bluuebunny/crossref_metadata_2025 huggingface dataset:
Screening for oncogenic AF1q expression predicts disease recurrence in gastric cancer patients
Authors: Gruber Elisabeth S. , Oberhuber Georg , Schlederer Michaela , Birner Peter , Jomrich Gerd , Schoppmann Sebastian F. , Tse William , Kenner Lukas
Published: July 2024

AF1q associates with tumor progression and metastases upon WNT signaling. The downstream WNT target CD44 has demonstrated prognostic significance in gastric cancer (GC). This study evaluates the impact of AF1q on tumor stage and survival in GC patients. Immunohistochemical marker expression was analyzed and data were processed to correlation and survival analysis. Out of 182 GC samples, 178 (97.8%) showed moderate to high AF1q expression (p < 0.001), these samples correlated with positive lymph node stage (p = 0.036). In a subgroup analysis of patients with nodal-positive GC (n = 129, 70.9%), enhanced tumoral AF1q expression resulted in impaired recurrence-free survival (RFS, p = 0.030). Enhanced tumoral CD44 expression resulted in impaired disease-specific survival (DSS) in the subgroup of patients with nodal-positive GC (p = 0.031) as well as in the overall GC group (p = 0.005). AF1q demonstrated as an independent prognostic marker for RFS (p = 0.035) and CD44 for DSS (p = 0.036). AF1q has shown potential for prognostication of RFS in GC patients and is predominantly expressed in nodal-positive GC. Testing AF1q provides a possibility of identifying patients with locoregional (and advanced) disease, particularly at risk for disease recurrence. Implementing AF1q into the diagnostic process may facilitate screening, prognosis estimation as well as consideration of preoperative multimodal treatment in patients qualifying for elective upfront surgery.
Bisphenol S causes excessive estrogen synthesis by activating FSHR and the downstream cAMP/PKA signaling pathway
Authors: Zhang Xiaorong , Zhang Xinda , Zhang Zhenzhong , Shi Yijiao , Wang Jun , Ru Shaoguo , Tian Hua
Published: July 2024

Estrogen excess in females has been linked to a diverse array of chronic and acute diseases. Emerging research shows that exposure to estrogen-like compounds such as bisphenol S leads to increases in 17β-estradiol levels, but the mechanism of action is unclear. The aim of this study was to reveal the underlying signaling pathway-mediated mechanisms, target site and target molecule of action of bisphenol S causing excessive estrogen synthesis. Human ovarian granulosa cells SVOG were exposed to bisphenol S at environmentally relevant concentrations (1 μg/L, 10 μg/L, and 100 μg/L) for 48 h. The results confirms that bisphenol S accumulates mainly on the cell membrane, binds to follicle stimulating hormone receptor (FSHR) located on the cell membrane, and subsequently activates the downstream cyclic adenosine monophosphate/protein kinase A (cAMP/PKA) signaling pathway, leading to enhanced conversion of testosterone to 17β-estradiol. This study deepens our knowledge of the mechanisms of environmental factors in pathogenesis of hyperestrogenism.
Transcriptome and metabolome analyses reveal regulatory networks associated with nutrition synthesis in sorghum seeds
Authors: Khan Adil , Tian Ran , Bean Scott R. , Yerka Melinda , Jiao Yinping
Published: July 2024

Cereal seeds are vital for food, feed, and agricultural sustainability because they store and provide essential nutrients to human and animal food and feed systems. Unraveling molecular processes in seed development is crucial for enhancing cereal grain yield and quality. We analyze spatiotemporal transcriptome and metabolome profiles during sorghum seed development in the inbred line ‘BTx623’. Morphological and molecular analyses identify the key stages of seed maturation, specifying starch biosynthesis onset at 5 days post-anthesis (dpa) and protein at 10 dpa. Transcriptome profiling from 1 to 25 dpa reveal dynamic gene expression pathways, shifting from cellular growth and embryo development (1–5 dpa) to cell division, fatty acid biosynthesis (5–25 dpa), and seed storage compounds synthesis in the endosperm (5–25 dpa). Network analysis identifies 361 and 207 hub genes linked to starch and protein synthesis in the endosperm, respectively, which will help breeders enhance sorghum grain quality. The availability of this data in the sorghum reference genome line establishes a baseline for future studies as new pangenomes emerge, which will consider copy number and presence-absence variation in functional food traits.
Glutathione determines chronic myeloid leukemia vulnerability to an inhibitor of CMPK and TMPK
Authors: Huang Chang-Yu , Chung Yin-Hsuan , Wu Sheng-Yang , Wang Hsin-Yen , Lin Chih-Yu , Yang Tsung-Jung , Fang Jim-Min , Hu Chun-Mei , Chang Zee-Fen
Published: July 2024

Bcr-Abl transformation leads to chronic myeloid leukemia (CML). The acquirement of T315I mutation causes tyrosine kinase inhibitors (TKI) resistance. This study develops a compound, JMF4073, inhibiting thymidylate (TMP) and cytidylate (CMP) kinases, aiming for a new therapy against TKI-resistant CML. In vitro and in vivo treatment of JMF4073 eliminates WT-Bcr-Abl-32D CML cells. However, T315I-Bcr-Abl-32D cells are less vulnerable to JMF4073. Evidence is presented that ATF4-mediated upregulation of GSH causes T315I-Bcr-Abl-32D cells to be less sensitive to JMF4073. Reducing GSH biosynthesis generates replication stress in T315I-Bcr-Abl-32D cells that require dTTP/dCTP synthesis for survival, thus enabling JMF4073 susceptibility. It further shows that the levels of ATF4 and GSH in several human CML blast-crisis cell lines are inversely correlated with JMF4073 sensitivity, and the combinatory treatment of JMF4073 with GSH reducing agent leads to synthetic lethality in these CML blast-crisis lines. Altogether, the investigation indicates an alternative option in CML therapy.
Engineering phase competition between stripe order and superconductivity in La1.88Sr0.12CuO4
Authors: Küspert J. , Biało I. , Frison R. , Morawietz A. , Martinelli L. , Choi J. , Bucher D. , Ivashko O. , v Zimmermann M. , Christensen N. B. , Mazzone D. G. , Simutis G. , Turrini A. A. , Thomarat L. , Tam D. W. , Janoschek M. , Kurosawa T. , Momono N. , Oda M. , Wang Qisi , Chang J.
Published: July 2024

