bluuebunny/crossref_metadata_2025 huggingface dataset:
Frequency and clinical significance of human papilloma virus in oral cancer - A study from Kerala
Authors: Raj Divya , George Preethi Sara , Lakshmi S , Kumar R Rejnish , Thommachan Kainickal Cessel , Rafi Malu , Anantharaman Devasena , Pillai M Radhakrishna , Ramadas K
Published: February 2025

Background:

Oral cancer is a major health problem in India. Recently an increase in the oral cancer incidence among young individuals without any habits was observed, which may be due to Human Papilloma Virus (HPV). However, information on the prevalence of HPV in oral cancer in India is sparse. This study aims to document the frequency of HPV16 infection in oral squamous cell carcinoma (SCC) and to study its correlation with treatment outcome.

Methods:

Paraffin-embedded tissue blocks of 183 patients with SCC of the oral cavity were studied. HPV16 prevalence was detected by a polymerase chain reaction and expression of p16INK4a was analyzed by immunohistochemistry. This was correlated with clinical outcomes.

Results:

The prevalence of HPV 16 was 6.6% and all were carcinoma tongue. All HPV-positive patients showed intense expression of p16INK4a. The five-year overall survival (OS) and disease-free survival (DFS) for HPV positive patients were higher compared to HPV negative patients (100% versus 74.5% and 100% versus 70.8% respectively). The five-year OS and DFS for patients with p16INK4a intense expression were also higher compared to p16INK4a weak expression (91.2% versus 57.4% and 82% versus 22.5% respectively). Five-year OS and DFS of patients with HPV16 positivity and p16INK4a intense expression were significantly higher than patients with HPV negative and p16INK4a weak expression (100% versus 54.7% and 100% versus 22.5% respectively).

Conclusion:

The frequency of HPV16 positivity in oral cancer was low in this study with a site predilection to the oral tongue. p16INK4a expression did not correlate with HPV status. A better treatment outcome was observed in HPV-positive cancers. We also observed better treatment outcomes in patients with p16INK4A overexpression irrespective of HPV status.
Expression of the long noncoding RNA CASC2 in acute myeloid leukemia and its prognostic significance
Authors: Peng Sida , Yang Qingqing , Pan Yuhang , Li Huan , Wang Jiani , Hu Pan , Zhang Nana
Published: February 2025

Background:

Cancer susceptibility candidate 2 (CASC2) was found underexpressed in multiple types of human malignancies. However, the specific role of CASC2 in AML remains uncertain. The purpose of this study is to explore the expression of CASC2 in patients with AML and healthy donors and its prognostic significance in AML.

Methods:

Total RNA was isolated from bone marrow samples or peripheral blood samples of 87 patients with AML and 26 healthy adult donors. The expression of long noncoding RNA CASC2 was detected by quantitative real-time polymerase chain reaction. The association between CASC2 expression and other clinicopathological factors as well as its prognosis significance were analyzed.

Results:

The peripheral blood mononuclear cell (PBMC) expression level of CASC2 in AML was significantly lower than that in the healthy control cohort (P = 0.0048), and in the bone marrow samples, CASC2 was significantly upregulated in patients with AML after the achievement of CR (median value: 0.041, range: 0.015–0.064) compared with that at newly diagnosis (median value: 0.017, range: 0.008–0.041) (P = 0.002). The expression of CASC2 had a significant relationship with complete remission (P = 0.019). Survival data assessed by Kaplan–Meier curves showed that patients with lower CASC2 expression had shorter overall survival and disease-free survival than patients with higher CASC2 expression. Finally, Cox proportional hazards analysis demonstrated that CASC2 was an independent prognostic indicator for both OS (P = 0.013) and DFS (P = 0.001) of AML.

Conclusions:

LncRNA CASC2 may serve as a new molecular biomarker for the early diagnosis and of AML, and may be an independent prognostic factor affecting the survival of patients with AML.
Incidence of postoperative pulmonary complications and associated risk factors after major oncosurgeries: Prospective observational study
Authors: Agarwal Shilpi , Garg Rakesh , Bhatnagar Sushma , Mishra Seema , Bharati Sachidanand Jee , Gupta Nishkarsh , Kumar Vinod
Published: February 2025

Background:

Postoperative pulmonary complications (PPCs) are defined heterogeneously and have major adverse effects in increasing morbidity. Oncosurgeries themselves are complex, are of long duration, and extensive handling of body tissues occurs in them, leading to various complications including PPCs. So, we conducted this prospective study intending to find the incidence and risk factors for PPCs in patients undergoing major oncosurgeries.

Methods:

This prospective observational study was conducted after obtaining institutional ethical approval in patients undergoing major oncosurgeries. The demographic, preoperative, and intraoperative details were noted, and patients were followed in the postoperative period for the occurrence of PPC till discharge. Assess Respiratory Risk in Surgical Patients in Catalonia (ARISCAT) score was used to predict the occurrence of PPC. Data were analyzed using multivariable regression analysis for the risk factors, and the Chi-square trend was used to see the trend of PPC with the change in ARISCAT score.

Results:

The overall incidence of PPC in patients undergoing major oncosurgeries was 28.05%. The most common PPCs were respiratory insufficiency (19.2%) and atelectasis (17.6%). The highest incidence of PPC was found in thoracotomies (41.6%), followed by cytoreductive surgeries (40.6%). The risk factors for PPCs included body mass index (BMI) <18.5 or >25 kg/m2, smoking, use of nasogastric tube, age >60 years, and albumin <3.5 g/dL. Patients with low ARISCAT scores had a low incidence of PPC compared to those with high and intermediate ARISCAT scores.

