bluuebunny/crossref_metadata_2025 huggingface dataset:
Bauwerkscanner zur automatisierten und kombinierten Anwendung zerstörungsfreier Prüfverfahren im Bauwesen
Authors: Taffe Alexander , Kind Thomas , Stoppel Markus , Kurz Jochen H.
Published: April 2011

Bereits seit vielen Jahren stehen Anwendern der zerstörungsfreien Prüfung im Bauwesen (ZfPBau) zuverlässige Geräte zur Untersuchung von Betonbauteilen zur Verfügung. Viele dieser Geräte zeichnen eine Messgröße in Bezug zum Messort auf und sind je nach Ausstattung in der Lage, die Ergebnisse in einem Koordinatensystem darzustellen. Doch erst die Kombination verschiedener ZfPBau‐Verfahren an einer Messfläche erlaubt den maximalen Informationsgewinn über die innere Konstruktion von Stahlbeton‐ und Spannbetonbauteilen. In dem Beitrag wird ein Bauwerkscanner zur automatisierten und kombinierten Datenaufnahme beschrieben, der erstmals die Kombination von Radar, Ultraschall und Wirbelstrom mit Datenausgabe in einem einheitlichen Koordinatensystem ermöglicht. Dieser Scanner ist im Gegensatz zu früheren Systemen technikerbasiert und erlaubt im Bedarfsfall eine spätere detaillierte Auswertung durch ZfP‐Spezialisten. Die Ergebnisse werden bildgebend in frei wählbaren Schnitten dargestellt, was bereits kurze Zeit nach der Messung auf der Baustelle möglich ist. Am Beispiel eines Brückenträgers wird gezeigt, wie der tatsächliche Spanngliedverlauf aus Messdaten ermittelt wird und dem angenommenen Verlauf gemäß Bestandsplan gegenübergestellt wird. Damit kann künftig eine Überprüfung von Bestandsplänen durchgeführt werden. Darüber hinaus könnten nicht vorhandene Bestandspläne rekonstruiert werden. Des Weiteren wird am gleichen Brückenträger gezeigt, wie sich ein echter Verpressfehler und im Unterschied dazu ein Luftspalt in einem Hüllrohr in Messdaten abbilden. An dem Beispiel wird deutlich, wie Ultraschallergebnisse in Kombination mit Phasenauswertung zur Formulierung von Verdachtsstellen für Verpressfehler eingesetzt werden können und welche Maßnahmen zur Verifizierung getroffen werden müssen.
Bemessungs‐ und Ausführungshinweise für Aufbeton auf Brückenfahrbahnplatten
Authors: Hartl Helmut , Feix Jürgen
Published: April 2011

Durch die ständige Erhöhung der Verkehrsbelastungen in den letzten Jahrzehnten und durch die Verwendung moderner Fahrzeugrückhaltesysteme sind ältere Brücken häufig nicht mehr in der Lage, ohne Verstärkungsmaßnahmen den Anforderungen des modernen Straßenverkehrs zu genügen. Eine bewährte Methode, die Tragfähigkeit einer Brücke zu erhöhen, besteht darin, auf das entsprechend vorbehandelte Rohtragwerk eine bewehrte Platte, welche mit dem Bestand kraftschlüssig verbunden ist, zu betonieren. Für die Bemessung sind der Eurocode und die in den europäisch technischen Dübelzulassungen (ETA) angegeben Bemessungsvorschriften (ETAG, TR, ...) anzuwenden. Der Anwender steht vor einer Fülle von breit gefächerten Wahlmöglichkeiten innerhalb dieser Vorschriften. Auf Basis der Erkenntnisse von mehreren Versuchsprogrammen gibt in Österreich die RVS 15.02.34 Anweisungen für die Fugenvorbereitung, die Rezeptur und den Einbau des Aufbetons und für die zugehörige Interpretation des Eurocodes und der Dübelbemessungsvorschriften bei der Bemessung der Schubfuge.

Design and Detailling of Concrete Overlays

Due to a permanent increase of traffic loads during the last decades and due to installation of modern vehicle restraint systems older bridges are often overloaded and thus have to be strengthened. Casting a concrete overlay on the existing structure is a state of the art method in order to increase the bearing capacity. The key is to prepare the interface in a way that no slip will occur between old and new concrete when forces are transferred over the interface. Mandatory for designing the concrete overlay is the Eurocode and in the European Technical Approvals (ETA) for dowels referred design guidelines (ETAG, TR, ...). However, the designer has to choose within a lot of options. On the basis of several research programs the RVS 15.02.34 gives recommendations for the preparation of the old concrete, the composition of the new concrete, casting and curing as well as choosing the associated options of the Eurocode within the structural design and detailing of the interface.
X‐ray solution scattering studies of the structural diversity intrinsic to protein ensembles
Authors: Makowski Lee , Gore David , Mandava Suneeta , Minh David , Park Sanghyun , Rodi Diane J. , Fischetti Robert F.
Published: April 2011

It is becoming increasingly clear that characterization of the protein ensemble—the collection of all conformations of which the protein is capable—will be a critical step in developing a full understanding of the linkage between structure, dynamics, and function. X‐ray solution scattering in the small angle (SAXS) and wide‐angle (WAXS) regimes represents an important new window to exploring the behavior of ensembles. The characteristics of the ensemble express themselves in X‐ray solution scattering data in predictable ways. Here we present an overview of the effect that structural diversity intrinsic to protein ensembles has on scattering data. We then demonstrate the observation of these effects in scattering from four molecular systems; myoglobin; ubiquitin; alcohol dehydrogenase; and HIV protease; and demonstrate the modulation of these ensembles by ligand binding, mutation, and environmental factors. The observations are analyzed quantitatively in terms of the average spatial extent of structural fluctuations occurring within these proteins under different experimental conditions. The insights which these analyses support are discussed in terms of the function of the various proteins. © 2011 Wiley Periodicals, Inc. Biopolymers 95: 531–542, 2011.
Polyhydroxybutyrate production from lactate using a mixed microbial culture
Authors: Jiang Yang , Marang Leonie , Kleerebezem Robbert , Muyzer Gerard , van Loosdrecht Mark C.M.
Published: March 2011

