bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolution of BIM to DTs: A Paradigm Shift for the Post-Pandemic AECO Industry
Authors: Megahed Naglaa A. , Hassan Asmaa M.
Published: October 2022

The architecture, engineering, construction, and operation (AECO) industry is evolving rapidly. In particular, technological advancements and lessons learned from the COVID-19 pandemic are shaping the industry’s future. Various artificial intelligence (AI), building information modeling (BIM), and Internet of Things (IoT) techniques have contributed to the industry’s modernization by enabling more self-reliable, self-automated, self-learning, time-saving, and cost-effective processes throughout the various life cycle phases of a smart building or city. As a result, the concept of digital twins (DTs) has recently emerged as a potential solution to optimize the AECO sector to achieve the required cyber-physical integration, particularly following the pandemic. Based on a systematic review, the study develops and proposes theoretical models that examine the evolution of DTs in the context of BIM, cutting-edge technologies, platforms, and applications throughout the project’s life cycle phases. This study demonstrates DTs’ high potential as a comprehensive approach to planning, managing, predicting, and optimizing AECO projects that will achieve more Sustainable Development Goals (SDGs). However, while DTs offer many new opportunities, they also pose technical, societal, and operational challenges that must be addressed.
ML-DTD: Machine Learning-Based Drug Target Discovery for the Potential Treatment of COVID-19
Authors: Saha Sovan , Chatterjee Piyali , Halder Anup Kumar , Nasipuri Mita , Basu Subhadip , Plewczynski Dariusz
Published: October 2022

Recent research has highlighted that a large section of druggable protein targets in the Human interactome remains unexplored for various diseases. It might lead to the drug repurposing study and help in the in-silico prediction of new drug-human protein target interactions. The same applies to the current pandemic of COVID-19 disease in global health issues. It is highly desirable to identify potential human drug targets for COVID-19 using a machine learning approach since it saves time and labor compared to traditional experimental methods. Structure-based drug discovery where druggability is determined by molecular docking is only appropriate for the protein whose three-dimensional structures are available. With machine learning algorithms, differentiating relevant features for predicting targets and non-targets can be used for the proteins whose 3-D structures are unavailable. In this research, a Machine Learning-based Drug Target Discovery (ML-DTD) approach is proposed where a machine learning model is initially built up and tested on the curated dataset consisting of COVID-19 human drug targets and non-targets formed by using the Therapeutic Target Database (TTD) and human interactome using several classifiers like XGBBoost Classifier, AdaBoost Classifier, Logistic Regression, Support Vector Classification, Decision Tree Classifier, Random Forest Classifier, Naive Bayes Classifier, and K-Nearest Neighbour Classifier (KNN). In this method, protein features include Gene Set Enrichment Analysis (GSEA) ranking, properties derived from the protein sequence, and encoded protein network centrality-based measures. Among all these, XGBBoost, KNN, and Random Forest models are satisfactory and consistent. This model is further used to predict novel COVID-19 human drug targets, which are further validated by target pathway analysis, the emergence of allied repurposed drugs, and their subsequent docking study.
Systemic and Mucosal Humoral Immune Response Induced by Three Doses of the BNT162b2 SARS-CoV-2 mRNA Vaccines
Authors: Mancuso Roberta , Agostini Simone , Citterio Lorenzo Agostino , Chiarini Debora , Santangelo Maria Antonia , Clerici Mario
Published: October 2022

BNT162b2 (BioNTech/Pfizer) was the first SARS-CoV-2 mRNA vaccine approved by the European Medicines Agency. We monitored the long-term humoral responses of healthcare workers (HCWs) who received three vaccine doses. A total of 59 healthcare workers were studied: 47 were never SARS-CoV-2-infected (naïve-HCWs), and 12 (infected-HCWs) recovered from COVID-19 before the first vaccine. Serum and saliva were collected at baseline (before the first dose), just before the second dose, 1, 3, 6, and 9 months after the second dose, and 10 days after the third vaccine. SARS-CoV-2-specific IgG and IgA were evaluated in serum and saliva, respectively, and the presence of neutralizing antibodies (NAb) was analyzed in serum. SARS-CoV-2-specific IgG peaked one month after the second vaccine in naïve-HCWs but right before this timepoint in infected-HCWs. IgG titers significantly decreased during follow-up and at month 9 were still detectable in 50% of naïve-HCWs and 90% of infected-HCWs. NAb were significantly decreased 6 months after the second vaccine in naïve-HCWs and 9 months after this dose in infected-HCWs. Salivary SARS-CoV-2-specific IgA titers were significantly higher in infected-HCWs and were undetectable 9 months after the second vaccine in 43% of the naïve-HCWs alone. The third vaccine greatly increased humoral IgG and mucosal IgA in both groups. Two BNT162b2 doses induced strong systemic and humoral immune responses; to note, these responses weakened over time, although they are more prolonged in individuals who had recovered from COVID-19. The third vaccine dose quickly boosts systemic and mucosal humoral responses.
A Case Report: Multifocal Necrotizing Encephalitis and Myocarditis after BNT162b2 mRNA Vaccination against COVID-19
Authors: Mörz Michael
Published: October 2022

