bluuebunny/crossref_metadata_2025 huggingface dataset:
Development of Mucoadhesive Patches for Buccal Administration of Prochlorperazine: Evaluation of In Vitro Release and Mechanical Properties
Authors: Kolli Chandra Sekhar , Gannu Ramesh , Yamsani Vamshi Vishnu , V Kishan , Yamsani Madhsudan Rao
Published: August 2020

The aim of this investigation was to develop and evaluate mucoadhesive buccal patches of prochlorperazine (PCPZ). Permeation of PCPZ was calculated in vitro using porcine buccal membrane. Buccal formulations were developed by solvent-casting technique using hydroxy propylmethyl cellulose (HPMC) as mucoadhesive polymer. The patches were evaluated for in vitro release, moisture absorption and mechanical properties. The optimized formulation, based on in vitro release and moisture absorption studies, was subjected for bioadhesion studies using porcine buccal membrane. In vitro flux of PCPZ was calculated to be 2.14 ± 0.01 µg. h–1.cm–2 and buccal absorption was also demonstrated in vivo in human volunteers.             In vitro drug release and moisture absorbed was governed by HPMC content. Increasing concentration of HPMC delayed the drug release. All formulations followed Zero order release kinetics whereas the release pattern was non-Fickian. The mechanical properties, tensile strength (10.28 ± 2.27 kg mm–2 for formulation P3) and elongation at break reveal that the formulations were found to be strong but not brittle. The peak detachment force and work of adhesion for formulation P3 were 0.68 ± 0.15 N and 0.14 ± 0.08 mJ, respectively. The results indicate that suitable bioadhesive buccal patches of PCPZ with desired permeability and suitable mechanical properties could be prepared
pH Sensitive Liposomes Enhances Immunogenicity of 19 kDa Carboxyl-terminal Fragment of Plasmodium Falciparum
Authors: P. Vyas Suresh , S. Jadon Rajesh , K. Goyal Amit , Mishra Neeraj , N. Gupta Prem , Khatri Kapil , Tyagi Rajeev
Published: August 2020

The Carboxyl-terminal 19 kDa fragment of merozoite surface protein-1 of Plasmodium falciparum (PfMSP-119) was delivered directly into the cytoplasm via pH sensitive liposome.  In the present study, we have reported the preparation and characterization of PfMSP-119 encapsulated pH-sensitive liposomal formulations using oleyl alcohol (OAlc) in combination with egg phosphatidylcholine (EPC) as the membrane destabilizing components. Furthermore, the OAlc-containing liposomes were evaluated for the intracellular cytosolic delivery of PfMSP-119 and as is evident from the results obtained; promising and significant immune responses were obtained by the cytosolic delivery of the malaria antigen through pH sensitive liposome and in association with alum this carrier vehicle may be used as a natural adjuvant. Moreover, after intramuscular immunization of PfMSP-119 loaded pH sensitive liposomes, into Balb/c mice, the significant and perdurable IgG responses were obtained, as compared to conventional liposome loaded with PfMSP-119 and comparative evaluations have been marked with alum adsorbed malaria antigen. This may be attributed to good immuno-adjuvant action of pH sensitive liposomes, which are reported to enhance the immunogenicity of a soluble malaria antigen and present study might open new ways for the feasibility for the development of blood stage malaria vaccine.
Development of Sustained Release Multi-Component Microparticulate System of Diclofenac Sodium and Tizanidine Hydrochloride
Authors: Dashora Kamlesh , Saraf Shailendra , Saraf Swarnalata
Published: August 2020

Sustained released tablets of diclofenac sodium (DIC) and tizanidine hydrochloride (TIZ) were prepared by using different proportions of cellulose acetate (CA) as the retardant material. Nine formulations of tablets having different proportion of microparticles developed by varied proportions of polymer: drug ratio ‘’i.e.’’; 1:9 -1:3 for DIC and 1:1 – 3:1 for TIZ. Each tablet contained equivalent to 100 mg of DIC and 6mg of TIZ. The prepared microparticles were white, free flowing and spherical in shape (SEM study), with  the particle size varying from 78.8±1.94 to 103.33±1.28 µm and 175.92± 9.82 to 194.94±14.28µm for DIC  and TIZ, respectively.  The first order rate constant K1 of formulations were found to be in the range of  K1 = 0.117-0.272 and 0.083- 0.189 %hr-1for DIC and TIZ, respectively. The value of exponent coefficient (n) was found to be in the range of 0.6328-0.9412  and 0.8589-1.1954 for DIC and TIZ respectively indicates anomalous  to  non anomalous transport type of diffusions among different formulations
Design, Synthesis and H1 - Antihistaminic Activity of Novel Thieno [2, 3-d] pyrimidinones
Authors: B Shireesha , K Uma Shankar , A Raghuram Rao , KS Rajan , M Raghuprasad
Published: August 2020

Some of the fused pyrimidinones were reported from our laboratory with antihistaminic and bronchodilatory activities. As part of our ongoing research programme on the potential utility of thienopyrimidines, a novel series of compounds were designed based on the general pharmacophore model for H1- antihistaminic agents. The designed molecules were synthesized and evaluated for antihistaminic activity and anticholinergic activity. Various descriptors like HOMO (Highest Occupied Molecular Orbital), LUMO (Lowest Unoccupied Molecular Orbital) and clogP that can influence the sedative and anticholinergic activity of the molecules were computed while designing the molecules using Chem Office-2008. All the virtual screening data was correlating with the experimental values.
Hepatoprotective Activity of Calotropis gigantea Root Bark Experimental Liver Damage Induced by D-Galactosamine in Rats
Authors: Deshmukh Pradeep , Nandgude Tanaji , Rathode Mahendra Singh , Midha Anil , Jaiswal Nitin
Published: August 2020

