bluuebunny/crossref_metadata_2025 huggingface dataset:
O EMPREENDEDOR DE SI E A EDUCAÇÃO
Authors: Ricardo José Reis de Abreu  , Mascia Márcia Aparecida Amador Mascia
Published: October 2024

Este artigo faz parte de uma tese de doutorado em Educação e tem como proposta discutir a construção subjetiva do empreendedor de si a partir da trazida do empreendedorismo para dentro da escola pública. Toma-se como objetivo rastrear nas falas dos sujeitos entrevistados como eles se subjetivam frente aos saberes do empreendedorismo. Inspirada no conceito foucaultiano de governamentalidade, a pesquisa propõe a realização de um trabalho de campo investigativo/qualitativo a partir de entrevistas semi-abertas com três sujeitos que cursaram o ensino médio técnico em escola pública e que participaram de processos de incubação de empresas desenvolvidas naquela instituição. Os resultados nos apontam como discursivamente os sujeitos vão sendo capturados e subjetivados pelo discurso do empreendedorismo mas, também, como pelas falas surgem momentos de resistência.
TEORIA CRÍTICA PARA O INCONFORMISMO
Authors: Medeiros Robles Aguiar Cintia , Muleka Mwewa Christian , Sueme Winkler Oshiro Galindo Julyana , Caldeira Ferreira Juliani Lucinda , Gabriele Apolinário Vitória
Published: October 2024

O presente texto é parte do plano de trabalho cujo título é “XXXXX”. Nesta etapa centramos as nossas reflexões para pensar a “implementação de políticas públicas para a educação: a lei 10.639/03 e o combate ao racismo” como parte dos resultados. A pesquisa é de cunho qualitativo e utiliza procedimentos de análise documental, do campo do direito e da educação. Portanto, analisa-se a implementação das leis 10.639/03 e 11.645/08 como Política Pública de combate ao racismo na educação básica. Este objetivo específico dialogo de maneira direta com o objetivo geral, qual seja, explicitar, compreender e analisar a socialização das infâncias tangenciadas por tensões étnicas e “raciais” nos contextos formativos dos centros de educação infantil na cidade de Três Lagoas-MS. Partimos da tese de pensar a eficácia das leis promulgadas com o objetivo de tornar obrigatório o ensino da cultura afro-descente e indígena nas instituições públicas e privadas de ensino básico brasileiras para afirmarmos que as leis foram criadas com o objetivo de combater a discriminação racial e promover o conhecimento e valorização da identidade da história e cultura africana e indígena. Contudo, apresentamos as limitações formativas para a aplicação das leis pelo défict em sua formação e material didático inadequado (livro didático).
CEST conversation with Prof. Marc A. Rosen: Evolving responsibilities and contributions in science and engineering for global carbon neutrality transitions
Authors: Rosen Marc A. , Zhou Yuekuan
Published: October 2024

Prof. Marc A. Rosen is a Professor of Mechanical & Manufacturing Engineering at Ontario Tech University (formally University of Ontario Institute of Technology) in Oshawa, Canada, where he served as founding Dean of the Faculty of Engineering and Applied Science. Prof. Rosen has served as President of the Engineering Institute of Canada and of the Canadian Society for Mechanical Engineering. He has received numerous awards and honors, including an Award of Excellence in Research and Technology Development from the Ontario Ministry of Environment and Energy, the Engineering Institute of Canada Smith Medal for achievement in the development of Canada, and the Canadian Society for Mechanical Engineering Angus Medal for outstanding contributions to the management and practice of mechanical engineering. Prof. Rosen received a distinguished scholar award from Toronto Metropolitan University (formerly Ryerson University) and a Mid-Career Award from University of Toronto. He is a fellow of the Royal Society of Canada, the Engineering Institute of Canada, the Canadian Academy of Engineering, the Canadian Society for Mechanical Engineering, the American Society of Mechanical Engineers and the International Energy Foundation.
Relações palimpsestuosas do amor em "Melancia e Coco Mole": um fenômeno brasileiro que ultrapassa um século
Authors: Alves Weber Firmino , Wanderley Naelza de Araújo
Published: October 2024

Este artigo tem como objetivo discutir os conceitos de intertextualidade, pelo viés da Literatura Comparada em relação a textos da literatura popular brasileira que se relacionam como hipotextos do enredo amoroso de Melancia e Coco Mole, publicado primeiramente por Sílvio Romero em 1885. O estudo conta com as contribuições teóricas de Carvalhal (2003; 2006a; 2006b), Genette (2010), Kristeva (2005), Samoyault (2008), e entre outros. A partir destes teóricos, compara-se textos populares de temática amorosa – sejam contos ou cordéis – que brotaram como um enredo palimpsestuoso da narrativa recolhida por Romero (1985), no reconto dos seguintes autores: Lopes Neto (1912); Galvão (1948); Almeida (1951); Brandão (1960; 1982); Azevedo (2002); Haurélio (2021); Resende (1977); Sobrinho (1958); e Viana (2010). A análise mostra quão produtiva é a recepção do texto literário, sobretudo quando transita nos espaços populares, demonstrando também a liberdade criadora do leitor que se assume como criador de significados, aclimatando o texto ao seu próprio espaço, sem, contudo, desconsiderar seus hipotextos.
Produção de sentidos na escrita em língua portuguesa de uma estudante surda do ensino médio
Authors: Souza Shelton Lima de , Barros Ana Carolina Ferreira de
Published: October 2024

