bluuebunny/crossref_metadata_2025 huggingface dataset:
Antinociceptive and cytotoxic potential of ethanolic extract of Delonix regia (Leaves)
Authors: Parul Rozina , Alam Md. Jahir , Rana Md. Sohel
Published: May 2018

This study investigated the antinociceptive and cytotoxic effects of alcoholic extract of Delonix regia Leaves in rodents. Antinociceptive activities were done using paw licking and writhing tests. The extract was used at dose of 200 and 400 mg/kg per orally as compared to Standard drug Diclofenac-Na 100 mg/kg bw in Swiss albino mice of body weight 25-30 g. The cytotoxic activity was determined by the Brine Shrimp lethality bioassay. The alcoholic extract showed very highly significant effect in formalin test (p 0.01). Also had the highest analgesia (p 0.001) in the acetic acid-induced writhing model as well. The extract possessed a good in vitro cytotoxic activity (LC50=4.06 μg/ml). The results suggested that Delonix regia Leaves extract has a suitable antinociceptive effect as well as cytotoxic potential.
A overview: non-steroidal anti-inflammatory drugs and mechanisms
Authors: Patrekar Prasad V. , Mali Sachin S. , Kashid Komal , More Snehal , Mali Savita S. , Dongare Sujata D.
Published: May 2018

The inflammatory response represents a generalized response to infection or tissue damage and is designed to remove cellular debris, to localize invading organisms and arrest the spread of infection. NSAIDS are metabolized primarily in the liver. They vary in their half-lives and bioavailability. Given the multitude of available NSAIDs, the variability of their half-lives allows for different dosing regimens. The fluid in the inflamed area is known as inflammatory exudates, commonly called as pus. These exudates contain dead cells and debris in addition to body fluids. The inflammatory response is characterized by the following symptoms: Reddening of the localized area, swelling, pain and elevated temperature. Reddening results from capillary dialation that allows more blood to flow to the damaged tissue. Elevated temperature results from capillary dialation which permits increased blood flow through these vessels, with associated high metabolic activities of neutrophils and macrophages. The release of histamine from mast cells during antigen antibody reactions is well known, as is its involvement in the inflammatory response to skin injury. The present review focused on list and precautions of NSAID with its typed and classification, Analgesic activity study, histamine.
An analytical study on panchavalkala choorna - a poly herbal compound in the management of psoriasis
Authors: Dharmarajan Prasanth , . Harisha , Paul Raiby , Thakar Anup B. , Jani Switu
Published: May 2018

Background: Panchavalkala Choorna is a poly herbal compound made from the barks of five major drugs from the Ficus family. It is widely quoted as an effective remedy in various skin disorders explained under the wide spectrum of Kushta (skin disorders), mentioned in Ayurvedic classics. However, till date no published data is available on the analytical profile of this compound formulation. The present study was aimed to standardize and develop the pharmacognostical and phytochemical profile of Panchavalkala Choorna. The compund was prepared as per classical methods and analytical findings were systematically recorded. The samples were subjected to organoleptic analysis, physicochemical analysis and High performance Thin Layer Chromatography (HPTLC) examination by optimizing the solvent systems. Pharmacognostical profile of Panchavalkala Choorna was established. Loss on drying, Specific gravity, Viscosity and Refractive index, Iodine value, Acid value and Saponification value of Panchavalkala Choorna were found within prescribed limits. HPTLC fingerprinting profile of ST revealed 6 spots at 254 nm and 4 spots at 366 nm. Two spots were merging in both the long and short UV, showing common characters in both the wavelengths.
Preliminary Pharmacological Screening of Ethanolic Extract of Aristoochia indica on Nephrolithiasis Rat
Authors: Kumbhar B P , Burli S C , Mali S S , Dongare S D , Patrekar P V
Published: May 2018

The effect of ethanolic extract of Aristolochia indica was studied on experimentally induced
nepharolithatic and urolithuasis in rats. Oxalate urolithiasis was produced by the addition of
0.75% ethylene glycol in the diet for a period for 30 days. Ethylene glycol treatment resulted
in a significant increase in the levels of calcium and oxalate. Treatment of ethanolic extract of
Aristolochia indica 100mg/kg body weight for 30 days revealed a dose –related effect in the
reduction of lithogenic substances, following glycolic acid induced urolithiasis. Simultaneous
oral treatment with at a dose of ethanolic extract of Aristolochia indica 100mg/kg for 30 days
significantly reversed the ethylene glycol induced nepharolithiasis and urolithiasis.
Presumably by preventing the urinary supersaturation of lithogenic substances. Especially of
oxalate and calcium. These observation indicate that ethanolic extract of Aristolochia indica
can play an important role in the prevention of disorders associated with kidney stone
formation.
Variants of Tribulus species – a scientific study through DNA RAPD – molecular characterization
Authors: Patil Bhavesh , Patel Bhupesh , R. Harisha C. , Parmar Neha , Save Ashwini
Published: May 2018

Gokshura a well-known drug in Ayurveda which is extensively used in many disease conditions like dysuria, asthma, diabetes, cough, oedema, cardiac disorders etc. Tribulus terrestris (Family – Zygophyllaceae) is an official source of Gokshura as per API. Five species of genus Tribulus are found throughout India with a slight morphological difference. In this study, three different species of Tribulus genus from different regions were subjected for molecular characterization by RAPD method. Analysis showed that three different samples gave clearly similar banding pattern with each of the random primers used and 80% similarity between the three samples were observed when the results were subjected to band scoring and analysis with clustering. Even through the micromorpholgical observations showed differentiating characters in mature carpels and intrastaminal glands of the selected species.
Establishment of social clubs as a potential tool to educate adolescents living in urban field practice area of Shri BM Patil Medical college, Bijapur
Authors: Gudadinni M. R. , J. Shashank K. , Soragavi Vijaya
Published: May 2018

