bluuebunny/crossref_metadata_2025 huggingface dataset:
Image-level and group-level models for Drosophilagene expression pattern annotation
Authors: Sun Qian , Muckatira Sherin , Yuan Lei , Ji Shuiwang , Newfeld Stuart , Kumar Sudhir , Ye Jieping
Published: December 2013

Background

Drosophila melanogasterhas been established as a model organism for investigating the developmental gene interactions. The spatio-temporal gene expression patterns ofDrosophila melanogastercan be visualized byin situhybridization and documented as digital images. Automated and efficient tools for analyzing these expression images will provide biological insights into the gene functions, interactions, and networks. To facilitate pattern recognition and comparison, many web-based resources have been created to conduct comparative analysis based on the body part keywords and the associated images. With the fast accumulation of images from high-throughput techniques, manual inspection of images will impose a serious impediment on the pace of biological discovery. It is thus imperative to design an automated system for efficient image annotation and comparison.

Results

We present a computational framework to perform anatomical keywords annotation forDrosophilagene expression images. The spatial sparse coding approach is used to represent local patches of images in comparison with the well-known bag-of-words (BoW) method. Three pooling functions including max pooling, average pooling and Sqrt (square root of mean squared statistics) pooling are employed to transform the sparse codes to image features. Based on the constructed features, we develop both an image-level scheme and a group-level scheme to tackle the key challenges in annotatingDrosophilagene expression pattern images automatically. To deal with the imbalanced data distribution inherent in image annotation tasks, the undersampling method is applied together with majority vote. Results onDrosophilaembryonic expression pattern images verify the efficacy of our approach.

Conclusion

In our experiment, the three pooling functions perform comparably well in feature dimension reduction. The undersampling with majority vote is shown to be effective in tackling the problem of imbalanced data. Moreover, combining sparse coding and image-level scheme leads to consistent performance improvement in keywords annotation.
On a generalized diffusion equation arising in petroleum engineering
Authors: Al-Homidan Suliman , Ghanam Ryad A , Tatar Nasser-eddine
Published: December 2013

In this work we investigate a model which describes diffusion in petroleum engineering. The original model, which already generalizes the standard one (usual diffusion equation) to a non-local model taking into account the memory effects, is here further extended to cope with many other different possible situations. Namely, we consider the Hilfer fractional derivative which by its nature interpolates the Riemann-Liouville fractional derivative and the Caputo fractional derivative (the one that has been studied previously). At the same time, this kind of derivative provides us with a whole range of other types of fractional derivatives. We treat both the Neumann boundary conditions case and the Dirichlet boundary conditions case and find explicit solutions. In addition to that, we also discuss the case of an infinite reservoir.
Integrated molecular portrait of non-small cell lung cancers
Authors: Lazar Vladimir , Suo Chen , Orear Cedric , van den Oord Joost , Balogh Zsofia , Guegan Justine , Job Bastien , Meurice Guillaume , Ripoche Hugues , Calza Stefano , Hasmats Johanna , Lundeberg Joakim , Lacroix Ludovic , Vielh Philippe , Dufour Fabienne , Lehtiö Janne , Napieralski Rudolf , Eggermont Alexander , Schmitt Manfred , Cadranel Jacques , Besse Benjamin , Girard Philippe , Blackhall Fiona , Validire Pierre , Soria Jean-Charles , Dessen Philippe , Hansson Johan , Pawitan Yudi
Published: December 2013

Background

Non-small cell lung cancer (NSCLC), a leading cause of cancer deaths, represents a heterogeneous group of neoplasms, mostly comprising squamous cell carcinoma (SCC), adenocarcinoma (AC) and large-cell carcinoma (LCC). The objectives of this study were to utilize integrated genomic data including copy-number alteration, mRNA, microRNA expression and candidate-gene full sequencing data to characterize the molecular distinctions between AC and SCC.

Methods

Comparative genomic hybridization followed by mutational analysis, gene expression and miRNA microarray profiling were performed on 123 paired tumor and non-tumor tissue samples from patients with NSCLC.

Results

At DNA, mRNA and miRNA levels we could identify molecular markers that discriminated significantly between the various histopathological entities of NSCLC. We identified 34 genomic clusters using aCGH data; several genes exhibited a different profile of aberrations between AC and SCC, including PIK3CA, SOX2, THPO, TP63, PDGFB genes. Gene expression profiling analysis identified SPP1, CTHRC1and GREM1 as potential biomarkers for early diagnosis of the cancer, and SPINK1 and BMP7 to distinguish between AC and SCC in small biopsies or in blood samples. Using integrated genomics approach we found in recurrently altered regions a list of three potential driver genes, MRPS22, NDRG1 and RNF7, which were consistently over-expressed in amplified regions, had wide-spread correlation with an average of ~800 genes throughout the genome and highly associated with histological types. Using a network enrichment analysis, the targets of these potential drivers were seen to be involved in DNA replication, cell cycle, mismatch repair, p53 signalling pathway and other lung cancer related signalling pathways, and many immunological pathways. Furthermore, we also identified one potential driver miRNA hsa-miR-944.

Conclusions

Integrated molecular characterization of AC and SCC helped identify clinically relevant markers and potential drivers, which are recurrent and stable changes at DNA level that have functional implications at RNA level and have strong association with histological subtypes.
Concha bullosa mucocele with orbital invasion and secondary frontal sinusitis: a case report
Authors: Lee Jung-Hoon , Hong Sung-Lyong , Roh Hwan-Jung , Cho Kyu-Sup
Published: December 2013

Background

Although concha bullosa (CB) is the most common variants of the middle turbinate, mucocele of CB is uncommon. Furthermore, CB mucocele with orbital invasion and secondary frontal sinusitis has not been reported previously.

Case presentation

A 42-year-old Korean male presented with gradually progressive proptosis of right eye and right-sided frontal headache. He had previously undergone endoscopic sinus surgery (ESS) 15 and 9 years ago. The endoscopic examination showed an expansive, large middle turbinate with normal mucosa filled the majority of right nasal cavity and displaced the septum to the left. A computed tomography and magnetic resonance imaging showed a well demarcated cystic huge mass at right nasal cavity extending to ethmoid sinus and orbit. The mass caused a bony defect on the lamina papyracea and displaced medial rectus muscle and orbit laterally. Moreover, the right frontal and ethmoid sinus was totally opacified. This article reports orbital invasion and frontal sinusitis complicating a CB mucocele, which was successfully treated by endoscopic resection of the lateral wall of CB and frontal sinusotomy.

Conclusions

This case illustrates that CB mucocele could develop to such a massive extent that it leads to orbital complication and secondary frontal sinusitis. Therefore, we consider this entity in the differential diagnosis of orbital complications and secondary sinusitis caused by intranasal mass.
The measurement of tissue interface pressures and changes in jugular venous parameters associated with cervical immobilisation devices: a systematic review
Authors: Sparke Alison , Voss Sarah , Benger Jonathan
Published: December 2013

Cervical immobilisation is commonly applied following trauma, particularly blunt head injury, but current methods of immobilisation are associated with significant complications. Semi-rigid disposable cervical collars are known to cause pressure ulcers, and impede effective airway management. These collars may also exacerbate a head injury by increasing intracranial pressure as a result of external compression of the jugular veins. There is a clear imperative to find ways of effectively immobilising the cervical spine whilst minimising complications, and any assessment of existing or new devices should include a standardized approach to the measurement of tissue interface pressures and their effect on jugular venous drainage from the brain. This systematic review summarises the research methods and technologies that have been used to measure tissue interface pressure and assess the jugular vein in the context of cervical immobilisation devices. 27 papers were included and assessed for quality. Laboratory investigations and biomechanical studies have gradually given way to methods that more accurately reflect clinical care. There are numerous accounts of skin ulceration associated with cervical collars, but no standardised approach to measuring tissue interface pressure. It is therefore difficult to compare studies and devices, but a pressure of less than 30 mmHg appears desirable. Cervical collars have been shown to have a compressive effect on the jugular veins, but it is not yet certain that this is the cause of the increased intracranial pressure observed in association with cervical collar use. This is the first review of its type. It will help guide further research in this area of trauma care, and the development and testing of new cervical immobilisation devices.
Soluble antigen traffics rapidly and selectively from the corneal surface to the eye draining lymph node and activates T cells when codelivered with CpG oligonucleotides
Authors: Dang Zexu , Kuffová Lucia , Liu Lei , Forrester John V
Published: December 2013

The transport of antigen to the secondary lymphoid tissue is a central component in the initiation of the adaptive immune response. The mechanism of antigen delivery to the DLN from the avascular cornea has not been fully explored. Previous studies in the mouse have shown that cell-associated corneal antigen is delivered within 6 h to the eye draining SM DLN via DCs and macrophages. In this study, we used a system in which antigen and the processed p-MHCII complexes derived from the antigen could be tracked in vivo. We report that soluble antigen applied to an abraded cornea in the mouse is transported rapidly (within 30 min) to the SM DLN, where a proportion is taken up by resident DCs and presented as p-MHCII complexes, while the larger part is cleared by 8 h. At a later time, a second wave of antigen transport in migratory DCs enters the DLN and participates in further continued antigen presentation. With the use of an antigen-specific TCR transgenic mouse system, we demonstrate that T cell activation does not occur during the early stages of soluble antigen delivery to LN, even though p-MHCII complexes are generated. Antigen-specific T cell activation occurs in the later, presumed cell-associated phase but requires codelivery of a “danger” signal, such as the TLR ligand CpG. We suggest that the early delivery of soluble antigen is more likely to induce T cell nonresponsiveness (anergy) unless presented in the context of an innate-immune cell activation (danger) signal.
Incidence of New Primary Melanomas After Diagnosis of Stage III and IV Melanoma
Authors: Zimmer Lisa , Haydu Lauren E. , Menzies Alexander M. , Scolyer Richard A. , Kefford Richard F. , Thompson John F. , Schadendorf Dirk , Long Georgina V.
Published: December 2013

Purpose

New primary melanomas (NPMs) have developed in some patients with metastatic melanoma treated with BRAF inhibitors. We sought to determine the background incidence of spontaneous NPMs after a diagnosis of American Joint Committee on Cancer/International Union Against Cancer stage III or IV melanoma in patients not treated with a BRAF inhibitor.

