bluuebunny/crossref_metadata_2025 huggingface dataset:
Pulmonary Annulus Growth Pattern in Patients with Tetralogy of Fallot Prior to Surgical Repair
Authors: Al Kindi Hamood N , Al Kaabi Shamsa , Al Harthi Hasina , Al Harthi Thuraya , Al Habsi Ahmed , Kandachar Pranav
Published: December 2023

Objectives: The size of the pulmonary valve annulus often determines the feasibility of pulmonary valve preservation at the time of intracardiac repair of Tetralogy of Fallot. Currently, there is limited available data regarding the growth pattern and the determining factors that contribute towards pulmonary valve annulus growth. Methods: This retrospective study included patients who underwent surgical repair of Tetralogy of Fallot with or without prior palliation. These patients had an echocardiogram at the time of initial diagnosis and a second echocardiogram prior to intracardiac repair. The sizes of the pulmonary annulus, the right and left pulmonary arteries with z-scores were recorded. Patients with improvement in the pulmonary annulus z-scores between the 2 echocardiographic examinations were allocated in Group I (n = 46) and Group II (n = 68) were those with no improvement. Results: A total of 114 patients were included in the study. The right and left pulmonary arteries size and z scores improved significantly between the 2 echocardiograms. Although the median size of the pulmonary annulus increased between the 2 echocardiograms (6 and 7.9 mm; P<0.001), there was no significant change in the z-score (-2.2, -2.34; P = 0.185). Multivariate logistic regression analysis showed that gender, blood group, presence of collaterals, and palliation with Blalock-Taussig shunt had no impact on the improvement in pulmonary annulus z-score. Conclusion: In Tetralogy of Fallot, the pulmonary valve annulus z-score may not change significantly prior to the intracardiac repair. Although in certain subgroups there may be an improvement, there was no specific factor that could be identified and had an influence on this improvement.

Keywords: Tetralogy of Fallot; Pulmonary Valve; Pulmonary Artery; Modified Blalock-Taussig Shunt; Oman.
Troubleshooting During Temporary Epicardial Lead Implantation in a Child with an Erosive Twiddler’s Syndrome and Multiple Sternotomies
Authors: Maddali Madan M , Al-Jabri Ismail A , Patel Malay H , Abokwafa Amr M , Zacharias Sunny
Published: December 2023

Temporary epicardial cardiac pacing in patients with bradyarrhythmias may be used as a bridge to implantation of a permanent pacemaker. The temporary epicardial lead placement may sometimes necessitate a sternotomy that may pose a challenge in patients who have had multiple earlier sternotomies. The difficulty in accessing the epicardium for urgent implantation of temporary epicardial pacing leads depends on the extent of adhesions in such patients. We report an 8-year-8-month-old girl with a pacemaker with an extruded pulse generator and difficult myocardial access due to 5 prior transsternal procedures. The child presented to a tertiary care hospital in Muscat, Oman, in 2021. A trouble-shooting technique was adopted to achieve temporary epicardial pacing to provide time for a course of antibiotic therapy administration. A permanent transvenous pulse generator system was implanted after 7 days of temporary pacing.

Keywords: Heart Block; Artificial Pacemaker; Implanted Electrodes; Case Report; Oman.
The specific role of extracellular matrix metalloproteinases in the pathology and therapy of hard-to-heal wounds
Authors: Trojanek Joanna
Published: December 2023

Matrix metalloproteinases (MMPs) are zinc-dependent endoproteases responsible for the metabolism of extracellular matrix (ECM). MMPs can degrade the various ECM components as a variety of non-ECM molecules. Hyperactivity of MMPs and improper regulation or inhibition could lead to certain disorders, like non-healing chronic wounds. In chronic wounds, unlike in acute ones, there are always higher levels of MMPs due to the accompanying inflammation. Different proteases are responsible for this condition; nonetheless, blocking MMPs can help restore the wound’s healing ability. The level of MMPs can help indicate the prognosis of chronic wounds. In some cases, the healing process is delayed by microbial wound infections. Bacterial proteases may up-regulate the levels of MMPs produced by host cells. That means that both host MMPs as proteases secreted by the infecting bacteria need to be targeted to increase the healing capacity of the wound. MMPs activity modulating treatments by superabsorbent polymer dressings can improve healing rates of chronic wounds. The main goal of this review was presentation the specific role of metalloproteinases in the pathology and therapy of hard-to-heal wounds.
Molecular Detectıon of Canine Leishmaniasis in Northern Anatolia, Turkiye
Authors: Yucesan Banucicek , Ozkan Ozcan , Tuncer Sinem , Ocal Zekeriya
Published: December 2023

