bluuebunny/crossref_metadata_2025 huggingface dataset:
Friction and Structural Responses of Ion Implanted Polyoxymethylene Copolymer (POM-C)
Authors: Rahman Md. Shahinur , Lyakhov Konstantin , Yang Jong-Keun , Uddin Muhammad Athar , Chowdhury Muhammad Sifatul Alam
Published: November 2016

Polyoxymethylene copolymer (POM-C) round block was implanted with 120 KeV ions of He to doses of 5 x 1016 and 1 x 1016 ions cm-2. It was also implanted with 120 KeV ions of Ar + He and He + Ne to dose of 1 x 1016 ions cm-2, respectively. The friction coefficient behavior of both implanted and unimplanted POM-C blocks was investigated using a ball on disk tribometer mechanism. The friction coefficient of He ion implanted POM-C block at a dose of 5 x 1016 ions cm-2 is lowest compared to all unimplanted and others ions doses implanted POM-C blocks. It also shows the moderate surface texturing (atomic rearrangement), lower surface micro-hardness and average surface roughness compared to both unimplanted and other ions doses implanted POM-C blocks due to well adjusted carbonization, cross-linking and ions-target atoms collisions, which is ascertained from SEM-EDS, Raman spectroscopic and surface profiling observations. The other ions doses implanted POM-C blocks demonstrate the higher friction coefficient and surface roughness with polymer surface deformation (crazing, cracking, pitting and gas evolution, bond breaking) due to severe chain scission, surface dose delivered atomic displacements and chemical structural degradation. It is concluded that the variation in friction coefficient behavior of POM-C block resulted from its structural response for ion beam implantation on the top surface.
Comparison of Encryption Algorithms for Multimedia
Authors: Ahamad Md. Martuza , Abdullah Md. Ibrahim
Published: November 2016

Cryptographic techniques play crucial role when users exchange information. Multimedia plays an important role in learning and sharing experiences. When multimedia contents are shared among the users, it faces security threats. Usually multimedia contents takes much space. Encryption technique should be time efficient. In this work we consider four encryption techniques: Blowfish, AES, XOR and RSA and four types of media content: text, image, audio and video. Simulation shows that AES is time efficient than others. Comparing between symmetric and asymmetric cryptography, symmetric cryptographic techniques take less time than asymmetric technique.
Feasibility Study of a Gripper with Thermally Controlled Stiffness of Compliant Jaws
Authors: Hao Guangbo , Riza Mehdi
Published: November 2016

This paper proposes a simple and compact compliant gripper, whose gripping stiffness can be thermally controlled to accommodate the actuation inaccuracy to avoid or reduce the risk of breaking objects. The principle of reducing jaw stiffness is that thermal change can cause an initial internal compressive force along each compliant beam. A prototype is fabricated with physical testing to verify the feasibility. It has been shown that when a voltage is applied, the gripping stiffness effectively reduces to accommodate more inaccuracy of actuation, which allows delicate or small-scale objects to be gripped.
The Machining of Hard Mold Steel by Ultrasonic Assisted End Milling
Authors: Tsai Ming , Chang Chia , Ho Jihng
Published: November 2016

This study describes the use of ultrasonic-assisted end milling to improve the quality of the machined surface of hard Stavax (modified AISI 420) mold steel and to reduce the amount of work involved in the final polishing process. The effects of input voltage, the stretch length and cutter holding force on the amplitude of the ultrasonic vibration used were measured. The effect of ultrasonic frequency (25 and 50 kHz) and amplitude (0, 2.20 and 3.68 μm) as well as the effect of the rake angle (6° and −6°) and the cutter helix angle (25°, 35° and 45°) on tool wear and quality of the workpiece surface finish were also investigated. It was found that the ultrasonic amplitude increased with cutter stretch length and input voltage, as expected. The amplitude remained constant when the cutter holding force exceeded 15 N. The experimental results showed that the ultrasonic amplitude had an optimum value with respect to surface finish. However, large amplitude ultrasonics did not necessarily improve quality. Furthermore, the cutters used for ultrasonic-assisted milling show less wear than those used for normal milling. It was also found that a positive rake angle and cutters with a large helix angle gave a better surface finish.
Supporting Teens with Chronic Pain to Obtain High School Credits: Chronic Pain 35 in Alberta
Authors: Reid Kathy , Simmonds Mark , Verrier Michelle , Dick Bruce
Published: November 2016

Chronic pain is a significant problem in children and teens, and adolescents with chronic pain often struggle to attend school on a regular basis. We present in this article a novel program we developed that integrates attendance at a group cognitive-behavioural chronic pain self-management program with earning high school credits. We collaborated with Alberta Education in the development of this course, Chronic Pain 35. Adolescents who choose to enroll are invited to demonstrate their scientific knowledge related to pain, understanding of and engagement with treatment homework, and demonstrate their creativity by completing a project, which demonstrates at least one concept. Integrating Chronic Pain 35 into an adolescent’s academic achievements is a creative strategy that facilitates the engagement of adolescents in learning and adopting pain coping techniques. It also helps teens to advocate for themselves in the school environment and improve their parents’ and teachers’ understanding of adolescent chronic pain. This is one of the first successful collaborations between a pediatric health program and provincial education leaders, aimed at integrating learning and obtaining school credit for learning about and engaging in health self-management for teens. The authors hope this paper serves as an effective reference model for any future collaborating programs aimed at supporting teens with chronic pain to obtain high school credits.
Neighborhood Characteristics: Influences on Pain and Physical Function in Youth at Risk for Chronic Pain
Authors: Schild Cathleen , Reed Emily , Hingston Tessa , Dennis Catlin , Wilson Anna
Published: November 2016

