bluuebunny/crossref_metadata_2025 huggingface dataset:
Window-of-Opportunity Study of Valproic Acid in Breast Cancer Testing a Gene Expression Biomarker
Authors: Cohen Adam L. , Neumayer Leigh , Boucher Ken , Factor Rachel E. , Shrestha Gajendra , Wade Mark , Lamb John G. , Arbogast Kylee , Piccolo Stephen R. , Riegert Joanna , Schabel Matthias , Bild Andrea H. , Werner Theresa L.
Published: July 2017

Purpose

The anticancer activity of valproic acid (VPA) is attributed to the inhibition of histone deacetylase. We previously published the genomically derived sensitivity signature for VPA (GDSS-VPA), a gene expression biomarker that predicts breast cancer sensitivity to VPA in vitro and in vivo. We conducted a window-of-opportunity study that examined the tolerability of VPA and the ability of the GDSS-VPA to predict biologic changes in breast tumors after treatment with VPA.

Patients and Methods

Eligible women had untreated breast cancer with breast tumors larger than 1.5 cm. After a biopsy, women were given VPA for 7 to 12 days, increasing from 30 mg/kg/d orally divided into two doses per day to a maximum of 50 mg/kg/d. After VPA treatment, serum VPA level was measured and then breast surgery or biopsy was performed. Tumor proliferation was assessed by using Ki-67 immunohistochemistry. Histone acetylation of peripheral blood mononuclear cells was assessed by Western blot. Dynamic contrast-enhanced magnetic resonance imaging scans were performed before and after VPA treatment.

Results

Thirty women were evaluable. The median age was 54 years (range, 31-73 years). Fifty-two percent of women tolerated VPA at 50 mg/kg/d, but 10% missed more than two doses as a result of adverse events. Grade 3 adverse events included vomiting and diarrhea (one patient) and fatigue (one patient). The end serum VPA level correlated with a change in histone acetylation of peripheral blood mononuclear cells (ρ = 0.451; P = .024). Fifty percent of women (three of six) with triple-negative breast cancer had a Ki-67 reduction of at least 10% compared with 17% of other women. Women whose tumors had higher GDSS-VPA were more likely to have a Ki-67 decrease of at least 10% (area under the curve, 0.66).

Conclusion

VPA was well tolerated and there was a significant correlation between serum VPA levels and histone acetylation. VPA treatment caused a decrease in proliferation of breast tumors. The genomic biomarker correlated with decreased proliferation. Inhibition of histone deacetylase is a valid strategy for drug development in triple-negative breast cancer using gene expression biomarkers.
Prospective Feasibility Study for Using Cell-Free Circulating Tumor DNA–Guided Therapy in Refractory Metastatic Solid Cancers: An Interim Analysis
Authors: Kim Seung Tae , Banks Kimberly C. , Lee Se-Hoon , Kim Kyung , Park Joon Oh , Park Se Hoon , Park Young Suk , Lim Ho Yeong , Kang Won Ki , Lanman Richard B. , Talasaz AmirAli , Park Keunchil , Lee Jeeyun
Published: July 2017

Purpose

Retrospective studies have demonstrated that cell-free circulating tumor DNA (ctDNA) hotspot testing predicts matched therapy response to first- and second-line therapies in patients with advanced non–small-cell lung cancer (NSCLC). However, no prospective outcomes studies have evaluated ctDNA-guided matched therapy decision making on the basis of comprehensive plasma genomic testing including all four major classes of alterations. Here, we report the clinical utility of this approach in advanced solid tumor cancers.

Patients and Methods

We conducted a multiple parallel cohort, open-label, clinical trial using ctDNA-guided matched therapy when tissue was insufficient or unobtainable for next-generation sequencing. Plasma-based digital sequencing identified point mutations in 70 genes and indels, fusions, and copy number amplifications in selected genes. Patients with prespecified targetable alterations in metastatic NSCLC, gastric cancer (GC), and other cancers were matched to several independent targeted agent trials at a tertiary academic center.

Results

Somatic alterations were detected in 59 patients with GC (78%), and 25 patients (33%) had targetable alterations ( ERBB2, n = 11; MET, n = 5; FGFR2, n = 3; PIK3CA, n = 6). In NSCLC, 62 patients (85%) had somatic alterations, and 34 (47%) had targetable alterations ( EGFR, n = 29; ALK, n = 2; RET, n = 1; ERBB2, n = 2). After confirmation of ctDNA findings on tissue (to meet trial eligibility criteria), 10 patients with GC and 17 patients with NSCLC received molecularly matched therapy. Response rate and disease control rate were 67% and 100%, respectively, in GC and 87% and 100%, respectively, in NSCLC. Response was independent of targeted alteration variant allele fraction in NSCLC ( P = .63).

Conclusion

To our knowledge, this is the first prospective feasibility study of comprehensive ctDNA-guided treatment in advanced GC and lung cancers. Response rates in this interim analysis are similar to those in tissue-based targeted therapy studies.
Parental Perspectives on Whole-Exome Sequencing in Pediatric Cancer: A Typology of Perceived Utility
Authors: Malek Janet , Slashinski Melody J. , Robinson Jill O. , Gutierrez Amanda M. , Parsons D. Williams , Plon Sharon E. , McCullough Laurence B. , McGuire Amy L.
Published: July 2017

Purpose

To explore how parents of pediatric patients with cancer perceived the utility of clinical tumor and germline whole-exome sequencing (WES) results.

