bluuebunny/crossref_metadata_2025 huggingface dataset:
CORRECCIÓN DEL FACTOR DE POTENCIA COMO ESTRATEGIA
DE EFICIENCIA ENERGÉTICA EN EL HOTEL SIERRA
HUASTECA INN
Authors: Izaguirre B.I. Lara , Montalvo E. Torres , Guzmán M. Alvarado
Published: January 2022

El presente trabajo aborda la corrección del Factor de Potencia (FP), utilizando datos de facturación del consumo eléctrico de 2019 en un Hotel de 4 estrellas ubicado en la Huasteca Potosina. Estimando el tamaño de banco de capacitores que pueden corregir y elevar el FP por lo menos a 90% y con ello reducir las pérdidas de energía eléctrica, evitar los cargos por penalización de bajo FP, así como contribuir a la disminución de emisiones de Gases de CO2. El Hotel erogó la cantidad de $109 778.00 en su facturación eléctrica por concepto de bajo FP. Se determinó que el tamaño del banco de capacitores para esta corrección es de 30kVAR, con una inversión de $40 000.00, misma que se recuperaría en aproximadamente 5 meses.
HERRAMIENTAS DIGITALES DE EVALUACIÓN EN LÍNEA PARA
MEJORAR LA APROBACIÓN EN APRENDIZAJES DINÁMICOS
Authors: Cano O. A. García , Reyes A. A. Gutiérrez , Salazar E. A. Meraz , Torres J.C. Reyes
Published: January 2022

La educación tradicional ha ido evolucionando de manera paulatina, desde las corrientes pedagógicas hasta los métodos de enseñanza, para convertirse en lo que actualmente conocemos como educación a distancia, introduciendo nuevas tecnologías al salón de clases a través de aulas virtuales, estás traen consigo cambios en los procesos de enseñanza- aprendizaje, convirtiéndolas en modelos dinámicos, donde las evaluaciones formativas y sumativas sirven para desarrollar nuevas habilidades en los estudiantes, fortaleciendo el conocimiento de los distintos niveles educativos. Partiendo de lo anterior es como surge el estudio, del aprendizaje basado en herramientas digitales en el Instituto Tecnológico de Durango (ITD) con los estudiantes de Educación a Distancia (EAD), en la asignatura de Propiedades de los Materiales de la carrera de Ingeniería Industrial, con el objetivo de conocer el impacto que generan estas herramientas sobre el índice de aprobación. Esto llevó a realizar una comparación de años anteriores, con los presentes considerando el uso de las siguientes plataformas Mentimeter, Kahoot y Moodle, cada una con una peculiar características, como son, la primera permite crear presentaciones interactivas, agregar preguntas, cuestionarios y gráficos; la segunda crea cuestionarios de evaluación disponibles para aplicaciones móviles o versiones web; la tercera crea espacios de aprendizajes en línea, mediante cursos, que se generan con recursos y actividades, todas en su modo gratuito.
The roles of the Quasi-Biennial Oscillation and El Nino for entry stratospheric water vapour in observations and coupled chemistry-ocean CCMI and CMIP6 models
Authors: Ziskin Ziv Shlomi , Garfinkel Chaim I. , Davis Sean , Banerjee Antara
Published: January 2022

Abstract. The relative importance of two processes that help control the concentrations of stratospheric water vapor, the Quasi-Biennial Oscillation (QBO) and El Nino-Southern Oscillation (ENSO), are evaluated in observations and in comprehensive coupled ocean-atmosphere-chemistry models. The possibility of nonlinear interactions between these two is evaluated both using Multiple Linear Regression (MLR) and three additional advanced machine learning techniques. The QBO is found to be more important than ENSO, however nonlinear interactions are non-negligible, and even when ENSO, the QBO, and potential nonlinearities are included the fraction of entry water vapor variability explained is still substantially less than what is accounted for by cold point temperatures. While the advanced machine learning techniques perform better than an MLR in which nonlinearities are suppressed, adding nonlinear predictors to the MLR mostly closes the gap in performance with the advanced machine learning techniques. Comprehensive models suffer from too weak a connection between entry water and the QBO, however a notable improvement is found relative to previous generations of comprehensive models. Models with a stronger QBO in the lower stratosphere systematically simulate a more realistic connection with entry water.
Echo state network model for analyzing solar-wind effects on the AU and AL indices
Authors: Nakano Shin'ya , Kataoka Ryuho
Published: January 2022

Abstract. The properties of the auroral electrojets are examined on the basis
of a trained machine-learning model.
The relationships between solar-wind parameters and
the AU and AL indices are modeled with an echo state network (ESN),
a kind of recurrent neural network.
We can consider this trained ESN model to represent nonlinear effects
of the solar-wind inputs on the auroral electrojets.
To identify the properties of auroral electrojets,
we obtain various synthetic AU and AL data by
using various artificial inputs with the trained ESN.
The analyses of various synthetic data show that the AU and AL
indices are mainly controlled by the solar-wind speed
in addition to Bz of the interplanetary magnetic field (IMF)
as suggested by the literature.
The results also indicate that the solar-wind density effect is
emphasized when solar-wind speed is high and when IMF Bz is near zero.
This suggests some nonlinear effects of the solar-wind density.
WAYS OF FORMATION AND DEVELOPMENT OF THE MODERN URBAN LANDSCAPE
Authors: Dolenina Olga Evgenevna , Ternova Natalya Aleksandrovna
Published: January 2022

