bluuebunny/crossref_metadata_2025 huggingface dataset:
Design and ergonomic evaluation of a new adapted endoscope holder to reduce muscle pressure and discomfort during endoscopy
Authors: Ghasemi Mohamad Sadegh , Siadat Morteza , Abdulrazak Bessam , Dehghan Naser , Ibarra-Mejia Gabriel , Forogh Bijan
Published: February 2023

BACKGROUND: Laparoscopic surgeons who regularly perform endoscopy are more likely to develop musculoskeletal disorders than other internal medicine specialists, a difference that attributed to repetitive movements, poor postures, and sub-optimal equipment design. OBJECTIVE: This study aimed to design, build, and evaluate an endoscope holder for reducing the static load applied by the weight of the endoscope, in order to reduce musculoskeletal disorders risk factors in the surgeon’s hand, shoulder and back issues regions. METHODS: A new endoscope holder was designed according to ergonomic design principles. The designed holder was evaluated by surface electromyography (sEMG) and discomfort assessment including 15 laparoscopic surgeons. The results were analyzed with centrality statistics and compared with the independent t-test using SPSS version 22. RESULTS: The evaluation of the new endoscope holder shows a statistical significant decrease in the average electrical activity of biceps brachii, triceps brachii, lateral deltoid, T9 Thoracic erector spinae, L4 Lumbar erector spinae, and external oblique after using the holder (p < 0.05). CONCLUSION: The results shows that using the new endoscope holder is associated with a lower level of discomfort, as well as a lower induced muscle activity. The results also highlight the need to upgrade the holder to offer rotability in all directions (perpendicular to the ground) which will be included in the next design.
Perceptions of COVID-19 related risks by platform-based couriers: An analysis of user comment threads on Reddit
Authors: Meyer Samantha B. , Rotolo Bobbi , Majowicz Shannon , Amoako Joyceline , Crouch Meghan , Hopwood Pamela , Jahangir Yamin T. , MacEachen Ellen
Published: February 2023

BACKGROUND: The COVID-19 pandemic increased demand for app-based platform-based couriers, creating job opportunities for individuals who have lost income because of COVID-19. Through various stages of lockdown, courier workers (e.g., delivering for Uber Eats, Amazon Flex, and Lyft) provide an essential service. At the same time, this form of work poses risks for exposure to the SARS-CoV-2 virus as these workers are highly mobile and in contact with many individuals. OBJECTIVE: To explore how platform-based couriers discuss risks associated with their work during periods of high (first wave, second wave, third wave/rise in concerns regarding variants) and low risk during the COVID-19 pandemic, 2020–2021. METHODS: We provide a narrative analysis of user posts (n = 2,866) on Reddit during periods of interest. RESULTS: Our analysis resulted in three central findings. First, we identified changing patterns in discourse as the pandemic went on. Second, we found that the theme of risk prevailed largely in the first wave, with dialogue dominated by tips and asking for advice about how to manage risk. Third, our findings reveal a growing polarization among users during the latter phases of the study. CONCLUSION: Polarization largely focused on acceptance (or not) of public health measures and the nature of their work as independent contractors and the role/responsibility of courier companies to offer protection. Our study is the first to document risks, from the perspectives of anonymous couriers who may be unwilling to share their honest opinions and thoughts through primary data collection where anonymity is not guaranteed.
The Arab minority of East Jerusalem: An exploratory study of vocational rehabilitation in mental health
Authors: Kheir Samah , Lipskaya-Velkovsky Lena
Published: February 2023

BACKGROUND: The Arab population of East Jerusalem with serious mental illness (SMI) is an ethnic and health status minority that has unique employment issues. Vocational rehabilitation offered to this population is guided by standard regulations that are grounded in knowledge obtained from Western communities on the employment enablers, while negligible research was done to investigate relevance of these enablers for the Arab population. OBJECTIVE: The study aims to examine the previously well-established association between motor, cognitive, and emotional personal factors, occupation features, environmental characteristics, and vocational outcomes of job satisfaction and performance among the Arab population of East Jerusalem with SMI. METHODS: Twenty-three men and women, aged 23–58, from this minority group who had received vocational rehabilitation participated in this cross-sectional study. They completed standard assessments of motor and cognitive skills, self-efficacy, work-environment suitability, and job satisfaction. Employers then rated their level of functioning at work. RESULTS: No correlation was found between the outcome measurements and most of the personal factors and environmental characteristics (p > 0.05), except for an association between job satisfaction, work self-efficacy, and work control. No expected differences were found between vocational rehabilitation programs in the variables of interest (p > 0.05). CONCLUSION: The disparity from well-established patterns of association between enablers and employment outcomes reveals unique characteristics of the investigated population and suggests the impact cultural issues has on vocational rehabilitation. The findings raise an urgent call for an in-depth investigation of the complex phenomenon of employment in this population to support sustainable employment benefits and recovery journey.
Isolation of Keratinolytic Bacteria from Common Ostrich (Struthio Camelus) and their Efficacy towards Feather Degradation of Poultry Waste
Authors: Rafi Uzma , Qureshi Aisha Waheed , Yasmeen Roheela Yasmeen , Noor Sahar , Bokhari Syeda Shazia
Published: February 2023

