bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel effects of the cyclooxygenase-2-selective inhibitor NS-398 on IL-1β-induced cyclooxygenase-2 and IL-8 expression in human ovarian granulosa cells
Authors: Ou Hui-Ling , Sun David , Peng Yen-Chun , Wu Yuh-Lin
Published: June 2016

Ovulation is a critical inflammation-like event that is central to ovarian physiology. IL-1β is an immediate early pro-inflammatory cytokine that regulates production of several other inflammatory mediators, such as cyclooxygenase 2 (COX)-2 and IL-8. NS-398 is a selective inhibitor of COX-2 bioactivity and thus this drug is able to mitigate the COX-2-mediated production of downstream prostaglandins and the subsequent inflammatory response. Here we have investigated the action of NS-398 using a human ovarian granulosa cell line, KGN, by exploring IL-1β-regulated COX-2 and IL-8 expression. First, NS-398, instead of reducing inflammation, appeared to further enhance IL-1β-mediated COX-2 and IL-8 production. Using selective inhibitors targeting various signaling molecules, MAPK and NF-κB pathways both seemed to be involved in the impact of NS-398 on IL-1β-induced COX-2 and IL-8 expression. NS-398 also promoted IL-1β-mediated NF-κB p65 nuclear translocation but had no effect on IL-1β-activated MAPK phosphorylation. Flow cytometry analysis demonstrated that NS-398, in combination with IL-1β, significantly enhanced cell cycle progression involving IL-8. Our findings demonstrate a clear pro-inflammatory function for NS-398 in the IL-1β-mediated inflammatory response of granulosa cells, at least in part, owing to its augmenting effect on the IL-1β-induced activation of NF-κB.
Morality’s Centrality to Liking, Respecting, and Understanding Others
Authors: Hartley Anselma G. , Furr R. Michael , Helzer Erik G. , Jayawickreme Eranda , Velasquez Kassidy R. , Fleeson William
Published: June 2016

We examine morality’s relationship to three distinct dimensions of social perception: liking, respecting, and knowing a person. Participants completed two independent tasks. First, they rated acquaintances’ morality, competence, and sociability, and how much they liked, respected, and knew those acquaintances. In the second task, they rated a variety of moral and competence traits on their importance to liking, respecting, and knowing a person. Several findings emerged. First, morality was the most important factor to liking, respecting, and knowing a person but relatively more important to liking and respecting than to knowing; this finding replicated across tasks. Second, certain moral traits were more important than others, especially honesty, compassion, and fairness. Third, these traits were considered important because they were seen as potentially beneficial to the social perceiver. This research reveals morality’s centrality to evaluating and understanding others.
Sudden post-traumatic sciatica caused by a thoracic spinal meningioma
Authors: Mariniello Giuseppe , Malacario Francesca , Dones Flavia , Severino Rocco , Ugga Lorenzo , Russo Camilla , Elefante Andrea , Maiuri Francesco
Published: June 2016

Spinal meningiomas usually present with slowly progressive symptoms of cord and root compression, while a sudden clinical onset is very rare. A 35-year-old previously symptom-free woman presented sudden right sciatica and weakness of her right leg following a fall with impact to her left foot. A neurological examination showed paresis of the right quadriceps, tibial and sural muscles, increased bilateral knee and ankle reflexes and positive Babinski sign. Magnetic resonance imaging (MRI) revealed the presence of a spinal T11 meningioma in the left postero-lateral compartment of the spinal canal; at this level, the spinal cord was displaced to the contralateral side with the conus in the normal position. At surgery, a meningioma with dural attachment of the left postero-lateral dural surface was removed. The intervention resulted in rapid remission of both pain and neurological deficits. Spinal meningiomas may exceptionally present with sudden pain and neurological deficits as result of tumour bleeding or post-traumatic injury of the already compressed nervous structures, both in normal patients and in those with conus displacement or tethered cord. In this case, the traumatic impact of the left foot was transmitted to the spine, resulting in stretching of the already compressed cord and of the contralateral lombosacral roots. This case suggests that low thoracic cord compression should be suspected in patients with post-traumatic radicular leg pain with normal lumbar spine MRI.
The longevity of national identity and national pride: Evidence from wider Europe
Authors: Dimitrova-Grajzl Valentina , Eastwood Jonathan , Grajzl Peter
Published: June 2016

National pride predicts a wide range of politico-economic outcomes, yet what makes individuals proud of their nation is not completely understood. We propose and test a theory that an important but thus far unexplored determinant of contemporary national pride is the longevity of national identity. To measure the longevity of national identity, we construct an index based on responses from an original expert survey designed to trace the emergence of national identity across the polities of Europe and the former Soviet Union. We find that our National Identity Longevity Index is statistically significantly positively associated with the extent of national pride. The implied effect is robust and noteworthy in magnitude. Our results suggest that contemporary national pride inter alia reflects deep, historically rooted societal conventions which take time to emerge.
Hypotensive Activity of Ethanolic Extracts of Morinda citrifolia L. Leaves and Fruit in Dexamethasone-Induced Hypertensive Rat
Authors: Wigati Dyan , Anwar Khoerul , Sudarsono  , Nugroho Agung Endro
Published: June 2016

The effect of ethanolic extract of Morinda citrifolia leaves and fruit on blood pressure in dexamethasone-induced hypertension rat was evaluated. Total phenolic content of Morinda citrifolia leaves ethanolic extract (MCLEE) and Morinda citrifolia leaves ethanolic extract (MCFEE) was 1.789 ± 0.116 and 1.677 ± 0.051 mg of gallic acid equivalents per gram sample, respectively. Rutin level in MCLEE was 0.92 ± 0.19%, and scopoletin level in MCFEE was 0.46 ± 0.05%. MCLEE, MCFEE, and its extract combination significantly decreased the blood pressure of hypertensive rats. The combination group showed highest hypotensive activity by lowering systolic blood pressure by 16.71 ± 3.95%, diastolic blood pressure by 21.49 ± 7.90%, and mean arterial blood pressure by 19.58% ± 6.35. All extract treatments have not been able to repair or inhibit renal damage caused by dexamethasone induction.
A Case Study of Visit-Driven Preventive Care Screening Using Clinical Decision Support
Authors: Garrison Gregory M. , Traverse Chelsea R. , Fish Robert G.
Published: June 2016

Introduction:

In the traditional model of care, an annual visit was dedicated to the task of assessing and delivering preventive care. With the move away from annual physicals, primary care physicians are addressing preventive services at every clinic visit often aided by electronic clinical decision support (CDS) systems.

