bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring the cortical habituation in migraine patients based on contingent negative variation
Authors: Ning Jinru , Zhang Yongxiang , Wang Yan , Liu Chang , Cheng Yingying , Zhu Mingqin , Dong Ming , Yang Xin , Lv Yudan
Published: August 2023

Introduction

Cognitive dysfunction has frequently been found in patients with migraine. The so-called contingent negative variation (CNV) and EEG power spectral densities may be the best choices to explore the underlining pathophysiology, such as cortical inhibition and habituation.

Methods

Thirty migraine patients without aura and healthy controls matched for sex, age, and education were recruited separately for CNV recording. The amplitudes, latencies, and squares of different CNV components, such as oCNV, iCNV, tCNV, and PINV, were selected and analyzed. Behavioral data, such as manual reaction time (RT), were analyzed. We used the Person correlation coefficient R to analyze different ERP components in relation to clinical characteristics. A multiple regression analysis was conducted for the migraine group. Spectral analysis of EEG data from all channels using the fast Fourier transform (FFT).

Results

The migraine group had longer A-latency, C-latency, and iCNV-latency than the control group. The migraine group had higher iCNV-amplitude, oCNV-amplitude, and tCNV-amplitude than the control group, especially those located in the occipital area. The iCNV-square, oCNV-square, tCNV-square, or PINV-square in the migraine group was significantly larger than the control group. Different correlations were found between clinical characteristics and ERP components. The delta or theta activity in the migraine group was statistically lower than in the control group.

Discussion

Our study has revealed that migraine attacks may influence responsivity, pre-activation, habituation, and cortical inhibition not only on the behavioral level but also on the electrophysiological level. Abnormal changes in cortical habituation and inhibition can be interpreted as CNV components. Additionally, analyses have revealed correlations between CNV components and various factors, including age, the clinical course of the condition, attack frequency, pain intensity, and duration. Thus, repetitive migraine attacks can lead to a reduction in cortical inhibition and subsequent impairment in executive function.
Case report: Acute necrotizing encephalopathy: a report of a favorable outcome and systematic meta-analysis of outcomes with different immunosuppressive therapies
Authors: Fischell Stefanie Zaner , Fischell Jonathan , Kliot Tamara , Tumulty Jamie , Thompson Stephen J. , Raees Madiha Q.
Published: September 2023

Acute Necrotizing Encephalopathy (ANE) is a condition characterized by symmetric, bilateral lesions affecting the thalamus and potentially other areas of the brain following an acute febrile illness. It manifests clinically as abrupt development of encephalopathy, or alteration in mental status that often includes development of seizures and progression to coma. Treatment strategies combine immunosuppressive therapies and supportive care with varying levels of recovery, however there are no universally accepted, data-driven, treatment algorithms for ANE. We first report a case of a previously healthy 10-year-old female with acute onset diplopia, visual hallucinations, lethargy, and seizures in the setting of subacute non-specific viral symptoms and found to have bilateral thalamic and brainstem lesions on MRI consistent with ANE. She was treated with a combination of immunomodulatory therapies and ultimately had a good outcome. Next, we present a meta-analysis of 10 articles with a total of 158 patients meeting clinical and radiographic criteria for ANE. Each article reported immunosuppressive treatments received, and associated morbidity or mortality outcome for each individual patient. Through our analysis, we confirm the effectiveness of high-dose, intravenous, methylprednisolone (HD-IV-MP) therapy implemented early in the disease course (initiation within 24 h of neurologic symptom onset). There was no significant difference between patients treated with and without intravenous immunoglobulin (IVIG). There was no benefit of combining IVIG with early HD-IV-MP. There is weak evidence suggesting a benefit of IL-6 inhibitor tocilizumab, especially when used in combination with early HD-IV-MP, though this analysis was limited by sample size. Finally, plasma exchange (PLEX) improved survival. We hope this meta-analysis will be useful for clinicians making treatment decisions for patients with this potentially devastating condition.
NeuroBridge: a prototype platform for discovery of the long-tail neuroimaging data
Authors: Wang Lei , Ambite José Luis , Appaji Abhishek , Bijsterbosch Janine , Dockes Jerome , Herrick Rick , Kogan Alex , Lander Howard , Marcus Daniel , Moore Stephen M. , Poline Jean-Baptiste , Rajasekar Arcot , Sahoo Satya S. , Turner Matthew D. , Wang Xiaochen , Wang Yue , Turner Jessica A.
Published: August 2023

Introduction

Open science initiatives have enabled sharing of large amounts of already collected data. However, significant gaps remain regarding how to find appropriate data, including underutilized data that exist in the long tail of science. We demonstrate the NeuroBridge prototype and its ability to search PubMed Central full-text papers for information relevant to neuroimaging data collected from schizophrenia and addiction studies.

Methods

The NeuroBridge architecture contained the following components: (1) Extensible ontology for modeling study metadata: subject population, imaging techniques, and relevant behavioral, cognitive, or clinical data. Details are described in the companion paper in this special issue; (2) A natural-language based document processor that leveraged pre-trained deep-learning models on a small-sample document corpus to establish efficient representations for each article as a collection of machine-recognized ontological terms; (3) Integrated search using ontology-driven similarity to query PubMed Central and NeuroQuery, which provides fMRI activation maps along with PubMed source articles.

