bluuebunny/crossref_metadata_2025 huggingface dataset:
Unravelling Li-ion Storage Capability of Cobalt Oxide Anode Recovered from Spent LiCoO2 Cathode via Carbothermal Reduction
Authors: Bhar Madhushri , Vishwakarma Vivek , Yalamanchili Kaliprasad , Martha Surendra K.
Published: August 2023

With the advent of globalization, the upsurge of lithium-ion battery (LIB) production and generation of spent batteries impose a severe threat as hazardous e-waste and resource sustainability of crucial elements like cobalt and lithium. Herein, we propose one-step regeneration of cobalt oxide (RCO) from cycled LiCoO2 (LCO)-type cathode via carbon anode-assisted reduction. The inherent structural changes resulting in high irreversibility are minimized in conversion-type mixed-phase recycled cobalt oxide anode due to less Li-ion consumption and stable SEI formation during initial cycles. Replacement of conventional Cu-foil current collector with carbon-fiber (CF) based freestanding electrode further enhances the Li-ion storage capacity with overall active material utilization, accommodating volume changes in the internal void spaces and providing mechanical stability. Electrochemistry reveals that RCO@CF and RCO@Cu deliver an initial discharge capacity of 3800 mAh g−1 and 1432 mAh g−1 at 30 mAg−1 with 77% and 64% coulombic efficiency that becomes ∼97% in the following cycles. Besides, RCO@CF shows an average discharge capacity of 730 mAh g−1 at 300 mA g−1 over 300 cycles, which is ∼2.7 times that of recycled graphite anode (270 mAh g−1). The sustainable recycling strategy described herein rejuvenates the cycled LCO-type cathode as an appealing anode material for LIBs.
Table S1 from HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non–Small Cell Lung Cancer
Authors: Yonesaka Kimio , Tanizaki Junko , Maenishi Osamu , Haratani Koji , Kawakami Hisato , Tanaka Kaoru , Hayashi Hidetoshi , Sakai Kazuko , Chiba Yasutaka , Tsuya Asuka , Goto Hiroki , Otsuka Eri , Okida Hiroaki , Kobayashi Maki , Yoshimoto Ryoto , Funabashi Masanori , Hashimoto Yuuri , Hirotani Kenji , Kagari Takashi , Nishio Kazuto , Nakagawa Kazuhiko
Published: August 2023

Hallmarks of pretreatment samples with/without HER3 augmentation
Data from HER3 Augmentation via Blockade of EGFR/AKT Signaling Enhances Anticancer Activity of HER3-Targeting Patritumab Deruxtecan in EGFR-Mutated Non–Small Cell Lung Cancer
Authors: Yonesaka Kimio , Tanizaki Junko , Maenishi Osamu , Haratani Koji , Kawakami Hisato , Tanaka Kaoru , Hayashi Hidetoshi , Sakai Kazuko , Chiba Yasutaka , Tsuya Asuka , Goto Hiroki , Otsuka Eri , Okida Hiroaki , Kobayashi Maki , Yoshimoto Ryoto , Funabashi Masanori , Hashimoto Yuuri , Hirotani Kenji , Kagari Takashi , Nishio Kazuto , Nakagawa Kazuhiko
Published: August 2023

AbstractPurpose:
EGFR-tyrosine kinase inhibitor (TKI) is a standard first-line therapy for activated EGFR-mutated non–small cell lung cancer (NSCLC). Treatment options for patients with acquired EGFR-TKI resistance are limited. HER3 mediates EGFR-TKI resistance. Clinical trials of the HER3-targeting antibody–drug conjugate patritumab deruxtecan (HER3-DXd) demonstrated its anticancer activity in EGFR-mutated NSCLC; however, the mechanisms that regulate HER3 expression are unknown. This study was conducted with the aim to clarify the mechanisms underlying HER3 regulation in EGFR-mutated NSCLC tumors and explored the strategy for enhancing the anticancer activity of HER3-DXd in EGFR-mutated NSCLC.
Experimental Design:
Paired tumor samples were obtained from 48 patients with EGFR-mutated NSCLC treated with EGFR-TKI(s). HER3 expression was immunohistochemically quantified with H-score, and genomic alteration and transcriptomic signature were tested in tumors from pretreatment to post-EGFR-TKI resistance acquisition. The anticancer efficacy of HER3-DXd and osimertinib was evaluated in EGFR-mutated NSCLC cells.
Results:
We showed augmented HER3 expression in EGFR-mutated tumors with acquired EGFR-TKI resistance compared with paired pretreatment samples. RNA sequencing revealed that repressed PI3K/AKT/mTOR signaling was associated with HER3 augmentation, especially in tumors from patients who received continuous EGFR-TKI therapy. An in vitro study also showed that EGFR-TKI increased HER3 expression, repressed AKT phosphorylation in multiple EGFR-mutated cancers, and enhanced the anticancer activity of HER3-DXd.
Conclusions:
Our findings help clarify the mechanisms of HER3 regulation in EGFR-mutated NSCLC tumors and highlight a rationale for combination therapy with HER3-DXd and EGFR-TKI in EGFR-mutated NSCLC.
TABLE 2 from Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens
Authors: Tabernero Josep , Bedard Philippe L. , Bang Yung-Jue , Vieito Maria , Ryu Min-Hee , Fagniez Nathalie , Chadjaa Mustapha , Soufflet Christine , Masson Nina , Gazzah Anas
Published: August 2023

