bluuebunny/crossref_metadata_2025 huggingface dataset:
$\mu$-Caputo type time-delay Langevin equations with two general fractional orders
Authors: AYDIN MUSTAFA , Mahmudov Nazim
Published: March 2022

{In the present paper, a $\mu$-delayed Mittag-Leffler
type function is introduced as a fundamental function. By means of
$\mu$-delayed Mittag-Leffler type function, an exact
analytical solution formula to non-homogeneous linear delayed Langevin
equations involving two distinct $\mu$-Caputo type
fractional derivatives of general orders is given. Also, a global
solution of nonlinear version of delayed Langevin equations is inferred
from the findings on hand and is verified with the aid of the
functional(substitutional) operator. In terms of exponential function,
we estimate $\mu$-delayed Mittag-Leffler type function.
Existence uniqueness of solutions to nonlinear delayed Langevin
fractional differential equations are obtained with regard to the
weighted norm defined in accordance with exponential function. The
notion of stability analysis in the sense of solutions to the described
Langevin equations is discussed on the grounds of the fixed point
approach. Numerical and simulated examples are shared to exemplify the
theoretical findings. This paper provides novel results.
Characterisation of Clinical Mastitis Occurring in a Dairy Herd of Holstein Friesian Cows
Authors: Constantin Găvan
Published: March 2022

The objective of the present study were to characterize clinical mastitis (CM) occurring in a dairy herd of Holstein Friesian cows located at Agricultural Research and Development Station (ARDS) Simnic-Craiova, Romania (182 m above sea level, 4°19’N and 23°48’E). The severity of CM was classified as grade 1 – when only the milk was abnormal, grade 2 – when abnormal milk was accompanied by swelling or redness of mammary gland and grade 3 – when the cow exhibited systemic signs of illness such as depression, anorexia, dehydration or fever. Only grade 1 and grade 2 of clinical mastitis were analysed in this study. Duplicate quarter milk samples from affected quarters when collected before treatment (Pre-treatment). After the collection, cows were treated using the form protocol. A second set of duplicate quarter milk sample were collected from enrolled quarters at 14 to 21 days after the end of treatment (Post-treatment). Cow level follow-up data was collected for 90 days after the enrolment. Microbiological diagnosis at enrolment included gram-negative, gram-positive and no growth. Data was collected between December 2016 and November 2020, of the 58 cases of CM only 52 cases of grade 1 (n=35) and grade 2 (n=17) were used in analysis. Six cases of CM were of grade 3 (not used in this study). Most causes of CM included in this study were caused by Gram-negative pathogens followed by gram positive pathogens. The common pathogens were E. coli, environmental streptococci Enterobacter spp. and coagulase-negative streptococci. Treatment cure was greater for Gram- negative pathogens. Identification of pathogens causing CM or severity is important in strategic treatment decisions.
Työpajanuoret tiedonhakijoina – digitaalisen osaamisen kasautuvuus
Authors: Saikkonen Loretta
Published: March 2022

Tutkimuksessa selvitetään suomalaisten työpajanuorten (N=93) tiedonhakutaitoja. Aineisto on kerätty digitaalista osaamista mittaavan testin avulla. Pelkän peruskoulun tai ammatillisen koulutuksen suorittaneet onnistuivat tehtävissä lukion käyneitä heikommin. Sukupuolen tai ikäryhmän mukaan ei todettu tilastollisesti merkitseviä eroja. Suurin osa työpajanuorista osasi muodostaa yksinkertaisen hakulausekkeen. Hakuoperaattorituntemus oli heikompaa. Hakutulosten luotettavuuden osasi arvioida yli puolet ja relevanssin noin kolmannes nuorista. Korrelaation mukaan ainoat muuttujat, jotka olivat tilastollisesti merkitsevästi yhteydessä tiedonhakutaitoihin, olivat taidot muilla digitaitojen osa-alueilla. Sen sijaan erilaiset digitaalisen teknologian käyttötavat eivät olleet yhteydessä tiedonhakutaitoihin, mutta korreloivat toistensa kanssa. Regressioanalyysin mukaan tärkeimmiksi tiedonhakutaitojen ennustajiksi nousivat digitaaliset viestintätaidot ja tiedonhallintataidot. Informaatio-, viestintä- ja tiedonhallintataidot karttuvat tämän tutkimuksen mukaan parhaiten, kun niitä vahvistetaan rinnakkain. Näitä taitoja voitaisiinkin vahvistaa osana nuorten työpajatoimintaa.
Clinical Appearance of Lateral Incisive Canal
Authors: Nagorniak Ivan
Published: March 2022

A 59-year-old patient was referred to dental clinic for immediate dental implantation in the area of upper central incisors due to severe periapical lesions which not subjected to endodontic retreatment and periapical surgery. Removal of central incisors and periapical lesions, dental implant placement were performed under local anesthesia with sedation. During the surgery a significant bleeding was noted from a unilateral accessory canal (asterisk). In our case, it exited at the palatal aspect of tooth 2.1; its foramen was of oval shape and measured 2.00 × 3.00 mm. In case of that canal`s location it terms lateral incisive canal. Other similar terms can also be applied to describe this rare anatomical structure: accessory canal of the anterior maxilla, lateral incisor canal, and neurovascular variation in anterior palate. Panel clearly demonstrates the axial intraoperative view after bone drilling (circle) (preparing a hole for second implant); implant analog (which is used for correct positioning of implant) inserted into socket of tooth 1.1 is indicated by triangle. Lateral incisors marked by numbers 1.2 and 2.2.
Financial Inclusion and Economic Development in Africa
Authors: Winful Ernest C. , Opoku-Asante K. , Mensah Mathew O. , Quaye Josiah N. A.
Published: March 2022