The suspensions of alcoholic extract of root bark of the plant Calotropis gigantea in 0.6% carboxy methyl cellulose (CMC) were evaluated for hepatoprotective activity in Wistar albino rats by inducing hepatic injury with D-galactosamine (400 mg/kg). Alcoholic extract of root bark of the plant Calotropis gigantea at an oral dose of 200 mg/kg and 400 mg/kg exhibited a significant (P<0.001, P<0.01 and P<0.05) protection effect by normalizing the levels of aspartate amino transferase (ASAT/ GOT), alanine amino transferase (ALAT/GPT), alkaline phosphatase (ALP), total bilirubin (TB), lactate dehydrogenase (LDH), which were significantly (P<0.001) increased in rats by treatment with 400 mg/kg i.p. of D-galactosamine. Silymarin (25 mg/kg), a known hepatoprotective drug used for comparison exhibited significant activity (P<0.001).
Dissolution Enhancement of Domperidone Using Water Soluble Carrier by Solid Dispersion Technology
Authors: Venkatesh D. Nagasamy , Sangeetha S. , Samanta M.K. , Suresh B. , Ramesh N. , Faisal M. Mohamed , Ilahi A. Asik , Abuthahir K.S. Syed , Haq K.B.M.I. , Elanthirayan S.
Published: August 2020

Domperidone is a highly water insoluble drug exhibiting poor dissolution pattern. This is the cause for its poor absorption. Currently, several products of this drug substance is available in the market. Solid dispersions of domperidone were prepared using different ratios of polyvinylpyrrolidone as carrier by kneading method. They were evaluated for drug content, intactness of the drug in the formulation and dissolution. IR spectral and DSC studies were used to characterize the solid dispersion and to study the possibility of complexation of drug with carrier. The dissolution of domperidone from the solid dispersions exhibited higher rates of dissolution and dissolution efficiency values over that of pure drug
Supercritical Fluid Technology- An Unlimited Frontier in Herbal Research
Authors: Vyas Niraj , Khan Mohammad Yaseen , Panchal Siddharth , Butani Amee , Kumar Vimal
Published: August 2020

Supercritical fluid technology is a process using a supercritical fluid as a solvent. When a fluid is taken above its critical temperature (Tc) and critical pressure (Pc), it exists in a condition called the supercritical fluid state. The physico-chemical properties of a fluid in the supercritical state are in between those of a typical gas and liquid. Due to increasingly stringent environmental regulations, supercritical fluid technology (SFT) has gained wide acceptance in recent years as an alternative to conventional solvent extraction for herbal compounds as well as in many analytical and industrial processes. This article presents the practical aspects of SFT applications in selection of modifiers, on-line offline coupling techniques. SFT can also be used to clean up pesticides from herbal medicines. Carbon dioxide is most commonly used Supercritical Fluid (SF) as it is safe, inexpensive, non-toxic, non-inflammable and inert to most of the materials as well as its solvating strength is adjusted by modifier (methanol). SFT processes can be modeled to acquire useful information for better understanding of the extraction, mechanisms and optimization of the extraction procedures. In recent years, Supercritical Fluid Extraction (SFE) has emerged as a highly promising technology for production of herbal medicines and nutraceuticals with high potency of active ingredients.
Glibenclamide Therapy in Type 2 Diabetes
Authors: M. Sai Laxmi , A. Venkatesham , Reddy A. Rama Narsimha , P. Shankaraiah , D. R. Krishna , Reddy Y. Narsihma
Published: August 2020

Glibenclamide is a second generation sulfonylurea used in the treatment of type 2 diabetes. The study included 57 type 2 diabetic patients of either sex, aged above 21 years, an who were under treatment with glibenclamide. Blood samples were collected after 2 hours of drug intake and the next day, early morning before taking the drug. Serum glucose levels and glycosylated hemoglobin levels were estimated. The effect of glibenclamide treatment on long-term glycemic control was studied. There was no correlation between peak serum drug concentrations and post prandial glucose level as well as between trough serum drug and fasting glucose concentrations as could be observed from the coefficient of correlation (R2) values of 0.0319 and 0.0013, respectively. There is no correlation between peak serum drug concentration and HbA1c% as can be observed from the R2 value of 0.0101.The insignificant correlation between the parameters indicates that upon chronic therapy with glibenclamide desensitization and receptor down regulation occurs leading to loss of glycemic control. It was observed that the increased dose of glybenclamide also did not improve glycemic control.
Hepatoprotective Activity of Cardiospermum helicacabum Stem Extracts Against Carbontetrachloride-induced Hepatotoxicity in Wistar Rats
Authors: Ara Arjumand , Reddy. K Srinivas , Reddy C.S.
Published: August 2020

Natural remedies from medicinal plants are considered to be effective and safe alternative treatments for liver toxicity. Our aim was to demonstrate the hepatoprotective effect of various extracts of Cardiospermum helicacabum (sapindaceae) stem. The various extracts of stem in arachis oil were administered orally for 7 days and the hepatoprotective activity was studied in carbon tetrachloride induced hepatic damage model in male wistar rats. The hepatoprotective activity was assessed using various biochemical parameters like serum bilirubin, protein, serum glutamic oxaloacetic transaminase (SGOT), serum glutamic pyruvic transaminase (SGPT) and alkaline phosphatase (ALP) along with histopathological studies of liver tissue. There was a significant increase in serum levels of bilirubin, SGOT, SGPT and ALP with a decrease in total protein level, in the CCl4 treated animals, reflecting liver injury. In the stem extracts treated animals there was a decrease in serum levels of the markers and significant increase in total protein, indicating the recovery of hepatic cells. These biochemical observations were supplemented by histopathalogical examination of liver section. The effects of extracts were compared with standard drug silymarin. The ethyl acetate stem extract (400mg/kg) of Cardiospermum helicacabum afforded significant protection against CCl4 induced hepatocellular injury compared to all extracts.
The Effect of Different Superdisintegrants and their Concentrations on the Dissolution of Topiramate Immediate Release Tablets
Authors: Priya V A. Vamshi , Rao G. Chandra Sekhara , Reddy D. Srinivas , Reddy V. Prabhakar
Published: August 2020

