bluuebunny/crossref_metadata_2025 huggingface dataset:
Wastewater surveillance of SARS-CoV-2 in Austria: development, implementation, and operation of the Tyrolean wastewater monitoring program
Authors: Daleiden Beatrice , Niederstätter Harald , Steinlechner Martin , Wildt Stefan , Kaiser Manfred , Lass-Flörl Cornelia , Posch Wilfried , Fuchs Stefan , Pfeifer Bernhard , Huber Andreas , Oberacher Herbert
Published: January 2022

Wastewater-based epidemiology (WBE) is an effective approach for tracking information on spatial distribution and temporal trends of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) at the community level. Herein, the development, implementation, and operation of the wastewater monitoring program serving Tyrol – a federal province of Austria – are described. The development of this program was initiated by Tyrolean health authorities at the end of the first phase of the Coronavirus disease 2019 (COVID-19) pandemic (May 2020). In close co-operation with the water sector and academic institutions, efficient and effective workflows and processes for wastewater surveillance were established. The monitoring program went into operation in November 2020. By the end of July 2021, a total of 5,270 wastewater influent samples collected at 43 sites were analyzed. The monitoring program provided valuable insights into the development of the pandemic situation in Tyrol and fulfilled several tasks that are of importance in different phases of the pandemic. It represented an early-warning system, provided independent confirmation of temporal trends in COVID-19 prevalence, enabled the assessment of the effectiveness of measures, alerted about bursts of disease activity, and provided evidence for the absence of COVID-19. These findings underline the importance of establishing national wastewater monitoring programs as a complementary source of information for efficient and effective pandemic management.
Identification of a Four Cancer Stem Cell-Related Gene Signature and Establishment
of a Prognostic Nomogram Predicting Overall Survival of
Pancreatic Adenocarcinoma
Authors: Li Shuanghua , Chen Rui , Luo Wang , Lin Jinyu , Chen Yunlong , Wang Zhuangxiong , Lin Wenjun , Li Baihong , Wang Junfeng , Yang Jian
Published: January 2022

Background:

Cancer stem cells (CSCs) are now being considered as the initial component
in the development of pancreatic adenocarcinoma (PAAD). Our aim was to develop a CSCrelated
signature to assess the prognosis of PAAD patients for the optimization of treatment.

Materials and Methods:

Differentially expressed genes (DEGs) between pancreatic tumor and
normal tissue in the Cancer Genome Atlas (TCGA) were screened out, and the weighted gene correlation
network analysis (WGCNA) was employed to identify the CSC-related gene sets. Then,
univariate, Lasso Cox regression analyses and multivariate Cox regression were applied to construct
a prognostic signature using the CSC-related genes. Its prognostic performance was validated
in TCGA and ICGC cohorts. Furthermore, Univariate and multivariate Cox regression analyses
were used to identify independent prognostic factors in PAAD, and a prognostic nomogram was
established.

Results:

The Kaplan-Meier analysis, ROC curve and C-index indicated the good performance of
the CSC-related signature at predicting overall survival (OS). Univariate Cox regression and multivariate
Cox regression revealed that the CSC-related signature was an independent prognostic
factor in PAAD. The nomogram was superior to the risk model and AJCC stage in predicting OS.
In terms of mutation and tumor immunity, patients in the high-risk group had higher tumor mutation
burden (TMB) scores than patients in the low-risk group, and the immune score and the ESTIMATE
score were significantly lower in the high-risk group. Moreover, according to the results
of principal component analysis (PCA) and Gene Set Enrichment Analysis (GSEA), the low-risk
and high-risk groups displayed different stemness statuses based on the risk model.

Conclusion:

Our study identified four CSC-related gene signatures and established a prognostic
nomogram that reliably predicts OS in PAAD. The findings may support new ideas for screening
therapeutic targets to inhibit stem characteristics and the development of PAAD.
Natural Bridged Bicyclic Peptide Macrobiomolecules from Celosia argentea and Amanita phalloides
Authors: Dahiya Rajiv , Dahiya Sunita , Fuloria Neeraj Kumar , Mourya Rita , Dahiya Saurabh , Fuloria Shivkanya , Kumar Suresh , Shrivastava Jyoti , Saharan Renu , Chennupati Suresh V. , Patel Jayvadan K.
Published: January 2022

Bridged peptide macrobicycles (BPMs) from natural resources belong to types of compounds that are not investigated fully in terms of their formation, pharmacological potential, and stereo- chemical properties. This division of biologically active congeners with multiple circular rings has merits over other varieties of peptide molecules. BPMs form one of the most hopeful grounds for the establishment of drugs because of their close resemblance and biocompatibility with proteins, and these bio-actives are debated as feasible, realistic tools in diverse biomedical applications. Despite huge potential, poor metabolic stability and cell permeability limit the therapeutic success of macrocyclic peptides. In this review, we have comprehensively explored major bicyclic peptides sourced from plants and mushrooms, including βs-leucyl-tryptophano-histidine bridged and tryptophanocysteine bridged peptide macrobicycles. The unique structural features, structure-activity relationship, synthetic routes, bioproperties, and therapeutic potential of the natural BPMs are also discussed.
Computational and Experimental Investigations of 7-(4-nitrophenyl)benzo [6,7]chromeno[3,2-e]pyrido[1,2-a]pyrimidin-6(7h)-one
Authors: Rai Sonam , Bishnoi Abha , Devi Poornima , Afza Nishat
Published: January 2022

