bluuebunny/crossref_metadata_2025 huggingface dataset:
Self-Esteem Level of Public and Private Sector School Teachers: A Case Study of GGHS of District Swabi
Authors: Badshah Imran , Abrisheema Abrisheema
Published: April 2024

Self-esteem level of public and private sector school teachers: A case study of GGHS of district Swabi" was the title of the current research project. The study's goals were to ascertain public school teachers' levels of self-esteem. To investigate the level of self-esteem among teachers in private schools. The population of the study consisted of all the female secondary school teachers in the Khyber Pakhtunkhwa (Pakistan) district of Swabi. As a sample for the study, 100 female secondary school teachers from both public and private sector schools were chosen at random from the entire population. Data were gathered for the descriptive study using a self-created questionnaire. Data was gathered by means of in-person visits. After that, it was arranged, totalled, and examined. The examination of the gathered data was done using statistical tools, such as the percentage. Following a thorough survey of students in both public and private schools to gauge their degree of self-esteem, statistical analysis of the data revealed that those with higher self-esteem are more capable and competent and have access to more positive self-thoughts. To some extent, teachers in the public and private sectors of education have similar levels of self-esteem. But because of the stressful atmosphere and lack of service security in the private sector, teachers get a little bored.
Perceptions of Married Female Teachers Regarding the Impact of Job on their Family Life
Authors: Khalil Saima Zaman , Gul Nida
Published: April 2024

The impact of job on the family life of married female teachers was the title of the research. The purpose of this study was to explore the impact of the job on the family life of married female teachers and to describe the perceptions of family members regarding married female jobs. The entire primary school teacher constituted the population for the study. A sample of 100 married female teachers from 34 schools was randomly selected for this study. A quantitative research design was used for which a five-point Likert-type rating scale consisting of 12 items was designed. Data was collected from the married female primary school teachers. Percentage was used as a statistical tool for analysis of the collected data. Based on the findings, it was concluded that half of the female teachers feel that they face problems in getting permission to teach. The majority of female teachers feel that the distance of school from home also lowered their job satisfaction level. Most of the participants believed teaching jobs cause differences among their husbands. Most of the female teachers were that they had enough time for their husbands.
Research on Ideological and Political Education in the Curriculum of Basic Chemistry Courses in Medical Colleges Guided by Xi Jinping Thought on Culture
Authors: BIAN Weiwei , ZHAO Chunzhen , LI Xinxin , ZHANG Siqi , QI Mingying , WANG Xinying
Published: April 2024

At present, we are in a great transformation that has not been seen in a century in the world. In order to achieve the great rejuvenation of the Chinese nation, we must implement the fundamental task of education, moral education, and talent cultivation in university teaching. Guided by Xi Jinping Thought on Culture, we should promote the construction of ideological and political education in the curriculum comprehensively, integrating value shaping, knowledge transmission, and ability cultivation organically. This article takes the basic chemistry course in medical colleges as an example, and explores ideological and political education in the curriculum guided by Xi Jinping Thought on Culture from the perspectives of condensing traditional Chinese medicine ideological and political materials, stimulating cultural confidence, excavating Chinese scientists' ideological political materials, cultivating patriotism, introducing cutting-edge technology, and stimulating national pride, providing a foundation for cultivating
National first-class course: International Business Negotiation (including International Business Negotiation Simulation)
Authors: CHEN Zhong
Published: April 2024

In line with the educational positioning of Fujian Normal University to “cultivate high-level applied talents needed by society”, and the goal of the International Economics and Trade major to “cultivate applied talents with innovative consciousness, suited to global economic and trade demands”, this compulsory course for the major focuses on addressing students' lack of innovative consciousness and practical abilities. In implementing the course, emphasis is placed on integrating industry and education to jointly cultivate students, fostering innovative thinking and practical skills. The course aims to familiarize students with the basic theories, procedures, strategies, and legal knowledge of international business negotiations, and to master basic negotiation methods, skills, and the art of communication. Students are expected to develop abilities and qualities such as agile and clear thinking, the capability to express and convey information, keen insight, high-level forecasting and adaptability. The course actively implements the principles of “moral education and nurturing talents”, integrates ideological and political elements into the curriculum, and guides students to establish a correct view of negotiations. It aims to shape talents in international business negotiations who are conscious of the rule of law, possess social responsibility, team spirit, patriotism, and are suited to the demands of an open economic development. This paper discusses seven aspects: basic course information, teaching professors (teaching team), course objectives, course construction and application, course features and innovations, course construction plan, and a list of supplementary materials. It elaborately presents the core content of the application in strict accordance with the requirements of the second batch of national first-class undergraduate course application (offline course), offering a reference for the application of the third batch of national first-class undergraduate courses.
Tea culture carries the message: Analysis on creative product design and promotion based on Guangdong tea culture
Authors: LIANG Siyi , LAI Yurong , LIANG Xujun , LIN Yingxia , CHEN Mengna
Published: April 2024

