bluuebunny/crossref_metadata_2025 huggingface dataset:
NALCN‐mediated sodium influx confers metastatic prostate cancer cell invasiveness
Authors: Folcher Antoine , Gordienko Dmitri , Iamshanova Oksana , Bokhobza Alexandre , Shapovalov George , Kannancheri‐Puthooru Dheeraj , Mariot Pascal , Allart Laurent , Desruelles Emilie , Spriet Corentin , Diez Raquel , Oullier Thibauld , Marionneau‐Lambot Séverine , Brisson Lucie , Geraci Sandra , Impheng Hathaichanok , Lehen'kyi V'yacheslav , Haustrate Aurélien , Mihalache Adriana , Gosset Pierre , Chadet Stéphanie , Retif Stéphanie , Laube Maryline , Sobilo Julien , Lerondel Stéphanie , Villari Giulia , Serini Guido , Pla Alessandra Fiorio , Roger Sébastien , Fromont‐Hankard Gaelle , Djamgoz Mustafa , Clezardin Philippe , Monteil Arnaud , Prevarskaya Natalia
Published: June 2023

There is growing evidence that ion channels are critically involved in cancer cell invasiveness and metastasis. However, the molecular mechanisms of ion signaling promoting cancer behavior are poorly understood and the complexity of the underlying remodeling during metastasis remains to be explored. Here, using a variety of in vitro and in vivo techniques, we show that metastatic prostate cancer cells acquire a specific Na+/Ca2+ signature required for persistent invasion. We identify the Na+ leak channel, NALCN, which is overexpressed in metastatic prostate cancer, as a major initiator and regulator of Ca2+ oscillations required for invadopodia formation. Indeed, NALCN‐mediated Na+ influx into cancer cells maintains intracellular Ca2+ oscillations via a specific chain of ion transport proteins including plasmalemmal and mitochondrial Na+/Ca2+ exchangers, SERCA and store‐operated channels. This signaling cascade promotes activity of the NACLN‐colocalized proto‐oncogene Src kinase, actin remodeling and secretion of proteolytic enzymes, thus increasing cancer cell invasive potential and metastatic lesions in vivo. Overall, our findings provide new insights into an ion signaling pathway specific for metastatic cells where NALCN acts as persistent invasion controller.
Optimising prednisolone or prednisone replacement in adrenal insufficiency
Authors: Sharma Angelica , Lazarus Katharine , Papadopoulou Deborah , Prabhudev Hemanth , Tan Tricia , Meeran Karim , Choudhury Sirazum
Published: June 2023

Context

Patients with adrenal insufficiency (AI) have a higher mortality than the general population, possibly because of excess glucocorticoid exposure at inappropriate times. The cortisol circadian rhythm is difficult to mimic with twice- or thrice-daily hydrocortisone. Prednisolone is a once-daily alternative which may improve patient compliance through its convenience.

Objectives

Prednisolone day curves can be used to accurately downtitrate patients to the minimum effective dose. This study aimed to review prednisolone day curves and determine therapeutic ranges at different time points after administration.

Methods

Between August 2013 and May 2021, 108 prednisolone day curves from 76 individuals receiving prednisolone replacement were analysed. Prednisolone concentrations were determined by ultra-high-performance liquid chromatography-tandem mass spectrometry. Spearman’s correlation coefficient was used to determine the relationship between 2-, 4-, and 6-h prednisolone levels compared to the previously validated standard 8-h prednisolone level (15–25 μg/L).

Results

The median dose was 4 mg of prednisolone once daily. There was a strong correlation between the 4- and 8-h (R = 0.8829, P ≤ 0.0001) and 6- and 8-h prednisolone levels (R = 0.9530, P ≤ 0.0001). Target ranges for prednisolone were 37–62 μg/L at 4 h, 24–39 μg/L at 6 h, and 15–25 μg/L at 8 h. Prednisolone doses were successfully reduced in 21 individuals, and of these, 3 were reduced to 2 mg once daily. All patients were well upon follow-up.

Conclusion

This is the largest evaluation of oral prednisolone pharmacokinetics in humans. Low-dose prednisolone of 2–4 mg is safe and effective in most patients with AI. Doses can be titrated with either 4-, 6-, or 8-h single time point drug levels.
Orthopaedic applications of cold physical plasma
Authors: Nonnenmacher Lars , Fischer Maximilian , Haralambiev Lyubomir , Bekeschus Sander , Schulze Frank , Wassilew Georgi I , Schoon Janosch , Reichert Johannes C
Published: June 2023

Cold physical plasma (CPP) technology is of high promise for various medical applications.

The interplay of specific components of physical plasma with living cells, tissues and organs on a structural and functional level is of paramount interest with the aim to induce therapeutic effects in a controlled and replicable fashion.

In contrast to other medical disciplines such as dermatology and oromaxillofacial surgery, research reports on CPP application in orthopaedics are scarce.

The present implementation of CPP in orthopaedics involves surface modifications of orthopaedic materials and biomaterials to optimize osseointegration. In addition, the influence of CPP on musculoskeletal cells and tissues is a focus of research, including possible adverse reactions and side effects. Its bactericidal aspects make CPP an attractive supplement to current treatment regimens in case of microbial inflammations such as periprosthetic joint infections. Attributed anticancerogenic and pro-apoptotic effects underline the clinical relevance of CPP as an additive in treating malignant bone lesions.

The present review outlines ongoing research in orthopaedics involving CPP; it distinguishes considerations for safe application and the need for more evidence-based research to facilitate robust clinical implementation.
Upper limb and lower limb radiofrequency treatments in orthopaedics
Authors: Rodríguez-Merchán E Carlos , Delgado-Martínez Alberto D , De Andrés-Ares Javier
Published: June 2023

Radiofrequency (RF) is a minimally invasive technique for disrupting or altering nociceptive pathways to treat musculoskeletal neuropathic and nociplastic pain.

