bluuebunny/crossref_metadata_2025 huggingface dataset:
Simulation study of reactive distillation process for synthesis of dimethyl maleate
Authors: Wahab Abdul , Xu Yanhong , Zhao Jigang
Published: December 2023

Conventional dimethyl maleate (DMM) synthesis relies on the use of sulfuric acid as a catalyst which requires water washing and produces a large amount of wastewater that harms the environment. The use of this method is expensive since it involves numerous processes such as neutralization of sulfuric acid, washing with water, distillation etc. and the yield of dimethyl maleate is not very high. Reactive distillation integrates the two important industrial processes such as reaction and distillation into a single unit which shortens the overall process, reduces capital and operating costs, and maintains the reaction in a forward direction to enhance the conversion of maleic anhydride by continuously removing of the products. In this work, simulation study based on experimental investigation of reactive distillation process for the synthesis of dimethyl maleate was carried out using Aspen Plus V11. DZH strong cation exchange resin was used as catalyst for esterification reaction of maleic anhydride with methanol. A reactive section of column was packed with Katapak SP type packing loaded with DZH catalyst while non-reactive sections consist of wire gauze packing. In order to describe a reactive distillation process for synthesis of dimethyl maleate, RAD-FRAC equilibrium stage model was employed. The NRTL activity model and RK equation of state model were selected to describe vapor-liquid equilibrium of the system. The reliability of the developed simulated model was verified by validating the simulation results with the experimental ones. The effect of various design and operating parameters on the conversion of maleic anhydride and purity of dimethyl maleate has been studied. It was found that the optimal condition for RD, were as follow: total number of theoretical stages 17, rectifying stages 3, reactive stages 7, stripping stages 5, reflux ratio 0.25, operating pressure 0.1 MPa, reboiler duty 250 Cal/Sec, feed mole ratio 1:5. Under optimized condition the water formed as a results of esterification reaction was constantly removed from the reactive section of the column to maintain reaction balance, the conversion of maleic anhydride was 99.95 %, purity of dimethyl maleate achieved was 0.997 and the reactive distillation process was feasible to produce dimethyl maleate without any wastewater.
Incorporation of oyster mushroom powder and pearl millet flour improves the nutritional quality and glycemic response of Indian flatbread
Authors: Dhillon Gurpreet Kaur , Mahajan Monika , Kour Amardeep , Kaur Kamaljit
Published: December 2023

The purpose of present study is to develop a nutritionally enriched and low GI (glycemic index) Indian flatbread using nutritionally balanced crops. To achieve this goal, whole wheat flour was supplemented with different levels of oyster mushroom powder (OMP) – 5 %, 10 %, 15 %, and 20 %, along with pearl millet flour (PMF) – 10 %, 20 %, 30 %, and 40 %, resulting in a range of formulations for the study. The prepared formulations were evaluated for their chemical, physical, pasting, texture, predicted GI, resistant starch and sensory properties along with color analysis. The protein and fiber content in formulated flatbread increased with increase in percentage of OMP and PMF from 5–20 % and 10–40 % respectively. The pasting properties showed a significant (p < 0.05) reduction in peak, breakdown, trough, final and setback viscosities of composite flour. However, no significant effect on dough handling was observed due to change in pasting behaviour. Furthermore, in vitro protein digestion studies (IVPD%) indicated improved protein quality in formulated flatbread. The whole wheat flour supplementation has also reduced starch hydrolysis rate by decreasing composite flatbread’s predicted glycemic response (pGI) from 82 in control wheat bread to 61–50 in formulated flatbread. Colour attributes of enriched flatbread showed a darker colour than control, however, it was preferred by the panellists at OMP (15 %) and PMF (30 %) substitution by obtaining an overall acceptability score of 7.3 out of 9.0. Practical application: The present study will be very helpful for a diabetic patient to take the best composition of flatbread in their diet to effectively manage their rise in blood glucose level.
A Change in the Weather: Understanding Public Usage of Weather Apps
Authors: Vaughn Cole , Sherman-Morris Kathleen , Brown Michael
Published: December 2023

Weather information can now be accessed through a variety of different media. This study used a survey to determine if the weather app was the primary source for weather information in the United States and whether this was related to age and other personal characteristics. More than 75% of the sample reported using a weather app for general forecast information. In cases of severe weather, weather apps and websites were reported to be the top two primary sources. While younger demographics had more weather app users than older demographics, the weather app was still the most popular source among the older groups. The most popular apps were the pre-downloaded app on a phone, The Weather Channel’s app, and the AccuWeather app. Participants who chose to use an app other than the pre-downloaded one reported higher self-perceived knowledge about, and interest in, weather. In addition, 80% of respondents reported getting severe weather notifications on their phone. The study’s survey sample was heavily skewed toward a younger population and may not be generalizable to all socioeconomic demographics. Considering previous research, these results indicate a shift in the predominant forecast sources used by the public over the last 10–15 yr. Consequently, it has resulted in a widespread transfer of responsibility for interpreting and explaining the forecast. A majority of the public—untrained in meteorology—is now interpreting the forecast on their own without the help of a broadcast meteorologist as would be present in a television forecast, making the forecast open to misinterpretation and false expectation. This study calls for continued research to combat misinterpretation and to enhance weather apps and mobile notifications with more personalized information that can aid weather-related decision making to make weather apps a strong leader in forecast messaging.
Information Technologies and Digital Transformation in the System of Adaptive Development of Retail Enterprises
Authors:   State University of Biotechnology, Hrosul Viktoriia , Shinkarenko Ivan ,   State University of Biotechnology
Published: December 2023