As a precious gem of Chinese traditional culture, tea culture carries thousands of years of history and rich cultural connotations, but also faces challenges in international dissemination. This study takes the student innovation and entrepreneurship project Tea culture carries the message from Guangdong University of Education as a case to explore the inheritance and innovation of Chinese tea culture. By analyzing the practice of the this project, this paper focuses on studying the strategies and implementation process of promoting creative products, aiming to provide experience and insights for the dissemination of Chinese tea culture in contemporary society with an academic perspective.
System of Alternative Measures and Misdemeanour Sanctions in Juvenile Misdemeanour Legislation in Bosnia and Herzegovina and Countries of the Region
Authors: Mitrović Ljubinko , Baričanin Jelena
Published: April 2024

Misdemeanour sanctions in Bosnia and Herzegovina represent state, coercive measures of a repressive-preventive nature, by which the offenders, under the conditions stipulated in offense regulations, are limited or deprived of certain rights or freedoms, based on the decision of the competent court, i.e. the authorized body, made in a lawfully implemented misdemeanour procedure. On the other hand, almost all modern penal, criminal and misdemeanour legislation provides for one or more parapenal, alternative measures, i.e. penal sanctions that are carried out under the auspices of the social community, such as compensation for property damage to the injured party, mediation or settlement of the perpetrator and the injured party, financial settlement, bail, subjecting the offender to treatment of a criminal offense or misdemeanour or sending him to training, i.e. attending training, police supervision of the offender, banning the offender of a criminal or misdemeanour from accessing a certain place or person, community service by the offender, work for the benefit of the community, monitory fines (which in a series of positive criminal legislation appears as a substitute for prison sentences as the most severe punishment), confiscation of a driver’s license, or educational recommendations, or educational orders, etc. In this paper, the authors deal with the juvenile misdemeanour legislation, primarily that of Bosnia and Herzegovina, and then with the juvenile misdemeanour legislation of individual countries of the region, and in the context of alternative measures and misdemeanour sanctions prescribed in these legislations against juvenile offenders.
Reform of Criminal Procedure Legislation in Bosnia and Herzegovina - Expectations, Reality and Perspectives
Authors: Simović Marina , Karović Sadmir
Published: April 2024

In this paper, the attention is focused on the efficiency of the criminal procedure, with a special focus on the efficiency of the criminal process entities in terms of elucidating and solving a specific criminal matter. In connection with the above, the authors recognized and identified the key procedural problems related to the timely, efficient and legal detection and proof of the criminal act and guilt. Given that a significant period of time has passed since the last general reform of the criminal procedure legislation, sufficient for a critical analysis, a critical review of all phases of the criminal procedure was carried out with the intention of actualizing and problematizing certain legal solutions of a procedural nature (detective activity, investigation concept, standards evidence, evidentiary role of the prosecutor, drawing up/filing of the indictment, complexity of discovery and proof, etc.) on which the efficient and legal conduct and finalization of criminal proceedings directly depend. Also, modern forms of criminality, especially specific forms of organized crime, demand from the legislator the adequacy of the legal norm in terms of achieving a legitimate legal goal related to the effective and energetic fight against crime as a complex social phenomenon and achieving adequate results of criminal justice.
Računarstvo u oblaku za računarom podržano konstruisanje
Authors: Lemeš Samir
Published: April 2024

Računarstvo u oblaku je rastući segment informacionih tehnologija i svakodnevno nalazi nova područja primjene. Jedno od područja koje se dugo opiralo ovoj tehnologiji je CAD (računarom podržano konstruisanje), jer je podrazumijevalo potrebu za prenosom veće količine grafičkih podataka. Posljednjih nekoliko godina svi vodeći proizvođači CAD softvera u paletu proizvoda uvrstili su i rješenja zasnovana na računarstvu u oblaku. Počelo se s konceptom IaaS (infrastruktura kao usluga) omogućavanjem pristupa zajedničkim repozitorijima za CAD datoteke u oblaku, nakon čega se prešlo na PaaS koncept (platforma kao usluga) kroz kolaborativni rad i vezu sa PDM/PLM sistemima. Moderni koncept podrazumijeva SaaS (softver kao usluga), odnosno pokretanje aplikacija, obrada i pohranjivanje podataka kroz internet browser ili kroz namjensku mobilnu aplikaciju. U ovom radu dat je osvrt na aktuelna SaaS rješenja vodećih proizvođača CAD softvera.
Poboljšanje procesa montaže primjenom Lean alata
Authors: Guzina G. , Gojković R. , Moljević S. , Jokanović Đajić M.
Published: April 2024

Montaža proizvoda kao završni proizvodni proces je jedan od najvažnijih dijelova, njen kvalitet ima veliki uticaj na kvalitet proizvoda. Cilj upotrebe Lean alata je povećanje efektivnosti, funkcionalnosti, generalno poboljšanje organizacije na nivou cijelog preduzeća, kao i eliminisanje nepotrebnih aktivnosti tj. gubitaka u procesu proizvodnje. Dobro organizovan i čist pogon procesa montaže se dobija upotrebom Lean alata što doprinosi poboljšanju svih prethodno nabrojanih kvaliteta, a samim tim i procesa proizvodnje. Primjena Lean alata u procesu montaže omogućavaju povećanje kvaliteta montaže, povećanje efikasnost i smanjenje troškova procesa proizvodnje.
Uticaj parametara sinteze polaznog praha 50.0 wt% Fe, 47.0 wt% BaTiO3, 33.0 wt% TiO2 na magnetna svojstva sinterovanih uzoraka
Authors: Vuković Z. , Kosić O. , Luković M. , Maričić A.
Published: April 2024

