bluuebunny/crossref_metadata_2025 huggingface dataset:
Migration of dental implants in the maxillary sinus – a putative risk of sinus aspergilossis
Authors:   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie, Craiova, Iliescu Alexandru Andrei , Perlea Paula ,   Facultatea de Medicină Dentară, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti, Temelcea Anca Nicoleta ,   Disciplina de Tehnică Dentară, Facultatea de Moaşe şi Asistenţă Medicală, Universitatea de Medicină şi Farmacie „Carol Davila“, Bucureşti
Published: August 2021

Sometimes the maxillary endosseous implants may migrate into the maxillary sinus, a quarter of them being recorded in maxillary sinus bone grafts. Less frequent it occurs after the occlusal loading or during the prosthetic abutment insertion. The displacement and retention of a dental implant in maxillary sinus causes a chronic sinusitis. One of such infection might be aspergillosis. Clinically the aspergillosis of maxillary sinus may be non-invasive, invasive or allergic. The treatment of non-invasive aspergillosis in immunocompetent individuals consists in surgical removal of infected fungal mass without a systemic antifungal medication. The invasive aspergillosis which is affecting immunocompromised persons has to be treated both by surgical and long-term systemic antifungal therapy. In allergic form the surgical removal of nasal polyp and recreation of the patency of the maxillary ostium are recommended.
NON-VARICEAL UPPER GASTROINTESTINAL BLEEDING RECENT GUIDELINES, RISK STRATIFICATION AND PARADIGMS
Authors:   Bucharest University Hospital, El-Khatib Ahed , Alius Catalin ,   Bucharest University Hospital, Serban Dragos ,   Bucharest University Hospital
Published: August 2021

Despite recent advances in the treatment of upper gastrointestinal bleeding (UGI) lesions, mortality and morbidity have remained high. The introduction of scoring systems and novel endoscopic techniques have improved patients outcomes. Although guidelines for managing UGIB have been developed they have not been implemented ubiquitously. The authors offer a point of view in relation to the management of the non variceal UGIB with emphasis on the risk stratification, paradigms that have suffered changes or have been revalidated over the years, newly introduced pharmacological agents and timing of endoscopy.
ETHICAL CONSIDERATION AND PSYCHOSOCIAL CARE FOR PEOPLE WITH HEMOPHILIA
Authors:   Neuroscience Department, “Victor Babes“ University of Medicine and Pharmacy, Timisoara, Hogea Lavinia Maria , Hogea Bogdan Gheorghe ,   Psychologist, Psychotherapist, Aungurence Mihaela ,   Orthopedics and Trauma Department, “Victor Babes“ University of Medicine and Pharmacy, Timisoara, Nussbaum Laura Alexandra ,   Neuroscience Department, “Victor Babes“ University of Medicine and Pharmacy, Timisoara
Published: August 2021

Psychosocial support is an important part of comprehensive care for people with hemophilia. Beyond the medical condition, individuals with hemophilia commonly face a number of psychosocial challenges. Social workers, psychologists and counsellors play a key role in helping new patients and their families adapt and learn to cope with their new reality. It is possible to have hemophilia and still live a full life, even for those who face many social and economic challenges. Medical treatment alone does not automatically translate into better quality of life. Beyond medical treatment, the responsibilities of the hemophilia treatment centre include educating families about how to manage hemophilia and helping them find interventions for psychosocial issues.
PRESENT DATA IN THE DIAGNOSIS AND TREATMENT OF COELIAC DISEASE (2)
Authors:   Spitalul Universitar de Urgenţă, Bucureşti, Olteanu Dan , Diaconescu Alexandru ,   Spitalul Universitar de Urgenţă, Bucureşti, Voiosu Radu ,   Spitalul Clinic Colentina, Bucureşti, Voiosu Andrei ,   Spitalul Clinic Colentina, Bucureşti, Olariu Cristina ,   Institutul Naţional de Boli Infecţioase Matei Balş, Bucureşti
Published: August 2021

Coeliac disease incidence rised during the last 50 years and represents a concern by diagnostic problems and costs. The recent data regarding etiology, pathogeny, comparative diagnostic value of serology and small intestinal biopsy are summarised. The new data about refractory celiac disease to gluten free diet and therapeutic perspectives are also presented (glutenases, larazotide acetate, genetic alteration of cereals, tissulary transglutaminase inhibitors etc).
VARICES (VENOUS DISEASE AGGRAVATING RISK FACTORS EPIDEMIOLOGICAL SURVEY)
Authors:   Centrul Medical „Sf. Spiridon Vechi“, Bucureşti, Muraru Minerva-Rodica
Published: August 2021

