bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemistry of azo-imine based palladium complexes: a brief review
Authors: Mandal Paritosh , Pratihar Jahar L.
Published: September 2022

This paper provides a general overview of palladium complexes incorporating numerous multidentate azo-imine ligands, their structural diversity, synthetic protocol, interesting properties such as redox properties, biological activity and their further application on C – N coupling reactions, C – C cross-coupling reactions (e.g., Suzuki and Heck) and catalytic activity on different organic transformations. A detailed literature survey revealed that no brief review has yet been published on the azo-azomethine-based palladium complex. Therefore, the present review incorporates the research undertaken on the synthetic strategies and coordinating behaviour of various azo-imine ligands with palladium metal centre and a few important properties of metal complexes.
On determination of the number of factors in an approximate factor model
Authors: Liu Jinshan , Pan Jiazhu , Xia Qiang , Xiao Li
Published: September 2022

This paper proposes a ridge-type method for determining the number of factors in an approximate factor model. The new estimator of factor number is obtained by maximizing both the ratio of two adjacent eigenvalues and the cumulative contribution rate of the factors which represents the explanatory power of the common factors for response variables. Our estimator is proved to be as asymptotically consistent as those in (Ahn, S., and A. Horenstein. 2013. “Eigenvalue Ratio Test for the Number of Factors.” Econometrica 81: 1203–27). But Monte Carlo simulation experiments show our method has better correct selection rates in finite sample cases. A real data example is given for illustration.
Short and Long Term Impacts and Implications of Fetal Alcohol Syndrome Disorders on Cognitive Development in Childhood
Authors: Chow Selina , Farcas Sophia , Ghazi Urwa , Huang Emma , Liu Ya Jing
Published: September 2022

Fetal alcohol syndrome disorders (FASD) represent a collection of disorders with which a child is born, due to maternal consumption of alcohol during pregnancy. Known as an invisible disability, its prevalence is difficult to capture, in part due to societal stigma and the lack of physical markers contributing to diagnostic difficulty. In Canada, FASD prevalence is estimated to be around 4%. The symptoms experienced by a child with FASD are typically classified into two categories: primary disabilities to describe functional deficits since birth as a result of the impact of alcohol on the brain; and secondary disabilities that occur later in life as a result of a child’s environment and primary disabilities. The impacts of FASD will affect each child differently in both the types and severity of disabilities. A major challenge faced by children and youth with FASD is receiving adequate mental health support, as well as evidence-informed practices involved in improving behavioural and cognitive functioning. COVID-19 has dramatically affected both children with FASD and their caregivers, likely exacerbating existing challenges. With increased rates of alcohol consumption and other mediating factors, experts are concerned about rising FASD rates during the pandemic.
Effect of Silicon Element on the Solid Solubility of Carbon in α-Fe
Authors: Wang Tiemin , Zhang Lei , Su Fuyong , Wen Zhi , Tao Shuming
Published: September 2022

The VASP (Vienna Ab initio Simulation Package) software package developed by the Hafner team at the University of Vienna was used to calculate the bonding involving the element in the system when silicon is added to a complex of α-Fe and carbon(α-Fe(C)). The interaction energies of silicon with carbon elements in their different neighbor locations in the matrix of α-Fe(C) matrix are obtained, and the electronic structure of a complex composed of α-Fe(C) and silicon(α-Fe(C)-Si) and the interaction between silicon and carbon in the α-Fe matrix are further analyzed. The influence of silicon on the solid solubility of carbon in the α-Fe matrix is analyzed and calculated on this basis. The results show that after a silicon atom is added to α-Fe(C), the silicon atom and iron atoms gain electrons, the carbon atom loses electrons, and bonds among the three are formed. The bonding electrons are mainly provided by iron atoms and the silicon atom. The atomic fraction of carbon element in the range of interaction with the silicon element in the α-Fe(C)-Si system is higher than the average atomic fraction of carbon in the α-Fe(C) system without the silicon element. The results show that the solid solubility of the carbon element in α-Fe increases after the silicon element is added.
Integrity of Neuronal Size in the Entorhinal Cortex Is a Biological Substrate of Exceptional Cognitive Aging
Authors: Nassif Caren , Kawles Allegra , Ayala Ivan , Minogue Grace , Gill Nathan P. , Shepard Robert A. , Zouridakis Antonia , Keszycki Rachel , Zhang Hui , Mao Qinwen , Flanagan Margaret E. , Bigio Eileen H. , Mesulam M.-Marsel , Rogalski Emily , Geula Changiz , Gefen Tamar
Published: September 2022

Average aging is associated with a gradual decline of memory capacity. SuperAgers are humans ≥80 years of age who show exceptional episodic memory at least as good as individuals 20–30 years their junior. This study investigated whether neuronal integrity in the entorhinal cortex (ERC), an area critical for memory and selectively vulnerable to neurofibrillary degeneration, differentiated SuperAgers from cognitively healthy younger individuals, cognitively average peers (“Normal Elderly”), and individuals with amnestic mild cognitive impairment. Postmortem sections of the ERC were stained with cresyl violet to visualize neurons and immunostained with mouse monoclonal antibody PHF-1 to visualize neurofibrillary tangles. The cross-sectional area (i.e., size) of layer II and layer III/V ERC neurons were quantified. Two-thirds of total participants were female. Unbiased stereology was used to quantitate tangles in a subgroup of SuperAgers and Normal Elderly. Linear mixed-effect models were used to determine differences across groups. Quantitative measurements found that the soma size of layer II ERC neurons in postmortem brain specimens were significantly larger in SuperAgers compared with all groups (p< 0.05)—including younger individuals 20–30 years their junior (p< 0.005). SuperAgers had significantly fewer stereologically quantified Alzheimer's disease-related neurofibrillary tangles in layer II ERC than Normal Elderly (p< 0.05). This difference in tangle burden in layer II between SuperAgers and Normal Elderly suggests that tangle-bearing neurons may be prone to shrinkage during aging. The finding that SuperAgers show ERC layer II neurons that are substantially larger even compared with individuals 20–30 years younger is remarkable, suggesting that layer II ERC integrity is a biological substrate of exceptional memory in old age.

