bluuebunny/crossref_metadata_2025 huggingface dataset:
The effect of red algae extract (Euchema spinosum) on dexamethasone induced MDA levels of wistar male white rats (Rattus norvegicus)
Authors: Kumala Asami Rietta , Indri Ngesti Rahayu  , Anang Mufti  , Eric Mayo Dagradi  , Stefanus Djoni Husodo  , I Putu Bagus Dirgantara Dusak  , Larasati Kirana Damayanti  , Lestari Dewi
Published: January 2025

Introduction: Diabetes in liver disease is caused by several factors, including insulin resistance in muscle and adipose tissue, hyperinsulinemia, pancreatic islet cell impairment, and hepatic insulin resistance. Insulin resistance leads to an increase in free fatty acids absorbed by the liver, which leads to steatosis. This condition can result in various complex interactions that can trigger inflammation or progress to cirrhosis. To detect non-alcoholic fatty liver disease (NAFLD), elevated levels of malondialdehyde (MDA) can be used as a benchmark for suspicion. The study aimed to analyze the differences in the administration of Eucheuma spinosum extract on serum MDA and levels of white rats (Rattus norvegicus) Wistar strain induced by dexamethasone.
Methods: A pure experimental study uses a post-test-only control group design, with three groups of 9 white male rats (Rattus norvegicus) plus one spare male rat. K1 is the negative control group (a group of white male rats of the Wistar rat who did not receive the treatment). K2 is the positive control group (a group of white male rats with a diabetes model induced by dexamethasone sodium phosphate at a dose of 8 mg/kg BW). K3 is the treatment group (a group with diabetes model rats with Eucheuma spinosum extract treatment at a dose of 200 mg/kg BW). The three groups measured serum MDA levels at the end of the study.
Results: The highest mean serum MDA levels in white rats were K3 (872.17 + 103.33 nmol/g), and the lowest was K1 (672.50 + 286.49 nmol/g). The statistical test was carried out using the Kruskal Wallis non-parametric test because the mean results do not meet the ANOVA test requirements. The result of the Kruskal Wallis non-parametric test showed no significant differences between groups with p > 0.05.
Conclusion: Giving red algae extract (Eucheuma spinosum) 200 mg/kg BW to white rats has not reduced serum MDA levels of white rats induced by dexamethasone 8 mg/kg BW.
Univentricular repair: a literature review
Authors: Jufri Agil Al , Soebroto Heroe , Hakim Arief Rakhman
Published: January 2025

Link of Video Abstract: https://youtu.be/_dex85zVVSc
 
Univentricular repair is a surgical procedure in patients with congenital heart defects in one of the two ventricles/single ventricles (hypoplasia) or not formed (absent). The univentricular repair procedure is often called the Fontan procedure in that most of these procedures are performed in stages. There are 3 stages of this procedure which in the first stage includes a systemic-to-pulmonary shunt, pulmonary artery (PA) banding, atrial septectomy, and reconstructive procedures such as the Damus-Kaye-Stansel (DKS) and Norwood procedure; the second stage includes classic Glenn shunt, bidirectional cavopulmonary shunt (BCPS), and Hemi-Fontan surgery; and stage three includes atriopulmonary connection Fontan, extracardiac Fontan, and lateral tunnel Fontan operation. Most patients require some form of palliative therapy to regulate systemic and pulmonary arterial blood flow, such as establishing a systemic-to-pulmonary shunt (Blalock-Taussig shunt) or performing a PA bandage. Pulmonary artery reconstruction, DKS, and the Norwood procedure may be required. After 3 months, patients with a single ventricle can undergo the Bidirectional Glenn Shunt procedure, and after 18 months, these patients can undergo the Fontan procedure. Strategies for managing congenital heart disease have increased, so mortality and quality of life have also increased.
Administration of Recombinant Human Bone Morphogenetic Protein-2 (rhBMP-2) and Chitosan Scaffold in calvarial bone defects in Wistar rats
Authors: Sanjaya I Gusti Putu Hendra , Maliawan Sri , Sudarsa I Wayan , Mahadewa Tjokorda Gde Bagus
Published: January 2025

Link of Video Abstract: https://youtu.be/6pIvxV9ytZs
 
Introduction: Autogenous bone grafting is often required in the reconstruction of extensive calvarial bone defects; however, it comes with limitations that may potentially cause patient morbidity. Recombinant human Bone Morphogenetic Protein-2 (rhBMP-2) has been widely developed for clinical use as a potent osteoblast inductors. The study aimed to prove using a chitosan scaffold combination to accelerate craniofacial bone regeneration, measured by increased osteocalcin expression, number of osteoblasts, formation of woven bone, and PDGF expression.
Method: The study used an experimental post-test-only control group design. Twenty-four male Wistar rats with calvarial bone defects were randomized into four treatment groups (control, rhBMP-2, chitosan scaffold, combination of rhBMP-2, and chitosan scaffold) and observed for four weeks. The resulting data was analyzed using an analytical Package for the Social Sciences (SPSS) software to test the hypothesis.
Result: The results showed the administration of chitosan scaffold, rhBMP-2, and a combination of rhBMP-2 and chitosan scaffold significantly increased osteocalcin expression, the number of osteoblasts, woven bone area formation, and PDGF expression compared to the control group (p<0.05). Significantly higher values (p<0.05) in all parameters were shown in the rhBMP-2 and chitosan scaffold combination group compared to those using chitosan scaffold or rhBMP-2 alone.
Conclusion: This study concluded that administering rhBMP-2 and chitosan scaffold combination accelerated the regeneration of calvarial bone defects in Wistar rats.
Analysis of increased methemoglobin levels in blood after spinal anesthesia using 2% hyperbaric prilocaine compared to 5% hyperbaric lidocaine in elective urological surgery
Authors: Kurniawan Willy , Semedi Bambang Pujo , Santoso Kohar Hari , Sumartono Christrijogo , Kriswidyatomo Prihatma , Lestari Pudji
Published: January 2025

