bluuebunny/crossref_metadata_2025 huggingface dataset:
Contribution of Open Access Databases to Intensive Care Medicine Research: Scoping Review
Authors: Kallout Julien , Lamer Antoine , Grosjean Julien , Kerdelhué Gaétan , Bouzillé Guillaume , Clavier Thomas , Popoff Benjamin
Published: August 2024

Background

Intensive care units (ICUs) handle the most critical patients with a high risk of mortality. Due to those conditions, close monitoring is necessary and therefore, a large volume of data is collected. Collaborative ventures have enabled the emergence of large open access databases, leading to numerous publications in the field.

Objective

The aim of this scoping review is to identify the characteristics of studies using open access intensive care databases and to describe the contribution of these studies to intensive care research.

Methods

The research was conducted using 3 databases (PubMed–MEDLINE, Embase, and Web of Science) from the inception of each database to August 1, 2022. We included original articles based on 4 open databases of patients admitted to ICUs: Amsterdam University Medical Centers Database, eICU Collaborative Research Database, High time resolution ICU dataset, Medical Information Mart for Intensive Care (II to IV). A double-blinded screening for eligibility was performed, first on the title and abstract and subsequently on the full-text articles. Characteristics relating to publication journals, study design, and statistical analyses were extracted and analyzed.

Results

We observed a consistent increase in the number of publications from these databases since 2016. The Medical Information Mart for Intensive Care databases were the most frequently used. The highest contributions came from China and the United States, with 689 (52.7%) and 370 (28.3%) publications respectively. The median impact factor of publications was 3.8 (IQR 2.8-5.8). Topics related to cardiovascular and infectious diseases were predominant, accounting for 333 (25.5%) and 324 (24.8%) articles, respectively. Logistic regression emerged as the most commonly used statistical model for both inference and prediction questions, featuring in 396 (55.5%) and 281 (47.5%) studies, respectively. A majority of the inference studies yielded statistically significant results (84.0%). In prediction studies, area under the curve was the most frequent performance measure, with a median value of 0.840 (IQR 0.780-0.890).

Conclusions

The abundance of scientific outputs resulting from these databases, coupled with the diversity of topics addressed, highlight the importance of these databases as valuable resources for clinical research. This suggests their potential impact on clinical practice within intensive care settings. However, the quality and clinical relevance of these studies remains highly heterogeneous, with a majority of articles being published in low–impact factor journals.
Randomized crossover trial of exergame or physical education sessions benefit subsequent inhibitory control in children with autism spectrum disorder (Preprint)
Authors: Miranda Juliana Macedo , Browne Rodrigo Alberto Vieira , Silva Weslley Quirino Alves da , Santos João Paulo Rodrigues dos , Campbell Carmen Silvia Grubert , Ramos Isabela Almeida
Published: August 2024

BACKGROUND

Autism Spectrum Disorder (ASD) is characterized by persistent impairments in reciprocal social communication and social interaction and restricted and repetitive patterns of behavior, interest or activities; as well as three levels of support for each domain: level 1, requiring support; level 2, requiring substantial support; and level 3, requiring very substantial support.

OBJECTIVE

This study investigated the acute effects of Exergames (EX) and Physical Education (PE) on inhibitory control in children with Autism Spectrum Disorder (ASD).

METHODS

First, they underwent anthropometric assessment, the KTK and Raven’s tests, and familiarization with the cognitive task. They were then given two 20-minute sessions in random order: 1) Physical education session 153.8 bpm (95% CI 139.4, 168.0); exergames session 129.0 bpm (95% CI 121.8, 135.6). To assess inhibitory control, after 5 minutes of recovery, all participants completed a Flanker Task version and responded to the stimulus located in the central target in the middle of four identical congruent (fish facing the same direction) or incongruent (opposite direction) flanker stimuli, for a total of 108 trials.

RESULTS

The ANOVA indicated a difference in incongruent reaction time between the sessions, with a better result in the EX session 849 (95% CI 642, 1057) than in the PE session 938 (95% CI 684, 1191). These results indicate that just one 20-minute session of Exergames was effective in improving inhibitory control in children with ASD.

CONCLUSIONS

Thus, a short period of this session during school can benefit inhibitory control, improving the cognitive capacity of children with ASD and thus contributing to be.

CLINICALTRIAL

This study was registered in the Brazilian Registry of Clinical Trials - ReBEC under the number RBR-5r9xzbq.
Development and Evaluation of a Pharmaceutical Care Pathway for Managing Cancer Pain at Home with Implanted Intrathecal Drug Delivery Systems (IDDS) (Preprint)
Authors: Ju Hua , Shi Lei , Chu Lei , Jiang Weiwei
Published: August 2024

BACKGROUND

Intrathecal infusion therapy, internationally recognized as the best treatment for intractable pain. However, owing to the high risk and uncertainty of intraspinal drug trials, clinical trials of intraspinal drug administration are strictly controlled, which may lead to the occurrence of "off-label" intraspinal drug use in current analgesic therapy. Ensuring the analgesic efficacy and safety of these drugs requires further exploration by pharmacists and clinicians.

OBJECTIVE

Utilizing a mobile information cancer pain management platform, this study aims to establish a pharmaceutical manage pathway for patients managing cancer pain at home with an Intrathecal Drug Delivery System (IDDS) and to assess its clinical effect.

METHODS

A retrospective analysis was conducted on 10 cancer patients with an IDDS implanted without pharmaceutical care (control group) and 10 patients with pharmaceutical care (intervention group). The monitoring period spanned from the first day of admission to 1 week post-discharge. A comparative analysis was performed on pain control, medication compliance, quality of life, and the incidence of adverse reactions between the two groups.

