bluuebunny/crossref_metadata_2025 huggingface dataset:
Patterns of Apoptosis and Proliferation throughout the Biennial Reproductive Cycle of Viviparous Female Typhlonectes compressicauda (Amphibia, Gymnophiona)
Authors: Raquet Michel , Brun Claire , Exbrayat Jean-Marie
Published: December 2016

Typhlonectes compressicauda is an aquatic gymnophionan amphibian living in South America. Its breeding cycle is linked to seasons, characterized by a regular alternation of rainy and dry seasons. During a complex biennial cycle, the female genital tract undergoes a series of alternations of increasing and decreasing, governed by equilibrium of proliferation and apoptotic phenomena. Immunohistochemical methods were used to visualize cell proliferation with the detection of Ki67 antibody, a protein present in proliferative cells; terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL) and Apostain were performed to detect apoptotic cells on sections of ovaries and oviducts. In ovaries, both phenomena affect the germinal nests and follicles according to the cycle period. In the oviduct, the balance was in favor of proliferation during preparation for reproduction, and in favor of apoptosis when genital ducts regress. Apoptosis and proliferation are narrowly implicated in the remodeling of the genital tract and they are accompanied by the differentiation of tissues according to the phase of the breeding cycle. These variations permit the capture of oocytes at ovulation, always at the same period, and the parturition after 6–7 months of gestation, at a period in which the newborns live with their mother, protected in burrows in the mud. During the intervening year of sexual inactivity, the female reconstitutes body reserves.
Implicating Cryptic and Novel Anophelines as Malaria Vectors in Africa
Authors: Stevenson Jennifer , Norris Douglas
Published: December 2016

Entomological indices and bionomic descriptions of malaria vectors are essential to accurately describe and understand malaria transmission and for the design and evaluation of appropriate control interventions. In order to correctly assign spatio-temporal distributions, behaviors and responses to interventions to particular anopheline species, identification of mosquitoes must be accurately made. This paper reviews the current methods and their limitations in correctly identifying anopheline mosquitoes in sub-Saharan Africa, and highlights the importance of molecular methods to discriminate cryptic species and identify lesser known anophelines. The increasing number of reports of Plasmodium infections in assumed “minor”, non-vector, and cryptic and novel species is reviewed. Their importance in terms of evading current control and elimination strategies and therefore maintaining malaria transmission is emphasized.
Elaboration of Luminescent and Magnetic Hybrid Networks Based on Lanthanide Ions and Imidazolium Dicarboxylate Salts: Influence of the Synthesis Conditions
Authors: Farger Pierre , Leuvrey Cédric , Gallart Mathieu , Gilliot Pierre , Rogez Guillaume , Rabu Pierre , Delahaye Emilie
Published: December 2016

The syntheses and characterization of four new hybrid coordination networks based on lanthanide ions (Ln = Nd, Sm) and 1,3-carboxymethylimidazolium (L) salt in the presence of oxalic acid (H2ox) are reported. The influence of the synthesis parameters, such as the nature of the lanthanide ion (Nd3+ or Sm3+), the nature of the imidazolium source (chloride [H2L][Cl] or zwitterionic [HL] form) and the presence or not of oxalic acid (H2ox), is discussed. In the presence of oxalic acid, the samarium salt gives only one compound [Sm(L)(ox)(H2O)]·H2O, whatever the nature of the imidazolium ligand, while the neodymium salt leads to three different compounds, [Nd(L)(ox)(H2O)]·H2O, [Nd(L)(ox)0.5(H2O)2][Cl] or [Nd2(L)2(ox)(NO3)(H2O)3][NO3], depending on the imidazolium ligand. In the absence of oxalic acid, gels are obtained, except for the reaction between the neodymium salt and [H2L][Cl], which leads to [Nd(L)(ox)(H2O)]·H2O. All compounds crystallized and their structures were determined by single crystal diffraction. The description of these new phases was consistently supported by ancillary techniques, such as powder X-ray diffraction, thermal analyses and UV-visible-near infrared spectroscopy. The luminescent and magnetic properties of the three pure compounds [Sm(L)(ox)(H2O)]·H2O, [Nd(L)(ox)(H2O)]·H2O and [Nd2(L)2(ox)(NO3)(H2O)3][NO3] were also studied.
Solution of the Master Equation for Quantum Brownian Motion Given by the Schrödinger Equation
Authors: Sinuvasan R. , Paliathanasis Andronikos , Morris Richard , Leach Peter
Published: December 2016

We consider the master equation of quantum Brownian motion, and with the application of the group invariant transformation, we show that there exists a surface on which the solution of the master equation is given by an autonomous one-dimensional Schrödinger Equation.
Optimization of Setting Take-Profit Levels for Derivative Trading
Authors: Rui Xiaodong , Liu Yue , Yang Aijun , Yang Hongqiang , Zhang Chengcui
Published: December 2016

This paper develops an optimal stopping rule by characterizing the take-profit level. The optimization problem is modeled by geometric Brownian motion with two switchable regimes and solved by stochastic calculation. A closed-form profitability function for the trading strategies is given, and based on which the optimal take-profit level is numerically achievable with small cost of computational complexity.
Development of a UPLC-TQ/MS Approach for the Determination of Eleven Bioactive Components in Haizao Yuhu Decoction Plus-Minus Haizao and Gancao Drug Combination after Oral Administration in a Rat Model of Hypothyroidism
Authors: Ma Yingchang , Zhang Yang , Zhai Yuanjuan , Zhu Zhenhua , Pan Ying , Qian Dawei , Su Shulan , Fan Xinsheng , Duan Jinao
Published: December 2016