Treatment-emergent adverse events in cohorts Q2W-LD and Q3W (all-treated/safety population)
TABLE 1 from Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens
Authors: Tabernero Josep , Bedard Philippe L. , Bang Yung-Jue , Vieito Maria , Ryu Min-Hee , Fagniez Nathalie , Chadjaa Mustapha , Soufflet Christine , Masson Nina , Gazzah Anas
Published: August 2023

Baseline demographics and disease characteristics by DL in cohorts Q2W-LD and Q3W (all-treated/safety population)
Supplemental Table S5 from Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens
Authors: Tabernero Josep , Bedard Philippe L. , Bang Yung-Jue , Vieito Maria , Ryu Min-Hee , Fagniez Nathalie , Chadjaa Mustapha , Soufflet Christine , Masson Nina , Gazzah Anas
Published: August 2023

Plasma pharmacokinetics of tusamitamab ravtansine (cohort Q3W)
Supplementary Table 3 from Gemcitabine, Docetaxel, Capecitabine, Cisplatin, Irinotecan as First-line Treatment for Metastatic Pancreatic Cancer
Authors: Wilbur H. Catherine , Durham Jennifer N. , Lim Su Jin , Purtell Katrina , Bever Katherine M. , Laheru Daniel A. , De Jesus-Acosta Ana , Azad Nilofer S. , Wilt Bradley , Diaz Luis A. , Le Dung T. , Wang Hao
Published: August 2023

Supplementary Table 3: Patient Characteristics
Supplementary Figure 2 from Gemcitabine, Docetaxel, Capecitabine, Cisplatin, Irinotecan as First-line Treatment for Metastatic Pancreatic Cancer
Authors: Wilbur H. Catherine , Durham Jennifer N. , Lim Su Jin , Purtell Katrina , Bever Katherine M. , Laheru Daniel A. , De Jesus-Acosta Ana , Azad Nilofer S. , Wilt Bradley , Diaz Luis A. , Le Dung T. , Wang Hao
Published: August 2023

Supplementary Figure 2: OS and PFS
Supplemental Figure S1 from Tusamitamab Ravtansine in Patients with Advanced Solid Tumors: Phase I Study of Safety, Pharmacokinetics, and Antitumor Activity Using Alternative Dosing Regimens
Authors: Tabernero Josep , Bedard Philippe L. , Bang Yung-Jue , Vieito Maria , Ryu Min-Hee , Fagniez Nathalie , Chadjaa Mustapha , Soufflet Christine , Masson Nina , Gazzah Anas
Published: August 2023

Tusamitamab ravtansine maximum plasma concentrations by dose level
Data from Gemcitabine, Docetaxel, Capecitabine, Cisplatin, Irinotecan as First-line Treatment for Metastatic Pancreatic Cancer
Authors: Wilbur H. Catherine , Durham Jennifer N. , Lim Su Jin , Purtell Katrina , Bever Katherine M. , Laheru Daniel A. , De Jesus-Acosta Ana , Azad Nilofer S. , Wilt Bradley , Diaz Luis A. , Le Dung T. , Wang Hao
Published: August 2023

Purpose:
Treatment of advanced pancreatic cancer with a single therapeutic at a maximal dose has been largely ineffective at increasing survival. Combination therapies are commonly studied but often limited by toxicity. We previously showed that low-dose multiagent therapy with gemcitabine, docetaxel (taxotere), capecitabine (xeloda), and cisplatin (GTX-C) was safe, well tolerated, and effective (NCT01459614). Here, we hypothesize that adding irinotecan to GTX-C may improve survival with minimal toxicity.
Experimental Design:
Patients with treatment-naïve metastatic pancreatic adenocarcinoma were treated with gemcitabine, docetaxel (taxotere), capecitabine (xeloda), cisplatin, and irinotecan (GTX-CI). Treatment consisted of capecitabine 500 mg twice daily on days 1–14 and gemcitabine 300 to 500 mg/m2, docetaxel 20 mg/m2, cisplatin 15 to 20 mg/m2, and irinotecan 20 to 60 mg/m2 on days 4 and 11 of a 21-day cycle. The primary objective was 9-month overall survival (OS). Secondary objectives included response rate (RR), disease control rate (DCR), progression-free survival (PFS), and OS.
Results:
The regimen was well tolerated. The recommended phase II dose was gemcitabine 500 mg/m2, docetaxel 20 mg/m2, capecitabine 500 mg po bid, cisplatin 20 mg/m2, and irinotecan 20 mg/m2. Median follow-up in phase II was 11.02 months (2.37–45.17). Nine-month OS rate was 57% [95% confidence interval (CI): (41–77)]. RR was 57% [95% CI: (37–75) 50% PR and 7% CR]. DCR was 87% [95% CI: (69–96)]. Median OS and PFS were 11.02 [95% CI: (8.54–21.09)] and 8.34 [95% CI: (6.34–NA)] months, respectively.
Conclusions:
The addition of irinotecan to GTX-C was safe and well tolerated. While the study did not meet its primary objective, the responses were clinically meaningful using a well-tolerated regimen.
Significance:
We aimed to optimize the previously reported efficacious regimen of low-dose multiagent therapy with GTX-C for the treatment of metastatic pancreatic ductal adenocarcinoma by adding irinotecan. The primary objective was not met, but GTX-CI was well tolerated. The RR of 57%, median PFS of 8.3 months, median OS of 11 months, and 36-month OS rate of 19% suggest clinical benefit. Further optimization of this regimen is warranted.
Edoxaban for 12 Months Versus 3 Months in Patients With Cancer With Isolated Distal Deep Vein Thrombosis (ONCO DVT Study): An Open-Label, Multicenter, Randomized Clinical Trial
Authors: Yamashita Yugo , Morimoto Takeshi , Muraoka Nao , Oyakawa Takuya , Umetsu Michihisa , Akamatsu Daijirou , Nishimoto Yuji , Sato Yukihito , Takada Takuma , Jujo Kentaro , Minami Yuichiro , Ogihara Yoshito , Dohi Kaoru , Fujita Masashi , Nishikawa Tatsuya , Ikeda Nobutaka , Hashimoto Go , Otsui Kazunori , Mori Kenta , Sueta Daisuke , Tsubata Yukari , Shoji Masaaki , Shikama Ayumi , Hosoi Yutaka , Tanabe Yasuhiro , Chatani Ryuki , Tsukahara Kengo , Nakanishi Naohiko , Kim Kitae , Ikeda Satoshi , Mo Makoto , Yoshikawa Yusuke , Kimura Takeshi ,   on behalf of the ONCO DVT Study Investigators
Published: August 2023

