bluuebunny/crossref_metadata_2025 huggingface dataset:
Perfil do gerente de Unidade Básica de Saúde – atribuições e desafios na perspectiva do profissional
Authors: Valério Nascimento Guimarães Flávia
Published: February 2025

Este artigo discute os achados de uma pesquisa que procurou elucidar a experiência vivida por gerentes de Unidades Básicas de Saúde (UBS) no município de Divinópolis, em Minas Gerais, na intenção de contribuir para o desenvolvimento gerencial em saúde. Tem como objetivo compreender o desenvolvimento das atribuições do gerente de Atenção Primária à Saúde (APS) a partir da perspectiva desses mesmos profissionais. Ao se tornarem gerentes, esses profissionais, muitas vezes despreparados, depararam-se com uma rotina de trabalho intensa, variada e fragmentada e se esbarram com prioridades institucionais que dificultam a implantação de suas agendas e o planejamento das atividades. Altamente dependentes de outros setores, os gerentes precisam organizar uma ampla rede de relacionamentos dentro e fora da instituição para facilitar a realização de seu trabalho. Suportando tensões, resolvendo problemas e superando desafios, eles revisaram seus conceitos e passaram por um processo de mudança de consciência que os levou a pensar e a agir como gerentes. Ser um gerente de UBS significou, para cada um deles, ser um agente de mudanças, que trabalha em um ambiente de alta pressão, liderando processos de transformação na sua unidade, em função da comunidade em que se insere.
The effect of pretreatments on the moisture content, fat content, and
acceptability of vacuum-fried white oyster mushroom (Pleurotus ostreatus) chips
Authors: Azotea A.N.B.
Published: February 2025

The study investigated the effect of pretreatments on the moisture content, fat content, and
acceptability of vacuum-fried white oyster mushroom chips. Control and four different
pretreatments (1) freezing, (2) osmotic dehydration with maltodextrin solution and
freezing, (3) steam blanching, and freezing, and (4) steam blanching, osmotic dehydration,
and freezing were used in the study. All samples were fried in coconut oil at 80°C at a
vacuum pressure of −700 mmHg for 15 mins, followed by spinning at 1420 rpm for 10
mins. The results showed that pretreatments significantly (p < 0.05) affected the moisture
content, fat content, and acceptability of the vacuum-fried white oyster mushroom chips.
Vacuum-fried white oyster mushroom chips pretreated with steam blanching, osmotic
dehydration, and freezing were found to have the lowest moisture content (0.86%). Other
pretreatments resulted in vacuum-fried white oyster mushroom chips with higher moisture
contents, still below the standard level for microbial growth. The osmotic dehydration
with maltodextrin solution and freezing pretreatment minimized the oil uptake (22.24% fat
content) of the vacuum-fried white oyster mushroom chips and was the most acceptable in
sensory evaluation. Therefore, the osmotic dehydration and freezing before vacuum frying
was the most suitable pretreatment for vacuum-fried white oyster mushroom chips.
Ginger, lemongrass, and stevia tea: antioxidant activity, alpha-glucosidase
inhibitory, and sensory quality
Authors: Puspitojati E. , Waluyo  , Rahayu N.A. , Saputra H.P.
Published: February 2025

The incorporation of medicinal plants in the food business is witnessing significant
expansion, specifically to fulfil consumer demands for functional foods and beverages.
The study developed beverages combining ginger, lemongrass, stevia, and tea. This study
aimed to identify the best components for ginger, lemongrass and stevia-infused herbal tea
that would demonstrate the highest levels of antioxidants and α-glucosidase inhibition.
The optimal ingredients were then evaluated through hedonic testing to evaluate customer
satisfaction. The pattern of α-glucosidase inhibition was also examined. The results
showed that the herbal tea formulation infused with ginger, lemongrass, and stevia
exhibited antioxidant activity and inhibited α-glucosidase activity. Integrating ginger into
the formulation could improve antioxidant activity and α-glucosidase inhibition. It can be
concluded that the most optimal tea formulation was J3D3, consisting of tea, lemongrass,
ginger, and stevia in quantities of 0.4, 0.2, 0.6, and 1.2 g, respectively. The sample had a
free radical inhibition activity of 92.68 ppm, categorizing it as a potent antioxidant.
Furthermore, the α-glucosidase inhibitory capacity of the best herbal tea was 287.65 ppm.
The sensory evaluation formulation had a sensory evaluation of taste, colour, and flavour
(specifically in the "like" category). The J3D3 exhibited an uncompetitive inhibition
pattern against α-glucosidase, significantly suppressing the enzyme's activity by forming a
complex with the substrate enzyme. This finding suggested ginger, lemongrass, and stevia
-infused herbal tea could be developed into a commercially available antidiabetic
functional beverage due to the in vitro α-glucosidase inhibitory activity.
IMPACTO DEL MANTENIMIENTO INDUSTRIAL, EQUIPO, MAQUINARIA, MATERIA PRIMA, MÉTODOS DE TRABAJO Y MANO DE OBRA EN EL NIVEL DE SIX SIGMA EN UNA PYME: ESTUDIO DEL CASO DE BLOQUERA MEDINA EN EL MUNICIPIO DE SAN PEDRO CHOLULA, PUEBLA
Authors: Medina Juan Chavez , Lopez Norma Angelica Santiesteban , Meneses José Gerardo de la Vega , Quiroz Oscar Salinas
Published: February 2025

Objetivos: Este estudio busca implementar Six Sigma en la empresa "Bloquera Medina" de San Pedro Cholula, Puebla, para reducir defectos en bloques de construcción, optimizar recursos y mejorar la competitividad en el mercado local.
 
