bluuebunny/crossref_metadata_2025 huggingface dataset:
A multicriteria optimization approach for the stock market feature selection
Authors: Radojicic Dragana , Radojicic Nina , Kredatus Simeon
Published: November 2020

This paper studies the informativeness of features extracted from a limit order book data, to classify market data vector into the label (buy/idle) by using the Long short-term memory (LSTM) network. New technical indicators based on the support/resistance zones are introduced to enrich the set of features. We evaluate whether the performance of the LSTM network model is improved when we select features with respect to the newly proposed methods. Moreover, we employ multicriteria optimization to perform adequate feature selection among the proposed approaches, with respect to precision, recall, and F? score. Seven variations of approaches to select features are proposed and the best is selected by incorporation of multicriteria optimization.
“Counting Carbs to Be in Charge”: A Comparison of an Internet-Based Education Module With In-Class Education in Adolescents With Type 1 Diabetes
Authors: Pais Vanita , Patel Barkha P. , Ghayoori Sholeh , Hamilton Jill K.
Published: November 2020

Carbohydrate counting is an essential component of type 1 diabetes education but can be difficult for adolescents to learn. Because adolescents are avid users of technology, an Internet-based education module was compared with an in-class education session in terms of carbohydrate counting accuracy in adolescents with type 1 diabetes. Adolescent participants displayed increased carbohydrate counting accuracy after attending an in-class education session compared with an Internet-based education module. These results suggest that online education is best reserved as an adjunctive therapy to in-class teaching in this population.
GEODYNAMICS
Authors:   Lviv branch of the Ukrainian State Geological Exploration Institute, Zajats Ch.
Published: November 2020

The new form of Kalush fault for a series of curved planes offset rocks formed by erosion processes, obtained for analysis and pereinterpretats wave pattern of seismic profiles. Searcl the new object of oil and gas perspective in the Neogene within the local rock fragments displacement is recommended.
GEODYNAMICS
Authors:   Institute of Geosphere Dynamics RAS (Mikhnevo), Ivanchenko G. , Horbunova E. M. ,   Institute of Geosphere Dynamics RAS (Mikhnevo)
Published: November 2020

The relationship between the structures of the crystalline basement, structures of the sedimentary cover and relief of the day surface was traced on the basis of the geological and geophysical data and the results of visual and automated interpretation of the satellite images of the central part of East European Platform. Completed research allowed to determine the extent of the neotectonic activity of morphostructures influencing at the formation of the geophysical fields.
GEODYNAMICS
Authors:   Scientific-Research Institute ", Karpenko V.M. ,   Naukanaftogaz", Starodub Yu. P. ,   Lviv State University of Life Safety, Karpenko O.V. ,   Institute of Geophysics of the National Academy of Sciences of Ukraine), Basnyev Ye.O. ,   PAT ,,Ukrnaftohazgheofizyka”
Published: November 2020

Energy-researched analysis of the wave field (ERA-WF) on the example of 3D seismic data Drobyshivska area is investigated. Results of the study are compared with the results of analysis of the wave field, made by the frequency Fourier method, Prony, Gilbert, wavelet functions, and the results of the parametric interpretation of geophysical parameters derived using a software system Petrel. We prove that the ERA-WF summarizes the methods mentioned and allows to determine the geophysical parameters of geological medium (GM) to study it before drilling and well logging concerning oil and gas saturation.
GEODYNAMICS
Authors:   Institute of Geophysics of the National Academy of Sciences of Ukraine), Kendzera O. , Pihulevskyi P. H. ,   Institute of Geophysics of the National Academy of Sciences of Ukraine), Sherbina S.V. ,   Institute of Geophysics of the National Academy of Sciences of Ukraine), Svystun V. K. ,   Dnipro Geophysical Expedition "Dniprogeophysics" (DGE)
Published: November 2020

Summarizes the results of preliminary studies to ascertain the nature of earthquakes and seismic safety in the provision of technologically-risk areas Krivoy Rog iron ore and coal basins Pavlograd. The possibilities of highly sensitive seismic stations UK15, established in Dnepropetrovsk (n. Mirnij), check local and remote Kryvyi Rih and Pavlogradskij earthquakes.
GEODYNAMICS
Authors:   Ivano-Frankivsk National Technical University of Oil and Gas, Kuzmenko E. D. , Bahrii S. M. ,   Ivano-Frankivsk National Technical University of Oil and Gas
Published: November 2020

Research conducted within Kalush-Golinskii potassium salt deposit. The analysis of symmetry systematic approach errors in the geological interpretation is directed. As a result of interpretation revealed that erosion solt mirrors has flat character and should be taken into account in predicting the day surface subsidence. The authors proposed new original approaches to complex interpretation of these methods for mapping geological section.
Large B-Cell Lymphoma with T-Cell–Rich Background and Nodules Lacking Follicular Dendritic Cell Meshworks: A Case Report with Complete Response to Chemotherapy and a Review of the Literature
Authors: Shalata Walid , Massalha Ismaell , Al-Athamen Kayed
Published: November 2020

