bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigation of health-promoting behaviors of employees of medical university
Authors: Ghorabi Samaneh Tahmasebi , Jalilian Mohsen , Sadeghifar Jamil , Zavareh Mohammad Sadegh Abedzadeh
Published: April 2024

BACKGROUND:

Employees spend most of their time at work, and hence, it is important to pay attention to health-promoting behaviors. The purpose of the present study was to investigate the status of health-promoting behaviors of employees in the Medical University of Ilam-Iran.

MATERIALS AND METHODS:

This cross-sectional, descriptive study has been conducted by the participation of 208 employees, whom selected through the simple random sampling method. In the present study, participants completed Walker's Health Promoting Life Style Profile II in the self-report form. The gathered data were analyzed using software at the significant level of 0.05. Data were analyzed by the independent samples t-test, one-way analysis of variance, and Pearson correlation coefficients.

RESULTS:

The highest correlation of health-promoting behaviors was related to spiritual growth (r = 0.785), stress management (r = 0.777), interpersonal relationships (r = 0.767), health responsibility (r = 0.730), nutrition behaviors (r = 0.641), and physical activity (r = 0.611) were in the next places (P < 0.001), respectively. Among sub-scales, the highest correlation was observed between spiritual growth and stress management (r = 0.676, P < 0.001) and the lowest correlation between physical activity and interpersonal relationships (r = 0.253, P < 0.001).

CONCLUSIONS:

The score of physical activity was lower compared to other dimensions of health promoting behaviors. Therefore, it is necessary to make more effective interventional measures for improving physical activity status.
Role of mental health in prediction of sexual function in infertile women, Babol, Iran
Authors: Pasha Hajar , Faramarzi Mahbobeh , Basirat Zahra , Kheirkhah Farzan , Adib-Rad Hajar
Published: April 2024

BACKGROUND:

Infertility is one of the main concerns in women's lives that may lead to psychological imbalance and disrupt their sexual relationship. The study was conducted with the aim of evaluating role of mental health in prediction of sexual function in infertile women.

MATERIALS AND METHODS:

This analytic-descriptive study was conducted in 2015–2016 in 424 infertile women referring to Fatemeh Zahraa Infertility and Reproductive Health Center, Babol, Iran. The participants filled out the Female Sexual Function Index (α = 0.72–0.90), General Health Questionnaire (GHQ-28, α = 0.86), and demographics questionnaires. Linear regression used to analyze the data.

RESULTS:

The mean of total GHQ was 23.57 ± 12.06. The highest mean of GHQ subscales was social dysfunction (8.68 ± 3.69). There was a negative association between GHQ with the overall sexual function of infertile women (r = −0.397, P < 0.0001). The higher mental health disorder was associated with lower sexual function. Furthermore, there was an inverse significant association between all the subscales of mental health and sexual function. Based on the multiple linear regression analysis, the variables of anxiety and sleep disorder (β = −0.143, P < 0.035), social dysfunction (β= −0.139, P < 0.003), depression symptoms (β = −0.121, P < 0.046), sexual intercourse frequency (β = 0.272, P < 0.0001), and educational level (β = −0.110, P < 0.016) were the significant predictors of perceived sexual dysfunction after adjusting for other variables. The strongest predictor of the GHQ subscale was anxiety and sleep disorder.

CONCLUSIONS:

Undesirable conditions of mental health and its adverse effects on sexual function and also other predictors emphasize the need to develop more effective screening and supportive strategies with the help of the psychologists.
Providing and promoting health-oriented services by nongovernmental organizations
Authors: Saber Maryam , Haghdoost AliAkbar , Taghdisi Mohammad-Hossein , Eftekhar Hassan , Safinejad Hadise , Mehri Ali
Published: April 2024

BACKGROUND:

Benefactors of nongovernmental organizations (NGOs) are the hidden public health promotion systems. These benefactors are the symbol and intermediary of people participation, which is one of the main arms of health promotion and reduction of poverty and injustice in the societies. The present study is aimed to identify the benefactors’ experiences in NGOs in terms of providing and promoting health-oriented services.

MATERIALS AND METHODS:

This study was conducted with a qualitative approach. The total number of participants was 32, which consisted of 25 chief executive officers from active and inactive organizations. Active organizations refer to organizations that submitted their 6-month report at the time of the investigation and whose operating license was renewed and in operation and seven officials of the social deputy of governmental organizations related to NGOs. Data collection was performed by using semi-structured interviews and with purposive sampling and then continued until data saturation. Furthermore, the content analysis method was used for data analysis. MAXQDA software version 2007 was used to manage quality data.

RESULTS:

During the data analysis, the following four subcategories were obtained: “high effort in empathy with fellow human beings,” “role of merit in the success of donors,” “creating a platform for social attention for the client's spontaneity,” and “respect of the client,” which were the results of experience and dimensions. The performance of non-governmental organizations is in line with the confrontation and responsibility of non-governmental organizations with a focus on health-oriented services.

CONCLUSION:

Having benevolent motives, benefactors attempt to provide conditions, in which help seekers have more chance for living through establishing new, sustainable, and future-reassuring conditions.
The components of diabetes educator's competence in diabetes self-management education in Iran
Authors: Kashani Fahimeh , Abazari Parvaneh , Haghani Fariba
Published: April 2024

BACKGROUND:

Limited research has been conducted in the field of diabetes educator's competency. However, no comprehensive and integrated explanations of educator's competence requirements in treatment centers exist in Iran. The aim of this study is to explain the components of diabetes educator's competence in diabetes self-management education in Iran.

