bluuebunny/crossref_metadata_2025 huggingface dataset:
Algumas notas sobre Filosofia da Matemática e Filosofia da Educação Matemática
Authors: Garnica Antonio Vicente Marafioti
Published: November 2022

A partir da perspectiva de que o campo da Educação Matemática tem se ampliado consideravelmente, de modo a incorporar novos objetos, metodologias e abordagens, este artigo questiona o papel que as Filosofias “clássicas” da Matemática têm desempenhado no desenho desse campo, principalmente no que diz respeito à constituição de uma Filosofia da Educação Matemática cujo papel deve ser promover a incorporação de práticas, procedimentos e valores que respondam mais efetivamente às demandas do tempo presente e às necessidades da prática pedagógica cotidiana.
Peran Ma’had Darul Qur’an Wal Adist Nw Pancor Dalam Membentuk Relasi Sosial Yang Berkarakter
Authors: Jiddan Masrur , Tarmizi Muh.
Published: November 2022

Pesantren merupakan lembaga pendidikan tertua di Indonesia, yang secara nyata telah melahirkan banyak ulama sebagai transmisi dan transfer ilmu-ilmu keislaman, menjaga tradisi, dan refroduksi ulama. Selain itu juga, Peran Pesantren tumbuh dalam Masyarakat untuk melayani berbagai kebutuhan Masyarakat. Pesantren pun tumbuh munjadi lemabaga keagamaan yang melakukan kontrol sosial dan juga rekayasa sosial. Bahkan, di saat pendidikan moderen, sekolah dan madrasah, belum menjamah pelosok pedalaman/pedesaan, pesantren mampu menjadi lembaga pendidikan masyarakat.

 Pesantren juga berperan sebagai tempat mempelajari ilmu pengetahuan khususnya ilmu agama yang dimana untuk mempelajari, memahami, mendalami, menghayati, dan mengajarkan agama islam dengan menekankan pentingnya moral sebagai identitas lembaga pendidikan  islam dan merupakan duplikasi dari masyarakat
Effects of Negarim Micro Catchment on Growth and Survival of Two Provenances of Moringa oleifera Under Different Spacing in a Semi-Arid Area of Kitui County, Kenya
Authors: Obala Desmond , Muriu-Ng’ang’a Felista , Kiruki Harun , Mutiso Festus , Ndung’u Charles
Published: November 2022

Kenya has a large population of multifunctional tree species like Moringa oleifera (Lamark). Two provenances of Moringa oleifera from areas of Gede and Machakos were used in a study to examine how Negarim micro catchment affects their growth and survival traits under various spacings. An experiment was set up in a Randomised Complete Block Design with three replicates. Root collar diameter, branches development, survival rate and increase in height were the variables of interest and data was collected for 16 months (January 2018/April 2019). For Gede provenance under catchment, plant height ranged from 83 to 123 cm, root collar diameter from 1.7 to 2.5 cm, number of branches from 13 to 15, and survival rate of 51 to 74 %. Under no catchment, plant height varied from 127 and 191 cm, root collar diameter between 2.7 and 4.4 cm, number of branches between 15 and 19, and survival rate between 70 and 75 %. The Machakos provenance results under catchment revealed that plant height varied from 62 to 174 cm, root collar diameter ranged from 0.9 to 4.7 cm, the number of branches varied from 8 to 15, and survival rate ranged from 48 to 69 %. Under no catchment, it reached a height of between 43 and 171 cm, root collar diameter between 1.5 and 3.6 cm, 10 to 16 branches, and survivability of between 57 and 78 %. Provenance and Negarim micro catchment had a significant effect on survivability (p ≤ 0.05), height (p ≤ 0.05), and branch development (p ≤ 0.05). The significant differences between plants under Negarim micro catchment were because the catchment provided more moisture advantages to plants than those that were under no catchment. This demonstrates their appropriateness and the possibility of recommending them to be included in tree cultivation systems in the area and other places with comparable climatic circumstances. This research is noteworthy in promoting soil erosion management and environmental preservation by providing information and methods for effectively using runoff in valuable crops/tree production
Antibacterial activity of medicinal plants against Leptospira spp.: a literature review
Authors:   Universidade Paranaense, Melo Ailton da Cruz
Published: November 2022

Leptospirosis is a zoonosis caused by bacteria of the genus Leptospira that affects animals and humans. This disease is usually treated empirically due to its prevalence in precarious areas without basic sanitation. The use of medicinal plants in less industrialized societies has been one of the main therapeutic resources available. Considering the need touse these natural resources to combat leptospirosis in areas of socioeconomic vulnerability, this study aimed to review the literature on the useof plants with medicinal potential in thetreatment of leptospirosis. The results showed that even though leptospirosis is a common disease in communities lacking basic sanitation and economic development, the number of studies on the use of plants with medicinal potential is scarce. Most of these studies comefrom India, and all plants investigated between 2012 and 2020 had antileptospiral action.
pomoea batatas(L.) Lam. (Convolvulaceae) as a source of polyphenols with antitumor activity and prospects for in vitro production using chemical elicitors -A Review
Authors:   University of La Guajira, Salgado Chavez Jose Alberto , Ramirez Aristizabal Luz Stella ,   Technological University of Pereira, Mosquera Martinez Oscar Marino ,   Technological University of Pereira
Published: November 2022

