bluuebunny/crossref_metadata_2025 huggingface dataset:
Perú, sabor y saber: bases y técnicas de la cocina peruana
Authors:   Universidad San Ignacio de Loyola, De La Fuente Diez Canseco Luciana
Published: March 2021

En los últimos 15 años se ha producido un boom gastronómico en el Perú. Su cocina no es solo ya el principal motivo de identidad cultural y orgullo de los peruanos, sino que en poco tiempo ha entrado en las esferas privilegiadas de la gastronomía internacional. Sus restaurantes figuran como los mejores de América Latina y líderes en el mundo. Perú ha sido considerado en los World Travel Awards –por cinco años consecutivos– como el mejor destino gastronómico del planeta. Y The World’s 50 Best Restaurants del 2015 premió a tres restaurantes nacionales, y en su edición regional fueron nueve los reconocidos, entre ellos, el primer lugar.
Dampak Inflasi dan Dana Pihak Ketiga terhadap Pembiayaan dengan Moderasi Pertumbuhan Ekonomi
Authors: Pratami Arifa
Published: March 2021

Abstrak- Penelitian ini bertujuan untuk menganalisis dampak inflasi dan Dana Pihak Ketiga terhadap pembiayaan dengan menjadikan pertumbuhan ekonomi sebagai variabel moderating. Penelitian ini menggunakan data sekunder berbentuk bulanan dari periode Januari 2010 sampai dengan Desember 2017 dengan objek perbankan syariah. Teknik analisis data yang digunakan yaitu analisis Error Correction Model (ECM). Hasil penelitian menemukan bahwa pertama, Inflasi tidak memiliki pengaruh yang signifikan terhadap pembiayaan pada perbankan syariah baik secara langsung maupun dengan adanya variabel moderasi pertumbuhan ekonomi. Kedua, Dana Pihak Ketiga (DPK) tidak memiliki pengaruh signifikan secara langsung terhadap pembiayaan, sedangkan dengan adanya variabel moderasi pertumbuhan ekonomi, ditemukan bahwa pertumbuhan ekonomi mampu memoderasi pengaruh yang diberikan Dana Pihak Ketiga (DPK) terhadap pembiayaan dengan arah yang negatif. Rekomendasi yang dapat diberikan yaitu diharapkan perbankan syariah tetap meningkatkan penyaluran Dana Pihak Ketiga (DPK) di sektor rill disamping tetap memanfaatkan instrument pembiayaan investasi jangka pendek berupa Sertifikat Bank Indonesia Syariah (SBIS), guna meningkatkan tingkat profitabilitas perbankan.
Kata kunci: Perbankan Syariah, inflasi, Dana Pihak Ketiga, Pertumbuhan Ekonomi.
Dampak dari Pembangunan Jalan Lintas Selatan (JLS) terhadap Kawasan Pesisir Pantai di Kabupaten Malang Selatan
Authors: Cahyo Herman Cahyo Diartho
Published: March 2021

Abstrak - Kesenjangan wilayah terjadi karena setiap wilayah dengan wilayah lain memiliki perbedaan faktor endowment. Faktor itu berbentuk seperti : sumberdaya manusia, wilayah geografis, serta ketersediaan sarana dan prasarana pembangunan. Hal ini diperkuat oleh pendapat ekonom mazhab neoklasik, antara lain : Walter Isard (1950,63), Myrdal (1976, 56-59 dan 62-65), Friedmann  (1979, 221) dan yang terakhir adalah Douglass (1979, 76). Hasil penelitian menjelaskan bahwa infrastruktur Jalan Lintas Selatan di Wilayah Kabupaten Malang Selatan memberikan eksternalitas positif pada pembangunan ekonomi lokal masyarakat kawasan pesisir pantai. Selain itu juga meningkatkan kapitalisasi pada sektor input pada industri perikanan pantai dengan meningkatkan investasi dan penambahan armada kapal. Eskternalitas negatif terjadi tarikan sumberdaya alam di kawasan pesisir pantai ke seluruh pusat-pusat ekonomi di Malang Raya secara cepat dan masif. Ketersediaan sumber daya alam pesisir pantai masih dalam kategori lestari meskipun dilakukan eksplorasi yang cenderung meningkat setelah pembangunan infrastruktur Jalan Lintas Selatan (JLS).  Metode alat analisis yang digunakan adalah Maksimum Sustainable Yiel/MSY dan Valuasi Ekonomi (Contingen Valuasi Methode/CVM) untuk menelaah hasil formulasi nilai Willingness to Pay/WTP dan nilai Willingness to Act/WTA. Tarikan sumber daya kawasan pesisir pantai di jelaskan secara dskriptif kualitatif. Paradigma Pembangunan Keberlanjutan  digunakan dalam menjelaskan ekternalitas infrastruktur Jalan Lintas Selatan (JLS) terhadap pengembangan wilayah kawasan pesisir pantai di Kabupaten Malang Selatan.
Kata Kunci:  Wilayah Pesisir Pantai, Sumberdaya Alam dan Pembangunan Keberlanjutan
Kontribusi Sektor Pertanian Subsektor Tanaman Pangan terhadap PDRB pada Kabupaten Banjar (Pendekatan PDRB Hijau)
Authors: Utari Erika Anindya Tyas , Zulfaridatulyaqin Siti Mutmainah
Published: March 2021