In this report, we describe a 38-year-old male with a very rare type of lymphoma, large B cell lymphoma with T cell-rich background and nodules lacking follicular dendritic cell meshworks (THRLBCL). In 2016 the patient presented hot flashes and night sweats (B-symptoms) and peripheral edema. He was treated with R-CHOP (doxorubicin, vincristine, cyclophosphamide, rituximab and Prednisone) chemotherapy, a Positron emission tomography–computed tomography (PET-CT) scan was performed after four cycles of treatment which showed radiologic complete response and blood test (complete blood count (CBC)) results showed normal ranges. As of September, 2020 he patient remains in complete remission.
We searched the literature for descriptions of cases spanning the diagnostic spectrum of THRLBCL and we identified only five cases worldwide. The last reported case was in 2014 with distinctive features that were difficult to classify according to the World Health Organization criteria or previously described variants.
Our patient is the sixth case of THRLBCL to be reported. He is the youngest of the reported cases and the first from Israel and the Middle East.
DELINEATION OF SUBSIDENCE IN THE ALTERATION ZONE IN ULUBELU GEOTHERMAL FIELD BASED ON INTERFEROMETRY SYNTHETIC APERTURE RADAR TIME SERIES
Authors: Zaenudin Ahmad , Putra Sofiyadin Ilham Tri , Arief Rachmat
Published: November 2020

Ulubelu is a geothermal region managed by Pertamina Geothermal Energy (PGE) located in Mount Kukusan, Sula, Kabawok, Kuripan and Rindingan. The learning of subsidence is required for disaster mitigation. This research use 33 SAR data of Sentinel1-A which bundled for generate an APS and then using multi temporal analysis to generate InSAR time series from 2018 September to 2017 April. InSAR time series can detect indication of subsidence practically and quickly. Decrease velocity of subsidence in the Ulubelu geothermal region is an average of 3,3 mm/yr (X=453.558, Y=9.412.437, 48 S zone. This subsidence is domination by altered rocks compaction. In the other hand, the geological structure (faults) and lithology also surface loading affected the subsidence. Pekon Gn. Tiga, Karang Rejo, Muara Dua and Pagar Alam are the worst of subsidence area. Mitigation must to be clear early for areas that have the worst subsidence in Ulubelu geothermal field.
Evaluation of the Power Transformer Magnetizing Inrush Currents
Authors:   Tol’yatti State University (TSU), KUVSHINOV Aleksey A. , VAKHNINA Vera V. ,   Tol’yatti State University (TSU), CHERNENKO Aleksey N. ,   Tol’yatti State University (TSU)
Published: November 2020

The mathematical model of a shell-core power transformer’s magnetization branch is substantiated. By using the model, analytical expressions for the magnetizing current instantaneous values under the conditions of geomagnetic disturbances can be obtained. Quantitative assessments of the magnetizing inrush current amplitudes and durations versus the geomagnetic disturbance intensity are obtained. The dynamics of the power transformer magnetic system saturation transient and changes in the magnetization inrush current amplitudes and durations after a sudden occurrence of geomagnetic disturbances are shown. The error of estimating the magnetizing inrush current amplitudes under geomagnetic disturbances is determined based on comparison with experimental data.
An analysis of the statistics used in psychological papers
Authors: Popa Marian
Published: November 2020

This article analyses the statistical procedures used in the proceedings of the one of the psychology conferences regularly organized in Romania. 111 papers in six branches of applied psychology were scrutinized. The analysis was structured on descriptive statistics (numerical and graphical), and inferential statistics (parametric and nonparametric). Was also pursued the extent to which papers complied with APA recommendations on the reporting of confidence limits and size effect. Results: 64.9% of the papers reported statistical results. The sections with more statistical based papers are military psychology (85.7%) and industrial-organizational psychology (84%). On the other hand, only 52.4% papers on educational psychology reported statistics procedures. The average of the reported samples was 190 subjects (minimum 10, maximum 1519). A percentage of 26.4% of works includes at least one statistical descriptive indicator, while 31.9% of works containing statistics, have no descriptive indicators. The graphics used are mostly bar and pie. Regarding inferential statistics, 47.2% of work contains at least one statistical test, and 36.1% have none statistical test. The most frequent utilized tests are Pearson r and t tests. It was recorded no single case of reporting effect sizes and confidence limits. Conclusions: The results allow us to appreciate that the papers presented at scientific events, most of them by young psychologists, contain a relative insufficiently matured statistical analysis, and often insufficient connected to the problem studied. We must appreciate, however, as positive the interest in empirical research and statistical analysis of results.
Build, share and transfer new skills in transnational enterprises: issues and constraints
Authors: Oprea Ciobanu Raluca
Published: November 2020

Following working evolutions of the last decades (delocalization, implantation, globalization), the companies are trying to adapt themselves and develop more and more innovating products. They are trying to anticipate the effects of those mutations in order to develop new organizational models, based on flexibility and structural transversality (Bobillier-Chaumon, 2003). This study determines the way Romanian and French employees construct, gain and transfer new abilities and, most importantly, how they are employing their work and abilities in order to maintain the organization (Engestrom & Middleton, 1998; Rabardel & Samurcay, 2006; Wisner, 1985). We conducted 24 interviews (with Romanian and French employees of a French multinational company) and 2 half-days of workshops in order to understand the nature of the activity in place (processus, vocabulary, working rules, instructions). Our first results focus on the link between the collective and the knowledge transfer, as well as the adjustment of their actions and interventions.
The problem of human resource training for innovation economy in the context of inequality of the Russian regions
Authors: Trofimova Irina Nikolaevna
Published: November 2020

