bluuebunny/crossref_metadata_2025 huggingface dataset:
Brogdon, Blackness and the BSI: Archiving race in Sherlock Holmes fandom
Authors: McClellan Ann
Published: December 2021

Philip R. Brogdon is an avid Sherlock Holmes aficionado and the first Black American ever inducted into the exclusive – and predominantly White – Sherlock Holmes society, the Baker Street Irregulars. His small monograph, Sherlock in Black (1995), brings a wealth of archival information and insight into the Black history of Sherlock Holmes fandom, ranging from famous fans of colour to Black fan creators and a history of both professional and amateur fan art, film and music. This article argues that Brogdon’s Sherlock in Black archive provides an important counter-history to White establishment fan narratives popularized by the Baker Street Irregulars and raises important questions about the roles race and identity play in collecting, fandom and identity. How does Brogdon define Black Sherlockian fandom? What did it mean to him, and to other fans, to see this long history of Black Sherlockians in American film and media? What kinds of activities and creations are included? Brogdon’s Black Sherlock Holmes archive illuminates how fans of colour construct their own fan identities and how they see themselves in relation to large, often primarily White, cultural constructs.
Fannish boy: Examining blues fandom through British music periodicals
Authors: Munshower Alan , Johnson Greg
Published: December 2021

Before online forums and social media groups allowed spaces for blues fans to share their love of the music, newsletters and periodicals created by blues societies and fans provided outlets for blues aficionados to connect with other fans, discographers, musicians and scholars through performance and album reviews, pilgrimage storytelling, descriptions of recent discoveries of rare sound recordings and much more. The University of Mississippi Blues Archive holds a large collection of blues periodicals, covering over 1000 unique titles, from over 25 countries, with a bulk date of 1963 to the present. Historically of interest to researchers of blues performance history, the collection also contains a wealth of insight to blues fandom and communities of music appreciation worldwide. This article explores pathways for examining blues fandom studies through the newsletter collection and highlights unique issues and perspectives found in the collection.
Institutional collection profiles
Authors: Brombley Kate , Ammidown Stephen , Lippert Andrew , Fliss William , Brett Jeremy
Published: December 2021

Performing research in fan studies, or any other discipline, is difficult if not impossible without access to documentary collections of primary historical documents, including manuscript material, fannish creations such as fanzines, fanvids and filksongs, correspondence, and ephemera. There are a number of institutions across the world that hold these sorts of collections, and here we provide information about a selected few of those open to scholarly research.
evolución de las imágenes del coronavirus en los informativos de las televisiones españolas y su relación con las imágenes científicas del virus
Authors: López-Díez Jaime , Bonales Daimiel Gema , Jim´énez Gómez Isidro , García Ramos Francisco José
Published: December 2021

El objetivo principal del presente estudio ha sido analizar las características de la representación del virus SARS-CoV-2 en los informativos de las televisiones españolas y su evolución, así como su relación con las imágenes científicas en las que se han basado. Para ello se ha estudiado una muestra de imágenes de los informativos de cuatro cadenas (RTVE, Antena TV, La Sexta y Cuatro) en 2020 y 2021, en las que la imagen del virus estuviera presente en los fondos de los informativos. Asimismo, se han analizado las imágenes del SARS-CoV-2 publicadas en las páginas web de dos instituciones científicas, el CDC y el NIAID. Los resultados muestran las televisiones siguen utilizando predominantemente imágenes en 3D y se observa una tendencia al uso de un único virión. Asimismo, se constata una convergencia funcional entre imágenes científicas y mediáticas, que se refleja en la manipulación cromática de los registros técnicos obtenidos por microscopía electrónica, por parte de los creadores de las primeras. El estudio contribuye a la investigación sobre el imaginario visual de las pandemias, así como a demostrar los límites cada vez más difusos entre imágenes científicas y comunicativas.
P014 Postoperative Recurrence in Crohn’s Disease Patients Treated with Adalimumab versus Infliximab: A Systematic Review and Meta-Analysis
Authors: Frankl Luke , Tarakji Ahmad , Akiyama Shintaro , Hennawi Hussam , Levy Alexander , Hamdeh Shadi
Published: December 2021

BACKGROUND:

Up to 80% of patients with Crohn’s disease (CD) undergo intestinal resection at one point. However, the risk of post-operative recurrence (POR) increases with time, with half of these patients developing recurrence at five years after surgery. Treatment with anti-tumor necrosis factor (anti-TNF) agents has been shown to decrease the risk of clinical and endoscopic recurrence post-operatively. This meta-analysis aims to compare the rate of the two mostly commonly used anti-TNF agents (infliximab (IFX) and adalimumab (ADA)) and their efficacy in maintaining clinical and endoscopic remission in CD patients who were treated with adalimumab versus infliximab after surgery.

METHODS:

A comprehensive search of Medline, EMBASE, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews and Scopus was conducted from each database’s inception to May 29th 2021. Comparative studies assessing the efficacy and safety of infliximab and adalimumab for postoperative CD patients were included. Primary outcomes included postoperative clinical and endoscopic remission. Secondary outcome was the risk of adverse events due to anti-TNF agents. Pooled event rates were calculated per person-year of follow-up.

RESULTS:

Four studies with total of 361 CD patients were included in the final analysis. Our meta-analysis showed no statistically significant difference in maintaining clinical and endoscopic remission rates between patients treated with infliximab and those with adalimumab (Pooled incidence rate ratio of 0.75 (95% CI 0.43–1.3), and 0.94 (95% CI 0.71–1.2), respectively) (Figure 1A, 2A). There were low to moderate heterogeneities (I2 = 57.1% for clinical remission and I2 = 0% for endoscopic remission). The funnel plot in each analysis indicated no publication bias, which was supported by Begg’s and Egger’s tests (Figure 1B, 2B). There was also no significant difference in the risk of adverse events between the two groups (RR= 0.56, 95% CI 0.068–4.5) (Figure 3).