Unconventional superconductivity often couples to other electronic orders in a cooperative or competing fashion. Identifying external stimuli that tune between these two limits is of fundamental interest. Here, we show that strain perpendicular to the copper-oxide planes couples directly to the competing interaction between charge stripe order and superconductivity in La1.88Sr0.12CuO4 (LSCO). Compressive c-axis pressure amplifies stripe order within the superconducting state, while having no impact on the normal state. By contrast, strain dramatically diminishes the magnetic field enhancement of stripe order in the superconducting state. These results suggest that c-axis strain acts as tuning parameter of the competing interaction between charge stripe order and superconductivity. This interpretation implies a uniaxial pressure-induced ground state in which the competition between charge order and superconductivity is reduced.
Constraining ultralight dark matter through an accelerated resonant search
Authors: Xu Zitong , Ma Xiaolin , Wei Kai , He Yuxuan , Heng Xing , Huang Xiaofei , Ai Tengyu , Liao Jian , Ji Wei , Liu Jia , Wang Xiao-Ping , Budker Dmitry
Published: July 2024

Typical weak signal search experiments rely on resonant effects, where the resonance frequency is scanned over a broad range, resulting in significant time consumption. In this study, we demonstrate an accelerated strategy that surpasses the typical resonance-bandwidth limited scan step without compromising sensitivity. We apply this method to an alkali-noble-gas spin system, achieving an approximately 30-fold increase in scanning step size. Additionally, we obtain an ultrahigh sensitivity of 1.29 fT ⋅ Hz−1/2 at around 5 Hz, corresponding to an energy resolution of approximately 1.8 × 10−23eV ⋅ Hz−1/2, which is among the highest quantum energy resolutions reported. Furthermore, we use this sensor to search for axion-like particles, setting stringent constraints on axion-like particles (ALPs) in the 4.5–15.5 Hz Compton-frequency range coupling to neutrons and protons, improving on previous limits by several-fold. This accelerated strategy has potential applications in other resonant search experiments.
Blood protein assessment of leading incident diseases and mortality in the UK Biobank
Authors: Gadd Danni A. , Hillary Robert F. , Kuncheva Zhana , Mangelis Tasos , Cheng Yipeng , Dissanayake Manju , Admanit Romi , Gagnon Jake , Lin Tinchi , Ferber Kyle L. , Runz Heiko ,   Biogen Biobank Team, Ferber Kyle L. , Foley Christopher N. , Marioni Riccardo E. , Sun Benjamin B.
Published: July 2024

The circulating proteome offers insights into the biological pathways that underlie disease. Here, we test relationships between 1,468 Olink protein levels and the incidence of 23 age-related diseases and mortality in the UK Biobank (n = 47,600). We report 3,209 associations between 963 protein levels and 21 incident outcomes. Next, protein-based scores (ProteinScores) are developed using penalized Cox regression. When applied to test sets, six ProteinScores improve the area under the curve estimates for the 10-year onset of incident outcomes beyond age, sex and a comprehensive set of 24 lifestyle factors, clinically relevant biomarkers and physical measures. Furthermore, the ProteinScore for type 2 diabetes outperforms a polygenic risk score and HbA1c—a clinical marker used to monitor and diagnose type 2 diabetes. The performance of scores using metabolomic and proteomic features is also compared. These data characterize early proteomic contributions to major age-related diseases, demonstrating the value of the plasma proteome for risk stratification.
Using large language models to assess public perceptions around glucagon-like peptide-1 receptor agonists on social media
Authors: Somani Sulaiman , Jain Sneha S. , Sarraju Ashish , Sandhu Alexander T. , Hernandez-Boussard Tina , Rodriguez Fatima
Published: July 2024

Background

The prevalence of obesity has been increasing worldwide, with substantial implications for public health. Obesity is independently associated with cardiovascular morbidity and mortality and is estimated to cost the health system over $200 billion dollars annually. Glucagon-like peptide-1 receptor agonists (GLP-1 RAs) have emerged as a practice-changing therapy for weight loss and cardiovascular risk reduction independent of diabetes.

Methods

We used large language models to augment our previously reported artificial intelligence-enabled topic modeling pipeline to analyze over 390,000 unique GLP-1 RA-related Reddit discussions.

Results

We find high interest around GLP-1 RAs, with a total of 168 topics and 33 groups focused on the GLP-1 RA experience with weight loss, comparison of side effects between differing GLP-1 RAs and alternate therapies, issues with GLP-1 RA access and supply, and the positive psychological benefits of GLP-1 RAs and associated weight loss. Notably, public sentiment in these discussions was mostly neutral-to-positive.