Introduction: Globally half of the new HIV/AIDS cases are among the age group of 15 to 24 years and the greatest hope for changing the course of epidemic lies with the same agegroup. Within this age group, adolescents are more vulnerable to HIV infection as they do not have access to appropriate information or awareness of the dangers of high risk behavior. Objectives: Utilization and Impact of Social Clubs on imparting Knowledge to the Adolescents regarding HIV/ AIDS. Methodology: The study was conducted from Dec 2012 to Nov 2013. Assuming a 30 per cent prevalence of knowledge on HIV/AIDS, 95 per cent confidence interval and 15 per cent allowable error and 10 % dropout rate the calculated sample size was 438 adolescents Results: Out of 438 enrolled adolescents in the social club, 64 per cent participated in vocational training courses (62% girls and 38% boys) and also they participated in recreational activities and AIDS education sessions. The remaining (36%) participated only in recreational activities.88 per cent of adolescents attended more than 75 per cent of educational sessions held while 10 Per cent attended only 50 to 75 per cent of AIDS awareness sessions. Conclusion: The social clubs seem to have potentials to improve HIV/AIDS awareness among adolescents to adopt a healthy lifestyle and can be utilized to address various issues related to adolescents.
Characterization of Bioactive compound isolated from Myrothecium spp. with UV, FTIR and HPLC Analysis
Authors: Pervez1 Mohammad Rizwan , Musaddiq Mohammed , Thakare Prashant V. , Kumar Ashutosh
Published: May 2018

Development of new drugs, especially in area of infectious diseases, represents today one of the most
important research. Fungal isolates are receiving increasing attention by natural product chemists due to
their diverse and structurally unprecedented compounds making them interesting candidates for drug
discovery. In fact, need for novel, safe and more efficient antibiotics is a key challenge to the
pharmaceutical industry today, moreover, increase in opportunistic infections in the immune
compromised host has influenced this demand. Nowadays, evaluating morphological and biochemical
differences as well as studying fungal genetic diversity via molecular indicators seem to be the most
common method for screening this genus. In this research we evaluate the potential of bioactive
compound, production and characterize the UV and FTIR spectroscopy and HPLC (High performance
liquid chromatography) analysis pattern of isolated Myrothecium spp. MRP001. Process development
for high level production of bioactive compound was applied using OFAT method. Then, following the
extraction of secondary metabolite, the UV and FTIR spectroscopy analysis was carried out for
characterization of the various extracts. Considering the coordinate analysis of UV and FTIR
spectroscopy pattern, the isolate MRP001 with substantial antimicrobial activity exhibited absorption at
3411 cm-1 which is indicator of hydroxyl groups, absorption at 2856 and 2915 cm-1 indicating
hydrocarbon chassis, and absorption at 1649 cm-1 indicating a double bond of polygenic compound.
These results highlight the importance of Myrothecium isolates in antibiotic production. HPLC
confirmed the production when compared with standards
Pharmacognostical and Pharmacochemical Parameters of Tablet Sutashekhara Rasa – Without Gold
Authors: Mata Shweta P. , Vaghela D. B. , Dhiman K. S. , Harisha C. R. , Shukla V. J.
Published: May 2018

Tablet Sutashekhara Rasa (TSR) is an Ayurvedic, herbo-metal formulation prescribed widely for several conditions such as Acid peptic disorders, Pain in abdomen, Haemorrhage, Mental disorders etc. On analysis of pharmcodynamics of this compound it is basically Pitta corrective drug. Ardhavabhedaka (Migraine) is also one of the clinical morbidity which is manifested by vitiated Pitta/Rakta along with Vata. The available treatment in modern medicine is use of NSAIDs, Beta-blockers etc. with only temporary relief. TSR being a Pitta corrective is used in a clinical study with new indication in Ardhavabhedaka (Migraine). Till date there is no data available regarding evaluation ofTSR. Present study an attempt to develop newer approaches for the quality control and standardization of TSR. The samples were subjected to organoleptic, physicochemical analysis and Chromatographic (HPTLC) examination by optimizing the solvent systems. The phrmacognostical study of ingredients of TSR shows the presence of Sceleriform vessel, Lignified stone cells, Bottle necked shapedstone cells etc. Pharmaceutical analysis showed that the Average weight of tablet 276mg, Average hardness of tablet 2.05 Kg/cm2 , Loss on drying 4.7904% w/w, pH value 7 and High Performance Thin Layer Chromatography at 254nm and 366nm resulted into 6 spots.
Investigation of antiparkinsonian effect of Aloe vera on haloperidol induced experimental animal model
Authors: Bagewadi Harish G. , A.K. Afzal Khan
Published: May 2018

