bluuebunny/crossref_metadata_2025 huggingface dataset:
Data from HPV and p53 Status as Precision Determinants of Head and Neck Cancer Response to DNA-PKcs Inhibition in Combination with Irradiation
Authors: Hayrapetyan Liana , Roth Selina M. , Quintin Aurélie , Hovhannisyan Lusine , Medo Matúš , Riedo Rahel , Ott Julien G. , Albers Joachim , Aebersold Daniel M. , Zimmer Yitzhak , Medová Michaela
Published: February 2025

Abstract
Major risk factors of head and neck squamous cell carcinoma (HNSCC) are tobacco use and human papillomavirus (HPV). HPV E6 oncoprotein leads to p53 degradation, whereas HPV-negative cancers are frequently associated with TP53 mutations. Peposertib is a potent and selective, orally administered small-molecule inhibitor of the catalytic subunit of the DNA-dependent kinase (DNA-PKcs), a key regulator of nonhomologous end joining (NHEJ). NHEJ inhibition along with irradiation (IR)-induced DNA double-strand breaks has the potential to increase antitumor treatment efficacy. In this study, we investigated the responses of a panel of HNSCC models with distinct HPV and p53 status to treatments with IR, DNA-PKcs inhibition, and their combination in vitro and in vivo. IR-induced DNA damage combined with peposertib administration shortly before IR results in decreased cell viability and proliferation and causes DNA repair delay in all studied HNSCC cell lines. However, our data confirm that the actual cell fate upon this treatment is determined by cellular p53 and/or HPV status. Cells lacking functional p53 due to its degradation by HPV or due to a loss-of-function mutation are arrested in the G2/M phase of the cell cycle and eliminated by apoptosis, whereas p53-proficient HNSCC cell lines preferentially undergo senescence. This is also recapitulated in vivo, where HPV+ UD-SCC-2 xenografts display stronger and more durable responses to the combined treatment as compared with p53 wild-type UM-SCC-74A tumors. In conclusion, DNA-PKcs inhibitor peposertib should be further studied as a potential radiosensitizer for HNSCCs, taking into consideration the genetic background and the HPV status of a particular tumor.
Data from Development and Characterization of a Lysosome-Targeting SLC3A2/PD-L1 Bispecific Antibody–Drug Conjugate for Enhanced Antitumor Efficacy in Solid Tumors
Authors: Wang Zeng , Zheng Meijun , Li Mengyao , Lu Huaqing , Liu Nanxi , Chen Yongdong , Yang Nian , Zeng Wanqin , Dong Yijun , Li Jia , Zhu Zhixiong , Yang Chen , Zhang Zongliang , Lu Qizhong , Li Hexian , Zhou Liangxue , Yang Hui , Tong Aiping
Published: February 2025

Abstract
Bispecific antibodies (BsAb) and antibody-drug conjugates (ADC) have shown significant promise in cancer treatment, enhancing drug selectivity and therapeutic efficacy as demonstrated in multiple clinical studies. Bispecific antibody-drug conjugates (BsADC), which combine the targeting capabilities of BsAbs with the cytotoxic potential of ADCs, offer a novel approach to overcoming several challenges associated with ADCs, including limited internalization, off-target toxicity, and drug resistance. In this study, we identified solute carrier family 3 member 2 (SLC3A2) as a highly expressed protein in a variety of solid tumors, making it a promising therapeutic target. We developed a BsAb targeting SLC3A2 and PD-L1 and conjugated it to monomethyl auristatin E (MMAE) to create the SLC3A2/PD-L1 BsADC. The SLC3A2/PD-L1 BsAb effectively blocked PD-1 binding to PD-L1 and activated T cells while also facilitating lysosomal targeting and degradation of poorly internalized PD-L1 antibodies. The SLC3A2/PD-L1 BsADC demonstrated superior antitumor efficacy in PD-L1 low-expressing tumor cells compared with single-target ADCs in both in vitro studies and in multiple xenograft and immunocompetent mouse models. Overall, our engineered SLC3A2/PD-L1 BsADC exhibited enhanced internalization and improved tumor cell targeting, highlighting the potential of lysosome-targeting BsAbs in advancing ADC therapeutic strategies for solid tumors.
Table 1 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Authors: McDonald Elizabeth S. , Pan Tien-Chi , Pant Dhruv K. , Troester Melissa A. , Kossenkov Andrew V. , Mankoff David A. , Mach Robert H. , Chodosh Lewis A.
Published: February 2025

Association of PGRMC1, TK1, LDLR, and TMEM97 with proliferation. Meta-analysis was performed to examine the association among a) PGRMC1, b) TMEM97, c) TK1, and d) LDLR and estimated proliferation rates of tumors
Supplementary Figure S3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Authors: McDonald Elizabeth S. , Pan Tien-Chi , Pant Dhruv K. , Troester Melissa A. , Kossenkov Andrew V. , Mankoff David A. , Mach Robert H. , Chodosh Lewis A.
Published: February 2025

This shows that TK1 is associated with early breast cancer relapse.
Supplemental Table S5 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Authors: McDonald Elizabeth S. , Pan Tien-Chi , Pant Dhruv K. , Troester Melissa A. , Kossenkov Andrew V. , Mankoff David A. , Mach Robert H. , Chodosh Lewis A.
Published: February 2025