MATERIALS AND METHODS:

This was a qualitative descriptive-exploratory study. The data were collected through semi-structured and in-depth interviews and using purposeful sampling method in Isfahan University of medical science from April to October 2018. Sampling continued until data saturation. Participants included 20 people who were selected by purposive and snowball sampling method. The interviews were analyzed using content analysis method of Graneheim, Lundman.

RESULTS:

Data analysis resulted in the emergence of three main categories including (1) Patient and family centered education, (2) process-based education, and (3) continuous progress in profession and also seven subcategories (patient and family activation, empower), facilitating educational process, comprehensive education assessment, development, implementation and evaluation of educational plans, developing educators’ educational knowledge and skills, development of creativity and innovation, promote inter-professional cooperation in education.

CONCLUSION:

The evaluation of facilitation factors for participation and empowerment patient and family along with creativity and interprofessional collaboration for comprehensive evaluation of patients in designing, implementation of educational programs were mentioned as important competencies of diabetes educators, which can have a significant impact on patients’ recovery, treatment, and the promotion of society's health.
Comparing the effect of electronic and lecture education of pain management on the knowledge, attitude, and practice of nurses
Authors: Farshbaf-Khalili Azizeh , Jasemi Madine , Seyyedzavvar Atefe
Published: April 2024

INTRODUCTION:

Efficient pain management by nursing staff initially needs accurate knowledge and proper attitude in this field. The aim of present study was to compare the effects of lecture and electronic education on the knowledge, attitude, and practice of nursing staff regarding pain management.

MATERIALS AND METHODS:

The present superiority randomized controlled trial with two parallel arms was conducted on 78 occupied nurses of surgery wards of X. The participants were recruited randomly and divided into two groups of lecture and electronic education through random blocking (4 and 6 blocks). For allocation concealment, coded nontransparent pockets numbered 1–78 containing the type of intervention were used. Educational material was presented using teacher-centered method in lecture group, as well as through multimedia program using FLASH software in e-learning group through 1-h sessions for 4 weeks. Data on nurses were collected before and 4 weeks after the training using demographic questionnaire, Pain Management Principles Assessment Tool, Nurses’ Attitude Survey, and nursing practice checklist. Data were analyzed using SPSS software (version 24) utilizing descriptive and analytic statistical test such as Chi-square, Fisher, independent t-test, and ANCOVA. P < 0.05 was considered statistically significant.

RESULTS:

Mean ± standard deviation of nurses’ knowledge, attitude, and practice regarding pain management had significant increase in both groups post-training (P < 0.001). According to ANCOVA the mean postintervention knowledge score in e-learning group by controlling baseline score had significant increase compared to the lecture group (adjusted mean difference [aMD] = 1.8: 95% confidence interval [CI] = 1.5–2.1, P < 0.001). Furthermore, the mean of total scores of post-intervention attitude and practice in e-learning group adjusted for baseline score significantly increased compared to lecture group (aMD = 1.8: 95% CI = 1.5–2.1, P < 0.001) and (aMD = 3.2: 95% CI = 2.7–3.6, P < 0.001).

CONCLUSION:

Electronic education was more efficient than lecture education in increasing of knowledge, attitude, and practice on pain management among nursing staff.
Exploring Iranian married working women's experiences regarding sexual health challenges
Authors: Abadian Khadige , Keshavarz Zohreh , Milani Hourieh Shamshiri , Hamdieh Mostafa , Nasiri Maliheh
Published: April 2024

BACKGROUND:

Considering that the quality of personal life and the quality of sexual life of working women interact with each other and considering that job as one of the dimensions that can play a direct role in the quality of life and also due to increasing women's participation in professional activities in today's society, this study was designed and conducted to explain the experiences of working women considering sexual health challenges.

MATERIALS AND METHODS:

This research was a qualitative study that the information of which was obtained through face-to-face interviews with semi-structured and open-ended questionnaires. Interviews were conducted with 32 working women working in public and private offices in Tehran, Iran, to explore their experiences of the role of jobs in sexual challenges. The sampling method was purposive. Data analysis was performed using a qualitative content analysis method with a conventional approach by MAXQDA software version 10, and to establish the reliability and validity of findings, Graneheim and Lundman criteria were considered.

RESULTS:

Data analysis from 32 interviews resulted in the formation of 223 primary inferential codes and 1 main category and 4 subcategories. The results of data analysis were presented in one main category, including sexual health challenges among working women. This main category consisted of four subcategories such as sexual problems due to employment, job harassment, the essential needs for sexual relationship, need for the better job management, and married sex life.

CONCLUSIONS:

Explaining the experiences of working women showed that sexual problems due to employment and job harassment are among the factors that cause sexual health challenges in working women. It also seems that meeting the essential needs for sexual relationship and the better management of job and married sex life can interact with the sex lives of working women.
The effect of cognitive–behavioral counseling of pregnant women with the presence of a spouse on stress, anxiety, and postpartum depression
Authors: Dafei Maryam , Mojahed Shahnaz , Dastjerdi Ghasem , Dehghani Ali , Ardakani Tayebeh Shojaaddini
Published: April 2024

BACKGROUND:

Pregnant women are classified as one of the vulnerable groups. Physiological and psychological changes during pregnancy predispose them to serious psychiatric disorders; if not identified and treated in time, it can have a negative and long-term impact on mental health. The aim of this study was to determine the effect of cognitive–behavioral counseling of pregnant women with the presence of a spouse on the level of stress, anxiety, and postpartum depression.

