bluuebunny/crossref_metadata_2025 huggingface dataset:
Presentación del proyecto de difusión y divulgación “I-Filos” en Coloquio: “Innovación y medios alternativos para la filosofía en el siglo XXI realizado en la Facultad de Humanidades UAEM Toluca”
Authors: González Francisco
Published: December 2022

A partir de la recabación de testimonios profesionales y de pregrado, se describe la elaboración de un proyecto de divulgación de la filosofía en la Universidad Autónoma del Estado de México, se exponen diferentes enfoques que parten de las necesidades académicas, escolares y se extiende a la oralidad vivencial, virtual y de interconexión en diferentes plataformas tecnológicas que cubren diversos segmentos de población con el propósito de divulgar a la filosofía a partir de nuevas estrategias de comunicación filosófica, así como descubrir nuevos enfoques didácticos de transmisión del conocimiento y la cultura filosófica en el centro de México.
EVALUATION OF WING STRUCTURES AT THE CONCEPTUAL STAGE OF TRANSPORT CATEGORY AIRCRAFT PROJECTS
Authors: Kretov Anatolii , Tiniakov Dmytro
Published: December 2022

The purpose of this research is to improve the approach for evaluating of new design solutions based on sensitivity analysis of takeoff mass (SFM) to initial changes in the basic project. The approach is based on the changes assessment in maximum takeoff mass of a developed project or an already existed basic variant of an aircraft with local design (project) changes, including the aerodynamic ones, that ensure the developing of a more advanced aircraft. In comparison with the existed known approaches based on the mass growth factors, which were considered constant, the proposed approach takes into account more exactly the dependence of the takeoff mass on the initial local change in mass in terms of their functional purpose, as well as the aerodynamic characteristics. This approach allows the designer to calculate more precisely the final maximum takeoff mass changes in the early (preliminary) stages of conceptual design when looking for new design solutions. On numerical examples, carried out on the examples of transport category airplanes, a significant dependence of the wing aspect ratio influence on fuel efficiency is shown. The considered approach using SFM with semi-analytical aerodynamic analysis combination is simple, reliable and convenient in the analysis and synthesis of a new project for the design process based on the base variant.
ArtPop: A Stellar Population and Image Simulation Python Package
Authors: Greco Johnny P. , Danieli Shany
Published: December 2022

We present Artificial Stellar Populations (ArtPop), an open-source Python package for synthesizing stellar populations and generating artificial images of stellar systems, populated star by star. The code is designed to be intuitive to use and as modular as possible, making it possible to use each of its functionalities independently or together. ArtPop has a wide range of scientific and pedagogical use cases, including the measurement of detection efficiencies in current and future imaging surveys, the calculation of integrated stellar population parameters, quantitative comparisons of isochrone models, and the development and validation of astronomical image-processing algorithms. In this paper, we give an overview of the ArtPop package, provide simple coding examples to demonstrate its implementation, and present results from some potential applications of the code. We provide links to the source code that created each example and figure throughout the paper. ArtPop is under active development, and we welcome bug reports, feature requests, and code contributions from the community.

https://artpop.readthedocs.io/en/latest/

https://github.com/ArtificialStellarPopulations/ArtPop/

https://artpop.readthedocs.io/en/latest/tutorials/quickstart.html

https://github.com/ArtificialStellarPopulations/artpop-paper-figures/blob/main/scripts/
A Scintillation Arc Survey of 22 Pulsars with Low to Moderate Dispersion Measures
Authors: Stinebring Dan R. , Rickett Barney J. , Minter Anthony H. , Hill Alex S. , Jussila Adam P. , Mathis Lele , McLaughlin Maura A. , Ocker Stella Koch , Ransom Scott M.
Published: December 2022

Context. By providing information about the location of scattering material along the line of sight (LoS) to pulsars, scintillation arcs are a powerful tool for exploring the distribution of ionized material in the interstellar medium (ISM). Here, we present observations that probe the ionized ISM on scales of ∼0.001–30 au. Aims. We have surveyed pulsars for scintillation arcs in a relatively unbiased sample with DM < 100 pc cm−3. We present multifrequency observations of 22 low to moderate DM pulsars. Many of the 54 observations were also observed at another frequency within a few days. Methods. For all observations, we present dynamic spectra, autocorrelation functions, and secondary spectra. We analyze these data products to obtain scintillation bandwidths, pulse broadening times, and arc curvatures. Results. We detect definite or probable scintillation arcs in 19 of the 22 pulsars and 34 of the 54 observations, showing that scintillation arcs are a prevalent phenomenon. The arcs are better defined in low DM pulsars. We show that well-defined arcs do not directly imply anisotropy of scattering. Only the presence of reverse arclets and a deep valley along the delay axis, which occurs in about 20% of the pulsars in the sample, indicates substantial anisotropy of scattering. Conclusions. The survey demonstrates substantial patchiness of the ionized ISM on both astronomical-unit-size scales transverse to the LoS and on ∼100 pc scales along it. We see little evidence for distributed scattering along most lines of sight in the survey.
Repeated Mergers of Black Hole Binaries: Implications for GW190521
Authors: Anagnostou Oliver , Trenti Michele , Melatos Andrew
Published: December 2022