This shows the association of our proliferation score with established scores like Oncotype Dx and PAM50.
Figure 3 from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Authors: McDonald Elizabeth S. , Pan Tien-Chi , Pant Dhruv K. , Troester Melissa A. , Kossenkov Andrew V. , Mankoff David A. , Mach Robert H. , Chodosh Lewis A.
Published: February 2025

TMEM97 is associated with early breast cancer relapse in a proliferation-dependent manner. Effect size estimates were aggregated across datasets by meta-analysis to determine the risk of relapse within 5 years. A, TMEM97 is associated with early breast cancer relapse only in ER+ tumors. B, TMEM97 is associated with early breast cancer relapse only in ER+/HER2− tumors. C, Association of TMEM97 with early breast cancer relapse in ER+/HER2− tumors adjusted for proliferation. JRH, John Radcliffe Hospital; RFS, recurrence-free survival.
Data from Ternary Complex Components Responsible for Rapid LDL Internalization as Biomarkers for Breast Cancer Associated with Proliferation and Early Recurrence
Authors: McDonald Elizabeth S. , Pan Tien-Chi , Pant Dhruv K. , Troester Melissa A. , Kossenkov Andrew V. , Mankoff David A. , Mach Robert H. , Chodosh Lewis A.
Published: February 2025

Abstract
The ternary complex of progesterone receptor membrane component 1 (PGRMC1)–sigma-2 receptor/transmembrane protein 97 (σ2R/TMEM97)–low-density lipoprotein receptor (LDLR) has recently been discovered and plays a role in cholesterol transport. This study investigated whether individual components of that complex are prognostic breast cancer biomarkers and have defined expression in established molecular subtypes. A total of 4,463 invasive breast cancers were analyzed as a function of molecular and phenotypic markers, estimates of cellular proliferation, and recurrence-free survival. A gene expression signature–based assay was utilized to estimate cellular proliferation. Cox proportional hazards regression estimated relapse-free survival and multivariate Cox analysis adjusted for the association of proliferation with early relapse. PGRMC1–σ2R/TMEM97–LDLR expression was stratified by immunohistochemical (IHC) and molecular subtype, tumor grade, and size. TMEM97 exhibited the strongest correlation with proliferation, highest in estrogen receptor (ER)–positive disease (r = 0.59, P = 8.1−114). TMEM97 and PGRMC1 were associated with a risk of early recurrence, dependent upon their association with proliferation. The risk of early recurrence was highest with TMEM97 and only seen in ER+/HER2− disease [HR = 1.5; 95% confidence interval (CI) = 1.35–1.67; P = 5.4−14] and ER+ malignancies (HR = 1.49; 95% CI = 1.31–1.68; P = 3.1−10). There was no increased risk of recurrence with TMEM97 expression in ER−/HER2− (HR = 1.05; 95% CI = 0.88–1.25; P = 0.63) or ER− disease (HR = 1.02; 95% CI = 0.89–1.17; P = 0.75). Components of a ternary complex associated with rapid internalization of low-density lipoprotein are biomarkers associated with cellular proliferation and early recurrence, which should help guide studies exploring them in the context of additional markers of aggressive disease. Elucidating the role of PGRMC1, TMEM97, and LDLR in breast cancer will facilitate a mechanistic understanding of how proliferation interplays with cholesterol metabolism in malignant transformation or propagation.
Significance:
This first large-scale analysis of the putative ternary complex responsible for rapid low-density lipoprotein internalization in breast cancer reveals a link between component expression and recurrence, with prognostic implications for identifying patients needing supplemental posttreatment surveillance and/or additional therapeutic approaches.
Efficacy of Electrofulguration for Women with recurrent urinary tract infection on quality of life and sexual function
Authors: Sevinç Cüneyd , Özkaptan Orkunt , Çanakcı Cengiz , Yılmaz Uğur , Çubuk Alkan
Published: February 2025

Introduction
The primary objective of the study was to assess the impact of EF in women with rUTI on quality of life and sexual health.
Methods
This prospective observational clinical study included 152 patients women who underwent EF because of rUTI and were followed for a minimum of 18 months. The SF-12 questionnaire and the Female Sexual Function Index (FSFI) are used to evaluate quality of life and sexual dysfunction. The Patient Global Impression of Improvement (PGI-I) scale was assessed to evaluate subjective cure. Endoscopic success was defined as complete resolution of previous lesions without new lesions seen during cystoscopy Clinical success was defined as no urinary tract infections at the last follow-up; improvement as 1-2 treated infections/year; and failure as ≥3 treated infections/year. Chi-square test, Wilcoxon, and Student's paired t-test were used.

