bluuebunny/crossref_metadata_2025 huggingface dataset:
Manipulation of dipeptidylpeptidase 10 in mouse and human in vivo and in vitro models indicates a protective role in asthma
Authors: Zhang Youming , Poobalasingam Thanushiyan , Yates Laura L. , Walker Simone A. , Taylor Martin S. , Chessum Lauren , Harrison Jackie , Tsaprouni Loukia , Adcock Ian M. , Lloyd Clare M. , Cookson William O. , Moffatt Miriam F. , Dean Charlotte H.
Published: December 2017

We previously identified dipeptidylpeptidase 10 (DPP10) on chromosome 2 as a human asthma susceptibility gene, through positional cloning. Initial association results were confirmed in many subsequent association studies but the functional role of DPP10 in asthma remains unclear. Using the MRC Harwell N-ethyl-N-nitrosourea (ENU) DNA archive, we identified a point mutation in Dpp10 that caused an amino acid change from valine to aspartic acid in the β-propeller region of the protein. Mice carrying this point mutation were recovered and a congenic line was established (Dpp10145D). Macroscopic examination and lung histology revealed no significant differences between wild-type and Dpp10145D/145D mice. However, after house dust mite (HDM) treatment, Dpp10 mutant mice showed significantly increased airway resistance in response to 100 mg/ml methacholine. Total serum IgE levels and bronchoalveolar lavage (BAL) eosinophil counts were significantly higher in homozygotes than in control mice after HDM treatment. DPP10 protein is present in airway epithelial cells and altered expression is observed in both tissue from asthmatic patients and in mice following HDM challenge. Moreover, knockdown of DPP10 in human airway epithelial cells results in altered cytokine responses. These results show that a Dpp10 point mutation leads to increased airway responsiveness following allergen challenge and provide biological evidence to support previous findings from human genetic studies.

This article has an associated First Person interview with the first author of the paper.
Naked mole rat brain mitochondria electron transport system flux and H+ leak are reduced during acute hypoxia
Authors: Pamenter Matthew E. , Lau Gigi Y. , Richards Jeffrey G. , Milsom William K.
Published: December 2017

Mitochondrial respiration and ATP production are compromised by hypoxia. Naked mole rats (NMRs) are among the most hypoxia-tolerant mammals and reduce metabolic rate in hypoxic environments; however, little is known regarding mitochondrial function during in vivo hypoxia exposure in this species. To address this knowledge gap, we asked whether the function of NMR brain mitochondria exhibits metabolic plasticity during acute hypoxia. Respirometry was utilized to assess whole-animal oxygen consumption rates and high-resolution respirometry and was utilized to assess electron transport system (ETS) function in saponin-permeabilized NMR brain. We found that NMR whole animal oxygen consumption rate reversibly decreased by ∼ 85% in acute hypoxia (4 hrs at 3% O2). Similarly, relative to untreated controls, permeabilized brain respiratory flux through the ETS was decreased by ∼ 90% in acutely hypoxic animals. Relative to FCCP-uncoupled total ETS flux, this functional decrease was observed equally across all components of the ETS except for complex IV (cytochrome c oxidase), at which flux was further reduced, supporting a regulatory role for this enzyme during acute hypoxia. The maximum enzymatic capacities of ETS complexes I-V were not altered by acute hypoxia; however, the mitochondrial H+-gradient decreased in step with the decrease in ETS respiration. Taken together, our results indicate that NMR brain ETS flux and H+ leak are reduced in a balanced and regulated fashion during acute hypoxia. Changes in NMR mitochondrial metabolic plasticity mirror whole animal metabolic responses to hypoxia.
FATORES CONDICIONANTES DA SATISFAÇÃO GERAL DOS USUÁRIOS DOS SERVIÇOS DE UMA BIBLIOTECA
Authors: Manenti Diogo Zapparoli , Bezerra George Christian Linhares
Published: December 2017

O objetivo deste artigo é analisar os condicionantes da satisfação dos usuários de uma biblioteca instalada em Instituição de Ensino Superior e testar um modelo de satisfação geral dos usuários dos serviços. Os dados obtidos a partir de um questionário aplicado junto a uma amostra composta por estudantes de uma faculdade foram analisados por meio de regressão linear múltipla. Os resultados evidenciaram que os fatores “espaço físico”, “variedade de livros” e “serviços web” estão positivamente relacionados com o nível de satisfação geral indicado pelos estudantes (enquanto usuários dos serviços). Estes resultados estão consoantes com estudos prévios e evidenciam a natureza multidimensional do construto satisfação. As implicações para os gestores referem-se à utilização desses parâmetros e condicionantes como possíveis fatores que podem ser observados na gestão da satisfação dos serviços de bibliotecas. Nesse sentido, com base nos efeitos dos diferentes condicionantes, é possível orientar os esforços de melhoria dos serviços. Parece razoável haver relevância deste artigo, pois há poucos estudos que tratam desta temática, e são raros no contexto estudado.
A PLATAFORMA METODOLÓGICA DO CUSTEIO BASEADO EM ATIVIDADE E TEMPO (TDABC) NO ÂMBITO DA PRESTAÇÃO DE SERVIÇOS DE RECICLAGEM DE PLÁSTICOS
Authors: Pereira Francisco Isidro
Published: December 2017

