bluuebunny/crossref_metadata_2025 huggingface dataset:
From Pan-Arabism to Pharaonism: Egypt’s Gradual Change of National Identity during the Sisi Era
Authors: Setiyono Mozes Adiguna
Published: August 2023

Many scholars argue that globalization will replace local cultures with global cultures. This writing rejects the argument. On the contrary, the world is seeing the revival of indigenous cultures and efforts to redefine national identities in several countries, including Egypt. In the Arab world, this phenomenon was caused by the Arab Spring. Egypt has been Arabicized for centuries, and the Egyptians tend to define themselves as Arabs. Abdel Fattah El-Sisi, who has been the president of Egypt after deposing Mohamed Morsi, is reviving Egypt’s Pharaonic identity. This study uses a qualitative approach by collecting President Abdel Fattah El-Sisi or Egypt-related online news to be analyzed and used to prove the gradual change of Egyptian national identity. Domestic and foreign policies define the identity of a state. Sisi’s decisions to ban the Pan-Islamist Muslim Brotherhood and improve relations with Israel indicate his effort to distinguish Egypt from Islamic and Arab identities. Egypt’s transition from Arab identity to Pharaonic identity can be seen in its new capital’s architectural designs and Egyptian government-initiated cultural events. All of these transitions are strengthened by the government’s decision to introduce hieroglyphs into the Egyptian school curriculum.
Keywords: Egypt, Pharaonism, identity, culture, globalization
 
Banyak penstudi berpendapat bahwa globalisasi akan menggantikan budaya lokal dengan budaya global. Tulisan ini menolak pendapat tersebut. Sebaliknya, dunia sedang menyaksikan kebangkitan budaya-budaya pribumi dan upaya-upaya pendefinisian ulang identitas nasional di beberapa negara, termasuk Mesir. Dalam dunia Arab, fenomena ini disebabkan oleh Arab Spring. Mesir telah mengalami Arabisasi selama berabad-abad dan masyarakat Mesir cenderung mendefinisikan diri sebagai orang-orang Arab. Abdel Fattah El-Sisi, yang menjadi presiden Mesir setelah menggulingkan Mohamed Morsi, sedang membangkitkan identitas Faraonis Mesir. Studi ini menggunakan pendekatan kualitatif dengan mengumpulkan berita-berita daring yang berkaitan dengan Mesir atau Presiden Abdel Fattah El-Sisi untuk dianalisis dan digunakan untuk membuktikan perubahan bertahap identitas nasional Mesir. Kebijakan dalam negeri dan luar negeri menunjukkan identitas dari sebuah negara. Keputusan Sisi untuk melarang Ikhwanul Muslimin yang Pan-Islamis serta memperbaiki hubungan dengan Israel mengindikasikan upayanya untuk memisahkan Mesir dari identitas Islam dan Arab. Transisi Mesir dari identitas Arab ke identitas Faraonis dapat dilihat pada desain arsitektur ibukota baru Mesir serta acara-acara kebudayaan yang diinisiasi oleh pemerintah Mesir. Semua ini diperkuat oleh keputusan pemerintah untuk memperkenalkan hieroglif dalam kurikulum pendidikan Mesir.
Kata-kata Kunci: Mesir, Faraonisme, identitas, budaya, globalisasi
Violence against Indian Dalit Women under Narendra Modi Government: Johan Galtung's Cultural Violence Analysis
Authors: Agusti Santria , Dewi Karina Utami
Published: August 2023

Artikel ini akan membahas tentang kekerasan yang dihadapi perempuan Dalit India pada masa pemerintahan Narendra Modi. Kekerasan kultural merupakan bagian dari pelanggaran Hak Asasi Manusia (HAM) yang salah satunya terjadi di kawasan Asia Selatan yaitu India. Fenomena kekerasan kultural terhadap perempuan di India, khususnya pada kasta Dalit menjadi sesuatu yang menarik untuk dibahas, sebagaimana kekerasan yang dihadapi perempuan Dalit di India sudah terjadi sejak zaman kuno hingga sekarang pada masa pemerintahan Narendra Modi. Pemerintahan Modi tidak dapat memberikan perubahan yang besar terhadap hidup dan hak-hak perempuan Dalit. Hal ini ditunjukkan dengan masih adanya kebijakan yang membuat perempuan Dalit menderita. Penelitian ini bertujuan untuk menganalisis bagaimana kekerasan terhadap perempuan Dalit India di pemerintahan Modi terjadi menggunakan teori kekerasan kultural yang dicetuskan oleh Johan Galtung. Dalam penelitian ini, ditemukan bahwa nilai agama menjadi faktor yang dominan mendorong terjadinya kekerasan kultural terhadap perempuan Dalit India. Selain itu, tingkat patriarki yang tinggi menunjukkan bahwa kekerasan kultural ini merupakan sebuah fenomena yang tidak akan pernah berhenti pada setiap era pemerintahan.
Kata-kata Kunci: Perempuan Dalit India, Kekerasan Kultural, Narendra Modi
 
This article will discuss the violence faced by Indian Dalit women during the reign of Narendra Modi. Cultural violence is part of human rights violations, one of which occurs in the South Asian region, India. The phenomenon of cultural violence against women in India, especially the Dalit caste, is an interesting topic to discuss, whereas the violence faced by Dalit women in India has occurred ever since ancient times until the current era during the reign of Narendra Modi. The Modi government has not been able to make a significant difference in the lives and rights of Dalit women. This is shown by the existence of policies that make Dalit women suffer. This study aims to analyze how the violence against Indian Dalit women in the Modi government occurs using the theory of cultural violence that was coined by Johan Galtung. This study found that the religious aspect was the dominant factor driving the occurrence of cultural violence against Indian Dalit women. In addition, the high level of patriarchy shows that this cultural violence is a phenomenon that will never diminish in every governmental era.
Keywords: Indian Dalit Women, Cultural Violence, Narendra Modi
The Collaboration between Dior and Balinese Endek Woven within The Framework of Indonesian Cultural Diplomacy
Authors: Dewi Putu Ratih Kumala , Wiranata I Made Anom
Published: August 2023

