bluuebunny/crossref_metadata_2025 huggingface dataset:
Aqueous‐Phase Amination of Biogenic Isohexides by using Ru/C as a Solid Catalyst
Authors: Pfützenreuter Rebecca , Rose Marcus
Published: November 2015

An aqueous phase process for the amination of biogenic isohexides with ammonia using Ru/C as solid catalyst is reported. The products possess great potential for the production of biogenic polyamides. From the diol substrates amino alcohols and diamines are derived as main products with significantly varying product selectivity depending on the substrates’ stereochemistry. The catalytic reaction is performed at temperatures of 140–180 °C. The Ru/C catalyst shows a high activity in the aqueous phase, which is beneficial for the transformation of the polar biogenic substrates. Despite the basic conditions, the metal leaching is negligible and the catalyst can be recycled easily in batch operation and, thus, enables further process development thanks to the mild and scalable reaction conditions.
An Experimental and Theoretical Investigation on Pentacoordinated Cobalt(III) Complexes with an Intermediate S=1 Spin State: How Halide Ligands Affect their Magnetic Anisotropy
Authors: Brazzolotto Deborah , Gennari Marcello , Yu Shengying , Pécaut Jacques , Rouzières Mathieu , Clérac Rodolphe , Orio Maylis , Duboc Carole
Published: November 2015

Understanding the factors that control the magnitude and symmetry of magnetic anisotropy should facilitate the rational design of mononuclear metal complexes in the quest for single‐molecule magnets (SMMs), based on a single metal ion, with high blocking temperatures and large energy barriers. The best strategy is to define magnetostructural correlations through the investigation of a series of metal complexes. It has been demonstrated that the main contribution to the magnetic anisotropy arises from the spin‐orbit coupling (SOC) effect in metal‐ion‐based systems, so current studies focus particularly on the use of both ligands and metal ions possessing a large SOC. In this context, we report a unique series of halide CoIII complexes, [CoL(X)], with X=Cl, Br, I (CoX) and L=2,2′‐(2,2′‐bipyridine‐6,6′‐diyl)bis(1,1‐diphenylethanethiolate), which possess a rare intermediate S=1 spin ground state. The S=1 CoIII complexes are attractive species because they possess a remarkably large axial zero‐field splitting (defined by D from the following Hamiltonian: H=DSz2), as well as the halide ligands inducing large SOC constants. The single‐crystal X‐ray structures reveal that the CoBr and CoI complexes are isostructural with the previously described CoCl complex. Their coordination sphere displays a distorted pentacoordinated square pyramidal geometry, with the halide located in the CoIII axial position. Large positive D values of 35, 26, and 18 cm−1 are found for CoCl, CoBr, and CoI, respectively, through analysis of the magnetic susceptibility data as a function of temperature. To rationalize this trend, theoretical calculations based on both density functional theory (DFT) and complete active space self‐consistent field (CASSCF) methods are performed successfully. Both the sign and magnitude of D are predicted remarkably well by these theoretical approaches. The DFT calculations also show that the resulting D values originate from a balance of several contributions, and that many factors, including differences in their structural properties and in the contribution of the halide, should be taken into account to explain the trend of D in this series of complexes.
The Resurgence of the Highly Ylidic N‐Heterocyclic Olefins as a New Class of Organocatalysts
Authors: Crocker Reece D. , Nguyen Thanh V.
Published: November 2015

In recent decades, N‐heterocyclic carbenes have become established as a prevalent family of organocatalysts. N‐Heterocyclic olefins, the alkylidene derivatives of N‐heterocyclic carbenes, have recently also emerged as efficient promoters for CO2 fixation and polymerization reactions. Their extraordinarily strong Lewis/Brønsted basicity suggests great potential as a new class of organocatalysts for a broad range of reactions in synthetic chemistry.
ChemInform Abstract: On Squaring Triangles — Structural Motifs in Cu—In—Sb Compounds.
Authors: Mueller C. J. , Lidin S.
Published: November 2015

Two new compounds, Cu7In2.5Sb0.5 (I) and Cu2In0.75Sb0.25 (II) are prepared from the elements (silica ampules, 1173 K, 3 d, followed by annealing at 573—773 K for 220 d).
ChemInform Abstract: RbMgCO3F: A New Beryllium‐Free Deep‐Ultraviolet Nonlinear Optical Material.
Authors: Tran T. Thao , He Jiangang , Rondinelli James M. , Halasyamani P. Shiv
Published: November 2015

Polycrystalline RbMgCO3F is prepared by solid state reaction of a stoichiometric mixture of RbF and MgCO3 (alumina boat, 330 °C, 5 d).
ChemInform Abstract: Photoluminescence Properties and Thermal Stability of Eu2+ and Mn2+ Co‐Doped BaSi3O4N2 Phosphors.
Authors: Huang DeCai , Zhou YouFu , Xu WenTao , Wang Kun , Liu Zhuguang , Hong MaoChun
Published: November 2015

Ba0.94‐xEu0.06MnxSi3O4 N2 (x = 0‐0.1) phosphors are prepared by solid state reaction of stoichiometric amounts of BaCO3, α‐Si3N4, SiO2, MnCO3, and Eu2O3 under reducing atmosphere (10% H2/N2, BN crucible, 1350 °C, 4 h).
ChemInform Abstract: Synthesis and Luminescence Properties of RE3+ (RE: Yb, Er, Tm, Eu, Tb)‐Doped Sc2O3 Microcrystals.
Authors: Li Daguang , Qin Weiping , Liu Shihu , Pei Wenbo , Wang Zhe , Zhang Peng , Wang Lili , Huang Ling
Published: November 2015

In a typical synthesis, Sc2O3:10 mol% Tb, 2 mol% Er microcrystals with controllable morphology and luminescence are prepared by adding aqueous urea to an aqueous solution of Sc, Yb, and Er nitrates plus ethylene glycol (85 °C, 4 h).
ChemInform Abstract: Luminescent Properties of Bi3+‐Activated Ca2Sb2O7 Nano‐Phosphor Prepared by Co‐Precipitation Method.
Authors: Yao Shiyue , Zhou Xuan , Huang Yanling , Wang Zuoshan , Long Yumei , Li Weifeng
Published: November 2015

A series of Ca2Sb2O7:xBi3+ (x = 0‐8 mol%) blue phosphors is prepared by co‐precipitation from a dilute HCl solution of Bi2O3, Sb2O3, and aqueous CaCl2 by adding a NaOH/Na2C2O4 solution.
ChemInform Abstract: Giant Magnetoresistance in the Half‐Metallic Double‐Perovskite Ferrimagnet Mn2FeReO6.
Authors: Greenblatt Martha , et al.
Published: November 2015