Haizao Yuhu Decoction (HYD) has been used for approximately 500 years and is well-known in Traditional Chinese Medicine for its efficacy in the treatment of thyroid-related diseases. In this study, a rapid liquid chromatography-tandem mass spectrometry method was developed for the determination of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin, osthole, and glycyrrhetinic acid in rat plasma to investigate the pharmacokinetic profile of different HYD prescriptions in a rat model of hypothyroidism. The differences in pharmacokinetic parameters among the groups were compared by Student’s t-test. The pharmacokinetic profile of liquiritin, naringin, hesperidin, peimine, liquiritigenin, glycyrrhizic acid, bergapten, nobiletin, osthole, and glycyrrhetinic acid showed significant differences between Haizao and Gancao anti-drug combination and other herbs in HYD. These results may contribute to the rational clinical use of HYD and reveal the compatibility profile of the Haizao and Gancao anti-drug combination.
The Scythe and the Pentagram: Santa Muerte from Folk Catholicism to Occultism
Authors: Hedenborg-White Manon , Gregorius Fredrik
Published: December 2016

Santa Muerte is establishing a presence among practitioners of contemporary occultism in Europe and North America. The occult milieu is highly different from the Mexican cult of Santa Muerte, having a strong heritage of secrecy and tradition as social capital and being mostly middle-class in orientation. Nonetheless, this Catholic folk saint with a mostly pragmatic, popular, and grassroots cult is becoming increasingly popular among occultists. Based on a survey of three recent books on Santa Muerte geared towards an Anglophone, occult audience, it is therefore the aim of this article to understand how and why the Skeleton Saint is attracting adherents in the occult milieu, by analyzing the underlying causes of this growing trend, as well as the conditions shaping it. It is the overall argument of this article that the beginning reception of Santa Muerte in occultism is a result of perceived needs and demands specific to the occult milieu rather than characteristics inherent in the symbol itself, and that an analysis of the ways in which she is spreading outside of her original sociocultural context must be guided by an understanding of the novel one she is integrated in.
A Unified Framework for Street-View Panorama Stitching
Authors: Li Li , Yao Jian , Xie Renping , Xia Menghan , Zhang Wei
Published: December 2016

In this paper, we propose a unified framework to generate a pleasant and high-quality street-view panorama by stitching multiple panoramic images captured from the cameras mounted on the mobile platform. Our proposed framework is comprised of four major steps: image warping, color correction, optimal seam line detection and image blending. Since the input images are captured without a precisely common projection center from the scenes with the depth differences with respect to the cameras to different extents, such images cannot be precisely aligned in geometry. Therefore, an efficient image warping method based on the dense optical flow field is proposed to greatly suppress the influence of large geometric misalignment at first. Then, to lessen the influence of photometric inconsistencies caused by the illumination variations and different exposure settings, we propose an efficient color correction algorithm via matching extreme points of histograms to greatly decrease color differences between warped images. After that, the optimal seam lines between adjacent input images are detected via the graph cut energy minimization framework. At last, the Laplacian pyramid blending algorithm is applied to further eliminate the stitching artifacts along the optimal seam lines. Experimental results on a large set of challenging street-view panoramic images captured form the real world illustrate that the proposed system is capable of creating high-quality panoramas.
Energy and Quality Evaluation for Compressive Sensing of Fetal Electrocardiogram Signals
Authors: Da Poian Giulia , Brandalise Denis , Bernardini Riccardo , Rinaldo Roberto
Published: December 2016

This manuscript addresses the problem of non-invasive fetal Electrocardiogram (ECG) signal acquisition with low power/low complexity sensors. A sensor architecture using the Compressive Sensing (CS) paradigm is compared to a standard compression scheme using wavelets in terms of energy consumption vs. reconstruction quality, and, more importantly, vs. performance of fetal heart beat detection in the reconstructed signals. We show in this paper that a CS scheme based on reconstruction with an over-complete dictionary has similar reconstruction quality to one based on wavelet compression. We also consider, as a more important figure of merit, the accuracy of fetal beat detection after reconstruction as a function of the sensor power consumption. Experimental results with an actual implementation in a commercial device show that CS allows significant reduction of energy consumption in the sensor node, and that the detection performance is comparable to that obtained from original signals for compression ratios up to about 75%.
A Multi-Sensor Fusion MAV State Estimation from Long-Range Stereo, IMU, GPS and Barometric Sensors
Authors: Song Yu , Nuske Stephen , Scherer Sebastian
Published: December 2016

State estimation is the most critical capability for MAV (Micro-Aerial Vehicle) localization, autonomous obstacle avoidance, robust flight control and 3D environmental mapping. There are three main challenges for MAV state estimation: (1) it can deal with aggressive 6 DOF (Degree Of Freedom) motion; (2) it should be robust to intermittent GPS (Global Positioning System) (even GPS-denied) situations; (3) it should work well both for low- and high-altitude flight. In this paper, we present a state estimation technique by fusing long-range stereo visual odometry, GPS, barometric and IMU (Inertial Measurement Unit) measurements. The new estimation system has two main parts, a stochastic cloning EKF (Extended Kalman Filter) estimator that loosely fuses both absolute state measurements (GPS, barometer) and the relative state measurements (IMU, visual odometry), and is derived and discussed in detail. A long-range stereo visual odometry is proposed for high-altitude MAV odometry calculation by using both multi-view stereo triangulation and a multi-view stereo inverse depth filter. The odometry takes the EKF information (IMU integral) for robust camera pose tracking and image feature matching, and the stereo odometry output serves as the relative measurements for the update of the state estimation. Experimental results on a benchmark dataset and our real flight dataset show the effectiveness of the proposed state estimation system, especially for the aggressive, intermittent GPS and high-altitude MAV flight.
A Quantitative Groundwater Resource Management under Uncertainty Using a Retrospective Optimization Framework
Authors: Kifanyi Gislar , Ndambuki Julius , Odai Samuel
Published: December 2016

