bluuebunny/crossref_metadata_2025 huggingface dataset:
Analysis of the Sustainability of Relations in the Media System as a Small Group
Authors: Kuznetsova Irina
Published: January 2022

In the study of social systems, the issue of establishing and preserving their integrity has a special place. It determines the stability of functioning and development. Organizational behavior plays an important role in the cohesion of work teams, and not only between the performers of the main production, but also the managers and their subordinates. The art of human resource management has not lost its relevance now, but on the contrary, has gained new significance in the environment of rapid technological innovation.
The article analyzed the relations between employees of a small-scale media production team: a manager and two employees. The purpose of the work was a systematic analysis of a finite set of possible relationships between the members of the media production team, including at least three people. A table of combinations of interaction options that form production relations with an indication of the reliability index of functioning was compiled. According to research, in some cases, the creative team functions holistically and productively, and in others it is subject to disintegration.
Studies have shown that when building successful labor relations within an organization, a manager has to consider not only hierarchical structure, but also the human factor.
Efficiency of State Economy Regulation Tools in Contemporary Russia
Authors: Kolodin Viktor , Zaitseva Elizaveta
Published: January 2022

It has now become obvious that market economy is not able to develop successfully without government support. Moreover, state regulation is becoming increasingly important, particularly in the periods of recession. The pandemic of COVID-19 has changed the world and required strengthening the regulatory function of the state. In 2020, the government had to provide for organizing and financing the national health care system, free vaccination and medicines for the public, allowances to families with children and to people on unpaid leaves, as well as subsidies and reduced-rate lending to businesses. The demand for statism – a doctrine that the political authority of the state is the objective and result of social development – is a new trend in the world. Russian economy currently features a slow pace of growth, a lack of private investments, and a decrease of real disposable income. In this context, studies of efficiency of economy regulatory tools used by the state are becoming topical.
The article analyzes the role of the state in the society, determines its functions and objectives, objects and subjects, and describes its administrative and economic regulatory tools. The authors point out the country’s economic problems of the recent decade and estimate the efficiency of the economy regulation tools used by the state.
Energy Inflow into the Magnetosphere and Its Distribution During Magnetic Storm
Authors: Degtyarev Vitalii , Popov George , Chudnenko Svetlana
Published: January 2022

The energy inflow from the solar wind into the magnetosphere and its dissipation in the circular current and auroral ionosphere during maximums of magnetic storm intensity are considered. All magnetic storms with Dst intensities from –18 nT to –422 nT for the period from 1996 to 2014 were divided into groups. For each group, the mean contribution of energy from the solar wind to the magnetosphere and subsequent characteristics of the energy dissipation in the auroral ionosphere and circular current were determined by the superposed epoch analysis method. The nonlinearity of the dependence of the intensity of magnetic storms on the energy coming from the solar wind into the magnetosphere was revealed. Anomalous behavior of magnetic storms with intensity |Dst| > 200 nT was detected. A discussion of the results is given.
Pain and physical activity levels among Rheumatoid Arthritis patients between the ages of 18 to 50 years in South Africa
Authors: Wilkinson Rebecca , Smith Lynn , Ferreira Simone
Published: January 2022

Background: Little epidemiological research on rheumatoid arthritis (RA) has been done in Africa, suggesting that it is an uncommon illness. In rural South Africa, RA has an overall prevalence of 0.07% and a prevalence of 2.5% in urban areas; therefore, it is not as uncommon as perceived by the lack of research. Patient-centred programmes to improve physical function have been lacking and, as a result, the prior assumption was that physical activity should be avoided.
Objectives: To determine pain and physical activity levels among RA patients between the ages of 18 to 50 years in South Africa.
Methods: A combination of two questionnaires were used, namely, the Global Physical Activity Questionnaire (2002) and the Pain Outcomes Questionnaire (2003). The collated questionnaires were distributed by rheumatologists and on social media platforms to RA patients between the ages of 18 to 50 years old living in South Africa. This study had a sample size of 105 participants, with participation occurring through the online Google forms platform.
Results: One hundred and five participants with RA were recruited with an average age of 38±9 years. Most of the participants were females (93.3%). Seventy-two percent of the sample was classified as physically active, where work, leisure and travel activities were considered. No significant correlation between pain and physical activity was evident (r=0.10; p=0.311). Results showed significant correlations between pain and personal grooming (r=0.30; p=0.002), pain and ambulation (r=0.60; p=0.000), and pain and stair climbing (r=0.60; p=0.000).
Conclusion: Physical activity has proven to have multiple benefits for those suffering with RA. In this South African sample of RA patients, the majority were classified as physically active, and pain did not affect the activity levels of the involved participants. This study opens further research questions regarding RA prevalence in South Africa, and the type and intensity of physical activity that would be beneficial for RA.
Предпосылки и основания становления персоналистической антропологии современного экзистенциального анализа: от идеи к практике
Authors: Шумский В.Б. , Уколова Е.М.
Published: January 2022