Polycrystalline Mn2+2Fe3+Re5+O6 is prepared by hot pressing of a stoichiometric mixture of MnO, Fe2O3, and ReO3 (multianvil press, 5 GPa, 1623 K, 1 h; decompression within 8‐12 h).
ChemInform Abstract: HgI2: A Novel Photocatalyst with High Performance in Degradation of Rhodamine B Dyes under Visible‐Light Irradiation.
Authors: Tang Jianting , Li Datang , Feng Zhaoxia , Long Chengyun
Published: November 2015

HgI2 is precipitated from an aqueous solution of Hg(NO3)2, KI, and NH3 in the molar ratio of 1:2:2, respectively.
ChemInform Abstract: Scandium Functionalized Carbon Aerogel: Synthesis of Nanoparticles and Structure of a New ScOCl and Properties of NaAlH4 as a Function of Pore Size.
Authors: Javadian Payam , Nielsen Thomas K. , Ravnsbaek Dorthe B. , Jepsen Lars H. , Polanski Marek , Plocinski Tomasz , Kunce Izabela , Besenbacher Flemming , Bystrzycki Jerzy , Jensen Torben R.
Published: November 2015

Scandium is infiltrated into nanoporous carbon aerogels by submerging the aerogels into aqueous solutions of ScCl3 (465 °C, 12 h) forming nanoconfined [Sc(OH)(H2O)5] 2Cl4(H2O)2, which transforms to nanoparticles of the new compound ScOCl at 192 °C and to Sc2O3 at 420 °C.
ChemInform Abstract: Synthesis, Crystal Structure, Optical, and Electronic Study of the New Ternary Thorium Selenide Ba3ThSe3(Se2)2.
Authors: Prakash Jai , Mesbah Adel , Beard Jessica , Lebegue Sebastien , Malliakas Christos D. , Ibers James A.
Published: November 2015

Dark‐red block‐shaped crystals of the new title compound are synthesized by solid state reaction of stoichiometric amounts of the elements (silica tubes, 1033 K, 15 h, annealing at 1173 K for 96 h, 20 wt.% yield).
ChemInform Abstract: Synthesis, Crystal Structure and Ionic Conductivity of a New Open‐Framework Arsenate K0.405Bi0.865AsO4.
Authors: Falah Chiraz , Ben Smida Youssef , Ledoux‐Rak Isabelle , Boughzala Habib
Published: November 2015

K0.405Bi0.865AsO4 is prepared via solid state reaction of a 3:3:4 = K:Bi:As molar mixture of K2CO3, Bi2O3, and NH4H2AsO4 (850 °C, 1 month; cooling to 25 °C at a rate of 5 K/h).
ChemInform Abstract: Iridium/Copper‐Cocatalyzed Asymmetric Ring Opening Reaction of Azabenzonorbornadienes with Amines.
Authors: Zeng Chaoyuan , Yang Fan , Chen Jingchao , Wang Jun , Fan Baomin
Published: November 2015

The title reaction affords chiral trans‐vicinal diamines (III) and (V) in high yields and excellent enantioselectivities.
ChemInform Abstract: Unique Features of Chiral Palladium Enolates Derived from β‐Ketoamide: Structure and Catalytic Asymmetric Michael and Fluorination Reactions.
Authors: Hayamizu Kenji , Terayama Naoki , Hashizume Daisuke , Dodo Kosuke , Sodeoka Mikiko
Published: November 2015

Chiral Pd‐BINAP complexes catalyze enantioselective Michael and fluorination reactions of β‐ketoamides and β‐ketoesters in which Pd‐enolate intermediates play a key role.
ChemInform Abstract: Simple Route to Multisubstituted Tetrahydropyrimidines.
Authors: Vincze Zoltan , Pilipecz Mihaly V. , Scheiber Pal , Varga Tamas R. , Toth Gabor , Nemes Peter
Published: November 2015

Nitroenamines (I), (VI), and (VIII) serve as key intermediates in the synthesis of pyrrolopyrimidines (III), pyrimidines (IX) and dihydropyrrolones (XI).
ChemInform Abstract: Smaller, Faster, Better: Modular Synthesis of Unsymmetrical Ammonium Salt‐Tagged NHC—Gold(I) Complexes and Their Application as Recyclable Catalysts in Water.
Authors: Belger Katrin , Krause Norbert
Published: November 2015

The title catalysts are applied in the cyclization reaction of acetylenic carboxylic acids and amides (I), (V) and (III) to lactones (II), (VI), and lactams (IV), respectively.
ChemInform Abstract: Silver‐Catalyzed Coupling of Two C(sp3)—H Groups and One‐Pot Synthesis of Tetrasubstituted Furans, Thiophenes, and Pyrroles.
Authors: Mao Shuai , Zhu Xue‐Qing , Gao Ya‐Ru , Guo Dong‐Dong , Wang Yong‐Qiang
Published: November 2015

A silver catalyzed coupling reaction using air as the terminal oxidant is developed for the synthesis of 1,4‐diketones.
ChemInform Abstract: Aerobic Oxidation of Hydroxylamines with Nanoporous Gold Catalyst as an Efficient Synthetic Method of Nitrones.
Authors: Yudha S Salprima , Kusuma Indra , Asao Naoki
Published: November 2015

The gold catalyst is reused several times without leaching of gold.
ChemInform Abstract: Mild and Efficient Cobalt‐Catalyzed Cross‐Coupling of Aliphatic Amides and Aryl Iodides in Water.
Authors: Tan Bryan Yong‐Hao , Teo Yong‐Chua
Published: November 2015

Pyrrolidinone (I) and aliphatic amides (IV) can be arylated by the cobalt oxalate‐mediated reaction with aryl iodides.
ChemInform Abstract: Recyclable Palladium Catalyst on Grapheme Oxide for the C—C/C—N Cross‐Coupling Reactions of Heteroaromatic Sulfonates.
Authors: Yang Quanlu , Quan Zhengjun , Wu Shang , Du Baoxin , Wang Mingming , Li Peidong , Zhang Yinpan , Wang Xicun
Published: November 2015

The catalyst is recyclable and reusable at least 5 times (Suzuki coupling).
ChemInform Abstract: Metal‐Free Synthesis of Ynones via Direct C—H Alkynylation of Aldehydes with Ethynylbenziodoxolones.
Authors: Zhang Ruo‐Yi , Xi Long‐Yi , Zhang Lei , Chen Shan‐Yong , Yu Xiao‐Qi
Published: November 2015

Under prolonged reaction time, benzyl alcohols (VIII) can also be converted into ynones though in modest yields only.
ChemInform Abstract: Catalytic meta‐Selective C—H Functionalization to Construct Quaternary Carbon Centres.
Authors: Paterson Andrew J. , St John‐Campbell Sahra , Mahon Mary F. , Press Neil J. , Frost Christopher G.
Published: November 2015

