bluuebunny/crossref_metadata_2025 huggingface dataset:
Exploring a Factor for Domestic Violence Beliefs: A Demonstration of Measurement Ambiguity
Authors: Wareham Jennifer , Wagers Shelly M.
Published: September 2018

Significant effort and money has been spent to change social and legal responses to domestic violence (DV) but, current statistics indicate relatively little decline in incidence rates and the literature contains conflicting findings, resulting in several controversies and heated political debates. Most of the rhetoric surrounding the controversial findings focus on theories and contextual issues related to survey instruments. However, this article seeks to raise another important issue that is common in criminological literature: poor measurement development and practices. Specifically, inconsistencies in scale development, psychometrics, and reporting practices for measurement lead to poor scale development and analytical confusion. We argue that poorly developed measures used repeatedly and slightly altered across varying studies contribute to the controversies in the literature. This article serves as an example of scale development to stimulate conversation regarding measurement issues amongst social scientists by focusing on one example regarding the measurement of DV beliefs. Exploratory and confirmatory factor analyses are used to explore the dimensionality of beliefs to develop the best measure for the data. Results highlight the need for more rigorous statistical estimation models and empirically supported psychometric techniques, and the need for further replication when developing composite measures of latent constructs.
Budaya Islam Lokal di Kampung Al-Munawar Palembang
Authors: Mardeli Mardeli
Published: September 2018

Culture is a habit of an individual that must be shared by a group of people. A group has a group if its citizens have together with the same pattern of thinking and behave gained through the learning process. One can be defined as a set of beliefs of values and ways of behavior, habits learned together by citizens from a group living in a region And has a language that neighbors can not understand. In each society, by its members the development of ideal cultural patterns and these patterns are reinforced by cultural matters. The ideal cultural patterns contain the things that most of them need to be filled to do in certain circumstances. These patterns are often called norms. Hard as we all know not everyone in their culture has always been what it has been all about as an ideal. Because if the community always there and the community that exist in the community. Then there will be no so-called crime-the cultural cart. Some of the ideal patterns in life are different from the actual patterns because of patterns that have been ruled out by the ways in which society has been accustomed.
Analisis Kebutuhan Materi Ajar “Berbicara Bahasa Arab” Berbasis Pendekatan Komunikatif bagi Pembelajar Non-Bahasa Arab
Authors: Syarifuddin Achmad
Published: September 2018

Speaking is very synonymous with a person's ability to use the language in communication. Therefore, to have Arabic skill means that ability to use the Arabic language in speaking. Not just to say "Arab" that everyone can do it. But, however, speaking is often considered as a big problem, so it is not uncommon to target this ability is avoided because it is considered difficult. In addition, for Indonesian people, especially who do not or rarely interact with people who speak Arabic in their daily life, speaking Arabic is is bored thing and it does not become a necessity. In fact, every human being is given a gift by God in the form of the ability to speak. Even in terms of mantiq science, human is referred to as "al-hayawan al-natiq" (human being is a living being who speaks). This study analyzed the need to speak Arabic as a foreign language in the State Islamic College (PTKIN) includes needs category, learning method in Communicative approach. From the result of the research, it can be concluded that the non-linguistic department students in PTKIN (especially UIN Raden Fatah Palembang) are included in the category of beginner in learning Arabic, while the Arabic learning requirement category is included in the category of normative needs. However, with a communicative approach the Arabic learner can achieve speaking skills in the form of short conversations and introducing himself.
Zikir Ratib Haddad: Studi Penyebaran Tarekat Haddadiyah di Kota Palembang
Authors: Noupal Muhammad
Published: September 2018

Penelitian ini dilatarbelakangi adanya fenomena menarik terkait maraknya pembacaan zikir Ratib Haddad di kota Palembang. Sebagaimana diketahui, zikir Ratib Haddad merupakan zikir para penganut tarekat Haddadiyah yang kebanyakan justru dianut masyarakat keturunan Arab Hadramaut. Studi ini menggunakan pendekatan fenomenologis untuk melihat bagaimana zikir ini dibaca dan menjadi gambaran penyebaran tarekat Haddadiyah di Palembang. Hasil penelitian ini mengungkapkan bahwa maraknya pembacaan zikr Ratib Haddad di kota Palembang tidak dapat dilepaskan dari peran Syekh Ali Umar Thoyyib dan para muridnya yang tergabung dalam majelis zikir al-Awwabien. Tetapi maraknya pembacaan zikir ini tidak menunjukkan bahwa tarekat haddadiyah dianut masyarakat Palembang; sebab zikir Ratib Haddad lebih dianggap sebagai zikir umum yang pembacaannya boleh dilakukan oleh siapa saja.
LA FRONTIÈRE À L’ÉPREUVE DE L’HOSPITALITÉ
Authors: Thomasset Alain
Published: September 2018

RÉSUMÉ: Realite physique, la frontiere est aussi et d’abord symbolique. Elle est une realite de structure de l’humain. L’article met en evidence la double dimension a la fois interieure et exterieure de la frontiere et sur la dialectique historique qui l’anime entre notre perception de l’étranger et la nécessaire délimitation d’une communaute donnee. Ceae dialectique qui dirige egalement les relations entre l’enracinement dans un peuple et une identité particulière et d’autre part l’ouverture a la fraternite universelle a laquelle le Christ nous invite. L’hospitalite, vertu centrale de la tradition chretienne, est aussi une donnee essentielle de la reflexion philosophique contemporaine. Grace a elle la frontiere peut devenir un lieu de passage et de verite. C’est dans ce passage de frontiere (frontiere de l’etranger, frontiere du pauvre, frontiere des religions) que peut s’operer la revelation du Dieu vivant.ABSTRACT: Physical reality, the border is also and first symbolic. It is a structure of human reality. The article points to its double dimension - inwards and outwards - and to the inherent historical dialectics between our perception of the alien and the necessary boundaries of a given community. This dialectics also underlies the relationship between our people’s heritage and identity and the universal kinship that Christ invites us to embrace. Hospitality, a central Christian virtue, is an essential dimension of the contemporary philosophical reflection. Thank to this attitude, the border can become a crossing place, a place of truth. In this crossing of borders (with the foreigner, with the poor, with others religions), the living God can reveal himself.
DIGNITATIS HUMANAE, THE FUTURE OF RELIGIOUS FREEDOM AND THE GLOBAL COMMOM GOOD
Authors: Hogan Linda
Published: September 2018

