bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine Learning Reveals Protein Signatures in CSF and Plasma Fluids of Clinical Value for ALS
Authors: Bereman Michael S. , Beri Joshua , Enders Jeffrey R. , Nash Tara
Published: October 2018

We use shotgun proteomics to identify biomarkers of diagnostic and prognostic value in individuals diagnosed with amyotrophic lateral sclerosis. Matched cerebrospinal and plasma fluids were subjected to abundant protein depletion and analyzed by nano-flow liquid chromatography high resolution tandem mass spectrometry. Label free quantitation was used to identify differential proteins between individuals with ALS (n = 33) and healthy controls (n = 30) in both fluids. In CSF, 118 (p-value < 0.05) and 27 proteins (q-value < 0.05) were identified as significantly altered between ALS and controls. In plasma, 20 (p-value < 0.05) and 0 (q-value < 0.05) proteins were identified as significantly altered between ALS and controls. Proteins involved in complement activation, acute phase response and retinoid signaling pathways were significantly enriched in the CSF from ALS patients. Subsequently various machine learning methods were evaluated for disease classification using a repeated Monte Carlo cross-validation approach. A linear discriminant analysis model achieved a median area under the receiver operating characteristic curve of 0.94 with an interquartile range of 0.88–1.0. Three proteins composed a prognostic model (p = 5e-4) that explained 49% of the variation in the ALS-FRS scores. Finally we investigated the specificity of two promising proteins from our discovery data set, chitinase-3 like 1 protein and alpha-1-antichymotrypsin, using targeted proteomics in a separate set of CSF samples derived from individuals diagnosed with ALS (n = 11) and other neurological diseases (n = 15). These results demonstrate the potential of a panel of targeted proteins for objective measurements of clinical value in ALS.
Generation of Bose-Einstein Condensates’ Ground State Through Machine Learning
Authors: Liang Xiao , Zhang Huan , Liu Sheng , Li Yan , Zhang Yong-Sheng
Published: October 2018

We show that both single-component and two-component Bose-Einstein condensates’ (BECs) ground states can be simulated by a deep convolutional neural network. We trained the neural network via inputting the parameters in the dimensionless Gross-Pitaevskii equation (GPE) and outputting the ground-state wave function. After the training, the neural network generates ground-state wave functions with high precision. We benchmark the neural network for either inputting different coupling strength in the GPE or inputting an arbitrary potential under the infinite double walls trapping potential, and it is found that the ground state wave function generated by the neural network gives the relative chemical potential error magnitude below 10−3. Furthermore, the neural network trained with random potentials shows prediction ability on other types of potentials. Therefore, the BEC ground states, which are continuous wave functions, can be represented by deep convolutional neural networks.
Urothelium proliferation is a trigger for renal crystal deposits in a murine lithogenesis model
Authors: Bilbault Héloïse , Perez Joëlle , Huguet Léa , Vandermeersch Sophie , Placier Sandrine , Tabibzadeh Nahid , Frochot Vincent , Letavernier Emmanuel , Bazin Dominique , Daudon Michel , Haymann Jean-Philippe
Published: October 2018

Most mouse kidney stone models induce nephrocalcinosis rather than urolithiasis. The aim of our study was to find an accelerated experimental model in order to study the early events of stone formation, that is, at the time of crystal binding to intrarenal urothelium. C57B6 mice exposed to vitamin D supplements and water containing hydroxyl-L-proline, ammonium chloride and calcium chloride were studied for 42 days. A group receiving urothelial cell mitogen Fibroblast Growth Factor 7 (FGF7) was compared to control group receiving saline. Calcium oxalate monohydrate (COM) crystals were detected in urines by day 2 and within urinary spaces in specialized fornix areas in both groups as soon as day 14 with enhanced deposits in FGF7 group compared to controls at day 21. Urothelial cells proliferation, uroplakin III downregulation and de novo expression of osteopontin receptor CD44 detected in FGF7 group, were delayed in the control group (day 42). Crystal aggregates within specialized fornix areas by day 42 were located in urinary spaces but also within and under a multilayered metaplastic urothelium, simultaneous to macrophages influx. Point of note, administration of a normal diet by day 21 was responsible for a spontaneous crystal clearance. Our data show that under supersaturation conditions, urothelial cell proliferation and calcium oxalate crystal retention occur within specialized fornix areas. Enhanced crystal deposits following FGF7 administration suggest that urothelium proliferation would be a relevant trigger for renal stone formation.
Relationship between cardiovascular health metrics and physical performance in community-living people: Results from the Longevity check-up (Lookup) 7+ project
Authors: Landi Francesco , Calvani Riccardo , Picca Anna , Tosato Matteo , D’Angelo Emanuela , Martone Anna Maria , Serafini Elisabetta , Ortolani Elena , Savera Giulia , Salini Sara , Acampora Nicola , Bernabei Roberto , Marzetti Emanuele
Published: October 2018

