bluuebunny/crossref_metadata_2025 huggingface dataset:
Validation of a Core Patient-Reported Outcome Measure for Fatigue in Patients Receiving Hemodialysis
Authors: Ju Angela , Teixeira-Pinto Armando , Tong Allison , Smith Alice C. , Unruh Mark , Davison Sara N. , Dapueto Juan , Dew Mary Amanda , Fluck Richard , Germain Michael J. , Jassal Sarbjit V. , Obrador Gregorio T. , O’Donoghue Donal , Viecelli Andrea K. , Strippoli Giovanni , Ruospo Marinella , Timofte Delia , Sharma Ankit , Au Eric , Howell Martin , Costa Daniel S.J. , Anumudu Samaya , Craig Jonathan C. , Rutherford Claudia
Published: October 2020

Background and objectives

Fatigue is a very common and debilitating symptom and identified by patients as a critically important core outcome to be included in all trials involving patients receiving hemodialysis. A valid, standardized measure for fatigue is needed to yield meaningful and relevant evidence about this outcome. This study validated a core patient-reported outcome measure for fatigue in hemodialysis.

Design, setting, participants, & measurements

A longitudinal cohort study was conducted to assess the validity and reliability of a new fatigue measure (Standardized Outcomes in Nephrology-Hemodialysis Fatigue [SONG-HD Fatigue]). Eligible and consenting patients completed the measure at three time points: baseline, a week later, and 12 days following the second time point. Cronbach α and intraclass correlation coefficient were calculated to assess internal consistency, and Spearman rho was used to assess convergent validity. Confirmatory factor analysis was also conducted. Hemodialysis units in the United Kingdom, Australia, and Romania participated in this study. Adult patients aged 18 years and over who were English speaking and receiving maintenance hemodialysis were eligible to participate. Standardized Outcomes in Nephrology-Hemodialysis, the Visual Analog Scale for fatigue, the 12-Item Short Form Survey, and Functional Assessment of Chronic Illness Therapy–Fatigue were used.

Results

In total, 485 participants completed the study across the United Kingdom, Australia, and Romania. Psychometric assessment demonstrated that Standardized Outcomes in Nephrology-Hemodialysis is internally consistent (Cronbach α =0.81–0.86) and stable over a 1-week period (intraclass correlation coefficient =0.68–0.74). The measure demonstrated convergence with Functional Assessment of Chronic Illness Therapy–Fatigue and had moderate correlations with other measures that assessed related but not the same concept (the 12-Item Short Form Survey and the Visual Analog Scale). Confirmatory factor analysis supported the one-factor model.

Conclusions

SONG-HD Fatigue seems to be a reliable and valid measure to be used in trials involving patients receiving hemodialysis.
Review of the Textbook “Fundamentals of the Digital Economy”
Authors: Yanova S. Yu.
Published: October 2020

The review examines the textbook edited by M. N. Konia- gina, dedicated to the new and acutely relevant discipline “Fundamentals of the digital economy.” The structure of the textbook is considered, particularly interesting chapters are highlighted, the contribution of the co-authors not only to the textbook itself, but also to the development of thematic areas presented by the publication’s chapters is highlighted, which is confirmed by the numerous published works of the co-authors. The reviewer gives an overall high positive assessment of the peer-reviewed work, as well as recommendations for further deepening the topics being studied.

The author of the review is convinced that the textbook will be useful to students of the educational areas of Econom­ics, Management, Business Informatics, State and Mu­nicipal Administration, teachers, business representatives in the process of corporate digital transformation, self­development, and organization of development processes for company employees.
Professional competencies in engineering education: the PREFERed-way
Authors: Langie Greet , Craps Sofie
Published: October 2020

Professional competencies vary across engineering job characteristics. The design of the educational environment should take into account this diversity and enable students to develop career awareness. The European project PREFER (Professional Roles and Employability for Future EngineeRs) has developed instruments to make engineering students aware of the existence of professional roles and their associated competency profiles. These are designed and validated in strong interaction with industry, guaranteeing a discipline-independent, future-proof framework that is ready to implement in the engineering curriculum. In this paper, we describe the integration of this framework in the Faculty of Engineering Technology of KU Leuven, Belgium. The selection of professional competencies based on professional roles, the adaptive level of the professional competencies thanks to electives and the collaborative assessment of the students by experts in professional competencies and experts in technological competencies, are key elements of the new engineering curriculum. All of them are developed thanks to a university-business collaboration. The reformed curriculum will start from the academic year 2020-2021.
Trust in robot futures: The role of sociotechnical potential
Authors: Pagter Jesse de
Published: October 2020

The aim of this paper is to develop an approach that conceptualizes the role of sociotechnical potential in the discourse around trust in emerging technology. Thereby it focuses on robotics as an example of an emerging technology which is subject to many expectations concerning its future. The paper first provides a general overview of the thinking on trust in philosophy of technology. In the section after that, the paper argues for the importance of adding the perspective of technological potential by emphasizing how the discourse around emerging technologies like robotics is often referring to a world-to-come. Based on this idea, the final section argues for an approach to trust in technology that is based on the perspective of multiplicity of technology narratives. As such, the goal is to build and foster trust in the future of robots based on a notion of technodiversity.
Newly graduate engineers’ development of expertise and personal competencies
Authors: Pyrhönen Veli-Pekka , Niiranen Sonja , Pajarre Eila
Published: October 2020