MATERIALS AND METHODS:

The present study is a clinical trial that was performed on 40 pregnant women with a gestational age of 32–28 weeks (20 in the intervention group, 20 in the control group) who were randomly assigned to the intervention group and the control group according to the inclusion criteria. Cognitive–behavioral group counseling in the presence of spouses was performed by the midwife and under the supervision of a psychologist, in eight sessions, each session lasting 90 min, once a week for the intervention group. The control group received routine care and a counseling session. Data collection tools were demographic information questionnaire and Depression–Anxiety–Stress Scale 21, which were completed before the intervention, immediately after the intervention, and on the 14th day after delivery in both groups. Data analysis was performed using statistical tests, independent t-test, repeated measures test, Bonferroni post hoc test, and Kolmogorov–Smirnov test.

RESULTS:

The results of this study showed that the mean scores of stress, anxiety, and depression in the two groups in the preintervention stage were not significantly different (P < 0.05), but in the postintervention stage and follow-up, the mean scores of stress (P < 0.001), depression (P = 0.010), and anxiety (P = 0.029) in the intervention group were significantly reduced compared to the control group.

CONCLUSION:

According to the research findings, cognitive–behavioral group counseling can be effective as an approach in improving the symptoms of stress, anxiety, and depression in pregnant women. Therefore, it is necessary to plan properly to use this counseling approach to manage stress, anxiety, and depression in women during pregnancy.
Predictors and prevalence of periodontitis among pregnant women of slum areas of Patna, India
Authors: Singh Supriya , Nazeer Jazib , Singh Revati , Kavita Kumari , Iqubal Md Asad , Singh Rohit
Published: April 2024

BACKGROUND:

There is abundant documentation in literature that presence of maternal periodontal infections has been attributed to serious health problem to the mother and the child. Regular evaluation of any illness burden is required for planning preventive and treatment strategies and fills the existing health gap. There is a lack of literature about the predictors and prevalence of periodontal diseases in expectant women in the slum areas of Patna.

MATERIALS AND METHODS:

It was a cross-sectional study conducted on pregnant women of slum areas of Patna, Bihar, by convenience sampling method. Using a questionnaire, data collection was carried for demographic and oral hygiene habits information. Periodontal examination was done using modified community periodontal index criteria (WHO, 2013) by recording bleeding on probing (BoP), periodontal pockets (PD) and loss of attachment (LoA). The prevalence of potential predictors was estimated and bivariate analysis was performed with BoP, PD, and LoA and then to explore the prevalence of odds ratio (ORs) multivariate logistic regression framework was employed. The level of significance was kept at P < 0.05.

RESULTS:

A higher level of BoP and PD was observed among women who had the habit of cleaning their teeth once daily a day than those who cleaned their teeth with brush twice a day. Oral cleanliness (hygiene) frequency established the maximum OR of 2.77 (2.07–3.71) for BoP. Gingival bleeding robustly was related with PD. Among all multivariate framework of predictors of LoA, BoP, and PD came as the firmest predictors.

CONCLUSION:

Teaching correctly how to maintain oral hygiene and periodic periodontal check-up can improvise the general well-being and adverse pregnancy outcomes can be lessened.
Criteria and components of the emergency and disaster database in Iran
Authors: Mazhin Sadegh Ahmadi , Farrokhi Mehrdad , Noroozi Mehdi , Roudini Juliet , Hosseini Seyed Ali , Motlagh Mohammad Esmaeil , Kolivand Pirhossein , Khankeh Hamidreza
Published: April 2024

BACKGROUND:

Nowadays, emergencies and disasters are considered one of the biggest problems in human life. To reduce the risk of emergencies and disasters, governments must develop strategies and policies using evidence-based methods. Disaster databases are the main source and tool for storing and managing a wide range of data in this field. This study was conducted with the aim of exploring the necessary criteria and components of the emergency and disasters database in Iran.

MARTIALS AND METHODS:

This qualitative study was performed using content analysis in which 18 managers and experts with experience in registering, documenting, or responding to emergencies and disasters were selected through purposive sampling. Data collection was done using semi-structured interviews that continued until saturation. Data were analyzed by means of qualitative content analysis recommended by Landman and Graneheim.

RESULTS:

In total, three main concepts concerning the necessary criteria and components of the database of natural and artificial emergencies and disasters in Iran were explored. The main concepts include information resources, information evaluation, and information management. Subconcepts include data collection, information transfer, access to information, information validation, disaster leveling, information registering, information storage and retrieval, information analysis, and information dissemination.

CONCLUSION:

The experience of the participants showed that there are many challenges in the field of monitoring and gathering information about injuries and damages caused by emergencies and disasters in the country. The knowledge obtained from this study can be used to create and develop a database of emergencies and disasters in Iran. It will also provide insights for healthcare policymakers and managers in future planning areas to more effectively address identified challenges in preventing and responding to disasters at both regional and national levels.
Prevalence of primary osteoporosis and low bone mass in postmenopausal women and related risk factors
Authors: Hemmati Elnaz , Mirghafourvand Mojgan , Mobasseri Majid , Shakouri Seyed Kazem , Mikaeli Parvaneh , Farshbaf-Khalili Azizeh
Published: April 2024

BACKGROUND:

Globally, 30% of female over 50 years old have osteoporosis. This disease is one of the major causes of disability and death in the elderly. This research was aimed to determine the prevalence of primary osteoporosis and low bone density based on bone mineral density in postmenopausal women and its sociodemographic, obstetric, and life style risk factors.

