bluuebunny/crossref_metadata_2025 huggingface dataset:
Synthesis, Characterization, and Reactivity of a Synthetic End-on Cobalt (II) Alkyl Persulfide Complex as a Model Platform for Thiolate Persulfidation
Authors: Li Keyan , Zakharov Lev , Pluth Michael
Published: May 2024

Persulfides (RSS–) are ubiquitous source of sulfides (S2–) in biology, and interactions between RSS– and bioinorganic metal centers play critical roles in biological hydrogen sulfide (H2S) biogenesis, signaling, and catabolism. Here we report the use of contact-ion stabilized [Na(15-crown-5)][tBuSS] (1) as a simple synthon to access rare metal alkyl persulfide complexes and to investigate the reactivity of RSS– with transition metal centers to provide insights into metal thiolate persulfidation includ-ing the fundamental difference between alkyl persulfides and alkyl thiolates. Reaction of 1 with [CoII(TPA)(OTf)]+ afforded the η1-alkyl persulfide complex [CoII(TPA)(SStBu)]+ (2), which was characterized by X-ray crystallography, UV-vis spectros-copy, and Raman spectroscopy. RSS– coordination to the Lewis acidic Co2+ center provided additional stability to the S–S bond as evidenced by a significant increase in the Raman stretching frequency for 2 (vS–S = 522 cm–1, ΔvS–S = 66 cm–1). The effect of persulfidation on metal center redox potentials was further elucidated using cyclic voltammetry, in which the Co2+ → Co3+ oxidation potential of 2 (Ep,a = +89 mV vs SCE) is lowered by nearly 700 mV when compared to the corresponding thiolate complex [CoII(TPA)(StBu)]+ (3) (Ep,a = +818 mV vs SCE), despite persulfidation being an oxidative post-translational modifica-tion. Reactivity of 2 toward reducing agents including PPh3, BH4–, and biologically relevant thiol reductant DTT led to differ-ent S2– output pathways including formation of a dinuclear 2Co-2SH complex [CoII2(TPA)2(µ2-SH)2]2+(4).
Incremento de la productividad en una empresa ganadera láctea de la región Arequipa, Perú, mediante la aplicación de lean manufacturing
Authors: Puertas Aragon Carlos Nicolas , Lozada Rivera Daniel Efraín
Published: May 2024

Se investiga el impacto de la metodología lean manufacturing en el proceso de ordeño de una empresa ganadera en Arequipa. Primero, se reconocen el contexto, la situación actual de la industria y la problemática. Seguidamente, se comenta la metodología utilizada. Luego, se muestran los resultados: pretest, aplicación de 5S, kanban y housekeeping, y postest. Finalmente, se discuten los hallazgos y se presentan las conclusiones. La aplicación de la metodología demuestra ser efectiva en la empresa, pues se logra un incremento de 12,66 % en la productividad. Asimismo, la organización, estandarización de procesos y eliminación de elementos que no agregan valor permiten una reducción de las demoras en 25 %. Además, las mermas por volumen de leche producida disminuyen en 16,28 % por la limpieza e implementación de controles de salubridad. Al reducir el tiempo del proceso, el consumo de energía y los insumos utilizados, los costos directos sobre los ingresos descienden en 9,34 %.
Comparación de pronósticos con demanda intermitente en una empresa de empaques de plástico
Authors: Sánchez García Alex Víctor , Taquía Gutiérrez José Antonio
Published: May 2024

En el presente artículo se comparan tres métodos de pronósticos de demanda, aplicados en una empresa peruana productora de envases de plástico para el sector cosmético con demanda intermitente. Los métodos comparados fueron Croston, Croston TSB y suavizamiento exponencial. Las métricas de error que se usaron y compararon para realizar los pronósticos fueron el error medio absoluto, el error porcentual medio y el error cuadrático medio. Se observó que el modelo de Croston TSB obtuvo un mejor rendimiento que los otros dos, con un error menor a 20 % contra la venta real.
Campo-cidade, circuito inferior da economia urbana e a Feira do Produtor de Ceilândia como patrimônio-territorial do DF
Authors: Silva Junior Arthur Lino , Boscariol Renan Amabile
Published: May 2024

As feiras livres se desenvolvem geralmente em áreas periféricas das cidades latino-americanas, resultando da resistência da pequena produção agrícola frente à urbanização e o rural neoliberal que marcam a atual fase da colonialidade no continente latino-americano. Nestas áreas, pobreza urbana e pobreza rural formam nexos territoriais que possibilitam a sobrevivência destas populações e de sua cultura, por dentro do capitalismo periférico. O artigo tem como objetivo analisar o fenômeno das feiras livres a partir do caso singular da “Feira do Produtor e Atacadista de Ceilândia”, na cidade de Brasília-DF. Metodologicamente, utilizamos o conceito de patrimônio-territorial e a teoria dos circuitos da economia urbana para revisar os dados empíricos, levantados por meio de entrevistas semiestruturadas e observação direta. Identificamos que a referida feira constitui ponto de articulação de processos de resistência e reafirmação da cultura popular, propiciando trabalho e consumo para parte da população marginalizada na periferia da capital do Brasil.
De tempos e ritmos, homenagem a Carlos Augusto Figueiredo Monteiro - geógrafo brasileiro
Authors: Souza Maria Adélia Aparecida de , Costa Everaldo Batista da
Published: May 2024

É com muita alegria que a PatryTer homenageia o geógrafo brasileiro Carlos Augusto de Figueiredo Monteiro (foto da capa), neste volume 5, nº 9 da Revista, que lhe é dedicado. Adentrar seu quinto ano de existência homenageando este erudito acadêmico, que contribuiu com o pensamento social e a a disciplina geográfica, ao largo do século XX e primeiras décadas do XXI, é uma grande honra para este periódico.
Revistas científicas en el mundo de la globalización neoliberal
Authors: Costa Everaldo Batista da , Moncada José Omar , Zomighani Jr James Humberto , Lima Luana Nunes M
Published: May 2024