Background: Aloe vera (Family: Liliaceae) has been used for the treatment of diabetes, skin disorders and as an anti-inflammatory agent. There is increased concern about the side effects of conventional medicine in the treatment of Parkinson’s disease (PD). As A.vera has found to have antioxidative property, it may be a safer alternative. Methods: Parkinson’s disease was induced by administering haloperidol (1 mg/kg i.p. daily x 1 week).The mice of either sex were divided into 06 groups (n =12). 1 st day group mice were given distilled water (orally), 2nd group were administered haloperidol (20 mg/kg i.p.).The 3rd, 4th and 5th groups were administered A.vera (100, 200, and 400 mg/kg/day, orally) respectively, along with haloperidol. Group 6- received Levodopa (30mg/kg, i.p,) along with haloperidol. To evaluate anti-Parkinson effect, hanging wire test, tardive dyskinesia test and hole board test were performed on the1st day and 8th day. One way ANOVA was used to detect statistical significance followed by post-hoc Tukey test. Results: A.vera (200 and 400 mg/kg, p.o.) was found to increase the hanging time significantly (p 0.001) in hanging wire test and significantly decreased (p 0.001) the Vacuous Chewing Movements (VCMS) in tardive dyskinesia test as compared to haloperidol group. A.vera (200 and 400 mg/kg, p.o.) was found to significantly increase (p 0.001) the number of dips and no. of line crossings in hole board test when compared to haloperidol group. Conclusion: The results of the present study conclusively showed that A.vera has beneficial effect in haloperidol induced experimental model of Parkinson’s disease.
Comparative studies of Volatile Components of the essential Oil of leaves and flowers of Catharanthus
roseus growing in Bangladesh by GC-MS analysis
Authors: Aziz Shahin , Saha Koushik , Sultana Nasim , Khan Mala , Nada Katrun , Afroze Mirola
Published: May 2018

Catharanthus roseus is an important medicinal plant commonly known as Madagasker
periwinkle. Traditionally different parts of its used in the treatment of various diseases (e.g.
diabetes, menstrual regulators, hypertension, cancer and antigalactogogue etc.) in number of
countries. The essential oil of leaves and flowers of Catharanthus roseus growing in
Bangladesh were investigated by gas chromatography coupled to mass spectrophotometery
(GC-MS) to determined the chemical composition of the volatile fraction and identify their
chemotypes. Quantification of active principles through analytical tools is essential for
establishing the authenticity and credibility. Extraction by steam distillation and analysis with
GC-MS have been shown to be valuable tools for the identification of the constituents of
essential oil of leaves and flowers of Catharanthus roseus and can provide a useful guide
about the variation of the components. The main objective of the present study was focused
on identification and quantification of chemical constituents present in the essential oil of
leaves and flowers of Catharanthus roseus by GC-MS methods. 24 compounds consisting
(95.99%) of the total for the case of leaves were identified. And total 10 compounds
consisting (98.20%) of the total for the case of flowers of Catharanthus roseus were
identified by GC-MS analysis in Bangladesh. For the case of leaves the identified components
were : terpenoids (75.41%) , alkanes (6.0%) , aldehydes (5.5%), fatty acids (3.6 %),
ketones (3.2%), alcohol (2.28%) respectively. For the case of flowers the identified
components fatty acid esters (98.20) % respectively.
Diabetes: a risk factor for mortality from brain stroke
Authors: Joshi Vandana , Kumar Arun , Kothiyal Preeti
Published: May 2018

Diabetes mellitus (DM), is a most common problem around the world and contributes to the development of different types of complications due to various pathological changes like change in thickening of capillary basement membrane, increase in vessel wall matrix and cellular proliferation. Diabetes mellitus represents a strong independent risk factor for stroke. The current review is an attempt to summarize the possible mechanisms that has been associated with increased risk of stroke due to diabetes mellitus.
Morphometric Approach towards Growth Performance of Mahseer (Tor tor) in River Narmada Near Hoshangabad (M.P)
Authors: Badkur R , Parashar A
Published: May 2018

During present study total 58 specimens of Mahseer (Tor tor) from River Narmada were studied for morphometric and meristic characteristics. Interrelationship among the morphometric and meristic characteristics were observed. The morphometric characters showed a proportional positive growth with the increasing length of the fish. The regression coefficient (b) of variable parameters (Y) on total length (X) showed that growth rate with respect to total length was maximum in case of weight (b = 3.113) and lowest in mouth tip to operculum top (b = 0.957).The correlation coefficient (r) was found positive for different morphometric parameters with respect of total length. In case of morphometric parameters proportional positive growth with increasing length of the fish was recorded during the present study
Pharmacognostical, Phytochemical and Pharmacological Overview: Cissus quadrangularis Linn.
Authors: Shukla Rahul , Pathak Anup , Kambuja S. , Sachan Sandeep , Mishra Ashutosh , Kumar Sankul
Published: May 2018

Cissus quadrangularis (Linn) has been used by the common man in India, and neighboring countries, Pakistan, Sri Lanka, Malaysia for promotion of fracture healing and well known as “Hadjod”. It is also known as Vitis quadrangularis Wall. belongs to family Vitaceae. It is a common perennial climber, which is distributed throughout India, particularly in tropical regions. It requires warm tropical climate and propagated by stem cuttings. The plant is prescribed in the ancient Ayurvedic literature as a general tonic and analgesic, with specific bone fracture healing properties. The plant is believed to be useful in helminthiasis, anorexia, dyspepsia, colic, flatulence, skin diseases, leprosy, hemorrhage, epilepsy, convulsion, haemoptysis, tumors, chronic ulcers, swellings. The scrutiny of the present overview revealed pharmacognostical, phytochemical and some notable pharmacological activities of the plant such as Anti-osteoporotic activity, antioxidant, free radical scavenging, antimicrobial, antibacterial, bone healing, anti ulcer, analgesic and anti inflammatory, diuretic, Anabolic and Androgenic activity and toxicity studies.
Antimicrobial analysis of Triphala and comparison with its individual constituents
Authors: Mahajan Darshna , Jain Sapna
Published: May 2018