Este artigo é uma análise da produção de sentidos, em língua portuguesa, de uma estudante surda do Ensino Médio em uma escola na modalidade Educação de Jovens e Adultos/EJA localizada na cidade de Rio Branco, capital do estado do Acre. O estudo é de natureza qualitativa do tipo estudo de caso, com desenvolvimento de investigação a partir de pesquisa bibliográfica com dados que foram gerados por meio de observações e, por conseguinte, na Sala de Recurso Multifuncional (SRM) da produção textual de uma estudante surda que aprendeu o português como segunda língua (L2). Objetivou-se, com este trabalho, refletir sobre os processos de sentidos construídos pela participante da pesquisa em seus textos escritos e discutimos a produção e a formação de traços de significação dispostos pela estudante surda nos textos produzidos. Algumas considerações finais deste artigo apontam que os traços de sentidos produzidos na escrita da participante da pesquisa apresentam características próprias que podem ser resultantes de diferentes formas de atravessamentos (sócio)linguísticos pelos quais a escrevente passou, tendo como base uma língua visuespacial.
Prehistoric Human Occupation in The Central Part of Burkina Faso
Authors: Lassané Toubga , Benjamin Sawadogo , Hervé Farma Hantissié
Published: October 2024

From the outset, prehistoric research in Burkina Faso focused on the northern, eastern and western parts of the country. The central part that interests us in the present study was considered to be exclusively dominated by material traces from the Iron Age. This central part, located around the capital Ouagadougou, is characterized geophysically by its flat relief and is drained by the Massili, the main tributary of the Nakambé. The country’s security context, marked by terrorism, has made it one of the safest areas for the practice of field archaeology. As part of our resilience-based archaeology, we have uncovered hundreds of Iron Age and prehistoric sites on granitic outcrops. All the sites identified face a variety of problems, mainly linked to the consequences of uncontrolled urbanization and land development, which have transformed prehistoric sites, particularly into quarries. The urgency of the situation led us to carry out a rescue archaeology surface collection at three of the sites. Techno-morphological analysis of the hundred or so artefacts collected indicates the characteristics of three material cultures: Acheulean, Mousterian and Laminar. In a general context where prehistoric research is in its infancy, these new data redefine our understanding of the country’s prehistory and lay the foundations for understanding human dynamics throughout the Nakambé watershed.
The Dimensions of Timeshare: Evidence from Trip Advisor
Authors: Gregory M Amy
Published: October 2024

This study examines timeshare product dimensions based on online information on TripAdvisor. Using Leximancer, 57 main concepts and 11 major textual themes were identified. Further analysis revealed seven main dimensions: points, vacation, resorts, fees, sales, company, and deal. The most relevant theme was points, referring to the recent evolution of the timeshare product to a point-based system. The findings provide unique insight into a substantial segment of the tourism industry, differing from extant survey-based research. Results indicate that timeshare companies should not overlook information shared online as it relates to their image -- 899 posts (42%) of 2089 show negative perceptions towards timeshare. As a relatively under-researched field, this may provide a starting point for future research in this area.
Lo femenino en Lacan y su relación con la teoría general de los conjuntos. Una perspectiva lógica del psicoanálisis
Authors: Balzarini Marco Máximo
Published: October 2024

El presente trabajo se propone demostrar el uso fecundo que Jacques Lacanhace de la lógica para desarrollar sus concepciones acerca de lo femenino. Para esto vamos arecorrer brevemente aportes de Gottlob Frege y Georg Cantor que le habrían sido útiles a Lacanpara llegar a sus concepciones acerca de lo femenino. La pregunta conductora es ¿de quémanera la lógica moderna demuestra las concepciones psicoanalíticas de lo femenino?, másprecisamente, ¿de qué manera ciertos aportes de la teoría general de los conjuntos permiten aLacan abordar lo femenino en la teoría y en la clínica? La hipótesis principal es que el germende las concepciones psicoanalíticas lacanianas acerca de lo femenino hunde sus fundamentosen las concepciones de la lógica de exclusión-reunión. Lacan nos enseña que, a diferencia de lascontradicciones, las paradojas sitúan dos elementos aparentemente opuestos, pero compatibles,incluso necesariamente unidos para armar conjuntos y sostener lo que ex-siste al conjunto,lo cual resulta en una lógica que Lacan denomina no todo. Esta relación entre psicoanálisis,tanto en su doctrina como en su acto, y lógica moderna permite concluir que la lógica modernaconstituye a los fundamentos del psicoanálisis de orientación lacaniana.
Evaluación de impacto de género y transversalidad. La experiencia del Gobierno Autonómico de la Comunidad Valenciana
Authors: Díaz Pagés Almudena , Gil Junquero Monica
Published: October 2024

La evaluación de impacto de género es una herramienta central para impulsar la transversalidad de género en las políticas y en los textos normativos. En este trabajo nos centramos en los informes de evaluación previa de impacto de género (IEIG) elaborados por la administración autonómica valenciana, con el fin de contrastar cual está siendo real o efectivamente su papel en la instauración de la transversalidad de género en la Generalitat Valenciana (GVA). Hemos definido dos variables para realizar la metaevaluación de dichos IEIG: la institucionalización y la calidad. La primera de ella consta de tres dimensiones que son el marcolegal, los recursos y la cobertura. La segunda, la calidad de los IEIG, la valoramos a través de las dimensiones de estructura, contenido y tratamiento de los aspectos transversales.El análisis documental es la técnica de investigación principal, habiéndose analizado exhaustivamente una muestra de 268 informes de evaluación de impacto de género elaborados por la GVA en el periodo comprendido entre 2015 y 2022. La selección de los informes se basó en su disponibilidad en las páginas web institucionales de las diferentes consellerias. De manera subsidiaria, también se han tenido en cuenta para la investigación, los datos extraídos de una entrevista en profundidad.Entre los resultados obtenidos observamos que los informes de evaluación de impacto de género de la GVA presentan una extendida pero débil institucionalización, al tiempo que muestran una baja calidad. De esta realidad se desprenden una serie de propuestas de mejora. Entre ellas, el establecimiento de mecanismos de seguimiento y evaluación de los informes de evaluación de impacto de género que permitan mejorar su calidad y con ella, avanzar en materia de institucionalización de la transversalidad de género.
Governança de festas populares
Authors: Almeida Filho Aétio , Davel Eduardo
Published: October 2024