Conclusion:

The incidence of PPC in patients undergoing major oncosurgeries was 28.05% in our study. The independent risk factors for PPC in oncological surgeries were BMI <18.5 kg/m2 or >25 kg/m2, use of nasogastric tube, age <60 years, serum albumin <3.5 g/dL, and smoking.
Giant basal cell carcinoma of the back – A tumor of the neglect
Authors: Malik Deepika , Bala S.V.S. , Pandey Laxman , Seam Rajeev K.
Published: February 2025

Giant basal cell carcinomas (GBCCs) represent only 0.5–1% of all basal carcinomas and are known to occur and behave differently than other basal cell carcinomas. We report a 93-year-old gentleman with GBCC of the back of superficial spreading histological type who we treated with radical radiotherapy with excellent local control. Nonaggressive histological subtypes of GBCC particularly the superficial type can be well managed with radiotherapy, especially in the elderly, and should be adequately utilized in carefully selected patients.
Prognostic value of psoas muscle index in metastatic renal cell carcinoma patients treated with anti-VEGF therapy
Authors: Arıkan Rukiye , Demircioğlu Özlem , Özgüven Salih , Demircan Nazım Can , Alan Özkan , Telli Tuğba Akın , Işık Selver , Başoğlu Tuğba , Çelebi Abdussamed , Yaşar Alper , Şahin Ceren Özge , Ercelep Özlem , Dane Faysal , Cimşit Canan , Yumuk Perran Fulden
Published: February 2025

Background:

We aimed to investigate the relationship between sarcopenia, which is defined by using psoas muscle index (PMI), and survival outcomes in patients with metastatic renal cell carcinoma (mRCC).

Methods:

This is a retrospective descriptive study of mRCC treated with first-line anti-vascular endothelial growth factor (anti-VEGF) therapy. The prognostic significance of PMI for progression-free survival (PFS) and overall survival (OS) was evaluated by univariate and multivariate analyses. Additionally, the skeletal muscle index (SMI) was calculated and correlation analysis was performed between PMI and SMI.

Results:

Eighty-eight patients with a median age of 60 years (interquartile range [IQR], 51–66) were included. Median PFS with first-line treatment was 6 (95% confidence interval [CI]: 2.9–9.03) months and median OS was 17 (95% CI: 10.6–23.03) months in all patients. Mean PMI was 5.71 (standard deviation [SD]: ±1.41) in women and 8.30 (SD: ±2.04) in men. Forty-seven (53.4%) patients according to PMI and 49 (55.6%) patients according to SMI were accepted as sarcopenic. The overall correlation between SMI and PMI was strong (rs = 0.73). PFS was numerically shorter in the low-PMI and low-SMI groups than the high-PMI and high-SMI groups, but it did not reach statistical significance. In univariate analyses, International Metastatic Renal Cell Carcinoma Database Consortium (IMDC) risk score, anti-VEGF agent option, PMI, and SMI were significant prognostic factors for OS (P < 0.05 each). In multivariate analyses for OS, while IMDC score (P < 0.001) and PMI (P = 0.04) were significant independent prognostic factors according to multivariate analysis-1, IMDC score (P < 0.001) and SMI (P = 0.01) were significant independent prognostic factors according to multivariate analysis-2.

Conclusions:

Pretreatment PMI has a strong correlation with SMI and is an independent prognostic factor for OS in patients with mRCC.
Indian experience of Afatinib for EGFR mutation-positive advanced lung adenocarcinoma a real-world retrospective study
Authors: Batra Ullas , Sharma Mansi , Jain Parveen , Narayan Satya , Jain Arpit , Soni Satyajeet , Nathany Shrinidhi
Published: February 2025

Introduction:

Afatinib, a second-generation EGFR TKI, was approved in 2015 for the treatment of metastatic NSCLC in India. We aimed to evaluate the clinical outcomes of Afatinib therapy in a real-world setting.

Patients and Methods:

Electronic medical records of 43 patients who received Afatinib for advanced EGFR-mutant advanced NSCLC were retrospectively reviewed. In total, 43 patients were analyzed of whom 31 received Afatinib in first-line therapy.

Results:

The patient population was younger than Lux-Lung 3. Median PFS was 15.03 months with 95% CI (7.8–18.3 months). At 14% maturity OS was not reached. However, 95% CI lower limit was 34.9 months. The most common adverse reactions were skin rash and diarrhea which were managed with dose alteration without compromising efficacy.

Conclusion:

Currently, there are multiple first-line strategies to manage advanced NSCLC in India including EGFR TKIs. To the best of our knowledge, this is the first real-world study published from India which looks into the efficacy of Afatinib in advanced NSCLC. Afatinib showed a manageable safety profile and comparable efficacy in real-world practice compared with those described in previous studies.
Recommendations on Selection of Antifungal Agents for the Treatment of Superficial Mycoses in People Living with Diabetes Mellitus
Authors: Idris Amina Muhammad , Getso Muhammad Ibrahim , Hafiz Taysir R. , Kabuga Auwal Idris
Published: February 2025

Introduction:

In general, empirical treatment has been the main approach for the treatment of superficial fungal infections (SFIs). People living with diabetes mellitus (PLWDM) are at increased risk of having SFIs because of immunosuppression, autonomic neuropathy, impaired peripheral circulation and inability to maintain good personal hygiene.

Aim:

The study aims to carry out mycological assessment of superficial body lesions involving the hair, nails, skin and foot ulcers in PLWDM.

Materials and Method:

A cross-sectional study was conducted on a cohort of 300 PLWDM recruited from two major diabetes treatment centres in Kano, Murtala Muhammad Specialist Hospital and Muhammad Abdullahi Wase Teaching Hospital., Kano Nigeria. Sabouraud Dextrose Agar was used for fungal cultures, while identification of yeast and mould isolates was by Gram staining, Germ tube test, Chrom agar, lacto phenol cotton blue mount and slide cultures. Antifungal susceptibility testing was achieved by agar well diffusion method with the discs selected based on Clinical and Laboratory Standards Institute (CLSI) recommendations.