Methods:

We conducted a case study of a visit-driven CDS system in use at a primary care clinic. Steady-state performance was assessed via control charts of quality metrics, data regarding completion of recommendations, and an analysis of screening intervals achieved with patient visits.

Results:

Under this visit-driven CDS system, quality metric performance was poor and declining. Almost half of the patients were not screened (46.5%), and the other half were overscreened the majority of the time (83.3%). Recommended preventive services were ordered less than half the time (42.6%), despite CDS reminders.

Discussion:

Various barriers and systematic inefficiencies combined to produce ineffective screening in this visit-driven CDS preventive service delivery system. As a result, we conclude a visit-driven system cannot produce optimal results. In order to improve performance, preventive services should be delivered separately from clinical visits, perhaps by a “preventive service ranger” (PSR) utilizing the CDS system to review each patient once annually. Under such a system, patients would receive preventive services in an organized and efficient fashion, potentially leading to better continuity, higher quality metrics that are mathematically predictable, and improved satisfaction.
Does Economic Freedom Influence Major Health Indicators in India? Cross-state Panel Estimation Results
Authors: Razvi Saleema , Chakraborty Debashis
Published: June 2016

It is widely acknowledged that inadequacies in public sector health systems can only be overcome by substantial structural and institutional reforms. In India, the need for reforms in the health sector has been highlighted and stressed upon in recent period. While there is a growing belief that public and private sectors in health can potentially gain from one another, there is also recognition that, given their respective strengths and weaknesses, neither the public sector nor the private sector alone can operate in the best interest of the health system. The current study attempts to analyse the impact of enabling environments measured by the economic freedom index in 20 Indian states on select healthcare outcomes, through a panel data model. The empirical results confirm that rise in economic freedom lowers maternal mortality and infant mortality, as the resulting conducive environment enables greater private sector participation. However, the crucial role to be played by the public sector is also underlined in no uncertain terms. The obtained results strongly indicate that the health scenario in India can improve only through closer co-ordination between the public and the private sectors.
Making Sense – With Ruth Manorama, A Dalit Feminist Activist
Authors: Pathak Dev N.
Published: June 2016

The idea of Dalit summons critical revisiting in the contemporary political milieu in India. This could be a hermeneutically creative response to the onslaughts (by old as well as new worshippers of the iconic idols) on Dalits, their ideologies, epistemologies, politics and culture. To enhance the scope of Dalit politics it is imperative to make it more inclusive without compromising on the fundamental commitments. The conversation with one of the renowned Dalit-feminist activists Ruth Manorama is a pertinent occasion for raising some of the difficult questions related to Dalit thoughts and praxis, the status of Dalit women, the need to revisit Ambedkarite radicalism, and the possibility of the Dalit culture of resistance and progress. This conversation is, however, not aimed at a conclusive understanding. It seeks to spill the beans, ferret out bone(s) of contention and spread the seeds of thought (epistemes) for gradual germination. In a nutshell, the conversation is reflective of the intersections of the academic interests of Dev Pathak and an activist’s interests of Ruth Manorama. The intersection, divergent and harmonious, is a testimonial for the validity of the conversation.
Detection and sequence/structure mapping of biophysical constraints to protein variation in saturated mutational libraries and protein sequence alignments with a dedicated server
Authors: Abriata Luciano A. , Bovigny Christophe , Dal Peraro Matteo
Published: June 2016

Background

Protein variability can now be studied by measuring high-resolution tolerance-to-substitution maps and fitness landscapes in saturated mutational libraries. But these rich and expensive datasets are typically interpreted coarsely, restricting detailed analyses to positions of extremely high or low variability or dubbed important beforehand based on existing knowledge about active sites, interaction surfaces, (de)stabilizing mutations, etc.

Results

Our new webserver PsychoProt (freely available without registration at http://psychoprot.epfl.ch or at http://lucianoabriata.altervista.org/psychoprot/index.html) helps to detect, quantify, and sequence/structure map the biophysical and biochemical traits that shape amino acid preferences throughout a protein as determined by deep-sequencing of saturated mutational libraries or from large alignments of naturally occurring variants.

Discussion

We exemplify how PsychoProt helps to (i) unveil protein structure-function relationships from experiments and from alignments that are consistent with structures according to coevolution analysis, (ii) recall global information about structural and functional features and identify hitherto unknown constraints to variation in alignments, and (iii) point at different sources of variation among related experimental datasets or between experimental and alignment-based data. Remarkably, metabolic costs of the amino acids pose strong constraints to variability at protein surfaces in nature but not in the laboratory. This and other differences call for caution when extrapolating results from in vitro experiments to natural scenarios in, for example, studies of protein evolution.

Conclusion

We show through examples how PsychoProt can be a useful tool for the broad communities of structural biology and molecular evolution, particularly for studies about protein modeling, evolution and design.
Neuregulin-1 signaling is essential for nerve-dependent axolotl limb regeneration
Authors: Farkas Johanna E. , Freitas Polina D. , Bryant Donald M. , Whited Jessica L. , Monaghan James R.
Published: June 2016

The Mexican axolotl (Ambystoma mexicanum) is capable of fully regenerating amputated limbs, but denervation of the limb inhibits the formation of the post-injury proliferative mass called the blastema. The molecular basis behind this phenomenon remains poorly understood, but previous studies have suggested that nerves support regeneration via the secretion of essential growth-promoting factors. An essential nerve-derived factor must be found in the blastema, capable of rescuing regeneration in denervated limbs, and its inhibition must prevent regeneration. Here, we show that the neuronally secreted protein Neuregulin-1 (NRG1) fulfills all these criteria in the axolotl. Immunohistochemistry and in situ hybridization of NRG1 and its active receptor ErbB2 revealed that they are expressed in regenerating blastemas but lost upon denervation. NRG1 was localized to the wound epithelium prior to blastema formation and was later strongly expressed in proliferating blastemal cells. Supplementation by implantation of NRG1-soaked beads rescued regeneration to digits in denervated limbs, and pharmacological inhibition of NRG1 signaling reduced cell proliferation, blocked blastema formation and induced aberrant collagen deposition in fully innervated limbs. Taken together, our results show that nerve-dependent NRG1/ErbB2 signaling promotes blastemal proliferation in the regenerating limb and may play an essential role in blastema formation, thus providing insight into the longstanding question of why nerves are required for axolotl limb regeneration.
LGN plays distinct roles in oral epithelial stratification, filiform papilla morphogenesis and hair follicle development
Authors: Byrd Kevin M. , Lough Kendall J. , Patel Jeet H. , Descovich Carlos Patiño , Curtis T. Anthony , Williams Scott E.
Published: June 2016