Abstraksi – Penelitian ini bertujuan untuk mengetahui dan menganalisis nilai deplesi, degradasi, kontribusi hijau, serta kontribusi riil sektor pertanian subsektor tanaman pangan di Kabupaten Banjar.  Data diolah dengan perhitungan matematis menggunakan pendekatan PDRB hijau. Penelitian ini merupakan penelitian deskriftif kuantitatif dengan jenis data yang digunakan yaitu data sekunder berupa time series antara tahun 2015-2018 dan didukung pula data primer melalui wawancara secara tidak terstruktur. Hasil penelitian menunjukkan nilai deplesi dan degradasi yang relatif besar, sebesar Rp 378 milyar pada tahun 2015, meningkat Rp 460,6 milyar pada tahun 2016, menurun menjadi Rp 403,1 milyar pada tahun 2017, dan menurun lagi menjadi sebesar Rp 364,8 milyar pada tahun 2018. Nilai yang besar tersebut merupakan nilai lingkungan yang hilang akibat kegiatan pertanian. Kontribusi riil sektor pertanian subsektor tanaman pangan di Kabupaten Banjar setelah diperhitungkan nilai deplesi dan degradasi terhadap PDRB meningkat rata-rata sebesar 47,81% dalam tahun 2015-2018. Kontribusi riil sektor pertanian sub sektor tanaman pangan di Kabupaten Banjar menunjukkan angka yang besar karena sudah dimasukkan perhitungan unsur lingkungan aset modal alami. Nilai kontribusi riil yang tinggi ini dapat menjadi cara meningkatkan pendapatan daerah dengan implikasi pelestarian lingkungan yang berkelanjutan.
 Kata Kunci: PDRB Hijau, Sektor Pertanian, Subsektor Tanaman Pangan, Deplesi, Degradasi.
KERJASAMA SEKOLAH DAN ORANGTUA DALAM PROSES PENDIDIKAN TAHFIDZ AL-QUR’AN PADA ANAK DI SEKOLAH TAHFIDZ PLUS SD KHOIRU UMMAH BANJARMASIN
Authors: Apriati Yuli
Published: March 2021

Penelitian ini secara umum bertujuan untuk mendekripsikan program sekolah yang melibatkan orang tua siswa dalam proses pendidikan anak di Sekolah Dasar Tahfidz Plus Khoiru Ummah Banjarmasin. Dua tujuan dalam penelitian ini yaitu upaya pelibatan orangtua dalam pendidikan anak di Sekolah Dasar Tahfidz Plus Khoiru Ummah Banjarmasin, dan bentuk kerjasama sekolah dan orangtua dalam proses pendidikan anak di Sekolah Dasar Tahfidz Plus Khoiru Ummah Banjarmasin.  Hasil penelitian menunjukkan upaya pelibatan orangtua dalam pendidikan anak di Sekolah Dasar Tahfidz Plus Khoiru Ummah Banjarmasin yaitu menjalin kerjasama dengan orangtua siswa dengan menciptakan iklim sekolah yang nyaman, merencanakan keterlibatan orangtua dan menyiapkan pola kegiatan harian siswa dirumah sebagai langkah mudah untuk melakukan kontak dengan orangtua. Proaktif melakukan pendekatan ke orangtua, dengan melihat kekuatan dari sebuah keluarga, dan merencanakan keterlibatan orangtua dalam setiap kegiatannya. Bentuk kerjasama sekolah dan orangtua dalam proses pendidikan anak di Sekolah Dasar Tahfidz Plus Khoiru Ummah Banjarmasin berupa parenting di awal masuk sekolah dan parenting acara tahunan, komunikasi, baik komunikasi formal dan informal, serta komunikasi langsung dan tidak langsung, serta keterlibatan orangtua pada pembelajaran anak di rumah, khususnya pendampingan kegiatan anak pada sabtu dan minggu.
PERUBAHAN KEHIDUPAN GOTONG ROYONG MASYARAKAT PEDESAAN DI KECAMATAN PADAHERANG KABUPATEN PANGANDARAN
Authors: Widaty Cucu
Published: March 2021

Penelitian ini memaparkan mengenai kehidupan gotong royong pada masyarakat pedesaan di Kecamatan Padaherang Kabupaten Pangandaran yang mengalami perubahan sebagai akibat pergeseran nilai-nilai budaya. Tujuan dari dilakukannya penelitian ini untuk mendeskripsikan perubahan kehidupan gotong royong masyarakat pedesaan di Kecamatan Padaherang Kabupaten Pangandaran. Metode penelitian yang digunakan dalam penelitian ini yaitu metode etnografi dengan pendekatan kualitatif. Menggunakan observasi dan wawancara sebagai alat pengumpul data yang dilakukan peneliti terhadap informan penelitian. Selain dari itu juga diperoleh data perubahan gotong royong pada masyarakat melalui dokumentasi dari pemerintah setempat. Subjek penelitian dalam penelitian ini adalah masyarakat, tokoh masyarakat, dan pemerintah desa yang dianggap cukup mendukung untuk fokus penelitian. Untuk menjawab rumusan masalah yang telah ditetapkan oleh peneliti adalah menggunakan pedoman wawancara yang sudah dirancang sedemikian rupa berdasarkan kisi-kisi instrumen penelitian, selain itu juga didukung oleh hasil observasi yang sudah dilakukan oleh peneliti selama 2 bulan. Untuk menguji keabsahan data dilakukan wawancara beberapa kali kepada informan untuk memastikan bahwa jawaban informan sudah pasti. Melalui memberchek, triangulasi, dan comprehensive data treatment hingga diperoleh kesimpulan yang kokoh. Hasil penelitian dapat diketahui bahwa perubahan kehidupan gotong royong masyarakat pedesaan ini ditandai dengan sikap dan perilaku masyarakat itu sendiri yang mulai merasa bosan dengan kegiatan-kegiatan berlandaskan gotong royong baik aktivitas yang bersifat rutin maupun insidental. Masyarakat kini lebih memilih untuk mengefisienkan waktu dan tenaga. Selain itu desakan ekonomi juga merupakan salah satu hal yang paling dominan dalam penyebab perubahan kehidupan gotong royong masyarakat di pedesaan. Hal ini berdampak pada berubahnya sikap dan perilaku masyarakat itu sendiri serta lingkungannya. Oleh karena itu pemerintah serta masyarakat bersama-sama berupaya untuk mengembalikan kehidupan gotong royong seperti semula.
KISAH LIMA PETANI DESA SUNGAI KALI (Studi Tentang Pandangan Hidup Orang Desa Sungai Kali Kecamatan Barambai Kabupaten Batola)
Authors: Ruswinarsih Sigit
Published: March 2021