Endek Bali has received world attention after a well-known fashion company from France, Dior, used Balinese endek woven fabric in its 2021 SpringSummer collection. Using the concepts of cultural diplomacy and nation branding and employing qualitative method, this study aims to explain the use of Balinese endek in supporting Indonesia’s nation branding through collaboration with Dior. The data was collected through in-depth interviews, literature studies, as well as thorough analysis of official statements collected from the Bali provincial government and the Ministry of Foreign Affairs of the Republic of Indonesia. The study shows that the Indonesian government plays an important role in facilitating Indonesian cultural diplomacy using Balinese endek woven, which was carried out in colaboration with Christian Dior, where the Indonesian government act as a communicator between the fashion brand and the endek weavers, marking a pattern of cultural diplomacy relations between the government and the private sector, which further strengthen Indonesia’s nation branding as a culturally rich country with creative human resources.
Keywords: Christian Dior, Cultural Heritage, Diplomacy, Endek Bali, Nation Branding
Tenun endek Bali mendapat perhatian dunia setelah perusahaan fesyen ternama asal Perancis, Dior, menggunakan kain tenun endek Bali sebagai koleksi tahun 2021 untuk busana musim semi dan musim panas. Dengan menggunakan konsep diplomasi budaya dan nation branding serta metode kualitatif, penelitian ini bertujuan menjelaskan penggunaan tenun endek Bali dalam menunjang nation branding Indonesia melalui kolaborasi dengan Christian Dior. Pengumpulan data dilakukan melalui proses wawancara, studi literatur terkait, serta analisis pernyataan resmi pemerintah provinsi Bali dan Kementerian Luar Negeri. Hasil penelitian menunjukkan bahwa Pemerintah Indonesia memiliki peranan penting dalam memfasilitasi diplomasi budaya Indonesia menggunakan tenun endek Bali yang dilakukan melalui kolaborasi dengan Dior, membentuk pola hubungan diplomasi kebudayaan antara pemerintah dan sektor swasta, yang lebih lanjut memperkuat nation branding Indonesia sebagai negara yang kaya ragam budaya dan sumber daya manusia kreatif.
Kata-kata kunci: Christian Dior, Diplomasi, Endek Bali, Nation Branding, Warisan Budaya
Persepsi dan Pemaknaan Anak Muda terhadap Tayangan Konten Pemuda Tersesat di Channel YouTube Majelis Lucu Indonesia
Authors: Muhammad Gaffari
Published: August 2023

The presence of the Pemuda Tersesat show which is broadcast through the Majelis Lucu Indonesia channel seems to create a new breakthrough that presents a collaboration between comedians and preachers on YouTube media. With the concept of answering absurd, unique, and humorous questions posed by the audience, this content became popular and attracted the attention of the audience, and gave rise to a group of fans who are also known as Pemuda Tersesat. However, on the other side, there are also parties who do not agree with the presence of this content because it is considered to be discussing religion jokingly and not seriously. The purpose of this study is to be able to answer the formulation of the problem, namely to find out the perception of youth about the Pemuda Tersesat show on the Majelis Lucu Indonesia’s YouTube channel, the reception of youth as viewers, and what the Pemuda Tersesat figure that imagines by youth viewers. To answer the research objectives, the researcher used a qualitative approach with reception analysis methods, and conducted in-depth interviews with purposively selected informants. The results of this study indicate that audience perceptions are formed through 3 factors, namely: Audience trust, partiality (Hostile Media Perception), and influence (Third Person Perception). The results of the audience receiption in this study also show how they interpret the concept of Pemuda Tersesat show and the figures of Pemuda Tersesat that they imagine. Each informant is unique in giving his own meaning, actively and creatively, which is influenced by differences in the social conditions of the audience.

Keywords: Pemuda Tersesat content, youth, perception, reception, active audience
Strategi Public Relations Mandalika Grand Prix Association (MGPA) dalam Manajemen Event World Superbike 2022
Authors: Ni Putu Sri Widyastini Susila  , Santi Isnaini
Published: August 2023

Advances in technology and the digitalization of information have resulted in the media convergence movement growing and technological advances becoming more rapid. In today's media convergence era, there are various options in event management. This study aims to find out how the role of the Mandalika Grand Prix Association (MGPA) in the 2022 World Superbike event in Mandalika amidst media convergence. More than 50 thousand spectators came to watch the 2022 WSBK in Mandalika. This figure exceeded the initial target of 45 thousand viewers. One of the aspects that made the WSBK 2022 event successful was the event promotion strategy that was able to bring in tens of thousands of spectators. This success is inseparable from the role of Public Relations in branding and making events attractive. Public Relations must be observant in packaging events so as not to generate risks and issues in the community. This research is a constructivist paradigm and uses a descriptive qualitative approach, using the Ronald D. Smith model which analyzes the Public Relations strategy through 4 stages that identify 9 steps in planning public relations activities. From the research results, it was found that MGPA's Public Relations succeeded in utilizing technological advances as a means of event management to become more effective. able to build the image of World Superbike 2022 to become an event that is trusted by the community and its stakeholders. MGPA's Public Relations has succeeded in carrying out four PR roles in building the company's brand image, namely: (1) as a communicator for company stakeholders; (2) making publications; (3) carrying out Corporate Social Responsibility (CSR) activities; and (4) building the company's image program.
Analytical upgrade of a methodology based on UHPLC-MS/MS for the analysis of endocrine disrupting compounds in greywater
Authors: Turull Marta , Buttiglieri Gianluigi , Vazquez Valeria , Rodriguez-Mozaz Sara , Santos Lúcia H.M.L.M.
Published: August 2023

