bluuebunny/crossref_metadata_2025 huggingface dataset:
Linfoma intestinal em cão da raça Labrador: Relato de caso
Authors: Lopes Vitória , Lopes Vitória Viana , Sousa, Valesca Oliveira de , Paiva Mariana Gonçalves de Andrade , Gama Ana Paula Aragão
Published: October 2018

With the progress of veterinary medicine, a prolongation of animal life occurred and an occurrence of chronic diseases such as cancer. It is unanimous in the veterinary medical literature the importance of the complete evaluation of the patient for the resolution of the diagnosis, prognosis and therapy of the animals with neoplasias. Lymphoma is a neoplasm of malignant character and a rapid evolution of the history and the physical findings consist of the anatomical location and the affected organs. Clinical signs are usually non-specific. Anorexia / hyporexia, weight loss and transmission are common signs of various forms of lymphoma surgery. The definitive diagnosis is effected by the cytological and / or histopathological analysis of the affected tissues. The present study aimed to report a case of an 8-year-old Labrador Retriver dog that presented diarrhea with progressive weight loss, inappetence and vomiting. A hard consistency of approximately 3 cm was noticeable on palpation. Complementary exams such as radiography, abdominal ultrasonography and complete blood count were indicated. Confirming a presence of a neoplastic mass in the abdominal region, however, it was not known in which organ was located with suspicion that it would be present not spleen. The dog was referred for exploratory laparotomy surgery with possible splenectomy. It was observed that about 75 to 80% of the intestine was affected by neoplastic lesions. Several fragments were referred to a histopathology. The result of the histopathology concluded a malignant lymphosarcoma, presenting metastasis in the pancreas.
Análises microbiológicas de carne bovina moída comercializada em supermercados
Authors: Silva-Júnior Antonio Carlos , Freitas do Nascimento Jaqueline , Leôncio Tostes Ediluci do Socorro , Santos da Silva Anne do Socorro
Published: October 2018

Because the meat is a food rich in nutrients (fat, protein, minerals and vitamins, and easily accessible, ground beef is widely consumed throughout Brazil. However, during the production process it is a highly manipulated product that can lead to microbial contamination. In this way, the objective of this work was to analyze the microbiological characteristics of ground beef commercialized in supermarkets in the city of Macapá, Amapá. Three samples of ground beef were taken in portions of 500 g randomly direct from the refrigerated counters in ten supermarkets located in different points of the city of Macapá during from February to July of 2018, totaling 30 samples. At the time of the collection, the infrared thermometer was used to measure the exposure temperature. The samples were sent to the Food Science and Technology Center of the Institute of Scientific and Technological Research of the State of Amapá-IEPA. The microbiological analyzes were the presence / absence of Salmonella spp. in 25 g of sample and Standard Coagulase-positive Staphylococcus Count (CFU / g). Regarding the temperature of exposure, it was possible to verify that 8 (88.89%) of the samples evaluated had temperatures above 4 ° C, not complying with current legislation. The microbiological analyzes performed in this study showed absence in all samples for Salmonella spp., but positive results in 100% of the establishments evaluated for Staphylococcus coagulase positive, where the amplitude was 2.3x103 at 2x105 CFU/g. Supermarkets even using mechanized processes during the production stages and passing through a standard of control considered more demanding than other establishments, it was still possible to contact an expressive number of Staphylococcus contamination, that even if the legislation does not provide this microorganism, it is still considered one of the pathogens most involved with outbreaks and sporadic cases of food poisoning.
KAYIN KAPLAMALARIN YÜZEY PÜRÜZLÜLÜĞÜ ÜZERİNE YAŞLANDIRMANIN ETKİSİ
Authors: ÖZDEMİR Ferhat , DALGIÇ Eda , ÖZĞAN Ali Osman , AVŞAR Eda
Published: October 2018

Bu
çalışmada, kayın odunu kaplamaları üzerinde yaşlandırma işlemi uygulanarak,
yaşlandırmanın yüzey pürüzlülüğü üzerine etkileri araştırılmıştır. Kayın
kaplamalardan hazırlanan numuneler öncelikle iklimlendirme kabininde klimatize
edildikten sonra yaşlandırma işlemine maruz bırakılmıştır. Yaşlandırma işlemi
uygulanan numunelerin yüzey pürüzlülük değerleri ISO 4287 standartlarına göre
Marsurf M300 cihazı ile ölçülmüştür. Test örneklerinin Ra, Rz ve Rmax değerleri
belirlenmiştir. Elde edilen verilere göre yaşlandırma işlem süresinin artması
ile yüzey pürüzlülük değerlerinin arttığı belirlenmiştir.
SHARP DISTILLATION FOR QUATERNARY SYSTEMS
Authors: Frolkova A. V. , Peshekhontseva M. S. , Gaganov I. S.
Published: October 2018

