bluuebunny/crossref_metadata_2025 huggingface dataset:
Hipertensión arterial en adultos mexicanos: prevalencia, diagnóstico y tipo de tratamiento. Ensanut MC 2016
Authors: Campos-Nonato Ismael , Hernández-Barrera Lucía , Pedroza-Tobías Andrea , Medina Catalina , Barquera Simón
Published: May 2018

Objetivos. Describir la prevalencia de hipertensión arterial (HTA) en adultos, el porcentaje de ellos con diagnóstico previo y la proporción que tuvo un control adecuado. Ma­terial y métodos. Se midió la tensión arterial a 8 352 adultos que participaron en la Ensanut MC 2016. Se clasificó como hipertensos a quienes reportaron haber recibido previamente el diagnóstico de HTA, o presentaban cifras de tensión arterial sistólica (TAS) ≥140mmHg o tensión arterial diastólica (TAD) ≥90mmHg. Se consideró tensión arterial controlada cuando la TAS <140mmHg y la TAD <90mmHg. Resultados. La prevalencia de HTA en adultos fue de 25.5%, de los cuales, 40.0% desconocían tener HTA. De los hipertensos que tenían diagnóstico previo de HTA y que re­cibían tratamiento farmacológico (79.3%), 45.6% tuvo tensión arterial bajo control. Conclusiones. Un alto porcentaje de adultos desconocen tener HTA y de ellos casi la mitad tiene un control inadecuado. Debería evaluarse la pertinencia de los actuales programas de diagnóstico de HTA y la efectividad de sus estrategias de control.
Sobrepeso y obesidad en niños y adolescentes en México,actualización de la Encuesta Nacional de Salud y Nutrición de Medio Camino 2016
Authors: Shamah-Levy Teresa , Cuevas-Nasu Lucía , Gaona-Pineda Elsa Berenice , Gómez-Acosta Luz María , Morales-Rúan María. Del Carmen , Hernández-Ávila Mauricio , Rivera-Dommarco Juan Ángel
Published: May 2018

Objetivo. Actualizar las prevalencias de sobrepeso y obe­sidad (SP+O) y estudiar algunos determinantes asociados en población<20 años, de la Encuesta Nacional de Salud y Nutrición de Medio Camino 2016 (Ensanut MC 2016). Ma­terial y métodos. La Ensanut MC 2016 es una encuesta nacional probabilística. Se estimó el puntaje Z del índice de masa corporal. Se clasificó el riesgo de sobrepeso, sobrepe­so y obesidad de acuerdo con el patrón de referencia de la OMS. Se estudiaron variables sociodemográficas asociadas con sobrepeso mediante regresión logística. Resultados. La prevalencia nacional de SP+O en <5 años fue niñas 5.8%, niños 6.5%; escolares niñas 32.8%, niños 33.7%; adolescentes mujeres 39.2% y hombres 33.5%. Las mujeres adolescentes de localidades rurales mostraron un incremento de 2012 a 2016 de 9.5 puntos porcentuales. Conclusiones. La prevalencia de SP+O en niñas y mujeres en zonas rurales muestran un aumento importante en un periodo corto, lo que llama a implementar acciones de atención inmediatas.
Conocimiento y uso del etiquetado nutrimental de alimentos y bebidas industrializados en México
Authors: Tolentino-Mayo Lizbeth , Rincón-Gallardo Patiño Sofía , Bahena-Espina Liliana , Ríos Víctor , Barquera Simón
Published: May 2018

Objetivo. Documentar el conocimiento y uso de la información de las diferentes etiquetas colocadas en los productos industrializados en México. Material y méto­dos. En una submuestra de la Encuesta Nacional de Salud y Nutrición de Medio Camino 2016, se aplicó un cuestionario semiestructurado, desarrollado por investigadores libres de conflicto de interés, previamente validado y piloteado en población de diferentes estratos socioeconómicos, grupos de edad y regiones del país. Resultados. Se entrevistó a 8 667 adultos ≥20 años de edad. El etiquetado más utilizado para la elección de alimentos y bebidas industrializados fue la “tabla nutrimental” 41.5% (IC95% 36.9-46.3) y el de menor uso el “sello nutrimental” 4.3% (IC95% 3.1-5.7). Conclusiones. Es de suma importancia que las instancias reguladoras, en coordinación con la Secretaría de Salud, implementen un etiquetado frontal rápido de leer y de fácil comprensión con criterios nutrimentales que garanticen el cumplimiento de lo expuesto en los documentos oficiales, así como la estandarización del porcentaje de consumo de azúcar al recomendado por la OMS o a una menor cantidad dada la alerta epidemiológica por diabetes que experimenta el país.
Prevalencia de síntomas de sueño y riesgo de apnea obstructiva del sueño en México
Authors: Guerrero-Zúñiga Selene , Gaona-Pineda Elsa Berenice , Cuevas-Nasu Lucía , Torre-Bouscoulet Luis , Reyes-Zúñiga Margarita , Shamah-Levy Teresa , Perez-Padilla Rogelio
Published: May 2018