SIGNIFICANCE STATEMENTAverage aging is associated with a gradual decline of memory. Previous research shows that an area critical for memory, the entorhinal cortex (ERC), is susceptible to the early formation of Alzheimer's disease neuropathology, even during average (or typical) trajectories of aging. The Northwestern University SuperAging Research Program studies unique individuals known as SuperAgers, individuals ≥80 years old who show exceptional memory that is at least as good as individuals 20–30 years their junior. In this study, we show that SuperAgers harbor larger, healthier neurons in the ERC compared with their cognitively average same-aged peers, those with amnestic mild cognitive impairment, and – remarkably – even compared with individuals 20–30 years younger. We conclude that larger ERC neurons are a biological signature of the SuperAging trajectory.
Variability of the Surface Area of the V1, V2, and V3 Maps in a Large Sample of Human Observers
Authors: Benson Noah C. , Yoon Jennifer M. D. , Forenzo Dylan , Engel Stephen A. , Kay Kendrick N. , Winawer Jonathan
Published: September 2022

How variable is the functionally defined structure of early visual areas in human cortex and how much variability is shared between twins? Here we quantify individual differences in the best understood functionally defined regions of cortex: V1, V2, V3. The Human Connectome Project 7T Retinotopy Dataset includes retinotopic measurements from 181 subjects (109 female, 72 male), including many twins. We trained four “anatomists” to manually define V1-V3 using retinotopic features. These definitions were more accurate than automated anatomical templates and showed that surface areas for these maps varied more than threefold across individuals. This threefold variation was little changed when normalizing visual area size by the surface area of the entire cerebral cortex. In addition to varying in size, we find that visual areas vary in how they sample the visual field. Specifically, the cortical magnification function differed substantially among individuals, with the relative amount of cortex devoted to central vision varying by more than a factor of 2. To complement the variability analysis, we examined the similarity of visual area size and structure across twins. Whereas the twin sample sizes are too small to make precise heritability estimates (50 monozygotic pairs, 34 dizygotic pairs), they nonetheless reveal high correlations, consistent with strong effects of the combination of shared genes and environment on visual area size. Collectively, these results provide the most comprehensive account of individual variability in visual area structure to date, and provide a robust population benchmark against which new individuals and developmental and clinical populations can be compared.

SIGNIFICANCE STATEMENTAreas V1, V2, and V3 are among the best studied functionally defined regions in human cortex. Using the largest retinotopy dataset to date, we characterized the variability of these regions across individuals and the similarity between twin pairs. We find that the size of visual areas varies dramatically (up to 3.5×) across healthy young adults, far more than the variability of the cerebral cortex size as a whole. Much of this variability appears to arise from inherited factors, as we find very high correlations in visual area size between monozygotic twin pairs, and lower but still substantial correlations between dizygotic twin pairs. These results provide the most comprehensive assessment of how functionally defined visual cortex varies across the population to date.
Pengaruh Fasilitas, Pelayanan dan Koleksi Buku terhadap Minat Baca
Authors: Yulianti Yulianti , Rozi Fahrur
Published: September 2022

The purpose of this study was to determine the effect of library facilities, library services, and book collections on the reading interest of class XI students in the library of SMK Negeri 1 Wonosobo either simultaneously or partially. The population in this study were all students of class XI at SMK Negeri 1 Wonosobo totaling 444 students and a sample of 210 students was taken using proportional random sampling technique. Data were collected by questionnaire. Methods of data analysis using descriptive percentage, multiple regression analysis, hypothesis testing F test and t test. The results showed: 1) there was a simultaneous positive and significant effect between library facilities, library services, and book collections on the reading interest of class XI students in the library of SMK Negeri 1 Wonosobo by 65.2%; 2) There is a positive and partially significant effect between library facilities on reading interest in class XI students in the library of SMK Negeri 1 Wonosobo by 8.41%; 3) There is a positive and partially significant effect between library services on reading interest in class XI students in the library of SMK Negeri 1 Wonosobo by 14.5%; 4) There is a positive and partially significant effect between book collections on reading interest of class XI students in the library of SMK Negeri 1 Wonosobo by 19.36%.
Semblanza de Guillermo Vargas Salazar (1947-2014)
Authors: Artavia Álvarez Jorge Alberto
Published: September 2022

Esta semblanza tiene por finalidad presentar una biografía de la vida del Dr. Guillermo Vargas Salazar, el profesor que dio brillo a las aulas, al estudio y a la creación. El político que llega a ocupar espacios en la función pública, para involucrarse en la construcción de una Costa Rica más equitativa, más justa, acorde con los sueños que venía persiguiendo a lo largo de la vida (González, 2014).La semblanza desarrolla una exposición cronológica acotada, que no pretende agotar sus aportes, pero sí dejar claro que sus andanzas siempre tuvieron una meta mayor que el simple placer inmediato, aun cuando concluyó su tesis doctoral expresando: “acti labores iucundi” (Vargas, 2013).
Konsep Dzikir Sebagai Terapi Gangguan Bipolar
Authors: Heryana Esya , Mahfudz Muhsin , Luthfiah Winona , Fitriani Fitriani , Raihan Raihan
Published: September 2022

