bluuebunny/crossref_metadata_2025 huggingface dataset:
Un Suplemento Al Fr. 2 Livrea (= Lomiento) de Cércidas (P.oxy. 1082, Col. Vi, 8-9)
Authors: López Cruces Juan Luis
Published: December 2023

Se propone un suplemento para Cércidas, fr. 2, 22-3 Livrea2 (= 2, 23-4 Lomiento) que es coherente con la idea de que la primera porción perdida del poema (P.Oxy. 1082, col. VI, 1-9) contenía la descripción de los peligros de la tempestad en el mar como símbolo del amor violento y lujurioso.
De héroes y versos
Authors: Palomino Tizado Natalia
Published: December 2023

De héroes y versos. Preámbulo para políticas épicas
Dedicado a la profesora doña Mercedes Blanco
Authors: Gómez Canseco Luis
Published: December 2023

Dedicado a la profesora doña Mercedes Blanco
La heroica Albión
Authors: Cacho Casal Rodrigo
Published: December 2023

El presente estudio ofrece una interpretación tipológica de dos episodios clave dentro de La Dragontea (1598) de Lope de Vega: la resistencia montada por los cimarrones de Santiago del Príncipe contra Francis Drake y la captura del pirata Richard Hawkins en las costas del Perú. A la luz de esta lectura, enfocada en estos personajes y sus vicisitudes, me propongo reevaluar la obra ofreciendo una interpretación más matizada de La Dragontea en la que las fronteras entre el bien y el mal son más permeables de lo que pudiera parecer.
Dos versiones de la misma historia
Authors: Rascón García Elisabet M.
Published: December 2023

En este artículo se compara la versión que hizo Duque de Estrada en sus Octavas rimas y en sus Comentarios de un enfrentamiento marítimo entre el marqués de Santa Cruz y el corsario Ali. Con ello se pretende dar cuenta de la forma en la que el soldado reescribe determinados episodios de su vida, pero, sobre todo, se busca dar a conocer otra obra suya, las Octavas rimas, escrita según los criterios de la épica de la pólvora y apenas explorada.
Rancang bangun inverter sinusoida dengan frekuensi variabel
Authors: Luqman Mohammad , Priyadi Bambang , Sumarno Agus Sukoco Heru
Published: December 2023

Alat untuk mengubah daya dc menjadi daya ac disebut dengan inverter. Inti dari inverter sinusoida terletak pada kontrol switching, dimana bentuk gelombang dan frekuensi ditentukan pada alat kontrol, salah satunya adalah gelombang SPWM. Dipasaran telah tersedia pembangkit SPWM seri EGS-002, yang beroperasi pada frekuensi tetap 50 HZ atau 60 Hz, sehingga tidak bisa di gunakan untuk membangkitkan listrik dengan frekuensi variabel. Sebagai pembangkit sinyal SPWM dan penentu frekuensi variabel digunakan mikrokontroller arduino Uno. Frekuensi yang direncanakan adalah 10Hz sampai dengan 50Hz. Kontrol frekuensi direncanakan menggunakan variabel resistor. Sebagai driver switching menggunakan H-bridge jenis L-298 yang sudah tersedia dalam bentuk modul driver motor L-298 dan transformator konvensional sebagai penaik tegangan. Hasil yang telah dicapai adalah inverter yang bisa menghasilkan sinyal SPWM dengan frekuensi bisa diatur mulai 9,7Hz sampai dengan 58,14Hz melalui variabel resistor eksternal. Dan sesudah melalui tranformator/ filter akan menghasilkan sinyal sinusoida dengan frekuensi yang sama.
ABSTRACT A device for converting dc power into ac power is called an inverter. The essence of the sinusoidal inverter lies in the switching control, where the waveform and frequency are determined by the controller, one of which is the SPWM waveform. In the market, there is an EGS-002 series SPWM generator, which operates at a fixed frequency of 50 Hz or 60 Hz, so it cannot be used to generate electricity with variable frequency. As a SPWM signal generator and variable frequency determinant, Arduino Uno microcontroller is used. The planned frequency is 10Hz to 50Hz. Frequency control is planned using a variable resistor. As a switching driver, it uses an L-298 type H-bridge which is already available in the form of an L-298 motor driver module and a conventional transformer as a voltage booster. The result that has been achieved is an inverter that can produce SPWM signals with adjustable frequency from 9.7Hz to 58.14Hz through an external variable resistor. And after going through the transformer / filter will produce a sinusoidal signal with the same frequency.
Changes in industry marketing of electronic nicotine delivery systems on social media following FDA's prioritized enforcement policy: a content analysis of Instagram and Twitter posts
Authors: Guillory Jamie , Trigger Sarah , Ross Ashley , Lane Stephanie , Kim Annice , Nonnemaker James , Liu Sherry T. , Snyder Kimberly , Delahanty Janine
Published: December 2023

Background

In February 2020, FDA prioritized enforcement of flavored (other than tobacco- or menthol-flavored) cartridge-based electronic nicotine delivery systems (ENDS) without premarket authorization. To explore potential marketing changes, we conducted a content analysis of brands' social media posts, comparing devices and flavors before/after the policy.

Methods

We sampled up to three posts before (November 6, 2019–February 5, 2020) and after the policy (February 6–May 6, 2020) from brands' Instagram (n = 33) and Twitter (n = 30) accounts (N = 302 posts). Two analysts coded posts for device type and flavor. We summarized coded frequencies by device, flavor, and device-flavor combination, and by platform.