Marco Teórico: Six Sigma, introducido por Motorola en 1987, es una herramienta de mejora continua que integra métodos como el Control Estadístico de Procesos (SPC) y la Administración de la Calidad Total (TQM). Mediante el modelo DMAIC (Definir, Medir, Analizar, Mejorar, Controlar), busca reducir variaciones para alcanzar una tasa de defectos de 3.4 por millón de oportunidades. Este estudio examina la aplicabilidad de Six Sigma en una PYME de construcción.
 
Método: Se utilizó el modelo DMAIC. En la fase de Definición se identificaron áreas problemáticas; en Medición se emplearon diagramas de Ishikawa y Pareto para analizar defectos; en Análisis se aplicaron los “5 porqués” para determinar causas raíz; en Mejora se implementaron capacitaciones y mantenimiento, y en Control se establecieron controles preventivos.
 
Resultados y Discusión: La implementación de Six Sigma redujo defectos, alcanzando un nivel de 4.01 Sigmas y una disminución del 61.44% en desperdicios. Se lograron ahorros en costos de mano de obra, materiales y equipo, aunque se enfrentaron desafíos, como la resistencia del personal al cambio.
 
Implicaciones de la Investigación: Este estudio demuestra que Six Sigma es efectivo en PYMEs de construcción, sugiriendo que esta metodología puede mejorar la competitividad en empresas pequeñas.
 
Originalidad/Valor: El estudio aporta un enfoque innovador al aplicar Six Sigma en una PYME de construcción en México, mostrando cómo pequeñas empresas pueden beneficiarse de metodologías avanzadas de calidad para reducir desperdicios y mejorar su productividad.
Research on the Curriculum Development of Red Culture Research and Practice Education Bases
Authors: Liu Guixiu
Published: February 2025

With the further deepening of ideological and political education, the importance of red culture in ideological and political education is more and more prominent, which is conducive to carrying forward the revolutionary spirit, cultivating students’ feelings of family and country, and enhancing their national pride and cultural confidence. This paper analyzes the importance of curriculum development of the red culture research practice education base, clarifies the principles of curriculum development, and puts forward the strategies of developing red culture research courses in combination with current political hot spots, cleverly integrating them into regional red culture education resources, developing red culture digital courses and carrying out red culture education in combination with the deeds of revolutionary heroes to comprehensively improve the curriculum development quality of the red culture research practice education base.
Teaching Reform and Practice of “Municipal Road Construction” Course Based on Information Technology
Authors: Hu Xiang
Published: February 2025

With the rapid development of science and technology, the cost of using information technology and the Internet is getting lower and lower, so the Internet has gradually entered thousands of households. The advantages of the Internet in education and teaching are gradually explored by educators. The use of information technology to carry out teaching this new teaching method is gradually popularized. The rich teaching resources on the network in the classroom fully mobilize the students’ interest in learning, so the classroom teaching effect has been significantly improved. Taking the “Municipal Road Construction” course as an example, this paper briefly expounds the concept of information technology and its role in municipal road construction and the necessity of information technology reform in this course, and puts forward some teaching reform measures according to the current education and teaching status, to provide support for the teachers of “Municipal Road Construction” course in colleges and universities.
Analysis of Opportunities, Challenges and Paths of Ideological and Political Education in Colleges and Universities in the Era of All-media
Authors: Jiang Xin
Published: February 2025

The all-media era is a big trend. The development of all-media technology has a profound impact on the internal and external environment of ideological and political education in colleges and universities. On the one hand, the time and space “all-weather,” the way “diversified,” the main body “extensive” provide opportunities for ideological and political education in colleges and universities. On the other hand, the “quantification” of information, the “slicing” of thinking and the “vagueness” of value have brought realistic difficulties to the ideological and political education in colleges and universities. Therefore, ideological and political education in colleges and universities should innovate content methods, improve media literacy, strengthen the construction of teachers, establish multiple platforms, strengthen platform supervision and other aspects to seek advantages and avoid disadvantages, and promote the high-quality development of ideological and political education in colleges and universities.
Exploration of Teaching Reform Path of Exhibition Service and Management Major in Secondary Vocational Schools from the Perspective of Curriculum Ideology and Politics
Authors: Zong Ziyi
Published: February 2025

Under the background of carrying out the basic task of moral education and cultivating people in secondary vocational schools, the rise and development of curriculum ideological and political education concepts provide a clear direction for the reform of various courses in secondary vocational schools. Exhibition service and management major is an important part of the secondary vocational education system. Colleges should pay attention to carrying out ideological and political education in teaching, excavating the ideological and political education elements contained in the curriculum, and giving full play to the coordinated education effect. Based on this, this paper studies the ideological and political teaching reform of exhibition service and management major in secondary vocational schools. Firstly, it analyzes the problems existing in the implementation process of ideological and political education in the curriculum, and then puts forward specific optimization strategies, aiming at providing reference for the reform of ideological and political teaching in the curriculum.
The Integration of Information Technology and Physical Education Professional Course Teaching in Colleges and Universities: Technology Empowers Modern Sports
Authors: Wang Wenjun , Aldana Padua Shirley
Published: February 2025

