bluuebunny/crossref_metadata_2025 huggingface dataset:
Strong perturbation of a super-virial Magellanic circum-galactic medium
Authors: Locatelli Nicola , Ponti Gabriele , Merloni Andrea , Zheng Xueying , Dennerl Konrad , Haberl Frank , Maitra Chandreyee , Sanders Jeremy , Sasaki Manami , Vazza Franco
Published: February 2023

Modern galaxy evolution theories predict a large fraction of ordinary matter to be distributed in the form of gas over the largest galactic scales, with most of the gas mass encompassing the peak and high tail of the overall temperature distribution1. Satellite galaxies however, may lose a large amount of this extended gas due to stripping and ram pressure generated by their in-fall onto a larger system2. The presence of highly ionized gas associated with the Small and Large Magellanic Clouds has been recently confirmed through indirect probes3,4. Using eROSITA/SRG data, in this work we show the first direct images of the X-ray emission from the hottest gas associated to the circum-galactic medium surrounding the Magellanic Clouds. We discover an extended hot gas phase at ~2.3×106 K. This temperature challenges the theoretical expectations from a virialized system5,6 implying that heating mechanisms are at play in the Magellanic Clouds circum-galactic medium. We also discover a strong perturbation that we identify as a cold front in the (Galactic) South direction of the Magellanic Clouds, morphologically connected to them both. The cold front -the first ever discovered at galactic scales (~10 kpc)- also appears to be coincident with enhanced polarization at radio frequencies, as well as with a tangential alignment of the magnetic field lines. The detected discontinuity in the properties of the gas surrounding the Magellanic Clouds is consistent with a gas reservoir being perturbed by the three-body interaction between the Magellanic Clouds and the Milky Way7,8. The Magellanic Clouds provide a unique laboratory for assessing the presence of a hot gas phase in in-falling satellite systems9. The detection of a still large reservoir of hot gas, together with the detection of a front connected with thermal heating and magnetic amplification corroborates and inform galaxy evolution theories10.
Identification of 6 cuproptosis- and ferroptosis-related genes linking immune infiltration as diagnostic biomarkers for acute myocardial infarction
Authors: Zheng Mingqi , Miao Mengdan , Cao Shanhu , Tian Yifei , Liu Da , Chen Lixia , Chai Qingying , Wei Mei , Sun Shaoguang , Wang Le , Xin Shuanli , Liu Gang
Published: February 2023

The current diagnostic biomarkers of acute myocardial infarction (AMI), troponins, lack specificity and exist as false positives in other non-cardiac diseases. Previous studies revealed that cuproptosis, ferroptosis, and immune infiltration are all involved in the development of AMI. We hypothesize that combining the analysis of cuproptosis, ferroptosis, and immune infiltration in AMI will help identify more precise diagnostic biomarkers. The results showed that a total of 19 cuproptosis- and ferroptosis-related genes (CFRGs) were differentially expressed between the healthy and AMI groups. Functional enrichment analysis showed that the differential CFRGs were mostly enriched in biological processes related to oxidative stress and the inflammatory response. The immune infiltration status analyzed by ssGSEA found elevated levels of macrophages, neutrophils, and CCR in AMI. Then, we screened 6 immune-related CFRGs (CXCL2, DDIT3, DUSP1, CDKN1A, TLR4, STAT3) to construct a nomogram for predicting AMI and validated it in the GSE109048 dataset. Moreover, we also identified 5 pivotal miRNAs and 10 candidate drugs that target the 6 feature genes. Finally, RT-qPCR analysis verified that all 6 feature genes were upregulated in both animals and patients. In conclusion, our study reveals the significance of immune-related CFRGs in AMI and provides new insights for AMI diagnosis and treatment.
Analysis of the magnetoplasticity of steel by constructing the absorption spectrum of mechanical energy at magnetic resonance
Authors: Kraiev Maksym
Published: February 2023

The tensile test of steels St3 (GOST 380 − 94) and 40X (GOST 4543 − 2016) in an external constant magnetic field with an induction of 1,2 T was performed. Deformation energy absorption is a manifestation of the magnetoplastic effect. The similarity of the action of a magnetic field in tensile testing of samples and in the study of classical magnetic resonance is described. A new method for analyzing the magnetoplasticity of bulk samples by analogy with the construction of the energy absorption spectrum at magnetic resonance has been applied. The energy absorption spectrum is plotted in the coordinates of the metal flow stress – dislocation density. The characteristics of the spectrum line are determined: its depth as the value of the absolute decrease in the metal flow stress, as well as its width according to the FWHM (Full With at Half Maximum) value.
Living Alone or Together: Effect of Social Benefits
Authors: de Mahieu Antoine
Published: February 2023

In most European countries, poor cohabiting adults are eligible to lower per capita social assistance benefits than poor adults living alone, as they are supposed to benefit from economies of scale in household expenses as housing, heating costs, etc. In this paper, we show that this aspect of social assistance varies strongly within Europe and use this variation to identify a possible causality of social assistance scheme parameters on cohabitation decisions. Our statistical analysis, that focuses on childless adults, suggests that high benefits for cohabitants decrease the number of poor one-person households significantly. We then discuss how this result affects government expenses on social assistance and the related policy implications. Lastly, we estimate the marginal cost of marginally increasing the benefits for cohabitants in the different European countries, and show that it is close to zero for some countries with strongly differentiated rates and a low initial share of cohabitants among the socially assisted.
JEL: J12, J18
Fighting reviewer fatigue or amplifying bias? Considerations and recommendations for use of ChatGPT and other Large Language Models in scholarly peer review
Authors: Hosseini Mohammad , Horbach Serge P.J.M.
Published: February 2023