Results
Seventy patients (52.6%) were defined as cured at least a 1-year follow-up. The subjective cure rate was 71.4% (N = 95) according to PGI-I scores. Women had significantly higher average FSFI scores (P=0.001) in the one-year postoperative assessment. Overall, pathological mental health and physical health scores were significantly higher after the intervention (P=0.00). Thirty-one (23.3%) patients improved clinically with <3 infections per year, and 32 (24.1%) patients failed with >3 infections per year. A total of 97 (74.4%) patients had endoscopic resolution postoperative evaluation.
Conclusion
EF resulted in clinical cure and improvement in the large majority of the patients. A significant proportion of the patients demonstrated enhanced sexual function and quality of life.
Dissecting tunica responsibility in arterial stress relaxation:
Smooth muscle need not apply
Authors: Thompson Janice M. , Watts Stephanie W.
Published: February 2025

Introduction: Stress relaxation is considered a property of smooth muscle. Rings of thoracic aorta with/without perivascular adipose tissue (PVAT) stress relax. However, rings of isolated PVAT, containing no organized smooth muscle, also stress relax. We hypothesize that smooth muscle is not necessary in the individual tunicas of the aorta for stress relaxation to occur. Methods: Histochemical staining and isometric contractility were performed on whole or tunicas of the thoracic aorta from the male and female Dahl salt-sensitive (SS) rats on normal diet. Masson Trichrome (MT) and Verhoeff Van Gieson (VVG) staining validated the isolation of the different tunicas.   Stress relaxation was measured after cumulative amounts of passive tension were applied in the presence or absence of extracellular Ca2+, followed by challenge with the a1 adrenergic agonist phenylephrine (PE, 10-5 M).  Results: Stress relaxation occurred in all tunicas at each passive tension regardless of Ca2+. PE-induced contraction was observed in tissues containing smooth muscle (media, whole vessel) but not in the adventitia and aPVAT with Ca2+. No contraction was observed with no Ca2+. Conclusions: All tunicas of the rat thoracic aorta stress relax, doing so without dependence on smooth muscle or Ca2+.  PVAT demonstrated the greatest ability to stress relax.
Cost-effectiveness of silver diamine fluoride depends on caries activity: A decision analytic model
Authors: Tan Sharon Hui Xuan , Wang Yi , Lai Clement Wei Ming , Gao Xiaoli , Wee Hwee Lin , Lai Bien Wen Pui , Hong Catherine Hsu Ling , Hu Shijia
Published: February 2025

Introduction: The study sought to assess the cost-effectiveness of silver diamine fluoride (SDF) relative to sodium fluoride varnish (NaF), and direct restorations placed chairside or under general anaesthesia (GA), accounting for caries activity.
Methods: An analytical decision tree model was developed with clinical data from multiple centres to evaluate the four treatment options among all children aged 1 to 6 years in Singapore (N=231,880) over a 12-month time horizon. Base-case scenarios consisted of children with low- (1 carious tooth) and high- (7 carious teeth) caries activity. Incremental cost-effectiveness ratios (ICER) and net monetary benefits (NMB) were tabulated with the outcomes set to be the control of active caries and avoidance of tooth extractions. Deterministic and probabilistic sensitivity analyses were conducted.
Results: Overall, SDF was less effective than direct restorations placed chairside but was less costly. For children with low-caries activity, the ICER for SDF was $9 per caries-controlled tooth, and $68 per extraction avoided. For children with high-caries activity, the ICERs were $267 and $1 909 respectively. At a willingness-to-pay threshold of $30, the NMB was negative (favours restorations) for caries control in children with low-caries activity and positive (favours SDF) for all other situations. In the low-caries activity group, SDF had a 41.5% probability of being cost-effective for caries control and 49.2% probability of being cost-effective for the avoidance of extraction. The corresponding probabilities for the high-caries activity group were 99.8% and 100%. The NMB of SDF increases proportionally with caries activity, suggesting utilisation of SDF should depend on caries activity. Results were most sensitive to changes in relative cost, and effectiveness of SDF/direct restorations.
Conclusion: SDF was cost-effective in most situations except for caries control in children with low-caries activity. Direct restorations were more effective and should be considered in low-caries activity children.
Patients with chronic migraine present persistent functional disorders in the interictal phase: observational case-control study
Authors: Dantas Maria Ivone Oliveira , Feitosa Amanda Santos , Ferreira Fernanda Mylla Queiroz , Rodrigues Ingrid Kyelli Lima , Santos Itanara Barboza dos , Pereira Thais Alves Barreto , DeSantana Josimari Melo
Published: February 2025

Objective: To investigate the presence of functional deficits in people with chronic migraine during the interictal phase, focusing on cervical range of movement, intensity of pain during movement, cervical disability and physical activity levels. Method: Observational case-control study carried out with patients with chronic migraine and healthy individuals between January 2019 and March 2020, aged between 18 and 55 years. Cervical range of movement (inclinometer), intensity of pain during movement (Numerical Pain Scale), cervical disability (Cervical Disability Index) and level of physical activity (International Physical Activity Questionnaire) were measured. Results: 32 patients with chronic migraine and 32 healthy controls were included. The group with chronic migraine had a lower range of motion in all cervical movements (p<0.05), except right cervical rotation (p= 0.054), as well as greater pain intensity during extension (p=0.012) and right rotation (p= 0.015). Cervical disability was significantly higher in the migraine group when compared to the control group (p<0.001). The level of physical activity was similar between the groups (p= 0.839). Conclusion: This study demonstrated that individuals with chronic migraine in the interictal phase present several functional deficits compared to healthy individuals. Specifically, we observed a significant reduction in cervical range of motion, a greater intensity of pain with cervical movement in some cases, and cervical disability ranging from mild to moderate. However, there was no significant difference in physical activity levels between the groups.
Analysis of the reaction time and balance between community and institutionalized elderly people
Authors: Reis Adrielli de Cássia Nogueira , Souza Carla Aparecida Gonçalves Poppinger , Pereira Júlia Morais , Alves Ricardo da Silva
Published: February 2025

