bluuebunny/crossref_metadata_2025 huggingface dataset:
Kinase-independent role for CRAF-driving tumour radioresistance via CHK2
Authors: Advani Sunil J. , Camargo Maria Fernanda , Seguin Laetitia , Mielgo Ainhoa , Anand Sudarshan , Hicks Angel M. , Aguilera Joseph , Franovic Aleksandra , Weis Sara M. , Cheresh David A.
Published: September 2015

Although oncology therapy regimens commonly include radiation and genotoxic drugs, tumour cells typically develop resistance to these interventions. Here we report that treatment of tumours with ionizing radiation or genotoxic drugs drives p21-activated kinase 1 (PAK1)-mediated phosphorylation of CRAF on Serine 338 (pS338) triggering a kinase-independent mechanism of DNA repair and therapeutic resistance. CRAF pS338 recruits CHK2, a cell cycle checkpoint kinase involved in DNA repair, and promotes CHK2 phosphorylation/activation to enhance the tumour cell DNA damage response. Accordingly, a phospho-mimetic mutant of CRAF (S338D) is sufficient to induce the CRAF/CHK2 association enhancing tumour radioresistance, while an allosteric CRAF inhibitor sensitizes tumour cells to ionizing radiation or genotoxic drugs. Our findings establish a role for CRAF in the DNA damage response that is independent from its canonical function as a kinase.
Activity-regulated trafficking of the palmitoyl-acyl transferase DHHC5
Authors: Brigidi G. Stefano , Santyr Brendan , Shimell Jordan , Jovellar Blair , Bamji Shernaz X.
Published: September 2015

Synaptic plasticity is mediated by the dynamic localization of proteins to and from synapses. This is controlled, in part, through activity-induced palmitoylation of synaptic proteins. Here we report that the ability of the palmitoyl-acyl transferase, DHHC5, to palmitoylate substrates in an activity-dependent manner is dependent on changes in its subcellular localization. Under basal conditions, DHHC5 is bound to PSD-95 and Fyn kinase, and is stabilized at the synaptic membrane through Fyn-mediated phosphorylation of a tyrosine residue within the endocytic motif of DHHC5. In contrast, DHHC5’s substrate, δ-catenin, is highly localized to dendritic shafts, resulting in the segregation of the enzyme/substrate pair. Neuronal activity disrupts DHHC5/PSD-95/Fyn kinase complexes, enhancing DHHC5 endocytosis, its translocation to dendritic shafts and its association with δ-catenin. Following DHHC5-mediated palmitoylation of δ-catenin, DHHC5 and δ-catenin are trafficked together back into spines where δ-catenin increases cadherin stabilization and recruitment of AMPA receptors to the synaptic membrane.
Monomeric C-reactive protein-a key molecule driving development of Alzheimer’s disease associated with brain ischaemia?
Authors: Slevin M. , Matou S. , Zeinolabediny Y. , Corpas R. , Weston R. , Liu D. , Boras E. , Di Napoli M. , Petcu E. , Sarroca S. , Popa-Wagner A. , Love S. , Font M. A. , Potempa L. A. , Al-baradie R. , Sanfeliu C. , Revilla S. , Badimon L. , Krupinski J.
Published: September 2015

Alzheimer’s disease (AD) increases dramatically in patients with ischaemic stroke. Monomeric C-reactive protein (mCRP) appears in the ECM of ischaemic tissue after stroke, associating with microvasculature, neurons and AD-plaques, Aβ, also, being able to dissociate native-CRP into inflammatory, mCRP in vivo. Here, mCRP injected into the hippocampal region of mice was retained within the retrosplenial tract of the dorsal 3rd ventrical and surrounding major vessels. Mice developed behavioural/cognitive deficits within 1 month, concomitant with mCRP staining within abnormal looking neurons expressing p-tau and in beta-amyloid 1-42-plaque positive regions. mCRP co-localised with CD105 in microvessels suggesting angiogenesis. Phospho-arrays/Western blotting identified signalling activation in endothelial cells and neurons through p-IRS-1, p-Tau and p-ERK1/2-which was blocked following pre-incubation with mCRP-antibody. mCRP increased vascular monolayer permeability and gap junctions, increased NCAM expression and produced haemorrhagic angiogenesis in mouse matrigel implants. mCRP induced tau244–372 aggregation and assembly in vitro. IHC study of human AD/stroke patients revealed co-localization of mCRP with Aβ plaques, tau-like fibrils and IRS-1/P-Tau positive neurons and high mCRP-levels spreading from infarcted core regions matched reduced expression of Aβ/Tau. mCRP may be responsible for promoting dementia after ischaemia and mCRP clearance could inform therapeutic avenues to reduce the risk of future dementia.
Boron-rich benzene and pyrene derivatives for the detection of thermal neutrons
Authors: Yemam Henok A. , Mahl Adam , Koldemir Unsal , Remedes Tyler , Parkin Sean , Greife Uwe , Sellinger Alan
Published: September 2015

A synthetic methodology is developed to generate boron rich aromatic small molecules based on benzene and pyrene moieties for the detection of thermal neutrons. The prepared aromatic compounds have a relatively high boron content up to 7.4 wt%, which is important for application in neutron detection as 10B (20% of natural abundance boron) has a large neutron induced reaction cross-section. This is demonstrated by preparing blends of the synthesized molecules with fluorescent dopants in poly(vinyltoluene) matrices resulting in comparable scintillation light output and neutron capture as state-of-the art commercial scintillators, but with the advantage of much lower cost. The boron-rich benzene and pyrene derivatives are prepared by Suzuki conditions using both microwave and traditional heating, affording yields of 40–93%. This new procedure is simple and straightforward and has the potential to be scaled up.
Generalized Kirchhoff-Law-Johnson-Noise (KLJN) secure key exchange system using arbitrary resistors
Authors: Vadai Gergely , Mingesz Robert , Gingl Zoltan
Published: September 2015