Ipomoea batatas has an enormous projection as functional food and it is an excellent source of anticancerous or chemopreventive substances. Plant tissue culture offers the possibility of inducing secondary metabolites production under controlled conditions and their projection for industrial purposes. To establish the state of knowledge regarding advances in polyphenols chemical elicitation from I. batatas and the possibility of producing potential anticancerous compounds in vitro culture systems, a bibliometric review and an analysis of information available until 2020 were made. Results showed that research field on which review was carried out is current and has a growing trend; however, sweet potato cell suspensions evaluation is scarce. Elicitation using compounds with hormonal effects represents a good alternative to increase phenolic acids production in this species. Advances in phenols elicitation from sweet potato cell suspensions will require search superior genotypes, and associating this knowledge with in vivo and in silico studies.
Taking the path of least resistance now, but not later: Pushing cognitive effort into the future reduces effort discounting
Authors: Johnson S. Tobias , Most Steven B.
Published: November 2022

Effort discounting describes the devaluation of rewards that require effort to obtain. The present study investigated whether discounting of cognitive effort depends on how near the effort is in time. The present study also investigated whether effort discounting, and its modulation by temporal distance to the effort, might depend on need for cognition, a personality trait that describes how much one enjoys cognitively demanding tasks. Participants performed a validated effort discounting task that measured the extent to which they subjectively devalued a $20 reward when effort was required to receive it. Immediacy of the effort was manipulated by having participants imagine exerting varying levels of effort either immediately, in a day, or in a month. Results revealed linear increases in discounting of rewards as a function of both how much effort was involved and how imminent the effort was. The extent to which both these variables influenced discounting correlated with need for cognition. Individuals low in need for cognition exhibited more effort discounting overall and a linear increase in effort discounting as the effort grew imminent. Individuals high in need for cognition engaged in less effort discounting, which was not modulated by how imminent the effort was. These results indicate that people exhibit dynamic inconsistency in effort-related decisions, such that the degree to which they discount effort depends on how soon the effort is. Additionally, this tendency is linked with systematic individual differences in need for cognition. Lastly, this study demonstrates that these tendencies can be quantitatively operationalized.
Gestión del conocimiento y habilidades gerenciales en el rendimiento laboral del personal de una institución educativa. Ventanilla, 2021
Authors: Vilca Chaicha Sonia Luz
Published: November 2022

La presente investigación tiene como objetivo general explicar la gestión del conocimiento y habilidades gerenciales influyen en el rendimiento laboral del personal de una institución educativa. Ventanilla, 2021. El estudio se desarrolló en el enfoque cuantitativo de diseño no experimental, transversal y correlacional causal. La muestra estuvo conformada por 105 trabajadores N° 5130 Pachacutec, siendo su elección de modo no probabilístico, los instrumentos pasaron por pruebas de validez y confiabilidad para ambas variables. En los principales se observa que el 8.6% del personal encuestado perciben que la gestión del conocimiento es de nivel deficiente, mientras que el 57.1% señala que este es moderado. Sin embargo, el 34.3% manifiesta que el nivel de la gestión del conocimiento es eficiente, según la percepción del personal de una institución educativa del distrito de Ventanilla en el año 2021. Se concluyó que el análisis estadístico ha permitido corroborar que la gestión del conocimiento y habilidades gerenciales influye de manera significativa de modo probabilístico con un 58.1% en el rendimiento laboral de una institución educativa del distrito de Ventanilla año 2021; con lo cual la relación causal de la hipótesis general queda demostrada (gl: 2 y p: 0,000).
SCIENTOMETRIC ASSESSMENT OF RHEUMATOID ARTHRITIS (RA) RESEARCH PERFORMANCE IN INDIA DURING 2002-2021
Authors: Amin Jignesh , v Yogesh , Patel Pradip
Published: November 2022

The current study focused to identify the Indian research contribution on Rheumatoid arthritis (RA). Rheumatoid arthritis (RA) is a systemic autoimmune disease, in which human immune system has attacks on their own healthy cells, characterized as compulsive and progressive with severe inflammatory attacks. The current study exclusively examines 2007 published articles only which have been indexed in the Web of Science (WoS) Core Collection database published and indexed in between 2002 to April 2021. Scientometric analysis use as the research tool and method to fulfil the objective of study. Furthermore, statistical correlations using RStudio and Python have been used where its required to understand, demonstrate and visualization. The analysis figured out a total of 2007 articles published during the period, of which 10993 authors appeared with rate of 3.43% authors per document. Chronological Analysis indicates the steady growth with 6.61 publications per year where 2018 accounted as the most productive year with 197 (9.82%) publication. Mean RGR (P) for first 10 years is 0.34 downfalls in last 10 years to 0.15. The rate of Doubling time for first decade of study accounted 2.00 increased to 7.50. As a result, there is an enormous growth of scholarly literature on the subject. It will be very useful for the Indian researchers and scientist for understanding the growth of publications output in the Rheumatoid arthritis (RA) or Gatiya and identifying research collaborator.
Pandemide Artan Akut Ekstremite İskemisinin Farkında mıyız?
Authors: ŞAHİN Serpil
Published: November 2022

