bluuebunny/crossref_metadata_2025 huggingface dataset:
In Vitro α-glucosidase Inhibition and Computational Studies of Kaempferol Derivatives from Dryopteris cycanida
Authors: Amin Surriya , Ullah Barkat , Ali Mumtaz , Khan Haroon , Rauf Abdur , Khan Sher A. , Sobarzo-Sánchez Eduardo
Published: January 2020

Background:

Dryopteris cycadina has diverse traditional uses in the treatment of various human
disorders which are supported by pharmacological studies. Similarly, the phytochemical studies of
this plant led to the isolation of numerous compounds.

Methodology:

The present study deals with α-glucosidase inhibition of various kaempferol derivates
including kaempferol-3, 4/-di-O-α- L-rhamnopyranoside 1, kaempferol-3, 5-di-O-α-L-rhamnoside 2 and
kaempferol-3,7-di-O-α- L-rhamnopyranoside 3.

Results:

The results showed marked concentration-dependent inhibition of the enzyme when assayed at
different concentrations and the IC50 values of compounds 1-3 were 137±9.01, 110±7.33, and 136±1.10
mM, respectively far better than standard compound, acarbose 290±0.54 mM. The computational studies
revealed strong docking scores of these compounds and augmented the in vitro assay.

Conclusion:

In conclusion, the isolated kaempferol derivatives 1-3 from D. cycadina exhibited potent α-
glucosidase inhibition.
Association Between Intra-Hospital Uncontrolled Glycemia and Health Outcomes in Patients with Diabetes: A Systematic Review of Observational Studies
Authors: Carvalho Renata Cunha , Nishi Fernanda Ayache , Ribeiro Tatiane Bomfim , França Gustavo Galvão , Aguiar Patricia Melo
Published: January 2020

Background:

Many people are still getting affected by uncontrolled glycemic events during
hospital admission, which encompasses hypoglycemia, hyperglycemia, and high glycemic variability.

Introduction:

Primary studies have shown an association of glycemic dysregulation with increased
length of hospital stay and mortality among overall patients, however, there is no systematic review of
current evidence on the association between uncontrolled in-hospital glycemia in patients with diabetes
and health outcomes. This study aimed to systematically review the current evidence on the association
between uncontrolled in-hospital glycemia in patients with diabetes and health outcomes.

Methods:

The association between glycemic dysregulation and health outcomes for inpatients with diabetes
was systematically reviewed. PubMed, Embase, and LILACS databases were searched. Two independent
reviewers were involved in each of the following steps: screening titles, abstracts, and fulltexts;
assessing the methodological quality; and extracting data from included reviews. Descriptive
analysis method was used.

Results:

Seven cohort studies were included, and only two had a prospective design, consisting of 7,174
hospitalized patients with diabetes. In-hospital occurrence of hypoglycemia, hyperglycemia, and glycemic
variability were assessed, and outcomes were mortality, infections, renal complications, and adverse
events. Among the exposure and outcomes, an association was observed between severe hypoglycemia
and mortality, hyperglycemia and infection, and hyperglycemia and adverse events.

Conclusion:

In-hospital uncontrolled glycemia in patients with diabetes is associated with poor health
outcomes. More studies should be conducted for proper investigation because diabetes is a complex
condition. Effects of glycemic dysregulation should be investigated on the basis of overall health of a
patient instead from only organ-target perspective, which makes the investigation difficult.
Context-Dependent Regulation of Nrf2/ARE Axis on Vascular Cell Function during Hyperglycemic Condition
Authors: Ramprasath Tharmarajan , Freddy Allen John , Velmurugan Ganesan , Tomar Dhanendra , Rekha Balakrishnan , Suvekbala Vemparthan , Ramasamy Subbiah
Published: January 2020

:

Diabetes mellitus is associated with an increased risk of micro and macrovascular complications. During hyperglycemic conditions, endothelial cells and vascular smooth muscle cells are exquisitely sensitive to high glucose. This high glucose-induced sustained reactive oxygen species production leads to redox imbalance, which is associated with endothelial dysfunction and vascular wall remodeling. Nrf2, a redox-regulated transcription factor plays a key role in the antioxidant response element (ARE)-mediated expression of antioxidant genes. Although accumulating data indicate the molecular mechanisms underpinning the Nrf2 regulated redox balance, understanding the influence of the Nrf2/ARE axis during hyperglycemic condition on vascular cells is paramount. This review focuses on the context-dependent role of Nrf2/ARE signaling on vascular endothelial and smooth muscle cell function during hyperglycemic conditions. This review also highlights improving the Nrf2 system in vascular tissues, which could be a potential therapeutic strategy for vascular dysfunction.
Inhibition by Substrates of a Coniferyl Alcohol Dehydrogenase Purified from Sugarcane Stalks
Authors: Alarcón Borja , de Armas Roberto , Vicente Carlos , Legaz María E.
Published: January 2020

Aims and Objectives:

This study aimed to characterize a coniferyl alcohol dehydrogenase from sugarcane stalks. Also, the purification of CAD from sugarcane stalks was also carried out to study kinetic properties and substrate specificity.

Background:

Sugarcane plants contain an alcohol dehydrogenase able to reduce both coniferyl and sinapyl aldehydes to their correspondent alcohols, although there are reasonable grounds for suspecting that these are two distinct enzymes.

Methods:

The enzyme, coniferyl alcohol dehydrogenase was 125-fold purified from sugarcane stalks. Its activity was estimated by HPLC by calculating the amount of product formed.

Results:

The enzyme showed an optimum pH value of 7.9, at an optimum temperature of 20-22°C and a molecular mass of 48 kDa. The Km value for coniferyl alcohol was 3.03 µM and the enzyme was shown to be inhibited by an excess of the substrate from 17 µM. This dehydrogenase showed a similar affinity to sinapyl alcohol (Km 1.78 µM).

