bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic and Chromosomal Aberrations and Their Clinical Significance in Renal Neoplasms
Authors: Yap Ning Yi , Rajandram Retnagowri , Ng Keng Lim , Pailoor Jayalakshmi , Fadzli Ahmad , Gobe Glenda Carolyn
Published: September 2015

The most common form of malignant renal neoplasms is renal cell carcinoma (RCC), which is classified into several different subtypes based on the histomorphological features. However, overlaps in these characteristics may present difficulties in the accurate diagnosis of these subtypes, which have different clinical outcomes. Genomic and molecular studies have revealed unique genetic aberrations in each subtype. Knowledge of these genetic changes in hereditary and sporadic renal neoplasms has given an insight into the various proteins and signalling pathways involved in tumour formation and progression. In this review, the genetic aberrations characteristic to each renal neoplasm subtype are evaluated along with the associated protein products and affected pathways. The potential applications of these genetic aberrations and proteins as diagnostic tools, prognostic markers, or therapeutic targets are also assessed.
Assessing Uncertainty in A2 Respiratory Syncytial Virus Viral Dynamics
Authors: González-Parra Gilberto , Dobrovolny Hana M.
Published: September 2015

Respiratory syncytial virus (RSV) is the most common cause of bronchiolitis and pneumonia in children younger than 1 year of age in the United States. Moreover, RSV is being recognized more often as a significant cause of respiratory illness in older adults. Although RSV has been studied both clinically and in vitro, a quantitative understanding of the infection dynamics is still lacking. In this paper, we study the effect of uncertainty in the main parameters of a viral kinetics model of RSV. We first characterize the RSV replication cycle and extract parameter values by fitting the mathematical model to in vivo data from eight human subjects. We then use Monte Carlo numerical simulations to determine how uncertainty in the parameter values will affect model predictions. We find that uncertainty in the infection rate, eclipse phase duration, and infectious lifespan most affect the predicted dynamics of RSV. This study provides the first estimate of in vivo RSV infection parameters, helping to quantify RSV dynamics. Our assessment of the effect of uncertainty will help guide future experimental design to obtain more precise parameter values.
Overexpression ofGPC6andTMEM132Din Early Stage Ovarian Cancer Correlates with CD8+ T-Lymphocyte Infiltration and Increased Patient Survival
Authors: Karapetsas Athanasios , Giannakakis Antonis , Dangaj Denarda , Lanitis Evripidis , Kynigopoulos Spyridon , Lambropoulou Maria , Tanyi Janos L. , Galanis Alex , Kakolyris Stylianos , Trypsianis Gregorios , Coukos George , Sandaltzopoulos Raphael
Published: September 2015

Infiltration of cytotoxic T-lymphocytes in ovarian cancer is a favorable prognostic factor. Employing a differential expression approach, we have recently identified a number of genes associated with CD8+ T-cell infiltration in early stage ovarian tumors. In the present study, we validated by qPCR the expression of two genes encoding the transmembrane proteins GPC6 and TMEM132D in a cohort of early stage ovarian cancer patients. The expression of both genes correlated positively with the mRNA levels ofCD8A, a marker of T-lymphocyte infiltration [Pearson coefficient: 0.427 (p=0.0067) and 0.861 (p<0.0001), resp.].GPC6andTMEM132Dexpression was also documented in a variety of ovarian cancer cell lines. Importantly, Kaplan-Meier survival analysis revealed that high mRNA levels of GPC6 and/or TMEM132D correlated significantly with increased overall survival of early stage ovarian cancer patients(p=0.032). Thus,GPC6andTMEM132Dmay serve as predictors of CD8+ T-lymphocyte infiltration and as favorable prognostic markers in early stage ovarian cancer with important consequences for diagnosis, prognosis, and tumor immunobattling.
Analysis of Material Handling Safety in Construction Sites and Countermeasures for Effective Enhancement
Authors: Anil Kumar C. N. , Sakthivel M. , Elangovan R. K. , Arularasu M.
Published: September 2015

One of many hazardous workplaces includes the construction sites as they involve several dangerous tasks. Many studies have revealed that material handling equipment is a major cause of accidents at these sites. Though safety measures are being followed and monitored continuously, accident rates are still high as either workers are unaware of hazards or the safety regulations are not being strictly followed. This paper analyses the safety management systems at construction sites through means of questionnaire surveys with employees, specifically referring to safety of material handling equipment. Based on results of the questionnaire surveys, two construction sites were selected for a safety education program targeting worker safety related to material handling equipment. Knowledge levels of the workers were gathered before and after the program and results obtained were subjected to a t‐test analysis to mark significance level of the conducted safety education program.
ANÁLISE DO GRAU DE INTEGRAÇÃO ENTRE OS PAÍSES DO MERCOSUL A PARTIR DA HIPÓTESE DA PARIDADE DA TAXA DE JUROS REAL
Authors: Sacchetti Lívia Semensato , Ferreira Alex Luiz
Published: September 2015

Verificou-se formalmente o grau de integração conjunta dos mercados de bens e ativos entre os países do Mercosul: Argentina, Brasil, Paraguai e Uruguai. A investigação foi realizada para o período entre julho de 1995 a setembro de 2011, por meio da análise das séries de tempo dos diferenciais de taxa de juros reais entre os mesmos. O conjunto dos resultados dos testes bilaterais aponta na direção de estacionariedade dos diferenciais dos países-membros, sendo esses corroborados pelos dados em painel. As medidas de persistência estimadas evidenciam que o processo de integração combinada aumentou ao longo do período amostral, ainda que lentamente.
Atrações e prazeres visuais em um pornô feminino
Authors: Baltar Mariana
Published: September 2015

