bluuebunny/crossref_metadata_2025 huggingface dataset:
Punica granatum L. Extract Shows Cardioprotective Effects Measured by Oxidative Stress Markers and Biomarkers of Heart Failure in an Animal Model of Metabolic Syndrome
Authors: Niewiadomska Joanna , Kasztura Monika , Janus Izabela , Chełmecka Elżbieta , Stygar Dominika Marta , Frydrychowski Piotr , Wojdyło Aneta , Noszczyk-Nowak Agnieszka
Published: May 2023

Metabolic syndrome (MetS) significantly increases the risk of cardiovascular diseases (CVD), a leading cause of death globally. The presented study investigated the cardioprotective role of dietary polyphenols found in pomegranate peels in an animal model of metabolic syndrome. Zucker diabetic fatty rats (ZDF, MetS rats, fa/fa) were supplemented with polyphenol-rich pomegranate peel extract (EPP) at two dosages: 100 mg/kg BW and 200 mg/kg BW. The extract was administered for 8 weeks. The effect of ethanolic peel extract on the concentration of oxidative stress markers (CAT, SOD, MnSOD, GR, GST, GPx, TOS, SH, and MDA), biomarkers of heart failure (cTnI, GAL-3), and alternations in tissue architecture was assessed. The results showed a significant increase in SH concentration mediated via EPP supplementation (p < 0.001). Treatment with a 100 mg/kg BW dosage reduced the TOS level more efficiently than the higher dose. Interestingly, the CAT and GST activities were relevantly higher in the MetS 100 group (p < 0.001) compared to the MetS control. The rats administered EPP at a dose of 200 mg/kg BW did not follow a similar trend. No differences in the GR (p = 0.063), SOD (p = 0.455), MnSOD (p = 0.155), and MDA (p = 0.790) concentration were observed after exposure to the pomegranate peel extract. The administration of EPP did not influence the cTnI and GAL-3 levels. Histology analysis of the heart and aorta sections revealed no toxic changes in phenolic-treated rats. The findings of this study prove that the extract from pomegranate peels possesses free radical scavenging properties in the myocardium. The effect on alleviating ventricular remodeling and cardiomyocyte necrosis was not confirmed and requires further investigation.
Thermal Management of Lithium-Ion Batteries Based on Honeycomb-Structured Liquid Cooling and Phase Change Materials
Authors: Yang Tianqi , Su Shenglin , Xin Qianqian , Zeng Juan , Zhang Hengyun , Zeng Xianyou , Xiao Jinsheng
Published: May 2023

Batteries with high energy density are packed into compact groups to solve the range anxiety of new-energy vehicles, which brings greater workload and insecurity, risking thermal runaway in harsh conditions. To improve the battery thermal performance under high ambient temperature and discharge rate, a battery thermal management system (BTMS) based on honeycomb-structured liquid cooling and phase change materials (PCM) is innovatively proposed. In this paper, the thermal characteristics of INR18650/25P battery are studied theoretically and experimentally. Moreover, the influence of structure, material and operating parameters are studied based on verifying the simplified BTMS model. The results show that the counterflow, honeycomb structure of six cooling tubes and fins, 12% expanded graphite mass fraction and 25 mm battery spacing give a better battery thermal performance with high group efficiency. The maximum temperature and temperature difference in the battery in the optimal BTMS are 45.71 °C and 4.4 °C at the 40 °C environment/coolant, as against 30.4 °C and 4.97 °C at the 23.6 °C environment/coolant, respectively. Precooling the coolant can further reduce the maximum battery temperature in high temperature environments, and the precooling temperature difference within 5 °C could meet the uniformity requirements. Furthermore, this study can provide guidance for the design and optimization of BTMS under harsh conditions.
Relationship between Abnormal Placenta and Obstetric Outcomes: A Meta-Analysis
Authors: Matsuzaki Shinya , Ueda Yutaka , Matsuzaki Satoko , Sakaguchi Hitomi , Kakuda Mamoru , Lee Misooja , Takemoto Yuki , Hayashida Harue , Maeda Michihide , Kakubari Reisa , Hisa Tsuyoshi , Mabuchi Seiji , Kamiura Shoji
Published: May 2023

The placenta has several crucial physiological functions that help maintain a normal pregnancy. Although approximately 2–4% of pregnancies are complicated by abnormal placentas, obstetric outcomes remain understudied. This study aimed to determine the outcomes and prevalence of patients with abnormal placentas by conducting a systematic review of 48 studies published between 1974 and 2022. The cumulative prevalence of circumvallate placenta, succenturiate placenta, multilobed placenta, and placenta membranacea were 1.2%, 1.0%, 0.2%, and 0.004%, respectively. Pregnancies with a circumvallate placenta were associated with an increased rate of emergent cesarean delivery, preterm birth (PTB), and placental abruption compared to those without a circumvallate placenta. The succenturiate lobe of the placenta was associated with a higher rate of emergent cesarean delivery, whereas comparative results were observed in terms of PTB, placental abruption, and placenta previa in comparison to those without a succenturiate lobe of the placenta. A comparator study that examined the outcomes of multilobed placentas found that this data is usually unavailable. Patient-level analysis (n = 15) showed high-rates of abortion (40%), placenta accreta spectrum (40%), and a low term delivery rate (13.3%) in women with placenta membranacea. Although the current evidence is insufficient to draw a robust conclusion, abnormal placentas should be recognized as a high-risk factor for adverse outcomes during pregnancy.
A Systematic Study of Anti-Osteosarcoma Mechanism of pH-Sensitive Charge-Conversion Cinnamaldehyde Polymeric Prodrug Micelles In Vitro
Authors: Deng Jiapeng , Wang Qichang , Xu Huihui , Li Guoqing , Liu Su , Chen Yixiao , Yu Fei , Yan Weiqiang , Zeng Hui , Liu Peng
Published: May 2023