This article explores the differences between major and regional universities from the perspective of human resource training for innovation production. The hypothesis is advanced that these differences are caused first and foremost by concentration of resources in major regions, and therefore, by the advantage of major universities and limited opportunities of regional universities to involve students and postgraduates in innovation activities. The theoretical and methodological framework is comprised by the provisions that reveal complex and contradictory nature of relationship between the economy and higher education, imbalance between the level of production modernization and the level of educational potential characteristic to multiple regions. The novelty of this works consists in articulation of the problem, methodology and utilization of the original empirical base, which represents the results of a survey that involves 90 experts from 15 Russian regions and was conducted in 2017-2019. It is demonstrated that the best regional universities can be competitive in relation to major universities, and reduce the so-called “centrism of the capital” due to more efficient usage of resources and closer ties with local production. An important condition is the competitiveness of human resource training programs, which relies not as much on compliance with formal indexes and positions in different ratings, as by particular results acquired in collaboration with manufacturing companies.
The use of chromosomal microarray for postnatal diagnosis: a retrospective analysis
Authors: Романова И.И. , Канивец И.В. , Пьянков Д.В. , Коростелев С.А.
Published: November 2020

Цель исследования - оценить распространенность и типы хромосомных аномалий у пациентов с множественными врожденными пороками развития (МВПР), комплексами малых аномалий развития (МАР), задержкой развития, умственной отсталостью (ЗР/УО) и расстройствами аутистического спектра (РАС) за период с 2013 по 2019 гг. Методом хромосомного микроматричного анализа (ХМА) было обследовано 6516 пациентов с МВПР, ЗР/УО, РАС и МАР. В результате проведенного анализа причина заболевания была обнаружена у 1212 (18,6%) пациентов, у 4868 (74,7%) пациентов хромосомный дисбаласнс отсутствовал, а 436 (6,7%) пациентов имели варианты, возможно имеющие отношение к причине заболевания. Вывод: Полученные нами результаты указывают на необходимость использования ХМА в качестве теста первой линии, вместо стандартного кариотипирования, в постнатальной диагностике.
Prognostic factors for the success of obtaining spermatozoa with a biopsy of testicular tissue in men with severe forms of pathozoospermia
Authors: Яманди Т.А. , Сафина Н.Ю. , Черных В.Б. , Акуленко Л.В.
Published: November 2020

Приводятся данные обследования мужчин с азооспермией и олигозооспермией тяжелой степени, имеющих и не имеющих микроделеции длинного плеча Y-хромосомы, а также результаты биопсии тестикулярной ткани. Отсутствие делеций региона AZF, отсутствие гипоплазии яичек, а также нормальные показатели ФСГ, ЛГ и ингибина В являются прогностически благоприятными критериями в отношении успешности получения сперматозоидов при биопсии ткани яичка для проведения экстракорпорального оплодотворения (ЭКО).

The article presents the results of a survey of men with azoospermia and severe oligozoospermia, with and without microdeletion of the long arm of the Y chromosome, as well as the results of a testicular biopsy. The absence of deletions of the AZF region, the absence of testicular hypoplasia, as well as normal levels of FSH, LH and inhibin B are prognostically favorable criteria for the success of obtaining spermatozoa with a biopsy of testicular tissue for in vitro fertilization (IVF).
Prescriptions (!!) pour maîtriser la prise de parole en public
Authors: Gaiddon Gérard
Published: November 2020

A défaut de pouvoir bénéficier d’un entraînement et de conseils personnalisés – ce qui est bien entendu le plus souhaitable – le lecteur trouvera ici quelques-unes des notions les plus importantes pour réussir sa prise de parole en public.Il s’agit pour lui de maîtriser rapidement l’essentiel : se familiariser avec les différentes méthodes de préparation, mentale comme émotionnelle, apprendre à gérer au mieux son intervention grâce à une prise de contact adaptée, maîtriser sa communication avec le public, capter son attention, puis la retenir en mobilisant toujours son intérêt.Dans ce but, nous proposons une approche la plus pragmatique possible : une manière de « check-list » que le lecteur pourra aisément mémoriser.Chacun des points abordés ici pourra naturellement être approfondi, complété, enrichi au gré de vos propres expériences, car on n’apprend jamais mieux que par soi-même.

Abstract

Without being able to benefit from training and personalized advice - which is of course the most suitable - the reader will find here some of the most important concepts for delivering successful lectures.It is a matter of quickly mastering the essential: to become familiar with the various methods of preparation, mental as well as emotional, to learn how to manage his / her intervention as best as possible through appropriate contact, to master his/her) communication with the public, to capture his attention, then retain it by always mobilizing its interest.For this purpose, we propose the most pragmatic approach possible: a «checklist» that the reader can easily memorize.Each of the points discussed here can of course be deepened, completed, enriched according to the reader/future speaker’s own experiences, as we never learn better than by ourselves.
The Telemedicine applied to the follow up of patients with End Stage Renal Failure
Authors: SIMON Pierre
Published: November 2020