ABSTRACT: Our global and local conversations about human dignity and flourishing are shaped by the irreducible plurality of human experience, including religious experience and our political cultures must have the capacity to facilitate intercultural and interreligious exchange. In this context it is more vital than ever that religious traditions, including Catholicism, are to the fore as we go about the business of building a politics focused on the global common good. From the perspective of Catholicism, the contribution of Dignitatis humanae has yet to be properly realised, not only in respect to respect for religious pluralism, but more especially in respect to ethical pluralism.RESUMO: Nossas conversações locais e globais sobre a dignidade humana e a prosperidade são determinadas pela irredutível pluralidade da experiência humana, inclusive a experiência religiosa e nossas culturas políticas devem ter a capacidade de facilitar os intercâmbios interculturais e interreligiosos. Neste contexto, é mais vital do que nunca que as tradições religiosas, inclusive o Catolicismo, estejam em primeiro plano, pois nosso interesse é a construção de políticas centradas no bem comum. Na perspectiva do Catolicismo, a contribuição de Dignitatis Humanae ainda não se realizou adequadamente, não só no que se refere ao pluralismo religioso, mas especialmente no diz respeito ao pluralismo ético.
FRANCISCO E AS MIGRAÇÕES. UM OLHAR A PARTIR DAS MENSAGENS PARA O DIA MUNDIAL DO MIGRANTE E DO REFUGIADO (2014 A 2018)
Authors: Sanchez Wagner Lopes
Published: September 2018

RESUMO: O artigo analisa as Mensagens do Papa Francisco para o Dia Mundial do Migrante e do Refugiado, de 2014 a 2018, e apresenta, a partir desses documentos, os principais aspectos de seu pensamento em relação às migrações. O pressuposto adotado é de que o Papa compreende os fluxos migratórios no contexto mais amplo do processo atual de globalização e que faz dos seus discursos uma oportunidade para denunciar as condições desumanas a que estão submetidos os migrantes e refugiados atuais. O artigo tem quatro partes: na primeira, examina a conjuntura global atual que provoca a condições necessárias para o desenvolvimento dos fluxos migratórios; na segunda, o texto examina a homília proferida pelo Papa na ilha de Lampedusa; na terceira, são analisadas as Mensagens objeto do artigo; por fim, na última parte, o texto apresenta os aspectos centrais do pensamento de Francisco sobre as migrações presentes nas Mensagens.ABSTRACT: This article analyzes Pope Francis’ Messages addressed to the World Day of Migrants and Refugees, from 2014 to 2018. Based on these documents, it presents the main aspects of the Pope’s thoughts on Migration. The assumption is that he understands migratory flows in the broader context of the current process of globalization, and that this makes his speeches an opportunity to denounce the inhuman conditions to which migrants and refugees are subjected today. The article has four parts: first, it examines the current global conjuncture that causes the necessary conditions for the development of migratory flows; secondly, the text examines the homily given by the Pope on the island of Lampedusa; third, the Messages on the topic are analyzed; finally, the text presents the central aspects of Francis’ thoughts on Migration that are present in those Messages.
Clinical prognosis and basics of anti-neoplastic therapy
Authors: MADEJ JANUSZ A.
Published: September 2018

The histopathological examination can be completed by immunohisto(cyto)chemical examination, cytometry or molecular techniques, what allows to determine the statistical probability of metastasis. It improves the patient’s qualification to appropriate individual treatment that can be most effective with fewer side effects. The basis of neoplastic treatment, including multidrug resistance (MDR) was described. I characterize the role of transporters (molecular pumps, e.g. ABC - ATP-binding cassettes, RND, SMR, MFS and P450 – CYP), complication of neoplastic therapy (e.g. myelosuppression, acute tumor lysis syndrome) and minimal residual disease (MRD).
Taksi Duraklarının Konum ve Kapasitelerinin, Erişilebilirlik Ölçütleri ve Nüfus Dağılımı Kapsamında Değerlendirilmesi: Tekirdağ-Çorlu Örneği
Authors: GÜLHAN Görkem , YİĞİT Halil İbrahim
Published: September 2018

Toplu taşımacılıkta tür seçimi coğrafya, ulaşım alışkanlıkları, ekonomik koşullar ve nüfus gibi pek çoketkene göre oluşmaktadır. Taksi taşımacılığı büyükşehirlere doğru gidildikçe ve nüfus yoğunluğu arttıkça kullanımıartan bir toplu taşıma türüdür. Özellikle durak yerlerinin düzensizliği ve erişilebilirliğinin zayıf olması, taksitürüne olan talebin azalmasına ve dengesiz dağılmasına neden olmaktadır. Bu çalışmada, Çorlu’da taksi durakları,durakların mevcut konumları, taksi sayıları, türlerine göre plaka sayıları, mahallelerin nüfusları, mahallelerin nüfusyoğunlukları, mahallelerin alansal büyüklükleri, mahallelerde kişi başına düşen taksi sayısı ve km2‘ye düşen taksisayıları tespit edilmiştir. Bölgedeki zonlar nüfus yoğunluklarına ve arazi kullanım dağılımlarına göre alt zonlaraayrılmıştır. Taksi duraklarının erişilebilirlik alanları 500 m yürüme mesafesi baz alınarak oluşturulan çemberlervasıtasıyla belirlenmiştir. Zonların nüfusları, nüfusun duyduğu taksi ihtiyacı, taksi duraklarına yaya erişimi vemevcut duraklardaki taksi sayıları karşılaştırılarak mahallelerde nüfusa oranla hizmet vermesi öngörülen taksisayıları belirlenerek mevcut zonların yeterliliği sorgulanmıştır. Elde edilen verilere göre, Çorlu’da 325 taksininmevcut nüfusun ihtiyaçlarını karşılayacağı bulunmuştur. Öneri dağılım ile birlikte taksi duraklarının hizmet alanı235 km²‘ye çıkmaktadır. Mevcut durumda çalışma alanının %23’üne hizmet sağlanırken, öneri dağılım ile beraberhizmet alanı %37’ye çıkmıştır.
The Concept of Resilience: A Critical Evaluation of Erzurum
Authors: DURSUN Doğan
Published: September 2018