Polazni prah 50.0 wt% Fe, 47.0 wt% BaTiO3, 3.0 wt% TiO2 aktiviran je u planetarnom mlinu u intervalu od 0 do 220 min sa koracima od 20 min. XRD i SEM analizom aktiviranih prahova pokazano je da se sa povećanjem vremena aktivacije menja hemijski sastav praha. Istovremeno dimenzije čestica praha se smanjuju, a raste gustina defekata i mehaničkih mikronaprezanja u prahu. Jedan uzorak polaznog praha aktiviran je 10h, a potom kalcinisan na 1000°C u toku 4h. Kalcinisan prah presovan je u primenjenom magnetnom polju indukcije B = 0,85T. Pokazano je da uzorci presovani u magnetnom polju, nakon sinterovanja imaju povećanu magnetizaciju za oko 10% u odnosu na sinterovane uzorke koji nisu presovani u magnetnom polju. Presovanjem u magnetnom polju dobijen je polikristalni sinterovani orijentisani (anizotropni) uzorak.
Modelling and optimisation of power consumption and productivity in milling of thin-walled parts
Authors: Sredanovic B. , Tesic S. , Simic V. , Cica D. , Borojevic S.
Published: April 2024

A high percentage of mechanical parts in the metalworking industry (automotive, medical, energetic sector, and etc.), refers to thin-walled structures with optimized shapes and dimension, which produce on high or semi batch production principle. Production processes management, in mentioned industry and production systems, requires the development of appropriate information technologies based automatic systems. Planning and control systems are based on computer-aided technologies. Basis of this system are mathematical-logical models commonly, which is quantitatively link between input process parameters and process performance indicators (output parameters). In this study, modelling of total power consumption and process productivity was performed. Total power consumption and the process productivity were modelled, as very important output indicators in efficient and sustainable production. The modelling is based on the experimental analysis of the machining process during machining of thin-walled parts made of C45E (AISI 1045) carbon steel. Modelling was performed using the least squares method, with the use of ANOVA statistical analysis for the purpose of defining the input factors significance. Depth of cut, milling width and feed per tooth were used as input cutting parameters. Input cutting parameters combined experimental analysed according to Taguchi experimental plan. Based on developed adequate and sufficiently accurate mathematical models, optimization procedure was performed. The goal of optimisation was to minimize the power consumption and maximise productivity.
Hidroenergetski potencijal sliva rijeke Sutjeske
Authors: Kašiković M. , Karadžić U.
Published: April 2024

Energija predstavlja veoma važan faktor razvoja. Potrebe za električnom energijom su u stalnom porastu. Veliki dio proizvedene energije u svijetu dolazi iz neobnovljivih izvora energije, uglavnom fosilnih goriva za koje se smatra da su glavni razlog za globalno zagrijavanje. Dobro isplanirana i efikasna upotrreba svih dostupnih energetskih izvora , a posebno obnovljivih izvora, je neophodna da bi se ispunili zahjevi energetske potražnje. Hidroenergija predstavlja jedan od najvažnijih obnovljivih izvora energije. Značajan dio hidroenergetskoh potencijala je već iskorištem izgradnjom i radom velikih hidroelektrana, dok su manji vodotoci i dalje velikim dijelom neiskorišteni. Male hidroelektrane imaju neznatan negativan uticaj na životnu sredinu , za razliku od konvencionalnih energetskih postrojenja. U radu je predstavljen hidropotencijal sliva rijeke Sutjeske, tj navedene su mogućnosti izgradnje malih ehidroelektrana. Rijeka Sutjeska velikim dijelom prolazi kroz istoimeni nacionalni park. Na rijeci Sutjesci i njenim pritokama Hrčavki, Jabušnici, Klobučarici i Sušici (Suhi) pklanirana je izgradnja 13 malih hidroelektrana sa različitm tehničkim riješenjima. Na osnovu toga može se zaključiti da ovaj sliv ima značajan tehnički iskoristiv hidropotencijal koji je za sada neiskorišten.
ИСТОРИЈСКО-ПОЛИТИЧКИ КОНТЕКСТ МАКЕДОНСКОГ ЦРКВЕНОГ ПИТАЊА
Authors: Ернаут Милош
Published: April 2024

Аутор у раду на хронолошки начин представља генезу ма- кедонског црквеног питања, које је било актуелно више од пола вијека, док узроци овог црквеног спора сежу у другу половину 19. вијека, када, након пропасти Отоманског царства, долази до формирања националних држава. Mакедонска православна црква прогласила је аутономност 1958. године, која је касније призната од стране Српске православне цркве, а аутокефалност 1967. године, што је изазвало црквени раскол који је трајао 55 година, све до 2022. године, када је Македонској православној цркви признат аутокефални статус од стране Српске православне цркве. Ово наизглед црквено питање било је у великој мјери подстакнуто од стране тадашњих југословенских савезних и републичких власти, а изненадно окончање овог међуцрквеног спора такође је разријешено под утицајем геополитичких процеса, који су се одразили, између осталог, и на односе међу православним црквама.
ПРВА КЊИГА О УСТАНКУ У ИСТОЧНОЈ ХЕРЦЕГОВИНИ 1875–1878. ГОДИНЕ
Authors: Милошевић Петар
Published: April 2024

