bluuebunny/crossref_metadata_2025 huggingface dataset:
Author Correction: Volcanic influence on centennial to millennial Holocene Greenland temperature change
Authors: Kobashi Takuro , Menviel Laurie , Jeltsch-Thömmes Aurich , Vinther Bo M. , Box Jason E. , Muscheler Raimund , Nakaegawa Toshiyuki , Pfister Patrik L. , Döring Michael , Leuenberger Markus , Wanner Heinz , Ohmura Atsumu
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Author Correction: Molecular mechanisms involved in the non-monotonic effect of bisphenol-a on Ca2+ entry in mouse pancreatic β-cells
Authors: Villar-Pazos Sabrina , Martinez-Pinna Juan , Castellano-Muñoz Manuel , Alonso-Magdalena Paloma , Marroqui Laura , Quesada Ivan , Gustafsson Jan-Ake , Nadal Angel
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Author Correction: Enhanced antiviral and antifibrotic effects of short hairpin RNAs targeting HBV and TGF-β in HBV-persistent mice
Authors: Ye Lei , Kan Fangming , Yan Tao , Cao Jiaqi , Zhang Leiliang , Wu Zhijian , Li Wuping
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Publisher Correction: Novel selective, potent naphthyl TRPM8 antagonists identified through a combined ligand- and structure-based virtual screening approach
Authors: Beccari Andrea R. , Gemei Marica , Lo Monte Matteo , Menegatti Nazareno , Fanton Marco , Pedretti Alessandro , Bovolenta Silvia , Nucci Cinzia , Molteni Angela , Rossignoli Andrea , Brandolini Laura , Taddei Alessandro , Za Lorena , Liberati Chiara , Vistoli Giulio
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Author Correction: A method to generate small-scale, high-resolution sedimentary bedform architecture models representing realistic geologic facies
Authors: Meckel T. A. , Trevisan L. , Krishnamurthy P. G.
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Publisher Correction: Quaternary history, population genetic structure and diversity of the cold-adapted Alpine newt Ichthyosaura alpestris in peninsular Italy
Authors: Chiocchio Andrea , Bisconti Roberta , Zampiglia Mauro , Nascetti Giuseppe , Canestrelli Daniele
Published: March 2018

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Author Correction: Unraveling the roles of CD44/CD24 and ALDH1 as cancer stem cell markers in tumorigenesis and metastasis
Authors: Li Wenzhe , Ma Huailei , Zhang Jin , Zhu Ling , Wang Chen , Yang Yanlian
Published: March 2018

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Increased intracellular activity of MP1102 and NZ2114 against Staphylococcus aureus in vitro and in vivo
Authors: Wang Xiao , Wang Xiumin , Teng Da , Mao Ruoyu , Hao Ya , Yang Na , Li Zhanzhan , Wang Jianhua
Published: March 2018

Treatment of Staphylococcus aureus infections remains very difficult due to its capacity to survive intracellularly and its multidrug resistance. In this study, the extracellular/intracellular activities of plectasin derivatives-MP1102/NZ2114 were investigated against three methicillin-susceptible/-resistant S. aureus (MSSA/MRSA) strains in RAW 264.7 macrophages and mice to overcome poor intracellular activity. Antibacterial activities decreased 4–16-fold under a mimic phagolysosomal environment. MP1102/NZ2114 were internalized into the cells via clathrin-mediated endocytosis and macropinocytosis and distributed in the cytoplasm; they regulated tumor necrosis factor-α, interleukin-1β and interleukin-10 levels. The extracellular maximal relative efficacy (Emax) values of MP1102/NZ2114 towards the three S. aureus strains were >5-log decrease in colony forming units (CFU). In the methicillin-resistant and virulent strains, MP1102/NZ2114 exhibited intracellular bacteriostatic efficacy with an Emax of 0.42–1.07-log CFU reduction. In the MSSA ATCC25923 mouse peritonitis model, 5 mg/kg MP1102/NZ2114 significantly reduced the bacterial load at 24 h, which was superior to vancomycin. In MRSA ATCC43300, their activity was similar to that of vancomycin. The high virulent CVCC546 strain displayed a relatively lower efficiency, with log CFU decreases of 2.88–2.91 (total), 3.41–3.50 (extracellular) and 2.11–2.51 (intracellular) compared with vancomycin (3.70). This suggests that MP1102/NZ2114 can be used as candidates for treating intracellular S. aureus.
Publisher Correction: Functionalized Non-vascular Nitinol Stent via Electropolymerized Polydopamine Thin Film Coating Loaded with Bortezomib Adjunct to Hyperthermia Therapy
Authors: Aguilar Ludwig Erik , Tumurbaatar Batgerel , Ghavaminejad Amin , Park Chan Hee , Kim Cheol Sang
Published: March 2018

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Publisher Correction: Acute Psychological Stress Disrupts Attentional Bias to Threat-Related Stimuli
Authors: Jiang Caihong , Buchanan Tony W. , Yao Zhuxi , Zhang Kan , Wu Jianhui , Zhang Liang
Published: March 2018

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Publisher Correction: Exfoliated WS2-Nafion Composite based Electromechanical Actuators
Authors: Loeian Masoud S. , Ziolkowska Dominika A. , Khosravi Farhad , Jasinski Jacek B. , Panchapakesan Balaji
Published: March 2018

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Publisher Correction: Paracrine interactions between mesenchymal stem cells and macrophages are regulated by 1,25-dihydroxyvitamin D3
Authors: Saldaña Laura , Vallés Gema , Bensiamar Fátima , Mancebo Francisco José , García-Rey Eduardo , Vilaboa Nuria
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
High-affinity ligands of the colchicine domain in tubulin based on a structure-guided design
Authors: Bueno Oskía , Estévez Gallego Juan , Martins Solange , Prota Andrea E. , Gago Federico , Gómez-SanJuan Asier , Camarasa María-José , Barasoain Isabel , Steinmetz Michel O. , Díaz J. Fernando , Pérez-Pérez María-Jesús , Liekens Sandra , Priego Eva-María
Published: March 2018