The gravitational wave event GW190521 involves the merger of two black holes of ∼85 M
⊙ and ∼66 M
⊙ forming an intermediate-mass black hole (IMBH) of mass ∼142 M
⊙. Both progenitors are challenging to explain within standard stellar evolution as they are within the upper black hole mass gap. We propose a dynamical formation pathway for this IMBH based on multiple mergers in the core of a globular cluster. We identify such scenarios from analysis of a set of 58 N-body simulations using NBODY6-gpu. In one of our simulations, we observe a stellar black hole undergoing a chain of seven binary mergers within 6 Gyr, attaining a final mass of 97.8 M
⊙. We discuss the dynamical interactions that lead to the final IMBH product, as well as the evolution of the black hole population in that simulation. We explore statistically the effects of gravitational recoil on the viability of such hierarchical mergers. From the analysis of all 58 simulations we observe additional smaller chains, tentatively inferring that an IMBH formation through hierarchical mergers is expected in the lifetime of a median-mass globular cluster with probability 0.01 ≲ p ≲ 0.1 without gravitational merger recoil. Using this order-of-magnitude estimate we show that our results are broadly consistent with the rate implied by GW190521, assuming that gravitational recoil ejection of progenitors has a low probability. We discuss implications for future gravitational wave detections, emphasizing the importance of studying such formation pathways for black holes within the upper mass gap as a means to constrain such modeling.
Solar Energetic Particle Acceleration at a Spherical Shock with the Shock Normal Angle
θBn
Evolving in Space and Time
Authors: Chen Xiaohang , Giacalone Joe , Guo Fan
Published: December 2022

We present a 2D kinematic model to study the acceleration of solar energetic particles (SEPs) at a shock driven by a coronal mass ejection. The shock is assumed to be spherical about an origin that is offset from the center of the Sun. This leads to a spatial and temporal evolution of the angle between the magnetic field and the shock-normal direction (θ

Bn
) as it propagates through the Parker spiral magnetic field from the lower corona to 1 au. We find that the high-energy SEP intensity varies significantly along the shock front due to the evolution of θ

Bn
. Generally, the west flank of the shock preferentially accelerates particles to high energies compared to the east flank and shock nose. This can be understood in terms of the rate of acceleration, which is higher at the west flank. Double power-law energy spectra are reproduced in our model as a consequence of the local acceleration and transport effects. These results will help us to better understand the evolution of SEP acceleration and provide new insights into large SEP events observed by multiple spacecraft, especially those close to the Sun, such as Parker Solar Probe and Solar Orbiter.
Association between the HLA-DQB1 Gene Polymorphism and Chronic Progression of Hepatitis B in Indonesia
Authors: Fatmawati Fatmawati , Nasrul Ellyza , Zubir Nasrul , Jamsari Jamsari , Nova Bastian , Janer Aulia
Published: December 2022

BACKGROUND: The progression of hepatitis B is affected by the activity of T lymphocytes. Activation of T lymphocytes requires a primary signal originating from the presentation of antigen by HLA molecules to T cell receptors. HLA-DQB1 gene polymorphisms can affect the ability of HLA to bind and present viral antigens to T cells, thus affecting T cell activation and potentially associated with the progression of chronic hepatitis B.
AIM: We aimed to investigate the polymorphisms of the HLA-DQB1 gene and its influence on chronic hepatitis B progression of chronic hepatitis B patients in Indonesia.
METHODS: This cross-sectional research studied chronic hepatitis B patients at the Internal Medicine Department, Arifin Ahmad Hospital, Pekanbaru, from January 2018 to December 2018. Subjects were grouped into three categories: (1) Inactive chronic hepatitis B, (2) active chronic hepatitis B, and (3) end stage liver disease (ESLD) which consisted of patients with liver cirrhosis and hepatocellular carcinoma. Examination of the HLA-DQB1 gene polymorphism was performed with the SSP-PCR method and sequenced to verify the PCR results. Analysis results of p < 0.05 were considered statistically significant.
RESULTS: The most common allele in patients with chronic hepatitis B was the HLA-DQB1 0301. The HLA-DQB1 0301 allele found primarily in the inactive chronic hepatitis B group. The DQB1 0501 allele found to be more abundant in patients with active chronic hepatitis B. The HLA DQB1 0502 allele only found in patients with chronic hepatitis B with ESLD.
CONCLUSIONS: The HLA-DQB1 gene polymorphism is associated with the progression of chronic hepatitis B in chronic hepatitis B patients in Indonesia.
Phenology and morphology of the invasive legume Lupinus polyphyllus along a latitudinal gradient in Europe
Authors: Ludewig Kristin , Klinger Yves P. , Donath Tobias W. , Bärmann Lukas , Eichberg Carsten , Thomsen Jacob Gadegaad , Görzen Eugen , Hansen Wiebke , Hasselquist Eliza M. , Helminger Thierry , Kaiskog Frida , Karlsson Emma , Kirchner Torsten , Knudsen Carola , Lenzewski Nikola , Lindmo Sigrid , Milberg Per , Pruchniewicz Daniel , Richter Elisabeth , Sandner Tobias M. , Sarneel Judith M. , Schmiede Ralf , Schneider Simone , Schwarz Kathrin , Tjäder Åsa , Tokarska-Guzik Barbara , Walczak Claudia , Weber Odile , Żołnierz Ludwik , Eckstein Rolf Lutz
Published: December 2022

