bluuebunny/crossref_metadata_2025 huggingface dataset:
Efficacy Studies against PCV-2 of a New Trivalent Vaccine including PCV-2a and PCV-2b Genotypes and Mycoplasma hyopneumoniae When Administered at 3 Weeks of Age
Authors: Pleguezuelos Patricia , Sibila Marina , Ramírez Carla , López-Jiménez Rosa , Pérez Diego , Huerta Eva , Llorens Anna Maria , Pérez Mónica , Correa-Fiz Florencia , Mancera Gracia José Carlos , Taylor Lucas P. , Smith Jennifer , Bandrick Meggan , Borowski Stasia , Saunders Gillian , Segalés Joaquim , López-Soria Sergio , Fort Maria , Balasch Mónica
Published: December 2022

This study aimed to evaluate the efficacy of a new trivalent vaccine containing inactivated Porcine Circovirus 1-2a and 1-2b chimeras and a Mycoplasma hyopneumoniae bacterin administered to pigs around 3 weeks of age. This trivalent vaccine has already been proved as efficacious in a split-dose regimen but has not been tested in a single-dose scenario. For this purpose, a total of four studies including two pre-clinical and two clinical studies were performed. Globally, a significant reduction in PCV-2 viraemia and faecal excretion was detected in vaccinated pigs compared to non-vaccinated animals, as well as lower histopathological lymphoid lesion plus PCV-2 immunohistochemistry scorings, and incidence of PCV-2-subclinical infection. Moreover, in field trial B, a significant increase in body weight and in average daily weight gain were detected in vaccinated animals compared to the non-vaccinated ones. Circulation of PCV-2b in field trial A and PCV-2a plus PCV-2d in field trial B was confirmed by virus sequencing. Hence, the efficacy of this new trivalent vaccine against a natural PCV-2a, PCV-2b or PCV-2d challenge was demonstrated in terms of reduction of histopathological lymphoid lesions and PCV-2 detection in tissues, serum and faeces, as well as improvement of production parameters.
Parental Seasonal Influenza Vaccine Hesitancy and Associated Factors in Shanghai, China, during the COVID-19 Pandemic: A Cross-Sectional Study
Authors: Fan Jingyi , Ye Chuchu , Wang Yuanping , Qi Hui , Li Dong , Mao Jun , Xu Hongmei , Shi Xiaojin , Zhu Weiping , Zhou Yixin
Published: December 2022

Background: Seasonal influenza may overlap with the COVID-19 pandemic, and children are one of the priority populations for influenza vaccination in China, yet vaccine coverage has been low. This study aimed to investigate the extent of parental influenza vaccine hesitancy (IVH) and to explore the associated factors. Methods: The study was conducted in Shanghai, China, from 1 June 2022 to 31 July 2022, using an anonymous questionnaire to survey a random sample of parents of children aged six months to 14 years. Binary logistic regression models were used to identify factors associated with IVH. Results: Of the 5016 parents, 34.05% had IVH. Multivariate analysis showed that after adjustment for non-modifiable markers (i.e., sociodemographic, health status, and past vaccination status), being affected by negative influenza vaccine news and having higher “complacency” were positively associated with parental IVH. Higher knowledge of influenza vaccination, being recommended by healthcare workers (HCWs), people around having a positive attitude toward influenza vaccine and having higher levels of “confidence” and “convenience” were negatively associated with parental IVH. Conclusions: In China, public health education aimed at modifying vaccination-related attitudes and beliefs, as well as knowledge and societal influences, could help reduce influenza vaccination hesitancy.
Antibodies Induced by Homologous or Heterologous Inactivated (CoronaVac/BBIBP-CorV) and Recombinant Protein Subunit Vaccines (ZF2001) Dramatically Enhanced Inhibitory Abilities against B.1.351, B.1.617.2, and B.1.1.529 Variants
Authors: Xu Xuesong , Hong Yi , Chen Erjing , Wang Yaping , Ma Biao , Li Jiali , Su Wei , Zhou Yuxin , Zhang Mingzhou
Published: December 2022

Safe and effective vaccines for Corona Virus Disease 2019 (COVID-19) can prevent the virus from infecting human populations and treat patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). In this study, we discuss the inhibitory abilities of primary and booster vaccine-induced antibodies inhibitory ability toward the SARS-CoV-2 wild-type strain, as well as B.1.1.7, B.1.351, P.1, B.1.617.2, and B.1.1.529. We confirmed these antibodies had the strongest inhibitory effects on the wild-type strain and cross-inhibition activities against other mutant strains after two inactivated vaccine doses. However, the B.1.351, B.1.617.2 and B.1.1.529 mutants exhibit antibody resistance in the vaccine serum. Antibodies induced by homologous inactivated vaccines (n = 92) presented more effective inhibition against tested SARS-CoV-2 strains (p < 0.0001), especially B.1.351, B.1.617.2, and B.1.1.529 mutant strains, which had strong immune escape characteristics. In addition, a heterologous booster vaccination (n = 50) of a protein subunit vaccine ZifiVax (ZF2001) significantly restored humoral immune responses and even showed an increasing response against wild-type, B.1.351, B.1.617.2, and B.1.1.529 than homologous inactivated vaccines. Our analysis of the humoral immune response elicited by the different vaccine regimens, including inhibiting antibodies, indicated that a booster, whether homologous or heterologous, could be essential for achieving greater efficacy against SARS-CoV-2.
Biothermodynamics of Viruses from Absolute Zero (1950) to Virothermodynamics (2022)
Authors: Popovic Marko
Published: December 2022