Patients and Methods

We conducted longitudinal interviews with parents of a diverse pediatric cancer population before disclosure of WES results (n = 64), then 1 to 8 months (n = 33) after disclosure. Interview transcripts were analyzed using a thematic qualitative approach.

Results

Parents identified a broad range of types of utility for their child’s WES results. Even when results did not affect their child’s current treatment, they expressed optimism about future clinical utility for their child, themselves, and other family members. Parents also reported experiencing psychological utility including peace of mind, relief of guilt, and satisfaction of curiosity. Pragmatic utility, such as the ability to plan for the future and make better reproductive decisions, was also described.

Conclusion

Parents of pediatric patients with cancer perceive WES to have broad utility, including psychological and pragmatic utility, even if there is no direct impact on clinical care. Additional research will need to consider how the value of genomic information should be characterized, how risks and benefits should be described, and how these results should inform recommendations and decisions about using WES.
Drug-Related Pneumonitis in the Era of Precision Cancer Therapy
Authors: Nishino Mizuki , Hatabu Hiroto , Hodi F. Stephen , Ramaiya Nikhil H.
Published: July 2017

Drug-related pneumonitis as a result of novel cancer therapy provides new challenges for providers of cancer care in the era of precision medicine. Awareness of this emerging entity and knowledge of its manifestations and management guidelines are essential for state-of-the-art practice of clinical oncology. Here, we provide a detailed review of drug-related pneumonitis that develops during precision cancer therapies using immune-checkpoint inhibitors and molecular targeting agents, and we summarize the emerging data that have been obtained by recent investigations to provide a state-of-the-art overview for clinicians involved in cancer care. We focus on immune-checkpoint inhibitor–related pneumonitis, which is an immune-related adverse event of growing interest and increasing clinical significance in current oncology practice that has rapidly expanding access to these agents. Clinical characteristics, radiographic spectrum, and risk factors and outcome of pneumonitis are described for each class of agents, and current treatment guidelines and monitoring recommendations are discussed. This review also indicates the area of unmet clinical need and provides direction for future investigations, as well as emphasizing the importance of a multidisciplinary approach to further understand the mechanisms, develop methods for accurate diagnosis, and optimize management guidelines of drug-related pneumonitis in the era of precision oncology.
Constructing a Sacred Chronology: How the Nova Scotian Institute of Science Made the Mi’kmaq a People without Prehistory
Authors: Lelièvre Michelle A.
Published: July 2017

In the latter half of the nineteenth century, the Mi’kmaq were the focus of two moments in the development of the public sphere in the British settler colony of Nova Scotia. One moment saw concern for the Mi’kmaq’s welfare increase and the focus of that concern become fixed on “civilizing” through assimilation. Another was a growing scientific curiosity expressed through the founding of intellectual organizations such the Nova Scotian Institute of Science, and often at odds with prevailing religious beliefs, which adhered to the “sacred chronology” of the Bible. These moments converged in the addresses on cultural history made by members of the Nova Scotian Institute of Science between 1864 and 1912. The interpretations offered by the institute’s members demonstrate an increasing separation of the contemporary Mi’kmaq from the precontact past of the province, thus constructing a chronology that—if not biblically sacred—was sacrosanct to the narrative of progress that underlay the settler project in Nova Scotia.
Στάσεις γονέων με παιδί προσχολικής ηλικίας για την προσαρμογή των παιδιών που πάσχουν από σακχαρώδη διαβήτη
Authors: Μπρουσκέλη (Vassiliki Brouskeli) Βασιλική , Παπδοπούλου (Papadopoulou) Ευδοκία (Eudokia)
Published: July 2017

Η παρούσα μελέτη διερευνά τις στάσεις γονέων με παιδιά που δεν πάσχουν από Σακχαρώδη Διαβήτη σε θέματα κοινωνικής και σχολικής προσαρμογής παιδιών με διαβήτη καθώς και της επίδρασης της ασθένειας στην οικογένεια του παιδιού. Το δείγμα που επιλέχθηκε αποτελούνταν από 170 γυναίκες και από 38 άντρες οι οποίοι ήταν γονείς παιδιών που φοιτούσαν σε νηπιαγωγείο στην ευρύτερη περιοχή της Βόρειας Ελλάδας. Η πλειονότητα των ερωτηθέντων είχε γνώση του όρου «ινσουλινοεξαρτόμενος σακχαρώδης διαβήτης (ΙΣΔ) ή διαβήτης τύπου 1» καθώς και του όρου «παιδικός διαβήτης». Όσον αφορά την επίδραση της ασθένειας του παιδιού στην οικογένεια, πολύ μεγάλο ποσοστό αυτών έδειξε να την αντιλαμβάνεται ως ιδιαίτερα σημαντική σε θέματα καθημερινότητας και ψυχοκοινωνικής ισορροπίας. Ωστόσο, μικρό ποσοστό των συμμετεχόντων θεώρησε ότι επηρεάζεται σοβαρά η επικοινωνία μεταξύ των μελών και η διαθεσιμότητα των γονιών του άρρωστου παιδιού προς τα άλλα μέλη της οικογένειας. Επιπρόσθετα, οι μισοί περίπου αυτών θεώρησαν ότι πλήττεται σοβαρά η οικονομική κατάσταση της οικογένειας. Οι συμμετέχοντες, ανεξαρτήτως του εκπαιδευτικού επιπέδου τους, θεωρούν ότι το εκπαιδευτικό σύστημα αδυνατεί να υποστηρίξει το παιδί που πάσχει καθώς και ότι η σχετική κατάρτιση του εκπαιδευτικού είναι ανεπαρκής, ενώ παράλληλα αναγνώρισαν την ανάγκη για ενδονοσοκομειακή εκπαίδευση. Συμπερασματικά, οι γονείς παιδιών προσχολικής ηλικίας, ως φορείς της άτυπης εκπαίδευσης και συχνά της μοναδικής εκπαίδευσης που λαμβάνουν τα συγκεκριμένα παιδιά περί ζητημάτων χρόνιων ασθενειών, δείχνουν να κατανοούν την κατάσταση που αντιμετωπίζει το παιδί που πάσχει από διαβήτη και η οικογένειά του. Επιπλέον, δείχνουν να έχουν αντιληφθεί την ένδεια των συστημάτων υποστήριξης του παιδιού και της οικογένειας στη χώρα μας. Προτείνονται παρεμβάσεις με στόχο τη συμβουλευτική γονέων, την επιμόρφωση των εκπαιδευτικών, τη συνεργασία της οικογένειας με το σχολείο καθώς και σχολικά προγράμματα εξοικείωσης των παιδιών με τις χρόνιες ασθένειες.
Recent advances in understanding eosinophil biology
Authors: Klion Amy
Published: July 2017