The modern information space of adaptive development of retail enterprises is characterized and the distinctive properties of information technologies are defined. Digital technologies are systematized and their functional purpose is defined. The general advantages of data analytics are formulated and the advantages of modern video analytics systems, chatbots, Internet of Things (IoT), RFID tags in the organization of retail trade enterprises are characterized. The need for a situational approach to digital changes is argued. A model of the formation of a comprehensive mechanism for the readiness of a retail trade enterprise for digital transformation has been developed. Digital competencies of personnel are considered as key criteria for establishing the level of readiness for digital transformation of business processes at various levels in the conditions of a highly dynamic business environment. The list of DigComp 2.0 digital competencies was considered. Two groups of digital competencies have been formed: basic and special for solving specific tasks of adaptive development of a retail enterprise.
Theoretical and Applied Aspects of Socio-Economic Support for the Development of Creative Enterprises
Authors:   Odesа Polytechnic National University, Korіavchenkovа Tatiana
Published: December 2023

A critical analysis of thematic approaches to ensuring the activity / development of modern enterprises was carried out. The priority directions for their improvement in dynamic and unpredictable economic conditions have been determined and the necessity of their integration in the processes of ensuring the development of business entities has been proven. A scientific approach to ensuring development has been developed, which takes into account the specifics of creative business and is aimed at achieving maximum compliance of the internal system characteristics of creative enterprises with the current and future conditions of the space of their life activities. For the implementation of the proposed approach, an appropriate organizational and economic mechanism of implementation is substantiated based on the key parameters of provision: creative leadership, digitalization, organizational leadership.
Assessment of Losses of City Parks in the Context of Post-War Reconstruction of Cities of Ukraine and Sustainable Development
Authors:   Institute of Market and Economic&Ecological Research of the National Academy of Sciences of Ukraine, Vernihorova Nataliia
Published: December 2023

In order to restore the affected cities into a more comfortable habitat, and special attention should be paid to city parks. The reproduction of public spaces allows to ensure the social activity of the locals and the cultural development of society. In order to make the most effective decisions to restore parks, it is urgent to develop methods of evaluation of parks losses as a result of military events. Therefore, the purpose of this article is to analyze the existing methods of evaluation of losses with green planting, and the development and proposal of author's methods of calculations of losses of parks. Using the methods of analysis and synthesis, the assessment of modern regulatory documents for the evaluation of green spaces was carried out, and on the basis of established taxes for green spaces for cities, the formulas for calculations of losses were proposed. Simplified parking rates based on point indicators, which can be used as a simplified version of preventive analysis, is also proposed. The practical importance of the article is to expand the losses of parks that can be used in the evaluation of parks by utility companies of the parking space and park administrations.
Theoretical and Methodological Principles of Intellectual Property Management
Authors:   National Technical University ", Maslak Maria ,   Kharkiv Polytechnic Institute", Pererva Petro ,   National Technical University "Kharkiv Polytechnic Institute", Higher School of Labour Safety Management − WSZOP
Published: December 2023

The article examines the concept and essence of intellectual property management, as well as models, methods and tools of intellectual property management at industrial enterprises. According to the results of the research, methodological and methodical approaches to the management of the processes of creation and introduction into economic circulation of intellectual property objects at enterprises of the real sector of the economy during the life cycle of intellectual products have been provided. The scientific novelty of the study is presented in the form of updating and multiplying scientific knowledge and methodical recommendations regarding the implementation of the intellectual property management system at the industrial enterprise. Based on the principles of the process-system approach and modeling methods, the authors proposed a model and methodological toolkit for the implementation of the intellectual property system at the enterprise level. The system, in turn, is presented as a process with the selection of stages and a description of the content of each stage. The proposed model can be used in the practical activity of an industrial enterprise.
Methodical Bases of Evaluation the Stability of Reproduction Development of Agro-Food Markets
Authors:   State Institution ", Nikishyna Oksana ,   Institute of Market and Economic & Ecological Research of National Academy of Sciences of Ukraine"
Published: December 2023