Cardiovascular health metrics (CHMs) may predict disability independent of vascular events. Though, the link between CHMs and physical performance is unclear. This relationship was explored using data from the Longevity check-up (Lookup) 7+ project. Lookup 7+ is an ongoing cross-sectional survey conducted in unconventional settings across Italy. People who are at least 18-year-old and provide written informed consent are eligible. CHMs [i.e., smoking status, healthy diet, body mass index (BMI), blood pressure, blood cholesterol, and diabetes status] are assessed through closed questions and objective measurements. Physical performance is measured via the 5-repetition chair-stand test. Analyses included 7446 participants (55.5 ± 14.9 years; 56% women). Physical performance positively correlated with CHMs scores, such that participants who scored higher (6–7 points) completed the chair-stand test about 2 s faster than those scoring lower (1–2 points). In fully adjusted analysis, better physical performance was more frequently observed in younger, non-smoking, physically active men, with ideal BMI, and no diabetes. Our findings indicate a gradient of better physical function with increasing CHMs scores. Future investigations should establish the longitudinal effect of unhealthy behaviours and cardiovascular risk factors on physical performance and verify whether implementation of large-scale primordial cardiovascular prevention may positively impact physical fitness.
Atomic imprinting into metallic glasses
Authors: Li Rui , Chen Zheng , Datye Amit , Simon Georg H. , Ketkaew Jittisa , Kinser Emily , Liu Ze , Zhou Chao , Dagdeviren Omur E. , Sohn Sungwoo , Singer Jonathan P. , Osuji Chinedum O. , Schroers Jan , Schwarz Udo D.
Published: October 2018

Nanoimprinting by thermoplastic forming has attracted significant attention due to its promise of low-cost fabrication of functionalized surfaces and nanostructured devices, and metallic glasses have been identified as a material class ideally suited for nanoimprinting. In particular, their featureless atomic structure suggests that there may not be an intrinsic size limit to the material’s ability to replicate a mould. Here we demonstrate atomic-scale imprinting into a platinum-based metallic glass alloy under ambient conditions using atomic step edges of a strontium titanate single crystal as a mould. The moulded metallic glass replicates the ‘atomic smoothness’ of the strontium titanate, with identical roughness to the one measured on the mould even after multiple usages and with replicas exhibiting an exceptional long-term stability of years. By providing a practical, reusable, and potentially high-throughput approach for atomic imprinting, our findings may open novel applications in surface functionalization through topographical structuring.
Global distribution data for cattle, buffaloes, horses, sheep, goats, pigs, chickens and ducks in 2010
Authors: Gilbert Marius , Nicolas Gaëlle , Cinardi Giusepina , Van Boeckel Thomas P. , Vanwambeke Sophie O. , Wint G. R. William , Robinson Timothy P.
Published: October 2018

Global data sets on the geographic distribution of livestock are essential for diverse applications in agricultural socio-economics, food security, environmental impact assessment and epidemiology. We present a new version of the Gridded Livestock of the World (GLW 3) database, reflecting the most recently compiled and harmonized subnational livestock distribution data for 2010. GLW 3 provides global population densities of cattle, buffaloes, horses, sheep, goats, pigs, chickens and ducks in each land pixel at a spatial resolution of 0.083333 decimal degrees (approximately 10 km at the equator). They are accompanied by detailed metadata on the year, spatial resolution and source of the input census data. Two versions of each species distribution are produced. In the first version, livestock numbers are disaggregated within census polygons according to weights established by statistical models using high resolution spatial covariates (dasymetric weighting). In the second version, animal numbers are distributed homogeneously with equal densities within their census polygons (areal weighting) to provide spatial data layers free of any assumptions linking them to other spatial variables.
Embedding Methods in Materials Discovery
Authors: Sushko Peter V. , Huang Chen , Govind Niranjan , Kowalski Karol
Published: October 2018

This chapter reviews a class of methods that allow for high accuracy and lift the constraints imposed by the periodic boundary conditions. Known under the generic name of the embedded cluster approach, this group of methods stems from the molecular perspective on matter, i.e., all materials are finite and can be represented using a finite collections of atoms, subjected to the boundary conditions that reproduce the rest of the system that is not necessarily periodic. We then give a few examples of using these methods in materials modeling and offer an outlook for the future.
Computational Design of Photovoltaic Materials
Authors: Butler Keith T. , Davies Daniel W. , Walsh Aron
Published: October 2018

Design principles are outlined for developing new materials that enable sustainable solar energy conversion through light-to-electricity conversion in photovoltaic devices. Important physical descriptors that are accessible from first-principles simulations include optical absorption, electrical conductivity, work-functions, thermodynamic stability, and defect tolerance.
Rapid assembly of cyclopentene spiroisoindolinones via a rhodium-catalysed redox-neutral cascade reaction
Authors: Yuan Tingting , Pi Chao , You Chang , Cui Xiuling , Du Sidong , Wan Ting , Wu Yangjie
Published: October 2018

A rhodium-catalysed redox-neutral cascade reaction starting from benzamides and cyclopropenones for the rapid assembly of cyclopentene spiroisoindolinones has been developed.
Light-enhanced hypoxia-responsive nanoparticles for deep tumor penetration and combined chemo-photodynamic therapy
Authors: Li Zhongbao , Wu Min , Bai Hongzhen , Liu Xingang , Tang Guping
Published: October 2018

Herein, we report a light-enhanced hypoxia-responsive nanoparticle for synergic treatment of solid tumors.
Molecular simulations reveal that a short helical loop regulates thermal stability of type I cohesin–dockerin complexes
Authors: Gunnoo Melissabye , Cazade Pierre-André , Bayer Edward A. , Thompson Damien
Published: October 2018

