bluuebunny/crossref_metadata_2025 huggingface dataset:
The outcome of cataract surgery in eyes with end–stage glaucoma
Authors: Gračner Tomaž , Pahor Dušica
Published: February 2023

Purpose: To evaluate the outcome of phacoemulsification and intraocular lens implantation (PHACO IOL) in eyes with end–stage glaucoma.

Methods: Eighteen eyes of 18 patients with end–stage glaucoma in which PHACO IOL was performed were included in this prospective clinical study. Intraocular pressure (IOP) was measured before and 1 week, and 1, 3, 6, and 12 months after PHACO IOL. The best corrected visual acuity (BCVA), the number of antiglaucoma medications and the visual field (VF) test results before PHACO IOL and at the end of follow–up were evaluated.

Results: The follow–up period after PHACO IOL was 12 months for all eyes. The mean IOP before surgery was 13.5 mmHg (SD 2.6). There were no differences between the mean IOP measurements before and after surgery during the entire follow– up period (P>0.05). The mean preoperative BCVA was 0.65 (SD 0.3) logMAR, improving to a mean of 0.19 (SD 0.1) logMAR postoperatively (P<0.0001). The mean number of antiglaucoma medications before surgery was 1.8 (SD 1.4), and it was 2.0 (SD 1.3) postoperatively (P=0.104). The mean value of the mean deviation in 7 eyes on automated perimetry was –23.57 dB (SD 3.9) preoperatively and –22.87 dB (SD 4.1) postoperatively (P=0.105). The mean VF island in 11 eyes on Goldmann perimetry was 17.0° (SD 7.2) preoperatively, improving to 20.4° (SD 9.0) postoperatively (P=0.033).

Conclusion: PHACO IOL in eyes with end–stage glaucoma resulted in a stable IOP and a significantly improved BCVA without worsening of the VF.
Detection of vkorc1 polymorphism: comparison of polymerase chain reaction/restriction fragment length polymorphism (pcr + rflp) with allele–specific polymerase chain reaction
Authors: Stangler Herodež Špela , Stankovič Nastja , Zagradišnik Boris , Erjavec Škerget Alenka , Kokalj Vokač Nadja
Published: February 2023

Purpose: The VKORC1 polymorphism is an important genetic factor affecting warfarin dose requirement. Patients require different warfarin doses in order to achieve the target therapeutic anticoagulation. The aim of our study was to determine the frequency of single nucleotide polymorphisms (SNP) in the VKORC1 gene in the general population, using a simple, rapid, and economical method.

Methods: For genotyping, the restriction fragment length polymorphism (RFLP) of polymerase chain reaction (PCR)–amplified DNA was used and compared to allele– specific polymerase chain reaction. We genotyped 441 DNA samples obtained from the healthy general population in North–Eastern Slovenia. Genotypes for the tested group were evaluated to determine whether the population followed the Hardy–Weinberg equilibrium. The genotypes and allele frequencies were calculated.

Results: The results obtained using the allele–specific polymerase chain reaction were consistent with those obtained using the PCR + RFLP method. The G allele frequency (0.62) was higher than the A allele frequency (0.38) in the general population from North–Eastern Slovenia.

Conclusions: The PCR+RFLP method involved additional manipulation of the PCR products at the expense of analysis time, consumption of reagents and equipment. The allele–specific polymerase chain reaction was a simple and rapid method for the detection of SNP in the VKORC1 gene, and is available in any laboratory with the minimum of equipment and reagents required.
Ocena potencjału terenów poprzemysłowych w Ozorkowie – kontekst rewitalizacji
Authors: Grzelak Anna , Pielesiak Iwona
Published: February 2023

W artykule przedstawiono założenia i wyniki oceny terenów poprzemysłowych Ozorkowa – małego miasta leżącego w województwie łódzkim. Analizą objęto 12 obszarów w kontekście ich endogenicznego potencjału do wdrażania działań rewitalizacyjnych. Większość z omawianych terenów to korzystnie zlokalizowane pozostałości po XIX-wiecznym przemyśle lekkim. W ich współczesnej strukturze kluczową rolę odgrywają usługi, powrót do funkcji produkcyjnej i magazynowej, a także mieszkalnictwo. Znaczna ich część pozostaje jednak niezagospodarowana. Wyzwaniem jest także skomplikowana sytuacja własnościowa. Największym potencjałem cechują się niewielkie, centralnie położone tereny związane z XIX-wiecznym przemysłem lekkim. Najniżej oceniono z kolei predyspozycje najbardziej rozległych, peryferyjnie zlokalizowanych terenów po socjalistycznych zakładach włókienniczych i odzieżowych.
Development of three endocrinopathies under nivolumab therapy
Authors: Glibka Anastasia A. , Mazurina Natalya V. , Gridnev Danila I. , Sarantseva Ksenia A. , Troshina Ekaterina A.
Published: February 2023

Active implementation of immune checkpoint inhibitors into oncology practice leads to an increase in numbers of observed immune-mediated adverse events, including various endocrinopathies. The focus is on multiple endocrine gland involvement because their predictors are unclear.
The paper describes a clinical case of a patient with central cancer of the right lung, who had been administered immune therapy with anti-PD-1 monoclonal antibody (nivolumab). Under this treatment, three endocrine immune-mediated adverse events developed without any concomitant problems from other organs and body systems. The most interesting was the occurrence of adrenal insufficiency and fulminant diabetes mellitus, while, unlike hypothyroidism, which also developed in this patient, those two have been significantly less often described and up to now their incidence, prevalence and association with a certain subgroup of immune checkpoint inhibitors have not been identified. Despite multiple endocrine organ involvement and taking into account positive effects of the anti-tumor treatment, as well as titration of the corresponding hormonal replacement therapy, treatment with nivolumab was continued.
Patients treated with immune checkpoint inhibitors require a multidisciplinary team approach including an endocrinologist, because of the potential multiple endocrinopathies, including life-threatening.
The results of systemic thrombolytic therapy for acute ischemic stroke in women and men depending on the stroke risk factors
Authors: Kotov Sergey V. , Belkina Svetlana N. , Isakova Elena V. , Kotov Alexey S.
Published: February 2023

