bluuebunny/crossref_metadata_2025 huggingface dataset:
Radiodermatitis as a Consequence of Radiation Recall Induced by Acyclovir: Case Report.
Authors: Zorzan Marcos Tumitan , Pereira Renata de Mello , Lima Lucas Farina , Mattos Tatiana Veri de Arruda , Sá Rafael
Published: September 2020

Background: Radiation Recall Dermatitis is defined as an inflammatory reaction in a site of skin previously submitted to radiotherapy, and succeeding the administration of a drug or promoter agent. Manifestations range from mild to severe, resulting in tissue necrosis, treated with removal of the probable causative agent, daily dressings and surgical debridement of the necrotic area.Case presentation: The patient whose case is reported presented previous diagnosis of intraductal carcinoma in situ, performed lumpectomy and adjuvant radiotherapy and endocrinotherapy. After 1 year of treatment, develops sores suggestive of Herpes Zoster and starts treatment with Acyclovir, concomitantly with the onset of pain, fever, and in the previously irradiated area, breast hardening, skin infiltration and serosanguinolent discharge. Performed incisional biopsy to rule out radioinduced sarcoma, being treated with surgical debridement.Conclusions: Unlike the cases report of acyclovir drug’s eruption, the patient presented radiodermatitis restricted to the skin’s tissue in the previously irradiated area, suggestive of the radiation recall. This case report describes the acyclovir as a possible indutor of RRD, a rare condition that requires a better understanding of the disease installation mechanism and the adverse drugs effects after radiotherapy.
Microwave Photonic Ising Machine
Authors: Cen Qizhuang , Hao Tengfei , Ding Hao , Guan Shanhong , Qin Zhiqiang , Xu Kun , Dai Yitang , Li Ming
Published: September 2020

Ising machines based on analog systems have the potential of acceleration in solving ubiquitous combinatorial optimization problems. Although some artificial spins to support large-scale Ising machine is reported, e.g. superconducting qubits in quantum annealers and short optical pulses in coherent Ising machines, the spin coherence is fragile due to the ultra-low equivalent temperature or optical phase sensitivity. In this paper, we propose to use short microwave pulses generated from an optoelectronic parametric oscillator as the spins to implement the Ising machine with large scale and also high coherence under room temperature. The proposed machine supports 10,000 spins, and the high coherence leads to accurate computation. Moreover, the Ising machine is highly compatible with high-speed electronic devices for programmability, paving a low-cost, accurate, and easy-to-implement way toward to solve real-world optimization problems.
Screening and Identification of Novel Biomarkers Associated with Cutaneous Squamous Cell Carcinoma
Authors: Su Wenxing , Huang Biao , Han Wei , An Lu , Guan Yi , JI Jiang , Yu Daojiang
Published: September 2020

Background: Cutaneous squamous cell carcinoma (cSCC) is the leading cause of death in patients with non-melanoma skin cancers (NMSC). However, unclear pathogenesis of cSCC limits the application of molecular targeted therapy. Results: To identify the hub genes in the pathogenesis and progression of cSCC, we downloaded the microarray data sets GSE2503, GSE45164 and GSE66359 from the Gene Expression Omnibus (GEO) database, and identified differentially expressed genes (DEGs) between tumor and non-tumor tissues. Functional enrichment analysis was performed using DAVID. The STRING online website was used to construct a protein-protein interaction network (PPI), and then Cytoscape performed module analysis and degree calculation. 146 DEGs were identified with significant differences, including 113 up-regulated genes and 33 down-regulated genes. The enriched functions and pathways of the DEGs include microtubule-based movement, ATP binding, cell cycle, p53 signaling pathway, oocyte meiosis and PLK1 signaling events. Nine hub genes were identified, namely CDK1, AURKA, RRM2, CENPE, CCNB1, KIAA0101, ZWINT, TOP2A, ASPM. The differential expression of these genes has been verified in other data sets. In addition, the ROC curve also confirmed their ability to predict disease. Conclusion: By integrated bioinformatic analysis, the DEGs and hub genes identified in this study elucidated the molecular mechanism of the pathogenesis and progression of cSCC, and are expected to become future biomarkers or therapeutic targets.
Application of Network Pharmacology to Elucidate The Potential Mechanism of Finger Citron Against Obesity
Authors: Wu Zhen , Yang Yujiao , Wei Yao , Hu Xu-guang
Published: September 2020

Background: Finger citron (FS) is one of many traditional Chinese herbs that have been used to treat obesity. However, the active components and potential targets of FS in improving obesity remain unclear. Methods：The aim of this study was to elucidate the pharmacological effects and mechanisms of FS on obesity using network pharmacology analysis. We used network pharmacology to determine the active components, potential targets and mechanisms in the treatment of obesity.Results：We identified 25 active ingredients of FS such as diosmetin, hesperidin and sitosterol-alpha1 with important biological effect. A total of 258 key targets were screened, containing TNF，NOS2, MAPK8 which were found to be enriched in 27 signaling pathways, such as apoptosis, TNF, PPAR and AKT1, and Insulin resistance signaling pathways. Moreover, molecular docking analysis showed that the main ingredients were tightly bound to the core targets, further confirming the effects of weight loss. Conclusion: Based on network pharmacology and molecular docking analysis, our study provides insights into the potential mechanism of FS in ameliorating obesity after screening for associated key target genes and signaling pathways. These findings further provide a theoretical basis for further pharmacological research into the potential mechanism of FS in treating obesity.
Psychological Impact and Associated Factors During the Containment Stage of Covid-19 Epidemic Among College Students in China
Authors: Si Mingyu , Su Xiao-You , Jiang Yu , Wang Wen-Jun , Gu Xiao-Fen , Ma Li , Li Jing , Zhang Shao-Kai , Ren Ze-Fang , Liu Yuan-Li , Qiao You-Lin
Published: September 2020