CONCLUSION:

Our meta-analysis demonstrated comparable efficacy of infliximab and adalimumab in maintaining post-operative clinical and endoscopic remission in Crohn’s disease, with similar rates of adverse events. Our meta-analysis was limited by the small number of total studies and patients included and the lack of randomized controlled trials.
P022 Biologic Therapy and Therapeutic Drug Monitoring in Patients With Inflammatory Bowel Disease and Primary Sclerosing Cholangitis
Authors: Jain Varun , Behm Brian , Figueroa Esteban
Published: December 2021

BACKGROUND:

Primary sclerosing cholangitis (PSC) is associated with inflammatory bowel disease (IBD). Patients with concomitant PSC-IBD are at higher risk for IBD-related complications including dysplasia and malignancy, however the typical clinical IBD course is less severe. The aim of this study was to identify the prevalence of biologic use and therapeutic drug monitoring (TDM) in a cohort of PSC-IBD patients.

METHODS:

Retrospective analysis of patients with PSC-IBD on biologic therapy who underwent TDM from Jan. 2018 to Aug. 2020 at the University of Virginia. Demographic data including age, disease duration, and comorbidities were recorded. IBD categorizations were recorded according to the Montreal Classification. Treatment outcomes including therapy changes after TDM were obtained.

RESULTS:

A total of 157 patients with PSC-IBD were identified. Of these, 29 patients (19%) were treated with biologic therapy during the study period. 13 patients underwent reactive TDM due to primary or secondary loss of response and one patient underwent proactive TDM during the study period. Median duration of IBD in this group was 9 years, and the median duration of concomitant PSC-IBD was 5.8 years. 20 TDM tests were obtained in these 14 total patients. Sub-therapeutic drug levels were found in 12 tests among 8 patients, and 3 showed detectable anti-drug antibodies. 8 showed appropriate trough levels. TDM resulted in a change to IBD therapy (i.e., dose escalation, change in biologic therapy used, or addition of IBD medication) in 17 out of 20 tests.

CONCLUSION:

Herein we describe epidemiologic data of biologic use in PSC-IBD patients at an academic center. PSC-IBD classically follows a less severe clinical presentation and course. However, our study demonstrates that a subset of PSC-IBD patients exist which require biologic therapy and follow a more refractory clinical trajectory. In this subset, TDM showed a high incidence of sub-therapeutic trough levels and anti-drug antibodies, leading to a change in therapy in 85% of TDM instances. Larger studies are recommended to better understand this unique subset of PSC-IBD patients.
P044 A Profile of New Start IBD Patients on Multiple Advanced/Biologic Therapies
Authors: John Eric
Published: December 2021

BACKGROUND:

After analyzing patient chart data from nearly 1,000 recently-initiated biologic/JAK inhibitor inflammatory bowel disease (IBD) patients, it was discovered that 6% are treated with multiple advanced/biologic therapies. This analysis sought to profile those new start patients on a multi-biologic/JAK inhibitor regimen against those treated with a single advanced therapy to determine the type of patient who is typically initiated on more than one advanced/biologic therapy, and why the combination is necessary.

METHODS:

An independent market analytics firm collaborated with US gastroenterologists (n=197) to conduct a retrospective chart review of patients with inflammatory bowel disease (IBD) (n=999) who were started on a biologic agent for the first time. Gastroenterologists submitted patient-level data via a HIPAA-compliant audit form which included both clinical and non-clinical data. The data were collected and analyzed in April-June 2021.

RESULTS:

7% of ulcerative colitis (UC) and 5% of Crohn’s disease (CD) patients are currently treated with more than one biologic/JAK inhibitor. The most common therapy used in combination with another for UC is adalimumab (36%), followed by infliximab brand (18%), and ustekinumab (18%). For CD, the most common combinations involve infliximab brand (35%), followed by vedolizumab (22%), and ustekinumab (13%). The necessity for multiple biologic therapy is clarified when reviewing the IBD patients' comorbidities and medical history. The prevalence of ulcerative proctitis (34% vs. 11%) and gastroduodenal CD (43% vs. 4%) among multi-biologic/JAK inhibitor patients is higher than among those treated with one biologic/JAK inhibitor. Additionally, multi-biologic/JAK inhibitor patients have an increased prevalence of recent bowel perforation (16% vs. 1%) and surgical bowel re-section (10% vs. 3%) compared to those treated with just one advanced therapy. Due to this more severe disease profile, patients treated with more than one advanced/biologic therapy are more likely to report severe impairment in work performance (48% vs. 34%), chronic fatigue comorbidity (23% vs. 5%), more frequent ER visits per year (average= 2.3 vs. 1.1), and more frequent hospitalizations per year (2.0 vs. 0.6).

CONCLUSION:

A profile of new start biologic IBD patients ideal for concomitant advanced therapy emerged when reviewing almost 1,000 physician-reported patient records. These patients are more likely to have had gastroduodenal Crohn’s disease and or recent bowel perforation or re-section. These patients are more likely to report impaired work performance, chronic fatigue, more frequent ER visits and more frequent hospitalizations.
P073 Diagnostic Outcome of Patients With Non-Specific Colitis
Authors: Guzmán-Cárcamo Ana , Navarro Gerrard Christian , Severino Ferreras Indhira , López Goméz Jesús , Cortes Espinosa Tomas , Ramos Gómez Mayra , Paredes Amenabar Carlos , Navarro-Gerrard Megan
Published: December 2021

BACKGROUND:

Colitis describes inflammation in the colon and is classified into defined diseases: Inflammatory bowel disease (IBD), Microscopic colitis, Ischemic colitis and Infectious colitis. The clinical significance of non-specific colitis is unclear as there are limited analysis which report the issue. Notteghem et al. (1993) showed that of 104 patients with non-specific colitis, 52.3% had another episode of symptoms within 3 years. Of these patients 54% were diagnosed with ulcerative colitis, 33% with Crohn's disease, and 13% remained unclassified, suggesting that non-specific colitis could be undiagnosed IBD. The objective of this analysis is to determine the clinical course of non-specific colitis through colonoscopy and histologic findings.