MATERIALS AND METHODS:

This cross-sectional descriptive-analytical study was performed by simple random sampling on 850 postmenopausal women aged 50–65 years covered by all health centers, from August 2018 to April 2019, in Tabriz-Iran. Four hundred and forty-five eligible women underwent densitometry using dual-energy X-ray absorptiometry in the lumbar spine and femoral neck. Socio-individual, obstetric-medical, international physical activity questionnaires-short form, and anthropometric questionnaires were completed. Data analyzed using descriptive and analytical statistics including multivariate logistic regression in SPSS 21 software.

RESULTS:

The prevalence of primary osteoporosis based on lumbar vertebra T-score, femoral neck T-score, and total was 23.4%, 3.4%, and 24.5%, respectively, and the prevalence of primary osteopenia based on lumbar vertebra T-score, femur neck T-score, and total was 42%, 35.5%, and 43.6%, respectively. The present study showed that the odds of osteoporosis increased by increment of age (odds ratio [OR]: 1.18; 95% confidence interval [CI]: 1.07–1.30), but it decreased by increasing menopausal age (OR: 0.92; 95% CI: 0.85–1.01), body mass index (OR: 0.87; 95% CI: 0.78–0.97), arm circumference (OR: 0.84; 95% CI: 0.74–0.95), and education level (P = 0.028). It was higher in unmarried women (OR: 2.65; 95% CI: 0.99–7.08) and those with nonpersonal housing (OR: 4.02; 95% CI: 1.24–13.07).

CONCLUSIONS:

Given the high prevalence of primary osteoporosis and low bone mass in postmenopausal women, health education is necessary for preventing modifiable risk factors and reducing the complications of this disease.
Approaches and perspectives for online learning during the COVID-19 pandemic and future chaos
Authors: Nesar Shagufta , Rafiq Kiran , Rizwan Muhammad , Hasan Syed Mehmood
Published: April 2024

BACKGROUND:

Online learning (OLL) methodology has been incorporated in higher education extensively on the mount over the last few decades and with the onset of COVID-19 situation, the virtual method in academia became essential. After observing worldly destructions and death due to coronavirus, the WHO declared a high alert emergency, and since Pakistan started to follow lockdown since March 2020 to prevent high penetration and consequently, the online teaching method was adapted to keep the learning atmosphere alive. The study is aimed to identify the influencing factors and compliance for the implementation of the OLL system in COVID-19 and, in the future, nonpandemic state as well.

MATERIALS AND METHODS:

The present study is designed to observe the adaptability and hurdles among pharmacy students, and for the purpose of the study, a questionnaire on the Likert scale was developed and asked to respond from pharmacy undergraduate and postgraduate students after taking consensus, which further analyzed through IBM SPSS Statistics Version 26.

RESULTS:

The outcomes of the study were analyzed with a high level of conformity; however, the gender-based reservations were observed, and moreover, merits of OLL were observed with high jeopardy.

CONCLUSION:

The adaptation of OLL, though proved as the only troubleshooter in an uncontrollable situation and enabled universities, professors, and students for patience, resilience, and hopefully, will serve as swift safeguard for future challenges of epidemic and pandemic disasters. According to the evolution theory, brain adaptability and plasticity of human organisms grow the capacity to adjust itself with an advanced characteristic.
The relationship between emotional intelligence, social responsibility, and job performance in health service providers
Authors: Najimi Arash , Doustmohamadi Parvin , Omid Athar
Published: April 2024

BACKGROUND:

Responsibility of individuals in adapting to life events depends on the intertwined cooperation of intellectual and emotional capacities, and a person's success in life depends on his emotional responses. Given that health-care providers are at the forefront of providing health services, they need to improve their job performance with better control of their emotions and better social relationships. The aim of this study was to determine the relationship between emotional intelligence, social responsibility, and job performance in health-care providers and caregivers.

MATERIALS AND METHODS:

A cross-sectional correlational study was performed on 270 health workers working in the western cities of Isfahan province in the first quarter of 1998 by random classification sampling method. To collect information, two questionnaires of Bradbury emotional intelligence, responsibility, social responsibility, whose validity and reliability had been proven in previous studies, and job performance scores of the samples were used. The collected data were analyzed using descriptive tests and Pearson correlation.

RESULTS:

The participants were 270 health workers and caregivers with a mean age of 34.54 ± 7.26. 87.5% of the samples were female and 21.5% were male. The mean score of social responsibility was 124.95 ± 10.41, the mean score of emotional intelligence was 125.58 ± 15.86, and the mean score of job performance was 86.91 ± 9.0.18. The results of Pearson correlation showed that all four components of social responsibility and total emotional intelligence have a significant correlation at the level of 0.01. Total emotional intelligence and each of its components did not show a significant correlation with job performance. Between social responsibility and job performance of health workers, only the moral component significantly predicts job performance (r = 0.133 and P = 0.026).