Keratinolytic microorganisms have the capacity to biosynthesize particular keratinases and determine theirprospective application in poultry waste management. Hence, the objective of this study was to utilize keratinolytic microbes for the degradation of poultry waste. For this purpose, the feathers of common ostrich (Struthio camelus) were collected, scattered along the surrounding dry soil, from a private ostrich farm in Kasur, Pakistan. Bacteria were isolated by using culture enrichment techniques and screened for their proteolytic activity on skim milk agar. The isolates were characterized clonially, morphologically, and biochemically and labeled as SNO1, SNO2, and SNO3, respectively. The effects of varied pH and temperatures were recorded on bacterial growth and feather degradation. It was noticed that the bacterial cell densities and feather degradation were high at 50˚C and pH 8.0, as compared to the rest of the culture conditions. Visual observations were made using a stereomicroscope. The maximum feather degradation in the form of white powdery mass was noticed at fourth (4 th ) week. The protein content of Struthio camelus feathers was determined as 6.5 mg/100 ml after degradation. Taken together, the authors concluded that the isolated strains were capable of feather degradation and can be used in poultry waste management.
Polycystic Ovary Syndrome (PCOS): A Concerning Hormonal Condition and its Bodily Impact on Women
Authors: Saeed Saba , Aslam Taskeen , Javed Eman , Choudhary Maria , Lateef Maria , Bajwa Rimsha Mazhar
Published: February 2023

Polycystic Ovary Syndrome (PCOS) is a prevalent hormonal disorder that have severe health consequences for women. It arises in the early puberty stage and affects a large percentage of the world’s population. While the exact cause is unknown, it’s known to cause hyperandrogenism, insulin resistance, menstrual irregularities, and ovulatory dysfunction, all of which can lead to infertility and endometrial cancer. Long-term cardiometabolic risks and comorbidities are seen in both slim and obese PCOS patients. Given these serious implications, it’scritical to fully comprehend the pathophysiological relationships that underpin PCOS, so that better treatment plans can be developed and the standard of living for women having this condition may improve. This condition is diagnosed using three separate criteria. Rotterdam criterion is mostly utilized for PCOS diagnosis. Different symptoms of PCOS are treated in different ways. It’s imperative to comprehensively treat these patients as soon as possible in order to cope with the emotion burden associated with the disease that is often ignored. PCOScan be managed by early diagnosis and long-term treatment, allowing women to maintain a healthy lifestyle and avoiding long-term complications, including metabolic syndrome and cardiovascular diseases.
Towards Modeling Artificial Consciousness
Authors: Vakulenko Maksym
Published: February 2023

A new synergetic approach to consciousness modeling is proposed, which takes into account recent advancements in neuroscience, information technologies, and philosophy.
FAKTOR - FAKTOR YANG MEMPENGARUHI PROFITABILITAS PADA SEKTOR PERBANKAN YANG TERDAFTAR DI BEI
Authors: Ardelia Rahmadina , Muchtar Susy
Published: February 2023

Profitabilitas bank mampu membantu bank dalam melihat kinerjanya dalam periode tertentu. ROA bank sempat meningkat meskipun terjadi pandemi covid-19. Diketahui peningkatan ini memperlihatkan kinerja bank yang cukup baik. Tujuan dari dilakukan penelitian ini untuk menganalisis faktor-faktor yang mempengaruhi profitabilitas perbankan. Variabel yang digunakan yaitu ukuran bank, efisiensi operasional, likuiditas, CAR, dan GDP dengan variabel dependen profitabilitas meliputi ROA dan NIM. Sampel sebanyak 39 bank yang tercatat di Bursa Efek Indonesia periode 2017-2021 menggunakan teknik analisis regresi data panel. Kebaruan dilakukannya penelitian ini memasukkan variabel NIM. Penelitian memperlihatkan hasil dimana ukuran bank dan GDP berpengaruh positif dan signifikan terhadap ROA dan NIM. Sementara CAR berpengaruh signifikan dan negatif terhadap NIM. Namun, tidak terdapat pengaruh dari CAR dan likuiditas terhadap ROA.

Keywords: CAR, GDP, likuiditas, profitabilitas
The Hermeneutics of Van Eyck’s Ghent Altarpiece
Authors: Miščin Daniel
Published: February 2023

