bluuebunny/crossref_metadata_2025 huggingface dataset:
The methodology of the development of original medicines based on the medicinal plant raw material for the treatment of inflammatory bowel diseases
Authors: Shmalko O. O.
Published: September 2023

According to the Ministry of Health of Ukraine, the number of patients with IBD in Ukraine is approximately 30,000 people per 100,000 population, half of which have a medium or severe degree of damage.

Over the past 5 years, there has been a trend towards an increase in the number of severe cases and treatment-resistant forms of chronic intestinal diseases of an inflammatory nature, which often requires surgical intervention or causes the development of complications, which, in turn, can lead to invalidation of patients and, as a result, causes significant economic costs, related to their care, treatment and rehabilitation. The most common are Crohn’s disease and ulcerative colitis.

The prevalence of ulcerative colitis (UC) in the population ranges from 21 to 268 cases per 100,000 people. The social significance of UC lies in the fact that the incidence is predominant among young people. Thus, statistical data show that the peak incidence of UC occurs at the age of 20–30 years. In the absence of appropriate therapy, the course of UC is recurrent and remitting.

In the process of work, the methods of analysis of electronic and paper sources of information were used, on providing the domestic pharmaceutical market with drugs for the treatment of IBD, their directions and mechanism of action, the possibility of using in the therapy of diseases with herbal medicines containing BAS, that affect various links of the pathogenetic process, the possibility of combining it with synthetic API in order to increase the effectiveness of treatment.

The algorithm of the methodology consists of three blocks: information and search, research and biological. Each block, which ends with obtaining an intermediate result, ensures the setting of the task for the next stage of the research.
Analysis of Financial Structure on Profitability and Non-Financial Performance in Industrial Companies
Authors: Supardi Supardi , Sriyono Sriyono , Hermawan Sigit
Published: September 2023

Non-financial performance can be used to determine the success of the company and show the growth of a company. This study aims to examine and analyze the effect of Financial Structure (Working Capital, Asset Structure, and Operating Leverage) on Profitability and Non-Financial Performance in Industrial Companies. The sampling method used is the census method, which is a comprehensive sampling of 15 companies with a 3-year research period from 2019 to 2021. Method A the analysis is with method Partificial Least Square (PLS) using the Smart program PLS 2.0. The results of the analysis show that working capital and asset structure have an effect on profitability. Working capital, asset structure and operating leverage have no effect on non-financial performance. Profitability has an effect on Non-Financial Performance. Profitability mediates the effect of Working Capital and Asset Structure on Non-Financial Performance. Profitability does not mediate the effect of Operating Leverage on Non-Financial Performance. The result shows, that all proposed hypotheses are accepted except Hypothesis High Operating Leverage does not affect the Company's Non-Financial Performance. The company can grow and develop, and can increase the company's profitability by increasing its own capital and reducing some of the company's debt. Non-financial performance can be improved by providing fast, good, and satisfying service to consumers.
Keywords —Working Capital; Asset Structure; Operating Leverage; Profitability; Non-Financial Performance
Survey Impact of COVID on Work-Family Conflict (WFC) and Flexible Work Arrangement (FWA)
Authors: Ayuningtias Hani Gita , Nurbaiti Annisa , Hendayani Ratih , Setiadi Setiadi
Published: September 2023

Covid is mandating that all businesses around the globe be able to accommodate flexible work schedules. In addition, many companies are instituting work-from-home policies due to social interaction restrictions. This condition makes it difficult for businesses to establish explicit FWA regulations. The implementation of a WFA presents numerous obstacles, particularly concerning WFC. Certain conditions will have a negative impact on employees who are tasked with completing work in addition to domestic responsibilities. If no distinct rules govern this, it will be difficult for employees to manage their time, negatively impacting employee performance. Members continue to believe that the FWA settings are not optimal one year after the pandemic has begun. Many employees still confront WFC when completing work and homework simultaneously. This condition stipulates that implementing FWA must be enhanced to reduce the risk of WFC. The data acquisition method is a survey of 100 employees in the manufacturing industry that produces steel. According to the study's findings, the Work-Family Conflict (WFC) was in the lowest category, with employees believing that the tasks assigned are balanced between work and family to avoid creating work-family conflicts. While the FWA implementation was rated acceptable, it makes it easier for employees to manage their time more flexibly to complete their work. The obtained results can assist the organization in enhancing its procedures for implementing the FWA.
Keywords—Work-Family Conflict; Flexible Work Arrangement
Wearable Wireless Sensor Network for Mitigating COVID-19 Transmission Through Physical Distancing
Authors: Niswar Muhammad , Andani  , Fachrurrozie Haris Muhammad Ahlan , Basuki Achmad
Published: September 2023