CONCLUSION:

Although the results of the study showed that the job performance, social responsibility, and emotional intelligence of the study group were desirable, the score of some components of social responsibility and emotional intelligence is lower than their maximum score. In addition, according to the results of the study that showed the relationship between emotional intelligence and social responsibility and some of their components with job performance, improving the knowledge and skills of health-care providers and caregivers in the field of social responsibility and emotional intelligence and their components seems necessary.
Factors affecting substance use relapse among Iranian addicts
Authors: Mousali Amir Abbas , Bashirian Saeed , Barati Majid , Mohammadi Younes , Moeini Babak , Moradveisi Latif , Sharma Manoj
Published: April 2024

BACKGROUND:

Substance use relapse after treatment is one of the most important aspects of addiction. The present study aimed to investigate the factors affecting the substance use relapse among Iranian addicts.

MATERIALS AND METHODS:

This cross-sectional study was conducted in 2019 on 396 addicts referring to the addiction treatment centers in Hamadan, who were selected using a cluster random sampling method. The data were collected by a two-section questionnaire (demographic variables and risk factors for substance abuse recurrence). The collected data were analyzed using descriptive statistics and logistic regression analysis.

RESULTS:

The participants' mean (standard deviation) age was 36.56 (8.8) years, and 84.6% of the participants had a history of relapse. The logistic regression analysis revealed that marital status (odds ratio [OR] = 2.594; 95% confidence interval [CI]: 1.472–4.570), personal willingness (OR = 8.186; 95% CI: 1.875–35.738), pleasure (OR = 2.738; 95% CI: 1.122–6.679), drug availability (OR = 3.392; 95% CI: 1.023–11.247), family disputes (OR = 4.583; 95% CI: 1.345–15.609), an addicted friend (OR = 2.693; 95% CI: 1.014–7.157), and close addicted relatives (OR = 3.513;95% CI: 1.193–10.348) were the main predictors of addiction relapse (P < 0.05).

CONCLUSION:

The present study confirmed the effect of several factors (namely demographic, individual, interpersonal, environmental, and behavioral) on the substance use relapse. Accordingly, designing and implementing some interventions based on the findings of the present study may contribute to preventing substance use relapse.
The social-cognitive determinants of calcium intake for preventing osteoporosis in women in Isfahan
Authors: Nematollahi Mahin , Eslami Ahmad Ali
Published: April 2024

BACKGROUND:

Osteoporosis is a common disease in women over age 45 years. Calcium intake is among the factors that help prevent osteoporosis. Identifying the social-cognitive determinants of calcium intake can have a major role in the development of osteoporosis prevention programs.

MATERIALS AND METHODS:

This cross-sectional study was conducted on 400 women aged <50 years from 10 health centers by cluster sampling in Isfahan in 2016. A hypothetical social-cognitive model was assessed using path analysis, and the fit indices and explanatory power of the model were assessed. The constructs, including self-efficacy, outcome expectations, social support, and self-regulation, were taken as the explanatory variables and calcium intake as the criterion variable.

RESULTS:

The mean age of the participating women was 34.07 years (standard deviation = 7.99) (range = 19–50), and their mean calcium intake was reported as 909.94 (12. 6) mg/day. The conceptual model was able to explain 73% of the variance in calcium intake and had good fit indices. Self-regulation was identified as the strongest predictor of calcium intake, and outcome expectation was eliminated from the model since it was the weakest explanatory factor of calcium intake.

CONCLUSIONS:

The theoretical model of this study is recommended as a suitable framework for the development of targeted osteoporosis prevention interventions.
Cytotoxic effect of dental luting cement on human gingival mesenchymal stem cell and evaluation of cytokines and growth factor release – An in vitro study
Authors: Jain Iti , Anasane Nayana , Jagtap Amit
Published: April 2024

Aim:

In routine dental care, various dental luting cements are utilized to cement the dental prosthesis. Thus, the aim of the current study was to assess the Cytotoxic effect of three different dental luting cements on human gingival mesenchymal stem cell and evaluation of cytokines and growth factors release.

Settings and Design:

Cytotoxicity of glass ionomer cement (GIC), resin modified glass ionomer cement (RMGIC) and resin cement (RC) on the human gingival mesenchymal stem cells (HGMSCs) was evaluated. Amongst the cements tested, least cytotoxic cement was further tested for the release of cytokines and growth factors.

Materials and Methods:

MTT test was used to evaluate the cytotoxicity of the dental luting cements at 1 h, 24 h, and 48 h on HGMSCs. Cytokines such as interleukin (IL) 1α & IL 8 and growth factors such as platelet derived growth factor & transforming growth factor beta release from the least cytotoxic RC was evaluated using flow cytometry analysis.

Statistical Analysis Used:

The mean absorbance values by MTT assay and cell viability at various time intervals between four groups were compared using a one way analysis of variance test and Tukey’s post hoc test. The least cytotoxic RC group and the control group’s mean levels of cytokines and growth factors were compared using the Mann–Whitney test.

Result:

As exposure time increased, the dental luting cement examined in this study were cytotoxic. RC was the least cytotoxic, RMGIC was moderate and glass ionomer cement showed the highest cytotoxic effect. Concomitantly, a significant positive biological response of gingival mesenchymal stem cells with the release of ILs when exposed to the RC was observed.

Conclusion:

For a fixed dental prosthesis to be clinically successful over the long term, it is imperative that the biocompatibility of the luting cement be taken into account in order to maintain a healthy periodontium surrounding the restoration.
Does the choice of the measuring technique affect the comparison of fit between zirconia and cobalt–chromium prostheses?
Authors: Daou Elie E. , Salameh Pascale
Published: April 2024

Aims:

The objectives of the study were to compare the adaptation of presintered zirconia and cobalt– chromium prostheses using microcomputed tomography (μCT), scanning electron microscopy (SEM), and stereomicroscope (SM).