A regioselective C—H functionalization of 2‐phenylpyridines (I) is developed using a range of tertiary halides (II) and (IV) to afford challenging quaternary carbon centers.
ChemInform Abstract: Palladium‐Catalyzed Mono‐α‐arylation of Acetone at Room Temperature.
Authors: MacQueen Preston M. , Chisholm Alicia J. , Hargreaves Breanna K. V. , Stradiotto Mark
Published: November 2015

A catalyst system consisting of [Pd(cinnamyl)Cl]2 and JosiPhos is found to enable the first mono‐α‐arylation of acetone using a variety of aryl halides.
ChemInform Abstract: Phosphine‐Free Suzuki Cross‐Coupling Reaction Using an Efficient and Reusable Pd Catalyst in an Aqueous Medium under Microwave Irradiation.
Authors: da Silva Joaquim F. M. , Yepes Perez Andres F. , de Almeida Natalia P.
Published: November 2015

Various functionalized biaryls, (hetaryl)aryls, (hetaryl)pyridines, and allylphenols are efficiently and ecofriendly synthesized.
ChemInform Abstract: Zirconium‐Catalyzed Direct Amide Bond Formation Between Carboxylic Esters and Amines.
Authors: Lenstra Danny C. , Nguyen D. Thao , Mecinovic Jasmin
Published: November 2015

Amidation of aliphatic or aromatic carboxylic esters with primary and secondary amines is accomplished in the presence of zirconocene dichloride as catalyst.
ChemInform Abstract: Facile Construction of 3‐Indolochromenes and 3‐Indoloxanthenes via EDDF Catalyzed One‐Pot Three Component Reactions.
Authors: Thakur Anuj , Linga Reddy P. , Tripathi Mohit , Rawat Diwan S.
Published: November 2015

The advantages of the title synthesis are short reaction time, high yields, easy work‐up, and recyclability of the catalyst.
ChemInform Abstract: A Novel Nickel‐Catalyzed Synthesis of Thioesters, Esters and Amides from Aryl Iodides in the Presence of Chromium Hexacarbonyl.
Authors: Iranpoor Nasser , Firouzabadi Habib , Etemadi‐Davan Elham , Nematollahi Arash , Firouzi Hamid Reza
Published: November 2015

The title synthesis uses Cr(CO)6 as the solid source of CO under ligand‐free and mild reaction conditions.
ChemInform Abstract: Michael Addition Initiated Substrate‐ or Catalyst‐Controlled Chemodivergent Three‐Component Construction of Fused and Bridged Polycyclic Heterocycles.
Authors: Du Haiying , Rodriguez Jean , Bugaut Xavier , Constantieux Thierry
Published: November 2015

The three‐component reaction of β‐keto esters, enals, and amines affords two different types of products depending on the presence of a substituent in the α‐position of the aldehyde.
ChemInform Abstract: Novel One‐Pot Synthetic Method for Propargyl Alcohol Derivatives from Allyl Alcohol Derivatives.
Authors: Kutsumura Noriki , Inagaki Mai , Kiriseko Akito , Saito Takao
Published: November 2015

Bromination of allyl alcohol derivatives [e.g. (I)] gives 1,2‐dibromoalkanes, which undergo double trans‐HBr elimination, promoted by Bu4NOH, to give the propargyl alcohols [e.g. (II)].
ChemInform Abstract: Copper‐Mediated Oxidative Difluoromethylation of Terminal Alkynes with TMSCF2H.
Authors: Zhu Sheng‐Qing , Xu Xiu‐Hua , Qing Feng‐Ling
Published: November 2015

Difluoromethylated alkynes are prepared by difluoromethylation of terminal akynes using 9,10—phenanthraquinone as oxidant.
ChemInform Abstract: Synthesis of (Diarylmethyl)amines Using Ni‐Catalyzed Arylation of C(sp3)—H Bonds.
Authors: Fernandez‐Salas Jose A. , Marelli Enrico , Nolan Steven P.
Published: November 2015

The first nickel catalyzed deprotonative cross coupling of imines with aryl chlorides in the absence of a directing group is reported.
ChemInform Abstract: Polyethyleneimine‐Supported Triphenylphosphine and Its Use as a Highly Loaded Bifunctional Polymeric Reagent in Chromatography‐Free One‐Pot Wittig Reactions.
Authors: Xia Xuanshu , Toy Patrick H.
Published: November 2015

A polymer‐supported phosphine reagent is used in one‐pot Wittig reactions.
ChemInform Abstract: Cyclopropanation of (E)‐Dehydroaspartic Acid Esters with Furan Derivatives: The Synthesis of Highly Functionalized α‐2,3‐Methanoamino Acid Esters.
Authors: Manabe Atsushi , Matsumoto Ryotaro , Shinada Tetsuro
Published: November 2015

7 Cyclopropane derivatives of type (III) are prepared by the reaction of N‐protected dehydroaspartic acid esters (I) with 3‐substituted silyloxyfuran derivatives; only one stereoisomer is selectively formed.
ChemInform Abstract: Rh‐Catalyzed Desymmetrization of α‐Quaternary Centers by Isomerization‐Hydroacylation.
Authors: Park Jung‐Woo , Kou Kevin G. M. , Kim Daniel K. , Dong Vy M.
Published: November 2015

A new Rh‐catalyzed desymmetrization of all‐carbon quaternary centers from α,α‐bis(allyl)aldehydes by a cascade featuring isomerization and hydroacylation is reported.
ChemInform Abstract: Cascade Rearrangement of Furylcarbinols with Hydroxylamines: Practical Access to Densely Functionalized Cyclopentane Derivatives.
Authors: Veits Gesine K. , Wenz Donald R. , Palmer Leoni I. , St. Amant Andre H. , Hein Jason E. , Read de Alaniz Javier
Published: November 2015

A novel synthesis of hydroxylamine‐substituted cyclopentenones via aza‐Piancatelli rearrangement of furylcarbinols with hydroxylamines is reported.
ChemInform Abstract: High‐Yield Lithiation of Azobenzenes by Tin—Lithium Exchange.
Authors: Strueben Jan , Lipfert Matthias , Springer Jan‐Ole , Gould Colin A. , Gates Paul J. , Soennichsen Frank D. , Staubitz Anne
Published: November 2015

Transmetalation of Me3Sn‐substituted azobenzenes with MeLi results in a rapid and selective Li‐Sn exchange.
ChemInform Abstract: Synthesis of Acyl Alkenylindium Reagents and Their Application in the Synthesis of (Z)‐α,β‐Unsaturated Ketones via Palladium‐Catalyzed Cross‐Coupling Reaction.
Authors: Park Youngchul , Min Jiae , Eom Dahan , Lee Phil Ho
Published: November 2015

Hydroindation reaction of allenyl ketones with indium and indium chloride produces indium reagents (II), which undergo Pd‐catalyzed cross‐coupling reactions with aryl iodides, bromides, and triflates as well as cyclohexenyl triflates to form (Z)‐α,β‐unsaturated ketones predominantly.
ChemInform Abstract: Undecorated Cu(OAc)2‐Catalyzed C(sp3)—C(sp3) Bond Formation Through para‐Hydroxy Group Triggered Remote Benzylic C(sp3)—H Bond Functionalization.
Authors: Huang Jian‐Gang , Guo Ying , Li Yu‐Dan , Liu Hong‐Wei , Liao Dao‐Hua , Ji Ya‐Fei
Published: November 2015