Задужбина „Кнез Мирослав Хумски“ почетком године објавила је своју десету, јубиларну књигу под називом „Устанак у Источној Херцегови- ни 1875–1878. Узроци, ток и посљедице“ аутора младог историчара Лазара Радана. Објављена књига је формата А5 и има скоро 350 страница.
ПЕТРОВАЧКЕ ЦЕСТЕ
Authors: Мандић Вук
Published: April 2024

Бошко М. Бранковић је ванредни професор на Студијском програму историје Филозофског факултета Универзитета у Бањој Луци. Неопходно је поменути да је професор Бранковић 2011. године одбранио магистарски рад под називом ”Петровац од 1700. до 1918. године”. Ово дјело касније је објављено као монографија, али и пређашњи радови о завичајној про- шлости, најбоље свједоче како о научним интересовањима, тако и о мје- родавности аутора.
ДЕЈАН МИКАВИЦА (1964-2022)
Authors: Милошевић Боривоје
Published: April 2024

У Новом Саду је 2. новембра 2022. у 58. години живота изненада пре- минуо историчар Дејан Микавица, редовни професор Филозофског факул- тета.
ДУШАН БЕРИЋ (1948-2023)
Authors: Милошевић Боривоје
Published: April 2024

У Новом Саду је 29. априла 2023. године преминуо Душан Берић, угледни српски историчар и члан АНУРС-а. Рођен је у Трнову код Мркоњић Града, 7. јануара 1948. године.
MORPHOLOGICAL CHARACTERISTICS AND CONDITION OF BLEAK ALBURNUS ALBURNUS (TELEOSTEI; CYPRINIDAE) FROM THE BOSNA RIVER
Authors: Golub Dragojla , Bukva Marija , Dekić Radoslav
Published: April 2024

This paper presents data about morphological (morphometric and meristic) characteristics, Fulton’s condition factor (K) and length-weight relationship of bleak (Alburnus alburnus) from the Bosna River. The fish sampling was performed during December 2016 and the total of 101 bleak individuals was caught. On that occasion, 14 morphometric characteristics, body mass and six meristic characteristics were analyzed. As observed on the basis of morphometric characteristics, the bleak population from the Bosna River was dominated by smaller individuals which could be explained by the period of sampling (winter) and part of river where sampling was performed (coastal shallow part). The obtained values of the Fulton’s condition factor indicated that the bleak population from the Bosna River was in a relatively poor condition (0.61), while the parameter b indicated a negative allometric growth (b=2.8865) and the fish was characterized by a more intense length growth when compared to the mass growth. The obtained results regarding meristic parameters were mainly similar to the well-known data from the great body of work on the topic.
POSTSOCIJALISTIČKA URBANA TRANSFORMACIJA BANJA LUKE
Authors: Mandić Mira
Published: April 2024

Contemporary urban concept of Banja Luka at the begginig of the 21st century is established in terms of the post-socialist society or so-called transition. Urban space becomes the ground of interweaving different interests and reflects the overall social conditions. New social relations shift the approach toward urban development planning (economic, social, infrastructural, spatial), which is at the discrepancy between the city population needs and interests of the individual social groups. The newly established physical structures change the urban concept in the long-term period and actualize the problem of efficient and equitable managment of urban space and the establishment of sustainable urban structures in the function of overall development. The paper focuses on various aspects of modern transformation of urban space of Banja Luka with a critical review of the established practice and urban structures and points out the problems of socio-economic development and spatial-functional organization resulting from elemental development and conflict of different interests in the post-Socialist society.
POSTSOCIJALISTIČKA URBANA TRANSFORMACIJA BANJA LUKE
Authors: Mandić Mira
Published: April 2024

Savremeni urbani koncept Banje Luke početkom 21. vijeka uspostavlјa se u uslovima postsocijalističkog društva. tzv. tranziciji. Urbani prostor postaje poligon preplitanja različitih interesa te odražava ukupne društvene prilike. Novi društveni odnosi mijenjaju pristup planiranju urbanog razvoja (ekonomskog, socijalnog, infrastrukturnog, prostornog). U planiranju prostora grada sukoblјavaju se interesi pojedinih društvenih grupa. Novouspostavlјene fizičke strukture dugoročno mijenjaju urbani koncept i aktuelizuju problem efikasnog i pravičnog upravlјanja urbanim prostorom i uspostavlјanja održivih urbanih struktura u funkciji ukupnog razvoja. Rad aktuelizira različite aspekte savremene transformacije urbanog prostora Banje Luke s kritičkim osvrtom na uspostavlјenu praksu i urbane strukture, te ukazuje na probleme socioekonomskog razvoja i prostorno-funkcionalne organizacije proizašle iz stihijskog razvoja i sukoba različitih interesa u postsocijalističkom društvu.
State of Charge Estimation for Lithium Battery Based on Fractional Order Square Root Cubature Kalman Filter and Adaptive Multi-innovation Unscented Kalman Filter
Authors: Wei Ying
Published: April 2024