The analysis of advanced trends in the development of the current modern landscape, the problems faced by modern cities and ways to solve them — allowed us to formulate the main trends in the development of the urban landscape.
RESEARCH OF NORMATIVE-LEGAL BASE OF PERSONNEL FORMATION POLICY OF CIVIL DEFENSE SERVICE
Authors: O. Inozemtseva
Published: January 2022

The article investigates the normative-legal base of formation of personnel policy of the civil protection service in the context of creation and development of the civil protection service of Ukraine. It is determined that the initial fundamental issue of systemic targeted reforms and the creation of an effective service to protect the population from emergencies is the introduction of modern methods, norms and requirements in the formation of personnel policy of the service
Populism and Bureaucratic Frictions: Lessons From Bolsonarism
Authors: Peci Alketa
Published: January 2022

How do populist governments approach public bureaucracies? Here we reflect on the rise of Bolsonarism as a form of populism in the Brazilian context and on its relationship with public bureaucracies. Bolsonaro’s “strategy of governing” builds on an unstable coalition that combines neoconservatism, market-oriented economic approach and military nationalism and corporativism. We analyze how the antagonism at the center of this coalition shapes bureaucratic strategic positions and defend an understanding of Bolsonarism as an ideology of contentious governing that nurtures divisive bureaucracies.
The Effect of Liquidity, Thin Capitalization, Capital Intensity, and Earnings Management on Tax Avoidance in Manufacturing Companies Listed in Indonesia Stock Exchange (IDX) 2010-2020 Period
Authors: Aisyah Rika Nisma , . Erlina , Erwin Keulana
Published: January 2022

This study aims to determine the effect of liquidity, thin capitalization, capital intensity, and earnings management on tax avoidance in manufacturing companies listed on the Indonesia Stock Exchange (IDX) for the 2010-2020 period. The type of research used is descriptive quantitative. The research sample used was 34 companies from 184 companies. The sample return method used is the selection of samples for research from the research population by fulfilling several predetermined criteria (purposive sampling). The data type used is secondary data, and the data analysis technique is a multiple linear regression test using Eviews 9 software. The proxy used for tax avoidance is the book-tax difference (BTD). The results of this study indicate that liquidity and earnings management have a positive and significant effect on tax avoidance. Meanwhile, thin capitalization and capital intensity do not affect tax avoidance.

Keywords: Tax Avoidance, Liquidity, Thin Capitalization, Capital Intensity, Earnings Management.
Theoretical Astrophysics in the Byurakan Observatory (1946 - 2021)
Authors:   NAS RA V. Ambartsumian Byurakan Astrophysical Observatory (BAO), Armenia, Nikoghossian A. G.
Published: January 2022

The purpose of this review is to give a general idea of the results on theoretical astrophysics investigations carried out at the Byurakan Observatory during the period of its existence. A special place in the review is given to the research work in the Department of "Theoretical Astrophysics", founded in 1965. The review consists of two parts. The first part is mainly devoted to works on the theory of radiation transfer somehow related to Ambartsumian's ideas developed in his fundamental studies of the 40-50s of the last century. The second part presents, on the one hand, the results which are of importance for theoretical physics in general and, on the other hand, gives their application to the interpretation of observational data of various cosmic objects. In order to get an idea of the importance of each result, the background and prerequisites of the research are given, indicating its significance from the point of view of astrophysics. Naturally, the most important results are presented in more detail. At the same time, the review in one way or another includes almost all of the most important results obtained by various members of the department at different times. It should be noted that works on some other areas of theoretical astrophysics are not included in the review, since they are presented in other reviews of this series.
A new look at some aspects of geometry, particle physics, inertia, radiation and cosmology
Authors:   NAS RA V. Ambartsumian Byurakan Astrophysical Observatory (BAO), Armenia, Ter-Kazarian G.
Published: January 2022

Continuing along the line of our previous report (Ter-Kazarian, 2021a), in present communication we briefly outline several closely related issues, carried out also in Byurakan Astrophysical Observatory, not touched in it for brevity reasons. These issues reveal and further develop novel aspects of the fundamental nature and structure of the space-time geometry and the high energy physics, the inertia effects, the intense radiation physics, and the notion of relative velocity in a curved space-time.
Twenty years of the Armenian Astronomical Society (ArAS)
Authors:   NAS RA V. Ambartsumian Byurakan Astrophysical Observatory (BAO), Armenia, Mickaelian A. M. , Farmanyan S. V. ,   NAS RA V. Ambartsumian Byurakan Astrophysical Observatory (BAO), Armenia, Mikayelyan G. A. ,   NAS RA V. Ambartsumian Byurakan Astrophysical Observatory (BAO), Armenia
Published: January 2022

A review on the activities and achievements of the Armenian Astronomical Society (ArAS) and the Armenian astronomy in general is given on the occasion of the 20th anniversary of the official foundation of ArAS. ArAS membership, ArAS electronic newsletters (ArASNews), ArAS webpage, Annual Meetings, Annual Prize for Young Astronomers (Yervant Terzian Prize) and other awards, international relations, participation in international organizations, Byurakan International Summer Schools (BISS), regional and local schools, Byurakan science camps, astronomical Olympiads and other events, other matters related to astronomical education, astronomical heritage, amateur astronomy, astronomy outreach and ArAS further projects are described and discussed.
Uluslararası Hukuk ve İnsan Hakları Açısından Keşmir’in Hindistan’dan ‘Ayrılma Hakkı’
Authors: ARAL Berdal
Published: January 2022

