bluuebunny/crossref_metadata_2025 huggingface dataset:
The HRM Model Based on Competency Model in the Context of New Age Intelligence
Authors: Zhang Zhihua
Published: May 2023

In the new era of rapid technological development, new technologies are emerging: mobile positioning technology, face recognition technology, two-dimensional code technology, artificial intelligence technology, etc. In the trend of the times, these emerging technologies continue to penetrate into people’s daily life and influence their social habits. At present, the shadow of emerging technologies such as artificial intelligence has already appeared in human resource management and organizational behavior, and the application of these emerging technologies will certainly promote the change of human resource management and organizational behavior and have a double impact on human resource management and organizational behavior. On the one hand, emerging technologies such as artificial intelligence bring new opportunities for the development of human resources, which can not only improve the efficiency of human resource management, optimize human resource organizational behavior, and accelerate the transformation of enterprise management mode. On the other hand, the application of these emerging technologies also brings new challenges for HR development and management: the enterprises’ demand for low-end positions decreases, increasing the employment pressure in the talent market; the enterprises’ development faces transformation and rectification, increasing the difficulty of survival of small enterprises; the employment difficulties and development prospects of HR departments are uncertain. In the context of the new era of intelligence, the impact of emerging technologies on human resource management and organizational behavior is bound to intensify, and enterprises should innovate ideas and integrate new ways and methods to upgrade the traditional human resource management model and seize the opportunity to promote human resource management changes, so that emerging technologies such as artificial intelligence can inject new vitality into modern human resource management. Based on this, this paper proposes an enterprise HR management strategy based on the competency model and combines it with a practical case study and finds that the strategy has been recognized by 91% of employees within the company and has effectively improved the efficiency of HR management.
Assessing Peracetic Acid Application Methodology and Impacts on Fluidized Sand Biofilter Performance
Authors: Lepine Christine , Redman Natalie , Murray Megan , Lazado Carlo C. , Johansen Lill-Heidi , Espmark Åsa Maria , Davidson John , Good Christopher
Published: May 2023

Nitrifying biofilters oxidize harmful ammonia excreted by fish into less toxic nitrate within recirculating aquaculture systems (RAS). Biofilter performance and resulting RAS water quality largely depend on a robust microbiome that effectively converts nitrogenous wastes; however, occasional use of water disinfectants may also be necessary to reduce or eliminate specific fish pathogens. Disinfectants and sanitizers such as peracetic acid (PAA) work by disrupting microbial activity and could unintentionally alter the microbially-driven nitrification biofiltration process if allowed to circulate within an RAS. Furthermore, the target concentration and application method of PAA may influence the level of biofilter disruption. For this study, 12 replicated experimental-scale fluidized sand biofilters were dosed with PAA to achieve target concentrations ranging from 1.0-–2.5 mg/L, a typical low-dose treatment range to reduce or eliminate opportunistic pathogens. Two application methods were compared, including (i) a single pulse of PAA added every other day for five days, and (ii) smaller doses of PAA added every five minutes over four hours. The PAA decay was monitored and predosing and postdosing water quality parameters were assessed. Regardless of the target concentration or application method, PAA addition within the tested range did not cause significant disruption to the biofilters’ nitrification processes. This research demonstrates that PAA may be a viable water sanitizer for the RAS industry, although further research to refine safe application protocols is necessary.
Time-Frequency Volatility Spillovers among Major International Financial Markets: Perspective from Global Extreme Events
Authors: Xiao Yao , Dong Zibing , Huang Shihua , Li Yanshuang , Wang Jian , Zhuang Xintian
Published: May 2023

In the context of the gradual intensification of the Russia-Ukraine conflict and the continuous spread of the COVID-19 pandemic, this paper concentrates on the impact of global extreme events such as the COVID-19 pandemic and the Russia-Ukraine conflict on the risk spillovers among major international financial markets. First, to measure the impact of the extreme events the on the volatility spillovers among major international financial markets in the time-frequency domain, we combine the TVP-VAR-based connectedness method and BK frequency connectedness approach and focus on the total, directional, and net volatility spillovers. Second, the network visualization method is applied to outline the structural change in the risk contagion, paths, and roles among international financial markets during different periods of global extreme events. The empirical results indicate that the risk spillovers (total, directional, and net spillovers) among international financial markets and the roles played by each market in the process of risk contagion have changed significantly in different periods of global extreme events. Furthermore, volatility spillovers among international financial markets are driven mainly by the high-frequency component (short-term spillovers) during the full sample time. However, the effects of the extreme events also persist in the medium and long terms. Our findings may help understand the dynamics among international financial markets under extreme shocks and provide significant implications for portfolio managers, investors, and government agencies in times of extreme events.
Cartilage Damage Pathological Characteristics of Diabetic Neuropathic Osteoarthropathy
Authors: Liu Pei-Long , Diao Jia-Yu , Wang Qiong , Liu Huan , Zhang Yan , Liang Jing-Qi , Zhang Feng , Liang Xiao-Jun , Zhao Hong-Mou
Published: May 2023

