bluuebunny/crossref_metadata_2025 huggingface dataset:
DENTAL KAYGI VE AĞRI YÖNETİMİNDE NONFARMAKOLOJİK BİR YÖNTEM; AROMATERAPİ: DERLEME
Authors: MUTLU Büşra , AVŞAR Aysun
Published: April 2023

Aromaterapi, bitkilerden elde edilen esansiyel yağların kimyasal içeriklerine bağlı olarak değişen terapötik özelliklerine göre, fiziksel ve psikolojik olarak iyileştirmek amacıyla kullanılmasıdır. Uzun bir tarihsel geçmişe sahip olan ve günümüzde tamamlayıcı alternatif tıp tedavilerinden biri olarak kullanılan aromaterapinin uygulaması kolaydır, maaliyeti düşüktür ve yan etkisi yok denecek kadar azdır. Aromaterapi oral absorbsiyon, masaj ve inhalasyon yoluyla uygulanabilir. Uçucu yağlar inhale edildiklerinde burundaki reseptörler kokuları elektriksel impulslara çevirerek elektrokimyasal mesajları oluştururlar. Bu mesajlar olfaktör yol ile limbik sisteme iletilir, hipotalamus aracılığıyla koku alma sisteminden beyne sinyaller gönderilmesiyle seratonin ve dopamin gibi nörotransmitterler salgılanmasını gerçekleştirirler. Bunun sonucunda depresyon ve anksiyeteyi düzenleyerek analjezik ve anksiyolitik etki gösterirler. Aromaterapinin anksiyolitik ve analjezik etkisinden faydalanmak amacıyla tıp ve diş hekimliği alanında kullanımı yaygınlaşmıştır. Onkoloji tedavisi gören ve opere edilen hastaların anksiyete ve ağrı yönetiminde sıklıkla tamamlayıcı ve alternatif bir yöntem olarak tercih edilen aromaterapinin diş hekimliğinde tedavilerin karşısındaki en büyük küresel engellerden biri olan dental kaygının yönetiminde kullanımı son yıllarda artmıştır. Dental kaygı diş tedavileri konusunda anormal bir korku veya endişe olarak tanımlanmıştır ve çocuk hastalarda görülme sıklığı % 5-20 arasında değişmektedir. Günümüze dek yapılan çalışmalarla dental kaygıyı yönetmek amacıyla farmakolojik ve nonfarmakolojik çeşitli davranış yönlendirme teknikleri literatüre kazandırılmıştır. Dental kaygının yönetimindeki nonfarmakolojik güncel yaklaşımlardan biri olan aromaterapi kaygılı hastalarda ağrı duyarlılığı daha fazla gözlendiği için ağrı kontrolünde de kullanılabilmektedir.
Hydrological Modeling of the Cambamba Watershed in Angola Using the HEC-HMS Model
Authors:   Civil Engineering Department, Hydraulics, Water Resources, and Environment Division, Faculty of Engineering, University of Porto, Portugal, André Arlon
Published: April 2023

When evaluating the impact of climate change on water resources in river basins it is crucial to accurately estimate the availability of water and such can be attained through hydrological modeling of the basin. The studies of the Hydrological Modeling System (HEC-HMS) for the Cambamba River Basin in Angola has been calibrated and validated for the prediction of its hydrologic response. Due to the complexity of Hydrologic models, a good calibration of the model should be established, therefore, improving its skills and effectiveness. A combination of both the energy budget and a physically-based rainfall-runoff model, which are used for the estimation of lake evaporation, were applied in the lake water balance model. Soil storage, as well as groundwater storage coefficient, are essential parameters for estimating the simulated streamflow. For an adequate performance evaluation of the model which entails the simulation of the streamflow on Cambamba watershed and quantification of water availability, The Nash-Sutcliffe model efficiency criterion; root mean square error; percentage error in volume PEV; and percentage error in peak PEP, were implemented. Model performance is improved by using semiannual parameter sets that consider the change in hydrological conditions, as evaluated in this study. Key words: HEC-HMS, watershed, rainfall-runoff, flood hazards
Effective Change Management for Project Success
Authors:   Faculty of Natural Sciences and Mathematics, University of Montenegro, Montenegro, Nad Josip
Published: April 2023

Change management applies a structured approach to effectively transition individuals, business processes and organizations from the current to the desired future state. On an example of a corporate business project, the paper analyses three types of business changes that most often occur as a consequence of large-scale projects: changes in the functionality of equipment and systems, changes in regular business procedures, and changes in the organizational structure. The changes presented in the paper are caused by a powerful business requirement, accompanied by new equipment and devices, new rules, new positions and new individuals. The main activities pertaining to change management analyzed include drafting an activity plan, assessing the impact of change on business, communicating with all levels of business hierarchy, monitoring the implementation of all parts of the change, and planning and controlling the necessary educational and training programmes for all project participants and business users. The paper ends with the comparison of three basic ways of change management: mechanical management with strict adherence to previously defined procedures, experiential management with active action, and intuitive management with occasional participation in project management. Key words: changes, projects, change management
Measuring Students’ Sense of School Catholic Identity
Authors:   University of Notre Dame, Kowalski Monica J. , Dallavis Julie W. ,   University of Notre Dame, Ponisciak Stephen M. ,   University of Notre Dame, Svarovsky Gina ,   University of Notre Dame
Published: April 2023