Bu çalışmada, öncelikle, İngiliz sömürge yönetiminin çekilmesi sürecinde Keşmir’in Hindistan’a bağlanmasına giden sürecin hukuken ‘sorunlu’ olduğu ileri sürülmektedir. Hindistan yönetimi altında nüfusun büyük çoğunluğunu Müslümanların oluşturduğu Keşmir halkının, hem Soğuk Savaş döneminde iki farklı durum için söz konusu olabilen, hem de Soğuk Savaş sonrası dönemde egemen devletler içinde yaşayan ‘halk’lar için geliştirilen ‘yeni’ doktrin çerçevesinde, Hindistan’dan ayrılma hakkına sahip olduğu ifade edilmektedir. Keşmir halkının özgürlük mücadelesi, bağımsızlık hakkına cevaz veren her üç self-determinasyon tipolojisine de uygun görünmektedir: birincisi, sömürge yönetimi altında yaşayan halkların bağımsızlık hakkı; ikincisi, yabancı bir gücün silahlı işgali altında yaşayan halkların bağımsızlık hakkı; üçüncüsü, sınırları içinde yaşadıkları devletin sistematik dışlamasına ve onları hedef alan insanlık suçlarına maruz kalan halkların ‘son çare’ olarak ayrılma hakkı.
Synthesis and Evaluation of Some Novel 6-Substituted Quinazoline Derivatives as Antitumor Agents
Authors: Hai guan Ding Hai guan Ding , Zhi qiang Cai Zhi qiang Cai , Ling Hou Ling Hou , Zhi quan Hu Zhi quan Hu , Zheng sheng Jin Zheng sheng Jin , Di Xu Di Xu , Hui Cao Miao miao Meng Hui Cao Miao miao Meng , Yu Hui Xie Yu Hui Xie , De qiang Zheng De qiang Zheng
Published: January 2022

A series of novel 6-substituted quinazoline derivatives were synthesised as epidermal growth factor receptor(EGFR) and Human epidermal growth factor receptor 2 (HER2)inhibitors in our lab. The novel compounds were measured for their dual enzyme inhibition as well as their cytotoxic activity on MCF7 cell line. The results revealed that all the compounds showed inhibition of both enzymes. Compound 5c showed the best inhibitory activity against both enzymes and IC50 of its was 2.6 nM against EGFR kinases and 4.3 nM against HER2 kinases, respectively. Most of the measured compounds showed to antitumor activity on MCF7.
Thermal Properties of Acylated Low Molecular Weight Chitosans
Authors: Shu Xian Tiew and Misni Misran Shu Xian Tiew and Misni Misran
Published: January 2022

Acylated low molecular weight chitosans (LChA) were prepared from nucleophilic acylation of chitosan using acid anhydrides of short and medium chain length (4 - 10) to study the response of applied heat as a function of acyl chain length. Thermogravimetric analysis (TGA) revealed the decomposition of LChA consisted of glucosamine and acyl-glucosamine units around 141 - 151and#176;C to 400 - 410and#176;C. Both TGA and differential scanning calorimetry (DSC) analyses indicated that the introduction of acyl groups disrupted the hydrogen bonding of chitosan, the effect was more prominent as the degree of substitution and chain length of LChA increased. Grafting of acyl chains lowered the kinematic viscosity of LChA as the disruption of hydrogen bonding led to decreased hydrodynamic volume. Field emission scanning electron micrographs showed that LChA with longer chains having larger particle size due to bigger occupancy volume of acyl chains during spray drying.
Optimization of Production Parameters of Tobacco Seed Oil Methyl Ester using Multi-Response Taguchi Method and MANOVA
Authors: H lya Karaba H lya Karaba , Semra Boran and Harun Resit Yazgan Semra Boran and Harun Resit Yazgan
Published: January 2022

There is a growing recognition that using of biodiesel in large commercial systems based on sustainability, existing resources and residues can help to natural resources. Tobacco seed oil (TSO) is also used for biodiesel production as a non-edible vegetable oil. A crude oil was obtained from tobacco seeds (TS) and then tobacco seed oil methyl ester-TSOME (biodiesel) was obtained by a transesterification process. In this study, we aimed to achieve optimal biodiesel properties based on different factors using multi response Taguchi method and multivariate analysis of variance (MANOVA). The purpose of the process was to meet a European Biodiesel Standard EN 14214. Properties of the biodiesel (responses) were determined as methyl ester quantity, kinematic viscosity, density, flash point of methyl ester and freezing point of methyl ester. The factors (production parameters) were chosen such as catalyst type, alcohol/oil molar ratio, reaction temperature and catalyst amount for experiment design. The factors that influenced the desired properties were determined using MANOVA. The factors’ level was obtained using a multi response Taguchi method. We found that catalyst type and catalyst amount have a significant effect on the responses and their levels must be level 1(KOH) and level 3 (1.5%) respectively. Thereby the methods provided to produce biodiesel meet requirements of the standard with minimum cost and in short time.
Modelling for Gas Transport in Enhanced Polymeric Blend Membrane
Authors: Asim Mushtaq Asim Mushtaq , Hilmi Mukhtar and Azmi Mohd Shariff Hilmi Mukhtar and Azmi Mohd Shariff
Published: January 2022