This paper adopts the literature data method, content analysis method and logical induction method. This paper analyzes the application of information technology in universities. To summarize the problems existing in the application of information technology in physical education teachers, it is concluded that modern information technology is an effective auxiliary means of physical education professional course teaching in colleges and universities. The application of modern information technology has changed the learning style of college PE students and enhanced their interest in learning. The teaching of physical education in universities is the embodiment of teachers’ information technology literacy, physical education knowledge and teaching organization and management ability. Modern information technology has increased the inclusiveness of professional physical education course teaching in colleges and universities. The application of modern information technology in the teaching of college physical education specialized courses should adhere to the principle of moderation.
Innovative Exploration and Design of Ideological and Political Education in the “Analog Electronic Technology” Course
Authors: Li Xiangyu
Published: February 2025

Taking moral education and war education as the fundamental task and the soul of the course, based on the “Guiding Outline of Curriculum Ideological and Political Construction” in colleges and universities, the study constantly explores and practices the curriculum ideological and political simulation of electronic technology. The course group mainly explores the potential ideological and political elements from the “three levels,” pays attention to the “four dimensions” of the overall design of the course ideological and political content, pays attention to the high unity of knowledge imparts, ability training and value guidance, gives full play to the main position of the course in the training of electronic professionals, and the ideological and political course in the same direction and frequency, training revolutionary soldiers in the new era.
The Revolutionary Role of Virtual Reality Technology (VR) in Architectural Design Review
Authors: Xie Bing
Published: February 2025

Virtual Reality (VR) technology has gradually become an indispensable tool in the field of modern architectural design. This study explores the revolutionary role of virtual reality technology in the architectural design review process. By analyzing the application cases of VR technology and its practical effects in design review, this paper mainly proposes that VR technology can not only enhance the efficiency of communication between designers and clients, but also improve the visualization effect of the design scheme and the comprehension of space. This paper begins with the limitations of the traditional process of architectural design review and reveals the challenges it faces. It then introduces the basic principles of VR technology and its specific applications in architectural design, especially the advantages in the design review stage. Case studies of actual projects are analyzed to discuss in detail how VR technology can help design teams and stakeholders understand and evaluate design solutions more directly, thus accelerating the decision-making process and reducing design modifications and rework in the construction phase. The study summarizes the current status of the application of VR technology in the field of architectural design and looks forward to its future development trend, emphasizing the importance of continuous technological innovation and multidisciplinary cooperation. This paper argues that with the continuous progress and popularization of VR technology, it will play a revolutionary role in architectural design review, completely change the traditional design review method, and promote the overall development of the construction industry.
Research on the Teaching Reform of Garment Pattern Design and Technology Course in Higher Vocational Education in the Internet Age: The Integration of Virtual Simulation Technology and Traditional Culture
Authors: Wang Tingwei , He Qingyuan
Published: February 2025

In the context of the Internet era, modern technology has advanced rapidly, with the integration of digital intelligence emerging as a significant trend in the reform of higher vocational education and teaching. This paper uses the higher vocational clothing design and technology major as a case study. It first analyzes the current state of the discipline within the Internet era, and then explores the significance and pathways of integrating virtual simulation technology into the teaching of traditional cultural elements in clothing pattern design and technology courses. The purpose of this paper is to drive educational reform in vocational clothing design further, providing robust support for the sustainable development of the fashion design industry.
Study on the Clinical Effects of Neurology Nursing in the Rehabilitation Process of Stroke Patients
Authors: Wang Lijing , Yang Jiao , Deng Hongyu , Guo Chuo , Lu Jiazhen
Published: February 2025

Objective: To explore the clinical effects of neurology nursing during the rehabilitation process of stroke patients. Methods: A total of 80 inpatients with stroke, admitted between July 2023 and July 2024, were selected for the study. They were randomly divided into two groups of 40 patients each. The control group received conventional nursing care, while the study group was provided with neurology nursing. The nursing outcomes of the two groups were compared in terms of: (1) rehabilitation progress, (2) nursing satisfaction, (3) psychological status, and (4) self-care ability. Results: The nursing efficacy and satisfaction rates in the study group were significantly higher than those in the control group (P < 0.05). Pre-intervention psychological scores showed no significant differences between the two groups (P > 0.05). Post-intervention, negative emotions in both groups were alleviated, with the study group showing greater improvement compared to the control group (P < 0.05). Additionally, the self-care ability scores of the study group were significantly higher than those of the control group (P < 0.05). Conclusion: Neurology nursing during the rehabilitation process of stroke patients demonstrated ideal clinical effects, positively contributing to patient recovery, alleviating negative psychological states, and proving beneficial for promotion.
Study on the Effect of Coal Bed Water Injection Wetting Enhancer on the Wettability of Hongliulin Bituminous Coal
Authors: Liu Zhuang
Published: February 2025

A coal seam water injection wettability enhancer was developed through surfactant compounding to enhance water injection and dust suppression in underground coal seams of coal mines. The enhancer, comprising an anionic surfactant (SAS-60) and a nonionic surfactant (APG), was evaluated for its impact on the wettability of Hongliulin bituminous coal using surface tension, contact angle, and Fourier transform infrared spectroscopy tests. The results revealed that the surface tension of the coal seam water injection wetting agent (AS) was 26.51 mN/m with a contact angle of 26.66°. Furthermore, AS demonstrated superior wetting properties by exhibiting optimal peak area and percentage of hydroxyl structures, thereby significantly enhancing the wetting properties of coal dust. These findings offer valuable insights for mitigating coal mine dust and developing effective coal seam water injection wettability enhancers.
The Relationship between Parenting Style and Social Behavior: A Systematic Review and Meta-analysis
Authors: Zheng Weiming , Xu Jinhui , Zhang Qian
Published: February 2025