With the advent of novel therapies targeting eosinophils, there has been renewed interest in understanding the basic biology of this unique cell. In this context, murine models and human studies have continued to highlight the role of the eosinophil in homeostatic functions and immunoregulation. This review will focus on recent advances in our understanding of eosinophil biology that are likely to have important consequences on the development and consequences of eosinophil-targeted therapies. Given the breadth of the topic, the discussion will be limited to three areas of interest: the eosinophil life cycle, eosinophil heterogeneity, and mechanisms of cell-cell communication.
Expert Communities of the Siberian and Far Eastern Federal Districts of the Factors and Conditions for the Unification of the Peoples of Russia, Ukraine and Belarus at the Beginning of the 21st Century
Authors: Григорьев  , Grigorev S. , Трофимова  , Trofimova R
Published: July 2017

The data characterizing the demographic bases of differentiation in Siberia and the Far East of expert assessments of a number of factors and conditions for inhibition and stimulation of the sociocultural and national-state unity of the peoples of modern Russia, Ukraine and Belarus are presented. The data were obtained during the first stage of the International Research Project «The main factors and conditions for the inhibition (stimulation) of the socio-cultural unification of the peoples of Russia, Ukraine and Belarus at the beginning of the 21st century», implemented under the auspices of the REC «Culture is the basis of the quality of education ...» of the International Fund for Slavic Writing and Culture, Institute of Art Education and Cultural Studies of RAO, Research Committee of Social Qualimetry of the Russian Sociological Association. They testify to the significant socio-demographic differences in assessments of experts characterizing the main factors and conditions of inhibition (stimulation) of the socio-cultural and national-state unity of the peoples of Russia, Ukraine and Belarus at the beginning of the 21st century.
Analysis of Building Information Modelling Application in Construction Project Management
Authors: Нечаева  , Nechaeva Irina
Published: July 2017

The paper presents the analysis of the current status of Building Information Modelling implementation in Russian construction industry. The case study approach was chosen to investigate 20 cases of BIM application by different participants of construction projects at different stages of the project and product life cycle. Particular benefits of BIM spread in industry are defined and pitfalls AEC companies may encounter in construction project management processes are revealed.
Parenteral nutrition: indications and safe management
Authors: Wyer Nicky
Published: July 2017

The aim of this article is to provide an overview of what parenteral nutrition (PN) is and when its use is required. It will describe the process of nutritional assessment, and considerations when choosing venous access. The different approaches to provision of PN solutions in hospital will be discussed. Catheter-related and metabolic complications can occur during delivery of PN; there will be a discussion of the different types of complications and how these can be avoided or minimised. Finally, the pivotal role of the nurse in the assessment and ongoing care of patients who require PN will be highlighted, including skills required to administer PN safely.
If you ‘Remember, Remember’ on 5th November it's too late!
Authors: Hargrave Claire
Published: July 2017

Owners commonly wait until the end of October before coming to the veterinary surgery with their sound-sensitive pet. Treatment can be much more effective if it is started earlier: summer is the best time to start talking with your clients and initiating preparations to treat their pet's sound sensitivity problem.
The growth of patience in children
Authors: Simms Margaret
Published: July 2017

Reviewing the foundation stage from a perspective of cultivating patience not products, will revitalise activity planning, reinvigorate environments and develop a child's unique and long-lasting virtue.
Moving with the weather
Authors: Rodgers Anne
Published: July 2017

Outdoor activity is essential for personal, emotional and physical development. Whether children live in a city, village, a rural setting or by the sea, they all need to be able to experience play outside.
Learning becomes a story
Authors: Parker Amy
Published: July 2017

Following on from our recent articles on Talk for Maths Mastery, we take a closer look at the process by examining a whole-class approach to building on the mathematical thinking in child-led interests.
In vitro Regeneration of Alstroemeria cv. ‘Balance’ by Indirect Organogenesis
Authors: Nazarian Hossein , Beigi Harchegani Maryam , Otroshy Mahmoud , Motamedi Ali
Published: July 2017