Plant phenology, i. e. the timing of life cycle events, is related to individual fitness and species distribution ranges. Temperature is one of the most important drivers of plant phenology together with day length. The adaptation of their phenology may be important for the success of invasive plant species. The present study aims at understanding how the performance and the phenology of the invasive legume Lupinus polyphyllus vary with latitude. We sampled data across a >2000 km latitudinal gradient from Central to Northern Europe. We quantified variation in phenology of flowering and fruiting of L. polyphyllus using >1600 digital photos of inflorescences from 220 individual plants observed weekly at 22 sites. The day of the year at which different phenological phases were reached, increased 1.3–1.8 days per degree latitude, whereas the growing degree days (gdd) required for these phenological phases decreased 5–16 gdd per degree latitude. However, this difference disappeared, when the day length of each day included in the calculation of gdd was considered. The day of the year of the earliest and the latest climatic zone to reach any of the three studied phenological phases differed by 23–30 days and temperature requirements to reach these stages differed between 62 and 236 gdd. Probably, the invasion of this species will further increase in the northern part of Europe over the next decades due to climate warming. For invasive species control, our results suggest that in countries with a large latitudinal extent, the mowing date should shift by ca. one week per 500 km at sites with similar elevations.
Domestic Violence Is a Significant Public Health and a Health Administration Issue in the U.S.
Authors: Huff Allison J. , Burrell Darrell Norman , Aridi Amalisha Sabie , McGrath Grace E.
Published: December 2022

This paper discusses domestic violence as a public health concern and a health administration issue. People affected by domestic violence, such as physical, mental, sexual, and financial abuse, experience higher rates of trauma leading to PTSD. This study explored healthcare interaction with victims of domestic violence. Effective communication, proper domestic violence training, and screening should be used and implemented in healthcare settings to support victims regardless of where they may be within the abuse cycle. This paper adds to the dialogue on domestic violence by pulling together other previous research and by offering tools that can be implemented in emergency rooms, urgent care facilities, and medical practices to recommend standard processes focused on identifying dangerous situations and giving victims the support they need.
Decentralized Identity Management Using Blockchain
Authors: Singla Ashish , Gupta Nakul , Aeron Prageet , Jain Anshul , Sharma Divya , Bharadwaj Sangeeta Shah
Published: December 2022

This article explores the usage of decentralised identity (DID) management using blockchain in global organisations to support secure usage of information resources. Blockchain as technology was initially introduced as a cryptocurrency and there have been challenges in its adoption for enterprise applications such as identity management. DID is emerging as one of the strong blockchain adoption use cases. Industry pioneers and users across domains have started exploring DID use cases, which help better protect their personal data and application access control as compared to traditional, central, or federated identity management models. In this exploratory work, the authors employ qualitative secondary case-based study research methodology to understand the challenges of the current digital identity management landscape and explore the possible benefits of DID as an emerging identity management paradigm. They propose a conceptual cube framework for analysing and studying various DID platforms thereby contributing to both the theory and practice of digitally secure identity.
A Study of the Influence of Entrepreneurs' Geographic and Academic Relationships on Corporate Innovation
Authors: Ayoungman Fairtown Zhou , Pang Liyuan , Chu Yingjing
Published: December 2022

Corporate innovation is the driver and wellspring of business operation and development. Thus, how entrepreneurs can enhance the innovation capabilities of their enterprises is an important topic in corporate development. Taking A-shares companies listed on the Shenzhen and Shanghai stock exchanges as its sample, this paper investigated the influence of entrepreneurs' geographic and academic relationships on corporate innovation. This study found that after controlling for other influencing factors, entrepreneurs' geographic and academic relationships have a significant positive effect on corporate innovation. When entrepreneurs have strong ability endowment, the positive effect of their geographic and academic relationships on corporate innovation is especially sizeable. In addition, the more prestigious the entrepreneurs' university education is, the stronger the promoting effect of their academic relationships on corporate innovation.
The Value of Routine Tests before Pediatric Eye Surgery
Authors: Horikawa Hideyo , Matsuo Mitsuhiro , Yamazaki Mitsuaki
Published: December 2022

Background:

Routine tests before ophthalmologic surgery in adult patients are no longer recommended. However, there are limited data on the utility of routine preoperative tests for children.

Aims:

We aimed to describe the effect of routine preoperative tests on systemic perioperative complications by hospital discharge or by day 30 following eye surgery.

Settings and Design:

This was a single-center, observational, and descriptive study.

Subjects and Methods:

We examined all patients ≤ 17 years old for whom ophthalmologists consulted with anesthesiologists before eye surgery under general anesthesia in an academic teaching tertiary care hospital from January 2010 to December 2019.

Results:

A total of 708 pediatric patients were analyzed. The mean patient age was 8.5 ± 4.6 years. The most frequently performed procedure was strabismus surgery in 433 patients (61.2%). Following anesthetic consultations, 15 patients (2.1%) underwent surgery postponed due to abnormalities at the physical examination. Routine tests identified that the two patients (0.3%) required additional evaluations due to elevated serum creatine kinase and electrocardiographic abnormalities. However, further examinations found that these abnormalities were unremarkable. The remaining 691 patients (97.6%) underwent surgery as scheduled. Substantial intraoperative blood loss was observed only in three patients with malignant tumors or trauma. The incidence of systemic complications was 0 (0%; 95% confidence interval, 0%–0.05%).