RESULTS

The 24h minimum and 24h average pain scores were significantly lower in the intervention group 1 day after surgery (P<0.05), although there was no significant improvement in reducing DN4 score, improving pain relief rate, medication compliance, appetite and quality of life self-score in the intervention group. One week after discharge, the bodily pain (BP) score in the SF-36 scale of the intervention group significantly increased (P<0.05). One week after discharge, there was no significant difference in the incidence of adverse reactions between the two groups (2=3.28, P>0.05).

CONCLUSIONS

Implementation of a pharmaceutical care pathway based on a mobile information cancer pain management platform effectively reduced postoperative pain scores in home cancer patients with IDDS implantation. It also enhances medication compliance and end-stage quality of life, demonstrating its potential for widespread application and further promotion.
Purifikasi dan Karakterisasi Imunoglobulin Yolk (IgY) terhadap Jembrana dari Telur Ayam sebagai Dasar Pengembangan Imunisasi Pasif
Authors: Kusuma Firdaus Lingga , Wibowo Michael Hariyadi , Wahyuni AETH
Published: August 2024

AbstrakPenyakit Jembrana adalah penyakit yang menyerang Sapi Bali (Bos javanicus) dengan penularan dan kematian yang tinggi. Penyakit ini disebabkan oleh  Jembrana Disease Virus (JDV) dari famili retroviridae. Pengendalian penyakit Jembrana di Indonesia menggunakan vaksin inaktif yang dibuat dari jaringan limfa sapi terinfeksi JDV sehingga produksinya sangat terbatas. Immunisasi pasif menggunakan antibodi terbukti mampu memberikan perlindungan terhadap berbagai infeksi. Ayam merupakan penghasil antibodi immunoglobulin yolk yang sangat baik. Tujuan penelitian ini adalah melakukan purifikasi dan karakterisasi IgY terhadap Jembrana untuk pengembangan imunisasi pasif. Sebanyak 15 ekor ayam white leghorn umur 24 minggu dibagi menjadi 3 kelompok. Kelompok 1 disuntik dengan 1ml vaksin Jembrana, kelompok 2 disuntik dengan seed virus Jembrana, dan kelompok ke 3 adalah kontrol. Penyuntikan antigen Jembrana dilakukan dua kali dengan interval dua minggu. Telur mulai dikoleksi setelah satu minggu penyuntikan antigen pertama sampai minggu ke lima. Uji antibodi Jembrana dilakukan dengan metode Agarose Gel Precipitaion Test (AGPT). Purifikasi IgY dilakukan dengan pengendapan NaCl, sedangkan untuk melihat karakter IgY Jembrana menggunakan SDS PAGE. Pengendapan NaCl mampu menghasilkan IgY dengan mudah dan biaya yang murah. Pengujian AGPT menunjukkan bahwa IgY muncul pada kelompok ayam yang disuntik dengan vaksin Jembrana, dan tidak muncul pada kelompok yang disuntik dengan seed Jembrana. Pengujian SDS PAGE menunjukkan adanya pita protein dengan berat molekul 67 kDa yang merupakan rantai berat, 46 kDa yang merupakan fragmen Fab, dan 24 kDa yang merupakan rantai ringan.
Survei Infeksi Salmonella spp. pada Pasien Anjing dan Kucing di Klinik/Rumah Sakit Hewan Daerah Istimewa Yogyakarta
Authors: Kajang Elphan Augusta , Nugroho Widagdo Sri , Haryanto Aris
Published: August 2024

Salmonellosis is an infectious disease that is zoonotic and includes food borne disease. Salmonella spp. can also be found in pets so that it can be a source of transmission of Salmonellosis to humans. The purpose of this study was to determine the infection level of Salmonella spp. in dogs and cats in clinics/animal hospitals in the Special Region of Yogyakarta. A total of 250 rectal swabs from 83 dogs and 167 cats were taken in this study. Isolation and identification of Salmonella spp. using Xylose Lysine Deoxycholate (XLD), Triple Sugar Iron Agar (TSIA), and Lysine Iron Agar (LIA) media. The isolates were confirmed by Polymerase Chain Reaction (PCR)using a primer Forward primer (5'- GCT AAG TAT GAC ATT CCG GT -3') and reverse (5'- CCA AAG ACT ATC TGC GGA AT -3') eith targeting the STM2773 (IroB) gene. Information on the patient's medical history was obtained based on the anamnesis and questionnaire to the animal owner. Data analysis was descriptive statistics. A total of 32 isolates of Salmomella spp. obtained through conventional methods and as many as 30 samples (12%) confirmed Salmonella spp. using PCR. A total of 11 (13.25%) of 83 dogs and 19 (11.27%) of 167 cats were identified as positive for Salmonella spp. The results of this study indicated that 12% of pet animals in the Special Region of Yogyakarta were infected with Salmonella spp.
Corporate Tax Planning and Accounting Information Disclosure Optimization Strategies
Authors: Xu Yue
Published: August 2024

This paper explores the relationship between corporate tax planning and the optimization strategies of accounting information disclosure, as well as their significance. The article first analyzes the basic concepts of tax planning and accounting information disclosure and their critical roles in corporate financial management. It then discusses common issues and challenges faced by companies in the practical implementation of tax planning and accounting information disclosure, particularly the conflicts and contradictions between the two. Three optimization strategies are proposed: strengthening compliance management in tax planning, enhancing the transparency and completeness of accounting information disclosure, and balancing the relationship between tax planning and information disclosure. By adopting these strategies, companies can improve financial efficiency and market competitiveness within the bounds of legality and compliance, ensuring long-term sustainable development.
An Analysis on the Omnibus Law and Its Challenges in Indonesia: The Perspectives of the Constitutional and the Islamic Law
Authors: Dwiono Sugeng , Ja’far A. Kumedi , Haryadi Slamet
Published: August 2024