The abundant literature on the Ghent Altarpiece, one of the most important artworks of the Northern Renaissance, completed in 1432 by Van Eyck, often claims that the Annunciation scene on that altarpiece is simply an illustration of the text Lk 1:26–38, followed faithfully by Van Eyck. Although it is beyond doubt that Van Eyck drew inspiration from that text, this paper attempts to establish and explore a different hypothesis, namely that Van Eyck intentionally moved away from Luke’s text of the Annunciation, and for a very good reason, which is related to the composition and the message of the Ghent Altarpiece as a whole. The paper approaches this ‘unconventional’ hypothesis primarily by analyzing two possible approaches to the text of the Annunciation; the idyllic and the kenotic one. In this context, Van Eyck’s way of presenting the Annunciation is observed from the perspective of the theoretical contributions to the hermeneutics of Luke’s text, primarily in the work of Søren Kierkegaard and Joseph Ratzinger, in line with the kenotic (or existential) interpretation.
MODELING THE RELATIONSHIP BETWEEN THE AMOUNT OF CAPITAL INVESTMENT IN TEMPORARY ACCOMMODATION AND CATERING AND THE NUMBER OF TOURISTS
Authors:   Ivan Franko National University of Lviv, Savitska Olha
Published: February 2023

At the present stage in Ukraine the tendencies of development of the sphere of services, in particular tourist activity, hotel and restaurant business, etc. are intensifying. Tourism is one of the most dynamic and promising sectors of the world economy. The development of the tourism industry of Ukraine requires significant investments, attraction of innovative technologies, use of the latest developments and achievements of the world community and the experience of countries with a high level of tourism development. The article analyzes the dynamics of capital investment in temporary accommodation and food and beverage activities, as well as the dynamics of the number of tourists served by tour operators and travel agents. The preconditions and factors that influenced the change in the volume of capital investment and the number of tourists during the analyzed period 2010–2020 were identified. The simulation was performed using correlation-regression analysis by constructing an equation of pairwise linear regression with subsequent estimation of its parameters by the method of least squares. The statistical significance of the equations was verified using the coefficient of determination and Fisher's test. Regression lines have been built, which allow to visually assessing the relationship between the amount of capital investment in temporary accommodation and catering and the number of tourists. The reasons for the high dependence of the number of tourists on the volume of capital investment in catering and the moderate dependence on the volume of capital investment in temporary accommodation are explained. The study of trends in capital investment in tourism, temporary accommodation and catering will identify the strengths and weaknesses of tourism, hotel and restaurant business, as well as problems, threats and barriers to the development of the tourism market.
EVOLUTION OF THE CONCEPTUAL BASIS OF THE INEFFICIENT INSTITUTIONS RESEARCHES
Authors:   Taras Shevchenko National University of Kyiv, Zavazhenko Andrii
Published: February 2023

The article describes the methodological analysis of the evolutionary development of the conceptual foundations of the inefficient institutions' study based on the analysis of the scientific achievements of institutional economic theory representatives within the framework of research programs of traditional and new institutionalism. The difference between the terms inefficient institutions and institutional dysfunctions are shown. It was established that the methodological foundation of the inefficient institutions' analysis was laid by representatives of traditional institutionalism, but the flourishing of research occurred only after the formation of a new analytical apparatus. The author separately described the content of scientific approaches to the analysis of inefficient institutions and noted the creators of these concepts using the example of the lock-in effect, path dependence, qwerty effects and institutional traps. Current thematic areas of research on inefficient institutions are systematized, among which global inefficient institutions, extractive states, problems of transition economies and convergent-divergent development of economic systems are distinguished. It is proven that the dominant scientific problem is the differentiation of the economic development of different countries, the variability of the implementation of institutional changes and the role of inefficient institutions in this process. The author emphasizes that the assessment of the negative impact of institutions within the framework of modern research is only indicative. This theoretical limitation also applies to institutional analysis in general and is one of the scientific problems within the framework of institutionalism, as it is an obstacle to assessing the impact of the institutional environment on economic development, and the effectiveness of implemented or planned socio-economic transformations. Further scientific development requires the identification and specification of causal factors of global institutional imbalances, and insufficient social and economic effectiveness of institutional transformation, without which effective correction of its further strategy and tactics is impossible.
PENGARUH BUDAYA ETIS ORGANISASI DAN INTEGRITAS TERHADAP KUALITAS AUDIT DENGAN SENSITIVITAS ETIKA AUDITOR SEBAGAI VARIABEL MODERASI PADA KANTOR AKUNTAN PUBLIK DI DENPASAR
Authors: Dewi Ni Putu Sintya Utami , Sumadi Ni Komang
Published: February 2023

The purpose of this study is to study and obtain evidence about the culture and organization associated with quality that is moderated by the ethical sensitivity of auditors at the Public Accounting Firm in Denpasar. Location of the study was conducted at the Public Accountant Office in Denpasar. The sampling technique used was purposive sampling, namely the determination of sampling with a specific purpose. Methods of data collection using questionnaires, interviews, observation and document recording. Testing the validity and reliability of the variables shows that the instrument variables are fully valid and reliable. The classic assumption test on the regression model shows that the data is normally distributed, does not contain heteroscedasticity and does not contain any multicollinearity.The results of the regression analysis show that the independent variables influence the variation of the variable preparation of financial statements (dependent). Hypothesis testing using the statistical test of t shows that the organizational ethical culture variable on audit quality shows the significance value of the t test of 0.020 which is smaller than Î± (real level) = 0.05, so it can be concluded that the organizational ethical culture is positive towards audit quality. Integrity variable on audit quality shows the significance value of t test of 0.019 which is smaller than Î± (real level) = 0.05, it can be concluded that the integration is positive for audit quality. The role of the auditor's ethical sensitivity in moderating the relationship of an organization's ethical culture to audit quality is approved by a significance value of 0.003 which concluded that the auditor's ethical sensitivity can strengthen the organizational ethical culture's relationship to audit quality. The role of the auditor's ethical sensitivity in moderating the relationship of integrity to audit quality is considered by a significance value of 0.038 which added to the ethical sensitivity of the auditor can increase the integrity competence of audit quality.
PENGARUH PENGENDALIAN INTERN KAS, FINANCIAL PRESSURE, KESESUAIAN KOMPENSASI, DAN MORALITAS INDIVIDU TERHADAP KECURANGAN (FRAUD) PADA LPD DI KECAMATAN TAMPAKSIRING GIANYAR
Authors: Suprapta Erisianita Lestari , Padnyawati Kadek Dewi
Published: February 2023