This study aims to evaluate existing urbanization practices of Erzurum in terms of the conceptof resilience. In this context, consistency of existing urbanization dynamics and ecological system is questionedthrough resilience perspective in order to determine the future economic, social and ecological risks for Erzurum.Thus, to cover all these three areas, indicators such as the changes in employment rate, income and main economicactivities; changing population, education and migration status, dependency ratios and welfare; changing land usecharacteristics in historical process are used. The findings show that urbanization policy and practices, economicsituation and social structure in Erzurum are not resilient against the changes in the system and sometimes theyare the reasons of ecologic, economic and social vulnerabilities. A new planning approach should immediately bedeveloped with the resilience perspective. Otherwise, the city will be faced with immense risks in the near future,especially in terms of livability.
İmidakloprit ve Asetamiprit’in Gammarus kischineffensis (Amphipoda:Crustacea) Üzerine Akut Toksik Etkisinin Değerlendirilmesi
Authors: DEMİRCİ Özlem
Published: September 2018

Bu çalışmada, önemli bir organik ksenobiyotik sınıfı olan neonikotinoit pestisitlerden asetamiprit veimidakloprit’in Gammarus kischineffensis üzerine akut toksik etkisini araştırmak üzere, 48, 72 ve 96 saatlik LC50değerleri belirlenmeye çalışılmıştır. Kullanılan doz aralığında; asetamiprit için LC50 değeri 72 ve 96 saat içinsırasıyla 1.687 ve 0.517 µg L-1; imdakloprit için 48, 72 ve 96 saatteki LC50 değeri 9764.4, 4546.7 ve 1560.9 µg L-1olarak belirlenmiştir.
Meyan Kökü (Glycyrrhiza glabra) Ekstraktı ve Sıvıcam Karışımı ile Boyanan Bazı Odun Türlerinin Yanma Özellikleri
Authors: YENİOCAK Mehmet , GÖKTAŞ Osman , ÖZEN Ertan , ÇOLAK Mehmet , UĞURLU Mehmet
Published: September 2018

Bu çalışmanın amacı; Meyan kökü (Glycyrrhiza glabra) bitkisinden elde edilen ekstraktlar ve sıvıcamkarışımı ile ağaç malzemenin boyanması ve yangın geciktiricilik özelliklerinin belirlenmesidir. Bu kapsamda;deneylerde üç odun türü sarıçam (Pinus sylvestris L.), kestane (Castanea sativa Mill.) ve maun (Khaya ivorensis)kullanılmıştır. Meyan kökü ekstraksiyonu kaynatma metoduyla elde edilmiş, mordan maddeleri; alumiyumsülfat (KAl2(SO4)3.18H2O), demir sülfat (Fe2(SO4)3.7H2O) ve üzüm sirkesi ile sırasıyla 5%, 3% ve 10% oranındakarıştırılmış ve %20 oranında sıvıcam maddesi ilave edilmiştir. Elde edilen çözeltiler, ahşap örneklere daldırmametoduyla uygulanmıştır. Yanma testleri ASTM-E 69-02 (2002) standardına uygun olarak yapılmıştır. Deneylersonucunda yanmada ağırlık kaybı, CO, O2 ve sıcaklık ºC verileri elde edilmiştir. Sonuçlar incelendiğinde meyan köküekstraktı, mordan ve hatta sıvıcam katkısının yanmada ağırlık kaybı değerlerine herhangi bir etkisinin olmadığını,fakat sentetik boyaya yakın sonuçlar elde edildiği gözlenmiştir. Bu sebeple sentetik boyaların kullanılabildiğiyangın riskinin bulunmadığı yerlerde doğal boyaların kullanılabileceği sonucuna varılabilir.
Farklı Ekim Oranlarının Mısır-Soyanın Birlikte Üretiminin Bazı Agronomik ve Verim Özellikleri Üzerine Etkisi
Authors: AYDEMİR Serap Kizil
Published: September 2018

Bu çalışmanın amacı, Bilecik koşullarında yalın ve farklı ekim oranlarında kullanılan soyanın ve mısırınbitkisel özellikleri ile yem verimlerinin incelenmesi ve mısır bitkisinin ekim normunu azaltmadan soyanın katılımoranını belirleyerek otun verim ve kalitesini ve miktarını artırmaktır. 2015 yılında, tesadüf blokları denemedesenine göre üç tekrarlamalı olarak yürütülen denemede, mısır sıra arası 70, sıra üzeri 15 cm olacak şekildeekilmiş ve mısır sıra üzerine %30, %50 ve %70 oranlarında soya eklenerek, farklı ekim oranları kullanılarakmısır ve soya birlikte yetiştirilmiştir. Bu araştırma sonucunda; mısırda en yüksek bitki boy uzunluğu, yaprak vesap oranı, ham protein oranı, ham protein verimi ve toplam kuru madde verimi Mısır+%70 soya ekim oranındanelde edilmiştir. Ayrıca istatistikî olarak önemli çıkmamakla birlikte, en yüksek yeşil ot ve kuru madde verimi deMısır+%70 soya ekim oranından elde edilmiştir. Bununla birlikte, sindirim düzeyi çok yavaş ve düşük olduğundan,rasyonda düşük miktarlarda olması istenen ADF ve NDF oranları da Mısır+%70 soya ekim oranından en düşükoranda bulunmuştur. Araştırma sonunda, en yüksek toplam kuru madde verimi, toplam ham protein verimi, kurumadde verimi bakımından alan eş değerlik oranı ve ham protein verimi bakımından Mısır+%70 soya ekim oranıuygunluğuna karar verilmiştir.
Farklı Dozlarda Fosfor ve Humik Asit Uygulamalarının Glayöl Çeşitlerinde Mikro Besin Elementi (Fe, Cu, Zn ve Mn) İçeriklerine Etkisi
Authors: GÜLSER Füsun , TÜRKOĞLU Nalan , SÖNMEZ Ferit , ÇAVUŞOĞLU Mehmet Nuri
Published: September 2018