A multi-residue analytical methodology for the determination of 25 endocrine disrupting compounds (EDCs), encompassing various chemical classes (hormones, antimicrobials, preservatives, plasticizers, stimulants, alkylphenolic compounds, anticorrosives, and organophosphorus flame retardants), has been upgraded for the analysis of greywater. The methodology is based on solid phase extraction (SPE) followed by ultra-high-performance liquid chromatography-tandem mass spectrometry (UHPLC-MS/MS). The optimized methodology achieved recoveries between 63% and 146% for all compounds, with MDLs ranging from 0.3 to 141 ng/L. Most of the compounds showed a pronounced signal suppression in the laundry greywater tested, and therefore, quantification was performed with a matrix-matched calibration curve to surpass the matrix effects observed (between -100% and 106%). Additionally, polyvinylidene fluoride (PVDF) membrane filters were selected among several filter types as the most suitable for greywater filtration. The upgraded methodology allowed the detection of 14, four and four EDCs in laundry, kitchen and shower/sink greywater, respectively. Caffeine was the only compound detected in all types of greywater, showing the highest concentrations (> 40,000 ng/L in kitchen greywater, and 2,360 ng/L in laundry greywater), followed by methylparaben and 1H-benzotriazole (1,607 and 776 ng/L, respectively, in laundry greywater). This analytical methodology constitutes an important tool for monitoring different families of contaminants in greywater, a poorly studied matrix, which is nowadays being considered as a future source of freshwater, contributing to overcoming problems of water scarcity. Water monitoring thus helps to guarantee water quality in water reuse practices and to understand EDC exposure patterns and their potential environmental impact.
Amasya ve Çevresinde Kurulan Para Vakıfları Üzerine Bir İnceleme
Authors: TÜRKMEN Ömer Sait
Published: August 2023

Para vakıfları daha çok sosyal amaçlara yönelik kurulmuş vakıflardır. Osmanlı Devleti’nde toplumun ihtiyaç duyduğu eğitim, sağlık, bayındırlık hizmetleri ile hayrî ve dinî hizmet ve yapıların finansmanı para vakıfları sayesinde hayır sahipleri vakfettikleri paralarla karşılanmıştır. Ayrıca ekonomik sıkıntı çeken esnaf ve halkın nakit ihtiyaçları da düşük muamele oranlarıyla karşılanmıştır.

Amasya ve çevresinde 1633- 1914 yılları arasında kurulan 188 para vakfı ise mahalle ya da köylerde hizmet veren dinî ve sosyal kurumların binalarının ve hizmetlerinin devamlılığının sağlanması amacıyla kurulmuştur. Aynı zamanda kuruldukları yerlerdeki halkın nakit ihtiyaçlarını karşılamışlardır. Belirli muamele oranlarıyla aşırı faizciliğin de önüne geçmiştir. Bu çalışmada Osmanlı Devleti döneminde Amasya ve çevresinde kurulan para vakıflarının sayıları, vakıf kurucuların özellikleri ve sosyal statüleri, vakfedilen para miktarları ve hizmet amaçları belirtilmeye çalışılacaktır.
The Possible Role of Anti- and Pro-Tumour-Infiltrating Lymphocytes on Pathologic Complete Response in Early Breast Cancer Patients Treated with Neoadjuvant Systemic Therapy
Authors: Geršak Klara , Geršak Blaž Matija , Gazić Barbara , Klevišar Ivančič Andreja , Drev Primož , Ružić Gorenjec Nina , Grašič Kuhar Cvetka
Published: August 2023

Tumour microenvironment, composed of pro- and anti-tumour immune cells, affects cancer cells behaviour. We aimed to evaluate if tumour-infiltrating lymphocyte (TIL) density and TILs subtypes in core biopsies at diagnosis of breast cancer patients could predict pathologic complete response (pCR; ypT0/is ypN0) from neoadjuvant systemic therapy (NST). The TIL subtypes were determined based on the proportions of presumably anti-tumour (CD8+, CXCL13+) and pro-tumour (PD-1+, FOXP3+) immune cells. A prospective, non-interventional study including 171 participants undergoing NST was performed. The median TIL density for the entire cohort was 10% (IQR: 3.5-23.8), and 59 (35%) patients achieved pCR. TIL density was positively associated with pCR (univariately and multivariably). In the multivariable logistic regression model, TIL density was an independent predictor of pCR (p=0.012, OR 1.27; 95% CI 1.05-1.54) when controlled for age (p=0.232), Ki-67 (p=0.001), node-negative status (p=0.024), and HER2+/triple negative vs luminal B-like subtype (p<0.001). In our sample, higher proportions of PD-1+ TILs and FOXP3+ TILs were associated with a higher probability of pCR but the association was not statistically significant. In the exploratory multivariable analysis, we showed that only higher CD8+ TILs were associated with pCR. In conclusion, TIL density and its subtypes are associated with pCR.
Voyaging Beyond Chalkboards: Unleashing Tomorrow's Minds through AI-Driven Frontiers in Literature and Language Education
Authors: Eslit Edgar R.
Published: August 2023