Há uma falsa ideia de que os modelos de gestão disponíveis são incompatíveis com estruturas empresariais de frágeis sustentação administrativa. Não obstante, qualquer que seja o ângulo de visão de funcionamento de uma empresa, ela é constituída de um conjunto de atividades, as quais são regidas por gastos. Sob esse raciocínio, a teoria disponibiliza meios de explicitar tais atividades e identificar os recursos e os gastos decorrentes. A plataforma metodológica do custeio baseado em atividades e tempo (TD-ABC), é um dos métodos mais requintado. Sob essa perspectiva, decidiu-se contrastar o modelo delineando a pergunta condutora da investigação: quão preciso é a medição dos gastos do processo de reciclagem de plástico de uma unidade empresarial. Portanto, o objetivo descortinado foi aferir a precisão da lógica do método TD-ABC na apuração dos gastos decorrente do processo de reciclagem de plástico pós-consumo. O método do case research foi o adequado, e a coleta foi baseada em entrevistas semiestruturadas e observação seletiva. A configuração do modelo se mostrou simples e de fácil entendimento, sendo possível proporcionar insights quanto às oportunidades para melhorias operacionais.
COMPROMETIMENTO ADMINISTRATIVO NA ADVANCE COMUNICAÇÃO: UM ESTUDO DA PERCEPÇÃO DOS GESTORES
Authors: Fernandes Jocilene Marques , Sá José Wilton Bessa Macedo
Published: December 2017

Este artigo apresenta um estudo sobre o comprometimento administrativo na Advance Comunicação à luz da percepção dos gestores. O objetivo deste estudo é verificar o grau de comprometimento dos gestores da Advance Comunicação e o quanto estes se identificam com a empresa. Na pesquisa realizada, questiona-se como se estabelece a relação entre o comprometimento dos gestores da Advance com a satisfação no trabalho, a qualidade de vida no trabalho e quais os reflexos no desempenho. Para concretização da pesquisa, realizou-se um estudo com abordagem quantitativa. Foi utilizado para coleta de dados uma escala (NAVARRO et al., 2008), cuja análise ocorreu em função das categorias: comprometimento, identificação com a empresa, satisfação e desempenho. Como resultado, verificou-se que há um alto nível de afinidade entre os gestores e a empresa o que revela a base afetiva do comprometimento forte nessa instituição. Além disso, os gestores atestam que quanto mais satisfeito é o trabalhador, maior é seu desempenho. Considera-se, pois, que a organização pesquisada, de um modo geral, é gerenciada por pessoas comprometidas e satisfeitas com o que fazem. Também, é possível considerar que a instituição tem investido em gestão de pessoas, caso contrário não haveria satisfação por parte dos funcionários.
TEVEP: A METODOLOGIA BRASILEIRA DE GESTÃO DE PROJETOS APLICADA EM UMA EMPRESA DE MINERAÇÃO NO PARANÁ
Authors: Kfoury Tobias , Kfoury Leticia Lamounier , Silva Júnior Ovidio Felippe Pereira da , Silva Maurício Dias da
Published: December 2017

Existe uma lacuna a ser preenchida pelos métodos de gerenciamento de projetos de forma a facilitar sua aplicabilidade. Este artigo apresenta o TEvEP como uma metodologia de gestão de projetos que consegue contornar esta lacuna, visando contribuir para o desenvolvimento dos projetos em empresas a partir da participação de todos os envolvidos de forma lúdica e simples, proporcionando uma linguagem única dentro da empresa, fazendo que a comunicação entre todos seja fortalecida e os resultados sejam mais facilmente alcançados. Foi realizada uma entrevista semiestruturada face a face com o autor da metodologia, triangulando com dados secundários. A conclusão que este artigo atinge é que, ao pensar em um projeto, é necessário visualizá-lo antes de agir; pensar antes de executar. É perceptível a facilidade com que a equipe entende o método e executa os projetos. Deve ser simples do começo ao fim, assim como propõe o TEvEP.
Burden of neurodevelopmental disorders in low and middle-income countries: A systematic review and meta-analysis
Authors: Bitta Mary , Kariuki Symon M. , Abubakar Amina , Newton Charles R.J.C
Published: December 2017

Background: Childhood mortality from infectious diseases has declined steadily in many low and middle-income (LAMIC) countries, with increased recognition of non-communicable diseases such as neurodevelopmental disorders (NDD). There is lack of data on the burden of NDD in LAMIC. Current global burden of these disorders are largely extrapolated from high-income countries. The main objective of the study was therefore to estimate the burden of NDD in LAMIC using meta-analytic techniques.

Methods: We systematically searched online databases including Medline/PubMed, PsychoInfo, and Embase for studies that reported prevalence or incidence of NDD. Pooled prevalence, heterogeneity and risk factors for prevalence were determined using meta-analytic techniques.

 Results: We identified 4,802 records, but only 51 studies met the eligibility criteria. Most studies were from Asia (52.2%) and most were on neurological disorders (63.1%). The median pooled prevalence per 1,000 for all NDD was 7.6 (95%CI 7.5-7.7), being 11.3 (11.7-12.0) for neurological disorders and 3.2 (95%CI 3.1-3.3) for mental conditions such as attention-deficit hyperactivity disorder (ADHD). The type of NDD was significantly associated with the greatest prevalence ratio in the multivariable model (PR=2.6(95%CI 0.6-11.6) (P>0.05). Incidence was only reported for epilepsy (mean of 447.7 (95%CI 415.3-481.9) per 100,000). Perinatal complications were the commonest risk factor for NDD.