Results

In posts mentioning devices and flavors, those featuring flavored (other than tobacco- or menthol-flavored) cartridge-based devices (before: 2.5%; after: 0%) or tobacco- or menthol-flavored cartridge-based devices (before: 0%; after: 2.8%) were uncommon while any flavor disposables were most common (before: 10.8%; after: 14.6%) particularly after the policy. Half of posts featured devices without flavor (before: 50.0%; after: 50.0%) and one-fifth had no device or flavor references (before: 21.5%; after: 18.8%).

Conclusions

In the months before and after the policy, it appears ENDS brands were not using social media to market flavored (excluding tobacco- or menthol-flavored) cartridge-based ENDS (i.e., explicitly prioritized) or tobacco- or menthol-flavored cartridge-based devices (i.e., explicitly not prioritized). Brands were largely not advertising specific flavored products, but rather devices without mentioning flavor (e.g., open/refillable, disposable devices). We presented a snapshot of what consumers saw on social media around the time of the policy, which is important to understanding strategies to reach consumers in an evolving ENDS landscape.
Simulating immunosuppressive mechanism of Microplitis bicoloratus bracovirus coordinately fights Spodoptera frugiperda
Authors: Li Xing-Cheng , Ma Yin-Chen , Long Jin , Yan Xiang , Peng Nan-Nan , Cai Cheng-Hui , Zhong Wen-Feng , Huang Yong-Biao , Qiao Xin , Zhou Li-Xiang , Cai Qiu-Chen , Cheng Chang-Xu , Zhou Gui-Fang , Han Yun-Feng , Liu Hong-Yu , Zhang Qi , Tang Hong-Mei , Meng Jiang-Hui , Luo Kai-Jun
Published: December 2023

Parasitoid wasps control pests via a precise attack leading to the death of the pest. However, parasitoid larvae exhibit self-protection strategies against bracovirus-induced reactive oxygen species impairment. This has a detrimental effect on pest control. Here, we report a strategy for simulating Microplitis bicoloratus bracovirus using Mix-T dsRNA targeting 14 genes associated with transcription, translation, cell–cell communication, and humoral signaling pathways in the host, and from wasp extracellular superoxide dismutases. We implemented either one-time feeding to the younger instar larvae or spraying once on the corn leaves, to effectively control the invading pest Spodoptera frugiperda. This highlights the conserved principle of “biological pest control,” as elucidated by the triple interaction of parasitoid-bracovirus-host in a cooperation strategy of bracovirus against its pest host.
Trophic diversity of chemosymbiont hosts in deep-sea hydrothermal vents using amino acid nitrogen isotopes
Authors: Suh Yeon Jee , Ju Se-Jong , Kim Min-Seob , Choi Hyuntae , Shin Kyung-Hoon
Published: December 2023

Chemosymbiotic species inhabiting deep-sea hydrothermal vents are known to rely on microbial symbionts for nutrition. However, the relative contributions of heterotrophic energy sources to their diets remain poorly understood. In this study, we investigate the trophic positions (TP) of symbiont-bearing taxa, including vent mussels, snails, and shrimps, and examine the contribution of copepods and detrital organic matter (OM) to the food chain. Amino acid nitrogen isotopic compositions (δ15NAA) were used to investigate the TP of vent mussels (Bathymodiolus septemdierum and Gigantidas vrijenhoeki), snails (Alviniconcha spp.), and shrimps (Alvinocaris sp. and Rimicaris kairei) from two different vent environments. δ15NAA values in copepods and OM were also measured. Microbial resynthesis index (ΣV) was calculated to predict the contribution of reworked OM as an energy source to the hydrothermal vent ecosystem. Variations in TP were observed among vent mussels and snails from different vent environments, with higher TP in species from diffusing vents than in those from black smoker vents. Shrimps dwelling in a single diffusing vent exhibited distinct TP, suggesting that microhabitat and phylogeny may influence their energy acquisition. Notably, copepods occupied higher TPs than expected, possibly owing to the consumption of detrital OM. Our findings provide new insights into the trophic diversity of chemosymbiotic species in deep-sea hydrothermal vents and demonstrate the utility of δ15NAA analysis as a tool for unraveling food web dynamics and ecosystem functioning in these unique environments.
Transcranial burst electrical stimulation contributes to neuromodulatory effects in the rat motor cortex
Authors: Nguyen Thi Xuan Dieu , Kuo Chi-Wei , Peng Chih-Wei , Liu Hao-Li , Chang Ming-Yuan , Hsieh Tsung-Hsun
Published: December 2023

Background and objective

Transcranial Burst Electrical Stimulation (tBES) is an innovative non-invasive brain stimulation technique that combines direct current (DC) and theta burst stimulation (TBS) for brain neuromodulation. It has been suggested that the tBES protocol may efficiently induce neuroplasticity. However, few studies have systematically tested neuromodulatory effects and underlying neurophysiological mechanisms by manipulating the polarity of DC and TBS patterns. This study aimed to develop the platform and assess neuromodulatory effects and neuronal activity changes following tBES.

Methods

Five groups of rats were exposed to anodal DC combined with intermittent TBS (tBES+), cathodal DC combined with continuous TBS (tBES−), anodal and cathodal transcranial direct current stimulation (tDCS+ and tDCS−), and sham groups. The neuromodulatory effects of each stimulation on motor cortical excitability were analyzed by motor-evoked potentials (MEPs) changes. We also investigated the effects of tBES on both excitatory and inhibitory neural biomarkers. We specifically examined c-Fos and glutamic acid decarboxylase (GAD-65) using immunohistochemistry staining techniques. Additionally, we evaluated the safety of tBES by analyzing glial fibrillary acidic protein (GFAP) expression.