The purpose of this study was to investigate the efficiency of superdisintegrants: sodium starch glycolate, croscarmellose sodium and crospovidone in promoting tablet disintegration and drug dissolution of Topiramate immediate release tablets. The efficiency of superdisintegrants was tested, by considering four concentrations, viz., like 2%, 3%, 4% and 5% in the formulations. The dissolution was carried out in USP apparatus II at 50 rpm with distilled water as a dissolution medium. The dissolution rate of the model drug topiramate was found highly dependent on the tablet disintegration, on the particle size of the superdisintegrant, on the solubility of the drug and also on the type of superdisintegrant in the dissolution medium. There was no effect of the diluent (Lactose monohydrate) on the disintegration of different concentrations of superdisintegrants. These results suggest that, as determined by the f2 metric (similarity factor), the dissolution profile of the formulation containing 4% sodium starch glycolate and lactose monohydrate as a diluent was similar to that of a marketed product.
In-Situ Gelling System based on Thiolated Gellan Gum as New Carrier for Nasal Administration of Dimenhydrinate
Authors: Mahajan Hitendra , Shaikh Hannan , Gattani Surendra , Nerkar Pankaj
Published: August 2020

The purpose of the present study was to develop intranasal delivery system of dimenhydrinate using thiolated gellan gum and formulations were modulated so as to have gelation at physiological ion content after intranasal administration.  Gelation was determined by physical appearance.  The mucoadhesive force in terms of detachment stress, determined using sheep nasal mucosa, increased with increasing concentration of thiolated polymer. The results of in vitro drug permeation studies across sheep nasal mucosa indicate that effective permeation could be significantly increased by using in situ gelling formulation with thiolated polymer concentration.  Finally, histopathological examination did not detect any changes during in vitro permeation studies.  In conclusion the gel formulation of dimenhydrinate with in situ gelling and mucoadhesive properties with increased permeation rate is promising for prolonging nasal residence time and thereby nasal absorption.
Synthesis and Pharmacological Evaluation of New Indolyl-oxadiazoles as Anticonvulsant Agents
Authors: Rajak Harish , Veerasamy Ravichandran , Gupta Arun Kumar , Kharya Murli Dhar , Mishra Pradeep
Published: August 2020

The search for better anticonvulsant drug and the importance of 2,5-disubstituted 1,3,4-oxadiazoles and indole as anticonvulsant pharmacophores, prompted us to design, synthesize and evaluate a series of differently substituted 1,3,4-oxadiazoles for their potential anticonvulsant activity. The structures of the compounds were elucidated by elemental and spectral (IR, 1H NMR, 13C NMR and MS) analyses. Most of the test compounds demonstrated appreciable anticonvulsant activities in maximal electroshock seizure (MES) and subcutaneous pentylenetrtrazole (scPTZ) models.
Evaluation of the Antimicrobial Activity of Saponins Extract of Trianthema portulacastrum
Authors: Banu Gani Sharmila , Kumar Ganesan , Umamagesh Palaniappan , Karthikeyan Subramanian
Published: August 2020

The saponin extract of Trianthema portulacastrum were screened for anti-bacterial activity against three pathogenic microbes; Escherichia coli, Staphylococcus aureus and Candida albicans. The extract inhibited the growth of the S. aureus. It was concluded that the saponins have inhibitory effect on gram-positive organism but not on gram negative organism and the fungi.
Preliminary Phytochemical Analysis and Wound Healing Activity from the Leaves of Cocculus hirsutus Diels
Authors: Ranjan Panda Bikash , S.R Mohanta , S. Sii , G. K. Das
Published: August 2020

In qualitative phytochemical analysis of petroleum ether, chloroform and methanol extracts of the leaves of Cocculus hirsutus Diels, the important secondary plant metabolites detected are Carbohydrates, Steroids, Glycosides, Tannins, Saponins and Flavonoids. The methanol extract and fresh leaves juice are subjected to wound healing activity in incision and excision wound models taking Soframycin sulphate as standard. The results revealed that the methanol extract ointment 10%w/w has highest wound healing potency among the test groups and is comparable with the standard and thus the results offer a scientific support to the treatment of traditional healers of this region.
Studies in Optimization of Aqueous Film Coating Parameters
Authors: Sheth Navin , Shah Sunny , Potdar Arti , Shah Anand
Published: August 2020

The purpose of this research was to study the aqueous-based film coating of tablets utilizing a laboratory-scale side-vented perforated pan-coating apparatus. The process parameters of potential importance with respect to the final film quality were evaluated by using trial and error method. Tablets were evaluated for coating uniformity (mg), coating process efficiency (%), surface roughness, and %LOD (loss on drying). Spray rate and inlet air temperature both affect the all characteristic of coated tablets. Rotating speed of pan mainly affect the coating uniformity of tablets. % Solid content affects the surface of coated tablets and also creates a problem in spray flow. The process parameters relevant to a side-vented perforated pan coating process can be identified and, consequently, optimized.
Formulation and Process Optimization of Solid Dispersion of Meloxicam and PEG8000 Prepared by Spray Drying
Authors: R.P. Patel , M. P. Patel , A. M. Suthar , A.H. Baria
Published: August 2020