Tulisan ini menguraikan tentang pandangan hidup yang diyakini oleh orang desa sebagai pedoman kehidupannya. Secara teoritis temuan tentang pandangan hidup orang desa ini dapat menambah khasanah keilmuan baik secara sosiologis maupun antropologis. Dalam keilmuan pendidikan, ikhwal pandangna hidup dapat menjadi pembelajaran tentang nilai-nilai kehidupan yang membentuk karakter anak bangsa. Dipandang dari segi praktis, hasil studi tentang pandangan hidup dapat menjadi sumber inspirasi kehidupan bagi masyarakat.. Bagi petani Desa Sungai Kali, prinsip dalam hidup berkeluarga meliputi: prinsip pandai-pandai bersyukur dan bersabar, keluarga harus menyatu sampai kapanpun, tidak boleh ada rahasia antar suami istri dan ajarkan tentang halal dan haram, berkeluarga sampai tuntung pandang (langgeng) dan terakhir bahwa dalam keluarga harus mengutamakan kerukunan. Prinsip dalam bekerja teridentifikasi bahwa dalam bekerja mencari nafkah harus diupayakan sendiri secara mandiri, bekerja harus tuntas sampai selesai tidak boleh setengah–setengah, pekerjaan yang dilakukan harus memperhatikan ke-halalan-nya, prinsip selanjutnya, sukses diraih dengan bekerja keras. Pegangan dalam berkehidupan bermasyarakat meliputi, perilaku yang baik, berbaik hati dengan sesama, tidak membicarakan orang lain di belakangnya, tidak bertengkar dengan tetangga, berbagi pengalaman dengan sesama.
Solidaritas Sosial Kelompok Waria Paris Barantai Di Banjarmasin
Authors: Ruswinarsih Sigit
Published: March 2021

Kelompok waria masih menjadi sorotan yang menarik untuk diteliti. Tulisan ini menguraikan tentang kelompok waria sebagai kelompok marginal, yang sulit untuk bertahan di tengah masyarakat dengan kesulitan dan tekanan yang mereka hadapi. Para waria tergabung dalam komunitas waria di kota Banjarmasin, berbeda dengan komunitas lain pada umumnya. Penelitian ini bertujuan untuk mengetahui tindakan waria bergabung dalam  komunitas  waria  Paris  Barantai  Banjarmasin dan bentuk solidaritasnya. Hasil penelitian menunjukkan bahwa tindakan bergabung waria dalam komunitas Paris Barantai adalah tindakan rasionalitas instrumental, tindakan  dilakukan dipertimbangkan dengan sadar untuk mencapai tujuan. Tujuan untuk menjadi waria yang baik dan dapat merubah citra waria. Waria memiliki motivasi dalam bertindak untuk memenuhi kebutuhan yang belum terpenuhi, yaitu rasa aman, cinta kasih, memiliki dan dimiliki,  penghargaan,  aktualisasi  diri  dan  indentitas  diri.  Menjadi  bagian  komunitas waria mendapatkan manfaat yaitu mengembangkan diri, mendapat pengetahuan,merubah citra waria, menjadi waria berkualitas, mendapat lapangan pekerjaan, dan mendapatkan keluarga baru. Bentuk solidaritas komunitas waria yaitu solidaritas mekanik. Bentuk solidaritas mekanik dikomunitas ini karena  kesadaran kolektif dan kesamaan. Kesamaan untuk menjadi waria yang lebih baik dan merubah citra waria, menginginkan kehidupan yang lebih baik dan normal, sama minat untuk mengekspresikan diri sebagai wanita, dan memiliki keadaan yang sulit, dan nasib yang tidak bebas untuk melakukan segala hal. Waria selalu memelihara solidaritas dengan kegiatan rutin dan tidak rutin yang mereka lakukan.
Solidaritas Sosial Dalam Tradisi Nganyuh Mu’au Dikalangan Petani Padi Masyarakat Dayak Ma’anyan Di Desa Matarah Kecamatan Dusun Timur Kabupaten Barito Timur
Authors: , Yusuf Hidayat, Laila Azkiah Nita Apriani
Published: March 2021

Ditengah pesatnya perkembangan zaman seperti sekarang ini suku Dayak masih memiliki nilai-nilai dasar yang diwarisi dari kehidupan leluhurnyang tampak pada bagaimana mereka memenuhi kebutuhan pokok. Hal tersebut dapat terlihat dari kehidupannmasyarakat Dayak Ma’anyan di Desa Matarah yang memiliki kearifan lokal dalam mengelola alam dan lingkungannya. Hasil penelitian menunjukan bahwa: (1) Mekanisme tradisi nganyuh mu’au meliputi tiga tahap yaitu pertama, tahap persiapan, tahap ini dilakukan oleh pemilik lahan dengan menyiapkan benih padi dan alat yang digunakan, melakukan upacara muras wini, melakukan pembakaran tongkat serta doa bersama. kedua, tahap pelaksanaan, pada tahapnpelaksanaan tradisi nganyuh mu’au setiap anggota memasuki lahan dengan mengikuti arahan pemilik lahan. Tadisi nganyuh mu’au dilakukan oleh pria maupun wanita, dimana pria berjalan didepan untuk membuat lobang ditanah, dan wanita mengiringi dibelakang untuk menabur benih padi pada lobang tersebut. Ketiga. tahap penutup, pada tahap ini kegiatan tradisi nganyuh mu’au ditutup dengan istirahat dan makannbersama. (2) Solidaritas mekanik merupakan bentuk solidaritas dalam tradisi nganyuh mu’au pada petani padi masyarakat Dayak Ma’anyan di Desa Matarah, hal tersebut dilihat darinrendahnya pembagian kerja, tingginya kesadaran kolektif masyarakat, dan hukum yang di terapkannbersifat represif.
Justice, equality and liberty: Inspiration from the Indian Constitution for effective diabetes management
Authors: KALRA SANJAY , VERMA MADHUR
Published: March 2021