Results

Our findings demonstrated significant impacts of tBES on motor cortical excitability up to 30 min post-stimulation. Specifically, MEPs significantly increased after tBES (+) compared to pre-stimulation (p = 0.026) and sham condition (p = 0.025). Conversely, tBES (−) led to a notable decrease in MEPs relative to baseline (p = 0.04) and sham condition (p = 0.048). Although tBES showed a more favorable neuromodulatory effect than tDCS, statistical analysis revealed no significant differences between these two groups (p > 0.05). Additionally, tBES (+) exhibited a significant activation of excitatory neurons, indicated by increased c-Fos expression (p < 0.05), and a reduction in GAD-65 density (p < 0.05). tBES (−) promoted GAD-65 expression (p < 0.05) while inhibiting c-Fos activation (p < 0.05), suggesting the involvement of cortical inhibition with tBES (−). The expression of GFAP showed no significant difference between tBES and sham conditions (p > 0.05), indicating that tBES did not induce neural injury in the stimulated regions.

Conclusion

Our study indicates that tBES effectively modulates motor cortical excitability. This research significantly contributes to a better understanding of the neuromodulatory effects of tBES, and could provide valuable evidence for its potential clinical applications in treating neurological disorders.
Distinct resting-state effective connectivity of large-scale networks in first-episode and recurrent major depression disorder: evidence from the REST-meta-MDD consortium
Authors: Zhu Yao , Huang Tianming , Li Ruolin , Yang Qianrong , Zhao Chaoyue , Yang Ming , Lin Bin ,   the DIRECT Consortium, Li Xuzhou
Published: December 2023

Introduction

Previous studies have shown disrupted effective connectivity in the large-scale brain networks of individuals with major depressive disorder (MDD). However, it is unclear whether these changes differ between first-episode drug-naive MDD (FEDN-MDD) and recurrent MDD (R-MDD).

Methods

This study utilized resting-state fMRI data from 17 sites in the Chinese REST-meta-MDD project, consisting of 839 patients with MDD and 788 normal controls (NCs). All data was preprocessed using a standardized protocol. Then, we performed a granger causality analysis to calculate the effectivity connectivity (EC) within and between brain networks for each participant, and compared the differences between the groups.

Results

Our findings revealed that R-MDD exhibited increased EC in the fronto-parietal network (FPN) and decreased EC in the cerebellum network, while FEDN-MDD demonstrated increased EC from the sensorimotor network (SMN) to the FPN compared with the NCs. Importantly, the two MDD subgroups displayed significant differences in EC within the FPN and between the SMN and visual network. Moreover, the EC from the cingulo-opercular network to the SMN showed a significant negative correlation with the Hamilton Rating Scale for Depression (HAMD) score in the FEDN-MDD group.

Conclusion

These findings suggest that first-episode and recurrent MDD have distinct effects on the effective connectivity in large-scale brain networks, which could be potential neural mechanisms underlying their different clinical manifestations.
Overview and characterization of penile cancer content across social media platforms
Authors: Ortiz-Guerra Ruben Alejandro , Jaime-Casas Salvador , Martinez-Cannon Bertha Alejandra , Ariza-Avila Jose C. , González-Morales Ana P. , Bardan-Duarte Andrea , Remolina-Bonilla Yuly A. , Spiess Philippe E. , Bourlon Maria T.
Published: December 2023

Background

Social media platforms (SMP) are an emerging resource that allows physicians, patients, and families to converse on cancer prevention, diagnosis, and treatment. We aimed to characterize penile cancer (PC) content shared on SMP.

Methods

We searched PC posts on Twitter, Facebook, and Instagram from July 1st, 2021, through June 30th, 2022. Two independent, blinded reviewers analyzed the hashtags: #PenileCancer, #PenileCancerAwareness, and #PenileNeoplasm. Descriptive statistics were used for posts characterization, Pearson´s correlation coefficient for associations, and Cohen’s weighted kappa coefficient for inter-rater agreement rate.

Results

A total of 791 posts were analyzed, with Twitter accounting for 52%, Facebook for 12.2%, and Instagram for 35.5%, and. Most posts originated from high-income countries, such as the United Kingdom (48.8%). We found no correlation between the number of posts with PC incidence (p = 0.64) or users on SMP (p = 0.27). Most accounts were classified as “support and awareness communities” (43.6%) and “physicians and clinical researchers” (38.2%). Urology was the most common medical specialty to post (60.9%), followed by oncology (11.3%). Most posts were classified as “prevention and awareness for users” (45.1%). Global inter-reviewer agreement rate was almost perfect (k=0.95; p ≤ 0.01). On Twitter, “physicians and clinical researchers” shared more content on “treatment updates and medical papers published in medical journals,” while on Facebook and Instagram, “support and awareness communities” focused on “personal and support comments.”

Conclusion

Overall, the number of PC posts was low compared to other neoplasms across the SMP evaluated in this study. “Physicians and clinical researchers” shared more content on Twitter, while “support and awareness communities” on Facebook and Instagram. Encouraging the use of a common SMP among the medical community and general users could lead to a more effective communication between physicians, patients, and support groups, and to increased awareness of PC.
Impact of the COVID-19 pandemic on antidepressant and antipsychotic use among children and adolescents: a population-based study
Authors: Antoniou Tony , Pajer Kathleen , Gardner William , Penner Melanie , Lunsky Yona , Tadrous Mina , Mamdani Muhammad , Gozdyra Peter , Juurlink David N. , Gomes Tara
Published: December 2023

Background

The COVID-19 pandemic was associated with increases in the prevalence of depression, anxiety and behavioural problems among children and youth. Less well understood is the influence of the pandemic on antidepressant and antipsychotic use among children. This is important, as it is possible that antidepressants and antipsychotics were used as a “stop-gap” measure to treat mental health symptoms when in-person access to outpatient care and school-based supportive services was disrupted. Furthermore, antipsychotics and antidepressants have been associated with harm in children and youth. We examined trends in dispensing of these medications two years following the pandemic among children 18 years of age and under in Ontario, Canada.