The Kirchhoff-Law-Johnson-Noise (KLJN) secure key exchange system has been introduced as a simple, very low cost and efficient classical physical alternative to quantum key distribution systems. The ideal system uses only a few electronic components—identical resistor pairs, switches and interconnecting wires—in order to guarantee perfectly protected data transmission. We show that a generalized KLJN system can provide unconditional security even if it is used with significantly less limitations. The more universal conditions ease practical realizations considerably and support more robust protection against attacks. Our theoretical results are confirmed by numerical simulations.
Comparative Proteomics Analyses of Two Races of Fusarium oxysporum f. sp. conglutinans that Differ in Pathogenicity
Authors: Li Erfeng , Ling Jian , Wang Gang , Xiao Jiling , Yang Yuhong , Mao Zhenchuan , Wang Xuchu , Xie Bingyan
Published: September 2015

Fusarium oxysporum is a soil-inhabiting fungus that induces vascular wilt and root rot in a variety of plants. F. oxysporum f. sp. conglutinans (Foc), which comprises two races, can cause wilt disease in cabbage. Compared with race 1 (52557−TM, R1), race 2 (58385−TM, R2) exhibits much stronger pathogenicity. Here, we provide the first proteome reference maps for Foc mycelium and conidia and identify 145 proteins with different abundances among the two races. Of these proteins, most of the high-abundance proteins in the R2 mycelium and conidia are involved in carbohydrate, amino acid and ion metabolism, which indicates that these proteins may play important roles in isolate R2’s stronger pathogenicity. The expression levels of 20 typical genes demonstrate similarly altered patterns compared to the proteomic analysis. The protein glucanosyltransferase, which is involved in carbohydrate metabolism, was selected for research. We knocked out the corresponding gene (gas1) and found that Foc-∆gas1 significantly reduced growth rate and virulence compared with wild type isolates. These results deepened our understanding of the proteins related to F. oxysporum pathogenicity in cabbage Fusarium wilt and provided new opportunities to control this disease.
Ice-templated Self-assembly of VOPO4–Graphene Nanocomposites for Vertically Porous 3D Supercapacitor Electrodes
Authors: Lee Kwang Hoon , Lee Young-Woo , Lee Seung Woo , Ha Jeong Sook , Lee Sang-Soo , Son Jeong Gon
Published: September 2015

A simple ice-templated self-assembly process is used to prepare a three-dimensional (3D) and vertically porous nanocomposite of layered vanadium phosphates (VOPO4) and graphene nanosheets with high surface area and high electrical conductivity. The resulting 3D VOPO4–graphene nanocomposite has a much higher capacitance of 527.9 F g−1 at a current density of 0.5 A g−1, compared with ~247 F g−1 of simple 3D VOPO4, with solid cycling stability. The enhanced pseudocapacitive behavior mainly originates from vertically porous structures from directionally grown ice crystals and simultaneously inducing radial segregation and forming inter-stacked structures of VOPO4–graphene nanosheets. This VOPO4–graphene nanocomposite electrode exhibits high surface area, vertically porous structure to the separator, structural stability from interstacked structure and high electrical conductivity, which would provide the short diffusion paths of electrolyte ions and fast transportation of charges within the conductive frameworks. In addition, an asymmetric supercapacitor (ASC) is fabricated by using vertically porous VOPO4–graphene as the positive electrode and vertically porous 3D graphene as the negative electrode; it exhibits a wide cell voltage of 1.6 V and a largely enhanced energy density of 108 Wh kg−1.
An information-theoretic model for link prediction in complex networks
Authors: Zhu Boyao , Xia Yongxiang
Published: September 2015

Various structural features of networks have been applied to develop link prediction methods. However, because different features highlight different aspects of network structural properties, it is very difficult to benefit from all of the features that might be available. In this paper, we investigate the role of network topology in predicting missing links from the perspective of information theory. In this way, the contributions of different structural features to link prediction are measured in terms of their values of information. Then, an information-theoretic model is proposed that is applicable to multiple structural features. Furthermore, we design a novel link prediction index, called Neighbor Set Information (NSI), based on the information-theoretic model. According to our experimental results, the NSI index performs well in real-world networks, compared with other typical proximity indices.
Antiferromagnetic Spin Coupling between Rare Earth Adatoms and Iron Islands Probed by Spin-Polarized Tunneling
Authors: Coffey David , Diez-Ferrer José Luis , Serrate David , Ciria Miguel , Fuente César de la , Arnaudas José Ignacio
Published: September 2015

High-density magnetic storage or quantum computing could be achieved using small magnets with large magnetic anisotropy, a requirement that rare-earth iron alloys fulfill in bulk. This compelling property demands a thorough investigation of the magnetism in low dimensional rare-earth iron structures. Here, we report on the magnetic coupling between 4f single atoms and a 3d magnetic nanoisland. Thulium and lutetium adatoms deposited on iron monolayer islands pseudomorphically grown on W(110) have been investigated at low temperature with scanning tunneling microscopy and spectroscopy. The spin-polarized current indicates that both kind of adatoms have in-plane magnetic moments, which couple antiferromagnetically with their underlying iron islands. Our first-principles calculations explain the observed behavior, predicting an antiparallel coupling of the induced 5d electrons magnetic moment of the lanthanides with the 3d magnetic moment of iron, as well as their in-plane orientation and pointing to a non-contribution of 4f electrons to the spin-polarized tunneling processes in rare earths.
K-factor image deshadowing for three-dimensional fluorescence microscopy
Authors: Ilovitsh Tali , Weiss Aryeh , Meiri Amihai , Ebeling Carl G. , Amiel Aliza , Katz Hila , Mannasse-Green Batya , Zalevsky Zeev
Published: September 2015

