bluuebunny/crossref_metadata_2025 huggingface dataset:
The Synergistic Effect of Ruthenium Complex Δ-Ru1 and Doxorubicin in a
Mouse Breast Cancer Model
Authors: Tang Xing-Guo , Lin Ke , Guo Shun-Wen , Rong Yi , Chen Dan , Chen Zhe-Sheng , Ping Feng-Feng , Wang Jin-Quan
Published: June 2022

Background:

Doxorubicin is a significant drug for the treatment of breast cancer, but its cardiotoxicity is an obvious obstacle. Previously, we confirmed that ruthenium complex (Δ-Ru1) and doxorubicin (Δ-Ru1/Dox) combination had a synergistic effect in MCF-7 cells, but its biological ef-fect in vivo is unknown.

Purpose:

To find a way to overcome the toxicity of doxorubicin and build MCF-7 xenograft tumor mouse model to test whether this potential combination has better efficacy and less toxicity.

Methods:

The tumor model of nude mice was established to verify the synergistic antitumor effect of the drug combination in vivo. H&E staining was used to detect the toxicity of major organs in mice. Sirius red staining and transmission electron microscopy were used to detect cardiotoxicity. Prussian blue was used to measure iron accumulation in heart tissue. TUNEL staining was used to detect the antitumor effect in vivo. Immunohistochemical staining was used to detect the expression of iron death-related pathway proteins. High-throughput sequencing techniques were used to determine the molecular mechanism of ferroptosis.

Results:

Histopathological analysis of tumor tissues indicated that the Δ-Ru1/Dox combination sig-nificantly promoted tumor cell apoptosis. Doxorubicin damaged cardiac tissue by inducing fibrosis and iron accumulation, but it was reversed by the Δ-Ru1/Dox combination treatment. Further explo-ration found that doxorubicin could regulate iron accumulation in the ferroptosis pathway and the expression of lipid peroxidation-related proteins, including upregulation of Tf, DMT1, and HO-1, and downregulation of Nrf2, SLC7A11, and GPX4.

Conclusion:

Δ-Ru1/Dox combination synergistically inhibits tumor growth, and it can significantly reduce and alleviate the toxic side effects of doxorubicin, especially cardiac injury.
The Levels of Cognitive Flexibility and Cognitive Resilience and their Relationships with Academic Performance in College Students
During the COVID-19 Pandemic
Authors: Ram Dushad , Alammar Muath A. , Albarragi Khudhayr Nasser , Alshahrani Abdullah Saad
Published: June 2022

Introduction:

Cognitive flexibility and resilience may influence academic achievement. These cognitive functions may be affected during the Covid 19 pandemic. Few studies have been conducted to examine these relationships.

Objective:

This study examined college students' cognitive flexibility and resilience and their relationships with academic achievement during the Covid 19 pandemic.

Methods:

In this cross-sectional study, 303 students were assessed using sociodemographic and academic proforma, the Cognitive Flexibility Scale, and the Cognitive Resilience Scale. The data were analyzed using descriptive statistics, contingency table analysis, the Kruskal–Wallis H test, the Mann–Whitney U test, and linear regression analysis (with moderation).

Results:

Cognitive flexibility was significantly greater in those who were success-oriented, had a backlog, and studied a health science subject, whereas resilience was greater in those who had lower course competency and had encountered psychological issues. Exam scores were positively linked with students' economic status and negatively linked with students' perceptions of course competency. Cognitive resilience predicted exam performance positively, which was moderated by cognitive flexibility.

Conclusion:

Cognitive resilience positively affects academic performance and is moderated by cognitive flexibility.
Energy Sufficiency of Biomass and Wastewater in Closed Process of Sago Starch Production
Authors:   IPB University, Bantacut Tajuddin , Indriyani Fitria ,   IPB University
Published: June 2022

Sago grows in lowland and peat swamp regions that are relatively isolated due to limited basic infrastructures, including energy supply, especially electricity. These limitations constraining the development of sago starch production and industry. The sago starch production process generates by-products such as sago bark waste, pith waste, and wastewater which are potentially used as an energy source. This paper discusses a closed system model of an energy-independent sago starch production process from the utilization of by-products and wastewater. A mass balance model was developed to calculate the energy potency of by-products and waste to construct a closed system for the sago starch production process. The model's output showed that the by-product from processing 1,000 tons of sago stems per day with an optimal yield of 14% potentially generates 90,562 kWh of energy. This energy potency can meet the 26,070 kWh energy needed for sago starch production, making it possible to develop into a closed production system. Further research is needed to determine the site-specific aspects that affect energy sufficiency.
Shelf-Life Prediction of Shallot Powder Using Accelerated Shelf-Life Testing (ASLT) Method by the Arrhenius Equation Approach
Authors:   IPB University, Permatasari Niken Ayu , Hardiyanti Indah ,   IPB University, Suryani Ani ,   IPB University, Yuliasih Indah ,   IPB University
Published: June 2022

