bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeted Drug Delivery for Precision Mitochondrial Therapy in Osteoporosis: Therapeutic Strategies and Advances
Authors: He Junyi , Zeng Wenxuan , Ye Xiaoyun , Niu Xiaoshuang , Liu Juan , Chen Zhihui
Published: September 2024

:

Osteoporosis (OP) remains a significant global health challenge, marked by high prevalence
and considerable economic burden, yet effective therapeutic options remain limited. Central to
the pathogenesis of OP is mitochondrial dysfunction, which adversely impacts bone formation and
resorption. This review provides an in-depth analysis of the complex relationship between mitochondrial
function and OP, elucidating critical molecular mechanisms and identifying promising therapeutic
agents. Among these, zoledronic acid and resveratrol stand out, demonstrating significant efficacy
in enhancing mitochondrial functions and enhancing bone density in both preclinical models
and clinical trials. Moreover, innovative drug delivery systems, such as mitochondrial-targeted
nanodelivery systems and localized delivery methods, have been developed to ensure precise targeting
and reduce systemic side effects, thereby enhancing bioavailability and therapeutic outcomes. By
delving into these advancements, this review seeks to facilitate the translation of mitochondrial-targeted
therapies from preclinical research to clinical application, ultimately advancing OP management
and improving patient outcomes.
Phytochemical Characterization of the Aerial Parts of Teucrium nuchense K. Koch: An Endemic Species of Caucasian Flora
Authors: Korkotadze Teona , Berashvili Dali , Gokadze Sopio , Jokhadze Malkhaz , Bozhadze Anna , Gviniashvili Tsiala , Getia Malkhaz , Pichette André , Legault Jean , Mshvildadze Vakhtang
Published: September 2024

Background:

The genus Teucrium L. is frequently employed in traditional medicine, primarily
for addressing disorders of the digestive and respiratory systems. Biological investigations
focused on essential oils have substantiated their antibacterial, antioxidant, anti-tumor, anti-diabetic,
and anti-rheumatic properties.

Objective:

The aim of the study was to assess the chemical composition and biological activities of
the aerial parts of the endemic species Teucrium nuchense K. Koch.

Methods:

The chemical composition of the essential oil was analyzed using gas chromatography-mass
spectrometry (GC-MS). The antioxidant activity was evaluated through the Oxygen Radical Absorbance
Capacity (ORAC) assay and tested on normal skin fibroblasts (WS-1). Additionally, the antiinflammatory
efficacy was assessed by monitoring nitric oxide production. The total phenolic content in
the aqueous, methanolic, and chloroformic extracts was quantified using the Folin-Ciocalteu reagent.
Individual compounds were isolated using preparative high-performance liquid chromatography. Their
identification was accomplished using high-resolution mass spectrometry (HRMS) with an ESI-Q-TOF
detector in conjunction with nuclear magnetic resonance (NMR) spectroscopy.

Results:

The essential oil yield was 0.32 ml/kg. Caryophyllene oxide, constituting 15.19 %, and 1-
octen-3-ol, constituting 8.75%, emerged as the primary components in the essential oil. Oxygenated
sesquiterpenes dominated the terpenic compounds, representing 25.1 % of the essential oil. The
aqueous and methanolic extracts displayed a notable phenolic content, with percentages of 27 ± 2 %
and 35 ± 0.1 %, respectively. Both the aqueous and methanolic extracts demonstrated robust antioxidant
activity in the ORAC test and in vitro assessments using WS-1 cells. The methanolic extract, at
a concentration of 160 μg/ml, inhibited NO formation by 90 %, without toxicity in RAW 264.7. Individual
compounds, teucrioside from the phenylethanoid glycoside class, two neo-clerodane diterpenes,
teucrin A, and 6-alpha-hydroxyteuscordine, were isolated.

Conclusion:

The essential oil extracted from the aerial parts of Teucrium nuchense is characterized
by the presence of caryophyllene oxide and 1-octen-3-ol. The methanolic extract exhibits notable
antioxidant as well as anti-inflammatory properties, whereas the aqueous extract demonstrates high
antioxidant activity. Additionally, three compounds of teucrioside, teucrin A, and 6-α-
hydroxyteuscordine have been isolated and characterized.
Method Development and Validation of Stability-Indicating HPLC-UV Method for Determination of 5 -Fluorouracil
Authors: Gulati Diksha , Arora Deepshi , Taneja Yugam , Dhingra Ashwani
Published: September 2024

Introduction:

In the realm of pharmaceutical analysis, the development and validation of a High-Performance Liquid Chromatography with Ultraviolet Detection (HPLC-UV) method for the precise determination of 5-FU stand as a crucial endeavor.

Methods:

This study outlines the systematic process of method development, optimization, and subsequent validation to ensure the reliability and applicability of the method in pharmaceutical quality control. Method optimization included the selection of an appropriate stationary phase, mobile phase composition, and chromatographic conditions to achieve optimum resolution, sensi-tivity, and run time.

Results:

A speedy, simple, and dependable HPLC technique for quantifying 5-FU on a C18 (250 4.6 mm, 5m particle size) column with solvent A included 10 mM phosphate buffer with pH 3.0 and solvent B with acetonitrile as the mobile phase. At 250 nm, the effluent was measured. Fur-ther, 5-FU had a retention time of 1.698 minutes.