In this study we investigated the use of lactate and a lactate/acetate mixture for enrichment of poly‐3‐hydroxybutyrate (PHB) producing mixed cultures. The mixed cultures were enriched in sequencing batch reactors (SBR) that established a feast–famine regime. The SBRs were operated under conditions that were previously shown to enable enrichment of a superior PHB producing strain on acetate (i.e., 12 h cycle length, 1 day SRT and 30°C). Two new mixed cultures were eventually enriched from activated sludge. The mixed culture enriched on lactate was dominated by a novel gammaproteobacterium. This enrichment can accumulate over 90 wt% PHB within 6 h, which is currently the best result reported for a bacterial culture in terms of the final PHB content and the biomass specific PHB production rate. The second mixed culture enriched on a mixture of acetate and lactate can produce up to 84 wt% PHB in just over 8 h. The predominant bacterial species in this culture were Plasticicumulans acidivorans and Thauera selenatis, which have both been reported to accumulate large amounts of PHB. The data suggest that P. acidivorans is a specialist on acetate conversion, whereas Thauera sp. is a specialist on lactate conversion. The main conclusion of this work is that the use of different substrates has a direct impact on microbial composition, but has no significant effect on the functionality of PHB production process. Biotechnol. Bioeng. 2011;108:2022–2035. © 2011 Wiley Periodicals, Inc.
Bioartificial liver system based on choanoid fluidized bed bioreactor improve the survival time of fulminant hepatic failure pigs
Authors: Lv Guoliang , Zhao Lifu , Zhang Anye , Du Weibo , Chen Yu , Yu Chengbo , Pan Xiaoping , Zhang Yimin , Song Tao , Xu Jiansheng , Chen Yu , Li Lanjuan
Published: March 2011

Bioartificial liver (BAL) support system has been proposed as potential treatment method for end‐stage liver diseases. We described an improved BAL system based on a choanoid fluidized bed bioreactor containing alginate–chitosan encapsulated primary porcine hepatocytes. The feasibility, safety, and efficiency of this device were estimated using an allogeneic fulminant hepatic failure (FHF) model. FHF was induced with intravenous administration of D‐galactosamine. Thirty FHF pigs were divided into three groups: (1) an FHF group which was only given intensive care; (2) a sham BAL group which was treated with the BAL system with empty encapsulation, and (3) a BAL group which was treated with the BAL system containing encapsulated freshly isolated primary porcine hepatocytes. The survival times and biochemical parameters of these animals were measured, and properties of the encapsulations and hepatocytes before and after perfusion were also evaluated. Compared to the two control groups, the BAL‐treated group had prolonged the survival time and decreased the blood lactate levels, blood glucose, and amino acids remained stable. No obvious ruptured beads or statistical decline in viability or function of encapsulated hepatocytes were observed. This new fluidized bed BAL system is safe and efficient. It may represent a feasible alternative in the treatment of liver failure. Biotechnol. Bioeng. 2011;108:2229–2236. © 2011 Wiley Periodicals, Inc.
Randomized controlled trial of fibrin sealant to reduce postoperative drainage following elective lymph node dissection
Authors: Swan M C , Oliver D W , Cassell O C S , Coleman D J , Williams N , Morritt D G , Giele H P
Published: April 2011

Background

Excessive postoperative drainage following groin and axillary lymphadenectomy may be associated with a prolonged hospital stay and an increased complication rate. The use of fibrin sealant before wound closure may reduce postoperative wound drainage.

Methods

Consecutive patients undergoing elective groin or axillary lymphadenectomy were randomized to standard wound closure or to having fibrin sealant sprayed on to the wound bed before closure. Postoperative wound drainage, duration of drainage and complications were recorded, as were locoregional recurrence, distant metastasis and mortality.

Results

A total of 74 patients requiring 38 groin and 36 axillary dissections were randomized. The median postoperative wound drainage volume for the groin dissection cohort was 762 (range 25–3255) ml in the control group and 892 (265–2895) ml in the treatment group (P = 0·704). Drainage volumes in the axillary cohort were 590 (230–9605) and 565 (30–1835) ml in the control and treatment groups respectively (P = 0·217). There was no difference in the duration of drainage or postoperative complication rate between the treatment groups in both the axillary and groin cohorts. Local recurrence, distant metastasis and mortality rates did not differ between the treatment groups.

Conclusion

There was no advantage in using fibrin sealant during elective lymphadenectomy in terms of reducing drainage output or postoperative complication rate. Registration number: NCT00324272 (http://www.clinicaltrials.gov).
Hybrid aortic reconstruction for treatment of recurrent aortic obstruction after stage 1 single ventricle palliation: Medium term outcomes and results of redilation
Authors: Kutty Shelby , Burke Redmond P. , Hannan Robert L. , Zahn Evan M.
Published: March 2011

Objective:

We describe a hybrid approach to the treatment of aortic obstruction after stage 1 palliation (S1P) of hypoplastic left heart syndrome.

Background:

Recurrent aortic obstruction is a common problem after S1P of hypoplastic left heart syndrome. Even mild aortic obstruction is poorly tolerated so early and definitive therapy is desirable. Although stent implantation is an effective treatment for aortic obstruction in older children and adults, technical issues due to small vessels and concerns regarding future potential for expansion have generally precluded the use of stents in this setting.

Methods:

Six patients underwent hybrid aortic reconstruction (HAR) in the operating room or catheterization laboratory, with the interventional cardiologist and cardiac surgeon working in cooperation.

Results:

Patients had a mean weight of 5.8 kg (2.9–7.7) and a mean age of 5.6 months (0.5–12.9) at the time of HAR. Five patients had undergone prior balloon angioplasty at a mean age of 2.8 months (2.1–3.5), and five had moderately depressed single ventricular function prior to HAR. The balloons used had a diameter of 7–10 mm and introducer sheath size ranged from 6 to 10 F. There were no immediate or late procedure related complications. Stent redilation was performed in 5 patients for relief of recurrent obstruction or to keep pace with somatic growth. At a median follow up of 4.8 years (0.2–7.9), there were 3 patients progressing well after Fontan palliation and 3 deaths.

Conclusions:

HAR allows for placement of stents that can ultimately reach adult size in small infants who have recurrent aortic obstruction after balloon angioplasty following S1P. Advantages include freedom from delivery sheath constraints when determining stent type/size, facilitation of precise stent position, and avoidance of vascular damage or hemodynamic compromise during the procedure. Longer follow‐up and larger experience are required to determine if this therapy will provide a long‐term solution to this difficult problem. © 2011 Wiley‐Liss, Inc.
Hydrodynamic Behaviors in Gas‐Solid Two‐Phase Magnetic Fluidized Beds 1. Experimental Results Represented by a Dimensionless Number
Authors: Li H. , Cao C. , Zhao Y.
Published: April 2011