Re-engineering linker regions to boost the thermal stability of protein–protein complexes.
Unraveling the highest oxidation states of actinides in solid-state compounds with a particular focus on plutonium
Authors: Ao Bingyun , Lu Haiyan , Yang Zhenfei , Qiu Ruizhi , Hu Shu-Xian
Published: October 2018

The nature and extent of the highest oxidation states (HOSs) in solid-state actinide compounds are still unexplored compared with those of small molecules, and there is burgeoning interest in studying the actinide–ligand bonding nature in the condensed state.
Dendritic silica@aqueous miscible organic-layered double hydroxide hybrids
Authors: Suo Hongri , Chen Chunping , Buffet Jean-Charles , O'Hare Dermot
Published: October 2018

We present the synthesis of a series of dendritic hierarchical hybrid SiO2@AMO-LDHs with tuneable properties suitable for a wide range of applications.
Silicon nanoparticles: characterization and toxicity studies
Authors: Kustov Leonid M. , Mashkin Peter V. , Zakharov Valery N. , Abramenko Natalia B. , Krysanov Evgeniy Y. , Aslanov Leonid A. , Peijnenburg W.
Published: October 2018

This paper is devoted to characterization and toxicity testing of an emerging class of nanomaterials for diverse applications: silicon nanoparticles.
Generation of hot electrons in nanostructures incorporating conventional and unconventional plasmonic materials
Authors: Liu Tianji , Besteiro Lucas V. , Wang Zhiming , Govorov Alexander O.
Published: October 2018

The choice of materials for hot electron generation and injection: peak efficiency or broadband.
Olive leaf extract counteracts cell proliferation and cyst growth in anin vitromodel of autosomal dominant polycystic kidney disease
Authors: Toteda G. , Vizza D. , Lupinacci S. , Perri A. , Scalise M. F. , Indiveri C. , Puoci F. , Parisi O. I. , Lofaro D. , La Russa A. , Gigliotti P. , Leone F. , Pochini L. , Bonofiglio R.
Published: October 2018

–Autosomal dominant polycystic kidney disease (ADPKD) is characterized by progressive enlargement of kidney cysts, leading to chronic kidney disease.
Transcriptomics in pain research: insights from new and old technologies
Authors: Starobova H. , S. W. A. Himaya , Lewis R. J. , Vetter I.
Published: October 2018

Physiological and pathological pain involves a complex interplay of multiple cell types and signaling pathways.
Deconvolution of dopant-derived extrinsic and intrinsic effects in TiO2 nanoparticulate thin films
Authors: Ren Hangjuan , Wang Jieyu , Ma Hongyang , Cao Fuyang , Jiang Yue , Koshy Pramod , Sorrell Charles Christopher
Published: October 2018

The role and mechanism of doping in the extrinsic and intrinsic effects on photocatalysts.
A two-photon fluorescent probe for detecting lipid droplet viscosity in living cells and zebra fish
Authors: Peng Min , Yin Junling , Lin Weiying
Published: October 2018

A fluorescent probe CBA with high photostability to measure the viscosity changes of lipid drops.
Nickel-catalyzed regioselective arylation of aromatic amides with aryl iodides enabled by an N,O-bidentate directing group
Authors: Li Pinhua , Wang Guan-Wu , Chen Hao , Wang Lei
Published: October 2018

A bidentate directing group enabled ortho-arylation of C(sp2)–H bonds in aromatic carboxamides with aryl iodides under nickel-catalysis was developed.
Efficient ethylene copolymerization with polar monomers using palladium anilinonaphthoquinone catalysts
Authors: Ding Lin , Cheng Hailong , Li Yanqing , Tanaka Ryo , Shiono Takeshi , Cai Zhengguo
Published: October 2018

Copolymerizations of ethylene with methyl acrylate (MA) and 5-norbornen-2-yl acetate (NBAC) were explored using anilinonaphthoquinone-ligated palladium catalysts.
The first morphologically controlled synthesis of a nanocomposite of graphene oxide with cobalt tin oxide nanoparticles
Authors: Jamil Saba , Ahmad Hasnaat , Shafiq-ur-Rehman Shafiq-ur-Rehman , Khan Shanza Rauf , Saeed Ashraf Janjua Muhammad Ramzan
Published: October 2018

Tin cobalt hydroxide nanoparticles were synthesized by a simple hydrothermal technique. A graphene based cobalt tin oxide nanocomposite was synthesized by a solvothermal method.
Preparation of high-concentration substitutional carbon-doped TiO2 film via a two-step method for high-performance photocatalysis
Authors: Wu Jun , Jiang Xudong , Zhang Yupeng , Fu Qiang , Pan Chunxu
Published: October 2018

In this paper, we present a facile two-step method for preparing a high-concentration substitutional carbon-doped TiO2 (TiO2−xCx) film.
In situ and controllable synthesis of Ag NPs in tannic acid-based hyperbranched waterborne polyurethanes to prepare antibacterial polyurethanes/Ag NPs composites
Authors: Luo Shun , Fan Lin , Yang Kai , Zhong Zhen , Wu Xiaojian , Ren Tianbin
Published: October 2018