Background: Systemic thrombolytic therapy (STLT) with alteplase is the method of choice in all patients with acute ischemic stroke (IS) within the first 4.5 hours after the symptom onset. There is a noticeable difference between men and women in the clinical characteristics and results of stroke treatment; however, results of studies have been contradictory.
Aim: To evaluate the efficacy of STLT with alteplase in women compared to men, depending on the presence of some risk factors for stroke.
Materials and methods: This open-label prospective observational non-interventional cohort study of STLT in IS included 209 patients (102 women, the main group, and 107 men, or the comparison group) aged 32 to 86 years. All patients received STLT with alteplase within 4.5 hours from the onset of IS symptoms. The primary endpoint of the study was 28-day survival, and the secondary endpoint was the achievement of mobility independence (0 to 2 points by the modified Rankin Scale (mRS)).
Results: The demographic and clinical patient characteristics of both groups were comparable, but women were on average 5 years older than men (p = 0.003). The index IS was not the first one in 31.4% of women and 23.4% of men (p 0.05). There were no significant differences in the severity of stroke and the timing of STLT. Men had a high mortality rate in the acute period of IS, but the difference was non-significant. PST-STLT hemorrhagic transformation was more common in men, with the difference being non-significant (2 0.743, p = 0.389). Women were more likely to have type 2 diabetes mellitus (DM2) (37.3% and 20.6%, respectively, 2 7.111, p = 0.008). In women, there was a trend towards better symptom regression by about 1 point (p = 0.129). The women with DM2 had a 13% higher survival than men (p = 0.038). The numbers of patients achieving independence (02 points on the mRS scale) by Day 28 was not different (56 women and 52 men). No between-groups differences were found in the numbers of patients with arterial hypertension and atrial fibrillation. Only 13 women (12.75%) and 21 men (20%) had a normal body mass index, while 56.3% of women and 46.7% of men had obesity 2 or 3 grades, with the gender differences being non-significant.
Conclusion: In women, who have received STLT in the acute period of IS, the death rates and the functional outcomes were non-inferior to those in men, despite their older age, hyperglycemia in the acute period and past history of DM2. The risk factors for stroke in women, compared to men, could be the potential cause of more frequent IS recurrence (every third case in women and every fourth in men was recurrent). Despite a number of negative factors (age, obesity, metabolic syndrome, hyperglycemia, DM2, atrial fibrillation), there was a trend towards better outcomes of STLT in women.
Chronic glomerulonephritis and pregnancy: predictors of preterm birth
Authors: Gubina Darya V. , Prokopenko Elena I. , Nikol'skaya Irina G.
Published: February 2023

Background: Chronic kidney disease (CKD) in pregnant women, with one of its most important causes being chronic glomerulonephritis (CGN), increases the incidence of adverse perinatal outcomes and gestational complications, including preterm birth (PB). Being the main cause of infant morbidity and mortality, PB has serious medical and social significance.
Aim: To identify clinical predictors and develop a predictive model of PB in pregnant women with CGN.
Materials and methods: A retrospective/prospective study included 122 CGN patients, whose 128 pregnancies resulted in childbirth from January 2009 to November 2022. Eighty-eight pregnancies were in the patients with CKD stage 1, 15 in stage 2, 21 in stage 3a, 3 in stage 3b, and one in stage 4. One hundred and nine (109) patients (115 pregnancies) delivered on term (at least 37 weeks of gestation) and were included into the group of term deliveries, whereas 13 women with 13 pregnancies had PB within the range of 22 weeks to 36 weeks 6 days. In the patients of both groups, we assessed nephrological and obstetric history, proteinuria and arterial hypertension at baseline and during pregnancy, complications of the index pregnancy, such as preeclampsia (PE) and severe PE, anemia, urinary tract infections, acute kidney injury, placental insufficiency, and cervical insufficiency. Binary logistic regression was used for prediction modeling of PB in women with CGN.
Results: The proportion of PB in total cohort of the CGN patients was 10.2%. PB was spontaneous only in 2/13 (15.4%) cases, while in the rest of 11 pregnancies (84.6%) the delivery was induced due to maternal and fetal indications. Six independent predictors of PB were identified: body mass index, CKD stage, history of non-developing pregnancies, proteinuria during pregnancy 1 g/day, PE and placental insufficiency. The predictive model had sensitivity of 76.9%, specificity 99.1%, diagnostic efficiency 96.9%, positive predictive value 90.9%, and negative predictive value 97.4%.
Conclusion: Predicting PB and targeting modifiable factors associated with PB may improve pregnancy outcomes in patients with CGN.
“No, pero si yo quisiera lo podría hacer”: los recursos de concesividad con función atenuante en actos argumentativos en el corpus PRESEEA de Santiago de Chile
Authors: Ibarra Herrera Daniela , Guerrero González Silvana , Gajardo Moller Consuelo , González Riffo Javier
Published: February 2023

