bluuebunny/crossref_metadata_2025 huggingface dataset:
How Do Santri, Local Wisdom, and Digital Transformation Affect Community Empowerment?
Authors: Kunaifi Aang , Fikriyah Khusnul , Aliyah Dewi
Published: December 2021

Santri is an unique person in a various economic activities. In the mix of local wisdom that is thick with spiritual values and wrapped in the dynamics of the use of digital technology, students are seen as having a real influence in realizing community empowerment in the economic field. This article aims to describe the role of santri through local wisdom and the use of digital technology in creating community empowerment. To get accurate and up-to-date information, observations and collect information has done by interviewed to santri about their strategies in dealing with economic problems in the regency as well as tips on utilizing digital technology. Furthermore, the information is checked with primary sources in the form of community members to measure the effectiveness of the role of the santri. The analysis and discussion of the data was carried out qualitatively with the phenomenological approach of the Madurese community. The research findings in this article show that there is a collaboration of the attitude and mentality of students in the midst of society with personal capital of independence, honesty, and work ethic. In terms of using digital technology, they are also able to adapt quickly and precisely. Thus, this research is expected to be able to provide a complete and accurate description of the existence and role of santri in creating community empowerment in the economic field, so that regulatory and policymakers can determine priorities in regional and national development.
Creative Village Planning in an Effort to Support the Realization of Creative City
Authors: Islah Khikmatul , Susetyo Ivan Budi , Santiko Aryo
Published: December 2021

Population growth that continues to increase without being balanced with the extent of urban land causes an uncomfortable environment for all its society or communities. People need a chance to have a better life. Something new is required to solve this problem. One of the solutions is to create a Creative Village (Kelurahan Kreative), also as a form of support in realizing the Creative City. This study uses qualitative research with a literature study in data collection. The results show that this Creative Village can run with support from various parties; government, society, and the private sector. The collaboration of various parties will facilitate in realizing creative villages, which can be done by empowering the younger generation who are members of Karang Taruna (youth group). This young generation will move and develop the Creative Village. To support them, at first these young men will get various training as provisions. The use of technology is also important in efforts to realize Creative Village that will further support the creation of Creative City.
The Role of Journalists in Building Optimism in the Small Industry Community During the Corona Pandemic (Study: Formation of a Post For Journalists Covering Covid-19 for the South West Region of Aceh)
Authors: Muzakkir Muzakkir , Alisman Alisman , Maulina Putri , Ikhsan Ikhsan
Published: December 2021

The coronavirus pandemic has made some small industrial communities complain, plus there is confusing news information so that some people feel nervous in dealing with the spread of the coronavirus. The study in this research is basically field research (field research) and literary (library research), with a historical and multidisciplinary approach. Existing data, the authors analyze using a comparative method in a qualitative paradigm, through snowball sampling. Through this method, researchers hope to collect information needed by the small industrial community, so that they are motivated and enthusiastic in moving their business in the midst of the Corona pandemic. The role of the media is not only to report but also to deny hoax information and untrue information, moreover, the media has an important and strategic role in following the development of reliable information related to Covid-19 reporting, as a trusted source for the community towards the era of adaptation of new habits (new normal). ). The presence of journalists presenting news about aid programs, business opportunities, and product marketing facilities for small industry players in circulation and online is one of the breakthroughs that can foster new optimism and hope (expectations) among small industry players in the midst of their business slump due to the pandemic. corona. The final goal of this study, the author tries to get a concrete picture of the roles and responsibilities of journalists in building the optimism of the small industrial community during the corona pandemic.
Engagement e conteúdo em vídeos sobre a aplicação de online dating Tinder no YouTube
Authors: Sepúlveda Rita
Published: December 2021

As soluções de online dating têm-se diversificado e crescido em número de utilizadores, potenciadas principalmente pelas aplicações móveis. Entre estas, a aplicação Tinder tem sido objeto de atenção pela imprensa generalista e de estudo pela academia, devido a um conjunto de características distintivas que têm levantado várias questões. Esta investigação propõe uma abordagem metodológica no sentido de compreender que narrativas relativas à aplicação e aos seus utilizadores são disseminadas no YouTube. O YouTube tem-se revelado uma plataforma importante na disseminação de narrativas sobre diversas temáticas, permitindo a partilha de conteúdo próprio. Para tal, e com recurso a métodos digitais, foi realizada uma análise quantitativa e qualitativa aos vídeos no YouTube mais influentes sobre o Tinder. Os resultados mostraram que estes retratavam fases do processo de online dating como a de criação do perfil, a de correspondência e a de descoberta, refletindo sobre controvérsias associadas à aplicação e sustentando- as. A criação dos vídeos era, na maior parte das vezes, impulsionada pela curiosidade sobre o Tinder e como objeto para criar conteúdo atrativo para a audiência.
AGGRESSION AND EMOTIONAL INTELLIGENCE AS PREDICTORS OF PHUBBING
Authors: Parmaksız İzzet , Kılıçarslan Suat
Published: December 2021