A simple and facile method was developed for preparation of antibacterial polyurethanes/Ag NPs composites by using tannic acid-based hyperbranched waterborne polyurethanes (THWPU).
NOxreduction by CO over ASC catalysts in a simulated rotary reactor: effect of CO2, H2O and SO2
Authors: Sun Peiliang , Cheng Xingxing , Lai Yanhua , Wang Zhiqiang , Ma Chunyuan , Chang Jingcai
Published: October 2018

The influence of CO2, H2O and SO2on the NO reduction by CO over Fe/Co activated semi-coke catalyst was investigated in a simulated rotary reactor.
Intense pulsed light (IPL) annealed sol–gel derived ZnO electron injector for the production of high efficiency inverted quantum dot light emitting devices (QLEDs)
Authors: Kathirgamanathan Poopathy , Kumaraverl Muttulingam , Vanga Raghava Reddy , Ravichandran Seenivasagam
Published: October 2018

Room temperature intense pulsed light annealing (photonic annealing, pulsed forge) renders the sol–gel derived ZnO films highly conductive and hydrophobic with improved interface with the colloidal quantum dots.
Homogeneous visible light-driven hydrogen evolution by the molecular molybdenum sulfide model [Mo2S12]2−
Authors: Rajagopal Ashwene , Venter Felix , Jacob Timo , Petermann Lydia , Rau Sven , Tschierlei Stefanie , Streb Carsten
Published: October 2018

The first example of light driven, homogeneous hydrogen evolution reactivity by the smallest thiomolybdate cluster [Mo2S12]2− is reported together with initial insights into the catalytic and deactivation mechanism.
Capillary imbibition in a square tube
Authors: Yu Tian , Zhou Jiajia , Doi Masao
Published: October 2018

The dynamics of liquid imbibition in the bulk and fingers are analyzed accounting for the coupling of the two parts.
Distinct relaxation timescales of neurites revealed by rate-dependent indentation, relaxation and micro-rheology tests
Authors: Gong Ze , Fang Chao , You Ran , Shao Xueying , Wei Xi , Chang Raymond Chuen-Chung , Lin Yuan
Published: October 2018

Although the dynamic response of neurites is believed to play crucial roles in processes like axon outgrowth and formation of the neural network, the dynamic mechanical properties of such protrusions remain poorly understood.
Capillary force induced air film for self-aligned short channel: pushing the limits of inkjet printing
Authors: Tao Ruiqiang , Fang Zhiqiang , Zhang Jianhua , Ning Honglong , Chen Jianqiu , Yang Caigui , Zhou Yicong , Yao Rihui , Song Yongsheng , Peng Junbiao
Published: October 2018

Channel self-aligning on unmodified substrate exists in printing, as the inducing of air film by the coffee ring effect.
Effects of transplantation of FGF-2-transfected MSCs and XACB on TNF-α expression with avascular necrosis of the femoral head in rabbits
Authors: Peng Wuxun , Dong Wentao , Zhang Fei , Wang Jianbo , Zhang Jian , Wu Jianhua , Wang Lei , Ye Chuan , Li Qing , Deng Jin
Published: October 2018

Objective: The present study aimed to investigate the effect of the transplantation of basic fibroblast growth factor (FGF-2) gene-transfected mesenchymal stem cells (MSCs) and xenogeneic antigen-cancellous bone (XACB) on tumor necrosis factor-α (TNF-α) expression with avascular necrosis of the femoral head (ANFH) in rabbits. Methods: The models of steroid-induced osteonecrosis in rabbits were randomly divided into five groups: A (model), B (XACB), C (XACB + MSCs), D (XACB + MSCs + LV), and E (XACB + MSCs + LV-FGF-2) groups. The therapeutic effect was evaluated by Hematoxylin and Eosin (H&E) staining. Immunohistochemical and RT-PCR assays were used to detect the protein and mRNA expression of TNF-α in the femoral head, respectively. Results: At 12 weeks after the operation, the defect in rabbits in group E was completely repaired, while defects in rabbits in the other groups were not completely repaired, and the area of new bone formation was higher, when compared with the other groups (P<0.05). Furthermore, the protein and mRNA expression TNF-α was lower at 3, 6, and 12 weeks after surgery, when compared with the other groups, and the difference was statistically significant (P<0.05). Conclusion: FGF-2/MSCs/XACB could promote the repair of ANFH, and may be correlated to the inhibition of TNF-α expression.
Exploring the substellar population in the Hyades open cluster
Authors: Pérez-Garrido A. , Lodieu N. , Rebolo R. , Chinchilla P.
Published: October 2018

Aims. Our aim is to identify substellar members of the nearby Hyades open star cluster to determine the photometric and spectroscopic properties of brown dwarfs at moderately old ages and extend our knowledge of the substellar mass function of the cluster.

Methods. We cross-matched the 2MASS and WISE public catalogues and measured proper motions to identify low-mass stars and brown dwarf member candidates in an area of a radius of ten degrees around the central region of the Hyades cluster. We employed astrometric and photometric criteria, Gaia data, and a maximum likelihood method developed by our group to estimate distances. We selected 36 objects that are candidate Hyades members, 21 of which have not been reported previously.

