bluuebunny/crossref_metadata_2025 huggingface dataset:
Reflection of Acoustic Wave through Multilayered Porous Sea Ice Sandwiched between the Water and Air Half-Spaces
Authors: Li Shande , Liu Shaowei , Yuan Shuai , Wen Jian , Zhang Zhifu
Published: August 2021

To establish an accurate sea ice model is a tremendous challenge in Arctic acoustic research. Regarding this matter, a multilayered porous sea ice model is proposed based on Biot’s theory in this paper. Assuming that the model is sandwiched between the water and air half-spaces, the reflection coefficient of an incident wave from water into ice is deduced and contrasted with the solution calculated by impedance transfer method (ITM) to demonstrate the verification of the model. Furthermore, the influences of frequency, porosity and layering on reflection coefficients are analyzed. The results reveal that the reflection coefficient is closely associated with layering and porosity. Therefore, it is reasonable and necessary to simultaneously take the layering and porosity of ice into consideration. Different from the existing layered or porous ice model, the presented model synthesizes the layered characteristic and porous structure of ice, which better portrays the real condition of sea ice. It is an improvement of the broadly used stratified or porous sea ice model, which provides ideas for further sea ice modeling.
Development of Wireless and Passive SAW Temperature Sensor with Very High Accuracy
Authors: Gao Xu , Cheng Lina , Xue Xufeng , Zhai Shoupei , Liang Yong , Wang Wen , Liu Mengwei , Zhu Jialiang , Li Zhuoyue
Published: August 2021

A surface acoustic wave (SAW) temperature sensor with high accuracy was developed and wirelessly characterized in this work. The sensing chip with reflective delay line pattern was simulated using typical coupling of modes (COM) model and prepared by the standard photolithographic technique. Sharp reflection peaks with high signal-to-noise (SNR) were observed from the developed sensing chip operating at 433 MHz. Referring to the frequency-stepped continuous wave (FSCW)-based transceiver, planar antennas, and the developed SAW chip, the wireless and passive temperature sensor system was built. Adaptive Least Mean Square (LMS) algorithm was used for the first time in the SAW sensor signal processing to significantly improve the system SNR, and the corresponding phase fluctuation is down to only 3°. High temperature sensitivity of 36.5 °C and very high accuracy of ±0.2 °C in the range of −30 °C∼100 °C were achieved successfully by wireless measurement.
Research on Multicore Key-Value Storage System for Domain Name Storage
Authors: Han Luchao , Guo Zhichuan , Zeng Xuewen
Published: August 2021

This article proposes a domain name caching method for the multicore network-traffic capture system, which significantly improves insert latency, throughput and hit rate. The caching method is composed of caching replacement algorithm, cache set method. The method is easy to implement, low in deployment cost, and suitable for various multicore caching systems. Moreover, it can reduce the use of locks by changing data structures and algorithms. Experimental results show that compared with other caching system, our proposed method reaches the highest throughput under multiple cores, which indicates that the cache method we proposed is best suited for domain name caching.
Full Explicit Numerical Modeling in Time-Domain for Nonlinear Electromagnetics Simulations in Ultrafast Laser Nanostructuring
Authors: Moreno Enrique , Nguyen Huu Dat , Stoian Razvan , Colombier Jean-Philippe
Published: August 2021

The purpose of this paper is to present a new and accurate, fully explicit finite-difference time-domain method for modeling nonlinear electromagnetics. The approach relies on a stable algorithm based on a general vector auxiliary differential equation in order to solve the curl Maxwell’s equation in a frequency-dependent and nonlinear medium. The energy conservation and stability of the presented scheme are theoretically proved. The algorithms presented here can accurately describe laser pulse interaction with metals and nonlinear dielectric media interfaces where Kerr and Raman effects, as well as multiphoton ionization and metal dispersion, occur simultaneously. The approach is finally illustrated by simulating the nonlinear propagation of an ultrafast laser pulse through a dielectric medium transiently turning to inhomogeneous metal-like states by local free-electron plasma formation. This free carrier generation can also be localized in the dielectric region surrounding nanovoids and embedded metallic nanoparticles, and may trigger collective effects depending on the distance between them. The proposed numerical approach can also be applied to deal with full-wave electromagnetic simulations of optical guided systems where nonlinear effects play an important role and cannot be neglected.
Connexin 43 and Sonic Hedgehog Pathway Interplay in Glioblastoma Cell Proliferation and Migration
Authors: Torrisi Filippo , Alberghina Cristiana , Lo Furno Debora , Zappalà Agata , Valable Samuel , Li Volti Giovanni , Tibullo Daniele , Vicario Nunzio , Parenti Rosalba
Published: August 2021