Background: Methemoglobin is an altered state of hemoglobin structure that impairs its ability to transport oxygen. Local anesthesia, especially prilocaine, can induce methemoglobin formation.
Methods: This analytical study employed an experimental single-blind randomized control trial design. A total of 40 subjects aged 18-65 years, with PS ASA I-II, undergoing urological surgery under spinal anesthesia, were included. They were randomly divided into two groups: Group A received hyperbaric lidocaine 5% (75 mg), and Group B received hyperbaric prilocaine 2% (60 mg). Two subjects from each group experienced block failure. Venous blood was drawn from all subjects before, 4 hours, and 8 hours after spinal anesthesia and methemoglobin levels were measured using the ELISA method.
Results: There was no significant difference in methemoglobin levels 4 hours and 8 hours after spinal anesthesia in both groups. The increase in methemoglobin levels 4 hours after spinal anesthesia in the prilocaine group was higher than that of the lidocaine group but not statistically significant. Methemoglobin levels 8 hours after spinal anesthesia began to decrease but remained higher than basal conditions. There were significant differences in methemoglobin levels between basal and 4 hours and between basal and 8 hours in both prilocaine and lidocaine groups.
Conclusions: Blood methemoglobin levels 4 hours and 8 hours after spinal anesthesia with 2% hyperbaric prilocaine were not significantly different from 5% hyperbaric lidocaine. The increase in blood methemoglobin levels 4 hours and 8 hours after spinal anesthesia with 2% hyperbaric prilocaine is not significantly different from 5% hyperbaric lidocaine
The immediate effect of gastrocsoleus muscle stretching with proprioceptive neuromuscular facilitation method on plantar pressure-time integral in patients with diabetes mellitus type 2
Authors: Aritonang Ricky Shubhan , Pawana I Putu Alit , Wardani Nurul Kusuma , Budi Budi
Published: January 2025

Link of Video Abstract: https://youtu.be/5x5OcSCZI0w
 
Background:  The purpose of this study is to look at the immediate effect of gastrocsoleus muscle stretching with the proprioceptive neuromuscular facilitation (PNF) method on plantar pressure-time integral (PTI) in patients with type 2 diabetes mellitus.
Methods: PNF stretching was used using hold relax agonist contraction (HR-AC) to stretch the gastrocsoleus muscle of seventeen diabetes mellitus patients who took part in this study. Stretching was done three times, with a 10-second hold, 6-second contraction, and 10-second hold. Hindfoot, midfoot, forefoot, big toe, and toes pressure-time integral during gait were measured and computed both before and after stretching.
Results: The pressure-time integral in the midfoot, big toe, and toes (p<0.05) was decreased, with a large effect size (r =0.53) in the big toe area. However, the pressure-time integral in the hindfoot and forefoot was increased (p>0.05).
Conclusion: PNF method stretching of gastrocsoleus muscle reduced pressure-time integral in the midfoot, big toe, and toes, and also may be an effective exercise to prevent and treat diabetic foot ulcers
Mortality of COVID-19 patients who underwent tracheostomy at Dr. Soetomo General Hospital, Surabaya
Authors: Zainuri Mohammad Maksum , Wibowo Marjono Dwi
Published: January 2025

Introduction: The elevated incidence of unsuccessful ventilator weaning and endotracheal extubation in COVID-19 patients indicates the necessity of tracheostomy. Tracheostomy can expedite the weaning process and decrease the occurrence of problems. The author aims to investigate the frequency of death among COVID-19 patients who received tracheostomy to determine the potential benefits of tracheostomy in treating COVID-19, particularly in facilitating the transition from mechanical ventilation to reducing airway problems.
Method: This study is a cross-sectional observational analytic descriptive study. Data were taken from the medical records of COVID-19 patients who underwent tracheostomy insertion surgery at RSUD Dr. Soetomo Surabaya in the period January 2022 - December 2023
Results: Of the 50 patients who underwent tracheostomy, 33 patients (34%) were female, and 17 patients (66%) were male, with an average patient age of 20.7 years and, the youngest age was 1 year, the oldest age was 77 years. The mean time of tracheostomy insertion in the sample was 3.669 days, with the shortest time of insertion being 1 day and the longest being 22 days. There were 12 patients (24%) who confirmed COVID-19 and 38 patients (76%) who did not confirm COVID-19. A total of 20 patients (40%) were alive after tracheostomy insertion, while 30 patients (60%) died.
Conclusion: The mortality prevalence of COVID-19 patients with tracheostomy treated at Soetomo General Hospital Surabaya from 2022 to 2023 was 60%.
Influence of third-order susceptibility on electromagnetically induced grating in a three-level V-type atomic system
Authors: Nguyen Huy Bang , Dinh Xuan Khoa , Luong Thi Yen Nga , Ho Hai Quang , Nguyen Van Ai , Le Van Doai
Published: January 2025

