bluuebunny/crossref_metadata_2025 huggingface dataset:
ATP bioluminescence rapid detection of total viable count in soy sauce
Authors: Yan Shou‐Lei , Miao Su‐Na , Deng Shao‐Ya , Zou Min‐Juan , Zhong Fo‐Sheng , Huang Wen‐Biao , Pan Si‐Yi , Wang Qing‐Zhang
Published: June 2011

The adenosine triphosphate (ATP) bioluminescence rapid determination method may be useful for enumerating the total viable count (TVC) in soy sauce, as it has been previously used in food and beverages for sanitation with good precision. However, many factors interfere with the correlation between total aerobic plate counts and ATP bioluminescence. This study investigated these interfering factors, including ingredients of soy sauce and bacteria at different physiological stages. Using the ATP bioluminescence method, TVC was obtained within 4 h, compared to 48 h required for the conventional aerobic plate count (APC) method. Our results also indicated a high correlation coefficient (r = 0.90) between total aerobic plate counts and ATP bioluminescence after filtration and resuscitation with special medium. The limit of quantification of the novel detection method is 100 CFU/mL; there is a good linear correlation between the bioluminescence intensity and TVC in soy sauce in the range 1 × 102–3 × 104 CFU/mL and even wider. The method employed a luminescence recorder (Tristar LB‐941) and 96‐well plates and could analyse 50–100 samples simultaneously at low cost. In this study, we evaluated and eliminated the interfering factors and made the ATP bioluminescence rapid method available for enumerating TVC in soy sauce. Copyright © 2011 John Wiley & Sons, Ltd.
Toxizität der Dioxine. Ultragifte oder Panikmache?
Authors: Schrenk Dieter
Published: June 2011

Dioxine sind chlororganische Verbindungen mit hoher Persistenz in der Umwelt. Sie finden sich in der Nahrung, im Blut und der Muttemilch. Zu den toxischen Wirkungen an Versuchstieren zählen, nach entprechender Dosierung, Störungen des Immunsystems, der hormonellen Steuerung, Entwicklungsstörungen und Tumoren. Beim Menschen ist v.a. eine schwer heilende Form der Akne, die so genannte Chlorakne, beschrieben. Die Toxizität der Dioxine beruht auf der Aktivierung des Dioxin‐ oder Arylhydrocarbon‐Rezeptors, dessen eigentliche biologische Funktion noch ungeklärt ist.
Neues zur Wiederentdeckung der Mendelschen Regeln
Authors: Simunek Michal , Hoßfeld Uwe
Published: June 2011

Angesichts neuer Archivfunde muss die frühe Geschichte der Genetik, insbesondere die tradierte Geschichte von der “Wiederentdeckung” der Vererbungsgesetze Mendels um einige Facetten ergänzt beziehungsweise erweitert werden.
Nahrungnetze: eine Zunahme an Seetang – und die Folgen
Authors: Sander Johannes
Published: June 2011

Ökosysteme beherbergen zahlreiche Spezies, die auf vielfältige Weise in Wechselwirkung treten. Diese Wechselwirkungen hängen von der räumlichen und zeitlichen Verteilung der Organismen ab und können durch Einflüsse der Umgebung massiv beeinflusst werden. Ein Beispiel hierfür liefern Änderungen bei der Menge an angeschwemmtem Seetang auf karibischen Inseln.
A writing‐intensive, methods‐based laboratory course for undergraduates
Authors: Colabroy Keri L.
Published: June 2011

Engaging undergraduate students in designing and executing original research should not only be accompanied by technique training but also intentional instruction in the critical analysis and writing of scientific literature. The course described here takes a rigorous approach to scientific reading and writing using primary literature as the model while simultaneously integrating laboratory instruction on basic enzyme purification and characterization, followed by 6 weeks of laboratory dedicated to student‐designed original research projects. In the preparation and execution of their original projects, students engage in analysis of the primary literature, proposal writing, peer review, manuscript preparation, and oral presentation. The result is a comprehensive and challenging course that teaches third‐ and fourth‐year undergraduates what it means to “think and work like a scientist.” Biochemistry and Molecular Biology Education Vol. 39, No. 3, pp. 196–203, 2011
HarmoSim: A tool for harmonic distortion simulation and assessment of nonlinear loads
Authors: Baptista J. , Morais R. , Valente A. , Soares S. , Candeias M. , Reis M.J.C.S.
Published: June 2011

Electrical power quality (PQ) is a crucial competitive and developing factor to all economic activities. The economic impact resulting from a bad PQ would be drastic on all consumers. Computers, uninterruptible and switched power supplies (UPS), and fluorescent lamps/tubes are examples of nonlinear loads that have the consumption of a nonsinusoidal current, which cause disturbances in the power supply system (that may be severe or not). This study discusses residential generic power circuitry analysis and simulation, under nonlinear loads, in connection with undergraduate electrical engineering education. It briefly reviews some of the basic techniques, and presents a software tool that has been found to be very useful in the context. The tool has an easy‐to‐use, friendly interface, and can be used to teach design techniques or as a laboratory support to study the applicability of known methods to real situations. The students can perform simulations with their own data on Microsoft™ Windows®‐based platforms. © 2011 Wiley Periodicals, Inc. Comput Appl Eng Educ 22:340–348, 2014; View this article online at wileyonlinelibrary.com/journal/cae; DOI 10.1002/cae.20559
Advanced Electron Microscopy of Metal–Support Interactions in Supported Metal Catalysts
Authors: Liu Jingyue (Jimmy)
Published: June 2011

Electron microscopy and its associated techniques have contributed significantly to the characterization of heterogeneous catalysts, especially supported metal catalysts, and can provide nano‐ or atomic‐scale information on the structure, morphology, composition, and electronic state of the area of interest. With the recent advancement in aberration corrections to achieve an image resolution below 0.1 nm and the rapid development of in situ techniques, advanced electron microscopy is poised to probe fundamental questions of heterogeneous catalysis and catalysts. Understanding the nature of metal–support interactions becomes critical if we want to achieve the goal of designing and fabricating nanoarchitectured catalysts with desired performances. To reliably probe the fundamental mechanisms of charge transfer, which is the core of catalysis, between individual nanoscale components and under a realistic gas environment and temperature is still a formidable challenge. This Review discusses the recent contribution of advanced electron microscopy to the study of metal–support interactions, as well as the challenges and opportunities of applying aberration‐corrected electron microscopy techniques to the investigation of atomic‐scale structures of complex heterogeneous catalysts.
Rational Design of Zinc–Organic Coordination Polymers Directed by N‐Donor Co‐ligands
Authors: Wang Sujing , Xiong Shunshun , Wang Zhiyong , Du Jiangfeng
Published: June 2011