The current report presents the case of a 76-year-old man with Parkinson’s disease (PD) who died three weeks after receiving his third COVID-19 vaccination. The patient was first vaccinated in May 2021 with the ChAdOx1 nCov-19 vector vaccine, followed by two doses of the BNT162b2 mRNA vaccine in July and December 2021. The family of the deceased requested an autopsy due to ambiguous clinical signs before death. PD was confirmed by post-mortem examinations. Furthermore, signs of aspiration pneumonia and systemic arteriosclerosis were evident. However, histopathological analyses of the brain uncovered previously unsuspected findings, including acute vasculitis (predominantly lymphocytic) as well as multifocal necrotizing encephalitis of unknown etiology with pronounced inflammation including glial and lymphocytic reaction. In the heart, signs of chronic cardiomyopathy as well as mild acute lympho-histiocytic myocarditis and vasculitis were present. Although there was no history of COVID-19 for this patient, immunohistochemistry for SARS-CoV-2 antigens (spike and nucleocapsid proteins) was performed. Surprisingly, only spike protein but no nucleocapsid protein could be detected within the foci of inflammation in both the brain and the heart, particularly in the endothelial cells of small blood vessels. Since no nucleocapsid protein could be detected, the presence of spike protein must be ascribed to vaccination rather than to viral infection. The findings corroborate previous reports of encephalitis and myocarditis caused by gene-based COVID-19 vaccines.
A Vaccine with Multiple Receptor-Binding Domain Subunit Mutations Induces Broad-Spectrum Immune Response against SARS-CoV-2 Variants of Concern
Authors: Hou Xu-Chen , Xu Hui-Fang , Liu Yang , Sun Peng , Ding Lin-Wei , Yue Jun-Jie , Wang Tian-Tian , Gong Xin , Wu Jun , Liu Bo
Published: October 2022

With the emergence of more variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and the immune evasion of these variants from existing vaccines, the development of broad-spectrum vaccines is urgently needed. In this study, we designed a novel SARS-CoV-2 receptor-binding domain (RBD) subunit (RBD5m) by integrating five important mutations from SARS-CoV-2 variants of concern (VOCs). The neutralization activities of antibodies induced by the RBD5m candidate vaccine are more balanced and effective for neutralizing different SARS-CoV-2 VOCs in comparison with those induced by the SARS-CoV-2 prototype strain RBD. Our results suggest that the RBD5m vaccine is a good broad-spectrum vaccine candidate able to prevent disease from several different SARS-CoV-2 VOCs.
Vaccination Coverage among Immunocompromised Patients in a Large Health Maintenance Organization: Findings from a Novel Computerized Registry
Authors: Shapiro Ben David Shirley , Goren Iris , Mourad Vered , Cahan Amos
Published: October 2022

Immune-compromised patients (IPs) are at high risk for infections, some of which are preventable by vaccines. Specific vaccines are recommended for IP; however, the vaccination rate is suboptimal. The aim of this study is to describe the development of an IP registry and to assess vaccination rates in this population. A population-based registry of IPs was developed using an automated extraction of patient electronic health-record data in Maccabi Healthcare Services (MHS), an Israeli health maintenance organization serving over 2.4 million members. Included in the registry were patients receiving immunosuppressive therapy (IT); patients living with HIV (PLWH); solid organ and bone marrow transplant recipients (TR); patients with advanced kidney disease (AKD), and asplenic patients. We evaluated the full schedule for each vaccine’s uptake rates for influenza, pneumococcal, meningococcal, and hepatitis B. On 1 October 2019, 32,637 adult immune-compromised patients were identified by the registry. Of them, 1647 were PLWH; 2354 were asplenic; 5317 had AKD; 23,216 were on IT; and 1824 were TR. Their mean age was 57 and 52.4% were females. The crude rate of immune compromise among adult MHS members was 2%. Vaccine coverage rate was overall low for PCV13, with only 11.9% of all IPs in the registry having received one dose. Influenza and PPV23 vaccination rates were higher (45% and 39.4%, respectively). Only 5.3% of all IPs received all three vaccines. Overall, low vaccination coverage was found among IPs. Our registry can serve to identify target-patient populations for interventions and monitor their effectiveness.
The Assessment of the Reliability and Validity of the Polish Version of the Adult Vaccine Hesitancy Scale (PL-aVHS) in the Context of Attitudes toward COVID-19 Vaccination
Authors: Duplaga Mariusz , Zwierczyk Urszula , Kowalska-Duplaga Kinga
Published: October 2022

