bluuebunny/crossref_metadata_2025 huggingface dataset:
Adherence to European Society of Cardiology Heart Failure Treatment Guideline in Haji Adam Malik General Hospital Medan
Authors: Wirtanto Ardy Putra , Sitepu Andika
Published: December 2021

Background. Heart failure is a public health problem and the main cause of morbidity and mortality in the world. The goal of the therapy is to reduce symptoms, prevents rehospitalization and increases survivability. Objective. To evaluate the adherence to the European Society of Cardiology for heart failure treatment at H. Adam Malik Medan hospital. Methods. The study was descriptive observational cross sectional design with medical record data of heart failure at H. Adam Malik Hospital, using consecutive sampling method. The adherence of guidelines was assessed by: (1) drug prescribing (“yes” or “no”), and (2) guideline adherence indicator (GAI), both GAI-3 or GAI-5, by calculating the proportion as the number of drugs prescribed by number of drugs indicated to the ESC guidelines. Results. From research, the predominant GAI-3 and GAI-5 were High, which were 54.9% and 59.5%, respectively. The recommended drug used based on indications were ACE-i / ARB (89.1%), beta-blockers (83.4%), MRA (73.6%), diuretics (93.7%), and digitalis (20,8%). Conclusion. The predominant category in adherence to the ESC heart failure treatment guidelines based on GAI-3 and GAI-5 is High.
Molecular Review: Effects of Physical Exercise in Skeletal Muscle Glucose Uptake
Authors: Rahmi Rahmi
Published: December 2021

Muscle contraction requires glucose as its main fuel. Glucose enters the muscle cells through diffusion facilitated by GLUT4. GLUT4 must be translocated from intracellular to the plasma membrane and T tubules during muscle contraction. This literature review will discuss how physical exercise can signal GLUT4 translocation for glucose uptake. Molecular signals induced by physical exercise are very complex and involve various molecules, one of which is AMPK and intracellular Ca concentration.
Dermatophyte Profile in Patients with Dermatophytosis in Polyclinic Dermatology and Venerology of the General Hospital Dr. Ferdinand Lumbantobing Sibolga in 2019
Authors: May Iyasya Sarumpaet  , Dian Dwi Wahyuni
Published: December 2021

Dermatophytosis is a superficial skin infection caused by dermatophytes that infected keratinous skin tissue, dermatophytes form molecules that bind to keratin as a source of nutrients in the formation of colonization. Dermatophytes that cause dermatophytosis are Tricophyton sp, Epidermophyton sp and Microsporum sp. To find out the Profile of dermatophytes in patients with dermatophytosis in the Polyclinic of Dermatology and Venerology Dr. Ferdinand Lumbantobing Sibolga in 2019 conducted observational research with cross sectional design. The sample of this study were 75 patients who were new patients and had not used antifungal drugs. This sample is then examined by examination of KOH and cultured and then identified by Scotch-tape Preparation in a microscope. The prevalence of dermatophytosis in this study was 23% of skin cases. The majority of dermatophytosis patients are women (52%), the most age group is 46-65 years (30.7%) and is most often found in housewives (24%). The dermatophytes species found were Trichophyton rubrum, Trichophyton mentagrophytes and Microsporum canis with the most species Trichophyton rubrum (37.3%), which was then followed by Trichophyton mentagrophytes (16%). Tinea corporis, tinea cruris, tinea capitis, tinea pedis and tinea unguinum are dermatophytosis cases that were found in this study. It can be concluded that Trichophyton rubrum is the most common cause of dermatophytosis in Dr. Ferdinand Lumbantobing Sibolga with Tinea corporis is the most classified classification of dermatophytosis.
Proposta de implementação de estratégias de monitoramento e controle para redução de perdas dos insumos nas instalações de serviços: estudo de caso na empresa Infortread
Authors: Gonçalves Mayara Moraes , Brito William de Souza , Souza Thalisson Figueiredo , Dutra Paulo José Franco , Oliveira Daniel Barroso de , Almeida Victor da Silva , Roberto José Carlos Alves
Published: December 2021

O presente artigo tem a finalidade de estudar alternativas operacionais para a empresa INFORTREAD, localizada em Manaus. Observou-se no diagnóstico organizacional que a empresa é reconhecida pela qualidade dos serviços prestados na região, porém, detectou-se que a organização necessitava rever seus processos, visando manter a qualidade e controlar os custos dos serviços realizados. Sendo assim, o presente estudo de caso tem como pergunta-problema: Como reduzir as perdas dos insumos nas instalações por meio da implementação e controle dos serviços? Como objetivo geral do estudo, apresenta-se uma proposta com estratégias voltadas à redução de perdas dos insumos nas instalações em relação aos serviços prestados, pois observou-se, na empresa, a falta de controle dos insumos utilizados. Os aspectos metodológicos deste artigo se caracterizam como pesquisa aplicada; exploratória, explicativa e intervencionista; sendo realizada uma pesquisa de campo. Busca-se, portanto, estruturar um mapeamento completo do processo, criar mapas inteligentes para a gerência e supervisionar as operações diárias, com ênfase na implantação do ciclo PDCA para melhoria contínua e da Curva ABC para reduzir a aquisição de insumos desnecessários. Pretende-se, também, elaborar um treinamento de redução de custos voltado para os técnicos de instalações e, assim, criar um formulário de controle para obter as informações dos insumos utilizados nas realizações dos serviços. Os resultados observados foram satisfatórios, a ferramenta da qualidade 5W2H foi utilizada como instrumento de organização da proposta inerentes às implementações necessárias à melhoria no setor indicado. Com isso, entende-se que os propósitos do artigo foram atendidos no sentido de que as ações propostas prepararam a empresa para solucionar os problemas relativos ao controle de custos e acompanhamento das ações, com o intuito de que houvesse melhorias na área de logística, sobretudo no controle de insumos e redução de perdas, evitando custos maiores para a organização, bem como os colaboradores tornaram-se mais conscientes quanto às responsabilidades de execução, obtendo-se uma melhoria na otimização do desempenho com o mapeamento dos processos e controle de estoque e seus materiais, isto sem perder a qualidade reconhecida no mercado por seus serviços prestados.
Comparative assessment of the qualities of commercial and synthetic transformer oils
Authors:   Institute of Petrochemical Processes named after academician Yu.H. Mamedaliyev, Azerbaijan National Academy of Sciences, Hasanova R.Z. , Ibragimova M.J. ,   Institute of Petrochemical Processes named after academician Yu.H. Mamedaliyev, Azerbaijan National Academy of Sciences, Nagiyev V.A. ,   Institute of Petrochemical Processes named after academician Yu.H. Mamedaliyev, Azerbaijan National Academy of Sciences, Kafarova N.F. ,   Institute of Petrochemical Processes named after academician Yu.H. Mamedaliyev, Azerbaijan National Academy of Sciences
Published: December 2021