Our skills and attitudes have an effect on our behaviors. Phubbing, which is described as ignoring the interlocutor during communication by focusing on the cellphone, is also highly effective in our behaviors. In this context, this study aimed to determine the predictive effect of aggression and emotional intelligence on the level of phubbing. The study group consisted of 768 adult individuals [Female:461, Male:307] living in different provinces of Turkey. Participants’ ages ranged from 22 to 57. The data of the study were collected using the Phubbing Scale, KAR-YA Aggression Scale, Emotional Intelligence Scale, and a personal information form. According to the findings obtained from the study, there was a significant negative relationship between phubbing and emotional intelligence, a significant positive relationship between phubbing and aggression, and a significant negative relationship between aggression and emotional intelligence. According to the preliminary analysis, sex did not cause a significant difference in phubbing scores, while marital status and level of education caused a significant difference. According to the results of the hierarchical regression analysis, emotional intelligence and aggression were found to be predictors of phubbing behaviors. The research findings were discussed under the literature, and some recommendations were made.
DIGITAL TECHNOLOGY USE OF KINDERGARTEN TEACHERS FOR PARENTAL INVOLVEMENT: E-NVOLVEMENT IN THE TURKISH CONTEXT
Authors: Konca Ahmet Sami , Hakyemez-Paul Sevcan
Published: December 2021

The primary research aim of this current study was to better understand the digital technology use of Turkish kindergarten teachers in their parental involvement practices. A questionnaire designed by the authors was administered to 100 kindergarten teachers in five cities located within Turkey. It was revealed in the study results that the kindergarten teachers owned a variety of electronic devices and used those devices for both personal and educational purposes within the early childhood education setting. Teachers used digital technologies for their parental involvement practices less than they did for their own personal use or for other activities within the educational setting. The parental involvement types where teachers most often used digital technologies were for parenting and communicating. While the least popular parental involvement types where kindergarten teachers used digital technologies were decision-making and collaborating with the community. Teachers mentioned the two most common reasons for insufficient technology use for parental involvement were the parents’ financial status and level of knowledge. A negative relationship between teachers’ personal technology use and experience in the field increased, they were less likely to encounter problems regarding digital technology use for parental involvement
THE USE OF TRAVEL BLOG WRITING IN A TERTIARY LEVEL ENGLISH FOR SPECIFIC PURPOSES COURSE
Authors: Kemaloğlu-Er Elif
Published: December 2021

Blogs can be used as constructive means in EFL teaching allowing learners to exert control over their own writing and enabling them to communicate with the global community of internet users. Among different types of blogs, travel blogs can be employed as pedagogical means for real life based learning and L2 writing improvement. Through travel blogs, learners can both explore different places and write about their travel experience in L2. However, the use of travel blog writing in teaching English for Specific Purposes (ESP) has not yet been investigated. In this study, travel blog writing was integrated into a tertiary level ESP course aiming to improve learners’ linguistic skills in the fields of tourism and travel. The research investigates the learners’ views about blog writing as a part of their ESP course through a questionnaire and interviews. According to the findings, travelling and writing about the tourist attractions of one’s city via a personalized blog was found to increase writing motivation but the experience was also defined to be demanding as it requires heavy workload. Overall, this experience was reported to enhance autonomous, reflective and collaborative learning, increase cultural awareness and contribute to learners’ self-expression and L2 writing improvement.
TEACHERS’ METAPHORIC PERCEPTIONS OF COVID-19 AND SCHOOL IN THE PROCESS OF COVID-19
Authors: Ulaş Suat Deniz , Kurt Halil İbrahim , Bayındır Sezgi , Cihan Özgül , Vural Ömer Faruk , Başaran Mehmet
Published: December 2021

The study aims to reveal teachers’ perceptions of “Covid-19” and “School in the Covid-19 Process” through metaphors. The differences between the covid-19 perceptions of those who had Covid-19 disease in the participants’ families and those who did not were examined. Phenomenology design, one of the qualitative research methods, was used in the study. Participants consist of a total of 100 teachers, 80 in Hatay and 20 in Gaziantep. The content analysis method was used. It was seen that teachers had 45 different metaphors in the perception of ‘Covid-19’ and were collected in eight categories. The most produced metaphors’ codes related with covid-19 were “Flu”, “Cancer”, “Illness”, “War”, “Flu-pneumonia”. Categories created according to metaphors were “Similar to other diseases”, “Infectiousness”, “Damaging”, “Fatal”, “Uncertainty”, “Social order”, “Immunity”, “Isolating”. Participants created 56 different metaphors in the perception of “School in the Covid-19 Process,” and these metaphors could be gathered in seven categories. The most produced metaphors were “Dangerous zone”, “Abandoned building”, “Pandemic point / Virus slot”, “House”.
Cost Effectiveness Analysis of Antipsychotic Medications in the Management of Schizophrenia in Benin City
Authors:   Department of Pharmacy, Federal NeuroPsychiatric Hospital, P.M.B 1108, Benin City, Nigeria., Edefo J.W. , Usifoh S.F. ,   Department of Clinical Pharmacy and Pharmacy Practice, University of Benin, P.M.B 1154, Benin City, Nigeria, Udezi A.W. ,   Department of Clinical Pharmacy and Pharmacy Practice, University of Benin, P.M.B 1154, Benin City, Nigeria
Published: December 2021