Derginizde yayınlanan Göçgün ve İkizceli’nin 2021 yılında derginizde yayınlanan ‘COVID-19 ile İlişkili İskemik İnmenin Görüntüleme Bulguları’ isimli makalesini ilgiyle okudum. Yazarlar bu makalede, COVID-19’un iskemik komplikasyonu olan akut iskemik serebrovasküler olaya değinmiştir. Bu yazıda ise, bir diğer iskemik komplikasyon olan akut ekstremite iskemisi (AEİ) konusunda değinilmek istendi.
Searching for the Signal of a Primordial Black Hole from CMB Lensing and γ-Ray Emissions
Authors: Tan Xiu-Hui , Yan Yang-Jie , Qiu Taotao , Xia Jun-Qing
Published: November 2022

In this letter, we search for the signal of primordial black holes (PBHs) by correlating the γ-ray emissions in the MeV energy band produced by the Hawking evaporation and the lensing effect of the cosmic microwave background (CMB). We use the conservative case of the astrophysical model as much as possible in the calculations, since the potential astrophysical origins dominate the observed emission in the MeV energy band. By carefully discussing the appropriate energy bands corresponding to different PBH masses, it is worth expecting a tight constraint on the fraction of the Schwarzschild PBHs in the mass range of 1016–5 × 1017 g by simulations of the sensitivity of the future CMB-S4 project and the γ-ray telescope e-ASTROGAM. Furthermore, we also consider the PBH model with spins and find that the constraining ability of the PBH fraction from the correlation between CMB lensing and γ-ray emissions can be improved by another order of magnitude, which could importantly fill the gaps with PBH fraction limits in the mass range of 5 × 1017–2 × 1018 g.
Effects of Impact and Target Parameters on the Results of a Kinetic Impactor: Predictions for the Double Asteroid Redirection Test (DART) Mission
Authors: Stickle Angela M. , DeCoster Mallory E. , Burger Christoph , Caldwell Wendy K. , Graninger Dawn , Kumamoto Kathryn M. , Luther Robert , Ormö Jens , Raducan Sabina , Rainey Emma , Schäfer Christoph M. , Walker James D. , Zhang Yun , Michel Patrick , Michael Owen J. , Barnouin Olivier , Cheng Andy F. , Chocron Sidney , Collins Gareth S. , Davison Thomas M. , Dotto Elisabetta , Ferrari Fabio , Isabel Herreros M. , Ivanovski Stavro L. , Jutzi Martin , Lucchetti Alice , Martellato Elena , Pajola Maurizio , Plesko Cathy S. , Bruck Syal Megan , Schwartz Stephen R. , Sunshine Jessica M. , Wünnemann Kai
Published: November 2022

The Double Asteroid Redirection Test (DART) spacecraft will impact into the asteroid Dimorphos on 2022 September 26 as a test of the kinetic impactor technique for planetary defense. The efficiency of the deflection following a kinetic impactor can be represented using the momentum enhancement factor, β, which is dependent on factors such as impact geometry and the specific target material properties. Currently, very little is known about Dimorphos and its material properties, which introduces uncertainty in the results of the deflection efficiency observables, including crater formation, ejecta distribution, and β. The DART Impact Modeling Working Group (IWG) is responsible for using impact simulations to better understand the results of the DART impact. Pre-impact simulation studies also provide considerable insight into how different properties and impact scenarios affect momentum enhancement following a kinetic impact. This insight provides a basis for predicting the effects of the DART impact and the first understanding of how to interpret results following the encounter. Following the DART impact, the knowledge gained from these studies will inform the initial simulations that will recreate the impact conditions, including providing estimates for potential material properties of Dimorphos and β resulting from DART’s impact. This paper summarizes, at a high level, what has been learned from the IWG simulations and experiments in preparation for the DART impact. While unknown, estimates for reasonable potential material properties of Dimorphos provide predictions for β of 1–5, depending on end-member cases in the strength regime.
Molecular typing of dengue virus in Mizoram, Northeast India
Authors: Sailo Christine Vanlalbiakdiki , Ghatak Souvik , Sarathbabu Subbarayan , Bariha Girija Shankar , Majumder Ayan , Singh Abhinav , Lalremruata Ralte , Zomawia Eric , Lalrinpuia Benjamin , Lalfak zuali  , Zothanzama John , Senthil Kumar Nachimuthu
Published: November 2022

Introduction: Dengue is an emerging vector-borne public health threat and characterization at the molecular level is important for proper management of the disease. The aim of the study is to examine the diversity of the dengue viral serotypes from a hilly mountainous region of Northeast India.

Methodology: Thirty-six blood samples that were positive for dengue virus IgM antibodies identified by the enzyme-linked immunosorbent assay (ELISA) method were collected and quantified for the IL6 gene expression by using reverse transcriptase polymerase chain reaction (RT-PCR).

Results: All the patients had dengue hemorrhagic fever (DHF); 12 samples had a monotypic infection and 14 samples had dual infection with various dengue virus (DENV) serotypes; one sample had triple infection with DENV-1, DENV-2, and DENV-3.