Triphala, a well known ayurvedic formulation is used against number of ailments since ancient times. It consists of Emblica officinalis, Terminalia chebula and Terminalia bellerica in equal proportion. Triphala as a whole and its three individual constituents show specific antimicrobial activity against certain bacteria and fungi. Antimicrobial activity of aqueous extract of triphala and its constituents was studied against P.aeruginasa, E.coli , B.subtilis, K. pneumoniae and S.aureus by cup-plate method. Triphala was found strongly bactericidal against P. aeruginosa with 1.8 cm of inhibitory zone. This was on account of T. chebula which showed 1.2 cm of inhibitory zone against the same pathogen, followed by E. coli and other two Gram positive bacteria. T. bellerica however showed maximum inhibitory activity against B.subtilis by showing 2.2 cm of inhibitory zone. It was confirmed that antimicrobial activity against Gram negative bacteria is due to T. chebula and E. officinalis while antimicrobial activity against Gram positive bacteria is on account of T. bellerica. Antifungal activity of Triphala and its constituents was studied against two pathogenic fungi viz. Aspergillus niger and Candida albicans by the same method. Triphala was found more efficient against A. niger, this was on account of T. bellerica which showed nearly 2 cm zone of inhibition. T. bellerica and Triphala showed more than 2 cm inhibitory zone against C. albicans. Inhibitory zone of Emblica officinalis was observed to be of 1.5-2 cm against both the fungi, whereas T. chebula did not show inhibitory activity against C. albicans but showed nearly 1 cm of inhibitory zone against A. niger. This confirms that the antifungal activity of Triphala is primarily due to T. bellerica and E. offiicinalis.
Pharmacognostic studies of the stem bark of Chloroxylon swietenia DC
Authors: Deb Nilip Kanti , Singh Anoop , Rathore Devendra Singh , Dash Gouri Kumar , Deb Jhuma
Published: May 2018

Chloroxylon swietenia DC. (Family: Rutaceae) is an important traditional medicinal plant used in the treatment of various ailments like fungal infection of skin, rheumatism, common cold, cough, ophthalmic infection and cataract, wounds and as an astringent. However, detailed scientific information is not available to identify the plant material, in order to ascertain its quality and purity. In this paper, we report the pharmacognostic evaluation of the bark for the purpose of its identification and differentiation from related species. The macroscopy, microscopy, physicochemical parameters such as moisture content, ash values, extractive values, fluorescence analysis and preliminary phytochemical analysis of the bark were investigated. Transverse section of the bark shows presence of cork, cortex, medullary rays, and stone cells. Presence of cork, stone cells, phloem fibres and parenchyma cells which were also observed in the powdered sample of the bark. The result of preliminary phytochemical screening indicated presence of alkaloids, steroids, carbohydrates, proteins, phenolic compounds, tannins flavonoids and triterpenoids. The present study will be useful for its identification prior to carrying out further research work. The findings of this study will facilitate pharmacognostic standardization of the plant material and aid in the preparation of a herbal monograph for the species.
Study of lipid profile in hypertensive subjects
Authors: K Anuradha , Mathur Ranjana , Sood Sadhna
Published: May 2018

Aim : The present study was designed to investigate lipid profile in hypertensive subjects. Material and Method : The present study was carried out on 25 healthy controls and 25 hypertensive subjects of either sex and of varying age groups attending the Out Patient Department of Medicine, Dr. S.N. Medical College and Associated group of hospitals, Jodhpur. Results: The results obtained in this study showed that the results of TG ,Total cholesterol ,HDL-c ,VLDL-c ,LDL-c were highly significant in patients compared with control subjects .Conclusion: The present study indicates an increased TG ,Total cholesterol ,VLDL-c ,LDL-c and decreased HDL-c values in hypertensive subjects, which is due to many factors like obesity ,age etc.
Occupational stress in female academic staff working in private and public universities
Authors: Amin Maha Abdul Moniem Mohammed El , A Purna Singh
Published: May 2018

The present study was aimed to compare occupational stress between female academic staff working in private and public universities. The sampling frame for the study comprised 1523 full-time female academic staff working at both public and private universities at Khartoum State. Gumaa Said Yousif (2004) was used to measure occupational stress. There is no significant difference in occupational stress between female academic staff who works in private or public university. There is a significant difference between female academic staff working in public and private universities. It has been concluded that female academic staff working in private universities are vulnerable to burnout in the emotional exhaustion dimension.
MANİSA İLÇELERİ SANAYİ GÖSTERGELERİNİN TEMATİK HARİTALANMASI
Authors: AKPINAR Rasim , KESKİN Rıdvan
Published: May 2018

Manisa ve
çevresindeki iller, sosyoekonomik gelişmişlik açısından üst sıralarda yer
almaktadır. Kalkınma Bakanlığı tarafından 2003 ve 2011 yıllarında birbirinden
farklı değişkenlerle hazırlanan “İllerin Sosyo-Ekonomik Gelişmişlik Endeksi
Sıralaması” çalışmaları incelendiğinde Manisa’nın 25. sıradan 23. sıraya
yükselmiş olması dikkat çeken bir gelişmedir. İldeki 6 ilçede üretim aşamasına
geçmiş 4, toplamda ise 7 adet organize sanayi bölgesi bulunmaktadır. İlde
üretim aşamasına geçmiş organize sanayi bölgesi bulunan ilçeler Manisa Merkez
(Yunusemre), Akhisar, Salihli ve Turgutlu’dur. İlde imalat sektöründe üretimin
üçte birinden fazlası elektrikli teçhizat ve gıda sektörlerinden elde
edilmektedir. İlde yoğunlaşmanın yüksek olduğu sektörlerden elektrikli teçhizat
imalatı %19’luk pay ile imalat sanayi üretim değerine en çok katkı sağlayan
sektör konumundadır. Bu çalışmanın amacı sektörel çeşitliliğiyle birlikte Manisa
sanayisinin mekânsal dağılımını haritalandırılmış bir biçimde ortaya koymaktır.