Современный экзистенциальный анализ как направление психологической науки и практики развивается благодаря диалогу с философией, академической психологией, теоретическими моделями и практическими методами различных школ психотерапии. Имен­но такой диалог в последнее десятилетие привел к существенному развитию представлений о духовном измерении человека, составляющих базис экзистенциально-аналитической антропологии — дифференциации феноменальных проявлений духовного измерения на Я и личность и соответствующей понятийной концептуализации. В на­сто­ящей статье впервые систематизированы развиваемые в последних работах А. Лэнгле представления о духовном Я как центре самосознания, принятий решений, волевой активности человека и духовной личности как центре ориентации в пространстве сущности бытия. Прослеживается преемственность линии развития идеи личности от философской антропологии М. Шелера и психологии поиска смысла В. Франкла к современному экзистенциальному анализу А. Лэнгле. Концепты «духовное Я» и «духовная личность» рассмотрены как феномены человеческого бытия и как теоретические конструкты. Подробно проанализировано теоретико-методологическое значение различения Я и личности для понимания проблемы аутентичности и генеза индивидуальных различий, преодоления абсолютизации психоноэтического антагонизма концепции В. Франкла, раскрытия важности внутреннего диалога в динамике самоотношения и самоосуществления. Обосновано понимание развития человека как становление его духовного Я и способности предоставлять личности пространство возможностей в человеческом бытии, а также понимание психического здоровья, психических расстройств и релевантный подход к разработке стратегии и методики психотерапии. Показаны философско-методологическая и культурно-историческая перспективы развития идеи личности в современном экзистенциальном анализе.
COVID-19 as Industry Forcing Function: Challenges for Entrepreneurship in the Post-Pandemic Future
Authors:   Groningen University, Belousova Olga , Walsh Steven ,   University of New Mexico, Groen Aard ,   Groningen University
Published: January 2022

The COVID-19 crisis has changed how firms and industries do business – at least for now. What is uncertain, however, is the duration of that change. Will the industry change induced by the COVID-19 crisis persist and, if so, for how long? Can a crisis, and particularly the COVID-19 crisis, act as a more permanent change agent and create an environment that mimics the entrepreneurial opportunity that industry forcing functions create? If yes, then there is cause to consider the entrepreneurial opportunity that the COVID-19 crisis provides. In this paper, we review the changes that the pandemic has brought to business practices. Furthermore, we discuss the differences between crisis-based opportunity and entrepreneurial opportunity created by industry forcing functions in order to illuminate the ability of a COVID-19 crisis–induced Low Touch Economy to sustainably create entrepreneurial opportunities. We show examples and list the attributes of industry forcing functions that have already provided sustainable entrepreneurial opportunity. Then, we match these attributes with the factors pertaining to the COVID-19-related Low Touch Economy. We find that the COVID-19 crisis has similarities and differences to the traditional industry forcing functions started by disruptive technologies. However, unlike traditional industry forcing functions, the COVID-19 crisis acts in a pan-industrial manner, making the impact of the pandemic more profound. Furthermore, the timing of the pandemic is important too: the COVID-19 crisis struck during the emergence of a Schumpeterian wave of Industry 4.0 and accelerated the adoption of its most important harbingers. We provide researchers and practitioners a lens through which to review not only the COVID-19 crisis’s possibility of lasting effects, but also how it will affect entrepreneurs.
Generating 1200bp tiled Amplicons for SARS-CoV2 Whole Genome Sequencing v1
Authors: not provided jason.nguyen , Lee Tracy , Hickman Rebecca , Prystajecky Natalie , Tyson John
Published: January 2022

This procedure provides instructions for how to generate amplicons across the entire SARS-CoV-2 genome to be used for downstream whole genome sequencing applications, including Illumina MiSeq/NextSeq or Oxford Nanopore MinION sequencing platforms. The steps involved in this protocol were derived from version 3 of Freed et al protocol nCoV-2019 sequencing protocol (RAPID barcoding, 1200bp amplicon)V.3 available at https://dx.doi.org/10.17504/protocols.io.bgggjttw
Monstrous animal siblings in Europe
Authors: Ermacora Davide
Published: January 2022

Reports of women giving birth to a baby together with an animal (toad, mouse, bird, etc.), are documented in Europe from the 1100s onwards: the most important traditions of which are the frater Salernitanorum and the sooterkin. Throughout the centuries, authors have typically attempted to explain monstrous animal siblings in the light of contemporary medical knowledge. The present paper compares the medieval frater Salernitanorum with the later sooterkin and investigates both in historico-folklore terms. It argues that it is important to understand monstrous birth traditions not only in the light of medical history, but as beliefs and narratives actively shared through acts of communication. In so doing, this article is informed by both the history of medicine and folklore studies.
Evaluation of the Apically Extruded Debris During Canal Preparation by WaveOne Gold, Hyflex EDM and XP-endo Shaper, Anin Vitro Study
Authors: Adnan Marwah , Al-Gharrawi Hikmet
Published: January 2022

Objective: The main cause of this in vitro study was to measure and compare the amount of debris extruded apically using three NiTi single rotary files (primary WaveOne Gold file, Hyflex EDM file, and the XP-endo Shaper).  

Methods: Palatal root of sixty freshly extracted human maxillary molar teeth were sectioned at 12 mm, and inserted through the center of a rubber stopper of a pre-weighed collecting vial except for the coronal quarter of the root. Then separated three groups in accordance with their (n =20) system. G I: primary WaveOne Gold single file system (Dentsply-Maillefer, Ballaigues, Switzerland)., G II: Hyflex EDM single file system (Colten/Whaledent, Germany). and G III: Xp-endo Shaper single file system (FKG, Switzerland) used, the 1mm irrigation with distilled water applied for washing the instruments, apical debris was collected and dried at 100° C. Sequential weights were obtained for each vial, and the distinction between the weights of the vial (pre- instrumentation and post- instrumentation), considered debris weight. Data were analyzed statistically using the One-way ANOVA test and LSD test, p≤ 0.05 was considered for data analysis value.      