Acstract:

In-silico studies are used for the prediction of the properties of several novel materials using the computer simulation technique. The present study describes the complete description of the molecular vibrations and electronic features of the title compound by this technique. 7-(4-nitrophenyl)benzo[6, 7]chromeno[3,2-e]pyrido[1,2-a]pyrimidin-6(7H)-one was prepared by the multicomponent reaction of 2H-pyrido[1,2-a]pyrimidine-2,4(3H)-dione, 2-naphthol and p-nitrobenzaldehyde. The structure of the compound was confirmed by UV, IR, NMR (1H, 13C), and mass spectroscopic studies. The compound was further subjected to quantum chemical calculations at the level of Hartree-Fock (HF) method using Lan2DZ basis set to compute polarizability, hyperpolarizabilities, AIM approach, Natural bond orbital analysis, complete vibrational assignments, Mulliken charges, spectral analysis and HOMO-LUMO energies.
WITHDRAWN: Flavone as a Potential Therapeutic Agent: A Review
Authors: Dhunmati K  , Manimegalai V
Published: January 2022

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Data Analysis and Mapping of Research Interest in Clinical Trials of
Tuberculosis by Text Mining Platform of Artificial Intelligence using
Open-Source Tool Orange Canvas
Authors: Patel Swayamprakash , Patel Ashish , Shah Umang , Patel Mehul , Solanki Nilay , Patel Mruduka , Patel Suchita
Published: January 2022

Background:

Reading every clinical trial for any disease is tedious, as is determining the
current progress, especially when the number of clinical trials is huge. The Text Mining Platform of
Artificial Intelligence (AI) can help to simplify the task.

Methods:

A large pool of tuberculosis clinical trials has been searched through the International Clinical
Trial Registry Platform (ICTRP) and used as a textual dataset. The exported dataset of 1635 clinical
studies, in a comma-separated format, is preprocessed for data analysis and text mining. Data preparation,
corpus generation, text preprocessing, and finally, cluster analysis were carried out using the textmining
widget of the open-source machine learning tool. The hierarchical cluster analysis was used for
mapping research interests in tuberculosis clinical trials.

Result and Conclusion:

The data mining of the exported dataset of tuberculosis clinical trials uncovered interesting
facts in terms of numbers. Text mining presented a total of 41 hierarchical clusters that were further
mapped in twenty-five (25) different research interests among tuberculosis clinical trials. A novel
technique for the rapid and practical review of major clinical trials is demonstrated. As an open-source
and GUI-based tool is used for work, any researcher with working knowledge of text mining may also
use this technique for other clinical trials.
A survey on issues in cloud forensics with an experiment on time consumption
Authors:   Department of Computing, Rajarata University of SriLanka, Anuradhapura, Sri Lanka, Hettige K. H. A. , Fernando M. S. D. ,   Department of Computer Science and Engineering, University of Moratuwa, Moratuwa, Sri Lanka
Published: January 2022

Forensic investigations on cloud platforms are an oft-discussed topic in current digital forensics. Significant growth in cloud platforms is expected in the coming decade. With such growth, cloud forensic investigations may require substantial changes in their approach. The paper surveys the most mentioned issues in cloud forensic literature. It is followed by a description of some of our current work aimed at solving those issues. The first issue that we tried to analyze was the issue of the trustworthiness of the evidence. We identified that the trustworthiness of the Cloud Service Providers is hardly discussed in the literature. Based on previous publications on similar issues on standalone computers, we provided an algorithm as an initial answer to the issue. The algorithm checks for the integrity of the evidence which will be affected in a tampering attempt. The next issue that we considered was time-taken for analysis (time complexity of forensic tools). While the issue has been indicated many times in the literature, we did not find many detailed experiments conducted with tools to observe the processing time over data source size. Therefore, the paper includes the results of an experiment that was performed using an Autopsy forensic tool to measure the time complexity of its operation with a number of source files with increasing sizes. Results indicated that the analyzing times usually increased with the size of the source file and that it might become unmanageable with increasing sizes.
Encouraging Behavior Changes and Preventing Cardiovascular Diseases Using the Prevent Connect Mobile Health App: Conception and Evaluation of App Quality
Authors: Agher Dahbia , Sedki Karima , Despres Sylvie , Albinet Jean-Pierre , Jaulent Marie-Christine , Tsopra Rosy
Published: January 2022

Background

Cardiovascular diseases are a major cause of death worldwide. Mobile health apps could help in preventing cardiovascular diseases by improving modifiable risk factors such as eating habits, physical activity levels, and alcohol or tobacco consumption.

Objective

The aim of this study was to design a mobile health app, Prevent Connect, and to assess its quality for (1) assessing patient behavior for 4 cardiovascular risk factors (unhealthy eating, sedentary lifestyle, alcohol, and tobacco consumption) and (2) suggesting personalized recommendations and mobile health interventions for risky behaviors.