Osteosarcoma is an aggressive malignant neoplasm, and it is of great significance to the fabrication and investigation of the anti-tumor mechanism of nanomedicine in the treatment of osteosarcoma. Herein, a cinnamaldehyde polymeric prodrug micelle with pH-sensitive charge-conversion ability (mPEG-b-P(C7-co-CA)) was fabricated, and the anti-osteosarcoma mechanism of mPEG-b-P(C7-co-CA) micelle was investigated. mPEG-b-P(C7-co-CA) micelles were prepared by self-assembly method, and their diameter was 227 nm. mPEG-b-P(C7-co-CA) micelles could regulate the cell cycle and inhibit the proliferation of 143B cells, which was demonstrated by flow cytometry analysis, CCK-8 assay and 5-Ethynyl-2′-deoxyuridine (EdU) staining. The wound-healing assay and transwell assay showed that mPEG-b-P(C7-co-CA) micelles effectively inhibited the migration and invasion of 143B cells. It was proven that mPEG-b-P(C7-co-CA) micelles downregulated the levels of proliferation and apoptosis-related proteins and affected osteosarcoma migration and invasion by inhibiting the epithelial-mesenchymal transition (EMT). In addition, mPEG-b-P(C7-co-CA) micelles can also inhibit the transcriptional activity of the PI3K/Akt signaling pathway. Therefore, these findings provide new evidence for the pharmacological effects of mPEG-b-P(C7-co-CA) micelles.
Conceptualizing Callous-Unemotional Traits in Chinese Preschoolers: Factor Structure and Measurement Invariance
Authors: Zhang Gengli , Zhu Yantong
Published: May 2023

With the increasing use of the Inventory of Callous Unemotional Traits (ICU) to examine callous-unemotional traits, few studies have explicitly tested the most appropriate ICU factor structures and measurement invariance in Chinese children at preschool age. This study was conducted with a large community sample of 2055 Chinese preschoolers (53.6% male, M age = 62.23 months, SD = 9.91) to test the most appropriate model of ICU and the measurement invariance across parent gender, child gender, as well as age. The confirmatory factor model suggested that the two-factor model with 11 items (ICU-11) is the best-fitting model for a Chinese preschool sample, which includes a callousness and an unemotional factor. The results from measurement invariance revealed that the factor structures were invariant across child gender, as well as child age and parental gender. The finding suggested that the ICU-11 may be a useful tool for evaluating CU traits in Chinese preschoolers.
Exergames to Limit Weight Gain and to Fight Sedentarism in Children and Adolescents with Obesity
Authors: Calcaterra Valeria , Vandoni Matteo , Marin Luca , Carnevale Pellino Vittoria , Rossi Virginia , Gatti Alessandro , Patanè Pamela , Cavallo Caterina , Re Fabio , Albanese Ilaria , Silvestri Dario , De Nunzio Alessandro , Zuccotti Gianvincenzo
Published: May 2023

Exergames are defined as digital games that require bodily movements to play, stimulating an active gaming experience to function as a form of physical activity (PA). The players interact with the game through whole-body movements improving energy expenditure. Exergames may be effective in improving physical and psychological aspects of children and adolescents with obesity. In this narrative review, we synthesized the current evidence regarding the role of exergames in modifying body composition and weight and in promoting changes in sedentary behavior to define the benefits of active video games as useful tools for fighting sedentarism and to outline the future directions of exergaming as a supplementation exercise rather than a replacement in educational programs for pediatric obesity. Data from the literature indicate that exergames may offer an interesting impact on childhood obesity and may be considered a potential strategy for controlling weight gain and body composition, promote PA, and decrease time spent on sedentary behavior in children and adolescents with obesity. However, exergame use also has some limits, such as children’s poor self-regulation and poor structuring of exergame use. Therefore, a prudent approach should be maintained, and additional high-quality research is needed to determine if exergames can be effectively used in the treatment of childhood obesity and if new digital media, as a supplementation of exercise rather than a replacement, could be considered to combat sedentary behavior in educational programs for pediatric obesity prevention.
A Case of Psoriatic Disease and Hidradenitis Suppurativa in a Child with Chromosome 17q21.31 Microduplication Syndrome
Authors: Tolino Ersilia , Skroza Nevena , Del Giudice Emanuela , Maddalena Patrizia , Bernardini Nicoletta , Proietti Ilaria , Mambrin Alessandra , Marraffa Federica , Rossi Giovanni , Lubrano Riccardo , Potenza Concetta
Published: May 2023

