bluuebunny/crossref_metadata_2025 huggingface dataset:
Analisis Pelaksanaan Kerjasama Penjaminan Pembiayaan Bank Syariah Di PT. Jaminan Pembiayaan Askrindo Syariah Kc Medan
Authors: Kiafsy Agstiamy Sitorus  , Atika
Published: January 2023

Penelitian ini bertujuan untuk mengetahui pelaksanaan kerjasama penjaminan pembiaayan bank syariah yang dilakukan oleh PT Penjaminan Pembiayaan Askrindo Syariah dalam menjalin kerjasama yang sesuai dengan ketentuan-ketentuan masing-masing antara penjamin dan terjamin yaitu kafil dan makful lahu. Kedua belah pihak inilah yang menjadikan dasar penting utama jika terjadi pelaksanaan kerjasama dengan menyetujui Lampiran Perjanjian Kerjasama dengan mengunjungi bank-bank syariah yang mana memang sudah mendapatkan data tujuan dari pusat lalu di proses di Kantor Cabang yang memang mampu melaksanakan suatu kerjasama. Sebelum dilakukannya perjanjian itu diperlukan analisis dalam pencapaian yang diharapkan agar kerjasama itu dapat terjadi, analisis seperti memenuhi kriteria yang ditentukan lalu harus memiliki prinsip syariah dan mencegah kesalahpahaman yang bisa saja terjadi dan yang terakhir tidak terikat dalam undang-undang penjaminan atau terlibat dalam suatu masalah karena akan menghambat pencairan dana yang diinginkan. Nah, Pencairan dana yang dimaksud juga tidak sembarangan disesuaikan dengan capaian kerjasama misalnya dalam produk-produk tertentu. Apabila dalam Mitra Guna Konsumtif itu sendiri tidak dapat dicairkan dan Produktif Konsumtif disini pencairan yang terjadi dapat dilakukan dengan tujuan memajukan UMKM yang dimiliki agar lebih maju lagi. Lampiran yang di perlihatkan memang sesuai dengan sistem yang ada di pusat dan lamgsung di konfirmasi oleh BPRS kerjasama lembaga keuangan syariah. Penyerahan Perjanjian Kerjasama juga dilakukan oleh Direksi dengan Direksi tanpa perantara lainnya karena memang bersifat Penting. Pelaksanaan Perjanjian Kerjasama Pembiayaan Bank ini diharapkan memajukan dan menguntungkan kedua belah pihak serta menjalin silaturahmi sesuai prinsip syariah.
Dedicatorias
Authors: Vannini Angelo
Published: January 2023

Entre la creación poética y la reflexión especulativa, Dedizioni traza un itinerario de lugares, memorias y textos buscando las motivaciones que animan la experiencia de escribir, la relación que los poetas tienen con el lenguaje y el contenido más esquivo de ese gesto primordial que es el nombrar. El autor convoca a algunos de sus amigos insustituibles, entre ellos la escritora francesa Hélène Cixous, la poeta quebequense Nicole Brossard, los poetas italianos Giovanni Raboni y Francesco Scarabicchi, los escritores italianos Dolores Prato y Alberto Savinio.
Entre le Néant et la Mort
Authors: Oliai Simon F.
Published: January 2023

Inspiré par des analyses décisives de penseurs aussi dissemblables que Nietzsche, Heidegger, Althusser et Foucault, nous avons tenté d’esquisser un cadre théorique réaliste dans lequel le phénomène mal compris de l’intégrisme contemporain puisse être interprété comme un phénomène au sens existentiel de ce terme. C’est-à-dire, comme une réalité phénoménale qui affecte l’existence de l’individu moderne dans sa contingence historique. Laquelle présuppose et met en relief l’incontournable fragilité métaphysique de l’homme en tant qu’être mortel. Un être («Dasein») dont l’existence se laisse souvent restreindre et appauvrir par la fuite permanente de la mort. Une fuite dont le questionnement critique lui ouvre («Erschliessen» au célèbre sens heideggérien dans Sein und Zeit) l’horizon de sa singularité finie. La fonction de l’idéologie intégriste est conçue, suivant la critique d’Althusser, comme l’assignation de l’homme à une «résidence fixe». Autrement dit, un cadre conceptuel rigide dans lequel une «onto-idéologie» intégriste persécute «l’Être» mortel qui se laisse persécuter («Sich Nachstellen des Seins») comme le souligne Heidegger dans sa Conférence de Brême «Le Danger» («Die Gefahr»). Sauvegarder notre monde de l’intégrisme présuppose donc un nouvel «art». Un «art» dont la pratique reflète un mouvement de liberté d’être dont la valorisation universelle est la principale tâche de la philosophie contemporaine.
Prelim
Authors: Africa Development
Published: January 2023

Prelim
‘Ghanaian first’: Nationality, Race and the Slippery Side of Belonging for Mixed-Race Ghanaians
Authors: Geoffrion Karine , Oduro Georgina Yaa , Prah Mansah
Published: January 2023

This article explores the multifaceted ways in which race impacts on processes of identification with the Ghanaian nation for mixed-race Ghanaians. Using a constructionist approach to identity, which highlights the agency of actors, the article underscores the shifting and racialising nature of national identity in transnational contexts. The article argues that whether they were born and raised in Ghana or they grew up in a Western country, mixed-race Ghanaians mainly identify as ‘Ghanaian first’. Their affiliation to Ghana stems both from growing up in the country and from being identified as black outsiders in countries of the white Western world. In both contexts, identifying as a Ghanaian is a source of pride and empowerment. However, their membership of the Ghanaian nation is often contested in their everyday life by the majority black-identified Ghanaian population, based on ethnoracial (non)authenticity premises. As such, mixed-race Ghanaian participants actively shape their Ghanaianness to justify their right to belong.
Enjeux de la pédagogie contrastée de l’histoire dans les sous-systèmes anglophone et francophone pour les politiques mémorielles au Cameroun
Authors: Ngo Nlend Nadeige , Lado Ludovic , Oukouomi Gishleine , Etah Ewane , Acha Eric
Published: January 2023