Conclusions: This study identified DENV-1 as the major serotype in the state of Mizoram and it is the first report on the molecular typing of the dengue virus from the hilly mountainous state located in the Indo-Burma region bordering Myanmar and Bangladesh.
Acute hepatitis in a paediatric patient: immune-mediated drug-induced liver injury or albendazole-induced autoimmune hepatitis?
Authors: Dragutinović Nataša , Barać Aleksandra , Stevanović Goran , Đorđić Irena , Paglietti Bianca , Micić Jelena , Aleksić Ema , Martinov Nestorov Jelena
Published: November 2022

Introduction: Drug-induced liver injury (DILI) is one of the most common causes of liver damage. A large number of drugs, dietary supplements, and herbal medications can cause hepatotoxicity. In some situations, it is difficult to distinguish between DILI and autoimmune hepatitis, especially when the mechanism is immune-mediated. Albendazole is a drug that has been used for decades for the treatment of parasitic infections in humans. One of the side effects is liver enzyme elevation, but rarely requires the discontinuation of therapy. Previous experience has shown that hypersensitivity is the most common mechanism of albendazole hepatotoxicity.

Case report: Here we presented a paediatric patient in whom albendazole induced severe liver injury. In laboratory analyses, in addition to markedly elevated transaminases and parameters of cholestasis, there was also a significant increase in IgG, so autoimmune hepatitis was considered. Even though the liver histology indicated toxic liver disease, prednisolone was started. Corticosteroid therapy resulted in the complete normalization of liver function, as well as IgG. With the cessation of corticosteroid therapy, transaminases, bilirubin and gamma-glutamyl transferase (GGT) remained within normal levels, but an increase in anti-smooth muscle antibodies (SMA) was noted in immunological analyses after one year of follow-up.

Conclusions: Immune-mediated hepatotoxicity from albendazole is one possible mechanism of liver injury. The use of albendazole in the treatment of parasitic infections, especially in children, requires close monitoring. The question remains as to whether albendazole is a drug that can induce autoimmune hepatitis in the paediatric population.
Impact of prolonged wearing of face masks – medical and forensic implications
Authors: Guleria Ankita , Krishan Kewal , Sharma Vishal , Kanchan Tanuj
Published: November 2022

Since December 2019, the global outbreak of coronavirus disease had a significant impact on humanity. Because of the large number of casualties worldwide, the WHO (World Health Organization) declared the coronavirus disease caused by SARS-CoV-2 a pandemic. Since the start of the pandemic, facial masks have become essential as well as mandatory to protect ourselves from COVID-19. As a result of the pandemic, healthcare professionals (HCPs) have been required to wear personal protective equipment (PPE) for extended periods. Wearing face masks for an extended period has been shown to have several negative effects on HCPs. Additionally, face masks have hampered the use of digital techniques for facial identification. This paper examines the effects of wearing face masks for an extended period, as well as the effect of wearing face masks on facial identification technology. The Web of Science, PubMed, and Scopus databases were searched and screened for relevant studies. According to the current review, prolonged use of masks was found to be associated with adverse effects on the face and skin, including acne, redness, rashes, and itching. The use of masks also resulted in headaches, hypoxic conditions, and changes in voice and speech parameters. This communication in no way intends to advocate the discontinuation of wearing masks, on the contrary, the primary goal of this article is to spread awareness about the adverse effects associated with prolonged use of facial masks (N95, KF94, or surgical). This will help in increasing compliance with mask mandates by helping to develop preventive solutions to the problems that tend to deter the general public. This also demonstrates how the use of masks has become a challenge for facial recognition technologies.
Global Health priorities: repositioning routine immunization for infants
Authors: Bellizzi Saverio , Pichierri Giuseppe , Kheirallah Khalid , Panu Napodano Catello M
Published: November 2022

The first year of the Coronavirus disease (COVID-19) pandemic registered the highest number of children under the age of one year who did not receive basic vaccines since 2009. The pronounced rise in vaccine-preventable diseases in 2020 and 2021 was largely attributable to the disruption of the vaccine schedule for children around the world. Routine vaccinations were missed in consideration of movement restrictions to prevent the spread of COVID-19. On the other hand, health resources were re-allocated to COVID-19, resulting in strained health care systems and the marginalization of essential health services like routine vaccination campaigns. The COVID-19 pandemic has clearly illustrated the potential of vaccines in saving lives and preventing disabilities. The unequal roll-out of vaccination programmes has simultaneously deepened the existing gaps between high and low-income countries. Disruption in other key life-saving immunization programmes is driving these inequalities even further. Prompt and sustainable investments in routine immunization programmes, including catch-up vaccination strategies, are essential to avert the impact of years of neglect of this important public health issue. In particular, the recent declining trends in vaccination coverage are putting decades of progress at risk.
A Systematic Review of Tropical Disease Prevalence among Migrants
Authors: Arifin Mohd Afiq , Su Peng Chua , Baharudin Ummi Mirza , Baharudin Mohd Hafiz , Rahim Muhammad Aklil Abd , Rahim Syed Sharizman Syed Abdul , Atil Azman , Madrim Mohd Faizal , Ahmad Zulkhairul Naim Bin Sidek , Mokti Khalid , Ramdzan Abdul Rahman , Jeffree Mohammad Saffree , Hassan Mohd Rohaizat
Published: November 2022

BACKGROUND: Few studies have assessed the burden of tropical diseases among migrants into non-endemic countries.

AIM: This study aimed to systematically review the existing data of the prevalence of tropical diseases globally, including neglected tropical diseases globally.

MATERIALS AND METHODS: The authors conducted a systematic review reporting prevalence (including seroprevalence) of tropical diseases following the PRISMA guidelines and based on the database from PUBMED, WoS, and PROQUEST. All the identified records were screened according to the inclusion and exclusion criteria. The selected articles’ quality was appraised using the mixed methods appraisal tool to ensure its quality.