Background: Studies on cost effectiveness analysis (CEA) of typical versus atypical antipsychotics in the management of schizophrenia are still lacking in Nigeria thus the objectives of this study are to determine which of the class of antipsychotics is more cost-effective as well as the impact of socio-demographic factors on the response rate to antipsychotics. Method: The effectiveness was measured by Brief Psychiatric rating scale (BPRS) and costs were in Nigerian naira (NGN). The impact of different socio-demographics on the mean BPRScore ± Standard deviation (SD) reduction was determined. The study was conducted from patient’s perspective with decision tree analysis model using two-way sensitivity analysis. The model was used to explore incremental cost effectiveness ratios (ICER) of oral antipsychotic medications Haloperidol /Trifluoperazine versus Olanzepine /Risperidone over a 24-week study period. Results: Cost effectiveness analysis with 1st scenario sensitivity test of medications, trifluoperazine 17.81±2.51mg is more cost effective than olanzapine 10mg, while haloperidol 10mg is more cost effective than risperidone 3.5± 0.51mg. In the second scenario of sensitivity analysis, olanzapine is more cost effective than trifluoperazine only when the savings of making one person free from schizophrenia in a month is worth more than NGN537 while risperidone is more cost effective than haloperidol only when the savings of making one person free from schizophrenia in a month is worth more than NGN2524.1. The effect on response rate to antipsychotics gave p=0.0251, P=0.009, P<0.0001 for educational status, income, stable relationship respectively. Conclusion: Atypical antipsychotic medications are not more cost effective compared to the typical antipsychotics. Higher educational level, income and stable relationship positively affected the outcome of effectiveness of antipsychotics.
Viral Hepatitis B Infection among Undergraduate Students Accessing Health Services at Public Tertiary Institution in Kwara South, Nigeria
Authors:   Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria, Bello S.I. , Williams F.E. ,   Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria, Aliyu F.O. ,   Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria, Ojieabu W.A. ,   Department of Clinical Pharmacy and Biopharmacy, Faculty of Pharmacy, Olabisi Onabanjo University, Shagamu, Nigeria, Adewumi M.A. ,   Department of Clinical Pharmacy and Pharmacy Practice, Faculty of Pharmaceutical Sciences, University of Ilorin, Ilorin, Nigeria
Published: December 2021

Background: Hepatitis B virus (HBV) has been a major public health concern causing above a million deaths worldwide. The disease can be averted by employing relevant screening programs and effectual vaccines. Objectives: This research aimed to assess the occurrence and risk factors for infection of HBV among undergraduate students accessing health services at University of Ilorin, Ilorin, Nigeria. Method: A cross-sectional study was conducted between 15th February and 4th June, 2019. One hundred and eighty-one students were recruited and tested for Hepatitis B surface antigen (HbsAg) with the use of Micropoint Diagnostics Kit, Nantong, China. A validated questionnaire was used to capture information on socio-demographics and risk factors for infection of HBV of the consenting volunteers. Ethical approval with number UIL/UHS/TW was obtained. Statistical Package for Social Sciences was used to analyze the data collected for descriptive and inferential statistics. Results: The mean age of the students was 19.21± 5.37 years with the majority being females 110 (60.8%). Ten students tested positive for HBV giving an incidence rate of 5.5%. The age of the students showed a significant association with HBV positivity. Use of injectable illicit drugs and sharing of utensils were the behavioural risk factors that correlated with HBV infection. Conclusion: The incidence rate of HBV disease was intermediate and the risk factors identified were age, use of injectable illicit drugs and sharing of utensils. Proper adherence to prevention and control measures coupled with efficient follow-up could decrease the occurrence of the disease.
Knowledge of Prevention and Management of Childhood Diarrhoea among Nigerian Mothers: A Public Health Survey
Authors:   Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Nigeria, Ayogu E.E. , Ubaka C.M. ,   Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Nigeria, Ukwe C.V. ,   Department of Clinical Pharmacy and Pharmacy Management, Faculty of Pharmaceutical Sciences, University of Nigeria, 410001, Nsukka, Enugu State, Nigeria
Published: December 2021

Background: Diarrhoea accounts for 1,300 deaths every day globally. Mothers’ knowledge of preventive measures and practices in the management of childhood diarrhoea influences the disease’s morbidity and mortality. Objectives: This study assessed the knowledge of, and practices mothers adopt in childhood diarrhoea prevention and management. Methods: A cross sectional study was carried out among mothers in five rural communities in South-Eastern Nigeria using pretested questionnaires. Completed questionnaires were subjected to descriptive and associative analysis. Results: Two thirds of the mothers surveyed (N=374; 67.9%) had poor knowledge of diarrhoea. Less than half mentioned a good hygienic environment (33.5%) as being essential to keeping diarrhoea at bay, 16.5% boiled their drinking water while 70.9% could not prepare a simple oral rehydration solution (ORS) correctly. Two out of ten mothers (20.6%) used an antibiotic in the treatment of diarrhoea and 27% visited the hospital only when the child became very weak. Mother’s occupation (P = 0.002) and her monthly income (P = 0.004) significantly affected their knowledge while age, monthly income and level of education significantly influenced their practices (P<0.05). A higher knowledge of diarrhoea was significantly associated with better feeding practice (P = 0.0001) and correct actions taken to treat diarrhoea (P = 0.003). Conclusion: Most of the mothers surveyed had poor knowledge about diarrhoea prevention and management and also exhibited poor practices. Educational strategies aimed at improving parental knowledge and practices towards diarrhoea in their children could produce better gains in reducing the menace of poorly treated diarrhoea.
ON THE ROLE OF THE SPECIALIST IN SOLVING CRIMES
Authors: Шеметов А.К. , Васюков В.Ф.
Published: December 2021