Objetivo. Estimar la prevalencia nacional de síntomas asociados con el sueño (SAS) en México, y su distribución por región, localidad y sexo. Material y métodos. Estu­dio transversal con muestreo probabilístico, representativo a nivel nacional en adultos mayores de 20 años. Se aplicó un cuestionario sobre duración de sueño, insomnio, uso de hipnóticos y riesgo de síndrome de apnea obstructiva del sueño (SAOS). Resultados. Los SAS más frecuentes fueron ronquido (48.5%) y dificultad para dormir (36.9%). Se identificó riesgo elevado de SAOS en 27.3% de los adultos, y se incrementa por índice de masa corporal (RM=1.1), edad (RM=1.03) y habitar zona urbana (RM=1.37). Se reportó insomnio en 18.8% de los participantes, que predomina en mujeres (RM=1.88). La duración promedio de sueño fue de 7.6 ± 3 horas; 28.4% de los adultos duermen <7 horas/ noche. Conclusiones. Existe una elevada prevalencia de SAS. Uno de cada cuatro adultos mexicanos tiene elevada probabilidad de padecer SAOS. La detección y tratamiento de SAS pudieran minimizar los efectos deletéreos en la salud.
What is Related to Towns’ Prospering and Decaying in Pennsylvania?
Authors: Ji Bianjie , Xia Zhiyue
Published: May 2018

This research aims to compare those degenerate towns and cities with booming ones to find out the strategies for rural and regional developments and help the decision-making through regional planning. Different from studies that only focus on decaying towns, this paper does not neglect those prosperous ones but compare the significant differences between them. The methods include 1) Principal Component Analysis (PCV) to create Development Index (DI) for every county subdivision from 2000 to 2015; and 2) spatial and temporal analysis to find whether some spatial patterns exist. Development Index (DI) is the core standard to evaluate some location’s development.
Utilization of Artificial Neural Network
Authors: Hafez Sherif Mohamed
Published: May 2018

Artificial neural networks (NN), have been applied to many construction management problems in urban projects. NN have showed some degree of success so the objective of this paper is to highlight some applications of this tool in the construction management field to help specialists find optimum solutions. A brief description of the input and output variables for each mentioned problem was illustrated in addition to the number and type of data set collected to train and test the neural network performance then the percentage error for each developed model was pointed out to demonstrate its accuracy.
Development of Urban Transportation System Based on Bus Rapid Transit
Authors: Putra Adris Ade , Makmur Muammar , Arsyad Muh
Published: May 2018

Urban transport systems in Indonesia have been influenced by kinds of traffic problems such as congestion, high accident rates and traffic violations and uncomfortable, safe, and orderly levels of public transport services. To develop urban transportation systems, a policy implementation is needed in public transportation such as special lanes for Bus Rapid Transit (BRT) as one of the alternative solutions to give better services for the public transport user. The purpose of this study is to count the demand of bus rapid transit, determine the number of corridors and halt for the BRT as well as know the types of BRT which should be operated in Kendari City in accordance with the needs of public transport users. The method used in this study is the quantitative method by collecting primary and secondary data which includes OD Matrix of a destination of the population travel, Number of Passengers up and down on each route, Load factor in each route, Travel time and Road Inventory Data. Other data include Road length, Road width, Road type, the width of trotoar, width of the median, and Road Pavement type. The results of this research are that the number of demand for public transportation in Kendari City are 28 buses with 8 units in the first corridor, 6 units in the second corridor, 8 units in the third corridor, and 6 units in the fourth corridor. Indeed, the total number of corridors needed to operate of BRT in Kendari requires 174 shelters. The potential population in Kendari City is categorized on the modest development and the existing conditions of the road, which is not too large for the BRT line planned. Therefore, the possibility of increasing the number of passengers then the type of bus which may be used as a fleet of BRT at the beginning of the operation is large floor buses total capacity of 79 people consisting of 49 seated passengers and 30 passengers standing.
Next Generation Antineoplastic Agents: A Review on Structurally Modified Vinblastine (VBL) Analogues
Authors: Haque Ashanul , Rahman Md. Ataur , Faizi Md. Serajul Haque , Khan Muhammad S.
Published: May 2018

Background:

Throughout the history of human civilizations, cancer has been a
major health problem. Despite the advancements made by modern medical sciences, complete
treatment or removal of cancerous cells is still a challenging task. Vinblastine, an alkaloid
obtained from Catharanthus roseus (L.) G. Don is one of the prominent antineoplastic
agents that is being clinically used. To improve the biological potential and reduce sideeffects
of this structurally complex molecule, several related analogues have been reported.
The present article reviews recently reported structurally modified vinblastine analogues and
its impact on biological activity.

Methods:

We carried out a comprehensive database search on recently reported vinblastine
analogues. Both upper (catharanthine) and lower (vindoline) structural units have been considered.
The role of functional group modification on anticancer activities has been discussed.
In addition, formulations based on vinblastine being considered by NIH, USA for
different types of cancers have also been discussed.

Results:

Around fifty papers were included in the review, including computational and experimental
ones. These papers were analysed to discuss the mechanism of action of the parent
vinblastine molecule and their analogues. The importance of each functionalities on its
anticancer activity have been discussed. This reviewed identified the potential sites of vinblastine
core where modification led to improved anticancer activity. Furthermore, several
new formulations have also been discussed which are under different phases of clinical trial.

Conclusion:

The present article highlights the importance of vinblastine in cancer chemotherapy.
Literature survey confirms that it is now possible to synthesize new molecules with
activity in picomolar range. Not only the periphery of the molecule, the core structure of this
magical molecule can be modified to achieve next generation antineoplastic agents.
Short-Term Response to Cholinesterase Inhibitors in Alzheimer’s Disease Delays Time to Nursing Home Placement
Authors: Wattmo Carina , Londos Elisabet , Minthon Lennart
Published: May 2018

Background:

A varying response to cholinesterase inhibitor (ChEI) treatment has been reported
among patients with Alzheimer’s disease (AD). Whether the individual-specific response directly
affects time to nursing home placement (NHP) was not investigated.