Results. We have identified 21 new Hyades member candidates that are placed at the lower end of the main sequence. The photometry of 9 candidates places them in the substellar regime, and 2 are at the L/T transition. We also recovered a number of L dwarfs from earlier surveys. Finally, we calculated the mass function for the low-mass population of the cluster and found that the Hyades cluster might have lost 60%–80% of its substellar members.
Blazars in the LOFAR Two-Metre Sky Survey first data release
Authors: Mooney S. , Quinn J. , Callingham J. R. , Morganti R. , Duncan K. , Morabito L. K. , Best P. N. , Gürkan G. , Hardcastle M. J. , Prandoni I. , Röttgering H. J. A. , Sabater J. , Shimwell T. W. , Shulevski A. , Tasse C. , Williams W. L.
Published: October 2018

Historically, the blazar population has been poorly understood at low frequencies because survey sensitivity and angular resolution limitations have made it difficult to identify megahertz counterparts. We used the LOFAR Two-Metre Sky Survey (LoTSS) first data release value-added catalogue (LDR1) to study blazars in the low-frequency regime with unprecedented sensitivity and resolution. We identified radio counterparts to all 98 known sources from the Third Fermi-LAT Point Source Catalogue (3FGL) or Roma-BZCAT Multi-frequency Catalogue of Blazars (5th edition) that fall within the LDR1 footprint. Only the 3FGL unidentified γ-ray sources (UGS) could not be firmly associated with an LDR1 source; this was due to source confusion. We examined the redshift and radio luminosity distributions of our sample, finding flat-spectrum radio quasars (FSRQs) to be more distant and more luminous than BL Lacertae objects (BL Lacs) on average. Blazars are known to have flat spectra in the gigahertz regime but we found this to extend down to 144 MHz, where the radio spectral index, α, of our sample is −0.17 ± 0.14. For BL Lacs, α = −0.13 ± 0.16 and for FSRQs, α = −0.15 ± 0.17. We also investigated the radio-to-γ-ray connection for the 30 γ-ray-detected sources in our sample. We find Pearson’s correlation coefficient is 0.45 (p = 0.069). This tentative correlation and the flatness of the spectral index suggest that the beamed core emission contributes to the low-frequency flux density. We compare our sample distribution with that of the full LDR1 on colour-colour diagrams, and we use this information to identify possible radio counterparts to two of the four UGS within the LDR1 field. We will refine our results as LoTSS continues.
Butterfly diagram of a Sun-like star observed using asteroseismology
Authors: Bazot M. , Nielsen M. B. , Mary D. , Christensen-Dalsgaard J. , Benomar O. , Petit P. , Gizon L. , Sreenivasan K. R. , White T. R.
Published: October 2018

Stellar magnetic fields are poorly understood, but are known to be important for stellar evolution and exoplanet habitability. They drive stellar activity, which is the main observational constraint on theoretical models for magnetic field generation and evolution. Starspots are the main manifestation of the magnetic fields at the stellar surface. In this study we measured the variation in their latitude with time, called a butterfly diagram in the solar case, for the solar analogue HD 173701 (KIC 8006161). To this end, we used Kepler data to combine starspot rotation rates at different epochs and the asteroseismically determined latitudinal variation in the stellar rotation rates. We observe a clear variation in the latitude of the starspots. It is the first time such a diagram has been constructed using asteroseismic data.
Flat grinding model, considering internal dynamics of the process
Authors: Bratan Sergey , Vladetskaya Ekaterina
Published: October 2018

The article considers the results of theoretical studies of the process of flat external grinding on the basis of the developed dynamic model. In order to take into account the influence of the statistical properties of the current deviations of the radius vectors of the grinding wheel and the thickness of the work piece, in addition to the input signal, a random process with the same stochastic characteristics as that of the current deviation of the radius vector of the grinding wheel and the billet topography is fed to the input of the system model. The corresponding random input signal can be obtained by means of a shaping filter. The output coordinate of the shaping filter according to its statistical parameters corresponds to the parameters of the components of the dynamic system characterizing the processes of the grinding wheel effect on the work piece during the grinding process. The developed mathematical model of the operation of flat external grinding can be used to determine the estimates of the quality characteristics of machined parts and systems for automatic control of the process of flat external grinding when the model is supplemented by dynamic links characterizing the statistical properties of the grinding wheel and work piece.
The schemes analysis of profile milling of long and non-technological workpieces
Authors: Gusev Vladimir G. , Fomin Anatoly A. , Saldaev Vladimir A.
Published: October 2018

The article considers alternative schemes of profile milling of long non-technological workpieces – of the peripheral segments, formed during longitudinal opening of logs. Peripheral segments are a large waste of manufacture and contain the wood fibres with high physics-mechanical and operational properties. Therefore manufacturing qualitative wood products from peripheral segments is especially actual problem. However, the named workpieces are characterised by low adaptability to manufacture, therefore working out and the analysis of the machining schemes, expelling a resonance in technological system are necessary. The non-resonance machining scheme is used in a design of the milling machine tool PFP-100 for profile milling of a large wood waste.
Planning the properties of a coated abrasive by quality function deployment
Authors: Syreyshchikova Nelli V. , Guzeev Viktor I.
Published: October 2018

The article presents the procedure for improving the coated abrasive quality using quality function deployment. It shows the results of the process of planning the properties of a coated abrasive based on the consideration of consumer and legislative requirements and operating conditions to achieve the competitiveness of a coated abrasive.
Tool stability analysis for deep hole drilling
Authors: Gorbatyuk Sergey , Kondratenko Valery , Sedykh Larisa
Published: October 2018