Conclusions

These findings have important implications for monitoring new side effects not captured in randomized control trials and understanding the public health challenge of drug shortages.
EXPAR for biosensing: recent developments and applications
Authors: Ou Xinyi , Li Kunxiang , Liu Miao , Song Jiajun , Zuo Zhihua , Guo Yongcan
Published: July 2024

Schematic illustration of EXPAR-based biosensing techniques.
Proteomic and phosphoproteomic profiling of urinary small extracellular vesicles in hepatocellular carcinoma
Authors: Li Dejun , Gao Yujun , Wang Chong , Hu Lianghai
Published: July 2024

Proteomic and phosphoproteomic landscape of urinary small extracellular vesicles in patients with hepatocellular carcinoma were achieved by mass spectrometry.
Thiolated polyglycerol sulfate as potential mucolytic for muco-obstructive lung diseases
Authors: Arenhoevel Justin , Kuppe Aditi , Addante Annalisa , Wei Ling-Fang , Boback Nico , Butnarasu Cosmin , Zhong Yinan , Wong Christine , Graeber Simon Y. , Duerr Julia , Gradzielski Michael , Lauster Daniel , Mall Marcus A. , Haag Rainer
Published: July 2024

Sputum of cystic fibrosis patients shows increased viscoelastic properties due to disulfide crosslinking. Treatment with the mucolytic polymer dPGS-SH reduces disulfide crosslinks, leading to decreased viscoelasticity in sputum samples.
A chitosan-based hydrogel loaded with fenofibrate for diabetic wound healing
Authors: Wang Miaofeng , Deng Yaping , Huang Cancan , Javeed Ansar , Wang Yifan , Han Bingnan , Jiang Guojun
Published: July 2024

Diabetic wounds represent a common chronic condition, posing significant challenges in the treatment process due to bacterial infections, increased generation of reactive oxygen species (ROS) and exacerbated inflammation.
A neutral crystalline imino-substituted silyl radical
Authors: Kiefer Fiona J. , Kostenko Arseni , Holzner Richard , Inoue Shigeyoshi
Published: July 2024

The neutral three-coordinated imino(silyl)silyl radical was isolated from the reaction of ItBuN-SiBr3 with NaSitBu2Me. The radical was fully characterized by SC-XRD and EPR spectroscopy and supported by quantum chemical calculations.
Evaluation of halogen bonding proclivity of oxazole derivatives carrying multiple acceptor sites in cocrystals with perfluorinated iodobenzenes
Authors: Sušanj Ruđer , Bedeković Nikola , Cerovski Sara , Baus Topić Nea , Nemec Vinko , Cinčić Dominik
Published: July 2024

Novel halogen-bonded cocrystals of seven oxazoles as multifunctional acceptors have been synthesized with selected iodoperfluorinated benzenes and structurally characterized.
Description of an original molecular ordering process into a disordered crystalline form: the atypical low-temperature transformation of the disordered form III of linezolid
Authors: Khalaji Mehrnaz , Dudek Marta Katarzyna , Paccou Laurent , Danède Florence , Guinet Yannick , Hédoux Alain
Published: July 2024

Ordering process into a disordered distribution of frozen molecular conformations via continuous transformation mixing displacive and order–disorder signatures.
Photoelectron spectra of functionalized adamantanes
Authors: Crandall Parker , Stahl Simone , Merli Andrea , Förstel Marko , Dopfer Otto
Published: July 2024

Photoelectron spectra of adamantane derivatives analysed by sophisticated density functional theory calculations unravel the effects of functional groups and modification of the hydrocarbon cage on their geometric, vibrational and electronic structure.
Role of the catalyst structure–activity relationship in enhancing the selective oxidation yield of n-butane to maleic anhydride
Authors: Faizan Muhammad , Aamir Erum , Kiong Tiong Sieh , Song Hua
Published: July 2024

Vanadium phosphorus oxide (VPO) catalysts are synthesized for utilization of lighter alkanes such as n-butane to produce maleic anhydride (MA) by a selective oxidation process.
Sulfate-modified iron oxide catalyzed epoxidation of styrene with CO2 activated hydrogen peroxide in water
Authors: Wang Fangchao , Yang Wei , Ding Ding , Cui Hongyi , Zhang Guoying
Published: July 2024

A practical sulfate-modified iron oxide catalytic system promoting the epoxidation of styrene using hydrogen peroxide as the oxidant in a solvent-free environment was developed. The key reactive oxygen species 1O2 was trapped and detected.
Catalytic activity of Cu–cysteine coated on Ti3C2MXene toward peroxymonosulfate activation for carbamazepine degradation
Authors: Sanga Pascaline , Saad Al-mashriqi Haitham , Xiao Jing , Chen Jia , Qiu Hongdeng
Published: July 2024

Cu–cy/Ti3C2MXene demonstrated outstanding catalytic performance in activating peroxymonosulfate, leading to the production of reactive oxygen species that decomposed up to 98.6% of carbamazepine.
Synthesis of N-doped porous carbon derived from biomass waste for activating peroxymonosulfate in water decontamination: mechanism insight and biotoxicity assessment
Authors: Ding Shun , Fu Fangyu , Niu Huibin , Yan Jiaying , Fang Yanfen , Liu Xiang
Published: July 2024

Herein, a series of N-doped carbon nanomaterials were synthesized by the pyrolysis of biomass waste and various nitrogen sources for sulfamethoxazole degradation via peroxymonosulfate activation.
Optical materials discovery and design with federated databases and machine learning
Authors: Trinquet Victor , Evans Matthew L. , Hargreaves Cameron J. , De Breuck Pierre-Paul , Rignanese Gian-Marco
Published: July 2024

New hypothetical compounds are reported in a collection of online databases. By combining active learning with density-functional theory calculations, this work screens through such databases for materials with optical applications.
Seeing nanoscale electrocatalytic reactions at individual MoS2 particles under an optical microscope: probing sub-mM oxygen reduction reaction
Authors: Afsahi Nikan , Zhang Zhu , Faez Sanli , Noël Jean-Marc , Panda Manas Ranjan , Majumder Mainak , Naseri Naimeh , Lemineur Jean-François , Kanoufi Frédéric
Published: July 2024

Interferometric scattering microscopy (iSCAT) allows visualizing individual petal-like MoS2 sub-microparticles and monitoring operando their activity towards oxygen reduction reaction.
Unraveling the thermal stability of aromatic disulfide epoxy vitrimers: a comprehensive study using principal component analysis (PCA)
Authors: Fanlo Paula , Ruiz de Luzuriaga Alaitz , Albizu Gorka , Ximenis Marta , Rekondo Alaitz , Grande Hans Jürgen , Sardon Haritz
Published: July 2024