Background: Canin leishmaniasis (CanL), mostly caused by Leishmania infantum, is one of the most important vector-borne diseases in dogs in the Mediterranean region. In this study, we aimed to determine the disease profile in this region by firstly making microscopic and then molecular analyzes in the samples taken from the dogs.
Methods: Overall, 112 whole blood samples taken from dogs for clinical applications by a veterinarian in Cankırı between December 2021 and November 2022 were used. After blood collection, both thin and thick drop blood smear preparations were prepared and evaluated for Giemsa staining. L. infantum was investigated by Real time-PCR (RT-PCR) method from all blood samples. Sequence analysis and phylogenetic tree study were performed on positive samples.
Results: Both microscopic and RT-PCR analyzes were performed. In both studies, 3 of the 112 samples were positive. Because of the sequence analysis, they were L. infantum. Sequence analysis was performed from the samples found 3 positive. The phylogenetic tree was drawn by making NCBI (National Center for Biotechnology) data entries of the positive samples (Accession numbers: OQ184728, OQ184729, OQ184730).
Conclusion:  Dogs are important, as they are reservoir of this disease. In this study, 3 (2.7%) positive Leishmaniasis was detected in dogs in Cankırı. Ultimately, this should prompt discussion about new strategies going forward to combat infection caused by Leishmania.
Amphotericin B-Loaded Extracellular Vesicles Derived from Leishmania major Enhancing Cutaneous Leishmaniasis Treatment through In Vitro and In Vivo Studies
Authors: Davari Afshin , Hajjaran Homa , Khamesipour Ali , Mohebali Mehdi , Mehryab Fatemeh , Shahsavari Saeed , Shekari Faezeh
Published: December 2023

Background: Recent studies have shown an increasing number of patients with cutaneous leishmaniasis (CL) who do not respond to pentavalent antimonials as the first line of treatment for CL. Nanocarriers such as extracellular vesicles (EVs) are efficient vehicles that might be used as drug delivery systems for the treatment of diseases. Therefore, we aimed to isolate and characterize the EVs of Leishmania major, load them with Amphotericin B (AmB), and investigate the toxicity and efficacy of the prepared drug form.
Methods: The EVs of L. major were isolated, characterized, and loaded with amphotericin B (AmB), and the EVs-Amphotericin B (EVs-AmB) form was synthesized. Relevant in vitro and in vivo methods were performed to evaluate the toxicity and efficacy of EVs-AmB compared to the control.
Results: The anti-leishmanial activity of the EVs-AmB showed a higher percentage inhibition (PI%) (P = 0.023) compared to the AmB at different concentrations and time points. Obtained data showed a significant increase in the lesion size and parasite load in the lesion, PBS, and EVs mice groups in comparison with EVs-AmB, AmB, and Glucantime groups (P < 0.05), EVs-AmB had a significant decrease in lesion sizes in comparison with AmB (P < 0.05). Results showed that EVs-AmB decreased its toxicity to the kidneys and liver (P < 0.05).
Conclusion: EVs-AmB improved the efficacy of AmB in mouse skin lesions and reduced hepatorenal toxicity. Furthermore, EVs could be a promising nanoplatform for the delivery of AmB in CL caused by L. major.
Green Synthesis, Characterization, and Antileishmanial Activity of the Silver Nanoparticles Alone and Along with Meglumine Antimoniate against Leishmania major Infection
Authors: Majeed Qais Ahmed , Shater Abdullah Faisal , Alanazi Abdullah Daria
Published: December 2023

Background: The most commonly available drugs for leishmaniasis are pentavalent antimony compounds; whereas the recent studies showed various complications and limitations of these drugs. We aimed to green synthesized silver nanoparticles (AgNPs) and study the promising antileishmanial and synergic effects of green synthesized silver nanoparticles alone and combined with glucantime.
Methods: The precipitation technique was used to drop silver ions via an extract of Astragalus spinosus to AgNPs at Department of Biological Sciences, Faculty of Science and Humanities, Shaqra University, Saudi Arabia in 2022. Then, its anti-amastigotes, caspase-3-like activity, triggering the nitric oxide (NO) as well as its cytotoxicity effects on macrophage cells as well as effects on leishmaniasis in BALB/c mice infected by L. major were measured.
Results: The size of the AgNPs were ranging from 30-40 nm. The IC50 value for AgNPs, AgNPs+ meglumine antimoniate (MA), and MA was 59.3, 18.6, and 51.2 μg/mL, respectively. The determined FIC value for AgNPs and MA was found to be 0.31 and 0.36, respectively; demonstrating the synergistic potency of AgNPs when combined with MA. The diameter of CL lesions treated with various doses of AgNPs and AgNPs+MA notably (p<0.001) decreased. AgNPs, particularly at the concentrations of ½ IC50 and IC50, considerably triggered the caspase-3 activation. The calculated CC50 of AgNPs and MA was 612.5 and 789.8 μg/mL, respectively. Green synthesized AgNPs, especially in combination with MA had synergic antileishmanial effects and displayed a promising drug candidate for treating L. major CL.
Conclusion: We found satisfactory findings in the parasite reduction in both in vitro and animal models. Still, more studies are expected to explain the precise action mechanisms of AgNPs and their efficacy in humans.
Gelatin Zymography of Major Proteases in Exosomes of Leishmania major Promastigotes
Authors: Azambakhtiar Akram , Nabian Sedigheh , Mohebali Mehdi , Taheri Mohammad , Nezhad Fard Ramin Mazaheri
Published: December 2023