Scop. VARICES este un studiu descriptiv transversal efectuat în scopul de a colecta date epidemiologice privind factorii de risc agravanţi şi semnele/simptomele de afectare venoasă la pacienţi aflaţi în stadiile clinice C3-C4 de insuficienţă venoasă cronică (IVC) şi de a radiografia managementul acestor pacienţi în practica specialiştilor de medicină internă din România. Metodă. Screening-ul stadiilor clinice C3-C4 de IVC a fost efectuat prin înrolarea în studiu a pacienţilor consecutivi activi (cu vârsta între 18-65 de ani), care prezentau semne/simptome de IVC stadiile clinice C3-C4 conform clasificării CEAP. Obiectivul principal a fost de a evalua pacienţii din punct de vedere al frecvenţei factorilor de risc agravanţi asociaţi (ortostatism/şezut prelungit, obezitate, istoric familial, fumat, lipsa compresiei elastice, antecedente de tromboză venoasă profundă sau superficială, reflux venos, constipaţie, multiparitate, contracepţie). Obiectivul secundar a fost de a analiza frecvenţa semnelor şi simptomelor de insuficienţă venoasă. Rezultate. Studiul a colectat date de la 151 de pacienţi, în perioada octombrie-noiembrie 2015, prin implicarea a 15 medici specialişti de medicină internă din 10 oraşe mari din România. Stadiile clinice C3-C4 de IVC au fost mai frecvente la femei (68,9%) decât la bărbaţi (31,1%), iar vârsta medie a populaţiei de studiu a fost de 54,85 + 7,95 ani. Factorii de risc agravanţi ai bolii s-au raportat cu următoarea frecvenţă: istoricul familial 74,2%; lipsa aplicării compresiei elastice 68,2%; ortostatismul prelungit 58%; poziţia şezândă prelungită 42%; obezitatea 36,4%; constipaţia 30,5%; fumatul 23,2%. Semnele bolii s-au raportat cu următoarea frecvenţă: venele varicoase 88,7%; edemul 84,7%; telangiectaziile 64,7%; hiperpigmentarea/eczema 42%; lipodermatoscleroza/atrofia albă 4%. Simptomele bolii au apărut cu frecvenţa: senzaţia de picioare grele 88,7%, senzaţia de picioare umflate 80,1%; senzaţia de picioare obosite 76,2%; durere 70,9%; crampe musculare 41,1%; senzaţia de arsuri la picioare 37,1%; furnicături/înţepături 29,1%; senzaţia de picioare neliniştite 23,2%; prurit 20,5%. Concluzie. Studiul VARICES subliniază importanţa screening-ului stadiilor clinice C3-C4 de IVC la pacienţii activi în practica specialiştilor de medicină internă. Se impune continuarea acestui studiu epidemiologic şi extinderea semnificaţiei investigaţiei, cu posibilitatea aplicării tratamentului recomandat pentru această afecţiune de către ghidurile terapeutice actuale, în vederea creşterii aderenţei şi a eficacităţii terapeutice.
DRAWING INSPIRATION FROM THE SPINE, DESIGNING A PEDESTRIAN BRIDGE [SPINE-INSPIRED DESIGN OF A PEDESTRIAN BRIDGE]
Authors: Golkar Nikoo , Sadeghpour Amirhossein , Divandari Javad
Published: August 2021

Natural structures are known to be the source of inspiration for numerous architectural and structural rules in the fields of aesthetics, function, and structure; therefore, the application of the principals governing them could be used for appropriate and optimal design. The present paper was conducted to model the natural structure of load transfer in order to design the structure of a pedestrian bridge with a span of 100 meters. This bridge is located in a mountain park in the tourist area of Kashan, 230 km south of Tehran. For this purpose, by examining the patterns in the nature, which provides a relevant answer to the problem, the spine of animals was identified as the bearing skeleton of the body, the best option for patterning. Inspired by it, a stable structure was designed as a skeleton of a bridge without a middle pillar. Based on a form inspired by the spine of a four-legged animal, the bridge structure was designed. To control the stability of the bridge structure against the loads, the initial design idea was analysed employing the Karamba plugin in Grasshopper software to identify its weaknesses and the final design was obtained. The final design was analysed with SAP2000 structural finite element software to ensure the stability and control of permissible deformations. Additionally, attention to the modular structure of the spine was the source of inspiration for the design of prefabricated elements of the bridge parts, which in addition to reducing the cost of execution, increases the speed of construction of the project. The final design of the pedestrian bridge, which acts similar to a suspension bridge in terms of load transfer and was inspired by the structure of a four-legged vertebrate, is a combination of truss and tensegrity structure and in addition to visual aesthetic, has optimal structural performance.
Inferring the Morphology of Stellar Distribution in TNG50: Twisted and Twisted-stretched Shapes
Authors: Emami Razieh , Hernquist Lars , Alcock Charles , Genel Shy , Bose Sownak , Weinberger Rainer , Vogelsberger Mark , Shen Xuejian , Speagle Joshua S. , Marinacci Federico , Forbes John C. , Torrey Paul
Published: August 2021

We investigate the morphology of the stellar distribution (SD) in a sample of Milky Way–like galaxies in the TNG50 simulation. Using a local in shell iterative method as the main approach, we explicitly show evidence of twisting (in about 52% of halos) and stretching (in 48% of them) in real space. This is matched with the reorientation observed in the eigenvectors of the inertia tensor and gives us a clear picture of having a reoriented SD. We make a comparison between the shape profile of the dark matter (DM) halo and SD and quite remarkably see that their radial profiles are fairly close, especially at small galactocentric radii, where the stellar disk is located. This implies that the DM halo is somewhat aligned with stars in response to the baryonic potential. The level of alignment mostly decreases away from the center. We study the impact of substructures in the orbital circularity parameter. It is demonstrated that in some cases, faraway substructures are counterrotating compared with the central stars and may flip the sign of total angular momentum and thus the orbital circularity parameter. Truncating them above 150 kpc, however, retains the disky structure of the galaxy as per initial selection. Including the impact of substructures in the shape of stars, we explicitly show that their contribution is subdominant. Overlaying our theoretical results on the observational constraints from previous literature, we establish fair agreement.
Spectral Signatures of Population iii and Envelope-stripped Stars in Galaxies at the Epoch of Reionization
Authors: Berzin Elizabeth , Secunda Amy , Cen Renyue , Menegas Alexander , Götberg Ylva
Published: August 2021

