bluuebunny/crossref_metadata_2025 huggingface dataset:
The Compounding Effect: How Co-Offending Exacerbates the Harm Caused by Violent Offenders
Authors: Piper Emily , Ariel Barak , Harinam Vincent , Bland Matthew
Published: May 2024

To what extent do violent offenders cause harm to victims when they act independently versus when they collaborate with others? Currently, it remains unclear whether co-offending exacerbates the degree of violence, partly due to measurement considerations, i.e. how to account for varying degrees of crime severity. Using police records from Dorset, UK, we compare violent crimes committed by lone individuals to those committed by co-offending networks using a crime harm index. While lone offenders commit the majority of violent acts, those with multiple connections to other violent offenders yielded higher average and total harm scores. Moreover, the severity of offences is proportional to the scale of the criminal network, with larger violent networks linked to higher crime harm scores. Finally, the propensity for recidivism is greater among co-offender groups compared to lone offenders. The implications of the compounding effect of co-offending on violence are discussed.
A detailed review of the spinal accessory nerve and its anatomical variations with cadaveric illustration
Authors: Roberts Siôn Owain , Cardozo Arun
Published: May 2024

The spinal accessory nerve, considered part of the eleventh cranial nerve, provides motor innervation to sternocleidomastoid and trapezius. A comprehensive literature review and two cadaveric dissections were undertaken. The spinal accessory nerve originates from the spinal accessory nucleus. Its rootlets unite and ascend between the denticulate ligament and dorsal spinal rootlets. Thereafter, it can anastomose with spinal roots, such as the McKenzie branch, and/or cranial roots. The spinal accessory nerve courses intracranially via foramen magnum and exits via jugular foramen, within which it usually lies anteriorly. Extracranially, it usually crosses anterior to the internal jugular vein and lies lateral to internal jugular vein deep to posterior belly of digastric. The spinal accessory nerve innervates sternocleidomastoid, receives numerous contributions in the posterior triangle and terminates within trapezius. Its posterior triangle course approximates a perpendicular bisection of the mastoid-mandibular angle line. The spinal accessory nerve contains sensory nociceptive fibres. Its cranial nerve classification is debated due to occasional non-fusion with the cranial root. Surgeons should familiarize themselves with the variable course of the spinal accessory nerve to minimize risk of injury. Patients with spinal accessory nerve injuries might require specialist pain management.
Validation of a simplified small-scale DNA extraction protocol from wine by quantitative real-time PCR
Authors: Scali Monica , Spinsanti Giacomo , Vignani Rita
Published: May 2024

In the present study, we compared a simplified small-scale purification protocol to obtain DNA admixtures out of wine, with our large-scale published method. The extraction methods must provide DNA free of PCR inhibitors, that can interfere with DNA amplification. To evaluate the efficiency of grapevine’s nuclear DNA extraction from wine, the new protocol was also compared in terms of purity and yield to the DNA obtained out of grapevine’s (Vitis vinifera) leaf tissue, using a commercial kit. Two single-copy nuclear genes, nine-cis-epoxy carotenoid dioxygenase 2 (NCED2), and prefoldin subunit 5-like (PS5) were amplified in DNA extracted from wine and grapevine by real-time TaqMan PCR to determine the presence of inhibitors in relation to the diversity of starting biological matrix. This study showed that the small-scale, simpler method for extracting DNA from wine produced effective results in terms of inhibitor presence and purity. Furthermore, even though the initial biological matrix was more complicated, the grapevine nuclear DNA that was removed from wine was qualitatively equivalent to the DNA that was isolated from the leaves.
A very-low-calorie ketogenic diet normalises obesity-related enhanced levels of erythropoietin compared with a low-calorie diet or bariatric surgery
Authors: Fernandez-Pombo A. , Lorenzo P. M. , Carreira M. C. , Gomez-Arbelaez D. , Castro A. I. , Primo D. , Rodriguez J. , Sajoux I. , Baltar J. , de Luis D. , Bellido D. , Crujeiras A. B. , Casanueva F. F.
Published: May 2024

Purpose

Nutritional ketosis synergistically with body-weight loss induced by a very-low-calorie ketogenic diet (VLCKD) has proven to be effective in improving obesity-related pathophysiology. Recently, growing attention has been focused on the relation between erythropoietin (EPO) and obesity. Thus, this study aims to investigate whether nutritional ketosis and weight loss induced by a VLCKD modify the circulating levels of EPO in patients with obesity in comparison with the effect of low-calorie diet (LCD) or bariatric surgery (BS).

Methods

EPO levels, iron status and body composition parameters were evaluated in 72 patients with overweight or obesity and 27 normal-weight subjects at baseline and after the three different weight-reduction therapies (VLCKD, LCD and BS) in 69 patients with excess body weight. β-hydroxybutyrate levels were also measured in the VLCKD group. The follow-up was established at 2–3 months and 4–6 months.

Results

It was found that EPO levels were higher in morbid obesity and correlated with higher basal weight, fat mass (FM) and fat-free mass (FFM) in the overall sample. High baseline EPO levels were also correlated with higher impact on the course of weight loss and changes in FM and FFM induced by the three weight-loss interventions. Furthermore, the VLCKD induced a decrease in EPO levels coinciding with maximum ketosis, which was maintained over time, while statistically significant changes were not observed after LCD and BS.