Conclusions:

This paper provides circumstantial evidence about the existence of two different alcohol dehydrogenases, specific to each of the substrates.
Simultaneous Determination of Four Bioactive Flavonoids in Rat Plasma by UPLC-MS/MS and Comparative Pharmacokinetic Study after Oral Administration of Danyikangtai Powder and Three Compatibilities
Authors: Huang Yihe , Zhao Yanhui , Zhang Yumeng , Sun Lin , Zhao Chunjie , Zhang Xiangdong , Zhao Min
Published: January 2020

Background:

Danyikangtai powder, a Traditional Chinese Medicine (TCM) formula, shows
promise to become a novel drug candidate for the simultaneous treatment of chronic cholecystitis and
chronic pancreatitis. However, the pharmacokinetic behavior of Danyikangtai powder remains unclear.

Objective:

We investigated the comparative pharmacokinetics of four flavonoids in rats after oral administration
of Danyikangtai powder and three compatibilities.

Materials and Methods:

The comparative pharmacokinetics was studied by ultra-performance liquid
chromatography-tandem mass spectrometry (UPLC–MS/MS). Chromatographic separation was performed
on a Universil XB-C18 column with a gradient mobile phase containing 0.1% (v/v) aqueous
formic acid and acetonitrile. All analytes and internal standard were quantitated in the multiple reaction
monitoring modes with a positive electrospray ionization interface.

Results and Discussion:

Danyikangtai powder and Scutellariae radix have similar pharmacokinetic
behaviors in rats after oral administration. However, the elimination of four flavonoids in rats after oral
administration of Danyikangtai powder was accelerated, which was possibly related to the reduction of
the potential hepatotoxicity of Scutellariae radix. The varying degrees of change in pharmacokinetic
parameters after oral administration of different herb combinations suggested that herb–herb interactions
occurred in vivo.

Conclusions:

This study will be helpful to reveal the safety, rational and mechanism of Danyikangtai
powder formula compatibility, thereby providing pre-clinical research data for its new drug development
and guidance for its rational clinical application.
Computing Photonic Bandgap from Dispersion Relation for TM Mode Propagation Inside Metamaterial-Based 1D PhC
Authors: Deyasi Arpan , Dey Urmi , Das Sangita , De Soumita , Sarkar Angsuman
Published: January 2020

Aim:

Calculation of dispersion profile and photonic bandgap for negative refractive index based onedimensional
photonic crystal structure.

Objective:

Determine mathematically the variation of first and second photonic bandgaps under angular
incidence variation for the metamaterial-based 1D PhC structure for both TE and TM mode of
propagations.

Methods:

Two lowermost photonic bandgap widths of metamaterial-based one-dimensional photonic
crystal are analytically computed from the dispersion relation under the propagation of transverse
electromagnetic wave along the direction of confinement. Three practically realizable double negative
index materials are considered for computation of bandgaps, where air-gaps are considered along with
the artificially made materials as the composite grating structure. This is a combination of negative
positive indices materials, where incident angles are tailored within practical limit to calculate the variation
of bandgaps, which may be quasi or complete depending on the material composition and angle
of incidence.

Results:

Results are compared with that obtained for TE mode propagation, and are highly important
for design of the all-optical filter with DNG materials.
ÇOCUKLAR İÇİN AÇIK ALANDA OYUN TUTUM ÖLÇEĞİ: UYARLANMASI VE PSİKOMETRİK ÖZELLİKLERİ
Authors: Erdem Devrim
Published: January 2020

Bu araştırmanın amacı,
çocukların açık alanda oyun oynamaya yönelik tutumlarının belirlendiği yeni bir
ölçme aracı olan açık alanda oyuna yönelik tutum (AAOT) ölçeğini Türkçe’ye  uyarlamak ve psikometrik özelliklerini
incelemek olarak ortaya konmuştur. AAOT ölçeği, 9-13 yaş çocukların açık alanda
oynamaya yönelik tutumlarının değerlendirildiği 12 madde ve iki alt ölçekten
oluşan dörtlü Likert  tipinde bir
araçtır. Aracın Türk kültürüne uygunluğu ve dilsel eşdeğerliği
değerlendirildikten sonra uygulama yapılmıştır. Özgün örneklem grubunun yaş
özellikleri göz önüne alarak 9–13 yaş arası (4.–7. sınıf) 521 öğrenciye
uygulama yapılmıştır. Türkiye örnekleminde 12 maddelik AAOT ölçeği, toplam
varyansın %54.46’sını açıklayan üç faktörlü bir yapı göstermiştir. Bu üç
faktörlü modelin gerçek verilere uyumu doğrulayıcı faktör analizi ile
değerlendirilmiştir. Bulgular incelendiğinde üç faktörlü yapının model uyum
indekslerinin iyi düzeyde olduğu ortaya çıkmıştır. Açık alanda oyunun
faydalarına ilişkin alt ölçek dört maddeden (α=.70), açık alanda
yapılandırılmamış oyuna ilişkin alt ölçek üç maddeden (α=.67) ve açık alanda
oyun oynamaya yönelik korkular alt ölçeği beş maddeden (α=.81) oluşmaktadır.
Her bir alt ölçekteki madde sayılarının azlığı dikkate alındığında iç tutarlık
katsayıları kabul edilebilir düzeydedir. Sonuç olarak, AAOT ölçeğinin Türkiye
örnekleminde kullanılabilecek geçerli ve güvenilir bir araç olduğu
belirlenmiştir.
Other people’s data: humanities edition
Authors: Allison Sarah
Published: January 2020

Every project that uses numbers to make sense of literature seems to teach us again that in digital analysis we create more data than we can ever fully use and therefore understand. And yet, with each new project we produce more. In the Community Resource Guide to Digital Humanities Curation, Julia Flanders and Trevor Muñoz define research data as the “raw and abstracted material created as part of research processes and which may be used again as the input to further research.” Computational analysis of large corpora is a time- consuming process, and a lot of analysis ends up on the cutting room floor (or on the blog, or in a footnote or an appendix). We need to make better use of that discarded data—the detritus other people shed on the way to an answer. Think of it as data recycling to combat data waste.
Do we know what we are doing?
Authors: Piper Andrew
Published: January 2020