Conclusions:

These data indicated that the development of systemic perioperative complications following pediatric ophthalmic surgery is rare. Preoperative tests should be requested only if they are clinically indicated or before potentially bleeding procedures, such as malignancy or trauma surgery.
The effect of COVID-19 vaccines on sperm parameters: a systematic review and meta-analysis
Authors: Ma Yu-Cheng , Cheng Chao , Yuan Chi , Xiang Li-Yuan , Wen Jun , Jin Xi
Published: December 2022

Published data were gathered for a meta-analysis to determine the difference in sperm parameters before and after administration of different types of coronavirus disease 2019 (COVID-19) vaccines, because the reproductive toxicity of COVID-19 vaccines has not yet been evaluated in clinical trials and COVID-19 has been associated with decreases in sperm quality. The preferred procedures for systematic reviews and meta-analyses were followed in the conduct and reporting of this study. The average sperm parameters of all sperm donors’ multiple sperm donations were compared before and after receiving various COVID-19 vaccinations. Semen volume, total sperm motility, total sperm count, morphological change, and sperm concentration were the primary outcome measures. We compiled and analyzed the results of six studies on total sperm motility, six studies on semen volume, six studies on sperm concentration, two studies on morphological change, and two studies on total sperm count. Parameter comparisons with patients who had and had not been vaccinated were only reported in one of the included studies. When different types of COVID-19 vaccine injections were compared, no discernible differences in parameters were observed. According to the available data, the parameters of semen are unaffected by inactivated or messenger RNA (mRNA) COVID-19 vaccinations. To support these findings, additional prospectively designed research is required.
Novel compound heterozygous mutations in DNAH1 cause primary infertility in Han Chinese males with multiple morphological abnormalities of the sperm flagella
Authors: Wang Meng , Yang Qi-Yu , Zhou Jue-Pu , Tan Hui-Ping , Hu Juan , Jin Lei , Zhu Li-Xia
Published: December 2022

This study aimed to identify genetic causes responsible for multiple morphological abnormalities of the sperm flagella (MMAF) in the Han Chinese population. Three primary infertile males with completely immobile sperm and MMAF were enrolled. Whole-exome sequencing and Sanger sequencing were performed to identify disease-causing genes. Subsequently, morphological and ultrastructural analyses of sperm flagella were investigated. The probable impact of genetic variants on protein function was analyzed by online bioinformatic tools and immunofluorescence assay. Three patients with dynein axonemal heavy chain 1 (DNAH1) gene compound heterozygous variations were identified. DNAH1 c.7435C>T, p.R2479X and c.10757T>C, p.F3586S were identified in the patient from Family 1, c.11726_11727delCT, p.P3909fs and c.12154delC, p.L4052fs were found in the patient from Family 2, and c.10627-3C>G and c.11726_11727delCT, p.P3909fs existed in the patient from Family 3. Four of these variations have not been reported, and all the mutations showed pathogenicity by functional effect predictions. The absence of the center pair and disorganization of the fibrous sheath were present in sperm flagella at the ultrastructural level. Moreover, the expression of DNAH1 was absent in spermatozoa from the participants, validating the pathogenicity of the variants. All three couples have undergone intracytoplasmic sperm injection (ICSI), and two couples of them became pregnant after the treatment. In conclusion, the newly identified DNAH1 mutations can expand the mutational and phenotypic spectrum of MMAF genes and provide a theoretical basis for genetic diagnosis in MMAF patients. It is recommended to conduct genetic screening in male infertility patients with MMAF and provide rational genetic counseling, and ICSI might be an optimal strategy to help with fertilization and conception for patients with DNAH1 mutations.
Clinico-epidemiological profile of genital dermatoses in people living with HIV
Authors: Dhillon Supreet Kaur , Kura Mahendra M.
Published: December 2022

Context:

The protean mucocutaneous manifestations of HIV and the resultant opportunistic infections are well documented. Genital dermatoses can be either venereal or nonvenereal in origin. As the presence of HIV infection greatly increases the chances of acquiring another sexually transmitted pathogen, these are often presumed to be venereal in origin.

Aims:

The aims of the study were to record the different morphologies of genital skin lesions in seropositive patients and to classify them as venereal or nonvenereal in origin.

Settings and Design:

This was an observational study undertaken in seropositive patients with genital skin lesions attending the outpatient department of dermatology at a tertiary health-care center.

Subjects and Methods:

One hundred and seventy-seven seropositive patients with genital lesions were enrolled. A detailed history was taken; the genital and dermatological examination was performed.

Statistical Analysis Used:

None.

Results:

Males predominated the study population with the majority (79.1%) falling into the reproductive age group of 15–49 years. Nonvenereal genital dermatoses (59%) outnumbered sexually transmitted infections (STIs) (41%) out of which the most frequently encountered were dermatophytosis, scabies, and intertrigo. Other entities recorded were inflammatory dermatoses, cutaneous adverse drug reactions, and tumors. The most common STIs were herpes genitalis (55.4%) and anogenital warts (32.5%).

