bluuebunny/crossref_metadata_2025 huggingface dataset:
Investigating the Implementation of Process Approach to the Teaching and Learning of Writing Skills: The Case of Ethiopian University
Authors: Zeleke Yitayal Damtew
Published: August 2022

The purpose of this study is to investigate the implementation of process approach to the teaching and learning of writing skills at one of Ethiopian University. The research employed descriptive research design with mixed approach to data gathering and analysis. While qualitative data were analyzed using thematic analysis the quantitative data were analyzed using a descriptive SPSS analysis. The subjects of the study were both 1st year 5 male and 15 female and 2nd year 5 male and 8 female totally 33 undergraduate English as a foreign language students and their 2 writing skills instructors. This was because 1st year undergraduate English as foreign language students take the writing course i.e. Basic Writing Skills and 2nd year undergraduate English as foreign language students take the writing course i.e. Advanced Writing Skills and they were selected by using comprehensive sampling technique. The researchers used classroom observation, questionnaires and semi-structured interview as instruments to collect relevant data. The results of the analysis showed that, instructors did not always focus on the process approach while they deliver the writing lessons and activities; instead they mainly use the product approach in conducting the lessons. There were also factors like, lack of additional material sources, the correction limitation of students’ written works and students’ inability to express themselves’ in the target language that hindered the implementation of the process approach of teaching writing skills.
Exploring Students’ Perception and Use of Movie Clips to Enhance Students’ Participation in English Classroom
Authors: Panjaitan Bontor Rusmida , Hasibuan Monalisa Irmayanti
Published: August 2022

Learning a foreign language is not easy and requires a lot of effort. A teacher must be able to give maximum effort in teaching in the classroom and one way is by using ICT. The aim of this study is to find out whether using movie clips can increase students’ participation in online English classes and what factors caused students to be active in online class. The design of this research is classroom action research (CAR) with the subject of the research was 35 students of class X MIPA 6 at senior high school in Tualang. This research was conducted in one cycle consisting of 5 online class meetings that used movie clips with different genres. From the results of research using observation sheets and interviews with students, it can be seen that students feel more enjoy, enthusiastic, curious in English class so that it affects their activity and participation in class, as most people, basically, like to watch movies. The aim of the interview is to explore students' opinions about what factors are their challenges in online learning. Most students say that they have problems with limited internet quota, unstable internet network, inadequate economy, and even boredom with assignments and deadlines during online learning. In this case the teacher must be able to find alternative solutions for online classes to make students not bored and enjoy the learning environment created by the teacher.
ANALYSIS OF HADITH UNDERSTANDING OF SOCIAL MEDIA PHENOMENA AS A COMMUNICATION TOOL IN THE DIGITAL ERA
Authors: Daffa Muhammad
Published: August 2022

Social interaction is not only done face to face communication but also social interaction can be done online through the sophistication of information technology called social media. The development of social media is becoming a necessity in the 21st century. This research aims to analyze hadith understanding of social media phenomena as a communication tool in the digital era. The formulation of this research problem is how to understand hadith to the phenomenon of social media as a communication tool in the digital era. This study aims to discuss the analysis of hadith understanding of the phenomenon of social media as a means of communication in the digital era. This research is a literature study that focuses research on social media. This research study uses a qualitative approach by applying literature study methods. The formal object of this research is the science of hadith, while the material object is hadith against the phenomenon of social media as a means of communication in the digital era. The results showed that Tirmidhi Hadith Number 2432 contains the importance of good social interaction. Understanding hadith encourages good interaction with social media phenomena. As a means of communication in the digital age, social media has a good and bad influence on social change. This study recommends more in-depth hadith research into the phenomenon of social media.

[Analisis Pemahaman Hadis Terhadap Fenomena Sosial Media sebagai Alat Komunikasi di Era Digital. Interaksi sosial tidak hanya dilakukan secara face to face communication, tapi juga interaksi sosial dapat dilakukan secara online melalui kecanggihan teknologi informasi yang disebut sosial media. Perkembangan penggunaan sosial media menjadi sebuah kebutuhan di abad ke-21. Penelitian ini bertujuan melakukan analisis pemahaman hadis terhadap fenomena sosial media sebagai alat komunikasi di era digital. Rumusan masalah penelitian ini adalah bagaimana pemahaman hadis terhadap fenomena sosial media sebagai alat komunikasi di era digital. Kajian ini bertujuan untuk membahas analisis pemahaman hadis terhadap fenomena sosial media sebagai alat komunikasi di era digital. Penelitian ini merupakan penelitian kepustakaan yang memfokuskan penelitian terhadap sosial media. Kajian penelitian ini menggunakan pendekatan kualitatif dengan menerapkan metode studi literatur. Objek formal penelitian ini adalah ilmu hadis, sedangkan objek materialnya hadis terhadap fenomena sosial media sebagai alat komunikasi di era digital. Hasil penelitian menunjukkan hadis Tirmidzi Nomor 2432 berisi tentang pentingnya interaksi sosial yang baik. Pemahaman hadis mendorong adanya interaksi yang baik terhadap fenomena sosial media. Sebagai alat komunikasi di era digital, media sosial memiliki pengaruh yang baik dan buruk terhadap perubahan sosial. Penelitian ini merekomendasikan penelitian hadis yang lebih mendalam terhadap fenomena media sosial.]
PEOPLES’ HADITH IN DATING HADITH DISCUSSION: Reviewing Another Way to Track the Initial Tradition
Authors: Muna Moh. Nailul
Published: August 2022