Accurate state of charge (SOC) estimation of batteries is of great significance for electric vehicles. A SOC estimation method based on a fractional order square root cubature Kalman filter (FOSRCKF) and an adaptive multi-innovation unscented Kalman filter (AMIUKF) is proposed. The battery is modelled using fractional order calculus theory and the model parameters are identified by adaptive genetic algorithm. The FOSRCKF estimates the battery SOC, while the AMIUKF online updates the internal resistance in the model, and there exchanges information between two filters. The experimental results under the Urban Dynamometer Driving Schedule (UDDS) and the US06 Highway Driving Schedule show that the proposed method has lower SOC estimation error and lower terminal prediction error compared with the traditional SRCKF method based on integer order models, which demonstrates the effectiveness, accuracy and robustness of the proposed method.
Assessment of Radon Potential along Local Fault System in Sofia, Bulgaria (at Specific Test Site)
Authors: Antonov Dimitar , Ivanova Kremena , Benderev Aleksey , Djunakova Desislava , Yordanov Todor , Kolev Sava , Kunovska Bistra
Published: April 2024

Environmental spread of radon gas (222Rn) has been intensively investigated in the last few years due to its harmful effects on human health. A concept of radon index is used to characterize the geogenic radon potential of the terrain, as the latter gives the probability of the presence of radon gas concentration in a building, the genesis of which is directly related to the influence of the earth's surface. One of the approaches for quantifying the radon index is based on a multivariate cross-tabulation, which includes two parameters – radon  concentration in soil gas and gas permeability of the earth layer (at 80 cm). The geology of the specific site (approx. 350 m2) is characterized by the Pliocene clayey-sandy Formation, covered with Quaternary sediments. From tectonic point of view, the site as a part of Sofia Graben, has being subject of events related mainly with the Late Alpine deformations heading to very complex structures and fault systems. In situ measurements performed in the summer of 2023 at ten distinct points at the surface and 11 distinct points at two meters in depth from the surface vary as follows: from 44.2 to 189.0 kBq/m3 (radon soil gas), from 2.0E-11 to 1.8E-13 m2 (soil gas permeability), and from 0.10 to 0.17 µSv/h (gamma dose rate). Based on that, the radon index of the site is determined from “medium” to “high”, with a predominance of the latter. One of the reasons for the high radon potential is the presence of sub-faults connected with the major Sofia fault system and their influence on the radon concentration. Therefore, in future investigations of the radon index, a very detailed survey of the site's geology is needed in the territory with appearing fault systems. In addition, based on the determination of the radon index, the forthcoming construction activities in such areas will be advised to use preventive measures during the construction of the new building to avoid future radon gas influxes on the premises.
Management and Business Model Risk Profile in Security Systems Development
Authors: Panevski Valeri
Published: April 2024

The business model applied in the development of security systems by scientific organizations, independently or in terms of key partnerships with higher education institutions and business organizations structured through competence centres, are part of their strategic assets. But in managing this business model, both planned and unforeseeable risks may arise, which determines the need to develop a business model risk framework.
The author's experience in structuring a business model risk framework for the development of security systems by scientific organizations is the basis of the present publication.
Morphometric Changes of the Myenteric Plexus in the Colon of the Mice-D-Galactose Ageing Model
Authors: Genov Nikolay , Tomov Nikola , Dimitrov Nikolay , Kirov Todor , Petrov Lubomir , Tsvetanova Elina , Georgieva Almira , Alexandrova Albena , Lazarov Nikolai , Atanasova Dimitrinka
Published: April 2024

Ageing-related diseases are paramount for understanding the socioeconomic impact of the postmodern society. Neuronal degeneration is a known phenomenon in ageing. The D-galactose model of accelerated ageing is widely used in age-associated neuronal cell death because of the oxidative stress it induces, which correlates to reduced cognitive performance and robustly detectable neuronal shrinkage in the CNS. This study aims at demonstrating the morphological changes of neurons of the myenteric plexus in mice treated with D-galactose. D-galactose was given orally with drinking water, resulting in an average dose of 500 mg/kg daily for six weeks. In the D-galactose accelerated ageing model, a significant size reduction of the neuronal perikarya of the myenteric plexus was observed all along the large intestine. The average soma area at the caecum in the control group was 305 µm2, which was reduced by almost 20% in the ageing model. In contrast, at the level of the proximal colon in the D-galactose ageing model, the average area of the neuronal soma was 280 µm2, a reduction of 30%. The most significant reduction has been observed at the level of the distal colon, where the neuronal soma was reduced by 40%. There is a significant reduction of the area of the neuronal bodies in the myenteric plexus among different parts of the mice's large intestine in the accelerated ageing model. It can be inferred that D-galactose-induced morphological changes in the myenteric plexus may be related to the increased gastrointestinal motility dysfunction with ageing.
Anti-cancer Effect of Neocuproine on Oxidative Stress and Inflammatory Levels Induced by Neuroblastoma Cancer Cells
Authors: Demirdogen Filiz , Yesilyurt Fatma , Budak Aysenur , Akcay Guven , Hacimuftuoglu Ahmet
Published: April 2024