While most simulations of the epoch of reionization have focused on single-stellar populations in star-forming dwarf galaxies, products of binary evolution are expected to significantly contribute to emissions of hydrogen-ionizing photons. Among these products are stripped stars (or helium stars), which have their envelopes stripped from interactions with binary companions, leaving an exposed helium core. Previous work has suggested these stripped stars can dominate the Lyman Continuum (LyC) photon output of high-redshift, low-luminosity galaxies post-starburst. Other sources of hard radiation in the early universe include zero-metallicity Population iii stars, which may have similar spectral energy distribution (SED) properties to galaxies with radiation dominated by stripped-star emissions. Here, we use four metrics (the power-law exponent over wavelength intervals 240–500 Å, 600–900 Å, and 1200–2000 Å, and the ratio of total luminosity in FUV wavelengths to LyC wavelengths) to compare the SEDs of simulated galaxies with only single-stellar evolution, galaxies containing stripped stars, and galaxies containing Population iii stars, with four different initial mass functions (IMFs). We find that stripped stars significantly alter SEDs in the LyC range of galaxies at the epoch of reionization. SEDs in galaxies with stripped stars have lower power-law indices in the LyC range and lower FUV to LyC luminosity ratios. These differences in SEDs are present at all considered luminosities (

M

UV

>
−
15

, AB system), and are most pronounced for lower-luminosity galaxies. Intrinsic SEDs as well as those with interstellar medium absorption of galaxies with stripped stars and Population iii stars are found to be distinct for all tested Population iii IMFs.
Measurements of the Magnetic Field Strengths at the Bases of Stellar Coronae Using the Magnetic-field-induced Transition Theory
Authors: Chen Yajie , Liu Xianyu , Tian Hui , Bai Xianyong , Jin Meng , Li Wenxian , Yang Yang , Yang Zihao , Deng Yuanyong
Published: August 2021

Measurements of the magnetic field in the stellar coronae are extremely difficult. Recently, it was proposed that the magnetic-field-induced transition (MIT) of the Fe x 257 Å line can be used to measure the coronal magnetic field of the Sun. We performed forward modeling with a series of global stellar magnetohydrodynamics models to investigate the possibility of extending this method to other late-type stars. We first synthesized the emissions of several Fe x lines for each stellar model, then calculated the magnetic field strengths using the intensity ratios of Fe x 257 Å to several other Fe x lines based on the MIT theory. Finally, we compared the derived field strengths with those in the models, and concluded that this method can be used to measure at least the magnetic field strengths at the coronal bases of stars with a mean surface magnetic flux density about one order of magnitude higher than that of the Sun. Our investigation suggests the need for an extreme ultraviolet spectrometer to perform routine measurements of the stellar coronal magnetic field.
Optimization of amorphous solid dispersion techniques to enhance solubility of febuxostat
Authors: Patel Vaishali P. , Patel Anita P. , Shah Ashish
Published: August 2021

Febuxostat is a selective inhibitor of xanthine oxidase and belongs to BCS class II drugs having low solubility and high permeability. Solubility is the most important parameter which directly affects dissolution, absorption and bioavailability of the drugs. There are different techniques by which we can improve solubility and dissolution rate of poorly soluble drug. Amorphous solid dispersion is one of the methods which can improve solubility as well as powder characteristics. The aim of the present study was to formulate and optimize various methods of formulating solid dispersion by using various drug-to-polymer ratios and identifying the batch which gives higher solubility as well as amorphous powder of the drug febuxostat. Different techniques like hot melt method, solvent evaporation method and spray drying techniques were selected for optimization. Attempts were made to improve solubility of febuxostat by employing Kolliphor P 188, Kolliphor P 237, Eudragit RLPO in different drug-to-polymer ratios (1:1, 1:1.5, 1:2) as carrier. The prepared solid dispersion was characterized for the saturation solubility, percentage yield, using differential scanning calorimetry (DSC), scanning electron microscopy (SEM), powdered X-ray diffraction studies (PXRD), and residual solvent determination. Solid state characterization indicated that febuxostat was present in the amorphous form after mixing with polymeric carrier. In contrast to the pure form of drug, solid dispersion of the drug showed better solubility and amorphous characteristics which can be attributed to decreased crystallinity due to hydrotrophy. Thus, amorphous solid dispersion approach can be used successfully to enhance solubility, dissolution rate and bioavailability of febuxostat.
A new species of Leucostethus (Anura, Dendrobatidae) from Gorgona Island, Colombia
Authors: Grant Taran , Bolívar-García Wilmar
Published: August 2021