This paper investigates importance and development of expertise and personal competencies of newly graduated engineers according to academic staff members, industrial employers and the graduated engineers themselves. The aim was to discover how graduated engineers perceive the importance of competencies at the time of graduation, and how various competencies have developed during their studies. For such purposes, a national-wide graduate survey was adopted as a basis for research. The results show that engineering degree programmes highlight theoretical
foundation rather than generic competencies, whereas industrial employers favor personal competencies and attitudinal factors. Furthermore, according to graduates’ ratings, some competencies have developed more than appears to be necessary at the beginning of their career. These competencies were the most valued in degree programmes. Similarly, some competencies that were least valued in degree programmes were part of the least developed competencies in studies, but also part of the most important competencies for graduates.
Analog Electronic Circuits to Model Cooperativity in Hill Process
Authors: Waqas Maria , Khurram Muhammad , Hasan S.M. Razaul
Published: October 2020

In the field of computational biology, electronic modeling of bio-cellular processes is in vogue for about a couple of decades. Fast, efficient and scalable electronic mimetics of recurrently found bio-chemical reactions are expected to provide better electronic circuit simulators that can also be used as bio-sensors or implantable biodevices at cellular levels. This paper presents some possible electronic circuit equivalents to model dynamics of one such bio-chemical reaction commonly involved in many bio-cellular processes, specifically pathways in living cells, known as the Hill process. The distinguishing feature of this process is cooperativity which has been modeled in silicon substrate using a pair of transistors, one transistor driving current in the other the same way ligand binding to one receptor site controls the binding affinity of the other receptor sites. Two possible circuits have been proposed and compared to electronically model cooperativity of a Hill reaction. The main idea is to exploit the natural analogies found between structures and processes of a bio-cell and electronic transistor mechanics, to efficiently model fundamental bio-chemical reactions found recurring in bio-processes. These circuits can then be combined and rearranged quickly to form larger, more complex bio-networks, thus mitigating the intricacies involved in modeling of such systems.
Modeling, Control and Placement of FACTS Devices: A Review
Authors: Haroon Ayesha , Javed Irfan Shafqat , Baig Huma Rehmat , Nasir Ali
Published: October 2020

Over the past two decades, developing distributed energy sources in electric power grid have created new challenges related to the power quality, voltage adjustment and proficient energy utilization. Power electronic converters are widely used to interface the emerging energy systems (without and with energy storage) and smart buildings with the transmission and distribution systems. Flexible Ac Transmission Systems (FACTS) and Voltage-Source Converters (VSC), with smart dynamic controllers, are emerging as stabilization and power filtering equipment to improve the power quality. FACTS devices are of vital significance for tackling the problem of voltage instability which is inevitable and leads to losses in transmission system networks. These devices provide fast voltage regulation, ensure system stability and reactive power compensation. In this regard, modeling, control and appropriate placement of these devices in the transmission lines have been of great importance for researchers of power transmission systems. By using high speed power electronic converters, FACTS perform many times faster than the conventional compensation techniques. FACTS not only provide fast voltage regulation but also damping of active power oscillations and reactive power compensation. Hence, they increase the availability and reliability of the power systems. But, the functioning of a FACTS device extremely reckons upon its parametric quantity, appropriate placement, and sizing in the power network. In this paper, an extensive literature survey is presented to discuss and investigate these parameters of FACTS devices.
Collocation Method for Multiplicative Noise Removal Model
Authors: Ahmad Khan Mushtaq , Khan Zawar Hussain , khan Haseeb , Khan Sheraz , Khan Suhail
Published: October 2020

Image denoising is a fundamental problem in both image processing and computer vision with numerous applications. It can be formulated as an inverse problem. Variational methods are commonly used to solve noise removal problems. The Total Variation (TV) regularization has evolved from an image denoising method for images corrupted with multiplicative noise into a more general technique for inverse problems such as denoising, deblurring, blind deconvolution, and inpainting, which also encompasses the Impulse, Poisson, Speckle, and mixed noise models. Multiplicative noise removal based on TV regularization has been widely researched in image science. In multiplicative noise problems, original image is multiplied by a noise rather than added to the original image. This article proposes a novel meshless collocation technique for the solution of a model having multiplicative noise. This technique includes TV and local collocation along with Multiquadric Radial Basis Function (MQ-RBF) for the solution of associated Euler-Lagrange equation for restoring multiplicative noise from digital images. Numerical examples demonstrate that the proposed algorithm is able to preserve small image details while the noise in the homogeneous regions is removed sufficiently. As a consequence, our method yields better denoised results than those of the current state of the art methods with respect to the Peak-Signal to Noise Ratio (PSNR) values.
Performance Assessment of QoS Using AODV, TORA and ZRP Routing Protocol in MANET
Authors: Ahmad Irfan , Masood Fahad , Khan Arbab Wajid Ullah
Published: October 2020