Diabetes Mellitus (DM) could have easily been labelled as the “black swan” of the 21st century, had Covid­19 not emerged as a pandemic. Modern diabetes care in India grapples with multiple challenges. The twin enemies of uncontrolled hyperglycaemia and unwanted hypoglycaemia pose an ethical dilemma during the decision­making process of DM management. With an unfavourable support system against this rapidly emerging public health threat, we look to the Indian Constitution for guidance. Apart from just euglycaemia (a state of normal blood glucose levels), every Indian living with DM has some requirements and rights, that can be summarised with the help of three basic principles of the Constitution, ie, justice, equality and liberty. Together, these words remind us to practise accurate and appropriate diabetes care, delivered in a patient­centred manner. Justice, equality and liberty should be incorporated into diabetes­care systems, and fraternity encouraged. This will ensure that we achieve the dreams of our founding fathers through evolution of a comprehensive disease management model.
A qualitative inquiry into stigma among patients with Covid-19 in Chennai, India
Authors: Gopichandran Vijayaprasad , Subramaniam Sudharshini
Published: March 2021

ntroduction: The Covid-19 pandemic has left a serious impact on the lives of people globally. One key social consequence of the infection has been the stigma associated with it. Objectives: This study was conducted to explore the lived experiences of stigma among persons who have recovered from Covid-19 in Chennai, India. Methods: In depth telephonic interviews were conducted among 12 persons who had recovered from Covid-19 in Chennai. The participants were encouraged to narrate their experiences of stigma. The telephonic interviews were transcribed and coded by both the researchers. The codes were then grouped into meaningful themes and the lived experiences of stigma described with the help of rich narrative quotes. Results: The common manifestations of stigma were exclusion from public spaces and essential services, loss of livelihood, loss of social support and, in an extreme case, physical violence. The stigma was also manifested in health facilities in the form of neglect, and rude and insensitive treatment of patients. The factors that aggravated the stigma included fear of infection, lack of information, legitimisation of segregation by forced public health interventions, involvement of police in contact tracing, and isolation. Stigma was associated with psychosocial consequences such as loneliness, uncertainty, anxiety, anger, and humiliation. Demonstration of empathy, advances in communication technology, solidarity in communities and protecting confidentiality could potentially mitigate stigma. The intersectionality of age, gender, poverty, and disability worsened the experience of stigma. Conclusions: People who had recovered from Covid-19 experienced various degrees of social stigma. The future impact of the pandemic will depend strongly on the ability of health systems to address stigma.
Rare diseases – a challenge for the medical world
Authors: Bokayeva Kamila , Miraleyeva Alua , Walkowiak Dariusz
Published: March 2021

The diagnosis and treatment of rare diseases have improved significantly in recent years. The length of the diagnosis, which from the point of view of patients and their caregivers was considered the "Achilles' heel" of the healthcare system, has significantly shortened in many cases. Nevertheless, as research shows, there is still much to be done regarding the knowledge of rare diseases among healthcare professionals. The processes of diagnosis and treatment, as well as their organisation, should be redefined.
Ten Simple Rules for Implementing a Flipped Classroom
Authors: Taly Antoine , Poulain Pierre , Dufour Héloïse , Bertrand Mickaël
Published: March 2021

This manuscript aims to share some tips on implementing a flipped classroom, with examples from biology and computational biology. The proposed rules are: - Invert time and Say It, - Identify (or create) resources for learning at home, - Be explicit on the acquisition of knowledge and engage students at home, - Explore active learning in class, - Develop skills of cooperation and sharing, - Evaluate, - Differentiate, - Take care of the logistic and your posture, - Document your flipped classroom, - Share.
Small Symmetrical Deformation of Thin Torus with Circular Cross-Section
Authors: Sun Bohua
Published: March 2021

By introducing a variable transformation $\xi=\frac{1}{2}(\sin \theta+1)$, a complex-form ordinary differential equation (ODE) for the small symmetrical deformation of an elastic torus is successfully transformed into the well-known Heun's ODE, whose exact solution is obtained in terms of Heun's functions. To overcome the computational difficulties of the complex-form ODE in dealing with boundary conditions, a real-form ODE system is proposed. A general code of numerical solution of the real-form ODE is written by using Maple. Some numerical studies are carried out and verified by both finite element analysis and H. Reissner's formulation. Our investigations show that both deformation and stress response of an elastic torus are sensitive to the radius ratio, and suggest that the analysis of a torus should be done by using the bending theory of a shell.
Comparative Study of Biological Characteristics, and Osteoblast Differentiation of Mesenchymal Stem Cell Established From Camelus Dromedaries Skeletal Muscle, Dermal Skin, and Adipose Tissues
Authors: Son Young-Bum , Jeong Yeon Ik , Jeong Yeon Woo , Hossein Mohammad Shamim , Tinson Alex , Singh Kuhad Kuldip , Hwang Woo Suk
Published: March 2021