ABSTRACT: This study was designed in order to optimize the indirect organogenesis (during callus induction and regeneration) of Alstroemeria cv. ‘Balance’ through tissue culture technique in two phases; the first stage: callus induction by rhizome segments, leaf and nodal stem which in the start, callus formation media were examined using two types of auxins; 2,4-D and NAA and a cytokinin; BAP in four different experimentations. In the second stage, calli derived from rhizome segments and nodal stem explants were transferred to regeneration media. The results revealed that 2,4-D in combination with BAP in the rhizome segments and nodal stem explants were efficient as compared to NAA. The highest yield of callus formation was also obtained in the rhizome segments explants. According to the results, it can be suggested that NAA as auxin, does not have direct positive effect on cell division in Alstroemeria. The 2,4-D is toxic at high concentrations and may bring about cell death. Eventually, the composition of 0.5 mg/l NAA with 3 mg/l BAP and callus derived from nodal stem explants may be introduced as the best combination for regeneration. These results indicate the necessity of the BAP cytokinin presence for regeneration. In addition, the maximum length of the shoot was obtained from combination of BAP with nodal stem explants, without the presence of NAA.
Innovative Optimal Approach to Implement Fast Propagation Tissue Culture
Authors: Nazarian Hossein , Hossein Ghadimi Amir
Published: July 2017

ABSTRACT: In this study bulbetets of royal lily have been used as explants. The innovative approach is based on optimal placement and adventitious sprout induction and the adventitious sprout proliferation in special conditions. Then effects of different parts of scales and placement method, types and concentrations of cytokinin, different parts of bulbetet scales and placement method on adventitious sprout induction have been discussed. At the end the effects of plant growth regulators on induction and multiplication of bulbetet scales of royal lily have been studied. The results represents that the regeneration ability of outer layer scales of royal lily is better than the middle ones, which was better than the inner ones. The adaxial side of royal lily bulbetets in contact with medium upward can produce more and stronger adventitious sprouts than the adaxial side downward.
The Skeletal Characteristics of Patients With Buccal and Palatal Impacted Permanent Maxillary Canines in Ahvaz, Iran.
Authors: Mohammad Mousavi Seyed , hojjat Shakib Seyed , Raiespour Sara
Published: July 2017

ABSTRACT: The maxillary permanent canines are the second most common impacted teeth after the third molars. Nevertheless, the degree to which clinicians are aware of the risk of canine impaction in each skeletal pattern may help them prevent these impactions or manage them. The present study determined the skeletal characteristics of the patients with the buccal and palatal impacted permanent canines among Ahvaz populations.In a descriptive epidemiologic study, lateral cephalometric and panoramic radiographs of 110 patients with the permanent impacted canines (bilateral or unilateral) were collected from the Orthodontic Department and orthodontic offices in the city of Ahvaz. Using cephalometric and panoramic images, and by clinical evaluations, buccal and palatal impacted canines were diagnosed. Cephalometric analysis was done to determine the anterior-posterior parameters including the angle of maxilla to the skull base (SNA), the angle of the mandible to the skull base (SNB), SNA angle and SNB angle difference (ANB) and the indices to determine the vertical characteristics including the angle between the Frankfurt plane and mandibular plane (FMA); Anterior lower facial height index and Jaraback index was calculated. According to the data obtained, anterior- posterior and the vertical skeletal patterns were determined for the patients by gender. The frequency of different patterns was calculated and then reported. Among those patients who have buccal canine impactions, females with Cl II skeletal pattern and long-face had the most frequencies, whereas the males with the Cl II skeletal pattern and normal face and also the males with the Cl III skeletal pattern and three vertical patterns had the least prevalence. In patients with the maxillary palatal canine impactions, female population with the Cl I skeletal and short-face pattern had the most frequency and the subjects with Cl III skeletal pattern showed the least prevalence. What could be concluded is that various facial morphologies were observed in both male and female populations of Ahvaz having permanent buccal and palatal impacted maxillary canines.
Kajian Pengaruh Material Graphene pada kinerja Biosensor Berbasis Surface Plasmon Resonance (SPR) pada Deteksi Makanan Halal sebagai Pendukung Halal Research Center UIN Sunan Kalijaga Yogyakarta
Authors: Yanti Wida , Melati Asih
Published: July 2017

Halal foods and medicines are an absolute daily needs for the Muslim community in Indonesia. Therefore the authority institutions in indonesian goverment should ensure the availability of this. It is of course inseparable from the role of higher education through the development of its technology to develop halal detection of foods and drugs. This study is an effort to contribute to the Halal Research Center of UIN Sunan Kalijaga Yogyakarta through the biosensor development in halal detection foods and medicines based on biosensor SPR. This device using graphene materials to improve the detection sensitivity of pork gelatin material that is likely contained in foodstuffs and medicine. From analytical calculation and computation, enhancement of the SPR biosensor performance by involvement graphene it was shown through the ATR (Attenuated Total Reflectance) reflective curve. The result of this results was found the enhancement of the sensitivity 2,86 %.

Keyword: Surface Plasmon Resonance (SPR), Porcine Gelatin, Graphene, ATR
Marcas das Experiências Sociais e Interculturais de Estudantes em Mobilidade Internacional: dos laços de amizade aos “perrengues”
Authors: Medeiros Cintia Rodrigues de Oliveira , Andrade Antonia Darliane da Silva , Passos Janduhy Camilo
Published: July 2017