Psoriatic disease is a chronic, relapsing inflammatory disorder, characterized mostly by cutaneous erythematous scaly plaques sometimes associated with arthritis. Hidradenitis suppurativa (HS) is a chronic relapsing inflammatory disease of the apocrine glands, characterized clinically by painful abscesses, sinus tracts and scars. It typically occurs after puberty, affecting mainly intertriginous areas of the body. There is a strong association between HS and psoriasis since they share the same pathogenic inflammatory pathway. The patient presented: low birthweight, microcephaly, facial dysmorphisms, lumbar hyperlordosis, walking difficulties, global psychomotor developmental delay and learning disabilities. A genetic evaluation revealed a 2.5 Mb de novo microduplication in the 17q21.31 chromosomal region. Dermatological examination revealed HS (Hurley stage II-HS) distributed in the genital area and inguinal folds, psoriatic plaques on the retroauricolar folds, on the elbows bilaterally and on the lateral aspect of the right ankle and psoriatic arthritis. The patient was treated with adalimumab, with a marked improvement of both conditions. To our best knowledge, we report the first case of coexisting Psoriatic Arthritis Disease and Hidradenitis Suppurativa in a child with chromosome 17q21.31 microduplication syndrome. We hypothesize that gene CRHR1 duplication included in the 17q21.31 chromosomal region might be involved in the pathogenesis of both diseases.
“Not Every Advisor Is for Me, but Some Are”: Black Men’s Academic Advising Experiences during COVID-19
Authors: Ford Jesse R. , Matthews Dawn Y. , Woodard Derrick M. , Kepple Cassandra R.
Published: May 2023

Contemporary research indicates that Black American men encounter multiple obstacles in higher education settings. Understanding the complexities of how Black men perceive and make sense of academic environments requires addressing a number of elements that influence their academic success. The purpose of this study is to investigate the academic advising challenges faced in virtual environments by Black men during the COVID-19 pandemic. This qualitative case study provides detailed accounts of ten Black men navigating academic advising practices in a virtual setting at large research one historically white institution using focus groups as a method of data collection. Implications and suggestions for future research highlight the significance of supporting Black men in virtual academic advising spaces to create equitable and sustainable practices.
Effects of Marine Microalgae on the Developmental Growth of the Sea Urchin Larviculture Anthocidaris crassipina
Authors: Chu Yiru , Ding De-Sing , Sun Wei-Ting , Satuito Cyril , Pan Chih-Hung
Published: May 2023

The sea urchin is a very important aquatic economic organism in many countries and has high food value. However, it has recently been heavily fished, and it would be of great importance to the sustainable development of coral reefs to develop large-scale aquaculture of sea urchins. Sea urchins are prone to death during larval development. Therefore, in this study, three kinds of microalgae were used as the initial food for sea urchins to evaluate whether different kinds of microalgae can improve their survival and growth rates. Chaetoceros muelleri (C), Isochrysis galbana tml (I), and Dunaliella salina (D) were fed to A. crassipina at concentrations of 5000, 10,000, 20,000, and 30,000 cell mL−1. A fasted group was used as control (N). The final body length, final body width, final stomach length, rudiment length, survival rate and morphology were measured to evaluate development and growth. The results showed that feeding with C. muelleri resulted in better growth and survival. After 9 days of feeding with C(20,000 cells mL−1), the rudiment length reached 203.33 ± 12.47 µm. The onset of metamorphosis was observed 12 days post-feeding. The survival rate after feeding C was also significantly higher than that after feeding I and D. In summary, when sea urchins are breeding, it is recommended to choose C(20,000 cells mL−1) or C(30,000 cells mL−1) as the initial feed for larvae to increase the growth and survival of sea urchin seedlings.
Fermented Kamut Sprout Extract Decreases Cell Cytotoxicity and Increases the Anti-Oxidant and Anti-Inflammation Effect
Authors: Ki Hosam , Baek Jun-Seok , Hawkes Hye-Jin Kim , Kim Young Soo , Hwang Kwang Yeon
Published: May 2023

Kamut sprouts (KaS) contain several biologically active compounds. In this study, solid-state fermentation using Saccharomyces cerevisiae and Latilactobacillus sakei was used to ferment KaS (fKaS-ex) for 6 days. The fKaS-ex showed a 26.3 mg/g dried weight (dw) and 46.88 mg/g dw of polyphenol and the β-glucan contents, respectively. In the Raw264.7 and HaCaT cell lines, the non-fermented KaS (nfKaS-ex) decreased cell viability from 85.3% to 62.1% at concentrations of 0.63 and 2.5 mg/mL, respectively. Similarly, the fKaS-ex decreased cell viability, but showed more than 100% even at 1.25 and 5.0 mg/mL concentrations, respectively. The anti-inflammatory effect of fKaS-ex also increased. At 600 µg/mL, the fKaS-ex exhibited a significantly higher ability to reduce cytotoxicity by suppressing COX-2 and IL-6 mRNA expressions as well as that for IL-1β mRNA. In summary, fKaS-ex exhibited significantly lower cytotoxicity and increased anti-oxidant and anti-inflammatory properties, indicating that fKaS-ex is beneficial for use in food and other industries.
Phenolic Content, Amino Acids, Volatile Compounds, Antioxidant Capacity, and Their Relationship in Wild Garlic (A. ursinum L.)
Authors: Kovačević Tvrtko Karlo , Major Nikola , Sivec Marta , Horvat Dijana , Krpan Marina , Hruškar Mirjana , Ban Dean , Išić Nina , Goreta Ban Smiljana
Published: May 2023

