bluuebunny/crossref_metadata_2025 huggingface dataset:
Genetic profiling and PVY resistance identification of potato germplasm resources
Authors: Gao Yan , Tian Chenxi , Du Yizhi , Zhao Yong , Jiang Rui , Zhang Kai , Lv Dianqiu
Published: September 2024

Excellent germplasm resources are the foundation for cultivating high-quality, disease-resistant, and stress-tolerant varieties. In this study, simple sequence repeat (SSR) markers were used to identify 138 potato accessions collected from worldwide, and genetic cluster analysis was used to characterize the genetic diversity of the tested germplasm resources. The Potato virus Y (PVY) resistance of these potato accessions was identified by artificial friction inoculation combined with molecular marker detection, and potato accessions with different PVY resistance were screened based on disease index and incidence rate. Using SSR markers, 138 potato accessions were identified, and the results showed that the genetic distances between the tested potato germplasm resources ranged from 0.025 to 0.660, and the genetic similarity coefficients ranged from 0.489 to 0.975. The 138 accessions could be clustered into five subgroups using Unweighted Pair-Group Method with Arithmetic Mean (UPGMA). Among them, Z173, Biyin No. 4, Suyin No. 2, XN995, XN987, Biyin No 22, Bibiao104, Sarpo mira, XN996, XN979, Desiree, RUNSHI, Actrice, Jia 1219, Heyin No 12, and Moyin No.1 have relatively distant genetic relationship with another 122 accessions. Based on the disease index, the following different accessions were screened: five highly resistant, 11 resistant, 45 moderately resistant, 35 susceptible, and 42 highly susceptible. Fourteen resource materials with good resistance (disease index ≤ 33.74%, and a grading of high resistance (HR) or medium resistance (MR); incidence rate ≤ 67.58%) were identified. By combining genetic cluster analysis and PVY resistance identification, six accessions showed PVY resistance and had distant genetic relationships with other accessions selected which provided important materials for disease resistance breeding and quality improvement of potato. In this study, the genetic diversity and PVY resistance of global potato germplasm resources was explored, and potato germplasm materials with important utilization value were screened. The results obtained in this study could provide important references for the research and utilization of global potato germplasm resources.
Predictors of depression among caregivers of patients with severe mental illness in Northwest Ethiopia, 2023: an explanatory sequential mixed-method study
Authors: Munie Birhanu Mengist , Birhan Zelalem , Legas Getasew , Asnakew Sintayehu , Belete Amsalu , Beyene Getnet Mihretie , Shiferaw Kirubel , Mulu Anemut Tilahun , Kassie Yohannes Tesfahun , Aytenew Tigabu Munye , Tedla Assasahegn
Published: September 2024

Background

Severe mental illness results in an enormous social and economic burden on affected individuals, their families, and communities, especially in developing countries, such as Ethiopia.

Objective

The aim of this study was to assess the level of depression among caregivers of patients with severe mental illness in Debre Tabor Town, Northwest Ethiopia in 2023.

Methods

This institution-based explanatory mixed study was conducted at Debre Tabor Compressive Specialized Hospitals between September 30 to October 30, 2023. A systematic random sampling technique was used to select 260 study participants, and a public health questionnaire was used to assess depression. Epicollect5 was used to collect data, which were then exported to the SPSS-25 for analysis. Variables with a p-value <0.25 were considered candidates for the multivariate logistic regression analysis. The odds ratios with a 95% confidence interval were used to determine the strength of the association. An in-depth interview was conducted with 11 participants, selected using purposive sampling.

Results

The prevalence of depression was 31.3% (95% CI = 29.7–38.6). The multivariate analysis showed that being female (AOD = 2.43, CI = 1.42–7.23), divorced/widowed (AOD = 1.8, CI = 1.32–6.34), poor social support (AOD = 2.2, CI = 1.9–5.87), and perceived stigma (AOD = 2.33, CI = 0.24–13.22) were positively associated with depression. The qualitative results suggest that being female, illiterate, severity of the illness, poor social support, and stigma were factors for depression.

Conclusions and recommendations

The prevalence of depression was high among caregivers of patients with severe mental illness. Female sex, being divorced or widowed, being illiterate, poor social support, and perceived stigma were the contributing factors. This implies that a greater focus on caregivers and the government increases mental health literacy and mental health community services.
Exploring psychosocial factors influencing sexually transmitted infection intention testing among medical students: a cross-sectional study in two universities
Authors: Loaiza-Guevara Valentina , Acosta María Alejandra Gómez , Álvarez Angie Valeria Aguirre , Martínez Valentina Agudelo , Montoya María Camila Montes , Ramírez Alexandra Agudelo , Izquierdo-Condoy Juan S.
Published: September 2024

Background

Despite the significant global burden of sexually transmitted infections (STI), detection rates are poor. Acceptance of these tests is influenced by several factors that have not been explored among Colombian medical students.

Objectives

The aim of this study was to describe the behaviors and psychosocial factors toward STI screening among medical students of two universities in Pereira, Colombia, between March and June 2020.