The global community is currently facing a critical situation with the widespread transmission of the Covid-19 virus. The rapid increase in Covid-19 cases has necessitated immediate action and treatment. As the World Health Organization (WHO) recommended, maintaining a minimum distance of one meter between individuals is an effective preventive measure to avoid transmission through respiratory droplets. To address this issue, this paper introduces a cost-effective design and implementation of a wearable wireless sensor network using the ESP32 microcontroller and Bluetooth Low-Energy (BLE) technology that promotes physical distancing and contact tracing to mitigate the spread of COVID-19. In this research, we have determined that the safe distance between individuals is 1.5 meters. Proximity testing has indicated that an RSSI value of -62 dBm corresponds to a distance below 1.5 meters. Hence, we set -62 dBm as the distance threshold between wearable devices to ensure safe physical distancing. These wearable wireless sensor network devices are intended to assist individuals in maintaining a safe distance from others, thereby reducing the risk of COVID-19 transmission.
Comparative Analysis of the Use of State Management in E-commerce Marketplace Applications Using the Flutter Framework
Authors: Akhmad Dinan Jatnika Aditya , Akbar Muhammad Aminul , Pinandito Aryo
Published: September 2023

This research aims to analyze the performance of two popular state management tools that have different system approaches, namely Riverpod and GetX, in developing marketplace applications using the Flutter framework. The marketplace type application used is Flutter ecommerce which is available as open source on the GitHub platform. This research aims to provide benefits to Flutter application developers in choosing the right state management tools for marketplace applications. The method used is to compare memory usage, execution time and CPU utilization of the two tools. Testing is done on the feature of displaying the home screen, search and add features. The results of the analysis obtained are that there are differences in memory usage and execution time for the three features and scenarios, GetX provides less memory usage with faster execution time. While in CPU utilization, there tends to be no performance difference between GetX and Riverpod. The conclusion is that GetX state management uses memory more efficiently and is able to provide faster execution time than Riverpod state management with better performance.
User Experience Design for Information Technology Career Preparation Platform Using the Design Thinking Method
Authors: Tri Ananta Mahardeka , Fanani Lutfi , Adista Sihombing Ivanna , Abidin Zainul
Published: September 2023

Digital talent is crucial in the thriving Information Technology (IT) industry. Hence, numerous countries seek digital skills to stay competitive in the current era. In Indonesia, the challenge lies not in quantity but in the readiness of digital talents to enter the professional world. To address this issue, we observed the IT career readiness of fresh graduates and senior students from the Faculty of Computer Science, Universitas Brawijaya. The observation revealed that 82.9% of 70 respondents stated doubts about their career preparations in the IT domain. These doubts stemmed from perceived inadequacy in technical skills, lack of readiness in developing a curriculum vitae and facing job interviews. Given the need for career preparation in the IT domain, we address the development of a platform to assist aspiring IT talents. This study proposes a solution as an IT career preparation application designed using the Design Thinking method The proposed design was tested using the Usability Evaluation, yielding an effectiveness rate of 100% and an efficiency value of 0.08 goals/sec. Furthermore, a satisfaction test was conducted using the SUS questionnaire, resulting in a score of 94.75 (excellent).
User Experience Design Sales Performance and Sales Person Productivity Application MTFSales Using Human Centered Design Method (Case Study: PT Mandiri Tunas Finance)
Authors: Eldi Romadhona Safira , Rokhmawati Retno Indah , Priharsari Diah
Published: September 2023

PT Mandiri Tunas Finance is a company engaged in financing new or used cars, motorcycles, and commercial vehicles, with a network of 102 branches spread throughout Indonesia. In its business process, sales performance monitoring is still considered ineffective, because the information about sales performance is in the form of an excel calculated manually. The salesperson could not monitor it directly. This study aims to produce a MTFSales application design using Human Centered Design. The prototype was tested using the user testing method and the SUPR-Q questionnaire. The results of the test using user testing are positive results with some suggestions from users. The test results using the SUPR-Q method for sales officers are 88.19%, sales heads are 88.65% and branch managers are 83.81%. All three are in the excellent and acceptable categories so it can be said that the design can be accepted by the users.
Establishing the Standards and Categories in Distinguishing Diacritics from Letters in Arabic and English
Authors: Ismael Waqqas Saadi , Badie Muthana Mohammed
Published: September 2023

A diacritical mark is a mark which is put above or below the letter. That is to say, diacritical marks are seeming letters that play a vital role in attributing words to different classes. According, they can change the syntactic function as well as the part of speech of the words they are used with. Thus, they are dealt with by different fields of linguistics, such as phonetics, syntax, and so forth. However, the current study aims at investigating the importance of these marks in English and Arabic to show how important these marks are and how similar universally each language with the other(s). In addition, the study comes against the long-adopted view of the importance of these marks in language.
Prepositions: Learning Difficulties of a Semantically-Oriented Part of Speech
Authors: Mustafa Ibrahem Muhammed Ali , Alnuaimi Hashim Saadoon Saleem
Published: September 2023

