find the data generated as useful and actionable. The objectives of this study were to identify (1) the potential uses and actions that could be taken from HH data collected by smart sanitizers (2) the concerns of office workers for the identified uses and actions and (3) the circumstances in which office workers accept HH monitoring.

Methods

An interview study was conducted with 18 office workers from various professions. Interview questions were developed using a framework from personal informatics. Transcripts were analyzed thematically.

Results

A wide range of uses of smart sanitizer data was identified including managing hygiene resources and workflows, finding operating sanitizers, communicating the (high) standard of organizational hygiene, promoting and enforcing organizational hygiene policies, improving workers’ own hygiene practices, executing more effective interventions, and identifying the causes of outbreaks. However, hygiene is mostly considered as a private matter, and it is also possible that no action would be taken. Office workers were also concerned about bullying, coercion, and use of hygiene data for unintended purposes. They were also worried that the data could be inaccurate or incomplete, leading to misrepresentation of hygiene practices. Office workers suggested that they would be more likely to accept monitoring in situations where hygiene is considered important, when there are clear benefits to data collection, if their privacy is respected, if they have some control over how their data are collected, and if the ways in which the data will be used are clearly communicated.

Conclusions

Smart sanitizers could have a valuable role in improving hygiene practices in offices and reducing disease transmission. Many actionable uses for data collected from smart systems were identified. However, office workers consider HH as a personal matter, and acceptance of smart systems is likely to be dynamic and will depend on the broad situation. Except when there are disease outbreaks, smart systems may need to be restricted to uses that do not require the sharing of personal data. Should organizations wish to implement smart sanitizers in offices, it would be advisable to consult widely with staff and develop systems that are customizable and personalizable.
The Association Between Linguistic Characteristics of Physicians’ Communication and Their Economic Returns: Mixed Method Study (Preprint)
Authors: Geng Shuang , He Yuqin , Duan Liezhen , Yang Chen , Wu Xusheng , Liang Gemin , Niu Ben
Published: January 2024

BACKGROUND

Web-based health care has the potential to improve health care access and convenience for patients with limited mobility, but its success depends on active physician participation. The economic returns of internet-based health care initiatives are an important factor that can motivate physicians to continue their participation. Although several studies have examined the communication patterns and influences of web-based health consultations, the correlation between physicians’ communication characteristics and their economic returns remains unexplored.

OBJECTIVE

This study aims to investigate how the linguistic features of 2 modes of physician-patient communication, instrumental and affective, determine the physician’s economic returns, measured by the honorarium their patients agree to pay per consultation. We also examined the moderating effects of communication media (web-based text messages and voice messages) and the compounding effects of different communication features on economic returns.

METHODS

We collected 40,563 web-based consultations from 528 physicians across 4 disease specialties on a large, web-based health care platform in China. Communication features were extracted using linguistic inquiry and word count, and we used multivariable linear regression and K-means clustering to analyze the data.

RESULTS

We found that the use of cognitive processing language (ie, words related to insight, causation, tentativeness, and certainty) in instrumental communication and positive emotion–related words in affective communication were positively associated with the economic returns of physicians. However, the extensive use of discrepancy-related words could generate adverse effects. We also found that the use of voice messages for service delivery magnified the effects of cognitive processing language but did not moderate the effects of affective processing language. The highest economic returns were associated with consultations in which the physicians used few expressions related to negative emotion; used more terms associated with positive emotions; and later, used instrumental communication language.

CONCLUSIONS

Our study provides empirical evidence about the relationship between physicians’ communication characteristics and their economic returns. It contributes to a better understanding of patient-physician interactions from a professional-client perspective and has practical implications for physicians and web-based health care platform executives.
Gallbladder Cancer Incidence and Mortality Rate Trends in China: A National Population-based Cancer Registry (Preprint)
Authors: Ma Wenjun
Published: January 2024

BACKGROUND

Gallbladder cancer is a major health concern in China, and awareness of the associated incidence and mortality rates is particularly important given the aging population.