Background College students are a uniquely vulnerable group and may experience high stress levels due to COVID-19. This study aims to identify the the psychological state and related factors on Chinese college students during the initial phases of the COVID-19 pandemic. Methods From February 23 to March 5, 2020, a cross-sectional online survey was conducted among 3606 college students from seven provinces in China using standard questionnaires measuring adverse psychological outcomes and related factors including Impact of Event Scale-6 (IES-6), Depression, Anxiety and Stress Scale (DASS), Perceived Social Support Scale (PSSS) and Simplified Coping Style Questionnaire (SCSQ). Exploratory factor analysis (EFA) were used to determine underlying constructs of the perceived threat items. Multivariate regression was used to explore the determinants of adverse psychological impact. Results Posttraumatic stress (PTS) were prevalent in this sample of college students, and 34.22% met the cut-off for posttraumatic stress disorder (PTSD). The proportion of having mild to extremely severe symptoms of depression, anxiety and stress were 15.70%, 13.31% and 7.10%, respectively. The impact of closed-off management on life, perceived threat and passive coping strategies were positively correlated to PTS and DASS scores, while knowledge score, perceived social support and active coping strategies were negatively correlated to DASS scores. Conclusions In summary, adverse psychological symptoms were prevalent among college students in China during the COVID-19 epidemic. Identifying vulnerable populations and formulating correspondingly psychological interventions would be beneficial to improve the mental health during the COVID-19 epidemic.
Identification of Molecular Biomarkers in Taiwanese Patients with Wilms Tumor Using a Methylation-Specific Multiplex Ligation-Dependent Probe Amplification (MS-MLPA)-Based Approach
Authors: Lu Meng-Yao , Wang Wen-Chung , Hou Tai-Cheng , Kuo Chen-Yun , Lai Yen-Chein
Published: September 2020

Background: Wilms tumor is a solid tumor that frequently occurs in children. Genetic or epigenetic aberrations in WT1 and WT2 loci are implicated in its etiology. Moreover, tumor suppressor genes are frequently silenced by methylation in this tumor. Methods: In the present study, we analyzed the methylation statuses of promoter regions of 24 different tumor suppressor genes using a methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA)-based approach in six Wilms tumors. Results: All six Wilms tumors showed methylation of RASSF1 specific to tumors, not in normal tissues. Moreover, methylated HIC1 was identified in stromal type Wilms tumors and methylated BRCA1 was identified in epithelial type Wilms tumors. Unmethylated CASP8, RARB, MLH1_167, APC, and CDKN2A were found only in blastemal predominant type Wilms tumors. Conclusions: Our results indicated that methylation of RASSF1 is the essential event in the tumorigenesis of Wilms tumor, which may inform its clinical and therapeutic management. In addition, mixed type Wilms tumors may be classified according to epithelial, stromal, and blastemal components via MS-MLPA-based approach.
Cancer Stem Cell Transcriptome Landscape Reveals Biomarkers Driving Breast Cancer Heterogeneity
Authors: Zhang Zhifa , Chen Xiao , Zhang Jianying , Dai Xiaofeng
Published: September 2020

BackgroundBreast cancers are heterogeneous diseases with distinct clinical outcomes and cancer stem cell percentages. Exploring breast cancer stem cell landscape could help understand the heterogeneity of such cancers with profound clinical relevance.MethodsWe conducted transcriptional profiling of cancer stem cells and non-cancer stem cells isolated from 3 triple negative breast cancer cell lines, analyzed the cancer stem cell transcriptome landscape that drives breast cancer heterogeneity through differential expressed gene analysis, gene ontology and pathway enrichment as well as network construction, and performed experimental validations on the network hub gene.ResultsWe identified a cancer stem cell feature panel consisting of 122 and 381 over-represented and under-expressed genes capable of differentiating breast cancer subtypes. We also underpin the prominent roles of the PI3K-AKT pathway in empowering cancer cells with uncontrolled proliferative and migrative abilities that ultimately foster cancer stemness, and reveal the potential promotive roles of ATP6V1B1 on breast tumor stemness through functional in vitro studies. ConclusionsOur study contributes in identifying a cancer stem cell feature panel for breast tumors that drives breast cancer heterogeneity at the transcriptional level, which provides a reservoir for diagnostic marker and/or therapeutic target identification once experimentally validated as demonstrated by ATP6V1B1.
Epidemiological and Clinical Characteristics and Risk Factors for Mortality of Inpatients with COVID-19 in Golestan Province, Iran: A Retrospective Cohort Study
Authors: Honarvar Mohammad Reza , Roshandel Gholamreza , Shirzad-Aski Hesamaddin , Tabarraei Alijan , Tahamtan Alireza , Ghelichi-Ghojogh Mousa , Fazel Abdolreza , Arefnia Serajeddin , Jafari Nahid , Mansoury Mohsen , Rajabi Abdolhalim
Published: September 2020