The ability to track single fluorescent particles within a three dimensional (3D) cellular environment can provide valuable insights into cellular processes. In this paper, we present a modified nonlinear image decomposition technique called K-factor that reshapes the 3D point spread function (PSF) of an XYZ image stack into a narrow Gaussian profile. The method increases localization accuracy by ~60% with compare to regular Gaussian fitting and improves minimal resolvable distance between overlapping PSFs by ~50%. The algorithm was tested both on simulated data and experimentally.
The Optimized Fabrication of Nanobubbles as Ultrasound Contrast Agents for Tumor Imaging
Authors: Cai Wen Bin , Yang Heng Li , Zhang Jian , Yin Ji Kai , Yang Yi Lin , Yuan Li Jun , Zhang Li , Duan Yun You
Published: September 2015

Nanobubbles, which have the potential for ultrasonic targeted imaging and treatment in tumors, have been a research focus in recent years. With the current methods, however, the prepared uniformly sized nanobubbles either undergo post-formulation manipulation, such as centrifugation, after the mixture of microbubbles and nanobubbles, or require the addition of amphiphilic surfactants. These processes influence the nanobubble stability, possibly create material waste and complicate the preparation process. In the present work, we directly prepared uniformly sized nanobubbles by modulating the thickness of a phospholipid film without the purification processes or the addition of amphiphilic surfactants. The fabricated nanobubbles from the optimal phospholipid film thickness exhibited optimal physical characteristics, such as uniform bubble size, good stability and low toxicity. We also evaluated the enhanced imaging ability of the nanobubbles both in vitro and in vivo. The in vivo enhancement intensity in the tumor was stronger than that of SonoVue after injection (UCA; 2 min: 162.47 ± 8.94 dB vs. 132.11 ± 5.16 dB, P < 0.01; 5 min: 128.38.47 ± 5.06 dB vs. 68.24 ± 2.07 dB, P < 0.01). Thus, the optimal phospholipid film thickness can lead to nanobubbles that are effective for tumor imaging.
The novel ABC transporter ABCH1 is a potential target for RNAi-based insect pest control and resistance management
Authors: Guo Zhaojiang , Kang Shi , Zhu Xun , Xia Jixing , Wu Qingjun , Wang Shaoli , Xie Wen , Zhang Youjun
Published: September 2015

Insect pests cause serious crop damage and develop high-level resistance to chemical insecticides andBacillus thuringiensis(Bt) insecticidal Cry toxins. A new promising approach for controlling them and overcoming this resistance is RNA interference (RNAi). The RNAi-based insect control strategy depends on the selection of suitable target genes. In this study, we cloned and characterized a novel ABC transporter genePxABCH1in diamondback moth,Plutella xylostella(L.). Phylogenetic analysis showed thatPxABCH1is closely related to ABCA and ABCG subfamily members. Spatial-temporal expression detection revealed thatPxABCH1was expressed in all tissues and developmental stages and highest expressed in head and male adult. Midgut sequence variation and expression analyses ofPxABCH1in all the susceptible and Bt-resistantP. xylostellastrains and the functional analysis by sublethal RNAi demonstrated that Cry1Ac resistance was independent of this gene. Silencing ofPxABCH1by a relatively high dose of dsRNA dramatically reduced its expression and resulted in larval and pupal lethal phenotypes in both susceptible and Cry1Ac-resistantP. xylostellastrains. To our knowledge, this study provides the first insight into ABCH1 in lepidopterans and reveals it as an excellent target for RNAi-based insect pest control and resistance management.
Identification of outliers in a genomic scan for selection along environmental gradients in the bamboo locust, Ceracris kiangsu
Authors: Feng Xiao-Jing , Jiang Guo-Fang , Fan Zhou
Published: September 2015

Identification of loci under divergent selection is a key step in understanding the evolutionary process because those loci are responsible for the genetic variations that affect fitness in different environments. Understanding how environmental forces give rise to adaptive genetic variation is a challenge in pest control. Here, we performed an amplified fragment length polymorphism (AFLP) genome scan in populations of the bamboo locust, Ceracris kiangsu, to search for candidate loci that are influenced by selection along an environmental gradient in southern China. In outlier locus detection, loci that demonstrate significantly higher or lower among-population genetic differentiation than expected under neutrality are identified as outliers. We used several outlier detection methods to study the features of C. kiangsu, including method DFDIST, BayeScan and logistic regression. A total of 97 outlier loci were detected in the C. kiangsu genome with very high statistical supports. Moreover, the results suggested that divergent selection arising from environmental variation has been driven by differences in temperature, precipitation, humidity and sunshine. These findings illustrate that divergent selection and potential local adaptation are prevalent in locusts despite seemingly high levels of gene flow. Thus, we propose that native environments in each population may induce divergent natural selection.
Intermediates in the cation reactions in solution probed by an in situ surface enhanced Raman scattering method
Authors: Tan Chih-Shan , Chen Hung-Ying , Chen Hsueh-Szu , Gwo Shangjr , Chen Lih-Juann
Published: September 2015

For chemical reactions in liquid state, such as catalysis, understanding of dynamical changes is conducive to practical applications. Solvation of copper salts in aqueous solution has implications for life, the environment and industry. In an ongoing research, the question arises that why the color of aqueous CuCl2 solution changes with solution concentration? In this work, we have developed a convenient and efficient in situ surface enhanced Raman scattering technique to probe the presence of many intermediates, some of them are responsible for color change, in crystallization of aqueous copper chloride solution. The versatility of the novel technique was confirmed in the identification of five intermediates states in the transition from CdS to MoS2 nanowires in solution. The facile in situ method is expected to be widely applicable in probing intermediate states in a variety of chemical reactions in solution.
Polydimethylsiloxane SlipChip for mammalian cell culture applications
Authors: Chang Chia-Wen , Peng Chien-Chung , Liao Wei-Hao , Tung Yi-Chung
Published: September 2015