RF has been employed to treat painful shoulder, lateral epicondylitis, knee and hip osteoarthritis, chronic knee pain, Perthes disease, greater trochanteric pain syndrome, plantar fasciitis, and painful stump neuromas; it has also been employed before and after painful total knee arthroplasty and after anterior cruciate ligament reconstruction.

The benefits of RF include the following:it is safer than surgery; there is no need for general anaesthesia, thereby reducing adverse effects; it alleviates pain for a minimum of 3–4 months; it can be repeatable if necessary; and it improves joint function and minimizes the need for oral pain medication.

RF is contraindicated for pregnant women; unstable joints (hip, knee, and shoulder); uncontrolled diabetes mellitus; presence of an implanted defibrillator; and chronic joint infection (hip, knee, and shoulder).

Although adverse events from RF are unusual, potential complications can include infection, bleeding, numbness or dysesthesia, increased pain at the procedural site, deafferentation effect, and Charcot joint neuropathy.

Although there is a risk of damaging non-targeted neural tissue and other structures, this can be mitigated by performing the technique under imaging guidance (fluoroscopy, ultrasonography, and computed tomography).

RF appears to be a valuable technique for alleviating chronic pain syndromes; however, firm proof of the technique’s efficacy is still required.

RF is a promising technique for managing chronic musculoskeletal of the limbs pain, particularly when other techniques are futile or not possible.
Tranexamic acid-induced focal convulsions after spinal surgery: a rare case report and literature review on side effects of accidental spinal administration of tranexamic acid
Authors: Luo Hua , Shen Chaojun , Qu Tongyou , Chen Lin , Sun Yue , Ren Yu
Published: June 2023

Convulsions are a neurological illness that has complexity. In clinical treatment, drug-induced convulsions appear from time to time. Drug-induced convulsions often begin as isolated acute seizures but may progress to persistent seizures. In orthopedics, topical administration of tranexamic acid is commonly used in conjunction with intravenous drip to achieve hemostasis during artificial joint replacement surgery. However, side effects induced by tranexamic acid accidental spinal administration should be taken seriously.

We report a case of a middle-aged male treated with tranexamic acid locally in combination with intravenous drip for intraoperative hemostasis when undergoing spinal surgery. The patient had involuntary convulsions in both lower limbs after the operation. After symptomatic administration, the symptoms of convulsions gradually resolved. During the follow-up, the convulsions never occurred again. We reviewed the literature on cases with side effects of local tranexamic acid application in spinal surgery and discussed the mechanism of tranexamic acid-induced convulsions.

Tranexamic acid is associated with an increased incidence of postoperative seizures. However, many clinicians are unaware that tranexamic acid causes seizures. This rare case summarized the risk factors and clinical features of these seizures. Moreover, it highlights several clinical and preclinical studies that offer mechanistic insights into the potential causes and treatments for tranexamic acid-associated seizures. A clear understanding of tranexamic acid-induced convulsions-related adverse reactions can help the first-line clinical screening of causes and adjustment of drug treatment. This review will aid the medical community by increasing awareness about tranexamic acid-associated seizures and translating scientific findings into therapeutic interventions for patients.
Do prior intra-articular injections impact on the risk of periprosthetic joint infection in patients undergoing total hip arthroplasty? A meta-analysis of the current evidences with a focus on the timing of injection before surgery
Authors: Saracco Michela , Ciriello Vincenzo , D’Angelo Fabio , Zagra Luigi , Solarino Giuseppe , Logroscino Giandomenico
Published: June 2023

Purpose

Intra-articular injection is a well-established and increasingly used treatment for the patient with mild-to-moderate hip osteoarthritis. The objectives of this literature review and meta-analysis are to evaluate the effect of prior intra-articular injections on the risk of periprosthetic joint infection (PJI) in patients undergoing total hip arthroplasty (THA) and to try to identify which is the minimum waiting time between hip injection and replacement in order to reduce the risk of infection.

Methods

The database of PubMed, Embase, Google Scholar and Cochrane Library was systematically and independently searched, according to Preferred Reporting Items for Systematic Reviews and Meta–Analyses (PRISMA) guidelines. To assess the potential risk of bias and the applicability of the evidence found in the primary studies to the review, the Newcastle–Ottawa scale (NOS) was used. The statistical analysis was performed by using the software ’R’ version 4.2.2.

Results

The pooling of data revealed an increased risk of PJI in the injection group that was statistically significative (P = 0.0427). In the attempt to identify a ’safe time interval’ between the injection and the elective surgery, we conducted a further subgroup analysis: in the subgroup 0–3 months, we noted an increased risk of PJI after injection.

Conclusions

Intra-articular injection is a procedure that may increase the risk of developing periprosthetic infection. This risk is higher if the injection is performed less than 3 months before hip replacement.
Comparison of Cobb angle measurements for scoliosis assessment using different imaging modalities: a systematic review
Authors: d'Astorg Henri , Bourret Stephane , Ramos-Pascual Sonia , Szadkowski Marc , Le Huec Jean-Charles
Published: June 2023

Purpose

To report accuracy, repeatability, and agreement of Cobb angle measurements on radiographs and/or stereo-radiographs (EOS) compared against one another or against other imaging modalities.

Methods

This review follows Preferred Reporting Items for Systematic Reviews and Meta-analysis (PRISMA) guidelines. A literature search was conducted on 21 July 2021 using Medline, Embase, and Cochrane. Two researchers independently performed title/abstract/full-text screening and data extraction. Studies were eligible if they reported Cobb angles, and/or their repeatability and agreement, measured on radiographs and/or EOS compared against one another or against other imaging modalities.