Methods

The knowledge base of the app is based on French national recommendations for healthy eating, physical activity, and limiting alcohol and tobacco consumption. It contains a list of patient behaviors and related personalized recommendations and digital health interventions. The interface was designed according to usability principles. Its quality was assessed by a panel of 52 users in a 5-step process: completion of the demographic form, visualization of a short presentation of the app, testing of the app, completion of the user version of the Mobile App Rating Scale (uMARS), and an open group discussion.

Results

This app assesses patient behaviors through specific questionnaires about 4 risk factors (unhealthy eating, sedentary lifestyle, alcohol, and tobacco consumption) and suggests personalized recommendations and digital health interventions for improving behavior. The app was deemed to be of good quality, with a mean uMARS quality score of 4 on a 5-point Likert scale. The functionality and information content of the app were particularly appreciated, with a mean uMARS score above 4. Almost all the study participants appreciated the navigation system and found the app easy to use. More than three-quarters of the study participants found the app content relevant, concise, and comprehensive. The aesthetics and the engagement of the app were also appreciated (uMARS score, 3.7). Overall, 80% (42/52) of the study participants declared that the app helped them to become aware of the importance of addressing health behavior, and 65% (34/52) said that the app helped motivate them to change lifestyle habits.

Conclusions

The app assessed the risky behaviors of the patients and delivered personalized recommendations and digital health interventions for multiple risk factors. The quality of the app was considered to be good, but the impact of the app on behavior changes is yet to be demonstrated and will be assessed in further studies.
Biomedical Research and Informatics Living Laboratory for Innovative Advances of New Technologies in Community Mobility Rehabilitation: Protocol for Evaluation and Rehabilitation of Mobility Across Continuums of Care (Preprint)
Authors: Ahmed Sara , Archambault Philippe , Auger Claudine , Durand Audrey , Fung Joyce , Kehayia Eva , Lamontagne Anouk , Majnemer Annette , Nadeau Sylvie , Pineau Joelle , Ptito Alain , Swaine Bonnie
Published: January 2022

BACKGROUND

Rapid advances in technologies over the past 10 years have enabled large-scale biomedical and psychosocial rehabilitation research to improve the function and social integration of persons with physical impairments across the lifespan. The Biomedical Research and Informatics Living Laboratory for Innovative Advances of New Technologies (BRILLIANT) in community mobility rehabilitation aims to generate evidence-based research to improve rehabilitation for individuals with acquired brain injury (ABI).

OBJECTIVE

This study aims to (1) identify the factors limiting or enhancing mobility in real-world community environments (public spaces, including the mall, home, and outdoors) and understand their complex interplay in individuals of all ages with ABI and (2) customize community environment mobility training by identifying, on a continuous basis, the specific rehabilitation strategies and interventions that patient subgroups benefit from most. Here, we present the research and technology plan for the BRILLIANT initiative.

METHODS

A cohort of individuals, adults and children, with ABI (N=1500) will be recruited. Patients will be recruited from the acute care and rehabilitation partner centers within 4 health regions (living labs) and followed throughout the continuum of rehabilitation. Participants will also be recruited from the community. Biomedical, clinician-reported, patient-reported, and brain imaging data will be collected. Theme 1 will implement and evaluate the feasibility of collecting data across BRILLIANT living labs and conduct predictive analyses and artificial intelligence (AI) to identify mobility subgroups. Theme 2 will implement, evaluate, and identify community mobility interventions that optimize outcomes for mobility subgroups of patients with ABI.

RESULTS

The biomedical infrastructure and equipment have been established across the living labs, and development of the clinician- and patient-reported outcome digital solutions is underway. Recruitment is expected to begin in May 2022.

CONCLUSIONS

The program will develop and deploy a comprehensive clinical and community-based mobility-monitoring system to evaluate the factors that result in poor mobility, and develop personalized mobility interventions that are optimized for specific patient subgroups. Technology solutions will be designed to support clinicians and patients to deliver cost-effective care and the right intervention to the right person at the right time to optimize long-term functional potential and meaningful participation in the community.

INTERNATIONAL REGISTERED REPORT

PRR1-10.2196/12506
The Humanities in Public: A Computational Analysis of US National and Campus Newspapers
Authors: Thomas Lindsay , Droge Abigail
Published: January 2022

Academic defenses of the humanities often make two assumptions: first, that the overwhelming public perception of the humanities is one of crisis, and second, that our understanding of what the humanities mean is best traced through a lineage of famous reference points, from Matthew Arnold to the Harvard Redbook. We challenge these assumptions by reconsidering the humanities from the perspective of a corpus of over 147,000 relatively recent national and campus newspaper articles. Building from the work of the WhatEvery1Says project (WE1S), we employ computational methods to analyze how the humanities resonate in the daily language of communities, campuses, and cities across the US. We compare humanities discourse to science discourse, exploring the distinct ways that each type of discourse communicates research, situates itself institutionally, and discusses its value. Doing so shifts our understanding of both terms in the phrase “public humanities.” We turn from the sweeping and singular conception of “the public” often invoked by calls for a more public humanities to the multiple overlapping publics instantiated through the journalistic discourse we examine. And “the humanities” becomes not only the concept named by articles explicitly “about” the humanities, but also the accreted meaning of wide-ranging mentions of the term in building names, job titles, and announcements. We argue that such seemingly inconsequential uses of the term index diffuse yet vital connections between individuals, communities, and institutions including, but not limited to, colleges and universities. Ultimately, we aim to show that a robust understanding of how humanities discourse already interacts with and conceives of the publics it addresses should play a crucial role in informing ongoing and future public humanities efforts.
MERN: A Full-Stack Development
Authors: Baiskar Yogesh
Published: January 2022