BACKGROUND:

The optimal duration of anticoagulation therapy for isolated distal deep vein thrombosis in patients with cancer is clinically relevant, but the evidence is lacking. The prolonged anticoagulation therapy could have a potential benefit for prevention of thrombotic events; however, it could also increase the risk of bleeding.

METHODS:

In a multicenter, open-label, adjudicator-blinded, randomized clinical trial at 60 institutions in Japan, we randomly assigned patients with cancer with isolated distal deep vein thrombosis, in a 1-to-1 ratio, to receive either a 12-month or 3-month edoxaban treatment. The primary end point was a composite of a symptomatic recurrent venous thromboembolism (VTE) or VTE-related death at 12 months. The major secondary end point was major bleeding at 12 months, according to the criteria of the International Society on Thrombosis and Haemostasis. The primary hypothesis was that a 12-month edoxaban treatment was superior to a 3-month edoxaban treatment with respect to the primary end point.

RESULTS:

From April 2019 through June 2022, 604 patients were randomized, and after excluding 3 patients who withdrew consent, 601 patients were included in the intention-to-treat population: 296 patients in the 12-month edoxaban group and 305 patients in the 3-month edoxaban group. The mean age was 70.8 years, 28% of the patients were men, and 20% of the patients had symptoms of deep vein thrombosis at baseline. The primary end point of a symptomatic recurrent VTE event or VTE-related death occurred in 3 of the 296 patients (1.0%) in the 12-month edoxaban group and in 22 of the 305 patients (7.2%) in the 3-month edoxaban group (odds ratio, 0.13; 95% CI, 0.03–0.44). The major secondary end point of major bleeding occurred in 28 of the 296 patients (9.5%) in the 12-month edoxaban group and in 22 of the 305 patients (7.2%) in the 3-month edoxaban group (odds ratio, 1.34; 95% CI, 0.75–2.41). The prespecified subgroups did not affect the estimates on the primary end point.

CONCLUSIONS:

In patients with cancer with isolated distal deep vein thrombosis, 12 months was superior to 3 months for an edoxaban treatment with respect to the composite outcome of a symptomatic recurrent VTE or VTE-related death.

REGISTRATION:

URL:
https://www.clinicaltrials.gov
; Unique identifier: NCT03895502.
Updating manuscript types and formats for Palaeoentomology
Authors: SZWEDO JACEK , CAI CHEN-YANG , HUANG DI-YING , EVENHUIS NEAL L. , AZAR DANY
Published: August 2023

Prompted by a rapid development in the field of palaeoentomology, fossil terrestrial arthropods and amber research, Palaeoentomology was established in late 2018 through a collaborative effort between the International Palaeoentomological Society (IPS) and Magnolia Press (Azar et al., 2018). The inception of this scientific journal was met with enthusiastic reception from the palaeoentomological and amber community, and it achieved a consistent and robust growth throughout its initial five-year period (2018–2022). A significant milestone was attained in November 2022, as Palaeoentomology was granted acceptance into the Emerging Sources Citation Index™ (ESCI) within the esteemed Web of Science Core Collection™, a recognition indicative of its emerging influence. All papers published between 2018 and 2022 within Palaeoentomology were incorporated into the ESCI in January 2023, solidifying the journal’s presence and visibility within the scholarly landscape. More recently, according to June 2023 release of Journal Citation Reports, the 2022 journal impact factor of Palaeoentomology is 2.3, which is slightly higher than 2.2 estimated by Zhang (2023). Boasting a substantial impact factor, Palaeoentomology secures an impressive 20th position among 108 peers in the field of PALEONTOLOGY (Q1) and 8th position out of 57 in ENTOMOLOGY (Q1), further accentuating its influential stature (Clarivate Analytics, 2023). In order to continue fostering the rapid advancement of the journal, we are now implementing updates to the manuscript format of new submissions. A brief description of each article type is provided below.
Paleo-air pressures and respiration of giant Odonatoptera from the Late Carboniferous to the Early Cretaceous
Authors: CANNELL ALAN , NEL ANDRÉ
Published: August 2023

Adult Odonatoptera are among the most efficient flying predators. They have retained many physical characteristics over an immense period stretching from the Carboniferous to the present. Over this time they have greatly varied in size and mass, as shown in the fossil record and in particular by the length, shape, and structure of their wings. A fossil of Meganeurites gracilipes indicates that this large ‘griffenfly’ had a ‘hawker’ hunting behavior similar to certain extant species, with long periods of flight in which power, thermoregulation, and respiration would therefore tend to a ‘steady state’ equilibrium, allowing oxygen requirements and tracheole volumes to be projected and compared to extant ‘hawkers’. Comparing these values with standard pO2 models allows paleo-atmospheric density estimates to be derived. The results suggest that paleo-air pressure has varied from over two bars in the Late Carboniferous, Late Permian, and Middle to Late Jurassic, with lower values in the Early Triassic and Early Jurassic.
The strange holometabolan beak larva from about 100 million years old Kachin amber was physogastric and possibly wood-associated
Authors: HAUG CAROLIN , TUN KAY LWIN , LAY MON TIN , HNIN WAI WAI , HAUG JOACHIM T.
Published: August 2023