Reposant sur la collecte des données empiriques et sur la recherche documentaire, l’article compare l’enseignement de l’histoire du Cameroun dans les sous-systèmes francophones et anglophones à partir de l’analyse de supports pédagogiques et didactiques variés. Il questionne la place que revêt le Cameroun dans la discipline historique de niveau secondaire ainsi que la manière dont y sont traitées certaines séquences de son passé. Si les programmes d’histoire du premier cycle que partagent les deux sous-systèmes mentionnent bien le Cameroun à certains niveaux d’enseignement, le volume horaire ainsi que l’ampleur des sujets traités sont de loin plus élevés dans le sous-système anglophone. Par ailleurs, alors que les manuels d’histoire, limités au premier cycle dans le sous-système francophone, font l’impasse sur les thématiques relatives à la construction de l’État du Cameroun, les manuels anglophones inscrits au premier cycle et au second cycle y consacrent de larges extraits. Sans toutefois postuler une relation de cause à effet, l’article tente une exploration des enjeux de cette pédagogie contrastée pour les politiques mémorielles au Cameroun, au coeur du réveil d’un protonationalisme anglophone qui donne lieu à des relectures contrastées de l’histoire du Cameroun.
Age and Education Effects in the First Demographic Dividend of Bangladesh: A Decomposition Analysis
Authors: ISLAM SHAHIDUL
Published: January 2023

The paper attempts to examine the economic effect of changing age structure in Bangladesh in the demographic dividend while being cautious of aggregation bias. One of the major contributions of this paper to the estimation of the demographic dividend literature is its use of a disaggregated dataset to produce a representative estimation of demographic dividend and compare among different education groups. The findings of the paper shed light on the debate on the sources of the first demographic dividend—whether this dividend comes from a pure age structure factor or represents an education dividend. When the economic profiles are disaggregated by levels of education, the Economic Support Ratio (ESR) decreases compared to the estimates when it only classified by ages. After estimating the first demographic dividend, the paper disaggregates the dividend into education effect and age effect using the Das Gupta decomposition technique. Results show that the size of the dividend is driven largely by age effects, while the education effect has been negative in Bangladesh for the past decades. The negative education effect indicates the aggregation bias in the estimates of support ratio if data is not disaggregated at that level.
Stylized Facts of the Statistical Properties of Risk and Return of the Dhaka Stock Exchange: 1991-2015
Authors: IQBAL KAZI , SHAHANA SIBAN
Published: January 2023

While the role of financial market, particularly the stock market, in promoting economic growth through efficient allocation of capital is well recognised, the investors of the developing economies have little knowledge about the return and risk of the markets they operate in. To this end, we compile a security level historical data for the period 1991-2015 for Dhaka Stock Exchange and identify some important stylized facts about the return and risk. Descriptive statistics of disaggregated stock data suggest that while the daily rate of returns swing up and down over decades, the volatility tends to increase over time. Manufacturing stocks outperform other sectors both in return and volatility. Similarly, older stocks earn better return with lesser risks than the newer stocks. Several standard tests confirm that the distribution of daily returns is not normal; it does not follow random walk and the market is not efficient. Overall, there is a risk return trade-off and this trade-off varies significantly with sectors, age and quality of the stocks.
A profile of journals of complementary and alternative medicine
Authors: Schmidt K. , Pittler M. H. , Ernst E.
Published: January 2023

An increasing amount of medical scientific information is published in specialised journals on various subjects, including complementary and alternative medicine (CAM). There are indications that positive findings may be published at the expense of methodological rigour. The aim of this investigation was to provide a profile of CAM journals currently available on Medline, and monitor trends in publication practice between the years 1995 and 2000. Systematic literature searches were performed to identify all CAM journals indexed in Medline. Journals published in 1995 and 2000 were identified by their title and content. Primary CAM research journals only were included in this analysis. All articles were read, data were extracted and categorised according to pre-defined criteria, e.g. type of methodology used, subject area, and direction of outcome. The number of original articles increased from a total of 61 in 1995 to 97 in 2000 across all four journals, the number of papers reporting clinical trials decreased by 4% between 1995 and 2000, and the number of surveys increased more than six times. Less positive and more negative articles were published in 2000 compared with 1995. The subject areas of papers varied greatly. The majority of articles published in 1995 suggested positive treatment effects, a phenomenon that was still present in 2000 albeit less strong. CAM journals, and most likely CAM itself, are associated with a lack of clinical trials and a bias in favour of positive conclusions.
Kur’an Vahyinin Mahiyeti ve Nüzûl/İnzâl Keyfiyeti Üzerine
Authors: Öztürk Mustafa
Published: January 2023

