bluuebunny/crossref_metadata_2025 huggingface dataset:
A mental health outreach program in child welfare centre with homoeopathy
Authors: Muraleedharan K. C. , Moorthi S. K. , Gilla Deepthi
Published: July 2023

Mental health problems during childhood and adolescence are a major health concern globally. Children in welfare centres pose varied emotional and behavioural problems (EBP) and need special treatment with a multidisciplinary approach. Homoeopathy has an evidence base for effectiveness in the management of some behavioural problems in children. Objective was to evolve the approach to mental health intervention using homeopathic medicines in the management of behavioural issues in children at a child welfare centre (CWC) through an outreach initiative. A screening program was conducted on 46 children at a child welfare centre, out of which 20 children were diagnosed with mental health issues according to ICD-10 criteria. These children were treated with individualised homoeopathic medicines and are followed up in regular intervals to assess the changes in behaviour of children after homoeopathic intervention. 3 cases of conduct disorders are illustrated to show the constitutional approach in children with behavioural problems. Causal attribution to the outcome after intervention are described as per Monarch criteria. 85% of cases were found to have moderate to marked improvement after 1 year of treatment. The remedies indicated are Sulphur (6), Carcinosinum (3), Natrum Mur (3), Silicea (2), Lachesis, Lycopodium, Merc Sol, Phosphorus, Staphysagria and Tarantula hispanica. Individualized homoeopathic medicines are found to be useful in the management of EBP of children in CWC. This preliminary mental health outreach serves as a model for future pragmatic research. Studies with appropriate study designs focussing on specific behavioural problems in juvenile delinquents are suggested.
Effectiveness and safety of bronchodilators and inhaled corticosteroids in the management of chronic obstructive pulmonary disease
Authors: Shalabi Mona Saleh , Aqdi Sameerah Waheed , Alfort Odai Ali , Alqattan Hassan Abdullah , Alotaibi Fuad Abdulrahman , Faruqui Afnan Mohammed , Alharbi Abrar Saleh , Alzahrani Faisal Fahad , Yahya Sultan Ahmed , Bakheet Alaa Abdulrahman , Al Mohammedali Najeeb Mansour , Al-Ghamdi Hamed Saeed
Published: July 2023

Chronic obstructive pulmonary disease (COPD) is a lung condition marked by restricted lung airflow. It is a globally prevalent condition affecting almost 300 million individuals. COPD is linked to a significant burden of morbidity and mortality thus necessitating early diagnosis and management. Rising COPD treatment options complicate care and necessitate a review of clinical data to guide treatment choices. Corticosteroids and bronchodilators are the mainstay of treatment for COPD due to their safety and efficacy. Compared to inhaled corticosteroids or long-acting β-agonist therapy alone, inhaled corticosteroids plus long-acting β-agonist lower the risk of exacerbations and enhance lung function and health status in patients with COPD. Patients who experience frequent exacerbations despite taking long-acting bronchodilators and those who have evidence of eosinophilic bronchial inflammation, as shown by high blood eosinophil levels and/or a history of asthma or asthma-COPD overlap, may both benefit greatly from inhaled corticosteroids therapy. Although not widespread, inhaled corticosteroid use is linked to an elevated risk of pneumonia and may vary depending on the particular corticosteroid utilized. Recent research on combination therapy of inhaled corticosteroids and long-acting β-agonist has shown significant advantages and supports its widespread use in COPD patients who experience frequent exacerbations however some clinical studies and trials have also demonstrated quite conflicting outcomes to this therefore necessitating the need for further clinical trials to exhibit conclusive results. The purpose of this research is to review the available information about the effectiveness and safety of bronchodilators and inhaled corticosteroids in the management of COPD.
Indications, design considerations, and clinical outcomes of implant-supported fixed prostheses
Authors: Alfaer Ali Salem , Bakhsh Khulood Khalid , Alyami Ibrahim Mohammed , Fallatah Rawaa Mohammed , Saloum Mashael Saleh , AlHarbi Nouf Yahya , Al Otaibi Suha Dhaifallah , Alotaibi Bandar Zaid , AL Meheini Salem Abdullah , AL Shalawi Sahar Safar , Bushnaq Abdulrahman Mohammed
Published: July 2023

Implant-supported fixed prostheses are a highly successful treatment option for replacing missing teeth, offering improved esthetics, function, and patient satisfaction. Design considerations play a crucial role in achieving optimal outcomes. Implant distribution and angulation should be carefully planned to ensure balanced load distribution and biomechanical stability. Occlusal considerations are vital to minimize mechanical complications and implant overloading, with proper adjustments and occlusal schemes implemented. The emergence profile should replicate natural tooth contours for esthetic integration and ease of oral hygiene maintenance. Material selection is essential, considering factors such as occlusal loading, esthetic requirements, and patient-specific considerations. Biomechanical analysis helps identify stress distribution patterns and optimize prosthesis design for long-term success. Patient satisfaction is high, with improved chewing ability, speech, and overall quality of life reported. Long-term success rates exceed 90%, influenced by implant survival, peri-implant health, maintenance of prosthesis integrity, and patient satisfaction. Thorough patient assessment, treatment planning, precise surgical and prosthetic execution, and comprehensive follow-up care are crucial for favorable outcomes. Implant-supported fixed prostheses provide functional and esthetic restorations, enhancing oral health and overall well-being.
Phases, evaluation and treatment of acute renal tubular necrosis
Authors: Baddour Najlaa Matouq , Beragdar Mishari Mohammad , Bagais Khaled Hussein , Alattas Khalid Abdullah , Morad Muaid Hashem , Aljunaid Muataz Abdulmoghni , Alazwari Naif Mishkhas , Alsolami Abdulilah Ateeq , Aljiffry Mohammed Omar , Yahya Mohammed Omar , Alenazi Hanadi Halil
Published: July 2023