Vaccine hesitancy has become a pivotal consideration in assessing society’s readiness to accept recommended vaccination programs. The role of vaccination as a preventive measure during great epidemic challenges cannot be overestimated. On the other hand, the overwhelming flow of misinformation and attitudes resulting from denialism may have a profoundly harmful effect on the acceptance of preventive interventions. The adult Vaccine Hesitancy Scale (aVHS) is a result of efforts to develop a tool that will be relevant to the views about vaccination in the general adult population. It was derived from the Vaccine Hesitancy Scale (VHS), initially developed by researchers attempting to assess the opinions and attitudes of parents. This study’s main aim was to determine the reliability and validity of the Polish version of aVHS (PL-aVHS). We have also analyzed whether the scale can feasibly predict the COVID-19 vaccination status of respondents. The analysis was performed on data originating from a computer-based web-interviewing (CAWI) survey of 2008 adult Internet users. It included the analysis of internal consistency, test-retest reliability, and hypotheses testing. Exploratory (EFA) and confirmatory factor analyses (CFA) were performed on the subsets generated by randomly splitting the initial survey data. We have found that the scale has excellent internal consistency (Cronbach α = 0.935), acceptable levels of inter-item bivariate correlations, and good test–retest reliability (interclass correlation coefficient, ICC = 0.843). The EFA revealed that the tool has a two-factor latent structure; however, similar loadings of item 10 to both factors spoke for its exclusion from the model. Two extracted factors were responsible for 68.90% of the variance after rotation based on the maximum likelihood method. The CFA showed that the best fit of the model to measurement data was obtained for the two-factor model after excluding item 10. All seven fit indexes calculated in the analysis suggested at least an acceptable fit. In conclusion, the assessment of the PL-aVHS revealed good reliability and validity of the instrument. Furthermore, we have obtained similar EFA results as reported for the English version of the tool. Finally, to our knowledge, it is one of a few tools available in Polish for the measurement of vaccine-related attitudes.
Transient Expression of Flavivirus Structural Proteins in Nicotiana benthamiana
Authors: Asghar Naveed , Melik Wessam , Paulsen Katrine M. , Pedersen Bendikte N. , Bø-Granquist Erik G. , Vikse Rose , Stuen Snorre , Andersson Sören , Strid Åke , Andreassen Åshild K. , Johansson Magnus
Published: October 2022

Flaviviruses are a threat to public health and can cause major disease outbreaks. Tick-borne encephalitis (TBE) is caused by a flavivirus, and it is one of the most important causes of viral encephalitis in Europe and is on the rise in Sweden. As there is no antiviral treatment available, vaccination remains the best protective measure against TBE. Currently available TBE vaccines are based on formalin-inactivated virus produced in cell culture. These vaccines must be delivered by intramuscular injection, have a burdensome immunization schedule, and may exhibit vaccine failure in certain populations. This project aimed to develop an edible TBE vaccine to trigger a stronger immune response through oral delivery of viral antigens to mucosal surfaces. We demonstrated successful expression and post-translational processing of flavivirus structural proteins which then self-assembled to form virus-like particles in Nicotiana benthamiana. We performed oral toxicity tests in mice using various plant species as potential bioreactors and evaluated the immunogenicity of the resulting edible vaccine candidate. Mice immunized with the edible vaccine candidate did not survive challenge with TBE virus. Interestingly, immunization of female mice with a commercial TBE vaccine can protect their offspring against TBE virus infection.
Core Proteomics and Immunoinformatic Approaches to Design a Multiepitope Reverse Vaccine Candidate against Chagas Disease
Authors: Islam Sk Injamamul , Sanjida Saloa , Ahmed Sheikh Sunzid , Almehmadi Mazen , Allahyani Mamdouh , Aljuaid Abdulelah , Alsaiari Ahad Amer , Halawi Mustafa
Published: October 2022

Chagas disease is a tropical ailment indigenous to South America and caused by the protozoan parasite Trypanosoma cruzi, which has serious health consequences globally. Insect vectors transmit the parasite and, due to the lack of vaccine availability and limited treatment options, we implemented an integrated core proteomics analysis to design a reverse vaccine candidate based on immune epitopes for disease control. Firstly, T. cruzi core proteomics was used to identify immunodominant epitopes. Therefore, we designed the vaccine sequence to be non-allergic, antigenic, immunogenic, and to have better solubility. After predicting the tertiary structure, docking and molecular dynamics simulation (MDS) were performed with TLR4, MHC-I, and MHC-II receptors to discover the binding affinities. The final vaccine design demonstrated significant hydrogen bond interactions upon docking with TLR4, MHC-I, and MHC-II receptors. This indicated the efficacy of the vaccine candidate. A server-based immune simulation approach was generated to predict the efficacy. Significant structural compactness and binding stability were found based on MDS. Finally, by optimizing codons on Escherichia coli K12, a high GC content and CAI value were obtained, which were then incorporated into the cloning vector pET2+ (a). Thus, the developed vaccine sequence may be a viable therapy option for Chagas disease.
Humoral Response to Hepatitis B and COVID-19 Vaccine among Maintenance Hemodialysis Patients
Authors: Nacasch Naomi , Cohen-Hagai Keren , Tayar Nurit , Levian Avraham , Rashid Gloria , Benchetrit Sydney , Neumark Eran , Wand Ori , Hod Tammy , Rosman Yossi , Shashar Moshe , Grupper Ayelet , Shitrit Pnina
Published: October 2022