In November 2012, the newly created Open Science Collaboration published a brief article announcing a multi-year effort to “estimate the reproducibility of psychological science.” The collaboration was directed by Brian Nosek of the University of Virginia and would eventually involve over 250 co-authors. According to the collaboration, reproducibility was one of, if not the single most defining feature of the social endeavor known as “science.” “Other types of belief,” the authors write, “depend on the authority and motivations of the source; beliefs in science do not.” The ability to reproduce scientific results across time and space – the ability to have results be independent of the individuals involved – is what the authors argued makes science science. And yet the eventual findings of the reproducibility project showed a remarkable reproductive failure. Over half of all studies failed to indicate similar effects upon replication. The very value upon which science was supposed to be founded appeared to be an exception rather than a norm.
Safety and effectiveness of ataluren: comparison of results from the STRIDE Registry and CINRG DMD Natural History Study
Authors: Mercuri Eugenio , Muntoni Francesco , Osorio Andrés Nascimento , Tulinius Már , Buccella Filippo , Morgenroth Lauren P , Gordish-Dressman Heather , Jiang Joel , Trifillis Panayiota , Zhu Jin , Kristensen Allan , Santos Claudio L , Henricson Erik K , McDonald Craig M , Desguerre Isabelle ,   on behalf of the STRIDE,   CINRG Duchenne Natural History Investigators
Published: January 2020

Aim:
Strategic Targeting of Registries and International Database of Excellence (STRIDE) is an ongoing, multicenter registry providing real-world evidence regarding ataluren use in patients with nonsense mutation Duchenne muscular dystrophy (nmDMD). We examined the effectiveness of ataluren + standard of care (SoC) in the registry versus SoC alone in the Cooperative International Neuromuscular Research Group (CINRG) Duchenne Natural History Study (DNHS), DMD genotype–phenotype/–ataluren benefit correlations and ataluren safety.
Patients & methods:
Propensity score matching was performed to identify STRIDE and CINRG DNHS patients who were comparable in established disease progression predictors (registry cut-off date, 9 July 2018).
Results & conclusion:
Kaplan–Meier analyses demonstrated that ataluren + SoC significantly delayed age at loss of ambulation and age at worsening performance in timed function tests versus SoC alone (p ≤ 0.05). There were no DMD genotype–phenotype/ataluren benefit correlations. Ataluren was well tolerated. These results indicate that ataluren + SoC delays functional milestones of DMD progression in patients with nmDMD in routine clinical practice.
ClinicalTrials.gov identifier:
NCT02369731.

ClinicalTrials.gov identifier:
NCT02369731.
Nuevo registro de parto séxtuple de jutía conga Capromys pilorides (RODENTIA: CAPROMYIDAE) en Cuba
Authors: Amaro-Valdés Seriocha , Garcés-Ramírez Edilberto M. , Cordero-Arcia Milagros , Hernández-Pérez Ernesto
Published: January 2020

Resumen La jutía conga, Capromys pilorides, es el mayor de los roedores caprómidos endémicos de las Antillas, distribuido a lo largo del archipiélago cubano. Es una de las dos especies de jutías cubanas politípicas, con cuatro subespecies vivientes reconocidas, y no está amenazada de extinción. Esta jutía es la especie con más información disponible sobre su biología, tanto en la naturaleza como en cautiverio, en particular sobre su reproducción. En este trabajo registramos un nuevo parto séxtuple de una jutía conga ocurrido en cautiverio, lo que confirma esta cifra como el tamaño máximo de la camada alcanzado por la especie. En esta nota se ofrecen algunos aspectos del parto y la dieta suministrada a las crías en cautiverio, así como las causas probables de las diferencias entre el número de embriones y el tamaño de la camada de las jutías cubanas en vida libre y en cautiverio. También se recomienda la cría planificada de esta especie en cautiverio como una alternativa importante para obtener información sobre su biología reproductiva, etología, y en favor de la disminución necesaria de la caza de sus poblaciones silvestres.Palabras clave: Antillas, Capromyidae, Capromys pilorides, reproducción, Rodentia, tamaño de camada. Abstract The Conga or Desmarest's hutia, Capromys pilorides, is the largest endemic capromyid rodent in the West Indies, distributed throughout the Cuban archipelago. With four recognized subspecies, the Conga is one of the two Cuban polytypical species of hutias and is not threatened. Conga hutia is the best know biologically, both in nature and captivity, particularly regarding its reproduction. We are herein recording a new six-brood captivity parturition of the Conga hutia confirming a maximum litter size for the species. Some aspects of the parturition and new-born diet provided are mentioned, as well as the probable causes of the differences between number of the embryos and litter size in Cuban hutias in nature and captivity. A captive breeding plan for the Conga hutia is recommended as an important alternative to obtain information on its ethology, and reproductive biology, favoring the necessary decrease in the hunting of its natural populations.Key words: Capromyidae, Capromys pilorides, litter size, reproduction, Rodentia, West Indies.
Cronología histórica de la quiropterología en Nicaragua
Authors: Medina-Fitoria Arnulfo , Martínez-Fonseca José G.
Published: January 2020