Fraud or commonly called fraud is a fraudulent act that is done intentionally to benefit one party (an individual, company or institution) unfairly or violates the law resulting in losses on the other party. This study aims to determine the effect of cash internal control, financial pressure, suitability of compensation, and individual morality for fraud. The population in this study were LPD employees throughout Tampaksiring Gianyar District. The number of respondents used was 63 peoples. The method used in determining the sample using the Slovin formula. Based on the results of this study indicate that financial pressure has a positive and significant effect on fraud, while internal cash control, suitability of compensation, and individual morality do not significantly influence fraud (fraud) in LPDs in Tampaksiring Gianyar District.
PENGARUH AKUNTABILITAS, TRANSPARANSI, PARTISIPASI MASYARAKAT TERHADAP PEMBERDAYAAN MASYARAKAT DALAM PENGELOLAAN DANA DESA PADA DESA SONGAN B KECAMATAN KINTAMANI KABUPATEN BANGLI
Authors: Putri Ade Ayu Anggreni , Sudiana I Wayan , Putra I Putu Deddy Samtika
Published: February 2023

Village funds are the source of income for each village, need to be controlled over their management, it should right on target and can improve people's lives. This study aims to determine the effects of Accountability, Transparency, Community Participation on Community Empowerment in Village Fund Management in Songan B Village, Kintamani District, Bangli Regency. The population in this study were the people of Songan B Village, Kintamani District, Bangli Regency who had voting rights and / or were 17 years old, while 100 people were the object of research (sample). The sampling technique used was purposive sampling technique. The results showed that the variables of transparency and community participation had a positive and significant effect on community empowerment, while the accountability variable had no effect on community empowerment.
PENGARUH PENGENDALIAN INTERNAL DAN MORALITAS INDIVIDU TERHADAP KECURANGAN (FRAUD)
Authors: Kesumawati Luh Era , Pramuki Ni Made Wisni Arie
Published: February 2023

This study aims to obtain evidence of differences in the likelihood of committing fraud between individuals in the event that there are elements of internal control and no elements of internal control, differences in the likelihood of committing fraud between individuals who have a high level of morality and those who have a high level of morality low. Participants in this study were 70 cooperative managers consisting of the chairman, secretary and treasurer in all villages of Batubulan, Gianyar Regency. The research design used was an experimental design with a 2X2 factorial design. To test the hypothesis in this study, the Two Way Analysis of Variance (ANOVA) statistical test was used. The results showed that there was no difference in the likelihood of committing fraud between individuals in the event that there was an element of internal control and no element of internal control. In addition, this study also proves that there are differences in the possibility of committing fraud between individuals who have a high level of morality and those who have a low level of morality.
PENGARUH MORALITAS INDIVIDU, KOMITMEN ORGANISASI DAN WHISTLEBLOWING SYSTEM TERHADAP PENCEGAHAN KECURANGAN (FRAUD) DALAM PENGELOLAAN KEUANGAN DESA
Authors: Evia Lestari Ida Ayu Mega , Ayu Putu Cita
Published: February 2023

Fraud prevention is an effort made to prevent someone from committing fraudulent acts that can cause losses. This study aims to determine the effect of individual morality, organizational commitment and a whistleblowing system on the prevention of fraud in village financial management. This research was conducted in all villages in the District of Mengwi. The sample in this study was 86 village officials. The sampling method used was proportionate stratified random sampling. The data analysis technique used in this research is descriptive statistics, validity test, reliability test, classical assumption test, multiple linear regression, coefficient of determination, F test, and t test. From the results of this study that the variables of individual morality, organizational commitment, whistleblowing system have a positive and significant effect on fraud prevention.
ХАРАКТЕРИСТИКА ПРОЦЕДУР ВІДНОВЛЕННЯ НА ПОСАДІ НЕЗАКОННО ЗВІЛЬНЕНОГО ДЕРЖАВНОГО СЛУЖБОВЦЯ
Authors: Кашпур О. В.
Published: February 2023