Background. Diabetic neuropathic osteoarthropathy (DNOAP) is a rare and easily missed complication for diabetes that leads to increased morbidity and mortality. DNOAP is characterized by progressive destruction of bone and joint, but its pathogenesis remains elusive. We herein aimed to investigate the pathological features and pathogenesis of the cartilages damage in DNOAP patients. Methods. The articular cartilages of eight patients with DNOAP and eight normal controls were included. Masson staining and safranine O/fixed green staining (S‐O) were used to observe the histopathological characteristics of cartilage. The ultrastructure and morphology of chondrocytes were detected by electron microscopy and toluidine blue staining. Chondrocytes were isolated from DNOAP group and control group. The expression of receptor activator of nuclear factor kappaB ligand (RANKL), osteoprotegerin (OPG), interleukin‐1 beta (IL‐1β), interleukin‐6 (IL‐6), tumor necrosis factor‐alpha (TNF‐α), and Aggrecan protein was evaluated by western blot. Reactive oxygen species (ROS) levels were measured using a 2′,7′‐dichlorofluorescin diacetate (DCFH‐DA) probe. The percentage of apoptotic cells was determined by flow cytometry (FCM). The chondrocytes were cultured with different glucose concentrations to observe the expression of RANKL and OPG. Results. Compared with the control group, the DNOAP group showed fewer chondrocytes, subchondral bone hyperplasia, and structural disorder, and a large number of osteoclasts formed in the subchondral bone area. Moreover, mitochondrial and endoplasmic reticulum swellings were observed in the DNOAP chondrocytes. The chromatin was partially broken and concentrated at the edge of nuclear membrane. The ROS fluorescence intensity of chondrocyte in DNOAP group was higher than that in normal control group (28.1 ± 2.3 vs. 11.9 ± 0.7; P < 0.05). The expression of RANKL, TNF‐α, IL‐1β, and IL‐6 protein in DNOAP group was higher than that in normal control group, whereas OPG and Aggrecan protein were lower than that in normal control group (both P < 0.05). FCM showed that the apoptotic rate of chondrocyte in DNOAP group was higher than that in normal control group (P < 0.05). The RANKL/OPG ratio showed significant upward trend when the concentration of glucose was over than 15 mM. Conclusions. DNOAP patients tend to have severe destruction of articular cartilage and collapse of organelle structure including mitochondrion and endoplasm reticulum. Indicators of bone metabolism (RANKL and OPG) and inflammatory cytokines (IL‐1β, IL‐6, and TNF‐α) play an important role in promoting the pathogenesis of DNOAP. The glucose concentration higher than 15 mM made the RANKL/OPG ratio change rapidly.
Multiband Pattern Synthesis of Time-Modulated Conformal Array with Quadratic Convex Optimization Algorithm
Authors: Dong Xiao , Li Hailin , Wang Ke , Zhang Yanwei , Chu Yongyan
Published: May 2023

Aiming at the multiband pattern synthesis problem of time-modulated conformal array antenna, a quadratic convex optimization algorithm is proposed for sum and difference beamforming with low sidelobe levels. This articles method synthesizes a difference beam with a low sidelobe level by generating nulls at the center frequency band and optimizing the switch-on duration time of array elements. And the sum beamforming and sidelobe suppression of the first-order sideband are realized by optimizing the switch-on instant time of the array elements. The proposed algorithm has excellent properties of sidelobe suppression and angular sweep. The simulation results of circular and satellite array antenna verify the effectiveness of the algorithm.
Upadacitinib Is a Better Choice than Abrocitinib for Patients with Moderate-to-Severe Atopic Dermatitis: An Updated Meta-Analysis
Authors: Zhang Ying , Hong Pan , Rai Saroj , Liu Ruikang , Liu Bo
Published: May 2023

Background. Blocking agent for immune cytokine pathways is a novel treatment for atopic dermatitis (AD). Janus kinase (JAK) family is one of the cytoplasmic tyrosine kinases that mediate a variety of cytokines. Eight randomized controlled trials (RCTs) of JAK1 inhibitors (upadacitinib and abrocitinib) in AD have been published in the past three years. Objective. To evaluate the efficacy and safety of JAK1 inhibitors and compare upadacitinib with abrocitinib for the treatment of moderate-to-severe AD. Methods. Two independent reviewers searched Medline, Embase, Web of Science, and Cochrane databases updated on Apr 11th, 2023. We included data from phase two and three RCTs. Primary outcomes included the proportion of Investigator’s Global Assessment (IGA) responders and Eczema Area and Severity Index-75 (EASI-75) responders. Results. In all, eight RCTs were included in our study with 4634 moderate-to-severe AD patients. Both JAK1 inhibitors showed apparent therapeutic effects, but the 200 mg abrocitinib group demonstrated less efficacy than the 30 mg upadacitinib group in IGA responders (end of treatment) and EASI-75 responders (after 2 weeks of treatment). However, both JAK1 inhibitor groups demonstrated significantly higher risks of acne (9.0%) and headache (6.3%). Besides, upadacitinib showed significantly higher risks of upper respiratory tract infection (7.6%) and nasopharyngitis (9.7%), and abrocitinib showed significantly higher risks of nausea (9.6%). Conclusion. JAK1 inhibitors demonstrate promising efficacy in AD with rapid response and dose-dependent response and significantly higher risks of acne and headache. Based on existing data, oral 30 mg upadacitinib QD has better outcome than oral 200 mg abrocitinib QD and is a recommended dosage regimen for moderate-to-severe AD patients. Oral 15 mg upadacitinib QD might be an alternative dosage regimen in case of treatment-emergent adverse events.
Lymphocyte-to-C-Reactive Protein Ratio as an Early Sepsis Biomarker for Neonates with Suspected Sepsis
Authors: Li Xiaojuan , Wei Yulei , Xu Zhe , Li Tiewei , Dong Geng , Liu Xinrui , Zhu Zhiwei , Yang Jianwei , Yang Junmei
Published: May 2023