Methods

An observational, cross-sectional study was conducted with 284 medical students in the first 3 years of undergraduate at two universities. An online, self-administered survey was conducted between March 2020 and June 2020, using an instrument from the “STI Testing Questionnaire,” to assess behaviors and psychosocial factors toward STI testing. Frequencies and percentages were used for descriptive analysis. The association between characteristics and psychosocial factors with STI testing intention was obtained using a logistic regression model. A p-value <0.05 was accepted as statistically significant for all analyses.

Results

A total of 284 medical students participated in this study. The majority were female (56.7%), and 53.2% were from private universities. Eighty-four point 5% (84.5%) had risky sexual behaviors, and only 32.4% reported intentions to be tested for STIs. Among the psychosocial factors, 64.1% reported high social pressure, and 43.0% reported social fear. An association with the intention to undergo STI testing was identified in those who had been previously tested (OR = 2.486; 95% CI: 1.492–4.142) and in those who engaged in risky sexual behaviors (OR = 3.537; 95% CI: 1.437–8.704).

Conclusion

Medical students exhibit a high prevalence of risky sexual behaviors but show a disturbing lack of intention to undergo STI screening. Prior experiences significantly influence screening intentions, while social pressure and fear also play a role. These insights can serve as a basis for targeted interventions to improve STI screening rates and enhance sexual health education among Colombian medical students.
Understanding adolescent consumption patterns and attitudes towards the “puff” on the path to a smoke-free generation: a 2022 French perspective
Authors: Cottin Marin , Catellin Marion , De Guiran Elen , Miliani Katiuska , Josseran Loïc , Gautier Sylvain
Published: September 2024

Purpose

Tobacco use remains the leading preventable cause of death in France, with 75,000 deaths each year. France aims to reduce smoking and achieve a smoke-free generation by 2032. However, recent tobacco industry innovations which mainly target young people, could undermine this goal. The main objective of this study is to assess the knowledge and consumption patterns of the “puff” among French adolescents in 2022.

Methods

A cross-sectional study using a structured online survey on a representative sample of 400 adolescents aged 13 to 16 years was conducted from July 4th to 20th, 2022.

Results

Around 66% of adolescents reported having heard of the puff”, and one in ten having tried it. Slightly fewer of them have tried cigarettes; 89.6% of experimenters reported that it allowed them to explore unique flavors, 81.9% found it fun to play with the puff-cloud, and 94.5% of regular consumers considered it a stylish or cool product. 76% of adolescents believe that the puff is dangerous to their health, 71.6% describe it as a polluting device, and 62.8% think it’s a gadget.

Conclusion

The “puff” is widely known by French adolescents and more commonly used than cigarettes, due, in part, to marketing specifically designed to target youth. That is why it could represent a threat to the smoke-free generation objectives. Public health policy could be informed by the ecological awareness of adolescents as a new lever of counter-influence to prevent this kind of consumption, as did ACT with the #stopcigarettespollution prevention campaign.
Disproportionate preponderance of HPV genotypes associated with anogenital warts among HIV-positive MSM
Authors: Borena Wegene , Kitchen Maria , Gisinger Martin , Taylor Ninon , Oberkofler Hannes , Dewasurendra Diyani , Widschwendter Andreas , Stoiber Heribert , von Laer Dorothee , Sarcletti Mario
Published: September 2024

Background

In this study, we characterized the HPV genotype distribution in a population of 489 adults already positive for HPV DNA. The study population was divided into two groups: 244 HIV-positive (HIV+) men who have sex with men (MSM) undergoing routine anal screening for sexually transmitted diseases (STDs) and 245 women undergoing routine cervical cancer screening. Acknowledging the fact that women and MSM represent two independent circles of sexual practices, which are—largely—exclusive of each other, we were interested in determining if particular genotypes of human papillomavirus (HPV) disproportionately predominate in one of these circles compared to the other.

Results

HIV+ MSM are significantly more likely to be infected with multiple genotypes at a time, with an odds ratio (OR) of 9.30 (95% confidence interval [CI]: 3.91–22.1) and a p-value of <0.001. In addition, multivariable-adjusted logistic regression analysis showed that anal swab samples were significantly more likely to harbor lrHPV infections, with an OR of 6.67 (95% CI: 2.42–18.4) and a p-value of <0.001, in particular, HPV 6, with an OR of 8.92 (95% CI: 3.84–20.7) compared to cervical samples of screening women.

Conclusion

Given the significant impact of recurrent anogenital warts (AGWs) on quality of life and the accompanying predisposition to invasive anal cancer, our data underscore the critical need for HPV vaccination. This includes expanding vaccination eligibility to include both boys and adults within high-risk populations.
Light and scanning electron microscopy of the eye of Siganus luridus (Rüppell, 1828)
Authors: Derbalah Amira , El-Gendy Samir A. A. , Abd-Elhafeez Hanan H. , Soliman Soha , El-Mansi Ahmed A. , Seif Manal , Rashwan Ahmed M. , Eldesoqui Mamdouh B. , Rutland Catrin Sian , Kubale Valentina , Alsafy Mohamed A. M.
Published: September 2024

Introduction

The morphological characteristics of eyes in fishes are highly diverse and have evolved to meet the specific visual requirements as per their habitats. These morphological features of eyes are important for researchers and ecologists. The dusky spinefoot (Siganus luridus) is a tropical teleost fish with a laterally flattened body which lives in the Mediterranean Sea. Currently, there are no histological data relating to the Siganus luridus eye.