Esto editorial del vol. 5, núm. 9 de PatryTer – Revista Latinoamericana y Caribeña de Geografía y Humanidades cumple el objetivo de problematizar el juego que involucra la supervivencia de las revistas científicas, en el mundo donde el conocimiento se califica, sobre todo, por parámetros formales, monetarios y cada vez más rígidos. El panorama sintetizado aquí servirá de marco para recordar la filosofía de PatryTer. Además, vamos a justificar el homenaje que este número hace al geógrafo brasileño Carlos Augusto Figueiredo Monteiro, de la Universidad de Sao Paulo.
O Demônio São os Outros: a discriminação ao Candomblé como manifestação do racismo
Authors: Pazini Santana CleiLton , Pereira Reid dos Santos André Filipe
Published: May 2024

Considerando a importância da herança africana para a cultura brasileira, este estudo pretende analisar as origens e formas de manifestação de racismo religioso que atinge principalmente religiões de matriz africana. Apresenta as bases históricas que sustentam ideias negativas comumente associadas a essa religião e, então, analisa como essa forma de racismo se manifesta no panorama atual. Observa-se que, embora a Constituição de 1988 preveja ampla liberdade de crença e culto, ainda existem fortes tabus sociais em torno das religiões afro-brasileiras, que se traduzem em violência cultural e também direta. Isso permite concluir que, apesar de ser oficialmente um país laico, a herança de ideias equivocadas herdadas do período escravocrata permanece relegando às religiões de origem africana um papel subalterno na ordem social.
A discriminação contra religiões afro-brasileiras: um debate entre intolerância e racismo religioso no Estado brasileiro
Authors: Fernandes Nathalia Vince Esgalha
Published: May 2024

A luta das religiões afro-brasileiras contra a intolerância religiosa é histórica no Brasil. As agressões físicas, verbais e os atentados ao espaço físico dos templos, a omissão do poder público e a falta de políticas públicas, são algumas das ações de intolerância e discriminação que os praticantes enfrentam desde o período escravocrata até os dias de hoje. A discriminação direcionada contra esse grupo têm a ver com a formação da estrutura estatal sob a modernidade, visto que, para o colonizador, evangelizar as populações submetidas (indígenas e africanos escravizados) era parte fundamental da empreitada colonial. Esse trabalho pretende, portanto, revisitar o artigo de na primeira edição da Revista Calundu explicando a relação entre o racismo presente na formação latino-americana e o fenômeno da discriminação direta e indireta contra as religiões afro-brasileiras.
Dois Amigos Que Tenho
Authors: Dantés Guerra Gabriela Thaisa
Published: May 2024

O texto traz uma reflexão sobre a vivência da autora na Umbanda e como tal vivência a trouxe aprendizados que a mesma leva para a vida, assim como a apresentção de entidades como Pretos-velhos, caboclos, Exus, Eres, dentre outros. A autora traça ainda uma explicação sobre os Caboclos de Pena e os Caboclos Boiadeiros.
O Brasil que Veste Afrodiáspora: a performance cotidiana de mulheres negras no século XIX
Authors: Rossotti Beatrice
Published: May 2024

O presente artigo tem como intuito trazer alguns apontamentos que temos desenvolvido ao analisarmos fotografias de mulheres negras da segunda metade do século XIX, produzidas nas regiões da Bahia e Rio de Janeiro, e utilizá-las como fontes históricas para analisarmos como os modos de vestir dessas mulheres eram registrados nas imagens. A nossa hipótese é de que as roupas e joias presentes nas fotografias partiam da construção cotidiana de uma performance, que era desenvolvida pelas mulheres negras nas práticas socioeconômicas do seu dia a dia. Sendo assim, para este escrito buscamos apresentar como a ideia do “vestir-se” cotidiano integrava uma performance que fazia das mulheres negras agentes que intervinham no modo como seriam registradas e consumidas, por meio das fotos que circulavam.
Trajes Afro-Brasileiros, Roupagens de uma Memória: apresentação
Authors: Nogueira Guilherme Dantas
Published: May 2024

Apresentação do dossiê Trajes Afro-Brasileiros: os transbordamentos estéticos do vestir para além dos limites de terreiro, elaborado em parceria pelo Grupo Fayola Odara e o Grupo Calundu.
Exu diaspórico: um conceito decolonial forjado para compreender o princípio exúlico de comunicação e a pedagogia das encruzilhadas
Authors: Araújo Alex Pereira de
Published: May 2024

Este trabalho trata do conceito Exu Diaspórico, o qual foi forjado para lidar com as pesquisas empíricas situadas dentro do quadro teórico da vaga decolonial. Sua concepção está ligada às tradições iorubanas diaspóricas nessa parte do Atlântico Sul onde emergiram outros sistemas resultantes, quer seja de fragmentos e vestígios de narrativas em gestos de memória e resistência, quer seja da tradução realizada pelo outro, muitas vezes, por meio de um processo de carnavalização cultural, que, por sua vez, se deu pela convivência com os bantu, com os povos autóctones e com o colonizador europeu. Este conceito se articula com o conceito de língua-linguagem como encruzilhada apresentado por Araújo (2021a), mas pode ser tomado, ainda, de forma independente. Portanto, trata-se de uma discussão conceitual que visa contribuir com as reflexões e pesquisas decoloniais. O conceito também está a cargo de noções como negritude e Baianidade. Contudo, ele aparece para reunir todas as representações de Exu que resultaram da diáspora negra em meio a um processo de carnavalização das tradições iorubanas em contato com outras culturas e cosmologias.
Kant entre Franceses, Ingleses e Alemães
Authors: Martins Ferreira Gabriel
Published: May 2024