Conclusion:

According to ICH criteria, the devised technique was validated for precision, accu-racy, linearity range, robustness, and ruggedness.
Financial Dynamics in Cell and Gene Therapy Development: Navigating Valuation and Fundraising Challenges
Authors: Williamson Joab , Spicer Alexander , Colcomb Pierre-Albert
Published: September 2024

:

Cell and gene therapy, offering unprecedented solutions for complex diseases, have
attracted significant attention in both the scientific and financial communities. This article
explores the tumultuous financial journey of companies specializing in these advanced therapeutic
modalities. The discussion illuminates the volatility of share prices, challenges in
valuation, and complexities in fundraising while delving into the inherent risks of the cell and
gene therapy development pathway. Through an examination of various strategies, the article
underscores the importance of diverse investment sources, robust collaborations, risk-sharing
models, and portfolio diversification in ensuring financial stability. As the field burgeons, understanding
these financial dynamics is paramount for stakeholders aiming to harness the
transformative potential of cell and gene therapies.
ANALISIS KONTRIBUSI SEKTOR KOMODITAS KARET TERHADAP PERTUMBUHAN EKONOMI KABUPATEN BANYUASIN TAHUN 2016-2021
Authors: Zulhan Muhamad Zulhan Fikri , Nurul Badriyah
Published: September 2024

This research aims to analyze the contribution of the rubber commodity sector to the economic growth of Banyuasin Regency from 2016 to 2021, along with the specialization level of this sector. The study employs a quantitative research method designed to illustrate correlations with appropriate reliability and priority levels. Analytical methods utilized include Location Quotient (LQ) and Shift-share (SS). Secondary data for the research are sourced from the Central Statistics Agency (BPS) of Banyuasin Regency and South Sumatra Province. The findings reveal that, among the 21 sub-districts in Banyuasin Regency, a majority exhibit rubber plantation as their primary sub-sector, evident from the average LQ calculations. The LQ and Shift-share results, where LQ>1 and PPW>0, indicate that 10 sub-districts serve as the base sectors for the rubber commodity, positively impacting the economy of Banyuasin Regency. Moreover, six sub-districts with LQ>1 and PPW<0 show that high production values and rubber plantation mobility contribute negatively due to less effective supporting mobility, thereby preventing high yields from translating into positive economic values for Banyuasin Regency. Additionally, five sub-districts with LQ<1 signify that rubber plantations have not yet emerged as leading sectors in these areas.
ANALISIS PENGGUNAAN UANG ELEKTRONIK TERHADAP PERTUMBUHAN EKONOMI: STUDI EMPIRIS INDONESIA TAHUN 2014-2021
Authors: Febitania Nabila Zakia , Agus Suman
Published: September 2024

The use of modern technology is growing rapidly, with innovation leading to the increasing replacement of cash transactions by electronic payments. This trend is reflected in the value of electronic money transactions which continues to increase, reaching IDR 786.35 trillion in 2021. Thus, the aim of this research is to assess how Indonesia's economic growth is influenced by the use of electronic payment systems. The study approach examines possible short-term and long-term relationships between electronic money, money supply, interest rates, inflation and economic growth using the Vector Error Correction Model (VECM). Using documentation techniques, data on GDP, money supply, electronic money transactions, interest rates and inflation were collected from Bank Indonesia and the Central Statistics Agency between 2014 and 2021. According to research, there is a short-term relationship between economic growth and the use of electronic money. However, as time goes by, economic growth is only influenced by the positive relationship between inflation and the money supply. These results are intended to provide insight for decision makers in Indonesia to continue to innovate in the development of electronic money to support sustainable economic growth.
ANALISIS PENGARUH JUMLAH PENDUDUK, PRODUK DOMESTIK REGIONAL BRUTO (PDRB), INFLASI DAN JUMLAH TENAGA KERJA TERHADAP PENDAPATAN ASLI DAERAH (PAD) KOTA MALANG TAHUN 2012-2021
Authors: Surya Andriansyah Afwanda , Moh. Athoillah
Published: September 2024

This study aims to determine the effect of total   population,   Gross   Regional Domestic Product (GDP), inflation and total employment to Region Own-Source Revenue (PAD) in 2012-2021. This study used qualitative approach and literature review method. The data were obtained from Central Bureau of Statistics and the annual financial reports of Malang City through the official website which can be accessed by the public. The results of this study indicated that the variables of total population, inflation and total employment do not have a significant influence on Region Own-Source Revenue (PAD). However, Gross Regional Domestic Product (GDP) has a positive and significant influence on Region Own-Source Revenue (PAD). Meanwhile, total population, Gross Regional Domestic Product (GDP), inflation and total employment have a simultaneous influence of 96,4% on Region Own-Source Revenue (PAD).
PENGARUH PMDN, PMA, PENGELUARAN PEMERINTAH DAN TENAGA KERJA TERHADAP PERTUMBUHAN EKONOMI
Authors: Fiorentina Risma Fahrella , Ajeng Kartika Galuh
Published: September 2024

Central Java is a province on the island of Java that is experiencing relatively low economic growth. Even though Central Java Province has sufficient potential to support economic growth. Therefore, researchers in this study will identify whether there is influence of Foreign Investment, Domestic Investment, Workforce, and Government Expenditures on Economic Growth in Central Java. This research focuses on districts/cities in Central Java province. The data in this study were obtained from the Central Bureau of Statistics (BPS). To find out whether these variables affect economic growth in Central Java, panel data regression analysis is used. This research produces PMDN, Government Expenditures, and Labor which have a positive and significant effect on Economic Growth in Central Java.
Pengaruh Motivasi Intrinsik Dan Ekstrinsik Terhadap Kinerja Kantor Pelayanan Pajak
Authors: Ali Kamila , Irianto Gugus
Published: September 2024