RESULTS: Overall, 19 studies conducted in 13 countries published between the year 2017–2020 were included in the study. Based on the thematic analysis, two themes (type of organism) and 11 sub-themes (disease) were used. The prevalence of tropical diseases among migrants ranged from 0.2 to 31% for malaria; 3–20% for Chagas Disease; 3.2–3.5% for Giardiasis; 31.7–57.4% for Toxoplasmosis; 0.1–51%, for Schistosomiasis; 0.1–15.8%, for Strongyloidiasis; 0.3–3.8% for Trichuriasis; 0.2–0.9% for Ascariasis; 6.4–9.7% for Toxocariasis; 0.3% for Loiasis; and 0.5% for Filariasis. All migrants warrant thorough screening and testing, based on the country of origin of their last visit. Routine screening and follow-up may reduce the re-emergence of tropical disease in non-endemic countries.

CONCLUSION: Multiple approaches in managing social and health issues among migrants are vital to secure healthy labor forces for the country’s economy and development. Public health sectors should implement strategic promotive, preventive, and curative programs targeted to this group.
Maternal Health Through the Use of Herbal Medicines and Traditional Medicinal Plants for Public Health and Ancestral Culture
Authors: Harahap Junardi
Published: November 2022

BACKGROUND: The use of traditional medicine for maternal health is very important, to overcome various health problems experienced by mothers, using medicinal plants in the community. Especially with the past modern medicine, the modern one is expensive in medicine compared to the traditional medicine which is much cheaper.

METHODS: The criteria used in this study were the existing mothers, carried out by conducting qualitative research, and also conducting a survey that conveyed how the respondents responded to medicinal plants.

RESULTS: The purpose of this study was to identify medicinal plants used by mothers for their medicinal plants and recommendations for the use of good medicinal plants among mothers to overcome health problems experienced by mothers.

CONCLUSION: Various types of medicinal plants are used by mothers for health and benefits for mothers. Medicinal plants used by mothers are still limited from the information obtained by mothers on the internet, and also for hereditary factors that are culturally lacking, the rest are from neighbors. Recommendations are given to carry out the necessary studies given further studies related to medicinal plants and the preservation of existing traditional cultures.
Citizen Compliance to Prevents COVID 19 after Vaccination
Authors: Setyorini Yuyun , Darmawan Rendi Editya , Setiawan Setiawan
Published: November 2022

BACKGROUND: The Coronavirus Disease 2019 (COVID-19) has been happening for the past 2 years and makes people bored to follow health protocol. On the other hand, the most effective way to prevent COVID is the health protocol. Vaccines catch people off guard, and there is potential for ignoring health protocols.

AIM: The aim of this study is to describe citizen compliance to prevent COVID-19. Consist of wearing a mask, keep distance, and washing hands.

METHODS: A descriptive studies with 76 respondents that choosing by simple random sampling. Data obtained by means of direct interviews with respondents. Instrument asks to respondent recorded by Google form. Data were analyzed using frequency and percentage.

RESULTS: the most participant agree and strongly agree to prevent COVID-19 consists of wearing a mask, keep distance, and washing hands. Only 1 person declare that not agree with her habits to keep distance to other people.

CONCLUSION: Indonesian people have good habits in preventing COVID-19, even though the COVID transmission rate is increasing.
Neurological Manifestations of Fabry Disease: Literature Review
Authors: Grigolashvili Marina , Kim Ekaterina , Muratbekova Shynar , Omarova Sholpan , Smagulov Amirzhan , Bektas Guldana , Tuleuov Rustam , Madibraimova Saltanat , Pakhomov Artyom , Parkhanovich Olga , Pogorelova Ekaterina , Kiyakpaeva Gulsara
Published: November 2022

BACKGROUND: Fabry disease (FD) or Anderson FD is a hereditary disease belonging to the group of lysosomal storage diseases caused by decreased or absent activity of the enzyme α-galactosidase A. Enzyme deficiency leads to accumulation of glycospholipids in the lysosomes of cells of various organs, including the heart, kidneys, nervous system, and vascular endothelium. The complexity of the diagnosis of FD is due to the variety of its symptoms, the simultaneous involvement of many organs and systems. At present, possible pathogenetic treatment of the disease is enzyme replacement therapy, but its effectiveness is reduced in the later stages of the disease, when there are irreversible abnormal changes in vital organs and systems. In this regard, an urgent task is the early diagnosis of FD.

AIM: Determination of neurological manifestations of FD as well as clinical criteria for screening for FD.

MATERIALS AND METHODS: We analyzed cohort studies, randomized controlled trials, systematic reviews and meta-analyses, case-control studies, and case series from scientific medical databases: PubMed, Web of Science, Google Scholar in Russian, and English languages.