Maintenance hemodialysis (MHD) patients have impaired immunological responses to pathogens and vaccines. In this study, we compared the humoral response to HBV and COVID-19 vaccines in a cohort of MHD patients. Demographic and clinical characteristics of vaccine responders and non-responders were also compared, and the association between the humoral responses to both vaccines was evaluated. The cohort included 94 MHD patients who were vaccinated at least once for HBV and twice for COVID-19. Among the 94 patients, 28 (29.8%) did not develop protective titers to HBV. Hypertension, coronary heart disease, and heart failure were more common in non-responders. Among MHD patients, 85% had positive IgG anti-spike SARS-CoV-2 levels 6 months after two doses of BNT162b2 (Pfizer/Biotech) vaccine. Age and immunosuppressive therapy were the main predictors of humoral response to COVID-19 vaccine. We did not find any association between non-responders to HBV and non-responders to COVID-19 vaccine. There was no difference in IgG anti-spike titers between HBV responders and non-responders (505 ± 644 vs. 504 ± 781, p = 0.9) Our results suggest that reduced humoral response to hepatitis B is not associated with reduced response to COVID-19 vaccine. Different risk-factors were associated with poor immune response to HBV and to COVID-19 vaccines.
Immune Persistence against SARS-CoV-2 after Primary and Booster Immunization in Humans: A Large-Scale Prospective Cohort Study
Authors: Li Juan , Xie Hui , Chen Weixin , Chen Meng , Bai Shuang , Zhao Wei , Zhou Tao , Gao Pei , Zhang Lichi , Wang Quanyi , Pang Xinghuo , Huang Chun , Wu Jiang
Published: October 2022

Amid the ongoing global COVID-19 pandemic, limited literature exists on immune persistence after primary immunization and the immunogenic features of booster vaccines administered at different time intervals. Therefore, this study aimed to determine the immune attenuation of neutralizing antibodies against the SARS-CoV-2 wild-type strain, and Delta and Omicron variants 12 months after the primary administration of the COVID-19 inactivated vaccine and evaluate the immune response after a booster administration at different time intervals. A total of 514 individuals were followed up after primary immunization and were vaccinated with a booster. Neutralizing antibodies against the wild-type strain and Delta and Omicron variant spike proteins were measured using pseudovirus neutralization assays. The geometric mean titers (GMTs) after the primary and booster immunizations were 12.09 and 61.48 for the wild-type strain, 11.67 and 40.33 for the Delta variant, and 8.51 and 29.31 for the Omicron variant, respectively. The GMTs against the wild-type strain declined gradually during the 12 months after the primary immunization, and were lower against the two variants. After implementing a booster immunization with a 6 month interval, the GMTs against the wild-type strain were higher than those obtained beyond the 7 month interval; however, the GMTs against the two variants were not statistically different across 3–12 month intervals. Overall, SARS-CoV-2 variants showed remarkable declines in immune persistence, especially against the Omicron variant. The booster administration interval could be shortened to 3 months in endemic areas of the Omicron variant, whereas an appropriate prolonging of the booster administration interval did not affect the booster immunization effect.
There Is No Evidence That Inactivated COVID-19 Vaccines Increase Risks of Uveitis Flare
Authors: Song Hang , Zhao Chan , Zhang Meifen
Published: October 2022

This is a retrospective study to investigate the impact of inactivated Coronavirus disease-2019 (COVID-19) vaccination on uveitis flare in patients with uveitis. Sixty patients that were regularly followed up for uveitis for at least two months after the last dose of inactivated COVID-19 vaccines were included in the vaccination group. Sixty patients with comparable characteristics of uveitis who had not received the COVID-19 vaccines were included in the control group. Uveitis flare within 30 days and 60 days after the vaccination in the vaccination group, or after a randomly selected date in the control group, were statistically compared. The flare rate was 16.7% (30 days) and 23.3% (60 days) in the vaccination group, while it was 13.3% (30 days) and 25% (15/60) in the control group. There was no statistical difference in the flare rate of uveitis between the two groups (p = 0.471 for 30 days, p = 0.347 for 60 days). Inactivated COVID-19 vaccination appeared not to increase the flare rate in patients with uveitis. Ophthalmologists should give proper and individualized recommendations based on the overall conditions of patients.
Using MicroRNA Arrays as a Tool to Evaluate COVID-19 Vaccine Efficacy
Authors: Lin Yen-Pin , Hsieh Yi-Shan , Cheng Mei-Hsiu , Shen Ching-Fen , Shen Ching-Ju , Cheng Chao-Min
Published: October 2022