In addition to the suppressed absorption in the atomic resonance region, an electromagnetically induced transparency (EIT) medium also possess giant nonlinear dispersion which significantly affects the optical properties of the medium. In this work, we study the influence of third-order nonlinear susceptibility on electromagnetically induced grating (EIG) in a three-level V-type atomic medium. By applying stationary perturbation theory to the density matrix equations describing the time evolution of the quantum states of the system, we have found density matrix solutions to the third-order perturbation corresponding to the third-order susceptibility, and found the transmission function for the probe light. Using the Fourier transform of the transmission function, we can obtain the intensity distribution function of the EIG diffraction spectrum as a function of laser parameters and the atomic medium. To see the influence of third-order susceptibility on EIG diffraction spectrum, we have simulated EIG spectra in two cases with and without third-order susceptibility. We found that the first-order diffraction efficiency was significantly enhanced when third-order susceptibility was introduced.
Motivational profiles for choosing special education teaching as a career
Authors: Valdenegro-Fuentes Lidia , González-Sanzana Álvaro
Published: January 2025

With the research reported on here we investigated the motivation of pre-service special education teachers to choose special education as major. The participants were 332 pre-service teachers from 10 universities in Chile. A latent profile analysis with 5 motivational factors of the factors influencing teaching (FIT)-choice scale was carried out to determine the motivational profiles of special education pre-service teachers. Findings show 3 profiles solution as the best model. The disenchanted profile shows low scores for all the motivational factors included in the study. A group of pre-service teachers displayed the highly engaged profile with very high motivational variables. The conventional profile had high scores in the social utility value, intrinsic value, and self-perceptions factors, although the performance in all of them was like that of the other profiles. Knowing the motivational profiles to choose a special education teaching programme can inform policies to attract and retain special education teachers in the field.
Developing educational communicative effectiveness of a peer relationship scale
Authors: Kalavasonlu Afet , Akcamete Gonul
Published: January 2025

In reviewing existing literature, scales that deal with peer relations’ communicative effectiveness dimension within an educational context were not found. The purpose with this research was to develop a scale for communicative effectiveness of peer relationships for students. A total of 670 students from public/private high schools in Northern Cyprus were selected for this purpose. Using the high school education system in Northern Cyprus, results of scale validity and construct validity tests successfully validated the instrument for “communicative effectiveness of friend relationships.” Cronbach’s alpha coefficient of 0.835 confirmed the validity and reliability of the instrument used in the study. From the results of the exploratory factor analysis, this research provides an instrument with 10 different dimensions to predict the educational communication effectiveness of students. The study validated and loaded 10 of the 42 items. As a result, the findings demonstrate that the peer interaction scale developed in this study was appropriate for gauging high school students’ overall communicative effectiveness.
Artifacts of analysis in cell line identification by short tandem repeat profiling
Authors: Malchenkova A. A. , Kosobokova E. N.
Published: January 2025

Aim. To study and describe the most common types of artifacts in detection of short tandem repeat (STR) amplicons by capillary electrophoresis and cause difficulties in interpreting the obtained STR profiles.

Material and methods. Cell lines were obtained from the bioresource collection of cell lines of the Blokhin National Medical Research Center of Oncology. DNA was isolated according to the manufacturer’s instructions of the DNeasy Blood & Tissue (QIAGEN, Germany) and ExtractDNA Blood & Cells (Evrogen, Russia) kits. DNA concentration was measured using a Qubit 4.0 device (Thermo Fisher Scientific, USA) and a Qubit dsDNA BR Assay Kit (Thermo Fisher Scientific, USA). Multiplex PCR was performed using a COrDIS EXPERT26 reagent kit (Gordiz, Russia). Capillary electrophoresis of PCR products was performed on a 3500xL Genetic Analyzer (Applied Biosystems, USA). GeneMapper Software v6.0 (Thermo Fisher Scientific, USA) was used to process electrophoresis data.

Results. The most well-known artifacts associated with the STR profiling and subsequent capillary electrophoretic separation of amplicons were studied. Cases of detection of these artifacts from personal practice are given. Recommendations for improving the electrophoresis pattern are given.

Conclusion. The paper studies the artifacts of analysis in cell line STR profiling by capillary electrophoresis (STR-CE), which researchers encounter in laboratory practice. Common types of analysis artifacts that cause difficulties in interpreting the results obtained during STR profiling, as well as possible reasons for their occurrence, are described in detail and illustrated with examples from our own practice. Recommendations are given for reducing the number of non-specific fluorescent signals and their intensity.
Biobanks in cardiovascular disease research
Authors: Gusakova A. M. , Kravchenko E. S. , Suslova T. E. , Popov S. V. , Boshchenko A. A.
Published: January 2025

A systematic review of publications from the PubMed and eLibrary. ru databases, Biobanking and Biomolecular Resources Research Infrastructure — European Research Infrastructure Consortium (BBMRI-ERIC) and ClinicalTrials.gov studies was carried out for 15 years. The aim was to find priority areas for the use of biobanks in cardiology. The key areas of research on blood and heart tissue biobanks are the study of pathogenetic mechanisms, creation of innovative methods for diagnosis, treatment and prevention of cardiovascular diseases (CVDs). The use of modern technologies such as genomics, transcriptomics, proteomics and metabolomics allows identifying candidate markers, revealing new molecular targets for drug therapy, diagnostic and therapeutic approaches for CVD. One of the promising areas is the search and study of polygenic scores of CVD risk and predictors of adverse cardiovascular events. Analysis of the registry revealed another important area of biobank application — clinical trials, in which biobanks are a key resource of blood and tissue samples, as well as clinical, paraclinical, and socio-demographic data. Therefore, studies using biobank resources are necessary to study the pathogenetic mechanisms of CVD, identify new proteomic biomarkers and genetic factors, as well as to improve diagnostics, prevention and treatment.
Creation of a plasma collection for the search of diagnostic biomarkers of glial tumors
Authors: Omelchuk E. P. , Timoshkina N. N. , Gvaldin D. Yu. , Petrusenko N. A. , Rostorguev E. E. , Novikova I. A. , Kit O. I.
Published: January 2025

Aim. To create a collection of plasma samples of patients with brain tumors (BTs) for the development of a diagnostic microRNA (ribonucleic acid) panel of glial tumors.

