bluuebunny/crossref_metadata_2025 huggingface dataset:
Twarzą do tego co umyka. Przypadek fotografii „ukrytych matek" w projekcie artystycznym Lindy Fregni Nagler
Authors: Zarychta Anna
Published: November 2020

Autorka analizuje artystyczny projekt Lindy F. Nagler zatytułowany The Hidden Mother (2013). W szczególności omawia towarzyszącą wystawie publikację, w której zebrano ponad tysiąc fotografii. Wszystkie te obiekty poprzez nadany publikacji tytuł, jak i w kontekście zamieszczonych na końcu tekstów, zostały uznane za obrazy prezentujące „ukryte matki”. Podstawowe pytanie, jakie przyświecało podjętym w tekście artykułu rozważaniom, dotyczy tego, kogo nie-przedstawiają prezentowane fotografie? A także tego, w jaki sposób nadany wystawie i albumowi tytuł zawęził historyczny, społeczny i kulturowy kontekst odczytania prezentowanych obrazów, sprowadzając towarzyszące fotografiom dyskusje do kwestii roli i sytuacji matek na przełomie XIX i XX wieku oraz do technicznych trudności wykonania fotografii małych dzieci, koncentrując się jednocześnie przede wszystkim na swoistej „dziwaczności/ułomności” uzyskanego efektu wizualnego.
The Medium of the Present. Rauschenberg’s Displaced Method
Authors: Mościcki Paweł
Published: November 2020

The article is devoted to Robert Rauschenberg’s Thirty-Four Illustrations for Dante’s ‘Inferno’ from 1958-1960. Instead of focusing on the allegorical or symbolic aspects of this project, the author tries to analyze the historicity that stems from the artist’s specific method – or as the article tries to prove: quasi-technique – of “solvent transfer” invented not long before the work on illustrations and developed during its realization. The article discusses this method in juxtaposition with two important contributions to the discussions about the importance of the artist’s technique for the understanding of his or her broader significance. The first is George Didi-Huberman’s book on the imprint as a prototype for anachronistic reflection on art, the second – Jacques Derrida’s essay on Antonin Artaud’s drawings and his practice of “unsensing the subjectile. While drawing upon those two texts the author of the article analyzes various aspects of temporality implicated in the method of solvent transfer and thus also in the project of Dante’s reading.
Archeologiczna proteza
Authors: Stobiecka Monika
Published: November 2020

Zabiegi konserwatorsko-rekonstrukcyjne prezentowane na wystawie w nowym muzeum Akropolu w Atenach zderzają ze sobą porządki materialności, wirtualności i technologii, oddając współczesny Zeitgeist — poszukiwanie kompletności i dążenie do całości, które nie przystają do sentymentalnej estetyki fragmentu. Proponuję w odniesieniu do zabiegu, dekonstrukcyjnego wobec tradycji muzealnictwa archeologicznego, wprowadzić kategorię archeologicznej protezy, która zawiąże wątki stojące na styku studiów nad materialnością, praktycznych wytycznych konserwatorstwa i zwrotu cyfrowego w archeologii. Archeologiczną protezę opisuję jako substytut, sztuczne uzupełnienie w miejscu straty lub braku. Archeologiczna proteza oznaczać będzie wyjście poza wizualny wymiar cyfrowych mediów w archeologii, zarazem stanowi materialny zabieg konserwatorski. Termin ten, pozwoli zastanowić się nad symbolicznym wyjściem wystaw rekonstrukcyjno-konserwatorskich poza „miękką” humanistykę archeologii i wkroczeniem w wymiar „twardej” nauki operującej w domenie mediów wirtualnych i materialnych interwencji konserwatorskich.
De-formations
Authors: Bojarska Katarzyna
Published: November 2020

Introduction to issue 24 "De-formations".
Douglas Crimp: A Farewell
Authors: Szcześniak Magda , Bojarska Katarzyna , Pijarski Krzysztof
Published: November 2020

A farewell to Douglas Crimp.
STUDY OF THE LIPID PIGMENT COMPOSITION IN THE WHITE SEA ALGAE SACCHARINA LATISSIMA USING TLC AND MALDI-MS
Authors: Krasnov К. А. , Gladchuk A. S. , Alexandrova M. L. , Keltsieva O. A. , Zaytseva M. A. , Melnikova M. V. , Reinyuk V. L. , Podolskaya Е. P.
Published: November 2020

The qualitative composition of the most important biologically active lipid substances-carotenoids and chlorophyll derivatives of the White sea algaeSaccharina latissimahas been studied. The lipid extract was separated by thin-layer chromatography (TLC) and examined by matrix-associated laser desorption-ionization with mass-spectrometric analysis (MALDI-MS). The extract contained fucoxanthin, fucoxanthinol, pheophytin a, pheophorbide a, as well as other carotenoids and chlorophylls, including those not described in the literature. The results obtained, which significantly expand the information about the composition of S. latissima pigments, can be used to standardize raw materials and preparations based on these algae.
Automated Transliteration of Late Egyptian Using Neural Networks: An Experiment in “Deep Learning”
Authors: Rosmorduc Serge
Published: November 2020

We apply Deep Learning techniques to the task of automated transliteration of Late Egyptian. After a brief presentation of the technology used, we examine the result to highlight the capabilities of the system, which is able to deal with a wide range of problems, including grammatical and phraseological ones. We then proceed to extract signs values from what the system has automatically learnt.
A fuzzy approach to multi-objective mixed integer linear programming model for multi-echelon closed-loop supply chain with multi-product multi-time-period
Authors: Akin Bas Sema , Ahlatcioglu Ozkok Beyza
Published: November 2020