Conclusion: The burden of NDD in LAMIC is considerable. Epidemiological surveys on NDD should screen all types of NDD to provide reliable estimates.
Economic Activity Rates in Asia-Pacific Countries With a High Human Development Index
Authors: Савинкина Лариса , Savinkina Larisa , Дроздова Екатерина , Drozdova Ekaterina , Перминова Г. , Perminova G.
Published: December 2017

The paper presents the results of the research revealing the economic activity of the population of Asia-Pacific countries (The Republic of Korea, Japan, the Russian Federation, and the People’s Republic of China) who have a high human development index. The data of the paper were received with the help of the methodology developed by the International Labour Organization. The authors have come to the conclusion that countries with a high human development index are characterized by the average level of the economic activity of the population (not exceeding 65%). This level allows a person or a household to have the income which is enough to provide high living standards, invest into human capital assets, and raise the human development index. Consequently, the economic activity of the population makes provisions for human development which in turn refi nes the quality and eff ectiveness of the country’s manpower.
Suppression of the dayside magnetopause surface modes
Authors: Пилипенко Вячеслав , Pilipenko Vyacheslav , Козырева Ольга , Kozyreva Olga , Бэддели Лиза , Baddeley Liza , Лорентцен Дэг , Lorentzen Dag , Белаховский Владимир , Belakhovsky Vladimir
Published: December 2017

Magnetopause surface eigenmodes were suggested as a potential source of dayside high-latitude broadband pulsations in the Pc5-6 band (frequency about 1–2 mHz). However, the search for a ground signature of these modes has not provided encouraging results. The comparison of multi-instrument data from Svalbard with the latitudinal structure of Pc5-6 pulsations, recorded by magnetometers covering near-cusp latitudes, has shown that often the latitudinal maximum of pulsation power occurs about 2–3° deeper in the magnetosphere than the dayside open-closed field line boundary (OCB). The OCB proxy was determined from SuperDARN radar data as the equatorward boundary of enhanced width of a return radio signal. The OCB-ULF correspondence is further examined by comparing the latitudinal profile of the near-noon pulsation power with the equatorward edge of the auroral red emission from the meridian scanning photometer. In most analyzed events, the “epicenter” of Pc5-6 power is at 1–2° lower latitude than the optical OCB proxy. Therefore, the dayside Pc5-6 pulsations cannot be associated with the ground image of the magnetopause surface modes or with oscillations of the last field line. A lack of ground response to these modes beneath the ionospheric projection of OCB seems puzzling. As a possible explanation, we suggest that a high variability of the outer magnetosphere near the magnetopause region may suppress the excitation efficiency. To quantify this hypothesis, we consider a driven field line resonator terminated by conjugate ionospheres with stochastic fluctuations of its eigenfrequency. A solution of this problem predicts a substantial deterioration of resonant properties of MHD resonator even under a relatively low level of back-ground fluctuations. This effect may explain why there is no ground response to magnetopause surface modes or oscillations of the last field line at the OCB latitude, but it can be seen at somewhat lower latitudes with more regular and stable magnetic and plasma structure.
Distribution of temperature coefficient density for muons in the atmosphere
Authors: Кузьменко Василий , Kuzmenko Vasiliy , Янчуковский Валерий , Yanchukovsky Valery
Published: December 2017

To date, several dozens of new muon detectors have been built. When studying cosmic-ray intensity variations with these detectors, located deep in the atmosphere, it is necessary to calculate all character-istics, including the distribution of temperature coeffi-cient density for muons in the atmosphere, taking into account their specific geometry. For this purpose, we calculate the density of temperature coefficients of muon intensity in the atmosphere at various zenith angles of detection at sea level and at various depths underground for different absorption ranges of primary protons and pions in the atmosphere.
The perceived frequency and impact of adverse events in dentistry
Authors: Wright Simon , Ucer Cemal , Speechley Stuart
Published: December 2017

What are the main factors in the aetiology of error?
The impacts of a biofuel use on the gas turbine operating performance
Authors: Febijanto Irhan
Published: December 2017

The use of Pure Plant Oil (PPO) as a fuel blend in a power plant is mandatory as stipulated in the Ministerial Decree of Energy and Mineral Resource of the Republic of Indonesia. However, the implementation of PPO used in power generation has many obstacles due to a lack of information concerning the impacts of PPO used in the operating performance of the power generation engine. In this study, the effect of PPO as a blended fuel with High-Speed Diesel (HSD) was studied by using the gas turbine with a capacity of 18 MW. The PPO was blended based on volume with a ratio of 0%, 5%, 10% and 20%. As the results, it is shown that the use of PPO with a blend ratio of 20% is the maximum fuel blend ratio according to the threshold value of a flue gas temperature and a vibration velocity in the gas turbine.
Los temas históricos conflictivos y su abordaje escolar: un ejemplo español
Authors: Valls Rafael , Parra David , Fuertes Carlos
Published: December 2017

En este estudio se analiza la forma en que los “tiempos difíciles” de la reciente historia española (la Guerra Civil y la dictadura franquista, 1936-1975) han sido tratados tanto en los manuales escolares de historia como en el interior de las aulas, estableciendo, por una parte, los avances historiográficos y didácticos conseguidos y, por otra, las actuales insuficiencias y deficiencias de tales planteamientos desde la perspectiva de un tratamiento realmente democrático y reconciliatorio de los mismos. Los avances han sido muy lentos, tanto en las representaciones sociales del conjunto de la sociedad española como en su presentación escolar. Todo ello permite afirmar que esta cuestión sigue siendo, como en numerosos otros ejemplos internacionales de uno y otro hemisferio, un asunto conflictivo, problemático y candente. No existen, posiblemente, soluciones fáciles a estos conflictos de larga duración y configuración, pero parece imprescindible que, desde la escolarización básica, tengan que ser atendidos debidamente para colaborar en la creación de una ciudadanía democrática y responsable de sus devenires.
Historia y cultura en la Licenciatura en Diseño Industrial
Authors: Montoro Claudia , Del Barco María Elena , Ramos Fabián
Published: December 2017