Post-2015 Development Agenda put financial inclusion as a key objective for United Nations member countries. This objective seeks to improve people's livelihoods, reduce poverty, and advance economic development in member countries. It is asserted that there is a significant relationship between financial inclusion and economic development, which Post-2015 Development Agenda seek to achieve. To corroborate a panel data were collected from 2000 to 2017 for 41 countries in Africa. Using a GMM estimation technic, the article corroborates the reviewed literature, which asserts appositive relation. Of the three attributes (financial access, financial stability, and financial efficiency) of financial inclusion considered in this article, financial access turned out to be significant in explaining economic development in Africa. Even though Africa is far behind the rest of the continent in financial inclusiveness, some countries like South Africa and Seychelles have financially inclusive societies in terms of financial access. If Africa can build a financially inclusive society, the continent would block financial linkages in commercial banks' ability to create money for economic development. Policies that seek to maintain the soundness and stability of banks and other deposit-taking financial institutions are hitting the nail on the head.
The Impact of Electronic Word of Mouth and Brand Image on Online Purchase Decisions Moderated by Price Discount
Authors: Slamet Slamet , Prasetyo Bagus Putro Wahyu , Azmala Ilya
Published: March 2022

This study aims to analyze the impact of electronic word of mouth and brand image on online purchasing decisions moderated by price discounts. This study uses a quantitative research paradigm with an explanatory approach. The research instrument is a questionnaire designed to measure electronic word of mouth, brand image, price discount, and online purchase decisions. Data were collected from primary sources through surveys. The survey, as a data collection technique, was carried out in Malang City. Partial distribution of the questionnaire used google form and distributed directly to respondents. The research object is the Shopee platform, while the research subjects are millennials who have used the Shopee platform in the past year. The total number of respondents involved in this study was 100. Data analysis used two approaches namely categorization index analysis and multivariate regression. Study results show that electronic word of mouth is in a reasonably low category. The brand image has a high category, while the price discount has a reasonably high category. Hypothetically tested, electronic word mouth has no impact on purchasing decisions. However, when moderated by a price discount, it has an impact on purchasing decisions. Meanwhile, whether moderated by price discounts or not, the brand image variable had an impact on online purchasing decisions on the Shopee platform.
Pengelolaan Perpustakaan Sekolah Terautomasi Berbasis SLiMS 9(Bulian) Di SMPN 4 Lubuk Alung Kabupaten Padang Pariaman
Authors: Desriyeni Desriyeni , Ardoni Ardoni , Habiburrahman Habiburrahman
Published: March 2022

The purpose of this Community Partnership Program (PKM) activity is to solve school library problems in the application of information technology by providing understanding and skills in information technology-based school library management using the Senayan Library Management System (SLiMS) 9 Bulian application in accordance with the standards set for librarians or teachers. placed in the school library. In this activity, problems will be completely solved starting from understanding concepts and carrying out school library management practices by implementing a library automation system using the SLiMS 9 application. Judging from the priority problems set, the target output of the activity is that the librarian of SMPN 4 Lubuk Alung, Padang Pariaman is able to : (1) understand the meaning, nature, and function of information technology-based school libraries. At the end of the activity, a minimum of 75% of the PKM activity material can be mastered; (2) apply the knowledge gained in the management of an automated school library; and (3) the output target in the form of a process is that the SLiMS 9 application has been installed and used as a tool to replace various routine work in the library and library managers know and take advantage of various SLiMS 9 features that have been learned during the training, such as: data entry, label creation, barcoding, circulation services, membership, reporting, browsing, heading and subjecting. There is an increase in the ability of the target audience in understanding the understanding, concepts, and processes of managing and utilizing information technology-based school libraries.
THE INFLUENCE OF STAKEHOLDER ENGAGEMENT AND TRANSFORMATIONAL LEADERSHIP ON BUSINESS SUSTAINABILITY
Authors: Kurniawati Susanti , Sulaeman Ardika
Published: March 2022

This research is motivated by the low sustainability of soybean-based MSMEs (Micro Small Medium Enterprises) in West Java. This is due to the low long-term value given to stakeholders in the economic, social and environmental dimensions and the less-than-optimal role of leaders in realizing business sustainability. The purpose of this study is describing the business sustainability, stakeholder engagement, transformational leadership and analyzing the effect of transformational leadership and stakeholder engagement on business sustainability. This research was conducted using a survey method on 254 soybean-based SMEs consisting of tempe, tofu and soy sauce craftsmen in West Java. Data was collected by distributing a questionnaire, interviewing and observations of the unit of analysis. The data that has been collected was analyzed using structural equation modeling (SEM) analysis techniques. The results of this study stated that the business sustainability of soybean-based MSMEs was actually better in the social dimension and relatively less in the environmental dimension. The ability of transformational leaders to influence their employees to achieve goals is the highest ability, while the ability of forward-looking is the lowest than other dimensions. In building stakeholder engagement, the leader's ability to build trust is the highest, while business openness is the lowest compared to other capabilities. In this study, transformational leadership and stakeholder engagement affect business sustainability partially and simultaneously.
THE USE OF EMPLOYER BRANDING DIMENSIONS TO ATTRACT FRESH GRADUATES
Authors: Prasetyaningtyas Sekar Wulan , Sim Michelle , Triantoro Brian Hariman , Allen Allen
Published: March 2022