The poor solubility and wettability of meloxicam leads to poor dissolution and hence shows poor bioavailability. The present study is aimed at increasing solubility of drug using solid dispersion technique. The solid binary systems were prepared using different drug: polymer ratio (1:1, 1:5 and 1:10) with polyethylene glycol 8000 by different techniques like physical mixing, melting method and spray drying method. The formulations were characterized by differential scanning colorimetry, scanning electron microscopy and in vitro dissolution rate studies. The solubility of drug increased linearly with the increase in polymer concentration. The solid dispersion of drug prepared by spray drying method demonstrated higher drug dissolution rates in comparison to solid dispersion prepared by physical mixtures, melting method and pure meloxicam. Moreover, spray drying process parameters inlet air temperature and feed rate were also optimized to obtain maximum powder yield and satisfactory particle size and compressibility. The outcome indicated that with the increase in feed rate, the powder yield and Carr’s index decreases but particle size increases. On the other hand, as the inlet temperature increases, powder yield and Carr’s index increases.
Nanosuspensions: A Promising Drug Delivery Systems
Authors: P Nagaraju. , K Krishnachaithanya. , V.D.N Srinivas. , S.V.N Padma.
Published: August 2020

One of the critical problems associated with poorly soluble drugs is low bioavailability and or erratic absorption. The problem is even more complex for drugs such as itraconazole and Carbamazepine (belonging to BCS CLASS II) as they are poorly soluble in both aqueous and organic media, and for those drugs having a log P value of 2. There are number of formulation approaches to resolve the problems of low solubility and low bioavailability. But all those have some limitations and hence have limited utility in solubility enhancement. Nanotechnology can be used to resolve these problems associated with conventional approaches. Nanotechnology is defined as the science and engineering carried out in the nanoscale that is 10-9 meters. Nanosuspensions consist of the pure poorly water-soluble drug without any matrix material suspended in dispersion. A nanosuspension not only solves the problems of poor solubility and bioavailability but also alters the pharmacokinetics of drug and thus improves drug safety and efficacy
Effect of Formulation variables on Nanosuspension Containing Famotidine Prepared by Solvent Evaporation Technique
Authors: Patel Dhaval J. , Patel Jayvadan K. , Pandya Vikram M. , Patel Ritu D.
Published: August 2020

Low oral bioavailability of poorly water-soluble drugs poses a great challenge during drug development. Poorly water-soluble compounds are difficult to develop as drug products using conventional formulation techniques and are frequently abandoned early in discovery. The aim of the this study was to improve the dissolution rate of a poorly water-soluble drug famotidine, by a nanoprecipitation technique. Selected parameters of the nanoprecipitation method, such as the amount of Lutrol F-68 and stirring speed were varied so as to obtain drug nanoparticles. The combination of lowest amount of stabilizer with low speed yield bluish white transparent nanosuspensions with the smallest average particle size (566 nm). In contrast to the very slow dissolution rate of pure famotidine, the nanosuspension of the drug considerably enhanced the dissolution rate. Nanosuspension prepared with 0.25% Lutrol F-68   with 1000 rpm showed the most improvement in dissolution rate of famotidine. The formulation of famotidine as a nanosuspension was very successful in enhancing dissolution rate, more than 42% of the drug being dissolved in the first 10 min (batch F1) compared to less than 2.5% of the micronized drug (batch F7).
Preparation and Evaluation of Glipizide Tablets Containing both Enhanced and Sustained Release Solid Dispersions
Authors: Aly Adel M. , Ali Ahmed S.
Published: August 2020

: Glipizide (GZ) is an oral blood-glucose-lowering drug of the sulfonylurea class characterized by its poor aqueous solubility. Aiming for the production of GZ tablets with rapid onset of action followed by prolonged effect; GZ-Polyethylene glycol (PEG 4000 and 6000) solid dispersions with different ratios, (using melting and solvent evaporation method), as well as, coprecipitate containing GZ with polymethyl-methacrylate (PMMA) were prepared. Four tablet formulations were prepared containing; a) GZ alone, b) GZ: PEG6000, 1:10, c) GZ:PMMA 1:3, and, d)both GZ:PEG6000 1:10 and GZ:PMMA 1:3. The solvent evaporation method showed more enhancement of GZ solubility than the melting one, and this solubilizing effect increased with PEG increment. Generally, PEG6000 showed more enhancement of dissolution than PEG4000 especially at 1:10 drug: polymer ratio (the most enhancing formula). Also, the prepared tablet formulations showed acceptable physical properties according to USP/NF requirements. The dissolution results revealed that tablets containing PEG6000 (1:10) have the most rapid release rate, followed by the formula containing both PEG6000 and PMMA, while that including PMMA alone showed the slowest dissolution rate. Moreover, In-vivo studies for each of the above four formulations, were performed using four mice groups. The most effective formula in decreasing the blood glucose level, through the first 6 hours, was that containing GZ and PEG6000, 1:10. However, formula containing the combination of enhanced and sustained GZ was the most effective in decreasing the blood glucose level through 16 hours. Successful in-vitro in-vivo correlations could be detected between the percent released and the percent decreasing of blood glucose level after 0.5 hours.
Evaluation of Cassia roxburghii Seed Gum as Binder in Tablet Formulations of Selected Drugs
Authors: KSG Arul Kumaran , S Palanisamy , A Rajasekaran , Hari Ahil
Published: August 2020