This study aims to explain and assess the Peoples' Hadith as part of a historical approach that can be used in Dating Hadith. The criticism of the inauthenticity of the hadith has been widely discussed by skeptical orientalists. The most basic reason for this doubt is that there are no written hadith documents in the era of the Prophet that can be known in the present era. The method they use is the dating of hadith; a method that seeks to find out the source of the earliest hadith documents by determining their age and origin. So far, the dating efforts made by Motzky and Nabia Abbott ended in the 2nd century AH. The difference of a century makes this effort still not sufficient to provide an absolute refutation of orientalist skepticism. Based on the descriptive-analytical method, the author finds that People's Hadith has a novelty in terms of viewpoint in the form of the need to look at document sources in the 1st century AH. through communities outside of Muslims, especially the Bedouin. Due to the widening of the scope of this historical search, the implication that will arise is the discovery of prophetic documents that will be obtained by historians or Islamic scholars with sources that come from the Prophet’s Era in the 7th century AH.

[Ahli Hadis dalam Diskursus Penanggalan Hadis: Meninjau Cara Lain untuk Melacak Tradisi Awal. Kajian ini bertujuan untuk menjelaskan dan menilai Peoples’ Hadith sebagai bagian dari pendekatan sejarah yang dapat digunakan dalam Dating Hadith. Kritik terhadap ketidak-otentikan hadis telah banyak didiskusikan oleh skeptical orientalists. Alasan yang paling mendasar dari keraguan tersebut sebab tidak adanya dokumen hadis tertulis di era Nabi yang bisa diketahui di era sekarang. Metode yang mereka gunakan yakni dating hadith; sebuah metode yang berupaya mencari tahu sumber dokumen hadis paling awal dengan penentuan umur dan asal-muasalnya. Sejauh ini, upaya dating yang dilakukan oleh Motzky dan Nabia Abbott berakhir pada abad ke 2 H. Adanya selisih satu abad menjadikan usaha tersebut masih tidak cukup untuk memberikan sanggahan penolakan yang mutlak atas keskeptisan orientalis. Berdasarkan metode deskriptif-analitis, penulis menemukan bahwa Poeples’ Hadith memiliki kebaharuan dari segi viewpoint berupa perlunya memandang sumber dokumen abad ke 1 H. melalui komunitas-komunitas yang berada di luar muslim, terutama kepada suku Badui. Oleh karena melebarnya ruang lingkup penelusuran sejarah ini, implikasi yang akan muncul yakni adanya penemuan-penemuan dokumen nabi yang akan didapatkan oleh para ahli sejarah atau pengkaji islam dengan sumber yang memang berasal dari Nabi pada abad ke-7 H.]
Is the Revision Rate for Femoral Neck Fracture Lower for Total Hip Arthroplasty Than for Hemiarthroplasty?
Authors: Hoskins Wayne , Corfield Sophia , Lorimer Michelle , Peng Yi , Bingham Roger , Graves Stephen E. , Vince Kelly G.
Published: August 2022

Background:

When arthroplasty is indicated for a femoral neck fracture (FNF), it is unclear whether total hip arthroplasty (THA) or hemiarthroplasty (HA) is best. This study compares data from the Australian Orthopaedic Association National Joint Replacement Registry using contemporary surgical options.

Methods:

Patients from 60 to 85 years old who were treated with arthroplasty for FNF, between September 1999 and December 2019, were included if the femoral stems were cemented. Only THAs with femoral heads of ≥36 mm or dual-mobility articulations were included. Patients who had monoblock HA were excluded. Rates of revision for all aseptic failures and dislocation were compared. Competing risks of revision and death were considered using the cumulative incidence function. Subdistribution hazard ratios (HRs) for revision or death from a Fine-Gray regression model were used to compare THA and HA. Interactions of procedure with age group and sex were considered. Secondary analysis adjusting for body mass index (BMI) and American Society of Anesthesiologists (ASA) classification was also considered.

Results:

There were 4,551 THA and 29,714 HA procedures included. The rate of revision for THA was lower for women from 60 to 69 years old (HR = 0.58 [95% confidence interval (CI), 0.39 to 0.85]) and from 70 to 74 years old (HR = 0.65 [95% CI, 0.43 to 0.98]) compared with HA. However, women from 80 to 85 years old (HR = 1.56 [95% CI, 1.03 to 2.35]) and men from 75 to 79 years old (HR = 1.61 [95% CI, 1.05 to 2.46]) and 80 to 85 years old (HR = 2.73 [95% CI, 1.89 to 3.95]) had an increased rate of revision when THA was undertaken compared with HA. There was no difference in the rate of revision for dislocation between THA and HA for either sex or age categories.

Conclusions:

When contemporary surgical options for FNF are used, there is a benefit with respect to revision outcomes for THA in women who are <75 years old and a benefit for HA in women who are ≥80 years old and men who are ≥75 years old. There is no difference in dislocation rates.