Objective:

We examined the relationship between the 6-month response to ChEI and institutionalization.

Methods:

In a prospective, observational, multicenter study, 881 outpatients with a clinical AD diagnosis
and a Mini-Mental State Examination score of 10-26 at the start of ChEI therapy (baseline) were included.
The participants were evaluated using cognitive, global, and activities of daily living (ADL)
scales at baseline and semiannually over 3 years. The date of NHP was recorded.

Results:

During the study, 213 patients (24%) were admitted to nursing homes. The mean ± standard
deviation time from baseline (AD diagnosis) to NHP was 20.8 ± 9.3 months. After 6 months of ChEI
treatment, the improved/unchanged individuals had longer time to NHP than those who worsened. The
prolonged time to NHP was 3 months for cognitive response (P=0.022), 4 months for global response
(P=0.004), 6 months for basic ADL response (P<0.001), and 8 months for response in all three scales
(P<0.001). No differences were detected between the improved and unchanged groups in any scales.

Conclusion:

Patients who exhibit a positive short-term response to ChEI can expect to stay in their own
home for 3-8 months longer. These findings underline the importance of a comprehensive clinical examination
including various assessment scales to evaluate treatment response and provide a more accurate
prognosis.
Progressive Supranuclear Palsy: Neuropsychopathological, Therapeutical and Bioethical Aspects
Authors: Vecchio Ignazio , Tornali Cristina , Malaguarnera Giulia , Bragazzi Nicola Luigi , Malaguarnera Michele
Published: May 2018

The progressive supranuclear palsy is a progressive neurodegenerative disease characterized
by Parkinsonism, oculomotor abnormalities, early postural instability and cognitive impairment. Neurodegeneration
in PSP is associated with tau protein, but the mechanisms by which tau abnormalities
lead to cell dysfunction and death are not well understood.

Neuro-behavioural problems related to the fear and loss of autonomy can determinate many bioethical
implications. Careful planning involving patients’ families, academic and industry researchers were necessary
to ensure improvement in quality of life.
Assessment of Total Phenolic Content and Antioxidant Activity of Ficus carica and Olea europaea L. Leaves Extracts
Authors: Benslama Abderrahim , Deghima Amirouche , Righi Nadjat
Published: May 2018

Background:

Ficus carica and Olea europaea are two medicinal plants which are widely distributed in Algeria, and used in food and traditional medicine.

Objective:

The objective of this work is the evaluation of the antioxidant capacity of different extracts of F. carica and O. europaea, for ends of flora valorization in Algeria.

Methods:

The dried leaves of the concerned plants Ficus carica and Olea europaea were submitted to sequential extraction with solvents of increasing polarity to give hexane, chloroform, ethyl acetate and methanolic extracts. The total phenolic and flavonoids were determined spectrophoto-metrically. The antioxidant activity of extracts was evaluated using 1,1’-Diphenyl-1-Picrylhydrazyl (DPPH) radicalscavenging and ferric reducing power test.

Results:

The results of the quantitative analysis show that the Methanolic Extract (ME) gives the highest yield with 16.43% and 19.98% for F. carica and O. europaea respectively. The analysis show that the highest amount of phenolic compounds was recorded in the ME of O. europaea (171.40±6.79 µg GAE/ mg E), when the the highest amount of flavonoids was recorded in the CHE of the F. carica (34.06± 0.05 µg QE/ mg E). In addition, the results show that the Ethyle Acetat Extract (EAE) exhibit the highest antiradical activity against DPPH free radical with an EC50=45.21±1.12 and 8.20±0.37 µg/ml for F. carica and O. europaea, respectively. Moreover, the EAE of the two plants present the highest reducing effect compared to other extracts at concentration of 200 µg/ml.

Conclusion:

The obtained results revealed the presence of a strong correlation between the antioxidant activity of the extract and its total phenolic content. Furthermore, they reported that the EAE have a considerable antioxidant capacity. This can be considered as an alternate natural source of antioxidants used generally as additives in food and pharmaceutical preparation.
Exploring the Free Radical Trapping Ability of Green Tea Extracts by Optimizing Extraction Conditions
Authors: Ashfaq Faiza , Butt Masood S. , Bilal Ahmad , Suleria Hafiz A.R.
Published: May 2018

Background:

The importance of polyphenols to curb lifestyle related disorders has also
raised the worth of green tea polycatechins. Besides, optimization of extraction conditions is gaining
wide acceptance to attain maximum polyphenols out of plant matrix.

Methods:

Considering the fact, in the present study, nine green tea solvent extracts were prepared by
optimizing solvents; aqueous ethanol, aqueous acetone and aqueous ethyl acetate in 1:1 ratio and extraction
time; 35, 50 & 65 min at constant temperature 50ºC to achieve an optimal quantity of green tea
polycatechins.

Results:

The results indicated significant impact of extraction solvents and time on phytochemistry and
free radical scavenging potential with maximum potential attained by acetone extracts of green tea at 50
min i.e. total polyphenols 1325.81±64.85 mg GAE/100g, flavonoids 139.78±5.42 mg/100g, DPPH (1,1-
diphenyl-2-picrylhydrazyl) inhibition 86.69±4.01%, β-carotene & linoleic acid assay 78.47±3.57%,
FRAP (Ferric Reducing Antioxidant Power) value 19.36±0.94 mM/L Fe+2, ABTS [2, 2'-azino-bis(3-
ethylbenzothiazoline-6-sulphonic acid)] value 11.10±0.49 μM Trolox Eq/g and metal chelating activity
16.93±0.81 mg EDTA/g.