Oral epithelia protect against constant challenges by bacteria, viruses, toxins and injury while also contributing to the formation of ectodermal appendages such as teeth, salivary glands and lingual papillae. Despite increasing evidence that differentiation pathway genes are frequently mutated in oral cancers, comparatively little is known about the mechanisms that regulate normal oral epithelial development. Here, we characterize oral epithelial stratification and describe multiple distinct functions for the mitotic spindle orientation gene LGN (Gpsm2) in promoting differentiation and tissue patterning in the mouse oral cavity. Similar to its function in epidermis, apically localized LGN directs perpendicular divisions that promote stratification of the palatal, buccogingival and ventral tongue epithelia. Surprisingly, however, in dorsal tongue LGN is predominantly localized basally, circumferentially or bilaterally and promotes planar divisions. Loss of LGN disrupts the organization and morphogenesis of filiform papillae but appears to be dispensable for embryonic hair follicle development. Thus, LGN has crucial tissue-specific functions in patterning surface ectoderm and its appendages by controlling division orientation.
Staphylococcus aureus recruits Cdc42GAP through recycling endosomes and the exocyst to invade human endothelial cells
Authors: Rauch Liane , Hennings Kirsten , Trasak Claudia , Röder Anja , Schröder Barbara , Koch-Nolte Friedrich , Rivera-Molina Felix , Toomre Derek , Aepfelbacher Martin
Published: June 2016

Activation and invasion of the vascular endothelium by Staphylococcus aureus is a major cause of sepsis and endocarditis. For endothelial cell invasion, S. aureus triggers actin polymerization through Cdc42, N-WASp (also known as WASL) and the Arp2/3 complex to assemble a phagocytic cup-like structure. Here, we show that after stimulating actin polymerization staphylococci recruit Cdc42GAP (also known as ARHGAP1) which deactivates Cdc42 and terminates actin polymerization in the phagocytic cups. Cdc42GAP is delivered to the invading bacteria on recycling endocytic vesicles in concert with the exocyst complex. When Cdc42GAP recruitment by staphylococci was prevented by blocking recycling endocytic vesicles or the exocyst complex, or when Cdc42 was constitutively activated, phagocytic cup closure was impaired and endothelial cell invasion was inhibited. Thus, to complete invasion of the endothelium, staphylococci reorient recycling endocytic vesicles to recruit Cdc42GAP, which terminates Cdc42-induced actin polymerization in phagocytic cups. Analogous mechanisms might govern other Cdc42-dependent cell functions.
SIRT2 inactivation reveals a subset of hyperacetylated perinuclear microtubules inaccessible to HDAC6
Authors: Skoge Renate Hvidsten , Ziegler Mathias
Published: June 2016

Deacetylation of α-tubulin at lysine 40 is catalyzed by two enzymes, the NAD-dependent deacetylase SIRT2 and the NAD-independent deacetylase HDAC6, in apparently redundant reactions. In the present study, we tested whether these two enzymes might have distinguishable preferences for the deacetylation of different microtubule structures. Using various agents, we induced tubulin hyperacetylation and analyzed the ensuing formation of distinct microtubule structures. HDAC6 inhibition led to general hyperacetylation of the microtubule network throughout the cell, whereas hyperacetylation induced by SIRT2 inactivation was limited to perinuclear microtubules. Hyperacetylation of these perinuclear microtubules was undiminished following HDAC6 overexpression, whereas reactivation of SIRT2 restored the basal acetylation level and a normal microtubule network. By contrast, SIRT2 and HDAC6 acted similarly on the morphologically different, hyperacetylated microtubule structures induced by taxol, MAP2c overexpression or hyperosmotic stress. These results indicate overlapping and distinct functions of HDAC6 and SIRT2. We propose that the differential activity of the two deacetylases, which target the same acetylated lysine residue, might be related to the recognition of specific structural contexts.
Thyroid hormones correlate with field metabolic rate in ponies,Equus ferus caballus
Authors: Brinkmann Lea , Gerken Martina , Hambly Catherine , Speakman John R. , Riek Alexander
Published: June 2016

During winter free living herbivores are often exposed to reduced energy supply at the same time that energy needs for thermoregulation increase. Several wild herbivores as well as robust horse breeds reduce their metabolism during times of low ambient temperature and food shortage. Thyroid hormones (TH) affect metabolic intensity and a positive effect of TH on basal metabolic rate (BMR) has been demonstrated in mammals and birds. As BMR and field metabolic rate (FMR) are often assumed to be intrinsically linked, TH may represent a reliable indicator for FMR. To test this hypothesis, ten Shetland pony mares were kept under semi-extensive central European conditions. During the winter month one group was fed 60% and one group 100% of their maintenance energy requirements. We measured FMR, locomotor activity, resting heart rate and TH levels in summer and winter. FMR, locomotor activity, resting heart rate and total T3 concentrations decreased substantially in winter compared to summer, whereas total T4 increased. Feed restriction led to a reduced FMR and resting heart rate, while TH and locomotor activity were not affected. Across both seasons FMR, resting heart and locomotor activity were positively correlated with total T3 but negatively and more weakly related with total T4.
Eukaryote-specific rRNA expansion segments function in ribosome biogenesis
Authors: Ramesh Madhumitha , Woolford John L.
Published: June 2016

The secondary structure of ribosomal RNA (rRNA) is largely conserved across all kingdoms of life. However, eukaryotes have evolved extra blocks of rRNA sequences, relative to those of prokaryotes, called expansion segments (ES). A thorough characterization of the potential roles of ES remains to be done, possibly because of limitations in the availability of robust systems to study rRNA mutants. We sought to systematically investigate the potential functions, if any, of the ES in 25S rRNA of Saccharomyces cerevisiae by deletion mutagenesis. We deleted 14 of the 16 different eukaryote-specific ES in yeast 25S rRNA individually and assayed their phenotypes. Our results show that all but two of the ES tested are necessary for optimal growth and are required for production of 25S rRNA, suggesting that ES play roles in ribosome biogenesis. Further, we classified expansion segments into groups that participate in early nucleolar, middle, and late nucleoplasmic steps of ribosome biogenesis, by assaying their pre-rRNA processing phenotypes. This study is the first of its kind to systematically identify the functions of eukaryote-specific expansion segments by showing that they play roles in specific steps of ribosome biogenesis. The catalog of phenotypes we identified, combined with previous investigations of the roles ribosomal proteins in large subunit biogenesis, leads us to infer that assembling ribosomes are composed of distinct RNA and protein structural neighborhood clusters that participate in specific steps of ribosome biogenesis.
Διερεύνηση των απόψεων φοιτητών του ΜΠΣ ‘Σπουδές στην Εκπαίδευση’ για την εξ αποστάσεως εξατομικευμένη μάθηση του ΕΑΠ - Μία μελέτη περίπτωσης
Authors: Τζώτζου Μαρία , Μπιγιλάκη Νίτσα
Published: June 2016