A large number of parts have deep holes, therefore, rotary cutting tools, which represent relatively long and thin columns are used for holemaking. In this article we analyze the behavior of such tools under the influence of an axial compression load, in our case, the axial cutting force Fp , which differs fundamentally from the compression of short tools. Moreover, experience shows that when the cutting force Fp reaches a certain critical value equal to Fkp , a long straight column becomes unstable.
Impact of manufacturing errors of ball screw system on performance characteristics
Authors: Denisenko Alexander
Published: October 2018

To convert rotary motion into translational motion in modern metal-cutting machine tools, screw-nut rolling transmissions are widely used. Special requirements are placed on the stability of the operational characteristics of the screw-nut rolling transmission. The influence of the accuracy of manufacturing screw-nut transmission on the main transmission characteristics: axial stiffness and the moment of idling is considered. When analyzing the quality of the manufacture of the transmission, the following manufacturing errors were taken into account: the pitch errors of the screw and nut threads; errors in thread diameter of screw and nut; deviation of the thread profile of the screw and nut; the error of the diameter of the ball. Since these errors are independent random variables, on the basis of the basic propositions of the theory of probability, analytical dependencies were obtained to determine the coefficients connecting the variances of the design parameters and the variance of the probabilistic distribution of the axial force and the idling torque. Based on the calculation results from the obtained dependencies, it was concluded that the errors in the thread pitch of the screw and nut have a prevailing influence on the dispersion of the probabilistic distribution of the axial force (and, consequently, the axial stiffness) and the idling torque. The results obtained allow us to outline further ways of improving the transmission of the screw-nut rolling.
Prevention unstable conditions in the welding process via robotic technological complexes
Authors: Fominykh Dmitry , Kushnikov Vadim , Rezchikov Alexander
Published: October 2018

The article presents the statement of the problem, models and algorithms for controlling the welding process via robotic technological complexes in conditions of the risk of unstable states. The system dynamics model was used to describe the technological process. As system levels the basic indicators influencing quality of the made production chosen on the basis of experience of operation of the robotic technological complexes are taken. Functional dependences between indicators and their dependences on external factors are determined by approximation of statistical data. The procedure of identification of unstable states for the mathematical model on the example of the Rossler’s attractor is developed. An algorithm for preventing the system from falling into unstable states in the process control is proposed
Precision CNC machining and ways to achieve it
Authors: Nekrasov Roman , Putilova Ulyana , Tempel Yulia
Published: October 2018

The quality of the part is characterized by precision of its processing. A good fit of the product parts and, as a consequence, its reliability in general depends on how accurately the size and shape of the part is maintained during machining. In this connection, the article considers the problem of ensuring the accuracy during machining of work pieces using CNC machines. Within the identified problem, the analysis of known technical solutions in this area was carried out and three main areas were identified: optimization of cutting conditions, improvement of the treated surface area according to the criteria for increasing the resistance of the cutting tool, as well as error tracking and correction during machining. The main disadvantages of the analyzed methods and inventions are complexity of their implementation, the need to equip the CNC machine with an adaptive control system, and a limited field of application. Therefore, a method for controlling the accuracy of shaft processing using mathematical and finite element modeling is proposed.
Investigation of the plain milling process dynamic stability taking into account the contact interaction on the flank face of the cutting wedge
Authors: Zhukov Nikita , Kuts Vladimir , Suldin Bogdan
Published: October 2018

The single degree of freedom numerical model of plain milling in time domain is represented in this article. This model allows to take into account the process damping phenomena, which is caused by contact interaction along the cutting edge flank face, on the dynamic behavior of the compliant technological system. The particular feature of this research is the usage of the iterative procedure to make more accurate the solutions on each time step of the modeling, which ensures the fulfillment of stiffness equations in the formula for the contact interaction forces calculation along the cutting edge flank face. The analysis of results, which were obtained using the represented milling dynamics model, shows that the process damping may have a significant influence on the technological system dynamics when machining on the modes with low value of the cutting tooth pass frequency ratio to the natural frequency of the system. The proposed methodology of the contact interaction forces calculation along the flank face of the cutting edge may be developed later on for the 3D multiaxial machining of figurine-shaped workpiece.
An interlocking side mill with retrofittable carbide blades for processing of coarse-pitch tooth wheels
Authors: Artamonov Evgeniy V. , Kireev Vitaliy V. , Zyryanov Vitaliy A.
Published: October 2018

Nowadays Russian manufacturers of metal-cutting tools for machine-building industry do not offer structures of prefabricated cutting hobs with retrofittable carbide blades for processing of tooth wheels, though usage of retrofittable carbide blades allows to increase significantly working capacity and productivity of the processing. As of today creation of an assembly cutting tool for processing of tooth wheels with the retrofittable carbide blades is a big step forward for machine-building industry. A high quality tool allows warranting for a new equipment and making work of operators more productive. This paper offers a new technical solution providing increase of efficiency of processing by assembly tools with the retrofittable carbide blades made of a hard alloy. Due to usage of progressive cutting patterns division of a margin for straight-line segments and curved sections is performed. This division has a positive impact on cutting hard-alloy inserts and also reduces their wear and tear.
The influence of hydrojet surface processing on the adhesive strength of wear-resistant coatings deposited on a metal-cutting tool of oxynitride ceramics
Authors: Seleznev Anton , Smirnov Anton , Peretyagin Pavel
Published: October 2018