Este artigo correlaciona os conceitos de excesso e atrações como estratégicos para refletir sobre processos de engajamento e afetação no campo da pornografia que desestabilizam morais tradicionais em direção a uma política de gêneros. Nesse sentido, mobiliza-se uma lógica de excesso de atrações que estabelece um jogo ambivalente de recusa e adesão aos códigos genéricos mais básicos da pornografia. Os argumentos são empreendidos a partir da análise de Dirty Diaries, um projeto declaradamente associado ao campo da pornografia feminista empreendido com apoio do Swedish Film Institut.
Resistência política e ficção cinematográfica: Argentina 1976-1989.
Authors: Lusnich Ana Laura
Published: September 2015

O artigo tem dois objetivos centrais. Um deles é discernir as características textuais e semânticas do conjunto de filmes alegórico-metafóricos realizados na Argentina na época da última ditadura militar e na etapa inicial da pós-ditadura. Em segunda instância, propõe-se a analisar dois filmes emblemáticos dessa tendência dedicados a tematizar e representar de forma crítica e reflexiva as figuras das vítimas e dos algozes: Últimos días de la víctima (Últimos dias da vítima, 1982), de Adolfo Aristarain, e Hay unos tipos abajo (Existem alguns caras para baixo, 1985), de Rafael Filipelli e Emilio Alfaro.
Legislação em saúde: um estudo sobre a iniciativa de projetos de lei no Estado do Acre
Authors: Teston Luci Maria
Published: September 2015

O artigo analisa as atuações dos poderes Executivo e Legislativo no Estado do Acre quanto à formulação de propostas políticas para a saúde a partir de 1999, comparando duas legislaturas. Parte-se do princípio de que o Executivo dispõe de amplo poder de agenda, o qual permite definir temas essenciais a serem apreciados pelo Legislativo, bem como determinar os passos e a sequência de procedimentos a serem seguidos ao longo do processo decisório. O estudo foi descritivo e realizado a partir de consulta a documentos da Assembleia Legislativa do Estado do Acre com acesso público. Foram identificados os projetos de lei aprovados pela Assembleia, sendo analisados por autoria, tempo de tramitação e natureza, considerando-se o contexto político-institucional. Das 93 matérias de autoria do Legislativo aprovadas entre 1999 a 2002, 20,4% trataram de temas relacionados à saúde, em especial a medicamentos, vacinas, insumos e produtos para a saúde. No período seguinte (2003-2006), das 294 proposições aprovadas, 6,8% estiveram relacionadas à saúde, envolvendo principalmente políticas, planos, programas e projetos. O estudo sugere que houve, entre os dois períodos analisados, uma mudança na natureza dos projetos de autoria do Legislativo aprovados. Os parlamentares, na segunda legislatura, fizeram uso de uma agenda leve, ao priorizarem questões honoríficas e simbólicas.
Violações de direitos humanos no Presídio do Roger, no Estado da Paraíba
Authors: Gomes Navaroni Soares , Kölling Gabrielle , Balbinot Rachelle Amália Agostini
Published: September 2015

O presente trabalho tem por objetivo analisar a aplicação dos direitos humanos no sistema carcerário brasileiro, em especial no que tange ao direito humano à saúde, especificamente no Presídio do Roger, no Estado da Paraíba. Sabe-se que os objetivos da sanção imposta ao delinquente são prevenção e ressocialização; todavia, a realidade carcerária brasileira tem se mostrado incompatível com estas finalidades, em razão das condições a que são submetidos os condenados que cumprem pena nos diversos estabelecimentos penais brasileiros, sem a menor observância dos direitos humanos que lhes são assegurados. Trata-se de um estudo descritivo-analítico, que perpassa o direito humano à saúde, seus aspectos normativos e o estado da arte do sistema carcerário em relação a este direito.
CONTEXTUALIZAÇÃO HISTÓRICA DAS POLÍTICAS DE COTAS EM UNIVERSIDADES PÚBLICAS FEDERAIS NO CENÁRIO DE MUDANÇAS NO MODELO POLÍTICO-SOCIAL DO BRASIL DA ÚLTIMA DÉCADA (2003-2013)
Authors: Lemes Maurício Buosi , Severi Fabiana Cristina
Published: September 2015

Trata-se de uma sucinta revisão bibliográfica que pretende apresentar um panorama das recentes transformações dos modelos de Estado implementados no país, capazes de engendrar as políticas de cotas no ensino superior público.O ponto de partida da investigação é o Brasil a partir dos processos de redemocratização gestados com a queda da Ditadura Militar (1964-1985) e que culminaram na promulgação da Constituição Federal de 1988. Objetivou-se compreender, à luz do método histórico-dialético de análise do social, as características, continuidades e rupturas dos modelos de Estado constituídos a partir dessa conjuntura, com o intuito de captar o movimento de surgimento das políticas de cotas nas universidades federais, seus fundamentos e horizontes.
REGULAÇÃO DE INFRAESTRUTURA POR CONTRATO
Authors: Gasiola Gustavo Gil
Published: September 2015