Conditions of sharp distillation were considered for zeotropic quaternary system (two pairs of components are characterized by relative volatility close to 1) and systems with one (with minimum or maximum boiling point) and two (with minimum and maximum boiling point) binary azeotropes. Regions of compositions for which sharp distillation is effective (distillate and bottom flows don't contain common components) were determined on the basis of analyzing diagrams of unit manifolds of distribution coefficients (distribution coefficients of two components are higher than one, and those of another two components - lower than one). This kind of separation can be recommended if it doesn’t cause an increase in the number of apparatuses in the separation flowsheet. If the system contains azeotropes of saddle type that can generate separatric manifolds, the possibility and expedience of sharp separation decreases. The conclusions were confirmed by simulation of the distillation process in AspenPlus V.10.0 for real and industrially important quaternary systems: ethyl acetate - benzene - toluene - butyl acetate; acetone - methanol - ethanol - propanol-2; methyl acetate - methanol - acetic acid - acetic anhydride and cyclohexene - cyclohexane - cyclohexanone - phenol. Mathematical modeling was carried out using local compositions models Wilson and NRTL-HOC. The relative error of vapor-liquid equilibrium description is less than 4%. The vapor-liquid equilibrium was simulated, a phase diagram was constructed and analyzed, the parameters of sharp distillation column operation (the number of stages, the feed-stage and reflux ratio) were determined for all systems. The effectiveness of using sharp distillation for the system with phenol was confirmed for a wide range of compositions.
SYNTHESIS OF FLOWSHEETS FOR SEPARATION OF MULTIPHASE MIXTURES: STATE OF THE ART
Authors: Frolkova A. V. , Merkulyeva A. D. , Gaganov I. S.
Published: October 2018

The paper presents an analysis of the current state of research on separation flowsheets based on the combination of distillation and phase separation processes, as well as heteroazeotropic distillation. It is shown that the works of foreign researchers devoted to the study of flowhseets with decanters are more focused on finding ways to reduce energy consumption by introducing additional separators, a combination of several methods (extractive and heteroazeotropic complex columns with external decanters. The task of synthesizing all possible separation flowsheets is not considered in these works. In this paper, a complete set of flowsheets of different structures based on the combination of distillation and phase separation processes, including the use of columns with an external decanter, is proposed for water - butyl acetate - methanol and methanol - heptane-water ternary mixtures separation. Aspen Plus and NRTL model were used for mathematical modelling of phase equilibrium (the relative error of describing liquid-vapor and liquid-liquid equilibrium is less than 5%) was chosen as a method of research. Operating parameters for distillation columns (the number of theoretical plates, feed plate, reflux ratio) and the total energy consumption were obtained for each case. The necessity of using a double feed-plate column for separating of propanol-1 - water - butanol-1 and ethyl acetate - water - butyl acetate ternary systems was explained by the presence of extractive effect. Analytical review of modern publications and results of own research allowed to formulate a number of recommendations for the synthesis of energy effective flowsheets based on a combination of distillation and phase separation processes.
Development of system for detecting hidden objects based on UWB pulse radar
Authors: Tran Thang Dai , Do Tuan Hong , Hoang Ha Manh
Published: October 2018

This paper present a solution for detecting hidden objects based on UWB pulse radar. In this paper, we introduce an overview of UWB systems, the theory related and used in the process to implement the project. We present the steps to collect and process data through object identification algorithm, improve algorithm for detecting hidden objects in some kind of environments. We evaluate the obtained results, conclude for applying orientation and development of the subject.
DSP-based pulse width modulation generator for very Spare Matrix Converter
Authors: Nguyen Anh Gia Hoang , Nguyen Tuyen Dinh , Lee Hong Hee
Published: October 2018

This paper present a modulation scheme for the Spare Matrix Converter (SMC) topology. The proposed method uses the space vector modulation (SVPWM) technique to control the converter’s rectifier stage and inverter stage. This method achieved the maximum modulation ratio of 0.866 with sinusoidal input/output current waveforms. In the other hand, a simple real-time implementation method avoiding additional CPLD or FPGA devices is introduced. This technique is verified through simulation results using PSIM software and experimental results a 32-bit floating-point DSP (TMS 320F28335).
Seamless transfer with interactive compensation algorithm for three-phase grid-connected inverter
Authors: Tran Vu Thanh , Nguyen Tuyen Dinh , Phan Dzung Quoc
Published: October 2018

This paper proposes an interactive control algorithm for seamless transfer of three-phase grid-connected converter between grid-tide mode and stand-alone mode. In order to archive a smooth transfer between two modes, the voltage controller and current controller are designed to generate the output voltage reference of PWM with no interrupted transition during islanding operation and grid connected operation. Additionally, a suitable phaselocked loop (PLL) algorithm is posed to obtain the phase angle of grid voltage continuously during operation time even if the utility outages. With the proposed algorithm, the control algorithm guarantees a smooth profile voltage across the local load when the grid is being disconnected or reconnected. In this paper, the simulation and experiment results verify the proposed method.
A sliding mode algorithm for antilock braking/traction control of EVs
Authors: Vu Minh Ngoc , Ta Minh Cao
Published: October 2018

This paper presents a slip suppression controller using sliding mode control method for electric vehicles which aims to improve the control performance of Evs in both driving and braking mode. In this method, a sliding mode controller is designed to obtain the maximum driving force by suppressing the slip ratio. The numerical simulations for one wheel model under variations in mass of vehicle and road condition are performed and demonstrated to show the effectiveness of the proposed method.
Analisis Persepsi Pengunjung untuk Pengembangan Hutan Kota Metro sebagai Objek Wisata Alam
Authors: Sari Hepy Purnama , Setiawan Agus , Winarno Gunardi Djoko , Harianto Sugeng Prayitno
Published: October 2018

