bluuebunny/crossref_metadata_2025 huggingface dataset:
The Fst/Ldr Family of Type I TA System Toxins: Potential Roles in Stress Response, Metabolism and Pathogenesis
Authors: Weaver Keith
Published: July 2020

The parpAD1 locus was the first type I toxin–antitoxin (TA) system described in Gram-positive bacteria and was later determined to be the founding member of a widely distributed family of plasmid- and chromosomally encoded TA systems. Indeed, homology searches revealed that the toxin component, FstpAD1, is a member of the Fst/Ldr superfamily of peptide toxins found in both Gram-positive and Gram-negative bacteria. Regulation of the Fst and Ldr toxins is distinct in their respective Gram-positive and Gram-negative hosts, but the effects of ectopic over-expression are similar. While, the plasmid versions of these systems appear to play the canonical role of post-segregational killing stability mechanisms, the function of the chromosomal systems remains largely obscure. At least one member of the family has been suggested to play a role in pathogenesis in Staphylococcus aureus, while the regulation of several others appear to be tightly integrated with genes involved in sugar metabolism. After a brief discussion of the regulation and function of the foundational parpAD1 locus, this review will focus on the current information available on potential roles of the chromosomal homologs.
Reversal of T Cell Exhaustion in Chronic HCV Infection
Authors: Osuch Sylwia , Metzner Karin J. , Caraballo Cortés Kamila
Published: July 2020

The long-term consequences of T cell responses’ impairment in chronic HCV infection are not entirely characterized, although they may be essential in the context of the clinical course of infection, re-infection, treatment-mediated viral clearance and vaccine design. Furthermore, it is unclear whether a complete reinvigoration of HCV-specific T cell response may be feasible. In most studies, attempting to reverse the effects of compromised immune response quality by specific blockades of negative immune regulators, a restoration of functional competence of HCV-specific T cells was shown. This implies that HCV-induced immune dysfunction may be reversible. The advent of highly successful, direct-acting antiviral treatment (DAA) for chronic HCV infection instigated investigation whether the treatment-driven elimination of viral antigens restores T cell function. Most of studies demonstrated that DAA treatment may result in at least partial restoration of T cell immune function. They also suggest that a complete restoration comparable to that seen after spontaneous viral clearance may not be attained, pointing out that long-term antigenic stimulation imprints an irreversible change on the T cell compartment. Understanding the mechanisms of HCV-induced immune dysfunction and barriers to immune restoration following viral clearance is of utmost importance to diminish the possible long-term consequences of chronic HCV infection.
Yellow Fever Virus Down-Regulates mRNA Expression of SOCS1 in the Initial Phase of Infection in Human Cell Lines
Authors: Yakass Michael B. , Franco David , Quaye Osbourne
Published: July 2020

Flaviviruses are constantly evolving diverse immune evasion strategies, and the exploitation of the functions of suppressors of cytokine signalling (SOCS) and protein inhibitors of activated STATs (PIAS) to favour virus replication has been described for Dengue and Japanese encephalitis viruses but not for yellow fever virus (YFV), which is still of global importance despite the existence of an effective vaccine. Some mechanisms that YFV employs to evade host immune defence has been reported, but the expression patterns of SOCS and PIAS in infected cells is yet to be determined. Here, we show that SOCS1 is down-regulated early in YFV-infected HeLa and HEK 293T cells, while SOCS3 and SOCS5 are not significantly altered, and PIAS mRNA expression appears to follow a rise-dip pattern akin to circadian-controlled genes. We also demonstrate that YFV evades interferon-β application to produce comparable viral titres. This report provides initial insight into the in vitro expression dynamics of SOCS and PIAS upon YFV infection and a basis for further investigation into SOCS/PIAS expression and how these modulate the immune response in animal models.
Application of Reverse Genetics in Functional Genomics of Potyvirus
Authors: Kannan Maathavi , Zainal Zamri , Ismail Ismanizan , Baharum Syarul Nataqain , Bunawan Hamidun
Published: July 2020

Numerous potyvirus studies, including virus biology, transmission, viral protein function, as well as virus–host interaction, have greatly benefited from the utilization of reverse genetic techniques. Reverse genetics of RNA viruses refers to the manipulation of viral genomes, transfection of the modified cDNAs into cells, and the production of live infectious progenies, either wild-type or mutated. Reverse genetic technology provides an opportunity of developing potyviruses into vectors for improving agronomic traits in plants, as a reporter system for tracking virus infection in hosts or a production system for target proteins. Therefore, this review provides an overview on the breakthroughs achieved in potyvirus research through the implementation of reverse genetic systems.
Respiratory Syncytial Virus Infection Induces Chromatin Remodeling to Activate Growth Factor and Extracellular Matrix Secretion Pathways
Authors: Xu Xiaofang , Qiao Dianhua , Mann Morgan , Garofalo Roberto P. , Brasier Allan R.
Published: July 2020

