bluuebunny/crossref_metadata_2025 huggingface dataset:
Optimization of indicators of the modifi ed adaptive friction clutch
of the second generation
Authors: Shishkarev M.P.
Published: August 2023

A criterion for evaluating the effectiveness of increasing the gain of an adaptive friction clutch in the form of a coeffi
cient of compliance, which allows you to set, taking into account the use of the clutch in the drive of the machine, the
optimal value of the accuracy coeffi cient and the corresponding value of the gain. It is shown that if the mass of the elements
of the protected part of the drive exceeds the mass of the coupling at its initial minimum response accuracy by at
least 1.5...2 times, then the minimum value of the total mass of the protected part corresponds to the maximum response
accuracy of the coupling.
CLINICAL AND BEHAVIORAL PRACTICES OF PRIMARY HEALTHCARE PHYSICIANS IN ANTIBIOTICS PRESCRIBING IN GREECE
Authors: Toska Aikaterini , Latsou Dimitra , Saridi Maria , Fradelos Evangelos C. , Vus Viktor , Geitona Mary
Published: August 2023

Aim: To evaluate primary health physicians’ clinical and behavioral practices towards antibiotics administration in a specific region in Greece.
Materials and methods: A cross sectional study was conducted using a questionnaire in all structures of primary health care (PHC) of the Peloponnese Region. The study was conducted in May-October 2020.
Results: In total, 306 out of 404 primary healthcare physicians completed the questionnaire (response rate of 75.8%). Our results showed that most of physicians used to prescribing antibiotics empirically in common diseases, except for the prevention of secondary respiratory tract infection. Overall, 66.3% answered that they do not feel diagnostic uncertainty that would lead them to prescribe antibiotics. Approximately 40% of the physicians stated an increase on antibiotics use and patients demand for antibiotic prescribing, however 71.4% “rarely/never” affected by this requirement. 51.9% of the sample used to prescribed brand name antibiotics. Statistically significant differences were found between demographic and professional characteristics, and physicians’ clinical and behavioral practices (p≤ 0.05).
Conclusions: Our findings could provide decision makers with information on how to manage antibiotic prescribing in primary health care in the country, focusing mainly on the use of specific diagnostic tests as well as relevant guidelines and protocols for changing prescription behavior.
BURNOUT AND DEPRESSION OF GREEK HEALTHCARE PROFESSIONALS WORKING IN REFUGEES’ RECEPTION CENTERS AND ACCOMMODATION PROGRAMS
Authors: Apostolara Paraskevi , Adamakidou Theodoula , Mouta Evaggelia , Vus Viktor , Malliarou Maria , Mantzorou Marianna , Papathanasiou Ioanna V.
Published: August 2023

Aim: The investigation of health professionals’ burnout and depression, working in refugees’ reception centers and their possible intercorrelation.
Materials and methods: A descriptive correlation study was carried out in health professionals, who worked in refugees’ reception centers and accommodation programs throughout Greece. Data were collected using an anonymous questionnaire through online Google Forms. The questionnaire contained demographics, the Copenhagen Burnout Questionnaire (CBI-Gr) and the Patient Health Questionnaire (PHQ-9). The SPSS 22.00 was used for the statistical analysis and the significance level was set at 0.05.
Results: The sample consisted of 125 healthcare professionals working in refugees’ reception centers and accommodation programs, the majority of tchem were women (62.4%), aged between 30-39 years (39.2%) nurses (24.8%) and with a master's degree (28%). A strong linear positive correlation was found between depression and burnout (r=0.542, p=0.000). A statistically significant correlation was also recorded between burnout and female gender (p=0.001), the age group of 30-39 (p=0.042) and nursing profession (p=0.003).
Conclusions: A strong linear relationship between burnout and depression was revealed, a finding indicating that it is imperative to implement interventions to strengthen the resilience of health professionals working in refugees’ reception centers.
CLINICAL EFFICACY OF TREATMENT OF WOMEN WITH CHRONIC RECURRENT UROGENITAL CHLAMYDIA INFECTION
Authors: Kukhta O. P. , Aleksandruk O. D. , Neiko O. V. , Romash I. B. , Romash I. R. , Romash N. I. , Reevu Neogi
Published: August 2023

Aim: To to increase the efficacy of the treatment of women diagnosed with complicated urogenital chlamydia infection based on the study of the immune status, clinical and pathogenetic features of the course, development and implementation of pathogenetically substantiated therapy methods.
Materials and methods: Laboratory diagnostics of chlamydia infection was conducted with the use of direct immunofluorescence, enzyme immunoassay and cytological method. The dynamics of clinical symptoms was studied in the patients of Group I (64 women) who received Wobenzym in combination with Doxycycline and Group II (64 women) who were treated with conventional therapy (CT).
Results: Clinical effectiveness of the treatment of women in Groups I and II was analyzed. The treatment according to our developed method was well tolerated by all the patients. No manifestations of the disease exacerbation which could be associated with the inclusion of these drugs in the comprehensive treatment were noted. The insignificant effectiveness of our treatment in the examined patients with complicated urogenital chlamydia infection in Groups I and II was distributed as follows: only 1 (1.56%) woman (Group I) had an insignificant improvement in clinical manifestations after the treatment according to our method. An insignificant improvement in the clinical manifestations after the treatment with conventional therapy (Group II) was observed in 4 women constituting 6.25%. Unfortunately, a small percentage of women in Groups I and II with no changes in clinical symptoms after the treatment was observed. In particular, the absence of treatment effectiveness was noted in 3 (4.69%) women after the application of our method and in 6 women (9.38%) who were treated by the conventional therapy. Therefore, these women were prescribed an additional course of treatment.
Conclusions: The dynamics of clinical symptoms was found to be significantly more pronounced and fast in the patients of Group I compared to the patients in Group II who were treated with conventional therapy
FOURTH VENTRICLE ENTRAPMENT MANAGEMENT AND ITS OUTCOMES: CASE-SERIES FROM A SINGLE NEUROSURGERY CENTER
Authors: Meizikri Rizki , Parenrengi Muhammad Arifin , Suryaningtyas Wihasto
Published: August 2023