The storage process of shallot powder can cause a quality decrease. This study aims to estimate shelf-life of shallot powder at various storage temperatures and determine quality changes during storage. This study used a Completely Randomized Design with two factors to determine quality changes of shallot powder, i.e. the coating and storage temperature. The statistical analysis results showed that the coating, storage temperature, and interaction between the two factors affected Volatile Reducing Substances (VRS) levels. The two factors and their interaction do not influence the water content. Shelf-life estimation was performed using the Arrhenius method. Coated shallot powder has a longer shelf-life than uncoated shallot powder. Shelf-life determination was performed based on water content parameters. The shelf-life of uncoated shallot powder was 337 days at 30 °C, 322 days at 40 °C, and 309 days at 50 °C. The shelf-life of coated shallot powder was 353 days at 30 °C, 340 days at 40 °C, and 328 days at 50 °C. The coating process can extend the shelf-life of shallot powder.
Sauce Product Development with Black Garlic Addition as a Flavour Enhancer and Antioxidant
Authors:   Universitas Jember, Herlina Herlina , Vionita Riska Rahma ,   Universitas Jember, Sulistiyani Sulistiyani ,   Universitas Jember, Nurhayati Nurhayati ,   Universitas Jember, Lindriati Triana ,   Universitas Jember
Published: June 2022

This study aims to determine the variations effect of black garlic concentration on the sauce's physical, chemical, and organoleptic characteristics. The experimental design used was a Completely Randomized Design with a single factor, the ratio of black garlic concentration to sauce paste. The experiment was performed with five treatments and three replications. The ratio of black garlic concentration to the sauce paste in this experiment was 5:95 (A1), 10:90 (A2), 15:85 (A3), 20:80 (A4), and 25:75 (A5). The results showed that the black garlic concentration significantly affected the sauce's physical and chemical characteristics (Total Dissolved Solids (TDS), color intensity, viscosity, antioxidant activity, and total polyphenols). The organoleptic test showed that black garlic concentration significantly affected panelists' preference for color, taste, viscosity, and overall parameters and did not significantly affect aroma preference. The best treatment was the sauce with a 15:85 (A3) concentration ratio of black garlic to sauce paste. The best treatment sauce's physical characteristics were 34.23±0.17 °Brix TDS, 1.35±0.12 color intensity, and 0.41±0.05 Poise viscosity, while the chemical characteristics were 22.75±0.38% antioxidant activity and 1.07±0.21 mg GAE/g total polyphenols. The organoleptic test of the best treatment sauce's results was 5.97 color preference, 5.30 aroma, 5.57 taste, 5.43 viscosity, and 5.23 overall preference.
Simple Vision System for Apple Varieties Classification
Authors:   Institut Teknologi Sepuluh Nopember, Nasution Aulia Muhammad Taufiq , Amrullah Syakir Almas ,   Center for Textile, Ministry of Industry Republic of Indonesia
Published: June 2022

Every variety of apple has its particular physical characteristics, which are affected by different pre-harvest factors. Manual classification of these varieties by human labor has several weaknesses, such as the inconsistency, subjectivity, fatigue and different accuracy due to different level of experience of the inspector. This study was aimed to design and evaluate a simple computer-based vision system for recognizing and grading several varieties of apples based on their physical characteristics. Images of apples were taken and were used as training data with different algorithms to extract the particular characteristics of each variety, such as color and shape. The extracted Hue color channels and contour vector were recorded as the reference data and were used to recognize the similar characteristic of those images from the testing data group. The k-nearest neighbors algorithm was used to decide whether an apple belongs to a particular variety. The results show that the recognition rate based on color only was between 84–97% and it was between 5–77% it is based on the shape only. Rotating the image significantly increases the recognition rate (to be between 5 - 69% based on the shape only). Moreover, combining both color and shape characteristics significantly improves the recognition rate.
MODEL TUTUPAN LAHAN DI DAERAH ALIRAN SUNGAI KOTA AMBON TAHUN 2031MODEL TUTUPAN LAHAN DI DAERAH ALIRAN SUNGAI KOTA AMBON TAHUN 2031: STUDI KASUS DAS WAI BATU GANTUNG, WAI BATU GAJAH, WAI TOMU, WAI BATU MERAH DAN WAI RUHU
Authors: Rakuasa Heinrich , Sihasale Daniel Anthoni , Latue Philia Christi
Published: June 2022

Changes in land use/land cover (LULC) in watersheds of Ambon City are influenced by human activities,mostly driven by socio-economic factors. Changes in land use/land cover (LULC) in the watershed in thecenter of Ambon City have the potential to trigger land-use change which will have an impact on landdegradation, water pollution, flooding, and erosion which will increase in the future. Therefore, theutilization and efficiency of land cover in the watershed area must be increased based on rational land cover planning. The objectives of this study were to analyze land cover changes in watersheds in Ambon City in 2012, 2017, and 2022 and predict land cover in 2031. This study used Cellular Automata Markov Chan (CA-MC) and six factors driving the development of settlements. The results showed that from 2012, 2017, and 2022, the land cover for settlements and open land in the watershed in Ambon City continued to increase, while the land cover for non-agricultural areas and agricultural areas decreased in the area. In 2031, residential land has an area of 1,863.34 ha; this is because the residential land cover will continue to increase along with population growth and high demand for land in watersheds.
Kajian Pencegahan dan Penanggulangan Kebakaran pada Pasar Tradisional Lawang
Authors: Damayanti Fifi , Ningrum Diana
Published: June 2022