. Petroleum transformer oils previously produced in the USSR met the requirements of ГОСТ 982-80. Balakhany oil and Dossor low-paraffin oil of the Emben field were the raw materials for obtaining transformer oil. The composition of transformer oils is taken into account when choosing raw materials and their regeneration. Т-1500у – transformer oil of improved quality, is used in electrical equipment up to 500 kV and up to 750 kV. ГК oil is a hydrocracking transformer oil, used in voltages up to 1150 kV, contains ionol. Тсп is oil from West Siberian oils, used up to 220 kV. This oil is of relatively low quality, characterized by a high sulfur content, low oxidation stability, and high dielectric loss tg. In the Institute of Petrochemical Processes of ANAS, research has been carried out on the selective purification of transformer oil distillate from Balakhany oil using a new highly effective solvent – ionic liquid (IL) – a quaternary ammonium salt of formic acid and a number of amines – morpholine, aniline or di-, triethylamines. The optimal conditions for the selective purification of the distillate have been developed. Due to the shortage of high-quality transformer oils, as well as the high cost, in recent years, oils have been imported from Sweden and Austria. An ionic liquid as a solvent is highly selective and selective. The analysis of the extract from selective purification showed that it does not contain naphthene-paraffins, the content of aromatic hydrocarbons in the extract is 65%, and when purified with furfural it is 40.8%. The ionic liquid is environmentally friendly.
Nepoznato ostvarenje arhitekta Hinka Vichre u Rijeci
Authors: Škunca Srđan
Published: December 2021

Stambena prizemnica sa suterenom, izgrađena daleke 1955. na adresi Istarska ulica 29, višestruko je zanimljiva za graditeljsku i urbanističku povijest grada Rijeke. Riječ je, naime, o zgradi sagrađenoj prema projektu koji naručuje Brodogradilište „3. maj“ u cilju nastavka izgradnje radničkog naselja na Zametu. U spomenutom naselju, međutim, bit će izvedene samo dvije zgrade smanjenih dimenzija, dok će izvorni projekt biti ostvaren samo na navedenoj lokaciji na Kantridi. Nadalje, riječ je o dosad nepoznatom radu zagrebačkog arhitekta Hinka Vichre, jednog od samo devetnaest diplomanata Škole za arhitekturu, koju je u okviru zagrebačke Akademije likovnih umjetnosti od 1926. do 1943. vodio Drago Ibler pa već iz ove činjenice proizlazi opravdano zanimanje za Vichrin projekt i rad o kojemu se i inače zna vrlo malo. Konačno, zanimljiv je i projektni pristup, koji u izvedbi povezuje tradicionalni način građenja suterenskog dijela s tehnologijom montažne izvedbe prizemlja primjenom skeletnog sustava „Izolit“. Riječ je o preteči sustava montažne ili industrijalizirane gradnje koju će od 1955. godine nadalje razvijati poduzeće „Jugomont“, a koja će kulminirati razvojem i primjenom sustava JU-61, ne samo na području tadašnje SR Hrvatske već i SFR Jugoslavije. S obzirom na mali broj istovrsnih građevina izvedenih na opisani način, riječki primjer zaslužuje barem dokumentiranje i osvrt.
Pregled dimenzioniranja Peltonove turbine
Authors: Sušanj Čule Ivana , Vračević Doris , Ožanić Nevenka
Published: December 2021

Unutar ovoga rada biti će dan pregled dimenzioniranja Peltonove turbine. Kako se pri radu turbine javljaju vrlo složeni uvjeti tečenja i fizikalni procesi, optimizacija i samo dimenzioniranje ovakvog sustava je izazov. Primjerice, u radu turbine javljaju se četiri režima tečenja: (i) stacionarno tečenje u uzvodnim i dovodnim cijevima, (ii) slobodni pad mlaza vode nakon izlaska s mlaznice, (iii) tečenje sa slobodnom vodnom površinom na lopaticama Peltonove turbine te (iv) raspršeno dvofazno tečenje na kućištu Peltonove turbine. S obzirom da postoji cijeli niz različitih formula i preporuka za dimenzioniranje, cilj ovoga rada bio je objediniti i dati pregled istih na jednom mjestu. Istraživanje za potrebe ovoga rada proizašlo je iz prethodnog istraživanja za potrebe izrade diplomskoga rada.
TOWARDS MAQASID SHARIAH IN SUSTAINING THE ENVIRONMENT THROUGH IMPACTFUL STRATEGIES
Authors: Yaakub Sabariyah , Nik Abdullah Nik Ab Halim
Published: December 2021