Mesenchymal stem cells (MSCs) showed in vitro mesoderm-lineage differentiation and self-renew capacity. However, no comparative study was reported on the biological characteristics of stem cells derived from skeletal muscle (SM-MSCs), dermal skin (DS-MSCs), and adipose tissues (A-MSCs) from a single donor in camels. The present study aimed to evaluate the influence of MSCs source on stem cell characteristics. We evaluated proliferation capacity and mesoderm-lineage differentiation potential from SM-MSCs, DS-MSCs, and A-MSCs. They showed spindle-like morphology after homogenization. The proliferation ability was no significant difference in all groups. Furthermore, the portion of the cell cycle and expression of pluripotent markers (Oct4, Sox2, and Nanog) were similar in all cell lines at passage 3. The differentiation capacity of A-MSCs into adipocytes was significantly higher than that of SM-MSCs and DS-MSCs. However, the osteoblast differentiation capacity of A-MSCs was significantly lower than that of SM-MSCs and DS-MSCs. Additionally, after osteoblast differentiation, the ALP activity and calcium content was significantly decreased in A-MSCs as compared to SM-MSCs and DS-MSCs. To the best of our knowledge, we primally established MSCs from the single camel and demonstrated their comparative characteristics including expression of pluripotent factors and proliferation, and in vitro differentiation capacity into adipocytes and osteoblasts.
The Impact of Perceived Hapkido Service Quality on Exercise Continuation and Recommendation Intentions, with a Focus on Korean Middle and High School Students
Authors: Park Tae-Seung , Kim Jun-Su , Kim Jiyoun
Published: March 2021

This research analyzed the impact of quality of service as perceived by Hapkido students on their exercise continuation and recommendation intentions. It also identified the measures to reduce the rate of student dropout, strengthen competitiveness, and create more efficient marketing strategies for consumer patterns that are rapidly diversifying Hapkido. A questionnaire survey method was conducted with 300 middle and high school students aged 14–19 years having Hapkido training of three months to two years in Incheon and Bucheon during March–April 2019. Frequency, factor, reliability, correlation, and standard multiple regression analyses were conducted on the surveyed data. The conclusions are as follows. First, considering the impact of service quality on exercise continuation intention, service quality positively affects reliability, personification, and perceptual openness; in terms of possibility, it positively affects typicality, personification, and perceptual openness; and in terms of reinforcement, it positively affects reliability and perceptual openness. Second, examining the impact of service quality on recommendation intention positively affects reliability, personification, and perceptual openness. Third, exercise continuation intention positively affects recommendation intention.
Interferometry Evaluation of Precorneal Tear Film Lipid Layer After Intense Pulsed Light in Evaporative Dry Eye Disease Owing to Meibomian Gland Dysfunction: A Randomized, Single Masked, Sham-Controlled Study
Authors: Song Yilin , Yu Sile , He Xingru , Yang Lanting , Wu Yi , Qin Guanghao , Zhang Qing , Talwar Gagan Deep Singh , Xu Ling , Moore Jonathan E , He Wei , Pazo Emmanuel Eric
Published: March 2021

Background: Inadequate meibomian glands (MGs) secretion can lead to dry eye signs and symptoms. Tear film lipid layer (TFLL) secreted by MGs protects and prevents rapid evaporation of tear film. Our purpose was to assess TFLL alteration and function in patients with evaporative dry eye (EDE) using tear interferometry after optimal pulse light technology (OPT) intense pulsed light (IPL). Methods: This prospective randomized examiner-masked sham- controlled study included 86 participants (142 eyes) with DED. IPL or sham procedure was performed on day 0, 21, and 42. Ocular Surface Disease Index (OSDI), non-invasive breakup time (NITBUT), interferometric fringe pattern determined TFLL quality, fluorescein staining (FS), and meibum gland (MG) were assessed at day 0, 21, 42 and 3-month. Results: At 3-month, TFLL, NITBUT, MG drop-out, MG quality, MG expressibility, FS and OSDI improved significantly (P<0.05) in the IPL group, while the sham group had no significant improvements. All DE parameters significantly correlated with the improvement in TFLL following IPL treatment. Additionally, artificial tears usage was significantly less in the IPL group from D-42 onwards. Conclusion: IPL treatment demonstrated the ability to improve TFLL quality and clinically reduced sign and symptoms of DED thereby reducing the frequency of artificial tears usage.
Liver Proteome Profile of Growth Restricted and Appropriately Grown Newborn Wistar Rats Associated with Maternal Undernutrition
Authors: Sarli Polyxeni-Maria , Manousopoulou Antigoni , Efthymiou Elias , Zouridis Andreas , Potiris Anastasios , Pervanidou Panagiota , Panoulis Konstantinos , Vlahos Nikolaos , Deligeoroglou Efthimios K. , Garbis Spiros D. , Eleftheriades Makarios
Published: March 2021