Kur’an vahyinin mahiyeti ve nüzûl keyfiyeti, günümüze ulaşan kaynaklardaki rivayete dayalı bilgilerin hem kifayetsiz, hem de birçok noktada çelişkili olması sebebiyle gerçekten problemli bir konudur. Açıkça itiraf etmek gerekirse, Kur’an’ın metinleşme tarihinde ciddi boşluklar, muğlaklıklar ve tanımlamakta güçlük çekilen alanlar mevcuttur. Bilindiği üzere vahiy, vahyin mahiyeti ve nüzûl keyfiyeti gibi meseleler asırlar boyu tartışılmıştır. Kur’an’daki birçok ayette ​„vhy“ kökünden türemiş kelimelerin ​„ilham“ manasında kullanıldığı malumdur. Fakat terimsel/ıstılâhî açıdan ​„vahiy“ ile ​„ilham“ arasında kategorik bir ayrım yapılmış; ancak bu ayrımın hangi ilmî, objektif (nesnel) ölçüte dayandığı hususunda ikna edici bir argümantasyon geliştirilememiştir. Bu durum, Kur’an vahyinin mahiyeti ve nüzul keyfiyeti konusunun yeniden kritik edilmesini gerekli kılmaktadır. Kur’an vahyinin mahiyetine ilişkin geleneksel görüşler ve anlayışların kritik edilip sorgulanacağı bu çalışmada farklı bir perspektif ortaya konulacaktır.
Application of Artificial Intelligence in Image Processing of Neurodegenerative Disorders: A Review Study
Authors: Kamkar Hadi , Tayebi Seyed Moeen , Khanghahi Seyed Alireza , Kamkar Mohammad , Baghaee Arghavan , Alipour Mozhgan , Abdolmaleki Parviz
Published: January 2023

: Neurodegenerative diseases can make life difficult and lead to death in many cases. They also can be difficult, time-consuming, and costly to diagnose with enough accuracy/certainty. Artificial intelligence (AI) has shown promise in tackling some of the challenges present in medical imaging and is anticipated to become a crucial tool in health care applications in the near future. In particular, deep learning methods have displayed great performance in various subfields of image processing, including but not limited to image segmentation, image synthesis, and image reconstruction. In this paper, many state-of-the-art applications of deep learning models in image processing were reviewed.
U-Net for Medical Imaging: A Novel Approach for Brain Tumor Segmentation
Authors: Krishna Mridha  , Sourav Simanta  , Milan Limbu
Published: January 2023

In medical imaging, brain tumor segmentation is critical. The segmentation of a brain tumor might be done manually or automatically. Finding anomalies in magnetic resonance imaging (MRI) images manually is time-consuming and complex. Automatic segmentation, on the other hand, is incredibly accurate and time-saving. Any technique that can detect a brain tumor early would improve the diagnosis method. As a result, the number of cases of death will decrease. MRI (Magnetic Resonance Imaging) scans have proven to be quite helpful in the detection and segmentation of brain tumors in recent years. MRI images can aid in the detection of a brain tumor. MRI scans can detect abnormal tissue growth and blood blockages in the neurological system. The U-Net model is being used to segment the brain tumor region. The U-Net model is simply a more advanced version of CNN's algorithm. The U-Net model was created to segment biological pictures. We create a 3D U-Net design to segment the brain tumor infection zone in this paper. We combine clinical data with novel radiometric parameters based on the geometry, position, and shape of the segmented tumor to estimate each patient's survival length. The loss graph and accuracy graph are given together with the scores. Finally, we run the tests on various original photographs using the masks that correspond to them.
A study to Assess the awareness of the complication of type 2 Diabetes Mellitus and to evaluate the effectiveness of counselling program for primary prevention of Type 2 DM in young adult
Authors: Baruah Hima Dutta  , Kumar Gaurav
Published: January 2023

The rapidly increasing number of incidences, severity, its complication, and the socio-economic burden greatly demonstrate the need and importance of the preventive action for type 2 diabetes mellitus. It has been become important to emphasize the call for the primary prevention. Objectives of the study is to assess the awareness of cause complication and prevention of about type 2 diabetes mellitus among young adults, to evaluate and assess the effectiveness of a counselling program regarding causes, complication and prevention for the primary prevention of type 2 Diabetes mellitus, and to find the relationship between socio-demographical variables and level of awareness on diabetes mellitus. For this study an evaluative approach was considered. The pre-experimental design consists of pre-test and post-test observation made on different days with only one selected group and without a control group. The overall mean awareness score present in pre-test is 46.1 and the post-test 82.2% and there was enhancement of knowledge score found to be 36.4%. Therefore, it was established that there was significant increase in the awareness level after the counselling program. From this study it was found that demographic variables like educational status, family income, age group has impact on the knowledge of the respondent. The present study has demonstrated that counselling program is sufficiently effective and viable for achievement of the goal for primary prevention of Diabetes Mellitus in ordinary community
Clinical Significance of Biomarkers in Oncology and its Application in Advanced Biosensing technology- A Comprehensive Review
Authors: Sourav Das  , Sukanta Roy  , Anirbandeep Bose  , Sangeeta Choudhury  , Subhasish Mondal
Published: January 2023

cancer is the second lethal cause of human death globally and based on published literatures, approximately 9.6 million deaths accounted in 2018.1 There are several major causes of cancers: which includes, tobacco and alcohol consumption, poor hygiene less fibrous diet, lack of physical activity or some chronic infections caused by Helicobacter pylori, Human papilloma virus (HPV), Hepatitis B and C virus and Epstein-Barr virus etc.2-5According to World Health Organization report, (WHO, 12 September 2018) the most common cancers are lung, breast, colorectal, prostate, skin (non-melanoma) and stomach cancer. Aging and poor hygienic condition causes formation of free radical leading to oxidative damage to mature cells. Formation of free radicals are responsible for genomic alteration and attenuates age related oxidative damage repair mechanism in our body by suppressing different cytokines and other immunomodulaents; which is closely related to progression of different kind of cancers.6 Apart from that, different other causative mechanisms; i.e., microbial attack in host cells, viral infection, cell necrosis caused by radiations also contributes mutation in specific cells employed in the pathogenesis of different types of cancers. Among the Different therapeutic modalities of cancer, surgery has been proved to be most effective globally, before metastatic stage.7
RANCANG BANGUN CONVERTER KIT SEBAGAI ALAT KONVERSI ENERGI SEPEDA MOTOR 100cc BERBAHAN BAKAR GAS LPG
Authors: Setiawan Rizal Justian , Fitrihartanta Muhammad Sahid , Mujiono Mujiono , Nurhadiyanto Didik
Published: January 2023