Conclusion:

This study showed that nonvenereal genital dermatoses are more common than STIs in people living with HIV. Our findings reiterate the fact that genital lesions should be approached with caution as a presumptive and hasty diagnosis of STI adds greatly to the morbidity of the patient in terms of guilt and shame, and adversely affects the quality of life.
Pediculosis pubis presenting as pediculosis capitis, pediculosis corporis, and pediculosis ciliaris in a case of Alport syndrome
Authors: Dave Manal D. , Mehta Hita H. , Gorasiya Amitkumar Rameshbhai , Nimbark Devanshi Nitin
Published: December 2022

Pediculosis is an infestation of lice on the human body. Pediculosis pubis is primarily found in the pubic region and is usually transmitted by sexual contact. Diagnosis is done by visualization of mites which can be aided by the use of dermoscope. Hereby, we report a case of an Alport syndrome patient having extensive pubic lice infestation with no sexual history and probable transmission from cattle.
Prevalence of Artifacts in Cone-Beam Computed Tomography
Authors: Mahesh K. P. , Deshpande Prasannasrinivas , Viveka S
Published: December 2022

Introduction:

In dentistry, cone-beam computed tomography (CBCT) is an essential diagnostic technique. To use CBCT imaging technology efficiently, it is vital to understand its benefits and limits. Artifacts are discrepancies between the reconstructed visual image and the actual content of the subject that can reduce anatomic accuracy.

Aims and Objectives:

This study aimed to assess the prevalence of artifacts in CBCT images.

Materials and Methods:

Three hundred sixty-five CBCT images were retrospectively studied to identify artifacts, and the prevalence of different artifacts was recorded. Frequency and percentages are used for descriptive statistics. The Chi-square test was used for interventional statistics.

Results:

Artifacts were observed in two hundred forty-five images examined. The most prevalent image artifact recorded was the beam hardening artifact that falls under the physics-based category.

Conclusion:

Physics-based and scanner-based artifacts may be avoided by concentrating on X-ray parameters and scanner detector state, respectively. To limit the frequency of patient-based artifacts in CBCT images, patients should be instructed to remove any metallic jewelry and be stabilized appropriately. Scan time should be maintained to a minimum.
Syndromic Multiple Cystic Lesions
Authors: Patwegar Rahila K. , Paranjpe Arati G. , Byakodi Raghavendra S. , Kshar Avinash B.
Published: December 2022

Odontogenic cystic lesions of the jaw usually present as a single lesion and rarely occur as multiple cysts occupying more than one quadrant of the jaw. Multiple cysts are usually a part of a syndrome. Cystic lesions of the jaw are rarely symptomatic in pediatric age and, thus, very difficult to identify at an early age. Here, we present a case of multiple cysts in a pediatric patient and a review.
A Diagnostic Challenge of Growth on the Tongue in Geriatric Patient—A Rare Case Report
Authors: Sadaksharam Jayachandran , Kathiresan Iswarya , Vimal Sophia Jeba Priya , Palanisamy Anitha
Published: December 2022

Verruciform xanthoma (VX) is an uncommon benign inflammatory mucocutaneous condition of uncertain etiopathology which occurs on the oral mucosa. Histologically, VX is distinguished from other lesions by the presence of large numbers of foam cells in connective tissue papillae. The treatment of the VX one involves local surgical excision, and recurrence is rare. An 82-year-old male patient presented with a painless growth in the tongue for the past year. On clinical examination, a white exophytic lesion was found on the right lateral border of the tongue, and a solitary cauliflower-like growth was seen on the left ventral surface of the tongue, which was painless on palpation. That was provisionally diagnosed as squamous papilloma on the left side and verrucous carcinoma on the right side. This case report describes an unusual case of two different lesions present in the tongue that have features of VX and squamous cell carcinoma.
Correlation of a New Binary System in Grading of Oral Leukoplakia for Its Prediction of Malignant Transformation - A Retrospective Record-Based Study
Authors: Sangamesh N. C. , Suresan Vinay , Vidya K. C. , Singh Dhirendra K.
Published: December 2022

Introduction:

Oral Leukoplakia is a premalignant lesion with an increased risk of developing oral cancer when the lesion is non-homogeneous. There is a need to validate clinical presentations of a commonly occurring Leukoplakia lesion and its probability of dysplastic changes over some time.

Aim:

To correlate the Diagnostic accuracy of clinical lesion diagnosed as Leukoplakia and the presence or absence of dysplasia through its histopathological correlation.

Materials and Methods:

This study gathered data retrospectively during 2016–2021 with an initial diagnosis of oral Leukoplakia. A set of 611 slides were included in the study that was signed out as oral Leukoplakia. We tested the hypothesis that a binary grading system categorizes lesions as “presence” or “absence” of oral epithelial dysplasia. A logistic regression analysis was used in predicting the presence of dysplasia among the various clinical criteria.

Results:

Most of the mild dysplasia was reported in the buccal mucosa (n = 195; 31.91%), followed by 6 (0.98%) cases in the vestibule. A mean age of 32.33 ± 7.0 was observed for severe dysplasia. A statistically significant relationship between the risk estimates for the clinical diagnosis and dysplasia was noted for all the lesion types.

Conclusion:

The study concludes that the clinical presentation of a lesion can predict the underlying dysplastic changes, and mixed red and white lesions with growth possess the highest risk of malignant transformations.
Evaluation of the efficacy of BIG score and injury severity score in the prediction of mortality in pediatric blunt polytrauma
Authors: Arafa Mohamed A. , Elheniedy Mohamed A. , Elafifi Mahmoud , Taha Waleed M.
Published: December 2022

Background

Pediatric polytrauma is the first cause of death in childhood, representing more than all other causes of death combined; it also represents the leading cause of permanent disability in this population.

Aim

Our aim was to discover the effectiveness of BIG score (abbreviation taken of the first letter of Base deficit, International normalized ratio, and Glasgow coma scale) injury severity score (ISS) in children less than 16 years presenting with blunt polytrauma as an early predictor for mortality in the Emergency Department, Tanta University Hospital.