The main aim of this research work is to develop a model of carbon dioxide (CO2) separation from natural gas by using membrane separation technology. This study includes the transport mechanism of the porous membrane. The fundamental theories of diffusion, poiseuille (viscous) flow, Knudsen diffusion and surface diffusion are used. The developed model of incorporating three diffusion mechanisms to be modified for modeling of polymeric blends towards membrane selectivity and permeability. For the purpose of assessing the gas permeance using the theoretical models, the experimental data taken from CO2 permeance in the PSU/PVAc (85/15) wt. % /DEA enhanced polymeric blend membrane was considered. The results obtained from modified Cho Empirical model of total gas permeance showed the least error as compared to other models. The modified Cho Empirical mathematical models were extended by blending factor to predict CO2 gas molecule transport in Enhanced Polymeric Blend Membrane (EPBM) to obtain precise theoretical values that are close to the experimental values. The Extended modified Cho Empirical model validation demonstrated the ability to predict CO2 permeance with reasonable accuracy.
Silicon Carbide Effect as Reinforcement on Aluminium Metal Matrix Composite
Authors: Ali Dad Chandio Ali Dad Chandio , Muhammad Basit Ansari Muhammad Basit Ansari , Shahid Hussain Shahid Hussain , Muhammad Ali Siddiqui Muhammad Ali Siddiqui
Published: January 2022

In the present study aluminium silicon carbide (Al/SiC) composites were prepared by powder metallurgical method. The mechanical and morphological evaluation were studied upon the variation of reinforcements percentages i.e.10, 15 and 20 wt.% of SiC powder were used as the reinforcements in aluminium matrix. The comparison of powder metallurgy method with stir casting method of Al/ (SiC) composites preparation was performed and the particle reinforcements were visualized through Scanning Electron Microscopy (SEM). The results demonstrated increased hardness with increasing wt. % of SiC particles. This was attributed to efficient stress transfer and dislocation strengthening. In addition, the densification behaviour of the composites was also studied and SiC particulates were found to exhibit profound effect on composites density.
Analysis of Current Trends in the Development of DSLs and the Possibility of Using them in the Field of Information Security
Authors:   Armed Forces Academy of General M. R. Štefánik, Harnoš Patrik , Dedera Ľubomír ,   Armed Forces Academy of General M. R. Štefánik
Published: January 2022

Use of an appropriate DSL can significantly reduce development time. This is due to the fact that DSLs are limited to the use of terms relating to the explicit domain, which makes them much easier for programmers to understand and learn. Despite these and other advantages of DSLs over GPLs, programmers will only exceptionally turn to DSLs in development process. Therefore, in this article, we will look closer on what DSLs are, when it is appropriate to use them in a project and when not. In the last part of this article, we will focus on the possibilities of using DSLs in the field of information security.
Comparing best-worst method and full consistency method in a fuzzy environment
Authors: Haqbin Arash
Published: January 2022

Multicriteria Decision Making (MCDM) is one the most important branches of decision theory. Due to the fact that MCDM methods have the utmost significance in management, scholars try to develop more MCDM methods. Since calculating the weights of criteria is an important step in any MCDM method, increasing the accuracy of weight calculating methods can highly affect these methods. This accuracy can be improved by less pairwise comparison between criteria. To this end, the present study seeks to make a comparison between two new weight calculating techniques, namely BWM and FUCOM in a fuzzy environment using a real-world case study Results of this study shows that FUCOM-F provides more reliable results compared to FBWM since its consistency is less than FBWM by a great amount.
Hybrid and adaptive harmony search algorithm for optimizing energy efficiency in VMP problem in cloud environment
Authors: Adamuthe Amol C. , Kagwade Smita M.
Published: January 2022

Data Center energy usage has risen dramatically because of the rapid growth and demand for cloud computing. This excessive energy usage is a challenge from an economic and environmental point. Virtual Machine Placement (VMP) along with virtualization technologies is widely used to manage power utilization in data centers. The assignment of virtual machines to physical machines affects energy consumption. VMP is a process of mapping VMs onto a set of PMs in a data center to minimize total power consumption and maximize resource utilization. The VMP is an NP-hard problem due to its constraints and huge combinations. In this paper, we formulated the problem as a single objective optimization problem in which the objective is to minimize the energy consumption in cloud data centers. The main contribution of this paper is hybrid and adaptive harmony search algorithm for optimal placements of VMs to PMs. HSA with adaptive PAR settings, simulated annealing and local search strategy aims at minimizing energy consumption in cloud data centers with satisfying given constraints. Experiments are conducted to validate the performance of these variations. Results show that these hybrid HSA variations produce better results than basic HSA and adaptive HSA. Hybrid HS with simulated annealing, and local search strategy gives better results than other variants for 80 percent datasets.
A Flavonoid compound of Turbinaria decurrens Bory with The Potential Antioxidant and Anticancer Activity
Authors: Jumaetri Sami Fitriyanti , Hariani Soekamto Nunuk , Okino Tatsufumi , Firdaus Firdaus , latip Jalifah
Published: January 2022

Isolation and characterization of quercetin flavonoid compound from Dutungan Island, South Sulawesi Province, Indonesia has been successfully done from ethyl acetate extract. Extraction method used maceration, isolation used chromatography, anticancer activity with MTT method and antioxidant test used DPPH radical. Structure was discussed with the FT-IR, NMR spectrophotometer and compared with the literature. Total flavonoids from ethyl acetate extract were 4.8 mgEQ/g, IC50 value of antioxidant activity was 4.23 μg/ml using the DPPH method (2,2-diphenyl-1-picrylhydrazyl), and anticancer activity of H460 cells IC50 value was 10.95 μg/ml. The quercetin compound is potential as an anticancer and was first report in the T. decurrens Bory species.
Development of a combined solution of pyrimidine
nucleotides with vitamin B6
Authors: Almakaiev M. S. , Dvinskikh N. V. , Almakaieva L. G. , Kryvanych Olga V.
Published: January 2022