Bu araştırmada farklı dozlarda fosfor ve humik asit uygulamalarının glayöl çeşitlerinin besin elementi içeriği üzerine etkilerinin belirlenmesi amaçlanmıştır. Rose Supreme, Deppest Red ve Essential glayöl çeşitlerinin kullanıldığı denemede fosforun üç dozu (P1:0, P2:100, P3:200 mg kg-1) ve humik asidin üç dozu (HA1:0, HA2:1000, HA3:2000 mg kg-1) 3 kg yetiştirme ortamı içeren saksılara uygulanmıştır. Korm dikiminden 140 gün sonra deneme sonlandırılmıştır. Hasat edilen bitkilerde Fe, Cu, Zn ve Mn içerikleri analiz edilmiştir. Mikro besin elementi içeriği bakımından Cu hariç çeşitler arasında istatistiksel anlamda önemli farklılık bulunmamıştır. Cu içeriğinde farklı çeşitlerin meydana getirdiği değişim istatistiksel anlamda %5 düzeyinde önemli bulunmuştur. Farklı fosfor uygulamalarının bitkilerde Mn ve Cu içeriği üzerine etkilerinin istatistiksel anlamda %1 düzeyinde önemli olduğu belirlenmiştir. Bitkilerin Fe ve Cu içerikleri humik asit uygulamalarında istatistiksel olarak önemli (%1) düzeyde etkilenmişlerdir. Çinko ve Cu içeriklerinde çeşit x fosfor interaksiyonunun etkisi istatistiksel olarak %1 düzeyinde önemli bulunmuştur. Çeşit x Fosfor x Humik asit interaksiyonu ise Mn ve Cu içeriklerinde istatistiksel anlamda önemli (%1) değişimler meydana getirmiştir. En yüksek Fe ve Zn içerikleri HA’nın en yüksek dozunda sırasıyla 57.9 mg kg-1 ve 82.0 mg kg-1 olarak elde edilmiştir. En yüksek Cu içeriği ise HA’nın ikinci dozunda 11.4 mg kg-1 olarak bulunmuştur.
Performance and microbial community of the completely autotrophic nitrogen removal over nitrite process with a submerged aerated biological filter
Authors: Yue Xiu , Liu Zhuhan , Yu Guangping , Li Qianhua , Tang Jiali
Published: September 2018

Stable performance is a technical problem in the completely autotrophic nitrogen removal over nitrite (CANON) process with one single stage, which needs to be addressed. In the current work, a laboratory-scale submerged aerated biological filter (SABF) with a 3-L working volume was introduced into the CANON process to enhance its stable performance for 290 days under the following conditions: temperature of 30 ± 1 °C and dissolved oxygen (DO) level of 0.2–0.8 mg·L−1. The results showed that the average ammonium nitrogen removal efficiencies (ANRE) and total nitrogen removal efficiencies (TNRE) were 97.4% and 75.7%, respectively. A 16S rRNA gene high-throughput sequencing technology confirmed the phyla Proteobacteria and Planctomycetes as the ammonium oxidizing bacteria (AOB) and anaerobic ammonia-oxidizing bacteria (AnAOB) of this CANON process with SABF, respectively. The major contributor to nitrogen removal was the genus Candidatus Brocadia, in Brocadiae. The aim is to present an effective strategy as a reference for the design of full-scale plant for the CANON process.
Start-up performance of anaerobic/aerobic/anoxic-sequencing batch reactor (SBR) augmented with denitrifying polyphosphate-accumulating organism (DPAO) and their gene analysis
Authors: Zhang Yifang , Li Meng , Zhang Qian , Sang Wenjiao , Jiang Yiheng
Published: September 2018

This paper was aimed at investigating the bio-augmentation performance of anaerobic/aerobic/anoxic-type sequencing batch reactor (SBR) during its start-up period by introducing a strain of denitrifying polyphosphate-accumulating organism (DPAO). Two SBR reactors were inoculated to study the start-up performance, with one for DPAO introduction and the other as the control specimen. A comparison, of microbial community diversity based on the reactor which obtained a better performance, was made between polymerase chain reaction-denaturing gradient gel electrophoresis (PCR-DGGE) analyses encoded by 16S rRNA and functional genes (nirS, nirK). The results indicated that the introduction of DPAO had a positive effect on the biological system, including a reduction of the start-up period, the improvement of sludge characteristics and the removal efficiency of nutrients, especially for phosphorus. By comparing the phylogenetic relationship of 16S rRNA and functional genes (nirS, nirK) of the reactor augmented with DPAO, it could be found that the phylogenetic relationship of these genes were remarkably inconsistent with each other. Therefore, 16SrRNA should not be used to determine the microbial community diversity of functional bacteria which could accomplish denitrification, and gene nirK should not be neglected when determining functional bacteria.
Dynamics simulation of ammonia nitrogen absorption in a rural–urban canal on the Northeast China Plain
Authors: Song Yujia , Wang Xiaodong , Zhang Haiying
Published: September 2018