Abstract

In the 21st century, renal failure is a chronic disease that affects several millions people in France and around 600 millions worldwide. Its prevalence in the general population increases with the lengthening of the life expectancy that characterizes the developed countries and which begins to appear in the developing countries. Chronic hemodialysis is a treatment that saved many children and young adults in the 20th century whose kidneys were destroyed by several infectious and toxic agents and by untreated malignant hypertension. These causes have been controlled by hygiene measures, anti-infective agents or protective pharmacological agents of the cardiovascular system. Today the causes of end stage renal failure are dominated by degenerative diseases due to aging, such as diabetes and chronic vascular disease. The prevention of the worsening of chronic renal failure is now possible due to better control of high blood pressure and diabetes which are the two main causes of kidney destruction. Hemodialysis treatment cannot always be relayed by renal transplantation. Many patients remain on chronic hemodialysis until they die. It is important to adapt the conditions of treatment to the social life of patients affected by this chronic disease so that these are the best possible. This is the goal of telemedicine that allows to remotely monitor the main clinical and biological factors associated with the worsening of the disease. Teledialysis (hemodialysis and peritoneal dialysis) allows to perform dialysis sessions at home or at the nearest in home substitutes (nursing home) or in satellite units of hemodialysis. Similarly, when the patient is transplanted, it makes possible to either lighten or intensify the surveillance according to the risk or not of graft rejection through home teleconsultation.The tools of the digital era such as telemedicine, health connected with connected objects and mobile apps for medical purposes, the performance of which is increasing with the algorithms of artificial intelligence (machine learning, deep learning), can improve the relationship between the patient and his doctor. An ethical reflection must be associated with all these innovations. New exercise of the medicine will be greatly enriched due to medical time more devoted to the relationship with the patient. The new care organizations made possible by digital technologies must be taught to the new generations of nephrologists.
Underutilization of Home Dialysis in the United States: missed opportunities for quality improvement.
Authors: Nguyen Vo D
Published: November 2020

Peritoneal dialysis may offer many potential advantages over in-center hemodialysis: lower cost, better quality of care and lower mortality. However, the United States Renal Data System (USRDS) which is a national data system that collects, analyzes, and distributes information about chronic kidney disease (CKD) and end-stage renal disease (ESRD) in the United States, indicates that the incidence and prevalence of home dialysis remains under-utilized compared with in-center hemodialysis. Future changes in national policy on dialysis may bring about an increase in home dialysis and potentially improve the care and cost in dialysis. This paper is mostly based on the 2017 USRDS Annual Report and centered on the potential missed opportunity caused by the underuse of peritoneal dialysis in the US.
Synthetic 2018 data report of the French Language Peritoneal Dialysis and Home Hemodialysis Registry (RDPLF)
Authors: Verger Christian , Fabre Emmanuel , Veniez Ghislaine , Padernoz Marie Christine
Published: November 2020

The RDPLF was created in 1986 and collects the main data of peritoneal dialysis of French patients and of various French-speaking countries. The database is structured in several modules: a compulsory core module including a follow-up of comorbidities, assistance, infections, survival, transplantation, and optional modules following more specific aspects: nursing, catheter, anemia, nutrition, heart failure. In addition, since 2012 patients treated at home in hemodialysis are also followed. This article presents a summary of the main characteristics of patients in the RDPLF in 2018. It highlights important differences in practices and patient profiles between francophone countries. Daily low dialysate flow rate hemodialysis is predominant in the new centers and sometimes begins to appear as a transitional mode that allows home maintenance for patients who cannot continue on peritoneal dialysis.
Relation between dialysis dose and quality of life of patients on peritoneal dialysis
Authors: AL BORGI Yassine , El Alaoui Amina , Benlachhab Zineb , Toutti Wiam , SaghirBahah Mohamed , Jerghich Khadija , Ghita Bardai , Amal Chouhani Basmat , Kabbali Nadia , El Rhazi Karima , Sqalli Tarik
Published: November 2020

ObjectiveThe interest of our work is to identify the objective parameters that can improve the subjective parameters of the well-being of the patients and to share the experience of the care in our center. Kt / V urea and KDQOL SF 36 scale (Kidney Disease Quality of Life short form 36)were used.

Material and methodsThis is a single-center cross-sectional study conducted in October 2018 among patients treated with peritoneal dialysis, followed for at least six months in the Nephrology Department of Fez University Hospital (Morocco). The quality of life was assessed using the SF-36 (short form) version of the Kidney Disease Quality of Life (KDQOL) scale in its validated Arabic dialect version (1). We used the KDQOL-SF36 results as quantitative variables related to obtaining a Kt / V> 1.7.

ResultsThis study included 17 adult patients on peritoneal dialysis of which 35.3% are on automated peritoneal dialysis (APD) and 64.7% are on continuous ambulatory peritoneal dialysis (CAPD). The mean age is 40.8 ± 5 years and the sex ratio is 9H / 8F.

In bivariate analysis, we found a significant relationship between dialysis dose and social support. This result could be explained by better adherence in patients with better social support.

ConclusionEfforts must be made to achieve the adequacy goals, without losing sight of patients’ quality of life. There is also a need for further studies that include more patients and study other parameters such as clinical evaluation, residual renal function and ultrafiltration.