Lower respiratory tract infection (LRTI) with respiratory syncytial virus (RSV) is associated with reduced lung function through unclear mechanisms. In this study, we test the hypothesis that RSV infection induces genomic reprogramming of extracellular matrix remodeling pathways. For this purpose, we sought to identify transcriptionally active open chromatin domains using assay for transposase-accessible-next generation sequencing (ATAC-Seq) in highly differentiated lower airway epithelial cells. High confidence nucleosome-free regions were those predicted independently using two peak-calling algorithms. In uninfected cells, ~12,650 high-confidence open chromatin regions were identified. These mapped to ~8700 gene bodies, whose genes functionally controlled organelle synthesis and Th2 pathways (IL6, TSLP). These latter cytokines are preferentially secreted by RSV-infected bronchiolar cells and linked to mucous production, obstruction, and atopy. By contrast, in RSV infection, we identify ~1700 high confidence open chromatin domains formed in 1120 genes, primarily in introns. These induced chromatin modifications are associated with complex gene expression profiles controlling tyrosine kinase growth factor signaling and extracellular matrix (ECM) secretory pathways. Of these, RSV induces formation of nucleosome-free regions on TGFB1/JUNB//FN1/MMP9 genes and the rate limiting enzyme in the hexosamine biosynthetic pathway (HBP), Glutamine-Fructose-6-Phosphate Transaminase 2 (GFPT2). RSV-induced open chromatin domains are highly enriched in AP1 binding motifs and overlap experimentally determined JUN peaks in GEO ChIP-Seq data sets. Our results provide a topographical map of chromatin accessibility and suggest a growth factor and AP1-dependent mechanism for upregulation of the HBP and ECM remodeling in lower epithelial cells that may be linked to long-term airway remodeling.
Enhancement of Tetravalent Immune Responses to Highly Conserved Epitopes of a Dengue Peptide Vaccine Conjugated to Polystyrene Nanoparticles
Authors: Chan Yanqi , Jazayeri Seyed Davoud , Ramanathan Babu , Poh Chit Laa
Published: July 2020

Vaccination remains the major approach to the prevention of dengue. Since the only licensed live attenuated vaccine (LAV) lacked efficacy against all four serotypes, other vaccine platforms, such as synthetic peptide vaccines, should be explored. In this study, four multi-epitope peptides (P1–P4) were designed by linking a universal T-helper epitope (PADRE or TpD) to the highly conserved CD8 T cell epitope and B cell epitope (B1 or B2) against all four DENV serotypes. The multi-epitope peptides were conjugated to polystyrene nanoparticles (PSNPs) and four nanovaccines (NP1–NP4) were constructed. Mice immunized with NP1–NP4 elicited significantly higher titers of IgG and neutralizing antibodies when compared to immunization with naked P1–P4. The immune responses in mice immunized with peptide vaccines were compared with nanovaccines using ELISA, ELISPOT, and a neutralization test based on FRNT50. Among the four conjugated peptide nanovaccines, NP3 comprising the TpD T-helper epitope linked to the highly conserved B1 epitope derived from the E protein was able to elicit significant levels of IFN-γ and neutralizing antibodies to all four dengue serotypes. NP3 is a promising tetravalent synthetic peptide vaccine, but the selection of a more effective CD8+ T cell epitope and adjuvants to further improve the immunogenicity is warranted.
Vadose Zone Lag Time Effect on Groundwater Drought in a Temperate Climate
Authors: Wossenyeleh Buruk Kitachew , Verbeiren Boud , Diels Jan , Huysmans Marijke
Published: July 2020

An essential factor in the propagation of drought, from meteorological drought to groundwater drought, is the delay between a precipitation event and the groundwater recharge reaching the groundwater table. This delay, which mainly occurs in the vadose zone of the hydrological cycle, is often poorly studied. Therefore, this paper proposes a method for estimating the spatially distributed delay in the vadose zone using the kinematic wave approximation of Richards’ equation combined with the van Genuchten–Burdine and Brooks–Corey parametric model. The modeling was approached (1) using a detailed parametrization of soil and geological layers and (2) using lumped hydraulic and physical properties of geological layers. The results of both approaches were compared against the physically based flow model Hydrus-1D. This analysis shows that using a detailed parametrization of soil and geological layers results in good comparison, with a Nash–Sutcliffe efficiency of 0.89 for Brooks–Corey and 0.80 for van Genuchten–Burdine. The delay result of the Brooks–Corey model was incorporated into the groundwater recharge time series from 1980 to 2013 to analyze the effect of this delay on groundwater drought. The results show that the delay in the vadose zone influences groundwater drought characterization features such as the number, duration, and intensity of drought events.
Water Pollution in a Densely Populated Megapolis, Dhaka
Authors: Bashar Toriqul , Fung Ivan W.H.
Published: July 2020

Rapid urbanization has been a boon for industrial growth in Bangladesh, leading the Dhaka megapolis to become one of the least livable places in the world. These circumstances, however, have received little attention by policy makers and in academic research. Using mainly secondary data, this article explores the water quality of the river Buriganga that flows across Dhaka and identifies major sources of pollutants. While much of the article analyzes the sources and extent of pollution, it also points toward a great threat to public health from the presence of high levels of heavy metals, such as chromium, lead, and iron, as well as chemicals, including ammonia and phosphate. Moreover, the article recommends some policy changes that could potentially reduce pollution levels and boost water sustainability not only in Dhaka but also in other fast-growing cities in the least developed countries (LDCs).
Study of technological characteristics of the Health in gum® base for chewing gum
Authors: Blynskaya E. , Tishkov S. , Bueva V. , Alekseev K. , Alekseev V. , Dzhafarova T. , Mamedova D.
Published: July 2020

Medicated chewing gum is a convenient dosage form that allows to expand the range of medicines, ensure adherence of patients to the treatment and extend patent protection for well-known names of medicines. This article describes the technological properties of the Health in Gum® chewing gum base, which provides medicinal chewing gums with minimal addition of excipients by direct compression.
Subsequent measurement of intangible assets in the new federal accounting standard for public sector organizations
Authors: Druzhilovskaya Emilia
Published: July 2020

This article examines the regulations for the subsequent evaluation of intangible assets established by the new federal accounting standard for public sector organizations (including public health organizations in this sector). These regulations are analyzed in conjunction with the requirements of other regulatory documents on accounting. The author identifies the main problematic issues associated with the subsequent valuation of intangible assets of public sector organizations (including health organizations of the specified sector) and substantiates proposals for their solution.
Federal accounting standard for public finance “Intangible assets”: compliance with current legislation and IFRS OS
Authors: Aleynikova Marina
Published: July 2020