Η ΑεξΑΕ διαφέρει από τη συμβατική στο ότι δεν βασίζεται στην ‘πρόσωπο με πρόσωπο’ μετάδοση της γνώσης, αλλά στην ‘εξατομίκευση’ της μάθησης, κυρίως μέσα από την κατ’ ιδίαν μελέτη εκπαιδευτικού υλικού που προσφέρει τοεκπαιδευτικό ίδρυμα. Οι ενήλικοι σπουδαστές εμπλέκονται σε μια διαδικασία ‘εξατομικευμένης μάθησης’ ή αλλιώς ‘αυτομάθησης’, βάσει της οποίας αναγνωρίζονται και ικανοποιούνται οι ατομικές διαφορές, ανάγκες και προσδοκίες τους. Η μάθηση βιώνεται ως ‘ατομική υπόθεση’ μέσα από την εξατομίκευση της μαθησιακής διεργασίας που προϋποθέτει και συνεπάγεται την ενίσχυση της ενηλικιότητας και την ανεξαρτησία του ενηλίκου σπουδαστή, ο οποίος αυτενεργεί, αυτοεκφράζεται, αυτοκαθορίζεται, αυτοελέγχεται και αυτοεξελίσσεται. Με την παρούσα εργασία-μελέτη περίπτωσης διερευνήθηκαν οι απόψεις σπουδαστών του ΜΠΣ ‘Σπουδές στην Εκπαίδευση’ για την εξ αποστάσεως εξατομικευμένη μάθηση του ΕΑΠ. Για τις ανάγκες της έρευνας επιλέχθηκαν οι έξι βασικότερες συνιστώσες εφαρμογής της εξατομικευμένης μάθησης στο ΕΑΠ: α. το εκπαιδευτικό υλικό, β. η διαπροσωπική επικοινωνία, γ. η υποστήριξη των φοιτητών, δ. ο ρόλος του Καθηγητή-Συμβούλου (ΚΣ), ε. η χρήση των νέων τεχνολογιών και στ. η παροχή υπηρεσιών (μητρώου και βιβλιοθήκης), θεωρώντας ότι πρόκειται για μετρήσιμες συνιστώσες που μπορούν να αξιοποιηθούν στην πράξη προκειμένου να ενισχύσουν την αυτοαντίληψη, τον αυτοκαθορισμό και την αυτοεκτίμηση των σπουδαστών στις εξ αποστάσεως εξατομικευμένες σπουδές τους. Για το λόγο αυτό, δόθηκε έμφαση στην καταγραφή των πλεονεκτημάτων και κυρίως των μειονεκτημάτων εφαρμογής της εξατομικευμένης μάθησης και διατυπώθηκαν προτάσεις για την ενίσχυση των πλεονεκτημάτων και για τον περιορισμό των προβλημάτων που αντιμετωπίζουν οι ενήλικοι σπουδαστές του ΕΑΠ.
Teleconference in support of distance learning: Views of educators
Authors: Panagiotakopoulos Christos , Tsiatsos T. , Lionarakis Antonis , Tzanakos Nikolaos
Published: June 2016

In this study we recorded the views of the educators that use teleconference as an educational medium to support distance learning. The data were collected using the semi-structured interview and the results showed that teleconferencing could be a strong complementary tool to support flexible learning as well as distance education, by enhancing the interaction among learners. All the interviewees consider teleconference as a "helpful assistant" in the educational process and suggested that the educators should be well prepared before the tele-lecture, as well as prepare and guide the learners in order to conduct a smooth teleconferencing session. From the interviews, several advantages and disadvantages of the teleconference’s use as an educational tool emerged. The main advantages consist of the independence of spaceand time while conducting learning sessions, the easy access to and sharing of educational content, the interaction between educator and learners as well as among the learners and the reduced transportations along with time saving. On the other hand, some important disadvantages refer to the participants being unfamiliar with technology, lack of technological support, limited network resources causing disconnections and adding stress to participants, the uncertainty of the participantsregarding the effectiveness of teleconference in education and the lack of face-to-face communication.
Η έρευνα για την ΕξΑΕ με τη χρήση των ΤΠΕ (e-learning) στο Ελληνικό Τυπικό Εκπαιδευτικό Σύστημα. Ανασκόπηση και προοπτικές για την Πρωτοβάθμια, Δευτεροβάθμια και Τριτοβάθμια Εκπαίδευση.
Authors: Αναστασιάδης Πάνος
Published: June 2016

Η ραγδαία ανάπτυξη των ΤΠΕ συμβάλλει καθοριστικά στη διαμόρφωση ενός νέου περιβάλλοντος στο χώρο της Εξ Αποστάσεως Εκπαίδευσης (ΕξΑΕ) τόσο διεθνώς όσο και στην Ελλάδα.  Η παρούσα εργασία έχει ως σκοπό να διερευνήσει  τις τάσεις που διαμορφώνονται για την ΕξΑΕ με την χρήση των ΤΠΕ (e-learning) στην ελληνική εκπαιδευτική πραγματικότητα. Η ανασκόπηση της σχετικής βιβλιογραφίας  από τη δεκαετία του 1990 έως και τις μέρες μας καλύπτει και τις τρεις βαθμίδες του «Τυπικού Εκπαιδευτικού Συστήματος», την Πρωτοβάθμια, τη Δευτεροβάθμια και την Τριτοβάθμια  εκπαίδευση.
Η εξ αποστάσεως ομαδοσυνεργατική εκπαίδευση στο πλαίσιο ψηφιακών κοινοτήτων μάθησης ως μέσο ανάπτυξης κοινωνικών δεξιοτήτων στην περιβαλλοντική εκπαίδευση
Authors: Αποστόλου Μαριάννα , Αντωνίου Παναγιώτης , Παπαστεργίου Μαρίνα
Published: June 2016