Organizational performance reflects an organization's employee performance. As such, South Malang Small Tax Office achieved the progressive revenue target for the last three consecutive years from 2020 to 2022. This research aims to quantitatively analyze the effect of intrinsic and extrinsic motivations on employee performance, involving data collected from questionnaires distributed to 83 employees. This study exhibits that intrinsic and extrinsic motivations positively affect employee performance, which can be used as a reference to make strategies and decisions to improve performance and as a tool to evaluate employees through motivation.
Abstrak
Kinerja organisasi merupakan gambaran dari kinerja pegawai organisasi. Kantor Pelayanan Pajak (KPP) Malang Selatan dapat mencapai target penerimaan pajak selama tiga tahun terakhir dari 2020 hingga 2022. Bahkan ketika terdapat kenaikan target, KPP dapat merealisasikan. Penelitian ini memiliki tujuan untuk menguji pengaruh motivasi intrinsik dan ekstrinsik terhadap kinerja pegawai KPP Malang Selatan. Penelitian yang dilakukan termasuk penelitian kuantitatif dengan menggunakan metode pengumpulan data survey kuesioner. Sampel penelitian yang digunakan sebanyak 83 pegawai KPP Malang Selatan. Hasil penelitian menunjukkan bahwa motivasi intrinsik dan esktrinsik berpengaruh positif terhadap kinerja pegawai KPP Malang Selatan. Hasil penelitian dapat digunakan untuk perumusan strategi atau keputusan untuk meningkatkan kinerja dan evaluasi bagi para pegawai melalui motivasi.
Kardiovaskularni čimbenici rizika u bolesnika s teškim duševnim bolestima
Authors: Nadalin Sergej , Vučić Domagoj , Vilibić Maja , Peitl Vjekoslav , Maršić Luka , Dunđer Ivica , Cvitkušić Lukenda Katica , Karlović Dalibor
Published: September 2024

Bolesnici s teškim duševnim bolestima koje uključuju shizofreniju, veliki depresivni poremećaj i bipolarni afektivni poremećaj žive 15 – 25 godina kraće u odnosu na pripadnike opće populacije. Visoka stopa neprirodnih smrti (prvenstveno suicida) uvelike pridonosi skraćenom trajanju životnog vijeka u bolesnika s teškim duševnim bolestima. Kardiovaskularna oboljenja pokazala su se glavnim uzrokom prirodnih smrti u bolesnika s teškim duševnim bolestima, što je slično kao i u pripadnika opće populacije. Mnogi čimbenici rizika za kardiovaskularne bolesti u bolesnika s teškim duševnim bolestima, kao što su nezdrava prehrana, pušenje i nedovoljna tjelesna aktivnost, prisutni su i u pripadnika opće populacije. Dodatne čimbenike rizika kod bolesnika s teškim duševnim bolestima predstavljaju upotreba psihofarmaka te genetički čimbenici podložnosti, a riziku za kardiovaskularna oboljenja mogla bi pridonijeti i zanimljiva interakcija kardiovaskularnih čimbenika rizika. U znanstvenoj literaturi malo je sistemskih studija o kardiovaskularnim čimbenicima rizika u bolesnika s teškim duševnim bolestima, posebice o njihovoj interakciji. U kliničkoj su praksi komorbidne kardiovaskularne bolesti u bolesnika s teškim duševnim bolestima nerijetko nedovoljno prepoznate i liječene. U ovom radu iznesene su spoznaje o najvažnijim kardiovaskularnim čimbenicima rizika u bolesnika s teškim duševnim bolestima, pri čemu se ističe važnost multidisciplinarnog pristupa timova psihijatara i kardiologa u prevenciji kardiovaskularnih bolesti. Nadalje, iznesene su spoznaje o ulozi genetičkih čimbenika podložnosti za kardiovaskularne bolesti u bolesnika s teškim duševnim bolestima, s osvrtom na rezultate cjelogenomskih studija povezanosti. Konačno, raspravljaju se klinički značajne interakcije kardiovaskularnih lijekova i psihofarmaka te moguće neuropsihijatrijske nuspojave lijekova za kardiovaskularne bolesti.
Postupak zbrinjavanja adolescenata otrovanih ugljičnim monoksidom i njihovo liječenje u barokomori
Authors: Radošević Mia , Lah Tomulić Kristina
Published: September 2024

Cilj: Prikaz nenamjernog trovanja ugljičnim monoksidom adolescenata, čije zbrinjavanje još uvijek nije u potpunosti razrađeno te zahtijeva razvoj profesionalnog algoritma zbog učinkovite prevencije i pravovremenog liječenja. Detaljno je prikazana dijagnostika, kao i postupci zbrinjavanja akutnog trovanja ugljičnim monoksidom. Prikaz slučaja: 16-godišnji bolesnik zaprimljen je na odjel intenzivne njege zbog poremećaja svijesti nejasne etiologije. Heteroanamnestički se doznaje da je bolesnik pronađen u obiteljskoj kući bez svijesti. Bio je pothlađen uz drhtavicu i pjenu na ustima. Tijekom primarne obrade bolesnik je postavljen na monitoring vitalnih funkcija uz potporu kisikom na masku te parenteralnu hidraciju. Pri prijamu reagirao je jedino na bolni podražaj. Laboratorijski nalaz ukazivao je na kombiniranu acidozu, uz povišenu razinu karboksihemoglobina, zbog čega je nastavljena terapija 100-postotnim kisikom te je postavljena dijagnoza akutnog trovanja ugljičnim monoksidom. Iz laboratorijskih nalaza očitovala se povišena razina upalnih i bubrežnih parametara uz blago povišenu razinu laktata. Na radiogramu grudnih organa nije bilo znakova pneumotoraksa, ali su bili prisutni inicijalni znakovi respiratornog distresa. U svrhu liječenja bio je organiziran transport u barokomoru. Uz liječenje u barokomori te mnogobrojne suportivne mjere liječenja, pacijent je uspješno izliječen. Zaključak: Intoksikacija ugljičnim monoksidom predstavlja dijagnostički izazov te je i kod našeg bolesnika opisano opsežno i složeno liječenje. Faktori koji značajno pridonose smrtnosti jesu vrijeme proteklo od dolaska bolesnika na hitni prijam do početka liječenja te stanje u kojem pacijent pristiže na hitni prijam i koncentracija karboksihemoglobina u krvi pacijenta.
Neurološki simptom kao prvi znak kolorektalnog karcinoma
Authors: Dilber Ivo , Radovčić Gauta Ivana , Jajac Bručić Lana , Škifić Iva , Čulina Željko , Prejac Juraj
Published: September 2024