Methods

We conducted a population-based time-series study of antidepressant and antipsychotic medication dispensing to children and adolescents ≤18 years old between September 1, 2014, and March 31, 2022. We measured monthly population-adjusted rates of antidepressant and antipsychotics obtained from the IQVIA Geographic Prescription Monitor (GPM) database. We used structural break analyses to identify the pandemic month(s) when changes in the dispensing of antidepressants and antipsychotics occurred. We used interrupted time series models to quantify changes in dispensing following the structural break and compare observed and expected use of these drugs.

Results

Overall, we found higher-than-expected dispensing of antidepressants and antipsychotics in children and youth. Specifically, we observed an immediate step decrease in antidepressant dispensing associated with a structural break in April 2020 (−55.8 units per 1,000 individuals; 95% confidence intervals [CI] CI: −117.4 to 5.8), followed by an increased monthly trend in the rate of antidepressant dispensing of 13.0 units per 1,000 individuals (95% CI: 10.2–15.9). Antidepressant dispensing was consistently greater than predicted from September 2020 onward. Antipsychotic dispensing increased immediately following a June 2020 structural break (26.4 units per 1,000 individuals; 95% CI: 15.8–36.9) and did not change appreciably thereafter. Antipsychotic dispensing was higher than predicted at all time points from June 2020 onward.

Conclusion

We found higher-than-expected dispensing of antidepressants and antipsychotics in children and youth. These increases were sustained through nearly two years of observation and are especially concerning in light of the potential for harm with the long-term use of antipsychotics in children. Further research is required to understand the clinical implications of these findings.
Effect of Danshen for improving clinical outcomes in patients with bladder cancer: a retrospective, population-based study
Authors: Chen Yi-Hsin , Chen Chih-Tsung , Wu Han-Ping
Published: December 2023

Introduction: Traditional Chinese Medicine (TCM) has a broad application in healthcare, with Danshen being a notable herb used in Eastern medicine for cancer treatment. This study aims to explore the relationship between Danshen use and cardiovascular risks among bladder cancer patients.

Methods: Patients were selected based on a confirmed diagnosis of bladder cancer with specific inclusion and exclusion criteria to control for certain comorbidities and treatments. Utilizing Taiwan’s National Health Insurance data from 2003 to 2013, this retrospective, population-based study identified three groups: 525 patients treated with Danshen, 6,419 patients not treated with TCM, and 4,356 patients treated with TCM but not with Danshen. The Cox proportional hazard model was employed to estimate the risks of Major Adverse Cardiovascular Events (MACE) and mortality while accounting for various confounders.

Results: The overall incidence of MACEs was significantly lower in the Danshen group (5%) compared to the TCM (8.1%) and non-TCM (9.9%) groups (p < 0.001). The Cox model revealed that bladder cancer patients treated with Danshen had the lowest risk of MACE (adjusted hazard ratio, 0.56; 95% confidence interval, 0.38–0.84) and all-cause mortality (adjusted hazard ratio, 0.60; 95% confidence interval, 0.44–0.82).

Discussion: The findings suggest that Danshen reduces the risk of MACE and all-cause mortality in bladder cancer patients, highlighting its potential benefits. This underpins the necessity for further research to substantiate the cardiovascular benefits of Danshen in bladder cancer patients and potentially broaden its application in oncology healthcare.
Research hotspots and trend analysis of cell transplantation in traumatic spinal cord injury: a bibliometric and visualized analysis
Authors: Guo Yuhuai , Gao Bowen , Sun Shilin , Li Jianuo , Lv Xiaolin , Yin Hongna , Sun Zhongren , Cai Shuo
Published: December 2023

Background: A traumatic spinal cord injury (TSCI) can lead to severe nerve damage and disability. Cell transplantation therapy has shown great potential in the reconstruction of damaged spinal cords and promoting functional recovery. However, there is a lack of frontiers and futures analysis in the study of cell transplantation in TSCI.

Methods: We used CiteSpace, VOSviewer and biblilometrix R package to perform bibliometric analysis on cell transplantation in TSCI from 2013 to 2023. Bibliometric records were extracted from English articles and reviews from the Web of Science core collection.

Results: The bibliometric analysis included 284 papers published in 154 journals by 1,780 authors from 487 institutions in 41 countries and regions. The number of articles published in the past decade has fluctuated slightly, while the number of article citations has steadily increased. Mainland China and the United States are the leading countries and regions in this field, with the National Natural Science Foundation of China being the most funded foundation, and the United States being the country with the most funded articles. The University of Toronto in Canada is a prolific institution. Michael G. Fehlings has published the most articles, and D Michele Basso is the most cited author. Cell transplantation is the most published journal, and the Journal of Neurotrauma is the most cited journal. Cell and tissue engineering and clinical neurology are the basic disciplines in this field, and cutting-edge disciplines include developmental biology, biochemistry and molecular biology, and materials science and multidisciplinary. This study also helps scholars understand the current hotspots and future trends in this field. Marrow stromal cells, glial progenitor, and cell therapy are current research hotspots in this field, while nerve regeneration, cell therapy, and the safety of transplantation of transplantation may be potential research directions in the future.

