bluuebunny/crossref_metadata_2025 huggingface dataset:
Procedural Forms of Protection of the Right to Entrepreneurship in Administrative Courts: Problems of a Scientific Approach
Authors: Rіabchenko Vasyl
Published: July 2023

The topicality is due to the active development of the system of administrative proceedings and at the same time the need to take into account the specifics of the mentioned cases (increased requirements for the promptness of the case review; the accuracy of the definition of individual elements of procedural forms; the need for the administrative court to apply special knowledge in the field of economics). The purpose of the article is to reveal a scientific approach to the development of procedural forms of protection of the right to entrepreneurship in administrative courts, to determine, on the basis of this, the vectors of further development of procedural forms of protection of the specified right. Achieving the outlined goal became possible thanks to the use of a complex of methods of both general scientific and specifically legal nature. Thus, with the use of the formal-dogmatic method, the content of the applied concepts and categories was clarified, including such concepts as "proceedings", "administrative proceedings", "procedural form". The dialectical method made it possible to take into account the general principles of the development of the administrative justice system. On the basis of the combination of this method and the method of synthesis, the current problems of the studied procedural forms are summarized. These and other research methods are applied taking into account the requirements of scientific objectivity. The problem of the ratio of the ratio of the specific procedures for consideration of certain categories of administrative cases and the general forms of legal proceedings is revealed from the standpoint of the dichotomy of the legal nature of the activity of the administrative court (declarative and interventional). Accordingly, the contentiousness of the issue regarding the possibility of calling such specific procedures procedural forms of review and resolution by the administrative court of the considered category of cases was determined. Based on the results of the research, conclusions were formulated and recommendations were made regarding the development of a generalized concept of "procedural form", which would combine the common features of general legal proceedings and simplified legal proceedings in this category of cases. This will make it possible to conduct a further study of the specified common features using a single legal construction.
The Strength of the Deed of Deposit for Electronic Contract Conducted by Notary in Electronic System Implementation in Indonesia
Authors: Aljabar Senna , Prihatinah Tri , Handayani Sri
Published: July 2023

The notary has an authority to certify deeds and has other authorities. Notary products, in the form of deed of deposit, function to rewrite contracts made by persons who have been verified by Electronic System Operators, that the electronic certificates of the parties are indeed authorized to sign the electronic contract and provide guarantees that the contract has actually been made on their platform so that physical (printed) evidence of the electronic agreement made by the parties can be printed through and verified in advance by the service provider electronic system operator. This paper aims to analyze the validity of deed of deposit ("van depot" deed) made by a notary on electronic contracts in the implementation of electronic systems in Indonesia. The research method used is normative, with using secondary data obtained from library research, including primary, secondary, and tertiary legal sources. Whereas the deed of deposit or "van depot" deed is an certified deed made by a notary for the authority he has in making certified deeds. The deed of deposit or "van depot" deed provides the storage of a document that is kept by a notary, which furthermore explains in the deed of deposit that the applicant orders to the notary to keep a document, which is owned or given to him so the document will be more secure. The authority of a Notary in making certified deeds in the case of a deed of deposit or "van depot" deed of Electronic Contracts allows a synergy between the Law of Electronic Information and Transactions, Legal Products and Notary Legal Products in the future. Based on the authority of the Notary in making the deed of deposit or "van depot" deed for the electronic contract, what is the form of the deed of deposit or "van depot" deed for the electronic contract. Which title of the Deed must be used: "Deed of Deposit of Electronic Contract" or "van depot" Deed of Electronic Contract"?
Updated Grounds for Filing a Cassation Appeal: Constitutional Limitation or Constitutional Violation?
Authors: Shestopal Kira
Published: July 2023

The relevance of the topic is due to the fact that the latest judicial reform has provoked a considerable influence on procedural relations and caused a number of problems for legal practitioners. The development of the main theoretical provisions took place since the 70s of the last century. In these studies, considerable attention was always paid to the procedural possibilities of applying to the court of first instance. At the same time, since the restoration of Ukrainian statehood, scientists have researched the value, limits of powers and, in general, the status of the Supreme Court in Ukraine. Ukraine has gone through many judicial reforms, most of which related to the courts of first instance and appeals. The main novelty, of the latest judicial reform, to which attention is paid in the article, is the updated grounds for filing a cassation appeal. Ukraine has declared a European course and adds all efforts to become part of the European family. That is why the latest judicial reform, which introduced these novellas, was carried out in the context of the European course. At the same time, the legal regulation of the possibility of applying to the court of cassation, actually restrict the constitutional rights and freedoms of a citizen, does not meet the standards announced in the decisions of the Constitutional Court of Ukraine and in the European standards, which became the main problem. The purpose of the article is to study the working documents that accompanied the relevant bills on amendments to the Constitution of Ukraine on justice, decisions of the Constitutional Court of Ukraine, the Supreme Court, as well as decisions of the European Court of Human Rights (hereinafter – the ECHR). The achievement of the outlined goal became possible due to the use of a set of methods of information analysis and synthesis. The article highlights and analyzes the working documents that accompanied the constitutional amendments on justice, the decisions of the Constitutional Court of Ukraine and the Supreme Court, the practice of the European Court of Human Rights, with the aim of identifying substantive disagreements and shortcomings. It is emphasized that the changes (at the constitutional and legislative level) actually restrict the content and scope of rights and freedoms, regarding the possibility of cassation appeal of court decisions, which were guaranteed by the Constitution of Ukraine and do not meet the principle of legal certainty. Based on the results of the study, conclusions were formulated and recommendations were made on the implementation of the right to appeal to the court of cassation.
Liability for Violation of the Duty of Care and Upbringing in the Criminal Code of the Federal Republic of Germany
Authors: Zaytsev Oleksiy , Pavshuk Kateryna
Published: July 2023