ResumenEn este artículo describimos cronológicamente 182 años de investigación chiropterológica que atribuyen 110 especies en Nicaragua; desde la primeracolecta registrada en 1837 hasta la última publicación hecha en 2019. Estos trabajos fueron hechos en su totalidad por extranjeros hasta finalesdel siglo pasado, con una importante participación de investigadores nacionales a partir del siglo XXI. Determinamos tres épocas principales de exploración y cuyo auge ha dependido de las situaciones sociopolíticas del país. La primera seextendió de finales del siglo XIX hasta principios del siglo XX, con un segundo periodo durante las décadas de 1960 y 1970 y un tercer período que transcurre a lo largo del siglo XXI. En total recopilamos y analizamos 93 publicaciones científicas, las cuales datamos y ordenamos según su fecha de publicación. El recuento histórico reconoce a naturalistas y científicos nacionales y extranjeros que han contribuido al conocimiento de los murciélagos del país, donde se resaltan algunas de las obras más significativas para el desarrollo de la mastozoología en Nicaragua.Palabras clave: Especies, localidades, murciélagos, publicaciones. AbstractWe chronologically describe 182 years of chiropterological research, attributing 110 species in Nicaragua; from the first collection recorded in 1837 untilthe last publication made  in 2019; these works were made entirely by foreigners until the end of the last century, with an important participation of nationalresearchers from the 21st century. We determined three main periods of exploration and whose duration has depended on the socio-political situationsof the country. The first extended from the late nineteenth century to the early twentieth century, with a second period during the 1960s and 1970s; and athird period that runs throughout the 21st century. In total we collect and analyze 93 reports, which we date and order according to their publication date.The historical account recognizes national and foreign naturalists and scientists who have contributed to the knowledge of the country’s bats, highlighting some of the most significant works.Key words: Bats, localities, publications, species.
Uso de la mastofauna silvestre en la comunidad cafetalera de Cumbres de Huicicila, Compostela, Nayarit, México
Authors: Medina-Gutiérrez Fátima Carolina , Ramírez-Silva Juan Pablo
Published: January 2020

ResumenEl objetivo del presente trabajo fue analizar la percepción y usos de los mamíferos silvestres en un área cafetalera de la comunidad Cumbres de Huicicila, municipio de Compostela, Nayarit. Se utilizaron técnicas etnozoológicas tales como aplicación de encuesta sobre el usos y costumbres que tienen en relación con los mamíferos. Adicionalmente, se usaron cámaras-trampa con un esfuerzo de muestreo de 1,260 días/trampas. En total se obtuvieron 531 videos y 373 registros válidos de mamíferos silvestres de 10 especies pertenecientes a cinco órdenes y siete familias, tres de ellas enlistadas en la NOM-059-SEMARNAT-2010 y la lista roja de la UICN (Panthera onca, Leopardus pardalis y Herpailurus yagouaroundi). A través de las herramientas etnozoológicas se identificaron 15 especies de mamíferos y cinco órdenes. Las personas de la comunidad afirmaron darle algún tipo de uso a los mamíferos que conocen, entre los que destacan el alimenticio, medicinal, tráfico ilegal (venta de especies), cacería e inclusive se mencionaron algunos conflictos de relación depredador-humano. A pesar de lo mencionado, la participación de la comunidad fue positiva. Trabajos de este tipo pueden favorecer la sensibilización hacia la vida silvestre y así, la ejecución de programas de manejo, uso y conservación de mamíferos podría tener éxito y ayudar a la subsistencia de la comunidad.Palabras clave: Cafetales, etnomastozoología, jaguar, mesomamíferos, uso de fauna silvestre.AbstractIn this paper we analyzed the perception and uses of the wild mammals by the population that inhabited in Cumbres de Huicicila community, municipality of Compostela, Nayarit, the information was complemented by the use of camera traps, from which we obtained 531 videos with 373 valid records of wild mammals, with 1,260 days/traps sampling effort . We recorded 10 species belonging to five orders and seven families, three of such (Panthera onca, Leopardus pardalis and Herpailurus yagouaroundi) are listed in NOM-059-2010 and the IUCN red list. The inhabitants of the Cumbres de Huicicila community identify 20 species of mammals, including the 10 species registered by the camera traps, the people of the community know the mammals and are used, they mentioned as food, medicine, illegal trafficking, hunting for leisure and ornaments and even some predatory-human relationship conflicts.Despite them, community participation was positive, we believe that this works can aid to create the awareness of wildlife and thus, the implementation of mammalian management, use and conservation programs could be successful and help the community to increase quality live.Key words: Coffee plantations, ethnozoology, jaguar, medium-sized mammals, use of wildlife.
Creating opportunities to discuss the nature of Japanese science communication
Authors: Kudo Mitsuru , Wood Matthew
Published: January 2020

Build SciComm, an international symposium on strategies for fostering science communication in Japan held at the University of Tsukuba in November 2019, brought together academics and practitioners to discuss issues faced by the field in Japan and vision for future direction. Informally, the symposium was well received and generally considered to be a useful and stimulating event. We discuss issues to be considered for future incarnations and explain why this symposium provides an important forum for inclusive discussions on fundamental questions about the nature of science communication in Japan.
Конусы и многогранники обобщенных метрик
Authors: Деза Елена Ивановна
Published: January 2020

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Факторно делимые группы и группы без кручения, соответствующие конечным абелевым группам
Authors: Компанцева Екатерина Игоревна , Фомин Александр Александрович
Published: January 2020

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О почти локально разрешимых алгебрах Ли с нулевым радикалом Джекобсона и локально нильпотентном радикале для алгебр Ли
Authors: Пихтилькова Ольга Александровна , Мещерина Елена Владимировна , Горелик Анна Александровна
Published: January 2020

В статье доказывается аналог теоремы Ф. Кубо [1] для почти локально разрешимых алгебр Ли с нулевым радикалом Джекобсона. Первый раздел направлен на выяснение некоторых аспектов гомологического описания радикала Джекобсона. Доказана теорема, обобщающая теорему Е. Маршалла на случай почти локально разрешимых алгебр Ли, следствием которой и является аналог теоремы Кубо. Во втором разделе исследуются некоторые свойства локально нильпотентного радикала алгебры Ли. Рассматриваются примитивные алгебры Ли. Приведены примеры, показывающие, что бесконечномерные коммутативные алгебры Ли являются примитивными над любыми полями; конечномерная абелева алгебра, размерности больше 1, над алгебраически замкнутым полем не является примитивной; пример неартиновой некоммутативной алгебры Ли являющейся примитивной. Показано, что для специальных алгебр Ли над полем характеристики нуль PI-неприводимо представленный радикал совпадает с локально нильпотентным. Приведен пример алгебры Ли, локально нильпотентный радикал которой не является ни локально нильпотентным, ни локально разрешимым. Даются достаточные условия примитивности алгебры Ли, приводятся примеры примитивных алгебр Ли и алгебры Ли не являющейся примитивной.
Приближение квадратичных алгебраических решёток целочисленными решётками
Authors: Кормачева Антонина Николаевна
Published: January 2020