Materials and Methods:

Twenty-four fixed dental prostheses (FDPs) were fabricated on metal abutments, duplicated from maxillary first premolar and first molar prepared on a typodont model. Teeth were reduced to obtain chamfer of 1.2 mm and reduction occlusaly of 2 mm occlusal. Scanning of the abutments was done with random assignment to two groups receiving the FDPs made from soft-milled Co-Cr (n = 12) and zirconia (n = 12). Marginal and internal gaps were assessed using three evaluation techniques (X-ray microcomputer tomography, SEM, and stereomicroscopy).

Statistical Analysis Used:

Comparison of the results was made using Levene and analysis of variance tests (α =0.05).

Results:

Irrespective of the material tested, statistical differences were found between the measuring techniques (P = 0.001 overall); the obtained mean gaps were for CT scan (92.60 ± 13.31), for SEM (101.92 ± 23.03), and for SM (113.44 ± 14.68): the multiple comparisons between techniques found a significant difference between CT and SM (P < 0.001), and SEM and SM (P = 0.025). When materials were compared within each measuring technique, Co-Cr showed lower values compared to zirconia in SEM (P < 0.001) and Stereo (P = 0.049); similar results were found in CT.

Conclusions:

Results values differed with the chosen measuring technique. Co-Cr prostheses had a better fit than zirconia prostheses in SEM and Stereo. µCT showed comparable results to SEM, smaller than SM results.
A newly proposed classification for articulators-integrating virtual with conventional
Authors: Maheshwari Komal , Gupta Abhishek Kumar , Tiwari Bhawana
Published: April 2024

A new and simple articulator classification has been proposed which includes both mechanical and virtual articulators to meet with the modern day dental practice that has shown a gradual shift toward digital technology and workflow.
Subellipticity, compactness, $H^{\epsilon}$ estimates and regularity for $\bar{\partial}$ on weakly $q$-pseudoconvex/concave domains
Authors: Saber Sayed , Youssif Mukhtar , Arko Yagoub , Elziber Omar , Osman Mohammed , Adam Khalid , Adam Haroun
Published: April 2024

For a weakly

q

-pseudoconvex (resp.

q

-pseudoconcave) domain

\Omega

in a Stein manifold

X

of dimension

n

, we give a sufficient condition for subelliptic estimates for the

\bar{\partial}

-Neumann problem. Moreover, we study the compactness of the

\bar{\partial}

-Neumann operator

N

on

\Omega

. Such compactness estimates immediately lead to smoothness of solutions, the closed range property, the

L^{2}

-setting and the Sobolev estimates of

N

on

\Omega

for any

\bar{\partial}

-closed

(r, k)

-form with

k \geqslant q

(resp.

k \leqslant q

). Furthermore, we study the

\bar{\partial}

-problem with support conditions in

\Omega

for forms of type

(r, k)

, with values in a holomorphic vector bundle. Applications to the

\bar{\partial}_{b}

-problem for smooth forms on boundaries of

\Omega

are given.
Associations of Serum Isoleucine with Mild Cognitive Impairment and Alzheimer’s Disease
Authors: Jing Xiao-jun , Zan Zhi-yuan , Zhou Xin , Xiong Yong-lan , Ren Shu-jiang , Zhang Hua ,   the Alzheimer’s Disease Neuroimaging Initiative
Published: April 2024

Background: Advances in blood biomarker discovery have enabled the improved diagnosis and prognosis of Alzheimer's disease (AD). Most branched-chain amino acids, except isoleucine (Ile), are correlated with both mild cognitive impairment (MCI) and AD. Therefore, this study investigated the association between serum Ile levels and MCI/AD.Methods: This study stratified 700 participants from the Alzheimer's Disease Neuroimaging Initiative database into four diagnostic groups: cognitively normal, stable MCI, progressive MCI, and AD. Analysis of covariance and chi-square analyses were used to test the demographic data. Receiver operating curve analyses were used to calculate the diagnostic accuracy of different biomarkers and were compared by MedCalc 20. Additionally, Cox proportional hazards models were used to measure the ability of serum Ile levels to predict disease conversion. Finally, a linear mixed-effects model was used to evaluate the associations between serum Ile levels and cognition, brain structure, and metabolism. Results: Serum Ile concentration was decreased in AD and demonstrated significant diagnostic efficacy. The combination of serum Ile and cerebrospinal fluid (CSF) phosphorylated tau (P-tau) improved the diagnostic accuracy in AD compared to total tau (T-tau) alone. Serum Ile levels significantly predicted the conversion from MCI to AD (cutoff value of 78.3 μM). Finally, the results of this study also revealed a correlation between serum Ile levels and the Alzheimer's Disease Assessment Scale cognitive subscale Q4. Conclusions: Serum Ile may be a potential biomarker of AD. Ile had independent diagnostic efficacy and significantly improved the diagnostic accuracy of CSF P-tau in AD. MCI patients with a lower serum Ile level had a higher risk of progression to AD and a worse cognition assessment.
Optimal Portfolio Using Single Index Model (SIM) For Health Sector Stocks
Authors: Wijaya Silvia , Subartini Betty , Riaman Riaman
Published: April 2024