In order to solve COVID-19 pandemic, the entire world has invested considerable manpower to develop various new vaccines to temporarily alleviate the disaster caused by the epidemic. In addition to the development of vaccines, we need to also develop effective assessment methods to confirm vaccines’ efficacy and maximize the benefits that vaccines can bring. In addition to common evaluation methods, vaccine-specific and temporal expression of microRNAs have been shown to be related to vaccine efficacy or vaccine-associated diseases. In this article, we have introduced a microRNA-array-based approach, which could be potentially used for evaluating COVID-19 vaccine efficacy, specifically for pregnant women. As the mRNA in mRNA vaccines is decomposed by host cells within a few days, it is considered more suitable for pregnant women to utilize the method of vaccination during pregnancy. Moreover, pregnant women belong to a high-risk group for COVID-19, and there is currently no appropriate vaccine to newborns. Therefore, it’s important to find improved tools for evaluation of vaccine efficacy in response to the current situation caused by COVID-19.
Points to Consider in the Development and Information Provision of Vaccines for Vaccination during Pregnancy: A Survey
Authors: Nomura Yumiko , Oohashi Yuusuke , Shikano Mayumi
Published: October 2022

This report surveyed vaccination decisions during pregnancy based on the package inserts of vaccines approved in Japan, the USA, and Europe. Furthermore, it evaluates vaccination decision-making factors based on the characteristics of the target infections and the modality of the vaccines. Live vaccines known to cause fetal abnormalities are contraindicated for pregnant women, whereas vaccines for life-threatening infectious diseases are authorized for administration during pregnancy when the need is recognized, even for live vaccines. We compared the World Health Organization and European Medicines Agency guidelines on the development of vaccines for pregnant women and surveyed the details of the studies to collect information on SARS-CoV-2 vaccination during pregnancy. In compliance with the guidelines, for all SARS-CoV-2 vaccines, non-clinical reproductive and developmental toxicity studies and clinical trials including non-pregnant women of childbearing age were conducted prior to the vaccination of pregnant women. For all vaccines, information from registries on vaccination during pregnancy are used for post-marketing surveillance. While it is desirable to vaccinate women before pregnancy through planned immunization, whenever possible, pandemics such as H1N1 influenza and COVID-19 may require vaccination even during pregnancy. Necessary and sufficient studies for the decision of vaccination during pregnancy should be carried out promptly.
Dysautonomia in Children with Post-Acute Sequelae of Coronavirus 2019 Disease and/or Vaccination
Authors: Buchhorn Reiner
Published: October 2022

Long-term health problems such as fatigue, palpitations, syncope, and dizziness are well-known in patients after COVID-19 (post-acute sequelae of coronavirus (PASC)). More recently, comparable problems have been noticed after the SARS-CoV-2 vaccination (post-VAC). The pathophysiology of these problems is not well-understood. Methods: In 38 children and young adults, we tested if these health problems were related to dysautonomia in an active standing test (Group 1: 19 patients after COVID-19; Group 2: 12 patients with a breakthrough infection despite a vaccination; and Group 3: 7 patients after a vaccination without COVID-19). The data were compared with a control group of 47 healthy age-matched patients, as recently published. Results: All patients had a normal left ventricular function as measured by echocardiography. Significantly elevated diastolic blood pressure in all patient groups indicated a regulatory cardiovascular problem. Compared with the healthy control group, the patient groups showed significantly elevated heart rates whilst lying and standing, with significantly higher heart rate increases. The stress index was significantly enhanced in all patient groups whilst lying and standing. Significantly decreased pNN20 values, mostly whilst standing, indicated a lower vagus activity in all patient groups. The respiratory rates were significantly elevated in Groups 1 and 2. Conclusion: The uniform increase in the heart rates and stress indices, together with low pNN20 values, indicated dysautonomia in children with health problems after COVID-19 disease and/or vaccination. A total of 8 patients fulfilled the criteria of postural orthostatic tachycardia syndrome and 9 patients of an inappropriate sinus tachycardia, who were successfully treated with omega-3 fatty acid supplementation and pharmacotherapy.
Regulation of Extracellular Vesicle-Mediated Immune Responses against Antigen-Specific Presentation
Authors: Matsuzaka Yasunari , Yashiro Ryu
Published: October 2022

Extracellular vesicles (EVs) produced by various immune cells, including B and T cells, macrophages, dendritic cells (DCs), natural killer (NK) cells, and mast cells, mediate intercellular communication and have attracted much attention owing to the novel delivery system of molecules in vivo. DCs are among the most active exosome-secreting cells of the immune system. EVs produced by cancer cells contain cancer antigens; therefore, the development of vaccine therapy that does not require the identification of cancer antigens using cancer-cell-derived EVs may have significant clinical implications. In this review, we summarise the molecular mechanisms underlying EV-based immune responses and their therapeutic effects on tumour vaccination.
International Society of University Colon and Rectal Surgeons survey of surgeons’ preference on rectal cancer treatment
Authors: Dulskas Audrius , Caushaj Philip F. , Grigoravicius Domas , Zheng Liu , Fortunato Richard , Nunoo-Mensah Joseph W. , Samalavicius Narimantas E.
Published: October 2022