Results

The NeuroBridge prototype contains a corpus of 356 papers from 2018 to 2021 describing schizophrenia and addiction neuroimaging studies, of which 186 were annotated with the NeuroBridge ontology. The search portal on the NeuroBridge website https://neurobridges.org/ provides an interactive Query Builder, where the user builds queries by selecting NeuroBridge ontology terms to preserve the ontology tree structure. For each return entry, links to the PubMed abstract as well as to the PMC full-text article, if available, are presented. For each of the returned articles, we provide a list of clinical assessments described in the Section “Methods” of the article. Articles returned from NeuroQuery based on the same search are also presented.

Conclusion

The NeuroBridge prototype combines ontology-based search with natural-language text-mining approaches to demonstrate that papers relevant to a user’s research question can be identified. The NeuroBridge prototype takes a first step toward identifying potential neuroimaging data described in full-text papers. Toward the overall goal of discovering “enough data of the right kind,” ongoing work includes validating the document processor with a larger corpus, extending the ontology to include detailed imaging data, and extracting information regarding data availability from the returned publications and incorporating XNAT-based neuroimaging databases to enhance data accessibility.
Pupil light reflex dynamics in Parkinson’s disease
Authors: Tsitsi Panagiota , Nilsson Mattias , Waldthaler Josefine , Öqvist Seimyr Gustaf , Larsson Olof , Svenningsson Per , Markaki Ioanna
Published: August 2023

Introduction

Visual disturbance is common symptom in Parkinson’s disease (PD), and defective pupil light reflex (PLR) is an anticipated contributing factor that may be associated to the presence of autonomic dysfunction, which is a common non-motor feature of PD. Studies investigating the intercorrelation between PLR and dysautonomia in PD are limited.

Methods

The aim of this study was to investigate differences of PLR parameters, measured by eye-tracker, between patients with PD, with and without signs of dysautonomia, and healthy controls (HC). In total, 43 HC and 50 patients with PD were recruited and PLR parameters were measured with Tobii Pro Spectrum, during a long (1,000 ms) and a short (100 ms) light stimulus. Presence of orthostatic hypotension (OH) was used as proxy marker of dysautonomia. Linear mixed-effects model and non-parametric comparative statistics were applied to investigate differences among groups.

Results

Peak constriction velocity was slower in PD compared with HC, after adjustment for age and sex in the mixed model, and the difference was greater in the subgroup of PD with OH (unadjusted). Dilation amplitude and velocity were also gradually slower in HC vs. PD without OH vs. PD with OH (unadjusted for confounders). In the mixed model, age was significant predictor of dilation response.

Discussion

Our results support previous observations on defective PLR in PD, evaluated with eye-tracker, and show a possible association with autonomic dysfunction. Further studies with more patients and rigorous evaluation of autonomic dysfunction are needed to validate these findings.
Cross-species evaluation of fibroblast activation protein alpha as potential imaging target for soft tissue sarcoma: a comparative immunohistochemical study in humans, dogs, and cats
Authors: Beer Patricia , Pauli Chantal , Haberecker Martina , Grest Paula , Beebe Erin , Fuchs Daniel , Markkanen Enni , Krudewig Christiane , Nolff Mirja Christine
Published: September 2023

Introduction

Complete surgical tumor resection is paramount in the management of soft tissue sarcoma (STS) in humans, dogs, and cats alike. Near-infrared targeted tracers for fluorescence-guided surgery (FGS) could facilitate intraoperative visualization of the tumor and improve resection accuracy. Target identification is complicated in STS due to the rarity and heterogeneity of the disease. This study aims to validate the expression of fibroblast activation protein alpha (FAP) in selected human, canine, and feline STS subtypes to assess the value of FAP as a target for FGS and to validate companion animals as a translational model.

Methods

Formalin-fixed and paraffin-embedded tissue samples from 53 canine STSs (perivascular wall tumor (PWT), canine fibrosarcoma (cFS), and STS not further specified (NOS)), 24 feline fibrosarcomas, and 39 human STSs (myxofibrosarcoma, undifferentiated pleomorphic sarcoma, dermatofibrosarcoma protuberans, and malignant peripheral nerve sheath tumor) as well as six canine and seven feline healthy controls and 10 inflamed tissue samples were immunohistochemically stained for their FAP expression. FAP labeling in tumor, peritumoral, healthy skin, and inflamed tissue samples was quantified using a visually assessed semiquantitative expression score and digital image analysis. Target selection criteria (TASC) scoring was subsequently performed as previously described.

Results

Eighty-five percent (85%) of human (33/39), 76% of canine (40/53), and 92% of feline (22/24) STSs showed FAP positivity in over 10% of the tumor cells. A high expression was determined in 53% canine (28/53), 67% feline (16/24), and 44% human STSs (17/39). The average FAP-labeled area of canine, feline, and human STSs was 31%, 33%, and 42%, respectively (p > 0.8990). The FAP-positive tumor area was larger in STS compared to healthy and peritumoral tissue samples (p < 0.0001). TASC scores were above 18 for all feline and human STS subtypes and canine PWTs but not for canine STS NOS and cFS.