LPG (Liquefied Petroleum Gas) adalah salah satu produk BBG (Bahan Bakar Gas) yang dapat digunakan sebagai bahan bakar untuk mengganti penggunaan BBM. Oleh karena itu, dibutuhkan alat konversi energi untuk memanfaatkan LPG menjadi sumber energi sepeda motor. Tujuan dari penelitian ini adalah melakukan rancang bangun converter kit motor gas. Converter kit yang dibuat ini membawa tiga teknologi yaitu sistem distribusi bahan bakarmenggunakan keran bahan bakar manual, terdapat katup solenoid yang berfungsi memutus aliran gas, dan posisi tabung bahan bakar berada dibawah jok. Metode penelitian menggunakan VDI2221 (Verein Deutcher Ingenieure). Hasil dari penelitian ini adalah terciptanya converter kits yang dibuat melalui proses desain, proses pembubutan, proses milling, proses pengelasan dan proses perakitan atau assembling. Kesimpulan yang didapatkan adalah converter kits yang telah dibuat dapat digunakan pada sepeda motor 100cc dan tidak ditemukan kebocoran ataupun kecacatan pada converter kits sehingga alat bisa digunakan secara layak pada sepeda motor 100cc.
ANALISIS SISTEM KENDALI DUA POSISI PADA SOLENOID VALVE UNTUK PRODUK BIOGAS CONTROL AND MONITORING (COMMON-BIGOT) FROM ANIMAL WASTE
Authors: Arifin Imam
Published: January 2023

Biogas adalah gas yang dihasilkan bakteri apabila bahan organik mengalami proses fermentasi dalam kondisi anaerob, dan akan menghasilkan gas Metana yang disimpan sementara pada sebuah wadah yang disebut Biogas Bag. Pada biogas bag perlu dikontrol untuk memastikan biogas bag tetap aman. Sistem kontrol tersebut berupa kontrol dua posisi karena memiliki keunggulan murah dan sederhana, selain itu solenoid valve sebagai aktuator mempunyai sifat keluaran non-linear.  Untuk mendeteksi kapasitas dari biogas bag digunakan sensor jarak HCSR-04 sebagai feedback terhadap nilai set point yang diterakan yaitu 50 cm untuk set point maksimal dan 30 cm untuk set point minimal. Hasil yang didaptakan sensor jarak mampu membaca jarak dengan ketelitian 5.8 % dan kendali On-Off mempunyai respon sebesar 0.25 detik.
PERENCANAAN PERAWATAN POMPA HIDROLIK PADA FORKLIFT 5 TON TIPE FD 50-7
Authors: Azwinur Azwinur
Published: January 2023

Kerusakan dari forklift akan menimbulkan masalah yang akan berdampak menghambat terhadap kegiatan yang lain. Sering kali hal ini diabaikan dimana alat angkat/ forklift haruslah mendapatkan perawatan yang baik dan berkelanjutan guna mempertahankan performa dari alat tersebut. Penelitian ini bertujuan untuk merencanakan perawatan berkala alat angkat (forklift) guna menghindari terjadinya kerusakan yang dapat menghentikan operasional forklift. Metode yang digunakan pada penelitian ini adalah mengumpulkan data, melakukan pengamatan langsung terhadap kerusakan yang terjadi pada pompa hidrolik, serta melakukan wawancara dengan mekanik berpengalaman yang menangani forklift tersebut. Hasil penelitian berupa perencanaan perawatan dengan metode Preventive Maintenance dan Corrective Maintenance, yaitu diterapkannya pekerjaan perawatan harian, mingguan, bulanan dan tahunan. Dalam perawatan harian akan dilaksanakan inspeksi, cek semua pelumasan dan melakukan service. Perawatan harian dilaksanakan setiap 8 jam kerja mingguan dilaksanakan setiap 60 jam kerja. Perawatan bulanan dilaksanakan setiap 250 jam kerja, sedangkan untuk perawatan tahunan dilaksanakan setiap 2500 jam kerja.
Histologic and Immunohistochemical Features of Antemortem Thrombus Compared to Postmortem Clot: Updating the Definition of Lines of Zahn
Authors: Krywanczyk Alison R. , Tan Carmela D. , Rodriguez E. Rene
Published: January 2023

Context.—

Distinguishing true antemortem thrombus (AMT) from artifactual postmortem clot (PMC) can occasionally be challenging at autopsy. Lines of Zahn are cited as pathognomonic of AMT, but review of literature reveals heterogeneous definitions of the term. Neutrophil karyorrhexis and CD61 immunohistochemistry can also be used to define AMT, but there has been no systematic study determining the specificity of these features.

Objective.—

To identify features that distinguish AMT from PMC, and to clarify the definition of lines of Zahn.

Design.—

PMC from the heart was collected in 50 hospital autopsies. Fifty arterial and 50 venous surgical thrombectomy specimens were reviewed for comparison. The microscopic features with hematoxylin-eosin staining, phosphotungstic acid–hematoxylin (PTAH) staining, and CD61 immunohistochemistry were documented.

Results.—

Thin curvilinear strands of fibrin and clumps of fibrin were frequently observed in both AMT and PMC. Thick bands of nested platelets wrapped in fibrin were nearly exclusive to AMT. Neutrophil karyorrhexis was readily apparent on low power in AMT but was seen in 40 of 50 PMCs (80%) only sparsely on high-power examination. Bone marrow elements were identified in 38 of 50 PMCs (76%). CD61 staining showed a geographic pattern in AMT and a speckled pattern in PMC. PTAH staining confirmed features seen with hematoxylin-eosin.