The article is developed methodical recommendations for evaluating the reproduction development of agro-food markets, which are a component of methodical provision of comprehensive evaluation of commodity markets on the basis of stability (resilience). Indicator systems for evaluating the dynamics of reproduction processes in the sectors of commodity markets, as well as the dynamics, structure and redistribution of added value in the markets, which included the author's indicators, were proposed, allowing to deepen the analysis of market reproduction processes in the sectoral dimension. On the basis of methodical recommendations, an empirical study of food security indicators of Ukraine, dynamics of export-import flows of agri-food products, sectoral and resource structure of gross added value was conducted, which made it possible to determine trends in the development of agri-food markets during the war period, as well as distinctive features of the instability of the economy.
Management Features of the South-Korean Corporations in the Digital Paradigm of Development
Authors:   Kyiv National Economic University named after Vadym Hetman, Petko Stanislav
Published: December 2023

The article is devoted to investigation of the formation features and evolution of the South-Korean organizations management system. It was determined, that the South-Korean management system formation occurred in the parallel with the rapid economy industrialization, which was based on the Japanese management model and Confucian ideas. During the historical excursion, the period of economic reforms implementation was analyzed. It was proved, that the group collectivism played an important role in management in the first stage of the South-Korean economy industrialization. It was noted, that for the South-Korean transnational business-structures of the full innovation cycle, collectivism was a restrictive factor in the transition to the innovative businesses, which requires creative approaches in management. On the example of the service-oriented Naver Corporation, it was proved, that the South-Korean technological business structures of a «new type» are using only Western approaches in the Corporate Governance, which based on the flexible management, transparence of management-decisions making, creativity, personal values of the managers and ESGconcept.
New Art Therapy Technology – Quilling
Authors: Iskakova Zhansaya , Kassymova Roza , Zhamalova Tansholpan , Chalimbayeva Anel , Utegenova Kamilya
Published: December 2023

This research work aims to study the main features of quilling technology in art therapy, as well as its impact on group and individual consciousness. The study’s methodological approach was the search and theoretical analysis of thematic literature studying the quilling technique of art therapy, as well as art therapy in general. In this article, the theoretical method, the method of comparative analysis, as well as the method of pedagogical experiment were used. As a result of the scientific research, the technology of art therapy as such was analysed, and its components and influence on children and adults were studied. Also, after performing a pedagogical experiment, the influence of quilling technology on students of Al-Farabi Kazakh National University was studied, and the results were analysed. According to the results of the pedagogical experiment, quilling art has a positive effect on individuals, as well as on the general mood of the group, and the use of the quilling technique as an art-therapeutic tool brings positive changes to the psychosomatics of an individual and a group in general. This research work is of practical importance in the study of the art of quilling as an art-therapeutic method in the development of fine motor skills in the hands of adults and children, as well as the improvement of the psychological state after psychological traumas of various kinds.
Life Gets Even More Beautiful, During Extended 90 + Minutes
Authors: KOCAKARIN Engin
Published: December 2023

In the 2022 Qatar World Cup, FIFA increased additional time by adding every moment when the ball isn’t played to the play time as an allowance for time lost. This also increased the number of goals scored during additional time. This research studies the impact of goals scored during additional time on match results caused by this extension in the second half of matches in Turkish Male Football Super League. Quantitative and qualitative methods were used. 250 matches played on weeks 1st–30th of 2022–2023 season of Turkish Spor Toto Male Football Super League were analyzed with document analysis, a qualitative research method. The matches, results, additional time, and goals scored during additional time were recorded. Then matches were separated into two equal-numbered groups including before and after the 2022 Qatar World Cup. The 125 matches on weeks 1st–14th and the 125 matches on weeks 14th–30th were analyzed for the number of total goals, total additional time, and the number of total goals scored during additional time with causal-comparative research model as a quantitative research method. In this research, Frequencies Analysis chosen from statistical analyses, Paired Sample t-Test and Pearson Correlation Analysis were used. According to the results, especially after the 2022 Qatar World Cup, the matches aren’t only ninety minutes for footballers any more. The matches may last up to two hours with extended additional time. As a conclusion of this research, teams can be suggested to consider this situation and properly organize training plans, programs.
On the Dirac-like equation in 7-component space-time and generalized Clifford-Dirac algebra
Authors: Simulik V.M.
Published: December 2023

The generalized Dirac equation related to 7-component space-time with one time coordinate and six space coordinates has been introduced. Three 8-component Dirac equations have been derived from the same 256-dimensional Clifford-Dirac matrix algebra. Corresponding Clifford-Dirac algebra is considered in the Pauli-Dirac representation of $8 \times 8$ gamma matrices. It is proved that this matrix algebra over the field of real numbers has 256-dimensional basis and it is isomorphic to geometric $\textit{C}\ell^{\texttt{R}}$(1,7) algebra. The corresponding gamma matrix representation of 45-dimensional $\mathrm{SO}(1,9)$ algebra is derived and the way of its generalization to the $\mathrm{SO}(m,n)$ algebra is demonstrated. The Klein-Gordon equation in 7-component space-time is considered as well. The way of corresponding consideration of the Maxwell equations and of equations for an arbitrary spin is indicated.
Derivations of Mackey algebras
Authors: Bezushchak O.
Published: December 2023