Persepsi pengunjung dalam pengembangan fasilitas, pelayanan, akomodasi dan infrastruktur penting diketahui sebagai langkah awal dalam pengembangan hutan kota sebagai objek wisata alam. Penelitian ini bertujuan untuk mengetahui bagaimana persepsi pengunjung terhadap pengembangan hutan kota yang berada di Kota Metro. Penelitian ini menggunakan metode deskriptif kualitatif. Data primer didapatkan melalui observasi dan wawancara menggunakan kuesioner, kemudian dianalisis menggunakan Skala Likert.  Hasil penelitian menunjukkan bahwa persepsi pengunjung menyatakan perlu adanya pengembangan pada fungsi sosial hutan kota, pengembangan tersebut dapat dilakukan dengan penataan ruang untuk vegetasi, fasilitas wisata dan lahan parkir. Penataan ruang tersebut diharapkan dapat menjadikan Hutan Kota Metro sebagai  tempat interaksi sosial yang juga dapat berfungsi sebagai objek wisata alam.
PENGARUH ADAPTASI LINGKUNGAN USAHA DAN KEUNGGULAN SUMBER DAYA MANUSIA (SDM) TERHADAP KEUNGGULAN BERSAING MELALUI KUALITAS PRODUK ANYAMAN PANDAN DI JOMBANG
Authors: Wahyuningsih Roy
Published: October 2018

Tujuan dalam penelitian ini adalah untuk menganalisis (1) pengaruh positif Adaptasi Lingkungan usaha terhadap Kualitas produk, (2) pengaruh positif keunngulan SDM terhadap kualitas produk, (3) pengaruh positif kualitas produk terhadap keunggulan bersaing, (4) pengaruh positif adaptasi lingkungan usaha terhadap keunggulan bersaing, (5) pengaruh positif keunggulan SDM terhadap keunggulan bersaing.Penelitian ini menggunakan metode kuantitatif. Populasi dalam penelitian ini adalah seluruh perajin anyaman pandan yang berada di Jombang yaitu sebesar 1634 perajin anyaman pandan dengan sampel sebesar 128 responden. Teknik pengambilan sampel yang digunakan dengan cara Proporsional Random Sampling. Kuesioner dan tes digunakan dalam teknik pengumpulan data pada penelitian ini. Peneliti menggunakan Structural Equation Modelling (SEM) sebagai alat untuk menganalisis data.Hasil penelitian menunjukkan bahwa  (1) Adaptasi Lingkungan usaha secara positif berpengaruh terhadap Kualitas produk, (2) keunggulan SDM  secara positif berpengaruh terhadap kualitas produk, (3) kualitas produk  secara positif berpengaruh terhadap keunggulan bersaing, (4) adaptasi lingkungan usaha  secara positif berpengaruh terhadap keunggulan bersaing, (5) keunggulan SDM  secara positif berpengaruh terhadap keunggulan bersaing.Saran dari penelitian ini yaitu (1) para perajin anyaman pandan seyogyanya memusatkan perhatian untuk meningkatkan  sumber daya manusia (SDM) misalnya dengan jalan memperbanyak mengikuti pelatihan-pelatihan, (2) para perajin anyaman pandan di Jombang senantiasa meningkatkan ketrampilan-ketrampilan, (3) Sedangkan untuk meningkatkan keunggulan bersaing, para perajin anyaman pandan di Jombang sebaiknya Menjaga kualitas produk, Menumbuhkan sikap soliditas antara pelanggan, pembeli, pemasok dan para perajin anyaman.
Hubungan Kecemasan Dengan Cardiac Output Pada Pasien Pre Operasi Sectio Caesarea Di Instalasi Kamar Operasi Rumah Sakit Umum Islam Orpeha Tulungagung
Authors: Murniati Anis
Published: October 2018

The nature of a woman is childbirth, all women at the time of labor need to have a good labour  and give birth to a healthy and perfect baby. Childbirth can be normal, but also many in the process of labor that experienced obstacles so that it is done with the procedure of surgery sectio caesaria (SC). Childbirth with  surgery for some mothers is a scary thing so that not a few mothers who experience anxiety before SC is done. Anxiety is a feeling that is not clear and worried because there is something that threatens one's security. Anxiety in each person is certainly not the same, this anxiety can lead to various changes in the body's system can even interfere with heart function and result in changes in cardiac output. Changes in cardiac output may result in changes in the patient's blood pressure that may affect the success of SC. This research use correlational research design with csoss sectional approach. The location of research is premedication room of operation room of ORPEHA Islamic Hospital Tulungagung with the number of 32 respondents. The results showed the mean cardiac output value of 7625.62. The results of statistical data analysis with Pearson correlation test obtained 0,000 significance results so Ho is rejected which means there is an association between anxiety with cardiac output in patients with SC surgery with large correlation pearson 1, which means the strength of the relationship is very strong. This happens because anxiety can affect the production of catecholamines and cortisol, where this hormone can stimulate the occurrence of vasodilation of blood vessels resulting in blood flowing rapidly and much so that oxygen is distributed more, thus in people who are anxious will an increase in cardiac output. The conclusion of this study is that there is an association between anxiety with cardiac output in patients with preoperative sectio caesarea at the operating room installation of Islamic Orpeha tulungagung public hospital with the strength of the relationship of 1.
PRINCIPALES MODIFICACIONES INTRODUCIDAS AL PROCESO DE SUCESIÓN POR EL CÓDIGO GENERAL DEL PROCESO
Authors: Giraldo Castaño Jesael Antonio
Published: October 2018

PRINCIPALES MODIFICACIONES INTRODUCIDAS AL PROCESO DE SUCESIÓN POR EL CÓDIGO GENERAL DEL PROCESO
LA PRUEBA PERICIAL EN ANÁLISIS DE LAS CONSECUENCIAS GENERADAS POR LA ELIMINACIÓN DE LA POSIBILIDAD DE OBJETAR EL DICTAMEN PERICIAL
Authors: Acuña Gamba Eduardo José
Published: October 2018