Aim: To present a rare case of a patient with an isolated brain metastasis from colorectal carcinoma in whom an extensive diagnostic workup failed to identify the primary tumour. Case report: A 73-year-old female patient was admitted to the Neurology Department due to weakness in the right side of her body. Imaging with multislice computed tomography (MSCT) and brain magnetic resonance (MR) confirmed an expansive lesion in the left frontal region with surrounding oedema. Radiological findings suggested either a metastasis or a high-grade primary glioma. As the diagnostic workup did not reveal the primary tumour, the patient was transferred to Clinical Hospital Dubrava for surgical treatment. An intracranial tumour resection was performed with a histopathological confirmation of colon carcinoma metastasis. Postoperative brain irradiation was administered. A positron emission tomography scan (PET) showed focal accumulation of radioisotopes without clear pathological substrate in the appendix and cecoascedent junction area. Repeated colonoscopy did not find any pathological mucosal changes. The patient declined systemic treatment. Overall survival was 11 months, in line with literature data. Conclusion: The diagnosis of brain metastases from colorectal carcinoma is very rare, and even rarer is the diagnosis of isolated brain metastases without extracranial progression, counting for <0.5%. Therapeutic options for brain metastases from colorectal carcinoma include surgery, radio-neurosurgery, stereotactic radiotherapy, and brain irradiation. In our opinion, diagnostic evaluation of the central nervous system in patients with colorectal carcinoma should be considered if the patient has neurological symptoms or if there is an increase in carcinoembryonic antigen (CEA) levels without signs of extracranial disease progression.
Toward Personalized Care and Patient Empowerment and Perspectives on a Personal Health Record in Hemophilia Care: Qualitative Interview Study
Authors: Brands Martijn R , Haverman Lotte , Muis Jelmer J , Driessens Mariëtte H E , Meijer Stephan , van der Meer Felix J M , de Jong Marianne , van der Bom Johanna G , Cnossen Marjon H , Fijnvandraat Karin , Gouw Samantha C
Published: September 2024

Background

To enable personalized treatment and shared decision-making in chronic care, relevant health information is collected. However, health information is often fragmented across hospital information systems, digital health apps, and questionnaire portals. This also pertains to hemophilia care, in which scattered information hampers integrated care. We intend to co-design a nationwide digital personal health record (PHR) for patients to help manage their health information. For this, user perspectives are crucial.

Objective

This study aims to assess patients’ and health care providers’ perspectives regarding the use of a PHR in hemophilia care in the Netherlands, required functionalities, and expectations and concerns.

Methods

In this semistructured interview study, 19 pediatric and adult persons with hemophilia, parents, and women with other inherited bleeding disorders, as well as 18 health care providers working within and outside of hemophilia treatment centers, participated. Perspectives of patients and providers were explored separately. To explore requirements, participants were asked to prioritize functionalities.

Results

Participants expected a PHR would increase the transparency of health information, improve patients’ understanding of their illness, and help the coordination of care between health care providers and institutions. Prioritized functionalities included the integration of relevant health information and patient-entered data. Formulated expectations and concerns focused on 4 themes: usability, safety, inclusiveness, and implementation. While patients expressed worries over medicalization (ie, more confrontational reminders of their illness), providers were concerned about an increased workload.

Conclusions

People with hemophilia, their parents, and health care providers welcomed the development of a PHR, as they expected it would result in better coordinated care. Formulated expectations and concerns will contribute to the successful development of a PHR for persons with hemophilia, and ultimately, for all persons with a chronic condition.
Role of Synchronous, Moderated, and Anonymous Peer Support Chats on Reducing Momentary Loneliness in Older Adults: Retrospective Observational Study
Authors: Dana Zara , Nagra Harpreet , Kilby Kimberly
Published: September 2024

Background

Older adults have a high rate of loneliness, which contributes to increased psychosocial risk, medical morbidity, and mortality. Digital emotional support interventions provide a convenient and rapid avenue for additional support. Digital peer support interventions for emotional struggles contrast the usual provider-based clinical care models because they offer more accessible, direct support for empowerment, highlighting the users’ autonomy, competence, and relatedness.

Objective

This study aims to examine a novel anonymous and synchronous peer-to-peer digital chat service facilitated by trained human moderators. The experience of a cohort of 699 adults aged ≥65 years was analyzed to determine (1) if participation, alone, led to measurable aggregate change in momentary loneliness and optimism and (2) the impact of peers on momentary loneliness and optimism.