This research starts from the market paradigm associated with dirty, slum, exceeding capacity so it is prone to fire. How do you solve this problem? This study discusses what elements are improving and managing disasters in traditional markets. The originality of this research seeks to study what elements affect disaster mitigation in market buildings with two analyzes, namely: (1) analysis of existing data and (2) inductive analysis. Literature review in this study comes from PermenPU No.26 / PRT / M / 2008, specifically about the completeness of the site in the traditional market environment, rescue facilities in the traditional market environment, active protection systems and protection of traditional market buildings. This research strategy uses descriptive, qualitative strategies. Related to collecting data, this study uses field observations consisting of: field measurements, field installations, field sketches and in-depth interviews. In the analysis of research data applying two types, namely: (1) analysis of existing data and (2) inductive analysis. The results obtained in this study are summarized into 4 (four) main categories and 9 (nine) observation units/variables. The purpose of this study is a diagram about not forming fire mitigation in the traditional market Lawang.
Tiga Aspek Preferensi Pengguna Coworking Space dengan Pendekatan Stated Preference: Desain, Pelayanan, dan Kualitas Lingkungan Ruang Dalam
Authors: Pamela Sofia , Kusuma Hanson E , Safira Annisa
Published: June 2022

The growing number of Coworking Space is one of the phenomena that occurred in the 4.0 industrial era. This is due to changes in work activity model that can be done anywhere with simple devices. The study aims to see the preference of users towards Coworking Space. The research method is qualitative using a grounded theory approach. Data collection was carried out by distributing online questionnaires with open-ended questions and a non-random sampling technique. Data were analyzed using content analysis method, namely open coding. The preference model used is stated preference. The result of the analysis shows that there are three aspects of Coworking Space preferences. They are Design, Service, and Indoor Environmental Quality. The design aspects consist of furniture and interior design, visual comfort, atmosphere, and privacy. Service aspects include facilities, services, accessibility, and social interactions. Indoor environmental Quality is a group of categories of tranquillity, coolness, and health.
Aplikasi Konsep Eco-Culture dalam Pengembangan Kampung Wisata Buah Baran Bercahaya
Authors: Titisari Ema Yunita , Azizah Siti , Kurniawan Syahrul , Ridjal Abraham M , Yuniarti Rahmi
Published: June 2022

The concept of eco-culture has a sustainability paradigm that emphasizes the harmony of humans and ecosystems. The target is the strengthening of local characters through the study of local genius, as well as the application of science and technological innovation in managing the potential for improving the quality of the environment and humans. Increasing the economy through tourism is its added value. Kampung Baran has a unique ethnographic and geographical setting inhabited mostly by low-income people. The potential that can be developed is agriculture which is now slowly starting to be abandoned. This study examines the application of the eco-culture concept which consists of an image of space, an image of building, and an idealized concept of place for the development of Kampung Baran. Through a descriptive-phenomenological study, the researcher explores the physical-spatial-architectural and economic-social-cultural phenomena of Kampung Baran as the object of study. Furthermore, the study of the application of the concept of eco-culture in the village of Baran was carried out through a SWOT analysis. The results obtained indicate that the concept of eco-culture can be applied in Kampung Baran by emphasizing on strengthening the noble values of the culture of agrarian communities in the expression of tangible and intangible heritage that is adaptive to cultural dynamics and strengthening and developing local potential.
Shape Grammar for House Facade along the Alley in Urban Kampung, Tambora, Jakarta
Authors: Desiyana Irma
Published: June 2022

The shape grammar can reveal the socio-spatial uniqueness that moulds the geometric shapes and elements of the house facade in a dense area of the urban kampung. The façade tends to not have the exact pattern due to adjustment of daily activities and needs in Tambora Jakarta. However, the grassroots have formed the pattern of events along the alley that represents contexts like milieu, economics, and social conditions. The alley has overlapping layers between private and public activities, which contribute to the geometric shapes and elements of the façade in Tambora. The house facade depicts activities and relationships inside and outside that manifest in geometric shapes and elements of the facade. Hereafter, this research combines the shape grammar for the geometric pattern of the facade and the pattern language for the qualitative contexts. The first step is categorising the geometric shapes and elements of the facade and the socio-spatial aspects into defined shape rules. Then, mapping the pattern language of activities and needs between inside–house program and outside–the use of space along the alley to delineate spatial relation. The result intends to comprehend the correlation between the logic of the geometric shape and facade elements concerning the qualitative context.
Nilai Signifikansi Budaya Bangunan Lama di Kawasan Alun-Alun Merdeka Kota Malang Berdasarkan Persepsi Masyarakat
Authors: Widiana Fenny , Santosa Herry , Ernawati Jenny
Published: June 2022

Historic buildings that still survive for a long time can affect the image of an area. To study this, this research identified people's perceptions of historical buildings in the Merdeka Square area of Malang. This study used multiple rating scales measuring instruments and photos of eight historic buildings around the Merdeka Square, Malang City as stimuli to investigate the similarities and differences in perceptions between three groups of respondents: the general public, professionals in the field of Architecture (lecturers and students majoring in Architecture, and members of the Indonesian Architectural Association), and the Government (Bappeda, Culture and Tourism Department, and Malang City DPUPR). The results of this study indicated that the order of the most influential cultural significance factors in shaping the image of the Merdeka Square area of Malang is the intangible value and the visual quality of the facade of the old building. It was also found that there were differences in assessment between groups of respondents in assessing the visual quality of the building facade in its effect on the image of the area.
Connectivity dan Integrity dalam Space Syntax pada Bangunan Sekolah Al-Biruni Cerdas Mulia Bandung
Authors: Permata Dian Duhita , Al-Fitriani Egalita Nur , Andriana Febri Ayu , Kurniawan Anggia Nurfadilah
Published: June 2022