Актуальність статті полягає в тому, що повноцінна реалізація процедури оскарження рішення про незаконне звільнення державного службовця від незаконного звільнення є лише частиною захисту наданих даному суб’єкту прав та законних інтересів. Саме по собі оскарження дозволяє лише звернути увагу на факт незаконного припинення державної служби та позначити його «незаконність» офіційним рішенням у формі відповідного юридично значимого документу, зокрема, судового рішення. Але, в даному випадку найбільш бажаним кінцевим результатом має стати поновлення державного службовця на посаді, що, в свою чергу, надасть йому можливість подальшої служби на посадах в публічних органах. Проте, процедури відновлення на посаді складають окрему групу адміністративних процедур, які мають власні особливості здійснення. У статті, спираючись на аналіз наукових поглядів вчених та норм чинного законодавства, проаналізовано порядок відновлення на посаді незаконно звільненого державного службовця. Встановлено наявність двох ключових процедур, які складають зміст та механізм відновлення на посаді. На основі аналізу процедур відновлення на посаді незаконно звільненого державного службовця виділено існуючи недосконалості правового регулювання у даному напрямку. Наголошено, що норми спеціальної нормативної бази не регулюють особливі питання відновлення державного службовця на посаді, зокрема у випадку зайняття його посади іншим державним службовцем або ліквідації органу влади загалом. З’ясовано, що спеціальна нормативно-правова база не містить норм, котрі регулюють порядок виплати компенсацій за незаконне звільнення а також заробітної плати за час вимушеного прогулу. Процедура відновлення державного службовця на посаді загалом не згадується за текстом Закону України «Про державну службу» у зв’язку із чим даний нормативний акт не містить будь-яких гарантій забезпечення прав цієї категорій працівників в контексті відносин, пов’язаних із поновленням їх трудового зв’язку із державним органом.
ANALYSIS OF THE IMPLEMENTATION OF PERFORMANCE ASSESSMENT ON THEMATIC LEARNING IN ELEMENTARY SCHOOLS
Authors: Wafiqni Nafia , Marini Arita , Sari Putri Ilam
Published: February 2023

This research was conducted to obtain an overview of teacher planning, implementation and reporting in the assessment of performance in thematic learning in elementary schools. This reseach uses descriptive qualitative method. The subjects in this strudy were the principal, elementary school coordinator teacher, and teachers grade I – VI. The techniques used in data collection are interviews, observation, and documentation. This study will obtain complete data, namely primary data and secondary data, where primary data is obtained through observations and interviews, while secondary data is obtained through documents, photographs and videos related to performance work. Data were analyzed through steps of data reduction, data presentation, and conclusion concluded. The results of this study show three conclusions. First, planning decides the performance assessment to complete the objectives to be achieved, chooses activities that are suitable for students, determines assessment criteria and compiles a performance rubric. Second, approve the performance assessment, complete the discussion of the availability of tools and materials, provide and submit the rubric of the performance, conduct question and answer and discussion about the rubric, monitor the process of carrying out the performance tasks, conduct research according to the rubric, improve it and improve it. Third, reporting the performance assessment is presented in the form of numbers and descriptions that are delivered to students, fellow teachers, school management teams and participants at PTC (Parent Teacher Conference). Performance appraisal encourages comprehensive, teachers apply performance appraisal in applying the knowledge and attitudes that students relate to performance skills. Carrying out performance tasks is hampered by time, solutions that can be done provide students with understanding material before carrying out performance tasks.
Pelatihan Aplikasi ENFORCE dalam Mempromosikan Independent Learning bagi Siswa Jurusan Manajemen Perkantoran SMKS Budi Dharma Dumai
Authors: Wahyuni Sri , Satriani Estika , Etfita Fauzul , Asnawi Asnawi
Published: February 2023

This service aims to increase the knowledge and capability of SMKS Budi Dharma Dumai students regarding the application of ENFORCE in promoting independent learning. This service method employed training with three stages: first, the pre-activity stage; second, the core activity stage; and third, the evaluation stage. The number of participants in this dedication was nine tenth-grade students majoring in Office Management. The instrument for evaluating this activity used a questionnaire and was analyzed descriptively. The results of this dedication showed that most students favorably responded that ENFORCE was very useful in learning English for office because the material was presented in an exciting and precise manner. From personalization, authenticity, and connectivity, this application is easily accessible, provides original resources, and provides opportunities for self-study. After participating in this training, students stated that they would use this application as an additional learning reference at school and home.
PkM: Workshop Implementasi Kurikulum Merdeka Belajar Bagi Guru IPS SMP di Kota Kediri
Authors: Anas M. , Muchson Mochamad , Sugiono Sugiono , Forijati Rr. , Subagyo Subagyo , Yuliani Tri
Published: February 2023