Dando continuidade a tarefa proposta na primeira parte, o presente artigo pretende apresentar um diálogo entre Kant e Rousseau no que concerne a relação entre ética e antropologia. Nesta segunda parte, o presente artigo pretende explorar a leitura crítica e original que Kant faz da teoria antropológico-perfectibilista de Rousseau. A obra de Rousseau – ou mais precisamente, sua proposta de uma teoria do ser humano – é decisiva para a gênese da antropologia kantiana por representar um ponto de viragem, segundo nossa hipótese interpretativa, nas considerações de Kant acerca não somente da moral, mas fundamentalmente da história e da antropologia.
Heidegger and Foucault
Authors: Miranda de Sousa Clara Maria , Silva de Souza Ribeiro Marcelo
Published: May 2024

Here we discuss the approximations and distances between the contributions of Heidegger’s and Foucault’s thought. We are interested in knowing about the ideas of self-care articulated by Martin Heidegger and of care of the self, according to Michel Foucault, analyzing the convergences and divergences. Contrastive systematization was used in order to highlight the encounters and disagreements between the thinkers. There are similarities regarding the importance given to the issue of caring as something that constitutes the human being, but the distances are given by the way in which the meanings of care are conceived. The approximations and distances regarding self-care and care of the self thought by Heidegger and MichelFoucault make us reflect that each thinker was crossed by singularities, historical, social and cultural processes, unfolding in specific understandings around care.
Bernard Mandeville: Wealth beyond Vice and Virtue
Authors: Hurtado Jimena
Published: May 2024

Bernard Mandeville denounced the moral philosophy of his times, its theoretical and practical dimensions, as elitist and contrary to human nature. The explanations and recommendations derived from this moral philosophy, according to Mandeville, was inadequate to understand and govern commercial society. Mandeville scrutinized existing explanations about human nature, confronted them with what he presented as facts and unraveled their contradictions. This leads to Mandeville’s challenge: accepting things as they are or assuming the responsibility of transformation. This is the challenge I aim at exploring in this paper. We can continue to live in a highly unequal society based upon pride and shame or we can create incentives that will lead to a different calculation of passions in line with a Utilitarian criterion.
Adoption of the Supplemental Food for School Children Program at Kulon Progo City
Authors: Hartika Andi Yuniarsy , Ulumiyah Safira Ainun
Published: May 2024

One of the national programs is providing Supplementary Food for School Children, which was launched to accelerate the achievement of national development goals. This complete food-based program was the first to be carried out in Kulon Progo Regency; in the previous year, this supplementary food program was provided in the form of snacks. This research aims to explore the adoption of the Supplementary Food for School Children program in Kulon Progo Regency. This research used a qualitative design with a case study approach. The selection of informants used a purposive sampling technique. Data collection is done by in-depth interview method and focus group discussion. The validity of the data is done by using source triangulation, member checking, and peer debriefing. This aspect of adoption consists of the program implementer's intention to adopt a program, how the activity implementer tries to implement a program and implements the innovations needed for program development. This is demonstrated by their being able to prepare a team to implement the Supplementary Food for School Children program in schools consisting of cooks and administrative staff, prepare the facilities and infrastructure for implementing the program, and carry out initial anthropometric measurements of school children. Schools receiving the Supplementary Food for School Children program show that they are ready and able to adopt this new program in their respective school settings
Health Care System Application (Good Care) Android-Based at Primary Health Care (Case Study at Clinic of Wijaya Kusuma)
Authors: Prasastin Oliva , Napida Anggi , Fanny Nabilatul
Published: May 2024

The development of information systems is currently experiencing very rapid development which we now recognize as the era of digitalization, one of which is in the field of health services. Primary healthcare is a type of medical health service that provides health services to individuals at the first level health service. The problem that most often arises is related to the registration system which is still done manually by recording in the registration book, thereby allowing the risk of errors occurring and the process of searching for visit data taking a long time. This research aims to improve better service for visits so it is necessary a good, systematic and integrated data handling and processing in a developing service system, even at the level of independent health service practice. This research method uses Field Observation, Library Research, Interviews, Study Research Literature (Research Literature Study), System Design, System Implementation and Testing. Application system from syntax errors and functionally produces functions as expected. The health service system application (Good Care) has been tested and can be used so that it can increase the effectiveness and efficiency of health services at the independent doctor's practice at Clinic of Wijaya Kusuma.
Dynamic response analysis of linear motion stage with track roller guides
Authors: Samuel Mateta , Godffrey Tigere
Published: May 2024

This paper aims at characterizing the role of preload, friction and mass on the dynamic response of the linear motion stage used in the laser marking machine for black granite. A single-axis linear motion stage model was realized in Creo Parametric® CAE software. The mechanism design option was used to create a virtual mechanism with simulation entities for stiffness, friction, mass, damping, and motors. The experimental design was accomplished using Minitab® software to create the Taguchi orthogonal array. The simulation experiments with different values of preload, friction, and mass were conducted. The results show that increasing the linear bearing preload reduced the settling time. Increased elastic deformation increased bearing rigidity, which ultimately helped reduce vibrations and hence settling time. Furthermore, lower levels of friction reduced sticking and slipping, which led to reduced vibration levels and therefore a lower settling time.
The supply and demand for rehabilitation health workforce in Saudi Arabia
Authors: Wasfi Reham M. , Alenezi Faisal S. , Alzubaidi Lamya M. , Hassanein Muna
Published: May 2024