Τα σχέδια εργασίας θεωρούνται για την Περιβαλλοντική Εκπαίδευση (ΠΕ) ως η καταλληλότερη διδακτική μεθοδολογία (Βασάλα, 1994). Τα σχέδια εργασίας προϋποθέτουν ομαδοσυνεργατική μάθηση και ομαδικές εργασίες και έχουν ως σκοπό την ανάπτυξη των κοινωνικο-γνωστικών δεξιοτήτων των μαθητών/ριών (Μιχαηλίδης, 2003). Οι δεξιότητες αυτές αποτελούν γέφυρα ανάμεσα στη σχολική γνώση και την ενήλικη ζωή (Ματσαγγούρας, 2003). Σχέδια εργασίας (Frey, 1998) μπορούν να υλοποιηθούν από απόσταση μέσω του Διαδικτύου, αν αξιοποιηθούν οι δυνατότητες που παρέχουν οι Ψηφιακές Κοινότητες Μάθησης (ΨΚΜ). Στόχος της παρούσας έρευνας ήταν να αξιολογηθεί η επίδραση που ενδεχομένως είχε στις κοινωνικές δεξιότητες των μαθητών/ριών η συμμετοχή τους σε ΨΚΜ για την εκπόνηση ενός σχεδίου εργασίας στο πλαίσιο ενός προγράμματος ΠΕ. Είκοσι-επτά μαθητές/ριες της Α΄ τάξης Γυμνασίου ολοκλήρωσαν το σχέδιο εργασίας: «Δασικό οικοσύστημα: ωφέλειες - απειλές» χρησιμοποιώντας ως περιβάλλον αλληλεπίδρασης ΨΚΜ που αναπτυχθήκαν μέσω της διαδικτυακής υπηρεσίας Yahoo Groups. Οι κοινωνικές δεξιότητες των μαθητών/ριών  αξιολογήθηκαν με το ερωτηματολόγιο των Κοινωνικών Δεξιοτήτων για Μαθητές (SSQ-PU) (Spence, 1995) πριν και μετά τη συμμετοχή των μαθητών/ριών στις ΨΚΜ. Από την ανάλυση των δεδομένων προέκυψε ότι η βασιζόμενη σε σχέδια εργασίας εξ αποστάσεως ομαδοσυνεργατική μάθηση που έλαβε χώρα στις ΨΚΜ ενίσχυσε σημαντικά τις κοινωνικές δεξιότητες των μαθητών/ριών.
Η Ανοικτή και εξ αποστάσεως εκπαίδευση σε άτομα κοινωνικά αποκλεισμένα, όπως οι κρατούμενοι. Μελέτη περίπτωσης: η εκπαίδευση των κρατουμένων στο Ανοικτό Πανεπιστήμιο της Μ. Βρετανίας
Authors: Λιναρδάτου Χαριτίνη , Mανούσου Ευαγγελία
Published: June 2016

Ο κοινωνικός αποκλεισμός αποτελεί ένα οξύ ζήτημα για τις σύγχρονες παγκοσμιοποιημένες κοινωνίες καθώς η αντιμετώπιση του σχετίζεται άμεσα με την καταπολέμηση της φτώχειας και τη δυνατότητα ενσωμάτωσης (integration) ορισμένων κοινωνικών ομάδων στην αγορά εργασίας. Στο άρθρο αυτό θα παρουσιαστεί και θα συζητηθεί ο ρόλος της Ανοικτής και εξ Αποστάσεως Εκπαίδευσης σε άτομα κοινωνικά αποκλεισμένα όπως είναι οι κρατούμενοι. Πρόκειται για μια βιβλιογραφική έρευνα που εστιάστηκε στα χαρακτηριστικά της εξ αποστάσεως εκπαίδευσης που παρέχεται σε κρατούμενους σε Ευρωπαϊκές χώρες (Αγγλία, Γαλλία, Σκανδιναβικές χώρες). Πιο συγκεκριμένα παρουσιάζεται πως οριοθετείται η εξ αποστάσεως εκπαίδευση σε κρατούμενους σύμφωνα με τους Ευρωπαϊκούς Σωφρονιστικούς Κανόνες και αναδεικνύεται η συμβολή των Ανοικτών Πανεπιστημίων  στη  πρόσβαση των κρατουμένων στην τριτοβάθμια εξ αποστάσεως εκπαίδευση. Ειδικότερα, μελετώνται και αναλύονται οι παράγοντες που προσδιορίζουν την εκπαίδευση των κρατουμένων στο Ανοικτό Πανεπιστήμιο της Μ. Βρετανίας.
Πώς οι νέες Διαδικτυακές Τεχνολογίες διαμορφώνουν την Ανοικτή και εξ αποστάσεως Εκπαίδευση στο άμεσο μέλλον
Authors: Γκελαμέρης Δημήτρης Β.
Published: June 2016

Η εργασία αυτή επιχειρεί να συνεισφέρει προς την κατεύθυνση αναγνώρισης των νέων χαρακτηριστικών που αποκτά η Ανοιχτή και εξ αποστάσεως εκπαίδευση (ΑεξΑΕ) υπό την επίδραση των Τεχνολογιών της Πληροφορίας και των Επικοινωνιών (ΤΠΕ)Αρκετά πανεπιστήμια χρησιμοποιούν τη Συνδυαστική ηλεκτρονική μάθηση-(ΣΗΜ), δηλαδή διδακτικά μοντέλα που συνδυάζουν ή αναμειγνύουν μεθόδους σύγχρονης και ασύγχρονης μάθησης με τη χρήση της διαδικτυακής τεχνολογίας, με την υποστήριξη Συστημάτων Διαχείρισης Εκπαίδευσης (IMS), όπως τα διαχειριστικά συστήματα μάθησης (LMS) και τα συστήματα διαχείρισης εκπαιδευτικού περιεχομένου (LCMS) δημιουργώντας ένα καινοτόμο εκπαιδευτικό περιβάλλον, που υπόσχεται να αποκαταστήσει την αμφίδρομη επικοινωνία μεταξύ διδασκόντων και διδασκομένων και να αυξήσει τη διαλογικότητα του φοιτητή με το εκπαιδευτικό περιβάλλον. Η αλματώδης εξέλιξη των νέων Τεχνολογιών στην πρώτη δεκαετία του 21ου αιώνα δημιουργεί νέα δεδομένα στον χώρο της AΕξΑΕ, μεταβάλλοντας σημαντικά το περιβάλλον μάθησης, επικοινωνίας και αλληλεπίδρασης με την εισαγωγή των Ανοιχτών Εκπαιδευτικών Πόρων(OERs),των Μαζικών Ανοικτών Διαδικτυακών Σειρών Μαθημάτων (MOOCs) των Learning Analytics-LA και των Educational Data Mining-EDM κυρίως στην ανώτατη εκπαίδευση.
Η χρήση wiki ως εργαλείο υλοποίησης Διαδικτυακής Κοινότητας Πρακτικής
Authors: Θεοφανέλλης Τιμολέων , Καράκιζα Τσαμπίκα , Φεσάκης Γεώργιος
Published: June 2016