The relevance of the topic of research is determined by the fact that the problem of non-fulfillment or improper fulfillment by parents (persons who replace them) of childcare responsibilities exists in all countries, regardless of the form of government, state system and income level of the population. Ukraine is in the process of integration with the European Union, so it is useful to study the foreign legislative approach to regulating responsibility for the violation of these obligations. The aim of the article is to study the German experience of establishing criminal liability for non-fulfillment of childcare obligations. Dogmatic, systemic-structural, statistical, historical-legal, formal-legal research methods were used in the research. Attention is paid to German legislation, which provides for the right and duty of parents to care for and bring up children. The genesis of the criminal law regarding the liability for violation of these duties is given. Statistical data on the number of criminal proceedings and persons convicted of this criminal offense (2010–2021) are summarized. The peculiarities of the structure of the crime provided for in § 171 of the Criminal Code of the Federal Republic of Germany have been studied; objective and subjective characteristics. The analysis was carried out on the basis of the doctrine of German criminal law and the practice of courts of general jurisdiction, in particular the Federal Supreme Court of Germany. The practice of the Federal Constitutional Court of Germany was used. Based on the study, conclusions were formulated regarding the definition of: the legal interest that is protected; signs of "gross" violation of duties; criteria for establishing the consequence of the crime, which is provided as the tort of creating danger. The peculiarities of the qualification of the crime in case of its commission in a place where an armed conflict is taking place are noted. The allocation of an independent structural section (subsection) in the Criminal Code of Ukraine, which includes criminal offenses against family, is supported. The discussion of the criminalization of harm caused by a crime provided by Art. 166 of the Criminal Code of Ukraine, creating a real threat (danger) of causing harm to the victim is proposed.
Classification of Electronic (Digital) Traces of Criminal Offenses
Authors: Kovalenko Artem
Published: July 2023

With the further development of science and technology, the ways in which offenders use electronic computing devices while committing criminal acts are also changing. Each new method, each manifestation of illegal technology leaves behind specific traces, which in most cases are new for both theorists and practitioners. Identification, extraction and examination of each type of such traces requires unique approaches. Therefore, the task of forensic scientists is to divide the mentioned traces into varieties based on their essential and forensically significant features in order to further develop practical recommendations for working with them. Therefore, the purpose of this article is the formation of a forensic classification of electronic (digital) traces of a criminal offense. To achieve the goal, the methods of generalization, linguistic analysis, formal-legal, formal-logical, comparison, forecasting, analysis and synthesis methods, as well as activity and praxeological approaches in forensic science were used. The author singled out forensically significant features of electronic (digital) traces of a criminal offense and selected three groups of criteria for their classification: according to the features of the trace-forming object, according to the features of computer data as a trace, and according to the features of the carrier (media) of such data (trace-receiving object). Based on the first group of criteria electronic (digital) traces of a criminal offense are divided into varieties according to the trace-forming object; based on the second group of criteria – according to data formatting, according to data content, according to the method of information perception, according to data authenticity, according to the possibility of access; based on the third group – according to the location of the computer data carrier (media), according to the purpose and type of installation of the carrier and by the energy dependence of the storage device of the data carrier. In the author's opinion, scientific research on the further distribution of electronic (digital) traces of criminal offenses into subtypes and the formulation of practically oriented recommendations regarding their detection, collection, examination and use in criminal proceedings are promising.
Features of the course of the early neonatal period in newborns from mothers who underwent COVID-19 during pregnancy (pilot prospective cohort study)
Authors: Betz Olga G. , Kornilov Arsen A. , Khmelevskaya Irina G.
Published: July 2023

Objective: analysis of the course of the early neonatal period in newborns from mothers who underwent COVID-19 at different gestation periods. Materials and methods. Full-term children under the age of 7 days of life born in the Regional Perinatal Center of Kursk in 2021 were under observation: group 1 - as a result of pregnancy complicated by COVID-19 infection (47 people); group 2 - control group (31 people). The main indicator of the study is the pathological nature of the course of the early neonatal period. Results. The anthropometric data at birth did not differ significantly. Transient neonatal tachypnea (19.1% in group 1 versus 9.6% in group 2, respectively), intrauterine pneumonia (19.1% in group 1 versus 3.2% in group 2, respectively; both had bilateral p values = 0.040) were detected more frequently in newborn infants. Conclusion. COVID-19 infection during pregnancy was found to be a risk factor for the development of respiratory disorders in newborns in the early neonatal period. When interpreting these data, the limitations of the study should be taken into account: the sample size, the observational nature of the study, and the methods used to measure the indicators.
Features of intracardiac hemodynamics in patients with acute myocardial infarction with st segment elevation who underwent COVID-19
Authors: Mikhin Vadim P. , Gindler Anna I. , Zaikina Natalya V. , Zaikina Margarita P. , Nikolenko Tamara A. , Savelyeva Valentina V. , Chernyatina Marina A. , Aleksandrov Anton M.
Published: July 2023