Methods

In this study, the morphology of the Siganus luridus eye was examined to enhance our understanding of its structure and its relationship to fish ecology. Detailed gross and microscopic features were recorded using light and scanning microscopy.

Results

The key observations describe the main structural features of the eye of Siganus luridus, specifically, the diameter of the orbit, architecture of three tunics of eye and detailed lens description. The choroid was divided into four layers, and had a rete mirabile, consisting of numerous small blood vessels in the choroidal gland. The tapetum lucidum was observed, which is interesting since Siganus luridus is herbivore and herbivores typically lack a tapetum lucidum.

Discussion

These observations shed new light on the intricate eye structure of Siganus luridus and provide valuable insights into its visual abilities and adaptations to the aquatic environment and feeding behavior.
The hypothalamic transcriptome reveals the importance of visual perception on the egg production of Wanxi white geese
Authors: Yang Lei , Jia Changze , Li Yanzhong , Zhang Yafei , Ge Kai , She Deyong
Published: September 2024

Egg performance significantly impacts the development of the local goose industry. The hypothalamus plays an essential role in the egg production of birds. However, few potential candidate genes and biological functions related to egg production in geese have been identified in hypothalamus tissue. In this study, 115 geese were raised and observed for 5 months during the laying period. To understand the regulation mechanism of egg production, the hypothalamus transcriptome profiles of these geese were sequenced using RNA-seq. The hypothalamus samples of four high egg production (HEP) and four low egg production (LEP) geese were selected and collected, respectively. A total of 14,679 genes were identified in the samples. After multiple bioinformatics analyses, Gene Ontology (GO) annotations indicated that genes related to egg production were mainly enriched in biological processes of “response to light stimulus,” “sensory system development,” and “visual perception.” Six potential candidate genes (PDE6C, RHO, MFRP, F2, APOB, and IL6) based on their corresponding GO terms and interaction networks were identified. These identified candidate genes can be used as selection markers to improve the egg production of Wanxi white geese. Our study highlights how visual perception may affect the regulation of geese egg production.
Canine idiopathic generalized tremor syndrome, immune-mediated?
Authors: Kajin Filip , Meyerhoff Nina , Meller Sebastian , Carlson Regina , Tipold Andrea , Gutierrez-Quintana Rodrigo , Kaczmarska Adriana , Sanchez-Masian Daniel , Ives Edward , Brocal Josep , von Klopmann Thilo , Hauer Julia , Volk Holger Andreas
Published: September 2024

Idiopathic generalized tremor syndrome is a disorder characterized by an acute onset of full-body tremors, sometimes accompanied by vestibulo-cerebellar signs, that is responsive to treatment with corticosteroids. Although considered to have an overall good outcome, relapsing and persistent mild clinical signs have been described. So far, little is known about the etiopathology of this syndrome, but it is believed to have an immune-mediated origin. In human medicine, description of numerous autoantibodies involved in certain non-infectious neurologic disorders has revolutionized understanding of their pathophysiology, diagnosis and treatment. In this multicenter retrospective study, we aimed to describe the clinical signs, course, and outcome of dogs with idiopathic generalized tremor syndrome and correlate potential findings with the presence or absence of autoantibodies associated with autoimmune cerebellar syndromes in humans. Information regarding signalment, history, clinical signs, laboratory findings, diagnostic imaging and testing for regional infectious diseases was gathered and the remaining serum and CSF samples were then analyzed for neural antibodies against targets associated with autoimmune encephalitic diseases of humans. Thirty-three dogs were included, and screening for neural antibodies was performed in 30 of those dogs. The analysis showed an increased titer of mGluR1 antibodies in two dogs, GFAP and later in the course of disease mGluR1 antibodies in one dog and an increase in unspecific autoantibodies which could not be further classified in two dogs. Dogs with detectable neural autoantibodies always had cerebrospinal fluid abnormalities in the form of a pleocytosis, with or without increased protein concentration, and tended to present with hyperthermia, potentially indicating a more severe clinical form of idiopathic generalized tremor syndrome in these cases. In conclusion, idiopathic generalized tremor syndrome is proposed to be an immune-mediated disorder potentially mediated by neural autoantibodies in a subgroup of dogs.
Drag Reduction on the Basis of the Area Rule of the Small-Scale Supersonic Flight Experiment Vehicle Being Developed at Muroran Institute of Technology (Second Report)
Authors: Mizobata Kazuhide , Mio Taichi , Miyamoto Katsuya
Published: September 2024