LA PRUEBA PERICIAL EN ANÁLISIS DE LAS CONSECUENCIAS GENERADAS POR LA ELIMINACIÓN DE LA POSIBILIDAD DE OBJETAR EL DICTAMEN PERICIAL
Synthesis and Recovery of Pyridine- and Piperidine-based Camphorsulfonamide Organocatalysts Used for Michael Addition Reaction
Authors: Kisszékelyi Péter , Nagy Sándor , Tóth Blanka , Zeller Bálint , Hegedűs László , Mátravölgyi Béla , Grün Alajos , Németh Tamás , Huszthy Péter , Kupai József
Published: October 2018

Two new pyridine-based asymmetric bifunctional organocatalysts containing one or two camphorsulfonamide units were synthesized. Asymmetric Michael addition of pentane-2,4-dione to β-nitrostyrene was catalyzed by these organocatalysts. During our experiments, influence of the solvent and temperature on the yield and enantioselectivity was studied. Using monocamphorsulfonamide derivative the S enantiomer of the corresponding Michael adduct was gained with moderate yield (up to 51 %) and low enantiomeric excess (up to 18 %). Organic solvent nanofiltration was successfully applied for the recovery of these organocatalysts. Furthermore, pyridine camphorsulfonamide was reduced to its piperidine derivative. Using piperidine monosulfonamide derivative racemic Michael adduct was obtained with excellent yield (up to 89 %). Beside its organocatalytic relevance, piperidine monosulfonamide derivative may also possess biological activity.
Force-Amplified Soft Electromagnetic Actuators
Authors: Doerger Stanley R. , Harnett Cindy K.
Published: October 2018

Electrically-driven direct current (DC) motors are the core component of conventional robots thanks to the ease of computer control and high torque for their size. However, DC motors are often manually attached and soldered into robotic assemblies, and they are not flexible. For soft robotics, researchers have looked to new, compliant materials that are compatible with 3-D printing or other automated assembly methods. In this work we use a computer-controlled embroidery machine to create flat motor windings in flexible fabrics. We model their electromagnetic fields and present them as linear actuators that move a permanent magnet attached to a cable. The fabrication method puts some constraints on the coil design, which are discussed. However, the planar nature of the embroidered sheets enables the designer to use laminar fabrication methods, such as stacking or layering into parts, during 3-D printing. The soft motor windings produced static holding forces of up to 0.25 N and could lift a 0.3 g mass several cm using direct drive. A 3-D printed mechanical amplifier with two stages was able to quadruple the lifting mass, reducing the travel by a factor of 4. Machine embroidery-installed cables and motor coils could lead to “bolts and nuts free” fabrication of thin, electrically-driven cable actuators.
Effect of Duration of Dietary Rapeseed and Soybean Oil Feeding on Physical Characteristics, Fatty Acid Profile, and Oxidative Stability of Pig Backfat
Authors: Okrouhlá Monika , Stupka Roman , Čítek Jaroslav , Lebedová Nicole , Zadinová Kateřina
Published: October 2018

This study compared the effect of two vegetable oils and their feeding duration on pig backfat quality. The experiment was conducted with 60 DanBred pigs that were fed a diet supplemented (40 g/kg) with rapeseed or soybean oil for 2, 4 or 6 weeks before slaughter at 152 d of age. The supplementation of both vegetable oils in the diets for 6 weeks negatively changed backfat consistency. The pigs fed soybean oil for 4 (17.64%) and 6 weeks (18.52%) before slaughter showed an increase in backfat linoleic acid content (p = 0.002), whereas, in contrast to the other groups, rapeseed oil in the diet for 6 weeks (2.38%) increased α-linolenic acid content (p = 0.039). The content of PUFAs (p = 0.024) and n-6 PUFAs (p = 0.003) was increased by adding soybean oil to the diet for 4 and 6 weeks. The ratio of n-6/n-3 PUFAs was decreased (p = 0.040) by supplementing rapeseed oil for 4 and 6 weeks. The oil feeding duration decreased (p < 0.001) the atherogenic and thrombogenic indices. The lipid oxidative stability of backfat stored for 3 and 5 days increased (p < 0.001) in pigs fed dietary vegetable oils for 6 weeks prior to slaughter. In conclusion, the feeding of rapeseed oil for 4 weeks before slaughter is sufficient for improving the FA profile without negative effect on the consistency of the backfat.
Determining the Rate-Limiting Step for Light-Responsive Redox Regulation in Chloroplasts
Authors: Yoshida Keisuke , Hisabori Toru
Published: October 2018

Thiol-based redox regulation ensures light-responsive control of chloroplast functions. Light-derived signal is transferred in the form of reducing power from the photosynthetic electron transport chain to several redox-sensitive target proteins. Two types of protein, ferredoxin-thioredoxin reductase (FTR) and thioredoxin (Trx), are well recognized as the mediators of reducing power. However, it remains unclear which step in a series of redox-relay reactions is the critical bottleneck for determining the rate of target protein reduction. To address this, the redox behaviors of FTR, Trx, and target proteins were extensively characterized in vitro and in vivo. The FTR/Trx redox cascade was reconstituted in vitro using recombinant proteins from Arabidopsis. On the basis of this assay, we found that the FTR catalytic subunit and f-type Trx are rapidly reduced after the drive of reducing power transfer, irrespective of the presence or absence of their downstream target proteins. By contrast, three target proteins, fructose 1,6-bisphosphatase (FBPase), sedoheptulose 1,7-bisphosphatase (SBPase), and Rubisco activase (RCA) showed different reduction patterns; in particular, SBPase was reduced at a low rate. The in vivo study using Arabidopsis plants showed that the Trx family is commonly and rapidly reduced upon high light irradiation, whereas FBPase, SBPase, and RCA are differentially and slowly reduced. Both of these biochemical and physiological findings suggest that reducing power transfer from Trx to its target proteins is a rate-limiting step for chloroplast redox regulation, conferring distinct light-responsive redox behaviors on each of the targets.
Innovation as Conservation: Reflexivity, National Cinema, and Male Hegemony in Takeshi Kitano’s Hana-bi
Authors: Karatsu Rie
Published: October 2018