The purpose of the study was to evaluate cassia roxburghii seed gum powder as binder for paracetamol and diclofenac sodium. Granules of both drugs were prepared by wet granulation method. Two different laboratory developed methods were tried for the isolation of seed mucilage from seed powder. The phytochemical, physico-chemical and microbiological properties were performed on the seed gum and the pre-compression parameters like bulk density, tapped density, angle of repose, carr’s index and hausner’s ratio have shown that paracetamol and diclofenac granules prepared using Cassia roxburghii gum were well within the limits and comparable to those prepared using standard starch paste as binder. The in vitro dissolution study was performed for paracetamol formulations with sodium starch glycolate and the dissolution profile shows all the three formulations met with official specifications. The in vitro dissolution profile shows that drug release decreased in the order, tablets prepared by starch>c.roxburghii defatted>c.roxburghii filtered in both paracetamol and diclofenac formulations. The drug release from tablets prepared by C.roxburghii seed gum was more than 85% in 2 hours and filtered C.roxburghii gum has excellent mechanical, binding and release properties in paracetamol tablet formulations with the addition of sodium starch glycolate as an external disintegrant
Formulation and Evaluation of Baclofen Orally Disintegrating Tablets
Authors: Janardhan Dumpeti , Sreekanth Joginapally , Kumar P.Theja Pavan , Krishna M.Vamshi
Published: August 2020

The purpose of this study was to evaluate the potential of polymers for masking the taste of bitter drugs when incorporated into orally disintegrating tablets. The tablets were produced by simple wet granulation technique with a model compound (baclofen) which is moderately bitter. The formulating procedure had two variables to obtain good taste masking with desirable characteristics. The optimal granulation process parameters were polymer selection and its concentration (w/w), suitable for pilot scale level. Dextrates, β- cyclodextrin, eudragit EPO and PVP K-30 were used in preparation of granules by using water and iso-propyl alcohol. Crospovidone was used intra and extra granularly as superdisintegrant.  Sodium bicarbonate and citric acid were used as effervescent for fast disintegration of tablets, which also optionally act as desensitizer of taste buds. Results from evaluation of tablets indicated a disintegration time (avg) of 30-35 sec and 100% drug release was achieved within 5 min. But taste masking was achieved by only with eudragit EPO. Results from an evaluation by a panel of six human volunteers demonstrated that the orally disintegrating tablets which are prepared by using polymer Eudragit EPO (5% and 7.5% w/w of tablet) and PVP (7.5% w/w of tablet) improved taste, significantly. On studying physical parameters, F9 formulation demonstrated acceptable level of hardness and friability with good taste masking and it was thus considered as an optimized formulation
The Scientific Value Of Research On Mirmukhsin Fikriy
Authors: Turaeva Umriniso Rahmatovna
Published: August 2020

The history of the Turkestan Jadid movement and the study of Jadid literature show that it has not been easy to study this subject. The socio-political environment of the time led to the blind reduction of the history of continuous development of Uzbek literature, artificial reduction of the literary heritage of the past on the basis of dogmatic thinking, neglect of the study of works of art and literary figures. As a result, the creation of literary figures of a certain period, no matter how important, remained unexplored.
Analisis Pengaruh Bauran Promosi Analisis Pengaruh Bauran Promosi Terhadap Tingkat Kepuasan Mahasiswa Serta Dampaknya Terhadap Citra STIE INABA Bandung
Authors: Suhendar Suhendar
Published: August 2020

STIE INABA merupakan salah satu sekolah tinggi di Bandung yang telah cukup lama berdiri dan sampai saat ini terus meningkatkan pelayanan dan promosi melalui saluran informasi tepat agar capaian tingkat kepuasan bagi mahasiswa berdampak pada citra lembaga tersebut tetap baik di mata Mahasiswa, Alumni dan Masyarakat sehingga mereka akan terus merekomendasikan keluarga, teman dan rekan untuk menempuh pendidikan di STIE INABA.

Tujuan penelitian adalah untuk mengetahui pengaruh bauran promosi terhadap tingkat kepuasan mahasiswa, Bauran promosi terhadap citra, tingkat kepuasan terhadap citra dan pengaruh bauran promosi terhadap citra melalui tingkat kepuasan mahasiswa di STIE INABA Bandung.

Metode yang digunakan dalam penelitian ini meliputi; metode analisis deskriptif dan verifikatif.

Hasil penelitian dan pembahasan menunjukkan bahwa; dari hasil analisis deskriptif bahwa bauran promosi yang terdiri dari; Periklanan, Penjualan perorangan, Promosi penjualan, Hubungan Masyarakat, Word of Mouth, pemasaran langsung, Publikasi memiliki kriteria tinggi rata-rata (73,09%), tingkat kepuasan memiliki kriteria rendah (40,50%) dan citra STIE INABA memiliki kategori tinggi (73,64%). Berdasarkan hasil uji analisis verifikatif menunjukan bahwa secara simultan pengaruh bauran promosi (X) terhadap tingkat kepuasan Mahasiswa (Y) sebesar 0,045 atau sebesar 4,5% dan secara parsial, pengaruh Periklanan (X1) memberikan kontribusi sebesar 19,1%, pengaruh Word of Mouth memberikan kontribusi sebesar 7,2% dan Pemasaran langsung memberikan kontribusi sebesar 12,4%, sementara variabel lainnya tidak memberikan  kontribusi atau hasil negatif. Sedangkan uji hipotesis menunjukkan bahwa bauran promosi (X) tidak berpengaruh terhadap tingkat kepuasan Mahasiswa (Y) karena hasil Fhitung < dari Ftabel yaitu 0,562<2,121. Pengaruh Bauran promosi (X) terhadap citra (Z) signifikan dengan hasil Fhitung > dari Ftabel yaitu 12,729 > 2,121. Tingkat kepuasan Mahasiswa tidak berpengaruh terhadap Citra dengan hasil Fhitung < dari Ftabel 1,089<2,121 sementara Pengaruh Bauran Promosi (X) terhadap Citra (Z) dipengaruhi oleh Tingkat Kepuasan (Y) signifikan dengan hasil Fhitung < dari Ftabel yaitu 11,310 > 2,121 dengan tingkat signifikansi 0,05.
PENGARUH TINGKAT KEPATUHAN WAJIB PAJAK TERHADAP PENERIMAAN PAJAK
Authors: Rakhmadhani Vania
Published: August 2020