A small-scale supersonic flight experiment vehicle named OWASHI is being developed at Muroran Institute of Technology as a flying testbed for verification of innovative technologies for high-speed atmospheric flights. Drag reduction in the transonic and supersonic regimes is quite crucial for attainability of its supersonic flights. This study aims to obtain configuration modification for transonic drag reduction on the basis of the so-called area rule. In order to prevent accumulation of compression waves, various profiles of the bottleneck and the bulge are designed by using arcs with constant and large radii and spline curves approximating them. Their effects are assessed through CFD analysis, wind tunnel tests, and wave drag analysis. As a result, an area-rule-based configuration with a sharpened conical nose and a large-radius bottleneck achieves significant drag reduction in a transonic Mach range, as well as 57-count (57 × 10−4) reduction at the design Mach number of 1.1. However, the drag reduction effects of bulges are small and apparent only in a narrow Mach range. On the other hand, in the practical vehicle configuration, rearward fuselage extension shows a large amount of drag reduction, whereas the addition of an intake cancels the drag reduction effects of area-rule-based configurations.
Probabilistic Ensemble Framework for Injury Narrative Classification
Authors: Vichare Srushti , Nanda Gaurav , Sundararajan Raji
Published: September 2024

In this research, we analyzed narratives from the National Electronic Injury Surveillance System (NEISS) dataset to predict the top two injury codes using a comparative study of ensemble machine learning (ML) models. Four ensemble models were evaluated: Random Forest (RF) combined with Logistic Regression (LR), K-Nearest Neighbor (KNN) paired with RF, LR combined with KNN, and a model integrating LR, RF, and KNN, all utilizing a probabilistic likelihood-based approach to improve decision-making across different classifiers. The combined KNN + LR ensemble achieved an accuracy of 90.47% for the top one prediction, while the KNN + RF + LR model excelled in predicting the top two injury codes with a very high accuracy of 99.50%. These results demonstrate the significant potential of ensemble models to enhance unstructured narrative classification accuracy, particularly in addressing underrepresented cases, and the potential of the proposed probabilistic ensemble framework ML models in improving decision-making in public health and safety, providing a foundation for future research in automated clinical narrative classification and predictive modeling, especially in scenarios with imbalanced data.
Glioma Stem Cells: GPRC5A as a Novel Predictive Biomarker and Therapeutic Target Associated with Mesenchymal and Stemness Features
Authors: Aghamiri Sara Sadat , Amin Rada
Published: September 2024

Glioblastoma multiforme (GBM) represents the deadliest form of brain cancer, characterized by complex interactions within its microenvironment. Despite the understanding of GBM biology, GBM remains highly resistant to any therapy. Therefore, defining innovative biomarkers in GBM can provide insights into tumor biology and potential therapeutic targets. In this study, we explored the potential of GPRC5A to serve as a pertinent biomarker for GBM. We utilized the GBM-TCGA dataset and presented the reproducible bioinformatics analysis for our results. We identified that GPRC5A expression was significantly upregulated in GBM compared to normal tissues, with higher levels correlating with poor overall survival (OS) and progression-free interval (PFI). Moreover, it was associated with key genetic mutations, particularly NF1 and PTEN mutations, and strongly correlated with the mesenchymal stem-like phenotype. GPRC5A was also predominantly associated with aggressive GBM features, including hypoxia, high extracellular matrix (ECM) environments, and extensive stromal and immune infiltrations. Its strong correlation with mesenchymal markers and hypoxic regions underscores its potential as a biomarker and therapeutic target in GBM. These findings provide valuable insights into the role of GPRC5A in GBM pathology and its potential impact as a target for GBM stratifications and treatment strategies.
Housing Design for Health in a Changing Climate for Remote Indigenous Communities in Semi-Arid Australia
Authors: Memmott Paul , Lansbury Nina , Nash Daphne , Snow Stephen , Redmond Andrew M. , Burgen (Waanyi) Clarissa , Matthew Paul , Quilty Simon , Frank (Warumungu) Patricia Narrurlu
Published: September 2024

Architecture can be very influential in enabling health and wellbeing in the residential built environment. In arid regions, health-supportive design would consider major environmental hazards, such as heat and dust, as well as social and cultural factors that influence household size and composition. Under current and projected conditions, the effects of climate change will increase, presenting opportunities and challenges to architects to demonstrate and deliver best practice in climate-appropriate and culturally appropriate housing design. This paper brings together a multidisciplinary team of researchers to identify the current and future needs for tropical semi-arid zone design with a focus on Indigenous communities in northern Central Australia. In a narrative review of the literature and exploratory fieldwork, current and projected impacts of climate change on housing, health, energy systems and behavioural practices are explored in a holistic way. Our findings demonstrate the growing awareness of climate-related issues for remote Indigenous housing but also the lack of place-based studies that might inform adaptation strategies. Overwhelmingly, there is limited understanding of local lived experiences that may be highly significant for developing resilience in a changing climate. Consideration of the beliefs, values and practices of Indigenous people will be integral to design solutions.
Neurotransmitter Availability and Anti-Inflammatory and Antioxidant Effects of Subacute Administration of Aloysia gratissima (Gillies & Hook) Tronc. and Rutin in Female Wistar Rats
Authors: Schreiner Gênifer Erminda , Schmitt Elizandra Gomes , Brittes Gabriela Escalante , dos Santos Laura Smolski , Maders Luana Tamires , Gonçalves Itamar Luís , de Moura Sarmento Sílvia Muller , Dartora Nessana , Manfredini Vanusa
Published: September 2024