Results

Of the 2993 records identified, 845 were duplicates and 2212 were excluded during title/abstract/full-text screening. Two more relevant studies were identified from references of eligible studies, leaving 14 studies for inclusion. Two studies compared Cobb angles from EOS vs CT, while 12 compared radiographs vs other imaging modalities: EOS, CT, MRI, digital fluoroscopy, or dual-energy x-ray absorptiometry. Angles from standing radiographs tended to be higher than those from supine MRI and CT, and angles from standing EOS tended to be higher than those from supine or prone CT. Correlations across modalities were strong (R = 0.78–0.97). Inter-observer agreement was excellent for all studies (ICC = 0.77–1.00), except one (ICC = 0.13 radiographs and ICC = 0.68 for MRI).

Conclusion

Differences of up to 11º were found when comparing Cobb angles across combinations of imaging modalities and patient positions. It is not possible, however, to determine whether the differences observed are due to the change of modality, position, or both. Therefore, clinicians should be careful when utilizing the thresholds for standing radiographs across other modalities and positions for diagnosis and assessment of scoliosis.
Priming and cross-adaptation of plants to abiotic stresses: state of the problem and prospects
Authors:   Institute of Plant Physiology and Genetics, National Academy of Sciences of Ukraine 31/17 Vasylkivska St., Kyiv, 03022, Ukraine, Kiriziy D.A.
Published: June 2023

The review is devoted to the current state and prospects of research on the problem of plants priming and cross-adaptation to abiotic stress factors — mainly drought and high temperature. These studies are becoming increasingly relevant due to global climate change, as they reveal new approaches to increasing the crops resistance to stressors. The key link in this case is the formation of the so-called stress memory (priming) under the influence of moderate stress, which allows the plant to activate protective mechanisms faster and more effectively under the effect of the next harder stress of the same or a different nature (cross-adaptation) and thereby mitigate its impact compared to non-primed plants. In this regard, information on signaling systems that participate in the perception of a stress factor by a plant and trigger protective mechanisms through multi-cascade networks is considered. The results of experiments on priming plants with high temperature or drought at the beginning of the growing season to the action of these stressors at later development stages, as well as examples of cross-adaptation, when priming with drought increased thermotolerance and vice versa, are given. Possible mechanisms of stress memory formation and retention within one generation and its transference to subsequent generations (transgenerational stress memory) are briefly considered. At the same time, one of the unsolved problems remains the correctness of extrapolation results obtained in laboratory or controlled conditions to the practice of growing plants in the field. Certain side effects of priming should also be considered, as priming may cause some negative effects on plant physiology and productivity. Therefore, it is necessary to test whether the primed plants will perform as well as the control if the stress will not happen.
A Survey of Drug-coated Balloon Usage Patterns in the Asia-Pacific Region
Authors: Ang An Shing , Li Cliff KF , Tan Jack Wei Chieh , Ong Paul JL
Published: June 2023

Background: Drug-coated balloon (DCB) therapy has been shown to be an effective alternative to drug-eluting stents as a revascularisation option, but usage of DCB varies widely between different countries. The aim of this study was to review the awareness of the DCB expert consensus paper and the prevalence of DCB usage among interventionists in the Asia-Pacific region. Methods: An online questionnaire was designed to explore the awareness of the DCB expert consensus paper and evaluate the prevalence of DCB usage. This was sent to interventional cardiologists in collaboration with the Asian Pacific Society of Cardiology. Results: The total number of respondents was 237. Slightly more than half were unaware of the DCB expert consensus paper, and the majority use fewer than 10 DCBs per month. Statistical analysis showed that awareness of the DCB expert consensus paper had a positive correlation with increased DCB usage when treating patients with high bleeding risk, bifurcation disease and small vessel disease, while increased frequency of DCB usage was positively correlated with the treatment of patients with high bleeding risk and small vessel disease. However, these two factors were not significantly associated with the increased use of DCB to treat in-stent restenosis. Conclusion: With emerging data expanding the indications for DCB and increasing operator experience, DCB usage is likely to become more commonplace during percutaneous coronary intervention.
Decarbonization challenges and opportunities in the Central European energy sector: Implications for management
Authors: Magyari József
Published: June 2023

While decarbonization and hydrogen energy are at the top of European policymakers' agenda, research and innovation (R&I) management of energy companies must focus on clean technologies (cleantech) which could decrease greenhouse gas (GHG) emissions in the sector. The Central European energy sector, however, might face a decarbonization challenge because of the specific geopolitical situation, so aligning R&I directions with regional policy and conditions seem to be crucial to accelerate sectoral and corporate adaptation. This study focuses on the decarbonization progress and strategies of the Visegrád 4 (V4) countries, concerning some of the most promising hydrogen-driven cleantech R&I directions which might induce strategic changes in Central European energy companies. Besides promoting renewable energy sources, results show that V4 strategies usually include the development of nuclear energy capacities to reduce GHG emissions and using the extended natural gas infrastructure for renewable energy storage. The analysed cleantech innovations are included but usually not central in these strategies. Strategic changes in energy companies, however, could be driven by these promising R&I directions, e.g., the hydrogen economy development by power-to-X (P2X) technologies, industrial decarbonization by carbon capture, utilization or storage (CCUS) technologies in the mid-term, and cross-sectoral integration and optimization by smart energy system (SES) development in the long-term.
Lateral-torsional buckling resistance of corrugated web girders
Authors: Bärnkopf Erzsébet , Jáger Bence , Kövesdi Balázs
Published: June 2023

There is currently no accurate calculation procedure for determining the lateral-torsional buckling resistance of trapezoidally corrugated web girders. Therefore, a detailed investigation is performed in the frame of an experimental and numerical research program at the Department of Structural Engineering of the Budapest University of Technology and Economics. Based on the previous experimental results, a numerical model is developed to be used to determine the lateral-torsional buckling resistance by using deterministic method. The effect of flange size, corrugation geometry and boundary conditions are investigated. An improved design method is developed for the determination of the lateral-torsional buckling resistance of trapezoidally corrugated web girders.
Hz. Muhammed’in Sesinin Güzelliğine Dair Rivâyetler Üzerine Bir İnceleme
Authors: KOCA Fatih
Published: June 2023