Maqasid Shariah requires the preservation of life on earth and with the relevance of environmental sustainability in protecting the earth and all life within it, the objectives of this paper is to investigate the strategies taken by a port in order to be environmentally sustainable and discuss it according to the principles of Maqasid Shariah. Qualitative research design was employed where data was collected through semi-structured interview with the officers in charge of environment at the company. Findings indicate that strategies implemented by the port have been successful in reducing emission and improve air quality which is an important step both to being environmentally sustainable and adhering to the Maqasid Shariah principles.
COMPARATIVE ANALYSIS OF ZAKAT DISTRIBUTION PROGRAM IN RIAU PROVINCE IN INDONESIA AND SELANGOR STATE IN MALAYSIA IN REDUCING POVERTY: A DYNAMIC ANALYSIS MODEL
Authors: Sastraningsih Ellyan , Basri Yuswar Zainul , Mariyanti Tatik , Zulhelmy Zulhelmy
Published: December 2021

This study is a comparative study between Riau Province in Indonesia and Selangor State in Malaysia with the aim of assessing differences in the zakat distribution program in reducing poverty in both regions, using the Tawhidi String Relationship (TSR) theory with a circular causation approach and a dynamic analysis model. The results of the study found that there were differences in the management of zakat in the two regions, differences in the effect of reducing poverty, differences in the amount of zakat collected and differences in the distribution of zakat funds. Research recommendation is Riau Province should unite the management of zakat in one institution to concentrated zakat funds and the distribution of zakat has a stronger multiplier effect in reducing poverty.
ANALYSING THE DRIVERS AFFECTING THE INTENTION TO USE ONLINE ZAKAT PAYMENT AMONG MUSLIM IN SHAH ALAM, SELANGOR
Authors: Ahmad Noryati , Roslin Roszahira Idayu , Nazrin Nur Fatin Syahira
Published: December 2021

In today’s business world, the traditional ways of doing business are rapidly being replaced with online transactions. More and more companies realise that they need to digitalize their operation processes to keep abreast with the local and foreign competitors. This practice is no exception to zakat institutions in Malaysia when they must seize this technology evolution to ease the zakat payers in fulfilling the obligation as Muslim via online payment system. This study aims to identify the determinants affecting the intention to use online zakat payment among Muslim in Shah Alam, Selangor. A structured questionnaire is distributed to 300 Muslim respondents Muslim using a convenience sampling technique. The results of the estimated multiple regression show that perceived usefulness, perceived ease of use and security and privacy critical drivers of intention to use online zakat payment while no significant relationship was found between trust and amount of information to use online zakat payment. Thus, the empirical findings of this study provide a point of reference to zakat institutions to leverage the usefulness and ease of use of the online collection zakat system to increase zakat collections. Additionally, the institution must also beef up its security and privacy of users to alleviate the acceptance of online system usage.
Urbanising Delta: What Lessons Dhaka Offers to Face Challenges
Authors: Abdullah Md. Sadaf , Nowreen Sara , Uz Zzaman Rashed , Hasnat Sakib , Satu Susmita Majumder , Chowdhury Md. Enayet
Published: December 2021

Cities built on deltaic regions are always prone to environmental risks like aggravated flooding, wetland reduction, compromised water quality, continuing water scarcity, and tainted air and these have been remarkable as the challenges while urbanizing deltas. On top of that, rapid urbanization adds more to the deterioration of ecosystem functions. Drawing insights from Bangladesh's capital Dhaka lying in the Ganges, Brahmaputra, and Meghna basin, this study basically appraises the common concerns of deltaic megapolises through a systematic literature review. The current literature has been brought up by analysing the status, factors, and impacts of the challenges and management by authorities. In addition, it is further updated with some urban experts' views, secondary records on groundwater levels, and remote sensing imageries. This paper also concludes with recommended guidelines from the reviews for more practical deltaic urbanization, especially when there is no turning back for urban transferability to a new region of the delta. Particularly, success demands (1) specifying current situation in quantifiable terms (e.g., numeric values, percentages, scores, indices), (2) practical but adaptive multi-objective plans/policies with a set of assessable targets, and (3) timely robust evaluation for tracking data for specific, measurable, and meaningful outcomes.
Can Lactobacillus spp. Be a Factor Reducing the Risk of Miscarriage?
Authors: KIECKA ANETA , MACURA BARBARA , SZCZEPANIK MARIAN
Published: December 2021

Pregnancy loss is a common obstetric problem. Significant causes of miscarriage include genetic and epigenetic disorders of the embryo, immunological and endocrine factors, uterine malformations, improper embryo selection, and lifestyle. Perhaps a hitherto underappreciated cause of miscarriage may be an abnormal microbiota composition of the female reproductive system. Lactobacillus spp. is the most common bacteria within the reproductive tract. However, the protective role of Lactobacilli in the vagina has been well described in the literature, while it is still unknown what function Lactobacilli may have in the uterus. Moreover, new research shows that Lactobacillus spp. can have a role in miscarriage. However, both molecular and immunological mechanisms of host-Lactobacillus spp. interactions are not fully understood. Understanding these relationships will help address the importance and extent of the protective role of Lactobacillus spp. in miscarriage.
Characterization of Airport Movement Sequence
Authors: Károly Bianka , Sághi Balázs
Published: December 2021

