bluuebunny/crossref_metadata_2025 huggingface dataset:
Becoming an African Techpreneur: Geopolitics of Investments in “Local” Kenyan Entrepreneurship
Authors: Okune Angela , Mutuku Leonida
Published: September 2023

Entrepreneurs in Kenya are heterogenous, with diverse backgrounds, career goals, and personal histories. However, during five years of working long hours at the iHub, Nairobi’s co-working space for technology entrepreneurs, we observed the emergence of the trope of the “Kenyan Techpreneur” that came to be latched onto by the state, development aid, and philanthropic sectors and gained its own circulatory power. Through an analysis of the figure of the Kenyan “Techpreneur” and its production in Nairobi, this paper reveals how imperial logics and structures continue to underpin apparently independent initiative, pointing to the limits of thinking in simple binary terms and to a need for inventive, cosmopolitan constructs of Kenyan entrepreneurism. In recent years, Kenyans figured as Techpreneurs have contested the narrow construction of its parameters, which ironically appear to disproportionately benefit non-Africans working in the Kenyan tech sector. Describing some of the quotidian ways that transnational geopolitics and capital continue to heavily shape what happens within the bounds of the nation-state and the “local” Kenyan tech scene, we seek to emphasize how the local is in fact heavily tied up with enduring imperial formations of neoliberal development. This is an important prompt for a global STS to bring new, more complex subjects into relief.
Translating STS in China. Disciplinary Struggles and Future Prospects
Authors: Santos Gonçalo D. , Sharif Naubahar , Xing Jack Linzhou
Published: September 2023

This article analyzes a debate in Mainland China over how to designate and integrate the international field of STS (science and technology studies) in Chinese academia. Emerged at the turn of the millennium, this debate confirmed the increasing hold of STS in China, but it also revealed significant tensions regarding the general orientation and the place of the field in Chinese academia. These tensions reflect not only larger contradictions found in other globalized local instantiations of STS but also Chinese specificities. To understand both dimensions, this article approaches the rise of STS in China as a creative process of translation mediated by context-specific globalized struggles and negotiations. This approach builds on Asia-focused postcolonial discussions of translational practices to capture some of the distinctive features of the field of STS in China, including the strong influence of the Marxist tradition, the continuing hold of modernist-positivist approaches, and the strong control exercised by the party-state on academia. We use the Chinese example to highlight the translational diversity of the global STS project and to raise general questions about the future of STS across borders in the twenty-first century.
Moisture susceptibility of waste ceramic tiles modified asphalt mixtures
Authors:   Department of Civil Engineering, Confluence University of Science and Technology, Daniel Oguntayo , Olumide Ogundipe ,   Department of Civil Engineering, Ekiti State University, Jemimah Daikwo ,   Department of Civil Engineering, Landmark University, Festus Adeyemi ,   Department of Civil Engineering, Ajayi Crowther University,, Oluwasegun Aladegboye ,   Department of Civil Engineering, Landmark University
Published: September 2023

Waste ceramic tiles have been recognized as viable in producing asphalt mixtures. However, the primary concern is the assurance of its durability, especially in terms of moisture damage. Therefore, this research aims to investigate the moisture susceptibility of asphalt mixtures incorporating waste ceramic tiles (WCT). The coarse aggregates of 25 mm size were partially replaced with WCT at 0%-50% proportions. The Marshall Method of mix design was used to calculate the optimum bitumen content (OBC) at various levels of WCT replacement. Utilizing the retained strength index (RSI) and tensile strength ratio (TSR) tests, the moisture susceptibility of the mixes compacted at OBC was assessed. The results indicate that the continuous increase of WCT leads to decreased TSR and RSI values. The RSI ranges from 91.10%-81.90%, 74.91%-61.07% and 47.89%-41.05% at 1, 3, and 7-day curing, respectively. The TSR ranges from 89.27-74.73%, 71.48-63.81% and 58.02-46.79% at 1, 3, and 7-day curing, respectively. Nevertheless, it was determined that the WCT-modified asphalt mixtures met the TSR and RSI standards for asphalt mixtures with satisfactory moisture resistivity performance at 1 and 3 days of curing. For satisfying performance of WCT-modified asphalt mixtures, the study recommends an optimum proportion of 30% WCT.
Treatment of oncological and hematological diseases in HIV infection
Authors: Lushchevich S. V. , Litvinov V. D.
Published: September 2023

Oncological and hematological diseases associated with HIV infection continue to cause discussions among foreign and domestic researchers, clinicians, doctors, medical workers. The ongoing world globalization and modernization, environmental degradation have a detrimental effect on the health of citizens, which can be seen in virus mutations, high morbidity and a decrease in the social level in the Russian Federation and in the world. Oncological and hematological diseases associated with HIV infection are growing in the Russian Federation, but scientists do not stop at the results achieved, improving methods, treatment and therapy. As part of this study a statistical analysis of oncological and hematological diseases associated with HIV infection for 3 years (2019–2021) in Russia is carried out in order to trace the percentage of the medicine’s level, treatment’s effectiveness and deaths. A detailed analysis shows the decrease in deaths from HIV infection which pays attention the work of specialists in the Russian Federation.

   The purpose of this study is to identify a key method for the treatment of oncological and hematological diseases in HIV infection in Russia.

   The objective is to study the effectiveness of existing methods of treatment.