In Mobile Ad hoc Networks (MANET) nodes often change their location independently where neither fixed nor centralized infrastructure is present. Nodes communicate with each other directly or via intermediate nodes. The advantages of the MANET layout lead to self-structure and compatibility to most important functions such as traffic distribution and load balancing. Whenever the host moves rapidly in the network the topology becomes updated due to which the structure of MANET varies accordingly. In the literature, different routing protocols have been studied and compared by researchers. Still, there are queries regarding the performance of these protocols under different scenarios. MANETs are not based on a predesigned structure. In this paper, the performance assessment of the Quality of Services (QoS) for different protocols such as Ad hoc On-Demand Distance Vector (AODV), Temporally Ordered Routing Algorithm (TORA) and Zone Routing Protocol (ZRP) in the existence of the various number of communicating nodes is studied. The performance matrices throughput, end – to – end delay and packet delivery ratio are considered for simulations. Ns 2.35 simulator is used for carrying out these simulations. Results are compared for AODV, TORA, and ZRP routing protocols. The results show that AODV and TORA perform well in end – to – end delay as compared to zone routing protocol. Zone routing protocol performs well in packet delivery ratio and throughput as compared to both the other protocols.
Recognition and Effective Handling of Negations in Enhancing the Accuracy of Urdu Sentiment Analyzer
Authors: Mukhtar Neelam , Khan Mohammad Abid , Chiragh Nadia , Jan Asim Ullah , Nazir Shah
Published: October 2020

Although work has been done in Urdu Sentiment Analysis by researchers but still there is a lot of room for improvement in the form of achieving higher accuracy. Therefore, in this research, the accuracy of Urdu Sentiment Analysis in multiple domains is enhanced by dealing negations using Lexicon-based approach, one of the broadly used approaches for performing Sentiment Analysis. Negations in Urdu Sentiment Analysis are particularly focused in this research because of their effective role in Sentiment Analysis. Both local and long distance negations are considered. For achieving this goal, a corpus with 6025 Urdu sentences, from 151 blogs that belong to 14 different genres is taken in which use of negations is carefully observed. Two major steps are taken in this regard. First, to deal with the morphological negations, this type of negations is included in the negative word file of the Urdu Sentiment Lexicon developed for performing Sentiment Analysis of Urdu blogs. Secondly, rule-based approach is used for handling the implicit and explicit negations. Rules are designed that can deal with both implicit and explicit negations effectively. Implementation of these rules increased the accuracy of Sentiment Analyzer from 73.88% to 78.32% with 0.745, 0.788 and 0.745 Precision, Recall and Fmeasure respectively, which is statistically significant improvement.
Computer Simulation Based Optimization of Aspect Ratio for Micro and Nanochannels
Authors: Afzal Muhammad Javaid , Ashraf Muhammad Waseem , Tayyaba Shahzadi , Jalbani Akhtar Hussain , Javaid Farah
Published: October 2020

For Computational Fluidic Dynamics (CFD) analysis, different types of software are available such as ANSYS, COMSOL, GAMBIT and ABAQUS. ANSYS FLUENT is a very influential CFD software that enables the researchers to execute advanced and fast simulation as the performance of product is optimized. In this research work, the capabilities of ANSYS FLUENT have been investigated through the fluidic simulation of nano scale channels. Here, the simulation of three straight shaped and one curvilinear nano channel has been performed to analyze the precision of simulation with the aspect ratio of smaller dimensions (radius, length). The accurate dimensions have been determined for various shapes of channels. For straight circular channel, the radius of 124.9 µm and length of 900 µm are the dimensions found for error free simulations with 7.20 aspect ratio. While for straight crossed channel, the radius of 5.1 mm and length of 100 mm are the accurate dimensions for error free simulations with 19.60 aspect ratio. Width and depth are determined as 180 µm with 180 µm length in case of straight square channel for error free simulations with 1.0 aspect ratio. Finally, in case of curvilinear channel for error free simulations, the radius and length are found 22 and 209.1 µm respectively with 9.50 aspect ratio. None of the channels is found fit for simulation in nanometer range. Even in micrometer range, the simulations of these channels have acquired errors. Moreover, it has been observed that the aspect ratio is different for different geometries of microchannels for error free simulation.
A Comparative Study on Daylight Performance Assessment of Light Shelves Based on Inclination
Authors: Noshin Sadaf , Kanwal Humaira , Ahmad Abrar
Published: October 2020

Energy consumption of lighting can be reduced by using different daylight control strategies. The rise in environmental distresses requires the necessity of natural light control systems. Light shelf is considered as excellent lighting control scheme that provides great lighting production and inexpensive prospect via entering the daylight inside the space. The aims of this study shows that the daylight efficiency and visual productivity are affected by the design parameters of light shelf such as its angle, location and height. In this research, Autodesk Ecotect 2011 is used for the daylight simulation of summer solstice and winter solstice days under overcast sky conditions on a nominated theoretical study space of an institutional building. Daylight simulation is carried out to evaluate the illuminance requirement within the selected space and analysis is also executed on the model with selected categories of light shelves including different positions, heights and angles. The acquired data is then exported on Radiance software intended for complete day-light investigation. The results of this research shows that external light shelf at a height of 7' and an angle of 20˚ is the most appropriate choice in prevailing the glare and it also enhanced the illuminance level to11.5% in 21st June and 10.6% in 21st December as compared to without light shelves. Furthermore, the shaded range is decreased by the rise in the angle of Light shelf which has a tendency to increase the inside average lighting. Hence, significant consideration should be given to the height and position of light shelves, since it has a superior effect on light shelf performance.
A Lean Agile Resilient Green Implementation and Technology Utilization: A New Vision in Technology Adoption
Authors: Rafique Muhammad Zeeshan , Qureshi Hamid Iftikhar , Malkana Muhammad Umar , Mustafa Haider Syed , Atif Muhammad
Published: October 2020