The Omnibus Law, which encompasses the Constitutional Law and the Islamic Law, has been the subject of intense dispute since its inception. The controversy has occurred from the inception to the promulgation of the design process within larger communities. Multiple issues emerged from the outset when the administration introduced the proposal for an Omnibus Law in the Indonesian People's Consultative Assembly of the Republic of Indonesia (DPR RI) to its enactment. This study uses normative legal methodologies, which are examined through the lens of the constitutional law theory and the Islamic law. The study determined that the Omnibus Law is a legislative tool commonly employed by countries that follow a common law legal system. However, it was subsequently embraced by nations that follow a civil law framework, such as Indonesia. The Omnibus Law was enacted to ensure the efficient and effective execution of laws, particularly in the area of copyright regulations, in order to prevent any duplication or overlap. Consequently, public perceives the law as lacking ambition and instead favoring the concerns of the community, particularly in relation to employee compensation, employment agreements, and the practice of subcontracting. Based on the constitutional law, this state policy is deemed conditionally unlawful, despite the ongoing application of these legal standards by the executive and parliamentary parties. Within the framework of Islamic jurisprudence, it can be regarded as a component of siyasah syar'iyah or governmental strategy that aligns with the principles of maqāṣid al-sharī'ah, particularly hifdz al-mal, which involves preserving economic stability and promoting halal certification. However, this article contends that the judgment of the Constitutional Court to deem it unlawful is contingent. It advocates for a modification of the copyright law pertaining to creative works, with the aim of ensuring broader adherence to legal regulations.
‘Urf and Its Role in The Development of Fiqh: Comparative Study of Famliy Law Between Egypt and Indonesia
Authors: Fauzi Fauzi
Published: August 2024

This research discusses the dynamics of changes in Islamic family law which is strongly influenced by ‘urf as a dynamic and elastic enrichment. The research question is how is the absorption of ‘urf in Egypt and Indonesia in fiqh, what are the rules for its application and contextualization in the development of Fiqh in Indonesia. Methodologically, this type of research is qualitative with documentation, interviews and observation as technical data collection. The data will be analyzed using the ushul fiqh and Sociological approaches. The results of the research are first, the absorption of ‘urf in Egypt and Indonesia is very strong, especially in the field of Islamic Family Law. In determining the dowry, each region has different customs and considerations, both in Indonesia and Egypt. The difference is in terms of joint assets, the wife in Egyptian 'urf is guaranteed to have assets from three sources; grants, gifts from parents and husbands. Meanwhile in Indonesia, joint assets are considered based on their contribution to the family business after marriage, which varies greatly according to prevailing customs. This difference is considered absorbing 'urf in Fiqh as one of the interpreters of nass are in the form of; ‘urf is dependent, dynamic, accommodates values and norms, contributes to the development of Fiqh and fulfills the elements of maqasid sharia. As a finding, in the Contextualization in the Development of Fiqh, ‘urfcontributes to tajdid (renewal) which places more emphasis on mutaghayyirat of the family law. There is no change in Fiqh without a change in ‘urf.
Shifting Inheritance Patterns in the Minangkabau Tribe in Negeri Sembilan, Malaysia
Authors: Ismail Ismail , Nofiardi Nofiardi
Published: August 2024

In the Minang Urang Darek Luhak Nan Tigo and Urang Rantau Negeri Sembilan Malaysia communities, inheritance is passed down to nieces based on matrilineal practices. They hold a significant role in the tradition, following the sumandocustom, and the offspring belong to their mother's tribe. This study seeks to ascertain whether the practice of inheriting heirlooms in the Minang Urang Darek Luhak Nan Tigo and Urang Rantau Negeri Sembilan Malaysia communities is still in accordance with traditional customs or if it has started to deviate from prior norms. This study employed an anthropological methodology, utilizing in-depth interviews. The findings suggest that the father has taken on the position of an expert and protector, while the mother's involvement is limited to customary events. In contrast to the residents of Negeri Sembilan who continue to reside in the village, there are some who have relocated outside of Negeri Sembilan. The inhabitants of Negeri Sembilan who reside in their native region continue to firmly uphold traditional customs, whilst those that relocate outside of Negeri Sembilan have resettled in their paternal hometowns. The inheritance of ancestral property has altered in accordance with the changing role of the mother. In the past, it was customary for ancestral property to be inherited by nieces. However, there has been a shift in this practice, with some individuals now choosing to pass down their ancestral land to their own children. As a result, many ancestral lands in Negeri Sembilan have been left abandoned as people seek livelihoods in new locations.
Status of Children Born Out of Wedlock: A Study of Constitutional Court Decision and Its Relevance to the View of Ibnu Taimiyah
Authors: Ali Bukhari , Wulandari Nur , Erianti Nahara
Published: August 2024

The Constitutional Court Decision No. 46/PUU-VIII/2010 has introduced a new paradigm in the civil and family law systems. However, this decision has faced significant controversy among Muslims, who constitute the majority religious group in Indonesia. The majority of ulema (Muslim scholars) maintain that children born from zina (fornication) cannot be attributed to their biological fathers. In contrast, Ibn Taimiyah, a renowned Islamic scholar, has proposed the concept of istilhaq, which allows for the attribution of children born from zina to their fathers. This study aims to address three research questions: 1) What is the content of the Constitutional Court Decision No. 46/PUU-VIII/2010? 2) What is Ibn Taimiyah’s opinion on children born out of wedlock? 3) What is the relevance of the Constitutional Court decision to Ibn Taimiyah’s opinion? The study employed a juridical-theoretical method, utilizing both legal and Islamic perspectives. The findings reveal that the majority of ulema hold the view that children born out of wedlock are only attributed to their mothers. Ibn Taimiyah, on the other hand, argues that they can be attributed to their biological fathers through the concept of istilhaq (acknowledgment) and qiyafah (facial resemblance). The Constitutional Court decision does not provide a definitive clarification on the status of children born out of wedlock. Consequently, both children born from underhand marriages and from zina become the responsibility of the biological fathers if their paternity can be established through DNA testing. The relevance between the Constitutional Court decision and Ibn Taimiyah’s opinion lies in their shared recognition of the possibility of establishing nasab (lineage) without solely considering the circumstances of the child’s birth. This recognition can be achieved through DNA testing in the present era and through acknowledgment and facial resemblance assessments in Ibn Taimiyah’s time.
The World War I in the materials of Habib Zaini
Authors: Gabdrafikova Liliya Ramilevna
Published: August 2024