This case-series aims to report the elaborate management of FVEs in our center and their outcome. Data from 2017 to 2022 were retrospectively collected. We reviewed patient's demography, clinical findings, radiology results, operative procedures, and complications after surgery. Five patients with FVE diagnosis underwent neurosurgical procedures. The procedures include VP shunt, endoscopic cyst fenestration and fourth ventricle peritoneal shunt (FVPS). Out of five patients, 3 had favorable outcomes, 1 deceased, and 1 patient were still hospitalized. The underlying diseases varied from hemorrhage, cyst, infection, congenital, and neoplasm. FVE etiologies range from congenital to intraventricular hemorrhage complications and infection. VPS, FVPS, and endoscopic treatment with stenting or fenestration are surgical options for treating FVE patients. CSF diversion using shunt device is the simplest procedure. Patients with FVE in general have favorable outcome after CSF diversion of any method.
Developing Intercultural Competence as Part of Professional Qualifications. A Training Experiment
Authors: Korhone Kaisu
Published: August 2023

The internationalization and globalization of working life sets specific requirements on professional education including professionally integrated foreign language education, the overall goal of which should be intercultural competence.The paper discusses a training experiment in intercultural communication, especially the effectiveness of training in developing the various components of intercultural competence. The training experiment included both a face-to-face tuition period and a self-study period with a multimedia- and Web-based Culture-General Assimilator consisting of a number of critical incidents. The participants of the experiment were 117 Bachelor of Engineering students at Kajaani Polytechnic, Finland.Besides assessing the effectiveness of intercultural training, the experiment aimed at mapping out what kind of communicators the students are and would like to be, whether they are motivated to develop their intercultural competence, and what they think about intercultural competence as part of their professional qualifications.
Intercultural Transformation and Second Language Socialization
Authors: Shi Xingsong
Published: August 2023

In order to make a fuller interpretation of second language socialization processes in intercultural communication contexts, this study looks into the basic assumptions of language socialization and the tenets of intercultural transformation studies before arguing for the feasibility of weaving the two research paradigms to create a more inclusive theoretical framework of intercultural language socialization. An elaboration of such a framework holds promise to enable a more panoramic interrogation of the joint development of L2 learners’ language competence and sociocultural knowledge in complex intercultural communicative contexts. This effort will not only expand and enrich the two research paradigms themselves, but also compensate for the dearth of research in this interdisciplinary field.
Changing intercultural attitudes over time
Authors: Neto Félix
Published: August 2023

Diversity is increasing within the Europe, and in Portugal in particular, and higher education will likely play a key role in preparing people to function in this new environment. This study assessed the effectiveness of an Intercultural Relations course at changing student levels of attitudes towards diversity and feelings of self-worth. The results indicated that the course had a positive impact on the multicultural ideology and increased ethnic tolerance and self-esteem, but it had no impact on gender-role ideology and ageism.
Intercultural Communication in Letters of Recommendation
Authors: LIU Jing
Published: August 2023

The letter of recommendation (LR) as a means to communicate across different cultures for the purpose of applying for entering a university can be problematic. Using contrastive rhetoric analytic framework, this paper compares LRs written by Chinese and English native speaker professionals. Discussion of culturally situated interpretations of the LRs is based on interviews with university professors who have been on the admission committee. The findings show similarities in macro discourse structure but differences in discourse content between the LRs, which suggest that successful intercultural communication in LRs requires meticulous dialogue with the ‘other’ according to Bakhtin’s theory of dialogism. Unequal power relationship between writer and reader is also discussed from critical discourse analysis perspective.
Speaking to Domestics in Lebanon: Power Issues or Misguided Communication?
Authors: Haraty Nabelah , Oueini Ahmad , Bahous Rima
Published: August 2023

The Lebanese use a combination of Arabic and English telegraphic speech, along with gestures and other forms of speech adjustments to address their domestics. This pattern of inadequate speech is based on the misconception that domestics understand exactly the same way they speak. Using interviews, questionnaires, and participant observations, the researchers identified some of the underlying issues, power and trust, related to this form of fragmented speech. The investigators recommended that communication with domestics be in one language and in complete sentences, not only for the sake of language acquisition but to ensure a fair treatment of foreign helpers.
Cultural Marginality: Exploration of Self-Esteem and Cross Cultural Adaptation of the Marginalized Individual: An investigation of the second generation Hare Krishnas .
Authors: Horback Sachi , Rothery-Jackson Cheryll
Published: August 2023