Background: Coronavirus disease 2019 (COVID-19) is an emerging infectious disease that was first reported in Wuhan, China, and has subsequently spread worldwide. We aimed to further clarify the epidemiological and clinical characteristics of 2019-nCoV pneumonia and risk factors associated for mortality. Methods: In this retrospective cohort study, we included inpatient with acute respiratory distress syndrome at Golestan University of Medical Sciences Hospitals (Golestan province, Iran) who had been discharged or had died in 2020. Epidemiological, clinical, and laboratory data, including samples for viral RNA detection, were extracted from electronic medical records and compared between recovered and died cases. We used multiple logistic regression methods to explore the risk factors associated with in-hospital death.Results: In overall 2,835 acute respiratory distress syndrome patients were included in this study, of these patients, 874 (30.83.9%) were positive for 2019­nCoV, and 1,046 (36.90%) were negative and 915 (32.28%) were not available for PCR result. Five hundred and sixty-three patients (19.86%) died, 1,687 patients (59.51%) were recovered, and 585 (20.63%) under treatment. Of the total deaths, only 288 (10.15%) were attributed to COVID-19. The most common symptoms at onset of illness were respiratory distress (1,795 [63.32%]), fever (1,601 [56.47%]), dry cough (1,595 [56.26%]), Sore throat (445 [15.70%]), and myalgia (342 [12.06%]).One thousand and twelve (35.7%) had 1 or more coexisting medical conditions. In multiple logistic regression analysis, risk factors associated with the death included older age (OR (Odds Ratio), 1.03; 95% CI; 1.02-1.04), blood oxygen level (SpO2<93%) (OR, 2.44; 95% CI; 1.79-3.31), comorbidities (OR, 2.15; 95% CI; 1.62-2.84), respiratory distress (OR, 1.74; 95% CI; 1.28-2.37), and headache (OR, 0.44 95% CI; 0.21-0.92). Conclusions: The 2019-nCoV infection caused collections of severe respiratory illness and was associated high ratio of hospitalization in ICU and high mortality. Older age and comorbidities were associated with more risk of death among patients with 2019­nCoV.
WITHDRAWN: Detection of Political Intent Through Analysis of Tweets and Homophily Elements
Authors: SHETTY NISHA P , Muniyal Balachandra , Teja Daita Ravi , Maben Leander
Published: September 2020

Twitter is one of the most popular social networking platforms of today’s generation and is a fundamental tool in harvesting the data of many users worldwide. Many discussions ranging from current affairs, news sharing, filing complaints to advertising and discussing some common interests etc. happen on Twitter. It is widely used by many famous politicians as a prominent communication medium to address large masses ,owing to its mass usage and popularity . Thus, it is safe to assume that people communicate their political ideologies on Twitter. Many works have been done so far to deduce the stance of user towards a particular party by performing sentiment analysis on their tweets using popular classifiers. To find connected and similar users, earlier works generated a social network graph, based on the assumption that friends and followers share similar interests, which might not be true in all cases. In contrast, the proposed work employs the concept of ensemble classifier (a single classifier generated from several base learning classifiers) to analyze the tweets and makes use of multiple interaction elements like followers/ following, mentions, re-tweets ,hash tags etc. to infer which political party a user identifies with. These interaction elements project out the homophily (users who share same beliefs and choices) amongst the users. The proposed study can be encompassed to any domain and can be used by advertising agencies, marketing companies, e-commerce, heath care etc. to identify their target audience.
A Randomized, Double Blind, Vehicle Controlled, Parallel, Phase Ii Study to Evaluate Efficacy and Safety of Bac in Patients With Alzheimer’s Disease or Vascular Dementia
Authors: Thein Stephen , Konis George , Lacey Dennis Michael , Hudefi Fayz , Vandersluis Joel , Papka Michelle , Sharma Sanjiv , Anderson Corey G. , Jagadeesan Singaravelu , Fink Evgeny , Pai Ming-Chyi
Published: September 2020

Background: Dementia causes a long-term and gradual cognitive decline and there is no treatment to slow or stop the progression of dementia. Methods: Middle cerebral artery occlusion in rats was employed to investigate the effects of BAC in neural inflammation. A phase II study was conducted in Alzheimer’s disease or vascular dementia patients. BAC or matched vehicle was applied topically on the subject’s external nasal skin, scalp, and neck, twice daily, 30 grams per day for 12 weeks. Cognitive evaluation questionnaires including ADAS-Cog, ADCS-ADL, MMSE, NPI, CIBIS, and CIBIC-plus scores were performed to evaluate the efficacy. A responder analysis was conducted with stratification of different sub-groups of receiving/not receiving dementia medication or donepezil hydrochloride and type of dementia.Results: The responder analysis showed that the naïve and not using donepezil hydrochloride sub-groups in the BAC-treated group had a higher responder rate compared to using donepezil hydrochloride and any dementia medication sub-groups. The BAC group showed a higher percentage of responders than the vehicle group in the mixed dementia population.Conclusion: BAC was safe for human use. BAC improved the responder rate in naïve dementia patients regardless of dementia type and in patients not receiving donepezil hydrochloride. The bigger sample size is required to confirm the efficacy of BAC.Trial registration: NCT02886494 (First posted: September 1, 2016)
Nanosized octahedral LiNi0.5Mn1.5O4 with predominant (111) facet as high performance cathode for Lithium-ion batteries
Authors: Rong Haibo , Deng Binglu , Chen Dongchu , Chen Min
Published: September 2020