Conclusion: Cell transplantation after TSCI is receiving increasing attention. Cell therapy is both the frontier and a possible future trend in TSCI research. In addition, glial progenitor and marrow stromal cells are also current research hotspots. Meanwhile, nerve regeneration and safety of transplantation may be potential research directions. These findings will help further deepen research on cell transplantation for TSCI in scientific work.
Identification of candidate genes associated with less-photosensitive anthocyanin phenotype using an EMS mutant (pind) in eggplant (Solanum melongena L.)
Authors: Luo Lei , Molthoff Jos , Li Qiang , Liu Ying , Luo Shuangxia , Li Na , Xuan Shuxin , Wang Yanhua , Shen Shuxing , Bovy Arnaud G. , Zhao Jianjun , Chen Xueping
Published: December 2023

Eggplant (Solanum melongena L.) is a highly nutritious and economically important vegetable crop. However, the fruit peel of eggplant often shows poor coloration owing to low-light intensity during cultivation, especially in the winter. The less-photosensitive varieties produce anthocyanin in low light or even dark conditions, making them valuable breeding materials. Nevertheless, genes responsible for anthocyanin biosynthesis in less-photosensitive eggplant varieties are not characterized. In this study, an EMS mutant, named purple in the dark (pind), was used to identify the key genes responsible for less-photosensitive coloration. Under natural conditions, the peel color and anthocyanin content in pind fruits were similar to that of wildtype ‘14-345’. The bagged pind fruits were light purple, whereas those of ‘14-345’ were white; and the anthocyanin content in the pind fruit peel was significantly higher than that in ‘14-345’. Genetic analysis revealed that the less-photosensitive trait was controlled by a single dominant gene. The candidate gene was mapped on chromosome 10 in the region 7.72 Mb to 11.71 Mb. Thirty-five differentially expressed genes, including 12 structural genes, such as CHS, CHI, F3H, DFR, ANS, and UFGT, and three transcription factors MYB113, GL3, and TTG2, were identified in pind using RNA-seq. Four candidate genes EGP21875 (myb domain protein 113), EGP21950 (unknown protein), EGP21953 (CAAX amino-terminal protease family protein), and EGP21961 (CAAX amino-terminal protease family protein) were identified as putative genes associated with less-photosensitive anthocyanin biosynthesis in pind. These findings may clarify the molecular mechanisms underlying less-photosensitive anthocyanin biosynthesis in eggplant.
Internet-delivered therapist-assisted cognitive behavioral therapy for gambling disorder: a randomized controlled trial
Authors: Mide Mikael , Mattiasson Jessica , Norlin David , Sehlin Helena , Rasmusson Josefine , Ljung Sofia , Lindskog Amanda , Petersson Jonna , Saavedra Fanny , Gordh Anna Söderpalm
Published: December 2023

Objectives

Cognitive behavioral therapy (CBT) is the most promising treatment for gambling disorder (GD) but only 21% of those with problematic gambling seek treatment. CBT over the Internet might be one way to reach a larger population. The aim of this study was to assess the effectiveness of Internet-delivered CBT with therapist guidance compared to an active control treatment.

Methods

Using a single-blinded design, 71 treatment-seeking gamblers (18–75 years) diagnosed with GD were randomized to 8 weeks of Internet-delivered CBT guided by telephone support, or 8 weeks of Internet-delivered motivational enhancement paired with motivational interviewing via telephone (IMI). The primary outcome was gambling symptoms measured at a first face-to-face assessment, baseline (treatment start), every 2 weeks, post-treatment, and 6-month follow-up. Gambling expenditures, time spent gambling, depression, anxiety, cognitive distortions, and quality of life were assessed as secondary outcomes. Analysis was performed on the full analysis sample (n = 60), with intention-to-treat sensitivity analyses (n = 69).

Results

In the CBT group, 80% stayed in treatment until the final week, compared to 67% in IMI. Post-treatment and at 6-month follow-up, no differences were found between CBT and IMI for any outcome measure. An exploratory analysis of the total sample (n = 60) showed a significant effect of time during treatment on gambling symptoms (d, [95% CI] 0.52, [−1.15, 2.02]) and all secondary outcomes except the gambling diary (depression (0.89, [−1.07–2.65]); anxiety (0.69, [−1.20–2.38])); cognitive distortions (0.84, [−0.73–2.29]); quality of life (0.60, [−0.61–1.70])). Post-treatment, there were no clinical gambling symptoms in either group. Some deterioration was seen between post-treatment and 6-month follow-up on gambling symptoms (0.42, [−1.74–2.43]), depression (0.59, [−0.82–1.86]), and anxiety (0.30, [−0.99–1.48]). Additionally, it was observed that the largest reduction in gambling symptoms was between the first assessment and baseline.

Conclusion

Both treatments offered in this study were effective at reducing gambling symptoms. It is also possible that the process of change started before treatment, which gives promise to low-intensity interventions for GD. Additional research is needed as this approach could be both cost-effective and has the potential to reach more patients in need of treatment than is currently possible.

Clinical trial registration:

https://www.isrctn.com/, identifier ISRCTN38692394.
“I was very sad, but not depressed”: phenomenological differences between adjustment disorder and a major depressive episode
Authors: Zapata-Ospina Juan Pablo , Jiménez-Benítez Mercedes , Fierro Marco
Published: December 2023

Introduction

Adjustment disorder (AD) is a diagnosis that must be differentiated from major depressive episode (MDE) because of the therapeutic implications. The aim of this study is to understand the experience of patients who in their lifetime have been diagnosed with AD as well as MDE to establish the characteristics of each disorder.

