bluuebunny/crossref_metadata_2025 huggingface dataset:
Single-Nephron GFR in Different Glomerular Basement Membrane Stages of Membranous Nephropathy
Authors: Okabayashi Yusuke , Tsuboi Nobuo , Marumoto Hirokazu , Sasaki Takaya , Haruhara Kotaro , Kanzaki Go , Koike Kentaro , Ueda Hiroyuki , Shimizu Akira , Puelles Victor G. , D'Agati Vivette , Yokoo Takashi
Published: May 2023

Key Points

The first study that estimated single-nephron GFR (SNGFR) in patients with membranous nephropathy (MN).

Associations of SNGFR with MN staging by electron microscopy and clinicopathologic findings were cross-sectionally investigated.

This study illustrates a role for disease-specific GBM structural lesions as determinants of SNGFR in patients with MN.

Background

Alterations in single-nephron dynamics have been demonstrated in animal models of membranous nephropathy (MN). This study applied a recently developed technique to estimate single-nephron parameters in human MN.

Methods

Single-nephron GFR (SNGFR) and single-nephron urinary protein excretion (SNUPE) were calculated by dividing total GFR and UPE by the total estimated number of nonglobally sclerotic glomeruli (NSG). The NSG number per kidney was estimated using cortical volume assessment and biopsy-based stereology. MN staging by electron microscopy was performed using Ehrenreich-Churg (EC) criteria. Single-nephron parameters were analyzed in relation to clinicopathological factors known to associate with disease outcomes.

Results

The study included 109 patients with MN (mean age 65 years; 73% male; eGFR 62 ml/min, 36% on renin-angiotensin-aldosterone system inhibitors prebiopsy). EC stages were I, 19%; II, 49%; III, 26%; and IV, 6%. There was no difference in glomerular volume among EC stage groups. With advancing EC stage, SNGFR and SNUPE decreased from mean 56–42 nl/min and 5.1–3.8 µg/d, respectively. In multivariable models, EC stage was associated with SNGFR even after adjustment for key clinicopathological factors, such as reduced GFR, serum albumin, UPE, segmental glomerulosclerosis, chronic tubulointerstitial damage, and prebiopsy use of renin-angiotensin-aldosterone system inhibitors. By contrast, EC stage was not associated with glomerular volume and SNUPE after multivariable adjustment.

Conclusions

These results provide the first clinical evidence of alterations in single-nephron dynamics with advancing EC stage of human MN and support a role for disease-specific glomerular basement membrane structural lesions as determinants of SNGFR.
High Albumin Clearance Predicts the Minimal Change Nephrotic Syndrome Relapse
Authors: Kuno Hideaki , Kanzaki Go , Sasaki Takaya , Haruhara Kotaro , Okabe Masahiro , Yokote Shinya , Koike Kentaro , Tsuboi Nobuo , Yokoo Takashi
Published: May 2023

Key Points

Albumin kinetics not only reflected the pathophysiology of minimal change nephrotic syndrome but was also a predictor of relapse.

The high estimated 24-hour albumin clearance predicts the minimal change nephrotic syndrome relapse.

The 24-hour albumin clearance can easily be calculated from only serum albumin and urinary protein excretion, which are routine laboratory measurements.

Background

Although albuminuria leakage that occurs in minimal change nephrotic syndrome (MCNS) may be related to the disease state, albumin kinetics in MCNS has never been evaluated. In this study, we investigated albumin kinetics in adult Japanese patients with MCNS by the estimated 24-hour albumin clearance (eCALB) and examined the association between eCALB and relapse.

Methods

We retrospectively identified 103 adult patients with a histological diagnosis of MCNS from four hospitals in Japan (2010–2020). The primary outcome is the first relapse in 2 years after complete remission after corticosteroid therapy. The eCALB [µl/min] was defined as (2.71828(0.0445+0.9488×log(urinary protein) [g/24 hours])/(serum albumin [g/dl]×1440 [min/24 hours]) for women and (2.71828(-0.1522+0.9742×log(urinary protein) [g/24 hours])/(serum albumin [g/dl]×1440 [min/24 hours]) for men.

Results

Relapse was observed in 44 patients (103 kidney biopsy samples; 42.7%). The mean patient age was 41.0 years. Patients had an eGFR of 71.0 ml/min per 1.73 m2, urinary protein excretion of 6.8 g/d, serum albumin of 1.4 g/dl, and eCALB of 2.27 μl/min. eCALB was strongly associated with hypoalbuminemia, severe proteinuria, lipid abnormalities, and coagulopathy. In the multivariable analysis, a high eCALB was significantly associated with relapse after adjusting for age, eGFR, time to complete remission, and urinary protein excretion (adjusted hazard ratio, 5.027; 95% confidence interval, 1.88 to 13.47; P = 0.001).