Nanosized octahedral LiNi0.5Mn1.5O4 with predominant (111) facet has been successfully fabricated using Mn3O4 nanoparticles precursors via a two-step synthesis, which involves a hydrothermal treatment and the subsequent calcination. The physical properties of the Mn3O4 precursor and the resultant LiNi0.5Mn1.5O4 were characterized by XRD (X-ray diffraction), TEM (transmission electron microscopy) and SEM (scanning electron microscopy). The charge-discharge tests show that the resultant LiNi0.5Mn1.5O4 exhibits excellent cyclability and rate capability, which delivers a discharge capacity of about 117 mAh g− 1 after 300 cycles, and maintains 94% of its initial discharge capacity (124.7 mAh g− 1) at 1C, even at a rate of 40C, a specific capacity of 99.2 mAh g− 1 could be still obtained for the O-LNMO. The superior electrochemical performance of the LNMO is mainly attributed to the synergistic effect of the nanosized octahedral structure and exposed (111) facets of the prepared LiNi0.5Mn1.5O4. We found that the nanosized octahedral structure can not only accommodate the lattice stress caused by John-Teller distortion but also provide short paths for Li+ ion transportation in the material. Additionally, the obtained predominant (111) facet is helpful to the formation of protective SEI film on the spinel LiNi0.5Mn1.5O4 electrode.
Preparation and properties of B4C-TiB2 ceramics prepared by spark plasma sintering
Authors: Fan Jingzhe , Shen Weixia , Zhang zhuangfei , Fang Chao , Zhang Yuewen , Chen Liangchao , Wang Qianqian , Wan Biao , Jia Xiaopeng
Published: September 2020

By doping titanium hydride (TiH2) into boron carbide (B4C), a series of B4C + x wt% TiH2 (x = 0, 5, 10, 15 and 20) composite ceramics were obtained through spark plasma sintering (SPS). The effects of sintering temperature and the amount of TiH2 additive on the microstructure, mechanical and electrical properties of the sintered B4C-TiB2 composite ceramics were investigated. Powder mixtures of B4C with 0−20 wt% TiH2 were heated from 1400 to 1800 °C for 20 minutes under 50 MPa. The results indicated that higher sintering temperatures contributed to greater ceramic density. With increasing TiH2 content, titanium diboride (TiB2) formed between the TiH2 and B4C matrix. This effectively improved Young’s modulus and fracture toughness of the composite ceramics, significantly improving their electrical properties: the electrical conductivity reached 114.9 S·cm−1 at 1800 °C when x = 20. Optimum mechanical properties were obtained for the B4C ceramics sintered with 20 wt% TiH2, which had a relative density of 99.9 ± 0.1%, Vickers hardness of 31.8 GPa and fracture toughness of 8.5 MPa·m1/2. The results indicated that the doping of fine Ti particles into the B4C matrix increased the conductivity and the fracture toughness of B4C.
The effect of heteroatoms on the formation of magnetic ceramic nanocomposites in pyrolysis of organometallic precursors: similar molecular structure, but totally different morphology, composition and properties
Authors: Ruan Zhijun , Ran Jingwen , Liu Shanshan , Chen Yanmei , Wang Xichao , Shi Jie , Zhu Lihong , Zhao Shengfang , Lin Junqi
Published: September 2020

Four organometallic compounds were synthesized for solid-state pyrolysis (SSP) to research the structure-property relationship between the precursors and the as-generated magnetic ceramic nanocomposites (MCNs). In which, the only saturated carbon atom in MC was replaced by N or O or S atom, to produce MN, MO and MS, respectively. It was found that, the crystal phase of the cobalt catalyst could be regulated by introducing different heteroatoms during the pyrolysis: fcc-Co for MC/MN, while fcc/hcp-Co hybrid for MO/MS. Metal cobalt with different crystal phases has their special catalytic and magnetic properties. Thus, MCNs with totally different morphology, composition and properties could be prepared by just changing one heteroatom in the precursors upon SSP. Uniform nanotubes were generated from pyrolysis of MC/MN, while nanospheres were generated from MO/MS. The obtained MCNs all show excellent magnetic properties with Ms ranged from 47.6 to 54.2 emu g-1. Analyzing carefully, due to the magnetic difference between fcc-Co and hcp-Co, the Ms of the MCNs obtained from MO/MS were slightly lower than those of MC/MN, but, their Mr and Hc were 2 to 5 times higher than the latter.
Regulatory mechanism of lncRNA HCP5 in nasopharyngeal carcinoma cell proliferation and apoptosis via the miR-140-5p/NPR3 axis
Authors: Huang Bo , Li Yiliang , Deng Zhuoxia , Lan Guiping , Si Yongfeng , Zhou Qiao
Published: September 2020

Objectives

Nasopharyngeal carcinoma (NPC) is malignant tumor frequently occurring in east and southeast Asia. This study investigated the underlying mechanism of lncRNA HCP5 in NPC cell proliferation and apoptosis.
Methods

LncRNA HCP5 expression in NPC cells and tissues was detected. SUNE-1 cells were transfected with HCP5 silencing and CNE-1 cells were transfected with overexpressing HCP5, and then cell proliferation and apoptosis were measured. Subcellular localization of HCP5 was analyzed. The binding relationship between lncRNA HCP5 and miR-140-5p, and miR-140-5p and NPR3 were predicted and verified. Expressions of miR-140-5p and NPR3 in NPC cells were detected. SUNE-1 cells and CNE-1 cells were transfected with miR-140-5p mimic, and si-HCP5-transfected SUNE-1 cells were treated with miR-140-5p inhibitor. Then the proliferation and apoptosis of NPC cells were detected.
Results

LncRNA HCP5 was elevated in NPC tissues and cells. HCP5 silencing suppressed NPC cell proliferation and enhanced apoptosis. HCP5 was mainly located in the cytoplasm of NPC cells. HCP5 promoted NPR3 expression by competitively binding to miR-140-5p. Overexpression of miR-140-5p weakened proliferation and facilitated apoptosis of NPC cells. miR-140-5p inhibitor partially restored the effects of HCP5 silencing on NPC cells.
Conclusion