The learners of English mostly face difficulties in selecting the right preposition for a sentence in speech and in writing. The wrong choice of preposition could occasionally be ascribed to interference and overlap caused between the mother tongue and the target language. One more difficulty may emerge when a single preposition may possibly have more than one semantic use. It is hypothesized that the linguistic differences between English and Arabic could be the reason behind impeding the learners of doing well in the target language. The learners, therefore, may unconsciously covey the Arabic linguistic habits to English although the syntactic and semantic characteristics between the two languages are totally different. The researchers
Antibacterial activity of Ricinus communis against somebacteria isolated from wastewater
Authors: S. Aswed Hussein , A. Abdul-Gabar Reidh , A. Burhan Salah
Published: September 2023

This study was conducted at the North Gas Company in Kirkuk during the period from Nov. 2001 - July 2002. Four stations were chosen for sampling collections. The samples chosen from ; station (1) before treatment,and three stations from the treatment unit (production unit ;control unit; and general unit ). Four bacterial species (10 isolates for each) staphylococcus aureus;Enterococcus faecalis; Escherichia coli; and Pseudomonas aeruginosa were isolated.Results of the present study showed that minimum inhibitory concentration (MIC) of alcoholic extract for Gram positive bacteria isolates was (4 - 8 mg/ ml), while it was 4 - 16 mg/ ml for Gram negative bacteria
Interactive documentaries: definition of the concept in Russian and foreign studies
Authors: Cherednichenko Lyudmila
Published: September 2023

The article provides an overview of modern Russian and foreign studies considering the concept of "interactive documentary" (interactive documentary, i-docs, idoc) and related terms: "web documentary" (web documentary, web-doc, webdoc), "interactive documentary". Theoretical foundations are given, approaches to the definition of these concepts are briefly described. The study uses descriptive, informative, comparative and structural-functional methods to solve a scientific problem. The research material was the works of Russian, American, British, Spanish, Turkish and Chinese scientists from 2011-2023. The most common, frequently cited and used definitions were selected for the review. The author of the article draws attention to the terminological uncertainty in the field under study, identifies the problems associated with defining the boundaries of the concept of "interactive documentaries", highlights the most promising aspects in identifying the characteristics of this new phenomenon and outlines directions for further research. As a result of the research, the author comes to the conclusion that due to the multimodality, complexity, openness and dynamism of the form of interactive documentaries, it would be appropriate to designate this phenomenon as a meta-genre. The proposed research lays the prerequisites for further search for the most accurate definition of interactive documentaries, corresponding to the current level of media development, accumulated theoretical and creative experience.
Investigating Online Versus In-Person Learning on Student Performance
Authors: Singh Upasana , Naidoo Mergan , Mtapuri Oliver , Petrus Ruwayda , Gibson Sarah , Arek-Bawa Oreh
Published: September 2023

The urgent transformation from face-to-face teaching to an online format in Higher Education Institutions (HEIs) worldwide was carried out overnight, and almost seamlessly as a result of the COVID-19 pandemic. While the transition to adopting online assessment methods may have proved challenging for academics, recent literature in this area highlights the main reason for this—that many face-to-face universities had never implemented any form of online assessment from an institutional perspective prior to the pandemic. This issue was further exacerbated by the fact that these assessments had to be conducted remotely, bringing to the fore extraordinary challenges for HEIs, including academic dishonesty, infrastructural limitations, coverage of learning outcomes, and commitment of students to submit assessments, to name but a few. The overarching purpose of this research was to determine which teaching method proved more effective over the eight-year period. The scores of 548 students—401 traditional students and 147 online students—in an environmental science class were used to determine which instructional modality generated better student performance by means of a comparative study. This article adopts a quantitative approach analysing retrospective data at the selected institution to determine the performance of undergraduate students during the first and second semesters of 2019, when the institution operated in a fully face-to-face environment, and compares these results with those achieved during the first two semesters of 2020, during which the institution adopted emergency remote teaching and assessment as a result of the COVID-19 pandemic. The purpose of this article was to determine whether students performed better or worse in the online environment. Results from institutional-wide modules were compared across the two years.
Molecular analysis with pancreaseq® in evaluation and management of pancreatic cysts: A cohort of 28 patients
Authors: Ardor Gokce Deniz , Hanna Helena , Ozalp Bora , Nassar Aziza
Published: September 2023

Objectives:

Herein, we present the PancreaSeq® results of 28 patients and emphasize the usefulness of molecular testing in evaluation of pancreatic cysts.

Material and Methods:

A total of 10 (35.7%) non-diagnostic, 6 (21.4%) negative, 5 (17.8%) atypical, and 7 (25%) were positive for mucinous cystic neoplasm (MCN) pancreatic cyst aspirates were analyzed with PancreaSeq® at Mayo Clinic, Jacksonville between September 2021 and February 2023.

Results:

Three non-diagnostic, two negative, three atypical, and two positive for MCN cysts were positive for KRAS and GNAS mutations. They were interpreted as intraductal papillary mucinous neoplasm (IPMN) with low risk for progression to high-grade dysplasia/adenocarcinoma. One negative case was positive for KRAS and GNAS mutation and RNF43 copy number alteration. It was interpreted as IPMN with a low risk of progression. Two non-diagnostic, one negative, and two positive for MCN cysts were positive for KRAS mutation. All were interpreted as IPMN/MCNs with low risk of progression. One positive for MCN case was positive for GNAS mutation and ALK fusion and one positive for MCN case was positive for GNAS mutation, ALK fusion, and RNF43 copy number alteration. Both were interpreted as IPMN and their risk of progression was interpreted as not well understood. One atypical case was positive for KRAS and TP53 mutation and was interpreted as IPMN/ MCNs with a high risk of progression. VHL mutation was present in one non-diagnostic case. It was interpreted as serous cystadenoma and the risk for progression was low.