Amidst the dynamic landscape of education, this paper embarks on a transformative journey that explores the integration of Artificial Intelligence (AI) in literature and language education. Through a qualitative exploratory approach, purposeful and maximum variation sampling method, the researcher delves into the experiences of educators and learners, unraveling the multifaceted dimensions of AI-driven pedagogy in SMC. Drawing upon a theoretical framework encompassing Constructivism, Connectivism, and Socio-Cultural Theory, the study examines AI's role in reshaping pedagogical landscapes, fostering critical thinking, and expanding access to education. The results resonate with participants' narratives, unveiling AI's potential in fostering personalized learning pathways, enhancing collaborative engagement, and bridging digital divides. Ethical considerations in AI education are explored, leading to the proposition of responsible guidelines. These findings underline the transformative power of AI in education, aligned with the institution's commitment to quality education and innovation. Overall, the study calls for ongoing exploration, emphasizing the qualitative research method's depth and richness, as well as the theoretical framework's guidance in realizing the study's objectives. As AI continues to shape education's frontiers, this research underscores the significance of adaptability, ethical awareness, and holistic engagement for school administrators, educators, learners, and researchers alike.
Suturing in Gynaecological Laparoscopic Surgery: A Systematic Review of Loop and Knot Security, Varying with the Suture and Sequences, Throws, Rotation and Destabilisation of Half-Knots or Half-Hitches
Authors: Koninckx Philippe R , Ussia Anastasia , Wattiez Arnaud , Kondo William , Romeo Armando
Published: August 2023

Surgical knots are sequences of half-knots (H) or half-hitches (S), defined by their number of throws, by an opposite or similar rotation compared with the previous one and for half-hitches, whether sliding (s) or blocking (b). Opposite rotation results in (more secure) symmetric (s) knots, similar rotation in asymmetric (a) knots, and changing active and passive ends has the same effect as changing rotation. Loop security is the force to keep tissue together after a first half-knot or sliding half-hitches. With polyfilament sutures H2, H3, SSs and SSsSsSs have a loop security of 10, 18, 28 and 48 Newton (N), respectively. With monofilament sutures, they are only 7, 16, 18 and 25N. Since many knots can reorganise, the definition of knot security as the force at which the knot opens or the suture breaks should be replaced by the clinically more relevant percentage of clinically dangerous and insecure knots. Secure knots with polyfilament sutures require a minimum of 4 or 5 throws, but the risk of destabilisation is high. With monofilament sutures, only 2 symmetric+4 asymmetric blocking half-hitches are secure. In conclusion, half-hitch sequences are recommended since mandatory for monofilament sutures, adding flexibility for loop security with less risk of destabilisation.
Multimodality Imaging in Advanced Heart Failure for Diagnosis, Management and Follow-Up. A Comprehensive Review
Authors: Pergola Valeria , Cameli Matteo , Mushtaq Saima , Mattesi Giulia , D’Andrea Antonello , Guaricci Andrea Igoren , Pastore Maria Concetta , Amato Filippo , Dellino Carlo maria , Motta Raffaella , Perazzolo Marra Martina , Pedrinelli Roberto , Dellegrottaglie Santo , Iliceto Sabino , Nodari Savina , Perrone Filardi Pasquale , Pontone Gianluca
Published: August 2023

Advanced heart failure (AHF) presents a complex landscape with challenges spanning diagnosis, management, and patient outcomes. In response, the integration of multimodality imaging techniques has emerged as a pivotal approach. This comprehensive review delves into the profound significance of these imaging strategies within AHF scenarios. Multimodality imaging, encompassing echocardiography, cardiac magnetic resonance imaging (CMR), and cardiac computed tomography (CCT), stands as a cornerstone in the care of patients with both short- and long-term mechanical support devices. These techniques facilitate precise device selection, placement, and vigilant monitoring, ensuring patient safety and optimal device functionality. In the context of orthotopic cardiac transplant (OTC), the role of multimodality imaging remains indispensable. Echocardiography offers invaluable insights into allograft function and potential complications. Advanced methods, like speckle tracking echocardiography (STE), empower the detection of acute cell rejection. CMR and CCT further enhance diagnostic precision, especially concerning allograft rejection and cardiac allograft vasculopathy. This comprehensive imaging approach goes beyond diagnosis, shaping treatment strategies and risk assessment. By harmonizing diverse imaging modalities, clinicians gain a panoramic understanding of each patient's unique condition, facilitating well-informed decisions. Thus, this review underscores the irreplaceable role of multimodality imaging in elevating patient outcomes, refining treatment precision, and propelling advancements in the evolving landscape of advanced heart failure management.
Low Frequency Electrical Conductivity of Trabecular Bone: Insights from In Silico Modeling
Authors: Cervantes María José , Basiuk Lucas Osvaldo , González-Suárez Ana , Manuel Carlevaro C. , Irastorza Ramiro M.
Published: August 2023

Background: Electrical conductivity of trabecular bone at 100 kHz was recently reported as a good predictor of bone volume fraction. However, to quantify its relationship with the free water (or physiological solution) content and between the conductivities of its constituents, is still unclear. Methods: In this contribution, in silico models inspired by microCT images of trabecular bovine samples were used to build realistic geometries. Finite Element Method was applied to solve the electrical problem and to robustly fit the conductivity of the constituents with literature data. The obtained effective electrical conductivity was compared to Bruggeman three media mixture model: physiological solution, bone marrow and bone matrix. Results: The values for physiological solution plus bone marrow and bone matrix that captured better the bone volume fraction in the two media Finite Element model were: σps+bm = 298.4 mS/m and σb = 21.0 mS/m, respectively. Additionally, relative good results were obtained by a three media Bruggeman mixture model with σbm= 103 mS/m, σb= 21.0 mS/m, and σps= 1200 mS/m. Simple linear relationships between the proportions of constituents depending on bone volume fraction were tested. Degree of anisotropy and fractal dimension do not show detectable changes in effective conductivity. Conclusions: These results provided some useful findings for simulation purposes: first, a higher value of electrical conductivity of bone marrow has to be used in order to obtain similar values to those experimental published data. Second, anisotropy is not detectable by conductivity measurements for small trabecular samples (cube 5 mm). Finally, the simulations presented here showed a relatively good fitting of the mixture Bruggeman model which potentially would allow both, accounting for the free water content and re-scaling the model for whole bone electrical simulations.
Joint Multidimensional Pattern for Spectrum Prediction Using GNN
Authors: Fang Shengliang , Wen Xiaomin , Xu Zhaojing , Liu Han
Published: August 2023