Στην εργασία αυτή παρουσιάζεται η αξιολόγηση μιας διαδικτυακής δομής ανταλλαγής με στόχο την ανάπτυξη της συνεργασίας των καθηγητών της πληροφορικής που διδάσκουν στο Γυμνάσιο. Είναι φυσικό οι άνθρωποι που διδάσκουν το ίδιο αντικείμενο, να αντιμετωπίζουν κοινά καθημερινά προβλήματα και προκλήσεις. Πολύ συχνά εντοπίζουν αξιόλογες λύσεις, καινοτομούν και δημιουργούν υψηλής ποιότητας υλικό. Στη βάση αυτή προτείνεται ο διαμοιρασμός αυτών των ιδεών, πρακτικών και προτάσεων ανάμεσα στους συναδέλφους που βιώνουν καθημερινά τις ίδιες αναγκαιότητες. Τέτοια δυνατότητα διαμοιρασμού δίνουν οι ΤΠΕ και πιο συγκεκριμένα κάποιες υπηρεσίες του web 2.0. Στην παρούσα μελέτη αξιολογείται η χρήση της υπηρεσίας wiki, όπως πραγματοποιήθηκε με ομάδα εκπαιδευτικών πληροφορικής που διδάσκουν στο Γυμνάσιο. Η δημιουργία και η λειτουργία του wiki υλοποιήθηκε από τους Σχολικούς Συμβούλους Πληροφορικής Βορείου και Νοτίου Αιγαίου.
Οι σπουδές για το χορό στο Ελληνικό Ανοικτό Πανεπιστήμιο και ο ρόλος της «Σχεδιασμένης Συμπεριφοράς» στη συμμετοχή των φοιτητών σε οργανωμένες μεταπτυχιακές σπουδές με την εξ αποστάσεως μέθοδο διδασκαλίας
Authors: Γουλιμάρης Δημήτρης , Μπεμπέτσος Ευάγγελος , Φιλίππου Φίλιππος
Published: June 2016

Υπάρχουν πολλοί παράγοντες που μπορεί να παίξουν ρόλο στην πρόβλεψηορισμένων συμπεριφορών όπως είναι η συμμετοχή σ’ ένα μεταπτυχιακό πρόγραμμα σπουδών για το χορό. Η αξιολόγηση των παραμέτρων της εκπαιδευτικής διαδικασίας στα πλαίσια του ΕΑΠ αποτελεί αντικείμενο μελέτης ολοένα και περισσότερων ερευνών. Σκοπός της εργασίας είναι να διαπιστωθεί αν η συμμετοχή των φοιτητών σε οργανωμένες μεταπτυχιακές σπουδές για το χορό με την εξ αποστάσεως μέθοδο διδασκαλίας, επηρεάζεται από την αξιολόγηση τους για την θεματική ενότητα (Θ.Ε.)που αφορά το χορό στα πλαίσια του προπτυχιακού προγράμματος σπουδών στο ΕΑΠ. Παράλληλα διερευνήθηκε η αξιολόγηση των σπουδών τους και τωνπαραγόντων που επηρεάζουν την μελλοντική συμμετοχή τους στο μεταπτυχιακό πρόγραμμα. Το δείγμα της έρευνας είναι 151 φοιτητές/τριες του ΕΑΠ που παρακολούθησαν την Θ.Ε. «Τέχνες ΙΙ: Επισκόπηση Ελληνικής Μουσικής και Χορού» (ΕΛΠ 40). Χρησιμοποιήθηκε το ερωτηματολόγιο της «Σχεδιασμένης Συμπεριφοράς» και το ερωτηματολόγιο «Αξιολόγησης της Θ.Ε. ΕΛΠ 40». Από τα αποτελέσματα προκύπτει ότι η θετική προδιάθεση, η σιγουριά και η ικανότητα που νιώθουν οι φοιτητές σε μικρότερο βαθμό διαμορφώνουν μια θετική τάση για τις μεταπτυχιακές σπουδές για το χορό με την εξ αποστάσεως μέθοδο εκπαίδευσης. Ωστόσο υπάρχουν σημαντικά περιθώρια βελτίωσης των παραγόντων που επηρεάζουν την συμπεριφορά των φοιτητών. Παράλληλα οι φοιτητές αξιολόγησαν πολύ υψηλά τους Συμβούλους Καθηγητές ενώ την χαμηλότερη αξιολόγηση έδωσανστις «Υπηρεσίες του ΕΑΠ». Ακόμη καταγράφηκε μια μικρή αλλά υπαρκτή τάση συσχέτισης των παραγόντων που προβλέπουν την συμμετοχή των φοιτητών σε μεταπτυχιακές σπουδές και της αξιολόγησης της ΘΕ. Ενδιαφέρον είναι ότι η αξιολόγηση των Συμβούλων Καθηγητών δεν σχετίστηκε καθόλου με τις στάσεις και τις προθέσεις των φοιτητών. Τέλος, σχετικά υψηλή συσχέτιση παρουσιάστηκε μεταξύ των παραγόντων αξιολόγησης της Θ.Ε.
Συνέντευξη με τον Don Olcott Jr.
Authors: Ιωακειμίδου Βασιλική (Σύλβη)
Published: June 2016

Συνέντευξη με τον Don Olcott Jr.
Συνέντευξη με τον Don Olcott
Authors: Παπαδημητρίου Σοφία
Published: June 2016

Dr. Don Olcott, Jr., FRSA: President, HJ Global Associates Professor of Leadership and ODL (Adjunct) University of Maryland University College (UMUC)
Συνολικό Τεύχος
Authors: Τεύχος Συνολικό
Published: June 2016

Open Education - The Journal for Open and Distance Education and Educational TechnologyVolume 5, Number 1, 2009 ©Open Education ISSN: 1791-9312
Open Education Vol.4, Num.1, 2008
Authors: Τεύχος Συνολικό
Published: June 2016

Συνολικό τεύχος
Συνολικό Τεύχος
Authors: Issue Full
Published: June 2016

Το Συνολικό Τεύχος του Περιοδικού
Συνολικό Τεύχος
Authors: Τεύχος Συνολικό
Published: June 2016