Festas populares são manifestações que expressam identidade, envolvendo diversos atores sociais em uma estrutura complexa de governança. Apesar de recentes e pouco consolidadas, as pesquisas sobre gestão de festas populares indicam a necessidade de um sistema de governança adaptado a esse contexto. O objetivo deste artigo é desenvolver um sistema de gestão para festas populares baseado na governança colaborativa e na identidade cultural. A metodologia de pesquisa é de natureza indutiva e exploratória, fundamentada em documentos e entrevistas. Os resultados configuram a TGPop (Tecnologia de Governança de Festas Populares), constituída de fases (preparação, estratégia, execução e avaliação) e dimensões (colaboração, identidade cultural e conflito). Os resultados contribuem para repensar a teorização e a prática de gestão de festas populares.
APLIKASI MODEL TREND UNTUK MEMPREDIKSI PRODUKSI KELAPA SAWIT PROVINSI KALIMANTAN SELATAN
Authors: Salam Nur , Lestia Aprida Siska , Jannah Noor , Firdaus Muhammad
Published: October 2024

The plantation sector has a large and extensive reach, one type of plantation crop that is widely cultivated in Indonesia is oil palm. Business in the oil palm plantation sector is also one of the leading potential areas in South Kalimantan Province. One of the provinces producing the most palm oil in Indonesia is South Kalimantan Province. This research is a literature study regarding predictions of palm oil production. The aim of this research is to determine the appropriate prediction model for data on the amount of palm oil (CPO) production in the South Kalimantan Province Region and to explain the results of palm oil predictions in the South Kalimantan Province Region using a trend model. The application of the trend model used in this research takes into account the error value obtained with the smallest MAPE (Mean Absolute Percentage Error). The nature of the data regarding the amount of palm oil production in the South Kalimantan Province Region from 2001 to 2021 tends to continue to increase so that the data can be predicted using trend methods, namely linear, quadratic and exponential. For the prediction results of palm oil production using the best trend model with the smallest MAPE value, namely 16% with the linear trend model: ... The predicted amounts of palm oil production from 2022 to 2027 which tend to continue to increase are: 1.336.359, 1.397.196, 1.458.032, 1.518.869, 1.579.705 and 1.640.542 tons.
ANALISIS SENSITIVITAS MODEL EPIDEMI SIR DAN SVIR PADA PENYAKIT MENULAR
Authors: Munaira Hanna , Yulida Yuni , Karim Muhammad Ahsar
Published: October 2024

Penyakit menular merupakan penyakit yang disebabkan oleh mikroorganisme patogen seperti bakteri, virus, parasit, atau jamur. Penyakit ini dapat menyebar, baik secara langsung maupun tidak, dari satu individu ke individu lainnya. Penyebaran penyakit menular dapat dimodelkan dengan pemodelan matematika epidemi Kermack-McKendrick. Penelitian ini bertujuan untuk menjelaskan pembentukan model matematika, menentukan titik ekuilibrium serta bilangan reproduksi dasar, dan menganalisis kestabilan lokal pada model matematika. Selain itu, dilakukan analisis sensitivitas terhadap bilangan reproduksi dasar dan simulasi numerik dengan metode Runge-Kutta orde 4. Dari penelitian ini, diperoleh bentuk model epidemi SIR (Susceptible, Infected, Recovered) dan modifikasi model tersebut menjadi model SVIR (Susceptible, Vaccinated, Infected, Recovered). Berdasarkan model yang terbentuk, diperoleh titik ekuilibrium bebas penyakit dan titik ekuilibrium endemik pada masing-masing model. Bilangan reproduksi dasar masing-masing model ditentukan dengan menggunakan metode Next Generation Matrix. Kemudian, dengan menggunakan nilai eigen dari matriks Jacobian, diketahui jenis kestabilan kedua model pada masing-masing titik ekuilibrium adalah stabil asimtotik lokal dengan syarat tertentu. Analisis sensitivitas menunjukkan parameter yang paling sensitif terhadap perubahan bilangan reproduksi dasar jika diurutkan dari yang terbesar untuk model SIR adalah laju penularan, laju kelahiran/kematian, dan laju kesembuhan. Sedangkan, untuk model SVIR adalah laju penularan, laju kelahiran/kematian, laju kesembuhan, dan proporsi populasi yang telah divaksinasi. Analisis-analisis ini juga diperkuat oleh hasil simulasi numerik.
Adherence to The Mediterranean Dietary Pattern and Associated Factors Among Adolescents: a Cross-sectional Study from Portugal
Authors:   Faculdade de Ciências  da Nutrição e Alimentação  da Universidade do Porto,  Rua do Campo Alegre,  n.º 823,  4150-180 Porto, Portugal, Jorge Inês , Poínhos Rui ,   Faculdade de Ciências  da Nutrição e Alimentação  da Universidade do Porto,  Rua do Campo Alegre,  n.º 823,  4150-180 Porto, Portugal, Rei Mariana ,   Faculdade de Ciências  da Nutrição e Alimentação  da Universidade do Porto,  Rua do Campo Alegre,  n.º 823,  4150-180 Porto, Portugal,   EPIUnit – Instituto  de Saúde Pública da  Universidade do Porto,  Rua das Taipas, n.º 135,  4050-600 Porto, Portugal,   Laboratório para a  Investigação Integrativa e  Translacional em Saúde  Populacional (ITR) da  Universidade do Porto,  Rua das Taipas, n.º 135,  4050-600 Porto, Portugal, Rodrigues Sara ,   Faculdade de Ciências  da Nutrição e Alimentação  da Universidade do Porto,  Rua do Campo Alegre,  n.º 823,  4150-180 Porto, Portugal,   EPIUnit – Instituto  de Saúde Pública da  Universidade do Porto,  Rua das Taipas, n.º 135,  4050-600 Porto, Portugal,   Laboratório para a  Investigação Integrativa e  Translacional em Saúde  Populacional (ITR) da  Universidade do Porto,  Rua das Taipas, n.º 135,  4050-600 Porto, Portugal
Published: October 2024