The article aims to illuminate the intersections of reflexivity, national cinema, and male hegemony in Takeshi Kitano’s award-winning film Hana-bi (1997). Hana-bi marks a transition to a discourse espousing Japaneseness, particularly the dominant male versions of national identity in Kitano’s filmmaking. The article assesses the impact of reflexivity that plays a crucial role in the discourse. To demonstrate these ideas, this article is separated into two sections. The first section discusses the problematic concepts of national cinema, analyzes the cultural and industrial contexts that informed Hana-bi, and illustrates the way in which the film reinforces the Japanese national essence and gender norms. The second section highlights the functions of reflexivity used in the film, drawing from the critical concept developed by film and television scholar Jane Feuer (1982).
Trends in SPR Cytometry: Advances in Label-Free Detection of Cell Parameters
Authors: Schasfoort Richard B. M. , Abali Fikri , Stojanovic Ivan , Vidarsson Gestur , Terstappen Leon W. M. M.
Published: October 2018

SPR cytometry entails the measurement of parameters from intact cells using the surface plasmon resonance (SPR) phenomenon. Specific real-time and label-free binding of living cells to sensor surfaces has been made possible through the availability of SPR imaging (SPRi) instruments and researchers have started to explore its potential in the last decade. Here we will discuss the mechanisms of detection and additionally describe the problems and issues of mammalian cells in SPR biosensing, both from our own experience and with information from the literature. Finally, we build on the knowledge and applications that has already materialized in this field to give a forecast of some exciting applications for SPRi cytometry.
POFUT1 as a Promising Novel Biomarker of Colorectal Cancer
Authors: Chabanais Julien , Labrousse François , Chaunavel Alain , Germot Agnès , Maftah Abderrahman
Published: October 2018

Background: While protein O-fucosyltransferase 1 (POFUT1) overexpression has been recently proposed as a potential biomarker for different cancer types, no study was carried out on POFUT1 implication in colorectal cancer (CRC). Methods: Data from 626 tumors and 51 non-tumor adjacent tissues available in FireBrowse had been used in this study. Statistical analyses on POFUT1 expression and gene copy number, NOTCH receptors (main targets of POFUT1 enzymatic activity) expression and association of POFUT1 and NOTCH1 expressions with clinical parameters were investigated. Data were completed by POFUT1 histological labeling on six tumor tissues from patients with CRC. Results: We found that POFUT1 is overexpressed from the stage I (p < 0.001) and 76.02% of tumors have a 20q11.21 amplification, associated in 90.13% of cases with a POFUT1 overexpression, compared to non-tumor adjacent tissues. The POFUT1 copy number in tumors is mainly between 2 and 3. POFUT1 is positively correlated with NOTCH1 (rs = 0.34, p < 0.001), NOTCH3 (rs = 0.087, p = 0.0297), and NOTCH4 (rs = 0.097, p = 0.0148) expressions, while negatively correlated with NOTCH2 expression (rs = −0.098, p = 0.0142). POFUT1 overexpression is markedly associated with rectal location, non-mucinous adenocarcinoma and cancer stages IV and M1. NOTCH1 overexpression is only associated with rectal location and non-mucinous adenocarcinoma. Conclusion: We conclude that POFUT1 is overexpressed in CRC from stage I, and its high expression is associated with metastatic process, probably through NOTCH pathway activation. Then, POFUT1 could represent a potential novel biomarker for CRC diagnosis.
Scanning Electron Microscopy of Circulating Tumor Cells and Tumor-Derived Extracellular Vesicles
Authors: Nanou Afroditi , Crespo Mateus , Flohr Penny , De Bono Johann S. , Terstappen Leon W. M. M.
Published: October 2018

To explore morphological features of circulating tumor cells (CTCs) and tumor-derived extracellular vesicles (tdEVs), we developed a protocol for scanning electron microscopy (SEM) of CTCs and tdEVs. CTCs and tdEVs were isolated by immunomagnetic enrichment based on their Epithelial Cell Adhesion Molecule (EpCAM) expression or by physical separation through 5 μm microsieves from 7.5 mL of blood from Castration-Resistant Prostate Cancer (CRPC) patients. Protocols were optimized using blood samples of healthy donors spiked with PC3 and LNCaP cell lines. CTCs and tdEVs were identified among the enriched cells by fluorescence microscopy. The positions of DNA+, CK+, CD45− CTCs and DNA−, CK+, CD45− tdEVs on the CellSearch cartridges and microsieves were recorded. After gradual dehydration and chemical drying, the regions of interest were imaged by SEM. CellSearch CTCs retained their morphology revealing various shapes, some of which were clearly associated with CTCs undergoing apoptosis. The ferrofluid was clearly distinguishable, shielding major portions of all isolated objects. CTCs and leukocytes on microsieves were clearly visible, but revealed physical damage attributed to the physical forces that cells exhibit while entering one or multiple pores. tdEVs could not be identified on the microsieves as they passed through the pores. Insights on the underlying mechanism of each isolation technique could be obtained. Complete detailed morphological characteristics of CTCs are, however, masked by both techniques.
Demonstration of the Use of 3D X-ray Tomography to Compare the Uniformity of Catalyst Coatings in Open-Cell Foams
Authors: Zanota Marie-Line , Pallier Stéphanie , Dousse Anaïs , Lachambre Joël , Meille Valérie
Published: October 2018