Methods

Participants were each prompted with a single question: “What’s your struggle?” Using a proprietary artificial intelligence model, the free-text response automatched the respondent based on their self-expressed emotional struggle to peers and a chat moderator. Exchanged messages were analyzed to quantitatively measure the change in momentary loneliness and optimism using a third-party, public, natural language processing model (GPT-4 [OpenAI]). The sentiment change analysis was initially performed at the individual level and then averaged across all users with similar emotion types to produce a statistically significant (P<.05) collective trend per emotion. To evaluate the peer impact on momentary loneliness and optimism, we performed propensity matching to align the moderator+single user and moderator+small group chat cohorts and then compare the emotion trends between the matched cohorts.

Results

Loneliness and optimism trends significantly improved after 8 (P=.02) to 9 minutes (P=.03) into the chat. We observed a significant improvement in the momentary loneliness and optimism trends between the moderator+small group compared to the moderator+single user chat cohort after 19 (P=.049) and 21 minutes (P=.04) for optimism and loneliness, respectively.

Conclusions

Chat-based peer support may be a viable intervention to help address momentary loneliness in older adults and present an alternative to traditional care. The promising results support the need for further study to expand the evidence for such cost-effective options.
Implementation of Artificial Intelligence–Based Diabetic Retinopathy Screening in a Tertiary Care Hospital in Quebec: Prospective Validation Study
Authors: Antaki Fares , Hammana Imane , Tessier Marie-Catherine , Boucher Andrée , David Jetté Maud Laurence , Beauchemin Catherine , Hammamji Karim , Ong Ariel Yuhan , Rhéaume Marc-André , Gauthier Danny , Harissi-Dagher Mona , Keane Pearse A , Pomp Alfons
Published: September 2024

Background

Diabetic retinopathy (DR) affects about 25% of people with diabetes in Canada. Early detection of DR is essential for preventing vision loss.

Objective

We evaluated the real-world performance of an artificial intelligence (AI) system that analyzes fundus images for DR screening in a Quebec tertiary care center.

Methods

We prospectively recruited adult patients with diabetes at the Centre hospitalier de l’Université de Montréal (CHUM) in Montreal, Quebec, Canada. Patients underwent dual-pathway screening: first by the Computer Assisted Retinal Analysis (CARA) AI system (index test), then by standard ophthalmological examination (reference standard). We measured the AI system's sensitivity and specificity for detecting referable disease at the patient level, along with its performance for detecting any retinopathy and diabetic macular edema (DME) at the eye level, and potential cost savings.

Results

This study included 115 patients. CARA demonstrated a sensitivity of 87.5% (95% CI 71.9-95.0) and specificity of 66.2% (95% CI 54.3-76.3) for detecting referable disease at the patient level. For any retinopathy detection at the eye level, CARA showed 88.2% sensitivity (95% CI 76.6-94.5) and 71.4% specificity (95% CI 63.7-78.1). For DME detection, CARA had 100% sensitivity (95% CI 64.6-100) and 81.9% specificity (95% CI 75.6-86.8). Potential yearly savings from implementing CARA at the CHUM were estimated at CAD $245,635 (US $177,643.23, as of July 26, 2024) considering 5000 patients with diabetes.

Conclusions

Our study indicates that integrating a semiautomated AI system for DR screening demonstrates high sensitivity for detecting referable disease in a real-world setting. This system has the potential to improve screening efficiency and reduce costs at the CHUM, but more work is needed to validate it.
Research Hotspots and Trends of Virtual Reality Intervention for Stroke: A Bibliometric Analysis (Preprint)
Authors: Wei Yixin , Chen Yuan , Ma Runting , Qiu Yitong , Su Wei , Zhang Li , Gao Qiang
Published: September 2024

BACKGROUND

Virtual reality (VR) is a rapidly developing technology that has gained significant traction in the medical domain, particularly in the treatment and rehabilitation of individuals with stroke. The growing use of VR in stroke management has led to a notable increase in clinical investigations.

OBJECTIVE

The aim of this study is to present a bibliometric analysis of VR for stroke studies to identify prevailing research trends and guide future scientific research.

METHODS

Articles and reviews on the topic of virtual reality for stroke were retrieved from the Science Citation Index Expanded of Web of Science Core Collection database. The data related to publications, countries, institutions, authors, journals, citations, and keywords in the studies were systematically analyzed using VOSviewer 1.6.20 and Citespace 6.3.1 software.

RESULTS

A total of 1171 papers on the topic of VR for stroke between 1999 and 2023 were analyzed and visualized to identify research hotspots and trends in the field. The number of annual publications in this field of study has increased gradually over the past 20 years, with the number of annual publications peaking in 2022 (n=154). In terms of publications and total citations, countries, institutions, and authors from North America and Western Europe were found to make significant contributions to the field. The current hotspot is concentrated on evaluating the effectiveness of VR for improving upper limb and balance functions in stroke patients. The keyword analysis indicates that the latest research is oriented to investigate the effectiveness of VR in combination with rehabilitation techniques such as physiotherapy and occupational therapy for the treatment of stroke, and the advancements in VR technology are increasingly gaining focus.