Conclusions.—

Thin curvilinear strands of fibrin are found in both AMT and PMC and can be misinterpreted as lines of Zahn. We define lines of Zahn as thick bands formed by nested platelets wrapped in fibrin. Diffuse neutrophil karyorrhexis is common in AMT; in contrast, bone marrow elements are often seen in PMC.
Factors related to mortality in patients with stage 5 chronic kidney disease on dialysis with COVID-19: An exploratory case series analysis
Authors: Venegas Justiniano Yanissa , Loza Munarriz César , Hurtado Aréstegui Abdías
Published: January 2023

Introduction Different studies describe the clinical profile and factors that could explain the evolution and outcome of patients with chronic kidney disease and COVID-19. This study aims to evaluate the factors related to the mortality of patients with stage-5 chronic kidney disease on chronic dialysis hospitalized for COVID-19 at the Hospital Nacional Arzobispo Loayza from April to December 2020. Methods Retrospective case series and exploratory analysis were performed. Patients with stage-5 chronic kidney disease on dialysis, older than 18 years, and hospitalized for COVID-19 disease were included. Hospital medical records were the primary data source. Results A total of 105 medical records were reviewed. 57 were male (54.3%), with a mean age of 58.6 years (standard deviation: 14.3). Eighty-four patients survived (80%), and 21 died (20%). The main cause of hospital admission, present in 80 patients (76.2%), was respiratory failure; the mean hospital stay was of 11.8 days (SD: 7.8). In the bivariate analysis: patients with moderate to severe COVID-19, overweight and obesity, increased levels of leukocytes, D-dimer, ferritin, C-reactive protein, lactate dehydrogenase, as well as, decreased levels of lymphocytes, bicarbonate and arterial oxygen pressure/inspired oxygen fraction were related to mortality risk. In multivariate analysis, only severe COVID-19 disease (OR 1.48; 95% CI 2.24 to 7.77), C-reactive protein > 10 mg/dL (OR: 9.72; 95% CI: 1.41 to 18.58), and arterial oxygen pressure/inspired oxygen fraction ≤ 150 millimeters of mercury (OR: 10.23; 95% CI: 5.87 to 36.06) were factors associated with poor survival. Conclusions In patients with stage-5 chronic kidney disease hospitalized for COVID-19, severe COVID-19 disease, C-protein reactive levels > 10 milligrams per deciliter, arterial oxygen pressure / inspired oxygen fraction ≤ 150 millimeters of mercury and severe COVID-19 disease were the main factors related to mortality.
Work and illness: a disputed relationship (20th-century Spain)
Authors: Cohen Arón , Fleta Agustín
Published: January 2023

The concepts of occupational accident, and especially of professional illness, do not express concrete realities that are self-evident by name alone. The recognition of a “link” between work and illnesses has always been a much more gradual, more problematic process than that linking work and accidents in the strict sense of the word.

In this article, we focus on the risks of becoming ill “on the occasion of or as a consequence of work”. In a review of a sample group of around 1,000 court sentences between 1936 and 1983, we analyse the influence of structural inertias, highlighting in particular the signs of change, in line with the evolution of legislation and the way it was interpreted by the courts. The changing social context is also taken into account.

El concepto de accidente de trabajo, y aún más el de enfermedad profesional, no designan realidades que se impongan invariablemente por su sola denominación. El reconocimiento de un "nexo" entre trabajo y enfermedades ha sido en todas partes mucho más tímido y dificultoso que el de los accidentes propiamente dichos.

Con el objetivo puesto en los riesgos de enfermar "con ocasión o por consecuencia del trabajo", una muestra de un millar de sentencias judiciales, repartidas entre 1936 y 1983, comprueba el peso de inercias estructurales y se detiene en los signos de inflexión, en función de la evolución de la legislación de referencia, pero también de sus interpretaciones por los tribunales y de su contexto.

Como expresión normalizada de hechos sociales (los riesgos del trabajo para la salud de quienes lo realizan), el "riesgo profesional" es un objeto en construcción, en un proceso más contradictorio que lineal.
Molecular docking analysis of mefluhybenamine with lung cancer targets
Authors: Alghamdi Youssef S.
Published: January 2023

Lung cancer is the most prevalent type of cancer worldwide, with 2.21 million cases and 1.80 million fatalities in 2020. The main factor influencing lung cancer is smoking, and the most common form of lung cancer, non-small cell lung cancer (NSCLC), accounts for around 80% of instances compared to small cell carcinoma, and about 75% of patients are already in an advanced stage when they are detected. Despite significant early detection and therapy improvements, the five-year survival rate for NSCLC is not encouraging. Therefore, it is essential to look into the molecular origins of non-small cell lung cancer to develop more effective therapeutic strategies—the binding affinities and energy landscape with the proteins. Cyclin Dependent kinase 2 (CDK2) and Insulin-like Growth Factor 1 Receptor (IGF1) were more substantial and sustained in lung cancer that was chosen as the two primary target proteins in this study. We screened the entire Drug Bank-prepared library of 1,55,888 compounds and found (2R,3R)-7-(Methylsulfonyl)-3-(2,4,5-trifluorophenyl)-1,2,3,4-tetrahydropyrido[1,2-a] benzimidazol-2-aminium (Mefluhybenamine) to be a significant inhibitor. Mefluhybenamine showed strong hydrogen bonding and other bonding topologies, such as van der Waals force, in its high docking scores of -6.168 Kcal/mol and -5.26 Kcal/mol, and ADMET results showed excellent bioavailability, remarkable solubility, no side effects, and toxicity. The molecular dynamic simulation confirmed the compound's stability and interaction pattern for 100 ns in an SPC water medium with the slightest deviation and fluctuation. Data shows that Mefluhybenamine is a potential candidate. However, validation of the compound is essential.
Immanuel Kant (trad. Alba Jiménez y Rogelio Rovira): Lecciones de metafísica según los apuntes de Volckmann
Authors: Straulino Torre Stefano
Published: January 2023