La enseñanza de la Historia en la Licenciatura en Diseño Industrial supone varios desafíos: uno es instalar un proceso de reflexión sobre una práctica donde predomina el perfil técnico; otro implica trabajar con alumnos ingresantes universitarios, en una carrera creada recientemente (2013) en la Facultad de Arquitectura, Diseño y Urbanismo de la Universidad Nacional del Litoral. Nuestra propuesta plantea un abordaje cultural de la historia occidental, desde la Antigüedad a la primera Modernidad, en sus múltiples dimensiones: el contexto histórico en sus aspectos políticos, sociales y económicos; el pensamiento en el campo de la forma y sus representaciones; las transformaciones materiales y técnicas; y el énfasis en la producción material, como “objeto” o “producto industrial”. Es así que se han practicado diferentes estrategias para mejorar el proceso enseñanza-aprendizaje: una de desarrollo cronológico y otra que plantea una mirada retrospectiva. Estos ensayos, implementados durante dos cuatrimestres en cada caso, permiten exponer distintos enfoques en cuanto al dictado de clases, el encuadre de los debates seminariales, el diseño de los trabajos prácticos y el modo de aproximación a las fuentes; y se constituyen en el objetivo de este artículo.
Enseñanza de la historia escolar. Un aporte al desarrollo del pensamiento crítico
Authors: Godoy Vera Fernando
Published: December 2017

El estudio es el resultado de una investigación cualitativa realizada con un grupo de profesores y profesoras que imparten clases de historia en centros de educación  secundaria de Chile,  que indaga en sus ideas sobre qué puede aportar la enseñanza de la historia al desarrollo del pensamiento crítico  de los estudiantes. La información obtenida a través de cuestionarios, entrevistas y análisis curricular evidencia que los docentes consideran el pensamiento crítico como un proceso continuo de desarrollo de habilidades intelectuales, sociales e  históricas. El profesorado también considera que el pensamiento crítico debe enseñar a los estudiantes a pensar y actuar de manera razonada y autónoma frente  a situaciones de su entorno social. El desarrollo de  habilidades intelectuales y sociales puede ser abordado desde cualquier disciplina, pero la historia escolar tiene un papel fundamental en la formación del pensamiento crítico. Los docentes son conscientes de esta realidad, pero no siempre realizan una enseñanza que forme el pensamiento histórico y ayude al alumnado a desarrollar una conciencia histórica, que es la aportación más relevante de la enseñanza de la historia a la formación del pensamiento crítico.
Analisis Banjir dan Perencanaan Desain Transportasi Sungai di Kota Bojonegoro
Authors: Prastica Rian Mantasa Salve , Maitri Caya , Nugroho Pratomo Cahyo , Hermawan Ade
Published: December 2017

One of the worst problem in Bojonegoro is flood. This research aims to know the factor that could become the factor of flood in Bojonegoro. Besides that, this research analyses the planning of transportation river design in Bojonegoro. Flood discharge analysis uses Nakayasu synthesis unit hydrograph for period of 5 years, 10 years, 25 years, 50 years, and 100 years, then they would be compared to the water maximum capacity that could be loaded by the river. According to the analysis result, Bengawan Solo River in Bojonegoro could not able to load flood discharge from Nakayasu synthesis unit hydrograph analysis for all periods. The result conclusion that captured by HEC-RAS application has the same idea. It shows flood water surface is more than full bank capacity elevation. For river transportation design planning, according to analysis of parameter of depth, width for one and two lanes, turning basin and its depth, the ship design that recommended to ship in the Bengawan Solo River in Bojonegoro are cargo ship and passenger ship with draft of 0.6 m and LOA of 18 m, or the capacity of a passenger ship is 70 people.
Zkoumání (kvality) výuky: Srovnání dvou přístupů
Authors: Najvar Petr
Published: December 2017

Tato studie kontrastivně představuje dva antagonické přístupy ke zkoumání edukačních procesů ve školní výuce. Jedním z nich je tzv. IVŠV videostudie výuky jako reprezentant kvantitativních videostudií (KVS); přístup využívající deduktivní kategoriální systémy k zachycení obsahu a formy vyučování a učení a ke kvantifi kujícímu zobecnění vztaženému např. k interakčním vzorcům ve výuce či oborovým a oborovědidaktickým specifikům výuky. Druhým z nich je obsahově zaměřený přístup ke zkoumání a zlepšování výuky jako přístup stavějící na induktivním postupu při identifi kaci obsahových jader výuky a na kvalitativním hodnocení didaktické kvality výukových situací. Tyto výzkumné přístupy jsou využity pro osvětlení rozdílů v povaze didaktického poznání generovaného postupy stavějícími na tzv. předem strukturované reflexi, ve srovnání s didaktickým poznáním, jež přináší tzv. následně strukturovaná reflexe výuky.Klíčová slova: výzkum výuky, videostudie, obsahově zaměřený přístup, analýza výukových situací, předem strukturovaná refl exe, následně strukturovaná reflexe.
Somatotype, diet and nutritional status of women
Authors: Drywień Małgorzata E. , Frąckiewicz Joanna , Górnicka Magdalena , Ważna Beata , Zielińska Paulina , Wójcik Katarzyna , Kulik Stanisław
Published: December 2017