Bu çalışma; Bilim,
Sanayi ve Teknoloji Bakanlığı’nın sanayi sicil kanununa göre sanayi
işletmelerinin vermek zorunluluğu olan sanayi sicil belgelerinden istifade
etmiştir. Bu veri tabanına göre; 2012-2016 dönemi için Manisa’da ilçeler
bazında sanayi işletmelerinin sektörleri, faaliyet adları, ciroları,
çalıştırdıkları mühendis sayısı, üretim değerleri yer almaktadır. Bu çalışmada;
Manisa sanayisinin mekânsal yoğunlaşmaları mekânsal analiz yöntemi kullanılmak
suretiyle haritalandırılarak Manisa sanayisinin sektörel farklılaşmaları da ortaya
konulmuş olacaktır.
Some effects of the doping with alpha - Al_2O_3 nanoparticles in the transport properties of Bi_1.65 Pb_0.35 Sr_2Ca_2 Cu_3O_y ceramic superconductors
Authors: Hernández Wolpez Manuel Alfredo
Published: May 2018

We present a preliminary study on the effects of alpha - Al_2O_3 nanoparticles (NPs) in the transport properties of Bi_1.65 Pb_0.35 Sr_2Ca_2 Cu_3O_y ((Bi,Pb)-2223) ceramic samples. The (Bi,Pb)-2223 samples were synthesized by the solid state reaction method and alpha - Al_2O_3 NPs, with concentrations ranging from 0.1 to 0.8 wt. percent (% wt.), were added before the last heat treatment. All samples were characterized by means of X-rays diraction patterns, and temperature and magnetic eld dependence of the electrical resistivity, rho(T;Ba). From the experimental (T;Ba) data we extracted the critical temperature dependence of the % wt. of alpha - Al_2O_3 NPs, and by using the Arrheniusplot the eective pinning energy has been also determined. The results indicate that mostly of the transport properties are optimized for the sample B03.
Increase of Curie temperature with La doping in the double perovskite Sr2-LayFeMoO6 within an electronic correlation approach
Authors: Estrada Chávez Francisco , Guzmán E. J. , Aguilar Bertha , Navarro Oracio , Avignon Michel
Published: May 2018

The double perovskite compound Sr2FeMoO6 has a half-metallic ferromagnetic character and ahigh Curie temperature (420 K). Fe-Mo usually present some degree of disorder in either Fe orMo ions, it is therefore fundamental to understand the role of electronic and structural parameterscontrolling the half-metallic character together with a Curie temperature as high as possible. We replaceddivalent Sr2+ by trivalent La3+ ions in Sr2FeMoO6 system to observe the Curie temperaturebehavior. We present an electronic approach using the Green's functions and the renormalizationperturbation expansion method, with localized Fe-spins and conduction Mo-electrons interactingwith the local spins via a double-exchange-type mechanism. We also include the electronic correlationsamong the conduction electrons within a mean-eld approximation. Our results showthe density of states and the Curie temperature behavior when La concentration increases for theSr2y-yLayFeMoO6 system
The motion of a relativistic charged particle in a homogenous electromagnetic field in De-Sitter space
Authors: Demirkol Ridvan Cem , Körpinar Talat
Published: May 2018

We discuss the geometric characterization of the trajectoryof a moving charged particle, for the case of a homogeneous electromagneticeld, in De-Sitter space when the motion is governed by the Lorentz equa-tion. We employ totally relativistic approach during the discussion and itis based on a systematic use of the four-dimensional Frenet-Serret formulae,which is adapted to the De-Sitter space to determine the worldline geometryof the electromagnetic eld acting on the particle in De-Sitter space, and ofthe Faraday antisymmetric tensor properties.
The Relationship between Intuitive Action Choices and Moral Reasoning on Animal Ethics Issues in Students of Veterinary Medicine and Other Relevant Professions
Authors: Verrinder Joy M. , Phillips Clive J.C.
Published: May 2018

With growing understanding of animals' capabilities, and public and organizational pressures to improve animal welfare, moral action by veterinarians and other relevant professionals to address animal issues is increasingly important. Little is known about how their action choices relate to their moral reasoning on animal ethics issues. A moral judgment measure, the VetDIT, with three animal and three non-animal scenarios, was used to investigate the action choices of 619 students in five animal- and two non-animal-related professional programs in one Australian university, and how these related to their moral reasoning based on Personal Interest (PI), Maintaining Norms (MN), or Universal Principles (UP) schemas. Action choices showed significant relationships to PI, MN, and UP questions, and these varied across program groups. Having a previous degree or more experience with farm animals had a negative relationship, and experience with horses or companion animals a positive relationship, with intuitive action choices favoring life and bodily integrity of animals. This study helps to explain the complex relationship between intuitive moral action choices and moral reasoning on animal ethics issues. As a useful research and educational tool for understanding this relationship, the VetDIT can enhance ethical decision making.
Teaching Tip: Development of Veterinary Anesthesia Simulations for Pre-Clinical Training: Design, Implementation, and Evaluation Based on Student Perspectives
Authors: Jones Jana L. , Rinehart Jim , Spiegel Jacqueline Jordan , Englar Ryane E. , Sidaway Brian K. , Rowles Joie
Published: May 2018