Background: Enzymatic digestion of extra cellular matrix proteins by proteinases of   Leishmania promastigotes is a complex process. Hence, studies on functional proteomics of these enzymes can help select these enzymes as possible vaccine candidates or selecting candidates for chemotherapy and immunotherapy. Several proteolytic enzymes are involved in virulence of Leishmania spp. These enzymes are mostly serine, cysteine and metalloproteases. We aimed to detect proteases in Leishmania promastigote exosomes.
Methods: Serine, cysteine and metalloproteases were investigated in exosomes and lysate of L. major promastigote using gelatin zymography. The study was carried out in the Faculty of Veterinary Medicine, University of Tehran, Tehran, Iran, in 2021.
Results: Zymography findings of metalloproteinases showed transparent bands, including a 63-kDa glycoprotein (GP63). This glycoprotein is a major surface metalloproteinase. In addition, transparent bands belonged to serin proteases and cathepsin were demonstrated in gels associated to Leishmania promastigote lysate and exosomes.
Conclusion: Several metalloproteases, serin proteases and cathepsins were shown in promastigote lysate and exosomes of L. major, which could purified and used as fractions for immunodiagnostic.
Misdiagnosis of a Patient with Hepatic Alveolar Echinococcosis with Hepatapostema: A Case Report
Authors: Wang Huiyao , Xia Qian , Wang Xiaoling , Zhang Xuhui , Ren Yelei , Wang Yifei , Li Yongzhong , Cai Diming
Published: December 2023

Alveolar echinococcosis (AE) is an important zoonotic tropical disease in China that affects people living in western endemic areas. The disease is prone to occur in the liver with a characteristic similar to slow-growing malignant tumors. We report a 31-year-old male patient with serious complication after hepatorrhaphy, who had presented with clinical manifestations of hepatapostema with infection. Ultrasound (US) and computer tomography (CT) are two important medical imaging modalities to diagnose hepatic AE. Based on the medical history, clinical findings, laboratorial and imaging results, the patient was misdiagnosed with hepatapostema. A series of subsequent treatments were ineffective. Finally, partial hepatectomy was performed, and postoperative pathological results confirmed hepatic AE. The patient has now recovered.
Assessing the efficacy of medical vs surgical approaches for treating carpal tunnel syndrome: Systematic review
Authors:   MRCGP UK, Elhamalawy Dr Ahmed
Published: December 2023

Background: Carpal tunnel syndrome (CTS) is the most common peripheral nerve entrapment syndrome that is caused by compression of the median nerve at the wrist joint causing variety of signs and symptoms. There are several measures to treat CTS including surgical and non-surgical approaches. Objectives: this systematic review aims to compare and evaluate the efficacy of conservative (non-surgical) and surgical approaches in treatment of CTS. Methods: Using predefined keywords related to this condition, an extensive search of medical databases, including PubMed and Cochrane library, was carried out to find and select randomized controlled clinical trials evaluating the effects of conservative treatment compared to surgical treatment released up to August 2023. The quality of the included research was rigorously evaluated, and data were extracted. After reviewing pertinent papers for relevance and quality, data was gathered for analysis. Key outcome measures included pain reduction and functional improvement
Application Nanobiotech in Neurodegenerative Diseases
Authors:   Career Point University, Alaniya, Kota, Rajasthan, India, Zayyanu Tukur
Published: December 2023

Background: An early pathogenic role for mitochondrial dysfunction in affected neurons, which occurs before morphological and functional abnormalities, is being supported by expanding information from studies on neurodegenerative diseases. Age is the primary risk factor for numerous diseases that affect people, the degenerative disorders are characterized by an abnormal protein accumulation, progressive loss of neuron cells, and impaired motor or cognitive abilities. One of the fundamental characteristics of aging is mitochondrial malfunction, especially in organs that need a lot of energy, such the heart, muscles, brain, or liver. Small amounts of ROS are produced by natural cell functions such aerobic respiration and inflammatory response mostly in macrophages and hepatocytes.
A Case Series on Clinical Profile, Risk Factors and Management of Idiopathic Intracranial Hypertension
Authors:   Resident, Department of Neurology, Coimbatore Medical College, Saleem EK Mohamed
Published: December 2023

Introduction Idiopathic intracranial hypertension (IIH) occurs when there is raised intracranial pressure (ICP) of unknown etiology and is diagnosed when all other causes of raised ICP have been excluded1 . IIH most commonly affects women of child-bearing age and overweight women2 . However, men, women of all ages and children of both genders are affected3 . Previously the terms like pseudo tumor cerebri and benign intracranial hypertension were used; however, in view of impending loss of vision it cannot be considered benign. Hence the term IIH is used nowadays. The diagnosis of IIH was made using modified Dandy criteria which includes presence of raised intracranial pressure, papilloedema, normal magnetic resonance imaging (MRI) and elevated CSF opening pressure with normal CSF composition. In the absence of papilledema, the diagnosis is challenging and requires specific neuroimaging criteria to be fulfilled.
Multiple Sinuses around Umbilical Port Site due to Atypical Mycobacterium after Laparoscopic Cholecystectomy- A Rare Case Report
Authors:   Junior Resident Department of General Surgery PGIMS ROHTAK, Sandeep Verma Vidit
Published: December 2023

Uncommon surgical site infection following laparoscopic cholecystectomy characterized by port site tuberculosis caused by atypical mycobacterium or non tubercular mycobacterium. This infection exhibited an atypical pattern spread of infection occurs within subcutaneous plane and leading to the formation of multiple abscesses and sinuses. Comprehensive management approach by surgical intervention by drainage and debridement of the affected area and long- term multidrug anti-tubercular therapy, resulting in complete healing of the sinuses. This case report highlights the importance of considering atypical pathogens in the differential diagnosis of surgical site infection and comprehensive management strategy. Keywords: Atypical Mycobacterium, Tuberculosis, Multiple sinuses, Anterior abdominal wall, Laparoscopic cholecystectomy
First Recorded Large-Scale Adoption of Virtual Reality as a Part of Curriculum
Authors:   M.S. General Surgery, FMAS, COO MediSim VR, Chinnaswami Dr Adith
Published: December 2023