Patients and Methods

Patients diagnosed with stage III or IV melanoma at Melanoma Institute Australia between 1983 and 2008 were analyzed, and those who received a BRAF inhibitor were excluded.

Results

Two hundred twenty-nine (5%) of 4,215 patients with stage III melanoma and 43 (1%) of 3,563 patients with stage IV melanoma had at least one NPM after diagnosis of stage III or IV disease. The 6-month, 1-year, and 10-year cumulative incidence rates of developing an NPM after stage III melanoma were 1.2% (95% CI, 0.86% to 1.51%), 1.8% (95% CI, 1.44% to 2.26%), and 5.9% (95% CI, 5.08% to 6.74%), respectively. The 3-month, 6-month, and 1-year cumulative incidence rates of NPM after diagnosis of stage IV melanoma were 0.2% (95% CI, 0.07% to 0.36%), 0.3% (95% CI, 0.15% to 0.51%), and 0.4% (95% CI, 0.25% to 0.7%), respectively. In both patients with stage III and stage IV melanoma, male patients and patients with a prior history of multiple primaries had a higher incidence of NPM.

Conclusion

Patients with stage III and stage IV melanoma remain at risk for development of further primary melanomas, particularly if they have a history of multiple primary melanomas before stage III or IV disease. The incidence rates are lower than those reported in patients receiving BRAF inhibitors. However, the results must be compared with caution because dermatologic assessment is more frequent in BRAF inhibitor trials.
TMPRSS2:ERG Gene Fusion Predicts Subsequent Detection of Prostate Cancer in Patients With High-Grade Prostatic Intraepithelial Neoplasia
Authors: Park Kyung , Dalton James T. , Narayanan Ramesh , Barbieri Christopher E. , Hancock Michael L. , Bostwick David G. , Steiner Mitchell S. , Rubin Mark A.
Published: December 2013

Purpose

High-grade prostatic intraepithelial neoplasia (HGPIN) is considered a precursor lesion of prostate cancer (PCa). The predictive value of ERG gene fusion in HGPIN for PCa was interrogated as a post hoc analysis in the context of a randomized clinical trial.

Patients and Methods

The GTx Protocol G300104 randomly assigned 1,590 men with biopsy-diagnosed HGPIN to receive toremifene or placebo for 3 years or until a diagnosis of PCa was made on prostate biopsy. As part of this phase III clinical trial, a central pathologist evaluated biopsies of patients with isolated HGPIN at baseline and 12, 24, and 36 months of follow-up. ERG immunohistochemistry was performed on biopsies from 461 patients and evaluated for protein overexpression.

Results

ERG expression was detected in 11.1% of patients (51 of 461 patients) with isolated HGPIN. In the first year and during the 3-year clinical trial, 14.7% and 36.9% of 461 patients were diagnosed with PCa, respectively. Patients with ERG expression were more likely to develop PCa, with 27 (53%) of 51 ERG-positive and 143 (35%) of 410 ERG-negative patients experiencing progression to PCa (P = .014, Fisher's exact test). ERG expression was not associated with age, baseline PSA, Gleason score, or tumor volume.

Conclusion

This study underscores the necessity of more stringent follow-up for men with HGPIN that is also positive for ERG overexpression. Clinicians should consider molecular characterization of HGPIN as a means to improve risk stratification.
Fractionated 90Y-Ibritumomab Tiuxetan Radioimmunotherapy As an Initial Therapy of Follicular Lymphoma: An International Phase II Study in Patients Requiring Treatment According to GELF/BNLI Criteria
Authors: Illidge Tim M. , Mayes Sam , Pettengell Ruth , Bates Andrew T. , Bayne Mike , Radford John A. , Ryder W. David J. , Le Gouill Steven , Jardin Fabrice , Tipping Jill , Zivanovic Maureen , Kraeber-Bodere Françoise , Bardies Manuel , Bodet-Milin Caroline , Malek Emmanuel , Huglo Damien , Morschhauser Franck
Published: December 2013

Purpose

We report an international, multicenter phase II trial to evaluate the efficacy and toxicity of fractionated 90Y-ibritumomab tiuxetan (90Y-IT) as initial therapy of follicular lymphoma (FL).

Patients and Methods

A total of 74 patients, with a median age of 61 years (range, 28 to 80 years), were recruited requiring initial therapy by Groupe d'Etude des Lymphomes Folliculaires (GELF)/British National Lymphoma Investigation (BNLI) criteria. Among them, 78% had stage III-IV disease, 32% intermediate, and 44% high-risk (according to FL International Prognostic Index). Treatment consisted of two doses of 90Y-IT (11.1 MBq/kg) administered 8 to 12 weeks apart. Patients with more than 20% lymphoma infiltration of bone marrow (BM) received one infusion per week for 4 consecutive weeks of rituximab (375 mg/m2) and proceeded to fractionated radioimmunotherapy (RIT) only if a repeat BM biopsy demonstrated clearing of lymphoma to less than 20% involvement. The primary end point was end of treatment response of the intention-to-treat population. Secondary objectives were safety and progression-free survival (PFS).

Results

Initial overall response rate (ORR) was 94.4% (68 of 72 patients) with combined complete response (CR/CRu) of 58.3% (42 of 72 patients). Nine patients subsequently improved response making an ORR of 95.8% (69 of 72 patients) and CR/CRu of 69.4% (50 of 72 patients). At a median follow-up of 3.1 years (range, 0.2 to 5.2 years) estimated 3-year PFS is 58%, treatment-free survival 66%, and overall survival 95%. Median PFS is 40.2 months. Thirty patients have experienced disease progression and 24 have required further treatment. The treatment was well tolerated with few (2.8%) grade 3 or 4 infectious episodes or adverse events and manageable hematologic toxicity.

Conclusion

Fractionated RIT using 90Y-IT is an effective initial treatment for advanced-stage FL in patients with higher tumor burden requiring treatment.
Randomized Phase III Trial of Temsirolimus Versus Sorafenib As Second-Line Therapy After Sunitinib in Patients With Metastatic Renal Cell Carcinoma
Authors: Hutson Thomas E. , Escudier Bernard , Esteban Emilio , Bjarnason Georg A. , Lim Ho Yeong , Pittman Kenneth B. , Senico Peggy , Niethammer Andreas , Lu Dongrui Ray , Hariharan Subramanian , Motzer Robert J.
Published: December 2013

Purpose

This international phase III trial (Investigating Torisel As Second-Line Therapy [INTORSECT]) compared the efficacy of temsirolimus (mammalian target of rapamycin inhibitor) and sorafenib (vascular endothelial growth factor receptor [VEGFR] tyrosine kinase inhibitor) as second-line therapy in patients with metastatic renal cell carcinoma (mRCC) after disease progression on sunitinib.

Patients and Methods

In total, 512 patients were randomly assigned 1:1 to receive intravenous temsirolimus 25 mg once weekly (n = 259) or oral sorafenib 400 mg twice per day (n = 253), with stratification according to duration of prior sunitinib therapy (≤ or > 180 days), prognostic risk, histology (clear cell or non–clear cell), and nephrectomy status. The primary end point was progression-free survival (PFS) by independent review committee assessment. Safety, objective response rate (ORR), and overall survival (OS) were secondary end points.

Results

Primary analysis revealed no significant difference between treatment arms for PFS (stratified hazard ratio [HR], 0.87; 95% CI, 0.71 to 1.07; two-sided P = .19) or ORR. Median PFS in the temsirolimus and sorafenib arms were 4.3 and 3.9 months, respectively. There was a significant OS difference in favor of sorafenib (stratified HR, 1.31; 95% CI, 1.05 to 1.63; two-sided P = .01). Median OS in the temsirolimus and sorafenib arms was 12.3 and 16.6 months, respectively. Safety profiles of both agents were consistent with previous studies.

Conclusion

In patients with mRCC and progression on sunitinib, second-line temsirolimus did not demonstrate a PFS advantage compared with sorafenib. The longer OS observed with sorafenib suggests sequenced VEGFR inhibition may benefit patients with mRCC.
Randomized Phase III Trial of Temsirolimus and Bevacizumab Versus Interferon Alfa and Bevacizumab in Metastatic Renal Cell Carcinoma: INTORACT Trial
Authors: Rini Brian I. , Bellmunt Joaquim , Clancy Jill , Wang Kongming , Niethammer Andreas G. , Hariharan Subramanian , Escudier Bernard
Published: December 2013

Purpose

To prospectively determine the efficacy of combination therapy with temsirolimus plus bevacizumab versus interferon alfa (IFN) plus bevacizumab in metastatic renal cell carcinoma (mRCC).

Patients and Methods

In a randomized, open-label, multicenter, phase III study, patients with previously untreated predominantly clear-cell mRCC were randomly assigned, stratified by prior nephrectomy and Memorial Sloan-Kettering Cancer Center prognostic group, to receive the combination of either temsirolimus (25 mg intravenously, weekly) or IFN (9 MIU subcutaneously thrice weekly) with bevacizumab (10 mg/kg intravenously, every 2 weeks). The primary end point was independently assessed progression-free survival (PFS).