 

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Réaliser des tableaux de bord avec le logiciel R
Authors: Della Vedova Claire
Published: November 2020

Résumé

NDLR : Le RDPLF a pour but principal d’être une aide pour permettre aux équipes de dialyse à domicile d’évaluer leurs pratiques cliniques et également conduire des études à partir d’exports anonymisés des données qu’elles saisissent. A cette fin, depuis juin 2019, un article de formation à l’utilisation du logiciel Libre R est publié trimestriellement à chaque parution du Bulletin de la Dialyse à Domicile. Le but est de permettre à toutes les équipes de réaliser des statistiques de bases et visualiser rapidement leur données.

Le premier article de cette série d’initiation était consacré au téléchargment et à l’installation du logiciel R sur les ordinateurs Macintosh et PC : https://doi.org/10.25796/bdd.v2i2.20513 .

Le second article était consacré à la visualisation graphiques des données statistiques avec le package Esquisse, simple d’utilisation et nécessitant peu d’apprentissage : https://doi.org/10.25796/bdd.v2i3.21313 Le troisième article était consacré à la visualisation graphiques avec le Package ggplot2 : https://doi.org/10.25796/bdd.v2i4.52303

Le quatrième article expliquait comment générer un rapport d’analyse automatiquement, et de façon dynamique, en utilisant “Rmarkdown” : https://doi.org/10.25796/bdd.v3i1.54523

Ce cinquième article est consacré à la manipulation des données avec le package dplyr : https://doi.org/10.25796/bdd.v3i1.54523

Comme dans les numéros précédent un fichier exemple, tiré de la base de données du RDPLF sera utlisé.

Biographie de l'auteur

Claire Della Vedova, 1087 chemin de Sainte Roustagne, 04100 MANOSQUE, France

Claire Della Vedova est Ingénieure en biostatistique / data analyste, Elle utilise quotidiennement le logiciel R pour analyser des données. Elle a travaillé pendant plus de 15 ans dans les domaines de l’environnement et de la santé, et a formé de nombreux étudiants et chercheurs à l’utilisation de R. Elle anime depuis novembre 2017 le blog Statistique et Logiciel R dont le but est d’aider les débutants à mieux appréhender les méthodes statistiques classiques et à utiliser le logiciel R plus efficacement, notamment au travers de tutoriels : https://statistique-et-logiciel-r.com/.
Non-invasive assessment of peritoneal membrane alterations
Authors: Krediet Raymond , Parikova Alena
Published: November 2020

The peritoneal dialysis membrane is subject to remodelling in the course of peritoneal dialysis. In the absence of longitudinal morphological studies, this process is mainly studied indirectly by the investigation of changes in peritoneal transport. Non-invasive assessment of the peritoneum is also possible by assessment of substances that originate from peritoneal tissues and can be determined either as their gene expression in peritoneal effluent cells and/or as proteins in peritoneal effluent. Three of these biomarkers will be discussed, because longitudinal data are available.

Cancer antigen 125 (CA 125) is present on the mesothelium,while its gene (MUC 16) is expressed in peritoneal effluent cells and is related to dialysate CA 125 protein. The constitutive production and the small intra-individual variability of 15% indicate its usefulness as a follow-up marker of mesothelial cell mass. Dialysate appearance rate is higher on biocompatible than on conventional solutions, but both decrease during long-term follow-up.

Interleukin-6 (Il-6) is present in peritoneal effluent due to both transport from the circulation and local intraperitoneal production. Its appearance rate is unrelated to its gene expression in peritoneal cells. The intra-individual variation of effluent Il-6 averages 28%, hampering the interpretation of cross-sectional values. The relationships between effluent Il-6 and peritoneal transport have been interpreted as microinflammation, but are difficult to interprete due to mathematical coupling.

Plasminogen activator inhibitor-1 (PAI-1) is encoded by the SERPINE 1 gene. A relationship is present between effluent concentration and gene expression. PAI-1 production is stimulated by glucose. PAI-1 appearance rate increases with PD duration. The sensitivity of effluent PAI-1 for the diagnosis of encapsulating peritoneal sclerosis was 100% one year prior to the diagnosis and the specificity 56%.

It can be concluded that the discussed biomarkers are useful extensions to transport in assessment of the peritoneum during dialysis.
Biodiesel Production from Sunflower Oil Using K2CO3 Impregnated Kaolin Novel Solid Base Catalyst
Authors: Jalalmanesh Shayan , Kazemeini Mohammad , rahmani mohamad hosein , zehtab milad
Published: November 2020

Kaolin clay material was loaded with potassium carbonate by impregnation method as a novel effective and economical heterogeneous catalyst for biodiesel production of sunflower oil via the transesterification reaction. The structural and chemical properties of the produced catalysts were analyzed by several characterization tests including the BET-BJH, XRD, SEM and FTIR. Influence of the K2CO3 impregnation level was examined by comparing the catalytic activity of different produced catalysts. To expand the efficiency of transesterification reaction, parameters of reaction were optimized including; the molar ratio between methanol and oil, concentration of catalyst, and duration of the reaction. The highest yield of biodiesel over the K2CO3/kaolin catalyst was around 95.3 ± 1.2%. It was achieved using kaolin supports impregnated with 20 wt.% of K2CO3. The optimum reaction conditions were found to be catalyst reactor loading of 5 wt.%, reaction temperature of 65 °C, methanol: oil molar ratio of 6:1 and reaction duration time of 4 h.
Struct2IUPAC -- Transformer-Based Artificial Neural Network for the Conversion Between Chemical Notations
Authors: Krasnov Lev , Khokhlov Ivan , Fedorov Maxim , Sosnin Sergey
Published: November 2020