Water resources are a major concern for any socio-economic development. As the quality of many surface fresh water sources increasingly deteriorate, more pressure is being imparted into groundwater aquifers. Since groundwater and the aquifers that host it are inherently vulnerable to anthropogenic impacts, there is a need for sustainable pumping strategies. However, groundwater resource management is challenging due to the heterogeneous nature of aquifer systems. Aquifer hydrogeology is highly uncertain, and thus it is imperative that this uncertainty is accounted for when managing groundwater resource pumping. This, therefore, underscores the need for an efficient optimization tool which can sustainably manage the resource under uncertainty conditions. In this paper, we apply a procedure which is new within the context of groundwater resource management—the Retrospective Optimization Approximation (ROA) method. This method is capable of designing sustainable groundwater pumping strategies for aquifers which are characterized by uncertainty arising due to scarcity of input data. ROA framework solves and evaluates a sequence of optimization sub-problems in an increasing number of realizations. We used k-means clustering sampling technique for the realizations selection. The methodology is demonstrated through application to an hypothetical example. The optimization problem was solved and analyzed using “Active Set” algorithm implemented under MATLAB environment. The results indicate that the ROA sampling based method is a promising approach for optimizing groundwater pumping rates under conditions of hydrogeological uncertainty.
Reduction Operators and Exact Solutions of Variable Coefficient Nonlinear Wave Equations with Power Nonlinearities
Authors: Huang Dingjiang , Zhu Yan , Yang Qinmin
Published: December 2016

Reduction operators, i.e., the operators of nonclassical (or conditional) symmetry of a class of variable coefficient nonlinear wave equations with power nonlinearities, are investigated within the framework of a singular reduction operator. A classification of regular reduction operators is performed with respect to generalized extended equivalence groups. Exact solutions of some nonlinear wave models, which are invariant under certain reduction operators, are also constructed.
Role of p38alpha/beta MAP Kinase in Cell Susceptibility to Clostridium sordellii Lethal Toxin and Clostridium difficile Toxin B
Authors: Schelle Ilona , Bruening Janina , Buetepage Mareike , Genth Harald
Published: December 2016

Lethal Toxin from Clostridium sordellii (TcsL), which is casually involved in the toxic shock syndrome and in gas gangrene, enters its target cells by receptor-mediated endocytosis. Inside the cell, TcsL mono-O-glucosylates and thereby inactivates Rac/Cdc42 and Ras subtype GTPases, resulting in actin reorganization and an activation of p38 MAP kinase. While a role of p38 MAP kinase in TcsL-induced cell death is well established, data on a role of p38 MAP kinase in TcsL-induced actin reorganization are not available. In this study, TcsL-induced Rac/Cdc42 glucosylation and actin reorganization are differentially analyzed in p38alpha−/− MSCV empty vector MEFs and the corresponding cell line with reconstituted p38alpha expression (p38alpha−/− MSCV p38alpha MEFs). Genetic deletion of p38alpha results in reduced susceptibility of cells to TcsL-induced Rac/Cdc42 glucosylation and actin reorganization. Furthermore, SB203580, a pyridinyl imidazole inhibitor of p38alpha/beta MAP kinase, also protects cells from TcsL-induced effects in both p38−/− MSCV empty vector MEFs and in p38alpha−/− MSCV p38alpha MEFs, suggesting that inhibition of p38beta contributes to the protective effect of SB203580. In contrast, the effects of the related C. difficile Toxin B are responsive neither to SB203580 treatment nor to p38alpha deletion. In conclusion, the protective effects of SB203580 and of p38alpha deletion are likely not based on inhibition of the toxins’ glucosyltransferase activity rather than on inhibited endocytic uptake of specifically TcsL into target cells.
Personalized Oncogenomics in the Management of Gastrointestinal Carcinomas—Early Experiences from a Pilot Study
Authors: Sheffield B.S. , Tessier-Cloutier B. , Li-Chang H. , Shen Y. , Pleasance E. , Kasaian K. , Li Y. , Jones S.J.M. , Lim H.J. , Renouf D.J. , Huntsman D.G. , Yip S. , Laskin J. , Marra M. , Schaeffer D.F.
Published: December 2016

Background: Gastrointestinal carcinomas are genomically complex cancers that are lethal in the metastatic setting. Whole-genome and transcriptome sequencing allow for the simultaneous characterization of multiple oncogenic pathways. Methods: We report 3 cases of metastatic gastrointestinal carcinoma in patients enrolled in the Personalized Onco-Genomics program at the BC Cancer Agency. Real-time genomic profiling was combined with clinical expertise to diagnose a carcinoma of unknown primary, to explore treatment response to bevacizumab in a colorectal cancer, and to characterize an appendiceal adenocarcinoma. Results: In the first case, genomic profiling revealed an IDH1 somatic mutation, supporting the diagnosis of cholangiocarcinoma in a malignancy of unknown origin, and further guided therapy by identifying epidermal growth factor receptor amplification. In the second case, a BRAF V600E mutation and wild-type KRAS profile justified the use of targeted therapies to treat a colonic adenocarcinoma. The third case was an appendiceal adenocarcinoma defined by a p53 inactivation; Ras/RAF/MEK, Akt/mTOR, Wnt, and NOTCH pathway activation; and overexpression of RET, ERBB2 (HER2), ERBB3, MET, and cell cycle regulators. We show that whole-genome and transcriptome sequencing can be achieved within clinically effective timelines, yielding clinically useful and actionable information.
Socioeconomic Status and Lifestyle Behaviours in Cancer Survivors: Smoking and Physical Activity
Authors: Naik H. , Qiu X. , Brown M.C. , Eng L. , Pringle D. , Mahler M. , Hon H. , Tiessen K. , Thai H. , Ho V. , Gonos C. , Charow R. , Pat V. , Irwin M. , Herzog L. , Ho A. , Xu W. , Jones J.M. , Howell D. , Liu G.
Published: December 2016

