bluuebunny/crossref_metadata_2025 huggingface dataset:
Tax law system in the context of digitalization: problems and prospects
Authors: Lyutova O. I.
Published: March 2024

The purpose of the article is to develop a criterion for structuring the branch of tax law relevant for the period of digitalization.

The methodology of the study includes an analysis of regulatory acts of tax legislation regulating the legal regulation of digital transformation of taxation.

The main results and the scope of their application. Due to the lack of a single criterion for the formation of the structure of tax law (in different years, the tax system or the system of tax legislation was considered as such), obstacles are created in the unambiguity of understanding the system and types of tax law institutions. This leads to a number of practical problems related to the “alignment” of new tax law norms that appeared in the digital era into the “classical” tax legal relationship.

Conclusions. The criterion on the basis of which the modern legislator, as well as representatives of the tax and legal doctrine, divides tax law into institutions is a controversial issue of the relevant branch of science. Such uncertainty does not give an unambiguous understanding of the legal nature of new tax law institutions, for example, the institute of a single tax payment. At the present stage, it would be logical to use the category of “tax obligation” as a kind of link in the system of tax law, which is predetermined by its fundamental role in tax and legal regulation.
Production control problem for multi-product multi-resource make-to-stock systems
Authors: Özkan Sinem , Bulut Önder , Dinçer Mehmet Cemali
Published: March 2024

Most of today's production systems are working with parallel production resources to increase throughput rate due to the increase in high variability in demand and product mix. Effective control and performance evaluation of such systems is of paramount importance to minimize production and inventory-related costs. We examine a production-inventory system featuring parallel production resources capable of producing various products. In many industries such as automotive, white goods, electronics, and paint, multiple/parallel production resources are widely used to produce the ideal amount and satisfy incoming demands for distinct products. In this study, shortage cost is not restricted to only one type and both lost sales and backordering cases are analyzed. In order to analyze the optimal production policies' behavior, we initially formulate dynamic programming models for both lost sales and backordering systems, treating them as Markov Decision Processes. Subsequently, we solve these models using the value iteration algorithm. Given the challenges posed by the curse of dimensionality in the value iteration algorithm, we suggest alternative heuristic production policies. These policies extend the existing ones described for multi-item single-resource make-to-stock (MTS) systems to accommodate multiple resources. We construct simulation models to assess the efficacy of the heuristic policies, conducting comparisons of their performance against both the optimal policy and among one another. To the best of our knowledge, there has been no exploration of scenarios involving multiple production resources concurrently manufacturing distinct products in a MTS environment. Hence, this study serves as an extension to the examination of multi-item, multi-production resource MTS systems.
Truck-drone joint path planning for post-disaster emergency material deployment considering fairness
Authors: Hong Wei , Liu Shuaichen , Xu Shuling , Pu Xujin
Published: March 2024

As the expert gear of the emergency rescue system, drones are frequently utilized to distribute supplies following a calamity. The cost and effectiveness of rescue efforts as well as equitable distribution should be taken into account when allocating emergency supplies to disaster-affected areas. This work explores the emergency material allocation problem for truck-drone joint transportation with dynamic energy restrictions based on taking the fairness of emergency material allocation into consideration. In order to guarantee the equitable distribution of materials, the psychological stress experienced by the victims at each catastrophe site is measured using the relative deprivation cost. An adaptive large-scale neighborhood search method serves as the foundation for the creation of a two-stage heuristic algorithm, which reduces the overall cost of the system. The integer programming model MIP is built for this purpose. The research findings can serve as a useful guide for developing a just and effective emergency drone rescue system, and the testing results demonstrate the viability and effectiveness of the two-stage heuristic algorithm.
A GRASP algorithm for the bus crew scheduling problem
Authors: Pardo-Peña David , Álvarez-Martínez David , Escobar John Willmer
Published: March 2024

This paper proposes a GRASP approach for solving the Bus Crew Scheduling Problem (BCSP) to find high-quality solutions within short computing times. The BCSP described the process related to the assignment of drivers and conductors to a bus company's regular daily operation of a mass transit system, seeking to minimize the cost of operation and, at the same time, the improvement of the working environment by considering the satisfaction of the drivers with the assigned shifts. The BCSP has drivers in charge of covering the demand for shifts, with an assignment that contains several constraints, such as minimum and maximum work blocks, minimum rest days, and shift sequences that must not be assigned. The former GRASP algorithm is proposed with a constructive procedure, a solution repair procedure, and two local search operators. Classical instances from the literature have been adapted for the shift assignment problem by adding a satisfaction variable. Besides, the proposed approach has been tested for a real company operating articulated and feeder vehicles. The results show that the satisfaction function adds value to the assignments, substantially improving the work environment and generating favorable results in terms of time and quality of the solution.
An extended PSO algorithm for cold-chain vehicle routing problem with independent loading and minimum fuel volume
Authors: Xu Song , Zong Jianfan , Liu Lu , Yang Wenting , Xu Lu
Published: March 2024