Acute renal tubular necrosis (ATN) is a severe kidney injury characterized by the death of renal tubular cells, resulting in impaired kidney function. This condition is associated with high morbidity and mortality rates, necessitating effective management strategies. This article provides a comprehensive overview of the evaluation and management of ATN. The evaluation process involves a combination of clinical assessment, laboratory investigations, and imaging modalities to confirm the diagnosis, identify the underlying cause, and assess the severity of the renal injury. The management of ATN encompasses addressing the underlying cause, providing supportive care, and preventing complications. This includes pharmacological interventions, fluid management, electrolyte balance, and renal replacement therapy in severe cases. Patient education, close monitoring, and preventive measures play critical roles in optimizing outcomes. Understanding the phases of ATN, including initiation, maintenance, and recovery, is essential to tailoring management strategies. Further research is needed to advance diagnostic modalities, therapeutic interventions, and preventive strategies for ATN, leading to improved patient outcomes.
Evaluation and management of acute epistaxis in the emergency department
Authors: Abduljabbar Ashraf Abdulaziz , Abdulmahdi Abdulla Khalaf , Alalshojaa Asma Yahia , Alfaier Mohammed Qhalib , Almasuai Ahmed Hassan , Alfadley Abdulaziz Fadel , Alkanderi Roaa Ali , Alyousif Amal Yasir , Alabdullatif Ghaith Saleh , Almuaddi Abdulrahman Saeed , Alkurdi Abdullah Ahmad
Published: July 2023

Acute epistaxis, or nosebleed, is a common presentation in the emergency department (ED) that requires a systematic evaluation and prompt management. The assessment involves considering the severity of bleeding, identifying underlying causes, and implementing appropriate interventions. Modifiable risk factors, such as medication review, nasal hygiene, avoidance of nasal trauma, and humidification, should be addressed to prevent recurrence. Referral to specialists is necessary for cases of recurrent or severe bleeding, suspected underlying causes, or inadequate response to initial management. Collaboration between ED healthcare providers and specialists ensures comprehensive evaluation, specialized interventions, and long-term management. Regular follow-up appointments and patient education are essential for monitoring progress, adjusting treatment, and preventing complications. By employing a comprehensive approach, healthcare providers aim to alleviate distress, achieve hemostasis, identify underlying etiologies, and optimize patient outcomes in the ED.
Comparison of various pulpotomy techniques: coronal, cervical, and full pulpotomy
Authors: Alamri Abdulrahman Saeed , Alqurashi Asem Mustafa , Alotaibi Fatimah Ayedh , Alghamdi Ziyad Saleh , Salamah Samar Khalid , Alenezi Majed Awad , Almutairi Waad Majed , Almutairi Amjad Majed , Alabbasi Daliya Mohammed
Published: July 2023

The preservation of deciduous teeth is crucial in pediatric dentistry to maintain normal speech, development, and self-esteem, while also preventing secondary issues like space loss and tooth impaction. Different materials and approaches have been explored over time, ranging from mummification to maintaining pulp vitality and promoting healing. In today's conservative dentistry, techniques like indirect pulp treatment and partial pulpotomy (PP) have gained popularity. Adults diagnosed with irreversible pulpitis due to deep caries often receive root canal therapy (RCT). However, coronal pulpotomy treatment (CPT) has emerged as an affordable alternative for those unable to afford RCT. CPT removes the coronal pulp, allowing the remaining pulp to remain vital. PP and complete pulpotomy are explored as treatments for teeth with signs of irreversible pulpitis. Success depends on eliminating infected tissue, using aseptic techniques, and achieving a tight restorative seal. Materials like MTA have shown favorable outcomes. Direct pulp therapy and PP can effectively preserve vital pulp in primary and young permanent teeth. The choice of pulpotomy material, such as MTA, plays a significant role in success rates.
What do we know as far as the intersection of gender and malaria control in sub-Saharan Africa is concerned? A narrative review
Authors: Madindé Jeanne , Karl Nassi , AKPI Eric , Abou-Bakari Imorou
Published: July 2023

In terms of the goals of the United Nations, several sub-Saharan countries aim at annihilating malaria by the year 2030. However, achieving such an objective requires strategies based on evidence and adapted to the context of vulnerability in which each of these countries operates. This narrative review provides evidence that there is a significant interdependence between gender and malaria that has to be taken in account. It identifies a significant gap in the availability of data on this interdependence and climate change which, moreover, is another phenomenon that disproportionately affects men and women and is susceptible to other complex inequalities. Challenges with regard to an interdisciplinary perspective as well as the design of an integrated conceptual framework for the study of the dynamics between gender, malaria and climate change remain and challenge researchers on the continent.
Strength, weaknesses, opportunities, and threats analysis on the current scenario of primary health care in India
Authors: Konki Akshitha , Pachava Srinivas , Pavani Nijampatnam P. M. , Bhavani Vasamsetti Divya
Published: July 2023