We describe derivations of finitary Mackey algebras over fields of characteristics not equal to $2.$ We prove that an arbitrary derivation of an associative finitary Mackey algebra or one of the Lie algebras $\mathfrak{sl}_{\infty}(V|W)$, $\mathfrak{o}_{\infty}(f)$ is an adjoint operator of an element in the corresponding Mackey algebra. It provides description of derivations of all algebras in the Baranov-Strade classification of finitary simple Lie algebras. The proof is based on N. Jacobson's result on derivations of associative algebras of linear transformations of an infinite-dimensional vector space and the results on Herstein's conjectures.
On the domain of convergence of general Dirichlet series with complex exponents
Authors: Kuryliak M.R. , Skaskiv O.B.
Published: December 2023

Let $(\lambda_n)$ be a sequence of the pairwise distinct complex numbers. For a formal Dirichlet series $F(z)=\sum\limits_{n=0}^{+\infty} a_ne^{z\lambda_n}$, $z\in\mathbb{C}$, we denote $G_{\mu}(F),$ $G_{c}(F),$ $G_{a}(F)$ the domains of the existence, of the convergence and of the absolute convergence of maximal term $\mu(z,F)=\max\big\{|a_n|e^{\Re(z\lambda_n)} : n\geq 0\big\}$, respectively. It is well known that $G_\mu(F), G_a(F)$ are convex domains.

Let us denote $\mathcal{N}_1(z):=\{n : \Re(z\lambda_n)>0\}$, $\mathcal{N}_2(z):=\{n : \Re(z\lambda_n)<0\}$ and \[\alpha^{(1)}(\theta) :=\varliminf\limits_{\genfrac{}{}{0pt}{2}{n\to +\infty}{n\in\mathcal{N}_1(e^{i\theta})}}\frac{-\ln|a_n|}{\Re(e^{i\theta}\lambda_n)},\qquad \alpha^{(2)}(\theta) :=\varlimsup\limits_{\genfrac{}{}{0pt}{2}{n\to +\infty}{n\in\mathcal{N}_2(e^{i\theta})}}\frac{-\ln|a_n|}{\Re(e^{i\theta}\lambda_n)}.\] Assume that $a_n\to 0$ as $n\to +\infty$. In the article, we prove the following statements.

$1)$ If $\alpha^{(2)}(\theta)<\alpha^{(1)}(\theta)$ for some $\theta\in [0,\pi)$ then \[\big\{te^{i\theta} : t\in (\alpha^{(2)}(\theta),\alpha^{(1)}(\theta))\big\}\subset G_\mu(F)\] as well as \[\big\{te^{i\theta} : t\in (-\infty,\alpha^{(2)}(\theta))\cup (\alpha^{(1)}(\theta),+\infty)\big\}\cap G_\mu(F)=\emptyset.\]

$2)$ $G_\mu(F)=\bigcup\limits_{\theta\in [0,\pi)}\{z=te^{i\theta} : t\in (\alpha^{(2)}(\theta),\alpha^{(1)}(\theta))\}.$

$3)$ If $h:=\varliminf\limits_{n\to +\infty}\frac{-\ln |a_n|}{\ln n}\in (1,+\infty)$, then \[\Big(\frac{h}{h-1}\cdot G_a(F)\Big)\supset G_\mu(F)\supset G_c(F).\] If $h=+\infty$ then $G_a(F)=G_c(F)=G_\mu(F)$, therefore $G_c(F)$ is also a convex domain.
Pulmonary aspergillosis: infection, diagnosis and treatment
Authors: Singh Neha , Bange Khushboo
Published: December 2023

Pulmonary Aspergillosis is a group of lung disorder occurs due to the infection of Aspergillus species. It has wide range of clinical indications based on the interaction of Aspergillus with the host. The understanding of pathophysiological mechanism of Aspergillus infection is essential in order to minimize the chances of infection as well as to develop treatment strategies. Aspergillosis is found to be associated with various health conditions such as Asthma, Chronic Obstructive Pulmonary Disease (COPD) and Cystic fibrosis. The chances of Aspergillus infection increased in the transplant patient and the patient having immunocompromised state. Diagnosis is mostly done through sputum culture, serological and molecular diagnostic tools. Antifungal therapeutics is considered as treatment strategies along with monoclonal anti Immunoglobulin E (IgE) antibody. In some cases surgery is also preferred.
Isoscalar monopole response in the neutron-rich molybdenum isotopes using self-consistent QRPA
Authors:   Department of Physics, College of Science, Kirkuk University, Kirkuk, Iraq, Taqi A.H. , Mohammed G.A.
Published: December 2023