Reseña de:
Immanuel Kant (trad. Alba Jiménez y Rogelio Rovira): Lecciones de metafísica según los apuntes de Volckmann. Madrid, Siglo XXI, 2021, 294 pp. ISBN: 978-84-323-2035-4
The Self and the Categories. Remarks on Mario Caimis Kant's B Deduction
Authors: La Rocca Claudio
Published: January 2023

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La naturaleza analógica de las analogías de la experiencia en la Analítica de los principios
Authors: Turri Fernando
Published: January 2023

En el presente trabajo se examina la adecuación del uso del concepto de analogía para expresar la naturaleza general de los principios puros de la relación como analogías de la experiencia. Para este propósito no sólo se analiza la vinculación de la noción de analogía con las otras caracterizaciones de las analogías de la experiencia como principios dinámicos y regulativos, sino que también se rastrea la necesidad de su empleo en relación con el tipo de enlace categorial en el que se basan las analogías de la experiencia. Más precisamente, se pretende mostrar en qué sentido es necesario que Kant haga recurso del modelo filosófico de analogía por el que es determinado el carácter analógico de las analogías de la experiencia.
Intención, autolegislación, forma de la acción. Anscombe y Kant sobre los presupuestos de la moral
Authors: Placencia Luis
Published: January 2023

El presente trabajo busca contribuir a la reevaluación de la crítica que realizara G. E. M. Anscombe a la filosofía moral de Kant en su célebre e influyente artículo “Modern Moral Philosopy”, intentando poner a prueba una de las dos objeciones que la filósofa irlandesa realiza ahí, sc. la crítica a la idea de una concepción moral fundada en nociones como la de “deber” y “obligación moral”. Para ello este artículo intenta examinar – en virtud de la articulación que tiene esta crítica con otra posición de Anscombe (sc. la necesidad de suspender la “filosofía moral” hasta hallar una teoría adecuada de la acción) la conexión entre la concepción de la idea de “autolegislación” en Kant y su concepción de la acción
Call for Papers: VI Congreso Internacional SEKLE, Caminos kantianos del pensar.
Authors: Vázquez María Jesús
Published: January 2023

La Sociedad de Estudios Kantianos en Lengua Española (SEKLE) invita a participar en el Congreso Internacional que tendrá lugar en Santiago de Compostela del 15 al 19 de julio del 2024. El VI Congreso Internacional de la SEKLE celebra no solo el encuentro bienal de esta Sociedad de Estudios Kantianos sino también el tricentenario del nacimiento de Immanuel Kant (1724-1804). El lema Caminos del pensar, evoca metafóricamente tanto el Camino de Santiago y la bella ciudad anfitriona, como los múltiples caminos abiertos por el pensar kantiano a tres siglos de su nacimiento. Consideramos la historia evolutiva de su pensamiento, que, desde nuestro punto de vista, no recorre uno, sino varios caminos, lo que también vale para su historia efectual. Etimológicamente la palabra 'camino' o 'caminos' sugiere el problema del método o de los métodos del pensamiento de Kant y existe en nuestro pensador incluso “un camino que todavía no ha sido nunca hollado” (KrV, A 98), a saber, el de la Deducción trascendental de las categorías. Muchos son los caminos, tanto nacionales como internacionales, que pueden traer a las investigadoras y a los investigadores kantianos a Santiago de Compostela, en ocasión del tricentenario de su nacimiento. Además de los temas mencionados, son bienvenidas las contribuciones sobre cualquier otro aspecto del pensamiento de Kant. Los idiomas del congreso son: español, alemán, portugués, inglés, italiano, francés y gallego.
Abrikossoff’s skin tumor: Report of two cases
Authors:   Departement of Pathological Anatomy, CHU Hassan II Fez, Morocco, Gouzi Imane , Tahiri Layla , Abdellaoui Khaoula , Oujdi Sabrina , Douhi Zakia , Elloudi Sara , Baybay Hanane , Soughi Meryem , Mernissi Fatima Zahra , Fatemi Hinde , Chbani Laila , Hammas Nawal ,   Biomedical and Translational Research Laboratory, Faculty of Medicine and Pharmacy, Sidi Mohamed Ben Abdellah University, Fez, Morocco,   Department of Dermatology, CHU Hassan II Fez, Morocco.
Published: January 2023

Abrikossoff’s tumor, also known as granular cell tumor, is a rare tumor first described on the tongue by Ivanovich Abrikossoff in 1926. It is mainly located in the head and neck regions with preferential mucosal involvement and may occur at any age and in both sexes, although with a female predominance. Herein, we report two cases: the case of a nodule under the left breast in a 47-year-old female with a history of breast cancer and of a subcutaneous lesion on the right thigh in a 46-year-old female. The diagnosis of granular cell tumor was reached by biopsy with immunohistochemical staining, then treatment was completed by a large surgical excision. Key words: Abrikossoff; Skin; Granular cell tumor
DRESS syndrome with carbamazepine and Epstein–Barr virus reactivation
Authors:   Department of Dermatology, University Hospital Hassan II Fez, Morocco, Chhiti Sokaina , Douhi Zakia , Alaoui Imane Kacim , Elloudi Sara , Baybay Hanane , Mernissi Fatima Zahr
Published: January 2023