Background: Levels of chronic inflammation, oxidative stress, and neurotransmitter availability are altered in depressed patients and can be used as biological markers. This study aimed to analyze these markers in female Wistar rats under chronic inflammation induced by E. coli lipopolysaccharide (LPS), treated with aqueous extract of A. gratissima and rutin, the major flavonoid of its extract. Methods: Thirty female Wistar rats under a chronic inflammatory regimen induced by 1 mg/kg i.p. of LPS were divided into six experimental groups: control (1), treated with fluoxetine 5 mg/kg (2), rutin at 50 mg/kg (3) or 100 mg/kg (4), aqueous extract of A. gratissima 100 mg/kg (5), and co-treatment with 50 mg/kg of extract and 10 mg/kg of rutin (6). Treatments were administered by gavage for 15 days. Results: Oxidative damage to proteins and lipids was lower in group 6 compared to group 2. Pro- and anti-inflammatory cytokines increased in group 1 but not in group 2, indicating a relationship with depression. Similar effects were observed in the treated groups, showing no significant differences from group 2. Neurotransmitter levels of dopamine and serotonin were low in group 1, and all treatments effectively increased them. Additionally, A. gratissima extract at 100 ppm increased locomotor activity in planarians. Conclusions: This study demonstrates the effectiveness of the LPS induction model in subacute experimental designs and the potential antidepressant effect of the treatments due to their antioxidant and anti-inflammatory properties, and ability to increase neurotransmitter levels.
Simplified Cost Functions Meet Advanced Muscle Models to Streamline Muscle Force Estimation
Authors: Ahmed Muhammad Hassaan , N’Guessan Jacques-Ezechiel , Das Ranjan , Leineweber Matthew , Goyal Sachin
Published: September 2024

Background/Objectives: This study explores an optimization-based strategy for muscle force estimation by employing simplified cost functions integrated with physiologically relevant muscle models. Methods: Considering elbow flexion as a case study, we employ an inverse-dynamics approach to estimate muscle forces for the biceps brachii, brachialis, and brachioradialis, utilizing different combinations of cost functions and muscle constitutive models. Muscle force generation is modeled by accounting for active and passive contractile behavior to varying degrees using Hill-type models. In total, three separate cost functions (minimization of total muscle force, mechanical work, and muscle stress) are evaluated with each muscle force model to represent potential neuromuscular control strategies without relying on electromyography (EMG) data, thereby characterizing the interplay between muscle models and cost functions. Results: Among the evaluated models, the Hill-type muscle model that incorporates both active and passive properties, combined with the stress minimization cost function, provided the most accurate predictions of muscle activation and force production for all three arm flexor muscles. Our results, validated against existing biomechanical data, demonstrate that even simplified cost functions, when paired with detailed muscle models, can achieve high accuracy in predicting muscle forces. Conclusions: This approach offers a versatile, EMG-free alternative for estimating muscle recruitment and force production, providing a more accessible and adaptable tool for muscle force analysis. It has profound implications for enhancing rehabilitation protocols and athletic training, not only broadening the applicability of muscle force estimation in clinical and sports settings but also paving the way for future innovations in biomechanical research.
Dealkylation of Macromolecules by Eukaryotic α-Ketoglutarate-Dependent Dioxygenases from the AlkB-like Family
Authors: Davletgildeeva Anastasiia T. , Kuznetsov Nikita A.
Published: September 2024

Alkylating modifications induced by either exogenous chemical agents or endogenous metabolites are some of the main types of damage to DNA, RNA, and proteins in the cell. Although research in recent decades has been almost entirely devoted to the repair of alkyl and in particular methyl DNA damage, more and more data lately suggest that the methylation of RNA bases plays an equally important role in normal functioning and in the development of diseases. Among the most prominent participants in the repair of methylation-induced DNA and RNA damage are human homologs of Escherichia coli AlkB, nonheme Fe(II)/α-ketoglutarate-dependent dioxygenases ABH1–8, and FTO. Moreover, some of these enzymes have been found to act on several protein targets. In this review, we present up-to-date data on specific features of protein structure, substrate specificity, known roles in the organism, and consequences of disfunction of each of the nine human homologs of AlkB. Special attention is given to reports about the effects of natural single-nucleotide polymorphisms on the activity of these enzymes and to potential consequences for carriers of such natural variants.
Effects of Curcumin on Radiation/Chemotherapy-Induced Oral Mucositis: Combined Meta-Analysis, Network Pharmacology, Molecular Docking, and Molecular Dynamics Simulation
Authors: Chen Zhi-Xing , Qin Ya-Shi , Shi Bang-Hui , Gao Bi-Yun , Tao Ren-Chuan , Yong Xiang-Zhi
Published: September 2024