One of the obstacles in the company recruitment process is the change of labor force generation. Indonesia has already shifted the labor force to generation Z. This research aims to examine the influence of employer branding dimensions consisting of work environment, compensation and benefits, corporate reputation, corporate vision and leadership, and corporate social responsibility in attracting work interests. This cross-sectional study with an online questionnaire to 306 fresh graduate respondents domiciled in Jakarta, Bogor, Depok, Tangerang, South Tangerang, and Bekasi (Jabodetabek). Data analysis uses linear regression methods. The study results indicate that all employer branding variables positively affect the intention to apply for a job. This aspect needs to be considered by the company in increasing the intention to apply for a job from fresh graduate employees’ candidates who are currently generation Z. The work environment has the highest average value towards applying for a job. It can be due to the primary purpose of generation Z is choosing the company where they will work in the comfort of the workplace atmosphere.
Poética del exordio en la épica culta renacentista
Authors: Lara Garrido José
Published: March 2022

Las funciones que el exordio presenta en la tradición clásica del poema épico se modifican en la épica culta italiana que llega hasta la Gerusalemme de Tasso. Son programaciones de orden retórico que inciden conjuntamente en la épica culta española aquí estudiada en 65 obras comprendidas entre 1552 y 1605. Se categorizan las confirmaciones exordiales que van desde las apelaciones al lector a las simbolizaciones de la escritura, ocupando todo el espacio conformado por la historia y la ficción.
Tres pisadas de hombre de Antonio Prieto
Authors: Díez Romero Déborah
Published: March 2022

La «primera» novela de Antonio Prieto, Tres pisadas de hombre, fue galardonada con el Premio Planeta en 1955. A raíz de su lanzamiento hacia uno de los lugares más considerados dentro del orbe literario, fueron muchas las críticas que suscitó la obra, recreándose en la aparición de multiplicidad de opiniones que lo llevaron a ser considerado como la «joven promesa» de la novela española.
Acetaminophen pharmacokinetics in geese
Authors: Sartini Irene , Łebkowska-Wieruszewska Beata , Gbylik-Sikorska Małgorzata , Pietruk Konrad , Krawczyk Aleksandra , Gajda Anna , Lisowski Andrzej , Poapolathep Amnart , Giorgi Mario
Published: March 2022

OBJECTIVE

To evaluate the pharmacokinetics of acetaminophen (APAP) after single-dose IV and PO in the goose; to quantify APAP and its main metabolites in goose muscle, heart, lung, liver, and kidney; and to perform a histopathologic evaluation of goose stomach, duodenum, liver, and kidney tissues for potential signs of toxicity.

ANIMALS

24 geese.

PROCEDURES

Geese were randomly divided into 3 groups (n = 8). Group I received APAP (10 mg/kg) IV, and groups II and III received the same dose PO. Groups I and II were used for the pharmacokinetic assessment, and group III was used for the residue analysis and histopathologic evaluation. APAP and its metabolites were quantified in plasma and tissues by ultra–high-performance liquid chromatography–tandem mass spectrometry, and the pharmacokinetic analysis was performed using a noncompartmental approach.

RESULTS

APAP plasma concentrations were lower than those of the metabolites in similar selected time points after both treatments. After IV treatment, the APAP area under the curve value was statistically higher than that after PO administration, resulting in an oral bioavailability of 46%. In contrast, the area under the curve of the metabolites following PO administration was statistically higher than those found after IV administration. Tissue residues of APAP were highest in the liver, with an accumulation index > 1. Fatty degeneration of hepatocytes was observed 24 hours after administration of APAP.

CLINICAL RELEVANCE

In geese, treatment by PO administration of APAP shows incomplete absorption and a slight accumulation in lung and liver. Tissue alterations occurred in the liver at 24 hours, while no signs of toxicity were found in the other tested organs.
Occurrence of Ornithobacterium rhinotracheale in Polish turkey flocks
Authors: Kursa Olimpia , Tomczyk Grzegorz , Sawicka-Durkalec Anna
Published: March 2022

Introduction

Ornithobacterium rhinotracheale (ORT) causes significant economic losses to the poultry industry around the world. The bacterium often affects poultry as part of multiple infections causing very serious clinical signs that are usually not limited only to the respiratory system. This study’s main objective was the retrospective detection and identification of ORT in turkey flocks.

Material and Methods

ORT identification was performed in 6,225 samples taken from 133 different flocks between 2015 and 2020. Molecular methods were used, specifically real-time PCR and traditional PCR. We focused on partial 16S rRNA gene sequences of isolates, which were compared with sequences obtained from GenBank. The reaction products were analysed phylogenetically. Molecular methods indicating secondary infections was carried out, and the bacterial composition of the upper respiratory tract was 16S metasequenced for selected flocks to identify any other pathogens.

Results

The presence of ORT was detected in 30.83% of samples by real-time PCR and 28.57% by PCR. Phylogenetic analysis of the PCR products from the turkeys samples showed that their sequences resolved into two main genetic groups. Tests for the occurrence of secondary infections showed the presence of Mycoplasma gallisepticum and M. synoviae in some samples but the total absence of Bordetella avium. The upper respiratory tract in turkeys was dominated by two major phyla Firmicutes and Proteobacteria. At the genus level, the genera Ornithobacterium, Mycoplasma, Gallibacterium, Avibacterium, and Escherichia-Shigella were found which may include pathogenic bacteria that can cause clinical symptoms.

