bluuebunny/crossref_metadata_2025 huggingface dataset:
Preliminary Cytotoxic Study of Some Novel Furo-2-quinolone Compounds
Authors: A.AlOmari Nohad , O. Omar Adnan , M. Taher Iklas
Published: March 2022

In this research, new series of Furo-2-quinolone [FQ] compounds have been synthesized. These novel [FQ] compounds were prepared from coumarin derivatives (Furocoumarins: psoralen and isopsoralen).Identifications of these FQ compounds were performed by using infrared spectrum (I.R), Ultraviolet spectrum (U.V) and Nuclear Magnetic Resonance spectrum (H1-NMR) besides some physical data. The cytotoxic screening involves ;using HEP-2 cell line which gave differential responses against tested compounds : 4,6 Dimethyl furo[2, 3-g] coumarin (C1), 1-(2`, 4`, Dimethoxy benzylideneimino)-2,6-dimethyl Furo [2, 3-g] quinoline-2-one (C3) and the angular psoralen of the same derivative with the chemical name; 1-(2`,4`-Dimethoxybenzylidenimine)-4,8,9-trimethyl furo[3,2-h] quinoline-2-one (C3A).These preliminary studies using different cell lines in addition to full cytotoxic screening may facilitate generation of better structural activity relationship and then shed the light for new lead promising anticancer compounds.

Keyword: Coumarin, Angelicin, HEP-2 Cell line, cytotoxicity,
Preventive Effects of Different Doses of Pentoxyfilline Against CCl4-Induced Liver Toxicity in Rats
Authors: I. Abd Al-Zahra Jameel , K. Ismael Dawser , N. Al-Shawi Nada
Published: March 2022

The liver protective effects of pentoxifylline were studied through pre-treatment of rats with various intraperitoneal (IP) doses (25, 50 and 100mg/kg/day) 14 days before induction of liver toxicity by carbon tetrachloride (CCl4). The parameters of oxidative stress, malondialdehyde (MDA) and reduced glutathione (GSH) were measured in liver homogenate in addition to histopathological examinations.  Analysis of data revealed significant amelioration of oxidative stress in groups of animals pre-treated with different doses of pentoxifylline (PTX) compared to group of animals intoxicated by CCl4 as evidenced by lowering MDA contents and elevation of GSH levels in liver tissue homogenate but the levels still significantly different compared to controls. Additionally, increasing doses of PTX produce a dose-dependent improvement in liver tissue damage induced by CCl4, as evident histologically by the stained liver sections. In conclusion, these findings suggest that, the hepatoprotective effects of pentoxifylline are dose dependent.

Key words: pentoxifylline, CCl4Â­, liver toxicity.
Quantitative and Qualitative Analysis of Plumbagin in the Leaf and Root of Plumbago europaea Growing Naturally in Kurdistan by HPLC
Authors: M. Muhammad Hazhar , Y. Saour Kawkab , M. Naqishbandi Alaadin
Published: March 2022

Plumbago (Plumbaginaceae) is a genus of 10-20 species of flowering plants used in traditional Indian medicine, native to warm temperature to tropical regions of the world. The roots of Plumbago europaea, the Iraqi species of Plumbago, have been used for the treatment of cancer, rheumatoid arthritis, and dysmenorrhea. The main active constituents from dried powdered leaves and roots of Plumbago europaea were extracted by Soxhlet apparatus using ethyl acetate, the main active constituent was characterized by spectroscopic analysis (IR, 1H NMR, and 13C NMR)   as plumbagin. Quantitative and qualitative study of plumbagin in the roots and leaves extracts was carried out by HPLC technique  using analytical column (Eurospher 100, C18, 5 Âµm, 250 x 4.6 mm)  with 10% solvent (B) isocratic elution of methanol (solvent A) and water (solvent B) at flow rate 0.75 ml/min and detection wave length of 270 nm. The percentage of plumbagin in the root and leaf extracts was recorded to be (1.9 %) and (1.5 %) respectively.

Keywords: Plumbago europaea, plumbagin, HPLC
Detecting Meaninglessness and Meaning in Don DeLillo’s Players
Authors: Tyers Rhys William
Published: March 2022

This article discusses Don DeLillo’s Players as a critique of the media and the extent to which our lives are shaped and influenced by our interaction with the detective and thriller genres. Drawing upon Baudrillard’s definition of the hyperreal and Jameson’s understanding of postmodernity, I explore the novel’s depiction of Lyle and Pammy Wynant’s journey as a reaction against the controlling nature of the media, and the couple’s experience of the world through the detective and thriller genres. I argue that DeLillo’s Players provides penetrating insights into the extent to which our postmodern cultural moment is deadly to the individual. I suggest that the defining features of the novel’s characters are their subjection to the anonymizing processes of the media and their sense of dissatisfaction and yearning for escape and adventure.
O Estado da Arte sobre alimentação na revista Oikos
Authors: De Souza Lima Romilda
Published: March 2022