Conclusion

The obesity-related increased EPO levels are restored after VLCKD intervention at the time of maximum ketosis, suggesting a potential role of the nutritional ketosis induced by the VLCKD. Baseline EPO levels could be a biomarker of response to a weight-loss therapy.

Graphical abstract
Innovation in Healthcare Education: Using “Shark Tank” Approaches to Educate Teams of Interprofessional Students in Health Equity
Authors: Adepoju Omolola E. , Tipton Mary E. , Gilbert Lauren R.
Published: May 2024

Inspired by the television show Shark Tank, we developed a summer research program that brought together students from the Colleges of Medicine, Pharmacy, Business, and Communications, to collaborate, find creative solutions, and spark innovations in population health. Under the guidance of faculty, student teams conducted literature reviews and data-thon exercises to examine trends to identify health equity gaps. Students then worked collaboratively to develop and pitch innovative solutions in front of a panel of expert “sharks” for feedback and to gain financial support to advance their ideas.
Additive Manufacturing of Sensors: A Comprehensive Review
Authors: Hossain Md Jarir , Tabatabaei Bahareh Tavousi , Kiki Mazen , Choi Jae-Won
Published: May 2024

The  development and manufacturing of sensors are of great importance to modern engineering, as sensors are essential for detecting environmental changes and for the monitoring of various systems. While conventional manufacturing is the most common method for fabricating sensors, additive manufacturing (commonly known as 3D printing) has gained popularity as an efficient alternative. Although additively manufactured sensors are applicable in many engineering fields, building an entire sensor (including the housing structure and sensing components) by additive manufacturing remains challenging. This work presents a comprehensive analysis of the additive manufacturing processes, materials, and applications for sensors that are either fully or partially produced by additive manufacturing. Key issues in material development and processes that limit the development of fully 3D-printed sensors are highlighted. Additionally, the role of additively manufactured sensors plays in green technology has been explored. This review is expected to provide the researchers with a comprehensive understanding of the processes and materials used to produce sensors for various applications.
Textured Perovskite/Silicon Tandem Solar Cells Achieving Over 30% Efficiency Promoted by 4-Fluorobenzylamine Hydroiodide
Authors: Liu Jingjing , Shi Biao , Xu Qiaojing , Li Yucheng , Li Yuxiang , Liu Pengfei , SunLi Zetong , Wang Xuejiao , Sun Cong , Han Wei , Li Diannan , Wang Sanlong , Zhang Dekun , Li Guangwu , Du Xiaona , Zhao Ying , Zhang Xiaodan
Published: May 2024

Monolithic textured perovskite/silicon tandem solar cells (TSCs) are expected to achieve maximum light capture at the lowest cost, potentially exhibiting the best power conversion efficiency. However, it is challenging to fabricate high-quality perovskite films and preferred crystal orientation on commercially textured silicon substrates with micrometer-size pyramids. Here, we introduced a bulky organic molecule (4-fluorobenzylamine hydroiodide (F-PMAI)) as a perovskite additive. It is found that F-PMAI can retard the crystallization process of perovskite film through hydrogen bond interaction between F− and FA+ and reduce (111) facet surface energy due to enhanced adsorption energy of F-PMAI on the (111) facet. Besides, the bulky molecular is extruded to the bottom and top of perovskite film after crystal growth, which can passivate interface defects through strong interaction between F-PMA+ and undercoordinated Pb2+/I−. As a result, the additive facilitates the formation of large perovskite grains and (111) preferred orientation with a reduced trap-state density, thereby promoting charge carrier transportation, and enhancing device performance and stability. The perovskite/silicon TSCs achieved a champion efficiency of 30.05% based on a silicon thin film tunneling junction. In addition, the devices exhibit excellent long-term thermal and light stability without encapsulation. This work provides an effective strategy for achieving efficient and stable TSCs.
Rheological properties of high-performance SCC using recycled marble powder
Authors: Shawki Maha Ahmed , Elnemr Amr , Koenke Carsten , Thomas Carlos
Published: May 2024

Due to the impacts of cement manufacturing and depletion of the natural aggregates for concrete production, recycling of construction and demolition waste materials has become an alternative replacement to natural materials that lower their consumption and satisfy the environment. One of these alternatives is replacing cement with recycled materials from marble, ceramic, granite, and concrete wastes or even replacing the coarse aggregate with crushed marble and other stone wastes. Marble, granite, and natural stone wastes rapidly increase each year due to unmanaged waste disposal processes and the incremental increase in construction potential. Marble slurry, which comes from washing and cleaning marble surfaces, shows a filler effect by giving the concrete a denser and homogenous structure. This study evaluates the marble filler effects on the rheology in the fresh state of self-compacting concrete (SCC) through four SCC mixes by incorporating 10% marble powder (MP) and 33% fly ash (FA) as a partial ordinary Portland cement (OPC) replacement. Tests on paste and mortar were conducted to assess the suitability of the marble dosage on the water content and the superplasticizer amount. Spread flow and V-funnel tests were assessed. The results showed that mixes with MP required additional mixing water to ensure the same workability. Regardless of the high viscosity and air content, the overall developed marble SCC mixes reduced the cement quantity by up to 11% and provided excellent rheological properties like that of the reference mix. Besides the economic benefits, this transformation of waste to valuable materials involves environmental advantages and sustainability promotion.
Utilization of steel slag as partial replacement for coarse aggregate in concrete
Authors: Mitwally Mohamed Elwi , Elnemr Amr , Shash Ahmed , Babiker Ahmed
Published: May 2024