O presente artigo pretende analisar a regulação contratual de infraestrutura. Para tanto, explora o conceito de infraestrutura e seus desafios regulatórios. Depois, diferencia-se a regulação contratual da regulação discricionária. Por fim, discute-se a dinâmica entre os problemas regulatórios das infraestruturas e a regulação contratual.
DA JUDICIALIZAÇÃO DOS DIREITOS SOCIAIS À NECESSIDADE DE RESPEITO ADMINISTRATIVO AOS PRECEDENTES JUDICIAIS: UMA ANÁLISE EMPÍRICA DA JURISPRUDÊNCIA DO TRF4 SOBRE DIREITO À SAÚDE
Authors: Faria Luzardo
Published: September 2015

Esse artigo objetiva encontrar soluções para o problema do ativismo judicial e da judicialização dos direitos fundamentais sociais. Com o advento da Constituição Federal de 1988 e a instituição do paradigma de Estado Social de Direito, surgiram incontáveis ações judiciais com o intento de condenar a Administração Pública à efetivação de tais direitos.  Realizou-se uma pesquisa empírica em cima da jurisprudência do Tribunal Regional Federal da 4ª Região dos casos de judicialização do direito fundamental social à saúde em que havia o pedido para concessão judicial de medicamento para tratamento de Hepatite C Crônica.
DESCONSIDERAÇÃO ADMINISTRATIVA DA PERSONALIDADE SOCIETÁRIA – COMPATIBILIDADES E POSSIBILIDADES DA LEI ANTICORRUPÇÃO
Authors: Pinho Clóvis Alberto Bertolini de
Published: September 2015

O presente artigo tem como objetivo principal analisar a desconsideração administrativa da pessoa jurídica em âmbito da Administração Pública, de maneira especial a partir da análise da recém-promulgada Lei Anticorrupção (Lei Federal nº 12.846/2013). Também examina de maneira mais detida a necessidade de regulamentação da Lei Anticorrupção, suas possibilidades de aplicação, os conflitos com a jurisdição penal, e comenta a previsão específica de desconsideração da personalidade societária na Lei 12.846/2013.
ANÁLISE DE IMPACTO REGULATÓRIO: NOTAS SOBRE A OCDE E SOBRE O BRASIL
Authors: Dias Bruno Fernandes
Published: September 2015

O artigo inicialmente exemplifica como a Análise de Impacto Regulatório (AIR) já se tornou um ponto de consternação para as pessoas sujeitas à regulação, em razão dos muitos efeitos que as decisões dos reguladores têm na vida cotidiana e econômica da população. Do que está na pauta de discussão atual o estudo regride para o histórico da AIR na OCDE, apresentando dados que demonstram em quais áreas do direito, e com que intensidade, essa técnica tem sido utilizada. O item seguinte é dedicado ao desenvolvimento teórico da AIR, explorando-se as suas características principais e as premissas conceituais utilizadas em análises de impacto. Ao final, trata-se do desenvolvimento da AIR no Brasil, com um breve relato sobre o histórico legislativo, uma visão da doutrina nacional e o exame de iniciativas já tomadas e em curso no âmbito de agências reguladoras nacionais.
Communication as Spatial Production
Authors: Lindell Johan
Published: September 2015

The founders of the interdisciplinary field of communication geography argue that the field carries the potential to provide a processual view of communication as spatial production. This article sets out to delineate this underexplored aspect of communication geography. The aim is to expand the research agenda of communication geography by acknowledging the role of everyday social interaction on the one hand, and media environments on the other, in producing and maintaining peoples’ taken-for-granted senses of space. This focus is guided by combining central insights of social phenomenology and medium theory. In synthesizing these positions, a research agenda emerges that emphasizes the capacity of media to “mold” the scope and character of communication that in turn maintain the scope and character of taken-for-granted space in everyday reality.
Association between serum uric acid level and metabolic syndrome components
Authors: Nejatinamini Sara , Ataie-Jafari Asal , Qorbani Mostafa , Nikoohemat Shideh , Kelishadi Roya , Asayesh Hamid , Hosseini Saeed
Published: September 2015

Background

Serum uric acid levels is reported to be associated with a variety of cardiometabolic risk factors; however, its direct association with metabolic syndrome (MetS) remains controversial. Thus, we examined the association of serum uric acid concentrations with the MetS components.

Methods

MetS was defined according to the National Cholesterol Education Program (NCEP) criteria. This case–control study comprised 101 non-smoking individuals (41 in the MetS group and 60 in the non-MetS group). Blood pressure, fasting plasma glucose, insulin, HOMA-IR, lipid profiles, uric acid, and anthropometric measures were determined, and body composition was assessed by using bioelectrical impedance analysis (BIA).

Results

After adjustment for confounding factors, serum uric acid was significantly higher in MetS group than non-MetS group (5.70 ± 1.62 vs 4.97 ± 1.30 mg/dL, respectively, P = 0.001). After controlling for age, sex and body mass index in partial correlation analysis, uric acid was positively correlated with triglycerides, and negatively with HDL-C. In multiple logistic regression analysis, every 1 mg/dl elevation in the serum uric acid level increased the risk of MetS approximately by 2-folds (OR: 2.11, 95 % CI: 1.30-3.41).