Purpose: Smoking cessation and increased physical activity (PA) have been linked to better outcomes in cancer survivors. We assessed whether socioeconomic factors influence changes in those behaviours after a cancer diagnosis. Methods: As part of a cross-sectional study, a diverse group of cancer survivors at the Princess Margaret Cancer Centre (Toronto, ON), completed a questionnaire about past and current lifestyle behaviours and perceptions about the importance of those behaviours with respect to their health. The influence of socioeconomic indicators on smoking status and physical inactivity at 1 year before and after diagnosis were assessed using multivariable logistic regression with adjustment for clinico-demographic factors. Results: Of 1222 participants, 1192 completed the smoking component. Of those respondents, 15% smoked before diagnosis, and 43% of those smokers continued to smoke after. The proportion of survivors who continued to smoke increased with lower education level (p = 0.03). Of the 1106 participants answering PA questions, 39% reported being physically inactive before diagnosis, of whom 82% remained inactive afterward. Survivors with a lower education level were most likely to remain inactive after diagnosis (p = 0.003). Lower education level, household income, and occupation were associated with the perception that PA had no effect or could worsen fatigue and quality of life (p ≤ 0.0001). Conclusions: In cancer survivors, education level was a major modifier of smoking and PA behaviours. Lower socioeconomic status was associated with incorrect perceptions about PA. Targeting at-risk survivors by education level should be evaluated as a strategy in cancer survivorship programs.
Chemotherapy in Recurrent Advanced Non-Small-Cell Lung Cancer After Adjuvant Chemotherapy
Authors: Valdes M. , Nicholas G. , Goss G.D. , Wheatley-Price P.
Published: December 2016

Introduction: Despite adjuvant systemic therapy in patients with completely resected non-small-cell lung cancer (NSCLC), many will subsequently relapse. We investigated treatment choices at relapse and assessed the effect of palliative platinum doublet systemic therapy in this population. Methods: With research ethics board approval, we performed a retrospective chart review of all patients with resected NSCLC who received adjuvant systemic therapy from January 2002 until December 2008 at our institution. The primary outcome was the response rate to first-line palliative systemic therapy among patients who relapsed. Results: We identified 176 patients who received adjuvant platinum doublet systemic therapy (82% received cisplatin–vinorelbine). In the 85 patients who relapsed (48%), median time to relapse was 18.5 months (95% confidence interval: 15 months to 21.3 months). Palliative systemic therapy was given in 43 patients. Of those 43 patients, 25 (58%) were re-challenged with platinum doublet systemic therapy, with a response rate of 29% compared with 18% in 18 patients who received other systemic therapy (p = 0.48). We observed a trend toward an increased clinical benefit rate (complete response + partial response + stable disease) in patients who were treated with a platinum doublet (67% vs. 41%, p = 0.12). Median overall survival (OS) from relapse was 15.3 months in patients receiving palliative systemic therapy and 7.8 months in those receiving best supportive care alone. Compared with patients treated with non-platinum regimens, the platinum-treated group experienced longer survival after relapse (18.4 months vs. 9.7 months, p = 0.041). Conclusions: In patients previously treated with adjuvant systemic therapy, re-treatment with platinum doublet chemotherapy upon relapse is feasible. Moreover, compared with patients receiving other first-line systemic therapy, patients receiving platinum doublets experienced higher response rates and significantly longer survival.
Stakeholder Views on Participant Selection for First-in-Human Trials in Cancer Nanomedicine
Authors: Satalkar P. , Elger B.S. , Shaw D.M.
Published: December 2016

Background: Participant selection for first-in-human (FIH) trials involves complex decisions. The trial design makes it unlikely that participants will receive clinically relevant therapeutic benefit, but they are likely to experience risks of various magnitudes and types. The aim of the present paper was to describe and discuss the views of investigators and ethics committee members about the choice of trial participants for FIH trials in cancer nanomedicine. Methods: We drew insights from an exploratory qualitative study involving thematic analysis of 46 in-depth interviews with key stakeholders in Europe and North America involved in FIH nanomedicine trials. The present work draws on subset of 21 interviews with investigators and ethics committee members who have either conducted or reviewed a FIH cancer nanomedicine trial or are planning one. Results: Investigators and ethics committee members are aware of the ethics standards for recruiting patients with end-stage cancer into FIH trials, but they nonetheless question the practice and provide reasons against it. Conclusions: Although it is a standard and ethically accepted practice to enrol patients with end-stage cancer and no treatment options into FIH trials of investigational chemotherapeutic molecules, doing so can threaten the validity and generalizability of the trials, thereby weakening translational research. Another possibility is to stratify and include patients with less advanced disease who demonstrate certain biomarkers or cancer genotypes and who have a disease profile similar to that tested in preclinical studies. The latter approach could be a step toward personalized medical research and targeted drug development. Such a patient selection approach requires multi-stakeholder discussion to reach scientific and ethics consensus.
Effect of Chemotherapy on Health-Related Quality of Life among Early-Stage Ovarian Cancer Survivors: A Study from the Population-Based Profiles Registry
Authors: Bhugwandass C.S. , Pijnenborg J.M.A. , Pijlman B. , Ezendam N.P.M.
Published: December 2016