This study combines 1H NMR and chemometrics to determine optimal processing conditions for aromatic disulfide-based vitrimers, revealing a correlation between model reactions and vitrimer networks.
Recent advancements in metal organic framework-modified multifunctional materials for photodynamic therapy
Authors: Pattnaik Archana Kumari , Priyadarshini Newmoon , Priyadarshini Priyanka , Behera Gobinda Chandra , Parida Kulamani
Published: July 2024

MOFs modified functional materials have emerged in the therapeutic platform, PDT in particular, implementing various paths and mechanisms to hit the target cells, unveiling a substantial direction for cancer therapy.
Synthesis, characterization, and application of a biocompatible gene delivery nanocarrier constructed from gold nanostars and a chitosan–cyclodextrin–poly(ethylene imine) graft polymer
Authors: Tabesh Farbod , Haghverdi Golnaz , Devarakonda Kireeti Phani , Massoud Tarik F , Paulmurugan Ramasamy
Published: July 2024

Synthesis of biocompatible nanocomposite with AuNS, CS and bPEI as a universal non-viral gene delivery nanocarrier for targeted delivery of therapeutic RNA and DNA to cells.
Identification of autophagy-related signatures in nonalcoholic fatty liver disease and correlation with non-parenchymal cells of the liver
Authors: Chen Kaiwei , Wei Ling , Yu Shengnan , He Ningning , Zhang Fengjuan
Published: July 2024

Our study identified 6 autophagy-related hub genes in NAFLD and validated them using animal models and patient tissue sections. FOS, MYC, CCL2, and PPP1R15A could be potential biomarkers for autophagy in NAFLD and may be targets for gene therapy.
Finite element modeling of plasmonic resonances in photothermal gold nanoparticles embedded in cells
Authors: París Ogáyar Marina , López-Méndez Rosalía , Figueruelo-Campanero Ignacio , Muñoz-Ortiz Tamara , Wilhelm Claire , Jaque Daniel , Espinosa Ana , Serrano Aida
Published: July 2024

The plasmonic response of Au nanospheres (NSs) in MCF-7 cells is investigated comparing experimental data with 3D simulations. Our findings highlight the impact of NS assembly, the surrounding medium, and interparticle gap on photothermal efficiency.
Excited state dynamics of homoleptic Zn(ii)dipyrrin complexes and their application in photocatalysis
Authors: Leier Julia , Rauthe Pascal , Tabone Roberta , Bizzarri Claudia , Unterreiner Andreas-Neil
Published: July 2024

Using Zn-dipyrrins as photocatalysts involves exciting an intramolecular charge-transfer (ICT) state and intersystem crossing (ISC). To optimize the catalyst, studying ISC branching pathways competing with fluorescence and internal conversion (IC) is essential.
Asymmetric synthesis of 1H-pyrazolo[3,4-b]pyridine analogues catalyzed by chiral-at-metal Rh(iii) complexes
Authors: Ji Xiang , Zhu Shijie , Li Yongsheng , Zhao Zhifei , Li Shi-Wu
Published: July 2024

An efficient asymmetric Friedel–Crafts-type alkylation/cyclization of 5-aminopyrazoles has been developed, affording corresponding pyrazolo[3,4-b]pyridine analogues.
Total synthesis of (–)-deglycocadambine
Authors: Wang Fang-Xin , Chen Ying-Tao , Liu Hui , Wang Heng-Shan , Liang Hong , Chen Zhen-Feng , Chi Yonggui Robin
Published: July 2024

The first total synthesis of (–)-deglycocadambine is achieved from (+)-genipin, wherein the well-designed cascade annulation and the late-stage transannular oxidative cyclization clearly unveil the bond-forming logic in this synthetic route.
Lipase-catalysed esterification in a reactive natural deep eutectic solvent leads to lauroylcholine chloride rather than glucose ester
Authors: Buzatu Alina Ramona , Soler Miguel Angel , Ozkilinc Ozge , Fortuna Sara , Dreavă Diana Maria , Bîtcan Ioan , Giannozzi Paolo , Fogolari Federico , Gardossi Lucia , Peter Francisc , Todea Anamaria , Boeriu Carmen Gabriela
Published: July 2024

Lauroylcholine chloride is the product of lipase catalysed esterification of a choline chloride/glucose/water (2 : 1 : 1) reactive natural deep eutectic solvent (R-NADES).
Unveiling the dual-function applications of a magnetically retrievable chemically grafted Schiff base Cu-complex on graphene oxide for catalytic and antibacterial applications
Authors: Gogoi Himadri Priya , Goswami Nilotpal , Barman Pranjit
Published: July 2024

A Cu(ii) Schiff base complex was grafted onto graphene oxide nanosheets, combined with magnetic iron oxide to form a catalyst for C–H functionalization of indoles at C-3 via a multicomponent reaction, also serving as an antibacterial agent.
Temperature-responsive bioactive glass/polymer hybrids allow for tailoring of ion release
Authors: Nabiyan Afshin , Jin Zhaorui , Brauer Delia S.
Published: July 2024

Controlling the ion release of bioactive glass particles through the formation of a thermoresponsive core–shell hybrid system.
Tough, recyclable and degradable plastics with multiple functions based on supramolecular covalent adaptive networks
Authors: Chen Shi-Yi , Noor Sumaira , Li Zhen , Zhao Zi-Han , Li Cheng-Hui
Published: July 2024

The PPVA-BOL plastic based on supramolecular covalent adaptive networks is tough, recyclable and degradable, and is expected to solve plastic pollution.
Solvent effect induced charge polarity switching from p- to n-type in polyaniline and carbon nanotube hybrid films with a high thermoelectric power factor
Authors: Wang Yizhuo , Dai Xu , Pan Jiahao , Wang Jing , Sun Xu , Li Kuncai , Wang Hong
Published: July 2024