Anesthesia simulations have been used in pre-clinical medical training for decades to help learners gain confidence and expertise in an operating room environment without danger to a live patient. The authors describe a veterinary anesthesia simulation environment (VASE) with anesthesia scenarios developed to provide a re-creation of a veterinarian's task environment while performing anesthesia. The VASE uses advanced computer technology with simulator inputs provided from standard monitoring equipment in common use during veterinary anesthesia and a commercial canine training mannequin that allows intubation, ventilation, and venous access. The simulation outputs are determined by a script that outlines routine anesthesia scenarios and describes the consequences of students' hands-on actions and interventions during preestablished anesthetic tasks and critical incidents. Patients' monitored physiologic parameters may be changed according to predetermined learner events and students' interventions to provide immediate learner feedback and clinical realism. A total of 96 students from the pre-clinical anesthesia course participated in the simulations and the pre- and post-simulation surveys evaluating students' perspectives. Results of the surveys and comparisons of overall categorical cumulative responses in the pre- and post-simulation surveys indicated improvement in learners' perceived preparedness and confidence as a result of the simulated anesthesia experience, with significant improvement in the strongly agree, moderately agree, and agree categories (p<.05 at a 95% CI). These results suggest that anesthesia simulations in the VASE may complement traditional teaching methods through experiential learning and may help foster classroom-to-clinic transference of knowledge and skills without harm to an animal.
Supplier Selection Model of the Lithium-ion Battery using Fuzzy AHP and Analysis of BOCR
Authors: Wardayanti Ari , Zakaria Roni , Sutopo Wahyudi , Louhenapessy Bendjamin Benny ,   Industrial Engineering Department, Faculty of Engineering, Sebelas Maret University, Surakarta, Indonesia,   Industrial Engineering Department, Faculty of Engineering, Sebelas Maret University, Surakarta, Indonesia,   Industrial Engineering Department, Faculty of Engineering, Sebelas Maret University, Surakarta, Indonesia,   National Center for Sustainable Transportation Technology, Indonesia,   Department of National Standardization Agency (BSN), Jakarta, Indonesia
Published: May 2018

Although the demand for the lithium-ion battery for electronic consumers and electric vehicles in Indonesia is high, there is no supplier coming from the local manufacturer. The proper selection of suppliers is required by some lithium-ion battery manufacturers (cells, modules, and packs), and Research and Development (R&D) center of the lithium-ion battery with the consideration not only in benefits and cost but also in opportunities and risks. It is important that experts assist the manufacturers and R&D to procure the lithium-ion (materials and cells), through transparent methods that seek a quantitative model to select the right supplier. The main objective of this study is to propose an analytical approach to select suppliers which incorporate Benefits, Opportunities, Costs and Risks (BOCR) concept that comply with the characteristics of the lithium-ion battery industries. A fuzzy Analytical Hierarchy Process (AHP) model is developed by accommodating the vagueness and inaccuracies of expert elections. The result of this research is development of the model obtained from 2 questionnaires given to the expert. Questionnaire 1 was made for the determination of criteria and sub-criteria, while Questionnaire 2 aims to perform pairwise comparisons of existing criteria and sub-criteria. In the selection of the lithium-ion battery suppliers, there are 11 criteria and 40 sub-criteria which are considered. Those criteria are divided into 4 merits and known for their respective global priorities.
Optimization of Bus Body Frame Structure for Weight Minimizing with Constraint of Natural Frequency using Adaptive Single-Objective Method
Authors: Haryanto Ismoyo , Raharjo Fuad Arief , Kurdi Ojo , Haryadi Gunawan Dwi , Santosa Sigit Puji ,   Department of Mechanical Engineering, Faculty of Engineering, University of Diponegoro, Semarang, Indonesia,   National Center for Sustainable Transportation Technology, Indonesia,   Department of Mechanical Engineering, Faculty of Engineering, University of Diponegoro, Semarang, Indonesia,   Department of Mechanical Engineering, Faculty of Engineering, University of Diponegoro, Semarang, Indonesia,   National Center for Sustainable Transportation Technology, Indonesia,   Department of Mechanical Engineering, Faculty of Engineering, University of Diponegoro, Semarang, Indonesia,   National Center for Sustainable Transportation Technology, Indonesia,   National Center for Sustainable Transportation Technology, Indonesia
Published: May 2018

The objective of this work is to analyze and optimize a bus frame structure using Finite Element Method in dynamic conditions. The bus body geometry was obtained directly from the three-dimensional Computer-Aided Design files. The optimization was conducted to determine the minimum weight of the bus frame structure without violating the specified natural frequency constraints. The design variable is the thickness of the bus body frame. In present study, Adaptive Single Objective method was chosen as an optimizer method. The results show that the structural weight of the bus frame can be reduced about 8% without changing its dynamic characteristic.
Editorial
Authors: Gagnon Jean-Paul , Chou Mark
Published: May 2018

This issue begins with Peter Strandbrink’s argument that “standard liberal
democratic theory should be pressed significantly harder to recognize the
lexical and conceptual fact that civic political and cognitive participation
in mass liberal democracies belong to different theoretical species.” It is
by conflating both of these theoretical species, which Strandbrink sees as
the dominant tendency in contemporary democratic theory, that we inhibit
our ability to critically evaluate “epistocratic theoretical registers.”
Further unsettling is Stranbrink’s view that, once separated from each
other, neither the theories of civic political or cognitive participation
offer much help in dealing with the rise of “alt-facts” or “post-truth” in
liberal democratic societies today.
Epistocracy and Democratic Participation in a Post-Truth World
Authors: Standbrink Peter
Published: May 2018