Este texto, componente do número comemorativo dos 40 anos da Revista OIKOS – Família e Sociedade em Debate, tem como objetivo abordar a trajetória dos artigos sobre alimentação, nutrição e comida desde o primeiro número, publicado em 1981. Todos os volumes encontram-se disponíveis no site da Revista, inclusive aqueles mais antigos, haja vista terem sidos digitalizados para PDF. Foram encontrados 103 artigos sobre o tema. O ano de 2001 foi aquele em que mais foram publicados temas sobre alimentação na Revista. Foram 9 artigos sobre o tema: 7 em suplemento especial e outros 2 no segundo número do referido ano. Na sequência, aparecem os anos de 1981, 1983, 1990 e 2013 com 5 artigos por ano sobre o tema. É perceptível a redução paulatina das publicações na área de alimentação a partir de 1992 (desconsiderando 2001, cujas publicações foram resumos de dissertações defendidas no PPGED, como já apontado.
LAND ADMINISTRATION AUTOMOBILE TRANSPORT AND ROAD FACILITIES IN THE CONTEXT OF ENVIRONMENTAL SAFETY: THE EXPERIENCE OF UKRAINE
Authors: Balian Anush  , Iryna Novakovska  , Nataliia Ishchenko  , Liliia Skrypnyk  , Stetsyuk Mykhail
Published: March 2022

The article considers the impact of emissions from mobile sources of environmental pollution and human health. The dynamics of morbidity of the population due to inhalation of extremely polluted air from various sources, including transport, has been determined. The content of the state policy of Ukraine in the sphere of environmentally friendly use of land of road transport and road facilities has been formed. The features of land management in the performance of land management works on the use of land of road transport and road facilities are allocated. The main types of land management works on the placement, construction and operation of roads, which is a complex land management and legal procedure, are considered. There are proposals to improve the mechanism for approving land management documentation for the allocation of land for placement, construction and operation of road facilities.
MİZAHTA ÜSTÜNLÜK KURAMI BAĞLAMINDA KAYSERİLİ-YAHUDİ FIKRALARI
Authors: ERŞAHİN İbrahim , VİŞNE Fatma
Published: March 2022

Mizah diğer işlevlerinin yanında kişisel ve toplumsal rekabetin bir aracı olarak da kullanılagelmiştir. Mizahın rekabet aracı oluşu onun varlığını irdeleyen kuramlarda da kendine yer bulur. Özellikle “üstünlük kuramı” bunu ifade eder. Bu kurama göre ise hayatta mizahi bir durumla karşı karşıya kalan kimse/toplum, bunun öznesi olan kişi/kişilerin yaptığı uygunsuz davranışı kendilerinin yapmayacağı öz güveniyle hareket etmektedir. Buradaki davranış bir eksiklik ve zaafın göstergesidir. Dolayısıyla kendisinde bu eksikliğin bulunmadığı öz güveniyle hareket eden mizah muhatabı bunu aynı zamanda bir “üstünlük” sebebi olarak görmektedir. Böylesi bir kabul de bu durumu onun için kişilerarası ve toplumlararası ilişkilerde önemli bir koz veya avantaj olarak görmesi ve kullanması anlamına gelir. İnsan ve toplumla ilgili hemen her durum gibi kişilerarası ve toplumlararası ilişkilerdeki bu mizah-rekabet olgusu, mizahi bir halk anlatısı olan fıkralarda da kendine yer bulmuştur. Daha doğru bir ifadeyle bu olgu fıkralarda sıklıkla dile getirilmiştir.
Bir “tip” özelliği kazanmış olan fıkra kişileri tekil kimliklerinin ötesinde “temsili/sembolik” bir özellik taşımaktadırlar. Bu konumlarıyla da yer aldıkları “taraf”ın temsilcileri durumundadır ve eksileri-artıları onlar hesabına geçer. Bunun tipik bir örneği sayılabilecek olan Kayserili-Yahudi tipine bağlı fıkralar, tarafların rekabetinin bir platformu durumundadır. Tarafların ticari hayattaki konumu rekabetin odak noktasını oluşturur. Türk halk kültüründe ve fıkralarında “Yahudi” genelde tekil bir tip olarak kendini gösterir. Bununla beraber Kayserili-Yahudi örneğinde olduğu gibi ikililerden biri veya “alt tip” durumunda da görülür. Çalışmamızda da bu tipolojideki fıkralar söz konusu edilmiştir.
An intellectual system for supporting decision making in the control of the borring process
Authors: Shavranskii M. V. , Sheketa V. I. , Shavranskii V. M.
Published: March 2022