Background. Neonatal sepsis is an extremely dangerous and fatal disease among neonates, and its timely diagnosis is critical to treatment. This research is aimed at evaluating the clinical significance of the lymphocyte-to-C-reactive protein ratio (LCR) as an early sepsis indicator in neonates with suspected sepsis. Methods. Between January 2016 and December 2021, 1269 neonates suspected of developing sepsis were included in this research. Among them, sepsis was diagnosed in 819 neonates, with 448 severe cases, as per the International Pediatric Sepsis Consensus. Data related to clinical and laboratory tests were obtained via electronic medical records. LCR was calculated as total lymphocyte (109 cells/L)/C-reactive protein (mg/L). Multivariate logistic regression analysis was employed to evaluate the effectiveness of LCR as an independent indicator for determining sepsis in susceptible sepsis neonates. Receiver operating characteristic (ROC) curve analysis was conducted for investigating the diagnostic significance of LCR in sepsis. When suitable, the statistical tool SPSS 24.0 was used for statistical analyses. Results. LCR decreased significantly in the control, mild, and severe sepsis groups. Further analyses exhibited that there was a substantially greater incidence of sepsis in neonates in the low-LCR group (

LCR
≤
3.94

) as opposed to the higher LCR group (

LCR
>
3.94

) (77.6% vs. 51.4%,

p
<
0.001

). Correlation analysis indicated a substantial negative association of LCR with procalcitonin (

r
=
−
0.519

,

p
<
0.001

) and hospital stay duration (

r
=
−
0.258

,

p
<
0.001

). Multiple logistic regression analysis depicted LCR as an independent indicator for identifying sepsis and severe cases of this disease. ROC curve analysis indicated the optimal cutoff value of LCR in identifying sepsis to be 2.10, with 88% sensitivity and 55% specificity. Conclusions. LCR has proven to be a potentially strong biomarker capable of identifying sepsis in a timely manner in neonates suspected to have the disease.
An Overview on Multi-Level Inverter Topologies for Grid-Tied PV System
Authors: Anjaneya Vara Prasad Paneti , Dhanamjayulu C.
Published: May 2023

Over the years, multi-level inverter (MLI) usage has increased widely for several applications like motor drives, renewable energy source- (RES-) fed grids, and electric vehicles (EVs). In recent scenarios, the development of RES, grids, and EVs is in advanced mode, and this became the reason for innovations in recent MLI topologies. The new topologies have more advantages, unique features, and abilities to meet the advanced requirements. Therefore, these new topologies are preferable for recent applications. In this paper, a detailed review of recent MLI topologies, controllers, and PWM techniques is done by considering some physical aspects as well as some performance aspects. Also, the particular focus is on the MLI topologies, controllers, and PWM techniques for photovoltaic (PV) system-fed grids and microgrids to provide details for selecting the suitable MLI topology and PWM technique for PV systems. The detailed analysis of each topology is discussed for categorizing specific applications along with futuristic expansion aspects. The future research scope on MLI topologies for PV systems is summarized with appropriate comprehensive comparisons along with their unique features over other topologies. Also, the advanced controllers and PWM techniques are also discussed with advantages and their wide range of controlling abilities.
Data from Opportunities for Achieving the Cancer Moonshot Goal of a 50% Reduction in Cancer Mortality by 2047
Authors: Shiels Meredith S. , Lipkowitz Stanley , Campos Nicole G. , Schiffman Mark , Schiller John T. , Freedman Neal D. , Berrington de González Amy
Published: May 2023