Results: All rotary systems applied in this study showed apical extrusion of debris. GIII showed the significantly highest amount of debris (p< 0.001) compared to GI and GII, whereas, mean value differences of Hyflex and WaveOne Gold were statistically non- significant (p>0.05).  

Conclusions: The Hyflex EDM showed the lowest mean value of debris extruded apically compared to WaveOne Gold and Xp-endo Shaper. XP-endo Shaper had the highest mean value of debris extruded apically.
Azoximer bromide-modulated immune response in aerobic vaginitis
Authors: Dikke G. B. , Ostromenskii V. V. , Kucheryavaya Yu. G.
Published: January 2022

Aim: to evaluate the efficacy of azoximer bromide along with a combined antimicrobial drug in treatment of patients with aerobic vaginitis (AV).

Materials and Methods. There was conducted a prospective, randomized, parallel group study with enrolled 60 patients diagnosed with AV and 10 apparently healthy women (control group III). Group I (n = 30) received azoximer bromide (10 vaginal insertion according to the scheme, course of 10 days) and a combined antimicrobial drug, while Group II (n = 30) received only antimicrobial drug (course of 10 days). Microscopy of vaginal discharge smears, polymerase chain reaction method was used, detection of cytokines – interleukins (IL) and tumor necrosis factor-alpha (TNF-α) in vaginal washings was performed by ELISA. The study of neutrophil extracellular traps (NETs) was performed by ELISA, and DNA-containing strands ejected by neutrophils were determined by fluorescence method.

Results. Recovery from disease was found in 100 % (30/30) and 86.7 % (26/30) in group I and group II, respectively. After treatment, serum level of IL-8 was revealed to decline in group I from 35.2 to 5.5 pg/ml (p = 0.05), in group II – from 33.4 to 5.3 pg/ml (p = 0.04), also not differ (p > 0.05) from the control values (5.2 pg/ml). The level of IL-1β also decreased after treatment in group I from 51.5 to 15.1 pg/ml (p = 0.002), in group II – from 57.9 to 20.1 pg/ml (p = 0.03), which also did not differ (p > 0.05) from the control values (16.7 pg/ml). The IL-10 level in both main groups decreased slightly (from 0.26 and 0.24 to 0.16 pg/ml in both groups), which was higher by 1.8-fold than in the control group (0.09 pg/ml; p < 0.001). The number of ejected NETs in both main groups decreased significantly after treatment, reaching control level. No side effects were observed, compliance and acceptability were 100 % in both groups. The frequency of AV relapses within 3 months was observed in 3.3 % (1/30) and 14.3 % (4/28) patients, after 6 months – in 14.3 % (4/28) and in 20.0 % (5/25) patients in groups I and II, respectively. Using the logit regression model, demonstrated that AV relapse might occur with a 50 %-probability at TNF-α level < 0.1 pg/ml after treatment (sensitivity – 67 %, specificity – 79 %). The risk of relapses in group I, in contrast to group II, showed a downward trend.

Conclusions. The use of azoximer bromide and a combined broad-spectrum antimicrobial drug is effective in AV treatment, exerts a modulating effect on immune response parameters contributes to lowering relapse rate.
Antiphospholipid antibodies, genetic thrombophilia and fetal growth retardation
Authors: Orudzhova E. A.
Published: January 2022

Aim: to study the role of antiphospholipid antibodies (AРA) and genetic thrombophilia as a potential cause of the development or a component in the pathogenesis of early and late fetal growth retardation (FGR).

Materials and Methods. There was conducted a prospective randomized controlled trial with 118 women enrolled. The main group consisted of 83 patients, whose pregnancy was complicated by FGR degrees II and III, stratified into two groups: group 1 – 36 pregnant women with early FGR, group 2 – 47 pregnant women with late FGR. Women were subdivided into subgroups according to the FGR severity. The control group consisted of 35 pregnant women with a physiological course of pregnancy. АРА were determined according to the Sydney antiphospholipid syndrome criteria by enzyme immunoassay (ELISA): against cardiolipin, β2 -glycoprotein 1, annexin V, prothrombin, etc. (IgG/IgM isotypes); lupus anticoagulant – by the three-stage method with Russell's viper venom; antithrombin III and protein C levels – by chromogenic method; prothrombin gene polymorphisms G20210A and factor V Leiden – by polymerase chain reaction; homocysteine level – by ELISA.

Results. AРA circulation (medium and high titers), genetic thrombophilic defects and/or hyperhomocysteinemia were detected in 40 (48.2 %) patients with FGR, which was significantly higher than that in the control group (p < 0.05): in group 1 (41.7 % of women) AРA (30.6 %) and AРA with genetic thrombophilia or hyperhomocysteinemia (11.1 %) were revealed; in group 2 (51.1 % of women) AРA (21.3 %), AРA with hyperhomocysteinemia (4.3 %), genetic thrombophilia (25.5 %), and due to hyperhomocysteinemia (2.1 %) were found. No differences in prevalence of thrombophilia rate in patients were observed related to FGR severity, but a correlation between the FGR severity and AРA titers was found.