Level of Evidence:

TherapeuticLevel III. See Instructions for Authors for a complete description of levels of evidence.
A Comprehensive Analysis of Energy Efficiency Using Cooperative Spectrum Sensing Network
Authors: Boddukuri Naveen Kumar , Pal Debasish , Bandyopadhyay Ayan Kumar , Koley Chaitali
Published: August 2022

The proposed cooperative spectrum sensing (CSS) network has promising characteristics that might increase detection performance. This study focuses on identifying unknown signals in a Rayleigh fading environment using an improved energy detector (IED). The suggested network is made up of numerous cognitive radio (CR) nodes, with a number of antennas installed at each CR node and selection combining (SC) used to identify the maximum detection probability. Furthermore, the activity of the primary user (PU) is completed at the fusion centre utilizing fusion rules (FC). The closed-form of missing detection and false alarm probability was initially given elegantly. A quantitative evaluation is presented to estimate average throughput and energy efficiency and overall error rate performance is examined for single and multiple antenna situations. Simulation test-bed is developed in MATLAB, and simulations are used to evaluate throughput and energy efficiency performance with the strong backing of mathematical analysis. Finally, when compared to traditional schemes, the performance of the suggested scheme is enhanced, with OR-Rule outperforming AND-Rule.
Establishing the Taxa, Functional profile, and in-silico Ayurvedic Remedy of Microbiota implicated in West Nile Fever
Authors: Bagchi Preenon , Jovita Jemy Ratna , IA Shylesh Murthy
Published: August 2022

West Nile fever causing microbiome is taken in this work. Culex nigripalpus mosquito is the causative factor for West Nile Virus. Using Metatranscriptomic sequencing, identified the taxa and functional profile of the microbiome is identified. Again, the receptor genes involved in West Nile fever is taken and using computer aided drug design, the novel ligands from Ayurvedic medicinal plants Ginkgo biloba, Uncaria tomentosa, Lycoris radiate and Glycyrrhiza glabra. Further, in-vitro and in-vivo studies can be done on the selected ligands to prove their efficiency as drugs for the disease
Phantom and clinical evaluation of a new Bayesian penalized likelihood reconstruction algorithm HYPER Iterative on the image quality of 68Ga-DOTA-NOC PET/CT
Authors: Xu Lei , Cui Can , Li Rushuai , Yang Rui , Liu Rencong , Meng Qingle , Wang Feng
Published: August 2022

Background
Bayesian penalized likelihood (BPL) algorithm is an effective way to suppress the noise by incorporating a smooth penalty in the positron emission tomography (PET) image reconstruction process. The strength of the smooth penalty is controlled by the penalization factor. The aim was to investigate the impact of different penalization factor and acquisition time in a new BPL algorithm HYPER Iterative on the image quality of 68Ga-DOTA-NOC PET/CT. A phantom and 25 patients with neuroendocrine neoplasm underwent 68Ga-DOTA-NOC PET/CT were included. The PET data were acquired with a digital PET/CT in a list-mode and reconstructed by ordered subset expectation maximization (OSEM) and HYPER Iterative algorithm with seven penalization factors between 0.03 and 0.5 for 2 and 3 minutes-per-bed (m/b) acquisition, both including time of flight and point of spread function recovery. The contrast recovery (CR) and background variability (BV) of the phantom, SUVmean and coefficient of variation of liver (CV), and SUVmax of the lesions were measured. Image quality was ranked by two radiologists using the five-point Likert scale.
Results
The CR and BV decreases with the increased of penalization factor for four hot spheres, and HYPER Iterative 2 m/b groups with penalization factor 0.07 to 0.2 had equivalent CR and better BV performance compared to OSEM 3m/b group. The liver SUVmean was approximately equal in all reconstruction groups (range 5.95–5.97), and the liver CVs of HYPER Iterative 2 m/b and 3 m/b groups with the penalization factor of 0.1 to 0.2 were equivalent to OSEM 3 m/b group (p = 0.113–0.711 and p = 0.079–0.287), while the lesions SUVmax significantly increased 19–22% and 25% (all p < 0.001). The highest qualitative score was attained at the penalization factor of 0.2 for HYPER Iterative 2 m/b group (3.20 ± 0.52) and 3 m/b group (3.70 ± 0.36) which was comparable to or greater than OSEM 3m/b group (3.09 ± 0.36, p = 0.388 and p < 0.001).
Conclusions
HYPER Iterative algorithm with penalization factor of 0.2 resulted in higher lesion contrast and lower image noise in comparison with OSEM for 68Ga-DOTA-NOC PET/CT, which allows lower injected activity and shorter acquisition time with preserved image quality.
ECSIT is a critical factor for controlling intestinal homeostasis and tumorigenesis through regulating the translation of YAP protein
Authors: Yang Shuo , Wang Bingwei , Moynagh Paul , Wen Shuang , Liu Lu , Wu Chunyan , Ma Chanyuan , Yang Yongbing , Hu Yingchao , Ma Chunmei , Jiang Yuying
Published: August 2022