The purpose of this study was to explore the cross-cultural adaptation of a sample of adults raised in the Hare Krishna culture. Fifteen second generation ISKCON (International Society for Krishna Consciousness) adults were asked to describe their family, peer, and social interactions and the perceived impact on their cross-cultural adaptation. An analysis of participant responses generated the following fifteen themes: (1) age and context of first contact with mainstream culture, (2) process of cultural adaptation, (3) parents’ marital status, (4) family relationships, (5) layers of marginality, (6) community norms and values, (7) identity crises, (8) self-esteem and self-esteem scores, (9) views of ISKCON culture, (10) views of mainstream culture, (11) cultural vernacular, (12) cultural emblems, (13) role models, (14) current cultural membership, and (15) future family vision. The outcome of the study was discussed with possible clinical issues which included the complexities of cultural belongingness, healthy and self-destructive aspects of adaptation, and feelings of terminal uniqueness.
The Image of Europe as Advertised in Russia
Authors: Hoffmann Edgar
Published: August 2023

This contribution analyses the image of Europe passed on in current TV-advertising in Russia. This image is only understandable in the context of the current social discussions about national identity and builds on the national self-images. While Russia is very markedly different to Europe in terms of size and importance, tradition and history as well as community and shared identity, the image of Europe is depicted as a homogenous, intrinsically less structured counterpart to the self-image. The image of Europe is based on difference, not on negative foreign stereotyping. As a result, Russia appears as not belonging to Europe.
Stone Man Syndrome: A Rare and Debilitating Genetic Disorder with a Misguided Immune Response
Authors: Dipankar Maiti  , Shilpa N.M
Published: August 2023

Stone Man Syndrome, also known as Fibrodysplasia Ossificans Progressiva(FOP), is a rare genetic disorder characterized by progressive bone formation and connective tissue ossification. The condition affects approximately 1 in 2 million people worldwide and typically becomes apparent during early childhood. Individuals with Stone Man Syndrome experience the formation of extra bone in their muscles, tendons, and ligaments, which eventually leads to joint immobility and skeletal abnormalities. The condition progresses gradually and often leads to the fusion of the spinal column and rib cage, resulting in respiratory problems and limited mobility. FOP is caused by a mutation in the ACVR1 gene, which encodes a protein involved in bone formation and repair. The mutation leads to the activation of a specific signalling pathway, causing the body to produce excess bone tissue in response to injury or trauma. Currently, there is no cure for Stone Man Syndrome, and treatment options are limited. Physicians can only manage the symptoms of the condition and help patients maintain mobility through physical therapy, pain management, and surgery. However, surgery can be risky due to the risk of triggering new bone formation. The diagnosis of Stone Man Syndrome is typically based on clinical evaluation and genetic testing. Early diagnosis is critical to developing effective treatment plans and providing support for patients and their families. In conclusion, Stone Man Syndrome is a rare genetic disorder characterized by the progressive formation of extra bone tissue, leading to joint immobility and skeletal abnormalities. Although there is currently no cure for the condition, early diagnosis and management of symptoms can improve patients’ quality of life.
Impact of Diabetic Neuropathy on Ankle Dorsiflexion in Older Adults
Authors: Soumya Kanti Das  , Hrishikesh S. Pai
Published: August 2023

Background: Diabetes mellitus is increasing among the population. If early diagnosis and treatment can be done, complications can be reduced. Although there are studies evaluating the impact of diabetes on joint motion, there are limited studies examining the ankle range of motion and its correlation with duration or severity of diabetic neuropathy symptoms. This study aims to examine the impact of diabetic neuropathy on angle of ankle dorsiflexion and it’s correlation with duration or severity of diabetic neuropathy symptoms Methods: Descriptive study in Government medical college, Thoothukudi. 72 patients attending the outpatient department of Medicine and Neuromedicine of a tertiary care hospital, ranging from 40 to 75 years were included in the study out of which 36 were diabetic with symptoms of diabetic neuropathy and 36 were non-diabetic. Ankle range of motion was measured using goniometer. Severity of neuropathy assessed using Toronto Clinical Neuropathy score and duration of diabetic neuropathy symptoms recorded. Results: Mean Age (Diabetic group) 59.28±8.06 Vs 56.08±10.16 (Non-Diabetic group). Proportion of patients with decreased angle of dorsiflexion among the patients with diabetic neuropathy (77.8%) was significantly higher than non-diabetic patients (47.2%) (Z=4.52;p<0.0001). Chi-square (2χ) test showed that there was significantassociation between severity of diabetic neuropathy and angle of dorsiflexion (in degree) of the patients with diabetic neuropathy (p<0.0001). Angle of dorsiflexion decreased significantly with severity of diabetic neuropathy. Pearson correlation co-efficient showed that there was significant negative correlation between duration of diabetic neuropathy and angle of dorsiflexion (r=-0.61;p<0.001). Thus with the increase in duration of diabetic neuropathy angle of dorsiflexion decreased significantly.Conclusions: It was found that the angle of ankle dorsiflexion was lower in diabetic patients as compared to non-diabetic patients It was also concluded that the duration of diabetic neuropathy and severity of sensory symptoms have an inverse relationship with ankle range of motion.
Peculiarities of Acromioplasty in Patients with Chronic Massive Rotator Cuff Ruptures
Authors: Strafun S.S. , Bohdan S.V. , Yuriichuk L.M. , Strafun O.S. , Biliavskyi V.O.
Published: August 2023

Background. According to the literature, from 14% to 28% of patients with rotator cuff tendon ruptures have unsatisfactory results of treatment and require a reverse shoulder joint arthroplasty in the future.

Objective: to compare the results of open rotator cuff repair of chronic massive rotator cuff tears in groups with standard subacromial decompression and subacromial decompression with resection of the lateral part of the acromion.