Microtubule-targeting agents that bind at the colchicine-site of tubulin are of particular interest in antitumoral therapy due to their dual mechanism of action as antimitotics and vascular disrupting agents. Cyclohexanediones derivatives have been described as a new family of colchicine-domain binders with an association constant to tubulin similar to that of colchicine. Here, the high-resolution structures of tubulin in complex with cyclohexanediones TUB015 and TUB075 were solved by X-ray crystallography. A detailed analysis of the tubulin-TUB075 interaction by means of computational affinity maps allowed the identification of two additional regions at the binding site that were addressed with the design and synthesis of a new series of cyclohexanediones with a distal 2-substituted benzofurane. These new compounds showed potent antiproliferative activity with IC50 values in the nM range, arrested cell cycle progression at the G2/M phase and induced apoptosis at sub μM concentrations. Moreover, they caused the destruction of a preformed vascular network in vitro and inhibited the migration of endothelial cells at non-toxic concentrations. Finally, these compounds displayed high affinity for tubulin as substantiated by a K
b
value of 2.87 × 108 M−1 which, to the best of our knowledge, represents the highest binding constant measured to date for a colchicine-domain ligand.
Intensify3D: Normalizing signal intensity in large heterogenic image stacks
Authors: Yayon Nadav , Dudai Amir , Vrieler Nora , Amsalem Oren , London Michael , Soreq Hermona
Published: March 2018

Three-dimensional structures in biological systems are routinely evaluated using large image stacks acquired from fluorescence microscopy; however, analysis of such data is muddled by variability in the signal across and between samples. Here, we present Intensify3D: a user-guided normalization algorithm tailored for overcoming common heterogeneities in large image stacks. We demonstrate the use of Intensify3D for analyzing cholinergic interneurons of adult murine brains in 2-Photon and Light-Sheet fluorescence microscopy, as well as of mammary gland and heart tissues. Beyond enhancement in 3D visualization in all samples tested, in 2-Photon in vivo images, this tool corrected errors in feature extraction of cortical interneurons; and in Light-Sheet microscopy, it enabled identification of individual cortical barrel fields and quantification of somata in cleared adult brains. Furthermore, Intensify3D enhanced the ability to separate signal from noise. Overall, the universal applicability of our method can facilitate detection and quantification of 3D structures and may add value to a wide range of imaging experiments.
A Facile Approach to Prepare Multiple Heteroatom-Doped Carbon Materials from Imine-Linked Porous Organic Polymers
Authors: Yang Juan , Xu Min , Wang Jingyu , Jin Shangbin , Tan Bien
Published: March 2018

In this paper, we proposed a new strategy to prepare multiple heteroatom doped (N,P-doped) porous carbon materials with high surface area of ~1,535 m2g−1simply by pyrolysis of imine-linked porous organic polymers (POPs) synthesizedviaSchiff base condensation. The strategy is simple without any post-processing and various heteroatoms could be involved. Scanning electron microscopy, Raman spectra, Nitrogen gas adsorption-desorption, X-ray photoelectron spectroscopy have been used to characterize the morphology, the structure and the composition of the materials. The multiple heteroatom doped porous carbon materials also display high electrocatalytic performance as exampled by the application in oxygen reduction, which showed the catalyst favors 4-electron transfer during the process, along with superior stability and higher tolerance to methanol as compared to the Pt/C. These results indicate the present method is promising for the preparation of multi-heteroatom doped carbon materials in the application of electrocatalysis.
Author Correction: White matter microstructural changes are related to cognitive dysfunction in essential tremor
Authors: Benito-León Julián , Mato-Abad Virginia , Louis Elan D. , Hernández-Tamames Juan Antonio , Álvarez-Linera Juan , Bermejo-Pareja Félix , Domingo-Santos Ángela , Collado Luis , Romero Juan Pablo
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has not been fixed in the paper.
Author Correction: Knowledge graph prediction of unknown adverse drug reactions and validation in electronic health records
Authors: Bean Daniel M. , Wu Honghan , Iqbal Ehtesham , Dzahini Olubanke , Ibrahim Zina M. , Broadbent Matthew , Stewart Robert , Dobson Richard J. B.
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Publisher Correction: The polyglutamine protein ataxin-3 enables normal growth under heat shock conditions in the methylotrophic yeast Pichia pastoris
Authors: Bonanomi Marcella , Roffia Valentina , De Palma Antonella , Lombardi Alessio , Aprile Francesco Antonio , Visentin Cristina , Tortora Paolo , Mauri Pierluigi , Regonesi Maria Elena
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Reactive oxygen species stress increases accumulation of tyrosyl-DNA phsosphodiesterase 1 within mitochondria
Authors: Fam Hok Khim , Choi Kunho , Fougner Lauren , Lim Chinten James , Boerkoel Cornelius F.
Published: March 2018