Neocuproine is a free radical scavenger. Neuroblastoma cancer is seen mostly in children. It accounts for approximately 15% of all pediatric cancer deaths. Treatments against SH-SY5Y may be ineffective due to the development of drug resistance, resulting in poor survival in high-risk patients. The goal of this study was to find out how the anti-cancer concentration of Neocuproine affected the levels of oxidants, antioxidants, and cytokines in the SH-SY5Y cell line. Five different concentrations of Neocuproine (12.5, 25, 50, 100, and 200 µM) were applied to the cell line for 24 h. MTT cytotoxicity tests, total oxidant status and total antioxidant capacity tests, and anti-inflammatory cytokine tests were used to look at the uses of Neocuproine. In our results, 100 µM Neocuproine application reduced cancer cell viability up to 69.76%. In addition, it was determined that 100 µM Neocuproine reduced oxidant activity, increased antioxidant capacity, and regulated anti-inflammatory cytokine levels in neuroblastoma cells, consistent with the cytotoxicity test. As a result, it was concluded that Neocuproine has an anti-cancer effect on the SH-SY5Y cell line.
Immune Responses in Children Infected with Streptoccocus A during the Spring 2023 Epidemic in Bulgaria
Authors: Altankova Iskra , Kukov Alexander , Petkov Simeon , Stancheva Assia , Ivanova Izabela , Georgieva Boriana , Keuleyan Emma , Uzunova Yordanka
Published: April 2024

Streptococcus pyogenes, Group A Streptococcus (GAS), is the most common cause of bacterial tonsillitis, scarlet fever, impetigo, etc. in children and adults. Innate and adaptive host immune responses are fundamental for human defence against GAS, but are also important to the clinical manifestations of the infection.
Our aim was to study the humoral and cellular immune responses in children infected with GAS and diagnosed with tonsillitis in the Clinic of Pediatrics in University Hospital “Lozenets”.
The study included 22 infected children and 20 healthy controls. The following immune parameters were investigated: i) Humoral immune response – total serum IgG, IgM, IgA; C3, C4 – complement components, as well as the serum cytokines IFNγ, IL-6, IL-1β, TNFα, IL-17A, IL-10. ii) Cellular immune subsets were tested by immunophenotyping of total T cells, B cells, NK cells, T helper and T cytotoxic subsets.
In this cross-sectional study we found a significant increase in the complement components C3 and C4, increased production of serum IFNγ, IL-6 and IL-10 and decreased levels of IL-17A in infected children with tonsillitis, compared to healthy controls. The cellular immune parameters in infected children showed lymphopenia, reduced total T lymphocytes and T-helper subpopulation, compared to healthy controls.
We assumed that these imbalanced immune responses, found in infected children, are connected with GAS infection and deserved more detailed investigation.
Impact of Endometriotic Cyst Position on Infertility
Authors: Magunska Nadya , Yunakova Maria , Bochev Ivan , Slavov Sergei , Kostov Ivan
Published: April 2024

Endometriosis is one of the most common benign gynecologic disorders affecting reproductive health. There are many theories regarding how endometriosis affects fertility, but the exact mechanisms are still uncertain.
We evaluated 100 patients with unilateral ovarian endometriosis and infertility who underwent ovarian cystectomy. The women had at least one patent tube after surgery and were observed for spontaneous pregnancy for up to one year. Patients were divided into two groups according to the endometrioma position. The first group included 67 women with an endometriotic cyst in the left ovary, and the second group included 33 with an endometrioma in the right ovary. Groups were similar according to age, type of infertility, BMI, and size of the endometrioma.
The number of patients was significantly higher in the first group. Spontaneous pregnancy after cystectomy occurred in 28.4% of the patients with an endometrioma in left ovary, and in 9.1% with a right endometriotic cyst.
The better results regarding spontaneous conception with a left-sided endometrioma in our study are most likely related to the permeability of the fallopian tubes and adhesions in the Douglas pouch as a result of endometriosis. Further investigations are necessary to assess the influence of the laterality of endometriosis on infertility.
Nerve Magnified Regeneration by Distal Nerve Transfer in High Ulnar Nerve Injury
Authors: Angelov Kalin , Marcheva Iliyana , Apostolu Elena , Simeonov Nikola , Kateva Margarita
Published: April 2024

The concept of nerve-magnified regeneration, part of which is end-to-side nerve transfer, provides a theoretical basis for the treatment of high ulnar nerve injuries. High injury to the ulnar nerve causes severe consequences, such as loss of sensation, loss of movement and “claw hand” deformity, affecting the fine motor skills of the hand. A method of nerve-magnified regeneration – distal nerve transfer – interosseous anterior (median nerve) to the deep ulnar nerve at the wrist level is presented, used in 20 patients (2 to 66 years of age) with an average follow-up period of 3 years (10 months to 5 years). This is a microsurgical method for rapid re-innervation of the most distal hand muscles in proximal neurotmesis of ulnar nerve.
Determination of Main Properties and Fertility Capacity of Soils under Hazelnut Cultivation in Azerbaijan
Authors: Mammadova Gunay , Gahramanova Aida , Bunyatova Lala , Babayeva Tunzala , Huseynova Lala
Published: April 2024