Background:
The emergence of systems based on large language models (LLMs) such as OpenAI’s ChatGPT has created a range of discussions in scholarly circles. Since LLMs generate grammatically correct and mostly relevant (yet sometimes outright wrong, irrelevant or biased) outputs in response to provided prompts, using them in various writing tasks including writing peer review reports could result in improved productivity. Given the significance of peer reviews in the existing scholarly publication landscape, exploring challenges and opportunities of using LLMs in peer review seems urgent. After the generation of the first scholarly outputs with LLMs, we anticipate that peer review reports too would be generated with the help of these systems. However, there are currently no guidelines on how these systems should be used in review tasks.
Methods:
To investigate the potential impact of using LLMs on the peer review process, we used five core themes within discussions about peer review suggested by Tennant and Ross-Hellauer. These include 1) reviewers’ role, 2) editors’ role, 3) functions and quality of peer reviews, 4) reproducibility, and 5) the social and epistemic functions of peer reviews. We provide a small-scale exploration of ChatGPT’s performance regarding identified issues.
Results:
LLMs have the potential to substantially alter the role of both peer reviewers and editors. Through supporting both actors in efficiently writing constructive reports or decision letters, LLMs can facilitate higher quality review and address issues of review shortage. However, the fundamental opacity of LLMs’ inner workings and development, raise questions and concerns about potential biases and the reliability of review reports. Additionally, as editorial work has a prominent function in defining and shaping epistemic communities, as well as negotiating normative frameworks within such communities, partly outsourcing this work to LLMs might have unforeseen consequences for social and epistemic relations within academia. Regarding performance, we identified major enhancements in only a few weeks (between December 2022 and January 2023) and expect ChatGPT to continue improving.
Conclusions:
We believe that LLMs are likely to have a profound impact on academia and scholarly communication. While they have the potential to address several current issues within the scholarly communication system, many uncertainties remain and their use is not without risks. In particular, concerns about the amplification of existing biases and inequalities in access to appropriate infrastructure warrant further attention. For the moment, we recommend that if LLMs are used to write scholarly reviews, reviewers should disclose their use and accept full responsibility for their reports’ accuracy, tone, reasoning and originality.
Implementation of evidence-based primary cancer prevention interventions in MA community health centers: an explanatory sequential mixed methods study
Authors: LEE REBEKKA M , Daly James G , Mallick Kamini , Ramanadhan Shoba , Torres Cristina Huebner , Hayes Cassidy R , Manuel Alyssa , Nalls Ra’Shaun , Emmons Karen M
Published: February 2023

Background
More than half of cancers could be prevented by employing evidence-based interventions (EBIs), including prevention interventions targeting nutrition, physical activity, and tobacco. Federally qualified health centers (FQHCs) are the primary source of patient care for over 30 million Americans – making them an optimal setting for ensuring evidence-based prevention that advances health equity. The aims of this study are to: 1) determine the degree to which primary cancer prevention EBIs are being implemented within Massachusetts FQHCs and 2) describe how these EBIs are implemented internally and via community partnerships.
Methods
We used an explanatory sequential mixed methods design to assess the implementation of cancer prevention EBIs. First, we used quantitative surveys of FQHC staff to determine the frequency of EBI implementation. We followed up with qualitative one-on-one interviews among a sample of staff to understand how the EBIs selected on the survey were implemented. Exploration of contextual influences on implementation and use of partnerships was guided by the Consolidated Framework for Implementation Research (CFIR). Quantitative data were summarized descriptively, and qualitative analyses used reflexive, thematic approaches, beginning deductively with codes from CFIR, then inductively coding additional categories.
Results
All FQHCs indicated they offered clinic-based tobacco interventions, such as clinician-delivered screening practices and prescription of tobacco cessation medications. Quitline interventions and some diet/physical activity EBIs were available at all FQHCs, but staff perceptions of penetration were low. Only 38% of FQHCs offered group tobacco cessation counseling and 63% referred patients to mobile phone-based cessation interventions. We found multilevel factors influenced implementation across intervention types – including the complexity of intervention trainings, available time and staffing, motivation of clinicians, funding, and external policies and incentives. While partnerships were described as valuable, only one FQHC reported using clinical-community linkages for primary cancer prevention EBIs.
Conclusions
Adoption of primary prevention EBIs in Massachusetts FQHCs is relatively high, but stable staffing and funding are required to successfully reach all eligible patients. FQHC staff are enthusiastic about the potential of community partnerships to foster improved implementation - providing training and support to build these relationships will be key to fulfilling that promise.
MRI analysis of gallbladder changes with gestational weeks between fetuses with type I congenital choledochal cyst and healthy fetuses
Authors: Gao Duo , Jia Linyi , Zheng Jianxiong , Li Yingchao , Zhang Chengxiang , Cao Yimin , Yi Zexi , Geng Zuojun , Zhou Lixia
Published: February 2023