Conclusion. Testing for the presence of AРA, genetic thrombophilia and hyperhomocysteinemia should be recommended for patients with FGR (including those with FGR in medical history), especially in the case of its early onset. It is recommended to determine the full AРA spectrum.
On the Work of Meshcheryakov (Afterword and Notes
Authors: Ilenkov E.V. , Maidansky A.D.
Published: January 2022

In 1963, a children’s home for the deaf-mute was founded in Zagorsk, near Moscow. Alexander Meshcheryakov, the head of the laboratory at the Institute of Defectology of the Academy of Pedagogical Sciences, became its supervisor. Four years later, Evald Ilyenkov joined the experiment. The archival text “On the work of Meshcheryakov”, published now for the first time, was presented at the Presidium of the USSR Academy of Pedagogical Sciences in February 1973. In this paper, Ilyenkov briefly formulates his conception of psychical image as condensing of a temporal process of activity into a spatial form of object, and suggests a number of deep thoughts on connection of the psyche and language, sign and meaning, word and action, taking his stand on the data of the Zagorsk experiment. The process of image formation is demonstrated by the case “Julia and the ravine”. After a walk along the ravine, a deaf-blind girl was able to mould the contour of the ravine from plasticine. Without seeing the ravine, she reproduced the trajectory of her body’s motion as some spatial object. The formation of language in deaf-blind persons begins with gesture speech, which is gradually transformed into verbal speech — first in its dactyl, then written and, finally, sound form. The experimental study of this transformation helps to solve the question of how speech and language are connected to objective reality.
Legal and Technical Defects of Constitutional Amendments of 2020
Authors: Goleshchikhin V. S.
Published: January 2022

The quality of legal and technical elaboration of amendments to the Constitution of the Russian Federation, approved by the all-Russian vote on July 1, 2020, does not correspond to the level of the Basic Law. Oddly enough, the constitutional legislator ignored a number of basic technical means, rules and methods of legal technique. Thus, the constitutional amendments were drafted without taking into account the requirements of the structural organization of the legal act, namely: many new norms were included in inappropriate articles, the transitional provision on "resetting the deadlines" was duplicated in the main text of the Constitution. The authors of the amendments abandoned criteria of efficiency and compactness of legislative norms, having included an identical set of restrictions in nine articles of the Constitution in relation to various categories of officials. The text does not meet the requirement for uniformity of legal regulation, legal structures, the unity, simplicity and brevity of terminology: the scope of constitutional restrictions for various categories of officials differs somewhat without any objective reasons; there is no uniformity in the issue of the possibility of establishing additional requirements for officials by laws, “bifurcation” of the titles for senators (who in Chapter 9 of the Constitution are still referred to as members of the Federation Council). Insufficient attention to the requirement of consistency of legal norms has led to the creation of a new contradiction between Art. 71 and 72 of the Constitution of the Russian Federation. Amendments also have a number of other legal and technical defects. Such serious and numerous defects in the legal technique of amendments to the Constitution of the Russian Federation became a natural result of a steady decline in the quality of federal legislation that has lasted for a long time. Constitutional amendments clearly demonstrate an insufficient level of legal culture in our country, which sharply raises the question of a radical improvement in the quality of legal technology, and legislative technology in particular.
Effect of ozonotherapy on clinical and immunological indicators in children with allergic rhinitis
Authors: Illek Yan Yurievich , Suetina Irina Gennadievna , Solovieva Galina Vladimirovna , Tarasova Elena Yurievna , Khlebnikova Natalia Vladimirovna , Mishchenko Igor Yurievich , Ryseva Larisa Leonidovna , Leushina Nina Pavlovna , Vyaznikova Marina Leonidovna
Published: January 2022

Objective. To determine the effect of ozonotherapy on the clinical indicators and immunological reactivity state in children with a moderate course of persisting allergic rhinitis.

Materials and methods. Children aged 510 years with a moderate persisting allergic rhinitis were under observation. They were divided into two groups depending on the therapy applied. Group I of allergic rhinitis patients received a complex generally accepted therapy, group II of allergic rhinitis patients a complex therapy associated with ozonotherapy. Clinical indices and immunological reactivity parameters were studied during exacerbation and clinical remission in allergic rhinitis children.

Results. Ozonotherapy, included into a complex treatment of group II patients, was established to promote a faster occurrence of full clinical remission and normalization of most parameters of immunological reactivity. Duration of a full clinical remission in the group of allergic rhinitis patients, who received a complex therapy associated with ozonotherapy, more than twofold exceeded its duration in the group of allergic rhinitis patients receiving a complex generally accepted therapy.

Conclusions. The data obtained indicate high clinical, immunomodulating and antirelapsing effect of ozonotherapy that allows recommending its wide use in complex of medical measures among children with persisting allergic rhinitis.
Peculiarities of karyotype in patients with miscarriage
Authors: Olina A. A. , Sadykova G. K. , Shirinkina E. V.
Published: January 2022

Objective. To study the features of the karyotype in patients with miscarriage. This article is devoted to the role of maternal chromosome polymorphisms and their role in the genesis of miscarriage.

Materials and methods. A comparative assessment of the karyotypes in women, whose pregnancy proceeded without complications and ended in the birth of a healthy child (75 persons, group I), and a group of patients with NB (135 persons, group II) was carried out. Group IIa consisted of 68 women with the first pregnancy that ended in spontaneous abortion in the first trimester, group IIb - 67 women with the first and subsequent pregnancy, interrupted in the first trimester. Statistical processing of the obtained material was carried out using the Exel program, and StatTech v.2.1.0.