CONCLUSION: The authors found that lesions of the nervous system in FD are detected in more than 80% of patients and can manifest as isolated or combined lesions of both the central and peripheral and autonomic nervous systems.
Pricing and Phasing of In Vitro Fertilization Services in Republic of Macedonia
Authors: Seistrajkova Marija , Dimitrov Gligor , Petanovski Zoran , Iljovska Srebra
Published: November 2022

Introduction: In vitro fertilization (IVF) services in North Macedonia are mainly provided in private hospitals. The expenses for this service are covered by the HIF, by issuance of a voucher to the patients. One voucher is for one IVF cycle. Price of the voucher was determined in 2012 and specified protocols for provision of the service were set. Since then, the price was not revised or adjusted. Objective of this research is to adjust the price for IVF services in the country, based on existing national protocols and in accordance to the realistic costs.
Materials and Methods: Data from RE-MEDIKA’s electronic system for patients’ medical information (BIRPIS) was extracted. Information was related to patients who undergo the procedure covered by the Health Insurance Fund (HIF) - voucher. For defining direct costs, internal data from the hospital was used and adjusted. For defining indirect costs, data for overhead expenditures of the hospital was adjusted. Description of costs was made in accordance with the national protocol for IVF. Tables (excel spread sheets) used for the calculation are developed by the HIF.  
Results: The process of IVF was divided in three consecutive phases: phase 1- induction, phase 2 - fertilization and phase 3 - embryo transfer (ET). Each phase was priced accordingly. If all three phases are finished and ET is performed, the final full price for one IVF cycle - voucher is about 104,000 Macedonian denars (about 1,700 Euros).
Conclusion: We suggest introducing of phasing for the IVF process related to payment per phases’ finalization, where the next phase follows consequently. This phasing enables the patients to understand the procedures and the progress of the process; enables doctors to follow up the finalization and successfulness of the procedure; and gives the payer (buyer of the service, HIF) complete overview of the procedure and payment for each phase separately. Thus, success or failure of the entire process in specific phases can be monitored and evaluated.
Dietary Risk Assessment of Acrylamide in School Canteen Snacks among Primary School Students in Alexandria Governorate
Authors: El-Tawila Mahmoud , Agamy Neveen , Emara Rana , Aboorhyem Samar , Elzayat Amira
Published: November 2022

Abstract BACKGROUND: Acrylamide (AA) is considered as a carcinogenic and genotoxic food contaminant produced in carbohydrate-rich foods Canteen snacks available in school are among these carbohydrate-rich foods. The paper investigates the risk associated with consuming acrylamide rich canteen snacks.   AIM:  The aim of the work was to study the dietary risk of acrylamide in school canteen snacks among primary school students and to determine the concentration of AA in different snacks   METHODS: The level of AA was detected in 73 samples for 16 different canteen snacks sold at school canteens. Samples were collected randomly from the canteens of primary schools in Alexandria city. All samples were extracted and cleaned-up then analyzed using HPLC techniques. A food frequency questionnaire was designed to determine the frequency and amount of consumption of different canteen snacks among primary school students during school day. The data was collected from six different primary schools in Alexandria city (3 public and 3 private schools). All interviewed school students (466 student) were weighted for the calculation of dietary exposure of AA during school day.   RESULTS: The results showed that, the average and the 95th percentile of acrylamide exposure were 1.4 and 4 μgkg−1 BWsd−1, respectively. There is a statistically significant difference between dietary exposure to AA between private schools and public schools. The estimated margin of exposure (MOE) calculated from the average acrylamide exposure was 128 and 221 and from 95th percentile was 45 and 77, based on BDML10 values 0.18 mgkg−1 BWd−1 and 0.31 mgkg−1 BWd−1. With the highest risk calculated in schools offering fried foods prepared in school canteen.   CONCLUSION: Dietary exposure to AA from canteen snacks among primary school students in Alexandria city is considered as a health concern according to the definition of the WHO, where the calculated MOE values were very close to the values set by the JECFA committee (45-310) for health problems of concern.
Présentation
Authors: Blanchet Vincent
Published: November 2022

Intitulé « Le dieu inconnu », l’article de Reiner Schürmann ici publié et traduit en français parut d’abord en allemand au mois de mai 1966 dans la revue Der christliche Sonntag . Sa tâche est simple et radicale, puisqu’il s’agit de traverser les façons dont nous parlons de Dieu afin d’éprouver si sa divinité y est encore pour nous accessible. Schürmann est alors jeune dominicain de la province de France, il se destine à la prêtrise et s’apprête à commencer une thèse de lectorat sur Maître Eckhart. En mars de la même année, soit quelques mois avant la publication de ces pages, Schürmann avait rencontré Heidegger dans l’espoir de lui faire parler de Dieu. Telles sont les trois puissances qui règnent sur cet article : la jeunesse, le christianisme et la philosophie. Plus précisément : l’allemand maternel, Maître Eckhart et Heidegger.
Computational approach using machine learning modelling for optimization of transesterification process for linseed biodiesel production
Authors: Gautam Sunil , Kanakraj Sangeeta , Henry Azriel
Published: November 2022

In this research work, various machine learning models such as linear regression (LR), KNN and MLP were created to predict the optimized synthesis of biodiesel from pre-treated and non-treated Linseed oil in base transesterification reaction mode. Three input parameters were included for modelling, reaction time, catalyst concentrated ion, and methanol/oil-molar ratio. In biodiesel transesterification reaction 180 samples run with non-Pre-treated Linseed Methyl Ester (NPLME), Water Pre-treated Linseed Methyl Ester (WPLME) and Enzymatic Pre-treated Linseed Methyl Ester (EPLME) oil as feed stocks and optimized parameters are find out for maximum biodiesel yield to be 8:1 molar ratio, 0.4% weight catalyst, 60 °C reaction temperature.To test the technique, R2 and MAPE parameters were used. The average R2 values for linear regression, KNN, and MLP are 0.7030, 0.8554 and 0.7864 respectively. Moreover, the average MAPE values for these models are 11.1886, 6.0873 and 8.0669 respectively. Hence, it is observed that the KNN model outperforms other models with higher accuracy and low MAPE score.
A new three-term conjugate gradient algorithm with modified gradient-differences for solving unconstrained optimization problems
Authors: Guo Jie , Wan Zhong
Published: November 2022