Starting from January 1, 2021, the Federal accounting standard for public finances “Intangible assets” is being introduced. The article focuses on the use of new approaches by public sector organizations to organize accounting (budget) accounting of intangible assets, as well as their correlation with the requirements of current legislation and the international public sector financial reporting standard IFRS OS 31 “Intangible assets”.
Audit of the effectiveness of expenditures on purchases of goods, works and services for municipal needs
Authors: Zatsarinnaya Elena , Georgadze Nana , Sergeeva Alina
Published: July 2020

An audit of the effectiveness of spending budgetary funds in the procurement sector to meet state and municipal needs is an important tool for identifying violations and determining the correct use of budgetary funds. Today, increasing the efficiency of using public funds is one of the most important tasks facing public authorities. The article discusses and analyzes the key points in the audit of the effectiveness of spending public funds in the procurement sector. The essence, content of performance audit and features of its implementation are revealed.
Controlling the effectiveness of purchasing activities of a research medical organization
Authors: Plaskova Nataliya
Published: July 2020

The article presents current trends in improving the system of controlling purchasing activities of a research organization in the healthcare industry. The successful functioning of research and development activities in the field of medicine and health care largely depends on its sufficient and timely provision of the necessary resources purchased from various domestic markets of raw materials, goods, services, and abroad. Not only should purchases themselves be optimized according to qualitative, quantitative, cost and time criteria, but it is also important to properly control their rational use and evaluate the effectiveness of funds aimed at providing resources for research activities. Improving the regulatory framework and regulation of procurement activities of research organizations contributes to improving the efficiency of the use of financial resources allocated for these purposes. In this regard, an urgent task is to analyze the current practice of implementing procurement procedures and identify factors that contribute to improving its efficiency and effectiveness of controlling the use of budget funds, both at the level of specific economic entities and at the macro level of managing socio-economic processes.
Labor of medical workers: paid in equity
Authors: Lebedev Viktor , Lebedeva Elena
Published: July 2020

The issues of legal regulation of incentive payments to medical and other personnel in the context of the spread of new covid-19 coronavirus infection are considered. Done comparative analysis of the RF Government decree No. 415 of April 2, 2020, which established additional incentive payments for special working conditions and additional workload for medical workers who provide medical care to citizens who have a new coronavirus infection and those at risk of Contracting a new coronavirus infection, as well as RF Government decree No. 484 of April 12, 2020, which established additional payments to specialists who work directly with patients for the period from April to June 2020, infected COVID-19 for performing particularly important work. The issues of using the term “actually worked time” in law enforcement practice are considered.
Ionic Species Affect the Self-Propulsion of Urease-Powered Micromotors
Authors: Arqué Xavier , Andrés Xavier , Mestre Rafael , Ciraulo Bernard , Ortega Arroyo Jaime , Quidant Romain , Patiño Tania , Sánchez Samuel
Published: July 2020

Enzyme-powered motors self-propel through the catalysis of
in situ
bioavailable fuels, which makes them excellent candidates for biomedical applications. However, fundamental issues like their motion in biological fluids and the understanding of the propulsion mechanism are critical aspects to be tackled before a future application in biomedicine. Herein, we investigated the physicochemical effects of ionic species on the self-propulsion of urease-powered micromotors. Results showed that the presence of PBS, NaOH, NaCl, and HEPES reduced self-propulsion of urease-powered micromotors pointing towards ion-dependent mechanisms of motion. We studied the 3D motion of urease micromotors using digital holographic microscopy to rule out any motor-surface interaction as the cause of motion decay when salts are present in the media. In order to protect and minimize the negative effect of ionic species on micromotors’ performance, we coated the motors with methoxypolyethylene glycol amine (mPEG) showing higher speed compared to noncoated motors at intermediate ionic concentrations. These results provide new insights into the mechanism of urease-powered micromotors, study the effect of ionic media, and contribute with potential solutions to mitigate the reduction of mobility of enzyme-powered micromotors.
Upregulation of Kiss-1 and Gpr54 Genes Expression in Pituitary of Male Rats Following the Central Administration of Neuropeptide Y
Authors: Azizi Vahid , Oryan Shahrbanoo , Khazali Homayuon , Hosseini Abdolkarim
Published: July 2020

Introduction: The neuropeptide Y (NPY) in the neural circuits of the hypothalamus has a stimulating effect on reproductive activities in mammals. Kisspeptin (KiSS1) is a quintessential neurotransmitter in the reproductive axis which directly stimulates gonadotropin-releasing hormone neurons in the hypothalamus. The distribution of KiSS1 expressing cells in the pituitary was described previously. Despite earlier reports showing the KiSS1 receptor, G-protein coupled receptor 54 (GPR54) expression in the pituitary, the potential physiological roles of kisspeptin at this gland have remained obscure. Accordingly, this study investigated the role of NPY on the relative expression of Kiss1 and Gpr54 genes in the pituitary gland in male Wistar rats. Methods: In general, 20 male Wistar rats weighing 200-250 g in 4 groups (5 in each group) received saline, NPY (2.3 nM), BIBP3226 (NPY receptor antagonist, 7.8 nM), and NPY+ BIBP3226. Then, they received the simultaneous injection of these molecules through the third ventricle of the brain. Finally, the relative mean expressions of Kiss1 and Gpr54 genes in the anterior pituitary were quantitatively analyzed by the real-time polymerase chain reaction. Results: The central injection of NPY increased the relative mean expressions of Kiss1 and Gpr54 genes in the pituitary gland compared to the control group although the injection of BIBP3226 eradicated these effects. However, the gene expression of Gpr54 in the rats receiving NPY coupled with BIBP3226 in hypophysis in comparison to the group receiving only NPY demonstrated a significant reduction (P<0.05). Conclusion: Overall, the central injection of NPY stimulated the gene expression of Kiss1 and Gpr54 in the pituitary gland.
Tris (2-aminoethyl) Amine Functionalized Nanoporous Silica SBA-15 as a Potential Drug Carrier for Citalopram
Authors: Dalayi Fatemeh , Hajiaghababaei Leila , Badiei Alireza , Boorboor Azimi Elham , Ganjali Mohammad Reza , Mohammadi Ziarani Ghodsi
Published: July 2020