METHODS:

Retrospective observational study with patients underwent colonoscopies during the period from 2009 to 2019, whose biopsies were reported as non-specific colitis.

RESULTS:

24 patients (18 women and 6 men) with non-specific colitis undergoing follow-up by the Gastroenterology outpatient clinic were included. The most frequent indications for colonoscopy were abdominal pain (43.7%), blood in stools (26.8%), diarrhea (21.6%) and anemia (7.9%). The mean age was 56.5 years. During follow-up, patients had at least 2 colonoscopies and 4 biopsies per colonic segment. In the male population ascending colon cancer was later diagnosed in 16.7%, another 16.7% were diagnosed with nonspecific chronic ulcerative colitis, 33.3% with eosinophilic colitis, and the rest of the patients were diagnosed with non-specific colitis. From the female group, 5.6% had lymphocytic colitis, 5.6% eosinophilic colitis, 5.6% collagenous colitis, 5.6% Crohn's disease, 5.6% mixed irritable bowel syndrome, and the rest of the patients (72%) had biopsy report of non-specific colitis.

CONCLUSIONS:

All patients with a histopathological diagnosis of non-specific colitis underwent a second colonoscopy with biopsy, which resulted in a definitive diagnosis of Crohn's disease in 5.6% of women and Ulcerative Colitis in 16.7% of men. This study comes to show that there is an important subgroup of patients who are underdiagnosed. We suggest that patients with non-specific colitis reported on a histopathology report must continue their follow-up by a specialized ward.
El discurso de las proclamas militares de los golpes de Estado en la Argentina: un análisis estratégico
Authors: Menéndez Salvio Martín
Published: December 2021

Nos proponemos analizar estratégicamente una serie discursiva compuesta por las proclamas militares de los golpes de estado que durante el siglo XX en la República Argentina.  La reconstrucción de estos dispositivos estratégicos explica el funcionamiento discursivo y permite justificar la interpretación que se hace de los discursos que forman la serie. La serie está formada por los siguientes discursos: el del 6 de septiembre de 1930 discurso inaugural del discurso de golpe de estado, la proclama del 4 de junio de 1943 hecha por el Grupo de Oficiales Unidos (GOU), el del 16 de septiembre de 1955 (Revolución Libertadora), el del 28 de junio de 1966 (Revolución Argentina) y el del 24 de marzo de 1976 (Proceso de Reorganización Nacional). Analizaremos la estrategia Justificar la ruptura del orden constitucional a partir de tres movimientos centrales que la conforman: i) Ubicación del sujeto discursivo; ii) Uso de la paradoja o contradicción explícita y, iii) Invocación.
De las guías de escritura al macro-género. La relevancia del conocimiento lingüístico en los Programas de Lectura y Escritura.
Authors: Acebal Martin M.
Published: December 2021

El artículo desarrolla la eficacia de las nociones de género elemental y macro-género para la intervención lingüístico-pedagógica sobre guías de escritura producidas en una asignatura universitaria para orientar a las y los estudiantes en la elaboración de textos. El trabajo reflexiona y muestra los resultados de una experiencia realizada en la asignatura “Prácticas Profesionales I” en el marco del Programa de Lectura y Escritura Académica (PROLEA) implementado en Universidad de Flores (Buenos Aires, Argentina). En el PROLEA, la o el especialista del Programa identifica las instancias de escritura de la asignatura y mantiene intercambios con la o el docente disciplinar para conocer sus objetivos y diseñar la intervención del Programa en la asignatura. En ocasiones nos encontramos con guías de escritura producidas por el/la docente disciplinar para la elaboración de los textos. El artículo sostiene y muestra con ejemplos que el abordaje lingüístico-genérico posibilita una relectura de estas guías desarrolladas en la asignatura, a la vez que permite diseñar su incorporación en las intervenciones didácticas del Programa. La capacidad explicativa de la propuesta genérica y los resultados obtenidos demuestran la importancia del especialista en el lenguaje, del andamiaje lingüístico-funcional y de la investigación en los Programas de Lectura y Escritura universitarios.
Estrategias de explicación y argumentación en el discurso de la matemática. Recursos lingüísticos de la oralidad y la escritura empleados para la enseñanza y el aprendizaje en los primeros años de carreras de ingeniería
Authors: Matiolli Estela
Published: December 2021