Tyrosyl-DNA phosphodiesterase 1 (Tdp1) is a nuclear and mitochondrial protein that in nuclei and in vitro repairs blocked 3′ DNA termini such as 3′ phosphotyrosine conjugates resulting from stalling of topoisomerase I-DNA intermediates. Its mutation also causes spinocerebellar ataxia with axonal neuropathy type 1 (SCAN1). Because Tdp1 colocalizes with mitochondria following oxidative stress, we hypothesized that Tdp1 repairs mitochondrial DNA (mtDNA) and that mtDNA damage mediates entry of Tdp1 into the mitochondria. To test this, we used S. cerevisiae mutants, cultured mouse and human cells, and a Tdp1 knockout mouse. H2O2- and rotenone-induced cellular and intramitochondrial reactive oxygen species (ROS) activated oxidant-responsive kinases P38 and ERK1, and the translocation of Tdp1 from the nucleus to the mitochondria via the TIM/TOM complex. This translocation occurred independently of mtDNA. Within the mitochondria, Tdp1 interacted with Ligase III and reduced mtDNA mutations. Tdp1-deficient tissues had impaired mitochondrial respiration and decreased viability. These observations suggest that Tdp1 maintains mtDNA integrity and support the hypothesis that mitochondrial dysfunction contributes to the pathology of SCAN1.
The dose-response analysis between BMI and common chronic diseases in northeast China
Authors: Yu Jianxing , Tao Yuchun , Dou Jing , Ye Junsen , Yu Yaqin , Jin Lina
Published: March 2018

High body mass index (BMI) predisposes to several chronic diseases, but a large-scale systematic and detailed study of dose-response relationship between BMI and chronic diseases has not been reported previously. In this study, we aimed to investigate the relationship between BMI and 3 chronic diseases (hypertension, dyslipidemia and MetS) in northeast China. A sample of 16412 participants aged 18~79 years old were included in Jilin province in 2012. The lambda-mu-sigma (LMS) method was applied to examine the trend of BMI by age, and the restricted cubic splines were used to investigate the non-linear associations (dose-response curve) between BMI and chronic diseases. It was pointed out that BMI increased rapidly when young, then kept steady in middle age, and finally declined slowly in old age, and accordingly age was divided into 3 segments, which were different by gender. The odds ratios (ORs) of BMI for the chronic diseases increased relatively slowly when young, then increased dramatically in middle-age and old population, especially for men. Further, the ORs of BMI among non-smokers were lower than those among smokers, and the same trend was shown to be more apparent among drinkers and non-drinkers. The risk of BMI for common chronic diseases increased dramatically in middle-aged, especially for men with drinking and smoking habits.
Identifying temporal patterns in patient disease trajectories using dynamic time warping: A population-based study
Authors: Giannoula Alexia , Gutierrez-Sacristán Alba , Bravo Álex , Sanz Ferran , Furlong Laura I.
Published: March 2018

Time is a crucial parameter in the assessment of comorbidities in population-based studies, as it permits to identify more complex disease patterns apart from the pairwise disease associations. So far, it has been, either, completely ignored or only, taken into account by assessing the temporal directionality of identified comorbidity pairs. In this work, a novel time-analysis framework is presented for large-scale comorbidity studies. The disease-history vectors of patients of a regional Spanish health dataset are represented as time sequences of ordered disease diagnoses. Statistically significant pairwise disease associations are identified and their temporal directionality is assessed. Subsequently, an unsupervised clustering algorithm, based on Dynamic Time Warping, is applied on the common disease trajectories in order to group them according to the temporal patterns that they share. The proposed methodology for the temporal assessment of such trajectories could serve as the preliminary basis of a disease prediction system.
Ultraviolet-irradiated endothelial cells secrete stem cell factor and induce epidermal pigmentation
Authors: Kim Misun , Shibata Takako , Kwon Soohyun , Park Tae Jun , Kang Hee Young
Published: March 2018

Ultraviolet (UV)-associated hyperpigmented skins are characterized with increased vasculature underlying pigmentation, suggestive of the possible biological role of endothelial cells in the regulation of skin pigmentation during UV irradiation. In this study, we showed that UV-irradiated endothelial cells significantly increased the pigmentation of melanocytes through epithelial-mesenchymal crosstalk. The stimulatory effect of endothelial cells was further demonstrated usingex vivohuman skin. RNA sequence analysis and enzyme-linked immunosorbent assay showed that endothelial cells secrete more stem cell factor (SCF) upon UV irradiation than non-irradiated cells. The increased pigmentation elicited by endothelial cells was abrogated following inhibition of SCF/c-KIT signaling. Together these results suggest that endothelial cells are activated upon UV exposure to release melanogenic factors such as SCF, which contributes to the development of skin hyperpigmentation during chronic sun exposure.
An optical system via liquid crystal photonic devices for photobiomodulation
Authors: Chang Chia-Ming , Lin Yi-Hsin , Srivastava Abhishek Kumar , Chigrinov Vladimir Grigorievich
Published: March 2018

Photobiomodulation or low-level light therapy (LLLT) has extensive applications based on light-induced effects in biological systems. Photobiomodulation remains controversial because of a poorly understood biochemical mechanism limited by the well-known biphasic dose response or Arndt-Schulz curve. The Arndt-Schulz curve states that an optimal dose of light is a key factor for realizing a therapeutic effect. In this report, we demonstrate a tunable optical system for photobiomodulation to aid physicians in overcoming the constraints of light due to biphasic dose response. The tunable optical system is based on a white light-emitting diode and four liquid crystal (LC) photonic devices: three LC phase retarders, and one LC lens. The output light of the tunable optical system exhibits electrical tunability for the wavelength, energy density and beam size. The operating principle is introduced, and the experimental results are presented. The proposed concept can be further extended to other electrically tunable photonic devices for different clinical purposes for photobiomodulation.
Author Correction: Quantifying the anisotropy and tortuosity of permeable pathways in clay-rich mudstones using models based on X-ray tomography
Authors: Backeberg Nils R. , Iacoviello Francesco , Rittner Martin , Mitchell Thomas M. , Jones Adrian P. , Day Richard , Wheeler John , Shearing Paul R. , Vermeesch Pieter , Striolo Alberto
Published: March 2018

A correction to this article has been published and is linked from the HTML and PDF versions of this paper. The error has been fixed in the paper.
Purkinje cell BKchannel ablation induces abnormal rhythm in deep cerebellar nuclei and prevents LTD
Authors: Cheron Guy , Márquez-Ruiz Javier , Cheron Julian , Prigogine Cynthia , Ammann Claudia , Lukowski Robert , Ruth Peter , Dan Bernard
Published: March 2018