Patients and methods

A prospective study was conducted on 105 cases of less than 16 years with blunt polytrauma of both sexes, who were admitted to the Emergency and Traumatology Department in Tanta University Hospitals, in the period from March 2019 till March 2020.

Results

BIG score was superior to ISS in the prediction of mortality and superior also to Glasgow coma scale, international normalized ratio, or base deficit alone. Taking the cutoff more than or equal to 18 of BIG score to predict mortality has a sensitivity of 97.62%, specificity of 85.71, and a cutoff more than or equal to 21 of ISS to predict mortality has a sensitivity of 75% and a specificity of 80.95%.

Conclusion

Pediatric BIG score is an easily applicable method for predicting mortality in the pediatric emergency and is superior to ISS in the prediction of mortality. This may represent a guide in the evaluation of early invasive and noninvasive monitoring and treatment plans in the ICU.
Evaluation of C-reactive protein and platelet–lymphocyte ratio as potential tumor markers in Egyptian patients with hepatocellular carcinoma
Authors: Abd Elkawy Nada F. , Elkhouly Reham Abd E. , Mabrouk Maaly M. , El Kassas Galal El Din M.
Published: December 2022

Background

Hepatocellular carcinoma (HCC) is the most frequent type of liver malignancy. For HCCs with low or normal alpha-fetoprotein (AFP), several indicators have been proposed.

Aim

To evaluate C-reactive protein (CRP) and platelet–lymphocyte ratio (PLR) as potential HCC markers.

Patients and methods

This was a cross-sectional study carried out at the Tropical Medicine Department of Tanta University. A total of 90 patients with cirrhosis owing to chronic hepatitis C were divided into group 1, which included 30 patients with HCC with low AFP; group 2, which included 30 patients with HCC with elevated AFP (>20 ng/ml); and group 3, which included 30 patients with liver cirrhosis (as control group). The PLR, CRP, and AFP were measured in each group.

Results

There were significant differences among the studied groups regarding CRP and AFP, with highest levels in group 2 and then group 1 and the least level in group 3. PLR showed significantly higher levels in group 3 when compared with group 2 and group 1.

Conclusion

CRP can differentiate patients with HCC in total and patients with HCC with low AFP from patients with cirrhosiswith high sensitivity and moderate specificity. When PLR is combined with CRP, the specificity is increased for the diagnosis of HCC cases from patients with cirrhosis.
Upaya Perwujudan Moderasi Beragama Di Kalangan Siswa Melalui Buku Teks
Authors: Musyrifin Ilmi Mu'min , Fawwaz Muhammad Faiz Andeaz , Maesaroh Indah , Jubba Hasse
Published: December 2022

Perwujudan moderasi beragama di Indonesia merupakan salah satu hal yang penting untuk banyak pihak. Tidak hanya terbatas pada golongan dewasa, upaya untuk menanamkan nilai persatuan dan kebersamaan di atas perbedaan juga dilakukan pada anak-anak muda. Disamping untuk mempersiapkan generasi selanjutnya untuk mengisi Indonesia, angka intoleransi diantara pemuda tingkat pertama di Indonesia tergolong cukup tinggi. Oleh sebab itu, tujuan penelitian ini untuk menganalisis upaya perwujudan membangun sikap moderasi beragama di kalangan pemuda Indonesia melalui buku teks yang dilihat dari empat indikator moderasi beragama menurut Kementerian Agama RI. Penelitian ini menggunakan model studi pustaka dengan menggunakan sumber utama penelitian buku teks Pendidikan Agama Islam jenjang Sekolah Menengah Pertama kelas 7, 8, dan 9.  Hasilnya adalah bahwa empat indikator moderasi beragama menurut Kementerian Agama RI yakni komitmen, toleransi, anti kekerasan, dan akomodatif terhadap budaya lokal belum secara keseluruhan termuat dalam setiap buku teks. Dengan demikian, disarankan untuk melakukan pembaruan materi terkait moderasi beragama supaya memuat pembahasan secara menyeluruh semua indikator tersebut. Selain melalui buku teks, guru juga menyampaikan moderasi beragama dengan berbagai macam model pembelajaran dengan menyesuaikan bahan ajar pada buku teks. Model-model pembelajaran yang ada diantaranya adalah problem based learning, project based learning dan contextual learning. Tulisan ini masih terbatas pembahasannya terkait upaya perwujudan moderasi beragama hanya dinilai dari empat indikator moderasi beragama menurut Kementerian Agama RI saja. Oleh karena itu, tulisan ini menyarankan untuk melakukan berbagai kajian yang lebih luas dengan menambahkan sumber buku yang dianalisa guna memberikan perwujudan generasi muda di Indonesia yang moderat.