INTRODUCTION: The Mediterranean Dietary Pattern is one of the healthiest dietary models, being associated with several health benefits. However, in recent years, this pattern has been abandoned by adolescents in Mediterranean countries. OBJECTIVES: To determine and analyze the adherence to the Mediterranean Dietary Pattern and its associated factors in a sample of adolescents from a city in the north of Portugal. METHODOLOGY: Cross-sectional study. The data was collected via a stratified one-stage cluster sampling of adolescents (10 to 19 years old) from a city in the north of Portugal. The Mediterranean Diet Quality Index (KIDMED Index) was self-administered to evaluate the adherence to the Mediterranean Dietary Pattern among adolescents. Participants self-reported information about sociodemographic, anthropometric and lifestyle characteristics. Logistic regression was performed to identify the predictors of high adherence to the Mediterranean Dietary Pattern. RESULTS: Most adolescents had a low/moderate adherence to the Mediterranean Dietary Pattern (63.2%). Logistic regression modelling indicated that age and parents’ educational level were the utmost factors positively related to the possibility of high Mediterranean Dietary Pattern adherence. Sex, school location, body mass index and number of household members did not significantly predict high Mediterranean Dietary Pattern adherence. CONCLUSIONS: These results highlight the importance of the parents’ education level in adolescents’ Mediterranean Dietary Pattern adherence, allowing the identification of the priority groups for a possible intervention, namely, younger adolescents and those whose parents have lower educational level.
Impacto na Saúde da Carboximetilcelulose
Authors:   Escola Superior de  Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  3046-854 Coimbra,  Portugal, Gameiro Joana , Soares Inês ,   Escola Superior de  Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  3046-854 Coimbra,  Portugal, Santos Mariana ,   Escola Superior de  Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  3046-854 Coimbra,  Portugal, Cabral Matilde ,   Escola Superior de  Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  3046-854 Coimbra,  Portugal, Matias Sofia ,   Escola Superior de  Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  3046-854 Coimbra,  Portugal, Baltazar Ana Lúcia ,   Escola Superior de  Tecnologia da Saúde  de Coimbra do Instituto  Politécnico de Coimbra,  Rua 5 de Outubro,  3046-854 Coimbra,  Portugal
Published: October 2024

INTRODUÇÃO: A carboximetilcelulose de sódio é um polissacárido hidrossolúvel derivado da celulose, adicionado aos alimentos como estabilizador, emulsionante, espessante, humectante, ligante, gelificante e revestimento. É um aditivo alimentar, classificado como E466 na Europa, cuja dose diária aceitável não é especificada. A carboximetilcelulose de sódio possui uma elevada disponibilidade e um baixo custo associado, tendo uma vasta gama de aplicações, tais como na indústria alimentar, por preservar a qualidade e melhorar as características dos produtos. OBJETIVOS: Estudar a carboximetilcelulose de sódio, as suas aplicações e toxicidade, bem como a extensão do seu impacto na saúde humana. METODOLOGIA: Foi realizada uma revisão bibliográfica nas bases de dados Pubmed e Sciencedirect, utilizando as palavras-chave "Carboxymethylcellulose AND Nutrition AND Toxicology AND Cellulose gum AND Emulsifier". Foram analisados 52 artigos pelo título, 39 após análise do resumo e 30 para leitura do texto na íntegra, obtendo 25 artigos, publicados nos últimos dez anos, para elaboração do presente artigo. RESULTADOS: Em três estudos realizados em ratos, verificou-se que a carboximetilcelulose de sódio poderia alterar a microbiota intestinal, promover a inflamação da gota e a obesidade, prejudicar o controlo glicémico, não sendo hematotóxica nem hepatotóxica. Apesar da falta de testes de segurança extensivos, a carboximetilcelulose de sódio foi aprovada para utilização em alimentos em concentrações até 2% pelas agências reguladoras. Presume-se que a carboximetilcelulose de sódio é segura, uma vez que não é bem absorvida e é na sua maioria eliminada nas fezes. Contudo, tal passagem através do intestino permite-lhe interagir diretamente com a microbiota intestinal, o que pode contribuir para o aumento da incidência de doenças inflamatórias crónicas. CONCLUSÕES: Apesar da maioria dos estudos relatarem que a carboximetilcelulose de sódio não é tóxica, para a sua utilização mais segura, é necessário analisar os seus efeitos toxicológicos mais minuciosamente e avaliar com precisão os seus riscos para a saúde humana.
Language Features Found in Essays About Madurese Art
Authors: PUTRI SHEILA AYU RIRIS ANDIKA , Al Rosyiidah Afiifah
Published: October 2024