The Indian public health system is organized as a three-tiered pyramid, with primary, secondary, and tertiary healthcare facilities. The cornerstone of healthcare delivery anywhere in the world is primary care. Even after primary healthcare reform, problems with poor infrastructure and a serious lack of medical staff and resources continued throughout time. The whole foundation of this study is secondary data acquired from various government publications, journals, and press releases retrieved from databases like google scholar, PubMed, science direct, and search engines like Google. An analysis of strengths, weaknesses, opportunities, and threats (SWOT) was carried out using the structure and dynamics of primary healthcare systems as well as literature searches. Upgrades should be made to PHC delivery service facilities, newer housing should be built to meet population expansion demands, and a bottom-up strategy should be employed with a focus on community empowerment, illness prevention, and health promotion.
Incorporation of graphene oxide and reduced graphene oxide on the performance of hybrid polysulfone membranes for gas permeation
Authors: Gilioli Tosin Laís , Silvestre Wendel Paulo , Baldasso Camila
Published: July 2023

Polymeric membranes with the addition of graphene and derivatives are being studied due to the impacts on the physical-chemical and separation properties of these membranes. In this study, polysulfone (PSU) membranes containing graphene oxide (PSU/GO) and reduced graphene oxide (PSU/RGO) were developed at a concentration of 0.5 wt.%, to compare their characteristics and physical-chemical properties. Membrane morphology was evaluated by SEM, thermal stability by TGA/DTG, functional groups and material structure by FTIR, and mechanical properties by pressure test and gas permeation test using synthetic air. Agglomeration of GO and RGO was verified, a factor that may have interfered with the performance of the membranes. There was no change in thermal stability of the membranes with the presence of GO/RGO nor the occurrence of new bands observed in FTIR spectra, indicating that the interactions between PSU and GO/RGO were physical. All membranes resisted the maximum system pressure (6 bar), and it was not possible to identify whether the addition of graphene-derived materials had a positive effect on the mechanical strength. PSU/GO membranes had a better performance regarding synthetic air permeability during the gas permeation test than PSU and PSU/RGO membranes, possibly due to the functional groups present in GO.
80 years of Vladislav A. Tsarev
Authors:   Yuri Gagarin State Technical University of Saratov, Miroshnichenko Aleksey
Published: July 2023

August 3, 2023 is the 80th anniversary of Vladislav Alekseevich Tsarev.
Technical Problems and Ethical Concerns Regarding Gene Editing in Human Germlines and Embryos
Authors: Sadeghi Mohammad Reza
Published: July 2023

The Article Abstract is not Available.
Comparison of Diff-Quick and Spermac Staining Methods for Sperm Morphology Evaluation
Authors: Farias Junior Lincoln Bastos , Da Cunha Barreto-Vianna André Rodrigues , De Mello Mariana Duque , Dos Santos Alexandre Leseur , Fonte Ramos Cristiane da , Fontoura Paula
Published: July 2023

Background: The objective of the current study was comparing the impact of two staining techniques on semen morphological parameters and their influence on patient diagnosis. The ideal staining method should preserve cell integrity while providing detailed information.
Methods: Semen samples from fifty men were stained using Diff-Quick or Spermac methods. Morphological parameters were classified based on the Tygerberg criteria, and final diagnosis was according to WHO manual guidelines. Statistical analysis was performed through conducting paired t-tests or Wilcoxon rank-sum tests, with GLIMMIX and Fisher's exact test for determining the significance (p≤0.05).
Results: Both staining methods highlighted head and tail regions, with Spermac offering better visualization of the midpiece. Spermac demonstrated fewer normal spermatozoa (2.8±0.3%) compared to Diff-Quick (3.98±0.4%; p=0.0385). Midpiece abnormalities were more evident with Spermac (55.7±2.1%) than Diff-Quick (24.8±2.0%; p<0.0001). No significant difference was found in head and tail abnormalities (p>0.05).
Conclusion: Diff-Quick staining resulted in a higher proportion of normal spermatozoa, primarily due to its midpiece evaluation. The choice of staining method significantly impacts the diagnosis of infertile males. These findings have important implications for clinical practice and future research, suggesting the need for further investigations to assess different staining methods and determine optimal diagnostic thresholds.
Sox2 Localization During Spermatogenesis and Its Association with other Spermatogenesis Markers Using Protein-Protein Network Analysis
Authors: Reza Emad , Azizi Hossein , Skutella Thomas
Published: July 2023

Background: Sox2 (SRY box2) is an essential transcription factor that plays a vital role in spermatogenesis and regulates the genes in this process. Sox2 is important for pluripotency, self-renewal, and even spermatogonial stem cell differentiation. This gene is found in pluripotent and specialized cells, and it is involved in their biological activities.
Methods: Protein-protein interaction (PPI) network analysis was performed during spermatogenesis using NCBI, STRING, and Cytoscape databases. Then, after isolating spermatogonial stem cells from 6 C57BL/6 mice, mouse embryonic stem cells and ES-like cells were prepared. In the following, Sox2 expression was examined in differentiated and undifferentiated spermatogonia by immunohistochemistry (IMH), immunocytochemistry (ICC), and Fluidigm PCR (polymerase chain reaction). Finally, the results were compared using the Kruskal-Wallis and Dunn tests at the significance level of p<0.05.
Results: The results of this experiment showed that contrary to expectations, Sox2 has cytoplasmic expression in undifferentiated cells and nuclear expression in differentiated cells in in vitro conditions. In addition, the expression of Sox2 increased during differentiation. Fluidigm PCR showed a significantly higher expression of Sox2 (p<0.05) in differentiated compared to undifferentiated spermatogonia. Sox2 has an interaction with other genes during spermatogenesis such as Oct4, Nanog, Klf4, Stra8, Smad1, Tcf3, and Osm.
Conclusion: Sox2, which is known as a pluripotency marker, has a vital role in spermatogenesis and could be a differential marker. Sox2 has strong connections with other genes such as Oct4, Nanog, Klf4, Tcf3, Osm, Stra8, Lim2, Smad1, Gdnf, and Kit.
Follicle Stimulating Hormone (FSH) as a Predictor of Decreased Oocyte Yield in Patients with Normal Anti-Müllerian Hormone (AMH) and Antral Follicle Count (AFC)
Authors: Marie Miller Colleen , Melikian Ryan Elizabeth Margaret , Jones Tiffanny LaTrice , Purdy Mackenzie Phyllice , Khan Zaraq , Lee Bleess Jessica , AnNella Stewart Elizabeth , Coddington Charles Campbell , Shenoy Chandra Camilla
Published: July 2023