Kata Kunci: Moderasi Beragama, Siswa, Buku Teks
ALTERNATIVNI INVESTICIONI FONDOVI U EU I OSVRT NA STANjE U REPUBLICI SRBIJI
Authors:   University of Kragujevac, Faculty of Law, Labudovic Stankovic Jasmina
Published: December 2022

Alternative investment funds belong to the category of institutional investors who base their activities on very risky investment strategies. They operate all over the world, especially in the so-called offshore countries due to more favorable tax treatment. In the first part of this paper, the author presents these funds in the EU, as well as the risks they can cause. In the second part of the paper, the author talks about alternative investment funds in Serbia. The adoption of the Law on Alternative Investment Funds in 2019 created conditions for the establishment and operation of these funds. The reasons for passing the law are primarily political, but also the need to attract investors and encourage the development of the domestic capital market.
El ciclo reproductivo de la oveja
Authors: Aguado Paola Isaira Correa , Vidauri Zimri Cortés , Flores Carlos Fernando Aréchiga , Delgado Romana Melba Rincón , Miramontes Claudia Elisa Valdez , Carlos Marco Antonio López , Haro Ignacio Mejía
Published: December 2022

La hormona melatonina regula el ciclo reproductivo de la oveja, para que los partos ocurran en primavera y verano, por ser la temporada del año más favorable para la supervivencia de los corderos recién nacidos.  La melatonina se produce en la glándula pineal durante las horas de obscuridad del día y ejerce su acción sobre la pars tuberalis (PT) de la hipófisis.  El fotoperiodo bajo del otoño e invierno (i.e., pocas horas luz por día) y una mayor secreción de melatonina estimulan al eje hipotalámico-hipofisiario-gonadal (H-H-G) para iniciar la actividad ovárica, comenzar la ciclicidad estral y garantizar la concepción en las ovejas.  Generalmente, la gestación se logra durante el otoño e invierno y los partos se presentan durante la primavera.  Es decir, las ovejas estarían lactando durante primavera y verano.  El anestro de las ovejas se presenta durante los días con mayor número de horas luz por día (primavera-verano).  La hormona prolactina (PRL), se secreta durante la lactancia y su producción se incrementa durante los días con mayor cantidad de horas luz por día.  Por lo tanto, la secreción de prolactina se comporta de manera inversa a la producción de melatonina. En los días con mayor cantidad de horas luz se reduce la secreción de melatonina en la pars tuberalis (anestro), y se promueve la síntesis de la isoforma del factor de crecimiento vascular endotelial (VEGF) relacionado con la angiogénesis.   Aunado a ello, se incrementa la sintesis de taquicininas, sustancia P y neuroquinina A en la pars tuberalis y se estimula la síntesis de prolactina en la pars distalis (PD) de la hipófisis.  Al disminuir la melatonina, se incrementa la expresión del factor de transcripción Eya3, el cual a través de la secreción de tirotropina (TSH) reduce la liberación episódica de GnRH y probablemente se relacione con el establecimiento de la retroalimentación negativa del estradiol sobre el hipotálamo para reducir la secreción de GnRH, efecto estimulado por la dopamina. El VGFA también inhibe la expresión del gen FSH, con lo que se inactiva al eje H-H-G.  La prolactina, junto con la dopamina, reducen el efecto de la GnRH sobre la secreción de ambas gonadotropinas: hormona folículo-estimulante (FSH) y hormona luteinizante (LH), por parte de la adenohipófisis.
Drug Eruptions: A Challenge for Dermatologists and First Contact Physicians
Authors:   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México, Madrid María Jimena Talamante , Espejo Nuño Renata Monserrat ,   Universidad Autónoma de Guadalajara. Guadalajara, Jalisco, México., Gómez Alfredo López ,   Benemérita Universidad Autónoma de Puebla. Puebla de Zaragoza, México., Pérez Nayeli González ,   Universidad de Guadalajara. Guadalajara, Jalisco, México., Manzanera María Isabel Saad ,   Universidad Autónoma de Chihuahua. Chihuahua, México.
Published: December 2022

Adverse drug reactions are quite frequent in current medical practice, being the skin manifestations the most commonly observed, and although they generally have a benign and self-limiting evolution, but in exceptional cases they can be serious and even fatal. The priority in the evaluation of toxicoderma is established in the identification and distinction of severe skin adverse reactions, the so-called SCAR, among which include Stevens Johnson syndrome (SJS), toxic epidermal necrolysis (TEN) and drug-induced hypersensitivity syndrome/drug reaction with the presence of eosinophilia and systemic symptoms (DISH-DRESS), to which should be added acute generalized exanthematous pustulosis (AGEP). Unfortunately, however, our current knowledge does not allow us to determine the true incidence of these reactions, to establish the diagnosis and its causal relationship with certainty, or even to be able to anticipate its appearance.
Investment Performance of Life Insurance Companies in Indonesia
Authors:   Department of Accounting, Bakrie University, Jakarta, Indonesia, Weni Pratiwi Monica
Published: December 2022

This study aims to examine the effect of volume of capital on investment performance moderated by leverage in life insurance companies in Indonesia. This topic was investigated because of the phenomena and differences in results regarding the low investment performance of several life insurance companies in Indonesia. The population of this study is established life insurance companies registered with the Financial Services Authority during the 2017-2021 period with a total sample of 116 taken using the purposive sampling method. The data analysis method used is moderate regression analysis with the results showing that the volume of capital does not affect investment performance, but after the volume of capital is moderated with leverage, it can affect investment performance.
Stock Market Reaction of Pharmaceutical Sector Companies to the Announcement of the Covid 19 Endemic in Indonesia
Authors:   Department of Accounting, Bakrie University, Jakarta, Indonesia, Weni Pratiwi Monica
Published: December 2022