En este proyecto se recuperarán los resultados que el equipo de trabajo ha alcanzado en experiencias investigativas anteriores, las cuales han abordado las características del discurso de la ciencia en diferentes disciplinas y los modos más productivos de comunicarlo a los estudiantes universitarios para colaborar en su interpretación y reelaboración, promoviendo la construcción de los conocimientos científico-disciplinares específicos. En esta oportunidad se analizarán las estrategias de explicación y argumentación en el discurso de la matemática, y los recursos lingüísticos de la oralidad y la escritura empleados para la enseñanza y el aprendizaje en los primeros años de carreras de ingeniería en el ámbito de la Facultad de Ingeniería y Ciencias Hídricas de la Universidad Nacional del Litoral. Este trabajo interdisciplinario entre docentes de Lengua y Matemática busca describir los modos empleados por expertos y legos para explicar y argumentar, identificando los aspectos que presentan mayor dificultad tanto en el discurso oral como escrito, mediado o no por las TIC, para posteriormente elaborar propuestas de enseñanza a desarrollar dentro de cada asignatura (Comunicación Oral y Escrita y las seis Matemáticas) que favorezcan el desempeño de los estudiantes. El trabajo se enmarcará en la perspectiva que ofrece la Lingüística Sistémico Funcional, además de considerar los aportes del campo de las didácticas específicas y las posibilidades del uso de las nuevas tecnologías de la información y la comunicación (TIC).
Uma entrevista com Lúcia Maria S. V. Costa Ramos
Authors: Ribeiro Jonathan , Ramos Lúcia Maria S. V. Costa
Published: December 2021

»Doutora em Ciência da Informação, Escola de Comunicações e Artes, Universidade de São Paulo.
»Diretora Técnica do Serviço de Documentação Odontológica, Faculdade de Odontologia, Universidade de São Paulo.
»Coordenadora da Rede BVS Odontologia Brasil, Pesquisadora do Núcleo de Pesquisa e Tecnologia em Produção Científica do CNPq.
Análise epidemiológica de fraturas buco-maxilo-faciais em um hospital de referência do Tocantins
Authors: Santos Mariana Araújo dos , Gellen Paula Vitória Bido , Moreira Hyara Luz , Alves Marcos Phelipe Araújo Andrade , Borges Tássia Silvana , Almeida José Afonso de
Published: December 2021

Introdução: Estudos epidemiológicos sobre traumatismos buco-maxilo-faciais desempenham um importante papel em saúde pública, ao direcionar ações de promoção de saúde, prevenção e diagnóstico. Objetivo: O objetivo do presente estudo foi identificar o perfil de pacientes traumatizados, com ênfase em fraturas buco-maxilo-faciais atendidas em um hospital de referência na região Norte do país. Métodos: Foi realizada a análise retrospectiva dos prontuários de pacientes atendidos em um período de sete anos, coletando-se as variáveis sexo, idade, diagnóstico, etiologia e sítio anatômico. Realizou-se uma análise descritiva dos dados e algumas variáveis foram avaliadas pelo teste do qui-quadrado. Resultados: Foram analisados 471 casos, sendo a maioria do sexo masculino (73,5%; n=346) e da faixa etária entre 20 e 35 anos (48,6%; n=229). No que tange aos fatores etiológicos, 56,5% (n=266) dos pacientes foram vítimas de acidentes de circulação, sendo a etiologia mais prevalente. Já as agressões físicas corresponderam a 24,8% (n=117) dos casos atendidos. Com base nisso, a localização buco-maxilo-facial mais atingida foi o osso mandibular (n=121; 25,7%), seguido do osso nasal e complexo zigomático. Conclusão: O perfil epidemiológico de trauma no hospital estudado consistiu de homens com 20 a 35 anos de idade, envolvidos principalmente em acidentes de circulação, que tiveram trauma de face isolado, com fratura do osso mandibular.
Uso de smartphones para estudo e desenvolvimento profissional por cirurgiões e residentes em Cirurgia Buco-Maxilo-Facial
Authors: Vilaça Luiz Felipe Rocha , Araujo Lourrany Carmo , Brito Lucas Teixeira , Pereira Gustavo Campolina Barbosa , Garcia Robson Rodrigues , Goulart Douglas Rangel
Published: December 2021

Objetivo: O objetivo do presente estudo foi avaliar a prevalência do uso de smartphones com finalidade de desenvolvimento profissional em Cirurgia Buco-Maxilo-Facial. Métodos: Foi realizado um estudo transversal com residentes e cirurgiões especialistas em Cirurgia e Traumatologia Buco-Maxilo-Facial (CTBMF) no período de julho de 2020 a fevereiro de 2021. Os dados foram coletados por meio de um formulário eletrônico elaborado especificamente para esse estudo e disponibilizado por meio de link e enviado por e-mail. Resultados: Foram incluídos no estudo 83 participantes; dos quais 65,1% eram especialistas em CTBMF, enquanto 34,9% eram residentes. Entre os residentes, a maior participação foi entre aqueles do primeiro e terceiro anos, com 51,7% e 34,5%, respectivamente. Desses profissionais, 80,7% relataram utilizar algum aplicativo no smartphone com finalidade de educação continuada na área de CTBMF. O aplicativo mais utilizado com essa finalidade foi o AO Manual Surgery, com a taxa de uso de 15,6% entre os especialistas e residentes. Além disso, do total de participantes, 78,3% afirmaram que seguem perfis nas redes sociais com finalidade de desenvolvimento profissional e/ou educacional. A mídia social mais utilizada foi o Instagram, com 50,7% dos usuários. Conclusão: Os smartphones podem oferecer um método promissor de entrega e melhoria de acesso às informações de educação para os cirurgiões buco-maxilo-faciais. Para isso, no entanto, é necessária a criação de novos aplicativos e um controle de qualidade das informações fornecidas.
Hunger in Zeiten von Ungleichheit, Klimawandel und Pandemie
Authors: Jahn Johannes
Published: December 2021

Als Folge von Ungleichheit und Armut leiden weltweit Hunderte Millionen Menschen Hunger. Die aktuelle Pandemie und der Klimawandel verschärfen dieses Problem zusätzlich. Welche Gegenmaßnahmen kommen infrage, um diese Entwicklungen zu reduzieren?
Modelo predictivo de insatisfacción con la imagen corporal
Authors: Villegas-Moreno Martha Juliana , Londoño-Pérez Constanza
Published: December 2021