A family of ZnII‐based metal–organic coordination polymers (MOCPs) [Zn(L)(imid)2] (1), [Zn(L)(2,2′‐bpy)] (2), [Zn2(L)2(Py)3] (3), [Zn(L)(DPP)]⋅DMF (4), [Zn(L)(DPEA)] (5), [Zn2(L)2(4,4′‐bpy)] (6), [Zn(L)(3,4′‐DPEE)]⋅DMF (7), and [Zn3(L)3(3,4′‐DPEE)2]⋅DMF (8) (L=dithieno[3,2‐b:2′,3′‐e]benzene‐2,6‐dicarboxylic acid, imid=imidazole, bpy=bipyridine, Py=pyridine, DPP=1,3‐di(pyridin‐4‐yl)propane, DPEA=1,2‐di(pyridin‐4‐yl)ethane, and DPEE=(E)‐3,4′‐(ethene‐1,2‐diyl)dipyridine) have been rationally designed and generated in the solvothermal reaction systems of the new conjugated thiophene derivative L, Zn(ClO4)2⋅6 H2O, and seven different aromatic N‐donor co‐ligands separately. These N‐donor compounds were carefully selected and employed in the crystal preparation of the eight MOCPs as structure‐directing co‐ligands owing to their structural specialties and habitual coordination fashions. Among these MOCPs, compounds 1–3 are 1D polymers with different chain structures. Compounds 4, 7, and 8 are 2D structures, in which 4 has two sets of twofold interpenetrating layers, whereas 7 and 8 are both built from three independent sheets. Compounds 5 and 6 are 3D frameworks, in which 5 exhibits a fivefold interpenetrating diamondoid network, whereas 6 shows a typical twofold interpenetrating pillared layer structure with nanoscale channels. The photoluminescent properties of these MOCPs, including excitation, emission, and radiactive lifetime, have also been investigated to help us tentatively understand their structure–property relationships.
“Deconvoluted Fullerene” Derivatives: Synthesis and Characterization
Authors: Brunetti Fulvio G. , Varotto Alessandro , Batara Nicolas A. , Wudl Fred
Published: June 2011

We have designed the synthesis of “deconvoluted fullerene” derivatives that present an ordered pattern of hexagons and pentagons in the backbone of the molecule. We not only mimicked the fullerene structure in dihedral planes, but also preserved its electron accepting behavior and enlarged its optical absorption. Moreover, very preliminary photoluminescence (PL) quenching experiments also confirmed the potentiality of these materials as acceptors in the field of organic photovoltaics (OPV)s. A brief discussion of the surface morphology, based on AFM analysis, is also presented.
ChemInform Abstract: Structure and 31P NMR Spectroscopy of a New Phosphate, Na8Ca1.5Mg12.5 (PO4)12.
Authors: Jerbi Hasna , Hidouri Mourad , Rzeigui Mohamed , Ben Amara Mongi
Published: June 2011

The new title compound is synthesized by reaction of NH4H2PO4, Na2CO3, CaCO3, and MgCO3 in a flux of Na2MoO4 (Pt crucible, 673 K for 24 h, 873 K for 12 h, and 1273 K for 2 h).
ChemInform Abstract: Complete Titanium Substitution by Boron in a Tetragonal Prism: Exploring the Complex Boride Series Ti3‐xRu5‐yIryB2+x (0 ≤ x ≤ 1 and 1 < y < 3) by Experiment and Theory.
Authors: Fokwa Boniface P. T. , Hermus Martin
Published: June 2011

Single crystals of Ti3Ru2.9Ir2.1B2, Ti2.63Ru3.4Ir1.6B2.37, Ti2.27Ru2.5Ir2.5B2.73, and Ti2Ru2.8Ir2.2B3 are prepared by arc melting of the elements (copper crucible, Ar atmosphere).
ChemInform Abstract: Microwave‐Assisted Solvothermal Synthesis and Characterization of Metastable LiFe1‐x(VO)xPO4 Cathodes.
Authors: Harrison Katharine L. , Manthiram Arumugam
Published: June 2011

The title compounds (0 ≤ x ≤ 0.25 and x = 1) are synthesized from a stoichiometric mixture of LiOH, Fe(OAc)2, VO(OiPr)3, and H3PO4 in tetraethylene glycol (microwaves, 260 °C, 5—10 min).
ChemInform Abstract: Ammonium Octahydrotriborate (NH4B3H8): New Synthesis, Structure, and Hydrolytic Hydrogen Release.
Authors: Huang Zhenguo , Chen Xuenian , Yisgedu Teshome , Meyers Edward A. , Shore Sheldon G. , Zhao Ji‐Cheng
Published: June 2011

The title compound is prepared by a metathesis reaction between unsolvated NaB3H8 and NH4Cl in liquid ammonia at ‐78 °C (30 min, 95% yield).
ChemInform Abstract: Efficient One‐to‐One Coupling of Easily Available 1,3‐Dienes with Carbon Dioxide.
Authors: Takaya Jun , Sasano Kota , Iwasawa Nobuharu
Published: June 2011

The reaction is efficiently catalyzed by the PSiP‐pincer‐type palladium catalyst and proceeds stereoselectively even when isomeric mixtures are used as substrates.
ChemInform Abstract: Highly Chemo‐ and Regioselective Transfer Reduction of Aromatic Nitro Compounds Using Ammonium Formate Catalyzed by Supported Gold Nanoparticles.
Authors: Lou Xia‐Bing , He Lin , Qian Yue , Liu Yong‐Mei , Cao Yong , Fan Kang‐Nian
Published: June 2011

Transfer hydrogenation of aromatic nitro compounds (I) proceeds smoothly in the system ammonium formate—TiO2‐supported Au(I) particles to give the corresponding amines (II).
ChemInform Abstract: General and Highly α‐Regioselective Zinc‐Mediated Prenylation of Aldehydes and Ketones.
Authors: Zhao Li‐Ming , Jin Hai‐Shan , Wan Li‐Jing , Zhang Li‐Ming
Published: June 2011

Treatment of aldehydes and ketones with prenyl bromide under conditions A) allows facile, efficient, and general access to α‐prenylated alcohols.
ChemInform Abstract: Contemporaneous Dual Catalysis by Coupling Highly Transient Nucleophilic and Electrophilic Intermediates Generated in situ.
Authors: Trost Barry M. , Luan Xinjun
Published: June 2011

α‐Allylated α,β‐unsaturated ketones are prepared from allylic carbonates and propargyl alcohols in the presence of an optimized ratio of a vanadium and a palladium catalyst.
ChemInform Abstract: New Synthetic Strategy for High‐Enantiopurity N‐Protected α‐Amino Ketones and Their Derivatives by Asymmetric Hydrogenation.
Authors: Sun Tian , Hou Guohua , Ma Miaofeng , Zhang Xumu
Published: June 2011