Highly functionalized 3‐arylpropanoate derivatives containing a fluorinated quaternary carbon center are rapidly and ecofriendly obtained by oxidative coupling of 2,6‐disubstituted 4‐cresols with fluorinated β‐ketoesters or malonates using ambient air as the terminal oxidant.
ChemInform Abstract: Palladium(II)‐Catalyzed Sequential ortho‐Olefination of β‐Arylethamines with Assistance of Oxalyl Amide.
Authors: Liu Pei , Han Jian , Wang Qian , Huang Zhibin , Shi Daqing , Zeng Runsheng , Zhao Ying Sheng
Published: November 2015

The title reaction tolerates a wide range of functional groups.
ChemInform Abstract: Preparation of Conjugated Dienoates with Bestmann Ylide: Towards the Synthesis of Zampanolide and Dactylolide Using a Facile Linchpin Approach.
Authors: Wang Jingjing , Ting Samuel Z Y , Harvey Joanne E
Published: November 2015

The Bestmann ylide (III) is used as a linking entity between C3‐C8 aldehyde and C16‐C20 alcohol fragments to synthesize unsaturated esters.
ChemInform Abstract: One‐Pot Synthesis of Allylic Sulfones, Ketosulfones, and Triflyl Allylic Alcohols from Domino Reactions of Allylic Alcohols with Sulfinic Acid under Metal‐Free Conditions.
Authors: Chu Xue‐Qiang , Meng Hua , Xu Xiao‐Ping , Ji Shun‐Jun
Published: November 2015

Sulfonylation of alcohols (I) provides allylic sulfones, which undergo an oxidative functionalization to yield ketosulfones (IV) and (X) or triflyl allylic alcohols (VII).
ChemInform Abstract: Palladium‐Catalyzed C(sp3)—H Arylation of N‐Boc Benzylalkylamines via a Deprotonative Cross‐Coupling Process.
Authors: Hussain Nusrah , Kim Byeong‐Seon , Walsh Patrick J.
Published: November 2015

The first direct α‐arylation of N‐Boc benzylalkylamines is developed using aryl halides or triflate as electrophiles in the presence of a Pd/NiXantPhos catalyst system.
ChemInform Abstract: Regioselective Synthesis of Fullerene Multiadducts via Tether‐Directed 1,3‐Dipolar Cycloaddition.
Authors: Zhang Bolong , White Jonathan M. , Jones David J. , Wong Wallace W. H.
Published: November 2015

The regioselective synthesis of fullerene multiadducts is achieved from commercially available reagents in one pot over two steps.
ChemInform Abstract: Convenient Synthesis of Spiroindole Derivatives via Palladium‐Catalyzed Cyclization of Propargyl Chlorides.
Authors: Iwata Akira , Inuki Shinsuke , Oishi Shinya , Fujii Nobutaka , Ohno Hiroaki
Published: November 2015

The cyclization of propargyl chlorides (I) in the presence of benzylamine affords spiroindoles (II), whereas in the presence of sulfonamide (III) and malonate (V) spiroindoles (IV) or (VI) are predominantly formed.
ChemInform Abstract: Chiral‐Squaramide‐Catalyzed Sulfa‐Michael/Aldol Cascade Reactions for Asymmetric Synthesis of Spirothiochromanones.
Authors: Zhao Bo‐Liang , Du Da‐Ming
Published: November 2015

Optimized reaction conditions are developed for the reaction of arylidenecycloketones with aldehyde (II) to give spirothiochromanones in high yields, diastereo‐ and enantioselectivities.
ChemInform Abstract: Improved Synthetic Utility of a Sluggish Electrophile: Reaction of Chlorosulfonyl Isocyanate with Unreactive and Reactive Alkenes.
Authors: Shellhamer Dale F. , Alexander Kelsey L. , Bunting Summer A. , Elwin Sarah L. , Licata Christine J. , Milligan Jacob C. , Robinson RyanD. , Shipowick Danielle E. , Smith Lincoln B. , Perry Marc C.
Published: November 2015

The equilibrium between two separate reactants and a complex or SET intermediate formed by them shifts towards the unimolecular intermediate between ‐15 and 25°, therefore, the efficiency of the electrophile (II) is improved under the reaction conditions.
ChemInform Abstract: Diethylene Glycol Serving as Ethyne Equivalent: A Sustainable Approach Toward 2,3‐Disubstituted Furan.
Authors: Yu Jin‐Tao , Shi Bo , Peng Haibo , Sun Song , Chu Haoke , Jiang Yan , Cheng Jiang
Published: November 2015

A copper‐catalyzed annulation of ethylene glycol with various 1,3‐dicarbonyl compounds, including (hetero)arylacetoacetic esters, amides, ketones, and thioesters is elaborated which provides 2,3‐disubstituted furans, mostly regioselectively, in moderate to high yields.
ChemInform Abstract: Synthesis of Substituted 3‐Methylene‐2,3‐dihydrobenzofurans and 3‐Methylbenzofurans by Rhodium (II)‐Catalyzed Annulation.
Authors: Chen Ying‐Yu , Chen Kuan‐Lin , Tyan Yu‐Chang , Liang Chien‐Fu , Lin Po‐Chiao
Published: November 2015

Depending on the reaction temperature either the 3‐methylene‐2,3‐dihydrobenzofurans or the 3‐methylbenzofurans are obtained.
ChemInform Abstract: Copper‐Catalyzed Oxidative C—H/C—H Cross‐Coupling of Benzamides and Thiophenes.
Authors: Zhao Sheng , Yuan Jun , Li Yi‐Chen , Shi Bing‐Feng
Published: November 2015

The title reaction uses an excess of AgNO3 as an oxidant.
ChemInform Abstract: Oxalyl Amide Assisted Palladium‐Catalyzed Synthesis of Pyrrolidones via Carbonylation of γ‐C(sp3)—H Bonds of Aliphatic Amine Substrates.
Authors: Wang Chao , Zhang Li , Chen Changpeng , Han Jian , Yao Yingming , Zhao Yingsheng
Published: November 2015

The first Pd‐catalyzed regioselective γ‐carbonylation of oxalyl amide protected aliphatic amines with carbon monoxide results in the formation of pyrrolidones.
ChemInform Abstract: Acid‐Catalyzed Cascade Radical Addition/Cyclization of Arylacrylamides with Ketones.
Authors: Xia Xiao‐Feng , Zhu Su‐Li , Zeng Minglu , Gu Zhen , Wang Haijun , Li Wei
Published: November 2015