Background: There is wide variation in the application of adjuvant chemotherapy in early-stage epithelial ovarian cancer. Our aim was to assess differences in health-related quality of life (HRQOL) between patients with early-stage ovarian cancer who did or did not receive chemotherapy as adjuvant treatment. Methods: All patients diagnosed with early-stage ovarian cancer between 2000 and 2010 within the population-based Eindhoven Cancer Registry (n = 191) were enrolled in this study. Patients were requested to complete questionnaires, including the cancer-specific (QLQ-C30) and ovarian cancer-specific (QLQ-OV28) quality of life measures from the European Organisation for Research and Treatment of Cancer. Primary outcome measures were the generic-and cancer-specific domain scores for HRQOL in ovarian cancer survivors. Results: Of the 107 patients (56%) who returned the questionnaires, 57 (53.3%) had received adjuvant chemotherapy and 50 (46.7%) had been treated with surgery alone. Significant differences in HRQOL between those groups were found in the symptom scales for peripheral neuropathy, attitude toward sickness, and financial situation, with worse scores in the chemotherapy group. Conclusions: Results of our study show that patients who receive adjuvant chemotherapy have a significantly worse score for 3 aspects of HRQOL. Efforts should be made to reduce use of adjuvant chemotherapy in early-stage ovarian cancer. Moreover, preventive strategies to improve long-term quality of life for those who need adjuvant chemotherapy should be explored.
Cancer Referral and Treatment Activity 2010–2015: A Population-Based Study from Vancouver Island
Authors: Savage P. , Holloway C. , Lindsay G. , Shubrook K. , Jones C. , Fung M. , Schaff K. , Anderson H. , Nystedt K. , Rauw J.
Published: December 2016

Introduction The years since 2005 have seen major changes in cancer treatment and significant increases in the number of anticancer drugs available. However, there are relatively few published data to reflect how those changes are affecting the activity and workload of oncology services. To explore the effects of those changes, we reviewed the population-based cancer treatment activity on Vancouver Island for the period 2010–2015. Methods Information about new patient referrals, radiation courses, new chemotherapy cycles commenced, total intravenous (IV) chemotherapy treatment visits, and pharmacy activity for oral anticancer drug prescriptions was obtained from BC Cancer Agency databases. Results During the 5-year study period, the Vancouver Island population increased by 2.8% and the number of new referrals to the BC Cancer Agency increased by 17.7%. The overall number of radiation courses increased by 6.1%. In contrast, IV chemotherapy activity increased by 52.1% for new courses commenced and by 62% for total IV chemotherapy attendances. Oral anticancer drug prescriptions rose by 22.9% during the 5-year period. Conclusions Our study documents substantial recent increases in cancer therapy activity in terms of patient referrals and particularly IV chemotherapy and oral anticancer therapy. The data reported here could be of value in planning for future care provision.
Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016
Authors: Bossé D. , Ng T. , Ahmad C. , Alfakeeh A. , Alruzug I. , Biagi J. , Brierley J. , Chaudhury P. , Cleary S. , Colwell B. , Cripps C. , Dawson L.A. , Dorreen M. , Ferland E. , Galiatsatos P. , Girard S. , Gray S. , Halwani F. , Kopek N. , Mahmud A. , Martel G. , Robillard L. , Samson B. , Seal M. , Siddiqui J. , Sideris L. , Snow S. , Thirwell M. , Vickers M. , Goodwin R. , Goel R. , Hsu T. , Tsvetkova E. , Ward B. , Asmis T.
Published: December 2016

The annual Eastern Canadian Gastrointestinal Cancer Consensus Conference 2016 was held in Montreal, Quebec, 5–7 February. Experts in radiation oncology, medical oncology, surgical oncology, and infectious diseases involved in the management of patients with gastrointestinal malignancies participated in presentations and discussion sessions for the purpose of developing the recommendations presented here. This consensus statement addresses multiple topics: (1) Follow-up and survivorship of patients with resected colorectal cancer; (2) Indications for liver metastasectomy; (3) Treatment of oligometastases by stereotactic body radiation therapy; (4) Treatment of borderline resectable and unresectable pancreatic cancer; (5) Transarterial chemoembolization in hepatocellular carcinoma; (6) Infectious complications of antineoplastic agents.
Early Integration of Palliative Care into Standard Oncology Care: Evidence and Overcoming Barriers to Implementation
Authors: Kain D.A. , Eisenhauer E.A.
Published: December 2016

In Canada, widespread discussion of medical aid in dying (http://www.parl.gc.ca/HousePublications/Publication.[...]
Early Palliative Care: Taking Ownership and Creating the Conditions
Authors: Pereira J. , Chasen M.R.
Published: December 2016

The evidence for early integration of palliative care into standard oncology care is growing.[...]
O-Alkylated heavy atom carbohydrate probes for protein X-ray crystallography: Studies towards the synthesis of methyl 2-O-methyl-L-selenofucopyranoside
Authors: Sommer Roman , Hauck Dirk , Varrot Annabelle , Imberty Anne , Künzler Markus , Titz Alexander
Published: December 2016