The Rh—DuanPhos catalyzed asymmetric hydrogenation of α‐amino‐α‐methylene ketones (I) and (IV) provides a novel efficient access towards enantioenriched α‐amino ketones (II) and (V), important precursors of amphetamine synthesis.
ChemInform Abstract: Highly Efficient Redox Isomerization of Allylic Alcohols and Transfer Hydrogenation of Ketones and Aldehydes Catalyzed by Ruthenium Complexes.
Authors: Liu Pei Nian , Ju Kun Dong , Lau Chak Po
Published: June 2011

A Ru(II)—dichlorobipyridine complex (Ia) efficiently catalyzes the redox isomerization of terminal and internal allylic alcohols to give the corresponding ketones, e.g. (III), (V) or (VII), in high to excellent conversion.
ChemInform Abstract: Copper(I)‐Mediated Cyanation of Boronic Acids.
Authors: Zhang Guoying , Zhang Lingli , Hu Maolin , Cheng Jiang
Published: June 2011

A wide range of aryl‐ and alkenylboronic acids (I), (V) and esters like (VII) smoothly undergo cyanation with copper(I) cyanide.
ChemInform Abstract: Rhodium(II)‐Catalyzed Cross‐Coupling of Diazo Compounds.
Authors: Hansen Joern H. , Parr Brendan T. , Pelphrey Philip , Jin Quihui , Autschbach Jochen , Davies Huw M. L.
Published: June 2011

Trisubstituted alkenes are efficiently synthesized by a selective cross‐coupling.
ChemInform Abstract: Silica Supported Perchloric Acid: A Convenient and Environmentally Friendly Catalyst for the One‐Pot Multicomponent Synthesis of β‐Acetamido Ketones.
Authors: Nasr‐Esfahani Masoud , Montazerozohori Morteza , Gholampour Tahere
Published: June 2011

A modified Dakin‐West condensation is promoted by silica‐supported perchloric acid as an inexpensive and recyclable catalyst.
ChemInform Abstract: Rh‐Catalyzed Carbonylation of Arylzinc Compounds Yielding Symmetrical Diaryl Ketones by the Assistance of Oxidizing Agents.
Authors: Kobayashi Kana , Nishimura Yugo , Gao Fuxing , Gotoh Kazuma , Nishihara Yasushi , Takagi Kentaro
Published: June 2011

It provides a highly efficient method to prepare symmetrical diaryl ketones.
ChemInform Abstract: The Direct Asymmetric Vinylogous Aldol Reaction of Furanones with α‐Ketoesters: Access to Chiral γ‐Butenolides and Glycerol Derivatives.
Authors: Luo Jie , Wang Haifei , Han Xiao , Xu Li‐Wen , Kwiatkowski Jacek , Huang Kuo‐Wei , Lu Yixin
Published: June 2011

Various γ‐butenolides (III) are prepared in the presence of a tryptophan‐derived bifunctional catalyst.
ChemInform Abstract: Carbon‐Based Solid Acid as an Efficient and Reusable Catalyst for One‐Pot Synthesis of Tetrasubstituted Imidazoles under Solvent‐Free Conditions.
Authors: Tavakoli‐Hoseini Niloofar , Davoodnia Abolghasem
Published: June 2011

A new application for carbon‐based solid acid catalysts in organic synthesis is described.
ChemInform Abstract: Guanidine Organocatalyst for the Asymmetric Mannich‐Type Reaction Between α‐Isothiocyanato Imide and Sulfonyl Imines.
Authors: Chen Xiaohong , Dong Shunxi , Qiao Zhen , Zhu Yin , Xie Mingsheng , Lin Lili , Liu Xiaohua , Feng Xiaoming
Published: June 2011

The catalyst in combination with p‐cyanobenzoic acid affords thioxo‐1‐tosylimidazolidine derivatives with high yields and stereoselectivities.
ChemInform Abstract: A Novel Multicomponent Approach to the Synthesis of 1,3‐Thiazolidine‐2‐thiones.
Authors: Alizadeh Abdolali , Zohreh Nasrin , Sabahnoo Hamideh , Noaparast Zohreh
Published: June 2011

A variety of the target compounds is prepared as the E/Z‐mixtures with moderate selectivities.
ChemInform Abstract: A Facile, One‐Pot, Green Synthesis of Polysubstituted 4H‐Pyrans via Piperidine‐Catalyzed Three‐Component Condensation in Aqueous Medium.
Authors: Lu Guo‐Ping , Cai Chun
Published: June 2011

The efficient presented method for the synthesis of the title compounds can be easily applied for large‐scale reactions.
ChemInform Abstract: Synthesis and Antimicrobial Activity of Novel 2‐(Aryl)‐3‐ [5‐(2‐oxo‐2H‐3‐chromenyl)‐1,3‐oxazol‐2‐yl]‐1,3‐thiazolan‐4‐ones.
Authors: Reddy Ch. Sanjeeva , Devi M. Vani , Kumar G. Rajesh , Rao L. Sanjeeva , Nagaraj A.
Published: June 2011

The title compounds (VI) are tested for their antibacterial activity against the Gram‐positive bacteria B.
ChemInform Abstract: Efficient Chemoselective Alkylation of Quinoline 2,4‐Diol Derivatives in Water.
Authors: Ahmed Nafees , Brahmbhatt Keyur G. , Singh Inder P. , Bhutani Kamlesh K.
Published: June 2011

With a view to developing good anti‐HIV agents the simple and environmentally friendly synthesis of the compounds (III) including an easy work‐up is presented.
ChemInform Abstract: Evaluation of 1‐Arylpiperazine Derivative of Hydroxybenzamides as 5‐HT1A and 5‐HT7 Serotonin Receptor Ligands: An Experimental and Molecular Modeling Approach.
Authors: Kowalski Piotr , Jaskowska Jolanta , Bojarski Andrzej J. , Duszynska Beata , Bucki Adam , Kolaczkowski Marcin
Published: June 2011

The compounds (Ia), (IIb), and (IIc) are 5‐HT1A receptor ligands with nanomolar affinity (Ki = 7, 4 and 3 nM, respectively) and reasonable selectivity for 5‐HT1A receptors.
ChemInform Abstract: Metallofullerenes
Authors: Shinohara Hisanori , Saito Yahachi
Published: June 2011

Review: 295 refs.
ChemInform Abstract: Acanthopanax senticosus: Review of Botany, Chemistry and Pharmacology
Authors: Huang LinZhang , Zhao HongFang , Huang BaoKang , Zheng ChengJian , Peng Wei , Qin LuPing
Published: June 2011

