bluuebunny/crossref_metadata_2025 huggingface dataset:
Cascading failures and maintenance optimization of urban transportation networks
Authors: Dui Hongyan , Zhang Yulu , Chen Liwei , Wu Shaomin
Published: July 2023

A convenient urban transportation network facilitates a high-quality life and a high-growth economy. Due to cascading failures being a ticklish question triggering continuous road congestion, the maintenance plan is momentous to restore the urban transportation network. Considering fault edges are removed and cars slowly drive out of these edges to ease traffic congestion, a traffic distribution model is proposed to analyze the cascading failures process. To resume the transportation network, this paper proposes a maintenance optimization with minimizing maintenance time. It recovers the cascading failures from two perspectives: the intra-area maintenance model and the inter-area maintenance model. At last, a transportation network of a city in China is regarded as a case study to illuminate the feasibility of the proposed models. The results show that on the premise of dividing traffic areas, it is reasonable to adopt the intra-area maintenance plan for cascading failures. Compared with the intra-area maintenance plan, the inter-area maintenance plan saves more time.
Genocide Project: Una Metodología Interactiva. De la Práctica Artística a la Producción de Conocimiento Aplicado
Authors: Gómez Ballesteros Eduardo , Barban Franceschi Roberta
Published: July 2023

El objetivo del artículo es mostrar la práctica artística implementada en Genocide Project y, de forma específica, describir y entender su proceso de producción y método de trabajo, para que este pueda servir de referencia a otros artistas o estudiantes, y establecer sinergias con sus propios proyectos de arte. Para ello, se analizan dos experiencias expositivas de cara a estudiar la metodología interactiva y los elementos que las conforman. Esta metodología se compone de cuatro fases que se retroalimentan entre sí: identificación, recopilación, producción y exposición. Por otro lado, los elementos que conforman cada evento expositivo serían: la arqueología de gestión, la puesta en escena y la visitor-experience. Como resultado, se produce un conocimiento aplicado basado en la investigación y en una metodología interactiva que crea un diálogo entre el artista, la víctima y el espectador y, de esta forma, sería susceptible de replicarse.
Utility of immunohistochemistry in the diagnosis of bone tumors
Authors: M Sailaja , I Satish Rao
Published: July 2023

Immunohistochemistry (IHC) plays an important role in the diagnosis of some bone tumors, especially in the differential diagnosis of primary from metastatic non-osseous tumors and in the categorization of small-round-blue-cell tumors. Use of two positive and two negative markers is ideal to improve the specificity. Choice of markers depends upon what tumors are logically within differential diagnosis after seeing the morphology, in correlation with clinical and radiological details provided to the pathologist. Our present article reviews immunomarkers used in bone tumors and their diagnostic significance.
Anatomical and radiological evaluation of frontal lobe morphometry in healthy and dementia people and machine learning-based prediction of dementia
Authors: ÖZANDAÇ POLAT Sema , TUNÇ Mahmut , OKSÜZLER Mahmut , ÖZEL Selma Ayşe , ÇOBAN Önder , GÖKER Pınar
Published: July 2023

Purpose: This paper aimed to determine the morphometry of the frontal lobe and central brain region using magnetic resonance imaging in patients having dementia and healthy subjects. Materials and Methods: 243 subjects (121 subjects having dementia; 122 subjects healthy group) aged 60-90 years over for 2 years between January 2018 and 2020 were included in this study. Also, the supervised Machine learning based (ML based) detection of dementia has been studied on this obtained real world data. Results: The gender-related changes of frontal region measurements in dementia and healthy subjects were analyzed and, there were differences of measurements’ mean values in gender. In healthy subjects, significance differences were found in all measurements (except the distance from anterior commissure to posterior commissure and outermost of corpus callosum genu to innermost of corpus callosum genu). The means of the measurements were found higher in males than in females. Conclusions: We believe that the knowledge of our study will provide valuable reference data for our population and will help for a surgeon in planning an operation by considering measurements related to the frontal lobe. In addition, ML based supervised methods that were trained on the collected data for detection of dementia showed that it is required to provide as many attributes and instances as possible to train an accurate estimator. However, if this is not possible, by creating new features based on the hidden patterns between attributes and instances we could increase the success of the estimators up to 96.3% f-score value.
Historia del judaísmo en la época del segundo templo
Authors: Sacchi Paolo
Published: July 2023

El conocimiento de los orígenes del cristianismo supone, necesariamente, el de los temas fundamentales del pensamiento judío, es decir, la evolución de la religión y la espiritualidad de Israel entre los siglos VI a.C. y I d.C., íntimamente relacionada, a su vez, con los acontecimientos fundamentales de la historia de Palestina en ese periodo. Desde esta perspectiva, la "Historia del judaísmo en la época del Segundo Templo" se dirige, en palabras de su autor, a "ilustrar, enmarcar y discutir ciertos aspectos del pensamiento judío precristiano que pueden servir para comprender mejor las primeras posiciones cristianas", integrando para ello los últimos resultados de las investigaciones sobre la literatura bíblica, apócrifa, qumránica y del judaísmo helenista. Para esta edición española el autor, ha reelaborado su versión original del capítulo dedicado a la cultura judía del siglo VI, con especial énfasis en la relevancia del exilio en el surgimiento del judaísmo y, en especial, en la figura de Ezequiel como trasmisor de concepciones cosmológicas babilónicas. En el epílogo, también propio de esta edición, repasa sumariamente el estado actual de la investigación de las cuestiones más candentes. Contraportada.
BORSA İSTANBUL’UN ASİMETRİK DİNAMİĞİNİN KANTİL OTOREGRESYON YAKLAŞIMI İLE İNCELENMESİ
Authors: ÖZDEMİR Müge
Published: July 2023