The isoscalar giant monopole resonance (ISGMR) of even molybdenum isotopes 92,94,96,98,100Mo has been studied within the Skyrme self-consistent Hartree - Fock - Bardeen, Cooper, and Schrieffer and quasi-particle random phase approximation. Ten sets of Skyrme-type interactions of different values of the nuclear matter incompressibility coefficient KNM are used in the calculations. The calculated strength distributions, centroid energies Ecen, scaled energies Es and constrained energies Econ of ISGMR are compared with available experimental data. Due to the appropriate value of the nuclear matter incompressibility KNM, several types of Skyrme interactions were successful in describing the ISGMR strength distribution in the 92,94,96,98,100Mo isotopes. As a result, high correlations between Ecen and KNM were found.
Importation of band head spin for superdeformed bands in mass region A ∼ 60 - 90 using the variable moment of inertia model
Authors:   Department of Physics, Faculty of Science and Arts, Al-Mikhwah, Al-Baha University, Al-Baha, Saudi Arabia, Gado K.A. ,   Basic Sciences Department, Bilbeis Higher Institute for Engineering, Bilbeis, Sharqia, Egypt
Published: December 2023

We are currently applying the variable moment of inertia model to nuclei in mass region A ∼ 60 - 90 in order to improve spectroscopic analysis of its rotational bands in the superdeformed region, which in turn is helpful in the band head spin prediction and other spins for superdeformed bands. The moment of inertia of the ground state, ϑ0 and restoring force constant, C, were calculated by fitting the observed transition energies. The band head spin, I0 was determined in terms of the ratio of transition energies, verified by root mean square deviations. We verified that the observed high spin superdeformed bands display a near-rigid rotor behavior by studying transition energies over twice the angular momentum (RTEOS). The calculated and observed transition energies agree well.
Moving Beyond the Contemporary Approach of Higher Education: From Vivekananda’s Perspective
Authors:   Department of Humanities and Sciences Indian Institute of Technology(ISM), Dhanbad, Mitra Soumita , Prakash Gyan ,   Department of Humanities and Sciences Indian Institute of Technology(ISM), Dhanbad
Published: December 2023

This article seeks to provide a deeper understanding of Swami Vivekananda’s contribution to the field of higher education. Swami Vivekananda, who was an Indian philosopher, propagated the concept of “Man making” by instilling the ideals of “spiritualism” and “natural learning”. Such ideals have gradually developed to be one of the essential prerequisites which the educational system should inculcate. He stressed the importance of a supporting agent in the form of a guide. The latter would direct and further provide a space to allow the natural growth of the child. These two pivotal aspects would contribute to the development of the child. Nonetheless, a balance between the two is also required to trigger a successful learning process. Hence, this work discusses how Vivekananda’s ideals would significantly contribute to solving some of the problems that affect contemporary pedagogies.
Artificial Intelligence: Basic Concepts
Authors: Kozhuharov Mihail
Published: December 2023

This study presents basic concepts embedded in the scientific field of artificial intelligence with an emphasis on key aspects and methods of application. Concepts such as machine learning with its varieties such as supervised, unsupervised machine learning and reinforcement learning are explored, emphasizing the importance of machine learning, which allows systems to adapt and improve without explicit programming. The specifics of deep machine learning are discussed, with an emphasis on their capacity to process complex data and extract patterns. The article also examines some of the areas that make up artificial intelligence, such as natural language processing, large language models, computer vision, generative artificial intelligence, and others. By discussing these key concepts, the article aims to provide a basic understanding of the application and potential of artificial intelligence in various spheres of society.
Artificial Intelligence in Education – Pedagogical Reflections
Authors: Georgieva-Hristozova Violeta
Published: December 2023

This theoretical framework represents an author’s reflective approach, characterized by a predominant focus on descriptive, analytical, and prognostic elements. It aims to introduce artificial intelligence virtual assistants, and explore their potential in the educational context of preschool children, students and university students within the pedagogical scientific community. The paper is a theoretical analysis encompassing the understandings of virtual assistants, their evolution, pedagogical potential and pertinent reservations related to their application in education. Additionally, a concise questionnaire is administered to Bulgarian students and professors, gauging their attitudes towards the use of artificial intelligence in university didactics. Importantly, it is imperative to emphasize that this investigation does not challenge traditional pedagogical approaches; rather, it serves to complement and enrich the existing theoretical and practical knowledge base. Such enrichment becomes essential in response to the shifting dynamics of societies in the post-digital era, alongside the distinctive characteristics of the contemporary learning generations. As society progresses towards an increasingly digital future, the transformation of education into a more digital-oriented landscape becomes an inevitable necessity.
Effect weight training on muscular hypertrophy: a systematic review
Authors: Ihsan Fadli , Nasrulloh Ahmad , Nugroho Sigit , Yuniana Rina
Published: December 2023

Background and Study Aim. In the context of the growing importance of strength training, the analysis of the impact of strength loads on muscle hypertrophy becomes increasingly significant. Therefore, it is critical to comprehend both the effects of strength training on stimulating muscle growth and the potential ramifications. This study aimed to systematically analyze and collate the existing scientific evidence on the effects of weight training on muscle hypertrophy.

Material and Methods. The research method involved the source selection of relevant studies from various databases, with predefined inclusion criteria. A thorough literature search was conducted, followed by data extraction focusing on study design, subject population, type of weight training, duration, and outcome measures of muscle hypertrophy. Databases such as PubMed, Google Scholar and Scopus were the primary sources of literature searches.