Given that evidence for meta-analysis on the association between parenting style and social behavior has been relatively sparse, this research will provide useful information for the field. This article presents a meta-analysis of the association between parenting style and social behavior in Chinese children. A total of 47 eligible studies with 98 independent effect sizes (54,448 participants) were included in this meta-analysis. First, the study conducted a random-effects meta-analysis to assess the association between parenting style (positive vs. negative) and social behavior (prosocial vs. aggressive). Next, the study performed moderation analyses based on the meta-regression analyses for the continuous variable (sex ratio) and the Q statistics for categorical variables of the publication period (i.e., development period, COVID-19 period). Results were that positive parenting style was positively correlated with prosocial behavior (r = 0.24, 95%CI[0.17,0.31], P < 0.001), whilst negative parenting style was negatively correlated with prosocial behavior (r = -0.10, 95%CI[-0.13,-0.06], P < 0.001). Positive parenting style was negatively correlated with aggressive behavior (r = -0.17, 95%CI[-0.21,0.-12], P < 0.001), whilst negative parenting style was positively correlated with aggressive behavior (r = 0.23, 95%CI[0.15,0.30], P < 0.001). These findings suggest that a positive parenting style should be applied as much as possible to shape children’s prosocial behavior, whilst a negative parenting style should not be applied to avoid aggressive behavior.
A Review on the Deep Integration of Culture and Tourism Promoted by Big Data
Authors: Li Yue
Published: February 2025

Under the background of the digital era, the development of deep integration of culture and tourism promoted by big data has attracted more and more attention from the academic circle. This paper reviews relevant literature on the deep integration of culture and tourism promoted by big data. This paper summarizes the main topics of related research from the aspects of the relationship speculation and internal logic of cultural tourism, the integrated development of the cultural tourism industry enabled by digital technology, and the application of big data to promote the deep integration of cultural tourism. Combined with the above development trends, this paper proposes the research prospect of promoting the deep integration of cultural tourism in the digital era from the aspects of basic concept research, research content, and research methods.
DESENVOLVIMENTO PROFISSIONAL DOCENTE EM ESCOLAS BILÍNGUES: UM PANORAMA DAS PESQUISAS BRASILEIRAS
Authors: Bihringer Katiúscia Raika Brandt , Tomio Daniela
Published: February 2025

Um crescente número de escolas denominadas “bilíngues” vem sendo implementadas nos últimos anos no Brasil. Dada as especificidades das práticas educativas, em sua relação com a linguagem, é necessário refletir os percursos de formação e de identidade dos profissionais que atuam nessa realidade. Por meio de um estado da questão, objetivamos caracterizar o Desenvolvimento Profissional Docente (DPD) em interface às práticas sociais de linguagem (translinguagem) em escolas bilíngues investigadas na produção científica brasileira. O corpus de análise constituiu-se de 67 pesquisas de mestrado e doutorado, analisadas considerando os tópicos emergentes de investigação e, mais especificamente, as pesquisas que tratam a formação docente em escolas bilíngues em perspectiva à translinguagem. Concluímos que há uma urgência de pesquisas sobre desenvolvimento profissional nesses contextos, que possibilite refletir novas perspectivas para investigação das escolas bilíngues, como espaço social que integram dimensões profissionais de identidade e prática.
Spatial Analysis of Stunting Incidents in Toddlers in The City of Tasikmalaya 2023
Authors: Annisa Nabila Nur , Setiadi Dedi , Radiati Ani , Sukawan Ari
Published: February 2025

Kesehatan memegang peranan penting dalam menjaga kelangsungan hidup. Indonesia menghadapi beban ganda terkait gizi anak, salah satunya adalah stunting . Metode yang efektif dalam memfokuskan upaya penanggulangan stunting adalah analisis spasial. Cara ini dapat memudahkan pengambilan keputusan dan perumusan kebijakan dalam mengatasi permasalahan kesehatan ini. Tujuan penelitian ini adalah untuk mengetahui sebaran kasus stunting pada balita dengan menggunakan metode analisis spasial di Kota Tasikmalaya pada tahun 2023. Metode penelitian ini adalah kuantitatif dengan desain penelitian deskriptif. Penelitian ini menggunakan data sekunder yang melibatkan total populasi 4.767 balita. Berdasarkan hasil penelitian digambarkan Puskesmas Kawalu memiliki prevalensi stunting tertinggi , sedangkan Puskesmas Cipedes memiliki prevalensi stunting terendah pada tahun 2023. Dilihat dari usia balita, stunting lebih banyak terjadi pada rentang usia 0- 59 bulan dibandingkan pada rentang usia 0-23 bulan. Berdasarkan jenis kelamin, balita laki-laki mempunyai prevalensi stunting lebih tinggi dibandingkan balita perempuan. Dengan menggunakan metode analisis spasial, hal ini memberikan kontribusi signifikan terhadap peningkatan efektivitas intervensi kesehatan.
Group Decision Support System (GDSS) Model on Software Engineer Selection: Integration of AHP,SAW, TOPSIS, and BORDA
Authors: Sari Tika Novita , Astriratma Ria , Mulyana Sri
Published: February 2025