Background: Adequate supply of rehabilitation health workforce is a prerequisite for enhancing access to rehabilitation care. However, there is a lack of comprehensive data regarding the supply of rehabilitation health workers in Saudi Arabia. Aims: To determine the need for, and supply of, rehabilitation workforce, and investigate the relationship between rehabilitation workforce supply and rehabilitation needs in Saudi Arabia. Methodology: This cross-sectional study measured the ratio of physiotherapists and occupational therapists per 10000 population. Data were obtained from the Ministry of Health, family health survey and census data of the General Authority for Statistics and published literature. To assess the need for rehabilitation services, we computed a composite disability index based on 3 variables: count of individuals with physical disabilities, those with chronic diseases, and those aged > 65 years. Determinants of the supply potential were population size, rural population percentage, and physician supply. Data were analysed using descriptive statistics and simple linear regression. Results: The ratios of physiotherapists and occupational therapists working at the Ministry of Health facilities were 0.69 and 0.03 per 10 000 population, respectively. Overall rehabilitation health workforce ratio was 0.73 per 10 000. Supply varied across regions, from 0.4 for Riyadh to 2.5 for Al Jouf. Nine regions exceeded the overall ratio. Rehabilitation need index ranged from 0.144 in Najran to 0.212 in Aseer. No significant associations were found between rehabilitation workforce supply on one hand, and need and other potential determinants on the other hand. Conclusion: The rehabilitation workforce supply in Saudi Arabia surpassed the regional and global averages, but was lower than the average for high-income countries. Workforce distribution varied by region across the country and was not related to need. It is important to consider the need for rehabilitation services and context-specific factors when determining the optimal size and distribution of the rehabilitation health workforce in Saudi Arabia.
Retrospective analysis of an outbreak of scarlet fever in United Arab Emirates
Authors: Sobh Eman Khalifa , Kumarasamy Thiyagaraj A. , Sobh Zahraa Khalifa
Published: May 2024

Background: Scarlet fever is an infectious disease caused by Streptococcus pyogenes. However, there is limited data regarding the disease in the Arab World, including the United Arab Emirates. Objective: To analyse a scarlet fever outbreak in United Arab Emirates. Methods: This retrospective cross-sectional study included scarlet fever cases diagnosed at the Kanad Hospital, Al Ain, United Arab Emirates in 2022 and 2023. Data were retrieved from the hospital records and analysed using SPSS version 23.0. Chi-Square, Mann-Whitney, and Monte Carlo tests were applied. Results: Two hundred and twenty-two cases (13.5% in 2022 and 86.5% in 2023) were confirmed (P<0.001). Majority (67.1%) of the patients were aged 3–6 years, with a mean age of 4.56 ± 1.99 years. Rash, fever and sore throat were observed in 100%, 99.1%, and 82.0% of cases, respectively. The majority (85.1%) were managed as outpatients and 77.0% responded to oral penicillin. Patients' age was not significantly associated with nonresponse to penicillin and in-hospital admission. The outbreak had winter and summer peaks, with the highest incidence occurring during January and February 2023. Conclusion: This study serves as a valuable reference for other studies, which should include antimicrobial susceptibility testing and the prevailing genetic variance of Streptococcus pyogenes.
Efek Steroid Terhadap Kadar Troponin I dan CRP Pada Pasien Bedah Jantung Koroner di RSUD Arifin Achmad Provinsi Riau
Authors: Muharrami Vera
Published: May 2024

Steroids can diminish inflammation and forestall cardiac impairment in cardiac surgery cases, encompassing coronary heart surgery; however, this approach remains a topic of ongoing discussion. The present study investigated the ramifications of administering steroids in coronary heart surgery patients, focusing on the variations in CRP and Troponin I level at Arifin Achmad General Hospital in Riau Province. Employing a cross-sectional design, the study retrospectively reviewed medical records of individuals who had undergone coronary heart surgery between January 2018 and September 2020 at Arifin Achmad Hospital in Riau Province. Comparisons between Troponin I and C-Reactive Protein (CRP) levels were drawn contingent on the specific administered steroid (methylprednisolone or dexamethasone). The study further examined secondary outcomes, encompassing myocardial contractility, duration of ventilator employment, and Intensive Care Unit (ICU) length of stay, distinguishing patterns based on the steroid type. Among the 42 analyzed patients, the methylprednisolone and dexamethasone groups exhibited significant increases in troponin I and CRP levels (p<0.05). In contrast, changes in myocardial contractility pre- and post-surgery remained consistent across both groups—similarly, no substantial difference in ventilator or ICU stay duration. As the conclusion, dexamethasone and methylprednisolone have not given any effect in preventing increases in troponin I, CRP levels and myocardial contractility early after coronary heart surgery.
O caráter político da especificidade da educação
Authors: Duarte Newton , Silva Efrain Maciel e , Duarte Elaine Cristina Melo
Published: May 2024

A tese de Saviani sobre o caráter político da socialização do conhecimento pela escola sempre encontrou fortes resistências. Argumenta-se nesse artigo que isso decorre de visões pragmáticas, instrumentais, subjetivistas e relativistas do conhecimento.
Escola e democracia, extensão universitária e a formação de professores no Brasil
Authors: Pereira Rosimeri da Silva , Alves Dalton José
Published: May 2024

Considerando a diversidade de conhecimentos teóricos e operacionais que atravessam a formação docente no Brasil, a Extensão se efetua como um dos instrumentos fundamentais no campo de ações  teórico-práticas, atentas ao movimento de transformação do real. Se esse trabalho é o que dá sentido à prática educativa fundada nos princípios do materialismo histórico-dialético, ganha relevo o estudo de caso da obra “Escola e Democracia” e sua relação com a história de organização e funcionamento do Grupo de Estudos da Pedagogia Histórico-Crítica, sediado na Universidade Federal do Estado do Rio de Janeiro (GEPHC/UNIRIO). As evidências identificadas nesta investigação confirmam a relevância das ações desse Grupo de Estudos, considerando o fomento de espaços de debates e publicações decorrentes deste núcleo extensionista atento a um dos fundamentos da obra “Escola e Democracia” que é a defesa da educação escolar como instrumento da transformação social.
Gobierno Milei en Argentina
Authors: Rojas Gonzalo Adrian
Published: May 2024