Данная работа посвящена вопросам приближения квадратичной алгебраической решётки целочисленной решёткой. В ней вычисляются расстояния между квадратичной алгебраической решёткой и целочисленной решёткой, когда они заданы числителем и знаменателем подходящей дроби к корню квадратному из простого числа ???? вида ???? = 2 или ???? = 4???? + 3.Результаты данной работы позволяют изучать вопросы о наилучших приближенияхквадратичных алгебраических решёток целочисленными решётками.
Основы формирования у учащихся исследовательских умений и ИКТ-компетенций при обучении решению задач с использованием компьютера
Authors: Абдуразаков Магомед Мусаевич , Гаджиев Джаваншир Джебраил , Гусева Наталья Валерьевна , Токмазов Георгий Васильевич
Published: January 2020

В исследовании рассматривается модель создания серии обучающих заданий, построенной с опорой на представления о трехкомпонентной структуре умственных действий (О-ориентировка, И-исполнение, К-контроль). С помощью задач динамического характера, ориентированных на управление учебно-познавательной деятельностью обучающихся, в работе раскрывается один из возможных подходов к совместному изучению формул полной вероятности и Байеса. Отмечается, что для эффективности управления учебно-познавательной деятельностью обучающихся, осуществляется пооперационная обратная связь, переходящая в промежуточную обратную связь и связь по конечному результату.В статье подчеркивается, что оптимальность процесса формирования элементов исследовательской деятельности осуществляется за счет повышения эффективности усвоения его по времени. Последнее достигается за счет приемов совместного усвоения обучающимися учебного материала, связанного с усвоением, например, формул полной вероятности и Байеса.В этом же ракурсе отмечается, что целесообразно использовать этапы информационной технологии решении задач, а использование ИКТ как процесс формирования инструментария в жизни и ИКТ-компетенций для профессиональной ориентации выпускника школы.В статье особо подчеркивается необходимость формирования ИКТ-компетенций учителя как требование федерального государственного образовательного стандарта в условиях в информационной образовательной среды, определены принципы построения методиче ской системы формирования ИКТ-компетенций в рамках педагогических вузов через решения задач с использованием компьютерных технологий.
Об оценках сверху числа минимальных полиномов с малой производной в корне
Authors: Васильев Денис Владимирович , Кудин Алексей Сергеевич
Published: January 2020

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(MULTI)LETRAMENTO DIGITAL: O SNAPCHAT NO ÂMBITO ESCOLAR
Authors: Andrade Alan Victor , Dalinghaus Ione Vier
Published: January 2020

A proposta deste trabalho é demonstrar como o uso de novas tecnologias no âmbito de sala de aula pode auxiliar na aprendizagem do aluno, tornando as atividades mais relevantes e significativas. A pesquisa teve como objeto de estudo uma aula realizada por pibidianos da Universidade Federal do Mato Grosso do Sul, Campus Aquidauana, no ensino Médio de uma escola pública Estadual de Anastácio, MS. A temática escolhida pelo grupo foi “Setembro Amarelo”, uma campanha que tem como foco conscientizar os alunos sobre a prática do suicídio. Para despertar o interesse dos alunos, tanto para o tema, muito relevante devido ao alto índice de suicídios de jovens nesta cidade, quanto para a participação no PIBID, foi elaborada uma aula com o uso do aplicativo Snapchat. Por meio de teorias que defendem a necessidade de práticas multiletradas, multissemióticas e críticas em sala de aula e ancorados em estudos de autores como Monte Mór (2010), Rojo (2012, 2013), Takaki (2012) e outros estudiosos da Pedagogia dos Multiletramentos e Letramento Crítico, fez-se uma adaptação das mídias digitais com o conteúdo ministrado. Obteve-se um retorno bastante satisfatório nas atividades realizadas na perspectiva dos multiletramentos, confirmando-se o êxito não apenas no ensino-aprendizagem dos escolares, mas também, na formação dos acadêmicos.
The effect of financial performance and corporate governance to stock price in non-bank financial industry
Authors: Karamoy Herman , Tulung Joy Elly
Published: January 2020

Indonesia’s financial sector is highly dominated by the banking industry than the non-bank. It controlled almost 74% of Indonesia’s financial assets in 2014. After post-crisis restructuration, the banking sector has become stronger, with a higher capital adequacy ratio and profitability. While, the non-bank financial industry is expected to solve the problems in the Indonesian economy, as well as becoming one of the long-term economic instruments. The purpose of this study is to test and analyse the effect of financial performance and the implementation of corporate governance on the non-bank financial industry stock prices on the Indonesia Stock Exchange in 2012-1016. The research population includes the non-bank financial industry listed in IDX, as many as 37 companies. This study found the probability, managerial ownership, institutional ownership and the composition of the independent commissioner partially and simultaneously does not significantly influence the stock price of the non-bank financial industry.
Larrey diaphragmatic hernia in an adult
Authors: Stanojevic Goran , Nestorovic Milica , Brankovic Branko , Bogdanovic Aleksandar , Radojkovic Milan , Ignjatovic Nebojsa
Published: January 2020