LncRNA HCP5 upregulated NPR3 expression via sponging miR-140-5p, thereby suppressing NPC cell proliferation and promoting apoptosis. This study may offer new insights into NPC treatment.
Clinical value and characteristic of absolute counts of lymphocyte subsets in patients with pulmonary tuberculosis: a large-scale Hospital-Based Study
Authors: Liang Jianqin , Bai Xuejuan , An Huiru , Wang Tao , Wang Zhongyuan , Liu Yinping , Xue Yong , Wu Xueqiong
Published: September 2020

Background

This research aimed to investigate the clinical value and characteristics of peripheral blood lymphocyte subsets in tuberculosis (TB) patients by flow cytometry.
Methods

The Absolute counts of T, CD4+ T, CD8+ T, NK, NKT and B lymphocytes were detected in 217 cases of pulmonary TB (PTB), 163 cases of PTB & extra-PTB and 65 cases of extra-PTB patients. We analyzed the change characteristic of subset counts with the clinical parameters in PTB and compared the subsets differences among PTB, PTB with extra-PTB, and extra-PTB patients.
Results

The absolute counts of six subsets in 75.3% of PTB patients were lower than the normal reference range, and 44% patients showed lower CD4+ lymphocytes. (1) The absolute counts of T, CD4+ T, CD8+ T and B lymphocytes was significantly lower in patients older than 60 years old. (2) The NKT cell counts was significantly lower in female patients than the males; (3) 40.8% of patients with positive etiological results and 49.2% of extra-PTB patients showed lower CD8+ T and NK cell counts below the reference range respectively. (4) The T and CD4+ T lymphocyte counts in PTB with positive IGRA were significantly higher than those with negative IGRA; (5) The T and CD8+ T cell counts in PTB with positive IgG antibody were decreased; (6) The T, CD4+ T, CD8+ T and B cell counts reduced with the increasing lesion lobe numbers, accelerated ESR, complications with anemia and low serum albumin, and NK cells also decreased in patients with anemia and low serum albumin; and the T, CD8+, and B cells significantly decreased in PTB patients with diabetes, while NKT increased.
Conclusions

The immune function in most TB patients is impaired and the absolute counts of lymphocyte subsets could be used as the evidence for immune intervention and monitoring the curative effect.
SPOCK1 and POSTN are Valuable Prognostic Biomarkers and Correlate With Tumor Immune Infiltrates in Colorectal Cancer
Authors: Li Mengting , Li Wenjie , Wang Haizhou , Peng Yanan , Hu Qian , Wei Wanhui , Gan Caiqin , Wang Fan , Liu Lan , Zhao Qiu
Published: September 2020

BackgroundImmune cells and stromal cells in the tumor microenvironment (TME) play a vital role in the initiation and progression of colorectal cancer (CRC). The study aimed to screen valuable prognostic biomarkers in CRC on the basis of stromal and immune scores.MethodsWe used the ESTIMATE algorithm to calculate the immune and stromal scores of CRC samples in TCGA. Then the CRC samples were divided into high and low score groups based on the median value of the immune and stromal scores. Differentially expressed genes (DEGs) associated with immune score and stromal score were screened. WGCNA and univariate COX regression analysis were performed to further identify key prognostic genes. The prognostic value of key genes was validated based on The Gene Expression Profiling Interactive Analysis (GEPIA) and GSE17536 dataset. TIMER and CIBERSORT algorithms were applied to analyze the correlations among key genes and tumor-infiltrating immune cells. Results1314 upregulated and 4 downregulated genes associated with immune score and stromal score were identified, which were significantly enriched in immune-related biological processes and pathways. Among these DEGs, SPOCK1 and POSTN were identified as key prognostic genes. High expression of SPCOK1 and POSTN was associated with advanced clinical stage, T stage, N stage, and poor prognosis of CRC. The results from CIBERSORT and TIMER revealed that SPOCK1 and POSTN were associated with tumor-infiltrating immune cells, especially macrophages and neutrophils. Besides, SPOCK1 and POSTN expression were positively correlated with the expression of immune checkpoints.ConclusionCollectively, our results indicate that SPOCK1 and POSTN may be novel prognostic biomarkers in CRC and correlate with immune infiltrates.
Genetic Features of P. falciparum Parasites Collected in 2012-2016 and Anti-Malaria Resistance Along China-Myanmar Border
Authors: Li Mei , Liu Hui , Tang Linhua , Yang Henglin , Bustos Maria Dorina Geluz , Tu Hong , Ringwald Pascal
Published: September 2020