Results. The results of this systematic review indicated evidence supporting the positive effect of weight training on muscle hypertrophy in most of the studies included. However, some studies produced controversial findings or even showed no significant impact. Factors such as variations in exercise type, intensity, and frequency also influence the outcome of weight training on muscle growth.

Conclusions. While weight training has the potential to stimulate muscle hypertrophy, its effects may vary based on various factors. Therefore, selecting the correct type of exercise, setting the appropriate intensity, and planning the frequency of activity is essential in achieving optimal results. This study has strong relevance in fostering effective and safe exercise programs.It can also serve as a basis for further research in exploring other factors that may influence weight training-induced muscle hypertrophy outcomes.
A game model in physical education to improve motor skills, cooperation, and discipline of primary school learners
Authors: Fizi Resti Molina , Winarni Sri , Guntur  , Hartanto Amri
Published: December 2023

Background and Study Aim. Motor skills, cooperation, and discipline are important for elementary school children. The purpose of this research is to develop a game-based physical education learning model that is effective in improving motor skills, cooperation, and discipline in elementary school students.
Material and Methods. This type of research is Research and Development with the ADDIE model (Analysis, Design, Development, Implementation, Evaluation). The validation subjects of the game-based learning model are six expert lecturers with professors and doctoral degrees. The effectiveness test subjects were 46 upper grade elementary school students (aged 10-12 years). The statistical analysis used was Aiken validity analysis and Intraclass Correlation Coefficients, and to analyse the effectiveness of the product using paired sample test analysis.
Results. The results show that the game-based learning model is effective for improving motor skills (p-value 0.000 < 0.05), cooperation (p-value 0.000 < 0.05), and discipline (p-value 0.000 < 0.05) in upper grade elementary school students. The developed learning model is valid and reliable, so it is very effective to be used by Physical Education teachers for the learning process.
Conclusions. The learning model through this game is expected to be able to bridge the shift in the character values of students in a good direction, along with the development of games and technology that are very strong magnets. For further researchers, further studies and developments are needed to add to the repertoire of game models to improve motor skills, cooperation, and discipline. This will support the learning process of physical education in elementary schools in accordance with the applicable curriculum.
Use of game tools in martial arts for endurance development
Authors: Marchenko Svitlana , Ivashchenko Olha , Khudolii Oleg , Lubchenkov Renat
Published: December 2023

Background and Study Aim. The purpose of research is to test experimentally the effectiveness of the influence of game means on the dynamics of endurance development in 10-year-old boys who attend the sports section of Kyokushinkai karate.
Material and Methods. Forty 10-year-old boys engaged in Kyokushinkai karate took part in the research. The children and their parents were informed about all peculiarities of the research and agreed to participate in the experiment. The following research methods were used to solve the tasks: analysis of scientific and methodological literature, pedagogical testing, and methods of mathematical statistics for processing research results.
Results. Statistically significant changes in results occurred in the studied groups (p<0,001). The improvement of the level of endurance development in 10-year-old boys’ karate athletes in favor of EG is confirmed. The highest statistically significant changes in EG indicators (р<0.001) occurred in tests "Bent arm hang" (14.6%), "Push-ups" (11.8%), "Burpee" (11.8%). The average performance in 300 m run (8.6%) and in kicks "Mawashi geri chudan" with the right (left) foot slightly increased by 9.8% and 8.1%, respectively. There was no significant difference in the results of the test "Sit-ups in 1 min from the supine position" between EG and CG groups (1.1%, p>0.05). However, both groups showed a sufficiently confident increase in the level of local dynamic power endurance (EG – 11.6%, CG – 10.4% at p<0.001).
Conclusions. The level of boys’ endurance at the initial stage of the pedagogical experiment corresponds to proper age norms. According to most results, 36% of boys are classified as of average level, 16.5% as above average, 17% as high. The rest of the indicators were distributed between below average and low levels, 12% and 18.5%, respectively. A significant lag was found in terms of general endurance (300 m run test). The dynamics of the obtained data testified to the effectiveness of the developed, tested, and implemented physical education methodology of endurance development in 10-year-old boys’ karate athletes with outdoor games. Because of application of game load (5 games, 3 repetitions with rest intervals of 20 s) there was a statistically significant increase in endurance (р<0.001).
Modelling the release of Mo, Tc, Ru and Rh from high burnup spent nuclear fuel at alkaline and hyperalkaline pH
Authors: Giménez Javier , De Pablo Joan , García-Gómez S. , Serrano-Purroy Daniel , Iglesias Luis , Clarens Frederic , Martínez-Torrents Albert
Published: December 2023

The present work shows experimental data on the release of some radionuclides that are forming the so-called ε particles in the spent nuclear fuel (SNF): Mo, Tc, Ru and Rh. The leaching experiments were carried out with a 60 GWd·t−1 burnup SNF at two different pH values, 8.4 and 13.2, and under oxidizing conditions. The modelling of the data showed that the higher release of Mo, Tc, Ru and Rh at pH 13.2 could be due to the higher dissolution rate of the ε-particles.