Objective: To compare hip reaction time and postural balance between community-dwelling and institutionalized elderly individuals. Method: We conducted a cross-sectional, controlled study. Thirty-four elderly volunteers were assessed and allocated to two groups: the Community-Dwelling Elderly Group (CDEG) (age= 68.630 ± 5.353 years; BMI= 27.464 ± 3.185 kg/m2) and the Institutionalized Elderly Group (IEG) (age= 72.080 ± 5.123 years; BMI= 26.091 ± 4.189 kg/m2). All participants were evaluated for postural balance using right and left single-leg stance tests, both with and without vision, and hip abduction total reaction time using the PhysioPlay device equipped with the KinectTM sensor (Microsoft, USA). Results: A significant difference between the groups was observed in single-leg stance time with eyes open (Left: p= 0.004; Right: p= 0.001) and with eyes closed (Left: p= 0.044; Right: p= 0.037). The reaction time for hip abduction in both hips did not show significant differences between the groups (p>0.05). Conclusion: The IEG exhibited shorter single-leg support time on both legs compared to the CDEG, no differences in hip abduction reaction time, indicating that reaction time is impaired in both groups.
Aquisição de uma habilidade motora de alcance e manipulação em crianças com paralisia cerebral classificadas nos níveis I e II do Sistema de Classificação da Habilidade Manual (MACS): relato de casos
Authors: Costa Isabella Vendramini , Oliveira Rafael Pereira , Perez Danielle Borrego
Published: February 2025

Cerebral palsy (CP) is primarily a neuromotor disorder that affects movement development, muscle tone, and posture. Children with CP may present sensory-motor impairments that can impact the execution of upper limb movements, affecting daily living activities. The Manual Ability Classification System (MACS) describes how children with CP use theus hands to manipulate objects. Objective: To evaluate whether children with CP classified at levels I and II on the MACS scale show differences in learning a reaching and manipulation skill. Method: Case report that includes 2 children with CP, both 4 years old, classified at levels I and II on the MACS scale. A training session was conducted for a reaching and manipulation task. Variables included execution time of sequences, average time within blocks, and the first attempt as pre-test and the last attempt as post-test measures. Results: The child with CP classified at level I on the MACS scale there was a significant improvement in the reach and manipulation task, with a reduction of 35.53%, in contrast, the child classified at level II did not show a reduction in execution time but rather a 4.76% increase. Conclusion: The child with MACS level I had better performance on the task when compared to the child with MACS level II.
Pseudosperma parvisporum sp. nov., (Inocybaceae, Basidiomycota) from Pakistan
Authors: ABBAS ALI , NASEER AROOJ , KHALID ABDUL NASIR
Published: February 2025

A new species Pseudosperma parvisporum is described and illustrated here, based on morpho-anatomical and molecular phylogenetic characterization. The taxon is characterized by campanulate to becoming plano-convex to convex pileus at maturity, having 3.4–4.5 cm diam., with brown umbo, brownish golden to yellow fibrils spread on; up to 8 cm stipe, hollow, cylindrical and containing longitudinal striations on it; smaller basidiospores (8.86–10.86 × 5.06–6.2 μm); oblong to utriform, appeared in cluster cheilocystidia having 34.3–51.5 × 9.6–14.6 μm size and occurrence of fusiform to lageniform caulocystidia measuring 38.7 × 9.7 μm. In addition to these, the combined nrITS and nrLSU based phylogenetic analysis was done which supports its unique position and confirms it a new species as it forms a separate clade. The photographs, drawings and comparison with similar taxa are also provided here.
Final stage phyllosoma of Galearctus sp. (Decapoda: Scyllaridae) from the Coral Sea
Authors: LUENGO ELENA , GENIS-ARMERO REBECA , CLARK PAUL F. , PALERO FERRAN
Published: February 2025

Larval stages are known for only four out of eight Galearctus Holthuis, 2002 (Crustacea: Scyllaridae) species, a slipper lobster genus widely distributed throughout the Indo-Pacific region. DNA barcoding analyses of phyllosomae collected from the Coral Sea by the Australian Institute of Marine Science suggest the presence of two new genetic clades in the area, for which larvae cannot be discriminated morphologically. The last instar larva of an unknown species of Galearctus is described and illustrated in detail here. It is possible that this larval material may be assigned to G. umbilicatus, the only species of the genus lacking a DNA barcode. Morphological analyses and a literature review allowed the re-evaluation of previous Galearctus larval studies, identifying several misidentifications and inconsistencies. Further morphological and molecular revision of adult Galearctus species is required to confirm larval identities, but the results presented here indicate that the diversity of Galearctus may be underestimated.
Two new species of the genus Zaitzeviaria Nomura, 1959 (Coleoptera: Elmidae) from China
Authors: JIANG RI-XIN , CHEN XIANG-SHENG
Published: February 2025

Two new species of the genus Zaitzeviaria Nomura, 1959 are described and figured from Southwest China: Zaitzeviaria chenzhitengi sp. nov. from Yunnan Province and Zaitzeviaria guiyangensis sp. nov. from Guizhou Province. A key to Chinese Zaitzeviaria species is provided.
Robust Difference and Ratio Type Estimators in Presence of  Correlated Measurement Errors  Under Ranked Set Sampling
Authors: Bhushan Shashi , Kumar Anoop
Published: February 2025

In survey sampling, the problem of correlated measurement errors (CMEs) was initially addressed using conventional estimators under simple random sampling (SRS) and ranked set sampling (RSS). To evaluate the impacts of CMEs, this study proposes some robust difference and ratio types of estimators using RSS methodology. The statistical properties like bias and mean square error are derived up to a first-order approximation. An extensive simulation study is performed, and the results are obtained, which exhibit the robustness of the proposed estimators compared to their conventional counterparts.