This article is a study of the military experiences of World War I participant Habib Zaini (1890–1967). He fought on the Western Front as part of the 3rd Army and was an active public figure. He worked as a teacher at the Galia madrasah in Ufa before military mobilization. In the 1960s, H. Zaini wrote memoirs, which also include episodes about the war. His life at the Front was the period from August to October 1917. The author comes to the conclusion that H.Zaini’s materials reveal a different picture of the everyday life of a Tatar soldier, different from the traditional intersectional prism of Tatar soldiers. In preparing this article, the author used personal sources (autobiography, memoirs), as well as office materials from the 3rd Army and publications from the newspaper "Voice of the Third Army".
Fot citation: Gabdrafikova L.R. The World War I in the materials of Habib Zaini. From History and Culture of Peoples of the Middle Volga Region. 2024, vol.14, no.1, pp.135–144. https://doi.org/10.22378/2410-0765.2024-14-1.135-144 (In Russian)
Müller cells harboring exosomal lncRNA OGRU modulates microglia polarization in diabetic retinopathy via serving as miRNA sponges
Authors: Fu ShuHua , Sun WenJing , Liu Lu , Xiao JiPing , Xiong Jian , Hu YaoYun , Zhou QianQian , Yin XiaoLong
Published: August 2024

Abstract

Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus which is associated with visual loss and blindness worldwide. However, the effective treatments for both early- and late-stage DR remains lacking. A streptozotocin (STZ)-induced diabetic mice model and high glucose (HG)-treated Müller cell model were established. M1/M2 microglia polarization was assessed by immunofluorescence (IF) staining and flow cytometry. Expression of lncRNA OGRU, cytokines and other key molecules were detected by qRT-PCR or western blot. ELISA assay was employed to monitor cytokine secretion. Müller cell-derived exosomes were isolated and characterized by nanopartical tracking analysis (NTA), western blot and transmission electron microscopy (TEM), and exosome uptake assay was used to monitor the intercellular transport of exosomes. Associations among lncRNA-miRNA-mRNA networks were validated by RNA pull-down and RNA immunoprecipitation (RIP) and dual luciferase assays. Increased M1 polarization but decreased M2 polarization of retinal microglia were observed in DR mice. HG-treated Müller cell-derived exosomes transported OGRU into microglia and promoted microglia polarization toward M1 phenotype. Mechanistically, OGRU served as a competing endogenous RNA (ceRNA) for miR-320-3p, miR-221-3p and miR-574-5p to regulate AR, PFKFB3 and GLUT1 expression in microglia, respectively. Loss of miR-320-3p/miR-221-3p/miR-574-5p or reinforced AR/PFKFB3/GLUT1 abrogated OGRU silencing-mediated microglia polarization in vitro. In vivo studies further showed that OGRU/miR-320-3p/AR, OGRU/miR-221-3p/PFKFB3 and OGRU/miR-574-5p/GLUT1 axes regulated microglia polarization in DR mice. Collectively, Müller cells-derived exosomal OGRU regulated microglia polarization in DR via modulating OGRU/miR-320-3p/AR, OGRU/miR-221-3p/PFKFB3 and OGRU/miR-574-5p/GLUT1 axes.

Keywords: OGRU, exosome, Müller cells, microglia polarization, diabetic retinopathy

Article highlights

l Retinal microglia shifted from M2 toward M1 phenotype in DR mice.

l High glucose-treated Müller cell-derived exosomal OGRU promoted microglia polarization toward M1 phenotype.

l OGRU served as a ceRNA for miR-320-3p, miR-221-3p and miR-574-5p to regulate AR/PFKFB3/GLUT1 expression in microglia.

l OGRU takes essential actions on microglia polarization to be involved in DR progression.
Katı Oksit Yakıt Pillerinin Hücre Gerilimini Minimize Etmek İçin Limited-Memory Broyden-Fletcher-Goldfarb-Shanno ve İmparator Penguen Algoritmasının Kullanılması
Authors: Tuna Ramiz İlker , Ayata Faruk , Seyyarer Ebubekir
Published: August 2024