Conclusion

The results of the analysis of multiple infection carried out in flocks with respiratory signs are probably associated with outbreaks of ornithobacteriosis in turkey flocks in Poland.
W.Y. Evans Wentz the Fairy-Faith in Celtic Countries (1911) Letters from Evans Wentz to Sophia Morrison (1910-12)
Authors: Rbv Stephen Miller
Published: March 2022

Walter Yeeling Evans Wentz (1878-1965), is known for The Fairy-Faith in Celtic Countries published by Oxford University Press in 1911. Wentz’s personally gathered fairy beliefs in each of the six Celtic lands and the selections that appeared in The Fairy-Faith were introduced by a prominent figure in the Celtic Revival. In the case of the Isle of Man, it was Sophia Morrison (1859-1917), a leading light in the Manx Language Revival. Wentz had visited the Island late in 1909 during December. Discarded by Wentz at some stage were the letters, drafts, and proofs of The Fairy-Faith. That said, ten letters are extant from Wentz to Morrison and they are presented here in full following an introduction to set them in context and with a brief description of their salient content. They show the work that went into Morrison’s introduction, the editorial to-ing and fro-ing involved, and also the progress of The Fairy- Faith itself through Wentz’s own comments to Morrison.
Personalising EFL Courses for Online Learning
Authors: Smyshlyak K. V.
Published: March 2022

Over the recent decades, we have witnessed a considerable shift in an EFL (English as a foreign language) lesson from a teacher-centered to a student-centered one. This change can be attributed to the concept of personalised learning and teaching, which led to the relevancy of the study. The paper aims to describe the main principles of the course development and analyse how a personalised approach is realised in the new General English course from Skyeng online school. The author describes some general principles applied to the course modelling: the type of the syllabus, main andragogical principles, and principles of eﬀective language learning. The paper analyses what personalised learning is from the point of view of both: a teacher and a learner. In the results and discussion section, a description is provided of how the personalised approach works on the level of the whole course (the system of obligatory and optional lessons, 3 diﬀerent studying tracks, the choice of the homework volume, the choice of the tests and exams for the student) and on the level of the lesson modelling (various lesson patterns, extra slides for additional practice). The author also analyses her research, which shows that teachers do not tend to be ﬂexible when choosing the lesson materials and prefer the linear lesson track without changing the combination of lesson slides. This proved the need for such lesson models in Skyeng online school which would be designed to be quite ﬂexible in their structure. The represented approach to modelling a language course can be viewed as quite innovative and up-to-date and has proved to be eﬀective.
ФОРМУВАННЯ ПРОФЕСІЙНИХ КОМПЕТЕНТНОСТЕЙ МАЙБУТНІХ МАГІСТРІВ ПОЧАТКОВОЇ ОСВІТИ
Authors: Шквир Оксана , Дудчак Галина , Казакова Наталія , Сівак Наталія
Published: March 2022

У статті акцентовано увагу на необхідності визначення професійних компетентностей магістрів зі спеціальності 013 Початкова освіта та їх формування у майбутніх фахівців на другому рівні вищої освіти. Уточнено сутність поняття “професійна компетентність майбутнього магістра початкової освіти”. На основі вивчення професійних стандартів визначено перелік професійних компетентностей  вчителя початкових класів та викладача.  Висвітлено педагогічний досвід викладачів кафедри педагогіки Хмельницької гуманітарно-педагогічної академії щодо формування професійних компетентностей майбутніх магістрів початкової освіти.
МЕТОДИКА ФОРМУВАННЯ ВИКОНАВСЬКОЇ МАЙСТЕРНОСТІ СКРИПАЛЯ У ПЕДАГОГІЧНІЙ ДІЯЛЬНОСТІ ГЕОРГІЯ ПАВЛІЯ
Authors: Фрайт Іван , Чорний Юрій
Published: March 2022

У статті висвітлюється багатогранна практична методика викладання гри на скрипці видатного педагога, представника львівської скрипкової школи, професора Георгія Івановича Павлія, який у своїй діяльності синтезує найкращі досягнення вітчизняної та зарубіжної скрипкової школи.

Розкрито його педагогічну, творчу і наукову діяльність, яка відіграла важливу роль у розвитку скрипкового мистецтва України та зарубіжжя. Встановлено, що, поширюючи свою методику гри на скрипці, Г. Павлій виховав цілу плеяду талановитих музикантів-професіоналів, які активно пропагують його талант.
Enhancing Student Confidence in Diabetes Management Skills Through Pharmacist-Run Group Classes in a Community Library
Authors: Ginzburg Regina , Chim Christine
Published: March 2022

Purpose: To evaluate student pharmacists’ confidence after providing education within diabetes groups in a non-medical community setting.
Program Description: Three 8-week diabetes group courses were developed and executed within a local public library. The courses aimed to teach participants with diabetes how to effectively manage their medical condition to prevent future related complications. Student pharmacists were responsible for checking and recording the patients’ vitals, assisting in answering questions posed by the participants throughout the session, presenting different medication information each week, and creating a brochure which described the highlights of the specific week’s medication class. The student pharmacists were then surveyed regarding their confidence level in providing diabetes education in the future as well as their experience of working within these groups.
Summary: Seventeen student pharmacists participated in three 8-week sessions. The majority of the student pharmacists reported increased confidence in being able to provide diabetes education as well as newfound empathy for persons with diabetes on how to manage their medical condition.
Arterial hypotension during percutaneous procedures in the left atrium: It is not always pericardial tamponade!
Authors: Arabia Luis Antonio , Arrascue Luis Aguinaga
Published: March 2022