AMS 2000: MSC2020:62D05
Empowering Language Learners: Redefining Authentic Resources Through Community Engagement
Authors: Frantz Katelin
Published: February 2025

This paper explores a transformative approach to language education through a project undertaken by middle school Spanish 1 students. By engaging with real-world contexts and producing materials that serve a genuine purpose within their community, students redefine the notion of ‘authentic resources’ in language education. The implications of this innovative practice extend beyond language education, pointing towards a future where learners are empowered to become active agents of change in their communities. This paper underscores the importance of experiential learning experiences that transcend the classroom and prioritize authenticity, community engagement and meaningful learning experiences.
Intellectual Humility Predicts Empathic Accuracy and Empathic Resilience
Authors: Lehmann Michal , Genzer Shir , Kassem Nur , Van Tongeren Daryl R. , Perry Anat
Published: February 2025

Three preregistered studies ( N = 533) investigated the relationship between intellectual humility (IH) and cognitive and emotional empathy. Study 1 ( n = 212) revealed a positive association between IH and empathic accuracy (EA), especially toward the outgroup. Study 2 ( n = 112) replicated the significant association between IH and EA. Study 3 ( n = 209) employed a manipulation to enhance IH to demonstrate causality. We found evidence for an indirect effect, wherein the manipulation increased state IH, which was associated with greater EA. A mini meta-analysis revealed that, on average, individuals with higher levels of IH exhibit increased EA, showing a greater understanding of others’ emotional states. Moreover, IH predicts empathic resilience—buffering against personal distress while maintaining or increasing empathic concern for others. These findings highlight the positive influence of IH on empathy, emphasizing its potential for fostering deeper connections and better understanding in social interactions.
The associations of obesity with demographic and lifestyle factors among Hong Kong adults
Authors: Yip Cynthia Sau Chun
Published: February 2025

Background: Obesity is a risk factor for leading causes of death. Aim: This study investigated the associations of obesity with demographic and lifestyle factors among adults aged 18–64 in Hong Kong. Methods: The study uses data ( n = 24,855) from the government online database. It uses T-tests to compare mean values for body mass index (BMI), waist circumference, and weight-to-height ratio obese; analysis of variance for not-obese, BMI-obese-only, central-obese, and BMI + central-obese; Pearson chi-square tests for categorical variables; and multinomial logistic regression to obtain the odd ratios. It uses IBM SPSS version 26 to conduct all analyses, and at a 95% confidence level. Results: The analyses show that the risks of central-obese, and BMI + central-obese increase by 4%, and 4%/year of age, respectively. Females have 60%, 38%, and 60% lower risks of BMI-obese-only, central-obese, and BMI + central-obese, respectively, and people with tertiary education have 28%, 20%, and 20% lower risks, respectively. Employed people have a 40% higher risk of BMI-obese-only when compared with the unemployed; students have a 46% lower risk of BMI + central-obese and home-makers have a 38% higher risk. The risk of central-obese decreases by 14%/10 min/day of moderate physical activity, but could be different among females, and vigorous physical activity yielded mixed results. The risk of BMI + central-obese decreases by 9%/day/week of vegetable intake. Conclusions: Obesity is associated with multiple demographic and lifestyle factors. Keep doing vigorous and moderate physical activity but state alert to obesity risk factors, and frequent vegetable intake are recommended. Lifelong learning and continuing education could be an effective strategy to combat obesity.
Improved diamond particle reactivity by alumina coating
Authors: Ishida H. , Shibuta K. , Groner M.
Published: February 2025

Diamond has the highest thermal conductivity of all bulk materials, making it one of the most promising thermally conductive fillers for thermal interface materials (TIMs). However, the commercial use of diamond for this purpose remains limited because the chemically inert diamond surface prevents mixing with polymer matrices. Hence, it would be helpful to improve the reactivity of the diamond surface without reducing the thermal conductivity of the diamond particles themselves. The present work used atomic layer deposition (ALD) to selectively modify the surface characteristics of diamond particles by applying an ultrathin conformal alumina film. Film thicknesses of 0.6–0.8 nm and 1.0–1.4 nm were obtained after five and ten ALD cycles, respectively. The deposited alumina had an amorphous structure and the modified diamond surfaces exhibited greatly enhanced chemical reactivity as demonstrated using a labeling agent. A TIM fabricated using alumina-coated diamond particles with a polydimethylsiloxane matrix showed improved thermal conductivity and flow rate. The alumina film effectively interacted with surfactants in the polymer matrix to improve the miscibility of the TIM components.
Intravenous amino acids for kidney protection in patients undergoing cardiac surgery: A systematic review and meta-analysis of randomized controlled trials
Authors: Khan Malik Waleed Zeb , Ali Aizaz , Hussain Amna , Mian Aban Masaud , Moeez Abdul , Inayat Waqas , Noor Bushra , Shah Izhar Ali , Osama Muhammad , Khan Bushra , Sajid Muhammad , Azeem Touba , Ebad Ur Rehman Mohammad , Ali Ashraf , Afridi Ubaid Khan
Published: February 2025

Objective

To evaluate the efficacy of intravenous (IV) amino acids in preventing acute kidney injury (AKI) in patients undergoing cardiac surgery.