En esta investigación se estudian los recursos de concesividad con función atenuante en actos argumentativos en el corpus PRESEEA de Santiago de Chile. A partir del análisis de los datos provenientes de 36 entrevistas semidirigidas, se da cuenta del funcionamiento de los movimientos concesivos-opositivos y de las partículas discursivas concesivas en actos argumentativos, y se describe su variación sociolingüística en relación con los factores sexo, edad y nivel de instrucción de los hablantes. Los principales resultados del estudio indican que, en el castellano chileno, existen al menos 12 estrategias que cumplen una función concesiva de atenuación, entre las que destacan “sí, pero + negación”, “aunque”, “no, pero + afirmación” y “a pesar (de) que”. Estas estrategias se vinculan con las funciones de autoprotección y prevención de imagen en el desarrollo del acto argumentativo. Asimismo, se observa que la variación está dada principalmente por el factor edad de los sujetos.
"El patio de los vientos perdidos" de Roberto Burgos Cantor: aspectos de la novela del encanto de la interioridad
Authors: Orduz Rodríguez Frank Alexander
Published: February 2023

Este artículo estudia El patio de los vientos perdidos (1984), primera novela del escritor colombiano Roberto Burgos Cantor. Desde de los parámetros de La novela del encanto de la interioridad, categoría planteada por Hélène Pouliquen (2018), se muestra cómo los instantes de plenitud se oponen a un escepticismo radical. Así, se examina cómo en la novela operan paradigmas que organizan una ética de la interioridad, en donde los personajes experimentan instantes de plenitud a pesar de sus difíciles realidades.
Strategi Pengembangan Kampung Wisata Tanoker Ledokombo Melalui Pendekatan Community Based Tourism
Authors: Nugraha Cahyadi Setya , Zein Emelia , Ma'ruf Muhammad Naufal , Romadona Wulida Putri , Wulandari Leny
Published: February 2023

Kampung Wisata Tanoker Ledokombo merupakan tempat wisata berbasis komunitas yang menyajikan aktivitas budaya, pendidikan, dan kuliner tradisional. Adanya bencana pandemi menyebabkan kegiatan wisata yang terdapat di Kampung Wisata Tanoker harus dibatasi kegiatanya sehingga berdampak pada penurunan aktivitas wisata dan wisatawan. Strategi penembangan Kampung Wisata Tanoker diperlukan sebegai solusi dasar dalam mempertahankan kegiatan wisata. Metode dalam menentukan strategi pengembangan dilakukan dengan analisis SWOT dan IFAS EFAS. Melalui pendekatan Community Based Tousirm streategi pengembangan Kampung Wisata Tanoker berupa pembuatan sistem kerja sama antara pemerintah, swasta dan masyarakat selaku pemilik, pengelola, pengontrol kegiatan wisata. Strategi pengembangan mikro yang dihasilkan berupa pengembangan area festival untuk mengakomodir berbagai kegiatan wisata yang ada.
Pengembangan Kawasan Wisata Alam Berbasis Partisipasi Masyarakat (Studi Kasus Air Terjun Jagir Desa Kampunganyar Kabupaten Banyuwangi)
Authors: Krismawati Piping Dwi , Hayati Nunung Nuring , Alfiah Rindang
Published: February 2023

Air Terjun Jagir adalah wisata alam yang berada di Desa Kampunganyar, Kecamatan Glagah. Kabupaten Banyuwangi, Provinsi Jawa Timur. Kawasan wisata alam Air Terjun Jagir menjadi destinasi pilihan wisatawan yang berkunjung ke Kabupaten Banyuwangi. Namun pada kondisi eksistingnya, dengan jumlah pengunjung yang banyak wisata Air Terjun Jagir tidak diimbangi dengan fasilitas penunjang wisata yang sesuai. Dalam hal pengembangan wisata sebagian masyarakat sudah mengetahui mengenai pengembangan wisata dan menanggapi secara baik, namun masih banyak juga masyarakat yang belum mengetahui bahkan tidak berpartisipasi terhadap wisata alam Air Terjun Jagir. Penelitian ini memiliki tujuan untuk mengetahui faktor penentu pengembangan kawasan wisata alam Air Terjun Jagir, mengetahui bentuk partisipasi masyarakat Desa Kampunganyar, dan merumuskan arahan pengembangan kawasan wisata alam Air Terjun Jagir berdasarkan partisipasi masyarakat. Penelitian ini menggunakan 2 metode analisis data untuk mencapai tujuan yang diinginkan. Pertama, menggunakan metode Analisis Delphi untuk menentukan faktor-faktor penentu pengembangan Air Terjun Jagir. Kedua, menggunakan Analisis Deskriptif untuk menentukan bentuk-bentuk partisipasi masyarakat Desa Kampunganyar dan untuk menentukan arahan pengembangan kawasan wisata alam Air Terjun Jagir. Hasil penelitian ini yaitu terdapat 6 faktor penentu yang mempengaruhi pengembangan Air Terjun Jagir. Sedangkan bentuk partisipasi yang diberikan masyarakat Desa Kampunganyar terbanyak yaitu partisipasi tenaga dan tingkat partisipasinya berada di tingkat consultation yang tergolong dalam Tokenis.  Serta arahan pengembangannya ditentukan berdasarkan faktor attraction, accessibility, amenities, ancillary, sumberdaya manusia, dan lingkungan yang disesuiakan dengan kebijakan atau teori yang berkaitan.
MATRIK TRANSFORMASI PADA RUANG BARISAN ORLICZ
Authors: Haryadi Haryadi
Published: February 2023