Das mudanças ocorridas quanto ao mercado de trabalho global, emerge a exigência por um perfil profissional com visão intercultural, entre outras características. Desde o início dos anos 2000, o governo brasileiro intensificou sua atuação nos programas de mobilidade estudantil de nível superior em âmbito internacional. No mesmo compasso, as universidades brasileiras, também, estimulam os estudantes à prática do intercâmbio, aderindo aos diversos programas de mobilidade nacional e internacional. Esta pesquisa teve como objetivo reunir e analisar experiências sociais e culturais de estudantes de administração da Universidade Federal de Uberlândia (UFU) relativas ao período vivido em mobilidade internacional. Para tanto, foram realizadas entrevistas semiestruturadas com oito estudantes do curso de Administração da UFU que participaram dos programas de Mobilidade Internacional nos últimos dois anos. Para a análise do corpus de pesquisa, foi utilizada a técnica de análise de conteúdo. Como resultado, foi identificado que as experiências sociais dos estudantes em mobilidade internacional são marcadas por laços de amizade, aventuras, conhecimento, fala negociada e “perrengues”.
Processo de ensino-aprendizagem e a interação de professores e alunos em um curso de graduação em Administração de Empresas
Authors: Beni Priscila Ferreira , Breno Felipe Rafael , Villela Lucas Moreira , Esteves Robson , Jones Graciela Dias Coelho , Forte Denis
Published: July 2017

Com o intuito de entender como acontece o processo de ensino-aprendizagem e a interação de professores e alunos em cursos de graduação em Administração de Empresas, este estudo buscou, por meio de uma pesquisa qualitativa, de caráter descritivo, feita em uma universidade particular da cidade de São Paulo, identificar os vários aspectos da interação de professor e aluno no processo de ensino-aprendizagem: o papel da discussão na construção da aprendizagem, o planejamento da disciplina e a interação do aprendizado dentro e fora da sala de aula, a participação dos professores e alunos no ambiente virtual de aprendizado, por meio do Moodle, e a avaliação do desempenho dos alunos. Os resultados demonstraram que, mesmo seguindo o conteúdo programático e atendendo às exigências da instituição e do Projeto Político-Pedagógico, os professores, em geral, possuem um bom relacionamento com as turmas e mostraram-se flexíveis com as demandas dos alunos. Em todas as observações, pôde-se verificar que os docentes tentaram promover um ambiente dinâmico e incentivador ao aluno.
COMMUNITY STRUCTURE OF CHAETODONTIDAE IN THE WEST OF BANDA SEA
Authors: Wibowo Kunto , Adrim Mohammad , Makatipu Petrus Christianus
Published: July 2017

Distribution and composition of Indonesian Chaetodontid species may vary among different locations. However, illegal fishing practices such as bombing and poisoning on reef ecosystems have significant contribution to environmental degradation and can change the community structure of fish especially that of Chatodontids that act as indicator species in in the given areas. Therefore, it is important to do periodic surveys to know the current condition and their changing. A study on community structure of Chaetodontidae has been conducted from July toAugust 2011 on coral reef ecosystems of the Banda Sea and its adjacent waters including Banggai, Kendari, and Lamalera Islands. Scuba equipment was used and underwater visual census method was applied for collecting the data at 21 stations. A total of 1399 individual Chaetodontid fishes was observed, belonging to thirty species and seven genera, i.e. Chaetodon (20 species), Heniochus (4 species), Forcipiger (2 species), Chelmon (1 species), Coradion (1 species), Hemitaurichthys (1 species), and Parachaetodon (1 species). Chaetodon kleinii was the most dominant species in the Banggai (74,38%) and Lamalera (71,71%). Kendari was characterized by the presence of C. octofasciatus that contributed 55,20%. There were two dominant groups of Chaetodontidae based on the feeding guild. Facultative coral feeder was the most abundance in Banggai and Lamalera, while the most commonChaetodontidae in Kendari belonged to obligate coral feeder. Chaetodontid diversity in Banggai was the lowest compared to that of in other studied areas. Anthropogenic pressure may become a major factor causing the low diversity and studied species richness in the coral reef ecosystem of Banggai waters.
RECENT BLOOMING OF PYRODINIUM BAHAMENSE VAR. COMPRESSUM IN AMBON BAY, EASTERN INDONESIA
Authors: Likumahua Sem
Published: July 2017

In Indonesia, Pyrodinium bahamense var. compressum was first recorded in Kao Bay in 1994. In 1996 the illness of more than 30 people and the death of 3 children after consuming shellfish from Ambon Bay was reported. Until the shellfish poisoning cases was reported, occurrences and blooms of P. bahamense, neither its toxic events had never been known in Ambon Bay. It has generated monitoring on the species occurrence which has been carried out since 2008. The bloom of P. bahamense was detected in July 2012. During the bloom event, concentrationsof phosphate, nitrate and dissolved oxygen were measured. Vertical profiles of temperature, salinity, turbidity and chlorophyll a were also measured during the red tide. Cells of P. bahamense, the PSP responsible species, were recorded abundant up to 2,496 cells/ml when red-brown water discoloration was observed in Ambon Bay. After the toxic red tide, human illness of 7 people due to shellfish consumption was also reported. In addition, the bloom event has damaged aquaculture products, due to mass mortality of cultured fish in inner Ambon Bay.
HABITAT HEALTH OF ILOILO RIVER - INSIGHTS FROM A STUDY ON BENTHIC COMMUNITY STRUCTURE
Authors: Palla Rocille Quilantang , Campos Wilfredo Lopez , Campos Annabelle Del Norte-
Published: July 2017