La insatisfacción con la imagen corporal origina y mantiene diversos trastornos, entre
los que se encuentran: problemas de conducta alimentaria, depresión, ansiedad,
y desorden dismórfico corporal y muscular. Esta ha sido comprendida desde teorías
socioculturales que explican la internalización de actuales estereotipos de belleza
imperantes en la sociedad occidental a partir de presión ejercida por medios de comunicación,
grupo de pares y familia. El objetivo de este estudio fue identificar las
variables individuales, sociales y culturales que en interacción predicen la insatisfacción
con la imagen corporal. La muestra estuvo conformada por 270 participantes,
hombres y mujeres con edades entre 13 y 57 años, con distintas características sociodemográficas.
Se usaron cinco cuestionarios para evaluar las variables de asociación
y de desenlace. Se encuentran correlaciones positivas y significativas de variables,
como preocupación por la comida, ideal de delgadez y bulimia, y la insatisfacción
corporal. El modelo predictivo de la insatisfacción con la imagen corporal con el
mejor nivel ajuste, principalmente incluye variables relacionadas con la salud mental,
actitudes socioculturales y características demográficas. Se concluye que actitudes
favorables en torno al ideal de belleza y la presencia de trastornos de salud mental
específicos predicen la insatisfacción con la imagen corporal.
“Visualidade” educacional na Guiné-Bissau à luz da teoria de banda desenhada, ou seja, uma revisão trans/pós-colonial das ideias didáticas/pedagógicas no âmbito da lusofonia
Authors: Jankowski Jakub , Stańczyk Piotr
Published: December 2021

The main purpose of the article is to present analysis of comic book Nô Pintcha which – as we state – is the exceptional example of visual representation of theory of education from period of early independence of former portuguese colonies in Africa. Nô Pintcha was published in 1978 during the summit of ministers of education and educators from Angola, Cape Verde, Guinea Bissau, Mozambique and São Tomé. Authors of Nô Pintcha considered comic book as a apendix to the basic literacy campaign in Guinea Bissau. Theory of education which was used during literacy campaign had origins of emancipatory popular education of Paulo Freire. Thus the analysis presented in this paper lies parallely in looking for the Nô Pintcha in perspective of comic book theory as well in looking for traces Freire’s theory.
Healthy lungs maintain a young and energetic body
Authors: Petrescu Florian Ion Tiberiu , Petrescu Relly Victoria Virgil
Published: December 2021

In general, life is only possible in the presence of oxygen in a form that can be easily absorbed by the body. In the case of humans, the lungs have as their main task the provision of the oxygen necessary for the body to carry out daily activities. The lung is a paired organ located in the chest cavity, a fibro-elastic organ capable of altering your volume during breathing (inspire and expire). The weight of a lung varies between 800 and 1,000 grams, of which more than 50% is blood. The air reaches the lungs through a pipeline system consisting of Nazo-pharynx, larynx, trachea, bronchi, and bronchiole. The role of the piping system is to heat and dampen the air or to capture and remove foreign inhaled particles. The channel system decreases in diameter after each branch - from the trachea and the large bronchi to the bronchiole with a diameter of less than one millimeter. The lung consists of over 30 different cell types. Trachea and large bronchi are taped by a mucous layer containing multiple cell types: ciliary cells - provides mucus movement, caliciform cells - secretes mucus, basal cells - plays a role in regeneration and neuro-ectodermic cells - ensures the secretory function of the lungs. In the chorion (the deep layer beneath the mucosa) there are cells involved in the defense processes - lymphocytes, mast cells, eosinophils or neutrophils.
About biological hip joint prostheses and the biomechanical behavior of implanted femur
Authors: Aversa Raffaella , Petrescu Relly Victoria Virgil , Apicella Antonio , Petrescu Florian Ion Tiberiu
Published: December 2021

Biofidel femur Models with finite elements were developed using a specific segmentation combination with computed tomography and solid modeling tools capable of representing bone physiology and structural behavior. These biofidel Finite Element Models (FEM) are used to evaluate the change in the physiological distribution of stress in the prosthesis femur and to evaluate the new design criteria for biopsy biopsy biopsy biopsy. The proposed belief patterns allowed us to adequately take into account the non-isotropic features of the proximal femoral epiphysis and isotropic behavior in diaphysis to explain the critical changes in stress distribution in a femur resected after the implantation of a traditional articular prosthesis. It has been shown that a wide range of femoral diaphyses is completely protected by rigid prostheses that significantly alter the physiological distribution of stress, which should guarantee healthy growth and bone regeneration.
Restriction for general linear groups: The local non-tempered Gan–Gross–Prasad conjecture (non-Archimedean case)
Authors: Chan Kei Yuen
Published: December 2021

We prove a local Gan–Gross–Prasad conjecture on predicting the branching law for the non-tempered representations of general linear groups in the case of non-Archimedean fields. We also generalize to Bessel and Fourier–Jacobi models and study a possible generalization to Ext-branching laws.
Finanzwende und Zivilgesellschaft
Authors: Hülsdünker Timo , Hoffart Franziska M.
Published: December 2021