Lean Manufacturing is always important for process improvement in manufacturing industries especially in deem of adoption but the implementation of simple lean is not enough to attain required results. A recent trend has been observed regarding the implementation of strategies like Lean, Agile, Resilient and Green (LARG) in combination to attain fruitful results. However, this combination carries a complication regarding its understanding and implementation and a gap observed regarding the availability of literature study that can cope all these strategies on one platform for understanding and can suggest a proper implementation method. It has been observed that there are some new models that are utilizing electronic configurations to provide powerful platform for process improvements. Utilization of LARG as tool or technique in combination of technologies can be very effective for process improvements. Therefore, this current work emphasis on the combining of LARG along with wireless technologies for obtaining a sustainable improvement in manufacturing sector, which seems unavailable. Based on this ideology, the aim of this research is to conduct a systematic literature study that reviews the previously available LARG research with the objectives to first study the LARG combination for understanding and to develop the interrelation between LARG and previous available technologies for its successful implementation. The literature study results that the LARG combination has many benefits like helpful to attain elimination of non-value activities (lean), responsive to the changing demands of customers as per increasing volatile market (agile), responsive to the unexpected disruptions (resilient) and to adopt environmental protection (green) but typically lacks its utilization with modern technologies (Like RFID) that will be helpful to attain successful implementation. The contribution of this study is the next generation in LARG implementation to emphasis more on the combining of LARG implementation with utilization of modern technologies
A Review of Automatic Travel Mode Detection Methods
Authors: Shafique Muhammad Awais , Hato Eiji
Published: October 2020

Household trip data is of crucial importance for managing present transportation infrastructure as well as to plan and design future facilities. It also provides basis for designing new policies, implemented under Transportation Demand Management, and assessing their effectiveness. With passage of time, methods used for household trip data collection have evolved, starting from the conventional face-to-face interviews or paperand-pencil interviews, moving on to mail-back surveys and internet-based surveys, before finally reaching to the recent approach of passive data gathering. Recording travel data automatically will require the use of modern technology present in the form of various sensors, and employing intelligent algorithms to infer the required information from these sensors’ data. These sensors can be integrated into a purpose-built device or more recently can be present in smartphones. The current study provides a comprehensive review of the research done in the field of travel mode detection from data passively collected with the help of various devices. The review starts from Global Positioning System (GPS) loggers and moves to cover purpose-built wearable devices containing additional sensors and finally ending with the most modern approach of incorporating smartphones. The summary tables presented in this study are of great value to the researchers trying to get insight of this research field.
Influence of Harvesting Methods and Timings on Yield and Quality of Selected Bread Wheat Varieties
Authors: Lund Muhammad Mithal , Keerio Muhammad Ibrahim , Tunio Shamsuddin , Gandahi Allah Wadhayo , Rajpar Inayatullah
Published: October 2020

An experiment was executed at experimental farm of Sindh Agriculture University Tandojam to quantify the losses in grain yield and quality of wheat in relation to time and method of harvesting. The experiment involved three bread wheat varieties (Kiran-95, Mehran-89 and TD-1) and two harvesting methods; conventional method using Sickle and mechanized method using Reaper. The harvesting times considered were: 5-days-before-maturity (DBM), 5-Days-after-maturity (DAM), 10 DAM, and 15 DAM. The data were recorded for grain yield, yield components (harvest index, seed index, etc.) and some grain quality traits (shriveled & broken grain losses). The results highlighted that, harvesting with reaper was most effective and economical in terms of losses to grain yield and quality over sickle (manual) method of harvesting. Compared to the other harvesting times tested in this study, the wheat crop harvested at proper physiological maturity (5 DAM) was found to be most effective and beneficial to maintain quality and obtain maximum grain yield. Generally, wheat crop harvested through conventional method using sickle showed more harvesting losses at different harvesting intervals. Among three wheat cultivars, the cultivar TD-1 harvested with sickle (manual method) at proper maturity, 5 DBM and 5, 10 and 15 DAM showed 5.55%, 6.54%, 7.09%, 8.06% and 9.45% harvesting losses; and 8.79%, 10.46%, 10.67%, 11.76% and 13.25% hauling losses, respectively. Contrarily, when same cultivar TD-1 was harvested through mechanized method using reaper, the respective treatment plots showed 5.35%, 6.09%, 6.21%, 7.07% and 8.49% harvesting losses, and 8.57%, 9.89%, 9.54%, 10.45% and 11.99% hauling losses to grain yield, respectively. This study suggests that wheat crop should be harvested with reaper at proper physiological maturity. Among the three bread wheat varieties included in the study, the variety Kiran-95 proved to be the most resistant to grain yield and quality losses.
ETV5 Regulates Hepatic Fatty Acid Metabolism Through PPAR Signaling Pathway
Authors: Mao Zhuo , Feng Mingji , Li Zhuoran , Zhou Minsi , Xu Langning , Pan Ke , Wang Shaoxiang , Su Wen , Zhang Weizhen
Published: October 2020