Objective: to evaluate the features of central and intracardiac hemodynamics in patients with ST-segment elevation myocardial infarction (STEMI), who underwent COVID-19 during inpatient stay and 6 months after the development of STEMI. Materials and methods. 140 patients with STEMI were included in the study. The patients were randomized into 2 groups: I - main group - patients with STEMI who suffered COVID-19 (52 people) in the period from 1.5-6 months before the development of acute coronary syndrome (ACS), II - comparison group (88 people) which included patients with STEMI who did not have COVID-19 in the anamnesis. All patients underwent PCI with stenting of the infarct-related artery in the first 24 hours from the onset of ACS. The parameters of central and intracardiac hemodynamics in all patients were determined for 2-3 days (1st control point), 9-11 days (2nd control point), after 6 months (3rd control point) from the moment of hospitalization for STEMI. Results. In the patients of the main group of the study, more pronounced changes in the systolic-diastolic LV function were recorded on the 2-3 day of STEMI: LV EF by 8.5%, Sm by 7.2% and E' by 24.5% (p<0.05) were lower than in the control group, respectively, E/E' by 11.5% and WMSI by 21.8% (p<0.05) were higher than in the comparison group. On the 9th-11th day of the disease in patients with STEMI who underwent COVID-19, a slowdown in the recovery of the studied parameters was revealed: the LV EF value was lower than in the control group by 11%, Sm by 12% and E' by 20% (p<0.05), respectively, and the value of E/E' by 27% and WMSI by 25% (p<0.05) were higher than in the comparison group. 6 months after STEMI, there were no significant differences in Sm, E', E/E' values in the main and control groups, however, a lower LVEF and WMSI value was noted in comparison with the control group (p<0.05). Conclusion. Unidirectional positive dynamics of systolic-diastolic function parameters in hospital and post-hospital follow-up periods was observed in patients with STEMI, both those who had COVID-19 and without COVID-19 in the anamnesis. However, in patients who underwent COVID-19, there were more pronounced violations of LV systolic-diastolic function on 2-3 days and less pronounced, delayed positive dynamics of these parameters during the hospital and post-hospital treatment periods.
Phenotypic approach to personalization of pharmacotherapy in patients with congenetive heart failure with low left ventricular ejection fraction
Authors: Povetkin Sergey V.
Published: July 2023

Objective is to present a review of the literature data concerning the personalization of pharmacotherapy in patients with chronic heart failure with low left ventricular ejection fraction. The article discusses modern approaches to phenotyping patients with chronic heart failure with a low left ventricular ejection fraction (HFrEF). Various criteria of phenotyping are considered, both technologically complex and having the prospect of implementation into real practice in the future, and currently being implemented. For the current period, the most acceptable approach from a practical point of view remains the phenotyping of patients with HFrEF, based on clinical, hemodynamic parameters, which allows prioritizing the appointment of medicines. The article discusses the choice of optimal classes of drugs that affect the prognosis of patients with HFrEF, based on taking into account such markers as blood pressure, heart rate, presence of atrial fibrillation, presence and degree of renal dysfunction, electrolyte balance, a combination of these parameters. A phenotypic approach to the treatment of patients with HFrEF will help to ensure the personalization of pharmacotherapy for heart failure with maximum benefit for a particular patient.
Pathophysiological aspects of dental hyperesthesia and ways to eliminate it in elderly patients after a new coronavirus infection COVID-19
Authors: Shvetsov Mikhail M. , Bobyntsev Igor I. , Iordanishvili Andrey K.
Published: July 2023

Currently, there is no scientifically substantiated information on the occurrence of dental hyperesthesia and its causes in patients who have undergone a new coronavirus infection COVID-19. Objective: to study the occurrence of dental hyperesthesia, to analyze the causes and to find ways to eliminate it in elderly patients after a new coronavirus infection COVID-19. Material and methods. The incidence of dental hyperesthesia was studied in 175 elderly people (from 61 to 75 years old) who had a new coronavirus infection COVID-19 2-4 months ago. As a control group, 125 elderly people were examined, who had not suffered from a new COVID-19 coronavirus infection before their examination. Functional resistance of hard tissues of teeth was assessed using the index of enamel resistance test (TER-test) according to V.R. Okushko and oral hygiene using the simplified index of oral hygiene of Green-Vermillion OHI-S. Results. It has been established that in the postcovid period, dental hyperesthesia is more common in elderly patients, the cause of which is the demineralization of tooth enamel due to the deterioration of individual oral hygiene. Generally accepted oral hygiene in elderly people suffering from dental hyperesthesia contributes to the normalization of the TER-test indicators with a period of 3 to 6 months of regular dental and oral care. The additional use of remineralizing ASEPTА gel for teeth by patients during dental care made it possible to achieve high structural and functional resistance of tooth enamel during the quarter. Conclusion. In people who have undergone a new coronavirus infection COVID-19, due to the deterioration of the hygienic condition of the oral cavity, there is a decrease in the mineralization of hard tooth tissues, which is a factor in the occurrence of dental hyperesthesia and confirms the crystal chemical theory of this pathology. The additional use of remineralizing ASEPTА dental gel for individual dental and oral care makes it possible to achieve high caries resistance of tooth enamel in a shorter time.
Dynamics of water temperature and interfacial heat flux in lake ice and under-ice layers
Authors: Huo Jingbo , Shi Xiaohong , Zhao Shengnan , Sun Biao , Li Guohua , Yu Haifeng , Wang Shihuan
Published: July 2023