Material and methods. Plasma samples of patients with benign and malignant BTs were obtained by double centrifugation of whole blood and then frozen at -75оС.Fifty-nine RNA samples isolated from blood plasma were analyzed by next-generation sequencing (NGS).

Results. Currently, the biobank contains samples from 339 patients with primary and secondary BTs and 10 control group individuals (698 samples — 2 plasma aliquots per individual), including 143 men and 206 women. The age of the patients ranged from 19 to 91 years (median — 56 years). Primary BTs (41%) included two following groups: benign (33,7%) and malignant (66,3%). Meningiomas constituted the bulk (91%) of the benign BTs. Among the malignant tumors, glioblastomas (46,7%) and astrocytomas (41,6%) prevailed, while oligodendrogliomas and ependymomas accounted for only 9,1 and 2,5%, respectively. Secondary BTs (59%) are represented by recurrent glial tumors (92,5%) and metastatic tumors (7,5%) of lung cancer (71,4%) and breast cancer (28.6%). A protocol for the primary preparation of liquid biopsy samples was implemented, which made it possible to obtain high-quality deoxyribonucleic acid libraries for the selected microRNA profiling platform.

Conclusion. The creation of a plasma sample collection is the basis for searching circulating biomarkers of BTs.
Creation of a cell culture bank: experience of the Pokrovsky Cell Technology Center
Authors: Prikhodko E. M. , Supilnikova O. V. , Maslennikova I. V. , Yenukashvili N. I. , Kotova A. V. , Bagaeva V. V. , Zolina T. L. , Konkina A. I. , Atsemirsky G. S.
Published: January 2025

Modern research in cell biology places high demands on the model objects used, including cell cultures. These requirements are dictated by the need to avoid artifacts in work and reduce potential risks to the environment associated with biological hazard. The article presents the experience of creating cell culture bank for personal and public storage at the Pokrovsky Cell Technology Center. The main points of managing the collection, incoming quality control, certification, processing, preparation for storage and storage of human biological materials are considered. The developed approaches and work algorithms made it possible to create a collection of early passage cultures consisting of certified samples that meet the requirements for cell cultures for the manufacture of high-tech drugs and biomedical cell products, as well as for research.
Lipoprotein transport and metabolism markers in patients with myocardial infarction in the Biobank of Yugra blood sample collection
Authors: Vorobyov A. S. , Donnikov M. Yu. , Glotov O. S. , Kovalenko L. V. , Nikolaev K. Yu. , Urvantseva I. A. , Drenina Yu. A. , Morozkina A. V. , Chernysheva G. N.
Published: January 2025

Aim. To evaluate clinical associations and predictive value of lipoprotein transport and metabolism markers determined in a collection of serum samples from patients with myocardial infarction (MI).

Material and methods. Collection of blood samples from 88 patients with the acute MI was created in the Biobank of Yugra laboratory for subsequent biochemical assessment of serum levels of lipoprotein transport and metabolism markers. All patients were included in a clinical prospective study for 48 months with registration of medical events and remote tomographic assessment of coronary artery (CA) involvement upon follow-up completion.

Results. Direct associations were established between proprotein convertase subtilisin/kexin type 9 (PCSK9) levels and low-density lipoprotein cholesterol levels, coronary atherosclerosis, Global Registry of Acute Coronary Events (GRACE) 2.0 risk score, and the risk of recurrent acute coronary syndrome. Lipoprotein (a) levels >50 mg/dl were detected in 28,4% of patients with MI and were associated with prior medical events, coronary and non-coronary artery atherosclerosis, comorbidity, recurrent coronary lesions, and the risk of major cardiac events at the end of follow-up. A relationship was established between a high (5,14) triglyceride-glucose index and comorbidity, recurrent coronary lesions, and the death risk at the end of follow-up.

Conclusion. The Biobank of Yugra laboratory is an effective base for laboratory research. Lipoprotein transport and metabolism markers are associated with clinical factors, comorbidity, vascular atherosclerosis and a negative prognosis in patients with MI.
Effect of plasma and serum storage conditions on circulating microRNA levels
Authors: Sotnikova E. A. , Kiseleva A. V. , Meshkov A. N.
Published: January 2025

Over the past decade, circulating small non-coding ribonucleic acid molecules (microRNAs) have demonstrated their potential as minimally invasive diagnostic and prognostic biomarkers of various diseases. Standardization of preanalytical and analytical factors, including collection, processing and storage of biosamples, plays a significant role in the reliability and reproducibility of circulating microRNA quantification. To date, there is no consensus regarding the data normalization used in the analysis of circulating microRNA expression. The review aim is to consider modern original papers on various storage conditions of biobanked plasma and serum samples with subsequent isolation of circulating microRNAs for analysis.
Bioinformatics approach to processing data from high-throughput sequencing of small RNA molecules
Authors: Zharikova A. A. , Vyatkin Yu. V. , Kiseleva A. V. , Meshkov A. N.
Published: January 2025