Allium ursinum L. is a wild relative of garlic, and it is abundant in many antioxidant compounds. Sulfur compounds, primarily cysteine sulfoxides (CSOs), are converted through several reactions into various volatile molecules, which are considered the principal flavor compounds of Alliums. In addition to secondary metabolites, wild garlic is abundant in primary compounds, such as amino acids, which serve not only as building blocks for the health-promoting sulfur compounds but also as antioxidants. The aim of this study was to investigate the link between individual amino acid contents, the total phenolic content, and the profile of volatile compounds as well as their influence on the antioxidant capacity of both the leaves and bulbs of wild garlic populations in Croatia. Both univariate and multivariate methods were used to study the differences in the phytochemical compositions among the wild garlic plant organs and the link between individual compounds and antioxidant capacity. Both the plant organ and location, as well as their interaction, have a significant impact on the content of total phenolic content, amino acids, volatile organic compounds, and the antioxidant capacity of wild garlic.
Development of PCA-MLP Model Based on Visible and Shortwave Near Infrared Spectroscopy for Authenticating Arabica Coffee Origins
Authors: Dharmawan Agus , Masithoh Rudiati Evi , Amanah Hanim Zuhrotul
Published: May 2023

Arabica coffee, one of Indonesia’s economically important coffee commodities, is commonly subject to fraud due to mislabeling and adulteration. In many studies, spectroscopic techniques combined with chemometric methods have been massively employed in classification issues, such as principal component analysis (PCA) and discriminant analyses, compared to machine learning models. In this study, spectroscopy combined with PCA and a machine learning algorithm (artificial neural network, ANN) were developed to verify the authenticity of Arabica coffee collected from four geographical origins in Indonesia, including Temanggung, Toraja, Gayo, and Kintamani. Spectra from pure green coffee were collected from Vis–NIR and SWNIR spectrometers. Several preprocessing techniques were also applied to attain precise information from spectroscopic data. First, PCA compressed spectroscopic information and generated new variables called PCs scores, which would become inputs for the ANN model. The discrimination of Arabica coffee from different origins was conducted with a multilayer perceptron (MLP)-based ANN model. The accuracy attained ranged from 90% to 100% in the internal cross-validation, training, and testing sets. The error in the classification process did not exceed 10%. The generalization ability of the MLP combined with PCA was superior, suitable, and successful for verifying the origin of Arabica coffee.
Effects of Four Different Dietary Fibre Supplements on Weight Loss and Lipid and Glucose Serum Profiles during Energy Restriction in Patients with Traits of Metabolic Syndrome: A Comparative, Randomized, Placebo-Controlled Study
Authors: Jenko Pražnikar Zala , Mohorko Nina , Gmajner Dejan , Kenig Saša , Petelin Ana
Published: May 2023

Obesity and its associated complications require various lifestyle changes and treatment options. Dietary supplements are considered an attractive alternative to traditional therapy, mainly because they are accessible to the general population. The aim of this study was to investigate the additive effects of a combination of energy restriction (ER) and four dietary supplements on changes in the anthropometric and biochemical parameters in 100 overweight or obese participants who were randomly assigned one of the dietary fibre supplements containing different dietary fibres or a placebo for 8 weeks. The results confirmed that fibre supplements plus ER significantly (p < 0.01) reduced the body weight, body mass index (BMI), fat mass, and visceral fat and ameliorated the lipid profile and inflammation at 4 and 8 weeks after the start of the study, while in the placebo group, significant differences in some parameters were observed only after 8 weeks of ER. A fibre supplement containing glucomannan, inulin, psyllium, and apple fibre was the most effective at reducing the BMI, body weight, and CRP (p = 0.018 for BMI and body weight and p = 0.034 for CRP compared to placebo at the end of the intervention). Overall, the results suggest that dietary fibre supplements in combination with ER may have additional effects on weight loss and the metabolic profile. Therefore, taking dietary fibre supplements may be a feasible approach to improve weight and metabolic health in obese and overweight individuals.
A Nomogram Model for Predicting the Polyphenol Content of Pu-Erh Tea
Authors: Zhang Shihao , Yang Chunhua , Sheng Yubo , Liu Xiaohui , Yuan Wenxia , Deng Xiujuan , Li Xinghui , Huang Wei , Zhang Yinsong , Li Lei , Lv Yuan , Wang Yuefei , Wang Baijuan
Published: May 2023

To investigate different contents of pu-erh tea polyphenol affected by abiotic stress, this research determined the contents of tea polyphenol in teas produced by Yuecheng, a Xishuangbanna-based tea producer in Yunnan Province. The study drew a preliminary conclusion that eight factors, namely, altitude, nickel, available cadmium, organic matter, N, P, K, and alkaline hydrolysis nitrogen, had a considerable influence on tea polyphenol content with a combined analysis of specific altitudes and soil composition. The nomogram model constructed with three variables, altitude, organic matter, and P, screened by LASSO regression showed that the AUC of the training group and the validation group were respectively 0.839 and 0.750, and calibration curves were consistent. A visualized prediction system for the content of pu-erh tea polyphenol based on the nomogram model was developed and its accuracy rate, supported by measured data, reached 80.95%. This research explored the change of tea polyphenol content under abiotic stress, laying a solid foundation for further predictions for and studies on the quality of pu-erh tea and providing some theoretical scientific basis.
The Extended Direct Algebraic Method for Extracting Analytical Solitons Solutions to the Cubic Nonlinear Schrödinger Equation Involving Beta Derivatives in Space and Time
Authors: Tasnim Farhana , Akbar Md Ali , Osman Mohamed S.
Published: May 2023