Pyrimidine nucleotides, namely uridine monophosphate and cytidine monophosphate, play an important role in the cellular metabolism of nerve fibers. The combination of these nucleotides with pyridoxine hydrochloride (vitamin В6) in one dosage form will allow us to fully implement the strategy of the complex neurotropic pharmacotherapy in neuropathies of various origins. To develop a stable solution, an important step at the stage of the composition development is to study the compatibility of active substances (active pharmaceutical ingredients - APIs) in solution. Samples of binary solutions and solutions containing all active substances were prepared and examined. The API interaction was determined by various parameters – changes in color, transparency, рН, the total impurity content, etc. Based on a comprehensive study of the processes of the API dissolution the optimal pH limits of the solution required for the stable existence of a combination of substances with different pH values of the medium have been substantiated and experimentally confirmed. As a result of the research, the optimal pH value of the solution recommended is 4.0-4.8. In the composition of substances the amount of water can be in an adsorbed or crystallized, or combined form. This fact should be taken into account in order to correctly calculate the actual amounts of initial ingredients when preparing the solution. The nature of the water component of APIs was clarified when studying the phase composition of samples on a powder diffractometer. The studies conducted have allowed us to determine the directions of further research for developing the composition of an injection drug. This research is in choosing the optimal buffer system and excipients-antioxidants.
Assessment of the convergence angle of teeth prepared for full crown by preclinical dental students
Authors: Al-Sammarraie Amaweya Abdulrahman , Abdulkareem Ayyam Khalid , Rateb AlAridi Hadeel , Fayez Hammad Rahel , Yousef Shehadeh Duaa
Published: January 2022

The objective of this study was to measure the buccolingual and mesiodistal convergence angles of six typodont teeth (# 26, 36, 45, 15, 21, and 13), prepared by preclinical dental students at Ajman University, for porcelain fused to a metal full crown and to compare them with the recommended convergence angle (6.5°). Additionally, we sought to compare the angles recorded for the six sets of teeth and relate the results according to the tooth position and surface and to know which one shows the greater tendency of straying from the normal convergence angle. Materials and methods: The angle of convergence of one hundred ninety-eight typodont teeth preparations was measured both buccolingually and mesiodistally by using a Dino-lite pro digital microscope (AM-413ZT Taiwan) with a Dinocapture (2.0 version 1.5.27.A, AnMo Electronics Corporation). All the results were recorded, and the data were analyzed by means of a one-sample t-test and one-way ANOVA. Results: The mean total convergence angle for this study was 11.29°± 6.66° from both surfaces, which is greater than the recommended value of 6.5° and statistically significant (p<0.000). Only 7.07% of teeth met the ideal convergence angle from both surfaces, and the one-sample test showed a statistically significant difference (p<0.057) from the recommended convergence angle, except for the mesiodistal convergence angle of the lower-right second premolar, which revealed no significant difference. The mean convergence angle for the buccolingual surface was 12.42°± 6.16°, which was higher than that of the mesiodistal surface (10.16°± 7°). One-way ANOVA showed a significant difference between all selected teeth (p<0.000), and a paired samples t-test showed a significant difference within two teeth only, the lower-right second premolar and upper-right canine (p<0.000), in which the mesiodistal measurement showed a lower convergence angle than the buccolingual angle. Conclusions: Preclinical students prepared teeth with a convergence angle higher than the recommended convergence angle. However, all the recorded angles were within the range of previous studies. It was concluded that the recommended convergence angle was difficult to achieve in preclinical practice.
Optimization of phenolics and antioxidants extraction from Centaurium erythraea using response surface methodology
Authors: Zam Wissam , Ali Ali , Saleem Dimah , Alali Sahar
Published: January 2022

In recent years, Centaurium erythraea extracts have attracted much research attention in the context of prevention or treatment of many diseases due to its bioactive compounds content and antioxidant activity. The antioxidants of C. erythraea are very effective as they possess excellent antioxidant activity. Thus, it can be used as a safe and natural food preservative. The aim of this study is to make extracts more effective by optimizing the extraction conditions of the phenolics and antioxidants from C. erythraea using response surface methodology (RSM) based on a central composite design (CCD). Two process variables (Methanol volume fraction and solid - solvent ratio) were evaluated at five levels (13 experimental designs). Multiple regression analyses were performed to obtain quadratic polynomial equations using RSM; each response was fitted by a quadratic model. The adequacy of the models was proven using the analysis of variance (ANOVA). The significant effects of the factors and their interactions on the extraction efficiency were investigated at 95% confidence interval. RSM indicated that the optimal extraction conditions were 71% methanol volume fraction and 2.2:10 solid:solvent ratio. Predicted values thus obtained were close to the experimental values indicating suitability of the model.
Evaluation of an Ayurvedic preparation-‘Ekangaveera Rasa' for possible metal toxicity: Behavioral, Biochemical and Histopathological Analysis
Authors: Sumalatha Suhani , Tantri Gururaj , Shreshta Jessica , Shetty Ashwija , Nayak Vanishree S , Prabhath Sushma
Published: January 2022