Runways as the most critical parts in the aviation infrastructure have a great impact on the whole aviation effectiveness. Our present research has attempted to provide a better understanding of the nature of the sequence between the runway movements. For that traffic data of a typical medium-capacity airport was analyzed.
A comparative study of oral Ketoconazole versus Itraconazole in the treatment of Tinea versicolor
Authors: Begum Sharmin , Karim Md Nazmul , Haque AKM Rejaul , Rahman Rahat Mohammad Lutfur
Published: December 2021

Tinea (pityriasis) versicolor is a superficial fungal infection and one of the most commonly found pigmentary disorders of the skin caused by the yeast Malassezia. Multiple topical as well as systemic therapies are available for treatment. Systemic therapies are used for extensive disease, frequent relapse or where topical agents have failed. The aim that translates the rationale of the study was to compare the efficacy, safety, tolerability and cost effectiveness of oral ketoconazole dose 200mg daily for 7 days versus a single dose of 400 mg of itraconazole in the treatment of tinea versicolor. A total of 64 patients (aged 18-50 years) were selected for the study from the period of June 2019 to November 2019 in the Department of Dermatology and Venereology, Bangabandhu Sheikh Mujib Medical University, Bangladesh. Cases having extensive involvement were diagnosed clinically and confirmed by wood's lamp and KOH microscopy was taken. Patients were randomly allocated into equal groups. Group A was given oral ketoconazole dose 200mg daily for 7 days and Group B has given a single dose of 400 mg of itraconazole. 47 (73.4%) male and 17(26.6%) female were included in the study. The mean age of group A was 29.2(SD±8.6) and in group B 28.2(SD±8.5) years. The mean duration of the disease in group A was 3.9(±2.7) months and 3.5(±2.2) months in group B. In group A clinical responders was found cure 25(78.1%), improvement 5(15.6%) and failure in 2(6.2%) and in group B it was found cure 22(68.8%), improvement 7(21.87%) and failure 3(9.4%) at one month. At two months in the group A clinical responder was found to cure 22(68.8%), improvement 5(15.6%), failure in 3(9.4%) and relapse 2(6.2%). In group B it was found cure 18(56.2%), improvement 6(18.75%), failure 4(12.5%) and relapse 4(12.5%). Both oral ketoconazole dose 200mg daily for 7 days versus single dose 400 mg of itraconazole can be effective in the treatment of tinea versicolor with extensive involvement.

CBMJ 2020 July: Vol. 09 No. 02 P: 26-33
Internet-of-Things based Home Automation System using Smart Phone
Authors: Sharif Zubair
Published: December 2021

Smart homes can be of great benefit for both, energy and water management which not only helps to save money but can be highly beneficial for the environment. Such smart automation not only offers optimum consumption of these resources but also leads to higher comfort and conveniences for the users and residents. Recent developments in sensing, networking and communication technologies offering new and advanced forms to link a variety of things around us even with the people. Further, integration of internet of things (IoTs) services by embedding intelligence into these sensors and actuators and connecting them smartly are gaining great popularity to enhance the comfort and quality of life. This paper presents a flexible and low-cost home automation system using various sensors to control the commonly used home appliances and devices where IP connectivity is provided to access and manage them remotely. For this purpose, an Android-based app is developed which can be installed on any smartphone in order to monitor and control the devices from any location. The evaluation of the integrated sensors with the devices and switches shows that the system can offer great automation to achieve the idea of smart homes.
18-65 YAŞ ARASI KİŞİLERİN ANTROPOMETRİK VERİLERİNİN BELİRLENMESİ ÜZERİNE BİR ALAN ARAŞTIRMASI: YÜKSEKÖĞRETİM KURUMU UYGULAMASI
Authors: ÇALIŞ Serenay , ÇALIŞ Çağdaş , KOÇALİ Kaan , BÜYÜKAKINCI Banu Yeşim
Published: December 2021

Zaman ilerledikçe ve yeni nesiller ortaya çıktıkça insan hayatındaki pek çok ürün, araç-gereç, teknolojik makineler gibi ihtiyaçlar da çeşitlenmektedir. Bu durum sürekli yeniyi üretmeyi, ihtiyaca cevap vermeyi ve bunun yanında üretilenlerden de fiziksel olarak memnun kalmanın sağlanması çalışmalarını da gerektirmektedir. Bu değişimler göz önünde tutulduğunda ihtiyaç duyulan alanların başında Ergonomi olduğu açıktır. Ergonomi, çalışma ortamının, iş yerlerinin, kullanılan makine ve ekipmanların insanın fiziksel ve psikolojik sınırlarına uygun olarak üretilmesini antropometrik çalışmalarla gerçekleştirmektedir. Tamamlanan bu araştırma, en güncel haliyle Türkiye’deki durumu ortaya koymak, üniversitelerde antropometrik çalışmaların bilinmesinin sağlayabileceği faydaları ortaya çıkarmak ve bu verilerin nerelerde kullanılabileceği konusunda öneri getirmektedir. Çalışmada alınan ölçümler üniversite kampüsünde öğrencilere, idari ve akademik olmak üzere 18-65 yaş arası 1009 kişiye uygulanmıştır. Ölçüm noktalarının belirlenebilmesi için postür türüne (ayakta) göre fotoğraflar çekilmiş ve bu veriler elektronik ortama aktarılarak AutoCad programı ile ölçülmüştür. Her kişi için 16+2 (tanımlayıcı veri) adet veri belirlenmiştir. Antropometrik ölçümlerin çalışmanın amacına uygun şekilde yorumlanabilmesi için SPSS analiz programı kullanılmıştır. Elde edilen veriler incelendiğinde kadın ve erkeklerin vücut ölçülerinin birbirinden farklı olduğu, aynı cins grupların içerisinde yaşa göre bile farklılık olduğu saptanmıştır.
Metabolic rates mirror morphological and behavioral differences in two sand-dwelling coral reef gobies
Authors: Brandl SJ , Quigley CN , Casey JM , Mercière A , Schiettekatte NMD , Norin T , Parravicini V , Côté IM
Published: December 2021