Generally, when cognitive radio users are in Underlay mode, through the analysis of the electromagnetic spectrum in time, frequency, space, and field of multiple dimensional data accounts for judging the inherent correlation of the radio spectrum used/idle state, this is the realization of cognitive radio users (secondary users, SUs) efficient access to the foundation of the limited spectrum resources. Therefore, how to efficiently use of spectrum status of each SU implementation of reception multidimensional combination forecasting is the core of this paper addressing the problem. In this paper, we propose a deep-learning hybrid model called TensorGCN-LSTM based on the tensor data structure. The model treats SUs deployed at different spatial locations under the same frequency and the spectrum status of SUs themselves under different frequencies in the task area as nodes and constructs two types of graph structures. Graph convolutional operations are used to sequentially extract corresponding spatial-domain and frequency-domain features from the two types of graph structures. Then, the long short-term memory (LSTM) model is used to fuse the spatial, frequency, and temporal features of the cognitive radio environment data. Finally, the prediction task of the spectrum distribution situation is accomplished through fully connected layers. Specifically, the model constructs a tensor graph based on the spatial similarity of SUs' locations and the frequency correlation between different frequency signals received by SUs, which describes the electromagnetic wave's dependency relationship in spatial and frequency domains. LSTM is used to capture the electromagnetic wave's dependency relationship in the temporal domain. To evaluate the effectiveness of the model, we conducted ablation experiments on LSTM, GCN, GC-LSTM, and TensorGCN-LSTM models using simulated data. The experimental results show that our model achieved better prediction performance in RMSE, and the correlation coefficient R2 of 0.8753 also confirmed the feasibility of the model.
Optimal Protocols of Clinical and Genomic Data Collection for Prevention and Management of Congenital Anomalies
Authors: Jo Heui Seung , Yang Misun , Ahn So Yoon , Sung Se In , Park Won Soon , Jang Ja-Hyun , Chang Yun Sil
Published: August 2023

Standardized protocols were specifically designed and developed for clinical information collection and obtaining trio genomic information from infants affected with congenital anomalies (CA) and their parents, as well as securing human biological resources. Two large areas of these protocols include clinical and genomic information collection on CA which were difficult to diagnose using pre-existing screening methods. The following are three essential items for the clinical information collection protocol: establishment of a consent system for collecting and utilizing research resources, establishment of criteria for target patient selection, and collection of clinical and epidemiological information. A total of 138 cases consisting of 45 families of infants with CA and their parent trios have provided human-derived resources and genomic information. Whole genome sequencing data have been generated for all participants, and standardized protocols for resource collection and manufacturing have been developed. Phenotype information according to the Human Phenotype Ontology term and major test findings were recorded. It is important to keep updating and recording clinical symptoms and genetic diagnosis that are newly added or changed over time. The unique significance of this study is to develop a protocol that enables long-term tracking by adding growth and development tests that reflect important characteristics of newborns. By using these clinical and genetic information collection protocols for CA, it will be possible to establish an essential platform for early genetic diagnosis and diagnostic research, and further present new genetic diagnostic guidelines in the near future.
Investigating the Microwave-Assisted Extraction Conditions and Antioxidative and Anti-Inflammatory Capacities of Symphytum officinale WL Leaves
Authors: Lou Kuo-Hao , Tsai Ming-Shiun , Wu Jane-Yii
Published: August 2023

The root extracts of Symphytum officinale (comfrey) are commonly used in traditional medicine to treat muscle, joint, skin and bone disorders. However, little information is available on the biomedical functions of comfrey leaves. In this study, sequencing results of Internal Transcribed Spacer and trnL-trnF genes showed that plants purchased from the local market were comfrey and named as S. officinale WL (WL). The optimal extraction conditions of WL leave with the highest extract yield and contents of total phenols and flavonoids by microwave-assisted extraction were identified. The antioxidative and anti-inflammatory activities and possible molecular mechanism(s) of the WL leaf extract (WLE) were evaluated. Furthermore, the major component of WLE was identified as rosmarinic acid by HPLC. Results showed that the optimal extract condition was obtained with 750W microwave power, 50℃, 75% methanol, the solid-to-solvent ratio of 1:10, and 15 minutes. Results of all DPPH, ABTS and superoxide radical scavenging activities, reducing power, ferrous ion chelating activity, and ferric reducing antioxidant power showed high antioxidative capacities of WLE. Furthermore, WLE showed obvious DNA protecting activity. WLE attenuated lipopolysaccharides-stimulated inflammation by suppressing iNOS, COX-2, IL-1β, IL-6, and TNF-α expressions in RAW264.7 macrophages. These attenuations involved in inactivations of lipopolysaccharides-induced NF-κB and MAPK signaling pathways.
Extension of Fuzzy ELECTRE I for Evaluating Demand Forecasting Methods in Sustainable Manufacturing
Authors: Chu Ta-Chung , Nghiem Thi Bich Ha
Published: August 2023