Understanding and controlling the polarity of organic materials is essential for a broad range of organic electronic applications.
MAX-derived B-doped Mo1.33C MXene for ambient electrocatalytic conversion of nitrate to ammonia
Authors: Mu Jianjia , Wang Da , Zhou Shenye , Jia Xianli , Gao Xuan-Wen , Liu Zhaomeng , Luo Wen-Bin
Published: July 2024

We propose a defect-rich Mo1.33C0.9B0.1 MXene electrocatalyst, where the synergistic effect between high-valence Mo sites and the empty-orbital-rich B dopant boosts nitrate adsorption, accelerating the multiple-electron transfer dynamics.
A Mo/PANI co-modified ultra-high nickel NCM9622 cathode composite with excellent cycle stability and high-rate performance for power batteries
Authors: Huang Jinfu , Zhang Liang , Tang Hongyu , Huang Shengyi , Tang Yang , Ma Jianyao , Huang Bin , Li Yanwei , Sun Yiling , Xiao Shunhua , Wang Renheng
Published: July 2024

The ultra-high nickel cathode material NCM9622 is modified by PANI coating and Mo doping, and has excellent cycling stability and rate performance, effectively restrains surface/interface side reactions, reduces cationic mixing and accelerates the Li+ diffusion rate.
Structurally oriented black phosphorus/MXene heterostructured fibers for flexible supercapacitors with enhanced ion transport and capacitive charge storage
Authors: Quan Kunhua , Li Yubing , Xu Panji , Wu Jiayong , Xu Shuaikai
Published: July 2024

Structurally oriented BP/Ti3C2Tx heterostructured fibers with high conductivity, excellent mechanical properties and high specific capacitance were fabricated via electrostatic assembly for high-performance flexible fiber supercapacitors.
Protein aggregation monitoring in cells under oxidative stress: a novel fluorescent probe based on a 7-azaindole-BODIPY derivative
Authors: Herrera-Ochoa Diego , Llano Iván , Ripoll Consuelo , Cybulski Pierre , Kreuzer Martin , Rocha Susana , García-Frutos Eva M. , Bravo Iván , Garzón-Ruiz Andrés
Published: July 2024

The unusual combination of 7-azaindole and BODIPY leads to a multi-emissive fluorescent probe sensitive to protein aggregation in live cells.
A dual-sensing strategy for the early diagnosis of urinary tract infections via detecting biofilm cellulose using aromatic amino acid-capped Au and Ag nanoparticles
Authors: Ramaiah Kavi Bharathi , Suresh Indhu , Srinandan C. S. , Sai Subramanian N. , Rayappan John Bosco Balaguru
Published: July 2024

A dual-sensing strategy is employed for the detection of biofilm cellulose as a UTI biomarker using Tyr-capped gold and silver nanoparticles.
Wearable gold–graphene dry electrode-based headband for effective brain–computer interface applications
Authors: Zheng Yuhang , Sun Yongyue , Li Hongji , Xuan Xiuwei , Li Penghai , Li Mingji
Published: July 2024

A dual-channel headband with Au-doped vertical graphene dry electrodes records electrophysiological signals with low scalp-contact resistance for external-device control.
Carrier generation and compensation mechanism in La2SnO2S3
Authors: Nagafuji Teruya , Osuna Koshiro , Hanzawa Kota , Gake Tomoya , Bae Soungmin , Hu Zhongxu , Katase Takayoshi , Takahashi Akira , Hiramatsu Hidenori , Oba Fumiyasu
Published: July 2024

A combined computational and experimental study of La2SnO2S3 reveals carrier generation and compensation mechanisms associated with its moderate n-type conductivity, where hydrogen impurities and electron self-trapping play crucial roles.
Selective Li ion transport via interpenetrated crystal growth on ZIF-8 seeded nanocomposite membranes
Authors: Clayville Benjamin , Choi Ji Yong , Wagner Christian , Warren William , Park Jihye
Published: July 2024

ZIF-8 based poly(vinylidene) difluoride (PVDF) nanocomposite mixed matrix membranes (MMMs) were successfully prepared via post-synthetic seeded growth of the ZIF-8, demonstrating selective Li ion transport.
Unravelling the intricacies of solvents and sulfur sources in colloidal synthesis of metal sulfide semiconductor nanocrystals
Authors: Mauritz Vincent , Crisp Ryan W.
Published: July 2024

Eight sulfur precursor moieties are reviewed to discuss and develop optimal synthetic strategies for metal sulfide synthesis.
E3 ligases: a ubiquitous link between DNA repair, DNA replication and human disease
Authors: Chauhan Anoop S. , Jhujh Satpal S. , Stewart Grant S.
Published: July 2024

Maintenance of genome stability is of paramount importance for the survival of an organism. However, genomic integrity is constantly being challenged by various endogenous and exogenous processes that damage DNA. Therefore, cells are heavily reliant on DNA repair pathways that have evolved to deal with every type of genotoxic insult that threatens to compromise genome stability. Notably, inherited mutations in genes encoding proteins involved in these protective pathways trigger the onset of disease that is driven by chromosome instability e.g. neurodevelopmental abnormalities, neurodegeneration, premature ageing, immunodeficiency and cancer development. The ability of cells to regulate the recruitment of specific DNA repair proteins to sites of DNA damage is extremely complex but is primarily mediated by protein post-translational modifications (PTMs). Ubiquitylation is one such PTM, which controls genome stability by regulating protein localisation, protein turnover, protein-protein interactions and intra-cellular signalling. Over the past two decades, numerous ubiquitin (Ub) E3 ligases have been identified to play a crucial role not only in the initiation of DNA replication and DNA damage repair but also in the efficient termination of these processes. In this review, we discuss our current understanding of how different Ub E3 ligases (RNF168, TRAIP, HUWE1, TRIP12, FANCL, BRCA1, RFWD3) function to regulate DNA repair and replication and the pathological consequences arising from inheriting deleterious mutations that compromise the Ub-dependent DNA damage response.
Hearing at the Mall: Multibeam Processing Technology Improves Hearing Group Conversations in a Real-World Food Court Environment
Authors: Folkeard Paula , Jensen Niels Søgaard , Parsi Homayoun Kamkar , Bilert Sascha , Scollie Susan
Published: July 2024

Purpose:

This study aimed to evaluate conversation hearing with an adaptive beamforming hearing aid that supports adaptive tracking of multiple talkers in an ecologically valid, real-world food court environment in a busy mall.