High-throughput sequencing of small ribonucleic acid (RNA) molecules is widely used to search for markers of various diseases, as well as to study the regulation of gene expression. The data processing protocol consists of many stages, including the stages of analyzing the initial data quality and sequencing results, mapping and studying the expression profile of the detected small RNA molecules. A whole arsenal of programs and specific packages has already been developed to implement each study step. The instrumental composition of the final bioinformatics protocol is critically important for the correct data processing and study reproduction. This review describes the most universal protocol for processing the results of high-throughput sequencing of small RNA molecules, including all the main stages and the most widely used programs.
Laporan Kasus: Manajemen Anestesi Operasi Caesar pada Wanita Usia 30 Tahun dengan Preeklampsia Berat dengan Hipertensi Pulmonal Probabilitas Tinggi
Authors: Hermawan Andi , Kurniawan Adi
Published: January 2025

Ibu hamil dengan hipertensi pulmonal (HP) memiliki peningkatan risiko yang signifikan untuk dapat mengalami ketidakstabilan hemodinamik, gagal jantung, sepsis pascaoperasi, dan gagal napas. Kehamilan pada ibu dengan hipertensi pulmonal merupakan kehamilan risiko tinggi sehingga diperlukan perencanaan yang baik dan pendekatan tim multidisiplin. Kehamilan dengan hipertensi pulmonal memerlukan manajemen anestesi yang tepat untuk mencapai hasil klinis ibu dan janin yang optimal. Laporan kasus ini menggambarkan manajemen anestesi yang telah dilakukan pada wanita multigravida berusia 30 tahun dengan preeklampsia berat dan kemungkinan besar menderita HP. Teknik yang digunakan dengan anestesi epidural total. Operasi berlangsung selama 2 jam dan pendarahan sebanyak 250 m. Setelah operasi, pasien dirawat di ICU. Di ICU, keadaan pasien memburuk sehingga dilakukan intubasi dan ventilasi terkontrol. Pasien mengalami serangan jantung dan diresusitasi. Pasien meninggal 3 jam setelah masuk ICU. Hal yang perlu diwaspadai dalam penanganan pasien hipertensi pulmonal adalah pemantauan intensif pascaoperasi untuk memantau dan mengantisipasi terjadinya krisis hipertensi pulmonal yang dapat menyebabkan kematian.
KORELASI ANTARA DOPPLER-BASED RENAL RESISTIVE INDEX DAN NILAI KREATININ PADA PASIEN SAKIT KRITIS
Authors: Tanto Dedi , Pradian Erwin , Erlangga Erias
Published: January 2025

Indeks resistriksi renal/renal resistive index (RRI) merupakan pemeriksaan ultrasonografi non invasif untuk menilai renovascular dan dapat dilakukan dengan prinsip point-of-care testing (POCT) RRI merefleksikan perubahan aliran darah arteri intrarenalis, yang dapat terganggu pada pasien dengan gangguan fungsi ginjal, yang tercermin dalam peningkatan nilai kreatinin serum. Penelitian ini bersifat observasional analitik dengan desain potong lintang, bertujuan untuk mengetahui hubungan antara RRI dan nilai kreatinin serum pada pasien sakit kritis di ICU RSUP Dr. Hasan Sadikin, Bandung, dari Mei hingga Agustus 2023. Sebanyak 51 pasien berusia 18–65 tahun menjalani pemeriksaan RRI dan kreatinin serum pada 24 jam pertama dan kedua setelah masuk ICU. Analisis korelasi menunjukkan nilai R sebesar 0,538, koefisien determinasi (r²) sebesar 0,298, dan nilai p<0,001. Hasil ini menunjukkan korelasi positif moderat antara RRI dan nilai kreatinin serum.
PERBANDINGAN TEKNIK PEMASANGAN PIPA NASOGASTRIK ANTARA MANUVER REVERSE SELLICK DENGAN MANUVER FLEKSI LEHER TERHADAP ANGKA KEBERHASILAN DAN DURASI WAKTU PEMASANGAN PADA PASIEN TERINTUBASI DI RSUP DR. HASAN SADIKIN BANDUNG
Authors: T. Maskoen Tinni , Budipratama Dhany , Nasution Muhammad Habibi
Published: January 2025

Pemasangan pipa nasogastrik (NGT) penting dilakukan pada beberapa pembedahan dan pada pasien di ruang rawat intensif (ICU). Pemasangan NGT menjadi sulit pada pasien terintubasi dan paling sering tertahan pada sinus priformis, kartilago aritenoid, dan esofagus yang tertekan oleh balon ETT. Manuver reverse Sellick merupakan teknik yang dilakukan dengan cara menggenggam kartilago krikoid lalu diangkat ke arah anterior dan manuver fleksi leher merupakan suatu cara menekukkan leher pasien semaksimal mungkin pada saat memasang NGT. Penelitian ini menggunakan metode prospektif analitik komparatif eksperimental dengan rancangan randomized clinical trial single blind study. Penelitian telah dilakukan di RSUP Dr. Hasan Sadikin Bandung (RSHS) terhadap 94 subjek. Analisis statistik data kategorik menggunakan Uji Chi Square dan uji normalitas dengan menggunakan Kolmogorov smirnov. Hasil uji statistik perbandingan tingkat keberhasilan pada kelompok manuver reverse Sellick dan kelompok manuver fleksi leher adalah 85,1% dan 74,5% dengan perbedaan yang tidak bermakna (p>0,05). Durasi pemasangan NGT pada kelompok manuver reverse Sellick dan kelompok manuver fleksi leher adalah 13,499±1,571 detik dan 20,5,06±3,051 detik dengan perbedaan signifikan (p<0,05; Tabel 2). Simpulan tingkat keberhasilan pada kelompok manuver reverse Sellick memiliki angka keberhasilan yang tidak berbeda signifikan dibanding dengan kelompok manuver fleksi leher. Durasi pemasangan dari kelompok manuver reverse Sellick lebih singkat dibanding dengan kelompok manuver fleksi leher.
Effect of drains layout density on consolidation of layered slurry induced by PHDs-VP
Authors: Yang K. , Lu M. , Geng X. , Wang G.
Published: January 2025