In the field of nonlinear optics, quantum mechanics, condensed matter physics, and wave propagation in rigid and other nonlinear instability phenomena, the nonlinear Schrödinger equation has significant applications. In this study, the soliton solutions of the space-time fractional cubic nonlinear Schrödinger equation with Kerr law nonlinearity are investigated using an extended direct algebraic method. The solutions are found in the form of hyperbolic, trigonometric, and rational functions. Among the established solutions, some exhibit wide spectral and typical characteristics, while others are standard. Various types of well-known solitons, including kink-shape, periodic, V-shape, and singular kink-shape solitons, have been extracted here. To gain insight into the internal formation of these phenomena, the obtained solutions have been depicted in two- and three-dimensional graphs with different parameter values. The obtained solitons can be employed to explain many complicated phenomena associated with this model.
Community Pharmacists’ Experiences and Attitudes towards the Provision of Sexual and Reproductive Health Services: An International Survey
Authors: Navarrete Javiera , Hughes Christine A. , Yuksel Nese , Schindel Theresa J. , Yamamura Shigeo , Terajima Tomoko , Sriboonruang Tatta , Patikorn Chanthawat , Anantachoti Puree
Published: May 2023

Access to comprehensive sexual and reproductive health (SRH) services remains a challenge worldwide. Describing community pharmacists’ SRH services in countries with different scopes of practice will aid in understanding how pharmacists view their roles and how to support them in providing needed services. A cross-sectional web-based survey was administered to pharmacists working in community pharmacies in Japan, Thailand, and Canada. The survey covered 7 SRH categories: pregnancy tests, ovulation tests, contraception, emergency contraception, sexually transmitted and blood-borne infections, maternal and perinatal health, and general sexual health. Descriptive statistics were used to analyze the data. A total of 922 eligible responses were included in the analysis (Japan = 534, Thailand = 85, and Canada = 303). Most Thai and Canadian participants reported dispensing hormonal contraceptives (Thailand = 99%, Canada = 98%) and emergency contraceptive pills (Thailand = 98%, Canada = 97%). Most Japanese participants provided patient education on barrier contraceptives for men (56%) and information on the safety of medications in pregnancy (74%) and breastfeeding (76%). The majority of participants expressed interest in additional training and expanding their roles in SRH. Sharing international experiences can guide challenges faced by the evolution of pharmacists’ practice in SRH. Providing pharmacists support could help their readiness for this role.
Nurses’ Perceptions of Patient Fibromyalgia Illness Experiences after Performing Group-Based Problem-Solving Therapy: A Qualitative Research Study
Authors: Montesó-Curto Pilar , Panisello-Chavarria Maria Luisa , Sarrió-Colás Lidia , Toussaint Loren
Published: May 2023

Fibromyalgia patients experience difficulties in their daily lives that are difficult to identify and recognize due to the stigma associated with the disease. Nurses can help identify them to establish biopsychosocial coping and treatment. The main aim of this study was to explore Spanish nurses’ perceptions of the illness experiences of their fibromyalgia patients. Qualitative content analysis from the etic perspective was used. Eight nurses met in focus groups to report their perceptions of the illness experiences of FM patients after led group-based problem-solving therapy in fibromyalgia patients. Four themes emerged: (1) the presence of a “specific trigger” (stressful event) for FM symptoms; (2) fulfilling expected gender roles; (3) a lack of support from the family; (4) abuse. Nurses recognize the mind–body connection after the impact of stress on patients’ bodies. The expected gender roles interfere with patients’ recovery because they feel frustration and guilt about not being able to fulfil them. Managing emotions and improving communication in fibromyalgia is recommended. Clinicians might also consider issues such as abuse and the absence of social–family support for the comprehensive evaluation and effective management of fibromyalgia.
The Price of Hospital Reshaping: Nasal Myiasis Caused by Flesh Fly (Diptera: Sarcophagidae) in Reallocated COVID-19 Intensive Care Unit
Authors: Dolinaj Vladimir , Grujić Jasmina , Križanović Davor , Potkonjak Aleksandar , Pape Thomas , Banović Pavle
Published: May 2023

Myiasis is a condition characterized by fly larvae infestation, most common in tropical regions, but with a risk of occurring anywhere in the world. Here, we report a case of nasal myiasis caused by a sarcophagid fly in a critically ill COVID-19 patient hospitalized in a reallocated ICU department in Serbia and discuss procedures that could prevent the occurrence of similar incidents in reallocated ICU departments worldwide.
Trends and Outcomes in Lung Transplantation in Patients with and without Idiopathic Pulmonary Fibrosis in Spain during the Period 2016–2020
Authors: López-Muñiz Ballesteros Belén , Lopez-de-Andres Ana , Jimenez-Garcia Rodrigo , Zamorano-Leon Jose J. , Carabantes-Alarcon David , Cuadrado-Corrales Natividad , Del-Barrio Jose L. , Perez-Farinos Napoleon , De Miguel-Díez Javier
Published: May 2023