The purpose of this study is to understand the temperature dynamics of ice and lake water under ice during ice growth. A vertical temperature monitoring system for ice and water under ice was employed for the first time in Wuliangsuhai Lake from 20 December 2016 to 15 March 2017 to obtain continuous monitoring temperature data necessary for calculating the heat flux density at the ice–water interface. During the ice growth period, the ice body temperature and the water body temperature under the ice show an obvious rising trend from the upper layer to the lower layer. As the ice body enters the melting period, the ice temperature and the water temperature under the ice begin to change rapidly. In the presence of snow over the ice, the fluctuations of ice temperature and water temperature under the ice remain stable. According to the experimental data, the analytical equation derived from the Stefan condition is used to calculate the heat flux at the intersection boundary of ice body and water body under ice, which varies from 1.73 to 19.6 W/m2. The dynamic change of ice thickness is significantly influenced by the temperature of ice and water and the heat flux density at the ice–water interface.
FILOSOFAR COM ARTE
Authors: De Oliveira Joilson
Published: July 2023

Escrever sobre a relação entre arte e filosofia representa um esforço para construir uma possibilidade de avançar na compreensão e intercecção dessas duas maneiras distintas de produzir conhecimento e sentido,  refletindo sobre com a imaginação artistica e o pensamento filosófico.Para tanto, alguns filósofos contemporâneos, principalmente Jean Paul Sartre e Gaston Bachelard são evocados no intuito de referenciarem formas de conceber tal relação entre imagem e pensamento de modo diversos, embora favoreçam a compreensaão dessa tentativa de encontrar um caminho viável na perspectiva de se cogitar Filosofar com arte,pressupondo uma pótica da imaginação pensante.
EQUAÇÃO CIVILIZATÓRIA DISCUTIDA NO PROCESSO EDUCATIVO POR MEIO DA TRANSDISCIPLINARIDADE
Authors: Melz Elisângela Regina Selli , Meireles Juliane Conceição , Aviz Alan Silva , Costa Rodrigo Cardoso
Published: July 2023

Diante dos desafios para o aprimoramento do processo educativo atual, bem como da necessidade de provocar uma visão crítica sobre questões cruciais da sociedade, sobretudo das mudanças promovidas pelo avanço tecnológico, nos cabe indagar: quais são os meios que poderiam propiciar ao aluno um entendimento mais claro sobre Ciência, Tecnologia e Sociedade (CTS)? Seria possível promover discussões sobre equação civilizatória por meio de um projeto transdisciplinar? Diante desses desafios que perpassam o processo de ensino, o artigo em questão pretende apontar as perspectivas transdisciplinares como sendo um dos caminhos para discorrer sobre os temas que envolvem a contemporaneidade e, sobretudo, para compreender a equação civilizatória e suas variáveis contemporâneas. Para isso, os apontamentos se darão como resultado de uma pesquisa de revisão bibliográfica e epistemológica que busca sobrepor os limites da disciplinaridade, bem como propiciar um caminho para o processo formativo e educativo de discentes, primando por uma educação mais crítica e reflexiva. Para tanto, à guisa de considerações finais trará projetos e ações educativas que podem ser vislumbradas acerca da transdisciplinaridade, buscando em suas discussões, questões acerca da equação civilizatória.
HORIZONTE DIALÉTICO DA TEORIA CRÍTICA
Authors: Rocha Cleidson de Jesus , Cordeiro Batista Adamor , Carioca de Albuquerque Oliveira Grassinete
Published: July 2023

O presente artigo tem por objetivo refletir teoricamente sobre os desenvolvimentos da teoria crítica a partir da perspectiva frankfurtiana, cujos desdobramentos alcançam, hodiernamente, a ecologia dos saberes e a pedagogia decolonial. Pretende-se fazer a diferenciação entre teoria tradicional e teoria crítica, em suas marcas mais comuns, delimitando o horizonte da gênese até seus prolongamentos, a partir da abordagem sobre o fazer científico e de como a ciência sofre as interveniências dos interesses de classe, a partir da definição de seu método e atitudes de seus pesquisadores. Por ser uma análise teórica, busca-se apresentar a influência da teoria crítica em alguns autores vinculados ao movimento decolonial, que seguem questionando a posição de uma ciência pretensamente hegemônica e exigem novas atitudes e ações articuladas com a ciência comprometida com o processo de decolonização do pensamento e dos corpos. O trabalho se apoia na pesquisa bibliográfica de autores como Horkheimer (1990), Adorno e Horkheimer (1985), Santos (2018), Walsh (2013) e Fleck (2013), demonstrando o lastro do pensamento crítico que, partindo da tradição frankfurtiana, ganha novos contornos com base emancipatória a partir da inserção dos debates decoloniais, que, no limite, visam construir condições de possibilidades de uma nova postura frente a ciência e aos grupos historicamente silenciados.
AUTOBIOGRAFIA FILOSÓFICA EM JEAN-JACQUES ROUSSEAU E FRIEDRICH NIETZSCHE
Authors: Pinheiro Silva Leonice da Conceição , De Castro Freitas Flávio Luiz , Da Silva Façanha Luciano
Published: July 2023