This community service aims to provide adequate understanding and skills for Social Science (IPS) teachers in junior high schools (SMP) in the city of Kediri related to the implementation of the Merdeka Belajar Curriculum (CMB) and the output of this activity is in the form of Differentiated Teaching Modules for IPS subjects in SMP. The community service method is in the form of a workshop including test activities (pre-test and post-test, CMB literacy tutorials and assignments (performance). The data analysis technique uses a paired sample test with the help of the SPSS V.23 application. The community service results show that 1) this service activity is effective because it has been able to improve the pedagogical competence of IPS teachers of SMP in the City of Kediri, 2) there are significant differences in the pedagogical competence of IPS teachers of SMP in the City of Kediri between before and after participating in the community service activities of CMB implementation workshops, and 3) resulted differentiated teaching modules of IPS subjects in SMP.
Peningkatan Keterampilan Guru dalam Pembuatan Media Pembelajaran Berbasis Android Bermuatan Soal AKM
Authors: Effendi Moh Mahfud , Cahyono Hendarto , Ummah Siti Khoiruli , Hasanah Rusi Ulfa
Published: February 2023

This community service activity aims to describe improving teacher skills in making Android-based learning media containing AKM questions. The method of the service program was carried out with pre-activity procedures, implementation of activities which included training and mentoring, and evaluation. The instrument for evaluating this activity used a questionnaire and was analyzed descriptively. This service's results showed that teachers could create Android-based learning media. The questionnaire results distributed to teachers as training participants were the Kodular application used to develop media that was easy to use and attractive in terms of appearance. The results of the questionnaire given to students after the trial were that students were interested in learning to use Android-based media because it was practical and easy to access at any time. In addition, through Android-based media, it was easy for students to answer AKM-type questions, so as many as 84% of students passed the AKM.
Rancang Bangun Sistem Kendali Kipas Angin dengan Sensor Suhu dan Sensor Ultrasonik Berbasis Arduino Uno
Authors: Sudrajat Rakhmat , Rofifah Fahimatu
Published: February 2023

Kipas angin merupakan perangkat elektronik konvensional yang sering dipergunakan sebagai pengatur sirkulasi udara pada saat cuaca panas. Pada saat ini pengendalian ON/OFF masih dikendalikan secara manual dengan saklar terasa kurang efisien. Oleh karena itu diperlukan suatu sistem yang dapat mengendalikan ON/OFF tersebut secara otomatis dengan menyesuaikan posisi objek serta suhu udara didalam ruangan sehingga menghemat penggunaan energi listrik. Dengan memanfaatkan sensor ultrasonik HC-SR04 untuk mendekteksi objek dalam ruangan, sensor DHT11 yang berfungsi mengukur suhu udara didalam ruangan, modul Relay untuk mengendalikan ON/OFF kipas angin yang sesuai dengan posisi objek. Saat objek dalam ruangan terdeteksi, maka sensor suhu akan mengukur suhu untuk menentukan apakah kipas angin akan menyala atau tidak.
Does Marx hold that capitalism is unjust? A Reply to Zhongqiao Duan
Authors: Wood Allen
Published: February 2023

This paper is a reply to Zhongqiao Duan, who challenges my reading of Karl Marx on the question whether capitalism can be criticized on grounds of justice. Marx is naturally read as claiming that capitalism is unjust to wage labourers, but perhaps surprisingly, Marx never makes such claims, but on the contrary denies that capitalism is unjust, and even scolds working class advocates for making the charge of injustice against capitalism. Although Marx charges capitalism with exploiting workers, he does not consider this unjust because capitalist exploitation only corresponds to the prevailing mode of production, and Marx regards standards of justice as consisting in correspondence to the prevailing productive mode. Duan raises several objections to the account just summarised and I reply to them.
Democratic Trust and Injustice
Authors: Ivison Duncan
Published: February 2023

Trust is a crucial condition for the legitimacy and effectiveness of democratic institutions in conditions of deep diversity and enduring injustices. Liberal democratic societies require forms of engagement and deliberation that require trustful relations between citizens: trust is a necessary condition for securing and sustaining just institutions and practices. Establishing trust is hard when there is a lingering suspicion that the institutions citizens are subject to are illegitimate or undermine their ability to participate and deliberate on equal terms. The promise of participation, the appeal to deliberation and inclusion, in other words, is experienced as a form of bad faith. In this paper, I offer four conditions required for democratic trust and discuss them in relation to a series of examples of both democratic mistrust and attempts at rebuilding trust.
Food protein-induced enterocolitis syndrome: Healthcare utilization and referral patterns among a pediatric cohort
Authors: Pier Jennifer , Bingemann Theresa , Badwal Jasdeep , Rosloff Daniel , Pasha Muhammad , Wang Hongyue , Lomas Jeanne M. , Järvinen Kirsi M.
Published: February 2023

Background

Food protein–induced enterocolitis syndrome (FPIES) is a non-IgE mediated food allergy characterized by delayed, repetitive vomiting. FPIES is improving in recognition; however, there remains a lag in diagnosis. This study aimed to further explore this lag, as well as referral patterns and healthcare utilization, to help determine areas for earlier recognition.

Methods

A retrospective chart review of pediatric FPIES patients at two hospital systems in New York was completed. Charts were reviewed for FPIES episodes and healthcare visits prior to diagnosis, and reason/source of referral to an allergist. A cohort of patients with IgE-mediated food allergy was reviewed for comparison of demographics and the time to the diagnosis.