Conclusion:

Molecular analysis of pancreatic cysts with PancreaSeq® is useful in accurate diagnosis, especially when cytologic material is non-diagnostic and helps improve patient management.
Ruptured small cerebral aneurysm occurring at the fenestration of the A1 portion of the anterior cerebral artery, combined with accessory middle cerebral artery branching from the crus: A case report
Authors: Kimura Seigo , Komiyama Masaki , Taniguchi Hirokatsu , Wanibuchi Masahiko
Published: September 2023

Background:

Cerebral aneurysms arising from fenestration of the A1 portion of the anterior cerebral artery (ACA) (A1 fenestration) with the accessory middle cerebral artery (MCA) is rare. Herein, we report a ruptured cerebral aneurysm arising from A1 fenestration combined with the accessory MCA that was successfully treated with coil embolization.

Case Description:

A 51-year-old woman suddenly experienced a severe occipital headache and was admitted to our hospital. Detailed examination revealed subarachnoid hemorrhage due to a cerebral aneurysm arising from A1 fenestration combined with the accessory MCA. Hence, coil embolization was performed, and a favorable outcome was obtained.

Conclusion:

Coil embolization of the cerebral aneurysm arising from the A1 fenestration of the ACA combined with the accessory MCA is considered to be useful.
Strategy of cerebral endovascular treatment for cervical internal carotid artery stenosis with a persistent primitive hypoglossal artery
Authors: Yoshida Shinichiro , Kamatani Kaisei , Takigawa Kousuke , Tashiro Noriaki , Hashiguchi Yoshiya , Yasaka Masahiro , Aikawa Hiroshi , Go Yoshinori , Kazekawa Kiyoshi
Published: September 2023

Background:

Persistent primitive hypoglossal artery (PPHA) is a rare residual arterial anastomosis. We placed a CASPER stent using Spider FX as an embolic protection device (EPD) in a patient with internal carotid artery (ICA) stenosis and PPHA. There are no reports of carotid artery stenting (CAS) using a CASPER stent for ICA stenosis with PPHA. We report the EPD strategy used in this case and the usefulness and precautions of CASPER stent insertion for cervical ICA stenosis in association with PPHA.

Methods:

A 9Fr sheath was placed in the right femoral artery and a 9Fr Branchor balloon guide catheter was guided to the common carotid artery. A Spider FX was placed proximal to the bifurcation of the ICA and the PPHA. A 10 mm × 20 mm CASPER stent was deployed at the site of the stricture with no postoperative ischemic complications.

Results:

There was no intra-stent occlusion, stenosis, or plaque protrusion immediately after surgery, and no postoperative ischemic complications were observed.

Conclusion:

CASPER stent deployment with the Spider FX in the ICA and PPHA bifurcation can be considered to be an effective treatment method for ICA stenosis associated with PPHA. However, care should be taken in selecting the appropriate EPDs and stents depending on the location of the stenosis and bifurcation of the PPHA.
The impact of tax policy on the financing of the education system in the regions of Russia
Authors: Арсаханова З.А.
Published: September 2023

Российская система образования в последние годы столкнулась с серьезными проблемами, особенно в области финансирования. В статье исследуется влияние налоговой политики на финансирование образования в регионах России. В частности, исследуется текущая налоговая политика в России и то, как финансируется система образования. Также исследуются проблемы, связанные с финансированием образования в регионах России. Затем в статье рассматривается, как налоговая политика влияет на финансирование образования в этих регионах, включая различия в финансировании образования между регионами с разной налоговой политикой. Кроме того, исследуются потенциальные преимущества и недостатки различных налоговых политик в отношении финансирования образования. Статья завершается рекомендациями по улучшению финансирования образования в регионах России, в том числе возможными политическими решениями и корректировками налоговой политики для лучшей поддержки финансирования образования. Инвестиции в финансирование образования в регионах России имеют значительные долгосрочные преимущества.