Prefabricated horizontal drains (PHDs) combined with vacuum preloading (VP) presents distinct advantages over prefabricated vertical drains (PVDs) and has become a popular method for the treatment of dredged slurry. However, the effect of drains layout density on the consolidation characteristics of slurry has not been extensively investigated. This study addresses this gap by conducting three groups of experiments using the layered filling approach, one of which focused on the PHDs-PVDs-VP method. Throughout the consolidation process, water discharge and surface settlement were monitored. Post-consolidation, soil properties were assessed and shapes of prefabricated drains were examined. The results indicate that increased drains layout density accelerates consolidation rate. Additionally, using the layered filling approach can increase the treatment capacity of disposal sites by 25%, enhance the reinforcement effectiveness of deep soil layer, and achieve more uniform settlement. Moreover, the PHDs-PVDs-VP method can enhance the treatment effectiveness of slurry without the requirement for a substantial increase in drains layout density. These insights into the dewatering and reinforcement mechanisms offer valuable guidance for practical engineering applications.
Building a system of dynamic norms for evaluating the functioning of complex systems on the example of the regions of the Central Federal District
Authors: Zhukov Roman , Prokopchina Svetlana , Plinskaya Maria , Zhelunitsina Maria
Published: January 2025

In this paper, we present a method of forming norms for evaluating the results of the functioning of complex systems applicable to socio-ecological and economic systems, taking into account the priorities of the development of the regions of the Russian Federation. The methodology involves the selection of normative values from a set of norms based on two methods: the first is based on the construction of econometric models using statistical data for a set of subjects (the first type) and for one selected subject (the second type). The second method uses the methodology of Bayesian intelligent measurements based on the regularizing Bayesian approach (the third and fourth types). Depending on the result of the calculations, a norm is selected that gives a higher (in the case of high priority), average (in the case of medium priority) and lower (in the case of low priority) normative value of the evaluated effective features characterizing the development of the subject. The implementation of the method is demonstrated by the example of the regions of the Central Federal District, including the Tula Region, for which econometric and fuzzy models of the relationship between the volume of gross regional product with the value of fixed assets and the number of employees for sections A (Agriculture, forestry, hunting, fishing and fish farming) and C (Mining) according to OKVED1 are constructed, forming the raw materials sector according to data for 2007–2022. The EFRA and Infoanalyst 2.0 software platforms are used as tools. The results obtained can be used by regional authorities in the formation of norms to assess the results of the functioning of the regions in the short and medium term.
Pelaksanaan Program Bimbingan Baca Tulis Berbantuan Media Let’s Read dalam Meningkatkan Kemampuan Membaca Siswa Kelas 1 SD
Authors: Mawanti Adinda Putri , Dani Alma Kumala , Nursofia Fifin , Latifah Nilna Umi , Widodo Trio , Nurmitasari Zulvia Lely , Sutarno Sutarno , Ismayati Yustika Dwi
Published: January 2025

Tujuan dari penelitian ini yaitu untuk meningkatkan kemampuan membaca siswa kelas 1 di SDN Bareng 3 Kota Malang. Membaca merupakan kegiatan penting yang dilakukan seseorang dalam kehidupan sehari-hari. Tetapi pada saat ini kemampuan membaca tingkat sekolah dasar di Indonesia dapat dikatakan rendah. Salah satu upaya yang dapat dilakukan adalah memberikan perhatian khusus kepada peserta didik yang mengalami kesulitan membaca. Metode penelitian yang digunakan adalah kualitatif deskriptif. Teknik pengumpulan data pada penelitian ini adalah observasi, wawancara dan dokumentasi. Teknik analisis data meliputi reduksi data, penyajian data dan penarikan kesimpulan. Penelitian ini dilakukan di Kelas 1 SDN Bareng 3 Kota Malang. Hasil dari penelitian ini adalah data mengenai faktor yang melatarbelakangi rendahnya kemampuan membaca siswa tingkat sekolah dasar adalah (1) faktor dari dalam diri peserta didik (2) kurangnya perhatian dari orangtua (3) kondisi fisik peserta didik. Dengan demikian, terdapat upaya yang dapat dilakukan untuk meningkatkan kemampuan membaca peserta didik yaitu melalui program bimbingan belajar dengan berbantuan platform let’s read.
The exploration of the use of placenta in Diabetic Ulcer Disease: A Systematic Review
Authors: Arezina Daniela , Li Dan
Published: January 2025