Results

In total, 110 patients with FPIES were identified. The median time to diagnosis was 3 months, vs. 2 months in IgE-mediated food allergy (p < 0.05). Most referrals were from the pediatrician (68%) or gastroenterology (28%), none were from the ED. The most common reason for referral was concern of IgE-mediated allergy (51%), followed by FPIES (35%). There was a statistically significant difference in race/ethnicity between the FPIES cohort and IgE-mediated food allergy group (p < 0.0001), with a greater proportion of Caucasian patients in FPIES vs. IgE-mediated food allergy cohort.

Conclusion

This study demonstrates a lag in the diagnosis of FPIES and a lack of recognition outside of the allergy community, as only one-third of patients were considered to have FPIES prior to an allergy evaluation.
Enhancing plant growth promoting rhizobacterial activities through consortium exposure: A review
Authors: Singh Anamika , Yadav Virendra Kumar , Chundawat Rajendra Singh , Soltane Raya , Awwad Nasser S. , Ibrahium Hala A. , Yadav Krishna Kumar , Vicas Simona Ioana
Published: February 2023

Plant Growth Promoting Rhizobacteria (PGPR) has gained immense importance in the last decade due to its in-depth study and the role of the rhizosphere as an ecological unit in the biosphere. A putative PGPR is considered PGPR only when it may have a positive impact on the plant after inoculation. From the various pieces of literature, it has been found that these bacteria improve the growth of plants and their products through their plant growth-promoting activities. A microbial consortium has a positive effect on plant growth-promoting (PGP) activities evident by the literature. In the natural ecosystem, rhizobacteria interact synergistically and antagonistically with each other in the form of a consortium, but in a natural consortium, there are various oscillating environmental conditions that affect the potential mechanism of the consortium. For the sustainable development of our ecological environment, it is our utmost necessity to maintain the stability of the rhizobacterial consortium in fluctuating environmental conditions. In the last decade, various studies have been conducted to design synthetic rhizobacterial consortium that helps to integrate cross-feeding over microbial strains and reveal their social interactions. In this review, the authors have emphasized covering all the studies on designing synthetic rhizobacterial consortiums, their strategies, mechanism, and their application in the field of environmental ecology and biotechnology.
Comparative analysis of the cardiomyocyte differentiation potential of induced pluripotent stem cells reprogrammed from human atrial or ventricular fibroblasts
Authors: Wang Lu , Nguyen Thanh , Rosa-Garrido Manuel , Zhou Yang , Cleveland David C. , Zhang Jianyi
Published: February 2023

Background: We had shown that cardiomyocytes (CMs) were more efficiently differentiated from human induced pluripotent stem cells (hiPSCs) when the hiPSCs were reprogrammed from cardiac fibroblasts rather than dermal fibroblasts or blood mononuclear cells. Here, we continued to investigate the relationship between somatic-cell lineage and hiPSC-CM production by comparing the yield and functional properties of CMs differentiated from iPSCs reprogrammed from human atrial or ventricular cardiac fibroblasts (AiPSC or ViPSC, respectively).

Methods: Atrial and ventricular heart tissues were obtained from the same patient, reprogrammed into AiPSCs or ViPSCs, and then differentiated into CMs (AiPSC-CMs or ViPSC-CMs, respectively) via established protocols.

Results: The time-course of expression for pluripotency genes (OCT4, NANOG, and SOX2), the early mesodermal marker Brachyury, the cardiac mesodermal markers MESP1 and Gata4, and the cardiovascular progenitor-cell transcription factor NKX2.5 were broadly similar in AiPSC-CMs and ViPSC-CMs during the differentiation protocol. Flow-cytometry analyses of cardiac troponin T expression also indicated that purity of the two differentiated hiPSC-CM populations (AiPSC-CMs: 88.23% ± 4.69%, ViPSC-CMs: 90.25% ± 4.99%) was equivalent. While the field-potential durations were significantly longer in ViPSC-CMs than in AiPSC-CMs, measurements of action potential duration, beat period, spike amplitude, conduction velocity, and peak calcium-transient amplitude did not differ significantly between the two hiPSC-CM populations. Yet, our cardiac-origin iPSC-CM showed higher ADP and conduction velocity than previously reported iPSC-CM derived from non-cardiac tissues. Transcriptomic data comparing iPSC and iPSC-CMs showed similar gene expression profiles between AiPSC-CMs and ViPSC-CMs with significant differences when compared to iPSC-CM derived from other tissues. This analysis also pointed to several genes involved in electrophysiology processes responsible for the physiological differences observed between cardiac and non-cardiac-derived cardiomyocytes.