This study aims to examine and explain language features in essays about Madurese arts. The writers uses qualitative descriptive methods to elaborate data. The source of the data in this study is essays by second semester students of English Department at Universitas Trunojoyo Madura which discuss about Madurese art. Meanwhile, the data  of this study are characters, sentences, and paragraphs in essays that contain various language features. This study uses Gerot and Wignell (1995) theory of language features in descriptive essays. The result of this study shows that there are five language features that students use in their essays: the use of certain objects, the use of simple present tense, the use of noun and adjective phrases, the use of  auxiliary, and the use of linking verb.
Speech Act Analysis of Harry and Meghan’s Interview with Oprah Winfrey on CBS Morning News Show
Authors: Rifai Irfan
Published: October 2024

This article is aimed at finding out types of illocutionary acts found in one of the most shocking viral interviews in the world, that is the interview with the royal family of former member, Harry and Meghan Markle interviewed by Oprah Winfrey, with amount of viewership of 4.79 million viewers when it first shows on air. This research is framed within mixed-method approach where the results of the study are in the form of an overview of what is said (illocutionary acts) by the three main subjects, namely Harry, Meghan, and Oprah and the percentage of each type of illocutionary acts. Data analysis was conducted through the analysis of interview videos along with the transcripts, simple statistical analysis and is supported by literature study. The results of the current study show that from 319 data of 644 sentences indicated as illocutionary acts. From those findings, it can be categorized that there are five types of illocutionary acts were found in an interview, they are 63% assertive, 27% directives, 0,6% commissive, 7,3% expressive, and 0,3% declarative. In other words, assertive is found to be the dominant type of illocutionary acts. In addition, of the 319 data, 295 data are categorized as direct speech act and 24 data are indicated as indirect speech act. In short, illocutionary acts of assertive type and direct speech acts are found to be more dominant in Harry and Meghan interview with Oprah Winfrey.
An Approximate Solution of Fredhom Integral Equation Using Bernstein Polynomials
Authors: Ali Haleema S. , Ali Waleeda S.
Published: October 2024

في هذا البحث استخدمت طريقة متعددة حدود برنشتن التقريبية  لإيجاد  الحل التقريبي لمعادلة فريدهولم التكاملية من النوع الثاني. كما أن متعددة الحدود تستعمل بشكل كبير في الطرق الرياضية وذلك لبساطة تعريفها ولسهولة وسرعة الحسابات فيها. وتنوع دوالها.
Reflection on the Concept of Conscience: a Comparative Analysis of Approaches in Arab-Turkic Islamic Philosophy
Authors:   Azerbaijan Institute of Theology, Gafarov Anar ,   Azerbaijan National Academy of Sciences
Published: October 2024

The concept of conscience is one of the main unsolved problems of moral philosophy. It is of great importance to reveal the discussions about this con­cept until today collectively on the philosophical level, in terms of clarifica­tion the questions related to the source of morality and moral propositions and the subjectivity or objectivity of ethical values. We can evaluate the ex­planations related to the concept of conscience in two categories as etymolo­gical and terminological. While explanations on the etymology of the con­cept are naturally based on classical dictionaries, conceptual explanations are based on classical, medieval and modern Western and Islamic moral philo­sophy texts. The main purpose of the study is to discuss the moral content of the concept of conscience in the light of Islamic philosophies compara­tively, based on the basic works related to the concept in Islamic thought. The main thesis of the study is that conscience is a deeply appealing power that has metaphysical, psychological and epistemological aspects. Conse­quently, we can define conscience as a spiritual force with cognitive, emo­tional, and voluntary aspects
Modernity Named after Immanuel Kant. On the Question of Theoretical and Practical Origins of the Project of Modernity
Authors:   Institute of Philosophy, Russian Academy of Sciences, Afanasov Nikolai
Published: October 2024

The article discusses the question of the theoretical and practical origins of the project of Modernity in the philosophy of Immanuel Kant. The theory of reflexive modernity was emerging in the second half of the 20th century. Ac­cording to its positions, historical development and social transformations derive their energy from resolving emerging contradictions through an appeal to the pub­lic reason. Modernity turns out to be a fundamentally mobile and dialogical process, the maintenance of which requires a complex culture of thought and ac­tion. The author offers a critical view at the optimistic sentiments of the theorists of the end of the last century, who considered the emerging contradictions to be fundamentally solvable. The ambiguous consequences of the end of globaliza­tion, the environmental crisis and the digitalization of everyday life turned out to be among the main reasons for rethinking the general framework of theorizing about modernity as a project that must be consistently implemented. The claim to build a general theory of modernity has given way to alarmist and situational discourses, although the influence of the Western rationalist attitude remains. The article hypothesizes that one of the reasons for the crisis of the philosophical narrative about modernity was the ideologization of Enlightenment thought. Thus, the ideas of I. Kant turned into ideologemes justifying the existing world order, the beneficiaries of which are a minority. The author shows that de­spite the existing grounds for this, we are talking about a private interpretation of the principles of practical philosophy of the German philosopher. Actual modernity can rightfully bear the name of Immanuel Kant, but it is the critical analysis of its most widespread interpretation that can be productive for solving the key problems of the modern world
A Qualitative Meta-analysis of Elementary School Teachers’ Experience in Creative-Experiential Activities
Authors: Choi Ryumi , Lee Doyeong
Published: October 2024