Conclusion:

Conclusively, acetone as solvent and 50 min extraction time have proven optimized extraction
conditions for green tea polycatechins.
Cold Physical Plasma-Treated Buffered Saline Solution as Effective Agent Against Pancreatic Cancer Cells
Authors: Bekeschus Sander , Käding André , Schröder Tim , Wende Kristian , Hackbarth Christine , Liedtke Kim R. , van der Linde Julia , von  Woedtke Thomas , Heidecke Claus-Dieter , Partecke Lars-Ivo
Published: May 2018

Background:

Cold physical plasma has been suggested as a new anticancer tool recently. However,
direct use of plasma is limited to visible tumors and in some clinical situations, is not feasible. This includes
repetitive treatment of peritoneal metastases, which commonly occur in advanced gastrointestinal cancer and in
pancreatic cancer in particular. In case of diffuse intraperitoneal metastatic spread, Hyperthermic Intraperitoneal
Intraoperative Chemotherapy (HIPEC) is used as a therapeutic approach. Plasma-treated solutions may combine
non-toxic characteristics with the anticancer effects of HIPEC. Previous work has provided evidence for an anticancer
efficacy of plasma-treated cell culture medium but the clinical relevance of such an approach is low due
to its complex formulation and lack of medical accreditation.

Objective:

Plasma-treated Phosphate-Buffered Saline (PBS), which closely resembles medically certified solutions,
was investigated for its cytotoxic effect on 2D monolayer murine pancreatic cancer cells in vitro.

Methods:

Toxicity studies of primary murine fibroblasts, PDA6606 murine pancreatic cancer cells, and COLO
357 human pancreatic cancer cells exposed to plasma-treated PBS were performed.

Results:

Plasma-treated PBS significantly decreased cancer cell metabolisms and proliferation whereas
plasma-treated Dulbecco’s Modified Eagle Medium had no effect. Moreover, tumor cell growth attenuation was
significantly higher when compared to syngeneic primary murine fibroblasts. Both results were confirmed in a
human pancreatic cancer cell line. Finally, plasma-treated PBS also decreased the size of pancreatic tumors in a
three-dimensional manner, and induction of apoptosis was found to be responsible for all anticancer effects
identified.

Conclusion:

Plasma-treated PBS inhibited cell growth in 2D and 3D models of cancer. These results may help
facilitate the development of new plasma-derived anticancer agent with clinical relevance in the future.
An Outbreak of ESBL-producing Klebsiella pneumoniae in an Iranian Referral Hospital: Epidemiology and Molecular Typing
Authors: Mahmoudi Shima , Pourakbari Babak , Rahbarimanesh Aliakbar , Abdosalehi Mohammad Reza , Ghadiri Keyghobad , Mamishi Setareh
Published: May 2018

Introduction:

Klebsiella pneumoniae is a common cause of nosocomial infections; however, there is limited information in Iran regarding nosocomial outbreaks due to extended-spectrum β–lactamase (ESBL) producing K pneumoniae strains, particularly using molecular methods. The present study focused on the molecular mechanism of ESBL resistance and genetic relatedness in K. pneumoniae isolates causing nosocomial infections in an Iranian referral hospital.

Material and Methods:

This study evaluated the antimicrobial resistance and molecular epidemiology of K. pneumoniae causing nosocomial infections in children between October 2013 and March 2014. The ESBL detection was carried out for all the isolates by the CLSI method and PCR was carried out for the detection of the blaSHV, blaTEM, and blaCTX-M genes among ESBL-producing K. pneumonia. Molecular typing of the K. pneumoniae was performed using random amplification of polymorphic DNA-polymerase chain reaction (RAPD-PCR).

Results:

A total of 30 isolates of K. pneumoniae were used for epidemiological analysis. High rates of resistance to cefotaxime (n=29, 97%), cefazolin (n=29, 97%), cefepime (n=25, 83%) and gentamicin (n=23, 77%) were observed. A total of 29 strains (97%) produced ESBLs. The frequency of blaSHV, blaCTX-M and blaTEM genes among these isolates was 83% (n=25), 70% (n=21) and 57% (n=17), respectively. Surprisingly 11 isolated (37%) carried blaSHV, blaCTX-M and blaTEM genes simultaneously. Moreover, the concurrent presence of “blaSHV and blaCTX-M” and “blaSHV and blaTEM” was seen in 8 (27%) and 4 (13%) isolates, respectively. RAPDPCR analyses revealed that K. pneumoniae isolates belonged to 2 RAPD-PCR types among which one cluster counted for 28 isolates.

Conclusion:

To our knowledge, this is the first published report of a nosocomial outbreak of ESBL-producing K. pneumoniae in children in Iran. Although the epidemiology of nosocomial infections with ESBL-producing organisms has not yet been explored in depth in Iran, our findings suggest that ESBL-producing organisms are already an established public health threat in our country.
Expression of Phi11 Gp07 Causes Filamentation in Escherichia coli
Authors: Das Avijit , Biswas Sumit , Biswas Malabika
Published: May 2018

Background:

The Gp07 protein of aureophage Phi11 exhibits growth inhibitory effects when overexpressed inE. coli.The protein harbors two domains- an amino terminal Bro-like domain and a carboxy terminal Ant superfamily like KilA domain, of which the KilA domain retains the growth inhibitory effect of Gp07.

Methods:

We studied the effects exerted by the overexpression of Gp07 and its separate domains upon the growth rate as well as the morphology of theE. colicells. Additionally, we generated a mutant of Gp07 (designated as ΔGp07) by deleting the first eleven amino acid residues from the amino-terminal region of Gp07, and studied its growth inhibitory effects uponE. coli.