Learning activities not only use a single classroom however classrooms, laboratories, libraries, etc. Therefore, the relationship between spaces in the school building needs to be concern so that communication and interaction between students and teachers can be conducted smoothly. The research tended to verify the connectivity and integrity of space syntax in the Al-Biruni Cerdas Mulia school building located in the Bumi Panyileukan Complex, Bandung, West Java. Two different levels of education degree were conducted in the building by sharing the room facilities. The analysis method used the depthmapX v.055 software to see the connectivity and the calculation of integrity values in the forms of total depth, average depth, and relative asymmetry. Testing the program and calculating the values resulted in 21 effective rooms on the first floor and 11 ineffective rooms on the second floor of the school building. Through the theory of syntax space, the problems regarding the spatial arrangement, layout, and circulation in buildings could be resolved, and communication and interaction between students and teachers could be more effective.
Proposals for development of a reference method for measuring lateral forces
Authors: Brzhezovskiy A. M.
Published: June 2022

Introduction. The article considers the prerequisites for choosing the most expedient reference method of experimental determination (measurement) of the lateral (horizontal transverse) force acting in the contact zone of the wheel and the rail head in relation to the procedure for establishing the conditions for the circulation of rolling stock on the railway network. This is one of the important force factors of the interaction of the rolling stock with the elements of the permanent way of the railway track. The author presents a set of methods for experimental evaluation of lateral forces based on the measurement of rail deformations, which were applied in the works of certified testing centres for railway equipment in Russia and the Commonwealth states.

Materials and methods. Based on a set of known experimental techniques, the author proposed to take statistical estimates of the measurement error established by the current interstate regulations as criteria for the validity of the choice of a refe rence measurement technique. Determination of the reference measurement technique involves conducting purposeful experiments with similar conditions, including the types of rolling stock under test, the parameters of the device and structure of the permanent way of the measured section, meteorological parameters, etc. The author has applied the procedures that include the choice and justification of the reference value of the measured indicator, comparison of statistical estimates of the measurement error of lateral forces along with the requirements imposed on the conditions for conducting experiments in accordance with the requirements of regulatory documents of Rosstandart.

Results. As a result, the author described the methods for statistical processing of experimental information of various considered techniques for measuring lateral forces, which enabled to justify the choice of the reference measurement technique.

Discussion and conclusion. The presented method for determining the reference method for measuring the lateral forces of the impact of the wheel on the rail head according to the deformations of the rail considers the requirements of the regulatory documents of Rosstandart and can be used in the experimental evaluation of interaction indicators in the mechanical wheel — rail system.
Redistribution of tractive force per axle for electric locomotives with asynchronous traction motors
Authors: Shilin N. D. , Prokof'ev S. N.
Published: June 2022

Introduction. Improving the traction and adhesion properties of freight electric locomotives is currently an urgent issue for the domestic locomotive industry. The increase in the mass and speed of trains enables to seek new ways and possibilities for realising the maximum tractive force of freight locomotives in order to meet the requirements of the rapidly developing transportation methods.

Materials and methods. The authors carries out the analysis of existing theoretical and practical methods of adhesion control and developed the algorithm for controlling the wheelsets adhesion of a locomotive with asynchronous traction motors.

Results. The authors concerning the tests analysis of a real electric locomotive, developed a mathematical model of the locomotive movement, which included algorithms for axial control of the tractive force with the redistribution of the tractive force between the axles. Calculations of a mathematical model of the movement of a locomotive with a train on a section with the redistribution algorithm both enabled and disabled, as well as with various settings of this algorithm, were carried out. The model also took into account the change in the adhesion coefficient of the wheels with the rails depending on the numerical order of a wheelset in the direction of travel, as well as the additional loading and unloading forces that arise in the undercarriage depending on the tractive force being realised. As a result of the calculations, obtained data showed good convergence with the test data of a real electric locomotive.

Discussion and conclusion. The developed mathematical model allows evaluating the realisation of the tractive force of a locomotive as close as possible to that specified by the locomotive throttle under conditions of a changing adhesion coefficient and its heterogeneity under different wheelsets of the locomotive. The obtained results can be further applied in the development of promising freight electric locomotives with asynchronous traction motors.
Hac Yolunda Bir Bâbür Prensesi / A Mughal Princes on the Road to Haj
Authors: Karakuş Nadir
Published: June 2022