Background: The purpose of the current study was to determine the utility of early follicular phase follicle-stimulating hormone (FSH) testing in patients undergoing in vitro fertilization (IVF).
Methods: This was a retrospective review of patients from 2012 to 2015 at Mayo Clinic in Rochester, Minnesota, USA. Included subjects had a normal anti-Müllerian hormone (AMH) of 1 to 9 ng/ml and antral follicle count (AFC) of 10 to 29. Patients were stratified by FSH level when associated estradiol was less than 50 ng/ml. In total, 225 patients were categorized into three groups: high FSH (FSH ≥10 IU/L; n= 36), normal FSH (>5 IU/L and <10 IU/L; n=170), and low FSH (FSH ≤5 IU/L; n= 19). ANOVA and multiple logistic regression were used for statistical comparisons and for evaluation of the relationships between variables; significance level was set at <0.05.
Results: There were no significant differences in demographics, IVF cycle type, or peak estradiol level between the groups. Patients with a high basal FSH level had a similar clinical pregnancy rate and live birth rate compared to controls and patients with low FSH. High FSH level was associated with decreased follicular development (17 versus 22; p<0.01), oocyte yield (15 versus 18; p=0.02), and embryo yield (8 versus 10; p=0.04) despite higher total doses of gonadotropins.
Conclusion: Patients with normal AMH and AFC levels could be further stratified into lower responders and starting doses of medications can be adjusted based on high basal FSH levels. Therefore, it is suggested to counsel patients on pregnancy outcomes which seem to be quite similar regardless of the FSH level.
Increased Risk of Infertility in Women Infected with Human Papillomavirus
Authors: Heidari Pebdeni Parastou , Saffari Fereshteh , Mollaei Hamid Reza , Mirshekari Toraj Reza , Hosseini  Sadat Robabeh , Habibzadeh Victoria , Saeed Lida , Taheri Soodejani Moslem , Ahmadrajabi Roya
Published: July 2023

Background: Among several causes of infertility, urogenital infections seem to be influencing factors. The effect of bacterial or viral sexually transmitted infections (STIs) on human fertility is not well understood. The aim of this study was to determine the frequency of STIs in cervical samples of infertile and fertile women and study the relationship between these agents and infertility.
Methods: In this case-control study, cytobrush was used for collecting of cervical sample from each infertile and fertile woman (n=95) who attended Research and Clinical Centers for Infertility in Kerman, Iran. PCR and real-time PCR methods were used to detect the presence of bacterial (genital Ureaplasma species, genital Mycoplasma species, Chlamydia trachomatis (C. trachomatis), and Gardnerella vaginalis) and viral (herpes simplex virus, human papillomavirus (HPV), and Epstein-Barr virus) agents, respectively. Fisher's exact test and the logistic regression with the significance level of ≤5% were used for statistical analyses.
Results: In general, 78.94% and 14.73% of specimens were positive for one or more studied microorganisms, respectively. Among studied agents, only the infection with HPV was significantly different between infertile and fertile groups (p=0.005) which may enhance the likelihood of female infertility (OR=5.30, 95% CI:1.47-19.11, p< 0.05). After adjusting for age, irregular menstrual cycle, abnormal vaginal discharge, and ectopic pregnancy, the odds ratio of infertility in HPV-infected women increased (OR=7.02, 95% CI:1.52-32.3, p<0.05).
Conclusion: Since HPV infection is asymptomatic, periodic screening of women in reproductive age especially infertile couples is recommended for early diagnosis and prevention of infection progression and cross contamination.
Methemoglobinemia after local anesthesia with prilocaine in adults: four case reports
Authors: YILMAZ Meltem , İŞCAN Arif , MUTLU Levent
Published: July 2023

Methemoglobinemia is a serious hematological disease characterized by the incapability of sufficient oxygen delivery to tissues and cyanosis when iron within hemoglobin in ferrous form (Fe+2) is oxidized to ferric form (Fe+3). Methemoglobinemia may be congenital or acquired. While prilocaine-induced methemoglobinemia can be seen in newborns and early pediatric ages, it is a rare condition in adults. We aimed to investigate prilocaine-induced adult methemoglobinemia with four cases.
Modified Algorithm of the Vector Magnetic Hysteresis 3D Model Applied to the Spatial Integral Equations Method
Authors: Podbereznaya I.B. , Pavlenko A.V. , Batishchev D.V. , Kramarov A.S.
Published: July 2023