This article investigates civic-political and cognitive participation
as they play out in democratic theory. Its core purpose is to develop
a conceptual-normative critique of the presupposition in liberal democratic
theory that these logics are mutually reinforcing and complementary. This
misunderstanding of a theoretical ambivalence contributes to inhibiting constructive
assessment of epistocratic*technocratic frameworks of democratic
interpretation and theory. I demonstrate that these logics circulate contrasting
views of democratic power and legitimacy and should be disentangled
to make sense of liberal democratic theoretical and political spaces. This critique
is then fed into a political-epistemological interrogation of post-truth
and alt-facts rhetorical registers in contemporary liberal democratic life, concluding
that neither logic of participation can harbor this unanticipated and
fundamentally nonaligned way of doing liberal democratic democracy.
Online Supplement A
Authors: Gagnon Jean-Paul
Published: May 2018

SUPPLEMENT A

2,234 Descriptions of Democracy:
An Update to Democracy’s
Ontological Pluralism
Ties of Blood
Authors: Farhi Moris
Published: May 2018

Father sprouted from that shoot of David which circumambulated Jerusalem's stones after the Dispersion which recognised Yahweh in all His other names which decked in Ottoman turbans helped raise the Levant as an ark for all races all cultures which shook hands with shepherds and artisans sipped tea with poets musicians and courtesans dressed janissaries and equerries waged war and peace on backgammon boards graced weddings circumcisions christenings funerals everywhere between Damascus and Sarajevo Algiers and Batumi
Identified as the Enemy
Authors: Zimler Richard
Published: May 2018

I would like to describe the nightmare of being a Jew or New Christian during a unique period in Portuguese history, beginning in the year 1492 and ending in 1536 – the era, not coincidentally, that corresponds to the events in a novel of mine that was recently released in Britain, The Last Kabbalist of Lisbon.
Muslim Lands, Christian Heroes, Jewish Voices
Authors: Pomeroy Hillary
Published: May 2018

The Spanish Jews who fled to North Africa from the 1391 pogroms were joined a century later, in 1492, by a larger wave of exiles, the thousands of Jews who had chosen to leave Spain rather than convert to Christianity. These fellow Jews, the megorashim or expelled Jews, had been forbidden to take 'gold and silver or minted coins' out of Spain (Edwards 1994: 52). They did, however, take with them invisible assets: their Spanish language and culture. This Iberian presence in Morocco was further reinforced by the arrival of a third group of Spanish-speaking Jews fleeing the forced conversions imposed by Portugal in 1497.
Paul Celan
Authors: Friedlander Albert
Published: May 2018

The severe mourning period after Shiva – the week following the death of a loved one – is Sh'loshim – thirty days. What shall we do thirty years after the death of one of the greatest Jewish poets of our century? He entered death freely, walking into the Seine and letting the dark waters carry him into the time beyond time; yet he remains one of the great gifts of the past century for us who are aware of the inheritance which is passed on to us by the poets and prophets of our people.
Book Reviews
Authors: Magonet Jonathan , Friedlander Albert H. , Friedlander Evelyn
Published: May 2018

The Art of Public Prayer: Not for Clergy Only (second edition), Lawrence A. Hoffman, Sky-Light Paths Publishing, Woodstock, VT, 1999, 270 pp., $17.95, ISBN 1-893361-06-3

A Heart of Many Rooms: Celebrating the Many Voices within Judaism, David Hartman, Jewish Lights Publishing, Woodstock, VT, 1999, 298 pp, $24.95, ISBN 1-58023-048-2

Moses - The Prince, the Prophet: His Life, Legend and Message for Our Lives, Rabbi Levi Meier, Woodstock, VT, Jewish Lights Publishing, 1998, 224 pp., $23.95, ISBN 1-58023-013-X

Voices from Genesis: Guiding Us Through the Stages of Life, Norman J Cohen, Woodstock, VT, Jewish Lights Publishing, 1998, 179 pp., $21.95, ISBN 1-879045-75-3

These Are the Words: A Vocabulary of Jewish Spiritual Life, Arthur Green, Woodstock, VT, Jewish Lights Publishing, 1999, 304 pp. (hc), $21.95, ISBN 1-58023-024-5

New Voices in Jewish Thought: a collection of essays edited by Keith Harris with a foreword by Jonathan Webber. Volume Two, London, Limmud Publications, 1999, 101 pp., ISBN 0-9532273-2-4

Lebendiges Judentum II - Predichtung und Betrachtnung eines Rabbines 1990-1995, Israel Aaron Ben Yosef, Arbeiten von Ursula Harver und Rahel Rosenzweig, Erhaus gegeben von Erhard Roy Wien, Hartung-Gorre Verlag Konstanz, 1999, 219 pp., DM44. ISBN: 3-89649-382-5
Questions to the Millennium
Authors: Hilton Michael , Scott Ruth , Shamma Abdin Amira
Published: May 2018

The Annual Jewish-Christian-Muslim Student conference, jointly organised by the Leo Baeck College, the Hedwig Dransfeld Haus and the Deutsche Muslim Liga (Bonn), celebrated its twenty-seventh anniversary with a reflection on the theme of the Millennium – or rather the different 'ages' of the three monotheistic religions. The speakers were asked to reflect on where their religions were in terms of their historic development and where they were personally in their own religious lives.
The Left Party and the AfD
Authors: Olsen Jonathan
Published: May 2018