Review: 98 refs.
ChemInform Abstract: Sitagliptin Manufacture: A Compelling Tale of Green Chemistry, Process Intensification, and Industrial Asymmetric Catalysis
Authors: Desai Aman A.
Published: June 2011

Review: 18 refs.
ChemInform Abstract: Chemical Transformations Within the Paramagnetic World Investigated by Photo‐CIDNP
Authors: Goez Martin
Published: June 2011

Review: 34 refs.
ChemInform Abstract: Highly Efficient Palladium‐Catalyzed Arsination on the Way to Arsine Ligands
Authors: Martin Sandra E.
Published: June 2011

Review: 36 refs.
ChemInform Abstract: Multifunctional Hybrids by Combining Ordered Mesoporous Materials and Macromolecular Building Blocks
Authors: Soler‐Illia Galo J. A. A. , Azzaroni Omar
Published: June 2011

Review: ca. 250 refs.
ChemInform Abstract: Hydrogels with Cyclodextrins as Highly Versatile Drug Delivery Systems
Authors: Alvarez‐Lorenzo Carmen , dos Santos Fernando Rosa , Sosnik Alejandro , Torres‐Labandeira Juan J. , Concheiro Angel
Published: June 2011

Review: 189 refs.
ChemInform Abstract: Dextran—Doxorubicin/Chitosan Nanoparticles for Solid Tumor Therapy
Authors: Bisht Savita , Maitra Amarnath
Published: June 2011

Review: 71 refs.
ChemInform Abstract: Oxygen‐17 NMR Spectroscopy: Basic Principles and Applications. Part 1.
Authors: Gerothanassis Ioannis P.
Published: June 2011

Review: 1189 refs.
ChemInform Abstract: Direct Observation of Change in Crystal Structures During Solid‐State Reactions of 1,3‐Diene Compounds
Authors: Matsumoto Akikazu
Published: June 2011

Review: 99 refs.
ChemInform Abstract: Unsymmetrical 1,1′‐Bidentate Ferrocenyl Ligands
Authors: You Shu‐Li
Published: June 2011

Review: 118 refs.
ChemInform Abstract: Structure and Thermodynamic Properties of the NaMgH3 Perovskite: A Comprehensive Study.
Authors: Baricco Marcello , et al. et al.
Published: June 2011

Structural and thermodynamic properties of NaMgH3 are characterized by synchrotron XRD, high pressure DSC, pressure‐composition isotherms, IR spectroscopy, and DFT calculations.
ChemInform Abstract: Aryne Click Chemistry: Synthesis of Oxadisilole Fused Benzotriazoles or Naphthotriazoles from Arynes and Azides.
Authors: Lin Yibei , Chen Yali , Ma Xuyan , Xu Di , Cao Weiguo , Chen Jie
Published: June 2011

Arynes generated in situ from oxadisiloles (I) or (IV) undergo a 1,3‐dipolar cycloaddition reaction with benzyl or aryl azides to give the title fused triazoles under very mild conditions.
ChemInform Abstract: Palladium‐Catalyzed Reaction of Olefins with PhI(OAc)2—TBAB System: An Efficient and Highly Selective Bisfunctionalization Strategy.
Authors: Yu Lei , Ren Lingfeng , Yi Rong , Wu Yulan , Chen Tian , Guo Rong
Published: June 2011

The reaction allows the concurrent and regioselective introduction of oxygen and bromide substituents.
ChemInform Abstract: Gold‐Nanoparticle‐Catalyzed Synthesis of Propargylamines: The Traditional A3‐Multicomponent Reaction Performed as a Two‐Step Flow Process.
Authors: Abahmane Lahbib , Koehler J. Michael , Gross G. Alexander
Published: June 2011

The reaction of aldehydes, amines and phenylacetylene is performed under flow chemistry conditions using two heterogeneous catalyst systems to afford propargylamines mostly in high yields.
ChemInform Abstract: Microwave‐Assisted Rapid and Efficient Reduction of Aromatic Nitro Compounds to Amines with Propan‐2‐ol over Nanosized Perovskite‐Type SmFeO3 Powder as a New Recyclable Heterogeneous Catalyst.
Authors: Farhadi Saeid , Siadatnasab Firouzeh , Kazem Maryam
Published: June 2011

The reaction can also be conducted under conventional heating conditions resulting in similar yields but with prolonged reaction times.
ChemInform Abstract: Gold‐Catalyzed Direct Amination of Arenes with Azodicarboxylates.
Authors: Gu Liuqun , Neo Boon Siong , Zhang Yugen
Published: June 2011

Many functional groups and sterically hindered arenes are tolerated.
ChemInform Abstract: Helical Chiral 2,2′‐Bipyridine N‐Monoxides as Catalysts in the Enantioselective Propargylation of Aldehydes with Allenyltrichlorosilane.
Authors: Chen Jinshui , Captain Burjor , Takenaka Norito
Published: June 2011

A wide range of aromatic aldehydes and an aliphatic one react with allenyltrichlorosilane to afford propargylic alcohols with high yields and enantioselectivities.
ChemInform Abstract: Enhanced anti‐Diastereo‐ and Enantioselectivity in Alcohol‐Mediated Carbonyl Crotylation Using an Isolable Single Component Iridium Catalyst.
Authors: Gao Xin , Townsend Ian A. , Krische Michael J.
Published: June 2011

In the presence of the preformed catalyst, aldehydes and alcohols undergo crotylation with enhanced levels of diastereo‐ and enantioselectivity.
ChemInform Abstract: Enantio‐ and Diastereoselective Synthesis of (E)‐1,5‐syn‐Diols: Application to the Synthesis of the C(23)—C(40) Fragment of Tetrafibricin.
Authors: Kister Jeremy , Nuhant Philippe , Lira Ricardo , Sorg Achim , Roush William R.
Published: June 2011

Chiral Soderquist borane is used to prepare various chiral diols in a one‐pot three‐step reaction of allenyl trifluoroborate (I) with two different aldehydes.
ChemInform Abstract: A Facile Process for the Asymmetric Synthesis of β‐Trifluoromethylated β‐Amino Ketones via Addition of Ketone Enolates to Sulfinylimine.
Authors: Mei Haibo , Xiong Yiwen , Han Jianlin , Pan Yi
Published: June 2011

Title addition reaction proceeds with good yields and moderate to excellent diastereoselectivities, even on large scale preparation.
ChemInform Abstract: An Efficient and Recyclable Heterogeneous Palladium Catalyst Utilizing Naturally Abundant Pearl Shell Waste.
Authors: Zeng Minfeng , Du Yijun , Qi Chenze , Zuo Shufeng , Li Xiudong , Shao Linjun , Zhang Xian‐Man
Published: June 2011