Conclusion

This study showed that those individuals with MetS have higher uric acid levels; the association of uric acid and MetS components supports that it might be an additional components of MetS.
Low molecular heparin for cancer-associated venous thromboembolism – still the “CATCH of the day“?
Authors: Matzdorff A.
Published: September 2015

In December 2014 the CATCH study was presented at the annual meeting of the American Society of Hematology. CATCH is a randomized controlled trial comparing the low molecular weight heparin tinzaparin with warfarin for 6 months extended treatment (=secondary prophylaxis) of cancer-associated venous thromboembolism (VTE). 6.9 % of patients in the tanzaparin arm experienced recurrent symptomatic and asymptomatic VTE compared with 10 % in the warfarin arm, this difference was statistically not significant. The difference became significant when only symptomatic VTEs were compared. There was no difference in the incidence of major bleeding events, but significantly fewer patients experienced clinically relevant non-major bleeding with tinzaparin than warfarin. The CATCH study is so far the largest study on extended treatment of cancer-associated VTE. It supports the guideline recommendation that low molecular weight heparins should be preferred to vitamin K antagonists for anticoagulation of cancer-associated VTE.
Moscow Educational Establishments� Rating: Aims, Tools, Results
Authors: ��������  , Chernobay Elena
Published: September 2015

The article discusses the educational institutions� rating on the example of Moscow education system, details the rating criteria, and justifies the objective

indicators of ranking educational organizations of metropolitan area.
Supporting couple relationships to improve family stability
Authors: Fisher Maggie
Published: September 2015

Maggie Fisher introduces a perinatal pilot that supports the couple relationship as they become new parents and highlights the key role health visitors can play.
An outbreak of rotten lamb syndrome associated with Clostridium sordellii
Authors: Jones Alwyn Ll , Howie Fiona , Caldow George L
Published: September 2015

The term ‘rotten lamb syndrome’ describes a condition in peri-parturient sheep where a fetus dies in utero and undergoes bacterial putrefaction. This case study details an investigation into an outbreak of rotten lamb syndrome associated with a high rate of vaginal prolapse on a farm in south-east Scotland. Clostridium sordellii was identified in the fetal tissues and uterine wall in five of six ewes that were euthanased and examined by necropsy. These findings suggest that C. sordellii associated with vaginal prolapse plays a role in the development of rotten lambs in utero and that the use of a multivalent clostridial vaccine containing C. sordellii toxoid could be beneficial in flocks that experience losses due to rotten lamb syndrome.
Implementing your plan
Authors: Gallagher Josie
Published: September 2015

Members of the school leadership team are often challenged to implement whole-school strategies. Josie Gallagher outlines the four key principles that will help your implementation plan to succeed
Prevalence of paternal perinatal depressive mood and its relationship with maternal depression symptomatology: An Italian study
Authors: Cattaneo Maria Caterina , Macchi Elena Alessandra , Salerno Roberta , Chiorino Valentina , Roveraro Sara , Barretta Francesco , Fontana Camilla Barbara , Mosca Fabio
Published: September 2015

Background: Literature shows that the birth of a child is a vulnerability moment for the mental well-being of both parents.Objectives: estimate the prevalence of a depressive symptomatology in an Italian sample of new fathers during the first six months postpartum and provide its association with maternal mood.Methods: 244 neo- parents filled the Italian version of the Edinburgh Postnatal Depression Scale (EPDS) and a General Information Questionnaire between 2/5 days after delivery during the hospitalization in the Mother-infant Department of an Italian hospital and after 2 and 6 months postpartum by mailed.Results: in the first week postpartum, 6.65% of fathers had a EPDS score â‰¥ 10, this percentage decreases to 2.63% at 2 months and 2.59% at 6 months postpartum. Previous history of anxiety/panic attacks in fathers was a risk factor for a depressive symptomatology of them after 2 and 6 months postpartum. Paternal and maternal depressive mood were correlated most of the times and associated especially after births when a depressed father is more than 5 time frequently associated to a depressed mother 2 months later.Conclusions: experimental data suggest that neo-fathers experiment depressive symptoms especially in the immediate postpartum when their mood is associated with maternal mood in a significant way. Health care professionals should pay great attention to the neo-parental couple mood.
Reflective practice programme for registered nurses in training hospitals in Windhoek
Authors: N. Nelumbu Lucia
Published: September 2015

Problems or incidents occurring in clinical settings are often seen as indicators of poor nursing care and even indicators of a lack of reflective practice skills. A qualitative, explorative, phenomenological, descriptive and contextual approach was conducted to explore and describe how reflective practice is practised by registered nurses in training hospitals in Windhoek. The findings revealed inadequate knowledge of reflective practice among registered nurses. Based on these findings the educational programme was developed to facilitate learning and application of reflective practice in clinical practice. This paper presents the description of an educational programme that was developed to facilitate learning and practice of reflective practice by registered nurses to make a difference to their patientsâ€™ care.
Noise properties of textile, capacitive EEG electrodes
Authors: Asl Sara Nazari , Ludwig Frank , Schilling Meinhard
Published: September 2015

The rigid surface of the conventional PCB-based capacitive electrode produces an undefined distance between the skin and the electrode surface. Therefore, the capacitance introduced by them is uncertain and can vary from electrode to electrode due to their different positions on the scalp. However, textile electrodes which use conductive fabric as electrode surfaces, are bendable over the scalp. Therefore, it provides a certain value of the capacitance which is predictable and calculable accurately if the effective distance to the scalp surface can be determined. In this paper noise characteristics of textile electrodes with different fabric sizes as electrode’s surface and capacity calculations related to each size are presented to determine the effective distances for each electrode size.
Virtualizing clinical cases of atrial flutter in a fast marching simulation including conduction velocity and ablation scars
Authors: Trächtler J. , Oesterlein T. , Loewe A. , Poremba E. , Luik A. , Schmitt C. , Dössel O.
Published: September 2015