We describe a new species ofLeucostethusfrom Gorgona Island, a small (13 km2) island located 35 km from the Pacific coast of southern Colombia. The new species most resemblesL. argyrogasterandL. fugaxfrom western Amazonia at 340–870 m elev. in Peru and Ecuador, with which it shares pale ventral coloration and orange suffusion of the axilla, groin and concealed surfaces of the hind limb, but it is most closely related toL. bilsafrom ca. 340 km SW in the southern Chocó at 420–515 m elev., northwestern Ecuador. We report miniscule white spots on the posteroventral surface of the thighs of the new species and, on the basis of our preliminary assessment of their taxonomic distribution, hypothesize that their presence is a synapomorphy of Dendrobatoidea with subsequent losses in a few groups. Given the apparent restriction of the new species to Gorgona Island, it is Vulnerable according to IUCN Red List criteria. In addition to naming the new species, we also propose the following new combinations:L. alacris(Rivero and Granados-Díaz, 1990)comb. nov.,L. dysprosium(Rivero and Serna, 2000)comb. nov., andL. yaguara(Rivero and Serna, 1991)comb. nov.
Dynamiques de la relation entre corpulence et salaire dans les pays émergents : le cas du Mexique
Authors: Levasseur Pierre
Published: August 2021

Cet article étudie les dynamiques de la relation entre la corpulence et les salaires au Mexique, un pays émergent fortement touché par l’obésité. Dans cette étude empirique, nous utilisons les données de panel issues de l’enquête ménage Mexican Family Life Survey (2002-2012). Premièrement, nous examinons de façon descriptive la relation corpulence-salaire et son évolution dans le temps. Nous appliquons ensuite un modèle par doubles différences fournissant des estimations robustes à l’hétérogénéité invariante dans le temps. Nos résultats montrent que la relation entre la corpulence et les salaires horaires dépend du genre, de l’année d’enquête et du statut professionnel. Tandis que les résultats révèlent des pénalités salariales au cours du temps pour les travailleurs des services en surpoids, nous observons une acceptation relative de l’excès de poids dans d’autres secteurs d’emploi, en particulier dans les emplois à haute qualification. Nos résultats ont ainsi des implications importantes en termes de politiques publiques. Codes JEL: O15, I12, C21.
Le scandale des abus et l’éthique sexuelle de l’Église
Authors: Schockenhoff Eberhard , Feix Marc
Published: August 2021

Engagé sur le chemin synodal de l’Église d’Allemagne avant son décès accidentel, cette intervention en 2019 devant la Conférence épiscopale allemande du théologien Eberhard Schockenhoff sur l’éthique sexuelle catholique est pour ainsi dire un prolégomène de son ouvrage posthume (Eberhard Schockenhoff, Die Kunst zu lieben. Unterwegs zu einer neuen Sexualethik , Fribourg-en-Brisgau, Herder, 2021). Partant des approches scientifiques de l’amour et de la sexualité dans la modernité, il montre à quel point cette vision peut être différente et changeante au fil du temps. En tenant compte des perspectives bibliques et en discutant avec les sciences humaines modernes, il met la morale sexuelle de l’Église catholique à l’épreuve et présente un projet qui correspond au monde actuel des contemporains tout en s’inscrivant dans la tradition de l’Église.
La formation du concept de race à la fin du Moyen Âge : vers une racialisation de la différence religieuse dans les textes ibériques
Authors: Gomez-Bravo Ana M. , Terrien Nicolas
Published: August 2021

Cette étude souligne le rôle essentiel que jouèrent le sang, les pratiques alimentaires, la controverse religieuse sur le baptême et certains marqueurs sensoriels dans la conceptualisation de l’identité des juifs et des conversos dans l’Espagne des xiv e - xv e siècles. Ces thèmes furent élaborés de manière convergente dans les discours médicaux, littéraires, religieux et juridiques, conduisant à un début de racialisation caractérisant les différences religieuses en termes psychobiologiques. Une évolution du champ sémantique du terme raza se produisit en parallèle de ces événements, qui eurent lieu principalement à partir de la fin du xiv e siècle et tout au long du xv e siècle. Cette codification contribua à forger une racialisation de l’identité et de la différence religieuse.
Le terme de race en contexte nobiliaire : une histoire sociale (France, XVI e siècle)
Authors: Haddad Élie
Published: August 2021

Cet article teste la pertinence d’une historicisation radicale du terme de race à partir d’une histoire sociale de ses usages appliqués à la noblesse française du xvi e siècle. La liaison entre race et noblesse, pratiquement absente au début du xvi e siècle, fut avant tout un moyen de mettre l’accent sur une conception patrilignagère des groupes familiaux nobles, et de plus en plus à mesure que l’usage du terme se répandit à partir des années 1560. Cette connotation patrilignagère avait une dimension essentialisante et mettait l’accent sur la filiation plus que sur les fondements matériels, seigneuriaux par exemple, de l’appartenance à la noblesse. Il faut ajouter que le terme de race fut par la suite arrimé à celui de maison qui avait une forte connotation hiérarchique. L’ensemble orienta la conception de la noblesse vers une pensée en termes de catégorie à laquelle appartiennent des personnes, et non en termes de qualité attribuée à des personnes. Dans un contexte où certains nobles revendiquaient une fermeture du second ordre, où la politique royale reprenait et développait la dénonciation des usurpations, où une importance de plus en plus grande était attribuée à l’ancienneté comme critère de distinction nobiliaire, la notion de race vint s’insérer dans un vocabulaire qui structura désormais les débats autour de l’idée de « vraie noblesse », contre des types d’anoblissements, notamment taisibles, désormais qualifiés d’usurpations.
On periodic solutions to a class of delay differential variational inequalities
Authors: Anh Nguyen Thi Van
Published: August 2021