The work represents a new approach of preliminary surface treatment of replaceable polyhedral cutting ceramics inserts for significant increase of adhesion strength with deposited wear-resistant nitride ceramics. By this method the hydrojet treatment was used to repair surface defects occurring during manufacturing process of any required geometry of cutting inserts.
Analysis of possibilities of high-speed prototyping technology in hot section manufacturing
Authors: Balaykin Andrey V. , Vdovin Roman A. , Dobryshkina Elena M.
Published: October 2018

The article is devoted to the exercising of a trial technological process for the manufacture of gas turbine engine (GTE) hot sections by the example of a solid-cast nozzle block. To do this, the authors made up a plan of the experiment associated with the search for optimal conditions and parameters of a technological process of the sector master mold layer-by-layer synthesis from a photopolymeric material. The paper tracks the interconnection between the parameters of a 3D printing system Objet Eden 350 and the materials in the growing process by the PolyJet technology and mechanical properties of a master mold in the context of their influence on the surface layer quality and geometric accuracy of the final GTE parts’ casting. Based upon the analysis of the obtained research results and taking into account technical requirements, the authors managed to grow a nozzle block sector master mold, get wax models and conduct an experimental casting of a solid cast nozzle block wheel.
On-line diagnostics of the physical and mechanical properties of the surface at the production stage
Authors: Kraynev Dmitriy , Tikhonova Zhanna , Bondarev Alexander
Published: October 2018

The article deals with the issues of increasing the efficiency of the formation of the performance of the surface layer of machine parts. The results of computer modeling of thermophysical processes in the cutting zone are presented. The possibility of controlling the process of formation of the surface layer structure on the basis of the measurement of the thermal EMF, which make up the cutting forces, as well as the vibro-acoustic signal is considered.
Use of additive technologies to increase effectiveness of design and use of a vacuum gripping devices for flexible containers
Authors: Makarov Alexey M. , Mushkin Oleg V. , Lapikov Maksim A.
Published: October 2018

In an effort to increase efficiency of the process of handling of an air-penetrating flexible container during its’ filling with free-flowing materials a devise has been designed for automatic gripping, opening, holding and sealing of flexible container, containing vacuum gripping devise, pneumatic drive for its’ transfer and a control system based on programmable logical controller. Vacuum gripping device can be produced using the method of additive technologies. It has a modular structure, while each module contains random or structured vacuum chambers located on work surface area, connected to a system of internally branched channels with the source of vacuum. Large number of small vacuum chambers in place allows to minimize leakage of air though pores and openings on the surface of the mouth of weaved flexible container, which increases reliability of holding and reduces energy consumption during the process of handling air-penetrating packaging during its’ filling.
Improving the accuracy of machining of non-rigid shaft
Authors: Drachev Oleg , Bobrowskii Alexander , Zotov Alexey
Published: October 2018

So far, due to much more strict events of operating parameters requirements, the reduction of pieces steel intensity allows to produce multiplying quantity of the highly precise Non-Rigid Pieces (NRP); most of them are supposed to be the shafts in amount. The creation of Automatic Control Systems (ACS) by mechanical operating also involves highly precise NRP production. In present paper there is Self-Centering Rest (SCR) operating hydrocylinder piston rod control system presented; it causes influence directly to the rest centering accuracy. The plant processing does not require hydrostation and pipeline; it possesses highly precise centering and it is able to function either in shaft support mode, or in active dampening one. There is the original scheme of double acting sealed hydrocylinder presented. There is the functional control scheme of hydraulic power cylinder presented. There are results of the non-rigid shaft axle research while turning presented. Thus, the beat reduction of the rigid shaft while turning in SCR system reaches 3...16 times in comparison.
Algorithm for recognition of details in the machine vision systems at automation of assembly processes
Authors: Kulkov Yaroslav , Zhiznyakov Arkady , Privezentsev Denis
Published: October 2018

The aim is an experimental research on the flat objects recognition using dimensionless marks of the contours of their binary images and determining the possibility of applying this method in computer vision systems of assembly robots. The main problem with the automation of assembly operations is the recognition of parts for the subsequent picking up of the robot arm. The basis for the formation of attribute vectors is the characteristics of the image contour. Recognition of a class of an unknown object consists in receipt of its contour, calculation of primary parameters and forming of a vector of dimensionless marks. Further mean square deviations of its vector of dimensionless marks from all reference are calculated. The minimum value of a deviation will specify probable belonging to the corresponding class.
Integrated approach to providing for environmental friendliness and safety of the technological processes
Authors: Shvartsburg Leonid , Yagolnitser Olga , Butrimova Elena
Published: October 2018