Introduction: Ordered nanoporous silica such as SBA-15 has a great potential for application in controlled drug release systems. Chemical modification of the silanol groups of SBA-15 allows better control over drug loading and release. Therefore, tris(2-aminoethyl) amine-functionalized mesoporous silica SBA-15 was evaluated as a potential carrier for the delivery of citalopram. Methods: Tris (2-aminoethyl) amine-functionalized SBA-15 was synthesized and characterized by various methods. Citalopram was loaded on the functionalized SBA-15 and drug release into simulated body fluid (SBF) solution and phosphate buffers was investigated. Results: The optimal condition for loading of the citalopram was obtained at pH = 9 after stirring for 5 minutes. The release profile of citalopram was monitored in phosphate buffers with three different pH values of 5, 7, and 8. A faster release rate at lower pH value was observed, suggesting a weaker interaction because of the protonation of the amino group of the functionalized SBA15. The average release rate of citalopram from each gram of functionalized SBA-15 was 12 µg h-1 in the SBF. Conclusion: The results showed that loading amount and release rate of citalopram depended on pH value and the release process showed a very slow release pattern. Therefore, tris (2-aminoethyl) amine-functionalized SBA-15 is a suitable carrier for controlled release of citalopram and has a great potential for disease therapy.
АНАЛІЗ ГОСПОДАРСЬКОЇ ДІЯЛЬНОСТІ ТРУБНИХ ПІДПРИЄМСТВ, ЩО ВХОДЯТЬ ДО ОБ’ЄДНАННЯ "УКРТРУБОПРОМ" ЗА ПІДСУМКАМИ ДЕВ’ЯТИ МІСЯЦІВ 2019 РОКУ
Authors: Ksaverchuk Leonyd P. , Grynev Anatoliy F. , Korol Radomyr M. , Myronenko Mykola A.
Published: July 2020

Мета. Проаналізувати особливості розвитку металургійних трубних підприємств України, які перебувають під егідою об’єднання "Укртрубопром" за підсумками дев’яти місяців 2019 року. Показати тренди розвитку металургійної галузі нашої країни на зовнішньому та внутрішньому ринках. Обґрунтувати пропозиції щодо комплексу заходів для подолання негативних тенденцій на заводах трубної галузі України. Методика. При написанні статті використовувався метод співставного аналізу для обґрунтування рекомендацій щодо подолання негативних явищ у трубній галузі України. Результати. В статті проведено аналіз розвитку економічних процесів у трубній галузі держави за останні дев’ять місяців 2019 року. Подано рекомендації щодо подолання негативного тренду розвитку трубних підприємств на внутрішньому та зовнішньому ринках, які перебувають під егідою об’єднання "Укртрубопром". Наукова новизна. Підтверджено важливість застосування на практиці методів теорії управління, зокрема методу співставного аналізу. Це дозволило запропонувати низку заходів, спрямованих на комплексне вирішення існуючих у трубній галузі України проблем. Практичне значення. Викладена у цій статті інформація буде корисною широкому загалу наукової спільноти, а також виробничникам-практикам, які цікавляться питаннями загального тренду розвитку трубної галузі України.
МОДЕЛИРОВАНИЕ ПРОЦЕССА ЗАМОРАЖИВАНИЯ ГРАВИЙНЫХ ФИЛЬТРОВ ИСПОЛЬЗУЕМЫХ В ГОРНЫХ ТЕХНОЛОГИЯХ
Authors: Sudakov Andrii , Dziuba Sеrhii , Dreus Andrii , Lysenko Кaterina
Published: July 2020

Цель. Обоснование методов математического моделирования для анализа теплофизических характеристик в технологиях использования нового типа низкотемпературных гравийных фильтров.Методика. Анализ современных методов математического моделирования процессов тепломассообмена в гравийных фильтрах для горного производства позволил определить длительность выдержки фильтра в морозильной камере, что необходимо для обоснования энергозатрат технологии.Результаты. Проведен анализ теплофизических аспектов технологии использования нового типа низкотемпературных гравийных фильтров. Для обеспечения надежной работы данных фильтров необходимо выполнение оценки параметров тепломассобменных процессов в теле гравийных фильтров при установке их в скважины. Представлена математическая модель для исследования тепломассопереноса в пористой среде гравийного фильтра при изготовлении его по низкотемпературной технологии и результаты расчета температурных полей в теле фильтра с учетом фазового превращения вяжущего вещества.Научная новизна. На основе анализа современных методов математического моделирования разработана модель теплофизического процесса в теле гравийных фильтров при их установке в скважины с учетом тепло и влагопереноса в пористой среде фильтров при изготовлении их по низкотемпературной технологии.Практическая значимость. Заключается в усовершенствованные технологий изготовления низкотемпературных гравийных фильтров, предназначенных для эксплуатации в условиях горного производства на основе анализа полученных результатов расчета температурных полей в теле фильтра с учетом фазовых превращений вяжущего вещества и влагопереноса.
EXPERIMENTAL ESTIMATION OF MAXIMAL DUCTILITY AND FLOW CURVES OF TITANIUM ALLOYS WITH HOT-TORSION TESTS
Authors: Medvediev Мikhailo , Frolov Yaroslav , Andreiev Vitalii , Bobukh Oleksandr , Vovk Аnastasiya
Published: July 2020