Conclusions

This study revealed that eCALB, which could substitute albumin kinetics, reflected the severity of MCNS, and a high eCALB was associated with recurrence.
Matrimonio igualitario y familia heterosexual: dificultades para avanzar en la interculturalidad familiar
Authors: Rico Luis Alfonso Guadarrama , Vilchis Jannet Valero , Garcìa Sandra Lorena Padilla
Published: May 2023

Una gran parte de la cultura mexicana tiene que ver con lo que representa ideológica, política, civil, religiosa y económicamente la dominante familia heterosexual, constituida por la unión sexual de una mujer y un hombre, con fines reproductivos.  Sin embargo, a partir del año 2009, en México se materializó jurídicamente en la ciudad de México, la vía para que las homoparejas mayores de edad puedan contraer matrimonio por vía civil. A partir de ello, incluso con distintas figuras jurídicas, es posible la celebración de este tipo de matrimonios en las 32 entidades del país[1]. He aquí que estamos frente a un desafío para la interculturalidad con respecto al espectro que actualmente configura la diversidad familiar en el país. En la ponencia analizamos cómo el planteamiento hegemónico de la familia heteronormativa, pese a los recientes avances en materia de derechos humanos, de reconocimiento a la identidad sexo-genérica y a otras prerrogativas estipuladas en la Constitución, no se ha logrado la plena coexistencia entre matrimonios y familias hegemónicas y otras formas de vida conyugal-familiar, especialmente aquellas constituidas por las homoparejas y sus respectivos hijos(as), propios o adoptados.
FINANCIAL ASPECT OF IMPLEMENTING THE CONCEPT OF SUSTAINABLE DEVELOPMENT
Authors:   Surgut State University, Surgut, Russia, Имамвердиева М. И. , Бубнова А. О. ,   The Russian Presidential Academy of National Economy and Public Administration, Moscow, Russia
Published: May 2023

An important element in strategic and operational planning, as well as in determining the positioning of an enterprise in market conditions, is an assessment of the sustainable development of companies. A sufficient level of assessment and forecasting of financial and economic indicators allows enterprises to identify key elements and opportunities for implementing the concept of sustainable development, which nowadays is a necessary and fundamental component and the basis for improving the efficiency of functioning. The article demonstrates an analysis of methods for assessing the financial and economic component of sustainable development. The authors are focused on the financial sector of the Environmental, Social, and Governance approach, as well as on the comparison of the author’s sustainable development methods as the most important component of the functioning of a modern enterprise.
UGRA’S CREATIVE CLUSTER AS A TOOL FOR SOCIAL AND ECONOMIC DEVELOPMENT OF THE REGION
Authors:   Surgut State University, Surgut, Russia, Пучкова Н. В. , Шутро Е. Н. ,   Surgut State University, Surgut, Russia, Михуля Д. Ю. ,   Surgut State University, Surgut, Russia
Published: May 2023

The article deals with the features of the creative economy developing in the Khanty-Mansi Autonomous Okrug ‒ Ugra and the necessity to establish a creative cluster as a tool for social and economic development of the region. The article aims to determine the level of development of the creative industries in the region. According to statistical analysis, the level of development of the region’s creative industries, particularly the tourism industries, is insufficient. The region does not attract investors due to such developmental obstacles as territorial remoteness, seasonal diversity, and a severe climate. The authors proposed to develop a creative cluster in Ugra in order to solve the problems in question and change the approach to the management and implementation of tourism in the region.
THE PLACE AND ROLE OF ADMINISTRATIVE REGULATIONS IN THE ADMINISTRATIVE AND ADMINISTRATIVE PROCEDURAL LEGISLATION DEVELOPMENT IN RUSSIA (ON THE EXAMPLE OF THE KHANTY-MANSI AUTONOMOUS OKRUG ‒ UGRA)
Authors:   Surgut State University, Surgut, Russia, Нехайчик В. К. , Камышанова С. С. ,   Surgut State University, Surgut, Russia
Published: May 2023

The article attempts to show the place and role of administrative regulations in the general system of administrative and administrative procedural legislation of Russia, their legal support in the law enforcement practice of the Russian executive authorities at all levels, as well as the legal consequences of their application. The study focuses on the analysis of administrative regulations of the executive authorities of the Khanty-Mansi Autonomous Okrug ‒ Ugra. According to the study, it is necessary to adopt the law of administrative procedures at the regional level, particularly in Khanty-Mansi Autonomous Okrug ‒ Ugra, as there is no such federal law.
The effect of employee engagement on employee outcomes working from home moderated digital learning orientation
Authors: Setiawan Indra , Heriyanti Sinta Sundari
Published: May 2023

During the Covid-19 pandemic, the government told people to stay away from each other. Because of this, the company has a rule that says you can't work from home. Implementing the work-from-home (WFH) policy significantly affects how employees do their jobs. WFH makes employees less interested in their careers, which is terrible. This could be because employees find it hard to communicate and work with digital devices, so they need to learn how to use them. The goals of this study were to (1) determine how employee engagement affects employee outcomes when they WFH and (2) determine how digital learning orientation affects employee engagement and employee outcomes when they WFH. All of the people in this study are employees who work in the Greater Jakarta area of Indonesia and have a WFH policy or are in the process of making one. Samples were taken using a " convenience sampling method," which is not based on chance. The PLS approach SEM method was used to look at the data. The study results show that digital learning orientation does not moderate the effect of employee engagement on employee outcomes WFH.
The effect of ease of use of M-Pajak and ease of use of e-form on MSMEs taxpayer compliance
Authors: Susilawaty Tengku Eka , Azzahra An Suci
Published: May 2023