The study aims to investigate the effects of curcumin on radiation/chemotherapy-induced oral mucositis (R/CIOM) and preliminarily explore its mechanism. Randomized controlled trials were identified from the PubMed, Embase, Web of Science, Cochrane Library, Medline, and Google Scholar databases. RevMan 5.4 was used for statistical analysis to calculate the combined risk ratios (RRs). The mechanism was analyzed through network pharmacology, molecular docking, and a molecular dynamics simulation. The targets of curcumin were collected in HERB, PharmMapper, Targetnet, Swiss Target Prediction, and SuperPred. OMIM, GeneCards, and Disgenet were used to collect relevant targets for R/CIOM. Cytoscape software 3.8.0 was used to construct the component-target-pathway network. Protein–Protein Interaction (PPI) networks were constructed using the STRING database. GO and KEGG enrichment analyses were performed by Metascape. AutoDock Vina 4.2 software was used for molecular docking. The molecular dynamics simulation was performed by Gromacs v2022.03. It is found that 12 studies involving 565 patients were included. Meta-analyses showed that curcumin reduced the incidence of severe R/CIOM (RR 0.42 [0.24, 0.75]) and the mean severity of R/CIOM (MD -0.93 [−1.34, −0.52]). Eleven core target genes were identified in the treatment of R/CIOM with curcumin. The results of molecular docking and the molecular dynamics simulation showed that curcumin had strong binding energy and stability with target proteins including MAPK3, SRC, and TNF. Overall, these findings suggest curcumin can effectively improve severe R/CIOM, perhaps by affecting MAPK3, SRC, and TNF.
Data on Economic Analysis: 2017 Social Accounting Matrices (SAMs) for South Africa
Authors: Pfunzo Ramigo , Bahta Yonas T. , Jordaan Henry
Published: September 2024

The purpose of the Social Accounting Matrix (SAM) is to improve the quality of the database for modelling, including, but not limited to, policy analysis, multiplier analysis, price analysis, and Computable General Equilibrium. This article contributes to constructing the 2017 national SAM for South Africa, incorporating regional accounts. Only in Limpopo Province of South Africa are agricultural industries, labour, and households captured at the district level, while agricultural industry, labour, and household accounts in other provinces remain unchanged. The main data sources for constructing a SAM are found from different sources, such as Supply and Use Tables, National Accounts, Census of Commercial Agriculture, Quarterly Labour Force Survey, South Africa Revenue Service, Global Insight (regional explorer), and South Africa Reserve Bank. The dataset recorded that land returns for irrigation agriculture were highest (18.2%) in the Northern Cape Province of South Africa compared to other provinces, whereas the Free State Province of South Africa rainfed agriculture had the largest shares (22%) for payment to land. Regarding intermediate inputs, rainfed agriculture in the Western Cape, Free State, and Kwazulu-Natal Provinces paid approximately 0.4% for using intermediate inputs. In terms of the districts, land returns for irrigation were highest in the Vhembe district of Limpopo Province of South Africa with 0.3%. Despite Mopani district of Limpopo Province of South Africa having the lowest land returns for irrigation agriculture, it has the highest share (1.6%) of payment to land from rainfed agriculture. The manufacturing and community service sectors had a trade deficit, whereas other sectors experienced a trade surplus. The main challenges found in developing a SAM are scarcity of data to attain the information needed for disaggregation for the sub-matrices and insufficient information from different data sources for estimating missing information to ensure the row and column totals of the SAM are consistent and complete.
Development of the ‘Healthy Eating Index for Older People’ to Measure Adherence to Dietary Guidelines in Healthy Older New Zealand Adults
Authors: Mumme Karen D , de Seymour Jamie V , Conlon Cathryn A , von Hurst Pamela R , Guy Harriet , Gammon Cheryl S , Beck Kathryn L
Published: September 2024

This study aimed to develop the ‘Healthy Eating Index for Older People’ (the index), based on New Zealand dietary guidelines, and measures the validity and reproducibility of a food frequency questionnaire (FFQ) to derive the index scores in older adults. In Auckland, New Zealand, participants (community-dwelling adults aged 65–74 years, [n = 273, 36% male]) completed a 109-item FFQ administered one month apart (FFQ1, FFQ2), with a four-day food record (4-DFR) collected in between. Adherence to the guidelines was scored using the index, comprising a total score (maximum = 100) and two sub-scores: adequacy (maximum = 60) and moderation (maximum = 40). A comparison of FFQ1 and FFQ2 determined reproducibility, and FFQ1 and 4-DFR determined validity. Higher index scores (from FFQ1) were associated with higher intakes of protein, fibre, vitamins and minerals and lower intakes of alcohol and saturated fats (nutrients from 4-DFR) after adjusting for age and sex (all p < 0.001). Total index and sub-indices correlation coefficients ranged from 0.42 to 0.77 (all p < 0.001); weighted kappa values ranged from 0.35 to 0.67; and mean differences were all <10% of FFQ1 for reproducibility and validity. The Bland–Altman analysis showed no bias for the total index score for reproducibility and validity. However, with validation, the sub-index scores became less reliable as food intake increased (p < 0.05). The index applied to the FFQ demonstrated good construct validity and reproducibility. Relative and absolute validity were acceptable, though caution is required when using the absolute sub-index scores. The index is suitable for measuring total diet quality in older New Zealand adults.
Conductive Coatings on PDMS, PMMA, and Glass: Comparative Study of Graphene, Graphene Oxide, and Silver Nanoparticle Composites
Authors: Sun Jing , Guo Qiang , Dai Wanqing , Chen Jian Lin , Mao Guozhu , Peng Yung-Kang
Published: September 2024