In west central Philippines, the monitoring of aquatic systems traditionally focused on dissolved oxygen values and biological oxygen demand, e.g. monitoring by the Environmental Monitoring Bureau around Panay Island. However, single or two factors are considered to be insufficient to assess habitat health precisely. In this paper, we investigated a benthic community and xamined their implications to habitat health of the Iloilo River. According to a prior benthic survey, warning signs pertaining to biotic, abiotic and community factors have been detected. The disturbed onditions in Iloilo River can be attributed to 3 factors; 1) its inherent topography, where bends serve as sinks for materials; 2) the lack of vigorous water exchange that promotes deposition and hinders complete flushing; and 3) the manner of utilization of the river by the local people. We thus concluded that: 1) monitoring for water parameters only is not enough to get a clear picture of habitat health; and 2) proposed that biotic components should be included for monitoring aquatic system.
SUBMARINE GROUNDWATER DISCHARGE MEASUREMENT ON THE SANDY UNCONFINED AQUIFER AT THE CARNAVAL BEACH, ANCOL (JAKARTA BAY)
Authors: Bakti Hendra , Lubis Rachmat Fajar , Delinom Robert M. , Taniguchi Makoto
Published: July 2017

Submarine groundwater discharge (SGD) is defined as all direct discharge of subsurface fluids into coastal zone. Components of SGD consist of fresh submarine groundwater discharge and the recirculated saline seawater discharge. SGD could act as a pathway for the transport of anthropogenic contaminants and nutrients to coastal waters. Measurement SGD at Carnaval Beach, Ancol, Jakarta was focussed on unconfined groundwater system. The method of quantified used automatic seepage meter for measured of SGD and installed conductivity temperature depth. The average SGD rate was 0.21 mm/min on March 20-31, 2009 consist of 19.05% fresh water, 80.95% recirculated seawater. April 1-23, 2009, the average SGD rate was 0.81 ml/min which consisted of 16.04% fresh water, 83.96% recirculated seawater. SGD fluctuation was opposite with the tide. As a result, submarine groundwater discharge at Jakarta coastal area was defined and can be measured to quantify.
Análise de sensibilidade em hidrogramas de cheias máximas obtidos pelo método do SCS em uma bacia urbana
Authors: Fernandes Renato De Oliveira , Costa Celme Torres Ferreira da , Studart Ticiana Marinho de Carvalho
Published: July 2017

A estimativas de vazão máxima de escoamento superficial são necessárias para o projeto de obras hidráulicas e modelagem hidrológica das águas subterrâneas em bacias urbanas e rurais. A dificuldade em aplicar os procedimentos disponíveis para calcular a variação do escoamento superficial com o tempo e de seu valor máximo está na escolha do método. Dessa forma, a investigação de um método que produza estimativas confiáveis da vazão máxima e do hidrograma de escoamento superficial é de grande interesse, principalmente considerando uma área de estudo localizada em uma região cujo abastecimento é quase exclusivamente subterrâneo, estudos desse tipo se apresentam com significativa relevância para os dados de recarga do aquífero. O trabalho teve como objetivo avaliar a sensibilidade dos hidrogramas de cheias máximas obtidos pelo método do SCS (Soil Conservation Service) a variação do CN (Número da Curva) e ao tempo de concentração em uma microbacia urbana localizada no município de Juazeiro do Norte/CE. Foram simulados 186 hidrogramas de vazões máximas a partir de seis cenários de uso e ocupação do solo e da variação do tempo de concentração com aplicação de sete equações para obtenção do tempo de concentração. Os resultados indicaram grande dependência na forma dos hidrogramas de vazões máximas obtidas pelo método do SCS ao valor do tempo de concentração e ao CN. Em adicional, o estudo revelou que a cheia máxima na bacia analisada é mais sensível as alterações do CN nas condições de pequenos tempos de concentrações.
Análise da potabilidade das águas dos poços rasos escavados da comunidade do Taim em São Luís – Maranhão
Authors: Neto Wallace Ribeiro Nunes , Pereira Dagolberto Calazans Araujo , Santos Jessflan Rafael Nascimento , Monteiro Andrea Souza , Villis Paulo Cesar Mendes , Fillho Victor Elias Mouchrek
Published: July 2017

Qualidade de vida e a busca do bem-estar unificado com a saúde do ser humano, vem sendo um tema em destaque, tendo a água como um dos indicadores cruciais para tal objetivo. Doenças de veiculação hídrica ainda é um desafio para o Ministério da Saúde, onde o meio rural é uma região vulnerável e propicia para o aparecimento das mesmas. Desta forma, é de suma importância as análises de potabilidade para o monitoramento, que proporciona avaliar a qualidade e riscos, da saúde de uma população. O objetivo deste trabalho foi avaliar a potabilidade da água da comunidade do Taim no ano de 2013 a 2014, envolvendo padrões físico-químicos e microbiológicos através do método: Standand Methods for the Examination of Water & Wastewater, 21ª ed., 2005 do Ministério da Saúde onde os resultados foram comparados com parâmetros (Portaria MS Nº 2.914/2011). Alguns padrões físico-químicos apresentaram variação de acordo com a época a média da dureza da agua variou de 3,30 a 13,66 mg/L, bem como a alcalinidade, cujos valores variaram de 4,46 a 19,55 mg/L. O pH se encontrava entre as faixas de 5,17 a 5,66 mg/L., fora dos padrões estabelecidos para agua potável. Em adição, observou-se que as amostras apresentavam valores de Escherichia coli fora do estabelecido pela legislação (Portaria Nº 2914), Estas analises indicaram de uma maneira geral que a agua dos poços avaliados seria impropria para o consumo humano.
Therapeutic alliance in face-to-face and online counseling: Opinions of counselor candidates
Yüz yüze ve çevrimiçi psikolojik danışmada terapötik işbirliği: Psikolojik danışman adaylarının görüşleri
Authors: Zeren Şerife Gonca
Published: July 2017