As a ministry of the Catholic Church, Catholic schools are charged with educating stu­dents’ hearts and minds. Multiple standardized academic tests and other student assessments are available for monitoring both student and teacher outcomes in Catholic schools, but fewer measures exist for considering the school’s faith-related mission. Although tests of student religious knowledge and benchmarks related to specific Catholic elements of the school are available, we do not yet have a robust set of instruments that provide teachers and leaders an understanding of their progress in providing a school environment permeated by Catholic culture and faith. To consider how students in Catholic schools perceive the Catholicity of their school and how these perceptions vary among different student groups, we developed, piloted, and validated the Sense of School Catholic Iden­tity Survey (SSCI). This 20-­item survey measures Grade 5 through 8 students’ perceptions of their Catholic school as personal and invitational, sacramental, unitive, and eucharistic. Findings from the pilot study suggest that responses differ by student grade level, religious tradition, and gender. Future testing of the scale will examine school­-level differences in Catholic identity.
A Lance Distance-Based MAIRCA Method for q-Rung Orthopair Fuzzy MCDM with Completely Unknown Weight Information
Authors: Wang Haolun , Xu Tingjun , Pamucar Dragan , Li Xuxiang , Feng Liangqing
Published: April 2023

The purpose of this manuscript is to develop a novel MAIRCA (Multi-Attribute Ideal-Real Comparative Analysis) method to solve the MCDM (Multiple Criteria Decision-Making) problems with completely unknown weights in the q-rung orthopair fuzzy (q-ROF) setting. Firstly, the new concepts of q-ROF Lance distance are defined and some related properties are discussed in this paper, from which we establish the maximizing deviation method (MDM) model for q-ROF numbers to determine the optimal criteria weight. Then, the Lance distance-based MAIRCA (MAIRCA-L) method is designed. In it, the preference, theoretical and real evaluation matrices are calculated considering the interaction relationship in q-ROF numbers, and the q-ROF Lance distance is applied to obtain the gap matrix. Finally, we manifest the effectiveness and advantage of the q-ROF MAIRCA-L method by two numerical examples.
On the effectiveness of restorative justice in the ecocide crime
Authors: Babakhani Erfan
Published: April 2023

This paper will review some concepts elaborated upon by restorative justice and reflect on how some of them can be put in with the context of the ecocide crime. It can be said that this crime, as the fifth most serious crime against global peace, is a new threat for a human’s life. The crime of ecocide, especially its governmental and corporate types, severely damages and destroys the environment, and in addition to the threat it poses to environmental security, ecocide undermines the foundations of economic and social security. The author used a descriptive-analytical approach and library resources to study the process of invention of the concept of ecocide as well as its essence in restorative justice thought. The present study tries to show that restorative justice applied to ecocide crime is a justice that provides environmental revitalisation-reparation. This novel vision will attempt to provide judicial actors insights regarding the role played by restorative policies to restore or sustain ecological functioning in the promotion of human rights, survival of environment, and the diminishment of social suffering.
Climate change - a challenge and an opportunity for law and justice
Authors: Tiedeken Tjarda
Published: April 2023

The article “Der Klimawandel als Chance für die Beziehung zwischen Recht und Gerechtigkeit” aims to further the discussion on a possible justification of environmental activism (particularly in the German legal system). The author, Tjarda Tiedeken, finds that actions of climate change activists may fall under the definition of civil disobedience. She states that due to the superiority over ‘common’ crime and the relative effect of majority decisions, civil disobedience aiming to prevent state decisions with irreversible consequences must be justified. The author discusses the ‘irreversibility criterion’ as part of this justification, yet she finds it to lack differentiation causing a lack of practicability. Despite the unsuitability of the criterion examined, the author concludes that anyone who stands up against climate change for the preservation of democracy and even of humanity itself, cannot be treated like a person who transgresses the law out of pure self-interest. How a justification could be designed instead remains subject of further discussion, to which the author attempts to find an answer in her dissertation.
The intertemporal guarantee of freedom – a concept for international human rights to address states’ failure to combat climate change and its threats?
Authors: Gegenwart Matthias
Published: April 2023

This paper analyses, if the Intertemporal Guarantee of Freedom, that was developed by the German Federal Constitutional Court (GFCC), can be used to expand the protection of human rights against the harms of climate change. The case of the Swiss Senior Women shows that there are jurisdictions, where the Intertemporal Guarantee of Freedom could be applied to improve standing and the control standard of states’ climate change action. Within international law bodies with jurisdiction over human rights treaties there are distinctive standards of protection against the harms of climate change. A major deficit within the international human rights protection against climate change lies within the focus on the positive obligations and the corresponding wide margin of appreciation granted to the states. The Intertemporal Guarantee of Freedom could provide a protection expansion in this regard, especially in the case of the European Court of Human Rights. It could also enable and legitimise present human rights concerns focused on the future actions of states following their past inaction. One considerable hurdle that is not addressed by it are procedural hurdles like the Plaumann formula applied by the European Court of Justice. The Intertemporal Guarantee of Freedom cannot solve major problems for climate change litigation like procedural hurdles. Yet, it can provide a new approach for complaints to address unambitious mitigation legislation which will lead to future human rights infringements.
The convergence of judicial and administrative investigation techniques in French law
Authors: Guillard Antonin
Published: April 2023