With the increasing complexity of the distribution environment, customers usually propose higher requirements, such as independent loading of local and foreign cold-chain items in the event of an emergency. Moreover, minimum fuel volume plays an important role in the process of transportation with different speeds and different kinds of vehicles. In this paper, we present a new mathematical model to characterize cold-chain vehicle routing optimization with independent loading of local and foreign items and minimum fuel volume. To address the above mathematical model, an extended particle swarm optimization (PSO) algorithm is proposed by combining original PSO with 2-opt optimization to improve diversity and reduce convergence speed. Six sets of experiments are set to verify the practical performance and stability of the extended PSO algorithm based on three standard datasets of C201, R201, and RC201 from Solomon.
A case study of whale optimization algorithm for scheduling in C2M model
Authors: Shan Hongying , Shan Xinze , Zhang Libin , Qin Mengyao , Peng Peiyang , Meng Zunyan
Published: March 2024

With the continuous upgrading of industrial technology and information technology, consumers can deeply participate in the whole life cycle of products and realize customized production. These unprecedented changes have brought consumers and manufacturers closer together, resulting in the intelligent business model of "Internet + Customized Production" and "Customer to Manufacturer (C2M)". C2M has been adopted by more and more companies. However, the transition from traditional business models to C2M is a problem that every company must face and solve. Personalized orders of many varieties and small lots put enormous pressure on the production of mainly labor-intensive electronic assembly companies. The theoretical findings of Industry 4.0 and Lean Manufacturing show that people play a central role in assembly operations. As an important element of the production system, worker scheduling has a direct impact on delivery time and cost. Worker scheduling requires not only matching people to jobs, but also considering flexible employment. According to the "Learning Curve" theory, workers with learning potential can continuously enrich their skills and work efficiency will show dynamic changes. Therefore, under the condition of shortest order delivery time and lowest cost, worker scheduling considering the learning effect becomes a challenge for enterprise decision makers. Firstly, the production method of manufacturing industry in C2M environment is studied. Then, based on single-skill task and multi-skill task, respectively, a learning curve-based model of dynamic change in worker skill level is constructed. And this model is used as the input of the assembly line worker scheduling model. Secondly, an Elite Non-dominant Sorting Whale Optimization Algorithm (ENS-WOA) is designed for this multi-objective optimization problem. The correctness and feasibility of the proposed algorithm are verified by selecting classical arithmetic cases for experimental comparison with other algorithms. Finally, the established worker efficiency change model, worker scheduling model and the proposed algorithm are applied to optimize the assembly line of water pump products of Company B, which is being transformed to C2M, and solved by MATLAB software. The results show that the model proposed in this paper is effective, stable and practical compared with the worker costs and delivery period required to complete the order in the original assembly line. Worker costs were reduced by 29.02% and orders were completed approximately 10 days earlier.
A Comprehensive Review on Floating Drug Delivery System
Authors: D. Lahamge Pradnya , M. More Yashpal , P. Ahire Pallavi , R. Kothawade Vinay
Published: March 2024

The category of gastroretentive drug delivery systems (GRDDS) includes floating drug delivery systems (FDDS). These dose formulations are intended to extend the duration of the stomach's residence period by a sustained release technique. Drugs which are harder to dissolve in high pH environments have improved bioavailability and solubility when incorporated into GRDDS. Reduced intestinal absorption of solid dose forms can be accomplished by the flotation mechanism. The novel fusion of bilayer and floating mechanism is demonstrated by the bilayer floating drug delivery device. It demonstrates the effective creation of a controlled release formulation. Bilayer floating tablets offer a sustained release layer formulation in addition to an immediate release. A attempt was made to explain the mechanism of FDDS, or floating bilayer, in the review. In order to accomplish regulated administration of various medications with predetermined release profiles, bi-layer tablets were developed. The pharmaceutical industry has been more interested in creating bilayer tablets over the past ten years as a way to improve patient compliance and convenience by combining two or more API in a single dose form.
Recent Advances on Bilayer Tablet
Authors: R. Kothawade Vinay , M. More Yashpal , D. Lahamge Pradnya , P. Ahire Pallavi
Published: March 2024