Biothermodynamics of viruses is among the youngest but most rapidly developing scientific disciplines. During the COVID-19 pandemic, it closely followed the results published by molecular biologists. Empirical formulas were published for 50 viruses and thermodynamic properties for multiple viruses and virus variants, including all variants of concern of SARS-CoV-2, SARS-CoV, MERS-CoV, Ebola virus, Vaccinia and Monkeypox virus. A review of the development of biothermodynamics of viruses during the last several decades and intense development during the last 3 years is described in this paper.
Does Vaccination Protect against Human Papillomavirus-Related Cancers? Preliminary Findings from the United States National Health and Nutrition Examination Survey (2011–2018)
Authors: Issanov Alpamys , Karim Mohammad , Aimagambetova Gulzhanat , Dummer Trevor
Published: December 2022

Most oropharyngeal and anogenital cancers are caused by human papillomavirus (HPV). Although HPV vaccines showed high efficacy against oropharyngeal and anogenital HPV infections, and cancer precursors in randomized clinical trials, there are limited data on the effectiveness of HPV vaccination against HPV-related cancers. We aimed to evaluate the association of HPV vaccination with HPV-related cancers among a nationally representative sample of United States adults, aged 20–59 years. In a cross-sectional study combining four cycles from the National Health and Nutrition Examination Survey, from 2011 through 2018, we used a survey-weighted logistic regression model, propensity score matching and multiple imputations by chained equations to explore the association of HPV vaccination with HPV-related cancers. Among 9891 participants, we did not find an association of HPV vaccination with HPV-related cancers (adjusted OR = 0.58, 95% CI 0.19; 1.75). Despite no statistically significant association between HPV vaccination and HPV-related cancers, our study findings suggest that HPV-vaccinated adults might have lower odds of developing HPV-related cancers than those who were not vaccinated. Given the importance of determining the impact of vaccination on HPV-related cancers, there is a need to conduct future research by linking cancer registry data with vaccination records, to obtain more robust results.
COVID-19 Vaccination among a Population Experiencing Homelessness: A Survey in Italy
Authors: Della Polla Giorgia , Miraglia del Giudice Grazia , Napoli Annalisa , Folcarelli Lucio , Angelillo Italo Francesco
Published: December 2022

The purposes of this cross-sectional study were to determine the knowledge, attitudes, and behaviors about COVID-19 and its vaccination among 313 individuals experiencing homelessness in Italy and to identify the associated factors. A total of 20.5% identified the virus as a causative agent for COVID-19 and 44.2% identified how the SARS-CoV-2 infection wastransmitted. Those living in homeless shelters were more likely to have this knowledge. Concerns about the safety of the COVID-19 vaccine werehigher in those who were younger, with secondary school as the highest level of education, who practiced Christianity, and who did not believe that COVID-19 was a severe disease. A total of 83.9% received the vaccination. Those who were older, who had correct knowledge, whoperceived to be at a higher risk of getting the disease, and who had a lower concern about the vaccine side effects were more likely to have received the vaccination. The primary reasons for accepting the COVID-19 vaccine were that it wasa preventive measure and that it wasmandatory; those unvaccinated indicated, as the main reasons, a fear of side effects and that it wasnot useful. A relationship and communication between healthcare professionals and this hard-to-reach population are needed, with the implementation of educational and information programs.
Thermophilic Filamentous Fungus C1-Cell-Cloned SARS-CoV-2-Spike-RBD-Subunit-Vaccine Adjuvanted with Aldydrogel®85 Protects K18-hACE2 Mice against Lethal Virus Challenge
Authors: Nechooshtan Ram , Ehrlich Sharon , Vitikainen Marika , Makovitzki Arik , Dor Eyal , Marcus Hadar , Hefetz Idan , Pitel Shani , Wiebe Marilyn , Huuskonen Anne , Cherry Lilach , Lupu Edith , Sapir Yehuda , Holtzman Tzvi , Aftalion Moshe , Gur David , Tamir Hadas , Yahalom-Ronen Yfat , Ramot Yuval , Kronfeld Noam , Zarling David , Vallerga Anne , Tchelet Ronen , Nyska Abraham , Saloheimo Markku , Emalfarb Mark , Ophir Yakir
Published: December 2022

SARS-CoV-2 is evolving with increased transmission, host range, pathogenicity, and virulence. The original and mutant viruses escape host innate (Interferon) immunity and adaptive (Antibody) immunity, emphasizing unmet needs for high-yield, commercial-scale manufacturing to produce inexpensive vaccines/boosters for global/equitable distribution. We developed DYAI-100A85, a SARS-CoV-2 spike receptor binding domain (RBD) subunit antigen vaccine expressed in genetically modified thermophilic filamentous fungus, Thermothelomyces heterothallica C1, and secreted at high levels into fermentation medium. The RBD-C-tag antigen strongly binds ACE2 receptors in vitro. Alhydrogel®‘85’-adjuvanted RDB-C-tag-based vaccine candidate (DYAI-100A85) demonstrates strong immunogenicity, and antiviral efficacy, including in vivo protection against lethal intranasal SARS-CoV-2 (D614G) challenge in human ACE2-transgenic mice. No loss of body weight or adverse events occurred. DYAI-100A85 also demonstrates excellent safety profile in repeat-dose GLP toxicity study. In summary, subcutaneous prime/boost DYAI-100A85 inoculation induces high titers of RBD-specific neutralizing antibodies and protection of hACE2-transgenic mice against lethal challenge with SARS-CoV-2. Given its demonstrated safety, efficacy, and low production cost, vaccine candidate DYAI-100 received regulatory approval to initiate a Phase 1 clinical trial to demonstrate its safety and efficacy in humans.
Widening Disparities in Teen HPV Vaccinations during COVID-19 Pandemic: A Case Study from Veneto Region (Italy)
Authors: Perin Luca , Dal Zotto Alessandra , Savio Marta , Stano Antonio , Bulegato Lorenzo , Tribbia Luca , Donà Roberta , Tomasi Matilde , Fietta Silvia , Ferro Antonio , Baldo Vincenzo , Saugo Mario , Cocchio Silvia
Published: December 2022