To study dynamic laws of ammonia nitrogen retention in a typical rural–urban fringe canal, NaBr was selected as a conservative tracer agent, and NH4Cl as an additive nutritive salt to conduct an instantaneously added tracer experiment outdoors. On this basis, tracer additions for spiralling curve characterisation (TASCC) method and nutritive spiral indexes were used for the quantitative depiction of retention dynamics of NH4+-N. The Michaelis–Menten (M-M) model was used to simulate absorption dynamic characteristics of NH4+-N. Results showed that the variation range of absorption length of NH4+-N under background concentration was 93.94–295.54 m with an average value of 177.41 m, the variation range of mass transfer coefficient was 0.16–0.38 mm/s with an average value of 0.26 mm/s, and the variation range of absorption rate was 0.16–0.38 mg/(m2⋅s) with an average value of 0.26 mg/(m2⋅s). The maximum absorption rate of NH4+-N obtained via M-M equation simulation was 0.59–1.38 mg/(m2⋅s), and the subsaturation constant was 1.10–5.03 mg/L. The variability of the dynamic absorption length, overall dynamic absorption rate, and overall dynamic mass transfer coefficient shown by NH4+-N within the range from background concentration to saturation concentration certified that TASCC could analyse the dynamic process of NH4+-N retention and absorption by the canal.
Página Legal del No. 16 de la Revista de El Colegio de San Luis, Nueva Época
Authors: De San Luis Revista de El Colegio
Published: September 2018

Se presentan en este documento los datos y nombres de las autoridades de El Colegio, así como el número y fecha de publicación de este ejemplar. Se incluye también información de los integrantes del Consejo Editorial.Se incluye además información del Director de la Revista y nombres de contacto de algunos de los colaboradores de la misma, algunos datos de impresión y el tiraje de los ejemplares impresos.
Transformación de la vivienda rural mexicana ante la migración. El caso de una localidad en Puebla, México
Authors: Juárez-Sánchez José Pedro , Ramírez-Valverde Benito , López-Fuentes Mayra , Ortega-López Gabriela
Published: September 2018

El objetivo de la investigación es realizar una tipología, así como definir las características arquitectónicas de la vivienda rural, en especial de la neovivienda rural de migrantes. Para ello, se revisó literatura sobre la vivienda rural y se llevó a cabo una investigación exploratorio-cualitativa basada en la observación de campo y en el análisis fotográfico. Entre los resultados, se encontraron cinco tipos de vivienda rural, dos de estos tipos presentan características arquitectónicas de los lugares donde los migrantes radicaron. Se encontró que las construcciones no satisfacen las necesidades de las familias que hospedan ni las del migrante a su regreso. Es por ello que algunas están abandonadas. El diseño arquitectónico de la vivienda moderna en un paisaje rural tiene efectos visuales que se evitarían con un diseño arquitectónico integral. Al final, se concluye que a la neovivienda se le debe incorporar las características de la vivienda rural con las simbólicas y de transculturalización para mejorar su diseño.
Imágenes de una memoria. Exégesis y representación del pasado entre los wixaritari (huicholes) de Nayarit y Jalisco de Paulina Faba
Authors: Fierro Hernández Olivia Graciela
Published: September 2018

Reseña del texto Imágenes de una memoria… manuscrito que demuestra cómo el estudio y análisis del arte rupestre permite comprender el tiempo y el espacio de los huicholes, la adquisición de conocimiento y su actuación en el mundo. Como prologa Marie-Areti Hers, el trabajo de Paulina Faba revela la importancia que los grabados rupestres mantienen hoy en día en la vida cotidiana y ritual de los huicholes.
O portfólio na formação em saúde: limites e possibilidades em uma experiência de educação a distância
Authors: Costa Maria Angélica , Dos Santos Nilton Bahlis , Navarro Vasconcellos Maria das Mercês , Lopes Renato Matos
Published: September 2018

The health formation portfolio: limits and possibilities in a distance education experience
PenseSUS e as redes sociais: a busca por estratégias de comunicação e os desafios para a democratização e descentralização do debate sobre o SUS
Authors: Cavalcante Clarisse Castro , Muzi Daniela , Krapp Juliana , Maria Marina
Published: September 2018

PenseSUS and social networks: the search for communication strategies and the challenges for the democratization and decentralization of the debate on SUS
Sulfur-containing Secondary Metabolites as Neuroprotective Agents
Authors: Venditti Alessandro , Bianco Armandodoriano
Published: September 2018

Sulfur-containing secondary metabolites are a relatively small group of substances of plant origin. The present review is focused on their neuroprotective properties. The results obtained in a series of in vitro and in vivo studies are reported. Among glucosinolates, the wide class of compounds in the sulfur-containing metabolites, glucoraphanin, sulforaphane and isothiocyanates proved to be the more studied in this context and showed interesting properties as modulators of several systems involved in the pathogenesis of neurologic diseases such as oxidative stress, inflammation and apoptosis. Allium sativum L. (garlic) is widely known for its sulfur-containing components endowed with health-promoting activities and its medicinal properties are known from ancient times. In recent studies, garlic components proved active in neuroprotection due to the direct and indirect antioxidant properties, modulation of apoptosis mediators and inhibiting the formation of amyloid protein. Dihydroasparagusic acid, the first dimercaptanic compound isolated from a natural source, effectively inhibited inflammatory and oxidative processes that are important factors for the etiopathogenesis of neurodegenerative diseases, not only for its antioxidant and radical scavenging properties but also because it may down-regulate the expression of several microglial-derived inflammatory mediators. Serofendic acid represents a rare case of sulfur-containing animal-derived secondary metabolite isolated from fetal calf serum extract. It proved effective in the suppression of ROS generation and in the expression of several inflammatory and apoptosis mediators and showed a cytotrophic property in astrocytes, promoting the stellation process. Lastly, the properties of hydrogen sulfide were also reported since in recent times it has been recognized as a signaling molecule and as a mediator in regulating neuron death or survival. It may be produced endogenously from cysteine but may also be released by sulfur-containing secondary metabolites, mainly from those present in garlic.
Translation of Basic Research into Clinics: Killer Immunoglobulin-like Receptors Genes in Autoimmune and Infectious Diseases
Authors: Aiello Anna , Candore Giuseppina , Accardi Giulia , Caruso Calogero , Colomba Claudia , Duro Giovanni , Gambino Caterina Maria , Ligotti Mattia Emanuela , Di Bona Danilo
Published: September 2018