Ratio Kepatuhan Penyampaian SPT PPh DJP Tahun 2008-2015 menunjukan adanya kesenjangan yang cukup jauh antara jumlah wajib pajak terdaftar dengan penyampaian SPT Tahunan PPh. Tujuan dari penelitian ini adalah untuk menguji pengaruh tingkat kepatuhan wajib pajak terhadap penerimaan pajak. Populasi dalam penelitian ini adalah wajib pajak yang terdaftar pada Direktorat Jenderal Pajak. Sampel yang digunakan adalah dari tahun 2008-2015. Metode penentuan sample yang digunakan adalah sampel probabilitas. Sedangkan metode pengolahan data menggunakan analisis regresi linier sederhana. Hasil pengujian hipotesis yang dilakukan menunjukkan bahwa tingkat kepatuhan wajib pajak berpengaruh terhadap penerimaan pajak.
Pengaruh Jaminan Kesehatan Kerja Dan Kompensasi Finansial Terhadap Motivasi Kerja Pegawai (Studi Pada Dinas Pemadam Kebakaran Dan Penanggulangan Bencana Kota Bandung)
Authors: Hakim Lukman
Published: August 2020

ABSTRACT: Human resources' existence plays a significant role in the success of a company, so many companies realize that human resources in the company can provide a competitive advantage. In the company of labor is the motor of the company, the assets of the company, which is an investment for a company to increase productivity. As a company asset, the welfare guarantee given by the company to workers or employees is an obligation that must be adjusted to their needs. Also, to realize the goals of the company, of course, there needs to be compensated as one of the motivations for employees

In this study, the author used a research method based on descriptive statistics with a quantitative approach. The sample in this study consisted of 30 employees of the Bandung City Fire Department. The analysis used was multiple regression analysis.

Based on the results of the study, it was found that the Occupational Health Insurance and Financial Compensation jointly had an effect of 85.8% on employee work motivation. The remaining 14.2% caused

 

ABSTRAK: Keberadaan sumber daya manusia memiliki peranan besar bagi kesuksesan sebuahperusahaan, sehingga banyak perusahaan menyadari bahwa unsur manusia dalam perusahaan itu dapat memberikan keunggulan daya saing. Di dalam perusahaan tenaga kerja merupakan motor penggerakperusahaan, aset perusahaan yang merupakan investasi bagi suatu perusahaan untuk meningkatkan pruduktivitas. Sebagai aset perusahaan, maka jaminan kesejahteraan yang diberikan oleh perusahaan terhadap buruh atau karyawan adalah kewajiban yang harus disesuaikan dengan kebutuhannya. Selain itu guna mewujudkan tujuan perusahaan, tentu perlu adanya kompensasisebagai salah satu motivasi bagi para karyawan

Dalam penelitian ini Penulis menggunakan metode penelitian berdasarkan statistik deskriptif dengan pendekatan kuantitatif, sample dalam penelitian ini sebanyak 30orang pegawai Dinas Pemadam Kebakaran Kota Bandung, analisis yang digunakan yaitu analisis regresi berganda.

Berdasarkan hasil penelitian diketahui Jaminan Kesehatan Kerja Dan Kompensasi Finansial secara bersama-sama berpengaruh sebesar 85,8% terhadap motivasi kerja pegawai. Adapun sebesar 14,2% sisanya disebabkan oleh variabel-variabel lain diluar variabel tersebut yang tidak dilibatkan dalam penelitian ini.
Fenomena Penggunaan Kayu pada Rumah Tradisional di Tepus, Gunungkidul, D.I Yogyakarta
Authors: Ismoyo Anggoro Cipto , Wibowo Satrio Hasto Broto
Published: August 2020

Penelitian ini bertujuan untuk menggali konsep dan nilai-nilai lokal tentang fenomena penggunaan kayu pada rumah-rumah tradisional di Tepus, Gunungkidul, Daerah Istimewa Yogyakarta. Pendekatan penelitian yang digunakan adalah fenomenologi. Dalam prosesnya, peneliti terlibat langsung di lapangan untuk mengenali, menggali, dan mengumpulkan informasi sebanyak mungkin dari objek maupun sumber-sumber informasi di lapangan, sehingga ditemukan tema-tema. Tema-tema tersebut kemudian dianalisis kedalam kategori-kategori sehingga dapat dikenali pola-pola umumnya untuk diintepretasikan dalam suatu konseptualisasi melalui generalisasi untuk memperoleh tujuan penelitian. Hasil penelitian menunjukkan bahwa fenomena tentang penggunaan kayu pada rumah tradisional di Tepus dipengaruhi oleh nilai-nilai ekonomis, pengetahuan lokal, dan religi.
Pemanfaatan Air Kelapa dan Aplikasi Pupuk Organik untuk Merangsang Pertumbuhan Bibit Tebu G3 Hasil Kultur Jaringan
Authors: Durroh Badiatud , Winarti Yayuk
Published: September 2020