Glioblastoma (GBM) represents the most common primary brain tumor within the adult population. Current therapeutic options are still limited by high rate of recurrences and signalling axes that promote GBM aggressiveness. The contribution of gap junctions (GJs) to tumor growth and progression has been proven by experimental evidence. Concomitantly, tumor microenvironment has received increasing interest as a critical process in dysregulation and homeostatic escape, finding a close link between molecular mechanisms involved in connexin 43 (CX43)-based intercellular communication and tumorigenesis. Moreover, evidence has come to suggest a crucial role of sonic hedgehog (SHH) signalling pathway in GBM proliferation, cell fate and differentiation. Herein, we used two human GBM cell lines, modulating SHH signalling and CX43-based intercellular communication in in vitro models using proliferation and migration assays. Our evidence suggests that modulation of the SHH effector smoothened (SMO), by using a known agonist (i.e., purmorphamine) and a known antagonist (i.e., cyclopamine), affects the CX43 expression levels and therefore the related functions. Moreover, SMO activation also increased cell proliferation and migration. Importantly, inhibition of CX43 channels was able to prevent SMO-induced effects. SHH pathway and CX43 interplay acts inducing tumorigenic program and supporting cell migration, likely representing druggable targets to develop new therapeutic strategies for GBM.
The Role of Immune-Related miRNAs in the Pathology of Kidney Transplantation
Authors: Boštjančič Emanuela , Večerić-Haler Željka , Kojc Nika
Published: August 2021

MicroRNAs (miRNAs) are members of the non-coding regulatory RNA family that play pivotal roles in physiological and pathological conditions, including immune response. They are particularly interesting as promising therapeutic targets, prognostic and diagnostic markers due to their easy detection in body fluids and stability. There is accumulating evidence that different miRNAs provide disease-specific signatures in liquid samples of distinct kidney injuries. Using experimental models and human samples, there have been numerous suggestions that immune-related miRNAs are also important contributors to the development of different kidney diseases as well as important markers for monitoring response after kidney transplantation. However, there are limited data for understanding their function in the molecular pathways of allograft pathologies. In our review, we focused on microRNAs that are related to different aspects of immune response after kidney transplantation.
LightSpot®-FL-1 Fluorescent Probe: An Innovative Tool for Cancer Drug Resistance Analysis by Direct Detection and Quantification of the P-glycoprotein (P-gp) on Monolayer Culture and Spheroid Triple Negative Breast Cancer Models
Authors: Goisnard Antoine , Daumar Pierre , Dubois Clémence , Aubel Corinne , Roux Manon , Depresle Marie , Gauthier Jean , Vidalinc Bernard , Penault-Llorca Frédérique , Mounetou Emmanuelle , Bamdad Mahchid
Published: August 2021

P-gp is the most widely studied MDR protein conferring cellular resistance to many standard or targeted therapeutic agents. For this reason, P-gp chemoresistance evaluation, established before or during chemotherapy, can be very relevant in order to optimize the efficacy of treatments, particularly for aggressive tumoral subtypes such as triple-negative breast cancer (TNBC). In this context, our team developed an innovative cell-permeant fluorescent probe called the LightSpot®-FL-1, which is able to specifically localize and quantify the P-gp in cells or cell masses, as evidenced on different TNBC cell models. First, flow cytometry analysis showed LightSpot®-FL-1 cell penetration and persistence in time, in TNBC cells. Then, LightSpot®-FL-1 staining was compared to anti-P-gp immunostaining by fluorescence microscopy on five TNBC cell lines. Results showed a clear similarity of P-gp localization and expression level, confirmed by Pearson’s and Mander’s colocalization coefficients with 92.1% and 100.0%, and a strong correlation coefficient of R2 = 0.99. In addition, the LightSpot®-FL-1 staining allowed the quantification of a P-gp induction (33% expression increase) following a 6-hour spheroid model exposure to the anti-PARP Olaparib. Thus, the new LightSpot®-FL-1 cell-permeant probe, targeting P-gp, appears to be an effective tool for drug resistance evaluation in preclinical models and shows promising possibilities for future use in clinical diagnosis.
Laryngeal Neural Monitoring during Pediatric Thyroid Cancer Surgery—Is Transcartilage Recording a Preferable Method?
Authors: Huang Tzu-Yen , Kim Hoon-Yub , Dionigi Gianlorenzo , Lu I-Cheng , Chang Pi-Ying , Chiang Feng-Yu , Lin Yi-Chu , Tseng Hsin-Yi , Liu Cheng-Hsin , Wu Che-Wei
Published: August 2021

The use of transcartilage (TC) intraoperative neuromonitoring (IONM) in a pediatric population has not been reported. This study evaluated the feasibility and the benefit of using TC-IONM for thyroid cancer surgery in a pediatric population. This retrospective single-center study enrolled 33 pediatric patients who had received an IONM-assisted thyroidectomy. Demographic characteristics, standardized IONM laryngeal examinations and stimulation information (L1-V1-R1-R2-V2-L2) were compared between endotracheal tube (ET) and TC methods. In the 15 cancer patients (30 nerves), TC-IONM provided significant higher electromyography (EMG) amplitude (p < 0.001), signal stability (lower V1/V2 signal correlation, r = 0.955 vs. r = 0.484, p = 0.004), signal quality (higher ratio of V1 or V2 amplitude <500 µV, 0.0% vs. 43.8%, p = 0.005) and lower R1-R2p change (7.1% vs. 37.5%, p = 0.049) compared to ET-IONM. In the 18 benign patients (28 nerves), TC-IONM provided significantly higher EMG amplitude (p < 0.001), signal stability (r = 0.945 vs. r = 0.746, p = 0.0324) and non-significant higher signal quality and R1-R2p change. This report is the first to discuss the use of TC-IONM in pediatric thyroid surgery. In contrast with ET-IONM, TC-IONM had superior amplitude, stability and quality of EMG signals, which greatly facilitates the meticulous recurrent laryngeal nerve dissection in pediatric thyroidectomies. The TC-IONM method can be considered a feasible, effective and preferable method of monitored thyroidectomy in pediatric thyroid cancer.
Role of Chemotherapy in Vulvar Cancers: Time to Rethink Standard of Care?
Authors: Mazzotta Marco , Pizzuti Laura , Krasniqi Eriseld , Di Lisa Francesca Sofia , Cappuzzo Federico , Landi Lorenza , Sergi Domenico , Pelle Fabio , Cappelli Sonia , Botti Claudio , Vizza Enrico , Tomao Silverio , Marchetti Luca , Sanguineti Giuseppe , Botticelli Andrea , Marchetti Paolo , Magri Valentina , Pisegna Simona , Venuti Aldo , Tomao Federica , Buzzacchino Federica , Ciliberto Gennaro , Barba Maddalena , Vici Patrizia
Published: August 2021