Killer immunoglobulin-like receptors (KIRs) regulate the activation of natural killer cells through their
interaction with human leucocyte antigens (HLA). KIRs and HLA loci are highly polymorphic, and some of
their combinations have been found to protect against viral infections or to predispose to autoimmune disorders.
In particular, some activating KIRs profiles may be detrimental in autoimmune pathogenesis, and specific KIRs
may be particularly aggressive in the clearance of different microorganisms, protecting individuals in the control
of a given pathogen. So, considering that in the pathogenesis of many autoimmune disorders and infections innate
immunity plays a key role, the recent development for KIRs characterization, diseases monitoring, and treatment
becomes obvious. Here, we reviewed a growing body of evidence supporting the influence of KIRs variants and
their interaction with ligands in the development of the main human autoimmune and viral diseases, highlighting
the main applications in clinical practice.
Metabolomics in Vitamin Status Assessment
Authors: Varaeva Yurgita R. , Livantsova Elena N. , Ukrainets Igor V. , Kosyura Svetlana D. , Starodubova Antonina V.
Published: September 2018

The issue of vitamin deficiency persists to be a major health issue worldwide despite the advancements
in medicine. At the same time, the effect of marginal vitamin deficiency status on physiological processes is
proven. However, general methods such as immune-enzyme and fluorescence analysis, microbiological assays,
for example, have limitations in vitamin status assessment and are not able to reliably reflect personal vitamin
demand. The potential usefulness of modern metabolomics methods in vitamin status assessment is described in
this review. These methods can be used for vitamin metabolites detection as well as for comprehensive metabolic
phenotyping that makes them even more valuable.
Mapping Exchangeable Protons to Monitor Protein Alterations in the Brain of an Alzheimer’s Disease Mouse Model by Using MRI
Authors: Jahng Geon-Ho , Choi Wonmin , Chung Julius J. , Kim Sang T. , Rhee Hak Y.
Published: September 2018

Objective: The study aimed to investigate exchangeable proton signals of Aβ proteins of the
brains of Alzheimer’s disease (AD) model mice by using a chemical exchange-sensitive spin-lock
(CESL) MR imaging technique.

Method:

Eight non-transgenic (Tg) mice (5 young and 3 old) and twelve Tg-APPswe/PSdE9 mice (5
young and 7 old) were used in this study. CESL Z-spectra were obtained by using two saturation powers,
which were ω1 = 25 Hz with TSL = 3.0 s and ω1 = 500 Hz with TSL = 150 ms, at 71 offsets with uneven
intervals between the offset frequencies at Ω = ±7.0 ppm at a 9.4-T animal MRI system. For Zspectrum
analyses, regions of interest (ROIs) were drawn in the cortex, hippocampus, and thalamus of
both hemispheres. Magnetization transfer ratio asymmetry (MTRasym) curves were obtained from the Zspectra.
The Mann-Whitney test was used to compare the MTRasym values between the Tg and non-Tg
mice for each offset frequency and for each ROI.

Results:

The water saturation width of the full Z-spectrum was narrow with the 25-Hz saturation power,
but relatively broad with the 500-Hz saturation power. With the 25-Hz CESL saturation power, most of
the MTRasym values were negative for 3.5-, 3.0-, 2.0-, and 0.9-ppm offset frequencies and the MTRasym
values were significantly different between the control and Tg groups only in the left thalamus region at
3.5 ppm offset (p=0.0487). The MTRasym values were -6% to -7% for both 3.5 and 3.0 ppm, but less than
-2% for both 2.0 and 0.9 ppm. With 500-Hz CESL saturation power, all the MTRasym values were positive
for the 3.5-, 3.0-, 2.0-, and 0.9-ppm offset frequencies and the MTRasym values were not significantly
different between the control and Tg groups at all ROIs and at all offset frequencies. However, a
trend towards a significant difference was observed between the control and Tg groups in the right cortex
at 3.5 ppm (p=0.0578). The MTRasym values were 6% to 9% for 3.5, 3.0, and 2.0 ppm, but less than
2% for 0.9 ppm.

Conclusion:

In an in-vivo AD model experiment, MTRasym values increased with the high saturation
power than with the low saturation power. The MTRasym values were not significantly different, except
in the left thalamus region at 3.5 ppm offset. The CESL technique should be further developed to enable
its application in the brain of patients with neurodegenerative diseases.
Traumatic Brain Injury Altered Normal Brain Signaling Pathways: Implications for Novel Therapeutics Approaches
Authors: Rana Arti , Singh Shamsher , Sharma Ruchika , Kumar Anoop
Published: September 2018

Traumatic brain injury (TBI) is the main reason of lifelong disability and casualty worldwide. In the United State alone, 1.7 million traumatic events occur yearly, out of which 50,000 results in deaths. Injury to the brain could alter various biological signaling pathways such as excitotoxicity, ionic imbalance, oxidative stress, inflammation, and apoptosis which can result in various neurological disorders such as Psychosis, Depression, Alzheimer disease, Parkinson disease, etc. In literature, various reports have indicated the alteration of these pathways after traumatic brain injury but the exact mechanism is still unclear. Thus, in the first part of this article, we have tried to summarize TBI as a modulator of various neuronal signaling pathways. Currently, very few drugs are available in the market for the treatment of TBI and these drugs only provide the supportive care. Thus, in the second part of the article, based on TBI altered signaling pathways, we have tried to find out potential targets and promising therapeutic approaches in the treatment of TBI.
Astragaloside IV Supplementation Promotes A Neuroprotective Effect in Experimental Models of Neurological Disorders: A Systematic Review
Authors: Costa Ianara M. , Lima Francisca O.V. , Fernandes Luciana C.B. , Norrara Bianca , Neta Francisca I. , Alves Rodrigo D. , Cavalcanti José R.L.P. , Lucena Eudes E.S. , Cavalcante Jeferson S. , Rego Amalia C.M. , Filho Irami A. , Queiroz Dinalva B. , Freire Marco A.M. , Guzen Fausto P.
Published: September 2018

Background:

Neurological disorders constitute a growing worldwide concern due to the progressive aging of the population and the risky behavior they represent. Herbal medicines have scientific relevance in the treatment of these pathologies. One of these substances, Astragaloside IV (AS-IV), is the main active compound present in the root of Astragalus membranaceus (Fisch.) Bge, a Chinese medicinal herb with neuroprotective properties.