Purkinje cells (PC) control deep cerebellar nuclei (DCN), which in turn inhibit inferior olive nucleus, closing a positive feedback loop via climbing fibers. PC highly express potassium BK channels but their contribution to the olivo-cerebellar loop is not clear. Using multiple-unit recordings in alert mice we found in that selective deletion of BK channels in PC induces a decrease in their simple spike firing with a beta-range bursting pattern and fast intraburst frequency (~200 Hz). To determine the impact of this abnormal rhythm on the olivo-cerebellar loop we analyzed simultaneous rhythmicity in different cerebellar structures. We found that this abnormal PC rhythmicity is transmitted to DCN neurons with no effect on their mean firing frequency. Long term depression at the parallel-PC synapses was altered and the intra-burst complex spike spikelets frequency was increased without modification of the mean complex spike frequency in BK-PC−/−mice. We argue that the ataxia present in these conditional knockout mice could be explained by rhythmic disruptions transmitted from mutant PC to DCN but not by rate code modification only. This suggests a neuronal mechanism for ataxia with possible implications for human disease.
Investigation of 12 X-STR loci in Mongolian and Eastern Han populations of China with comparison to other populations
Authors: Tao Ruiyang , Zhang Jiashuo , Bian Yingnan , Dong Rixia , Liu Xiling , Jin Chao , Zhu Ruxin , Zhang Suhua , Li Chengtao
Published: March 2018

Due to the unique inheritance pattern, X-chromosomal short tandem repeats (X-STRs) have several advantages in complex kinship cases, such as deficiency cases or grandparent-grandchild and half-sisters testing. In our study, 541 unrelated individuals gathered from Mongolian and Eastern Chinese Han populations were successfully genotyped using the Investigator Argus X-12 kit. We calculated allele/haplotype frequencies and other forensic parameters of the two populations and further explored their genetic distance with already published Chinese populations and six global populations. Our results showed that the 12 X-STR markers were highly informative in the two populations when compared with nine other Chinese populations: significant differences were found at several loci. Geographically neighboring populations or different ethnic groups within the same area appeared to have closer evolutionary relationships. We also analyzed population genetic structure by performing clustering with the STRUCTURE program and Principal Coordinate Analysis (PCoA), and we found that the Chinese and other populations enrolled in this study could be distinguished. Furthermore, Mongolian males were distinguishable from the other studied males by a moderate genetic distance. Our study also expanded the X-STR database, which could facilitate the appropriate application of the 12 X-STR markers in the forensic field in China.
Latent class modeling to compare testing platforms for detection of antibodies against the Chlamydia trachomatis antigen Pgp3
Authors: Wiegand Ryan E. , Cooley Gretchen , Goodhew Brook , Banniettis Natalie , Kohlhoff Stephan , Gwyn Sarah , Martin Diana L.
Published: March 2018

Latent class modeling can be used to combine the results of multiple tests to compare the sensitivity and specificity of those tests in the absence of a gold standard. Seroepidemiology for chlamydia infection may be useful for determining the cumulative risk of infection within a population. Initial studies using theChlamydia trachomatisimmunodominant antigen Pgp3 have shown utility for seroepidemiology of sexually transmitted chlamydia and the eye disease trachoma. We present our latent class modeling results for comparison of antibody data obtained from three different Pgp3-based platforms – multiplex bead array, ELISA, and lateral flow assay. Sensitivity and specificity estimates from the best fitting latent class models were similar to estimates derived from those previously obtained using a nucleic acid amplification test as a gold standard for sensitivity and non-endemic pediatric specimens for specificity, although the estimates from latent class models had wider confidence intervals. The modeling process and evaluation highlighted the importance of including as many antibody tests as possible when fitting a latent class model to ensure that as many patterns as possible are available for evaluation. Future studies designed to evaluate antibody test performance in the absence of a gold standard should utilize as many tests as possible.
Suspension Palatoplasty for Obstructive Sleep Apnea- A Preliminary Study
Authors: Li Hsueh-Yu , Lee Li-Ang , Kezirian Eric J. , Nakayama Meiho
Published: March 2018

Suspension palatoplasty, a new surgical technique to treat obstructive sleep apnea (OSA), has been developed to correct the retropalatal obstruction in patients with small tonsils (grade I/II) and anterior-posterior palatal (A-P) obstruction. The objecteive of this preliminary study was to investigate the effectiveness and change in retropalatal airway dimensions after suspension palatoplasty. This retrospective case series study included 25 consecutive male adults with OSA. Unique technical features of suspension palatoplasty are exposure of pterygomandibular raphe and suspension of palatopharyngeus muscle to the raphe. Six months after suspension palatoplasty, apnea-hyponea index significantly reduced from 39.8 to 15.1 (effect size = 1.6). None experienced postoperative bleeding and velopharyngeal insufficiency 1 month following surgery. Subjective snoring severity (visual analogue scale) and daytime sleepiness (the Epworth Sleepiness Scale) significantly improved (8.7 vs 2.0 and 10.2 vs 4.9, respectively). A-P dimension of the retropalatal airspace widened significantly on perioperative endoscopy (23.0 units vs 184.6 unites) as well as posterior air space in cephalometry (7.6 mm vs 10.2 mm). Our preliminary findings show that suspension palatoplasty seems to be an effective OSA surgery in the specific patient population with minimal complications, however, further studies including a large number of patients are required to confirm the findings.
Evaluation of the nutrition and function of cow and goat milk based on intestinal microbiota by metagenomic analysis
Authors: Wang Zhaoxia , Jiang Shuaiming , Ma Chenchen , Huo Dongxue , Peng Qiannan , Shao Yuyu , Zhang Jiachao
Published: March 2018