Güzellik kavramı mahiyeti itibarıyla göreceli olmakla birlikte güzel ses, insanlığın genel olarak ortak paydada buluştuğu bir yetenektir. Bu yetenek, insanlarda değişken düzeyde de olsa mevcuttur. Her yeteneğin eğitime ve gelişime ihtiyaç duyduğu gibi güzel ses de ayırt edilmeye, eğitilmeye, geliştirilmeye ve taltif edilmeye ihtiyaç duyar. Bu sayede güzel yaratılan insan, ses bakımından da güzele ulaşabilmelidir. Ortaya çıkan bu güzellik, insanlar üzerine dinî duyguların güçlendirilmesi yönünde bir etkiye de sahiptir. Bu yüzden insanlara yol gösterici olarak gönderilen peygamberler de tebliğlerinde mûsikînin bu etkisinden yararlanmışlardır. Hatta bazı peygamberler güzel sesi bir tebliğ yöntemi olarak kullanmalarıyla öne çıkmışlardır. Güçlü hitabet yeteneği ile güzel sesi tebliğ metodunun bir parçası hâlinde kullanan peygamberlerin son temsilcisi olarak Hz. Muhammed’in de hem kendinin güzel sesli olması hem de güzel sese verdiği ehemmiyet dikkate değerdir. Hz. Muhammed’in gerek kendinden önceki peygamberler hakkında vermiş olduğu bilgiler gerekse yaşadığı dönemin şartları itibarıyla güzel sesi merkeze alması önem arz eden başlıca konulardandır. Bu çalışmada Peygamberlerin seslerine dair hadis rivayetleri ile Hz. Peygamber’in sesinin güzelliği ve dinleyenler üzerindeki tesirine dair nakiller değerlendirilecektir. Ayrıca Hz. Peygamber’in güzel ses konusundaki tutumu ile “Hz. Peygember’in sesi” hakkında Kur’ân-ı Kerîm ayetleri ve hadis-i şerif rivayetleri arasında yer alan bilgiler, dönemin şartlarına uygun olarak mûsikî açısından incelenecektir.
DEVELOPMENT OF WORKSTATION FOR THE ROAD MASTER ON THE TRACK DISTANCE
Authors: Bieltiukov V. P.
Published: June 2023

The functions, task and the requirements showed to a subsystem, the automated workplace of the roadman of a distance of a way are determined in the article.
SIMULATION OF PROTECTION OF THE AIR ENVIRONMENT FROM POLLUTION BY AMMONIA WITH LIQUID CURTAINS
Authors: Biliaiev M. M. , Koptilaia O. V.
Published: June 2023

A computer model to simulate the ammonia cloud concentration reduction with sprinklers which used water or acid was developed. The model is based on 3D equation of admixture transfer written both for ammonia and neutralizator. The results of numerical experiment are presented.
MATHEMATICAL MODELING OF RIVER POLLUTION IN CASE OF THE TANKS RUN OFF THE RAILS
Authors: Biliaiev M. M. , Zyonh N. S.
Published: June 2023

A mathematical model to calculate pollution of the Rivers Dnipro and Samara after an emergency discharge of a pollutant has been developed. The model is based on 2D equations of annual river hydraulics and the impurity transfer equation. The results of numeral simulation of pollution of the rivers’ area after derailment of railtanks from the bridge are presented.
JOINT CALCULATION OF ANGLED RETAINING WALL AND GROUND PROTECTION FROM THE KINETIC EXCITEMENT
Authors: Hrishyn O. V. , Savchynskyi B. V.
Published: June 2023

The article offers the procedure and programmatic complex for joint calculation of a breast wall and soil massif as a unified conjunct dynamic system. The novelty of task consists in the fact that in its study the theory of plastic flow with consolidation has been used for the first time. Such statement of the problem enables to elaborate in the future a new approach to calculation of seismic-resistant facilities.
DEVELOPMENT OF THE METHOD OF OPTIMUM ADJUSTMENT AREAS FOR THE ORGANIZATION OF HIGH-SPEED RAILWAY TRAINS
Authors: Kurhan M. B.
Published: June 2023

The proposed optimization method is based on usage of a non-additive function of cutting the train running time upon sections (facilities), subject to reconstruction. The effect in the optimization procedure is being reached thanks to introduction of new semi-additive (from bottom and from top) functions, which reduces the optimization time in comparison with linear search of the options.
JUSTIFICATION OF SCIENTIFIC FIELDS OF SOIL MECHANICS WITH INCREASING THE SPEED OF RAILWAY ROLLING STOCK
Authors: Kostiuk M. D. , Pshinko O. M. , Petrenko V. D. , Tsepak S. V.
Published: June 2023

Comparative calculations of earthen railway bed have been performed and regularities of the influence of loading onto change of strains have been determined.
THE ANALYSIS OF REFORMING OF STRUCTURES OF RAILWAY TRANSPORT MANAGEMENT IN THE DEVELOPED COUNTRIES OF EUROPE
Authors: Barash Yu. S.
Published: June 2023

The article analyzes intermediate results of reforming the structures of railway transport management in developed European countries after adoption of the European Union’s declarations on the issue. The conclusion has been made that the governments of European countries have different attitudes toward the EU directives and do not always consider it necessary to reform the structure of railway transport management.
THE PACE OF REFORM MANAGEMENT SYSTEM ON THE RAILWAYS OF SOME COUNTRIES IN THE WORLD
Authors: Teslenko T. V.
Published: June 2023