By the green point of view, supply chain management (SCM), which contains supplier and location selection, production, distribution, and inventory decisions, is an important subject being examined in recent years by both practitioners and academicians. In this paper, the closed-loop supply chain (CLSC) network that can be mutually agreed by meeting at the level of common satisfaction of conflicting objectives is designed. We construct a multi-objective mixed-integer linear programming (MOMILP) model that allows decision-makers to more effectively manage firms’ closed-loop green supply chain (SC). An ecological perspective is brought by carrying out the recycling, remanufacturing and destruction to SCM in our proposed model. Maximize the rating of the regions in which they are located, minimize total cost and carbon footprint are considered as the objectives of the model. By constructing our model, the focus of customer satisfaction is met, as well as the production, location of facilities and order allocation are decided, and we also carry out the inventory control of warehouses. In our multi-product multi-component multi-time-period model, the solution is obtained with a fuzzy approach by using the min operator of Zimmermann. To illustrate the model, we provide a practical case study, and an optimal result containing a preferable level of satisfaction to the decision-maker is obtained.
Application of fuzzy programming techniques to solve solid transportation problem with additional constraints
Authors: Halder (Jana) Sharmistha , Jana Biswapati
Published: November 2020

An innovative, real-life solid transportation problem is explained in a non-linear form. As in real life, the total transportation cost depends on the procurement process or type of the items and the distance of transportation. Besides, an impurity constraint is considered here. The proposed model is formed with fuzzy imprecise nature. Such an interesting model is optimised through two different fuzzy programming techniques and fractional programming methods, using LINGO-14.0 tools followed by the generalized gradient method. Finally, the model is discussed concerning these two different methods.
Glabridin alleviates ischemia/reperfusion-induced functional failure of smooth
muscle of rat ileum by upregulating the cAMP
Authors:   University of
            Adiyaman, Parlar Ali , Çam Saliha Ayşenur ,   University of Ankara
            Yildirim Beyazit, Arslan Seyfullah Oktay ,   University of Ankara
            Yildirim Beyazit
Published: November 2020

Despite the development of modern medicine, alternative medicine, which has not
lost its timeliness, remains attractive for the treatment of various diseases.
Glabridin, a major flavonoid of Glycyrrhiza glabra, is known for its antioxidant and
anti-inflammatory activity. The aim of this study was: 1) to determine the possible
protective role of glabridin against ischemia/reperfusion (I/R) injury of the intestine;
2) to evaluate the in vitro contractile responses of ileum smooth muscles to
acetylcholine after an intestinal I/R; and 3) to explain the underlying molecular
mechanism of its effect. Rats were assigned to groups of six rats each; 1) I/R, 2)
gla10, 3) gla20, 4) gla40, 5) N5-[imino(nitroamino)methyl]-L-ornithine, methyl ester
monohydrochloride (L-NAME)+gla40, and 6) Sham group. The healing effect of glabridin was
abolished by L-NAME. Glabridin did not cause contractility of the smooth muscles to
acetylcholine-induced contractile responses in intestinal I/R. Yet, it increased to
spontaneous basal activity.
Lindera aggregata (Sims) Kosterm: Review on phytochemistry and biological
activities
Authors:   Universiti Pendidikan Sultan
            Idris, Salleh Wan Mohd Nuzul Hakimi Wan
Published: November 2020

The genus Lindera consists of approximately 100 species that are widely
distributed in tropical and subtropical areas throughout the world. Most Lindera plants,
particularly Lindera aggregata is a well-known traditional Chinese medicine that has
important medicinal value and health benefits. Contemporary chemical and pharmacological
studies have shown that L. aggregata are a source of structurally diverse molecules
having pharmacological potential. In an effort to promote research on L. aggregata and
develop therapeutic and pharmacological products, this review describes the structural
diversity of its components and pharmacological and biological significance of L.
aggregata. This review is based on a literature analysis of scientific journals from
electronic sources, such as Science Direct, PubMed, Google Scholar, Scopus and Web of
Science. Thus, with the growing interest in traditional medicine and botanical drugs
worldwide, L. aggregata will increasingly capture chemists’ and pharmacologists’
attention because they produce diverse and structurally novel compounds having
pharmacological significance.
Effect of encephalomyocarditis virus 3'Untranslated region on GFP transient
expression: implications in recombinant protein production
Authors:   Kermanshah University of Medical
            Sciences, Marzbany Marzieh , Rasekhian Mahsa ,   Kermanshah University of
            Medical Sciences
Published: November 2020

The enrichment of therapeutic protein production yield in mammalian cell cultures
by modulating mRNA stability is a fairly new strategy in biotechnological applications.
Here, we describe the application of 3′-untranslated region (3′UTR) from RNA viral
genome to modulate mRNA stability. The data obtained showed that the use of the 3 'UTR
sequence of the encephalomyocarditis virus (EMCV 3'UTR) downstream of the target gene
was not able to significantly modulate the free energy density indicators of the RNA.
However, the sequence influenced the stability of the mRNA (and, therefore, the amount
of protein production) in a cell type and time-dependent manner, indicating a central
role of mRNA-stabilizing binding sites/cellular factors in this process. Our data might
be of interest for the biotechnology community to improve recombinant protein production
in mammalian cell cultures and RNA-based therapy/vaccination approaches.
TREATMENT OF NICOTINE DEPENDENCE IN PATIENTS WITH ONCOLOGICAL DISEASES
Authors: Yablonskiy Petr , Sukhovskaya Olga , Kulikov I.
Published: November 2020