ETV5 is an ETS transcription factor that has been associated with obesity in genomic association studies. However, little is known about the role of ETV5 in hepatic lipid metabolism and nonalcoholic fatty liver disease. In the current study, we found that ETV5 protein expression was increased in diet- and genetically induced steatotic liver. ETV5 responded to the nutrient status in a mammalian target of rapamycin complex 1 (mTORC1)–dependent manner and in turn, regulated mTORC1 activity. Both viral-mediated and genetic depletion of ETV5 in mice led to increased lipid accumulation in the liver. RNA sequencing analysis revealed that peroxisome proliferator–activated receptor (PPAR) signaling and fatty acid degradation/metabolism pathways were significantly downregulated in ETV5-deficient hepatocytes in vivo and in vitro. Mechanistically, ETV5 could bind to the PPAR response element region of downstream genes and enhance its transactivity. Collectively, our study identifies ETV5 as a novel transcription factor for the regulation of hepatic fatty acid metabolism, which is required for the optimal β-oxidation process. ETV5 may provide a therapeutic target for the treatment of hepatic steatosis.
Type 2 Diabetes and COVID-19–Related Mortality in the Critical Care Setting: A National Cohort Study in England, March–July 2020
Authors: Dennis John M. , Mateen Bilal A. , Sonabend Raphael , Thomas Nicholas J. , Patel Kashyap A. , Hattersley Andrew T. , Denaxas Spiros , McGovern Andrew P. , Vollmer Sebastian J.
Published: October 2020

OBJECTIVE

To describe the relationship between type 2 diabetes and all-cause mortality among adults with coronavirus disease 2019 (COVID-19) in the critical care setting.

RESEARCH DESIGN AND METHODS

This was a nationwide retrospective cohort study in people admitted to hospital in England with COVID-19 requiring admission to a high dependency unit (HDU) or intensive care unit (ICU) between 1 March 2020 and 27 July 2020. Cox proportional hazards models were used to estimate 30-day in-hospital all-cause mortality associated with type 2 diabetes, with adjustment for age, sex, ethnicity, obesity, and other major comorbidities (chronic respiratory disease, asthma, chronic heart disease, hypertension, immunosuppression, chronic neurological disease, chronic renal disease, and chronic liver disease).

RESULTS

A total of 19,256 COVID-19–related HDU and ICU admissions were included in the primary analysis, including 13,809 HDU (mean age 70 years) and 5,447 ICU (mean age 58 years) admissions. Of those admitted, 3,524 (18.3%) had type 2 diabetes and 5,077 (26.4%) died during the study period. Patients with type 2 diabetes were at increased risk of death (adjusted hazard ratio [aHR] 1.23 [95% CI 1.14, 1.32]), and this result was consistent in HDU and ICU subsets. The relative mortality risk associated with type 2 diabetes decreased with higher age (age 18–49 years aHR 1.50 [95% CI 1.05, 2.15], age 50–64 years 1.29 [1.10, 1.51], and age ≥65 years 1.18 [1.09, 1.29]; P value for age–type 2 diabetes interaction = 0.002).

CONCLUSIONS

Type 2 diabetes may be an independent prognostic factor for survival in people with severe COVID-19 requiring critical care treatment, and in this setting the risk increase associated with type 2 diabetes is greatest in younger people.
Time in Range in Relation to All-Cause and Cardiovascular Mortality in Patients With Type 2 Diabetes: A Prospective Cohort Study
Authors: Lu Jingyi , Wang Chunfang , Shen Yun , Chen Lei , Zhang Lei , Cai Jinghao , Lu Wei , Zhu Wei , Hu Gang , Xia Tian , Zhou Jian
Published: October 2020

OBJECTIVE

There is growing evidence linking time in range (TIR), an emerging metric for assessing glycemic control, to diabetes-related outcomes. We aimed to investigate the association between TIR and mortality in patients with type 2 diabetes.

RESEARCH DESIGN AND METHODS

A total of 6,225 adult patients with type 2 diabetes were included from January 2005 to December 2015 from a single center in Shanghai, China. TIR was measured with continuous glucose monitoring at baseline, and the participants were stratified into four groups by TIR: >85%, 71–85%, 51–70%, and ≤50%. Cox proportional hazards regression models were used to estimate the association between different levels of TIR and the risks of all-cause and cardiovascular disease (CVD) mortality.

RESULTS

The mean age of the participants was 61.7 years at baseline. During a median follow-up of 6.9 years, 838 deaths were identified, 287 of which were due to CVD. The multivariable-adjusted hazard ratios associated with different levels of TIR (>85% [reference group], 71–85%, 51–70%, and ≤50%) were 1.00, 1.23 (95% CI 0.98–1.55), 1.30 (95% CI 1.04–1.63), and 1.83 (95% CI 1.48–2.28) for all-cause mortality (P for trend <0.001) and 1.00, 1.35 (95% CI 0.90–2.04), 1.47 (95% CI 0.99–2.19), and 1.85 (95% CI 1.25–2.72) for CVD mortality (P for trend = 0.015), respectively.