El Gobierno Milei en Argentina asumió el 10 de diciembre de 2023. El marco internacional es imperialista, un contexto de crisis, guerras y que abre la posibilidad de revoluciones. Una crisis general de capitalismo que se expresa con crisis orgánicas en varios países, como Argentina. Aparece una nueva extrema derecha vinculada a fenómenos internacionales como Trump (Estados Unidos) o Bolsonaro (Brasil)El gobierno Milei se inicia con tres ataques contra los trabajadores y los sectores populares articulando un decreto de necesidad y urgencia, la ley denominada “ómnibus”y un protocolo represivo para impedir de hecho las manifestaciones contrarias generando conflictividad social. En este articulo intentaremos caracterizar al gobierno de extrema derecha de Milei, inicialmente como un intento de construir una dictadura comisarial en términos del Carl Scmitt de la república de Weimar y sus consecuencias para la educación y las libertades democráticas. De forma específica enfocaremos en tres niveles, los ataques: Conicet, que es la política científica del país, el presupuesto educativo de las universidades públicas y el salario de los docentes.
Ethnocentrism, Intergroup Anxiety and Willingness to Communicate Between Cultures: A Study on Javanese and Madurese Ethnic Students
Authors: Abrorry Lucky , Saidah Siti Kamilatus , Asyraf M. Fahmi Aufar , Thohar Syafruddin Faisal , Wahyuni Endang
Published: May 2024

Inter-ethnic harmony needs to continue to be maintained for the sake of national and state life. This harmony starts from the willingness to inter-cultural communication. This research aims to investigate relationship between ethnocentrism, intergroup anxiety and willingness to communicate between cultures and examine differences in terms of gender and ethnicity. Using a correlational research design, this research involved 172 student respondents at UIN Sunan Ampel Surabaya with 97 Javanese ethnic backgrounds and 75 Madurese students who were selected using a purposive sampling technique. Data collection was conducted using a questionnaire. The SFGENE-7 scale was used to measure the level of entocentrism, while the Greenland Group Anxiety Scale was used to measure intergroup anxiety, and the IWTC scale was used to measure the willingness to communicate between cultures. The results of this study indicate that ethnocentrism and intergroup anxiety have a significant negative relationship with willingness to communicate interculturally. Furthermore, there were no significant differences in the three variables tested in terms of ethnicity and gender.
Learn to Fly. Together
Authors: Wuttunee Wanda
Published: May 2024

We are so excited to help you Learn to Fly. Together.
This is the first online issue for our journal. I want to share a bit of our journey with you and acknowledge all of the people who have contributed to this wonderful event. But first, I would like to encourage you to dig into the stories that are shared in this issue. JAED editorial board members and staff are dedicated to your success – in your family, your community and our place in Canada.
PERSPECTIVAS ALTERNATIVAS PARA O FUTURO DO DESIGN COM ÊNFASE SOCIOAMBIENTAL.
Authors: Abreu Garcia Natalí , Franzato Carlo
Published: May 2024

Neste artigo são apresentadas as origens e transformações do design moderno, que tem seu surgimento na Europa e foi inicialmente vinculado ao processo de industrialização. Apresentamos também a crítica de visionários como Morris, Papanek, Manzini, Grupo Regenesis e Escobar, que propõem uma reflexão em direção às questões socioambientais. Através de uma articulação entre propostas contemporâneas pretende-se fomentar a reinvenção dos métodos projetuais do design, guiados por uma visão de mundo orgânica, ecológica e processual, em que o designer possa transcender a sua função como mero executor de lógicas capitalistas, para tornar-se um agente fundamental na transição social rumo à regeneração e saúde ecossistêmica.
Zinc-ion battery with non-aqueous electrolyte and zinc-manganese spinel positive electrode
Authors: Siamionau U. V. , Aniskevich Y. M. , Ivanchanka A. R. , Ragoisha G. A. , Kulak A. I. , Streltsov E. A.
Published: May 2024

Zinc manganite spinel powder specific surface area was found to increase by an order of magnitude via a treatment with sulfuric acid. The specific surface area, determined by nitrogen adsorption, correlates with the specific capacity of zinc manganite spinel positive electrodes. Zinc manganite spinel subjected to a controllable acidic treatment is a promising material for the non-aqueous zinc-ion batteries.
Efficacy of a new system of targeted delivery of tenecteplase in acute myocardial infarction in an in vivo experiment
Authors: Adzerikho I. Е. , Agabekov V. E. , Vladimirskaya Т. Е. , Dubatouka К. I. , Zhilkevich А. V.
Published: May 2024

A new system of targeted delivery of tissue plasminogen activator tenecteplase for restoration of coronary blood flow in acute myocardial infarction in animal experiments was developed.

The new system of targeted delivery of fibrinolytic consists of native (“free”) and encapsulated (“bound”) tenecteplase in liposomes, in the percentage ratio (60 and 40 %, respectively), which are conjugated through carboxylated dextran with fibrin-specific monoclonal antibodies Fnl-3C.

The physicochemical characteristics of the obtained liposomes conjugated with fibrin-specific monoclonal antibodies (immunoliposomes) with tenecteplase were determined: immunoliposomes have a hydrodynamic diameter of ~76‒77 nm, a zeta potential of ~(‒33) mV, a polydispersity index of ~0.55. Modification of liposomes with fibrin-specific monoclonal antibodies does not alter thrombolytic activity.

When using immunoliposomes the survival rate of animals with acute myocardial infarction is ~90 %, liposomal and native form of the drug ‒ 80 %.