The main priority of our research is the proper development of agriculture, optimal use and protection of soil resources. Hazelnut is an important crop in the study area, a benchmark indicator of the ecological condition of the soil. The purpose of the research is to determine the indicators of the main diagnostic edifiers in gray-brown soils under hazelnuts (Corylus avellana L.) in different seasons in 2022–2023. Mature trees grown without irrigation and fertilizers can produce 15–20 kg/tree, and with intensive care the yield can reach 40 kg/tree. As a result of our research into determining the main levels of productivity of agricultural soils in the southern region of the Greater Caucasus, it was found that 72.0% of agricultural lands are loamy soils, and their pH values range between 4.8 and 7.2, most soils have average organic matter content, 50.15{\%} less calcareous and all soils are salt-free. Soil quality scale rating is 87 points in soils under hazelnuts. It has been established that the soils are 40% slightly acidic, 25% neutral, 70% less calcareous, loamy in texture and sufficient in organic matter content. The soils of the walnut orchard were 49{\%} and 26{\%} slightly and moderately acidic, 76% were less calcareous, and 9% were deficient in organic matter.
Reproductive Traits in Two Alpine Endemic Species of Campanulaceae
Authors: Yankova-Tsvetkova Elina , Vladimirov Vladimir
Published: April 2024

Alpine plants are well adapted to environments with extreme conditions – low temperatures, a short growing season, increased air humidity and precipitation, and are therefore of particular interest for research. The aim of the present study is to reveal the main reproductive characteristics of two endemic species of the family Campanulaceae, namely Campanula orbelica (Balkan endemic) and Jasione bulgarica (Bulgarian endemic). The main features of the reproductive biology (embryological features, type of reproduction) were established based on the study of micro- and macrosporogenesis and the development of male and female gametophytes. The established features of the reproductive structures and processes characterized C. orbelica and J. bulgarica as sexually reproducing species. Despite the extreme conditions of existence, the studied species presented normal generative progresses leading to the formation of pollen and embryo, which ensures their successful reproduction, populations stability and their distribution in the subalpine environment.
In addition, the genome size of C. orbelica was studied by flow cytometry. The estimated genome size varied in the range 1C = 1.34–1.38 pg. No deviation in the ploidy level was found in 22 specimens fresh leaves of which were collected from different parts of the Rila and Pirin Mts.
Pectin methylesterase activity is required for RALF1 peptide signalling output
Authors: Rößling Ann-Kathrin , Dünser Kai , Liu Chenlu , Lauw Susan , Rodriguez-Franco Marta , Kalmbach Lothar , Barbez Elke , Kleine-Vehn Jürgen
Published: April 2024

The extracellular matrix plays an integrative role in cellular responses in plants, but its contribution to the signalling of extracellular ligands largely remains to be explored. RAPID ALKALINIZATION FACTORs (RALFs) are extracellular peptide hormones that play pivotal roles in various physiological processes. Here, we address a crucial connection between the demethylation machinery of the cell wall component pectin and RALF1 activity. Pectin is a polysaccharide, contributing to the structural integrity of the cell wall. Our data illustrate that the pharmacological and genetic interference with PECTIN METHYL ESTERASEs (PMEs) abolishes RALF1-induced root growth repression. Our data suggest that positively charged RALF1 peptides bind negatively charged, demethylated pectin with high avidity. We illustrate that the RALF1 association with demethylated pectin is required for its FERONIA-dependent perception, contributing to the control of the extracellular matrix and the regulation of plasma membrane dynamics. Notably, this mode of action is independent of the FER-dependent extracellular matrix sensing mechanism provided by FER interaction with the Leucine-Rich Repeat Extensin (LRX) proteins. We propose that the methylation status of pectin acts as a conceptualizing signalling scaffold for RALF peptides, linking extracellular matrix dynamics to peptide hormone-mediated responses.
Humour scandals in the Finnish political public sphere in 1990–2020
Authors: Herkman Juha , Koivukoski Joonas
Published: April 2024

Humour is a part of contemporary mediated political struggles. At times, humour itself becomes politicised, turning into public controversies or humour scandals. This study explores how humour scandals have become intertwined with the Finnish political public sphere during the last three decades. Quantitative mapping, based on journalistic articles retrieved from two nationwide media, reveals that between 1990 and 2020, 26 national humour scandals in Finland were reported in the national public sphere for at least five days. The number of scandals increased exponentially, from just two such scandals in the 1990s to 15 in the 2010s. Our qualitative analysis of three humour scandals from different decades demonstrates how humour controversies relate to the changes in political and media environments and moral order. While in the 1990s and early 2000s humour scandals often dealt with clashes between popular TV satires and leading politicians, from the 2010s onwards the topics of humour scandals diversified, including issues related to political campaigning, artistic performances, and racism.
'Laughing at us'
Authors: Basu Sammy
Published: April 2024

That Donald J. Trump won the US Presidential Election of 2016 defied the expectations of almost all seasoned observers of the US political system. Scholarly explanations stress structural factors that produced a substantial cohort of identity-vulnerable voters in tandem with Trump’s personal populist appeal. Trump benefitted from his political outsider status, celebrity familiarity, heteronormative masculinity, and unconventional rhetorical style including humour, all of which were amplified (and also mocked) by extensive mainstream news media coverage. Trump’s distinctive political use of the social media micro-blogging platform Twitter (now known as X) in engaging those cohorts has also been emphasized. The research presented here sits at the confluence of prior scholarly work on structural causes of identity vulnerability, on contestation involving humour, and on the enhanced political usage of Twitter. It examines the historical record of Trump’s tweets and re-tweets to see if and how the demarcation of his ‘humour brand’ affectively engaged his substantial Twitter followers and may thereby have contributed to his electoral success in 2016.
From mocking pastors to roasting politicians
Authors: Nieuwenhuis Ivo
Published: April 2024