On the stage of left atrial percutaneous procedures a number of acute complications and their management have been described. In the current brief report, coronary air embolism, its acute manifestations, differential diagnosis and outcomes were presented in three patients who underwent cryoballoon ablation of atrial fibrillation and left appendage closure.
Sand Dune Stabilization by Hydrated Lime
Authors: Ismael Ndia Salim , Husein Hamed Humood , Mohammed Faiza Ibrahim
Published: March 2022

Formation and movement of sand dunes could be considered the most important problems thatsafer and destroy agricultural lands, domestic and industrial buildings. These dunes finally forma desertification state. The hard climate as high temperature and reduction in rainfall are themain factors affecting on this formation. This practical study is a trial to solve this problemthrough addition and covering the dunes by local material. Hydrated lime was used in this work,the lime was mixed with water in different ratios and covered a hills of sand. Three ratios of limewere selected to cover three sand hills with diameter 100 cm and height 50cm. The thickness ofthe lime layer is 6cm and covered all the hill. The hills were lifted for a year under the naturalcircumstances of sun shine, winds, rainfall and temperature. Results indicated that the hills werefixed and no sand were blown from dunes. Furthermore, some natural plants have been grownover them.
Spatial Analysis of the Solid Waste Bins in the Sectors of the City of Mosul "Environmental Study in Geographic Information Systems
Authors: Zenad Zainab Ali K.
Published: March 2022

An experimental study on a passive solar distiller in the Tikrit city on (latitude line"34 36oThe problem of solid waste in Mosul city is one of the most important daily problems that facesthe municipal and other institutions, because it consists eight sectors and those of varied in thepeople preparation, economic conditions and area, This study aimed to identify the spatialvariation of solid waste as well as the geographical distribution of bins numbers and spatialanalysis using geographic information systems. The study produced many maps of the binsnumber distribution geographically using buffer tools that used to determine the area served bya single bin, as well as the maps of the spatial analysis by Theissen polygons and IDWmethods. The study results proved the efficiency of IDW compared to Theissen polygonsmethod, because the analysis by polygons Theissen methods show only the capacity andefficiency of the bin to accommodate the solid waste at the same location, as well as of thegenerality and comprehensiveness at the area expense in the spatial description process unlikethe first type.
Studying the Effect of Load Direction Variation on the Performance of Three Tilted Pads Journal Bearing
Authors: Muhsin Ibrahem Ali
Published: March 2022

This research studied, theoretically, the performance of a tilted pad journal bearing. This bearing consists three inclined pads. These pads are distributed circumferentially around the journal. These pads can be adjusted in two ways: by changing the tilt angle of each pad _and by changing the circumferential position of the pads around the journal, relative to the external load direction, in order to obtain the following goals: (1) Maximum external load, (2) Maximum oil flow rate in order to carry out as much heat as possible, (3) Minimum power consumption, and (4) Control the attitude angle magnitude in order to control the stiffness and damping coefficients then improve bearing stability. The thickness of the oil film between the pads and the shaft surface had been obtained using an equation that was derived specially for this purpose. Then the pressure of each point on the three pads surfaces were also calculated using Reynolds equation which solved numerically using a computer program. The results showed that there is a certain direction for the external load (a specific value for
Industrial characteristics of renewable energy and spatial aggregation correlations in Beijing–Tianjin–Hebei
Authors: Wu Xiaotong , Zhou Yang , Cheng Changchun , Yang Shiliang
Published: March 2022

Beijing–Tianjin–Hebei is a key development zone in China, and the renewable energy industry is particularly concerned. This paper aims to combine spatial information with renewable energy industry to reveal the spatial-temporal evolution characteristics of industry and its driving factors. It is found that the industries in Beijing, Tianjin and Hebei show an obvious agglomeration pattern, with the renewable energy industry in the Beijing–Tianjin–Hebei region showing Moran’sI = 0.385579 during 2005–2010, Moran’sI = 0.319463 during 2010–2015, and Moran’sI = 0.329409 during 2015–2020. The global spatial autocorrelation analysis shows that the agglomeration level of the renewable energy industry in the Beijing–Tianjin–Hebei region has not increased, but the local spatial autocorrelation shows that the areas with higher transportation and business levels tend to be significantly agglomerated in space. Through the Moran index, it is found that the industry in Beijing–Tianjin–Hebei presents an obvious agglomeration pattern, and through the hotspot analysis, the industrial agglomeration is found mainly occurs in Beijing, Tianjin, Shijiazhuang and Zhangjiakou, which can be explained by the factor agglomeration effect brought by urbanization. However, we further calculated the location quotient, Herfindahl coefficient and Gini coefficient, and found significant regional differences in Beijing–Tianjin–Hebei region. For example, the unipolar agglomeration effect was weakening. Further three-phase space ellipse more vividly reveals the Beijing–Tianjin–Hebei region of renewable energy industry in the past 20 years continued to form the benign industrial expansion. Starting from the capital Beijing, the industry moved southwest, driving the development of renewable energy industry in Hebei and Tianjin, and promoting the coordinated development of the Beijing–Tianjin–Hebei economic circle.
Combined neuroendoscopic cyst wall fenestration and cyst-peritoneal shunt in an infant with glioependymal cyst
Authors: Irie Kohei , Shimogawa Takafumi , Mukae Nobutaka , Kuga Daisuke , Iwaki Toru , Mizoguchi Masahiro , Yoshimoto Koji
Published: March 2022

Background:

Glioependymal cysts (GECs) are rare, benign congenital intracranial cysts that account for 1% of all intracranial cysts. Surgical interventions are required for patients with symptomatic GECs. However, the optimal treatment remains controversial, especially in infants. Here, we report a male infant case of GECs that successfully underwent minimally invasive combined neuroendoscopic cyst wall fenestration and cyst-peritoneal (CP) shunt.