1) Background: Fetal Growth Restriction (FGR) has been associated with adverse perinatal outcomes and epigenetic modifications that impact gene expression leading to permanent changes of fetal metabolic pathways and thereby influence development of disease in childhood and adult life. Both clinical and experimental studies showed that maternal nutrition during pregnancy is critical since malnutrition adversely affects fetal growth and physiology. In this study, we investigated the result of maternal food restriction on liver protein expression in Wistar male newborn pups. (2) Materials & methods: Pups born to food restricted mothers were subdivided to FGR and non-FGR groups. Livers of control, FGR and non-FGR groups were analyzed using quantitative proteomics. (3) Results: In total 6665 proteins were profiled. Of these, 451 and 751 were differentially expressed in FGR and non-FGR vs. control respectively, whereas 229 were common between the two groups. Bioinformatics analysis of the differentially expressed proteins (DEPs) in FGR vs. control revealed: induction of the super-pathway of cholesterol biosynthesis and inhibition of thyroid hormone metabolism, fatty acid beta oxidation and apelin liver signaling pathway. In the DEPs of non-FGR vs. control groups there was inhibition of thyroid hormone metabolism, fatty acid beta oxidation and apelin liver signaling pathway as well. (4) Conclusion: This study demonstrates the impact of prenatal food restriction on the proteomic liver profile of FGR and non-FGR offspring underlying the importance of both prenatal adversities and birth weight on liver dependent postnatal disease.
The Effects of Plant Growth-Promoting Bacteria (PGPB) Inoculation on Growth, Yield, and Grain Nutrient Uptake of Two Teff Varieties Under Greenhouse Condition
Authors: Tsegaye Zerihun , Bekele Dagne , Chaniyalew Solomon , Feleke Adey , Alemu Tesfaye , Assefa Fassil
Published: March 2021

Application of native PGPR as bio inoculant is an alternative sustainable agricultural practice to enhance crop productivity, grain quality, and soil fertility. In this view, a study was to examine the effect of either individual or consortium PGPR inoculation on growth, yield, and grain nutrient uptake of two teff varieties. The pot experiment was carried out in (CRD) three replication and 10 treatments. The PGPR inoculants used in this study were Pseudomonas fluorescens biotype G, Enterobacter cloacae ss disolvens, and Serratia marcescens ss marcescen and their consortium. Dukem and Magna varieties were used in this study. The results of the analysis of variance showed significant differences (P ≤ 0.001) among the treatment and most of the agronomic traits except number of fertile tillers and also significant different (P ≤ 0.01) for grain P and N uptake. The variety was significantly affected grain Mg, Zn and Fe uptake at 5 % probability level and did not significantly influence all agronomic traits of the two varieties. Furthermore, interaction effects of two factors (TM*VT) were significant differences (P ≤ 0.05) for plant height and panicle length. Individual treatments mean comparison results showed that inoculation of native PGPR consortium significantly affected most of the PGP traits at (P ≤ 0.05). The maximum traits like plant height (189cm), panicle length (66.7cm), shoot dry biomass (9.98g), root dry biomass (2.90g) and grain yield per plant (4.55g) were observed from Dz-01-196. It could be concluded that the consortium of native PGPR inoculants for plant growth, yield and grain nutrient uptake improvement performed better than their individual strain.
A Survey on Bias in Deep NLP
Authors: Garrido-Muñoz Ismael , Montejo-Ráez Arturo , Martínez-Santiago Fernando , Ureña-López L. Alfonso
Published: March 2021

Deep neural networks are hegemonic approaches to many machine learning areas, including natural language processing (NLP). Thanks to the availability of large corpora collections and the capability of deep architectures to shape internal language mechanisms in self-supervised learning processes (also known as "pre-training"), versatile and performing models are released continuously for every new network design. But these networks, somehow, learn a probability distribution of words and relations across the training collection used, inheriting the potential flaws, inconsistencies and biases contained in such a collection. As pre-trained models have found to be very useful approaches to transfer learning, dealing with bias has become a relevant issue in this new scenario. We introduce bias in a formal way and explore how it has been treated in several networks, in terms of detection and correction. Also, available resources are identified and a strategy to deal with bias in deep NLP is proposed.
DRESS Syndrome in a Teenage Male Associated With Hhv-6 Reactivation While on Prolonged TMP-SMX Use
Authors: Conteras Dalia , Pecson Iris , Galvis Alvaro
Published: March 2021

Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS) is a rare and potentially life-threatening systemic drug reaction with skin involvement. We present the unusual case of DRESS in a 16-year-old male that was treated with TMP-SMX for acne and was initially misdiagnosed with Steven Johnson Syndrome. Our case serves as an example to healthcare providers treating adverse drug reactions to having a high clinical suspicion for DRESS as delay in diagnosis and treatment can result in disseminated disease and higher patient mortality risk.
Influence of Traditional and Solar Reflective Coatings on the Heat Transfer of Building Roofs in Mexico
Authors: Hernández-Pérez Iván
Published: March 2021

Building roofs are sources of unwanted heat for buildings situated in zones with a warm climate. Thus, reflective coatings have emerged as an alternative to reject a significant fraction of solar energy received by roofs. In this research, the thermal behavior of concrete slab-type roofs with traditional and solar reflective coatings was simulated using a computational tool. Weather data from four cities in Mexico with a warm climate were used as boundary conditions. This tool is an in-house code based on the Finite Volume Method developed by the author to perform building components simulations. The code was validated with experimental data from previous work. A series of comparative simulations were developed, taking a gray roof as a control case. The results showed that for the roof without thermal insulation (single roof), the solar reflective coatings reduced the exterior surface between 11 and 16∘C. Consequently, the single roofs’ daily heat gain was reduced by a factor ranging between 41 and 54%. On the other hand, for the insulated roof, the reflective coatings reduced the exterior surface temperature between 17 and 21∘C. At the same time, the daily heat gain of composite roofs was reduced between 37 and 56%.
Soil Fertility Management Practices For Faba Bean (Vicia faba L.) Production in Wolaita Zone, Southern Ethiopia
Authors: Abebe Bekalu , Dechassa Nigussie , Tana Tamado , Laekemariam Fanuel , Alemayehu Yibekal
Published: March 2021