The contents of the article envisage an analysis of the rates of railway transport managerial structures reformation in Germany, Poland and Russia.
DYNAMICS OF HIGH-SPEED ELECTRIC LOCOMOTIVE TYPE DS3
Authors: Blokhin Ye. P. , Pshinko O. M. , Korotenko M. L. , Hranovskyi R. B. , Harkavi N. Ya. , Dzychkovskyi E. M.
Published: June 2023

In paper results of dynamics tests of electric locomotive DS3 are submitted
DIAGNOSTICS OF RUNNING GEAR OF RAIL VEHICLES IN MOTION
Authors: Bohomaz H. I. , Kovtun Ye. M. , Markova O. M. , Malyi V. V. , Raznosilin V. V.
Published: June 2023

The possibility of estimating the technical state of railway vehicle running gears by their dynamic characteristics obtained during train motion with the help of developed diagnostic system is considered in the paper.
GENERALISATION OF LEARNED LESSONS IN DESIGN OF FREIGYT CARS TRUCKS FOR THE CREATION OF THEIR STANDARD SERIES
Authors: Boronenko Yu. P. , Orlova O. M.
Published: June 2023

The paper generalizes experience of the latest scientific and practical developments in the field of freight bogies that can be implemented in the type series. Bogie types are split into classes by design speed, and technical solutions for each type are provided. The series also contains three types of groups with different axle loads. Scientific and design problems that are still to be solved are formulated.
THE METHODOLOGY AND RESULTS COMPARISON OF OPERATION QUALITY OF HYDRAULIC SHOCK ABSORBERS OF CENTRAL SUSPENSION THE PASSENGER CARS BY THE RESULTS OF TESTS ON THE LINE
Authors: Boronenko Yu. P. , Orlova O. M. , Bielhorodtseva T. M.
Published: June 2023

Performance testing of passenger coaches equipped with different types of hydraulic dampers in secondary suspension which allowed determining characteristic frequencies, deformation velocities and resistance forces was carried out. Generalized criteria were proposed to compare dampers according to the ride qualities. Recommendations towards changing the requirements to the dampers and their rig testing methods are given.
THE INFLUENCE OF HUMAN FACTOR ON TRAFFIC SAFETY
Authors: Vaichiunas H.
Published: June 2023

Problems of the influence of the locomotive driver working time length on the safety of railway trains motion are considered in the paper.
ANALYSIS OF THE INFLUENCE OF ROLL SURFACE PROFILE ON THE NATURE OF SELF-OSCILLATIONS OF THE WHEELSET
Authors: Verbytskyi V. H. , Demchenko V. O.
Published: June 2023

The conditions of dangerous-safe loss of stability defined only by geometry of wheel profile. At certain geometry of wheel self-oscillations exist at supercritical speeds more; the stable limit cycle in this case limits growth of perturbations that corresponds to safe loss of stability. At infringement of some relationship of parameters of the wheel profile the unstable limiting cycle limits area of stability of rectilinear motion already at speeds less critical, narrowing an interval of operational speed; at speeds more critical growth of perturbations will be unlimited - a case of dangerous loss of stability.
REDUCING THE ANGLE OF ATTACK OF A THREE-AXLE BOGIE LOCOMOTIVES
Authors: Yevstratov O. S. , Kossov V. S.
Published: June 2023

The mechanism of radial wheelset positioning due to the central acceleration provides efficient reduction of the angle of attack and of a lateral displacement. The results obtained theoretically are confirmed by tests.
THE STUDY OF STRUCTURAL CHANGES NEAR THE TREAD AREA OF RAILWAY WHEELS DURING OPERATION
Authors: Yesaulov V. P. , Proidak Yu. S. , Hubenko S. I. , Sladkovskyi O. V. , Iskov M. , Ruban V. M.
Published: June 2023

The structural and chemical changes near the tread surface of the railway wheels with the different tread profiles during operation were investigated. The influence of the structural changes in steel on forming of the micro-destructions and tread wearing was determined. The advantages of the complexcurvilinear tread surface were shown.
DEVELOPMENT OF A MATHEMATICAL MODEL OF THE DRIVE WITH LINEAR SYNCHRONOUS MOTOR FOR RESEARCH OF TRANSIENTS
Authors: Zaitsev O. M. , Voskoboinyk V. E. , Komarov S. V. , Voroshylov O. S.
Published: June 2023

The variant of mathematical model of the linear synchronous electric drive which allows to take into account features of a design and a ratio of parameters is offered. The model allows to investigate electromechanical and thermal processes in the linear electric drive with synchronous motor.
THE PROBLEM OF "WHEEL-RAIL". THE QUALITY OF INTERACTION
Authors: Ivanov P. S. , Lesun O. F. , Bukin M. M. , Petrov O. O. , Churashov O. O. , Zaitsev M. I. , Rodionov O. V.
Published: June 2023

Discrepancy of parameters of the track and rolling stock interaction with standards of Russian and CIS countries railways leads to the sharp increase of rails defects, rails and wheels wear the maximum of which falls on 1995. An elimination of supernormal railway track narrowing has positive effect on the reduction of wheels and rails defects.
THE REDUCTION OF FRICTIONAL RESISTANCE IN THE CURVES
Authors: Kossov V. S. , Panin Yu. O.
Published: June 2023

The concept of combined rail lubrication, the results of theoretical and experimental researches of its efficiency are considered.
THE CHOICE OF PARAMETERS OF THREE-PIECE TRUCK OF A FREIGHT CAR BY MEANS OF COMPUTER SIMULATION OF ITS DYNAMICS
Authors: Kossov V. S. , Sorochkin E. M. , Mikhalchenko H. S. , Pohorielov D. Yu. , Simonov V. O.
Published: June 2023