   Research methods – clinical, functional, microbiological and morphological.
Immune thrombocytopenia in the aspect of multiple primary neoplasms
Authors: Vardanyan R. V. , Zakharov S. G. , Mitina T. A. , Zeynalova P. A. , Chuksina Yu. Yu. , Zakharova A. V.
Published: September 2023

Multiple primary malignant neoplasms (MPMNs) is a complex process in which the development of 2 or more neoplasms simultaneously or after a certain interval is observed. MPMNs develop independently from each other within one or more organs. Many etiopathogenetic factors can cause MPMNs. Numerous studies have been conducted to study the effect of T-cell immunity on the development of this pathology. Today, there is a steady upward trend in the prevalence of mpmns, which, on the one hand, is due to more effective methods of early diagnosis, an increase in patient overall survival, and early antitumor therapy (chemotherapy, radiation therapy), on the other hand, this trend may be associated with pathology of T-regulatory cellular immunity. T-regulatory cells play a strategic role in the development of immune homeostasis, and their function is closely related to the occurrence of a wide range of pathologies, including autoimmune diseases and malignant neoplasms. The article presents a clinical case of a patient with a confirmed diagnosis: mpmn, immune thrombocytopenia (idiopathic thrombocytopenic purpura). On prednisolone therapy, remission was achieved for 2 metachronous tumors and a complete hematological response for immune thrombocytopenia was obtained. there were no signs of hemorrhagic syndrome and complications during prednisone therapy. It is planned to continue monitoring the patient for metachronous tumors by a hematologist, an oncologist at the place of residence, as well as at the center for orphan diseases of the Moscow Regional Research Clinical Institute named after M. F. Vladimirsky with control of platelets and general condition.
Telomere length of various blood and bone marrow cells in patients with aplastic anemia
Authors: Luchkin A. V. , Mikhailova E. A. , Galtseva I. V. , Fidarova Z. T. , Abramova A. V. , Davydova Yu. O. , Kapranov N. M. , Nikiforova K. A. , Kulikov S. M. , Parovichnikova E. N.
Published: September 2023

Background. Aplastic anemia proceeds with bone marrow failure and is associated with immunological suppression of normal blood stem cells’ proliferation, which lead to bone marrow aplasia. autoimmune aggression and internal defects of blood stem cell that cause abnormal hematopoiesis are being actively studied. An important role in the pathogenesis of the aplastic anemia is played by instability of telomere length (TL). determination of the initial TL makes it possible to clearly differentiate between the aplastic anemia and dyskeratosis congenita. also, it helps to identify the group of patients with short telomeres for prediction of therapy response.

   Aim. To investigation the TL of various blood and bone marrow cells in patients with aplastic anemia before treatment.

   Materials and methods. The group of patients with aplastic anemia was investigated (n = 45). blood donors (n = 32) and bone marrow donors (n = 10) of different ages were included in the reference group. adult patients with dyskeratosis congenita (n = 5) were included in the comparison group. Relative and absolute tl was identified in peripheral blood and bone marrow mononuclear cells, monocytes, lymphocytes by flow-FISH technique (combination of flow cytometry and fluorescence in situ hybridization).

   Results. Relative and absolute TL was comparable in different blood and bone marrow cells in patients with aplastic anemia before treatment. TL in peripheral blood and bone marrow mononuclear cells wasn’t significantly differed in groups of patients with aplastic anemia and healthy donors. Telomeres in patients with dyskeratosis congenita were identified as “ultrashort” and were significantly shorter than in patients with aplastic anemia.

   Conclusion. Determination of TL in patients with aplastic anemia is modern examination method, which is a necessary step of differential diagnosis between aplastic anemia and dyskeratosis congenita, which is the disease from group of constitutional bone marrow aplasia. It is preferred to identify the TL in adult patients with aplastic anemia by the flow-FISH. It is necessary to investigate the TL to predict treatment response and to identify risks of developing adverse experiences, which include relapse and clonal evolution.
PD-L1 and p53 expression in squamous cell carcinoma of the oropharynx depending on human papilloma virus status
Authors: Polatova D. Sh. , Madaminov A. Yu. , Savkin A. V. , Nurzhabov A. I. , Asamedinov N. K. , Ibragimova D. A. , Davletov R. R. , Nasirov S. K.
Published: September 2023

Introduction. High-risk human papilloma virus (Hpv), especially genotype 16, causes oropharyngeal squamous cell carcinoma (OSCC). It is detected in about 70 % of tumors developing from lymphoid tissue of the tonsils or the base of the tongue. Due to the increased number of Hpv-positive OSCC, Hpv status is considered a marker of OSCC clinical outcome. Easy testing, low cost, reliability, and high sensitivity of immunohistochemical analysis for p16INk4a allowed to widely use this method for Hpv status determination.

Aim. To determine the association between programmed death-ligand 1 (pD-L1) and p53 expression and presence of indirect Hpv marker – p16INk4a – in patients with OSCC.

Materials and methods. The study included 76 patients with OSCC т1–4N0–3m0 who received treatment at the Republican Specialized Scientific and practical medical Center of Oncology and Radiology (n = 37) and its Tashkent branch (n = 39) between 2015 and 2020. for all selected patients, retrospective immunohistochemical analysis for the presence of p16INk4a, pD-L1 and р53 in  tumor  samples  fixed  with  formalin  in  paraffin  blocks  was  performed.  In  our  work,  immunohistochemical  examination for p16INk4a was the only relevant tool for Hpv status determination. To reinforce its prognostic significance, we used additional molecular markers pD-L1 and p53 which play an important role in carcinogenic transformation and OSCC progression.

Results. The results of immunohistochemical analysis showed that p16INk4a overexpression was accompanied by positive pD-L1 reaction in 46 % (6/13) of cases; there were no cases of positive expression of mutant type p53. wild type p53 was identified in only 1 (3 %) case in combination with p16INk4a overexpression.