Results. A significantly greater number of patients with normal karyotype was in group I 72 persons (98.1 %). Data on the structure of chromosome polymorphisms showed that in patients of group II, changes in one chromosome are found in 8.8 % (3 people), two chromosomes in 23.5 % (8 persons). Analysis of the data of group II showed significant differences in the subgroups in the frequency of chromosome polymorphisms, in patients of group IIa changes were noted only in one chromosome, and in IIc, every fifth patient had polymorphism of two chromosomes.

Conclusion. Despite the fact that genetic breakdowns are uncontrollable factors and it is not possible to directly influence them, the search for possible mechanisms leading to them is promising.
Effect of preoperative atrial fibrillation on long-term results after Off Pump Coronary Artery Bypass
Authors: Enginoev Soslan T. , Kondratiev Dmitriy A. , Magomedov Gasan M. , Rashidova Tamara K. , Kadyraliev Bakytbek K. , Chernov Igor I. , Tarasov Dmitriy G.
Published: January 2022

Objective. To study the effect of preoperative atrial fibrillation (AF) on the risk of stroke and long-term mortality after Off Pump Coronary Artery Bypass (OPCAB).
Materials and methods. A retrospective analysis of the results of OPCAB in 212 patients with coronary artery disease (CAD), who were operated on from May 2009 to November 2013, was carried out. After propensity score matching, patients were divided into 2 groups: Group I 82 patients with sinus rhythm (SR) before surgery, Group II (control) 102 patients with AF before surgery. The average age of the included patients was 61 6.7 years, with 95 % CI: 6062. Fifty-four (29.3 %) patients were over 65 years of age. There were 162 men (88 %) and 22 women (12 %). The median follow-up was 93.5 (66.7102.0) months.
Results. The time spent in the clinic was statistically significantly shorter in the SR group than in the AF group (10 (911) and 14 (1116) hours, respectively, p 0.001). There was no statistically significant difference in the number of perioperative myocardial infarctions (in the group with SR it occurred in 1 (1.2 %) patient, in the group with AF 2 (2 %), p = 0.7), strokes (in the group with SR 1 (1.2 %), in the group with AF 3 (2.9 %), p = 0.6), as well as a 30-day mortality (in the group with SR it was 0 %, in the group with AF 3 (2.9 %), p = 0.2). In the long-term postoperative period, there were statistically significantly fewer strokes in the group with SR than in the group with AF (in the group with SR, the 10-year stroke freedom was 88.8 %, and in the group with AF 71.8 %, p = 0.018), and also better long-term survival in the group with sinus rhythm (in the group with SR, the 10-year survival rate was 79 %, in the group with AF 63.9 %, p = 0.016).
Conclusions. In the group with preoperative AF, the frequency of distant strokes and deaths is higher than in patients with sinus rhythm.
Correlation assessment of gender and thyroid hormones in patients with primary oligomenorhea in anamnesis
Authors: Ibadullaeva-Adygezalova K. P.
Published: January 2022

Objective. To determine the concentration of pituitary, ovarian and thyroid hormones in the blood and the correlation between them in women with a history of primary oligomenorrhea.

Material and methods. The study involved 56 women of reproductive age with primary oligomenorrhea. Control 50 women of fertile age with an undisturbed rhythm of menstruation. An ultrasound of the uterus, ovaries and thyroid gland was performed. Concentrations of luteinizing hormone (LH), follicle stimulating hormone (FSH), prolactin, estradiol, testosterone dehydroepiandrosterone sulfate (DHEA-S), triiodothyronine (T3), thyroxine (T4), thyroid stimulating hormone (TSH) were determined by ELISA.

Results. The average age of women in the main and control groups was 30.0 1.34 and 30.52 5.92 years (p 0.05), respectively. The average age of menarche in women of the main group was 13.27 0.80 years; duration of menstruation 3.4 0.40 days and 5.2 0.82 days (p = 0.051), respectively; duration of the menstrual cycle was 33.90 0.70 days (p = 0.001). Length and width of the uterus 3.99 0.19 cm (p = 0.055) and 4.51 0.11 cm, respectively; endometrial thickness 9.78 1.20 mm. The sizes of thyroid lobes did not differ between the groups. The LH level and the LH / FSH ratio were higher than the control values by 50.79 % (p = 0.052) and 52.66 % (p = 0.045), respectively. Testosterone and TSH concentrations were 38.33 and 34.36 % higher, respectively. The estradiol level was reduced by 56.67 % (p = 0.113). A weak correlation was revealed between sex and thyroid hormones.

Conclusions. In women with a history of primary oligomenorrhea, the concentration of luteini-zing hormone and the LH / FSH ratio in the blood serum are significantly higher (p 0.05). In women with primary oligomenorrhea, there was a weak correlation between sex and thyroid hormones. The results will provide insight into the relationship between the thyroid function and the menstrual cycle.
Role of interactive survey in early diagnosis of chronic kidney diseases
Authors: Burtseva Ekaterina Alekseevna , Mishlanov Vitaly Yurievich , Anikeeva Anna Vladimirovna , Selezneva Victoria Ivanovna , Koshurnikova Ekaterina Petrovna , Chugainov Sergey Vladimirovich
Published: January 2022

Objective. To conduct a comparative study of the prevalence of specific symptoms in patients with kidney damage using the automated program "Electronic Polyclinic" to optimize the algorithm for early diagnosis of chronic kidney disease.