When a taxpayer complies with all of his or her tax obligations and uses all of their tax privileges, this is known as taxpayer compliance. Tax revenue increases with better taxpayer compliance; conversely, when taxpayer compliance is low, tax revenue and state treasury both decline. As a result, DJP introduced the M-Pajak application and E-Form system, one of the tax administration reforms, with the goal of facilitating taxpayer access to more individualized, quicker, and MSMEs-friendly income tax reporting. The purpose of this study is to determine whether MSMEs taxpayer compliance in Pematang Serai Village, Langkat Regency, North Sumatra, is influenced by how simple M-Pajak and E-Form are to use. 35 MSME taxpayers made up the sample. The research methodology is quantitative, and descriptive statistics with multiple linear regression techniques are used for data analysis. According to the study's findings, M-Pajak and E-Form accessibility both partially and concurrently influence taxpayer compliance.This demonstrates that the simpler a DJP application or system is to use, the higher the rate of taxpayer compliance will be because it's simpler for taxpayers to comply with their tax responsibilities.
Community-Based Ecotourism in Sawarna Tourism Village
Authors: Juliana  , Sihombing Sabrina Oktaria , Suwu Selvi Esther
Published: May 2023

This research is motivated by the importance of developing ecotourism in Sawarna tourism village based on community empowerment to improve the community's economy. The research objective is to determine the development of ecotourism in Sawarna tourism village based on community empowerment. The research approach uses a qualitative approach. There were two participants whose information was investigated by researchers, namely the Chairperson of the Nusantara Tourism Village, Banten Province as Secretary of the Sawarna Tourism Village and the head of the Pokdarwis of the Sawarna Tourism Village. The MOA model is based on theoretical perspectives from a variety of fields, including advertising, consumer behavior, tourism, public participation, and, most recently, event studies. The MOA model's key strength is that it can be applied to destinations with the goal of enabling or facilitating community participation.  The MOA model, an already established theoretical framework in the field of tourism, and a desire to understand and document the factors that influence inclusive engagement within local communities inspired this paper. A tourism village built with the concept of community-based tourism is a step for the community to develop their potential to be able to manage their own tourism and make their village an independent village.
Effect of price fairness, service quality, brand imagedand product quality on consumer satisfaction Electric Cars (Ev) in Indonesia
Authors: Serrano Levi Jose Antonio Horacio Da Costa , Innocentius Bernarto
Published: May 2023

This study aims to analyze the effect of price fairness, service quality, brand image and product quality on consumer satisfaction of electric cars (EV) in Indonesia. This research was conducted on 200 electric car (EV) consumers in Indonesia. The sample of respondents was selected according to the criteria and data collection questionnaire with a Likert Scale distributed online. In this study, the PLSSEM method was used to analyze the data. The results of the study are that service quality and product quality affect consumer satisfaction of electric car (EV) consumers in Indonesia positively and significantly, while the variables that have no effect are price fairness and brand image.
The impact of anthropomorphism, consumer trust, and consumer attitude on purchase decisions of environmentally friendly products
Authors: Munawar Fansuri , Handayani Rini , Nilasari Irma , Yudanegara Aditya , Oktaviani Desy
Published: May 2023

Environmentally friendly product purchase behavior is receiving increasing attention in the current marketing literature because understanding it is critical to the growing number of companies developing and marketing green products. However, only some know the importance of environmentally friendly products that can reduce adverse environmental effects. This study aims to analyze the factors that can increase consumer purchasing decisions for this environmentally friendly product. This study examines anthropomorphism, consumer trust, and attitudes toward purchasing decisions for environmentally friendly products. Sampling was conducted on 200 respondents who use environmentally friendly products in Bandung. The data analysis used is a structural equation model based on partial least squares (SEM-PLS) with the help of SmartPLS 3.0. All hypotheses in this study were accepted based on the data processing results. It means that anthropomorphism can have a positive effect on consumer trust and consumer attitudes. In addition, anthropomorphism, consumer trusts, and consumer attitudes can also directly influence the purchasing decisions of environmentally friendly products.
The effect of strategic good corporate governance and human resources management on organizational performance of the Indonesian Navy Aviation Center Mediated by Organizational Culture
Authors: Musani Imam , Arafah Willy , Djati S.Pantja
Published: May 2023

The purpose of this study was to examine the effect of strategic Good Corporate Governance and human resources on organizational performance of the Indonesian Navy Aviation Center mediated by organizational culture. The population in this study were Puspenerbal soldiers and Puspenerbal Surabaya ranks with a total sample of 314 respondents. This study uses path modeling analysis techniques with AMOS tools. From the tests conducted, it was found that Strategic Good Corporate Governance has a positive effect on organizational performance, Human resource management has a positive effect on organizational performance, Strategic Good Corporate Governance has a positive effect on organizational culture, Human resource management has a positive effect on organizational culture, Organizational Culture has a positive effect on Organizational Performance, Organizational Culture mediates the effect of Strategic Good Corporate Governance on organizational performance and Organizational Culture mediates the effect of Human Resource Management on Organizational Performance
Price and taste analysis of coffee consumer satisfaction Janji Jiwa Batam City
Authors: Herman Hendri , Sitanggang Christoper HP , Sufiyandi  , Lova Aldino Masni
Published: May 2023