(1) Background: This paper aims to assess temporal trends (2016–2020) in incidence, patient’s characteristics, complications, length of hospital stay (LOHS) and in-hospital mortality (IHM) among patients with and without idiopathic pulmonary fibrosis (IPF) undergoing lung transplantation (LTx). We also analyse the effect of the COVID-19 pandemic on LTx in these populations. (2) Methods: A retrospective, population-based observational study was conducted using the Spanish National Hospital Discharge Database. Multivariable adjustment was conducted with logistic regression to analyse the IHM. (3) Results: We identified 1777 admissions for LTx during the study period, of which 573 (32.2%) were performed in patients with IPF. The number of hospital admissions for LTx rose from 2016 to 2020, both in patients with and without IPF, but a marked reduction was observed from year 2019 to year 2020. Over time, the proportion of single LTx decreased and bilateral LTx increased significantly in both groups. The incidence of LTx complications increased significantly over time along with the increase in the incidence of IPF. No significant differences in the incidence of complications or in the IHM between patients with and without IPF were found. Suffering any complication of the LTx and pulmonary hypertension were conditions positively associated with IHM in patients with and without IPF. The IHM remained stable from 2016 to 2020 in both study populations and was not affected by the COVID pandemic. (4) Conclusions: Patients with IPF account for almost a third of all lung transplants. The number of LTx increased over time in patients with and without IPF, but a marked reduction was observed from 2019 to 2020. Although the proportion of LTx complications increased significantly over time in both groups, the IHM did not change. IPF was not associated with increased complications or IHM after LTx.
The Perception of Volleyball Student-Athletes: Evaluation of Well-Being, Sport Workload, Players’ Response, and Academic Demands
Authors: Vavassori Roberto , Moreno María Perla , Ureña Espa Aurelio
Published: May 2023

Physical activity has been shown to improve the health and well-being of students, athletes and the general population, especially when it is properly monitored and responses are evaluated. However, data are mostly gathered without considering a valuable element, participants’ perceptions. Therefore, the objective was to know the perception of volleyball student-athletes when using different monitoring and response tools that assess well-being, workloads, responses to workloads, and academic demands. A qualitative study using semi-structured interviews with female volleyball student-athletes (n = 22) was used to know players’ perceptions when using a wellness/well-being questionnaire, session ratings of perceived exertion (sRPE), and countermovement jumps (CMJ), and consider academic demands. Results show that the wellness questionnaire and sRPE increased student-athletes’ awareness of well-being and readiness to perform, improved self-evaluation, self-regulation, and self-demand. However, motivation and overcoming challenges were based on the CMJ. Academic demands affected 82% of student-athletes, altering stress, fatigue, and sleep quality. Nonetheless, sport was seen as an activity that helped with academic commitments. Therefore, the wellness questionnaires and the sRPE facilitated self-awareness and positive dispositions toward self-regulation. Simultaneous intensive academic demands and training can produce mutual positive effects if the variables of physical and mental loads are harmonized in the critical academic and sports periods.
The Experiences of Midwives Who Attend Births by Women with Life-Limiting Fetal Conditions (LLFC): A Phenomenological Research Study
Authors: Tataj-Puzyna Urszula , Heland-Kurzak Krystyna , Sys Dorota , Szlendak Beata , Ryś Maria , Krauze Magdalena , Baranowska Barbara
Published: May 2023

Providing care to a woman after a Life-Limiting Fetal Conditions (LLFC) diagnosis is a difficult experience for midwives. This study’s aim is to describe the experience of midwives assisting in births following an LLFC diagnosis. It is a qualitative study using Interpretative Phenomenological Analysis (IPA). Semi-structured in-depth interviews were conducted with 15 midwives with experience in caring for women giving birth following an LLFC diagnosis. The data was analyzed through coding using the MAXQDA tool. The main theme emerging from the experience of midwives concerned difficulty in interacting with the woman giving birth. The analysis singled out four subthemes containing the most significant issues arising from the experience of midwives in caring for a woman giving birth to a lethally ill child: in relation with the woman giving birth; in relation with the child and the family; in relation with oneself; and in relation with the workplace. Midwives should have access not only to solid knowledge about this question, but also to courses developing skills in dealing with difficult situations, in coping with stress, in expressing compassion and, most importantly, in communicating with women and their families in such difficult circumstances.
Google Trends Analysis Reflecting Internet Users’ Interest in Selected Terms of Sexual and Reproductive Health in Ukraine
Authors: Błajda Joanna , Kucab Anna , Miazga Aldona , Masłowski Maciej , Kopańska Marta , Nowak Anna , Barnaś Edyta
Published: May 2023

Introduction: The war in Ukraine has had adverse impacts on all areas of life, including health-related issues. Limited access to medical care increases the need to look for alternative sources of medical information. Aim: To analyze trends of Internet users’ interest in sexual and reproductive health in Ukraine based on Google Trends. Materials and Methods: The retrospective study was based on the analysis of terms related to sexual and reproductive health searched by Ukrainian Internet users. The tool used was Google Trends. The period from 1 January 2021 to 1 January 2023 was analyzed. The time variability in search growths and peaks was assessed from the perspective of two time intervals (before the war and during the war) using the chi-square test. Results: Significant changes have been demonstrated in the interests of Internet users from Ukraine regarding selected issues of sexual and reproductive health during the ongoing war. Compared to the pre-war period, a marked increase was observed in active searches for terms such as “condoms” (p = 0.0081), “rape” (p = 0.0008), “syphilis” (p = 0.0136), “ovulation” (p = 0.0002) and “pregnancy test” (p = 0.0008). Conclusions: The conducted analysis clearly indicates an increased need for information regarding sexual and reproductive health among Ukrainian citizens during the ongoing armed conflict. The analysis of trends among Internet users interests can be a valuable source of knowledge for decision makers, including human rights organizations, regarding the scope and coordination of activities aimed at protecting the sexual and reproductive health of the inhabitants of Ukraine.
The Relationship between Meaning in Life and the Childhood Family Environment among Emerging Adults
Authors: Dameron Emily , Goeke-Morey Marcie C.
Published: May 2023