Diagnosis of atrial flutter caused by ablation of atrial fibrillation is complex due to ablation scars. This paper presents an approach to replicate the clinically measured flutter circuit in a dynamic computer model. In a first step, important anatomical features of the flutter circuit are extracted manually based on the clinical measurement. With the help of this information, the electrical excitation propagation is simulated on the atrial geometry using the fast marching method. The simulated flutter circuit is used to estimate the global and local conduction velocity by approximating it iteratively. The parameterized flutter simulation is supposed to support the physician during diagnosis and treatment of atrial flutter.
Understanding the cellular mode of action of vernakalant using a computational model: answers and new questions
Authors: Loewe Axel , Xu Yan , Scholz Eberhard P. , Dössel Olaf , Seemann Gunnar
Published: September 2015

Vernakalant is a new antiarrhythmic agent for the treatment of atrial fibrillation. While it has proven to be effective in a large share of patients in clinical studies, its underlying mode of action is not fully understood. In this work, we aim to link experimental data from the subcellular, tissue, and system level using an in-silico approach. A Hill’s equation-based drug model was extended to cover the frequency dependence of sodium channel block. Two model variants were investigated: M1 based on subcellular data and M2 based on tissue level data. 6 action potential (AP) markers were evaluated regarding their dose, frequency and substrate dependence. M1 comprising potassium, sodium, and calcium channel block reproduced the reported prolongation of the refractory period. M2 not including the effects on potassium channels reproduced reported AP morphology changes on the other hand. The experimentally observed increase of ERP accompanied by a shortening of APD90 was not reproduced. Thus, explanations for the drug-induced changes are provided while none of the models can explain the effects in their entirety. These results foster the understanding of vernakalant’s cellular mode of action and point out relevant gaps in our current knowledge to be addressed in future in-silico and experimental research on this aspiring antiarrhythmic agent.
Image guided surgery innovation with graduate students - a new lecture format
Authors: Friebe Michael , Traub Jörg
Published: September 2015

In Image Guided Surgeries (IGS), incremental innovation is normally not a technology push (technology delivered) but rather a pull (by learning and working with the clinical users) from understanding how these surgeries are performed. Engineers need to understand that only through proper observation, procedure know-how and subsequent analysis and evaluation, clinically relevant innovation can be generated. And, it is also essential to understand the associated health economics that could potentially come with new technological approaches. We created a new lecture format (6 ECTS) for graduate students that combined the basics of image guided procedures with innovation tools (Design Thinking, Lean Engineering, Value Proposition Canvas, Innovation Games) and actual visits of a surgical procedure. The students had to attend these procedures in small groups and had to identify and work on one or more innovation projects based on their observations and based on a prioritisation of medical need, pains and gains of the stakeholders, and ease of implementation. Almost 200 graduate students completed this training in the past 5 years with excellent results for the participating clinicians, and for the future engineers. This paper presents the lecture content, the setup, some statistics and results with the hope that other institutions will follow to offer similar programs that not only help the engineering students identify what clinically relevant innovation is (invention x clinical implementation), but that also pave the path for future interdisciplinary teams that will lead to incremental and disruptive innovation.
Three-Phase CFD-Model for Trickle Bed Reactors
Authors: Gorshkova Elena , Manninen Mikko , Alopaeus Ville , Laavi Helena , Koskinen Jukka
Published: September 2015

Comprehensive CFD-model for reactive flow of gas and liquid in porous catalyst beds was developed and numerically tested. The three phase trickle-bed process involving both gas and liquid phases and the fixed bed of porous catalyst particles includes hydrodynamic forces, mechanical and capillary dispersion, and wetting efficiency.

In the present work, the model was extended to include reactions, mass transfer and heat transfer. The stationary gas and liquid inside the porous particles were modeled separately from the bulk gas and liquid phases flowing outside the particles, with convective and diffusive mass transfer between the inner and outer fluids. Reactions were assumed to take place inside the catalyst particles. The process modeled in this work was the hydrogenation of octene in Ni/Al2O3 reactor. The reaction is highly exothermic resulting in evaporation and condensation of the components.

All submodels were implemented in Fluent software. Numerical tests were carried out to show that the CFD model allows the investigation of local variations in the reactor, caused for example by bed drying or the effects of irregular liquid feed.
Joule Heating Effect in Constant Voltage Mode Isotachophoresis in a Microchannel
Authors: Shim Jaesool , Dutta Prashanta
Published: September 2015

Microchip ITP (isotachophoresis) is getting popularity as a preparative technique for preconcentration and separation of chemical species and/or ions in liquid phase. In constant voltage mode ITP, generally a high electric potential difference is applied to a discontinuous buffer for faster and higher resolution separation. However, the higher current from the applied electric field induces Joule heating in the buffer which modifies the mobility and diffusion coefficient of analytes in the system. This change in mobility and diffusion coefficient strongly influences the transient separation process in ITP. In this study the effect of Joule heating on separation behavior of analyte compounds has been presented in a constant voltage mode ITP where two chemical species are separated from an initial mixture. The model is based on mass, energy, and charge conservation and electroneutrality condition in the system. A set of nonlinear governing equations are solved numerically for temperature dependent properties such as diffusion coefficient, effective electrophoretic mobility, and thermal conductivity using a finite volume based model. Numerical results suggest that for temperature dependent properties of control parameters, the separation speed of analytes is significantly different from that of constant temperature case. In constant voltage mode ITP, the temperature peak forms at the location of trailing electrolyte, and its influence propagates toward the direction of band movement as separation proceeds.
Volatile constituents of Dietes bicolor (Iridaceae) and their antimicrobial activity
Authors: Ayoub Iriny M. , Youssef Fadia S. , El-Shazly Mohamed , Ashour Mohamed L. , Singab Abdel Nasser B. , Wink Michael
Published: September 2015