Conclusion

This study represents the first cross-species target evaluation of FAP for STS. Our results demonstrate that FAP expression is increased in various STS subtypes compared to non-cancerous tissues across species, thereby validating dogs and cats as suitable animal models. Based on a TASC score, FAP could be considered a target for FGS.
Pediatric pulmonary infection caused by oral obligate anaerobes: Case Series
Authors: Zhijun Lai , Wenhai Yang , Peibin Zeng , Qingming Luo
Published: September 2023

Background

Pneumonia is quite common in people with chronic bedridden, severe malnutrition and underlying diseases of cerebral palsy. Although poor oral hygiene and inadequate airway protection are risk factors, case reports of childhood pneumonia caused by oral obligate anaerobes are rare.

Introduction

We reported 4 cases of oral anaerobic pneumonia and empyema diagnosed by the pediatric intensive care unit (PICU) of our hospital.

Discussion

No bacteria were detected in sputum bacterial culture, pleural water bacterial culture and blood culture of the four children. Considering that multiple sputum cultures were negative, the pleural effusion and bronchoalveolar lavage fluid were subjected to next-generation sequencing (NGS) to identify the pathogen causing pneumonia. The results found oral obligate anaerobes represented by Parvimonas micra and Porphyromonas gingivalis. After identifying the pathogenic bacteria, we changed to piperacillin tazobactam combined with metronidazole for anti-infection treatment, and the pneumonia in the above patients was improved. In addition, all four patients had different basic medical histories, and long-term bed rest, severe malnutrition, poor oral hygiene and insufficient airway protection were all high risk factors for oral anaerobic pneumonia in these children.

Conclusion

Oral obligate anaerobes are one of the pathogens to consider for pneumonia in the elderly, but they may be easily overlooked in pediatric groups. Therefore, when receiving children with high-risk factors, we should be alert to the possibility of oral obligate anaerobic bacteria infection. Educating family members to pay attention to children's oral hygiene plays an important role in preventing oral obligatory anaerobic bacteria pneumonia. NGS can be used as a rapid diagnostic method when sputum culture cannot distinguish between pathogens.
Short-term antithrombotic strategies after left atrial appendage occlusion: a systematic review and network meta-analysis
Authors: Wang Li-Man , Chen Yan , Xu Li-Li , Dai Meng-Fei , Ke Yi-Jun , Wang Bao-Yan , Zhou Lin , Zhang Ji-Fan , Wu Zhang-Qi , Zhou Yu-Jie , Gu Zhi-Chun , Xu Hang
Published: September 2023

Background: Percutaneous left atrial appendage occlusion (LAAO) has emerged as a stroke prevention strategy in patients with nonvalvular atrial fibrillation (NVAF), and these patients were required to receive antithrombotic therapy post-procedure. However, the optimal antithrombotic strategy after LAAO remains controversial. This study explored the safety and efficacy of different antithrombotic strategies after LAAO through a network comparison method.

Methods: We systematically searched the MEDLINE, Embase, and Cochrane Library databases for studies that reported the interested efficacy and safety outcomes (stroke, device-related thrombus (DRT), and major bleeding) of different antithrombotic strategies [DAPT (dual antiplatelet therapy), DOACs (direct oral anticoagulants), and VKA (vitamin k antagonist)] in patients who had experienced LAAO. Pairwise comparisons and network meta-analysis were performed for the interested outcomes. Risk ratios (RRs) with their confidence intervals (CIs) were calculated using a random-effects model. The rank of the different strategies was calculated using the surface under the cumulative ranking curve (SUCRA).

Results: Finally, 10 observational studies involving 1,674 patients were included. There was no significant difference in stroke, DRT, and major bleeding among the different antithrombotic strategies (DAPT, DOACs, and VKA). Furthermore, DAPT ranked the worst in terms of stroke (SUCRA: 19.8%), DRT (SUCRA: 3.6%), and major bleeding (SUCRA: 6.6%). VKA appeared to be superior to DOACs in terms of stroke (SUCRA: 74.9% vs. 55.3%) and DRT (SUCRA: 82.3% vs. 64.1%) while being slightly inferior to DOACs in terms of major bleeding (SUCRA: 71.0% vs. 72.4%).

Conclusion: No significant difference was found among patients receiving DAPT, DOACs, and VKA in terms of stroke, DRT, and major bleeding events after LAAO. The SUCRA indicated that DAPT was ranked the worst among all antithrombotic strategies due to the higher risk of stroke, DRT, and major bleeding events, while VKAs were ranked the preferred antithrombotic strategy. However, DOACs are worthy of consideration due to their advantage of convenience.
Antismoking agents do not contribute synergistically to semaglutide’s ability to reduce alcohol intake in rats
Authors: Aranäs Cajsa , Blid Sköldheden Sebastian , Jerlhag Elisabet
Published: August 2023