Introduction. Larrey hernia is a very rare type of the left sided parasternal congenital hernia with the incidence of 1?3% of all anterior diaphragmatic hernias. Case report. The paper describes Larrey congenital diaphragmatic hernia in an adult female patient, aged 70 years. Seventeen years earlier, the patient had had problems with intermittent left side chest pain, hypertension, dyspnea, shortness of breath, fatigue, and abdominal discomfort. She had no past surgical history, and no traumatic rupture of the diaphragm. An open surgical repair was conducted, reducing the herniated organs back into the abdominal cavity, and closing the diaphragmatic defect, repaired with a non-absorbable suture. During the immediate postoperative period, as well as six months later, the patient had a remarkable postoperative recovery. Conclusion. Larrey hernia represents an extremely rare kind of the anterior diaphragm hernias, which can be symptomatically manifested in older persons over 65 years of age. The treatment in the cases of asymptomatic and symptomatic Larrey hernias is a surgical intervention.
Different solvent extract of Toona sinensis wood by FT-IR and GC-MS
Authors: Yang Yafeng , Ma Yongtao , Zhang Jiangtao , Li Cheng
Published: January 2020

Forest biomass energy material is the natural material for human survival. Wood is the main material for human development. In order to save energy, the active chemical components in wood are extracted by modern equipment and applied to biomedicine, high-grade cosmetics, precious spices and other products to promote the high attachment of wood processing industry and Value-added development. The FT-IR was used to analyze and compare the extracts of Toona sinensis with ethanol, methanol and benzyl/ethanol in different solvents. Because of benzene ring of lignan suffered the most destruction from benzene/ethanol extractives, the FT-IR results showed that the absorbance of each peak was maximal at the benzene/ethanol extractives and minimal at the methanol extractives. In the gas chromatography-mass spectrometer (GC-MS) test, the ethanol extractives of Toona sinensis wood had a main retention time between 10-20 minute, which accounts for 38.44% of the total relative content; methanol extractives had a main retention time between 5-15 minute, which accounts for 41.22% of the total relative content; the benzene/ethanol extractives between 10-20 minute accounted for 44.46% of the total relative content. The chemical composition and retention time of the three solvent extracts are different. The measurement and analysis of the experimental data opened up a new way for the development and utilization of woody plant energy.
Medical molecules of waste Chinese buckeye seed from pharmacy
Authors: Li Yiyang , Bi Huitao , Zheng Dongfang , Zhao Yong , Wang Yaoming , Gu Haiping , Chen Xiangmeng , Liu Zhenling
Published: January 2020

Fourier transform infrared (FT-IR) spectroscopy and gas chromatography-mass spectrometer (GC-MS) were used to analyze organic solvent extracts of Populus tomentosa Carriere, the results show that the Chinese Buckeye Seed is mainly healthy and rich in Chinese Buckeye Seed extracts, The main representative of the active ingredient are Furfural, Isosorbide Dinitrate, Catechol, 1,2-Benzenediol, 4-methyl-, 3-Amino-s-triazole, 2,3-Quinoxalinedione, 1,4-dihydro-, Docosanoic acid, Medetomidine. Chinese Buckeye Seed extract contains a large amount of biologically active ingredients, including acids, phenols, alcohols, ketones and ethers, not only in the fields of bioenergy, biomedicine, cosmetics, skin care and fragrance, but also potential application prospects, Chinese Buckeye Seed?s chemical composition research provides a scientific basis for the development and utilization of this plant.
Fourier transform infrared and gas cromatography-mass extracts from Euscaphis japonica bark
Authors: Wei Zihan , Sun Zhiyong , Wang Yaoming , Dong Shuaiwei , Lv Chunxia , Wang Ting , Yan Shuangxi , Wang Chao
Published: January 2020

Due to the lack of studies on the chemical constituents of Euscaphis japonica bark, infrared spectroscopy and gas chromatography-mass spectrometer (GC-MS) techniques were used to analyze the ethanol, phenyl alcohol and methanol extracts from Euscaphis japonica bark, laying a foundation for the efficient utilization of Euscaphis japonica bark. Through experimental verification, different extracts of Euscaphis japonica bark can yield different chemical substances: Stigmast-4-en- 3-one, (1R,8a alpha)-1,4a beta-dimethyl -7 beta -(1-hydroxy-1-methylethyl)decalin-1 alpha-ol, lactose, Vitamin E, 9,12-octadecadienoic acid, n-hexadecanoic acid, Arsenous acid Tris(trimethylsilyl)ester 4-hydroxy-3-methoxycianamylic alcohol, etc. It was determined that most of the chemicals in Euscaphis japonica bark are soluble in ethanol reagents. According to the relevant mass spectrometry data, Euscaphis japonica bark contains useful pharmaceutical ingredients and chemical raw materials and has broad development prospects.
Institutional Investor Attention and Firm Disclosure
Authors: Abramova Inna , Core John E. , Sutherland Andrew
Published: January 2020

We study how short-term changes in institutional owner attention affect managers' disclosure choices. Holding institutional ownership constant and controlling for industry-quarter effects, we find that managers respond to attention by increasing the number of forecasts and 8-K filings. Rather than alter the decision of whether to forecast or to provide more informative disclosures, attention causes minor disclosure adjustments. This variation in disclosure is primarily driven by passive investors. Although attention explains significant variation in the quantity of disclosure, we find little change in abnormal volume and volatility, the bid-ask spread, or depth. Overall, our evidence suggests that management responds to temporary institutional investor attention by making disclosures that have little effect on information quality or liquidity.

JEL Classifications: G23; G32; G34; G12; G14.
Homozygous Hypomorphic HNF1A Alleles Are a Novel Cause of Young-Onset Diabetes and Result in Sulfonylurea-Sensitive Diabetes
Authors: Misra Shivani , Hassanali Neelam , Bennett Amanda J. , Juszczak Agata , Caswell Richard , Colclough Kevin , Valabhji Jonathan , Ellard Sian , Oliver Nicholas S. , Gloyn Anna L.
Published: January 2020

OBJECTIVE

Heterozygous loss-of-function mutations in HNF1A cause maturity-onset diabetes of the young (MODY). Affected individuals can be treated with low-dose sulfonylureas. Individuals with homozygous HNF1A mutations causing MODY have not been reported.