Objective:

In the present study we performed a systematic review that sought to comprehend the neuroprotective effect presented by AS-IV in experimental models of neurological disorders.

Methods:

This study is a systematic review, where an electronic search in United States National Library of Medicine (PubMed), Science Direct, Cochrane Library, Scientific Electronic Library Online (SciELO), Scopus, Web of Science, Medline via Proquest and Periodicos Capes databases covering the years between 2007 and 2017, using “Astragaloside IV” and “Neurodegenerative diseases”; “Astragaloside IV” and “ Neurological disorders” as reference terms was made.

Results:

A total of 16 articles were identified, in which the efficacy of AS-IV was described in experimental models of Parkinson’s disease, Alzheimer’s disease, cerebral ischemia and autoimmune encephalomyelitis, by improving motor deficits and/or neurochemical activity, especially antioxidant systems, reducing inflammation and oxidative stress.

Conclusion:

The findings of the present study indicate that the administration of AS-IV can improve behavioral and neurochemical deficits largely due to its antioxidant, antiapoptotic and antiinflammatory properties, emerging as an alternative therapeutic approach for the treatment of neurological disorders.
Exploring the Maximum Number of the Branch Pores in each Pore Tree Applied in an Optimized Tree-type Cylindrical-shaped Nanoporous Filtering Membrane
Authors: Zhang Yongbin
Published: September 2018

Background: An optimized tree-type cylindrical-shaped nanoporous filtering membrane
has been proposed. The performance of this membrane needs to be investigated.

Objective: The study aimed to investigate the maximum number of the branch pores in each pore tree
practically applied in this proposed membrane.

Methods: The analysis for the flow and transport of the filtered liquid in this membrane was derived
based on the nanoscale flow equation. The flow resistance of this membrane was defined and its
lowest value was found for the optimal condition.

Results: The dimensionless lowest flow resistance I f ,min of the membrane in the optimal condition
was calculated respectively for weak, medium-level and strong liquid-pore wall interactions, when
both the radius Rb,1 of the branch pore and the number N of the branch pores in each pore tree were
widely varied. It was shown that for any kind of liquid-pore wall interaction and any Rb,1 value,
when N is over 10, the value of I f ,min becomes slowly reduced with the increase of N; Even for
N=50, the value of I f ,min is only modestly reduced compared to that for N=10 for the same operating
condition.

Conclusion: It is suggested that the value of the maximum number Nmax of the branch pores in
each pore tree in this membrane should be taken as around 10 in spite of liquid-pore wall interactions,
from the viewpoint of engineering application.
New Er3+-substituted NiFe2O4 Nanoparticles and their Nano-heterostructures with Graphene for Visible Light-Driven Photo-catalysis and other Potential Applications
Authors: Anwar Asima , Yousuf Muhammad Asif , Tahir Bashir , Shahid Muhammad , Imran Muhammad , Khan Muhammad Azhar , Sher Muhammad , Warsi Muhammad Farooq
Published: September 2018

Background:

Spinel ferrites have great scientific and technological significance because of their easy
manufacturing, low cost and outstanding electrical and magnetic properties. Nickel ferrite nanoparticles are
ferromagnetic material with an inverse spinel structure. They show remarkable magnetic properties and hence
have a wide range of applications in magnetic storage devices, microwave devices, gas sensors, telecommunication,
drug delivery, catalysis and magnetic resonance imaging.

Objective:

The aim and objective of this research article is to study the relative effect of NiErxFe2-xO4 nanoparticles
and their composites with reduced graphene oxide (rGO) for the photocatalytic degradation reaction and
other physical parameters.

Method:

Rare earth Er3+ substituted NiErxFe2-xO4 nanoparticles were synthesized via the facile wet chemical
route. Six different compositions of NiErxFe2-xO4 with varied Er3+ contents such as (x) = 0.00, 0.005, 0.01, 0.015,
0.02 and 0.025 were selected for evaluation of the effect of Er3+ on various parameters of NiFe2O4 nanoparticles.
Reduced graphene oxide (rGO) was prepared by Hummer’s method and was characterized by UV-Visible spectroscopy,
X-ray powder diffraction and Raman spectroscopy. Nano-heterostructures of NiErxFe2-xO4 with rGO
were prepared by the ultra-sonication method.

Results:

X-ray powder diffraction (XRD) confirmed the spinel cubic structure of all the compositions of NiErx-
Fe2-xO4 nanoparticles. The photocatalytic degradation rate of methylene blue and congo red under visible light
irradiation was found faster in the presence of NiErxFe2-xO4-rGO nanocomposites as compared to bare nanoparticles.
It was also investigated that as the Er3+ contents were increased in NiErxFe2-xO4 nanoparticles, the dielectric
parameters were largely affected. The room temperature DC-resistivity measurements showed that the Er3+ contents
in NiFe2O4 are responsible for the increased electrical resistivity of ferrite particles. The electrochemical
impedance spectroscopic (EIS) analysis of NiErxFe2-xO4 nanoparticles and NiErxFe2-xO4-rGO nanocomposites
revealed that the ferrite particles possess low conductance as compared to the corresponding composites with
graphene.