Preclinical studies have identified glucagon-like peptide-1 receptor (GLP-1R) agonists, and the antismoking agents varenicline and bupropion as tentative agents for treatment of alcohol use disorder (AUD). Combining different medications is a recent approach that has gained attention regarding heterogenous and difficult-to-treat diseases, like AUD. Successfully, this approach has been tested for the combination of varenicline and bupropion as it prevents relapse to alcohol drinking in rats. However, studies assessing the effects of the combination of semaglutide, an FDA-approved GLP-1R agonist for diabetes type II, and varenicline or bupropion to reduce alcohol intake in male and female rats remains to be conducted. Another approach to influence treatment outcome is to combine a medication with feeding interventions like high fat diet (HFD). While HFD reduces alcohol intake, the ability of the combination of HFD and semaglutide to alter alcohol drinking is unknown and thus the subject for a pilot study. Therefore, three intermittent alcohol drinking experiments were conducted to elucidate the effectiveness of these treatment combinations. We show that semaglutide, bupropion or HFD reduces alcohol intake in male as well as female rats. While various studies reveal beneficial effects of combinatorial pharmacotherapies for the treatment of AUD, we herein do not report any additive effects on alcohol intake by adding either varenicline or bupropion to semaglutide treatment. Neither does HFD exposure alter the ability of semaglutide to reduce alcohol intake. Although no additive effects by the combinatorial treatments are found, these findings collectively provide insight into possible monotherapeutical treatments for AUD.
Evaluation of the biological activities of Copaiba (Copaifera spp): a comprehensive review based on scientometric analysis
Authors: Frazão Deborah Ribeiro , Cruz Jorddy Neves , Santana de Oliveira Mozaniel , Baia-da-Silva Daiane Claydes , Nazário Rayssa Maitê Farias , Rodrigues Matheus Ferreira de Lima , Saito Miki Taketomi , Souza-Rodrigues Renata Duarte , Lima Rafael Rodrigues
Published: September 2023

Copaíba oil-resin is extracted from the trunk of the Copaíba tree and has medicinal, cosmetic, and industrial properties. As a result, widespread knowledge about the use of Copaíba oil-resin has evolved, attracting the scientific community’s attention. This paper aims to map the global knowledge production regarding the biological activities of Copaíba (Copaifera spp.). Bibliometric methodological instruments were used to conduct a search of the Web of Science-Core Collection database. The search resulted in 822 references. After screening titles and abstracts, 581 references did not meet the eligibility criteria, leaving 246 references for full-text examination. Subsequently, 15 studies were excluded, resulting in a final set of 232 records for the bibliometric analysis. In vitro was the most published study type, mainly from Brazil, from 2010 to 2020. Regarding the authors, Bastos, JK, and Ambrosio, SR were the ones with the most significant number of papers included. The most frequent keywords were Copaíba oil, Copaíba, and Copaifera. Our findings revealed global study trends about Copaíba, mainly related to its various effects and use over time. In general, all countries have conducted more research on antimicrobial and anti-inflammatory activities, also exposing its antioxidant and healing properties. Copaifera reticulata was the most investigated, followed by Copaifera langsdorffi and Copaifera multijuga in both in vitro and in vivo studies. Therefore, there is a need for human reports, given the promising results that Copaíba oils have been demonstrating.
Criteria for central respiratory chemoreceptors: experimental evidence supporting current candidate cell groups
Authors: Gonye Elizabeth C. , Bayliss Douglas A.
Published: September 2023

An interoceptive homeostatic system monitors levels of CO2/H+ and provides a proportionate drive to respiratory control networks that adjust lung ventilation to maintain physiologically appropriate levels of CO2 and rapidly regulate tissue acid-base balance. It has long been suspected that the sensory cells responsible for the major CNS contribution to this so-called respiratory CO2/H+ chemoreception are located in the brainstem—but there is still substantial debate in the field as to which specific cells subserve the sensory function. Indeed, at the present time, several cell types have been championed as potential respiratory chemoreceptors, including neurons and astrocytes. In this review, we advance a set of criteria that are necessary and sufficient for definitive acceptance of any cell type as a respiratory chemoreceptor. We examine the extant evidence supporting consideration of the different putative chemoreceptor candidate cell types in the context of these criteria and also note for each where the criteria have not yet been fulfilled. By enumerating these specific criteria we hope to provide a useful heuristic that can be employed both to evaluate the various existing respiratory chemoreceptor candidates, and also to focus effort on specific experimental tests that can satisfy the remaining requirements for definitive acceptance.
Measurement invariance of the patient health questionnaire-9 depression scale in a nationally representative population-based sample
Authors: Lee Eun-Hyun , Kang Eun Hee , Kang Hyun-Jung , Lee Hyun Young
Published: August 2023