Backgrounds The therapeutic efficacy studies (TES) of T(DHA-PIP) for uncomplicated P. falciparum patients were implemented during 2012-2016 along China (Yunnan province)-Myanmar border, which verified the high efficacy of DHA-PIP. The study focusing on the genetic features of falciparum parasites and basing on in vivo parasite clearance time (PCT) were carried out to explore if they had produced potential resistance to DHA and PIP at molecular level. Methods The genetic features were investigated based on K13 propeller genotypes, Copy numbers of genes pfPM2 and pfmdr1 and 9 microsatellite loci (Short Tandem Repeats, STR) flanking the K13 gene on chromosome 13. The PCT 50s basing on different K13 genotypes, sites, periods and copy numbers were compared.Results In NW (North-West Yunnan province bordering with Myanmar) area, F446I prevalence was 58.96% (79/134). No significant different PCT 50s presented among 3 K13 groups (Chi-Square=2.35, P=0.31, df=2) classified by K13 genotypes within NW area, but all of them were significantly shorter than that in SW (South-West Yunnan province bordering with Myanmar) area (P=0.036, t=-2.11, df=174) where isolates only showed wild K13 genotype. For the copy numbers of pfmdr1 gene, 14.63% (18/123) and 62.5% (10/16) parasite isolates showed double copies (≥ 1.6) in NW and SW areas separately, but for those of pfM2 gene, no parasite isolates did. Between isolates with single and double copies of pfmdr1 gene, no different PCT 50 presented. According to the mean He values, the four K13 groups were arranged as ML group (Menglian County in SW), F446I group, Others (Non-F446I K13 mutation) group and W (wild K13 genotype) group from low to high. The mean Fst values between ML and W groups were significantly higher than other 2 K13 group-W pairs (Paired-T Test: t=-2.659，df=8，P=0.029; t=-4.966, df=8，P=0.001). Conclusions According to our study, P. falciparum isolates in NW area and SW area are very different in genetic features. Artemisinin partial resistance, inferred from genetic marker, F446I, had independently appeared and spread in NW area during 2012-2016. With global application of ACTs, this pattern of artemisinin resistance producing was worth more attention. Fortunately, PIP-resistant feature basing on genetic analysis showed negative results in both areas. So, DHA-PIP was still recommended in antimalarial treatment along China-Myanmar border based on molecular data, which was agreed with the conclusion drawn from in vivo data obtained with same falciparum isolates. Trial registration: ISRCTN, ISRCTN 11775446. Registered 13 April 2020 - Retrospectively registered, http://www.isrctn.com/ISRCTN11775446.
High Efficiency Refrigeration and Pyroelectric Energy Harvesting Applications of Lead Titanate Based Relaxer Ceramic
Authors: Zhang Tianfu , Huang Xianxiong , Xu Hu , Sun Shujie , Liu Zuodong , Tang Xin-Gui
Published: September 2020

Relaxer ferroelectrics are highly attractive in electrocaloric due to large breakdown electric field and wide phase transition temperatures, which has great potential applications in solid-state cooling. In this work, relaxer ferroelectrics are synthesized by a traditional solid state reaction method. Phase transition and relaxer characteristics are studied by temperature dependent dielectric spectrums. Temperature dependent ferroelectric properties are also studied to calculate electrocaloric effect. Maximum value of refrigeration efficiency η ( ΔT/ΔE ) is about 0.079 K·cm/kV, our result lays a foundation and provides a reference for studying high efficiency solid-state electrocaloric refrigeration. Pyroelectric energy harvesting are studied, maximum pyroelectric energy harvesting is 279 kJ/cm 3 .
II. Vibroloading the operator skidding tractor in acceleration process.
Authors: Александров В.А. , Ву Х.К.
Published: September 2020

Разработана динамическая модель системы «Машинист – трелевочный трактор – пачка деревьев». Математическое описание составлено в форме уравнения Лагранжа 2-го рода. Система дифференциальных уравнений решена относительно упругой деформации подвеса сиденья. Апробация модели осуществлена на примере серийного трелевочного трактора ТБ-1.

In article the dynamic model of system is developed «the operator – skidding tractor tree bunch». The mathematical description is worked out in the form of the eguation of Lagrazha second number. The system of the eguations is solved concerning elastic deformation of the suspension seats. Model approbation is carried out on an exemple of serially skidding tractor TB-1.
Effect of wood thermal modification on cutting power consumption during circular sawing
Authors: Староверов Р.Л. , Шарапов Е.С. , Королев А.С.
Published: September 2020

Статья посвящена изучению энергоемкости процессов продольного и поперечного пиления термически модифицированной древесины сосны (Pinus Sylvestris), березы (Bétula Péndula) и дуба (Quércus Róbur) круглыми пилами. Проведен краткий обзор работ в области изучения процесса пиления древесины круглыми пилами, а также анализ влияния различных факторов на процесс пиления древесины. Входные факторы эксперимента - высота и ширина пропила (мм), скорость подачи (м/мин), потеря массы древесины после термической модификации (%). Разработаны экспериментальная лабораторная установка и измерительный шлейф на основе устройства сбора данных «National Instruments USB-6008». Получены статистически значимые регрессионные модели влияния входных факторов эксперимента на энергоемкость процессов продольного и поперечного пиления термически модифицированной древесины сосны, березы и дуба круглыми пилами. Наблюдается значимое уменьшение энергоемкости процесса пиления древесины круглыми пилами с увеличением интенсивности (потери массы) термической модификации для всех исследуемых пород. Снижение мощности на продольное пиление термически обработанных образцов, в сравнении с необработанной древесиной, составило, в среднем, 14,6 и 25,6% для древесины сосны, 13,3 и 33,2% для древесины березы, 9,5 и 21,8% для древесины дуба при потерях массы соответственно 4 и 8%. Мощность при поперечном пилении термически модифицированных образцов, в сравнении с необработанной древесиной, в среднем, снизилась на 17 и 27% для древесины сосны, на 26 и 46% для древесины березы, на 10 и 17% для древесины дуба при потере массы соответственно 4 и 8%.

The article concerned with the power requirements of longitudinal and transverse circular sawing process of thermally modified pine (Pinus Sylvestris), birch (Bétula Péndula) and Oak (Quércus Róbur). The short review of materials in the field of wood sawing process and effect of some factors on circular sawing are presented. Input factors of the experiment were: depth and width of sawing (mm), feeding speed (m/min) and mass loss of the specimens after thermal modification (%). An experimental laboratory setup and measuring loop on the basis of DAQ-X «National Instruments USB-6008» were developed. Regression models of correlation between input factors and power requirements of longitudinal and transverse round sawing of thermally modified timber (TMT) were received. There is a significant reduction of power consumption of TMT round sawing with increasing the intensity of thermal modification for all wood species. For longitudinal TMT sawing and 4 and 8% of mass loss in comparison with untreated wood averaged decreasing of power requirements were 14.6 and 25.6% for pine, 13.3 and 33.2% for birch, 9.5 and 21.8% for oak. For transverse TMT sawing and 4 and 8% of mass loss in comparison with untreated wood averaged decreasing of power requirements were 17 and 27% for pine, 26 and 46% for birch, 10 and 17% for oak.
Designing the structure of information support of the road transport hauling
Authors: Гусев Ю.В. , Капустин В.П. , Козлов В.Г. , Скрыпников А.В.
Published: September 2020

