bluuebunny/crossref_metadata_2025 huggingface dataset:
Toxoplasma gondii seropositivity and cognitive functioning in older adults: The national health and nutrition examination survey 2011 to 2014
Authors: Deng Yu
Published: October 2022

Objective
To examine the relationship between Toxoplasma gondii infection and cognitive functioning in older adults.
Method
A total of 2,956 older adults aged 60 and above from the National Health and Nutrition Examination Survey from 2011 to 2014 were included. Serum toxoplasma gondii antibody was analyzed in the lab. A value > 33 IU/mL was categorized as positive for toxoplasma gondii infection; <27 IU/mL was categorized as negative. Cognitive tests included the Consortium to Establish a Registry for Alzheimer’s Disease Word Learning subtest (CERAD-WL) immediate and delayed memory, the Animal Fluency test (AFT), and the Digit Symbol Substitution Test (DSST). Multivariate linear regression models were constructed to examine the association between toxoplasma gondii seropositivity and standardized cognitive test-specific and global cognition z scores. All models were adjusted for age, race/ethnicity, education, depressive symptoms, smoking status, body mass index, prevalent coronary heart disease, stroke, and systolic blood pressure.
Results
Most of the 2,956 participants (mean age 70.0) were female (51.0%), non-Hispanic White (48.3%), and completed some college or above (48.3%). A total of 703 participants were positive for toxoplasma gondii infection (23.8%). Adjusted linear regression showed that compared with participants with negative toxoplasma gondii infection, those with positive toxoplasma gondii infection had lower CERAD-WL immediate memory (beta [β] -0.16, 95% confidence interval [CI] -0.25,-0.07), CERAD-WL delayed memory (β -0.15, 95% CI -0.24,-0.06), AFT (β -0.15, 95% CI -0.24,-0.06), DSST (β -0.34, 95% CI -0.43,-0.26), and global cognition (β -0.24, 95% CI -0.32,-0.16) z scores after controlling for the covariates.
Conclusions
Toxoplasma gondii seropositivity is independently associated with worse immediate and delayed verbal learning, language proficiency, executive functioning, processing speed, sustained attention, working memory, as well as global cognition in older adults. Public health measures are needed to prevent toxoplasma gondii infection, which may help preserve cognitive functioning in older adults.
Retrospective analysis of Vitamin A levels in children in Shandong, China
Authors: Zhang Xiuqing , Ma Yan , Wang Lijun , Song Bindong
Published: October 2022

Background
Vitamin A (VA) levels of children are essential for health. There is a worldwide concern in VA deficiency(VAD), which is associated with some diseases such as dry eyes, respiratory, digestive and immune system diseases in children.
Objective
The VA levels of children aged 0–14 years who visited our hospital located in Linqing City,Shandong Province, China from February 2019 to January 2020 were screened to provide evidence for prevention and treatment of VAD in children.
Methods
Children aged 0–14 years were selected as the research objects, and VA levels were determined by liquid chromatography, and the effects of gender, age and different seasons on VA levels were analyzed.
Results
A total of 1965 children were investigated, ranging from 0 to 14 years old. Among them, 1191 were boys, accounting for 60.61%. 774 were girls, accounting for 39.39%. The normal range of VA levels is 0.3-0.7mg/L. Based on this range, The highest rates of VAD were found in children within 1 year old. 979 (49.8%) of the VA levels were below normal. 211(10.7%)children were deficient and 768(39.1%) children were subclinical deficient. 164(63.3%)children with RRTI and RTI were deficient.467(43.4%)healthy children were deficient.One person (0.05%) exceeded the normal level value. There was no significant difference in serum VA levels between boys and girls (P > 0.05), indicating that gender difference had no effect on VA levels. However, the influence of different seasons on VA levesl were statistically significant in different age groups (P < 0.05).
Conclusion
Nearly half of the children's VA levels were lower than normal value, which was related to age and season, but not gender. Children with RRTI and RTI had much lower VA levels than healthy children.
Can the physical act of sexual intercourse before frozen embryo transfer improve IVF treatment outcome? A Randomized Clinical Trial
Authors: Hou Jin-wei , Yuan Li-hua , Cao Xian-ling , Song Jing-yan , Sun Zhen-gao
Published: October 2022

Background

Exposure of the female reproductive tract to either seminal plasma or fluid component of the ejaculate is beneficial to achieving successful embryo implantation and normal embryo development. But whether the "physical" component of of sexual intercourse during the peri-transfer period have any influence on FET pregnancy outcome is not clear.

Methods

We conducted a randomized trial that included 223 patients undergoing IVF treatment at a University-affiliated reproductive center from 19 July 2018 to 24 February 2019. Enrolled patients undergoing IVF treatment were randomized either to engage sexual intercourse using the barrier contraception (Group A, n = 116) or to abstain (Group B, n = 107) one night before FET. The follow-up parameters included biochemical losses rate, clinical pregnancy, early abortion and implantation rate.

Results

Patients having intercourse had higher clinical pregnancy rate (51.72% vs. 37.07%, P = 0.045) and implantation rate (38.31% vs. 24.77%, P = 0.005) compared to those did not engage intercourse. However, there was no significant difference of the spontaneous abortion rate between two groups (11.67% 33 vs. 14.63%, P = 0.662).