Worldwide, tobacco use is a major behavioral risk factor for cancer. A comparative study conducted in 2017 showed that 7.10 million deaths were associated with smoking. Tobacco consumption not only increases the risk of developing various forms of cancer, but also reduces life expectancy after suffering a cancer, and increases the risk of relapse. In patients with lung cancer who underwent lung resection, smoking increased the risk of nosocomial mortality by three times and significantly increased the incidence of pulmonary complications. In addition to the localization and stage of cancer, abstinence from tobacco consumption has been noted as the strongest predictor of survival in cancer patients. In the United States, National Recommendations for Comprehensive Cancer Treatment (NCCN) included recommendations for the treatment of nicotine addiction, including 12 weeks of behavioral therapy (including telephone counseling) in combination with smoking cessation drugs for all patients receiving treatment in oncological clinics. Treatment of nicotine addiction has proven cost-effective: in particular, it has been shown for a smoking cessation program prior to surgical resection of the lung. Principles 5 A are recommended by the World Health Organization (WHO) to assist in the smoking cessation. There are national guidelines in other countries. In the Russian Federation, clinical guidelines “Tobacco addiction syndrome, tobacco withdrawal syndrome in adults” were adopted. Given the significant impact of smoking on the prognosis of cancer, the treatment of nicotine addiction should be an integral part of the treatment of malignant tumors. The most effective treatment is the combination of pharmacotherapy and cognitive-behavioral therapy. Teaching behavioral methods to overcome the withdrawal syndrome can be conducted by calling the to Quitline, organized by the Ministry of Health of the Russian Federation.
RECTAL NEUROENDOCRINE TUMORS: SHORT-TERM AND LONGTERM RESULTS OF LOCAL EXCISION
Authors: Rybakov Yevgeniy , Khomyakov Yevgeniy , Maynovskaya Olga , Sychev Sergey , Chernyshov Stanislav , Shelygin Yuriy
Published: November 2020

Objective: Rectal neuroendocrine tumors (NETs) are rare neoplasms and, therefore, few clinical observational studies have been performed and few publications are available on this matter. With regard to the aforesaid, it seems topical to analyze and publish results of local rectal NET excisions that were performed at Federal State Budgetary Institution «State Scientific Centre of Coloproctology n.a. A.N. Ryzhikh» of the Ministry of Healthcare of Russia.
Patients and methods: Within the period from December 2011 until June 2018 14 patients, including 4 (28.6%) men and 10 (71.4%) women underwent transanal endoscopic microsurgery (TEM) for rectal NETs at Federal State Budgetary Institution «State Scientific Centre of Coloproctology n.a. A.N. Ryzhikh» of the Ministry of Healthcare of Russia. The mean age of the patients was 53.2 ± 14.14 (24 to 74) years old. Remote results of the treatment performed were traced for all 14 (100%) patients. Kaplan-Meier curves were graphed and then compared using the log-rank (Mantel-Cox) method.
Results: On the basis of findings of pathomorphological studies, 10 (71.4%) patients were diagnosed with stage pT1a tumors, 3 (21.4%) participants had stage pT1b tumors, and 1 (7.2%) patient had stage pT2 tumor; 11 (78.6%) patients enrolled to the study had G1 tumors and 3 (21.4%) participants had G2 tumors; and lymphovascular invasion was detected in 4 (28.5%) of the 14 patients. All excisions were radical (R0). The median follow-up period was 25.5 (9 to 86) months. Disease progression was found in 3 (21.4%) of the 14 patients. NET size exceeding 10 mm was the only statistically significant factor that had impact on relapse-free survival (p=0.032).
Conclusion: Local excision of rectal NETs can be an option of surgical treatment for small (< 10 mm) low-grade tumors. At the same time, precision and safety are of unquestionable priority in TEM.
BIOIMPLANTS — A NEW TREND IN RECONSTRUCTIVE SURGERY
Authors: Kulbakin Denis , Yegorova Dariya , Azovskiy Daniil
Published: November 2020

The review is devoted to the biomaterials and technology of the Plastic and Reconstructive Surgery, which have the main properties: biocompatibility, antibacterial, physical (density, rigidity) and mechanical (sufficient endurance, osteoconductivity, durability) properties. The presented biomaterials and technologies show that modern approaches of tissue engineering are aimed at simulating the extracellular matrix by means of change various forms, components (by adding growth factors, cytokines), which provide the ability to proliferate and differentiate. The introduction of innovative strategies can be a real breakthrough in the future, since there is a socio-economic necessity in the complete treatment and replacement of damaged or non-functional tissues. However, the existing low reproducibility of these methods does not allow judging on long-term outcomes. In particular, we are talking about the interaction of the implant with tissue, although current research show promising results.
DIFFERENTIAL DIAGNOSTICS OF BREAST PATHOLOGY USING CONTRAST ENHANCEMENT PATTERNS IN CONTRAST-ENHANCED SPECTRAL MAMMOGRAPHY
Authors: Ulyanova Roksana , Chernaya A. , Krivorotko Petr , Novikov Sergey , Kanaev Sergey , Artemeva Anna , Shevkunov L. , Tyatkov Stanislav , Danilov Vsevolod
Published: November 2020