Unsurprisingly, some of the prerogatives of the judicial police and the intelligence services are common. This is the case of human sources. Other acts, particularly those involving deprivation of liberty or intrusion into private life, are usually the responsibility of the judicial police. The commission of an offence and the control of the judicial authority justify restrictions on fundamental rights. This pattern is now disrupted because intelligence law is copying privacy-invasive mechanisms from the criminal procedure code. The convergence of these fields also has an interactive character, since techniques specifically developed for preventive law have recently been borrowed by repressive law. The legislator therefore uses the investigative techniques of each field to improve the other. This movement has an increasingly competitive character which seems to benefit the intelligence services. At this point, they have the most complex and intrusive acts at their disposal, which erodes the distinction between preventive and repressive action.
Stambiųjų arterijų atkeitimo operacijos rezultatai
Authors:   , Karolis Jonas
Published: April 2023

The results of the arterial switch operation
“To Call or Not to Call” Communication Preferences Among Pediatric Hospital Medicine Team Leaders
Authors: O’Hara Kimberly , Tseng Ashlie , Herbst Lori , Moss Stephanie , Marsicek Sarah , Herbst Brian , Molas-Torreblanca Kira , Maniscalco Jennifer , Ziniel Sonja I.
Published: April 2023

OBJECTIVES

Pediatric Hospital Medicine fellowship programs need to abide by Accreditation Council for Graduate Medical Education requirements regarding communication and supervision. Effective communication is critical for safe patient care, yet no prior research has explored optimal communication practices between residents, fellows, and attending hospitalists. Our objective is to explore communication preferences among pediatric senior residents (SRs), Pediatric Hospital Medicine fellows, and hospitalists on an inpatient team during clinical decision-making.

METHODS

We conducted a cross-sectional survey study at 6 institutions nationwide. We developed 3 complementary surveys adapted from prior research, 1 for each population: 200 hospitalists, 20 fellows, and 380 SRs. The instruments included questions about communication preferences between the SR, fellow, and hospitalist during clinical scenarios. We calculated univariate descriptive statistics and examined paired differences in percent agreement using χ2 tests, accounting for clustering by institution.

RESULTS

Response rates were: 53% hospitalists; 100% fellows; 39% SRs. Communication preferences varied based on role, scenario, and time of day. For most situations, hospitalists preferred more communication with the fellow overnight and when a patient or family is upset than expressed by fellows (P < .01). Hospitalists also desired more communication between the SR and fellow for an upset patient or family than SRs (P < .01), but all respondents agreed the SR should call the fellow for adverse events. More fellows and hospitalists felt that the SR should contact the fellow before placing a consult compared with SRs (95%, 86% vs 64%).

CONCLUSIONS

Hospitalists, fellows, and SRs may have differing preferences regarding communication, impacting supervision, autonomy, and patient safety. Training programs should consider such perspectives when creating expectations and communication guidelines.
Prediction Models for Intravenous Immunoglobulin Resistance in Kawasaki Disease: A Meta-analysis
Authors: Kuniyoshi Yasutaka , Tsujimoto Yasushi , Banno Masahiro , Taito Shunsuke , Ariie Takashi , Takahashi Natsuki , Tokutake Haruka , Takada Toshihiko
Published: April 2023

CONTEXT

Approximately 10% to 20% of patients with Kawasaki disease (KD) are refractory to initial intravenous immunoglobulin (IVIG) therapy. KD is mainly associated with coronary artery abnormalities.

OBJECTIVES

To identify and evaluate all developed prediction models for IVIG resistance in patients with KD and synthesize evidence from external validation studies that evaluated their predictive performances.

DATA SOURCES

PubMed Medline, Dialog Embase, the Cochrane Central Register of Controlled Trials, the World Health Organization International Clinical Trials Registry Platform, and ClinicalTrials.gov were searched from inception until October 5, 2021.

STUDY SELECTION

All cohort studies that reported patients diagnosed with KD who underwent an initial IVIG of 2 g/kg were selected.

DATA EXTRACTION

Study and patient characteristics and model performance measures. Two authors independently extracted data from the studies.

RESULTS

The Kobayashi, Egami, Sano, Formosa, and Harada scores were the only prediction models with 3 or more external validation of the161 model analyses in 48 studies. The summary C–statistics were 0.65 (95% confidence interval [CI]: 0.57–0.73), 0.63 (95% CI: 0.55–0.71), 0.58 (95% CI: 0.55–0.60), 0.50 (95% CI: 0.36–0.63), and 0.63 (95% CI: 0.44–0.78) for the Kobayashi, Egami, Sano, Formosa, and Harada models, respectively. All 5 models showed low positive predictive values (0.14–0.39) and high negative predictive values (0.85–0.92).

LIMITATIONS

Potential differences in the characteristics of the target population among studies and lack of assessment of calibrations.

CONCLUSIONS

None of the 5 prediction models with external validation accurately distinguished between patients with and without IVIG resistance.
Bész egy középkori zsoltároskönyvben. Képi források a kísértő ábrázolásához a Winchester Psalter illuminációjában (Cotton Ms Nero C. IV, f.18r)
Authors: Orosz Adrienn
Published: April 2023

ABSZTRAKT

Írásom az ördög egy kivételes ábrázolásáról szól, amely a híres román stílusú angliai kódex, a Winchester Psalter (Cotton MS Nero C. IV) 18. foliójának rectóján, a Jézus első kísértését ábrázoló jeleneten látható. Hogy megmagyarázzam, miért különleges ez az ábrázolás, összevetem a korabeli angliai készítésű kódexek kísértés-jeleneteinek ördögeivel, és azonosítom az alak inspirációs forrását, aki meglepő módon nem más, mint az ókori egyiptomi istenség, Bész. Megmagyarázom, hogyan lehetséges, hogy az illuminátor ismerte Bészt, milyen okok rejlenek a választás mögött, mit változtatott rajta, és miképp építette be az alakot a zsoltároskönyv ikonográfiai programjába.
Adalékok a Darkó–Moravcsik-vitához •
Authors: Mészáros Tamás
Published: April 2023