The Patient Health Questionnaire-9 (PHQ-9) is widely used to measure the severity of depressive symptoms and to screen for depressive disorder, but its measurement invariance has received little research attention. The aim of this study was to assess the measurement invariance of the PHQ-9 across various sociodemographic and medical-condition groups. The structural validity and internal consistency of the PHQ-9 were also assessed as the prerequisite properties for measurement invariance. This study was conducted using data from the Korea National Health and Nutrition Examination Survey. The included participants comprised 5,347 people older than 19 years. Exploratory graph analysis (EGA) and confirmatory factor analysis (CFA) were performed to determine structural validity, and the omega coefficient (ω) was used to determine internal consistency. Measurement invariance (configural, metric, and scalar invariance) was evaluated using multigroup confirmatory factor analysis (MGCFA). The single structural model of the PHQ-9 that was validated by EGA was also satisfactory with fit indices of χ2 = 770.765 (p < 0.001), CFI = 0.944, SRMR = 0.040, and RMSEA = 0.076 (90% CI = 0.072–0.081). The ω of the PHQ-9 was 0.812, implying satisfactory internal consistency. The one-factor PHQ-9 had equivalent overall structure, factor loadings, and item intercepts across age groups, suggesting invariance across ages. Partial scalar invariance was demonstrated across sex and marital-status groups. Partial metric and scalar invariance were supported across education groups. Scalar invariance was supported among all of the medical-condition (hypertension, diabetes, cancer, arthritis, asthma, and heart disease) groups. Overall, the measurement invariance of the one-factor PHQ-9 was empirically supported across sociodemographic and medical-condition groups. The PHQ-9 can be reliably used to compare the severity of depressive symptoms across these groups in research and practice.
Chunking in simultaneous interpreting: the impact of task complexity and translation directionality on lexical bundles
Authors: Huang Dan Feng , Li Fang , Guo Hang
Published: August 2023

This study explored the use of phraseological frames (p-frames), a type of lexical bundle, by simultaneous interpreters as a strategy for managing cognitive loads. Specifically, using a comparable corpus of United Nations Security Council conferences, the study employed kfNgram to automatically identify the p-frames, and investigated their variations, regarding frequency, fixedness, structures, and functions among L1, L1–L2, and L2–L1 texts, which differ in cognitive loads due to task complexity and directionality of interpreting. The findings indicated that interpreters used more p-frames as cognitive loads increased; No significant difference was identified in fixedness as all texts tended to employ heavily formulaic and relatively fixed p-frames. Directionality correlated with grammatical preferences, with retour interpreting relying more on content-word-based p-frames. Additionally, task complexity correlated with functional preferences, with self-expression characterized by more stance expressions in the simple task. This study innovatively addressed the interaction of two factors that generate cognitive loads in interpreting and filled a research gap by providing empirical evidence on how directionality affects the use of formulaic language.
A new scale to assess technostress levels in an Italian banking context: the Work-Related Technostress Questionnaire
Authors: Porcari Desirée Estela , Ricciardi Emiliano , Orfei Maria Donata
Published: September 2023

Introduction

Technostress (TS) represents a multidimensional phenomenon closely related to the pervasive use of information and communication technologies. This study aimed to validate a new psychometric tool for assessing TS in an Italian banking context, the Work-Related Technostress – Questionnaire (WRT-Q). Secondly, we analyzed the role of gender and age in modulating TS manifestations.

Methods

A sample of 2,586 bank employees (51% females; age: 47.26  ±  8.6) underwent an online survey. Reliability, exploratory factor analysis (EFA), confirmatory factor analysis (CFA), ANCOVA, independent sample t-test, and correlation analyses were performed.

Results

The WRT-Q consisted of 17 items and a four-factor structure, supported by the following CFA indices: Comparative Fit Index (CFI)  =  0.985; Incremental Fit Index (IFI)  =  0.985; Goodness of Fit (GFI)  =  0.988; Root Mean Squared Error of Approximation (RMSEA)  =  0.071; and SRMR  =  0.062. A significant difference in TS levels between age classes emerged (p < 0.001) with higher levels in the over 55-year-old subgroup, while no statistically significant difference emerged for gender. Moreover, the whole sample found a significant positive association between age and TS (p < 0.001).

Discussion

The WRT-Q is a new instrument to measure TS in the workplace, it can contribute to highlighting adverse outcomes in individuals due to a dysfunctional interaction with ICT.
Building a postgraduate psychiatry training program in Liberia through cross-country collaborations: initiation stages, challenges, and opportunities
Authors: Ghebrehiwet Senait , Ogundare Temitope , Owusu Micaela , Harris Benjamin L. , Ojediran Babawale , Touma Mia , Durham Michelle P. , Hook Kimberly , Borba Christina P. C. , Henderson David C.
Published: September 2023

Background

About 80% of the nearly 2 billion people experiencing psychiatric conditions worldwide do not have access to quality, affordable mental health care. In Africa, there are 0.004 psychiatrists per 10,000 people, with the shortage exacerbated by a limited number of postgraduate psychiatry training opportunities. As of 2018, there were only two psychiatrists in Liberia.

Methods

This paper aims to offer a framework for developing postgraduate (i.e., residency) psychiatry training in resource-constrained settings to disseminate best practices and lessons learned. This article describes the approach to developing the formal global academic partnership that supported the initiation of Liberia’s first postgraduate psychiatry training program in July 2019.

Results

Authors describe strengths, challenges, and opportunities for improvement in the planning and initiation stages of the postgraduate program. Key strengths of the program planning process include: (1) collaboration with a coalition of local and national stakeholders committed to improving mental health care in Liberia; (2) early procurement of quality video conferencing equipment and internet service to facilitate remote learning and broaden access to digital materials; and (3) leveraging of intra-continental partnerships for subspecialty training. Challenges experienced include: (1) navigating the intricacies of local political and administrative processes; (2) recruiting candidates to a medical specialty with historically lower salaries; and (3) the added burden placed on the limited number of local specialists. Identified opportunities include building a monitoring, evaluation, and learning (MEL) framework, further diversifying subspecialty areas of psychiatric and neurological training, and obtaining full accreditation of the postgraduate psychiatry program through the West African College of Physicians (WACP).