Dual-energy contrast-enhanced spectral mammography (CESM) is a new promising method for visualizing pathological changes in breast, which combines digital mammography and a functional assessment of vascularization using intravenous contrast ehnancement. According to accumulated experience CESM is well tolerated by patients and is similar to magnetic resonance imaging with dynamic contrast enhancement (MRI with DCE), but at the same time, CESM is more affordable and can be performed in patients with contraindications for MRI. However, few studies have been conducted to evaluate the role of CESM. In the world literature, interpretation of contrast images is based only on the degree of accumulation of the contrast agent, but we propose a more detailed assessment of the structure of the hypervascular lesions by highlighting the contrast enhancement patterns. Objective: to determine the diagnostic effectiveness of CESM using the contrast enhancement patterns in malignant and benign lesions. Materials and methods. 239 women with suspicious for breast cancer lesions were examined from August 2018 to December 2019. The mean age of the women was 51 years. 322 lesions were revealed, 149 (46.3%) were malignant, 173 (53.7%) were benign. All lesions were histologically confirmed. As a result of the analysis of our data, 9 types of contrast enhancement patterns were distinguished: reticulate, granular, annular, diffuse-spherical, lacunar, cloud-like, heterogeneous-annular, point, cotton-like. Results. Using an additional diagnostic feature - contrast enhancement patterns in lesions, increased the sensitivity of CESM from 91.3% to 98.0% (p=0.26), specificity from 80.3% to 93, 6% (p=0.013), accuracy from 85.4 to 95.7% (p=0.004) in comparison with using of only one feature of contrast enhancement intensity in the differential diagnosis of malignant and benign lesions. Conclusion: thus, this approach of interpreting subtraction images allows to increase the efficiency of CESM in diagnosis of breast cancer.
CHANGES IN THE IMMUNE STATUS OF PATIENTS WITH METASTATIC SOLID TUMORS DURING STEREOTACTIC RADIATION THERAPY
Authors: Zozulya Anton , Novikov Sergey , Baldueva Irina , Girdyuk D. , Yemelyanova Natalya , Tyuryaeva Yelena , Fedosova E. , Antipov F. , Navoloka A. , Kanaev Sergey , Belyaev Aleksey
Published: November 2020

Purpose. To evaluate immunological status in patients with metastatic forms of solid tumors before and at different intervals after stereotactic body radiation therapy (SBRT) of metastatic lesions. Materials and methods. A quantitative assessment and analysis of blood immunological parameters was conducted before irradiation, after 3-4 weeks and 6-8 weeks after SBRT in patients with malignant tumors with oligometastases in the liver and lungs. All peripheral blood samples were analyzed by flow cytometry. Statistical analysis was performed using Friedman and Nemenyi criteria. Results. 3-4 weeks after the end of SBRT, we observed statistically significant increase of T-lymphocytes (CD3+CD19-); T-helpers (CD3+CD4+); activated T-helpers (CD3+CD4+HLA-DR+); activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+) and decrease of B-lymphocytes (CD3-CD19+). Subsequently, after 6-8 weeks after the end of irradiation we detected decrease of T-lymphocytes (CD3+CD19-) and continuing increase in activated T-helpers (CD3+CD4+HLA-DR+) and activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+). Conclusion. Thus, revealed dynamics of immunological parameters indicates the induction of the T-cell link of antitumor immunity against decreasing of indicators of humoral immunity.
CASE OF CYTOMORPHOLOGICAL DIAGNOSIS OF PANCREATIC SCHWANNOMA
Authors: Mikhetko A. , Artemeva Anna , Ivko Olga , Tkachenko Oleg , Grinkevich Marina , Sidorova Aleksandra , Petrik Yuriy , Vasiliev A. , Amelina Inna , Karachun Aleksey , Pelipas Yuriy , Lebedev Konstantin
Published: November 2020

Background: Schwannoma is an extremely rare non-epithelial tumor of the pancreas. Less than 50 cases of pancreatic schwannoma have been described in the literature over the past thirty years and only few cases report has described its findings on Fine-Needle Aspiration (FNA). Preoperative diagnosis of pancreatic schwannoma can be particularly challenging. Pancreatic schwannomas may mimic other, more common pancreatic lesions, such as cystic neoplasms, solid neoplasms, neuroendocrine tumors. Cytomorphological verification of the diagnosis is difficult due to the similarity of Schwannomas with other non-epithelial tumors from spindle cells. Therefore, pancreatic schwannomas have a very high rate of misdiagnosis. Objective: demonstration preoperative diagnosis and treatment of a rare pancreatic tumor. Materials and methods: Here we present a case of preoperative cytomorphological diagnosis of pancreatic schwannoma in a 58-year-old man. During magnetic resonance imaging, computed tomography and endosonography (EUS), the patient was diagnosed the tumor in the head of the pancreas with a diameter of up to 7 cm. For morphological verification of the process, a fine needle aspiration puncture of the formation was performed under EUS control. Diagnosis of pancreatic schwannoma was established by cytomorphological examination of cell block material using immunocytochemical method. Conclusion: the analysis of the result of cytomorphological diagnosis of pancreatic schwannoma is presented.
CERVICAL CANCER AND OTHER HPV ASSOCIATED TUMORS IN RUSSIA
Authors: Zaridze David , Maksimovich Dmitriy , Stilidi Ivan
Published: November 2020

The incidence of cervical cancer in Russia is one of the highest in Europe. At the same time, in European countries, the incidence of other HPV-associated tumors is as low as in Russia. The incidence of cervical cancer is declining in most countries of the world. Unfortunately, in our country, a decrease in the incidence and mortality from cervical cancer before the early 1990s was replaced by an increase in these rates. This trend will continue and reach fairly high numbers in 2030. The increase and subsequent decrease in the incidence and mortality of cervical cancer, which has been observed in developed countries for several decades, is largely the result of population cytological screening with coverage of 70-80% of the female population of the corresponding age. In our country cytological testing organized in the polyclinics, which covered a significant proportion of working women and which, as you know, has been introduced into healthcare practice since 1976, has led only to a temporary decrease in the incidence of cervical cancer. Unfortunately, in the late 1980s, this program ceased to exist and, consequently, a decrease in the incidence of cervical cancer was replaced by its growth. So called dispanserisation, which is presently in place, which includes cytological screening of cervical cancer, has not yet led to the expected results. Despite the fact that the goal of our article is not to evaluate the effectiveness of various screening methods, we consider it necessary to note that screening with HPV testing, which according to randomized trials, is much more effective than cytological examination is widely used in most countries, in combination with HPV vaccination. Prevention of cervical cancer includes: a) mandatory vaccination against HPV in adolescence (11-13 years); b) screening based on HPV testing.
CELL SURFACE MOLECULAR MARKERS FOR IDENTIFICATION OF CANCER STEM CELL POPULATIONS (SYSTEMATIC REVIEW)
Authors: Gluzman Daniil , Filchenkov Aleksey , Ivanovskaya T.
Published: November 2020