N‐arylacrylamides, phenyl methacrylate as well as pentane‐2,4‐dione and ethyl acetoacetate do not react.
ChemInform Abstract: Ligand‐Enabled Ir‐Catalyzed Intermolecular Diastereoselective and Enantioselective Allylic Alkylation of 3‐Substituted Indoles.
Authors: Zhang Xiao , Liu Wen‐Bo , Tu Hang‐Fei , You Shu‐Li
Published: November 2015

An Ir‐catalyzed asymmetric allylic alkylation of 3‐substituted indoles is reported.
ChemInform Abstract: Gadolinium(III) Chloride Catalyzed Facile Synthesis of 2‐Substituted Benzimidazoles under Solvent‐Free Conditions
Authors: Sathaiah G. , Lingaiah B. P. Venkat , Shekhar A. Chandra , Kumar A. Ravi , Raju K. , Rao P. Shanthan
Published: November 2015

starting from o‐diamines and 1,3‐dicarbonyl compounds
ChemInform Abstract: Synthesis of 3‐Oxazolines via SnCl4‐Promoted Formal [3 + 2] Cycloaddition of Donor—Acceptor Oxiranes and Nitriles.
Authors: Zhou Hai , Zeng Xiaofei , Xie Yan , Zhong Guofu
Published: November 2015

22 Title compounds (III) are prepared by the reaction of oxiranes (I) with nitriles (II).
ChemInform Abstract: One‐Pot Three‐Component Synthesis of 1,2,3‐Triazoles Using Magnetic NiFe2O4—Glutamate—Cu as an Efficient Heterogeneous Catalyst in Water.
Authors: Lu Jun , Ma Er‐Qian , Liu Yu‐Heng , Li Ya‐Meng , Mo Li‐Ping , Zhang Zhan‐Hui
Published: November 2015

The triazoles are synthesized from sodium azide, non‐activated terminal alkynes, different azide precursors such as epoxides, benzyl chlorides, and aryl boronic acids at room temperature in water in high yields with wide substrate scopes.
ChemInform Abstract: Reactivity of 1,2,3‐Triazoles Towards Sulfonyl Chlorides. A Novel Approach to 1‐ and 2‐Sulfonyl‐4‐azolyl‐1,2,3‐triazoles.
Authors: Beryozkina Tetyana V. , et al.
Published: November 2015

The regioselectivity of the sulfonylation is mainly influenced by the nature of the aryl substituent at C‐4 and the bulkiness of the sulfonyl chloride.
ChemInform Abstract: Asymmetric Michael Addition/Intramolecular Cyclization Catalyzed by Bifunctional Tertiary Amine‐Squaramides: Construction of Chiral 2‐Amino‐4H‐chromene‐3‐carbonitrile Derivatives.
Authors: Gao Yu , Du Da‐Ming
Published: November 2015

The efficient asymmetric Michael addition/intramolecular cyclization of malononitrile with dienones catalyzed by a chiral bifunctional tertiary amine—squaramide catalyst for the synthesis of chiral 2‐amino‐4H‐chromene‐3‐carbonitrile derivatives is developed.
ChemInform Abstract: Synthetic and Structural Studies on Novel 4,3′‐Bicoumarins.
Authors: Pujar Kiran K. , Kulkarni Manohar V. , Alawandi Ganesh N. , Anilkumar G. N. , Basanagouda Mahantesha
Published: November 2015

The title coumarins are conveniently obtained by two methods either in the presence of piperidine or of sodium hydride.
ChemInform Abstract: Mild and Regioselective N‐Alkylation of 2‐Pyridones in Water.
Authors: Hao Xin , Xu Zhongmiao , Lu Hongfu , Dai Xuedong , Yang Ting , Lin Xichen , Ren Feng
Published: November 2015

Tween 20 is used to create a micellar system in the title reaction.
ChemInform Abstract: One‐Pot Synthesis of Quinolin‐4(1H)‐one Derivatives by a Sequential Michael Addition—Elimination/Palladium‐Catalyzed Buchwald—Hartwig Amination Reaction.
Authors: Wang Yinghua , Liang Hanyu , Chen Chunxia , Wang Deqiang , Peng Jinsong
Published: November 2015

The title synthesis uses chlorovinyl aromatic ketones [e.g. (I)] or bromovinyl aromatic ketones [e.g. (XIV)] and amines as starting material and the products can be obtained in good to excellent yields.
ChemInform Abstract: Coupling Cyclizations with Fragmentations for the Preparation of Heteroaromatics: Quinolines from O‐Alkenyl Arylisocyanides and Boronic Acids.
Authors: Evoniuk Christopher J. , Ly Michelle , Alabugin Igor V.
Published: November 2015

Stereoelectronic restrictions on homoallylic ring expansion in alkyne cascades can be overcome by use of alkenes as synthetic equivalents of alkynes in reaction cascades that are terminated by C—C bond fragmentation.
ChemInform Abstract: Graphene Oxide Nanosheets: A Highly Efficient and Reusable Carbocatalyst Catalyzes the Michael‐Cyclization Reactions of 4‐Hydroxycoumarins, 4‐Hydroxypyrone and 4‐Hydroxy‐1‐methylquinolinone with Chalcone Derivatives in Aqueous Media.
Authors: Kausar Nazia , Ghosh Partha Pratim , Pal Gargi , Das Asish R.
Published: November 2015

A library of pyranoquinolines, pyranopyrans and 4H‐pyrans are synthesized from the title methods.
ChemInform Abstract: Ruthenium‐Catalyzed Oxidative C—H Bond Alkenylation of 2‐Phenylimidazo[1,2‐a]pyridine.
Authors: Sawant Devesh , Singh Iqubal , Tulsyan Gaurav , Abbagani Kishor , Pardasani Ram T.
Published: November 2015

The ruthenium‐catalyzed oxidative C—H bond alkenylation of 2‐phenylimidazo[1,2‐a]pyridine (I) with acrylates (II) affords regioselectively the corresponding ortho products (III).
ChemInform Abstract: Modular, Concise, and Efficient Synthesis of Highly Functionalized 5‐Fluoropyridazines by a [2 + 1]/[3 + 2]‐Cycloaddition Sequence.
Authors: Tran Gael , Gomez Pardo Domingo , Tsuchiya Tomoki , Hillebrand Stefan , Vors Jean‐Pierre , Cossy Janine
Published: November 2015

The [2+1] reaction of terminal alkynes [e.g. (I)] and difluorocarbene ([II] or [IX]) gives difluorocyclopropenes [e.g. (III)] which further go through [3 + 2]‐cycloaddition with diazo compounds [e.g. (IV)] to furnish fluoropyridazines [e.g. (VI)].
ChemInform Abstract: Substrate Directed C—H Activation for the Synthesis of Benzo[c]cinnolines Through a Sequential C—C and C—N Bond Formation.
Authors: Reddy B. V. Subba , Reddy C. Ravikumar , Reddy M. Rajashekhar , Yarlagadda Suresh , Sridhar B.
Published: November 2015