Graphical abstract
Oxidative stress and antioxidants markers in individuals with thyroid hormones dysfunction
Authors:   Department of Medical Laboratory Science, College of Medicine and Health Sciences, Afe Babalola University Ado-Ekiti, Ekiti State, Nigeria, Omon Emmanuel Akokhamen , Ajayi Olawale David ,   University Health Center, Bamidele Olumilua University of Education, Science and Technology Ikere, Ekiti State, Nigeria
Published: December 2023

Introduction and aim. Thyroid hormone abnormalities have been associated with oxidative changes in human beings. The aim of the study was to evaluate the oxidative stress marker and antioxidants status in individuals with thyroid hormone dysfunction in Ekiti State. Material and methods. A total of eighty samples were recruited in this study comprising forty subjects with thyroid hormones dysfunction and forty apparently healthy controls. Malondialdehyde (MDA), reduced glutathione (GSH) and catalase were determined spectrophotometerically. Results. MDA was non-significantly higher (p>0.05) in subjects (4.33±0.84 nmol/mL) compared with control (4.12±0.63 nmol/mL), catalase was non-significantly higher (p>0.05) in subjects (199.36±20.21 µm/mL) compared with control (181.55±16.61 µm/mL), while GSH was significantly lower (p<0.05) in subjects (79.31±10.12 µmol/mL) compared with control (127.21±7.29 µmol/mL). Conclusion. It can be concluded that the increase in the reactive oxygen species accompanied with impairment of the antioxidant system occurs in patients with thyroid hormone dysfunction. Hypothyroidism and hyperthyroidism induces disequilibrium of the oxidative/anti-oxidative balance that can lead to subsequent development of inflammation and associated diseases.
Exploring the versatility of ciclopirox – from anti-fungal to anticancer agent and beyond
Authors:   Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Vile Parle, Mumbai, India, Singh Dhishank , Kaur Ginpreet ,   Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Vile Parle, Mumbai, India, Chintamaneni Meena ,   Shobhaben Pratapbhai Patel School of Pharmacy and Technology Management, SVKM’s Narsee Monjee Institute of Management Studies, Vile Parle, Mumbai, India, Joshi Hemant ,   School of Biotechnology, Jawaharlal Nehru University, New Delhi, India, Ramniwas Seema ,   University Centre for Research and Development, University Institute of Pharmaceutical Sciences, Chandigarh University, Gharuan, Mohali, India, Tuli Hardeep Singh ,   Department of Bio-Sciences and Technology, Maharishi Markandeshwar Engineering College, Maharishi Markandeshwar (Deemed to be University), Mullana-Ambala, India
Published: December 2023

Introduction and aim. Ciclopirox has been treating fungal infections for decades. Recent studies suggest ciclopirox may be repurposed to treat cancer, viral infections, and neurological disorders. Ciclopirox exerts anticancer by inhibiting multiple pathways of cancer cell growth and survival and anti-viral actions by reducing viral replication and altering the host immunological response to viral infection. Recent research suggests that ciclopirox may protect against neurodegenerative illnesses including Alzheimer’s and Parkinson’s. This narrative review shows ciclopirox’s potential to treat cancer, viral infections, and neurological diseases. Material and methods. Current relevant research publications focused on ciclopirox and its repurposing medicinal potential, therefore a well-designed technique was used to find them. „Ciclopirox”, „Anti-fungal”, „Anti-cancer”, „Repurposing”, and „Therapeutic potential” were used to search PubMed, Web of Science, EMBASE, and Google Scholar. Analysis of literature. Ciclopirox may reduce oxidative stress and inflammation, which may cause several illnesses. Overall, the repurposing of ciclopirox for the treatment of cancer, viral infections, and neurodegenerative disorders represents a promising avenue of research that warrants further investigation. Conclusion. It was concluded that CPX and olamine derivatives as outstanding antifungal medications, as well as provide information on ongoing research to use them for other illnesses.
Characterization of SUS-treated amputees at the Itanhaém Municipal Rehabilitation Center from 2012 to 2020
Authors:   Centro Universitário Lusíada, Santos, Brasil, Artioli Dérrick Patrick , Bertolini Gladson Ricardo Flor ,   Universidade Estadual do Oeste do Paraná, Cascavel, Paraná, Brazil
Published: December 2023