Purpose: Rectal cancer treatment has a wide range of possible approaches from radical extirpative surgery to nonoperative watchful waiting following chemoradiotherapy, with or without, additional chemotherapy. Our goal was to assess the personal opinion of active practicing surgeons on rectal cancer treatment if he/she was the patient.Methods: A panel of the International Society of University Colon and Rectal Surgeons (ISUCRS) selected 10 questions that were included in a questionnaire that included other items including demographics. The questionnaire was distributed electronically to ISUCRS fellows and other surgeons included in our database and remained open from April 16 to 28, 2020.Results: One hundred sixty-three specialists completed the survey. The majority of surgeons (n=65, 39.9%) chose the minimally invasive (laparoscopic) surgery for their personal treatment of rectal cancer. For low-lying rectal cancer T1 and T2, the treatment choice was standard chemoradiation+local excision (n=60, 36.8%) followed by local excision±chemoradiotherapy if needed (n=55, 33.7%). In regards to locally advanced low rectal cancer T3 or greater, the preference of the responders was for laparoscopic surgery (n=65, 39.9%). We found a statistically significant relationship between surgeons’ age and their preference for minimally invasive techniques demonstrating an age-based bias on senior surgeons’ inclination toward open approach.Conclusion: Our survey reveals an age-based preference by surgeons for minimally invasive surgical techniques as well as organ-preserving techniques for personal treatment of treating rectal cancer. Only 1/4 of specialists do adhere to the international guidelines for treating early rectal cancer.
The specifics of using a variable approach to accounting for a company's expenses for an IPO in modern conditions
Authors: Mazhara Evgenii N. , Sharapova Anastasiya I.
Published: October 2022

A variant approach to the possibility of providing for the reflection of the costs of an organization (company) on an IPO (from the English - Initial Public Offering) through the formation of deferred costs is substantiated. An alternative possibility is proposed for using this approach by joint-stock companies to reflect the costs of an IPO in a linear way, taking into account the life cycle of the company. Such an approach can help improve investment policy, increase the level of capitalization and financial stability of companies against the backdrop of falling incomes and non-decreasing costs. The implementation of the approach will require amendments to the Accounting Regulation "Organization's Expenses" (PBU 10/99) in terms of adjusting the methods for estimating the cost, which, according to the authors, is not only justified, but also necessary for domestic companies whose shares are listed on the Moscow Exchange.
Predicting the riskiness of investing in oil company stocks using artificial neural networks
Authors: Yarosh Anton A. , Rakhmatullina Yuliya A.
Published: October 2022

This article considers the problem of forecasting stock prices using the example of the largest oil companies in Russia (Rosneft, Lukoil, Gazpromneft and Surgutneftegaz) using artificial neural networks, and also analyzes the profitability of an investment portfolio formed from ordinary shares of the four largest oil companies in Russia in equal shares and with optimal their value determined in the course of solving the direct problem according to the G. Markowitz model using predictive values.
Estimation of the value of the client capital of a higher educational institution (on the example of the Novosibirsk State University of Economics and Management)
Authors: Lomonosov Aleksandr V.
Published: October 2022

The article examines the views of researchers on the client capital of a higher educational institution. The author formulated the following theses: client capital is one of the elements of the structure of intellectual capital, the share of which depends on the field of activity under consideration; client capital is a special type of intangible asset of an organization that affects its value; client capital itself is heterogeneous, structural elements can be distinguished in it; for a certain kind of organizations, an anchor element can be distinguished, which characterizes client capital; for higher education institutions, the anchor is student client capital. Six factors influencing the financial indicator of the university's client capital are identified: personnel; infrastructure, educational processes; the price of educational services; non-enrolled applicants; availability of budget places (students of the budget form of education); loyalty of existing students. The author's structure of the university's client capital is substantiated: the main student client capital, loyalty capital, applicant's capital. The article presents the author's methodology for assessing the value of the client capital of a higher educational institution. The cost of the client capital of the Novosibirsk State University of Economics and Management "NINH" was estimated in the context of the structure of client capital and training levels. Based on the financial indicator, the structure of educational program portfolios is presented: strategic, investment, conservative.
Improving the financial literacy of the Russian population through the development of financial advisory institutions
Authors: Musabirov Albert V. , Chuvilin Denis V.
Published: October 2022

The article discusses the possibilities of developing financial advisory institutions in the Russian Federation as a basis for improving the level of financial literacy of the population. Special attention is paid to the study of foreign experience in financial consulting and current trends in this area. In the course of the research, an analysis of the existing state programs in this area in Russia, as well as the main tools and products of financial consulting, was carried out. According to the results, three main directions for the development of financial consulting in Russia are proposed, with the help of which it is planned to increase the level of financial literacy of its citizens.
On the issue of the use of risk neutralization tools in financial market segments
Authors: Antsibor Inga A. , Osipova Natalia I.
Published: October 2022