O objetivo central deste trabalho consiste na investigação acerca da relação entre o pensamento filosófico e a escrita de si nos autores Jean-Jacques Rousseau e Friedrich Nietzsche. Para tal, analisam-se as seguintes obras centrais: “Os devaneios do caminhante solitário” (1782) de Rousseau, e o “Ecce Homo” (1888) de Nietzsche. Nas obras citadas percebe-se algo além de uma subjetividade individual, com diferentes nuances e objetivos, mas, a sagacidade de refletir no interior do discurso filosófico, questões sobre o Eu e o mundo exterior. Rousseau deixa-se arrastar pela corrente de sensações, recordações e imaginação, faz de seus devaneios uma técnica de vida e escrita. A busca pelo Eu, o isolamento, possui um rigor metódico, busca a verdade e transparência, onde a vida em sociedade não permite. Semelhantemente constituição paradoxal, ocorre com a autobiografia de Nietzsche, seus aforismos últimos, perpassam o caráter autobiográfico, eles são um trabalho genealógico onde ele analisa a sociedade a partir da escrita de si. Para o processo metodológico utilizou-se a pesquisa qualitativa e bibliográfica, prezou-se pela organização do discurso demonstrativo dos autores, quais suas ideias centrais acerca do referido debate e seus pressupostos.
USO DE RECURSOS DIDÁTICOS E TECNOLÓGICOS COMO MEDIADORES DO PROCESSO DE APRENDIZAGEM NA ALFABETIZAÇÃO
Authors: AURELIANO FRANCISCA EDILMA BRAGA SOARES , PEREIRA BATISTA STEFANY
Published: July 2023

Este artigo relata uma pesquisa desenvolvida no Laboratório de Práticas Pedagógicas (LAPPED) da XXXX (XXXX) que teve como objetivo analisar as possibilidades de mediação da aprendizagem dos alunos em processo de alfabetização de uma Escola Pública do Município de XXXX-XX, pelo uso dos recursos didáticos e das novas ferramentas digitais. O estudo segue as orientações da metodologia da pesquisa qualitativa (MINAYO, 2002), com aprofundamento na análise da ação didática de duas professoras que lecionam no 1º e 2º ano do ensino fundamental. A pesquisa teve como etapa inicial a revisão da literatura sobre recursos didáticos, mediação da aprendizagem e alfabetização a partir dos estudos de Piaget (1976), Vygotsky (1988), Moreira (1999), Souza (2007), Gomes (2017) e Soares (2003). Em seguida foi realizada a pesquisa empírica, por meio da qual acessou-se aos dados, com observações registradas em Diário de Campo, um questionário para caracterização dos sujeitos e entrevista. Empregou-se o procedimento de Análise de Conteúdo de Bardin (1977) para análise dos dados. Os resultados consolidados expressam que as professoras reconhecem que os recursos didáticos e as ferramentas tecnológicas tornam as aulas mais significativas. Nesse sentido, o uso dos recursos didáticos se mostra importante no processo de aprendizagem na alfabetização, pois são instrumentos que irão auxiliar no desenvolvimento de atividades motivadoras.
AQUISIÇÃO DE LIBRAS PARA OUVINTES COMO SEGUNDA LÍNGUA NO ÂMBITO HOSPITALAR
Authors: Pires Bezerra Alaenny , Gadelha Dias Francisca Edivania
Published: July 2023

O artigo discute a aquisição da Língua Brasileira de Sinais (LIBRAS) no âmbito hospitalar. Sendo aplicada no âmbito da formação superior, no ensino técnico e regulares, como uma segunda língua, em prol dos profissionais de saúde, com o intuito de abrangência na qualidade de atendimento ao público e principalmente garantindo espaço à acessibilidade para os pacientes Surdos. O tópico comunicação, configura a necessidade em garantir os direitos para os cidadãos Surdos, pois sua manifestação estará eliminando características de exclusão, desconforto e preconceito presentes na sociedade. O foco no meio hospitalar é devido à deficiência no atendimento na área da saúde ao qual é de cunho importante oferecido como um serviço social. Sugerindo a inclusão da Libras para o meio hospitalar, dará iniciativas para melhor estudar o processo da comunicação da Língua de Sinais. É de caráter indutivo que as gestões da saúde possam promover a abordagem desse problema na educação de forma contínua assim atendendo às demandas educacionais. Ao introduzir este ajuste, pretende-se melhorar a recepção, romper raízes discriminatórias, ademais da igualdade a equidade, ou seja, além de trazer o tratamento de forma igualitária a todos, também adaptá-las às necessidades tornando mais justo o que a comunidade surda necessita. A análise dos dados bibliográficos baseadoS em menções de autores sobre o tratamento adequado oferecido ao sujeito Surdo e o comportamento na comunicação do profissional hospitalar, que poderá melhorar e prevenir riscos à vida. Contudo, usar a preparação da aquisição como uma segunda língua, foram as principais fontes de coleta deste estudo.
CONSTITUINDO AS BASES PARA UMA ANÁLISE DIALÓGICA DO DISCURSO POLÍTICO
Authors: Souza Fábio Marques de , Reis Melo Filipe , Garcia Nogueira Silvia
Published: July 2023