Optimizasyon yöntemleri çeşitli endüstriyel, bilimsel ve mühendislik uygulamalarında, en verimli planlama stratejisi belirlemek, bir finansal portföyün en iyi dağılımını belirlemek, bir lojistik ağın en verimli şekilde tasarlanması veya bir yapay zekâ modelinin en iyi performansını elde etmek için yaygın olarak kullanılmaktadır. Bu çalışmada ise katı oksit yakıt pillerinin hücre gerilimini minimuma indirerek pillerin performansını arttırmak ve enerji verimliliğini iyileştirmek amaçlanmaktadır. Bu kapsamda L-BFGS-B algoritması ve İmparator Penguen algoritması ile yapılan optimizasyon çalışmalarında Faraday sabiti, Gaz sabiti, Aktivasyon polarizasyonu katsayısı, Ters akım yoğunluğu, Elektrot kalınlığı girdi değerler sabitlenerek sıcaklık (T), oksijen basıncı (p(O2)), hidrojen basıncı (p(H2)) ve su buharı basıncı (p(H2O))’nın minimum gerilim için değerleri hesaplanmaktadır. İki optimizasyon yöntemi için de optimum sıcaklık değeri 1000 K, optimum oksijen basıncı değeri 1.0, optimum hidrojen basıncı değeri 0.000001 ve optimum su buharı basıncı değeri de 0.000001 olarak hesaplanmaktadır. İki optimizasyon yönteminde de minimum hücre gerilimi 0.6486 olarak hesaplanmış ancak L-BFGS-B algoritması sonuca 6 iterasyon ve 0.0046 saniye de ulaşmış; İmparator Penguen algoritması ise 44 iterasyon ve 0,01 saniye de ulaşmıştır. Analiz sonuçlarına göre iki yöntemin de hücre gerilim değerleri aynı olmasına rağmen iterasyon ve süre bakımından L-BFGS-B algoritmasının daha başarılı olduğu görülmektedir.
Deniz Kirliliğinin Görünmeyen Tehlikesi: Gemi Kinistin Sandığı Tıkanıklığı Üzerine Bir Risk Analizi
Authors: Ceylan Bulut Ozan
Published: August 2024

Doğal çevre tahribatının etkileri, son yıllarda dünya denizleri üzerinde ciddi şekilde hissedilmektedir. Çalışmalar, gerek plastik gibi insan kaynaklı kirleticilerin gerekse istilacı türler gibi deniz canlılarının artık denizlerimizde yoğun olarak bulunduğunu göstermektedir. Diğer bir yandan gemilerin kritik bir unsuru olan soğutma suyu sistemleri, gemi kinistin sandıklarından emilen deniz suyu ile hayat bulmaktadır. Ancak, deniz kirliliği kaynaklı kinistin tıkanıklığı, geminin ana ve yardımcı makinelerini çalışamaz duruma getirerek, gemiyi manevra kabiliyetinden mahrum bırakmaktadır. Ana makine gücünü ve dolayısıyla manevra yeteneğini kaybeden gemi ise çarpma, çatışma, karaya oturma, yangın ve patlama gibi felaketlerle yüzleşme riski taşımaktadır. Bu çalışma, deniz kirliliğinin görünmeyen tehlikesi olan kinistin sandığı tıkanıklığı üzerine bir risk analizi yürütmüştür. Çalışmada hem Klasik hem de Bulanık Hata Türü ve Etkileri Analizi (HTEA) yöntemleri kullanılarak, hata türlerine ilişkin riskler Risk Öncelik Sayısı (RÖS) ve Bulanık RÖS (BRÖS) puanlarıyla sayısal olarak hesaplanmıştır. Klasik HTEA bulgularına göre, en riskli 3 hata türü, HT006 - Ana Makine Yüksek Yağlama Yağı Sıcaklığı (143.520), HT007 - Ana Makine Yüksek Ceket Suyu Sıcaklığı (111.720), HT014 - Yangın Pompası Düşük Çıkış Basıncı ve Debisi (100.590) olarak tespit edilmiştir. Bulanık HTEA sonuçlarında ise en riskli 3 hata türü HT006 - Ana Makine Yüksek Yağlama Yağı Sıcaklığı (5.58), HT014 - Yangın Pompası Düşük Çıkış Basıncı ve Debisi (5.51) ve HT013 – Kazan Yetersiz Buhar Yoğuşma Verimliliği (5.47) olarak ortaya konmuştur. Elde edilen bulgular, deniz kirliliğinin gemi sistemleri üzerindeki etkilerini sayısal olarak ortaya koymaktadır. Bu veriler, gemi adamları, denizcilik şirketleri, denetleme otoriteleri ve gemi inşa sektörü gibi temel denizcilik paydaşlarına, gelecekte oluşabilecek kinistin sandığı tıkanıklığı kaynaklı büyük deniz kazalarını önlemek adına önemli bilgiler sunmaktadır.
Biyolojik Olarak Parçalanabilen İmplant Üretiminde Magnezyum Alaşımlarının Mikro Frezelenmesinin Değerlendirilmesi
Authors: Bilgin Musa , Kiliç Zekai Murat
Published: August 2024

Biyolojik olarak parçalanabilen implantların çıkarılması için ikinci bir ameliyata gerek olmaması iyileşme sürecini hızlandırırken sağlık risklerini, maliyetleri ve yara izlerini azaltmaktadır. Toksik madde bırakmadan çözünebilme kabiliyetleri ve mekanik özellikleri Magnezyum alaşımların önemini daha da artırmaktadır. Mikro cerrahideki gelişmeler ve implant üretimindeki kalite standartları göz önüne alındığında mikro frezeleme optimum üretim yöntemi olmaktadır. Mikro frezeleme ile implatın yüzey modifikasyonu sağlanarak implant başarısı artırılabilmektedir. Fakat mikro işleme makro işleme ile kıyaslandığında boyut etkisi, çapak oluşumu ve takım sapması başlıca sorunlardır. Literatür incelendiğinde magnezyum alaşımlarının mikro frezelemesinin araştırılmasının sınırlı kaldığı görülmektedir. Bu çalışmada magnezyum alaşımlarının implant uygulamalarındaki önemi ve mikro işleme de karşılaşılan sorunlar birlikte değerlendirilmiştir. Bu sayede implant uygulamalarında yüzey optimizasyonu sağlanarak mikro frezeleme uygulamalarında imalat kalitesinin ve verimliğinin artırılması amaçlanmıştır.
Estimating Uniaxial Compressive Strength of Sedimentary Rocks with Leeb hardness Using SVM Regression Analysis and Artificial Neural Networks
Authors: Ekincioğlu Gökhan , Akbay Deniz , Keser Serkan
Published: August 2024