Materials and methods. 18 patients of the therapeutic unit with kidney lesions, confirmed by laboratory and instrumental studies, as well as 7 healthy persons were examined. The main problems of patients were identified by the method of interactive questioning with the help of the program "Electronic Polyclinic". Further, a statistical analysis of the data and a comparative study with the control group of healthy persons were carried out using STATISTICA 12.0 program.

Results. The main symptoms of kidney damage were reliably determined and a low sensitivity of individual symptoms in the diagnosis, in contrast to the syndromic approach, was revealed. It showed that in 100 % of cases the automated program "Electronic Polyclinic" detected the syndromes, that indicates its high efficiency. An algorithm for early diagnosis of chronic kidney disease was proposed, which consists in an initial interactive survey followed by examination formulated by the computer program.

Conclusions. The method of interactive survey using the automated program "Electronic Polyclinic" allows you to effectively identify the syndromes of kidney damage, makes a preliminary diagnosis and draws up a plan of examination for further confirmation of the diagnosis. Symptomatic diagnosis has a number of disadvantages including low sensitivity and specificity, so it yields to syndromic diagnosis.
In Vivo Studies of the ERK1/2 Phosphatase, MKP3 in Dopaminergic Neurons on Gene Expression, Dopamine Signaling and Cocaine-Associated Behaviors
Authors:   , Lewandowski Stacia Irene , Barker Jacqueline M , Mortensen Ole V
Published: January 2022

Cocaine use disorder is a chronic and debilitating disease with no FDA-approved pharmacotherapies for treatment. Cocaine exerts its addictive effects by blocking the dopamine transporter (DAT), leading to excess dopamine (DA) in the synaptic cleft, resulting in the euphoric "high" that is often sought-after during addiction. The ERK1/2 Map Kinase signaling pathway has been implicated in the stimulant effects of psychostimulants such as cocaine. However, limitations exist in these previous studies as they were based on systemic or local administration of kinase inhibitors and thus lack the anatomical specificity that is needed for a more detailed investigation of the role of ERK1/2 signaling in specific cell types. Here we describe the modulation of the ERK1/2 pathway in vivo by expressing the ERK1/2 phosphatase MKP3 in DA neurons of the ventral tegmental area (VTA) of Long Evans rats, resulting in a decrease of ERK1/2 signaling specifically in these neurons. We demonstrate that DA neuron specific ERK1/2 inhibition differentially affects high (HCRs) and low (LCRs) cocaine responding animals. This classification is based upon their acute locomotor response to cocaine. Specifically, we find that MKP3 expression and resulting ERK1/2 inhibition only affects HCRs, and we demonstrate that MKP3-expressing HCRs more closely resemble LCRs at both the behavioral locomotor response to cocaine and the DAT protein level. We hypothesize that this results from MKP3's role in regulating intracellular DAT trafficking and surface expression. Furthermore, this is supported by functional studies of the DAT where we demonstrate that inhibition of ERK1/2 signaling in DA neurons influences DA neurotransmission in the nucleus accumbens (NAc) and that the DAT in MKP3-overexpressing animals is resistant to dynamic regulation of its surface expression. Finally, studies utilizing Viral Translating Ribosomal Affinity Purification (vTRAP) and resulting RNA-Seq data demonstrate upregulation of several genes including dopaminergic genes, such as tyrosine hydroxylase and the DAT, which has been further confirmed also to occur on the protein level. We think these studies have established a unique model to understand and identify factors involved in regulating DA neuron activity and associated behaviors and could have potential for identifying novel therapeutic targets for the treatment of cocaine use disorders.
COVİD-19 PANDEMİSİ SÜRECİNDE ÖĞRETMENLERİN UZAKTAN EĞİTİME İLİŞKİN ÖZ-YETERLİK ALGILARI
Authors: ÇOK Cemal , GÜNBATAR Mustafa Serkan
Published: January 2022

Covid-19 pandemisiyle beraber tüm dünyada olduğu gibi ülkemizde de zorunlu olarak uzaktan eğitime geçilmiştir. Bu çalışma, 2020-2021 eğitim öğretim yılı uzaktan eğitime mecburi ve hızlı geçiş süreci ile birlikte öğretmenlerin uzaktan eğitime ilişkin öz-yeterlik algılarını ortaya çıkarmayı amaçlamaktadır. Örneklem grubu, Van ili Millî Eğitim Bakanlığına bağlı ilk ve orta dereceli okullarda görev yapan 381 öğretmenden oluşmaktadır. Öğretmenlerin uzaktan eğitime ilişkin öz-yeterlik (UEÖY) algılarını ortaya çıkarmak için çalışma kapsamında 36 maddeden oluşan bir ölçek geliştirilmiştir. Yapılan analizler sonucunda UEÖY ölçeği beş alt faktörden oluşmuştur. Ölçeğin tamamına ilişkin Cronbach’s Alpha Güvenirlik katsayısı .966, Teknik Öz-yeterlik alt boyutu .934, Öğretimsel İçerik Öz-yeterlik alt boyutu .910, Öğretimde Teknoloji Kullanımı Öz-yeterlik alt boyutu .936, Uzaktan Eğitim Yazılımsal Öz-yeterlik alt boyutu .915, Duygusal İletişim Öz-yeterlik alt boyutunun .828 bulunmuştur. Analizler sonucunda elde edilen bulgulara bakıldığında öğretmenlerin uzaktan eğitime ilişkin öz-yeterlik algıları cinsiyet, çalıştıkları öğretim kademesi ve uzaktan eğitimde EBA platformunu kullanıp kullanmama değişkenleri açısından anlamlı farklılık göstermemektedir. Branş, mesleki çalışma süresi, uzaktan eğitimle ilgili bir eğitim alıp almama ve uzaktan eğitimde ZOOM platformunu kullanıp kullanmama değişkenleri açısından ise anlamlı farklılık görülmüştür. Elde edilen sonuçlardan yola çıkarak öneriler sunulmuştur.
Giving feedback in the new CBME curriculum paradigm: Principles, models and situations where feedback can be given
Authors: Chacko Thomas V
Published: January 2022