The relationship between energy value and nutrients intake and the body shape and size parameters (weight, height, waist and hip circumferences) has become an interesting research area for nutritionists and dieticians. The aim of this study was to determine the relationship between the body shape and size parameters (weight, height, waist and hip circumferences), somatotype (according to the Rohrer (RI) index) and energy value and nutrients intake of women. The study was conducted in 2014 and 2016 on 148 female volunteers aged 57–88 from the Mazovian and Lublin province (Poland). Sample selection was targeted at elderly people with different body types. The exclusion criteria were: multi-organ failure, cancer and disability. Then among the subjects, a survey was conducted, that included demographic data, lifestyle, health status and vitamins and minerals supplements use. Food intake has been assessed using a 3-day dietary food records. The somatotype was determined using the RI with the Curtis key, classifying the subjects as ectomorphic (n=30), mesomorphic (n=31) and endomorphic (n=87). The somatotype was significantly related to place of residence, physical activity, waist and hip circumference, WHR and BMI index, total protein intake, animal protein intake, vitamin E intake (p≤0.05) and to fat, phosphorus and thiamine intake (p≤0.1). The obtained results showed that the place of residence, physical activity, chronic diseases, the use of specialized diet, body weight fluctuations, BMI and WHR were different depending on the somatotype in the examined group of women. Endomorphic subjects had significantly greater waist and hip circumference and diastolic blood pressure compared to the other somatotypes. The somatotype had only a significant effect on total protein, animal protein and vitamin E intake, and ectomorphic elderly women may be particularly susceptible to nutrient deficiencies. Due to the risk of macronutrient, vitamin and mineral deficiencies in the diets of the examined women, it seems necessary to educate this group as well as caregivers and doctors in the area of nutrition adapted to the needs of the elderly.
Measured versus self-reported body height and body mass in patients after an acute coronary syndrome
Authors: Domagała Zygmunt , Kałka Dariusz , Kurc-Darak Bożena , Womperski Krzysztof , Rusiecki Lesław , Krauz Ewa S. , Gworys Bohdan , Dąbrowski Paweł
Published: December 2017

The basic anthropometric data describing a person in the broadest context are body weight and height, two of the most frequently analyzed somatometric parameters. The same is true I in relation to clinical patients. The aim of the present study was to compare the self-reported and actual body weight, height and BMI in patients suffering from coronary artery disease and undergoing cardiac rehabilitation. The study sample consisted of 100 patients treated for coronary artery disease. The patients were asked to state their body weight and height. At the same time a three-person study team took measurements, which were later the basis for verification and objective assessment of the data provided by the patients. Statistical analysis was performed with Statistics 11.0 PL software. The analysis of mean results for the assessed group of patients has shown the presence of statistically significant differences between declared and actual data. The differences were observed for both male and female study population. It has been proven that the subjects declare greater body height (mean value 1.697 m vs. 1.666 m) and lower body weight (80.643 kg vs. 82.051 kg). Based on the data from surveys and direct measurements, the body mass index for the self-reported and actual data was calculated. A comparison of these values has shown considerable statistically significant differences. The differences between declared and actual data point to highly subjective self-assessment, which disqualifies the declared data in the context of monitoring of treatment and rehabilitation processes. The authors believe that actual data should be used in direct trial examination of patients suffering from coronary artery disease who presented with acute coronary syndrome.
Prognostic Intake of Molecular Markers in Lung Cancer The Pulmonologist Point Of View
Authors: Dantes Elena , Tofolean Doina Ecaterina , Fildan Ariadna Petronela , Mazilu Laura , Gogonea Ioana , Dumitrache-Rujinski S. , Arghir Oana Cristina
Published: December 2017

Lung cancer remains one of the most frequent pathologies in Pulmonology Departments. Tumor extension, histopathological types, and treatment influence the prognosis and survival in lung cancer. Five years survival dramatically decreases for the 4th-stage of the disease. Non-small cell lung cancer (NSCLC) represents the vast majority of lung cancers. In the last decades, important findings have been made on identifying standardized molecular biomarkers that control tumor growth in lung adenocarcinoma. The discovery of new drugs led to the increased survival, even in extensive forms of the disease. The greatest advances could be obtained by targeting EGFR genetic mutations or EML4-ALK translocate in patients diagnosed with adenocarcinoma lung cancer
Why OR.NET? Requirements and perspectives from a medical user’s, clinical operator’s and device manufacturer’s points of view
Authors: Czaplik Michael , Voigt Verena , Kenngott Hannes , Clusmann Hans , Hoffmann Rüdiger , Will Armin
Published: December 2017

In the past decades, modern medicine has been undergoing a change in the direction of digitalisation and automation. Not only the integration of new digital technologies, but also the interconnection of all components can simplify clinical processes and allow progress and development of new innovations. The integration and interconnection of medical devices with each other and with information technology (IT) systems was addressed within the framework of the Federal Ministry of Education and Research (BMBF)-funded lighthouse project OR.NET (“Secure dynamic networking in the operating room and clinic”.) (OR.net-Forschungskonsortium (OR.net Research Syndicate.) OR.net – Sichere dynamische Vernetzung in Operationssaal und Klinik [Online]. Available:www.ornet.org. [last accessed 22 March 2017]). In this project the standards and concepts for interdisciplinary networking in the operating room (OR) were developed. In this paper, the diverse advantages of the OR.NET concept are presented and explained by the OR.NET “Medical Board”. This board represents the forum of clinical users and includes clinicians and experts from various specialties. Furthermore, the opinion from the viewpoint of operators is presented. In a concluding comment of the “Operator Board”, clinical user needs are aligned with technical requirements.
POD-Galerkin reduced order methods for CFD using Finite Volume Discretisation: vortex shedding around a circular cylinder
Authors: Stabile Giovanni , Hijazi Saddam , Mola Andrea , Lorenzi Stefano , Rozza Gianluigi
Published: December 2017