The utilization of steel slag for industrial and construction purposes has gained significant attention in recent years due to its abundant availability and potential environmental benefits. This study explores the feasibility of utilizing steel slag as a coarse aggregate in concrete, aiming to determine the optimal replacement percentages for desired mechanical and structural properties. Experimental investigations were conducted, substituting steel slag for conventional coarse aggregate in varying proportions. The concrete mixtures were tested for compressive strength, flexural strength, workability, and other parameters. The results demonstrate the promising potential of incorporating steel slag as a partial replacement for coarse aggregate. The mixture with 30% steel slag replacement exhibited favorable strength properties and workability. Both compressive and flexural strengths showed significant improvement, highlighting the viability of steel slag as an alternative to conventional coarse aggregate. The findings provide valuable guidance for engineers, researchers, and decision-makers in the construction industry regarding the practical benefits and considerations of using steel slag in concrete mixtures. This utilization promotes resource efficiency, reduces environmental impact, and maintains or enhances the mechanical and workability properties of concrete.
Impact of different irrigation & trace metals treatments on onion (Allium cepa L.) plant growth cultivated in rural and urban soils
Authors: Angelaki Anastasia , Golia Evangelia E.
Published: May 2024

The present research attempts to evaluate the response ofAllium cepa L.to different irrigation treatments and to indicate the optimum scheme along with plant growth, throughout a pot experiment during Spring 2021. The experimental procedure consisted of two different soil types, three treatments of irrigation and two levels of Cu and Zn (low and high), in four replications each. Irrigation events started when the lower allowable limit (LAL) reached a defined percentage of filed capacity (FC): 40% FC, 60% FC, and 75% FC and an irrigation event occurred with irrigation doses (Dn) equal to 60% FC, 40% FC, and 25% FC, respectively, to reach the value of FC. According to the results, the minimum yield was achieved by both soil types when Cu and Zn solution concentration and water stress were at their highest levels, although light texture soil (loamy sand—LS) allowed for superior growth. The optimum scheme was: the lower concentration of Cu and Zn solution along with LAL equal to 60% FC at the loamy sand soil. The outcomes suggest that frequent short irrigation doses at light-texture soils can result in yield response indicators when planted in pots. Furthermore, the influence of Cu and Zn cations at low concentrations can be advantageous for onions because Cu cations provide protection against fungal diseases, while Zn cations serve as nutrient support reducing the risk of metals deficiency.
Interventions to Reduce Child Maltreatment: A Systematic Review with a Narrative Synthesis
Authors: Malmberg-Heimonen Ira , Finne Joakim , Tøge Anne Grete , Pontoppidan Maiken , Dion Jacinthe , Tømmerås Truls , Pedersen Eirin
Published: May 2024

Child maltreatment has been a prominent topic on the political agenda for the past decade. However, while there are several types of interventions that can potentially benefit the prevention of child maltreatment, uncertainties remain regarding the transferability of these interventions to different contexts and their overall impact. Consequently, we conducted a systematic review of intervention studies aimed at preventing child maltreatment. We searched for studies published between 2016 and 2021, using predefined keywords from various bibliographical databases including PsycINFO, SocINDEX, Social Care Online, Web of Science, and ASSIA. The initial literature search yielded 3221 studies based on titles and abstracts, after removing duplicates. Out of these, 251 studies were screened based on full texts, resulting in the selection of 56 studies that met our inclusion criteria and were retained for extraction and analysis. The screening and data extraction processes were conducted by at least two independent reviewers. Given the heterogeneity of the included studies, we performed a narrative synthesis and categorized the 56 studies based on intervention type, control condition, outcomes, effects and quality. The results indicated that most of the studies employed individual randomization, with the control group most often receiving treatment as usual. Home visiting programs and educational interventions emerged as the most prevalent types of interventions. The review also demonstrated that a significant number of the included studies reported positive effects on one or more outcomes, such as indicators of maltreatment, suboptimal parenting practices, and problematic child behaviors. While nearly one-third of the studies did not report an effect size, those that did reported varying types of effect sizes. Additionally, only a few studies met the assessed quality criteria.
A versatile immunoassay based on functionalized nanoparticles for botulinum neurotoxin detection and sensor development
Authors: Nguyen Hong-Loan T. , Nguyen Huong-Ly , Le Phan-Anh , Nguyen Thanh-Trung , Luu Manh-Quynh , Pham Yen
Published: May 2024