Το Συνολικό Τεύχος
Editorial
Authors: Λιοναράκης Αντώνης
Published: June 2016

Editorial v9 issue1
Κοινωνική έρευνα και κρατική πολιτική
Authors: Κονιαβίτης Θωμάς
Published: June 2016

Τι γίνεται με μια επιστήμη που το αντικείμενο της αλλάζει; Τι έγινε με την κοινωνιολογία και την κοινωνική έρευνα τη δεύτερη περίοδο του 20ου αιώνα, τη 'χρυσή εποχή' (1947-1973), σύμφωνα με την ορολογία του Eric Hobsbawm (2004), και τι ακολούθησε στη συνέχεια κατά την τρίτη περίοδο, εκείνη 'την εποχή των κρίσεων' με τις οποίες τέλειωσε ο 'σύντομος' αυτός αιώνας στις αρχές του 1990, όταν κατέρρευσαν τα καθεστώτα της ανατολικής Ευρώπης; Στο άρθρο αυτό υποστηρίζεται καταρχάς ότι οι τροποποιήσεις και οι εξειδικεύσεις που συντελέστηκαν στην κοινωνιολογία και στην κοινωνική έρευνα αυτό το χρονικό διάστημα (των δύο εποχών) βρίσκονται σε συνάρτηση με την εμφάνιση, τη γενικευμένη επικράτηση και την κρίση του κράτους ευημερίας· πιο συγκεκριμένα, με την αλλαγή του ρόλου του κράτους. Καθοριστικό για τις εξελίξεις στην κοινωνική έρευνα είναι το πρόβλημα που αναδεικνύεται από τις σχέσεις μεταξύ της 'κρατικής πολιτικής για την κοινωνική έρευνα' ['science policy', εφεξής: 'πολιτυχή για την επιστήμη'] και της 'κοινωνικής έρευνας που προσπαθεί να συνδράμει με επιστημονική γνώση την κρατική πολιτική' ['policy sciences', εφεξής 'έρευνα για την πολιτική']. Είναι ίσως η μοναδική περίοδος στην ιστορΐα της κοινωνιολογίας και της κοινωνικής έρευνας που οι σχέσεις των κοινωνικών επιστημών με την αναπαραγωγική λειτουργία του κράτους είναι τόσο άμεσες και τόσο εμφανείς. Ίσως ήταν οι αρμονικές σχέσεις μεταξύ κράτους και κοινωνικής έρευνας που συνέβαλαν ώστε οι επιπτώσεις στην κοινωνική έρευνα από την 'κρίση' του κράτους  ευημερίας και τις νεο-φιλελεόθερες πολιτικές των συντηρητικών κυβερνήσεων να είναι τόσο αρνηπκές. Υποστηρίζεται επίσης ότι, προς το τέλος της δεκαετίας του 1970 και στις αρχές εκείνης του 1980, παρατηρείται μια νέα μεθοδολογική στροφή. Στη συνέχεια, παρουσιάζονται ορισμένα βασικά 'πρότυπα εφαρμοσμένης κοινωνικής έρευνας' και το άρθρο κλείνει με τον εντοπισμό συγκεκριμένων στοιχείων που είναι δυνατόν να οδηγήσουν στην επανεξέταση βασικών παραδοχών στις οποίες θεμελιώνεται η εφαρμοσμένη κοινωνική έρευνα κατά τρόπο που αυτή να ανταποκρίνεται πλέον στις νέες συνθήκες που δημιουργούνται την περίοδο της παγκοσμιοποίησης. Το άρθρο περιορίζεται στην εμπειρική (ή αναλυτυχή) κοινωνιολογία όπως αυτή αναπτύχθηκε στις ΗΠΑ και την Ευρώπη
In memoriam: Ralf Dahrendorf
Authors: Καρκατσούλης Παναγιώτης
Published: June 2016

Δεν διατίθεται περίληψη.
Οντέτ Βαρών-Βασάρ, Η ενηλικίωση μιας γενιάς. Νέοι και νέες στην Κατοχή και στην Αντίσταση
Authors: Δρουμπούκη Αννα-Μαρία
Published: June 2016

Οντέτ Βαρών-Βασάρ, Η ενηλικίωση μιας γενιάς. Νέοι και νέες στην Κατοχή και
στην Αντίσταση, Σειρά: Ιστορία και πολιτική, εκδ. Βιβλιοπωλείου της Εστίας,
Αθήνα 2009, σελ. 556 + 8 σ. φωτογραφικό ένθετο
Ζύγκμουντ Μπάουμαν. Ρευστή αγάπη: Για την ευθραυστότητα των ανθρώπινων δεσμών
Authors: Λιότζης Ευάγγελος
Published: June 2016

Ζύγκμουντ Μπάουμαν. Ρευστή αγάπη: Tta την ευθραυστότητα των ανθρώπινων
δεσμών, Εστία, Αθήνα 2006,276 σελ.
Γιάννης Κωνσταντινίδης, Νίκος Μαραντζίδης & Τάκης Παππάς (επιμ.). Κόμματα και πολιτική στην Ελλάδα: Οι σύγχρονες εξελίξεις
Authors: Ρουσιάς Νάσος
Published: June 2016

Γιάννης Κωνσταντινίδης, Νίκος Μαραντζίδης & Τάκης Παππάς (επιμ.). Κόμματα
και πολιτική στην Ελλάδα: Οι σύγχρονες εξελίξεις, εκδόσεις Κριτική, Αθήνα
2009,336 σελ.
Recent advances in primary Sjogren's syndrome
Authors: Holdgate Nicholas , St.Clair E. Wiliam
Published: June 2016

Primary Sjögren’s syndrome, a chronic inflammatory process, is among the most commonly occurring rheumatologic diseases. The clinical hallmark of this disease is exocrine gland dysfunction, resulting predominately in dry eyes and dry mouth. However, the disease often extends beyond the exocrine glands to seriously affect other organs systems, such as the lungs, kidneys, and nervous system. Moreover, patients with primary Sjögren’s syndrome develop non-Hodgkin’s B cell lymphoma at a substantially higher rate than the general population. New research has improved our understanding of disease mechanisms, with notable advances in our knowledge about the genetic susceptibility of disease, the molecular details of the chronic inflammatory response in the salivary glands, and the complex role of the type 1 interferon pathway. The pipeline of drugs under development for the treatment of primary Sjögren’s syndrome is enriched with novel biologics and small molecular entities targeting the pathogenic process. Herein, we summarize the latest advances in elucidating the pathogenesis of primary Sjögren’s syndrome and highlight new drugs in clinical development aiming to reverse the glandular dysfunction and favorably impact the systemic features of this disease.
Routing and Staffing When Servers Are Strategic
Authors: Gopalakrishnan Ragavendran , Doroudi Sherwin , Ward Amy R. , Wierman Adam
Published: June 2016

Traditionally, research focusing on the design of routing and staffing policies for service systems has modeled servers as having fixed (possibly heterogeneous) service rates. However, service systems are generally staffed by people. Furthermore, people respond to workload incentives; that is, how hard a person works can depend both on how much work there is and how the work is divided between the people responsible for it. In a service system, the routing and staffing policies control such workload incentives; and so the rate servers work will be impacted by the system’s routing and staffing policies. This observation has consequences when modeling service system performance, and our objective in this paper is to investigate those consequences.