The problem of development of the method of identification of complications arising in the process of drilling of oil and gas wells, which operates under the conditions of a priori and current uncertainty under the influence of various perturbations based on methods of fuzzy set theory and fuzzy logic, is considered.
A methodological approach to the estimation of the level of complications in the drilling of oil and gas wells, based on the principles of linguistic parameters of the drilling process, linguistic and hierarchical knowledge about the complications in the drilling of wells is proposed.
Mathematical models of a controlled object have been developed that, unlike deterministic mathematical models, allow to describe in natural language the cause and effect relationships between the parameters of the drilling process and the possible complication. These models reflect the logic of the operator's reasoning with the involvement of non-numerical and fuzzy information from an expert to formalize Fuzzy Logic decision-making procedures using the parameters and indicators of the oil and gas drilling process.
The structure of the decision support system for controlling the drilling of wells in the conditions of complications is proposed.
The results of simulation modeling of the developed methods of modeling of complications based on the methods of fuzzy set theory and fuzzy logic are presented. Their advantages over the well-known in accuracy of the tasks of identification of an estimation and control in the conditions of uncertainty concerning structure and parameters of object are shown.
The real complications have been identified, the elimination of which will increase the level of safety of the drilling process. It is shown that the developed methods and models can find application for modeling and identification of a wide class of complications on drilling rigs operating under the conditions of a priori and current uncertainty regarding their structure, parameters and geographic environment.
The natural gas combustions higher heat measuring possibility modeling for the available informative parameters
Authors: Rybitskyi I. V. , Karpash O. M. , Karpash M. O.
Published: March 2022

The impact of our state's commitments on the implementation of the Third Energy Package on the gas market is considered. It is shown that the lack of natural gas consumers information about the amount and cost of energy consumed creates certain problems in the formation of the gas market. The currently existing methods and technical means that implement them to determine the energy characteristics of natural gas are described, as well as a list of regulations governing this activity. The necessity of improving the existing methods and technical means of measuring the heat of combustion of natural gas in order to ensure their operability on low pressure gas networks is proved. Measuring the quality of natural gas (its calorific value) is a complex and expensive process. As a rule, it is currently measured only by the gas transmission and gas supply companies at the point of entry and exit of the gas transmission system, as well as at individual points at the level of gas distribution stations. Measurements are made using industrial flow or stationary laboratory chromatographs, which cost hundreds of thousands of euros. In addition, the maintenance of such chromatographs is expensive, and their work requires highly qualified workers. Such measurements are not available to the average household consumer mainly due to the cost of measuring one sample, which can reach tens of thousands of hryvnias, and therefore he can be satisfied only with the information provided to him by the gas supply organization. In such a scheme of supplier-consumer relationship lies a conflict of interest, because the organization that sells gas itself and determines (measures) its quality. An analysis of recent research in the field of natural gas quality control, in particular its calorific value, has shown that the most promising in terms of cost and applicability in different areas of gas transportation, from production to consumption, are correlation methods.
A new correlation was obtained between the physicochemical properties of natural gas (the rate of propagation of ultrasonic vibrations and the content of carbon dioxide in the sample of natural gas) and the higher heat of combustion of natural gas. The method of natural gas combustion heat control has been improved, measurement accuracy has been increased and functionality has been expanded.
The downhole jet pumps experimental studies efficiency improving
Authors: Kryzhanivskyy Ye. І. , Panevnyk D. O.
Published: March 2022

On the basis of the analysis of the existing criteria of hydraulic similarity, the rules of transferring the results of laboratory tests of jet pumps to the conditions of their operation in the well are considered.  The geometric similarity of the flow part of the jet pump is determined by the diameters of the working nozzle, the mixing chamber and the diffuser, the lengths of the mixing chamber and the diffuser, and the distance between the working nozzle and the mixing chamber.  The kinematic similarity of mixed flows is determined by the ratio of the speeds or costs of the injected and the workflows, and the dynamic one by the relative pressure in the form of the pressure ratio of the mixed, injected and workflows.  To characterize the similarity of motion modes and physical properties of flows in the flowing portion of a jet pump, a Reynolds number for working, injected, and mixed flows can be used.  The functional relationship between the quantities that characterize the process of mixing threads can be represented as a relationship between the similarity criteria that are made of them.  The equality of any two relevant similarity criteria made up of the basic parameters and initial boundary conditions is a sufficient sign of the similarity of the two systems.  A generalized Eulerian criterion is proposed for modeling a wellbore jet pump workflow that provides a relationship between geometric, kinematic, and dynamic dimensionless complexes.  Due to the structural features of the ejection systems, the generalized criterion is presented in the form of a ratio of Euler criteria of mixed and working flows, the numerical values of which do not differ from the magnitude of the relative pressure of the jet pump.  As a result of the conducted researches, the values ​​of dimensionless complexes are determined, which determine the conditions for transferring the results of experimental studies of the jet pump model to the real design of the well ejection system.
The metal structures technical diagnostics system by acoustuc emission method control process automation models and schematic solution
Authors: Sharko A. O.
Published: March 2022