The group Neuropteriformia (beetles, lacewings, etc.) is today very species-rich, but also has a good fossil record in the Mesozoic. Amber provides not only adults, but also fossil larvae; some of these fossil neuropteriformian larvae have very unusual morphologies not seen in the modern fauna. We here report an unusual new fossil neuropteriformian larva. The mouthparts form a beak. Fossil larvae with similar mouthparts are known, and it seems that this new larva is a representative of the species ?Partisaniferus edjarzembowskii. The new larva, unlike the already known ones, has a large and inflated trunk. Based on comparison with extant larvae, such an inflated trunk should be considered physogastric. The new larva is only the second case of physogastry in fossil holometabolan larvae. Also early larvae of this species are known. The strong difference between the different larval stages give reason to interpret the ontogeny hypermetamorphic. Also this phenomenon is in fact very rare in the fossil record; most earlier candidates remain assumptions without further substantiation. Physogastry in larvae is often coupled to a mode of live in confined spaces, for a fossil preserved in amber this may mean living inside wood. Feeding mode might have been predatory, but could also have been feeding on fungi.
Taxonomy and nomenclature of Kalanchoe tomentosa (Crassulaceae subfam. Kalanchooideae), a variable, completely hairy species from Madagascar
Authors: SMITH GIDEON F.
Published: August 2023

The taxonomy and nomenclature of the Malagasy Kalanchoe tomentosa are reviewed and discussed in a historical context. An amplified description and illustrations are provided for the species and the name K. tomentosa is epitypified.
New species and new records of the genus Harpactea (Araneae, Dysderidae) from the Djurdjura National Park, Algeria
Authors: CHAIB SALMA , KHERBOUCHE-ABROUS OURIDA , BELADJAL LYNDA
Published: August 2023

Harpactea hamidae n.sp. is describe based on males from Tikjda region in the National Park of Djurdjura (Bouira, Algeria). It belongs to the species group and subgroup corticalis. Its distribution is summarized and discussed. New records for two other Harpactea species (H. heizerensis Bosmans & Beladjal, 1991 and H. innupta Beladjal & Bosmans, 1997) are presented.
A Single-Center Retrospective Study of Pediatric Vitiligo in a Tertiary Hospital
Authors: Martin Laura Beth , García Diaz Francisco José , Bernabeu Wittel José , Coronel Rodríguez Cristóbal
Published: August 2023

Vitiligo is a common disorder; however, its management is unknown by many primary-care doctors and pediatricians. Most articles focus on adults; we analyze the characteristics and impact on children. A single-center retrospective study was conducted over 10 years on 254 children diagnosed with vitiligo. About 50.4% were male with a mean age of 8.24 years. There was a slight predominance of nonsegmented vitiligo. About 12.59% had family history of vitiligo and 11.4% of autoimmune diseases. Around 15.7% patients presented other dermatological diseases and 9.05%, autoimmune diseases. No significant statistical differences were found when comparing age, sex, and type of vitiligo with other variables. Almost 96.06% received treatment with calcineurin inhibitors and 66.53% topical steroids. Around 77% obtained repigmentation, and out of the initial nonresponders, 16% responded to phototherapy. In general, our results concur with the scarce literature. A long-term follow-up of children with vitiligo is needed to identify treatment side effects and diseases associated.
Responding to Sexual Assault: A Systematic Review of Police Training Interventions and Outcomes
Authors: McQueen Karen , Murphy-Oikonen Jodie
Published: August 2023

Sexual assault is a worldwide issue that impacts many individuals, often with serious and long-lasting effects. Police play an important role for victims seeking justice. However, police response has been highly criticized as less than optimal. One question that remains unclear is whether sexual assault training improves police response. This quantitative review examined the effect of police training on diverse police outcomes. Five databases were systematically searched, which resulted in 10 published papers reporting on 12 studies. Our review found consistent evidence that suggests that sexual assault police training can improve various police attitudes, knowledge, and behaviors. However, further research is needed before specific recommendations regarding training can be made.
Psychiatric colonialism, PTSD and the Western psychiatric diagnostic tradition . . . is one man’s food another man’s poison?
Authors: Deahl Martin , Andreassen Michael
Published: August 2023

Sadly, much of the world is no stranger to Psychological Trauma, particularly in poorer areas with poor health infrastructure. Western Aid Organisations frequently deploy to such areas bringing with them a western psychiatric tradition of nosology and therapy which may not be appropriate in other cultures. We argue that imposing a western system of diagnosis and treatment may not only undermine local culture but may also be bad for the patient. We discuss this with reference to the WHO’s Mental Health Gap initiative (MHGap).
Microaggression toward LGBTIQ people and implications for mental health: A systematic review
Authors: Marchi Mattia , Travascio Antonio , Uberti Daniele , De Micheli Edoardo , Quartaroli Fabio , Laquatra Giuseppe , Grenzi Pietro , Pingani Luca , Ferrari Silvia , Fiorillo Andrea , Converti Manlio , Pinna Federica , Amaddeo Francesco , Ventriglio Antonio , Mirandola Massimo , Galeazzi Gian M
Published: August 2023

Background:

Research suggests that microaggressions detrimentally impact the mental health of members of marginalized social groups.