In this study will be characterized a matrix that maps the space of the Orlicz sequence space to the space of the bounded sequence and the convergence sequence. This study is carried out by generalized the matrix mapping on lp  space, 1<=p<\infty, to the Orlicz sequence space. This results establishes a necessary and sufficient conditions for a matrix that maps the Orlicz sequence space to the bounded sequence space,  convergence to  sequence space and the convergence sequence space.
Indeks Kepuasan Masyarakat (IKM) Pada Mal Pelayanan Publik Kota Banjarbaru Tahun 2022
Authors: Rizky Subhan Rizky Subhan
Published: February 2023

In this study, the Banjarbaru City Public Service Mall will be the object of this study. The research aims to analyze the community satisfaction index (IKM). Provisions regarding the community satisfaction index (IKM), according to the Minister of Administrative Reform where there is a decree number 14 of 2017 concerning general guidelines for compiling the community satisfaction index for government agency service units. The approach used in this study is a quantitative method approach, with measurements using a Likert Scale. The sample used in this study was 150 respondents, with the sampling technique of probability sampling. Data analysis techniques in this study were analyzed beforehand by testing the validity and reliability tests then processing the data with a data tabulation system to draw conclusions about the community satisfaction index. The overall community satisfaction index for all indicators obtained an IKM value of 3.94 and an IKM conversion value of 78.8 which is in the category of service quality B and is in the good performance category. This shows that the services provided by public service mall officers are carried out properly. So that people are satisfied with the performance of the Banjarbaru city public service mall. Keywords: Public Service, Community Satisfaction, Community Satisfaction Index, Public Service Mall
ANALISIS 3 DIMENSI KESTABILAN LERENG AKIBAT AKTIVITAS PELEDAKAN PADA TEROWONGAN
Authors: Akbar Fadhilla , Sulistianto Budi , Karian Tri
Published: February 2023

Aktivitas pemberaian batuan menggunakan peledakan pada penggalian terowongan dapat menghasilkan getaran yang akan berpengaruh terhadap lingkungan. Tidak hanya berpengaruh pada terowongan itu sendiri, tetapi juga pada permukaan di atas terowongan tersebut. Penelitian ini dilakukan untuk mencoba menganalisis kestabilan lereng permukaan akibat aktivitas peledakan dalam terowongan. Analisis ini dibantu dengan perangkat lunak dari Rocscience yaitu Slide3, Slide2, dan RS2 untuk memperoleh nilai faktor keamanan dan nilai perpindahan sekitar lereng pemukiman warga yang berada di atas terowongan. Pengambilan conto batuan dan tanah (pemboran geoteknik) akan diuji di laboratorium untuk memperoleh data geoteknik merupakan kegiatan awal dari penelitian ini. Pemantauan dan pengukuran getaran akibat kegiatan peledakan di Terowongan 11 dilakukan pada jarak 109 m dari titik peledakan. Hasil nilai PVS 1,89 mm/s, PPA longitudinal 0,071 g dan PPD 0,003 mm. Nilai PPA dan PPD tersebut digunakan sebagai masukan dan validasi untuk analisis numerik pada penelitian ini. Pemodelan lereng dibuat mendekati kondisi aktual untuk dianalisis, seperti geometri hingga parameter masukan pada model. Hasil analisis menunjukkan nilai faktor kemanan pada lereng permukaan terowongan sebelum dan ketika dilakukan peledakan adalah sebesar 1,450 dan 1,247 yang dapat dinyatakan stabil. Nilai perpindahan dari hasil analisis numerik juga menunjukkan hasil kurang dari 0,5 cm. Dengan nilai perpindahan tersebut, maka getaran akibat aktivitas peledakan tidak menimbulkan kerusakan pada lereng permukaan di atas terowongan.
EFFECT OF FLY ASH ON PRODUCTS OF WATER HYACINTH CATALYTIC PYROLYSIS
Authors: Juwita Rinna , Jefriadi Jefriadi , Aprilianti Khairunnisa , Amalia Mitha , Jelita Rinny
Published: February 2023

The use of alternative energy is needed to overcome the availability of fossil energy sources. One alternative energy source is water hyacinth through a pyrolysis process using a catalyst. Fly ash has the potential to be a catalyst given its very low utilization in Indonesia. Utilization of water hyacinth biomass through a pyrolysis process using a fly ash catalyst was carried out to determine the effect of catalyst activation and the amount of the catalyst on the pyrolysis product. The purpose of this study was to determine the optimum amount of catalyst and the effect of catalyst activation on water hyacinth pyrolysis products. The experiment was carried out in an electric pyrolysis reactor equipped with a condenser as a coolant and a thermocouple. Nitrogen gas is fed into the pyrolysis reactor to create inert conditions that prevent sample burning. The crushed water hyacinth samples were put into the reactor with the fly ash catalyst with a catalyst composition of 0%, 5%, 10%, and 15% of the raw material. The process lasted for 1 hour at 500 oC. The liquid product in the form of bio-oil is collected and then its mass and volume are measured. The solid product in the form of charcoal is taken after the pyrolysis process is complete and the reactor reaches room temperature and then its mass is measured. The highest liquid and solid yields were obtained with 10% activated catalyst variations, namely 39.142% for liquids and 45.144% for solids.
Expert Validation of a Python Test, Reliability, Difficulty and Discrimination Indices
Authors: Belmar Garrido Hector Manuel
Published: February 2023