Conclusions

Sexual intercourse before the day of embryo transfer may improve the clinical pregnancy and implantation rates during the frozen- thawed embryo transfer (FET) cycle. However, it should be noted that patients choose only one time for sexual intercourse, that is, the night before embryo transfer.

TRIAL REGISTRATION NUMBER:

This study was registered at the China Clinical Trial Registration Center, with the registration number ChiCTR1800017209.
Assessing the Risk of Crashes on GCC Roads with a Markov-Based Method
Authors: AlKheder Sharaf , Al-Rashidi Moudi
Published: October 2022

Road traffic accidents represent a serious problem all over the world, causing several losses in many ways. The situation in United Arab Emirates (UAE) is not an exception. Therefore, this paper was developed providing a frequencies analysis for accidents data within five successive years on Abu Dhabi roads. Markov modeling was used to find the transition probability from either the (week, month, or year) to the next level, and the steady state probability was estimated using a long run probability. Two policies were used to reduce the number of accidents. It was concluded that the sojourn time for the first policy was better than the second one. Therefore, for the monthly and yearly transition probability matrix only the first policy was applied. Further research should consider the total vehicle number to find the accident rates and identify the significant reasons of accidents to determine the suitable actions.
Hemostatic Efficacy of a Flowable Collagen-Thrombin Matrix during Coronary Artery Bypass Grafting: A Double-Blind Randomized Controlled Trial
Authors: Kim Hyo-Hyun , Lee Kang Ju , Lee Seung Hyun , Kang Dae Ryong , Lee Jun Hyeok , Youn Young-Nam
Published: October 2022

Background

Flowable hemostatic agents have the advantage of being able to be applied to irregular wound surfaces and difficult to reach areas. We sought to compare the effectiveness and safety of the flowable hemostatic sealants Collastat® (collagen hemostatic matrix, [CHM]) and Floseal® (gelatin hemostatic matrix, [GHM]) during off-pump coronary artery bypass (OPCAB).

Methods

In this prospective, double-blind, randomized controlled trial, 160 patients undergoing elective OPCAB surgery were enrolled between March 2018 and February 2020. After primary suture of the aortocoronary anastomosis, an area of hemorrhage was identified, and patients received either CHM or GHM (n = 80, each). Study endpoints were the following: proportion of successful intraoperative hemostasis and time required for hemostasis overall postoperative bleeding, proportion of transfusion of blood products, and surgical revision for bleeding.

Results

Of the total patients, 23% were female, and the mean age was 63 years (range: 42–81 years). Successful hemostasis proportion within 5 min was achieved for 78 patients (97.5%) in the GHM group, compared to 80 patients (100%) in the CHM group (non-inferiority p = 0.006). Two patients receiving GHM required surgical revision to achieve hemostasis. There were no differences in the mean time required to obtain hemostasis [GHM vs. CHM, mean 1.49 (SD 0.94) vs. 1.3 (0.60) min, p = 0.272], as confirmed by time-to-event analysis (p = 0.605). The two groups had similar amounts of mediastinal drainage for 24 h postoperatively [538.5 (229.1) vs. 494.7 (190.0) ml, p = 0.298]. The CHM group required less packed red blood cells, fresh frozen plasma, and platelets for transfusion than the GHM group (0.5 vs. 0.7 units per patient, p = 0.047; 17.5% vs. 25.0%, p = 0.034; 7.5% vs. 15.0%, p = 0.032; respectively).

Conclusions

CHM was associated with a lower need for FFP and platelet transfusions. Thus, CHM is a safe and effective alternative to GHM.

Trial registration

ClinicalTrials.gov, NCT 04310150
Capabilities of the automated information support module for the oil and gas industry operator
Authors: Gromov Z. A. , Belykh L. I.
Published: October 2022

In the Russian Federation, the number of accidents and fatal injuries to oil and gas industry workers is growing, which requires the development of labor protection measures. Among the effective measures are information software technologies including the automated information support module for the gas and oil production and processing operator. The present study aims to analyze this module. The research objects are types of work performed by a commodity operator: maintenance of tanks, shut–off valves, pressure gauges, oil release. The subject is technological operations and production factors of technogenic risks which were taken into consideration when developing the automated information support module. A brief description of the module, its navigation on the main pages and their functions is provided. The algorithm for the safe work of the commodity operator and a list of block diagrams were analyzed. The main features of this module were described. Taking into account the production factors and workplace activities, the contribution of the module to the values of occupational risk was estimated. The conclusion about the use of a module that reduces risks and improves safety at oil and gas industry enterprises was made.
Learning Coulomb Diamonds in Large Quantum Dot Arrays
Authors: Krause Oswin , Chatterjee Anasua , Kuemmeth Ferdinand , van Nieuwenburg Evert
Published: October 2022

We introduce an algorithm that is able to find the facets of Coulomb diamonds in quantum dot arrays. We simulate these arrays using the constant-interaction model, and rely only on one-dimensional raster scans (rays) to learn a model of the device using regularized maximum likelihood estimation. This allows us to determine, for a given charge state of the device, which transitions exist and what the compensated gate voltages for these are. For smaller devices the simulator can also be used to compute the exact boundaries of the Coulomb diamonds, which we use to assess that our algorithm correctly finds the vast majority of transitions with high precision.
The Effect of Whey Protein Concentrates on Technological and Sensory Quality Indicators of Ice Cream
Authors: Gurskiy Igor , Tvorogova Antonina
Published: October 2022

The demand for protein-fortified foods is increasing, and so is the necessity of the complete utilization of milk constituents in the food industry. The research objective was to study various technological and sensory indicators of ice cream fortified with whey protein concentrate.