Abstract
On February 2, 2022, President Biden and First Lady Dr. Biden reignited the Cancer Moonshot, setting a new goal to reduce age-standardized cancer mortality rates by at least 50% over the next 25 years in the United States. We estimated trends in U.S. cancer mortality during 2000 to 2019 for all cancers and the six leading types (lung, colorectum, pancreas, breast, prostate, liver). Cancer death rates overall declined by 1.4% per year from 2000 to 2015, accelerating to 2.3% per year during 2016 to 2019, driven by strong declines in lung cancer mortality (−4.7%/year, 2014 to 2019). Recent declines in colorectal (−2.0%/year, 2010–2019) and breast cancer death rates (−1.2%/year, 2013–2019) also contributed. However, trends for other cancer types were less promising. To achieve the Moonshot goal, progress against lung, colorectal, and breast cancer deaths needs to be maintained and/or accelerated, and new strategies for prostate, liver, pancreatic, and other cancers are needed. We reviewed opportunities to prevent, detect, and treat these common cancers that could further reduce population-level cancer death rates and also reduce disparities.
Significance:
We reviewed opportunities to prevent, detect, and treat common cancers, and show that to achieve the Moonshot goal, progress against lung, colorectal, and breast cancer deaths needs to be maintained and/or accelerated, and new strategies for prostate, liver, pancreatic, and other cancers are needed.

See related commentary by Bertagnolli et al., p. 1049.

This article is highlighted in the In This Issue feature, p. 1027
Supplementary Table S2 from Prediagnostic CT or MRI Utilization and Outcomes in Hepatocellular Carcinoma: SEER-Medicare Database Analysis
Authors: Karim Mohammad A , Singal Amit G , Kum Hye Chung , Lee Yi-Te , Park Sulki , Rich Nicole E , Noureddin Mazen , Yang Ju Dong
Published: May 2023

Supplementary Table S2 shows the demographic and clinical factors associated with overall survival for HCC patients after adjusting for lead-time bias.
Supplementary Table S1 from Prediagnostic CT or MRI Utilization and Outcomes in Hepatocellular Carcinoma: SEER-Medicare Database Analysis
Authors: Karim Mohammad A , Singal Amit G , Kum Hye Chung , Lee Yi-Te , Park Sulki , Rich Nicole E , Noureddin Mazen , Yang Ju Dong
Published: May 2023

Supplementary Table S1 shows the demographic and clinical factors associated with receipt of MRI/CT test in HCC patients.
Supplementary File 9 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Differentially abundant microbial enzyme classes (EC) and metabolic pathways (MaAsLin2).
Supplementary File 8 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Differentially abundant microbial taxa (MaAsLin2)
Supplementary File 7 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Microbial enzyme classes (EC) and metabolic pathway profiles.
Supplementary File 6 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Microbial relative transcriptional abundances in the samples.
Supplementary File 5 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Host differentially expressed genes and pathways by lymph node status
Supplementary File 3 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Host differenntially expressed genes
Supplementary File 2 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Detailed sequencing and mapping statistics.
Supplementary File 12 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Host pathways (GSEA genesets) correlating with microbial enzyme classes
FIGURE 5 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

HL expression by Cutibacterium acnes. Relative abundance of HL transcripts in individual samples. The transcripts were exclusively contributed by Cutibacterium acnes based on HUMAnN 3.0 results.
FIGURE 2 from Integrative Metatranscriptomic Analysis Reveals Disease-specific Microbiome–host Interactions in Oral Squamous Cell Carcinoma
Authors: Jain Vinay , Baraniya Divyashri , El-Hadedy Doaa E. , Chen Tsute , Slifker Michael , Alakwaa Fadhl , Cai Kathy Q. , Chitrala Kumaraswamy N. , Fundakowski Christopher , Al-Hebshi Nezar N.
Published: May 2023

Host transcriptome. Sequences were mapped to human reference GRCh38 and quantified at the gene level using STAR aligner and HTSeq, respectively. DESeq2 was used to identify DEGs which are depicted in volcano plots for tumor versus adjacent normal (paired comparison; A), tumor versus HC (B), and adjacent normal versus HC (C)—the color code in the volcano plots corresponds to the fold change and FDR cutoffs (2 and 0.05, respectively). D, A PCA plot based on the most variable 1,500 DEGs, generated using “plotPCA" function from DESeq2 R/Bioconductor package. Lists of DEGs preranked by Wald statistic were used as input for GSEA to identify upregulated and downregulated pathways in each contrast (E–G) based on Hallmark gene sets (MSigDB 7.1).
The cinema of Rithy Panh: everything has a soul
Authors: Philip Andrew I.
Published: May 2023

Over four decades of making films, director Rithy Panh continues to expand the possibilities of documentary filmmaking. His traumatic experiences of the Khmer Rouge’s dehumanising regime drive the creative impulse that makes him Cambodia’s most famous director. This interdisciplinary collection elaborates upon the global geopolitical concerns such as migration, exile, imperialism, and gender that Panh astutely implicates within the specificities of Cambodian history. Not only does Panh expose the role cinema plays in reifying structures of oppression, he also shows how it might also produce a measure of redemption.
Downregulation of FKBP5 Promotes Atrial Arrhythmogenesis
Authors: Wang Xiaolei , Song Jia , Yuan Yue , Li Luge , Abu-Taha Issam , Heijman Jordi , Sun Liang , Dobrev Shokoufeh , Kamler Markus , Xie Liang , Wehrens Xander H.T. , Horrigan Frank T. , Dobrev Dobromir , Li Na
Published: May 2023

Background:

Atrial fibrillation (AF), the most common arrhythmia, is associated with the downregulation of
FKBP5
(encoding FKBP5 [FK506 binding protein 5]). However, the function of FKBP5 in the heart remains unknown. Here, we elucidate the consequences of cardiomyocyte-restricted loss of FKBP5 on cardiac function and AF development and study the underlying mechanisms.