Abstract: In this modern world, we all are attracted to learning various technologies. So in this paper, we work and find out such top technology which used in the corporate world. So you will be familiar with the flow of these modern web technologies. Keywords: Back-End, Database, Digital Marketing, Domain and Hosting, Front-End, Full-Stack Development, Git and Github, Google Analytics, Heroku, Linux, MERN stack, Netlify, VPS, etc.
Comparative Analysis of Patients Visiting Department of Korean Internal Medicine in a Korean Medicine Hospital Before and During COVID-19 - From July 2018 to June 2021 at Wonkwang University Jeonju Korean Medicine Hospital -
Authors: Lee Ji-eun , Shin Yong-jeen , Shin Sun-ho
Published: January 2022

Objectives: This study aimed to analyze the healthcare utilization behavior of patients visiting the department of Korean internal medicine in the Korean medicine hospital of Wonkwang University in Jeon-ju from July 2018 to June 2021.Methods: We retrospectively analyzed the medical records of 26,108 patients and sorted the data by period, month, visiting types, new or returning types, sex, and age group. IBM SPSS 26.0 and the R 4.05 ‘changepoint' package were used with various statistical methods, such as Independent t-test, Mann-Whitney test, Chi-square test, Simple regression analysis. The P-value was set at 0.05.Results and Conclusions: Females outnumbered males regardless of period, and the ratio of females fell after COVID-19. Regardless of visiting types, patients in their 50s, 60s, and 70s outrated any other age group. The average number of females among the returning patients decreased significantly after COVID-19, but did not in males. Outpatients under 10 and in their 10s decreased significantly after COVID-19, as did inpatients in their 40s and 60s. The average duration of hospitalization was extended significantly after COVID-19. The number of outpatients and inpatients decreased as time passed after COVID-19. We expect that the results of this study will be used as reference materials in analyzing the effects of COVID-19 on healthcare utilization.
THE OUTCOMES OF A MCKENZIE-BASED APPROACH COMBINED WITH OTHER INTERVENTIONS FOR A PATIENT WITH LOW BACK PAIN AND PIVD
Authors: Naqvi Waqar
Published: January 2022

Low backache is the most common health condition among adults which leads to pain and disability. Radiculopathy is a impaired condition that causes low back pain that radiates to the lower extremity. The aim of this case study is to establish a comprehensive physical therapy plan for a patient who has chronic low back pain and PIVD. The patient was a 30-year-old female with a one month history of LBP. The pain further radiated to both legs. Further magnetic resonance imaging (MRI) was done, which indicated PIVD at the level ofL4-L5The patient's main concern about her condition was that she was unable to work, engage in her once-loved hobbies, and function without pain or discomfort, and pain has disrupted her sleep. After eight weeks the pain level on the Numerical Pain Rating Scale had reduced from 7/10 at worst to 2/10. The patient said that aggravating pain is reduced. Capacity to function has been restored and sleeping has also been improved. A detailed physical therapy program that included a patient with chronic low back pain and PIVD are McKenzie extension exercise, therapeutic exercise, electrical stimulation, individualized patient education, manual techniques, superficial heat and home exercise program.
COMPARATIVE EVALUATION OF SUBCUTICULAR SKIN CLOSURE USING MONOCRYL (POLIGLECAPRONE 25) VERSUS ETHILON (MONOFILAMENT POLYAMIDE BLACK)
Authors: Gandhi Jenit P
Published: January 2022

Skin suturing is most important aspect of surgery in this era of minimal surgery with patient wanting minimal scar of incised wound for cosmesis. Skin not only acts as protection but also as homeostasis therefore its proper closure is important to maintain its function. Various methods of skin closure are available like subcuticular suture, adhesive tapes, staplers, etc. Subcuticular suturing is one of the skin closuring technique involving stich placement in subcuticular tissue using various suture with minimal scarring. To compare outcome of MONOCRYL (poliglecaprone 25) versus Ethilon (Monofilament Polyamide Black) suture in Subcuticular technique of skin closure. This study was conducted at Dhiraj Hospital, Smt. B.K. Shah Medical Institute and Research Centre, Suman deep Vidyapeeth Deemed to Be University (An Institution), Pipariya, Vadodara. And included total of 50 patients who were randomly divided in two groups A & B. Results were tabulated and analyzed statically to arrive at conclusion. Most of the patient belonged to 21-40 years. Female predominance was found in our study with 29 Female and 21 males. Wound Dehiscence occurred in 1 patient in Group A. 7 patients complained of Itching in Group A. Ethilon (Monofilament Polyamide Black) suture gives better result compared to MONOCRYL (poliglecaprone 25) in subcuticular wound closure.
EVALUATION OF NEPHROPROTECTIVE AND ANTIOXIDANT POTENTIAL OF CUCUMIS PUBESCENS IN RATS
Authors: Kumar Harish
Published: January 2022