RESEARCH DESIGN AND METHODS

We phenotyped a kindred with young-onset diabetes and performed molecular genetic testing, a mixed meal tolerance test, a sulfonylurea challenge, and in vitro assays to assess variant protein function.

RESULTS

A homozygous HNF1A variant (p.A251T) was identified in three insulin-treated family members diagnosed with diabetes before 20 years of age. Those with the homozygous variant had low hs-CRP levels (0.2–0.8 mg/L), and those tested demonstrated sensitivity to sulfonylurea given at a low dose, completely transitioning off insulin. In silico modeling predicted a variant of unknown significance; however, in vitro studies supported a modest reduction in transactivation potential (79% of that for the wild type; P < 0.05) in the absence of endogenous HNF1A.

CONCLUSIONS

Homozygous hypomorphic HNF1A variants are a cause of HNF1A-MODY. We thus expand the allelic spectrum of variants in dominant genes causing diabetes.
Unlocking the Potential of Electronic Health Records for Health Research
Authors: Lee Seungwon , Xu Yuan , D'Souza Adam G , Martin Elliot A , Doktorchik Chelsea , Zhang Zilong , Quan Hude
Published: January 2020

Electronic health records (EHRs), originally designed to facilitate health care delivery, are becoming a valuable data source for health research. EHR systems have two components: the front end, where the data is entered by healthcare workers including physicians and nurses, and the back-end electronic data warehouse where the data is stored in a relational database. EHR data elements can be of many types, which can be categorized as structured, unstructured free-text, and imaging data. The Sunrise Clinical Manager (SCM) EHR is one example of an inpatient EHR system, which covers the city of Calgary (Alberta, Canada). This system, under the management of Alberta Health Services, is now being explored for research use. The purpose of the present paper is to describe the SCM EHR for research purposes, showing how this generalizes to EHRs in general. We further discuss advantages, challenges (e.g. potential bias and data quality issues), and analytical capacities and requirements associated with using EHRs.
De viva voz: estudio fenomenológico con agresores primarios de violencia de pareja o conyugal
Authors: González Jaimes Elvira Ivone , Oviedo Zuñiga Ana María , Miguel Silva María Guadalupe , Mendieta Vargas Alejandro
Published: January 2020

La violencia de género en México es alta. De acuerdo con el Instituto Nacional de Estadística y Geografía [Inegi] (22 de noviembre del 2018), 19.1 millones de mujeres adultas mayores de 15 años han enfrentado violencia conyugal o de pareja. La agresión se genera frecuentemente en escenarios privados: por lo vulnerable que se encuentra la mujer ahí. A sabiendas de que el evento de intimidad y agresión es difícil de investigar, en este estudio se entrevistó a 32 participantes (agresores primarios de la pareja) que requerían ser evaluados psicológicamente en los Centros de Atención de la Casa de la Mujer de los municipios de Atizapán y Ecatepec, Estado de México, México. El objetivo fue conocer las causas a través de la propia voz de los agresores primarios, y así obtener una visión objetiva y amplia de los disparadores que producen el fenómeno social de violencia conyugal. Para ello se recurrió a dos tipos de entrevista. La primera fue cerrada y bajo la guía del Manual de Diagnóstico y Estadístico de Trastornos Mentales [DSM-5, por sus siglas en inglés] (American Psychiatric Association [APA], 2013), con el diagnóstico “Relación conflictiva con el cónyuge o la pareja”; y la segunda fue una entrevista semiestructurada para maltratadores de género. El método utilizado fue el análisis de datos de tipo mixto (cuantitativo y cualitativo) para triangular información y entender el qué y el cómo de la agresión de género. Como parte de los resultados, se encontró que la concepción devaluada de la mujer se ve reflejada en el rechazo constante a las conductas positivas de la pareja (84 %), las conductas de la pareja para obtener un valor y ejercer derechos desencadenan en conflictos difíciles de resolver (72 %), porque el agresor está en la idea de conservar su lugar jerárquico de poder y de protección social al ser débil (física y mentalmente), por lo que reconoce la asunción de responsabilidad (66 %). Esta ambivalencia entre deseo y acción, “querer y no poder”, produce tristeza, apatía o rabia crónicas hacia la pareja. Por lo que se recomienda que el agresor primario de la pareja ingrese a pláticas o psicoterapia, donde obtenga justicia terapéutica para que reaprenda cómo relacionarse con su pareja o cónyuge y finalmente cambie sus ideas y rompa con el estereotipo social de machismo.
KOMUNITAS NEMATODA PADA BEBERAPA LOKASI PENANAMAN UBI KAYU DI PROVINSI LAMPUNG
Authors: Prayugo Dwi , Swibawa I G , Solikhin Solikhin , Susilo F X
Published: January 2020