The need to develop hardware for the technical diagnostics of the strength properties of metal structures is explained by the need for continuous monitoring of the state of industrial objects in the systems of technical diagnostics, which allow to record the force response to changes caused by changes in the loading conditions of the material structure. The current state of technical diagnostics equipment is considered. It is proved that the main principle of control automation in the systems of technical diagnostics of the strength properties of materials by acoustic emission methods is the detection and identification of signals, their amplification, frequency filtering, discrimination and normalization of pulses in duration and amplitude. The use of these operations allows the automated passport system to process the primary data in real time and to perform an integrated assessment of the state of the object at different stages of its life cycle. A structural diagram of the receiving equipment for measuring acoustic emission parameters, a number of designs of acoustic sensors and hardware for processing acoustic emission signals, which guarantee high quality performance of metal structures. On the basis of the analysis of modern and foreign equipment, which became widespread in the practice of technical diagnostics by the method of acoustic emission, the directions of formation of the acoustic tract of diagnostic equipment and the basic requirements for the design of the recording equipment are formulated. It is established that information support of automated systems of control and diagnostics of metal structures requires determination of their informative parameters. It is proved that the main characteristic of diagnostics of the state of metal structures in the course of their operation is the flow of AE signals, which is determined by the average value of the pulse amplitude, the dispersion of the amplitude, the amplitude distribution, the amplitude frequency distribution of time intervals between pulses. The recovery of information obtained by the diagnostic system from the AE source is the basic principle of the construction of automated control systems and diagnostics of metal structures.
Analysis of energy flows in the power supply system with a thyristor voltage converte
Authors: Grabchuk B. L. , Romaniuk Yu. F.
Published: March 2022

A numerical analysis of energy flows in a three-phase power supply system with a sine wave EMF source, active load and a thyristor converter that distorts the sine waveform and generates higher harmonics is performed. The influence of the thyristor non-sinusoidal voltage  on the energy flows and the power factor of the source is analyzed. Thyristor converter is considered as a nonlinear electric power unit consuming electricity from the primary power source at a fundamental frequency, part of which is converted and returned back to the network as a secondary energy stream of zero-sequence systems and higher harmonics, thereby reducing the overall power factor and the quality of electricity becomes worse. It is analyzed the influence of the considered harmonics quantitative composition  on the accuracy of the currents and voltages calculations. The dependence of the  higher harmonics amplitudes on the thyristor firing angle  is established. The constant component and the 2nd order harmonic voltage are the most denoted in the thyristor harmonics spectrum. In general case it is shown that in the nonlinear circuit with a sinusoidal power source, even in the absence of inductive and capacitive electric load, the fundamental  current harmonic of the power source does not coincide in phase with the sinusoidal EMF of the source. Thus, the thyristor can be considered as a reactive inductive element that consumes reactive power of the fundamental frequency of current, regardless of the its firing angle and the presence of other reactive elements in the system. Therefore, in order to increase the power factor, it is necessary to compensate the reactive power of displacement only at the current fundamental frequency, which should be recorded by electronic meters. It is proposed to use the relative current value of the first harmonic of the power source to characterize the effect of the secondary energy flow on the total power factor. In a four-wire network, the presence of a thyristor converter causes a significant current increasing in the neutral wire, even under symmetrical phase loading, due to the zero sequence currents flowing, which are multiple of three, and they must be taken into account during wire cross-section selection  and  power losses calculation. It is proposed the practical measures to limit the level of higher harmonics and improve the electricity quality.
The wells fluking hydraulic system elements dinamics system analysis and modelling for the adaptive and robust control problems
Authors: Lagoida A. I.
Published: March 2022

The article analyzes the development of modern approaches for the effective solution of the problems of adaptive and robust control with the compensation of perturbations by the process of drilling of wells during their deepening and accordingly proves that this is a scientific and applied issue, needs proper development, as well as the introduction of new mathematical models of elements. which are the core of the automatic control system. The ways of solving the problem of adaptive and robust control with the standard mathematical model of linear stationary objects by output, which are of great theoretical and applied importance and have been the subject of research in recent years, are considered. The functional structure of the intelligent adaptive ground control system of technical facilities of the hydraulic well-flushing system is developed, which integrates methods of adaptive and robust control, where the adaptive part of the system in the conditions of uncertainty can change the algorithms of operation, structure and parameters of the controller due to additional devices the holes that allow you to adapt to changing working conditions in a timely manner, and the robust system guarantees the required system quality regardless of errors and min parameters of the system because it has a sensitivity remains stable, functioning in a wide range of uncertainty. For the terrestrial elements of the technical hydraulic system for flushing wells, which are considered as objects with concentrated parameters, a phenomenological model is developed, which is based on a holistic approach. The model is formed in the field of Laplace image in time and in dimensionless form as a system of differential equations at zero initial conditions, which accordingly allows to use this model to synthesize the transfer functions of the inverters of local automatic control systems. The methods of control of elements of technical hydraulic system of flushing of wells are offered, based on the use of the developed model and structure of the intelligent system with elements of robust and adaptive control.
ANALYSIS OF METHODS OF INSTALLATION OF TYPICAL TECHNOLOGICAL AND ASSEMBLY SCHEMES OF OBLIGATION OF THE MOUTH OF WELLS PSG ANTI-DISPOSAL EQUIPMENT
Authors: Chernova O. T.
Published: March 2022