Conclusion. The developed panel consisting of 3 molecular markers (p16INk4a, pD-L1 and р53) may open new horizons in accurate prognosis, risk stratification and understanding of OSCC molecular signature. This, in turn, will help clinicians in selection of individual therapy strategies for treatment de-escalation and outcome optimization.
Impact of Connection with Nature on Users’ Satisfaction in Architecture Design Studios
Authors:   Department of Architecture, Faculty of Engineering, Salaheddin University, Erbil , Iraq, Basheer Lara , Khayat Mahmood ,   University of Kurdistan - Hewler / Architectural Engineering and Sustainability Program Director
Published: September 2023

This paper attempts to investigate the effect of visual and non-visual connection with nature of biophilic design patterns on users’ satisfaction in the architectural design studios. The study proposes how the availability of biophilic design patterns in interior spaces reflects on the user’s satisfaction level focusing on the patterns that related to connection with nature, as they spend long hours in these interior spaces according to their curriculums. The study data was collected from seven target universities from different cities in KRI, each with specific climates and design criteria. The data tool was a survey questionnaire distributed among 355 participants in separate design studios with different groups of students to achieve accuracy and reliability in the results. The results showed a direct relation between the presence of nature (visually and non-visually) and students’ satisfaction, and the following results were obtained in comparison with the study hypothesis: The one-way ANOVA statistical results showed that users were not satisfied with visual connection with nature, particularly indoor-outdoor connection, on the other hand, the satisfaction level for non-visual connection was poor as there were very limited resources to pursue this parameter. Thus, the study has concluded that the adoption of Biophilic design patterns should be taken more seriously in the future to achieve higher levels of user satisfaction. This case study allows appreciating the importance of connection with nature in affecting satisfaction level and strengthening the affiliation with nature.
DISPENSA DE MEDICAMENTOS PELO PROGRAMA FARMÁCIA BÁSICA EM GOIANÉSIA-GO
Authors: Freitas Celma Cristina , Oliveira Letícia Ferreira , Rodrigues Adelmo Martins
Published: September 2023

Objetivo: Esta pesquisa teve como objetivo analisar a dispensa de medicamentos pela Assistência farmacêutica municipal na cidade de Goianésia-GO, afim de acessar o comportamento da população em relação ao consumo de medicação, associando estes a classificação de tarjas, e também a riscos e benefícios dos medicamentos mais dispensados. Metodologia: As informações para elaboração do estudo foram obtidas através do site Sistema de Gestão em Saúde (ICS), utilizando o método observacional analítico. Assim, investigamos os medicamentos mais dispensados pela Assistência Farmacêutica (AF) no período cinco anos (01/05/2013 à 31/05/2018). Resultados: Conseguimos observar que o Omeprazol (20mg), carbamazepina (200mg), Amitriptilina (25mg), Losartana (50mg), Hidroclorotiazida (25mg), Fluoxetina (20mg), Diazepam (10mg), Ácido Acetilsalicílico (100mg), Metformina (850mg) e Fenobarbital (100mg) foram os fármacos mais dispensados neste período. Conclusão: Os medicamentos mais dispensados pela AF de Goianésia foi o Omeprazol 20mg, medicamento este de tarja vermelha sem retenção pela farmácia. Visto que, estes apresentam algumas implicações quando utilizado exacerbadamente pela população sem a devida prescrição médica. Assim sendo, ao ofertar um tratamento deve-se sempre considerar os riscos e benefícios destes fármacos para a população.
LESÃO DERMONECRÓTICA EM REGIÃO DORSAL EM UM CÃO: LESÕES COMPATÍVEIS COM LOXOSCELISMO
Authors: De Assis Santos Sílvia Vitória , De Gouveia Ribeiro Junior Carlos Roberto , Dos Santos Sandra Batista , Soares dos Santos José Rômulo , Cordão Maiza Araújo , Carneiro Arthur Nóbrega
Published: September 2023

O loxoscelismo é o quadro clínico causado pela picada de aranhas do gênero loxosceles, o qual pode apresentar-se de duas formas distintas, cutânea e cutâneo-visceral, cuja incidência varia de 84% a 97% e 3% a 16%, respectivamente. A forma cutânea é caracterizada por alterações clínicas locais, mediante o aparecimento de uma lesão inflamatória no local da picada, com presença de edema. Já a forma cutâneo-visceral é caracterizada por alterações sistêmicas, como a insuficiência renal aguda e distúrbios de coagulação sanguínea, sendo essa a forma mais letal e passível a óbito. O presente trabalho objetiva relatar um caso de tratamento de dermonecrose, após provável picada da aranha marrom e avaliar a eficiência da terapêutica adotada. O atendimento ocorreu em uma clínica veterinária localizada no município de Goiana, no estado de Pernambuco. Um cão, fêmea, da raça Poodle apresentou uma lesão eritematosa de início agudo na região dorsal com presença de edema e área necrótica associado a um abscesso fistulado, de aspecto semelhante à lesão do loxoscelismo cutâneo. O tratamento consistiu na administração de omeprazol (Gaviz-V® 10mg/Kg), cefalexina (Petsporin® 300mg/Kg) e meloxicam (Meloxinew® 0,5mg/Kg) por via oral como tratamento sistêmico e limpeza com soro fisiológico e compressas com Kollagenase® para tratamento tópico. Após 12 dias de tratamento o animal apresentava uma melhora satisfatória. O  quadro  clínico  do  presente  estudo  foi  compatível  com  acidente  por  aranhas do gênero loxosceles spp.  e o tratamento mostrou-se eficiente para a redução da lesão dermonecrótica.
Multi-Country Analysis of E-commerce Adoption: The Impact of National Culture and Economic Development
Authors:   Indiana University South Bend, Merhi Mohammad I.
Published: September 2023