Results:

The frequency distribution of the lesions examined includes tinea pedis (250), tinea unguium (30), foot ulcers (19) and tinea cruris (1). Fungi isolated include Trichophyton mentagrophytes, Trichophyton rubrum, Epidermophyton floccosum, Candida albicans, Candida tropicalis, Nakaseomyces glabratus, Aspergillus niger, Aspergillus fumigatus, Aspergillus flavus and Fusarium spps. All isolates demonstrated high sensitivity to itraconazole, clotrimazole and ketoconazole, however, there was high resistance to fluconazole.

Conclusion:

The findings of the study showed high prevalence of SFIs in PLWDM with different species of fungi isolated, and itraconazole, clotrimazole and ketoconazole, either as monotherapy or in combinations are the best treatment options.
Pattern of Injury Distribution following Fall from Height
Authors: Josiah Ngibo Terver , Ibrahim Jatto Hamzah
Published: February 2025

Background:

Falls from height are significant cause of trauma globally. It is defined as an event where an individual falls to the ground from an elevated level. In particular, falls from trees, buildings, and other elevated structures have been identified as a frequent cause of traumatic injuries in Nigeria. Mango trees are a common source of falls, as they are frequently climbed by children and adults to collect fruit.

Objectives:

The study aimed to assess the demographic distribution, injury patterns, management outcomes of patients with fall-related injuries, and to provide recommendations for the prevention of falls.

Method:

A prospective hospital-based study was carried out between September 2021 and August 2022, at the Accident and Emergency department. All patients presenting to the Accident and Emergency department with injuries resulting from a fall from height were recruited.

Results:

Majority of the patients were male (87.5%), with 50% of cases occurring in children under the age of 10 years. Most falls occurred from mango trees with 62.5% of incidents. Long bone fractures were the most frequently sustained injury (50%), followed by head injuries (37.5%). A statistically significant association was found between age and height of fall, with younger individuals more likely to fall from heights >3 m. The management outcomes revealed that 62.5% of patients were successfully discharged, while 12.5% died and 18.75% were discharged against medical advice (DAMA).

Conclusion:

Falls from height are a major cause of injuries in rural Jigawa State, especially among young males. Long bone fractures and head injuries are the most common types of injuries, and while most patients are successfully treated, there are concerning rates of death and DAMA. Preventive measures, such as discouraging children from climbing trees and providing alternative methods for fruit collection, are recommended. Further public health interventions and educational campaigns are necessary to reduce the risk of fall-related injuries.
Evaluation of Outcomes Following Endovenous Laser Therapy for Chronic Venous Insufficiency on a Daycare Basis in a Tertiary Healthcare Centre: A Prospective Cohort Study
Authors: Pathak Swati , Sharma Aditya , Yadav Rajeshwar
Published: February 2025

Background:

Chronic venous insufficiency (CVI) often presents with the development of incompetent short saphenous vein or great saphenous vein (GSV), resulting in a condition known as varicose veins.

Materials and Methods:

The present study was conducted with the aim of evaluating the outcomes and recurrence following endovenous laser therapy (EVLT) for CVI by discharging the patient on the same day following the procedure.

Results:

In this study, only 4 patients developed recurrence following varicose vein treatment out of 102 patients with EVLT on a daycare basis. An occlusion of GSV along with its branches was achieved in most of the cases with self-limiting adverse effects and very few recurrence rates in the follow-up period.

Conclusions:

Relief of symptoms and a significant improvement in the appearance of varicose veins were noted four–six months after initial treatment, and pain was greatly resolved in all the treated limbs.
Pattern of Dysglycaemia and Its Associated Risk Factors amongst Civil Servants in an Urban Community in Southern Nigeria
Authors: Ejenobo Osaro Enogie , Ohenhen Oluwatoyin A. , Ekhator Noruwa Patience , Aigbe Adrian , Edo Andrew Efosa
Published: February 2025

Background:

The global prevalence of diabetes mellitus (DM) is estimated to be 10.5% and majority of those affected are in the economically productive age group. A significant proportion of civil servants are considered at high risk for development of diabetes because of the sedentary nature of their job.

Objectives:

This study aimed to determine the prevalence and associated risk factors for dysglycaemia amongst civil servants in an urban community.

Methods:

This study was a cross-sectional study with a total of 84 participants. Data on the sociodemographic, medical history, family and social history of the participants were collected using a participant-filled questionnaire. Anthropometric measurements (height, weight, waist circumference and hip circumference), blood pressure and fasting plasma glucose levels were obtained. Impaired fasting glucose (IFG) and DM were defined using the World Health Organisation criteria.

Results:

The mean (standard deviation) age of the participants was 38 (9.7) years. The prevalence of IFG and diabetes was 14.3% and 7.1%, respectively. The overall prevalence of dysglycaemia was 21%. There was no significant difference in prevalence of dysglycaemia amongst males and females. Hypertension and obesity were present in 29.8% and 13.1% of participants, respectively. The risk factors significantly associated with dysglycaemia were hypertension and a positive family history of DM.

Conclusion:

This study demonstrated a high prevalence of dysglycaemia in the study population. There is a need for targeted interventional programmes aimed at reducing the risk factors for dysglycaemia as well as providing regular screening for civil servants.
Immunologic and Radiographic Status in Newly Diagnosed Adults with Human Immunodeficiency Viral Infection at a General Outpatient Clinic of a Tertiary Hospital, North-west, Nigeria
Authors: Abubakar Ramatu , Baduku Tokan Silas , Isuwa Amos Kadashi , Abdulhamid Karimah Saleh
Published: February 2025

Background:

Human immunodeficiency virus (HIV) targets the body’s immune system and renders the body susceptible to varieties of opportunistic infections. Tuberculosis (TB) is one of the common opportunistic infections in person with HIV Infection.