Conclusion

The successful launch of the postgraduate psychiatry training program in Liberia is attributed to several factors, including a long-standing academic collaboration of over 10 years and support for mental health capacity-building efforts at national and local levels.
Impact of forestry on environment and human health: an evidence-based investigation
Authors: Addas Abdullah
Published: September 2023

There is an increasing interest in the health effects of the forest. Without active participation in forestry, conflicts between the various stakeholders are foreseeable. The impact of forests on human life is unforgettable, and everyone gets enormous benefits from trees and greenery. COVID-19 has caused many changes in human behavior, which needs much attention. Environmental change's impact is considered a better solution and influences human behavior. Scientists around the globe are conducting research experiments on trees and the effect of forestry on human health, which is increasing in terms of social, ecological, and economic services. Trees provide full support to enhance the quality of life and minimize air pollution. Forests must be noticed to get benefits (e.g., carbon storage, fruits, human health considerations, economic benefits, and biodiversity). This research aims to explain the area of forest and health from the perspective of Saudi Arabian forestry and develop strategic measures for the proactive design of this topic. The research entailed expert interviews with forestry representatives and a quantitative survey of medical students. Our findings show that implementing strategic measures, such as establishing a forest and health, improves health and eliminates air pollution. It shows many other establishment and planning strategies, such as the use of professional visitor monitoring, the development of product innovations, the use of digitalization, and the development of integrated forest management.
Application note: TDbasedUFE and TDbasedUFEadv: bioconductor packages to perform tensor decomposition based unsupervised feature extraction
Authors: Taguchi Y-h. , Turki Turki
Published: September 2023

Motivation

Tensor decomposition (TD)-based unsupervised feature extraction (FE) has proven effective for a wide range of bioinformatics applications ranging from biomarker identification to the identification of disease-causing genes and drug repositioning. However, TD-based unsupervised FE failed to gain widespread acceptance due to the lack of user-friendly tools for non-experts.

Results

We developed two bioconductor packages—TDbasedUFE and TDbasedUFEadv—that enable researchers unfamiliar with TD to utilize TD-based unsupervised FE. The packages facilitate the identification of differentially expressed genes and multiomics analysis. TDbasedUFE was found to outperform two state-of-the-art methods, such as DESeq2 and DIABLO.

Availability and implementation

TDbasedUFE and TDbasedUFEadv are freely available as R/Bioconductor packages, which can be accessed at https://bioconductor.org/packages/TDbasedUFE and https://bioconductor.org/packages/TDbasedUFEadv, respectively.
The reaction rate of radiative n8Li capture in the range from 0.01 to 10 T9
Authors: Dubovichenko S. B. , Yeleusheva B. M. , Burkova N. A. , Tkachenko A. S.
Published: September 2023

Within the modified potential cluster model (MPCM) with forbidden states, the total cross sections are calculated for capture in the ground and first excited states of the9Li nucleus in then8Li channel in the energy range from 10−5 eV to 5 MeV based onЕ1 andM1 transitions. The experimentally proved resonance atEc.m.= 0.232 MeV in the4P5/2wave andab initio-predicted4P3/2resonance at 1.32 MeV [Phys. Rev. C 103, 035801 (2021)] are considered. The strong impact of the asymptotic constant and channel spectroscopic factors on the total capture cross sections are responsible for the variation in the absolute values within factor two. As a consequence, the thermal cross sections areσtherm=24–46.8 mb. The evaluation ofσthermbased on the extrapolation ofab initiocross sections yields ∼85 mb. The reaction rate is calculated in the temperature range from 0.01 to 10T9. The reported reaction rates are compared at the benchmark point 1T9. The comparison of two datasets [Phys. Rev. C 103, 035801 (2021) and Phys. Rev. C 105, 064608 (2022)] on reaction rates recently calculated in microscopic models in extended temperature intervals shows the essential quantitative and qualitative differences. The comparative joint analysis of the reaction rates of radiative neutron capture on the lithium isotopes6,7,8Li is suggested for the choice of an optimal interval for the asymptotic constants.
The income and food security impacts of soil and water conservation technologies in Tanzania
Authors: Manda Julius , Tufa Adane Hirpa , Alene Arega , Swai Elirehema , Muthoni Francis , Hoeschle-Zeledon Irmgard , Bekunda Mateete
Published: September 2023