The aim of this study is to examine how counselor candidates view therapeutic alliance within the frame of traditional face-to-face counseling and online counseling. The study was conducted with the participation of 11 volunteering counselor candidates (eight female and three male) in the fourth year of their Guidance and Psychological Counseling undergraduate program at a public university in Turkey. Results obtained through content analysis indicated that the counselor candidates were largely able to cooperate with their clients in setting goals, in working towards these goals and in solving problems, and that the counselor candidates formed a personal connection with the clients. However, it was also observed that online counseling led to problems in building cooperation to achieve goals, and in allowing the counselor and client to understand one another. ÖzetBu çalışmanın konusu, geleneksel yüz yüze psikolojik danışma ile çevrimiçi psikolojik danışma sürecindeki terapötik işbirliğini psikolojik danışman adaylarının nasıl değerlendirdiğidir. Bu çalışmaya Türkiye’de bir devlet üniversitesinde, Rehberlik ve Psikolojik Danışma lisans programı son sınıfta okuyan 11 (sekiz kadın ve üç erkek) gönüllü psikolojik danışman adayı katılmıştır. Yapılan içerik analizinin sonucunda, psikolojik danışman adaylarının; danışanları ile amaçları belirlemede, bu amaçlara ulaşmaya çalışmada, danışanların sorunlarının çözümünde büyük oranda işbirliği sağladıkları ve danışanları ile aralarında kişisel bir bağın oluştuğu bulgularına ulaşılmıştır. Ancak, çevrimiçi danışmada amaçlara ulaşmada işbirliği ve danışanla psikolojik danışman adayının birbirini anlamalarında güçlük yaşandığı sonucuna varılmıştır.
Impact of heated waters on water quality and macroinvertebrate community in the Narew River (Poland)
Authors: Krolak Elzbieta , Lewandowski Krzysztof , Kasprzykowski Zbigniew
Published: July 2017

The effect of heated waters from coal-burning power stations on the water parameters and the occurrence of macroinvertebrates depends on the individual characteristics of the river to which the heated waters are discharged. The objective of the study was to assess the impact of heated water from the Ostrołęka Power Station on selected water properties and the macroinvertebrate community in the Narew River. Samples were collected in years: 2013-2016 along two river stretches: upstream and downstream of the canal. The water temperature was higher and the oxygen concentrations were lower at the downstream sites compared to the upstream sites of the canal. The values of conductivity, concentrations of nitrates, phosphates, chlorides and calcium were similar at the sampling sites. A total of 33 families of macrozoobenthos were found. The numbers of families were positively correlated with the temperature and conductivity and negatively correlated with oxygen. The heated waters were found to have no effect on the Shannon-Wiener diversity index. The inflow of heated waters increased the percentage of Gammaridae, represented by speciesDikerogammarus haemobaphes(Eichwald, 1841) and decreased the percentage of Chironomidae. The presence of the thermophilous bivalveSinanodonta woodiana(Lea, 1934) was noted downstream of the canal.
Classification of coal seam outburst hazards and evaluation of the importance of influencing factors
Authors: Shi Xianzhi , Song Dazhao , Qian Ziwei
Published: July 2017

Coal and gas outbursts are the result of several geological factors related to coal seam gas (coal seam gas pressure

To classify the outburst hazard level of a coal seam by means of statistical methods, this study considered the geological parameters of coal seam gas and statistical data on the amount of material involved in coal outbursts. Through multivariate regression analysis, a multivariate regression equation between the outburst coal quantity and

Using a significance evaluation of the aforementioned factors, the relative contributions of the gas-related geological parameters to the outburst hazard level of a coal seam were found to follow the order

This work provides a scientific basis for evaluating the outburst hazard level of a coal seam and adopting feasible and economical outburst-prevention measures.
Modelling Mixed Types of Outcomes in Additive Genetic Models
Authors: Hugo Bonat Wagner
Published: July 2017

We present a general statistical modelling framework for handling multivariate mixed types of outcomes in the context of quantitative genetic analysis. The models are based on the multivariate covariance generalized linear models, where the matrix linear predictor is composed of an identity matrix combined with a relatedness matrix defined by a pedigree, representing the environmental and genetic components, respectively. We also propose a new index of heritability for non-Gaussian data. A case study on house sparrow (Passer domesticus) population with continuous, binomial and count outcomes is employed to motivate the new model. Simulation of multivariate marginal models is not trivial, thus we adapt the NORTA (Normal to anything) algorithm for simulation of multivariate covariance generalized linear models in the context of genetic data analysis. A simulation study is presented to assess the asymptotic properties of the estimating function estimators for the correlation between outcomes and the new heritability index parameters. The data set and R code are available in the supplementary material.
Linguistic hypercorrectness versus colloquial use in Latin at first century BC and afterwards
Authors: Calboli Gualtiero
Published: July 2017

I discussed a passage in the
Edges of Diplomacy: Literary Representations of the (Honorary) Consul and the Public-Private Divide in Diplomatic Studies
Authors: Scott-Smith Giles
Published: July 2017

This article investigates the relevance of consular positions, and particularly the honorary consul, through their representations in modern literature and the arts. Although the honorary consul’s official status is codified in the Vienna Convention on Consular Relations of 1963, this document clearly identifies the limits to diplomatic immunity for this position, such that the honorary consul occupies a hybrid space on the boundary between the public and the private. This hybridity opens up the possibility for ambiguity in terms of conflicts of interest and divided loyalties. Acknowledging this hybridity requires re-examining the position of honorary consul beyond formal descriptions in mainstream diplomatic studies which are often evasive on the position’s actual status. In contrast, their representation in modern literature and the arts offers a more candid insight into the ontology and practice of consuls and consular work. As a result, the article makes the claim that the honorary consul illustrates that the public/private divide in contemporary diplomacy is less stable than is generally presented, and that the rise of private entities as diplomatic actors is therefore more a question of intensity than the emergence of something entirely new.
Beco como lugar de intervenção para acesso às sensibilidades urbanas e suas memórias
Authors: Santos Nádia Maria Weber , Gransotto Luciana
Published: July 2017