Trends in the development of underground gas storage form a series of tasks ahead of science.  One of them is to reduce losses and increase storage. In order to increase the level of safety in all underground gas storage facilities of Ukraine, enterprises and organizations of Ukraine under the obligation to install anti-dumping equipment during the implementation of work on overhaul of wells at the mouth. There are three blocked circuits that are used in the territory of Ukraine.  The main elements of the equipment are installed at the mouth of the well for the entire period of repairs, and additional elements are located on the work platform in the open position and set, depending on the conditions of the work to be performed and the state of the well. Typical drainage schemes of wells of the UGS during the cattle system provide the following operations:  - sealing the mouth of the well in the presence or absence of a drill tool in it; - discharge of the well by gas release through the discharging pipeline;  - replacement of carbonated washing liquid with fresh direct flush with the necessary countermeasures;  - pumping of the washing liquid into the annulus with cement aggregates and drill pumps; - pressure control in the well with a sealed mouth;   - gas withdrawal not less than 100 m from the mouth of the well, and at high density of the location of wells on the PSG and their debits up to 100 thousand m3 / day - not less than 40 m;  - installation of additional equipment or devices for the elimination of gas manifestations and open fountains.
 In the analysis in the work, it was found that typical patterns of obstruction of the wells of PSG during repairs are established taking into account the geological and technical characteristics of the storage, depending on the relationship of reservoir and hydrostatic pressure. The main elements of the equipment are installed at the mouth of the well for the entire period of repairs, additional elements are located on the work platform in the open position and set, depending on the conditions of the work to be performed and the state of the well. For each well, the typical scheme needs to be specified, taking into account the terrain, location of lines of power grids, roads, equipment for repairing wells, auxiliary equipment and other structures and communications.
RELIABILITY AND UNCERTAINTY IN MOBILE CONTROL SYSTEMS
Authors: Lopatin V. V.
Published: March 2022

Mining and oil and gas enterprises (МОGE) of Ukraine operate potentially hazardous equipment of various manufacturers that are on the verge of developing a resource, therefore it is necessary to create methods and means of technological control that comply with regulatory legal acts and industry standards. The most promising means of technological control of МОGE are mobile control systems (MCS). The process of production control by mobile control systems of МОGE is determined by the maximum capabilities inherent in the physical process phenomena that form a specific production control. The author’s point of view is stated that he understands the terms re-refining and non-refining in the MCS and his views on other significant issues of the reliability of control. It is proposed to use the coefficient of variation of the depth of corrosion for a specific mine to increase the reliability of targeted instrumental control of conductors of rigid reinforcement of a mine shaft. The methodology and technology of three-parameter control of MCSs in general are examined in detail. It is proposed to use the Ishikawa diagram to identify causal relationships between factors and consequences in the control problem under study in order to find the optimal solution. An original point of view of technological control is stated and a new approach is proposed for determining the reliability indicators of МОGE control. It is proposed to use the analysis of the budget for the uncertainty of MCSs to improve the control methodology and increase the accuracy of MCSs.
USE OF A ROLLED DEEP NEURAL NETWORK TO DETERMINE THE CHANGE OF THE STRESSED AND DEFORMED STATE OF VERTICAL STEEL CYLINDERAL TANKS BY THE MOVEMENT OF THEIR SURFACE
Authors: Pankiv Yu. V. , Pankiv Kh. V.
Published: March 2022