ABSZTRAKT

Darkó Jenő Laonikos Chalkokondylés szövegkiadásának megítélése már megjelenése óta vita tárgya. Bár annak idején a tudományos közvélemény jelentős része egyértelmű elismeréssel szólt Darkó munkájáról, a többség lelkesedését nem mindenki osztotta. A legélesebb, hasonló vitában már-már példátlanul kemény hangot éppen a fiatalabb honfi- és pályatárs, Moravcsik Gyula ütötte meg. Kettejük egyre inkább eldurvuló vitája nemzetközi nyilvánosságot is kapott. Ehhez a vitához kívánunk újabb adalékokkal szolgálni Franz Dölgernek, a Byzantinische Zeitschrift hajdani főszerkesztőjének tíz, Moravcsikhoz írt levelének bemutatásán keresztül.
Screening for Latent Polycythemia Vera in Renal Cell Carcinoma–Associated Erythrocytosis
Authors: Langabeer Stephen E.
Published: April 2023

N/A
Impacto de la pandemia por SARS-CoV2 en el índice de masa corporal de niños asistidos en la Ciudad Autónoma de Buenos Aires
Authors: Fenelli Gabriela Alejandra Sanluis , Tablado Manuel Rodríguez , Ferrero Fernando , Ossorio María Fabiana , Ferraro Mabel , Torres Fernando
Published: April 2023

Introducción: El sobrepeso y la obesidad infantil constituyen un problema de salud pública. El inicio de la pandemia por COVID-19 pudo haber favorecido esta patología. El puntaje Z del Índice Masa Corporal (Z-IMC) es un indicador aceptado para su diagnóstico y seguimiento. Objetivos: Evaluar si la prevalencia de sobrepeso y obesidad, y el Z-IMC en niños de 2 a 5 años aumentó durante la pandemia. Material y métodos: Estudio de cohorte retrospectiva. Se incluyeron pacientes asistidos en efectores públicos de salud del Gobierno de la Ciudad Autónoma de Buenos Aires (GCABA), de 2 a 4 años de edad, con registro de peso y talla en dos consultas, antes y después de haber comenzado el aislamiento social preventivo y obligatorio (ASPO). Se registró estado nutricional (Z-IMC) y variación del Z-IMC entre ambas consultas. Resultados: Se evaluaron 3866 sujetos, edad promedio 3,4±0,8 años; 48,1% mujeres. El intervalo promedio entre consultas fue 14,3±2,5 meses. La prevalencia de sobrepeso/obesidad aumentó de 12,6% IC95% 11,6-13,6 a. 20,9% IC95% 19,6-22-2; p<0,001, al igual que el Z-IMC (0,4±1,1 vs. 0,8±1,3; p <0,001). Conclusión: La prevalencia de sobrepeso y obesidad, y Z-IMC en niños de 2 a 5 años aumentó significativamente durante la pandemia.
Measuring Fairness Under Unawareness of Sensitive Attributes: A Quantification-Based Approach
Authors: Fabris Alessandro , Esuli Andrea , Moreo Alejandro , Sebastiani Fabrizio
Published: April 2023

Algorithms and models are increasingly deployed to inform decisions about people, inevitably affecting their lives. As a consequence, those in charge of developing these models must carefully evaluate their impact on different groups of people and favour group fairness, that is, ensure that groups determined by sensitive demographic attributes, such as race or sex, are not treated unjustly. To achieve this goal, the availability (awareness) of these demographic attributes to those evaluating the impact of these models is fundamental. Unfortunately, collecting and storing these attributes is often in conflict with industry practices and legislation on data minimisation and privacy. For this reason, it can be hard to measure the group fairness of trained models, even from within the companies developing them. In this work, we tackle the problem of measuring group fairness under unawareness of sensitive attributes, by using techniques from quantification, a supervised learning task concerned with directly providing group-level prevalence estimates (rather than individual-level class labels). We show that quantification approaches are particularly suited to tackle the fairness-under-unawareness problem, as they are robust to inevitable distribution shifts while at the same time decoupling the (desirable) objective of measuring group fairness from the (undesirable) side effect of allowing the inference of sensitive attributes of individuals. More in detail, we show that fairness under unawareness can be cast as a quantification problem and solved with proven methods from the quantification literature. We show that these methods outperform previous approaches to measure demographic parity in five experimental protocols, corresponding to important challenges that complicate the estimation of classifier fairness under unawareness.
COMPARATIVE STUDY ON THE COLLAPSE MODES UNDER FLASH-BOILING AND NON-FLASH-BOILING CONDITIONS USING A TWO-HOLE GDI INJECTOR
Authors: Li Yanfei , Zhao Zijie , Xing Enhui , Wang Zhongtao , Hong Haijun , Shuai Shijin
Published: April 2023