In the 2017 German Federal Election. The Left Party (Die Linke, or
LP) saw its vote share in eastern Germany seriously erode. The main culprit
behind the LP’s losses was the Alternative for Germany (AfD): 430,000 voters
who cast their ballots for the LP in 2013 voted for the AfD in 2017. Why was
this the case? This article suggests that the AfD in 2017 was able to attract
protest voters, largely in eastern Germany, dissatisfied with the state of democracy
and the political establishment in Germany who once voted for the LP.
The LP and AfD have become eastern German populist competitors.
Hyperphosphorylated Truncated Protein Tau Induces Caspase-3 Independent Apoptosis-Like Pathway in the Alzheimer's Disease Cellular Model
Authors: Zilkova Monika , Zilka Norbert , Kovac Andrej , Kovacech Branislav , Skrabana Rostislav , Skrabanova Michaela , Novak Michal
Published: May 2018

Neurofibrillary degeneration and neuronal loss represent key pathological hallmarks of Alzheimer's disease (AD). It has been demonstrated that the decrease of total neuronal numbers correlates with the presence of neurofibrillary degeneration in AD brain. In order to unravel the mechanism leading to the cell death in AD, we developed a stably transfected human neuroblastoma cellular model with doxycycline-regulatable expression of AD truncated tau protein (AT tau, 151-391 4R). Cells expressing the longest tau isoform (Tau 40) were used as a control. We found that more than 80% of the total amount of AT tau and Tau 40 were phosphorylated. Strikingly, both AT tau and Tau 40 reduced the metabolic activity of the cells in a time-dependent manner (p < 0.0001) suggesting that tau overexpression slows down cell proliferation. However, AT tau showed significantly higher toxicity than Tau 40 (p < 0.0001), which indicates that truncation leads to a toxic gain of function. The analysis of the type of the cell death revealed the characteristic features of apoptosis such as cell shrinkage, nuclear, and DNA fragmentation. However, we did not find either the activation of executive caspase (caspase-3) or the caspase cleavage products (PARP and fodrin). These results show that posttranslationally modified truncated tau protein induces caspase-3-independent apoptosis-like programmed cell death, a phenomenon we term tauoptosis.
Lysosomal β-Galactosidase and β-Hexosaminidase Activities Correlate with Clinical Stages of Dementia Associated with Alzheimer's Disease and Type 2 Diabetes Mellitus
Authors: Tiribuzi Roberto , Orlacchio Antonio , Crispoltoni Lucia , Maiotti Mariangela , Zampolini Mauro , De Angeliz Massimiliano , Mecocci Patrizia , Cecchetti Roberta , Bernardi Giorgio , Datti Alessandro , Martino Sabata , Orlacchio Aldo
Published: May 2018

Multiple epidemiological studies have shown that individuals affected by type-2 diabetes mellitus (T2DM) carry a 2-to-5-fold higher risk of developing Alzheimer's disease (AD) when compared to non-diabetic subjects. Thus, biochemical parameters that can be easily and routinely assessed for high-confidence evaluation of diabetic conditions leading to AD (AD-T2DM) are regarded as efficient tools aimed at early diagnosis and, in turn, timely AD treatment. In this regard, the activity of lysosomal glycohydrolases may of use, in light of the implication of these enzymes in early events that underlie AD pathology and an overt correlation, in diabetes, between altered metabolic homeostasis, abnormal glycohydrolase secretion in body fluids, and occurrence of diabetic complications. Based on marked up-regulation previously shown in a peripheral, cell-based model of AD, we selected β-Galactosidase, β-Hexosaminidase, and α-Mannosidase to discriminate T2DM from AD-T2DM subjects. A screen of 109, 114, and 116 patients with T2DM, AD and AD-T2DM, respectively, was performed by testing enzyme activities in both blood plasma and peripheral blood mononuclear cells. Compared to age-matched, healthy controls (n = 122), β-Galactosidase and β-Hexosaminidase activities markedly diverged across the three groups, whereas virtually unchanged values were observed for α-Mannosidase. In particular, plasma β-Galactosidase and β-Hexosaminidase levels were higher in patients with AD-T2DM compared to those with T2DM, suggesting different mechanisms leading to enzyme secretion. Statistical analyses based on ROC curves showed that both β-Galactosidase and β-Hexosaminidase activities, either intracellular or plasma-secreted, may be used to discriminate AD patients from controls and AD-T2DM from T2DM patients.
Independent Component Analysis-Based Classification of Alzheimer's Disease MRI Data
Authors: Yang Wenlu , Lui Ronald L.M. , Gao Jia-Hong , Chan Tony F. , Yau Shing-Tung , Sperling Reisa A. , Huang Xudong
Published: May 2018

There is an unmet medical need to identify neuroimaging biomarkers that allow us to accurately diagnose and monitor Alzheimer's disease (AD) at its very early stages and to assess the response to AD-modifying therapies. To a certain extent, volumetric and functional magnetic resonance imaging (fMRI) studies can detect changes in structure, cerebral blood flow, and blood oxygenation that distinguish AD and mild cognitive impairment (MCI) subjects from healthy control (HC) subjects. However, it has been challenging to use fully automated MRI analytic methods to identify potential AD neuroimaging biomarkers. We have thus proposed a method based on independent component analysis (ICA) for studying potential AD-related MR image features that can be coupled with the use of support vector machine (SVM) for classifying scans into categories of AD, MCI, and HC subjects. The MRI data were selected from the Open Access Series of Imaging Studies (OASIS) and the Alzheimer's Disease Neuroimaging Initiative databases. The experimental results showed that the ICA method coupled with SVM classifier can differentiate AD and MCI patients from HC subjects, although further methodological improvement in the analytic method and inclusion of additional variables may be required for optimal classification.