This paper seeks to provide a comprehensive review of the utilization of placental tissue therapies in addressing the challenges posed by diabetic foot ulcers (DFUs). A systematic review approach was employed, utilizing the PubMed database to identify relevant research papers. Following the initial search, a rigorous screening process was undertaken, comprising two rounds of screening to ensure the inclusion of relevant studies. The review showed that placental tissue therapies are effective for diabetic foot ulcers (DFUs). They can be applied topically, injected, or implanted, leading to faster wound healing and tissue regeneration. Studies found quicker closure of wounds, shorter healing times, and better outcomes with these treatments. Placental tissues contain mesenchymal stem cells and growth factors, making them effective for diabetic foot ulcers management. They offer a promising way to speed up wound healing and enhance patient outcomes. Further research is warranted to validate these findings and explore optimal treatment protocols for maximizing the therapeutic benefits of placental tissue therapies in diabetic foot ulcers management.
Fibromyalgia: Another Aetiological Approach
Authors: Marc Golstein
Published: January 2025

Fibromyalgia and diffuse pain disorders have been the subject of thousands of specialised publications and more than 56,000,000 references suggested by public search engines.

Nevertheless, the aetiology of diffuse pain syndrome remains poorly understood, though it accounts for nearly 20% of rheumatology consultations. Treatment is not very systematised and the results of treatment procedures remain of limited efficacy in terms of work capacity. The socio-economic consequences for patients with fibromyalgia are on the same level as those seen in patients diagnosed with rheumatoid arthritis. It would appear desirable to review the aetiological approach to be able to treat diffuse pain disorders more effectively. The association between violence experienced during childhood and the onset of fibromyalgia has been previously suggested without being considered a necessary and sufficient cause. However, thanks to the development of medical brain imaging techniques and the knowledge of epigenetic mechanisms, it seems that a previous history of sexual abuse and physical violence experienced during childhood could effectively be one of/or the cause of the onset of fibromyalgia.
Propiedad industrial e innovación. Los certificados de invención en México establecidos entre 1976 y 1991
Authors: Campa-Navarro Juan Ignacio
Published: January 2025

Este trabajo estudia los certificados de invención, una figura legal de propiedad industrial establecida en México durante el último cuarto del siglo pasado, con el fin de examinar su papel como un instrumento establecido para incentivar principalmente actividades de innovación tecnológica y desarrollo productivo dentro del territorio nacional. Con base en una revisión exhaustiva documental y mediante un análisis descriptivo de ciertos datos estadísticos, mostramos que los certificados de invención no contribuyeron al desarrollo dinámico e intensivo de las actividades de divulgación e innovación local, en especial las provenientes de mexicanos o nacionales, cuestión que era el objetivo principal de la política de patentes en general y de los certificados de invención en particular. Esto se debió a que los incentivos establecidos por el entramado institucional provocaban más incertidumbre que certeza a los actores nacionales para registrar y usar certificados de invención productivamente.
Automatic Pill Dispenser for Mines and Metal Industry Patients
Authors: Archana A. , Muneedra N. , Sekhar Velappagari , Renuka K.
Published: January 2025

Medication has the potential to both prolong life and allow people to work efficiently in the mines. For many people, medication regimes can become complex and daunting. Poor medication Adherence can be detrimental to one's self-esteem and well-being. Health and social care agencies must intervene and assist people before complex, costly, and intensive interventions such as hospitalisation become necessary. For the individual, this necessitates straight forward and easy-to-access assistance. This programme connected local governments, PCT clusters, and community pharmacies. Almost 400 persons have profited from the service of an Automated Pill Dispenser, which has assisted them in self-managing their medication. This report outlines both the business case and qualitative data about people's experiences with the West Midlands Autonomous Pill Dispenser programme. Municipalities and the federal government have taken on increased responsibilities for grassroots healthcare this work becomes increasingly important. Many health problems people facing in the mining sector which is operated remotely can be reduced by using this kind of automated pill dispenser.
Influence of Rice Husk Reinforced Material to Analyse Thermal and Fire Retardant Properties
Authors: Sridhar B. S. , Harish Gowda H. S. , Revanth G. , Siddaling  , Cunha Josiah D. , Shashikala A. R.
Published: January 2025

Natural fibers derived from agricultural waste have gained significant recognition in the polymer industries with more benefits, including their lightweight nature, cost-effectiveness, and eco-friendliness. Presently, there has been a growing emphasis on utilizing natural fibers as materials for fiber composites, driven by increasing environmental concerns. One such natural fiber of interest is Rice Husk (RH), which is the protective sheath that surrounds rice grains during their growth. Rice husk, being an agricultural waste, has emerged as a promising natural fiber for the development of bio-composites. The outer surface of the husk is covered with a silica layer, while the innermost epidermis contains a minimal amount of silica content. The utilization of rice husk residues in the production of bio-composites offers several advantages, such as reducing the dependence on synthetic polymers, including resin polymers and certain additives. This approach contributes to a more sustainable and environmentally conscious manufacturing process. This research concentrated on the influence of rice husk material on the structural, thermal, flammable, and mechanical properties. The thermal properties were characterized using Thermogravimetric Analysis (TGA). An automobile interior dashboard design is synthesised with a material keeping cost and price as the prime factor along with its strength, the structure is strengthened against an external force applied.
Optoelectronic Properties of 4,6-Dihydro-5H-Thieno [2,3-B]Pyrrol-5-One Based Conducting Polymers for Photovoltaic Applications
Authors: Pai Maya M. , Yallur Basappa C. , Patil Archana R. , Adimule Vinayak M. , Batakurki Sheetal R.
Published: January 2025