The paper proposes mathematical models of the scalar and vector magnetic hysteresis to solve the problems of calculating the three-dimensional magnetic field in electrical devices by the method of spatial integral equations. A system of spatial integral equations is presented describing processes in the electrical devices. Basic and modified algorithms of the Jiles --- Atherton scalar model implementation are considered. The model parameters were tuned using a genetic algorithm. Algorithms for constructing the Jiles --- Atherton direct and inverse vector model in the three-dimensional setting were presented in accordance with the Mayergoyz approach. Generalized model of the vector 3D hysteresis makes it possible to describe the nonlinear properties of ferromagnetic medium for the isotropic and anisotropic materials. An example of the magnetic system calculation is provided taking into account the vector magnetic hysteresis. The simulation model parameters were determined from experimental data of the limited scope. Adequacy of the computational models was checked using a test problem. Results of the numerical studies demonstrated that the models were quite accurately reproducing real hysteresis dependences for various ferromagnetic materials. Proposed models and numerical algorithms implementing them were used as the component models that specified nonlinear characteristics of the magnetic materials in a software package that implemented the spatial integral equations method
Asymptotic Behavior of the Eigenvalues of the Laplacian with Two Distant Perturbations on the Plane (the Case of Arbitrary Multiplicity)
Authors: Golovina A.M.
Published: July 2023

The Laplacian with a pair of distant perturbations is studied in two-dimensional space. Perturbations are understood as real finite continuous potentials. The discrete spectrum of the perturbed Laplacian is studied when the distance between the potentials increases. The presence of its eigenvalues and eigen-functions that correspond to them is considered for various cases of multiplicities of the limiting eigenvalue. The first case of the considered multiplicity is the double limiting eigenvalue. By this we mean the simple and isolated Laplacian eigenvalue with the first potential, as well as the simple and isolated Laplacian eigenvalue with the second potential. The second case under consideration is the case of arbitrary multiplicity of the limiting eigenvalue. By this we mean the Laplacian eigenvalue with the first potential of arbitrary multiplicity and the Laplacian eigenvalue with the second potential also of arbitrary multiplicity. In both cases under consideration (of multiplicity two and arbitrary), the first terms of formal asymptotic expansions of the eigenvalues and eigenfunctions of the perturbed Laplacian are constructed. A complex exponential-power structure of the constructed asymptotic is demonstrated. Also, in both cases under consideration, symmetry with respect to zero of the first corrections of the asymptotics of the eigenvalues of the perturbed Laplacian is shown
REFLEXÕES SOBRE CENÁRIOS DE APRENDIZAGEM COM O AUXÍLIO DE OBJETOS DIGITAIS
Authors: Oliveira Izabel Cristina Barbosa de Oliveira , Wunsch Luana Priscila , Cruz Melanie Bordignon da , Nikolay Liamara da Cunha
Published: July 2023

Práticas pedagógicas mediadas pelas tecnologias digitais da informação e comunicação e o uso dos objetos digitais formam um terreno de constante interesse para pesquisadores da área de educação por estarem sempre guiando profundas transformações no viver e atuar dos alunos e, consequentemente, no do docente. Esta afirmativa tornou-se ainda mais expressiva com as necessidades educacionais destacadas no período pandêmico de COVID-19, e a pesquisa aqui apresentada segue nessa perspectiva. Com o objetivo central de entender como foram utilizados os objetos digitais de aprendizagem, em prol da otimização da aprendizagem dos estudantes da Educação Básica, durante o período de crise, o estudo foi desenhado por meio de uma revisão sistemática de literatura sobre a temática com recorte temporal pré e durante período pandêmico, a fim de conhecer se houve alterações deste uso. Os dados analisados mostram que, sem planejamento, aplicação e avaliação contextualizados nas atuações dos docentes e dos discentes, os objetos digitais de aprendizagem podem perder sua capacidade de auxiliar no processo de aquisição do conhecimento e atuarem apenas como meros recursos de entretenimento. Esse redescobrir e reaprender constante por parte dos professores é um movimento contínuo. O planejamento pedagógico, com a disponibilização de um objeto, deve ser pensado e repensado para haver um sincronismo e um efetivo aproveitamento entre ele e o conteúdo a ser trabalhado.
REALIDADE MISTA: possibilidades pedagógicas na educação
Authors: Viana Jailson Antonio Ribeiro , Abdalla Mariana Libero , Zanetti Amilson Carlos , Marques Stela Maria Fernandes
Published: July 2023

A busca de alternativas para tornar as aulas mais criativas e motivantes para o aluno tornou-se um desafio aos professores. A tecnologia educacional, com sua variedade de ferramentas, surge como um caminho viável e eficaz a uma nova concepção de ensino e aprendizagem no século XXI. Os alunos já nascem e possuem intimidade com as Tecnologias Digitais de Informação e Comunicação — TDICs, ou seja, possuem bastante naturalidade com os instrumentos tecnológicos. Nesse sentido, as escolas estão cada vez mais apostando nesse novo cenário tecnológico, unindo o pedagógico às ferramentas digitais. A realidade mista é a junção da realidade virtual com a realidade aumentada e, com isso, traz novas formas e caminhos de mediar o ensino escolar, aparecendo como alternativas inovadoras e estimulantes à aprendizagem em sala de aula. O objetivo do estudo é discutir e refletir como uma ferramenta tecnológica pode possibilitar uma aprendizagem mais significativa para os alunos e professores. A metodologia baseia-se em pesquisa bibliográfica, com abordagem qualitativa dos dados, baseados em estudos evidentes e reflexões dos autores. Concluiu-se que a RM na educação pode possibilitar inovações pedagógicas e favorecer uma comunicação entre professores e alunos, por apresentar dinâmicas e evidenciar a realidades dos alunos, permitindo aos participantes se sentirem incentivados a buscarem o conhecimento, sendo recompensados por sua dedicação.
“BRINQUEDOTECA VIRTUAL”, “SALA BETHA” E LABORATÓRIOS VIRTUAIS: práticas inovadoras em um curso de Pedagogia EaD
Authors: Santos Danielle Aparecida do Nascimento dos , Uchelli Janiele de Souza Santos , Bezerra Janaina Pereira Duarte
Published: July 2023