Abstract Background: The effect of national culture on e-commerce adoption and usage has yet to be thoroughly examined. This multi-country study examines the influence of Hofstede’s cultural dimensions on e-commerce adoption. It also explores the moderating effect of economic development on the relationships between national culture factors and e-commerce adoption. Method: Secondary data, collected from reputable organizations on sixty countries, are used to test the hypotheses. Correlation, linear regression, cluster analysis, and ANOVA were used to assess the hypotheses presented in the model. Results: The data supported our hypotheses on the direct relationships between national culture factors namely power distance, individualism, long term orientation, and indulgence, and e-commerce adoption. The regression analysis showed that individualism is the most important of all culture factors. The results also indicated that power distance and individualism have different impact on e-commerce adoption, depending on the level of economic development. Conclusions: This study contributes to the growing empirical base of literature on e-commerce and national culture. It validated the importance of a cultural perspective in explaining e-commerce adoption at the national level. It also demonstrated the importance of economic development and its role in shaping the relationships between national culture and e-commerce.
Internet of Things Adoption for Saudi Healthcare Services
Authors:   The University of Newcastle, Jazan University, Masmali Feisal , Miah Shah J. ,   The University of Newcastle
Published: September 2023

Abstract Background: Recent studies in information systems have predicted that applications of the Internet of Things (IoT) innovations will revolutionise various sectors including healthcare. Besides the issues and opportunities of IoT based innovations, existing studies have shown limitations to advance the adoption of IoT-understanding and relevant interventions to benefit researchers and healthcare practitioners. Method: In this context, a systematic literature review study was conducted to re-position a qualitative, phenomenological investigation that could offer useful insights into the factors affecting IoT-adoption in a developing country’s healthcare service. In addition to it, five participants who worked in hospitals and clinics in Jazan, Saudi Arabia, took part in the semi-structured interviews developed based on the diffusion of innovation theory. Results: The study explored the relevant literature and evaluated how the outcome is used to identify the key delivers of IoT in healthcare. Conclusions: According to the findings, the capacity of the Saudi healthcare sector to accept and implement a new IT with IoT technologies is increasing and its integrations remains a debated issue.
Features of the use of oral anticoagulants in clinical practice: focus on gastrointestinal complications
Authors: Bakulina Natalya V. , Tikhonov Sergey V. , Apresyan Anna G. , Ilyashevich Inna G.
Published: September 2023

The review article presents dates about the physiology and pathophysiology of the hemostasis system, discusses the features of the use of oral anticoagulants in clinical practice. Oral anticoagulants are drugs characterized by predictable pharmacokinetics and pharmacodynamics, a favorable efficacy and safety profile. The article considers the main clinical and pharmacological characteristics of apixaban, rivaroxaban and dabigatran (bioavailability, metabolism, excretion); factors that increase the risk of gastrointestinal bleeding associated with anticoagulant therapy; drug interactions; the possibility of gastroprotection in patients taking oral anticoagulants. In real clinical practice, the reason for not prescribing or unreasonably reducing the dose of oral anticoagulants is the fear of bleeding. In this case, the risks of bleeding, as a rule, are overestimated. Knowledge of bleeding risk factors, prognostic scales and management of risk factors is an approach that can improve the safety of anticoagulant therapy. In clinical practice, the choice of the ideal oral anticoagulants, in addition to taking into account the risk of bleeding, should be based on a comprehensive assessment, including an assessment of the patient's age, risk of stroke and coronary events, renal function, and predicted compliance.
Development of Waterhouse–Friderichsen syndrome after infection with SARS-CoV-2 against the background of comorbidity
Authors: Alpidovskaya Оlga V.
Published: September 2023

BACKGROUND: The COVID-19 pandemic has also affected rheumatic diseases. A clinical case of the development of Waterhouse–Friderichsen syndrome after SARS-CoV-2 infection in a patient with secondary AA adrenal amyloidosis is presented.
CLINICAL CASE DESCRIPTION: Patient G., 57 years old, was hospitalized for several hours on May 20, 2023 at the Cheboksary Regional Hospital with the following diagnosis: “Severe viral interstitial pneumonia. Secondary AA adrenal amyloidosis. Acute adrenal insufficiency”. She was admitted with complaints of a febrile temperature up to 38.2°C. Computed tomography of the chest organs showed signs of bilateral viral interstitial pneumonia (the percentage of lung damage was 74%). The diagnosis of COVID-19 was based on a positive polymerase chain reaction test performed on nasopharyngeal swabs. The blood pressure was 80/40 mm Hg, D-dimer 786 ng/ml (with the normal values of not higher than 243 ng/ml). Despite the treatment, the patient died. An autopsy revealed dystelectasis, hyaline membranes, intraalveolar edema in the lungs, and the deposition of amyloid masses, foci of necrosis of the cortical layer and hemorrhage in the adrenal glands. Signs of disseminated intravascular coagulation syndrome were found.
CONCLUSION: The peculiarity of the case is the development of Waterhouse–Frideriksen syndrome without signs of sepsis.
Karakteristik mutu abon ikan sapu-sapu (Pterygoplichthys pardalis) dari Perairan Danau Tempe, Sulawesi Selatan
Authors: Kasmiati Kasmiati , Putri Andi Athifa , Sumule Ophirtus , Latuconsina Nursakinah , Khasanah Rahmatul , Khotimah Husnul , Nurfaidah Nurfaidah , Laga Suriana , Handarini Kejora , Rahmatang Rahmatang , Metusalach Metusalach
Published: September 2023