A polydimethylsiloxane (PDMS) SlipChip for in vitro mammalian cell culture applications, including multiple-treatment assays, cell co-culture, and cytokine detection assays.
A how-to approach for estimation of surface/Stern potentials considering ionic size and polarization
Authors: Liu Xinmin , Hu Feinan , Ding Wuquan , Tian Rui , Li Rui , Li Hang
Published: September 2015

Based on the effects of ionic volume in Stern layer and polarization in diffuse layer, the relationship between surface potential and Stern potential is quantified.
Gold nanoparticle-catalyzed uranine reduction for signal amplification in fluorescent assays for melamine and aflatoxin B1
Authors: Wang Xu , Pauli Jutta , Niessner Reinhard , Resch-Genger Ute , Knopp Dietmar
Published: September 2015

A multifunctional fluorescence platform has been constructed based on gold nanoparticle (AuNP)-catalyzed uranine reduction.
A label-free and sensitive electrochemical aptasensor for thrombin based on the direct electron transfer of hemin and hemin@rGO nanosheets as the signal probe
Authors: Xue Shuyan , Yi Huafyu , Yuan Yali , Jing Pei , Xu Wenju
Published: September 2015

In this work, a label-free electrochemical aptasensor for sensitive detection of thrombin was fabricated and characterized.
A self-assembled nanotube for the direct aldol reaction in water
Authors: Lee Kwang Soo , Parquette Jon R.
Published: September 2015

The self-assembly of a low weight, dipeptide into well-defined nanotubes that catalyze the direct aldol reaction in water is reported.
Access to pure and highly volatile hydrochalcogenide ionic liquids
Authors: Finger L. H. , Wohde F. , Grigoryev E. I. , Hansmann A.-K. , Berger R. , Roling B. , Sundermeyer J.
Published: September 2015

The reaction of H2S with methylcarbonate salts allows access to pure hydrosulphide ILs, which show an astoundingly high volatility below 100 °C allowing high-end purification and ionic single crystal growth by sublimation.
Towards the tailored design of benzotriazinyl-based organic radicals displaying a spin transition
Authors: Fumanal M. , Vela S. , Novoa J. J. , Ribas-Arino J.
Published: September 2015

In this work, we identify the ingredients that are crucial to enable the phase transition in benzotriazinyl-based organic radicals.
Identification of key residues in Debaryomyces hansenii carbonyl reductase for highly productive preparation of (S)-aryl halohydrins
Authors: Xu Guo-Chao , Shang Yue-Peng , Yu Hui-Lei , Xu Jian-He
Published: September 2015

Key residues were identified through combinatorial mutation of conserved residues with notably improved productivity in asymmetric reduction of α-chloroacetophenone.
In situ variable-temperature single crystal X-ray diffraction studies of the single-crystal-to-single-crystal dehydration and rehydration of a mixed-ligand 2D zinc metal–organic framework using trimesate and 4,4′-bipyridine-N,N′-dioxide as ligands
Authors: Tahier Tayyibah , Oliver Clive L.
Published: September 2015

A mixed-ligand 2D MOF based on ZnSO4, trimesate and 4,4′-bipyridine-N,N′-dioxide shows reversible loss of uncoordinated and coordinated water molecules.
Multipole-preserving quadratures for the discretization of functions in real-space electronic structure calculations
Authors: Genovese Luigi , Deutsch Thierry
Published: September 2015

Discretizing an analytic function on a uniform real-space grid is often done via a straightforward collocation method.
Protein docking using an ensemble of spin labels optimized by intra-molecular paramagnetic relaxation enhancement
Authors: Schilder Jesika , Liu Wei-Min , Kumar Pravin , Overhand Mark , Huber Martina , Ubbink Marcellus
Published: September 2015

The effect of spin label mobility on the accuracy of protein–protein docking calculations was investigated using inter- and intra-molecular PRE data.
Cluster-continuum quasichemical theory calculation of the lithium ion solvation in water, acetonitrile and dimethyl sulfoxide: an absolute single-ion solvation free energy scale
Authors: Carvalho Nathalia F. , Pliego Josefredo R.
Published: September 2015

A solvation free energy scale excluding the net electrostatic potential inside the solute cavity is presented.
Is there an intramolecular hydrogen bond in 2-halophenols? A theoretical and spectroscopic investigation
Authors: Abraham Michael H. , Abraham Raymond J. , Aliev Abil E. , Tormena Claudio F.
Published: September 2015

H-bonding is the most important interaction in life. We present a theoretical and spectroscopic investigation of intramolecular H-bonding in 2-halophenols.
On the performance of FAU and MFI zeolites for the adsorptive removal of a series of volatile organic compounds from air using molecular simulation
Authors: Calero S. , Gómez-Álvarez P.
Published: September 2015

Importance of zeolite pore size and topology for the adsorptive-based recovery of volatile organic compounds.
100 fs photo-isomerization with vibrational coherences but low quantum yield in Anabaena Sensory Rhodopsin
Authors: Cheminal Alexandre , Léonard Jérémie , Kim So-Young , Jung Kwang-Hwan , Kandori Hideki , Haacke Stefan
Published: September 2015

Counter-intuitive photochemistry: in Anabaena Sensory Rhodopsin, the retinal 13-cis isomer isomerizes much faster than all-trans ASR, but with a 3-times lower quantum yield.
Elementary photocatalytic chemistry on TiO2surfaces
Authors: Guo Qing , Zhou Chuanyao , Ma Zhibo , Ren Zefeng , Fan Hongjun , Yang Xueming
Published: September 2015