Basing on energy-related analysis, the article discusses the issues of creating integrated approaches to providing for environmental friendliness and safety of the technological processes of form-shaping and the methodology of quantitative evaluation of ecological effectiveness of these processes. Energy-related analysis allows to find the interrelations between energy efficiency and environmental friendliness of technological processes, to create a joint methodology for improving these indices by reducing energy losses and compensating the “underload” of electric motors of processing equipment. The established interrelations allowed to compose the integrated ecological quality index, making possible to estimate numerically the environmental friendliness and safety of technological processes for each particular implementation. As an example, the article presents the formation of a comprehensive criterion for environmentally justified selection of LCTA and systems for LCTA application as one of the possible approaches to detailing of environmental friendliness and safety of technological processes based on rational choice of LCTA.
Analysis of the applicability of filtration methods for coordinate measurements
Authors: Grechnikov Fedor V. , Kochetkov Andrei V. , Zakharov Oleg V.
Published: October 2018

At present, surface metrology solves such important tasks as monitoring the production process and optimizing the exploitation of parts. A significant part of the measurements is performed by a contact method using Coordinate Measuring Machines. One of the important steps in the processing of measurement information is the filtration of the received signal. The existing standards regulate only the processes of measuring roundness and roughness. Therefore, researches on the applicability of filtration methods in the general case for coordinate measurements are relevant. Based on the review presented in the article, the filters that have received the greatest application in other fields of technology are defined by the strategy of their application for coordinate measurements. It is recommended to use the following sequence: elimination of gross errors based on the Grubbs’ test, discrete Fourier transform for revealing systematic errors, elimination of systematic errors from the signal, minimization of the random error with the bilateral Gaussian filter, surface reconstruction after filtering based on inverse Fourier transform. The above example of signal filtering for flatness confirmed the effectiveness of the proposed approach.
Strengthening of materials by vibroimpact and combined methods with previous electrochemical processing
Authors: Boldyrev Alexander I. , Boldyrev Alexander A. , Fedonin Oleg N.
Published: October 2018

The authors examine capabilities of vibroimpact strengthening after electrochemical processing of materials, also getting guaranteed cold work of the surface during simultaneous anodic dissolution and mechanic calibration. They propose the technique of electrochemical mechanical processing. This article contains the results of experimental investigations. This technique passed evaluation test during production of shell cases with high accuracy and guaranteed hole cold work. The received results give ground for affirmation that electrochemical processing that proceeds hardening enables great extension of technological capabilities of this method and successful continuation investigations directed at creation of lighter constructions with higher ultimate resistance at reversed loads.
The simulation of cold volumetric stamping by the method of transverse extrusion
Authors: Belan Anatoly K. , Nekit Vladimir A. , Belan Olga A.
Published: October 2018

The article is devoted to the theoretical study and development of the production process of manufacturing rod products with larger heads by transverse extrusion. For carrying out researches the elastic-plastic finite-element model based on the variation principle was chosen. This model, due to the development of a complex of boundary and initial conditions, has been adapted to the scheme of volume stamping of the fasteners and implemented in the form of a software package in the system DEFORM 3D. The paper presents the results of computer simulation of the technology of manufacturing the mortgage bolt
Determination of shrinkage of weld
Authors: Velikanov Nikolay , Koryagin Sergey , Sharkov Oleg
Published: October 2018

A calculation-experimental technique of determination of weld shrinkage is described in that work. Experimentally, with the help of strain gauges, residual stresses are determined at two points, which are at known distances from the weld. Shrinkages are found out from the theoretical solution of the plane elasticity theory about the insertion of bodies with interference. Calculations have been carried out for experimental studies of a weld 400 mm long for different thicknesses of metal. It is found that when the thickness of the metal increases, the shrinkage values also increase. This is due to the fact that as the thickness of the metal increases, the heat input required to penetrate it also increases.
Mathematical model for determining rational machining conditions for flat grinding with the wheel periphery on machines with a rectangular table
Authors: Skuratov Dmitriy L. , Fedorov Dmitriy G. , Evdokimov Dmitriy V.
Published: October 2018

A mathematical model is presented for determining the rational machining conditions for flat grinding operations by the rim of a wheel on machines with a rectangular table consisting of a linear objective function and linear inequality constraints. As the objective function, the equation, determining the main machining time, was used. And constraints which are related to the functional parameters and parameters determining the machining quality and the kinematic capabilities of the machine were used as inequality constraints.
Optimization of modes for processing water-ice cleaning of machine parts
Authors: Burnashov Mikhail , Prezhbilov Alexander
Published: October 2018

At present, the development of technologies for cleaning various surfaces from coatings, contaminants and deposits is very relevant. It becomes even more important when the coating material has to be prepared for a secondary use, and in respect of the surface being cleaned its physical and mechanical properties and shape are not allowed to change.
Method of developing parametric machine cycles for modern CNC systems using high-level language
Authors: Pushkov Roman , Salamatin Evgeniy , Evstafieva Svetlana
Published: October 2018

The article deals with the questions connected with the technique of developing standard technological cycles by the example of milling a circular spigot. The sequence of cycle development is given, key development moments are highlighted, examples of implementation are given. An interface has been implemented for the possibility of convenient input of cycle parameters.
Vacuum methods of surface treatment with subnanometer roughness
Authors: Panfilov Yury , Kolesnik Leonid
Published: October 2018

Vacuum methods of surfaces with 1 nm or less roughness treatment were analyzed.Physical models of super sleek surfaces polishing into vacuum cambers by means of ion beam etching and thin film deposition and ion cluster treatment were shown.The results of experimental research of ion cluster polishing with differentregimes were represented.Prospects of surface treatment with subnanometer roughness by means of vacuum methods are represented.