Botulinum neurotoxins (BoNTs) serotypes A and B are the two most common of the four BoNTs that cause the high mortality botulism disease in individuals consuming contaminated foods. The gold standard assay for BoNT detection is the live mouse bioassay, which has several major disadvantages, including tedious procedures and animal sacrifice requirements. In this study, we developed an immuno-based assay using magnetic streptavidin nanoparticles (mSNP) functionalized with specific synthetic biotinylated, 6xHis-tagged peptide substrates (Peptides A, PA and B, PB) designed for BoNT/A and BoNT/B proteolytic reactions, respectively. In the presence of active toxins that possess endopeptidase activity, upon cleavage, the released fragments with His-tag were dotted on a blotting membrane, ultimately producing color signals after incubation with anti-His antibody, alkaline phosphatase (AP)-conjugated antibody, and then AP substrates. The results showed that the efficiency of peptide-mSNP complex formation reached up to 81%, and the dot blot immunoassay allowed peptide detection from 10 ng of His-tagged peptides. Preliminary testing with the extracellular extracts from the isolated Clostridium botulinum strains indicated that the botulinum toxin in the 2020 botulism outbreak in Vietnam belonged to serotype A, the most potent BoNT. The established assay could be applied to construct a portable biosensor for BoNT detection and a high throughput device to screen potential BoNT inhibitors for drug development.
EcoSonicML: Harnessing Machine Learning for Biodiversity Monitoring in South African Wetlands
Authors: Nel Harry , Mishra Amit Kumar , Schonken Francois
Published: May 2024

Biodiversity monitoring, particularly in a country as diverse as South Africa with its extensive migratory bird population, presents significant challenges. This challenge becomes even more pronounced in environments with a multitude of coexisting bird species, notably wetlands, which serve as crucial breeding and feeding grounds for various avian species. This research will address this challenge by designing a cost-effective sound-based sensor system capable of deployment in diverse wetland ecosystems. The primary aim is to aid in the monitoring of bird species by detecting their presence and distribution and then transmitting this valuable data to a central base station. To assess the system’s feasibility and performance, a series of experiments were conducted at the Rondevlei Nature Reserve in Cape Town, South Africa. These experiments focused on the sensor’s capacity to accurately identify avian species while maintaining robustness in varying environmental conditions. The results yielded promising outcomes, demonstrating the successful identification of bird species. Furthermore, the system exhibited reliability across different weather conditions, positioning it as a viable choice for long-term deployment in wetland environments. Beyond species detection, this project also delved into practical aspects of data transfer and storage efficiency, ensuring the system’s suitability for real-world applications. Modularity was another crucial consideration, simplifying maintenance and upgrades. Moreover, a preliminary cost analysis indicated the cost-effectiveness of the system compared to commercial alternatives. The integration of climate sensors into the monitoring system was explored as a future direction. This addition holds the potential to provide a more comprehensive approach to environmental monitoring by incorporating climate data into the analysis. Such a holistic approach can further enrich our understanding of bird behaviour in relation to changing environmental conditions. The findings of this research have significant implications for avian conservation and ecological studies, particularly in the unique context of South Africa. This project introduces an affordable and practical tool for monitoring bird species in wetland habitats, offering valuable insights into the preservation and management of these critical ecosystems.
Response of Moisture and Temperature Diffusivity on an Orthotropic Hygro-thermo-piezo-elastic Medium
Authors: Gupta Vipin , Barak M. S. , Ahmad Hijaz , Das Soumik , Almohsen Bandar
Published: May 2024

This research explores the complex interaction between piezoelectric waves and heat-moisture diffusion within a semi-infinite piezoelectric material under hygro-thermal conditions. By employing a two-dimensional Cartesian framework, novel governing equations for a thermo-piezoelectrically orthotropic medium influenced by moisture effects are developed. Accurate representations for key parameters are obtained by utilizing normal mode analysis. The investigation examines the influence of critical factors like moisture content, diffusivity, and temperature diffusivity on the spatial distribution of various physical fields. Additionally, a particular scenario of significance is highlighted. These results have the potential to improve sensor, actuator, and energy-harvesting device performance and dependability.
Infection prevention and control compliance during COVID-19 pandemic era: assessment of 26 regional referral hospitals in Tanzania
Authors: Bahegwa Radenta P. , Hokororo Joseph. C. , Msigwa Yohanes S. , Ngowi Ruth R. , German Chrisogone J. , Marandu Laura , Nasoro Omary A. , Kinyenje Erick S. , Degeh Mbwana M. , Masuma Janeth S. , Lutkam Doris S. , Eliakimu Eliudi S.
Published: May 2024

Background

Infection prevention and control (IPC) implementation at referral hospitals (RHs) in Tanzania is still inadequate, regardless of ongoing IPC capacity-building initiatives. This continues to challenge the quality of healthcare service provision as poor IPC implementation fuels healthcare-associated infections (HAIs) and antimicrobial resistance (AMR) problems. The study aimed to describe the implementation of IPC practices in 26 Regional RHs’ functional units in 2021.

Methods

The study involved secondary data from an assessment conducted using the National IPC Standard checklist for hospitals to all functional units at 26 regional RHs in 2021. Data were analysed in STATA version 15.0 to compute the weighted median with interquartile range (IQR) for each functional unit score.

Results

The overall weighted median IPC compliance with 26 regional RHs in 2021 was 50 (41–60), whereby the lowest and highest scores were 24 and 72%, respectively. The highest-performing unit was the intensive care unit (ICU) for adults 71.4% (46.4–78.6), and lowest performing functional units were the mortuary, Central Sterilization and Supply Department, and blood transfusion [47.4% (36.8–57.9), 47.4% (40–50), and 47.6% (38.1–61.9)], respectively.