Neste artigo, são compartilhadas as experiências de práticas inovadoras em um Curso de Licenciatura em Pedagogia na modalidade de Educação a Distância (EaD), realizadas por meio: da criação e uso de uma Brinquedoteca Virtual; da experiência imersiva no ensino de Ciências nos anos iniciais em uma Sala “Betha”, cujo objetivo é proporcionar o desenvolvimento de atividades pedagógicas e gamificação por meio de realidade aumentada, realidade virtual, infográficos 2D, 3D e 4D e mesa interativa; e do uso de um Laboratório Virtual de prática de Educação Infantil, no eixo de Educação Infantil “Corpo e Movimento”. As tecnologias digitais são reconhecidamente grandes aliadas não só da modalidade EaD, como também dos diferentes níveis e modalidades de educação formal, não formal e informal. Formar professores de Educação Infantil e de Educação Básica, em uma perspectiva de uso de tecnologias digitais, pode ser uma forma de favorecer a análise e atuação sobre a realidade da educação e da sociedade. Diante disso, os resultados das experiências denotam que foi possível proporcionar, na formação inicial em Pedagogia EaD, o acesso e a análise de recursos de tecnologia digital atrelados ao planejamento e execução de práticas pedagógicas, favorecendo a instrumentação intelectual, cultural e tecnológica para o desempenho de funções e papéis nos espaços escolares e não escolares, bem como aprimorando as estratégias de formação e ação docente.
FORMAÇÃO EMPREENDEDORA COMO DEMANDA DA SOCIEDADE DO DIGITAL: possibilidades a partir do metaverso educacional
Authors: Santos Junior Veríssimo Barros dos , Diniz Neto Alberto Joaquim Goveia , Aquino Bruno de Oliveira , Bottentuit Junior João Batista
Published: July 2023

O presente artigo tem como objetivo trazer questões sobre a formação empreendedora, sendo mediada no contexto da sociedade do digital. Além disso, são apresentados os desafios e propostas alternativas para que essa mediação seja condizente e significativa para o aluno, em uma visão da Educação a partir dos conceitos do metaverso. Para tanto, partiu-se de uma contextualização sobre o conceito de empreendedorismo e sua importância social e econômica. Verificou-se ainda que, apesar do empreendedorismo ser amplamente discutido, percebe-se que há em alguns casos desentendimento sobre a amplitude do termo. Em seguida, é discutida a sociedade do digital e os desafios dos empreendedores inseridos nesse contexto, onde o “novo” é atualizado a cada segundo. A partir da análise, conclui-se que é fundamental inserir ao longo da formação empreendedora as TIC que permitem simular as atividades e situações-problemas encontradas no mercado atual.
Morphoimmunohistochemical changes in the coronary arteries early after stenting
Authors: Todorov Sergey S. , Todorov Sergey S. , Deribas Victoria Yu. , Kazmin Artem A.
Published: July 2023

Introduction: Modern methods of surgical treatment for coronary heart disease include stenting and bypass surgery. In this regard, a morphoimmunohistochemical study of the state of the coronary arteries in the early stages after stenting will make it possible to predict postoperative complications. Materials and methods: The protocols of autopsies of 20 deceased were studied (10 men, mean age 64.7 years, 10 women, mean age 76.9 years). In 85 %, progressive stenosing atherosclerosis of the mouth of the left coronary artery (CA) and the anterior interventricular branch was noted. Taking into account the development of complications after stenting, three chronological groups were identified: 1) up to 3 days; 2) 37 days; 3) 715 days. The computer program ImageJ (US National Institutes of Health, USA) was used for CA morphometry. Statistical processing of the obtained results was carried out on a personal computer using the statistical tools of the Statistica 10 program. Result : It was shown that during the first 3 days after stenting of coronary arteries, acute damage to endothelial cells in the form of desquamation, dystrophic and necrobiotic processes, intramural hemorrhages in the areas of atheromas localization are observed in their walls. After 37 days and later, 715 days after stenting of the coronary artery, parietal mixed (fibrin-leukocytic), fibrin thrombi with signs of organization are observed in the lumens of the coronary artery, which is combined with the phenomena of neoangiogenesis of the artery wall. Conclusions: Damage to endothelial cells and related disturbances in the rheological properties of blood due to the expression of von Willebrand factor can initiate endothelial dysfunction with the development of thrombosis, thromboembolism of small coronary branches, which can cause myocardial perfusion disorders with the development of acute infarction.
Morphofunctional characteristics of working cardiomyocytes in offspring of mothers with experimental type 1 diabetes in the early neonatal period
Authors: Zavyalov Sergey N. , Bryukhin Gennady V.
Published: July 2023