Results:

Our results indicate that Gp07, ΔGp07 as well as the Carboxy-terminal region of Gp07 upon overexpression, retards the growth rate of theE. colicells and also induces filamentation in the cells. Surprisingly, our data clearly suggests that the growth inhibition and filamentation induced by the the amino-terminal domain of Gp07 is temporal in nature.

Conclusion:

The carboxy-terminal of domain of gp07 is essential for its activity.
Oxytetracycline-Protein Complex: The Dark Side of Pet Food
Authors: Di Cerbo Alessandro , Scarano Antonio , Pezzuto Federica , Guidetti Gianandrea , Canello Sergio , Pinetti Diego , Genovese Filippo , Corsi Lorenzo
Published: May 2018

Background:

Worldwide antibiotic abuse represents a huge burden, which can have a deep impact on pet and human health through nutrition and medicalization representing another way of antibiotic resistance transmission.

Objective:

We aimed our research to determine a possible complex formation between biological bone substrates, such as proteins, and Oxytetracycline (OTC), an approved antibiotic for use in zootechny, which might determine a toxic effect on K562 cells.

Method:

Cell viability and HPLC-ESI/QqToF assays were used to assess potential toxicity of bone extract derived from OTC-treated chickens according to standard withdrawal times and from untreated chickens at 24, 48 and 72h of incubation.

Results:

Cell culture medium with ground bone from chickens reared in the presence of OTC (OTC-CCM) resulted significantly cytotoxic at every incubation time regardless of the bone concentration while cell culture medium with ground bone from chickens reared without OTC (BIO-CCM) resulted significantly cytotoxic only after 72h of incubation. HPLC-ESI/QqToF assay ruled out the possible presence of OTC main derivatives possibly released by bone within culture medium until 1 μg/mL.

Conclusion:

The presence of a protein complex with OTC is able to exert a cytotoxic effect once released in the medium after 24-48h of incubation.
Klincs kötés vizsgálata kísérleti és szimulációs úton
Authors: Jónás Szabolcs , Tisza Miklós
Published: May 2018

Ebben a cikkben DP600 jelű acélok klincs kötését vizsgáljuk kísérleti és szimulációs úton. A klincs kötés egy bélyeg és matrica szerszámpár segítségével, képlékeny alakváltozások során hozható létre vékonylemezek között. A lemezeket a bélyeg adott erővel a matricába nyomja. Az eljárás gyakorlatilag egy sajtolva lemezalakító technológia, amely a szerszámok geometriájának megfelelően hozza létre a kötést. A folyamat során a lemezek képlékeny alakváltozást szenvednek, és a kötésre jellemző „S” alakú alámetszés alakul ki.
A precíziós gazdálkodás kilátásai Magyarországon
Authors: Popp József , Erdei Edina , Oláh Judit
Published: May 2018

A mezőgazdaság számára a precíziós gazdálkodás jelentheti a jövőt, hiszen egyszerre járhat a jövedelmek növelésével és a környezetterhelés mérséklésével. A precíziós gazdálkodás statisztikailag igazolható többletet termel hozamban, bevételben, eredményben, de nem azonnal. A többletjövedelem potenciál 20-50% között várható. A precíziós gazdálkodásra főként azért térnek át a gazdaságok, hogy tehermentesítsék a dolgozókat. Sok gazdálkodó azonban még mindig tart az új technológiával működő eszközök használatától, pedig a mezőgazdaságban is megkerülhetetlen lesz az informatika alkalmazása. A technológia alapvetően drága, még nem elterjedt, sőt a gazdák a fokozatosság elvét követve csupán néhány technológiai elemet használnak, ráadásul az óvatosság jegyében a technológia mezőgazdasági területük csak egy részére terjed ki. A gazdaságoknak tehát meg kell tanulni a korábbinál precízebben gazdálkodni, nem csak a termőföldön, hanem fejben is.
De la rabia humana de origen canino y otras vergüenzas
Authors: Alvis Nelson
Published: May 2018

Colombia invierte cerca de diez puntos de su PIB en salud, sin embargo, sus indicadores de salud pública desdicen de la efectividad de su sistema sanitario. A las ya altas tasas de prevalencia e incidencia de patologías controlables o erradicables, como malaria, dengue clásico y hemorrágico, fiebre amarilla, tuberculosis, cólera y leishmaniasis, se agrega otra vergüenza: los brotes de rabia humana de origen canino recientemente observados en la región caribe colombiana. La rabia es una enfermedad letal transmitida al hombre por animales domésticos o silvestres producida por el virus rábico perteneciente al género Lyssavirus de la familia Rhabdoviridae, prevenible mediante vacunación. Los mecanismos para evitar muertes por rabia están desarrollados y bien descritos: a) cortar la cadena de transmisión del virus en especies domésticas (vacunación, manejo de poblaciones de perros y atención de focos); b) aplicación oportuna de tratamientos pre y post exposición a personas en riesgo; c) Vigilancia epidemiológica y monitoreo y control de la enfermedad en especies silvestres.
Enfermedad renal poliquistica asociada a linfoma extranodal en un canino
Authors: Echeverry Diego , Barbosa Ximena , Buriticá Edwin
Published: May 2018