Introduction: In Local Health Unit 7, human papilloma virus (HPV) vaccination campaigns for 12-year-olds have long been implemented by the vaccination services of the Department of Prevention. Due to the pressure of the COVID-19 pandemic on these services, an emergency vaccination campaign was directly managed by primary care pediatricians (PCPs). An initial evaluation of this experience was conducted. Materials and methods: Data on 12-year-olds assisted by PCPs belonging to the 2006 (pre-pandemic) and 2008 (pandemic) birth cohorts were extracted, along with HPV vaccination data. Health district, gender, citizenship, socioeconomic status, and PCPs were evaluated as possible influencing factors in a two-level logistic regression (second level: single PCP). Results: The HPV vaccination gap between males and females increased significantly for the 2008 birth cohort compared to the 2006 birth cohort (11 vs. 4 percentage points). As for PCPs, the vaccination uptake range was 4–71% for the 2008 birth cohort vs. 32–85% for the 2006 cohort. The proportion of variance explained at the second level was overall equal to 9.7% for the 2008 cohort vs. 3.6% for the 2006 cohort. Conclusions: The vaccination campaign carried out during the peak of the COVID-19 pandemic increased the HPV vaccination gaps among Health Districts, genders, and individual PCPs, probably due to a lack of homogeneity in professional practices and attitudes toward HPV vaccination. Catch-up interventions are required in the immediate term, while an equity-lens approach should be taken for reprogramming the vaccination campaign. Greater involvement of schools and families could ensure a more equitable approach and a better uptake.
The COVID-19 Vaccine and Pregnant Minority Women in the US: Implications for Improving Vaccine Confidence and Uptake
Authors: Alcendor Donald J. , Matthews-Juarez Patricia , Smoot Duane , Hildreth James E. K. , Tabatabai Mohammad , Wilus Derek , Brown Katherine Y. , Juarez Paul D.
Published: December 2022

The American College of Obstetricians and Gynecologists (AGOG) recommends the FDA-approved Pfizer and Moderna mRNA COVID-19 vaccines and boosters for all eligible pregnant women in the US. However, COVID-19 vaccine confidence and uptake among pregnant minority women have been poor. While the underlying reasons are unclear, they are likely to be associated with myths and misinformation about the vaccines. Direct and indirect factors that deter minority mothers in the US from receiving the mRNA COVID-19 vaccines require further investigation. Here, we examine the historical perspectives on vaccinations during pregnancy. We will examine the following aspects: (1) the influenza and tetanus toxoid, reduced diphtheria toxoid, and acellular pertussis (Tdap) vaccinations during pregnancy; (2) the exclusion of pregnant and lactating women from COVID-19 vaccine trials; (3) COVID-19 vaccine safety during pregnancy, obstetric complications associated with symptomatic COVID-19 during pregnancy, COVID-19 vaccine hesitancy among pregnant minority women, and racial disparities experienced by pregnant minority women due to the COVID-19 pandemic as well as their potential impact on pregnancy care; and (4) strategies to improve COVID-19 vaccine confidence and uptake among pregnant minority women in the US. COVID-19 vaccine hesitancy among minority mothers can be mitigated by community engagement efforts that focus on COVID-19 vaccine education, awareness campaigns by trusted entities, and COVID-19-appropriate perinatal counseling aimed to improve COVID-19 vaccine confidence and uptake.
Resistance of Field-Isolated Porcine Epidemic Diarrhea Virus to Interferon and Neutralizing Antibody
Authors: Park Jung-Eun , Shin Hyun-Jin
Published: December 2022

Variant porcine epidemic diarrhea virus (PEDV), belonging to the genogroup G2b, has higher pathogenicity and mortality than classical PEDV, belonging to the genogroup G1a. To understand the pathogenesis of the G2b PEDV, we examined the resistance of the G2b PEDV to interferon (IFN) and neutralizing antibodies, which are important for controlling PEDV infection. We found that the G2b PEDV showed higher resistance to IFN than G1a PEDV. The G1a PEDV could replicate in IFN-deficient Vero cells, but not in IFN-releasing porcine alveolar macrophages, whereas the G2b PEDV showed similar infectivity in both types of cells. We also found that G2b PEDV was not effectively blocked by neutralizing antibodies, unlike G1a PEDV, suggesting differences in the antigenicity of the two strains. These results provide an understanding of the occurrence of variant PEDV and its pathogenesis.
Role of Multifunctional Water Reservoirs in the Upper Vistula Basin in Reducing Flood Risk
Authors: Woś Krzysztof , Radoń Radosław , Tekielak Tomasz , Wrzosek Krzysztof , Pieron Łukasz , Piórecki Michał
Published: December 2022