Conclusion

Implementation of IPC practices in 26 RHs in Tanzania is inadequate. We recommend that RHs need to strengthen IPC practices implementation in each functional unit in order to reach the required target of at least 80% score. This will enhance the reduction of the burden of HAIs and AMR, and increase the energy and morale of healthcare workers in preparedness and response to emerging and remerging diseases.
Towards Game Translation User Research
Authors: Deckert Mikołaj , Bernal-Merino Miguel Ángel , Hejduk Krzysztof
Published: May 2024

This Element takes the initiative to highlight the nascent state of audiovisual translation research centring on users of video games. It proposes ways of advancing the research by integrating numerous related perspectives from relevant fields to guide studies in translated game reception into further fruition. The Element offers an accessible overview of possible relationships between translation and its experiencers, showcasing ways to design game reception studies. Examples, methods, tools, and practical concerns are discussed to ultimately develop a blueprint for game translation user research which aims to consolidate scientific user-centric inquiry into video game translation. To that end, the blueprint captures the three-pronged interplay between the parameters of localisation-reception research in facets of user experience, facets of translated games, and facets of game users.
Re-Understanding Entrepreneurship
Authors: Zhang Weiying
Published: May 2024

How do entrepreneurs make decisions in the real world? Why are entrepreneurs absent from mainstream economics? What functions do entrepreneurs play in the market? What type of institutional environment is needed for entrepreneurship to play a role? Neoclassical economics is a market theory without entrepreneurship. This misconception distorts our understanding of how the real market works, leading to a theory of market failure that forms the common foundation of various government interventions. The market is not only an allocative process but, more importantly, a discovery and creative process. To understand the real market, Weiying Zhang argues that economics must shift from a price-centric to an entrepreneur-centric paradigm. Blending theory and narrative, Zhang intersects history with the present supporting his theory with relevant case studies. He argues that once entrepreneurship in the market is correctly understood, the foundation for government intervention is undermined and the economy can sustainably flourish.
Successful reduction of urinary catheter placement for correct and incorrect indications after introduction of a prevention bundle
Authors: Cipriani Michela , Schlegel Matthias , Schwark-Bähler Marianne , Henz Samuel , Kohler Philipp , Albrich Werner C.
Published: May 2024

The prospective before-after quality improvement study was to assess bundle effectiveness to reduce urinary catheter days and prevent associated complications. All patients with preexisting or new urinary catheters in a regional hospital in Switzerland were included. We showed a reduction of catheter days, incorrect urinary catheter indications, and most strikingly formally correct indications.
Understanding older adults' travel behaviour and mobility needs during the COVID-19 pandemic through the lens of the hierarchy of travel needs: a systematic review
Authors: Yazdanpanahi Melisa , Pantelaki Evangelia , Holland Carol , Gilroy Rose , Spencer Ben , Weston Richard , Rogers Allyson
Published: May 2024

The aim of this article is to critically review the scientific literature about the changes in travel behaviour and mobility amongst older adults caused by the COVID-19 pandemic across various countries, identify unmet travel needs and highlight patterns of inequalities in older adults' mobility. We have collected articles from four academic databases: PubMed, Scopus, Transportation Research International Documentation (TRID) and Web of Science. Papers were considered for inclusion if they were published online in 2020 or later, written in English, and referred to urban or rural changes in travel behaviour and mobility of older adults over 50 years old. We examined the pre-existing models developed before the outbreak and classified the articles based on Musselwhite and Haddad's hierarchy of older adults' travel needs. The synthesis of the selected 25 articles shows a general decline in literal mobility amongst older adults, an increased share of virtual travel and their decreased capacity to fulfil different levels of travel needs. Findings also indicate an increased gap in older adults' mobility across geographical regions with various levels of transport infrastructure and digital capital. We conclude the paper with the lessons learned, the opportunities ahead, and the challenges that must be overcome to achieve sustainable development and the United Nations Decades of Healthy Ageing goals in the post-pandemic world.
Emotion regulation across psychiatric disorders
Authors: Aslan Ibrahim H. , Dorey Lucy , Grant Jon E. , Chamberlain Samuel R.
Published: May 2024

Objective

Difficulties with emotion regulation have been associated with multiple psychiatric conditions. In this study, we aimed to investigate emotional regulation difficulties in young adults who gamble at least occasionally (ie, an enriched sample), and diagnosed with a range of psychiatric disorders using the validated Difficulties in Emotion Regulation Scale (DERS).

Methods

A total of 543 non-treatment-seeking individuals who had engaged in gambling activities on at least 5 occasions within the previous year, aged 18–29 were recruited from general community settings. Diagnostic assessments included the Mini International Neuropsychiatric Inventory, Minnesota Impulsive Disorders Interview, attention-deficit/hyperactivity disorder World Health Organization Screening Tool Part A, and the Structured Clinical Interview for Gambling Disorder. Emotional dysregulation was evaluated using DERS. The profile of emotional dysregulation across disorders was characterized using Z-scores (those with the index disorder vs. those without the index disorder).

Results

Individuals with probable ADHD displayed the highest level of difficulties in emotional regulation, followed by intermittent explosive disorder, social phobia, and generalized anxiety disorder. In contrast, participants diagnosed with obsessive-compulsive disorder showed relatively lower levels of difficulties with emotional regulation.