Bu çalışmada, Borsa İstanbul BİST100 endeksinin asimetrik dinamik sürecini incelemek için normal olmayan süreçler için dirençli çıkarımlar sağlayan kantil otoregresyon yaklaşımına dayalı Koenker-Xiao (2004) kantil birim kök testi ile yeni kanıtlar sunuyoruz. Kantil otoregresyon yaklaşımı, hisse senedi piyasalarını etkileyen farklı büyüklükteki ve işaretteki şokların kalıcılığının ölçülmesine olanak tanır. Bu yaklaşım, endeksin uzun dönem dengesindeki asimetrik dinamiklerin ayarlanmasını yakalayabilir. Bu nedenle, kantil birim kök testleri, en küçük kareler regresyon yöntemine dayanan geleneksel birim kök metodolojilerine kıyasla hisse senedi piyasası dinamiklerine yeni yaklaşımlar katmaktadır. Sonuçlarımız, her frekansta tutarlı olmamakla birlikte, piyasa davranışının sadece ortalamaya dönmediğini, aynı zamanda pozitif ve negatif şoklara farklı bir şekilde asimetrik davranış sergilediğini göstermektedir. Geleneksel birim kök testleriyle karşılaştırıldığında, kantil birim kök testleri Türkiye hisse senedi piyasasının etkin olduğunu desteklemek için daha fazla kanıt sağlar. Ayrıca, şok büyüklüğü ve işaretindeki asimetrik çıkarımlar, hisse senedi piyasalarındaki varlık fiyatlandırması açısından etkinlikten sapmaları tespit etmede yardımcı olduğunu gösteriyoruz.
Use of nasolabial flap for reconstruction of the floor of the mouth defects
Authors:   Division of Head and Neck Surgery, Department of Surgical Oncology, University Hospital for Tumors, Sestre milosrdnice University Hospital Center, Zagreb, Croatia, Doko Sandra , Stubljar Boris , Pastorčić-Grgić Marija
Published: July 2023

After an extensive tumor resection, a defect of the floor of the mouth is a significant reconstructive challenge. The main goal is to preserve the mobility of the tongue, which allows the restauration of mastication, deglutition, and articulation. Today, a standard method for reconstruction of floor of the mouth defects is free microvascular flaps, especially radial forearm free flap. Despite that, a potential problem is the high perioperative risk and high complication rate associated with the patient’s age and comorbidities. Current literature suggests that a local nasolabial flap is a reliable treatment option for reconstruction of this type of defect, with a low complication rate and excellent functional and aesthetic results. The aim of this case presentation is to show the use of a local nasolabial flap for reconstruction of the floor of the mouth and to determine the criteria for this type of reconstruction. We present a patient who underwent resection of a floor of the mouth tumor. Due to the patient’s age, medical condition, and comorbidities, the defect was reconstructed with a local nasolabial flap. There were no postoperative complications. Articulation, mastication, and deglutition were satisfactorily rehabilitated. Follow-up showed no signs of recurrent disease twelve months postoperatively. To conclude, a local nasolabial flap is still an important reconstructive choice for oral cavity defects, especially for elderly patients with multiple comorbidities who have a higher risk of perioperative complications.
Analysis of Fish Consumption Pattern of People in Jombang District, East Java, during Pandemic and Endemic Covid-19
Authors: Rahmawati Rahmawati , Sanjaya Yushinta Aristina , Asih Sri Alam Syah Lihan Candra , Putri Ardita , Putri Rinjani Eko , Ayuningtyas Diella Trisna , Mulyani Dwi
Published: July 2023

Fishery resources are a good source of food for human health. The fisheries sector plays a role in food security, not only as a complement but also plays a role in fulfilling food, nutrition, and protein sources, as well as people's income. Food security is closely related to the continuity of fish supply to meet people's needs. In this study the method used was survey method with the type of research used was descriptive research with a quantitative approach and data collection techniques in this study by conducting a survey using a questionnaire. The low consumption of fish in the community is caused by a lack of public knowledge about information on the nutritional content and benefits of consuming fish. The survey results stated that 89.3% of the respondents already knew the benefits of fish and the remaining 10.7% did not know the benefits of fish. As much as 85.4% of the people of Jombang District, East Java, get fish by buying it themselves at traditional markets with 80.6% liking fresh fish products and 19.4% liking processed fish products. As many as 79.6% of the people of Jombang District, East Java consider the quality of fish before buying fish; 45.6% stated that the ease of obtaining fish was their consideration in buying fish; and 50.5% stated price as their consideration in buying fish. As many as 83.5% of respondents stated that there was no difference in fish consumption patterns before and after the pandemic era. After the pandemic, people's frquency in consuming fish has increased, although not significantly. This is possibly due to the start of a sense of public awareness of the body's nutritional needs after the pandemic era.
Efficacy of bilateral ultrasonography-guided transversus abdominis plane block after laparoscopic sleeve gastrectomy: Prospective, randomized, controlled study
Authors: Alver Selçuk , Umutoglu Tarik , Sümer Ismail , Zengin Senniye Ülgen , Topuz Ufuk , Bakan Mefkür , İdin Kadir , Bozkurt Süleyman , Salihoğlu Ziya
Published: July 2023