Method:

Twenty older adult experienced hearing aid wearers with sensorineural hearing loss were fitted in the lab with binaural receiver-in-the-canal style hearing aids set with two programs, each having a different beamforming strategy. The participant and two researchers then met in a moderately noisy and reverberant food court at a local mall where the participant was asked to listen to a conversation between the two researchers. Participants rated the extent of their agreement with 10 positively worded statements specific to the conversation twice, once for each program. Participants then provided program-preference ratings for seven different aspects of a conversation during which the programs were switched back and forth by the researcher, so that participants were unaware of the condition to which they were listening.

Results:

Real-world subjective ratings for all domains resulted in positive values on average for both programs. Pairwise comparisons indicated that the intervention algorithm had higher absolute ratings on five of the 10 criteria including understanding, clarity, focus, listening effort, and background noise. Ratings for preference between programs indicated a significant preference for the intervention algorithm for all seven criteria.

Conclusions:

In a real-world setting, the use of hearing aids with separate processing of sounds from the front and back hemisphere provided positive subjective ratings. However, following a group conversation with multiple conversation partners, improvements in the algorithm to account for the locations of interlocutors and the natural head turning of the hearing aid wearer that occurs during a conversation by adding and controlling multiple adaptive beams in the front hemisphere significantly influenced preference for all aspects rated.
Characteristics of Children and Youth Referred for Language Assessment at Different Ages
Authors: de Bree Elise , Wiefferink Karin , Gerrits Ellen
Published: July 2024

Purpose:

Early detection of language delays is essential, as language is key for academic outcomes, well-being, and societal participation. Previous studies have focused on undetected delays in young children. Much less is known about referrals at older ages. In this study, we aimed to (a) establish how many children are referred at toddler age (2–3 years) and how many at lower elementary (4–7 years), upper elementary (8–12 years), and high school (13–16 years) age; (b) evaluate characteristics of the referred children and adolescents across age groups; and (c) assess whether the ensuing classification (no language disorder [LD], developmental LD, LD + additional problems) differed across age groups.

Method:

We used the 2010–2014 database of the Dutch federation of speech and hearing centers, containing 18,894 cases with target ages. We established the number of referrals in each age group (Q1) and assessed the composition of the age groups in terms of speech, language, behavioral, and cognitive outcomes (Q2), as well as in terms of classification (Q3). To answer Q2 and Q3, we conducted chi-squared analyses with the toddler group as reference group.

Results:

Late-identified LDs exist: There were new referrals in all age groups. Compared to older age groups, the toddler group contained fewer girls and multilingual children. The toddler group also contained fewer children without an LD and more children with LD + additional problems.

Conclusions:

Reassuringly, children with multiple language problems are referred earliest. However, late-identified LDs exist, even at high school age. Girls and multilingual children tend to be missed at younger ages. More work on awareness and identification of language delays is needed, requiring awareness, knowledge, and tools for educational professionals.
Multimodal Technologies for Remote Assessment of Neurological and Mental Health
Authors: Ramanarayanan Vikram
Published: July 2024

Purpose:

Automated remote assessment and monitoring of patients' neurological and mental health is increasingly becoming an essential component of the digital clinic and telehealth ecosystem, especially after the COVID-19 pandemic. This review article reviews various modalities of health information that are useful for developing such remote clinical assessments in the real world at scale.

Approach:

We first present an overview of the various modalities of health information—speech acoustics, natural language, conversational dynamics, orofacial or full body movement, eye gaze, respiration, cardiopulmonary, and neural—which can each be extracted from various signal sources—audio, video, text, or sensors. We further motivate their clinical utility with examples of how information from each modality can help us characterize how different disorders affect different aspects of patients' spoken communication. We then elucidate the advantages of combining one or more of these modalities toward a more holistic, informative, and robust assessment.

Findings:

We find that combining multiple modalities of health information allows for improved scientific interpretability, improved performance on downstream health applications such as early detection and progress monitoring, improved technological robustness, and improved user experience. We illustrate how these principles can be leveraged for remote clinical assessment at scale using a real-world case study of the Modality assessment platform.

Conclusion:

This review article motivates the combination of human-centric information from multiple modalities to measure various aspects of patients' health, arguing that remote clinical assessment that integrates this complementary information can be more effective and lead to better clinical outcomes than using any one data stream in isolation.
A new method for surge arrester placement in high‐voltage substations considering environmental effects
Authors: Safaei Faridoddin , Niasati Mohsen
Published: July 2024