Volatile oils from the leaves, flowers and rhizomes of Dietes bicolor (Steud.) Sweet ex Klatt (Iridaceae) were analyzed using GLC/FID and GLC/MS. A total of 84 compounds were identified accounting for 94.65, 95.63 and 87.09% in the hydrodistilled oils from flowers, leaves and rhizomes, respectively. Spathulenol (48.44%) represented the major component in the leaf oil, followed by dihydro-edulan I (6.25%), cubenol (6.00%) and τ-cadinol (5.90%). For the flower and rhizome oils, fatty acids, their esters, aliphatic hydrocarbons and their derivatives predominate. The antimicrobial activity of both leaf and flower oils was investigated against four bacteria in addition to four fungi using the micro-broth dilution method. The leaf oil showed a more potent antimicrobial activity as compared to the flower oil against most of the assessed bacteria and fungi, with higher activities against Gram- positive organisms showing MIC values of 115 and 460 μg/ml for Bacillus subtilis and Streptococcus pneumonia, respectively. Gram-negative bacteria were generally less susceptible (MIC > 2 mg/ml for both oils against Escherichia coli) and being completely ineffective against Pseudomonas aeruginosa. A relevant antifungal potency of the leaf oil against Geotrichum candidum and Syncephalastrum racemosum was also observed with MIC values of 115 and 920 μg/ml, respectively.
PENGARUH HARGA BAWANG MERAH TERHADAP PRODUKSI BAWANG MERAH DI JAWA TENGAH
Authors: Pranata Ade , Umam Ahmad Takhlishul
Published: September 2015

Onion prices are fluctuating in Central Java, causing profits onion farmers uncertain. So that when the price drops causing the farmers had a loss and decrease cultivating intensity in the next season. The data in this study using quantitative data using OLS (Ordinary Least Square) with the classical assumption: multicoloniarity, autocorrelation, heteroscedasticity, and test for normality. The test equipment are using F-test, t test, and R2. From the test results of significance (F test) showed that the independent variables simultaneously significant effect on dependent variable with the calculated F value of 7.594314 and 0.007849 probability <0.05. The results of the partial model test (t test) showed that the price of onion variables significantly influencing the production of onion variables with probability 0.0078 <α (0.05) and had a negative impact, with coefficient of -3,148.617. Coefficient of determination on this results is 0.117569. it could be explained that onion production is influenced by variables onion prices by 11.76% while the remaining 88.24% influenced by other variables outside the model. Recomendate : The government needs to control the price that farmers do not lose money when prices fall and can continue cultivating in the next period. So that the onion production is relatively stable.

 
STRATEGI PENGEMBANGAN INDUSTRI KECIL CARICA
Authors: Permadi Adi
Published: September 2015

Tujuan penelitian ini untuk mengetahui bagaimana profil industri kecil carica di Kabupaten Wonosobo serta untuk mengetahui strategi pengembangan apa yang bisa digunakan. Variabel yang diteliti adalah profil industri yang meliputi sumber daya manusia, permodalan, teknologi, dan pemasaran. Metode analisis data yang digunakan adalah metode analisis deskriptif dan analisis SWOT. Berdasarkan hasil penelitian menunjukkan bahwa profil industri kecil carica di Kabupaten Wonosobo pada tahun 2014 ada 15 unit usaha. Ada beberapa prioritas strategi pengembangan yaang dilakukaan yaitu strategi SO dengan meningkatkan kualitas SDM, memanfaatkan tenaga kerja dari daerah sekitar, dan mengoptimalkan lokasi industri yang strategis. Strategi WO menyiapkan stok produk carica, mengoptimalkan produk carica, dan mengoptimalkan pelatihan dari dinas terkait. Strategi ST dengan meningkatkan kualitas ciri khas produk carica,peranan pemerintah dalam hal mengantisipasi bencana longsor di Dieng, dan melakukan inovasi produk carica. Strategi WT dengan meningkatkan kemampuan manajerial pengusaha, menaikkan harga jual produk carica, dan pada musim kemarau diganti dengan produk makanan komoditas Kabupaten Wonosobo. Berdasarkan hasil penelitian, strategi yang diterapkan dalam kondisi ini adalah mendukung kebijakan yang agresif, yaitu industri kecil carica di Kabupaten Wonosobo dapat bersaing dengan produk olahan makanan jenis lainnya dari berbagai daerah dengan cara menjaga dan meningkatkan kualitas produk carica yang dihasilkan.