Pd on pearl shell powder is an efficient and recyclable heterogeneous catalyst, which is applied to the reductive coupling of aromatic halides.
ChemInform Abstract: Efficient Copper‐Catalyzed Sonogashira Couplings of Aryl Halides with Terminal Alkynes in Water.
Authors: Yang Daoshan , Li Bing , Yang Haijun , Fu Hua , Hu Liming
Published: June 2011

Generally, good yields are obtained with aryl iodides under conditions A) and various functionalities are tolerated.
ChemInform Abstract: Copper‐Mediated Intermolecular Direct Biaryl Coupling.
Authors: Kitahara Masanori , Umeda Nobuyoshi , Hirano Koji , Satoh Tetsuya , Miura Masahiro
Published: June 2011

The reaction proceeds best in the presence of Cu(OAc)2 and PivOH and affords mixtures of mono‐ and bis‐coupling products in the case of para‐substituted 2‐phenylpyridines (I).
ChemInform Abstract: Direct Alkylation of Heteroaryls Using Potassium Alkyl‐ and Alkoxymethyltrifluoroborates.
Authors: Molander Gary A. , Colombel Virginie , Braz Valerie A.
Published: June 2011

Generally, the process provides the alkylated products with good yields and high functional group tolerance in both partners is observed.
ChemInform Abstract: Access to Enantiomerically Enriched cis‐2,3‐Disubstituted Azetidines via Diastereoselective Hydrozirconation.
Authors: Pradhan Tarun K. , Krishnan K. Syam , Vasse Jean‐Luc , Szymoniak Jan
Published: June 2011

The reaction proceeds in three steps including hydrozirconation/iodination/cyclization and affords the target azetidines mostly with excellent diastereoselectivity.
ChemInform Abstract: Pd/Cu‐Catalyzed Cascade Sonogashira Coupling/Cyclization Reactions to Highly Substituted 3‐Formyl Furans.
Authors: Yang Jingyu , Wang Chengyu , Xie Xin , Li Hongfeng , Li Ende , Li Yanzhong
Published: June 2011

A diversity of α‐bromoenaminones (I) and (IV) smoothly undergoes Pd/Cu‐catalyzed cascade Sonogashira cross coupling—cyclization reaction with aromatic and aliphatic terminal alkynes (II) to give polysubstituted 3‐formylfuran derivatives (III) and (V), resp., in good yields.
ChemInform Abstract: Base‐Mediated Regio‐ and Stereoselective Intermolecular Addition of Alkynes to N‐Heterocycles.
Authors: Verma Akhilesh Kumar , Joshi Megha , Singh Ved Prakash
Published: June 2011

The reaction of indole, pyrrole and imidazole derivatives with symmetrical internal or terminal alkynes proceeds with complete (Z)‐selectivity.
ChemInform Abstract: A New Synthesis of Pyrazoles Through a Lewis Acid Catalyzed Union of 3‐Ethoxycyclobutanones with Monosubstituted Hydrazines.
Authors: Shan Gang , Liu Pengfei , Rao Yu
Published: June 2011

The reaction is catalyzed by SnCl4 for tosyl hydrazine and by BF3·Et2O for all other monosubstituted hydrazine derivatives.
ChemInform Abstract: Environmental‐Benign Oxidation of 2‐Oxazolines to Oxazoles by Dioxygen as the Sole Oxidant.
Authors: Huang Yue , Ni Lijun , Gan Haifeng , He Yu , Xu Jinyi , Wu Xiaoming , Yao Hequan
Published: June 2011

A variety of 2‐arylsubstituted substrates is converted to oxazole derivatives using oxygen or air as a sole oxidant with comparable results.
ChemInform Abstract: One‐Pot Synthesis of 2‐Trifluoromethylchromones.
Authors: Henao Castaneda Isabel C. , Ulic Sonia E. , Della Vedova Carlos O. , Metzler‐Nolte Nils , Jios Jorge L.
Published: June 2011

A simple procedure is presented for the reaction of 2‐hydroxyacetophenones (I) with trifluoroacetic anhydride.
ChemInform Abstract: Organocatalytic Approach to Polysubstituted Piperidines and Tetrahydropyrans.
Authors: Wang You , Zhu Shaolin , Ma Dawei
Published: June 2011

A variety of polysubstituted piperidines and tetrahydropyrans is prepared generating up to 4 contiguous stereocenters in one step with excellent enantioselectivity.
ChemInform Abstract: Palladium‐Catalyzed Oxidative sp2 C—H Bond Acylation with Alcohols.
Authors: Xiao Fuhong , Shuai Qi , Zhao Feng , Basle Olivier , Deng Guojun , Li Chao‐Jun
Published: June 2011

The reaction proceeds under aerobic conditions and requires 3 equiv.
ChemInform Abstract: Mild Addition of Nucleophiles to Pyridine‐N‐Oxides.
Authors: Londregan Allyn T. , Jennings Sandra , Wei Liuqing
Published: June 2011

2‐Substituted pyridines are prepared under mild conditions.
ChemInform Abstract: Suzuki—Miyaura Cross‐Coupling and Ring‐Closing Metathesis: A Strategic Combination to the Synthesis of Indeno[1,2‐c]isoquinolin‐5,11‐diones
Authors: Lebrun Stephane , Couture Axel , Deniau Eric , Grandclaudon Pierre
Published: June 2011

as biologically interesting substances
ChemInform Abstract: A Fungal Nonribosomal Peptide Synthetase Module that Can Synthesize Thiopyrazines.
Authors: Qiao Kangjian , Zhou Hui , Xu Wei , Zhang Wenjun , Garg Neil , Tang Yi
Published: June 2011

A library of more than 60 different thiopyrazine compounds is prepared from amino acids and mercaptans.
ChemInform Abstract: Mesoporous Aluminosilicate‐Catalyzed Allylation of Carbonyl Compounds and Acetals.
Authors: Ito Suguru , Hayashi Akira , Komai Hirotomo , Yamaguchi Hitoshi , Kubota Yoshihiro , Asami Masatoshi
Published: June 2011

The reaction is applied to a wide range of aldehydes, acetals, ketones and ketals and allylsilanes.
ChemInform Abstract: Palladium‐Catalyzed Oxidative Allylic C—H Silylation.
Authors: Larsson Johanna M. , Zhao Tony S. N. , Szabo Kalman J.
Published: June 2011

The reaction applies hypervalent iodine reagents as oxidants, proceeds with complete or high (E)‐selectivity and tolerates a range of functional groups.
ChemInform Abstract: A Blue Digermene (t‐Bu2MeSi)2Ge=Ge(SiMet‐Bu2)2.
Authors: Lee Vladimir Ya. , McNeice Kiera , Ito Yuki , Sekiguchi Akira
Published: June 2011