To find the effective way of treatment of diabetic nephropathy with herbal medicine with modern allopathic medicines. In the present research study we use streptozotocin model (55mg/kg) for inducing the diabetes and development and progression of Diabetic may leads to various diabetic complication; Nephropathy is one of the imperative complication leads to renal physiological alteration. Various nephropathy evaluation parameters were assessed in this research study by various methods. Cucumis pubescencs an herb used for the treatment of the nephropathy along with the Antidiabetic drugs. The result obtained in the current research study showed that combination of herbal and modern allopathic medicine in experimentally induced diabetic nephropathy in rats were significantly aid in nephropathic complications. At present therapeutic scenario there are a lot of allopathic medicines in the market for the treatment of diabetes mellitus, but due to severe complication with the drugs therapy move towards the ayurvedic/Herbal treatment. At present some advance research is needed to explore the active phytoconstituents for the treatment of various ailments.
Corporate social responsibility performance, reporting and generalized methods of moments (GMM): A structured review of corporate governance determinants and firms financial consequences
Authors: Velte Patrick
Published: January 2022

In line with the business case argument for corporate social responsibility (CSR), CSR performance and reporting should lead to positive firms’ financial outputs. As CSR issues may be linked with greenwashing behavior and self-impression management, effective corporate governance as a monitoring tool should increase CSR reporting and performance. While empirical-quantitative research on CSR extremely increased since the last decade, endogeneity concerns impair the validity of research results. This paper focuses on one of the most important techniques to include endogeneity concerns: the generalized method of moments (GMM) as dynamic panel regression. This paper summarizes the results of archival research on corporate governance determinants and firms’ financial consequences of CSR performance and reporting. The increased importance of managing and reporting on CSR issues represents the key motivation to conduct a systematic literature review. By including 131 quantitative peer-reviewed empirical studies in this field, in line with legitimacy and stakeholder theory, there are indications that 1) gender diversity positively influences CSR performance, and 2) CSR performance increases both accounting- and market-based financial performance (ROA and Tobin’s Q). A research agenda with detailed research recommendations are provided for future studies
Validación de un Modelo de Medición de Responsabilidad Social. Un Estudio Multivariado Transeccional del Sector- Bananero
Authors: Saltos-Cruz Juan Gabriel , Zavala-Calahorrano Alicia Marifernanda , León-Saltos Amparito Cecilia , Villalba-Orozco Adriana Katherine
Published: January 2022

Introducción. Esta investigación constituye el resultado de una revisión bibliográfica y una validación estadística multivariante. En esta se plantean las aristas de medición del estado actual de responsabilidad social. Objetivo. Diseñar un instrumento de diagnóstico de la gestión de responsabilidad social para el sector agrícola. El instrumento de diagnóstico de la responsabilidad social se estableció en referencia a la ISO 26000 en el sector bananero de la provincia de Los Ríos, República del Ecuador. Materiales y métodos. El presente estudio fue de tipo no experimental. El método teórico utilizado fue el inductivo-deductivo a partir del análisis de cinco modelos de responsabilidad social. El método empírico ejecutado fue de recolección de información con un instrumento estructurado por escalas de Likert de 5 opciones. El procedimiento estadístico empleado en la medición de la calidad instrumental estuvo conformado por análisis de fiabilidad y análisis factorial. Resultados. Los indicadores de fiabilidad evidencian un Alfa de Cronbach de 0,754 y un Alfa de Cronbach de dos mitades de 0,852 y 0,783. Los indicadores del análisis factorial muestran un KMO de 0,788, Prueba de esfericidad de Bartlett con un CHI-cuadrado de 1644,521, grados de libertad de 210 y una significancia estadística de 0,000; Una varianza total explicada de 7 grupos con una varianza acumulada del 80,76 %. Conclusión. El constructo en estudio y las siete aristas en cuestión poseen un alto grado de fiabilidad y validez. Además, el instrumento es apto para su aplicación en las empresas del sector bananero.
Use of high-energy ionizing radiation for microbiological decontamination of coastal soil in the Kolubara river basin, Serbia
Authors: Gajic Vuk , Vujcic Ivica , Drazic Gordana , Milovanovic Jelena , Masic Slobodan
Published: January 2022

The Kolubara river pollutes the coastal land in the river basin and makes it
unsuitable for agricultural activities in that area. Also, contaminated
land poses a risk to the environment. Different methods can be used for
soil decontamination. These methods include biological treatment/bioremediation, chemical oxidation, soil stabilization, physical
methods, such as soil leaching, or treatment with high-energy ionizing
radiation. Gamma irradiation of soil is a well-known method of inhibiting
microbial activity. This paper investigated the influence of different doses
and dose rates of gamma irradiation on microorganisms' decontamination of
coastal soil, in the Kolubara river basin. The irradiation effects on
reducing the total number of microorganisms and removing mold and pathogenic
bacteria from soil samples were examined. Gamma radiation affects the
soil's organic matter, causing the formation of free reactive radicals,
which act as reducing and oxidizing agents, cleaving C-C bonds, and
depolymerizing carbohydrates. It was found that a dose of 3 kGy of gamma
radiation, neutralizes all pathogenic bacteria, a dose of 5 kGy
deactivates mold in soil samples, and a dose of 10 kGy is optimal to kill
all microorganisms in the samples and sterilize exposed soil. The research
showed that the dose rate does not significantly affect microbiological
decontamination of soil using gamma irradiation. The content of heavy metals
in soil was determined, and the obtained values were compared with the
remediation limit values prescribed by the regulations. It was concluded
that the content of heavy metals in the analyzed soil samples is below the
limit of remediation values. The only exception is the slightly increased
copper content in one sample. The result of this research is the conclusion
that the coastal land from the Kolubara basin can be decontaminated by gamma
radiation treatment. This advanced soil treatment technology is available in
Serbia because there is an industrial plant for gamma radiation treatment
within the Vinca Institute.
Estimation of radiological impact on residents due to household storage of coal used for heating in Serbia
Authors: Drasler Marko , Celikovic Igor , Kandic Aleksandar , Pantelic Gordana , Milanovic Tamara , Samolov Aleksandra , Loncar Boris
Published: January 2022