В рамках расследования любого уголовного дела следователь вынужден прибегать к использованию специальных знаний, которыми не обладает сам. В статье рассмотрены некоторые возможности использования специальных знаний для раскрытия тяжких и особо тяжких преступлений, приводятся примеры взаимодействия следователя со специалистами различного профиля для установления личности субъекта нераскрытого посягательства.

As part of the investigation of any criminal case, the investigator is forced to resort to the use of special knowledge that he does not possess himself. The article discusses some possibilities of using special knowledge to solve serious and especially serious crimes, provides examples of the investigator’s interaction with specialists of various profiles to establish the identity of the subject of an unsolved assault.
ADMINISTRATIVE AND LEGAL RESPONSIBILITY OF ORGANIZATIONS AS A MEANS OF ANTI-CORRUPTION
Authors: Сморчкова Л.Н.
Published: December 2021

В статье исследуются особенности привлечения организаций к административной ответственности по статьям 19.28 и 19.29 КоАП РФ, а также по ряду составов административных правонарушений, косвенно указывающих на наличие в них коррупционной направленности. Рассматривается проблема расширения административной ответственности организаций и лиц в случаях совершения коррупционного правонарушения от имени или в интересах юридического лица.

The article examines the features of bringing organizations to administrative responsibility under Articles 19.28 and 19.29 of the Administrative Offenses Code of the Russian Federation, as well as for a number of administrative offenses that indirectly indicate the presence of corruption in them. The problem of expanding the administrative responsibility of organizations of persons in cases of committing a corruption offense on behalf of or in the interests of a legal entity is considered.
IMPROVING THE QUALITY OF THE EDUCATIONAL PROCESS THROUGH THE USE OF INNOVATIVE PEDAGOGICAL TECHNOLOGIES IN THE PROCESS OF PROFESSIONAL TRAINING OF TRAFFIC POLICE OFFICERS
Authors: Леонова И.А. , Савосина А.С.
Published: December 2021

В статье рассматриваются вопросы использования инновационных форм и методов преподавания в процессе профессионального обучения сотрудников ГИБДД. Определяется значимость формирования личности сотрудников полиции через внеаудиторную работу, поскольку современное общество нуждается в грамотных, высококвалифицированных специалистах, имеющих ценностно-целевые установки, суждения и определенную познавательную активность.

The article discusses the use of innovative forms and methods of teaching in the process of professional training of traffic police officers. The importance of forming the personality of police officers through extracurricular work is determined, since modern society needs competent, highly qualified specialists with value-oriented attitudes, judgments and a certain cognitive activity.
Hearing Screening and Balance Assessment in Adults with a History of Cranioencephalic Trauma
Authors: Pace Maria Clara Martins , Gil Daniela , Suriano Italo Capraro
Published: December 2021

Background: Head trauma (TBI) is a public health problem. In the present study, we highlight the post-traumatic hearing disorders consequences of TBI because of the auditory and balance complaints are reported by patients with a history of TBI. Design and setting: Cross-sectional observational study realized at Neurosurgery/Trauma at Hospital São Paulo and the UNIFESP Speech Therapy Department. Objective: Perform hearing screening and balance assessment in adult patients after TBI. Methods: individuals aged 18 to 60 years with a history of TBI of any degree for more than 06 months. Patients underwent to a medical history, they assigned two marks from 0 to 10 with the aid of a visual analog scale, the first referring to the pre-injury auditory aspects and the second from the post. Hearing screening was performed at frequencies of 1k, 2k and 4kHz with audiometer and earphones in a quiet room and the Romberg Classic and Sensitized and Time Up and Go (TUG) tests. Results: The total sample was 34, of this 35,3% failed in the right ear and 38,2% in the left. For the results of static balance, in Classic we had 5.8% with positive result and in sensitized 5.9% positive with deviation to the right, 8.8% to the left, 8.8% to the front and 2, 9% with backward deviation. In the TUG, 23,5% presented alterations. Conclusion: The performance of hearing screening and balance showed changes in patients after TBI, emphasizing the importance of these assessments in the context of the therapeutic planning of these patients.
Co-Vivências, a residence model for the elderly that integrates specialized care and family living for active longevity. “Neurology Startups”
Authors: Pelegrino Paulo Sergio , Felipe Alessandra Maria
Published: December 2021