The aim of this research was to analyze the features of morphofunctional state of left ventricular contractile cardiomyocytes of the offspring of mothers with experimental type 1 diabetes mellitus during the neonatal period. Diabetes mellitus was modeled in sexually mature female rats using streptozotocin. Specific area of myocardial stroma and parenchyma, the number of cardiomyocytes, nuclear-cytoplasmic ratio, the content of binucleated cells, as well as the content of glycogen in cardiomyocytes were determined on serial histological sections. It has been established that in the experimental rats there is a decrease in the number of cardiac muscle tissue, an increase in the cytoplasmic area of cardiomyocytes and excessive accumulation of glycogen in them. At the same time, the content of bicore cardiomyocytes significantly decreases in comparison with the control group. The results obtained allow us to conclude that experimental maternal type 1 diabetes mellitus has a negative effect on the morphofunctional formation of the contractile apparatus of the offspring heart.
Clinical application of ozone therapy, ultrasound and cryotherapy in the treatment of infected and purulent wounds on the background of chronic venous insufficiency
Authors: Karapetyan Georgy E. , Pakhomova Regina A. , Kochetova Lyudmila V. , Petrushko Stanislav I.
Published: July 2023

Research objective: To think up and estimate efficiency of the combined ozonoterapiya at treatment it is long not healing and purulent wounds which have developed against the background of chronic venous insufficiency. Materials and methods: Clinical trial has included 134 patients with chronic venous insufficiency with are long not healing purulent wounds. In a zavisismost from the chosen treatment method patients are divided into three groups. Groups were comparable on a sex, age and weight of defeat of soft fabrics. Assessment of efficiency of treatment was carried out by results of planimetry of wounds, an acid-base condition of a wound and speed of a blood-groove on border of healthy fabric and a wound. Results: On the basis of the conducted researches have proved efficiency of the combined treatment with use of a system and local ozonoterapiya, cryogenic stimulation and ultrasound. The developed algorithm of maintaining patients with chronic venous insufficiency with it is long nekhazhivayushchy wounds, reduces a painful interval to (3,1 0,6) days, accelerates filling of wounds with granulations and emergence of a regional epitalization which appeared to (6,2 1,1) days. The developed technique of a complex ozonoterapiya normalizes blood-groove speed on border of healthy fabric and a wound and restores acid-base balance. Use of a new medical complex reduces stay of patients in a hospital by 17,4 % and reduces disability terms by 12,8 %. Conclusion: At patients with the chronic venous insufficiency complicated it is long not healing infected wounds, use of the new technologies including a local and system ozonoterapiya, cryotherapy and ultrasound is expedient.
Comprehensive obstetric injury prevention based on the biological feedback method
Authors: Laipanova Halimat M. , Miroshnikov Anatoly E. , Shatilova Yulia A. , Zharkin Nikolay A.
Published: July 2023

Perineum injury is an important problem in obstetrics and causes dysfunction of the pelvic floor and prolapse female genital organs. The aim of the work is to reduce the incidence of obstetric injuries by integrated improved method of preparation for childbirth with biological feedback. Materials and research methods: Simple comparative controlled study case control was done in 175 pregnant women in two parallel groups. The main group consisted of 103 patients, trained to control the perineum muscle tone by innovative methodology. The comparison group is made up of 72 pregnant women who have passed standard preparation of a maternity school in a maternity clinic. Results: It was revealed that the perineal muscle tone correlated with high personal and reactive anxiety, which can cause birth injuries. The proposed method reduces the frequency and severity of perineum injuries (15.1 % versus 39.8 %) (OP = 2.6 95 % CI 1.5; 4.5). This makes it possible to recommend to include such method in the mothers school program.
Heart rate variability at different emotional intelligence in healthcare workers of PCR laboratories
Authors: Shkarin Vladimir V. , Orlov Dmitry V. , Kudrin Rodion A. , Robertus Alexandra I.
Published: July 2023

The ongoing pandemic caused by a new coronavirus infection (SARS-CoV-2) continues to place increased demands on the activities of clinical diagnostic laboratories. Medical personnel involved in this work often experience significant physical and emotional overload associated with being in the "red zone". This study aimed to analyze the state of heart rate variability in medical workers of PCR laboratories with different emotional intelligence when working in the conditions of the COVID-19 pandemic.
Determination of the frequency of occurrence of functional disorders of the dental system in patients with different psycho-emotional status
Authors: Elkanov Akhmat A. , Shavlakova Daria V. , Kokayan Liana V.
Published: July 2023

Dysfunctions of the temporomandibular joint have long been the subject of discussions among dentists. Many researchers identify a close relationship between the development of dysfunction of the temporomandibular joint and the psychological factor that causes hypertonicity of the masticatory muscles and a pronounced pain symptom. The purpose of this article was to determine the frequency of occurrence of functional disorders of the temporomandibular joint in patients with different psycho-emotional status. Materials and methods: In this work, the primary diagnosis of 237 patients aged 20 to 29 years was carried out. A survey and clinical examination of the examined patients was conducted for the presence of anomalies and deformities of the dental system, pathological erasability of hard tissues of teeth, bruxism, musculoskeletal dysfunctions. Functional disorders of the temporomandibular joint were assessed using the Hamburg test. The psychoemotional status of patients was assessed using the clinical questionnaire of neurotic states by K.K. Yakhin, D.M. Mendelevich. Results: Among the examined patients, temporomandibular joint dysfunction in patients with anxiety and depression was much more common than in patients with stable psychological status, (28.3 2.9) and (4.2 1.3) % respectively. A statistically significant relationship between the development of temporomandibular joint pathologies and the psychoemotional status of the patient was revealed. Conclusion: Thus, anxiety and depressive states should be taken into account as a risk factor for the development of functional disorders of the temporomandibular joint.
Ultrasound examination of the anatomy of the masticatory muscles in their hypertonicity
Authors: Makedonova Julia A. , Venskel Elena V. , Osyko Anna N. , Alexandrov Alexander V. , Pavlova–Adamovich Anastasia G. , Venskel Igor V.
Published: July 2023