Energy materials have great demand in the global energy market today. Renewable sources of energy materials are sustainable sources of energy materials that have many advantages over traditional materials. Metal-based solar cells are first-generation materials that are commercialised due to their high efficiency. However, the high cost of these materials hinders their wide applications. In recent times organic polymers have attained a lot of interest due to their low cost, flexibility and broad absorption. This research reports a new polymer (4Z)-4-(thiophene-2- ylmethylidene)-4,6-dihydro-5H-thieno[2,3-b] pyrrole-5-one synthesised using Aluminium substituted catalyst which achieved high yield at ambient temperature. Separate polymerisation of the produced monomer was done using thiophene functionalised with bis (trimethylstannyl) to get polymer P1 which showed broad absorption in UV-visible region between 620 to 625nm showing Highest Occupied Molecular Orbital (HOMO) energy levels that are low lying. The heterojunction solar cells based on the new polymers were fabricated and tested. Based on the novel polymer, the solar cell devices demonstrated a remarkably high power conversion efficiency of 6.6%, an open circuit voltage (VOC) of 0.63, a fill factor of 0.52 and a short circuit current density (Jsc) of 6.3. For Polyvinyl Chloride (PVC) applications, the produced polymers are hence promising candidates. Furthermore, future studies involve doping of suitable metals like copper and samarium to the polymer to enhance the efficiency of the photovoltaic cells.
Effect of Viscous Dissipation and Thermal Radiation on Thermal Properties of MHD Nanofluid in a Curved Channel
Authors: Kavitha C. , Neeraja Gullapalli , Gayathri N. S. , Patel Sudhir
Published: January 2025

The effects of radiation and magnetohydrodynamics on the peristaltic flow of a nanofluid through a porous media in a two-dimensional circular asymmetric channel have been theoretically analysed in terms of viscous dissipation. Under the assumption of a radially uniform magnetic field, the nanofluid is electrically conducting. The radiation response, thermophoresis, and Brownian motion are all taken into consideration by the transport equation. The assumptions of a long wavelength and a low Reynolds number have further simplified the problem. The impact of many parameters on the flow characteristics has been examined through graphical representations using MATLAB bvp4c. Further, impact of Nusselt and Sherwood numbers are studied and its effects are displayed through graphs. Also impact of Schmidt and Soret numbers are examined.
Combined Effect of Viscous Dissipation and Forchheimer Drag on 3D Nanofluid Flow over Nonlinear Stretching Sheet
Authors: Manoharkumar K. N. , Patil Shalini M. , Dinesh P. A. , Suma K. V.
Published: January 2025

Present study investigates the impact of viscous dissipation and drag force on 3D – Darcy Forchheimer nanofluid flow over flat surface induced by bi-directional power law stretching sheet. Inflated flow rate in the considered region is encountered by velocity square in the momentum equation. The principal model is represented as highly nonlinear homogenous ODE. By using suitable similarity transformation PDE is modified into dimensionless ODE which is then tackled by RKF-NR approach. The computational results are depicted through graphical representation on velocity, temperature and concentration for various range of nondimensional physical components such as Schmidt, Eckert, Prandtl and Forchheimer numbers. Outcomes of the current findings has found various applications in industry viz solar energy, crystal growth and metal working processes. Results are in good agreement upon comparing with the earlier studies.
A Numerical Study of Oblique Stagnation Point Flow of Ternary Nanofluid over a Stretching Sheet
Authors: Pradeep Vinay C. , Chakravarthy Y. S. Kalyan , Mallikarjuna B.
Published: January 2025

A mathematical model has been developed to investigate the heat transfer enhancement due to the ternary nanofluid (Cu/Fe3O4/SiO2-Polymer) flow past a stretching sheet. A time-independent two-dimensional oblique stagnation-point flow was considered. The governing equations for the conversion of mass, momentum and energy along with the boundary conditions were transformed into dimensionless equations using relevant non-dimensional variables. The obtained set of equations was reduced to ordinary differential equations using similarity transformations. A numerical technique was used to find the solution and validate the attained results with the existing literature in a limiting case. The solutions were presented graphically for fluid velocity and temperature for various volume fractions of the nanoparticles. The results were analysed for different cases of nanofluid, hybrid nanofluid and ternary nanofluid.
Different Variants of the Nirmala Index and their Applications
Authors: Sharma Girish , P. S. Venkatesh , K. S Ramesh Kumar , T. L. Venu
Published: January 2025

Applications of graph theory include everything from arranging tournament games to analysing the structure of proteins. The Quantitative Structure-Property Relationship (QSPR) and the Quantitative Structure-Activity Relationship are current trends in graph theory (QSAR). The use of degree-based topological indices for QSPR and QSAR has been the subject of numerous publications. This study generalises a newly introduced distance-based topological index and uses the topological index to determine the boiling points of a particular family of aromatic compounds. This work also presents a unique way to determine the critical temperature of alkanes.
B-Semi Symmetric Properties on Lorentzian α Sasakian Manifolds
Authors: Somashekhara P. , Praveena M. M. , Siddesha M. S.
Published: January 2025

We study B-semi symmetric, B-pseudo-symmetric, Ricci-pseudo-symmetric and B-Ricci generalized pseudo-symmetric of Lorentzian α-Sasakian Manifolds and additionally, we provide conditions that determine whether the solutions of the Ricci flows manifest as steady, expanding, or shrinking.