A high-throughput 16S rRNA sequencing technology was applied to study changes of the intestinal microbiota in mice after the administration of cow and goat milk. We show a correlation between the gut microbiota and the nutrients in milk.
Complementary effects of cereal and pulse polyphenols and dietary fiber on chronic inflammation and gut health
Authors: Awika Joseph M. , Rose Devin J. , Simsek Senay
Published: March 2018

Cereal and pulse polyphenols and dietary fiber offer a wealth of complementary health benefits.
Moving corrole towards a red-record: synthesis of β-acrolein Ga and Cu corroles using the Vilsmeier reaction
Authors: Savoldelli A. , Nardis S. , Genovese D. , Prodi L. , Fronczek F. R. , Smith K. M. , Paolesse R.
Published: March 2018

Pioneering the red region of emission! β-acrolein substituted Ga corroles show the longest fluorescence emission reported for monomeric corroles.
Upconversion thermometry: a new tool to measure the thermal resistance of nanoparticles
Authors: Savchuk O. A. , Carvajal J. J. , Brites C. D. S. , Carlos L. D. , Aguilo M. , Diaz F.
Published: March 2018

We demonstrated that KLu(WO4)2:Ho3+,Tm3+ nanoparticles are able to combine controllable heat release and upconversion thermometry permitting to estimate the thermal resistance of the nanoparticles in air, a key parameter to model the heat transfer at the nanoscale.
Preparation and characterization of polyamide 6 fibre based on a phosphorus-containing flame retardant
Authors: Liu Ke , Li Yuanyuan , Tao Lei , Xiao Ru
Published: March 2018

Intrinsically flame retardant polyamide 6 (FRPA6) was synthesized by melt polycondensation of caprolactam and 9,10-dihydro-10-[2,3-di(hydroxycarbonyl)propyl]-10-phosphaphenanthrene-10-oxide (DDP). And the FRPA6 fibres were prepared by melt spinning.
Trends in activity for the oxygen evolution reaction on transition metal (M = Fe, Co, Ni) phosphide pre-catalysts
Authors: Xu Junyuan , Li Junjie , Xiong Dehua , Zhang Bingsen , Liu Yuefeng , Wu Kuang-Hsu , Amorim Isilda , Li Wei , Liu Lifeng
Published: March 2018

A notable trend in OER activity on transition metal phosphide pre-catalysts is reported. Remarkably, the tri-metallic FeCoNiP pre-catalysts exhibit exceptional apparent and intrinsic OER activities, outperforming many non-precious OER catalysts reported previously.
Unexpected solvation-stabilisation of ions in a protic ionic liquid: insights disclosed by a bond energetic study
Authors: Wang Zhen , Gao Feixiang , Ji Pengju , Cheng Jin-Pei
Published: March 2018

Accurate acidity studies of different families of substrates in a pure protic ionic liquid (PIL) show that solute ions in the PIL are free from specific ion associations and the solvation behaviour of PILs is closely related to the number of dissociable protons.
Kirigami enhances film adhesion
Authors: Zhao Ruike , Lin Shaoting , Yuk Hyunwoo , Zhao Xuanhe
Published: March 2018

Kirigami enhances film adhesion due to (i) the shear-lag effect of the film segments; (ii) partial debonding at the film segments’ edges; and (iii) compatibility of kirigami films with inhomogeneous deformation of substrates.
Fluorescence sensing of mercury(ii) and melamine in aqueous solutions through microwave-assisted synthesis of egg-white-protected gold nanoclusters
Authors: Lin Ying-Chiao , Wu Tsunghsueh , Lin Yang-Wei
Published: March 2018

Microwave-assisted synthesis of fluorescent egg-white-protected gold nanoclusters for turn-off sensing of Hg(ii) and turn-on sensing of melamine.
Gold nanoparticles as an outstanding catalyst for the hydrogen evolution reaction
Authors: Tran Tien D. , Nguyen Mai T. T. , Le Hoang V. , Nguyen Duc N. , Truong Quang Duc , Tran Phong D.
Published: March 2018

An electrode made of Au nanoparticles, ca. 13 nm in diameter, displays outstanding catalytic activity for the hydrogen evolution reaction in water.
Enhanced measurement of residual chemical shift anisotropy for small molecule structure elucidation
Authors: Liu Yizhou , Cohen Ryan D. , Gustafson Kirk R. , Martin Gary E. , Williamson R. Thomas
Published: March 2018

A simple strategy is introduced to accurately measure residual chemical shift anisotropies (RCSAs) from strong molecular alignment in the mesophase of poly-γ-(benzyl-l-glutamate). The improved data quality greatly enhances the utility of RCSA in small molecule structure analysis.
Room temperature-formed iron-doped nickel hydroxide on nickel foam as a 3D electrode for low polarized and high-current-density oxygen evolution
Authors: Guo Chun Xian , Li Chang Ming
Published: March 2018

Room temperature-formed iron-doped nickel hydroxide on Ni foam as a 3D electrode with fast gas dissipation and a high oxidation state of Ni for a high-performance oxygen evolution reaction is presented.
Convergent synthesis of trifunctional molecules by three sequential azido-type-selective cycloadditions
Authors: Yoshida Suguru , Kanno Kimiyuki , Kii Isao , Misawa Yoshihiro , Hagiwara Masatoshi , Hosoya Takamitsu
Published: March 2018

A facile strategy for the synthesis of trifunctional molecules involving three selective triazole-forming reactions is proposed. Three sequential azido-type-selective cycloadditions allowed for efficient connection of three different azidophiles to a triazido platform molecule.
Crystal structural analysis of methyl-substituted pyrazines with anilic acids: a combined diffraction, inelastic neutron scattering,1H-NMR study and theoretical approach
Authors: Rok M. , Bator G. , Sawka-Dobrowolska W. , Durlak P. , Moskwa M. , Medycki W. , Sobczyk L. , Zamponi M.
Published: March 2018