Virtual Reality (VR) has been gaining traction as a medium of training for medical students, with various studies finding a multitude of advantages. These developments have led to its inculcation into educational institutions and programs. This study intended to understand the impact of using VR training on Indian medical students. Over 200 students from KIMS were enrolled in a VR-integrated curriculum program consisting of 10 modules across an academic year (Aug 2021-June 2022). After completion of all modules in the guided and evaluation modes, each student was asked to fill out an online questionnaire. An objective analysis of the results suggested that it was an interesting form of learning (61% of students), one that was more effective than manikin training (47%), bringing an increased level of confidence post training (92%). Feedback on the modules included satisfactory learning points, room for improvement in the visual graphics, and positive opinions on the assessment aspect. Overall, this study found that medical students perceived VR training as a fun and effective way to not only educate but assess them on procedural skills. Limitations included the need for repeated practice and the need to develop more realism in the digital environment to bring greater immersion. Keywords: Virtual Reality, Healthcare Training, VR Skill Training, Medical Simulation, KIMS.
Emotionality and Rationality of Participants in Women’s Civic Protests in Poland (the Case of the Greater Poland Voivodeship)
Authors: Wrzesień Witold , Ziółkowska Magdalena
Published: December 2023

After 22 October 2020, when the Constitutional Tribunal of the Republic of Poland announced the judgment on the protection of foetuses and grounds for permitting the termination of pregnancy, a vast wave of civic protests swept through Poland. During these protests, new spaces for expression of discontent and resistance that were previously absent during protests against the tightening of abortion laws emerged. Their innovation was largely based on creating boundary areas with their liminality clearly beyond the sub-world of protests. Relations between the emotionality and rationality of the protestors’ actions played a unique role in this process. This text is an attempt to diagnose the tendencies signalled above.
Ochotnicza Straż Pożarna. Socjologiczne konteksty fotografii pożarniczej
Authors: Marcysiak Tomasz
Published: December 2023

Ochotnicze Straże Pożarne to jedne z najstarszych i najaktywniejszych organizacji pozarządowych w Polsce. Ich działalność na przestrzeni lat podlegała wielu przemianom między innymi z powodu dynamicznego rozwoju Państwowej Straży Pożarnej, która przejęła na siebie większość działań ratowniczo-gaśniczych. Nie oznacza to osłabienia aktywności OSP, a jedynie przeniesienie ciężaru działań na imprezy integrujące lokalną społeczność, czy oprawę uroczystości świeckich i kościelnych. Wiele jednostek OSP nadal utrzymuje wysoką sprawność ratowniczą, bo choć na obszarach wiejskich odnotowuje się znaczny spadek pożarów, to jednak wciąż istnieją zagrożenia, podczas których w pierwszej kolejności interweniują strażacy-ochotnicy. W prezentowanym materiale wizualnym pokazano wydarzenia z udziałem OSP, które na stałe wpisane są w ich roczny kalendarz, między innymi: asystę honorową podczas Triduum Paschalnego, zawody strażackie i pokazy przedszkolnej drużyny strażackiej, ćwiczenia pożarnicze, dożynki gminne. Materiał ukazuje różnorodność umundurowania i przede wszystkim relacje pomiędzy strażakami, które w swym symbolicznym wymiarze stanowią najważniejszy czynnik podtrzymujący tradycję i tożsamość strażaków-ochotników oraz etos ich misji.
Sexual Violence in the Wattpad's Young Adult Novels: Feminist Studies
Authors: Darmawan Septhi Andini , Halimah H.
Published: December 2023

Nowadays, Indonesia is one of country labeled as sexual violence emergency country. Literature can be medium to expressed writer’s view about sexual violence in society, Wattpad as a platform to publishing popular novels can be one of them. Some of Wattpad teen novels choosen sexual violence as a conflict, and it is related to fact that teenager or adolescence was prone to becomed sexual violence victims. This study aimed to describe how sexual violence represented in Wattpad teen novels. Feminist literary criticsm applied in this study, and it shows that not only patriarchy system caused sexual violence, but also caused by juvenile delinquency. Furthermore, the sexual violence solution in Wattpad teenlit represented that some of society has been concerned to victim’s perspective.
Keywords : feminist literay criticism, sexual violence, teenlit, wattpad
Zakaj Platon potrebuje psihologijo? Predlog teoretičnega okvirja za raziskave o kognitivnem transferju učinkov študija klasičnih jezikov
Authors: Vereeck Alexandra , Janse Mark , De Herdt Katja , Szmalec Arnaud , Hauspie Cathy , Duyck Wouter
Published: December 2023