The study featured ice cream samples with 8% of mass fraction of fat and 10% of nonfat milk solids with whey protein concentrations of 1–5 %. The dynamic viscosity was studied by rotational viscosimetry, dispersion – by microstructural methods, thermal stability – by thermostatic methods, and titratable acidity – by standard methods.

Whey protein concentrate in amount of 1–5 % increased the titratable acidity by 1.05–1.90 times and the dynamic viscosity – by 1.16–2.90 times. With an extra addition of 4% whey protein concentrate, the viscosity of the mix exceeded the technologically permissible values. The consistency coefficient increased by 19.4 times, and the flow index decreased by 4.8 times. During freezing, the mix revealed the high capability to air saturation with mass fraction of melt whey protein concentrate of 1 and 2%. Thermal stability also increased: mass fraction of melt after 60 min of retention decreased by 3 times. After adding 1–3% whey protein concentrate, the dispersion of air bubbles and ice crystals improved. It was determined in accordance with the density of distribution by their sizes. The hardness of ice cream decreased 1.4–8.3 times as whey protein concentrate increased. A greater mass fraction of whey protein enhanced the creamy taste and improved the texture.

Based on the main technological and sensory quality indicators, the mass fraction of whey protein concentrates should be under 3%. The results may be used in protein-fortified ice cream production.
Biological Safety Assessment of Antarctic Krill Euphausia superba (Dana, 1852) from the Atlantic Ocean
Authors: Lazareva Olga , Sytov Aleksandr
Published: October 2022

The development of the Antarctic krill fishery is a promising direction of Russian food industry. Euphausia superba is the largest source of animal protein in the global oceans. According to the Commission for the Conservation of Antarctic Marine Living Resources (CCAMLR), the year of 2021 saw a steady increase in the global catch of krill. The Government of the Russian Federation approved a program for the development of the oceanic fishery for crustaceans. The assessment of its biological safety is of particular interest because the extraction of this raw material in Russia is currently undergoing a restoration process. The purpose of the study was to analyze samples of Antarctic krill E. superba for parasites and microorganisms that could affect its sanitary condition.

The study featured the microplankton of E. superba crustaceans (n = 130) caught in 2019–2020 by the Federal Agency for Fishery. The methods included an incomplete helminthological analysis, as well as compressor, microbiological, and histological studies.

The visual inspection, helminthological dissection, and compressor microscopy revealed no helminth larvae or protozoa. In a microbiological study for safety indicators according to CU TR 021/2011, EAEU TR 040/2016 and Sanitary Rules and Norms SanPiN 2.3.2.1078-01, the quantity of mesophilic aerobic and facultative anaerobic microorganisms (QMAFAnM) were did not exceed 1.0×103 at 37 and 25°C. Opportunistic and pathogenic microorganisms were not detected. When examining cultivate for the isolation of Staphylococci, were found Cocci, but we did not identify them. When the material was sown on the Sabouraud nutrient medium at 24°C, Penicillium microscopic fungi grew on the plates in the amount of 3.0×102. Histological examination of carapace, gills, and internal organs detected no parasitological organisms, pathological inclusions, or any tissue changes.

The Antarctic krill contained no parasites and was microbiologically safe. After tests on Vibrio parahemolyticus and Listeria monocytogenes, it can be used in the food industry.
Phase Transitions of Sweetened Condensed Milk in Extended Storage Temperature Ranges
Authors: Ryabova Anastasia , Tolmachev Vladislav , Galstyan Aram
Published: October 2022

Sweetened condensed milk is a popular food in various climatic zones, including those regions where average winter temperature falls below –30°C. Such low temperatures can trigger crystallization because they disrupt the native structure of biopolymers. These processes spoil the quality of sweetened condensed milk. However, no scientific publications feature the cryoscopic temperature of sweet condensed milk or systematize the data on its low-temperature storage.

Sugar, sugar-milk, and milk solutions of various concentrations were frozen to determine their cryoscopic temperature by the thermographic method using a Testo 176T4 meter (Germany) with K-type probes (NiCr-Ni) at –78.5°C. The phase transitions were studied using a Mettler Toledo DCS 822e DSC analyzer.

The nucleation temperature, the cryoscopic temperature, and the subcooling degree depended on the concentration and the type of the solute. For sugar solutions, the cryoscopic temperature varied from –0.4 ± 0.1 to –6.4 ± 0.1°C; for sugar-milk solutions, it ranged from –2.1 ± 0.1 to –10.9 ± 0.1°C; for whole milk solutions, it was from –0.4 ± 0.1 to –4.6 ± 0.1°C. The thermographic method failed to obtain the phase transition and the cryoscopic temperature in analogue models of sweetened condensed milk. The loss of fluidity was about –30°C when the storage time exceeded 2 h. This effect was comparable to 54 min of storage at –35°C. The differential scanning calorimetry meth od showed that the phase transition occurred at –80°C.