Understanding the soil fertility management practices is indispensable to improve faba bean productivity. However, little effort has been made to assess the soil fertility management practices of faba bean producing farmers of Wolaita Zone, southern Ethiopia. The study was conducted in Damot Gale and Sodo Zuria districts in Wolaita Zone to assess farmers’ soil fertility management practices for faba bean production, in 2019 on 310 framers. Faba bean productivity in the studied districts is majorly constrained by the scarcity of arable land, poor soil fertility, and soil acidity. These cumulative effects have caused negative consequences on soil fertility and faba bean productivity. In most soil fertility, management practices in faba bean farm did not significantly vary among the studied districts. The soil management practices by farmers were inadequate to improve soil fertility and to enhance faba bean productivity. Consequently, the average grain productions of both fertilized and unfertilized faba bean farm were far less than the national average. Therefore, intensive soil fertility management interventions such as faba bean residue management, crop rotation, application of sufficient and balanced fertilizers, adequate lime application, screening acidity tolerant varieties are required to improve faba bean productivity. in the studied districts.
A Multiphysics Analysis of Coupled Electromagnetic-Thermal Phenomena in Cable Lines
Authors: Cywiński Artur , Chwastek Krzysztof
Published: March 2021

The paper is focused on numerical modeling of multi-strand cable lines placed in free air. Modeling is carried out within the framework of the so-called multi-physics approach using commercial software. The paper describes in detail the steps undertaken to develop realistic, reliable numerical models of power engineering cables, taking into account their geometries and heat exchange conditions. The results might be of interest to the designers of multi-strand cable systems.
Sensing and Delineating Mixed-VOC Composition in Air Using a Single Metal-Oxide Sensor
Authors: Thakor Govind S. , Zhang Ning , Santos Rafael M.
Published: March 2021

Monitoring volatile organic compounds (VOCs) places a crucial role in environmental pollutants control and indoor air quality. In this study, a metal-oxide (MOx) sensor detector (uRAD A3 mobile air quality monitor) was employed to delineate the composition of air containing three common VOCs (ethanol, acetone and hexane) under various concentrations. Experiments with a single component and double components were conducted to investigate how the solvents interact with the metal oxide sensor. The experimental results revealed that the affinity between VOC and sensor was in the following order: acetone > ethanol > n-hexane. A mathematical model was developed, based on the experimental findings and data analysis, to convert the output resistance value of the sensor into concentration values, which in turn can be used to calculate a VOC-based air quality index. Empirical equations were established based on inferences of vapor composition versus resistance trends, and on an approach of using original and diluted air samples to generate two sets of resistance data per sample. The calibration of numerous model parameters allowed matching simulated curves to measured data. As such, the predictive mathematical model enabled quantifying not only the total concentration of sensed VOCs, but also estimating the VOC composition. This first attempt to obtain semi-quantitative data from a single MOx sensor is aimed at expanding the capability of mobile air pollutants monitoring devices.
The ‘Jekyll and Hyde’ of Gluconeogenesis: Early-Life Adversity, Later Life Stress, and Metabolic Disturbances
Authors: Seal Snehaa V. , Turner Jonathan D.
Published: March 2021

The physiological response to a psychological stressor broadly impacts energy metabolism. Inversely, changes in energy availability affect the physiological response to the stressor in terms of hypothalamus, pituitary adrenal gland axis and sympathetic nervous system activation upon exposure to a stressor. Glucocorticoids, the endpoint of the HPA axis, are critical checkpoints in endocrine control of energy homeostasis. Glucocorticoid actions have been linked to many severe metabolic diseases including obesity, insulin resistance and type 2 diabetes. Glucocorticoids, through the glucocorticoid receptor, activate transcription of many genes associated with glucose and lipid regulatory pathways and thereby intricately control both physiological and pathophysiological systemic energy homeostasis. Here, we summarize the current knowledge of glucocorticoid functions in energy metabolism and systemic metabolic dysfunction, particularly focusing on glucose and lipid metabolism. There are many elements in the external environment that induce lifelong changes in the HPA axis stress response and glucocorticoid levels, the most prominent are early-life adversity, or exposure to traumatic stress. We hypothesise that when the HPA axis is so disturbed after early-life adversity, it will fundamentally alter hepatic gluconeogenesis, inducing hyperglycaemia, and hence crystalise the significant lifelong risk of developing either the metabolic syndrome, or type 2 diabetes. This gives a “Jekyll and Hyde” role to gluconeogenesis, providing the necessary energy in situations of acute stress, but driving towards pathophysiological consequences when the HPA axis has been altered.
Contemporary Mouse Models in Glioma Research
Authors: Hicks William , Bird Cylaina , Abdullah Kalil
Published: March 2021

Despite advances in understanding of the molecular pathogenesis of glioma, outcomes remain dismal. Developing successful treatments for glioma requires faithful in vivo disease modeling and rigorous preclinical testing. Murine models, including xenograft, syngeneic, and genetically engineered models, are used to study gliomagenesis, identify methods of tumor progression, and test novel treatment strategies. Since the discovery of highly recurrent isocitrate dehydrogenase (IDH) mutations in lower-grade gliomas, there is increasing emphasis on effective modeling of IDH mutant brain tumors. Improvements in preclinical models that capture the phenotypic and molecular heterogeneity of gliomas are critical for the development of effective new therapies. Herein, we explore the current status, advancements, and challenges with contemporary murine glioma models.
Triple-Drug Mass Drug Administration is Effective for Lymphatic Filariasis Microfilaria Clearance in Samoa
Authors: Graves Patricia M. , Sheridan Sarah , Scott Jessica , Amosa-Lei Sam Filipina , Naseri Take , Thomsen Robert , King Christopher L. , Lau Colleen L.
Published: March 2021