In this paper, we introduce and study a class of delay differential variational inequalities comprising delay differential equations and variational inequalities. We establish a sufficient condition for the existence of periodic solutions to delay differential variational inequalities. Based on some fixed point arguments, in both single-valued and multivalued cases, the solvability of initial value and periodic problems are proved. Furthermore, we study the conditional stability of periodic solutions to this systems.
Detailed tectonic geomorphology of the Dras fault zone, NW Himalaya
Authors: Shah AA ,   Department of Geosciences, Universiti Brunei Darussalam, Brunei, Rajasekharan A , Batmanathan N , Farhan Zainul , Reduan Qibah , Malik JN ,   Southeast Asia Disaster Prevention Research Initiative, Universiti Kebangsaan Malaysia,   Department of Earth Sciences, Indian Institute of Technology Kanpur, India
Published: August 2021

Our recent mapping of the Dras fault zone in the NW Himalaya has answered one of the most anticipated searches in recent times where strike-slip faulting was expected from the geodetic studies. Therefore, the discovery of the fault is a leap towards the understanding of the causes of active faulting in the region, and how the plate tectonic convergence between India and Eurasia is compensated in the interior portions of the Himalayan collision zone, and what does that imply about the overall convergence budget and the associated earthquake hazards. The present work is an extended version of our previous studies on the mapping of the Dras fault zone, and we show details that were either not available or briefly touched. We have used the 30 m shuttle radar topography to map the tectonic geomorphological features that includes the fault scarps, deflected drainage, triangular facets, ridge crests, faulted Quaternary landforms and so on. The results show that oblique strike-slip faulting is active in the suture zone, which suggests that the active crustal deformation is actively compensated in the interior portions of the orogen, and it is not just restricted to the frontal portions. The Dras fault is a major fault that we have interpreted either as a south dipping oblique backthrust or an oblique north dipping normal fault. The fieldwork was conducted in Leh, but it did not reveal any evidence for active faulting, and the fieldwork in the Dras region was not possible because of the politically sensitive nature of border regions where fieldwork is always an uphill task.
Toward a theory of smart media usage: The moderating role of smart media market development
Authors: Gao Biao ,   Jiangxi University of Finance and Economics, Nanchang 330013, China, Huang Lin ,   Graduate School of Business Administration, Kobe University, Kobe 6578501, Japan
Published: August 2021

Smart media usage is influenced by certain critical factors and can be further affected by the degree of diffusion in the market. However, existing research lacks sufficient understanding of the factors affecting smart media usage and their influential mechanisms. Taking AI-enabled smart TV in China as the research object, this study (1) develops a base model that includes users' three key gratifications (bi-directional communication, personalization, and co-creation); and (2) takes two sub-dimensions of market development (geographic segment and income segment) as moderators. Using data from 407 valid samples of current users, the partial least squares structural equation modeling analysis suggests that these three key smart gratifications can impact continuance intention with the moderating effect of market development. This study thus contributes to the literature by (1) clarifying the smart media gratification opportunities (smart media users' motivations or needs) for using smart media itself; (2) exploring the impact of the degree of market development on the uses and gratifications of the smart media itself; and (3) combining the uses and gratifications theory, and the diffusion of innovations theory, to complement each other in a model that provides a more complete picture of smart media usage.
Contribution of endothelial cell-derived transcriptomes to the colon cancer based on bioinformatics analysis
Authors: Wang Jie ,   Department of Pharmacy, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China, Uddin Md. Nazim , Akter Rehana , Wu Yun ,   School of Basic Medicine and Clinical Pharmacy, China Pharmaceutical University, Nanjing 211198, China,   Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka 1205, Bangladesh,   Bioinformatics Research Lab, Center for Research Innovation and Development (CRID), Dhaka, Bangladesh,   Department of General Medicine, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, China
Published: August 2021

Colon tumor endothelial cells (CTECs) plays substantial roles to induce immune invasion, angiogenesis and metastasis. Thus, identification of the CTECs-derived transcriptomes could be helpful for colon cancer diagnosis and potential therapy.

Methods

 By analysis of CTECs-derived gene expression profiling dataset, we identified differentially expressed genes (DEGs) between CTECs and colon normal endothelial cells (CNECs). In addition, we identified the significant pathways and protein-protein interaction (PPI) network that was significantly associated with the DEGs. Furthermore, we identified hub genes whose expression was significantly associated with prognosis and immune cell infiltrations in colon cancer. Finally, we identified the significant correlations between the prognostic hub genes and immune-inhibitory markers in colon cancer.

Results

We identified 362 DEGs in CTECs relative to the CNECs, including117 up-regulated genes and 245 down-regulated genes in the CTECs. In addition, we identified significantly up-regulated pathways in CTECs that were mainly involved in cancer and immune regulation. Furthermore, we identified hub genes (such as SPARC, COL1A1, COL1A2 and IGFBP3) that are associated with prognosis and immune cells infiltrations in colon cancer. Interestingly, we found that prognosis-associated hub genes (SPARC, COL1A1, COL1A2 and IGFBP3) are positively correlated with immune-inhibitory markers of various immunosuppressive cells, including TAM, M2 macrophage, Tregs and T cell exhaustion. Finally, our findings revealed that prognosis-associated upregulated hub genes are positively correlated with immune checkpoint markers, including PD-L1 and PD-L2 and the immunosuppressive markers including TGFB1 and TGFBR1.