Methods

PubMed, EMBASE, and Cochrane Library databases were systematically searched for all relevant randomised controlled trials (RCTs) published from inception to July 25, 2024. A random effects model was used to pool the risk ratios (RR) for dichotomous outcomes, and the combined data was visually represented using forest plots.

Results

3 studies involving 3646 patients were included in the meta-analysis. IV amino acids did not significantly lower the overall AKI incidence compared with control measures. However, they significantly reduced the risk of Stage 1 AKI and Stage 3 AKI. No differences were observed between intervention and control for Stage 2 AKI or need for kidney replacement therapy.

Conclusion

IV amino acids may offer protective benefits against severe AKI stages in cardiac surgery patients. Further studies are warranted to validate our findings.
Solving the paradox of Lean Management’s low success rate
Authors: Samson Danny , Ho William , Seyedghorban Zahra , Bevington Diana , Kelly Sally
Published: February 2025

This study investigates problems related to the high variance in the success rate of lean implementations, using a unique data set from a specific approach to implementing lean. We develop insights about how to effectively resolve the ‘Lean paradox’, namely that Lean concepts promise so much in theory yet deliver infrequently in practice. Our primary data of 268 Lean implementation initiatives illuminates the core elements of lean implementation success that explain this success variance. We present an in-depth case study of that specific method of lean implementation. Lean implementation success occurs when specific processes are followed, namely integration of job role and process analysis, comprehensive end-to-end deployment rather than spot-based problem solving, use of operator-based data about processes and waste, detailed level of data and change deployment focussed on waste reduction, and ongoing measurement and control of process changes. These ‘how’ factors provide both conceptual and practical insights for managers.

JEL Classification: M11
Rediscovering Telsa
Authors: Oberkircher Fred , Kirby Lee
Published: February 2025

More than a historical footnote from the 19th Century, inventor Nikola Tesla can provide inspiration to today's generation of engineering students
Welcome to the Inner Circle
Authors: Lowe Roslyn
Published: February 2025

From its exterior canopy to its lobby and theater house, The Rose Theatre Brampton in Ontario boasts a full cast of customized lighting elements
Quiet and under Control
Authors: Tarricone Paul
Published: February 2025

Light is an inconspicuous yet welcome guest at New York's Mandarin Oriental hotel
The Incredible Disappearing Incandescent Lamp
Authors: Altman Emlyn
Published: February 2025

The incandescent lamp is not trendy or chic, but have stories of its death been greatly exaggerated? Hospitality applications may still offer a home
Culturally Sound
Authors: Kobes John-Michael
Published: February 2025

With its simple, low-key.lighting, the Inn of the Mountain Gods Resort and Casino pays homage to its Apache roots and wilderness surroundings
Indications for Lateral Extra-articular Tenodesis in Anterior Cruciate Ligament Reconstruction: A Systematic Review
Authors: Zabrzyński Jan , Kwapisz Adam , Erdmann Jakub , Zabrzyńska Maria , Błachowski Michał , Ohla Jakub , Adamczyk Michalina , Sokołowski Maciej , Majchrzak Bartosz , Huri Gazi
Published: February 2025

Background:

The anterior cruciate ligament (ACL) is a major sagittal plane stabilizer of the knee joint. Even if anterior laxity can be brought under control by utilizing modern surgical techniques, internal rotational instability may not always be controlled adequately. Various surgical techniques are used to prevent this coronal or rotational instability, such as lateral extra-articular tenodesis (LET). Despite an abundance of articles in recent decades discussing LET in ACL reconstruction, no definitive indicators for extra-articular tenodesis have been described in the literature.

Purpose:

Given the scarcity of literature assessing the indications in LET, the purpose of this study was to conduct a systematic review of the described indications for this operation in the context of concurrent ACL reconstruction.

Study Design:

Systematic review; Level of evidence, 4.

Methods:

We searched PubMed, Cochrane Central, ScienceDirect, Web of Science, and Embase using the following key terms with no limits regarding the year of publication: (extraarticular OR extraarticular) AND (tenodesis OR plasty OR augmentation OR procedure or reconstruction OR reconstructive OR surgical OR surgery OR technique) AND (ACL OR anterior cruciate ligament). We included clinical human studies based on levels of evidence 1 to 4 that were written in English. We excluded studies not written in English, case studies, reviews, letters to editors, conference abstracts, or studies containing incomplete or irrelevant data.

Results:

The analysis evaluated 29 articles published between 1999 and 2023. We evaluated mostly level 3 (n = 13) and level 4 (n = 12) evidence; however, there were 4 articles with level 1 evidence. The majority of the studies were retrospective (n = 21), although there were prospective studies (n = 8). The mean age of the participants was 24.4 years. The most prevalent indications for LET were high-risk sports (16 articles), medial meniscal repair/excision (11 articles), and pivot-shift test grades 2 and 3 (11 articles).