Aim: Transversus Abdominis Plan (TAP) block is an interfascial plane block, commonly used as an analgesic technique   in abdominal surgeries. The aim of this study is to investigate the postoperative analgesic efficacy of bilateral ultrasonography (US) guided TAP block in patients scheduled for laparoscopic sleeve gastrectomy.Method: In this randomized prospective study; 48 patients, 18-65 years, ASA I-II, morbidly obese (BMI>35), underwent laparoscopic sleeve gastrectomy were included. The patients randomized into two groups: TAP block Group (group TAP) and Control Group (group C). At the end of the operation, bilateral TAP block were performed to 24 patients in Group TAP with a total 40 ml of local solution. 20 ml of local solution was injected into the trocar incision lines of all patients. Patient-controlled analgesia was administered to all patients at a dose of 5 mg/ml tramadol. Tramadol consumption, visual analogue scores (VAS) and the need of rescue analgesia (paracetamol) of the patients at postoperative first 24th hours were recorded.Results: There is no statistical difference in terms of demographic data. Total tramadol consumption and VAS were significantly higher in the Group C (p<0.01). No complications were found in either group.Conclusions: US-guided TAP block provides effective analgesia in patients underwent laparoscopic sleeve gastrectomy surgery.
Pericapsular nerve group (PENG) block as a sole anesthetic method for malignant soft tissue excision
Authors: Medetoglu Ela Nur , Koksal Veysel , Yilmaz Mehmet Akif , Oral Ahiskalioglu Elif
Published: July 2023

Since its first description by Philippe WH Peng in 2018, the Pericapsular Nerve Group (PENG) block, a novel regional anesthetic procedure, has been gaining in popularity. In order to provide appropriate analgesia, an ultrasound-guided local anesthetic injection around the hip joint is performed.We presented, in this case, the successful management of the PENG block for surgical anesthesia in the excision of a malignant soft tissue tumor in the proximal tibia of a 73-year-old female patient. Adequate sensory and motor blocks were obtained, allowing a 70-minute surgery without using additional analgesics. Postoperative pain scores were low, and the patient was discharged without complications.
Spinal anesthesia in a patient with Darier’s disease: A case report
Authors: Boga Ibrahim , Can Tuba
Published: July 2023

Darier’s Disease (Darier-White Disease, keratosis follicularis) is a rare genodermatosis characterized by keratinisation defects that affects the skin, nails and mucosal membranes; it is autosomal and dominantly inherited. To the best of our knowledge, only one case has been reported regarding spinal anesthesia management in a patient suffering from Darier’s disease—this was during Cesarean section. Here, we describe a case of spinal anesthesia with standard skin preparation for inguinal hernia surgery in a Darier’s patient. Spinal anesthesia is a safe anesthesia choice when administered in lesion-free areas.
Recent Trends in Air Transport Research: A Bibliometric Analysis
Authors: Sallan Jose M , Lordan Oriol
Published: July 2023

A single paragraph of about 200 words maximum. For research articles, abstracts should give a pertinent overview of the work. We strongly encourage authors to use the following style of structured abstracts, but without headings: (1) Background: place the question addressed in a broad context and highlight the purpose of the study; (2) Methods: describe briefly the main methods or treatments applied; (3) Results: summarize the article’s main findings; (4) Conclusions: indicate the main conclusions or interpretations. The abstract should be an objective representation of the article, it must not contain results which are not presented and substantiated in the main text and should not exaggerate the main conclusions.
Economic regional of beef cattle development Ciamis Regency
Authors: Perwitasari Fitri Dian , Putra Ahmad Romadhoni Surya , Suwignyo Bambang , Widiati Rini
Published: July 2023

Objective: 1) To identify priority areas with Ciamis Regency that have comparative and competitive advantages 2) Availability of forages in prime priority areas.

Methods: The material used cattle population data from BPS Ciamis Regency from 2016–2020. Panel data, which combines secondary data and cross-section data, were employed in this study. First, data analysis uses LQ and shift-share analysis, and two, it uses the carrying capacity of forage availability and the carrying capacity index.

Results: Regional economic research results show that six sub-districts provide a comparative and competitive basis for superior commodities, namely Banjarsari, Lakbok, Cijeunjing, Cisaga, Rajadesa, and Baregbeg. These five sub-districts (Cimaragas, Sukadana, Panjalu, Panumbangan, and Sindangkasih) cannot be a base for cattle commodities but can be used as a base for other livestock. The study's findings indicate that forage is available, and the carrying capacity index forage availability has an IDD value of>2 SAFE. The Ciamis Regency has a secure green supply for expanding herds of beef cattle and can even export to other areas.