Multifunctional flood protection reservoirs of regional importance have been controversial for many years due to their significant environmental impact. The impact is especially observed at the implementation stage. Undeniably, properly managed large water reservoirs are the most effective element of active flood protection and significantly reduce the flood wave, thus limiting losses in housing, infrastructure, industry, or agriculture. At the same time, multifunctional reservoirs pursue other goals that are related to reducing shortages and counteracting the effects of drought, water supply, hydropower, or recreation. In the era of rapidly advancing climate and geopolitical changes, their role seems indispensable when it comes to responsible and coordinated water management in Poland. An open question is how to fully use the potential and to what extent it is possible for the system of reservoirs located on different watercourses to work together in the era of the progressive development of the country resulting in significant changes in land use (sealing large catchment areas) in relation to design assumptions. The article presents an analysis of the work of selected water reservoirs located in the basin of the upper Vistula during the floods that took place in the last decade. On the basis of the obtained conclusions, the authors present recommendations on how to effectively manage the network of reservoirs during a flood while minimizing losses of the water retained in them, which should be used to meet other goals of water management.
Variability of the Carbon Isotope Composition of Peat-Forming Plants during the Biochemical Transformation
Authors: Golovatskaya Evgeniya , Nikonova Liliya , Simonova Galina , Kalashnikova Daria
Published: December 2022

In this study, we describe the variation in δ13C value in the litter of two species of peat-forming plants: Sphagnum fuscum and Eriophorum vaginatum, during 3 years of field decomposition in oligotrophic bog ecosystems drained for the purpose of forest melioration and fire affected and at the stage of post-pyrogenic restoration. Litterbags were periodically retrieved in the autumn and the δ13C value in the residual litter was related to mass loss, litter chemistry, and hydrothermal conditions. Sph. fuscum decomposes much more slowly than E. vaginatum. Low rate of transformation for Sph. fuscum is observed in drained and post-pyrogenic sites, while for E. vaginatum minimal rate of transformation is observed in the native site. During the decomposition of Sphagnum residues, 13C enrichment occurs, and during the decomposition of E. vaginatum, we observed 12C enrichment. The changes in the isotope composition of carbon for investigation sites are insignificant for Sphagnum fuscum, but it was observed for E. vaginatum, the largest of 13C depletion is observed in the drained site (−28.3‰) and minimal in the postpyrogenic site (−27.4‰).
Effects of Bacillus pumilus BP-171 and Carbon Sources on the Growth Performance of Shrimp, Water Quality and Bacterial Community in Penaeus vannamei Culture System
Authors: Wang Mingyang , Liu Yang , Luo Kai , Li Tengfei , Liu Qingbing , Tian Xiangli
Published: December 2022

A strain of Bacillus pumilus BP-171 with the ability of heterotrophic nitrification-aerobic denitrification was isolated from a shrimp culture pond and showed good denitrification ability under laboratory conditions. In order to investigate the effects of strain BP-171 and its combinations with different carbon sources, i.e., poly-3-hydroxybutyrate-co-3-hydroxyvalerate (PHBV) and molasses, on the growth performance of shrimp, water quality and bacterial community in culture system of Penaeus vannamei, this experiment was set up. Four experimental groups were designed, i.e., group B applied with a single B. pumilus BP-171, the BP added with BP-171 and PHBV, the BM added with BP-171 and molasses, and the control DZ without the probiotic and carbon source. The results showed that the specific growth rate, final body weight, gross weight, feed efficiency rate and survival rate of shrimp in the BP and BM groups were better than those in the control (p < 0.05), while the survival rate and gross weight of shrimp in group B were also better than those in the control (p < 0.05). Among them, the best growth performance of shrimp was observed in the group BP. The concentrations of ammonia, nitrite, nitrate and total nitrogen were significantly lower in all treatment groups than in the control (p < 0.05). The lowest concentrations of ammonia and nitrite were found in group B, while those of nitrate and total nitrogen were found in group BP (p < 0.05). The concentrations of dissolved organic carbon and total organic carbon in both BP and BM groups were significantly higher than in group B and the control (p < 0.05). Compared to the control, the abundance and diversity of the bacterial community in water did not change with the addition of probiotics and carbon sources. However, altered structure and predicted function, as well as improved stability of the ecological network of the bacterial community, were observed in water. In view of the above, the addition of B. pumilus BP-171 and PHBV significantly promoted the growth performance of shrimp, effectively improved water quality, and enhanced the stability of the ecological network of bacterial communities in water, which could have great potential for the application in intensive culture of P. vannamei.
Assessment of Chambal River Water Quality Parameters: A MATLAB Simulation Analysis
Authors: Gupta Mukesh Kumar , Kumar Rahul , Banerjee M. K. , Gupta Naveen Kumar , Alam Tabish , Eldin Sayed M. , Khan Mohd Yawar Ali
Published: December 2022

In this research work, environmental monitoring processes and assessments are carried out by the modeling and analysis of the water quality of the Chambal River in the state of Rajasthan. Various samples were collected from different locations along the course of the river flow. This water is used for different kinds of human, animal, and agriculture corp. activities. Comparative analyses were conducted on the water parameters, viz. biochemical oxygen demand, chemical oxygen demand, dissolved oxygen, total coliform, and conductivity, for the of consecutive years 2020 and 2021. A model was developed with the help of MATLAB Simulink software (Version R2019a) to find the causes of oxygen deficiency and reoxygenation in water with time and distance. The results of two consecutive years help to predict the responsible factors for the degradation of the river’s water quality. The water quality modeling and simulation results conclude that the water quality of the Chambal River flowing through Rajasthan can rejuvenate itself during an alarming oxygen deficit within a short period. According to the results of this study, the concentration of dissolved oxygen in the water of the Chambal River is high enough to support the survival of the endangered species that inhabit the area.
Simultaneous Removal of Metal Ions from Wastewater by a Greener Approach
Authors: Ibrahim Lubna A. , El-Sesy Marwa E. , ElSayed ElSayed ElBastamy , Zelenakova Martina , Hlinkova Maria , Mohamed Essam Sh. , Abu-Hashim Mohamed
Published: December 2022