When the high cardiac output exerts pressure on the arterial wall as blood flow increases, hypertension, or high blood pressure, occurs. Bi-layer tablets consists with one layer of the drug prepared for immediate release or a second layer intended for sustained release, these can be used as an sustained release method or as a second dose. A bi-layered tablet is used to break away two chemicals that are incompatible, release both drugs continually in combination, or create a sustained release tablet with an initial dose that is released immediately and a maintenance dose that is granted as with time. Bilayer tablets can be used for sustained release tablets, where the first layer is immediate release as the initial dose and the second layer is delayed release. It can also be used for the sequential release of two drugs combination or at separate two incompatible items.
Navigating the Global Landscape: A Comprehensive Review of Bower and Sulez's Strategic Insights in the Pharmaceutical Industry
Authors: R Aishwarya , Abdul Ahad Hindustan , S Varsha , V Ranjitha
Published: March 2024

Bower and Sulez's work on global pharmaceutical strategy stands as a comprehensive analysis of the intricate landscape within this highly regulated and fiercely competitive industry. This article delve into critical themes, including regulatory compliance, market access strategies, and the role of innovation, acknowledging the industry's complexity marked by stringent regulations and intense competition. Emphasizing a holistic approach, the study explores nuanced strategies for navigating diverse regulatory frameworks globally, effective market entry, pricing considerations, and adapting to regional healthcare needs. Furthermore, the article highlight the significance of research and development, providing insights into fostering innovation, safeguarding intellectual property, and strategic collaborations. The work offers a balanced framework, addressing challenges and opportunities, making it a valuable resource for industry practitioners and future research in the dynamic global pharmaceutical sector.
Review on Orodispersible Tablet
Authors: P. Ahire Pallavi , M. More Yashpal , R. Kothawade Vinay , D. Lahamge Pradnya
Published: March 2024

Systems for orodispersible drug delivery are widely used to increase patient compliance and bioavailability. Because of their enhanced solubility, stability profiles, and higher patient compliance compared to traditional tablets and capsules, orodispersible tablets (ODTs) have drawn a lot of attention in the last thirty years. The review of possible developments in ODT technology for drug delivery applications is the article's main goal. ODTs are prepared using a variety of methods, such as mass extrusion, tablet moulding, sublimation, freeze drying, and direct compression. ODTs may be the better option, particularly for GI-sensitive medications and for patients who fall into the paediatric, geriatric, bedridden, postoperative, or other categories and may have trouble swallowing traditional tablets and capsules. When placed on the tongue, ODTs-solid dosage forms containing medication-disintegrate quickly, often within a few seconds. ODTs have higher acceptability because of their increased bioavailability and stability, as well as patient compliance. This article examines current developments in ODT development, including new technologies, drug candidate suitability, and ODT characterization.
Nano Sponge: An Emerging Nano-Technology Based Drug Delivery System
Authors: Shah Rikhav , Chavda Dipika
Published: March 2024

In current scenario medical experts have long struggled with how to deliver medication to targeted location into the body while also controlling the drug release rate to avoid overdosing. This issue may be resolve through the creation of novel, intricate formulation known as nano sponges. Nano sponges are small sponge, all around size virus, that may hold a range of medication. These microscopic sponges can move through the system until they reach the intended target region, where they adhere to surface and start to release the drug in steady and controlled manner. Nano sponges are a network or 3D polyester scaffold that are spontaneously decompose. These polyesters are combined with cross-linkers agent in a solution to create a nano sponge. When loaded nano sponge’s framework breakdown the drug particle is released. They are mostly in solid form and it can be formulated as oral, parenteral, topical, or inhalation dosage form, several studies havebeen conducted on protein, peptide, genes, anti-cancer biomolecules via nano-particle technology which hep to reduce undesirable effect and enhance efficacy.
A Review on Effective Treatment of Chronic Skin Allergy using Chlorpheniramine
Authors: Rathore Nikhil , Taiger Abhishek , Prasad Suruchi
Published: March 2024

Allergies, is a bunch of medical circumstances caused by the hypersensitivity of the immune system to typically harmless substances in the environment. Allergy can be a type of hay fever, food allergies, atopic dermatitis, allergic asthma, and anaphylaxis. Symptoms of allergy include red eyes, an itchy rash, sneezing, coughing, a runny nose, shortness of breath, or swelling. Antihistaminics are very useful candidates to treat allergy. The dose of antihistaminics can be reduced by local administration of anti-histaminics at the site of allergy. Skin allergy is basically related to dermal site of the skin it replicates to other organ near or in contact with skin. Administration of chlorpheniramine directly to the shin as topical drug delivery system will help to reduce the skin allergies.
Nanorobotics: Pioneering Drug Delivery and Development in Pharmaceuticals
Authors: Kumar Sarella Prakash Nathaniel , Kumar Vipparthi Anil , Valluri Surekha , Vegi Srujala , Kumari Vendi Veera
Published: March 2024