Conclusions

This study highlights the importance of recognizing emotional dysregulation as a trans-diagnostic phenomenon across psychiatric disorders. The results also reveal differing levels of emotional dysregulation across diagnoses, with potential implications for tailored treatment approaches. Despite limitations such as small sample sizes for certain disorders and limited age range, this study contributes to a broader understanding of emotional regulation’s role in psychiatric conditions.
Multi-Shot Answer Set Programming for Flexible Payroll Management
Authors: CALLEWAERT BENJAMIN , VENNEKENS JOOST
Published: May 2024

Payroll management is a critical business task that is subject to a large number of rules, which vary widely between companies, sectors, and countries. Moreover, the rules are often complex and change regularly. Therefore, payroll management systems must be flexible in design. In this paper, we suggest an approach based on a flexible answer set programming (ASP) model and an easy-to-read tabular representation based on the decision model and notation standard. It allows HR consultants to represent complex rules without the need for a software engineer and to ultimately design payroll systems for a variety of different scenarios. We show how the multi-shot solving capabilities of the clingo ASP system can be used to reach the performance that is necessary to handle real-world instances.
Einflussfaktoren bei der Implementierung von Expertenstandards in der Pflege
Authors: Niemann Lea-Maria , Gruber Eva Maria , Büscher Andreas
Published: May 2024

Zusammenfassung: Hintergrund: Viele deutsche Gesundheits- und Pflegeeinrichtungen stehen vor der Herausforderung, Expertenstandards in der Praxis zu implementieren. Implementierungsmodelle, wie das Consolidated Framework for Implementation Research (CFIR), unterstützen den Implementierungsprozess, indem sie die relevanten Einflussfaktoren identifizieren, die den Erfolg einer Implementierung bestimmen können. Ziel: Ziel war es, die Einflussfaktoren auf die Implementierung von Expertenstandards in der Pflege und deren Wechselwirkungen zu identifizieren. Methode: Die Datenerhebung erfolgte mittels leitfadengestützter Interviews mit zehn Projektbeauftragten der modellhaften Implementierung des Expertenstandards zur Förderung der Mundgesundheit in der Pflege sowie über Projektverlaufsdokumentationen. Die Daten wurden inhaltsanalytisch ausgewertet. Ergebnisse: Neben den Einflussfaktoren nach dem CFIR konnten zwei weitere Faktoren identifiziert werden, die den Erfolg in der Implementierung von Expertenstandards bestimmen können – die Präsenz vor Ort und Kenntnisse von Implementierungstheorien und -modellen. Deutlich wurden vor allem die verschiedenen und komplexen Zusammenhänge der Faktoren in der Implementierung von Expertenstandards. Schlussfolgerung: Für die erfolgreiche und nachhaltige Implementierung von Expertenstandards sowie für den generellen Wissenstransfer in der Pflege sind Kenntnisse der Implementierungsmodelle hilfreich.
Secular Changes in the Occurrence of Subduction During the Archean
Authors: Liu Chun‐Tao , Ye Chen‐Yang , ZhangZhou J.
Published: May 2024

Subduction processes play a pivotal role in facilitating material exchange between the crust and mantle, contributing to the growth of continents. However, the onset and evolution of subduction remain hotly debated. Here, we developed a high‐dimensional machine learning (ML) model to use multiple compositional data (e.g., Nb/La, Nb, Ti, Nb/U, Pb/Nd, and Nb/Th) to distinguish arc‐type from non‐arc basalts worldwide, then applied this well‐trained ML model to identify and delineate the secular occurrence of Archean arc‐type basalts. Our findings indicate that basaltic arc magmatism can be traced back to only a few early Archean cratons. A noticeable increase in the prevalence of arc‐type basalts during the Mesoarchean and Neoarchean suggests the synchronous formation of Archean subduction across different cratons. This observation hints at transitioning from the predominantly stagnant geodynamic regime to the early, more mobile tectonic regime.
Mechanically Controlled Landslide Deformation
Authors: Pudasaini Shiva P. , Mergili Martin
Published: May 2024

Many landslide models assume a fully deformable body without any resistance against deformation. However, in reality, landslide bodies can display negligible to large deformation during motion. Examples for limited deformation include the prehistoric giant landslides of Flims and Köfels, or the Vajont landslide of 1963, where the structure of rock largely remained intact and the slides did not evolve into rock avalanches. Here, we propose a novel mechanical model for the controlled deformation of landslides. The model is based on the principle of material strength or resistance and includes a user‐specified function that reflects the mechanisms (internal friction, cohesion, viscosity, and yield strength) that act against the deformation induced by the free‐surface or the hydraulic pressure gradient of the landslide. This controls the landslide deformation and, in turn, also the motion and run‐out, and offers a unique possibility to describe the landslide motion ranging from a fully non‐deformable body sliding along the mountain slope to a completely fluidized motion without any resistance against the force associated with the free‐surface pressure gradient. The latter is the situation often considered for the motion of granular flows such as avalanches of snow or rock, or debris flows. The former can play a substantial role in the dynamics, however, has not yet been considered in mass flow simulations, severely limiting the applicability of those models. We demonstrate the performance of the new model and its applicability, also with the advanced open‐source computational mass flow simulation tool r.avaflow.
Hypertension in sub-Saharan Africa: the current profile, recent advances, gaps, and priorities
Authors: Gafane-Matemane Lebo F. , Craig Ashleigh , Kruger Ruan , Alaofin Omotayo S. , Ware Lisa J. , Jones Erika S. W. , Kengne Andre Pascal
Published: May 2024