The influence of magnetic field intensity and process parameters on the transient fluidization behaviors of magnetically stable fluidized beds (MSFBs) was studied. The local solid holdup distribution and magnetically stabilized regimes were carried out by experimental measurements in MSFBs. The scaling approach for MSFB hydrodynamics based on magnetic field and dynamic similitude with a limited number of dimensionless groups was tested. A dimensionless number for magnetic field has been developed. An experimental criterion for the magnetically stabilized fluidization is established based on random analysis of the void fluctuation signal. It includes two characteristic parameters of the main frequency of voidage fluctuation signals, i.e., the self‐correlation function and variance. A dimensionless correlation to calculate the stable zone with three dimensionless groups of Er, Ar, and Re was proposed using dimensionless analysis.
Nucleotide Recognition in Water by a Guanidinium‐Based Artificial Tweezer Receptor
Authors: Kuchelmeister Hannes Y. , Schmuck Carsten
Published: April 2011

The water‐soluble tweezer receptor 1 with two symmetric peptidic arms, which are connected by an aromatic scaffold and contain lysine, phenylalanine, and a guanidinium‐based anion‐binding site as headgroup, has been synthesized. UV/Vis‐derived Job plots show that the receptor forms 1:1 complexes with nucleotides and phosphate in buffered water at neutral pH. Binding constants have been determined by fluorescence and UV/Vis spectroscopy. All nucleotides tested were bound very efficiently, even in pure water, with binding constants between 104 and 105 M−1. Interestingly, all mononucleotides were bound much stronger than phosphate by a factor of at least 5 to 10. Furthermore 1 favors the binding of adenosine monophosphate (AMP) over adenosine diphosphate (ADP) and adenosine triphosphate (ATP), which is unprecedented for artificial nucleotide receptors reported so far. According to NMR spectroscopy and molecular modeling studies, the efficient binding is a result of strong electrostatic contacts supported by π–π interactions with the nucleobase within the cavity‐shaped receptor.
Difunctionalisation of Arenes and Heteroarenes by Directed Metallation and Sulfoxide–Magnesium Exchange
Authors: Melzig Laurin , Rauhut Christian B. , Naredi‐Rainer Nikolaus , Knochel Paul
Published: April 2011

The aryl sulfoxide moiety allows an expedient two‐step difunctionalisation of readily available diaryl sulfoxides. Highly functionalised 1,2,4‐trisubstituted arenes and difunctionalised heteroarenes (furans, thiophenes, benzofurans and pyridines) were prepared in a two‐step sequence, triggered by an aryl sulfoxide group. In the first step, the sulfoxide moiety acts as a metallation‐directing group, allowing smooth ortho‐magnesiation with TMPMgCl⋅LiCl (TMP=tetramethylpiperidine). After a quenching reaction with an electrophile, the resulting sulfoxide is converted into a second magnesium reagent with iPrMgCl⋅LiCl (sulfoxide–magnesium exchange), which can be trapped with various electrophiles. Highly chemoselective TMPMgCl⋅LiCl and iPrMgCl⋅LiCl are compatible with a broad range of functional groups (e.g., F, Cl, CF3, CN, CO2tBu, alkynyl, ethers, thioethers). Large‐scale reactions (25–40 mmol) and the preparation of fully functionalised furans and thiophenes are also reported.
ChemInform Abstract: Structural Principles of Semiconducting Group 14 Clathrate Frameworks.
Authors: Karttunen Antti J. , Faessler Thomas F. , Linnolahti Mikko , Pakkanen Tapani A.
Published: March 2011

The basic clathrate frameworks, together with their polytypes, intergrowth clathrate frameworks, and extended frameworks based on larger icosahedral building blocks of carbon, silicon, germanium, and tin are investigated by quantum chemical DFT computations.
ChemInform Abstract: An Aqueous‐Solution Based Low‐Temperature Pathway to Synthesize Giant Dielectric CaCu3Ti4O12 — Highly Porous Ceramic Matrix and Submicron Sized Powder.
Authors: Banerjee Nirupam , Krupanidhi S. B.
Published: March 2011

A microporous CaCu3Ti4O12 matrix is obtained from an aqueous solution containing Ti(OiPr)4, HNO3, Ca(NO3)2, and Cu(NO3)2 (1.
ChemInform Abstract: Properties and High‐Pressure Behavior of a Ternary Lead Oxide Pb2MnO4.
Authors: Serier‐Brault Helene , Jansen Martin
Published: March 2011

Pb2MnO4 and Sr‐doped Pb2MnO4 powders are synthesized by a polyesterification reaction based on the Pechini process using metal nitrates, citric acid, and ethylene glycol as starting materials.
ChemInform Abstract: A Novel Catalyst Precursor K2TiF6 with Remarkable Synergetic Effects of K, Ti and F Together on Reversible Hydrogen Storage of NaAlH4.
Authors: Liu Yongfeng , Liang Chu , Zhou Hai , Gao Mingxia , Pan Hongge , Wang Qidong
Published: March 2011

The new additive K2TiF6 remarkably improves the hydrogen storage performance of NaAlH4 due to the synergetic catalytic effect of K, Ti, and F.
ChemInform Abstract: New Quaternary Hydride CeZnSnH1.5: Structure, Magnetism, and Chemical Bonding.
Authors: Hermes Wilfried , Chavalier Bernard , Rodewald Ute Ch. , Matar Samir F. , Weill Francois , Schellenberg Inga , Poettgen Rainer , Lueken Heiko , Speldrich Manfred
Published: March 2011

The title compound is prepared from a CeZnSn precursor (obtained by induction melting of the elements in a sealed Ta ampule) upon hydrogenation at 553 K and 4 MPa H2.
ChemInform Abstract: A New Organic—Inorganic Hybrid Layered Molybdenum(V) Cobalt Phosphate Constructed from [H24(Mo16O32)Co16 (PO4)24(OH)4 (C5H4N)2(H2O)6] 4‐ Wheels and 4,4′‐Bipyridine Linkers.
Authors: Yu Kai , Zhou Bai‐Bin , Yu Yang , Su Zhan‐Hua , Yang Guo‐Yu
Published: March 2011

The novel layered phosphate (III) crystallizes in the monoclinic space group P21/n with Z = 2 (single crystal XRD).
ChemInform Abstract: Preparation and Thermoelectric Properties of AgPb18‐xSnxSbTe20 (x = 0.5, 1, 2, 4, 6) Materials.
Authors: Li H. , Cai K. F. , Wang H. F. , Li X. L. , Wang Y. Y. , Zhou C. W.
Published: March 2011

The title compounds are hydrothermally synthesized from aqueous mixtures of AgNO3, Pb(NO3)2, SnCl2, SbCl3, TeO2, KOH, and KBH4 (autoclave, 180 °C, 20 h) followed by melting at 1273 K for 5 h.
ChemInform Abstract: Axially Chiral C2‐Symmetric N‐Heterocyclic Carbene (NHC) Palladium Complex‐Catalyzed Asymmetric α‐Hydroxylation of β‐Keto Esters.
Authors: Cao Shu‐Hua , Shi Min
Published: March 2011