Investment is one of the fund management activities with the aim of obtaining future profits. In addition to profits, investors also need to consider the risks that will be faced by diversifying. Diversification is done by forming an optimal portfolio. This research aims to determine the proportion of stocks in the optimal portfolio and calculate the expected return and risk value of the optimal portfolio. The object used to form the optimal portfolio is health sector stock group for the period January 2020 - December 2022. The method used to form the optimal portfolio is Single Index Model (SIM). The results showed that there were 6 combinations of health sector stock in the optimal portfolio, such as IRRA, PRDA, SAME, SILO, MERK, and HEAL stocks of 8.94%, 9.24%, 9.34%, 11.92%, 27.15%, and 33.41% respectively with expected return of 2.68% and a risk value of 1.85%.
Investment Portfolio Optimization In Infrastructure Stocks Using The Mean-VaR Risk Tolerance Model
Authors: Yasmin Arla Aglia , Riaman Riaman , Sukono Sukono
Published: April 2024

Infrastructure a crucial role in economic development and the achievement of Sustainable Development Goals (SDGs), with investment being a key activity supporting this. Investment involves the allocation of assets with the expectation of gaining profit with minimal risk, making the selection of optimal investment portfolios crucial for investors. Therefore, the aim of this research is to identify the optimal portfolio in infrastructure stocks using the Mean-VaR model. Through portfolio analysis, this study addresses two main issues: determining the optimal allocation for each infrastructure stock and formulating an optimal stock investment portfolio while minimizing risk and maximizing return. The methodology employed in this research is the Mean-VaR approach, which combines the advantages of Value at Risk (VaR) in risk measurement with consideration of return expectations. The findings indicate that eight infrastructure stocks meet the criteria for forming an optimal portfolio. The proportion of each stock in the optimal portfolio is as follows: ISAT (2.74%), TLKM (33.894%), JSMR (3.343%), BALI (0.102%), IPCC (5.044%), KEEN (14.792%), PTPW (25.863%), and AKRA (14.219%). The results of this study can serve as a foundation for better investment decision-making.
The first description of a rare monogenic disease with polymicrogyria caused by a pathogenic variant in the gene WASF1 in monozygotic twins
Authors: Kondakova Olga B. , Gudkova Anastasia P. , Grebenkin Dmitry I. , Demyanov Semen V. , Davydova Iuliia I. , Lyalina Anastasia A. , Kanivets Ilya V. , Zhanin Ilya S. , Pushkov Alexander A. , Savostyanov Kirill V.
Published: April 2024

Neurodevelopmental disorder without speech and variable seizures (NEDALVS) is a rare autosomal dominant inherited disorder, characterized by motor development delay, mental retardation, wide-based gait, autism spectrum disorders and seizures.
Currently, fifteen cases of NEDALVS have been described worldwide.
NEDALVS caused by mutations in the WASF1 gene, located on the long arm of chromosome 6. Nonsense-, missense-, frameshift mutations and large deletion have been described in WASF1 gene.
We present the clinical case of 9-year monozygotic NEDALVS twins, accompanied by cerebral pachygyria/polymicrogyria. DNA diagnostic was performed using full genome sequencing, followed by validation using Sanger sequencing. A previously described heterozygous pathogenic variant c.1516C>T (p.R506*) in the WASF1 gene was identified.
We performed the results of a comparative analysis based on the literature and our patients. All patients had delayed motor and psycho-speech development, severe mental retardation was in 53% of cases, lack of speech — 18%, autistic manifestations and seizures — 41%, wide-based gait — 29%, strabismus and feeding problems — 35%.
Conclusion. WASF1 gene mutations caused a rare form of mental retardation in children. We present the first case of NEDALVS in Russian Federation and the world’s first description of pachygyria in patients, caused by WASF1 gene mutations. The use of NGS as a first-line test for research and diagnostic of neurodevelopmental disorder is determined by their non-specific clinical features.
Assessment of genetic markers associated with the development of bronchopulmonary dysplasia in premature infants in the structure of a prognostic model of its development
Authors: Basargina Milana A. , Fisenko Andrey P. , Pushkov Alexander A. , Zhanin Ilya S. , Bondar Valeria A. , Savostyanov Kirill V. , Davydova Irina V.
Published: April 2024

Introduction. Bronchopulmonary dysplasia (BPD) is a complex disease with a significant genetic predisposition. The aim of the study was to determine genetic markers associated with the development of bronchopulmonary dysplasia in premature infants.
Materials and methods. At Stage 1, whole exome sequencing followed by the bioinformatic analysis of one hundred samples was provided to evaluate the genetic variants. Sequencing data were compared with the data of the children without any congenital pulmonary diseases. At Stage 2, the obtained results were validated using real-time PCR. Further the genotyping of the control group (n = 70) was performed. The obtained frequencies of nucleotide variants were compared between the groups, as well as with general population data using the RUSeq database.
Results. The prevalence of genetic variant rs12489516 in gene CPA3 was significantly higher in the control group of premature infants (p = 0.03; OR = 0.2; 95% CI: 0.02–0.94). Its presence in the genotype reduces the likelihood of developing BPD by 4.76 times. Moreover, statistically significant differences were also identified in the prevalence of rs45488997 in gene CCN2 (p = 0.023). This genetic variant was specific only for children with bronchopulmonary dysplasia. It was also identified that the prevalence of the nucleotide variant rs45488997 in the CCN2 gene was statistically more common among patients with bronchopulmonary dysplasia compared with the general population (p = 0.005). In addition, genetic variants rs5744174 in gene TLR5 and rs2476601 in gene PTPN22 were less frequently observed in the investigated group compared to the general population (p = 0.03 and p = 0.003, respectively).
Conclusion. Identification of genetic markers together with clinical and laboratory data will contribute to the development of an effective predictive model for the calculation of the probability of BPD.
Implementasi Metode Sentra dalam Pembelajaran Bahasa Arab di Kelas IV SD Tazkia Global Islamic School
Authors: Qoimah Fidatul , Muttaqien Agung , Sudjani Desky Halim
Published: April 2024