Aim:

The study aimed to radiologically screen for pulmonary TB (PTB) and determine immunological status of persons newly diagnosed with HIV-infection attending HIV Counselling and Testing (HCT) unit at General Out-Patient Clinic (GOPC) of Barau Dikko Teaching Hospital (BDTH), Kaduna.

Materials and Methods:

This is a retrospective study from records of all cases diagnosed newly with HIV infection at HCT unit, GOPD, BDTH, Kaduna, from 1st January, 2023 to 31st December, 2023. A total of 120 folders were retrieved and analysed. Data on age, sex, blood pressure, immunological status, chest X-ray (CXR) and body mass index were analysed by means of descriptive statistics.

Results:

High proportions of the patients/clients (27.5%) were within the age of 31–40 years. Majority were female (62%). The cluster of differentiation 4 (CD4) counts of most of the patients/clients 55 (45.8%) was below 200 cells/mm3 and only 6 (5%) of the CXRs findings were suggestive of PTB.

Conclusion:

The immunologic status of most patients/clients was found to be very low at diagnosis and 5% of patients had CXR features suggestive of PTB. There should be regular screening of HIV infection at GOPC and routine CXR for newly diagnosed HIV-infected persons.
Management of Chemotherapy-induced Oral Mucositis: A Report of Two Cases and a Review of the Literature
Authors: Mogaji Ibrahim Kolawole , Adewale Adedotun Adewuyi , Oyetola Elijah Olufemi , Owotade Foluso John
Published: February 2025

Background:

Chemotherapy-induced oral mucositis (OM) is a common complication of cancer chemotherapy and is usually accompanied by severe pain. Studies indicate that about half of the patients undergoing standard chemotherapy and more than two-thirds of those undergoing high-dose chemotherapy will develop mucositis. The management has been challenging due to scarce evidence-based protocol.

Case Reports:

We present two cases of OM following chemotherapy at Obafemi Awolowo Teaching Hospitals. Case 1 is a 34-year-old woman receiving chemotherapy for choriocarcinoma with vaginal metastases who developed severe OM (WHO Grade 4) at the 5th cycle. Case 2 is a 72-year-old male being treated for bone marrow lymphoma. He developed severe OM (WHO Grade 4) with protracted healing. Preventive measures were instituted for the next cycle of chemotherapy. Both patients had oral candidiasis. Intensive oral care with the management of symptoms was instituted in treating both patients.

Conclusion:

Symptoms management and instituting preventive measures remain the mainstay of management of OM.
Insufficient Samples in Office Endometrial Biopsies: Incidence, Risk Factors and Outcomes of Repeat Procedures
Authors: Aldakhil Lateefa Othman
Published: February 2025

Aims:

The aim of the study was to evaluate the prevalence and risk factors of insufficient samples in office endometrial biopsies, and the outcomes of repeat biopsies.

Settings and Design:

This study was conducted in a gynaecological outpatient clinic. A retrospective chart review was performed on patients who underwent office endometrial biopsies.

Subjects and Methods:

This is a retrospective study analysing 1826 endometrial biopsies performed in a healthcare institution from 2011 to 2017.

Statistical Analysis Used:

Statistical analyses used SPSS version 23 included one-way ANOVA, Chi-square tests and t-tests to examine relationships between various study variables and abnormal uterine bleeding (AUB), with significance set at P ≤ 0.05.

Results:

The study found that 16% of initial biopsies yielded insufficient samples, with a higher prevalence amongst post-menopausal women. Obesity and post-menopausal status were identified as significant risk factors for malignancy. In cases where initial biopsies were inadequate, repeat biopsies were performed in 57.4% of patients, revealing predominantly benign pathology and a malignancy risk of <1%.

Conclusions:

This study underscores the importance of considering the patients’ menopausal status, and body mass index status when interpreting biopsy reports for insufficient samples. These factors should be given due consideration when deciding to repeat biopsies and during patient counseling to improve the adequacy of samples and reduce the need for repeat procedures. By addressing these variables, healthcare providers can enhance diagnostic accuracy and patient management in cases of AUB.
Difference in Outcomes among Hypertensive Patients with or without Government-funded Healthcare Coverage: A Retrospective Review of Electronic Medical Records in a Large Private Hospital in Abuja
Authors: Ede Victor , Osuala Uchenna , Alozie Eucharia , Akindele Abiola , Opurum Peace , Ofoli Joshua , Onu Adamu , Wada Ibrahim
Published: February 2025

Background:

In Africa, particularly in countries like Nigeria, poor health outcomes are prevalent, with many people lacking access to essential health services. While global research highlights disparities in health outcomes for individuals with chronic conditions based on their health insurance type or payment method, there is a lack of empirical studies in Africa investigating these disparities.

Objective:

This study aimed to identify differences in blood pressure (BP) and hospital stay outcomes between hypertensive patients who use publicly funded insurance schemes and those who use private health coverage types in Nigeria.

Materials and Methods:

A retrospective review was conducted of electronic medical records of 1086 patients with essential hypertension (International Classification of Diseases 10) from January 2017 to January 2018 at a private Hospital in Abuja. Multinomial logistic regression analysis was used to estimate the odds ratios (OR) for adverse outcomes in patients with government and non-government-funded health coverage.

Results:

We found that patients with government-funded insurance were more likely to have elevated diastolic BP [DBP] (OR: 1.65, 95% confidence interval [CI]: 1.39–1.95, P < 0.001). Females were less likely to have elevated systolic BP (OR 0.77, 95% CI 0.64–0.91, P = 0.003) and DBP (OR 0.83, 95% CI 0.70–0.99, P = 0.044) when compared to males.