The novel strategy is based on an oxidative two‐step transformation of hydrazine dicarboxylates with aryl iodides.
ChemInform Abstract: C—C/C—N Cross‐Coupling Reactions of Aryl Sulfonates Catalyzed by an Eco‐Friendly and Reusable Heterogeneous Catalyst: Wool—Pd Complex.
Authors: Yang Quan‐Lu , Quan Zheng‐Jun , Du Bao‐Xin , Wu Shang , Zhang Yin‐Pan , Li Pei‐Dong , Wang Ming‐Ming , Lei Zi‐Qiang , Wang Xi‐Cun
Published: November 2015

The title reactions between substituted pyrimidin‐2‐yl sulfonates [e.g. (I)] and arylboronic acids, terminal alkynes, or anilines give the cross‐coupling products in good yields with wide substrate scope.
ChemInform Abstract: Efficient Multi‐Component Synthesis of 1,4‐Benzodiazepine‐3,5‐diones: A Petasis‐Based Approach.
Authors: Noushini Saeedeh , Mahdavi Mohammad , Firoozpour Loghman , Moghimi Setareh , Shafiee Abbas , Foroumadi Alireza
Published: November 2015

The one‐pot reaction between anthranilic acid amides (I), glyoxalic acid (II) and arylboronic acids (III) gives the title compounds in good yields.
ChemInform Abstract: A Simple and Green Procedure for the One‐Pot Synthesis of α‐Aminophosphonates with Quaternary Ammonium Salts as Efficient and Recyclable Reaction Media.
Authors: Yu Ya‐Qin , Xu Da‐Zhen
Published: November 2015

α‐Aminophosphonates are obtained from aldehydes or ketones with amines and diethyl or triethyl phosphite in excellent yields at room temperature within short time.
ChemInform Abstract: (+)‐ and (‐)‐Spiroreticulatine, a Pair of Unusual Spiro Bisheterocyclic Quinoline‐imidazole Alkaloids from the South China Sea Sponge Fascaplysinopsis reticulata.
Authors: Wang Qi , Tang Xuli , Luo Xiangchao , de Voogd Nicole J. , Li Pinglin , Li Guoqiang
Published: November 2015

The title compounds [cf.
ChemInform Abstract: A General Method for N‐Glycosylation of Nucleobases Promoted by (p‐Tol)2SO/Tf2O with Thioglycoside as Donor.
Authors: Liu Guang‐jian , Zhang Xiao‐tai , Xing Guo‐wen
Published: November 2015

Based on a preactivation strategy using the (p‐Tol)2SO/Tf2O system, a series of nucleosides are synthesized by coupling various thioglycosides such as (I), (IV), and (VII) with pyrimidine and purine bases.
ChemInform Abstract: A Multifunctional Nanocomposite of Magnetic γ‐Fe2O3 and Mesoporous Fluorescent ZnO.
Authors: Maiti Debabrata , Mukhopadhyay Soumita , Chandra Mohanta Subas , Saha Arindam , Sujatha Devi Parukuttyamma
Published: November 2015

The title nanocomposite is prepared by dispersing γ‐Fe2O3 and mesoporous ZnO in EtOH under sonication (250 W, 10 min) before mixing and refluxing (80 °C, 4 h).
ChemInform Abstract: Highly Efficient Red Phosphor Cs2GeF6:Mn4+for Warm White Light‐Eemitting Diodes.
Authors: Wang Zhengliang , Zhou Yayun , Liu Yong , Zhou Qiang , Luo Lijun , Tan Huiying , Zhang Qiuhan , Chen Guo , Peng Jinhui
Published: November 2015

Cs2GeF6:Mn4+ is prepared by cation exchange through addition of K2MnF6 and CsF to a GeO2 solution in HF (40 wt.%).
ChemInform Abstract: Recent Advances in the Synthesis and Electrocatalytic Applications of Platinum‐Based Bimetallic Alloy Nanostructures
Authors: Lai Jianping , Luque Rafael , Xu Guobao
Published: November 2015

Review: 160 refs.
ChemInform Abstract: Core—Shell Nanoparticles: Synthesis and Applications in Catalysis and Electrocatalysis
Authors: Gawande Manoj B. , Goswami Anandarup , Asefa Tewodros , Guo Huizhang , Biradar Ankush V. , Peng Dong‐Liang , Zboril Radek , Varma Rajender S.
Published: November 2015

Review: 476 refs.
ChemInform Abstract: Doping of TiO2 for Sensitized Solar Cells
Authors: Roose Bart , Pathak Sandeep , Steiner Ullrich
Published: November 2015

Review: 284 refs.
ChemInform Abstract: Metal‐Radical Coordination Complexes of Thiazyl and Selenazyl Ligands
Authors: Preuss Kathryn E.
Published: November 2015

Review: 116 refs.
ChemInform Abstract: Dynamic Behavior in Solution of Seven‐coordinated Transition Metal Complexes
Authors: Villafane Fernando
Published: November 2015

Review: 101 refs.
ChemInform Abstract: Multi‐component Coordination‐driven Self‐assembly Toward Heterometallic Macrocycles and Cages
Authors: Li Hao , Yao Zi‐Jian , Liu Dong , Jin Guo‐Xin
Published: November 2015

Review: 98 refs.
ChemInform Abstract: Schiff Base and Non‐Schiff Base Macrocyclic Ligands and Complexes Incorporating the Pyridine Moiety ‐ The First 50 Years
Authors: Rezaeivala Majid , Keypour Hassan
Published: November 2015

Review: 307 refs.
ChemInform Abstract: Metal Complexes with Pyridyl Azolates: Design, Preparation and Applications
Authors: Chi Yun , Tong Bihai , Chou Pi‐Tai
Published: November 2015

Review: 177 refs.
ChemInform Abstract: Recent Developments in the Thiamacrocyclic Chemistry of the Latter D‐Block Elements
Authors: Kim Seulgi , Lindoy Leonard F. , Lee Shim Sung
Published: November 2015

Review: 143 refs.
ChemInform Abstract: Neutral Discrete Metal‐Organic Cyclic Architectures: Opportunities for Structural Features and Properties in Confined Spaces
Authors: Thanasekaran Pounraj , Lee Cheng‐Hua , Lu Kuang‐Lieh
Published: November 2015

Review: 338 refs.
ChemInform Abstract: Discrete Metal‐Carboxylate Self‐Assembled Cages: Design, Synthesis and Applications
Authors: Ahmad Nazir , Chughtai Adeel H. , Younus Hussein A. , Verpoort Francis
Published: November 2015

Review: 134 refs.
ChemInform Abstract: Thiacalixarene‐Based Nanoscale Polyhedral Coordination Cages
Authors: Bi Yanfeng , Du Shangchao , Liao Wuping
Published: November 2015