Psihologija je ena od sedmih vozliščnih znanosti, kar po eni strani psihologom nalaga veliko odgovornost, po drugi pa tako za psihologe kot druge znanstvenike prinaša mnogo priložnosti. Navedeno je bila tudi tema 17. Evropskega kongresa psihologije, ki ga je organiziralo Društvo psihologov Slovenije. V članku je podrobno predstavljen primer delovanja psihologije kot vozliščne znanosti. Raziskava svojo vsebino črpa iz na videz nepovezanega področja klasične filologije. Poučevanje latinščine in stare grščine ima v Evropi večstoletno tradicijo, še danes pa se teh jezikov učijo številni dijaki. Hkrati pa je tradicija učenja klasičnih jezikov tudi predmet očitkov, saj so ti v sodobni družbi pogosto zaznani kot nepomembni. Klasični filologi so zato prisiljeni, da branijo sam obstoj svoje stroke. Eden od njihovih argumentov je ta, da ima študij klasičnih jezikov pozitiven učinek na jezikovne in splošne spoznavne zmožnosti dijakov. Ta predpostavka je tesno povezana s splošnim vprašanjem transferja pri učenju, ki že dolgo zaposluje filozofe in psihologe. Edini način, da to tezo podpremo, je da se zatečemo k psihološki metodi. Članek predstavlja prvi celostno elaboriran teoretični okvir za opisovanje kognitivnega učinka učenja klasičnih jezikov in utira pot za metodološko ustrezno in rigorozno raziskovanje na tem področju. Teoretični okvir izhaja iz kognitivnega transferja kot osrednjega konstrukta in ga združuje z vpogledi iz psihološke in druge literature. Tako se vzpostavi plodna interakcija: ne samo, da psihologija prispeva k pomembnosti raziskovanja klasičnih jezikov, ampak s poseganjem na nova področja znanja oplaja tudi kognitivno psihologijo in psiholingvistiko.
Self-assessment of Internal Quality Assurance Mechanisms: An Empirical Investigation
Authors: KAGGWA FRED , Nabachwa Sarah , Kyoshaba Martha , Kalungi Dickson , Ambrose Atuheire Izaara , Nakakeeto Robinah F. , Agum Solomon
Published: December 2023

This study examines the internal quality assurance mechanisms (IQAMs) at Mbarara University of Science and Technology (MUST) in Uganda through a self-assessment. A descriptive design and quantitative method are employed to investigate various quality aspects from all faculties and all units of MUST. The units of inquiry were (i) the internal stakeholders of MUST i.e. current staff and students, and (ii) the MUST Alumni. Participants were sampled using stratified simple random sampling where faculties and specific programs formed the various strata. The student samples were drawn from the admission lists while the alumni email contacts were drawn from the archived information in the Academic registrar’s office. Staff lists were drawn from the Human Resources office. The study utilized a structured questionnaire based on the Inter-University Council of East Africa (IUCEA) model. Based on the target population and samples, 384, 76, and 371 responses were received from students, staff and alumni respectively. The study revealed that IQAMs were implemented in various areas including teaching and learning, research and innovations, and community outreach, but gaps existed in policies for skills development and community engagement. While the university had established quality assurance policies, there were concerns regarding their awareness and implementation. Diverse opinions among students and staff emphasized the importance of considering multiple perspectives. Alumni feedback highlighted positive outcomes in employability and program satisfaction, but suggested improvements in integrating practical components and enhancing university-industry collaborations. Based on the findings, recommendations were made to MUST, including the development of specific policies, strengthening implementation strategies, enhancing student engagement, addressing staff viewpoints, fostering alumni involvement, and strengthening university-industry connections. These recommendations aim to enhance internal quality assurance mechanisms and overall education quality. The study provides valuable insights into quality assurance practices at MUST and emphasizes the need for continuous monitoring and improvement to sustain educational quality. Future work should conduct a qualitative study to gain a deeper understanding of the self-assessment study and also the underlying reasons, motivations, and experiences that could have influenced the aforementioned quantitative findings.
Enhancing Higher Education Quality: A Proposed Internal Quality Assurance Model for Algerian Institutions
Authors: Benhacine Samir
Published: December 2023

This research focuses on the development and implementation of an internal quality assurance model tailored for Algerian higher education institutions. The study aims to address the specific quality enhancement needs of the Algerian higher education system by proposing a comprehensive internal quality assurance framework. The model takes into consideration the unique cultural, educational, and institutional context of Algeria while drawing inspiration from global best practices in quality assurance. The research involves a thorough analysis of existing quality assurance practices, stakeholder engagement, and the alignment of the proposed model with national educational goals. The findings of this study contribute to the ongoing efforts to improve the overall quality of higher education in Algeria and establish a robust framework for continuous enhancement.
Analysis of Cyclamate Content in Unbranded Instant Herbal Medicinal Drink on Market in the City of Pamekasan
Authors: Jamila Nur , Rahman Alief Putriana , Humaidi Fauzan
Published: December 2023

Jamu is one of the traditional medicines because most herbal medicine uses natural ingredients or plants. One of the safety of herbal medicine is the absence of abuse such as the addition of artificial sweeteners in the form of cyclamate. Cyclamate is one of the artificial sweeteners that has a sweetness level 30 times higher than natural sweeteners. Excessive use of cyclamate will cause cancer and tumors. The purpose of this study is to determine the presence or absence of cyclamate content and levels in ready-to-drink herbal medicine without a brand sold in the Pamekasan City market. This research was conducted qualitatively with precipitation methods and quantitative with gravimetric methods. From qualitative research, the results of sample A found a white precipitate which indicates a positive sample containing cyclamate. While samples B and C found no deposits indicating that the sample was negative cyclamate. Furthermore, a positive sample is carried out quantitative testing. In determining cyclamate levels, sodium cyclamate levels in sample A were obtained at 4.8047 g/kg. so that the serving rate or per 1 bottle of herbal medicine contains 115.312 g/0.6 kg and this exceeds the threshold determined by BPOM Regulations which is 1.25 g/kg. The conclusion of this study is that 1 out of 3 positive samples contains cyclamate with levels that exceed the threshold determined by BPOM RI No. 32 of 2019.
use of dermoscope to differentiate Pityrosporum folliculitis and Acne vulgaris
Authors: Tanojo Natalia , Anggraeni Sylvia
Published: December 2023