The Russian education system has faced serious problems in recent years, especially in the field of financing. The article examines the impact of tax policy on the financing of education in the regions of Russia. In particular, it examines the current tax policy in Russia and how the education system is funded. The problems related to the financing of education in the regions of Russia are also investigated. Then the article examines how tax policy affects the financing of education in these regions, including the differences in the financing of education between regions with different tax policies. In addition, the potential advantages and disadvantages of various tax policies in relation to education financing are investigated. The article concludes with recommendations for improving the financing of education in the regions of Russia, including possible policy decisions and adjustments of tax policy to better support the financing of education. Investments in the financing of education in the regions of Russia have significant long-term benefits.
The role of the student in the educational process: participation in conferences
Authors: Быкова И.В. , Зяблова Е.С. , Удовенко Е.В.
Published: September 2023

Сегодняшний темп жизни набирает большие обороты, давая понять, что люди должны успевать менять себя, свои привычки и уметь быстро адаптироваться к определенным изменениям, которые возникают в обществе. ХХІ век – время стремительного развития инноваций и техники, понимая, что такие процессы являются необратимыми. Встает вопрос - может ли сегодняшний студент совместить в себе два важных направления: науку и активность. Исследуя различные аспекты деятельности студентов, можем сделать вывод, что данную проблему не рассматривали как совокупность факторов, что дает нам возможность исследовать эту проблему более основательно. Наука – это деятельность в системе общественного разделения труда, направленная на получение нового знания с целью оптимизации всей остальной человеческой деятельности. Наука в ее современном понимании возникает постепенно. Активность человека является источником его развития, определяет деятельность и является его движущей силой. Принципиальное различие между этими понятиями состоит в том, что деятельность исходит из потребности в предмете, а активность – из потребности в деятельности. К тому же активность вроде бы предшествует деятельности во времени: до начала деятельности мы активно выбираем, что именно желательно, свободно планируем, думаем, с помощью каких средств чего-то достичь. Но активность не только предшествует деятельности, но и “сопровождает” ее на протяжении всего процесса. Нельзя представить оптимальную деятельность, лишенную активности.

Today's pace of life is gaining momentum, making it clear that people should have time to change themselves, their habits and be able to quickly adapt to certain changes that arise in society. The 21st century is a time of rapid development of innovation and technology, realizing that such processes are irreversible. The question arises whether today's student can combine two important areas: science and activity. Examining various aspects of students' activities, we can conclude that this problem was not considered as a set of factors, which gives us the opportunity to investigate this problem more thoroughly. Science is an activity in the system of social division of labor aimed at obtaining new knowledge in order to optimize all other human activities. Science in its modern understanding arises gradually. Human activity is the source of his development, determines activity and is his driving force. The fundamental difference between these concepts is that activity comes from the need for an object, and activity comes from the need for activity. In addition, activity seems to precede activity in time: before the start of activity, we actively choose what is desirable, freely plan, think by what means to achieve something. But activity not only precedes activity, but also “accompanies” it throughout the entire process. It is impossible to imagine an optimal activity devoid of activity.
Electronic technologies for learning foreign languages
Authors: Коннова О.В. , Романова И.В.
Published: September 2023

Актуальность выбранной темы обусловлено необходимостью распространения знаний о понимании возможных методов изучения иностранных языков в современном мире. Авторы анализируют различные точки зрения на целесообразность применения электронных технологий в обучении иностранному языку и выражают целостную позицию по данному вопросу. В статье рассматриваются как положительные, так и отрицательные стороны внедрения электронных методик обучения в образовательный процесс. В статье рассматриваются различные аспекты, такие как использование компьютерных программ, интерактивных учебных платформ, онлайн-ресурсов и мобильных приложений для эффективного изучения языков. Авторы анализируют преимущества и ограничения электронных технологий в контексте обучения иностранным языкам, а также обсуждают вопросы эффективности и результативности такого подхода. Статья является полезным ресурсом для преподавателей и исследователей, интересующихся применением современных технологий в образовании и изучении иностранных языков.

The relevance of the chosen topic is due to the need to disseminate knowledge about the understanding of possible methods of learning foreign languages in the modern world. The authors analyze various points of view on the expediency of using electronic technologies in teaching a foreign language and express a holistic position on this issue. The article discusses both positive and negative aspects of the introduction of electronic teaching methods in the educational process. The article discusses various aspects, such as the use of computer programs, interactive learning platforms, online resources and mobile applications for effective language learning. The authors analyze the advantages and limitations of electronic technologies in the context of teaching foreign languages, as well as discuss the effectiveness and effectiveness of such an approach. The article is a useful resource for teachers and researchers interested in the use of modern technologies in education and learning foreign languages.
Power Over Architecture
Authors: Andi Uray Fery , Irwin Irwin , Zain Zairin , Pebriano Valentinus , Andi Andi
Published: September 2023

The notion of power, characterized by its ability to wield influence over others as guided by its holder’s intention, is intertwined with a spectrum of social control mechanisms encompassing force, coercion, manipulation, seduction, and authority. Malay sultanate palaces in West Kalimantan were a form of architecture hinggil (high) culture. The historical development of Malay ethnics in West Kalimantan is linked to power dynamics. This study investigates the historical development of Malay Sultanate palaces’ spatial configurations and architectural designs. It focuses on the colonial era, during which power dynamics exerted significant influence. This paper aims to ascertain the extent to which power dynamics have shaped the architectural aspects of the Malay Sultanate palaces. The analysis highlights the architectural objects and employs a historical methodology with diachronic and synchronic analyses to discern the patterns of power prevalent throughout the Sultanate’s history. Power is palpably demonstrated in effecting substantial transformations in the intent and function of the sultanate palaces, often through manipulation, seduction, and assertion of authority. These power dynamics are exemplified through architectural modifications, i.e., the controleur strategic placement and fort within the Sultanate’s vicinity, interior space reconfigurations, alterations in functionality, and symbolic embellishments reflecting the Sultanate’s authority. The colonial administration from the Dutch regime embarked on fortifying its dominion through modifications to the functional underpinnings of the palace chambers. The Dutch authority’s influence facilitated the consolidation and validation of their control. These mechanisms engendered compliance and acquiescence to the dominion of the ruling party through latent means.
A “Neat” Synthesis of Substituted 2-Hydroxy-pyrido[1,2-a]pyrimidin-4-ones
Authors: Gaube Gregory , Mutter James , Leitch David
Published: September 2023