One of the requirements for any company's success is the efficient utilization of human resources in its operations. There are several different tasks that fall within the Human Resources Management (HRM) role. This study uses the GDSS technique, combining TOPSIS for the second decision maker and AHP-SAW for the first decision maker. There are two decision makers (DMs), as is the case. After that, each decision maker's ranking will be processed using the BORDA technique. This study concludes that there are differences in the outcomes from DM1 and DM2. This is a result of the propensity for every decision-maker to offer a unique assessment. While DM2 employs the scoring technique using percentages to determine sub-parameter weighting and the TOPSIS method for ranking, DM1 uses the AHP method for sub-parameter weighting and SAW for ranking. However, the researchers integrated the two decision makers with a group decision support system utilizing the BORDA approach, accounting for the decision makers' respective levels of interest. The findings highlight the significant contribution of this research in demonstrating how the integration of these methods effectively addresses differences in evaluation approaches among decision-makers, particularly in the context of software engineering, ensuring a transparent and data-driven selection process. The GDSS model was tested on a case study of software engineer selection, demonstrating a high level of accuracy in identifying the most suitable candidates for organizational needs. Furthermore, the results of the GDSS aligned with the decisions made by the case study company, validating the effectiveness of the proposed model. The practical application of this model can be adopted by companies to enhance the efficiency and quality of recruitment processes.
Segmentasi Berbasis Warna Untuk Pengelompokan Kualitas Cacing Anc Menggunakan Yolov8
Authors: Nurdiyansyah Firman , Akbar Ismail , Ursaputra Lionardi
Published: February 2025

Mengembangkan metode otomatisasi dalam pengelompokan kualitas cacing African Night Crawler (ANC) menggunakan model YOLOv8 yang didukung oleh segmentasi berbasis warna. Metode manual yang selama ini digunakan dalam menilai kualitas cacing sering kali memakan waktu dan cenderung tidak konsisten, sehingga pendekatan berbasis teknologi diperlukan untuk meningkatkan efisiensi dan akurasi. Penelitian ini dimulai dengan pengumpulan dataset gambar cacing ANC, yang kemudian dianotasi berdasarkan tiga kelas utama, yaitu merah, putih, dan putih-biru. Dataset ini diproses melalui langkah-langkah preprocessing untuk memastikan kualitas data yang konsisten, kemudian dibagi menjadi training set (80%), validation set (15%), dan test set (5%). Model YOLOv8 diterapkan untuk mendeteksi dan mengklasifikasikan objek, dengan arsitektur yang terdiri dari Backbone, Neck, dan Head yang dirancang untuk mengoptimalkan deteksi multi-skala. Hasil penelitian menunjukkan bahwa model YOLOv8 memiliki performa yang sangat baik, dengan mean Average Precision (mAP) rata-rata sebesar 93.8% pada training set, 94.0% pada validation set, dan 95.0% pada test set. Nilai precision mencapai 95.6% pada training set, sementara recall mencatat 85.4%, menghasilkan F1-Score sebesar 90.3%. Hasil ini menunjukkan bahwa model tidak hanya akurat dalam mendeteksi objek yang relevan tetapi juga memiliki sensitivitas yang baik terhadap variasi data. Kesimpulannya, penggunaan YOLOv8 untuk segmentasi berbasis warna pada cacing ANC memberikan solusi yang efisien dan akurat dalam mengklasifikasikan kualitas cacing. Selain mendukung otomatisasi dalam industri peternakan, penelitian ini juga membuka peluang penerapan lebih lanjut dalam sektor agrikultur lainnya, dengan rekomendasi untuk meningkatkan generalisasi model pada variasi data yang lebih kompleks di kondisi dunia nyata.
Repositórios de Dados Abertos de Pesquisa em plataformas de universidades brasileiras
Authors: Rodrigues Adriana Alves , Dias Guilherme Ataide
Published: February 2025

A pesquisa teve como objetivo descrever e analisar os aspectos técnicos dos repositórios de dados de pesquisa vinculados às Instituições de Ensino Superior (IES) no Brasil. Para isso, realizou-se pesquisa exploratória e uma análise descritiva a partir do site Re3data, um dos principais diretórios de registro de dados globais de pesquisa. Foram analisados oito repositórios a partir das categorias: software, acesso aberto, licenças e padrão de metadados. Os resultados sugerem que estes aspectos podem apresentar vantagens por parte dos pesquisadores em realizar pesquisas frequentes nestes repositórios, por um lado, e por outro, podem acarretar inúmeras discrepâncias ao realizar suas coletas, compartilhamento, reutilização e encontrabilidade dos dados quando não estão bem gerenciados.
समकालीन हिंदी नाटक:विषय वस्तु की समकालीनता
Authors: Rai Shashikant
Published: February 2025

समकालीन विषय वस्तु की समकालीनता में बहुत से कारण जिम्मेदार है, पहली बात तो यह है कि वैश्विक उथल-पुथल से हमारा देश भी प्रत्यक्ष या अप्रत्यक्ष रूप से प्रभावित होता रहा है। जिस कारण मानवीय संवेदना का बहुत तेजी से स्वरूप विकसित हुआ 19वीं शताब्दी में पश्चिमी संस्कृति से जब हमारा साक्षात्कार हुआ तो उससे भी हमारा जीवन निश्चित रूप से प्रभावित हुआ और साथ ही साथ उस दौर के भारतीय बुद्धिजीवियों में भी परिवर्तन की वैचारिकी वैश्विक परिदृश्य के साथ सामने आयी।
समकालीन हिंदी नाटक की पृष्ठभूमि
Authors: Rai Shashikant
Published: February 2025