In recent years, different countries have implemented the teaching of computer programming from the first grade in schools, with the aim of incorporating computational thinking as a new way of thinking that is a necessary skill for scientific and technological development, a fundamental axis for development in the 21st century. Recent reviews of the state of the art have shown that this task is only being carried out by countries that have given space to technology and science, incorporating it at the elementary school level. However, developing countries do not yet consider the significance of the issue, so to date they have not taken the necessary steps in this direction. In addition, learning computer programming is fundamental for countries to join technological development, so that they can be creators of technology and not just users of it. The problem is that there is no didactic development for the teaching of programming, nor validated evaluation instruments to quantify the learning of computer programming. The objective of this research is to validate a programming test that evaluates technical skills in the Python programming language. The instrument proposed to be validated is a 90-item test, which after validation by experts was reduced to 70 items, and after the psychometric analysis that considered the calculation of reliability, difficulty and discrimination indexes, resulted in the proposed 45-item instrument, as a standard instrument for the evaluation of learning in the Python programming language. It should be noted that the validation methodology was carried out using the classical theory of psychometric analysis.
PERSONALIZACIJA USLUGA KROZ NOVE TEHNOLOGIJE
Authors: Mušanović Jelena , Šimić Marko
Published: February 2023

Svrha – Svrha rada je predstaviti sustav koji uči i unaprjeđuje sam sebe prateći odluke gosta i trendove na tržištu te upoznaje interese, želje i navike gostiju. Obrada teme – Snažan napredak digitalne tehnologije, u posljednjih 25 godina, doveo je do novih paradigmi u poslovanju. Hotelijerstvo je djelatnost u kojoj su disruptivne tehnologije poput umjetne inteligencije, strojnog učenja i virtualnih agenata (chatbotovi) počeli mijenjati poslovanje u obliku obavljanja jednostavnijih zadataka korisničke službe, pružanja jednostavnog iskustva prijave u hotel, upravljanja ‘pametnim’ hotelskim sobama koje se mogu prilagoditi, i predviđanja individualnih zahtjeva gostiju. Zahvaljujući sustavima automatizirane segmentacije hotelijerima je omogućeno bolje razumijevanje interesa i želja gostiju te pružanje visoko personalizirane hotelske usluge jačajući istovremeno prodaju smještajnih kapaciteta te podizanje novčane vrijednosti svakog gosta, ali i same sobe. Zaključci – Sustav automatizirane segmentacije gostiju i personalizacije usluga moguće je implementirati u sve faze putovanja gosta. Pri rezervaciji smještaja, sustavi nude gostima dodatne, primamljive, personalizirane te ne nametljive usluge za nadogradnju sobe u skladu s njihovim interesima. Tijekom boravka se gostima nude usluge kroz različite kanale (na IPTVu, kroz osoblje na recepciji, conciergu, u restoranu, kroz Wi-Fi landing page, kroz sustav SMS poruka, kroz mobilne aplikacije) ovisno o tome koji kanal donosi najveću dobit. Nakon odlaska gosta sustav šalje email zahvale kako bi se iskoristio dojam nedavnog boravka te šalje ponuda za iduću sezonu.
Neuroprotective Effect of Curcumin on Factors Involved in Neurogenesis and Angiogenesis in Aged Brain
Authors: Habibian Masoumeh , Moosavi Seyyed Jafar
Published: February 2023

Curcumin is a natural dietary polyphenol which that possesses potent anti-aging and neuroprotective properties through various mechanisms and signaling pathways. This study aimed to investigate the effect of curcumin on factors involved in neurogenesis and angiogenesis in the aged brain. Old female Wistar rats were divided into three equal groups (n=7): control, sham, and curcumin (received curcumin, i.p., 30 mg/kg and 5 days/week for 8 weeks) rats. Curcumin treatment caused a significant increase in the vascular endothelial growth factor (VEGF), Brain-derived neurotrophic factor (BDNF) and anti-apoptotic protein BCl-2 in the brains of aging rats but no significant effect on anti-apoptotic Bax protein. Additionally, curcumin attenuated brain lipid peroxidation and decreased transforming growth factor β1 (TGF-β1). These results suggested that curcumin possesses neuroprotective effects against brain aging, which were mediated by improvment in neurogenesis and angiogenesis. Also, curcumin could alleviate brain aging which may be due to attenuating oxidative stress, inhibiting apoptosis and down-regulating TGF-β1, which in turn enhances VEGF and BDNF. Therefore, curcumin has potential therapeutic value in the treatment of neurological apoptosis, neurogenesis and angiogenesis changes caused by brain aging.
Is ChatGPT a Reliable Source for Writing Review Articles in Catalysis Research? A Case Study on CO2 Hydrogenation to Higher Alcohols
Authors: Zhong Qitong , Tan Xing , Du Ruixing , Liu Jiacheng , Liao Longfei , Wang Cheng , Sun Ruiyan , Tang Zhenchen , Ren Jie , Mebrahtu Chalachew , Zeng Feng
Published: February 2023

ChatGPT is an AI language model trained on vast amounts of text data, including scientific papers, providing a comprehensive understanding of catalysis. However, its reliability in catalysis research is unknown. To evaluate reliability, we compared a ChatGPT-generated review article on heterogeneous catalysts for higher alcohols synthesis by CO2 hydrogenation to published peer-reviewed papers. Although the ChatGPT review article covers most necessary parts, it lacks sufficient discussion of the reaction mechanism. The core sections are too general, being not specific enough to the topic, and contain errors. The lack of citations further increases unreliability. While ChatGPT can provide much content on catalysis, it is insufficient and inaccurate for research on specific topics.
Spatial Study of Enzymatic Activities from Bacterial Isolates in a Mediterranean Urban Park
Authors: Maicas Sergi , Segura-Garcia Jaume
Published: February 2023