CONCLUSIONS

The current study indicated an association of lower TIR with an increased risk of all-cause and CVD mortality among patients with type 2 diabetes, supporting the validity of TIR as a surrogate marker of long-term adverse clinical outcomes.
Aplikasi Pengenalan Fakultas Komunikasi dan Informatika Universitas Muhammadiyah Surakarta menggunakan Virtual Reality 360 Derajat
Authors: Zulmi Abu Nizar , Fadlilah Umi
Published: October 2020

Teknologi merupakan aspek yang sangat penting di era modernisasi ini, hampir disetiap lini kehidupan memerlukan bantuan teknologi untuk mempermudah pekerjaan. Melalui teknologi, hampir setiap informasi diseluruh dunia dapat diakses dengan mudah dan cepat. Informasi yang didapat tidak hanya sekedar berbentuk tulisan saja, namun dapat juga dalam bentuk lain seperti foto atau gambar. Salah satu jenis teknologi foto yaitu foto Virtual Reality (VR) 360 derajat, seseorang dapat merasakan seolah-olah ada di dunia nyata melalui teknologi ini. Penulis menggunakan teknologi ini untuk memperkenalkan Fakultas Komunikasi dan Informatika Universitas Muhammadiyah Surakarta (FKI UMS) kepada mahasiswa yang benar-benar belum mengetahui tempat-tempat yang ada di fakultas mereka sendiri. Penulis membuat aplikasi ini sebagai media interaktif dengan menambahkan suara narasi, mode VR, denah lantai, dan fitur lainnya. Aplikasi berbasis web ini dibuat dengan 2 aplikasi utama yaitu Kolor AutoPano Giga dan Kolor Panotour Giga serta aplikasi pendukung lainnya. Pembuatan aplikasi ini menggunakan metode Luther Sutopo, metode ini memiliki beberapa tahapan yaitu Konsep, Desain, Pengumpulan Data, Pembuatan, Pengujian, dan Distribusi. Berdasarkan hasil pengujian kepada mahasiswa/mahasiswi FKI UMS dapat disimpulkan bahwa rata-rata sebanyak 86,89% responden menyatakan bahwa aplikasi ini dapat bermanfaat dan membantu mengenal lebih dalam tentang FKI UMS.
Hybrid Geographies of Global Genres: The Global Space in the Romanian Modern Novel
Authors:   Babeş-Bolyai University, Cluj-Napoca, Romania (daiana.gardan@lett.ubbcluj.ro), Gârdan Daiana
Published: October 2020

My paper aims to investigate an early phase of the globalization phenomenon as it has manifested in a specific peripheral space, attempting to map, by means of both close and distant reading, how the internalization processes have been mirrored in the modern Romanian novel. The scope of my research revolves around the responses that Romanian literature – a peripheral, minor literature – has had towards transnational or global models, and how the novelistic production of the aforementioned timeframe has metabolised and illustrated the foreign input in our culture. The theoretical framework of the present
Introducción al dossier: Chile, hasta que la dignidad se haga costumbre. Movilización social, proceso constituyente y horizontes de posibilidad post 18 de octubre
Authors: Alvarado Lincopi Claudio , Robles Recabarren Javiera
Published: October 2020

Introducción al dossier: Chile, hasta que la dignidad se haga costumbre. Movilización social, proceso constituyente y horizontes de posibilidad post 18 de octubre
“A nosotras nos han sentenciado a abrazar estos pedacitos de cartón, de papel, que traemos con nosotras que son las fotos de nuestros hijos”: Entrevista a María Herrera Magdaleno, activista en la búsqueda de personas desaparecidas en México
Authors: Gutiérrez Rodríguez Carlos , Nieto María Emilia
Published: October 2020

Entrevista realizada en Buenos Aires el 22 de noviembre de 2018, a María Herrera Magdaleno, madre de personas desaparecidas en México y activista por los derechos humanos, donde presenta las luchas del movimiento de familiares de desaparecidos en México y las labores llevadas adelante por la Cuarta Brigada Nacional de Búsqueda de Personas.
Memoriales modernos: inflexiones en la construcción de la memoria colectiva
Authors: Cardoso Noelia
Published: October 2020

Este artículo aborda los memoriales modernos a partir de las prácticas inapropiadas de algunos de sus visitantes. A través del registro de los modos de uso y promoción de los lugares de memoria y los consiguientes cuestionamientos y debates por parte de los estados, artistas e intelectuales, se propone repensar estos espacios de memoria reciente sus estéticas y las normas que los rigen. De lo que se trata es de desmontar el binomio respeto-falta de respeto entendiendo que las formas no son reaseguro de la comprensión de los sucesos recordados sino un requerimiento que sostienen un orden aparente. Se espera que las presentes reflexiones sean un aporte para fortalecer la memoria colectiva y el rol del arte contribuyendo a los debates sobre la transmisión del pasado y la musealización de la memoria.
Acerca de la imagen de tapa: El Negro Matapacos, por Caiozzama. Noviembre 2019, Santiago de Chile.
Authors: Prácticas artístico-culturales Responsables de la sección
Published: October 2020

Acerca de la imagen de tapa: El Negro Matapacos, por Caiozzama. Noviembre 2019, Santiago de Chile
De la urgencia a la solidaridad. Acciones de visibilidad y apoyo al estallido social en Chile
Authors: Jean Jean Melina
Published: October 2020

“¡No son 30 pesos son 30 años!” fue el nombre seleccionado para la primera intervención de visibilidad y solidaridad con el pueblo de Chile, que tuvo lugar el 1 de noviembre de 2019 en el patio central de la Facultad de Humanidades y Ciencias de la Educación (FaHCE, UNLP). La convocatoria estuvo a cargo de la Maestría en Historia y Memoria, la revista Aletheia, la Prosecretaría de Derechos Humanos (FaHCE), el Programa Interinstitucional de Estudios sobre Memorias, Migraciones, Exilios y Refugios (PIEMMER) y el Equipo de Investigación “Del tercer gobierno peronista a la dictadura de 1976. La eliminación del tiempo bifronte. La ofensiva reaccionaria”. El título de la jornada alude a una consigna muy importante que se viralizó durante las primeras semanas y explica el motivo inicial del estallido que a continuación reponemos para contextualizar la emergencia de nuestras acciones.
Archivo oral de la Comisión Provincial por la Memoria. Memorias encontradas: el archivo y el testigo
Authors: Sahade Julieta , Jaschek Ingrid
Published: October 2020