Nanorobotics, a rapidly evolving field at the intersection of nanotechnology and robotics, holds immense promise in revolutionizing pharmaceutical drug delivery and development. This comprehensive review article explores the various facets of nanorobotics and its pivotal role in the advancement of medicine. The article begins with an introduction to nanorobotics, providing a definition and historical background to contextualize its significance. Subsequently, it delves into nanorobotics' role in drug delivery, highlighting the challenges faced in conventional methods and the advantages of employing nanorobot-based systems. The review further explores nanorobotics in drug development, emphasizing its contribution to accelerating drug discovery and enabling personalized medicine. It discusses the different types of nanorobots utilized in pharmaceutical applications, including molecular, cellular, and hybrid systems. Additionally, the article covers the fabrication and propulsion techniques of nanorobots, along with navigation and control strategies. Furthermore, it delves into the interaction of nanorobots with biological systems and their potential applications in site-specific drug delivery and disease treatment. Ethical and regulatory considerations pertinent to nanorobotics in pharmaceuticals are also addressed. Finally, the review offers insights into future perspectives and challenges in the field, envisioning advanced drug delivery systems, targeted therapies, nanorobot swarms, and biohybrids. By comprehensively examining the subject, this review article presents a holistic understanding of nanorobotics potential in reshaping pharmaceutical practices for precision medicine and improved patient outcomes.
A Concise Overview on Orodispersible Film along with their Formulation and Characterization Technique’s
Authors: Singh Navdeep , Sweta Sweta , Jindal Shammy
Published: March 2024

Orally fast-dissolving medicine delivery techniques are increasingly common at present. Due to the desire for these delivery systems, oro-dispersible film (ODF) was recently introduced for the delivery of medicines via the oral route. Most of drugs are delivering through oral route in the form of tablets, capsules and liquids, because they are simple to make and have a greater level of patient compliance. But these conventional dosage forms have many problems including big size of dosage form, and fear of chocking. Oral rapid disintegrating/oro-dispersible drug delivery systems were created to tackle such issues. Fast dissolving films were invented for the patients who have swallowing issues with conventional/traditional oral solid dosage forms. They also have a quick onset of effect, taking only a few seconds, because the drug is absorbed directly from the injection site to the systemic circulation, avoiding first-pass metabolism. In the preparation of films, polymers, surfactants, flavoring agents, coloring agents, sweetening agents, saliva stimulating agents, drug, and plasticizer are used. The drug incorporated in ODF should have pleasing taste, low molecular weight, high stability, and high aqueous solubility. Solvent and semisolid casting, hot melt extrusion, and rolling techniques are routinely used to prepare ODFs. Thickness, loss on drying, tensile strength, and elongation percentage are commonly assessed for evaluating ODFs, as well as their resistance to tearing, weight variation, folding endurance, pH, swelling property, transparency, disintegration, dissolution rate, and stability. The purpose of this review article is to provide a quick overview of ODF delivery systems.
Auditors' Perception on Ethical Responsibility in Auditing: A Qualitative Study
Authors: Wijaya Ari , Suryani Bella , Pratama Cindy , Permadi Dito , Putri Eka
Published: March 2024

This qualitative study explores auditors' perceptions of ethical responsibility in auditing, aiming to elucidate the multifaceted dynamics shaping their attitudes and behaviors. The research delves into various dimensions of ethical behavior, organizational factors, professional standards, and regulatory frameworks influencing auditors' conduct. Through thematic analysis of existing literature, key concepts related to ethical responsibility in auditing are defined, and specific aspects pertinent to the research context are elucidated. The study highlights the critical role of ethical behavior in maintaining public trust and confidence in financial reporting, emphasizing principles of integrity, objectivity, independence, and professional competence. Organizational culture, professional norms, and regulatory oversight mechanisms are identified as influential factors shaping auditors' ethical decisions and actions. Moreover, the research underscores the importance of professional skepticism and independence as essential components of auditors' ethical responsibility, emphasizing their role in enhancing audit quality and deterring financial misconduct. The findings contribute to theoretical discourse on auditing ethics, enriching our understanding of the ethical imperatives governing auditors' conduct. Furthermore, practical implications for auditing firms, regulatory bodies, and professional associations are discussed, with recommendations for promoting ethical conduct and integrity within the profession.
The Impact of Information Technology on the Audit Process: Auditors' Perspectives
Authors: Santoso Bima
Published: March 2024