The financial market exists in the interests of society as a whole, contributes to meeting the needs of citizens, preserving and increasing well-being, stimulating the economic development of the state by accumulating free funds and converting them into investment capital, with minimal risks. Historical observations show the constant uneven growth of risks in all segments of the financial market, which causes difficulties in minimizing them, especially in conditions of geopolitical tension through the imposition of all kinds of economic sanctions. The article provides an overview of existing classical and innovative tools to reduce the vulnerability of financial market sectors from the loss of their liquidity and stability.
Making an investment decision in the cryptocurrency market
Authors: Popova Tamara A. , Vasilyeva Victoria I.
Published: October 2022

This article is devoted to the formation of a methodological basis for assessing the investment attractiveness of cryptocurrencies. The paper studies the main investment strategies with cryptocurrencies, and developed a methodological approach to making an investment decision in the crypto-currency market, which includes an assessment of the investment attractiveness of a digital financial asset. The scientific article presents an assessment of the investment attractiveness of the two most popular cryptocurrencies - Bitcoin and Ethereum.
Influence of the digital space on suicidal behavior of adolescents
Authors: Lubenets Iryna , Kulyk Oleksandr , Lisnychenko Lillia , Naumova Iryna , Chabaiovskyi Taras
Published: October 2022

With the Internet now firmly established as the main medium of communication in today’s world, studying the effect of its various aspects on the behavior of minors is now more relevant than ever.

This article provides arguments in favor of the need to study the phenomenon of cybersuicide among adolescents in light of the rising number of suicides among children in many countries in recent years, including Ukraine.

The aim of this article is to study the role of the digital space, namely the Internet, in the reinforcement of suicidal ideation and intentions among children and, ultimately, in driving them to suicide.

To achieve this goal, a number of general and special research methods for understanding social realities were used, to ensure objectivity and accuracy of obtained data, which was all the more important given the nature of the subject.

The dangers of the pre-suicidal state (pre-suicide) were examined, including from a medical perspective. Particular attention was paid to behavioral tendencies common among adolescents.

The authors arrived at the conclusion that the digital space can both trigger suicidal thoughts and intentions in adolescents with its content and facilitate their committing suicide through “support” or even encouragement from online friends.

The authors stress that related content children post on social media can help discover whether they have been having suicidal ideation. Arguments are given in favor of the need for parents, teachers, and psychologists to monitor said content to be able to provide timely psychological help, including via the digital space.
Termination of pre-trial investigation due to a serious illness of the suspect (accused) in the criminal procedure of Ukraine and some European states
Authors: Bobechko Nazar , Maksymyshyn Nataliya
Published: October 2022

The aim of the article is to study the legal regulations, doctrinal approaches to the understanding of mental disorder or another serious disease of the suspect (accused) as a reason for stopping the pre-trial investigation in the criminal procedural law of European countries, and also the development and justification of the proposal, directed for the improvement of the regulation of such reasons in the criminal procedural law of Ukraine. The methodological grounds of the research constitute general scientific and special legal methods, in particular dialectical, method of analysis, method of generalization, structural and functional method, hermeneutical method, dogmatic method, comparative legal method. We analyze one of the reasons for stopping the pre-trial investigation – mental disorder or another serious disease of the suspect (accused). Analyzing the corresponding legal acts of the CPC of Ukraine and European countries, the views of researchers, we provide our views on the questions of the research topic, and give suggestions on the improvement of the criminal procedural law of Ukraine. The signs of mental disorder of the suspect (accused) have been clarified, the criteria of the serious somatic symptom disorder as a reason for stopping the pre-trial investigation have been singled out. A new version of P. 1 Ch. 1 Art. 280 of the CPC of Ukraine has been proposed.
Learning english through YouTube as a self-development factor for future officers
Authors: Kamentsev Denys , Havryshkiv Oksana , Kukharska Liliia , Romashko Olha , Baybakova Inesa
Published: October 2022

The aim of the article was to assess the effectiveness of learning English through YouTube as a factor in improving the future officers’ language skills. The study involved the following methods: survey, pedagogical experiment, Score-Rating System of Performance Control; Scale of Assessing the Need to Achieve the Goal by Yu. M. Orlov; Adapted Method of T. I. Ilina — Examining Motivation to Study in a higher educational institution (HEI); Diagnosis of the Level of Reflexivity Development by A. V. Karpov. The dynamics of change in the level of foreign language competence is very insignificant for students in the traditional form of education (control group), and it applies only to levels A1 (-8%) and A2 (+8%), that is, the lowest of the represented ones. Learning through the proposed model helps increase student involvement in foreign language learning, which is reflected in the increased number of completed assignments. The quality of education is growing, which is reflected in the increased level of student performance.
Introducing the latest teaching and educational development practices in mathematics: the experience of EU countries
Authors: Kolomiiets Alona , Olefir Olena , Urum Galyna , Tiutiunnyk Oksana , Dobraniuk Yurii
Published: October 2022