Neighborhood features such as community socioeconomic status, recreational facilities, and parks have been correlated to the health outcomes of the residents living within those neighborhoods, especially with regard to health-related quality of life, body mass index, and physical activity. The interplay between one’s built environment and one’s perceptions may affect physical health, well-being, and pain experiences. In the current study, neighborhood characteristics and attitudes about physical activity were examined in a high-risk (youths with a parent with chronic pain) and low-risk (youths without a parent with chronic pain) adolescent sample. There were significant differences in neighborhood characteristics between the high-risk (n = 62) and low-risk (n = 77) samples (ages 11–15), with low-risk participants living in residences with more walkability, closer proximity to parks, and higher proportion of neighborhood residents having college degrees. Results indicate that neighborhood features (e.g., walkability and proximity to parks), as well as positive attitudes about physical activity were correlated with lower levels of pain and pain-related disability, and higher performance in physical functioning tests. These findings suggest that the built environment may contribute to pain outcomes in youth, above and beyond the influence of family history of pain.
Inner-Shell Ionization and Fragmentation of Isolated Endohedral Fullerene Ions by XUV Radiation
Authors: Schippers Stefan
Published: November 2016

The photon–ion merged-beams technique for photoabsorption studies of ionized nanoparticles with synchrotron radiation is introduced. As an example, recent results from photoionization and photofragmentation of the endohedral fullerene ions Lu3 N @ C 80 + , Lu3 N @ C 80 2 + , and Lu3 N @ C 80 3 + are briefly discussed, highlighting the sensitivity and versatility of the experimental technique.
The Effect of Biogas Production on Farmland Rental Prices: Empirical Evidences from Northern Italy
Authors: Demartini Eugenio , Gaviglio Anna , Gelati Marco , Cavicchioli Daniele
Published: November 2016

In the last decade, increased environmental awareness has prompted the adoption of incentives for exploiting renewable energy sources. Among these, biogas production has received a certain attention in developed countries. Nonetheless, the subsidies provided have posed the problem of an activity (the production of bioenergy) that engages in direct competition with food and feed production for limited resources, like agricultural land. Even if this competition may be softened by allocating marginal land and/or using dedicated non-agricultural crops, empirical evidence shows that biogas plants have been developed in highly-productive agricultural areas, using increasing amounts of maize silage as feedstock. Thus, studies aimed at measuring the effect of biogas production on agricultural activities are needed in order to avoid this socially undesirable outcome. The paper presents an econometric estimation of the impact of biogas plants on farmland rental values of a Northern Italian rural area. Results show that biogas has a non-linear effect on rental prices, suggesting that incentive schemes specifically accounting for plants’ dimensions and technologies would improve the social sustainability of the bioenergy sector and its coexistence with agricultural activity.
A Detailed Assessment of the Wave Energy Resource at the Atlantic Marine Energy Test Site
Authors: Atan Reduan , Goggins Jamie , Nash Stephen
Published: November 2016

Wave characteristic assessments of wave energy test sites provide a greater understanding of prevailing wave conditions and are therefore extremely important to both wave energy test site operators and clients as they can inform wave energy converter design, optimisation, deployment, operation and maintenance. This research presents an assessment of the wave resource at the Atlantic Marine Energy Test Site (AMETS) on the west coast of Ireland based on 12-years of modelled data from January 2004 to December 2015. The primary aim is to provide an assessment of annual and seasonal wave characteristics and resource variability at the two deployment berths which comprise the site. A nested model has been developed using Simulating WAves Nearshore (SWAN) to replicate wave propagations from regional to local scale with a 0.05° resolution model covering the northeast Atlantic and a 0.0027° resolution model covering AMETS. The coarse and fine models have been extensively validated against available measured data within Irish waters. 12-year model outputs from the high resolution model were analysed to determine mean and maximum conditions and operational, high and extreme event conditions for significant wave height, energy period and power. Annual and seasonal analyses are presented. The 12-year annual mean P were 68 kW/m at Berth A (BA) and 57 kW/m at Berth B (BB). The resource shows strong seasonal and annual variations and the winter mean power levels were found to be strongly correlated with the North Atlantic Oscillation (NAO).
An Overview of Modeling Approaches Applied to Aggregation-Based Fleet Management and Integration of Plug-in Electric Vehicles †
Authors: You Shi , Hu Junjie , Ziras Charalampos
Published: November 2016