Conventional approaches for determining the optimal locations of surge arresters (SAs) can result in an unnecessary increase in the number of these devices in high‐voltage substations. This study presents an effective technique for determining the optimal locations of SAs. The lightning back flashover (BF) and switching over‐voltages are predicted with the accurate modeling of the transient behavior of all elements of high‐voltage substations and transmission lines, considering the effect of environmental conditions. Also, the proposed limiting parameter Monte Carlo (MC‐LP) method is utilized to correctly select the probability distribution of the possible strokes for predicting the insulation risk (IR) of a transformer based on transient over‐voltage on the transformer end. Therefore, the most appropriate location to install an SA can be determined with a minimum number of calculations using the structural data of the substation, lines connected to it, and the transformer. Simulations are based on experimental results, and the number of calculations significantly decreases using the proposed algorithm. Simulations of the sample network and implementation of the proposed algorithm with MATLAB and EMTP‐RV prove the efficiency of the proposed method for optimum SA placement.
Testing particle acceleration in blazar jets with continuous high-cadence optical polarization observations
Authors: Liodakis Ioannis , Kiehlmann Sebastian , Marscher Alan P. , Zhang Haocheng , Blinov Dmitry , Jorstad Svetlana G. , Agudo Iván , Benítez Erika , Berdyugin Andrei , Bonnoli Giacomo , Casadio Carolina , Chen Chien-Ting , Chen Wen-Ping , Ehlert Steven R. , Escudero Juan , Grishina Tatiana S. , Hiriart David , Hsu Angela , Imazawa Ryo , Jermak Helen E. , Jose Jincen , Kaaret Philip , Kopatskaya Evgenia N. , Lalchand Bhavana , Larionova Elena G. , Lindfors Elina , López José M. , McCall Callum , Morozova Daria A. , Palaiologou Efthymios , Pandey Shivangi , Poutanen Juri , Rakshit Suvendu , Reig Pablo , Sasada Mahito , Savchenko Sergey S. , Shablovinskaya Elena , Neha Sharma , Shrestha Manisha , Steele Iain A. , Troitskiy Ivan S. , Troitskaya Yulia V. , Uemura Makoto , Vasilyev Andrey A. , Weaver Zachary , Wiersema Klaas , Weisskopf Martin C.
Published: July 2024

Variability can be the pathway to understanding the physical processes in astrophysical jets. However, the high-cadence observations required to test particle acceleration models are still missing. Here we report on the first attempt to produce continuous, > 24 hour polarization light curves of blazars using telescopes distributed across the globe, following the rotation of the Earth, to avoid the rising Sun. Our campaign involved 16 telescopes in Asia, Europe, and North America. We observed BL Lacertae and CGRaBS J0211+1051 for a combined 685 telescope hours. We find large variations in the polarization degree and angle for both sources on sub-hour timescales as well as a ∼180° rotation of the polarization angle in CGRaBS J0211+1051 in less than two days. We compared our high-cadence observations to particle-in-cell magnetic reconnection and turbulent plasma simulations. We find that although the state-of-the-art simulation frameworks can produce a large fraction of the polarization properties, they do not account for the entirety of the observed polarization behavior in blazar jets.
Vergleich der Herstellungsmethoden homöopathischer Arzneimittel in
verschiedenen homöopathischen Arzneibüchern weltweit – Teil 1
Authors: Buchheim-Schmidt Susann , Schwarzbach Ralf
Published: July 2024

Im vorliegenden Beitrag werden die allgemeinen Herstellungsmethoden der
wichtigsten homöopathischen Pharmakopöen weltweit verglichen. Gemeinsamkeiten
und Unterschiede bezüglich der Herstellung von Urtinkturen,
Potenzierungsverfahren (Hahnemann oder Korsakoff), Anzahl sowie Art und Weise
der Schüttelschläge, Verreibungszeit und Globuligrößen – auch im Vergleich zu
den historischen Quellen in der „Reinen Arzneimittellehre“, den „Chronischen
Krankheiten“ und dem „Organon“ – werden herausgearbeitet. Die Ergebnisse werden
unter toxikologischen Gesichtspunkten und in Relation zur praktischen Arbeit
homöopathischer Therapeuten diskutiert.
Polaritätsanalyse – ein aktueller Überblick
Authors: Lucae Christian
Published: July 2024

Eine besondere Methode innerhalb der Homöopathie ist die Polaritätsanalyse. Sie
wurde vom Schweizer Kinderarzt Dr. Heiner Frei entwickelt und beruht auf einem
Frühwerk der Homöopathie – Bönninghausens Therapeutischem Taschenbuch.
Grundlagen, Entstehung, Entwicklung und der aktuelle Stand der Polaritätsanalyse
werden in diesem Beitrag dargestellt.
Reactive Arthritis Following COVID-19 Vaccination: Report of Three
Cases
Authors: Tasgöz Cemre , Acar Emre Ali , Sülükcü Seref , Uslu Sadettin , Gündüz Ozgül Soysal
Published: July 2024

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative
agent of the coronavirus disease 19 (COVID-19) pandemic, which has affected the
entire world. The development of COVID-19 vaccines has helped to slow the spread
of the virus. However, as with vaccines against other infectious diseases,
adverse events can occur with COVID-19 vaccines. Here we present 3 cases of
acute arthritis following COVID-19 vaccination and a comprehensive review of the
existing literature.
Comparison of stent patency between EUS-guided hepaticogastrostomy with bridging and endoscopic transpapillary biliary drainage for hilar obstruction
Authors: Takeshita Kotaro , Hijioka Susumu , Nagashio Yoshikuni , Maruki Yuta , Ohba Akihiro , Kawasaki Yuki , Takasaki Tetsuro , Yagi Shin , Agarie Daiki , Hara Hidenobu , Hagiwara Yuya , Yamashige Daiki , Okamoto Kohei , Fukuda Soma , Kuwada Masaru , Chatto Mark , Kondo Shunsuke , Morizane Chigusa , Ueno Hideki , Saito Yutaka , Okusaka Takuji
Published: July 2024

Background and study aims Endoscopic ultrasound-guided hepaticogastrostomy with bridging between the left and right bile ducts is an alternative to endoscopic transpapillary drainage for malignant hilar biliary obstruction. We aimed to analyze the long-term stent patency of endoscopic ultrasound-guided hepaticogastrostomy with bridging.

Patients and methods Patients who underwent endoscopic ultrasound-guided hepaticogastrostomy with bridging between April 2018 and July 2023 were retrospectively analyzed. We retrospectively compared the stent patency of these patients with that of the individuals who underwent endoscopic transpapillary drainage-multi-stenting using unmatched (entire) and propensity score-matched cohorts.