Several mechanisms are available for the multi-jet GDI spray collapse under low ambient pressure (≤ 1.0 bar) flash-boiling (LP-FB) and non-flash-boiling (NFB) conditions. The present investigation is to clarify the applicability of the available mechanisms under different thermodynamic states.
The tests were carried out in an optically accessible constant volume vessel using a two-hole GDI injector over fuel temperature (Tfuel) ranging from 50° to 130°C and ambient pressure (Pamb) ranging from 0.2 to 9.0 bar. The collapse could be found both under LP-FB and NFB conditions, but their characteristics changing with Pamb and Tfuel showed the opposite trends. The LP-FB collapse enhanced as Pamb decreased or Tfuel increased while the NFB collapse weakened as Pamb decreased and could disappear once Tfuel was beyond 70°C. Further analysis into the temporal spray development showed that the LP-FB collapse occurred at the very beginning of injection accompanied with the occurrence of a new jet between the original jets (termed as "inter-jet jet") while the NFB collapse gradually occurred with the time elapsed. The NFB collapse was attributed to the low-pressure
zone caused by the jet entrainment. The disappearance of NFB collapse as Tfuel increased demonstrated that the enhanced evaporation would counteract this low-pressure zone. This also provided the strong support that the LP-FB collapse could not be induced by the jet entrainment because the flashing evaporation was much stronger. After careful examination of the available mechanisms, it was more likely that the occurrence of under-expansion in LP-FB jets and their interactions at the nozzle exit caused the collapse.
Utilising under-burnt waste bricks from kilns as supplementary cementitious material
Authors: Mohan Mani , Singh Birendra Kumar
Published: April 2023

The pozzolanic performance of crushed brick powder (CBP), obtained by grinding under-burnt waste bricks from a continuous brick kiln, is studied. Two size fractions of CBP considered for cement replacement are CBP1 (passes through 150 μm but is retained on 75 μm) and CBP2 (passes through 75 μm). Compressive strength tests on mortar with CBP reveal that strength does not exceed that of the control; however, 10–15% cement replacement by CBP is the optimum. The presence of hydrate phases by X-ray diffraction and quantification of portlandite in the paste samples as studied by thermogravimetric analysis up to 90 days confirms the action of pozzolanicity. Furthermore, to determine the feasibility of CBP1 and CBP2 fractions in concrete, the strength and carbonation of M25 grade concrete were studied by replacing 45% cement with a combined proportion of CBP1 (20%) and CBP2 (25%). This reduced the concrete grade from M25 to M20 and increased the accelerated carbonation depth. Nevertheless, the projected natural carbonation coefficient with accelerated carbonation data is determined as low. The CBP used is cost-effective, requiring little mechanical processing and no chemical activation; thus it can satisfactorily be used for low-cost housing construction and lower-grade structural and non-structural uses.
Arsenic calamity in India’s West Bengal: a critical review of mitigation scenarios
Authors: Koley Soumyajit
Published: April 2023

Arsenic pollution of groundwater is a serious concern in the developing world. Over the last decade, significant progress has been made in arsenic remediation in India, where millions of households are exposed to arsenic poisoning through drinking water drawn from contaminated aquifers. Arsenic-treatment units (ATUs) have been effective in helping regions where piped-water supply of surface water is unachievable due to logistic constraints. However, no policy measure exists on environmental and economic management of the voluminous wastewater produced by ATUs. The waste is highly toxic in terms of its arsenic content and leachability and therefore can readily re-contaminate local environments if suitable stabilisation methods are not implemented. This paper presents an investigation of the recent developments in arsenic-wastewater-management practices of a severely affected state called West Bengal. Commercial fixation of the waste by incorporation into building materials is often seen as a potent method for ultimate encapsulation of arsenic toxicity. By analysing the practical efficacy of such a prospective project, the author has made an attempt to model scenarios involving non-hazardous and financially beneficial arsenic waste management for sustainable arsenic mitigation in the region.
Molecular MR Imaging of Renal Fibrogenesis in Mice
Authors: Chen Yin-Ching , Waghorn Philip A. , Rosales Ivy A. , Arora Gunisha , Erstad Derek J. , Rotile Nicholas J. , Jones Chloe M. , Ferreira Diego S. , Wei Lan , Martinez Robert V.P. , Schlerman Franklin J. , Wellen Jeremy , Fuchs Bryan C. , Colvin Robert B. , Ay Ilknur , Caravan Peter
Published: April 2023

Background

In most CKDs, lysyl oxidase oxidation of collagen forms allysine side chains, which then form stable crosslinks. We hypothesized that MRI with the allysine-targeted probe Gd-oxyamine (OA) could be used to measure this process and noninvasively detect renal fibrosis.

Methods

Two mouse models were used: hereditary nephritis in Col4a3-deficient mice (Alport model) and a glomerulonephritis model, nephrotoxic nephritis (NTN). MRI measured the difference in kidney relaxation rate, ΔR1, after intravenous Gd-OA administration. Renal tissue was collected for biochemical and histological analysis.

Results

ΔR1 was increased in the renal cortex of NTN mice and in both the cortex and the medulla of Alport mice. Ex vivo tissue analyses showed increased collagen and Gd-OA levels in fibrotic renal tissues and a high correlation between tissue collagen and ΔR1.

Conclusions

Magnetic resonance imaging using Gd-OA is potentially a valuable tool for detecting and staging renal fibrogenesis.
Human myocardium decellularization v2
Authors: Belviso Immacolata
Published: April 2023

The protocol represents a step-by-step method to obtain a decellularized cardiac matrix through the combination of sodium dodecyl sulphate (SDS) and Triton X-100. Briefly, cardiac samples obtained from left ventricles of explanted, pathological human hearts were dissected and washed to remove residual body fluids. Samples were then snap-frozen and sliced by a cryostat into 350 µm thick sections. The sections obtained were decellularized using a solution containing 1% Triton X-100 and 1% SDS in combination, for 24 hours, until observing the color change from brownish-red to translucent-white. As a result, the protocol shows efficiency in preserving extracellular matrix architecture and protein composition during the whole process, suggesting that it is worthwhile, highly reproducible and produces a well- preserved decellularized extracellular matrix from cardiac samples. (The last step contains a supplemental video with extra context and tips, as part of the protocols.io Spotlight series, featuring conversations with protocol authors.)
Heideggerian things. Perspectives about things and the practical occupation of Dasein in three periods of Heidegger's work (1927-1951)
Authors: Butierrez Luis Fernando
Published: April 2023