The institutionalization of the elderly is very strongly related to the diseases and complications associated with cognitive and functional impairment present in Alzheimer’s disease, Parkinson’s disease, other dementias, and stroke sequelae. The institutionalization of elderly people represents an aid to families. On the other hand, it has been a factor related to the worsening in cognition and functionality when compared to those who remain in their social environment and family life. The different modalities of long-term care facilities (LTCFs) for the elderly in Brazil contribute a lot to the split between care and family life. The present work aims to propose a new model of real estate development, linked to the provision of specialized care without the deprivation of family life and relationship and produce greater benefits in terms of maintaining cognition, autonomy, and independence among the elderly. The future developments proposed here will consist of buildings with apartments of varying sizes according to the needs of families, adequate accessibility, differentiated circulation to facilitate access and proximity of caregivers to the elderly and to reduce the physical distance of the elderly to the assistance and coexistence spaces. They will be equipped with assistance rooms for multiprofessional service and rehabilitation, areas for food, leisure and socializing among the elderly. The Startup will bring together real estate and construction companies, developers, investors and elderly care providers, and will be responsible for the projects, their execution and monitoring. The resources for the construction come from investors, the housing will be allocated to families with elderly people and other sources will come from the provision of care and services offered to the elderly by specialized companies. In addition to the benefits for the elderly and their families, the interaction between different economic sectors and dividend production is promoted.
Effect of the bilateral Dynamic Ankle-Foot Orthosis on the spatiotemporal gait patterns of a child with chemotherapy-induced peripheral neuropathy
Authors: Barbosa Everton Horiquini , Felício Thiago
Published: December 2021

Introduction: Peripheral neuropathy induced by chemotherapy (CIPN) is a highly prevalent and clinically relevant sequel in the treatment of childhood cancer, impacting the patient’s functionality and also decreasing the quality of life, therefore, improvement in mobility and quality of walking are important goals during the rehabilitation process. The aim of this study was to compare the spatio-temporal gait patterns of a child with CIPN with or without the use of bilateral dynamic Ankle-Foot Orthosis. Methods: This is a descriptive case study consisting of an gait evaluation of a female patient with CIPN, 09 years old, 1.39m and 35kg. The spatio-temporal gait patterns, 6- minute walk test and Timed Up and Go test were obtained using a wireless inertial sensor system. Results: The obtained data in the 6MWT showed 160m of travelled distance, a speed of 0.55 m/s, a cadence of 94.9 steps/min and a stride length of 0.70m, compared to a travelled distance of 233.3m, a speed of 0.86 m/s, a cadence of 99.2 steps/min and a stride length of 104 m. The obtained data in the TUG test, showed that the participant used 24.37 seconds to complete the test without the orthosis and 18.54 seconds with the orthosis, changing to Semi-Independent to Independent classification, however, despite the improvement, the risk of falling was still considered high according to the values predicted by the software. Conclusion: Thus, the use of dynamic orthosis for patients with CIPN can be beneficial to improve speed, endurance and decrease the physiological cost of walking. Future studies comparing the effectiveness of dynamic orthosis in a larger number of patients are needed to elucidate the findings exposed in the present study.
Characterisation of nociception and inflammation observed in a traumatic muscle injury model in rats
Authors: Kudsi Sabrina Qader , Trevisan Gabriela
Published: December 2021

Introduction: Muscle pain is the most prevalent type of pain in the world, but treatment remains ineffective. Objective: Therefore, this study characterised the nociception and inflammation in a traumatic muscle injury model in rats Methods: A single blunt trauma impact on the right gastrocnemius muscle of male Wistar rats. Procedures were approved by the Institutional Committee for Animal Use of the Federal University of Santa Maria (#6579280218/2018). Animals were divided into four groups (sham/no treatment; sham/diclofenac 1%; injury/no treatment; injury/diclofenac 1%) and the topical treatment with cream of 1% monosodium diclofenac (applied at 2, 6, 12, 24, and 46 h after muscle injury; 200 mg/muscle) was used as an anti-inflammatory control. Nociception (mechanical and cold allodynia, or nociceptive score) and locomotor activity were evaluated at 26 and 48 h after injury. Also, inflammatory and oxidative parameters were evaluated in gastrocnemius muscle and the creatine kinase (CK) activity and lactate levels in plasma and serum, respectively. Results: Muscle injury caused mechanical and cold allodynia, and increased nociceptive scores, without inducing locomotor impairment. This model also increased the inflammatory cells infiltration (seen by myeloperoxidase and Nacetyl-β-D-glucosaminidase activities and histological procedure), nitric oxide, IL- 1β, IL-6, and dichlorofluorescein levels in muscle samples; and CK activity and lactate levels in serum. The treatment with 1% monosodium diclofenac reduced inflammatory cells infiltration, dichlorofluorescein, and lactate levels. Conclusion: In this view, we characterised the traumatic muscle injury as a reproducible model of muscle pain, which make it possible to evaluate promising antinociceptive and anti-inflammatory therapies.
Monoclonal antibodies: a new trend for the treatment of Alzheimer’s disease?
Authors: Requião Letícia Escorse , Freitas Giulia , Macedo Mayanna , Gondim Hanny , Antunes Blenda , Lopes Bruno
Published: December 2021