The asymmetric hydroxylation of indan‐1‐one‐2‐carboxylates using phenyloxaziridine as oxidant is catalyzed by a novel axially chiral NHC—Pd catalyst (BINCAP).
ChemInform Abstract: Synthesis of 5‐Arylidene‐2,4‐thiazolidinediones by Knoevenagel Condensation Catalyzed by Baker′s Yeast.
Authors: Pratap Umesh R. , Jawale Dhanaji V. , Waghmare Rahul A. , Lingampalle Dinesh L. , Mane Ramrao A.
Published: March 2011

Baker′s yeast offers an eco‐friendly protocol for the Knoevenagel condensation of aromatic aldehydes with active methylene compounds.
ChemInform Abstract: Ni‐Catalyzed Reduction of Inert C—O Bonds: A New Strategy for Using Aryl Ethers as Easily Removable Directing Groups.
Authors: Alvarez‐Bercedo Paula , Martin Ruben
Published: March 2011

The method is characterized by its simplicity, wide preparative scope, and the availability of the substrates employed.
ChemInform Abstract: Synthesis of Oxygen Heterocycles by Regioselective Heck Reaction.
Authors: McConville Matthew , Ruan Jiwu , Blacker John , Xiao Jianliang
Published: March 2011

Regioselective Heck arylation of unsaturated alcohols followed by cyclization affords 2,2‐disubstituted tetrahydrofurans and tetrahydropyrans in a convenient one‐pot fashion.
ChemInform Abstract: Accessing the Antipodal Series in Microbial Arene Oxidation: A Novel Diene Rearrangement Induces by Tricarbonyliron(0) Complexation.
Authors: Khan Monika Ali , Lowe John P. , Johnson Andrew L. , Stewart Alan J. W. , Lewis Simon E.
Published: March 2011

The complexation of acetonide (I) with tricarbonyliron is accompanied by an isomerization to afford complex (III).
ChemInform Abstract: Creation of a High‐Valent Manganese Species on Hydrotalcite and Its Application to the Catalytic Aerobic Oxidation of Alcohols.
Authors: Nagashima Kohji , Mitsudome Takato , Mizugaki Tomoo , Jitsukawa Koichiro , Kaneda Kiyotomi
Published: March 2011

A high‐valent Mn oxide species is synthesized on the surface of hydrotalcite by treatment of the corresponding Mn compound with KOH.
ChemInform Abstract: A Simple and Effective Method for α‐Hydroxylation of β‐Dicarbonyl Compounds Using Oxone as an Oxidant Without a Catalyst.
Authors: Yu Jun , Cui Jian , Zhang Chi
Published: March 2011

A wide variety of cyclic β‐dicarbonyl compounds is efficiently hydroxylated at the α‐position simply using Oxone without catalyst.
ChemInform Abstract: Efficient Carboazidation of Alkenes Using a Radical Desulfonylative Azide Transfer Process.
Authors: Weidner Karin , Giroult Andre , Panchaud Philippe , Renaud Philippe
Published: March 2011

In this paper a new class of reagents that allows an atom‐economical carboazidation reaction to be run under tin‐free conditions is prepared.
ChemInform Abstract: A One‐Pot Conversion of Carboxylic Acids into Nitriles Catalyzed by PEG400 under Microwave Irradiation.
Authors: Cao Yu‐Qing , Qu An‐Li , Liu Rui‐Yan , Duan Chun‐Ming
Published: March 2011

The new efficient title method is inexpensive, practical, with less pollution and includes an easy work‐up.
ChemInform Abstract: General and Highly Active Catalyst for Mono and Double Hiyama Coupling Reactions of Unreactive Aryl Chlorides in Water.
Authors: Lee Dong‐Hwan , Jung Ji‐Young , Jin Myung‐Jong
Published: March 2011

A new β‐ketiminatophosphane Pd‐complex is found to be highly effective in the mono and double Hiyama coupling reactions of unactivated aryl chlorides (I), (IV) and (VII).
ChemInform Abstract: Bimetallic Catalysis Involving Dipalladium(I) and Diruthenium(I) Complexes.
Authors: Das Raj K. , Saha Biswajit , Rahaman S. M. Wahidur , Bera Jitendra K.
Published: March 2011

A binuclear Pd catalyst containing amide‐tethered naphthyridinylferrocene ligands as well as a similar binuclear Ru catalyst are synthesized.
ChemInform Abstract: A General and Efficient Iridium‐Catalyzed Hydroformylation of Olefins.
Authors: Piras Irene , Jennerjahn Reiko , Jacksell Ralf , Spannenberg Anke , Franke Robert , Beller Matthias
Published: March 2011

An iridium—phosphine complex efficiently catalyzes the hydroformylation of terminal olefins to predominantly give linear aldehydes from aliphatic olefins (Ib) ‐ (Ie), but branched aldehydes from aromatic olefin (Ia).
ChemInform Abstract: Ligand‐Assisted Rate Acceleration in Lanthanum(III) Isopropoxide Catalyzed Transesterification of Carboxylic Esters.
Authors: Hatano Manabu , Furuya Yoshiro , Shimmura Takumi , Moriyama Katsuhiko , Kamiya Sho , Maki Toshikatsu , Ishihara Kazuaki
Published: March 2011

The catalyst is effective in the selective esterification of a variety of primary, secondary and tertiary alcohols including sterically demanding ones.
ChemInform Abstract: Regioselective Alkylation of Catechols via Mitsunobu Reactions.
Authors: Wang Xiaolong , Ju Tingting , Li Xiaodong , Cao Xiaoping
Published: March 2011

Catechols (I) bearing an electron‐withdrawing substituent are para‐alkylated with high regioselectivity and in good yields.
ChemInform Abstract: Iron‐Catalyzed Reductive Aryl—Alkenyl Cross‐Coupling Reactions.
Authors: Czaplik Waldemar M. , Mayer Matthias , Jacobi von Wangelin Axel
Published: March 2011

The simple precatalyst system FeCl3/TMEDA is effectively applied to cross‐coupling reactions of various arylmagnesium bromides and alkenyl bromides.
ChemInform Abstract: Efficient Ligand‐Free Copper‐Catalyzed Arylation of Aliphatic Amines.
Authors: Yong Fui‐Fong , Teo Yong‐Chua
Published: March 2011

A facile synthesis of aromatic amines is achieved by cross‐coupling of primary or secondary amines with aryl iodides.
ChemInform Abstract: Efficient and Clean Gold‐Catalyzed One‐Pot Selective N‐Alkylation of Amines with Alcohols.
Authors: He Lin , Lou Xia‐Bing , Ni Ji , Liu Yong‐Mei , Cao Yong , He He‐Yong , Fan Kang‐Nian
Published: March 2011