Results

Median PFS in patients treated with temsirolimus/bevacizumab (n = 400) versus IFN/bevacizumab (n = 391) was 9.1 and 9.3 months, respectively (hazard ratio [HR], 1.1; 95% CI, 0.9 to 1.3; P = .8). There were no significant differences in overall survival (25.8 ν 25.5 months; HR, 1.0; P = .6) or objective response rate (27.0% ν 27.4%) with temsirolimus/bevacizumab versus IFN/bevacizumab, respectively. Patients receiving temsirolimus/bevacizumab reported significantly higher overall mean scores in the Functional Assessment of Cancer Therapy–Kidney Symptom Index (FKSI) –15 and FKSI-Disease Related Symptoms subscale compared with IFN/bevacizumab (indicating improvement); however, no differences in global health outcome measures were observed. Treatment-emergent all-causality grade ≥ 3 adverse events more common (P < .001) with temsirolimus/bevacizumab were mucosal inflammation, stomatitis, hypophosphatemia, hyperglycemia, and hypercholesterolemia, whereas neutropenia was more common with IFN/bevacizumab. Incidence of pneumonitis with temsirolimus/bevacizumab was 4.8%, mostly grade 1 or 2.

Conclusion

Temsirolimus/bevacizumab combination therapy was not superior to IFN/bevacizumab for first-line treatment in clear-cell mRCC.
Minireview: Role Of Orphan Nuclear Receptors in Cancer and Potential as Drug Targets
Authors: Safe Stephen , Jin Un-Ho , Hedrick Erik , Reeder Alexandra , Lee Syng-Ook
Published: December 2013

The nuclear orphan receptors for which endogenous ligands have not been identified include nuclear receptor (NR)0B1 (adrenal hypoplasia congenita critical region on chromosome X gene), NR0B2 (small heterodimer partner), NR1D1/2 (Rev-Erbα/β), NR2C1 (testicular receptor 2), NR2C2 (testicular receptor 4), NR2E1 (tailless), NR2E3 (photoreceptor-specific NR [PNR]), NR2F1 chicken ovalbumin upstream promoter transcription factor 1 (COUP-TFI), NR2F2 (COUP-TFII), NR2F6 (v-erbA-related protein), NR4A1 (Nur77), NR4A2 (Nurr1), NR4A3 (Nor1), and NR6A1 (GCNF). These receptors play essential roles in development, cellular homeostasis, and disease including cancer where over- or underexpression of some receptors has prognostic significance for patient survival. Results of receptor knockdown or overexpression in vivo and in cancer cell lines demonstrate that orphan receptors exhibit tumor-specific pro-oncogenic or tumor suppressor-like activity. For example, COUP-TFII expression is both a positive (ovarian) and negative (prostate and breast) prognostic factor for cancer patients; in contrast, the prognostic activity of adrenal hypoplasia congenita critical region on chromosome X gene for the same tumors is the inverse of COUP-TFII. Functional studies show that Nur77 is tumor suppressor like in acute leukemia, whereas silencing Nur77 in pancreatic, colon, lung, lymphoma, melanoma, cervical, ovarian, gastric, and some breast cancer cell lines induces one or more of several responses including growth inhibition and decreased survival, migration, and invasion. Although endogenous ligands for the orphan receptors have not been identified, there is increasing evidence that different structural classes of compounds activate, inactivate, and directly bind several orphan receptors. Thus, the screening and development of selective orphan receptor modulators will have important clinical applications as novel mechanism-based agents for treating cancer patients overexpressing one or more orphan receptors and also for combined drug therapies.
A new role for the calcineurin/NFAT pathway in neonatal myosin heavy chain expression via the NFATc2/MyoD complex during mouse myogenesis
Authors: Daou Nissrine , Lecolle Sylvie , Lefebvre Suzie , Gaspera Bruno della , Charbonnier Frédéric , Chanoine Christophe , Armand Anne-Sophie
Published: December 2013

The calcineurin/NFAT (nuclear factor of activated T-cells) signaling pathway is involved in the modulation of the adult muscle fiber type, but its role in the establishment of the muscle phenotype remains elusive. Here, we show that the NFAT member NFATc2 cooperates with the basic helix-loop-helix transcription factor MyoD to induce the expression of a specific myosin heavy chain (MHC) isoform, the neonatal one, during embryogenesis. We found this cooperation to be crucial, as Myod/Nfatc2 double-null mice die at birth, with a dramatic reduction of the major neonatal MHC isoform normally expressed at birth in skeletal muscles, such as limb and intercostal muscles, whereas its expression is unaffected in myofibers mutated for either factor alone. Using gel shift and chromatin immunoprecipitation assays, we identified NFATc2 bound to the neonatal Mhc gene, whereas NFATc1 and NFATc3 would preferentially bind the embryonic Mhc gene. We provide evidence that MyoD synergistically cooperates with NFATc2 at the neonatal Mhc promoter. Altogether, our findings demonstrate that the calcineurin/NFAT pathway plays a new role in establishing the early muscle fiber type in immature myofibers during embryogenesis.
Mechanisms of scaling in pattern formation
Authors: Umulis David M. , Othmer Hans G.
Published: December 2013

Many organisms and their constituent tissues and organs vary substantially in size but differ little in morphology; they appear to be scaled versions of a common template or pattern. Such scaling involves adjusting the intrinsic scale of spatial patterns of gene expression that are set up during development to the size of the system. Identifying the mechanisms that regulate scaling of patterns at the tissue, organ and organism level during development is a longstanding challenge in biology, but recent molecular-level data and mathematical modeling have shed light on scaling mechanisms in several systems, including Drosophila and Xenopus. Here, we investigate the underlying principles needed for understanding the mechanisms that can produce scale invariance in spatial pattern formation and discuss examples of systems that scale during development.
Gas Chromatography-Mass Spectrometric Studies of O-Alkyl O-2-(N,N-Dialkylamino) Ethyl Alkylphosphonites(Phosphonates) for Chemical Weapons Convention Verification
Authors: Saeidian Hamid , Babri Mehran , Ramezani Atefeh , Ashrafi Davood , Sarabadani Mansour , Naseri Mohammad Taghi
Published: December 2013

The electron ionization (EI) mass spectra of a series of O-alkyl O-2-( N,N-dialkylamino)ethyl alkylphosphonites(phosphonates), which are precursors of nerve agents, were studied for Chemical Weapons Convention (CWC) verification. General EI fragmentation pathways were constructed and discussed. Proposed fragment structures were confirmed through analyzing fragment ions of deuterated analogs and density functional theory (DFT) calculations. The observed fragment ions are due to different fragmentation pathways such as hydrogen and McLafferty+1 rearrangements, alkene, amine and alkoxy elimination by α- or β-cleavage process. Fragment ions distinctly allow unequivocal identification of the interested compounds including those of isomeric compounds. The presence and abundance of fragment ions were found to depend on the size and structure of the alkyl group attached to nitrogen, phosphorus and oxygen atoms.
H2 Unimolecular Elimination in Electrospray Ionization Mass Spectrometry from Erythraline, a Spirocyclic Alkaloid
Authors: Silva Denise Brentan , Guaratini Thais , Vessecchi Ricardo , Lopes Norberto Peporine , Cramer Benedikt , Humpf Hans-Ulrich , Lopes João Luis Callegari
Published: December 2013

Erythrina alkaloids, which contain a spirocyclic structure, are well known due to their important biological activity at the central nervous system. In this study, systematic electrospray ionization tandem mass spectrometry (ESI-MS/MS) and ESI-multistage mass spectrometry (MS n) analysis of erythraline have shown an unexpected H2 neutral elimination reaction. We have investigated the formation of these ions by accurate-mass ESI-MS/MS with different analyzers and the data suggest a possible unimolecular reaction of H2 loss.
A Preliminary Study of Arecoline and Guvacoline Presence in the Saliva of a “Betel-Quid” Chewer Using Liquid-Chromatography Ion Trap Mass Spectrometry
Authors: Kadi Adnan A. , Attwa Mohamed W. , Rahman A.F.M. Motiur
Published: December 2013

It has been reported that the parasympathomimetic alkaloid arecoline and the nootropic agent guvacoline have been detected in areca nut ( Areca catechu L.) during extraction using a basic medium. Here, we have studied the detection of arecoline and guvacoline in vivo in saliva of a “betel-quid” chewer using liquid-chromatography ion trap mass spectrometry. In this paper, we provide evidence that guvacoline is absent in the neutral aqueous extract of betel nut, but is present in abundance in the aqueous extract with added lime (pH 11.9). In an in vivo experiment, we demonstrated that guvacoline is present in the salivary extracts in the mouth with lime (pH 9.5) and without lime (pH 5.3).
Influence of Electrolytes and a Supercharging Reagent on Charge State Distribution and Response of Neuropeptide Ions Generated during Positive Electrospray Ionisation Mass Spectrometry
Authors: Nielsen Birthe V. , Abaye Daniel A.
Published: December 2013

To aid in the detection of trace quantities of neuropeptides in a biological matrix (as saliva), the influence of different electrolytes and a supercharging reagent on the positive electrospray ionisation mass spectrometry (ESI-MS) response was investigated. Ammonium acetate, sodium chloride and sodium bicarbonate (10−7 M to 10−3 M) and the supercharging reagent m-nitrobenzyl alcohol ( m-NBA) was added to the mobile phase and the effect on the ESI response and charge-states distribution (CSD) was studied in a group of peptides (molecular weight range 2.2 kDa to 3.5 kDa; CGRP, VIP, GLP1, CRF and PrRP). As expected, the result indicates that the ESI response is affected by the presence of additives: ammonium acetate shifted the observed charge states ratio whereas the addition of m-NBA resulted in the appearance of higher maximum charge state ions. This increase in higher charge state for all the peptide ions, [M + nH] n+ to [M + ( n + 1)H] n+1, was atttributed to protonation of the C-terminal. However, when the composition of MeCN in a mobile phase containing m-NBA was increased, an enhancement of the total ion signal was observed for non-polar peptide samples. This is a very interesting observation as this is not observed in samples without m-NBA and could be a result of how these peptide ions are solubilised and positioned relative to the droplet surface/air interface.
ΑΛΓΟΡΙΘΜΟΙ ΔΙΑΜΕΛΙΣΜΟΥ ΓΡΑΜΜΙΚΗΣ ΕΚΤΙΜΗΣΗΣ-ΣΥΓΚΡΙΤΙΚΗ ΥΠΟΛΟΓΙΣΤΙΚΗ ΑΝΑΛΥΣΗ
Authors: Αναγνώστου Κωνσταντίνος
Published: December 2013