Background: Both Pityrosporum folliculitis (PF) and Acne vulgaris (AV) are chronic inflammation of pilosebaceous follicle but with different etiology. The similar findings may lead to misdiagnosis that worsen symptoms, especially if PF is treated with antibiotics meant for AV. A simple KOH examination helps to differentiate PF and AV is not always readily available in clinical setting.Purpose: to find an alternative, practical tool to confirm the diagnose of PF and AV.Review: Dermoscope is a handheld microscope equipped with 10x magnification and a light source for microscopic visualization of the subcutaneous structures. The monomorphic lesions in PF appear as hypopigmented, round lesions with coiled/looped hair in the center. Dermoscope image of AV varies according its polymorphic manifestations. A non-inflammatory AV shows a yellow-brown blockage in the center while inflammatory AV is depicted as round, whitish lesions with thin brownish borders and erythematous marginal lesions. Pustular AV appears as raised lesions with indistinct borders and white or yellowish in the middle and surrounding reddish borders.Conclusion: Dermoscope help to see skin structures invisible to naked eyes and thus, help to diagnose PF and AV.
Disability Level of Leprosy Patients in Ambon City, Maluku: A Retrospective Study from Eastern Indonesia
Authors: Pangestu Juan Felix , Manuputty Amanda  Gracia , Asmin Elpira , Tanamal Rita , Titaley Christiana Rialine , Tahitu Ritha , Bandjar Fitri Kadarsih
Published: December 2023

Background: Leprosy, also known as Hansen's disease, is a chronic endemic disease. The Corona Virus Disease 2019 (COVID-19) pandemic disrupted the implementation of the Neglected Tropical Diseases (NTDs) program such as the leprosy new case detection program. Leprosy is one of the chronic diseases that causes various problems due to the disability it causes. Purpose: To know the prevalence of leprosy and disability in 2018-2022 in Ambon City, Maluku, Indonesia. Methods: This research is a type of retrospective descriptive research whose aim is to find out the  epidemiology of leprosy patients in Ambon City, Maluku, Indonesia with a sample of were 131 people from 2018 to 2022. Result: The prevalence of disability levels 0 and 2 has the highest percentage in the 5-year span, occurring in 2019. However, during the COVID -19 pandemic, cases of level 1 disability tend to rise. Conclusion: Leprosy patients who had disability were more common  than those who had a disability.
Impact of Scabies on Sleep Quality
Authors: Azzahra Fatimah , Manuputty Amanda Gracia , Bandjar Fitri Kadarsih , Silalahi Parningotan Yosi
Published: December 2023

Background: Scabies is an infectious skin condition that occurs due to an infestation of the small parasitic mite known as Sarcoptes scabiei var. hominis. It causes symptoms of itching, which usually worsen during the night and can interfere with sleep. Purpose: The aim of the study was to examine how the incidence of scabies relates to the sleep quality of students at Al Anshor Islamic Boarding School in 2022. Methods: In this study, a quantitative approach was used with a cross-sectional research design. Primary data was collected through the diagnosis of scabies and the use of the Pittsburgh Sleep Quality Index (PSQI) questionnaire to measure sleep quality. Bivariate analysis was conducted using the chi-square test for data analysis. The research sample was obtained through the stratified random sampling method. Results: According to the findings, out of 42 participants, 26 students (61.9%) had scabies, with 11 males and 15 females affected. Most of the scabies cases were found in 17-year-old students. The study also found that all scabies sufferers had poor quality sleep. Statistical analysis revealed a significant association between the incidence of scabies and sleep quality, with a p-value of 0.000 and a 95% confidence interval. Conclusion: In conclusion, the study suggests that there is a link between the occurrence of scabies and sleep quality. Therefore, it is important to raise awareness about personal hygiene practices to reduce the spread of scabies.
Research Trend of Studies Regarding the Change and Treatment of the Skin on Pregnant Women in the Last Decade: A Systematic Review and Bibliometric Analysis
Authors: Nauli Agnes , Dalimunthe Dina Arwina
Published: December 2023

Background: The number of publications related to the change and treatment of the skin in pregnant women in the last decade has significantly grown. To date, however, a study offering comprehensive information related to the change and treatment of the skin in pregnant women has not been conducted or found in an electronic journal or proceeding. The purpose of this study is to present a bibliographic and bibliometric review of the numerous documents studying the skin of pregnant women. Methods: A systematic review involving bibliometric analysis with quantitative method was performed to carry out this studywhich 198 eligible documents from the Scopus database published in the period of 2013–2022 were used as research materials. Result: Results revealed that the publication and development of studies related to the change and treatment of the skin in pregnant women slightly soared from 2013 until 2022. Meanwhile, the citation development of he studies regarding the change and treatment of the skin in pregnant women tended to moderately decrease between 2013 and 2022. Additionally, influential documents, authors, countries, affiliations, and sources contributed to the development of studies related to the change and treatment of the skin in pregnant women. Discussion: In particular, this study informs us that the publication and development of studies related to the change and treatment of the skin in pregnant women slightly soared from 2013 until 2022. Most pregnant women undergo a skin change. This study implies that women must treat a skin change when they are pregnant.
The Effect of Sun Exposure on the Severity Degree of Photoaging and Skin Hydration on Service Workers at dr. Zainoel Abidin Regional General Hospital Banda Aceh
Authors: Wahyu Lestari  , Dinda Ayu Puspita  , Muhammad Mizfaruddin  , Sitti Hajar
Published: December 2023