Conclusions

The identification of CTECs-specific transcriptomes may provide crucial insights into the colon tumor microenvironment that mediates the development of colon cancer.
Assessment of knowledge of COVID-19 among health care workers-a questionnaire-based cross-sectional study in a tertiary care hospital of India
Authors: Singh Sukhbir ,   Associate Professor, Department of Hospital Administration, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India, Govindagoudar Manjunath B , Chaudhry Dhruva , Singh Pawan Kumar , Vashist Madan Gopal ,   Assistant Professor, Department of Pulmonary & Critical Care Medicine, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India,   Sr. Professor and Head, Department of Pulmonary & Critical Care Medicine, Pt. B. D. Sharma PGIMS, Rohtak, Haryana, India,   Senior Professor and Unit Head, General Surgery, Pt. B. D. Sharma PGIMS, Rohtak, India
Published: August 2021

Background

Health Care Workers (HCW) are among the primary stakeholders and front liners in the fight against COVID-19. They are in direct contact with the patients as primary caregivers and, therefore, are at a higher risk of infection. This Pandemic offers a unique opportunity to explore the level of knowledge among ground-level HCWs during this global health crisis.

Objective

We conducted this study to assess the knowledge and awareness among HCW regarding the COVID-19 Pandemic in a tertiary care hospital.

Methods

It was a cross-sectional study done on HCW comprising faculty, senior residents, junior residents, demonstrators, and nursing staff of various specialties directly involved in the care of suspected/confirmed COVID-19 patients. A pretested questionnaire consisting of 20 questions was used as a study tool and was circulated through the digital platform.

Results

There were a total of 437 respondents. In the subgroup analysis, the respondents in the age group of 55–64 years had a higher mean knowledge score, followed by the respondents in the age group of 18–24 years. For years of experience, the mean knowledge score varied from 13.89 (10–20 years of experience) to 13.83 (5–10 years of experience). The mean knowledge score was the highest for consultants (14.10), followed by Resident Doctors (13.96).

Conclusions

This study has shed some critical clues for further research and interventions. Firstly, as health care workers are probably learning about COVID-19 from their practical exposure rather than formal teaching, it is pertinent to address this issue through well-planned formal sessions of training workshops and lectures.
Les mers sont différentes ou l’imaginaire maritime de Pierre Ier à l’épreuve des ports européens, 1717
Authors: Gouzévitch Dmitri
Published: August 2021

Dans cet article, nous allons examiner les diverses expériences maritimes de Pierre Ier et leur impact sur l’aménagement des ports dans le golfe de Finlande. Une attention particulière sera prêtée à cet égard au deuxième grand voyage du tsar à l’étranger (1716-1717), durant lequel il a visité plusieurs pays du nord-ouest européen et la France. L’analyse de ses impressions portuaires tout au long des côtes de la Baltique, de la mer du Nord et de La Manche, a permis de mettre à plat certaines idées reçues concernant les visées de ce voyage et de conclure que ces impressions ont contribué à concrétiser sa vision de la Baltique comme « mer imaginaire », en en faisant, techniquement, commercialement et politiquement, « le fait maritime » russe.
Materiality of marine sciences in late Imperial Russia and early Soviet Union: Research vessels, instruments, laboratory practices
Authors: Lajus Julia
Published: August 2021

The paper discusses the materiality of marine science in Russia from the example of the Barents Sea. This sea became a scientific frontier in the late nineteenth century and in the first decades of the twentieth century by being included into the international research programme of the International Council for the Exploration of the Sea. The advantage of Russia was the possibility to get the very first Europe research vessel. The legacy of this period lasted into early Soviet time, when oceanography also developed around a research vessel that became a core of the Floating Maritime Institute. The study of the materiality of research is enriched by a focus on gender in marine science.
Être dessinateur ou dessinatrice à la Society of Arts de Londres au xviiie siècle : quels apprentissages ?
Authors: Giardinetti Marina
Published: August 2021

Les archives de la Society of Arts de Londres révèlent que la pratique du dessin technique à but ornemental dans la deuxième partie du xviiie siècle est mixte. Des filles et des garçons participent aux concours organisés par l’institution et remportent des prix pour leurs réalisations. Le dessin n’est pas encore maîtrisé par tous et les esquisses conservées sont les témoins d’une technique en cours d’apprentissage. Il est possible d’appréhender la pédagogie de cet enseignement à travers les manuels de dessin en circulation. La pratique féminine et masculine du dessin et leurs enseignements sont différenciés et reflètent des aspirations artistiques et techniques souvent divergentes. Néanmoins, certains modèles utilisés sont mixtes et leurs copies sont pour les dessinateurs et dessinatrices le moyen de s’entraîner au geste technique tout en s’inspirant de motifs à la mode.
Shipmasters, customs, merchants and the Russian coastal experience in the Baltic ports of the 18th century
Authors: Demchenko Pavel
Published: August 2021

This article explores the specifics of commercial shipping in the Russian Empire’s ports. Actors involved in commercial activities in ports are considered in the perspective of maritime experience. Custom officers, shipmasters and merchants all participated to the commercial activities and coastal experiences of the ports of the Russian Empire. The article traces the impact of spatial specifics on commercial and maritime practices in different ports of the Russian Empire, such as Saint-Petersburg, Riga, Vyborg and Narva. Because of spatial and legal aspects, imperial control of, as well as knowledge about, these ports differed significantly from one to another.
La règle et le temps sur Le Chevalier au lion de Chrétien de Troyes
Authors: Mosset Yannick
Published: August 2021