We report the synthesis of a series of substituted 2-hydroxy-pyrido[1,2-a]pyrimidin-4-ones through solvent-free condensation of of 2-aminopyridines and diethyl malonate. This method is contrasted with three reported general procedures for the preparation of these compounds, revealing the simple, “neat” synthesis conditions are suitable for a number of derivatives. Environmental, safety, and economic factors were considered in exploring this effective and robust synthetic method.
Oxygen-Resistant CO2 Reduction Enabled by Electrolysis of Liquid Feedstocks
Authors: Pimlott Douglas , Jewlal Andrew , Kim Yongwook , Berlinguette Curtis
Published: September 2023

Electrolytic CO2 reduction fails in the presence of O2. This failure occurs because the reduction of O2 is thermodynamically favored over the reduction of CO2. Consequently, O2 must be removed from the CO2 feed prior to entering an electrolyzer, which is an expensive process. Here, we show the use of liquid bicarbonate feedstocks (e.g., aqueous 3.0 M KHCO3), rather than gaseous CO2 feedstocks, enables efficient and selective CO2 reduction without additional procedures for removing O2. This advance is made possible because liquid bicarbonate solutions deliver high concentrations of captured CO2 to the cathode, while the low solubility of O2 in aqueous media maintains a low O2 concentration at the same cathode surface. Consequently, electrolyzers fed with liquid bicarbonate feedstocks create an environment at the cathode that favors the reduction of CO2 over O2. We validate this claim by electrochemically converting CO2 into CO with reaction selectivities of ~65% at 100 mA cm-2 using 3.0 M KHCO3 solution bubbled with 100% CO2 or 100% O2. Similar experiments performed with a gaseous CO2 feedstock showed that merely 1% of O2 in the feedstock reduced CO selectivity to 11 ± 3.7%. Our findings demonstrate that a liquid bicarbonate feedstock enables efficient CO2 reduction without the need for expensive O2 removal steps.
LEF1 enhances β-catenin transactivation through IDR-dependent liquid–liquid phase separation
Authors: Zhao Bing , Li Zhuoxin , Yu Shaoqing , Li Tingting , Wang Wen , Liu Ran , Zhang Biyu , Fang Xiya , Shen Yezhuang , Han Qiuying , Xu Xin , Wang Kai , Gong Weili , Li Tao , Li Ailing , Zhou Tao , Li Weihua , Li Teng
Published: September 2023

Wnt/β-catenin signaling plays a crucial role in cancer development, primarily activated by β-catenin forming a transcription complex with LEF/TCF in the nucleus and initiating the transcription of Wnt target genes. Here, we report that LEF1, a member of the LEF/TCF family, can form intrinsically disordered region (IDR)-dependent condensates with β-catenin both in vivo and in vitro, which is required for β-catenin-dependent transcription. Notably, LEF1 with disrupted IDR lost its promoting activity on tumor proliferation and metastasis, which can be restored by substituting with FUS IDR. Our findings provide new insight into the essential role of liquid–liquid phase separation in Wnt/β-catenin signaling and present a potential new target for cancer therapy.
Consumer Perceptions and Behaviors on Digital Payment Adoption Among Older Generation Z and Younger Millennials in Phnom Penh, Cambodia
Authors: Leang Pisey , Ramsamy Siva Shankar , Phaphuangwittayakul Aniwat , Loahavilai Piang-or
Published: September 2023

Purpose:  The study's goal is to better understand how older and younger generations in Phnom Penh, Cambodia, behave when it comes to using digital payments. Investigating the choice of mobile payment application in the Phnom Penh region is another objective of this study. Here, it is also investigated how usage, economic situation, and adoption of mobile payments are related.

 

Theoretical framework:  One of the most well-known research models on consumer behavior among younger and older generations and the adoption of new technical systems emphasizes the influence of geography, socioeconomic status, and specific traits on consumer acceptance. The concept considers factors including social effects, credibility requirements, effort expectations, and performance requirements when determining the best digital payment application.

 

Design/Methodology/Approach: The Unified Theory of Acceptance and Use of Technology (UTAUT) model and K-mean clustering for distance and economic status studies were used in this research paper to select 150 locals in Phnom Penh from the target population in order to study consumer behavioral intention to accept digital payment method and application.