1526’da Hindistan’da kurulan üçüncü büyük Türk Sultanlığı Bâbürlüler, yetiştirdikleri hanedan hanımları ile de ön plana çıkmışlardı. Kitap telif edecek kadar kabiliyetli, şiir yazacak kadar duygu dünyası geniş olan bu hanımlar içinde dönemin en önde tasavvufî hareketi olan Çiştilik yoluna intisap edenler dahi çıkmıştı. Şâir, müellife ve kitap sahibi kişiliği ile ön plana çıkan Bâbür Şah’ın kızı ise daha farklı özellikleri ile de karşımıza çıkar. Gülbeden ismi ile anılan bu Bâbürlü Hanım, abisi Hümâyun Şah’ın zorlu geçen ve on beş yıl kesintiye uğrayan iktidar mücadelesinde ona destek olmaya çalışmıştı. Onun ölümü ile aynı desteği yeğeni Ekber Şah’a da gösteren Gülbeden Begüm, bu süreçte Bâbür İmparatoru’nun içine saplandığı sapkın dinî yönelişlerde de ona çıkış kapıları aralamaya çalışmıştı. Bunun için düzenlenen renkli ve kalabalık bir hac yolculuğunun içinde yer alan Gülbeden, Gucerât sahillerinden Cidde’ye oradan da Mekke’ye ulaşmıştı. Dönüş yolu sancılı olmuş, Aden’de bindikleri geminin batması ile Osmanlı idaresindeki bu şehirde yaklaşık bir yıl geçirmişti. Bu olaylar zinciri Gülbeden Begüm ve diğer Bâbürlü hanedan hanımları ile Osmanlı saray hanımlarının mukayesesini ortaya çıkarmıştı. Osmanlılarda aynı tarihlerde padişah hanımları devlet yönetiminde etkili olup, sultanları zor durumda bırakmış, Bâbür hanımları ise daha çok kültürel ve sosyal faaliyetlerle hayatlarını sürdürmüşlerdi. Haliyle bu makalede her iki devletin de bu açılardan mukayese edilmesi incelenmiştir.
Modern Dönemde Kur'an'ın Temel Konularından Biri Olarak Kadın Hakları: Mısır ve Reşîd Rızâ Üzerinden Bir Değerlendirme / Women’s Rights as One of the Fundamental Issues of The Qur’an in the Modern Period: An Evaluation of Egypt and Rashid Rida
Authors: Külünkoğlu Gülnur
Published: June 2022

Modernleşme ile İslam dünyasında kadın ile ilgili meseleler, önceki dönemlere göre daha yoğun bir vurguyla gündeme gelmiştir. Mesele, genel olarak İslam’da kadının hakları ve Müslüman kadının modern dünyadaki konumu ile irtibatlı olarak tartışılmıştır. Bu dönemde Batı’dan gelen eleştirilerde doğu insanının İslam kaynaklarının etkisinden kurtarılması gerektiği iddia edilmiştir. Modern İslam düşünürleri, problemin İslam’ın temel kaynaklarında olmadığı, İslam’ın yorumlanma biçiminde olduğu üzerinden eleştirilere cevap vermiştir. Bu dönemde Mısır, siyasi, kültürel ve eğitimle ilgili ıslah faaliyetlerinin merkezi olmasının yanı sıra kadın konusundaki ıslah fikirlerinin öncüsü olan isimler bakımından velûd bir coğrafyadır. Mısır bölgesinin önemli isimlerinden olan Muhammed Abduh ve öğrencilerinin İslam’ın kadın haklarını kısıtlamadığını Batı karşısında ispatlama çabasında önemli bir rolü olduğu görülmektedir. Reşîd Rızâ ise Abduh’un en önemli takipçisi olmakla öne çıkmaktadır. Bu bakımdan modernleşme döneminde kadın hakları meselesinin Reşîd Rızâ’nın görüşleri çerçevesinde ele alınması önem taşımaktadır. Çalışmada Rızâ’nın kadın hakları konusundaki görüşlerinin hangi bağlamda ve hangi saiklerle ortaya çıktığı sorusuna cevap aranmıştır. Bu araştırma sorusundan hareketle modern bağlamın etkisi göz önünde bulundurularak Rızâ’nın kadın hakları konusundaki fikirleri analiz edilmiştir. Bu analiz sonucunda Rızâ’nın konu hakkındaki görüşlerinin modernleşme bağlamında yaşanan gelişmelerin ve İslam’da kadın hakları konusunda Batı’dan gelen eleştirilerin etkisiyle şekillendiği görülmektedir. Bu çerçevede çalışmada Rızâ’nın kadın hakları konusundaki görüşleri ortaya konulacaktır. Çalışmanın modern İslam düşünürlerinin önemli isimlerinden olan Reşîd Rızâ’nın kadın hakları konusundaki söyleminin aydınlatılmasına katkı sunacağı düşünülmektedir.
Otel İşletmelerinde Karşılaşılan Fiziksel Sorunların Örgütsel Bağlılık ve İş Tatmini Üzerindeki Etkisi: Kadın Çalışanlar Üzerine Bir Araştırma / The Effect of Physical Problems Encountered in Hotels on Organizational Commitment and Job Satisfaction: A Study on Female Employees
Authors: Demirdağ Şerif Ahmet
Published: June 2022