Este artigo apresenta um recorte do embasamento teórico a respeito da Teoria Dialógica da Linguagem do Círculo de Bakhtin, que foi constituído para a realização de uma pesquisa em andamento a respeito do Discurso da Política Externa Brasileira durante o primeiro ano do governo Jair Messias Bolsonaro (2019). A pesquisa tem como objetivo geral analisar o discurso materializado em diferentes gêneros discursivos, desdobrando-se nos objetivos específicos de referendar o contexto sociopolítico dos enunciados concretos e analisar os fios ideológicos que constituem tais enunciados. A Teoria Dialógica da Linguagem do Círculo de Bakhtin tem um lugar consolidado na história do pensamento linguístico. Os autores apresentam as orientações analíticas que serão utilizadas para a compreensão do discurso político em cena, que são importantes para realizar a descrição, análise e interpretação complexa e integrada dos enunciados concretos selecionados para a investigação. A discussão dos três focos de estudos da Análise Dialógica do Discurso – relações dialógicas, gêneros do discurso e formas da língua – contribui para a compreensão de como esses elementos estão interligados e como podem influenciar a compreensão do discurso político.
Experimental Animal Models for Preclinical Investigation of the Bladder
Cancer
Authors: El Khatib Sami , Krayem Maha , Khaled Sanaa , Ayoub Abeer , Salla Mohamed
Published: July 2023

The current treatments for bladder cancer are unable to substantially avoid the disease's growth and recurrence, which is a serious public health
problem. Researchers have explored a variety of approaches in an effort to effectively replicate the pathophysiology of human tumors using
experimental tumor models. The investigation of the available models is a necessary tool in order to choose the most appropriate scheme which
serves the translation of potential treatments from a primary experimental bench to the clinical settings. The most suitable murine models of
bladder cancer should have excellent reproductivity, intravesical predictability, and accessibility in order to facilitate the mechanistic, chemopreventive,
and therapeutic research that can be expanded into clinical trials. This article provides a complete evaluation of both in vitro and in vivo
bladder cancer models, comparing their advantages and limitations in urological research.
CircRNAs as a Novel Class of Potential Diagnostic Biomarkers in
Bipolar Disorders
Authors: Asemi Reza , Ebrahimi Amrollah , Hamblin Michael R. , Mirzaei Hamed , Asemi Zatollah
Published: July 2023

:

Bipolar disorder (BD) is a severe mood disorder with uncertain causes and debilitating
signs and symptoms. Gene expression is crucial to the pathophysiology of BD
and could be influenced by genetic or epigenetic factors, by either direct modification of
mRNA templates or by regulation of post-transcriptional translation. Recent evidence
has shown that several critical processes in psychiatric diseases, such as neuronal activity
or plasticity, synaptic transmission, and neuronal depolarization, have all been linked to
circular RNAs (circRNAs). The circRNA profile of neuronal cells, which may be easily
ascertained by a liquid biopsy, may shed light on the molecular pathophysiology of
psychiatric disorders, including BD. This approach could aid in future development in diagnosis
and treatment. In this review, we provide an in-depth understanding of the roles
of circRNAs in the pathophysiology of BD and offer new insight into their potential as
emerging diagnostic tools and therapeutic targets.
Structure Elucidation and Identification of Novel Lead Molecules against
Sulfur Import Protein cysA of Mycobacterium tuberculosis
Authors: Badineni Mounika , Malkhed Vasavi , Rumandla Lavanya , Malikanti Ramesh , Vadija Rajender , Mustyala Kiran Kumar
Published: July 2023

Aims:

The present work considers the Sulphate import ABC transporter protein (cysA)
as a potential drug target for the identification of inhibitors for the protein.

Background:

The ABC (ATP binding cassette) transporters play a crucial role in the survival and
virulence of Mycobacterium tuberculosis by the acquisition of micronutrients from host tissue.

Objectives:

The 3D structural features of the cysA protein are built. Molecular scaffolds are identified
by implementing active site identification, ADME properties, Virtual Screening, and a few
other computational techniques.

Method:

The theoretical model of cysA is predicted using homology modeling protocols, and the
structure is validated by various validation methods. The prediction of partial dimer formation
through protein-protein docking methods gave insight into the conformational changes taking place
in the cysA protein. The natural substrate ATP is docked with cysA protein that confirms the ATP
binding site. To find the drug-like compounds, virtual screening studies were carried out around
the active site by several ligand databases.

Result:

The findings demonstrate the significance of residues SER41, GLY42, ARG50, GLN85,
HIS86, LYS91, ARG142, and ASP161 in drug-target interactions. The docking studies of existing
TB drugs against cysA were also performed. The result analysis shows that none of the existing
drugs inhibits the ATP active site, which confirms cysA as a promising drug target. Using in-silico
methods, the ADME parameters of a few chosen ligand molecules are predicted and contrasted
with the ADME characteristics of the available TB medications.