Materials and Methods. The study included 58 patients who underwent an open rotator cuff repair of chronic massive rotator cuff tears (supraspinatus and infraspinatus tendons) and who underwent a rehabilitation program and follow-up up to 12 months after surgery. The age of the patients ranged from 30 to 60 years. All patients were divided into 2 groups: group 1 – classic subacromial decompression, group 2 – classic subacromial decompression complemented by resection of 5 mm of the lateral end of the acromion. Shoulder joint function was assessed using the Constant Shoulder Score and VAS scales before surgery, 6 and 12 months after surgery.

Results. Six months after surgery, the mean functional result on the Constant Shoulder Score scale in group 1 was slightly worse (24.5 ± 16.2 points) than in group 2 (18.5 ± 6.1 points); p = 0.131. Twelve months after surgery, the mean functional score on the Constant Shoulder Score was 21.1 ± 5.6 points in group 1 and 10.1 ± 6.1 points in group 2 (p = 0.031). Six months after surgery, the average score on the VAS scale was worse in group 1 than in group 2 and ranged from 3.5 ± 1.2 points. Twelve months after surgery, the mean score on the VAS scale was also worse in group 1 than in group 2 (p = 0.05). Conclusions. Resection of the lateral part of the acromion during the open rotator cuff repair of chronic massive rotator cuff tendons tears allows to obtain better average functional results of treatment both 6 months and 12 months after the surgery. Resection of the lateral end of the acromion changes the vector of the total force of the rotator cuff and deltoid muscles during shoulder elevation. This reduces the probability of the subacromial conflict syndrome development and thus reduces the load on the area of the rotator cuff tendon suture.
Total Knee Arthroplasty for Contractures in Patients with Rheumatoid Arthritis
Authors: Herasymenko S.I. , Poluliakh M.V. , Babko A.M. , Herasymenko A.S. , Poluliakh D.M. , Kachan D.I. , Kostohryz Yu.O. , Duda M.S. , Huzhevskyi I.V.
Published: August 2023

Summary. Knee joint injury in patients with rheumatoid arthritis (RA) occurs in 70% of cases. This is the most common cause of loss of work capacity and the ability to selfcare; patients become severely disabled, since the disease is accompanied by contractures with the development of discordant positions of the lower limbs, which leads to a partial or complete loss of the function of support and walking. Thus, this problem needs to be studied.
Objective: to analyze the orthopedic treatment of secondary arthrosis of the knee joints in patients with RA, complicated by contractures.
Materials and Methods. In this study, we have analyzed the orthopedic treatment of 66 RA patients with secondary arthrosis with contractures, who underwent 75 total knee replacements between 2013 and 2020. Anamnestic data, clinical, biomechanical and statistical research methods were used.
Results. The analysis of the results of total knee replacement was followed in the period from 6 months to 5 years. The results were evaluated according to the 100-point scale by J. Joseph,
E.E. Kaufman (1550). The majority of patients had good treatment results.
Conclusions. Total knee replacement is required in patients with 2nd phase of the stage II of the disease and higher. In our opinion, this is the most optimal time for surgical treatment, which allows patients with RA to fully use the capabilities of an implanted endoprosthesis.
Systems for the Assessement of a Severe Injuried Limb. Suitability in the Modern War (Literature Review)
Authors: Liabakh A.P.
Published: August 2023

Summary. The review of the literature is devoted to the consideration of systems for assessing a seriously injured (mangled) extremity and their suitability in combat conditions: HFS-57, MESI, PSI, LSI, MESS, NISSSA, GHOISS, MUES. A search was carried out on the PubMed database for the period 1578-2023. Advantages and disadvantages are shown. The most used for combat limbs injury is MESS.
The Use of Injection Methods for the Prevention and Treatment of Post-Traumatic Osteoarthritis of the Ankle Joint (Literature Review)
Authors: Turchyn O.A. , Omelchenko T.M. , Liabakh A.P.
Published: August 2023

Summary. Treatment of post-traumatic osteoarthritis (OA) of the ankle joint remains an issue of modern orthopedics. Conservative therapy may lose its effect over time or cause considerable side effects. Intra-articular injections are successfully used in the treatment of ОA in other major joints, so it has been hypothesized that they also may be effective in patients with ankle OA.

Objective: to analyze the literature devoted to injection methods of treatment of post-traumatic ankle OA.

Material and Methods. The search for publications which evaluated the effectiveness of intra-articular therapy in reducing pain and improving function in the treatment of ankle OA was conducted on PubMed databases, from 2007 to 2022. Intra-articular therapy included corticosteroids (CS), hyaluronic acid (HA), platelet-rich plasma (PRP), mesenchymal stem cells (MSC), botulinum toxin A (BoNT-A), prolotherapy, and bone marrow aspirate.

Results. 146 publications related to intra-articular therapy in the treatment of ankle OA were found. 40 publications were selected for analysis, of which there were 11 randomized controlled studies and 4 meta-analyses; other publications were of III and IV levels of evidence. The number of literature sources related to the effectiveness of intra-articular therapy was as follows: HA – 24, CS – 3, BoNT-A – 1, PRP – 5, MSc – 1, prolotherapy – 2, and bone marrow aspirate – 1.