In the following work we will analyze and interpret three elaborations around the conceptions related to things, intramundane entities and the practical occupation of Dasein in the world, in three works corresponding to three moments of Heidegger's elaborations: the first, from the time of Sein und Zeit and the other two, to a transition period and after the Kehre. In this framework we intend to demonstrate and circumscribe the implications of the change in perspective in both periods, which move from the centrality given to the practical and functional field of Dasein, to a markedly relational approach that is radicalized in his 1951 writing. We will see, this distinction allows us to identify and relate a displacement of the emphasis in the manual model of primary relationship with the world and in the ethical projections that such treatments suppose.
Caballero Bonald: compromiso y rebeldía en los últimos libros de poemas
Authors: Jiménez Millán Antonio
Published: April 2023

El presente trabajo aborda el análisis de los últimos libros de poemas de José Manuel Caballero Bonald, desde Diario de Argónida (1997) hasta Desaprendizajes (2015). La obra poética de Caballero Bonald, desde sus inicios, surge de una indagación en el lenguaje que jamás pierde de vista la referencia central de la memoria; después de la publicación de Laberinto de Fortuna (1984) hay un margen de trece años hasta el siguiente libro, Diario de Argónida, que consolida un espacio mítico muy relevante en la obra del autor. Los dos siguientes libros, Manual de infractores (2005) y La noche no tiene paredes (2009) revelan distintas formas de disidencia y rebeldía frente a las políticas conservadoras, las consecuencias de la crisis económica y las guerras. El ciclo de senectud finaliza con dos libros, Entreguerras o de la naturaleza de las cosas (2012), otra versión de sus memorias, y Desaprendizajes (2015), donde se recupera el poema en prosa como vehículo expresivo.
Uso de anfotericina B liposomal en leishmaniasis cutánea diseminada causada por Leishmania braziliensis en un paciente pediátrico con síndrome de Down
Authors: Sandoval-Juárez Aidé , Rojas-Palomino Nyshon , Kolevic Roca Lenka , Pilares-Barco Graciela , Cuadros-Castro Jorge , Araujo-Castillo Roger
Published: April 2023

Se presenta un caso de leishmaniasis selvática cutánea diseminada con manifestación extensa en unapaciente pediátrica con síndrome de Down. El caso se confirmó a través de estudios parasitológicos einmunológicos, mientras que la identificación se realizó mediante la técnica de reacción en cadena dela polimerasa-polimorfismos de longitud de fragmentos de restricción (PCR-RFLP, por sus siglas eninglés), determinándose la especie como Leishmania (Viannia) braziliensis. La manifestación clínicaagresiva y prolongada con poca respuesta a estibogluconato y anfotericina desoxicolato pueden deberseal déficit inmunológico que se presenta como parte del síndrome de Down. La paciente eventualmenterecibió tratamiento con anfotericina B liposomal y al término de la terapia, mostró mejoría clínica de las lesiones. El presente reporte ilustra los desafíos tanto de diagnóstico como tratamiento de leishmaniasis cutánea en pacientes pediátricos inmunosuprimidos, especialmente en un entorno de difícil acceso social, económico y geográfico, a los servicios de salud. Se recomienda considerar a la leishmaniasis en el diagnóstico diferencial cuando se atienda ulceras crónicas dermatológicas atípicas; así como tener en cuenta el uso de anfotericina liposomal en pacientes inmunocomprometidos.
Contexto social e Inseguridad Alimentaria y Nutricional Moderada- Grave en familias con niños de 0 a 59 meses, Paraíba, Brasil, 2017- 2018
Authors: Figueroa-Pedraza Dixis
Published: April 2023

Objetivo. Analizar la asociación entre el contexto social (factores demográficos, socioeconómicos y soporte social) y la inseguridad alimentaria y nutricional moderada-grave de familias con niños de 0 a 59 meses matriculados en jardines infantiles municipales del estado de Paraíba, Brasil. Materiales y métodos. Estudio transversal desarrollado en municipios brasileños prioritarios para la prevención dela obesidad infantil. Se utilizó un cuestionario que recogió información sobre el contexto social de la familia (perfil demográfico del niño, situación socioeconómica y soporte social) y la escala brasileña de inseguridad alimentaria. La asociación entre las variables independientes y la inseguridad alimentaria y nutricional moderada-grave se determinó a través de una regresión de Poisson para estimar razones de prevalencia crudas y ajustadas, y sus respectivos intervalos de confianza al 95%. Resultados. De un total de 382 familias, el 27,2% presentaba inseguridad alimentaria y nutricional moderada-grave. Además, seencontró que aquellas familias con niños menores de 24 meses, de clases menos prósperas, beneficiadas del Programa Bolsa Família, sin apoyo social (material, emocional/informacional y de interacción) y disfuncionales tenían una mayor probabilidad de presentar el desenlace de estudio. Conclusiones. Los resultados del presente estudio indicaron que el 27,2% de las familias tenía inseguridad alimentaria y nutricional moderada-grave, siendo mayores en núcleos beneficiarios del Programa Bolsa Família, disfuncionales y sin apoyo social. En este sentido, la identificación de estos factores sería de utilidad paraoptimizar la seguridad alimentaria y nutricional familiar.
Aeromonas veronii biovar veronii Infection in Cultured European Seabass (Dicentrarchus labrax) in Türkiye
Authors: KARATAŞ STEINUM Süheyla , TURGAY Emre , YARDIMCI Remziye Eda , STEINUM Terje Marken
Published: April 2023