Objetivo: Presentar el caso de un paciente canino, con enfermedad renal poliquística, asociada a linfoma extranodal. Materiales y métodos: Se estudió el caso de un paciente canino de raza Siberian Husky de 7 años de edad, al que se le encontraron múltiples nódulos renales bilaterales, con diagnóstico histopatológico de linfoma extranodal. Resultados: Se expone el caso clínico de un paciente canino de raza Siberian Husky, que es presentado a consulta dermatológica por exhibir lesiones alopécicas multifocales. Una vez realizado el examen físico sistemático se evidenció de manera incidental nefromegalia. Los exámenes paraclínicos e histopatológicos aplicados demostraron la presencia de enfermedad renal poliquística asociada a linfoma extranodal, como consecuencia se presento falla renal crónica. Conclusiones: El linfoma extranodal renal es una entidad patológica de rara presentación, clínicamente cursa con signos muy similares a otras alteraciones tumorales, su diagnóstico suele ser histopatológico.
Miectomía sacrococcigea ventral en equinos
Authors: Martínez Mastoby , Martínez Hernando , Sánchez Alba , Ballut Juan
Published: May 2018

Se realizó una técnica quirúrgica basada en una incisión pequeña del músculo sacrococcigeo ventral, con el fin de realzar la elegancia del caballo al andar teniendo presente los aspectos bioéticos de la medicina veterinaria. En los animales intervenidos no se presento complicación y se logró el objetivo, por lo que se propone esta técnica quirúrgica para que sea practicada por los veterianrios durante su ejercicio profesional.
Evaluación histológica de la reparación tisular posterior a la realización de técnicas de palatectomía parcial equina
Authors: Escobar Hamilton , Peniche Irina , Álvarez Leonardo , Martínez Mastoby
Published: May 2018

Objetivo. Evaluar la reparación tisular posterior a la realización de técnicas de palatectomía parcial, como tratamiento de la palatitis en equinos. Materiales y métodos. Se utilizaron 12 caballos, divididos aleatoriamente en dos grupos, ambos con seis animales, a los del primer grupo se les practicó palatectomía parcial con suturación y a los del segundo grupo, se les realizó palatectomía parcial y luego cauterización. Los grupos fueron divididos en tres subgrupos de dos animales cada uno. A los primeros subgrupos, suturados y cauterizados, se les tomó biopsia el día 5; a los segundos subgrupos, el día 15 y a los terceros el día 30 posquirúrgico. Resultados. El día 5 posquirúrgico, en ambos grupos se observó la presencia de infiltrado celular inflamatorio de tipo mononuclear (macrófago), inicio del proceso de epitelización, proliferación fibroblástica y formación de nuevos vasos sanguíneos; notándose severa ulceración del epitelio con abundantes detritos celulares solo en los animales cauterizados. El día 15 posquirúrgico, en los animales suturados, se observó infiltrado celular mononuclear, proliferación epitelial y fibroblástica, y presencia de nuevos vasos sanguíneos. Las muestras de los animales cauterizados, presentaron además, ulceración epitelial, detritus celulares y formación de tejido de granulación desorganizado. El día 30 posquirúrgico, los animales suturados, no mostraron inflamación evidente, el epitelio se observó con características normales aunque más grueso que el adyacente. En los animales cauterizados, no se observó infiltrado celular mononuclear, aunque continuaba la ulceración epitelial, igualmente existía, proliferación fibroblástica desorganizada y abundantes fibras colágenas. Conclusión. Es posible concluir que el proceso de reparación tisular se vio favorecido por la técnica de palatectomía parcial con suturación.
Measurement of Symptom Change Following Web-Based Psychotherapy: Statistical Characteristics and Analytical Methods for Measuring and Interpreting Change
Authors: Karin Eyal , Dear Blake F , Heller Gillian Z , Gandy Milena , Titov Nickolai
Published: May 2018

Background

Accurate measurement of treatment-related change is a key part of psychotherapy research and the investigation of treatment efficacy. For this reason, the ability to measure change with accurate and valid methods is critical for psychotherapy.

Objective

The aims of this study were to (1) explore the underlying characteristics of depressive symptom change, measured with the nine-item Patient Health Questionnaire (PHQ-9), following psychotherapy, and (2) compare the suitability of different ways to measure and interpret symptom change. A treatment sample of Web-based psychotherapy participants (n=1098) and a waitlist sample (n=96) were used to (1) explore the statistical characteristics of depressive symptom change, and (2) compare the suitability of two common types of change functions: linear and proportional change.

Methods

These objectives were explored using hypotheses that tested (1) the relationship between baseline symptoms and the rate of change, (2) the shape of symptom score distribution following treatment, and (3) measurement error associated with linear and proportional measurement models.

Results

Findings demonstrated that (1) individuals with severe depressive baseline symptoms had greater reductions in symptom scores than individuals with mild baseline symptoms (11.4 vs 3.7); however, as a percentage measurement, change remained similar across individuals with mild, moderate, or severe baseline symptoms (50%-55%); (2) positive skewness was observed in PHQ-9 score distributions following treatment; and (3) models that measured symptom change as a proportional function resulted in greater model fit and reduced measurement error (<30%).

Conclusions

This study suggests that symptom scales, sharing an implicit feature of score bounding, are associated with a proportional function of change. Selecting statistics that overlook this proportional change (eg, Cohen d) is problematic and leads to (1) artificially increased estimates of change with higher baseline symptoms, (2) increased measurement error, and (3) confounded estimates of treatment efficacy and clinical change. Implications, limitations, and idiosyncrasies from these results are discussed.
Barriers and Opportunities for Using Wearable Devices to Increase Physical Activity Among Veterans: Pilot Study (Preprint)
Authors: Kim Rebecca H , Patel Mitesh S
Published: May 2018

BACKGROUND

Few studies have examined the use of wearable devices among the veteran population.