Conclusions. Intra-articular therapy may be effective in the treatment of post-traumatic OA of the ankle joint. However, modern literature data in this area are mostly of poor quality and consist of small sample studies. Since there are currently no studies comparing these techniques, it is difficult to determine whether one type of injection therapy should be preferred over another. This determines the need for further research, especially regarding the criteria for evaluating the effectiveness and long-term safety of these treatments.
Anterior Cruciate Ligament Injury: What Are Trends in Treatment?
Authors: Zazirnyi I.M. , Andreev A. , Kostrub O.O. , Kotiuk V.V.
Published: August 2023

Summary. There has been a reemergence of investigation into Anterior Cruciate Ligament (ACL) repair as a surgical option for patients presenting with an ACL rupture. Despite high historical failure rates, new innovations have been implemented to improve stability and biointegration in an effort to aid healing of the ligament and decrease failure rates following ACL repair. The evolution of surgical techniques has seemingly led to improved short-term outcomes over historical reports. However, there remains a paucity of literature on long-term outcomes, large series, and comparison among repair techniques. Furthermore, there have been no high-quality studies showing outcomes comparable with those after ACL reconstruction. While advancements in ACL repair have been encouraging, there are no data, to our knowledge, to support ACL repair over ACL reconstruction, as recent reports have shown high failure rates after ACL repair. For these reasons, at the present time, ACL reconstruction should remain the gold standard treatment for patients with functional impairment from an ACL rupture. In the future, there may be a role for ACL repair for select tear types in specific individuals, if the early ACL repair outcome studies produce consistent long-term outcomes comparable with those after ACL reconstruction.
Đánh giá độc tính phác đồ r-chop trên bệnh nhân u lympho ác tính không hodgkin điều trị tại bệnh viện trung ương huế
Authors: QUANG PHI PHAM
Published: August 2023

TÓM TẮT

Mục tiêu: Đánh giá độc tính của phác đồ R-CHOP trong điều trị bệnh nhân u lympho ác tính không Hodgkin típ tế bào B lớn lan toả CD20 dương tính tại Bệnh viện Trung ương Huế.

Đối tượng, phương pháp: Nghiên cứu mô tả tiến cứu trên 37 bệnh nhân u lympho ác tính không Hodgkin típ tế bào B lớn lan toả CD20+ điều trị bước một bằng phác đồ R-CHOP tại Bệnh viện Trung ương Huế từ tháng 3/2017 đến tháng 6/2020. Đánh giá độc tính theo WHO. Xử lý số liệu bằng các thuật toán thống kê y học, sử dụng phần mềm SPSS 20.0.

Kết quả: Độc tính giảm bạch cầu hạt chiếm 70,2% trong đó giảm độ 4 là 13,5%. Có 2 bệnh nhân sốt giảm bạch cầu hạt với tỷ lệ 5,4%. Về chức năng gan, thận, 35,1% tăng SGOT; 21,6% tăng SGPT trong đó 5,4% tăng men gan độ 4. 67,6% bệnh nhân có buồn nôn-nôn, 100% bênh nhân rụng tóc; 5,4% tiêu chảy; 8,1% viêm da-niêm mạc; độc tính tim mức độ nhẹ 13,5%. Chỉ có 2 bệnh nhân có phản ứng với Rituximab ở lần truyền đầu tiên với tỷ lệ 5,4% bao gồm 1 trường hợp phản ứng độ 1 và 1 trường hợp độ 3, không gặp trường hợp nào phản ứng ở những lần truyền sau. Tỷ lệ tái hoạt hóa HBV ở nhóm HbsAg(-) và ở nhóm HbsAg(+) lần lượt là 8,0% và 8,3%.

Kết luận: Phác đồ R-CHOP điều trị bước 1 u lympho ác tính không Hodgkin típ tế bào B lớn lan tỏa CD20+ là một phác đồ có hiệu quả cao, độc tính ít gặp và ở mức độ nhẹ.

ABSTRACT

TOXICITY EVALUATION OF R-CHOP FOR NON HODGKIN LYMPHOMA TREATED AT HUE CENTRAL HOSPITAL

Objective: Evaluating toxicities of R-CHOP in treating Diffused large B cell Non Hodgkin Lymphoma with CD20+ at Hue Central Hospital.

Methods: progressive descriptive study on 37 patients diagnosed with Diffused large B cell Non Hodgkin Lymphoma with CD20+ at Hue Central Hospital from 03/2017 to 06/2020. Toxicities were evaluated by WHO grading system. Data were analyzed by medical statistics algorithms SPSS 20.0.

Results: Neutropenia was 70.2%, grade IV was 13.5%. Elevated SGOT and SGPT were 35.1% and 21.6%, respectively, including 5.4% with elevated common transaminase. Other adverse effects including nausea - vomiting, alopecia, diarrhea, mucositis and cardiac toxicity were 67.6%, 100%, 5.4%, 8.1% and 13.5%, respectively. There were two patients with hypersensitivity on Rituximab at the first infusion (5.4%), including one grade I and one grade III, there was no hypersensitivity in the later infusions. Rate of HBV-reactive in HbSAg (-) and HbSAg (+) were 8.0% and 8.3%, respectively.