Review: 39 refs.
ChemInform Abstract: The Bridging Azido Ligand as a Central “Player” in High‐Nuclearity 3d‐Metal Cluster Chemistry
Authors: Escuer Albert , Esteban Jordi , Perlepes Spyros P. , Stamatatos Theocharis C.
Published: November 2015

Review: 261 refs.
ChemInform Abstract: Sol‐Gel Organic‐Inorganic Hybrid Materials Containing Lanthanide Complexes with Polydentate Acyclic and Cyclic Ligands: Synthesis and Spectral‐Luminescent Properties
Authors: Smola S. S. , Snurnikova O. V. , Fadeyev E. N. , Rusakova N. V.
Published: November 2015

Review: 54 refs.
ChemInform Abstract: Postfunctionalization of the BODIPY Core: Synthesis and Spectroscopy
Authors: Boens Noel , Verbelen Bram , Dehaen Wim
Published: November 2015

Review: [104 refs.
ChemInform Abstract: Graphitic Carbon Nitride Polymers Toward Sustainable Photoredox Catalysis
Authors: Zheng Yun , Lin Lihua , Wang Bo , Wang Xinchen
Published: November 2015

Review: [91 refs.
ChemInform Abstract: Recent Advances in the Ruthenium‐Catalyzed Hydroarylation of Alkynes with Aromatics: Synthesis of Trisubstituted Alkenes
Authors: Manikandan Rajendran , Jeganmohan Masilamani
Published: November 2015

Review: [21 refs.
ChemInform Abstract: Triazole‐containing Carbohydrate Mimetics: Synthesis and Biological Applications
Authors: Xavier Nuno M. , Lucas Susana D.
Published: November 2015

Review: 112 refs.
ChemInform Abstract: Understanding the Enhanced Catalytic Performance of Ultrafine Transition Metal Nanoparticles‐Graphene Composites
Authors: Liu Xin , Meng Changgong , Han Yu
Published: November 2015

Review: 75 refs.
ChemInform Abstract: Core‐Structure‐Inspired Asymmetric Addition Reactions: Enantioselective Synthesis of Dihydrobenzoxazinone‐ and Dihydroquinazolinone‐Based anti‐HIV Agents
Authors: Li Shen , Ma Jun‐An
Published: November 2015

Review: [overview of the asymmetric synthesis of dihydrobenzoxazinone‐ and dihydroquinazolinone‐based anti‐HIV agents.
ChemInform Abstract: Glycosyltransferases: Mechanisms and Applications in Natural Product Development
Authors: Liang Dong‐Mei , Liu Jia‐Heng , Wu Hao , Wang Bin‐Bin , Zhu Hong‐Ji , Qiao Jian‐Jun
Published: November 2015

Review: 293 refs.
ChemInform Abstract: A Review of Electrolyte Materials and Compositions for Electrochemical Supercapacitors
Authors: Zhong Cheng , Deng Yida , Hu Wenbin , Qiao Jinli , Zhang Lei , Zhang Jiujun
Published: November 2015

Review: 507 refs.
ChemInform Abstract: π‐Electron Rich Small Molecule Sensors for the Recognition of Nitroaromatics
Authors: Shanmugaraju Sankarasekaran , Mukherjee Partha Sarathi
Published: November 2015

Review: [75 refs.
ChemInform Abstract: Current Pretreatment Technologies for the Development of Cellulosic Ethanol and Biorefineries
Authors: Silveira Marcos Henrique Luciano , Morais Ana Rita C. , da Costa Lopes Andre M. , Olekszyszen Drielly Nayara , Bogel‐Lukasik Rafal , Andreaus Juergen , Pereira Ramos Luiz
Published: November 2015

Review: [273 refs.
ChemInform Abstract: Designs of Functional π‐Electron Materials Based on the Characteristic Features of Boron
Authors: Wakamiya Atsushi , Yamaguchi Shigehiro
Published: November 2015

Review: [67 refs.
ChemInform Abstract: CFD Simulation of Dense Particulate Reaction System: Approaches, Recent Advances and Applications
Authors: Zhong Wenqi , Yu Aibing , Zhou Guanwen , Xie Jun , Zhang Hao
Published: November 2015

Review: CFD: computational fluid dynamics; 175 refs.
ChemInform Abstract: Fluorescence Based Explosive Detection: From Mechanisms to Sensory Materials
Authors: Sun Xiangcheng , Wang Ying , Lei Yu
Published: November 2015

Review: 286 refs.
ChemInform Abstract: X‐Ray Crystallography in Open‐Framework Materials
Authors: Bloch Witold M. , Champness Neil R. , Doonan Christian J.
Published: November 2015

Review: [32 refs.
ChemInform Abstract: Collision‐Induced Dissociation Mass Spectrometry: A Powerful Tool for Natural Product Structure Elucidation
Authors: Johnson Andrew R. , Carlson Erin E.
Published: November 2015

Review: 96 refs.
Double Asymmetric Induction During the Addition of (RP)‐Menthyl Phenyl Phosphine Oxide to Chiral Aldimines
Authors: Zhou Zhong‐Yang , Zhang He , Yao Lan , Wen Jing‐Hong , Nie Shao‐Zhen , Zhao Chang‐Qiu
Published: November 2015

P,C‐Stereogenic α‐amino phosphine oxides were prepared from the addition of (RP)‐menthyl phenyl phosphine oxide to chiral aldimines under neat condition at 80 °C in up to 91:9 drC and 99% yields. The diastereoselectivity was mainly induced by chiral phosphorus that showed matched or mismatched induction with (S)‐ or (R)‐aldimines, respectively. Chirality 28:132–135, 2016. © 2015 Wiley Periodicals, Inc.
Comprehensive Assessment of Heavy Metal Contamination in Surface Sediments from the Inflow Rivers of Taihu Basin
Authors: Cai Ying , Zhang Wenguang , Zhou Meichun , Jiang Hao , Xu Delin , An Shuqing , Leng Xin
Published: November 2015

The spatial variation, potential sources, and ecological risk of heavy metals (Cd, Co, Cr, Cu, Mn, Hg, Ni, Pb, and Zn) in surface sediments from the typical inflow rivers in Taihu Basin were investigated in June 2010. The results showed that the heavy metal concentrations varied greatly and spatially, and higher metal contamination mainly occurred in the northern and northwestern regions in Taihu Basin. Multivariate statistical analysis demonstrated that Mn might originate from natural sources, whereas Cd, Co, Cr, Cu, Hg, Ni, Pb, and Zn were primarily delivered from anthropogenic activities. The geoaccumulation index and enrichment factor values indicated that Cd, Cu, Cr, and Zn were moderately severe enriched, Ni and Pb were moderate enriched, while Co and Hg were at a minor enrichment level, which indicated that their contamination was not a major concern in the inflow rivers of the basin. Compared with the “Consensus‐Based Sediment Quality Guidelines,” Cr, Cu, Ni, and Zn were most likely to result in ecological toxicity for aquatic organisms. Although Cd was at moderately severe enrichment level, the probable effect concentration quotients of Cd < 1 implied it had no or low adverse effects on organisms. The results also suggest that Cr, Cu, Ni and Zn contamination in the north and northwest of the basin should be addressed as the first priority.
Design, Synthesis and Evaluation of Triazole‐Pyrimidine Analogues as SecA Inhibitors
Authors: Cui Jianmei , Jin Jinshan , Chaudhary Arpana Sagwal , Hsieh Ying‐hsin , Zhang Hao , Dai Chaofeng , Damera Krishna , Chen Weixuan , Tai Phang C. , Wang Binghe
Published: November 2015