This study aims to discuss the concept of dhikr in the Qur'an as mental health therapy for bipolar sufferers by explaining verses related to the concept of dhikr in the Qur'an as a therapy for bipolar disorder. This study uses a descriptive qualitative approach using the thematic interpretation or maudhu'i research method, this method seeks to collect verses from the Qur'an regarding the problems or topics to be discussed and then analyzed so that they will become a unified whole. The results and discussion of this study show the concepts offered by the Qur'an related to dhikr that can be used as a therapy for bipolar disorder which results in an imbalance of mind and soul which states the impact of dhikr to create peace and tranquility of the soul. This study concludes that there is an effect of dhikr that affects the mind and also the heart as mental health therapy for bipolar sufferers, namely with dhikr a person will feel peace and peace in his soul which makes the mind balanced, clear and more focused so that different feelings change automatically. drastic for people with bipolar can be controlled. Peace by remembering Allah swt. will seep into the heart and mind then dhikr not only has an impact on the mind which gives rise to clear thinking but more than that, dhikr also has an impact on the heart which creates peace of mind. This study recommends academics and research circles to develop further related to this research and be able to directly implement the concept of dhikr offered in the Qur'an as mental health therapy for bipolar sufferers.
Tobat sebagai Landasan Problem Solving: Studi Tafsir Tematik
Authors: M. Encep Iim A'nnunaim
Published: September 2022

The main advice of Islam is for sinners to repent immediately because religious arguments explain that repentance is a door of convenience, as well as acting as a procession for eliminating sins. Meanwhile, the problems faced by humans today are increasingly diverse and increasing. This study aimed to discuss repentance as a basis for problem solving. The method used in this study is a qualitative method based on the literature review with the content analysis. Then to explain the verse in this study, it was carried out using the thematic interpretation method (maudhu’i). The result of this study as a discussion that includes the meaning of repentance and the problem solving, verses about repentance related to the problem solving, and the analysis of repentance as a basis for the problem solving. This study concludes that based on the analysis carried out with thematic interpretation steps, it is known that denial and sin cause calamities and problems both on a small and large-scale. Then repentance exists as a purification step for the soul that is offered to eliminate drop calamities and problems and replace them with luck.
BENEFÍCIOS DA REALIDADE VIRTUAL E ROBÓTICA NA REABILITAÇÃO DE PACIENTES COM ESCLEROSE MÚLTIPLA- REVISÃO SISTEMÁTICA
Authors: Santos Fernanda Fernandes , Santos Dayana Da Silva
Published: September 2022

Introdução: A Esclerose Múltipla caracteriza-se como uma doença desmielinizante e autoimune, causada por inflamação no Sistema Nervoso Central, levando cada indivíduo a diferentes impactos, de modo que a neuroreabilitação, relacionada à tecnologia, pode ser indicada com o objetivo de facilitar o aprendizado motor através da interação homem-máquina.Objetivo:Avaliaros benefícios da Realidade Virtual e da Robótica, no tratamento fisioterapêutico de pacientes com Esclerose Múltipla. Métodos:Trata-se de uma revisão sistemática, utilizando a lista de verificação PRISMA, com pesquisa realizada entre outubro de 2020 e fevereiro de 2021. Incluídos: artigos publicados nos últimos 10 anos, em português/inglês, sobre o tema abordado e com pontuação de 6 a 10 na Escala Pedro. Excluídos: relatórios/estudos de caso, duplicatas e onde o título divergiu do tema abordado. Validando a estratégia de pesquisa, utilizou-se a ferramenta PRESS. Na extração de dados, utilizou-se a lista de verificação CASP e, no agrupamento dos dados, utilizou-se a diretriz SWiM. Excluídos: relatórios/estudos de caso, duplicatas e onde o título divergiu do tema abordado. Resultados: 705 artigos compuseram a amostragem inicial e após a aplicação dos critérios de avaliação, a amostra final totalizou 10 artigos, os quais foram avaliados quanto à qualidade metodológica, tipo de estudo, intervenção, resultados e conclusão obtidos. Conclusão: Embora existam variações no tratamento, a Realidade Virtual e a Robótica tornaram-se importantes aliadas no tratamento fisiológico de pacientes com Esclerose Múltipla. Destacamos a importância da criação de estudos, enfatizando pacientes com escala expandida do estado de incapacidade alta, para proporcionar maior confiabilidade quanto à aplicabilidade da técnica por meio da fisioterapia neurofuncional.
Comprometimentos motores e a Evolução da Doença de Parkinson
Authors: De Oliveira Cruz Ana Paula , Ribeiro Rachel Trinchão Schneiberg Kalid , Santos Dayana Da Silva
Published: September 2022

Introdução: A Doença de Parkinson (DP) caracteriza- se como uma doença neurodegenerativa, progressiva e multissitêmica causada pela morte dos neurônios dopaminérgicos da parte compacta da substância negra, que pode levar seus indivíduos a manifestar diversos sintomas motores durante a evolução da doença. Objetivo: Identificar, segundo a literatura, os comprometimentos motores da DP e associar com a evolução da doença. Materiais e Métodos: Trata-se de uma Revisão Sistemática, realizada no período entre dezembro de 2020 e maio de 2021, nas bases de dados PubMed, ScieLo, PEDro e LILACs. Foram incluídos estudos do tipo ensaio clínico randomizado, nos idiomas inglês e português, sem restrição de ano, realizados em humanos, que abordassem os comprometimentos motores em indivíduos diagnosticados com DP. Resultados: Foram identificados um total de 550 artigos, dos quais 545 foram eliminados, resultando no final a inclusão de 5 estudos publicados entre 2009 a 2014. Conclusão: Foram encontrados os comprometimentos motores mais clássicos da DP, contudo durante seu avanço é possível detectar outros sintomas motores que podem ter uma relevância diante o estadiamento da doença.
Biochemical and molecular adaptation of rice plants towards low phosphate condition
Authors: Huong To Thi Mai , Ha Chu Hoang , Mai Nga Thi Phuong
Published: September 2022