Conclusions:

While public healthcare coverage is improving in Nigeria, insured patients still face a limited selection of medical services and may not receive specific therapy types even when deemed necessary, compared to privately insured patients. This may contribute to the difference in outcomes seen among these patients.
Growing choroidal osteoma: Treated by proton beam radiation
Authors: Sedaghat Ahad , Aronow Mary E. , Singh Arun D.
Published: February 2025

Choroidal osteoma is a rare, slow-growing intraocular osseous tumor. Limited information is available regarding the management of tumors growing toward the fovea. In this study, we present two cases of growing choroidal osteoma that were successfully treated with proton beam radiation therapy. In one case, tumor growth toward the fovea in a 12-year-old female was treated with proton beam radiation as the primary intervention. In the other, proton beam radiation was used after photodynamic therapy failed to control tumor growth in a 16-year-old female with choroidal osteoma. Both cases demonstrated sustained tumor growth cessation for 42 and 38 months, respectively. Low-dose proton beam radiation appears to be an effective treatment option to halt tumor growth and preserve vision, though long-term follow-up is essential.
ANALYSIS OF FISH CONSUMPTION HABITS AND THE PERCENTAGE OF STUNTING INCIDENCE IN CHILDREN UNDER FIVE IN SAMPOINIET ACEH JAYA REGENCY
Authors: Hidayattullah Mhd. , Najikhah Nur , Putri Rosalia , Fitriani Fitriani
Published: February 2025

Stunting Stunting adalah kondisi kronis yang menunjukkan malnutrisi jangka panjang dan telah menjadi perhatian serius di Indonesia, memengaruhi sekitar 37,2% anak di bawah usia lima tahun. Penelitian ini berfokus pada analisis hubungan antara konsumsi ikan dan stunting pada balita di Sampoiniet, Kabupaten Aceh Jaya. Penelitian dilakukan selama satu bulan, yang melibatkan observasi langsung di lapangan, serta penggunaan kuesioner dan wawancara terstruktur. Metode yang digunakan adalah deskriptif analitis, dengan uji Chi-square untuk memberikan gambaran hubungan antara konsumsi ikan dan terjadinya stunting pada balita di Sampoiniet, Kabupaten Aceh Jaya. Hasil analisis menunjukkan bahwa 22,2% anak yang sering mengonsumsi ikan mengalami stunting, sementara 24,1% anak yang jarang mengonsumsi ikan mengalami stunting. Selain itu, 9,3% anak yang sering mengonsumsi ikan tidak mengalami stunting, sedangkan 44,4% anak yang jarang mengonsumsi ikan tidak mengalami stunting. Nilai p sebesar 0,015, yang lebih kecil dari 0,05, menunjukkan adanya hubungan yang signifikan antara konsumsi ikan dan stunting.
AbstractStuntingis a chronic condition that indicates long-term malnutrition and has become a serious concern in Indonesia, affecting approximately 37.2% of children under five years of age. This study focuses on analyzing the relationship between fish consumption and stunting in toddlers in the Sampoiniet of Aceh Jaya Regency. The research was conducted over the course of one month, involving direct field observations, as well as the use of questionnaires and structured interviews. The method employed was descriptive analytical, with Chi-square testing to provide an overview of the relationship between fish consumption and the occurrence of stunting in toddlers in Sampoiniet, Aceh Jaya Regency. The analysis results show that 22.2% of children who frequently consume fish experience stunting, while 24.1% of children who rarely consume fish experience stunting. Additionally, 9.3% of children who frequently consume fish do not experience stunting, whereas 44.4% of children who rarely consume fish do not experience stunting. The p-value of 0.015, which is less than 0.05, indicates a significant relationship between fish consumption and stunting.
PENGEMBANGAN LKPD BERBASIS KEARIFAN LOKAL PADA PEMBELAJARAN IPS DENGAN MENGGUNAKAN MODEL COOPERATIVE LEARNING KELAS V SDN 83 LUBUKLINGGAU
Authors: Fitriyani Restia , Hamdan Hamdan , Valen Andri
Published: February 2025

Penelitian ini bertujuan untuk mengembangkan bahan ajar berbentuk LKPD berbasis kearifan lokal untuk siswa kelas V Sekolah Dasar yang valid, praktis dan efektif. Jenis penelitian ini yaitu Penelitian dan Pengembangan (Resarch and Development) dengan model pengembangan ADDIE. Teknik pengumpulan data melalui wawancara, observasi, angket, tes, dan dokumentasi dengan subjek penelitian yaitu siswa kelas V SD Negeri 83 Lubuklinggau. Berdasarkan hasil analisis uji validasi LKPD berbasis kearifan lokal  yang dinilai oleh tiga ahli yaitu, ahli bahasa, ahli media, dan ahli materi memenuhi kriteria kevalidan dengan skor rata-rata 0,85. Sedangkan dari hasil analisis penilaian lembar kepraktisan guru dan siswa di peroleh bahwa LKPD berbasis kearifan lokal memenuhi kriteria praktis dengan skor rata-rata 91,41%. Kemudian analisis penilaian keefektifan diperoleh skor N-Gain rata-rata 0,68 dengan kategori sedang. Berdasarkan hasil penelitian dapat disimpulkan bahwa bahan ajar LKPD berbasis kearifan lokal materi jenis usaha ekonomi terbukti valid, praktis, dan efektif sehingga layak digunakan dalam proses pembelajaran di kelas V SDN 83 Lubuklinggau.AbstractThis research aims to develop teaching materials in the form of LKPD based on local wisdom for fifth grade elementary school students that are valid, practical and effective. This type of research is Research and Development (Resarch and Development) with the ADDIE development model. Data collection techniques through interviews, observation, questionnaires, tests and documentation with research subjects, namely fifth grade students at SD Negeri 83 Lubuklinggau. Based on the results of the validation test analysis of local wisdom-based LKPD which was assessed by three experts, namely, language experts, media experts and material experts, they met the validity criteria with an average score of 0.85. Meanwhile, from the results of the analysis of teacher and student practicality sheet assessments, it was found that the local wisdom-based LKPD met the practical criteria with an average score of 91.41%. Then analysis of the effectiveness assessment obtained an average N-Gain score of 0.68 in the medium category. Based on the research results, it can be concluded that the LKPD teaching materials based on local wisdom regarding economic business types have proven to be valid, practical and effective so they are suitable for use in the learning process in class V at SDN 83 Lubuklinggau.
PENGARUH METODE PEER TUTORING BERBANTUAN VIDEO ANIMASI TERHADAP HASIL BELAJAR PENDIDIKAN PANCASILA SISWA SDN 8 SUWAWAL
Authors: Musfiroh Lilik Hidayatul , Choirin Attalina Syailin Nichla , Hamidaturrohmah Hamidaturrohmah
Published: February 2025