Some results of designing a three-piece bogie of a freight coach with the help of a precise computer model are presented. The computer model is developed using the Universal Mechanism software. The Hierarchy Analysis Process is applied to choose the rational solution in the parameter space of the model.
SIMULATION MODEL OF TRAIN MOVEMENT IN SMALL-RADIUS CURVES
Authors: Krec S. , Janjanin S. , Stipetic A.
Published: June 2023

on the curved sections of track movement of trains as defined in the transverse vibrations of the system "train - path." The simulation model of the system is made in MATLAB language. In tight curves when driving at maximum permitted speed system works under extreme conditions, causing high stress in a carriage and in the train path. Moreover, the system operates with the limit from the viewpoint of safety. The need to quantify the wear of the railway track and trains, assess safety and comfort is particularly relevant at the present time in connection with the commissioning of tilting train, for which the transverse vibrations of the train is very significant. The simulation model also includes the ability to prepare for the measurements and experimental studies, because it allows you to get accurate results, which are expected during sea trials in normal and extreme conditions, leading to time and cost savings.
FORMATION OF ECONOMIC CONCEPTION ABOUT GLOBALIZATION: TO PROBLEM OF STATEMENT
Authors: Aitov S. Sh.
Published: June 2023

The article analyses the issue of peculiarities and stages of development of economic theories about globalization processes.
FORMATION OF EFFECTIVE SYSTEM OF MANAGEMENT OF CORPORATE RIGHTS OF THE STATE
Authors: Radionova N. V.
Published: June 2023

The article considers the issues and main directions of formation of an effective control system over the state corporate rights in present-day market economy conditions inUkraine.
FUNCTIONAL BLOCKS IN CONTROL SYSTEMS OF ROLLING STOCK
Authors: Viktorov V. H.
Published: June 2023

The article proposes to arrange the equipment of control systems as separate functional blocks, each of which operates only one object. Proceeding from requirements to the control system as a whole and necessity of meeting the dependences, determined by the logic of its work, the authors have suggested an algorithm of development of functional blocks. The final automatic device is accepted as a mathematical model of the functional block. For the analysis of its works within the rolling stock operation systems, it is expedient to use the tables of transitions.
MEASUREMENT OF RESIDUAL THERMAL STRESSES IN TRUSS PLATE OF LOCOMOTIVES TRUCKS VL60
Authors: Leonets V. A. , Tokariev O. D. , Trehub A. I. , Chaus L. M.
Published: June 2023

Assessment of the value of thermal residual stresses in stiffness ribs produced in accordance with the second constructive and set on in bogie frames of ВЛ60 electric locomotives. Resonant frequency of their lateral oscillation is calculated. A conclusion is made concerning the possibility of their fracture due to the impact loading acting on a bogie frame.
ABOUT MEASURING VERTICAL FORCES IN FREIGHT CAR BOGIES
Authors: Manashkin L. O. , Miamlin S. V. , Pysmennyi Ye. O.
Published: June 2023

A method of compensation of longitudinal forces influence on the results of measurements of vertical forces in an axle-box and a side-frame interaction of the freight car three-piece bogie is presented in the paper.
NUMERICAL SIMULATION OF LONGITUDINAL AND DYNAMIC PROCESSES IN FREIGHT TRAINS WITH DISTRIBUTED TRACTION
Authors: Muhinshtein L. O. , Yabko I. O. , Lisieiev S. I.
Published: June 2023

A mathematical model is developed to estimate longitudinal forces in freight cars in various control regimes. The corresponding software is created. Now more than 30 railway sheds use it.
CALCULATED AND EXPERIMENTAL METHOD OF DETERMINATION OF FLUX LINKAGE
Authors: Novikov V. F. , Burylov S. V. , Voskoboinik V. E. , Dzenzerskyi V. O.
Published: June 2023

A method for the indirect measuring of coil interlinkage with the pack of permanent magnets is offered. The method is independed on coil dimensions and based on magnetic field induction measurement of permanent magnets pack with the following integration of the induction with changeable limits.
STATISTICAL SEMI-MARKOV MODEL FOR RELIABILITY EVALUATIONOF ELECTROMECHANICAL SYSTEMS
Authors: Kazhan V. Ye.
Published: June 2023

The paper considers the «Polumarkovskaya» model of operation process and suggests an algorithm of electromechanical system reliability performances, based on the methods of statistic modeling.
TRUCK FOR HIGH-SPEED PASSENGER WAGONS OF UKRAINIAN RAILWAYS
Authors: Prykhodko V. I. , Korobka B. O. , Radzykhovskyi O. O. , Shkabrov O. O.
Published: June 2023

The description of bogie for high-speed passenger cars of Ukrainian railways is adduced
SYMMETRIC DIFFERENCE OF SETS AND ITS APPLICATION
Authors: Bosov A. A.
Published: June 2023

The article proposes fundamentals of a differential calculus of multitude functions.
STRUCTURAL MODELING, WHEN THE NUMBER OF EXPERIMENTS IS LESS THAN THE NUMBER OF INDICATORS
Authors: Kodola H. M.
Published: June 2023

On the basis of the method of ε -orthogonalization, a technique of constructing mathematical models with a minimum error has been proposed under the test data, when the number of indices exceeds the number of tests.
COMPREHENSIVE MODERNIZATION OF BOGIES 18-100 TO REDUCE WHEEL WEAR AND IMPROVE RIDE QUALITY OF FREIGHT CARS
Authors: Gregg Hansen W. M. , Lashko O. D. , Ushkalov V. F. , Mokryi T. F. , Malysheva I. Yu. , Mashchienko I. A.
Published: June 2023

Based on theoretical and experimental studies, combined retrofit of standard (18-100) freight-car trucks is proposed. This retrofit makes it possible to increase the maximum running speed by 30 to 40 km/h, to extend the service life of damping system elements of bolster suspension by a factor of 5 to 10, to reduce substantially the center plate arrangement wear intensity, to decrease the wheel flange wear nearly by a factor of 2, to reduce traction power consumption by decreasing the wheel/rail interaction.
THE PROCESS OF STUDY IN THE FIELD OF TRAMS’ MODERNIZATION
Authors: Chudzikiewicz A. , Bogacz R.
Published: June 2023