CONCLUSIONS

Our study offers insights into the current hotspots and emerging trends of VR in the treatment of stroke. These findings may serve as a guide for future research and the application of VR for stroke.
On the Logic of Islamic Feminism: A case study of Minangkabaunese Matrilineality
Authors: Firdaus Qusthan Abqary Hisan
Published: September 2024

This article aims to seek (1) a new meaning of Islamic feminism and (2) its logical structure whether traditional or modern in its nature. I will examine Etin Anwar’s distinction between ‘Islamic feminism’ and ‘Muslim feminism’ and discuss the potential of self-ownership for developing arguments in favor of gender justice. While Anwar’s definition of Islamic feminism excludes male feminists in such a way, I argue that it is not strategic for gender justice, and it would be necessary to adopt self-ownership into the discourse of Islamic feminism instead. This suggestion manifests in the Minangkabau matrilineal setting, in which case men share their self-ownership with their wives, mothers, and sisters due to the institution of bundo kanduang. As a consequence, Minangkabaunese Muslim men shoulder some extra filial duties but enjoy nothing from the inheritance division. I also conducted several in-depth interviews with some experts concerning this issue. The upshot is that Islamic feminism should be inclusive of male feminists, and it should pay attention to the modern logic of dialetheia instead of the traditional logic.
EFIKASI PROFILAKSIS GRANISETRON 40 MCG/KGBB DIBANDINGKAN ONDANSETRON 8 MG DAN MEPERIDINE 0,4 MG/KGBB DALAM MENCEGAH SHIVERING PASKA ANESTESI SPINAL DI RSUP DR SARDJITO
Authors: Gentong Metia Gledis Gilang
Published: September 2024

Latar Belakang. Anestesi spinal mencetuskan hipotermia, yang mengakibatkan shivering dan menginduksi komplikasi pada pasien. Meperidine terbukti efektif mencegah shivering namun memiliki banyak efek samping. Antagonis 5-HT3 yaitu granisetron dan ondasetron diketahui dapat mencegah shivering dengan efek samping minimal ketika bekerja di pusat termoregulasi.
Tujuan. Mengetahui efikasi granisetron dibandingkan ondansetron dan meperidine dalam mencegah shivering paska anestesi spinal.
Metode Penelitian. Penelitian dengan uji klinis acak tersamar ganda terhadap 97 subyek pria/wanita, usia 18-65 tahun, status fisik ASA I dan II dengan operasi emergensi/ elektif di RSUP Dr. Sardjito Yogyakarta. Subjek dibagi dalam tiga kelompok. Granisetron 40 mcg/kgbb (kelompok G), Ondansetron 8 mg (kelompok O) dan Meperidine 0,4 mg/kgbb (kelompok M).
Hasil. Kelompok G menunjukan insidensi shivering sebanyak 10 subjek (31,3%), kelompok O sebanyak 15 subjek (45,5%) dan kelompok M sebanyak 10 subjek (31,3%) (p=0,386). Kelompok G menurunkan derajat keparahan shivering karena tidak terjadi shivering grade 3 dan 4 pada menit ke 60, dan lebih baik dibandingkan kelompok O yang menunjukan sebanyak 5 subjek (15,2%) mengalami shivering grade 3 dan 1 subjek (5%) mengalami shivering grade 4 (p=0,044).
Kesimpulan Profilaksis granisetron 40 mcg/kgbb sebelum spinal mengurangi keparahan shivering yang terjadi dibandingkan ondansetron 8 mg serta mengurangi insidensi shivering sama seperti meperidine 0,4 mg/kgbb dan ondansetron 8 mg.
Kata Kunci. Shivering, Anestesi Spinal, Granisetron, Ondansetron, Meperidine.
Innovations in the Ideological and Political Education Model for College Students under the Internet+ Background
Authors: Liu Dongya
Published: September 2024

Under the "Internet Plus" background, traditional ideological and political education for college students faces new challenges and opportunities. This paper aims to explore the impact of "Internet Plus" on ideological and political education and propose innovative educational models. The research methods include literature analysis, case studies, and empirical surveys. By analyzing the integration of existing educational models with emerging technologies, the study evaluates their effects and adaptability on ideological and political education. The main findings indicate that "Internet Plus" not only expands educational resources but also enhances student engagement and learning outcomes through interactive and personalized approaches. The conclusion highlights that the integration of internet technology offers new perspectives and methods for ideological and political education, promoting innovation and development in educational models.
DEPREDACIÓN DEL ANOLIS COMÚN, Anolis humilis, POR LA CHISBALA CENTROAMERICANA Holcosus festivus
Authors: Mora José Manuel , Matute Steven , Villalobos Alvarado Elián , Chaves Gerardo , López Lucía Isabel
Published: September 2024

En Costa Rica, hay 88 especies de lagartijas, incluidas especies de forrajeo activo como la chisbala centroamericana, Holcosus festivus, y cazadoras al acecho como el anolis común, Anolis humilis. Observamos un evento de depredación entre estas dos especies en la Estación Biológica La Selva, en las tierras bajas del norte de Costa Rica. Un juvenil de la chisbala capturó y consumió a un juvenil de anolis en el suelo de este bosque lluvioso. Los patrones de actividad principales del anolis común y de la chisbala probablemente conducen a encuentros frecuentes entre estas dos especies. A pesar de ello, sorprende que esta interacción depredadora no se haya observado ni informado anteriormente, y actualmente no está claro cuán a menudo o cuán significativos podrían ser los anolis para la dieta de la chisbala.
NUEVOS REGISTROS POR ATROPELLAMIENTO VEHICULAR PARA LA HERPETOFAUNA DEL MUNICIPIO DE RAFAEL DELGADO, VERACRUZ
Authors: Díaz García Juan Manuel
Published: September 2024

El atropellamiento de fauna silvestre por vehículos amenaza la biodiversidad global. En México, son reducidos los estudios sobre el impacto de los atropellamientos sobre las especies de anfibios y reptiles en comparación con otros países. En esta nota se presentan cuatro nuevos registros de especies de anfibios y reptiles en el municipio de Rafael Delgado, Veracruz, los cuales provienen de individuos atropellados por vehículos motorizados. Estos nuevos registros incrementan el conocimiento de la herpetofauna de Rafael Delgado, quedando representada actualmente por 11 especies de anfibios y 9 de reptiles.
Use of antibiotics among small-scale cattle farmers in rural areas in Queretaro, Mexico
Authors: Galarde-López Miguel , Cruz-Monsalvo Brenda Yoselin , Velazquez-Meza Maria Elena , Carranza-Velázquez José Alfredo , Zumaya-Estrada Federico Alonso , Carrillo-Quiroz Berta Alicia , Herrera-García Sara Claudia , Alpuche-Aranda Celia Mercedes
Published: September 2024