Özellikle az gelişmiş veya gelişmekte olan ülkelerdeki mevcut kültür yapılarına bağlı olarak, kadın çalışanların iş yaşamında erkeklere oranla dezavantajlı olduğunu belirtmek mümkündür. Kadınların çalışmasına ya da yükselmesine çok ılımlı yaklaşmayan bu kültürlerde yer alan sabit ya da geleneksel fikirler bu kanıyı destekler niteliktedir. Diğer taraftan, bir hizmet sektörü niteliğinde olan turizm sektöründe de kadın çalışanların cinsiyet açısından karşılaştığı birtakım sorunlar yer almakta olup, bu sorunlar çalışanların farklı örgütsel davranışları üzerinde etkili olabilmektedir. Buradan hareketle, bu araştırmanın amacı otel işletmelerinde çalışan kadınların işyerinde karşılaştığı fiziksel sorunların örgütsel bağlılıkları ve iş tatmin düzeyleri üzerindeki etkisini belirlemektir. Araştırmanın amacı doğrultusunda veri toplama aracı olarak anket tekniğinden yararlanılmış olup, Muğla ilinin Fethiye ilçesinde faaliyet gösteren otel işletmelerinden toplamda 398 kullanılabilir anket elde edilmiştir. Veri toplama ve kullanma sürecine ilişkin 01.12.2021 tarihinde etik kurulu onayı (17/3, E-50288587-050.01.04-59915) alınmıştır. Verilerin analizinden elde edilen bulgulara göre, kadın çalışanların işyerinde karşılaştıkları fiziksel sorunlar ile örgütsel bağlılıkları arasında kuvvetli ve negatif yönlü; fiziksel sorunlar ile iş tatmin düzeyleri arasında ise anlamlı zayıf ilişkiler tespit edilmiştir.
Lezers aan het woord
Authors: Redactie GT
Published: June 2022

Muurkapelletje Veergrep. Hotels, publiek of particulier. Van Laemmle’s Theatre (1913) tot Fewa restaurant en tapasbar (2019). Begraven in de Sint-Niklaaskerk (1717). Gent op het Zuidpoolcontinent. Militair domein De Sterre. Metselaarshuis. Seske(n)s. Emma Housmans.
Lezers aan het woord
Authors: Redactie GT
Published: June 2022

Katrienspekken. Seskens en Vier in den buik. Geen Mannekis Pis in het stadhuis.
Soldaat Marie
Authors: Van Hecke Katrien
Published: June 2022

Wederwoord van de auteur Van Hecke op d artikelen over Marie Schellinck in Ghendtsche Tydinghen
De Kuip van Gent: helemaal geen kuip
Authors: Devriese Luc
Published: June 2022

Het Gentse stadscentrum lijkt in niets op een kuip, wel integendeel. De stad dankt zijn ontstaan immers aan de kleine heuveltjes, de Blandijnberg en de Zandberg, die stadsgroei mogelijk maakten in een uitgestrekt overstromingsgebied van twee rivieren. Het is voor een stad als Gent dus geen historische naam. Een aannemelijke hypothese zoekt de oorsprong van de naam bij de Brabantse steden
Vanwaar de naam Graslei?
Authors: Devriese Luc
Published: June 2022

In middeleeuwse teksten werd geen onderscheid gemaakt tussen de Korenmarkt, de Graslei en de Korenlei: ze werden allen als Korenaard aangeduid.
Portretten van lachende vrouwen: door Achilles De Maertelaere (Bentos)
Authors: Bourgeois Jean
Published: June 2022

Hoewel hij nooit getrouwd was en, voor zover wij weten, nooit een relatie had, schilderde Achilles De Maertelaere, alias Bentos, veel portretten van vrouwen. Sommige van die portretten behoren tot zijn meest expressieve werken.
Lezers aan het woord
Authors: Redactie GT
Published: June 2022

Hof van Raveschoot. Seskens. Gentse wijk in Merksplas.
Felix Pyat bezoekt Gent, 1836.
Authors: De Vleeschouwer Herbert
Published: June 2022

Félix Pyat (1810-1889, afb. 1), Frans journalist, toneelauteur en politiek activist, hevig tegenstander van koningschap en keizerrijk, zeker van de latere Napoleon III, tot twee keer toe verbannen uit zijn land, brengt in onderstaand vertaald artikel uit het begin van zijn carrière (1836) een beschrijving van vooral de Gentse kunstverzamelingen in privébezit. De lofbetuigingen aan Gent en ons landje laten we ons - uiteraard - welgevallen. Idem de verandering van nationaliteit bij Rembrandt. De overdreven lofuitingen en de gezwollen taal nemen we op de koop toe.
Fluorescentie-geleide chirurgie voor de resectie van caniene tumoren: een vergelijkende literatuurstudie tussen twee potentiële doelwitproteïnen
Authors: Joos L. , Favril S. , de Rooster H.
Published: June 2022