Uniaxial compressive strength (UCS) of rock materials is a rock property that should be determined for the design and stability of structures before underground and aboveground engineering projects. However, it is impossible to determine the properties of rocks such as UCS directly due to the lack of standardized sample preparation, necessary equipment, etc. In this case, the UCS of rocks is estimated by index test methods such as hardness, ultrasound velocity, etc. Determining the hardness of rocks is relatively more practical, fast, and inexpensive than other properties. In this study, the UCS of sedimentary rocks was estimated as a function of Leeb hardness using artificial neural networks (ANN) and SVM regression analysis. With the proposed neural network and SVM regression models, it is aimed to obtain more accurate and faster prediction values. To better train the models created in the study, the number of data was increased by compiling data from the studies in the literature. The UCS values predicted by the models obtained with two different methods and the measured UCS values were statistically compared. It was proved that the models created with ANN and SVM regression can be used reliably in predicting UCS values.
Investigation of Hydrogen Production via Black Water Electrolysis
Authors: Gördesel Yıldız Merve , Yörük Özgü , Uysal Duygu , Doğan Özkan Murat
Published: August 2024

As an alternative to hydrogen production by electrolysis of water, using as raw material waste valorization and organic pollutants in wastewater are crucial issues. In this context, electrolysis of black water, produced as waste in olive oil production and high energy source potential due to the aromatic compounds in its content, was carried out in this study. Parametric studies were carried out by examining the effect of working conditions on hydrogen production. The experiments using a two-chamber electrolysis cell examined the effects of catalytic additive (Fe2+/3+), temperature (26oC-60oC-70oC-80oC), type of electrode (Cu/Cu, Zn/Zn and Pd/Pt) and electrolyte (H2SO4, H3PO4, HCl, C2H2O4 and C2H4O2), membrane and pretreatment applied to the membrane. In the electrolysis of black water with FeSO4 and acidic electrolyte (H2SO4) using a pretreated Nafion XL membrane on the Zn/Zn electrode pair, pure H2 formation at the cathode was determined. Under these conditions, 1.9 mA/cm2 current density was obtained at 1 V potential and room temperature.
Chronic Itch Affects Patients’ Ability to Experience Pleasure: Anhedonia in Itchy Disorders
Authors: Stefaniak Aleksandra , Berek-Zamorska Magdalena , Zeidler Claudia , Ständer Sonja , Szepietowski Jacek C.
Published: August 2024

Anhedonia, the reduced ability to experience pleasure, is a prevalent symptom in various psychiatric disorders, but has not been investigated in dermatological conditions, particularly those characterized by chronic itch. This study aimed to examine the prevalence and clinical correlates of anhedonia in patients with chronic itch. A cross-sectional study was conducted in 137 patients with chronic itch, classified according to the International Forum for the Study of Itch (IFSI) classification. Anhedonia was assessed using the Snaith–Hamilton Pleasure Scale (SHAPS) and Anticipatory and Consummatory Interpersonal Pleasure Scale (ACIPS). Itch severity, quality of life, and psychological distress were assessed using the Visual Analogue Scale (VAS), Verbal Rating Scale (VRS), ItchyQoL, and Hospital Anxiety and Depression Scale (HADS), respectively. The mean SHAPS score was 1.0 ± 1.7 points, and the mean ACIPS total score was 76.9 ± 16.2 points. In the study sample, 13.1% of patients were identified as anhedonic, with a higher prevalence observed in those with severe and very severe itch. Anhedonia was significantly correlated with itch severity (R = 0.2, p=0.02 for 24 h VASmean and SHAPS; R = 0.2, p = 0.01 for 24 h VASmax and SHAPS), anxiety symptoms (R = 0.3, p < 0.001 for SHAPS and HADS-anxiety), depression symptoms (R = 0.4, p < 0.001 for SHAPS and HADS-depression), and impairment in quality of life (R = 0.2, p = 0.014 for SHAPS and ItchyQoL). Anhedonia is a significant and prevalent aspect of psychological distress in patients with chronic itch. Addressing this symptom may not only improve patients’ overall mental health but also enhance the effectiveness of treatments for chronic itch. Future research is needed to elucidate further the mechanisms underlying the relationship between anhedonia and chronic itch and to develop targeted interventions for this population.
Denosumab-induced Acute Generalized Exanthematous Pustulosis
Authors: Marovt Maruška , Marko Pij B.
Published: August 2024

Abstract is missing (Short communication)
Impact of green performance management on pro-environmental behavior
Authors: Saeed Amer , Abbas Haidar
Published: August 2024

Environmental issues such as the phenomenon of global warming, the exhaustion of natural resources, and the escalating levels of air and water pollution have garnered significant scrutiny from governmental bodies, non-governmental organizations (NGOs), corporate entities, and the worldwide populace. The primary objective of our study is to address knowledge deficiencies by posing inquiries regarding the influence of an organization's Green Human Resource Management (GHRM) policies on employees' environmental behavior.
Role of Neuroscience and Artificial Intelligence in Biophilic Architectural Design Based on the Principle of Symbiosis
Authors: Adityo Adityo
Published: August 2024

Biophilic architecture aims to create an environment that enhances connectivity between humans and nature to improve physical, mental, and emotional well-being. This review analyses 25 recent scientific journals on the application of neuroscience and artificial intelligence (AI) to optimise biophilic architectural design based on the principle of symbiosis. Results show that neuroscience provides valuable insights into human psychophysiological responses to various biophilic elements, while AI enables complex data processing, predictive modelling, and real-time design adaptation. The collaboration of neuroscience and AI can help produce a more effective, responsive to human needs, and sustainable biophilic environment. On the other hand, flexibility is demonstrated by the breadth of the architectural design process phases that can be reached through this collaboration. However, methodological and ethical challenges must be addressed to ensure responsible application.
Evaluation of Natural Light in EcoHouse Bandung
Authors: Sutanty Prisca Bicawasti Budi , Stefanus Christian Diyaneswara
Published: August 2024