Providing IUPAC chemical names is necessary for chemical information exchange. We developed a Transformer-based artificial neural architecture to translate between SMILES and IUPAC chemical notations: Struct2IUPAC and IUPAC2Struct. Our models demonstrated the performance that is comparable to rule-based solutions. We proved that both accuracy, speed of computations, and the model's robustness allow us to use it in production. Our showcase demonstrates that a neural-based solution can encourage rapid development keeping the same performance. We believe that our findings will inspire other developers to reduce development costs by replacing complex rule-based solutions with neural-based ones. The demonstration of Struct2IUPAC model is available online on Syntelly platform https://app.syntelly.com/smiles2iupac
Real Space Delocalization, Resonance and Aromaticity
Authors: Reuter Leonard , Lüchow Arne
Published: November 2020

When chemists want to explain a molecule’s stability and reactivity, they often refer to the concepts of delocalization, resonance, and aromaticity. Resonance is commonly discussed within the electronic structure framework of valence bond theory as the stabilizing effect of mixing different Lewis structures. Yet, most computational chemists work with delocalized molecular orbitals, which are also usually employed to explain the concept of aromaticity, a special kind of ring delocalization that shows up in cyclic planar systems which abide certain number rules. As an intuitive picture for aromaticity, an electronic ring current has been hypothesized. However, all three concepts lack a real space definition, that is not reliant on orbitals or specific wave function expansions. Here, we outline a redefinition from first principles: the concepts are of kinetic nature and related to saddle points of the all-electron probability density |Ψ|². Delocalization means that likely electron arrangements are connected via paths of high probability density in the many-electron real space. In this picture, resonance is the consideration of additional electron arrangements, which offer alternative paths of higher probability. Most notably, the concept of aromatic ring currents in absence of a magnetic field is rejected and the famous 4n+2 Hückel rule is derived from nothing but the antisymmetry of fermionic wave functions. The analysis developed in this work allows for a quantitative discussion of important chemical concepts that were previously only accessible qualitatively or restricted to specific electronic structure frameworks.
Treatment of metabolic syndrome in young patients with vitamin D deficiency
Authors: Alekseeva N. S.
Published: November 2020

Aim.The purpose of the study is to increase the effectiveness of treatment of metabolic syndrome (MS) in young patients with vitamin D deficiency.
Materials and methods.The study involved 54 patients with MS and vitamin D deficiency (50% of women, 50% of men), aged 2044years. To assess the concentration of melatonin at a young age, a control group of 42 practically healthy volunteers with comparable demographic characteristics with no signs of MS was formed.
Results.In patients with MS and vitamin D deficiency, there was a significant decrease in the average daily level of 6-sulfatoxymelatonin in the urine by 3.7 times, compared with the group of individuals without MS. Patients with MS and vitamin D deficiency (n=54) were randomly assigned to two groups with comparable clinical and demographic characteristics. Patients of the 1st group (n=27) observed dietary recommendations and took the drug Metformin at a dose of 1700 mg/day for 12 months. In the 2nd group (n=27), in addition to the one indicated in the 1st treatment group, correction of vitamin D deficiency was performed (a micelled preparation of cholecalciferol at a dose of 4000 IU/day, for 6 months, then 2000 IU/day for another 6 months) and the level of melatonin (melatonin preparation at a dose of 3 mg/day for 6 months). After treatment in young patients with MS, there was a significant change in the median of the studied parameters in all therapeutic groups, but more pronounced dynamics was observed in group 2 in terms of: WC in women, BMI, insulin resistance index, LDL cholesterol, TG, hs-CRP, hs-TNF-, IL-6, leptin.
Conclusion.To increase the effectiveness of MS treatment in young patients with vitamin D deficiency, it is necessary to determine the level of melatonin (urinary 6-sulfatoxymelatonin) and, if it decreases, carry out correction of melatonin and 25 (OH) vitamin D in addition to the standard therapy of this syndrome.
Dynamic changes of renin-angiotensin-aldosterone system parameters after surgery of primary hyperparathyroidism
Authors: Dobreva E. A. , Bibik E. E. , Eremkina A. K. , Ajnetdinova A. R. , Nikankina L. V. , Malysheva N. M. , Mokrysheva N. G.
Published: November 2020