Introduction and aim. Analyzing the factors related to amputations and understanding which factors are changeable can assist in the development of public policies for the prevention and education of the population. Objective: To describe the main etiological characteristics and symptoms after amputation in the Unified Health System (Sistema Único de Saúde – SUS) patients in order to contribute to the information for treatment planning by the multiprofessional team for these patients. Material and methods. Retrospective study from 2012 to 2020, evaluating data from all amputation cases seen at the Itanhaém Municipal Rehabilitation Service, SP. Results. 76 cases were studied, mostly middle-aged men, Caucasian, smokers, hypertensive, type II diabetics, some with dyslipdemia, cardiopathies, and the main cause of amputation was infection after wound. Conclusion. The population needs to be warned about the risk of amputation due to infected wounds in patients with difficulty in controlling their comorbidities. Patients who have undergone amputation, should be oriented towards an early utilization of rehabilitation services, and municipalities should prepare their medical and rehabilitation professionals for the treatment of characteristic symptoms that amputees report and prosthetization.
Predictors of adverse perinatal outcomes in women at 40 weeks or more of pregnancy
Authors:   Department of Gynecology and Obstetrics, Aksaray University Medical School, Aksaray, Turkey, Sert Zekiye Soykan , Dilmaç Ayşegül Evren ,   Department of Gynecology and Obstetrics, Aksaray University Education and Research Hospital, Aksaray, Turkey, Alkan Ender ,   Department of Radiology, Aksaray University Medical School, Aksaray, Turkey, Sert Ekrem Taha ,   Department of Emergency Medicine, Aksaray University Medical School, Aksaray, Turkey
Published: December 2023

Introduction and aim. To evaluate the clinical features of women at ≥40 weeks of pregnancy and the utility of obstetric Doppler indices in predicting adverse perinatal outcomes in these pregnancies. Material and methods. This prospective study was conducted at a single academic medical center between 2020 and 2022. Women aged 18 years and older with no risk factors who were at ≥40 weeks of pregnancy and delivered their babies in our hospital were included in the study. The fetal biometry, placental maturity grading, and doppler velocytometry indices of the pregnant women were evaluated. The cases were divided into two groups according to the development of adverse perinatal outcomes. The relationship between clinical features and adverse perinatal outcomes was evaluated. Results. Adverse perinatal outcomes developed in 19.6% (42) of the 214 cases. The multiple logistic regression analysis was performed to identify factors affecting perinatal outcomes. Accordingly, a maternal age of ≥35 years (odds ratio [OR]: 1.74, 95% confidence interval [CI]: 1.29–3.96, p=0.038), nulliparity (OR: 1.42, 95% CI: 1.13–4.63, p=0.040), and grade 3 placental calcification (OR: 1.98, 95% CI: 1.11–4.53, p=0.029) were independent predictors of adverse perinatal outcomes. Conclusion. Care should be taken in terms of adverse perinatal outcomes in the presence of nulliparity, a maternal age of ≥35 years, and grade 3 placental calcification in ≥40 week pregnancies.
Challenges of the COVID-19 pandemic for children and their families during home quarantine in Turkey
Authors:   Department of Midwifery, Faculty of Health Science, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, Aydın Bahise , Çalbayram Nazan Çakırer ,   Department of Nursing, Faculty of Health Science, Çanakkale Onsekiz Mart University, Çanakkale, Turkey, Altundağ Sebahat ,   Department of Nursing, Denizli, Faculty of Health Science, Pamukkale University, Pamukkale, Turkey
Published: December 2023

Introduction and aim. The COVID-19 pandemic has caused significant changes in human life. As a result of these changes, it is important to determine the effects on the child and family life. This study was conducted to determine the challenges experienced by children and their families while home quarantine in the pandemic. Material and methods. The study was conducted with parents who had children aged 6-18, use social media, and willing to participate in the study. A total of 450 parents participated in the study. Online survey was used. Results. It was determined that some of parental daily activities decreased (doing sports, communicating with friends, engaging in hobbies) and some of them increased (personal hygiene, internet, and playing games with their children). The decreased daily activities of children (doing sports and communicating with friends) and increased activities (eating, personal hygiene, internet, and social media use, playing with toys and technological devices) were detected. There was an increase in some of the family activities (watching movies, playing games, and studying). Conclusion. It was determined that the home quarantine in the pandemic led to some negative changes in the daily living habits, lifestyles, and feelings of the family.
Intraoperative Embolization during Inferior Vena Cava Tumor Thrombectomy for Renal Cell Carcinoma
Authors: A. Roberts Samantha , Satija Divyaam , Gold Henry , S. Makary Mina , G. Wang Jing , A. Singer Eric , Posid Tasha , A. Mokadam Nahush , Dason Shawn
Published: December 2023

Intraoperative tumor thrombus embolization is a potentially lethal complication during inferior vena cava (IVC) thrombectomy for renal cell carcinoma (RCC). Intraoperative embolization is uncommonly encountered because IVC thrombectomy surgical technique is focused on avoiding this complication. Nonetheless, early recognition of embolization is essential so that emergent management can be instituted. When available, cardiopulmonary bypass (CPB) and embolectomy should be considered the gold standard for the management of intraoperative embolization. Several novel endovascular techniques are also available for selective use. We present the case of a 71-year-old female with a right renal mass and level II (retrohepatic) IVC tumor thrombus. During cytoreductive nephrectomy and IVC thrombectomy, tumor embolization was diagnosed during a period of hypotension based on transesophageal echocardiographic finding of new thrombus within the right atrium. This prompted sternotomy, CPB, and pulmonary artery embolectomy. The patient survived this embolization event and has a complete response to systemic therapy 9 months postoperatively. This case serves as the framework for a discussion on management considerations surrounding intraoperative embolization during IVC thrombectomy.