This qualitative study explores auditors' perceptions of ethical responsibility in the auditing profession, aiming to elucidate the complexities of ethical decision-making. Through semi-structured interviews, seasoned auditors provided insights into their experiences, attitudes, and challenges related to ethical conduct. The research employed a phenomenological approach to understand the essence of auditors' lived experiences concerning ethical responsibility. Data collection involved semi-structured interviews with practicing auditors, allowing for in-depth exploration of their perspectives. A purposive sampling strategy was adopted to select participants with relevant knowledge and experience in IT-enabled auditing practices. Thematic analysis was utilized to analyze interview transcripts and identify key themes and patterns. The findings revealed that auditors perceive ethical responsibility as fundamental to their professional identity, emphasizing the importance of upholding ethical standards, maintaining independence, and exercising professional judgment. Challenges in ethical decision-making included pressure from clients, financial incentives, time constraints, and conflicting demands from stakeholders. Organizational culture emerged as a critical factor influencing auditors' ethical behavior, highlighting the importance of ethical leadership, firm policies, and peer behavior. The study underscores the need for comprehensive ethical training, organizational support, and regulatory oversight to promote ethical conduct among auditors and uphold the credibility of the auditing profession.
Audit Quality and Its Influence on Stakeholder Trust: A Qualitative Analysis
Authors: Surya Dika , Pratiwi Eka , Wijaya Galang , Permadi Hani , Suryani Ina
Published: March 2024

This qualitative study aims to explore the intricate relationship between audit quality and stakeholder trust in financial reporting. Through in-depth interviews with auditors, investors, regulators, and corporate executives, insights were gathered regarding perceptions, experiences, and expectations concerning audit quality and its influence on stakeholder trust. Thematic analysis revealed key dimensions of audit quality, including auditor independence, competence, objectivity, adherence to professional standards, and perceptions of audit effectiveness. Stakeholders emphasized the importance of transparent disclosure practices, accountability in corporate governance, credibility of auditors and financial statements, and regulatory oversight in fostering trust in financial reporting. The findings underscored the pivotal role of regulatory bodies, such as the PCAOB and SEC, in promoting audit quality, deterring fraudulent behavior, ensuring auditor accountability, and maintaining market confidence. Overall, the study contributes to a deeper understanding of the mechanisms shaping stakeholders' perceptions of audit quality and trust in financial reporting, with implications for market efficiency, investor protection, and corporate governance.
Auditing in the Digital Era: Challenges and Opportunities for Auditor
Authors: Rahman Fadhil , Putri Gina , Wulandari Dina , Pratama Dedi , Permadi Eka
Published: March 2024

This qualitative study explores the challenges and opportunities faced by auditors in the digital era, focusing on data privacy concerns, cybersecurity threats, skills shortages, and regulatory complexities. Grounded theory methodology was employed to analyze literature encompassing auditing in the digital environment. Data collected from various scholarly sources were systematically reviewed, synthesized, and analyzed using open and axial coding techniques. The findings reveal that auditors encounter significant challenges related to navigating stringent data privacy regulations such as the GDPR and CCPA, addressing evolving cybersecurity threats, mitigating skills shortages in critical areas like data analytics and cybersecurity, and complying with dynamic regulatory frameworks like ISAs, GAAS, and SOX. However, amidst these challenges, auditors also have opportunities to enhance audit quality through advanced technologies like data analytics and AI, expand their scope of assurance services, and improve client collaboration using digital communication tools. The study underscores the importance of proactive measures to address skills shortages, foster collaboration between auditors and stakeholders, and adapt audit methodologies to the digital landscape. Overall, the research provides insights into the complex interplay between auditors, digital technologies, and regulatory environments, offering implications for audit practice, education, and research.
Analysis of the Role of Internal Audit in Enhancing Company's Internal Control
Authors: Sari Dian Kartika
Published: March 2024

This study aims to explore the role of internal audit in enhancing a company's internal control system by examining internal audit practices, perceptions of internal control effectiveness, and the impact of internal audit recommendations. The research employs a qualitative approach, utilizing interviews and document analysis to gather data from participants representing various organizations. Results reveal significant variations in internal audit practices influenced by organizational size, industry dynamics, and regulatory frameworks. Despite these variations, internal audit functions universally serve as guardians of organizational integrity, providing independent assurance regarding internal control effectiveness. Participants expressed diverse perceptions of internal control effectiveness, citing resource constraints, inadequate training, and communication gaps as common challenges. However, internal audit was unanimously recognized as crucial in enhancing internal controls, offering independent assurance and promoting a culture of compliance and ethical behavior. Internal audit recommendations often led to tangible improvements in internal control systems, although challenges related to resource allocation and change management were reported. Theoretical implications highlight the multifaceted nature of internal audit functions and their critical role in organizational governance, while managerial implications emphasize the need for strategic resource allocation, prioritization, and change management initiatives. This research contributes to the understanding of internal audit practices and their impact on organizational effectiveness.
Analysis of the Role of Internal Audit in Enhancing Company's Internal Control
Authors: Anwar Fadhilah Rahma
Published: March 2024