The molecular complexes of the pyrazine derivatives with anilic acids were analyzed in terms of the structure of molecules, the vibrational spectra, INS,1HNMR and theoretical approach.
Proton-induced collision dynamics on potential prebiotic sulfur species
Authors: Bacchus-Montabonel Marie-Christine
Published: March 2018

The role of sulfur in proton-induced charge transfer is analyzed through an ab initio theoretical study of mercaptoacetonitrile HSCH2CN with related HCN oligomers.
An ion exchange approach assembled multi-dimensional hierarchical Fe–TiO2composite micro-/nano multi-shell hollow spheres for bacteria lysis through utilizing visible light
Authors: Ang Jeremy Koon Keong , Chua Jestoni Song Mi , Chang Zhong Jie , Li Zhengtao , Bai Hongwei , Sun Darren D.
Published: March 2018

Ion exchange for (a) 6 h Fe penetrated sphere resulting in (b) uncompact pores and (c) loose shells and (d) 24 h Fe penetrated sphere resulting in (e) compact pores and (f) smooth shells.
Theoretical insight into the zinc(ii)-catalyzed synthesis of 2-indolyltetrahydroquinolines from N-propargylanilines and indoles: cross-dehydrogenative coupling with temporally separated catalytic activity
Authors: Wang Hongliang , Dong Mengmeng , Liu Chengbu , Zhang Dongju
Published: March 2018

An abnormal catalytic cascade reaction with temporally separated catalytic activity.
Fast and efficient direct formation of size-controlled nanostructures of coordination polymers based on copper(i)–iodine bearing functional pyridine terminal ligands
Authors: Conesa-Egea Javier , Hassanein Khaled , Muñoz Marta , Zamora Félix , Amo-Ochoa Pilar
Published: March 2018

We report on the direct formation of 1D nanostructures of two coordination polymers based on copper(i)–iodine double chains decorated with ethyl isonicotinate or 2-amino-5-nitropyridine as terminal ligands.
The impact of galactooligosaccharides on the bioaccessibility of sterols in a plant sterol-enriched beverage: adaptation of the harmonized INFOGEST digestion method
Authors: Blanco-Morales Virginia , López-García Gabriel , Cilla Antonio , Garcia-Llatas Guadalupe , Barberá Reyes , Lagarda María Jesús , Sánchez-Siles Luis Manuel , Alegría Amparo
Published: March 2018

Bioaccessibility of sterols in milk-based fruit beverages: comparison of twoin vitrodigestions.
Impact of magnetization and hyperfine field distribution on high magnetoelectric coupling strength in BaTiO3–BiFeO3 multilayers
Authors: Jochum Johanna K. , Lorenz Michael , Gunnlaugsson Haraldur P. , Patzig Christian , Höche Thomas , Grundmann Marius , Vantomme André , Temst Kristiaan , Van Bael Margriet J. , Lazenka Vera
Published: March 2018

Using conversion electron Mössbauer spectroscopy, interesting correlations of hyperfine field, magnetization, polarization, and magnetoelectric coefficient could be established.
Porphyrin-based porous polyimide polymer/Pd nanoparticle composites as efficient catalysts for Suzuki–Miyaura coupling reactions
Authors: Zhu Wei , Wang Xuan , Li Tao , Shen Rui , Hao Si-Jia , Li Yunxing , Wang Qingqing , Li Zaijun , Gu Zhi-Guo
Published: March 2018

Two porphyrin-based porous polyimide polymer/Pd nanoparticle composites were synthesized, which exhibit high stability and excellent catalytic efficiency as Suzuki–Miyaura coupling catalysts.
Thermally induced cationic polymerization of isobutyl vinyl ether in toluene in the presence of solvate ionic liquid
Authors: Hirano Tomohiro , Kizu Ryotaro , Hashimoto Junpei , Munekane Nenji , Miwa Yohei , Oshimura Miyuki , Ute Koichi
Published: March 2018

Cationic polymerization of isobutyl vinyl ether at elevated temperatures of 60–100 °C, in which the propagating cations are stabilized with a solvate ionic liquid, is described.
Inversion of crystallization rates in miscible block copolymers of poly(lactide)-block-poly(2-isopropyl-2-oxazoline)
Authors: Pooch Fabian , Sliepen Marjolein , Svedström Kirsi J. , Korpi Antti , Winnik Françoise M. , Tenhu Heikki
Published: March 2018

From a miscible melt, crystallization drives phase-separation of PLLA-PiPOx. PLLA plasticizes PiPOx and inverts the crystallization rates compared to the homopolymers.
Reinvestigation of the mechanism of polymerization of β-butyrolactone from 1,5,7-triazabicyclo[4.4.0]dec-5-ene
Authors: Moins S. , Henoumont C. , De Winter J. , Khalil A. , Laurent S. , Cammas-Marion S. , Coulembier O.
Published: March 2018

The questionable mechanism initially proposed to explain how 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) allows us to ring-open β-lactones, such as β-butyrolactone (BL), is reinvestigated here.
Mechanisms of TPGS and its derivatives inhibiting P-glycoprotein efflux pump and application for reversing multidrug resistance in hepatocellular carcinoma
Authors: Liu Tengfei , Liu Xiaoyan , Xiong Hui , Xu Cheng , Yao Jianxu , Zhu Xiumei , Zhou Jianping , Yao Jing
Published: March 2018

We have developed a TPGS–GA conjugate and TPGS–LA conjugate which possess more effective P-gp inhibition compared to TPGS because of the enhancement of hydrophilicity and negative charge.
Correction: Ultra-efficient and stable electro-optic dendrimers containing supramolecular homodimers of semifluorinated dipolar aromatics
Authors: Wu Jieyun , Wu Bo , Wang Wen , Chiang Kin Seng , Jen Alex. K.-Y. , Luo Jingdong
Published: March 2018