Esta conferencia formó parte del encuentro “Archivos Sonoros y cultura popular” realizado el 17 de septiembre de 2019 en el marco del Coloquio sobre Memorias Populares organizado por Doctorado en Historia y la Maestría en Historia y Memoria de la FaHCE junto a la presencia del historiador italiano Alessandro Portelli. En dicha conferencia, las autoras presentaron el archivo oral “Memorias encontradas” de la Comisión por la Memoria (CPM). Por un lado, relataron la historia de la producción y recolección de entrevistas surgidas a partir de los distintos trabajos de la CPM y, por el otro, reflexionaron sobre algunas particularidades de la serie “El archivo y el testigo”: el contexto de producción, el diálogo entre el relato oficial/policial y la voz de las y los testigos, los distintos modos de narrar, de contar.
االسم الذي ال ينصرف وطرق تدريسه في مدرسة الخيرات العالية بالو
Authors: Fatimah Titin , Irfan Irfan
Published: October 2020

Tujuan penulisan karya ilmiah ini adalah untuk membahas tentang bagaimana penerapan pengajaran bahasa arab bagi penutur kata selain bangsa Arab sendiri di dalam lingkup madrasah al-Khairat Palu, terkhusus dalam bidang Nahwu dan Shorf seperti tentang bab ism-ism yang tidak dapat berubah harakatnya. Sebagaimana tujuan lainnya dari penulisan karya ilmiah ini adalah mendeteksi masalah-masalah yang muncul selama proses penerapan metode pembelajaran serta mencari solusi terbaik dalam menyelesaikan permasalahan tersebut. Adapun metode penelitian yang digunakan dalam menyusun karya ilmiah ini adalah metode analisis kuantitatif, yaitu proses menemukan pengetahuan dengan menggunakan data sebagai alat analisa keterangan mengenai apa yang ingin diketahui. Dan cara yang dilakukan dalam mengumpulkan data-data ini adalah dengan pengamatan, wawancara, dan dokumen. Adapun hasil dari penelitian ini bahwa proses penerapan yang digunakan dalam pembelajaran tentang bab ism-ism yang tidak dapat berubah harakatnya di madrasah al Khairat Palu adalah dengan menggunakan teori kesatuan yang dikenalkan melalui cara yang lebih banyak bersinggungan dengan kehidupan sehari-hari pada peserta didik.
Gestão estratégica integrada do transporte público de passageiros e suas relações com cidade digital estratégica
Authors: Rezende Denis Alcides , Ramos Ramon Vinicius Ferreira
Published: October 2020

A gestão estratégica integrada é fundamental para o planejamento regional, pois pode oferecer soluções aos problemas comuns aos cidadãos de diversas localidades, como saúde, coleta de lixo e transporte público, bem como a transformação dos municípios em projetos de cidade digital estratégica (CDE) pode auxiliar na coleta de dados, transparência, tomada de decisão e inclusão da população nos processos decisórios. O objetivo é analisar a gestão estratégica integrada do transporte público de passageiros e suas relações com cidade digital estratégica. A metodologia da pesquisa enfatiza a análise qualitativa de documentos que oficializam a rede integrada de transportes (RIT) de Curitiba-PR e disponibilidade livre de acesso aos documentos em questão. Os resultados auferidos evidenciam que de fato os documentos são de livre acesso por meio de portais de informação para a população em geral, porém não há um documento que oficialize as estratégias de desenvolvimento do transporte público de passageiros em um planejamento em longo prazo, como defende o modelo de CDE. A conclusão reitera que a gestão precisa de um modelo efetivo de integração de dados e informações, que permita a transparência e participação popular nos processos decisórios. A pesquisa destaca a importância do debate sobre modelos de gestão adequados, buscando o envolvimento dos cidadãos ativamente na coleta e produção de dados e informações, como o modelo de CDE prevê.
Palavras-chave: Gestão Estratégica. Gestão Integrada. Gestão Urbana. Transporte Público. Cidade Digital Estratégica.
Tipología contractual, vinculación entre contratos y desistimiento: los argumentos de la STJUE, de 12 de marzo de 2020 (asunto C- 583/18)
Authors: Arnau Raventós Lídia
Published: October 2020

The Court denies the term “contracts for passenger transport services” (art. 3,3.k Dir. 2011/83) includes the service contract whose object is to entitle the consumer to a price reduction when passenger transport contract are subsequently concluded. The arguments are: the contract is neither itself directly concerned with enabling the transporting of passengers to be carried out, nor is a contract “inextricably linked” to the transport contract and the exercise of withdrawal will not entail disproportionate consequences to the professional. The comment analyzes the three arguments.
O fim do descanso semanal obrigatório ao sétimo dia?
Authors: Liberal Fernandes Francisco
Published: October 2020