The present-day concepts of cancer stem cells (CSC) could be considered as the innovative breakthrough in understanding the nature of cancer that opens new vistas in clinical approach. The review summarizes the available data and the trends in the search of molecular markers that may be advantageous for CSC identification and isolation. The combinations of markers useful for studying CSC phenotype in glioblastoma, neuroblastoma, head and neck squamous cell carcinoma, melanoma, hepatocellular carcinoma, small-cell lung carcinoma, gastric cancer, colorectal cancer, pancreatic cancer, thyroid cancer, breast cancer, cervical cancer, ovarian cancer, renal cell carcinoma, prostate cancer, bladder cancer, and osteosarcoma are reviewed with the emphasis on the genes coding for marker molecules, their chromosomal localization as well as molecular weights of corresponding proteins. The data on the molecular and functional features of 35 CSC markers promising for CSC identification including 26 human CD antigens are briefly analyzed. Furthermore, two cytoplasmic proteins aldehyde dehydrogenase-1 and nestin that may be also recommended for CSC detection are characterized. The involvement of epithelial-to-mesenchymal transition in generation of CSC population is also assessed. The development of targeted therapies for CSC eradication that should be safe for normal stem cells of the corresponding organs and tissues is outlined.
REPORT OF A CASE AND REVIEW OF THE LITERATURE: AXILLARY LYMPH NODES METASTASIS IN PAPILLARY THYROID CANCER PATIENT
Authors: Vabalayte Kristina , Romanchishen Anatoliy , Zaitseva I.
Published: November 2020

Introduction: thyroid cancer (ТС) is the most common endocrine malignancy. Typical and frequent type of TC is papillary carcinoma (PC). Metastases of papillary TC have more often cervical location in II-VI neck lymph nodes groups. Axillary metastasis is not a common finding in the classic type of PC. Adequate Surgery and radioiodine therapy, if necessary, provide the excellent prognosis for most papillary TC patients. Case presentation. 87-year-old woman was presented in our Center with metastatic axillary lymphadenopathy. She had a history of thyroidectomy with central neck dissection 31 years ago for papillary TC. Earlier she underwent right and left lateral neck dissection and 131-I therapy (3 times: after 6 months - 86 mCi, after 12 months- 92 mCi, after 24 months - 98 mCi). On the time of patient presentation in the Center we have found right axillary lymphadenopathy, occipital lymphadenopathy and multiple pulmonary metastases. In our clinic we have performed removal of occipital lymph node metastases and right axillary metastases dissection. Postoperative pathology report has shown infiltration of the cervical and axillary lymph nodes by metastatic papillary TC. After Surgery patient received 131-I therapy one more again (after 3 months - 110 mCi, after 9 months - 150 mCi). Unfortunately, she died after 18 months later. The reason of death was progression of distant metastases at lungs. Follow up period from the initial operation made 32.5 years. Conclusion and discussion. Papillary thyroid cancer patient’s progression free survival is more 10 years. As a rule a papillary TC patients has survived for many years after the initial surgery. Exclusively rarely TC metastases can emerge in different atypical places and in the axillary lymph nodes also (more than 31 years after initial Surgery) that maybe associated with a poor prognosis. Case report is unique, because there are 16 equal clinical cases in world literature.
Šiuolaikinės idiopatinės plaučių fibrozės gydymo galimybės
Authors: Blažytė Laima , Malakauskas Kęstutis
Published: November 2020

Idiopatinė plaučių fibrozė - tai specifinė lėtinės neaiškios kilmės progresuojančios fibrozinės idiopatinės intersticinės pneumonijos forma. Ši liga pasireiškia suaugusiesiems ir pažeidžia tik plaučius. Idiopatinė plaučių fibrozė charakterizuojama progresuojančiu dusuliu, prastėjančia plaučių funkcija ir siejama su bloga prognoze. Sergant idiopatine plaučių fibroze, nustatomi įprastinės intersticinės pneumonijos radiologiniai ir (arba) histologiniai požymiai [1].
Obstrukcinė miego apnėja ir arterinė hipertenzija
Authors: Pilkauskaitė Guoda , Verseckaitė Raimonda
Published: November 2020

Straipsnyje aptariamas obstrukcinės miego apnėjos ir arterinės hipertenzijos ryšys, šiandieninės diagnostikos ir gydymo ypatybės.
Plaučių policistozė
Authors: Kalinauskaitė-Žukauskė Virginija
Published: November 2020

Plaučių policistozė - vienas dažniausių plaučių sklaidos sutrikimų. Paprastai ši sklaidos yda diagnozuojama naujagimystės arba kūdikystės laikotarpiu, o suaugusiesiems labai retai. Todėl suaugusiųjų gydytojai rečiau susiduria su šia patologija ir ja sergančių pacientų priežiūra. Straipsnyje pateikiami esminiai plaučių policistozės diagnostikos, gydymo ir priežiūros aspektai (tiek vaikams, tiek suaugusiesiems).
Genetiškai modifikuoti organizmai ir sintetinė biologija
Authors: Serapinas Danielius
Published: November 2020