Selenoglycosides are used as reactive glycosyl donors in the syntheses of oligosaccharides. In addition, such heavy atom analogs of natural glycosides are useful tools for structure determination of their lectin receptors using X-ray crystallography. Some lectins, e.g., members of the tectonin family, only bind to carbohydrate epitopes with O-alkylated ring hydroxy groups. In this context, we report the first synthesis of an O-methylated selenoglycoside, specifically methyl 2-O-methyl-L-selenofucopyranoside, a ligand of the lectin tectonin-2 from the mushroom Laccaria bicolor. The synthetic route required a strategic revision and further optimization due to the intrinsic lability of alkyl selenoglycosides, in particular for the labile fucose. Here, we describe a successful synthetic access to methyl 2-O-methyl-L-selenofucopyranoside in 9 linear steps and 26% overall yield starting from allyl L-fucopyranoside.
Phenotypic and Haplotype Diversity among Tetraploid and Hexaploid Wheat Accessions with Potentially Novel Insect Resistance Genes for Wheat Stem Sawfly
Authors: Cook J. P. , Blake N. K. , Heo H. Y. , Martin J. M. , Weaver D. K. , Talbert L. E.
Published: December 2016

Genetic diversity in breeding programs can be impaired by fixation of alleles derived from a limited number of founder lines. This is demonstrated with the use of a solid‐stem trait derived from the Portuguese landrace ‘S‐615’ over 70 yrs ago that is widely used to resist the wheat stem sawfly (Cephus cinctus Norton, WSS) in North America. The objective of this study was to evaluate haplotype diversity underlying the Qss.msub.3BL quantitative trait locus (QTL) that controls the majority of the S‐615 derived solid‐stem genetic variation using single‐nucleotide polymorphism (SNP) assays in a diverse set of 228 solid‐stem tetraploid and hexaploid wheat accessions originating from areas of the world infested with various species of WSS. Haplotype analysis showed all WSS‐resistant hexaploid wheat varieties in North America, except ‘Conan’, evaluated in this study contain a haplotype associated with the S‐615 solid‐stem allele. In total, 26 haplotypes were identified among the hexaploid and tetraploid accessions at Qss.msub‐3BL. Prevalence of most haplotypes were skewed toward either the hexaploid or tetraploid wheat accessions. The haplotype found in the S‐615‐ hexaploid wheat landrace was not found in the solid‐stem tetraploid landrace accessions evaluated in this study. Haplotype analysis revealed several new haplotypes that have potential to contain novel alleles for solid‐stems at Qss.msub.3BL, which may form the basis for introducing genetic diversity into breeding programs aimed at WSS resistance.
Introgressed Genomic Regions in a Set of Near‐Isogenic Lines of Common Bean Revealed by Genotyping‐by‐Sequencing
Authors: Ferreira Juan José , Murube Ester , Campa Ana
Published: December 2016

Genotyping‐by‐sequencing (GBS) was used to investigate and identify the introgressed genomic regions that corresponded to resistance alleles for anthracnose (Co‐2 and Co‐3), bean common mosaic virus (BCMV), and bean common mosaic necrosis virus (BCMNV, I and bc‐3) in a set of bean near‐isogenic lines (NIL). The GBS analysis provided 12,697 single nucleotide polymorphisms (SNPs) although the densities along the chromosomes were not uniform, and some chromosomal regions, such as centromeric or pericentromeric regions, were less tagged. The backcrossing method resulted in the introgression of genomic regions into specific chromosomes. The number of introgressed region‐tagging SNPs varied between 1 and 13, representing between 0.33 and 6.88% of the bean genome. The changes detected among the recurrent parent and NIL in chromosomal regions are candidate regions that may contain the introgressed genes. By comparing the NIL derived from the same resistance source, it was possible to delimit in chromosomes Pv02, Pv04, Pv06, and Pv11 the genomic regions containing the resistance genes I, Co‐3, bc‐3, and Co‐2. Results allowed verification of the physical positions of the resistance genes and a clearer physical position of the anthracnose resistance genes Co‐2 and Co‐3. Two nonoverlapping regions were delimited in chromosome Pv11 from common regions in NIL with resistance loci mapped to the Co‐2 cluster. Alleles of the loci included within these genomic regions show strong linkage disequilibrium. This knowledge can be used in selection programs involving these regions rich in resistance genes.
DISCOVERY OF BROAD MOLECULAR LINES AND OF SHOCKED MOLECULAR HYDROGEN FROM THE SUPERNOVA REMNANT G357.7+0.3: HHSMT, APEX, SPITZER, AND SOFIA OBSERVATIONS
Authors: Rho J. , Hewitt J. W. , Bieging J. , Reach W. T. , Andersen M. , Güsten R.
Published: December 2016