In this article, we review the recent advances in the photoreactions of small molecules with model TiO2surfaces, and propose a photocatalytical model based on nonadiabatic dynamics and ground state surface reactions.
Fluorescence based explosive detection: from mechanisms to sensory materials
Authors: Sun Xiangcheng , Wang Ying , Lei Yu
Published: September 2015

The state-of-the-art of fluorescent materials and their sensing mechanism/properties for the detection of explosives in the recent 5 years were systematically reviewed.
Catalytic defluorinative [3 + 2] cycloaddition of trifluoromethylalkenes with alkynes via reduction of nickel(ii) fluoride species
Authors: Fujita Takeshi , Arita Tomohiro , Ichitsuka Tomohiro , Ichikawa Junji
Published: September 2015

A catalytic synthesis of 2-fluoro-1,3-cyclopentadienes was achieved via [3 + 2] cycloaddition of 2-trifluoromethyl-1-alkenes and alkynes using a nickel catalyst and a diboron-based ternary additive system.
Dissolved organic matter in Lake Superior: insights into the effects of extraction methods on chemical composition
Authors: Li Hongyu , Minor Elizabeth C.
Published: September 2015

The SPE resin choice (C18 vs. SDB-XC) affects the chemical composition of the resulting extract but differences between near and offshore dissolved organic matter samples remain clear.
Influence of bio-based solvents on the catalytic reductive fractionation of birch wood
Authors: Schutyser W. , Van den Bosch S. , Renders T. , De Boe T. , Koelewijn S.-F. , Dewaele A. , Ennaert T. , Verkinderen O. , Goderis B. , Courtin C. M. , Sels B. F.
Published: September 2015

In the reductive catalytic fractionation of lignocellulose, the choice of solvent significantly impacts the delignification efficiency, carbohydrate retention in the pulp and the macrostructure of the pulp.
Cooperative catalysis of Pt/C and acid resin for the production of 2,5-dimethyltetrahydrofuran from biomass derived 2,5-hexanedione under mild conditions
Authors: Zhou Huacong , Song Jinliang , Meng Qinglei , He Zhenhong , Jiang Zhiwei , Zhou Baowen , Liu Huizhen , Han Buxing
Published: September 2015

Biomass derived 2,5-hexanedione can be converted to 2,5-dimethyltetrahydrofuran with 99% yield by using Pt/C and the Amberlite®120H system under mild conditions.
Evaluation of binding competition and group epitopes of acetylcholinesterase inhibitors by STD NMR, Tr-NOESY, DOSY and molecular docking: an old approach but new findings
Authors: Tanoli Nazish U. , Tanoli Sheraz A. K. , Ferreira Antonio G. , Gul Sana , Ul-Haq Zaheer
Published: September 2015

We suggest that the small inhibitors of AChE like coumarin and gallic acid's structure-based scaffolds may help in controlling Alzheimer's disease.
Hydrolysable core crosslinked particles for receptor-mediated pH-sensitive anticancer drug delivery
Authors: Liu Xifeng , Lee Miller II A. , Waletzki Brian E. , Mamo Tewodros K. , Yaszemski Michael J. , Lu Lichun
Published: September 2015

An extracellular stable micelle with a folate conjugated surface, a crosslinked core and pH-sensitive hydrolysable bonds was developed for cancer targeted drug delivery.
A two-step method to synthesize water-dispersible Mn:ZnSe/ZnO core/shell quantum dots with pure dopant emission
Authors: Xu Xiaojing , Qi Zhengqing , Zhao Zengxia , Wang Chunlei , Lu Changgui , Xu Shuhong , Cui Yiping
Published: September 2015

Water-soluble Mn:ZnSe/ZnO core/shell quantum dots with pure dopant emission were prepared via a two-step method.
A novel alkali and cosolvent thickening mechanism for latex
Authors: He Lang , Yu Yue , Cai Zhengwei , Wang Di , Hong Xinlin
Published: September 2015

In this study, alkali-swellable acrylic latex (resin) and coalescent ethylene glycol butyl ether were combined to thicken the coating without the use of any thickeners.
Interaction studies reveal specific recognition of an anti-inflammatory polyphosphorhydrazone dendrimer by human monocytes
Authors: Ledall Jérémy , Fruchon Séverine , Garzoni Matteo , Pavan Giovanni M. , Caminade Anne-Marie , Turrin Cédric-Olivier , Blanzat Muriel , Poupot Rémy
Published: September 2015

Specific interaction and internalization of an azabisphosphonate-capped polyphosphorhydrazone dendrimer lead to anti-inflammatory activation of human monocytes.
Full solution processed mesostructured optical resonators integrating colloidal semiconductor quantum dots
Authors: Calvo Mauricio E. , Hidalgo Nuria , Schierholz Roland , Kovács András , Fernández Asunción , Bellino Martín G. , Soler-Illia Galo J. A. A. , Míguez Hernán
Published: September 2015

Herein we show a solution based synthetic pathway to obtain a resonant optical cavity with embedded colloidal semiconductor quantum dots (CSQDs).
Diastereoselective synthesis of spiro[benzo[d]pyrrolo[2,1-b]thiazole-3,3′-indolines] via cycloaddition reaction of N-phenacylbenzothiazolium bromides and 3-methyleneoxindoles
Authors: Shen Guo-Liang , Sun Jing , Yan Chao-Guo
Published: September 2015

The domino cycloaddition reactions of N-phenacylbenzothiazolium bromides with 3-phenacylideneoxindoles or ethyl 2-(2-oxoindolin-3-ylidene)acetates afforded spiro[benzo[d]pyrrolo[2,1-b]thiazole-3,3′-indolines] in good yields and with high diastereoselectivity.
Magnetic ordering in TCNQ-based metal–organic frameworks with host–guest interactions
Authors: Zhang Xuan , Saber Mohamed R. , Prosvirin Andrey P. , Reibenspies Joseph H. , Sun Lei , Ballesteros-Rivas Maria , Zhao Hanhua , Dunbar Kim R.
Published: September 2015