Penelitian ini bertujuan untuk mempelajari keragaman dan kelimpahan komunitas nematoda yang berasosiasi dengan pertanaman ubi kayu (Manihot esculenta Crantz) di Provinsi Lampung. Pengambilan sampel menggunakan metode survai dilakukan di tiga sentra pertanaman ubi kayu yang terletak di Lampung Selatan, Lampung Tengah, dan Lampung Timur. Proses laboratorium dilakukan di Laboratorium Ilmu Hama Tumbuhan Fakultas Pertanian Universitas Lampung. Penelitian dilaksanakan dari bulan Oktober 2017 sampai dengan Februari 2018. Variabel komunitas nematoda yang diamati meliputi Prominance Value (PV) genus, keragaman nematoda yang diukur dengan jumlah genus dan indeks keragaman Shannon dan indeks karagaman Simpsons, kelimpahan seluruh nematoda dan kelimpahan genus nematoda parasit tumbuhan yang dominan.  Data keragaman dan kelimpahan nematoda dianalisis ragam dan nilai tengah diuji dengan uji Beda Nyata Terkecil (BNT) pada taraf nyata 5%.  Hasil penelitian menunjukkan pada pertanaman ubi kayu di Lampung ditemukan 29 genus nematoda yang terdiri dari 17 genus nematoda parasit tumbuhan dan 12 genus nematoda hidup bebas; genus nematoda parasit tumbuhan yang dominan yaitu Helicotylenchus, Pratylenchus, Meloidogyne, Apelenchus, dan Xiphinema.  pada setiap lokasi penanaman ubi kayu ditemukan 11 - 17 genus, Indeks Shannon 2,1- 2,5, dan Indeks Shimpson’s 0,8 - 0,9.   2). Kelimpahan seluruh nematoda yang ditemukan tiap kabupaten berkisar antara 194,3 - 875,0 individu/300cc tanah, nematoda parasit tumbuhan 169,1-746,6 individu/300cc tahah, nematoda hidup bebas 25,2 - 128,4 individu/300cc tanah.  3).  Lokasi penanaman ubi kayu mempengaruhi kelimpahan dan keragaman nematoda.
PENGARUH ARAH GULUDAN DAN PEMBERIAN PUPUK ORGANONITROFOS TERHADAP RESPIRASI DAN BIOMASSA KARBON MIKROORGANISME (C-MIK) TANAH SELAMA FASE VEGETATIFTANAMAN UBI KAYU (Manihot esculenta Crantz)
Authors: Saragih Sahel Renegade , Dermiyati Dermiyati , Niswati Ainin , Banuwa Irwan Sukri
Published: January 2020

Respirasi dan biomassa karbon mikroorganisme (C-mik) tanah merupakan sifat biologi yang dapat dijadikan sebagai indikator kesuburan tanah.  Perlakuan guludan dan pemberian pupuk Organonitrofos yang diberikan ke tanah akan mempengaruhi respirasi dan C-mik tanah.  Penelitian ini bertujuan untuk mengetahui pengaruh perlakuan guludan, pemberian pupuk Organonitrofos, dan interaksi keduanya terhadap respirasi tanah dan C-mik tanah.  Penelitian ini dilaksanakan selama fase vegetatif tanaman ubi kayu, yaitu Desember 2017 s.d. Mei 2018 di Laboratorium Lapang Terpadu, Fakultas Pertanian, Universitas Lampung,menggunakan Rancangan Acak Kelompok Lengkap (RAKL) yang disusun secara faktorial dengan dua faktor.  Faktorpertamameliputiperlakuan guludan, yaitu guludan searah lereng (G1) dan guludan memotong lereng (G2).  Faktorkeduameliputi pemberian pupuk Organonitrofos, yaitu Organonitrofos 0 t ha-1 (P0) dan Orgononitrofos 20 t ha-1 (P1).  Data yang diperoleh diujihomogenitas ragamnya dengan uji Bartlett dan aditivitasnya dengan uji Tukey.Data dianalisis dengan analisis ragam dan dilanjutkan dengan uji BNT pada taraf 5%.Hubungan antara suhu, C-organik, N-total, dan pH tanah dengan respirasidan C-mik tanah diuji dengan uji korelasi.  Hasil penelitian menunjukkan bahwa perlakuan guludan tidak berpengaruh nyata terhadap respirasi tanah pada pengamatan 0, 30, 60, 90, 120, dan 150 HST, namun berpengaruh nyata terhadap C-mik tanah pada pengamatan 120 HST.  Pemberian pupuk Organonitrofos berpengaruh nyata terhadap respirasi tanah pada pengamatan 150 HST, tetapi tidak berpengaruh nyata terhadap C-mik tanah.  Terdapat interaksi antara perlakuan guludan dan pemberian pupuk Organonitrofos terhadap C-mik tanah pada pengamatan 90HST, tetapi tidak berpengaruh nyata terhadap respirasi tanah.
PENGARUH KOMBINASI PUPUK ORGANONITROFOS DAN PUPUK ANORGANIK TERHADAP SIFAT KIMIA TANAH DAN PRODUKSI TANAMAN JAGUNG (Zea mays L.) DI TANAH ULTISOLNATAR PADA MUSIM TANAM KE DUA
Authors: Putra Ryandi Eka , Dermiyati Dermiyati , Afrianti Nur Afni , Buchari Henrie
Published: January 2020

Pupuk Organonitrofos merupakan pupuk organik yang dirakit dari bahan-bahan kotoran sapi segar, limbah MSG, sabut kelapa, Trichodermasp., serta mikroba penambat N dan pelarut P sehingga diharapkan dapat mengurangi penggunaan pupuk anorganik.  Penelitian ini bertujuan untuk mengetahui pengaruh pemberian kombinasi pupuk Organonitrofos dan pupuk anorganik terhadap pertumbuhan dan produksi tanaman jagung, dan melakukan uji Relative Agronomic Effectiviness (RAE) terhadap produksi jagung.  Penelitian dilakukan dengan menggunakan Rancangan Acak Kelompok (RAK) yang terdiri dari 11 perlakuan dan 3 ulangan.  Perlakuan adalah kombinasi pupuk Organonitrofos dan pupuk anorganik.  Hasil penelitian menunjukkan bahwa perlakuan kombinasi pupuk Organonitrofos dan anorganik pada T6 (100% Organonitrofos + 100% NPK) memberikan pengaruh terbaik terhadap fase generatif yang ditunjukkan padavariabel tinggi tanaman, bobot basah brangkasan bobot tongkol dengan kelobot dan bobot tongkol tanpa kelobot dan  merupakan dosis paling efektif secara agronomis karena memiliki nilai RAE 425%.  Terdapat korelasi yang nyata antara P-tersedia tanah dengan bobot tongkol berkelobot dan P-tersedia tanah dengan bobot tongkol tanpa kelobot jagung.