Penelitian ini bertujuan untuk mendapatkan jenis pupuk organik dan kosentrasi penyemprotan air kelapa yang memberikan pertumbuhan terbaik pada tanaman tebu G3 Hasil kultur jaringan. Penelitian dilaksanakan di Kebun Penelitian KPTR Manis Harum Kab. Pasuruan . Penelitian dilaksanakan pada bulan September 2018 sampai Desember 2018. Racangan percobaan menggunakan rancangan faktorial yang diatur dalam rancangan acak lengkap (completely randomized design) yang terdiri atas dua faktor yaitu jenis pupuk (P), konsentrasi air kelapa (K). Data dianalisis dengan sidik ragam (analysis of variance).  Apabila ada beda nyata maka dilanjutkan dengan uji jarak berganda (Duncan’s Multiple Range Test) pada jenjang nyata 5%. Hasil penelitian menunjukkan bahwa.pada  perlakuan berbagai jenis pupuk organik dan konsentrasi penyemprotan air kelapa menunjukkan adanya interaksi pada parameter berat segar daun. Berat  segar daun tertinggi dihasilkan oleh perlakuan kompos sebesar  327,16 gram dengan perlakuan penyemprotan air kelapa dengan konsentrasi 100ml/l, tetapi pada perlakuan lain juga terdapat rerata yang berbeda tidak nyata. Perlakuan kompos sebesar 246,50 gram dan kotoran sapi sebesar 302,66 gram menunjukkan interaksi yang nyata pada perlakuan penyemprotan air kelapa  kontrol (tanpa penyemprotan).
Application of Cow Manure, Urea and NPK Fertilizer Combination on the Growth of Palm Oil (Elaeis Guineensis Jacq) in Pre-Nursery
Authors: Setyawan Heri , Rohmiyati Sri Manu , Purba Jhon Hardy
Published: September 2020

Seedling performance is a prerequisite for successful palm oil cultivation. Determining the growth of seedlings in addition to genetic factors can also be influenced by the provision of nutrients at the beginning of growth. This research was conducted with the aim to get the best combination of cow manure with urea and NPK on the growth of oil palm seedlings in pre-nursery. This experiment used a factorial design, consisting of a single factor arranged in a completely randomized design (CRD), which is a combined application of cow manure, urea fertilizer and NPK fertilizer consisting of 4 combination levels (0.4 g urea + 0.4 g NPK; 0.2 g urea + cow manure fertilizer, 0.2 g NPK + cow manure fertilizer, and 65 g cow manure fertilizer). Research data was analyzed using Analysis of Variance (ANOVA) at 5% significance level. The results showed that administration of a combination of 0.2 g urea + 40 g cow manure produced the best growth of oil palm seedlings, although it had the same effect as a combination of 0.4 g NPK fertilizer + 50 g cow manure, whereas the combination treatment of 0.4 g urea + 0.4 g NPK fertilizer and 65 g cow manure treatment resulted in lower growth of oil palm seedlings.
UN PROYECTO DE MODERNIDAD LA ESPAÑA RESTAURACIONISTA
Authors: Dorca Toni
Published: August 2020

Sin información.
ANTIESCLAVISMO E INDEPENDENTISMO EN CECILIA VALDÉS
Authors: Andrés Gil Carlos M.
Published: August 2020

Sin información.
Minat Berwirausaha Sosial Dikalangan Mahasiswa
Authors: Jadmiko Purbo
Published: September 2020

ABSTRACTThis study aims to determine the direct effect of empathy and social support on the social entrepreneurship intention at Bung Hatta University students. A total of 208 samples were used in this study. The results of research testing show that empathy has no effect on interest in social entrepreneurship. While social support shows a positive and significant effect on social entrepreneurial interest. Discussions on the model of forming social interest in entrepreneurship among students were discussed in this study.
The Impact of Artificial Intelligence Techniques on the Entrepreneurship of the Leadership of International Business Organizations – A Suggested Model - An Analytical Study
Authors: Alhawamdeh Dr. Tharwat , Munim Dr. Osama Abdul , Alzoubi Mohammad Omar , Alhawamdeh Hamzeh
Published: August 2020

Entrepreneurial leadership with a pure intellectual starting point has received the attention of high-quality international business organizations because of its need for leadership that possesses strategic thinking which can change with the changing circumstances surrounding it, hence the interest in the topic of entrepreneurial leadership with strategic thinking due to the acceleration of the complex environmental conditions surrounding these organizations, represented by the emergence of the phenomenon of globalization and the cognitive economy and technological progress, which may be represented here as the techniques of artificial intelligence, which prompted these leaders and their organizations to search for mechanisms for their continuity and stability in a competitive world. Therefore, it is expected that entrepreneur leaders possess the qualities of intellectual stimulation, which is an important matter in entrepreneurial leadership, and that they are also ready to change the existing status of their organizations by creating major changes, through taking advanced technological technologies. This is expected to help them achieve the visions of their organizations to reach local and global entrepreneurship. Therefore, the current study worked on knowing the impact of artificial intelligence on the entrepreneurship of the leadership of international business organizations to reach the added value of its strategic operations at the local and global levels.
Comparative Study between Open Fistulectomy and Ligation of Intersphincteric Fistulas Tract (LIFT) Procedure for Uncomplicated Perianal Fistula
Authors: Ovi Dr. Mir Rasekh Alam , Nasrin Dr. Shamima , Khalil Dr. Md. Musab , Chowdhury Dr. Farhan Imtiaz
Published: August 2020