The main purpose of the article is to show the accepted assumptions and the investigation process necessary to modernize the tram of type 805Na. The modernization process is one of the elements of the tram renovation strategy in Poland [1]. One to the complexity of the task the investigation started after the tram to be modernized had been chosen and finished when the modernized tram went into operation. The above mentioned modernization concerns the complete modernization and means the creation of a modern design tram of type 805Na, that meets the current requirements of both the transportation service and passengers.
ANALYSIS OF THE CONDITIONS AFFECTING ON THE SAFETY OF FREIGHT CARS WITH COMPUTER SIMULATION METHODS
Authors: Cherkashyn Yu. M. , Lievinzon M. O. , Mikhalsenko H. S. , Pohorielov D. Yu. , Simonov V. O.
Published: June 2023

Results of computer modeling of some situations influencing the safety factors of a freight railway vehicle with respect to the derailment are considered. Modeling is performed by means of the Universal Mechanism software with the use of sufficiently detailed models of the freight coach (hopper).
MATHEMATICAL MODELING OF SHOCK ABSORBERS
Authors: Myamlin S. V. , Pysmennyi Ye. O. , Yalovyi O. I. , Manashkin L. A.
Published: June 2023

The article proposes mathematical description of interaction of two solid bodies, connected by an elastic tie. The proposed mathematical model of shock absorbers can be used in more complex mathematical models of spatial oscillations of railway vehicles.
THE CHOICE OF THE MINIMUM RADIUS OF CURVES IN THE DESIGN OF HIGH-SPEED RAILWAYS
Authors: Kirpa H. M.
Published: June 2023

In article foreign norms of designing of high-speed railways and influence of the minimal radius of a curve on cost indexes of a line are examined. Recommendations on application of those or other norms are given.
DYNAMICS OF BODY ROLLING IN THE CASE OF STEADY MOTION
Authors: Bosov A. A. , Ilman V. M.
Published: June 2023

This article offers you the analysis of dynamics of moving rolling element along horizontal deforming base. For rolling, like O. Reinolds, was found the conditions of steady rolling of element and was demonstrated, that the rolling without towing and slipping are possible.
A MODIFIED REGRESSION ANALYSIS IN STRUCTURAL MODELING
Authors: Bosov A. A. , Mukhina N. A.
Published: June 2023

The problem of structural modelling with the help of specially organized regression analysis has been considered.
ENSURING THE DURABILITY OF CONCRETE IN AGGRESSIVE ENVIRONMENT
Authors: Klochko B. H. , Bychkov S. O. , Momot V. O. , Kushvid A. A. , Hrynko D. V. , Punahin V. V.
Published: June 2023

The article presents the results of experimental and theoretical studies, aimed at improvement of antisulphate stability of concrete in the structures, operated in conditions of a sulphate aggression. It has been shown that usage of a mathematical model of concrete anti-corrosion stability enables to calculate the ratio of anti-sulphate stability and to forecast the service time of the structures, made from reinforced concrete.
THE USE OF COMPOSITE MATERIALS IN HYDRAULIC ENGINEERING
Authors: Klochko B. H. , Bychkov S. O. , Momot V. V. , Horidko D. V. , Punahin V. V.
Published: June 2023

The paper provides main definitions and technological principles of obtaining the composite materials, used in hydro-technical construction. Experimental data have been presented for steel-fiber-concretes, destined for preparation of monolithic coatings with the set properties.
POSSIBLE METHOD TO DETERMINE THE VOLUME OF EARLY WORKS IN THE ORGANIZATION OF TECHNICAL COVER OF THE RAILWAY DIRECTIONS
Authors: Pochtar V. P.
Published: June 2023

The paper deals with one of the practical ways of determining the necessary volumes of preliminary works at the railway objects in the course of planning and organization of their technical cover. This issue has not been examined by Ukrainian authors before.
THE OPERATION OF PASSENGER TRAINS WITH THE RANDOM VOLTAGE IN THE TRACTION NETWORK AND VARIABLE TARIFFS FOR ELECTRICITY
Authors: Yevdomakha H. V. , Ivchenko Yu. M. , Skalozub V. V. , Zhelieznov K. H. , Litvinov V. A. , Ivanov O. P.
Published: June 2023

The authors propose models and calculation methods for optimal modes of running emu trains, taking into account the random character of catenary voltages and the conditions of dependence of electric power price upon the time of day. The paper suggests criteria for efficient use of variable tariffs and provides examples of calculating the optimal modes of running suburban emu trains.
THE CALCULATION OF THE OPTIMAL SIZE OF THE SUPPORT DEVICES IN QUEUEING SYSTEMS, NOT ORDINARY BY TIME
Authors: Poslaiko N. I.
Published: June 2023

The paper concerns a queuing-type mass service system, being disturbed by a non-stationary, non-ordinary Poisson flow of requests, when the intensity of serving is a function on time. On the basis of numerical methods, a technique of calculating the optimal number of serving devices has been offered.
ANALYSIS OF THE IMPACT OF NEW DESIGNS ON THE STRESS-STRAIN STATE OF THE PROCESSING THE PYLON STATION
Authors: Siedin V. L. , Petrenko V. D. , Tiutkin O. L.
Published: June 2023

The article features a numerical analysis of influence of new design decisions in constructions of pylon stations. It has been concluded that introduction of any new elements in the construction of an underground structure requires a detailed analysis, because the tensed-and-deformed state of the structure in such cases does not always change for the better.
THE STUDY OF THE DYNAMICS OF IRREGULAR SPAN LENGTHS OF BRIDGE STRUCTURES
Authors: Soldatov K. I. , Zhelezniak H. S. , Hurzhii K. V.
Published: June 2023