The use of immunoliposomal delivery system in animals with acute myocardial infarction leads to an increase in the free lumen of the infarct-related artery (p < 0.05) by 26 % compared to the liposomal delivery system and by 46 % compared to native tenecteplase. At the same time, the mass of ischemic myocardium on the background of thrombolytic therapy with>< 0.05) by 26 % compared to the liposomal delivery system and by 46 % compared to native tenecteplase. At the same time, the mass of ischemic myocardium on the background of thrombolytic therapy with immunoliposomes decreases (p < 0.05) by 16 % in rats in comparison with the liposomal system and by 26 % in comparison with native tenecteplase. The new system of targeted delivery of tenecteplase provides effective and safe thrombolysis in animal experiment> < 0.05) by 16 % in rats in comparison with the liposomal system and by 26 % in comparison with native tenecteplase.

The new system of targeted delivery of tenecteplase provides effective and safe thrombolysis in animal experiment.
Molecular docking of orphan receptors with fatty acid amide
Authors: Doronkina А. S. , Rudak А. А. , Zhavoronok I. Р. , Bogdan V. G.
Published: May 2024

One of the promising directions for development of new pharmacological drugs for analgesia and other consequences of peripheral nerve damage is the study of the physiological effects of fatty acid amides. The potential selectivity of G-protein receptor antagonists has been evaluated using molecular docking and quantum chemistry methods, and its complexes with fatty acid amides have been constructed. As a result of docking, it was found that PSB-CB5 is a selective antagonist for GPR18 receptors, and O-1918 is a selective antagonist for GPR55. It was found that stable complexes are formed between fatty acid amides (REA, SEO) and orphan receptors (GPR 18, GPR55). Numerous van der Waals contacts and hydrogen bonds play a major role in the interaction of these compounds with receptors.
Biological potential of a genetic engineering construction encoding the gene for the human vascular endothelium growth factor
Authors: Bogdan V. G. , Poleshko А. G. , Misiukevich А. Yu. , Smirnov А. А. , Sukhaveyeva S. V. , Yantsevich А. V.
Published: May 2024

The high biological potential of the developed genetically engineered plasmid construct pcDNATM3.1(–) VEGF165 has been established. It has been proven to induce a significant increase in the expression of the gene VEGF165 in mesenchymal multipotent stromal cells and human endothelial cells and to increase the production of the VEGF165 protein by cells. The identified temporary functional activity of the genetically engineered construct in cells and the absence of genotoxic effects minimize the likelihood of oncotransformation.

The created genetically engineered vector construct pcDNATM3.1(–) VEGF165 can be used to develop a gene therapy drug model that promotes angiogenesis in vivo in ischemic tissues.
Directions for increasing the efficiency of fodder production in agricultural organizations of Belarus
Authors: Loban A.
Published: May 2024

The main directions of fodder production development according to the state agrarian policy are determined. The dependence between fodder supply and the number of animals is revealed. The level of forage production intensification is determined taking into account the volume of organic and mineral fertilizers application for fodder crops and the amount of machinery in agricultural organizations. The significance of cultivation of high-protein crops as a promising direction of increasing the efficiency of fodder production is substantiated.
Penguatan Peran Kader tentang Pentingnya Pencegahan Stunting pada 1000 HPK
Authors: Novianti Siti , Gustaman Rian Arie , Lina Nur , Maywati Sri
Published: May 2024

Stunting masih  menjadi  masalah  kesehatan  global.  Prevalensi  stunting  di Indonesia masih tinggi dan merupakan  masalah kesehatan masyarakat. Pemerintah memiliki target penurunan angka stunting menjadi 14% pada tahun 2024. Upaya pencegahan dan penanggulangan stunting memerlukan keterlibatan semua pihak, termasuk perguruan tinggi. Kota Banjar merupakan salah satu lokus stunting di Jawa Barat, dan pada tahun 2022 terdapat kerjasama antara BKKBN dan Universitas Siliwangi dalam upaya penanggulangan stunting di kota Banjar. Bentuk kerjasama yang dilakukan antara lain pelaksanaan kegiatan KKN tematik di kota Banjar dengan tema khusus stunting. Adapun kontribusi Program Studi Kesehatan Masyarakat Fakultas Ilmu Kesehatan adalah melalui pelaksanaan PBL 1 dan 2 di  kota Banjar, khususnya  di kelurahan Banjar, Mekarsari dan Situbatu. Selama dua tahun terakhir, lokasi tersebut menjadi laboratorium lapangan bagi mahasiswa untuk pelaksanaan pendidikan dan pengajaran maupun penelitian. Kegiatan tridarma dosen lainnya yaitu pengabdian masyarakat akan dilaksanakan melalui kegiatan yang berjudul Penguatan Peran Kader dalam Meningkatkan Kualitas Maternal sebagai Upaya Pencegahan Stunting pada 1000 Hari Pertama Kehidupan (HPK) melalui skema Pengabdian Masyarakat Program  Unggulan  Program  Studi  (PbM-PUPS). Kegiatan ini terdapat dua mitra yaitu Kepala Kelurahan Banjar dan Kelurahan Mekarsari. Sasaran dari kegiatan pengabdian adalah kader kesehatan sebanyak 36 orang. Metode yang dilakukan yaitu Training of Trainer (ToT) pada kader tentang materi  pendekatan  siklus  hidup  dalam  pencegahan  stunting  dan pelatihan kader pendamping ibu hamil dalam pencegahan stunting 1000 HPK. Dilakukan analisis untuk menguji perbedaan pengetahuan sebelum dan sesudah pendidikan kesehatan dengan uji Wilcoxon, dan hasil analisis menunjukkan tidak ada beda pengetahuan sebelum dan sesudah pendidikan kesehatan (nilai p>0,005).
Peran Mediasi Kinerja Perawat Pada Pengaruh Kepemimpinan Transformational Manajer Terhadap Medication Safety Di Ruang Perawatan Inap Rumah Sakit Pekanbaru
Authors: Putra Andika Eka
Published: May 2024