Рассмотрены общие принципы информационного обеспечения системы лесовозного автомобильного транспорта, а также основы функционирования систем лесовозного автомобильного транспорта и информационного обеспечения. При разработке решений информационного обеспечения определены основные критерии и мероприятия по оптимизации информационного обеспечения систем функционирования лесовозного автомобильного транспорта. Выделены этапы структуры информационного обеспечения. Определено, что главной задачей системы управления информационного обеспечения функционирования лесовозного автомобильного транспорта является достижение максимума некоторого функционала (составленного из отдельных критериев) при определенных ограничениях на выбор управляющих воздействий за счет изменения параметров системы. По результатам исследования сделаны выводы, из которых следует, что нормальное функционирование лесовозного автомобильного транспорта связано со способностью информационного обеспечения системы лесовозного автомобильного транспорта к адаптации в зависимости от изменения конкретных условий, а также определены границы внешней и внутренней среды, установлены два механизма контроля системы управления информационным обеспечением лесовозного автомобильного транспорта.

Deals with the General principles of information support system of timber transportation road transport, as well as the basics of system operation logging of road transport and information provision. When developing solutions for information security defines the basic criteria and measures for optimization of information support systems in the functioning of forest road transport. The stages of the structure of information provision. Determined that the main task of the management system of information support of the functioning of forest road transport is to achieve the maximum of some functional (composed of individual criteria) under certain restrictions on the choice of control actions by changing the system parameters. According to the study findings, which suggests that the normal functioning of the timber-carrying road transport is associated with the ability of the information support system of timber-carrying road transport to adapt depending on changes in specific conditions, but also defined the boundaries of the external and internal environment, are two of the control mechanism of the system control information maintenance hauling road transport.
Especially in the creation of digital terrain models for designing the transport network of multi-purpose forest management
Authors: Громов И.А. , Тюрин Н.А.
Published: September 2020

При проектировании лесной транспортной сети в условиях многоцелевого, непрерывного и неистощительного лесопользования в рамках модели интенсивного лесного хозяйства, необходимо обладать информацией об экономической целесообразности транспортного освоения участков лесной территории. Для решения данной проблемы возможно создание цифровой модели местности (ЦММ), отражающей распределение чистого дохода (ЧД) от освоения лесов по территории объекта проектирования. Создание ЦММ включает в себя четыре этапа: сбор исходной информации; ГИС-анализ; определение ЧД; создание ЦММ в ГИС. На первом этапе осуществляется сбор данных, необходимых для определения значения ЧД и создания модели в ГИС. На втором этапе осуществляется интеграция данных в ГИС, их обработка и анализ с целью получения показателей для определения ЧД. На третьем этапе осуществляется расчет показателя ЧД для каждой первичной единицы транспортного освоения. На завершающем этапе, на базе вычисленных значений ЧД, в ГИС создается тематическая карта, отражающая уровни ЧД. Использование рассматриваемой методики позволяет сформировать ЦММ, которая наглядным образом отражает экономическую целесообразность транспортного освоения участков леса, что является основой для проектирования размещения элементов лесной транспортной сети. Методика создания ЦММ является составной частью более общей методики проектирования транспортной сети в условиях многоцелевого, непрерывного и неистощительного лесопользования.

When designing the forest transport network in terms of multi-purpose, continuous and sustainable forest management in the framework of the model of intensive forest management requires information about the economic feasibility of the transport development in areas of forest land. To solve this problem, it is possible to create digital terrain model (DTM) showing the distribution of net income (NI) the forest areas with the forest transport  network development. The technique of creating DTM includes four stages: collection of baseline information; GIS analysis; determination of the NI; the establishment of the DTM in GIS. The first stage is collecting the data necessary to determine the value NI and create a model in GIS. The second stage involves the integration of data into GIS, their processing and analysis with the aim of obtaining indicators for the determination of NI. In the third stage calculated NI for each primary unit of the transport network development. At the final stage, on the basis of specific values of NI in the GIS generated thematic map reflecting the levels of NI. Using this technique allows to creating DTM which visually reflects the economic feasibility of the transport development forest, what is the basis for the design and layout of the elements of the forest transportation network. The technique of developing ETM is integral part of a more General methodology for the design of the transport network in terms of multi-purpose, continuous and sustainable forest management.
Normal QT interval in Ukrainian Riding Horses at rest and during exercise
Authors: POPADIUK BOHDANA , HOLOPURA SERGIY
Published: September 2020