We do this in the context of the M/M/N queue, which is the canonical model for large service systems. First, we present a model for “strategic” servers that choose their service rate to maximize a trade-off between an “effort cost,” which captures the idea that servers exert more effort when working at a faster rate, and a “value of idleness,” which assumes that servers value having idle time. Next, we characterize the symmetric Nash equilibrium service rate under any routing policy that routes based on the server idle time (such as the longest idle server first policy). We find that the system must operate in a quality-driven regime, in which servers have idle time, for an equilibrium to exist. The implication is that to have an equilibrium solution the staffing must have a first-order term that strictly exceeds that of the common square-root staffing policy. Then, within the class of policies that admit an equilibrium, we (asymptotically) solve the problem of minimizing the total cost, when there are linear staffing costs and linear waiting costs. Finally, we end by exploring the question of whether routing policies that are based on the service rate, instead of the server idle time, can improve system performance.
Integrated Disruption Management and Flight Planning to Trade Off Delays and Fuel Burn
Authors: Marla Lavanya , Vaaben Bo , Barnhart Cynthia
Published: June 2016

In this paper we present a novel approach addressing airline delays and recovery. Airline schedule recovery involves making decisions during operations to minimize additional operating costs while getting back on schedule as quickly as possible. The mechanisms used include aircraft swaps, flight cancellations, crew swaps, reserve crews, and passenger rebookings. In this context, we introduce another mechanism, namely flight planning that enables flight speed changes. Flight planning is the process of determining flight plan(s) specifying the route of a flight, its speed, and its associated fuel burn. Our key idea in integrating flight planning and disruption management is to adjust the speeds of flights during operations, trading off flying time (and along with it, block time) and fuel burn; in combination with existing mechanisms, such as flight holds. Our goal is striking the right balance of fuel costs and passenger-related delay costs incurred by the airline. We present both exact and approximate models for integrated aircraft and passenger recovery with flight planning. From computational experiments on data provided by a European airline, we estimate that the ability of our approach to control (decrease or increase) flying time by trading off with fuel burn, as well as to hold downstream flights, results in reductions in passenger disruptions by approximately 66%–83%, accompanied by small increases in fuel burn of 0.152%–0.155% and a total cost savings of approximately 5.7%–5.9% for the airline, may be achieved compared to baseline approaches typically used in practice. We discuss the relative benefits of two mechanisms studied—specifically, flight speed changes and intentionally holding flight departures, and show significant synergies in applying these mechanisms. The results, compared with recovery without integrated flight planning, are because of increased swap possibilities during recovery, decreased numbers of flight cancellations, and fewer disruptions to passengers.
Nest density and other observations on a population of Aneuretus simoni Emery, 1893 (Formicidae, Aneuretinae) and other ants in Indikada Mukalana Forest Reserve in Sri Lanka
Authors: Dias Ratnayake K. S. , Udayakantha Warnakulasuriyage S.
Published: June 2016

The Sri Lankan Relict Ant, Aneuretus simoni Emery, survives in several wet zone and intermediate zone forests in Sri Lanka. Nests of this species and other ants were surveyed at 159 m and 291 m elevations in Indikada Mukalana Forest Reserve by laying 20 quadrats of 1 m × 1 m at two plots of each locality in December, 2015. The number of ant nests within each quadrat was recorded; then the frequency of nest occurrence out of 40 quadrats, percentage nest abundance and mean nest density of A. simoni, as well as associated ant fauna were calculated. Percentage frequency of worker ant occurrence was also investigated using pitfall traps. Eighteen genera and 21 species in Aneuretinae, Dolichoderinae, Formicinae, Myrmicinae and Ponerinae were recorded from the two methods. Nests of A. simoni were found only in the locality at 291 m altitude in the forest; 17.5 % of quadrats with an A. simoni colonies, 9.7% of nest abundance in relation to that of other ant species and 0.18 m2 ofmean nest density were observed. Nest density of A. simoni had the fourth rank among that of the other species. Frequency of occurrence of A. simoni workers in the pitfall traps at lower and upper elevations was 2% and 3%, respectively. An actualized map showing the current distribution of A. simoni is produced.
Hip arthroscopy in the setting of hip dysplasia
Authors: Yeung M. , Kowalczuk M. , Simunovic N. , Ayeni O. R.
Published: June 2016

Objective

Hip arthroscopy in the setting of hip dysplasia is controversial in the orthopaedic community, as the outcome literature has been variable and inconclusive. We hypothesise that outcomes of hip arthroscopy may be diminished in the setting of hip dysplasia, but outcomes may be acceptable in milder or borderline cases of hip dysplasia.

Methods

A systematic search was performed in duplicate for studies investigating the outcome of hip arthroscopy in the setting of hip dysplasia up to July 2015. Study parameters including sample size, definition of dysplasia, outcomes measures, and re-operation rates were obtained. Furthermore, the levels of evidence of studies were collected and quality assessment was performed.

Results

The systematic review identified 18 studies investigating hip arthroscopy in the setting of hip dysplasia, with 889 included patients. Criteria used by the studies to diagnose hip dysplasia and borderline hip dysplasia included centre edge angle in 72% of studies but the range of angles were quite variable. Although 89% of studies reported improved post-operative outcome scores in the setting of hip dysplasia, revision rates were considerable (14.1%), with 9.6% requiring conversion to total hip arthroplasty.

Conclusion

The available orthopaedic literature suggests that although improved outcomes are seen in hip arthroscopy in the setting of hip dysplasia, there is a high rate of re-operation and conversion to total hip arthroplasty. Furthermore, the criteria used to define hip dysplasia vary considerably among published studies. Cite this article: M. Yeung, M. Kowalczuk, N. Simunovic, O. R. Ayeni. Hip arthroscopy in the setting of hip dysplasia: A systematic review. Bone Joint Res 2016;5:225–231. DOI: 10.1302/2046-3758.56.2000533.