Coating open-cell foams by a catalytic layer is a necessary step to obtain structured catalytic foam reactors. The dip-coating method, consisting of immersing the foam in a suspension or in a sol-gel, is generally used to obtain the coating. The excess of liquid has to be evacuated from the foam to obtain a thin layer. Different methods to remove this excess of liquid have been investigated in the present work. The objective was to show that 3D X-ray tomography coupled to image analysis could be a tool to discriminate the methods by analysing the spatial localisation of the catalyst layer throughout the whole foam samples. A simple blowing by air in every direction seems to not be appropriate to obtain uniform coatings.
Non-Local Buckling Analysis of Functionally Graded Nanoporous Metal Foam Nanoplates
Authors: Wang Yanqing , Zhang Zhiyuan
Published: October 2018

In this study, the buckling of functionally graded (FG) nanoporous metal foam nanoplates is investigated by combining the refined plate theory with the non-local elasticity theory. The refined plate theory takes into account transverse shear strains which vary quadratically through the thickness without considering the shear correction factor. Based on Eringen’s non-local differential constitutive relations, the equations of motion are derived from Hamilton’s principle. The analytical solutions for the buckling of FG nanoporous metal foam nanoplates are obtained via Navier’s method. Moreover, the effects of porosity distributions, porosity coefficient, small scale parameter, axial compression ratio, mode number, aspect ratio and length-to-thickness ratio on the buckling loads are discussed. In order to verify the validity of present analysis, the analytical results have been compared with other previous studies.
Localization Parameters for Two Interacting Particles in Disordered Two-Dimensional Finite Lattices
Authors: Chattaraj Tirthaprasad
Published: October 2018

I study spreading of two interacting hardcore bosons in disordered two-dimensional finite lattices from an initial occupation of two adjacent sites. The parameters related to the spreading of the particles provide an insight on the effect of interaction. I find that the presence of interaction makes the particles less localized than the non-interacting ones within the range of disorder strength W ≤ 4 and interaction strength V ≤ 4 . If the interaction strength is higher, then particles localize more. A transition with changes in the character of dominant correlations is found at critical disorder strengths for each chosen strength of interaction. The nature of correlations between the particles as nearest neighbours becomes dominant beyond these disorder strengths.
Nanoemulsions as a Form of Perfumery Products
Authors: Sikora Elzbieta , Małgorzata Miastkowska , Wolinska Kennard Katarzyna , Lason Elwira
Published: October 2018

Alcohol-based perfumes, e.g., eau de parfum, eau de toilette, eau de cologne or au fraiche, are the most common type of fragrance products available on the market. There are also alcohol-free fragrance products, mainly in the form of solid or oil perfume. From the consumers’ point of view, such perfumery products are of interest; therefore, looking for new solutions is still interesting. Nanoemulsions are liquid, kinetically stable colloidal dispersions, consisting of an aqueous phase, an oil phase and a surfactant, with or without a co-surfactant. They are transparent, not greasy, easy to spray and spread. Additionally, they show capacity to protect fragrances from oxidation. The development of a water-based perfumes in the form of stable nanoemulsions containing fragrance compositions (in the range of 5–15%), stabilized by nonionic surfactants, allows to create safe products for a wider group of consumers, including children, adolescents and people with sensitive skin. In this article, an application of nanoemulsions as a potential form of perfumery products were described.
Structural and Magnetic Properties of Co‒Mn Codoped ZnO Nanoparticles Obtained by Microwave Solvothermal Synthesis
Authors: Wojnarowicz Jacek , Omelchenko Myroslava , Szczytko Jacek , Chudoba Tadeusz , Gierlotka Stanisław , Majhofer Andrzej , Twardowski Andrzej , Lojkowski Witold
Published: October 2018

Zinc oxide nanoparticles codoped with Co2+ and Mn2+ ions (Zn(1−x−y)MnxCoyO NPs) were obtained for the first time by microwave solvothermal synthesis. The nominal content of Co2+ and Mn2+ in Zn(1−x−y)MnxCoyO NPs was x = y = 0, 1, 5, 10 and 15 mol % (the amount of both ions was equal). The precursors were obtained by dissolving zinc acetate dihydrate, manganese (II) acetate tetrahydrate and cobalt (II) acetate tetrahydrate in ethylene glycol. The morphology, phase purity, lattice parameters, dopants content, skeleton density, specific surface area, average particle size, average crystallite size, crystallite size distribution and magnetic properties of NPs were determined. The real content of dopants was up to 25.0% for Mn2+ and 80.5% for Co2+ of the nominal content. The colour of the samples changed from white to dark olive green in line with the increasing doping level. Uniform spherical NPs with wurtzite structure were obtained. The average size of NPs decreased from 29 nm to 21 nm in line with the increase in the dopant content. Brillouin type paramagnetism and an antiferromagnetic interaction between the magnetic ions was found for all samples, except for that with 15 mol % doping level, where a small ferromagnetic contribution was found. A review of the preparation methods of Co2+ and Mn2+ codoped ZnO is presented.
Dynamics of the US Housing Market: A Quantal Response Statistical Equilibrium Approach
Authors: Ömer Özlem
Published: October 2018