समकालीन भावबोध बनने में वस्तु(सत्त्ता) की बाह्य एवं आंतरिक दोनों तत्वों की महत्वपूर्ण भूमिका होती है। साहित्य और समाज एक दूसरे के पूरक है। समाज को देखने समझने के जो दृष्टिकोण है, उसमें बड़ा भारी परिवर्तन हुआ। मसलन समाज की आर्थिक व्यवस्था को केंद्र में रखते हुए मार्क्सवादनेसमझाने का एक नया दृष्टिकोण दिया। मार्क्स के अनुसार समाज की अर्थव्यवस्था आधार होती है और राजनीति, धर्म, संस्कृति अथवा दर्शन ऊपरी ढांचा। जैसे-जैसे आधार में परिवर्तन होता जाता है, वैसे-वैसे सामाजिक ढांचा में भी परिवर्तन हो जाता है। वही एक और पश्चिम के विद्वान 'तेन' महोदय ने वैज्ञानिक दृष्टिकोण से साहित्य को समझने की बात कही। उन्होंने माना कि रचना या घटना की व्याख्या करने के लिए जाति, वातावरण, और क्षण इन तीनों का महत्वपूर्ण योगदान होता है।
THE INTERTWINING OF ECO-SPIRITUALITY AND NON-HUMAN VOICES: A STUDY OF SELECTED POEMS FROM TED HUGHES’ CAVE BIRDS
Authors: Dhariwal Jaibir
Published: February 2025

Ted Hughes’ Cave Birds emerges as a profound poetic exploration of the spiritual and environmental crises afflicting humanity in the 21st century. By intertwining eco-spirituality and non-human voices as material agency, Hughes crafts an alchemical drama that critiques anthropogenic cultural attitudes and highlights humanity’s estrangement from the natural world. Hughes’ spiritual belief in the sanctity and materiality of natural world has its own logic and validity. Tracing his deep awareness about ecological degradation, his poems treat the spiritual and environmental crisis as one. The poetry of Ted Hughes is fundamentally pitched against anthropocentrism, the root cause of environmental and spiritual crisis across the globe. Aligned with material ecocritical perspective, Hughes employs non-human voices to embody the agency of nature, challenging the anthropocentric perspective that places humanity at the centre of existence. Non-human entities in the poems serve not merely as metaphors but as active participants in a broader eco-spiritual dialogue, challenging the dominance of human-centric worldviews. This study explores how Hughes draws upon the ritualistic indigenous traditions to offer a critique of anthropocentric values and the mechanistic mindset of modernity while proposing an alternative vision of coexistence rooted in interconnectedness and harmony. Hughes envisions nature as both a victim and a healer, capable of offering relief to humanity’s spiritual and ecological disarray. Ultimately, Cave Birds serves as a poetic response to the ailing humanity of the 21st century, advocating for a reawakening of eco-spiritual consciousness as a path to both ecological and spiritual restoration.
Prospects for the application of nanotechnology in the development of antitumor drugs
Authors: Seliverstov P.V. , Ananyan M.A. , Marchenko S.D. , Stepanov M.R. , Voznesenskaya E.A. , Ilina K.V. , Lyapustin K.Yu.
Published: February 2025

Introduction. Nanotechnology represents an innovative direction in cancer drug development, enabling the creation of effective drug delivery systems with enhanced therapeutic properties. Objective. To analyze the main types of nanoparticles used in oncology, evaluate their clinical effectiveness, and identify promising directions in nanotechnology development for cancer therapy. Material and methods. Analysis of current scientific publications on the development and application of various types of nanoparticles in oncology, including clinical trial data and approved drugs. Results. The physicochemical properties and therapeutic potential of liposomal, polymeric, and metallic nanoparticles are examined. Analysis of clinically approved nanomedicines and promising developments is presented. Ethical and regulatory aspects of nanotechnology applications in oncology are discussed. Conclusion. Nanotechnology demonstrates significant potential in improving cancer therapy effectiveness. The development of “smart” nanomaterials, integration with CRISPR technologies, and creation of multifunctional nanosystems represent the most promising research directions.
Efficacy of antitumor therapy schemes with carboplatin in an experimental model of lung carcinoma and drug-resistant tuberculosis
Authors: Kudriashov G.G. , Krylova Yu.S. , Zmitrichenko Yu.G. , Tochilnikov G.V. , Agafonov G.M. , Vinogradova T.I. , Yablonskii P.K.
Published: February 2025

Introduction. Up to 20% of tuberculosis patients suffer from malignant neoplasms. In this case, the combination of both diseases in the lung is a particular problem. More than 60% of patients cannot complete combination therapy due to drug-resistant MBT. The aim of the study was a preclinical study of the efficacy and safety of combination regimens of antitumor therapy using carboplatin and antituberculosis therapy for drug-resistant tuberculosis. The study was supported by grant No.22-15-00470 from the Russian Science Foundation (https://rscf.ru/project/22-15-00470/) Material and methods. The study was conducted on 40 C57BL/6 mice aged two months with pre-modeled combined pathology of lung carcinoma and tuberculosis. Depending on the therapy, 4 groups were formed: I – control without treatment (n = 10), II – antitumor (carboplatin + paclitaxel) + antituberculosis therapy (n = 10), III – antitumor (carboplatin + pemetrexed) + antituberculosis therapy (n = 10), IV – antitumor (carboplatin + gemcitabine) + antituberculosis therapy (n = 10). The antituberculosis therapy regimen included moxifloxacin, linezolid, bedaquiline and perchlozone. The antitumor effect (tumor growth index, tumor growth inhibition), antituberculosis effect (CFU per lung weight), toxicity (biometric parameters of internal organs), and survival were assessed. Statistical processing was performed using non-parametric statistics methods. Results. The lowest average body weight was recorded in the control group. The average body weight of the experimental animals correlated with the tumor node volume. The smallest tumor volume was recorded in the control, and the largest in group IV. The optimal anti-tuberculosis effect was achieved in all experimental groups. At the same time, significantly better survival, as well as signs of lower toxicity were noted in the group where anti-tuberculosis therapy was used in combination with carboplatin and gemcitabine. Conclusion. A preclinical study of the efficacy and safety of combined anti-tuberculosis and antitumor therapy with carboplatin based on a combination model of Lewis pulmonary carcinoma and drug-resistant tuberculosis showed an optimal anti-tuberculosis effect in all groups. At the same time, acceptable toxicity and better survival indicate a greater safety of the combination of anti-tuberculosis therapy with carboplatin and gemcitabine.
Sensitization profile of adult patients with allergic bronchial asthma in the Rostov region
Authors: Churyukina E.V. , Ukhanova O.P. , Kotieva I.M. , Dodokhova M.A. , Gulyan M.V. , Avilov А.V. , Koreeva E.V.
Published: February 2025