OBJECTIVE

The objective of this study was to evaluate veterans’ perceptions of and experiences with wearable devices and identify the potential barriers and opportunities to using such devices to increase physical activity levels in this population.

METHODS

Veterans able to ambulate with or without assistance completed surveys about their mobile technology use and physical activity levels. They were then given the option of using a wearable device to monitor their activity levels. Follow-up telephone interviews were conducted after 2 months.

RESULTS

A total of 16 veterans were enrolled in this study, and all of them agreed to take home and use the wearable device to monitor their activity levels. At follow-up, 91% (10/11) veterans were still using the device daily. Veterans identified both opportunities and barriers for incorporating these devices into interventions to increase physical activity.

CONCLUSIONS

Veterans engaged in using wearable devices at high rates.
A Schema Therapy–Based eHealth Program for Patients with Borderline Personality Disorder (priovi): Naturalistic Single-Arm Observational Study (Preprint)
Authors: Jacob Gitta Anne , Hauer Andrea , Köhne Sandra , Assmann Nele , Schaich Anja , Schweiger Ulrich , Fassbinder Eva
Published: May 2018

BACKGROUND

Electronic health (eHealth) programs have been found to be effective in treating many psychological conditions. However, regarding borderline personality disorder (BPD), only a few eHealth programs have been tested, involving small interventions based on the dialectical behavior therapy treatment approach. We investigated priovi, a program based on the schema therapy (ST) approach. priovi is considerably more comprehensive than prior programs, offering broad psychoeducation content and many therapeutic exercises.

OBJECTIVE

We tested the acceptability and feasibility of priovi in 14 patients with BPD as an add-on to individual face-to-face ST.

METHODS

Patients received weekly individual ST and used priovi over a period of 12 months. We assessed BPD symptom severity using self-reported and interview-based measures. Qualitative interviews were conducted with both patients and therapists to assess their experiences with priovi.

RESULTS

BPD symptoms improved significantly (Cohen d=1.0). Overall, qualitative data showed that priovi was positively received by both patients and therapists. Some exercises provoked mild anxiety; however, no serious threat to safety was detected.

CONCLUSIONS

riovi is a potentially helpful and safe tool that could support individual ST. It needs to be further tested in a randomized controlled study.

CLINICALTRIAL

German Clinical Trials Register DRKS00011538; https://www.drks.de/drks_web/navigate.do? navigationId=trial.HTML&TRIAL_ID=DRKS00011538
The Survival of Reasonableness Review: Confirming the Boundaries
Authors: Jhaveri Swati
Published: May 2018

Predictions have been made about the inevitable demise of judicial review of executive action on the grounds of ‘reasonableness’ for some time. This is especially heightened as and when other substantive grounds of judicial review–for example, proportionality and review for material error of fact–emerge and gain traction. It is argued that these newer grounds are much better suited to the task of reviewing the substance of executive decision-making and they, therefore, reduce the appetite for reasonableness review. This paper considers attempts to retain such review in England, Australia and Canada, notwithstanding the flourishing of other substantive grounds of review. It evauates the reasons, particular to each jurisdiction, for retaining reasonableness review. In the English context, it could be a useful tool to slow down advances in the scope of review. In the Australian context, it could be a suitable vehicle for the incremental expansion of substantive review relative to proportionality, in a way that is not too disruptive of the relatively conservative approach to judicial review on questions of substance. In the Canadian context, it is the only counterpoint available to correctness as a standard of review in the area of substantive review. It could be argued that the retention of a standard of review–like reasonableness–that has a tendency towards deference is misplaced in an era where there appears to be a growing interest in strengthening a culture of justification in the executive through stronger judicial review. Here the aims of the paper are modest. It is not being suggested that reasonableness review should be the sole or primary ground for substantive review. Instead, the paper argues that there is some merit in retaining a tool that is more readily capable of a deferential application (relative to proportionality or correctness as standards of review). The merit of reasonableness review lies in its cautious approach rather than its potential to grow into a strong or sufficient tool of review and, indeed, it is not necessary for it to do so in today's substantive review landscape.
Preface
Authors: Sutomo Adi Heru , Graber Mark A.
Published: May 2018

1. The development of Primary Care Medicine is a reality that must soon be realized in all countries in the world, including Indonesia. For that reason alone the development of Primary Care Doctors or DLP in Indonesia does not need to be questioned any more. But many relevant questions remain. Related to this statement, if Indonesia does not want to be left behind by our neighbors, such as Myanmar, Vietnam, Malaysia, Singapore, Thailand, Australia, India, Pakistan, Japan, and others, the improvement of medical services at the primary level should be implemented immediately. Review of Primary Care Practice and Education (RPCPE) is a published journal that accommodates various activities related to current views and studies which relate to primary care at the local, regional, national or even international level, so from that perspective the RPCPE is published. We invite and encourage anyone and from anywhere to contribute their ideas, thoughts or ideas concerning the content of this journal. Please send your criticisms and suggestions as well as any responses to the posts contained in this journal. We welcome your input for the future of DLP....... By Adi Heru Sutomo 2. Welcome to the inaugural issue of “Review of Primary Care Practice and Education” (RPCPE), the Indonesian, journal dedicated to the science and practice of Primary Care.  The recognition of Primary Care Doctors as a specialty by the government and other specialty boards has been a long time coming.  It is a great step forward for Primary Care, Primary Care Doctors and more importantly, for the people of Indonesia. Finally, this is an acknowledgment of your expertise in primary care and of all of the hard work you do every day for your patients. Recognition at the national level is only a first step.  We now have the task of developing training programs and certifications for those physicians who are already in practice..... By Mark A. Graber
Impact of Training by Family Doctor on Cadre Performance in Counseling at Posbindu Dusun Tahunan of Gunungkidul Regency
Authors: Hadiyanta T. Herjuna , Istiono Wahyudi , Pramantara I Dewa Putu
Published: May 2018