Conclusions: The local government of Ciamis Regency must consider these six sub-districts an excellent commodity base, comparatively and competitively, with the carrying capacity of forage in safe conditions. The local government of Ciamis Regency must increase the number of livestock populations not only in production but also start opening up potential and conservative land for the development of grass cultivation, for example, by utilizing forest land for grass cultivation.
Inhibition of BAK apoptotic activity by Parkin-mediated ubiquitination
Authors: Liu Zhu , Hou Yuzhu , Dong Xu , Cheng Peng , Chen Yanke , Bian Mingxing , Fang Xueru , Liu Yan , Rao Yuanfang , Cao Shuo , Liu Yanjun , Zhang Shuai
Published: July 2023

BAK permeabilizes mitochondrial outer membrane, resulting in apoptosis. This apoptotic activity of BAK is stimulated by binding prodeath activators and must be tightly controlled, otherwise it leads to cancers or neurodegenerative diseases. The Parkinson's disease-related E3 ubiquitin (Ub) ligase Parkin ubiquitinates BAK and inhibits the apoptotic activity. However, the molecular mechanism of how ubiquitination inhibits BAK remains uncharacterized. Here, we verify the Ub modification at BAK K113 by Parkin, and further resolve the solution structure of K113-ubiquitinated BAK complex. The conjugated Ub subunit employs its classical L8-I44-H68-V70 hydrophobic patch to bind within the canonical hydrophobic groove of BAK. This groove-harbored Ub occludes the binding of prodeath BID activators, impairs BID-triggered BAK activation and membrane permeabilization. Loosing Ub association with BAK allows BID to activate the K113-ubiquitinated BAK. Together with structure and function evidence, our study now provide mechanistic insights into the ubiquitination regulatory modality wherein Parkin targets BAK to fine-tune apoptosis.
Nonlinear complex dynamic system identification based on a novel recurrent neural network
Authors: Saini Kartik , Kumar Narendra , Bhushan Bharat , Kumar Rajesh
Published: July 2023

In this paper, a novel Modified Jordan Recurrent Neural Network (MJRNN) model is presented to identify complex nonlinear dynamical systems. The nonlinear dynamic system identification using artificial neural networks is the most commonly used method in control system engineering, due to their capabilities. The structure of the presented model is an extended version of the original Jordan recurrent neural network model. The parameter update equations are obtained by using the back-propagation optimization algorithm, which is the most frequently used method as a learning approach for the training of the proposed model's parameters. The effectiveness of the suggested neural network is evaluated in comparison to other neural networks model such as Jordan recurrent neural network(JRNN), Elman recurrent neural Network(ERNN), Diagonal recurrent neural network(DRNN), and Feedforward neural network(FFNN) model. The robustness of the proposed model is also tested with parameter variation and disturbance signal. The simulation results have shown that the proposed model performs better than the other neural network models.
Hydrodynamic pursuit by cognitive self-steering microswimmers
Authors: Goh Segun , Winkler Roland , Gompper Gerhard
Published: July 2023

The properties of biological microswimmers are to a large extent determined by fluid-mediated interactions, which govern their propulsion, perception of their surrounding, and the steering of their motion for feeding or in pursuit. Transferring similar functionalities to synthetic microswimmers poses major challenges, and the design of favorable steering and pursuit strategies is fundamental in such an endeavor. Here, we apply a squirmer model to investigate the pursuit of pursuer-target pairs with an implicit sensing mechanism and limited hydrodynamic steering abilities of the pursuer. Two hydrodynamic steering strategies are applied for the pursuer’s propulsion direction by adaptation of its surface flow field, (i) reorientation toward the target with limited maneuverability, and (ii) alignment with the target’s propulsion direction combined with speed adaptation. Depending on the nature of the microswimmer propulsion (puller, pusher) and the velocity-adaptation scheme, stable cooperatively moving states can be achieved, characterized by specific squirmer arrangements and controllable trajectories. Importantly, pursuer and target mutually affect their motion and trajectories.
Effects of three personal resources interventions on employees’ burnout
Authors: Perez-Marques Mariola , Letona-Ibañez Onintze , Amillano Alejandro , Carrasco María , Martínez-Rodríguez Silvia
Published: July 2023

Personal resources are related to positive psychological states that can translate into lower burnout among employees. However, although these personal resources can be promoted through ad hoc interventions, there are few studies that analyze this type of interventions in workers. The aim of this study was to assess the effectiveness of three interventions on personal resources on reducing employees' burnout. To this end, it was hypothesized that a positive psychological capital intervention (PsyCap), a job crafting intervention and a combined intervention would have a positive impact on burnout levels. This research used a quasi-experimental, longitudinal, pretest-posttest design, with repeated measures and a waiting list control group. Study participants (N = 144) were all workers divided into three interventions and a control group. This study showed that personal resources interventions were effective in reducing burnout among employees. The PsyCap intervention and the combined intervention showed the greatest efficacy. Contrary to expectations, the combined intervention did not show significantly greater efficacy than the other two experimental groups. The study concludes with a discussion of its limitations and practical implications for future personal resources intervention studies.
First Step Validation Study for Four Subtypes of Suicidality in Mental Health
Authors: Winter Remco F.P. , Meijer Connie M. , Bos Anne T. , Kool-Goudzwaard Nienke , Enterman John H. , Gemen Manuela , Nuij Chani , Hazewinkel Mirjam C. , Steentjes Danielle , Son Gabrielle E. , Beurs Derek P. , Groot Marieke H.
Published: July 2023