Conclusion:

The reviewed articles showed reduced pivoting and laxity, improved clinical outcomes, and decreased revision rates after primary ACL reconstruction. The main frequent and repeated indications for using LET in ACL reconstruction are meniscal surgery, sports activity, and grade 2 and 3 pivoting.
Multi-scale analysis of mechanical properties of RCA based on synergistic modification of carboxylic butadiene-styrene latex and PVA fiber
Authors: Zhang Peng , Zheng Liming , Yi Lingbing , Ren Fangyi
Published: February 2025

With the rapid development of the construction industry, construction waste is also increasing day by day. Considering the utilization rate of recycled coarse aggregate (RCA) concrete and the mechanical strength of RCA itself, this study carried out collaborative modification of RCA through new modifiers carboxylic butadiene-styrene latex (CSBL) and PVA fiber, aiming at improving the mechanical properties of RCA. In this study, compressive test and shear test were used to test the mechanical strength of the test block. Scanning electron microscope (SEM) and Fourier transform infrared spectrometer (FTIR) were used to reveal the microscopic morphology and chemical composition, respectively. Molecular dynamics simulation was used to evaluate the type and stability of the force at the weak interface. The results showed that the modified compressive strength and shear strength of RCA with replacement rate of 20% increased by 12.8% and 26.7%, and the optimal content of CSBL and PVA fiber was 15% and 1.5%, respectively. CSBL further hydrates the unhydrated cement, thereby optimizing the weak interface. PVA plays a role in limiting the development of cracks in RCA. The results of weak interface molecular simulation show that CSBL acts as a bridge at the weak interface, and CSBL mainly enhances the adhesion between the weak interfaces in RCA through a large number of hydrogen bonds and stable ionic bonds. Therefore, CSBL improves the application effect of PVA fiber in RCA, and this study provides useful insights for improving the performance of RCA materials.
Early Check-In Protocol: Identifying Medication Issues in Patients with Cancer at Health System Specialty Pharmacy
Authors: Phillips Kayla Ann , Wash Andrew , Hutchinson Kristin , Cash Katie Jo , Giavatto Carly , Fitzpatrick Casey , Hunter Abbey , Page Olivia , Mourani Jessica , Lopez-Medina Ana I
Published: February 2025

Introduction

Several studies have illustrated value in early patient contact following oral anticancer medication (OAM) initiation, particularly within the first 14 days of therapy, as adverse effects may lead to early discontinuation or poor adherence. Health-system specialty pharmacies (HSSPs) are optimally positioned to adopt this best practice through formalized protocols designed to identify and mitigate medication-related issues.

Objective

To outline an HSSP-led early check-in protocol for patients taking OAMs and to describe the subsequent interventions conducted by the HSSP team and their acceptance rate.

Results

HSSPs enacted a protocol in January 2021 requiring oncology pharmacists - to contact patients within 14 days of OAM initiation, aiming to optimize adverse effect management, offer supportive care, address adherence, and provide education. To evaluate the impact of the early check-in protocol, we conducted a retrospective, multicenter, observational study across CPS’s health system clients from January 2022 to November 2023. HSSP pharmacists created 1698 interventions for 1184 patients from the early check-in. The cancer types most frequently associated with an intervention were breast (n = 431, 25.4%), gastrointestinal (n = 245, 14.4%), and prostate (n = 206, 12.1%). The most frequent intervention categories were adverse drug reactions (ADRs) (n = 1,548, 91.2%) and adherence (n = 55, 3.2%). Overall, 95.5% of pharmacist recommendations were accepted by patients and/or providers.

Conclusion

Implementing an early check-in protocol allows HSSP pharmacists to mitigate barriers to OAM adherence. This study emphasizes the importance of early check-in and illustrates the scope of the oncology pharmacist’s role by evaluating critically meaningful interventions and quantifying pharmacist recommendations and acceptance rate.
Energy saving and corrosion control by heat recycling in re-baking process of graphite electrode manufacturing
Authors: Yadav Ranjana , Sharma Ashok Kumar , Sharma Sarita
Published: February 2025

In the graphite electrode manufacturing industry, the re-baking process is energy-intensive and poses significant challenges due to heat loss and corrosion of equipment. The current work focuses on developing an innovative approach to enhance energy efficiency and control corrosion through heat recycling. The proposed method, heat recycling and corrosion control, involves capturing waste heat generated during the re-baking process and redirecting it to preheat the electrodes, thereby reducing overall energy consumption. Key parameters investigated include the temperature profile, heat transfer rate, and the rate of corrosion in the furnace components. This approach explores potential methods to enhance the energy efficiency of an operational oil-fired re-baking furnace. The findings indicate a notable 19.56% improvement in heat transfer rates based on data collection and analysis. Additionally, the combustion air volume increased by 25.49%, while the temperature rose by 66.67%. The study also identified opportunities for energy savings, with a reduction of 26.08% in power consumption and 40% in oil usage per hour. The study demonstrates that the HRCC method not only conserves energy but also mitigates corrosion-related damages, leading to lower operational costs. Future work will focus on optimizing the heat recovery system, scaling the method for industrial applications, and exploring the integration of advanced materials to further enhance corrosion resistance. The HRCC approach holds promise for widespread application in the graphite electrode manufacturing industry, contributing to sustainable production practices and reduced environmental impact.
Adsorptive removal of nickel from waste water using synthesized sodium alginate encapsulated magnetic graphene oxide nanoadsorbent from Strychnous Potatorum seeds
Authors: Janani Rameshbabu , Baskar Gurunathan , Pravin Ravichandran , Sivakumar Kandhasamy
Published: February 2025