In this article, I argue that humour scandals are less a product of the changing media landscape of the last thirty years than recent studies seem to suggest. Instead, I point to the structural continuities that can be observed in Dutch humour scandals over the past seventy years. Although stemming from various sociocultural and media contexts, these scandals roughly follow the same ‘script’. I also show that humour scandals are not just mediated events, but markers of cultural conflict as well. Behind every scandal, a substantial moral, cultural, and often also social divide can be recognised, and the study of humour scandals can be used to better understand such divides. I substantiate both of these claims through a qualitative, contextual analysis of two Dutch humour scandals: the mocking of Catholic pastors by comedian Wim Sonneveld in a TV performance from 1963, and the roast of far-right politician Thierry Baudet by comedian Martijn Koning in a popular late night talk show from Spring 2021.
Genome-wide identification and analysis of ascorbate peroxidase (APX) gene family in hemp (Cannabis sativa L.) under various abiotic stresses
Authors: Liang Zixiao , Xu Hongguo , Qi Hongying , Fei Yiying , Cui Jiaying
Published: April 2024

Ascorbate peroxidase (APX) plays a critical role in molecular mechanisms such as plant development and defense against abiotic stresses. As an important economic crop, hemp (Cannabis sativa L.) is vulnerable to adverse environmental conditions, such as drought, cold, salt, and oxidative stress, which lead to a decline in yield and quality. Although APX genes have been characterized in a variety of plants, members of the APX gene family in hemp have not been completely identified. In this study, we (1) identified eight members of the CsAPX gene family in hemp and mapped their locations on the chromosomes using bioinformatics analysis; (2) examined the physicochemical characteristics of the proteins encoded by these CsAPX gene family members; (3) investigated their intraspecific collinearity, gene structure, conserved domains, conserved motifs, and cis-acting elements; (4) constructed a phylogenetic tree and analyzed interspecific collinearity; and (5) ascertained expression differences in leaf tissue subjected to cold, drought, salt, and oxidative stresses using quantitative real-time-PCR (qRT-PCR). Under all four stresses, CsAPX6, CsAPX7, and CsAPX8 consistently exhibited significant upregulation, whereas CsAPX2 displayed notably higher expression levels under drought stress than under the other stresses. Taken together, the results of this study provide basic genomic information on the expression of the APX gene family and pave the way for studying the role of APX genes in abiotic stress.
The status and influencing factors of abnormal fetal pregnancy outcomes in 265 cases in China: a retrospective study
Authors: Ruan Jing , Zhong Xuemei , Mai Jiaxuan , Liu Cuifen , Ding Huiyang
Published: April 2024

Background

With the advancement of prenatal diagnosis technology, the detection rate of fetal abnormalities continues to increase, imposing a significant burden on both society and families. A retrospective analysis of essential information about pregnant women, such as their pregnancy history and delivery details, is crucial for understanding the primary factors that influence pregnancy outcomes in women with fetal abnormalities. This analysis is of great significance for improving the level of pregnancy management and outcomes in pregnant women with fetal abnormalities.

Objective

To retrospectively analyze the pregnancy outcomes of women with fetal abnormalities and explore the factors that influence these outcomes.

Methods

Pregnant women’s pregnancy outcomes were collected from the medical information system and through telephone follow-ups. The chi-square test and logistic regression were used to analyze the factors influencing pregnancy outcomes.

Results

Among 265 pregnant women diagnosed with fetal abnormalities, 190 chose to continue the pregnancy, while 75 chose to terminate it. Pregnant women with multiple fetal abnormalities (OR = 3.774, 95% CI [1.640–8.683]) were more likely to choose termination of pregnancy (TOP), and pregnant women who were advised to terminate their pregnancy or make a careful choice were more likely to terminate the pregnancy (OR = 41.113, 95% CI [11.028–153.267]).

Conclusion

The number of organs involved in fetal abnormalities and treatment recommendations were identified as the primary factors influencing pregnancy outcomes. Improving awareness of maternal health care during pregnancy, early pregnancy screening technology, and a multidisciplinary diagnosis and treatment approach are of great significance in assisting pregnant women in making informed decisions and improving fetal prognosis.
Acknowledgement to reviewers and guest editors of ECOSISTEMAS in the year 2023
Authors: Hernández Mateo Laura , Jiménez-Eguizábal Leyre , Bartomeus Ígnasi , Molina Morales Mercedes , Sobral Mar , Benavides Raquel , C Bastias Cristina , Pérez-Luque Antonio Jesús , Garrido-Bautista Jorge , Villellas Jesús , Palencia Pablo , Miquelajauregui Yosune , Pérez-Méndez Néstor , Lacerot Gissell , Astigarraga Julen , Viota María , Álvarez-Martínez Jose Manuel , Clemente-Orta Gemma , Montagud Daniel , Cruz-Alonso Verónica
Published: April 2024

Acknowledgement to reviewers and guest editors of ECOSISTEMAS in the year 2023