Methods

A descriptive phenomenological approach was used with in-depth interviews to four patients and the method proposed by Colaizzi to understand the experiences and reach the description of both disorders.

Results

Three women and one man, with advanced schooling were interviewed. The participants emphasized the existence of differences that were grouped in: the attribution made by the individual, the theme of cognitions, the variability in the course, the possibility of mood modulation, the syndrome severity, the presence of hopelessness and the perceived course.

Conclusion

Phenomenological differences were found in the subjective experience of MDE and AD. The MDE would be described as an intense state of generalized shutdown of the subject’s own life, with little response to events, and the AD, as a dynamic reaction attributed to a stressful event, with high variability in the course of symptoms due to the dependence on such event, with the preserved hope that it will end.
The bi-directional relationship between growth stunting and early childhood caries: a rapid review
Authors: Aulia Refine Nissa , Indriyanti Ratna , Setiawan Arlette Suzy
Published: December 2023

Objective

This review aims to determine the two-way relationship between stunting and ECC in developing countries worldwide.

Methods

The procedure in this study was carried out using the Preferred Reporting Items for Systematic Reviews and Meta-Analysis-Rapid Review protocol. Article searches were carried out using databases Cochrane and PubMed. In addition, searches were also carried out using backward and forward snowballing techniques to identify articles that were not detected through database searches.

Results

Nine observational epidemiological articles were found in children aged six months to six years, published in 2015–2020. Five articles discussed the features of ECC in stunted children, and the other five discussed stunting in children with caries in their primary teeth.

Conclusion

Several studies found associations between severe ECC and stunting, with ECC and stunting as both independent and dependent variables, suggesting a bi-directional relationship, also supported by literature on the physiological relationship between oral health and nutrition.
Sleep quality and subjective well-being in healthcare students: examining the role of anxiety and depression
Authors: Zhu Yihong , Meng Runtang , Jiang Chen , Yang Nongnong , Huang Mengyi , Wang Xiaowen , Zou Wenjing , Lou Chen , Xiao Ruohan , Lu Jingjing , Xu Jiale , Jiménez-Correa Ulises , Ma Haiyan , Spruyt Karen , Dzierzewski Joseph M.
Published: December 2023

Objective

Sleep issues, negative emotions, and health conditions are commonly co-occurring, whereas their associations among healthcare students have yet to be elucidated. This study aimed to examine whether anxiety and depression mediate the relationship between sleep quality and subjective well-being in healthcare students.

Methods

A cross-sectional survey was conducted among Chinese healthcare students (N = 348). A battery of paper-and-pencil questionnaires—the Sleep Quality Questionnaire (SQQ), World Health Organization-Five Well-Being Index (WHO-5), and Patient Health Questionnaire-4 (PHQ-4) were applied. Descriptive analysis with means (standard deviations) and counts (proportions), Spearman correlation analysis between the SQQ, WHO-5, and PHQ-4, and mediation analysis via structural equation models were performed.

Results

Correlation analysis revealed statistically significant associations between sleep quality, anxiety and depression, and well-being among healthcare students. Mediation analysis identified that poor sleep quality produced relatively low levels of self-reported well-being, which were entirely attributable to anxiety and depression.

Conclusion

Sleep quality was associated with subjective well-being, and this interrelationship was fully mediated by anxiety and depression. Interventions aimed at promoting sleep quality of healthcare students may contribute to promoting their well-being by reducing anxiety and depression.
Why is the Sea Salty and Does it Matter?
Authors: Stedmon Colin A. , Visser André W.
Published: December 2023

A mouthful of water while swimming in a lake is unpleasant but nothing compared to the same situation during a swim in the ocean. A sudden mouthful seawater leaves you gasping for a glass of water to wash the salty taste from your mouth. But have you ever stopped to consider why the sea is salty? In this article, we will dive into the realm of ocean salinity (salt concentration) and show that there is more to it than you may have thought. Where does the ocean’s salt come from? What is it made of and how is salinity measured? Finally, why should the saltiness of the ocean interest us at all?
The main agroecological structure, a methodology for the collective analysis of the Mediterranean agroecological landscape of San Clemente, Region del Maule, Chile
Authors: Salazar-Rojas Angel , Castro-Huerta Ricardo , Altieri Miguel
Published: December 2023

The simplification of the landscape as a consequence of the decrease in biodiversity and the adoption of monoculture production systems has led to a significant decrease in the provision of ecosystem services in the territory. The conversion of agroecosystems requires the adoption of agroecological techniques, which aim to design the agroecosystem as an integrated part of a vegetation matrix of the landscape, interconnecting the different production systems with the agricultural landscape. In order to measure the degree of connectivity of agroecosystems with the landscape, we used the Main Agroecological Structure (MAS) method, which was applied to 36 small agroecosystems of vegetable, livestock and fruit producers, which generally presented a low degree of connectivity. This allows us to evaluate the potential of these systems for agroecological transition, since being present in a moderately complex agricultural landscape gives important advantages over a more simplified system, allowing these producers to dispense with the use of many energy subsidies. This evaluation allows a first approximation to the quantification of the landscape matrix and will allow a comparison between agroecosystems or an evaluation of the evolution of the MAS over time. It is necessary to complement the MAS by quantifying the ecosystem services that may be associated with it.
Comparative analysis of EZH2, p16 and p53 expression in uterine carcinosarcomas
Authors: Makk Evelin , Bohonyi Noémi , Oszter Angéla , Éles Klára , Tornóczky Tamás , Tóth Arnold , Kálmán Endre , Kovács Krisztina
Published: December 2023

Introduction: The role of p16 and p53 immunohistochemistry in the diagnosis of rare and aggressive uterine carcinosarcoma (UCS) has been well established. However, enhancer of zeste homolog 2 (EZH2), a histone methyltransferase and a member of the polycomb group family is a relatively new biomarker, with limited published data on its significance in this tumor type. The goal of this study was to examine EZH2 expression in UCS and its components, in correlation with morphological features, and p16 and p53 staining patterns.