Pemilihan metode pembelajaran yang kurang tept menjadi penyebab rendahnya hasil belajar siswa. Dilakukannya riset ini bertujuan untuk mengetahui bagaimana hasil belajar pendidikan Pancasila siswa kelas V SDN 8 Suwawal dipengaruhi oleh metode peer tutoring. Penelitian yang peneliti laksanakan berdesain one group pretest-postest dan bersifat kuantitatif. Siswa kelas V menjadi populasi dan sampel yang dipilih untuk digunakan dalam riset ini. Temuan dalam penelitian ini memperlihatkan bagaimana pemakaian metode peer tutoring berbantuan video animasi bisa berdampak pada peningkatan hasil belajar. setelah dilaksanakannya postest, siswa memperoleh rata-rata 87,33 dan 55,67 pada pretest. Selain itu, kesimpulan pengujian hipotesis yang dilakukan memakai uji t dan uji regresi linier sederhana memperlihatkan adanya pengaruh yang signifikan terhadap hasil belajar siswa. Metode peer tutoring yang didukung oleh video animasi dapat digunakan guna mendorong peningkatan hasil belajar siswa.AbstractThe selestion of inappropiate learning methods is a cause of studesnts’ low academic performance. The research aims to determine how the learning outcomes of Pancasila education for fifth-grade students at SDN 8 Suwawal are influenced by the peer tutoring method. The research conducted by the researcher is designed as a one group pretest-postest and is a quantitative nature. Fifth-grade students are the population and sample selected for use in the research. The findings in this research show how the use of peer tutoring assisted by animated videos can impact the improvement of learning outcomes. After the postest was conducted, the students achieved an average of 87,33 and 55,67 on the pretest. In addition, the conclusions from the hypothesis testing conducted using the t-test and simple linear regression test show a significant effect on students’ learning outcomes. The peer tutoring method supported by animated videos can be used to encourage improvements in student learning outcomes.
Green Skill and Justice
Authors: Ennals Richard
Published: February 2025

This paper is written from within a series of concurrent discourses and dialogues over the last 50 years, when I have been a researcher, research manager, writer and editor. This meant starting from a UK perspective of Skill and Justice, with the work of John Bellers, then moving to Scandinavia, and ending with a European synthesis and international systematisation, where we can regard our ongoing differences as a crucial resource for sustainable development.
Keywords: Action Research, Collaboration, Development Coalition, Dialogue, Differences,Justice, Skill, Systematisation, Transition
Karaburun – Kumköy (İstanbul) Arası Kıyı Şeridinde Meydana Gelen Değişimlerin DSAS Aracı İle Antropo-Jeomorfolojik Analizi
Authors: Uzun Murat
Published: February 2025

Kıyı birimleri, unsurları, dinamikleri, hızı ve süreçlerine etki eden antropojenik koşullar, çizgisel ve alansal olarak kıyı jeomorfolojisinde değişimlere doğrudan ve dolaylı olarak etki etmektedir. Belirtilen kapsamda bu çalışmada, İstanbul’un Karadeniz kıyısında yer alan ve madencilik faaliyetleri ile büyük değişimlere uğrayan Karaburun-Kumköy arası kıyı şeridi antropo-jeomorfolojik yaklaşım ve Sayısal Kıyı Çizigisi Analiz Sistemi (DSAS) aracının kullanımı ile incelenmiştir. Çalışmada, 1970 yılına ait ortofoto, USGS’den alınan 1975, 1980, 1985, 1990, 1995, 2000, 2005, 2010, 2015, 2020 ve 2023 yıllarına ait Landsat uydu görüntüleri kullanılmıştır. Ortofoto üzerinden manuel, uydu görüntüleri üzerinden ise Normalize Fark Su İndisi (NDWI) ve eşik yöntemi kullanılarak kıyı çizgileri üretilmiştir. Daha sonra kıyı çizgileri üzerinden DSAS aracında yer alan NSM, SCE, EPR ve LRR istatistikleri kullanılarak çizgisel analizler yapılmıştır. Çizgisel analizlerden sonra kıyıda meydana alansal analizler yapılmış, değişimin kökeni doğal ve antropojenik olarak sınıflandırılmıştır. Analizler ilk olarak 1970-2023 yılları arasında 12 ayrı kıyı çizgisi üzerinden yapılmıştır. Daha sonra dönemsel olarak kıyı değişimlerini ortaya koymak amacıyla ardışık periyotlar üzerinden çizgisel ve alansal analizler uygulanmıştır. Çalışmanın sonucunda çizgisel, alansal değişimler periyotlar halinde incelenmiş, grid analizi ile antropo-jeomorfolojik kapsamda kıyıdaki değişim yoğunluğu incelenmiştir. Elde edilen bulgulardan kıyı çizgisi uzunluğunun 1970’de 36,4 km’den 2023’de 42,5 km’ye ulaştığı, girinti çıkıntı yapısının dönemsel olarak değişkenlik gösterdiği saptanmıştır. Dönemsel olarak kıyı çizgisinin en yüksek 998 m ilerlediği (1990-1995), -1314 m gerilediği (1995-2000) tespit edilmiştir. İnceleme sahasında değişen tüm kıyı zonunun %73’ünde antropojenik kökenli jeomorfolojik değişim yoğunluğunun çok yüksek düzeyde olduğu saptanmıştır.
Developing a New Testing Methodology for Honey Authentication
Authors:   Food Standards Agency, Anastasiadi Dr Maria , Kevei Dr Zoltan , Dodd Sophie , Shehata Mennatullah , Karimi Zahra , Mosca Dr Sara , Matousek Prof. Pavel
Published: February 2025