Correction for ‘Ultra-efficient and stable electro-optic dendrimers containing supramolecular homodimers of semifluorinated dipolar aromatics’ by Jieyun Wu et al., Mater. Chem. Front., 2018, DOI: 10.1039/c8qm00006a.
Synthesis of zeolitic material from basalt rock and its adsorption properties for carbon dioxide
Authors: Hwang Kyung-Jun , Choi Won-Seok , Jung Sung-Hoon , Kwon Young-Jun , Hong Soonkook , Choi Chulmin , Lee Jae-Wook , Shim Wang-Geun
Published: March 2018

A zeolitic 4A type material was successfully prepared from natural basalt rock by applying an alkali fusion process and hydrothermal synthesis.
Polymeric ionic liquid gels composed of hydrophilic and hydrophobic units for high adsorption selectivity of perrhenate
Authors: Han Dong , Li Xingxiao , Cui Yu , Yang Xin , Chen Xibang , Xu Ling , Peng Jing , Li Jiuqiang , Zhai Maolin
Published: March 2018

Polymeric ionic liquid gels composed of hydrophilic and hydrophobic units with high adsorption selectivity towards perrhenate were synthesized.
Theoretical research on novel orthorhombic tungsten dinitride from first principles calculations
Authors: Li Qian , Wang Jianyun , Liu Hanyu
Published: March 2018

We uncovered a novel WN2 structure (Cmc21, 46–113 GPa) which is dynamically stable and ultra-incompressible at atmospheric pressure.
Nouvelles données historiques sur les premiers dinosaures trouvés en France
Authors: Brignon Arnaud
Published: March 2018

Cet article passe en revue les premières découvertes de dinosaures faites en France avant que le terme Dinosauria n’ait été introduit par Richard Owen en 1842. En mettant à part les premières découvertes du théropodeStreptospondylus altdorfensisfaites auXVIIIesiècle par Charles Bacheley dans le Jurassique des Vaches Noires, les principaux résultats démontrés ici sont les suivants (par ordre chronologique) : 1) les premiers restes de dinosaures (dents de théropodes) du Calcaire de Caen (Bathonien) furent collectés par Arcisse de Caumont dans les carrières de Quilly en, ou avant, avril 1826 et la première mention de cette découverte fut publiée en 1827 ; 2) les restes de théropode que William Buckland avait observés en octobre 1826 dans le Cabinet d’Histoire naturelle de Besançon furent signalés dans une publication dès 1830 ; 3) la première mention à un dinosaure du Jurassique supérieur du Boulonnais fut longtemps considérée avoir été celle faite par Constant Prévost en 1839. Des dents d’un théropode et d’un dinosaure herbivore furent, semble-t-il, découvertes dans ces formations par Eugène Robert en automne 1833. Une autre dent de théropode, celle-ci identifiable de manière incontestable, fut collectée en, ou avant, juillet 1835 par Bruno Marmin comme en atteste une lettre inédite à Jules Desnoyers ; 4) Le genrePoekilopleuronEudes-Deslongchamps, 1836 et son espèce typeP. bucklandiiEudes-Deslongchamps, 1836, du Calcaire de Caen (Bathonien moyen), ont été créés de manière valide en 1836 ; 5) l’humérus de sauropode découvert dans le Crétacé supérieur de la plaine de Lisle près de Périgueux et figuré par Paul Gervais en 1852 fut donné au Muséum d’Histoire naturelle à Paris par un certain Simon Bornet en 1841 ; 6) l’humérus de sauropode du grès vert (Albien) de Bédoin près du mont Ventoux, décrit par Gervais en 1852 sous le nom d’Aepisaurus elephantinus, fut découvert par Prosper Renaux en 1841. Ce dernier effectua des dessins du spécimen à partir desquels une lithographie restée inédite fut réalisée. Renaux est ainsi le premier à avoir découvert et étudié un dinosaure, authentifié de manière incontestable, dans le Crétacé provençal. Les affinités de cet os avec les genresMegalosaurusetIguanodonfurent reconnues par Henri Marie Ducrotay de Blainville dès 1842.
Impact of Chronic Cannabis Use on Auditory Mismatch Negativity Generation in Schizophrenia Patients
Authors: Roser Patrik , Pichler Eva-Maria , Habermeyer Benedikt , Kawohl Wolfram , Juckel Georg
Published: March 2018

Introduction Cannabis use disorders (CUD) are highly prevalent among patients with schizophrenia (SCZ). Deficient mismatch negativity (MMN) generation is a characteristic finding in SCZ patients and cannabis users. This study therefore examined the effects of CUD on MMN generation in SCZ patients.

Methods Twenty SCZ − CUD patients, 21 SCZ+CUD patients, and 20 healthy controls (HC) were included in this study. MMN to frequency and duration deviants was elicited within an auditory oddball paradigm and recorded by 32 channel EEG.

Results As expected, SCZ − CUD patients showed reduced frontocentral MMN amplitudes to duration deviants compared to HC. Interestingly, SCZ+CUD patients demonstrated greater MMN amplitudes to duration deviants compared to SCZ − CUD patients at central electrodes with no differences compared to HC.