Introduction: Alzheimer’s disease (AD) is the main form of senile dementia. Most of the supposedly disease-modifying treatments in development are directed against the β-amyloid peptide, the administration of exogenous anti-Aβ monoclonal antibodies is a passive immunization strategy aimed at resolving the aggregation of this substance. Objective: Analyze the effectiveness of monoclonal antibodies in the treatment of Alzheimer’s disease. Methods: This is a literature review, based on randomized clinical trials published between 2014 and 2021. The search was conducted in the PubMed database. Results: According to the eligibility criteria, 10 articles were selected. Two of the randomized, double-blind, placebo-controlled phase III studies, one published in 2018 and the other published in 2016, evaluated the intervention with Solanezumab and Bapineuzumab, respectively. Both were not shown to be statistically significant (P = 0.10) for the outcome improvement of the score in the cognitive subscale of 14 and 11 items “Alzheimer’s Disease Assessment Scale” (ADAS-cog14 / 11). However, in a phase II randomized placebo-controlled clinical trial, published in 2021, the use of Donanemab in patients with early Alzheimer’s disease resulted in statistically significant cognitive and functional improvement (P = 0.04) for the outcome change in the scale “Integrated Alzheimer’s Disease Rating” (iADR). Conclusion: Although the use of Donanemab has resulted in cognitive and functional improvement, randomized, double-blind, placebo-controlled, phase III clinical trials need to be conducted to prove the efficacy and safety of its use in clinical practice. Other monoclonal antibodies evaluated did not demonstrate evidence of benefit.
Atypical presentation of tacrolimus encephalopathy in a kidney transplant patient
Authors: Pimenta Marina Luiza , Oliveira Jessica Andrade de , Soares Neto Herval Ribeiro , Silva Sonia Maria Cesar de Azevedo , Melo Luiza Ferrari de Castro
Published: December 2021

Context: Neurological complications triggered by tacrolimus in transplant patients can occur in a common way. Tacrolimus encephalopathy is a rare presentation. The present case follows atypical patterns of this disease, since it presented as aphasia, seizure and unusual radiological findings. Case report: A 52--year--old female patient complaining of severe headache for 3 days, associated with difficulty in formulating phrases and confusion. She had a history of nephrolithiasis, kidney transplantation (2020), hypertension and diabetes, using tacrolimus, mycophenolate and prednisone. In the hospital, she had a global aphasia and episodes of generalized tonic-- clonic seizures, being medicated with levetiracetam, phenytoin and acyclovir, maintaining good seizure control, but persisting aphasic. Brain MRI showed an extensive hypersignal in T2/FLAIR involving the left parieto-- occipito-- temporal cortical subcortical region. CSF showed: protein 91 mg/dL, glucose 143 mg/dL and leukocytes 2 cells/mm³. Negative infectious screening was performed in the CSF using FilmArray encephalitis/meningitis panel. Hypothesized an encephalopathy caused by tacrolimus we discontinued the medication and after 3 days, the patient had a significant clinical improvement, no aphasia and drastic reduction in the hypersignal extension. The patient was discharged from service using cyclosporine and prednisone. Conclusions: Tacrolimus crosses the blood--brain barrier, having a direct action on the CNS. Encephalopathy triggered by its toxicity is capable of producing several radiological patterns. After discard infectious encephalitis, it is of utmost importance to consider tacrolimus--induced encephalopathy -- due to rapid clinical and radiological remission after discontinuing the drug.
The Most Influential Papers in Infectious Meningitis Research: A Bibliometric Study
Authors: Ramos Miguel Bertelli , Farias Frederico Arriaga Criscuoli de , Teixeira Manoel Jacobsen , Figueiredo Eberval Gadelha
Published: December 2021

Background: Bibliometric analyses allow detecting citation trends within a field, including assessments of the most cited journals, countries, institutions, topics, types of study, and authors. Objectives: To perform a bibliometric analysis of the 100 most cited papers within infectious meningitis research. Methods: The 100 most cited publications and their data were retrieved from Scopus and Web of Science during 2019. Results: The New England Journal of Medicine had the greatest number of articles (27) and citations (12,266) in the top 100. Articles were mainly published after the late 1980s. Bacteria were the most discussed agents (72 articles and 26,362 citations), but Cryptococcus sp represented the most-discussed single agent (16 articles and 6,617 citations). Primary research represented 70 articles and 25,754 citations. Among them, the most discussed topic was Clinical Features and Diagnosis/Outcomes (22 articles and 8,325 citations). Among the 27 secondary research articles, the most common type of study was Narrative Review (18 articles and 5,685 citations). The United States was the country with the greatest number of articles (56) and citations (21,388). Centers for Disease Control and Prevention (CDC) and Yale University had the greatest number of articles (six each), being CDC the most cited (3,559). Conclusions: The most cited articles within meningitis research are primary research studies, more frequently published in high IF journals and by North American institutions. Bacterial meningitis comprises the majority of publications. The articles were mainly published after the AIDS pandemic and after the implementation of the main vaccines for meningitis.
Preliminary correlation between blood viscosity and pulsatility index in healthy population resident at high altitude (Cusco 3300 masl)
Authors: Saldaña Charles Huamani , Pancorbo William Bayona , Montalvo Víctor Oré , Alviz Carlos Pérez , Mamani Juan Carlos Acuña , Heredia Golda Córdova , Damián-Saavedra Paulina , Cruz-Huanca Luz , Miranda-Solis Franklin , Sarmiento-Herrera William , Antonio Dario
Published: December 2021