Host–guest interactions between the TCNQ-based MOF and aromatic molecules have been found to modulate spontaneous magnetization behavior at low temperatures.
Time-dependent antioxidative responses of ramie (Boehmeria nivea (L.) Gaudich) to moderate cadmium stress and its up-regulation mechanism by spermidine antioxidant
Authors: Zhou Lu , Liu Yunguo , Hu Xi , Zeng Guangming , Wang Yaqin , Hu Xinjiang , Zhou Yaoyu , Tan Xiaofei , Jiang Luhua , Zeng Xiaoxia
Published: September 2015

Cadmium (Cd) is present in soil and water at low concentrations that can be harmful to the biota.
Synergistic strategies for the preparation of highly efficient dye-sensitized solar cells on plastic substrates: combination of chemical and physical sintering
Authors: Li Yuelong , Yoo Kicheon , Lee Doh-Kwon , Kim Jin Young , Son Hae Jung , Kim Jong Hak , Lee Chul-Ho , Míguez Hernán , Ko Min Jae
Published: September 2015

Synergistic strategies combining chemical and physical sintering at low temperature were employed for the preparation of highly efficient dye-sensitized solar cells on plastic substrates.
Development and validation of an ultra-performance liquid chromatography method coupled with tandem mass spectrometry for determination of alizapride in human plasma
Authors: Zaazaa H. E. , Elzanfaly E. S. , Soudi A. T. , Salem M. Y.
Published: September 2015

Representative (a) blank plasma samples, (b) spiked plasma sample at LLQQ (1 ng mL−1) with the IS, (c) spiked plasma sample at QCH (800 ng mL−1) with the IS and (d) real plasma sample at 10 minutes spiked with the IS.
Synthesis and characterization of acrylic acid-2-hydroxyethyl methacrylate IPN hydrogels
Authors: Bera Rabin , Dey Ayan , Datta sarma Arpan , Chakrabarty Debabrata
Published: September 2015

Three different methods have been developed to crosslink the poly(acrylic acid-2-hydroxyethyl methacrylate) to form the hydrogels having tunable swelling, rheological and morphological properties with applicability in dye and heavy metal removal.
Acid-based co-catalysis for oxidative dehydrogenation of ethylbenzene to styrene with CO2 over X zeolite modified by alkali metal cation exchange
Authors: Zhao Guoqing , Chen Huanhui , Li Junhui , Wang Qunlong , Wang Yanan , Ma Shuwen , Zhu Zhirong
Published: September 2015

A variety of the modified X zeolites were used to catalyse the oxidative dehydrogenation of ethylbenzene to styrene with CO2 for the first time.
Hydrothermal properties of the COS/D2 water model: a polarizable charge-on-spring water model, at elevated temperatures and pressures
Authors: Steele-MacInnis Matthew , Reimer Joachim , Bachmann Stephan
Published: September 2015

Molecular simulations have been conducted to assess the pVT properties and static permittivity of the charge-on-spring polarizable water model COS/D2 at hydrothermal conditions from 300 to 450 °C and bulk densities of 0.001 to 1.0 g cm−3.
Effects of post-treatment on the structure and properties of PVDF/FEP blend hollow fiber membranes
Authors: Huang Qing-lin , Wu Yan-jie , Xiao Chang-fa , Chen Kai-kai , Song Liang , Liu Zhen
Published: September 2015

Polyvinylidene fluoride (PVDF)/poly(tetrafluoroethylene-co-hexafluoropropylene) (FEP) blend hollow fiber membranes were prepared by the melt-spinning method.
Tailoring the electrical properties of multilayer MoS2 transistors using ultraviolet light irradiation
Authors: Singh Arun Kumar , Andleeb Shaista , Singh Jai , Eom Jonghwa
Published: September 2015

Modulating the electronic properties of MoS2 is essential in order to obtain the best performance of its electronic and optoelectronic devices as well as enabling fabrication of various complex devices.
Resistivity minima in the disordered cluster glass intermetallic compound Dy5Pd2: influence of quantum interference effects
Authors: Paramanik Tapas , Das I.
Published: September 2015

A resistance minimum in the temperature dependence of Dy5Pd2 has been interpreted in terms of contributions from magnetic and phonon scattering, electron–electron interactions and weak localization.
4-Dodecylbenzenesulfonic acid (DBSA) promoted solvent-free diversity-oriented synthesis of primary carbamates, S-thiocarbamates and ureas
Authors: Sardarian Ali Reza , Inaloo Iman Dindarloo
Published: September 2015

A simple and efficient solvent-free preparation of primary carbamates,S-thiocarbamates and ureas from alcohols, phenols, thiols and amines in the presence of 4-dodecylbenzenesulfonic acid, as a cheap and green Brønsted acid, has been described.
Bromo–nitro substitution on a tertiary α carbon—a previously uncharacterized facet of the Kornblum substitution
Authors: Leonard Matthew J. , McKay Peter G. , Lingham Anthony R.
Published: September 2015

Sodium nitrite in dimethylformamide substitutes nitro for bromine alpha to an amide carbonyl in high yield at a tertiary site.
Pd/C-catalyzed facile synthesis of primary aromatic amides by aminocarbonylation of aryl iodides using ammonia surrogates
Authors: Mane Rajendra S. , Bhanage Bhalchandra M.
Published: September 2015

Use of Pd/C as an efficient, phosphine free, heterogeneous and recyclable catalyst for one pot carbonylative synthesis of primary aromatic amides has been demonstrated.
Hierarchical assembly may be a way to make large information-rich structures
Authors: Whitelam Stephen
Published: September 2015

Hierarchical assembly may provide a way of making large structures in which each component is of a distinct type.
Self-healing multilayer polyelectrolyte composite film with chitosan and poly(acrylic acid)
Authors: Zhu Yanxi , Xuan Hongyun , Ren Jiaoyu , Ge Liqin
Published: September 2015