Morphology, physiology, and behavior are the primary axes of organismal diversification, and phenotypic differentiation among species in any of these dimensions can be indicative of where, when, and why species can occur and coexist. However, nuanced adaptations in superficially similar species can be difficult to pinpoint, especially for mobile animals in highly diverse ecosystems, such as coral reef fishes. In this context, morphology and behavior are often investigated to assess potential differences, but interspecific variation in physiological traits is not frequently considered. Here, we use field surveys, morphometrics, behavioral observations, gut content DNA metabarcoding, and metabolic rate trials to investigate phenotypic differentiation in 2 small sympatric species of sand-dwelling cryptobenthic coral reef fish. We show that the gobies Fusigobius neophytus and Gnatholepis cauerensis co-occur in sandy habitats throughout a coral reef lagoon in French Polynesia. While superficially similar, the 2 species differ in the length of their gastrointestinal tracts, their ingested prey, and their foraging rates. These differences are also reflected in the species’ standard and maximum metabolic rates: G. cauerensis has a longer intestinal tract and ingests more animal prey, has a more active foraging style, and displays markedly higher standard and maximum metabolic rates than F. neophytus. These results indicate clear differences in the functional niches of the 2 species, which are detectable across these 3 major organismal axes. Given the well-documented direct links between metabolic rate and organismal energy expenditure, we suggest that physiological traits may offer a useful additional dimension in the assessment of sympatric species and their functional roles.
Correlation Between Nongenomic Action of C19-Steroids and COVID-19 Severity
Authors: PERUSQUÍA M
Published: December 2021

The recent COVID-19 pandemic is the defining global health crisis of our time and little is known about this disease. It has been reported that advanced age is considered a major risk factor for COVID-19 complications, and data suggest that this disease is deadlier for men than women but these observations are currently unclear. Regarding androgen action, it has been shown that certain smooth muscles are a target for androgens by inducing an acute relaxing effect in airway and vascular tissues that is nongenomically mediated; likewise, androgens are capable of inducing genomic anti-inflammatory and nongenomic hypotensive responses. The aim of this report is to associate the relationship between COVID-19 and aging men as well as the comorbidities presented in this group of patients linked with androgen deficiency. Remarkably, the nongenomic mechanisms of androgens as potential protectors are reviewed. On this basis, it is suggested that hypotestosteronemia may be a risk factor for COVID-19 severity.
Comparative Assessment of the Dynamics of Immunological Reactivity in Patients With Postoperative Ventral Hernia
Authors: Kurmanov R. , Osmonbekova N. , Aitiev U. , Ashimov Zh. , Dinlosan O. , Ibraimov B. , Rysbek uulu Z.
Published: December 2021

Postoperative Ventral Hernias to this day remain one of the main pathologies of planned and urgent surgical interventions. The purpose of the study is to study the immune response in patients with postoperative ventral hernias who underwent auto and alloplastic hernioplasty methods. The study included 40 patients diagnosed with postoperative ventral hernia, including 25 men (62.25%) and 15 women (37.5%). In men, the average age was 45.6±2.3 years, and in women 57.2±3.2 years. Patients are divided into 2 groups. Group I are patients who underwent autoplastic methods and group II patients who underwent alloplastic hernioplasty methods. The complex of immunological examination included the determination of a subpopulation of lymphocytes with CD3, CD4, CD8, CD20 receptors, interleukin 6, interleukin 10 and immunoglobulins A, M, G. Immunological examination of blood parameters in patients with postoperative ventral hernias revealed the following changes. There is an upward trend in all indicators. In group I, the leukocyte level was increased by +0.2±0.01, and in group II, the indicators were within the normal range. The level of monocytes in patients who underwent alloplasty increased by +1.5±0.2. There was an increase in the concentration of T and B lymphocytes with GD3, CD4, CD8, CD20 receptors on the 7th day after surgery in patients of the first group was +1.85±0.3, +1.6±0.4, +1.6±0.1, +1.5±0.2. And in patients of the second group, the initial level of indicators was lower and increased by +1.2±0.1, +1.4±0.2, +1.67±0.65, +1.03±0.45. The level of IL6 and IL 10 in the postoperative period increased in patients of the first group by +1.55±0.2 and +1±0.9, in the second group it was IL 6 +0.9±1.2, IL 10 +0.8±1.2. The study shows that the indicators of the humoral cell type tended to increase, which shows the result. Conclusions. Patients with postoperative ventral hernias who have undergone autoplastic and alloplastic hernioplasty methods in dynamics, the immunological reactivity indicators significantly increase on the 7th day, in comparison with the initial blood parameters. Namely, in patients who have undergone autoplastic methods of hernioplasty. The use of conventional suture materials in autogernioplasty increases the risk of developing an inflammatory process in the early and long-term postoperative period, in contrast to the use of polypropylene mesh prostheses.
Automation of Agricultural Business-Processes
Authors: Erlygina E. , Shuvalova V.
Published: December 2021