Genų inžinerija ir genetiškai modifikuoti organizmai (GMO) - gan seni reiškiniai, bet vis dar labai prieštaringai vertinami. Tai, kad pasaulis neapsisprendęs ir neturi bendros nuomonės dėl GMO, gerausiai atspinti Jungtinių Amerikos Valstijų (JAV) ir Europos sąjungos (ES) pozicijos: jos įgyvendina visiškai skirtingą GMO politiką ir teisinį reguliavimą. JAV akcentuoja teigiamus biotechnologijų pažangos aspektus ir vykdo švelnią GMO politiką, o ES pabrėžia GMO plėtros keliamą riziką ir įgyvendina griežtą reguliavimą GMO atžvilgiu.
Omalizumabo efektyvumas gydant sunkią astmą: klinikinis atvejis
Authors: Tamašauskienė Laura , Barkauskienė Diana , Šitkauskienė Brigita
Published: November 2020

Omalizumabas - monokloninis antikūnas prieš imunoglobuliną E, skiriamas sunkia progresuojančia alergine astma sergantiems pacientams, kuriems simptomai dažnai kartojasi dieną arba pažadina naktį, kuriems buvo daug dokumentuotų sunkių astmos paūmėjimų, nepaisant kasdien vartojamų didelių inhaliuojamųjų gliukokortikoidų ir ilgai veikiančių beta 2 agonistų dozių. Omalizumabas pagerina astmos kontrolę, sumažina šios ligos paūmėjimų skaičių ir gliukokortikoidų poreikį. Mokslininiai tyrimai rodo, kad šis vaistas efektyvus gydant lėtine idiopatine dilgėline sergančius asmenis, kurių reakcija į gydymą H1 antihistamininiais preparatais yra nepakankama. Straipsnio tikslas - apžvelgti omalizumabo efektyvumą gydant sunkią astmą bei pristatyti klinikinį atvejį.
Symbicort SMART – galimybė geriau kontroliuoti astmos simptomus
Authors: Kaletkienė Aušra
Published: November 2020

Astmos kontrolė klinikinėje praktikoje nėra optimali nepaisant didelio vaistų pasirinkimo. Nepakankama astmos kontrolė susijusi su padidėjusia paūmėjimų rizika, prastesne gyvenimo kokybe, didesnėmis gydymo išlaidomis ir sumažėjusiu darbo našumu [2]. Kadangi astma yra viena dažniausių lėtinių ligų pasaulyje [2], akivaizdu, kaip svarbu kuo efektyviau ją gydyti. Pagal GINA (angl. Global Initia-tive for Asthma, liet. Visuotinė astmos iniciatyva) astmos gydymas turi būti grindžiamas paciento astmos kontrolės lygmeniu, kuris nustatomas pagal dienos metu juntamus simptomus, įprastos veiklos ribotumą, prabudimus naktį dėl ligos ir simptominių – greitai veikiančių bronchus plečiančių – vaistų vartojimo dažnį. Daugelis pacientų linkę pervertinti simptomų kontrolę ir tinkamai neįvertinti būklės sunkumo, teigdami, kad jie puikiai toleruoja simptomus ir kasdienės veiklos apribojimus. Tai parodė ir atliktas tyrimas, kurio metu didžiausias dėmesys telktas į astmos kontrolės vertinimą pagal astmos kontrolės klausimyną [3]. Tyrime dalyvavo 1363 stabilios eigos astma sergančių pacientų (vidutinis amžius 38 ± 14 metų, 60,3 proc. moterų; 69,1 proc. nerūkantieji). Pacientų astmos kontrolė pagal GINA apibrėžtą astmos kontrolės klasifikaciją, buvo: astma kontroliuojama 13,6 proc., iš dalies kontroliuojama 34,2 proc., nekontroliuojama 52,3 proc. Nors dauguma pacientų ir gydytojų suvokė ligą kaip kontroliuojamą arba iš dalies kontroliuojamą, tarp grupių atitikimas buvo išties mažas (κ = 0,53) (1 pav.). Taigi tikėtina, kad ligoniai gydytojui gali pateikti klaidingą informaciją apie astmos kontrolę (subjektyvumo įtaka) ir gauti netinkamą gydymą. Su nepakankama astmos kontrole susiję veiksniai yra gydymo režimo nesilaikymas ir bloga inhaliavimo technika [4, 5, 6]. Norint sukurti veiksmingą astmos gydymo būdą ir pagerinti ligonių gydymo rezultatus, svarbu suvokti skirtingą pacientų požiūrį į savo būklę bei pritaikyti gydymą, atitinkantį jų specifinius poreikius. Tam būtinas puikus gydytojo ir paciento bendradarbiavimas. Labai svarbią vietą užima pacientų inhaliavimo technikos mokymas.
Adaptación a la Nueva Realidad Sociocultural en España: Propuestas para la Mejora de la Asistencia en Traducción e Interpretación Jurídica en los Servicios Públicos
Authors: Arcos Álvarez Leticia
Published: November 2020