Objective: Using a qualitative meta-analysis, this study examines whether elementary school teachers' experiences in organizing and operating creative experiential activities are being implemented in actual school sites as intended and proposes ways to internalize the quality of these activities.
Methods: Eight domestic qualitative studies on the said experience were analyzed in a larger framework of curriculum organization, implementation, and evaluation according to Novlit and Hare’s (1998) seven-step qualitative meta-analysis approach.
Results: Elementary school teachers had conflicting views on teacher autonomy in organizing, managing, and evaluating creative experiential activities. Further, they differed in their experiences in different areas of creative experiential and out-of-school activities. The study also elicited opinions on how to evaluate creative experiential activities and improve professional development related activities.
Conclusions: Suggestions were made for improving the creative experiential activity curriculum and follow-up research, such as providing opportunities to cultivate teacher expertise related to creative experiential activities, exploring teacher and student experiences by activity area and alternative creative experience evaluation measures.
Characterizing the photoluminescence of fluorescein-labeled cellulose in aqueous and alcohol solutions: influence of the cellulose backbone
Authors: Yen Chi-Yang , Rana Shailesh , Awasthi Kamlesh , Ohta Nobuhiro , Oh-e Masahito
Published: October 2024

Although many dyes have been introduced into cellulose, whether bound to its backbone or within a cellulose matrix, few studies have determined whether the backbone statically or dynamically quenches the dye’s photoluminescence. To advance cellulosic fluorescent films, the cellulose backbone’s influence on photoluminescence must be understood. We determined the fluorescence properties of fluorescein isothiocyanate (FITC) and fluorescein-labeled cellulose (FLC) in water and alcohol, including their quantum yields ϕPL, lifetimes τ, and rates of radiative k_r and nonradiative knr decay. Dissolved FLC had a ~30× lower ϕPL than FITC, suggesting that incorporating FITC into the cellulose backbone remarkably reduces the fluorescence efficiency. The FLC solutions had a 6-fold lower kr than their FITC counterparts but a 10–20 times higher knr. Presumably, this was because the cellulose backbone interacted weakly with the fluorescein moieties, suggesting a quenching mechanism that can be termed quasi-static, corresponding to static quenching between the fluorescein moieties and cellulose backbone, in addition to the fluorescence quenching caused by the intramolecular nonradiative processes of fluorescein, as observed in conventional molecules. Using the Strickler‒Berg formula, we deduced the analytical radiative decay rate constants krS.B. and eventually estimated the number of very short-lived fluorescein moieties per single fluorescent fluorescein moiety, corresponding well with static quenching.
Sequential DC-intrinsic Lymphotoxin Beta Receptor and Retinoic Acid Receptor signals regulate cDC2 fates
Authors: Gommerman Jennifer , Nguyen Albert , Fisher Logan , Maitre Blandine , Ahn Jennifer , Dasoveanu Dragos , Li Conglei , Ward Lesley , Tayyebi Zakieh , Wang Angela , Yadav Anushka , Park Tyler , Rudensky Alexander , Mendelsohn Cathy , Brown Chrysothemis
Published: October 2024

Type II conventional dendritic cells (cDC2) are functionally and phenotypically heterogenous. Previous work identified two major cDC2 subsets (cDC2A and cDC2B); however, the underlying microenvironmental cues governing their distinct differentiation pathways remain unclear. Here we delineate the sequential signals required for cDC2A specification and maintenance. We show that T-bet+ cDC2A, arising from the Clec9a+ DC progenitor, express the retinol receptor RBPR2, require cell-intrinsic retinoic acid (RA) signaling for their maintenance in the spleen and gut-associated lymphoid tissues, and depend on intrinsic RA receptor signaling to sustain downstream Notch signals. Prior to their expression of T-bet, splenic cDC require cell-intrinsic Lymphotoxin beta receptor (LTβR) expression for RA-dependent cDC2A accumulation and LTβR-deficient splenic cDC2A have compromised preferential access to blood with increased F-actin content. We propose a novel mechanism whereby splenic cDC2-intrinsic LTβR signaling promotes access to blood-borne macromolecules such as retinol to promote cDC2A development.
Relationships between students' stress, anxiety and depression and; parents' obsessive‒compulsive disorder
Authors: Rezvanpour Mohammad , Ganjeh Fatemeh , Rafiei Fatemeh , Khosravi Sharareh
Published: October 2024

Background
According to the World Health Organization, stress disorders, anxiety and depression are among the most common mental disorders in the adolescent age group. These disorders have a lot of negative effects on the educational process, social relations and mental and physical health of teenagers. Currently, among mental disorders, the impact of parental depression and anxiety on children's depression and anxiety is known and accepted, but studies conducted on the impact of other parental mental disorders on children's health are limited. Obsessive compulsive disorder is an important mental disorder due to its prevalence and associated disabilities, and patients with obsessive compulsive disorder have an adverse effect on the quality of life of their relatives. Therefore, this study was conducted with the aim of investigating the relationships between parents' obsessive‒compulsive disorder and students' stress, anxiety, and depression.
Methods
In this descriptive-analytical and cross-sectional study, 378 students aged 12 to 15 years from Arak city and their parents were selected by simple random cluster sampling. The data were collected via two standard questionnaires, the Maudsley Obsession Scale and the Stress, Anxiety and Depression Questionnaire (DASS-21), and were analyzed via SPSS 26 software.
Results
According to the findings of this research, the prevalence rates of stress, anxiety and depression at mild to very severe levels among the students were 32%, 40.7% and 36.3%, respectively. The percentage of obsessive-compulsive disorder in the parents of the study was 14.5%. There was a positive and significant relationship between students' stress and anxiety and parents' obsessive‒compulsive disorder (p = 0.0001), but no significant relationship was observed between depression and parents' obsessive‒compulsive disorder (p = 0.181).
Conclusions
The presence of obsessive‒compulsive disorder in parents was associated with greater stress and anxiety in students, and the presence of obsessive‒compulsive disorder in parents increased the severity of these disorders; however, the presence of obsessive‒compulsive disorder in parents was not related to students' depression.
Trial registration:
Arak University of Medical Sciences. ID: IR.ARAKMU.REC.1402.207
Mevalonate kinase inhibits anti-tumor immunity by impairing the tumor cell-intrinsic interferon response in microsatellite instability colorectal cancer
Authors: Zhang Yanqiao , Liao Yuanyu , Yang Rui , Wang Bojun , Ruan Yuli , Cui Luying , Yang Jiani , Yu Xuefan , Han Shuling , Yao Yuanfei , Luan Xindi , Li Yingjue , Shi Mengde , Li Shuijie , Liu Chao
Published: October 2024