The intestinal epithelium is the fastest renewing tissue in mammals and its regenerative process must be tightly controlled to minimize the risk of dysfunction and tumorigenesis. The orderly expression and activation of the YAP protein is a key step in driving intestinal development and crucial for intestinal regenerative responses and homeostasis. However, the regulatory mechanisms controlling this process remain largely unknown. Here, we discovered that evolutionarily conserved signaling intermediate in Toll pathways (ECSIT), a multi-functional protein, was enriched along the crypt-villus axis. And intestinal cell-specific ablation of ECSIT results in the dysregulation of intestinal epithelial cell (IEC) differentiation accompanied with enhanced YAP protein dependent on translation thus transforming intestinal cells to early proliferative stem “-like” cell and augmenting intestinal tumorigenesis. We further revealed that loss of ECSIT impaired mitochondrial metabolism thus reprograming to amino acid-based metabolism, which results in demethylation of genes encoding the eIF4F pathway and their increased expression that further promotes selective YAP translation initiation culminating in intestinal homeostasis imbalance and tumorigenesis. We also show that the expression of ECSIT is positively correlated with the survival of patients with colorectal cancer. Together, our studies demonstrate an important role of ECSIT in maintaining optimal intestinal differentiation homeostasis and controlling the development of tumorigenesis through the regulation of YAP protein translation.
The mechanism of a humid climate on the joints of normal rats and collagen- induced arthritis rats: mutual effects on faecal metabolism and microbial diversity
Authors: Wang Dingnan , Zheng Zhili , Yu Han , Dou Dou , Gao Yining , Xu Shuang , Li Zhiming , Sun Lili , Qiu Xudong , Zhong Xianggen
Published: August 2022

Studies have shown that high humidity is a condition that aggravates the pain of rheumatoid arthritis (RA), but the relevant mechanism is controversial. Currently, there is a lack of animal experimental studies on high humidity as an adverse factor related to the pathogenesis of RA. We used healthy SD rats and collagen-induced arthritis (CIA) rats to investigate the effects of high humidity on arthritis in healthy rats and CIA rats. Integrated metabolomics analyses of faeces and 16S rRNA sequencing of the faecal microbiota were performed to comprehensively analyse the results and diversity of the faecal microbiota and metabolites in healthy rats and CIA rats. In this study, high humidity aggravated arthritis in CIA rats, including articular cartilage lesions, arthritis scores, and proinflammatory cytokines. High humidity had a certain effect on articular cartilage extent, arthritis score and proinflammatory cytokines of healthy rats. Furthermore, high humidity caused significant changes in faecal microbes and faecal metabolites in healthy and CIA rats. Sequencing of the 16S rRNA unit in faecal samples showed that high humidity aggravated inflammation-related bacteria in healthy and CIA rats. Faecal metabolomics results showed that high humidity significantly altered faecal metabolites in healthy rats and CIA rats, and the changes in biological functions were mainly related to the inflammatory response and oxidative stress. Combined analysis showed that there was a strong correlation between the faecal microbiota and faecal metabolites. High humidity is an adverse factor for the onset and development of RA, and its mechanism is related to the inflammatory response and oxidative stress. However, how high humidity leads to the pathogenesis of RA needs to be further determined.
Optimal use of serum leucine-rich alpha-2 glycoprotein as a biomarker for small bowel lesions of Crohn's disease
Authors: Asonuma Kunio , Kobayashi Taku , Kikkawa Nao , Nakano Masaru , Sagami Shintaro , Morikubo Hiromu , Miyatani Yusuke , Hojo Aya , Fukuda Tomohiro , Hibi Toshifumi
Published: August 2022

A large proportion of small bowel lesions in Crohn’s disease (CD) may exist beyond the scope of ileocolonoscopy, suggesting the need for optimal biomarkers. This cross-sectional observational study prospectively measured C-reactive protein (CRP), faecal calprotectin (FC), and leucine-rich alpha-2 glycoprotein (LRG) in patients with quiescent CD who underwent imaging examinations (capsule or balloon-assisted endoscopy, magnetic resonance enterography, or intestinal ultrasound). Mucosal healing (MH) of the small bowel was defined as a lack of ulcers. Patients with a Crohn’s disease activity index of >220 and active colonic lesions were excluded. Seventy patients (29, MH; 41, small bowel inflammation) were analysed. The area under the curve (AUC) of CRP, FC, and LRG was 0.74 (95% confidence interval 0.60-0.86), 0.68 (0.52-0.80), and 0.75 (0.58-0.84), respectively. A cut-off of 16 μg/ml of LRG showed the highest positive predictive value of 0.95 with a specificity of 0.96, while the negative predictive value was the highest (0.71) with a sensitivity of 0.90 at a cut-off of 9 μg/ml. This suggests that LRG can accurately detect and/or exclude the small bowel lesions using two cut-off values.
Evaluation of periodic stability of the oral microbiome from a healthy cohort using 16S ribosomal RNA gene sequencing analysis
Authors: Mangal Utkarsh , Noh Kowoon , Lee Seeyoon , Cha Jae-Kook , Song Je Seon , Cha Jung-Yul , Lee Kee-Joon , Kim Kwang-Mahn , Kwon Jae-Sung , Choi Sung-Hwan
Published: August 2022