Rice is the staple food for half of the world's population. Phosphorus is an essential element for rice plant growth, development and production; however, the availability of soluble phosphate for plant uptake is often limited due to the binding with cation in different pH environments. Therefore, the development of rice plant varieties, which can grow well under a limited phosphate environment, is an urgent need for agricultural development for biotechnology. This study reported two contrasting rice varieties' biochemical and molecular adaptation toward a low phosphate medium. The results show that the response of these two varieties is genotype-dependent. We observed a higher phosphate use efficiency in the low-Pi-sensitive G299 rice variety than in the low-Pi-tolerant G22 rice variety.
Moreover, the expression of five out of six investigated genes relating to the low Pi responsive pathway, including two purple acid phosphatase (PAP), phosphate starvation response 2 (PHR2), SPX (SYG1/PHO81/XPR1) domain-containing gene, phosphate transcription factor 1 (PTF1) and phosphate 1 (PHO1) were significantly higher in the low-Pi-sensitive accession than in the tolerant genotype. Impressively, 214 times more expression of the PHO1 was observed in the leaves of the G299 variety than in the G22 variety, followed by SPX, PTF1, PHR2, and PAP21 genes. Similarly, the PHO1 was induced at the highest level in the roots of the G299 variety, followed by PAP21, PHR2, PTF1, and SPX1 genes. These findings supply further information for elucidation of the mechanism behind the response of rice plants to low phosphate medium and the development of the low Pi nutrient happy rice varieties.
Endophytic actinomycetes from mangrove plant \(\textit{Avicennia marina}\) in Quang Ninh province, Vietnam: distribution, cytotoxicity, and antioxidant activities
Authors: Quach Ngoc Tung , Bui Thi Lien , Vu Thi Hanh Nguyen , Nguyen Thi Thu An , Chu Hoang Ha , Phi Quyet Tien
Published: September 2022

Mangrove endophytes have recently gained considerable attention due to their diversity and abundance of novel bioactive secondary metabolites. Despite the fact that Streptomyces species are producers of more than 75% of commercialized antibiotics, Streptomyces associated with the extremely widespread mangrove plant Avicennia marina remain poorly characterized. In this study, nine actinomycetes were isolated from A. marina growing in a mangrove forest, as yet unexplored, of Quang Ninh province, Vietnam. Phylogenetic analysis of actinomycetes-specific 16S rRNA sequences indicated that they were subjected to five Streptomyces species including Streptomyces cacaoi, Streptomyces californicus, Streptomyces enissocaesillis, Streptomyces coelicoflavus, and Streptomyces variabilis, which have not been previously reported in mangrove plants. Among them, S. cacaoi AM1 showed strong inhibition effects against six tested pathogenic bacteria with inhibitory zones ranging from 7.5−22.3 mm. Using standard 3-(4,5-dimethythiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay, 100 µg/mL ethyl acetate extract of AM1 showed potent cytotoxicity against breast cancer MCF-7 and lung cancer A549 cell lines with cell viability of 16.5 ± 1.28% and 17.69 ± 2.3%, respectively. As for antioxidant activities, AM1 extract exhibited strong antioxidant activities against 1,1-diphenyl-2-picrylhydrazyl (DPPH) free radical (92.4 ± 0.004%) and superoxide anion radical (42.4 ± 0.019%), which were positively correlated to high polyphenol (84.3 ± 3.4 µg GAE/g FW) and flavonoid (34.9 ± 4.8 µg QE/g FW) contents. These findings indicated that S. cacaoi AM1 could be a promising reservoir of antibacterial, anticancer, and antioxidant agents. This is the first report of mangrove endophytic Streptomyces derived from A. marina.
Rice grain yield and quality improvement via CRISPR/Cas9 system: an updated review
Authors: ZEB Aqib , AHMAD Shakeel , TABBASUM Javaria , SHENG Zhonghua , HU Peisong
Published: September 2022

Rice (Oryza sativa L.) is an important staple food crop worldwide. To meet the growing nutritional requirements of the increasing population in the face of climate change, qualitative and quantitative traits of rice need to be improved. During recent years, genome editing has played a great role in the development of superior varieties of grain crops. Genome editing and speed breeding have improved the accuracy and pace of rice breeding. New breeding technologies including genome editing have been established in rice, expanding the potential for crop improvement. Over a decade, site-directed mutagenesis tools like Zinc Finger Nucleases (ZFN), Transcriptional activator-like Effector Nucleases (TALENs), and Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/CRISPR-associated protein 9 (Cas9) System were used and have played a great role in rice yield and quality enhancement. In addition, most recently other genome editing techniques like prime editing and base editors have also been used for efficient genome editing in rice. Since rice is an excellent model system for functional studies due to its small genome and close synthetic relationships with other cereal crops, new genome-editing technologies continue to be developed for use in rice. Genomic alteration employing genome editing technologies (GETs) like CRISPR/Cas9 for reverse genetics has opened new avenues in agricultural sciences such as rice yield and grain quality improvement. Currently, CRISPR/Cas9 technology is widely used by researchers for genome editing to achieve the desired biological objectives, because of its simple targeting, easy-to-design, cost-effective, and versatile tool for precise and efficient plant genome editing. Over the past few years many genes related to rice grain quality and yield enhancement have been successfully edited via CRISPR/Cas9 technology method to cater to the growing demand for food worldwide. The effectiveness of these methods is being verified by the researchers and crop scientists worldwide. In this review we focus on genome-editing tools for rice improvement to address the progress made and provide examples of genome editing in rice. We also discuss safety concerns and methods for obtaining transgene-free crops.
Antioxidant properties and cytotoxic effects of Alternanthera sissoo and Alternanthera bettzickiana extracts against cancer cells
Authors: SAENGHA Worachot , KARIRAT Thipphiya , BURANRAT Benjaporn , KATISART Teeraporn , MA Nyuk Ling , LUANG-IN Vijitra
Published: September 2022