Purpose
To retrospectively analyze the prenatal MRI image characteristics of fetuses with type I congenital choledochal cyst and healthy fetuses, and to clarify the changes of gallbladder with gestational weeks.
Methods
We retrospectively reviewed prenatal MRI features of healthy fetuses and fetuses with type I choledochal cysts confirmed by operation after birth from January 2018 to March 2022. Clinical data and image findings (the maximum transverse and longitudinal diameters of gallbladder, liver and spleen, the diameters of choledochal cysts at transverse, coronal and sagittal planes and the maximum diameters of portal vein) were recorded. The features in two groups were then analyzed.
Results
A total of 139 fetuses were included, 100 in the healthy fetuses and 39 in the type I choledochal cysts. We found a nonlinear relationship between gestational weeks and gallbladder size with two inflection points of 27 and 34 in fetuses with type I choledochal cyst, after adjusting for potential confounders. In normal fetuses, however, the relationship is linear.
Conclusions
The relationship between gestational weeks and gallbladder size is non-linear in fetuses with type I choledochal cyst, with gallbladder size shrinking and spleen enlargement compared to healthy fetuses.
Dielectric properties of (1‑x) PbMg1/3Nb2/3 O3 ‑ (x) AlBiO3 ceramic nanomaterials
Authors: Legesse Kebede , Elangovan Sampandam
Published: February 2023

Dielectric materials are electrical insulators that can be polarized by temperature, pressure, and applied electric field. Dielectric typically means materials with a high polarisability. In this study, temperature and frequency effects on lead magnesium niobate – Aluminium Bismuthate (1x) PbMg1/3Nb2/3 O3 (x) AlBiO3 solid solution ceramics with the compositions (x = 0.1, 0.2, and 0.3 were discussed. The ceramic composites were synthesized by the solid-state reaction method. The temperature and frequency-dependent dielectric properties were studied using the complex impedance spectroscopic method at various temperatures and applied frequencies. Real and imaginary parts of the dielectric constants were determined as a function of temperature and frequency. The dielectric constant of (1x) PbMg1/3Nb2/3 O3 (x) AlBiO3 ceramics, increased with increasing the temperature and AlBiO3 concentrations. The maximum value of dielectric constant (Tm) was obtained at 86oC with the frequency of 1kHz at the composition x = 0.3. The systematic analysis of dielectric property suggested that the (1x) PbMg1/3Nb2/3 O3 (x) AlBiO3 with x = 0.1, 0.2, and 0.3 ceramics are anticipated as one of the useful low lead electronic materials. Furthermore, the dielectric constant of the composites can be varied by their composition, temperature, and ac-biased field.
Soaking time effect on the structural and dielectric properties of microwave sintered cobalt ferrite nanomaterials
Authors: Goswami Abhinava , Pukhram Sonica , Soibam Ibetombi
Published: February 2023

Auto-combustion method was employed to synthesize cobalt ferrite nanopowders having structural formula CoFe2O4. Then the as-prepared sample was calcined at 600°C in a microwave furnace for 30 minutes at 5°C/min heating rate. The calcined sample was given microwave sintering at 700°C at the same heating rate for three different soaking time viz. 2 hours, 4 hours and 6 hours. Phase confirmation of the sintered samples was done using XRD data. The presence of metal oxide bonds in the samples was confirmed by FTIR spectra. From the XRD spectra, crystallite sizes, lattice constants, theoretical densities and porosities of the samples were found out. Dielectric properties such as dielectric constant, dielectric loss, impedance and ac conductivity of all the samples were studied using Agilent LCR meter in the frequency ranging from 20 Hz to 2 MHz. Variation of dielectric constant and dielectric loss with frequency showed normal dispersive behaviour of ferrites which can be explained using the Maxwell-Wagner model. With increasing soaking time, the dielectric loss increased but the opposite trend was observed for the dielectric constant at the higher frequency region. As the frequency increased, the ac conductivity of the samples increased owing to enhanced hopping of electrons between cations. Impedance values of the samples were found to decrease slightly in the low-frequency region and swift decrease in the high-frequency region. Soaking time effects on the ac conductivity were also reported.
Use of Qualitative Tools for Evaluating the Implementation of Green Design in Industries
Authors: Casqueiro Renata Alves , de Almeida Giovana Giarola , Poltronieri Camila Fabrício , Hoelzel Carlos Gustavo Martins , Severino Maico Roris
Published: February 2023

The emergence of major environmental impacts caused by industrial activities can be observed, which generates great pressure for the adoption of more sustainable practices in companies. One of the alternatives for this is the Green Supply Chain Management (GSCM), composed of various practices, one of them being Green Design (GD). Analyzing the current state of the literature on this topic, it is observed that the studies, for the most part, approach the creation of implementation or evaluation indicators for GD and few deal with them in a combined and easily applicable way. Thus, a gap is perceived with regard to proving the possibility of incorporating sustainable aspects into industrial products and processes through the application of GD using non-complex qualitative tools. Therefore, the overall objective of this research is to analyze the feasibility of applying GD in industries using this type of tool. To this end, a literature review on GD was carried out, from which a qualitative tool focused on its implementation and evaluation was identified. Then a case study was developed in an industry, and, for each indicator of the chosen tool, a general analysis of the content was carried out and then suggestions for improvements in the processes and product analyzed were presented. With this, it was possible to highlight that the applied tool allows sustainable practices related to GD to be implemented and evaluated in industrial scenarios of any branch, due to the generic character of the indicators.
Lightweight integration of a data cache for opportunistic usage of HPC resources in HEP workflows
Authors: Sammel Dirk , Boehler Michael , Gamel Anton Josef , Schumacher Markus
Published: February 2023