ObjectivesThe use of 16S ribosomal RNA gene sequencing analyses has rapidly increased in clinical oral studies. However, cohort-based clinical research has not sufficiently accounted for the periodic stability in oral microbiota. Herein, we aimed to assess the stability of the oral microbiome across time from an intervention-free “healthy” cohort. Materials and MethodsWe obtained 33 supragingival samples of 11 healthy participants from the biobank. For each participant, we processed one sample as baseline (T0) and two samples spaced at monthly (T1) and quarterly (T2) intervals for 16S ribosomal RNA gene sequencing analysis. ResultsWe observed that taxonomic profiling had a similar pattern of dominant genera, namely Rothia, Prevotella, and Hemophilus, at all-time points. Shannon diversity revealed a significant increase from T0 (p<0.05). Bray Curtis dissimilarity was significant (R=-0.02, p<0.01) within the cohort at each time point. Clustering revealed marked differences in the grouping patterns between the three-time points. For all time points, the clusters presented a substantially dissimilar set of differentially abundant taxonomic and functional biomarkers. ConclusionOur observations confirmed presence of periodically different stable states within the oral microbiome in an intervention-free healthy cohort. Accounting for multi-stability will improve the understanding of future research and facilitate identifying and classifying the reliable markers of diseased, healing, healed, and healthy states.Clinical relevanceThe high periodic variation within a healthy cohort demonstrated the presence of multiple stable states within an individual. Clinical research using RNA gene sequencing for comparison should adopt microbiome specific selection criteria for careful classification of a health-associated group.
Small grains from Ryugu: handling and analysis pipeline for Infrared Synchrotron Microspectroscopy
Authors: Rubino Stefano , Dionnet Zélia , Aléon-Toppani Alice , Brunetto Rosario , Nakamura Tomoki , Baklouti Donia , Djouadi Zahia , Lantz Cateline , Mivumbi Obadias , Borondics Ferenc , Lefrançois Stephane , Sandt Christophe , Capitani Francesco , Héripré Eva , Troadec David , Matsumoto Megumi , Amano Kana , Morita Tomoyo , Yurimoto Hisayoshi , Noguchi Takaaki , Okazaki Ryuji , Yabuta Hikaru , Naraoka Hiroshi , Sakamoto Kanako , Tachibana Shogo , Watanabe Seiichiro , Tsuda Yuichi
Published: August 2022

Sample-return missions allow the study of materials collected directly from celestial bodies, unbiased by atmospheric entry effects and/or terrestrial alteration and contamination phenomena, using state-of-the-art techniques which are available only in a laboratory environment - but only if the collected material stays pristine. The scarcity of outer-space unaltered material recovered until now makes this material extremely precious for the potential scientific insight it can bring. To maximize the scientific output of current and future sample-return missions, the scientific community needs to plan for ways of storing, handling, and measuring this precious material while preserving their pristine state for as long as the ‘invasiveness’ of measurements allows. In July 2021, as part of the Hayabusa2 (JAXA) “Stone” preliminary examination team, we received several microscopic particles from the asteroid Ryugu, with the goal of performing IR hyper-spectral imaging and IR micro-tomography studies. Here we describe the sample transfer, handling methods and analytical pipeline we implemented to study this very precious material while minimizing and surveilling their alteration history on Earth.
A parametric approach to estimate streamflow quantiles using annual flow–duration curves
Authors: Asikoglu Omer Levend , Narin Tugce
Published: August 2022

The flow–duration curve (FDC) is a significant instrument used in solving many hydrological and environmental problems such as evaluating water quality, examining water supply and use for hydroelectric generation and irrigation, and investigating sedimentation and low flows. However, the insufficiency of flow data allows FDCs to be used only for gauged basins or gauged locations in a basin. Therefore, obtaining regional relationships that provide effective estimates about a region, by using the records of existing stations in the region, becomes necessary. This paper illustrates a simple parametric approach, where droughts are characterized by using the lower part of the annual flow–duration curve. The paper uses the actual instantaneous flow data of 30 basins in Western Anatolia and 21 basins in Southwestern Anatolia, Turkey to offer a new perspective for the estimation of streamflow quantiles using Areal Scale Factors (ASFs), which efficiently represent the relationship between flow quantile and basin area.
Comparison of purse-string suture versus over-the-scope clip for gastric endoscopic full-thickness closure: traction and leak pressure testing in ex vivo porcine model
Authors: Matsui Takanori , Kobara Hideki , Nishiyama Noriko , Nakatani Kaho , Shi Tingting , Tada Naoya , Kozuka Kazuhiro , Kobayashi Nobuya , Chiyo Taiga , Yachida Tatsuo , Kondo Akihiro , Kishino Takayoshi , Okano Keiichi , Fujihara Shintaro , Uchita Kunihisa , Hirasawa Kingo , Masaki Tsutomu
Published: August 2022

Background The recently developed endoscopic full-thickness resection technique requires reliable closure. The main closure methods are the purse-string suture (PSS) technique and over-the-scope clip (OTSC) technique; however, basic data on the suture strength of each technique are lacking. This study was performed to compare the suture strengths of these two methods in an ex vivo porcine model. Methods In the traction test, a virtual 5-cm full-thickness suture line was closed by the following six methods three times each: conventional hemoclips, mucosal PSS, seromuscular PSS, mucosal OTSC, seromuscular OTSC, and surgical suture. The primary endpoint was the tension at the starting point of dehiscence, measured in Newtons (N) by an automatic traction machine. In the leak test, a 15-mm gastric full-thickness defect was closed by PSS or OTSC six times each, and the sutured stomach was then pressurized in a water container. The primary endpoint was the leak pressure when air bubbles appeared. The secondary endpoints were the procedure time and presence of complete inverted closure.Results The mean tension was 2.16, 3.68, 5.15, 18.30, 19.30, and 62.40 N for conventional hemoclips, mucosal PSS, seromuscular PSS, mucosal OTSC, seromuscular OTSC, and surgical suture, respectively. Complete inverted closure was observed for seromuscular PSS, seromuscular OTSC, and surgical suture. The mean leak pressure was 13.7 and 24.8 mmHg in the PSS and OTSC group, respectively (P < 0.01). The mean procedure time was 541 and 169 seconds in the PSS and OTSC group, respectively (P < 0.01). Complete inverted closure was observed in OTSC alone.Conclusion The OTSC, which allows complete inverted closure, showed greater suture strength than PSS.
Dysphagia lusoria in a young patient with a concomitant aortic arch anomaly, successfully treated with surgery. A case report.
Authors: Endara Santiago A. , Davalos Gerardo A , Cardenas Alberto , Gangotena Karina , Flores Alexis , Molina Gabriel Alejandro
Published: August 2022