This work aimed to evaluate the antioxidant capacities and cytotoxic attributes of Alternanthera sissoo (AS) and Alternanthera bettzickiana Green (AB) which are commonly grown in Thailand, yet not extensively-studied. Dried leaves were extracted by maceration using ethanol for 48 h and ethanolic extract solution was used. Cytotoxic, anti-proliferative, anti-migratory capacities and apoptosis-related gene expressions of AS and AB extracts on MCF-7, HepG2, and HeLa cell lines were investigated using 3-(4,5-dimethylthiazolyl-2)-2, 5-diphenyltetra zolium bromide (MTT) assay, anti-colony formation and wound healing test, respectively. The antioxidant activities by DPPH assay and FRAP assay of AS (130.62±1.61 µg TE/g extract and 24.76 ± 0.54 mg Fe(II)/g extract, respectively) were significantly higher than those of AB (104.34±3.68 µg TE/g extract and 23.13± 0.90 mg Fe(II)/g extract, respectively). Likewise, total phenolic content and the total flavonoid content of AS (7.43±0.39 mg GAE/g and 184.22±3.20 mg RE/g extract, respectively) were significantly higher than AB (6.10±0.29 mg GAE/g extract and 168.07±7.90 mg RE/g extract, respectively). HPLC analysis showed the predominance of myricetin, rutin and ferulic acid. For MCF-7, HepG2 and HeLa, the lowest IC50 values of 48.53 µg/mL, 69.94 µg/mL and 43.98 µg/mL, respectively were found in AS extract at 72 h exposure using MTT assay. Apoptotic bodies, gene expression and protein expressions related to apoptosis were more pronounced in AS treatment. Both AS and AB can be served as local foods with chemopreventive effects against breast, liver and cervical cancers. This work provided a foundation for future pharmacological research on Alternanthera plant extracts.
Garlic (Allium spp.) viruses: detection, distribution and remediation attempts in a European garlic collection
Authors: MANG Stefania M. , ALTIERI Luciana , CANDIDO Vincenzo , MICCOLIS Vito , CAMELE Ippolito
Published: September 2022

Garlic is an important vegetable crop in numerous countries used as food and natural based medicine. Similar to the majority of vegetatively propagated plants, garlic may be affected by several viruses that can cause severe crop losses. The present study aimed to screen 105 garlic accessions (mother plants) from 5 European countries (Germany, Czech Republic, Poland, Italy, and France) for possible presence of Onion yellow dwarf virus (OYDV), Leek yellow stripe virus (LYSV), Garlic common latent virus (GCLV) and Shallot latent virus (SLV). The occurrence of three Allexiviruses (GarV-A, GarV-B and GarV-C) in mixed assays was also investigated. Meristem-tip culture assays were performed in order to attempt eradication of the studied viruses. Garlic viruses identification was made by ELISA and RT-PCR. ELISA outcomes showed that all 105 garlic accessions were infected by different virus combinations. The OYDV and LYSV were identified, by ELISA, in all countries at 96% and 88,6% respectively and by RT-PCR at 99% and 96%. Furthermore, GCLV and SLV were detected by ELISA in about 88% and by RT-PCR at 89% and 90%, respectively with the exception of the studied Allexiviruses which were not amplified by RT-PCR with ALLEX1/ALLEX2 primers. Smaller meristem size (0,3-1,5 mm) led to better virus elimination efficiency (29%) compared to 8% obtained for the larger size (2-2,5 mm). The outcomes were opposite (16% vs. 90%) for plants regeneration. Virus elimination efficiency was linked to the virus type, e.g., OYDV and LYSV were eradicated at 90% while GCLV and Allexiviruses were difficult to eliminate (57,4% and 55,6% of eradication). Given the economic relevance of garlic crops worldwide and the frequently reported incidence of viral infections, it is important to make virus-free germplasm available. Therefore, investigating the garlic germplasm sanitary status and constantly improving it is of crucial importance aiming to increase the overall garlic production.
Comparative anatomy and pollen morphology of two endemic Noccaea species (Brassicaceae) and their taxonomic significance
Authors: ATASAGUN Bayram
Published: September 2022

This study was conducted for extensive and systemic investigation of anatomical, palynological and seed morphological properties of two endemic Noccaea species, naturally growing in Turkey. Independent sample T-test and box plot were carried out using quantitative characters of the studied species. The anatomical results showed that the species had similar characteristics, though there were significant differences in root cortex cells and trachea; stem epidermis, cortex cell and endodermis; leaf upper and lower epidermis, lower cuticle, mesophyll and palisade parenchyma.  Pollen grains of two endemic species were observed as radially symmetric, isopolar, with tricolpate aperture, prolate pollen shape and had small size. Pollen surface ornamentation was micro-reticulate in both species. Considering palynological characters, equatorial axis, AMB exine and intine have taxonomic importance. Seeds of N. birolmutlui were ovate to orbicular in shape and orange-brown in color, with colliculate ornamentation; however, the seeds of N. camlikensis were ovate to oblong in shape and brown and shiny in color, with colliculate-reticulate ornamentation.
Netflix's communication strategy on Twitter and Instagram during the unlock in Spain: humour, proximity and information
Authors: Gómez Erika Fernández , Martin-Quevedo Juan , Feijoo Fernández Beatriz
Published: September 2022

The Covid-19 pandemic and the arrival of Disney + marked the second quarter of 2020 in the Spanish audiovisual market. Thus, the period of home confinement among the Spanish population coincided with the irruption of the new streaming service of one of the best-known and most loved brands worldwide. However, Netflix was the most consumed SVoD during this period.