Methods:

Right atrial samples from patients with AF were used to assess the protein levels of FKBP5. A cardiomyocyte-specific FKBP5 knockdown mouse model was established by crossbreeding
Fkbp5

flox/flox

mice with
Myh6

MerCreMer/+

mice. Cardiac function and AF inducibility were assessed by echocardiography and programmed intracardiac stimulation. Histology, optical mapping, cellular electrophysiology, and biochemistry were employed to elucidate the proarrhythmic mechanisms due to loss of cardiomyocyte FKBP5.

Results:

FKBP5 protein levels were lower in the atrial lysates of patients with paroxysmal AF or long-lasting persistent (chronic) AF. Cardiomyocyte-specific knockdown mice exhibited increased AF inducibility and duration compared with control mice. Enhanced AF susceptibility in cardiomyocyte-specific knockdown mice was associated with the development of action potential alternans and spontaneous Ca
2+
waves, and increased protein levels and activity of the NCX1 (Na
+
/Ca
2+
-exchanger 1), mimicking the cellular phenotype of chronic AF patients. FKBP5-deficiency enhanced transcription of
Slc8a1
(encoding NCX1) via transcription factor hypoxia-inducible factor 1α. In vitro studies revealed that FKBP5 negatively modulated the protein levels of hypoxia-inducible factor 1α by competitively interacting with heat-shock protein 90. Injections of the heat-shock protein 90 inhibitor 17-AAG normalized protein levels of hypoxia-inducible factor 1α and NCX1 and reduced AF susceptibility in cardiomyocyte-specific knockdown mice. Furthermore, the atrial cardiomyocyte-selective knockdown of FKBP5 was sufficient to enhance AF arrhythmogenesis.

Conclusions:

This is the first study to demonstrate a role for the FKBP5-deficiency in atrial arrhythmogenesis and to establish FKBP5 as a negative regulator of hypoxia-inducible factor 1α in cardiomyocytes. Our results identify a potential molecular mechanism for the proarrhythmic NCX1 upregulation in chronic AF patients.
Tracking Brand-Associated Polarity-Bearing Topics in User Reviews
Authors: Zhao Runcong , Gui Lin , Yan Hanqi , He Yulan
Published: May 2023

Monitoring online customer reviews is important for business organizations to measure customer satisfaction and better manage their reputations. In this paper, we propose a novel dynamic Brand-Topic Model (dBTM) which is able to automatically detect and track brand-associated sentiment scores and polarity-bearing topics from product reviews organized in temporally ordered time intervals. dBTM models the evolution of the latent brand polarity scores and the topic-word distributions over time by Gaussian state space models. It also incorporates a meta learning strategy to control the update of the topic-word distribution in each time interval in order to ensure smooth topic transitions and better brand score predictions. It has been evaluated on a dataset constructed from MakeupAlley reviews and a hotel review dataset. Experimental results show that dBTM outperforms a number of competitive baselines in brand ranking, achieving a good balance of topic coherence and uniqueness, and extracting well-separated polarity-bearing topics across time intervals.1
Analysis of News Articles on Urban Agriculture using Text Mining from 2012 to 2021
Authors: Park Yumin , Shin Yong-Wook
Published: May 2023

Background and objective: Urbanization and reckless development have caused numerous problems, and urban agriculture with various functions is getting attention as a countermeasure. The purpose of this study is to provide basic data for revitalizing related research and setting effective policy directions by analyzing online articles on urban agriculture from 2012 to 2021.Methods: A total of 15,336 online news articles on urban agriculture were collected from January 1, 2012 to December 31, 2021. For more detailed analysis, the time period was divided by 5 years. Next, nouns were tokenized through morphological analysis, and the main keywords were confirmed by simple frequency analysis and TF-IDF weighting analysis. Following that, LDA topic modeling was conducted to generate topics and words for each period. Python 3.9.5 was applied to run the above analysis.Results: As a result of the analysis, there were four topics in the 1st period and six topics in the 2nd period. Summarizing the topics over time, it was found that urban agriculture is expanding not only to social and cultural areas but also to diverse areas such as welfare and the environment. In addition, as the role of urban agriculture and the demand for services expanded, various education courses and programs were activated, including the implementation of a national professional qualification system, expert training courses, and cultivation technology programs.Conclusion: Based on the findings, urban agriculture is expected to be able to expand into various areas that take multidisciplinary values into account and create various convergence services that follow the trend of the times.
The Effects of Gardening on University Campus on Problem Behaviors of Children with Developmental Disabilities
Authors: Nam Yujung , Yun Sukyoung
Published: May 2023