The selectin of a demand forecasting method is critical for companies aiming to avoid manufacturing overproduction or shortages in pursuit of sustainable development. Various qualitative and quantitative criteria with different weights must be considered during the evaluation of a forecasting method. The qualitative criteria and criteria weights are usually assessed in linguistic terms. Aggregating these various criteria and linguistic weights for evaluating and selecting demand forecasting methods in sustainable manufacturing is a major challenge. This paper proposes an extension of fuzzy Elimination and Choice Translating Reality (ELECTRE) I to resolve this problem. In the proposed method, fuzzy weighted ratings are defuzzified with the signed distance to develop a crisp ELECTRE I model. Moreover, an extension to ELECTRE I is developed by suggesting an extended modified discordance matrix and a closeness coefficient for ranking alternatives. The proposed extension can overcome the problem of information loss which can lead to incorrect ranking result when using the Hadamard product to combine concordance and modified discordance matrices. A comparison is conducted to show the advantage of the proposed extension. Finally, a numerical example is used to demonstrate the feasibility of the proposed method; furthermore, a numerical comparison is made to display the advantage of the proposed method.
Research on Flesh Texture and Quality Traits upon Kiwifruit (cv. Xuxiang) at Fluctuating Temperatures during Cold Storage
Authors: Xu Ranran , Chen Qian , Zhang Yizhao , Li Jiali , Zhou Jiahua , Wang Yunxiang , Chang Hong , Meng Fanxiang , Wang Baogang
Published: August 2023

Kiwifruits are often exposed to various temperature fluctuation (TF) during postharvest storage. To evaluate the effect of TF on the qualities of kiwifruits, fruits were stored at 2 ºC, 2 ºC or 5 ºC (TF2ºC-5ºC), 2 ºC or 7 ºC (TF2ºC-7ºC), alternating every 12 h. Observations revealed that kiwifruits stored at constant 2 °C showed the lowest loss of weight and vitamin C due to the minimum ethylene production and respiratory rate compared to that of TF2ºC-5ºC and TF2ºC-7ºC. Moreover, the results of RT-qPCR verifed that the expression of genes encoding polygalacturonase, β-galacturonidase, and pectin methyl esterase was significantly increased by the treatment of TF. Hence, TF accelerated the degradation of the cell walls, softening, translucency and relative conductivity of the flesh of kiwifruits. Besides, the impact of TF2ºC-7ºC on kiwifruits was more significant relative to TF2ºC-5ºC. The present study provides a theoretical basis for kiwifruit during cold storage.
análise de falhas de um veículo off-road de competições universitárias do programa SAE Brasil
Authors: França Santos Ricardo , Arlochi de Oliveira Isabella , Souza Ferreira Luciane Caroline de , Perassoli da Silva Erick , Amorim Soares Macedo Felipe
Published: August 2023

Destaques: A FTA é uma técnica de confiabilidade que tem como objetivo identificar todas as combinações de causas que podem dar origem a um evento indesejado; estudar a probabilidade de ocorrência dessas causas e priorizar ações que visam impedir que essas causas ocorram e resultem no evento indesejado. A utilização do método possibilita a análise da confiabilidade de sistemas e também a construção da relação de causa−efeito de seus eventos, criando uma interface com a ferramenta FMEA. A FMEA é uma ferramenta de confiabilidade utilizada para encontrar possíveis falhas em um sistema, além de permitir a avaliação de suas possíveis consequências. Estes métodos e técnicas visam melhorar a confiabilidade de produtos ou processos, ou seja, aumentar a probabilidade de um item desempenhar sua função sem falhas. Objetivo: Analisar as falhas do sistema de suspensão de um veículo off-road de competição SAE utilizando as técnicas de análise do modo e efeito de falhas (FMEA) e de árvore de falhas (FTA), visando à melhoria da performance desses veículos em competições futuras. Desenho/Metodologia/Abordagem: Partiu-se pela definição do sistema de suspensão como objeto de estudo pelos pesquisadores junto à equipe de competição, seguido da coleta de informações e dados de falha deste sistema. Em seguida, foram utilizadas as ferramentas FMEA e FTA em paralelo a entrevistas realizadas com a equipe de competição. Resultados: Por meio da análise dos resultados constatou-se que as duas maiores probabilidades de falha estão relacionadas à suspensão e à manga do eixo com valores de 38,8% e 20,5%, respectivamente, e que o terminal rotular é o elemento mais crítico. Limitações da investigação: Ressalta-se como limitações desta pesquisa a subjetividade na atribuição de notas da FMEA devido à pouca experiência da equipe e ao reduzido histórico de documentação dos dados acerca de falhas do veículo relativas à dinâmica das competições da SAE. Implicações práticas: Como implicações práticas deste estudo vislumbra-se a possibilidade do aprimoramento profissional dos estudantes de engenharia pertencentes à equipe de competição. Originalidade/valor: Na busca na literatura verificou-se que o tema da pesquisa é original e, ao mesmo tempo, desafiador. Seus resultados permitirão reavaliar o projeto de construção do veículo Baja de competição.
Palavras-chave: FMEA; FTA, Programa Baja SAE Brasil; Sistema de Suspensão.
Interação medicamento-alimento: o que sabem os profissionais da farmácia e da nutrição?
Authors:   Universidade de Santiago, Sofia Dias Horta Silvânia , Filipe Ferreira Coelho André ,   H&TRC-Health & Technology Research Center, Escola Superior de Tecnologia da Saúde do Instituto Politécnico de Lisboa
Published: August 2023