A wide range of aromatic and aliphatic tertiary amines is prepared using Au‐TiO2 with very small particles.
ChemInform Abstract: (Cyclopentadienyl)ruthenium‐Catalyzed Regio‐ and Enantioselective Decarboxylative Allylic Etherification of Allyl Aryl and Alkyl Carbonates.
Authors: Austeri Martina , Linder David , Lacour Jerome
Published: March 2011

The combination of a ruthenium complex with chiral pyridyloxazoline ligand POX catalyzes the title intra‐ or intermolecular reactions with high enantioselectivities and high regioselectivities for the branched products.
ChemInform Abstract: 1,3‐Bis(2,4,6‐trimethylphenyl)imidazolium Chloride in Combination with Triethylamine: An Improved Catalytic System for Hydroacylation/Reduction of Activated Ketones.
Authors: Sreenivasulu M. , Kumar K. Arun , Reddy K. Sateesh , Kumar K. Siva , Kumar P. Rajender , Chandrasekhar K. B. , Pal Manojit
Published: March 2011

A combination of triethylamine and an NHC‐catalyst, generated in situ, efficiently promotes the reduction of α‐keto esters with benzaldehyde as hydrogen acceptor.
ChemInform Abstract: Direct Oxidative Conversion of Alcohols, Aldehydes and Amines into Nitriles Using Hypervalent Iodine(III) Reagent.
Authors: Zhu Chenjie , Sun Chengguo , Wei Yunyang
Published: March 2011

A simple oxidative protocol is developed for the conversion of alcohols, aldehydes, and different amines.
ChemInform Abstract: Palladium‐Catalyzed Aminosulfonylation of Aryl Halides.
Authors: Nguyen Bao , Emmett Edward J. , Willis Michael C.
Published: March 2011

The palladium‐catalyzed three‐component coupling of aryl iodides, sulfur dioxide, and hydrazines is described.
ChemInform Abstract: Nickel‐Catalyzed Cross‐Coupling Reaction of Aryl(trialkyl)silanes with Aryl Chlorides and Tosylates.
Authors: Tang Shi , Takeda Masahide , Nakao Yoshiaki , Hiyama Tamejiro
Published: March 2011

Arylsilanes (V) are readily prepared from silane (III) and successfully used as arylating agents in the cross‐coupling reaction with tosylates (VIa)—(VIc) and chlorides (VId)—(VIj).
ChemInform Abstract: Lewis‐Acid‐Mediated Domino Reactions of Bis(diacetoxymethyl)‐Substituted Arenes and Heteroarenes.
Authors: Clement J. Arul , Sivasakthikumaran Ramakrishnan , Mohanakrishnan Arasambattu K. , Sundaramoorthy S. , Velmurugan Devadasan
Published: March 2011

The domino reaction of aryl or heteroaryl tetraacetates with heteroarenes in the presence of Lewis acid affords annulated heteroarenes.
ChemInform Abstract: A Flexible Route to 4‐Substituted β‐Lactams.
Authors: Quiclet‐Sire Beatrice , Zard Samir Z.
Published: March 2011

A variety of 4‐substituted β‐lactams are synthesized by radical addition‐transfer of N‐acyl‐protected 4‐S‐xanthylazetidinones to unactivated olefins.
ChemInform Abstract: Cu2O Nanocubes Catalyzed Difunctionalization Reaction of Vinyl Arenes with Cyclic Ethers.
Authors: Kim Jee Young , Park Ji Chan , Song Hyunjoon , Park Kang Hyun
Published: March 2011

Well designed, uniform Cu2O nanoparticles catalyze the regioselective oxyalkylation of various vinyl arenes under mild conditions.
ChemInform Abstract: One‐Pot Synthesis of Furans from Isoxazolines with Iron as Reducing Agent.
Authors: Jiang Dahong , Chen Yuanwei
Published: March 2011

Isoxazolines (I) serve as precursors for the preparation of substituted furans (II) through a sequential reduction/hydrolysis/cyclocondensation reaction.
ChemInform Abstract: Dynamic Kinetic Asymmetric Domino Oxa‐Michael/Carbocyclization by Combination of Transition‐Metal and Amine Catalysis: Catalytic Enantioselective Synthesis of Dihydrofurans.
Authors: Lin Shuangzheng , Zhao Gui‐Ling , Deiana Luca , Sun Junliang , Zhang Qiong , Leijonmarck Hans , Cordova Armando
Published: March 2011

The highly enantioselective reaction is promoted by PdCl2 and proline‐derived organocatalyst with PhCOOH as an additive.
ChemInform Abstract: Multiple Approaches to Enantiopure Spirocyclic Benzofuranones Using Organocatalytic Cascade Reactions.
Authors: Cassani Carlo , Tian Xu , Escudero‐Adan Eduardo C. , Melchiorre Paolo
Published: March 2011

Three distinct aminocatalytic cascade reactions leading to enantiomerically pure spirocyclic benzofuranones ar developed.
ChemInform Abstract: Convergent Approach to Nonsymmetrical 2,5‐Diester Pyrroles.
Authors: Levesque Eric , Campeau Louis‐Charles , Gauvreau Danny
Published: March 2011

The synthesis of title pyrroles (IV) is based on a Rh‐catalyzed NH‐insertion followed by a one‐pot zinc‐mediated deprotection cyclization sequence.
ChemInform Abstract: Rhodium/Diene‐Catalyzed Asymmetric Arylation of N‐Sulfonyl Indolylimines: A New Access to Highly Optically Active α‐Aryl 3‐Indolyl‐methanamines.
Authors: Yang Hong‐Yu , Xu Ming‐Hua
Published: March 2011

The first example of catalytic asymmetric arylation of title compounds (I) by using Rh(I) and bicyclo[3.3.0]diene ligand is reported.
ChemInform Abstract: The First Syntheses of Enantiopure 2,2′‐Biindoline.
Authors: Wales Steven M. , Willis Anthony C. , Keller Paul A.
Published: March 2011

The first two syntheses of enantiopure 2,2′‐biindoline (V) using bioxirane (II) and biaziridine (VI) as the chiral precursors are described.
ChemInform Abstract: Efficient and Metal‐Free Friedel—Crafts Alkylation of Indoles with Allyl Acetate Mediated by TFE.
Authors: Liu Zhe , Liu Li , Wu Yan‐Chao , Wang Dong
Published: March 2011