The enzymatic activities of bacterial isolates have been widely studied, but a spatial distribution of this activity is rarely focused. New antibiotic-producing microorganisms can be discovered in a more efficient manner if spatial statistical techniques are applied to the distribution of the activity of bacterial isolates in different terrains. This study is focused to generate a series of maps illustrating the spatial distribution of different soil parameters and the inhibition against relative-safe pathogens (like Escherichia coli, Staphylococcus aureus, Klebsiella pneumoniae, Salmonella, Pseudomonas fluorencens and Enterobacter cloacae) in an urban park in València (Spain). This spatial data has demonstrated a higher proportion of isolates was specifically allocated. This routine of data presentation is valuable for understanding bacterial population dynamics at a local level.
Centella Asiatica (GOTU KOLA) TREATMENT ATTENUATES PRO-INFLAMMATORY MEDIATORS IN LIVER OF RATS WITH ELECTRICAL FOOT SHOCK STRESS MODEL
Authors: Sari Dwi Cahyani Ratna , Setyaningsih Wiwit Ananda Wahyu , Mainichi Rizky Nur , Dara Gita Mumtarin , Kemalasari Ratih , Romi Muhammad Mansyur , Ar Rochmah Mawaddah , Arfian Nur
Published: February 2023

Background: Stress induces secretion of cathecolamines and glucocorticoids, which may produce liver injury. Followed by the production of inflammatory mediators, it causes apoptosis. Centella asiatica (CeA) has anti-inflammatory and hepatoprotective effects. The present study aims to determine the role of CeA in the attenuation of liver pro-inflammatory mediator expression in rats with electrical foot shock stress model.
Materials and Methods: Twenty-four Sprague-Dawley rats were randomized into four groups consisted of six rats each: (1) Control group, (2) CeA-treated group, (3) Stress group, and (4) CeA + stress group. Reverse transcriptase PCR of inflammatory and apoptosis markers as well as Real-Time PCR of β2-adrenergic receptor were performed from liver tissues.
Results: Electrical foot shock stress induced up-regulation of NFκB and TNF-α mRNA expressions as pro-inflammatory mediators, compared to control group. This alteration was followed by up-regulation of BAX and β2-adrenergic receptor, as well as the down-regulation of BCl2 compared to control. CeA treatment prevented enhancement of NFκB, TNF-α, TLR-4 and β-adrenergic receptor mRNA expressions, which was followed by down-regulation of BAX and up-regulation of BCl-2, compared to stress group.
Conclusion: CeA prevents secretion of pro-inflammatory chemokines and cytokines as well as apoptotic markers in liver cells through the activation of β2-adrenergic receptor.
STRYCHNOS SPINOSA LAM: COMPREHENSIVE REVIEW ON ITS MEDICINAL AND NUTRITIONAL USES.
Authors: Tittikpina Nassifatou Koko , Atakpama Wouyo , Hoekou Yao , Diop Yerim Mbagnick , Batawila Komlan , Akpagana Komlan
Published: February 2023

Background: Most of the people living in developing countries rely on local remedies from traditional medicines to take care of their healthcare needs. In recent years, the use of medicinal plants increased considerably. Consequently, studies on medicinal plants are necessary to produce more effective drugs with fewer side-effects. This work aims to compile the dispersal data on Strychnos spinosa Lam., a medicinal plant with great therapeutic potential in traditional medicine, on its ethnobotanical uses, chemical compounds, as well as its pharmacological and nutritional effects.
Material and Methods: To achieve the aforementioned aim, electronic databases such as Pubmed, Science Direct, Google scholar, Scopus and SciFinder were scanned.
Results:  Literature survey revealed that S. spinosa is used in the treatment of microbial infections, malaria, trypanosomiasis, intestinal worms, tuberculosis, infertility, gastrointestinal disorders, snake bite, hypertension, and diabetes mellitus among other ailments. The plant is also used as food material. S. spinosa contains many chemical compounds, such as alkaloids, terpenes, sterols, fatty acids, flavonoids, saponin, and others. The fruits are a source of important nutrients such as carbohydrates, sugars, proteins, vitamins and fibres. Experimental studies have shown numerous pharmacological properties, including antimicrobial, antiplasmodial, anti-trypanosomal, anti-leishmanial, anti-nematicidal, anti-inflammatory, anti-oxidant, antidiabetic and other activities.
Conclusion: This review article provides comprehensive information on S. spinosa and its various extracts. Due to the promising effects of the plant extracts on various diseases and its nutritional values, there is a need for toxicity studies and clinical trials to assess the effects of its identified bioactive compounds.
ETHNO MEDICINAL SURVEY AND EVALUATION OF TWO RECIPES USED IN MANAGING SICKLE CELL DISEASE IN ILE-IFE COMMUNITY OF OSUN-STATE, NIGERIA.
Authors: Cyril-Olutayo Mojisola Christianah , Ajayi Dorcas O , Odunowo Olayinka O
Published: February 2023