The examination of the performance of raw and immobilized S. (Saccharomyces) cerevisiae in the simultaneous abatement of metal ions from wastewater effluent is the focal point of this article. The optimal storage time for raw and immobilized S. cerevisiae, during which they can be utilized, was estimated. The outcomes revealed that as the initial metal ion concentrations increased, the adsorption capacity improved, while the removal efficiency of S. cerevisiae yeast cells decreased, with the highest uptake obtained at the optimal conditions: pH = 5.0, 2.0 g S. cerevisiae/L, 25 °C, and a contact time of 25 min. The maximum adsorption capacities (qmax) for Pb(II), Cd(II), and Ni(II) ions are shown by Langmuir at 65, 90, and 51 mg/g, respectively. It was discovered that the metal ions’ biosorption reactions were spontaneous and were fitted by the pseudo-second-order model. The mechanisms of the metal ions’ abatement were explained by using XRD (X-ray diffraction), FTIR (Fourier transform infrared spectroscopy), (BET) Brunauer–Emmett–Teller, and TEM (transmission electron microscopy) outputs. EDTA and citric acid can eliminate more than 70 ± 4 and 90 ± 5% of the adsorbed ions, respectively. The experiment of storage demonstrated that the immobilized S. cerevisiae was more stable for 8 months than the raw yeast.
Cross-Priming Approach Induced Beneficial Metabolic Adjustments and Repair Processes during Subsequent Drought in Olive
Authors: Ben Abdallah Mariem , Methenni Kawther , Taamalli Wael , Hessini Kamel , Ben Youssef Nabil
Published: December 2022

Cross-tolerance to abiotic stresses is a typical phenomenon in plants which occurs when exposure to one form of stress confers tolerance to a variety of stresses. Our study aims at investigating whether salinity priming could induce, after a recovery period (2 months), drought tolerance in olive cv. Chétoui. Here, our results revealed that this method of cross-adaptation had further enhanced the olive’s subsequent response to drought. In fact, relative to the non-pretreated plants, the salt-pretreated ones displayed an enhancement in terms of shoot biomass accumulation, photosynthetic performance, water-use efficiency, and hydration status. Furthermore, the attenuation of oxidative stress and the maintenance of structural lipid contents, as well as their fatty acid composition in salt-pretreated plants, also supported the beneficial effect of this method. From our results, it seems that salt priming substantially modulated the physiological and biochemical responses of olive plants to subsequent drought. Accordingly, metabolite adjustments (soluble sugars and proline), the enzymatic antioxidant system (superoxide dismutase (SOD), catalase (CAT), and guaiacol peroxidase (GP) activities) as well as the nonenzymatic one (phenols), and the increase in leaf density together with the raise of structural lipids content, to a lesser extent, seemed to perform a major role in the development of this improved tolerance to drought. The ameliorative response found in salt-primed olive plants, when subsequently exposed to drought, indicates an efficient cross-tolerance reaction. This could be particularly important in the Mediterranean area, where olive orchards are mainly cultivated under dry-land farming management.
METHODICAL OUTLINES OF "ETYMOLOGY" OF ISIDORE OF SEVILLE
Authors: SAYBEKOV M.
Published: December 2022

The article is dedicated to the method of Isidore of Seville and the methodical foundations with their help he wrote his fundamental work. In the preamble, Isidore explained the content of his work: "Etymology is the origin of words, when the essence of a word or a name is revealed through explanation." It was the etymological approach, first applied in "Differentiation", that allowed Isidore to seek out the foundations of being, because he proceeded from the deep interconnection of the word and what it means. Terminological research allowed the use of the mind in  the process of knowing the truth. In "Etymology" it is stated that concepts are not created and do not arise, but only exist and open in the word. It is noted that the concept of encyclopedicism, rooted in the ancient heritage, to some extent removed the contradictions of different levels of culture - material and spiritual, intellectual and covers other activities, which provided his concept of optimistic sound. To the encyclopedic genre "Etymology" can be attributed as a result of the wide coverage of topics and the method of sampling information from other works, primarily - encyclopaedic.
Aprendizaje cooperativo y significativo en el contexto de la educación virtual
Authors: Bustillos Alamo Sprenger Samuel , Araujo Rojas Esther Ruth , Castro Salazar Massiel , Carpio Valencia Fortunato Edmundo , Supo Condori Felipe
Published: December 2022

La pandemia de la COVID-19 ha generado múltiples impactos a nivel educativo, entre los que destaca la necesidad de migrar a una modalidad de enseñanza virtual; sin embargo, las metodologías de enseñanza no han sido adaptadas con la misma facilidad, como es el caso del aprendizaje significativo y el aprendizaje cooperativo. Por tanto, el objetivo de este estudio es comprobar la existencia de una relación entre el aprendizaje cooperativo y sus dimensiones con el aprendizaje significativo en estudiantes. Respecto a la metodología, la investigación sigue un enfoque cuantitativo de tipo básico, una metodología hipotética y deductiva, con diseño no experimental, de corte transversal y nivel correlacional. Asimismo, se utilizó muestra probabilística de 132 alumnos y se emplearon 2 cuestionarios como instrumentos, los cuales fueron validados mediante un juicio de expertos, del mismo se determinó su confiabilidad a través del cálculo del Alfa de Cronbach, luego se analizaron los datos con el software estadístico SPSS 21.0 y Microsoft Excel. Los resultados determinaron que existe una relación positiva y significativa entre el aprendizaje cooperativo y el aprendizaje significativo en los alumnos de la modalidad de enseñanza virtual.
Rastreamento da perda da sensibilidade protetora em pacientes com Diabetes tipo II (tipo 2) por profissionais de saúde
Authors: Mendanha Hiago Marques , Santos Nathália Lagares Milhomem , Mendonça Andressa Piovezan , Ribeiro Otávio Augusto de Paiva , Leitao Luciana Pereira Colares
Published: December 2022