Following the first triple-drug MDA for lymphatic filariasis in Samoa in 2018, unexpected persistence of Mf-positivity in 18 (15%) of 121 antigen-positive persons was observed in a nationwide household survey 1-2 months later, raising concerns about MDA efficacy. In 2019, a monitored treatment study was done before and 7 days after directly observed weight-based treatment. Mf presence and density were evaluated using 1 mL membrane filtered venous blood, and 60uL thick blood films on slides prepared from venous or fingerprick blood. All 14 participants were still Mf positive on filters from venous blood pre-treatment samples, but two were negative by slide made from the same samples. Mf were cleared completely by day 7 in 12 of 13 participants followed up, and by day 30 in the remaining participant. Filtered blood using EDTA samples (to reduce clumping of Mf) is preferred over slides alone for improving the likelihood of detecting Mf and estimating their density. The triple-drug MDA strategy was effective at clearing Mf by day 30 when given and taken at the correct dose.
Outlooks of photodynamic therapy for the treatment of cervical diseases in routine clinical practice
Authors:   O.K.Skobelkin State Research Center for Laser Medicine, Moscow, Russian Federation, Ryabov M.V. , Mikhaleva L.V. ,   O.K.Skobelkin State Research Center for Laser Medicine, Moscow, Russian Federation, Stranadko E.F. ,   O.K.Skobelkin State Research Center for Laser Medicine, Moscow, Russian Federation, Duvanskiy R.A. ,   O.K.Skobelkin State Research Center for Laser Medicine, Moscow, Russian Federation, Duvanskiy V.A. ,   O.K.Skobelkin State Research Center for Laser Medicine, Moscow, Russian Federation
Published: March 2021

Cervical cancer is one of the most common malignancies. Despite the existence of well-developed classical approaches to prevention, diagnosis, and treatment, cervical cancer demonstrates one of the highest incidence and mortality rates among female cancers. Cervical diseases are widespread, can develop at any age, and often preceded cancer development. Photodynamic therapy (PDT) is a new and unique treatment for cancer and a number of non-malignant diseases, which is based on systemic or topical administration of photosensitizers, followed by laser exposure. We analyzed foreign and Russian articles published between 2004 and 2018 evaluating the efficacy of PDT in patients with precancerous diseases and early cervical cancer. PDT is a highly effective treatment method, which causes no complications and can eliminate human papilloma virus. We assessed potential outlooks of wide clinical use of PDT. Key words: cervical dysplasia, photodynamic therapy, photosensitizer, laser, human papillomavirus
Cervical screening: past, present, and future
Authors:   Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russian Federation, Zarochentseva N.V. , Krasnopolskiy V.I. ,   Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russian Federation, Misyukevich O.A. ,   Territorial Fund of Compulsory Medical Insurance of Moscow Region, Moscow, Russian Federation, Dzhidzhikhiya L.K. ,   Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russian Federation, Dzhavakhishvili M.G. ,   Moscow Regional Research Institute of Obstetrics and Gynecology, Moscow, Russian Federation
Published: March 2021

This review aims to summarize currently available information on cervical screening, including screening programs and efficacy of liquid-based cytology and co-testing. We analyzed relevant foreign and Russian publications available in the Pubmed and eLIBRARY electronic databases. Current screening strategies include mandatory HPV testing and cytological examination. HPV self-sampling tests and immunocytochemical examination of cervical smears for P16/Ki67 are also relevant. Screening programs should cover > 70% of the female population. Key words: CIN, cervical cancer, human papillomavirus, cytological method, co-testing, Pap test, self-sampling test
Congenital heart defects and pregnancy: current view on the mechanisms of placental adaptation to circulatory hypoxia
Authors:   Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation, Rudyuk L.A. , Reshetnikova O.S. ,   Immanuel Kant Baltic Federal University, Kaliningrad, Russian Federation
Published: March 2021

In this review, we perform clinical and morphological analysis of the mechanisms underlying adaptation of the human placenta to hypoxia in the fetoplacental complex in pregnant women with congenital heart defects (CHDs). We assessed specific characteristics of macroscopic and microscopic structure of the placenta in women with this extragenital pathology. We descried morphological involutive dystrophic and compensatory mechanisms that develop in the placenta of women with impaired hemodynamics. We proposed molecular markers, whose investigation will clarify functional state of the placental barrier and ways of remodeling vascular-stromal components of the villous chorion. Potential risks associated with circulatory hypoxia in the mother-placenta-fetus system should be taken into account in the management of pregnant women with CHDs. Detection of placental maladaptation signs in mothers with CHDs will help to identify the risk group of newborns, organize preventive therapy, prophylaxis of diseases, health improvement, and treatment of newborns. Key words: compensatory and adaptive processes, hypoxia, immunohistochemistry, morphology, placenta
Safety of paracetamol during pregnancy: literature review
Authors:   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Lukina M.V. , Andrushchishina T.B. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Dronov I.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Vartanova O.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Yudina I.Yu. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Chukina M.A. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation, Morozova T.E. ,   I.M.Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russian Federation
Published: March 2021

Paracetamol (acetaminophen) is the drug of choice in pregnant women as an antipyretic and analgesic agent for various clinical conditions. However, long-term paracetamol administration during pregnancy was found to be associated with disorders in children, such as attention deficit hyperactivity disorder (RR = 1.32, 95% CI 1.18–1.45, I2 = 61%); autism spectrum disorders (RR = 1.23, 95% CI 1.13–1.32, I2 = 17%); hyperactivity disorder (RR = 1.24, 95% CI 1.02–1.46, I2 = 95%), and behavioral disorders (RR = 1.28, 95% CI 1.05–1.52, I2 = 94%). Studies conducted so far failed to identify the effect of paracetamol dose in different trimesters of pregnancy on the development of long-term functional disorders of the central nervous system in children. Further studies are needed to assess the importance of social factors and the environment and their contribution to the development of functional disorders of the central nervous system in children. Key words: acetaminophen, safety, pregnancy, neuropsychiatric development of children, paracetamol