Background and objective: This study was conducted to investigate the effect that a gardening program based on a garden created on a university campus has on problem behaviors of children with developmental disabilities.Methods: The participants were 13 children with developmental disabilities (10 male and 3 female) with an average age of 10.5 years. The study was conducted from August 21 to November 27, 2021 by implementing a gardening program with total 30 sessions held twice a week. The research sites were three types of spaces created for children with developmental disabilities on D University campus: the healing garden, forest trail, and cherry road. Discrete Trial Training (DTT) was applied to the activities when implementing the gardening program, which was used as an intervention to reduce problem behaviors. The assessment tool was the Child Behavior Checklist for Ages 6-18 (CBCL6-18) with which the parents and the primary caregivers assessed changes in problem behaviors.Results: Externalizing behaviors including aggressive behavior and rule-breaking behavior scored 9.9 before the program, 7.6 during the program, and 7.0 after the program (p < .01), and problem behaviors scored 39.3 before the program, 32.9 during the program, and 31.8 after the program (p < .05), showing a significant change.Conclusion: The gardening program on campus could reduce problem behaviors of children with developmental disabilities. Various activities in the garden are considered to have utility value as a social welfare service and education program.
Ecological Characteristics of Evergreen Forest in Yesong-ri, Wando-gun (Natural Monument No. 40)
Authors: Lee Soo-Dong , Cho Bong-Gyo , Park Gyoung-Sik , Bae Soon-Hyoung
Published: May 2023

Background and objective: Evergreen broad-leaved forests native to the islands of the southwest coast have been adapted to a range of climatic or geographical environmental factors. Although they are of high importance as cultural and ecological landscape resources, they have been damaged by tourism and climate change, and thus measures to protect and manage them are required. This study was conducted to suggest the characteristics of the vegetation structure and management plan of the evergreen forest in Yesong-ri, Natural Monument No. 40.Methods: Twenty-three quadrats were established in the vegetation communities where broad-leaved evergreens dominate or appear in the canopy, understory, and shrub layers, and the area where the vegetation was restored after the buildings was demolished. Based on survey data on the vegetation, the characteristics were identified after classifying the communities using TWINSPAN and DCA ordination techniques.Results: The plant communities were classified into a total of 5 dominant groups: Castanopsis sieboldii-Camellia japonica, C. sieboldii, Celtis sinensis, Neolitsea sericea, Camellia japonica, and Machilus thunbergii-Quercus glauca. The study site was a windbreak forest that has been protected and managed by the villagers for a long time. As time passes, broad-leaved evergreens including N. sericea, Q. acuta, and C. sieboldii have flowed into and spread to the surrounding area. It seems that a similar but unique ecosystem was formed. Looking into the relationship between environmental factors and vegetation distribution, it was analyzed that the slope, clay, and Na+ had direct or indirect effects on the vegetation distribution.Conclusion: The width of the windbreak forest was narrow, and the continuity was interrupted by the indiscriminate activities of tourists, installation of facilities, expansion and construction of warehouses and commercial facilities, and the destruction of peripheral and understory vegetation was in progress. To maintain the integrity of the forest, it is necessary to purchase and demolish buildings and facilities belonging to the interior after establishing boundaries and spheres of influence, and to restore it to a good evergreen broad-leaved forest using a reference model for areas with damaged vegetation and manage it.
Effects of Agro-healing Program on Hand Function, Grip Strength, and Activities of Daily Living Skills of People with Developmental Disabilities
Authors: Yoo Eunha , Ahn Sohyon , Jeong Sunjin , Kang Yongku , Moon Jiwon
Published: May 2023

Background and objective: Agro-healing (care farming) has developed into a new professional area belonging to the field of social horticulture. Agro-healing programs are horticultural activities that serve as social rehabilitation training for the therapeutic treatment of physical and mental disorders, and have caught the attention of scholars in the area of medicine and psychology. Developmental disabilities reduce cognitive function; people with developmental disabilities (PDD) have difficulties in establishing social relationships due to their low visual, hearing, and emotional functions. This study aimed to apply a agro-healing program to PDD and suggest clinical rehabilitation therapy methods for them.Methods: This study selected 32 people who understood its purpose and agreed to participate in the program from April to July 2022 at P Lifelong Education Academy in Wanju-gun and H Developmental Rehabilitation Center in Jeonju-si. There were 15 subjects in the experimental group and 17 in the control group. Pre-test and post-test were conducted to assess hand function, grip strength, and activities of daily living. The results were statistically analyzed using SPSS version 18.0.Results: In the area of upper extremity function, the agro-healing program significantly improved the ability of both hands (right and left) in the experimental group. Within this group, both hands were showed significantly improvement in the the hand function skills of picking up small common objects. Improvement in activities of daily living skills were also statistically significant in the experimental group.Conclusion: In this study, it was confirmed that when a agro-healing program was applied to PDD, it had positive effects on their hand function, grip strength, and activities of daily living skills. It is expected that this can be fully utilized in clinical approaches to rehabilitation therapy for PDD.
The influence of Self-Guided and Guided Forest Therapy Program on Students’ Psychological Benefits
Authors: Shin Won-Sop , Kim Jin-Gun
Published: May 2023