Objetivo: Identificar se os profissionais de saúde, de uma unidade de ESF no município de Marabá-PA, realizam os testes de rastreamento da perda da sensibilidade protetora em pacientes com DM tipo II. Método: Trata-se de um estudo com delineamento observacional do tipo analítico e transversal de abordagem quantitativa por meio de questionário realizado pela Plataforma Digital Google Forms, contendo 17 questões. Resultados: Sobre o conhecimento acerca da PSP, 100% dos participantes afirmaram saber do que se tratava a PSP, sendo que todos (100%) afirmaram que a avaliação neurológica no paciente com DM tipo II tem como principal objetivo identificar a PSP.  Cerca de 83% afirmaram que é recomendado a utilização de ao menos 1 dos 4 testes que o Caderno de Atenção Básica n° 36 recomenda para avaliar a PSP. Todos (100%) os participantes referiram ser importante a aplicação dos testes para identificar a PSP nos pacientes em risco. No entanto, somente 50% dos participantes realizavam os testes em seus pacientes, sendo que 33% desses realizavam a cada 3 meses. Os 50% que afirmaram não realizarem, assinalaram ser a faltar tempo durante as consultas o motivo. Todos os participantes afirmaram não receber nenhum treinamento ou capacitação para aplicar os testes de rastreamento da PSP. Conclusão: Conclui-se que o presente estudo alcançou seu objetivo, sendo identificado que somente 50% dos entrevistados aplicavam tais testes. Espera-se contribuir com a comunidade científica sobre esse tema, já que esse é o primeiro estudo que trata sobre essa temática no município de Marabá/PA, bem como incentivar a elaboração ne novos estudos sobre o tema para investigação e elucidação mais clara acerca do tema.
Analisis Marketing Strategy Melalui Media Sosial pada Produk Premium Leather Bag
Authors: Al’qur’ani Fitri Nur Corry , Amalina Rizqi Maulidyah
Published: December 2022

Marketing Strategy continues to experience development, especially in this digital era. The practice of managing an online store is called a marketing strategy through social media. In terms of the marketing function for fashion products, product samples are needed which are then referred to as product catalogs to support the sustainability of PT. Alra Makmur Cahaya Selaras, which is engaged in fashion products, especially premium leather bag products, carries out these marketing activities on social media applications, which for the past five years are still the applications with the most users, namely Instagram. In its management, PT. Alra Makmur Cahaya Selaras uses Instagram as a place to reach the premium leather bag market segment. The purpose of this study is to analyze marketing strategies through social media, especially on the Instagram application from PT. Alra Makmur Cahaya Selaras and how to manage it. This research was conducted by researchers within a period of three months to review the effect of the Instagram application on the marketing cycle of PT. Alra Makmur Cahaya Selaras as well as monitoring several features that may affect the marketing process. The research method used is descriptive qualitative which will then be detailed in the results and discussion section of the research, namely regarding appropriate and effective marketing strategies in managing Instagram social media owned by PT. Alra Makmur Cahaya Harmonious.
Kuzey Orta Anadolu İskân Tarihinden Bir Kesit: Nahiyeden Köye Aştakul
Authors: ALANDAĞLI Murat
Published: December 2022

Aştakul, günümüz idarî taksimatına göre Çorum İline bağlı Ortaköy ilçesinin bir beldesi konumundadır. Çekerek ırmağının adeta ikiye böldüğü Geldiklan (Geldi-gelen) Ovasını takip eden Çorum ile Amasya arasındaki yol güzergâhında yer almaktadır. Hemen kuzeyinde tahminen 4, 5 km uzaklıktaki Ortaköy’deki Hitit dönemi ören yeri bölgenin oldukça köklü bir geçmişe dayandığının işaretidir. Ticaretin yoğun olduğu yol güzergâhı veya liman kenti değil de bir Orta Anadolu iskan merkezi olması bakımından benzeri pek çok bölge gibi tarihi tetik edilmemiştir. Tarihsel olarak XIII. yüzyıla kadar geriye giden köklü mazisi, Osmanlı İmparatorluğunun askerî, idarî, malî ve sosyo-kültürel gereksinimlere dayalı kayıt sistemi sayesinde nispeten aydınlatılabilir. Bu bakımdan XV. yüzyıl ile XVI. yüzyıl’a ait tahrir defterleri sayesinde çevresindeki köylerin merkezi konumundaki bir nahiye olarak karşımıza çıkmaktadır. Akabinde Celalî isyanlarının darmadağın ettiği bölgelerden biri haline geldiğini köy olarak XVII. yüzyıl kayıtlarında yer almasından anlaşılmaktadır. XVIII. yüzyılda siyasî, sosyal ve ticarî amaçlarla yapılmış kimi iskan faaliyetlerinin bir bakıma Aştakul’un yeniden toparlanmasına ve tekrar etki bir hüviyet kazanmasına yol açtığı görülmektedir. Nitekim Karadağ ve Alandağ eteklerini yurt edinen aşiretlerin Pazargahı olma vasfını bu sayede kazanmıştır. Fakat güneyde Amasya, Çorum ve Tokat işlek yoluna çok daha yakın Çay köy ile kuzeyinde çok daha köklü ve zengin bir iskan merkezi olma vasfına haiz Ortaköy Aştakul’a XVI. yüzyıl dünyasındaki görkemli günleri yaşatmaya izin vermez. Dolayısıyla giderek büyüyen iki merkezin arasında zengin tarihsel izlerin ışığında sıradan bir köy olarak uzun tarihsel süreçte yol almaya başlar. Çalışma Aştakul’un eldeki tarihsel veri dahilinde XV. yüzyıldan XX. yüzyıla kadar geçirmiş olduğu kendine has dün kurgusunu ortaya çıkarmayı ve bakımdan hem mikro boyutta uzun erimli çalışmalara örnek hem de Orta Anadolu tarihine dönük çalışmalara eklemlenmeyi amaç edinmektedir.
Polypropylene-based Multilayer Plastic Waste Utilization on Bitumen Modification for Hot-Mixed Asphalt Application: Preliminary Study
Authors: Nugraha Adam F. , Naindraputra Ardhito J. , Gaol Calvin S. A. L. , Ismojo Ismojo , Chalid M.
Published: December 2022