The new competency based medical education represents a paradigm shift from a teacher centered to a student centered learning of outcome competencies paradigm and so both the students and the teachers are unfamiliar with it. Giving and receiving feedback is central to the competency development framework. Only through frequent, timely and appropriate feedback there will be effective development of cognitive competence in its lead up to performance of competence. These concepts are illustrated to convey the importance of giving feedback to students.

As the teachers are expected to practice giving feedback to students, they were opportunistically asked prior to a faculty development workshop what their priority learning needs about giving feedback are. Based on this a focused review of literature was done to collect the information on the various models of giving feedback, the principles for giving feedback, the possible situations in curriculum delivery where teachers can and should give feedback to students.

The literature revealed some good practice models for giving feedback to the naïve as well as the mature students in ambulatory and clinical teaching settings as well as on their performance as revealed by their test results. Models of counseling which has strong element of feedback on the learner’s performance and helping them choose the way forward after identifying the problem is also shared.
El uso de aplicaciones móviles en el aprendizaje de las matemáticas: una revisión sistemática
Authors: Rodríguez-Cubillo María del Rosario , Del Castillo Héctor , Arteaga Martínez Blanca
Published: January 2022

El uso de aplicaciones móviles educativas en las aulas se proyecta como una herramienta para mejorar el rendimiento en matemáticas. El objetivo del presente trabajo es realizar una revisión sistemática centrada en los beneficios que su uso puede aportar en la adquisición de la competencia matemática temprana. Se ha realizado una revisión sistemática de la literatura publicada en bases de datos nacionales e internacionales, desde enero 2015. Los datos se han clasificado dando lugar a una descripción de estas aplicaciones móviles. Los resultados iniciales facilitaron 1329 referencias, identificando únicamente 25 de estos estudios dentro de los criterios de inclusión prefijados. La mayoría de las evidencias informan de un impacto positivo tras el uso de las aplicaciones móviles educativas en el aula, tanto en el rendimiento y la motivación como en las actitudes de aprendizaje de los estudiantes en el área de matemáticas.
US footprint transformation in Iraq and Bagdad regime’s sustainability prospects
Authors: Yevseenko Andrey
Published: January 2022

U.S. withdrawal from “forever wars” doesn't mean the complete drawdown of U.S. footprint in the Gulf region. That’s one reason why Iraqi political regime won't be toppled. The United States is going to minimize its military presence as well as make it safe for its military personnel. Nevertheless, the U.S. footprint in the Middle East is transforming and adapting for U.S. competition with “revisionist powers.” The United States intends to use their traditional foreign policy toolbox in this struggle. All typical U.S. foreign policy deficiencies, such as absence of the strategic approach, incoherence and lack of foresight, remain. Therefore, all key U.S. issues, which were set on Iraqi direction, will stay unresolved. Their scope and urgency will be contained by objective regional factors and limited U.S. competitors’ potential, not by American influence.
US “Relentless diplomacy” and the Outlook of the regulation of the Israeli-Palestine conflict
Authors: Tsaregorodtseva Galina
Published: January 2022

Article is devoted to American-Israeli relations due to the announcement of Biden’s administration new foreign policy based on “relentless diplomacy” as well as the US pursuit to consider future solution of the Israeli-Palestinian conflict in two “peoples-two states” concept.
Hydrophobic Properties of CuO Thin Films Obtained by Sol-Gel Spin Coating Technique-Annealing Temperature Effect
Authors: Bougharouat Ali , Touka Nassim , Talbi Dalila , Baddari Kamel
Published: January 2022

The adhesive characteristics of sol-gel copper oxide (CuO) film surfaces at annealing temperatures ranging from 350 to 550°C were examined in this work. Hydrophobic properties of these oxide film surfaces were studied by contact angle measurements. The surface energy was calculated from contact angle data using harmonic mean method. The structural, morphological and chemical analysis of the samples were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and Fourier transform infrared (FTIR). The increase in annealing temperature induces a reduction in the hydrophilic properties of the films (adhesive properties). The rise in the hydrophobicity of the CuO surface has been claimed to be explained by a change in interfacial tension. The FTIR spectroscopy analysis revealed that the increase in the annealing temperature eliminates activated neutral species (hydroxyl groups) reacting with the surface of the sample responsible for the wettability. SEM analysis showed that the morphology of the samples is nanostructured containing agglomerates of various forms, a few hundred nanometers in size, randomly dispersed across the surface. The enhanced roughness of the produced film is primarily responsible for the increased hydrophobicity of the films. The XRD data reveal that the films are highly textured and that increasing the annealing temperature induces better layer crystallization and confirms the development of copper oxide CuO.
Lateral scanning logging while drilling data processing using convolutional neural networks
Authors: Danilovskii K. N. , N. Loginov G.
Published: January 2022