The qualitative investigation into auditing strategies within multinational companies aims to explore and understand the effectiveness of various approaches in addressing fraud risks. Employing purposive sampling, key stakeholders including senior executives, auditors, and regulatory authorities were interviewed. Additionally, document analysis was conducted on relevant organizational documents. Thematic analysis was employed to derive patterns and insights from the data. Findings reveal that internal auditing plays a foundational role in assessing internal controls and identifying vulnerabilities, while external audits enhance transparency despite concerns about auditor independence. Forensic auditing emerges as crucial in uncovering fraudulent activities, and the integration of data analytics shows promise in enhancing fraud detection capabilities. Contextual factors such as geographic dispersion and cultural diversity present challenges, while stakeholder perceptions underscore the strategic importance of effective fraud risk management. Recommendations include prioritizing proactive measures, fostering collaboration, and strengthening corporate governance mechanisms to mitigate fraud risks effectively. This research contributes insights into enhancing fraud risk management practices within multinational corporations.
The Influence of Work Culture on the Effectiveness of Internal Audit: A Qualitative Study
Authors: Surya Fransiska , Pramudita Tan , Wijaya Dina , Permadi Dodi , Putri Eka
Published: March 2024

This qualitative study investigates the influence of organizational culture on the effectiveness of internal audit processes within organizations. Through a comprehensive literature review and supplementary data collection methods, including interviews with internal auditors and organizational leaders, the study explores the intricate relationship between work culture and internal audit outcomes. The research draws on theoretical frameworks such as agency theory and social identity theory to conceptualize the influence of organizational culture on audit practices and performance. The findings reveal that a strong organizational culture characterized by ethical norms, transparency, and accountability enhances internal audit effectiveness by fostering trust, compliance, and collaboration among employees. Conversely, a weak or dysfunctional culture may impede audit effectiveness by hindering communication, collaboration, and compliance. The study highlights the importance of cultivating a supportive culture that aligns with audit objectives to optimize audit outcomes and promote organizational success. These insights contribute to a deeper understanding of the mechanisms through which organizational culture influences internal audit effectiveness and offer practical implications for organizations seeking to enhance audit performance and organizational resilience.
Triple Negative Breast Cancer (TNBC): Signalling pathways-Role of plant-based inhibitors
Authors: Ravindra B. Malabadi  , Sadiya MR  , Kiran P. Kolkar  , Simuzar S. Mammadova  , Raju K. Chalannavar  , Himansu Baijnath  , Lavanya L  , Antonia Neidilê Ribeiro Munhoz
Published: March 2024

This review paper highlights and updates the role of plant based inhibitors in controlling the triple-negative breast cancer (TNBC) via blocking the TNBC signalling pathways. Breast cancer is the most common cancer in women. There are several identified types, among which the triple-negative breast cancer (TNBC) is the most fatal for patients. Conventionally, the triple-negative breast cancer (TNBC) is defined by the lack of estrogen receptor (ER), progesterone receptor (PR), and human epidermal receptor 2 (HER2) in breast cancer cells. It is well-known for its metastatic, aggressive characteristics and poor outcome in the clinic. Till today, the treatment of TNBC patients is still a challenging task due to the absence of appropriate targets for drugs. Despite the successes of emerging targeted therapies, relapse, recurrence, and therapy failure rates in TNBC significantly outpace other subtypes of breast cancer. Mounting evidence suggests an accumulation of therapy resistant, Cancer Stem Cell (CSC) populations within TNBCs contributes to poor clinical outcomes. These Cancer Stem Cells (CSC) are enriched in TNBC compared to non-TNBC breast cancers. Approximately 60% of drugs currently used for cancer treatment have been isolated from natural products. Natural plant based products are a well-known treasure house for the development of novel anticancer drugs. Many plant-derived natural compounds have anti-cancer properties, including berberine quercetin, formononetin, calycosin, polyphenols, bioflavonoids, carotene, vitamins, and andminerals. Many plant-derived natural compounds, including vinka alkaloids, vinblastine and vincristine, luteolin, α-mangostin, piperine, silibinin, apigenin, quercetin, fisetin, resveratrol, genistein, 10-gingerol, chalcones, curcumin, epigallocatechin gallate, cyanidin-3-O-glucoside, and glycyrrhizin, have shown anti-cancer properties, especially in the treatment of TNBCs. Therefore, more human clinical trial data is warranted for further evaluation of plant extracts for the treatment of TNBCs.
Adaptive changes in the political field of Ukraine in the conditions of war
Authors:   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Rafalskiy О. , Zelenko G. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Pereveziy V. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Karmazina M. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Sytnyk S. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Breharya S. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Lyashenko T. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Shaihorodskyi Yu. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Bevs T. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Kononenko N. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Kulyk V. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Yaremchuk V. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Nikolayets Yu. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Kochan N. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Kotygorenko V. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Maiboroda O. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Kondratenko O. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Kiyanitsa L. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine, Kyyak M. ,   Kuras Institute of Political and Ethnic Studies of the National Academy of Sciences of Ukraine
Published: March 2024