Aims:

The aim of this systematic review was to assess the exposure to microaggressions and related implications on mental health of Lesbian, Gay, Bisexual, Transgender, Intersex, and Queer (LGBTIQ) people.

Method:

Medline, Scopus, PsycINFO, CINAHL, and EMBASE were searched until January 2023. Studies reporting data on the exposure to microaggressions toward LGBTIQ people were identified. Meta-analyses of rates of exposure to microaggression and of the association between microaggressions and mental health outcomes were based on odds ratio (OR) and standardized mean difference (SMD) with 95% confidence intervals (95% CI), estimated through inverse variance models with random effects.

Results:

The review process led to the selection of 17 studies, involving a total of 9036 LGBTIQ people, of which 6827 identifying as cisgenders, and 492 as heterosexuals, were included in the quantitative synthesis. Overall, LGBTIQ people showed an increased risk of microaggression (SMD: 0.89; 95% CI [0.28, 1.50]), with Transgender people having the highest risk ( OR: 10.0; 95% CI [3.08, 32.4]). Microaggression resulted associated with risk of depression (SMD: 0.21; 95% CI [0.05, 0.37]), anxiety (SMD: 0.29; 95% CI [0.17, 0.40]), suicide attempts ( OR: 1.13; 95% CI [1.08, 1.18]), alcohol abuse ( OR: 1.32; 95% CI [1.13, 1.54]), but not to suicidal ideation ( OR: 1.56; 95% CI [0.64, 3.81]) and cannabis abuse ( OR: 1.44; 95% CI [0.82, 2.55]). The quality of the evidence was limited by the small number of studies.

Conclusions:

LGBTIQ people are at higher risk of microaggressions compared with their cisgender/heterosexual peers, which may lead to mental health consequences. This evidence may contribute to public awareness of LGBTIQ mental health needs and suggest supportive strategies as well as preventive interventions (e.g., supportive programs and destigmatizing efforts) as parts of tailored health-care planning aimed to reduce psychiatric morbidity in this population.
Bookshelf: Kappan authors on their favorite reads
Authors: Pendola Andrew
Published: August 2023

Kappan authors recommend favorite books that have inspired them. In this issue, Andrew Pendola recommends The Schooled Society by David Baker. Latrice Marianno recommends Teaching to Transgress by bell hooks.
Emerging stronger
Authors: Conway Brent
Published: August 2023

Pentucket Regional School District serves three small suburban communities north of Boston. Historically, its student performance had been quite high, but had been declining steadily for about a decade. The district had started reversing those losses, but the pandemic set it back. Now, however, the district has emerged even stronger; in most cases, student achievement already exceeds pre-pandemic levels. The reasons: new, high-quality curricula in multiple areas; a strong system of implementation supports; and a data-driven approach to help teachers address the specific needs of individual students. Assistant Superintendent Brent Conway explains how they did it.
Under The Law: Affirmative retraction
Authors: Kim Robert
Published: August 2023

Robert Kim and Kevin Welner discuss Students for Fair Admissions, Inc. v. Harvard College, in which the U.S. Supreme Court decreed that the admissions systems at the University of North Carolina (UNC) and Harvard College were unconstitutional. This ruling effectively banned the use of race-based admissions policies (i.e., affirmative action) in higher education. Kim and Welner explore what the ruling might mean for colleges and universities and the students seeking admission to them, implications for preK-12 education, and the larger context of social inequity.
Backtalk: ChatGPT: A powerful technology tool for writing instruction
Authors: Beck Sarah W. , Levine Sarah R.
Published: August 2023

Responding to widespread concern about the potential for artificial intelligence tool ChatGPT to enable cheating and discourage students from developing writing skills, authors Sarah W. Beck and Sarah R. Levine discuss how this latest and most powerful digital writing tool can help, rather than harm, developing writers. Drawing on research about the writing process and effective writing instruction, they outline ways that teachers can teach students to assess ChatGPT’s output with a critical eye and use the tool to overcome writers’ block and other obstacles to writing.
Essential but Ignored: Including Blue-Collar Government Workers Into Human Resource Management Research
Authors: Kruyen Peter M. , Sowa Jessica E.
Published: August 2023

Routine, manual, or blue-collar workers play a substantial role in delivering public services, especially at the local level. Despite their prevalence, scholars know little about the specifics of managing these human resources. This contribution challenges common stereotypes about blue-collar workers and argue a truly inclusive knowledge base on public- sector human resource management (HRM) must include these workers. Building upon the job characteristics model and the Ability–Motivation–Opportunity (AMO) model of HRM that links ability-, motivation-, and opportunity- HRM practices to job performance, a research agenda is put forward aiming to better understand blue-collar workers in government. Researchers are challenged to study blue-collar workers in government to truly construct both inclusive workplaces and an inclusive knowledge base in public personnel or public HRM research.
Thrombin Time is a Diagnostic Biomarker of Sudden Sensorineural Hearing Loss and Predicts the Prognosis
Authors: Chen Junying , Yang Yunhua , Huang Shuna , He Wenjuan , Lin Chang
Published: August 2023

Objectives:

The aim of this study is to determine whether thrombin time (TT) could be used as diagnostic biomarkers and predict the prognosis for sudden sensorineural hearing loss (SSNHL).

Methods:

Sixty-one patients diagnosed with SSNHL and 65 people who underwent physical examination were recruited. Data on the patient’s background, clinical course, and laboratory findings were collected. SSNHL patients were divided into the effective and ineffective groups according to the hearing recovery from the treatment and were assessed by binary logistic regression. Receiver-operating characteristic (ROC) analysis was carried out for the best discriminating cutoff value of the biomarker with the corresponding sensitivity and specificity was calculated.