Case Description:

The boy was delivered transvaginally at 38 weeks and 6 days of gestation with no neurological deficits. Magnetic resonance imaging (MRI) at birth revealed multiple cysts with smooth and rounded borders and a non-enhancing wall in the right parieto-occipital region. The size of the cyst had increased rapidly compared to that of the prenatal MRI, which was performed at 37 weeks and 2 days. On the day of birth, Ommaya cerebrospinal fluid (CSF) reservoir was placed into the largest outer cyst. The patient underwent intermittent CSF drainage; however, he experienced occasional vomiting. At 2 months, he underwent combined neuroendoscopic cyst wall fenestration and CP shunt through a small hole. The patient’s postoperative course was uneventful and there was no recurrence of the cyst. The pathological diagnosis was GEC.

Conclusion:

Combined neuroendoscopic cyst wall fenestration and CP shunt are a minimally invasive and effective treatment for infants with GECs.
Soutenir la motivation scolaire des adolescents : comprendre et agir sur base de principes neuroéducatifs.
Authors: Peters Stéphanie
Published: March 2022

La motivation est un facteur clé largement reconnu pour assurer l’engagement et la persévérance dans l’action. C’est également le cas dans le domaine des apprentissages scolaires.  De nombreux modèles théoriques de la motivation, souvent complémentaires, sont disponibles dans la littérature. Cependant, les articles qui envisagent le processus motivationnel sous l’angle de la neuroéducation sont encore peu nombreux. C’est l’objectif de cet article, dans lequel la motivation à apprendre est présentée comme le résultat d’un calcul de probabilité de type couts – bénéfices. Le focus est placé sur les élèves du secondaire, avec une attention particulière aux spécificités de leur développement cérébral d’adolescents. Des pistes d’intervention sont avancées, en vue de créer des conditions propices à la motivation d’apprendre, soit en réduisant la perception des coûts de l’engagement dans l’apprentissage, soit en augmentant la perception de ses bénéfices.
A crystalline tri-thorium cluster: σ-aromaticity vs charge-shift bonding
Authors: Szczepanik Dariusz
Published: March 2022

Very recently, Boronski et al. reported the first thorium-thorium bond in a crystalline cluster prepared under normal experimental conditions. By using a range of experimental techniques and computational models, the authors found that the isolated actinide cluster contains at its heart two paired electrons delocalized over the tri-thorium ring. The recorded Raman spectrum allegedly confirmed the existence of a σ-aromatic three-center two-electron bond. In the following we demonstrate that the experimentally observed broad inelastic scattering bands between 60 and 135 cm-1, originally assigned by the authors to thorium-thorium vibrations, represent the combination of Th–Cl stretching and Th–Cl–Th bending modes, and they establish the existence of an unprecedented multicenter charge-shift bonding (ThCl2)3 rather than the σ-aromatic bonding Th3. In the light of the presented findings, the latter remains experimentally unproven and computationally questionable.
Rational Design of Amphiphilic Fluorinated Peptides: Evaluation of Self-Assembly Properties and Hydrogel Formation
Authors: Chowdhary Suvrat , Schmidt Robert Franz , Sahoo Anil Kumar , tom Dieck Tiemo , Hohmann Thomas , Schade Boris , Brademann-Jock Kerstin , Thünemann Andreas F. , Netz Roland R. , Gradzielski Michael , Koksch Beate
Published: March 2022

Advanced peptide-based nanomaterials composed of self-assembling peptides (SAPs) gain an emerging interest in pharmaceutical and biomedical applications. The introduction of fluorine into peptides, in fact, offers unique opportunities to tune their biophysical properties and intermolecular interactions. In particular, the degree of fluorination plays a crucial role in peptide engineering as it can be used to control the intensity of fluorine-specific interactions. Here, we designed and explored a series of amphipathic self-assembling peptides by incorporating the fluorinated amino acids (2S)-4-monofluoroethylglycine (MfeGly), (2S)-4,4-difluoroethylglycine (DfeGly) and (2S)-4,4,4-trifluoroethylglycine (TfeGly) as main components. This approach enabled studying the impact of fluorination on secondary structure formation and peptide self-assembly on a structural basis. We show that the interplay between polarity and hydrophobicity, both induced by varying degrees of side chain fluorination, affects peptide folding and leads to the generation of peptide hydrogels composed of fluorinated aliphatic amino acids. Molecular simulations revealed the formation of electrostatically driven intra-chain and inter-chain contact pairs caused by side chain fluorination. Our study provides a systematic report about the distinct features of fluorinated oligomeric peptides with potential applications as peptide-based biomaterials.
Stereocontrolled Total Synthesis of Bastimolide B using Iterative Homologation of Boronic Esters
Authors: Fiorito Daniele , Keskin Selbi , Bateman Joseph , George Malcolm , Noble Adam , Aggarwal Varinder
Published: March 2022