Background: Ethno-medicinal survey of herbal recipes used in managing sickle cell disease in Ile-Ife, Osun-State, Nigeria was carried out and two recipes selected for antisickling studies.
Materials and Methods: Information was obtained using semi-structured questionnaires and open interview from respondents consisting of herb sellers, traditional medical practitioners, artisans and traders in two local government areas of Ife. Two recipes from the survey were selected for antisickling studies. Aqueous extract of each recipe was obtained by boiling the constituents in water for 1 h while the hydro ethanolic extracts were obtained by maceration in 70% ethanol for 72 h. Inhibitory and reversal antisickling properties were assessed using sodium metabisulphite as deoxygenating agent, vanillic acid (inhibitory agent), para-hydroxybenzoic (reversal agent) acid as positive controls while phosphate buffered saline was employed as negative control.
Results: Fifty four recipes comprising forty six plants were obtained from the ethno-medicinal survey. The respondents comprised of 44% men and 56% women. The most frequently and commonly used plants belong to family Fabaceae. The inhibitory and reversal activities of the aqueous extract of recipe 1 (81.37± 1.09%, 88.56 ±1.38% respectively) were significantly (p < 0.05) higher than recipe 2 (78.51 ± 0.78% inhibition and 79.8 ± 2.16% reversal) at same concentration. The hydro-alcoholic extracts of recipes 1 and 2 gave highest inhibitory activities at 0.5 mg/mL (69.25 ±1.30% and 68.28 ±2.78% respectively).
Conclusion: This study documented the medicinal plants and recipes used in Ile-Ife for managing sickle cell disease, and validated the ethno-medicinal claim of two recipes.
Распространение вариантов вируса SARS-COV-2, вызывающих озабоченность (VOC) на основе количества их геномов, депонированных в базу данных GISAID за неделю с 11.02.2023 г. по 17.02.2023 г.
Authors: Дмитриева Людмила , Краснов Ярослав , Чумачкова Елена , Осина Наталья , Зимирова Анастасия , Иванова Александра , Карнаухов Игорь , Караваева Татьяна , Щербакова Светлана , Кутырев Владимир
Published: February 2023

В обзоре представлена информация по циркулирующим в настоящее время вариантам вируса SARS-COV-2 вызывающих озабоченность (VOC), геномные последовательности которых размещены в международной базе данных GISAID за неделю с 11 по 17 февраля 2023 г
Experiment and Simulation Analysis of the Vibration Response of the Rotor-bearing System
Authors: Qian Bing , Ran Yinkang , Ding Qiang , Sun Weipeng , Ma Chenyuan
Published: February 2023

The unbalanced mass of the rotor-bearing system may cause abnormal vibration of the rotor-bearing system, which may affect the safe operation of the system in severe cases. In this paper, the rotor-bearing system fault simulation test bench and MADYN 2000 were used to test and simulate the single-disk shafting rotor mass unbalance fault. The research analyzes the influence of speed, unbalanced mass, support stiffness, and phase of unbalanced mass on the vibration response of the rotor-bearing system. The results show that when the speed is higher than the first-order critical speed, after the rotor starts, the amplitude gradually increases with the speed, reaches the peak at the first-order critical speed, and then gradually decreases to a stable value. Due to the anisotropy of the bearing support, the rotor has different amplitudes in each direction, but the change trend is the same, the support stiffness is small, and the stable value is reached faster. When the rotation speed and the unbalanced mass phase are the same, the rotor amplitude and the rotor unbalanced mass have a linear relationship. When the speed and unbalanced mass are the same, the rotor amplitude fluctuates with the change of the loading phase, and the fluctuation period is π. The research results have certain reference significance for the fault diagnosis and dynamic characteristics analysis of the unbalanced response of the rotor-bearing system.
A Neuromechanical Control Model For Rhythmic and Discrete Movements Based on Central Pattern Generator (CPG)
Authors: Nia Nafiseh Ghaffar , Bahrami Fariba , Kaplanoglu Erkan , Nasab Ahad
Published: February 2023

Movement is one of the essential characteristics of living beings. Despite the diversity of animal species and the apparent differences, standard features exist between their movement systems that follow a particular pattern. The movements can mainly be divided into discrete and rhythmic categories controlled by the central nervous system. Scientists usually consider these two types of motion separately in the control system and use different methods and resources to produce and model them. Proposing a unified and comprehensive model for generating and controlling rhythmic and discrete movement with the same control system is more valuable, albeit challenging. The present study provides a single neuromechanical control model for producing and controlling rhythmic and discrete movements. This model consists of a neural oscillator, the central pattern generator (CPG), coupled with inhibitory and excitatory paths to drive the flexor and extensor muscles. The computational model of this study follows the Hodgkin-Huxley (HH) equations. The structure of the model, the factors involved in creating the motion, and the oscillation were analyzed in great detail. It was found that supraspinal input and motor neuron feedback, as the motor control parameters, play an essential role in the activity and directly impact the production and control of rhythmic and discrete movements. According to these parameters, a neuromechanical model that can create both rhythmic and discrete movement is presented. The model also addresses the switching mechanism between rhythmic and discrete states.
Klebsiella michiganensis: A nitrogen-fixing endohyphal bacterium from Ustilago maydis
Authors: Liang Pengyu , Jiang Jianwei , Sun Zhengxiang , Li Yanyan , Yang Chunlei , Zhou Yi
Published: February 2023

Ustilago maydis is a pathogenic fungus in Basidiomycota causing corn smut disease. A strain of U. maydis YZZF202006 was isolated from the tumor of corn smut collected from Jingzhou city in China. The intracellular bacteria were confirmed inner hyphal of the strain YZZF202006 by PCR amplification and fluorescence in situ hybridization (FISH) and SYTO-9. An endohyphal bacterium YZUMF202001 was isolated from the protoplasts of the strain YZZF202006. It was gram-negative, short rod-shaped with smooth light yellow colony. The endohyphal bacterium was genomic evidenced as Klebsiella michiganensis on the basis of average nucleotide identity (ANI) analysis and the phylogram. And then K. michiganensis was GFP-Labeled and reintroduced into U. maydis, which confirmed the bacterium can live in hpyphal of U.maydis. The bacterium can grow on N-free culture media. Its nitrogenase activity was reached av. 646.25 ± 38.61 nmol·mL−1·h−1 C2H4 by acetylene reduction assay. A cluster of nitrogen fixation genes (nifJHDKTXENXUSVWZMFLABQ) was found from its genome. The endohyphal K. michiganensis may play an important role to help nitrogen fixation for fungi in the future.
Research on Automatic Driving Strategy Optimization Method of High-speed Train Based on Artificial Fish Swarm Algorithm
Authors: bai shuai , qiao yaqiong , liang zhiguo , liu qingmeng , guo liang , wang tuo
Published: February 2023