This research opens new prospects for differential scanning calorimetry studies of phase transitions in condensed sweetened dairy products.
Alcoholic Drinks with Tomato Products
Authors: Chusova Alla , Zharkova Irina , Korkina Angelina , Pronkina Alena , Khitsenko Viktoria
Published: October 2022

New alcoholic and non-alcoholic beverages from non-traditional vegetable raw materials expand the domestic product range and allow food producers to develop new market segments. The present research objective was to summarize and analyze the current data on the use of tomatoes in alcohol production.

The review covered Russian and foreign open access scientific publications and patents registered in Pubmed, E-library, Cyberleninka, Espacenet, and Patentscope in 2005–2021.

Most publications featured tomato juice in soft drinks production as a means to increase their nutritional value, improve sensory profile, expand the product range, and develop new functional products, e.g., with antioxidant properties, for diabetic consumers, etc. Tomato pulp, juice, or puree is used in beer production. No publications featured the effect of tomato cultivars on the technical properties of the finished product.

The analysis revealed the need to study the effect of red, yellow, and dark tomatoes on the sensory and physico-chemical quality of beer drinks. Another research prospect is a novel semi-finished product from tomato pomace that would increase the nutritional value of beer drinks.
Pengaruh Organizational Justice dan Employee Engagement terhadap Organizational Citizenship Behavior Karyawan
Authors:   Bisnis Hospitaliti, Politeknik Pariwisata Nusa Dua Bali, Jl. Dharmawangsa, Benoa, Kec. Kuta Sel., Kabupaten Badung, Bali 80361, Artajaya Made , Pratama Akbar ,   Bisnis Hospitaliti, Politeknik Pariwisata Nusa Dua Bali, Jl. Dharmawangsa, Benoa, Kec. Kuta Sel., Kabupaten Badung, Bali 80361
Published: October 2022

The management of InterContinental Bali Resort applies two policies, which are organizational justice and employee engagement that expected to be able to improve organizational citizenship behavior in ought to increase employee performance, especially those dealing directly with guests, one of it is F&B Service Department. This study aims to analyze the influence of organizational justice and employee engagement on organizational citizenship behavior partial and simultaneous F&B Service Department employees at InterContinental Bali Resort. Determination of samples using saturated sample techniques totaling 78 respondents. Data collection techniques used were questionnaires. This research was conducted using multiple linear regression analysis techniques, t-test, F-test and determination coefficient analysis (R2) with the help of SPSS version 22. The results of the analysis showed that (1) organizational justice (X1) had a positive and significant effect partial to organizational citizenship behavior (Y), (2) employee engagement (X2) has a positive and significant effect partially on organizational citizenship behavior (Y), and (3) organizational justice (X1) and employee engagement (X2) positive and significant influence simultaneously on organizational citizenship behavior (Y). The results of the coefficient of determination analysis (R2) show that organizational justice and employee engagement have an effect of 59.7% on organizational citizenship behavior, while the remaining 40.3% is influenced by other variables not discussed in this study.
Optimalisasi Sistem Social Media Marketing untuk Membangun Awareness dengan Membuat Konten Online
Authors:   Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Rafi Raihanda , Fajrian M. Risvan ,   Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Jayawardhana Irman ,   Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Miradiarsyah Junas ,   Mahaka Sport Group, Jl. Ciranjang No.30, RT.6/RW.3, Rw. Bar., Kec. Kby. Baru, Kota Jakarta Selatan, Daerah Khusus Ibukota Jakarta 12180
Published: October 2022

The research explained about a sport event called Event Basket Pro that has been established since 2003, Event Basket Pro is one of professional basketball league in Indonesia and runs for approximately 8 months every season. Improvements are needed to make this event sustain, despite the fact that this event has operated for more than 15 years. Based on the research that was conducted using Soft System Methodology, it was found that Event Basket Pro having difficulties to create relevant digital marketing content related to their marketing target. The author suggested optimalizaton the system of social media marketing. In order to achieve it, according to the recommendation of conceptual model, every stakeholders had to play their role in planning, implementing and evaluation.
Differences in Processing and Presentation of Indonesian Food in America and Indonesia
Authors:   Tourism Department, Faculty of Tourism, Universitas Ciputra Surabaya, Indonesia. Citra Land CBD Boulevard, Made, Kec. Sambikerep, Kota Surabaya, Jawa Timur 60219, Gunawan Steven , Lis Indrianto Agoes Tinus ,   Tourism Department, Faculty of Tourism, Universitas Ciputra Surabaya, Indonesia. Citra Land CBD Boulevard, Made, Kec. Sambikerep, Kota Surabaya, Jawa Timur 60219
Published: October 2022

A fine food is a food that represent itself where it came from even those food is made far away from original place. Originality of food remain consistent while the taste and presentation may deliberately change to fit the culture and personal habit of the original citizen. The main objectives of this study are to recognize and describe the different process and presentation of Indonesian food that has been made in two specific different countries, Indonesia dan America. This research was conducted through textual analysis and qualitative data collection namely by personal observations, interviews, and documentations. This research observes the cultural and habitual action of the people who lived in Indonesia and America. The findings show variation in the aspect of processing and presenting Indonesia food in Indonesian and American context. The same food and ingredients may be different in the presentation and processing based on the cultural background of the place where the food is produced. Although this research analyzes specific context of places, but essence of culture that affect the food presentation and processing can be applied in any regions and culture.
Analysis Visitor Satisfaction Level of Outdoor Recreation in Bogor Botanical Gardens
Authors:   Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar No.17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia, Irfan Muhammad , Dinitri Seruni ,   Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar No.17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia
Published: October 2022