 

Findings:  The result we aimed to show and analyses the Digital payment methods, payments sharing, receiving, storing evidences, that older generation started understanding the digital payment by Khmer language and accepting the digital transactions from known customers. The current generation using Sathapana application and English Language in wide ranges through the Phom Penh region. The study also trying to exhibit the purpose of the digital payment systems in and across the e-commerce activities, through the older and younger generation.

 

Research, Practical & Social implications:  The elder generation Z handled digital payments for regional transactions like banking, home tasks, loan repayment, peer lending, travel, and local marketplaces in Khmer. The subsequent generations of millennials also incorporated cross-border payments in English and Khmer.

 

Originality/Value:  Bringing up a Digital Platform shall make a positive change in economy and circulation of economy to the people and country. Unless the people trust the digital payments, they cant share their money for the business or basic operations to run the government. Thy the Digital Payment applications shall understand the behavior of the customers and share the services through the digital payment systems.
Study of Immersion in Augmented Reality Through Analysis of Immersion Elements in Museums
Authors: Zhang Xiaofan
Published: September 2023

With the advent of the information age, augmented reality technology can enhance the sense of reality in the virtual world and immerse people in the real and virtual world. People have always been interested in virtual space or augmented reality technology, especially in the face of historical development trends. Museums have always been open to the public, they are not just a collection, but also an exhibition for the public. Through analyzing different museums, it is found that museums with augmented reality technology exhibitions are non-profit museums for the purpose of emotional experience. In order to find out the immersion factors of virtual reality in museums, on the basis of previous research, this paper divides immersion in augmented reality into story immersion, five-sense experience immersion, and spatial interaction immersion. Through the analysis of different museums, it is found that immersion through five-sense experience is the most commonly used method when all display media are included. This method provides educational content for museum visitors and projects virtual presentations through monitors and portable IT devices, thereby increasing visitors’ viewing pleasure.
Território Barra da Tijuca: do sertão carioca aos condomínios fechados
Authors: De Mendonca Valeria
Published: September 2023

Parte da pesquisa Território e territorialidade: do “sertão carioca” aos condomínios fechados da Barra da Tijuca, este artigo tem como cenário dois condomínios da Zona Oeste do Rio de Janeiro – Barra Sul e Pontões da Barra –, situados lado a lado no bairro da Barra da Tijuca, Rio de Janeiro. Inicialmente, foram resgatadas as primeiras formações populacionais no território pesquisado, com intuito de aprofundarem-se as significações sociais construídas, bem como de verificarem-se as características sociais e culturais emergentes, incluindo as dinâmicas organizacionais dos sujeitos que ali habitam. Daí a ênfase no conceito de espaço como intercessório e passível de ser atravessado por outras significações, que acabam por lhe conferir diferentes ângulos e significados. A metodologia liga-se à vertente de pesquisa qualitativa e participativa, voltada às questões temáticas sobre o cotidiano social em seus desdobramentos culturais e identitários. Para isso, fez-se um mapeamento das potencialidades dos locais estudados e dos usuários que ali moram ou transitam, por meio da análise de entrevistas, como forma de incorporar a dimensão subjetiva ao território espacial, numa aproximação dos territórios vividos e construídos. Por ser um bairro planejado para preservar áreas públicas e manter um distanciamento padrão entre as construções, a Barra da Tijuca volta para a promoção de um estilo de vida que visa a um bem-estar e a uma qualidade de vida na integração Homem/Natureza. Sua geografia, com uma grande planície cercada por mar, lagoas e montanhas, favoreceu a construção de condomínios, de shoppings e de grandes vias de circulação de veículos; contudo, a maior particularidade dessa área é seu caráter de diversificação, unindo várias classes sociais que por ali moram/circulam/estudam/trabalham. Por ter sua história documentada, incluindo as povoações e a composição geográfica do início do século XVII, a área permite uma pesquisa direcionada à composição social e territorial.
Atração de produções audiovisuais e desenvolvimento do turismo cinematográfico: uma análise da Rio Film Commission e da São Paulo Film Commission
Authors: De Melo Priscila , Nathália Körössy  , Rute Gabriela dos Santos Paes  , Evenly Maria dos Santos
Published: September 2023