The inappropriate use of antibiotics in the livestock sector has been described as one of the causes of the emergence of antimicrobial resistance. Information on antibiotic use in small-scale farms is limited. Our objective was to identify patterns of antibiotic use in small-scale cattle farms in Queretaro, Mexico. Cross-sectional study with 50 small-scale cattle farmers from rural areas surveyed in the municipality of Tequisquiapan, Queretaro between May–October 2022. Convenience sampling, non-probabilistic, small-scale cattle farms were selected using respondent-driven sampling methodology. A face-to-face survey was applied, structured in five sections: i) small-scale cattle farmers´ profile, ii) characteristics of small-scale cattle farms, iii) antibiotic use, iv) antibiotic prescription, and v) inventory of stored antibiotics vials. The data collected were processed and analyzed. Ninety-two percent of the small-scale cattle farmers were male, with an age range of 23 to 88 years (median 58.5, IQR 49–64.5). Seventy-four percent of the small-scale cattle farmers had a basic level of schooling. The animal census consisted of 968 animals. A total of 142 stored antibacterial products from nine antibiotic classes were recorded: 34.5 % were penicillin, 19 % oxytetracycline, 13.4 % gentamicin, 9.8 % florfenicol, and 8.4 %enrofloxacin. About 50 % of the stored antibiotics have a "watch" classification in the WHO AWaRe tool. Seventy-eight percent of small-scale cattle farmers throw empty antibiotic vials in the trash. Our study showed that small-scale cattle farmers had an important use of third generation cephalosporins, tetracyclines, and fluoroquinolones; antibiotics considered “watch” by the WHO.
Stock Market Prediction Using Fuzzy Logic and Technical Indicators: A Case Study of Indian Banks
Authors: Yandamuri Dr. Swathi
Published: September 2024

This study presents a decision support system for stock market investors that combines technical analysis with fuzzy logic. The system utilizes four essential technical indicators—Moving Average Convergence/Divergence (MACD), Relative Strength Index (RSI), Stochastic Oscillator (SO), and On-Balance Volume (OBV)—to predict future price movements. These indicators are mapped as inputs into a fuzzy inference system, where fuzzy rules and membership functions are applied to generate trading recommendations, categorized as Bullish, Neutral, or Bearish. Experiments using MATLAB with data from 10 Indian banks demonstrate that the system effectively predicts stock movements and improves investment decisions when integrated with additional market information and investor insights
Entanglement buffering with two quantum memories
Authors: Davies Bethany , Iñesta Álvaro G. , Wehner Stephanie
Published: September 2024

Quantum networks crucially rely on the availability of high-quality entangled pairs of qubits, known as entangled links, distributed across distant nodes. Maintaining the quality of these links is a challenging task due to the presence of time-dependent noise, also known as decoherence. Entanglement purification protocols offer a solution by converting multiple low-quality entangled states into a smaller number of higher-quality ones. In this work, we introduce a framework to analyse the performance of entanglement buffering setups that combine entanglement consumption, decoherence, and entanglement purification. We propose two key metrics: the availability, which is the steady-state probability that an entangled link is present, and the average consumed fidelity, which quantifies the steady-state quality of consumed links. We then investigate a two-node system, where each node possesses two quantum memories: one for long-term entanglement storage, and another for entanglement generation. We model this setup as a continuous-time stochastic process and derive analytical expressions for the performance metrics. Our findings unveil a trade-off between the availability and the average consumed fidelity. We also bound these performance metrics for a buffering system that employs the well-known bilocal Clifford purification protocols. Importantly, our analysis demonstrates that, in the presence of noise, consistently purifying the buffered entanglement increases the average consumed fidelity, even when some buffered entanglement is discarded due to purification failures.
THE EMERGING FUTURE OF AI CHATBOTS IN HIGHER EDUCATION
Authors: Sain Zohaib Hassan , Vasudevan Asokan , Lama Alma Vorfi
Published: September 2024

Incorporating Artificial Intelligence (AI) chatbots within Higher Education Institutions (HEIs) is revolutionizing the educational domain, presenting new avenues for improved student support and administrative effectiveness. This research delves into the prospective impacts of AI chatbots in HEIs, focusing on their influence on teaching, learning, and research activities. Adopting a Narrative Literature Review (NLR) approach, the study compiles and synthesizes existing research on the role of AI chatbots in higher education, drawing from a wide range of academic sources and scholarly literature. The results underscore the significant potential of AI chatbots to streamline administrative functions, enrich student learning experiences, and facilitate research endeavours. Nonetheless, challenges such as concerns over academic integrity, difficulties in accurately interpreting user inputs, and the need for appropriate resource allocation present substantial barriers to the successful adoption of AI chatbots in HEIs. The study emphasizes the critical need for proactive strategies to address ethical issues, ensure comprehensive training for all stakeholders, and formulate clear guidelines for the responsible deployment of AI chatbots in higher education. By overcoming these challenges and capitalizing on the advantages of AI technologies, HEIs can fully exploit the capabilities of AI chatbots, thereby fostering a more efficient, effective, inclusive, and forward-thinking educational environment.
PHILOSOPHICAL VALUES IN NUMBER THEORY OF IKHWĀN AL-ṢAFĀ'
Authors: Walid Kholid Al , Miri Mohsen , Rijal Syamsul , Lestari Ayu , Norman Nurul Ain
Published: September 2024