In this article, we demonstrate that a quantal response statistical equilibrium approach to the US housing market with the help of the maximum entropy method of modeling is a powerful way of revealing different characteristics of the housing market behavior before, during and after the recent housing market crash in the US. In this line, a maximum entropy approach to quantal response statistical equilibrium model (QRSE) is employed in order to model housing market dynamics in different phases of the most recent housing market cycle using the S&P Case Shiller housing price index for 20 largest- Metropolitan Regions, and Freddie Mac housing price index (FMHPI) for 367 Metropolitan Cities for the US between 2000 and 2015. Estimated model parameters provide an alternative way to understand and explain the behaviors of economic agents, and market dynamics by questioning the traditional economic theory, which takes assumption for the behavior of rational utility maximizing representative agent with self-fulfilled expectations as given.
Cities, from Information to Interaction
Authors: Netto Vinicius M. , Brigatti Edgardo , Meirelles João , Ribeiro Fabiano L. , Pace Bruno , Cacholas Caio , Sanches Patricia
Published: October 2018

From physics to the social sciences, information is now seen as a fundamental component of reality. However, a form of information seems still underestimated, perhaps precisely because it is so pervasive that we take it for granted: the information encoded in the very environment we live in. We still do not fully understand how information takes the form of cities, and how our minds deal with it in order to learn about the world, make daily decisions, and take part in the complex system of interactions we create as we live together. This paper addresses three related problems that need to be solved if we are to understand the role of environmental information: (1) the physical problem: how can we preserve information in the built environment? (2) The semantic problem: how do we make environmental information meaningful? and (3) the pragmatic problem: how do we use environmental information in our daily lives? Attempting to devise a solution to these problems, we introduce a three-layered model of information in cities, namely environmental information in physical space, environmental information in semantic space, and the information enacted by interacting agents. We propose forms of estimating entropy in these different layers, and apply these measures to emblematic urban cases and simulated scenarios. Our results suggest that ordered spatial structures and diverse land use patterns encode information, and that aspects of physical and semantic information affect coordination in interaction systems.
Probabilities and Epistemic Operations in the Logics of Quantum Computation
Authors: Dalla Chiara Maria Luisa , Freytes Hector , Giuntini Roberto , Leporini Roberto , Sergioli Giuseppe
Published: October 2018

Quantum computation theory has inspired new forms of quantum logic, called quantum computational logics, where formulas are supposed to denote pieces of quantum information, while logical connectives are interpreted as special examples of quantum logical gates. The most natural semantics for these logics is a form of holistic semantics, where meanings behave in a contextual way. In this framework, the concept of quantum probability can assume different forms. We distinguish an absolute concept of probability, based on the idea of quantum truth, from a relative concept of probability (a form of transition-probability, connected with the notion of fidelity between quantum states). Quantum information has brought about some intriguing epistemic situations. A typical example is represented by teleportation-experiments. In some previous works we have studied a quantum version of the epistemic operations “to know”, “to believe”, “to understand”. In this article, we investigate another epistemic operation (which is informally used in a number of interesting quantum situations): the operation “being probabilistically informed”.
From High School Access to Postsecondary Success: An Exploratory Study of the Impact of High-Rigor Coursework
Authors: Morgan T. , Zakhem Diana , Cooper Wendy
Published: October 2018

Educators and policymakers are keenly aware of the need to prepare students to compete in an increasingly global society. It is widely accepted that a high school diploma is not sufficient and that secondary schools have a responsibility to prepare students to be college and career ready. This study examined participation in a rigorous secondary curriculum and the corresponding outcomes related to college enrollment, persistence, and graduation. Focusing on the involvement of students in high-rigor courses that provide a stronger pathway to college, we seek to understand further the indicators that lead to postsecondary success. The sample comprises 1464 students who graduated from high school between 2009 and 2014. The primary analytic technique was binary logistic regression. The results from this study confirmed that a positive relationship exists between high-rigor courses and college success. This relationship was evident even after controlling for relevant student demographics including gender, ethnicity, and socioeconomic status. The academic benefits of the high-rigor course participation are discussed.
Parallel K-Means Clustering for Brain Cancer Detection Using Hyperspectral Images
Authors: Torti Emanuele , Florimbi Giordana , Castelli Francesca , Ortega Samuel , Fabelo Himar , Callicó Gustavo Marrero , Marrero-Martin Margarita , Leporati Francesco
Published: October 2018

The precise delineation of brain cancer is a crucial task during surgery. There are several techniques employed during surgical procedures to guide neurosurgeons in the tumor resection. However, hyperspectral imaging (HSI) is a promising non-invasive and non-ionizing imaging technique that could improve and complement the currently used methods. The HypErspectraL Imaging Cancer Detection (HELICoiD) European project has addressed the development of a methodology for tumor tissue detection and delineation exploiting HSI techniques. In this approach, the K-means algorithm emerged in the delimitation of tumor borders, which is of crucial importance. The main drawback is the computational complexity of this algorithm. This paper describes the development of the K-means clustering algorithm on different parallel architectures, in order to provide real-time processing during surgical procedures. This algorithm will generate an unsupervised segmentation map that, combined with a supervised classification map, will offer guidance to the neurosurgeon during the tumor resection task. We present parallel K-means clustering based on OpenMP, CUDA and OpenCL paradigms. These algorithms have been validated through an in-vivo hyperspectral human brain image database. Experimental results show that the CUDA version can achieve a speed-up of ~ 150 × with respect to a sequential processing. The remarkable result obtained in this paper makes possible the development of a real-time classification system.
Equivalent Resonant Circuit Modeling of a Graphene-Based Bowtie Antenna
Authors: Zhang Bin , Zhang Jingwei , Liu Chengguo , Wu Zhi P. , He Daping
Published: October 2018