DRESS syndrome is a serious toxidermia, most often caused by anticonvulsants, including carbamazepine, which is responsible for a formidable clinical picture and which may be accompanied by viral reactivations, in particular of the herpes group. Herein, we report the case of a young girl affected by DRESS syndrome with the reactivation of EBV, in whom the evolution was favorable. Recurrent EBV infection is demonstrated by the presence of IgM antibodies to anti-EBV early antigen and IgG antibodies to anti-EBV nuclear antigen. Its pathogenesis suggests that viral reactivation is the consequence of a T-immune response directed against the causative drug in some patients. It is an unpredictable entity requiring immediate treatment, namely stopping the drug in question, monitoring the patient, searching for viral reactivation and notifying pharmacovigilance. Key words: Dress syndrom; carbamazepine; EBV; rash; reactivation
Eccrine poroma on the forearm in a child: A rare presentation
Authors:   Department of Dermatology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat. Morocco, El Gaitibi Fatima Azzahra ,   Department of Histopathology, Mohammed V University in Rabat, Ibn Sina University Hospital, Rabat. Morocco, Palamino Hind , Znati Kaoutar , Berbich Laila , Senouci Karima
Published: January 2023

Eccrine poroma (EP) is a benign adnexal tumor arising from the terminal duct of the sweat gland. It represents 10% of all sweat gland tumors and is most commonly found on the sole or the side of the foot [1]. Herein, we report a case of EP on the right forearm in a child. A thirteen-year-old female with no past medical history presented with an asymptomatic nodule on the right forearm (Fig. 1). The nodule had gradually increased in size and was not associated with pain, pruritus, or bleeding from the lesion. A physical examination revealed a firm, mobile flesh-colored nodule on the right forearm 7 × 6 mm in size. A dermoscopic examination revealed chalice-like vessels, whitish-pink areas, and yellow structureless areas (Fig. 2). The nodule was completely excised and histopathological findings showed a tumor proliferation connecting to the epidermis, organized on thick, cellular cords and composed of small, cohesive, round cells forming homogeneous layers. These cellular cords were separated by fibrous interstitial tissue, not especially inflammatory, and traversed by regularly distributed capillaries (Figs. 3 and 4). Based on these histological findings, a diagnosis of EP was reached.
Home Fare Advantage: An examination of the Role of Food and Beverages in Mercedes-Benz Stadium’s Event Experience
Authors: Slavich Mark A. , Rich Gregg , Williams Dylan
Published: January 2023

Through the lens of Expectation Disconfirmation Theory and with consideration of other event experience factors, our study examines how strategic concessions changes implemented by the Arthur M. Blank (AMB) Group with the building of Mercedes-Benz Stadium affect the fan experience at its professional sport events. These changes differ significantly from operational practices at most sport venues, with emphasis on eliminating bottlenecks to increase throughput and allowing for reduced costs without negatively affecting quality. Data were collected through an online survey of Atlanta United match attendees and an online observation. Results from this study suggest that management prioritization of concession services may be the most effective approach for engendering positive, overall event experiences from patrons.
The Smartness Mandate
Authors: Halpern Orit , Mitchell Robert
Published: January 2023

Over the last half century, "smartness"—the drive for ubiquitous computing—has become a mandate: a new mode of managing and governing politics, economics, and the environment.

Smart phones. Smart cars. Smart homes. Smart cities. The imperative to make our world ever smarter in the face of increasingly complex challenges raises several questions: What is this "smartness mandate"? How has it emerged, and what does it say about our evolving way of understanding—and managing—reality? How have we come to see the planet and its denizens first and foremost as data-collecting instruments?

In The Smartness Mandate, Orit Halpern and Robert Mitchell radically suggest that "smartness" is not primarily a technology, but rather an epistemology. Through this lens, they offer a critical exploration of the practices, technologies, and subjects that such an understanding relies upon—above all, artificial intelligence and machine learning. The authors approach these not simply as techniques for solving problems of calculations, but rather as modes of managing life (human and other) in terms of neo-Darwinian evolution, distributed intelligences, and "resilience," all of which have serious implications for society, politics, and the environment.

The smartness mandate constitutes a new form of planetary governance, and Halpern and Mitchell aim to map the logic of this seemingly inexorable and now naturalized demand to compute, illuminate the genealogy of how we arrived here, and point to alternative imaginaries of the possibilities and potentials of smart technologies and infrastructures.
Unconventional secretion of α-synuclein mediated by palmitoylated DNAJC5 oligomers
Authors: Wu Shenjie , Hernandez Villegas Nancy C , Sirkis Daniel W , Thomas-Wright Iona , Wade-Martins Richard , Schekman Randy
Published: January 2023

Alpha-synuclein (α-syn), a major component of Lewy bodies found in Parkinson’s disease (PD) patients, has been found exported outside of cells and may mediate its toxicity via cell-to-cell transmission. Here, we reconstituted soluble, monomeric α-syn secretion by the expression of DnaJ homolog subfamily C member 5 (DNAJC5) in HEK293T cells. DNAJC5 undergoes palmitoylation and anchors on the membrane. Palmitoylation is essential for DNAJC5-induced α-syn secretion, and the secretion is not limited by substrate size or unfolding. Cytosolic α-syn is actively translocated and sequestered in an endosomal membrane compartment in a DNAJC5-dependent manner. Reduction of α-syn secretion caused by a palmitoylation-deficient mutation in DNAJC5 can be reversed by a membrane-targeting peptide fusion-induced oligomerization of DNAJC5. The secretion of endogenous α-syn mediated by DNAJC5 is also found in a human neuroblastoma cell line, SH-SY5Y, differentiated into neurons in the presence of retinoic acid, and in human-induced pluripotent stem cell-derived midbrain dopamine neurons. We propose that DNAJC5 forms a palmitoylated oligomer to accommodate and export α-syn.
Persistent homology classification algorithm
Authors: De Lara Mark Lexter D.
Published: January 2023