Plastic waste that has not been appropriately managed has caused concern for various stakeholders and has a negative impact on the environment. A way to minimize this issue is by promoting a circular economy through recycling. Despite this, many plastic wastes cannot be economically recycled; one of them is multilayer plastics due to the difficulty in sorting out the various types of materials contained in the layers. As an alternative, it may be possible to utilize multilayer plastic as a bitumen mixture; this method may avoid the separation process entirely. Bitumen is a component of asphalt, which is crucial to the construction of infrastructure. Plastics can potentially enhance the properties of modified bitumen, and they would assist in enhancing the quality of the asphalt. The aim of this study is to examine the impact of multilayer waste plastics on bitumen fabricated by the hot-mixing process. To enhance the compatibility between hydrophobic plastic and hydrophilic bitumen, lignin was used as a compatibilizer. The properties of bitumen with 3, 4, and 5 wt.% multilayer plastic and mixing times of 15, 30, and 45 minutes were evaluated. Accordingly, surface, chemical, thermal properties, and morphology were evaluated using sessile drop tests, Fourier Transform Infrared, thermogravimetry analysis, and scanning electron microscopy.
Application of DeLone and McLean Methods to Determine Supporting Factors for the Successful Implementation of Electronic Medical Records at Bali Mandara Eye Hospital
Authors: Dharma I Gusti Ngurah Aditya , Sukadarmika Gede , Pramaita Nyoman
Published: December 2022

Information technology in the health sector is currently an important factor in providing health services, especially hospitals. Bali Mandara Eye Hospital has implemented information technology in the registration process and bill issuance from 2015. Electronic Medical Record is a new application that will be implemented in 2021 at Bali Mandara Eye Hospital. Electronic Medical Record is a computerized system for recording patient health history. The implementation of electronic medical records at the Bali Mandara Eye Hospital for 1 year has many problems both in terms of regulations, systems and users. Therefore, the DeLone and McLean methods are used to determine the success rate of the implementation of electronic medical records. In this method, research is conducted on 6 variables, namely System Quality, Information Quality, Service Quality, Intention of Use, User Satisfaction and Net Benefits. From each variable, the researcher combines indicators from other researchers that are more appropriate for measuring electronic medical records. The results obtained that all statements submitted are valid. The success rate of electronic medical records at the Bali Mandara Eye Hospital was obtained at 3.22 or 80.50%. To be able to increase this value, it is recommended to improve the Information Quality, System Quality and User Satisfaction
The Effect of Hedonic Shopping Motivation, Shopping Lifestyle, and Fashion Involvement on Impulse Buying on Zalora Customers in Medan City
Authors: Edelia Annisa , Anggraini Tuti
Published: December 2022

The purpose of this study was to analyze the direct effect of Hedonic Shopping Motivation, Shopping Lifestyle, and Fashion Involvement on Impulse Buying. The population of this research is Zalora's customers in Medan city. With an unknown population, Bernoulli's formula is used and the number of samples is 60 respondents by purposive sampling. Data obtained by questionnaire google forms. The data analysis method used is associative statistical analysis and Partial Least Square (SEM-PLS) 3.0 analysis. Data collection techniques using a Google form questionnaire. The results show that the Hedonic Shopping Motivation variable has a significant effect on Impulse Buying, the Shopping Lifestyle variable has a significant effect on Impulse Buying and the Fashion Involvement variable has a significant effect on Impulse Buying.
Special Capacity Building Workshop in Bali in The Recovery of Tourism Sector in Bali During Covid-19 Pandemic
Authors: Purnawarman Andi , Anugrah Ridho
Published: December 2022

This study aims to find out and describe the collaboration between the United Nations World Tourism Organization (UNWTO) and Indonesia in supporting the development of the tourism sector in Bali during the Covid-19 pandemic. The research method uses the theory of international cooperation and tourism development with a descriptive type of research, secondary data, namely the data used obtained from the results of secondary data interpretation including articles, books and access to electronic media as well as qualitative data analysis techniques. The results of this study show that the cooperation of the United Nations World Tourism Organization (UNWTO) with Indonesia in supporting the development of the tourism sector in Bali during the Covid-19 pandemic includes conducting a special capacity building workshop in Bali on restarting international tourism in Bali and Bali will host the 2022 World Tourism Day activities with the theme "Rethinking Tourism".
Teacher Satisfaction, Self-Efficacy Affect on Teacher Performance: An Evidence from A Vocational School of Pharmaceutical Study Program East Borneo, Indonesia
Authors: Bustami M. Rajib , Azainil Azainil , Komariah Laili
Published: December 2022