This paper aims to estimate a potential radiological risk from different
kinds of coals used for domestic heating in Serbia, by measuring the
activity concentration of radionuclides and radon exhalation rate. The
obtained radon mass exhalation rate ranges from (5.3 ? 3.1)
mBqkg?1s?1 to (70.3 ? 9.4) mBqkg ?1s?1 and was highest for lignite type of
coal. It is estimated that coal stored in the basement could contribute up
to 50 Bqm?3 of indoor radon concentration at the ground level. Activity
concentrations of 226Ra, 232Th, 40K, 238U, 235U, and 210Pb in analysed coal
samples agree with previously reported concentrations of coal used in
Serbia. The values of radium equivalent concentration and external hazard
index indicate that the used coal does not represent a significant radiation
hazard.
Cardiovascular Effects of Incretin-Based Therapies: Integrating Mechanisms With Cardiovascular Outcome Trials
Authors: Ussher John R. , Greenwell Amanda A. , Nguyen My-Anh , Mulvihill Erin E.
Published: January 2022

As the worldwide prevalence of diabetes and obesity continues to rise, so does the risk of debilitating cardiovascular complications. Given the significant association between diabetes and cardiovascular risk, the actions of glucose-lowering therapies within the cardiovascular system must be clearly defined. Incretin hormones, including GLP-1 (glucagon-like peptide 1) and GIP (glucose-dependent insulinotropic polypeptide), are gut hormones secreted in response to nutrient intake that maintain glycemic control by regulating insulin and glucagon release. GLP-1 receptor agonists (GLP-1Ras) and dipeptidyl peptidase 4 inhibitors (DPP-4is) represent two drug classes used for the treatment of type 2 diabetes mellitus (T2DM) that improve glucose regulation through stimulating the actions of gut-derived incretin hormones or inhibiting their degradation, respectively. Despite both classes acting to potentiate the incretin response, the potential cardioprotective benefits afforded by GLP-1Ras have not been recapitulated in cardiovascular outcome trials (CVOTs) evaluating DPP-4is. This review provides insights through discussion of clinical and preclinical studies to illuminate the physiological mechanisms that may underlie and reconcile observations from GLP-1Ra and DPP-4i CVOTs. Furthermore, critical knowledge gaps and areas for further investigation will be emphasized to guide future studies and, ultimately, facilitate improved clinical management of cardiovascular disease in T2DM.
Early Trajectory of Estimated Glomerular Filtration Rate and Long-term Advanced Kidney and Cardiovascular Complications in Type 1 Diabetes
Authors: Perkins Bruce A. , Bebu Ionut , Gao Xiaoyu , Karger Amy B. , Hirsch Irl B. , Karanchi Harsha , Molitch Mark E. , Zinman Bernard , Lachin John M. , Boer Ian H. de
Published: January 2022

Background:
Rapid loss of estimated Glomerular Filtration
Rate (eGFR) within its normal range has been proposed as a strong predictor of
future kidney disease. We investigated this association of eGFR slope early in
the course of type 1 diabetes with long-term incidence of kidney and
cardiovascular complications.

Methods: Annual percent change in eGFR (slope) was
calculated during the Diabetes Control and Complications Trial (DCCT) for each
of 1441 participants over a mean of 6.5 years and dichotomized by presence or
absence of Early Rapid eGFR Loss (slope ≤-3% per year) as the exposure of
interest. Outcomes were incident reduced eGFR (eGFR<60ml/min/1.73m2),
composite cardiovascular events, or major adverse cardiovascular events (MACE)
during the subsequent 24-years post-DCCT closeout follow-up.

Results: At DCCT closeout (the baseline for this analysis), diabetes
duration was 12±4.8 years, most participants (85.9%) had normoalbuminuria, mean eGFR was 117.0±13.4 ml/min/1.73m2, and 149 (10.4%) had experienced Early
Rapid eGFR Loss over the preceding trial phase.
Over 24-year subsequent follow-up there were 187 reduced eGFR (6.3 per 1000
person-years) and 113 MACE (3.6 per 1000 person-years) events. Early Rapid eGFR Loss was associated with risk of reduced eGFR (HR
1.81;95% CI 1.18-2.79, p=0.0064), but not after adjustment for baseline eGFR
level (HR 0.94;95%
CI 0.53-1.66, p=0.84). There was no
association with composite cardiovascular events or MACE.