The availability of natural lighting is significant to the quality of life in a residential setting. A residence that is conducive to health and comfort requires adequate natural sunlight, which can eliminate viruses and mould indoors and improve the health of its occupants. Furthermore, the strategic incorporation of natural lighting can also lead to a reduction in energy expenditure. This research aims to evaluate the natural lighting in the EcoHouse Bandung, designed by SHAU Architecture and Urbanism, to ascertain its effectiveness and identify areas requiring improvement. The methodology employed entails the utilisation of simulations conducted with the Autodesk Ecotect Analysis 2011, encompassing the assessment of Shadow Range, Solar Access Analysis, and Lighting Analysis. The analysis results demonstrate that the EcoHouse Bandung has responded effectively regarding orientation and building envelope utilisation. However, some areas require specific adjustments due to insufficient or excessive light intensity. The analysis indicates the necessity for optimisation in several areas, including workspaces, living rooms, dining rooms, and bathrooms on the first floor. This research identifies three main principles for eco-house design: firstly, primary lighting should not disturb neighbours or cause harm to occupants; secondly, facade materials and technologies should be selected based on each façade's specific requirements; and thirdly, corridors should be considered as primary barriers in reducing excess heat and light. These findings are anticipated to optimise existing conditions and achieve ideal standards that support environmental sustainability and occupant comfort.
Efektivitas Metode Index Card Match Dalam Meningkatkan Hasil Belajar Pendidikan Agama Islam Siswa SMA Negeri 1 Hiliran Gumanti
Authors: Ialam Rezatul , Rahman Rini
Published: August 2024

This study is driven by the fact that teachers often employ monotonous teaching strategies; when there is no variation in the methods used, learning becomes dull and lowers student learning outcomes. Instead of engaging in learning, students typically engage in other activities. The purpose of this study is to determine whether the Index Card Match method at SMA N 1 Hiliran Gumanti improves student learning results. This study examines the impact of the index card match method on student learning outcomes using quantitative methods and a quasi-experimental design. Purposive sampling was used to choose 51 pupils from the population of 79 students. SPSS 26 was used to analyse the data. The study's findings demonstrate the value of the Index Card Match approach in improving class X (Phase E) students at SMA Negeri 1 Hiliran Gumanti's learning objectives. Evaluate efficacy with the N-Gain score. According to the research findings, the Index Card Match Method is excellent at enhancing student learning outcomes because, in the paired sample t test, t count = 8.018 and significance = 0.001 indicate that H0 is rejected. The results of the Independent Sample t test showed that H0 was rejected when t count = 2.515 > t table = 2.00958 and significance = 0.015 < 0.05. When the N-Gain score was tested, the medium category's average N-Gain was found to be 0.4373, within the interval 0.2 < d < 0.8.  The study concludes that for Islamic Religious Education class X Phase E SMA N 1 Hiliran Gumanti, the Index Card Match approach improves learning results more than the lecture method.
INFLUENCE OF PERIPHERAL STRESS-LIMITING SYSTEM DISORDERS ON THE COURSE OF PREGNANCY IN WOMEN WITH PREECLAMPSIA
Authors: Kosilova Svitlana
Published: August 2024

The aim of research. To study the eﬀ ect of peripheral stress- limiting system disorders on the course of pregnancy in women with preeclampsia (PE).Material and methods. A clinical and statistical analysis of the course of pregnancy in 34 patients with PE (main group) was performed. Of these, 20 had moderate PE (group I) and 14 had severe PE (group II). The control group consisted of 20 healthy women. Indicators of lipid peroxidation (LPO) and antioxidant system (AOS) protection were studied at 24-26 and 34-36 weeks of pregnancy.Research results. In pregnant women with PE, disturbances in the lipid peroxidation system of the AOS were revealed. Against the background of excessive activation of lipid peroxidation in women of group I, there is an AOS deﬁ ciency, as evidenced by the absence of an increase in glutathione and glutathione peroxidase at 34-36 weeks (p>0.05). In group II, glutathione peroxidase did not increase (p>0.05). Glutathione activity did not increase at 24-26 weeks (p>0.05), and at 34-36 weeks it signiﬁ cantly decreased, indicating the depletion of the AOS defense. This had a negative impact on the functional state of the body of pregnant women, contributed to the progression of the severity of PE and a signiﬁ cant increase in the incidence of complications during pregnancy.Conclusions. An increase in the level of ROS products in the mother’s blood precedes the clinical manifestation of oxidative stress and correlates with the severity of PE. Pregnant women with moderate PE have antioxidant deﬁ ciency and stress of compensatory and adaptive mechanisms of the mother’s body. In pregnant women with severe PE, there is a depletion of the body’s antioxidant defense and a possible failure of compensatory and adaptive mechanisms. The frequency of complications of pregnancy in women with severe PE is signiﬁ cantly higher than in women with moderate PE. Levels of reduced glutathione and glutathione peroxidase activity can be considered as biochemical markers of impaired compensatory and adaptive mechanisms of maternal defense.
STATISTICAL ANALYSIS OF MAPS OF ELLIPTICITY OF POLARIZATION OF DIGITAL MICROSCOPIC IMAGES OF BLOOD FACES AND DIFFERENTIAL DIAGNOSIS OF THYROID GLAND PATHOLOGY
Authors: Bilookyi Oleksandr , Ushenko Oleksandr , Bilookyi Viacheslav , Kurek Yelena , Soltys Iryna , Sklyarchuk Valery
Published: August 2024