The existing automatic driving technology of high-speed railway trains has been able to complete the automatic driving of trains in normal scenes. and it has begun to develop in the direction of improving operational efficiency and optimizing driving strategies. Based on the current automatic driving technology, this paper proposes an optimization method of automatic driving strategy for high-speed trains based on artificial fish swarm algorithm, aiming at reducing train energy consumption, improving train parking accuracy, train punctuality and passenger comfort and train speed protection. Firstly, based on train dynamics, the dynamic parameter model of train in running process is described. Through the train dynamic parameter model, combined with the line information such as speed limit, slope and phase separation area, an artificial fish swarm algorithm is designed, which aims at safety, punctuality, energy saving, comfort and parking accuracy. The artificial fish swarm algorithm is used to simulate the optimal driving strategy of train running and generate the train driving curve. Finally, the driving curve simulated by artificial fish swarm algorithm is compared with the driving curve simulated by genetic algorithm and the actual driving curve of Beijing-Shenyang high-speed train, which shows that the proposed method is effective and the convergence speed of artificial fish swarm algorithm is better than that of genetic algorithm.
Sustainable Settlement Area: Threats of Environmental Change Due to Yogyakarta International Airport
Authors: Rusdiyanto Edi , Sumartono Sumartono , Munawir Abdillah
Published: February 2023

Yogyakarta International Airport (YIA) is an airport with an aerotropolis concept inspired by the fact that the airport has evolved into a motor of business and urban development. This condition greatly affects the development of settlement areas around YIA. This study aims to analyze changes in land cover area and the sustainability of settlement areas around YIA. This study uses a mapping approach with satellite image interpretation and Multidimensional Scaling (MDS) sustainability analysis with Rap-settlement software. The results of the analysis of changes in land cover from fields/moorlands to built-up land are 94 ha, then garden/plantation land to built-up land is 77 ha and rice fields to built-up land are 23 ha. Changes in the built-up land in the YIA area occur in almost all areas around YIA, especially those directly adjacent to Purworejo Regency. The land changes, mostly follow the aerotropolis planning concept, thus turning the airport area into a new destination for tourists to meet and interact around the airport. The sustainability status of settlement areas around YIA is currently quite sustainable. There are 13 levering attributes that need intervention on the economic, social and ecological dimensions which are sensitive attributes for the sustainability of the development of settlement areas around YIA.
Effectiveness of a telerehabilitation intervention using Recovery APP of Long COVID patients: A randomized, three-month follow-up clinical trial
Authors: Samper-Pardo Mario , León-Herrera Sandra , Oliván-Blázquez Bárbara , Méndez-López Fátima , Domínguez-García Marta , Sánchez-Recio Raquel
Published: February 2023

Background: Long COVID pathology affects patient quality of life. Different telerehabilitation (TR) strategies are being implemented to improve post-COVID symptoms. The main objective of this study is to analyze the efficacy of the ReCoVery Application (APP) over a three-month period. A second objective is to identify significant models associated with improvement.
Methods: An open-label and randomized clinical trial (RCT) was conducted, using two parallel groups. A total of one hundred Long COVID patients participated in the study. Quality of life was the main variable examined. A statistical comparison of pre-three-month groups was made using T-student and chi-square, and linear regressions were performed to analyze the profile of those patients who improved.
Results: Adherence to the ReCoVery APP was low, and was not significantly more effective as compared to no intervention. However, the time of use of the ReCoVery APP, an increase in the self-efficacy construct and health literacy could contribute to the recovery of Long COVID patients.
Conclusion: It is necessary to improve Long COVID patient adherence to TR. Furthermore, future RCTs are still needed to assess the efficacy of TR in these patients.
Association between High Iron Status of pregnant women and Gestational Diabetes Mellitus in Black Lion Specialized Hospital and Gandhi Memorial Hospital, Addis Ababa: A Case-Control Study
Authors: Debele Betelihem Sime , Endris Bilal Shikur , Mengistu Yalemwork Getnet , Haider Professor Jemal Ali
Published: February 2023

Background: Although excess iron in the body is reported to disrupt glucose homeostasis leading to beta cell damage and death such information is unavailable in the studied sites and thus we examined the association between high iron status of pregnant women and occurrence of Gestational Diabetes.
Methods: A hospital based case control study was conducted from March to July 2022 among 128 pregnant women, 64 cases (pregnant women with GDM) and 64 controls (non-GDM pregnant women) in black lion specialized hospital and Gandhi memorial hospital. The data were collected through document reviews, face-to-face interviews and laboratory test were done. SPSS software version 24 was used for data processing and analysis. Binary logistic regressions were used to assess the association between the predictor variables and gestational diabetes mellitus.
Result: A total of 128 of pregnant women comprising of 64 cases and 64 controls were included in the study. The mean age of respondents was 31.17±4.97 year among cases and 27.59±4.70 year among the controls. The concentration of serum ferritin were significantly higher among GDM cases (53.83±23.39 ng/ml) than controls (29.8±18.408 ng/ml). Physical activity AOR (2.68, CI: 1.031-6.96), parity AOR (3.48, CI: 1.197-10.11) and abortion AOR (3.360, CI: 1.25-8.98) were among the significant factors associated with gestational diabetes mellitus.
Conclusion: The occurrence of gestational diabetic mellitus was significantly associated with the higher Serum ferritin levels, while such association was not observed with the hemoglobin level. Thus, it is time to revise the blanket iron supplementation strategy to all pregnant women to avert the odds of developing GDM.