Background: Photoaging is the aging of the skin characterized by the appearance of wrinkles, telangiectasis, solar elastosis, pigmentation and keratosis. Photoaging is usually caused by external factor, such as sun exposure. The radiation from the sun causes an increase of the reactive oxygen species (ROS). Cell damage, dry skin, photoaging, and skin cancer are all caused by the accumulation of ROS in the skin. Purpose: The goal of this study is to find out how sun exposure affects the severity of photoaging and skin hydration at dr. Zainoel Abidin Regional General Hospital Banda Aceh. Methods: This is an analytic observational study with an accidental sampling technique. Sun exposure was   measured by a questionnaire, the severity of photoaging was assessed based on the doctor's diagnosis, and skin hydration was assessed through an examination using a corneometer and tewameter.  Results: This study indicates that there is an effect of sun exposure and the severity of photoaging with p value of 0.016, while skin hydration shows a significant effect of sun exposure on hydration with a corneometer parameter with a p value of 0.031 Conclusion: There is a substantial correlation between sun exposure and the severity of photoaging. There is a substantial relationship between sun exposure and skin moisture, as measured by the corneometer parameter.
Generalized Pustular Psoriasis in Childhood: A Rare Case
Authors: Asnawi Vella , Maulida Mimi , Earlia Nanda , Hidayati Arie , Ismida Fitri Dewi , Liana Mahda Rizki , Maghfirah Karamina , Bulqiah Mikyal
Published: December 2023

Background: Generalized pustular psoriasis (GPP) rarely occurs under 10 years of age. GPP is typically characterized by an eruption of generalized pustules accompanied by systemic symptoms such as fever for several days, malaise, and anorexia. Pustules are sterile, with a size of 2-3 mm, and spread over the trunk and extremities. This disease can be life-threatening; therefore, optimal therapy is required. Purpose: to report a rare case of GPP in childhood. Case: A 4-year-old girl with complaints of widespread red patches that spread to her neck, back, and hands, with red patches turning into streaks that are partially pus-filled and itchy. In almost all parts of the body, skin abnormalities were seen in the form of generalized erythematous plaques, well-defined borders, multiple pustules on the edges, and some plaques covered by thick scales and crusts. In the calculation of body surface area (BSA), the result is 44%, and in the calculation of generalized pustular psoriasis area and severity index (GPPASI), the result is 21.30. The patient was treated with combination topical therapy of 3% salicylic acid, desoximethasone cream 0.25%, momethasone cream 0.1% vaseline albume as emollients, and coal tar. Significant improvement was seen after 1 month of therapy. Discussion: GPP in children is a rare case. GPP is idiopathic and can be life-threatening. Until now, there has been no standard therapy that is considered the most effective and safe for children. Topical therapy may be an option.
The Role of Socioeconomic Determinants on Individual Decision to Quit Smoking: Evidence from Indonesia.
Authors: Muhammad Rizkan , Nursani
Published: December 2023

The Global Adult Tobacco Survey in 2020 shows that Indonesia became the world’s third-highest number of smokers. This is due to the excessive consumption of cigarettes by the Indonesian people and the lack of awareness of the effects of smoking. This study aims to investigate the socioeconomics as an indicator that has a high probability of being a determinant of individual decisions in households to quit smoking and uses the latest Indonesia Family Life Survey (IFLS-5). The Probit approach was used to analyze the most identified factors for preventive ways and propose interventions to address those factors. We find some facts, namely (1) The higher the level of education and income of the individual in the household, the higher the probability of the individual’s decision to quit smoking; (2) unlike cigarette expenditure, the more significant the increase in cigarette expenditure, the lower the individual’s probability of quitting smoking; (3) but, unfortunately, the existence of a non-smoking area does not influence individuals in the household to quit smoking, this also applies to individual smokers who are sick. We also found that several control variables, such as (4) increasing age and marital status (married), had a positive effect on an individual’s decision to quit smoking; (5) individuals who were male had a lower probability of quitting smoking than females. In addition, (6) both individuals with marital status (divorced) and occupation do not affect the decision to quit smoking.
Mind the Gap: The Efficiency Convergence of ASEAN Plus Three Economies
Authors: Yasin Mohammad Zeqi
Published: December 2023