Bastimolide B is a polyhydroxy macrolide isolated from marine cyanobacteria displaying antimalarial activity. It features a dense array of hydroxylated stereogenic centers with 1,5-relationships along a hydrocarbon chain. These 1,5-polyols represent a particularly challenging motif for synthesis, as the remote position of the stereocenters hampers stereocontrol. Herein, we present a strategy for 1,5-polyol stereocontrolled synthesis based on iterative boronic ester homologation with enantiopure magnesium carbenoids. By merging boronic ester homologation and transition metal-catalyzed alkene hydroboration and diboration, the acyclic backbone of bastimolide B was rapidly assembled from readily available building blocks with full control over the remote stereocenters.
Spheroplasts preparation boosts the catalytic potential of a terpene cyclase
Authors: Benítez-Mateos Ana Isabel , Schneider Andreas , Hegarty Eimear , Hauer Bernhard , Paradisi Francesca
Published: March 2022

Squalene-hopene cyclases (SHCs) are a highly valuable and attractive class of membrane-bound enzymes as sustainable biotechnological tools to produce aromas and bioactive compounds at industrial scale. However, their application as whole-cell biocatalysts suffer from the outer cell membrane acting as a diffusion barrier for the highly hydrophobic substrate/product, while the use of purified enzymes leads to dramatic loss of stability. Here we present an unexplored strategy for biocatalysis: the application of SHC spheroplasts. By removing the outer cell membrane, we produced stable and substrate-accessible biocatalysts. SHC spheroplasts exhibited up to 100-fold higher activity than their whole-cell counterparts for the biotransformations of squalene, geranyl acetone, farnesol, and farnesyl acetone. Their catalytic ability was also higher than the purified enzyme for all high molecular weight terpenes. In addition, we introduce a new concept for the carrier-free immobilization of spheroplasts via crosslinking, CLS (crosslinked spheroplasts). The CLS maintained the same catalytic activity of the spheroplasts, offering additional advantages such as recycling and reuse. These timely solutions contribute not only to harness the catalytic potential of the SHCs, but also to make biocatalytic processes even greener and more cost-efficient.
Dampak Pandemi Covid-19 Terhadap Pasar Saham Di Indonesia
Authors: Saraswati Henny
Published: March 2022

This study aims to determine the factors that can affect financial distress in food and beverage companies listed on the Indonesia Stock Exchange in 2014-2018. The factors used are the size of the hood and financial distress.This type of research is an associative causal research with an ex post facto approach. Samples were taken using purposive sampling technique. A sample of 34 companies from 168 food and beverage companies listed on the Indonesia Stock Exchange in 2014-2018, so that the analyzed research data amounted to 170. The data analysis techniques used were descriptive statistics and logistic regression.The results of this study indicate that (1) Profit has no significant effect on predicting financial distress conditions. (2) Cash flow has no effect in predicting financial distress conditions. (3) Leverage has no effect in predicting financial distress conditions. And simultaneously this study states that earnings, cash flow and leverage do not affect predicting financial distress.
Nutritional profiles of Baccaurea macrocarpa fruit
Authors: Masriani  , Fadly D.
Published: March 2022

Some edible forest plants have been recognised as nutritional sources and may support
human health. Baccaurea macrocarpa is a forest fruit with limited nutritional information.
The nutritional value by determining proximates, minerals, and amino acid profile of skin,
flesh, and the seed of B. macrocarpa was investigated through this study. Determination
of the proximate composition was executed based on the AOAC. Estimation of energy
content in kilocalories (kcal/100 g) was calculated by summing the multiplication of each
protein, fat, and total carbohydrate. HPLC determined minerals and amino acids. The
results showed that B. macrocarpa fruit contained low levels of ash (0.32±0.03 -
1.64±0.05%), fat (0.24±0.03 - 5.98±0.21%), protein (0.44±0.51 - 2.73±0.11%) but a high
level of water (61.99±8.33 - 84.84±7.23%), fibre (7.91±2.31 - 18.83±1.03%), and
carbohydrates (13.40±0.32 - 27.66±3.13 %). The consumption of 100 g of this fruit may
provide energy intake around 2.9% to 8.8% of the 2000 kcal daily energy requirement. It
was rich in macro minerals P (60.88±5.71 - 720.95±54.67 µg/g), Ca (149.94±13.73 -
515.32±23.33 µg/g), and Mg (137.98±14.76 - 315.18±24.51 µg/g), and a sufficient
amount of micro mineral Zn (6.68±1.32 - 15.29±3.10 µg/g), Fe (0.02±0.00 - 20.97±17.32
µg/g), Cu (0.75±0.00 - 4.94±0.11 µg/g), dan Mn (0.22±0.00 - 2.42±0.01 µg/g). This fruit
contained an adequate amount of essential amino acids and an abundance of nonessential
amino acids (ƩTAAE/ƩTAA = 1.02 - 1.64%). In conclusion, the results indicated that this
forest fruit is potentially a good source of nutrition.
Rural Electrification and Sustainable Planning of Sukuk Financing within the Isolated Communities in Nigeria: Using Investment and Blockchain Technology
Authors: Muhammad Tijjani , Dauda Suleiman Alhaji , Bukar Aisha
Published: March 2022

The Renewable Energy system enhances rural communities' development in the country, specifically in North-East and North-West, Nigeria. The ability to overcome extreme poverty and improve their living conditions is related to the renewable energy technology available. The rural electrification planning approach consists of socioeconomic, environmental, and institutional sustainability dimensions. This study establishes specific objectives to achieve sustainability in rural electrification programs. Conceptual frameworks are proposed for achieving universal access anywhere with similar experiences. The methodology is proposed to 3000 isolated communities in North-East and North-West, Nigeria that lack electricity. Three different strategic approaches are formulated as a research-based investment analysis framework. Confirmatory Factor Analysis under Structural Equation Modelling is shown in Figure 2. While figure 3 addressed the technology aspect through blockchain technology. The findings of this work are intended to contribute to the improvement of rural electrification programs with Renewable Energy (RE) of the solar system.
Hedonik Motivasyonun Drone ile Teslimata Yönelik Tutum Üzerindeki Etkisi: Ağızdan Ağıza İletişimin Aracılık Rolü
Authors: Aydın İbrahim
Published: March 2022