Purpose. The purpose of this work is to clarify the temperature-deformation modes of pressing pipes of titanium alloys (VT1-0, PT-7M, VT-14, VT-15, TS-5 and TS-6) and to determine the regression coefficients of the Hansel-Spittel equation by investigating plasticity and the deformation resistance during hot rotation of the specimens.Methodology. Studies on torsion were performed on a torsion test machine with a horizontal electronic force meter, with a maximum torque of 100 H × m, temperature. The maximum temperature of the test specimens was 1250 °C. Active capture of the test machine has a smooth rotation control from 5 to 200 rpm. Applying specimens with different aspect ratio to the length of the workpiece obtained a range of change of strain rates from 0.25 to 20 с-1.Findings. The main results of the study should be considered experimentally determined curves of the torque dependence on the angle of rotation of the sample to change the resistance of deformation of the metal, which allowed to clarify the temperature interval of maximum ductility during pressure treatment for alloys VT1-0, PT-7M, VT-14, VT-15, TS-5 and TS-6. Based on the data obtained on the deformation resistance, the coefficients of the Hansel-Spittel equation, which can be used to quantify the resulting stress in numerical simulation using the finite element method, have been statistically calculated.Originality. The data on experimentally determined regularities of influence of temperature-deformation modes of torsion on the change of the value of deformation resistance, which is characteristic of conditions of hot pressing of pipes, have been further developed. This allows to predict the power parameters of the deformation process, as well as to select the press equipment and improve the productivity of the press line.Practical implications. Studies on torsion have allowed to determine rational temperature-speed parameters of the process of pressing pipes from titanium alloys VT1-0, PT-7M, VT-14, VT-15, TS-5 and TS-6, for capacities of Ukrainian enterprises.
ИНТЕНСИФИКАЦИЯ ПРОЦЕССОВ МЕХАНИЧЕСКОГО ВЗАИМОДЕЙСТВИЯ ИНСТРУМЕНТА С ЗАГОТОВКОЙ ПРИ ВЫПОЛНЕНИИ ВЫСОКОТОЧНЫХ И ЭНЕРГОЕМКИХ ТЕХНОЛОГИЧЕСКИХ ОПЕРАЦИЙ МЕТОДАМИ ДАВЛЕНИЯ И РЕЗАНИЯ
Authors: Uchytel A. , Malinovskii Yu. , Panchenko H. , Dvoretskyi D. , Omelchenko E. , Datsenko S.
Published: July 2020

Цель: исследовать динамику взаимодействия поверхностных слоев заготовки с инструментом при выполнении высокоточных и энергоемких технологических операций по обработке металлов давлением и механической обработки резанием, а также выполнить поиск методов интенсификации указанных рабочих процессов, позволяющих повысить качество готовых изделий и понизить энергоемкость технологических процессов.Методика. Для исследований принята модель, в которой инструмент условно представлен в виде жёсткого штампа, а деталь представлена в виде податливой плоской полосы при различных условиях опирания наружных слоев обрабатываемых изделий. В работе использована гипотеза о том, что нелинейное трение является источником самовозбуждающихся колебаний между инструментом и деталью, которые приводят к возникновению завышенных усилий резания и получению обработанных поверхностей, в ряде случаев, не достаточно высокого качества. Построены математические модели для описания деформированных поверхностных слоёв детали под воздействием критических нагрузок. Рекомендованы методы повышения эффективности обработки изделий, которые сводятся к применению наложения вибраций с определёнными амплитудами и частотами, причём, воздействие этих вибраций сводится к выводу и решению уравнений, совпадающих по форме с уравнениями для самовозбуждающийся колебаний.Научная новизна заключается в том, что для описания процесса волочения на волочильных установках и процесса механической обработки изделий на металлорежущих станках применена одна и та же расчетная модель и использован один и тот же математический аппарат. Для интенсификации рассматриваемых технологических процессов рекомендовано использовать наложение вибрации с оптимальной настройкой по частоте и амплитуде.Практическая ценность работы заключается в том, что указанный метод интенсификации рабочих процессов при оптимальном выборе параметров наложенных вибраций может быть успешно применен при волочении холодной и горячей прокатке, штамповке, обработке фрезерованием, строганием, точением, дроблением измельчением и бурением горных пород и других технологических процессов.
alusivo y lo elusivo en el discurso: Carta de Elisa Carrió a los argentinos (Clarín, 12 de mayo de 2015)
Authors: Fernández María del Rosario
Published: July 2020

Este artículo aborda una carta abierta a los argentinos escrita por Elisa Carrió. En ella hemos profundizado nuestra teoría acerca de los procesos alusivos/elusivos que se ponen en juego
sentidos del trabajo en prisión. Prácticas laborales en Unidades Penitenciarias de la Provincia de Santa Fe
Authors: Routier María Eva
Published: July 2020