Η ΔΙΑΤΡΙΒΗ ΑΥΤΗ ΔΙΑΠΡΑΓΜΑΤΕΥΕΤΑΙ ΑΛΓΟΡΙΘΜΟΥΣ ΔΙΑΜΕΛΙΣΜΟΥ ΓΡΑΜΜΙΚΗΣ ΕΚΤΙΜΗΣΗΣ ΓΙΑ ΣΥΣΤΗΜΑΤΑ ΔΙΑΚΡΙΤΟΥ ΧΡΟΝΟΥ. ΚΑΤ' ΑΡΧΗΝ ΠΑΡΟΥΣΙΑΖΟΝΤΑΙ ΤΕΣΣΕΡΙΣ ΝΕΟΙ ΑΝΑΔΡΟΜΙΚΟΙ ΑΛΓΟΡΙΘΜΟΙ ΔΙΑΜΕΛΙΣΜΟΥ ΑΝΑ ΔΕΙΓΜΑ ΓΡΑΜΜΙΚΗΣ ΕΚΤΙΜΗΣΗΣ. ΣΤΗ ΣΥΝΕΧΕΙΑ ΓΙΝΕΤΑΙ ΣΥΓΚΡΙΤΙΚΗ ΥΠΟΛΟΓΙΣΤΙΚΗ ΑΝΑΛΥΣΗ ΤΩΝ ΝΕΩΝ ΑΥΤΩΝ ΑΛΓΟΡΙΘΜΩΝ, ΜΕ ΤΡΕΙΣ ΑΛΛΟΥΣ ΑΛΓΟΡΙΘΜΟΥΣ ΔΙΑΜΕΛΙΣΜΟΥ (ΤΟ ΓΕΝΙΚΕΥΜΕΝΟ ΑΛΓΟΡΙΘΜΟ ΔΙΑΜΕΛΙΣΜΟΥ ΤΟΥ ΛΑΙΝΙΩΤΗ, ΤΟΝ ΑΝΑΔΡΟΜΙΚΟ ΑΛΓΟΡΙΘΜΟ ΔΙΑΜΕΛΙΣΜΟΥ ΤΩΝ ANDRISANI, GUA ΚΑΙ ΤΟ ΓΡΑΜΜΙΚΟ ΦΙΛΤΡΟ ΔΙΑΜΕΛΙΣΜΟΥ ΑΝΑ ΔΕΙΓΜΑ ΤΟΥ ΛΑΙΝΙΩΤΗ) ΚΑΙ ΜΕ ΤΟΝ ΑΛΓΟΡΙΘΜΟ (ΦΙΛΤΡΟ) KALMAN, ΣΧΕΤΙΚΑ ΜΕ ΤΙΣ ΥΠΟΛΟΓΙΣΤΙΚΕΣ ΤΩΝ ΑΠΑΙΤΗΣΕΙΣ ΑΠΟΘΗΚΕΥΣΗΣ ΚΑΙ ΧΡΟΝΟΥ, ΤΟΣΟ ΓΙΑ ΧΡΟΝΙΚΑ ΑΜΕΤΑΒΛΗΤΑ ΟΣΟ ΚΑΙ ΓΙΑ ΧΡΟΝΙΚΑ ΜΕΤΑΒΑΛΛΟΜΕΝΑ ΜΟΝΤΕΛΑ. ΤΕΛΟΣ ΟΙ ΟΙΚΟΝΟΜΙΚΟΤΕΡΟΙ (ΑΠΟ ΑΠΟΨΗ ΑΠΑΙΤΗΣΕΩΝ ΑΠΟΘΗΚΕΥΣΗΣ) ΚΑΙ ΤΑΧΥΤΕΡΟΙ ΑΠΟ ΤΟΥΣ ΑΛΓΟΡΙΘΜΟΥΣ ΑΥΤΟΥΣ, ΕΦΑΡΜΟΖΟΝΤΑΙ ΣΤΟ ΠΡΑΚΤΙΚΟ ΠΡΟΒΛΗΜΑ ΤΗΣ ΕΚΤΙΜΗΣΗΣ ΤΩΝ ΠΟΛΛΩΝ ΑΙΣΘΗΤΗΡΩΝ.
ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ ΤΗΣ ΓΛΥΚΟΖΟΑΙΜΟΣΦΑΙΡΙΝΗΣ (CT- 6) ΚΑΙ ΤΗΣ ΚΑΜΠΥΛΗΣ ΓΛΥΚΟΖΗΣ (OGTT) ΣΕ ΦΥΣΙΟΛΟΓΙΚΕΣ ΚΑΙ ΠΑΘΟΛΟΓΙΚΕΣ ΚΑΤΑΣΤΑΣΕΙΣ
Authors: Χαβιάρας Βασίλης
Published: December 2013

Στην παρούσα εργασία έγινε σύγκριση μεταξύ τών καμπύλων ανοχής στή γλυκόζη (OGTT) καί της γλυκοζοαιμοσφαιρίνης (G-Hb) σέ 64 άτομα από τά οποία τά 27 μέ φυσιολογική καί τά 37 μέ παθολογική καμπύλη γλυκόζης, μέ σκοπό τήν πιθανή χρησιμοποίηση της G-Hb γιά τήν διάγνωση καί τήν παρακολούθηση τοϋ διαβήτη. Ή G-Hb μετρήθηκε χρωματογραφικώς καί ήλεκτροφορητικώς. Ή σύγκριση τών δύο μεθόδων έδειξε ότι ή χρωματογραφία είναι προτιμότερη γιά λόγους οικονομίας, ταχύτητας, ακριβείας καί έπαναληψιμότητας. Ή σύγκριση τών OGTT μεταξύ τών φυσιολογικών ανδρών καί γυναικών δέν παρουσίασε σημαντική διαφορά. Σέ 17 διαβητικούς ασθενείς έχορηγεϊτο έπί τρεις εβδομάδες άναστολεύς της α-γλυκοζιτάσης σέ μιά προσπάθεια περιορισμού της αφομοίωσης των υδατανθράκων άπό τό έντερο. Σέ αντίθεση μέ τόν σημαντικό περιορισμό τών επιπέδων της γλυκόζης μετά τήν θεραπεία, ή μεταβολή της G-Hb υπήρξε ασήμαντη, οφειλόμενη στον μικρό χρόνο της θεραπείας σέ σχέση μέ τόν χρόνο ζωής τών έρυθροκυττάρων. Ή μεταβολή της G-Hb στά διάφορα στάδια της καμπύλης ανοχής στην γλυκόζη υπήρξε ασήμαντη, όπως πολύ μικρή υπήρξε ή διαφορά της G-Hb σέ αντίθεση μέ τήν μεταβολή της OGTT στην διάρκεια της θεραπείας μέ αναστολείς της α-γλυκοσιτάσης 17 διαβητικών ασθενών έπί τρεις εβδομάδες. Ή συσχέτιση της G-Hb μέ τήν γλυκόζη στην κορυφή της καμπύλης της OGTT υπήρξε πολύ σημαντική (r=+0,83), μέ συνέπεια ή G-Hb νά μπορεί νά συναγωνισθή με τήν καμπύλη ανοχής στην γλυκόζη σάν ένα πιό απλό, πιό εύκολο καί πιό ταχύ κριτήριο διαβητικού έλεγχου, προς όφελος της επιστήμης καί των ασθενών.
ΜΕΛΕΤΗ ΠΑΝΩ ΣΤΗΝ ΠΕΡΙΒΑΛΛΟΝΤΙΚΗ ΜΕΘΥΛΙΩΣΗ ΤΩΝ ΜΕΤΑΛΛΩΝ ΥΔΡΑΡΓΥΡΟΥ, ΚΑΣΙΤΕΡΟΥ ΚΑΙ ΜΟΛΥΒΔΟΥ ΣΕ ΥΔΑΤΙΚΑ ΟΙΚΟΣΥΣΤΗΜΑΤΑ
Authors: Χατζησπύρου Σπύρος
Published: December 2013

ΣΚΟΠΟΣ ΤΗΣ ΜΕΛΕΤΗΣ ΑΥΤΗΣ ΗΤΑΝ Η ΕΡΕΥΝΑ ΤΩΝ ΣΥΝΘΗΚΩΝ, ΚΑΤΩ ΑΠΟ ΤΙΣ ΟΠΟΙΕΣ ΣΥΜΒΑΙΝΕΙ ΜΕΤΑΦΟΡΑ ΟΜΑΔΩΝ ΜΕΘΥΛΙΟΥ ΣΕ ΜΟΡΦΕΣ ΜΕΤΑΛΛΩΝ, ΚΑΙ ΣΥΓΚΕΚΡΙΜΕΝΑ ΣΕ HG, SN ΚΑΙ PB ΣΤΟ ΠΕΡΙΒΑΛΛΟΝ.
ΠΡΟΒΛΗΜΑΤΑ ΑΓΩΓΗΣ ΥΓΕΙΑΣ ΣΕ ΠΛΗΘΥΣΜΟ ΣΧΟΛΙΚΗΣ ΗΛΙΚΙΑΣ
Authors: Βελονάκης Εμμανουήλ
Published: December 2013