If self-healing materials can be prepared via simple technology and methods using nontoxic materials, this would be a great step forward in the creation of environmentally friendly self-healing materials.
A new approach to synthesize MoO2@C for high-rate lithium ion batteries
Authors: Wang Ying , Huang Zhenguo , Wang Yijing
Published: September 2015

A new approach is used to synthesize MoO2@C with excellent capacity, rate capability and cycle stability for LIBs.
Li-ion conductivity in Li9S3N
Authors: Miara Lincoln J. , Suzuki Naoki , Richards William D. , Wang Yan , Kim Jae Chul , Ceder Gerbrand
Published: September 2015

Li9S3N is a novel Li–metal barrier coating for all-solid-state batteries. The conductivity is greatly improved by substitution.
Catalyst-free dynamic exchange of aromatic Schiff base bonds and its application to self-healing and remolding of crosslinked polymers
Authors: Lei Zhou Qiao , Xie Pu , Rong Min Zhi , Zhang Ming Qiu
Published: September 2015

Crosslinked polyacrylate is self-healed and reprocessed through rearrangement of networks based on catalyst-free dynamic exchange of aromatic Schiff base bonds.
Enantiomers of cysteine-modified SeNPs (d/lSeNPs) as inhibitors of metal-induced Aβ aggregation in Alzheimer's disease
Authors: Zhou Xianbo , Sun Jing , Yin Tiantian , Le Fangling , Yang Licong , Liu Yanan , Liu Jie
Published: September 2015

Chiral molecules, which selectively target and inhibit amyloid β-peptide (Aβ) aggregation, have potential use as therapeutic agents for the treatment of Alzheimer's disease (AD).
Enhanced thermoelectric performance of n-type Cu0.008Bi2Te2.7Se0.3 by band engineering
Authors: Lee Kyu Hyoung , Kim Sang Il , Mun Hyeona , Ryu Byungki , Choi Soon-Mok , Park Hee Jung , Hwang Sungwoo , Kim Sung Wng
Published: September 2015

We herein report the significantly improved thermoelectric performance of n-type Bi2Te2.7Se0.3 polycrystalline bulks through band structure engineering achieved by Au-doping.
Out of sight but not out of mind: the role of counter electrodes in polymer-based solid-state electrochromic devices
Authors: Eric Shen D. , Österholm Anna M. , Reynolds John R.
Published: September 2015

Through the appropriate choice of counter electrode material, effective electrochromic polymer devices with low operating voltages, no break-in time, high optical contrast, and short switching times are produced.
Ce dopant effects on NaYF4 particle morphology and optical properties
Authors: Zhao Xinyu , Tan Mei Chee
Published: September 2015

Significant IR emission enhancement in both NaYF4 microparticles and nanoparticles was obtained using the tri-dopant scheme of Ce, Yb and Er.
Solid solution magnetic FeNi nanostrand–polymer composites by connecting-coarsening assembly
Authors: Barcikowski Stephan , Baranowski Thomas , Durmus Yigit , Wiedwald Ulf , Gökce Bilal
Published: September 2015

Transparent FeNi–PMMA composites with three different filling factors showing nanostrands of different length and thickness.
Statistical properties of three-dimensional two-fluid plasma model
Authors: Qaisrani M. Hasnain , Xia ZhenWei , Zou Dandan
Published: September 2015

The nonlinear dynamics of incompressible non-dissipative two-fluid plasma model is investigated through classical Gibbs ensemble methods. Liouville's theorem of phase space for each wave number is proved, and the absolute equilibrium spectra for Galerkin truncated two-fluid model are calculated. In two-fluid theory, the equilibrium is built on the conservation of three quadratic invariants: the total energy and the self-helicities for ions and electrons fluid, respectively. The implications of statistic equilibrium spectra with arbitrary ratios of conserved invariants are discussed.
Morphological analysis of GeTe in inline phase change switches
Authors: King Matthew R. , El-Hinnawy Nabil , Salmon Mike , Gu Jitty , Wagner Brian P. , Jones Evan B. , Borodulin Pavel , Howell Robert S. , Nichols Doyle T. , Young Robert M.
Published: September 2015

Crystallization and amorphization phenomena in indirectly heated phase change material-based devices were investigated. Scanning transmission electron microscopy was utilized to explore GeTe phase transition processes in the context of the unique inline phase change switch (IPCS) architecture. A monolithically integrated thin film heating element successfully converted GeTe to ON and OFF states. Device cycling prompted the formation of an active area which sustains the majority of structural changes during pulsing. A transition region on both sides of the active area consisting of polycrystalline GeTe and small nuclei (<15 nm) in an amorphous matrix was also observed. The switching mechanism, determined by variations in pulsing parameters, was shown to be predominantly growth-driven. A preliminary model for crystallization and amorphization in IPCS devices is presented.
Photo-Seebeck effect in polycrystalline ZnO
Authors: Horikawa Ayaka , Igarashi Taichi , Terasaki Ichiro , Okazaki Ryuji
Published: September 2015

We have measured the Seebeck coefficient and the resistance under light illumination of 365 nm in a ceramic sample of ZnO at 100, 150, and 200 K, and have analyzed the photo-Seebeck coefficient and the photoconductivity using a two-layer model. We have evaluated the photo-doped carrier concentration from the magnitude of the photo-Seebeck coefficient to be of the order of 1019 cm−3, as is similar to the case of thin-film and single-crystal samples. The photo-doping effects are compared among ceramic, single crystal, and thin-film samples.
Internal stresses in pre-stressed micron-scale aluminum core-shell particles and their improved reactivity
Authors: Levitas Valery I. , McCollum Jena , Pantoya Michelle L. , Tamura Nobumichi
Published: September 2015