The actual role of chemotherapy in vulvar cancer is undeniably a niche topic. The low incidence of the disease limits the feasibility of randomized trials. Decision making is thus oriented by clinical and pathological features, whose relevance is generally weighted against evidence from observational studies and clinical practice. The therapeutic management of vulvar cancer is increasingly codified and refined at an individual patient level. It is of note that the attitude towards evidence sharing and discussion within a multidisciplinary frame is progressively consolidating. Viable options included in the therapeutic armamentarium available for vulvar cancer patients are frequently an adaption from standards used for cervical or anal carcinoma. Chemotherapy is more frequently combined with radiotherapy as neo-/adjuvant or definitive treatment. Drugs commonly used are platinum derivative, 5-fluorouracil and mitomicin C, mostly in combination with radiotherapy for radiosensitization. Exclusive chemotherapy in the neo-/adjuvant setting comprises platinum-derivative, combined with bleomicin and methotrexate, 5-fluorouracil, ifosfamide or taxanes. In advanced disease, current regimens include cisplatin-based chemoradiation, with or without 5-fluorouracil, or doublets with platinum in combination with a taxane. Our work is also enriched by a concise excursus on the biologic pathways underlying vulvar cancer. Introductory hints are also provided on targeted agents, a rapidly evolving research field.
The Prevalence of Hypogonadism and the Effectiveness of Androgen Administration on Body Composition in HIV-Infected Men: A Meta-Analysis
Authors: Santi Daniele , Spaggiari Giorgia , Vena Walter , Pizzocaro Alessandro , Maggi Mario , Rochira Vincenzo , Corona Giovanni
Published: August 2021

Background: Hypogonadism is a common comorbidity in human immunodeficiency virus (HIV)-infected men, although the real prevalence is difficult to be estimated. Moreover, in HIV settings, the efficacy of exogenous testosterone (Te) administration at improving body composition remains unclear. Aim of the study: This review has a double aim. First, to estimate the prevalence of pituitary–testis axis abnormality in HIV-infected patients compared to uninfected subjects. Second, to evaluate the effect of androgen administration on body composition in HIV-infected men. Materials and Methods: A systematic review of the literature and meta-analysis was carried out. Two separated literature searches were performed, the first to evaluate the prevalence of Te deficiency in HIV-infected men and the second one to evaluate effects of androgen administration on body composition. Results: The overall prevalence of Te deficiency in HIV-infected men was calculated from 41 studies, showing a 26% prevalence, which was even higher when free T (fT) levels, more than total T, were considered. Indeed, TT serum levels were similar between HIV patients and controls, although higher SHBG and lower fT were detected in HIV populations. When HIV-infected men were treated with exogenous Te, a significant increase in body weight, lean body mass and fat free mass was detected. Conclusion: The systematic review confirms the high prevalence of Te deficiency in HIV-infected men, particularly when fT has been considered. Moreover, chronic androgen supplementation improves body composition, affecting the lean mass compartment. However, considering the general frailty of HIV patients, a tailored indication for Te therapy should be advocated.
The Chx10-Traf3 Knockout Mouse as a Viable Model to Study Neuronal Immune Regulation
Authors: Gurley Jami M. , Gmyrek Grzegorz B. , Hargis Elizabeth A. , Bishop Gail A. , Carr Daniel J. J. , Elliott Michael H.
Published: August 2021