The monograph contains an analysis of the changes that have taken place in the political field of Ukraine under the influence of the war unleashed by Russia. The authors focused on the key aspects of political changes in Ukraine caused by the martial law conditions – functional changes in the country’s political system, new formats of relations between the government and society, innovations in the implementation of the Euro-Atlantic course of the Ukrainian state. The subject area of the analysis of political changes in the country is the functioning of political and governmental institutions, the nature of political governance in accordance with the intensification of social processes in the spiritual, cultural, ethno-political spheres, and the search for ways to integrate Ukraine into the world democratic space. For researchers, teachers, students, analysts, and anyone interested in the development of political processes in the country.
PERTOBATAN EKOLOGIS DALAM TERANG ENSIKLIK LAUDATO SI
Authors: Maru Titus Paulus Maru , Silan Kristofel , Lengkey Seravin
Published: March 2024

The focus of this scientific paper is ecological conversion. The author sees it from the perspective of Pope Francis Laudato Si's Encyclical. Today it cannot be hidden that injustice to the environment, flora and fauna, natural resources, and fellow human beings is a serious problem. The author can call this problem ecological injustice. Because of that, the author takes the theme of ecological repentance in the light of the Encyclical Laudato Si. The purpose of this scientific writing is that the writer discover the concept of ecological conversion and realizes the concept of ecological conversion in the light of Laudato Si's Encyclical. In the process of scientific writing, the author uses two sources. The first source, let's say as a primary source, is the Encyclical Laudato Si. The second source as a secondary source is an article that has been previously written by another author. The author searches for these sources by using Google. The trick is to search for Google Scholar. The author uses the method of reading and analyzing primary sources and secondary sources as a reference to further strengthen the author's argument. After about 1 month, the writer managed to find two points as the purpose of this writing. First, the concept of repentance according to Laudato Si, realizes that the earth belongs together as brothers and sisters. This requires confessing sin as a form of God's presence in the world. What is prioritized is the motivation born of spirituality to preserve nature. Second, realizing the concept of ecological repentance. we must have education and spirituality as capital to view other creations as brothers. This from the Encyclical Laudato Si is proof that the Catholic Church has a living love, so that love is manifested with a sense of concern for God's fellow creatures.
PEMAHAMAN UMAT PAROKI TRINITAS MAHAKUDUS PASLATEN TENTANG TINDAKAN LITURGIS DALAM EKARISTI
Authors: Lontoh Raymond , Mayokan Eduard , Raga Vinsensius
Published: March 2024

This study aims to know and understand the liturgical actions that occur in the parish of the Holy Trinity Paslaten. Then the researcher proceeds to the search for the level of liturgical understanding, especially the liturgical action of the people. In the end, we will know how liturgical teaching compares with the liturgical understanding and liturgical action of the people. The methods used are observation, interviews, and literature studies. Observation is made to observe liturgical actions that are carried out by people in liturgical celebrations. Interviews were conducted to determine the level of understanding and meaning of the people regarding the liturgical actions they carried out. A literature study was conducted to find out about the official teaching of the Church regarding liturgical action. Important results found are: the practice of liturgical action is often incompatible with teaching. The practice of the sign of the cross, standing, kneeling, and sitting is often not done properly and correctly. Such liturgical practices often also lose meaning and significance. However, there are still people who faithfully and passionately carry out these liturgical acts. From these results, it can be concluded that liturgical actions have not been fully carried out properly and correctly, nor have they often lost their meaning. The pastoral recommendations offered are good liturgical teaching and complete facilities to support liturgical action.
Ocorrência da Doença de Haff no Brasil de 2008-2022 na perspectiva do conceito de Saúde Única
Authors: Coelho Nathália , Santana Eucilene , Bruno Morgana , Sá Isabella , Gurgel Helen
Published: March 2024

Contexto: Desde 2008, casos da Doença de Haff foram detectados por meio de surtos pontuais investigados no norte e nordeste do país, mas sem identificação do agente e/ou fatores de risco para o adoecimento até o momento. O presente trabalho visou sistematizar a distribuição e o conhecimento da doença na população humana brasileira, disposto a contribuir com propostas de pesquisas ambientais e epidemiológicas no contexto da saúde única para a identificação dos fatores de risco até o adoecimento da população. Desenvolvimento: Realizou-se revisão com palavra-chave “Doença de Haff” em português, espanhol, inglês e francês em plataformas de pesquisas em saúde e ambiente, sem delimitação de período, mas com exclusão das literaturas que não abordavam casos da doença no Brasil no título e nas palavras-chave. As 37 informações de interesse foram coletadas dos artigos selecionados por meio de formulário online semiestruturado e analisado de forma qualitativa. Resultados: Dos 57 artigos elegíveis, seis abordaram casos no Brasil. Dos 162 prováveis casos, os maiores registros foram nos estados da Bahia (51) e Amazonas (25), de 2008 a 2021, os casos em ambientes marinhos iniciaram-se em outubro, enquanto os casos no Amazonas, em junho. Espécies de peixes marinhos e dulcícolas foram relacionados à doença com sintomas iniciados em até 24 horas após o consumo dos peixes com duas hipóteses consideradas para possível confirmação do agente etiológico e/ou fatores de risco para os adoecimentos observados.  Com os dados obtidos, é possível delimitar pesquisas para territórios específicos, contemplando o conceito e a abordagem de saúde única.
Lixo e saúde:
Authors: Assis João Victor Matos de , Castro de Jesus Ana Beatriz , Maia Nayla Thaisa Gonçalves
Published: March 2024