Background
Inadequate tumor cell-intrinsic interferon response leads to limited efficacy of immune checkpoint blockade (ICB) therapy, such as anti-PD-1. Cholesterol metabolism can sharply regulate anti-tumor immune response. However, the mechanism of cholesterol synthesis affects the tumor cell-intrinsic interferon response in microsatellite instability (MSI) colorectal cancer (CRC) remains unclear.
Method
Small interfering RNA(siRNA) libraries and GSEA enrichment analysis are employed to screen out the key molecular which affects the tumor cell-intrinsic interferon response in MSI CRC. Mass cytometry and multiple immunofluorescence (mIF) for detecting changes in tumor micro-environment. The confocal immunofluorescence (IF), truncated protein construction, and co-immunoprecipitation (co-IP) were utilized to investigate the mechanism. The efficacy of immunotherapy were assessed in subcutaneous transplantation tumor models and human peripheral blood mononuclear cells-patient derived xenografts(hPBMC-PDX) models.
Results
Using the siRNA library and GSEA analysis, we revealed that mevalonate kinase (MVK) notably impairs the tumor cell-intrinsic interferon response in MSI CRC cells. After MVK gene knockout, the levels of Th1 type chemokines (CXCL9 and CXCL10) and the abundance of CD8+T cells were increased in tumor, and tumor growth was significantly slowed in mice with intact immune systems. Mechanistically, MVK interacts with the transcriptional activation domain (TAD) of signal transducer and activator of transcription 1 (STAT1), a key transcription factor in the interferon response. This interaction leads to reduced nuclear translocation of STAT1, ultimately impacting interferon reactivity. In the analysis of the hPBMC-PDX model and the MSI CRC clinical cohort, we observed that a low level of MVK in tumors is associated with a significant efficacy of anti-PD-1 therapy.
Conclusion
MVK is the crucial medium in the cholesterol metabolism to inhibit the tumor cell-intrinsic interferon response of tumor cells. Moreover, targeting MVK is promising to increase the efficacy of ICB therapy by increasing the interferon response in MSI CRC.
Design and Predict Tetragonal van der Waals Layered Quantum Materials of MPd5I2 (M=Ga, In and 3d Transition Metals)
Authors: Nepal Niraj , Slade Tyler , Blawat Joanna , Eaton Andrew , Palmstrom Johanna , Ueland B. , Kaminski Adam , McQueeney Robert , McDonald Ross , Canfield Paul , Wang Lin-Lin
Published: October 2024

Quantum materials with stacking van der Waals (vdW) layers that can host non-trivial band structure topology and magnetism have shown many interesting properties. Here using high-throughput density functional theory calculations, we design and predict tetragonal vdW-layered quantum materials in the MPd5I2 structure (M = Ga, In and 3d transition metals). Our study shows that besides the known AlPd5I2, the -MPd5- structural motif of three-layer slabs separated by two I layers can host a variety of metal elements giving arise to topological interesting features and highly tunable magnetic properties in both bulk and single layer 2D structures. Among them, TiPd5I2 and InPd5I2 host a pair of Dirac points and a likely strong topological insulator state for the band manifolds just above and below the top valence band, respectively, with their single layers possibly hosting quantum spin Hall states. CrPd5I2 is a ferromagnet with a large out-of-plane magneto-anisotropy energy, desirable for rare-earth-free permanent magnets.
Popliteal plexus block compared with tibial nerve block on rehabilitation goals following total knee arthroplasty: a randomized non-inferiority trial
Authors: Sakai Norihiro , Adachi Takamasa , Sudani Tomoko , Taruishi Chieko , Uematsu Yuki , Takada Motoshi
Published: October 2024

This trial examined the effectiveness of the popliteal plexus block (PPB) and tibial nerve block (TNB) for early rehabilitation after total knee arthroplasty (TKA). We allocated 136 participants to receive PPB or TNB with 0.25% levobupivacaine 10 mL in a randomized, double-masked manner. The primary outcome was achieving rehabilitation goals with a non-inferiority 9-hour margin, including adequate pain relief, knee flexion angles over 90 degrees, and enabling ambulatory rehabilitation. The time to reach rehabilitation goals showed non-inferiority with 49.7 ± 10.5 hours for TNB and 47.4 ± 9.7 hours for PPB, whose mean difference (PPB - TNB) was − 2.3 hours (95% CI -5.8 to 1.2 hours; P < 0.001). PPB showed higher dorsal and plantar percentage of maximum voluntary isometric contraction (dorsal, PPB 87.7% ± 11.4% vs. TNB 74.0% ± 16.5%: P < 0.001; plantar, PPB 90.9% ± 10.3% vs. TNB 72.1% ± 16.0%; P < 0.001) at six hours after nerve block. No significant differences between the two groups emerged in pain scores, knee range of motion, additional analgesic requirements, success in the straight leg raise, and adverse events. PPB exhibited non-inferiority to TNB in achieving postoperative rehabilitation goals and had superiority in preserving foot motor strength after TKA. (200)
Force Adaptation across Ages: Investigation of Internal Models in Early Childhood and Adulthood
Authors: Faßbender Laura , Falck Johannes , López Francisco M. , Shing Yee Lee , Triesch Jochen , Schwarzer Gudrun
Published: October 2024