The design and implementation of management policies for plug-in electric vehicles (PEVs) need to be supported by a holistic understanding of the functional processes, their complex interactions, and their response to various changes. Models developed to represent different functional processes and systems are seen as useful tools to support the related studies for different stakeholders in a tangible way. This paper presents an overview of modeling approaches applied to support aggregation-based management and integration of PEVs from the perspective of fleet operators and grid operators, respectively. We start by explaining a structured modeling approach, i.e., a flexible combination of process models and system models, applied to different management and integration studies. A state-of-the-art overview of modeling approaches applied to represent several key processes, such as charging management, and key systems, such as the PEV fleet, is then presented, along with a detailed description of different approaches. Finally, we discuss several considerations that need to be well understood during the modeling process in order to assist modelers and model users in the appropriate decisions of using existing, or developing their own, solutions for further applications.
Suitability Assessment of an ICE-Based Micro-CCHP Unit in Different Spanish Climatic Zones: Application of an Experimental Model in Transient Simulation
Authors: Rey Guillermo , Ulloa Carlos , Míguez José , Cacabelos Antón
Published: November 2016

Tri-generation plants will have an important role in the near future in the residential sector where heating and cooling demands come into play throughout the year. Depending on the building’s location, the characteristics of its enclosure and its use, the thermal loads and demands will be different. This article analyses and compares a combined cooling, heating and power (CCHP) system tested in the laboratory and a single household located in Spain. The cooling capacity is obtained using a reversible heat pump where the compressor is driven directly by a gas engine with internal combustion engine (ICE) technology. The tests were carried out in a work bench at three different operating speeds. A variable-speed model is developed in the TRNSYS simulation environment with an operating strategy following the thermal load (FTL). Once the micro-CCHP system was modeled with experimental data and validated, it was dynamically simulated to analyze its performance in different climatic zones defined in the Spanish “Código Técnico de la Edificación” (CTE). This study reveals that the micro-CCHP system is suitable in mild weathers during the summer season.
Unconfined Unsteady Laminar Flow of a Power-Law Fluid across a Square Cylinder
Authors: Pantokratoras Asterios
Published: November 2016

The flow of a non-Newtonian, power-law fluid, directed normally to a horizontal cylinder with square cross-section (two-dimensional flow) is considered in the present paper. The problem is investigated numerically with a very large calculation domain in order that the flow could be considered unconfined. The investigation covers the power-law index from 0.1 up to 2 and the Reynolds number ranges from 60 to 160. Over this range of Reynolds numbers the flow is unsteady. It is found that the drag coefficient and the Strouhal number are higher in a confined flow compared to those of an unconfined flow. In addition some flow characteristics are lost in a confined flow. Complete results for the drag coefficient and Strouhal number in the entire shear-thinning and shear-thickening region have been produced. In shear-thinning fluids chaotic structures exist which diminish at higher values of power-law index. This study represents the first investigation of unsteady, non-Newtonian power-law flow past a square cylinder in an unconfined field.
Crash Risk Prediction Modeling Based on the Traffic Conflict Technique and a Microscopic Simulation for Freeway Interchange Merging Areas
Authors: Li Shen , Xiang Qiaojun , Ma Yongfeng , Gu Xin , Li Han
Published: November 2016

This paper evaluates the traffic safety of freeway interchange merging areas based on the traffic conflict technique. The hourly composite risk indexes (HCRI) was defined. By the use of unmanned aerial vehicle (UAV) photography and video processing techniques, the conflict type and severity was judged. Time to collision (TTC) was determined with the traffic conflict evaluation index. Then, the TTC severity threshold was determined. Quantizing the weight of the conflict by direct losses of different severities of freeway traffic accidents, the calculated weight of the HCRI can be obtained. Calibration of the relevant parameters of the micro-simulation simulator VISSIM is conducted by the travel time according to the field data. Variables are placed into orthogonal tables at different levels. On the basis of this table, the trajectory file of every traffic condition is simulated, and then submitted into a surrogate safety assessment model (SSAM), identifying the number of hourly traffic conflicts in the merging area, a statistic of HCRI. Moreover, the multivariate linear regression model was presented and validated to study the relationship between HCRI and the influencing variables. A comparison between the HCRI model and the hourly conflicts ratio (HCR), without weight, shows that the HCRI model fitting degree was obviously higher than the HCR. This will be a reference to design and implement operational planners.
Auditing the Immunization Data Quality from Routine Reports in Shangyu District, East China
Authors: Hu Yu , Zhang Xinpei , Li Qian , Chen Yaping
Published: November 2016

Objective: To evaluate the immunization data quality in Shangyu District, East China. Methods: An audit for immunization data for the year 2014 was conducted in 20 vaccination clinics of Shangyu District. The consistency of immunization data was estimated by verification factors (VFs), which was the proportion of vaccine doses reported as being administered that could be verified by written documentation at vaccination clinics. The quality of monitoring systems was evaluated using the quality index (QI). Results: The VFs of 20 vaccine doses ranged from 0.94 to 1.04 at the district level. The VFs for the 20 vaccination clinics ranged from 0.57 to 1.07. The VFs for Shangyu District was 0.98. The mean of total QI score of the 20 vaccination clinics was 80.32%. A significant correlation between the VFs of the 3rd dose of the diphtheria–tetanus–pertussis combined vaccine (DTP) and QI scores was observed at the vaccination clinic level. Conclusions: Deficiencies in data consistency and immunization reporting practice in Shangyu District were observed. Targeted measures are suggested to improve the quality of the immunization reporting system in vaccination clinics with poor data consistency.
Low Expression of CAPON in Glioma Contributes to Cell Proliferation via the Akt Signaling Pathway
Authors: Gao Shangfeng , Wang Jie , Zhang Tong , Liu Guangping , Jin Lei , Ji Daofei , Wang Peng , Meng Qingming , Zhu Yufu , Yu Rutong
Published: November 2016