INTRODUÇÃO: A interação medicamento-alimento/nutriente é um fenómeno, que merece uma atenta reflexão por parte dos profissionais de saúde, principalmente daqueles que na sua área de intervenção prescrevem, dispensam ou aconselham medicamentos e alimentos. É muito importante que esses profissionais, conheçam as particularidades (físico)-químicas dessas substâncias, para que assim, possam evitar possíveis interações entre elas, e consequentemente, garantir o sucesso terapêutico de cada doente. OBJETIVOS: Este estudo tem como objetivo caraterizar o conhecimento dos profissionais da saúde, nomeadamente nutricionistas e profissionais da área de farmácia, sobre interações entre medicamentos e alimentos. METODOLOGIA: Trata-se de um estudo qualitativo, recorrendo a um inquérito por questionário, enviado a profissionais de saúde que na sua área de intervenção se deparam com os riscos potenciais da interação entre medicamentos e alimentos. RESULTADOS E CONCLUSÕES: A análise dos resultados obtidos demonstra que os profissionais da área da farmácia, têm pouco conhecimento sobre as interações que podem ocorrer entre os medicamentos e os alimentos. Ainda que com algumas lacunas no conhecimento, os resultados indicam que os nutricionistas demonstram ter maior conhecimento sobre este tema. Considerando os resultados obtidos, e para otimizar o uso do medicamento, é importante desenvolver mecanismos que contribuam para aumentar o conhecimento dos profissionais de saúde sobre as interações entre medicamentos e alimentos.
Findings of Intravenous Gadolinium Inner Ear Magnetic Resonance Imaging in Patients With Acute Low-Tone Sensorineural Hearing Loss
Authors: Seo Hee Won , Kim Yikyung , Kim Hyung-Jin , Chung Won-Ho , Cho Young Sang
Published: August 2023

Objectives Acute low-tone sensorineural hearing loss (ALHL) is thought to have a different etiology from that of idiopathic sudden sensorineural hearing loss. We hypothesized that endolymphatic hydrops (EH) in the inner ear organ contributes to ALHL, even in patients without vertigo. This study investigated the presence of EH in ALHL and compared the clinical characteristics of patients with or without EH.Methods We retrospectively reviewed 38 patients diagnosed with ALHL without vertigo from January 2017 to March 2022. EH was measured in all patients using inner ear magnetic resonance imaging (MRI). In addition, we selected patients who showed only mid- or high-frequency hearing loss and had available MRI data as a control group and compared the ALHL and control groups.Results After treatment, the pure-tone average at low frequencies significantly improved compared to the initial hearing (P<0.001). Hearing recovery was observed in 63.1% of patients; however, the recovery rate did not differ based on the treatment method. During the follow-up period, six patients (15.8%) progressed to Meniere’s disease, and 18 (47.4%) experienced recurrence. In the ALHL group, the cochlear hydrops ratio on the affected side (0.34±0.09) was significantly higher than on the contralateral side (0.29±0.12) (P=0.005), and most patients showed hydrops in the apex area of the cochlea. Compared with the control group (0.25±0.15), the ALHL group showed a significantly higher cochlear hydrops ratio (P=0.043). The correlation analysis showed a tendency for hearing thresholds at low frequencies to increase as the hydrops ratio increased, albeit without statistical significance.Conclusion The cochlear hydrops ratio, especially in the apex area on the affected side, was significantly higher in patients with ALHL, suggesting that EH in the cochlea contributes to the pathogenesis of ALHL.
Differences in Clinical and Immunological Characteristics According to the Various Criteria for Tissue Eosinophilia in Chronic Rhinosinusitis With Nasal Polyps
Authors: Yang Seung Koo , Kim Jeong-Whun , Won Tae-Bin , Rhee Chae-Seo , Han Yeon Bi , Cho Sung-Woo
Published: August 2023

Objectives Several criteria exist for classifying chronic rhinosinusitis with nasal polyps (CRSwNP) as eosinophilic or non-eosinophilic. This study attempted to evaluate several criteria for defining eosinophilic CRSwNP from clinical and immunological perspectives.Methods A cohort of 84 patients (73 patients with CRSwNP and 11 control patients) was retrospectively analyzed. Patients were divided into eosinophilic and non-eosinophilic CRSwNP based on four different criteria: eosinophils (EOS) accounting for more than 20% of the total inflammatory cells; ≥70 EOS per high-power field (HPF); >55 EOS/HPF; and ≥10 EOS/HPF. Preoperative clinical characteristics, the immunological profiles of 14 cytokines from nasal tissue, and postoperative outcomes were compared between eosinophilic and non-eosinophilic CRSwNP based on each criterion. These criteria were immunologically validated by using 14 cytokines to predict the performance of tissue eosinophilia with a random forest model.Results Patients with eosinophilic CRSwNP were significantly older when the criterion of ≥10 EOS/HPF or EOS >20% was used. The number of patients with aspirin intolerance was significantly higher in eosinophilic CRSwNP based on the criterion of EOS >20%. From an immunological perspective, non-type 2 inflammatory cytokines were significantly higher in non-eosinophilic CRSwNP with the criterion of EOS >20% of the total inflammatory cells. In addition, the criterion of EOS >20% of the total inflammatory cells resulted in the best prediction of eosinophilic CRSwNP, with an accuracy of 88.10% and area under the curve of 0.94.Conclusion Clinical and immunological characteristics were different between eosinophilic and non-eosinophilic CRSwNP depending on a variety of criteria, and the results of this study should be taken into account when choosing the criterion for defining eosinophilic CRSwNP and interpreting the data accordingly.
Ultrasound-Guided Ethanol Percutaneous Ablation Versus Rescue Surgery in Patients With Locoregional Recurrence of Papillary Thyroid Cancer
Authors: Tofé Santiago , Argüelles Iñaki , Álvarez Cristina , Tofé Álvaro , Repetto Alessandra , Barceló Antonia , Pereg Vicente
Published: August 2023