Recent global and regional reports consistently confirm the high and increasing prevalence of hypertension in sub-Saharan Africa (SSA), with poor detection, treatment, and control rates. This narrative review summarises the burden of hypertension in SSA and recent findings from community-based hypertension management strategies. We further outline prominent risk factors according to recent data and associated underlying mechanisms for hypertension development. An extensive review of literature showed that most countries have reported on the prevalence of hypertension during 2017–2023, despite limitations linked to the lack of nationally representative studies, heterogeneity of sampling and data collection methods. Task-shifting approaches that assign roles to model patients and community health workers reported improved linkage to healthcare services and adherence to medication, with inconsistent findings on blood pressure (BP)-lowering effects over time. The regularly reported risk factors include unhealthy diet, sedentary lifestyle, increased adiposity and underweight, ageing, level of education, and/or income as well as psychosocial factors. Newer data on the pathophysiological mechanisms leading to hypertension and potential areas of intervention are reported from children and adults and include, among others, salt-handling and volume overload, endothelial function, BP dipping patterns and the role of human immunodeficiency virus . To conclude, significant strides have been made in data reporting from SSA on the burden of hypertension in the region as well as biomarker research to improve understanding and identification of areas of intervention. However, gaps remain on linkage between knowledge generation, translation, and implementation research. Coordinated studies addressing both discovery science and public health are crucial to curb hypertension development and improve management in SSA.
The spectrum of pneumonia among intubated neonates in the neonatal intensive care unit
Authors: Bondarev Dayle J. , Ryan Rita M. , Mukherjee Devashis
Published: May 2024

We review the pathophysiology, epidemiology, diagnosis, treatment, and prevention of ventilator-associated pneumonia (VAP) in neonates. VAP has been studied primarily in adult ICU patients, although there has been more focus on pediatric and neonatal VAP (neo-VAP) in the last decade. The definition as well as diagnosis of VAP in neonates remains a challenge to date. The neonatal intensivist needs to be familiar with the current diagnostic tools and prevention strategies available to treat and reduce VAP to reduce neonatal morbidity and the emergence of antibiotic resistance. This review also highlights preventive strategies and old and emerging treatments available.
Novel FOXM1 inhibitor STL001 sensitizes human cancers to a broad-spectrum of cancer therapies
Authors: Raghuwanshi Sanjeev , Zhang Xu , Arbieva Zarema , Khan Irum , Mohammed Hisham , Wang Z. , Domling Alexander , Camacho Carlos Jaime , Gartel Andrei L.
Published: May 2024

Forkhead box protein M1 (FOXM1) is often overexpressed in human cancers and strongly associated with therapy resistance and less good patient survival. The chemotherapy options for patients with the most aggressive types of solid cancers remain very limited because of the acquired drug resistance, making the therapy less effective. NPM1 mutation through the inactivation of FOXM1 via FOXM1 relocalization to the cytoplasm confers more favorable treatment outcomes for AML patients, confirming FOXM1 as a crucial target to overcome drug resistance. Pharmacological inhibition of FOXM1 could be a promising approach to sensitize therapy-resistant cancers. Here, we explore a novel FOXM1 inhibitor STL001, a first-generation modification drug of our previously reported FOXM1 inhibitor STL427944. STL001 preserves the mode of action of the STL427944; however, STL001 is up to 50 times more efficient in reducing FOXM1 activity in a variety of solid cancers. The most conventional cancer therapies studied here induce FOXM1 overexpression in solid cancers. The therapy-induced FOXM1 overexpression may explain the failure or reduced efficacy of these drugs in cancer patients. Interestingly, STL001 increased the sensitivity of cancer cells to conventional cancer therapies by suppressing both the high-endogenous and drug-induced FOXM1. Notably, STL001 does not provide further sensitization to FOXM1-KD cancer cells, suggesting that the sensitization effect is conveyed specifically through FOXM1 suppression. RNA-seq and gene set enrichment studies revealed prominent suppression of FOXM1-dependent pathways and gene ontologies. Also, gene regulation by STL001 showed extensive overlap with FOXM1-KD, suggesting a high selectivity of STL001 toward the FOXM1 regulatory network. A completely new activity of FOXM1, mediated through steroid/cholesterol biosynthetic process and protein secretion in cancer cells was also detected. Collectively, STL001 offers intriguing translational opportunities as combination therapies targeting FOXM1 activity in a variety of human cancers driven by FOXM1.
Neutrophil extracellular traps promote invasion and metastasis via NLRP3-mediated oral squamous cell carcinoma pyroptosis inhibition
Authors: Zhai Rundong , Gong Zizhen , Wang Mengqi , Ni Zihui , Zhang Jiayi , Wang Mengyao , Zhang Yu , Zeng Fanrui , Gu Ziyue , Chen Xingyu , Wang Xiudi , Zhou Pengcheng , Liu Laikui , Zhu Weiwen
Published: May 2024