Uncontrolled inflammation is associated with neurodegenerative conditions in central nervous system tissues, including the retina and brain. We previously found that the neural retina (NR) plays an important role in retinal immunity. Tumor necrosis factor Receptor-Associated Factor 3 (TRAF3) is a known immune regulator expressed in the retina; however, whether TRAF3 regulates retinal immunity is unknown. We have generated the first conditional NR-Traf3 knockout mouse model (Chx10-Cre/Traf3f/f) to enable studies of neuronal TRAF3 function. Here, we evaluated NR-Traf3 depletion effects on whole retinal TRAF3 protein expression, visual acuity, and retinal structure and function. Additionally, to determine if NR-Traf3 plays a role in retinal immune regulation, we used flow cytometry to assess immune cell infiltration following acute local lipopolysaccharide (LPS) administration. Our results show that TRAF3 protein is highly expressed in the NR and establish that NR-Traf3 depletion does not affect basal retinal structure or function. Importantly, NR-Traf3 promoted LPS-stimulated retinal immune infiltration. Thus, our findings propose NR-Traf3 as a positive regulator of retinal immunity. Further, the NR-Traf3 mouse provides a tool for investigations of neuronal TRAF3 as a novel potential target for therapeutic interventions aimed at suppressing retinal inflammatory disease and may also inform treatment approaches for inflammatory neurodegenerative brain conditions.
How to Support Child Healthcare Nurses in Sweden to Promote Healthy Lifestyle Behaviors from the Start of Life
Authors: Ersson Matilda , Henström Maria , Almquist-Tangen Gerd , Hesketh Kylie D. , Delisle Nyström Christine
Published: August 2021

Child healthcare (CHC) nurses have a key role in promoting and supporting healthy lifestyle behaviors from a young age. Thus, this study aims to investigate the perspectives of CHC nurses regarding discussing food introduction, physical activity/active play, and screen time with parents; explore facilitators and barriers influencing the discussion of healthy lifestyle behaviors with parents; and explore the perspectives of CHC nurses regarding a complementary program to promote healthy lifestyle behaviors from the start of life. A total of fifteen nurses participated in semi-structured interviews, which were recorded, transcribed verbatim, and analyzed using thematic analysis. There were four themes that were generated: parental needs; facilitators and barriers; parental groups; and future working methods. This study found that CHC nurses have seen an increase in the need for support among today’s parents. Time, the need to tailor information, and confidence to address sensitive topics were perceived as the largest barriers during daily work for the nurses. Furthermore, large variations in parental groups were found. Finally, the CHC nurses displayed a willingness and openness to change and develop current working methods using digital solutions. These solutions could possibly ease the workload and at the same time, support parents to create healthy lifestyle behaviors from the start of their child’s life.
Introduction to the Special Issue on Pediatric Acute Myeloid Leukemia: Current Management and Future Directions
Authors: Stevens Alexandra M. , Redell Michele S.
Published: August 2021

This Special Issue brings together an original research report, a fascinating case report, and three timely reviews on a variety of topics related to pediatric leukemia [...]
Impact of Synthetic Parameters on the Compressive Strength of Bagasse Ash-Clay Geopolymer
Authors: Amin Noorul , Gul Saeed , Sultana Sabiha , Alam Sultan , Naveed Amir
Published: August 2021

The impact of different parameters on the compressive strength of geopolymer synthesized from clay and bagasse bottom ash is reported. Geopolymer was synthesized from thermally activated clay and bottom bagasse ash using sodium silicate and sodium hydroxide as activator. The maximum dissolution of alumina and silica from the bagasse ash and clay maintaining different alkali conditions is studied. The resulting geopolymer synthesized under different conditions is studied for compressive strength. Different characterizations of the resulting geopolymer were carried out using different analytical instruments. The results indicated that the dissolution and strength of geopolymer have close relationships with the alkali concentration, solution to solid ratio and curing period. The highest compressive strength of 25 MPa was observed for 8M NaOH, 24 MPa for 0.3 solution to solid ratio, 30 MPa for 60% clay and 30 MPa for 27 days of compressive strength.
Intracerebral Hemorrhage, Visual Hallucination and COVID-19: What Is the Connection? A Case-Related Review of the Literature on Peduncular Hallucinosis Following Intracerebral Hemorrhage
Authors: Nagysomkuti Mertse Nicolas M. , Zenorini Lisa , Müri René
Published: August 2021

Previous publications have discussed the occurrence of intracerebral hemorrhages, hallucinations and psychosis in COVID-19 patients. In this article, we have reviewed the literature on the subject while depicting the case of a 63-year-old female patient who suffered from an intracerebral hemorrhage in the right basal ganglia and thalamus two weeks after a COVID-19 diagnosis and who developed a visual hallucinosis shortly after. We concluded that, while there may be a correlation between COVID-19 and hallucinations according to current literature, more research is yet needed to clarify. In our case, we rather interpreted the hallucinations in the context of a peduncular hallucinosis related to the intracerebral hemorrhage. We compared our patient’s lesion localization to other 15 reported cases of peduncular hallucinations following intracerebral hemorrhages reported on Pubmed. In summary, the lesions were localized in the pons in 52.9% of the cases, 17.7% were in the thalamus and/or the basal ganglia, 17.7% in the mesencephalon and respectively 5.8% in the temporal and occipital lobe. The distribution pattern we found is consistent with the previously proposed mechanism behind peduncular hallucinations.
Genetic Diversity and Differentiation of Pedunculate Oak (Quercus robur L.) Populations at the Southern Margin of Its Distribution Range—Implications for Conservation
Authors: Kesić Lazar , Cseke Klára , Orlović Saša , Stojanović Dejan B. , Kostić Saša , Benke Attila , Borovics Attila , Stojnić Srđan , Avramidou Evangelia V.
Published: August 2021