The article discusses the possibilities of implementing and using a Customer Relationship Management (CRM) for agriculture. The introduction of CRM systems at the enterprises of the agro-industrial complex makes the automation of processes more rational. Communications with clients become more effective, the effectiveness of marketing strategy and planning increases, costs decrease, and the profitability of the company increases. CRM is a key factor of modern organizations for a set of successful strategies for survival, growth and development, increasing productivity efficiency and sustainable competitive advantage. Relationships and knowledge are the most important strategic resource, the main element of a sustainable competitive advantage.
Developing an Innovative Economic System for Support for Entrepreneurship
Authors: Nazarova F. , Khamdamova G. , Kostyuchenko A. , Nazarova U.
Published: December 2021

This article reflects existing trends in the development of an innovative economic system to support entrepreneurship in the modern economy. The detailed analysis of the business development component will allow us to consider the situation in Uzbekistan related to the development of conditions for innovative entrepreneurship. In addition, the work contains the planned main legislative initiatives of the Ministry of Innovative Development, which conducts an active policy on the formation of an institutional environment aimed at the systematic creation of the necessary conditions for the functioning of innovative entrepreneurship.
Tendencies and Priority Directions Industry Development in the Region
Authors: Kalmuratov B.
Published: December 2021

The article describes the main directions of development the industry in context of globalization. Identified problems of development the industrial sector on territory of Republic Karakalpakstan.
Development and Formation History of Profit Taxation
Authors: Kaparova G. , Mazhitova D. , Abdullaeva Zh.
Published: December 2021

Research relevance determined by the importance of tax regulation, which allows the state to concentrate its financial resources, with the ability to significantly influence the economic development of the country at every stage of its development. The article examines the processes and stages of the emergence and evolution of theses on the essence of taxation. Research objectives: analysis of the main and fundamental tax theories, as well as tax systems of ancient states. Research materials and methods: analysis of the history of formation, development, evolution of one of the initial forms of taxation — payment (tax) from the people. Also considered the legal content and the economic content of the tax. Research results: the basic principles of taxation are considered on the basis of the definitions of Adam Smith, who established the basic principles of taxation, which exist and operate to this day. An assessment and comparison of taxation in Kyrgyzstan with other countries is given. Conclusions: a decrease in the tax rate will entail an increase in production, which in the future will compensate for a temporary decrease in tax revenues.
Psychological Correction of School Deadaptation of Pupils at the Transition to the Middle Level
Authors: Antonova D. , Ivanov D.
Published: December 2021

The article is devoted to the study of the effectiveness of methods of psychological correction of school deadaptation of fifth graders during the transition from junior to middle level. The problem of school deadaptation in the Russian pedagogical and psychological literature is revealed. The features of deadaptation in primary school age during the transition to the secondary level of education, the features of the correction of school deadaptation of pupils are revealed. Particular attention is paid to the study of manifestations in individual components of school deadaptation: cognitive, emotional-evaluative, behavioral, and personal. A package of psychological diagnostic techniques has been developed. The description of the study of maladjustment of primary schoolchildren during the transition to the secondary level of education is given. The content of the program of psychological correction of school deadaptation during the transition from junior to secondary level, including recommendations for teachers and parents, is disclosed. The results of diagnostics are presented. Analysis of the effectiveness of the program showed that the program allows achieving positive changes in the emotional-evaluative, behavioral and personal components of school deadaptation of fifth graders. At the same time, school adaptability increases.
PENGARUH FUNGSI-FUNGSI MANAJEMEN TERHADAP KINERJA APARATUR SIPIL NEGARA PADA KANTOR KECAMATAN MOLAWE KABUPATEN KONAWE UTARA
Authors: Sappodin Sappodin , Zaid Sudirman , Sinarwaty Sinarwaty , Rommy Nursaban , Hartini Hartini , Hasan Rachmad Rialdy
Published: December 2021

This study aimed to determine the Influence of planning, organizing, actuating and controlling  toward the performance of the State Civil Apparatus at the Molawe District Office, Konawe Utara Regency  simultaneously and partially. The sample in this study as many 35 people Apparatus State Civil who worked at the Molawe District Office, Konawe Utara Regency. Analysis tool  used is quantitative analysis using Multiple Linear Regression Analysis.The results showed that the simultaneous functions of planning, organizing, actuating and controlling had  significant effect on the performance of the State Civil Apparatus at the Molawe District Office, Konawe Utara Regency. And partial functions of planning, organizing and actuating had positif significant effect on the performance of the State Civil Apparatus at the Molawe District Office, Konawe Utara Regency, so that the hypothesis can be accepted.
PENGARUH GAYA KEPEMIMPINAN, MOTIVASI KERJA, DAN DISIPLIN KERJA TERHADAP KINERJA PEGAWAI PADA DINAS PENGENDALIAN PENDUDUK DAN KELUARGA BERENCANA KABUPATEN KONAWE SELATAN
Authors: Hasniati Wa Ode , Awasinombu Aidin Hudani , Hamid Wahyuniati
Published: December 2021