Nihai tüketicilere ürünlerin ulaştırılması amacıyla gelecekte kullanımının yaygın olması beklenen drone’ların daha hızlı ve uygun maliyetli teslimat sağlaması, fosil yakıtla çalışan araçlara göre daha çevreci olması gibi avantajları vardır. Bu çalışmanın amacı drone’lara yönelik hedonik motivasyonun ağızdan ağıza iletişim ve tüketicilerin ürün dağıtımında drone kullanılmasına yönelik tutumu üzerindeki etkilerinin yanında hedonik motivasyon ve tutum arasındaki ilişkide ağızdan ağıza iletişimin aracılık rolünü araştırmaktır. Çalışmanın örneklemini Türkiye’de yaşayan 350 kişi oluşturmaktadır. Çalışmanın örneklemine online anket ve kartopu örnekleme yöntemiyle ulaşılmıştır. Elde edilen verilerin analizinde doğrudan etkiler için basit linear regresyon analizi, dolaylı etkiler için process macro kullanılmıştır. Elde edilen sonuçlara göre, drone’lara yönelik hedonik motivasyonun ağızdan ağıza iletişim ve drone kullanılmasına yönelik tutum üzerinde doğrudan olumlu etkisi vardır. Ayrıca drone’lara yönelik hedonik motivasyonun, ağızdan ağıza iletişim aracılığıyla drone kullanılmasına yönelik tutumda dolaylı ve olumlu etkisi bulunmaktadır. Ağızdan ağıza iletişimin, drone kullanılmasına yönelik tutumda doğrudan olumlu etkisinin olması elde edilen başka bir sonuçtur. İleride drone ile dağıtım gerçekleştirecek firmalar açısından tüketicilerde hedonik motivasyonun oluşturulması veya arttırılması oldukça önemlidir.
Pre-exposure prophylaxis as prevention strategy in the HIV transmission: characterization of the user
Authors: Alves Ferreira Marlene , Cristina Rodrigues da Silva Nádia , De Paula Ludmila , Andrade Heuler Souza
Published: March 2022

Introduction: The combined HIV prevention is the current strategy of prevention employed in coping with this disease. It makes combined use of biomedical, behavioral and structural interventions, applied at the level of individuals. This study aimed to characterize the user of PrEP of a hospital of Minas Gerais and his relationship with this proposal. Outline: Descriptive study based on secondary data, with a quantitative approach, carried out in 2020. To obtain the data, information available by the service itself, in the prophylactic care of users, was used. Results: Of the 80 users analyzed, 41.3% were between 22 and 30 years old, 86.3% were single and 80% considered themselves homosexuals, 37.5% claimed to have had a relationship with HIV+ people without using condoms, 100% of users underwent rapid testing for HIV. Implications: The findings demonstrate that PrEP has significantly contributed to HIV prevention. However, given the risk behavior of many users, there is a need for managers and health professionals to improve this intervention.
Lesiones cutáneas en Lupus eritematoso sistémico
Authors: Orbea Jácome Edison Andrés , Orbea Jácome Luis Fernando , Narváez Álvarez Carolina Misshell , Mafla Cuasapaz Alejandra Estefanía
Published: March 2022

El lupus eritematoso (LES) es una enfermedad autoinmune crónica, donde el sistema inmunológico ataca a sus propias células produciendo infamación y daño, debido a la unión de nuestros anticuerpos a las células del organismo y al depósito de complejos antígeno-anticuerpo. Las lesiones no específicas pueden estar asociadas a otras enfermedades autoinmunes e incluyen cambios vasculares. A pesar de su complejidad; los mecanismos patógenos comienzan a ser comprendidos involucrando a factores genéticos, hormonales y ambientales que conducen a una alteración del sistema inmunitario, con una respuesta de autoreactividad frente a las estructuras propias del organismo. Uno de los factores que se ha planteado como precursor de autoinmunidad es el estrés y factores inherentes a la personalidad de los pacientes. Entendiendo que la piel ha de ser uno de los órganos principales órganos afectados se plantea la investigación con el fin de encontrar las lesiones cutáneas de dicha enfermedad y realizar una revisión bibliográfica para analizar y sintetizar las características de esta enfermedad y las actualizaciones en las publicaciones académicas de la misma. Los avances en las publicaciones científicas llevan no solo a conocer mejor el desarrollo y tratamiento de la enfermedad, sino que por supuesto se traduce en una mejora en las expectativas de vida de los pacientes diagnosticados. La evolución en el estudio del LES es considerable, en ninguno de los trabajos analizados se descartan los hallazgos en el tema puesto que la enfermedad tiene distintas formas de manifestación y desarrollo. La mayoría de los estudios se centran en dos temas específicos que son el descarte de otras enfermedades con manifestaciones clínicas parecidas que pueden llevar a un diagnóstico erróneo y por otra parte la profundización de los tratamientos a utilizar. Se sabe que la genética, las condiciones climáticas, la raza, la edad y el sexo influyen en la aparición, evolución y pronóstico de la enfermedad, se hace necesario realizar estudios locales de la incidencia y tratamientos efectivos para concretar guías clínicas funcionales para el manejo, diagnostico y tratamiento de las lesiones cutáneas en LES.