Populasi ikan sapu-sapu di Danau Tempe sangat melimpah karena jarang dimanfaatkan oleh masyarakat. Salah satu upaya untuk meningkatkan nilai ekonomis ikan sapu-sapu adalah menjadikannya produk olahan abon ikan. Penelitian ini bertujuan menentukan kualitas abon ikan sapu-sapu yang terbuat dari tiga kelompok ikan dengan ukuran yang berbeda melalui parameter sensori, komposisi kimia, logam berat, dan mikrobiologi sesuai dengan SNI-7690:2013. Sampel ikan sapu-sapu yang digunakan pada penelitian ini diambil dengan metode purpose sampling, yang dibagi ke dalam tiga kelompok ukuran, yaitu ukuran besar (>30,1 cm), sedang (20,1-30 cm), dan kecil (≤20 cm). Daging putih dari setiap kelompok ukuran digunakan sebagai sampel pembuatan abon. Analisis data menggunakan uji normalitas untuk menguji tingkat kesukaan dan dilanjutkan dengan uji Kruskal Wallis apabila data tidak terdistribusi normal. Hasil penelitian menunjukkan bahwa abon ikan sapu-sapu yang terbuat dari ukuran ikan yang berbeda mempunyai tingkat penerimaan konsumen yang baik (kategori suka) dengan nilai 3,86-4,40 dari skor maksimum 5. Uji organoleptik abon ikan sapu-sapu memenuhi persyaratan mutu organoleptik abon ikan sesuai SNI. Abon ikan sapu-sapu mempunyai karakteristik mutu, yaitu kadar air 2,52-3,11%, protein 32,34-32,40%, lemak 22,18-24,55%, dan abu 4,13-5,53%. Kadar air dan protein tersebut memenuhi standar mutu abon ikan berdasarkan SNI. Kadar logam berat (Hg, Pb, dan Cd) serta hasil uji angka lempeng total, Escherichia coli, Salmonella, dan Staphylococcus aureus berada di bawah ambang batas maksimal yang disyaratkan.
The Spectre of Woke and the Reality of Academic Freedom
Authors: van Oenen Gijs
Published: September 2023

Woke culture may clash with academic freedom. Controversial statements about e.g. sexuality or gender by academics can either be seen as protected by academic freedom, or conversely as inadmissable attack on lgbt-affiliated co-workers. Using a recent Dutch university case as a model example, this article investigates the relation between freedom of speech and academic freedom, especially as it applies to woke culture. Core issues in the culture wars around woke are identified and discussed in relation to cultural disruption represented by philosophies like that of Derrida and Foucault. It is concluded that although woke philosophy drew crucial inspiration from such philosophies, it ironically drew completely opposite conclusions regarding freedom expressed in and as language.
A case of lymphoplasmacytic lymphoma mimicking as chronic lymphocytic leukemia
Authors: Manoharan Elamathi , Ramalingam Thulasi Raman
Published: September 2023

Lymphoplasmacytic lymphoma (LPL) is a B-cell non-Hodgkins lymphoma (B-NHL) that has small lymphocytes, plasmacytoid lymphocytes and plasma cells in varying proportions. It commonly involves the bone marrow, lymph nodes, spleen and rarely other extra-medullary sites. LPL tends to have a varied morphology and immunophenotype (IPT). Though it is characterized by the presence of monoclonal IgM protein in serum, it can also be seen in other B-NHL. Thus, it may impose a diagnostic challenge by morphology and IPT in some cases. Chronic lymphocytic leukaemia (CLL) is another small B cell NHL, which has a more typical morphology and characteristic IPT. IPT is done by flow cytometry (FCM), which is a rapid and efficient tool in the diagnosis of NHL involving blood and marrow. We present a case of LPL which mimicked CLL by morphology and IPT.
El sector extractivo como palanca para la transformación productiva
Authors: Manzano Osmel , Valdivia Daniela , Balza Lenin , Díaz Lina M. , Andrian Leandro Gaston , Chávez augusto
Published: September 2023

El sector extractivo se destaca por su relevancia histórica y económica en la Región Andina. No obstante, enfrenta desafíos emergentes en virtud de los compromisos del Acuerdo de París para abordar el cambio climático y la creciente demanda de minerales críticos. Este contexto hace hincapié en la importancia de diversificar las economías, adoptar tecnologías sostenibles y considerar los efectos territoriales y medioambientales asociados con esta transición. En este documento se abordan diversos aspectos cruciales relacionados con los retos actuales del sector extractivo en la Región Andina. Se resalta la importancia de la licencia social y la confianza de la comunidad en los proyectos extractivos, así como la necesidad de mejorar la capacidad de gobernanza y promover la creación de valor compartido. La gobernanza y la transparencia también plantean retos significativos, particularmente en términos de regulación fiscal y ambiental, coordinación de políticas y promoción de la transparencia en la industria. La diversificación económica y la creación de encadenamientos productivos son elementos esenciales para un desarrollo sostenible y equilibrado en la región. La digitalización y la adopción de tecnologías digitales también desempeñan un papel fundamental para abordar los desafíos de la transición energética y cumplir con los estándares de sostenibilidad. La inclusión de grupos marginados, como mujeres y minorías étnicas, también se destaca como una necesidad crucial para lograr un desarrollo inclusivo y equitativo. A pesar de los obstáculos, la región tiene la oportunidad de transformar el sector extractivo en una palanca para la transformación productiva, aprovechando enfoques innovadores y políticas efectivas.
Impulse as a true measure of inertia
Authors: Etkin Valeriy Abramovich
Published: September 2023