The purpose of this study to find out the profiles of carica industries in Wonosobo regency and to determine what is the development strategy can be used. The variables in this research belongs to human resources, capital, technology, and marketing. Data analysis method used is descriptive analysis method and SWOT analysis. Based on the results of this study showed that small industrial profiles carica in Wonosobo regency in 2014 there were 15 business units. There are several priority development strategies did, those are SO strategy to improve the quality of human resources to improve product quality of carica, utilizing the labor of the surrounding area to increase carica industry, and optimize strategic industrial location. WO strategy to prepare the inventory in the form of stock products carica, carica optimize product to meet consumer demand, and optimize the training of relevant agencies. ST strategies to improve the quality and characteristics of products carica, requires the role of government in terms of anticipating landslides in Dieng, and carica product innovation to improve consumer tastes. WT strategy to improve the managerial capacity of employers, raise the price of products carica, and in the dry season production carica replaced with other processed food products act. Based on the research results can be concluded, the strategy adopted in this condition is to support an aggressive policy.
PERTUMBUHAN EKONOMI DAN KETIMPANGAN PENDAPATAN ANTAR KABUPATEN DI KALIMANTAN TIMUR
Authors: YULIANI TUTIK
Published: September 2015

Penelitian ini bertujuan untuk mengetahui ketimpangan pembangunan dan  pendapatan  antar Kabupaten di Kalimantan Timur serta membuktikan apakah Hipotesis U terbalik berlaku di Propinsi Kalimantan Timur. Untuk mengetahui seberapa besar ketimpangan pendapatan digunakan Indeks Williamson dan Indeks Entropi Theil,.Berdasarkan indeks Wiliamson menunjukkan bahwa selama tahun 2010 sampai dengan 2012 terdapat ketimpangan pembanguan antar kabupaten di Kalimantan Timur sebesar 0.69 di tahun 2010 menjadi 0.72 di tahun 2012. Sedangkan dari hitungan Entropi Theil menunjukkan bahwa rata-rata selama tahun 2010 sampai dengan 2012 terdapat ketimpangan pendapatan sebesar 17.45. Setelah dilakukan analisis Kuznets menunjukkan bahwa di Kalimantan Timur selama tahun 2010 sampai dengan 2012 berlaku hukum Kuznets.

This study aims to find out the development and income inequality inter regency in East Kalimantan and prove whether the inverted U hypothesis applied in the East Kalimantan. To find out how much income inequality, the writer used Williamson and Theil's Entropy Index. Based on Williamson index, it indicates that there is income inequality inter regency in East Kalimantan during 2010 to 2012, at 0.69 in 2010 to 0.72 in 2012. Whereas Entropy Theil calculation shows that on average during 2010 to 2012, there was income inequality by 17.45. Meanwhile, Kuznets analysis shows that Kuznets law applied in East Kalimantan during 2010 to 2012.
LAMA TIDUR DAN AKUMULASI KELELAHAN KERJA (ACCUMULATED FATIGUE) PADA DOSEN
Authors: Yogisutanti Gurdani
Published: September 2015

Fatigue merupakan fenomena normal bagi setiap orang yang dapat dikurangi dengan istirahat maupun tidur. Tujuan penelitian untuk mengetahui hubungan lama waktu tidur dengan akumulasi kelelahan kerja pada dosen. Penelitian dilakukan pada tahun 2013 dengan desain cross sectional digunakan dalam penelitian terhadap 236 partisipan berasal dari 8 sekolah tinggi ilmu kesehatan swasta di Jawa Barat. Lama waktu tidur per hari diukur menggunakan kuesioner dan akumulasi kelelahan kerja diukur menggunakan instrumen self-diagnosis Check List for Assessment of Worker’s accumulated fatigue. Rerata waktu tidur adalah 6,23±1,1 jam per hari). Hasil uji statistik menggunakan Product Moment didapatkan lama waktu tidur berkorelasi negatif dengan gejala kelelahan subjektif (r=-0,132; p<0,05), kondisi kerja(r= -0,169; p<0,05) dan akumulasi kerja (r=-0,173; p<0,05). Semakin tinggi lama tidur, maka semakin rendah kelelahan kerja yang terjadi. Kurangnya waktu tidur dalam jangka waktu yang lama dapat berakibat pada kualitas hidup dosen dan dapat menyebabkan sakit. Untuk mengurangi akumulasi kelelahan kerja harus cukup waktu tidur dan beristirahat.

Fatigue is a normal phenomenon that can be reduced by rest and sleep. The aims of this study was to uncover the relationship between lecturers’ sleep duration and their job burnout. This research was conducted at 2013. The cross sectional design was applied to 236 participants from eight private Health Sciences School in West Java. Sleep durations were measured by a questionnaire and Self-diagnosis Check List for Assessment of Worker’s accumulated fatigue was used to measure lecturers’ job burnout. Results have shown that rates of the sleep duration in a day were around 6,23±1,1 hours. Product moment test has shown that the sleep duration had negative correlation with subjective fatigue (r=-0.132; p<0.05), working conditions (r=-0.169; p<0.05), and working accumulation (r=-0.173; p<0.05). The more sleep duration the lower job burnout. Long term sleepiness can be affected to  quality of live. Adequat sleep one of best way to deal with job burnout problems.
José de Alencar e a operação historiográfica: fronteiras e disputas entre história e literatura
Authors: Ramos Francisco Régis Lopes
Published: September 2015

Com base nas interrogações de Michel de Certeau sobre a “operação historiográfica”, este artigo examina os modos pelos quais José de Alencar procurou dar legitimidade ao seu modo de fazer do passado um objeto de conhecimento. Compreende-se, desse modo, que os romancistas assumiram, também, a tarefa de compreender o passado. E, além disso, ou subjacente a isso, passaram a rivalizar com a suposta circunscrição que os historiadores foram estabelecendo. Pretende-se abordar como a escrita de José de Alencar faz parte dessas tensões que ganharam mais força a partir do século XIX, transformando a história no “outro” da literatura, e a literatura no “outro” da história. Serão analisados certos confrontos entre história e literatura, levando-se em consideração que as lutas pelas fronteiras entre ambas fazem parte da própria legitimidade que a escrita da história vai constituindo para si mesma. Serão feitas algumas comparações entre a escrita de José de Alencar e a de outros romancistas, no sentido de mapear disputas e na perspectiva de perceber como a literatura foi se afirmando como o “outro” da “escrita da história”.
Uma crítica ao essencialismo identitário: a historiografia da mineiridade na primeira metade do século XX
Authors: Ramalho Walderez Simões Costa
Published: September 2015