Background: Viscosity affects flows by increasing resistance to movement, therefore, blood viscosity (BV) could modify the pulsatility index (PI). Objectives: To determine the correlation between BV and PI. Design and setting: A cross-sectional study was conducted in clinically healthy young adults residing in Cusco (a city located at 3399 masl). Methods: A venous blood sample was taken to determine their BV levels, and a transcranial Doppler of right middle cerebral artery (R-MCA) was performed, with which the min, maximum and mean flow velocity (MFV), resistance and pulsatility indices (PI) were obtained. The BV levels were measured in centipoises (cP) using acone-plate viscometer at 40RPM. We present medians with interquartile ranges (IQR), the correlation was evaluated using the Spearman test. Results: 42 participants were included, 25 women (60%), the mean age was 26.2±5.5 years. The median of BV was 5.08cP [IQR: 4.55-5.77cP], the MFV was 56 m/s [IQR: 49- 61 m/s], and the PI was 0.94 [0.85-1.02]. BV was positively correlated with PI (r:0.38, p=0.045) and negatively with MFV (r: -0.37, p=0.011) Conclusions: The increase in blood viscosity has a small but significant impact on cerebral vascular resistance (PI) and its fluxes (MFV) in clinically healthy and young people. This could have a role in the pathogenesis of cerebral infarction in the elderly. The results presented here are preliminary and we intend to gather more data and increasing our number of participants.
Expansion of the phenotype in ALS19
Authors: Athayde Natália Merten , Pinto Wladimir Bocca Vieira de Rezende , Souza Paulo Victor Sgobbi de , Oliveira Acary Souza Bulle , Carvalho Alzira Alves de Siqueira
Published: December 2021

Context: Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease that affects the upper and lower motor neurons. Most cases are sporadic, being 5-10% familial. Currently, more than 20 genes are described as causing familial ALS, with C9ORF72 and SOD1 the most common. Case report: Woman, 42 years old, with progressive weakness in her left foot for 3 years evolving with difficulty walking. No family history. Neurological exam(NE): asymmetric stepagge gait. Asymmetric proximal, distal and axial muscle weakness and distal atrophy. Hyperactive reflexes. EMG: pre-ganglionic lesion in lower limbs with active denervation. Brain MRI: high signal intensity on left corticospinal tract. ALS genetic panel: c.3878G> A, heterozygois in ErbB4(OMIM* 600543). CASE 2: Female, 55 years old, with parkinsonism for 2 years, evolving with muscle weakness, myalgia, dysphonia and dysphagia. After 7 months, respiratory failure and death. Family history: ALS and atypical parkinsonism. NE: Global amyotrophy, facial hypomimia, dropped head, fasciculations on the tongue. Bradykinesia. Plastic hypertonia in the 4 limbs. Proximal and distal weakness. Babinski sign on the right. Oculomotor apraxia. Dysarthrophonia. EMG: pre-ganglionic lesion in the 4 limbs. Brain MRI: global cortical atrophy with temporal predominance. Exome: pathogenic variant, in heterozygosis c. 2428G>A in ErbB4. Conclusion: There are only 3 cases reported in the literature associated to pathogenic variants in this gene. We suggest an expansion of the clinical phenotype for ALS19.
Prevalence of pain and fatigue in post-stroke patients: a study transverse.
Authors: Barreto Emille de Souza Apolinario , Gondim Afonson L. M. , Araújo Raíssa S. Taveira, Denise S. , Araújo Felipe R. , Macêdo Emanuel S. , Silva Emanoelle C. V. , Pacheco Thaiana B. F. , Cacho Roberta O. , Cacho Enio W. A.
Published: December 2021

Background: Motor and functional recovery in post-stroke individuals is a process of interference from non-motor aspects such as pain and fatigue.The prevalence of these symptoms and their impact on the rehabilitation process need to bebetter understood and studied, mainly in the strategies for the construction of therapeutic approaches. Objectives: To analyze the prevalence of pain and fatigue in individual’s post-stroke. Design and setting: Cross-sectional study that followed the STROBE recommendations. An outpatient clinic at UFRN / FACISA in Santa Cruz-RN institution. Approved by the Research Ethics Committee (Opinion No. 2,622,853). Methods: One sample perconvenience, had 29 post-stroke individuals. The individuals were evaluated using the following clinical instruments: the Mini Mental State Examination (MMSE),Functional Independence (FI), Fulg-Meyer Scale (FMS), Sensory Assessment of Nottingham (SAN), McGill Pain Question (MOQ) and the Severity of Fatigue (SSF). The data were analyzed descriptively. Results: Participants presented the following characteristics clinical: MMSE, 19 (median), (0(1ºQ)/24 (3ºQ)); FI, 80 (0/121); FMS, 36 (36/88); SAN, 108 (0/108); SSF, 9 (0/27). Thus, the prevalence of pain was 28% (8) and the fatigue was present in 76% (22) of the individuals. Conclusions: We found a high prevalence of fatigue in patients with chronic stroke, however we did not find relationship with pain. Further studies are needed to understand these conditions and identify which factors contribute to the prevalence of such symptoms.
Neuroradiological markers of Vascular Cognitive Impairment after Stroke
Authors: Requião Letícia Escorse , Souza Murilo Santos de
Published: December 2021