The objective of this research is to find out what the Californian company has done in communicative terms as a market leader and in the face of the need to adapt to the new circumstances of its audiences. The results show how Netflix Spain has integrated COVID-19 in its social media strategy in the pass between the lockdown and maximum consumption to a progressive lessening of social restrictions. The content analysis of Twitter and Instagram found 121 messages regarding pandemic (from a total of 1380). Netflix employed Twitter to connect with its audiences with humor, proximity and information, using taboos in the hardest moments, and an increased frequency of publications as the health situation improved. On the contrary, on Instagram there was no specific strategy, but imitation of the practices on Twitter and scarce references to COVID. Besides, there has been an evolution of the messages more or less parallel to the public health changes, choosing a strategy of proximity with the users, and with a communication closer to an influencer rather than a company.
Predictive factors of mortality in patients with pelvic fracture and shock submitted to extraperitoneal pelvic packing
Authors: FONSECA VINICIUS CORDEIRO , MENEGOZZO CARLOS AUGUSTO METIDIERI , CARDOSO JULIANA MYNSSEN DA FONSECA , BERNINI CELSO OLIVEIRA , UTIYAMA EDIVALDO MASSAZO , POGGETTI RENATO SÉRGIO
Published: September 2022

ABSTRACT Introduction: in recent decades, the extraperitoneal pelvic packing technique has been disseminated, but there are still few studies. Thus, it was decided to analyze the results of extraperitoneal pelvic tamponade, in patients with pelvic fracture and shock, in order to identify predictive factors for mortality. Methods: a retrospective review of medical records of patients submitted to extraperitoneal pelvic packing was conduced. We analyzed their characteristics, prehospital and emergency room data, pelvic fracture classification, associated and severity injuries, laboratory and imaging exams, data on packing, arteriography, and other procedures performed, complications, hemodynamic parameters, and amount of transfused blood products before and after packing. Results: data were analyzed from 51 patients, who showed signs of shock from prehospital care, presence of acidosis, with high base deficit and arterial lactate levels. Most patients underwent multiple surgical procedures due to severe associated injuries. The incidence of coagulopathy was 70.58%, and overall mortality was 56.86%. The group of non-surviving patients presented significantly higher age, prehospital endotracheal intubation, and lower Glasgow Coma Scale scores (p<0.05). The same group presented, before and after extraperitoneal pelvic packing, significantly worse hemodynamic parameters of mean arterial pressure, pH, base deficit, hemoglobin, and arterial lactate (p<0.05). The non-surviving group received significantly more units of packed red blood cells, fresh frozen plasma and platelets within 24 hours following extraperitoneal pelvic packing (p<0.05). Conclusion: age and base deficit are independent predictors of mortality in patients submitted to extraperitoneal pelvic packing.
O impacto da pandemia de COVID-19 na cirurgia de hernioplastia inguinal unilateral no Brasil
Authors: GARCIA GIOVANA SALVIANO BRAGA , FERREIRA KARINE COELHO DA SILVA , WANDERLEY LIGIA SOUZA , PINHEIRO JULIA MARIA MENDONÇA MACHADO , KORSACK ISADORA MACIEL , FRIGOTTO KATIA GLEICIELLY
Published: September 2022

RESUMO Objetivo: analisar os dados dos pacientes internados para realização de hernioplastia inguinal unilateral no Brasil no ano anterior à pandemia de COVID-19, e durante o período da pandemia no país. Métodos: trata-se de um estudo descritivo, utilizando dados referentes às internações para realização do procedimento cirúrgico de hernioplastia inguinal unilateral no Brasil no período de março de 2019 a fevereiro de 2020, comparando com os dados de março de 2020 até fevereiro de 2021. Os dados foram coletados do Sistema de Informações Hospitalares (SIH/SUS) e as variáveis selecionadas foram: número de internações, taxa média de permanência hospitalar e taxa de mortalidade. Resultados: ao todo, foram realizadas 119.312 internações para realização de hernioplastia inguinal unilateral no Brasil no período de março de 2019 a fevereiro de 2020. Já durante o período de pandemia no país, foram registradas 53.445 internações para este procedimento. A média de permanência hospitalar aumentou em relação ao ano anterior. A taxa de mortalidade registrada no ano anterior à pandemia foi de 0,11, já no período da pandemia, foi de 0,20. Conclusão: foi observado que durante o período de pico da pandemia de COVID-19 no Brasil, o número de internações para realização de hernioplastia inguinal unilateral foi reduzido em 55,21%. Contudo, houve um aumento significativo da taxa de mortalidade desse procedimento. Esse resultado pode ser explicado pelo aumento da mortalidade em pacientes infectados pelo vírus SARS-CoV-2, e também pela restrição da realização de procedimentos cirúrgicos eletivos nesse período, priorizando quadros emergenciais, os quais são mais complicados, e consequentemente, com maior mortalidade.
Segurança e eficácia do bypas gástrico em Y de Roux em pacientes idosos
Authors: QUINTERO JORGE HUMBERTO RODRIGUEZ , GROSSER RACHEL , VELEZ GUSTAVO ROMERO , RAMOS-SANTILLAN VICENTE OMAR , PEREIRA XAVIER , FLORES FERNANDO MUÑOZ , CHOI JENNY , MORAN-ATKIN ERIN , CAMACHO DIEGO , LIMA DIEGO LAURENTINO
Published: September 2022