Results:

The SSNHL group exhibited prolonged TT (19.11 ± 1.12 seconds) compared to the control group (17.58 ± 2.18 seconds, P < .001). Binary logistic regression analysis found a significant positive association between TT and SSNHL and was observed with an odds ratio (OR) 1.769 [95% confidence interval (CI) 1.344-2.330, P < .001] in the unadjusted model. Even after adjustment using the variables included in the multivariate models, TT was significantly predictive of SSNHL. A TT cutoff value of 17.65 seconds provides optimal separation between patients with SSNHL and controls in the ROC analysis [Area Under the Curve (AUC) 0.773, 95% CI 0.689-0.856; sensitivity, 0.918; and specificity, 0.569]. TT in the effective group of SSNHL patients was shorter (18.76 ± 1.06 seconds) than that in the ineffective group (19.43 ± 1.09 seconds, P = .018). The cutoff value of TT as progress predictors was 19.85 seconds. The TT < 19.85 seconds showed an effective rate 59.09% (26/44) higher than 17.65% (3/17) of TT ≥ 19.85 seconds.

Conclusions:

TT is a potential biomarker of SSNHL and is independently associated with the prognosis of patients with SSNHL.
Untimely Ecology: A Genealogy of Biosphere to Rethink Temporality in the Anthropocene
Authors: Maureira Marco
Published: August 2023

One of the critical challenges of our contemporary world is rethinking temporality to face the global catastrophe of the Anthropocene. Recent theories in social sciences and philosophy envision a new conceptualization of our biosphere in which human and non-human life forms, inert objects, and technological devices are entangled. However, these approaches present two major problems: a) they affirm that organic and inorganic processes are ontologically symmetrical and have the same type of agency; and b) they consider that technicity on planet Earth emerges in the hominization process. In this work, we will develop a genealogy of our biosphere that proposes an ecological and untimely alternative: life, from its earliest beginning, is a technical phenomenon that changes the face of the universe.
Influence of local features on twist springback of high-strength steel long channels
Authors: Li Maoyang , Wang Rui , Pang Qiu , Niu Chao , Liu Xiang , Hu Zhili
Published: August 2023

With the wide use of high-strength steel (HSS) in structural body parts, the twist springback of high-strength steel parts has received extensive attention. Unlike automotive panels, structural body parts are arranged with many local features to meet functional requirements. The aim of this study is to investigate the influence of local features on twist springback to optimize the design of local features to reduce twist springback. In this paper, a typical long channel part (A-pillar upper inner plate) is taken as the object of study. A suitable location division method for this type of part is proposed to investigate the changes in twist springback and cross-sectional stresses in the part before and after the addition of local features at different locations through finite element simulations. The results show that the local features affect the stiffness and stress distribution of the parts and significantly affect the twist springback of the parts. Finally, the research results guided the optimization of the local feature design of an A-pillar upper inner plate, resulting in a remarkable 37% and 61% decrease in twist springback at the left and right ends of the optimized part, respectively. In addition, stamping molds were developed for optimized parts, and experiments were carried out to verify the effectiveness of the law and the reliability of the finite element model.
The divide so wide: Public perspectives on the role of human genome editing in the US healthcare system
Authors: Nelson John P. , Tomblin David C. , Barbera Avery , Smallwood Melissa
Published: August 2023

We report findings from two open-framed focus groups eliciting informed public opinion about the rapidly developing technology of human genome editing in the context of the US healthcare system. Results reveal that participants take a dim view of the present healthcare system, articulating extensive concerns about the accessibility and affordability of care. They feel that, unless these problems are resolved, they stand little chance of benefiting from any eventual human genome editing treatments. They prioritize improvement in healthcare access well above human genome editing development, and human genome editing regulation and oversight above human genome editing research. These results reveal substantial divergence between public perspectives and expert discourse on human genome editing. The latter attends primarily to the moral permissibility of technical categories of human genome editing research and how to treat human genome editing within existing regulatory and oversight systems rather than broader political-economic and healthcare access concerns. This divergence illustrates the importance of openly framed public engagement around emerging technologies.
Intracranial embryonal neoplasm in an alpaca
Authors: Fielding Alexandra , Minuto Jillian , Mazan Melissa , Miller Andrew D. , Newman Shelley J.
Published: August 2023

An 11-y-old hembra alpaca was admitted because of cerebellar and vestibular signs, dysphagia, and aspiration pneumonia; without clinical improvement following empirical therapy, the patient was euthanized. On autopsy, a neoplasm was found incorporating the right vestibulocochlear nerve at the level of the acoustic meatus. Histologically, the mass was composed of a multiphasic primitive cell population associated with a dense fibrous stroma and enveloping a remnant ganglion and nerve bundles. Patterns included dense ribbons and cords of embryonal neuroepithelial cells admixed with loosely defined interlacing spindle cells. The embryonal cells had angular cell profiles with variable amounts of lightly basophilic cytoplasm, ovoid-to-irregular nuclei, and an open chromatin pattern with a typically inapparent nucleolus. Necrosis was not evident, and there was 1 mitotic figure per 2.37 mm2. The entire mass was infiltrated by small numbers of lymphocytes and plasma cells. Immunohistochemistry (IHC) revealed strong and diffuse cytoplasmic immunolabeling for vimentin, microtubule-associated protein-2, protein gene product 9.5, and synaptophysin; ~50% immunolabeling for cytokeratin AE1/3; sporadic OLIG2 and S100 immunolabeling; and absent glial fibrillary acidic protein immunolabeling. Based on the histologic pattern and the IHC results, our diagnosis was a poorly differentiated embryonal tumor with ependymal differentiation associated with the vestibulocochlear nerve.
Prosecuting Military Sexual Assault: The Entanglement of Military Discourse and Victim Stereotypes in Prosecutor Case Strategies
Authors: Bonnes Stephanie , Tosto Samantha A.
Published: August 2023