Conclusion:

The results revealed the values of ADME parameters of selected ligand molecules are
more permissible than existing TB drugs, which emphasizes the drug-like activity of ligand
molecules by inhibition of cysA proteins. The structural data, active site information, and selected
ligand molecules help in the identification of new therapeutic scaffolds for Tuberculosis.
Lung Cancer Detection from CT Images: Modified Adaptive Threshold
Segmentation with Support Vector Machines and Artificial Neural Network
Classifier
Authors: S. Nair Sneha , Meena Devi V. N. , Bhasi Saju
Published: July 2023

Background:

The most difficult aspect of diagnosing lung cancer is early diagnosis. According to the American Cancer Society, each year, there are around 11 million newly diagnosed instances of cancer worldwide. Radiologists often turn to Computed Tomography (CT) scans to diagnose respiratory conditions, which can reveal if lung tissue remains normal or abnormal. However, there is an increased chance of inaccuracy and delay; therefore, radiologists are concerned with the physical segmentation of nodules.

Objective:

The objective of the research is to implement an advanced modified threshold segmentation and classification model for early and accurate detection of lung cancer from CT images.

Methods:

Using the Support Vector Machines (SVM) classifier as well as the Artificial Neural Network (ANN) classifier, the authors propose using Modified adaptive threshold segmentation as a segmentation approach for cancer detection. Here, Lung Image Database Consortium (LIDC) datasets, a collection of CT scans, are used as the video frames in an investigation to authorize the recitation of the suggested technique.

Results:

Both quantitative as well as qualitative analyses are used to analyze the segmentation function of the anticipated algorithm. Both the ANN and SVM classifiers used in the suggested technique for lung cancer diagnosis achieve world-record levels of accuracy, with the former achieving a 96.3% detection rate and the latter a 97% rate of accuracy.

Conclusion:

This innovation may have a major impact on the worldwide rate of lung cancer rate due to its ability to detect lung tumors in their earliest stages when they are most amenable to being avoided and treated. This method is useful because it provides more information and facilitates quick, precise decision-making for doctors diagnosing lung cancer in their patients.
In silico Evaluation of Ferulic Acid Based Multifunctional Conjugates as
Potential Drug Candidates
Authors: Al-Btoush Hayat A. , Al-Sha'er Mahmoud A.
Published: July 2023

Background:

Recent research has shown that ferulic acid (FA, trans-4-hydroxy-3-
methoxycinnamic acid) has remarkable antioxidant properties and a wide range of biological activities.
Conjugation of two or more biologically active compounds to produce a novel molecular scaffold
is justified by the need to enhance biological activity against a single target or obtain a conjugate
that behaves as a multi-target-directed ligand. In addition, the conjugation strategy decreases
dose-dependent side effects by promoting the use of smaller doses of conjugated components to treat
the disease. Moreover, the patient's compliance is positively affected when conjugating two active
compounds into a single more active compound as this reduces the number of pills to be taken daily.

Objective:

This study aims to shed light on studies that design and synthesize FA-based hybrid compounds
with enhanced biological activities and to in silico assess these compounds as potential drug
candidates.

Methods:

The conjugate compounds were found by searching the literature using the keywords
(ferulic acid-based hybrid or ferulic acid-based conjugate). To study conjugate pharmacokinetic parameters
and toxicity (ADMET), software suites from Biovia Inc. (San Diego, California) were integrated
into Discovery Studio 4.5. The structures were created using ChemDraw Ultra 7.0.

Results:

14 conjugates exhibiting variable biological activities were collected and three of them
(compounds 3,5, and 6) in addition to the cis FA (compound 12) are the best-predicted compounds
with low Daphnia toxicity and hepatotoxicity with acceptable pharmacokinetic properties.

Conclusion:

Cis FA, FA conjugates 3,5, and 6 act as good drug candidates that can be used to modify
new hits.
Use of Mesenchymal Stem Cells in Experimental Ovarian Damage
Authors: Fouad Hanan , Albahlol Ibrahim A , Wahab Hazim A. , Nadwa Eman H , Galal Heba M. , Abouelkheir Mohamed , Taha Ahmed E. , Kamel Abdelkarim G. , Abdelmawlla Hassan A.
Published: July 2023

Background:

Bisphenol-A (BPA) has a well-proven deleterious effect on the hypothalamicpituitary-
gonadal axis.

Objectives:

The current study investigated the therapeutic potentials of mesenchymal stem cells (MSCs)
in a murine model of BPA-induced ovarian damage.

Methods:

Fifty adult female rats were divided into: Group 1; control group, Group IIa, IIb: rats were given
oral gavage of BPA (25 and 50 mg/Kg body weight respectively) on a daily basis for 15 days, and
Group IIIa, IIIb; rats were intravenously treated with of MSCs (106 cells) after receiving the last dose of
BPA as in group II. Plasma and ovarian tissue levels of Malondialdehyde (MDA) and gonadal axis hormones
were assessed. Apoptosis was evaluated by TUNNEL assay and by apoptosis markers (FAS,
FASL, Caspase 3, SLTM). A histological examination of ovarian tissue was also conducted.