RESUMO Introdução: o Bypass Gástrico Laparoscópico em Y de Roux (LRYGB) tem sido uma intervenção revolucionária para perda de peso com redução de até 60-70% do excesso de peso corporal. No entanto, esses resultados não são tão bem validados nos extremos de idade, onde a segurança da intervenção ainda possui algumas ressalvas. O objetivo deste estudo é avaliar a eficácia e segurança do LRYGB entre diferentes faixas etárias. Métodos: O banco de dados do Programa de Acreditação e Melhoria da Qualidade da Cirurgia Metabólica e Bariátrica (MBSAQIP) foi consultado para pacientes submetidos a LRYGB de janeiro de 2014 a dezembro de 2017 em uma única instituição. Quatro grupos foram criados e comparados dividindo a amostra por quartis de idade. O desfecho primário foi perda percentual de excesso de peso (%EWL) em 1 ano. Resultados: 1013 pacientes foram submetidos a LRYGB durante o período do estudo. A média de %EWL em um ano foi de 55%. Quando comparados entre os quartis, houve diferença significante no %EWL: 1º 62%, 2º 57%, 3º 54%, e 4º 47% (p=0,010). As diferenças nos desfechos secundários entre as faixas etárias não demonstraram significância estatística. Conclusões: embora os pacientes no quarto quartil de idade não tenham demonstrado um aumento estatisticamente significativo nos resultados adversos, eles perderam menos peso em comparação com outras coortes. O %EWL um ano após RYGB variou de acordo com a idade em nossa coorte. Os objetivos após a cirurgia bariátrica devem ser individualizados, pois a perda de peso é menos robusta com o envelhecimento.
Safety and efficacy of roux-en-y gastric bypass in older aged patients
Authors: QUINTERO JORGE HUMBERTO RODRIGUEZ , GROSSER RACHEL , VELEZ GUSTAVO ROMERO , RAMOS-SANTILLAN VICENTE OMAR , PEREIRA XAVIER , FLORES FERNANDO MUÑOZ , CHOI JENNY , MORAN-ATKIN ERIN , CAMACHO DIEGO , LIMA DIEGO LAURENTINO
Published: September 2022

ABSTRACT Introduction: laparoscopic Roux-en-Y Gastric Bypass (LRYGB) has been a revolutionary intervention for weight loss with reduction of up to 60-70% of excess body weight. However, these outcomes are not as well validated at the extremes of age, where the safety of the intervention still has some caveats. The aim of this study is to assess the efficacy and safety of primary LRYGB among different age groups. Methods: the Metabolic and Bariatric Surgery Accreditation and Quality Improvement Program (MBSAQIP) database was queried for patients who underwent primary LRYGB from January 2014 to December 2017 at a single institution. Four groups were created and compared by dividing our sample by age quartiles. The primary outcome was percent excess weight loss (%EWL) at 1 year. Additional operative outcomes and complications were also compared across groups. Results: a total of 1013 patients underwent non-revisional LRYGB during the study period. Mean %EWL at one year was 55%. When compared between quartiles, there was a statistically significant difference in %EWL: 1st 62%, 2nd 57%, 3rd 54% and 4th 47% (p=0.010). The differences in the secondary outcomes between age groups did not demonstrate statistical significance. Conclusions: though patients in the fourth age quartile (range) did not demonstrate a statistically significant increase in adverse outcomes, they did lose less weight compared to other cohorts. The %EWL at one year after RYGB varied by age in our cohort. Goals after bariatric surgery should be individualized as weight loss is less robust with aging.
A CARTOGRAFIA COMO FAZER-METODOLÓGICO DE PESQUISADORES ORGANIZACIONAIS: INVESTIGANDO FENÔMENOS CONTEMPORÂNEOS
Authors: Lima Eduardo Carneiro , Santos Ana Cristina Batista dos , Sampaio Patrícia Passos
Published: September 2022

RESUMO Este artigo tem como objetivo descrever um processo de pesquisa, em que utilizamos o método cartográfico para estudo de um tema fronteiriço no campo dos estudos organizacionais e do trabalho: o fenômeno slash. Propomos uma discussão metodológica sobre a cartografia, ampliando as possibilidades teóricas e empíricas, principalmente, para os estudos organizacionais. Descrevemos o processo cartográfico da nossa pesquisa em 03 (três) rotas: sobre a cartografia; sobre o cartógrafo; e cartografando. Como resultados, apresentamos 04 (quatro) sínteses, quais sejam: (i) o pesquisador-cartógrafo como parte da geografia de sua pesquisa; (ii) a convicção de que o trabalho do cartógrafo é construído aos poucos e em detalhes; (iii) as principais características observadas em campo sobre a cartografia nos estudos organizacionais; e (iv) contraponto a uma possível glamourização da dinâmica do fenômeno slash.
O PENSAMENTO DE NORBERT ELIAS: CONTRIBUIÇÕES PARA OS ESTUDOS ORGANIZACIONAIS
Authors: Ésther Ângelo Brigato
Published: September 2022