The synthesis of the novel silylated digermene (II) is achieved via reduction of the dichlorine precursor (I) with potassium graphite.
ChemInform Abstract: Linear and Cyclic C‐Glycosides as Surfactants.
Authors: Foley Patrick M. , Phimphachanh Anthony , Beach Evan S. , Zimmerman Julie B. , Anastas Paul T.
Published: June 2011

7 Linear or cyclic C‐glycosides of type (III), (V), or (VI) are prepared from readily available nonulose (I) and aliphatic aldehydes.
ChemInform Abstract: Rapid Sonochemical Synthesis of Highly Luminescent Non‐Toxic AuNCs and Au@AgNCs and Cu(II) Sensing.
Authors: Liu Hongying , Zhang Xiang , Wu Ximei , Jiang Liping , Burda Clemens , Zhu Jun‐Jie
Published: June 2011

Highly fluorescent and water‐soluble gold nanoclusters with near‐IR emission (8% quantum yield) are prepared by sonication of an aqueous solution of HAuCl4 and bovine serum albumin at pH 12.
ChemInform Abstract: Novel C3‐Symmetric n‐Type Tris(aroyleneimidazole) and Its Analogues: Synthesis, Physical Properties and Self‐Assembly.
Authors: Hanifi David , Cao Dennis , Klivansky Liana M. , Liu Yi
Published: June 2011

The materials are shown to have desirable bandgaps and high thermal stability.
ChemInform Abstract: Instabilities in Doped Materials Driven by Pseudo Jahn—Teller Mechanisms
Authors: Garcia‐Fernandez P. , Trueba A. , Garcia‐Lastra J. M. , Barriuso M. T. , Moreno M. , Aramburu J. A.
Published: June 2011

Review: 253 refs.
ChemInform Abstract: Multiple‐Decker Sandwich Complexes of f‐Elements
Authors: Edelmann Frank T.
Published: June 2011

Review: 86 refs.
ChemInform Abstract: Direct Iron‐Catalyzed Cross‐Coupling Reactions
Authors: Czaplik Waldemar Maximilian , Mayer Matthias , Grupe Sabine , von Wangelin Axel Jacobi
Published: June 2011

Review: 56 refs.
ChemInform Abstract: Alkynes as “Masked” Ylides under Noble‐Metal Catalysis
Authors: Davies Paul W.
Published: June 2011

Review: 45 refs.
ChemInform Abstract: Rhodium‐ and Ruthenium‐Catalyzed Hydrogen Isotope Exchange
Authors: Lockley W. J. S. , Hesk D.
Published: June 2011

Review: 70 refs.
ChemInform Abstract: Reactions of Carboxylic, Phosphoric and Sulfonic Acids and Their Derivatives
Authors: Bedford C. T.
Published: June 2011

Review: 115 refs.
ChemInform Abstract: Reactions of Aldehydes and Ketones and Their Derivatives
Authors: Murray B. A.
Published: June 2011

Review: 355 refs.
ChemInform Abstract: Advances in the Krapcho Decarboxylation
Authors: Poon Po. S. , Banerjee Ajoy K. , Laya Manuel S.
Published: June 2011

Review: 26 refs.
ChemInform Abstract: The Literature of Heterocyclic Chemistry. Part 10. 2005—2007
Authors: Belen'kii L. I. , Gramenitskaya V. N. , Evdokimenkova Yu. B.
Published: June 2011

Review: ca. 1400 refs.
ChemInform Abstract: Fischer—Tropsch Synthesis over Molecular Sieve Supported Catalysts
Authors: Sun Bo , Qiao Minghua , Fan Kangnian , Ulrich Jeffrey , Tao Franklin Feng
Published: June 2011

Review: 128 refs.
ChemInform Abstract: Chemistry, Physico‐Chemistry and Applications Linked to Biological Activities of β‐Glucans
Authors: Barsanti Laura , Passarelli Vincenzo , Evangelista Valtere , Frassanito Anna Maria , Gualtieri Paolo
Published: June 2011

Review: 110 refs.
ChemInform Abstract: Sequential One‐Pot Combination of Multi‐Component and Multi‐Catalysis Cascade Reactions: An Emerging Technology in Organic Synthesis.
Authors: Ramachary Dhevalapally B. , Jain Sangeeta
Published: June 2011

Review: 91 refs.
ChemInform Abstract: New Development of Synthesis and Reactivity of Seleno‐ and Tellurophenes
Authors: Rhoden Cristiano R. B. , Zeni Gilson
Published: June 2011

Review: 110 refs.
ChemInform Abstract: β‐Protic Pyrazole and N‐Heterocyclic Carbene Complexes: Synthesis, Properties, and Metal—Ligand Cooperative Bifunctional Catalysis
Authors: Kuwata Shigeki , Ikariya Takao
Published: June 2011

Review: ca. 150 refs.
ChemInform Abstract: Construction of Diverse Ring Systems Based on Allene—Multiple Bond Cycloaddition
Authors: Inagaki Fuyuhiko Inagaki Fuyuhiko , Kitagaki Shinji , Mukai Chisato
Published: June 2011

Review: about 100 refs.
ChemInform Abstract: Nucleic Acid Based Molecular Devices
Authors: Krishnan Yamuna , Simmel Friedrich C.
Published: June 2011

Review: ca. 350 refs.
ChemInform Abstract: Understanding the Role of Water in Nonaqueous Pharmaceutical Systems
Authors: Anderson B. D. , Rane S. S. , Xiang T.‐X.
Published: June 2011

Review: 35 refs.
ChemInform Abstract: Chemical Synthesis of Bacterial Lipoteichoic Acids: An Insight on Its Biological Significance.
Authors: Schmidt Richard R. , Pedersen Christian M. , Qiao Yan , Zaehringer Ulrich
Published: June 2011

Review: ca. 80 refs.
ChemInform Abstract: Annual Lifelong Learning Program for Pharmaceutical Care Practice by Gifu Pharmaceutical University Pharmacy
Authors: Sugiyama Tadashi , Horiuchi Tadashi , Tsuchiya Teruo
Published: June 2011

Review: 16 refs.
Synthesis and Characterization of Polyureas from Aniline Trimer with TDI, MDI and HDI as pH Sensitive Materials
Authors: Liu Siwei , Zhang Yi , Xu Jiarui
Published: June 2011