Methods: Twenty-eight UCSs were included in the study. EZH2, p16 and p53 immunoreactivity were assessed independently by two pathologists in both tumor components (epithelial and mesenchymal). EZH2 and p16 immunostains were scored semiquantitatively: based on the percentage and intensity of tumor cell staining a binary staining index (“high- or low-expressing”) was calculated. The p53 staining pattern was evaluated as wild-type or aberrant (diffuse nuclear, null, or cytoplasmic expression). Statistical tests were used to evaluate the correlation between staining patterns for all three markers and the different tumor components and histotypes.

Results: High EZH2 and p16 expression and aberrant p53 patterns were present in 89.3% 78.6% and 85.7% of the epithelial component and in 78.6%, 62.5% and 82.1% of the mesenchymal component, respectively. Differences among these expression rates were not found to be significant (p > 0.05). Regarding the epithelial component, aberrant p53 pattern was found to be significantly (p = 0.0474) more frequent in the serous (100%) than in endometrioid (66.6%) histotypes. Within the mesenchymal component, p53 null expression pattern occurred significantly (p = 0.0257) more frequently in heterologous sarcoma components (71.4%) compared to the homologous histotype (18.8%).

Conclusion: In conclusion, EZH2, p16 and p53 seem to play a universal role in the pathogenesis of UCS; however, a distinctive pattern of p53 expression appears to exist between the serous and endometrioid carcinoma components and also between the homologous and heterologous sarcoma components.
The Application of a Laser-Printed Miniature Five-Hole Probe in the End-Wall Flow Measurement of a Multistage Axial Compressor
Authors: Ma Shuai , Hu Jun , Wang Xuegao , Ji Jiajia
Published: December 2023

To make measurement of end-wall flow between blade rows in a compact multistage configuration possible, a miniature L-shaped five-hole probe was employed in this paper. This compact tip structure, realized by laser-printing instead of the conventional machining technique, reduces the blockage effect of this intrusive measurement on the flow and ensures high spatial resolution. The zonal method is introduced to extend the usable flow angle range up to 60 degrees. A local least-squares interpolation technique is utilized to acquire flow angle and static/total pressure. In order to improve accuracy for the points located at the sector boundary, the overlap region method is included in the interpolation. Additional test data indicate that the maximum error in flow angle is nearly within 1 degree, and the maximum errors of total pressure and static pressure are 0.56% and 1.9% respectively. The application in a low-speed multistage axial compressor indicates that the zonal method can decrease the number of points exceeding the measurable flow range and is of great significance for the end-wall flow measurement, especially for the near-stall condition. Compared with the traditional method, the proportion of available data for the near-stall state measurement was increased by 18% by using the zonal method.
Aerodynamic Uncertainty Quantification of a Low-Pressure Turbine Cascade by an Adaptive Gaussian Process
Authors: Fu Wenhao , Chen Zeshuai , Luo Jiaqi
Published: December 2023

Stochastic variations of the operation conditions and the resultant variations of the aerodynamic performance in Low-Pressure Turbine (LPT) can often be found. This paper studies the aerodynamic performance impact of the uncertain variations of flow parameters, including inlet total pressure, inlet flow angle, and turbulence intensity for an LPT cascade. Flow simulations by solving the Reynolds-averaged Navier–Stokes equations, the SST turbulence model, and γ−Re˜θt transition model equations are first carried out. Then, a Gaussian process (GP) based on an adaptive sampling technique is introduced. The accuracy of adaptive GP (ADGP) is proven to be high through a function experiment. Using ADGP, the uncertainty propagation models between the performance parameters, including total pressure-loss coefficient, outlet flow angle, Zweifel number, and the uncertain inlet flow parameters, are established. Finally, using the propagation models, uncertainty quantifications of the performance changes are conducted. The results demonstrate that the total pressure-loss coefficient and Zweifel number are sensitive to uncertainties, while the outlet flow angle is almost insensitive. Statistical analysis of the flow field by direct Monte Carlo simulation (MCS) shows that flow transition on the suction side and viscous shear stress are rather sensitive to uncertainties. Moreover, Sobol sensitivity analysis is carried out to specify the influence of each uncertainty on the performance changes in the turbine cascade.
Pearl Millet–Groundnut Cropping Systems for the Sahel
Authors: Maman Nouri , Mason Stephen C.
Published: December 2023