In mathematics, especially Arithmetic, there is a theory of numbers that can represent philosophical values. Mathematics is often presented with materialist values without deep meaning. One group of classical philosophers with mathematical thoughts, especially number theory, which explains the number material itself and relates it to meaningful philosophical values, is Ikhwān al-Ṣafā'. This research aims to reveal the philosophical values contained in the thought of the number. Using a qualitative research method based on a literature study approach, the researcher specifically examines the phenomenal book Rasā'il Ikhwān al-Ṣafā' as a primary source as well as other relevant references as secondary sources. The study found that in the number theory of Ikhwān al-Ṣafā', there are philosophical values such as monotheism described by the characteristics of the number one and the value of creation described by the sequence of the number ladder. This research initiates a discourse on the philosophy of numbers that previously has never been studied for it will serve as a pioneer for further research.
MĪRĀTH ALMTḤWL JNSYAN DIRĀSAH FIQHĪYAH QĀNŪNĪYAH
Authors: Hammad Hamza Abed Alkarim
Published: September 2024

The aim of this study is discussing the contemporary Fiqh views on the impact of sex change on transgender inheritance and discuss them. The study followed the comparative critical inductive approach. The study ended up dividing the impact of sex change on transgender inheritance into two forms; the first: if the transgender is the inheritor, then his share is the share of the hermaphrodite formed according to the Hanafi school; to activate the principle of Ta'zir by taking money, and the position of Hanafi is necessary for the Jordanian Personal Status Law. If the transferee is the inheritor, there is no effect of the transferee on the share of the heirs.
UNRAVELING THE INFLUENCE OF BUILDING MATERIALS CRITERIA (BMC) ON HOTEL’S OPERATIONAL SUSTAINABILITY
Authors: Ismail Nur Adlina , Khalil Natasha , Sani Suwaibatul Islamiah Abdullah
Published: September 2024

The core business of hotels lies in the hotel buildings design and its service operation. As the hotels are concentrating more on aesthetics values as one aspect of perceived experiential value, a careful selection of materials is urgently needed for hotel sectors. It is important to identify the crucial criteria in choosing building materials towards the hotel’s operational sustainability. Thus, this paper aims to analyze the significance level building materials criteria (BMC) towards hotel’s operational sustainability. A quantitative approach was adopted via questionnaire surveys to 116 operation and maintenance manager that worked in 29 green rated hotels throughout Malaysia. The data is analysed using SmartPLS 4, a software with graphical user interface for variance-based structural equation modeling (SEM) using the partial least squares (PLS) path modeling method. Results from the SEM-PLS has supported three (3) hypothesis, that confirmed the manufacturers criteria, health criteria and resource management criteria, as the BMC variables has significance relationship towards hotel’s operational sustainability. This study significantly helps the developers, hoteliers, stakeholders, consultants, and designers to be aware of the applicability and suitability to be used in their projects. The findings provide practical insights for hotel operators and managers, offering guidance on selecting building materials aligned with sustainability goals. This operational focus can aid hotels in making informed decisions that enhance their overall sustainability performance.
A new generalization of min and max matrices and their reciprocals counterparts
Authors: da Fonseca Carlos , Kızılateş Can , Terzioğlu Nazlıhan
Published: September 2024

In this paper, we introduce a new generalization of the min and max matrices
called geometric min matrix and geometric max matrix, respectively. We
discuss some of their properties, such as determinants, inverses,
factorizations, and identities for their characteristic polynomials.
Moreover, their reciprocal analogs for these newly established matrices are
examined.
Existence results for non-instantaneous impulsive Riemann-Liouville fractional stochastic differential equations with delay
Authors: Arioui Fatima
Published: September 2024

In this paper, we investigate a fractional stochastic differential equation
with delay and noninstantaneous impulses involving the Riemann-Liouville
derivative of order ? ? (1/2, 1) with a fixed lower bound. The integral
representation of the mild solution is presented, and existence results are
established using Banach?s fixed point theorem under appropriate
assumptions. An example is provided to illustrate the main result.
Three-dimensional assessment of the nasopharyngeal airway in Down syndrome during the mixed dentition period: a case-control study
Authors: Takizawa Hideomi , Takahashi Masahiro , Yoshida Hiroshi , Yamaguchi Tetsutaro , Maki Koutaro
Published: September 2024

Objective

In this retrospective case-control study, we aimed to evaluate the nasopharyngeal airway volume of children with Down syndrome (DS) and compare the results with those of control participants well matched for sex and age.

Materials and Methods

Fifteen children with DS (mean age = 9.43 ± 0.38 years; 8 boys, 7 girls) and 15 control participants (mean age = 9.51 ± 0.40 years; 8 boys, 7 girls) were enrolled. The nasopharyngeal airway volume and the cross-sectional morphology were measured with cone-beam computed tomography taken for orthodontic treatment. All measurements were assessed by analysis of covariance (ANCOVA) using Bonferroni post hoc pairwise comparison tests. Covariates were body height and body weight, and the ANB angle and the mandibular plane angle. Significance was set at P < .0019.

Results

Nasal airway, superior airway, and total airway volumes of DS participants were significantly smaller than those of the control participants in ANCOVA results adjusted for ANB angle and mandibular plane angle (P = .000). In ANCOVA results adjusted for body height and body weight, no statistically significant differences in the volume measurements were found.

Conclusion

The results indicate that the nasopharyngeal airway volume differs between children with and without DS and that the airway volume tends to be smaller in DS children than in children without DS.