This study investigates the impact of the childhood family environment on reported meaning in life among emerging adults (n = 507) at a private, urban, religious university. This study found that participants who reported growing up in an emotionally warm family environment ultimately reported more meaning in life as adults and that this effect was mediated by loneliness. This suggests that people from emotionally cold and rejecting early family environments may struggle with meaning in life as adults because they are lonelier. This research contributes a developmental perspective to understanding meaning in life. The public health implications of these findings are discussed. Future research should consider accounting for the effects of early life experiences on meaning in life.
Dual-Exciting Central Carbon Nanoclusters for the Dual-Channel Detection of Hemin
Authors: Gao Ya-Ting , Chang Shuai , Chen Bin-Bin , Li Da-Wei
Published: May 2023

Constructing optical nanoprobes with superior performance is highly desirable for sensitive and accurate assays. Herein, we develop a facile room-temperature strategy for the fabrication of green emissive carbon nanoclusters (CNCs) with dual-exciting centers for the dual-channel sensing of hemin. The formation of the CNCs is attributed to the crosslinking polymerization of the precursors driven by the Schiff base reaction between ethylenediamine and 2,3-dichloro-5,6-dicyano-1,4-benzoquinone. Most importantly, the proposed CNCs have a unique excitation-independent green emission (518 nm) with two excitation centers at 260 nm (channel 1) and 410 nm (channel 2). The dual-exciting central emission can serve as dual-channel fluorescence (FL) signals for highly sensitive and reliable detection of hemin based on the inner filter effect. Because of the great spectral overlap difference between the absorption spectrum of hemin and the excitation lights of the CNCs in the two channels, hemin has a different quenching effect on FL emission from different channels. The dual-channel signals of the CNCs can detect hemin in the range of 0.075–10 μM (channel 1) and 0.25–10 μM (channel 2), respectively. These findings not only offer new guidance for the facile synthesis of dual-exciting central CNCs but also establish a reliable sensing platform for the analysis of hemin in complex matrixes.
The Role of Bulk Stiffening in Reducing the Critical Temperature of the Metal-to-Hydride Phase Transition and the Hydride Stability: The Case of Zr(MoxFe1−x)2-H2
Authors: Jacob Isaac , Babai Dotan , Bereznitsky Matvey , Shneck Roni Z.
Published: May 2023

This study aims to shed light on the unusual trend in the stabilities of Zr(MoxFe1−x)2, 0 ≤ x ≤ 1, hydrides. Both the rule of reversed stability and the crystal volume criterion correlate with the increased hydride stabilities from x = 0 to x = 0.5, but are in contrast with the destabilization of the end member ZrMo2 hydride. The pressure-composition isotherms of ZrMo2-H2 exhibit very wide solid solubility regions, which may be associated with diminished H–H elastic interaction, uelas. In order to discern this possibility, we measured the elastic moduli of Zr(MoxFe1−x)2, x = 0, 0.5, 1. The shear modulus, G, shows a moderate variation in this composition range, while the bulk modulus, B, increases significantly and monotonically from 148.2 GPa in ZrFe2 to 200.4 GPa in ZrMo2. The H–H elastic interaction is proportional to B and therefore its increase cannot directly account for a decrease in uelas. Therefore, we turn our attention to the volume of the hydrogen atom, vH, which usually varies in a limited range. Two coexisting phases, a Laves cubic (a = 7.826 Å) and a tetragonal (a = 5.603 Å, c = 8.081 Å) hydride phase are identified in ZrMo2H3.5, obtained by cooling to liquid nitrogen temperature at about 50 atm. The volume of the hydrogen atom in these two hydrides is estimated to be 2.2 Å3/(H atom). Some very low vH values, have been reported by other investigators. The low vH values, as well as the one derived in this work, significantly reduce uelas for ZrMo2-H2, and thus reduce the corresponding critical temperature for the metal-to-hydride phase transition, and the heat of hydride formation. We suggest that the bulk stiffening in ZrMo2 confines the corresponding hydride expansion and thus reduces the H-H elastic interaction.
Steroids in Lupus: Enemies or Allies
Authors: Enríquez-Merayo Eugenia , Cuadrado Maria J.
Published: May 2023

Glucocorticoids are the gold standard treatment for reducing immune activation and inflammation in a wide range of inflammatory and systemic autoimmune diseases. Glucocorticoids have potent and fast actions that quickly relieve some symptoms and lower mortality in some life-threatening conditions, but they also have side effects that limit the duration of treatment and the dose used. Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by the involvement of numerous organs and systems and the production of autoantibodies. Most current treatments include the use of corticosteroids and immunosuppressive medications. Glucocorticoids in SLE have been classically used not only to induce remission or treat an acute situation but also as maintenance therapy. During the last decades, new approaches to managing SLE have emerged, but corticosteroids continue to be part of all therapeutic regimes. There is more and more evidence about the side effects related to the use (or abuse) of steroids and their relationship with the accrual damage. In this manuscript, we try to make a critical review of the published literature about the benefit and side effects/damage that can be attributed to the use of glucocorticoids.
Innovative Use of Single-Use Face Mask Fibers for the Production of a Sustainable Cement Mortar
Authors: Avudaiappan Siva , Cendoya Patricio , Arunachalam Krishna Prakash , Maureira-Carsalade Nelson , Canales Cristian , Amran Mugahed , Parra Pablo F.
Published: May 2023