Nos proponemos en este escrito describir las prácticas laborales en las prisiones de la Provincia de Santa Fe, a partir de un proceso de reconocimiento de las distintas dimensiones que las conforman. Sosteniendo que la marcha del trabajo, tanto dentro como fuera de la prisión, contribuye a dar forma al encarcelamiento en distintos momentos históricos (Matthews, 1999), iniciamos este artículo retomando un conjunto de trabajos que desde la criminología crítica han dado cuenta de la relación entre cárcel y modos de producción (Pavarini, 2010). Continuamos nuestro recorrido buceando por los sentidos acerca de la funcionalidad y garantía de trabajo en las cárceles argentinas hallados en las normativas vigentes a nivel nacional y provincial en torno a la Ejecución de la Pena Privativa de la Libertad. Finalmente, nos detendremos en la descripción etnográfica de un conjunto de prácticas laborales en la Unidad Penitenciaria Nº1 de la Provincia de Santa Fe, en las cuales empezamos a reconocer un complejo entramado de sentidos vinculados a los niveles anteriormente mencionados.
La diasporización de los hijos: identificaciones y relaciones inter-generacionales en familias bolivianas y paraguayas en Buenos Aires
Authors: Gavazzo Natalia
Published: July 2020

En este artículo se examinarán diversas identificaciones que se construyen en la generación de jóvenes argentinos hijos de inmigrantes bolivianos y paraguayos en Buenos Aires. Se parte de que las relaciones inter-generacionales en las familias migrantes son centrales en el contexto de comunidades parentales transnacionales que se relacionan mediante representaciones y prácticas compartidas. Se atenderá, entonces, a la construcción de identidades diaspóricas entre los descendientes como grupo específico a partir de las relaciones que construyen con sus padres, abuelos y hermanos, y también con sus familias extendidas a ambos lados de las fronteras nacionales.
La política en disputas urbanas. Una revisión sobre debates antropológicos, bifurcaciones epistémicas y dualismos analíticos
Authors: Quevedo Cecilia Mercedes
Published: July 2020

El artículo desarrolla una revisión bibliográfica sobre la acción política popular en disputas urbanas metropolitanas en el periodo entre 2004 y 2014. Se presentan dos ámbitos empíricos de teorización antropológica: urbanizaciones de villas y ocupaciones de tierras en el Área Metropolitana de Buenos Aires. El argumento plantea una bifurcación epistemológica cuando se trata de comprender la práctica política en movilizaciones por el acceso al hábitat popular. El objetivo del trabajo organiza críticamente un estado del arte que revisita el debate sobre clientelismo político y explora cruces con “el derecho a la ciudad”, que es el nuevo paradigma desde el cual se leen las disputas urbanas tradicionales.
El Baño de Mandinga (Rosario, Santa Fe, Argentina, 1910): Arqueología de una tierra de nadie.
Authors: Volpe Socorso , Fernetti Gustavo
Published: July 2020

Rosario, en su expansión de finales del siglo XIX, generó espacios que permanecieron como relictos hasta hoy. Las poblaciones residentes eran marginadas, a la espera del trabajo o de la basura que les permitía sobrevivir: la prensa de la época solía ser sarcástica con respecto a estos grupos, considerados un obstáculo para la civilización.

Una de estas crónicas posibilitó acercarse a uno de esos lugares “insalubres”: el Baño de Mandinga. Articulando historia y arqueología, el objetivo de este trabajo fue iniciar una serie de estudios sobre las poblaciones que la historia de Rosario por lo general ha ignorado.
Reseña del libro "La política afectada. Experiencia, trabajo y vida cotidiana en Brukman recuperada"
Authors: Vitali Sofía
Published: July 2020

Reseña de libro
Límites y alcances en el reconocimiento de proyectos de arte y transformación social en Argentina: el teatro comunitario en las políticas culturales públicas (2006-2018)
Authors: Sánchez Salinas Romina , Mercado Camila
Published: July 2020

En este trabajo realizamos un primer abordaje acerca del reconocimiento de proyectos culturales de base comunitaria que apuestan por el arte y la transformación social, fenómeno que se ve reflejado en la consolidación de programas de apoyo específicos al área. Nos centraremos en el caso del teatro comunitario, una práctica que cuenta con una larga trayectoria en nuestro país y que concibe al Estado como un actor clave en la disputa por el reconocimiento simbólico y por la distribución de recursos económicos. Estos actores ocupan un rol relevante en la conformación de un ámbito que resalta el potencial transformador de las artes, siendo asimismo articuladores de muchas de las demandas generadas en el sector.

Partimos de una concepción del campo cultural como un terreno de disputas en torno al poder de definir pertenencias, reconocimiento y acceso a recursos donde los usos del concepto de “cultura” son diversos y a veces conflictivos. En este sentido, el teatro comunitario ha disputado espacios de reconocimiento por parte del Estado que se han materializado en distintas líneas de apoyo. Por lo tanto, nos interesa indagar en las disputas, conflictos, negociaciones que se desencadenan a partir de estas interacciones entre actores comunitarios y agentes estatales, así como en las apropiaciones y usos del concepto por parte de los programas.
Organizational Communication Patterns In Disaster Management
Authors: Fitriani Fitriani
Published: July 2020

The research objective is to find out the right communication patterns used in disaster management by organizations. This research uses descriptive qualitative research methods with literate data collection techniques. The results of this study indicate that organizations can use star communication patterns and chain communication patterns, Star communication patterns are used to communicate in general, where superiors directly communicate with subordinates and subordinates directly communicate to superiors without intermediaries from others. For the chain pattern in the organization is used to provide information that is announcement from one division to all employees that must be submitted through the division. Communication from superiors to subordinates in the form of work or task instructions. Communication from subordinates to superiors is communication in the form of work reports, information about disasters and advice.
Self-limiting processes in thermal atomic layer etching of nickel by hexafluoroacetylacetone
Authors: Basher Abdulrahman H. , Hamada Ikutaro , Hamaguchi Satoshi
Published: July 2020