Ayurveda, an ancient Indian medicinal system, is highly regarded as complementary and alternative medicine in recent years. However, there are reports to show the toxic effects of specific Ayurvedic preparations, which use metals as an ingredient in them. One such medicine is 'Ekangaveera Rasa' This herbo-minero-metallic preparation is used to treat the pain of neurological origin. Therefore, the present study aimed to evaluate the possible alteration caused by Ekangaveera Rasa on the brain, liver, and kidneys by histological, biochemical, and behavioral analysis. For this evaluation, Wistar rats were divided into four groups: Group 1- normal control; group 2, 3 and 4 were treated with Ekangaveera Rasa at doses of 120, 240 and 600 mg/kg bodyweight for 30 days. Behavioral parameters were assessed on the 15th and 30th day by using the passive avoidance test. At the end of the treatment period, blood was collected and subjected to the basophilic stripling and biochemical analysis. Tissues were processed for histopathological evaluation. The histopathological, biochemical, and behavioral analysis did not show any harmful effect, thereby rendering Ekangaveera Rasa nontoxic and further glorifying the healing benefits of Ayurveda.
A rare entity of malignant insulinoma diagnosed after 30 years of clinical manifestation of hypoglycemia: A case report and literature review
Authors:   Department of General Surgery, Saint Georges Hospital University Medical Center, Beirut, University of Balamand, Lebanon., Abdel Backi Saleem , Saber Toufic ,   Department of General Surgery, Saint Georges Hospital University Medical Center, Beirut, University of Balamand, Lebanon., Rassi Ziad el ,   Head of General Surgery Department, Saint Georges Hospital University Medical Center, Beirut, University of Balamand, Lebanon
Published: January 2022

Malignant insulinomas, a rare life threatening pathology, exists in literature as an entity that constitutes 10% of all insulinomas and often present as multi-centric macro nodules with multiple lymph nodes or liver metastases before diagnosis. We report a rather rare case of a 68 year old male with a 30 years history of uninvestigated severe hypoglycemic attacks that improved on glucose intake. Blood tests showed a decreased value of glycemia (45 mg/dL) associated with increased insulin level (54 μU/ml) and an increased glycemia/ insulinemia ratio of 0.83 supporting the diagnosis of insulinoma. Abdominal CT showed a 4 cm mass localized in the head of the pancreas with atrophic body and tail, no signs of distant metastatic disease. A concomitant diagnosis of primary hyperparathyroidism raised, based on elevation of calcium associated and high level of PTH. The coexistence of the two endocrinopathies suggested the presence of type 1 multiple endocrine neoplasia (MEN I). Based on the workup suggesting a benign insulinoma with no signs of metastatic disease, co-existing with debilitating symptoms of hypoglycemia, pancreatectomy with lymph node dissection was performed. Histo-pathological examination returned surprisingly positive for malignant neuro-endocrine tumor with positive lymph nodes. In that domain, we summarized the literature discussion of neuroendocrine tumors, elaborating on malignant insulinoma diagnosis and management. Furthermore, what our article is trying to lay upon existing literature is a case of a long standing existent MEN 1 malignant insulinoma manifesting as a remarkably slow progressive disease of 30 years’ timeline versus a less likely chance of a transformation from benign insulinoma to malignant Keywords: neuroendocrine neoplasm; pancreatectomy; MENI; malignant insulinoma; chronic hypoglycemia.
Bone metastases from renal cell carcinoma: A case report and literature review
Authors:   Faculty of Medicine of Tunis, Department of Orthopedic Surgery, Mongi Slim Marsa University Hospital, Tunis, University of Tunis El Manar, Tunisia., Nefiss Mouadh
Published: January 2022

Management of bone metastases from Renal Cell Carcinoma (RCC) has significantly changed after the era of targeted therapy that improved the overall survival. This has sucked the different interveners in their management to push the surgical indications in order to improve outcome and quality of life for these patients. In case of a solitary metastasis or a limited number of resectable metastases wide resections have to be considered according to patient profile, comorbidities, localization, heaviness of the surgery and to benefit –risk balance. However such surgeries are highly demanding procedures that must be carefully planned and discussed in multidisciplinary team and with patient. Thus, surgical decision-making for a second metastasis and according to what criteria remains a subject of controversy. We report a case of an aggressive metastatic renal cell carcinoma with good functional and oncologic outcomes 3 years after surgery coupled with anti-angiogenic treatment. A review of the literature concerning recent attitudes in the management of bony metastatic renal carcinoma was carried out. Keywords: renal cell carcinoma; bone metastases; surgery; targeted therapy.
Epidemiología e interculturalidad
Authors: Romero Palmera José Antonio
Published: January 2022

La epidemiología se encarga del estudio y la frecuencia de las enfermedades y los eventos de la salud, y por su parte la interculturalidad estudia las relaciones de intercambio y comunicación igualitario entre grupos culturalmente diferente desde el punto de vista étnico de lengua de nacionalidad entre otros es de vital importancia para establecer un modelo intercultural de salud conocer los componentes
Resistencia antibiótica de Escherichia coli y Staphylococcus saprophyticus en la infección urinaria de un hospital público
Authors: Raraz-Vidal Jarvis , Allpas-Gomez Henry , Raraz-Vidal Omar
Published: January 2022