OBJECTIVE

To determine trends in gallbladder cancer incidence and mortality rates over 12 years and quantitatively analyze the influence of demographic factors on these rates in China

METHODS

We performed a retrospective study of 98,860 Chinese citizens using the Chinese Cancer Registry, a national database. Gallbladder cancer incidence and mortality data pertaining to patients treated between 2005 and 2017 were collected. Joinpoint regression models were used to estimate the annual percentage change (APC) and average APC (AAPC). We used age-period-cohort analyses and decomposition methods to investigate differing trends in incidence and mortality.

RESULTS

The age-standardized gallbladder cancer incidence and mortality rates in China trended downward between 2005 and 2017, with AAPCs of -2.023% and -1.603%, respectively. The incidence rate increased with age up to 70 years and peaked at 70–79 years, while the mortality rate showed a consistent increase with age. Both incidence and mortality rates increased in more recent periods; in terms of the cohort effect, rates generally decreased in later birth years but showed a partial rise between 1982 and 1996. The crude incidence rates of gallbladder cancer according to demographic and non-demographic factors were 626.09% and -526.09% respectively (366.23% and -266.23% among men, and 6068.93% and -5968.93% among women, respectively). The rates were 543.01% and -443.01%, respectively, in urban areas and were 68.22% and 31.78%, respectively, in rural areas. The mortality rates according to demographic and non-demographic factors were -495.93% and 595.93%, respectively (-1763.10% and -1863.10% for men and -270.56% and -370.56% for women, respectively). These rates were -930.33% and 1030.33%, respectively, in urban areas and were 101.48% and -1.48%, respectively, in rural areas.

CONCLUSIONS

The overall standardized gallbladder cancer incidence and mortality rates in China are trending downward, but not sufficiently so. Proper living and eating habits should be encouraged while exploring the establishment of long-term, standardized gallbladder cancer screening programs.
Evaluation of Usage and Efficacy of the 656 Online Platform for Reducing Caregiver Stress in Chinese caregivers: Longitudinal Open-trial Study (Preprint)
Authors: Zhang Wen , Lo Ruby , Choi Anna , Wai Ka Chung Abraham , Wong Y.H. Janet
Published: January 2024

BACKGROUND

The informal caregivers of older adults with serious health problems, especially for stroke, dementia, and fracture, are facing numerous caregiving stress. The online platform can be a cost-effective way to support caregivers and reduce their caregiving stress.

OBJECTIVE

This study aimed to assess the efficacy of a new online platform in reducing caregiver stress and enhancing caregiver preparedness and competence of older adults with stroke, dementia, and fracture, investigate the factors influencing the usage of the online platform, and examine user satisfaction and engagement.

METHODS

A longitudinal open-trial study design was applied (N=287) with outcome measures administered at baseline, 3-month follow-up, and 15-month follow-up. Primary outcomes included changes in caregiver stress, caregiver preparedness, and competence. The user profile was explored by comparing the characteristics of participants in user group and non-user group. User satisfaction and engagement were also reported.

RESULTS

Among these included 287 caregivers, 61% of caregivers used online platform and users demonstrated a significant reduction in caring stress, and improvements compared to non-users in competence of caregivers, but there was no significant difference in caregiver preparedness. The user profile that emerged from the survey data showed that younger, full-time employed individuals with upper secondary education or above, average monthly household income of $25,000 or more, and no chronic illness were more likely to use the 656 m-Health Platform. The 15-month FU survey of users revealed high satisfaction levels.