CAPON is an adapter protein for nitric oxide synthase 1 (NOS1). CAPON has two isoforms in the human brain: CAPON-L (long form of CAPON) and CAPON-S (short form of CAPON). Recent studies have indicated the involvement of CAPON in tumorigenesis beyond its classical role in NOS1 activity regulation. In this study, we found that the protein levels of CAPON-S, but not than CAPON-L, were significantly decreased in glioma tissues. Therefore, we established lentivirus-mediated stable cell lines with CAPON-S overexpression or down-regulation, and investigated the role of CAPON-S in the proliferation of glioma cells by using CCK8, EdU, and flow cytometry assays. Overexpression of CAPON-S reduced the cell variability and the percentage of EdU-positive cells, and arrested the cells in the G1 phase in glioma cells. Silencing of CAPON by short-hairpin RNA showed the opposite effects. Furthermore, an intracellular signaling array revealed that overexpression of CAPON-S resulted in a remarkable reduction in the phosphorylation of Akt and S6 ribosomal protein in glioma cells, which was further confirmed by Western blot. These findings suggest that CAPON may function as a tumor suppressor in human brain glioma and that the inactivation of the Akt signaling pathway caused by CAPON-S overexpression may provide insight into the underlying mechanism of CAPON in glioma cell proliferation.
Transcriptome Analysis Identifies Key Candidate Genes Mediating Purple Ovary Coloration in Asiatic Hybrid Lilies
Authors: Xu Leifeng , Yang Panpan , Yuan Suxia , Feng Yayan , Xu Hua , Cao Yuwei , Ming Jun
Published: November 2016

Lily tepals have a short lifespan. Once the tepals senesce, the ornamental value of the flower is lost. Some cultivars have attractive purple ovaries and fruits which greatly enhance the ornamental value of Asiatic hybrid lilies. However, little is known about the molecular mechanisms of anthocyanin biosynthesis in Asiatic hybrid lily ovaries. To investigate the transcriptional network that governs purple ovary coloration in Asiatic hybrid lilies, we obtained transcriptome data from green ovaries (S1) and purple ovaries (S2) of Asiatic “Tiny Padhye”. Comparative transcriptome analysis revealed 4228 differentially expressed genes. Differential expression analysis revealed that ten unigenes including four CHS genes, one CHI gene, one F3H gene, one F3′H gene, one DFR gene, one UFGT gene, and one 3RT gene were significantly up-regulated in purple ovaries. One MYB gene, LhMYB12-Lat, was identified as a key transcription factor determining the distribution of anthocyanins in Asiatic hybrid lily ovaries. Further qPCR results showed unigenes related to anthocyanin biosynthesis were highly expressed in purple ovaries of three purple-ovaried Asiatic hybrid lilies at stages 2 and 3, while they showed an extremely low level of expression in ovaries of three green-ovaried Asiatic hybrid lilies during all developmental stages. In addition, shading treatment significantly decreased pigment accumulation by suppressing the expression of several unigenes related to anthocyanin biosynthesis in ovaries of Asiatic “Tiny Padhye”. Lastly, a total of 15,048 Simple Sequence Repeats (SSRs) were identified in 13,710 sequences, and primer pairs for SSRs were designed. The results could further our understanding of the molecular mechanisms of anthocyanin biosynthesis in Asiatic hybrid lily ovaries.
Insect Gallers and Their Plant Hosts: From Omics Data to Systems Biology
Authors: Oates Caryn , Denby Katherine , Myburg Alexander , Slippers Bernard , Naidoo Sanushka
Published: November 2016

Gall-inducing insects are capable of exerting a high level of control over their hosts’ cellular machinery to the extent that the plant’s development, metabolism, chemistry, and physiology are all altered in favour of the insect. Many gallers are devastating pests in global agriculture and the limited understanding of their relationship with their hosts prevents the development of robust management strategies. Omics technologies are proving to be important tools in elucidating the mechanisms involved in the interaction as they facilitate analysis of plant hosts and insect effectors for which little or no prior knowledge exists. In this review, we examine the mechanisms behind insect gall development using evidence from omics-level approaches. The secretion of effector proteins and induced phytohormonal imbalances are highlighted as likely mechanisms involved in gall development. However, understanding how these components function within the system is far from complete and a number of questions need to be answered before this information can be used in the development of strategies to engineer or breed plants with enhanced resistance.
Design of New Antibacterial Enhancers Based on AcrB’s Structure and the Evaluation of Their Antibacterial Enhancement Activity
Authors: Song Yi , Qin Rongxin , Pan Xichun , Ouyang Qin , Liu Tianyu , Zhai Zhaoxia , Chen Yingchun , Li Bin , Zhou Hong
Published: November 2016