Bogor Botanical Gardens is a conservation area that has long been used by the wider community as a tourist attraction and has become one of the most popular tourist destinations because it presents a panoramic view of natural landscape architecture. This research was conducted to find out how Outdoor Recreation in Bogor Botanical Gardens can provide tourist satisfaction and how the influence of Outdoor Recreation on tourist satisfaction. The purpose of this study is to analyze Outdoor Recreation in the level of tourist satisfaction, and how much influence Outdoor Recreation has on tourist satisfaction. The research method used is the Importance Performance Analysis (IPA) Method with the aim to provide an illustration and illustrate the gap between the interests and satisfaction of individual attributes both of which are easy to understand and understand well through these measurements. Quantitative methods, to obtain more comprehensive data, do valid and reliable testing. The results of the merging of the performance of Bogor Botanical Gardens (performance) and the level of tourist expectations (Importance). divided into 4 quadrants as an indicator of overall tourist satisfaction through 100 respondents. The determination of the position of the 11 research attributes is determined based on the average value of both the level of importance and performance. Determination of the X (performance) of 3.62 and Y (Importance) of 3.63, obtained from the total average of all 11 average values for both the performance of the Bogor Botanical Garden (performance) and the level of tourist expectations (Importance).Through this research phase, it is expected that there will be an increase in tourist facilities by the Bogor Botanical Gardens, so that it can provide satisfaction in accordance with the expectations of tourists during the tour and create sustainable tourism in every tourist attraction in the Botanical Gardens
Perancangan Mekanisme Partisipasi Komunitas dalam Program Kerja POKDARWIS di Kampung Bekelir
Authors:   Program Studi Event, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia, Shofani Rizka Witha , Bonetha Sylvia ,   Program Studi Event, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia, Hartono Yudo ,   Program Studi Event, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia, Zulandari Peni ,   Program Studi Event, Universitas Prasetiya Mulya, Kampus BSD, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama, BSD City, Kec. Pagedangan, Tangerang, Banten 15339, Indonesia
Published: October 2022

This research was conducted from April to August 2019, focusing on Kelompok Sadar Wisata (POKDARWIS) in Kampung Bekelir, Tangerang. POKDARWIS is a form of organization which aims for the enhancement of local community’s role and authority as the subject of tourism development in a certain area. Increases in the community’s well-being, especially in the economic well-being, becomes the expected outcomes of every project made by POKDARWIS. Based on the research that was conducted using Soft System Methodology, researchers found that POKDARWIS in Kampung Bekelir had difficulties in creating its own project. Therefore, to make sure that POKDARWIS’ projects are suitable with the needs and the wants of the local comunity, they need to actively participate in the decision making process of POKDARWIS’ project. In order to achieve an active community participation, the local community needs to be included from the planning, implementation, to the evaluation of a project.
Pengaruh Persepsi Harga, Kualitas Layanan dan Fasilitas Wisata pada Kepuasan Pengunjung Wisata
Authors:   Hotel Operation, Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar Jl. Yasmin Raya No.17, Curugmekar, Bogor Barat, Kota Bogor, Jawa Barat 16113, Falaq Muhammad , Sjukriana Juke ,   Hotel Operation, Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar Jl. Yasmin Raya No.17, Curugmekar, Bogor Barat, Kota Bogor, Jawa Barat 16113, Nur Afifah Hasna ,   Faculty of Management and Business, Mercu Buana University, Jl. Meruya Selatan, Kembangan, Kota Jakarta Barat, Daerah Khusus Ibukota Jakarta 11650
Published: October 2022

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh Persepsi Harga Kualitas Pelayanan dan Fasilitas Wisata terhadap Kepuasan Pengunjung. Objek penelitian ini adalah pengunjung Tangkuban Perahu yang berada di Kota Bandung, Jawa Barat. Teknik pengambilan sampel dalam penelitian ini adalah Convenience Sampling. Responden dalam penelitian ini sebanyak 150 responden dengan menggunakan Structural Equation Model (SEM) dengan alat analisis Smart-PLS. Hasil penelitian yang telah diperoleh setelah dilakukan pengujian Model Struktural/Uji Hipotesis (Inner Model) menunjukkan bahwa Persepsi Kualitas Harga Kualitas Pelayanan dan Fasilitas Wisata berpengaruh terhadap Kepuasan Pengunjung Tangkuban Perahu Bandung Jawa Barat. Variabel Persepsi Harga berpengaruh positif dan signifikan terhadap Kepuasan Pengunjung Tangkuban Perahu Bandung Jawa Barat. Variabel kualitas pelayanan berpengaruh positif dan signifikan terhadap kepuasan pengunjung Tangkuban Perahu Bandung Jawa Barat. Dan Variabel Sarana Wisata berpengaruh positif dan signifikan terhadap kepuasan pengunjung Tangkuban Perahu Bandung Jawa Barat.
Can Game Fix Reality? Analisis Serious Game sebagai Produk dalam Pemasaran Sosial
Authors:   Sekolah Pasca Sarjana Universitas Gadjah Mada, Jl. Teknika Utara, Pogung, Sinduadi, Mlati, Sleman, D.I Yogyakarta, 55284, Hartono Yudo , Suprihanto John ,   Sekolah Pasca Sarjana Universitas Gadjah Mada, Jl. Teknika Utara, Pogung, Sinduadi, Mlati, Sleman, D.I Yogyakarta, 55284
Published: October 2022