Conclusion:

The data obtained from all these characterization techniques suggested the potential applications of
the NiErxFe2-xO4 nanoparticles and NiErxFe2-xO4-rGO nanocomposites for visible light driven photo-catalysis and
high-frequency devices fabrication.
CellSaic, A Cell Aggregate-Like Technology Using Recombinant Peptide Pieces for MSC Transplantation
Authors: Nakamura Kentaro
Published: September 2018

In the field of stem cell therapy, research on the application of mesenchymal stem cells
(MSCs) has flourished because of the various functions. On the other hand, research on the method of
cell transplantation has developed from the administration of cell suspensions to cell-sheet engineering
and 3D technology. In the trend, a cell transplantation platform named CellSaic, which is a combination
of xeno-free recombinant scaffolds in a cell aggregate-like shape, was developed. CellSaic is the cell
transplantation platform that can prevent the central necrosis within cell aggregates by arranging the
cells and petaloid pieces of recombinant peptide (RCP) in a mosaic. The prevention of central necrosis
is the most significant advantage over other 3D culture systems. This review details the unique characteristics
of CellSaic including safety examination results and describes its future application for MSC
transplantation. Particularly, in the application of MSCs, it has been reported that the MSC CellSaics
increased the effect on improving various symptoms compared with MSCs only in the application of
the therapy to inflammatory bowel disease (IBD), cerebral infarction, bone cartilage regeneration in
joints, and islet transplantation. In accordance with the “One Health” concept, it is anticipated that this
technology is expected to contribute to companion animal therapy and human therapy in the future.
A Review on The Role of VEGF in Tamoxifen Resistance
Authors: Mansouri Sepideh , Feizi Nikta , Mahdi Ali , Majidzadeh-A Keivan , Farahmand Leila
Published: September 2018

Background:

Certain molecular deviations can lead to the development of breast cancer. For instance,
estrogen and estrogen receptors play a significant role in inducing tumor proliferation. However, the efficacy of
endocrine therapy through the administration of anti-estrogen drugs, such as Tamoxifen, is challenged by acquired
resistance.

Methods:

Relevant articles were retrieved from Medline and google scholar. All were screened to select the ones
discussing the molecular mechanisms of angiogenesis and Tamoxifen resistance. The molecular interactions contributing
in the resistant network were studied from the eligible articles.

Results:

Tamoxifen resistance occurs as a consequence of over-activated signal transduction pathways such as RTK
s dependent cascades. It has been shown that microvessel count was greater in Tamoxifen resistant tissues than in
responsive ones.

Conclusion:

In this review, the interaction between estrogen, Tamoxifen, VEGF, and VEGF receptors (VEGFRs) in
Tamoxifen resistant cells has been discussed. VEGF and estrogen-independent growth cascades, especially MAPK
have a positive feedback loop in Tamoxifen resistant cells. It has been proposed that over-activated pathways in
Tamoxifen resistant cells induce pin1 mediated VEGF over-expression, which in turn result in enhanced activation of
MAPK.
Pain-Prescription Differences - An Analysis of 500,000 Discharge Summaries
Authors: Preissner Saskia , Siramshetty Vishal B. , Dunkel Mathias , Steinborn Paul , Luft Friedrich C. , Preissner Robert
Published: September 2018

Background:

Pain-relief prescriptions have led to an alarming increase in drug-related
abuse.

Objective:

In this study, we estimate the pain reliever prescription rates at a major German academic
hospital center and compare with the nationwide trends from Germany and prescription reports from
the USA.

Methods:

We analysed >500,000 discharge summaries from Charité, encompassing the years 2006
to 2015, and extracted the medications and diagnoses from each discharge summary. Prescription
reports from the USA and Germany were collected and compared with the trends at Charité to identify
the frequently prescribed pain relievers and their world-wide utilization trends. The average
costs of pain therapy were also calculated and compared between the three regions.

Results:

Metamizole (dipyrone), a non-opioid analgesic, was the most commonly prescribed pain
reliever at Charité (59%) and in Germany (23%) while oxycodone (29%), a semi-synthetic opioid,
was most commonly ordered in the USA. Surprisingly, metamizole was prescribed to nearly 20% of
all patients at Charité, a drug that has been banned for safety reasons (agranulocytosis) in most developed
countries including Canada, United Kingdom, and USA. A large number of prospective
cases with high risk for agranulocytosis and other side effects were found. The average cost of pain
therapy greatly varied between the USA (125.3 EUR) and Charité (17.2 EUR).

Conclusion:

The choice of pain relievers varies regionally and is often in disagreement with approved
indications and regulatory guidelines. A pronounced East-West gradient was observed with
metamizole use and the opposite with prescription opioids.
Differential miRNA Expression Profiles in Cumulus and Mural Granulosa Cells from Human Pre-ovulatory Follicles
Authors: Andrei Daniela , Nagy Roland A. , van Montfoort Aafke , Tietge Uwe , Terpstra Martijn , Kok Klaas , van den Berg Anke , Hoek Annemieke , Kluiver Joost , Donker Rogier
Published: September 2018

Background:

Mural Granulosa Cells (MGCs) and Cumulus Cells (CCs) are two specialized
cell types that differentiate from a common progenitor during folliculogenesis. Although these two
cell types have specialized functions and gene expression profiles, little is known about their microRNA
(miRNA) expression patterns.

Objective:

To describe the miRNA profile of mural and cumulus granulosa cells from human preovulatory
follicles.

Methods: Using small RNA sequencing, we defined the miRNA expression profiles of human primary
MGCs and CCs, isolated from healthy women undergoing ovum pick-up for in vitro Fertilization
(IVF).

Results:

Small RNA sequencing revealed the expression of several hundreds of miRNAs in MGCs
and CCs with 53 miRNAs being significantly differentially expressed between MGCs and CCs. We
validated the differential expression of miR-146a-5p, miR-149-5p, miR-509-3p and miR-182-5p by
RT-qPCR. Analysis of proven targets revealed 37 targets for miR-146a-5p, 43 for miR-182-5p, 2 for
miR-509-3p and 9 for miR-149-5p. Gene Ontology (GO) analysis for these 4 target gene sets revealed
enrichment of 12 GO terms for miR-146a-5p and 10 for miR-182-5p. The GO term ubiquitin-like protein
conjugation was enriched within both miRNA target gene sets.

We generated miRNA expression profiles for MGCs and CCs and identified several differentially
expressed miRNAs.