Fish in aquaculture systems are susceptible to infectious agents as they are kept in a densely populated and often physically restricted environment. Genus Aeromonas include well-known pathogens, and the member Aeromonas veronii has been reported to cause diseases in both humans and animals, either as primary infection or as mixed infection with other pathogens. This study describes a low mortality epizootic caused by Aeromonas veronii biovar veronii in European seabass (Dicentrarchus labrax) farmed in the Aegean Sea. The gills, kidneys and livers of moribund fish were pale. Erythema, haemorrhage and superficial ulcerative lesions were detected on the skin. In addition, petechial haemorrhage was observed on the tongue, maxilla, and operculum. The spleen was enlarged and multiple granulomas were detected in both the kidney and the spleen. Some fish had skin depigmentation, ecchymosis in the liver, and a bloody exudate in the abdominal cavity. The intestinal walls were lined with a clear yellowish fluid. Twenty-nine motile, Gram-negative bacterial isolates were obtained from the internal organs of diseased fish. According to morphology, biochemical properties and 16S rRNA gene sequencing results, all isolates were identified as Aeromonas veronii bv. veronii. All isolates were resistant to amoxicillin and ampicillin, and sensitive to oxytetracycline, enrofloxacin, ciprofloxacin, florfenicol, and flumequine.
Access to Information Law in Brazil: what the implementation data reveal
Authors: Capuano Ethel Airton
Published: April 2023

This article shows the results of a research to evaluate the implementation process of the Access to Information Law in the Brazilian Federal Government using empirical data on the level of user satisfaction published since 2013 until 2020 by the Office of the Comptroller General in its computing system available in the Internet. The main goal of the research was to contribute to a revival of this complex issue for democracy in a sense of reality, using a twofold methodology axis: (i) analysis of an empirical and significant data sample collected from the system with statistics techniques, and (ii) logic assessment of the resulting statistics parameters based in the Expectancy-Disconfirmation Theory. The empirical data about operational process to implement the law revealed, in one hand, that federal agencies and state-owned companies have evolved to improve the access to information and nowadays Brazilian Federal Government’s performance is in a relatively good position amongst developed and developing countries, with some government bodies achieving high rates of access to information granted to the requester citizens, but, in another hand, also revealed that in some areas of government there is still need of a broad communication to the citizens about the scope of the law. Other important conclusion is that an adequate computing system to implement the access to information is a sine qua non requirement to a steady advance beyond the approval of an Access to Information Law.
Knee replacement surgery is more precise with
Authors: Munot Shreepal , Saraf Hrushikesh
Published: April 2023

Robotic assisted total knee arthroplasty is one the recent advance to improve its outcome especially to address the issue of precision. Longetivity of TKA primarily depends on proper implant alignment. The Aim of this study is to compare the precision of robotic assisted TKA with the ideally planned mechanical parameters in TKA.

A total of 50 robotic assisted TKA patients were included retrospectively in the study. Patient’s post operative mechanical femorotibial angle (mFTA), Lateral distal femoral angle (LDFA), medial proximal tibial angle (mPTA) in AP radiogram.and anterior femoral offset ratio, posterior condylar offset ratio, femoral component flexion, posterior tibial slope in lateral radiograms were evaluated with ideal values for specific parameter. Number of outliers were counted separately with values beyond 3 of malalignment.

The mean postoperative FTA, LDFA, mPTA recorded is 0.15 ±0.70, 89.78±0.79, 89.80±0.86 respectively. The mean postoperative posterior tibial slope, femoral flexion is 3.03±0.35, 3.14±0.60 respectively. All the parameters when compared with planned ideal values (i.e. mFTA= 0, mPTA=90, LDFA=90, Posterior tibial slope=3, femoral component flexion=3) did not show significant difference.

Study shows promising results with near normal execution of planned TKA. Robotic assisted TKA can be a game changer and a handy tool to improve the alignment of mechanical axis in TKAs.
Subtalar joint dislocation: An uncommon injury, revisited
Authors: Vernekar Anish , Krishnamoorthi Arun , Bandekar S M
Published: April 2023

Subtalar joint dislocations are very uncommon and occur following high energy injury, usually following motor vehicular accidents. They account for around 1-2% of dislocations. We present to you, a few cases of subtalar joint dislocation managed initially by closed reduction, followed by open reduction under anesthesia, with excellent functional outcome. Close to fifty percent of patients suffering from complicated injury, are frequently at risk of developing complications. Avascular necrosis of the talus is the most common complication, following dislocation. Other long-term sequelae include osteochondral fracture and subtalar joint instability. This study is presented because of its rarity in clinical practice.
Scapular Caffey’s disease: A masquerading swelling in an infant, a case report and review of literature
Authors: Khan Ozair S , Kumar V A Senthil , Gupta Tapisha
Published: April 2023