Resumen: En los últimos tiempos, el panorama legal de España ha cambiado a base de enmiendas, nuevos proyectos de leyes, reglamentos, etc., lo que, sumado a un período de grandes modificaciones sociales en materia de trabajo, política, economía y migraciones, ha dado lugar a una nueva realidad que afecta a todo el conjunto de ciudadanos, y en especial, a la población extranjera no hispanohablante que reside en nuestro país. Hoy en día, vivimos en una sociedad multilingüe y multicultural en la que las comunidades de inmigrantes tienen que hacer frente a grandes diferencias durante su vida cotidiana, principalmente relacionadas con las barreras lingüísticas y culturales. El proceso de integración y de aprendizaje del idioma es lento y se puede prolongar durante bastante tiempo, período durante el cual estas personas tienen que realizar trámites burocráticos sin poseer los conocimientos lingüísticos y del sistema administrativo adecuados. Cuando estos obstáculos impiden la comunicación es necesario desarrollar soluciones que permitan el entendimiento entre las partes. En este punto aparece la figura del intérprete o mediador intercultural, que interviene para garantizar una comunicación efectiva.Abstract: In recent times, Spain's legal scenario has changed with amendments, new bills, regulations, etc. This new picture, along with a period of major social changes in labor, politics, economy and migrations has given rise to a new reality that affects the whole group of citizens, and especially the non-Spanish-speaking foreign population living in our country. Nowadays, we live in a multilingual and multicultural society in which immigrant communities have to cope with major differences during their daily lives, mainly related to linguistic and cultural barriers. The process of integration and language learning is slow and can be prolonged for a long time, during which these people have to perform bureaucratic procedures without adequate linguistic and administrative knowledge. When these obstacles hinder communication it is necessary to develop solutions allowing the understanding between the parties. The role of the intercultural interpreter or mediator then appears, who intervenes to guarantee an effective communication.
THE HISTORY OF THE PROGRESS OF DISTANCE LEARNING AND MODERN METHODS OF TEACHING RUSSIAN AS A FOREIGN LANGUAGE
Authors: Ивкина М.И. , Хамраева Е.А.
Published: November 2020

В статье рассматриваются возможности дистанционного обучения в современной реальности – посредством глобальной сети Интернет и популярных онлайн-сервисов виртуального общения. Многие университеты и школы имеют сегодня серьезный опыт не только локального, но и дистанционного обучения. Это могут быть как кратковременные курсы, так и получение основного образования. Главное достоинство дистанционного обучения заключается в гибкости, мобильности и разнообразии формируемых компетенций. В статье представлены функциональные возможности использования платформ при обучении иностранцев русскому языку на примере образовательного аккаунта @ru_lang_club в социальной сети Instagram.

Distance education today has great prospects. Many universities and schools have strong experience not only of local, but also of distance learning. It can be both short-term courses and basic education. The article discusses the possibilities of distance learning in modern reality, through the global Internet and the popular online virtual communication services. The main advantage of the new distance learning format is the innovativeness and mobility of acquiring skills and knowledge. The functionality of using the platforms for teaching foreigners the Russian language is shown on the example of the educational account @ru_lang_club on the social network Instagram.
PHRASE THEORY: AN UPDATED TRADITION
(a phrase in the aspect of psycholinguistic experimtnt)
Authors: Милованова М.С.
Published: November 2020

Монография К.Я. Сигала посвящена постижению и осмыслению словосочетания как единицы языка и речи – как реальной лингвистической и психолингвистической единицы. Автор в деталях реконструирует «проблему словосочетания», его внимание привлекают традиционно дискуссионные вопросы и моменты новые, которые не были предметом специального рассмотрения. Принципиальная новизна исследования заключается в применении методик психолингвистического эксперимента для ответа на вопрос о природе, генезисе и прагматике словосочетания.

Monograph by K.Ya. Sigal is devoted to comprehension and understanding of a phrase as a unit of language and speech – as a real linguistic and psycholinguistic unit. The author reconstructs in detail the «problem of phrase», his attention is attracted by traditionally debatable issues and new points that were not the subject of special consideration. The principal novelty of the research is the use of psycholinguistic experiment techniques to answer the question about the nature, genesis and pragmatic of the phrase.
Pengaruh Keputusan Pendanaan, Keputusan Investasi, Kebijakan Dividen, Dan Arus Kas Bebas Terhadap Nilai Perusahaan
Authors: Fadly Bahrun Muhammad , Tifah Tifah , Firmansyah Amrie
Published: November 2020

This study examines the effect of funding decisions, investment decisions, dividend policies, and free cash flow on firm value. The samples used in this study are consumer goods industry companies listed on the Indonesia Stock Exchange (IDX) during 2016-2019. Based on purposive sampling, the selected sample is 34 companies, so that the total sample is 136 observations. Hypothesis testing is carried out using multiple linear regression analysis of panel data. The test results show that funding decisions positively affect firm value, while investment decisions do not affect firm value. This study also shows that dividend policy and free cash flow have a negative effect on firm value.
ETHICAL ISSUES IN MARKETING: WITH SPECIAL REFERENCE
TO LIBRARY RESOURCE AND SERVICES
Authors: Vyas Priyanki , Parmar Kinjal
Published: November 2020

This paper deal with the ethical issues in marketing of library resources and services. With the increasing demand of users library need to promote and market their resource to aware users from library resources and services. Marketing is process of managing profitable relation with customer in ethical manner. Digital era wants to more and more marketing for the wide spread of information in market. Librarian need to follow the ethical behaviour and use the legal tools to promote the resource, service and information of the library. Market of library resource and services impact the usage of library, to increase the library usage library start unethical marketing of product and services. Ethical librarianship promotes the library resources for value added service, avoid ethical issues, and increase the usage of library resources and services through the ethical marketing of resource and services.
Magnetic Pulse Welding Technology
Authors: Jassim Ahmad
Published: November 2020

In this paper, the benefits of using Magnetic Pulse machine which is belong to Non-conventional machine instead of conventional machine. Magnetic Pulse Technology is used for joining dissimilar metals, and for forming and cutting metals. It is a non contact technique. Magnetic field is used to generate impact magnetic pressure for welding and forming the work piece by converted the electrical energy to mechanical energy. It is enable us to design previously not possible by welding dissimilar materials and allowing to welds light and stronger materials together. It can be used to weld metallic with non metallic materials to created mechanical lock on ceramics, polymers, rubbers and composites. It is green process; there is no heat, no radiation, no gas, no smoke and sparks, therefore the emissions are negligible.
Estimation of the Consumer Peak Load for the Iraqi Distr ibution System Using intelligent Methods
Authors: Al-Nama M. A. , Al-Hafid M. S. , Al-Fahadi A. S.
Published: November 2020