The monologue that is reproduced has in its genesis two sentences related to the imperfect problem of the enjoyment of weekly rest at shift work: the judgments of the Court of Justice of the European Union, of 9-11-2017 (Maio Marques da Rosa, case C - 306/16), and the Supreme Court of Justice, of 14-11-2018 (case 1181/15.4T8MTS.P1.S1). The fact that the issue in question was decided on the basis of rules of general scope (respectively, Article 5, first part, of the Directive 2003/88, concerning certain aspects of the organisation of working time, and Article 232, paragraph 1, of the Labour Code) has given to give these decisions an innovative dimension, potentially disruptive in the social and legal sphere, if it is under-stood that the normativity of the first sentence is directly extendable to the com-mon of labour contracts.
The final conclusion is that the Portuguese labour system enshrines the weekly rest rule on the seventh day, allowing for the possibility of derogations for a limited set of activities; however, in relation to these, the application of this regime depends on provision in terms of collective labour regulation instruments.
A prova resultante de “software de aprendizagem automática”
Authors: Silva Pereira Fernando
Published: October 2020

Machine learning is a field of artificial intelligence that gives computers the ability to learn without being explicitly programmed, posing the problem of using the outputs of deep learning software as evidence in a judicial process. Focusing on Civil Procedure Law, this article aims to reflect on this problem, from the point of view of the admissibility and weight of such an evidence, giving close attention to the north-American experience, where the problem of the use of scientific and technic evidence has been largely discussed.
Thiopental Elevates Steady-State Levels of Intracellular Ca2+ and Zn2+ in Rat Thymic Lymphocytes
Authors: Kamemura Norio , Oyama Keisuke , Ueno Shinya , Mizobuchi Mizuki , Ishidoh Kazumi , Kanematsu Naoki
Published: October 2020

Thiopental is an ultra-short-acting barbiturate and has been used commonly in the induction phase of general anesthesia. However, the toxic effect of thiopental is not completely clear.　The effect of thiopental on intracellular Ca2+ ([Ca2+]i) levels was investigated in non-excitable cells. Experiments were carried out using a flow-cytometric technique, rat thymic lymphocytes (as non-excitable cells), and appropriate fluorescent probes. Treatment of cells with 300 µM thiopental increased Fluo-3 fluorescence intensity, indicating elevation of [Ca2+]i. This increase was partially attenuated by a chelator of intracellular Zn2+. Thus, thiopental elevated both [Ca2+]i and intracellular Zn2+ ([Zn2+]i) levels. Under intracellular Zn2+-free conditions, 100–300 µM thiopental was still able to induce a statistically significant increase in [Ca2+]i, whereas removal of extracellular Ca2+ greatly reduced the increase in [Ca2+]i induced by this dose of thiopental. Therefore, the thiopental-induced increase in [Ca2+]i was mainly due to an increased influx of Ca2+. Treatment of cells with 300 µM thiopental increased FluoZin-3 fluorescence intensity, indicating the presence of [Zn2+]i, both in the presence and absence of extracellular Zn2+. The thiopental-induced elevation of [Zn2+]i was due to an increase in both influx of Zn2+ and intracellular Zn2+ release. Concanavalin A (10 µg/mL) augmented Fluo-3 fluorescence in the presence of an intracellular Zn2+ chelator. The combination of concanavalin A and 100–300 µM thiopental synergistically increased [Ca2+]i. Results suggest that thiopental increases [Ca2+]i in both quiescent and activated lymphocytes, possibly resulting in modulation of immune system function.
Aprendizaje basado en proyectos (ABP) para desarrollar habilidades académicas en la educación superior: una experiencia en Sumapaz
Authors: Cita Triana Nadia Caterine , Sierra Lopez Lizbeth Paola , Ordoñez Ordónez Claudia Lucía , Cepeda-Valencia Juliana
Published: October 2020

La Universidad Nacional de Colombia (UN) ofrece los Programas Especiales de Admisión y Movilidad Académica (PEAMA), para abrir el acceso a la universidad a bachilleres que normalmente no lo tendrían por falta de recursos y bajos puntajes de admisión. En el 2016 se crea el PEAMA Sumapaz, programa que utiliza la metodología de Aprendizaje Basado en Proyectos (ABP). El ABP específico de este programa se propone como objetivo primordial que los estudiantes consoliden habilidades académicas pobremente desarrolladas en la educación básica y media, a la par que avancen en las carreras elegidas con comprensión verdadera de los contenidos de la mayor cantidad de asignaturas que puedan relacionarse con los proyectos auténticos que realizan en Sumapaz. Durante el segundo semestre de 2018 realizamos el proyecto “Conocer a Sumapaz desde una perspectiva ecológica”. Presentamos aquí los resultados preliminares de un estudio cualitativo-narrativo que describe la forma como construimos el proyecto y logramos sus propósitos con profesores y estudiantes participantes en el programa, concentrándonos en el manejo que hicimos del desarrollo de habilidades académicas en los estudiantes. Utilizamos datos provenientes de las reuniones de planeación entre los docentes, así como cortas entrevistas periódicas a los estudiantes sobre cómo fueron entendiendo el proyecto y lo que aprendieron en él. Hacemos así un aporte pedagógico que ilustra cómo el uso en los primeros semestres universitarios de estrategias de enseñanza/aprendizaje centradas en la actividad de los estudiantes, y estimuladoras de conexiones disciplinares y desarrollo de habilidades académicas, puede facilitar la permanencia en la educación superior.