Based on the system-energodynamic method of analyzing natural and technological processes, the necessity of abandoning the paradigm of homogeneity and isotropy of space filled with matter is substantiated, and a retrospective analysis of the state of mechanics is given. The principles of the determinism of the state and the opposite direction of processes in inhomogeneous (internally non-equilibrium) systems are formulated and proved. The inevitability of the emergence of an oscillatory form of energy in them and the need to consider the latter in the law of its conservation are revealed. In this way, the necessity and possibility of generalizing all three “beginnings” of Newton’s mechanics and considering irreversibility in its equations with the introduction of the “force” efficiency of mechanical processes are shown. The non-equivalence of the momentum to Descartes’ momentum is revealed, and the invariance of the mass in acceleration is proved. It is shown that the true measure of the inertial properties of a substance is the impulse, not the mass, and a generalization of the concept of inertia to non-mechanical forms of motion is proposed. The principle of interconvertibility of the oscillatory, translational, and rotational components of the impulse of internal motion in isolated systems is proved, and thus the possibility of creating a new class of propellers in outer space on this basis is substantiated.
Формирование готовности студентов к профессиональной деятельности в контексте системно-деятельностного подхода и организации работы с детьми с ограниченными возможностями здоровья
Authors: Воробьёва Н.А , Хлынина И.А
Published: September 2023

В статье рассматриваются основные вопросы формирования готовности студентов к профессиональной деятельности в контексте системно-деятельностного подхода и организации работы с детьми с ограниченными возможностями здоровья. Особое внимание уделяется вопросу учета тенденций обновления подходов к организации образовательного процесса на уровне начального общего образования в трансформации аспектов преподавания междисциплинарных курсов и организации практики по видам деятельности на этапе формирования готовности специалистов среднего звена к профессиональной деятельности по профилю специальности
Инфографика как способ формирования познавательных универсальных учебных действий на уроках по предмету «Окружающий мир»
Authors: Ворсобина Н.В , Васильченко А.В.
Published: September 2023

В статье обосновывается эффективность использования средств инфографики для формирования познавательных универсальных учебных действий на уроках по предмету «Окружающий мир». Представлены примеры разработанных упражнений. Результаты исследования свидетельствуют о положительной динамике в экспериментальной группе.
К вопросу об актуальности формирования критического мышления
Authors: Реймер М.В. , Самоходкина М.С , Тимонина И.Е
Published: September 2023

В статье рассматривается проблема формирования критического мышления. Участники системы образования подчеркивают необходимость развивать критическое мышление у школьников. Характерные навыки формируются не на одной дисциплине и, конечно, не за одно занятие. Критическое мышление требует системного подхода и особого внимания с точки зрения образовательных результатов.
Особенности организации процесса обучения иностранному языку студентов высших учебных заведений с использованием технологии BYOD
Authors: Тарзуманова И.Ф , Бельская Т.И , Киреева И.А
Published: September 2023

Актуальность исследования в статье заключается в том, что методика BYOD недостаточно изучена в России по ряду причин. Одной из них является преобладание и распространение традиционных методов обучения. Целью исследования является рассмотрение особенностей организации процесса обучения иностранному языку студентов высших учебных заведений с использованием технологии BYOD. В результате была предоставлена возможность детально ознакомиться с технологией BYOD вкупе с развёрнутым анализом достоинств и недостатков цифровой концепции в педагогической деятельности преподавателей иностранных языков высшей школы. Сделан вывод о преимуществах технологии BYOD и ее эффективности в организации процесса обучения иностранному языку студентов высших учебных заведений.
Цзинь Сян и «новая композиторская школа Китая»: основные художественноэстетические принципы
Authors: Чжэн С.Ч.
Published: September 2023

Композитор Цзинь Сян (1935–2015) является ярким представителем «новой композиторской школы Китая». Творчество Цзинь Сяна и его современников вызвало резонанс в музыкальных кругах Востока и Запада и утвердило художественно-эстетические принципы современного искусства Поднебесной. Формирование композиторов «новой волны» стало возможным благодаря росту самосознания у китайских музыкантов, стремлению к сохранению ценностей национальной культуры и их трансляции в мировое пространство. В статье раскрываются основные художественно-эстетические принципы Цзинь Сяна как представителя «новой композиторской школы Китая»
Equilibrium
Authors: Trivedi Nripesh
Published: September 2023

Fire is the only source of heat and light energy. It is often wondered what is the principle governing the movement of energy. This paper describes that. The principle governing movement of energy (or heat energy) is thermal equilibrium [1]. This is the condition governing movement of energy. Examples of thermal equilibrium could be found in atmosphere and man-made objects [1].
Turbulent Flow Analysis with Banach and Sobolev Spaces in the LES Method Incorporating the Smagorinsky Subgrid-Scale Model
Authors: Santos Rômulo Damasclin Chaves dos , Sales Jorge Henrique Oliveira
Published: September 2023

The mathematical analysis, applied in this work, serves as a pillar for a broader investigation on the regularity of the Navier-Stokes Equations. In this context, this investigation marks a significant step forward in the advancement of the Smagorinsky model coupled with the LES methodology, resulting, based on the Banach and Sobolev Spaces, a new theorem that points the way to the construction of an anisotropic viscosity model (not yet discussed in the present work). At first, the effort dedicated here aims to present a more comprehensive mathematical analysis, promoting a more leveled understanding of the challenge posed by the regularity of the Navier-Stokes equations.
Tek taraflı pseudoeksfolyasyon materyali olan glokomlu ve hastalıksız bireylerin, optik koherens tomografi-anjiografi cihazı ile makula değerlendirmesi
Authors: YÜKSEL ELGİN Cansu
Published: September 2023

Amaç: Tek taraflı pseudoekfolyasyon materyali (XFM) izlenen bireylerin; glokom geliştiği ve gelişmediği durumlarda makula vasküler yoğunluğunun gözler arası değişimini gözlemlemek.