Latar Belakang - Keamanan pasien khususnya keamanan obat (medication safety) sangat dibutuhkan pasien dalam pelayanan kesehatan di rumah sakit. Medication safety merupakan fungsi dari kinerja perawat. Hal ini karena ketepatan pemberian obat merupakan alah satu bentuk kinerja perawat. Kepemimpinan transformasional manajer berperan penting dalam peningkatan kinerja perawat dan medication safety.Tujuan - Tujuan penelitian ini adalah untuk menganalisis dan menjelaskan peran mediasi kinerja perawat pada pengaruh kepemimpinan transformasional manajer perawat terhadap medication safety.Desain / metodologi / pendekatan – Penelitian merupakan penelitian kausal dengan pendekatan kuantitatif. Populasi dalam penelitian ini adalah tenaga medis yang bekerja di Rumah Sakit Swasta Pekanbaru. Sampel sejumlah 96 tenaga medis dan diambil dengan convenience sampling. Pengumpulan data dilakukan dengan kuesioner. Teknik analisis data dilakukan dengan Partial Least Square-Structural Equation Modeling (PLS-SEM).Temuan – Hasil penelitian menunjukkan bahwa: 1) kepemimpinan transformasional manajer perawat berpengaruh positif terhadap kinerja perawat; 2) kepemimpinan transformasional manajer perawat berpengaruh positif terhadap medication safety; 3) kinerja perawat berpengaruh positif terhadap medication safety; dan 4) kinerja perawat berperan dalam memediasi pengaruh kepemimpinan transformasional manajer perawat terhadap medication safety. Implikasi penelitian – Penelitian ini berkontribusi pada referensi Sumber Daya Manusia terkait peran mediasi kinerja pada pengaruh kepemimpinan transformasional terhadap medication safety. Hasil penelitian juga dapat menjadi bahan pertimbangan manajemen rumah sakit dalam membuat kebijakan terkait dengan peningkatan medication safety.Batasan penelitian – kinerja perawat dan medication safety hanya dinilai berdasarkan sudut pandang perawat dan tidak mencakup sudut pandang manajer. Kata kunci : Kepemimpinan transformasional, Kinerja, Medication Safety
Kejadian Mortalitas Wanita dengan Kanker Payudara Berdasarkan Indeks Massa Tubuh (BMI): Tinjauan Naratif
Authors: Dahliana Anita , Sukmantoro Agung Anjar , Suryadinata Rivan Virlando , Wahyuni Titin , Aditya Dwi Martha Nur
Published: May 2024

Breast cancer is the most common cancer found in women of all types of cancer in the world. The relationship between body mass index and the death rate from breast cancer in women has drawn attention recently. This study sought to ascertain the relevance of the variation in death rates between women with breast cancer who had a normal body mass index (BMI) and those who had a BMI of ≥25. Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) references were used to guide the systematic review process in this investigation. The Newcastle-Ottawa Scale for cohort design studies and the Robins-I test for single-arm experimental design studies were used to assess the quality of the articles. The data source consisted of 142 Pubmed publications published between 2016 and 2023. The analysis's findings revealed differences between the five publications that discussed the connection between obesity and breast cancer.  The development of breast cancer is linked to an increase in leptin and estrogen, which is consistent with an increase in fat. It is concluded that individuals with a body mass index (BMI) of ≥ 25 had a poorer chance of surviving breast cancer than patients with a normal BMI.
Kepatuhan Dokter dalam Pengisian Rekam Medis di Indonesia: Sebuah Telaah Sistematis
Authors: Lavender Inneke Elysia
Published: May 2024

Pendahuluan. Rekam medis merupakan suatu kumpulan catatan dan informasi lengkap terkait riwayat kesehatan pasien. Akan tetapi, di Indonesia sendiri masih banyak ditemukan rekam medis yang tidak terisi dengan baik dan benar. Tujuan penelitian ini adalah untuk mengidentifikasi faktor yang mempengaruhi kepatuhan tenaga kesehatan dalam pengisian rekam medis di Indonesia. Metode Penelitian. Penelitian ini menggunakan systematic review dengan pencarian artikel yang dilakukan selama 2 minggu (Juni-Juli 2023). Proses penelusuran artikel melalui database jurnal yang meliputi: PubMed, ScienceDirect, Google Scholar dan Portal Garuda. Kriteria inklusi pada penelitian ini adalah artikel full paper dengan metode penelitian belah lintang dengan tahun artikel dipublish tahun 2017-2023. Hasil Penelitian. Hasil yang ditemukan pada sintesis data primer adalah ketidakpatuhan dokter dalam pengisian rekam medis yakni memiliki rata-rata 79,5%. Rata-rata penyebab dokter tidak patuh dalam pengisian rekam medis adalah dikarenakan pengetahuan, komitmen, sikap, motivasi, beban kerja yang tinggi, tempat kerja yang tidak nyaman, insentif yang rendah dan faktor sosiodemografi. Kesimpulan. Faktor yang mempengaruhi ketidakpatuhan dalam pengisian rekam medis rata-rata disebabkan oleh pengetahuan, komitmen, sikap, motivasi dan beban kerja yang tinggi. Introduction: Medical records are comprehensive documents that contain detailed information pertaining to a patient's medical background. However, in Indonesia, many medical records are still need to be filled properly and correctly. The objective of this study was to ascertain the determinants that impact physician compliance to completing medical records in Indonesia.Research Methods. This study used a systematic review research. The process of finding primary studies was done for two weeks (June-July 2023) through journal databases, including PubMed, ScienceDirect, Google Scholar, and Garuda. The inclusion criteria for this study include full-text studies applying a cross-sectional research design, published between 2017 and 2023. Results. Physician noncompliance in filling up medical records, with an average of 79.5%, was discovered in the synthesis of primary data. The average causes of doctors' noncompliance in filling out medical records are knowledge, commitment, attitude, motivation, workload, uncomfortable workplace, low incentives and sociodemographic factors.Conclusion. The lack of compliance among physicians in documenting medical records can be attributed to factors such as limited knowledge, poor commitment, negative attitudes, low motivation, and high workload.
Pelatihan Manajemen Pariwisata di BUMDES Bermi Indah dalam Rangka Peningkatan Kinerja Sumber Daya Manusia
Authors: Sulianti K. Tobing Diana , Krisnabudi Gede , Handriyono Handriyono
Published: May 2024