High rates of sexual assault within the United States Armed Forces have led to several initiatives designed to combat sexual violence and increase prosecution of perpetrators. While scholars argue that the military’s hypermasculine culture contributes to high rates of victimization, less is known about how this culture impacts each case within the military justice system. Using in-depth interviews, we explore how military prosecutors develop strategies to navigate this uniquely gendered terrain as it intersects with victim stereotypes. Findings suggest that prosecutors invoke military discourse to combat rape myths but are constrained by gendered assumptions of the ideal servicemember.
COVID-19 vaccine immune response in patients with plasma cell dyscrasia: a systematic review
Authors: Faizan Unaiza , Nair Lakshmi G. , Bou Zerdan Maroun , Jaberi-Douraki Majid , Anwer Faiz , Raza Shahzad
Published: August 2023

Background:

Patients with plasma cell dyscrasia are at a higher risk of developing a severe Coronavirus-2019 (COVID-19) infection. Here we present a systematic review of clinical studies focusing on the immune response to the COVID-19 vaccination in patients with plasma cell dyscrasia.

Objectives:

This study aims to evaluate the immune response to COVID-19 vaccines in patients with plasma cell dyscrasia and to utilize the results to improve day-to-day practice.

Design:

Systematic Review

Methods:

Online databases (PubMed, CINAHL, Ovid, and Cochrane) were searched following the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. Only articles published in the English language were included. Out of 59 studies, nine articles (seven prospective and two retrospective studies) were included in this systematic review. Abstracts, case reports, and case series were excluded.

Results:

In all nine studies ( N = 1429), seroconversion post-vaccination was the primary endpoint. Patients with plasma cell disorders had a lower seroconversion rate compared to healthy vaccinated individuals and the overall percentage of seroconversion ranged between 23% and 95.5%. Among patients on active therapy, lower seroconversion rates were seen on an anti-CD38 agent, ranging from 6.5 up to 100%. In addition, a significantly lower percentage was recorded in older patients, especially in those aged equal to or greater than 65 years and those who have been treated with multiple therapies previously. Only one study reported a statistically significant better humoral response rate with the mRNA vaccine compared to ADZ1222/Ad26.Cov.S.

Conclusion:

Variable seropositive rates are seen in patients with plasma cell dyscrasia. Lower rates are reported in patients on active therapy, anti-CD38 therapy, and elderly patients. Hence, we propose patients with plasma cell dyscrasias should receive periodic boosters to maintain clinically significant levels of antibodies against COVID-19.

Registration:

PROSPERO ID: CRD42023404989
Cohort profile: GRACE – a residential aged care cohort examining factors influencing antimicrobial resistance carriage
Authors: Carpenter Lucy , Shoubridge Andrew P. , Flynn Erin , Lang Catherine , Taylor Steven L. , Papanicolas Lito E. , Collins Josephine , Gordon David , Lynn David J. , Crotty Maria , Whitehead Craig , Leong Lex E. X. , Wesselingh Steve L. , Ivey Kerry , Inacio Maria C. , Rogers Geraint B.
Published: August 2023

Background

The emergence of antimicrobial-resistant bacteria represents a considerable threat to human health, particularly for vulnerable populations such as those living in residential aged care. However, antimicrobial resistance carriage and modes of transmission remain incompletely understood. The Generating evidence on antimicrobial Resistance in the Aged Care Environment (GRACE) study was established to determine principal risk factors of antimicrobial resistance carriage and transmission in residential aged care facilities (RACFs). This article describes the cohort characteristics, national representation, and planned analyses for this study.

Methods

Between March 2019 and March 2020, 279 participants were recruited from five South Australian RACFs. The median age was 88.6 years, the median period in residence was 681 days, and 71.7% were female. A dementia diagnosis was recorded in 54.5% and more than two thirds had moderate to severe cognitive impairment (68.8%). 61% had received at least one course of antibiotics in the 12 months prior to enrolment.

Results

To investigate the representation of the GRACE cohort to Australians in residential aged care, its characteristics were compared to a subset of the historical cohort of the Registry of Senior Australians (ROSA). This included 142,923 individuals who were permanent residents of RACFs on June 30th, 2017. GRACE and ROSA cohorts were similar in age, sex, and duration of residential care, prevalence of health conditions, and recorded dementia diagnoses. Differences were observed in care requirements and antibiotic exposure (both higher for GRACE participants). GRACE participants had fewer hospital visits compared to the ROSA cohort, and a smaller proportion were prescribed psycholeptic medications.

Conclusions

We have assembled a cohort of aged care residents that is representative of the Australian aged care population, and which provides a basis for future analyses. Metagenomic data isolated from participants and built environments will be used to determine microbiome and resistome characteristics of an individual and the facility. Individual and facility risk exposures will be aligned with metagenomic data to identify principal determinants for antimicrobial resistance carriage. Ultimately, this analysis will inform measures aimed at reducing the emergence and spread of antimicrobial resistant pathogens in this high-risk population.
Osteoarticular infection caused by Talaromyces Marneffei and Salmonella in a person living with HIV: a case report
Authors: Yu Lele , Zhang Binhai , Shi Jinchuan , Wang Mengyan , Wan Hu
Published: August 2023

Introduction

Talaromycosis is a common invasive fungal disease in patients with HIV. However, its association with bone destruction is unusual in AIDS patients with talaromycosis.