The transition period from the pandemic to the endemic covid 19 in Indonesia had an impact on increasing the Jakarta Composite Index on the Indonesia Stock Exchange, however, the stock prices of pharmaceutical sector companies decreased one day after the endemic announcement date. Based on this phenomenon, this study aims to analyze market reactions that cause abnormal returns in pharmaceutical sector companies listed on the Indonesia Stock Exchange. The population used in this study were pharmaceutical sector companies listed on the Indonesia Stock Exchange with a total sample size of 110. The data analysis method used was a descriptive analysis approach. The results of this study indicate that there is an increase in abnormal returns during the transition from the pandemic to the endemic Covid-19 in pharmaceutical sector companies in Indonesia.
Studi Literatur Peran Bank Indonesia Terhadap Stabilitas Keuangan
Authors: Pratiwi Radila , Daulay Wan Akbar Arramadhan , Chairina Chairina
Published: December 2022

Bank Indonesia's primary responsibility in monetary, banking and payment systems is to ensure monetary and financial system stability. Without financial system stability, Bank Indonesia's success in maintaining monetary stability will not be significant. support long-term economic growth. The forces associated with money and monetary soundness resemble different sides of a coin that cannot be separated. Financial stability is the foundation upon which the efficacy of monetary policy is built, and the converse is that monetary policy has a significant impact on financial stability. Because the financial system is one of the monetary policy transmission channels, monetary policy transmission cannot function normally if financial system instability occurs. Conversely, financial system stability will be fundamentally affected by monetary instability due to ineffective financial system operations. Therefore, maintaining financial system stability remains the duty and responsibility of Bank Indonesia.
Funérailles māori et « identification » du statut des ancêtres en Nouvelle-Zélande Aotearoa aux XXe et XXIe siècles. Usages et fonctions des manteaux prestigieux māori (kākahu) en contexte funéraire
Authors: RENARD Lisa
Published: December 2022

Résumé

Chez les Māori de Nouvelle-Zélande Aotearoa, les funérailles (tangihanga) sont les cérémonies les plus importantes de la vie sociale. Elles permettent aux vivants d’entretenir des relations entre eux et avec leurs ancêtres, en vue d’assurer leur vie, celle du collectif et sa reproduction. Les Māori doivent ainsi pouvoir « identifier » les entités avec lesquelles ils souhaitent entrer en relation dans le respect de l’ordre de préséance qui organise l’espace sociocosmique māori. Pour y parvenir, ils peuvent s’appuyer sur des entités hautement valorisées apparentées à des « trésors ancestraux » tangibles et intangibles transmis de génération en génération, qu’ils nomment taonga. Parmi ceux-ci, « l’art des généalogies » (whakapapa) et les « manteaux prestigieux māori » (kākahu) sont particulièrement mobilisés au cours du cycle des cérémonies funéraires qui facilitent le passage d’une personne du monde des vivants à celui des morts.

Abstract

Title: Māori funerals and the « identification » of the status of ancestors in New Zealand Aotearoa in the 20th and 21st centuries. The uses of functions of māori cloaks (kākahu) during funeral ceremonies

Among the Māori of New Zealand Aotearoa, funerals (tangihanga) are the most prominent ceremonies in social life. They allow the living to maintain relationships with each other and with their ancestors. These relationships are meant to ensure on the one hand their life and on the other hand the life of the community and its reproduction. Therefore, the Māori must be able to "identify" the entities they wish to connect with while respecting the order of precedence that organizes the Māori sociocosmic space. To achieve this, they can rely on highly valued entities called taonga. The taonga are tangible and intangible ancestral treasures handed down from generation to generation. Among these, the art of genealogies (whakapapa) and māori cloaks (kākahu) are particularly useful during the cycle of funeral ceremonies which enables the passage of a person from the world of the living to the world of the dead.
Case Report - Effects of Specialized Supplementation in the Healing Process for the Prevention/Treatment of Radiodermatitis
Authors:   Fundação Antônio Prudente - AC Camargo Cancer Center, Brazil, Miola Thais Manfrinato , Campos Rafaela de Araujo ,   Nestlé Health Science, São Paulo, Brazil
Published: December 2022

Background: Breast cancer is the most common cancer among women worldwide. This case report aimed to evaluate the effect of specialized oral nutritional supplements (ONS) in the prevention and treatment of radiodermatitis in patients undergoing radiotherapy (RT) for breast cancer. Methods: Case report of three patients during radiotherapy treatment, one using specialized supplementation with a preventive objective and another to treat radiodermatitis, the third patient did not use any supplement, being the control. Results: Patients who used ONS showed beneficial results regarding the appearance of radiodermatitis and evolution of its degree when compared to the control patient. Patient 1 had radiodermatitis only at the end of RT with grade I toxicity. Patient 2 had radiodermatitis in the middle of treatment, where ONS started, with grade I toxicity and the lesion did not progress until the end of treatment. On the other hand, patient 3 had grade I radiodermatitis in the 10th session, evolving to grade II in the 23rd session. Conclusions: It was concluded that the use of specialized ONS helps in the healing process of radiodermatitis in patients undergoing RT in the breast region, in addition to maintaining/improving body composition.
Nuevas demandas asociadas a las enfermedades cardiovasculares en Brasil por la pandemia COVID-19
Authors: Teixeira Martins Marcos Vinicius
Published: December 2022

Desde el inicio de la propagación de la enfermedad se han descrito varios tipos de complicaciones cardiovasculares derivadas de la COVID-19. Sin embargo, en Brasil, el manejo adecuado de las complicaciones cardiovasculares no está ocurriendo en todos los casos debido a la significativa reducción de la demanda de servicios de salud durante el período pandémico.