This study aims to analyze the effect of teacher satisfaction, self-efficacy, and burnout on teacher performance in vocational schools in East Kalimantan. The method used in this research is quantitative. This study uses a questionnaire that has been validated and tested its reliability on 118 teachers. The data collection technique used a questionnaire to obtain data on teacher satisfaction, self-efficacy, and teacher performance. Data analysis with instrument validation of the three variables using Pearson correlation and reliability using Cronbach alpha, while for the approach using multiple linear regression analysis. The results showed that (1) teachers had a significant effect on teacher performance, meaning that higher teacher satisfaction resulted in an increase in teacher performance, (2) self-efficacy had a significant effect on teacher performance, (3) teacher goals and teacher self-efficacy jointly affected performance. teacher. significant on teacher performance. Results Based on the research, it can be concluded that the performance of teachers in the Pharmacy Study Program Vocational School can be improved through satisfaction and self-efficacy.
Influence of environmental factors on fish stocks in the Baltic Sea
Authors: Amosova V.  М. , Zezera A.  S. , Golubkova T. A.
Published: December 2022

The aim of this article: assess the impact of abiotic conditions on aquatic biological resources (sprat, herring, cod) of the Baltic Sea. The need for this study is due to the pronounced climate variability in the modern period. There is an increased role of the impact of environmental conditions on commercial fish species and, often, unfavorable for their spawning, survival of offspring, feeding, etc.   Methods used: carried out an integrated ecosystem analysis using the method of principal components in the R software environment. To detect statistically significant levels of changes in the time series of principal components, the STARS program, represented by an Excel add-in, was used. For the analysis of abiotic conditions, long-term series of air temperature, data from regular oceanological observations at a monitoring station were used. Since the stocks of commercial fish species in the Baltic Sea are transboundary, the values of their spawning biomass and biological parameters of populations were analyzed according to the data ofthe ICES Working Groups.   Novelty: this is the first time that such an analysis for a 30-year period adapted to the Russian water area in SD ICES 26 has been carried out.   Result: an integrated analysis of the abiotic and biotic components of the sea over the past three decades showed «mesoscale» shifts in 2002 and 2013. The direct and indirect impact of climate on the fish stocks of the Baltic Sea was an important unfavorable factor determining the current state, size and weight parameters, reproductive capacity and stocks dynamics. The most pronounced negative impact of environmental factors was noted for the stock of cod.   Practical significance: the results of the analysis carried out are necessary when predicting the catch of aquatic biological resources in the Baltic Sea for the short and long term, for making management decisions on the regulation of fishing in terms of understanding the risks in the current conditions of climate change.
Possible ways of solving the problem of providing new requirements for the consumption of fish products
Authors: Kolonchin K.  V. , Seregin S.  N. , Gorbunova M. A.
Published: December 2022

The purpose of the work is to determine the level of provision of the domestic market with fish products in order to meet the requirements for increasing the average per capita consumption of fish products by the population of the Russian Federation.   Materials and methods: official data published by the Federal State Statistics Service on the average per capita consumption of food products by the population, including fish products, were used in the work. The methods of logical and system analysis made it possible to identify promising sources of providing the domestic market of Russia with fish products.   The results of the study are to determine the sources of the resource base to increase the volume of production from aquatic biological resources in the domestic market. Proposals were made on the possible further development of the fishery complex of the Russian Federation, including measures of state support and regulation of the domestic market.   The practical significance lies in the possibility of using the results of the study in developing approaches to solving the task set by Rospotrebnadzor to increase the norms of per capita consumption of fish products by the population of the Russian Federation.
Oceanographic conditions within the main area of walleye pollock
Authors: Krovnin A. S. , Zuenko Yu. I. , Figurkin A. L. , Khen G. V. , Kivva K.  K. , Novikov Yu. V. , Tepnin O. B.
Published: December 2022

Purpose: to characterize oceanographic conditions and their variability at various time scales within the walleye pollock area, including all Far Eastern seas of Russia, the Chukchi Sea, and the South Kuril and East Kamchatka regions.

Methods: analysis of literary sources and data of expedition studies conducted by the Far Eastern branches of «VNIRO».

Novelty: for the first time, a generalization of current information on the oceanological conditions of walleye pollock habitat in the main areas of its reproduction, feeding and fishing was given.

Results: In the Bering Sea, three periods were identified during 1950–2020: cold period (1950–1976), moderate period (1977–2013) and warm period (2014–2020). Strong year-classes of walleye pollock were formed only over the moderate period. During the modern warming of the Bering Sea migrations of walleye pollock from the US EEZ into Russian waters occurs by one month earlier that favors the pollock fishery in the Navarin area and Gulf of Anadyr. The warming of Okhotsk Sea waters, combined with the tendency to reduction of its ice cover, favor expansion of the walleye pollock feeding area northward and westward. The warming of the Sea of Japan results in a depressive trend for all Japan Sea walleye pollock populations. At the same time, against the background of depression in modern (abnormally warm) conditions, the formation of single strong year-classes of any Japan Sea walleye pollock population is still possible.

Practical significance: the results of this work can be used to improve the methods of the medium-r ange and long-range forecasts of walleye pollock catch.