Vortex shedding around circular cylinders is a well known and studied phenomenon that appears in many engineering fields. A Reduced Order Model (ROM) of the incompressible ow around a circular cylinder is presented in this work. The ROM is built performing a Galerkin projection of the governing equations onto a lower dimensional space. The reduced basis space is generated using a Proper Orthogonal Decomposition (POD) approach. In particular the focus is into (i) the correct reproduction of the pres- sure field, that in case of the vortex shedding phenomenon, is of primary importance for the calculation of the drag and lift coefficients; (ii) the projection of the Governing equations (momentum equation and Poisson equation for pressure) performed onto different reduced basis space for velocity and pressure, respectively; (iii) all the relevant modifications necessary to adapt standard finite element POD-Galerkin methods to a finite volume framework. The accuracy of the reduced order model is assessed against full order results.
Building Ecological Networks In Slovakia And Poland
Authors: Izakovičová Zita , Świąder Małgorzata
Published: December 2017

The paper is aimed at evaluating the creation of territorial systems of ecological stability in two neighbouring countries - Slovakia and Poland. The paper evaluates various initiatives and approaches and their positives and negatives. It represents methodical approaches to the creation of territorial systems of ecological stability as well as the legal provision of ecological networks in both countries. The outcome of the evaluation is the proposal for the necessary measures to improve the situation.
Phylogenetic Diversity of Plant Metacommunity of the Dnieper River Arena Terrace Within the ‘Dnieper-Orilskiy ’ Nature Reserve
Authors: Zhukov Olexander , Kunah Olga , Dubinina Yulia , Ganga Dmitry , Zadorozhnaya Galina
Published: December 2017

This article presents the features of the phylogenetic organization of the plant communities of the Dnieper River terrace within the ‘Dnieper-Orilskiy’ Nature Reserve and the patterns of its spatial variation involving remote sensing data of the Earth’s surface. The research materials were collected in the period 2012−2016 from within the nature reserve. The research polygon is within the first terrace (arena) of the Dnieper valley. Sandy steppe, meadow, forest and marsh communities within the Protoch river floodplain and the Orlova ravine, as well as artificial pine plantations were the habitats present within the research polygon. The vegetation description was carried out on 10×10 m (100 m2) plots. A total of 94 geobotanical descriptions were made. Data on plant phylogeny was obtained by the Phylomatic service. Phylogenetic diversity of the communities was assessed by the Faith, Simpson and Shannon indices. Phylogenetic analysis was performed by means of a double principal coordinate analysis (DPCoA). The vegetation cover within the investigated polygon was represented by 189 species. Abundance Phylogenetic Deviation (APD) for the investigated metacommunity was evaluated to −0.53, which is statistically significantly different from random alternatives (p = 0.001). The APD negative value indicates that phylogenetic organization of the investigated metacommunity is overdispersed. The permutation procedure allowed us to establish that the eigenvalues of the DPCoA-axes obtained as a result of the real phylogenetic tree were significantly higher than their own number for the random phylogenetic trees for the first seven axes. This indicates that the first seven axes are useful for additional information on the ordination structure of the metacommunity.
Criteria for the Selection of Tourism Destinations by Students from Different Countries
Authors: Dębski Maciej , Nasierowski Wojciech
Published: December 2017

The objective of this paper is to identify selected aspects of the management of information about prospective tourist destinations by young people (students) from Canada, Poland, and Trinidad and Tobago. On the basis of a questionnaire study, the ranking of preferences of respondents (i.e., the main criteria of destination choice) has been presented. Students were selected as respondents - as a “convenient sample” - in this privately funded study. A variety of aspects related to comfort (and convenience) and attractiveness have been identified as most important to the choice of destination. These are also leading motives that may form a platform for advertising campaigns and suggestions for regional development. This examination has been done mainly with the use of analysis of averages, Spearman correlation coefficients, and various approaches to factor analysis. It turns out that despite very different characteristics of respondents from the three countries, both their preferences and motives for promotion of the destination are very similar. Conclusions can be helpful for travel agencies and those responsible for the development of tourism infrastructure, as well as for the organization of further studies on the subject. The combination of various statistical tools used when examining the subject and the finding - that is, the similarity of preferences between travelers - can be regarded as new value when examining the subject.
Seeking Optimal Nutrition for Healthy Body Mass Reduction Among Former Athletes
Authors: Maciejewska Dominika , Michalczyk Małgorzata , Czerwińska-Rogowska Maja , Banaszczak Marcin , Ryterska Karina , Jakubczyk Karolina , Piotrwski Jakub , Hołowko Joanna , Drozd Arleta , Wysokińki Paweł , Ficek Krzysztof , Wilk Krzysztof , Lubkowska Anna , Cięszczyk Paweł , Bertrand Jerzy , Stachowska Ewa
Published: December 2017