Aim.To study an activity of the Renin-Angiotensin-Aldosterone System (RAAS) components in patients with primary hyperparathyroidism (PHPT) before and after parathyroidectomy (PTE). Materials and methods.A comparative study of patients with PHPT and control group. The first stage of the study included 56 patients with PHPT (group 1) before and on the third day after PTE. The second stage was carried out in 27 patients with remission of PHPT (group 2). All patients and healthy volunteers were tested for the main parameters of phosphorus-calcium metabolism and the RAAS parameters (plasma renin activity PRA, serum aldosterone, angiotensin II AT II). Results.Patients with active PHPT demonstrated changes in RAAS activity (lower PRA, higher AT II level) comparing to control group, that have statistical significance in group 1 (p0.001 for both parameters). There were no significant differences in aldosterone levels (p1=0.090;p2=0.140). On the third day after PTE (group 1), a decrease in aldosterone level (p=0.009) and a tendency to decrease in PRA (p=0.030) were detected. However, an increase in PRA (p=0.018), a decrease in AT II concentration (p=0.032) comparing to the initial values and their normalization were observed 12 months after surgery when permanent normal serum calcium and PTH levels had been achieved. There were controversial correlations between the parameters of phosphorus-calcium metabolism and RAAS. The influence of angiotensin-converting-enzyme inhibitors and AT II receptor blockers on phosphorus-calcium metabolism in patients with PHPT was not observed. Conclusion.In patients with PHPT, there were no сlear correlations of phosphorus-calcium metabolism parameters with RAAS, however an increase of AT II concentration was noted, that can take part in a development of hypertension for this endocrinopathy. PTE can have a positive effect on AT II level.
Heart arrhythmias and conduction disorders in patients with acromegaly: the role of cardiac magnetic resonance imaging
Authors: Melkozerov K. V. , Przhiyalkovskaya E. G. , Tarbaeva N. V. , Almaskhanova A. A. , Kuklina M. D. , Alferova P. A. , Gomova I. S. , Belousov L. A. , Belaya Z. E. , Vorontsov A. V. , Kalashnikov V. Y.
Published: November 2020

Cardiovascular complications including arrhythmias and cardiac conduction disorders are one of the main reasons of high mortality rate in acromegaly, while they have not been well explored.
Aim.To estimate arrhythmias frequency in acromegaly, identify risk factors leading to the development of arrhythmia and cardiac conduction disorder, to determine the role of cardiac MRI in detecting structural and functional changes.
Materials and methods.A single-center prospective cohort study, which included 461 patients (151 men and 310 women) with acromegaly, was conducted. All the patients underwent a standard medical examination, including hormonal blood test, electrocardiogram, echocardiography, electrocardiogram daily monitoring. 18 patients with arrhythmias (11 men and 7 women) had cardiac MRI with gadolinium-based contrast.
Results.The results of our research show high frequency of arrhythmias and cardiac conduction disorders in patients with acromegaly 42%. Most frequent kinds of arrhythmias and cardiac conduction disorders were sinus bradycardia 19.1% of the cases and conduction disorders of bundle branch blocks 14.5%. Men were more likely to suffer from arrhythmias and cardiac conduction disorders than women (54.2% and 37.4%, respectively,p=0.0005). Not acromegaly activity but duration of the disease was a main risk factor of arrhythmias and cardiac conduction disorders. Patients with arrhythmias had a long anamnesis of acromegaly (10 and 7 years, respectively, p=0.04). Meanwhile, cardiac conduction disorders were commonly observed in the patients who were treated with somatostatin analogs comparing to the patients who didnt undergo this therapy (50% and 38.6% respectively,p=0.004). We showed that 61% of patients with acromegaly and cardiac conduction disorders who underwent magnetic resonance imaging (MRI) had the signs of myocardial fibrosis. The value of the ejection fraction of the left ventricle according to MRI was higher than with echocardiography (p=0.04).
Conclusion.Arrhythmias and cardiac conduction disorders are often observed in patients with acromegaly even with remission of the disease. High risk group need careful diagnostic and monitoring approaches. Cardiac MRI is the gold standard for visualization of structural and morphological changes in the heart. Use of cardiac MRI in acromegalic patients expands our understanding of arrhythmias and cardiac conduction disorders in this disease. There are no specific laboratory markers of diffuse myocardial fibrosis, and the role of myocardial fibrosis in the occurrence of cardiac arrhythmias and conduction disorders needs further studying.
Ovarian endometriosis associated infertility: a modern view to the problem
Authors: Orazov Mekan R. , Khamoshina Marina B. , Abitova Marianna Z. , Mikhaleva Lyudmila M. , Volkova Snezhana V. , Aryutin Dmitry G. , Shustova Victoria B.
Published: November 2020

This review summarizes current understanding of the pathogenesis of one of the most common forms of external genital endometriosis ovarian endometriomas. Due to their frequent occurrence in young women of reproductive age and extremely negative impact on the morphophysiological state of the ovaries, this disease makes a significant contribution to the structure of endometriosis-associated infertility. The main determinant of the negative effect of ovarian endometriomas on reproductive function is a decrease in ovarian reserve, which can occur either due to the direct gonadotoxic effect of the endometriod cyst itself, or due to the unintentional removal of healthy ovarian tissue during surgery or the use of aggressive methods of electrosurgery. Hence, the question of methods for achieving hemostasis during surgery in terms of iatrogenic effects on healthy ovarian tissue is debatable. The management strategy for patients with infertility associated with ovarian endometriosis consists of two components: surgical treatment and/or the use of assisted reproductive technologies. Laparoscopic cystectomy is indicated for cysts larger than 3 cm. Repeated surgical interventions in case of endometriosis do not improve fertility outcomes. Assisted reproductive technologies methods should be considered as a priority tactic in patients of older reproductive age with low ovarian reserve indicators or infertility duration of more than 2 years, as well as in cases of recurrent ovarian endometriomas. Management of such patients must be personalized and take into account the age, state of the ovarian reserve, duration of infertility, stage and number of surgical interventions for this disease.
Short-duration splice promoting compound enables a tunable mouse model of spinal muscular atrophy
Authors: Rietz Anne , Hodgetts Kevin J , Lusic Hrvoje , Quist Kevin M , Osman Erkan Y , Lorson Christian L , Androphy Elliot J
Published: November 2020