The drastic increase of residential load consumption in recent years result in over loading feeder lines and transformers for the Iraqi northern area distribution system especially in the city of Mosul. Solution for this problem require up to date research consumers load study to find the proper solution to stop excess overload in the transformers and the feeders. This paper include the regional survey for samples of consumers representing typical types of different standard of living and energy consumption by distributing questioners contain list of information such as load type in daily use. Also current readings are recorded for the individual consumer for the months of the year 2006. In addition to those readings, energy consumption is recorded once every two months. The registered readings are used in conjunction with the list of questionnaires to find a sample (for different loads) that coincide with the list of questionnaires for current and energy readings. Resulting in the feasibility of using the sample to know the peak value of current for any consumer even if he is not included in the list of questionnaires and for any new consumer, since it become possible to decide the size of the transformers and feeder lines, to overcome the problem of overloading in any part of the distribution system. The Artificial Neural Network (ANN) is used in this paper to find the above mentioned sample.
„Wer die Welt nicht kennet, der kennet auch sich und GOtt nicht.“
Authors: Lohsträter Kai
Published: November 2020

Theologische oder religionsgeschichtliche Aspekte spielen im Fortschrittsnarrativ, in dem die Entwicklung der politischen Zeitungen in der Frühen Neuzeit gewöhnlich erzählt wird,
bisher keine größere Rolle. Vor diesem Hintergrund verfolgen die Ausführungen die Absicht, ins Bewusstsein zu rufen, dass die Nachrichtenblätter nicht ausschließlich als
profanliterarisches Medium betrachtet werden sollten. Am Beispiel des protestantischen, insbesondere pietistischen Umfelds zeigt der Beitrag, welche zeitgenössischen Vorstellungen
von Zeitungen und des Umgangs mit ihnen im ausgehenden 17. und 18. Jahrhundert kursierten und welche Spuren religiösen Denkens in der Berichterstattung über die Welthändel in den
Blättern zu finden sind.
Theoretical analyses of criminal cases initiated due to offences of illegal use of human body
Authors: Andrea Tünde Barabás , Szabó Judit
Published: November 2020

Although occasionally there are talks and rumours about disappearances or kidnappings in Hungary for the purpose of organ and tissue trading or trafficking, there have not yet been confirmed cases from authentic sources of such offences in respect of the country. Every so often we hear of the ever-increasing international organ trading or trafficking. The National Institute of Criminology conducted a research project in 2017-2018 with the title Theoretical analyses of criminal matters initiated due to offences of illegal use of human body. The purpose of the research was to explore and analyse the characteristic features of criminal proceedings initiated in cases of illegal use of human body, and of the underlying offences. In addition, we also aimed at identifying potential enforcement difficulties of the factual situations, as well as mapping other anomalies, and assessing the domestic status of the issue. Accordingly, the subject of our research project focused on the legislative framework of the offence of illegal use of human body, its major domestic and international aspects, the characteristics of the criminal proceedings initiated due to such offences, and the experiences of enforcement. According to the findings of our research, it is only unambiguous, consistent and seamless professional legislation together with leveraging appropriate professional knowledge that can grant real protection in the field of the procedures and interventions affected by the offence of the illegal use of human body. Even though the situation in Hungary does not seem to be worrying, some anomalies of the legislative framework are obvious in light of our findings. The below paper concludes and sums up the most important findings of the research project.
The Evolution and Communicational Aspects of Mediation
Authors: Németh Viktor
Published: November 2020

Since mediation, as a form of alternative dispute resolution, has become part of the canonized legal system, it has come to life and has made its own path of development from the 1950s to the present. In this paper, the process and the stages of it are discussed from communicational point of view through the terminology of the PTC. The sections also represent the types of mediation. Relationships and interactions between the types are also the subject of this study, as well as the scopes for certain types. The participatory theory of communication (PTC) allows us to review the development of mediation in the 20th and 21st centuries, from a facilitative mediation to a transformative mediation, according to a unified, transparent framework.
Kepler Binary Stars in the NGC 6819 Open Cluster: KIC 5113146 and KIC 5111815
Authors: Soydugan Esin , Aliçavuş Fahri , Soydugan Faruk , Bilir Selçuk
Published: November 2020

In this study, an investigation of two double-lined binary stars KIC 5113146 and KIC 5111815 in the NGC 6819 open cluster is presented based on both photometric and spectroscopic data. Simultaneous analysis of light and radial velocity curves was made and the absolute parameters of the systems’ components were determined for the first time. We find that both systems have F-type main-sequence components. The masses and radii were found to be M

1
 = 1.29 ± 0.02M
⊙, R

1
 = 1.47 ± 0.03

and M

2
 = 1.19 ± 0.02

, R

2
 = 1.13 ± 0.02

for the primary and secondary components of KIC 5113146; and M

1
 = 1.51 ± 0.08

, R

1
 = 2.02 ± 0.05

and M

2
 = 1.19 ± 0.07

, R

2
 = 1.32 ± 0.04

for the components of KIC 5111815, respectively. The evolutionary status of the components was evaluated based on the MESA evolutionary tracks and isochrones. The ages of KIC 5111815 and KIC 5113146 were derived to be about 2.50 ± 0.35 Gyr and 1.95 ± 0.40 Gyr, respectively. Photometric distances were calculated to be 2850 ± 185 pc for KIC 5113146 and 3120 ± 260 pc for KIC 5111815. The results reveal that both KIC 5113146 and KIC 5111815 systems are the most likely members of NGC 6819.