Obwohl ein breiter wissenschaftlicher Konsens bezüglich des anthropogenen Klimawandels besteht und seine Folgen immer stärker erforscht und spürbar sind, verschärft sich die Klima- und Biodiversitätskrise zusehends. In diesem Artikel erläutern wir, wieso es ein neues Wirtschaftsnarrativ für die Bekämpfung der Klima- und Biodiversitätskrise braucht, was eine Finanzwende zur Folge hat und warum diese nur gesamtgesellschaftlich gelingen kann. Zudem diskutieren wir die Grundlage und Herausforderungen, die durch die nachhaltige Transformation für Unternehmen entstehen, und geben konkrete Impulse für 1,5-Grad-kompatible Finanzinstitute. Es wird deutlich, dass Finanzinstitute eine zentrale Rolle in der sozial-ökologischen Transformation zu einer lebenswerten 1,5-Grad-kompatiblen Zukunft spielen und Geld als gesellschaftliches Gestaltungsmittel eine positive Wirkung entfalten kann, wenn es zweck- und nicht zielorientiert eingesetzt wird.
Whistleblowing im Finanzsektor: eine Zwischenbilanz mit Ausblick
Authors: Oelrich Sebastian
Published: December 2021

Dieser Artikel thematisiert Whistleblowing als ein wichtiges Instrument einer transparenten und fairen Finanzwirtschaft. Dabei werden bereits bestehende Mechanismen und Regelungen zum internen und externen Whistleblowing in Deutschland insbesondere im Finanzsektor hervorgehoben und mit anderen Bereichen und Ländern verglichen. Es werden zudem Limitationen und Best Practices sowie die Auswirkung der aktuellen europäischen Richtlinie zum Hinweisgeberschutz diskutiert. Die Arbeit schließt mit einem Ausblick sowie Forderungen zur Ausweitung und Ergänzung bestehender Whistleblowing-Regelungen, durch die der Finanzplatz Deutschland gestärkt werden kann.
Effect of Auraptene on angiogenesis in Xenograft model of breast cancer
Authors: Shiran Mohammad Reza , Mahmoudian Elham , Ajami Abolghasem , Hosseini Seyed Mostafa , Khojasteh Ayjamal , Rashidi Mohsen , Maroufi Nazila Fathi
Published: December 2021

Objectives

Angiogenesis is the most important challenge in breast cancer treatment. Recently, scientists become interesting in rare natural products and intensive researches was performed to identify their pharmacological profile. Auraptene shows helpful effects such as cancer chemo-preventive, anti-inflammatory, anti-oxidant, immuno-modulatory. In this regard, we investigated the anti-angiogenesis effect of Auraptene in in-vitro and in-vivo model of breast cancer.

Methods

In this study, 4T, MDA-MB-231 and HUVEC cell lines were used. The proliferation study was done by MTT assay. For tube formation assay, 250 matrigel, 1 × 104 HUVEC treated with Auraptene, 20 ng/mL EGF, 20 ng/mL bFGF and 20 ng/mL VEGF were used. Gene expression of important gene related to angiogenesis in animal model of breast cancer was investigated by Real-time PCR. Protein expression of VCAM-1 and TNFR-1 gene related to angiogenesis in animal model of breast cancer was investigated by western-blot.

Results

Auraptene treatment led to reduction in cell viability of MDA-MB-231 in a concentration-dependent manner. Also, we observed change in the number of tubes or branches formed by cells incubated with 40 and 80 μM Auraptene. Auraptene effect the gene expression of important gene related to angiogenesis (VEGF, VEGFR2, COX2, IFNɣ). Moreover, the western blot data exhibited that Auraptene effect the protein expression of VCAM-1 and TNFR-1.

Conclusions

Overall, this study shows that Auraptene significantly suppressed angiogenesis via down-regulation of VEGF, VEGFR2, VCAM-1, TNFR-1, COX-2 and up-regulation of IFNγ.
Gender Trouble and Return of theSexualin a Cisgender Research Collective Confronted With Trans∗ Femininity
Authors: Molinier Pascale
Published: December 2021

The author analyzes a research study of trans∗ women and their surgeons, conducted before and after vaginoplasty in a French public hospital service. The essay is an examination of countertransference in three research frameworks: (1) working with a research team; (2) taking part in a peer group, facilitated by a psychologist, a surgeon, and a secretary, bringing together women who had already undergone surgery and those awaiting it; and (3) research interviews with Lara, a 64-year-old trans∗ woman. The author emphasizes the importance of taking into account gender countertransference—that is, the disruptive effects of the encounter with trans∗ people and their desires, paying specific attention to what the encounter with trans∗ femininities has stirred or revealed in terms of the author's own relationship to the body and to cisgender femininity.
Countertransference Madness: Supervision, Trans∗, and the Sexual
Authors: Evzonas Nicolas
Published: December 2021

Drawing on Ferenczi's “confusion of tongues” paradigm, the author argues that the internalization of the supervisor's superego has the potential not only to expand the supervisee's ego (introjection), but also to repress their idiosyncratic functions and attack their thinking activity (intropression). To illustrate this argument, the author recounts his own supervised treatment of a transgender patient during which the supervisor-supervisee transference lapsed into a sadomasochistic dialectic and a folie à deux, leading to the premature termination of both the therapy and the supervision. While the initial interpretation of this experience underscored the supervisor's transphobia, the après-coup of writing up the case has revealed more complex thinking. Accordingly, the countertransference madness to which the author succumbed with his supervisor can now be understood as the unbinding of repressed infantile sexuality and the reenactment of paradoxical scenarios that the patient experienced with his parents.
Morphological Evaluation of Mitral Valve Based on Three-dimensional Printing Models: Potential Implication for Mitral Valve Repair
Authors: Yang Yuanting , Wang Hao , Song Hongning , Hu Yugang , Gong Qincheng , Xiong Ye , Liu Junbi , Ren Wei , Zhou Qing
Published: December 2021

Objective: This study aimed to analyze the morphological characteristics of rheumatic (RMVD) and degenerative mitral valve diseases (DMVD) based on three-dimensional (3D) printing model before and after surgery and to explore the potential implication of the 3D printing model for mitral valve (MV) repair.