Conclusion:AiPSC and ViPSC were differentiated into CMs with equal efficiency. Detected differences in electrophysiological properties, calcium handling activity, and transcription profiles between cardiac and non-cardiac derived cardiomyocytes demonstrated that 1) tissue of origin matters to generate a better-featured iPSC-CMs, 2) the sublocation within the cardiac tissue has marginal effects on the differentiation process.
Selective depletion of regulatory T cells enhances the immunogenicity of a recombinant-based vaccine against Sporothrix spp
Authors: Batista-Duharte Alexander , Téllez-Martínez Damiana , Portuondo Deivys Leandro , Carlos Iracilda Zeppone
Published: February 2023

Introduction

Regulatory T cells (Tregs) have been shown to limit the protective immune response against pathogenic species of the fungus Sporothrix spp, the causal agent of sporotrichosis. However, the specific function of Tregs during vaccination against these fungi is known.

Methods

We evaluated the effect of Tregs depletion on the immunogenicity of an experimental recombinant anti-Sporothrix vaccine, using the DEREG mice. In this model, only Foxp3(+) Tregs express eGFP and diphtheria toxin (DT) receptors, and transient Tregs depletion is achieved by DT administration.

Results

Tregs depletion enhanced the frequency of specific IFNγ+ T cells (Th1 lymphocytes) and cytokine production after either the first or second vaccine dose. However, depletion of Tregs during the second dose caused greater stimulation of specific Th1 lymphocytes than depletion during the first dose. Similarly, the highest production of IgG, IgG1, and IgG2a anti rSsEno antibody was detected after Tregs depletion during boost immunization compared to the other immunized groups. Importantly, vaccine immunogenicity improvement after Tregs depletion also had an impact on the more efficient reduction of fungal load in the skin and liver after the challenge with S. brasiliensis in an experimental infection model. Interestingly, the reduction in fungal load was greatest in the Tregs depleted group during boosting.

Discussion

Our results illustrate that Tregs restrict vaccine-induced immune response and their transient depletion could enhance anti-Sporothrix vaccine immunogenicity. Further studies are required to elucidate whether Tregs depletion may be a way to improve the efficacy of vaccination against Sporothrix spp.
Profiling Blautia at high taxonomic resolution reveals correlations with cognitive dysfunction in Chinese children with Down syndrome
Authors: Hou Xueyu , Wu Na , Ren Shimeng , Wang Xinjuan , Mu Qing , Zhang Yang , Wang Shan , Yu Weidong , Guo Jingzhu
Published: February 2023

Introduction

Down syndrome (DS), the presence of a supernumerary chromosome 21, is associated with cognitive dysfunction caused by early neurodegenerative processes. Alterations in the gut microbiota were observed in Chinese children with DS, and the genus Blautia was associated with cognitive function in these children. Therefore, it is crucial to understand the detailed composition of this group at the species level and to explore the effect of specific species on cognitive function.

Methods

In this study, Blautia-specific amplicon sequencing was conducted to identify the specific Blautia species in 15 children with DS and 15 matched healthy children.

Results

The taxonomic analyses suggested that the Blautia taxa were clustered by disease status. The diversity of Blautia at the species level differed between DS patients and healthy controls, with the abundances of Blautia massiliensis and Blautia argi decreasing in DS children, while Blautia faecis was increased. Acetic acid, one of the metabolites of Blautia, was significantly reduced in the DS group. Of particular interest, Kyoto Encyclopaedia of Genes and Genomes analysis revealed decreased modules related to starch and sucrose metabolism and glycolysis. In addition, B. argi was positively related to DS cognitive scores, and B. faecis was negatively related to cognitive function, implying its role on the DS cognitive impairments.

Discussion

Our study has important implications for understanding the important effects of specific species of Blautia on cognitive function and thus possibly provides a new strategy for future studies of cognitive improvement in individuals with DS.
From stereotype to reality: A pilot study on the use of science, technology, engineering, and mathematics and STEAM in design education in Taiwan
Authors: Sun Yikang , Ni Chien-Chih , Lin Rungtai
Published: February 2023

Currently, STEAM interventions in design education are a relatively new phenomenon. A design education system derives from three major ideas from the Bauhaus: (1) art and technology: a new unity; (2) human-centered design; and (3) interdisciplinarity, which is the essence and connotation of STEAM. In the transition from STEM to STEAM, the concept and mindset of art connect the four disciplines within STEM, elevating these tools and methods into a strategy. It is urgently necessary for design educators to restructure their curriculum using STEAM models and thought. However, there is no evidence that the integration of these disciplines will improve design education for the public. Consequently, this study examines the perception of educators and the public regarding the use of STEAM in design education. Using expert interviews, six design schools were selected as samples, and questionnaires were used to collect and analyze the views of different groups of people. According to the results, the expert group scored fairly high; and other groups will form stereotypes based on the characteristics of the school, resulting in a polarized assessment of STEAM. All groups displayed cognitive differences in many aspects. It is evident from this study that the STEAM model should be incorporated into design education; however, it is necessary to determine objectively the relationship between the five attributes and their relative importance within different design fields. Under the premise of complying with policies, regulations, and the actual situation of the school, the design of the curriculum planning needs to be adjusted and supplemented in a timely manner according to the STEAM model. Specifically, it cannot be arranged arbitrarily for STEAM, but it should also let students understand what STEAM is about so that they can understand why these courses exist. Furthermore, researchers should examine the effectiveness of these courses over time by conducting a phased retrospective.