Understanding intraspecific genetic variation is one of the principal requirements for the evaluation of tree species capacity to cope with intensive climatic changes, as well as designing long-term conservation programs. Herein, we evaluated the genetic diversity and genetic structure of seven pedunculate oak (Quercus robur L.) populations, located at the southern margin of its distribution range on the Balkan Peninsula (Serbia). The objective of the study was to propose future in situ conservation measures aimed at protection of pedunculate oak adaptive and neutral genetic diversity at the species rear-edge. Genetic diversity and structure were estimated using twelve highly polymorphic simple sequence repeat (SSR) markers. The mean expected heterozygosity (He) was 0.769, allelic richness (AR) 9.63, and private allelic richness (pAR) 0.79, indicating high genetic diversity in the studied populations. Genetic differentiation among the populations was low (Fst = 0.032). Structure analysis, the unweighted pair group method with arithmetic mean (UPGMA) showed the existence of two gene pools unrelated to the populations’ area of occurrence. Taking into consideration the results of the current study and previous conservation activities on the pedunculate oak in Serbia, as well as the importance of rear-edge populations in the long-term conservation of the species genetic diversity, we suggested establishing three additional gene conservation units for securing long-term sustainability of the species.
KnowRU: Knowledge Reuse via Knowledge Distillation in Multi-Agent Reinforcement Learning
Authors: Gao Zijian , Xu Kele , Ding Bo , Wang Huaimin
Published: August 2021

Recently, deep reinforcement learning (RL) algorithms have achieved significant progress in the multi-agent domain. However, training for increasingly complex tasks would be time-consuming and resource intensive. To alleviate this problem, efficient leveraging of historical experience is essential, which is under-explored in previous studies because most existing methods fail to achieve this goal in a continuously dynamic system owing to their complicated design. In this paper, we propose a method for knowledge reuse called “KnowRU”, which can be easily deployed in the majority of multi-agent reinforcement learning (MARL) algorithms without requiring complicated hand-coded design. We employ the knowledge distillation paradigm to transfer knowledge among agents to shorten the training phase for new tasks while improving the asymptotic performance of agents. To empirically demonstrate the robustness and effectiveness of KnowRU, we perform extensive experiments on state-of-the-art MARL algorithms in collaborative and competitive scenarios. The results show that KnowRU outperforms recently reported methods and not only successfully accelerates the training phase, but also improves the training performance, emphasizing the importance of the proposed knowledge reuse for MARL.
On Supervised Classification of Feature Vectors with Independent and Non-Identically Distributed Elements
Authors: Shahrivari Farzad , Zlatanov Nikola
Published: August 2021

In this paper, we investigate the problem of classifying feature vectors with mutually independent but non-identically distributed elements that take values from a finite alphabet set. First, we show the importance of this problem. Next, we propose a classifier and derive an analytical upper bound on its error probability. We show that the error probability moves to zero as the length of the feature vectors grows, even when there is only one training feature vector per label available. Thereby, we show that for this important problem at least one asymptotically optimal classifier exists. Finally, we provide numerical examples where we show that the performance of the proposed classifier outperforms conventional classification algorithms when the number of training data is small and the length of the feature vectors is sufficiently high.
Sub-Transient Response of the DSC Controlled Inverter under Fault
Authors: Popadic Bane , Dumnic Boris , Milicevic Dragan , Strezoski Luka , Petrovic Natasa
Published: August 2021

The most important element of the new active distribution system concept is the grid connected converter that needs to offer fault ride through capabilities. The new system topologies require new tools for fault state calculation that would consider different control methodologies. In that regard, this paper investigates the initial response of the grid connected inverter under fault that operates using new control methodology based on the integration of the delay signal cancellation. Using modern laboratory setup for testing of renewable energy sources and their integration in the power system the technique is weighed against the classical technique that does not provide the adequate control under unbalanced faults. Furthermore, through a set of specific experiments the paper demonstrates the behavior of the converter under fault, preparing the outline for the fault response modeling of distributed energy resources. Experimental results present the sub-transient period and the transient period of the response, giving the attention to the inrush current (initial peak current) of the converter. It has been shown that the new technique has similar behavior as the classical control for the balanced faults (symmetrical voltage states), while the values of the peak current for different type of unbalanced faults (asymmetrical voltages where classical technique can be proven to be ineffective) has also been demonstrated.
Model Predictive Control with Modulator Applied to Grid Inverter under Voltage Distorted
Authors: Lunardi Angelo , Conde D Eliomar R. , de Assis Jefferson , Fernandes Darlan A. , Sguarezi Filho Alfeu J.
Published: August 2021

This research paper presents a model of predictive control with a modulator for the inverter linked to the electrical grid, using the stationary reference frame and operating under grid distorted voltage. The stationary reference frame model for the system is obtained in its fundamental frequency and then the model predictive technique is implemented, which predicts the system actions using the obtained system model without the need of any other harmonic consideration. The controller calculates the voltage vector of the inverter through the minimization of the cost function. Thus, the proposal demonstrates, through experiments, its positive results regarding the low impact of the distorted voltage in the grid current without using any harmonic consideration on the model. Experimental results and comparisons carried out endorse the proposal of this work.
The Influences of NP100 Surfactant and Pine-Oil Concentrations on Filtrate Volume and Filter-Cake Thickness of Microemulsion-Based Drilling Fluids (O/W)
Authors: Junior Agostinho C. B. , Silva Raphael R. , Leal Giovanna L. R. , Tertuliano Tarsila M. , Alves Rafael P. , Garnica Alfredo I. C. , Curbelo Fabiola D. S.
Published: August 2021