Penelitian yang mengaitkan permainan, pemasaran sosial dan pariwisata belum terlalu banyak digali sehingga masih terbuka ruang untuk melakukan kajian terutama terkait bagaimana sebuah permainan dapat membantu meningkatkan awareness terhadap isu lingkungan yang terkait dengan konteks sustainable tourism. Tujuan penelitian ini menjelaskan proses pengembangan permainan (serious game) dari perspektif desainer sebagai sebuah produk dalam konteks pemasaran sosial. Studi ini dilakukan dengan menggunakan metode wawancara kepada desainer pengembang serious game dan analisis tematik untuk memetakan berdasarkan framework yang digunakan. Temuan menunjukkan bahwa upaya untuk membangun dan mengembangkan ide produk sesuai dengan atribut dapat dikembangkan pada proses penciptaan produk sosial. Serta terdapat peluang dalam menambahkan benefit pada sisi augmented product yang masih sangat terbuka luas untuk dieksplorasi. Implikasi dari penelitian ini para desainer dapat menggunakan framework ini untuk menciptakan produk dengan berorientasi pada target audience nya untuk menciptakan diferensiasi dan dapat merencanakan benefit baru diluar standar produksi game sebagai produk sosial pada umumnya untuk mencapai objektif game secara lebih optimal.
Transform the Paradigm of Conventional to Advanced Cooking Process
Authors:   Hotel Operation, Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar No. 17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia, Sjukriana Juke , Falaq Muhammad ,   Hotel Operation, Sekolah Tinggi Pariwisata Bogor, Jl. Curug Mekar No. 17, Yasmin. Kota Bogor, Jawa Barat 16113, Indonesia
Published: October 2022

Hotel Salak The Heritage, a four star hotel in Bogor, has conducted the research for developing and producing spice powder in cooperation with PT AGFI which already exists in Sundanese food industry. The spice powder is produced by using stable pressure, low temperature drying process (50-60°C) and intensive quality controls, which result in low water content and hygienically excellent product, as it is free from bacterial filth and other impurities. Since this product only consists of natural ingredients, it gives a standard flavoring effect and no unwanted colors to the end food product. Hotel Salak has made some experiments on the effectiveness of cooking process using spice powder, one of the examples is Beef Rendang, and saves cooking and preparation time up to 16.7% and saves cost up to 9.36 %. This is expected to change the paradigm of conventional to more effective, efficient and clean cooking process.
PengembanganProduk Teh Sereh InstanKhas Saung Sarongge yang Pertama dan Satu-Satunya di Desa Ciputri
Authors:   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Kenneth Henrikus , Sadjoli Nicole ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Debian Rinaldy ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Dewi Anggraini Stefany ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Yedidya Stefanus ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Reynaldi William ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339, Yuliati Retno ,   School of Business and Economics Universitas Prasetiya Mulya, BSD City Kavling Edutown I.1, Jl. BSD Raya Utama No.1, BSD City, Kec. Pagedangan, Kabupaten Tangerang, Banten 15339
Published: October 2022

Sereh Seungit is a dried lemongrass tea brand which is known as the drink of Kampung Sarongge, Cianjur. As a Small Medium Enterprise, its production is still lacking in consistency, quality, efficiency, and the partner’s capability on its production management. The community development programsaim to help partner to solve the problems by optimizing the production aspect of Sereh Seungit so it will be able to grow as a Small Medium Enterprise and increase the productivity of Saronge Village. The solutions offered includes the making of a Standard Operating Procedure, the addition in production equipment, and the partner’s training regarding production managementFrom the solutions implemented, partner established product standard, and partners have production management capabilities.
IMPLEMENTASI PENCEGAHAN PENYAKIT MELALUI PENYULUHAN KESEHATAN DI DUSUN SAPAN UNTUK MENURUNKAN ANGKA KESAKITAN (MORBIDITAS)
Authors:   Rekam Medik & Informasi Kesehatan, Politeknik Piksi Ganesha Bandung, Setiatin Sali , Trimasuti Wahyu ,   Komputerisasi Akuntansi,Politeknik Piksi Ganesha Bandung, Christinawati Santy ,   Rekam Medik & Informasi Kesehatan,Politeknik Piksi Ganesha Bandung
Published: October 2022