Background
Based on clinical experience, a differentiation model for suicidality consisting of four subtypes of suicidality was developed. 1) perceptual disintegration (PD), 2) primary depressive cognition (PDC), 3) psychosocial "turmoil" (PT) and 4) inadequate communication/coping (IC). A study was carried out to examine the validity of the proposed subtypes in absolute/discrete, gradual way and with a self -developed gradual questionnaire.
Objective
A first step was to examine the model and questionnaire for feasibility, reliability and validity in clinical practice. The “real life”, practical application of the model was examined, as were the resulting suggestions for improvement.
Methods
Discharge letters to general practitioners of 25 cases of anonymized suicidal emergency patients were independently reviewed and coded/classified by three psychiatrists, and three nurses. The SUICIDI-2 questionnaire was created to be able to describe our proposed subtypes of suicidal behaviour and was used in this study to allocate cases to these subtypes. Intraclass Correlation Coefficients (ICC) for absolute/discrete and gradual scores were calculated to examine the model’s validity. The study was approved by an ethical board..
Results
All reviewers were able to assign subtypes, using the SUICIDI-2’s absolute and gradual scores, for all cases. We found an average measure of good reliability for absolute/discrete subtypes. For gradual scores, we found excellent average measures for the subtype PDC, and good for the subtypes PD, PT and IC. The reliability of gradual score for the SUICIDI-2 was relatively lower than an alternative gradual scoring, but had a good ICC value for all subtypes. The formulation for PD and IC was discussed with the reviewers and agreement was found about definitions.
Conclusions
The subtypes are validly delineated. After reviewing the results though, we found the interference of substance use was not consistently assessed by all raters. This was grounds to narrow down the criteria of the questionnaire and describe the model more clearly. The SUICIDI-2 questionnaire will be revised. A follow-up study with more conclusions for validation will looked at in relation to clinical and demographic aspects. It is essential for psychologists and other professionals to be involved in the further development and follow-up of the model and validation.
A fast direct solver for surface-based whole-head modeling of transcranial magnetic stimulation
Authors: Makaroff S. N. , Qi Z. , Rachh M. , Wartman W. A. , Weise K. , Noetscher G. M. , Daneshzand M. , Deng Zhi-De , Greengard L. , Nummenmaa A. R.
Published: July 2023

Background: When modeling transcranial magnetic stimulation (TMS) in the brain, a fast and accurate electric field solver can support interactive neuronavigation tasks as well as comprehensive biophysical modeling.
Objective: We formulate, test, and disseminate a direct (i.e., non-iterative) TMS solver that can accurately determine global TMS fields for any coil type everywhere in a high-resolution MRI-based surface model with ~200,000 or more arbitrarily selected observation points within approximately 5 sec, with the solution time itself of 3 sec.
Method: The solver is based on the boundary element fast multipole method (BEM-FMM), which incorporates the latest mathematical advancement in the theory of fast multipole methods – an FMM-based LU decomposition. This decomposition is specific to the head model and needs to be computed only once per subject. Moreover, the solver offers unlimited spatial numerical resolution.
Results: Despite the fast execution times, the present direct solution is numerically accurate for the default model resolution. In contrast, the widely used brain modeling software SimNIBS employs a first-order finite element method that necessitates additional mesh refinement, resulting in increased computational cost. However, excellent agreement between the two methods is observed for various practical test cases following mesh refinement, including a biophysical modeling task.
Conclusion: The method can be readily applied to a wide range of TMS analyses involving multiple coil positions and orientations, including image-guided neuronavigation. It can even accommodate continuous variations in coil geometry, such as flexible H-type TMS coils. The FMM-LU direct solver is freely available to academic users.
Numerical simulations of dam-break flows of viscoplastic fluids via Shallow Water equations
Authors: Muchiri David , Hewett James N. , Sellier Mathieu , Gonzalez Miguel Moyers , Monnier Jerome
Published: July 2023

This paper presents simulations of channelized dam-break flows of Herschel–Bulkley viscoplastic fluids over complex topographies using the Shallow Water equations (SWEs). Particularly, the study aims at assessing the effects of rheological parameters: power-law index (n), consistency index (K) and yield stress (\tau_{c}), on the flow height and velocity over different topographies. Three practical examples of dam-break flow cases are considered: a dam-break on an inclined flat surface, a dam-break over a non-flat topography, and a dam-break over a wet bed. Effects of the bed slope and depth ratios between upstream and downstream fluid levels, on the flow behaviour are also analyzed. Numerical results are compared with experimental data from the literature, and are found to be in good agreement. Results show that for both dry and wet bed conditions, the fluid front position, the peak height, and mean velocity decrease when any of the three rheological parameters is increased. However, based on parametric sensitivity analysis, the power-law index appears to be the dominant factor in dictating the fluid behaviour. Moreover, increasing the bed slope and/or the depth ratio, the wave frontal position moves further downstream. Furthermore, the presence of an obstacle is observed to cause the formation of an upsurge that moves in the upstream direction; which increases by increasing any of the three rheological parameters. The study is useful for an in-depth understanding of the effects of rheology on catastrophic gravity driven flows of non-Newtonian fluids (like lava or mud flows) for risk assessment and mitigation.
Study corrosion inhibitor for mild steel in 1M HCl by pyrazolone-sulfonamide hybrids: Synthesis, characterization evaluation as corrosion inhibitors
Authors: Ashmawy Ashraf M. , Mostafa M. A. , Kamal Abo-Bakr , Ali Gomaa A. M. , El-Gabya M. S. A.
Published: July 2023