The chemoselective Friedel—Crafts allylation of indoles (I) and (IV) proceeds under mild conditions in trifluoroethanol providing the corresponding C‐3 allylated products in satisfactory to very good yields.
ChemInform Abstract: Iron/Palladium‐Catalyzed Intramolecular Hydroamination: An Expedient Synthesis of Pyrrole‐Annulated Coumarin and Quinolone Derivatives.
Authors: Majumdar K. C. , De Nirupam , Roy B.
Published: March 2011

A straightforward and high‐yielding approach to the heterocyclic skeletons is achieved through a Pd/Fe‐catalyzed cyclization of acetylenic amines of type (I) and (III).
ChemInform Abstract: A Concise and Flexible Diastereoselective Approach to Heteroring‐Fused Isoindolinones.
Authors: Ahn Gang , Lorion Magali , Agouridas Vangelis , Couture Axel , Deniau Eric , Grandclaudon Pierre
Published: March 2011

A sequence involving metalation of N‐chloroalkylated isoindolinones (I) and (IV), subsequent interception with aldehydes (II) or tosylimine (V) and ultimate intramolecular annulation allows the diastereoselective synthesis of the title compounds (III) and (VI).
ChemInform Abstract: Synthesis and Molecular Modeling Studies of Antiinflammatory Active 1H‐Pyrrolizine‐5‐carboxamides.
Authors: Barsoum Flora F.
Published: March 2011

Intermediate (III) is used as starting material for a variety of title compounds which are screened for their antiinflammatory activities.
ChemInform Abstract: Synthesis of 2,2′‐(2‐Oxoimidazolidine‐4,5‐diylidene)diacetates.
Authors: Mukovoz P. P. , Kozminykh V. O. , Nozdrin I. N. , Kozminykh E. N.
Published: March 2011

Compound (II), which can be prepared by condensation of 2 equiv.
ChemInform Abstract: Simple Three Steps Synthesis of Potential Medicine for Metabolic Syndrome.
Authors: Adachi Kazuhiro , Michigami Kyosuke , Hayashi Masahiko
Published: March 2011

A short synthesis of the potential medicinal derivatives of JTP‐426467 (VIc), which can be easily obtained by recrystallization, is presented.
ChemInform Abstract: Unexpected Regioselectivity in Cycloisomerization of 2‐Alkynyl‐3‐nitrothiophenes.
Authors: Cikotiene Inga , Sazinas Rokas , Mazeikaite Rita , Labanauskas Linas
Published: March 2011

Optimized reaction conditions using AuCl3 or silver trifluoroacetate as the catalyst are developed for the cycloisomerization of 2‐alkynyl‐3‐nitrothiophenes (I) or the corresponding isomers (III) to give thienoisoxazoles (II) and (IV) in moderate to good yields.
ChemInform Abstract: α,α‐Diarylprolinol‐Derived Chiral Ionic Liquids: Recoverable Organocatalysts for the Domino Reaction Between α,β‐Enals and N‐Protected Hydroxylamines.
Authors: Maltsev Oleg V. , Kucherenko Alexandr S. , Chimishkyan Alexandr L. , Zlotin Sergei G.
Published: March 2011

Diarylprolinol‐derived chiral ionic liquid (IPROS) represents a novel efficient organocatalyst for the domino reaction of α,β‐enals with hydroxylamines.
ChemInform Abstract: Direct Preparation of Heteroaromatic Compounds from Alkenes.
Authors: Donohoe Timothy J. , Kabeshov Mikhail A. , Rathi Akshat H. , Smith Ian E. D.
Published: March 2011

Aromatic heterocycles, such as thiazoles (III), imidazoles (V) and indole derivative (VII) are synthesized directly from alkenes (I) via a ketoiodination—cyclization protocol.
ChemInform Abstract: Simple Selective Synthesis of 2,4‐ and 2,6‐Diarylpyridines Through Metal‐Free Cyclocondensation of Aromatic Ketones with Ammonium Acetate.
Authors: Liu Jin , Wang Chuanxin , Wu Liansheng , Liang Fen , Huang Guosheng
Published: March 2011

Under optimized conditions, acetophenones (I) and analogous ketones (III) afford 2,4‐ and 2,6‐diarylpyridines, respectively.
ChemInform Abstract: Gold(I)‐Catalyzed Formation of Dihydroquinolines and Indoles from N‐Aminophenyl Propargyl Malonates.
Authors: Gronnier Colombe , Odabachian Yann , Gagosz Fabien
Published: March 2011

An efficient synthesis of exo‐methylenetetrahydroquinolines [cf.
ChemInform Abstract: Novel, Versatile Three‐Step Synthesis of 1,2,3,4,10,10a‐Hexahydropyrazino[1,2‐a]indoles by Intramolecular Carbene‐Mediated C—H Insertion.
Authors: Krogsgaard‐Larsen Niels , Begtrup Mikael , Herth Matthias M. , Kehler Jan
Published: March 2011

The synthesis of title compounds (V) is based on an intramolecular carbene‐mediated C—H insertion in phenylpiperazine‐derived tosylhydrazones.
ChemInform Abstract: Synthesis of Substituted 4‐Oxo‐3,4‐dihydrothieno[3,4‐d]pyrimidines and Comparison of Their Properties with Those of Positionally Isomeric Thienopyrimidinones and Benzo Isosteres.
Authors: Zadorozhny A. V. , Turov A. V. , Kovtunenko V. A.
Published: March 2011

Title compound (III) is prepared by a new method giving increased yield.
ChemInform Abstract: An Alternative Synthesis of 2‐Alkylidene‐3,4‐dihydro‐2H‐1,4‐benzoxazines by Intramolecular Gold‐Catalyzed Hydroalkoxylation of 2‐(Prop‐2‐yn‐1‐ylamino)phenols.
Authors: Manzo Angelo M. , Perboni Alcide , Broggini Gianluigi , Rigamonti Micol
Published: March 2011

Cyclizations of substrates (I) and (III) under conditions A) gives the target benzoxazines.
ChemInform Abstract: 1,2,4‐Triazines — Products of Reaction of Thiocarbohydrazide and Its Alkyl(Aryl)‐Substituted Derivatives with 1,2‐Dicarbonyl Compounds.
Authors: Alekseyev V. V. , Lagoda I. V. , Yakimovich S. I. , Yegorova M. B.
Published: March 2011

The reaction of thiocarbohydrazides (I) with 1,2‐dicarbonyl compounds of type (II) or (IV) leads to the formation of triazines.
ChemInform Abstract: Asymmetric Induction in the Reactions of Azinones with C‐Nucleophiles.
Authors: Chupakhin O. N. , Egorov I. N. , Rusinov V. L. , Slepukhin P. A.
Published: March 2011