We report a discovery of shocked gas from the supernova remnant (SNR) G357.7+0.3. Our millimeter and submillimeter observations reveal broad molecular lines of CO(2-1), CO(3-2), CO(4-3), 13CO (2-1), and 13CO (3-2), HCO+, and HCN using the Heinrich Hertz Submillimeter Telescope, the Arizona 12 m Telescope, APEX, and the MOPRA Telescope. The widths of the broad lines are 15–30 km s−1, and the detection of such broad lines is unambiguous, dynamic evidence showing that the SNR G357.7+0.3 is interacting with molecular clouds. The broad lines appear in extended regions (>4.′5 × 5′). We also present the detection of shocked H2 emission in the mid-infrared but lacking ionic lines using Spitzer/IRS observations to map a few-arcminute area. The H2 excitation diagram shows a best fit with a two-temperature local thermal equilibrium model with the temperatures of ∼200 and 660 K. We observed [C ii] at 158 μm and high-J CO(11-10) with the German Receiver for Astronomy at Terahertz Frequencies (GREAT) on the Stratospheric Observatory for Infrared Astronomy. The GREAT spectrum of [C ii], a 3σ detection, shows a broad line profile with a width of 15.7 km−1 that is similar to those of broad CO molecular lines. The line width of [C ii] implies that ionic lines can come from a low-velocity C-shock. Comparison of H2 emission with shock models shows that a combination of two C-shock models is favored over a combination of C- and J-shocks or a single shock. We estimate the CO density, column density, and temperature using a RADEX model. The best-fit model with n(H2) = 1.7 × 104 cm−3, N(CO) = 5.6 × 1016 cm−2, and T = 75 K can reproduce the observed millimeter CO brightnesses.
The first data on the freshwater microcrustaceans of Shokalsky Island (Russian Arctic)
Authors: Novichkova Anna
Published: December 2016

Information on freshwater invertebrates of the Russian Arctic is very scarce, especially concerning insular biota. The species composition of microcrustaceans (Cladocera, Copepoda) of many arctic islands is still unknown and have never been explored. Here we report the results of the first investigation of the zooplankton of the Shokalsky Island (Yamalo­Nenets Autonomous Okrug, Russia).

Information on freshwater invertebrates of the Russian Arctic is very scarce, especially concerning insular biota. The species composition of microcrustaceans (Cladocera, Copepoda) of many arctic islands is still unknown and have never been explored. Here we report the results of the first investigation of the zooplankton of the Shokalsky Island (Yamalo­Nenets Autonomous Okrug, Russia).

The new records reported here are novel for the region and significantly expand the knowledge of the high­-latitude aquatic biota. We studied the species composition of Cladocera and Copepoda of 21 freshwater habitats located on the south­western part of Shokalsky Island. We found 15 species of microcrustaceans in total and all of them are reported for the first time here. Also, the obtained data expand the existing ranges of distribution of some species and report several new taxa for the whole Yamalo­Nenets region of Russia.
Tableau de Quesnay et Tableau de Leontief
Authors: Le Masne Pierre
Published: December 2016

L’article compare le Tableau de Quesnay et le Tableau de Leontief en explorant les voies de passage du premier au second. Les concepts économiques de Quesnay sont examinés par rapport à la comptabilité nationale moderne. Une transposition des comptes de la Philosophie rurale en un Tableau d’Entrées-Sorties s’avère possible, sous deux formes différentes, dont l’une correspond au Tableau de Quesnay. En dépit de cette transposition comptable, le modèle de Leontief reste éloigné des problématiques de Quesnay, plus larges que celles de Leontief. Codes JEL:  B110, N5
Georg von Charasoff and Anticipation of von Mises Iteration in Economic Analysis
Authors: Mori Kenji
Published: December 2016

Dans son ouvrage principal, Das System des Marxismus. Darstellung und Kritik 1910, Georg von Charasoff a critiqué et reconstruit la théorie des prix de Marx et, ce faisant, a anticipé la plupart des résultats analytiques qui allaient être obtenus plus tard à l’occasion de la « controverse sur la transformation ». Cependant, sa contribution concerne un champ plus étendu que la seule théorie marxienne. Cet article vise à montrer comment l’analyse économique linéaire de Charasoff, et en particulier sa théorie de l’ «Urkapital» (capital originel), du prix de production et de la valeur-travail, a anticipé le développement de la théorie des matrices de Richard von Mises et Hilda Pollaczek-Geiringer (1929). Ils ont élaboré des procédures de calcul des valeurs propres et des vecteurs propres (la «Power Method» ou «von Mises Iteration») et proposé, en outre, une méthode itérative pour résoudre des systèmes d’équations linéaires non homogènes.
La foi et l’économie : Maurice Potron, précurseur de l’analyse input-output
Authors: Bidard Christian , Erreygers Guido
Published: December 2016

Maurice Potron (1872-1942) est un mathématicien français qui, dès 1911, conçoit un modèle économique où l’analyse de la production est fondée sur la construction d’un tableau analogue à celui des échanges interindustriels imaginé plus tard par Leontief. Potron définit la notion de régime satisfaisant et établit un résultat d’existence en utilisant le théorème de Perron-Frobenius, bien avant que celui-ci ne soit connu des économistes. Il énonce aussi le premier théorème explicite de dualité. Nous examinons ici la vie de Potron, qui était jésuite, et soulignons l’inspiration religieuse de son modèle. Un rôle particulier dans cette analyse revient à la doctrine sociale de l’Église, qui est renouvelée par l’encyclique Rerum novarum et au service de laquelle lui-même et sa famille se sont fortement engagés. Nous expliquons aussi pourquoi ce travail de pionnier est longtemps passé inaperçu. Codes JEL :  B31, C62, C67
Maurice Potron, Ragnar Frisch and Potron’s economic model, followed by an unpublished letter from Maurice Potron to Ragnar Frisch
Authors: Erreygers Guido , Bidard Christian
Published: December 2016