Soil and water conservation technologies are critical in reducing drought and soil erosion risks and increasing crop yields and incomes. Yet, there is limited empirical evidence on the extent and impacts of adopting soil and water conservation technologies in Tanzania. The study’s objective is to evaluate the adoption (as well as the duration of adoption) and the impacts of soil and water conservation technologies on income and food security in Tanzania. The study employs a control function approach and the instrumental variable quantile treatment effects model to survey data from 575 households to estimate the average and distributional impacts of adoption. The results show that the adoption and duration of adopting soil and water conservation technologies had significant and positive effects on the total value of crop production and household income. Moreover, we find that the adoption and its duration had a significant and positive impact on the food security indicator—household dietary diversity. The results from the instrumental variable quantile treatment effects model also show that the impacts of adopting soil and water conservation technologies on the outcome variables are positive and significant, although they vary significantly across the income and food security distributions. The results indicate that even though adoption benefits households in both the lower and upper quantiles of the income and food security distributions, the marginal impacts of adoption are generally more significant for the households in the upper quantiles. The paper concludes by discussing the policy options for increasing and sustaining the adoption and impacts of soil and water conservation technologies in Tanzania.
Inhibitory effect of vanillin on Pseudomonas syringae pv. actinidiae of kiwifruit surface and its effect on the quality of fruits
Authors: Lin Wenli , Li Wen , Huang Tianyu , Yin Chunfeng , Liu Fang , Gong Biya , He Kejia , Xiao Fulian , Yang Shuizhi , Bu Fanwen , Tang Fang , Cao Jinhua
Published: September 2023

The bacterial pathogen Pseudomonas syringae pv. actinidiae (Psa) adheres to the surface of kiwifruit and can spread over long distances during fruit transport and sales. It is crucial to investigate efficient approaches to eliminate Psa from the surface of kiwifruit, ensuring the prevention of Psa dissemination and maintaining the overall quality of kiwifruit. Vanillin is used for the preservation of agricultural products due to its antiseptic and bactericidal effect. In this paper, Psa was used to infect Cuiyu kiwifruits, and inhibition of exogenous vanillin on Psa and effects on the quality of the treated kiwifruits were investigated. According to the results of the inhibition of Psa through exposure to vanillin, the effectiveness of inhibition on the surface of kiwifruit was as follows: 61.29, 92.33, 96.79, and 100% for the concentrations of vanillin at 5.0 mg·mL−1, 6.0 mg·mL−1, 7.0 mg·mL−1, 8.0 mg·mL−1, 9.0 mg·mL−1, and 10.0 mg·mL−1, respectively. According to the quality results, kiwifruits treated with 8.0 mg·mL−1 vanillin exhibited a significant reduction in weight loss and rotting rate, with a decrease of 23.09 and 28.39% respectively, as compared to the control group. Additionally, thesetreated samples maintained a high level of total soluble solids, exhibited delayed degradation of total sugar content during a later period, inhibited an increase in respiratory intensity, and demonstrated increased firmness. Furthermore, vanillin treatment significantly increased the active values of superoxide, catalase, and peroxidase dismutase by 16.37, 28.75, and 23.92% respectively, compared to the control group. However, the levels of vitamin C and titratable acidity were not significantly affected by vanillin treatment. In conclusion, exogenous vanillin treatment exhibited potent inhibition capabilities against Psa, and effectively maintained the quality of kiwifruits during their shelf life. This study could provide reference basis for controlling the propagation of Psa and developing a new and natural kiwifruit preservative.
Flexible ureteroscopic lithotripsy with a suctioning ureteral access sheath for removing upper urinary calculi under local anesthesia
Authors: Zhang Zhaolin , Leng Song , Xie Tianpeng , Yuan Yuanhu , Wang Xiaoning
Published: August 2023

Objectives

We aimed to probe the safety and effectiveness of flexible ureteroscopic lithotripsy (FURL) with a suctioning ureteral access sheath (S-UAS) for removing upper urinary calculi under local anesthesia (LA).

Materials and methods

The clinical data of 56 patients with upper urinary calculi treated by FURL with an S-UAS under LA during the period between September 2019 and November 2022 were analyzed retrospectively. For LA, intramuscular pethidine (1.0–2.0 mg/kg) and phenergan (25 mg) were administered 30 min prior to surgery, and oxybuprocaine hydrochloride gel was administered through the urethra at the start of the surgery. The S-UAS and flexible ureteroscope were used for FURL. Demographic characteristics, stone-related parameters, and clinical outcomes were analyzed.

Result

A total of 66 procedures were performed successfully on 46 patients (Group A), who underwent unilateral surgeries, and on 10 patients (Group B) who underwent same-session bilateral surgeries. All 56 patients were operated upon without altering the anesthesia strategy, and none required additional analgesia. The mean stone sizes of the Group A and Group B patients were 20.24 ± 5.45 mm and 29.40 ± 3.89 mm, respectively. The mean operative times of the two groups were 53.04 ± 13.35 min and 90.00 ± 15.81 min, respectively. In Group A, the stone-free rates (SFRs) were 76.1% (35/46) and 85.1% (40/46) at postoperative day 1 and day 30, respectively. In Group B, the SFRs were 80.0% (16/20) and 85.0% (17/20), respectively. Four (8.7%) patients in Group A suffered complications such as fever, stent pain, urosepsis, and steinstrasse. In Group B, one (10%) patient suffered from fever.