A series of polyureas were synthesized through the reaction of aniline trimer with toluene‐diisocyanate, diphenylmethane‐4,4′‐diisocyanate, and hexamethylene‐1,6‐diisocyanate, respectively. The chemical structure of these polyureas was characterized and verified by FT‐IR, 1H NMR, elemental analysis, UV, XRD and CV. The conductivity of these polyureas ranged from 10−7 to 10−6 S/cm measured by four‐point‐probe instrument. Compared to the standalone aniline trimer, the stability (thermal stability and electrochemical stability), response range and sensitivity of these polyureas are enhanced. The sensitivity of these polyureas DMF solution to pH value is superior to that of the standalone aniline trimer. The color of the polyureas DMF solution is greatly depended on pH value and the color change process is reversible, whenever from base to acid or from acid to base. These enhancements may give these polyureas more opportunities in order to be used as sensor materials.
Efficient Synthesis of 2‐Arylamino‐2‐imidazolines and 2‐Ami‐ nobenzimidazoles with Aminoiminomethanesulfonic Acid Derivatives
Authors: Mohanazadeh Farajollah , Nami Navabe , Hosseini Samine Sadat
Published: June 2011

A highly efficient synthesis of 2‐arylamino‐2‐imidazolines and 2‐aminobenzimidazoles from aminoimino‐methanesulfonic acid derivatives is described. The method is simple and practical, generating imidazoline and benzimidazoline derivatives in excellent isolated yields.
Palladium‐catalyzed Coupling between Aryl Halides and Trimethylsilylacetylene Assisted by Dimethylaminotrimethyltin
Authors: Cai Liangzhen , Yang Dujuan , Sun Zhonghua , Tao Xiaochun , Cai Lisheng , Pike Victor W.
Published: June 2011

Palladium‐catalyzed coupling between aryl halides, especially less reactive ones or N‐heteroaryls, and trimethylsilylacetylene in the presence of dimethylaminotrimethyltin generated the coupled products in high yields. The reaction does not need CuI and base as auxiliary agents.
Preparation of Helical Mesoporous Ethenylene‐silica Nanofibers with Lamellar Mesopores on Their Surface
Authors: Zhang Ming , Li Yi , Bi Lifeng , Zhuang Wei , Wang Sibing , Chen Yuanli , Li Baozong , Yang Yonggang
Published: June 2011

The morphologies and pore architectures of mesoporous ethenylene‐silica were controlled using cetyltrimethylammonium bromide (CTAB) as template and (S)‐β‐citronellol as a co‐structure‐directing agent under basic conditions. When the (S)‐β‐citronellol/CTAB molar ratios are in the range of 0.75–2.0, helical nanofibers were obtained. With increasing the (S)‐β‐citronellol/CTAB molar ratio, the lengths of the nanofibers increases. Lamellar mesopores were identified on the surfaces of the nanofibers prepared in the (S)‐β‐citronellol/CTAB molar ratio range of 1.5–2.0. At the (S)‐β‐citronellol/CTAB molar ratio of 2.5:1, nanoparticles with nanoflakes on the surfaces were obtained. The field emission scanning electron microscopy images taken after different reaction times indicated that the helical pitches of the nanofibers decreased with increasing the reaction time. Helical 1,4‐phenylene‐silica and methylene‐silica nanofibers were also prepared. The results indicated that the morphologies and pore architectures of the obtained organic‐inorganic hybrid silicas are also sensitive to the hybrid silica precursors. Helical ethenylene‐silica nanofibers with lamellar mesopores on their surfaces can be also prepared using the mixtures of CTAB and racemic citronellol within a narrower citronellol/CTAB molar ratio range.
Silica Chloride Nano Particle Catalyzed Ring Opening of Epoxides by Aromatic Amines
Authors: Karimian Ramin , Piri Farideh , Karimi Babak , Abolghasem Moghimi
Published: June 2011

Silica chloride nano particle (nano SiO2‐Cl), has been found to be heterogeneous catalyst for facile, simple and mild ring opening of epoxides with aromatic amines to afford β‐amino alcohols in dry CH2Cl2 at room temperature.
Synthesis of Mono‐ and Di‐fluorinated Benzimidazoles
Authors: Liang Wu , Liu Gang
Published: June 2011

Three efficient methods to synthesize mono‐ and di‐fluorinated benzimidazoles are reported. These methods provide 5‐amino‐6‐fluoro‐benzimidazoles (5), 5,7‐difluoro‐benzimidazoles (10), and 6‐fluoro‐benzimidazoles (13) starting from commercially available 1,5‐difluoro‐2,4‐dinitrobenzene (DFDNB), 2,3,4,5‐tetrafluoro‐6‐nitrobenzoic acid (TFNBA), and 2,4‐difluoro‐1‐nitrobenzene (DFNB), respectively.
A Solution‐Phase Parallel Synthesis of 5‐Substituted 3,6‐Dihydro‐7H‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐ones
Authors: Sun Shaofa , Chen Li , Yang Xuhong
Published: June 2011

5‐Substituted 7H‐1,2,3‐triazolo[4,5‐d]pyrimidin‐7‐ones (4) were rapidly prepared by a solution‐phase parallel synthetic method, which includes aza‐Wittig reaction of iminophosphorane (1) with phenyl isocynate to give carbodiimide (2) and subsequent reaction of 2 with various amine and alcohols in the presence of catalytic amount of sodium alkoxide in a parallel fashion.
Appropriate Therapy But Not Inappropriate Shocks Predict Survival in Implantable Cardioverter Defibrillator Patients
Authors: Dichtl Wolfgang , Wolber Thomas , Paoli Ursula , Brüllmann Simon , Stühlinger Markus , Berger Thomas , Spuller Karin , Strasak Alexander , Pachinger Otmar , Haegeli Laurent M. , Duru Firat , Hintringer Florian
Published: June 2011

Background:

Inappropriate implantable cardioverter defibrillator (ICD) shocks have been linked to a worse clinical outcome due to direct myocardial injury.

Hypothesis:

The occurrence of ventricular tachyarrhythmia indicating progression of the underlying heart disease, but not the ICD shock itself, has prognostic impact in clinical routine.

Methods:

In a retrospective study, 1117 recipients of an ICD were analyzed with respect to appropriate and inappropriate therapies and survival.

Results:

During a mean follow‐up of 2.92 years, appropriate therapy occurred in 27.7% and 54.0% of patients who had received an ICD for primary and secondary prevention of sudden cardiac death (SCD), respectively (P<0.0001). Inappropriate shock therapy occurred in 15.0% and 25.4% of patients who had received an ICD for primary and secondary prevention of SCD, respectively (P = 0.122). Appropriate ICD therapy had a strong impact on overall survival (P<0.0001), and this association was found both in primary (P<0.0001) and secondary (P = 0.002) prevention of SCD. Inappropriate ICD shocks had no impact on total mortality, neither in primary nor secondary prevention of SCD.