A data caching setup has been implemented for the High Energy Physics (HEP) computing infrastructure in Freiburg, Germany, as a possible alternative to local long-term storage. Files are automatically cached on disk upon first request by a client, can be accessed from cache for subsequent requests, and are deleted after predefined conditions are met. The required components are provided to a dedicated HEP cluster, and, via virtual research environments, to the opportunistically used High-Performance Computing (HPC) Cluster NEMO (Neuroscience, Elementary Particle Physics, Microsystems Engineering and Materials Science). A typical HEP workflow has been implemented as benchmark test to identify any overhead introduced by the caching setup with respect to direct, non-cached data access, and to compare the performance of cached and non-cached access to several external files sources. The results indicate no significant overhead in the workflow and faster file access with the caching setup, especially for geographically distant file sources. Additionally, the hardware requirements for various numbers of parallel file requests were measured for estimating future requirements.
Identification of Cuproptosis-related key genes in seminoma using machine learning and Weighted Gene Co-expression Networks analyses
Authors: Cui Yankang , Fang Bo , Zhang Jing , Bu Hengtao , Shen Tianyi , Wang Suchun , Yi Xiaoming , Shi Changjie , Tang Hao , He Haowei , Ge Jingping , Xu Feng , Shang Xuejun
Published: February 2023

Background: Cuproptosis is a novel form of programmed cell death which induced by copper. The special histology markers for diagnosing seminoma have not gained development in recent years.
Results: A total of 165 normal testes and 78 seminoma samples were included in this study. After WGCNA analyses, 185 genes were intersected in seminoma and cluster characteristics module gene sets. The hub-genes of the 4 machine learning methods (FAM149B1, ARL6IP4, and RNASEH2B) displayed the highest area under curve (AUC=1). The expression of the 3 hub-genes were all down-regulated in seminoma. The nomogram based on the 3 hub-genes displayed satisfactory performance on diagnosing seminoma, according to calibration curve and decision curve analysis. Additionally, the results of the ROC analyses, using staining intensity, indicated that the combination of the 3 hub-genes showed the highest specificity and sensitivity (AUC=0.964, 95%Cl=0.895-1.000) for diagnosing seminoma.
Conclusion: This is the first study using interactive and comprehensive bioinformatic methods to investigate the special markers for diagnosing seminoma from the perspective of Cuproptosis. The 3 hub-genes (FAM149B1, ARL6IP4, and RNASEH2B) were all down-regulated in seminoma. The three-gene model for the cytological diagnosis of indeterminate seminoma is both feasible and promising. Implementation of this as an adjunct to testis cytology may significantly impact the clinical management of patients with suspicious or indeterminate testicular lesions.
Effects of Massage on Neuro-Vascular Regulation and Apoptosis in Rabbits with Cervical Spondylosis of the Vertebral Artery Type
Authors: Wang Chao , Xu Hui , Xiong Yingzong , Su Yi , Li Yingchun , Zhu Junchen
Published: February 2023

Objective To explore the therapeutic mechanisms of massage for cervical spondylosis of vertebral artery type (CSA) from the effects of sympathetic neurotransmitter changes on vertebral artery blood flow and apoptosis. Methods Forty rabbits were randomly divided into a normal group, model group, electroacupuncture (EA) group, and massage group, with 10 rabbits in each group. The CSA rabbit model was established by neck injection of sclerosing agent in all groups except the normal group. In the EA group, the left “Fengchi” (GB 20) and the 3rd-5th cervical vertebrae (C3-5) “Jiaji” (EX-B2) were selected for EA treatment. In the massage group, pushing manipulation with one finger was performed at 0.5 cm to the left side of the C3-5 spinous process and the tip of the transverse process. The vertebral artery blood flow was detected by laser Doppler. The levels of serum neuropeptide Y (NPY) and norepinephrine (NE) were determined by ELISA. The pathological morphological changes of vertebral arteries were observed by HE staining. The apoptosis of vertebral arteries and cerebella were detected by Tunel assay. The protein expressions of CHOP, Bcl-2, and Bax in vertebral arteries and cerebella were detected by Western blot. Results Vertebral artery blood flow was significantly decreased in all rabbits after modeling. Massage increased vertebral artery blood flow, decreased serum levels of NPY and NE which secreted by sympathetic nerves, improved vertebral artery lumen narrowing, intimal thinning, and mesenteric smooth muscle cell alignment. Moreover, these effects were superior to that in the EA group. In addition, the massage group significantly reduced the apoptotic index, decreased the CHOP and Bcl-2 associated X protein (Bax) protein expressions, and increased the B-cell lymphoma-2 (Bcl-2) protein expression in vertebral arteries and cerebella relative to the model group. Conclusion The treatment of CSA has a neuro-vascular regulatory mechanism. Massage can decrease the release of sympathetic neurotransmitters that constrict blood vessels and mitigate apoptosis induced by excessive endoplasmic reticulum stress (ERS) due to sympathetic excitation, so as to improve vertebral artery blood flow and serve as a treatment for CSA.
Optimization of PAS reaction and similar Schiff`s based methods for glycogen demonstration in liver tissue.
Authors: Abdellah Marwah Abdelrahman , Abdallah Maisa Aldai , Abdalrheem Abeer Babiker , Gubara Alobeid Mohammed , Batran Samah Abd-Elrahim , Zakout Yosef Mohamed-Azzam , Zakout Yosef Mohamed-Azzam
Published: February 2023