Objectives Neck recurrence of papillary thyroid cancer (PTC) is frequently detected after initial surgery. The management of these lesions may include rescue surgery (RS) or minimally invasive techniques in selected patients, but comparative studies evaluating the effectiveness and safety of these techniques are lacking. In this paper, we compared ultrasound-guided ethanol ablation (EA) in selected patients to RS in a matched cohort.Methods We retrospectively compared 41 patients and 41 matched PTC patients without known distant metastases, who underwent ultrasound-guided EA or RS (matched reference group), who had 63 and 75 thyroid bed and/or lymph node confirmed PTC recurrences during a median follow-up of 72.8 and 89.6 months, respectively. The primary outcome was time until structural recurrence, compared using Kaplan-Meier survival curves. The secondary outcomes included time until biochemical recurrence, plasma thyroglobulin (Tg) levels, American Thyroid Association (ATA) response-to-therapy categories by the last available observation, and treatment-derived complications in each group.Results No significant differences were found between the EA and RS groups for time until structural recurrence (log-rank test, P=0.94). The time until biochemical recurrence was also similar (P=0.51); and the plasma Tg concentration reduction and proportions of patients in the ATA reclassification categories were also similar. A significantly higher proportion of patients in the RS group presented treatment-derived complications (29.27% vs. 9.75%, P<0.05).Conclusion In this retrospective analysis, the treatment of PTC neck recurrence with EA in selected patients was comparable to RS in a matched reference group for the long-term risk of structural or biochemical relapse, but with a lower risk of treatment-derived complications. These results support the effectiveness and safety of this minimally invasive technique in the management of selected patients with recurrent PTC.
Uluslararası Ticaretin Teknolojik Dizaynı: Uluslararası Dijital Tedarik Zinciri Örneği
Authors: BOŞGELMEZ Günseli , ÇENGEL Özgür
Published: August 2023

Ticaretin dijital dönüşümü, uluslararası tedarik zincirinde yeni düşünceleri ve yeni oluşumları zorunlu kılmaktadır. Dijital teknolojilerin yeni uygulamaları uluslararası ticaretin içerinde yepyeni ekosistemler oluşturuyor. Dünya ticaret hayatı dijital teknolojiler ile yeniden şekilleniyor, geleneksel iş yapma biçimleri kökten değişiyor uluslararası tedarik zinciri farklı bir teknolojik boyuta geçiyor. Bu çalışmada, uluslararası ticaretin yakın geleceğine bir hazırlık olması düşüncesiyle yeni teknolojilerin dizayn ettiği dijital ticaret sistemleri üzerine spesifik bir araştırma yapılmıştır. Çalışmanın amacı, dijital teknolojilerin uluslararası ticarete sunduğu yeni fırsatları ve katkıları tespit etmektir. Bu amaç doğrultusunda dijital ticaret işlemlerinden beklenen fayda, ticareti kolaylaştırması, teknolojiye güven ve yenilikler bağlamında tedarik zinciri üyelerinin görüşleri alınmıştır. Yarı yapılandırılmış görüşme formu ile yapılan görüşmelerden elde edilen nitel verilerin analizinden elde edilen bulgularla uluslararası ticaretin teknoloji ile olan yeni dizaynı daha güvenilir, daha kolay ve geleceğin daha da dijital olacağı öngörülmektedir.
Sokak Sağlıklaştırma Alanında Hazırlanan Tezlerin Bibliyometrik Analizi
Authors: ŞAHİN Esra , HALAÇ Hicran Hanım
Published: August 2023

1980’lerden bu yana uygulanmakta olan sokak sağlıklaştırması, özgünlüğünü kaybetmemiş olan tarihi kent yapı gruplarının onarımının/ iyileştirmesinin yapılmasıdır. Bu çalışmada Sokak Sağlıklaştırma konusuyla ilgili yapılan tezlerin bibliyometrik analiz yöntemiyle incelenmesi amaçlanmıştır. Çalışma konusu Ulusal Tez Merkezi’nde Sokak sağlıklaştırma, sokak iyileştirme, sokak rehabilitasyonu, cephe sağlıklaştırma, cephe iyileştirme ve cephe rehabilitasyonu olmak üzere altı farklı anahtar kelimenin tarama biçimi, aranacak alan, arama tipi şeklinde sınırlamalar getirilerek taranmıştır. Tez bulguları 01.04.2022- 11.04.2022 tarihinde elde edilmiştir. Veri bulguları 1991-2022 yıllarını kapsamaktadır. Toplamda elde edilen tez çalışması 210 adettir, çakışan tez çalışmaları çıkarıldığında ise 146 adettir. Konuyla bağlantısı olmayan çalışmalar ayrıştırıldığında ise 28 adet çalışmaya konu olan tez çalışması elde edilmiştir. İncelenen çalışmalar Microsoft Excel programında listelenmiş, grafik ve tablolara dönüştürülmüştür. Anahtar kelimeye göre tez türlerinde en çok cephe iyileştirme kelimesinde toplam 88 tez, yıllara göre tez türlerinde en çok 2019 yılı, tezlerde kullanılan kaynaklarda en çok kaynak kullanımı 673718 numaralı tez, tezlerin geçtiği konularda mimarlık, tezlerin yayınlandığı üniversitelerde 5 adetle en çok İstanbul Teknik Üniversitesi, tezlerin içinde yer alan anahtar kelimeler, tez konusu olan şehirler, tezlere danışmanlık yapılmış unvanlar, tezlerin çalışma alanı ve araştırma yöntemleri, tezlerdeki danışmanlık unvanları olmak üzere 10 farklı başlıkta değerlendirilmiştir. Çalışmanın daha sonraki yapılacak sokak sağlıklaştırma konulu araştırmalara katkı sağlanması istenmiştir.