The development of conductive coatings has significant implications for microelectronics and electrochemistry. However, conductive coatings may exhibit different electrochemical properties when prepared on different substrate materials. This research explores the comparative performance of graphene, graphene oxide (GO), and silver nanoparticle (Ag NP) composites as conductive coatings on diverse substrate materials, including polydimethylsiloxane (PDMS), polymethyl methacrylate (PMMA), and glass. The study employed various preparation methods, such as mixing conductive materials with substrate materials and preparing copolymer composite materials. The conductive coating approach was found to be the most straightforward and convenient, with broader development prospects and fewer restrictive conditions. The results indicate that the distinct surface characteristics of the substrate materials influence the conductive properties of coating materials. Consequently, results show that graphene exhibits the highest conductivity on all three substrates, while GO is more conductive than Ag NPs on PMMA and PDMS but less conductive than Ag NPs on glass. That offers valuable insights into the selection of substrate materials and coating materials for the preparation of conductive materials.
Energy Efficiency in Buildings: Toward Climate Neutrality
Authors: Babiarz Bożena , Krawczyk Dorota Anna , Siuta-Olcha Alicja , Manuel Candida Duarte , Jaworski Artur , Barnat Ewelina , Cholewa Tomasz , Sadowska Beata , Bocian Martyna , Gnieciak Maciej , Werner-Juszczuk Anna , Kłopotowski Maciej , Gawryluk Dorota , Stachniewicz Robert , Święcicki Adam , Rynkowski Piotr
Published: September 2024

The pursuit of climate neutrality requires global systemic actions involving the use of solutions aimed at reducing emissions. Changes must be introduced in all sectors affecting climate change, namely power engineering and district heating, construction, transport, and industry, as well as agriculture and forestry. Analyzing the structure of final energy consumption in the EU by sector, it can be stated that households account for 27% of the total energy consumption. Comprehensive actions are needed to increase the energy efficiency of buildings. The aim of this paper was to indicate aspects of improving energy efficiency in buildings and their equipment, taking into account the striving for climate neutrality. Analyzed possibilities and conditions of using various solutions of energy-efficient systems aimed at increasing energy resilience and security and preventing environmental degradation. Particular attention was paid to construction and material solutions, as well as installation solutions, which increased the accumulation and energy efficiency of the building. These activities are closely related to the conditions and dynamics of the heat exchange process in the applied solutions and are also related to the factors influencing thermal comfort and energy consumption in buildings. Due to the growing popularity of modern information technologies and artificial intelligence in energy management in recent years, this article reviews the latest research in this area. One of the directions of future research indicated by scientists is autonomous building control in real time, adapting to the momentary needs of users. The analysis of the possibilities of using modern energy efficiency solutions in buildings conducted in this work may be useful for optimizing heat and energy management models and models of society’s consumption as an element of energy transformation towards climate neutrality and counteracting the deepening of energy poverty.
Smart Materials and Devices for Energy Saving and Harvesting
Authors: Cannavale Alessandro , Ayr Ubaldo
Published: September 2024

The decarbonisation objectives set for 2050 compel us to envisage any effective strategy in order to reduce the human impact on the planet, drastically reducing greenhouse gas emissions to reduce the effects of global warming [...]
A Comprehensive Review of Generative AI in Finance
Authors: Lee David Kuo Chuen , Guan Chong , Yu Yinghui , Ding Qinxu
Published: September 2024

The integration of generative AI (GAI) into the financial sector has brought about significant advancements, offering new solutions for various financial tasks. This review paper provides a comprehensive examination of recent trends and developments at the intersection of GAI and finance. By utilizing an advanced topic modeling method, BERTopic, we systematically categorize and analyze existing research to uncover predominant themes and emerging areas of interest. Our findings reveal the transformative impact of finance-specific large language models (LLMs), the innovative use of generative adversarial networks (GANs) in synthetic financial data generation, and the pressing necessity of a new regulatory framework to govern the use of GAI in the finance sector. This paper aims to provide researchers and practitioners with a structured overview of the current landscape of GAI in finance, offering insights into both the opportunities and challenges presented by these advanced technologies.
Robust Design of Two-Level Non-Integer SMC Based on Deep Soft Actor-Critic for Synchronization of Chaotic Fractional Order Memristive Neural Networks
Authors: Roohi Majid , Mirzajani Saeed , Haghighi Ahmad Reza , Basse-O’Connor Andreas
Published: September 2024