Pelatihan manajemen pariwisata di BUMDes Bermi Ecopark Kota Lumajang, dapat membantu para karyawan dalam merencanakan, mengkoordinasikan, mengarahkan dan mengendalikan berbagai aspek yang berkaitan dengan destinasi wisata. Ini mencakup pemahaman yang lebih baik tentang fungsi-fungsi dan strategi bisnis, manajemen pemasaran, manajemen keuangan, serta pemeliharaan dan pengembangan fasilitas. Peningkatan kapasitas sumber daya manusia, termasuk pelatihan bagi karyawan dalam memberikan pelayanan yang berkualitas dan mendukung konsep konservasi alam, juga akan memperkuat Bermi Ecopark dalam memenuhi harapan wisatawan. Pelatihan ini bertujuan untuk Pelatihan bertujuan untuk meningkatkan kinerja individu sehingga mereka dapat memberikan kontribusi yang lebih besar terhadap tujuan organisasi. Dampak pengabdian kepada masyarakat ini adalah dengan adanya pelatihan, organisasi dapat memperkuat budaya kerja yang positif, seperti kerjasama tim, komunikasi terbuka, dan pembelajaran berkelanjutan.
Peranan Terapi Noninvasive Brain Stimulation rTMS (Repetitive Transmagnetic Stimulation) Pada Proses Pemulihan Pasien Stroke
Authors: Susilawati Ni Nyoman Ayu , Herpan Syafii Harahap  , Amanda Tiksnadi
Published: May 2024

Stroke merupakan penyakit neurologis yang sering dijumpai di masyarakat, penyebab disabilitas dan mortalitas kedua setelah penyakit jantung (Wang dkk, 2022). Berbagai defisit neurologis dapat dijumpai pada kejadian pasca stroke seperti kelemahan motorik, gangguan fungsi kognitif, gangguan fungsi berbahasa dan gangguan fungsi menelan Disabilitas yang terjadi disebabkan karena kerusakan sistem saraf pusat (SSP) terutama bagian korteks serebri yang sel neuronnya mengalami kematian/kerusakan. Hal  iniakan  mengakibatkan terjadinya ketidakseimbangan fungsi (atau elektrikal) di area sekitar lesi  maupun di area sekunder atau bahkan area homotopik kontralateral (berupa hipereksitasi atau hipoeksitasi Repetitive transmagnetic stimulation (rTMS) merupakan salah satu modalitas terapi stimulasi otak yang berkembang paling pesat sebagai terapi komplementer pemulihan fungsi pasca stroke karena keunggulannya mampu merubah keseimbangan atau memperbaiki keseimbangan fungsi otak yang berlebihan atau kekurangan dengan pemberian stimulasi langsung pada sel saraf di otak secara non-invasif dan lebih terfokus (terbatas) terhadap target area sesuai patofisologi yang terjadi seperti di daerah korteks motorik primer dan asosiasi, korteks prefronal, korteks dorsolateral prefrontal, girus frontal inferior, korteks mylohyoid dan bagian otak lainnya.  Beberapa studi metaanalisis stimulasi otak dengan rTMS pada pasien stroke menunjukan perbaikan signifikan terhadap fungsi motorik, kognitif, berbahasa dan menelan. Studi oleh Veldema dan  Gharabaghi (2022) menunjukan perbaikan fungsi motorik  dengan stimulasi bilateral rTMS, studi oleh Li dkk (2021) stimulasi LF-rTMS  di area DLPFC kontralateral memperbaiki fungsi visuospasial, memori dan atensi dan stimulasi DLPFC kiri dapat memperbaiki fungsi penamaan dan pengolahan kata-kata (Naeser dkk, 2020). Yang dkk (2021) menemukan terapi rTMS di korteks esofagus dan mylohyoid meningkatkan fungsi menelan.
The Update on the Role of Cesarean Myomectomy in an Old Primigravida with Huge and Painful Myoma: a Challenging Case for Fertility-Preserving Surgery
Authors: Sitepu Muhammad Freddy Candra , Ahmad Fadhli Bustomi  , Ahmad Fadhli Bustomi  , Maskasoni  , I Komang Yogi Arta Suarlin  , Gusti Anom Christyandi Ramarantika  , Abiyyu Didar Haq
Published: May 2024

Abstract
There is no established protocol for reducing maternal and perinatal morbidities in myoma during pregnancy. The opinions regarding performing myomectomy during cesarean section have been inconsistent and hot topic of discussion. The recent trends regarding the pro and cons outcomes are caused by potential risk of massive hemorrhage, repeat operation and anesthesia, less time away from work, prolong duration of operation and hospital stay, need of transfusion, increased overall cost, and morbidity. We presented a case of 42-year-old primigravida at 37-38 weeks of singleton live pregnancy with intramural myoma, and then performed successfully cesarean section and myomectomy without complication. The results of the operation showed a safe outcome when performed by an experienced obstetrician and selective case, and helped maintain fertility sparing in the future.
Keywords: Uterine myoma, Cesarean myomectomy, Old primigravida