Unconstrained optimization problems often arise from mining of big data and scientific computing. On the basis of a modified gradient-difference, this article aims to present a new three-term conjugate gradient algorithm to efficiently solve unconstrained optimization problems. Compared with the existing nonlinear conjugate gradient algorithms, the search directions in this algorithm are always sufficiently descent independent of any line search, as well as having conjugacy property. Using the standard Wolfe line search, global and local convergence of the proposed algorithm is proved under mild assumptions. Implementing the developed algorithm to solve 750 benchmark test problems available in the literature, it is shown that the numerical performance of this algorithm is remarkable, especially in comparison with that of the other similar efficient algorithms.
Extensions of mean-field approximations for environmentally-transmitted pathogen networks
Authors: Davies Kale , Lenhart Suzanne , Day Judy , Lloyd Alun L. , Lanzas Cristina
Published: November 2022

Many pathogens spread via environmental transmission, without requiring host-to-host direct contact. While models for environmental transmission exist, many are simply constructed intuitively with structures analogous to standard models for direct transmission. As model insights are generally sensitive to the underlying model assumptions, it is important that we are able understand the details and consequences of these assumptions. We construct a simple network model for an environmentally-transmitted pathogen and rigorously derive systems of ordinary differential equations (ODEs) based on different assumptions. We explore two key assumptions, namely homogeneity and independence, and demonstrate that relaxing these assumptions can lead to more accurate ODE approximations. We compare these ODE models to a stochastic implementation of the network model over a variety of parameters and network structures, demonstrating that with fewer restrictive assumptions we are able to achieve higher accuracy in our approximations and highlighting more precisely the errors produced by each assumption. We show that less restrictive assumptions lead to more complicated systems of ODEs and the potential for unstable solutions. Due to the rigour of our derivation, we are able to identify the reason behind these errors and propose potential resolutions.
Building a Corpus of Task-Based Grading and Feedback Systems for Learning and Teaching Programming
Authors: Strickroth Sven , Striewe Michael
Published: November 2022

Using grading and feedback systems in the context of learning and teaching programming is quite common. During the last 20 to 40 years research results on several hundred systems and approaches have been published. Existing papers may tell researchers what works well in terms of educational support and how to make a grading and feedback system stable, extensible, secure, or sustainable. However, finding a solid basis for such kind of research is hard due to the vast amount of publications from a very diverse community. Hardly any recent systematic review includes data from more than 100 systems (most include less than 30). Hence, the authors started an endeavor to build a corpus of all task-based grading and feedback systems for learning and teaching programming that deal with source code and have been published in recent years. The intention is to provide the community with a solid basis for their research. The corpus is also designed to be updated and extended by the community with future systems. This paper describes the process of building the corpus and presents some meta-analysis that shed light on the involved research communities.
Apprentissages algébriques
Authors: Duval Raymond , Pluvinage François
Published: November 2022

This first article of a series of two presents on teaching elementary algebra different standpoints, not always easy to reconcile with each other; a second article will cover activities to promote the learning of algebra. The expectations expressed by the institution on this learning are determined by the common uses of algebra in everyday or professional life, such as the introduction and use of formulas in a spreadsheet. But the results observed at the end of compulsory schooling are clearly insufficient. From a cognitive standpoint, the phased curriculum of algebra does not appear satisfactory, especially not taking into account the difference between symbolic writing and the natural language. The historical view shows, before the use of algebraic notation, the use of algorithmic processes significantly more advanced than the beginnings of algebra, so difficult to transpose in education; but it also points out that following the invention of printing, writing algebraic and relative numbers have arisen simultaneously, which deserves consideration for teaching algebra. Our analysis of the treatment required by algebraic problem solving first highlights the role of the functional designation, next to the direct designation, and the crucial importance of a commonly misunderstood operation, namely that of renaming considered objects. Then arose the fundamental semiotic distinction for analyzing the specific cognitive functioning for processing complete expressions in algebra, namely between a sign and its occurrences.
Une étude comparative de l’enseignement du calcul algébrique en France et au Chili
Authors: Coulange Lalina , Verdugo Paula
Published: November 2022

In this paper, we present the results of a comparative study on the teaching of algebra in France and in Chili. Within the Anthropological Theory of the Didactic, we studied and compared the mathematical knowledge related to the distributive property, taught within each school system. The analysis of programs and textbooks reveals significant differences in the knowledge to be taught or taught. We also analyzed the knowledge of students, through a questionnaire given to French and Chilean students (aged 14-15). The analysis of the answers allows us to establish differences between the mathematical praxeologies students have learnt. It also reveals similarities that reveal the difficulties of (Chilean or French) students in learning algebra. Finally, we conducted a brief experimentation in a French class that introduced a type of tasks present in the Chilean textbook. This experimentation allows us to examine the role of geometric framework in the study of the distributive property, more represented in the knowledge to be taught and taught in Chile than in France.
Formation initiale des enseignants du premier degré en géométrie : quels savoirs ?
Authors: Barrier Thomas , Mathé Anne-Cécile , Mithalal Joris
Published: November 2022