Background and objective: University students' mental health is threatened by various stressors. Forest therapy is considered an effective way to improve mental health. Many researchers have investigated the effectiveness of forest therapy programs operated by guides. Recently, although the concept of a self-guided forest therapy program has emerged without a guide, research is insufficient. Therefore, the present study aimed to explore the influence of self-guided and guided forest therapy program on students' psychological benefits.Methods: We employed a randomized 3 × 3 crossover study. Twenty-three university students were randomly assigned into three groups to eliminate the order effect. Twenty-three university students were randomly exposed to three conditions: a self-guided forest therapy program, a guided forest-therapy program, and routine activities. All participants participated in all interventions once a week for three weeks, and each intervention was conducted over a one-week washout period to eliminate the carryover effect of the intervention. Measures included the Positive and Negative Affect Schedule (PANAS), the Rosenberg Self-esteem Scale (RSES), and the Connectedness to Nature Scale (CNS).Results: As a result, self-guided and guided forest-therapy programs significantly improved participants' negative emotions and natural connectedness compared to routine activities. As for self-esteem, only a guided forest therapy program was higher than daily routine activities.Conclusion: This study shows that not only guided forest therapy programs but also self-guided forest therapy programs have a positive effect on psychological health. Therefore, these findings suggest that running guided forest therapy programs and self-guided forest therapy programs as university in-campus programs will significantly help university students' mental health.
Prelude to a study of the feather mites of Australia (Acariformes: Astigmata)
Authors: HALLIDAY R.B.
Published: May 2023

This paper reviews the state of knowledge of the feather mites of Australia (Arachnida: Acariformes: Astigmata). The known fauna includes 149 species arranged in 95 genera and 24 families, in the Superfamilies Analgoidea and Pterolichoidea. A checklist of the fauna is provided, including bibliographic details for every species and genus. The bird host and collecting localities are listed for every species, and taxonomic and nomenclatural problems are discussed where necessary. The total fauna may include as many as 800 undescribed species. The checklist is preceded by a brief review of some aspects of the biology of feather mites, which have not been studied in the context of the Australian fauna.The correct spelling for a family of respiratory tract parasites is confirmed as Kytoditidae. Dabertia indistincta (Dabert & Atyeo, 1993) comb. n. (Syringobiidae) and Hemialges australis (Trouessart, 1885) comb. n. (Analgidae) are new combinations proposed herein.
Difference in Postoperative Outcomes and Perioperative Resource Utilization Between General Surgeons and Pediatric Surgeons: A Systematic Review
Authors: Eakes Ali M. , Burkbauer Laura , Purcell Laura N. , Akinkuotu Adesola C. , McLean Sean E. , Charles Anthony G. , Phillips Michael R.
Published: May 2023

Background: Both general surgeons (GS) and pediatric surgeons (PS) perform a high volume of appendectomies in pediatric patients, but there is a paucity of data on these outcomes based on surgeon training. We performed a systematic review and meta-analysis to compare postoperative outcomes and perioperative resource utilization for pediatric appendectomies.

Methods: We searched PubMed to identify articles examining the association between surgeon specialization and outcomes for pediatric patients undergoing appendectomies. Study selection, data extraction, risk of bias assessment, and quality assessment were performed by one reviewer, with another reviewer to resolve discrepancies.

Results: We identified 4799 articles, with 98.4% (4724/2799) concordance after initial review. Following resolution of discrepancies, 16 studies met inclusion criteria. Of the studies that reported each outcome, GS and PS demonstrated similar rates of readmission within 30 days (pooled RR 1.61 95% CI 0.66, 2.55) wound infections (pooled RR 1.07, 95% CI .55, 1.60), use of laparoscopic surgery (pooled RR 1.87, 95% CI .21, 3.53), postoperative complications (pooled RR 1.40, 95% CI .83, 1.97), use of preoperative imaging (pooled RR .98,95% CI .90, 1.05), and intra-abdominal abscesses (pooled RR .80, 95% CI .03, 1.58). Patients treated by GS did have a significantly higher risk of negative appendectomies (pooled RR 1.47, 95% CI 1.10, 1.84) when compared to PS.