The main place in determining the mechanical characteristics of the RVS material is occupied by methods and means of VAT control, which include the method of coercive force; magnetic anisotropy method; Barkhausen method, magnetic metal memory (MPM) method, strain gauge method. The advantages of magnetic methods are the ability to control without decommissioning the RVS, safety. The disadvantages inherent in almost all magnetic control methods include the need to prepare the controlled surface, the difficulty of determining the position of the sensors in relation to the maximum loads, the dependence of control results on methods and conditions of measurement, the influence of the air layer between the sensor and the controlled surface.It's shown that to determine the further safe operation possibility of vertical steel cylindrical tank it is necessary to know their stress-strain state. The shortcomings of the existing experimental and mathematical methods of its estimation were highlighted. It's proposed to use a convolutional deep neural network to determine the stress state of a vertical steel cylindrical tank. As input data, it's proposed to use data on the movement of its wall obtained, for example, as a result of geometric calibration at two points in time. The input data was presented in the form of an array of dimensions 8x12, then used convolution and max-pulling. The last layer is fully connected. It's proposed to use cross-entropy as a cost function. To increase the amount of training data, it is proposed to use the values of displacements on stresses obtained by modeling different effects on a cylindrical tank with different shape defects using the SolidWorks package. Possible ways to improve the proposed method are proposed.For further research and improvement of the proposed method, you can try to use other hyper parameters in the neural network, in particular to change the number of feature maps, the size of the local receptive field, the size of the shift step of the receptive field and others.You can also try using the source layer with a different number of neurons and softmax as a function of cost.
IMPROVING THE EFFICIENCY OF THE AUTOMATED SYSTEM OF CONTROL FOR OIL TRANSPORTATION PROCESS ON THE BASIS OF INTELLECTUAL TECHNOLOGIES
Authors: Kuchmistenko O. V.
Published: March 2022

The paper considers an urgent scientific and practical task, which consists in the development of new ones. An urgent scientific and practical task is investigated, which consists in the development of new methods and methods for assessing the technical condition of oil trunk pipelines, which will provide safe automated control of the oil transportation system. It has been determined that in conditions of intensive aging of fixed assets of oil transportation systems and financial constraints, complex technical diagnostics of oil trunk pipelines becomes the most effective means of ensuring the reliability and safety of the entire oil transportation system.

Simulation modeling is inherently complex and time-consuming process that requires many computations, including distributed ones. There are several stages of simulation modeling (MI). In the most general, enlarged form, these are the following stages: setting the problem, collecting and processing data, developing and adjusting the model, modeling, accumulating results, planning experiments, analyzing the results, documenting and storing the results. To carry out such research, various systems for the automation of imitation research (SAIS) are being created. A cloud-based approach to conducting MI, which makes it possible to simplify and unify research for the end user, to abstract the researcher from the technical features of the organization of calculations. Cloud AISI is invariant with respect to the target hardware and software. That is why the development of new and promising control and management tools based on artificial intelligence with a combination of cloud technologies is an urgent scientific and practical task, based on the results of which the main scientific problems requiring further research have been identified.
COMPARATIVE ANALYSIS OF FILTRATION METHODS IN EXPERIMENTAL STUDY OF DYNAMIC PROPERTIES OF OBJECTS
Authors: Gorbilchuk M. I. , Kogutyak M. I. , Borun V. S.
Published: March 2022

The condition for successful application at the local level of control of industrial controllers and programmable logic controllers is the presence of integrated software for automatic tuning of the parameters of the control algorithm. The dynamic properties of an object are most often determined by the results of an active experiment directly on the object through an identification procedure based on pre-processed data.

The main technologies of time series filtering are analyzed and the system of indicators for their comparison is selected. A series of simulation experiments to obtain overclocking characteristics with different degrees of addition of additive barriers to entry and exit are planned and conducted. Simple engineering algorithms of exponential, median, moving average simple and weighted and other window filters are investigated for the efficiency of smoothing in the mode of off-line and on-line processing of the obtained data on the indicators of relative root mean square and integral mean deviation from the baseline. methods.

Based on the results of the research, conclusions are drawn about the real effectiveness of on-line filtering, recommendations for their practical use on the hardware platforms of local controls and the low level of smoothing of off-line methods in a limited experimental sample. The directions of further researches in the direction of application of more difficult filtering algorithms for signals with a high level of interference are established.
The gas-pipelines technical state diagnostics methods diversification in conditions of the natural gas quality estimation system development using the principles of EU
Authors: Maksymjuk S. O. , Karpash O. M.
Published: March 2022

The simulation of the gas supply network in the environment of the graphical interface Matlab - Simulink is carried out in the work, which takes into account the change of parameters of this network at change of qualitative characteristics of energy resource, namely - calorific value of natural gas. The created model showed reduced volumes of natural gas consumption by network consumers in case of improvement of energy quality. The transition of payments for natural gas from volumetric to energy units is normatively supported by international and state legislative documents, the comprehensive coverage of which is given in the paper. This transition of calculations should be accompanied by the development of a system of tools for determining the specific heat of combustion of energy in the flow mode. In the paper it is offered to use this metrological system of means of an estimation of qualitative indicators of an energy resource for the purposes of an additional diagnostic sign of a technical condition of the gas pipeline. Tracking the ranges of changes in the calorific value of natural gas can serve as a basis for assessing changes in the technical condition of the pipeline itself. A diagram of this connection between the technical condition of the pipeline and the quality of the gas flowing through it is given in this paper. Also, to confirm the correlation between the quality of natural gas and the technical condition of the pipeline, the paper presents the results of an experimental study of the possibility of determining the defects of the pipeline by measuring changes in energy quality. The results of this study show that a gas pipeline with corrosion damage is characterized by a significant change in the calorific value of natural gas flowing through it (for the study area "Tustan - Diliyevo" it was 10%).
MAURICE HALBWACHS E A MEMÓRIA COLETIVA E INDIVIDUAL
Authors: Maria Zanezi Peres Sonia
Published: March 2022