Results:

BPA resulted in a significant elevation in plasma levels of LH, FSH, and ovarian tissue levels of
MDA and a significant decrease in estradiol and progesterone. All genetic and protein markers of apoptosis
were elevated in BPA treated group with decreased oestrogen receptor expression in the ovarian tissue.
Increased apoptotic cells were confirmed by TUNEL assay. A high dose of BPA was able to increase the
number of atretic follicles in the ovarian tissue whereas the numbers of primordial, primary, secondary
and Graafian follicles were decreased. All the laboratory and histological abnormalities were ameliorated
by treatment with MSCs.

Conclusion:

The antioxidant and anti-apoptotic effects of MSCs could possibly explain the ability of this
therapeutic modality to ameliorate BPA-induced-ovarian damage.
An Energy-saving Data Transmission Approach based on Migrating
Virtual Machine Technology to Cloud Computing
Authors: Shaker Reddy Pundru Chandra , Sucharitha Yadala
Published: July 2023

Introduction:

Over the past few years, researchers have greatly focused on increasing
the electrical efficiency of large computer systems. Virtual machine (VM) migration helps data
centers keep their pages' content updated on a regular basis, which speeds up the time it takes to
access data. Offline VM migration is best accomplished by sharing memory without requiring
any downtime.

Objective:

The objective of the paper was to reduce energy consumption and deploy a unique
green computing architecture. The proposed virtual machine is transferred from one host to another
through dynamic mobility.

Methodology:

The proposed technique migrates the maximally loaded virtual machine to the
least loaded active node, while maintaining the performance and energy efficiency of the data
centers. Taking into account the cloud environment, the use of electricity could continue to be
critical. These large uses of electricity by the internet information facilities that maintain computing
capacity are becoming another major concern. Another way to reduce resource use is to
relocate the VM.

Results:

Using a non-linear forecasting approach, the research presents improved decentralized
virtual machine migration (IDVMM) that could mitigate electricity consumption in cloud information
warehouses. It minimizes violations of support agreements in a relatively small number
of all displaced cases and improves the efficiency of resources.

Conclusion:

The proposed approach further develops two thresholds to divide overloaded hosts
into massively overloaded hosts, moderately overloaded hosts, and lightly overloaded hosts. The
migration decision of VMs in all stages pursues the goal of reducing the energy consumption of
the network during the migration process. Given ten months of data, actual demand tracing is
done through PlanetLab and then assessed using a cloud service.
Três ou quatro crianças: entre a infância e o sujeito lírico
Authors: Roriz Paloma
Published: July 2023

The article proposes to think about theoretical aspects of the association between chil-dhood and the elaboration of the modern lyrical subject and its implications for understanding the idea of poetic emotion. To this end, the text presents a brief journey of figurations of the child as they emer-ged with German romanticism, passing through Baudelaire, Winnicott and René Schérer, to finally read the figure of the child as incorporated by the poetics of the Portuguese writer Ruy Belo.
Traduzir uma parte/na outra parte: as paisagens poéticas, o ser contemporâneo e a metáfora viva
Authors: Silva Danielle Castro da , Feitosa Márcia Manir Miguel
Published: July 2023

This study seeks to examine how Ferreira Gullar manifests himself as a poetic subject, through literary landscapes built metaphorically, as a contemporary poet who reveals his fractures around the issue of exile. The article aims to analyze the construction of living metaphors in Na Vertigem do Dia. For this, it starts from a phenomenological look, considering its poetic experience, which reveals the poetic subject meeting with him in sameness and ipseity, in line with Ricœur’s ideas, that presentes metaphors as an extension of the senses in the reconfiguration of human time by the verb.
Quantum and Component Analysis of P3a and P3b from Auditory Single Trial ERPs Differentiates Borderline Personality Disorder from Schizophrenia
Authors: Melkonian Dmitriy , Korner Anthony , Meares Russell , Harris Anthony
Published: July 2023

Traditional approaches to EEG modelling use the methods of classical physics to reconstruct scalp potentials in terms of explicit physical models of cortical neuron ensembles. The principal difficulty with such approaches is that the multiplicity of cellular processes, with an intricate array of deterministic and random influencing factors, prevents the creation of consistent biophysical parameter sets. An original, empirically testable solution has been achieved in our previous studies by a radical departure from the deterministic equations of classical physics to the probabilistic reasoning of quantum mechanics. This crucial step relocates the models of elementary bioelectric sources of EEG signals from the cellular to the molecular level where ions are considered as elementary sources of electricity. The rationale is that, despite dramatic differences in cellular machineries, statistical factors governed by the rules of the central limit theorem produce the EEG waveform as a statistical aggregate of the synchronized activity of multiple microscale sources. Based on these innovations, we introduce a method of comprehensive computerized analysis of event related potentials directly from single trial recordings. This method provides a universal model of single trial ERP components in both frequency and time domains. For the first time, this tool provides effective quantification of all significant cognitive components in single trial ERPs and represents a viable alternative to the traditional method of averaging. We demonstrate the clinical significance of the additional information provided by the new method, using ERP data from patients with borderline personality disorder and schizophrenia. Referring to the P300 as an important objective marker of psychiatric disorders, we show that the new method reliably identifies P3a and P3b as the major components of the P3. The diagnostic significance of differentiating the P3a and P3b components of P3 is that it provides an objective electrophysiological measure that distinguishes borderline personality disorder from schizophrenia.