Previously, artesunate (AS) and dihydroartemisinine 7 (DHA7) were found to have antibacterial enhancement activity against Escherichia coli via inhibition of the efflux pump AcrB. However, they were only effective against E. coli standard strains. This study aimed to develop effective antibacterial enhancers based on the previous work. Our results demonstrate that 86 new antibacterial enhancers were designed via 3D-SAR and molecular docking. Among them, DHA27 had the best antibacterial enhancement activity. It could potentiate the antibacterial effects of ampicillin against not only E. coli standard strain but also clinical strains, and of β-lactam antibiotics, not non-β-lactamantibiotics. DHA27 could increase the accumulation of daunomycin and nile red within E. coli ATCC 35218, but did not increase the bacterial membrane permeability. DHA27 reduced acrB’s mRNA expression of E. coli ATCC 35218 in a dose-dependent manner, and its antibacterial enhancement activity is related to the degree of acrB mRNA expression in E. coli clinical strains. The polypeptides from AcrB were obtained via molecular docking assay; the pre-incubated polypeptides could inhibit the activity of DHA27. Importantly, DHA27 had no cytotoxicity on cell proliferation. In conclusion, among newly designed antibacterial enhancers, DHA27 had favorable physical and pharmacological properties with no significant cytotoxicity at effective concentrations, and might serve as a potential efflux pump inhibitor in the future.
Clinical Decision-Making in the Treatment of Schizophrenia: Focus on Long-Acting Injectable Antipsychotics
Authors: Samalin Ludovic , Garnier Marion , Auclair Candy , Llorca Pierre-Michel
Published: November 2016

The purpose of this study was to identify clinician characteristics associated with higher prescription rates of long-acting injectable (LAI) antipsychotics, as well as the sources that influence medical decision-making regarding the treatment of schizophrenia. We surveyed 202 psychiatrists during six regional French conferences (Bordeaux, Lyon, Marseille, Nice, Paris, and Strasbourg). Data on the characteristics of practice, prescription rates of antipsychotic, and information sources about their clinical decisions were collected. Most psychiatrists used second-generation antipsychotics (SGAs), and preferentially an oral formulation, in the treatment of schizophrenia. LAI SGAs were prescribed to 30.4% of schizophrenic patients. The duration and type of practice did not influence the class or formulation of antipsychotics used. The clinicians following the higher percentage of schizophrenic patients were associated with a higher use of LAI antipsychotics and a lower use of oral SGAs. Personal experience, government regulatory approval, and guidelines for the treatment of schizophrenia were the three main contributing factors guiding clinicians’ decision-making regarding the treatment of schizophrenia. The more clinicians follow schizophrenic patients, the more they use LAI antipsychotics. The development of specialized programs with top specialists should lead to better use of LAI antipsychotics in the treatment of schizophrenia.
Synthesis of Non-Toxic Silica Particles Stabilized by Molecular Complex Oleic-Acid/Sodium Oleate
Authors: Spataru Catalin , Ianchis Raluca , Petcu Cristian , Nistor Cristina , Purcar Violeta , Trica Bogdan , Nitu Sabina , Somoghi Raluca , Alexandrescu Elvira , Oancea Florin , Donescu Dan
Published: November 2016

The present work is focused on the preparation of biocompatible silica particles from sodium silicate, stabilized by a vesicular system containing oleic acid (OLA) and its alkaline salt (OLANa). Silica nanoparticles were generated by the partial neutralization of oleic acid (OLA), with the sodium cation present in the aqueous solutions of sodium silicate. At the molar ratio OLA/Na+ = 2:1, the molar ratio (OLA/OLANa = 1:1) required to form vesicles, in which the carboxyl and carboxylate groups have equal concentrations, was achieved. In order to obtain hydrophobically modified silica particles, octadecyltriethoxysilane (ODTES) was added in a sodium silicate sol–gel mixture at different molar ratios. The interactions between the octadecyl groups from the modified silica and the oleyl chains from the OLA/OLANa stabilizing system were investigated via simultaneous thermogravimetry (TG) and differential scanning calorimetry (DSC) (TG-DSC) analyses.A significant decrease in vaporization enthalpy and an increase in amount of ODTES were observed. Additionally, that the hydrophobic interaction between OLA and ODTES has a strong impact on the hybrids’ final morphology and on their textural characteristics was revealed. The highest hydrodynamic average diameter and the most negative ζ potential were recorded for the hybrid in which the ODTES/sodium silicate molar ratio was 1:5. The obtained mesoporous silica particles, stabilized by the OLA/OLANa vesicular system, may find application as carriers for hydrophobic bioactive molecules.
The Vitamin E Analog Gamma-Tocotrienol (GT3) and Statins Synergistically Up-Regulate Endothelial Thrombomodulin (TM)
Authors: Pathak Rupak , Ghosh Sanchita , Zhou Daohong , Hauer-Jensen Martin
Published: November 2016