O descarte incorreto do lixo ou resíduos sólidos corresponde a uma prática que ocasiona problemas e impactos ambientais diversos para a população local e para o meio ambiente de maneira geral. Essa prática está atrelada ao processo de formação dos bairros e principalmente pelos problemas referentes aos serviços de coleta, presença de atividades que ocasiona o espalhamento dos lixos nas ruas, acondicionamento inapropriado e a presença de lugares que passam a receber esse material sem infraestrutura recebendo a denominação popular de “lixeiras viciadas”. Para a realização desta pesquisa optou-se pelo levantamento bibliográfico concernente ao tema, com enfoque na cidade de Manaus e no bairro do Coroado, posteriormente realizou-se trabalho de campo no primeiro semestre de 2023, por meio de entrevistas abertas com moradores e funcionários dos estabelecimentos de atendimento à saúde. Identificou-se que o processo de formação do bairro foi marcado pela pressão popular com uma ocupação que não teve um ordenamento gestado pelo Estado, mas pela população civil organizada, que estabeleceu ruas e casas a partir de 1970. Além disto, nota-se aspectos geográficos e de saúde que remetem pelos problemas centrados no descarte incorreto do lixo ocasionando impactos diversos para a população local e ao meio ambiente em geral.
Applying The Constructivist Activities on Teaching English Literature (A Study is Conducted in Literature Class of English Education Department of Universitas Negeri Manado)
Authors: Sabudu Delli
Published: March 2024

The aim of this research is to find out whether the constructivist theory is effective to enrich students’ mastery of literary work or not. This research is classified as quantitative research which is true experimental design, the data collected in the form of numbers and the data statistically analyzed. In this research, the writer used a sample of students in the parallel class of English Education students in the 3th semester who had learned the subject of Introduction to Literature. One class randomly chosen from 4 clasess as the experimental class and control class and the t-test observe used in analyzing the data. The research finding shows that students were given a pre-test to what extent they understood about English Literature, from the results obtained, it was known that there were differences in mastery of the field of literature in each individual. Then, the students are given treatment using the constructivist theory referring to the students' learning experiences about the work of English Literature, given exposure and then post-test results which can show the experimental group gets the majority of scores higher than the control group. This means that there are significant differences between students' interest in learning about English Literature has increased in mastery of the topic and the overall phenomena that accompany it. In other words, students who are taught using Constructivist theory master the topic or material better, even they can enjoy the learning process more than Students who are not taught using Constructivist theory
Pain Pleasure Principle in Joy Harjo's Poetry: The Foundation of Personal Choices and Identity
Authors: Glayl Mohanad Ghanim
Published: March 2024

This article examines Joy Harjo’ journey, the renowned poet and musician, has navigated a tumultuous life filled with pain and adversity. The pain pleasure principle is a fundamental aspect of human decision-making. Beliefs, values, actions, and decisions are all shaped by this principle, but it is crucial to examine them critically through a postcolonial lens to better understand the power dynamics and social structures that influence our interpretation of pain and pleasure. A lot of studies have been conducted on Indigenous literature, but very little has delved into the exploration of pain and pleasure, specifically in the works of Joy Harjo. However, the current study argues that when examining Indigenous literature, it is essential to approach it through the lens of post-colonial theory and consider concepts such as identity, hegemony, and hybridity in order to fully understand the hidden motives behind these literary works. In her literature, Harjo's poetry serves as a testament to the transformative nature of language and its ability to heal. Harjo's work, particularly her book "Conflict Resolution for Holy Beings," emphasizes the importance of language in bridging cultural and linguistic gaps. Joy Harjo ‘literature reflects the pleasure serves as a driving force in our lives, motivating us to make certain choices and take specific actions. These choices and actions, in turn, shape our individuality and help us develop a unique identity. The study stresses on Pain pleasure principle that plays a crucial role in Indian American literature, particularly evident in the works of Joy Harjo