Conclusions:
In people with type 1 diabetes primarily with normal eGFR and normoalbuminuria, the preceding slope of eGFR confers
no additional association with kidney or cardiovascular outcomes beyond
knowledge of an individual’s current level.
Advanced Glycation End Products Predict Loss of Renal Function and High-Risk Chronic Kidney Disease in Type 2 Diabetes
Authors: Koska Juraj , Gerstein Hertzel C. , Beisswenger Paul J. , Reaven Peter D.
Published: January 2022

Objective:
To evaluate the association of a multicomponent advanced glycation
endproducts (AGEs) panel with decline in kidney function and its utility in predicting
renal function loss (RFL) when added to routine clinical measures in type 2
diabetes.

Research
Design and Methods: Carboxymethyl
and carboxyethyl lysine, and methylglyoxal, 3-deoxyglucosone and glyoxal
hydroimidazolones were measured in baseline serum and plasma samples,
respectively, from the Action to Control Cardiovascular Risk in Diabetes
(ACCORD, n=1,150) and the Veterans Affairs Diabetes Trial (VADT, n=447)
participants. A composite AGE-score was
calculated from individual AGE z-scores.
The primary outcome was a sustained 30% decline in eGFR (30% RFL, both
cohorts). Secondary outcomes (in ACCORD) were 40% RFL, macroalbuminuria, and
high-risk chronic kidney disease (hrCKD).

Results: After adjustment for baseline and
follow-up HbA1c and other risk factors in ACCORD, the AGE score was
associated with reduction in eGFR (beta-estimate -0.66 ml/min∙1.73m2 per year, p=0.001), a
30% RFL (hazard ratio 1.42 [95%CI: 1.13-1.78], p=0.003), a 40% RFL (1.40
[1.13-1.74], p=0.003), macroalbuminuria (1.53 [1.13-2.06], p=0.006), and hrCKD
(1.88 [1.37-2.57), p<0.0001). AGE-score
improved net-reclassification (NRI) and relative integrated discrimination
(IDI) for 30% RFL (NRI 23%, p=0.02 and relative IDI 7%, p=0.009). In VADT, the AGE-score calculated by the
ACCORD-derived coefficients was associated with 30% RFL (1.37 [1.03-1.82), p=0.03)
and improved NRI (24%, p=0.03) but not IDI (p=0.18).

Conclusions: These data provide
further support for a causal role of AGEs in diabetic nephropathy independently
of glycemic control and suggest utility of the composite AGE panel in
predicting long-term decline in renal function.
Meropenem-induced reduction in colistin susceptibility in Pseudomonas aeruginosa strain ATCC 27853
Authors: Savinova TA , Bocharova YA , Chaplin AV , Korostin DO , Shamina OV , Mayanskiy NA , Chebotar IV
Published: January 2022

Antibiotic-resistant strains of Pseudomonas aeruginosa are a global threat to public health. The knowledge of mechanisms underlying antibiotic resistance is essential to counter P. aeruginosa infections. This study describes the phenomenon of meropenem-induced cross-resistance to colistin in the ATCC 27853 strain of P. aeruginosa. The study was conducted in the specimens of P. aeruginosa grown from the reference ATCC 27853 strain in the medium containing meropenem gradients. Susceptibility of the isolates to carbapenems and colistin was assessed using the agar dilution method; susceptibly to colistin was assessed using the broth microdilution method. A total of 93 P. Aeruginosa isolates were analyzed; of them two demonstrated reduced susceptibility to carbapenems (meropenem, imipenem) and colistin. Whole-genome sequencing of the isolates was performed on a MGISEQ-2000 platform. Missense mutations in the oprD and mexD genes and a nonsense mutation in the phoQ gene were detected. We conclude that exposure of P. aeruginosa to meropenem can lead to cross-resistance to colistin, a last resort drug for P. aeruginosa infections.
Formation and development of the knowledge capital management system
Authors: FILIN Sergei A. , YAKUSHEV Aleksei Zh.
Published: January 2022

Subject. This article discusses the issues of management of creation and commercialization of intellectual capital and knowledge capital.
Objectives. The article aims to develop recommendations for optimizing the processes of creation and commercialization of intellectual capital and knowledge capital.
Methods. For the study, we used the methods of logical and comparative analyses.
Results. The article offers recommendations for optimizing the processes of creation and commercialization of intellectual capital.
Conclusions. The use of the intellectual capital and knowledge capital management system helps assure an uninterrupted implementation of innovative projects and undesirable deviation adjustment.
Twórczość Jarosławy Pulinowicz jako przykład dramaturgii zaangażowanej
Authors:   Uniwersytet Śląski, CHARKO-KLEKOT PAULINA
Published: January 2022

The article presents the description of the work of Yaroslava Pulinovich, the representative of the young generation of contemporary Russian dramaturgy. The plays of the Russian playwright are interpreted in the context of the involvement of drama and theatre in social issues. Using the concept of political quality of art of Jacques Rancière, according to which art aims to discuss social problems, the author of the article attempts to show that the work of Pulinovich falls into the definition of engaged art that involves full participation in the social life and involves the artist and the viewer in the problems of the surrounding reality. The research material that has been used is the majority of the playwright’s works, both her wellknown works such as Natasha’s dream, Zhanna or Eliza’s Land, as well as lesser-known works (Chemistry teacher, He’s gone without a word and other).
Nazwy roślin w zbiorach Michała Fedorowskiego i Elizy Orzeszkowej
Authors:   Uniwersytet Gdański, SZCZEŚNIAK KRYSTYNA
Published: January 2022