Carbon steel is widely used in the petroleum industry for pipelines, storage tanks, and equipment due to its mechanical properties, and strength. However, challenges such as environmental conditions and corrosive materials can affect its lifespan and require maintenance and repair. This work aimed to prepare pyrazalone-sulfonamide hybrids, and confirmed by mass spectra, FTIR, 1H-NMR, and 13C-NMR.These compounds were examined as mild steel corrosion inhibitors in 1 M HCl solutions at 298–323 K using the gravimetric technique, electrochemical measurement, scanning electronic microscope analysis, and quantum chemical calculations. The values of inhibitory efficiency identified by electrochemical and non-electrochemical techniques exhibit good agreement. At various temperatures and in the 50 to 500 ppm concentration range. During the adsorption process, these substances connect to the Langmuir adsorption isotherm. Some adsorption isotherm and kinetic parameters have been developed and discussed. The metal surface had a thin inhibitory protective layer, according to investigations using energy dispersive X-ray spectroscopy (EDX) and scanning electron microscope (SEM). These findings demonstrated the potential of pyrazolone-sulfonamide as effective organic corrosion inhibitors for Carbon Steel. in aggressive solution.
Unraveling the Unfolded Protein Response Signature: Implications for Tumor Immune Microenvironment Heterogeneity and Clinical Prognosis in Stomach Cancer
Authors: ouyang wenhao , Liu Yajing , Huang Hong , Tan Yujing , Huang Zhenjun , Jia Xueyuan , Yu Yunfang , Yao Herui
Published: July 2023

Background Stomach cancer is a leading cause of cancer-related deaths globally due to its high grade and poor response to treatment. Understanding the molecular network driving the rapid progression of stomach cancer is crucial for improving patient outcomes.Methods This study aimed to investigate the role of unfolded protein response (UPR) related genes in stomach cancer and their potential as prognostic biomarkers. RNA expression data and clinical follow-up information were obtained from the TCGA and GEO databases. An unsupervised clustering algorithm was used to identify UPR genomic subtypes in stomach cancer. Functional enrichment analysis, immune landscape analysis, and chemotherapy benefit prediction were conducted for each subtype. A prognostic model based on UPR-related genes was developed and validated using LASSO-Cox regression, and a multivariate nomogram was created. Key gene expression analyses in pan-cancer and in vitro experiments were performed to further investigate the role of the identified genes in cancer progression.Results A total of 375 stomach cancer patients were included in this study. Analysis of 113 UPR-related genes revealed their close functional correlation and significant enrichment in protein modification, transport, and RNA degradation pathways. Unsupervised clustering identified two molecular subtypes with significant differences in prognosis and gene expression profiles. Immune landscape analysis showed that UPR may influence the composition of the tumor immune microenvironment. Chemotherapy sensitivity analysis indicated that patients in the C2 molecular subtype were more responsive to chemotherapy compared to those in the C1 molecular subtype. A prognostic signature consisting of seven UPR-related genes was constructed and validated, and an independent prognostic nomogram was developed. The gene IGFBP1, which had the highest weight coefficient in the prognostic signature, was found to promote the malignant phenotype of stomach cancer cells, suggesting its potential as a therapeutic target.Conclusion This study identified distinct molecular subtypes in stomach cancer patients and developed a prognostic signature to guide personalized treatment. Targeting IGFBP1, which promotes stomach cancer malignancy, could be a promising therapeutic strategy.
Mendelian randomization investigation of the causal association between circulating cytokines and colorectal cancer
Authors: Yang Zhensong , Zhang Menglai , Zhang Yifei , Tang Yutao , Li Yanbao , Zhang Yue , Jian Mi , Jiang Lixin
Published: July 2023

Objective
To explore the causal relationship between colorectal cancer risk and circulating cytokines and identify potential predictive biomarkers.
Methods
This study employed a bidirectional Mendelian randomization (MR) analysis based on data from genome-wide association (GWAS) studies of colorectal cancer from people of European ancestry. The genetic variants associated with 41 circulating cytokines exposed were selected as instrumental variables for this experiment. For robustness and consistency of findings, we conducted additional sensitivity analyses and reverse Mendelian randomization assessments.
Results
The analysis revealed a strong causal relationship between colorectal cancer occurrence and Vascular Endothelial Growth Factor (VEGF), Macrophage Colony Stimulating Factor (MCSF), Interleukin-12p70 (IL-12p70), Interleukin-13(IL-13), Interleukin-10 levels (IL-10) and Interleukin-7 levels (IL-7) and demonstrated partial consistency. Sensitivity analyses indicated that IL-12p70, IL-7 and VEGF are potential colorectal cancer predictive biomarkers.
Conclusion
This Mendelian randomized study offers valuable insights into the causal relationships between specific circulating cytokines and colorectal cancer risk. The identified cytokines may serve as predictive biomarkers, enabling the development of novel diagnostic, preventive, and therapeutic approaches, but further experimental validation of their potential as diagnostic biomarkers or cancer-related pharmacological targets is necessary.
Optimal blade pitch control for enhanced vertical-axis wind turbine performance
Authors: Mulleners Karen , Fouest Sébastien Le
Published: July 2023