Background: Increasing cases of non-communicable diseases (NCDs) are becoming a serious public health threat because they dominate the top 10 global causes of death. The government is trying to control it by way of early detection of NCDs risk factors through Posbindu (Integrated Coaching Groups) activities. At this time Posbindu programs are not running optimally because the volunteers called cadres (Kader) are not confident in doing counseling. Cadres find it difficult to read and understand the modules by themselves, while special training on counseling has not been prioritized. Optimally, family doctors as community oriented care providers need to train cadres to be skilled in counseling so that risk factors can be controlled as early as possible.Objectives: The purpose of this study was to assess whether the impact of role playing training by family physicians can improve the volunteer cadres’ performance in providing counseling compared with those who rely on only reading the modules.Methods: The design of this study was a quasi-experimental research with a sample size of 50 participants. The treatment was provided in the form of counseling to 11 volunteers (cadres) who were specially trained. Analysis of pre and post-test data used a variety of tests (t-test).Results: Cadres who were trained by family physicians showed a significant increase in mean knowledge level (p value 0.007) of 22.9. An average increase 4 weeks after training showed no significant difference (p value 0.346) when compared to results immediately after the training. Knowledge of cadres only reading the module showed no significant mean difference (p value 0.6871). There was a significant difference of mean knowledge between the trained cadres which was higher than the cadres who only read the modules (p value 0.005). There was also a significant increase in the average knowledge of participants after receiving counseling by trained cadres (p value 0.001) of 22.28.Conclusion: There was a significant increase in cadre knowledge about NCDs risk factors after being specially trained by family physicians. Knowledge of cadres before and after being given modules without training showed no significant change. There was also a significant increase in participants’ knowledge after receiving counseling by trained cadres. Training of cadres with role playing methods was demonstrated to increase participants’ knowledge significantly and can be considered a determinant of success in improving cadre performance in counseling.
Case Report: Type 2 Diabetes Mellitus
Authors: Hesfianto Shofi
Published: May 2018

.......A patient who was first diagnosed with a chronic disease often does not fully understand the meaning or significanceof the chronic disease with which his/ her body suffers, against the risk of future complications if the disease is not well-controlled. On the other hand, in this reported case, the patient’s expectation was that her chronic disease, the T2DM, can be cured. Therefore, a shared understanding between health care providers and patient is likely the key to commencing the course of managing any chronic disease in a patient effectively.......
HISTÓRIA ANUNCIADA: CRÔNICAS DE CAMILLO DE JESUS LIMA, UM INTELECTUAL “DE ESQUERDA”
Authors: Meira Esmeralda Guimarães , Almeida José Rubens Mascarenhas de
Published: May 2018

Este artigo apresenta parte dos resultados de um estudo sobre Camillo de Jesus Lima (1912 - 1975), escritor de contos, críticas, romances, crônicas e poesias. Teve sete livros publicados entre 1941 e 1973, sendo vencedor do prêmio Raul de Leoni, em 1942, pela Academia Carioca de Letras, com o livro Poemas, mas grande parte de sua extensa obra em prosa e em verso permanece inédita. A escrita camilliana ocupou as páginas dos jornais em meados do século XX, quando atuou como redator, crítico de rodapé e cronista. Por algum tempo esteve engajado na luta socialista, fazendo sempre da pena uma arma de combate. Lutou contra a exploração, defendendo a liberdade e a igualdade social, tanto em sua militância política, como na sua produção literária. O propósito deste recorte é reconhecer a sua concepção crítica de mundo, uma revelação da memória histórica e de uma obra silenciada e esquecida. A análise da relação entre literatura e história que aqui realizamos fundamenta-se na dialética marxista, tomando como fonte documentos do arquivo pessoal do escritor, em especial, crônicas publicadas no jornal O Combate, nos anos 1944 e 1947. Trata-se de um convite à leitura da crítica que o autor fez da história do seu momento histórico (final da segunda guerra mundial e imediato pós-guerra) sob uma perspectiva socialista ou, como dito por ele, “de esquerda”. O artigo busca resgatar a intensa participação do intelectual Camillo de Jesus Lima no panorama literário brasileiro do século XX, voz que reverbera atual nos nossos dias, por meio de sua obra, principalmente, no concernente à relação história e literatura.
LA MATEMÁTICA Y SU INTERRELACIÓN CON EL ARTE Y OTRAS DISCIPLINAS
Authors: Carrera Elena Fernández de , Casimiro Ana Palmira Bittencourt Santos
Published: May 2018

En este artículo se presenta una visión de la universalidad de la matemática, y su relación con algunas expresiones artísticas. Su presencia se detecta en la cultura de los pueblos, según puede rastrearse desde la antigüedad hasta nuestros días. Lo hace desde un doble aspecto. El primero intenta mostrar cómo descubrir la presencia de la matemática en las manifestaciones de arte; y el segundo, cómo el artista ve la matemática desde su óptica. Se hace hincapié en la arquitectura de la actualidad con arquitectos como Le Corbusier, Oscar Niemeyer, Gaudí y Iannis Xenakis. En verdad, la matemática tiene cierta analogía con todas las formas conocidas de arte, pero también con la ciencia, incluyéndose la medicina.