Due to the COVID-19 epidemic, biomedical waste management has overwhelmed both developed and developing nations. It is now a critical issue that has to be addressed with minimal possible adverse impact on the environment. This study introduced a technique of recycling face masks into polypropylene fibers for use in concrete. This proposed recycling process provides complete disinfection of contaminated clinical waste and offers the opportunity to transform the characteristics of an end product. Microfibers manufactured from recycled medical masks were subjected to testing. According to the results, polypropylene is the primary component of this research program. Two batches of concrete were made, one with the inclusion of masks as polypropylene fibers and another that performed as a control mix. The modified mortar was compared to the control mix in split tensile, flexure, compressive strength, and water absorption. Compressive strength was found to be improved by about 17%, and tensile strength to be increased by around 22% when mask fibers were incorporated. This research introduced a novel approach for disposing of waste masks and established the preliminary viability of upcycling trash face masks towards mortar concrete production.
Investigation of Effect of Processing Parameters for Direct Energy Deposition Additive Manufacturing Technologies
Authors: Cho Kyu Taek , Nunez Luis , Shelton John , Sciammarella Federico
Published: May 2023

In order to capitalize on the cost-effectiveness of additive manufacturing (AM), it is critical to understand how to build components with consistency and high quality. Directed energy deposition (DED) is an AM method for creating parts layer by layer through the use of a moving heat source and powder material inserted into the melt pool generated on the substrate. DED, like most AM processes, is highly complex due to the rapid thermal gradients experienced during processing. These thermal gradients are determined by a variety of processing parameters, which include laser power, powder feed rate, travel speed, layer height hatch spacing, etc. A lot of effort has been carried out in the additive manufacturing community to understand what these critical parameters are and how they influence the thermal gradients. Despite all these efforts, AM industries rely on a trial-and-error-based approach to find the right set of parameters to produce a quality part. This is time-consuming and not a cost-effective use of AM technology. The aim of our research is to reduce the amount of experimental data in combination with numerical analysis to optimize this relationship. Physics-based two-dimensional melt-pool modeling and experimental results from an OPTOMEC 850M LENS will be utilized to investigate the effects of processing parameters on melt-pool geometry, and the results from this study will provide key processing guidelines to achieve desirable clad geometry and powder efficiency for the DED method.
Improving Aquaculture Water Quality Using Dual-Input Fuzzy Logic Control for Ammonia Nitrogen Management
Authors: Li Hung-Chih , Yu Ker-Wei , Lien Chang-Hua , Lin Chitsan , Yu Cheng-Ruei , Vaidyanathan Sundarapandian
Published: May 2023

In this paper, a closed-loop control system using dual-input fuzzy logic theory is proposed to improve the water quality of aquaculture. The new closed-loop control system is implemented on a Raspberry-Pi-embedded platform using Python programming. The proposed closed-loop control system integrates an RS485 function, a database transfer module, a simulating variable group function, and a trigger function import to achieve savings in human resources, power, and water consumption. The proposed closed-loop control system is equipped with an ammonia nitrogen sensor and solenoid valves for the water exchange. The experimental results demonstrate that the intelligent controller can rapidly eliminate ammonia nitrogen within the range of 2.0 ppm and maintain robust control in response to changes in ammonia nitrogen excretion from a school of fish. The experimental results provide insights into the relationship between tank capacity, water exchange solenoid valves, and ammonia nitrogen degradation time, which can be used to optimize aquaculture density and improve industrialization. The experimental results demonstrate that the savings for power and water can be achieved above 95%.
Ensemble Hindcasting of Coastal Wave Heights
Authors: Pais Namitha Viona , Ravishanker Nalini , O’Donnell James , Shaffer Ellis
Published: May 2023

Long records of wave parameters are central to the estimation of coastal flooding risk and the causes of coastal erosion. This paper leverages the predictive power of wave height history and correlations with wind speed and direction to build statistical models for time series of wave heights to develop a method to fill data-gaps and extend the record length of coastal wave observations. A threshold regression model is built where the threshold parameter, based on lagged wind speed, explains the nonlinear associations, and the lagged predictors in the model are based on a well-established empirical wind-wave relationship. The predictive model is completed by addressing the residual conditional heteroscedasticity using a GARCH model. This comprehensive model is trained on time series data from 2005 to 2013, using wave height and wind data both observed from a buoy in Long Island Sound. Subsequently, replacing wind data with observations from a nearby coastal station provides a similar level of predictive accuracy. This approach can be used to hindcast wave heights for past decades given only wind information at a coastal station. These hindcasts are used as a representative of the unobserved past to carry out extreme value analysis by fitting Generalized Pareto (GP) distribution in a peaks over threshold (POT) framework. By analyzing longer periods of data, we can obtain reliable return value estimates to help design better coastal protection structures.