The reactions of triazinones (I) and (VII) with amino acid chlorides and indole lead to diastereomerically pure adducts (VI) and (X), respectively.
ChemInform Abstract: Rhodium‐Catalyzed Allene Amidation: A Facile Entry into 2‐Amidoallylcations for Unusual [3 + 3] Annulation Reactions.
Authors: Stoll Armin H. , Blakey Simon B.
Published: March 2011

Regio‐ and stereoselective [3 + 3] cycloaddition reactions initiated by allene sulfamidation provide highly functionalized heterocycles in a modular fashion.
ChemInform Abstract: A Convenient Synthetic Route from Isatin N‐Mannich Bases to Nitrogen‐Containing Derivatives of Isoindigo.
Authors: Bogdanov Andrei V. , Mironov Vladimir F. , Musin Lenar I. , Musin Rashid Z. , Krivolapov Dmitry B. , Litvinov Igor A.
Published: March 2011

This simple procedure involves a novel deoxygenation reaction of isatins (I) with hexaethylphosphorous triamide furnishing the bis(aminomethyl)isoindigos (II) under mild conditions in a short reaction time.
ChemInform Abstract: Synthetic Studies of Superstolide A: A Carbohydrate Based Synthesis of the C21—C26 Segment.
Authors: Pal Rita , Rahaman Hasibur , Mohapatra D. K. , Gurjar Mukund K.
Published: March 2011

A chiral pool approach to the title segment (IX) is disclosed in which the key fragment (VII), obtained from D‐glucose diacetonide, plays a central role serving not only as the source of the C23‐C26 stereocenters but also sets the stage for introducing the C22 stereocenter through regio‐ as well as stereospecific hydroboration oxidation protocol with regard to the exo‐methylenic group in (VII).
ChemInform Abstract: Development of Novel Proton Conductors Consisting of Solid Acid/Pyrophosphate Composite for Intermediate‐Temperature Fuel Cells
Authors: Matsui Toshiaki , Muroyama Hiroki , Kikuchi Ryuji , Eguchi Koichi
Published: March 2011

Review: 32 refs.
ChemInform Abstract: Multiferroic Double Perovskites: Opportunities, Issues and Challenges
Authors: Singh M. P. , Truong K. D. , Jandl S. , Fournier P.
Published: March 2011

Review: emphasis on La2NiMnO6 as a prototype; 30 refs.
ChemInform Abstract: Lithium‐Transition Metal‐Tetrelides ‐ Structure and Lithium Mobility
Authors: Poettgen Rainer , Dinges Tim , Eckert Hellmut , Sreeraj Puravankara , Wiemhoefer Hans‐Dieter
Published: March 2011

Review: 124 refs.
ChemInform Abstract: From the pH Scale to the pO Scale. The Problem of the Determination of the Oxygen Ion O2‐ Activity in Oxide Melts
Authors: Konakov Vladimir G.
Published: March 2011

Review: 83 refs.
ChemInform Abstract: A Simple, Rational Method to Prepare Nanodispersed Metal Catalysts Supported on Silica
Authors: Regalbuto John R.
Published: March 2011

Review: 140 refs.
ChemInform Abstract: σ‐Acceptor, Z‐Type Ligands for Transition Metals
Authors: Amgoune Abderrahmane , Bourissou Didier
Published: March 2011

Review: 105 refs.
ChemInform Abstract: Reflections on Future Directions in Organometallic Electrochemistry
Authors: Geiger William E.
Published: March 2011

Review: 52 refs.
ChemInform Abstract: The Chemistry of Azaazulenes
Authors: Abe Noritaka , Gunji Takahiro
Published: March 2011

Review: synthetic methods and reactions of azaazulenes including some of their dihydro‐, oxo‐, and hetero‐fused derivatives published during 2000 to early in 2010; 79 refs.
ChemInform Abstract: Automated Solid‐Phase Synthesis of Oligosaccharides
Authors: Eller Steffen , Weishaupt Markus , Seeberger Peter H.
Published: March 2011

Review: 12 refs.
ChemInform Abstract: Discovery of ZACA Reaction : Zr‐Catalyzed Asymmetric Carboalumination of Alkenes
Authors: Negishi Ei‐ichi
Published: March 2011

Review: 94 refs.
ChemInform Abstract: Homogenous Asymmetric Hydrogenation: Recent Trends and Industrial Applications
Authors: Palmer Andreas M. , Zanotti‐Gerosa Antonio
Published: March 2011

Review: 99 refs.
ChemInform Abstract: Cross‐Metathesis in Natural Products Synthesis
Authors: Prunet Joelle , Grimaud Laurence
Published: March 2011

Review: 69 refs.
ChemInform Abstract: Temporary Silicon‐Tethered Ring‐Closing Metathesis Reactions in Natural Product Synthesis
Authors: Evans P. Andrew
Published: March 2011

Review: 92 refs.
ChemInform Abstract: An Organic Chemist′s Perspective on High Temperature Molten Salts and Room Temperature Ionic Liquids
Authors: Pagni Richard M.
Published: March 2011

Review: 57 refs.
ChemInform Abstract: Regulated Systems for Catalyst Immobilisation Based on Supercritical Carbon Dioxide
Authors: Langanke Jens , Leitner Walter
Published: March 2011

Review: 34 refs.
ChemInform Abstract: Building a Bridge Between Peptide Chemistry and Organic Chemistry: Intramolecular Macrocyclization Reactions and Supramolecular Chemistry with Helical Peptide Substrates
Authors: Moretto Alessandro , Crisma Marco , Formaggio Fernando , Toniolo Claudio
Published: March 2011

Review: 58 refs.
ChemInform Abstract: New Perspective in Peptide Chemistry by N‐Alkylation
Authors: Kessler Horst , Chatterjee Jayanta , Doedens Lucas , Operrer Florian , Biron Eric , Hoyer Daniel , Schmid Herbert , Gilon Chaim , Hruby Victor J. , Mierke Dale F.
Published: March 2011

Review: 9 refs.
ChemInform Abstract: Synthesis of Glycopolymers and Their Multivalent Recognitions with Lectins
Authors: Ting S. R. Simon , Chen Gaojian , Stenzel Martina H.
Published: March 2011

Review: 165 refs.
ChemInform Abstract: Designing Polymeric Particles for Antigen Delivery
Authors: De Koker Stefaan , Lambrecht Bart N. , Willart Monique A. , Van Kooyk Yvette , Grooten Johan , Vervaet Chris , Remon Jean Paul , De Geest Bruno G.
Published: March 2011

Review: 137 refs.
ChemInform Abstract: Control of Nano/Molecular Systems by Application of Macroscopic Mechanical Stimuli
Authors: Ariga Katsuhiko , Mori Taizo , Hill Jonathan P.
Published: March 2011