Case Presentation

This report covers the case of a 38-year-old male AIDS patient coinfected with Talaromyces marneffei and Salmonella. The case, which involved bone destruction, was identified via metagenomic next-generation sequencing (mNGS). Following treatment with a combination of amphotericin B and piperacillin-tazobactam, the patient’s elbow motion noticeably improved. Imaging findings revealed that the progression of bony destruction had halted.

Conclusion

Bone damage due to Talaromyces marneffei infection is infrequent in HIV-positive patients. Therefore, healthcare professionals must be vigilant for potential bone lesions associated with this type of infection. Prompt diagnosis and antimicrobial treatment are crucial.
Clinical perspectives and outcomes of the giant breast phyllodes tumor and sarcoma: a real-world retrospective study
Authors: Liu Naiquan , Kang Ye , Qu Ningxin , Kong Chenhui , Han Ye
Published: August 2023

Background

Giant breast malignant phyllodes tumor or sarcoma (GBPS) are rare entities with diameter larger than 10 cm and variously histological pleomorphisms. This disease poses a significant threat to the quality of life of individuals, and its prognosis remains unclear. This study aimed to explore the differential diagnosis, treatment, and prognosis of GBPS in a real-world retrospective cohort.

Methods

We collected GBPS (diameter > 10 cm, n = 10) and BPS (diameter ≤ 10 cm, n = 126) from patients diagnosed with sarcoma or malignant phyllodes tumor between 2008 and 2022. We analyzed clinical characteristics, histological status, treatment, and local recurrence using the Fisher’s exact test between GBPS (diameter > 10 cm) and BPS (diameter ≤ 10 cm) cohort. We described overall survival (OS) and disease-free survival (DFS) using Kaplan–Meier curves and identified risk factors for local recurrence using logistic regression. The tumor size, age at diagnosis, and differential immunohistochemistry markers of breast sarcoma or phyllodes tumor to determine the prognosis of GBPS.

Results

In our retrospective analysis of breast malignancies, we identified 10 cases of GBPS and 126 cases of BPS, corresponding to a GBPS prevalence of 0.17% (10/6000). The median age was 38.5 years (inter-quartile range, IQR: 28.25–48.5 years). During the follow-up of period (median: 80.5 months, IQR: 36.75–122 months), the local recurrence (LR) rate was 40% and 20.6%, respectively. Clinical characteristics of young age (HR:2.799, 95%CI -00.09276—0.017, p < 0.05) and cytological characteristics of marked stromal atypia (HR:0.88, 95% CI 0.39–1.40, p < 0.05) were risk factors for the poor prognosis of GBPS by COX regression model analysis. The Kaplan–Meier curves of GBPS 5-year disease-free survival (DFS) and overall survival (OS) were 31.5 months and 40 months, respectively, and were not associated with adjuvant radiation or chemotherapy.

Conclusion

We recommend mastectomy with a clear surgical margin as the preferred treatment for GBPS. Age and stromal atypia are significantly associated with recurrence. Adjuvant radiation therapy is advised; however, there was no improvement in overall survival. There is no consensus on the effectiveness of adjuvant chemotherapy and genetic methods, highlighting the need for further research into this aggressive tumor. We recommend a multidisciplinary approach involving a dedicated team for the management of GBPS.
The antitumor effect of oncolytic respiratory syncytial virus via the tumor necrosis factor-alpha induction and ROS-bax-mediated mechanisms
Authors: Samadi Mehdi , Mokhtari-Azad Talat , Nejati Ahmad , Norooz-Babaei Zahra , Foroushani Abbas Rahimi , Haghshenas Mohammad Reza , Adjaminejad Fatemeh , Zargaran Hedieh , Salimi Vahid , Ghaemi Amir
Published: August 2023

Background

Cervical cancer represents one of the most prevalent cancers among women worldwide, particularly in low- and middle-income nations. Oncolytic viruses (OVs) can infect cancer cells selectively and lethally without harming normal cells. Respiratory syncytial virus (RSV) is an oncolytic virus for anticancer therapy because of its propensity to multiply within tumor cells. This research aimed to assess the in vitro antitumor activities and molecular basis processes of the oncolytic RSV-A2 on the TC-1 cancer cells as a model for HPV‑related cervical cancers.

Methods

Cellular proliferation (MTT) and lactate dehydrogenase (LDH) release assays were used to investigate the catalytic impacts of RSV-A2 by the ELISA method. Real-time PCR and flow cytometry assays were utilized to assess apoptosis, autophagy, intracellular concentrations of reactive oxygen species (ROS), and cell cycle inhibition.

Results

Our MTT and LDH results demonstrated that TC-1 cell viability after oncolytic RSV-A2 treatment was MOI-dependently and altered significantly with increasing RSV-A2 virus multiplicity of infection (MOI). Other findings showed that the RSV-A2 potentially resulted in apoptosis and autophagy induction, caspase-3 activation, ROS generation, and cell cycle inhibition in the TC-1 cell line. Real-time PCR assay revealed that RSV-A2 infection significantly elevated the Bax and decreased the Bcl2 expression.

Conclusions

The results indicated that oncolytic RSV-A2 has cytotoxic and inhibiting effects on HPV-associated cervical cancer cells. Our findings revealed that RSV-A2 is a promising treatment candidate for cervical cancer.