Conclusions: First line R-CHOP for Diffused large B cell Non Hodgkin Lymphoma with CD20+ is an effective regimen with good response, uncommon and less toxicities.
Investigating the Origin of the Absorption-line Variability in the Narrow-line Seyfert 1 Galaxy WPVS 007
Authors: Green Kaylie S. , Gallagher Sarah C. , Leighly Karen M. , Choi 최 Hyunseop 현섭 , Grupe Dirk , Terndrup Donald M. , Richards Gordon T. , Komossa S.
Published: August 2023

Broad absorption line quasars are actively accreting supermassive black holes that have strong outflows characterized by broad absorption lines in their rest-UV spectra. Variability in these absorption lines occurs over months to years depending on the source. WPVS 007, a low-redshift, low-luminosity narrow-line Seyfert 1 (NLS1) shows strong variability over shorter timescales, providing a unique opportunity to study the driving mechanism behind this variability that may mimic longer-scale variability in much more massive quasars. We present the first variability study using the spectral synthesis code SimBAL, which provides velocity-resolved changes in physical conditions of the gas using constraints from multiple absorption lines. Overall, we find WPVS 007 to have a highly ionized outflow with a large mass-loss rate and kinetic luminosity. We determine the primary cause of the absorption-line variability in WPVS 007 to be a change in covering fraction of the continuum by the outflow. This study is the first SimBAL analysis where multiple epochs of observation were fit simultaneously, demonstrating the ability of SimBAL to use the time domain as an additional constraint in spectral models.
The EDGE-CALIFA Survey: Spatially Resolved 13CO(1–0) Observations and Variations in 12CO(1–0)/13CO(1–0) in Nearby Galaxies on Kiloparsec Scales
Authors: Cao Yixian , Wong Tony , Bolatto Alberto D. , Leroy Adam K. , Rosolowsky Erik , Utomo Dyas , Sánchez Sebastián F. , Barrera-Ballesteros Jorge K. , Levy Rebecca C. , Colombo Dario , Blitz Leo , Vogel Stuart N. , Puschnig Johannes , Villanueva Vicente , Rubio Monica
Published: August 2023

We present 13CO(J = 1 → 0) observations for the EDGE-CALIFA survey, which is a mapping survey of 126 nearby galaxies at a typical spatial resolution of 1.5 kpc. Using detected 12CO emission as a prior, we detect 13CO in 41 galaxies via integrated line flux over the entire galaxy and in 30 galaxies via integrated line intensity in resolved synthesized beams. Incorporating our CO observations and optical IFU spectroscopy, we perform a systematic comparison between the line ratio

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12

/

13

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I

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CO
(
J
=
1
→
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)
]

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CO
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=
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0
)
]

and the properties of the stars and ionized gas. Higher

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12

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13

values are found in interacting galaxies compared to those in noninteracting galaxies. The global



12

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13

slightly increases with infrared color F
60/F
100 but appears insensitive to other host-galaxy properties such as morphology, stellar mass, or galaxy size. We also present azimuthally averaged

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12

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13

profiles for our sample up to a galactocentric radius of 0.4r
25 (∼6 kpc), taking into account the 13CO nondetections by spectral stacking. The radial profiles of



12

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13

are quite flat across our sample. Within galactocentric distances of 0.2r
25, the azimuthally averaged



12

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13

increases with the star formation rate. However, Spearman rank correlation tests show the azimuthally averaged



12

/

13

does not strongly correlate with any other gas or stellar properties in general, especially beyond 0.2r
25 from the galaxy centers. Our findings suggest that in the complex environments in galaxy disks,



12

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13

is not a sensitive tracer for ISM properties. Dynamical disturbances, like galaxy interactions or the presence of a bar, also have an overall impact on

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, which further complicates the interpretations of

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variations.
Analytic Understanding of the Resonant Nature of Kozai–Lidov Cycles with a Precessing Quadrupole Potential
Authors: Klein Ygal Y. , Katz Boaz
Published: August 2023

The very long-term evolution of the hierarchical restricted three-body problem with a slightly aligned precessing quadrupole potential is studied analytically. This problem describes the evolution of a star and a planet that are perturbed either by a (circular and not too inclined) binary star system or by one other star and a second more distant star, as well as a perturbation by one distant star and the host galaxy or a compact-object binary system orbiting a massive black hole in nonspherical nuclear star clusters. Previous numerical experiments have shown that when the precession frequency is comparable to the Kozai–Lidov timescale, long-term evolution emerges that involves extremely high eccentricities with potential applications for a broad scope of astrophysical phenomena, including systems with merging black holes, neutron stars, or white dwarfs. By averaging the secular equations of motion over the Kozai–Lidov cycles (KLCs), we solve the problem analytically in the neighborhood of the KLC fixed point where the eccentricity vector is close to unity and aligned with the quadrupole axis and for a precession rate similar to the Kozai–Lidov timescale. In this regime the dynamics is dominated by a resonance between the perturbation frequency and the precession frequency of the eccentricity vector. While the quantitative evolution of the system is not reproduced by the solution far away from this fixed point, it sheds light on the qualitative behavior.
Lionfish (Pterois miles) in the Mediterranean Sea: a review of the available knowledge with an update on the invasion front
Authors: Bottacini Davide , Pollux Bart J. A. , Nijland Reindert , Jansen Patrick A. , Naguib Marc , Kotrschal Alexander
Published: August 2023

Invasive species often severely impact ecosystems and human activities in the areas that they invade. Lionfishes (Pterois miles and P. volitans) are regarded as the most successful invasive fishes in marine ecosystems. In the last 40 years, these Indo-Pacific predators have colonised the tropical western Atlantic Ocean, with well-documented detrimental effects on the local fish communities. Around 10 years ago, a second invasion began in the Mediterranean Sea. Given the invasive potential of lionfish and the fact that the ecology and biodiversity of the temperate/sub-tropical Mediterranean offer a different setting from the tropical western Atlantic, specific knowledge on this second invasion is needed. Here, we (i) provide a citizen science-based update on the location of the invasion front in the Mediterranean, (ii) review the scientific knowledge available on the ecology of invasive lionfish, (iii) discuss such knowledge in the context of invasion ecology and (iv) suggest future research avenues on the lionfish invasion in the Mediterranean. While the history and development of the Mediterranean invasion are resolved and some mitigation plans have been implemented locally, the study of the interactions of lionfish with Mediterranean species and their impact on the local biodiversity is in its infancy. Closing this gap will lead to important fundamental insights in invasion ecology and will result in predictions on the impact of lionfish on the ecology and ecosystem services of the Mediterranean. Such information will have practical implications for policy makers aiming to devise sound and efficient mitigation plans.
Planetary Knowledge Base: Semantic Transcription Using Graph Neural Networks
Authors: Gu Qianqian , Scott Ben , Smith Vincent
Published: August 2023