Program pengabdianini bertujuanuntuk melaporkan hasil pengabdian kepada masyarakat tentang Implementasi Pencegahan Penyakit Melalui Penyuluhan Kesehatan Di Dusun Sapan Untuk Menurunkan Angka Kesakitan (Morbiditas).Metode yang digunakan dalam penelitian ini adalah metodekualitatifdengan pendekatan deskriptif. Teknik pengumpulan data yang digunakan melalui observasi,wawancara,penyuluhan dan kajian pustaka yang berkaitan dengan pokok permasalahan.Dari penelitian yang telah dilakukan, permasalahan yang dihadapi aara lain: 1) Tingginya angka morbiditas di Desa Sumbersari dusun Sapan, 2)Kurangnya pengetahuan masyarakat tentang PHBSdan kesadaran masyarakat akan membuang sampah pada tempatnya, 3) Tidak tersedianya tempat sampah disekitaran jalan.Saran yang diberikan kepada masyarakat yaitu:1) Masyarakat perlu mengetahui dan sadar tentang penyakit menular dan tidak menular serta penerapan PHBS, 2) Puskesmas perlu meningkatkan sosialisasi dan penyuluhan kesehatan kepada masyarakat,3) Pemerintah setempat menyediakan tempat sampah di pinggir jalan dan bank sampah disetiap dusun
System analysis of water-energy-food nexus of Bundelkhand region, India
Authors: Dhaarna Dhaarna , Devadas Varuvel
Published: October 2022

The challenges in drought-hit Bundelkhand are stemming from policy constraints and insecurity of water, energy, and food resources, which have triggered mass migration, unemployment, indebtedness, and farmer suicide. Among the surveyed households of Banda District, 21% have no electricity, 90% are using fuelwood and cow dung for cooking purposes, 70% are engaged in agriculture, per capita food consumption is very low, and 51% of the households are using less than 40 lpcd (liters per capita per day) of water. The research methodology is unique is tailored to the WEF nexus approach. It analyzes the primary data of 534 households, 33 experts (Delphi Technique), and the secondary data of 189 articles. The Causal Loop Diagrams capture the system's dynamic behavior and establishes interconnectedness of the identified control parameters using the systems approach. Major parameters for agricultural production are productivity, productive area, and cropping intensity, while major water demand comes from agriculture, industrial, and domestic use. The energy sector is identified as the most challenging in this region, and the total generation comes from solar, biogas, fossil fuels, and organic fuels. This study concludes with findings suggesting urgent actions to be taken for regional sustainability and policy recommendations at the local level.
Ranking of general circulation models for Surat City by using a hybrid approach
Authors: Sharma Arpit , Kale Ganesh D.
Published: October 2022

Climate change is expected to worsen flood risks by increasing precipitation in and around Surat City. Thus, to study the effect of climate change on Surat City's stormwater drainage network, ranking of general circulation models (GCMs) and generation of future annual maximum rainfall series is needed, which has not been performed by any reviewed study and is performed in the present study by using a hybrid approach. The ‘hybrid approach’ refers to the combination of past performance approach used for ranking of GCMs and envelope approach based on future climate projections. To rank 21 GCMs belonging to Coupled Model Intercomparison Project Phase 5, a past performance approach is employed by using four performance indicators, which are evaluated on the basis of Surat's simulated and observed monthly rainfall data corresponding to the period 1969–2005. By using an entropy method, weights are assigned to different performance indicators and then ranking of GCMs is performed by employing the TOPSIS method. The top five ranked GCMs are used to generate future annual maximum rainfall series by employing the Reliability Ensemble Averaging method corresponding to Representative Concentration Pathways scenarios 4.5 and 8.5. This study will be helpful for future climate and hydrologic studies to be performed in the study area.
Valdivia ciudad de encuentros: historia y ciencia
Authors:   Universidad Católica de la Santísima Concepción, Cancino Juan Miguel
Published: October 2022

Esta presentación fue generada teniendo como tema central el Afiche que anuncia el Congreso, las especies animales y vegetales que en este aparecen, sus nombres científicos y los autores que las describieron, o que primero hablaron de ellas en términos científicos. El otro eje organizador es el de la historia de Valdivia, y su emplazamiento. Hemos agregado un elemento que no estaba presente en el Afiche del Congreso, simbolizando así el conocimiento científico de una planta endémica de esta tierra, recolectada por Claudio Gay y descrita como Valdivia gayana por Rémy 1847. Amalgama perfecta del lugar de origen de la planta, en el género Valdivia, homenaje al recolector, en el epíteto específico gayana, y del conocimiento científico sin fronteras, el botánico francés Rémy, que la describió en el año que se indica. Los mapas de los lugares de avistamiento reciente(*) de Valdivia gayana y de Alsodes norae, ilustran el endemismo y el estrecho rango de distribución geográfica de muchas de la especies de la selva lluviosa Valdiviana, y, son una invitación a conocer y a trabajar por la preservación de este patrimonio natural único e irrepetible
Influência do ribeirão dos Pinheiros na qualidade de água do rio Atibaia, sub-bacia do rio Atibaia, São Paulo, Brasil
Authors: Venancio Letycia , Borba Ricardo
Published: October 2022