This research aims to determine the planning, implementation, inhibiting and supporting factors of the central method in learning Arabic, especially maharah istima. The research method used in this research is a descriptive qualitative method. The data collection techniques used in this research are observation, interviews and documentation. The results of this research show that (1) There are 2 central method planning for learning Arabic, namely: Teacher mental preparation, Teacher administration, APE/Learning Tools (2) Implementation of the Arabic language learning process using the central method, there are 3, namely: Opening Activities, Activities core, and final activities. (3) There are 3 factors inhibiting the application of the central method in maharah istima' learning, namely: time effectiveness, lack of teacher creativity and student adjustment. (4) Supporting factors for the application of the central method in maharah istima' learning, there are 5, namely, infrastructure, special teacher training, teacher allowances, student motivation and support from parents, especially in class IV SD Tazkia Global Islamic School.
Workshop Pembuatan Storybook Tokoh Sejarah Joko Songo Di Kwartir Cabang Gerakan Pramuka Kabupaten Karanganyar
Authors: Syaifullah Jahid , Sari A Anditha
Published: April 2024

Pembelajaran sejarah sering dianggap pembelajaran yang kurang menarik oleh generasi milenial. Pembelajaran sejarah memiliki peranan untuk menghasilkan generasi yang dapat mengambil pembelajaran dan meneladani kisah para pahlawan. Strategi menciptakan proses pembelajaran sejarah yang efektif dapat dilakukan dengan menggunakan metode pembelajaran yang tepat. Buku cerita atau storybook merupakan salah satu media pembelajaran alternative yang berisi rangkuman peristiwa berupa gambar yang menjelaskan detail setiap peristiwa melalui nilai-nilai intrinsik yang dibangun berdasarkan data dan fakta yang terjadi di lapangan. Pembuatan storybook dengan menggunakan Adobe Indesign merupakan penyederhanaan konsep tutur serta narasi sejarah yang panjang menjadi sebuah ringkasan cerita dalam bentuk foto yang bercerita.Hasil dari pengabdian ini adalah didapatnya kriteria perancangan storybook dengan gaya visual, storyline, dan ilustrasi yang diminati target audience. Pembuatan Storybook berdasarkan kriteria desain yang diminati generasi milenial Gerakan Pramuka Kwartir Karanganyar. Nilai  edukasi dapat tersampaikan kepada anggota melalui media hiburan modern sehingga membuat anggota pramuka lebih mengapresiasi dan memahami nilai sejarah melalui edukasi yang disampaikan.
WORKSHOP KEWIRAUSAHAAN BERBASIS DIGITAL MARKETING DI SMK CORDOVA MARGOYOSO PATI
Authors: Tyas Maharani Ayuning , Dhani Putri Rahma
Published: April 2024

Perkembangan era digital membuka peluang yang cukup besar dalam pengembangan kewirausahaan berbasis digital marketing. Dengan dukungan ketersediaan internet dan perkembangan IPTEK, siapapun dapat mengembangakan wirausaha berbasis digital. Banyak platform yang bermunculan dan menawarkan fungsi sebagai market place. Hal ini tentu perlu menjadi perhatian karena membawa perubahan dan perkembangan ke berbagai lini, terutama pada kewirausahaan berbasis digital.  Siswa-siswi perlu mengetahui dan memahami peluang tersebut dikarenakan kedekatan generasi milenial dengan teknologi. Diharapkan kegiatan pengabdian tentang sosialisasi dan workshop kewirausahaan digital ini dapat menjadi inspirasi dan motivasi bagi generasi milenial untuk berwirausaha melalui media digital. Tujuan dari pengabdian ini adalah untuk menanamkan kesadaran pentingnya digitalisasi bagi para guru dan siswa-siswi di SMK Cordova Margoyoso. Kesadaran digitalisasi yang dimaksud adalah kesadaran mengenai pentingnya mengembangkan kewirausahaan digital dengan memanfaatkan media digital. Metode yang digunakan adalah metode pengabdian dengan pendekatan Service Learning (SL). Metode ini dipilih karena memiliki kedekatan dengan tujuan akademik dan melibatkan pengajaran. Melalui metode ini, peserta sosialisasi dan workhshop tidak hanya memahami materi yang disampaikan, melainkan juga dapat mengaplikasikan materi tersebut secara langsung. Hasil dari kegiatan pengabdian “Sosialisasi dan Workshop Kewirausahaan Berbasis Digital Marketing di Sekolah Menengah Kejuruan Cordova Margoyoso dalam Peningkatan Wawasan tentang Digitalisasi” adalah peserta memperoleh pemahaman tentang kiat-kiat dalam menjalankan kewirausahaan berbasis digital. Materi sosialisasi dan workshop dikemas dalam bentuk presentasi rancangan formula agar mudah dipahami sehingga dapat diaplikasikan oleh peserta dalam pengembangan kewirausahaan digital.