BackgroundDysphagia is a relatively common problem in clinical practice, however, an unusual type of dysphagia due to compression of the esophagus by an abnormal right subclavian artery may be discovered in a rare subset of patients. The prognosis and treatment will depend on the severity of the symptoms and the compromise of surrounding structures.Case PresentationWe present the case of an 18-year-old female without past medical history. She suffered a two-month gradually progressive dysphagia accompanied by mild reflux. At first, it was treated as gastroesophageal reflux disease, without result. Dysphagia became severe and additional exams were required. An aberrant right subclavian artery that compressed the esophagus was discovered along with a truncus bicaroticus. She was successfully treated with surgery without any complications. On follow-ups, she's doing well.ConclusionsA symptomatic aberrant right subclavian artery, although rare, should always be corrected after diagnosis to solve symptoms and prevent possible complications. In addition, when necessary, reconstruction of the blood flow to the upper extremity to maintain the arm’s viability and keep the spinal and vertebrobasilar circulation is of paramount importance.
CHL1-deficient and wild-type male mice do not differ in locomotor recovery from spinal cord injury
Authors: Schachner Melitta , Theis Thomas , Ayala Carlos , Tschang Monica , Philip Michele , Nagaraj Vini , Shrirao Anil , Voronin Gregory
Published: August 2022

STUDY DESIGNAnimal studyOBJECTIVESFemale mice deficient in the adhesion molecule CHL1 recovered better than their wild-type female littermates after spinal cord injury (SCI). This observation was unexpected, because CHL1 increases neurite outgrowth in vitro in a homophilic, neuron-dependent manner. Yet, in SCI, CHL1 is upregulated in the glial scar which reduces axonal regrowth, showing that CHL1 on glia can block regrowth of CHL1 positive axons. This notion that was verified in co-cultures of astrocytes and neurons. Since these SCI experiments were confined to females in the previous study, we now sought to assess SCI in CHL1-deficient male mice.SETTINGSW.M. Keck Center for Collaborative Neuroscience at RutgersMETHODSMale CHL1-deficient and wild-type littermate mice received thoracic weight-drop SCI. Locomotor recovery was analyzed weekly by the Basso Mouse Scale and a single frame motion analysis up to six weeks after SCI, when lesion volumes were measured immunohistologically. Hematological analysis was performed at 24 hours after injury.RESULTSCHL1-deficient males did not recover better or worse than their male wild-type littermates. Primary and secondary lesion volumes were similar in the two genotypes under all conditions. In the peripheral blood at 24 h after SCI, leukocyte numbers in mutant males were slightly higher than in wild-type males, but monocyte and lymphocyte numbers did not differ between genders. Neutrophil numbers were higher in males than in females.CONCLUSIONThese results indicate that CHL1-deficient males and females differ in the number of neutrophils slightly in numbers of leukocytes, but not lymphocytes or monocytes.
A hybrid AHP-PROMETHEEII group decision support procedure with decision-makers’ weights assignment: Application in spatial localization
Authors: Omari Youcef , Hamdadou Djamila , Mami Mohammed Amine
Published: August 2022

Organizations and companies are getting increasingly enormous, comprising a significant number of managers and associates from all over the world. This globalization increases the complexity of decisions made within firms, as many decision-makers are engaged, each with their own view of the situation, and a variety of variables impact those judgments. The latter problem is referred to as Multicriteria Group Decision making (MGDM). Decision-makers in MGDM may have varying levels of power within the group; to express this authority, a weight should be assigned to each of them. Due to the impact of these weight values, this process of attributing weights must be held with care. In this paper the authors propose a strategy based on the PROMETHEE II method to handle MGDM problems; in the latter procedure, decision makers' weights are given objectively based on their contribution to the process. The main idea is to employ PROMETHEE II at three different levels: individual rating, weights attribution, and group ranking. The approach was put to the test on a real-world case study in territorial planning. This approach should be enhanced to take into account fuzzy and linguistic numbers, and it should be extended to additional application areas.
Lactate as a major epigenetic carbon source for histone acetylation via nuclear LDH metabolism
Authors: Park Sunghyouk , An Yong Jin , Jo Sihyang , Kim Jin-Mo , Kim Han Sun , Kim Hyun Young , Jeon Sang-Min , Han Dawool , Yook Jong In , Kang Keon Wook
Published: August 2022