Esse artigo tem como objetivo realizar uma abordagem bibliográfica sobre a importância da memória, pois é de suma importância para a formação tanto do sujeito quanto da nação, podendo vim a sofrer alterações, em determinados tempos e espaços, do qual não temos controle físico ou mental assim podendo perpassar fronteiras imaginárias coletivas ou individuais, algumas lembranças solidificam os lugares de memória muito utilizados para justificar ou consolidar a identidade do grupo/sociedade.  A partir da segunda metade do século XX os estudos sobre memória se fortalecem no meio acadêmico principalmente para a disseminação de estudos e pesquisas sobre a temática.
The Aesthetic of Desire and the Feminine Path of Individuation
Authors: Vali-Zadeh Mahdieh
Published: March 2022

Much has been said about the influential role of Forough Farrokhzad (1934–1967) in developing a feminine language in modern Iranian love poetry. Despite this, scholars have not systematically or theoretically examined what I call ‘the poetics of individuation’ in Forough's lyrics. The present article analyses Forough's poetic and individual paths of development as two inevitably parallel and intertwined routes. The article theorises that by removing a pre-imposed patriarchal sense of sin with regard to feminine love, Forough deconstructed the masculine narrative of good poetry in five highly significant ways via the feminine and self gaze. The article concludes that the poet's commitment to poetry as a platform of expression was a means of her liberation and individuation as an independent feminine poet with voice and agency.
Study on Some Effects of Radiofrequency on Human Brain
Authors: Necula E.E , Aciu I.E.
Published: March 2022

The study is based on determining the impact of radiofrequency on humans by taking into account the SAR (Specific Absorption Rate) value and the temperature elevation through the brain. SAR represents a parameter given by each phone manufacturer regarding the amount of radiation emitted and absorbed by the brain. Was used the FlexPDE software to solve the Pennes’ bioheat equation and to determine the temperature elevation in the brain due to radiofrequency. In the graphical output, it was observed a sudden temperature rise above the normal brain one, of 370C, but stabilization after a short period. This study targets to make people aware of both the advantages and disadvantages of GSM usage.
Ein Analyseraster für Traditionskonzeptionen
Authors: Kramm Matthias
Published: March 2022

Tradition is a complex phenomenon of which we can find a multiplicity of conceptualizations in the philosophical, sociological, anthropological, and economic literature. In this paper, I offer both a critical and a constructive contribution to answering the question of how tradition
should be conceptualized. In the critical part, I argue against attempts to construct a unified conception of tradition. In the constructive part, I discuss three taxonomies proposed in the literature and then develop an analytical grid for conceptions of tradition as an alternative. This
analytical grid is based on a sample of 28 accounts of tradition sourced from the contemporary scholarly literature, and makes use of seven dimensions to distinguish among these conceptions.
Factores Psicosociales Intervinientes en el Intento de Suicidio de Adolescentes Paraguayos
Authors: Zavala Manuel
Published: March 2022

El objetivo del presente trabajo fue identificar la relación existente entre algunos factores psicosociales y la ideación suicida en adolescentes paraguayos de 13 a 18 años. El estudio fue de campo, correlacional y transversal. Participaron 59 alumnos de dos institutos de educación media pública y privada, entre el octavo grado y el tercer año de estudios, a quienes se les aplicó la Escala de Sucesos de Vida y un Inventario de Orientaciones Suicidas (IOS). Los resultados muestran que existe una correlación positiva entre la presencia de eventos de ruptura de la estructura familiar e ideación suicida, de la misma manera que con problemas económicos familiares serios, la muerte de alguno de los progenitores, y el sentimiento de soledad experimentada.
Comparative analysis of the range list of medicines for the treatment of arterial hypertension in accordance with domestic and international clinical guidelines
Authors: Шолойко Н. В. , Гончар А. О.
Published: March 2022

Cardiovascular disease is the most common cause of death and disability worldwide. There are more than 12 million patients with hypertension in Ukraine. Timely prescription of medicines patients with AH in accordance with current clinical guidelines significantly improves the quality of life and survival of patients.

The purpose of the study was to conduct a comparative analysis of the international and domestic range of modern medicines for the treatment of hypertension according to INN and ATC-classification and to investigate the status of their registration and inclusion in the reimbursement lists in Ukraine in order to determine the potential physical availability of drugs for the treatment of hypertension.