Introducción: La resistencia de antibióticos puede llegar a causar una amplia morbilidad y complicaciones. Objetivo: Determinar el perfil de resistencia antimicrobiana de Escherichia Coli y de Staphylococcus Saprophyticus, en pacientes con infección urinaria hospitalizados en el servicio de Medicina Interna del Hospital Municipal Los Olivos. Métodos: Estudio descriptivo, retrospectivo de corte transversal. Se realizó en el servicio de Medicina Interna del Hospital Municipal los Olivos (HMLO). Participantes: historia clínica de pacientes hospitalizados con infección urinaria en el servicio de Medicina Interna. Intervenciones: Según los criterios de inclusión y exclusión se obtuvieron, 96 historias clínicas (HC) del año 2013. Se utilizó un instrumento de recolección validado. Se realizó el análisis descriptivo con software estadístico STATA versión 25. Resultados: De las 96 HC, la edad promedio fue 55,04 años, los agentes microbianos más frecuentes fueron: la Escherichia coli con 85,3%, Staphylococcus saprophyticus 4.2% y Klebsiella pneumoniae 3,1%. La prevalencia de productores de betalactamasa espectro extendido (BLEE) fue 10,4%. Los antibióticos más resistentes fueron: trimetoprim/sulfametoxazol 89,6%, ampicilina 86%, piperacilina 84,6%, tetraciclina 79,2% y ciprofloxacino 70,8%. Los antibióticos más sensibles fueron: amikacina 100%, imipenem 100%, ertapenem 98%, meropenem 96% y piperacilina/tazobactam 96%. Conclusión: El uropatógeno más frecuente en pacientes con ITU hospitalizados fue la E. coli. Los antibióticos que presentaron resistencia a la E. coli fueron: trimetoprim/sulfametoxazol, ampicilina, piperacilina, tetraciclina y ciprofloxacino, y para el S. Saprophyticus fueron: amoxicilina/ ácido clavulánico, trimetoprim/sulfametoxazol, ceftriaxona y ciprofloxacino.
Sistema de gestión TO-BE: garantizar el derecho a la salud de pacientes con ITS en Perú
Authors: Landeo Quispe Alex Sandro , Orihuela Rojas Vladimir , Orihuela Rojas Fernando Pool , Almidón Ortiz Carlos Alcides
Published: January 2022

Se realizó una investigación de campo para conocer la gestión de los procesos de solicitud y admisión de citas médicas, considerando la estigmatización y discriminación de las personas ITS, con el fin de garantizar el derecho a la salud de estos pacientes en Perú. Se ejecutó la sistematización de la información sobre los procesos y mecanismos de exigibilidad, bajo los lineamientos y manuales de los cuatro procesos estratégicos del MINSA contemplados para el otorgamiento de citas médicas, siguiendo los lineamientos de Gob.Pe, Adicionalmente, mediante verificación de los procesos se construyeron la matriz entidad-relación de la gestión por procesos del SSP, y el flujograma del proceso de solicitud y otorgamiento de citas AS-ISS. Se consideraron aspectos tecnológicos-médicos-legales con la participación de 201 pacientes independientemente del motivo o patología a consultar, identificando incidentes en la eficiencia del proceso misional. Por último, se implementó el flujograma de procesos de reserva de citas médicas a través de la aplicación ejecutable para smartphones, tabletas y otros dispositivos móviles (APP) TO-BE la cual conlleva a 10 pasos desde el registro de usuario hasta la emisión de comprobante de otorgamiento de cita médica. Se analizaron las preferencias de los usuarios sobre las causas superables en el proceso misional, mediante una encuesta estructura a 170 usuarios de SSP.
Rectal metastasis in Lung cancer: A case report and review of the literature
Authors: Huy Trinh Le , Manh Pham Duy
Published: January 2022

Gastrointestinal metastasis in lung cancer is not commonly encountered clinically, of which rectal involvement is a sporadic event. There were few reports about rectal metastasis in lung cancer. All of them had a dismal prognosis. We report a case of synchronous rectal metastasis in a lung cancer patient with a different clinical scenario, treatment, and prognosis. The patient presented with infrequent hematochezia due to a rectal mass confirmed as adenocarcinoma on core biopsy. Computer tomography showed many nodules in both lungs, which raised the initial diagnosis of pulmonary metastasis in rectal cancer. However, we decided to perform immunohistochemistry on the rectal biopsy specimen, which, surprisingly, revealed the site of origin was from the lung. Subsequently, next gene sequencing was performed and detected an exon 19 deletion on the EGFR gene. Though he had infrequent hematochezia, we decided to treat him with Erlotinib (a first-generation TKI) and closely monitored the rectal symptoms. Six months later, he achieved a complete response of both lung and rectal lesions. At present, he has been progression-free for 14 months. Thus, physicians should always be aware of this differential diagnosis in synchronous tumors and carefully consider the optimal treatment to start.
Prevalence and related factors of alcohol consumption among ethnic minority boarding high schoolers in Southern Vietnam
Authors: Binh Nguyen Thanh , Trinh Le Thi Diem , Quang Pham Duy , Bich Nguyen Ngoc , Kich Dieu
Published: January 2022

Hazardous levels of alcohol use have caused many diseases, posing a great economic and social burden to the community. Alcohol use in some provinces of Vietnam shows that alcohol consumers are getting younger and younger. This study aimed to determine the proportion of alcohol consumption among students at Binh Phuoc Ethnic Minority High School in 2020 and a number of factors leading to the alcohol consumption. The result showed that the alcohol use proportion in the past 12 months was 62% and the risky drinkers rate was 11.2%. Some factors concerning the use of alcohol among students such as gender, age, grade level, behavior, smoking, alcohol use family members, alcoholic friends, and friends influence were also revealed in the study.
El sistema de costeo ABC, herramienta de gestión empresarial: una revisión teórica y sistemática
Authors: Vásquez Campos Salomón Axel , Quispe Morales Cesia Nicoll , Gonzales Villar David Yonatan , Hilario Panduro Zaida Jackeline
Published: January 2022