Honey is a valuable and nutritious food product, and its popularity is increasing globally driven by consumers demand for a healthier and more sustainable diet. However, honey is at risk of fraudulent practices such as the addition of exogenous sugars in the form of cheaper plant-based syrups including corn, rice, and sugar beet syrup. Honey authentication is of the utmost importance, but existing methods are not sufficient to detect all types of sugar syrups used for adulteration and at present there is no single method for honey authenticity testing.

The aim of this project was to investigate a) the suitability of Spatially offset Raman Spectroscopy (SORS), a non-invasive technique used to acquire measurements through packaging, for detecting the type and percentage of exogenous sugar adulteration in honey and b) to develop DNA markers (DNA barcoding) to identify the presence of DNA from plant sources such as rice and sugar beet which are used for making sugar syrups used for honey adulteration.
Mercury-Induced Oxidative Stress and Neuropathologic Changes in the Prefrontal Cortex of Wistar Rats
Authors:   Department of Medical Laboratory Science, Faculty of Basic Clinical Sciences, University of Ilorin, Ilorin, Nigeria, Adeniyi Temidayo , Moronkeji Akinpelu ,   Department of Medical Laboratory Science, Faculty of Allied Health Sciences, University of Medical Science, Ondo-City, Nigeria, Oluwatunase Gideon ,   Department of Anatomy, Faculty of Basic Medical Sciences, University of Medical Sciences, Ondo City, Nigeria, Adekomi Adedayo ,   Department of Anatomy, Faculty of Basic Medical Sciences, College of Health Sciences, Osun State University, Osogbo, Nigeria, Adunmo Godwin ,   Department of Medical Laboratory Science, Faculty of Basic Clinical Sciences, University of Ilorin, Ilorin, Nigeria
Published: February 2025

Access to clean water is necessary for human, animal, and environmental health. Anthropogenic human activities such as mining, agriculture, and continuous pollution from industrial waste, as well as population growth, continue to compromise the quality of water. The neurodegenerative impact of mercury with a similar concentration as obtained from waterways on the prefrontal cortex of Wistar rats was studied. Twenty adult rats were randomised into two groups: a control group and a 0.001 mg/L mercury (II) thiocyanate (Hg(SCN)2) group, ad libitum for 65 days, after which the animals were euthanised via cervical dislocation. Blood and tissue samples were obtained for analyses of oxidative stress biomarkers: superoxide dismutase (SOD), glutathione peroxidase (GPx), malondialdehyde (MDA), hydrogen peroxide (H2O2), histological, and glial fibrillary acidic protein (GFAP) and inducible nitric oxide synthase (iNOS) immunohistochemical evaluation. Statistical data were analysed using a t-test, set at p < 0.05. When comparing the mercury-treated groups to the control, a significant difference was observed in the SOD, GPx, MDA, and H2O2 values, with cellular alterations evident in the mercury-treated rats. Additionally, mercury treatment resulted in the distortion of the cortical histoarchitecture with intense immunoreactivity of GFAP and iNOS suggesting neuroinflammation. This study highlighted that mercury exposure induced oxidative stress and led to distortion in the histoarchitecture of the prefrontal cortex of adult Wistar rats
A influência de programas brasileiros de transferência de renda na qualidade da dieta e na segurança alimentar dos beneficiários
Authors: Goulart Suellen , Domingues do Amaral Ravazzani Edilceia
Published: February 2025

O estudo objetivou compreender se o incremento de renda oferecido por programas brasileiros de transferência de renda influencia positivamente na segurança alimentar e nutricional das famílias participantes, como também analisou a qualidade da dieta dos indivíduos e uma possível intensificação na procura por alimentos com menores valores nutricionais. Tratou-se de uma pesquisa transversal, descritiva, com uma abordagem qualitativa e quantitativa. A amostra final foi composta por 51 beneficiários, de ambos os sexos, maiores de 18 anos, de diferentes regiões do Brasil e que recebiam o auxílio por mais de três meses. Para levantamento dos dados foi aplicado um questionário eletrônico contendo vinte e duas perguntas. Os resultados apontaram que 82% dos beneficiários apresentavam insegurança alimentar e nutricional. A maior parte dos participantes relataram que o auxílio não interferiu na compra de alimentos industrializados e que o benefício não modificou a alimentação da família. Em relação a qualidade da alimentação, foi identificado predominância de alimentos básicos, em detrimento dos alimentos industrializados. Conclui-se que os programas não garantem a SAN dos beneficiários e que não interferem no consumo de produtos considerados não saudáveis, sendo a alimentação desse público baseada em alimentos de melhor qualidade nutricional.
Palavras-chave: Segurança alimentar e nutricional. Políticas públicas. Saúde pública. Direitos humanos.
Fault-Tolerant Event-Driven Systems- Techniques and Best Practices
Authors:   Software Architect and Technical Product Owner, USA, Chavan Ashwin
Published: February 2025