SecA, a key component of the bacterial Sec‐dependent secretion pathway, is an attractive target for the development of new antimicrobial agents. Through a combination of virtual screening and experimental exploration of the surrounding chemical space, we identified a hit bistriazole SecA inhibitor, SCA‐21, and studied a series of analogues by systematic dissections of the core scaffold. Evaluation of these analogues allowed us to establish an initial structure–activity relationship in SecA inhibition. The best compounds in this group are potent inhibitors of SecA‐dependent protein‐conducting channel activity and protein translocation activity at low‐ to sub‐micromolar concentrations. They also have minimal inhibitory concentration (MIC) values against various strains of bacteria that correlate well with the SecA and protein translocation inhibition data. These compounds are effective against methicillin‐resistant Staphylococcus aureus strains with various levels of efflux pump activity, indicating the capacity of SecA inhibitors to null the effect of multidrug resistance. Results from studies of drug‐affinity‐responsive target stability and protein pull‐down assays are consistent with SecA as a target for these compounds.
Inspired by Nature: The 3‐Halo‐4,5‐dihydroisoxazole Moiety as a Novel Molecular Warhead for the Design of Covalent Inhibitors
Authors: Pinto Andrea , Tamborini Lucia , Cullia Gregorio , Conti Paola , De Micheli Carlo
Published: November 2015

Over the past few decades, there has been an increasing interest in the development of covalent enzyme inhibitors. As it was recently re‐emphasized, the selective, covalent binding of a drug to the desired target can increase efficiency and lower the inhibitor concentration required to achieve a therapeutic effect. In this context, the naturally occurring antibiotic acivicin, and in particular its 3‐chloro‐4,5‐dihydroisoxazole scaffold, has provided a wealth of inspiration to medicinal chemists and chemical biologists alike. In this Concept, to underline the great potentiality that the 3‐halo‐4,5‐dihydroisoxazole warhead has in drug discovery, we present a number of examples, grouped by their potential biological activity and targets, in which this scaffold has been fruitfully used to develop novel biologically active compounds. Through these examples, we show that the 3‐halo‐4,5‐dihydroisoxazole moiety represents an outstanding warhead with high potential for the design of novel covalent enzyme inhibitors.
Rapid Large‐Scale Synthesis of Vanadate Nanoscrolls with Controllable Lengths
Authors: Rostamzadeh Taha , Adireddy Shiva , Zhang Xiaodong , Koplitz Brent , Chrisey Douglas B. , Wiley John B.
Published: November 2015

A simple one‐step solvothermal synthetic approach has been applied to the rapid fabrication of VOx nanoscrolls (NScs) from vanadium pentoxide and either dodecylamine or octadecylamine as the structure‐directing agent (SDA). By reaction of the appropriate ratio of SDA to vanadium oxide and solvent at 250 °C, approximately 20 g of NScs per synthesis could be formed within 2 h. Syntheses could be further adjusted so that the average lengths of the NScs could be varied from approximately 383 to 816 nm to 3.3 μm. The effect of synthesis parameters such as temperature, solvothermal reaction duration, and vanadium oxidation state on the formation of NScs was also investigated; detailed studies indicate that the variation between V4+ and V5+ appears to play a critical role in the formation of vanadate NScs.
Accelerating Asian option pricing on many‐core architectures
Authors: Li Shuo , Lin James
Published: November 2015

In this paper, we start by looking at the algorithms and the numerical methods of pricing one exotic option, the strong path dependent Asian option using the Black–Scholes pricing model. We cover both geometric average and arithmetic average schemes that lead us to two different numerical solutions. Next, we discuss how to implement these algorithms on the leading many‐core architectures with contrasting programming models and still achieve the comparable performance results. As an example, we will show that a 2‐year contract with 252 times steps and 1,000,000 samples can be priced in approximately one fifth of a second on two leading many‐core architectures. The purpose of this paper is to understand what is required to accelerate the numerical‐intensive algorithms such as the Asian option pricing algorithm in quantitative and how to take advantage of the parallel programming features on many‐core architecture and express parallelism inherent in the similar algorithms in quantitative finance. Copyright © 2015 John Wiley & Sons, Ltd.
Assessment of in vitro metabolic stability, plasma protein binding, and pharmacokinetics of E‐ and Z‐guggulsterone in rat
Authors: Chhonker Yashpal S. , Chandasana Hardik , Mukkavilli Rao , Prasad Yarra Durga , Laxman Tulsankar Sachin , Vangala Subrahmanyam , Bhatta Rabi S.
Published: November 2015

Guggulsterone is a racemic mixture of two stereoisomers (E‐ and Z‐), obtained from the gum resin of Commiphora mukul and it is marketed as an antihyperlipidemic drug. The aim of our study was to assess the in vitro and in vivo absorption, distribution, metabolism, and excretion (ADME) properties namely solubility, in vitro metabolism, plasma protein binding and oral pharmacokinetic studies of E‐ and Z‐guggulsterone. In vitro metabolism experiments were performed by using rat liver and intestinal microsomes. In vitro intrinsic clearance (CLint) was found to be 33.34 ± 0.51 and 39.23 ± 8.12 μL/min/mg protein in rat liver microsomes for E‐ and Z‐isomers, respectively. Plasma protein binding was determined by equilibrium dialysis method and in vivo pharmacokinetic studies were performed in male Sprague Dawley (SD) rats. Both isomers were highly bound to rat plasma proteins (>95% bound). Plasma concentration of E‐ and Z‐isomers decreased rapidly following oral administration and were eliminated from systemic circulation with a terminal half‐life of 0.63 ± 0.25 and 0.74 ± 0.35 h, respectively. The clearance (CL) for E‐isomer was 2.79 ± 0.73 compared to 3.01 ± 0.61 L/h/kg for Z‐isomer, indicating no significant difference (student t test; p <0.05) in their elimination.The pharmacokinetics of both isomers was characterized by extensive hepatic metabolism as seen with rat liver microsomes with high clearance and low systemic availability in rats. In brief, first‐pass metabolism seems to be responsible factor for low bioavailability of guggulsterone. Copyright © 2015 John Wiley & Sons, Ltd.