The purpose of this study was to examine and explain the influence of leadership style, work motivation and work discipline both partially and simultaneously on employee performance at the Population Control and Family Planning in South Konawe Regency. This research approach is quantitative using survey methods and explanatory research design. The data was collected by cross-section using an instrument in the form of a questionnaire. The population of this study were employees of the Population Control and Family Planning Office of South Konawe Regency, by using the method of determining respondents by census, so that the sample size was set at 84 employees. The analytical tool used is the Multivariate Regression Analysis.The results showed that the leadership style had a positive and significant effect on employee performance. Work motivation has a positive and significant effect on employee performance. Work discipline has a positive and significant effect on employee performance. Finally, leadership style, work motivation and work discipline simultaneously have a significant effect on employee performance. From the results of these studies it can be concluded that the better the leadership style is applied, the higher the work motivation of the employees and the better the level of work discipline applied by employees will be able to improve employee performance for the better.The purpose of this study was to examine and explain the influence of leadership style, work motivation and work discipline both partially and simultaneously on employee performance at the Population Control and Family Planning in South Konawe Regency. This research approach is quantitative using survey methods and explanatory research design. The data was collected by cross-section using an instrument in the form of a questionnaire. The population of this study were employees of the Population Control and Family Planning Office of South Konawe Regency, by using the method of determining respondents by census, so that the sample size was set at 84 employees. The analytical tool used is the Multivariate Regression Analysis.The results showed that the leadership style had a positive and significant effect on employee performance. Work motivation has a positive and significant effect on employee performance. Work discipline has a positive and significant effect on employee performance. Finally, leadership style, work motivation and work discipline simultaneously have a significant effect on employee performance. From the results of these studies it can be concluded that the better the leadership style is applied, the higher the work motivation of the employees and the better the level of work discipline applied by employees will be able to improve employee performance for the better.
PENGARUH SPIRITUAL LEADERSHIP, BUDAYA ORGANISASI DAN PERILAKU KERJA TERHADAP KINERJA PEGAWAI PADA RUMAH TAHANAN NEGARA KELAS IIB UNAAHA
Authors: Frediansyah Indra , Awasinombu Aidin Hudani , Samdin Samdin
Published: December 2021

The purpose of this study was to determine the effect; 1) the influence of spiritual leadership, organizational culture and work behavior simultaneously on employee performance. 2.) the influence of spiritual leadership, on employee performance. 3.) the influence of organizational culture on employee performance and 4) the influence of work behavior on employee performance. the research method is to use quantitative research. the data used are secondary and primary data. data analysis usingspss software version 20. the sampling technique uses saturated sample amounted to 51 employees at class iib unaaha state prison. the results showed that; 1) spiritual leadership, organizational culture and work behavior simultaneously have a positive and significant impact on employee performance. 2)spiritual leadershippositive and significant effect on employee performance. 3)organizational culture has a positive and significant effect on employee performance. 4) work behavior has a positive and significant effect on employee performance.
Multiplex-Heterogeneous Network-Based Capturing Potential SNP “Switches” of Pathways Associating With Diverse Disease Characteristics of Asthma
Authors: Ran Ming-Yu , Yuan Zhang , Fan Chui-Ting , Ke Zhou , Wang Xin-Xing , Sun Jia-Yuan , Su Dong-Ju
Published: December 2021

Asthma is a complex heterogeneous respiratory disorder. In recent years nubbly regions of the role of genetic variants and transcriptome including mRNAs, microRNAs, and long non-coding RNAs in the pathogenesis of asthma have been separately excavated and reported. However, how to systematically integrate and decode this scattered information remains unclear. Further exploration would improve understanding of the internal communication of asthma. To excavate new insights into the pathogenesis of asthma, we ascertained three asthma characteristics according to reviews, airway inflammation, airway hyperresponsiveness, and airway remodeling. We manually created a contemporary catalog of corresponding risk transcriptome, including mRNAs, miRNAs, and lncRNAs. MIMP is a multiplex-heterogeneous networks-based approach, measuring the relevance of disease characteristics to the pathway by examining the similarity between the determined vectors of risk transcriptome and pathways in the same low-dimensional vector space. It was developed to enable a more concentrated and in-depth exploration of potential pathways. We integrated experimentally validated competing endogenous RNA regulatory information and the SNPs with significant pathways into the ceRNA-mediated SNP switching pathway network (CSSPN) to analyze ceRNA regulation of pathways and the role of SNP in these dysfunctions. We discovered 11 crucial ceRNA regulations concerning asthma disease feature pathway and propose a potential mechanism of ceRNA regulatory SNP → gene → pathway → disease feature effecting asthma pathogenesis, especially for MALAT1 (rs765499057/rs764699354/rs189435941) → hsa-miR-155 → IL13 (rs201185816/rs1000978586/rs202101165) → Interleukin-4 and Interleukin-13 signaling → inflammation/airway remodeling and MALAT1 (rs765499057/rs764699354/rs189435941) → hsa-miR-155 → IL17RB (rs948046241) → Interleukin-17 signaling (airway remodeling)/Cytokine-cytokine receptor interaction (inflammation). This study showed a systematic and propagable workflow for capturing the potential SNP “switch” of asthma through text and database mining and provides further information on the pathogenesis of asthma.
Long Non-Coding RNA LINC01572 Promotes Hepatocellular Carcinoma Progression via Sponging miR-195-5p to Enhance PFKFB4-Mediated Glycolysis and PI3K/AKT Activation
Authors: Lai Shihui , Quan Zhipeng , Hao Yuesong , Liu Jun , Wang Zhiqian , Dai Luo , Dai Hongliang , He Songqing , Tang Bo
Published: December 2021

Background: Accumulating evidence indicates that type 2 diabetes mellitus (T2DM) is a risk factor for hepatocellular carcinoma (HCC), and T2DM-associated HCC represents a common type of HCC cases. We herein identify an lncRNA LINC01572 that was aberrantly upregulated in T2DM-related HCC via high-throughput screening. Based on this, the study was undertaken to identify the functional role and mechanism of LINC01572 in HCC progression.