The aim of the study was to investigate the efficacy of 6 week Mediterranean diet or 30% calorie restriction on the fatty acid profile and eicosanoids (hydroxyoctadecadienoi acids and hydroxyeicosatetraenoic acids) concentration. Furthermore, basic biochemical variables such as insulin, glucose, HOMA-IR, and a lipid profile were estimated. The study enrolled 94 Caucasian former athletes aged 20-42, with body height of 179 ± 16.00 cm and body mass of 89.26 ± 13.25 kg who had not been active for at least 5 years. The subjects were randomly assigned to one of the three intervention groups: CR group – the 30% calorie restriction (n = 32), MD group - the Mediterranean diet (n = 34), and C group - a control group (n = 28). The pattern of nutrition was analysed before and after the experiment using the 72 h food diaries. In order to evaluate the effect of diet intervention, the following variables were measured: anthropometrics, basic biochemical variables (insulin, fasting glucose, HOMA-IR, lipid profile), fatty acids and their blood derivatives profiles. The CR group showed significantly lower levels of several biochemical variables, i.e., BMI, total cholesterol LDL, TG, total lipids, insulin and HOMA – IR (p < 0.05). Subjects consuming the MD diet significantly decreased their BMI and reduced the level of total lipids (p < 0.05). We did not find any significant changes in the C group. The analysis of the fatty acid profile revealed that the CR group had a significantly decreased EPA level (p < 0.05). The MD group showed a significantly increased level of the DHA (p < 0.05) and improvement in the omega - 3 index (p < 0.05). Subjects following the MD also showed significantly lower concentrations of 15 - hydroxyicosatetraenoic acid (15-HETE). We did not observe any significant differences between the CR and C groups. Within short time, calorie restriction helps to improve lipid variables and insulin resistance. The MD diet seems to be more advantageous in the decrease of inflammation, but does not improve basic biochemical variables. We can conclude that calorie restriction can be a good choice for former athletes, although EPA and DHA supplementation is needed.
Reliability and Usefulness of the 30-15 Intermittent Fitness Test in Male and Female Professional Futsal Players
Authors: Valladares-Rodríguez Santiago , Rey Ezequiel , Mecías-Calvo Marcos , Barcala-Furelos Roberto , Bores-Cerezal Antonio J.
Published: December 2017

The purpose of this study was to determine the reliability and usefulness of the 30-15 Intermittent Fitness Test (30-15IFT) in professional male and female futsal players. Thirteen male (24.4 ± 5.6 years; 174.5 ± 10.3 cm; 70.3 ± 9.9 kg) and fourteen female (23.3 ± 4.5 years; 165.8 ± 6.2 cm; 61.7 ± 5.5 kg) professional futsal players performed the 30-15IFT on two occasions, separated by 5 days. Maximal intermittent running velocity (VIFT) and heart rate at exhaustion (HRpeak) data were collected for both tests. Reliability was assessed by the intraclass correlation coefficient (ICC), typical error (TE) expressed as a coefficient of variation (CV), and smallest worthwhile change (SWC). VIFT demonstrated very good reliability between sessions, both for male (ICC = 0.92) and female (ICC = 0.96) players. As the TE for VIFT and HRpeak was similar to the calculated SWC for both male and female players, the usefulness of the test was rated as “medium”. A change in performance of at least 2 stages in male players, or a change of more than 1 stage in female players could be interpreted as a meaningful change in aerobic futsal fitness. The results of this study demonstrate that the 30-15IFT is both a reliable and useful test for male and female professional futsal players.
Using Bilateral Functional and Anthropometric Tests to Define Symmetry in Cross-Country Skiers
Authors: Björklund Glenn , Alricsson Marie , Svantesson Ulla
Published: December 2017

The aim of this study was to evaluate the symmetry of anthropometry and muscle function in cross-country skiers and their association to vertical jumping power. Twenty cross-country skiers were recruited (21.7 ± 3.8 yrs, 180.6 ± 7.6 cm, 73.2 ± 7.6 kg). Anthropometric data was obtained using an iDXA scan. VO2maxwas determined using the diagonal stride technique on a ski treadmill. Bilateral functional tests for the upper and lower body were the handgrip and standing heel-rise tests. Vertical jump height and power were assessed with a counter movement jump. Percent asymmetry was calculated using a symmetry index and four absolute symmetry index levels. At a group level the upper body was more asymmetrical with regard to lean muscle mass (p = 0.022, d = 0.17) and functional strength (p = 0.019, d = 0.51) than the lower body. At an individual level the expected frequencies for absolute symmetry level indexes showed the largest deviation from zero for the heel-rise test (χ2 = 16.97, p = 0.001), while the leg lean mass deviated the least (χ2 = 0.42, p = 0.517). No relationships were observed between absolute symmetry level indexes of the lower body and counter movement jump performance (p > 0.05). As a group the skiers display a more asymmetrical upper body than lower body regarding muscle mass and strength. Interestingly at the individual level, despite symmetrical lean leg muscle mass the heel-rise test showed the largest asymmetry. This finding indicates a mismatch in muscle function for the lower body.
Relationships between Mechanical Variables in the Traditional and Close-Grip Bench Press
Authors: Lockie Robert G. , Callaghan Samuel J. , Moreno Matthew R. , Risso Fabrice G. , Liu Tricia M. , Stage Alyssa A. , Birmingham-Babauta Samantha A. , Stokes John J. , Giuliano Dominic V. , Lazar Adrina , Davis DeShaun L. , Orjalo Ashley J.
Published: December 2017