Statins; a class of routinely prescribed cholesterol-lowering drugs; inhibit 3-hydroxy-3-methylglutaryl-coenzymeA reductase (HMGCR) and strongly induce endothelial thrombomodulin (TM); which is known to have anti-inflammatory; anti-coagulation; anti-oxidant; and radioprotective properties. However; high-dose toxicity limits the clinical use of statins. The vitamin E family member gamma-tocotrienol (GT3) also suppresses HMGCR activity and induces TM expression without causing significant adverse side effects; even at high concentrations. To investigate the synergistic effect of statins and GT3 on TM; a low dose of atorvastatin and GT3 was used to treat human primary endothelial cells. Protein-level TM expression was measured by flow cytometry. TM functional activity was determined by activated protein C (APC) generation assay. Expression of Kruppel-like factor 2 (KLF2), one of the key transcription factors of TM, was measured by quantitative reverse transcription polymerase chain reaction (qRT-PCR). TM expression increased in a dose-dependent manner after both atorvastatin and GT3 treatment. A combined treatment of a low-dose of atorvastatin and GT3 synergistically up-regulated TM expression and functional activity. Finally; atorvastatin and GT3 synergistically increased KLF2 expression. These findings suggest that combined treatment of statins with GT3 may provide significant health benefits in treating a number of pathophysiological conditions; including inflammatory and cardiovascular diseases.
Studying the Hydration of a Retarded Suspension of Ground Granulated Blast-Furnace Slag after Reactivation
Authors: Schneider Nick , Stephan Dietmar
Published: November 2016

This article presents a combined use of a retarder (d-gluconic acid) and an alkaline activator (sodium hydroxide) in a binder system based on ground granulated blast-furnace slag. The properties of the retarder are extending the dormant hydration period and suppressing the generation of strength-giving phases. Different retarder concentrations between 0.25 and 1.00 wt.% regulate the intensity and the period of the retardation and also the characteristics of the strength development. The activator concentration of 30 and 50 wt.% regulates the overcoming of the dormant period and thereby the solution of the slag and hence the formation of the hydration products. The research objective is to produce a mineral binder system based on two separate liquid components. The highest concentration of retarder and activator generates the highest compressive strength and mass of hydration products—after 90 days of hydration a compressive strength of more than 50 N/mm2. The main phases are calcium silicate hydrate and hydrotalcite. Generally, the combination of retarder and activator shows a high potential in the performance increase of the hydration process.
Molecular Weight Cut-Off and Structural Analysis of Vacuum-Assisted Titania Membranes for Water Processing
Authors: Abd Jalil Siti , Wang David , Yacou Christelle , Motuzas Julius , Smart Simon , Diniz da Costa João
Published: November 2016

This work investigates the structural formation and analyses of titania membranes (TM) prepared using different vacuum exposure times for molecular weight (MW) cut-off performance and oil/water separation. Titania membranes were synthesized via a sol-gel method and coated on macroporous alumina tubes followed by exposure to a vacuum between 30 and 1200 s and then calcined at 400 °C. X-ray diffraction and nitrogen adsorption analyses showed that the crystallite size and particle size of titania increased as a function of vacuum time. All the TM membranes were mesoporous with an average pore diameter of ~3.6 nm with an anatase crystal morphology. Water, glucose, sucrose, and polyvinylpyrrolidone with 40 and 360 kDa (PVP-40 kDa and PVP-360 kDa) were used as feed solutions for MW cut-off and hexadecane solution for oil filtration investigation. The TM membranes were not able to separate glucose and sucrose, thus indicating the membrane pore sizes are larger than the kinetic diameter of sucrose of 0.9 nm, irrespective of vacuum exposure time. They also showed only moderate rejection (20%) of the smaller PVP-40 kDa, however, all the membranes were able to obtain an excellent rejection of near 100% for the larger PVP-360 kDa molecule. Furthermore, the TM membranes were tested for the separation of oil emulsions with a high concentration of oil (3000 ppm), reaching high oil rejections of more than 90% of oil. In general, the water fluxes increased with the vacuum exposure time indicating a pore structural tailoring effect. It is therefore proposed that a mechanism of pore size tailoring was formed by an interconnected network of Ti–O–Ti nanoparticles with inter-particle voids, which increased as TiO2 nanoparticle size increased as a function of vacuum exposure time, and thus reduced the water transport resistance through the TM membranes.
Magneto-Luminescence Correlation in the Textbook Dysprosium(III) Nitrate Single-Ion Magnet
Authors: Mamontova Ekaterina , Long Jérôme , Ferreira Rute , Botas Alexandre , Luneau Dominique , Guari Yannick , Carlos Luis , Larionova Joulia
Published: November 2016

Multifunctional Single-Molecule Magnets (SMMs) or Single-Ion Magnets (SIMs) are intriguing molecule-based materials presenting an association of the slow magnetic relaxation with other physical properties. In this article, we present an example of a very simple molecule based on Dy3+ ion exhibiting a field induced SIM property and a characteristic Dy3+ based emission. The [Dy(NO3)3(H2O)4]·2H2O (1) complex is characterized by the means of single crystal X-Ray diffraction and their magnetic and photo-luminescent properties are investigated. We demonstrate here that it is possible to correlate the magnetic and luminescent properties and to obtain the Orbach barrier from the low temperature emission spectra, which is often difficult to properly extract from the magnetic measurements, especially in the case of field induced SIMs.
Distribution of Type I Restriction–Modification Systems in Streptococcus suis: An Outlook
Authors: Willemse Niels , Schultsz Constance
Published: November 2016