In this work, nonionic surfactant NP100 and pine oil influences on the filtrate volume (FV) and the filter-cake thickness (thkns) of microemulsified drilling fluids were studied. A ternary phase diagram was obtained to define the microemulsion region, where a 2k factorial design was used with the addition of four center points and axial points. Twelve microemulsion points were defined and used later in the formulation of the investigated drilling fluids. The results showed that the increase in the surfactant and pine oil’s concentration increased FV and thkns, withthe oil phase being the most influential component in the filtrate volume and the surfactant being the most influential in the filter-cake thickness. Statistically significant models were obtained. The optimal concentrations were determined for the lowest FV and thkns; 45% of surfactant and 5% of pine oil for the filtrate volume (1.3 mL), and 45% of surfactant and 15% of pine oil for the filter-cake thickness (0.64 mm).
Numerical Study and Experimental Validation of Skim Milk Drying in a Process Intensified Counter Flow Spray Dryer
Authors: Jamil Ur Rahman Umair , Pozarlik Artur K.
Published: August 2021

This research presents 3D steady-state simulations of a skim milk spray drying process in a counter-current configuration dryer. A two-phase flow involving gas and discrete phase is modeled using the Eulerian–Lagrangian model with two-way coupling between phases. The drying kinetics of skim milk is incorporated using the Reaction Engineering Approach. The model predictions are found to be in accordance with the experimental temperature measurements with a maximum average error of 5%. The validated computational model is employed further to study the effects of nozzle position, initial spray Sauter Mean Diameter (SMD), air inlet temperature, and feed rate on the temperature and moisture profiles, particle impact positions, drying histories, and product recovery at the outlet. The location of the nozzle upwards (≈23 cm) resulted in maximum product recovery and increased the mean particle residence time at the outlet. A similar trend was observed for the highest feed rate of 26 kg/h owing to the increased spray penetration upstream in the chamber. The maximum evaporation zone was detected close to the atomizer (0–10 cm) when the spray SMD is 38 µm, whereas it shifts upstream (40–50 cm) of the dryer for an SMD of 58 µm. The high air inlet temperature resulted in enhanced evaporation rates only in the initial 10–20 cm distance from the atomizer. The results obtained in this study are beneficial for the development of the novel vortex chamber-based reactors with a counter flow mechanism.
The Review of Carbon Capture-Storage Technologies and Developing Fuel Cells for Enhancing Utilization
Authors: Shreyash Nehil , Sonker Muskan , Bajpai Sushant , Tiwary Saurabh Kr , Khan Mohd Ashhar , Raj Subham , Sharma Tushar , Biswas Susham
Published: August 2021

The amount of CO2 released in the atmosphere has been at a continuous surge in the last decade, and in order to protect the environment from global warming, it is necessary to employ techniques like carbon capture. Developing technologies like Carbon Capture Utilization and Storage aims at mitigating the CO2 content from the air we breathe and has garnered immense research attention. In this review, the authors have aimed to discuss the various technologies that are being used to capture the CO2 from the atmosphere, store it and further utilize it. For utilization, researchers have developed alternatives to make profits from CO2 by converting it into an asset. The development of newer fuel cells that consume CO2 in exchange for electrical power to drive the industries and produce valuable hydrocarbons in the form of fuel has paved the path for more research in the field of carbon utilization. The primary focus on the article is to inspect the environmental and economic feasibility of novel technologies such as fuel cells, different electrochemical processes, and the integration of artificial intelligence and data science in them, which are designed for mitigating the percentage of CO2 in the air.
Transcriptome Profile Analysis Reveals the Regulation Mechanism of Stamen Abortion in Handeliodendron bodinieri
Authors: Liu Xiatong , Liu Tianfeng , Zhang Chong , Guo Xiaorui , Guo Song , Lu Hai , Li Hui , Li Zailiu
Published: August 2021

Handeliodendron bodinieri has unisexual flowers with aborted stamens in female trees, which can be used to study unisexual flower development in tree species. To elucidate the molecular mechanism of stamen abortion underlying sex differentiation, the stage of stamen abortion was determined by semi-thin sections; results showed that stamen abortion occurred in stage 6 during anther development. In addition, differentially expressed transcripts regulating stamen abortion were identified by comparing the transcriptome of female flowers and male flowers with RNA-seq technique. The results showed that 14 genes related to anther development and meiosis such as HbGPAT, HbAMS, HbLAP5, HbLAP3, and HbTES were down-regulated, and HbML5 was up-regulated. Therefore, this information will provide a theoretical foundation for the conservation, breeding, scientific research, and application of Handeliodendron bodinieri.
Responses of Visual Forms to Neighboring Competition: A Structural Equation Model for Cotinus coggygria var. cinerea Engl.
Authors: Cao Yujuan , Zhu Jiyou , Xu Chengyang , Hauer Richard J.
Published: August 2021