Reliability is an important feature in modern distributed, event-driven systems to provide simple, easy-to-manage, and fault-tolerant solutions that refrain
from degrading into system failures. It is becoming a widespread solution for formulating microservices, serverless, and development of different cloudnative structures. Asynchronous architectures are distinguished by their interconnectedness and geographical dispersion, making them susceptible to
failures. This paper aims to analyze some essential fault-tolerant approaches and technologies with the help of real-world examples of significant tech
giants such as Netflix, Uber, and GitHub to highlight the problems and solutions in this area. Techniques like redundancy and replication, idempotency,
circuit breakers, retry mechanism and event sourcing are considered for their parts in system reliability. Furthermore, more sophisticated techniques such
as graceful degradation, systems that heal independently, and sharding are discussed for their ability to improve availability in partial failure scenarios.
The use of strategies such as monitoring and observability, as well as fallbacks, are also discussed in this regard. New directions, such as applying Artificial
Intelligence in fault detection and Blockchain applications, can positively affect the systems' reliability. In this approach, case studies show how Netflix will
maintain uninterrupted streaming with the help of regional redundancy, and Uber will maintain transactional consistency with the help of event sourcing
and sagas. GitHub also uses graceful degradation and circuit breaker techniques to support basic functionalities during blackouts. Such considerations
illustrate that fault tolerance is essential to improve competitive advantage and customer trust and enable business continuity. This paper encapsulates
detailed information and practical solutions that Architects, Developers and Business Executives need to build sustainable, high-availability, fault-tolerant,
event-driven systems for a complex computing environment.
Linguistique et biologie : de l’idéologie scientifique au scientisme
Authors: Toutain Anne-Gaëlle
Published: February 2025

In this article, we show that the incursions of linguists into biology, from Schleicher through aphasiology to evolutionary linguistics, have created an unchanged space, the permanence of which lies in the absence of a break with the representation of language as an entity. This break, made by Saussure, nonetheless remained a dead letter in linguistics, whose relationship with biology has since been placed under the sign of scientific ideology, in the sense of Georges Canguilhem, coupled with reductionism. These relationships are established in place of a definition of language, and within the framework of the definition of common knowledge. Theoretical elaboration is then replaced by the spatialization and temporalization of this definition, spatialization and temporalization constituting the elective axes, respectively, of aphasiology and evolutionary linguistics.
Traduire « De la double essence du langage » en Russe
Authors: Zolotukhin Denis
Published: February 2025

The translation of Saussurean texts and terminology has become a science in its own right. The discovery of new documents during the 20th century provided material that not only advanced this field but also presented numerous challenges, compelling translators to rethink existing translations. The aim of this paper is to demonstrate the features of the translation process into Russian of the manuscripts titled De la double essence du langage discovered in 1996. Going through the history of existing Russian translations of Saussure’s texts, the author takes into consideration terminological, philological and epistemological aspects of the translation of this text which remains largely unknown to Russian scholars, as well as suggesting strategies that can be applied to solve different issues caused by the particular form, content and context of these manuscripts.
F. de Saussure and inner Speech. A reading proposal of CLG 98
Authors: Fanelli Franco
Published: February 2025

The institutionalization of reading at the court of Versailles is embodied by the librarians, the men readers or even the women readers of the royal family to whom this article is dedicated and on whom sources are lacking. It traces the context of the creation of the office of woman reader in 1749 and analyses the trajectories of the women appointed to this position until the Revolution, revealing their social belonging and the dynamics at work at the time of their designation. It appears that through the interplay of clienteles, the patronage or matrimonial strategies, the women readers seek to consolidate the position of their relatives within the commensality, giving rise to a progressive organization of women’s networks around the function. Benefiting from an enlightened education, they value their skills and talents in the artistic and cultural fields and intervene during sociability times dedicated to leisure. The women readers thus illustrate the affirmation of a feminine knowledge at court, which become a place of intellectual promotion for women.
PENINGKATAN KETERAMPILAN KOMUNIKASI KELOMPOK INFORMASI MASYARAKAT UNTUK PENGEMBANGAN DESA WISATA DEWI SAMBI
Authors: Muhsin Habib , Sulistyowati Fadjarini , Irsasri Irsasri , Chandra Ade , Riyadi L Irvan
Published: February 2025

Desa wisata diharapkan dapat mengubah dan meningkatkan citra daerah menjadi tujuan yang berdaya guna, berhasil guna, dan handal. Untuk mengembangkan SDM agar mampu mengelola desa wisata Dewi Sambi, diperlukan peningkatan keterampilan komunikasi. Kegiatan pengabdian Prodi Ilmu Komunikasi STPMD “APMD” melibatkan pelatihan keterampilan komunikasi kepada anggota Kelompok Informasi Masyarakat (KIM), yang berisikan anak-anak muda, sehingga mereka dapat menata, mengelola, dan mengoptimalkan informasi kepada masyarakat luas. Pengabdian ini bertujuan: 1) mendampingi KIM untuk meningkatkan keterampilan komunikasi, khususnya kemampuan berbicara di depan umum; 2) melatih penyusunan pesan tertulis (berita) terkait info wisata maupun program-program desa; dan 3) melatih keterampilan dalam mengelola media untuk mempromosikan obyek wisata Sambirejo. Metode yang digunakan meliputi observasi lapangan, ceramah, diskusi, praktik, dan pendampingan. Sasaran pengabdian adalah 30 anggota KIM di Kalurahan Sambirejo. Kegiatan ini dilakukan selama bulan April 2024 dalam bentuk pelatihan peningkatan keterampilan komunikasi. Materi pelatihan meliputi teknik public speaking, kemampuan menulis berita, dan pengelolaan konten media. Hasil kegiatan menunjukkan bahwa peserta dapat mempraktikkan keterampilan dengan baik, terlihat dari peningkatan kepercayaan diri dalam berbicara di depan umum, kemampuan membuat berita dengan unsur 5W+1H, dan pengelolaan media sosial.