El objetivo de este estudio fue analizar el sistema de costes ABC: instrumento de gestión empresarial facilitando la información relevante sobre los conocimientos teóricos prácticos: la base para tomar decisiones. El estudio corresponde a un enfoque cualitativo, de revisión bibliográfica, cuya técnica utilizada fue el análisis documental. Los resultados cualitativos dejan la evidencia del análisis del sistema de costes por actividades, facilitando eficazmente la planeación, organización y control en una empresa; porque la información sobre los costos es fundamental para el buen funcionamiento. Por otro lado, este sistema de costos genera una amplia cosmovisión para beneficio de la empresa: consumo de recursos, desembolso al momento de la elaboración de un producto y toma de decisiones. Se concluye que la aplicación de este sistema siempre será una ventaja comercial ya que esta herramienta es considerada como una estrategia para ayudar al crecimiento de una organización, por medio del control de sus costos de producción.
El control interno: una evaluación de los procesos, en las pollerías del distrito de Chaclacayo
Authors: Sánchez Bembino Samuel , Felix García Jhan Carlos , Vásquez Campos Salomón Axel
Published: January 2022

El presente estudio tuvo por objetivo determinar la situación del control interno en las pollerías del distrito de Chaclacayo. El estudio se realizó con un enfoque cuantitativo, de tipo descriptivo, de un diseño no experimental y transversal. Para la recolección de los datos se usó un cuestionario que se aplicó a 16 personas de la misma cantidad de pollerías. El estudio llegó a la conclusión de que en el distrito del Chaclacayo un 16.7% que negocios del Régimen Especial de Renta no cuenta con un control interno adecuado, a diferencia de las pollerías pertenecientes al Régimen Mype Tributario y al Régimen General, exponiendo la evidencia de que el control interno en los negocios tiene mayor nivel cuando los negocios son más grandes.
“NOMINA NUDA TENEMUS”?CONSIDERAZIONI SU FIGURE DIVINE E ICONOGRAFIE A PARTIRE DA ALCUNE TERRECOTTE VOTIVE DELL’AREA SACRA DEL KOTHON A MOZIA
Authors: Chiarenza Nicola
Published: January 2022

This paper considers the terracottas discovered in the Sacred Area of the Kothon at Motya during the excavations ofthe Sapienza University of Rome expedition to Motya in 2005-2008. The analysis of the finds allowsus to investigate the possible correlations between the iconographies of the Greek-type terracottasand the Phoenician deities that were worshipped in this sacred area. On a further level of analysis this study attempts at looking beyondthe names of the characters depicted in the terracottas, by offering some remarks on religious phenomena taking place in Motya as a result of the interaction between different cultural traditions
Recent Advances on Pharmacology and Chemistry of Pycnanthus angolensis over the last decade (2012-2021)
Authors: Sikam Klev Gaïtan , Dzouemo Liliane Clotilde , Happi Gervais Mouthé , Wansi Jean Duplex
Published: January 2022

Pycnanthus angolensis, widely known under its trade name "ilomba", is a medicinal plant from the family Myristicaceae that has occupied a prominent place in African traditional medicine for several decades; its broad application to treat numerous diseases, including malaria, bacterial infections and most recently COVID-19. The various chemical studies undertaken on the plant identified many classes of specialized compounds, including quinone-terpenoids, lignans and isoflavonoids, as the most abundant and bioactive components. The plant is defined as a major asset in developing new potent drugs and deserves further investigation in this regard. This mini-review aims to compile the newly documented findings on the traditional uses, phytochemistry and pharmacology of P. angolensis over the last decade from 2012 to 2021. In this regard, a literature search using the keyword Pycnanthus has been done without language restriction in numerous online libraries, including Scifinder, PubMed, Google Scholar, and only papers on Pycnanthus angolensis published after 2011 have been exploited during the writing.
Ponte estaiada ou trincheira: qual a melhor solução sob a ótica da gestão pública para Curitiba (Paraná)?
Authors: Oliveira Jairo , Freitas Junior Pedro , Silva Frederico , Albertin Ricardo , Fonseca Danielle
Published: January 2022

A crise da mobilidade urbana está cada vez mais presente na rotina das grandes cidades brasileiras, e dentro desse tema, realizou-se uma pesquisa ex post facto, analisando a obra executada na Avenida das Torres (Curitiba - PR), cuja finalidade era melhorar o tráfego entre o centro da capital para o aeroporto (São Jose dos Pinhais). Para tal obra, foi construída uma ponte estaiada e uma trincheira ao longo da avenida, objetos de análise do presente estudo. Realizou-se uma comparação entre dois tipos de construção. Assim, norteou-se a seguinte questão: qual seria o melhor custo benefício para a Gestão Pública? Viadutos e trincheiras promovem maior fluidez ao tráfego motorizado em ambientes urbanos em comparação às pontes estaiadas que, apesar da mesma função, geralmente são utilizadas para superar grandes distâncias, como em rios, que necessitam espaço para passagem de embarcações; podendo também ser utilizadas em espaços mais curtos, elevando muito o seu custo. Ao final da coleta de dados, verificou-se a grande disparidade orçamentária entre as duas obras referenciadas, onde o viaduto Estaiado custou quase nove vezes mais que a trincheira da Rua Guabirotuba, confirmando a hipótese levantada.
KAZAKHSTAN'S MARKET POSITIONS WITHIN THE EAEU
Authors: САРСЕМБАЕВА А.М.
Published: January 2022

В данной статье рассмотрена проблема реализации процесса регистрации медицинских изделий в рамках ЕАЭС. Проанализирован рынок аккредитованных лаборатории, способных проводить испытания для дальнейшего процесса регистрации. А также стоит обратить внимание на нехватку лабораторий, способных проводить различные испытания на безопасность медицинских изделий в Казахстане в рамках ЕАЭС.

This article discusses the problem of implementing the registration process of medical devices within the EAEU. The market of accredited laboratories capable of conducting tests for the further registration process is analyzed. And it is also worth paying attention to the shortage of laboratories capable of conducting various tests for the safety of medical devices in Kazakhstan within the framework of the EAEU.