A atração de produções audiovisuais para uma localidade é uma forma de divulgar turisticamente o destino e de atrair visitantes por meio da promoção do turismo cinematográfico. Estudos prévios apontam para a necessidade de se criar relações de sinergia entre as OGD e atores públicos e privados dos setores turístico e audiovisual para gerar oportunidades em curto, médio e longo prazo (Polianskaia, Rãdut, & Stanciulescu, 2016). A atuação de um ator institucional em particular torna-se essencial para somar aos esforços da OGD no desenvolvimento do turismo cinematográfico: a film commission. Este artigo se debruça sobre as duas principais film commissions brasileiras – São Paulo Film Commission e Rio Film Commission – com o objetivo de analisar sua atuação na captação de produções audiovisuais e no desenvolvimento do turismo cinematográfico em cooperação com as OGD locais. Por último, faz uma reflexão sobre o modelo organizacional das film commissions a partir das contribuições teóricas de Costa (2008). Como procedimentos metodológicos, realizou pesquisas bibliográfica e documental, além de entrevistas online com gestores das duas film commissions. Aos dados coletados, foi conferida uma abordagem qualitativa por meio da análise categorial de conteúdo. Como principal achado, a partir da análise da atuação das film commissions e das relações endógenas e exógenas por elas cultivadas, concluiu-se que a Rio Film Commission apresenta um modelo organizacional do tipo integrado fechado e a SPFilm alcança o modelo ideal descrito na literatura – integrado aberto. A pesquisa empírica revelou, ainda, que as film commissions não aproveitam o potencial da atuação colaborativa com as OGD, o que corrobora com Hudson (2011) quando afirma que as film commissions tendem a ignorar o turismo cinematográfico, atuando apenas numa perspectiva mais focada de atração de produções audiovisuais, missão principal desse tipo de entidade. Por fim, esta pesquisa concluiu que o turismo cinematográfico depende de um conjunto de estratégias e ações para que esta atividade aconteça não apenas a curto prazo, mas também a médio e longo prazo; além de depender da cooperação com outros atores, sendo um deles as film commissions.
Queerness en altamar: otredad en Black Sails y Our Flag Means Death
Authors: Vizcarra García Nadia Yazmin , Pinto Barrera Diana Laura
Published: September 2023

En el presente artículo se analizan dos series televisivas: Black Sails y Our Flag Means Death, abordándolas desde la narrativa que manejan de la construcción de les Otres, lo que entenderemos como otredad. El proceso de otredad viene de una herencia colonial que establece qué identidades son relegadas. Como método de diferenciación, la otredad puede ser impuesta por los grupos dominantes, quienes se hallan en la posición de señalar a quiénes entiende como Otres. Desde esta construcción, se hace hincapié en la presencia de la colonialidad e imperialismo, y su relación con las vivencias queer de los personajes.
Translating Transitivity of Indonesian Tourism Texts and Its English Translation : A Case in Madura
Authors: Sriyono Sriyono
Published: September 2023

Abstract. This research aims at investigating the translation of the transitivity system of Madura tourism texts from Indonesian as the Source Text (ST) into English as the Target Text (TT). Besides, this also purposes to study how the transitivity as the representation of experiential meaning in tourism texts is realized and translated. The method used in this research is qualitative descriptive, while the data were taken from tourism texts of promotional media in Madura. Accordingly, Systemic Functional Linguistics (SFL) is pondered as a tool to identify the transitivity system and its translation of tourism promotion media in Madura. This study shows that the transitivity in tourism texts is translated differently which results in the realization of experiential meaning expression between ST and TT. Most of the experiential meaning in ST are realized with the relational process and as well as in the TT. Transposition and modulation in terms of translation technique also influence the differences of the understanding of readers (tourists) to the object promoted in Madura. Therefore, the process and participant in the transitivity system found ST and TT also generates the dissimilarities interpretation of experiential meaning and point of view in Indonesian tourism texts and its English translation. Keywords: transitivity; translation; tourism texts
Multimodal Feedback on speaking: Effectiveness and Students’ Perspective
Authors: Syafryadin Syafryadin , Wardhana Dian Eka Chandra
Published: September 2023

Abstract. Multimodal feedback needs to be studied and researched to enhance student’s ability. Thus, this research aims to examine the feedback which using technology and conventional without using technology in speaking, wanted to explore how multimodal feedback could influence the students’ speaking ability, know the student’s perception on multimodal feedback and the reason multimodal feedback could improve students’ speaking ability. The research used a sequential mixed method design with test and interview as instruments. The sample was 54 students for experimental and control group. The result showed that there is not significant different between multimodal feedback with using technology and without using technology. However, in terms of mean score, multimodal feedback with using technology is higher than multimodal feedback without using technology on improving students’ speaking ability. Another result showed that the students had positive response towards the use of multimodal feedback on learning speaking because it can give them much knowledge and upgrade their ability in speaking class. Keywords: Multimodal feedback; using technology; speaking ability
The Online English Extensive Reading Activities Using Google Classroom in Pandemic Covid-19
Authors: Meinawati Euis , Purwaningrum Prapti Wigati , Setianingrum Herlin Widasiwi , Alawiyah Sufi , Chodidjah Chodidjah
Published: September 2023

Abstract. The study purpose was to increase English extensive reading activities using google classroom in online learning process, especially in pandemic Covid-19 situation. This research is action research which used exploratory mixed method using Elliot model. Process of collecting data used observation, interview, diary note, and test. The technique of analysis data was reduction, presentation, and taking conclusion. The research finding show that google classroom has given significant impact on English extensive reading in the classroom. Some students think that it is easy to delivery assignment and correction of the task. They can do it out of class. It can be seen from the average score from reading test in pretest is 53 and posttest is 87. Therefore, integrating digital literacy with the reading learning is a big challenge for the learning and teaching process. Keywords: Extensive Reading, Google Classroom, Online Class, Covid-19