Introduction. Bronchial asthma is a heterogeneous disease involving different phenotypes. The allergic phenotype is the most studied model of asthma. Identification of causally significant allergens by determining allergen-specific IgE is the key to precision medicine in allergy. Microchip technology makes it possible to analyze the molecular profiles of sensitization of patients with allergies, identify major allergens, and develop personalized approaches to allergenic immunotherapy. Objective: to evaluate the sensitization profile in adult patients with allergic bronchial asthma in the Rostov region of southern Russia using molecular allergodiagnostics. Material and methods. In an open multicenter retrospective cohort non-randomized study, individual maps of 166 adult patients with a verified diagnosis of bronchial asthma who underwent molecular allergodiagnostics using the Allergy Explorer 2 (ALEX2) allergochip method were analyzed. Statistical processing of the results was carried out using the Microsoft Office Excel 2010 and Statistica 10.0 for Windows software package. Results. According to the results of the study, polysensitization prevails among adult patients with an allergic asthma phenotype, and the leading value of pollen sensitization has been established. The dominant, clinically significant pollen allergens in 100% of cases are weeds (in 41.0% of the examined), among which the major allergen ambrosia Amb a 1 (43.98%) prevails, followed by wormwood Art v 1 (23.49%). In most cases, tree pollen determines subclinical sensitization in 77.7% of patients and causally significant in only 22.3%. The high frequency of sensitization to cross-reactive molecules causes IgE-mediated reactions to plant products (fruits [43.4%], nuts [30.7%]), latex [21.7%]). Conclusion. The study allowed us to establish the spectrum of sensitization of adult patients with allergic asthma phenotype, revealed the predominant causally significant role of weed pollen allergens in the development of seasonal pollen allergy in the Rostov region, determined the causally significant major molecules of pollen sensitization, which is important for the correct selection of patients for allergenic immunotherapy in the future.
COVID-19 IN THE CENTRAL NERVOUS SYSTEM: ROUTES OF ENTRY AND INFLUENCE ON GLIOMAGENESIS
Authors: Mitrofanova L.B. , Makarov I.A. , Guseva K.A. , Danilova I.A. , Gulyaev D.A.
Published: February 2025

Introduction. The pathogenesis of infection of the central nervous system (CNS) with SARS-CoV2 and nervourological complications are still poorly understood, as well as the link of viral infection with the risk and the course of gliomas. The aim. Evaluating of the possible involvement of Basigin, NRP1, Cathepsin L and transmembrane proteases TMPRSS2 and TMPRSS4 in coronavirus infection of neurons and gliomagenesis. Мaterial and methods. histological and immunohistochemical researches with antibodies to Cathepsin L, TMPRSS2, TMPRSS4, NRP1, Vasidin, SARS-CoV-2 of the brain of 6 patients with COVID-19, 3 patients of the «precovid period» (control group) and gliomas of 7 patients operated in 2024. The results of the research demonstraded that the expression of Basigin and TMPRSS2 was significantly higher in the group of patients with gliomas compared with the other groups (for Basigin pgliomas / COVID-19 = 0.006; pgliomas / control group = 0.038; for TMPRSS2 pgliomas / COVID-19 = 0.040; pgliomas / control group = 0.006). In the group of patients with COVID-19, a negative correlation was found between the prevalence of Cathepsin L and SARS-CoV-2 expression (rs = -0.37, p = 0.009), and Basigin was expressed in 5–25% of glial cells. Cathepsin L and TMPRSS4 demonstrated moderate negative associations in the groups of patients with COVID-19 and gliomas. Conclusion: Basigin, NRP1, Cathepsin L, TMPRSS2 and TMPRSS4 cannot be used as alternative pathways for more effective penetration of SARS-CoV-2 into neurons. The expression of Basigin and TMPRSS2 was the highest in gliomas significantly. Probably, the coexpression of the virus with Basigin weakens the immunosuppression of tumors; it mays to increase the incidence or recurrence of tumors in patients with COVID-19.
MONOAMINE OXIDASE AS A TARGET FOR THE DEVELOPMENT OF NEW DRUGS
Authors: Romanycheva A.A. , Fedorov V.N. , Shetnev A.A. , Korsakov M.K.
Published: February 2025