The purpose of this study is to determine the effect of price and taste on consumer satisfaction of Kopi Janji Jiwa. The population in this study is consumers of Kopi Janji Jiwa. The sample in this study was 100 consumers. Data was obtained by distributing questionnaires to respondents. The data that has been collected will be processed using the SPSS application. Sampling method using simple random sampling. From the results of the study, it is known that price has a significant effect on consumer satisfaction. Taste has a significant effect on consumer satisfaction. And simultaneously price and taste have a significant effect on consumer satisfaction. The r square value in this study was 0.325 or 32.5%. This means that price and taste are able to explain consumer satisfaction by 32.5%. While the remaining 67.5% was influenced by other variables that were not included in this research model
Influence of factor application between utilizing modified united theory of acceptance and use of the technology 2 model (a study on Shopee users in Indonesia)
Authors: Syanita Rissella Jihan , Indrawati Indrawati , Ghina Astri
Published: May 2023

The internet has become a part of people's daily lives to help them fulfil their needs, such as enabling them to trade or do business utilizing e-commerce applications. Shopee is one of the most well-liked e-commerce platforms in Indonesia, boasting 93 million active users. This study used the modified UTAUT 2 model to conduct a descriptive analysis to identify the application user assessment. Subsequently, the SEM PLS analysis was conducted to identify variables influencing the continuation intention of application usage and the impact of the continuation intention on the user behavior of Shopee application users. The study also sought to ascertain the impact of age and gender on the other variables in the study model. As a result, the business can identify user preferences and factors that affect how often users use the Shopee program, enabling it to maintain its appeal in the face of strong competition. The study findings revealed that social influence, perceived security, and risk received lower ratings than other categories. In conclusion, the intention of application users to continue using it was highly influenced by performance expectations, effort expectations, social influence, enabling conditions, headache incentives, habit, and perceived security and risk.
Village-owned enterprises: analysis and modeling (Study on 69 Villages-Owned Enterprises in Belu District - NTT Province)
Authors: P Mumu Noldy D. , Seran Patrisius
Published: May 2023

The purpose of this study is to explore and map in depth about BUM Desa starting from the institutional, organ and governance system, stakeholders to various problems faced, then analyze it for further designing and recommending a comprehensive and comprehensive Re-Modeling. strategic as a solution for the management of BUM Desa in Belu Regency in particular and in East Nusa Tenggara Province in general. The method used in this study is descriptive qualitative because this method is considered to be able to provide a broader, in-depth and detailed description of the phenomena in the field, in this case the reality conditions of BUM Desa in Belu district. The results of the study show that the problems that have hindered all BUM Desa in Belu district have so far stemmed from the absence of a standardized formal model starting from pre-operational; operational implementation; post operational.
The effect of marketing orientation on marketing competence and it’s implications on sales performance
Authors: Hendiarto R Susanto , Musthafa Zaenal
Published: May 2023

The current problem is that sales are still far from expectations, while the competencies that must be possessed are also still of concern. This is allegedly because the marketing orientation has not been built according to the business platform, so that many business targets are not achieved. This study aims to determine the effect of marketing orientation on marketing competence and its implications for sales performance, examining case studies on businesses assisted by Kadin Jabar in Bandung. The research method applied was in the form of an analytical descriptive survey method, while the sample used was 39 respondents. The variables studied from each respondent are marketing orientation, marketing competence, and sales performance. The type of data collected is primary data. The results of the study show that marketing orientation has a significant effect on marketing competence. Marketing competence has a significant effect on sales performance. The implication is that the marketing orientation of MSMEs as a stimulus must be immediately decided by management to create competent human resources, especially in the field of marketing, in order to produce performance in the field of sales according to target achievements. The object of this research is that the responden sample used is still limited to the West Java Kadin assisted businesses in Bandung, therefore it is necessary to carry out further research based on a more varied sampling with a longer duration, so that results can be generalized.
Literature study: measuring banking performance in Indonesia due to policies for handling the covid-19 pandemic
Authors: Simanjuntak Dahnil Anzar , Hartawan Andre Mirza , Aditya Mochammad Yana
Published: May 2023

The Covid-19 pandemic, with its peak period in 2019-2021, has, directly and indirectly, affected banking performance in Indonesia. Many studies have been conducted with mixed results. Based on the results of previously published studies, this study seeks to see banking performance due to the Covid-19 pandemic. Using the literature review approach, the study gets 100 scientific articles from the database of international and national journal providers Google Scholar with the Publish or Perish 8 tool. Based on the selection of 100 research data obtained, as many as 55 selected articles. Selected articles are based on the relevance or suitability of the material. A total of 45 articles were not selected for several reasons, such as inappropriate material, no publisher/source found, and irrelevant research results. Findings of this study, the impact of the Covid-19 pandemic in Indonesia was classified into three: reducing performance, enhancing performance, and neutral or diverse.
The impact of green investment, media coverage, and international sales on carbon emission disclosure with audit committee as the moderating variable
Authors: Mulyati Rina , Darmawati Deni
Published: May 2023