Esta pesquisa teve como objetivo avaliar o impacto da qualidade da água do ribeirão Pinheiros na qualidade das águas do rio Atibaia, por meio de análise estatística e análise da concentração espaço-temporal dos dados de monitoramento de parâmetros físico-químicos e microbiológicos pré-existentes. Foi realizada pesquisa documental de dados de monitoramento de parâmetros físicos, químicos e biológicos disponibilizados pela CETESB, através do Sistema de Informação InfoÁguas. Após análise temporal e espacial foram utilizadas 3 estações de monitoramento para avaliação da qualidade das águas superficiais através da série histórica de dados no rio Atibaia (estações ATIB02035 e ATIB02065) e do ribeirão dos Pinheiros (PINO03900), entre anos de 2009 a 2019. Os valores dos parâmetros das amostras foram analisados considerando sua equivalência às classes estabelecidas na Resolução CONAMA nº 357/2005. Para o Índice de Qualidade das Águas (IQA) foram selecionadas amostras das estações de monitoramento de qualidade de água estudadas, as quais contém dados dos 9 parâmetros utilizados no cálculo. O Índice de Qualidade das Águas (IQA) anual médio do ribeirão dos Pinheiros (estação PINO03900) é aceitável, enquanto o índice do rio Atibaia (estações ATIB02035 e ATIB02065) é bom, tanto para as águas antes do ribeirão dos Pinheiros (Estação ATIB02035) quanto para as águas após o desague do ribeirão dos Pinheiros (Estação ATIB02065). Após análise generalizadas, destaca-se que os parâmetros nas águas do ribeirão dos Pinheiros que mais influenciam nas águas do rio Atibaia são coliformes termotolerantes, demanda bioquímica de oxigênio, nitrogênio, fósforo, resíduo total e oxigênio dissolvido.
Design, Synthesis, and Anti-Cancer Activity Evaluation of a 3-methyleneisoindolin-
1-One Library
Authors: Mehta Saurabh , Mangyan Mangeram , Brahmchari Dhirendra
Published: October 2022

Background:

Isoindolin-1-ones are medicinally privileged heterocyclic compounds. Due
to the interesting biological activities exhibited by these compounds, several synthetic and medicinal
research groups have developed numerous synthetic approaches for these compounds. We have
also previously reported two efficient approaches for the synthesis of the isoindolin-1-ones through
iodoaminocyclization of alkynyl amides using n-BuLi and phosphazene superbases.

Objective:

This study aimed to construct a medium-size library of multi-substituted 3-
methyleneisoindolin-1-ones and study its biological profile, specifically anti-cancer activity.

Methods:

Solution phase parallel synthesis was performed for the synthesis of the 3-
methyleneisoindolin-1-ones library through n-BuLi-mediated iodoaminocyclization of 2‑(1-
Alkynyl)benzamides. The iodocyclized products were further derivatized through palladiumcatalyzed
Sonogashira and Suzuki Miyaura couplings and N-alkylation reactions. In silico evaluation
of the physicochemical and ADMET properties was performed to examine the drug-likeness of
the library compounds. Selected isoindolin-1-one analogues were evaluated for in vitro antiproliferative
activity in various human cancer cell lines (MCF-7, A-549, and U-373 MG).

Results:

A library of 46 multisubstituted 3-methyleneisoindolin-1-ones has been synthesized. The
iodo-isoindolin-1-ones were synthesized in 66-76% yields through n-BuLi-mediated iodoaminocyclization
of 2‑(1-Alkynyl)benzamides. Further diversification afforded the diverse library members
in yields of 40–96%. Two of the library compounds exhibited GI50 values of < 10 μM in the human
breast cancer cell line (MCF-7).

Conclusion:

Isoindolin-1-one library was constructed through electrophilic cyclization. The diversification
was successfully performed through various C-C and C-N bond formation reactions. The
anti-proliferative activity of the library members appears to be arising from the interaction of the
compounds with the protein kinase drug targets.
Epigenetics in Eye Development and Ocular Disorders: A Brief
Review
Authors: Kuchay Raja Amir Hassan , Hassan Asima , Mir Yaser Rafiq
Published: October 2022

Epigenetics is a powerful regulator of gene expression. With advanced discoveries
in underlying molecular mechanisms that can alter chromatin response to
internal and external signals, epigenetic alterations have been implicated in various
developmental pathways and human disorders. The extent to which this epigenetic
effect contributes to eye development and progression of ocular disorders is currently
less defined. However, emerging evidence suggests that epigenetic changes are relevant
in the development of eye and ocular disorders like pterygium, age-related macular
degeneration, glaucoma and more. This brief review will discuss the relevance of
epigenetic mechanisms like DNA methylation, histone modifications, polycomb proteins
and noncoding RNAs in the context of eye development and selected ocular disorders.
The Role of Vitamins in DNA Methylation as Dietary Supplements
or Neutraceuticals: A Systematic Review
Authors: Fareed Muhammad Mazhar , Ullah Sana , Qasmi Maryam , Shityakov Sergey
Published: October 2022

Epigenetic modifications play a vital role in gene regulation associated with
different pathologies. Various nutrients in our diet, such as vitamins can modulate these
epigenetic mechanism. They also can regulatenderlying pathophysiological factors
and processes that directly or indirectly. Most importantly, A, B, C, and D vitamins
have recently been shown to be involved in this type of regulation together with vitamins
E and K. Despite their effect on the DNA methylation process, an in-depth understanding
of vitamin-mediated epigenetic alterations have yet to be investigated.
Moreover, the role of vitamins in DNA methylation as nutraceuticals might be important
to use for targeted therapy of various human diseases. Overall, this review provides a
brief survey of the role of vitamins as epigenetic modulators or nutraceuticals, emphasizing
their potential in epigenetic therapy.