Background: The visual forms of individual trees in peri-urban forests are driven by a complex array of simultaneous cause-and-effect relationships. Materials and Methods: Structural Equation Modeling (SEM), as a specialized analytical technique, was used to model and understand the complex interactions. It was applied to find out responses of visual forms to neighboring competition in a peri-urban forest dominated by Cotinus coggygria var. cinerea Engl. in Beijing, China. Research Highlights: Light interception and space extrusion have substantial effects on visual forms, expressed as crown forms and foliage forms. The structural model in SEM tested hypothetical correlations among latent variables, namely neighboring competition, crown forms, and foliage forms. Results: The fitted model suggested a direct negative effect of neighboring competition on crown forms and an insignificant negative direct effect on foliage forms. Moreover, an indirect positive effect on foliage forms mediated by crown forms was revealed. Conclusions: The fitted SEM and associated findings should facilitate peri-urban forest landscape management by providing insight into causal mechanisms of visual forms of individual trees and thereby assisting in the visual quality promotion.
cfDNA Changes in Maximal Exercises as a Sport Adaptation Predictor
Authors: Humińska-Lisowska Kinga , Mieszkowski Jan , Kochanowicz Andrzej , Stankiewicz Błażej , Niespodziński Bartłomiej , Brzezińska Paulina , Ficek Krzysztof , Kemerytė-Ivanauskienė Eglė , Cięszczyk Paweł
Published: August 2021

Changes of circulating free plasma DNA (cfDNA) are associated with different types of tissue injury, including those induced by intensive aerobic and anaerobic exercises. Observed changes are dependent from induced inflammation, and thus it may be a potential marker for athletic overtraining. We aimed to identify the response of cfDNA to different types of exercise, with association to exercise intensity as a potential marker of exercise load. Fifty volunteers (25 athletes and 25 physically active men) were assigned to the study and performed maximal aerobic (Bruce test) and anaerobic (Wingate Anaerobic Test) test. Blood samples for cfDNA analysis were collected at four time-points: before, 2–5 min after, 30 min after and 60 min after each type of maximal physical activity. The two-way ANOVA revealed a significant effect of group factor on serum cfDNA concentrations (32.15% higher concentration of cfDNA in the athletes). In turn the results of the post hoc test for the interaction of the repeated measures factor and the group showed that while the concentration of cfDNA decreased by 40.10% in the period from 30 min to 60 min after exercise in the control group, the concentration of cfDNA in the group of athletes remained at a similar level. Our analysis presents different responses depending on the intensity and duration of exercise. Our observations imply that formation of cfDNA is associated with response to physical activity but only during maximal effort.
Tectonic and Stratigraphic Evolution Based on Seismic Sequence Stratigraphy: Central Rift Section of the Campos Basin, Offshore Brazil
Authors: Alvarenga Renata dos Santos , Kuchle Juliano , Iacopini David , Goldberg Karin , Scherer Claiton Marlon dos Santos , Pantopoulos George , Ene Patrycia Leipnitz
Published: August 2021

The rift section of the Brazilian basins represent the sedimentary record associated with the first stages of Gondwana break-up in the Early Cretaceous phase (Berriasian to Aptian). The rift succession of the Campos Basin constitutes one of the main petroleum systems of Brazil’s marginal basins. This interval contains the main source rock and important reservoirs in the Lagoa Feia Group deposits. The Lagoa Feia Group is characterized by siliciclastic, carbonate and evaporite sediments deposited during the rift and post-rift phases. Despite the economic relevance, little is known in stratigraphic terms regarding this rift interval. To date, most studies of the Lagoa Feia Group have adopted a lithostratigraphic approach, while this study proposes a tectonostratigraphic framework for the deep-rift succession of the Campos Basin (Lagoa Feia Group), using the fundamentals of seismic sequence stratigraphy. This work also aims to establish a methodological and practical procedure for the stratigraphic analysis of rift basins, using seismic data and seismofacies, and focusing on tectonicstratigraphic analysis. The dataset comprised 2D seismic lines, core and lithological logs from exploration wells. Three seismic facies were identified based on reflector patterns and lithologic data from well cores, providing an improved subdivision of the pre-, syn- and post-rift stages. The syn-rift stage was further subdivided based on the geometric patterns of the reflectors. Tectonics was the main controlling factor in the sedimentary succession, and the pattern and geometry of the seismic reflectors of the syn-rift interval in the Campos Basin allowed the identification of three tectonic systems tracts: (i) a Rift Initiation Systems Tract; (ii) a High Tectonic Activity Systems Tract and (iii) a Low Tectonic Activity Systems Tract.
Barriers to Discharge in Geriatric Long Staying Inpatient and Emergency Department Admissions: A Descriptive Study
Authors: Keverline Kelsey J. , Mow Steve J. , Cyr Julianne Maire , Platts-Mills Timothy , Brice Jane H.
Published: August 2021