Dans cet article, nous explorons les liens entre Maurice Potron et Ragnar Frisch. On savait déjà que Frisch a exercé, à travers Gibrat, une influence indirecte sur les recherches économiques tardives de Potron. Des documents découverts récemment, et publiés ici pour la première fois, montrent qu’il a eu aussi une influence directe. Il est difficile d’établir dans quelle mesure et à quel niveau l’effet Frisch a joué. Nous présentons les caractéristiques de base du modèle de Potron et soulignons qu’elles sont restées sensiblement les mêmes des premiers aux derniers écrits. Bien que le lien avec Frisch n’ait pas conduit à des modifications majeures du modèle de Potron, il est possible que ce contact ait convaincu Potron de l’utilité de reprendre ses recherches économiques dans la seconde moitié des années 1930 et de tenter d’attirer l’attention de la communauté des économistes. L’épisode Frisch a peut-être donné à Potron la confiance nécessaire pour organiser une série de six conférences à l’Institut Catholique de Paris en 1937, malgré la résistance de ses supérieurs.
Price consistency in the Leontief model
Authors: de Mesnard Louis
Published: December 2016

Le modèle de Leontief utilise en fait deux périodes, les périodes de base et courantes. Le modèle est résolu avec les indices de prix courants et les coefficients techniques de base. Le modèle physique correspondant est monopériodique: il est résolu avec les prix courants et les coefficients courants. Le modèle de Leontief n’est pas cohérent – les deux modèles divergent généralement – à moins que la matrice interindustrielle des quantités directes et indirectes de travail ne soit stable dans le temps. Cela implique que les coefficients de travail verticalement intégrés sont stables. Cette hypothèse est satisfaite lorsque les coefficients de production physiques et les coefficients de travail physiques sont stables dans le temps, deux hypothèses très fortes.
Évolution des politiques sociales envers les personnes en situation de handicap
Authors: Sautegeau Armelle , Garrigues Céline , Fourroux Maryse
Published: December 2016

Ce texte présente l’évolution des politiques publiques relatives au handicap, essentiellement à partir de la loi de 1975. Il commente l’important arsenal juridique et administratif mis en place en vue de permettre une meilleure reconnaissance pour une intégration des personnes handicapées. Si le droit à compensation est affirmé par la loi de 2005, son effectivité reste plus difficile. Ce sont tout à la fois les structures, les moyens et les représentations qui sont en cause dans ce trop lent cheminement vers l’intégration.
Les troubles associés à la déficience intellectuelle
Authors: Boulanger Jacques
Published: December 2016

Si l’événement premier constitutif de la déficience intellectuelle est biologique, celle-ci devient, dès la gestation et la petite enfance, un état hétérogène aux incidences multiples, où le génétique s’imbrique au mimétique, le phénotype comportemental aux identifications, de sorte qu’ensuite, démêler la part de l’inné et de l’acquis dans le comportement de l’enfant devient illusoire. Pour le clinicien, l’enquête génétique, essentielle, ne suffit pas. Il reste à évaluer l’état du fonctionnement mental, avec sa double composante cognitive et affective. Dans cette évaluation, dresser un inventaire précis des troubles associés est devenu un enjeu stratégique dans l’élaboration d’un projet individuel d’accompagnement.
Les enjeux d’une scolarité portée par les IME
Authors: Detchart Frédéric
Published: December 2016

La loi pour la refondation de l’école de la République de 2013 consacre le principe d’éducation inclusive pour tous les enfants en âge d’être scolarisés. L’École s’engage à scolariser l’élève à besoins éducatifs particuliers, « au plus proche de son lieu de vie et avec les adaptations pédagogiques et les compensations nécessaires à la réalisation de son projet de vie ». L’école inclusive devient alors une des réponses à la demande pressante des associations de parents d’enfants handicapés, en particulier celles favorables à la désinstitutionnalisation. Au-delà de la scolarisation, c’est aussi l’avenir professionnel qui est désormais envisagé et pris en considération. Cet article analyse concrètement comment le rectorat de Midi-Pyrénées a mis en place un ensemble de réponses pédagogiques, techniques, institutionnelles pour répondre à ces ambitions qui impactent le parcours de formation proposé en ime .
Des enfants si différents… dans un même IME
Authors: Grandchamp Gilles
Published: December 2016

Les enfants accueillis dans les ime aujourd’hui présentent des profils cliniques plus hétérogènes et plus sévères. Il convient de s’interroger sur ce phénomène, sur ses origines et sur les conséquences sur les pratiques professionnelles et les institutions. De nouveaux modes de prise en charge des jeunes doivent être proposés au plus près des besoins de chaque enfant. À défaut, les ime pourraient devenir des établissements inadaptés et leur avenir être remis en cause.
Quelle formation initiale et continue pour les professionnels éducatifs travaillant en IME ?
Authors: Heim Philippe
Published: December 2016

La fonction éducative au sein des ime ouvre à toute une série de questionnements, tant sur la transformation du secteur que sur les acteurs de ces institutions, sur les modèles de la formation professionnelle et les formes d’engagement professionnel. Il est question aujourd’hui de formation tout au long de la vie et les professionnels dits de terrain ont une part très importante dans la qualification des nouveaux venus. Apprendre à se définir comme professionnel implique un mode de socialisation fort et les ime ne peuvent être considérés comme des structures stables et homogènes.
Insertion
Authors: Granereau Sarah
Published: December 2016

Que veut dire « insertion sociale et professionnelle en imp ro » ? Il est difficile de parler de handicap mental ou de handicap psychique quand la cause n’est pas génétique mais semble le résultat de trop d’angoisses ou de trop d’insécurité pour grandir sereinement. La prise en charge des jeunes déficients intellectuels, leur formation, leur insertion dans le monde adulte restent problématiques tant pour les professionnels que pour les familles. L’insertion n’est pas seulement une entrée dans le monde du travail pour les jeunes adultes mais elle est aussi et surtout une bataille pour les professionnels qui souhaitent que leurs actions aient du sens en permettant aux jeunes adultes de se revendiquer citoyens adultes informés et formés au mieux.