In thermal atomic layer etching (ALE) of Ni, a thin oxidized Ni layer is removed by a hexafluoroacetylacetone (hfacH) etchant gas at an elevated surface temperature, and etching ceases when a metallic Ni surface appears (self-limiting step). However, atomistic details of the self-limiting step was not well understood. With periodic density-functional-theory calculations, it is found that hfacH molecules barrierlessly adsorb and tend to decompose on a metallic Ni surface, in contrast to the case of a NiO surface, where they can form volatile Ni(hfac)2. Our results clarify the origin of the self-limiting process in the thermal ALE.
Predicting performance of thermal-electrical cycles in pyroelectric power generation
Authors: Baba Masaaki , Ejima Masahiro , Murayama Ichiro , Fukuda Tatsuo , Tanaka Hirohisa , Sekino Tohru , Kim Yoonho , Yamada Noboru , Takeda Masatoshi
Published: July 2020

A method is proposed to predict the power generation performance of a pyroelectric generator (PEG) for waste-heat recovery systems in which an external electric field is applied to a ferroelectric material in synchrony with rapid temperature changes. The net generated energy density N
D of the PEG at any temperature and electric field is predicted for two thermal-electrical cycles (including the Olsen cycle). This is done by approximating the dependence of the polarization density on temperature and electric field using hysteresis loop measurements. The difference between the predicted and measured values of N
D was less than 15%. This method could be used to screen promising candidate materials for PEGs.
ENTREVISTA COM O PROF. DR. LAURO FREDERICO BARBOSA DA SILVEIRA
Authors: Rodrigues Gilberto César Lopes
Published: July 2020

Um dos objetivos da revista eletrônica Kínesis é apresentar pesquisadores que tenham seu nome vinculado a pesquisas sobre temas filosóficos contemporâneos. Para abrilhantar a edição inaugural e especial da revista Kínesis, apresentamos uma entrevista com um dos professores que, além de pesquisar temas filosóficos contemporâneos, fortemente trabalhou para a instalação do programa de pós-graduação em Filosofia na Faculdade de Filosofia e Ciências do campus da UNESP de Marília.
EDITORIAL
Authors: Moraes João Antonio de , Ferreira Rafael dos Reis
Published: July 2020

Temos a satisafação de apresentar mais uma edição da Kínesis - Revista de Estudos dos Pós-Graduandos em Filosofia da UNESP. A presente edição conta com 27 artigos de pós-graduandos dos principais centros de pós-graduação em Filosofia do país. O presente número foi o resultado de um trabalho sério e criterioso da Comissão Editorial da Kínesis, do corpo qualificado da Comissão Científica e de pareceristas ad hoc. Queremos agradecer a todos pelo respeito a Kínesis.
SOBRE A CRÍTICA FILOSÓFICA DE ADORNO AO TÉDIO E O SEU REFERIDO CONCEITO EM LARS SVENDSEN
Authors: Silva Felipe Resende da
Published: July 2020

Este artigo está dividido em duas partes, cada qual contendo o seu objetivo distinto: na primeira parte, busca-se traçar um breve panorama sobre a atenção de Adorno em torno do problema do tédio na sociedade administrada. Na segunda parte, serão analisados alguns aspectos de seu conceito em Lars Svendsen (visto que Adorno não o desenvolveu analiticamente). Como veremos ao longo do desenvolvimento deste artigo, lançar os olhos sobre essa patologia social da modernidade significa realizar um diagnóstico do estado geral da cultura, onde o trabalho, o tempo livre e os objetos culturais se desviam do caminhoemancipatório do homem. A perda do teor ético dessas três instâncias acarreta em um fenômeno de deformação crônica sobre os indivíduos, a negar-lhes principalmente um sentido para a própria existência e a capacidade de realizarem experiências (Erfahrung). Assim, a própria ideia de progresso é posta em xeque, na medida em que em uma sociedade portadora de todos os elementos necessários para a emancipação humana toma o caminho oposto a esta, desumanizando os indivíduos das mais variadas maneiras possíveis. O problema do tédio, assim, aponta para uma mal resolvida dialética do progresso, no sentido da auto-realização humana estar obstruída pelo processo de integração social.
JUSTIÇA EM PLATÃO E ROUSSEAU: A LEI GRAVADA NO CORAÇÃO DOS CIDADÃOS
Authors: Bezerra Gustavo Cunha
Published: July 2020

Procuro analisar neste artigo a relação entre o pensamento de Platão e Rousseau quanto à concepção e condições que tornem possível a justiça. O recurso à dissimulação, largamente tratado por Rousseau em suas obras, permite a aparência da justiça ao injusto, o que torna a injustiça mais vantajosa do que a justiça. Esse tema é levantado a partir da passagem sobre o anel de Giges na República de Platão e retomado por Rousseau, que vê no hipotético uso desse anel a possibilidade de conhecer o íntimo das pessoas e, assim, julgá-las de forma justa. Dessa maneira, o “coração dos homens” é o lugar privilegiado ao qual Rousseau desejaria ter acesso para curar a sociedade. Ao pensar as formas saudáveis e prósperas de sociedade, uma preocupação central em Rousseau é o íntimo dos cidadãos. Influenciado pelas repetidas leituras da República de Platão e pela grande admiração que sente por essa obra, Rousseau defende uma educação que atinja o interior dos indivíduos – tal como o pensador grego – como única forma de se instaurar uma sociedade justa.
DITAMES DA RETA RAZÃO: ESTADO DE NATUREZA E SOCIABILIDADE EM PUFENDORF
Authors: Lucena André Queiroz de
Published: July 2020