Na chirurgische resectie van een solide tumor bij honden en mensen is lokaal recidief een belangrijk risico. De klassieke technieken voor visuele inspectie, palpatie en de bepaling van intraoperatieve tumormarges zijn weinig nauwkeurig. Fluorescentie-geleide chirurgie kan een belangrijke rol spelen in de oncologische chirurgie. Tumor-specifieke liganden, gekoppeld aan een fluorescente stof, kunnen tumorcellen op een accurate manier aankleuren door te binden aan hun doelwitproteïne, en daardoor de kans op volledige chirurgische verwijdering van de tumor verhogen. In deze literatuurstudie werd een vergelijking gemaakt tussen twee potentieel interes sante doelwitproteïnen voor gebruik bij fluorescentie-geleide oncologische chirurgie in de dierge neeskunde, zijnde cycline D1 en “epidermal growth factor receptor” (EGFR). Het voornaamste evaluatiecriterium is tumorspecificiteit, waarbij er hoge expressie is in het tumorweefsel en wei nig tot geen expressie in het omliggende, gezonde weefsel. Ook de bereikbaarheid van het pro teïne voor de ligand, waarbij expressie op de celmembraan de voorkeur geniet ten opzichte van intracellullaire expressie, is een evaluatiecriterium. Door zijn betere beschikbaarheid en betere specificiteit lijkt EGFR meer aangewezen voor fluorescentie-geleide oncologische chirurgie bij honden dan cycline D1. Door de grote diversiteit in eiwitexpressie tussen verschillende tumoren is het echter belangrijk om resultaten inzake toepasbaarheid niet te veralgemenen voor andere types tumoren. Hoewel studies en toepassingen uit de humane geneeskunde richtinggevend kun nen zijn voor toepassingen in de diergeneeskunde, mogen onderzoeksresultaten niet rechtstreeks vertaald worden naar andere species.
LA COLECCIÓN HIMENOPTEROLÓGICA (INSECTA) DEL MUSEO DE ZOOLOGÍA “ALFONSO L. HERRERA” DE LA FACULTAD DE CIENCIAS, UNAM, MÉXICO
Authors: Yáñez-Ordóñez Olivia , Hinojosa-Díaz Ismael
Published: June 2022

La colección Himenopterológica del Museo de Zoología “Alfonso L. Herrera” de la Facultad de Ciencias de la UNAM, cuenta con una base de datos que incluye 22,015 ejemplares de abejas correspondientes a seis familias, 115 géneros y 819 especies y subespecies provenientes de 22 entidades federativas del país y áreas con 21 tipos de vegetación, lo que la coloca como la segunda colección en importancia para este grupo de insectos en México.
Mariposas bioindicadoras ecológicas en México. Artículo de revisión
Authors: Orta S. Carolina , Reyes-Agüero Juan Antonio , Luis-Martínez Moisés Armando , Muñoz-Robles Carlos Alfonso , Méndez C. Heriberto
Published: June 2022

En México se han descrito cerca de 1,900 especies de la superfamilia Papilionoidea (sensu lato), que incluye a todos los lepidópteros diurnos en el país (Llorente-Bousquets et al., 2014). Las mariposas diurnas se reconocen como un taxon ampliamente estudiado y se pueden utilizar como bioindicadoras ecológicas. Este artículo de revisión compila la información al respecto en México, identificando 58 artículos y documentos de investigación que mencionan especies indicadoras, aunque solo en 16 de ellos utilizan métodos estadísticos, en su mayoría multivariados para identificarlas como bioindicadoras ecológicas. La información de 179 especies bioindicadoras fue compilada en dos anexos, destacando las principales características que facilitan su búsqueda en campo, como tipo de vegetación, hábitos alimentarios, fenología y grado de especialización. De las 179 especies, 55 se caracterizaron para áreas conservadas, 99 en áreas con disturbio y 25 en ambas condiciones. Se anexa una lista de plantas huésped en el país para 116 especies de mariposas diurnas de las 179 identificadas, con la finalidad de facilitar su asociación con la comunidad vegetal y sus interacciones. Por último, se emiten recomendaciones para el diseño de un muestreo que permita utilizar a estas especies bioindicadoras como objeto de estudio en proyectos de monitoreo ambiental a mediano plazo.
Fauna de Carabidae (Insecta: Coleoptera) del Estado de Hidalgo, México: Lista de especies, primeros registros y datos de distribución geográfica
Authors: Cerón-Gómez Rafael , Márquez Juan , Ramírez-Ponce Andrés
Published: June 2022

Se presenta una síntesis de la riqueza de especies y distribución geográfica de escarabajos carábidos del estado de Hidalgo, México, elaborada mediante la revisión de ejemplares de tres colecciones nacionales y una extrajera, revisión exhaustiva de literatura publicada, incluyendo dos trabajos de tesis, y la revisión de bases de datos de cuatro colecciones entomológicas. Se reconocen 134 especies de carábidos (incluyendo cinco morfoespecies) clasificadas en nueve subfamilias, 26 tribus y 52 géneros, de las cuales 50 son primeros registros estatales; además, se presentan nuevos datos de distribución dentro del estado para 10 especies. El 39.5 % del total de especies tienen una distribución restringida a México. El municipio que registra el mayor número de especies es Zimapán. La mayor proporción de especies se presenta en los bosques de pino y pino-encino, y en elevaciones por encima de los 2,000 m. La provincia biogeográfica con el mayor número de especies es la Sierra Madre Oriental; sin embargo, se requiere de más muestreos en otras zonas importantes del estado. Este trabajo es el primer inventario de carábidos de la entidad y pretende servir como base para futuros estudios con enfoques taxonómicos, ecológicos, de conservación, y biogeográficos en Hidalgo y en México.
CLINICAL AND EPIDEMIOLOGICAL FEATURES OF THE FACTORS OF ORIGIN MICRO VASCULAR COMPLICATIONS IN PATIENTS WITH TYPE 2 DIABETES MELLITUS
Authors: Gurina N. I.
Published: June 2022