Discussion: This is the first meta-analysis to compare outcomes for pediatric appendectomies performed by GS compared to PS. Patient outcomes and resource utilization were similar among PS and GS, except for negative appendectomies were significantly more likely with GS.
Perspective on the Waldensians of the 16th Century from the Letters of John Calvin
Authors: Diedericks Morné
Published: May 2023

The Synod of Chanforan in 1532 can rightly be considered a turning point in the history of the Waldensians. However, the popular romanticising of the 16th-century encounter between the Waldensians and Protestants presents a skewed picture of what truly happened. This distorted picture causes neglect in research of the post-1532 history of the Waldensians and the Protestants. This article contributes to a focus shift in terms of relationships that were built between the Protestants and the Waldensians after the Synod of Chanforan in 1532. This is done by looking at the perception of John Calvin, the Reformer, and his attitude towards the Waldensians by using the correspondence in his letters as a point of departure. From the letters of Calvin, a deeper understanding develops regarding the growing relationship between the Protestants and the Waldensians. This growing relationship was noticeable when the Protestants considered the Waldensians to be the true church of Christ. After Geneva sent numerous missionary ministers to the Waldensian valleys, it was also perceptible that the relationship between the Protestants and the Waldensians had improved, especially after the founding of the Geneva Academy in 1558. Lastly, the growing relationship of Calvin with the Waldensians was also visible since he could rebuke them regarding their confessions and ecumenical attitude towards other Protestant congregations.
Who Is Attracted to the Chinese Model in Africa?
Authors: Ishiyama John
Published: May 2023

There has been much recent scholarly interest in the activities of China in Africa. Scholars have noted that China presents an alternative developmental model, that challenges the “Washington Consensus.” To what extent is this model attractive to African publics, and to whom is it attractive? Using the 2016 wave 6 Afrobarometer data, as well as data from V-Dem and other country-level economic financial aid and trade data, and using multilevel regression analysis, I find that there is little support for the idea that a country’s dependence on Chinese financial aid impacted in any way African public opinion about China as a model (although the volume of Chinese imports relative to Western imports correlates negatively with viewing China as a model). Furthermore, when considering economic versus ideological explanations, individual perceptions of China regarding economic benefits for their countries matter more than ideological attraction (or revulsion) of the China model.
Alcohol Consumption during the Covid-19 Pandemic in India
Authors: Kaicker Nidhi
Published: May 2023

The study examines the impact of Covid-19-induced economic stressors (such as incomes and job losses) on household alcohol consumption in India. Our analysis, based on eight waves of the Centre for Monitoring Indian Economy–Consumer Pyramids Household Survey (CMIE-CPHS) for the period January 2019–August 2021, confirms an increased consumption of alcohol during the pandemic despite supply restrictions imposed by the state. A spurt was witnessed across socioeconomic groups with varying intensities. This confirms the self-medication hypothesis and stress-response-dampening theory that households responded to the pandemic-related economic and psychological shocks by increasing the consumption of alcohol and is more significant for the poor and the marginalised.

JEL Codes: D12, C23
Manufacturing and testing of waste PET reinforced with sand bricks
Authors: Moulai Arbi Youcef , Mahmoudi Noureddine , Djebli Abdelkadeur
Published: May 2023

The high and increasing demand for plastic materials has led to a global challenge in the form of plastic pollution, because of the different types of discarded plastic, such as polyethylene terephthalate (PET), polypropylene (PP), and high-density polyethylene (HDPE), etc.; it has become difficult to recycle it. Thus, only a limited percentage of plastic is recycled. Many studies in this field are trying to find alternative solutions such as the introduction of plastic in building materials. This study examines brick particles as reinforcement in polyethylene as a matrix. 30%, 35%, 40%, and 45% of weighted brick sand were combined with PET and prepared by melt compounding and processed through a single-screw extruder at 260°C. Thermal properties were studied by thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC). The results show that in the presence of brick particles, the thermal degradation temperature of the composites increased. The composite that contains 45% of brick sand weight attempted 314.323°C as the highest degradation temperature, as well as the glass transition temperature. Mechanical tests show that the addition of brick in the matrix leads to a significant reduction in impact resistance. Static failure stress reaches 26.26 (MPa) in a composition of 30% of the brick sand weight. Young’s modulus shows better results in 30% of weighted brick sand equal to 2,771 (MPa). The scanning electron microscope (SEM) reveals a uniform distribution of the reinforcing charge.
Toward a Descriptive Problem-Based Taxonomy for Mental Health: A Nonmedicalized Way Out of the Biomedical Model
Authors: Cantú Arnoldo
Published: May 2023

Psychiatric diagnoses found in the Diagnostic and Statistical Manual of Mental Disorders ( DSM) and International Classification of Diseases ( ICD) are pervasive in the field of mental health to help individuals access services such as psychotherapy. In the United States, they are used for insurance reimbursement purposes and by providers in client–clinician encounters. Psychiatric disorders tend to be subsumed under the biomedical model of mental health and have been critiqued for contributing to iatrogenic harm and stigma in addition to fundamental concerns about their validity and reliability. However, current practice of requiring psychiatric diagnoses within health care systems occurs due to federal regulations and does not allow for the formal use of alternative taxonomies, forcing clinicians and clients into the biomedical model. This article will explicate key stakeholders involved and technicalities dictating the use of psychiatric diagnoses. It will introduce an organizing framework, borrowing from the field of social work accompanied by an example of how the field can move away from the biomedical model given the regulations at play. This article proposes the interdisciplinary development of an alternative nonmedicalized, psychosocial, and codified descriptive problem-based taxonomy that can decouple psychiatric diagnosis from the eligibility for and provision of mental health services.