Streptococcus suis is a porcine commensal and pathogen with zoonotic potential. We recently identified a novel Type I restriction–modification (R–M) system in a zoonotic S. suis clone which has emerged in the Netherlands. Here, we describe the DNA inversions in the specificity subunit of this system in S. suis serotype 2, clonal complex 20 and explain the absence of domain movement by the absence of repeats. In addition, we identified a core Type I R–M system present in 95% of the isolates and found an association of the distribution of Type I R–M systems in the S. suis genome with population structure. We speculate on the potential role of Type I R–M systems in S. suis given the recently described associations of Type I R–M systems with virulence and propose future research directions.
Faith and Form on Screen
Authors: Bacon Henry
Published: November 2016

To understand any aspect of being-in-the-world in general or cinematic experience in particular, both reductionist and holistic approaches are needed. Psychological accounts can give us only functional explanations of human behaviour or responses to signifying artifacts such as art. To understand the significance of these experiences the psychological must be complemented by a study on a level which may be termed spiritual. This line of thought is applied to analyses of Robert Bresson’s Pickpocket, starting from David Bordwell’s formalist and cognitive account of why many people experience this film as religious despite there being no explicit reference to religion. Paul Schrader’s analysis of the formal structure of this film in terms of his notion of transcendental style in film goes a step forward by explaining how the formal structure as he analyses it suggests a transcendental dimension which cannot be addressed directly. This approach connects in an illuminating way with Slavoj Žižek’s notions of the imaginary and the symbolic sphere. Bordwell’s approach, functioning on the psychological level, is basically reductionist, while Schrader’s, boosted with Žižek’s ideas as appropriated for the purposes of this article, is holistic and operative on the spiritual level. This two-tiered analysis reveals how cinematic form in Pickpocket serves as an indirect expression of faith.
Simulation of Attacks for Security in Wireless Sensor Network
Authors: Diaz Alvaro , Sanchez Pablo
Published: November 2016

The increasing complexity and low-power constraints of current Wireless Sensor Networks (WSN) require efficient methodologies for network simulation and embedded software performance analysis of nodes. In addition, security is also a very important feature that has to be addressed in most WSNs, since they may work with sensitive data and operate in hostile unattended environments. In this paper, a methodology for security analysis of Wireless Sensor Networks is presented. The methodology allows designing attack-aware embedded software/firmware or attack countermeasures to provide security in WSNs. The proposed methodology includes attacker modeling and attack simulation with performance analysis (node’s software execution time and power consumption estimation). After an analysis of different WSN attack types, an attacker model is proposed. This model defines three different types of attackers that can emulate most WSN attacks. In addition, this paper presents a virtual platform that is able to model the node hardware, embedded software and basic wireless channel features. This virtual simulation analyzes the embedded software behavior and node power consumption while it takes into account the network deployment and topology. Additionally, this simulator integrates the previously mentioned attacker model. Thus, the impact of attacks on power consumption and software behavior/execution-time can be analyzed. This provides developers with essential information about the effects that one or multiple attacks could have on the network, helping them to develop more secure WSN systems. This WSN attack simulator is an essential element of the attack-aware embedded software development methodology that is also introduced in this work.
Virtual Distances Methodology as Verification Technique for AACMMs with a Capacitive Sensor Based Indexed Metrology Platform
Authors: Acero Raquel , Santolaria Jorge , Brau Agustin , Pueo Marcos
Published: November 2016

This paper presents a new verification procedure for articulated arm coordinate measuring machines (AACMMs) together with a capacitive sensor-based indexed metrology platform (IMP) based on the generation of virtual reference distances. The novelty of this procedure lays on the possibility of creating virtual points, virtual gauges and virtual distances through the indexed metrology platform’s mathematical model taking as a reference the measurements of a ball bar gauge located in a fixed position of the instrument’s working volume. The measurements are carried out with the AACMM assembled on the IMP from the six rotating positions of the platform. In this way, an unlimited number and types of reference distances could be created without the need of using a physical gauge, therefore optimizing the testing time, the number of gauge positions and the space needed in the calibration and verification procedures. Four evaluation methods are presented to assess the volumetric performance of the AACMM. The results obtained proved the suitability of the virtual distances methodology as an alternative procedure for verification of AACMMs using the indexed metrology platform.
Wireless Mid-Infrared Spectroscopy Sensor Network for Automatic Carbon Dioxide Fertilization in a Greenhouse Environment
Authors: Wang Jianing , Niu Xintao , Zheng Lingjiao , Zheng Chuantao , Wang Yiding
Published: November 2016

In this paper, a wireless mid-infrared spectroscopy sensor network was designed and implemented for carbon dioxide fertilization in a greenhouse environment. A mid-infrared carbon dioxide (CO2) sensor based on non-dispersive infrared (NDIR) with the functionalities of wireless communication and anti-condensation prevention was realized as the sensor node. Smart transmission power regulation was applied in the wireless sensor network, according to the Received Signal Strength Indication (RSSI), to realize high communication stability and low-power consumption deployment. Besides real-time monitoring, this system also provides a CO2 control facility for manual and automatic control through a LabVIEW platform. According to simulations and field tests, the implemented sensor node has a satisfying anti-condensation ability and reliable measurement performance on CO2 concentrations ranging from 30 ppm to 5000 ppm. As an application, based on the Fuzzy proportional, integral, and derivative (PID) algorithm realized on a LabVIEW platform, the CO2 concentration was regulated to some desired concentrations, such as 800 ppm and 1200 ppm, in 30 min with a controlled fluctuation of <±35 ppm in an acre of greenhouse.
The Development of a Gas–Liquid Two-Phase Flow Sensor Applicable to CBM Wellbore Annulus
Authors: Wu Chuan , Wen Guojun , Han Lei , Wu Xiaoming
Published: November 2016