CONCLUSIONS

The online platform can reduce caring stress, improve competence of caregivers, and receive a high level of satisfaction. Additional enhancements may be needed to significantly move the needle on preparatory measures among users, including incorporating more multimedia guidance on practical caregiving preparations.
Study of the Impact of Climatic Changes in 1980–2021 on Railway Infrastructure in the Central and Western Russian Arctic Based on Advanced Electronic Atlas of Hydrometeorological Parameters (Version 2, 2023)
Authors: Gvishiani Alexei , Rozenberg Igor' , Soloviev Anatoly , Krasnoperov Roman , Shevaldysheva Olga , Kostianoy Andrey , Lebedev Sergey , Dubchak Irina , Sazonov Nikolay , Nikitina Isabella , Gvozdik Sofia , Sergeev Vladimir , Gvozdik Georgy
Published: January 2024

Arctic zone of the Russian Federation (AZRF) is the region of intensive economic development. In this regard, it is critical to give an adequate assessment of natural factors that may have a negative impact on the growing technological infrastructure. Rapid climate change effects show a significant influence on this activity, including the railway network development. Hence, the decision-making community requires relevant information on climatic variations that can put at hazard the construction and operation of railway facilities. This paper presents the analysis of climatic changes within the region of Central and Western Russian Arctic in 1980–2021. It was performed using the new electronic Atlas of climatic variations in main hydrometeorological parameters, created for the Russian Railways in 2023. This geoinformatic product includes about 400 digital maps reflecting the variability of seven climatic parameters over more than four decades within the studied region. These parameters are air temperature, total precipitation, wind speed, soil temperature, soil moisture content, air humidity, and snow cover thickness. The analysis of climatic maps and their comparison between selected periods showed spatial and temporal heterogeneity of climatic variations in this region. This justifies the feasibility of further research using additional analytical instruments, such as Hovmöller diagrams, time series graphs, etc. The implementation of advanced geoinformatic products in the practice of the Russian Railways will facilitate sustainable development of its infrastructure in rapidly altering climatic conditions.
FINITE ELEMENT ANALYSIS FOR DYNAMIC RESPONSE OF VISCOELASTIC SANDWICHED STRUCTURES INTEGRATED WITH ALUMINUM SHEETS
Authors: Elmoghazy Yasser Hamed , Safaei Babak , Sahmani Saeid
Published: January 2024

Passive vibration attenuation of modern mechanical structures is one of the most essential technologies applied to the arsenal of modern mechanical structures. In this work, dynamics analysis is performed on viscoelastic (VE) sandwich beam and plate by using finite element method. The proposed structure is composed of a VE core and aluminum face sheets as substrate layers on both sides of the structure. Small-strain VE material is modeled based on complex constant moduli model and numerical method is used to develop the finite element (FE) shear model based on first-order shear deformation theory (FSDT) and Hamilton principle. In modal analysis, model-effective mass analysis is performed to investigate its dominant mode shape and sweet spot at resonance using C3D20 and CPS8 elements. The former is indicated as a 3-D element with 20 nodes while the latter is indicated as a 2-D plane strain element with eight nodes. In harmonic analysis, resonance frequency is obtained based on mode superposition method to evaluate the steady-state response of VE sandwich beam via maximum deformation. Thereafter, the results are compared against analytical solutions from the literature. Moreover, a parametric study shows that the natural frequency of the beam did not change with the increase in core thickness. However, normalized loss factor of VE sandwich beam  is directly proportional to VE damping factor  and the thickness of VE core layer. Based on frequency response function, the results of resonance frequencies for VE beam are in the range of modal natural frequency.
A Problem based on Lagrange Relaxation Approach & Solving Optimization on Bi-level Model Programming Problem
Authors: Raj Anil , Prasad Dr. Krishnandan
Published: January 2024

Abstract: In this paper, a salutation method based on Lagrange relaxation for discrete-continuous bi-level problems, with binary variables in the leading problem, considering the optimistic approach in bi-level programming. Linearized taking advantage of the structure of the leading problem, an algorithm is solving two-dimensional bi-level linear programming problems, classification of constrains, algorithm removes all redundant constraints, cycling and solution of problem.