Methods: 3D transesophageal echocardiography (TEE) data of the MV were acquired in 45 subjects (15 with RMVD, 15 with DMVD, and 15 with normal MV anatomy). 3D printing models of the MV were constructed by creating molds to be printed with water-soluble polyvinyl alcohol, then filled with room temperature vulcanizing silicone. The parameters of the annulus and leaflet of the MV were acquired and analyzed using the 3D printing model. Mitral valve repair was simulated on 3D printing models of 10 subjects and compared with the actual operation performed on patients. The effects of surgery were assessed by evaluating the changes in coaptation length (CL) and the annular height to commissural width ratio (AHCWR) before and after MV repairs. The correlations of the grade of mitral regurgitation with CL and AHCWR were analyzed.

Results: 3D silicone MV models were all successfully constructed based on 3D TEE data. Compared with the normal groups, the mitral annulus size in the RMVD groups showed no significant differences. In contrast, mitral annulus in DMVD groups was dilated and flattened with diameters of anteroposterior, anterolateral-posteromedial, commissural width, annular circumferences, and area increased. Mitral repair was successfully simulated on 10 models with significant increase in leaflet coaptation area both in vivo and in vitro. Good agreement was observed in CL and AHCWR after surgery in the 3D printing model compared with real surgery on the patient valve. The grade of mitral regurgitation correlated inversely with CL (r = –0.87, P < 0.01) and AHCWR (r = –0.79, P < 0.01). Mitral valve repair was performed twice in one model to assess which provided a better outcome.

Conclusions: 3D printing models of the MV based on 3D TEE data could be used in morphological analysis of the MV before and after surgery in RMVD and DMVD. Surgery simulation on 3D printing models could provide valuable information concerning morphological changes after surgery, with are closely associated with clinical outcomes.
Words May Jump-Start Meaning More Than Vision: A Non-Replication of Early ERP Effects in Boutonnet and Lupyan (2015)
Authors: de Leeuw Joshua R. , Andrews Jan , Barney Lori , Bigler Margaret , Bruna Polyphony J. , Chen Yijing , Cherry Ryan , Dowie Davon R. , Forbes Eden , Haffey Ben , Hu Xinyue , Jaklitsch Michael , Leopold Nicole , Lewis Caitlin , MacDonald Dylan , McShaffrey Connor , Monroy-Spangenberg Erik , Nakayama Karen , Olstad Wesley , Peng Rebecca , Scott-Rifer Griffin , Wan Allison , Willans Logan , Zhang Lingxiu
Published: December 2021

We report a replication of Boutonnet and Lupyan’s (2015) study of the effects of linguistic labelling on perceptual performance. In addition to a response time advantage of linguistic labels over non-linguistic auditory cues in judging visual objects, Boutonnet and Lupyan found that the two types of cues produced different patterns in the early perceptual ERP components P1 and P2 but not the later, semantics-relevant N4. This study thus adds an important piece of evidence supporting the claim of genuine top-down effects on perception. Given the controversy over this claim and the need for replication of key findings, we attempted to replicate Boutonnet and Lupyan (2015). We replicated their behavioral findings that response times to indicate whether an auditory cue matches a visual image of an object were faster for match than mismatch trials and faster for linguistic than non-linguistic cues. We did not replicate the main ERP effects supporting a positive effect of linguistic labels on the early perceptual ERP components P1 and P2, though we did find a congruence by cue type interaction effect on those components. Unlike Boutonnet and Lupyan, we found a main effect of cue type on the N4 in which non-linguistic cues produced more negative amplitudes. Exploratory analyses of the unpredicted N4 effect suggest that the response time advantage of linguistic labels occurred during semantic rather than early visual processing. This experiment was pre-registered at https://osf.io/cq8g4/ and conducted as part of an undergraduate cognitive science research methods class at Vassar College.
Landfast sea ice in the Bothnian Bay (Baltic Sea) as a temporary storage compartment for greenhouse gases
Authors: Geilfus N.-X. , Munson K. M. , Eronen-Rasimus E. , Kaartokallio H. , Lemes M. , Wang F. , Rysgaard S. , Delille B.
Published: December 2021

Although studies of biogeochemical processes in polar sea ice have been increasing, similar research on relatively warm low-salinity sea ice remains sparse. In this study, we investigated biogeochemical properties of the landfast sea ice cover in the brackish Bothnian Bay (Northern Baltic Sea) and the possible role of this sea ice in mediating the exchange of greenhouse gases, including carbon dioxide (CO2), methane (CH4), and nitrous oxide (N2O) across the water column–sea ice–atmosphere interface. Observations of total alkalinity and dissolved inorganic carbon in both landfast sea ice and the water column suggest that the carbonate system is mainly driven by salinity. While high CH4 and N2O concentrations were observed in both the water column (up to 14.3 and 17.5 nmol L–1, respectively) and the sea ice (up to 143.6 and 22.4 nmol L–1, respectively), these gases appear to be enriched in sea ice compared to the water column. This enrichment may be attributable to the sea ice formation process, which concentrates impurities within brine. As sea ice temperature and brine volume decrease, gas solubility decreases as well, promoting the formation of bubbles. Gas bubbles originating from underlying sediments may also be incorporated within the ice cover and contribute to the enrichment in sea ice. The fate of these greenhouse gases within the ice merits further research, as storage in this low-salinity seasonal sea ice is temporary.
METHODOLOGY AND METHODOLOGICAL APPROACHES TO STRUCTURING THE ORGANIZATIONAL AND ECONOMIC MECHANISM OF INNOVATIONORIENTED PUBLIC-PRIVATE PARTNERSHIP
Authors:   Odessa National Polytechnic University, Malin Oleksandr
Published: December 2021