Data classification is an important aspect of machine learning, as it is utilized to solve issues in a wide variety of contexts. There are numerous classifiers, but there is no single best-performing classifier for all types of data, as the no free lunch theorem implies. Topological data analysis is an emerging topic concerned with the shape of data. One of the key tools in this field for analyzing the shape or topological properties of a dataset is persistent homology, an algebraic topology-based method for estimating the topological features of a space of points that persists across several resolutions. This study proposes a supervised learning classification algorithm that makes use of persistent homology between training data classes in the form of persistence diagrams to predict the output category of new observations. Validation of the developed algorithm was performed on real-world and synthetic datasets. The performance of the proposed classification algorithm on these datasets was compared to that of the most widely used classifiers. Validation runs demonstrated that the proposed persistent homology classification algorithm performed at par if not better than the majority of classifiers considered.
The bony cap and its distinction from the distal phalanx in humans, cats, and horses
Authors: Smith Shannon , Yohe Laurel R. , Solounias Nikos
Published: January 2023

It has been recognized as early as the Victorian era that the apex of the distal phalanx has a distinct embryological development from the main shaft of the distal phalanx. Recent studies in regenerative medicine have placed an emphasis on the role of the apex of the distal phalanx in bone regrowth. Despite knowledge about the unique aspects of the distal phalanx, all phalanges are often treated as equivalent. Our morphological study reiterates and highlights the special anatomical and embryological properties of the apex of the distal phalanx, and names the apex “the bony cap” to distinguish it. We posit that the distal phalanx shaft is endochondral, while the bony cap is intramembranous and derived from the ectodermal wall. During development, the bony cap may be a separate structure that will fuse to the endochondral distal phalanx in the adult, as it ossifies well before the distal phalanges across taxa. Our study describes and revives the identity of the bony cap, and we identify it in three mammalian species: humans, cats, and horses (Homo sapiens, Felis catus domestica, and Equus caballus). During the embryonic period, we show the bony cap has a thimble-like shape that surrounds the proximal endochondral distal phalanx. The bony cap may thus play an inductive role in the differentiation of the corresponding nail, claw, or hoof (keratin structures) of the digit. When it is not present or develops erroneously, the corresponding keratin structures are affected, and regeneration is inhibited. By terming the bony cap, we hope to inspire more attention to its distinct identity and role in regeneration.
No detectable changes in reproductive behaviour of Caenorhabditis elegans males after 97 generations under obligatory outcrossing
Authors: Antoł Weronika , Byszko Jagoda , Dyba Alicja , Palka Joanna , Babik Wiesław , Prokop Zofia
Published: January 2023

In Caenorhabditis elegans, a species reproducing mostly via self-fertilization, numerous signatures of selfing syndrome are observed, including differences in reproductive behaviour compared to related obligatory outcrossing species. In this study we investigated the effect of nearly 100 generations of obligatory outcrossing on several characteristics of male reproductive behaviour. A genetically uniform ancestral population carrying a mutation changing the reproductive system to obligatory outcrossing was split into four independent populations. We predicted that the transition from the natural reproductive system, where males were extremely rare, to obligatory outcrossing, where males comprise 50% of the population and are necessary for reproduction, will increase the selection pressure on higher effectiveness of mating behaviour. Several characteristics of male mating behaviour during a 15 min interaction as well as copulation success were compared between the ancestral and evolved populations. No significant differences in male mating behaviour or fertilization success were detected between generations 1 and 97 of obligatory outcrossing populations. We found, however, that longer contact with females increased chances of successful copulation, although this effect did not differ between populations. We conclude that either selection acting on male mating behaviour has not been strong enough, or mutational input of new adaptive variants has not been sufficient to cause noticeable behavioural differences after 97 generations of evolution starting from genetically uniform population.
Um modelo de avaliação de executoras de projetos em assistência técnica e extensão rural
Authors: Cerveira Ricardo , Filho Vladimir Oganauskas , Ferraz Wecslei de Angeli , Cunha Christiano França da
Published: January 2023

A avaliação de projetos de assistência técnica e extensão rural sempre foi um problema a ser resolvido. Usando os aportes teóricos da eficiência e da satisfação, este artigo propôs um novo modelo para esta avaliação. Um estudo de caso (Projeto Bahia Produtiva) foi usado como objeto para fazer uma aplicação deste modelo. Este estudo de caso iniciou-se utilizando a Análise Envoltória de Dados (DEA, em inglês) para determinar a lista de empresas executoras de Assistência Técnica e Extensão Rural (ATER) em relação à sua eficiência. Após isso dados de satisfação dos stakeholders do projeto destas mesmas empresas, disponibilizadas pela entidade gestora do projeto, foram também usados. Como um novo modelo de avaliação proposto elaborou-se uma matriz conjunta com base nestes índices de satisfação e eficiência, assim obtendo-se quatro (04) tipologias das empresas quanto aos seus valores indicados. Observou-se que, com os resultados aqui expostos, esta nova proposta de avaliação permitirá aos gestores públicos uma análise mais assertiva e mais objetiva destas empresas executoras. Portanto notase que este artigo inova ao propor um modelo de avaliação das instituições executoras de Assistência Técnica e Extensão Rural e depois aplicá-lo para um projeto com o uso recursos públicos nacionais e também fontes internacionais.