ΣΤΗ ΜΕΛΕΤΗ ΑΥΤΗ ΓΙΝΕΤΑΙ ΜΙΑ ΠΡΟΣΠΑΘΕΙΑ ΑΠΟΤΥΠΩΣΗΣ ΤΗΣ ΣΧΟΛΙΚΗΣ ΕΚΠΑΙΔΕΥΣΗΣ ΥΓΕΙΑΣ ΣΤΗ ΧΩΡΑ ΜΑΣ. Η ΣΧΟΛΙΚΗ ΕΚΠΑΙΔΕΥΣΗ ΥΓΕΙΑΣ ΠΑΡΕΧΕΤΑΙ ΚΥΡΙΑ ΑΠΟ ΤΑ ΦΥΣΙΟΓΝΩΣΤΙΚΑ ΜΑΘΗΜΑΤΑ ΤΗΣ ΣΤΟΙΧΕΙΩΔΟΥΣ ΕΚΠΑΙΔΕΥΣΗΣ ΚΑΙ ΤΑ ΜΑΘΗΜΑΤΑ ΒΙΟΛΟΓΙΑΣ ΚΑΙ ΥΓΙΕΙΝΗΣ ΤΗΣ ΜΕΣΗΣ ΕΚΠΑΙΔΕΥΣΗΣ. ΤΑ ΜΑΘΗΜΑΤΑ ΑΥΤΑ ΔΙΔΑΣΚΟΝΤΑΙ ΤΙΣ ΤΕΛΕΥΤΑΙΕΣ ΣΥΝΗΘΩΣ ΩΡΕΣ ΤΗΣ ΗΜΕΡΑΣ ΙΔΙΑΙΤΕΡΑ ΣΤΑ ΛΥΚΕΙΑ. Η ΔΙΔΑΣΚΑΛΙΑ ΤΟΥΣ ΣΥΝΗΘΩΣ ΔΕΝ ΕΜΠΛΟΥΤΙΖΕΤΑΙ ΜΕ ΕΠΟΠΤΙΚΑ ΜΕΣΑ ΕΙΤΕ ΕΠΕΙΔΗ ΔΕΝ ΥΠΑΡΧΟΥΝ ΣΤΑ ΣΧΟΛΕΙΑ, ΕΙΤΕ ΕΠΕΙΔΗ ΟΤΑΝΥΠΑΡΧΟΥΝ ΔΕΝ ΧΡΗΣΙΜΟΠΟΙΟΥΝΤΑΙ ΕΠΑΡΚΩΣ. Ο ΡΟΛΟΣ ΤΗΣ ΕΚΠΑΙΔΕΥΤΙΚΗΣ ΤΗΛΕΟΡΑΣΗΣ ΕΙΝΑΙ ΠΕΡΙΟΡΙΣΜΕΝΟΣ, ΔΙΟΤΙ ΔΕΝ ΕΙΝΑΙ ΟΛΑ ΤΑ ΣΧΟΛΕΙΑ ΕΦΟΔΙΑΣΜΕΝΑ ΜΕ ΤΗΛΕΟΠΤΙΚΟΥΣ ΔΕΙΚΤΕΣ. Η ΒΑΘΜΟΛΟΓΙΑ ΣΤΑ "ΜΑΘΗΜΑΤΑ ΥΓΕΙΑΣ" ΔΕΝ ΒΑΣΙΖΕΤΑΙ ΣΤΗΝ ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΣΤΑΣΕΩΝ ΤΩΝ ΜΑΘΗΤΩΝ, ΟΥΤΕ ΤΩΝ ΙΔΙΑΙΤΕΡΩΝ ΤΟΥΣ, ΑΛΛΑ ΣΤΗΝ ΑΠΟΜΝΗΜΟΝΕΥΣΗ ΣΥΓΚΕΚΡΙΜΕΝΩΝ ΠΛΗΡΟΦΟΡΙΩΝ. Η ΒΑΘΜΟΛΟΓΙΑ ΣΤΑ ΜΑΘΗΜΑΤΑ ΑΥΤΑ ΕΙΝΑΙ ΑΡΚΕΤΑ ΥΨΗΛΗ ΣΥΜΒΑΛΛΟΝΤΑΣ ΣΤΗ ΔΙΑΜΟΡΦΩΣΗ ΥΨΗΛΩΝ ΓΕΝΙΚΩΝ ΜΕΣΩΝ ΟΡΩΝ, ΕΞΑΛΛΟΥ ΑΥΞΑΝΕΙ ΤΟ ΛΥΚΕΙΟ ΩΣΑΠΟΤΕΛΕΣΜΑ ΤΗΣ ΑΥΞΗΜΕΝΗΣ ΔΥΝΑΤΟΤΗΤΑΣ ΤΩΝ ΜΑΘΗΤΩΝ ΝΑ ΑΠΟΜΝΗΜΟΝΕΥΟΥΝ ΤΙΣ ΠΛΗΡΟΦΟΡΙΕΣ ΠΟΥ ΠΑΡΕΧΟΥΝ ΤΑ "ΜΑΘΗΜΑΤΑ ΥΓΕΙΑΣ". Η ΜΕΓΑΛΥΤΕΡΗ ΣΥΣΧΕΤΙΣΗ ΤΗΣ ΒΑΘΜΟΛΟΓΙΑΣ ΜΕΤΑΞΥ "ΜΑΘΗΜΑΤΩΝ ΥΓΕΙΑΣ" ΚΑΙ ΘΕΤΙΚΩΝ ΜΑΘΗΜΑΤΩΝ ΣΥΓΚΡΙΤΙΚΑ ΜΕ ΑΥΤΗ ΜΕΤΑΞΥ "ΜΑΘΗΜΑΤΩΝ ΥΓΕΙΑΣ" ΚΑΙ ΘΕΩΡΗΤΙΚΩΝ ΜΑΘΗΜΑΤΩΝ, ΠΟΥ ΥΠΑΡΧΕΙ ΣΤΟ ΓΥΜΝΑΣΙΟ, ΑΝΤΙΣΤΡΕΦΕΤΑΙ ΣΤΟ ΛΥΚΕΙΟ. ΜΕ ΤΗ ΣΥΜΠΛΗΡΩΣΗ ΕΙΔΙΚΟΥ ΕΡΩΤΗΜΑΤΟΛΟΓΙΟΥ ΔΕΙΧΘΗΚΕ ΟΤΙ ΟΙ ΜΑΘΗΤΕΣ ΑΠΑΙΤΟΥΝ ΣΩΣΤΑ ΚΑΙ ΜΕ ΑΚΡΙΒΕΙΑ ΠΕΡΙΣΣΟΤΕΡΟ ΣΕ ΕΡΩΤΗΣΕΙΣ ΠΟΥ ΕΧΟΥΝ ΔΙΔΑΧΘΕΙ ΚΑΙ ΣΕ ΘΕΜΑΤΑ ΥΓΙΕΙΝΗΣ ΣΥΓΚΡΙΤΙΚΑ ΜΕ ΘΕΜΑΤΑ ΑΝΑΤΟΜΙΑΣ, ΦΥΣΙΟΛΟΓΙΑΣ 'Η ΝΟΣΟΛΟΓΙΑΣ. ΤΟ ΕΠΙΠΕΔΟ ΤΩΝ ΓΝΩΣΕΩΝ ΤΩΝ ΜΑΘΗΤΩΝ ΕΞΑΡΤΑΤΑΙ ΑΠΟ ΚΟΙΝΩΝΙΚΟΟΙΚΟΝΟΜΙΚΟΥΣ ΠΑΡΑΓΟΝΤΕΣ ΟΠΩΣ ΤΟ ΜΕΓΕΘΟΣ ΤΗΣ ΟΙΚΟΓΕΝΕΙΑΣ, ΤΟ ΕΠΑΓΓΕΛΜΑ ΚΑΙ ΤΟ ΜΟΡΦΩΤΙΚΟ ΕΠΙΠΕΔΟ ΤΩΝ ΓΟΝΕΩΝ.
ΔΙΑΜΑΧΕΣ ΕΛΛΗΝΩΝ ΚΑΙ ΑΡΜΕΝΙΩΝ ΓΙΑ ΤΑ ΠΡΟΣΚΥΝΗΜΑΤΑ ΤΩΝ ΑΓΙΩΝ ΤΟΠΩΝ
Authors: Γκαγκανιάρας Δαμασκηνός
Published: December 2013