Adapting movements to rapidly changing conditions is fundamental for interacting with our dynamic environment. This adaptability relies on internal models that predict and evaluate sensory outcomes to adjust motor commands. Even infants anticipate object properties for efficient grasping, suggesting the use of internal models. However, how internal models are adapted in early childhood remains largely unexplored. This study investigated a naturalistic force adaptation task in 1.5-, 3-year-olds, and young adults. Participants opened a drawer with temporarily increased resistance, creating sensory prediction errors between predicted and actual drawer dynamics. After perturbation, all age groups showed lower peak speed, longer movement time, and more movement units with trial-wise changes analyzed as adaptation process. Results revealed no age differences in adapting peak speed and movement units, but 1.5- and 3-year-olds exhibited higher trial-to-trial variability and were slower in adapting their movement time, although they also adapted their movement time more strongly. Upon removal of perturbation, we found significant aftereffects across all age groups, indicating effective internal model adaptation. These results suggest that even 1.5-year-olds form internal models of force parameters and adapt them to reduce sensory prediction errors, possibly through more exploration and with more variable movement dynamics compared to adults.
Neoadjuvant immunochemotherapy—a promising strategy for primary pulmonary lymphoepithelioma-like carcinoma
Authors: Chen Jiawei , Fan Lei , Deng Hongsheng , Li Liang , Li Shuben
Published: October 2024

Objective:
Neoadjuvant immunochemotherapy becomes a promising choice for patients with locally advanced non-small cell cancer (NSCLC). However, whether neoadjuvant immunochemotherapy impacted the subsequent surgical or pathological outcomes of patients with pulmonary lymphoepithelioma-like carcinoma (PLELC) remains relatively unknown. This study aimed to evaluate the safety and efficacy of neoadjuvant immunochemotherapy in PLELC patients.
Methods:
A retrospective study was conducted on patients who received neoadjuvant immunochemotherapy in combination with chemotherapy followed by surgery between 2019 and 2022. The clinical records of the patients were analyzed.
Results:
Out of the 31 patients with PLELC who underwent neoadjuvant therapy followed by surgery, 18 patients (58.0%) experienced downstaging of the tumor. Nineteen patients (61.5%) achieved a partial response, 2 patients (6.4%) achieved a complete response, and 2 (6.4%) had progressive disease. Pathological evaluation of resected specimens revealed that 10 (32.3%) patients achieved major pathological response (MPR), including 2 (6.4%) who achieved complete response (CR). The mean disease-free survival (DFS) was 17.4 months, which was not significantly different from the value in LUSQ patients (15.1 months).
Conclusion:
Neoadjuvant immunochemotherapy is a safe and effective approach to reduce the extent of tumor, render unresectable to resectable, and offer an opportunity to receive modified surgery, which may be a promising strategy for patients with PLELC.
Identifying populations at high risk of malaria: a mixed-methods case control study to inform targeted interventions in Senegal
Authors: Thiam Tidiane , Kande Demba , Ntuku Henry , Guinovart Caterina , Galles Natalie , Merriman Laura , Cissé Moustapha , Sall Abiboulaye , Diop Ndack , Diouf Aichatou Barry , Diaw Mama Moussa , Diop Mamadou , Camara Baba , Seck Niene , Ndour Aliou , Dieye Yakou , Smith Jennifer , Bennett Adam
Published: October 2024

Background
Senegal has made significant progress in reducing the burden of malaria, but transmission remains highly heterogeneous, with specific population subgroups likely at higher risk. Consultations with the national malaria control program (NMCP) and a review of available data identified nomadic pastoralists, gold miners, and Koranic school students as potential high-risk populations (HRPs). We evaluated whether these populations are at higher risk of malaria and better characterized their exposure patterns to inform the design of targeted intervention strategies.
Methods
A mixed-methods study was conducted in the districts of Ranérou, Kaolack, and Saraya between November 2020 and December 2021. A formative assessment including key informant interviews (KII) and focus group discussions (FGD) was conducted with non-HRP and HRP members (nomadic pastoralists, gold miners, Koranic school students). A health facility-based case-control study was then conducted in nine health facilities across the three districts. 501 confirmed malaria cases and 1002 non-malaria controls were frequency matched by age and sex with a ratio of 1:2. A standardized questionnaire was administered to collect sociodemographic information, including occupation, use of malaria prevention measures, mosquito exposure, and travel history. Multivariable logistic regression was used to identify malaria risk factors.
Results
KIIs and FGDs indicated that nomadic pastoralists, gold miners and Koranic school students have high exposure to mosquito bites through outdoor sleeping, spending time outside at night and sleeping in informal structures, with important gaps in the coverage of indoor residual spraying (IRS) and long-lasting insecticidal nets (LLINs) and limited access to health services. Compared to controls, cases had higher odds of being a nomadic pastoralist (odds ratio (OR) 4.67 95% CI 1.96–11.11) or gold miner (OR 1.92 95% CI 1.20–3.07). No evidence was found of an association with being a Koranic school student (OR 1.39 95% CI 0.80–2.39).
Conclusions
Nomadic pastoralists and gold miners in the study areas are at higher risk of malaria. Targeted interventions are needed to cover gaps in malaria prevention coverage and access to health services.