Purpose
Demonstration of glycogen in tissue has valuable diagnostic significance in several lesions, including certain tumors. Histochemical staining of glycogen with Schiff's dependent methods is affected by the type of fixative, the temperature of fixation, and oxidizing agents. This study aimed to evaluate different fixatives, temperatures of fixation, and oxidizing agents with variable durations of treatment to be used with Schiff's reagent for glycogen demonstration.
Methods
Archived paraffin blocks prepared from one rabbit's liver were used and 340 paraffin sections were stained with different oxidizers-Schiff methods.
Results
For tissues fixed at 4°C: 10% NBF, 80% alcohol, and Bouins's solution provided good staining results with PAS reaction. For tissues fixed at RT: both 10% NBF and 80% alcohol provided good staining results with PAS reaction. The other oxidizing agents provided poor results with all fixatives and temperature of fixation, with two exceptions of satisfactory staining results for 5% chromic acid for 10 minutes at both room temperature (RT) and 60°C.
Conclusion
Both 10% NBF and 80% alcohol seem to be the fixatives of choice for glycogen when the PAS reaction is used. However, Bouin's solution could provide good results at 4° C.
Possible thalassemia intermedia in a child (16th-18th centuries) from the westernmost part of Europe: potential association with malaria and past Islamic migration
Authors: Calleja Álvaro M. Monge , Lourenço Marina , Macedo Marta , Gaspar Rosa Ramos , Ribeiro M. Letícia , Santos Ana Luísa
Published: February 2023

This study aims to describe a non-adult individual with bone features suggestive of β-Thalassemia, diseases frequent in malaria-endemic regions today and in the past. The skeleton of a 5.5-6.5-year-old child exhumed from a 16th -18th centuries CE necropolis in Almeirim (Portugal) was examined macroscopically, with scanning electron microscope, and by conventional radiology and computed tomography. This individual shows frontoparietal diploic hyperplasia with a slight hair-on-end radiographic appearance and an exuberant serpiginous pattern. The orbital roofs have a plaque-like formation and facial bones display new bone proliferation and porosity. The teeth show caries, calculus deposition, anomalies on the four deciduous canine roots, and linear enamel hypoplasia on the first permanent right upper central incisor. The postcranial skeleton presents developmental delay, osteopenic trabecular appearances, cribra humeralis and cribra femoralis, the latter associated with malaria. A second non-adult individual (2.5–3.5 years old) had similar lesions in the cranium, raising the question if they were siblings. The lesions are consistent with β-Thalassemia intermedia, a homozygous or compound heterozygous hemoglobinopathy found in malaria endemic regions, such as Almeirim, due to the protective advantage conferred by β-Thalassemia carriers. Thalassemia presents a wide spectrum of lesions common in other hemolytic anemias, which difficult their diagnosis. Hopefully, biomolecular techniques will assist the diagnosis in skeletonized individuals. To the authors’ knowledge, this is the first possible case of thalassemia in the westernmost part of Europe, in a region currently with high prevalence of hemoglobinopathies, attributed to the past Islamic and sub-Saharan presence, and in an area historically affected by malaria.
Performance Emission and Combustion Characteristics of Ethanol Hydrogen Blends at MBT Spark Timing on Multi-cylinder SI Engine
Authors: Nitnaware Pravin , Suryawanshi Jiwak
Published: February 2023

Alternative fuels are the need of the current situation as conventional fuels are depleting very quickly and causing increase in amounts of pollution. Hydrogen as a clean fuel with Higher Calorific Value plays important role in increasing combustion characteristics. When compared with the performance of ethanol as a fuel, ethanol-hydrogen blends have demonstrated a 5% increase in power production, 15% reduction in hydrocarbon emissions, and 12% reduction in carbon dioxide emissions. All tests are conducted at speed of 2500, 3000, 3500, 4000, and 4500 rpm with the Wide-Open-Throttle (WOT) condition. CO & HC emissions are reduced using ethanol, whereas hydrogen addition enhanced the decreased power output, higher brake-specific fuel consumption and in cylinder pressure.
Exploring the Integration of Machine Learning Models in Programming Languages on GitHub: Impact on Compatibility to Address Them
Authors: slama faten , Ismail Imen , latrach lassaad
Published: February 2023