An analysis of the domestic regulatory framework showed that international CG for the treatment of hypertension and national CPs can be used in Ukraine. The content analysis of the CG showed that international CG include classes of medicines for initial and maintenance therapy of hypertension: ACE inhibitors, ARBs, diuretics (thiazide and thiazide-like), calcium antagonists and beta-blockers, while preference is given to combinations of these drugs due to better adherence patients for treatment.

It was found that according to the ATC classification, 41 ACE inhibitors and their combinations are represented on the international pharmaceutical market for the treatment of hypertension; of which 16 are single-component drugs, 25 are combined; ARB II and their combinations ‒ 32, single-component 10, combinations ‒ 22; calcium channel blockers and their combinations ‒ 21, single-component ‒ 18, combinations ‒ 2, thiazide diuretics ‒ 10, thiazide-like diuretics ‒ 11.

An analysis of the status of registration in Ukraine according to certain INN and ATC classification showed that 56 drugs were registered, which is 48.69% of the possible 115 (drugs and ACE inhibitors and their combinations 22 (53.65%), ARBs II and their combinations 21 (65.63%); CCBs and their combinations ‒ 8 (38.10%); thiazide diuretics ‒ 1 (10%), thiazide-like diuretics ‒ 3 (27.27%)).
Biosimilar insulins in international and domestic practice of pharmacist
Authors: Власенко І. О. , Ніженковська І. В.
Published: March 2022

In Ukraine, people with diabetes receive insulin, including insulin biosimilars in pharmacies, so pharmacists should increase their knowledge about biosimilar because they become more available in the coming years.

The aim of the work was to summarize current information on insulin biosimilars.

Research materials ‒ regulatory database information and scientific publications on biosimilars. Content analysis, bibliosemantic, analytical, generalizing analyzes were used.

The terminology related to reproducible biological drugs (biosimilars) is difference and it depend on the regulatory agency or the country that controls the approve of drugs. Insulin was the first biopharmaceutical drug which was developed. For approving biosimilars, it is necessary to establish similarity with the reference drug in terms of safety, purity and efficacy. Regulatory of biosimilars and requirements for demonstration the biosimilarity are specified in regulatory of the EMA and WHO. The regulatory of the approving of biosimilar  in Ukraine is harmonized with European regulatory. The rules on interchangeability are not determined by all regulatory agency. The International Diabetes Federation emphasizes the role of the pharmacist, stating that they should be well informed about the forms of insulin, includes biosimilars. In Ukraine, pharmacists must dispense insulin, including biosimilars, exactly in accordance to the prescription in which the trade name of insulin (or biosimilars) is indicated. Insulin biosimilars can be an alternative to original insulins that have lost patent protection by increasing the availability of drugs, which can lead to increased market competition and access insulin for patients.

Based on the analysis of current information on biosimilars, generalizations about their terminology, aspects of manufecture, regulatory, interchangeability, prospects in the treatment of diabetes and their replacement of referens insulins are presented. The potential impact of biosimilar insulins to patients and the health care system was determinated. The importance of awareness of these drugs by pharmacists as part of the diabetic team are highlighted.
Training of specialists of Health Technology Assessment: experience of foreign countries
Authors: Білоусова Н. А. , Гетало О. В. , Яковлева О. С.
Published: March 2022

According to the main values of international HTA organizations regarding the development of scientific potential and training of specialists in this field and taking into account the conditions of implementation of medical technology assessment in Ukraine, the scientific interest includes the professional training of HTA users and developers. In this regard, the need of studying the foreign experience and best practices in the use of various curricula, the introduction of forms, methods and technologies is actualized. The author pays special attention to the issue of training these specialists in the system of postgraduate education.

The aim of the article was to analyze the use of modern forms, methods and technologies in vocational education and training of specialists in the assessment of medical technologies.

Materials and methods of the research were strategic programs of EU and Ukraine development, normative and legal documents regulating the implementation of HTA, legislative acts on education development in Ukraine, publications in scientometric databases of Scopus, Web of Science and others.

Research methods used: systematic search of information using search engines, databases and websites by keywords; content analysis of documents; situational and comparative analysis; generalization; prognostication.

According to the results of the analysis of scientific works, the study of international experience revealed that in foreign countries all types of education are used to train specialists in HTA: formal, non-formal, informal. It was found out that the most common forms of obtaining this specialty in the system of formal education are bachelor’s degree, master’s degree, training of doctors of philosophy. At the same time, for the training of such specialists in the middle-income countries, the programs of various duration in the system of non-formal education are used the most often. Among them: courses, trainings, seminars, internships, apprenticeships, mentoring, etc. Certification upon completion of the training is required.

Based on the foreign experience and the analysis of scientific literature, the feasibility of creating and implementing various programs (long-term and short-term, in-service and non-in-service, distance, extramural, full-time, etc.) of the HTA specialists’ training in non-formal education completion of training was proved.