Discussion These results demonstrate that comorbid cannabis use in SCZ patients might be associated with superior cognitive functioning. It can be assumed that the association between cannabis use and better cognitive performance may be due to a subgroup of cognitively less impaired SCZ patients characterized by lower genetic vulnerability for psychosis.
Ginkgo biloba Food Supplements on the European Market – Adulteration Patterns Revealed by Quality Control of Selected Samples
Authors: Czigle Szilvia , Tóth Jaroslav , Jedlinszki Nikoletta , Háznagy-Radnai Erzsébet , Csupor Dezső , Tekeľová Daniela
Published: March 2018

The aim of this study was to prove whether Ginkgo biloba food supplements on the European market comply with pharmaceutical quality, and whether their composition satisfies the European Pharmacopoeia criteria. Medicinal products containing a standardised Ginkgo leaf extract are used for the improvement of cognitive impairment and quality of life in mild dementia. Further, Ginkgonis folium is used for the treatment of peripheral circulation disorders. Pharmacopoeial Ginkgo dry extract contains 22.0 – 27.0% flavonoids and 5.4 – 6.6% terpene lactones (ginkgolides, bilobalide). In addition to its widespread use as an herbal medicine (herbal medicinal product), the same extract can be an ingredient in food supplements. The content of active secondary metabolites was quantified in a number of European food supplements containing Ginkgo dry extract or Ginkgo leaf. Flavonoids were quantified using a modified pharmacopoeial HPLC-UV method, and terpene lactones (ginkgolides A, B, C, and bilobalide) using LC-MS/MS. Some Ginkgo leaf supplement samples were also analysed by microscopy. The quality of food supplements on the European market is dubious. In this paper, we present selected examples of several methods of adulteration and falsification, including higher/lower doses of Ginkgo dry extract or Ginkgo leaf than declared and the addition of undeclared extraneous materials. These examples reveal several patterns in the manufacturing of adulterated products.
The Synthesis of (–)-Spiroleucettadine
Authors: Lamb Richard , Lessene Guillaume , Hawkins Bill
Published: March 2018

The interesting history of (–)-spiroleucettadine, a marine natural product, is discussed along with some of our original unsuccessful synthetic strategies. Finally, we briefly discuss our reported enantiospecific synthesis of spiroleucettadine, and how we plan to use this as a platform for further studies around this interesting class of molecules.
Rechtskolumne: Live-Übertragung einer Operation verletzt nicht Persönlichkeitsrecht
Authors: Häser Isabel
Published: March 2018

Das Fortbildungsinteresse von Ärzten kann nach einem Urteil des Oberlandesgerichtes Bamberg einen größeren Stellenwert haben als das Persönlichkeitsrecht des Patienten.
Investoren im Gesundheitsmarkt: Kaufpreise steigen spürbar
Authors: Dorner Carola
Published: March 2018

Der Gesundheitssektor wächst – da ist es kein Wunder, dass das Interesse unterschiedlichster Anleger groß ist. Wir haben Michael Gabler, den Leiter Firmenkunden der Deutschen Apotheker- und Ärztebank gefragt, welche Entwicklungen er beobachtet.
Open Notes: Gemeinsame Aktenführung von Ärzten und Patienten
Authors: Gocke Peter
Published: March 2018

Der Wunsch nach einer transparenteren und gemeinsamen Nutzung medizinischer Informationen zwischen Arzt und Patient ist schon seit Jahren Gegenstand von Diskussionen. Mit dem Projekt Open Notes aus den USA ist eine Plattform entstanden, die nach inzwischen mehrjähriger Nutzung zu durchaus positiven Ergebnissen kommt.
Maternal Age at Delivery and Enzyme Polymorphisms in Children with Type 1 Diabetes Mellitus
Authors: Gloria-Bottini Fulvia , Neri Anna , Saccucci Patrizia , Manca Bitti Maria , Rapini Novella , Renzetti Gabriele , Magrini Andrea , Bottini Egidio
Published: March 2018

Fetal genetic adaptation to environment of aging women could result in positive selection of genes that during extrauterine life increases the risk of type 1 diabetes mellitus (T1DM). We have examined the distribution of three genetic polymorphisms (acid phosphatase locus 1 [ACP1], p53 codon 72, and PTPN22) involved in T1DM risk in relation to maternal age at delivery. p53 codon 72 was determined in 281 T1DM children, ACP1 in 207 children, and PTPN22 in 216 children. Controls (blood donors) were 351 for ACP1, 271 for PTPN22, and 730 for p53 codon 72. Genotypes were determined by DNA analysis. The proportions of the three genotypes associated with T1DM are much greater in T1DM children from older mothers than in those from young mothers and in controls. The data support the hypothesis that advanced maternal age favors a positive selection of genes more adapted to the uterine environment of older women: these genes predispose to T1DM during extrauterine life.
Sport und Bewegung mit und nach Krebs – wer profitiert, was ist gesichert?
Authors: Steindorf Karen , Schmidt Martina , Zimmer Philipp
Published: March 2018

A growing number of literature reports positive effects of physical activity and exercise. These effects concern prevention, mortality and progress of cancer. Furthermore they show a reduction of disease- and treatment-specific side effects, which implies a better patients’ quality of life. Evidence shows a decreased mortality risk in patients with physically active cancer of colon, breast, ovaries and prostate. Activity recommendations for patients with cancer do not differ from those for healthy persons. However, a decrease in physical activity can be observed in many cancer patients after diagnosis, and this fact concludes to a reduced physical capacity – although just physical capacity helps to overcome the burden of medical treatment and to recover. In fact, tailored exercise programs can counteract a decrease in physical capacity successfully. Further they reduce side effects such as fatigue, incontinence and lymphedema. Moreover, first studies report a positive influence on: chemotherapy-induced polyneuropathies, cancer-related cognitive impairments, bone health and sleep. Finally, an enormous number of investigations showed that exercise interventions can improve psychosocial factors (e. g. mood and self-esteem). Except for very few conditions, such as extremely impaired blood cell counts and days when cardio- or nephrotoxic drugs are given, physical activity should be recommended. Especially during medical treatment, physicians and therapists are prompted to interact closely in order to prevent general activity prohibitions. Physical activity and exercise programs represent a unique and low-cost chance for cancer patients to influence the course of their own disease positively. More effort is necessary to improve professional activity offers for cancer patients and survivors and to specify activity recommendations.