The purpose of this work was to investigate the qualitative implementation and the possibility of use in the educational context of Ukraine. For this work, the author invited five groups (a total of 169 students of different genders). The second was a conversation with the teachers about the atmosphere in the classroom, the difficulty of the learning process, and the results. The study showed the weakness and small effectiveness of the old teaching methods (control group) and elementary explanatory online meetings.
Strategies for economic development: the Ukrainian case
Authors: Okhrimenko Oksana , Chynchyk Anatolii , Dergach Anna , Bannikova Kateryna , Nesterenko Olena
Published: October 2022

The article studies the peculiarities of economic strategies of developed countries of the world and carries out a comparative analysis of the strategic goals of Ukraine and Poland. Based on correlation and graphical analysis, it is proved that the basis of economic growth of Poland, which had actually the same starting conditions as Ukraine after the collapse of the USSR, is the economic ideology, which provides for the development, stimulation, and support of the processing industry. In particular, the study showed that it is the deindustrialization of the Ukrainian economy and the reduction of processing industry products in the structure of Ukrainian exports leads to a slowdown in the growth rate of absolute GDP and GDP per capita, in Poland, there are cardinally opposite trends. The formation of economic strategies within the framework of the ideology of stimulation of the processing industry adapts macroeconomic policy to meet such goals by increasing capital expenditures, implementation of state-targeted development programs, debt financing. Besides, an important strategic principle of Ukraine's economic strategies should be the principle of increasing capital expenditures of the state budget, at the expense of deficit and debt financing of target programs of the economic market.
European practices of inclusive education (experience for Ukraine)
Authors: Lemeshchuk Maryna , Pisnyak Valentina , Berezan Valentyna , Stokolos-Voronchuk Oksana , Yurystovska Natalia
Published: October 2022

In the era of globalization, there is a process of democratization and openness of society. The value of human beings, their dignity, and their lives are being redefined and given new meaning. Race, gender, gender, social stratum, physical and mental capabilities are no longer “criteria” for being in society. Everyone has the right to exercise his or her rights. Everyone has the right to education, medicine, life, etc. Ukraine is gradually moving towards Europe and over the past five years has been actively implementing a program of inclusive education. Inclusive education is a system of educational activities aimed at overcoming discrimination and exclusion of students with physical and psychological disabilities. This system of education has become in opposition to the boarding school system, where students are cut off from society. For five years, Ukraine has been actively creating inclusive classes and introducing various teaching methods. We can consider Europe as an example as a defender of democracy and human dignity. Therefore, the purpose of our work is to study the European practices of inclusive education in Ukraine. For the purpose we used the following methods: observation (throughout the study), interviews with all subjects of the learning process, inductive method, testing to check knowledge. Since the essence of inclusive education is not only the acquisition of knowledge but also comfortable growth in society, we want to pay special attention to this aspect. The results of the study showed that a special role is played by individual development of tasks for students, allowing to involve children even with psychophysiological problems. Also, a special role is played by parents and a teacher's assistant (for example, in Italy), the game form of learning, the change of activities after 10-20 minutes, group work, etc. The novelty of the study lies precisely in the analysis of the implementation and evaluation of European practices in Ukraine. The results of the study can be used in adjusting educational programs of inclusive education, communication of all subjects of training and for their qualitative implementation, as well as acquiring the importance of the role of assistant teacher.
ANALISIS TINGKAT KEPUASAN KERJA KARYAWAN PABRIK PENGOLAHAN RSS DI PT. DS
Authors: Ilmannafian Adzani Ghani , Hasanah Erni
Published: October 2022

Sumber daya manusia adalah aset utama suatu perusahaan dalam usaha pencapaian tujuannya. Karyawan yang berkualitas dapat mendorong perusahaan untuk terus bertahan menghadapi persaingan, bahkan mengembangkan usaha. Bagi manajemen kepuasan kerja haruslah menjadi fokus utama dalam merencanakan dan menyusun kebijakan yang berkaitan dengan manajemen sumber daya manusia. Adanya manajemen sumber daya manusia terhadap tingkat kepuasan kerja karyawan pabrik PT. DS diharapkan dapat memberikan gambaran dan solusi bagi perusahaan dalam upaya meningkatkan kepuasan kerja karyawan nya. Penelitian ini bertujuan untuk menganalisis tingkat kepuasan kerja karyawan pabrik pengolahan RSS di PT DS. Penelitian ini adalah penelitian deskriptif dengan metode survei. Data diperoleh dengan melakukan penyebaran kuesioner untuk memperoleh tanggapan responden mengenai variabel-variabel yang diteliti yaitu, hubungan atasan-bawahan, hubungan rekan kerja, kondisi tempat kerja, isi pekerjaan dan penghargaan/rewards. Hasil penelitian menunjukkan bahwa Tingkat kepuasan kerja karyawan pabrik pengolahan RSS PT. DS secara umum sudah puas dari variabel hubungan atasan bawahan, hubungan rekan kerja dan isi pekerjaan, namun pada variabel kondisi tempat kerja dan imbalan/rewards masih belum puas.