Conclusion

FURL, combined with an S-UAS under LA, is a feasible option and provides satisfactory clinical outcomes for appropriately selected patients.
Comparative analysis of PB2 residue 627E/K/V in H5 subtypes of avian influenza viruses isolated from birds and mammals
Authors: Briggs Kelsey , Kapczynski Darrell R.
Published: September 2023

Avian influenza viruses (AIVs) are naturally found in wild birds, primarily in migratory waterfowl. Although species barriers exist, many AIVs have demonstrated the ability to jump from bird species to mammalian species. A key contributor to this jump is the adaption of the viral RNA polymerase complex to a new host for efficient replication of its RNA genome. The AIV PB2 gene appears to be essential in this conversion, as key residues have been discovered at amino acid position 627 that interact with the host cellular protein, acidic nuclear phosphoprotein 32 family member A (ANP32A). In particular, the conversion of glutamic acid (E) to lysine (K) is frequently observed at this position following isolation in mammals. The focus of this report was to compare the distribution of PB2 627 residues from different lineages and origins of H5 AIV, determine the prevalence between historical and contemporary sequences, and investigate the ratio of amino acids in avian vs. mammalian AIV sequences. Results demonstrate a low prevalence of E627K in H5 non-Goose/Guangdong/1996-lineage (Gs/GD) AIV samples, with a low number of mammalian sequences in general. In contrast, the H5-Gs/GD lineage sequences had an increased prevalence of the E627K mutation and contained more mammalian sequences. An approximate 40% conversion of E to K was observed in human sequences of H5 AIV, suggesting a non-exclusive requirement. Taken together, these results expand our understanding of the distribution of these residues within different subtypes of AIV and aid in our knowledge of PB2 mutations in different species.
Lightweight Design for Active Small SAR S-STEP Satellite Using Multilayered High-Damping Carbon Fiber-Reinforced Plastic Patch
Authors: Koo Kyung-Rae , Kim Hyun-Guk , Kim Dong-Geon , Kwon Seong-Cheol , Oh Hyun-Ung
Published: September 2023

In the launch environment, satellites are subjected to severe dynamic loads. These dynamic loads in the launch environment can lead to the malfunction of the payload, or to mission failure. In order to improve the structural stability of satellites and enable the reliable execution of space missions, it is necessary to have a reinforcement structure that reduces structural vibrations. However, for active small SAR satellites, the mass requirements are very strict, and this makes it difficult to apply an additional structure for vibration reduction. Therefore, we have developed a carbon fiber-reinforced plastic (CFRP)-based laminated patch to obtain a vibration reduction structure with a lightweight design for improving the structural stability of an S-STEP satellite. To verify the vibration reduction performance of the CFRP-based patch, sine and random vibration tests were conducted at the specimen level. Finally, the structural stability of the S-STEP satellite with the proposed CFRP-based laminated patch was experimentally verified using sine and random vibration tests. The validation results indicate that the CFRP-based laminated patch is an efficient solution which can effectively reduce the vibration response without the need for major changes to the design of the satellite structure. The lightweight vibration reduction mechanism developed in this study is one of the best solutions for protecting vibration-sensitive components.
Energy Analysis for Solar-Powered Unmanned Aerial Vehicle under Static Soaring
Authors: Wu Yansen , Li Ke , Zhao Anmin , Liu Haobo , Li Yuangan , Wen Dongsheng
Published: September 2023

Endurance is a critical factor for solar-powered unmanned aerial vehicles (SUAVs). Taking inspiration from birds, SUAVs have the ability to harvest extra energy from atmospheric thermal updrafts to extend their endurance. Though recent research has mainly focused on estimating the characteristics of thermal updrafts, there is a noticeable dearth of studies investigating the energy performance of SUAVs during soaring under different conditions. To begin with, this work establishes a thermal updraft and SUAV energy model. In addition, it introduces an integrated guidance and control process to achieve static soaring within thermal for SUAVs. Numerical simulations are implemented to analyze the electric energy performance at different solar irradiation levels, SUAV velocities and thermal strengths. Several remarkable conclusions are drawn from the simulations, which could provide significant insights for SUAVs to further exploit thermal energy.
Prediction of Tea Varieties’ “Suitable for People” Relationship: Based on the InteractE-SE+GCN Model
Authors: Huang Qiang , Wu Zongyuan , Wang Mantao , Tao Youzhi , He Yinghao , Marinello Francesco
Published: September 2023

This study proposes an improved link prediction model for predicting the “suitable for people” relationship within the knowledge graph of tea. The relationships between various types of tea and suitable target groups have yet to be fully explored, and the existing InteractE model still does not adequately capture a portion of the complex information around the interactions between entities and relationships. In this study, we integrate SENet into the feature layer of the InteractE model to enhance the capturing of helpful information in the feature channels. Additionally, the GCN layer is employed as the encoder, and the SENet-integrated InteractE model is used as the decoder to further capture the neighbour node information in the knowledge graph. Furthermore, our proposed improved model demonstrates significant improvements compared to several standard models, including the original model from public datasets (WN18RR, Kinship). Finally, we construct a tea dataset comprising 6698 records, including 330 types of tea and 29 relationship types. We predict the “suitable for people” relationship in the tea dataset through transfer learning. When comparing our model with the original model, we observed an improvement of 1.4% in H@10 for the WN18RR dataset, a 7.6% improvement in H@1 for the Kinship dataset, and a 5.2% improvement in MRR. Regarding the tea dataset, we achieved a 4.1% increase in H@3 and a 2.5% increase in H@10. This study will help to fully exploit the value potential of tea varieties and provide a reference for studies assessing healthy tea drinking.