ΤΟ ΠΑΤΡΙΑΡΧΕΙΟΝ ΙΕΡΟΣΟΛΥΜΩΝ ΜΕΣΑ ΣΤΑ 1500 ΧΡΟΝΙΑ ΙΣΤΟΡΙΑΣ ΤΟΥ ΑΓΩΝΙΣΘΗΚΕ ΜΕ ΜΕΓΑΛΗ ΔΥΝΑΜΗ ΕΝΑΝΤΙΟΝ ΤΩΝ ΑΛΛΩΝ ΧΡΙΣΤΙΑΝΙΚΩΝ ΔΟΓΜΑΤΩΝ ΑΡΜΕΝΙΩΝ ΚΑΙ ΦΡΑΓΚΩΝ ΜΕ ΣΚΟΠΟ ΝΑ ΜΕΙΝΟΥΝ ΤΑ ΠΑΝΑΓΙΑ ΠΡΟΣΚΥΝΗΜΑΤΑ ΣΤΑ ΧΕΡΙΑ ΤΩΝ ΕΛΛΗΝΩΝ ΟΡΘΟΔΟΞΩΝ. ΟΙ ΑΡΜΕΝΙΟΙ ΠΡΟΣΠΑΘΗΣΑΝ ΜΕ ΟΛΑ ΤΑ ΟΡΘΟΔΟΞΑ ΚΑΙ ΜΗ ΟΡΘΟΔΟΞΑ ΜΕΤΡΑ ΝΑ ΕΚΤΟΠΙΣΟΥΝ ΤΟΥΣΕΛΛΗΝΕΣ ΚΑΙ ΝΑ ΓΙΝΟΥΝ ΑΥΤΟΙ ΚΥΡΙΟΙ ΤΩΝ ΠΑΝΑΓΙΩΝ ΠΡΟΣΚΥΝΗΜΑΤΩΝ. ΕΠΕΤΥΧΑΝ ΤΟΝ ΣΚΟΠΟ ΤΟΥΣ ΜΕΡΙΚΩΣ ΚΑΙ ΕΓΙΝΑΝ "ΣΥΓΚΙΟΝΟΝΟΙ" ΜΕ ΤΟΥΣ ΕΛΛΗΝΕΣ ΚΑΙ ΤΟΥΣ ΦΡΑΓΚΟΥΣ. ΟΙ ΕΛΛΗΝΕΣ ΚΑΤΟΡΘΩΣΑΝ ΝΑ ΠΑΡΑΜΕΙΝΟΥΝ ΚΥΡΙΟΙ ΤΩΝ ΠΑΝΑΓΙΩΝ ΠΡΟΣΚΥΝΗΜΑΤΩΝ ΜΕ ΠΟΛΥ ΛΙΓΕΣ ΑΠΩΛΕΙΕΣ.
ΘΕΩΡΙΑ ΤΟΥ ΠΙΝΑΚΑ ΣΚΕΔΑΣΗΣ ΓΙΑ ΘΕΡΜΟΕΛΑΣΤΙΚΑ ΚΥΜΑΤΑ
Authors: Καθρέπτας Νικόλαος
Published: December 2013

ΣΕ ΑΥΤΗ ΤΗ ΔΙΑΤΡΙΒΗ ΑΝΑΠΤΥΣΣΕΤΑΙ Η ΜΕΘΟΔΟΣ ΑΝΑΠΑΡΑΣΤΑΣΗΣ ΤΟΥ ΤΕΛΕΣΤΗ ΣΚΕΔΑΣΗΣ ΤΩΝ ΘΕΡΜΟΕΛΑΣΤΙΚΩΝ ΚΥΜΑΤΩΝ ΜΕ ΠΙΝΑΚΑ. Η ΣΚΕΔΑΣΗ ΘΕΩΡΕΙΤΑΙ ΣΕ ΙΣΟΤΡΟΠΑ, ΟΜΟΓΕΝΗ, ΓΡΑΜΜΙΚΑ, ΕΛΑΣΤΙΚΑ ΚΑΙ ΘΕΡΜΙΚΑ ΑΓΩΓΙΜΑ ΥΛΙΚΑ. Ο ΠΙΝΑΚΑΣ ΣΚΕΔΑΣΗΣ (T-MATRIX) ΣΥΝΔΙΑΖΕΙ ΤΟΥΣ ΣΥΝΤΕΛΕΣΤΕΣ ΤΟΥ ΠΡΟΣΠΙΠΤΟΝΤΟΣ ΚΥΜΑΤΟΣ ΠΡΟΣ ΤΟΥΣ ΣΥΝΤΕΛΕΣΤΕΣ ΤΟΥΣΚΕΔΑΣΜΕΝΟΥ ΚΥΜΑΤΟΣ ΚΑΙ ΕΞΑΡΤΑΤΑΙ ΜΟΝΟ ΑΠΟ ΤΗ ΓΕΩΜΕΤΡΙΑ ΚΑΙ ΤΟ ΥΛΙΚΟ ΤΟΥ ΣΚΕΔΑΣΤΗ. Ο ΦΟΡΜΑΛΙΣΜΟΣ ΠΟΥ ΑΚΟΛΟΥΘΕΙΤΑΙ, ΧΩΡΙΖΕΤΑΙ ΣΕ ΤΡΙΑ ΜΕΡΗ. ΣΤΟ ΠΡΩΤΟ ΔΙΔΟΝΤΑΙ ΟΙ ΒΑΣΙΚΕΣ ΕΞΙΣΩΣΕΙΣ ΤΗΣ ΘΕΡΜΟΕΛΑΣΤΙΚΟΤΗΤΑΣ ΚΑΙ ΣΤΟ ΔΕΥΤΕΡΟ ΜΕΡΟΣ ΕΞΑΓΟΝΤΑΙΟΛΟΚΛΗΡΩΤΙΚΕΣ ΑΝΑΠΑΡΑΣΤΑΣΕΙΣ ΓΙΑ ΤΑ ΟΛΙΚΑ ΠΕΔΙΑ ΤΩΝ ΜΕΤΑΤΟΠΙΣΕΩΝ ΚΑΙ ΤΗΣ ΘΕΡΜΟΚΡΑΣΙΑΣ. ΜΕ ΒΑΣΗ ΑΥΤΕΣ ΤΙΣ ΟΛΟΚΛΗΡΩΤΙΚΕΣ ΑΝΑΠΑΡΑΣΤΑΣΕΙΣ, ΣΤΟ ΤΡΙΤΟ ΜΕΡΟΣ ΔΙΔΕΤΑΙ Η ΜΕΘΟΔΟΛΟΓΙΑ ΚΑΤΑΣΚΕΥΗΣ ΤΟΥ ΠΙΝΑΚΑ ΣΚΕΔΑΣΗΣ. ΤΑ ΣΤΟΙΧΕΙΑ ΤΟΥ ΠΙΝΑΚΑ ΕΙΝΑΙ ΕΠΙΦΑΝΕΙΑΚΑ ΟΛΟΚΛΗΡΩΜΑΤΑ ΠΑΝΩ ΣΤΗΝ ΕΠΙΦΑΝΕΙΑ ΤΟΥ ΣΚΕΔΑΣΤΗ ΚΑΙ ΜΠΟΡΟΥΝ ΝΑ ΥΠΟΛΟΓΙΣΤΟΥΝ ΑΡΙΘΜΗΤΙΚΑ. Ο ΙΔΙΟΣ ΠΙΝΑΚΑΣ ΜΠΟΡΕΙ ΝΑ ΧΡΗΣΙΜΟΠΟΙΗΘΕΙ ΓΙΑ ΚΑΘΕ ΕΙΔΟΥΣΑΡΜΟΝΙΚΗ ΠΡΟΣΠΤΩΣΗ ΚΑΙ ΓΙΑ ΤΥΧΟΥΣΑ ΓΕΩΜΕΤΡΙΚΗ ΜΟΡΦΗ ΤΟΥ ΣΚΕΔΑΣΤΗ.
Ενδομυελική εφαρμογή δύο ήλων Ender's εις κατάγματα κνήμης
Authors: Παζαρίδης Στέφανος
Published: December 2013

ΧΡΗΣΙΜΟΠΟΙΗΣΑΜΕ 2 ΗΛΟΥΣ ENDER'S ΣΕ ΚΑΤΑΓΜΑΤΑ ΚΝΗΜΗΣ ΣΕ 57 ΑΣΘΕΝΕΙΣ ΜΕ 59 ΚΑΤΑΓΜΑΤΑ ΑΦΟΥ ΠΡΟΗΓΟΥΜΕΝΩΣ ΕΙΧΕ ΓΙΝΕΙ ΠΕΙΡΑΜΑΤΙΚΗ ΔΟΚΙΜΗ ΣΕ ΠΤΩΜΑΤΙΚΕΣ ΚΝΗΜΕΣ ΣΤΟ ΤΜΗΜΑ ΑΝΤΟΧΗΣ ΥΛΙΚΩΝ ΤΟΥ ΕΘΝΙΚΟΥ ΜΕΤΣΟΒΙΟΥ ΠΟΛΥΤΕΧΝΕΙΟΥ. Ο ΜΕΣΟΣ ΧΡΟΝΟΣ ΠΟΡΩΣΕΩΣ ΗΤΑΝ 3,13 ΜΗΝΕΣ ΜΕ ΑΡΙΣΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΣΕ 48 ΚΑΤΑΓΜΑΤΑ, ΠΟΛΥ ΚΑΛΟ ΣΕ 6, ΚΑΛΑ ΣΕ 4 ΚΑΙ ΚΑΚΑ ΣΕ 1 ΚΑΤΑΓΜΑ. Η ΜΕΛΕΤΗ ΑΠΟΤΕΛΕΙΤΑΙ ΑΠΟ 4 ΚΕΦΑΛΑΙΑ: 1ΟΝ ΙΣΤΟΡΙΚΗ ΑΝΑΣΚΟΠΗΣΙΣ ΑΝΑΤΟΜΙΚΗ ΑΓΓΕΙΩΣΙΣ, ΠΟΡΩΣΙΣ. 2ΟΝ ΗΛΟΙ ENDER'S ΚΑΙ ΑΝΤΟΧΗ ΤΟΥΣ. 3ΟΝ ΕΝΔΕΙΞΕΙΣ, ΠΡΟΕΓΧΕΙΡΗΤΙΚΗ ΕΤΟΙΜΑΣΙΑ ΚΑΙ ΤΕΧΝΙΚΗ ΜΕ ΤΙΣ ΕΠΙΠΛΟΚΕΣ ΤΗΣ. 4ΟΝ ΑΝΑΛΥΤΙΚΗ ΠΑΡΟΥΣΙΑΣΗ ΤΩΝ ΠΕΡΙΠΤΩΣΕΩΝ-ΣΥΖΗΤΗΣΗ.
ΑΝΑΛΥΣΗ ΕΓΧΕΙΡΙΔΙΩΝ ΞΕΝΩΝ ΓΛΩΣΣΩΝ ΚΑΙ ΑΞΙΟΛΟΓΗΣΗ ΤΟΥΣ ΩΣ ΠΡΟΣ ΤΗΝ ΚΑΤΑΛΛΗΛΟΤΗΤΑΓΙΑ ΕΠΙΔΙΩΞΗ ΕΠΙΚΟΙΝΩΝΙΑΚΩΝ ΣΤΟΧΩΝ
Authors: Τσοπάνογλου Αντώνιος
Published: December 2013