Review: 97 refs.
ChemInform Abstract: Mechanized Materials
Authors: Boyle Megan M. , Smaldone Ronald A. , Whalley Adam C. , Ambrogio Michael W. , Botros Youssry Y. , Stoddart J. Fraser
Published: March 2011

Review: 113 refs.
ChemInform Abstract: Where Are Ionic Liquid Strategies Most Suited in the Pursuit of Chemicals and Energy from Lignocellulosic Biomass?
Authors: Sun Ning , Rodriguez Hector , Rahman Mustafizur , Rogers Robin D.
Published: March 2011

Review: 97 refs.
ChemInform Abstract: Orbital Phase Design of Diradicals
Authors: Ma Jing , Inagaki Satoshi , Wang Yong
Published: March 2011

Review: 164 refs.
ChemInform Abstract: Mastering Fundamentals of Supramolecular Design with Carboxylic Acids. Common Lessons from X‐Ray Crystallography and Scanning Tunneling Microscopy
Authors: Ivasenko Oleksandr , Perepichka Dmitrii F.
Published: March 2011

Review: 74 refs.
Mai – Ein Prosit auf den Wonnemonat
Authors: Hatscher Deike , Knirsch Sandra
Published: March 2011

Im Mai gibt es zahlreiche kulinarische Traditionen wie beispielsweise der Genuss der Maibowle. Dieses auch Maiwein oder Maitrunk genannte Weinmischgetränk fand bereits 854 – vor also über 1150 Jahren – in klösterlichen Schriften als Stärkungsmedizin Erwähnung. Typisch ist die Zubereitung für den Mai, da zu dieser Zeit der Waldmeister, der auch Maikraut genannt wird, am aromaträchtigsten ist.
Examining the Dual Forces of Individual Entrepreneurial Orientation and Liability of Foreignness on International Entrepreneurs
Authors: Joardar Arpita , Wu Sibin
Published: March 2011

In this paper, we adopt a theoretical approach to integrate two streams of literature—that is, entrepreneurship orientation (EO) and liability of foreignness (LOF)—to examine the dual effect of EO and foreignness on international entrepreneurs. First, we argue for the need for developing the constructs of EO and LOF at the individual level (referred to as IEO and ILOF, respectively), as previous research has primarily examined them at the firm level. Then, we develop a 4S framework to characterize entrepreneurs based on their EO and foreignness into four categories—star, survivor, struggler, and slider—and offer predictions on their relative performance. Copyright © 2011 ASAC. Published by John Wiley & Sons, Ltd.
Fixed bed column adsorption of ACID Yellow 17 dye onto Tamarind Seed Powder
Authors: Patel Himanshu , Vashi R. T.
Published: April 2011

The intention of this study was to explore the efficacy and feasibility for Acid Yellow 17 adsorption onto fixed bed column of Tamarind Seed Powder. The effect of various parameters like flow rate, initial concentration of dye, bed height, and pH were exploited in this study. The Thomas, Yoon–Nelson, Bed Depth Service Time (BDST), and Adams and Bohart model were analysed to evaluate the column adsorption performance. The adsorption capacity, rate constant and correlation coefficient associated to each model for column adsorption was calculated and mentioned. The adsorption capacity increases with increasing initial dye concentration and bed height and decreasing flow rate. The maximum adsorption capacity related to Adams and Bohart model was found to be 978.5 mg/g at initial concentration of 50 ppm at constant flow rate of 15 mL/min, bed height of 15 cm, and pH 7.

Le but de cette étude était d'explorer l'efficacité et la faisabilité de l'Acid Yellow 17 adsorption sur colonne à lit fixe de Tamarind Seed Powder. L'effet de différents paramètres comme le débit, la concentration initiale de colorant, la hauteur du lit et le pH ont été exploitées dans cette étude. Le Thomas, Yoon‐Nelson, BDST et Adams et le modèle Bohart ont été analysées pour évaluer les performances d'adsorption colonne. La capacité d'adsorption, constante de vitesse et coefficient de corrélation associé à chaque modèle de la colonne d'adsorption a été calculé et mentionné. Les augmentations de capacité d'adsorption avec une concentration croissante de colorant initial et un lit en hauteur et le débit diminue. La capacité maximale d'adsorption liées au modèle Adams et Bohart a été trouvé à 978,5 mg/g à la concentration initiale de 50 ppm à débit constant de 15 ml/min, la hauteur du lit de 15 cm et un pH de 7.
Coenzyme Q10 Terclatrate and Creatine in Chronic Heart Failure: A Randomized, Placebo‐Controlled, Double‐Blind Study
Authors: Fumagalli Stefano , Fattirolli Francesco , Guarducci Lorenzo , Cellai Tommaso , Baldasseroni Samuele , Tarantini Francesca , Di Bari Mauro , Masotti Giulio , Marchionni Niccolò
Published: April 2011

Background:

Studies have suggested that micronutrient deficiency has some role in the progression of chronic heart failure (CHF).

Hypothesis:

Oral supplementation with coenzyme Q10 (CoQ10) and creatine may reduce mitochondrial dysfunction that contributes to impaired physical performance in CHF.

Methods:

We conducted a randomized, double‐blind, placebo‐controlled trial to determine the effect of a mixture of water‐soluble CoQ10 (CoQ10 terclatrate; Q‐ter) and creatine on exercise tolerance and health‐related quality of life. Exercise tolerance was measured as total work capacity (kg·m) and peak oxygen consumption (VO2, mL/min/kg), both from a cardiopulmonary exercise test. Health‐related quality of life was measured by the Sickness Impact Profile (SIP) in CHF secondary to left ventricular systolic dysfunction (left ventricular ejection fraction ≤ 35%). After baseline assessment, 67 patients with stable CHF were randomized to receive Q‐ter 320 mg + creatine 340 mg (n = 35) or placebo (n = 32) once daily for 8 weeks.

Results:

At multivariate analysis, 8‐week peak VO2 was significantly higher in the active treatment group than in the placebo group (+1.8 ± 0.9 mL/min/kg, 95% CI: 0.1–3.6, P < 0.05). No untoward effects occurred in either group.

Conclusions:

This study suggests that oral Q‐ter and creatine, added to conventional drug therapy, exert some beneficial effect on physical performance in stable systolic CHF. Results may support the design of larger studies aimed at assessing the long‐term effects of this treatment on functional status and harder outcomes. © 2011 Wiley Periodicals, Inc.

The study was supported by an unconditional grant from Scharper Therapeutics, Milan, Italy, which had the responsibility for manufacturing the active treatment and the placebo. The authors have no other funding, financial relationships, or conflicts of interest to disclose.