Trata-se de apontar, a partir das considerações sobre o estado de natureza e sociabilidade em De jure naturae et gentium de Pufendorf, os elementos que reforçam o papel da recta ratio na preservação do gênero humano. De fato, pela atenção contínua a seus ditames, pode o jurisconsulto refutar a hipótese hobbesiana do estado de guerra e postular a natureza sociável do Homem.
RAZÃO E (I)MORALIDADE
Authors: Corbanezi Eder
Published: July 2020

O objetivo deste artigo é – a partir da Dialética do Esclarecimento, de Adorno e Horkheimer – mostrar por que, embora o pensamento de Kant represente a forma mais acabada do projeto moderno de racionalidade, não é ele que leva, no domínio moral, o esclarecimento às últimas conseqüências, mas sim Sade e Nietzsche. Veremos como o diálogo entre filosofia e literatura é fundamental nesse diagnóstico.
HUME E LEIBNIZ: ENTRE O INATISMO E O EMPIRISMO
Authors: Araújo Suzane da Silva
Published: July 2020

Nosso texto busca fazer uma análise das hipóteses levantadas, para as explicações acerca da origem das ideias e de suas conexões, pelo filósofo David Hume (um dos principais representantes da corrente de pensamento empirista na modernidade), e, Gottfried Leibniz, que, junto com Descartes, apresenta, em suas obras, as principais teorias da corrente de pensamento racionalista. Para isso, encontramos a base de nossa proposta na Investigação sobre o entendimento humano, de Hume, e nos Novos ensaios sobre o entendimento humano, de Leibniz. Como sabemos, a obra de Leibniz aqui referida é uma tentativa de refutação do Ensaio acerca do entendimento humano, de Locke, o que pode nos levar a fazer algumas referências ao precursor de Hume, e, também, a René Descartes, uma vez que o Ensaio de Locke foi escrito com o objetivo de combater o cartesianismo, e, mais diretamente sua teoria de que nossas ideias seriam inatas. Embora nosso texto envolva quatro filósofos, a preocupação que nos move recai sobre Hume e Leibniz, servindo-nos Locke e Descartes, apenas, como pontos de apoio, devido o entrecruzamento entre suas teorias.
BERGSON E A EVOLUÇÃO DA VIDA
Authors: Gomes Ana Beatriz Antunes
Published: July 2020

Bergson sustenta que a ordem vital é essencialmente um processo inesgotável de criação. A vida é um aspecto expressivo do tempo que, por sua vez, é autônomo e independente do espaço e do sujeito, bem como irredutível às funções quantitativas de medida. Trata-se da natureza qualitativa e virtual de toda diferença que devém natureza viva por uma atualização irresistível. Contudo, não é menos verdade que a vida se apresenta comumente menos em sua essência movente do que por meio de seus acidentes de percurso, recortando individualidades e se hipnotizando em generalizações ou repetições diversas, que imitam antes a ordem física, quiçá a geométrica. Pretendemos nesse Artigo acompanhar o movimento do impulso vital - responsável por conduzir o processo de diferenciação de virtual à atual - em sua força explosiva, em suas nuances, obstáculos encontrados e sua inevitável superação ao compor novidades radicalmente imprevisíveis. Desse modo, compreenderemos que o traço característico da evolução biológica não é a capacidade de adaptação das formas vivas ao meio que lhes impõe condições de existência, mas, sim, sua intrínseca potência criadora que prolifera composições entre a matéria e o espírito - direções diversas e até extremas de duração.
A MEGAMÁQUINA POLÍTICA: PODER, RESISTÊNCIA E DESERÇÃO
Authors: Alvim Davis Moreira
Published: July 2020

Partindo da investigação dos conceitos de “molar” e “molecular” no pensamento de Gilles Deleuze e Félix Guattari, o artigo busca desenvolver a ideia de megamáquina política. Trata se de um conjunto complexo de forças que entretém relações com o poder, as resistências e a soberania que só pode ser desvendado por meio da distinção entre macro e micropolíticas.
A EXPRESSÃO PERCEPTIVA DA POESIA NA METAFÍSICA DA CARNE
Authors: Ferreira Gilmar Leite
Published: July 2020

O artigo reflete sobre a expressão perceptiva da poesia na metafísica da carne. Nele, busca se a compreensão do entrelaçamento corpo e poesia transformando a existência, onde a palavra poética se mostra de maneira encarnada. O trabalho reflete a revelação do corpo por intermédio da poesia se mostrando ao mundo por meio da experiência estética e da criação poética. Nele, mostra-se a compreensão entre a arte poética e o corpo, num diálogo sensível, que ontologicamente se revela ao mundo na expressão criativa, na linguagem, na estética, expandindo e dando sentido à existência, sempre em busca da elaboração de sentidos e na construção de novos significados. Tendo a filosofia de Merleau-Ponty como aporte teórico, os passos dados no artigo têm na experiência estética a expressão perceptiva da poesia na metafísica da carne, mostrando o universo da criação poética, a qual revela a existência por meio da palavra encarnada e traz novas maneiras de perceber-se e de perceber o mundo.
EDITORIAL
Authors: Moraes João Antonio de , Ferreira Rafael dos Reis , Valerio Raphael Guazzelli , Pilan Fernando César
Published: July 2020

É com satisfação que apresentamos mais uma edição da Revista Kínesis - Revista de Estudos dos Pós-Graduandos em Filosofia da UNESP. A presente edição conta com 11 artigos de instituições de Pós-Gradução de todo o país. Mais uma vez a Kínesis é coroada com bons artigos, qualificados pelo criterioso Conselho Científico e pareceristas ad hoc. Nós editores fechamos o volume 4 com uma trajetória de muito esforço e dedicação, refletidas do reconhecimento da Kínesis no meio acadêmico dos Pós-Graduandos no Brasil e no exterior.