Histone acetylation involves the transfer of a two-carbon unit to nucleus as embedded in low-concentration metabolites. We find that lactate, a high-concentration metabolic by-product, can be a major carbon source for histone acetylation, through oxidation-dependent metabolism. Both in cells and in purified nucleus, 13C3-lactate carbons are incorporated into histone H4 (maximum incorporation: ~60%). In purified nucleus, this process depends on nucleus-localized lactate dehydrogenase (LDHA), the knockout of which abrogates the incorporation. Heterologous expression of nucleus-localized LDHA rescues the KO effect. Lactate itself increases histone acetylation, whereas inhibition of LDHA reduces the acetylation. In vitro and in vivo settings exhibit different lactate incorporation patterns, suggesting an influence of the microenvironment. Higher nuclear LDHA localization is observed in pancreatic cancer than in normal tissues, showing the disease relevance. Overall, lactate and nuclear LDHA can be major structural and regulatory players in the metabolism-epigenetics axis controlled by cell’s own or environmental status.
Erosion Source Area Identification Using Rusle and Multi-criteria Decision Analysis, Acase of Andassa Watershed, Upper Blue Nile Basin
Authors: Tegegne Moges Animut , Zewudu Yibeltal , Fentahun Tadele
Published: August 2022

The Main objective of this study was to identify source areas of soil erosion and quantify rate of soil erosion and sediment yield in Andassa watershed, Blue Nile Basin. In this study, Multi Criteria Decision analysis (MCDA) technique integrated with GIS and Remote sensing was applied to estimate soil erosion source areas, identify major soil erosion factor (s), prioritize and map the most sensitive soil erosion sources of the watershed for soil and water conservation practice. From soil erosion factors, Topographic wetness index followed by land use land cover have been found to have significant effect on soil erosion in the watershed. The result shows in qualitative Sensitivity map investigates that the more than half of the watershed was under moderately sensitive risk of soil erosion (68.12%) about 400.861km2. Next 17.56% (103.35km2) of the watershed was under slightly sensitive and the remaining 14.27% (83.999 km2) of the watershed was under highly sensitive risk of soil erosions. From the overall combined map of Multicriteria decision analysis (MCDA) map showing the areas of increased risk erosion represented by highly sensitive (S1), moderately sensitive(S2), less sensitive(S3), and constraint areas so the governmental or non-governmental organizations or any concerned organization should refer this important severity map of soil erosion for watershed management and priority of the watershed. Even though measured values of sediment yield at the catchment are hardly available the hotspot areas can be identified by multicriteria decision analysis and significant amount of soil loses are sourced from Gully sites.
Association of FGF10 polymorphism of rs339501 with myopia: A systematic review and meta-analysis
Authors: Hou Peixian , Yang Guoyuan , Chen Pengfan , Wang Guiqu , Liu Longqian
Published: August 2022

Purpose: To carry out a meta-analysis of potential genetic association studies in order to determine whether the FGF10 polymorphism rs339501 is related to myopia. Method: All the eligible case control studies examing the association of FGF10 polymorphisms and myopia published up to 20 January 2022 were retrieved from MEDLINE, Embase, the Cochrane library, Web of Science, the China National Knowledge Infrastructure (CNKI) and the VIP database of Chinese periodicals without language restriction. Depending on the heterogeneity among studies, a fixed-effect model or a random-effect model was chosen to compute the 95% confidence intervals (95%CIs) and odds ratios (ORs) for single nucleotide polymorphism (SNP). Publication bias were analyzed by examining the symmetry of the funnel plots and further confirmed by Begg’s and Egger’s tests. Stability of the analyses was checked by the sensitivity analysis.Results：6 studies were finally included in our analysis. The subgroup analyses focusing on Chinese population found some significant results, which mainly fell on the recessive model and homozygote model(p<0.05), especially for the high myopia, of whom the pooled results in allelic model and dominant model(p＜0.05) were also significant. Additionally, the allelic model(p＜0.05) for the correlation between SNP rs339501 and myopia was also significant in Chinese population. Unfortunately, our analysis for the overall population did not reach a statistically significant result.Conclusion: G allele of SNP rs339501 would increase the risk of myopia for Chinese population. Large-scale researches are still needed to corroborate the associations.
Conjugated polymer-functionalized perovskite semiconductors for electrolyte-gated transistors
Authors: Nketia-Yawson Vivian , Nketia-Yawson Benjamin , Opoku Henry , Lee Ji Hyeon , Jo Jea Woong
Published: August 2022

In emerging perovskite transistors, interfacial engineering is pivotal for modulating the effective charge carrier transport; however, gate dielectric layer and its interface remain unexplored owing to the limited chemical stability of perovskites. Here, we propose an interfacial functionalization with a conjugated polymer to allow the use of high capacitance electrolyte dielectric in top-gate perovskite transistors. This multifunctional approach, exploiting orthogonal solution-processed polymers, enables blocking of chemical diffusion during the deposition of the dielectric, allows passivation of defects on the perovskite surface, results in air stability enhancement, and boosts mobility via the formation perovskite-polymer hybrid channels. The optimized conjugated polymer-capped lead iodide perovskite transistors showed a remarkable hole mobility of over 30 cm2 V–1 s–1 at ≤ 2 V. This result demonstrated the possibility of realizing high mobility through interfacial functionalization of perovskites in transistor applications.
Fine Particulate Matter Exposure and Inhalation Dose during Traffic Commuting-A Case Study in Guangzhou
Authors: Li Zhisheng , Zeng Jiangyi , Wu Mengting , Jin Yukai , Wang Xiaoxia , Zhai Shuya
Published: August 2022