The complex field of accounting and how information technologies have impacted the way it's managed. It explains how many accounting tasks, such as data entry, billing, and expense management, can be automated using programming languages, and how visualization tools can help present the data clearly. The use of GitHub projects for accounting purposes can lead to improved efficiency and better financial decision-making. However, compatibility issues may arise on GitHub due to differences in programming languages, frameworks, or operating systems. These issues can be resolved by updating code or making changes, and by consulting the issues page, other repositories, or the language/library documentation. Other programming difficulties, such as performance problems or conflicts with other libraries, can also occur. A file extension approach (EF) for defining GitHub project domains in programming languages was presented, which involved sorting file extensions, computing percentage of each extension, and determining the dominant language. The study also investigated the connection between this EF approach and compatibility issues. The technique was used to recover over 200 deposits from GitHub, though the dataset content needs to be organized first.In this paper, we extend our previous work and describe in detail new algorithms and strategies to improve the efficiency and effectiveness of compatibility testing. To validate our approach, we have performed experiments and simulations on two widely-used middle libraries from the field of high-performance computing. For this paper, we restrict the compatibility testing to the build process (i.e. compilation and deployment) of a component with other components on which it depends, but we will extend the work to functional and performance testing in future work.
Effect of Music Therapy Treatment on Hospitalized Onco-Hematological Patients’ Anxiety, Sadness, Physical Discomfort, Mood and Quality of Life
Authors: Martí Patricia , Fontanals Irene , Funtané Joel , Canaletas Cristina , Sierra Jorge , Rodés Mariona , Mercadal-Brotons Melissa , González Iria , Novelli Silvana
Published: February 2023

Physical and psychological distress may be present when facing an onco-hematological diagnosis and undergoing complex therapies such as intensive chemotherapy, stem cell transplantation, and immunotherapy. Studies show the need for incorporating different therapeutic modalities to respond to patients’ physical and psychosocial needs. Aims: The purpose of this study is to evaluate the effectiveness of a music therapy treatment on mood, anxiety, depression, and physical discomfort of onco-hematological inpatient/hospitalized patients. Materials and Methods: Twenty-eight patients participated in a music therapy program. Treatment consisted of individual weekly music therapy sessions. Participants completed the following evaluation instruments before and after the intervention (pre/post-treatment): HADS (Hospital Anxiety and Depression Scale), POMS-A (Profile of Mood States - Short Form A-Version), Quality of Life EORTC QLQ-C30 (European Organization for Research and Treatment of Cancer-Quality of Life Core Questionnaire-30). A three-item Numerical Rating Scale (NRS) for Anxiety, Sadness, and Physical Discomfort was administered at the beginning and end of each session (pre/post-session). Results: The NRS results showed differences (p<0.05) between scores pre- and post-music therapy sessions in the three spheres: Anxiety, Sadness, and Physical Discomfort. Quality of life (QoL) is affected in almost all items, and patients might be anxious at a non-clinical level, but they do suffer from depressive moods as a clinical case.
Conclusion: Music therapy can positively change emotional distress and improve the mood of hematological patients. Despite the difficulties and limitations of this study, this preliminary report contributes to a greater understanding of the potential benefits of music therapy in hospitalized onco-hematological patients.
The quantification and tracing of harvest leakage in North Europe
Authors: Hu Junhui , Jåstad Eirik Ogner , Bolkesjø Torjus Folsland , Rørstad Per Kristian
Published: February 2023

The policy and measures that alter forest harvest level can be greatly offset by the presence of harvest leakage. Our study has quantified the leakage rates in four Nordic countries when a range of harvest shocks are introduced. A partial equilibrium forest sector model named the Nordic Forest Sector Model (NFSM) with 31 regions is applied for the purpose of the study. The roundwood leakage rates range from 58% to 91% in Norway, 73% to 91% in Sweden, 75% to 107% in Finland, and 59% to 106% in Denmark within the tested range. The leakage rates for sawlogs can be over 100% when the leakage of both sawnwood production and sawlogs happens the same time, and they can also be small if synergistic effect is present. The extra-Nordic leakage dominates the harvest leakage if harvest changes in one of the studied Nordics countries, and the leakage of the sawlogs harvest is a combined result of leakage of the raw materials (sawlogs) and the leakage of the production (sawnwood), while the leakage of pulpwood harvest is solely a result of leakage of the raw materials (pulpwood). The substitution of pulpwood by harvest residues and black liquor is significant in bioheat sector when harvest of pulpwood change. Therefore, we highly recommend that extra caution should be taken if a climate action may affect the level of the forest harvesting, and the harvest leakage effect on domestic industries, international trading should be awarded in open markets.
Assessment of Treatment Response to Dendritic Cell Vaccine in Patients with Glioblastoma using a Multiparametric MRI-Based Prediction Model
Authors: de Godoy Laiz Laura , Chawla Sanjeev , Brem Steven , Wang Sumei , O’Rourke Donald M , Nasrallah MacLean P. , Desai Arati , Loevner Laurie A. , Liau Linda M. , Mohan Suyash
Published: February 2023