Conclusions:

Inappropriate shocks do not affect survival, in strong contrast to appropriate ICD therapy. Our study does not support the hypothesis that shock therapy in itself worsens clinical outcome. However, it confirms that appropriate ICD therapy is a warning sign and should prompt physicians to consider additional treatment strategies. © 2011 Wiley Periodicals, Inc.

The authors have no funding, financial relationships, or conflicts of interest to disclose.
Polyphosphates and Pyrophosphates of Pentopyranoses and Pentofuranoses as Allosteric Effectors of Human Hemoglobin: Synthesis, Molecular Recognition, and Oxygen Release
Authors: Fylaktakidou Konstantina C. , Duarte Carolina D. , Jogireddy Rajamalleswaramma , Koumbis Alexandros E. , Nicolau Claude , Lehn Jean‐Marie
Published: June 2011

Perphosphorylated pentopyranoses and pentofuranoses were synthesized from parent carbohydrates as potential allosteric effectors of hemoglobin (Hb). The construction of seven‐ and eight‐membered cyclic pyrophosphates was also carried out successfully on most of the pentoses. All final compounds were tested for their efficiency on oxygen release from human Hb. Most proved to be efficient allosteric effectors, some of them with an affinity toward Hb and an effect on oxygen release from Hb approaching that of myo‐inositol hexakisphosphate, which is one of the most active allosteric effectors of Hb. The efficacy was higher for free phosphates than for pyrophosphates.
Exuberant growth and synapse formation of olfactory sensory neuron axonal arborizations
Authors: Marcucci Florencia , Maier‐Balough Elizabeth , Zou Dong‐Jing , Firestein Stuart
Published: June 2011

Neural connections in the adult nervous system are established with a high degree of precision. Several examples throughout the nervous system indicate that this precision is achieved by first establishing an initial exuberant immature pattern of connectivity that is then sculpted into the adult pattern via pruning. This often emerges as an activity‐dependent process. In the olfactory system, sensory axons from neurons expressing the same odorant receptor project with high precision to specific glomerular structures in the olfactory bulb. This process undergoes maturation‐dependent refinements that are not fully understood. Due to technical impediments that have made it difficult to focus on single axons, it is unknown whether olfactory sensory projections are established in an exuberant fashion. Here we developed a novel technique of electroporation that allowed us to simultaneously label single olfactory sensory neuron (OSN) axonal arbors and their presynaptic specializations. Using this method we were able to incorporate plasmids into OSNs at an immature stage, thereby allowing a time‐course study of axonal arbor development and synapse formation in single olfactory sensory axons. We observed that the number of branch points, the total branch length, and the number and density of presynaptic specializations peaked at postnatal day 8 and decreased afterwards. Our data demonstrate that olfactory sensory axons develop in an exuberant way, both in terms of branch growth and synaptic composition. We hypothesize that exuberant branches and synapses are eliminated to achieve the mature pattern in a process likely to be regulated by neural activity. J. Comp. Neurol.519:3713‐3726, 2011. © 2011 Wiley‐Liss, Inc.
A‐kinase anchoring protein 150 expression in a specific subset of TRPV1‐ and CaV1.2‐positive nociceptive rat dorsal root ganglion neurons
Authors: Brandao Katherine E. , Dell'Acqua Mark L. , Levinson S. Rock
Published: June 2011

Modulation of phosphorylation states of ion channels is a critical step in the development of hyperalgesia during inflammation. Modulatory enhancement of channel activity may increase neuronal excitability and affect downstream targets such as gene transcription. The specificity required for such regulation of ion channels quickly occurs via targeting of protein kinases and phosphatases by the scaffolding A‐kinase anchoring protein 79/150 (AKAP79/150). AKAP79/150 has been implicated in inflammatory pain by targeting protein kinase A (PKA) and protein kinase C (PKC) to the transient receptor potential vanilloid 1 (TRPV1) channel in peripheral sensory neurons, thus lowering threshold for activation of the channel by multiple inflammatory reagents. However, the expression pattern of AKAP150 in peripheral sensory neurons is unknown. Here we identify the peripheral neuron subtypes that express AKAP150, the subcellular distribution of AKAP150, and the potential target ion channels in rat dorsal root ganglion (DRG) slices. We found that AKAP150 is expressed predominantly in a subset of small DRG sensory neurons, where it is localized at the plasma membrane of the soma, axon initial segment, and small fibers. Most of these neurons are peripherin positive and produce C fibers, although a small portion produce Aδ fibers. Furthermore, we demonstrate that AKAP79/150 colocalizes with TRPV1 and CaV1.2 in the soma and axon initial segment. Thus AKAP150 is expressed in small, nociceptive DRG neurons, where it is targeted to membrane regions and where it may play a role in the modulation of ion channel phosphorylation states required for hyperalgesia. J. Comp. Neurol., 2012. © 2011 Wiley Periodicals, Inc.
Postnatal changes in the distribution and density of neuronal nuclei and doublecortin antigens in domestic chicks (Gallus domesticus)
Authors: Mezey Szilvia , Krivokuca Dragan , Bálint Eszter , Adorján András , Zachar Gergely , Csillag András
Published: June 2011

To understand better the rate of neurogenesis and the distribution of new neurons in posthatch domestic chicks, we describe and compare the expression of the neuronal nuclei protein (NeuN, a.k.a. Fox‐3) and doublecortin antigens in the whole brain of chicks 2 days, 8 days, and 14 weeks posthatch. In the forebrain ventricular and paraventricular zones, the density of bromodeoxyuridine‐, NeuN‐, and doublecortin‐labeled cells was compared between chicks 24 hours and 7 days after an injection of bromodeoxyuridine (2 and 8 days posthatch, respectively). The distribution of NeuN‐labeled neurons was similar to Nissl‐stained tissue, with the exception of some areas where neurons did not express NeuN: cerebellar Purkinje cells and olfactory bulb mitral cells. The ventral tegmental area of 2‐day‐old chicks was also faintly labeled. The distribution of doublecortin was similar at all timepoints, with doublecortin‐labeled profiles located throughout all forebrain areas as well as in the cerebellar granule cell layer. However, doublecortin labeling was not detectable in any midbrain or brainstem areas. Our data indicate that a significant number of new neurons is still formed in the telencephalon of posthatch domestic chicks, whereas subtelencephalic areas (except for the cerebellum) finish their neuronal expansion before hatching. Most newly formed cells in chicks leave the paraventricular zone after hatching, but a pool of neurons stays in the vicinity of the ventricular zone and matures in situ within 7 days. Proliferating cells often migrate laterally along forebrain laminae into still‐developing brain areas. J. Comp. Neurol., 2012. © 2011 Wiley Periodicals, Inc.