ΣΤΗ ΔΙΑΤΡΙΒΗ ΑΥΤΗ ΔΙΑΤΥΠΩΝΕΤΑΙ ΑΠΟ ΤΟ ΣΥΝΤΑΚΤΗ ΤΗΣ ΕΝΑ ΝΕΟ ΜΟΝΤΕΛΟ ΑΝΑΛΥΣΗΣ ΔΙΔΑΚΤΙΚΟΥ ΥΛΙΚΟΥ, ΤΟ ΟΠΟΙΟ ΒΑΣΙΖΕΤΑΙ ΣΤΗΝ ΠΑΙΔΑΓΩΓΙΚΗ ΘΕΩΡΙΑ ΤΟΥ "CURRICULUM" ΚΑΙΠΙΟ ΣΥΓΚΕΚΡΙΜΕΝΑ ΣΤΟΝ ΚΛΑΔΟ ΠΟΥ ΕΙΝΑΙ ΓΝΩΣΤΟΣ ΜΕ ΤΟΝ ΟΡΟ "ΤΑΞΙΝΟΜΙΕΣ ΣΤΟΧΩΝ". ΤΟ ΜΟΝΤΕΛΟ ΑΥΤΟ ΕΠΙΤΡΕΠΕΙ ΑΦΕΝΟΣ ΤΗΝ ΑΝΙΧΝΕΥΣΗ ΤΟΥ ΕΙΔΙΚΟΥ ΣΤΟΧΟΥ ΠΟΥ ΕΠΙΔΙΩΚΕΤΑΙ ΣΕ ΚΑΘΕ ΔΙΔΑΚΤΙΚΗ ΚΑΙ ΜΑΘΗΣΙΑΚΗ ΔΡΑΣΤΗΡΙΟΤΗΤΑ ΕΝΟΣ ΕΓΧΕΙΡΙΔΙΟΥ 'Η ΑΛΛΟΥ ΔΙΔΑΚΤΙΚΟΥ ΥΛΙΚΟΥ ΑΦΕΤΕΡΟΥ ΤΗΝ ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΕΓΧΕΙΡΙΔΙΩΝ ΩΣ ΠΡΟΣ ΕΝΑ ΣΥΓΚΕΚΡΙΜΕΝΟ ΧΑΡΑΚΤΗΡΙΣΤΙΚΟ ΤΟΥΣ. ΕΚΤΟΣ ΑΠΟ ΤΗΝ ΠΕΡΙΓΡΑΦΗ ΤΟΥ ΜΟΝΤΕΛΟΥ ΣΤΗ ΔΙΑΤΡΙΒΗ ΓΙΝΕΤΑΙ ΚΑΙ ΠΑΡΟΥΣΙΑΣΗ ΤΩΝ ΠΟΡΙΣΜΑΤΩΝ ΕΡΕΥΝΑΣ ΠΟΥ ΕΙΧΕ ΣΑΝ ΣΤΟΧΟ ΤΗΝ ΕΦΑΡΜΟΓΗ ΤΟΥ ΜΟΝΤΕΛΟΥ ΚΑΙ ΤΟΝ ΕΛΕΓΧΟ ΤΗΣ ΑΠΟΔΟΣΗΣ ΤΟΥ. ΣΤΗΝ ΕΡΕΥΝΑ ΑΥΤΗ ΑΝΑΛΥΘΗΚΑΝ ΚΑΙ ΑΞΙΟΛΟΓΗΘΗΚΑΝ 7 ΕΓΧΕΙΡΙΔΙΑ ΓΙΑ ΔΙΔΑΣΚΑΛΙΑ ΤΗΣ ΑΓΓΛΙΚΗΣ, ΤΗΣ ΓΑΛΛΙΚΗΣ ΚΑΙ ΤΗΣ ΙΤΑΛΙΚΗΣ. ΣΤΗΝ ΕΡΕΥΝΑ ΠΗΡΑΝ ΜΕΡΟΣ 272 ΦΟΙΤΗΤΕΣ, ΚΥΡΙΩΣ ΤΩΝ ΤΜΗΜΑΤΩΝ ΓΑΛΛΙΚΗΣ ΚΑΙ ΙΤΑΛΙΚΗΣ ΓΛ. ΚΑΙ ΦΙΛΟΛΟΓΙΑΣ ΤΟΥ Α.Π.Θ., ΟΙ ΟΠΟΙΟΙ ΧΡΗΣΙΜΕΥΣΑΝ ΩΣ "ΚΡΙΤΕΣ" ΓΙΑ ΤΗΝ ΚΑΤΗΓΟΡΙΟΠΟΙΗΣΗ ΤΟΥ ΔΙΔΑΚΤΙΚΟΥ ΥΛΙΚΟΥ ΤΩΝ ΠΡΩΤΩΝ "ΕΝΟΤΗΤΩΝ" ΚΑΘΕ ΕΓΧΕΙΡΙΔΙΟΥ.
Πειραματική διερεύνηση διατμητικής συμπεριφοράς ασυνεχειών βράχου με υλικό πληρώσεως
Authors: Μανωλοπούλου-Παπαλιάγκα Στέλλα
Published: December 2013

Η ΠΑΡΟΥΣΑ ΕΡΓΑΣΙΑ ΕΙΝΑΙ ΜΙΑ ΠΕΙΡΑΜΑΤΙΚΗ ΠΡΟΣΕΓΓΙΣΗ ΤΟΥ ΠΡΟΒΛΗΜΑΤΟΣ ΤΗΣ ΔΙΑΤΜΗΤΙΚΗΣ ΣΥΜΠΕΡΙΦΟΡΑΣ ΑΣΥΝΕΧΕΙΩΝ ΒΡΑΧΟΥ ΜΕ ΥΛΙΚΟ ΠΛΗΡΩΣΕΩΣ. ΣΑΝ ΔΟΚΙΜΙΑ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΟΜΟΙΩΜΑΤΑ ΦΥΣΙΚΩΝ ΤΡΑΧΕΙΩΝ ΑΣΥΝΕΧΕΙΩΝ ΑΠΟ ΕΙΔΙΚΟ ΤΣΙΜΕΝΤΟΚΟΝΙΑΜΑ ΤΟΥ ΟΠΟΙΟΥ ΟΙ ΙΔΙΟΤΗΤΕΣ ΣΕ ΦΥΣΙΚΗ ΚΛΙΜΑΚΑ ΑΝΤΙΠΡΟΣΩΠΕΥΟΥΝ ΕΝΑ ΧΟΝΔΡΟΚΟΚΚΟ ΒΡΑΧΟ ΜΕΣΗΣ ΘΛΙΠΤΙΚΗΣ ΑΝΤΟΧΗΣ. ΤΑ ΟΜΟΙΩΜΑΤΑ ΑΥΤΑ ΥΠΟΒΛΗΘΗΚΑΝ ΣΕ ΔΟΚΙΜΕΣ ΑΜΕΣΗΣ ΔΙΑΤΜΗΣΗΣ ΣΕ ΕΝΑ ΕΥΡΟΣ ΟΡΘΩΝ ΤΑΣΕΩΝ ΠΟΥ ΑΝΤΙΣΤΟΙΧΕΙ ΣΤΑ ΠΕΡΙΣΣΟΤΕΡΑ ΕΡΓΑ ΠΟΛΙΤΙΚΟΥ ΜΗΧΑΝΙΚΟΥ. ΣΑΝ ΥΛΙΚΑ ΠΛΗΡΩΣΕΩΣ ΕΠΙΛΕΧΤΗΚΑΝ ΕΝΑ ΑΝΤΙΠΡΟΣΩΠΕΥΤΙΚΟ ΨΑΘΥΡΟ ΥΛΙΚΟ ΜΕ ΓΩΝΙΩΔΕΙΣ ΚΟΚΚΟΥΣ (ΜΑΡΜΑΡΟΣΚΟΝΗ) ΚΑΙ ΕΝΑ ΑΣΘΕΝΕΣ ΠΛΑΣΤΙΚΟ ΑΡΓΙΛΙΚΟ ΥΛΙΚΟ (ΚΑΟΛΙΝΗΣ). ΜΕΛΕΤΑΤΑΙ ΧΩΡΙΣΤΑ Η ΕΠΙΔΡΑΣΗ ΠΟΥ ΑΣΚΕΙ ΤΟ ΠΑΧΟΣ ΤΩΝ ΥΛΙΚΩΝ ΑΥΤΩΝ, Η ΤΡΑΧΥΤΗΤΑ ΤΩΝΤΟΙΧΩΜΑΤΩΝ ΚΑΙ Η ΟΡΘΗ ΤΑΣΗ ΣΤΗ ΔΙΑΤΜΗΤΙΚΗ ΑΝΤΟΧΗ ΚΑΙ ΠΑΡΑΜΟΡΦΩΣΙΜΟΤΗΤΑ ΤΩΝ ΑΣΥΝΕΧΕΙΩΝ. ΕΞΕΤΑΖΕΤΑΙ ΕΠΙΣΗΣ Η ΜΟΡΦΗ ΚΑΙ Η ΘΕΣΗ ΤΩΝ ΕΠΙΦΑΝΕΙΩΝ ΑΣΤΟΧΙΑΣ ΚΑΘΩΣ ΚΑΙΗ ΕΚΤΑΣΗ ΚΑΙ ΚΑΤΑΝΟΜΗ ΤΩΝ ΕΠΙΦΑΝΕΙΩΝ ΕΠΑΦΗΣ ΤΩΝ ΤΟΙΧΩΜΑΤΩΝ. ΠΡΟΣΔΙΟΡΙΖΕΤΑΙ ΓΙΑΚΑΘΕ ΠΕΡΙΠΤΩΣΗ Η ΚΡΙΣΙΜΗ ΤΙΜΗ ΤΟΥ ΠΑΧΟΥΣ ΤΟΥ ΥΛΙΚΟΥ ΠΛΗΡΩΣΕΩΣ, ΠΕΡΑΝ ΑΠΟ ΤΗΝ ΟΠΟΙΑ ΔΕΝ ΥΠΑΡΧΕΙ ΠΕΡΑΙΤΕΡΩ ΜΕΤΑΒΟΛΗ ΤΗΣ ΔΙΑΤΜΗΤΙΚΗΣ ΑΝΤΟΧΗΣ. ΤΕΛΟΣ, ΜΕ ΒΑΣΗ ΤΑ ΠΕΙΡΑΜΑΤΙΚΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΗΣ ΠΑΡΟΥΣΑΣ ΕΡΕΥΝΗΤΙΚΗΣ ΕΡΓΑΣΙΑΣ, ΠΡΟΤΕΙΝΕΤΑΙ ΕΝΑ ΑΠΛΟ ΜΑΘΗΜΑΤΙΚΟ ΠΡΟΣΟΜΟΙΩΜΑ ΓΙΑ ΤΗΝ ΠΡΟΒΛΕΨΗ ΤΗΣ ΔΙΑΤΜΗΤΙΚΗΣ ΑΠΟΧΗΣ ΑΣΥΝΕΧΕΙΩΝ ΒΡΑΧΟΥ ΜΕ ΥΛΙΚΟ ΠΛΗΡΩΣΕΩΣ.
ΜΕΛΕΤΗ ΤΗΣ ΚΥΚΛΟΦΟΡΙΑΣ ΤΩΝ ΥΔΑΤΩΝ ΣΕ ΛΙΜΝΕΣ. ΕΦΑΡΜΟΓΗ ΣΤΗ ΛΙΜΝΗ ΤΡΙΧΩΝΙΔΑ
Authors: Ζαχαρίας Ιερόθεος
Published: December 2013