This study aims to examine the effect of green investment, media exposure and international sales on disclosure of carbon emissions with the audit committee as a moderating variable. Researchers took data on companies from 2018 to 2021 and used energy company analysis units, basic materials and non-cyclical consumers listed on the Indonesia Stock Exchange. The method of determining the sample in this study is using purposive sampling. The results of this study indicate that green investment has a positive and significant effect on disclosure of carbon emissions, while media exposure and international sales have no significant effect on disclosure of carbon emissions, while the audit committee moderates the effect of green investment and international sales on disclosure of carbon emissions, and the audit committee does not moderate the influence of media exposure on disclosure of carbon emissions.
Utilization mother and child health book on knowledge pregnant women
Authors: Yonni Siwi Retno Palupi , Retnaningtyas Erma , Wulandari Anggrawati , Astikasari Nita Dwi
Published: May 2023

The low knowledge of pregnancy care is influenced by the lack of information so that it has an impact on the utilization of MCH book. The purpose of this study was to analyze the effectiveness of the use of the MCH book on knowledge about pregnancy care for pregnant women. This study used a correlational analytic  with a  cross sectional. The population in this study were 40 respondents with a total sample of 36 respondents using the simple random sampling technique. Data collection by using a questionnaire, statistical test Spearman Rank. The results showed that 36 respondents, almost half of the respondents used MCH book in the high category, namely 15 respondents (41.7%), most of the respondents had knowledge of good pregnancy care, as many as 26 respondents (81.2%) . The results of data analysis using the Spearman Rank obtained a P value of < 0.05 (0.000 < 0.05), which means that the use of MCH book is effective on knowledge about pregnancy care in pregnant women. The utilization of the MCH book as a source of information and medical records as well as an important communication tool and information medium for health workers, pregnant women and families.
Anemia in pregnant mothers and the apgar score of newborn babies at secondary refferal hospital, Bali
Authors: Dwipayana Cokorda Agung Prasetya , Bayuningrat I Gusti Ngurah Made , Permatananda Pande Ayu Naya Kasih , Lestarini Asri
Published: May 2023

Low hemoglobin levels due to anemia in pregnancy can affect the baby's APGAR score. The purpose of this study was to determine the relationship between anemia in pregnant women and the APGAR score of newborns at the Sanjiwani Hospital, Gianyar. This research is an analytic observational study with a cross sectional research design. This study used medical records data of patients who gave birth vaginally and had normal births, did not have low birth weight, had normal first and second stages of labor, and had complete laboratory data on hemoglobin levels and APGAR scores. Data on mothers experiencing obstetric complications other than anemia were excluded from this study. Data were analyzed by univariate and bivariate using Chi-square hypothesis test. From 140 samples of pregnant women, there were 78 (55,7%) samples of pregnant women who had anemia and 62 (44,3%) samples of pregnant women was not had anemia. Bivariate analysis showed that there was a significant relationship between anemia in pregnant women and the APGAR score of newborns with p value = 0.001 (p <0.05). We concluded that there was a relationship between anemia in pregnant women and the APGAR score of newborns at the Sanjiwani Hospital, Gianyar.
Herpes zoster in a 4-year-old child with pulmonary tuberculosis: a case report
Authors: Nainggolan Nadya , Eric  , Anditha Putri Natasya , Dorthy Santoso Irene
Published: May 2023

Herpes zoster (HZ) is a dermatomal virus infection caused by the reactivation of latent varicella zoster virus (VZV) in sensory ganglia neurons that is previously exposed to primary varicella infection. Herpes zoster is a rare disease experienced in children and is often associated with an immunocompromised condition. A case of a girl four years old with a vesicle on the right chest which spread to the upper armpit and right inguinal was reported. The lessions were obtained on Thoracoaxilla as high as T4 and Inguinal as high as L1 dextra. The patient was treated with acyclovir doses of 30 mg/Kg/day for seven days and showed significant improvements.
Intervention for Pressure Injuries Prevention in Bed Rest Patients
Authors: Chayati Nur , Nurachman Sinta Yudistia
Published: May 2023

Pressure injuries, also known as pressure injuries or hospital-acquired pressure injuries, was damage to the integrity of the skin or soft tissue in a local area that tends to compress the bony prominences with the surface area due to a combination of prolonged pressure such as friction, shear and moisture. The main groups at risk for pressure injuries were patients with spinal cord injuries, hospitalized patients, especially those undergoing orthopedic surgery and patients admitted to the intensive care unit (ICU). The purpose was to determine the types of tools, materials, techniques and nursing interventions for the prevention of pressure injuries in bed rest patients. The research used a literature review using 3 databases, namely Science direct, Pudmed, Google Scholer with studies design included Quasi Experimental and Romdomized Controlled Trials. The study obtained 7 articles describing pressure ulcer prevention interventions such as providing bed rest, giving oral supplements, providing massage therapy and lubricating agents, providing moisturizers in the wound area and providing appropriate mattresses for bed rest patients.
Ulcerative colitis and its correlation with the incidence of colorectal cancer
Authors: Ongko Felix , Kurniawan Santosa Erwin , Then Edward , Anthonny Setiawan Lucky , Ongriana Vivian
Published: May 2023