Knowledge of the anatomy of the masticatory muscles is extremely important for understanding para functional muscle disorders. This article describes the anatomy of the masticatory and temporal muscles proper in their hypertonicity from the position of ultrasound examination. With the help of qualitative and quantitative indicators, the structure of the masticatory and temporal muscles proper was studied at rest and under stress. Ultrasound examination revealed point and linear hyperechoic inclusions, trigger points, which made it possible to verify muscle hypertonus.
Epidemiology of benign tumors and pseudo tumoral lesions of the femur based on an analysis of patients receiving orthopedic care
Authors: Dianov Sergey V. , Magomedov Kurash R. , Alimagomedov Shamil M. , Avdeev Alexander I.
Published: July 2023

Benign tumors and pseudo tumoral lesions of the bones belong to the largest group ofan abnormal growth of tissue in bone, which is characterized by many specific clinical, radiological and histological features. The study of data on the spread of pathology, localization, frequency of recurrence depending on gender and age characteristics helps to determine the category of people who need a more detailed examination. Aim: Determination of the incidence of an abnormal growth of tissue in bone, the most typical localization, as well as the likelihood of recurrence and malignancy in patients with benign abnormal growth of tissue in the femoral bone. Materials and methods: Materials obtained during the analysis of casesur, as well as radiographs of 465 patients operated in the Department of Traumatology and Orthopedics of the Astrakhan State Medical University from 2 years old to 70 years, from 1977 to 2018, using nonparametric analysis methods. Differences were considered significant at r 0.05. Results: Studying various tumors depending on age, it was found that the median age of patients with aneurysmal bone cyst (13.5) was significantly lower than the median age of patients with giant cell tumor (osteoclastoma) (25), respectively. When comparing persons suffering from a metaphyseal fibrous defect (non-ossifying fibroma) and a chondroma (enchondroma), a difference was noted in the average age values, which amounted to 13.5 years and 45 years, respectively. A significant difference was also found between those with a solitary bone cyst and chondroma (enchondroma), where average was 45 years. When analyzing the significance of differences in the incidence of tumors of certain localizations depending on the patients gender, it was found that the differences are not significantly significant in any of the compared groups. A certain dependence of the tumor localization on gender is not determined, which indicates that the localization of the tumor is not related to the sex of the patient. The frequency of recurrence of an abnormal growth of tissue in femoral bone is also not related to gender. Conclusions: The primary incidence of femorals tumor is predominantly characteristic of patients aged 15 years. In the groups of patients with aneurysmal bone cyst, osteochondroma (bone and cartilage exostosis) and solitary bone cyst, the median age of a person is the smallest. In the comparison of patients with giant cell tumor (osteoclastoma), metaphyseal-fibrous defect (non-ossifying fibroma), osteoid osteoma, chondroma (enchondroma), female patients predominated, and in patients with osteochondroma (osteocartilaginous exostosis) and osteoma, male patients predominated. The incidence of recurrence in the compared groups with a diagnosis of aneurysmal bone cyst, giant cell tumor (osteoclastoma), fibrous dysplasia and chondroma (enchondroma) was significantly higher than in other groups.
Prevalence and structure of refractive error among schoolchildren in Krasnoyarsk
Authors: Kochetova Tat’yana F. , Ilyukhin Danil D. , Kozlov Vasilii V.
Published: July 2023

Every year the number of patients with pathology of the visual organ increases. Refractive errors in ophthalmology occupy a leading position. Schoolchildren and preschool children are among the most vulnerable categories for the development of myopia. Material and methods: 1 165 children currently studying in schools of the Krasnoyarsk Territory were examined, a retrospective analysis of 1 335 forms of 026/from students of the same schools in 20102011 was performed. Standard methods of ophthalmological examination were used. The results of a comparative analysis of a retrospective sample of 026/y forms for 20102011 and a prospective analysis of the results of a survey of schoolchildren performed in 20212022 revealed a statistically significant increase in the number of schoolchildren with refractive disorders in all three age groups by 1.9 times (18.1 and 33.6 % respectively). Analysis of the rank structure of refractive disorders brought weak myopia to the first place, degrees, to the second degree hypermetropia of a weak degree and to the third place a spasm of accommodation. Conclusions: A large visual load and distance learning negatively affected the state of vision of students. Myopia and myopic astigmatism accounted for 71.4% in the structure of refractive errors detected in the examined schoolchildren.
The features of the production of interleukins-4, -8, -10 and -18 in normal third trimester pregnancy
Authors: Neklyudova Anastasia V. , Belan Eleonora B. , Andreeva Margarita V. , Kopan Svetlana V.
Published: July 2023

The serum level of ILL-4, -8, -10, -18 has been studied in 32 healthy women with uncomplicated pregnancy in comparison with nonpregnant women. It has been shown that the decreased production of ILL-4, -8, -10 and IL-8/IL-18 ratio, but increased production of IL-18 and IL-18/IL-10 ratio.