Vertical-axis wind turbines are great candidates to enable wind power extraction in urban and off-shore applications. Currently, concerns around turbine efficiency and structural integrity limit their industrial deployment. Flow control can mitigate these concerns. Here, we experimentally demonstrate the potential of individual blade pitching as a control strategy and explain the flow physics that yields the performance enhancement. We perform automated experiments using a scaled-down turbine model coupled to a genetic algorithm optimiser to identify optimal pitching kinematics at on- and off-design operating conditions. Optimal blade kinematics yields a three-fold power coefficient increase at both operating conditions compared to the non-actuated turbine and a 70% reduction in structure-threatening load fluctuations at off-design conditions.
Based on flow field measurements, we uncover how blade pitching manipulates the flow structures to enhance performance. Our results can aid vertical-axis wind turbines to increase their much-needed contribution to our energy needs.
Drug delivery of Mechlorethamine as anticancer drug by Silicon, Carbon and Aluminum Nitride nanocages
Authors: Mekkey Shereen M. , Al-dolaimy F. , Hussein Abdul-Reda Uday , Younis Shahad Mohammed Dhiaa , Kadhim Abed J. , Kareem Mustafa Wathiq Abdul , Abed Noor Kadhim , Asiri Mohammed , Alkhayyat Safa , Alsalamy Ali Hashiem
Published: July 2023

The adsorption of Mechlorethamine on silicon, carbon and aluminum nitride (Si76, C76 and Al38N38) nanocages are investigated. The effects of V adoption on potential of Si76, C76 and Al38N38 nanocages to delivery the Mechlorethamine are investigated. The adsorption energy, Gibbs free energy, recovery time, orbital gap energy, charge transfer of interactions of Si76, C76, Al38N38, V-Si76, V-C76 and V-Al38N38 nanocages with Mechlorethamine are calculated. Results shown that the Si76 and Al38N38 nanocage has higher potential to Mechlorethamine delivery than C76 nanocage. The V adoption of nanocages can increase the interactions of Si76, C76 and Al38N38 nanocages with Mechlorethamine and their abilities to drug delivery. Finally, results are demonstrated that the V-Si76 and V-Al38N38 are acceptable nanocages to delivery of Mechlorethamine with high performance.
A Visual Positioning Model for UAV’s Patrolling Video Sequence Images Based on DOM Rectification
Authors: Liu Haojie , Fan Wei , Wu Di
Published: July 2023

To solve the problem that existing methods cannot calculate positioning information of UAV’s (unmanned aerial vehicle) patrolling video sequence images accurately and robustly in real time, a visual positioning model is proposed, including a robust block-matching algorithm and a precise polynomial-rectifying algorithm. First, the robust block-matching algorithm is used to obtain the best matching area for UAV’s video sequence image on DOM(Digital Orthophoto Map), a preacquired digital orthophoto map covering the whole UAV’s patrolling region. Second, the precise polynomial-rectifying algorithm is used to calculate accurate rectification parameters of mapping UAV’s video sequence image to the best matching area obtained above, and then real time positioning of UAV’s patrolling video sequence images can be realized. Finally, the above two algorithms are analyzed and verified by three practical experiments, and results indicate that even if spatial resolution, surface specific features, illumination condition and topographic relief are significantly different between DOM and UAV’s patrolling video sequence images, proposed algorithms can still steadily realize positioning of UAV’s patrolling video sequence images with about 2.5m level accuracy in 1 second.
Effect of calcination on physicochemical and biological properties of ion-modified nanohydroxyapatite for bone tissue engineering applications
Authors: Kurzyk Agata , Szwed-Georgiou Aleksandra , Pagacz Joanna , Antosik Agnieszka , Tymowicz-Grzyb Paulina , Gerle Anna , Szterner Piotr , Włodarczyk Marcin , Płociński Przemysław , Urbaniak Mateusz M. , Rudnicka Karolina , Biernat Monika
Published: July 2023

The study examines the effect of calcination at a temperature of 1200°C on the physicochemical and biological properties of nanohydroxyapatite (nanoHAP) substituted with magnesium (Mg2+), strontium (Sr2+), and zinc (Zn2+). The materials were characterized by Fourier-transform spectroscopy, X-ray diffraction (XRD), scanning electron microscopy (SEM), and thermal analysis methods. Moreover, in vitro biological characterization, including cytocompatibility, cell proliferation, osteogenic potential, and reactive oxygen species production, was performed. The XRD results indicate that the ion substitution of nanoHAP has no effect on the apatite structure, and after calcination, β-tricalcium phosphate (β-TCP) is formed as an additional phase. SEM analysis showed that calcination induces the agglomeration of particles and changes in surface morphology. A decrease in the specific surface area and in the ion release rate was observed. Calcination and nanoHAP ion modification are beneficial for cell proliferation and osteoblast response and provide additional stimuli for cell commitment necessary for bone regeneration.
Comparative Analysis of Therapeutic Effect of Plasmolifting on the Ankle and Appendicular Joints
Authors: Teplov Oleg , Salikhov Ramil , Chekunov Mikhail , Galimov Damir , Pankov Igor , Teplov Alexandr
Published: July 2023