Monoamine oxidase (MAO) is an FAD-dependent enzyme essential for regulating neurotransmitter levels and protecting the body from the harmful ef-fects of amines. Dysregulated MAO activity, through either overexpression or excessive activation, has been linked to diverse pathological conditions. Emerging evidence highlights MAO as a key contributor to oxidative stress, driving significant damage not only to the nervous system but also to the cardiovascular system. Additionally, MAO is implicated in tumor progression and metastasis. Targeting MAO through chemical inhibition offers promising therapeutic avenues for treating neurodegenerative disorders, cancer, heart failure, rheumatoid arthritis, multiple sclerosis, and other inflammatory diseases. Potential applications also extend to addressing migraines, dizziness, attention deficit disorders, diabetes, obesity, muscular dystrophy, and metabolic dysfunctions. This review summarizes current methodologies for assessing MAO activity and inhibition, alongside in vivo models used to study neurodegenerative diseases, providing a foundation for future therapeutic strategies. The article was prepared within the framework of the State assignment of the Yaroslavl State Pedagogical University named after K.D. Ushinsky for 2024 from the Ministry of Education of the Russian Federation on the topic "Development of a new drug for the treatment of neurodegenerative diseases based on a monoamine oxidase inhibitor" (registry entry number 720000Ф.99.1.БН62АА12000).
THE AMINO ACID COMPOSITION OF PHLOJODICARPUS SIBIRICUS (STEPH. EX SPRENG.) KOSO-POL.
Authors: Nikolaev Yu.N. , Taraskina A.S. , Gulyaev S.M. , Achituev V.A. , Tykheev Zh.А. , Taraskin V.V.
Published: February 2025

Introduction. Phlojodicarpus sibiricus is a valuable plant raw material – a source of coumarins, on the basis of which effective dosage forms (dry ex-tracts, tinctures) for the treatment of neurodegenerative diseases have been created. The chemical composition of the plant is well studied, but there is no information about the composition of amino acids in both aboveground and underground parts of plants. The aim of the study is to determine amino acid composition and their content in the herbs, roots and rhizomes of Phlojodicarpus sibiricus from dif-ferent habitats. Material and methods. The object of the study are herbs, roots and rhizomes of Phlojodicarpus sibiricus, collected in 2020, 2022, and 2023 during the fruiting phase from different populations in the Republic of Buryatia and Trans-Baikal Territory. Analytical samples were obtained by the quartering method. The amino acid composition and content were determined according Russian National Standard R 55569-2013 using the capillary electrophore-sis system "Kapel-105". Results. 20 amino acids have been found in grass and rhizomes and roots, of which 8 are essential. The total content of 20 amino acids in the under-ground organs of plants was in the range of 31,62–48,80 mg/g of dry weight, of which the share of essential acids accounted for an average of up to 23% (about 39 mg/g). In the herb, these values were up to 2,5 times higher than in the rhizomes and roots. Conclusion. In this regard, we have studied for the first time the composition and amino acid content of grass, rhizomes and roots of Siberian bulb-ous fruit from different populations of the Republic of Buryatia and the Trans-Baikal region. The obtained results supplement the existing information on the chemical composition of valuable raw materials and can be used in the future for development of medicines and biologically active suplements based on Phlojodicarpus sibiricus.
ONE-CARBON METABOLISM MARKERS IN CARDIAC PATIENTS AT DIFFERENT TIMES AFTER A NEW CORONAVIRUS INFECTION
Authors: Evteeva D.A. , Gaikovaya L.B.
Published: February 2025

Introduction. The development of postCOVID syndrome is accompanied by changes in one-carbon metabolism and the development of cardiovascu-lar diseases in patients who have undergone a new coronavirus infection. To understand the pathogenesis of postCOVID syndrome in patients with cardiological pathology, it is important to study possible biochemical changes, as well as to search for predictors to assess the risk of cardiovascular pathology. Objective – to evaluate changes in homocysteine and folic acid levels at different times after a new coronavirus infection in patients with cardiovas-cular diseases. Material and Methods. The case-control study included 82 patients of the cardiology department, of which 49 patients at different times after COVID-19 (6 months, 12 months and 24 months) and 33 patients without a history of COVID-19 (control). Serum concentrations of homocysteine and folic acid were determined in all patients. Results. In cardiac patients with COVID-19, regardless of the prescription period, the concentration of homocysteine was 11.1 [9.3; 14.2] mmol/l, in the control – 13.9 [12.0; 16.9] mmol/l (p=0.013). At the same time, the folic acid content in the group of patients who underwent Covid-19 was statistically significantly lower than in the group of patients who did not have COVID-19 (6.52 [4.26; 8.86] and 11.0 [8.08; 12.3] ng/ml, respectively). When analyzing homocysteine levels depending on the prescription period after COVID-19, after 6 months, the homocysteine level was 9.4 [8.3; 13.7] mmol/l, after 12 months – 10.3 [9.2; 10.6] mmol/l, after 24 months – 13.2 [11.2; 17.2] mmol/l, p=0.004. The concentration of folic acid in patients 6 months after COVID-19 was 6.13 [3.36; 8.68] ng/ml, after 12 months – 10.1 [5.63; 16.1] ng/ml, after 24 months – 5.82 [5.44; 8.06] ng/ml, p=0.08. At the time 24 months after the COVID-19, the homocysteine/folic acid ratio was higher than at other times, indicating an imbalance in one-carbon metabolism. Conclusion. Hyperhomocysteinemia is observed in patients with cardiovascular pathology, regardless of the coronavirus infection. After COVID-19 in patients with a cardiological profile, disorders in single-carbon metabolism, manifested by folic acid deficiency and hyperhomocystenemia, underlie the development of long COVID and are predictors of cardiovascular complications.