The article is devoted to the possibility of replacement of complex inseparable irregular bridge structures by their regular counterparts, with minimal errors in definition of the own frequencies. The analysis has been performed on a real five-span bridge structure, designed under a 66 +126 +147 +115 + 76 – meter scheme.
THE USE OF "FILTERS" FOR IN-DEPTH ANALYSIS OF THE BEHAVIOR OF THE SYSTEM "LINING-ARRAY" IN THE CALCULATIONS OF UNDERGROUND STRUCTURES
Authors: Petrenko V. I. , Petrenko V. D. , Tiutkin O. L.
Published: June 2023

The modernization of account process by a finite elements method with the help of reception of «filtering» is resulted in submitted article. The algorithm and the kinds of «filters» are given which allow receiving more extensive and precisely built information on the results basis of professional settlement complexes account is stated.
STUDIES OF POLYMER SOLUTIONS BASED ON UREA RESINS FOR THE RECOVERY OF CONCRET ELEMENTS OF TRANSPORT OF HYDRAULIC STRUCTURE
Authors: Pshinko O. M. , Krasniuk A. V. , Kharchenko Ye. S.
Published: June 2023

The article presents the results of research on determination of rheological and strength characteristics of polymer mortars, based on carbamide resins. The models have been obtained, reflecting rheological and strengths properties of the material. The optimal compositions have been determined for performance of reconstruction works of concrete-based hydro-technical transport structures.
THE DYNAMIC CHARACTERISTICS OF NONLINEAR VIBRATION OF ABSORBER DESIGNS
Authors: Volkova V. Ye.
Published: June 2023

The object of the present study is one-mass vibro-percussion dampers. Hybrid modelling was chosen as the main testing method. The time processes, spectral characteristics and phase trajectories for dynamic dampers with the piecewise-and-linear elastic characteristic, having limiters with an initial backlash, with different segments of elastic ties rigidity or with initial tightness have been described.
THE STIFFNESS OF THE PILLARS OF REAL BRIDGE STRUCTURES
Authors: Soldatov K. I. , Zhelezniak H. S. , Hurzhii K. V.
Published: June 2023

The article considers the questions of defining the actual rigidity of bridge supports and arising in some cases necessity of replacement the absolutely rigid supports for resilient ones in calculation of the own frequencies of bridge designs.
ABOUT THE LIFE OF SMALL AND MEDIUM BRIDGES ON THE PERIPHERAL ROADS
Authors: Soldatov K. I. , Madatov V. I.
Published: June 2023

Based on the results of examination of a large number of bridges, the article proposes a completely new approach to designing, construction, maintenance and service terms of periphery bridges.
THE TIME TRAINS LOSSES ON SECTIONS OF SPEED LIMITS
Authors: Kurgan M. B. , Markova O. S.
Published: June 2023

The analytical dependence of the time loss from the speed which limits train movement has been defined.
ASSESSMENT AND FORECASTING OF THE FINANCIAL CONDITION OF THE COMPANY BY THE METHOD OF DISCRIMINANT FUNCTIONS
Authors: Savchuk L. M. , Vozianova V. I. , Kovalchuk H. K.
Published: June 2023

The original model of estimation of the financial state of enterprise on two integral financial criteria is grounded in work – indexes of profitability and liquidity of assets. It is taken this approach for prognostication of the financial state of enterprise and development of recommendations for stabilization of the folded situation.
THE STUDY OF THE DEFORMATION PROCESS OF BOX-TYPE STRUCTURES UNDER THE ACTION OF COMPRESSIVE LOADS
Authors: Bohomaz H. I. , Hudramovych V. S. , Sobolevska M. B. , Syrota S. O. , Khrushch I. K. , Horobets D. V.
Published: June 2023

The results of experimental researches of deformation character of construction as truncated pyramid with additional stiffening plate at compressing loadings are given. Stiffening plate influence on organization of the purposeful construction crush process with the purpose of their energy absorption properties increase is determined.
SOME PROBLEMS SOLUTION OF THE THEORY OF VIBRATIONS WITH REGARD TO THE ROLLING FRICTION
Authors: Bondarenko L. M. , Kolbun V. V.
Published: June 2023

The row of tasks of theory of vibrations is decided with the use of dependences for analytical determination of coefficient of friction of cachenie.
THE DESIGN AND TECHNOLOGY IMPROVING OF THE FREIGHT CARS REPAIR
Authors: Myamlin S. V. , Panasenko V. Ya. , Klymenko I. V.
Published: June 2023

In this paper some solutions to improve cargo cars construction were proposed these solutions help also to improve the conditions of work at railway field and safety of trains movements.
THE PARTIAL SOLUTION FOR THE OPTIMIZATION OF THE GEOMETRICAL SHAPE OF BUNKERS AND SILOS
Authors: Bannikov D. O.
Published: June 2023

In the paper analytical solutions for optimization of external geometrical shape according to criteria of massminimum of bunker and silo capacities for granular materials are presented. The special case of two-parted construction with the vertical upper part was considered. The method of transformation to the problem with one unknown symbol was used. The given solutions are compared with solutions, which were obtained by the author according to the Lagrange method of uncertain multiplies.
THE IMPROVING CALCULATION OF FLEXURAL-TORSIONAL VIBRATIONS OF CONTINUOUS BEAMS AND FRAMES
Authors: Raspopov O. S.
Published: June 2023

The suitability logic models and associable matrixes to calculation flexural-torsion oscillations of continuous beam with distribution parameters are researched. The inferential matrixes to consider various combination of elastic constraints and given localized masses.
MODAL ANALYSIS OF POLE DESIGN OF THE STATIONS WITH REGARD TO ADDED MASSES OF SOIL
Authors: Tiutkin O. L.
Published: June 2023

In the article the results of modal analysis of metropolises station construction of pylon type of deep contour interval are represented. Comparison of results of calculation of station model without a surrounding array and taking into account added the masses of ground are conducted.