Spinal muscular atrophy (SMA) is a motor neuron disease and the leading genetic cause of infant mortality. SMA results from insufficient survival motor neuron (SMN) protein due to alternative splicing. Antisense oligonucleotides, gene therapy and splicing modifiers recently received FDA approval. Although severe SMA transgenic mouse models have been beneficial for testing therapeutic efficacy, models mimicking milder cases that manifest post-infancy have proven challenging to develop. We established a titratable model of mild and moderate SMA using the splicing compound NVS-SM2. Administration for 30 d prevented development of the SMA phenotype in severe SMA mice, which typically show rapid weakness and succumb by postnatal day 11. Furthermore, administration at day eight resulted in phenotypic recovery. Remarkably, acute dosing limited to the first 3 d of life significantly enhanced survival in two severe SMA mice models, easing the burden on neonates and demonstrating the compound as suitable for evaluation of follow-on therapies without potential drug–drug interactions. This pharmacologically tunable SMA model represents a useful tool to investigate cellular and molecular pathogenesis at different stages of disease.
Annealed effects of poly- o- toluidine (POT) nanomaterial at different temperatures
Authors: Priyanka  S  , Dhachanamoorthi N  , Nandhin M
Published: November 2020

Poly-O-Toluidine (POT) nanomaterials were prepared by using chemical oxidative polymerization method. The polymerization process was carried out using the monomer o- toluidine (1M), ammonium peroxydisulphate (APS) (0.5M) as oxidant and the dopant sulphuric acid (3M). The resultant polymer materials are heat treated at various temperatures such as 200°C, and 400°C. The prepared POT materials are characterized by using different Spectroscopic techniques, Fourier Transform Infrared Spectroscopy (FTIR), Ultraviolet Visible (UV-VIS) Spectrometry, Particle Size Analyser (PSA), and biological application like Anti-Bacterial activities. The FTIR study shows the various functional groups in POT. The optical properties of prepared polymer material band gap, electron transition are calculated by using UV-VIS techniques. The PSA studies are revealed that the measurement of the size distribution of individual particles in a POT nanomaterials. The antibacterial activity of the POT nanomaterials are indicates that the several microorganisms. These POT nanomaterials are used to examines that the Chemical, optical, size of the nanomaterials and antibacterial activity for different Bactria.
Ensino híbrido: limites e possibilidades para o ensino de geografia - memórias e relatos docentes
Authors: Gandra Aline Silva Buter , Borges Vilmar José
Published: November 2020

O objetivo deste artigo é discutir os desafios encontrados nas práticas voltadas para o ensino híbrido na disciplina de Geografia em escolas públicas estaduais de Educação Básica no município de Serra – ES. Para tanto, apoiados na metodologia de pesquisa da História Oral Temática (BOM MEIHY, 1996), tomamos narrativas de duas professoras, no intuito de desvelar as perspectivas, limites e possibilidades de utilização desta metodologia. Procuramos entre os autores Moran (2015), Bacich, Tanzi Neto e Trevisani (2015) e Prensky (2010) contribuições teóricas para subsidiar nossas reflexões acerca das potencialidades do ensino híbrido como alternativa metodológica para o processo ensino-aprendizagem de Geografia. A pesquisa sinaliza que o ensino híbrido abre múltiplas possibilidades de trabalhar com as metodologias ativas, colocando o aluno como protagonista do seu processo de aprendizagem.
Review of pathological index detection and new rehabilitation technique of drug addicts
Authors: Yang Banghua , Gu Xuelin , Gu Chao , Xu Ding , Fan Chengcheng
Published: November 2020

There are two major research issues with regard to detoxification; one is pathological testing of drug users and the other is rehabilitation methods and techniques. Over the years, domestic and foreign researchers have done a lot of work on pathological changes in the brain and rehabilitation techniques for drug users. This article discusses the research status of these two aspects. At present, the evaluation of brain function in drug addicts is still dominated by a single electroencephalography (EEG), near-infrared spectroscopy (NIRS), or magnetic resonance imaging scan. The multimodal physiological data acquisition method based on EEG–NIRS technique is relatively advantageous for actual physiological data acquisition. The traditional drug rehabilitation method is based on medication and psychological counseling. In recent years, psychological correction (e.g., emotional ventilation, intelligent physical and mental decompression, virtual reality technique and drug addiction suppression system, sports training, and rehabilitation) and physical therapy (transcranial magnetic stimulation) have gradually spread. These rehabilitations focus on comprehensive treatment from the psychological and physical aspects. In recent years, new intervention ideas such as brain–computer interface technique have been continuously proposed. In this review, we have introduced multimodal brain function detection and rehabilitation intervention, which have theoretical and practical significance in drug rehabilitation research.