Flanqué de son lion, le chevalier Yvain parcourt les terres bretonnes pour conquérir et reconquérir la femme qu’il aime. Son parcours aventureux res­semble à un grand jeu dûment réglé et chronométré : il ne cesse de recevoir des échéances et de devoir obéir aux règles des rituels et des lois qui régissent l’univers arthurien. Cet apprentissage des codes et du temps semble fructueux : Yvain finira par respecter ses délais et, surtout, par intégrer les règles de la che­valerie : politesse courtoise, justice dans les armes, compassion pour les faibles, loyauté en amour.
Le lion qui accompagne le héros devient alors son emblème: quelle meilleure incarnation de la noblesse que le roi des animaux ? Et pourtant, le lion est aussi une bête sanguinaire. Chrétien, faisant miroiter le symbole, nous rappelle son ambiguïté. Le lion impose sa force, tout comme les règles du jeu social ne tirent leur justification que parce quelles s’imposent elles-mêmes. On peut alors s’interroger sur le droit qui guide les actions d’Yvain : est-ce celui du plus juste, ou du plus fort ?
Protective Systems Ensuring Durability of Wooden Structures
Authors: Kuklík Petr , Svora Petr , Gregorová Anna
Published: August 2021

Wood is a versatile material able to be used in a wide variety of situations and applications. Wood has also very good strength to weight ratio. Problem is degradation of wood due to bad external conditions. The protection of wood takes many forms including proper design detailing. The majority are directed towards the prevention of moisture access and weathering. However, there are also some design details that can also assist in reducing the risk of biological attack. Our work provides a background on a number of important subjects related to good performance of wooden structures. This paper deals with durability of wood, design for durability of wooden structures, surface modification of wood and also evaluation and monitoring of wooden structures.
Verification of the Use of a Kučera Drill for Testing of Wood Properties
Authors: Černý Pavel , Halamová Romana , Heřmánková Věra
Published: August 2021

In common practice, we encounter cases where it is not possible to test the wood quality by destructive methods and it is, therefore, necessary to use non-destructive or semi-destructive methods, especially when the wood is already used in construction. The article deals with the methodology of non-destructive and semi-destructive testing of wooden structures using the methodology commonly used for the diagnosis of masonry structures, where mortar strength is tested using a so-called Kučera drill, and with verification of the applicability of this method in the testing of wood properties. Kučera drill was specially modified for the purpose of the experiment and its functionality was tested. The depth of penetration of the drill into the test specimen was tested. The article describes the principle of measurement and the design of the initial experiment, but also the pitfalls, which had to be faced.
Properties of Bonding Sealants in the Sealing of Cement-Based Materials
Authors: Boháček Adam , Šlanhof Jiří
Published: August 2021

This paper describes the issue of sealing cement-based materials. These materials can also include concrete elements or cement fiber boards. For the purposes of this work, a cement fiber material is selected, namely glass. This material has good effects in terms of small dust particles on the surface, which damage the bonding sealant and the substrate. Focus on its suitability for sealing cement-based substrates. The method for determining the properties of the sealant and the properties of the stylistic joint between the sealant and the base material is the tensile test. For the purpose of this test, one representative of neutral silicones, one representative of acetate silicones and one representative for acrylic sealants shall be selected. From the results of the tensile test, it is clear that with a suitable choice of the combination of bonding sealant and primer, it is possible to seal such a problematic substrate with good results.
Benefit of Ultra-High Strength Infill in Concrete-Filled Steel Tubular Columns
Authors: Bukovská Pavla , Karmazínová Marcela , Štrba Michal
Published: August 2021

Concrete filled steel tubes (CFST) represent a composite building member suitable especially for the construction of columns of a skeleton frame. Filling the steel tube with concrete allows the use of suitable properties of both materials and their interaction. This is very beneficial in a fire exposure, where a circular column has slightly better fire resistance than a square column. In case of an assessment of columns at the ultimate limit state (ULS), a buckling resistance decides. In previous research, it was found that increasing the strength of concrete increases buckling resistance only to a certain extent. The main aim of the article is to show through a theoretical study what benefit the use of ultra-high strength concrete has for buckling resistance of CFST.
Effect of Nanoparticle Phosphate Rock and Phosphate Solubilizing Fungi on Soil P-Potential, P-Retention, Organic Carbon and Base Saturation on Cilembu’s Inceptisols
Authors: Solihin Muhammad Amir , Suryatmana Pujawati , Nurhakim Fajri Syahid , Devnita Rina , Arifin Mahfud
Published: August 2021