The purpose of this research to further reviewed the pathogenesis, risk factors, screening, and preventive interventions for colorectal cancer associated with ulcerative colitis.  The research method used descriptive qualitative through the Literature Review (LR) approach. The data source used a secondary source. Data analysis technique selects literature based on title, year, and indexed articles, then reviews articles that match the subject matter. A literature search was performed using databases, such as PubMed, Cochrane Library, and Science Direct. Colitis-associated neoplasia is thought to result from chronic inflammation, which induces changes in epithelial proliferation, survival, and migration through the effects of various chemokines and cytokines. The risk factors are in three main categories: disease-related, patient-related, and pathology-related. The most reliable screening test is colonoscopy, parallel with a structured endoscopic surveillance program that includes ongoing medical management for disease control. There are several chemopreventive options for the early prevention of colorectal cancer in cases of ulcerative colitis.   In general, long-standing chronic inflammation in the intestinal mucosa increases the risk of colorectal cancer due to genetic and molecular alterations. Identifying high-risk groups and colonoscopic surveillance programs have been considered useful early detection measures.
Analysis of factors associated with early menarche in adolescents
Authors: Yustanta Brivian Florentis
Published: May 2023

The incidence of menarche praecox is 5.2% of adolescents in Indonesia. Indonesia ranks 15th out of 67 countries with a decline in menarche age of up to 0.145 years per decade. The study aimed to analyze factors associated with early menarche (praecox menarche) in adolescents. This type of analytic research with quantitative methods and crosssectional research design. This used primary data, the instruments used microtoise, weight scales, and checklists. The population was 145 adolescents. The sample size was 124 respondents using simple random sampling. The research was tested using the Chi Square test. It was conducted in Kediri on October to December 2022. The research results were found that adolescents who experienced praecox menarche were 41.9%, nutritional status was not obese by 75.2%, exposed to pornography by 65.6%, genetics (early menarche age of mother) by 51.2%, not active in sports by 69.6%. From the results of data analyze it can be concluded that there was no correlation between nutritional status and praecox menarche (P-value 0.100), there was correlation between exposure to pornography and praecox menarche (P-value 0.000), there was correlation between genetics and praecox menarche (P-value 0.002), there was correlation between physical activity (exercise) and praecox menarche (P-value 0.001).
Effectiveness of Cognitive Ayurveda Therapy (CAT) against improving quality of life in patients with type 2 diabetes mellitus at RSU Royal Prima Medan
Authors: Manao Ervin Rudianto , Sihombing Elia Br , Gulo Firdayanti , Tarihoran Marina Stevi , Pardede Puspita Veronica
Published: May 2023

Maintaining normal blood sugar levels is not enough to treat diabetes mellitus. According to Yudianto, Hana, and Ida (2018), people with diabetes mellitus will carry the disease with them throughout their lives, affecting their health issues related to physical, mental, social, and environmental forms of quality of life. This research is compares persons including type 2 diabetes mellitus’ quality of life before and after CAT, in addition to calculate the effectiveness of cognitive Ayurvedic therapy in enhancing this quality of life. As reported by Lapau in Airlangga (2018), this research consists of a number of components that are combined to obtain information or facts to address research issues or questions. A significant diversity among the pre- and post-test values was found by the Paired Sample T-Test, with a significance level of p 0.000, 0.05 (2-tailed). There was a striking difference among the two tests, so the study’s null hypothesis (Ho) was denied and the alternative hypothesis (Ha) was acquired. Ayurveda therapy (CAT) has the highest level of effectiveness for improving respondents' quality of life, with very good results in health issues related to physical, mental, social, and environmental aspects. The Chi-Square pre- and post-test, with a p- value of 0.000, produced the following outcomes at RSU Royal Prima Medan, the persons including type 2 diabetes mellitus’ quality of life is significantly different previously and after treatments.
Suitability of biochar as supplementary cementitious material (SCM) or filler: waste revalorization, a critical review
Authors: Nahuat-Sansores Javier Rodrigo , Cruz-Argüello Julio César , Gurrola Mayra Polett , Trejo-Arroyo Danna Lizeth
Published: May 2023

For decades, researchers on materials science have highlighted the potential of biochar as a CO2 adsorption medium and the possibility of its incorporation into other materials to reduce the overall carbon footprint. This present study is a critical review of a selection of articles about biochar potential as a material on the construction industry. Biochar is a promising material in order to mitigate GHG emissions when added to cementitious materials, reducing its carbon footprint through a dual effect: CO2 sorption and replacement of cement or aggregates. Literature evidenced that replacement ratios of around 2-8 of cement wt% improved or leveled with conventional cementitious composites. However, some recent studies have shown that the incorporation of biochar up to >10% replacement ratios have the potential to improve the composites. Based on this premise, the present review emphasizes on the durability and long-term properties of biochar cementitious composites by providing up-to-date discussions of the studies on the matter and the future perspectives of the research in order to develop more eco-efficient concretes or mortars.
Sorghum halepense (Zacate Johnson) as a potential natural corrosion inhibitor
Authors: Maldonado-Rivas Pablo Javier , García-Ochoa Esteban Miguel , Corvo-Pérez Francisco Eduardo , Chan-Bacab Manuel Jesús
Published: May 2023