Purpose
Autologous tumor lysate-loaded dendritic cell vaccine (DCVax-L) is a promising treatment modality for glioblastomas. The purpose of this study was to investigate the potential utility of multiparametric MRI-based prediction model in evaluating treatment response in glioblastoma patients treated with DCVax-L.
Methods
Seventeen glioblastoma patients treated with standard-of-care therapy + DCVax-L were included. When tumor progression was suspected and repeat surgery was being contemplated, we sought to ascertain the number of cases correctly classified as true progression (TP) + mixed response or pseudoprogression (PsP) from multiparametric MRI-based prediction model using histopathology/mRANO criteria as ground truth. Multiparametric MRI model consisted of predictive probabilities (PP) of tumor progression computed from diffusion and perfusion MRI-derived parameters. A comparison of overall survival (OS) was performed between patients treated with standard-of-care therapy + DCVax-L and standard-of-care therapy alone (external controls). Additionally, Kaplan-Meier analyses were performed to compare OS between two groups of patients using PsP, Ki-67, and MGMT methylation status as stratification variables.
Results
Multiparametric MRI model correctly predicted TP + mixed response in 72.7% of cases (8/11) and PsP in 83.3% (5/6) with an overall concordance rate of 76.5% with final diagnosis as determined by histopathology/mRANO criteria. There was a significant concordant correlation coefficient between PP values and histopathology/mRANO criteria (r = 0.54; p = 0.026). DCVax-L-treated patients had significantly prolonged OS than those treated with standard-of-care therapy (22.38 ± 12.8 vs. 13.8 ± 9.5months, p = 0.040). Additionally, glioblastomas with PsP, MGMT methylation status, and Ki-67 values below median had longer OS than their counterparts.
Conclusion
Multiparametric MRI-based prediction model can assess treatment response to DCVax-L in patients with glioblastoma.
The Downregulation of miR-509-3p Expression by Collagen Type XI Alpha 1-Regulated Hypermethylation Facilitates Cancer Progression and Chemoresistance via the DNA Methyltransferase 1/Small Ubiquitin-like Modifier-3 Axis in Ovarian Cancer Cells
Authors: Wu Yi-Hui , Huang Yu-Fang , Wu Pei-Ying , Chang Tzu-Hao , Huang Soon-Cen , Chou Cheng-Yang
Published: February 2023

Background
MicroRNAs are a group of small non-coding RNAs that are involved in development and diseases such as cancer. Previously, we demonstrated that miR-335 is crucial for preventing collagen type XI alpha 1 (COL11A1)-mediated epithelial ovarian cancer (EOC) progression and chemoresistance. Here, we examined the role of miR-509-3p in EOC.
Methods
The patients with EOC who underwent primary cytoreductive surgery and postoperative platinum-based chemotherapy were recruited. Their clinic-pathologic characteristics were collected, and disease-related survivals were determined. The COL11A1 and miR-509-3p mRNA expression levels of 161 ovarian tumors were determined by real-time reverse transcription-polymerase chain reaction. Additionally, miR-509-3p hypermethylation was evaluated by sequencing in these tumors. The A2780CP70 and OVCAR-8 cells transfected with miR-509-3p mimic, while the A2780 and OVCAR-3 cells transfected with miR-509-3p inhibitor. The A2780CP70 cells transfected with a small interference RNA of COL11A1, and the A2780 cells transfected with a COL11A1 expression plasmid. Site-directed mutagenesis, luciferase, and chromatin immunoprecipitation assays were performed in this study.
Results
Low miR-509-3p levels were correlated with disease progression, a poor survival, and high COL11A1 expression levels. In vivo studies reinforced these findings and indicated that the occurrence of invasive EOC cell phenotypes and resistance to cisplatin are decreased by miR-509-3p. The miR-509-3p promoter region (p278) is important for miR-509-3p transcription regulation via methylation. The miR-509-3p hypermethylation frequency was significantly higher in EOC tumors with a low miR-509-3p expression than in those with a high miR-509-3p expression. The patients with miR-509-3p hypermethylation had a significantly shorter overall survival (OS) than those without miR-509-3p hypermethylation. Mechanistic studies further indicated that miR-509-3p transcription was downregulated by COL11A1 through a DNA methyltransferase 1 (DNMT1) phosphorylation and stability increase. Moreover, miR-509-3p targets small ubiquitin-like modifier (SUMO)-3 to regulate EOC cell growth, invasiveness, and chemosensitivity.
Conclusion
The miR-509-3p/DNMT1/SUMO-3 axis may be an ovarian cancer treatment target.
Reconstruction of the shape and surface impedance from Cauchy data for the Helmholtz equation
Authors: Liu Ji-Chuan
Published: February 2023

In this paper, we are concerned with the coefficients identification for the Helmholtz equation. This problem which consists of determining an unknown inner boundary of an annular domain and surface heat transfer coefficient from boundary Cauchy data. We propose two reconstruction algorithms to simultaneously recover the shape and the surface impedance of the obstacle within a body. This problem is ill-posed, thus we apply regularization techniques in order to improve the corresponding approximation. Numerical experiments are presented for the reconstruction algorithms, which show that both the shape and the surface impedance can be reconstructed accurately.
AMS Mathematics Subject Classification 2010: 65N20,65N21.
Microgrid's regulation using a multiport SST
Authors: Ramirez Juan M , Arizaga-Ayala Francisco J , Alcala Janeth A.
Published: February 2023

A solid-state transformer controlled by a virtual synchronous generator is presented as an element capable of increasing the flexibility of electrical power distribution in a modern grid. With the advent of microgrids, the choice of strategies and devices capable of giving them flexibility has been of paramount importance. Emphasis has been shown on the transformer characteristics to regulate the frequency and voltage at its output terminals. This is very suitable for driving a wind turbine. Results are presented that demonstrate the versatility of such features working together.
Changes in Deiodinase Activity and Analysis of Related Influencing Factors in Growth Hormone-Secreting Pituitary Adenoma
Authors: Mo Caiyan , Wang Yao , Tong Tao , Chen Han , Guo Ying , Zhong Liyong
Published: February 2023