Neste artigo pensa-se o beco como lugar de representação simbólica da cidade e, também, como espaço para intervenções urbanas, a partir de um conjunto de significações que fazem da sua invisibilidade material, fonte para proposição de novas leituras, narrativas e sensibilidades. Em uma perspectiva que articula os campos do turismo cultural e da história das sensibilidades, o texto propõe refletir as experiências do indivíduo no espaço, como meio de perceber o sentido do beco, tal como ele é dado pela construção dos imaginários urbanos ao longo do tempo, assim como por uma nova categoria de interpretação que aqui se sugere, a realização de um itinerário histórico-cultural. Os antigos becos do final do século XIX de Porto Alegre são trazidos para esse contexto como referência de espaço que não resistiu às transformações da modernidade, mas que ainda abarcam, significativamente, traços e conteúdos históricos que estão envolvidos nas discussões contemporâneas sobre territórios urbanos excluídos, presentes nas memórias da cidade.
En el camino: Misioneros, recorridos y paisajes (Esteco, s. XVI-XVII; Tierra del Fuego, s. XIX-XX)
Authors: Salerno Melisa A. , MARSCHOFF María
Published: July 2017

A ação missionária tradicionalmenteenvolveua proclamação do Evangelho entre aqueles que o desconheciam. Nosso trabalho considera dois estudos de caso envolvendo experiências missionárias, temporal e espacialmente diferentes. A primeira correspondeu à obra dos jesuítas em Esteco, entre os séculos XVI e XVII; e a segunda, á obra dos salesianos na Tierra del Fuego, no final do século XIX e no início do XX. Neste trabalho consideramos a dimensão espacial da ação missionária, considerando a relação entre os religiosos e as paisagens. Em particular, destaca-se a importância de estudar paisagensvividas e percorridas, caracterizadas pela sua dinâmica e mutabilidade. Nosso objetivo é analisar os "paisagens em movimento", discutindo a diversidade de caminhos seguidos, a materialidade das paisagens físicas e habitadas, e as práticas e experiências dos sacerdotes. Os resultados servem não somente para discutir certas particularidades dos estudos de caso, mas também para consideraro possível impacto da integração do movimento em o estudo das paisagens e o mundo colonial em arqueologia.
Objeto, memória e afeto: uma reflexão
Authors: Nery Olivia Silva
Published: July 2017

Sejam objetos banais ou relíquias,eles podem desempenhar papéis importantes na construção da identidade, personalidade, e com vínculos memoriais dos sujeitos. Possuem a capacidade de serem evocadores memoriais e narradores de histórias. Nesse sentido, esse ensaio apresenta uma reflexão sobre o poder memorial e afetivo que alguns objetos possuem na vida dos indivíduos. Nesse caso, apresentamos aqui os objetos que pertenceram a Lyuba Duprat (1900-1994), que lecionou durante décadas a língua francesa na cidade do Rio Grande, Rio Grande do Sul.
Consequences of mitotic slippage for antimicrotubule drug therapy
Authors: Cheng Bing , Crasta Karen
Published: July 2017

Antimicrotubule agents are commonly utilised as front-line therapies against several malignancies, either by themselves or as combination therapies. Cell-based studies have pinpointed the anti-proliferative basis of action to be a consequence of perturbation of microtubule dynamics leading to sustained activation of the spindle assembly checkpoint, prolonged mitotic arrest and mitotic cell death. However, depending on the biological context and cell type, cells may take an alternative route besides mitotic cell death via a process known as mitotic slippage. Here, mitotically arrested cells ‘slip’ to the next interphase without undergoing proper chromosome segregation and cytokinesis. These post-slippage cells in turn have two main cell fates, either cell death or a G1 arrest ensuing in senescence. In this review, we take a look at the factors determining mitotic cell death vs mitotic slippage, post-slippage cell fates and accompanying features, and their consequences for antimicrotubule drug treatment outcomes.
THE QUANTITATIVE AND QUALITATIVE ANALYSIS OF PUBLIC ADMINISTRATION REFORMS IN POST-COMMUNIST COUNTRIES
Authors: Nakrošis Vitalis
Published: July 2017

In this article we describe the adoption and execution of public administration reforms in Central and Eastern Europe between 2008 and 2013, as well as examine whether post-communist countries differ from other groups of European countries in terms of the substance of reforms and their implementation process. Instead of following popular Western administrative theoretical frames, we adopt the policy process approach. We focus on the role of policy actors during reform policymaking and implementation at the level of policy subsystems. More specifically, we employ the rational-comprehensive and garbage can perspectives to understand the reform processes in the post-communist region. Our research is based on the statistical analysis of survey data and two case studies of reforms initiated by the 2008-2012 Lithuanian government. The article concludes that countries in Central and Eastern Europe share some common characteristics: they focused on the issues of civil service and public or administrative services, their reform policy was often formulated on a top-down basis, and its execution often lacked adequate capacities. Despite a rational reform façade in these countries, the implementation of governance change appears to be quite erratic, as anticipated in the garbage can perspective. This can have negative consequences on the effectiveness of public policy, continuing to generate public distrust in post-communist state institutions.