Corrosion inhibitors can trigger health and/or environmental problems due to their toxicity. For this reason, it has been suggested to use plant extracts as natural corrosion inhibitors, because they represent a rich source of chemical compounds, they are non-toxic, biodegradable and abundant in nature. Sorghum halepense is a herbaceous weed, commonly known as johnson grass, belongs to the family gramíneae or poaceae, the choice of this plant is due to its zero cost and easy availability.
In this systematic review, were used keywords such as Sorghum halepense johnson grass, phytochemistry, phytotherapy, phytoremediation, antidiabetic, antioxidant, cytotoxicity, antifungal, antimicrobial, anticancer, biological activity, medical activity, allelochemicals, among others. To do this, were used databases such as Scielo, Dialnet, Redalyc, Google Scholar, DOAJ, Wiley online library, BioOne, EBSCOHost, Knovel, ScienceDirect, SpringerLink y VirtualPro. Previous studies on this weed have reported its therapeutic potential against cancer, diabetes, prostatitis, hepatoprotective activity, antioxidant, antimicrobial, antifungal, as well as abortifacient and placental delivery in veterinary medicine. In view of the numerous organic molecules present in this plant, this study proposes Sorghum halepense as a potential natural corrosion inhibitor.
A didactic tool for updating the teaching-learning process of English as a foreign language
Authors: Flores-González Norma , Flores-González Efigenia , Castelán-Flores Vianey , Zamora-Hernández Mónica
Published: May 2023

The teaching-learning process is a binomial in constant change due to its actors and contexts. Therefore, this process requires an update to respond to students’ needs according to their learning styles. Given this situation, the objective of this study is to know if TikTok, as a didactic tool, can contribute to said educational update and develop oral skills since it centers on communicative competence. Regarding the methodology, the descriptive quantitative approach took place on a 50-student sample enrolled in an extracurricular course. The findings provide contributions of a theoretical nature since they characterize TikTok as a didactic tool to update the English teaching-learning process with an innovative, participatory, and collaborative methodology with motivational features and ubiquitous learning. Besides, it contributes to oral skills development through the construction of knowledge, interpersonal relationships, discursive and sociocultural skills development, and the promotion of positive attitudes towards work (commitment).
Process of staff activities National Electoral Institute in electoral jorganda
Authors: Cortés-Alvarez Yolanda , Estrella-Velázquez Rafael , Gonzalez-Neri Aarón Iván , Quezada-Moreno Maribel
Published: May 2023

With this project, the objective was to know the process of activities carried out by the staff on the National Electoral Institute on an electoral day so that Mexicans at the national level know what and how these activities are carried out on an electoral day that could even work at a national and international.
Comprobación experimental del ciclo biológico de Dioctophyma renale, en un área ribereña al río de la Plata
Authors:   , Burgos Lola
Published: May 2023

La dioctofimosis es una enfermedad parasitaria zoonótica, de distribución mundial, ciclo heteroxeno, producida por Dioctophyma renale; los adultos de estos nematodos se encuentran en tejidos, órganos y cavidades de una amplia variedad de mamíferos, los cánidos, con mayor prevalencia. Argentina presenta zonas endémicas, con alto potencial hídrico. La experiencia se realizó con los anélidos Aeolosoma hemprichi y Enchytraeidae, quienes cumplieron con criterios de inclusión prefijados para esta experiencia. Prueba Piloto. Se realizó en Mesocricetus auratus, inoculado con oligoqueto infectados in vitro, de familia Enchitraeidae, en su orina se hallaron huevos de D. renale infértiles en ecografías se observó, ausencia parcial de médula en riñón derecho, imagen vermiforme en cavidad abdominal y riñón. El riñón izquierdo mantuvo su forma y tamaño inalterado. Durante los controles se observó lesión cutánea neoformada, se supone que el verme abandono su ubicación por allí. Murió espontáneamente, en los preparados histopatológicos se observaron huevos y restos de nematodos mineralizados”, así como diversas lesiones coincidentes con las observadas en estudios histopatológicos de casos de dioctofimosis canina. Modelo experimental. Se utilizaron Rattus norvegicus Wistar fue n=10 para cada IME (Enchytraeidae y Aeolosoma hemprichi) y se mantuvo un animal como control. Se realizaron controles al igual que los del M. auratus, una rata (90 días IME, óbito, post anestesia - intra ecografía) en la cual se observó imágenes en hígado, compatible con D. renale. Se realizó necropsia, se enviaron: riñón derecho, riñón izquierdo e hígado y muestras granulomatosas, al servicio de patología, para cortes y coloración histopatológica: las lesiones glomerulares recuerdan aquellas observadas en casos de nefritis inmunomediadas. Se considera este comentario en el contexto de la reproducción experimental. Hígado: marcada congestión y ocasional presencia de amplia cavidad llena de sangre sin ningún tipo de respuesta tisular periférica. Riñón: ambos riñones presentan lesiones similares, observadas en casos de nefritis inmunomediadas. La presencia del hospedador intermediario, la alta prevalencia en caninos, los hábitos alimenticios y recreativos acuáticos de los pobladores, serían suficientes bases para plantear esta hipótesis. Hay que seguir estudiando la zona por posible transmisión a los humanos.
RESEARCH ON APPLE LEAF DISEASE SEGMENTATION AND CLASSIFICATION BASED ON SEMANTIC SEGMENTATION NETWORK
Authors: WANG Bin , LI Lili , LI Shilin , YANG Hua
Published: May 2023