Purpose
Free triiodothyronine (FT3)/ free thyroxine (FT4) ratio is often considered as an indicator of deiodinase activity in the context of multiple diseases. We aimed to investigate the changes in deiodinase activity in growth hormone-secreting pituitary adenoma (GHPA) patients at high levels of growth hormone (GH) / insulin-like growth factor-1 (IGF-1) and analyze related influencing factors.
Methods
A retrospective cross-sectional study was conducted to collect demographic and clinical data of 128 GHPA patients with normal thyroid function from the Department of Endocrinology, Beijing Tiantan Hospital, Capital Medical University during 2015-2022. Pearson correlation test and linear regression analysis were used to analyze the relationship between FT3/ FT4 ratio and GH, IGF-1, insulin-like growth factor binding protein-3 (IGFBP-3), homeostasis model assessment of insulin resistance(HOMA-IR), body mass index (BMI) and age.
Results
1. FT3/FT4 ratio was positively correlated with GH and IGFBP-3, but had no significant correlation with IGF-1. 2. FT3/FT4 ratio was positively correlated with BMI and negatively correlated with age. 3. FT3/FT4 ratio was positively correlated with fasting insulin (FINS) and HOMA-IR, but had no significant correlation with fasting C-peptide (FCP). 4. In multivariate analysis, FT3/FT4 ratio was independently associated with age and BMI.
Conclusion
In GHPA patients, high circulating levels of GH/IGF-1/IGFBP-3 system, high insulin level and elevated BMI may increase the activity of deiodinase, leading to increased peripheral T3 level, which may be a compensation mechanism of the body. Besides, deiodinase activity decreases with age, suggesting that elderly GHPA patients should be alerted to the risk of hypothyroidism.
Numerical analysis for thermal performance of magnetized radiative nanofluid with variable density
Authors: Khan Aamir Abbas
Published: February 2023

The majority of study has focused on fluid surfaces with constant surface densities and low ambient temperature differentials. Due to the greater temperature differential with radiation, the density is believed to be an exponential function of temperature. The magnetohydrodynamics (MHD) acts like a coating material to protect technological devices from excessive heating. The main goal of this technique is to prevent excessive heating in high temperature systems by utilising the effects of changing density, MHD, and radiation on the heat and mass properties of nanofluid across stretched sheets. This is the first instance of a density issue with a nanofluid across a stretching surface. For a smooth algorithm and integration, the coupled partial differential equations (PDEs) of the current nanofluid mechanism are transformed into coupled nonlinear ODEs with defined stream functions and similarity variables. By using the Keller Box technique, the modified ODEs are again translated in a comparable format for numerical results. The MATLAB program is used to derive the numerical results, which are then presented in graphs and tabular form. For this phenomenon, the slopes of the velocity, temperature, and concentration profiles have been plotted for various parameters. As n increases, two forces will act on the nanofluid, the first of which causes the velocity to increase due to an increase in buoyancy forces and the second of which causes the velocity to decrease due to a decrease in temperature.
Disease-Specific and Gender-Dependent Gut-Microbiome Features in Chinese Colon Polyps Patients
Authors: Chen Binbin , Liu Ming , Liu Hui , Shen Yang , Li Jiaorong , Wang Yanan , Song Xintong , Wei Zhixing , Liu Jingyao , Wei Xiangrui , Liu Lanzheng , Zhao Xiulan , Zhang Mingbao , Zhou Jun
Published: February 2023

Background/Objectives
Colon polyps (CP) is a chronic disease prevalent in the middle-aged adults. To improve the diagnosis, treatment and prevention of CP incidence, we explored the disease-specific and gender-dependent features of gut-microbiome in Chinese CP patients.
Methods
We enrolled 124 CP patients (40 females and 84 males) that contain 89 single polyps cases and 35 multiple polyps cases. Their basic information, blood chemistry and gut microbiome were analyzed to find out disease-specific and gender-dependent features.
Results
We found that smaller blood platelet size was associated with multiple colon polyps type (χ2 p < 0.05). Less breakfast frequency and more alcohol intake showed logistic association with disadvantageous blood biochemistry, including serum triglyceride level, low-density lipoprotein, high-density lipoprotein and fasted blood glucose levels (Chi square p < 0.01). CP patients had significantly higher gut-microbiome diversity than alcoholic fatty liver diseases (n = 12) but less than that observed in the ulcerative colitis (UC) patients (n = 20). Bioinformatics analysis showed that CP gut-microbiome is linked with higher cancer risk than UC. The gut-microbiome of CP patients are featured by Prevotellaceae and Paraprevotellaceae. We further found that inflammatory/infectous related Alcaligenaceae, Enterobacteriaceae and Erysipeltrichaceae were abundant in male CP patients, whereas neutral/beneficial Barnesiellaceae, Lachnospiraceae, Odoribacteraceae and Rikenellaceae were abundant in female CP patients.
Conclusion
To summarize, gut-microbiome demonstrated to be highly gender-dependent and disease-specific in CP patients and our data provides valuable reference to the gut-microbiome centered treatment of CP patients of different genders.