The resonance performance analysis of graphene antennas is a challenging problem for full-wave electromagnetic simulators due to the trade-off between the computer resource and the accuracy of results. In this paper, an equivalent circuit model is presented to provide a concise and fast way to analyze the graphene-based THz bowtie antenna. Based on the simulated results of the frequency responses of the antenna, a suitable equivalent circuit of Resistor-Inductor-Capacitor (RLC) series is proposed to describe the antenna. Then the RLC parameters are extracted by considering the graphene bowtie antenna as a one-port resonator. Parametric analyses, including chemical potential, arm length, relaxation time, and substrate thickness, are presented based on the proposed equivalent circuit model. Antenna input resistance R is a significant parameter in this model. Validation is performed by comparing the calculated R values with the ones from full-wave simulation. By applying different parameters to the graphene bowtie antenna, a set of R, L, and C values are obtained and analyzed comprehensively. A very good agreement is observed between the equivalent model and the numerical simulation. This work sheds light on the graphene-based bowtie antenna’s initial design and paves the way for future research and applications.
Effect of Energy and Failure Rate in a Multi-Item Smart Production System
Authors: Sarkar Mitali , Sarkar Biswajit , Iqbal Muhammad Waqas
Published: October 2018

To form a smart production system, the effect of energy and machines’ failure rate plays an important role. The main issue is to make a smart production system for complex products that the system may produce several defective items during a long-run production process with an unusual amount of energy consumption. The aim of the model is to obtain the optimum amount of smart lot, the production rate, and the failure rate under the effect of energy. This study contains a multi-item economic imperfect production lot size energy model considering a failure rate as a system design variable under a budget and a space constraint. The model assumes an inspection cost to ensure product’s quality under perfect energy consumption. Failure rate and smart production rate dependent development cost under energy consumption are considered, i.e., lower values of failure rate give higher values of development cost and vice versa under the effect of proper utilization of energy. The manufacturing system moves from in-control state to out-of-control state at a random time. The theory of nonlinear optimization (Kuhn–Tucker method) is employed to solve the model. There is a lemma to obtain the global optimal solution for the model. Two numerical examples, graphical representations, and sensitivity analysis of key parameters are given to illustrate the model.
Problem Orientated Analysis on China’s Shale Gas Policy
Authors: Wang Zhong , Luo Yuyan , Li Pengchong , Cai Xiaoqian
Published: October 2018

China has accelerated the pace of shale gas development from 2010. A series of policies were issued by the Chinese government to motivate and regulate shale gas exploration and exploitation. In order to investigate the effectiveness of these policies and provide reference to the policymakers, the most relevant policies from 2010 to 2016 were collected and analyzed. Our study summarized that, in total, eight government agencies issued 25 related policies, which cover all the main problems that impede China’s shale gas industry. With the aid of these policies, the approved research and development (R&D) funds exceed 350 million Chinese yuan (CNY) ($55 million), and over 80 domestic companies participated in exploration rights bidding and nine foreign companies initiated thirteen international cooperation projects. In 2016, China’s shale gas production reached 7.88 × 109 m3, ranking third in the world. However, these policies still have some shortcomings, such as low environmental concerns, weak financial stimulus, and inefficient implementation. Therefore, we suggest that future policy should put particular emphasis on (1) formulating special environmental regulations and determining development scale based on water resource; (2) providing detailed implementation plans and maintaining stable subsidy; (3) enhancing communication and supervision; and (4) establishing a public big data platform.
Effect of Gap Sizes on Specific Leaf Area and Chlorophyll Contents at the Castanopsis kawakamii Natural Reserve Forest, China
Authors: Buajan Supaporn , Liu Jinfu , He Zhongsheng , Feng Xueping
Published: October 2018

The two hemispherical photographs (THP) method was used to calculate gap area. The areas of nine forest gaps were measured. Meanwhile, non-gap areas were selected as control groups with areas of 225 m2. Plots with areas of 25 m2 in five different directions within gap and non-gap areas were conducted for collecting leaf samples. To determine the effect of gap size on leaf traits the selected traits were leaf area (LA), leaf dry mass (LDM), specific leaf area (SLA), Chlorophyll a (Chl a), chlorophyll b (Chl b), total chlorophyll (TChl), and carotenoid (CAR). Leaves were collected from the regeneration layer (<2 cm DBH, height 2–5 m) to measure the leaf traits in winter and summer seasons. Results confirmed significant positive correlations between LA and LDM in the small, medium, large gap sizes, and non-gap areas (r2 = 0.913, 0.827, 0.897, and 0.939, p < 0.01, respectively). On the contrary, relationships between LDM and SLA in the small, medium, large gap sizes, and non-gap areas have significant negative correlations (r2 = −0.269, −0.259, −0.417, and −0.505, p < 0.05, respectively). The effect of gap size on the average Chl a, Chl b, TChl, and CAR varies by the season. During the summer season, the highest chlorophyll contents were recorded in the small gap size and the lowest in the non-gap area, while during the winter season, the highest values of these chlorophyll contents appeared in the medium gap size. Moreover, the directions within the gap in the medium gap size of the summer season had an effect on the Chl a and TChl.