In this study, a model-free  PIφ-sliding mode control ( PIφ-SMC) methodology is proposed to synchronize a specific class of chaotic fractional-order memristive neural network systems (FOMNNSs) with delays and input saturation. The fractional-order Lyapunov stability theory is used to design a two-level  PIφ-SMC which can effectively manage the inherent chaotic behavior of delayed FOMNNSs and achieve finite-time synchronization. At the outset, an initial sliding surface is introduced. Subsequently, a robust  PIφ-sliding surface is designed as a second sliding surface, based on proportional–integral (PI) rules. The finite-time asymptotic stability of both surfaces is demonstrated. The final step involves the design of a dynamic-free control law that is robust against system uncertainties, input saturations, and delays. The independence of control rules from the functions of the system is accomplished through the application of the norm-boundedness property inherent in chaotic system states. The soft actor-critic (SAC) algorithm based deep Q-Learning is utilized to optimally adjust the coefficients embedded in the two-level  PIφ-SMC controller’s structure. By maximizing a reward signal, the optimal policy is found by the deep neural network of the SAC agent. This approach ensures that the sliding motion meets the reachability condition within a finite time. The validity of the proposed protocol is subsequently demonstrated through extensive simulation results and two numerical examples.
Constitutional Factors and Irradiation as Risk Factors for Thymoma: A European Case–Control Study
Authors: Kaerlev Linda , Eriksson Mikael , Guénel Pascal , Merletti Franco , Morales-Suárez-Varela Maria , Ahrens Wolfgang , Jöckel Karl-Heinz , Llopis-Gonzalez Agustin , Wingren Gun , Simonato Lorenzo
Published: September 2024

Little is known about the aetiology of thymoma. This study aims to identify medical risk factors for thymoma as a systematic approach to new hypotheses on the aetiology of this disease. A European multi-centre case–control study was conducted from 1995 to 1997, including incident cases aged 35–69 years with thymoma. Altogether, we accepted 85 cases and 3350 controls, of which we interviewed 77 cases and 2071 population controls about constitutional factors, medical examinations, and former diseases. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated. Medical examinations with X-ray or radiotherapy performed >20 times at least one year before the thymoma diagnosis indicated a possible risk factor for thymoma (OR 1.58, 95% CI 0.93–2.69). Having the first radiotherapy treatment at least one year before the thymoma diagnosis yielded an OR for thymoma of 2.39; 95% CI (0.96–5.99), and if it was at least five years before, the OR for thymoma was 2.81; 95% CI (1.03–7.72). Having a red/auburn hair colour was associated with thymoma, (OR 3.6, 95% CI 1.4–9.5) whereas having pigmented skin was slightly associated with thymoma (OR 1.8, 95% CI 0.8–3.8). Over twenty instances of X-ray examinations or radiotherapy were identified as potential risk factors for thymoma, along with certain constitutional factors. The observed correlations between benign tumours and thymoma could stem from an inherent predisposition to tumour development or result from detection bias. Given that this is the initial analytical study examining medical risk factors for thymoma, all of the results should be approached with caution, acknowledging the possibility that some findings might be incidental.
Evaluating Access to Health Care in Mothers and Caregivers of Children under Five Years of Age in Rural Communities of Yucatán, Mexico
Authors: Rodríguez Elsa , Andueza Guadalupe , Ojeda Ricardo , Palmisano Erin , Ewald Louisa , Kamath Aruna M. , Flaxman Abraham , Sanapoori Shwetha H. , Hernandez Bernardo
Published: September 2024

Populations in rural communities have more limited access to health care and attention than urban populations. The present study aimed to evaluate barriers to access to health care in mothers and caregivers of children under five years of age, twelve months after an educational intervention. The study was carried out from February to September 2022, and 472 mothers from eight communities in the state of Yucatán, in the southeast of the United Mexican States, participated. A comparative analysis was carried out on help-seeking times, obstacles to reaching it, and illnesses in children. The results revealed that the main barriers to access to care were long times to decide to seek help, lack of financial resources to pay for the transfer to another health unit, lack of someone to accompany the mother or caregiver when the child needed be transferred, and lack of transportation for the transfer. Disease knowledge remained at different levels in the eight communities; the significant differences occurred in four communities, one specifically for heart defects. It was concluded that, in the rural populations studied, there are barriers to access to health care which have to do with neglected social determinants, such as those related to conditions of gender, income, social support network, and the health system. Access to health care must be universal, so public health interventions should be aimed at reducing the barriers that prevent the population from demanding and using services in a timely manner.
Autophagy as a Guardian of Vascular Niche Homeostasis
Authors: Dergilev Konstantin , Gureenkov Alexandre , Parfyonova Yelena
Published: September 2024

The increasing burden of vascular dysfunction on healthcare systems worldwide results in higher morbidity and mortality rates across pathologies, including cardiovascular diseases. Vasculopathy is suggested to be caused by the dysregulation of vascular niches, a microenvironment of vascular structures comprising anatomical structures, extracellular matrix components, and various cell populations. These elements work together to ensure accurate control of the vascular network. In recent years, autophagy has been recognized as a crucial regulator of the vascular microenvironment responsible for maintaining basic cell functions such as proliferation, differentiation, replicative senescence, and apoptosis. Experimental studies indicate that autophagy activation can be enhanced or inhibited in various pathologies associated with vascular dysfunction, suggesting that autophagy plays both beneficial and detrimental roles. Here, we review and assess the principles of autophagy organization and regulation in non-tumor vascular niches. Our analysis focuses on significant figures in the vascular microenvironment, highlighting the role of autophagy and summarizing evidence that supports the systemic or multiorgan nature of the autophagy effects. Finally, we discuss the critical organizational and functional aspects of the vasculogenic niche, specifically in relation to autophagy. The resulting dysregulation of the vascular microenvironment contributes to the development of vascular dysfunction.