Background: Cognitive vascular impairment (CCV) is a frequent, but overlooked, possible consequence of stroke. Neuroimaging is essential for the evaluation of these patients with cognitive deficits supposedly secondary to vascular lesions, with Nuclear Magnetic Resonance (NMR) of the skull being the most sensitive method for identifying markers associated with CCV. The most relevant markers seem to be, among others, strategic location, severity of white matter changes, as well as the degree of atrophy of the medial temporal lobe. Objective: To assess the relationship between stroke and CCV using markers from skull MRI. Methodology: This is a systematic review of observational studies published between 2005 and 2020. The search was carried out in the PubMed and SciELO databases with the keywords consulted by the following MeSH and DeCS sites: “stroke”, “MRI”, “Vascular cognitive impairment”, using the boolean operator “and”. The PRISMA check-list was used to guide this review. Results: According to the eligibility criteria, eight studies were selected. “Event location” was the marker in MRI of the skull most frequently considered, being the object of evaluation in seven of the eight studies analyzed and proving to be a statistically significant marker (p <0.05) for the prediction of CCV in six of them. 75% of the studies included in this review evaluated the relationship between the presence of “hyperintensity in the white matter” at MRI and CCV. However, this marker was shown to be statistically significant in 50% of these studies. Conclusion: A review that brought together the assessment of a wide range of possible neuroradiological predictors of CVD after stroke had not been carried out so far. It would be particularly useful to evaluate the markers in a more homogeneous way in a study with a larger sample size, which would allow quantitative analysis to measure the influence of each predictor.
Multidisciplinary Care in Huntington’s Disease: Case Report
Authors: Guerra Leonardo Cortez , Poloni Alessandra Luiza Lara , Almeida Marcela Maria Mattos
Published: December 2021

Context: Huntington’s disease (HD) is a degenerative neurological disorder with autosomal dominant inheritance resulting from the loss of GABAergic neurons in the striatum. The prevalence of HD is 10.6 to 13.7 individuals per 100,000 in the Western population. Case report: DRO is a 57- year-old female admitted to a Long-Term Care Facility in 2018 due to the diagnosis of Huntington’s Disease (HD) four years ago. The patient presented right-side hemiplegia, choreic movements in the upper extremities, postural instability, dysarthria, visual hallucinations, behavioral changes, alert and communicative. During institutionalization, the occupational therapist, physical therapist and the speech therapist performed cognitive stimulation activities, motor physiotherapy with balance training, gait and muscle strengthening, interventions for dysarthria and dysphagia prevention. After a year, there was a disease progression with episodes of fall and deterioration of choreic movements, cognitive function and coordination; then, the physical therapist intensified motor rehabilitation and bracing in the left hand in the occupational therapy sessions due to the onset of deformities. In 2020, the patient reported stabilizing her clinical condition and continued the rehabilitation sessions. Conclusions: Physiotherapeutic interventions demonstrated improvement in muscle strength and gait in HD patients. However, the results are heterogeneous due to the morbidity and phenotypic variety of the disease. The response to occupational therapy and speech therapy lacks previous studies on this disease. Thus, the multidisciplinary therapeutic approach is indicated due to its importance in the patient’s overall assessment and prevention of comorbidities.
The effects of aquatic physiotherapy on the gait of patients with Parkinson’s disease: a systematic review of the literature
Authors: Melo Yuri Sena , Miranda Wesley Anderson de Souza , Bezerra João Lucas de Morais , Teixeira Thaís Bel de Oliveira
Published: December 2021

Introduction: Parkinson’s disease is a progressive and degenerative pathology that causes several motor impairments in gait. Aquatic physiotherapy has become an alternative, as it allows the training of gait, balance and muscle relaxation in a safe environment due to the physical properties of water. Objective: to verify the main effects of aquatic physiotherapy on gait rehabilitation in patients with Parkinson’s disease. Study design: This is a systematic review. Methodology: The research was carried out in four distinct stages. Being carried out in the following databases EBSCO, Pubmed, PEDro, Science Direct and MEDLINE; obeying the following inclusion criteria: individuals diagnosed with idiopathic Parkinson’s disease; who underwent aquatic physiotherapy with or without a control group and the main outcome was the improvement in gait performance. Case studies, case series, monograph, dissertation and articles without full access were excluded. The following keywords were used in the research field (“hydrotherapy” OR “aquatic exercise OR aquatic therapy”) AND Parkinson’s disease AND Gait. Results: Ten articles with good to regular methodological quality were included. Most of the results of the study were functional mobility, balance, pathology progression and gait parameters. Conclusion: it was observed that aquatic physiotherapy promoted good results in gait performance, mainly in balance, functional mobility and decreased motor signals, however there is still evidence about gait parameters.