The measurement of wellbore annulus gas–liquid two-phase flow in CBM (coalbed methane) wells is of great significance for reasonably developing gas drainage and extraction processes, estimating CBM output, judging the operating conditions of CBM wells and analyzing stratum conditions. Hence, a specially designed sensor is urgently needed for real-time measurement of gas–liquid two-phase flow in CBM wellbore annulus. Existing flow sensors fail to meet the requirements of the operating conditions of CBM wellbore annulus due to such factors as an inapplicable measurement principle, larger size, poor sealability, high installation accuracy, and higher requirements for fluid media. Therefore, based on the principle of a target flowmeter, this paper designs a new two-phase flow sensor that can identify and automatically calibrate different flow patterns of two-phase flows. Upon the successful development of the new flow sensor, lab and field tests were carried out, and the results show that the newly designed sensor, with a measurement accuracy of ±2.5%, can adapt to the operating conditions of CBM wells and is reliable for long-term work.
Highly Sensitive and Practical Detection of Plant Viruses via Electrical Impedance of Droplets on Textured Silicon-Based Devices
Authors: Ambrico Marianna , Ambrico Paolo , Minafra Angelantonio , De Stradis Angelo , Vona Danilo , Cicco Stefania , Palumbo Fabio , Favia Pietro , Ligonzo Teresa
Published: November 2016

Early diagnosis of plant virus infections before the disease symptoms appearance may represent a significant benefit in limiting disease spread by a prompt application of appropriate containment steps. We propose a label-free procedure applied on a device structure where the electrical signal transduction is evaluated via impedance spectroscopy techniques. The device consists of a droplet suspension embedding two representative purified plant viruses i.e., Tomato mosaic virus and Turnip yellow mosaic virus, put in contact with a highly hydrophobic plasma textured silicon surface. Results show a high sensitivity of the system towards the virus particles with an interestingly low detection limit, from tens to hundreds of attomolar corresponding to pg/mL of sap, which refers, in the infection time-scale, to a concentration of virus particles in still-symptomless plants. Such a threshold limit, together with an envisaged engineering of an easily manageable device, compared to more sophisticated apparatuses, may contribute in simplifying the in-field plant virus diagnostics.
Context-Aware Fusion of RGB and Thermal Imagery for Traffic Monitoring
Authors: Alldieck Thiemo , Bahnsen Chris , Moeslund Thomas
Published: November 2016

In order to enable a robust 24-h monitoring of traffic under changing environmental conditions, it is beneficial to observe the traffic scene using several sensors, preferably from different modalities. To fully benefit from multi-modal sensor output, however, one must fuse the data. This paper introduces a new approach for fusing color RGB and thermal video streams by using not only the information from the videos themselves, but also the available contextual information of a scene. The contextual information is used to judge the quality of a particular modality and guides the fusion of two parallel segmentation pipelines of the RGB and thermal video streams. The potential of the proposed context-aware fusion is demonstrated by extensive tests of quantitative and qualitative characteristics on existing and novel video datasets and benchmarked against competing approaches to multi-modal fusion.
Probabilistic Model Updating for Sizing of Hole-Edge Crack Using Fiber Bragg Grating Sensors and the High-Order Extended Finite Element Method
Authors: He Jingjing , Yang Jinsong , Wang Yongxiang , Waisman Haim , Zhang Weifang
Published: November 2016

This paper presents a novel framework for probabilistic crack size quantification using fiber Bragg grating (FBG) sensors. The key idea is to use a high-order extended finite element method (XFEM) together with a transfer (T)-matrix method to analyze the reflection intensity spectra of FBG sensors, for various crack sizes. Compared with the standard FEM, the XFEM offers two superior capabilities: (i) a more accurate representation of fields in the vicinity of the crack tip singularity and (ii) alleviation of the need for costly re-meshing as the crack size changes. Apart from the classical four-term asymptotic enrichment functions in XFEM, we also propose to incorporate higher-order functions, aiming to further improve the accuracy of strain fields upon which the reflection intensity spectra are based. The wavelength of the reflection intensity spectra is extracted as a damage sensitive quantity, and a baseline model with five parameters is established to quantify its correlation with the crack size. In order to test the feasibility of the predictive model, we design FBG sensor-based experiments to detect fatigue crack growth in structures. Furthermore, a Bayesian method is proposed to update the parameters of the baseline model using only a few available experimental data points (wavelength versus crack size) measured by one of the FBG sensors and an optical microscope, respectively. Given the remaining data points of wavelengths, even measured by FBG sensors at different positions, the updated model is shown to give crack size predictions that match well with the experimental observations.