Measurement of the main parameter of cardiac repolarization, namely QT interval, has a very high diagnostic value in human medicine, since its irregularities may indicate severe life-threatening ventricular tachyarrhythmias. The QT interval may vary not only with heart rate, age, sex, and autonomic tone, but also with horse breeds. Therefore, the description of its reference values for a specific breed is of great importance. The Ukrainian Riding Horse was bred as a show jumping, dressage and three-day eventing breed on the basis of Hanoverian, Thoroughbred and Trakehner stallions and local mares, as well as Hungarian Furioso, Gidran Arab and Nonius mares. Twenty-three horses of the Ukrainian riding breed were included in the study: 8 geldings, 8 mares, and 7 stallions aged 3-11 years. The electrodes for ECG recording were placed according to an adapted base-apex system. The ECG was registered during rest, exercise, and recovery periods. QT intervals were measured from resting to peak exercise levels on the traces of the 2nd lead and plotted against RR intervals. The piecewise regression model was fitted to the data plot. The values of Slope1, Slope2, and RRbend were compared to those of other breeds. The QT/RR relationship was relatively described by the piecewise linear regression model for all sexes (0.95 < r2 < 0.97). The sex of horses of the Ukrainian riding breed had a significant effect on the model. In terms of Slope1, Slope2, and RRbend values, Ukrainian riding horses are closest to Warmbloods, Standardbreds, and Thoroughbreds. The QT interval in horses should be corrected for breed and sex.
QUALIDADE DE PRAÇAS E PARQUES URBANOS PELA PERCEPÇÃO DA POPULAÇÃO
Authors: Nogueira Martins Guilherme , Branco do Nascimento Ana Paula , Lucia Casteli Figueiredo Gallardo Amarilis
Published: September 2020

Os espaços verdes urbanos são áreas provedoras de relevantes serviços ecossistêmicos para a sociedade. Dentre esses destacam-se os serviços ecossistêmicos culturais responsáveis pelo fornecimento de recreação, educação e percepção estética e espiritual, possibilitando a ampliação da qualidade de vida dos cidadãos urbanos. Praças e parques urbanos têm sido destacados na literatura como potenciais áreas verdes na oferta desses serviços ecossistêmicos. A governança ambiental dessas áreas verdes urbanas envolve a qualidade desses espaços, e, se for direcionada à promoção de melhores espaços verdes, infraestruturas e equipamentos pode ampliar as funções sociais e ambientais dessas áreas.  O objetivo deste artigo é avaliar a percepção da população do entorno acerca da qualidade de áreas verdes considerado o potencial intrínseco de oferta de serviços ecossistêmicos. Para tanto, selecionou-se um bairro de Osasco, São Paulo, cidade brasileira que possui várias praças e parques urbanos. As 216 entrevistas com moradores foram analisadas estatisticamente. Os resultados mostram que a população do entorno dessas áreas verdes percebe a importância da qualidade dessas áreas e da sua infraestrutura. Os resultados apontam que praças e parques necessitam de melhorias pelo órgão gestor, embora a população perceba que os parques estão melhor cuidados que as praças. Entende-se que esse mapeamento de percepção das áreas verdes pelos usuários pode representar uma oportunidade para a gestão pública local compreender os anseios da população e permitir que os potenciais serviços ecossistêmicos, principalmente, os culturais possam ser ampliados e desfrutados por um número maior de habitantes do bairro.
PRODUÇÃO E CONFIGURAÇÃO DE CONDOMÍNIOS FECHADOS HORIZONTAIS NA CIDADE DE BELÉM-PARÁ-BR, DÉCADAS DE 1990 e 2000
Authors: Fernandes Guedes Rios Marylu , Lima José Júlio Ferreira
Published: September 2020

A área de expansão de Belém, em particular a Av. Augusto Montenegro, um de seus principais eixos viários, tem sido cenário de profundas transformações espaciais a partir da década de 1990 e principalmente nos anos 2000. A partir da criação demanda por moradias fora do centro urbano, houve forte influência do mercado imobiliário na disseminação do arranjo espacial segregado “condomínios fechados horizontais”. O presente estudo tem como objetivo a análise das condições socioeconômicas e de aspectos regulatórios que tornaram a execução deste “tipo” espacial um produto compatível e potencial à expansão do capital imobiliário naquela área. Analisa-se a configuração urbanística e tipologias residenciais de três condomínios pioneiros no eixo eixo viário mencionado, são verificados os efeitos nestes de regulações federais e municipais e de regulações internas contidas em convenções condominiais. Ao final, são feitas correlações entre o desenho dos condomínios e o que é encontrado ou permitido na cidade aberta, mediante diretrizes vigentes da regulação urbana pública municipal.
PERCEPÇÃO DE PROFISSIONAIS DO DESIGN DE INTERIORES SOBRE MATERIAIS SUSTENTÁVEIS
Authors: Bedran Talissa , Pereira Andréa
Published: September 2020

Esta pesquisa tem como objetivo analisar a compreensão dos profissionais atuantes no design de interiores acerca dos conceitos de sustentabilidade e Materiais Ambientalmente Preferíveis (MAP), além de identificar fatores que influenciam a adoção desses materiais pelos próprios. Para tanto, aplicou-se um questionário aos profissionais que atuam em projetos de design de interiores em Belo Horizonte – MG, presencialmente (no evento CASACOR Minas Gerais 2019) e online. A partir dos resultados do questionário, procedeu-se com uma análise qualitativa e quantitativa dos dados, auxiliada por estatísticas que descrevem a conduta geral do comportamento observado da realidade. A aplicação de questionários aos profissionais de interiores demonstrou uma percepção de baixa oferta de materiais ambientalmente preferíveis no mercado, além de uma baixa divulgação dos mesmos e de um conhecimento técnico insuficiente por parte dos vendedores das lojas as quais frequentam. Também foi observado que a maioria dos respondentes indicaram ser importante a sustentabilidade para o planeta, porém, atribuíram uma importância menor quando questionados às preocupações concernentes à própria área, e um nível ainda menor de utilização de MAP em seus projetos. A análise da relação entre as variáveis, realizada por intermédio da correlação de Spearman, permitiu identificar que a aplicação de MAP teve associação significativa com a familiaridade com conceitos de sustentabilidade, importância atribuída aos conceitos, a aplicação dos conceitos em projetos, a quantidade de informações requisitadas e o montante de informações disponíveis sobre os materiais.