Methods: RT-qPCR was used to detect the expressions of LINC01572 in HCC tissues and cell lines. Gain- or loss-of-function assays were applied to evaluate the in vitro and in vivo functional significance of LINC01572 in the HCC cell proliferation, migration, and invasion using corresponding experiments. Bioinformatics, RIP, RNA pull-down, and luciferase reporter assays were performed to explore the regulatory relationship of the LINC01572/miR-195-5p/PFKFB4 signaling axis.

Result: In this study, we profiled lncRNAs in HCC tissues and corresponding adjacent tissues from HCC patients with T2DM by RNA sequencing. Our data showed that LINC01572 was aberrantly upregulated in HCC tissues as compared with control, especially in those with concurrent T2DM. The high level of LINC01572 was correlated with advanced tumor stage, increased blood HbA1c level, and shortened survival time. The overexpression of LINC01572 significantly promoted HCC cell proliferation, migration, invasion, and epithelial-to-mesenchymal transition (EMT), while the knockdown of LINC01572 had the opposite effects on HCC cells. A mechanistic study revealed that LINC01572-regulated HCC progression via sponging miR-195-5p to increase the level of PFKFB4 and subsequent enhancement of glycolysis and activation of PI3K-AKT signaling.

Conclusion: LINC01572 acts as ceRNA of miR-195-5p to restrict its inhibition of PFKFB4, thereby enhancing glycolysis and activates PI3K/AKT signaling to trigger HCC malignancy.
Vitiligo: An Autoimmune Skin Disease and its Immunomodulatory Therapeutic Intervention
Authors: Chang Wei-Ling , Lee Woan-Ruoh , Kuo Yung-Che , Huang Yen-Hua
Published: December 2021

Vitiligo is a chronic autoimmune depigmenting skin disorder characterized by patches of the skin losing functional melanocytes. Multiple combinatorial factors are involved in disease development, among which immune T cells play a prominent role. The immune cells implicated in melanocyte destruction through adaptive immunity include CD8+ cytotoxic T cells and regulatory T cells, and aberrantly activated skin-resident memory T cells also play a role in melanocyte destruction. Over the past several years, major progress in understanding vitiligo pathogenesis has led to the development of targeted therapies. Janus kinase (JAK) inhibitors, which share the similar mechanism that autoactivates CD8+ T cells in chronic inflammatory diseases, have been reported to have therapeutic significance in vitiligo. Recently, immunomodulatory therapeutic interventions in vitiligo have been emerging. Mesenchymal stem cells (MSCs) regulate cytokine secretion and the balance of T-cell subsets, which makes them a promising cell-based treatment option for autoimmune diseases. The induction of MSC-mediated immunomodulation is complicated and occurs by contact-dependent mechanisms and soluble extracellular vesicle (EV) mediators. EVs released from MSCs contain various growth factors and cytokines with anti-inflammatory effects in the skin immune response. Here, we summarize and discuss the progress to date in targeted therapies that immunomodulate the niche environment of vitiligo, from the clinical trial of JAK inhibitors to the potential of MSCs and MSC-EVs. The available information was collected to highlight the need for further research into the treatment of vitiligo.
Cysteine-Rich Secretory Proteins (CRISP) are Key Players in Mammalian Fertilization and Fertility
Authors: Gonzalez Soledad N. , Sulzyk Valeria , Weigel Muñoz Mariana , Cuasnicu Patricia S.
Published: December 2021

Mammalian fertilization is a complex process involving a series of successive sperm-egg interaction steps mediated by different molecules and mechanisms. Studies carried out during the past 30 years, using a group of proteins named CRISP (Cysteine-RIch Secretory Proteins), have significantly contributed to elucidating the molecular mechanisms underlying mammalian gamete interaction. The CRISP family is composed of four members (i.e., CRISP1-4) in mammals, mainly expressed in the male tract, present in spermatozoa and exhibiting Ca2+channel regulatory abilities. Biochemical, molecular and genetic approaches show that each CRISP protein participates in more than one stage of gamete interaction (i.e., cumulus penetration, sperm-ZP binding, ZP penetration, gamete fusion) by either ligand-receptor interactions or the regulation of several capacitation-associated events (i.e., protein tyrosine phosphorylation, acrosome reaction, hyperactivation, etc.) likely through their ability to regulate different sperm ion channels. Moreover, deletion of different numbers and combination ofCrispgenes leading to the generation of single, double, triple and quadruple knockout mice showed that CRISP proteins are essential for male fertility and are involved not only in gamete interaction but also in previous and subsequent steps such as sperm transport within the female tract and early embryo development. Collectively, these observations reveal that CRISP have evolved to perform redundant as well as specialized functions and are organized in functional modules within the family that work through independent pathways and contribute distinctly to fertility success. Redundancy and compensation mechanisms within protein families are particularly important for spermatozoa which are transcriptionally and translationally inactive cells carrying numerous protein families, emphasizing the importance of generating multiple knockout models to unmask the true functional relevance of family proteins. Considering the high sequence and functional homology between rodent and human CRISP proteins, these observations will contribute to a better understanding and diagnosis of human infertility as well as the development of new contraceptive options.