ΜΕ ΤΙΣ ΠΟΙΚΙΛΕΣ ΠΑΡΕΜΒΑΣΕΙΣ ΤΟΥ ΑΝΘΡΩΠΟΥ ΣΤΗ ΦΥΣΗ, ΤΑ ΥΔΑΤΙΝΑ ΟΙΚΟΣΥΣΤΗΜΑΤΑ ΥΠΟΒΑΘΜΙΖΟΝΤΑΙ ΚΑΙ ΜΕΤΑΤΡΕΠΟΝΤΑΙ ΣΕ ΠΕΡΙΒΑΛΛΟΝΤΑ ΜΟΛΥΝΣΗΣ. ΣΤΗΝ ΑΝΤΙΜΕΤΩΠΙΣΗ ΤΩΝ ΠΡΟΒΛΗΜΑΤΩΝ ΡΥΠΑΝΣΗΣ ΕΙΝΑΙ ΑΠΑΡΑΙΤΗΤΗ Η ΓΝΩΣΗ ΤΗΣ ΔΥΝΑΜΙΚΗΣ ΣΥΜΠΕΡΙΦΟΡΑΣ ΤΟΥΣ. Η ΥΔΡΟΔΥΝΑΜΙΚΗ ΣΥΜΠΕΡΙΦΟΡΑ ΕΝΟΣ ΟΙΚΟΣΥΣΤΗΜΑΤΟΣ ΜΠΟΡΕΙ ΝΑ ΑΠΟΚΤΗΘΕΙ ΜΕ ΜΕΤΡΗΣΕΙΣ ΣΤΟ ΦΥΣΙΚΟ ΠΕΔΙΟ, ΑΛΛΑ ΚΑΙ ΜΕ ΤΗ ΔΟΜΗΣΗ ΑΡΙΘΜΗΤΙΚΩΝ ΜΟΝΤΕΛΩΝ ΠΟΥ ΘΑ ΒΟΗΘΗΣΟΥΝ ΤΗΝ ΚΑΤΑΝΟΗΣΗ ΤΩΝ ΔΙΕΡΓΑΣΙΩΝ ΠΟΥ ΣΥΜΒΑΙΝΟΥΝ ΣΤΗ ΦΥΣΗ. Η ΕΡΓΑΣΙΑ ΑΥΤΗΠΑΡΟΥΣΙΑΖΕΙ ΜΙΑ ΠΕΡΙΕΚΤΙΚΗ ΚΑΙ ΣΥΓΧΡΟΝΗ ΑΠΟΨΗ ΤΗΣ ΕΠΙΣΤΗΜΗΣ ΤΗΣ ΛΙΜΝΟΛΟΓΙΑΣ.ΔΟΘΗΚΕ ΕΜΦΑΣΗ ΣΤΟΝ ΤΡΟΠΟ ΔΕΙΓΜΑΤΟΛΗΨΙΑΣ, ΕΠΕΞΕΡΓΑΣΙΑΣ ΔΕΔΟΜΕΝΩΝ, ΣΤΗ ΣΤΑΤΙΣΤΙΚΗ ΑΝΑΛΥΣΗ ΤΩΝ ΣΤΟΙΧΕΙΩΝ, ΣΤΗΝ ΔΟΜΗΣΗ ΑΡΙΘΜΗΤΙΚΩΝ ΜΟΝΤΕΛΩΝ ΚΥΚΛΟΦΟΡΙΑΣ ΚΑΙ ΣΤΗΝ ΕΠΑΛΗΘΕΥΣΗ ΤΟΥΣ ΜΕ ΤΟΝ ΚΑΛΥΤΕΡΟ ΔΥΝΑΤΟ ΤΡΟΠΟ.
On Chubanov's Method for Linear Programming
Authors: Basu Amitabh , Loera Jesús A. De , Junod Mark
Published: December 2013

We discuss the method recently proposed by S. Chubanov [Chubanov S (2012a) A strongly polynomial algorithm for linear systems having a binary solution. Math. Programming 134(3):533–570] for the linear feasibility problem. We present new, concise proofs and geometric interpretations of some of his results. From our ideas we derive the first strongly polynomial time algorithm based on relaxation method techniques for special classes of linear feasibility problems. Under certain conditions, these results provide new proofs of classical results obtained by Tardos for combinatorial linear programs. The paper ends with some experimental investigations.
Fluid Limits for Many-Server Systems with Reneging Under a Priority Policy
Authors: Atar Rami , Kaspi Haya , Shimkin Nahum
Published: December 2013

A multiclass many-server system is considered, in which customers are served according to a nonpreemptive priority policy and may renege while waiting to enter service. The service and reneging time distributions satisfy mild conditions. Building on an approach developed by Kaspi and Ramanan, the law-of-large-numbers many-server asymptotics are characterized as the unique solution to a set of differential equations in a measure space, regarded as fluid model equations. In stationarity, convergence to the explicitly solved invariant state of the fluid-model equations is established. An immediate consequence of the results in the case of exponential reneging is the asymptotic optimality of an index policy, called the cμ/θ rule, for the problem of minimizing linear queue-length and reneging costs. A certain Skorohod map plays an important role in obtaining both uniqueness of solutions to the fluid-model equations and convergence.
Determining the Optimal Configuration of Hospital Inpatient Rooms in the Presence of Isolation Patients
Authors: Pinker Edieal , Tezcan Tolga
Published: December 2013

We study the optimal configuration of hospital inpatient rooms with private and semiprivate rooms when some of the patients have infectious diseases and need to be isolated. We assume that the demand is random and seasonal. We propose a computationally efficient solution procedure that is based on a stochastic program that uses asymptotic approximations for the system performance under different admission policies and show its accuracy for large systems. Using our model, we study the appropriateness of the recent trends in hospital design calling for 100% private rooms. We show that even with isolation patients such an extreme approach could result in a significant degradation in the access of patients to hospital beds.
On the Axiomatization of the Satiation and Habit Formation Utility Models
Authors: He Ying , Dyer James S. , Butler John C.
Published: December 2013

We propose a preference condition called shifted difference independence to axiomatize a general habit formation and satiation model (GHS). This model allows for a general habit formation and satiation function that contain many functional forms in the literature as special cases. Since the GHS model can be reduced to either a general satiation model (GSa) or a general habit formation model (GHa), our theory also provides approaches to axiomatize both the GSa model and the GHa model. Furthermore, by adding extra preference conditions into our axiomatization framework, we obtain a GHS model with a linear habit formation function and a recursively defined linear satiation function.
The temporality of food practices: intergenerational relations, childhood memories and mothers’ food practices in working families with young children
Authors: Knight Abigail , O’Connell Rebecca , Brannen Julia
Published: December 2013

Drawing on the findings of a qualitative study of 48 families with young children (aged 1.5–10 years), which investigated the influence of employment on children’s diets, this article focuses on the place of childhood memories and intergenerational relations in the transmission of family food practices. The article highlights the temporal nature of family food practices. First, it examines the intergenerational transmission of food practices in relation to present time as mothers and grandmothers negotiate what and how children eat in their everyday lives. Second, it analyses the ways in which memories of childhood influence mothers’ food practices in their current families, showing how present-day family food practices are embedded in the relations between parents, grandparents and children and in the experiences of food and eating from the past. The article thereby demonstrates the importance of the interplay between food, memories of childhood experiences and intergenerational familial relations.