RESUMO Norbert Elias se inscreve numa perspectiva crítica à teoria sociológica predominante de seu tempo, notadamente o estrutural-funcionalismo. Ele recusa a compreensão de termos como “estrutura” e “função” num quadro de referência estático, que tende a assumir certo determinismo e pouca possibilidade de percepção da dinâmica social. Este artigo busca sintetizar, de forma integrada e articulada, suas principais concepções e formulações, de modo a trazer possíveis contribuições para o campo de estudos organizacionais. Neste aspecto, ressalta-se a combinação de diversas perspectivas sociológicas, conferindo-lhes uma abordagem única e peculiar, dentro da chamada sociologia dos processos ou da sociologia figuracional; em que recusa a dicotomia indivíduo/sociedade e a reificação de conceitos, articulando psicogênese e sociogênese como elementos indissociáveis para compreensão da vida social em longo prazo. Embora o autor não seja um teórico ou analista das organizações, sua teorização e seu método de análise possibilitam avanços para se compreender questões relevantes, como a dinâmica organizacional, identidade e relações de poder, bem como se pensar a organização como um figuração.
A VANTAGEM COMPETITIVA DAS EMPRESAS CLEANTECHS E O DESENVOLVIMENTO DE CAPACIDADES DINÂMICAS UTILIZANDO INTERNET DAS COISAS
Authors: Noronha Matheus Eurico Soares , Hayashi Victor Takashi , Silva Luiz Otávio Estevam da , Lima Matheus Nunes
Published: September 2022

RESUMO As empresas de tecnologia limpa (Cleantechs) utilizam diferentes tecnologias para o desenvolvimento de soluções e inovações no mercado. Entre essas tecnologias, o IoT (Internet of Things) se destaca por viabilizar a automação de processos e a criação de capacidades e soluções que diferenciam os modelos de negócios dessas empresas e podem gerar vantagens de mercado. A pergunta de pesquisa deste trabalho é: Como o IoT impulsiona o desenvolvimento de capacidades dinâmicas para obtenção de vantagem competitiva nas empresas Cleantechs? O objetivo é apresentar um modelo de desenvolvimento de capacidades dinâmicas por meio de IoT para obtenção de vantagem competitiva nas empresas Cleantechs. O percurso metodológico contou com a realização de uma pesquisa qualitativa de caráter descritivo. Foram realizadas 22 entrevistas, representadas por 17 empresas Cleantech. As lentes teóricas utilizadas foram: “IoT”, “Capacidades Dinâmicas” e “Vantagem Competitiva”. Os resultados indicam que o IoT pode minimizar os custos de transação no processo de adaptação de produtos e serviços, aumentar a previsibilidade de incertezas e riscos, além de fomentar a agilidade nas organizações. O trabalho apresenta como contribuição científica um modelo que demonstra como ocorre o desenvolvimento de capacidades dinâmicas via IoT para vantagem competitiva de mercado.
GESTIÓN DEL CONOCIMIENTO EN CLAVE DE DERECHOS HUMANOS: UN ANÀLISIS DE LOS PROGRAMAS DE DESARROLLO CON ENFOQUE TERRITORIAL (PDET) EN COLOMBIA
Authors: Rodriguez-Rincón Yolanda , Carvajal Lady Andrea Suarez
Published: September 2022

RESUMO El objetivo de este artículo es presentar un análisis documental de un conjunto de textos institucionales en Colombia sobre los Programas de Desarrollo con Enfoque Territorial (PDET) con énfasis en su Pilar 8, para considerar la forma en la cual se gestiona el conocimiento en derechos humanos. Los PDET surgen dentro del Acuerdo de Paz firmado en 2016 (entre el estado y la guerrilla de las Farc-ep), como dimensión de garantía de los derechos en los territorios especialmente afectados por el conflicto armado interno. Frente a concepciones tradicionales, el conocimiento se asume como experiencia situada, significada por entramados de subjetividades y territorialidades, cuya gestión implica producciones en tensión con discursos y tecnologías gubernamentales. Se trata de un estudio cualitativo, que sigue una mirada crítico-hermenéutica desde la cual se realiza un análisis del discurso sistematizado y organizado con apoyo del software AtlasTi. Se muestra que el contenido cognitivo que presenta la narrativa del Acuerdo, afirma la garantía y protección de los derechos humanos en los territorios-PDET; sin embargo, se infiere que, dada la débil implementación, se asiste a un giro tanto de la propia narrativa como de la gestión de conocimiento sobre el territorio.
PROFESSORES O TEMPO TODO: UM ESTUDO SOBRE AS CONDIÇÕES MATERIAIS, FÍSICAS E PSICOLÓGICAS DE DOCENTES NO ENSINO SUPERIOR DURANTE A PANDEMIA DO COVID-19
Authors: Calderari Egon Bianchini , Vianna Fernando Ressetti Pinheiro Marques , Meneghetti Francis Kanashiro
Published: September 2022

RESUMO A pandemia causada pelo COVID-19 provocou transformações na organização social do trabalho, ocasionada principalmente pela expansão do trabalho remoto, e afetou trabalhadoras e trabalhadores brasileiros, já prejudicados pelas sucessivas reformas trabalhistas e previdenciárias realizadas especialmente no decorrer das últimas três décadas. Com o trabalho docente não foi diferente. O presente artigo tem como objetivo analisar de que forma as condições materiais, físicas e emocionais do docente universitário, que atuava no modelo presencial no momento pré-pandemia, afetam esse sujeito no momento da pandemia. Para tanto, adotamos um delineamento qualitativo, que contou com a realização e a análise de conteúdo de 18 entrevistas com professores e professoras que ministraram aulas para cursos de graduação e especialização em Administração e Contabilidade durante o primeiro semestre de 2020. Os resultados indicam que as adaptações emergenciais realizadas na organização do trabalho e a inadequação dos recursos materiais disponíveis sobrecarregaram os professores com novas funções e atividades, com efeitos prejudiciais às suas condições físicas e psicológicas. A ausência de suporte institucional ao trabalho docente foi também um traço marcante identificado no período.