Intensive agricultural cultivation on Cilembu’s Inceptisols has become several soil properties problem for crop production. Nanoparticle phosphate rock and phosphate solubilizing fungi have ability to increase some soil properties content. The research aimed to observe the effect of nanoparticle phosphate rock and phosphate solubilizing fungi on soil P-potential, P-retention, C-organic and base saturation on Cilembu’s Inceptisols. The experiment arranged in Completely Randomized Design. The nanoparticle phosphate rock consisted of 4 levels. The phosphate solubilizing fungi consisted of 2 levels, and 2 replication. Soil P-Potential, P-Retention, C-organic, and Base Saturation were observed. The factors was observed after one month incubation on soil. Results showed that there were an interaction between nanoparticle phosphate rock and phosphate solubilizing fungi on the C-organic after one month incubation. Nanoparticle phosphate rock had affected on C-organic, P-potential and base saturation significantly, but had not affected on P-retention. Utilization of phosphate solubilizing fungi as soil ameliorant had affected significantly on P-potential and C-organic, but had not affected on P-retention and base saturation. Nanoparticle phosphate rock with a dose of 6% had the best effect on increase P-potential and base saturation
Antimicrobial Activity of Calcium Hydroxide Synthesized from Indonesian Limestone against Enterococcus faecalis
Authors: Zakaria Myrna Nurlatifah , Siti Halimah Ida Rodiyah , Sidiqa Atia Nurul , Artilia Ira , Cahyanto Arief
Published: August 2021

Recurrent endodontic infections of treated teeth are mainly linked to microbial persistency in the root canal system. Enterococcus faecalis is a bacterium that is often identified in these recurrent infections. Calcium hydroxide (Ca(OH)2) is a widely used root canal medicament and is now being developed to be produced from natural materials. Ca(OH)2, which is synthesized from natural limestone from Palimanan, Indonesia, has a structure similar to Ca(OH)2, which is often used as a root canal medicament. The purpose of this study was to determine the antimicrobial property of Ca(OH)2 paste synthesized from natural limestone compared to conventional Ca(OH)2 paste. This study is an in vitro experimental study consists of 3 groups (n=24, namely, conventional Ca(OH)2 paste, limestone synthesized Ca(OH)2 paste, and saline as the negative control, for 2 intervals of time and evaluated by Total Plate Counting (TPC) method. Samples were mandibular first premolar root canal prepared by root canal preparation and contaminated with E. faecalis (ATCC 29212). The infected root canals of each group were treated by the medicaments, and samples from the root canals were taken on day 7 (n=4) and 14 (n=4). Results showed that both Ca(OH)2 groups had antimicrobial activities against E. faecalis. The limestone Ca(OH)2 paste group had the least amount of bacterial colonies on the 7th day compared to other groups. In contrast, on the 14th day, the conventional Ca(OH)2 paste had the least bacterial colonies. It can be concluded that the Ca(OH)2 paste synthesized from natural limestone has an antimicrobial effect on E. faecalis, the antimicrobial effect was higher on the 7th day but decreases on the 14th day, whereas the conventional Ca(OH)2 had a higher antimicrobial effect on day 14 compared to day 7. Further studies are expected to improve the long-term antimicrobial effectiveness and sustainability of the natural limestone synthesized Ca(OH)2 paste.
The Effect of Lauric Acid Addition on Characteristics of Biocomposite Edible Film
Authors: Rochima Emma , Nafisah Nur Silmi , Rosidah Rosidah , Rostini Iis , Subaryono Subaryono
Published: August 2021

The biocomposites were prepared from chitosan, carragenan and modified tapioca with lauric acid addition. The biocomposite were used as edible film material thus improving the mechanical characteristics. The purpose of this study was to determine the amount of lauric acid addition that produced biocomposites with the best characteristics. This study used experimental method. The different concentration of lauric acid used as the treatment was 0%, 10%, 20%, 30%, 40% from total solid of hydrocolloids materials (w/w). Data were analyzed statistically using the F test (ANOVA test) with confidence level of 95%. The results showed more than 10% addition of lauric acid decreased the value of moisture content, tensile strenght, percent elongation and water vapor transmission but increase thickness, opacity and transparency value. The addition of 10% lauric acid produced biocomposite with the best characteristics according to JIS (Japanese Industrial Standard) which had the moisture content of 42.65%, thickness of 0.047 mm, tensile strength of 13.8 MPa, percent elongation of 29.2%, water vapor transmission rate of 8.5 g/m2/day, opacity 8.9% and transparency 7.5. This research used renewable and biodegradable materials that can be applied to produce edible packaging with the best characteristics and eco-friendly.
The Physicochemical Properties of PVDF/SiO2 Composite Nanofibers for Potential Application of Lithium-Ion Battery Separators
Authors: Putra Oki Ade , Ilham Berlian Muhammad , Widiyandari Hendri
Published: August 2021

Lithium-ion batteries have the main component include a positive electrode, negative electrode, liquid electrolyte, and membrane separator. The separator was used to secure the battery by preventing it from short circuits. In this paper, the separator PVDF/SiO2 (Polyvinylidene fluoride/Silica) nanofiber membrane was synthesized by double jet sprayers electrospinning method on rotating cylinder collector. The SiO2 colloid nanoparticle concentration was varied at 1000, 2500, and 5000 ppm. The effect of the SiO2 nanoparticle addition to the PVDF nanofiber membrane to improve membrane characteristics, including porosity, high temperature stability mechanical, mechanical strength, and battery capacity stability, were systematically investigated. The PVDF/SiO2 results have a fibrous structure with SiO2 adhering to the fibers' surface. The membrane separator's average thickness is 10.2 micrometers. A large amount of SiO2 addition (SiO2 5000 ppm) on the PVDF nanofibers membrane increased porosity, mechanical properties, and stability at a temperature of 150 °C.