The key to diagnosing the types and degree of apple leaf diseases is to correctly segment apple leaf disease spots. Therefore, in order to effectively solve the problem of poor segmentation of leaves and diseased areas, the U2Net semantic segmentation network model was used in the research of apple leaf disease identification and disease diagnosis, and compared with the classic semantic segmentation network model DeepLabV3+ and UNet. In addition, the effects of different learning rates (0.01, 0.001, 0.0001) and optimizers (Adam, SGD) on the performance of U2Net network model were compared and analyzed. The experimental results showed that the learning rate is 0.001 and the optimizer is Adam, the average pixel accuracy (MPA) and mean intersection over union (MIoU) of the research model for lesion segmentation reach 98.87% and 84.43%, respectively. The results of this study were expected to provide the theoretical basis for the precise control of apple leaf disease.
RESEARCH OF THE AIR FLOW FORM IN THE INTAKE DEVICE FOR SAPROPEL EXTRACTION
Authors: TSIZ Igor , KHOMYCH Serhi , SATSIUK Vasyl , TARASIUK Victor
Published: May 2023

For many years, global researches that focus on improving soil fertility have been conducted. Nowadays, innovative inculcations of environmentally (ecologically) friendly organic agriculture are becoming quite popular. One of the most effective indicators is the use of alternative types of fertilizers. As part of large-scale experiments, researchers propose to use fertilizers made from organic sapropel concentrated in freshwater lakes. Analysis of such studies shows that the impact of sapropel on soil fertility is significant and complex. The main problem they faced is the extraction of these deposits from underwater deposits (fields). Ukrainian scientists have proven the effectiveness of sapropel extraction by means of a pneumatic intake device. To substantiate the rational parameters of this device and visualize the processes, experimental studies of the work of the pneumatic working body were carried out. Namely, experimental studies of the determination of the trajectories of air bubbles in liquids of different viscosity were carried out. According to received trajectories, the boundaries of airflow and its shape are determined. Limpid liquids of different viscosities were used specially in order to see and fix the flow parameters, because it is impossible to observe such a phenomenon in sapropels placed in underwater deposits, due to their opacity and change of viscosity with depth of the bedding. Therefore, the experiment was considered as close as possible to the real one, and the environment of realization of the experiment was simulated. Water, industrial oil and concentrated detergent were selected as investigated liquids. Research data indicate that one can use a whirling airflow for better loosening of deposits of reduced humidity. Whirling occurs when there is a horizontal position of the outlet axis with a diameter in the range of 1-1.5 mm and air pressure of 300-400 kPa.
RICE MECHANIZATION IN ETHIOPIA: TRENDS, AND PROSPECTS
Authors: DESSYE Tikuneh , LAIKE Woldesenbet
Published: May 2023

The domestic rice industry of Ethiopia is constrained by low productivity, poor quality, and old processing machines. The rice production system is done by hand or with rudimentary tools, and only 2% of households have access to tractors. It takes 175 labor days to weed and 66% of the total farm operations. Rice harvesting and threshing are done manually using a serrated sickle and animal trembling respectively. Farmers are responsible for most of the pre-milling operations and store paddy for household consumption in local stores. Challenges include fragmented farm holdings, poor marketing channels, and a lack of awareness of post-harvest utilization. The prospects for rice mechanization development include improving the rice mechanization research system, training local entrepreneurs, providing repair and maintenance services, promoting custom hiring centers, local manufacturing of farm implements, organizing agricultural cooperatives, landholding, and land ownership structures, assessing foreign experience, linking importers and service providers, and encouraging investments in the rural infrastructure.
EFFECT OF AGING TIME AND VACUUM DRYING ON PROXIMATE ANALYSIS AND AMINO ACID LEVELS OF GOAT MILK KEFIR
Authors: SANTOSO Aman , RADIATI Lilik Eka , DAMAYANTI Evi , ARMAINI Armaini , NABILAH-MUJAHIDAH Amiroh , SANJAYA Eli Hendrik , MUNTHOLIB Muntholib , ASRORI Muhammad Roy
Published: May 2023

Goat milk kefir has high nutritional value, especially in protein and calcium content and has a low lactose content. Vacuum drying is an alternative to remove the water content in kefir so that it can extend the shelf life because it inhibits bacterial growth. This study determines the effect of aging time and drying time using vacuum drying method on the characteristics and amino acid composition of goat milk kefir (kefir and powder kefir). Fermented goat milk (24 hours) use kefir grains without aging and with aging times of 1, 2, 3, 4 (week). The total titrated acid and fat content were significantly different in kefir, but it is not significantly different in powder kefir. The yield, moisture, ash, protein, fiber, and fat in both kefir and powder kefir did not show significant differences. The best treatment based on the exponential comparison method for both powder kefir and kefir was 3 weeks of aging time. Therefore, the amino acid components in powder kefir and kefir underwent changes. The highest total amino acids in kefir was kefir without aging. The highest amino acid of powder kefir was obtained after 2 weeks of aging time.