The main characteristics and achievements of Mueller- matrix polarimetry in the diagnosis of pathological changes in the optical anisotropy of the microstructure of biological tissues and ﬂ uids are widely presented in scientiﬁ c works. At the same time, the diagnostic capabilities of Mueller- matrix polarimetry are limited by signiﬁ cant depolarization of light scattering in bulk biological objects.The aim of the study. Conducting a comparative analysis of the eﬀ ectiveness of methods of statistical processing of polarization ellipticity maps of digital microscopic images of supramolecular protein networks of polycrystalline blood facies with the aim of determining new objective criteria (markers) of digital laser histological diﬀ erential diagnosis of thyroid pathology.
Material and methods. Four groups of donors and sick patients were studied: 1. Control group 1 – healthy donors (51 patients). 2. Research group 2 – patients with nodular goiter (51 patients). 3. Research group 3 – patients with autoimmune thyroiditis (51 patients). 4. Research group 4 – patients with papillary cancer (51 patients). A comparative analysis of the eﬀ ectiveness of methods of statistical processing of polarization ellipticity maps of digital microscopic images of  supramolecular protein networks of polycrystalline blood facies was carried out in order to determine new objective criteria (markers) for digital laser histological diﬀ erential diagnosis of thyroid pathology Research results. A comprehensive statistical analysis of polarization ellipticity maps of experimental blood samples of donors and patients with nodular goiter, autoimmune thyroiditis and papillary cancer was carried out. Objective statistical markers for the diﬀ erential diagnosis of thyroid pathology have been determined. The results of information analysis of integrated ellipticity maps demonstrated a good diagnostic capacity of diagnosis (~87.3 % – 88.3 %) and a satisfactory level (~78.4 % – 81.4 %) of diﬀ erentiation of thyroid gland pathology.Conclusions. 1. Experimental results of polarization mapping of polarization ellipticity maps of digital microscopic images of blood facies of donors and patients with nodular goiter, autoimmune thyroiditis, and papillary cancer are presented and analyzed within the framework of a complex statistical approach. 2. The most optimal statistical markers of the mapping method of polarization ellipticity maps of digital microscopic images of blood facies were found to be the most optimal, and a good diagnostic capacity of diagnosis (~87.3 % – 88.3 %) and a satisfactory level (~78.4 % – 81.4 %) of diﬀ erentiation of thyroid pathology were established.
Расчет напряженности электрического поля на малых расстояниях между зарядом и источником электрического поля на основании макроскопической математической модели
Authors: Хоруженко Вадим
Published: August 2024

Моя работа представляет собой макроскопическое обобщение теорий Калуцы-Клейна для квантовых систем, касающееся существования дополнительного пятого измерения в нашем пространстве. Это позволило Калуце объединить описание гравитации и электромагнетизма в рамках единой математической структуры. Позже Оскар Клейн добавил важный элемент к теории Калуцы, предложив, что пятое измерение компактно свернуто в очень маленький круг с радиусом порядка планковской длины. Из-за своей малости это измерение остается невидимым на обычных масштабах. Кроме того, я опирался на идеи, предложенные Фейнманом, который предложил использовать понятие плотности энергии в пространстве для описания электромагнитных взаимодействий на квантовом уровне в рамках Квантовой Электродинамики (КЭД). Эта теория помогает объяснить, как на коротких расстояниях происходит экранирование и ренормализации заряда из-за взаимодействий с виртуальными частицами в вакууме.
Political Identity in the Digital Age: Analysis of the Impact of Social Media on the Formation of Youth Beliefs and Values
Authors:   Kazan State Energy University, Kochetkova Natalia P.
Published: August 2024

The article presents a new approach to understanding the formation of political identity among youth in the digital age by integrating sociometric methods with the analysis of public opinion polarization. The relevance of this work is underscored by the social and governmental importance of studying the processes related to the formation of political identity. The novelty of the research lies in the innovative approach to applying sociometry, which allows for a more detailed examination of the influence of social media on the formation of political beliefs and values. It highlights the dual role of social media as a platform for diverse viewpoints and as a potential tool for manipulative content dissemination. By focusing on the demographic characteristics of youth and utilizing sociometric data, the author illuminates the complex processes of political socialization in the context of digital media, emphasizing their dual nature as both educational tools and mechanisms for information manipulation. The findings and conclusions emphasize the importance of critical engagement with digital information and advocate for regulatory measures to protect against misinformation.
Predestination and Indeterminacy of the Future in Western and Eastern Cultures
Authors:   Kalmyk State University named after B.B. Gorodovikov, Spiridonova Lyudmila Yu.
Published: August 2024

This article investigates the perception of the future in Western and Eastern cultures through the lens of the binary opposition “predestination and indeterminacy”. The research methodology draws upon historical-cultural, cultural-philosophical, and comparative analysis of ideas about the future. Within the context of Western culture, the ideas concerning the predestination of human fate by philosophers from various epochs, ranging from Antiquity to modern times, are explored. Plato asserted the predestination of human future by a divine plan, whereas Aristotle denied any predestination and insisted on an open future. The Middle Ages scrutinized the question of predestination and free will within Christian doctrine, particularly through the teachings of Augustine. Particular attention is also given to the ideas of David Hume, Friedrich Nietzsche, Georg Simmel, Jean-Paul Sartre, and other thinkers who challenged the notion of divine predestination and advocated for human freedom of choice as the basis of his existence. The interpretation of future perception in Eastern culture is examined through examples from Chinese culture, Indian culture, and Buddhist philosophy. The author analyzes the concept of “ming” (fate) in Chinese philosophy, karma in Indian culture, and the causal relationship of suffering among all living beings in Buddhism. In conclusion, it is argued that Eastern culture differs from Western culture in its more holistic approach to this issue: the future may be predestined, yet humans still possess the ability to influence their destiny and alter the lot that has fallen to them.