The Natural History Museum, London (NHM), in collaboration with Amazon Web Services (AWS), has embarked on a project to build the Planetary Knowledge Base (PKB), a comprehensive graph network comprising data on all specimens, collectors, and localities. In the initial prototype, we have concentrated on botanical specimens, using all plant taxa and specimens within the Global Biodiversity Information Facility (GBIF), combined with geographic data from GeoNames and biographic data from WikiData, Bionomia, Harvard Index of Botany, TL2, and Tropicos. Development of the PKB is a huge undertaking—our first proof of concept has more than 100 million nodes.

The primary application of this knowledge graph (KG) is powering the automated transcription of specimen labels. Using Graph Convolutional Neural Networks, textual information from labels can be aligned to the entities in the graph, creating structured semantic data from the raw text. Text is extracted from images using services from the AWS ecosystem, including Optical Character Recognition and Natural Language Processing to identify the units of information, creating a high-throughput auto-digitisation workflow for extracting structured data.

The PKB graph network enables new ways to interrogate collections. It can help identify species that may require re-examination or re-identification due to taxonomic updates or inconsistencies. It can also flag potential discrepancies or conflicts in the data, such as cases where the same species is recorded under different names or classifications across various sources. Moreover, the PKB can detect possible errors and outliers in the knowledge graph and point out specimens that could represent new species misidentified within the collection. By cross-validating species with the International Union for Conservation of Nature (IUCN) Red List, it can also assist in analysing species populations with insufficient data.

The PKB is being developed as a cloud service, so researchers and other institutions can experiment with this transformative technology, using it to support their own digitisation efforts.
WFO-IDs: Unique Identifiers for All Known Plants Managed by the World Flora Online
Authors: Miller Chuck , Berendsohn Walter , Ulate William , Hyam Roger
Published: August 2023

The World Flora Online (WFO) project (Borsch et al. 2020) was initiated in 2012 in response to Target 1 of the Global Strategy for Plant Conservation*1, "To create an online flora of all known plants by 2020" (Wyse Jackson and Kennedy 2009). A WFO Consortium of over 40 international institutions has been formed. The World Flora Online Public Portal*2 is built upon a taxonomic backbone of plant taxonomic data that integrates the International Plant Name Index (IPNI)*3, World Checklist of Vascular Plants (WCVP)*4, Tropicos*5, Angiosperm Phylogeny Group 4*6, Pteridophyte Phylogeny Group (PPG I 2016), supplemented by the Global Compositae Checklist*7, Solanaceae Source*8, and others. To facilitate the ongoing curation of the WFO backbone, identifiers called WFO-IDs have been created for each of the over 1.59 million names included in WFO. WFO-IDs are comprehensive for all known plants, both vascular and non-vascular except algae. IPNI-IDs are limited to vascular plants and do not give the current taxonomic status of the name. WFO-IDs also cover invalid designations, i.e., some effectively published “names” like orthographic variants that have been used in taxonomic literature, so that their invalid status is made explicit. WFO IDs follow FAIR principles (Findable, Accessible, Interoperable, and Reusable). Relationships between WFO-IDs are also recorded by the WFO Taxonomic Backbone, including synonymy and homonymy, and are accessible via the WFO Portal. WFO is continuously updating the taxonomic backbone by engagement of new plant Taxonomic Expert Networks (TENs) focused on selected plant groups. WFO also includes over 500,000 descriptive data items gathered from digital floras and monographs, and other sources. Descriptive data can be text descriptions, images, geographic distributions, identification keys, phylogenetic trees, threat status, lifeform or habitat. Descriptive data records are all assigned a WFO-ID, if they are new to WFO, by a name matching process with the WFO Taxonomic Backbone. A new tool called Rhakhis (Hyam et al. 2022), developed at Royal Botanic Garden, Edinburgh, is used to manage the WFO Taxonomic Backbone data and includes APIs to access the versioned backbone data. This presentation will review the origins and history of WFO-IDs and how they are being used for the World Flora Online.
Mechanical properties of graphene nanoplatelets reinforced glass/epoxy composites manufactured using resin film infusion process
Authors: Wayzode Neerajkumar , Suryawanshi Vinod
Published: August 2023