The paper deals with the response of Michał Fedorowski to Rostafinski’s questionnaire, published at the end of the 19th century. The text (published in the journal „Etnobiologia Polska” by Graniszewska, Leśniewska, Mankiewicz-Malinowska and Galera) includes all the answers provided by Fedorowski (supplemented with scientific names of plant parts – only those that were present in the attached herbarium), as well as a photograph of his signature (his name had previously been spelt as Federowski in scientific publications). The material in the collection is of extreme interest to linguists who investigate plant names of Lithuanian Rus’. The collection covers similar areas which Eliza Orzeszkowa investigated and described in Ludzie i kwiaty nad Niemnem [People and Flowers on the Neman River]. In this paper, I suggest a comparison of the plant names used in both collections, which complement each other. I also draw attention to additional aspects of the use of plants described by Fedorowski and the data which may be employed to describe features of the Polish language used at that time.
Anti-corrosive coatings for pipelines of the oil collection system
Authors:   South Kazakhstan State University, Shymkent, Kazakhstan, Yessentayeva A.A. , Nifontov U.A. ,   St. Petersburg State Marine Technical University, St. Petersburg, Russia, Nadirov K.S. ,   South Kazakhstan State University, Shymkent, Kazakhstan
Published: January 2022

The issues of obtaining new materials based on domestic raw materials, in particular, on the basis of polymer compositions with fillers, mixing in a melt in a laboratory multifunctional twin-screw extruder UR-TC with modular screws and a modular cylinder are considered.
Evaluation of the effectiveness of the use of monitoring systems for ship power plants
Authors:   GUMRF them. Admiral S.O. Makarova, St. Petersburg, Russia, Igonin V.V. , Zhukov V.A. ,   GUMRF them. Admiral S.O. Makarova, St. Petersburg, Russia
Published: January 2022

The article points out the need for the introduction of automated monitoring systems for marine power plants and provides an overview of the problems that need to be taken into account when evaluating the effectiveness of monitoring systems.
The control algorithm of the system of protection of power plants
Authors:   LLC “Progress”, St. Petersburg, Russia, Gulyy V.A. , Semenov U.M. ,   Kaluga Turbine Works, Kaluga, Russia, Serbin I.S. ,   Kaluga Turbine Works, Kaluga, Russia
Published: January 2022

A solution to the problem of improving the reliability of protection systems of production equipment is proposed, due to the fact that when checking the protection system according to the proposed algorithm without disabling the production equipment, for example, a steam turbine, the entire protection channel is covered by the check, including the final executive body of the protection system, for example, the turbine stop valve.
Оценка эффективности использования систем мониторинга судовых энергетических установок
Authors:   Admiral Makarov State University of Maritime and Inland Shipping, St. Petersburg, Russia, Igonin V.V. , Zhukov V.A. ,   Admiral Makarov State University of Maritime and Inland Shipping, St. Petersburg, Russia
Published: January 2022

The article points out the need for the introduction of automated monitoring systems for marine power plants and provides an overview of the problems that need to be taken into account when evaluating the effectiveness of monitoring systems.
Assessment of environmental indicators of automobile engines converted to gas fuel
Authors:   Ural Federal University, Yekaterinburg, Russia, Plotnikov L.V. , Osipov L.E. ,   Ural Federal University, Yekaterinburg, Russia, Plotnikov O.A ,   Ural Federal University, Yekaterinburg, Russia
Published: January 2022

The article describes the technical characteristics for two gasoline engines that are converted to methane fuel. The study was carried out on the basis of mathematical modeling in the Diesel-RК program. It is shown that the conversion of gasoline engines to methane leads to a power reduction in the range of 7.5% with a decrease in specific fuel consumption to 12%, as well as a reduction in NOx emissions by 2–3 times. It is revealed that an increase in the compression ratio to 15 leads to an increase in the power and environmental friendliness of the gas piston engine.
The Domination of Divorce by Litigation Cases; Factors and Implications (a Case Study of Parepare Religious Court Class IB)
Authors: Arafah M. , Gassing Qadir , HL Rahmatiah , Hrp Nasruddin Khalil
Published: January 2022

Divorce is a phenomenon of family division involving husband and wife with an increasing percentage in Indonesia. The increase in divorce cases in court is due to the insistence on divorce by litigation and divorce by talaq as the main initiative of husband and wife at the Parepare Religious Court. In order to discuss these issues, the data was collected using a field research (qualitative descriptive) system, so that the results showed that divorce cases from 2019-2020 showed that divorce by litigation was more dominant than divorce by talaq at the Parepare Religious Courts Class 1B. The presentation of the increasing number of divorces by litigation indicated that the wives were dissatisfied with the duties and obligations of their husbands in their marital life. Meanwhile, the factors that influenced divorce by litigation at the Parepare Religious Court consisted of 13 factors, namely third parties, drunkenness, mandates, gambling, leaving one party, imprisoned, polygamy, Domestic Violence (DV), disability, disputes or quarrels continuously, forced marriage, apostasy, and economics. In reality, economic problems, leaving one party and disputes or quarrels continuously were the highest causes in the 2019-2020 timeframe. As a result, divorce cases affected the children's psychology and the disharmony of each party