Background: This study describes long length of stay during emergency department (ED) visits and hospital admissions, barriers to discharge, and discharge solutions for geriatric patients. Methods: We conducted a retrospective medical record review of a random sample of 150 ED patients and 150 inpatients with long length of stay (LOS) encounters. Cohorts were characterized by demographics, social determinants of health (e.g., health insurance, housing), medical comorbidities at admission, discharge care coordination, and final disposition. Results: In the ED, the primary barrier to discharge was inadequate inpatient bed availability (63%). In the inpatient setting, barriers to discharge were predominantly due to a demonstrated medical requirement for continued hospitalization (55%), followed by difficulty with coordinating discharge to a skilled nursing facility or rehabilitation center (22%). Discussion: Among long LOS ED patients, discharge delays were often the result of unavailable inpatient beds and services. Reducing the LOS for ED patients may require further investigation as to which hospital services are most frequently utilized by geriatric patients and structuring inpatient bed allocation to prevent extended patient boarding in the ED. Reducing long inpatient LOS may require early identification of high-risk patients and strengthening of relationships with community-based services.
Multispectral Analysis of Miniature Nuragic Bronze Flasks
Authors: Nocco Carlo , Assunta Pisu Francesca , Chiriu Daniele , Depalmas Anna , Barcellos Lins Sergio Augusto , Brunetti Antonio
Published: August 2021

Miniaturized bronze flasks represent a small portion of a wide metallurgical production that flourished in Sardinia (Italy) between the Final Bronze Age (FBA) and the Early Iron Age (EIA). They replicate a well-known and symbolic type of object, the pilgrims’ flask, common in all Europe and Mediterranean basin, and have but few archaeological parallels. For these reasons, their characterization can be considered important from an archaeological perspective. Three flasks, preserved at the Antiquarium Arborense museum (Oristano), were analyzed by X-Ray Fluorescence Spectroscopy (XRF) and Raman spectroscopy, integrated by multispectral images. The samples, coming from illegal excavations, posed two problems: establishing their authenticity and investigating the alloy composition of such particular objects. All specimens presented a widespread degradation in the outer surface: XRF and Raman spectroscopy indicated the presence of copper oxides, calcium and copper carbonates deposits. The abscence of Zn, a clear marker of forgeries, was not detected by XRF. In two of the flasks, an unusual Sn content above 20%, was detected. For FBA and EIA, especially regarding southern Europe, Sn was extremely rare, and was possibly used with caution. Further results are presented herein.
Archaeology, The Academy, and Women: Finding One’s Own Path
Authors: Chase Diane Z.
Published: August 2021

While women have long been key to archaeological research, the role of women and women’s voices have grown substantially in the last 50 years. Once predominantly found in the laboratory rather than in the field, women archaeologists are driving the discipline forward through field work and analysis. Similar developments are taking place throughout higher education in both academics and in leadership. At the same time, work on the engendered past is also evolving. However, more needs to be done. Issues in the field, particularly injustices done toward women associated with fieldwork, are coming to the forefront, hopefully assuring a future with higher ethical standards. The personal stories of female archaeologists help provide context to the past as well as opportunities for the future of archaeology.
Study of Materials and Technique of Late Baroque Stucco Decorations: Baldassarre Fontana from Ticino to Czechia
Authors: Caroselli Marta , Válek Jan , Zapletalová Jana , Felici Alberto , Frankeová Dita , Kozlovcev Petr , Nicoli Giovanni , Jean Giacinta
Published: August 2021

From the 16th to the 18th century, many artists and craftspeople coming from villages in the Italian-speaking part of Switzerland, well known for its stucco tradition, worked actively in Central Europe. Baldassarre Fontana (Chiasso 1661–1733) was one of them; after a period in Rome, he was active in Moravia and Poland. This contribution presents an analytical insight into stucco works in the Ticino canton and Czech lands in order to provide an understanding of how artistic and technical skills were transferred according to local traditions, materials, or other requirements found abroad. By comparing two works that Fontana realized in his homeland and two works that he realized in today’s Czech Republic, the historic techniques used to make stucco are characterized, with an emphasis on technological aspects and materials. The detailed analyses provide information on materials and their production and processing methods in relation to the specific sites. They also reveal certain specific technological approaches which were common in all four cases that were studied. The most significant was the layered system of high-relief pieces, where the ground layer was made of lime–gypsum mortar and the finishing layer was pure air lime mortar. The construction of the finishing layer differed between the Czech and Swiss sites, suggesting some other influential factors.
Comparative Study of CO2 Capture by Adsorption in Sustainable Date Pits-Derived Porous Activated Carbon and Molecular Sieve
Authors: Danish Mohd , Parthasarthy Vijay , Al Mesfer Mohammed K.
Published: August 2021

The rising CO2 concentration has prompted the quest of innovative tools to reduce its effect on the environment. A comparative adsorption study using sustainable low-cost date pits-derived activated carbon and molecular sieve has been carried out for CO2 separation. The adsorb ents were characterized for surface area and morphological properties. The outcomes of flow rate, temperature and initial adsorbate concentration on adsorption performance were examined. The process effectiveness was investigated by breakthrough time, adsorbate loading, efficiency, utilized bed height, mass transfer zone and utilization factor. The immensely steep adsorption response curves demonstrate acceptable utilization of adsorbent capability under breakthrough condition. The adsorbate loading 73.08 mg/g is achieved with an 0.938 column efficiency for developed porous activated carbon at 298 K. The reduced 1.20 cm length of mass transfer zone with enhanced capacity utilization factor equal 0.97 at 298 K with Cin = 5% signifies better adsorption performance for date pits-derived adsorbent. The findings recommend that produced activated carbon is greatly promising to adsorb CO2 in fixed bed column under continuous mode.