The organizational and economic mechanism of innovationoriented public-private partnership should have a scientifically sound structure and a clear clearly structured conceptual model that can provide a superstructure for the regulation of its activities and development. It is provided by structuring and modeling of the organizational and economic mechanism is in accordance with the defined goals and innovation. That is, the structuring of the organizational and economic mechanism of innovation-oriented publicprivate partnership has a model completion and should have instrumental and functional support. The structuring of the organizational and economic mechanism of innovation-oriented public-private partnership in accordance with the defined goals, innovative technological solutions, created innovative value and other features reflects several of its variable models, which differ in format, but provide a holistic view of the mechanism. That is, the structuring of the organizational and economic mechanism of innovation-oriented public-private partnership has a model completion and should have instrumental and functional support.
THEORETICAL BASIS OF CAPITALIZATION MANAGEMENT OF THE ENTERPRISE
Authors:   Kyiv National University of Trade and Economics, Dyeyeva Nataliya , Ziniuk Mykola ,   Kyiv National University of Trade and Economics
Published: December 2021

Even today we can predict that the main consequence of the new technological wave will be that the cost of labor will cease to be decisive in the formation of production costs. This means that the low-skilled labor force that makes up developing countries and some sectors of the Ukrainian economy will cease to be significant. And the main factor will be the technological potential. Ukrainian higher education institutions also see great prospects in the further development of digitalization. Digital business transformation is a smarter result. The combination of digital technologies with the organizational and human changes needed to build a digital information-oriented culture allows organizations, including corporate entities, to significantly increase business efficiency
STUDY OF THE ITALIAN ADMINISTRATIVE SYSTEM
Authors:   Odessa National Polytechnic University, Syta Yevgeniia , Babska Ilona ,   Odessa National Polytechnic University
Published: December 2021

The article considers the peculiarities of the organization of judicial power in Italy. Considerable attention is paid to the concept of administrative justice according to foreign legal doctrine. The legal basis of the activities of administrative justice bodies in Italy was analyzed, the structure of administrative justice bodies and their main powers were revealed. The conclusion defines the place of administrative justice bodies in the Italian judicial system.
THEORETICAL BASIS OF CAPITALIZATION MANAGEMENT OF THE ENTERPRISE
Authors:   Institute of Market Problems and Economic&Ecological Research, National Academy of Sciences of UkraineInstitute of Market Problems and Economic&Ecological Research, National Academy of Sciences of Ukraine, Khumarova, Nina , Laiko Oleksandr ,   Institute of Market Problems and Economic&Ecological Research, National Academy of Sciences of Ukraine
Published: December 2021

Due to inefficient capital management at the level of enterprises, regions and the country as a whole, Ukraine's economy faces significant problems, which are exacerbated by the crisis in the world economy and the COVID-19 pandemic. Therefore, the search for new and improvement of existing approaches and methods of capital management of enterprises is relevant. In the context of enterprise capital management on the basis of regulatory models, a modification of the "golden rule" is proposed by taking into account the growth rate of enterprise value The structure of the general system of capitalization management of the country's economy is determined, which provides for the coordination of individual enterprises and determination of strategic goals of capitalization of the country's economy, taking into account the norms of morality, traditions and values professed by society. The understanding of the essence of real and fictitious capitalization of the enterprise is specified. It is shown that there is a connection between them, but its description is qualitative.
Utjecaj usluga zračnog prijevoza na razinu lojalnosti turističkih putnika
Authors: Dedić Samira , Mujić Ermin , Puška Adis
Published: December 2021

Opći cilj istraživanja je utvrditi intenzitet i smjer povezanosti zračnog prijevoza i razine lojalnosti turističkih putnika. U radu su testirane i detaljno analizirane tri radne hipoteze istraživanja. Empirijsko istraživanje provedeno je na temelju prikupljenih primarnih podataka terenskim istraživanjem, pri čemu je primijenjen visoko strukturirani anketni upitnik kao obrazac za prikupljanje podataka. U anketnom upitniku korištena je Likertova skala s pet stupnjeva slaganja. Ispitanici su korisnici usluga zračnog prijevoza u Bosni i Hercegovini. Istraživanje je provedeno na dva međunarodna aerodroma Sarajevo i Tuzla, a obuhvaćene su četiri niskotarifne zrakoplovne kompanije Wizz Air, Pegasus Airlines, Germanwings i Norwegian Air Shuttle. Kako bi se odgovorilo na postavljena istraživačka pitanja vezana za ispitivanje intenziteta i smjera utjecaja zračnog prijevoza na razinu lojalnosti turističkih putnika, primijenjeni su različiti postupci i metode obrade podataka u skladu s postavljenim istraživačkim problemima.
How Sociology Perspective Influence Law with a Social Contexts? A Book Review “Pokok-Pokok Sosiologi Hukum”, Prof Dr Soerjono Soekanto SH MA, Rajawali Pers, 269 Pages, ISBN 979-421-131-1
Authors: Abraham Abraham
Published: December 2021

sociology of law examines why humans obey the law and why it fails to obey the law and the social factors that influence it. as a relatively new branch of sociology, the science of legal sociology was developed to explain the interrelationships of patterns of behavior and law that cannot yet be explained by other branches of social science.
Capital Punishment for Drug Abuse Crime: Legal Limitations and Requirements
Authors: Bayu Faryzuhud
Published: December 2021

I write this paper about the death penalty for narcotics dealers, many countries still apply the death penalty like one of them is Indonesia, although many criticize the execution of capital punishment for drug dealers, but the death penalty is still done in Indonesia, because it is believed to be the most appropriate step for the drug dealers who have damaged this generation of Indonesian nation, and in this paper I justify or approve if the drug dealer is sentenced to death because the drugs damage the young generation and damage the nation's morale.