The case of joints of the upper and lower appendages is the matter for discussion of differences in mechanisms of therapeutic effect of the plasmolifting (PL). It involves 3–5 time injections of platelet mass extracted from autologous blood into injury area spaced a week apart. The ankle joint subjected to PL therapy, compared against knee, elbow and shoulder joints, shows an extremely low ability for restoration of its functionality. Therapeutic benefit is contributed by ability of biologically active substances (BAS) and cytokines released by platelets (Pl) for activation of metabolic processes within damaged tissues. In turn, it insures restoration of morphofunctional disorders of inflammatory genesis and reparative capabilities. Successive application of PL is directly dependent on the tissues that make up a certain joint. The positive effect of the introduction of Pl auto-suspension is determined by the presence of cytokine donor cells, especially platelet activation factor (PAF). Their sufficient amount triggers Pl granulation. An extensive capillary network results with a saturated blood supply and ensures access of granulocyte cells to the sanitized tissue. Besides, basophils and mast cells of connective tissue together with the endothelium of the above capillaries are also PAF sources. All of the above provides a positive therapeutic effect of the PL method on the knee, elbow and shoulder joints unlike the absence of its practical therapeutic effect on the ankle joint and Achilles tendon.
Concentrations and oxidative potential of fine particulate matter and black carbon inhalation doses at the major US-Mexico Port of Entry San Ysidro/El Chaparral
Authors: Zurita Rita , Quintana Penelope J.E. , Toledano-Magaña Yanis , Wakida Fernando T. , Montoya Lupita D. , Castillo J. E.
Published: July 2023

The San Ysidro/El Chaparral Land Port of Entry (SYPOE), located between San Diego, US and Tijuana, Mexico, is the busiest border crossing in the Western hemisphere, with long waiting times to all users. People crossing, working, or living near the SYPOE are exposed to vehicular pollutants, especially particles with aerodynamic diameters < 2.5 µm (PM2.5) and black carbon (BC), which have been linked to adverse health effects.This study presents the first PM2.5 and BC concentrations measurements made on the Mexican side of the SYPOE (2017 and 2019). The oxidative potential (OP) for PM2.5 and the inhalation dose of BC for various groups at the border were also evaluated. Autumn and winter show the highest PM2.5 concentrations at the SYPOE (mean 28.7 µg m− 3 and 28.2 µg m− 3, respectively). BC concentrations at the SYPOE were the highest in winter 2017 (mean 5.7 ± 6 µg m− 3), showing concentrations 2.3 times higher for periods with low wind speeds, compared to high winds. The highest OPDTT of PM2.5 was present in winter, with a value of 18.5 pmol min− 1 µg− 1 (0.6 nmol min− 1 m− 3). The highest average daily dose for pedestrians in autumn 2018 was 5.9 µg for a 60 min waiting time. For the workers, the highest average daily dose was in winter 2017 (19 µg for an average of a 10-hr work shift). Decreasing waiting times for pedestrians and adjusting work schedules for border workers on high concentrations days would reduce inhalation dose and improve environmental justice at the border.
Effect of bulbospongiosus muscle injection with botulinum-A toxin for treatment of primary premature ejaculation. A preliminary results of randomized controlled trial
Authors: Ghaith Ahmed , Almekaty Khaled , Ragab Maged , Rashed Ayman , Hagras Ayman , Ghoneem Ayman , Raheem Amr Abdel , Zahran Mohamed
Published: July 2023

Background:
Premature ejaculation is a common sexual disorder that significantly impacts the quality of life for both men and their partners. Various treatment options have been explored, including behavioral techniques, selective serotonin reuptake inhibitors (SSRIs), and local anesthetics. However, the outcomes of these treatments have been inconsistent for many patients.
This study aimed to evaluate the effectiveness and safety of injecting botulinum-A toxin into the bulbospongiosus muscle for treating premature ejaculation (PPE) in Egyptian patients.
Materials and methods:
Sixty patients with PPE were randomly assigned prospectively to two groups: one receiving botulinum-A toxin injections and the other receiving saline injections as a placebo. The injection was done under US guidance to localize the site of bulbospongiosus muscle.
Results:
After the follow-up period, 57 patients completed the study. Initially, there were no significant differences between the two groups in terms of age, baseline Intravaginal Ejaculation Latency Time (IELT), Premature Ejaculation Profile (PEP) score, or partner satisfaction.
Throughout the study, there were no statistically significant differences between the two groups in terms of IELT, PEP score, or female partner satisfaction at 1, 3, and 6 months after the intervention. However, the treatment group did show a significant increase in the median PEP score at 1 and 3 months compared to baseline. Unfortunately, no significant change was observed at 6 months, and there was no improvement in IELT or female partner satisfaction at any of the time points.
Conclusion:
While the treatment was found to be safe, this study did not demonstrate significant efficacy of botulinum-A toxin injections into the bulbospongiosus muscle for managing PPE symptoms when compared to a placebo. Further research with larger sample sizes is needed to validate these findings and explore alternative treatment options for PPE.