A two-year study of pearl millet–groundnut cropping systems across two fertilizer levels was conducted in Maradi, Niger, in the Sahelian zone of West Africa. The objective of this study was to identify the best cropping system with and without fertilizer application. The experiment was conducted with ten treatment combinations of five pearl millet and groundnut cropping systems (pearl millet and groundnut sole crops, and three pearl millet—groundnut intercrops) and two fertilizer levels. Yields were approximately 300 kg ha−1 higher in the 2022 high rainfall year than in 2021, but the year did not interact with cropping systems or fertilizer application. All the intercropping systems had an LER above 1.0, and land use efficiency increased by 19 to 41%. Fertilizer application increased yields in all cropping systems by 200 to 600 kg ha−1. The government subsidy increased the value-to-cost ratio by 0.5 to 2.5 units and was required for the economic response for pearl millet sole and intercrops in 2022. The groundnut sole cropping system had the greatest economic response to fertilizer application. Based on the risky environment and multiple end uses needed by producers, the intercrop system M-G: 1:3:1 with fertilizer application is the best option to optimize pearl millet and groundnut production.
A Systematic Review of Machine-Learning Solutions in Anaerobic Digestion
Authors: Rutland Harvey , You Jiseon , Liu Haixia , Bull Larry , Reynolds Darren
Published: December 2023

The use of machine learning (ML) in anaerobic digestion (AD) is growing in popularity and improves the interpretation of complex system parameters for better operation and optimisation. This systematic literature review aims to explore how ML is currently employed in AD, with particular attention to the challenges of implementation and the benefits of integrating ML techniques. While both lab and industry-scale datasets have been used for model training, challenges arise from varied system designs and the different monitoring equipment used. Traditional machine-learning techniques, predominantly artificial neural networks (ANN), are the most commonly used but face difficulties in scalability and interpretability. Specifically, models trained on lab-scale data often struggle to generalize to full-scale, real-world operations due to the complexity and variability in bacterial communities and system operations. In practical scenarios, machine learning can be employed in real-time operations for predictive modelling, ensuring system stability is maintained, resulting in improved efficiency of both biogas production and waste treatment processes. Through reviewing the ML techniques employed in wider applied domains, potential future research opportunities in addressing these challenges have been identified.
Role of Telomere Length in Survival of Patients with Idiopathic Pulmonary Fibrosis and Other Interstitial Lung Diseases
Authors: Tesolato Sofía , Vicente-Valor Juan , Jarabo Jose-Ramón , Calatayud Joaquín , Sáiz-Pardo Melchor , Nieto Asunción , Álvaro-Álvarez Dolores , Linares María-Jesús , Fraile Carlos-Alfredo , Hernándo Florentino , Iniesta Pilar , Gómez-Martínez Ana-María
Published: December 2023

Interstitial lung diseases (ILDs) constitute a group of more than 200 disorders, with idiopathic pulmonary fibrosis (IPF) being one of the most frequent. Telomere length (TL) shortening causes loss of function of the lung parenchyma. However, little is known about its role as a prognostic factor in ILD patients. With the aim of investigating the role of TL and telomerase activity in the prognosis of patients affected by ILDs, we analysed lung tissue samples from 61 patients. We measured relative TL and telomerase activity by conventional procedures. Both clinical and molecular parameters were associated with overall survival by the Kaplan–Meier method. Patients with IPF had poorer prognosis than patients with other ILDs (p = 0.034). When patients were classified according to TL, those with shortened telomeres reported lower overall survival (p = 0.085); differences reached statistical significance after excluding ILD patients who developed cancer (p = 0.021). In a Cox regression analysis, TL behaved as a risk-modifying variable for death associated with rheumatic disease (RD) co-occurrence (p = 0.029). Also, in patients without cancer, ferritin was significantly increased in cases with RD and IPF co-occurrence (p = 0.032). In relation to telomerase activity, no significant differences were detected. In conclusion, TL in lung tissue emerges as a prognostic factor in ILD patients. Specifically, in cases with RD and IPF co-occurrence, TL can be considered as a risk-modifying variable for death.
Genetic Susceptibility of HLA Alleles to Non-Steroidal Anti-Inflammatory Drug Hypersensitivity in the Taiwanese Population
Authors: Chang Szu-Ling , Lai Chih-Hung , Lin Guan-Cheng , Chen Yi-Ming , Lee Mei-Hsuan , Hsu Han-Shui , Chen I-Chieh
Published: December 2023

Background: Human leukocyte antigen (HLA) genes are important in many immune processes and contribute to many adverse drug reactions. Whether genetic variations in the HLA region are associated with non-steroid anti-inflammatory drug (NSAID) hypersensitivity remains uncertain. Therefore, the aim of our study was to identify HLA genetic variations in patients with NSAID hypersensitivity in the Taiwanese population. Methods: This hospital-based, retrospective case-control study enrolled 37,156 participants with NSAID exposure from the Taiwan Precision Medicine Initiative (TPMI), who were all genotyped and imputed to fine map HLA typing. Our study assigned 1217 cases to the NSAID allergy group and 12,170 controls to a matched group. Logistic regression analyses were utilized to explore associations between HLA alleles and NSAID hypersensitivity. Results: Overall, 13,387 patients were genotyped for eight major HLA alleles. Allele frequencies were different between the two groups. In the NSAID allergy group, the genotype frequencies of HLA-A*02:01, HLA-A*34:01, and HLA-DQA1*06:01 were found to be markedly elevated compared to the control group, a significance that persisted even after applying the Bonferroni correction. Furthermore, the risk of NSAID allergy demonstrated a significant association with HLA-A*02:01 (OR = 1.29, p < 0.001) and HLA-A*34:01 (OR = 9.90, p = 0.001), in comparison to their respective counterparts. Notably, the genotype frequency of HLA-B*46:01 exhibited a significant increase in the severe allergy group when compared with the mild allergy group. Conclusions: We identified HLA genotypes linked to the onset and severity of NSAID hypersensitivity. Our findings establish a basis for precision prescription in future clinical applications.