Gereç ve yöntemler: 38 sayıda tek taraflı pseudoeksfolyasyon sendromlu (XFS) bireyin 76 gözü ve 36 sayıda tek taraflı pseudoeksfolyasyon glokomlu (XFG) hastanın 72 gözü çalışmaya dahil edilmiştir. Her iki grubun XFM olan ve olmayan gözlerinin OCT-A ile incelenen tüm makuler belirteçleri standart ortalama karşılaştırmalı t testi ile değerlendirilmiştir. Her iki gruptaki XFM pozitif ve negatif olan göz grupları birbirleriyle ve gruplar arasında Kruskal-Wallis testi ile kıyaslanmıştır.

Bulgular : Tek taraflı XFS olan hastaların gözler arası yüzeyel kapiller pleksus yoğunluğunda anlamlı farklılıklar minimal görülürken tek taraflı XFG’lerin gözler arası makulanın totalinde (p= 0,0004) üst ve alt yarımında (p=0.0018, p=0.0002), fovea (p=0,014), parafovea (p=0,0411) ,parafoveanın inferior yarımı (p=0,0126) ve temporalinde (p=0,0126); glokomlu gözlerde anlamlı düzeyde damar yoğunluğunda azalma dikkati çekmektedir. Derin kapiller pleksusta ise hem grup içi hem gruplar arası kıyaslamalarda anlamlılık, yüzeyel damar tabakasına göre azalmıştır.

Sonuç: Medikal tedaviyle kontrol edilen glokom tablolarında makula bölgesindeki özellikle yüzeyel kapiller pleksusun yoğunluğunda azalma olduğu gösterilmiştir. Ancak bu damarsal azalma glokomsuz gözlerde XFM varlığında öncü bulgu olarak gösterilememiştir.
Patho-morphological and Immunohistochemical Studies on Bovine Horn Core Carcinoma
Authors: Kumar Vivek , Jolhe Dhananjay Kumar , Ghosh Ratan Chandra , Dewangan Rukmani , Sonkusale Prashant M. , Sharma Sonu
Published: September 2023

Background: An investigation was carried out on twelve clinical cases of neoplasm of horn in Durg, Dhamtari and Rajnandgaon districts of Chhattisgarh, suspected of bovine horn core carcinoma (squamous cell carcinoma) revealed the cytology, pathomorphology and immunohistochemical (IHC) expression of Pan-cytokeratin (Pan- CK), p53 gene, epidermal growth factor receptor (EGFR) and p16 gene in tumourous growth at horn in bovines. Methods: In this field-laboratory investigation conducted during January to June 2022, we explicate the cytological, pathological and immunohistochemical alterations in bovine horn core carcinoma from 12 tissue samples. Cytological studies includes special papaniculaou staining and immunohistochemistry was performed through Benchmark automated staining system. Result: Eight out of 12 cases (66.66%) were confirmed as SCC of horn on the basis of histopathological and immunohistochemical analysis. Papanicolaou staining revealed variation in shape and size of cells and altered nuclear details. Grossly unilateral large cauliflower like neoplastic growth at the base of the horn was observed. Differentiation of tumours were based on histopathology and Immunohistochemistry. Well differentiated SCCs (n=4; 50%) were characterized by severe keratinization of horn epithelium with concentric arrangement forming keratin pearls also called as “cell nests”. Moderately differentiated SCCs (n=2; 25%) characterized by small keratin pearl formations and mitotic figures. Poorly differentiated SCCs of horn (n=2; 25%) revealed absence of distinctive keratin pearls although deep invasion from primary site was observed. Tissue samples revealed strong immunohistochemical staining of Pan-CK, p53 and EGFR and negative to p16. Highest immunohistochemical expression was observed in Pan-CK which confirmed the tumours were of epithelial origin and EGFR immunoexpression was confirmatory for malignancy and degree of metastasis.
Contribución al estudio del concepto : delincuente de cuello blanco o white collar crime
Authors: Botero Chica Carlos Alberto
Published: September 2023

El objetivo general del presente artículo es hacer una contribución al estudio del concepto: delito de cuello blanco, destacando la incorporación de una nueva terminología, que genera aportes a la teoría de la delincuencia no convencional. Es una investigación básica, que posee una metodología de tipo cualitativo, sustentada en el estudio de casos, sobre delincuentes de cuello blanco, con visión holística y transdisciplinar, que se adapta al entorno del mundo actual, apoyada en algunas disciplinas del saber que se articulan a la criminología, como rama del derecho para enriquecer su conocimiento.
Some Features of the Criminal Procedural Status of a Witness
Authors: Morozova O. S.
Published: September 2023

The relevance of the topic is due to the fact that the problems of the procedural position of a witness today need some addition and adjustment, while this particular issue requires special attention in connection with the expansion of the information space and the simplification of access to information contained in the materials of the criminal case of all participants in criminal proceedings. The question of the participation of a lawyer in criminal proceedings in order to provide qualified legal assistance to a witness remains important. In particular, the procedure for involving a lawyer in a criminal case has not been established, his procedural status has not been clearly regulated, and the issue of the possibility and limits of participation of a lawyer in investigative actions conducted with a witness has not been resolved. The purpose of the study is to analyze the legal problems related to the realization by the witness of his rights, the performance of his duties. The article deals with problematic issues related to the procedural status of a witness, analyzes the relevant norms of domestic criminal procedure legislation and the legislation of a number of foreign countries. The methodological basis of the work was the position of the general scientific dialectical method of cognition and the general theory of law, which made it possible to reveal the essence and features of the procedural status of a witness in pretrial criminal proceedings. The work widely uses the comparative legal method, which made it possible to identify the relationship between domestic and foreign legislation in the field of witness immunity. As a result, the following conclusions were made. It seems that it is necessary to provide a witness who has not formally received the status of a suspect or accused with qualified legal assistance on a mandatory basis, in order to protect his legal rights and interests. In addition, part 3 of Art. 56 of the Criminal Procedure Code of the Russian Federation, supplementing it with a ban on taking evidence from all persons who, by virtue of their official duties, are its bearers and must keep it.
Telaah Perkembangan E-Court di Indonesia (Romantisme Peradilan dan Teknologi Informasi di Era Covid-19)
Authors: Abd Muni
Published: September 2023