Dilatation of aluminum (Al) core for micron-scale particles covered by alumina (Al2O3) shell was measured utilizing x-ray diffraction with synchrotron radiation for untreated particles and particles after annealing at 573 K and fast quenching at 0.46 K/s. Such a treatment led to the increase in flame rate for Al + CuO composite by 32% and is consistent with theoretical predictions based on the melt-dispersion mechanism of reaction for Al particles. Experimental results confirmed theoretical estimates and proved that the improvement of Al reactivity is due to internal stresses. This opens new ways of controlling particle reactivity through creating and monitoring internal stresses.
High resolution infrared and Raman spectra of 13C12CD2: The CD stretching fundamentals and associated combination and hot bands
Authors: Di Lonardo G. , Fusina L. , Canè E. , Tamassia F. , Martínez R. Z. , Bermejo D.
Published: September 2015

Infrared and Raman spectra of mono 13C fully deuterated acetylene, 13C12CD2, have been recorded and analysed to obtain detailed information on the C—D stretching fundamentals and associated combination, overtone, and hot bands. Infrared spectra were recorded at an instrumental resolution ranging between 0.006 and 0.01 cm−1 in the region 1800–7800 cm−1. Sixty new bands involving the ν1 and ν3 C—D stretching modes also associated with the ν4 and ν5 bending vibrations have been observed and analysed. In total, 5881 transitions have been assigned in the investigated spectral region. In addition, the Q branch of the ν1 fundamental was recorded using inverse Raman spectroscopy, with an instrumental resolution of about 0.003 cm−1. The transitions relative to each stretching mode, i.e., the fundamental band, its first overtone, and associated hot and combination bands involving bending states with υ4 + υ5 up to 2 were fitted simultaneously. The usual Hamiltonian appropriate to a linear molecule, including vibration and rotation l-type and the Darling–Dennison interaction between υ4 = 2 and υ5 = 2 levels associated with the stretching states, was adopted for the analysis. The standard deviation for each global fit is ≤0.0004 cm−1, of the same order of magnitude of the measurement precision. Slightly improved parameters for the bending and the ν2 manifold have been also determined. Precise values of spectroscopic parameters deperturbed from the resonance interactions have been obtained. They provide quantitative information on the anharmonic character of the potential energy surface, which can be useful, in addition to those reported in the literature, for the determination of a general anharmonic force field for the molecule. Finally, the obtained values of the Darling–Dennison constants can be valuable for understanding energy flows between independent vibrations.
Dynamics of social contagions with limited contact capacity
Authors: Wang Wei , Shu Panpan , Zhu Yu-Xiao , Tang Ming , Zhang Yi-Cheng
Published: September 2015

Individuals are always limited by some inelastic resources, such as time and energy, which restrict them to dedicate to social interaction and limit their contact capacities. Contact capacity plays an important role in dynamics of social contagions, which so far has eluded theoretical analysis. In this paper, we first propose a non-Markovian model to understand the effects of contact capacity on social contagions, in which each adopted individual can only contact and transmit the information to a finite number of neighbors. We then develop a heterogeneous edge-based compartmental theory for this model, and a remarkable agreement with simulations is obtained. Through theory and simulations, we find that enlarging the contact capacity makes the network more fragile to behavior spreading. Interestingly, we find that both the continuous and discontinuous dependence of the final adoption size on the information transmission probability can arise. There is a crossover phenomenon between the two types of dependence. More specifically, the crossover phenomenon can be induced by enlarging the contact capacity only when the degree exponent is above a critical degree exponent, while the final behavior adoption size always grows continuously for any contact capacity when degree exponent is below the critical degree exponent.
Effects of electron beam parameters and velocity spread on radio frequency output of a photonic band gap cavity gyrotron oscillator
Authors: Singh Ashutosh , Jain P. K.
Published: September 2015

In this paper, the effects of electron beam parameters and velocity spread on the RF behavior of a metallic photonic band gap (PBG) cavity gyrotron operating at 35 GHz with TE041–like mode have been theoretically demonstrated. PBG cavity is used here to achieve a single mode operation of the overmoded cavity. The nonlinear time-dependent multimode analysis has been used to observe the beam-wave interaction behavior of the PBG cavity gyrotron, and a commercially available PIC code “CST Particle Studio” has been reconfigured to obtain 3D simulation results in order to validate the analytical values. The output power for this typical PBG gyrotron has been obtained ∼108 kW with ∼15.5% efficiency in a well confined TE041–like mode, while all other competing modes have significantly low values of power output. The output power and efficiency of a gyrotron depend highly on the electron beam parameters and velocity spread. The influence of several electron beam parameters, e.g., beam voltage, beam current, beam velocity pitch factor, and DC magnetic field, on the PBG gyrotron operations has been investigated. This study would be helpful in optimising the electron beam parameters and estimating accurate RF output power of the high frequency PBG cavity based gyrotron oscillators.
Method to integrate full particle orbit in toroidal plasmas
Authors: Wei X. S. , Xiao Y. , Kuley A. , Lin Z.
Published: September 2015

It is important to integrate full particle orbit accurately when studying charged particle dynamics in electromagnetic waves with frequency higher than cyclotron frequency. We have derived a form of the Boris scheme using magnetic coordinates, which can be used effectively to integrate the cyclotron orbit in toroidal geometry over a long period of time. The new method has been verified by a full particle orbit simulation in toroidal geometry without high frequency waves. The full particle orbit calculation recovers guiding center banana orbit. This method has better numeric properties than the conventional Runge-Kutta method for conserving particle energy and magnetic moment. The toroidal precession frequency is found to match that from guiding center simulation. Many other important phenomena in the presence of an electric field, such as E×B drift, Ware pinch effect and neoclassical polarization drift are also verified by the full orbit simulation.