Neutrophil extracellular traps (NETs) are reticular structures composed of neutrophil elastase (NE), cathepsin G (CG) and DNA-histone enzyme complexes. Accumulating evidence has revealed that NETs play important roles in tumor progression, metastasis, and thrombosis. However, our understanding of its clinical value and mechanism of action in oral squamous cell carcinoma (OSCC) is limited and has not yet been systematically described. Here, we aimed to investigate the clinical significance of NETs in OSCC and the mechanisms by which they affect its invasive and metastatic capacity. Our results demonstrated that high enrichment of NETs is associated with poor prognosis in OSCC, and mechanistic studies have shown that NE in NETs promotes invasion and metastasis via NLRP3-mediated inhibition of pyroptosis in OSCC. These findings may provide a new therapeutic approach for OSCC.
Protecting the piglet gut microbiota against ETEC-mediated post-weaning diarrhoea using specific binding proteins
Authors: Jenkins Timothy Patrick , Ács Norbert , Arendrup Emma Wenzel , Swift Abbie , Duzs Ágnes , Chatzigiannidou Ioanna , Pichler Michael , Kittilä Tiia , Peachey Laura , Gram Lone , Canibe Nuria , Laustsen Andreas Hougaard , Brix Susanne , Thrane Sandra Wingaard
Published: May 2024

Post-weaning diarrhoea (PWD) in piglets presents a widespread problem in industrial pig production and is often caused by enterotoxigenic E. coli (ETEC) strains. Current solutions, such as antibiotics and medicinal zinc oxide, are unsustainable and are increasingly being prohibited, resulting in a dire need for novel solutions. Thus, in this study, we propose and evaluate a protein-based feed additive, comprising two bivalent heavy chain variable domain (VHH) constructs (VHH-(GGGGS)3-VHH, BL1.2 and BL2.2) as an alternative solution to manage PWD. We demonstrate in vitro that these constructs bind to ETEC toxins and fimbriae, whilst they do no affect bacterial growth rate. Furthermore, in a pig study, we show that oral administration of these constructs after ETEC challenge reduced ETEC proliferation when compared to challenged control piglets (1-2 log10 units difference in gene copies and bacterial count/g faeces across day 2–7) and resulted in week 1 enrichment of three bacterial families (Prevotellaceae (estimate: 1.12 ± 0.25, q = 0.0054), Lactobacillaceae (estimate: 2.86 ± 0.52, q = 0.0012), and Ruminococcaceae (estimate: 0.66 ± 0.18, q = 0.049)) within the gut microbiota that appeared later in challenged control piglets, thus pointing to an earlier transition towards a more mature gut microbiota. These data suggest that such VHH constructs may find utility in industrial pig production as a feed additive for tackling ETEC and reducing the risk of PWD in piglet populations.
Surface-dominated conductance scaling in Weyl semimetal NbAs
Authors: Kumar Sushant , Tu Yi-Hsin , Luo Sheng , Lanzillo Nicholas A. , Chang Tay-Rong , Liang Gengchiau , Sundararaman Ravishankar , Lin Hsin , Chen Ching-Tzu
Published: May 2024

Protected surface states arising from non-trivial bandstructure topology in semimetals can potentially enable advanced device functionalities in compute, memory, interconnect, sensing, and communication. This necessitates a fundamental understanding of surface-state transport in nanoscale topological semimetals. Here, we investigate quantum transport in a prototypical topological semimetal NbAs to evaluate the potential of this class of materials for beyond-Cu interconnects in highly-scaled integrated circuits. Using density functional theory (DFT) coupled with non-equilibrium Green’s function (NEGF) calculations, we show that the resistance-area RA product in NbAs films decreases with decreasing thickness at the nanometer scale, in contrast to a nearly constant RA product in ideal Cu films. This anomalous scaling originates from the disproportionately large number of surface conduction states which dominate the ballistic conductance by up to 70% in NbAs thin films. We also show that this favorable RA scaling persists even in the presence of surface defects, in contrast to RA sharply increasing with reducing thickness for films of conventional metals, such as Cu, in the presence of surface defects. These results underscore the potential of topological semimetals as future back-end-of-line (BEOL) interconnect metals.
PSFHS: Intrapartum ultrasound image dataset for AI-based segmentation of pubic symphysis and fetal head
Authors: Chen Gaowen , Bai Jieyun , Ou Zhanhong , Lu Yaosheng , Wang Huijin
Published: May 2024

During the process of labor, the intrapartum transperineal ultrasound examination serves as a valuable tool, allowing direct observation of the relative positional relationship between the pubic symphysis and fetal head (PSFH). Accurate assessment of fetal head descent and the prediction of the most suitable mode of delivery heavily rely on this relationship. However, achieving an objective and quantitative interpretation of the ultrasound images necessitates precise PSFH segmentation (PSFHS), a task that is both time-consuming and demanding. Integrating the potential of artificial intelligence (AI) in the field of medical ultrasound image segmentation, the development and evaluation of AI-based models rely significantly on access to comprehensive and meticulously annotated datasets. Unfortunately, publicly accessible datasets tailored for PSFHS are notably scarce. Bridging this critical gap, we introduce a PSFHS dataset comprising 1358 images, meticulously annotated at the pixel level. The annotation process adhered to standardized protocols and involved collaboration among medical experts. Remarkably, this dataset stands as the most expansive and comprehensive resource for PSFHS to date.