The study aim was to determine relationships between mechanical variables in the one-repetition maximum (1RM) traditional bench press (TBP) and close-grip bench press (CGBP). Twenty resistance-trained men completed a TBP and CGBP 1RM. The TBP was performed with the preferred grip; the CGBP with a grip width of 95% biacromial distance. A linear position transducer measured: lift distance and duration; work; and peak and mean power, velocity, and force. Paired samples t-tests (p < 0.05) compared the 1RM and mechanical variables for the TBP and CGBP; effect sizes (d) were also calculated. Pearson’s correlations (r; p < 0.05) computed relationships between the TBP and CGBP. 1RM, lift duration, and mean force were greater in the TBP (d = 0.30-3.20). Peak power and velocity was greater for the CGBP (d = 0.50-1.29). The 1RM TBP correlated with CGBP 1RM, power, and force (r = 0.685-0.982). TBP work correlated with CGBP 1RM, lift distance, power, force, and work (r = 0.542-0.931). TBP power correlated with CGBP 1RM, power, force, velocity, and work (r = 0.484-0.704). TBP peak and mean force related to CGBP 1RM, power, and force (r = 0.596-0.980). Due to relationships between the load, work, power, and force for the TBP and CGBP, the CGBP could provide similar strength adaptations to the TBP with long-term use. The velocity profile for the CGBP was different to that of the TBP. The CGBP could be used specifically to improve high-velocity, upper-body pushing movements.
Performance Changes of Elite Paralympic Judo Athletes During a Paralympic Games Cycle: A Case Study with the Brazilian National Team
Authors: Loturco Irineu , Pereira Lucas A. , Winckler Ciro , Bragança Jaime R. , da Fonseca Roger A. , Kobal Ronaldo , Cal Abad Cesar C. , Kitamura Katia , Nakamura Fabio Y. , Franchini Emerson
Published: December 2017

The aim of this study was to describe the variations in power performance of elite Paralympic judo athletes across three consecutive training cycles of preparation for the ParaPan American Games, the World Championship and the Paralympic Games. Eleven Paralympic judokas from the Brazilian National team participated in this study. They were repeatedly assessed using squat and countermovement jumps, mean propulsive power (MPP) in the jump-squat (JS), the bench press and prone bench pull at several moments of the preparation. Training supervision based on the optimum power zone (range of loads where power production is maximized) was provided in the final cycle, prior to the Paralympic Games. Magnitude-based inference was used to compare the repeated measurements of power performance. Lower and upper limb muscle power gradually increased throughout the cycles; however, the best results in all exercises were observed prior to the Paralympic Games, during which the team won four silver medals. As an illustration, prior to participation in the Paralympic Games the MPP in the JS was likely to very likely higher than prior to the World Championship (effect size [ES] = 0.77) and ParaPan American Games (ES = 0.53), and in January and March 2016 (ES = 0.98 and 0.92, respectively; months preceding the Paralympic Games). Power performance assessments can provide information about the evolution of Paralympic judokas, and training at the optimum power zone seems to constitute an effective method to improve lower and upper limb power in these athletes.
Trend Analysis of the Educational Choice of University Entrants as Tool to Improve the Quality of Educational Service
Authors: Mikhno Nadiya , Sorokina Liudmila
Published: December 2017

In the conditions of development of modern Ukrainian society the questions related to educational space are extraordinarily actual. It is education that gives an opportunity for development and progress of personality and the quality of education in modern terms determines the competitiveness of university and national system of education on the whole. Mirroring the European experience of quality management of education a sociological estimation and examination of functioning of University teaching has gained importance with the aim of preventing off-grade services and general verification of accordance of educational services to the demand of consumers, state and society. Coming from it, it is becoming urgent to develop methodologies and measures to make complex sociological estimation of activity of university with the aim of upgrading educational services.
Influence of fluorine substituents on the properties of phenylboronic compounds
Authors: Gozdalik Jan T. , Adamczyk-Woźniak Agnieszka , Sporzyński Andrzej
Published: December 2017

Rapid development of research on the chemistry of boronic acids is connected with their applications in organic synthesis, analytical chemistry, materials’ chemistry, biology and medicine. In many applications Lewis acidity of boron atoms plays an important role. Special group of arylboronic acids are fluoro-substituted compounds, in which the electron withdrawing character of fluorine atoms influences their properties. The present paper deals with fluoro-substituted boronic acids and their derivatives: esters, benzoxaboroles and boroxines. Properties of these compounds, i.e. acidity, hydrolytic stability, structures in crystals and in solution as well as spectroscopic properties are discussed. In the next part examples of important applications are given.
Intertemporal Decision Making After Brain Injury: Amount-Dependent Steeper Discounting after Frontal Cortex Damage
Authors: Białaszek Wojciech , Swebodziński Bartłomiej , Ostaszewski Paweł
Published: December 2017

Traumatic brain injuries to the frontal lobes are associated with many maladaptive forms of behavior. We investigated the association between brain damage and impulsivity, as measured by the rate of delay discounting (i.e., the extent to which future outcomes are devalued in time). The main aim of this study was to test the hypothesis of steeper discounting of different amounts in a group of patients with frontal lobe damage. We used a delay discounting task in the form of a structured interview. A total of 117 participants were divided into five groups: three neurological groups and two groups without brain damage. Our analyses showed that patients with focal damage to the frontal lobes demonstrated steeper delay discounting than other participants. Other clinical groups demonstrated similar discounting rates. The data pattern related to the magnitude effect on the group level suggested that the magnitude effect is absent in the group of patients with damage to the frontal lobes; however, results were less consistent on an individual level. Amount-dependent discounting was observed in only two groups, the healthy control group and the neurological group with other cortical areas damaged.