Badan Pusat Statistik, Potret Pendidikan Indonesia “Statistik Indonesia 2020” nomor katalog: 4301002 dalam tinjauan ekslusif Mahkamah Agung Republik Indonesia, “Cetak Biru Pembaharuan Peradilan 2010-2035” 2010. Rahardjo, Satjipto Ilmu Hukum, Citra Aditya Bakti: Cetakan Pertama, Bandung, 2012. Suadi, Amran, “Menakar Beracara di Pengadilan secara Elektornik” Kencana: Jakarta, 2012 cetakan ke 2 Undang-undang Dasar Negara Republik Indonesia Tahun 1945 Beserta Perubahannya Undang-Undang Nomor 25 tahun 2009 tentang Pelayanan Publik Undang-undang Republik Indonesia Nomor 14 Tahun 2008 tentang Keterbukaan Informasi Publik Undang-undang Nomor 48 tahun 2009 tentang Kekuasaan Kehakiman Undang-undang nomor 50 tahun 2009 tentang Peradilan Agama Undang-undang nomor 5 tahun 2014 tentang Aparatur Sipil Negara (ASN) Undang-Undang nomor 48 tahun 2009 tentang Kekuasaan Kehakiman Undang-Undang Nomor 18 Tahun 2003 tentang Advokat Peraturan Mahkamah Agung (PERMA) RI Nomor 1 Tahun 2019 tentang Administrasi Perkara dan Persidangan di Pegadilan Secara Elektronik Keputusan Mahkamah Agung RI nomor 129/KMA/SK/VIII/2019 tentang Petunjuk Teknis Administrasi Perkara dan Persidangan di Pengadilan Secara Elektronik Keputusan Mahkamah Agung RI nomor 271/KMA/SK/XII/2019 tentang Petunjuk Teknik Administrasi Perkara dan Persidangan di Pengadilan Banding, Kasasi dan Peninjauan Kembali Secara Eletronik Peraturan Mahkamah Agung (PERMA) RI nomor 2 tahun 2009 Biaya Proses Penyelesaian Perkara Peraturan Pemerintah nomor 5 tahun 2019 tentang jenis dan tarif Penerimaan Negara Bukan Pajak https://www.bps.go.id xi POTRET PENDIDIKAN INDONESIA Statistik Pendidikan 2020, diakses tanggal 1 Maret 2020 jam 16.03 WIB.
Konsep Independent Regulatory Agencies Dalam Kewenangan DKPP Sebagai Lembaga Peradilan Etik
Authors: Muchlisin
Published: September 2023

The research in this journal discusses the authority of the Election Organizing Honorary Council (DKPP). DKPP is one of the triumvirate election organizers in Indonesia whose authority is to handle problems that occur between Election Organizing Institutions. This research uses normative law research methods by using several approaches including statute approach, case approach, and conceptual approach. In the Political Law of Elections in Indonesia, the status a quo gives the DKPP such coercive authority related to the enforcement of the code of ethics. However, over time, there is a problem that considers that DKPP has exceeded the limits of its authority as an Ethics Institute. Moreover, after the transfer of his secretariat to the Ministry of Home Affairs, it was feared that it would interfere with the independence of the DKPP as one element of the election organizers. Because basically the EMB must be independent and with integrity. The transfer is based on Presidential Decree No. 67 of 2018. This should not have happened because the Elections Organizing Body does not only handle the legislative election process but also the Executive. So it is feared when this happens it will interfere with the independence of the DKPP. Bearing in mind that, the decision of the DKPP is final and binding.
Lembaga Peradilan Khusus Pemilu Di Indonesia dalam Perspektif Hukum Tata Negara
Authors: Muni Abd Muni
Published: September 2023

Negara Indonesia menganut sistem demokrasi dengan mengedepankan suara rakyat, tak pernah lepas dari suksesi kepemimpinan melalui pemilu. Pesta demokrasi di Indonesia dinaungi oleh sebuah lembaga yang bernama BAWASLU (Badan Pengawasan Pemilu). Salah satu kewenangan BAWASLU adalah mengawasi dan menyelesaikan pelanggaran dan sengketa Pemilu. Namun dalam hal ini dapat dimengerti ada dua kewenangan yang dimiliki oleh BAWASLU yakni  mengawasi dan juga menyelesaikan sengketa pemilu.

Tulisan ini akan membahas tentang dua kewenangan yang dimiliki bawaslu tersebut apakah sudah memenuhi asas-asas penyelenggara pemilu, salah satunya jika dikaitkan dengan asas profesionalitas dan akuntabilitas. Selanjutnya ditinjau dari perspektif ius constituendum ada dua istilah yang harus dipahami lebih lanjut yakni electoral board  dan electoral court. KPU dan Bawaslu sendiri pada dasarnya termasuk kedalam electoral board,  sementara yang harus dipertegas disini adalah lembaga yang dikhususkan untuk menyelesaikan pelanggaran dan sengketa pemilu secara akuntabel dan profesional. Electoral Court adalah lembaga baru yang dibuat berjenjang mengikuti jenjang struktur KPU dan Bawaslu. Lembaga Peradilan Khusus Pemilu bertujuan untuk menangani pelanggaran dan sengketa kepemiluan diluar struktur Kekuasaan Kehakiman konvensional.