A busca por uma identidade específica foi certamente um dos temas mais discutidos pela historiografia relativa a Minas Gerais. Este artigo pretende avaliar criticamente esse longo debate, focalizando os trabalhos de interpretação produzidos durante a primeira metade do século XX. Tais textos compreendiam a mineiridade como uma “essência”, objetiva, fixa, definitiva, comum a todos os mineiros, numa concepção identitária que não abria espaço para as mudanças e diferenças. Trata-se, aqui, de propor uma leitura “não-essencialista” dessas interpretações, compreendendo a identidade cultural como um processo em permanente construção. Esse exercício crítico deve auxiliar na discussão de possíveis caminhos para projetar um espaço público mais aberto, democrático e inclusivo em Minas Gerais.
História e integração regional: intelectuais, convênios e livros no Brasil e na Argentina nas primeiras décadas do século XX
Authors: Ribeiro da Silva Ana Paula Barcelos
Published: September 2015

O artigo analisa a reinterpretação da história desenvolvida no Brasil e na Argentina nas primeiras décadas do século XX, especialmente a partir da atuação do Instituto Histórico e Geográfico Brasileiro (IHGB) e da Junta de Historia y Numismática Americana. Objetivamos pensar os projetos de integração regional resultantes desses diálogos, suas características ideológicas, a reaproximação com as antigas metrópoles e o papel político-pragmático então assumido pela história. O trabalho relaciona os campos da história intelectual, da história das ideias políticas e da história da historiografia, embasando-se em ampla pesquisa realizada em arquivos brasileiros e argentinos, nos quais foram reunidos, entre outros materiais, documentos diplomáticos, correspondências e anais de congressos de história. Concluímos pela existência de uma revisão conjunta do olhar sobre o passado que possibilitava a ruptura com o isolamento historicamente presente nas relações entre o Brasil e os países vizinhos. Há aqui uma reconstrução identitária e a busca de alternativas pacíficas diante dos conflitos europeus.
O peso do cientificismo
Authors: Mollo Helena Miranda
Published: September 2015

Trata-se de resenha.
X-Switch: An Efficient , Multi-User, Multi-Language Web Application Server
Authors: Nyirenda Mayumbo , Suleman Hussein , Maunder Andrew , Van Rooyen Reinhardt
Published: September 2015

Web applications are usually installed on and accessed through a Web server. For security reasons, these Web servers generally provide very few privileges to Web applications, defaulting to executing them in the realm of a guest ac- count. In addition, performance often is a problem as Web applications may need to be reinitialised with each access. Various solutions have been designed to address these security and performance issues, mostly independently of one another, but most have been language or system-specic. The X-Switch system is proposed as an alternative Web application execution environment, with more secure user-based resource management, persistent application interpreters and support for arbitrary languages/interpreters. Thus it provides a general-purpose environment for developing and deploying Web applications. The X-Switch system's experimental results demonstrated that it can achieve a high level of performance. Further- more it was shown that X-Switch can provide functionality matching that of existing Web application servers but with the added benet of multi-user support. Finally the X-Switch system showed that it is feasible to completely separate the deployment platform from the application code, thus ensuring that the developer does not need to modify his/her code to make it compatible with the deployment platform.
The Research Foci of Computing Research in South Africa as Reflected by Publications in the South African Computer Journal
Authors: Kotze Paula , Van der Merwe Alta
Published: September 2015

The South African Computer Journal, better known as SACJ, has, for the last nineteen years, been one of the most pertinent

publications for the computing discipline within the South African milieu. In this paper we reflect on the topics of research

articles published in SACJ over its first 40 volumes of the journal using the ACM Computing Classification Scheme as basis. In

our analysis we divided the publications into three cycles of more or less six years in order to identify significant trends over the

history of the journal. We also used the same classification scheme to analyse the publication trends of various South African

tertiary education and research institutions.
Generic Network Location Service
Authors: Mwansa Laban , Janeček Jan
Published: September 2015

This work presents the Generic Network Location Service based on the Chord implementation utilizing data structures called distributed hash tables (DHT) or structured overlay networks, which are used to build scalable self-managing distributed systems. The provided algorithms guarantee resilience in the presence of dynamism: they guarantee consistent lookup results in the presence of nodes failing and leaving. Generic Network Location Service provides a Location Service system based on DHT technology, which is storing device location records in nodes within a Chord DHT.

Location records are consisting of network device identification keys as attributes, which are used to create replicas of additional location records through established Chord hashing mechanisms. Storing device location records, in places address-able (using the DHT lookup) by individual location record keys provides a simple way of implementing transla¬tion functions similar to well¬ known network services (e.g. ARP, DNS, ENUM).

The generic network location ser¬vice presented in the paper is not supposed to be a substitu¬tion of the existing translation techniques (e.g. ARP, DNS, ENUM), but it is considered as an overlay service that uses data available in existing systems and provides some translations currently unavailable.