This article discusses a new approach to processing lateral scanning logging while drilling data based on a combination of three-dimensional numerical modeling and convolutional neural networks. We prepared dataset for training neural networks. Dataset contains realistic synthetic resistivity images and geoelectric layer boundary layouts, obtained based on true values of their spatial orientation parameters. Using convolutional neural networks two algorithms have been developed and programmatically implemented: suppression of random noise and detection of layer boundaries on the resistivity images. The developed algorithms allow fast and accurate processing of large amounts of data, while, due to the absence of full-connection layers in the neural networks’ architectures, it is possible to process resistivity images of arbitrary length.
Проблемы экологии как объект художественного осмысления в осетинской детской литературе (на материале повести В.Гаглоева «О чем плакал горный родник»)
Authors: Бритаева А.Б.
Published: January 2022

На материале сказки-повести В. Гаглоева «О чем плакал горный родник» рассматривается художественное отображение экологических проблемы в осетинской детской литературе. Акцент делается на многослойности идейного содержания, а также на использовании автором образов-символов. Актуальность статьи обусловлена не изученностью жанра повести в осетинской детской литературе.
Основные цветообозначения в осетинском языке
Authors: Дзахова В.Т. , Кайтукова С.И.
Published: January 2022

В статье на основании критериев определения основных цветообозначений, сформулированных Б. Берлином и П. Кейом, анализируются цветообозначения осетинского языка. Привлекая к анализу данные этимологического словаря, а также частотность употребления, делается вывод о наличии в современном осетинском языке четырех основных цветообозначения.
Национально-культурная специфика паремичных единиц в рамках антиномии «умглупость» (на материале русского и чешского языков)
Authors: Кандыбина А.В.
Published: January 2022

В работе представлена характеристика семантических особенностей русских и чешских паремий в рамках антиномии «ум–глупость». Описаны единицы с ядерным компонентом «религиозные представления». Установлены общие и специфические черты отражения национального менталитета в семантике пословично-поговорочных выражений сравниваемых языков.
Особенности письменной молодёжной речи в социальных сетях и мессенджерах
Authors: Корнякова Т.А. , Яриков В.Г.
Published: January 2022

Современный русский язык подвергается постоянным изменениям. Как правило, именно молодёжь вызывает эти изменения. Как общение в социальных сетях и мессенджерах влияет на русский язык? Какие тенденции существуют на сегодняшний день? Это мы и рассмотрим в нашей статье.
Трансформация образа в переводе женского образа в произведении Лао Шэ «Рикша»
Authors: Ордахова Т.В. , Тарасова К.Р.
Published: January 2022

В данном исследовании проводится анализ перевода женского образа Ху Ню в произведении Лао Шэ «Рикша». Китайский язык, в силу иероглифической письменности, изобилует различными своего рода омофонами и игрой слов. При переводе художественного произведения необходимо не только передать стилистическую окраску и смысл содержания, но и попытаться передать культурный колорит, языковые особенности.
Концентрированные растворы в аптечной технологии
Authors: Багаев Д.А.
Published: January 2022

В современных условиях производственная аптека — рациональное и экономически выгодное звено в организации лечебного процесса. Основная ее задача — наиболее полное, доступное и своевременное удовлетворение потребностей стационарных больных в лекарственных средствах, дезинфекционных растворах, перевязочных материалах и т.д. Неотъемлемым элементом полноты и доступности лекарственной помощи является наличие в аптеках, помимо готовых лекарственных средств, экстемпоральных лекарственных форм. В основном это лекарственные средства, которые не производятся фармпредприятиями.
Роль родительского сообщества в реализации спортивного сценария формирования человеческого капитала в Республике Хакасия и прилегающих территориях
Authors: Ибрагимов Р.Н. , Маганаков М.Н.
Published: January 2022

В современной редакции теории человеческого капитала объектом инвестиций могут служить любые способности и таланты человека, в том числе успехи в спорте. В виталистской парадигме главным фактором в деятельности индивида, в динамике развития целых регионов и стран является пассионарность. При этом спорт – это наиболее простая и естественная форма выражения пассионарности. В статье представлены результаты эмпирического исследования отношения родителей региона Республики Хакасия и юга Красноярского края к занятию спортом их детей, а также теоретико-методологические основания к постановке проблемы. Подтвержденной в исследовании базовой гипотезой служили предположения 1) о преобладающем витально-иррациональном характере родительского попечения; 2) о повышенном уровне пассионарности, жертвенности отношения родителей к детям-спортсменам; 3) о повышенном социогенетическом потенциале родительского сообщества.
Интенсификация значимости технического образования в современной образовательной системе России: за и против
Authors: Качан Ю.Д. , Положенкова Е.Ю.
Published: January 2022

В статье рассмотрены основные проблемы высшей школы, касаемые значимости технического образования. В рамках исследования был проведен опрос среди обучающихся технического факультета и сделаны соответствующие выводы.
Особенности прикладных политологических исследований и их научная значимость
Authors: Телятник Т.Е.
Published: January 2022

В статье говорится об особенностях организации прикладных политологических исследований и их значимости для современной науки. Автор статьи говорит о неразрывной связи теоретического и практического аспекта развития политологии, и обращает внимание на структуру и этапы проведения исследования.