This research focuses on the PM exposure of commuters under five modes of transportation (subway, bus, bicycle, automobile and walking) in Haizhu District, Guangzhou. By portable aerosol Monitor (Grimm spectrometer, Model 11-R) with a time resolution of 6 seconds, the real-time exposure concentration, the average exposure concentration and inhalation dose of commuters were analyzed. The length of route is designed as a 60-minute walking distance, about 4 kilometers. The average PM2.5 exposure concentration of different commuting modes was 29.77 ± 6.33µg/m³, 22.98 ± 3.13µg/m³, 35.50 ± 7.14µg/m³, 28.65 ± 4.12µg/m³, 10.75 ± 1.04µg/m³ and 47.29 ± 14.24µg/m³, corresponding to subway, bus, bicycle, car(windows closed), car(windows open) and walking respectively. During peak hours, commuters who take subway, bus and car can better avoid exposure to particulate pollution, especially in the evening rush hour. The opening or closing of the window is a critical factor affecting the exposure concentration of pollutants in the car. The inhalation dose of PM2.5 was 1.057 ± 0.003µg, 1.654 ± 0.002µg, 21.088 ± 0.021µg, 1.722 ± 0.003µg, 0.601 ± 0.001µg, and 31.723 ± 0.018µg, corresponding to subway, bus, bicycle, car(windows closed), car(windows open) and walking. According to the research, sub-micron particles (PM1.0) are the main particles in subway and the opening, and in the compartment, closing of compartment doors causes an instantaneous spike in the concentration of particulate matter .
Comparison of Fetal Heart Rate Baseline Estimation by the Cardiotocograph Network and Clinicians: A Multidatabase Retrospective Assessment Study
Authors: Pan Xiuyu , Lu Yaosheng , Zhong Mei , Wang Huijin , Zheng Zheng , Bai Jieyun
Published: August 2022

Objective
This study aims to compare the fetal heart rate (FHR) baseline predicted by the cardiotocograph network (CTGNet) with that estimated by clinicians.
Results
A total of 1267 FHR recordings acquired with different electrical fetal monitors (EFM) were collected from five datasets. Each FHR baseline was estimated by clinicians and CTGNet, respectively. And agreement between CTGNet and clinicians was evaluated using the kappa statistics, intra-class correlation coefficient, and the limits of agreement. The number of differences < 3 beats per minute (bpm), 3–5 bpm, 5–10 bpm and ≥ 10 bpm, is 64.88%, 15.94%, 14.44% and 4.74%, respectively. Kappa statistics and intra-class correlation coefficient are 0.873 and 0.969, respectively. Limits of agreement are − 6.81 and 7.48 (mean difference: 0.36 and standard deviation: 3.64). An excellent agreement was found between CTGNet and clinicians in the baseline estimation from FHR recordings with different signal loss rates.
Relationship between glycemic variability and arrhythmias: protocol for a systematic review and meta-analysis
Authors: Li zinan , Yang Jiao , Qiu Xianliang , Zhou Qian , Fu Shunlian , Chen Qiu
Published: August 2022

Introduction
Arrhythmias are common in type 2 diabetic patients. The link between blood glucose fluctuations and arrhythmia risk is gaining attention.TThe aim of this systematic review is to investigate the relationship between blood glucose variability and arrhythmia in patients with T2DM and provide more advanced evidence for clinical practice.
Methods and analysis
PubMed, EMBASE, The Cochrane Library, China Biology Medicine disc, and the Wanfang database online will be included to be searched.We'll look for publications, conference papers, current trials, and internal reports, as well as observational research, by hand (cross-sectional and follow-up studies) written in English or Chinese examining the relationship between abnormal glycemic variability and arrhythmias in patients with T2DM up to 30 June 2021.The articles will be read independently by two reviewers. Information such as first author, time of publication and outcome measures will be extracted. Researchers will also assess the quality of the literature using the Cochrane Handbook's quality assessment criteria. RevMan 5.3.5, EndNote X7, and STATA 13.0 will be utilized for data analysis.We will use extractable data for systematic evaluation at last.
Ethics and dissemination:
Because this systematic review used published data, no ethical approval was necessary.
Physics of sliding on water predicts morphological and behavioral allometry in water striders
Authors: Kim Woojoo , Lee Jae Hong , Pham Thai , Tran Anh , Ha Jungmoon , Bang Sang Yun , Jablonski Piotr , Kim Ho-Young , Lee Sang-im
Published: August 2022

Water striders, Gerridae, serve as model organisms to understand locomotion on the water surface, but only a narrow range of body sizes have been studied. The hydrodynamics of their thrust is well understood, but the subsequent sliding dynamics has been less explored. Here we create a theoretical model of sliding and use it to predict the effect of body mass, striding gait (symmetrical or asymmetrical) and wetted leg lengths on the striders’ ability to float and the resistance during sliding. We show that the water strider species with large body size have two alternative solutions: development of long forelegs that support frontal body during symmetrical striding or asymmetrical striding when one midleg extends forward to support the frontal body. The model lays the theoretical grounds for the future comparative analyses of adaptive allometry in locomotion of Gerridae, and for bioinspired water walking devices of a wide size range.