Caffey’s disease was characterized by a triad of symptoms, irritability, soft tissue swelling, and underlying cortical bone thickening. It mostly occurs before the first 5 months of life in infancy. The knowledge of this pathology was essential as it masquerades as wide range diseases including acute osteomyelitis, bone tumors, trauma, battered baby syndrome (child abuse), hypervitaminosis a, scurvy, infantile malignant osteopetrosis, neonatal tuberculosis, congenital syphilis, pseudoparalyis of infancy which was more common and require specific management including extensive surgery. Classically, infantile cortical hyperostosis disease occurs in the early part of the first year of life. Infantile cortical hyperostosis was characterized by a clinical triad (fever, soft-tissue swelling, hyperirritability) and a clinching radiographic picture of underlying cortical hyperostosis (thickening or bony expansion). We reported a case of scapular swelling in a 2 -month-old infant where a retrospective diagnosis of caffey’s disease was made. We proposed a high clinical suspicion for early diagnosis of Caffey’s disease and hence appropriate management.
Low-parameter method for delineation of agricultural fields in satellite images based on multi-temporal MSAVI2 data
Authors:   Institute for Information Transmission Problems, RAS, Pavlova M.A. , Timofeev V.A. ,   Institute for Information Transmission Problems, RAS, Bocharov D.A. ,   Institute for Information Transmission Problems, RAS, Sidorchuk D.S. ,   Institute for Information Transmission Problems, RAS, Nurmukhametov A.L. ,   Institute for Information Transmission Problems, RAS, Nikonorov A.V. ,   IPSI RAS – Branch of the FSRC “Crystallography and Photonics” RAS,   Samara National Research University, Yarykina M.S. ,   Institute for Information Transmission Problems, RAS, Kunina I.A. ,   Institute for Information Transmission Problems, RAS, Smagina A.A. ,   Institute for Information Transmission Problems, RAS, Zagarev M.A. ,   Institute for Information Transmission Problems, RAS
Published: April 2023

This paper considers an issue of delineating agricultural fields in satellite images. In this task we follow a multi-temporal data approach. We show that on such data, good quality can be achieved using a simple low-parameter method. The method consists of a combination of a field detector and an edge detector. The field detection is based on an Otsu thresholding technique and for the edge detection we use a Canny detector. Facing a lack of available datasets and aiming to estimate the proposed algorithm, we prepared and published our dataset consisting of 18,859 expertly annotated fields using Sentinel-2 data. We implement one of the state-of-the-art deep-learning approaches and compare it with the proposed method on our dataset. The experiment shows the proposed simple multi-temporal algorithm to outperform the state-of-the-art instant data approach. This result confirms the importance of using multi-temporal data and for the first time demonstrates that the delineation problem can be solved at a lower cost without loss of quality. Our approach requires a significantly less amount of training data when compared with the NN-based one. The dataset of agricultural fields used in the work and the proposed algorithm implementation in Python are published in open access.
Variation in the shell elements of Chrysemys picta bellii (Gray 1831)
Authors: Corsini Joseph
Published: April 2023

Variation in the Shell Elements of Chrysemys picta bellii (Gray 1831)
Assignment of fossil turtle shell elements to a specific taxon is often difficult because the range of variation within the population is usually not well characterized. In addition, it is sometimes not clear whether the fossil forms actually differ from their extant counterparts because often the range of shell element variation in modern species has not been determined. The emydid turtles are no exception, with confusion often arising in the identification of isolated fossil elements and sometimes intact shells representing Emys, Pseudemys, Malaclemys, and Graptemys, as well as the deirochelyids Chrysemys,  Clemmys, Deirochelys, and Trachemys. In order to begin providing a database with modern counterparts of the deirochelyid turtles, I have photographed and illustrated seven extant Chrysemys picta bellii shells, six of which were collected at a single pond in Nebraska and one from Ladd Marsh in Union County, Oregon . Photographs and detailed illustrations indicate a broad range in the shapes of many characters.  Side by side comparisons of some key elements show that there is significant variation in several important characters (nuchal shape/sulci, entoplastron shape/sulci, and pygal shape/sulci). I also conducted a limited morphometric analysis of several sulcus/suture distance ratios, showing substantial variation between individuals in some cases. Covariance and correlation analysis of this variation suggests that allometry is not involved in most cases. In summary, this work provides a visual and morphometric dataset for aid in identifying and assigning shell elements of fossil emydid turtles.
Severity of SARS-CoV-2 reinfection in vaccinated healthcare workers
Authors: Golshahi Fatemeh , Siami Zeinab , Feizabad Elham , Rajabzadeh Shahab , Zarinjooie Shirin , Albaji Maryam , Mabadi Avin , Azarnoush Ayein , Nazemi Pershang
Published: April 2023

Background and Objectives: The most appropriate approach to control the SARS-CoV-2 epidemic is the widespread adop- tion of vaccination. Several vaccines against SARS-CoV-2 have been developed and authorized for use in various geo- graphical regions. The aim of this study is to evaluate the efficacy of the vaccination agents presently utilized by healthcare workers (HCWs), and to investigate whether different COVID-19 vaccines would result in the alleviation of symptoms and the severity of clinical presentation.
Materials and Methods: This multi-center survey was conducted on 329 vaccinated HCWs who were reinfected with COVID-19 between January 8, 2021 and April 8, 2021, in Tehran, Iran.
Results: Overall, 92.1% and 70.8% of the participants had received 2 and 3 cumulative doses of COVID-19 vaccines, respectively. There were no differences between first/second and third-dose vaccines with the severity of SARS-CoV-2 in- fection. Expectedly, vaccination resulted in a less severe clinical presentation of SARS-CoV-2 infection, as reported by the participants.
Conclusion: The results suggest that the efficacy of the vaccination agents presently utilized by HCWs was acceptable with no significant difference in vaccine type. Participants receiving at least two doses of vaccines in this survey exceeded 90%, which is comparably higher than studies conducted in other countries.