A new sphincter-saving procedure involving the ligation of the intersphincteric fistula tract (LIFT) procedure was recently described by Rojanasakul et al from Thailand. The main concept in the LIFT is to identify the fistula tract in the intersphincteric space and the subsequent ligation and division of the tract. Some studies abroad have shown a considerably high success rate in terms of wound healing and absence of incontinence in treating fistula-in-ano by this procedure. This study aimed to compare between the earlier fistulectomy and this new innovative LIFT technique. The study was designed as a comparative type of observational study conducted at Dhaka Medical College Hospital, Dhaka and Popular Medical College Hospital from January 2014 to December 2014. Study was carried out on 40 hospital admitted patients with uncomplicated Fistula-in-ano, irrespective of age and sex. LIFT and fistulectomy was the procedure as operative treatment for their disease. Outpatient follow-up was undertaken. In our study, 30 (75%) male and 10 (25%) female patients were operated with a male to female ratio 3: 1. Mean age was 37.3 years. Vast majority of the cases i.e 23 fistula (68%) was inter-sphincteric type and the rest 17 (32%) were trans-sphincteric type. Fistulectomy took less time than LIFT. Spinal Headache was the most common complication 7.5% (3 cases). No difference was found in comparison to wound healing. (p =00.18). LIFT was found better than fistulectomy regarding post-operative incontinence (p =0.008). LIFT was found better in term of recurrence (p = 0.04) than fistulectomy but in long term there is no difference (p=0.3). In treatment of uncomplicated perianal fistula LIFT has no benefit over fistulectomy
Clients Experiences on a Government Higher Education Institution Frontline Services
Authors: Pacapac Marlow T.
Published: September 2020

The study present the clients’ experiences on the different frontline services provided by one government run higher education institution (HEI) in Ilocos Sur, Philippines. It employed a descriptive survey research design utilizing qualitative approach with a self-structured survey instrument. The participants of the study were graduates of the HEI under study. The participants were selected thru purposive sampling. Findings of the study reveals that the Higher Education Institution In Ilocos Sur under study is efficient in the delivery of services and provides satisfactory service to its clientele. However attitudinal problem on some frontline service personnel and poor records handling of some frontline service offices of the HEI needs re-assessment to take necessary measure to address the issues. It is recommended that the management should consider the problems observed and should take necessary mechanisms to improve the satisfaction to its clientele, particularly on for the personnel, reorientation and reflection for development in their attitudes, skills and total personality focusing on clients delight and satisfaction may be undertaken; and systematic records keeping and updating of documents must be undertaken by the frontline service offices.
Physicochemical and Microbiological Analysis of Drinking Water in Al Kamleen City, Gezira State
Authors: Agib Tahani H., Al , Mututali Elnasri M.
Published: September 2020

The study was carried out in Al Kamleen City in Gezira State in central Sudan, to evaluate the drinking water quality by looking into physicochemical and micro-biological aspects. Ten samples of water were collected randomly from different sites in the city and examined for electrical conductivity (E.C.), turbidity, pH and total dissolved solids (TDS). The samples were also examined for the presence of microorganisms during winter, summer and autumn. Results showed that most of the parameters examined were within the limit of the Sudanese standards and Metrology Organization (SSMO, 2015) and the World Health Organization (WHO, 2007). Some samples were contaminated by bacteria including coliform, Escherichia coli and salmonellas and the higher contamination was in autumn.
Therapeutic Applications of Chondroitin Sulphate, Collagen and Rosehip Extract in the Musculoskeletal System
Authors: Kwatra Bharat , labs Invenzion
Published: September 2020

The present review is based mainly on papers published between 2000 and 2020 and gives information about the properties of the Chondroitin sulphate, Collagen and rosehip Extract in chemical and biological systems and its possible role in preventing Musculoskeletal system diseases. The main aim of this report is to highlight their role and therapeutic applications in the Musculoskeletal system, also reported are their bioactive properties which may influence the development of treatments and protection against Musculoskeletal system cell damage. The paper will also examine recent observations in various fields
Oyster Mushroom (Pleurotus pulmonarius) Production Using Different Substrates Under 27.30C Average Temperature
Authors: Magolama Alifahmie A. , Griengo Sheila G. , Bandera Abdani D.
Published: September 2020

The study was conducted in an average temperature of 27 0C. Objectives were to determine the yield performance of oyster mushroom using different substrates and substrates’ combination; to determine if there is a significant difference on the yield performance of oyster mushroom using different substrates and substrates’ combination; and to identify which of the different substrates and their combination performs best in oyster mushroom production. The experiment was laid out using Completely Randomized Design (CRD) with an area of 30m2 . Four treatments were used and replicated five times. Sawdust, corn cob and rice straw were the substrates used in this study. Treatments were: T1 (100% rice straw), T2 (100% corn cob), T3 (100% sawdust), and T4 (33.33% rice straw + 33.33% corn cob + 33.33% sawdust). Results of the study showed that there was a highly significant difference on the average number and total number of oyster mushroom during the first harvest. However, the average weight and total weight of oyster mushroom were not significantly different. The average number, average weight, total number, and total weight were not significantly different during the second to fifth harvest. Based on the results of the study, the adoption of T3 to obtain more number of oyster mushroom per fruiting bag per treatment is highly recommended to improve the production in the locality.
The Key Success Criteria for University Students Who Are Studying While Working
Authors: Hasnun Nurul Izzati Binti , Mustaffa Dr. Nurakmal Binti Ahmad
Published: September 2020

This research primarily seeks to identify the criteria of a successful student who is studying while working and developed a framework of guidelines on how to become a successful student for an individual who is studying while working with the criteria. A survey questionnaire collected the total data of 354 and the respondents were selected using convenience sampling. For the analysis, exploratory factor analysis (EFA) was employed to determine the correlation among the variables in a data set and provides a factor structure. The result showed that three main criteria of success student have been determined, namely as Academic Preparation, Individual Trait and Support System.