Results Endoscopic ultrasound-guided hepaticogastrostomy with bridging had a technical success rate of 90% (18/20). Adverse events were minimal. The number of clinical success cases was 17 and 82 for endoscopic ultrasound-guided hepaticogastrostomy with bridging using metallic stent and endoscopic transpapillary drainage-multi-stenting, respectively. The recurrent biliary obstruction rate was 17.6% and 58.5% for endoscopic ultrasound-guided hepaticogastrostomy with bridging and endoscopic transpapillary drainage-multi-stenting, respectively; the median time to recurrent biliary obstruction (days) was significantly longer for endoscopic ultrasound-guided hepaticogastrostomy with bridging in the entire (not reached vs. 104, P=0.03) and propensity score-matched (183 vs. 79, P=0.05) cohorts. The non-recurrent biliary obstruction rate for endoscopic ultrasound-guided hepaticogastrostomy with bridging was 91.6% at 3 and 6 months and 57% at 12 months. Multivariate analyses revealed that endoscopic ultrasound-guided hepaticogastrostomy with bridging contributed to a lower recurrent biliary obstruction incidence (hazard ratio, 0.31, P=0.05) without significant difference.

Conclusions Stent patency was significantly better for endoscopic ultrasound-guided hepaticogastrostomy with bridging. However, future prospective studies are needed.
Effect of chewing gum in bowel preparation for patients undergoing small bowel and colon capsule endoscopy: Systematic review with meta-analysis
Authors: Jensen Sofie Sajan , Deding Ulrik , Hansen Lea Østergaard , Koulaouzidis Anastasios , Bjørsum-Meyer Thomas
Published: July 2024

Background and study aims Quality of bowel preparation and successful transit are critical factors for complete small bowel capsule endoscopy (SBCE) and colon capsule endoscopy (CCE). The aim of this systematic review with meta-analysis was to assess the impact of chewing gum as part of the bowel preparation regimen on the completion rate in both SBCE and CCE.

Methods A systematic literature search was conducted in PubMed, Cochrane, Web of Science and Embase. Data were extracted upon quality assessment of included studies. Two reviewers conducted the screening process according to the Preferred Reporting Items for Systematic Reviews and Meta-Analysis. Eighty-four studies met the search criteria and four randomized controlled trials were included in the meta-analysis, these were assessed for bias using Minors. Pooled completion rate of SBCE studies was defined as the primary outcome.

Results Three randomized controlled trials were SBCE studies and one was a CCE study. The pooled completion rate (91%) was not significantly higher in SBCE patients who were given chewing gum after capsule ingestion compared to those who were not (85%). Variance information was not reported in all studies, and therefore, pooled transit time estimates could not be calculated.

Conclusions Chewing gum has a good safety profile but has only been used as a booster in one CCE study and a few SBCE studies. More prospective randomized controlled trials, therefore, are needed to investigate the efficacy of chewing gum for achieving complete capsule examination.
Investigational Treatment of Congenital Hypogonadotropic Hypogonadism
in Infants
Authors: Ren Xiaoya , Wang Yi , Liu Ying , Gong Chunxiu
Published: July 2024

The aim of the study was to investigate whether the administration of
gonadotropins to mimic the physiological development of infants with congenital
hypogonadotropic hypogonadism (CHH) after birth can facilitate testicular
descent, penile growth, and ultimately preserve fertility. This study included
eight infants with CHH who received a gonadotropin-releasing hormone (GnRH) pump
or human chorionic gonadotropin (HCG) combined with human menopausal
gonadotropin (HMG) therapy at Beijing Children's Hospital from August 2018
to March 2023. The age of the infants ranged from 6 months to 2 years. 2. For
literature review, a search was conducted in the PubMed database using the
keywords “congenital hypogonadotropic hypogonadism,” “infants,” and
“mini-puberty” up until June 2023. After 1–3 months of treatment, significant
increases were observed in PL and TV. The testes descended from the inguinal
region to the scrotum. Serum T and INH-B levels increased from being
undetectable to 737.1±409.5 ng/dl and from 47.88±23.03 to 168.94±59.34 pg/ml,
respectively. In a comparative literature review of 22 infants with CHH, the age
at treatment initiation ranged from 0.5 to 7.9 months. Treatment involved
various dosages and durations, ranging from 2 to 6 months of subcutaneous
injections of LH and FSH. Both therapies successfully improved PL, TV, and
testicular descent; reduced the need for surgery; and were safe. This is the
first report of the use of a GnRH pump for the treatment of infant CHH.
Ein T-Wellen-Twist im EKG – ein Fallbericht aus der Arztpraxis
Authors: Ruoß Isabell
Published: July 2024

Anhand der vorliegenden Kasuistik soll die entscheidende Rolle des Erkennens von Hoch-Risiko-EKGs bei Patienten mit Verdacht auf ein akutes Koronarsyndrom (ACS) verdeutlicht werden. Bei einem 59-jährigen Patienten zeigte sich in einem beschwerdefreien Intervall im EKG das Wellens-Zeichen, als Hinweis auf ein NSTE-ACS (Nicht-ST-Strecken-Hebung-[NSTE-]ACS). Bei intermittierender Belastungsdyspnoe und thorakalem Brennen mit langen beschwerdefreien Intervallen war die Diagnosestellung bei diesem Patienten eine Herausforderung. In der aktualisierten Leitlinie von 2023 zum Management des akuten Koronarsyndroms wurde erstmals das Wellens-Zeichen als NSTE-Hoch-Risiko-EKG aufgenommen, da diese Patienten ein hohes Risiko besitzen, einen Vorderwandinfarkt zu entwickeln. Durch das Erkennen von Hoch-Risiko-EKGs in der Akutmedizin kann ein effizientes Zeitmanagement für invasive Diagnostik und Therapie erzielt werden.