Nanofillers as secondary reinforcement in polymeric composites have shown promising results on improvement of mechanical properties of the polymeric composites. However, due to the in-plane resin path, filtration of the nanofillers through fabric during processing is a major challenge in liquid infusion processes such as resin transfer molding. In resin film infusion process, the resin travels in thickness direction and due the shorter resin path, the possibility of filtration is minimal. In this study, resin film infusion (RFI) process is used to fabricate graphene platelets reinforced glass/epoxy hybrid composites. First, the resin films with 0.4 and 0.8 percent of graphene nanoplatelets (GNPs) were manufactured using solvent casting process. Then, these films were used to fabricate composites using resin film infusion process. Mechanical characterization tests, namely tensile, flexural and short beam, were performed. Tensile strength of the 0.4% and 0.8% GNPs reinforced composites was 36.13% and 22.23% higher, respectively, than that of baseline composites. Flexural strength 0.4% and 0.8% GNPs modified composites was 24.96% higher and 32% lower, respectively, compared to baseline composite. Lastly, minimal change was observed in short beam shear strength due to GNPs reinforcement. Higher void volume fraction of 1.7% and 4.5% as compared to baseline composites observed in 0.4% and 0.8% GNPs modified composites respectively.
Dynamic complexity of a slow-fast predator-prey model with herd behavior
Authors: Suleman Ahmad , Ahmed Rizwan , Alshammari Fehaid Salem , Shah Nehad Ali
Published: August 2023

The complex dynamics of a slow-fast predator-prey interaction with herd behavior are examined in this work. We investigate the presence and stability of fixed points. By employing the bifurcation theory, it is shown that the model undergoes both a period-doubling and a Neimark-Sacker bifurcation at the interior fixed point. Under the influence of period-doubling and Neimark-Sacker bifurcations, chaos is controlled using the hybrid control approach. Moreover, numerical simulations are carried out to highlight the model's complexity and show how well they agree with analytical findings. Employing the slow-fast factor as the bifurcation parameter shows that the model goes through a Neimark-Sacker bifurcation for greater values of the slow-fast factor at the interior fixed point. This makes sense because if the slow-fast factor is large, the growth rates of the predator and its prey will be about identical, automatically causing the interior fixed point to become unstable owing to the predator's slow growth.
Priest, Woman and Mother: Broadening the Horizons through Transgender/nachchi Identities in Sri Lanka
Authors: Ariyarathne Kaushalya
Published: August 2023

This article is based on a case study of (the pseudonymous) Karu Māmā’s life as a gurunnānse, his community, his practices and ultimately the negotiation of his identity as a transgender person within his community. To be more precise, it explores the lives of Karu Māmā and his transgender/nachchi (a local term used by a particular transgender group in Sri Lanka) daughters around the little Pattini shrine in his house and the annual gammaduwa ritual he performs as goddess Pattini. This ritual, I argue, is a unique illustration of his transgender and embodied performativity. It reminds us of the fact that we need to revisit and rewrite certain established discourses on transgenderism in Sri Lanka. Karu Māmā, who grew up with heteronormative, Sinhala-Buddhist discourses on birth, rebirth, family, notions of good and bad, as well as perspectives of gender, counters those dominant ideologies through his practices around his Pattini shrine and associated rituals. Moreover, I argue that this case study challenges the divisions that exist between genders, social classes, and castes around the Pattini ritual and narrates new interpretations. On the one hand, the rituals and practices associated with the Pattini dēvālaya in Daluwatte make a significant contribution to transgender identity negotiation. On the other hand, through well-known discourses of traditions, practices, rituals, and worshipping, this offers us new insights into motherhood, femininity, sexuality, and gender in contemporary Sri Lanka.
A neonate with metatropic dysplasia: A case report
Authors: Wettasinghe M. C. , Herath N. , Halangoda E. , Wickramasinghe N. D.
Published: August 2023

Metatropic dysplasia is a rare form of skeletal dysplasia in which characteristic clinical and imaging features are found at birth. The short limbs with relatively long trunk seen in the neonatal period change to short trunk in childhood due to progressive kyphoscoliosis. This rare condition should be diagnosed in the neonatal period to avoid diagnostic dilemma in later life. A 2-day-old baby girl was referred for a skeletal survey study to diagnose the underlying skeletal dysplasia. The metatropic dysplasia was diagnosed based on plain radiographic findings. This case report highlights the characteristic radiographic findings of this rare disease entity.
The impact of the COVID-19 pandemic on erectile function in Chinese CP/CPPS patients
Authors: Song Wei-Jie , Huang Ji-Wei , Liu Yuan , Ding Wei , Long Zhi , He Le-Ye
Published: August 2023

This study aimed to investigate the impact of the coronavirus disease 2019 (COVID-19) pandemic on erectile function in Chinese patients with chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS). A retrospective study was conducted on 657 CP/CPPS patients who visited The Third Xiangya Hospital of Central South University (Changsha, China) from November 2018 to November 2022. Patients were divided into two groups based on the timeline before and after the COVID-19 outbreak in China. The severity of CP/CPPS, penile erection status, anxiety, and depression was evaluated using the National Institutes of Health-Chronic Prostatitis Symptom Index (NIH-CPSI), International Index of Erectile Function-5 (IIEF-5), Generalized Anxiety Disorder-7 (GAD-7), and Patient Health Questionnaire-9 (PHQ-9) scales, respectively. Compared with patients before the COVID-19 outbreak, more CP/CPPS patients developed severe erectile dysfunction (ED) due to depression and anxiety caused by the pandemic. After developing moderate-to-severe ED, mild and moderate-to-severe CP/CPPS patients exhibited more apparent symptoms of anxiety and depression (P < 0.001 and P = 0.001, respectively), forming a vicious cycle. The COVID-19 pandemic has adversely affected the psychological status of CP/CPPS patients, exacerbating their clinical symptoms and complicating ED. The exacerbation of clinical symptoms further worsens the anxiety and depression status of patients, forming a vicious cycle. During the COVID-19 pandemic, paying more attention to the mental health of CP/CPPS patients, strengthening psychological interventions, and achieving better treatment outcomes are necessary.