This study aims to examine the performance of technical efficiency convergence (Beta and Sigma convergences) of 10 ASEAN economies as well as other three main partners from East Asia, namely China, South Korea, and Japan for the years of 1990-2021, and addresses the determinants of this convergence consisting of foreign direct investment (FDI), export, and import. By using Stochastic Frontier Analysis to estimate technical efficiency as well as panel dynamic of Generalized Methods of Moment (GMM) to test convergence, we found robust findings of convergence moments, both the catching up effect (Beta Convergence) as well as inequality reduction (Sigma Convergence) across the countries. The effect of FDI inflow to the growth of technical efficiency growth is positive. Coupled to this, a higher ratio of export to the GDP affects positively to the efficiency growth by about 14%-26%. In contrast, importing causes diminishing efficiency growth. The effect of FDI is significant in reducing the inequalities of efficiency only in the period of 2006-2021. While export reveals positive significance in affecting efficiency gap, import discourages efficiency gap to enlarge, indicating that import substitution remains unable to be implemented in some countries to obtain efficiency.
APPRAISAL OF THE EMPOWERMENT AND TRAINING PROGRAM IN ACHIEVEING ZAKAT AMIL PERFORMANCE THROUGH ISLAMIC JOB SATISFACTION
Authors: Munifatussaidah Asma , Prasetyo Ari
Published: December 2023

Empowerment and training program become a new technique that makes employees proactive in improving their performance. Thus, this research purpose to observe the appraisal of the Employee Empowerment and Training programs of zakat in achieving Employee zakat (Amil) Performance by mediating Islamic Job Satisfaction at the Zakat Institution (LAZNAS) in Central Java. This research used quantitative method with a survey approach. The research sample was 180 Amil at 12 LAZNAS in Central Java, who served in the collection, distribution, and utilization of zakat with a minimum service period of two years, and had received training about zakat management. The research sample was selected through the purposive sampling technique and analyzed with the Partial Least Square (SEM-PLS). The research findings indicate that the variables Employee Empowerment and Training programs have an effect toward Islamic Job Satisfaction. Then there is the direct and indirect effect of the Training programs toward the AmilPerformance at the Zakat Institution (LAZNAS) in Central Java with the mediation of Islamic Job Satisfaction. Meanwhile, for the effect of the Employee Empowerment toward Amil Performance, there is no significant in direct effect. However, there is an indirect effect of the Employee Empowerment toward  Amil Performance at the Zakat Institution (LAZNAS) in Central Java with the mediating Islamic Job Satisfaction. This research was expected to be of particular concern to zakat institutions, especially in the human resources section to help provide information regarding the importance of empowering and training program for Amil performance in Zakat Institutions (LAZNAS) to improve collecting, distributing and utilizing zakat.
DOES THE COMMUNITY'S PERSPECTIVE ENCOURAGE CUSTOMERS TO TAKE FINANCING PRODUCTS AT SHARIA BANK?
Authors: Muharromah Syahriyatul , Huda Nurul , Muslikh Muslikh , Rini Nova
Published: December 2023

This study aims to determine community interest in financing products at Islamic banks with a modified Theory Planned Behavior (TPB) approach. These modified TPB variables consist of knowledge, religiosity, attitudes, subjective norms and behavioural control. This research was conducted in Jakarta. Islamic banks located in the Jakarta area are the object of this research, and the sample is 130 respondents. The quantitative method with the Partial Least Square (PLS) analysis model approach with SmartPLS 2.0 software is the method used in this study. The variables of knowledge, religiosity, attitudes, subjective norms and behavioural control are exogenous, while the intervening variable is community interest, and the endogenous variable is financing decisions. The variables of knowledge, religiosity, attitudes, subjective norms and behavioral control, which have a direct positive and significant effect on the community's interest in using Islamic bank financing products, are the results of this study. Knowledge, Attitude and behavioural control directly and significantly positive affect the community's decisions to choose financing products in Islamic banks. The higher people's knowledge, Attitude and behavioural control, the higher the financing decision becomes the implications of this research result. Religiosity and  subjective norms significantly negatively affect the decision to choose financing products in Islamic banks. In addition, community interest also has a positive and significant effect on financing decisions. This means that, community interest can significantly mediate knowledge, religiosity, subjective norms, attitudes, and behavioral control influence financing decisions. Based on the research results, Indonesian Islamic Banks can develop business by emphasizing the religiosity side to inspire people to prefer financing of Islamic banks over conventional banks. Furthermore, Bank Syariah Indonesia should use social-environmental reference factors like friends, family, neighbors and religious figures
APPLICATION OF RATION FORMULATION BASED ON AGRICULTURAL WASTE AS GOAT COMPLETE FEEDING IN KALIMPORO VILLAGE, JENEPONTO REGENCY
Authors: Purba Fika Yuliza , Muhammad Ardiansyah Nurdin  , Nur Alif Bahmid  , Muhammad Ihsan Andi Dagong  , Renny Fatmyah Utamy  , Irwan Ismail  , Soedarmanto Indarjulianto  , Subaedy Yusuf
Published: December 2023

This community service was carried out in Kalimporo Village, Jeneponto Regency, South Sulawesi, and aimed to increase farmers' knowledge, especially the Kalimporo Village farmers group, regarding the utilization and processing of agricultural waste into complete feed for livestock. Community Service was held on Sunday, 4th June 2023 in Kalimporo Village, Jeneponto Regency, South Sulawesi, attended by 25 out of 30 farmers (83.3%). The method used was discourse and plot demonstration. The results of this community service were the use of several types of agricultural waste such as bran, green bean skin, corn cobs, lamtoro, cassava, copra meal, and pollard available around the village to be formulated into complete feed with added minerals and salt. The ration was tested in the laboratory and showed good quality with a crude protein content of 12.13%. The feed was highly palatable when given to the goats. Ration based on agricultural waste can be used as a complete feed for goats with economic value so as to reduce livestock production costs and improve the farmers' well-being in Kalimporo Village, Jeneponto Regency, South Sulawesi.