The present study investigated the synthesis of sodium alginate encapsulated magnetic graphene oxide (SAMGO) beads from Strychnous Potatorum seeds. The synthesized SAMGO beads were investigated for adsorptive removal of nickel from aqueous solution. The synthesized SAMGO beads were characterized for surface morphology, functional groups, magnetic property and phase identification using SEM, FT-IR, VSM and XRD analysis. The optimization process involving the SAMGO beads for adsorptive removal of nickel resulted in maximum removal rate under the conditions of contact time – 15 min, SAMGO bead dose – 10 mg/50 mL of solution, nickel ion concentration – 50 mg/L, pH-9 and temperature of 30 °C. Adsorption of nickel onto SAMGO beads was well studied by pseudo-second-order kinetic studies. Also, the adsorption equilibrium study was well fitted towards Freundlich isotherm ( R2 = 0.99). The findings from the regeneration studies demonstrated that the selected desorbing agents, 0.5 M HCl and 0.5 M EDTA were well-suited for desorption. After five experimental cycles, the desorption efficiency decreased by only 10.93% and 7.76% using 0.5 M HCl and 0.5 M EDTA, respectively indicating that the SAMGO beads for reusability. The synthesized SAMGO beads have shown potential to reuse, nontoxic green adsorbent with maximum removal rate.
Balancing act: The role of risk, cost, benefit, and opportunity in green energy decision making
Authors: Chung Kuo Cheng , Kuo Szu-Yu , Xie Zong-Min
Published: February 2025

This research examines the strategic development and progress of green energy initiatives on offshore islands under the auspices of the Chinese government. The primary methodologies employed are the Decision Making Trial and Evaluation Laboratory and the analytic network process, in conjunction with the VIKOR method. The analysis focuses on four primary dimensions: benefits, opportunities, costs, risks, and their respective subdimensions. Results indicate the need to consider risk first, followed by cost, benefit, and opportunity. They also underscore the importance of the government focusing on risk management and cost-effectiveness when implementing green energy infrastructure. Subsequently, the potential benefits and opportunities should be evaluated to enhance the effectiveness of green energy systems in Taiwan's offshore islands and ensure optimal operational efficiency.
Non-linear Relationship Between Board Gender Diversity and Research and Development Intensity: Does National Gender Inequality Matter?
Authors: Varrone Nicola , Colurcio Maria , Caridà Angela , Melia Monia
Published: February 2025

This article explores the relationship between board gender diversity and research and development investments in the technology industry. The study employs a multi-theoretical framework based on the constructs of upper echelon theory, resource-dependency theory and on the literature on women’s attitude towards risk assessment. We adopt a panel data set of 390 technology firms over the study period 2009–2019. Our empirical research unveils an inverted curvilinear (U-shaped) relationship between board gender diversity and research and development investments, with national gender inequality negatively moderating this relationship. This study introduces an innovative framework that integrates considerations at both the micro level (the relationship between board gender diversity and research and development intensity) and the macro level (the moderating role of national gender inequality), offering a more comprehensive understanding of the multifaceted factors influencing firms’ investments in research and development initiatives. Our findings provide critical insights for enhancing gender diversity in corporate settings, serving both academic research and practical managerial and policymaking endeavours.
Accidental Foreign Body Near-aspiration in a Neonate—An Unexpected Cause in the NICU
Authors: Hazarika Jayanta , Sohane Arpit , Nagpal Rema , Suryawanshi Pradeep
Published: February 2025

Foreign body aspiration (FBA) is a frequent entity in infants and toddlers, but very rare in neonates. We present an unusual case of a term neonate, who developed sudden desaturation and worsening respiratory distress with stridor, during the course of hospitalization in the Neonatal Intensive Care Unit. A pre-intubation bronchoscopic evaluation revealed a foreign object (“luer-lock” plug of an intravenous cannula), which was seen in the laryngopharynx, partially obstructing the cords, leading to severe respiratory distress. This was removed by forceps, with a resultant dramatic improvement. This case highlights the possibility of the accidental aspiration of a commonly used piece of medical equipment in the NICU and emphasizes the need for extreme vigilance on the part of healthcare workers and providers in the prevention of such events.
Reaching American Indian Parents Through Online Divorce Education
Authors: Turner Joshua J. , Higginbotham Brian J. , Bradford Kay , Schramm David G.
Published: February 2025

Evaluative research on the effectiveness of divorce education continues to grow, but research is still limited on programmatic impacts for historically underserved groups. Using a mixed-methods design, this study analyzed data from divorcing American Indian parents ( n = 153) who took part in a court-mandated, online divorce education program. The study examined participants’ reasons for divorce, understanding of divorce and coparenting plans, and participant experiences in the course. Quantitative analyses revealed that mothers reported more problems than fathers in terms of what influenced their decision to divorce, which included emotional, psychological, and verbal mistreatment, childrearing differences, extended family issues, and physical violence. Both mothers and fathers demonstrated an improved understanding of divorce-related topics and positive coparenting practices. Qualitative analyses demonstrated parallels with quantitative analyses, as an increased awareness of the effects of divorce on children was most frequently mentioned as the greatest benefit to participation. Participants also noted their appreciation for the program's online content and delivery method, while acknowledging how the program helped them learn more about coparenting. Implications for facilitating divorce education programs with American Indian parents are discussed.