The context of the research is initial primary school teacher education in geometry. We study and compare three implementations of a collectively designed training sequence by three trainers with distinct status and/or research interest. We highlight some variations in the knowledge that the trainers institutionalize, with a specific focus on figure visualization. The research background concerns the potential effects of those variations on teacher training.
« De vivants commentaires à toute cette archéologie glacée » : usages d’Apulée et d’Augustin dans les imaginaires modernes de l’Algérie
Authors: Boidin Carole
Published: November 2022

Dans le cadre d’une réflexion sur les identités locales dans l’Afrique du Nord romaine, cet article examine comment cet enjeu a partie liée avec les débats identitaires contemporains et l’histoire de la région. En étudiant la réception des figures d’Apulée et d’Augustin en Algérie, depuis l’époque coloniale jusqu’à nos jours, on remarque combien la question de la latinité de ces auteurs s’y pose de manière complexe, puisqu’elle a partie liée avec ce passé colonial et qu’elle est discutée jusque dans les polémiques entourant les revendications amazighes ou la place du religieux. Apulée et Augustin y ont fait l’objet de travaux scientifiques, de discours politiques et d’une imagerie culturelle où se déploient des stratégies d’appropriation qui influencent la lecture de leurs œuvres.
Notes sur le statut de la tragédie dans la conception freudienne de l’homme
Authors: Fernandez de Souza Pedro
Published: November 2022

Chez Freud, l’antiquité grecque surgit non seulement en tant qu’objet d’un intérêt constant, mais aussi comme une vraie toile de fond de sa théorisation. Le complexe d’Œdipe, le fruit majeur de cette centralité de la Grèce classique chez Freud, fit l’objet de diverses critiques en ce qui concerne la manière dont il aborda et travailla la tragédie grecque. Dans cet article, nous partons d’une de ces critiques (celle de l’«  innocence d’Œdipe  ») pour étudier le statut de la tragédie grecque au sein de la conception freudienne de l’homme. C’est alors que la centralité de la tragédie révèle ses principaux contours, et la psychanalyse freudienne émerge comme une sorte de mise en scène et réinterprétation, profanes, des trames sophocléennes.
Comment Tamerlan a pris Alep en 803/1400
Authors: Vigouroux Élodie
Published: November 2022

À la fin du xive siècle le conquérant turco‑mongol Tamerlan menaçait le sultanat mamelouk. En 1400, après s’être emparé de plusieurs villes d’Anatolie, il assiégea Alep. La cité, pourtant défendue par tous les gouverneurs de Syrie, fut investie par les troupes tatares après quelques escarmouches. En outre, sa célèbre citadelle se rendit après un siège de trois jours. Pour l’historiographie du xxe siècle, la prise d’Alep ne fut qu’un épisode passager, aux conséquences limitées. La confrontation de textes d’origines différentes permet aujourd’hui de réexaminer cet évènement. Le présent article vise à interroger les raisons de cette conquête éclair, en proposant une reconstitution des faits, et à mettre en lumière les conséquences de l’occupation tatare sur la ville et ses habitants.
P.Cair.EgLib. 513: A Certificate for a Ziyāra to the Prophet’s Tomb in Medina (16th century)
Authors: Martín Sergio Carro
Published: November 2022

This article presents a hitherto unpublished document preserved at Dār al‑Kutub al‑Miṣriyya (Cairo) under inventory number P.Cair.EgLib.inv. 513. The document extols the holy city of Medina and contains a diagrammatic representation of the Prophet’s mosque (al‑masǧid al‑nabawī) comparable to other illustrated scrolls dated to the sixteenth century. The material, textual and iconographic characteristics of this document raise the possibility that it could be the draft of a ziyāra certificate attesting to a pious visit to the tomb of Muḥammad in Medina.
Le palmier et le grenadier dans les romans de Sinan Antoon : renversement de deux symboles à la croisée des religions
Authors: Rubino Marcella
Published: November 2022

Dans les romans de Sinan Antoon, un des auteurs les plus connus de l’Irak contemporain, certains éléments paysagers contribuent à la construction du codage référentiel du texte en lien direct avec l’imaginaire du lecteur et sont investis donc d’une fonction esthétique importante. C’est le cas notamment de deux arbres, le grenadier et le palmier. Si les symboles liés à ces derniers nourrissent un répertoire commun à l’ensemble du monde arabo-islamique, ils acquièrent une résonance particulière dans ces romans, où ils illustrent la volonté de construire une esthétique se situant au-dessus de tout clivage culturel, confessionnel, idéologique. Symboles universels rattachés à la vie, dans les romans Waḥdahā šaǧarat al‑rummān [Seul le grenadier] et Yā Maryam [Ave Maria] ces deux arbres assument ainsi des significations spécifiques : le grenadier du laveur de morts devient le symbole de la continuité entre la vie et la mort dans un contexte où cette dernière est omniprésente, tandis que le palmier, personnification de l’individu, témoigne à travers son dépérissement et sa destruction, de la tragédie irakienne.