The prevalence and nature of the course of microvascular complications among

1556 patients with type 2 diabetes mellitus. The dependence between age is analyzed,

sex, place of residence, duration of the disease, age of the patient at the manifestation of diabetes, the degree of progression of microvascular complications and their relationship with

the state of compensation of carbohydrate metabolism. It is shown that the frequency of all types of microvascular complications is significantly higher in patients in rural areas. Frequency

microangiopathy for diabetes does not depend on the sex of the patient. Prolonged course of the disease

and its unsatisfactory compensation are important risk factors for the development and progression of complications of diabetes
STUDY OF THE LEVEL OF INTERLEUKIN-8 AND INTERLEUKIN-17 WITH AUTOIMMUNE THYROIDITIS
Authors: Prylutsky O. S. , Kasyarum V. P. , Lesnichenko D. O. , Prylutska O. O. , Piskureva G. V.
Published: June 2022

The levels of interleukins-8 and -17 in autoimmune thyroiditis were studied. Probably elevated concentrations of test cytokines were combined with elevated levels of specific autoantibodies to thyroglobulin and thyroperoxidase in patients

with a confirmed diagnosis of the disease. Positive correlative is established relationship between interleukins-8 and -17. Analysis of the obtained data confirms the direct participation and pathogenetic significance of the studied cytokines in the development

and disease progression
THE CHANGES IN ADOLESCENTS THYROID STATUS WITH DIFFUSE NONTOXIC GOITER ON THE STAGES OF SEXUAL MATURATION
Authors: Turchina S. I.
Published: June 2022

The study of thyroid status in adolescents of 10-17 years old with diffuse nontoxic goiter allowed to determine of sex differences in rates of thyroid profile in adolescents with different levels of pubertal development. The period of early puberty in girls is characterized by a higher rate of TTG and in boys it is characterized by a decrease in the concentration of free thyroxine. The signs of minimal thyroid insufficiency and subclinical hypothyroidism can be registered more often in boys with diffuse nontoxic goiter of senior age than in menstruating girls what can be evidenced by the marked reduction of the integral rate of the thyroid with increased rate of TTG/fT4.
HYPOLIPIDEMIC AND PLEYOTROPE EFFECTS OF ATORVASTATINE IN WOMEN WITH AUTOIMUNE THYREOIDITE
Authors: Goncharova Olga , Ilyina I. M. , Holodny A. V.
Published: June 2022

Lipide, immune and thyreoid statuse in women with autoimmune thyreoidite were studied before, after two month taking of atorvastatin in dose 10 mg/day on the background of adequate thyroid therapy, wich was earlier regulated. It was revealed, that in addition to positive effect on lipide homeostas, atorvastatin have been decreased expression of hypothyreos, corrected cellular link of immune reply. After six months after treatment the pleyotrope effect has been maintained, but lipid homeostasis returned to initial status.
Comparison assessment of the potential radiation hazard of tailing dumps in the Sughd region of Tajikistan
Authors:   Nuclear and Radiation Safety Agency of National Academy of Sciences of Tajikistan, Mirsaidov U.M. , Nazarov Kh.M. ,   Nuclear and Radiation Safety Agency of National Academy of Sciences of Tajikistan, Makhmudova M.M. ,   Avicenna Tajik State Medical University, Murodov Sh.R. ,   Nuclear and Radiation Safety Agency of National Academy of Sciences of Tajikistan, Ermatov K.A. ,   Nuclear and Radiation Safety Agency of National Academy of Sciences of Tajikistan, Akhmedov M.Z. ,   Nuclear and Radiation Safety Agency of National Academy of Sciences of Tajikistan
Published: June 2022

The global environmental changes have been observed since the nineties of the twentieth centu-ry. The current environmental situation is caused mainly due to the intensive human activity. Dur-ing 46 years, from 1945 to 1991, radioactive waste from uranium processing was accumulated in the Sughd region in Tajikistan, the former USSR Republic. According to various estimates the to-tal amount of accumulated radioactivity varies from 240 to 285 TBq. The tailings are the major sources of environmental pollution, they contain emanating gas, aerosols, dust and filterable solutions. The purpose of the work is to conduct comparison assessment of the potential radiation hazard of “Digmai” and “Adrasman” tailing dumps and Istiklol-city in the Sughd region and to estimate radiological risks to the population living near the tailing dumps. For radon monitoring both integral and instantaneous measurements were used. For instant measurements of radon volu-metric activity the PPA-01M-03 LLC “HTM-Protection” (Russia) raidometer was used. The back-ground radiation in the area under study was measured with Dosimeters DKS-96 “Dose” (Rus-sia), DKS-AT1123 “Atomtech” (Belarus), MKS-AT6130 “Atomtech” (Belarus) and PackEye FHT complex-1377 “Thermo” (Germany). The paper presents data on comparison assessment of po-tential hazard of radioactive tailing dumps in the Sughd area. The impact of uranium tailing dumps on radioecological situation in the Sughd region, as well as in cities and districts of the Sughd region was assessed. The most unfavorable radioecological situation in the Sughd region is in areas with the ambient dose equivalent power (MAED)>0.35-0.40 μSv/h. The coordinates of the areas location coincide with coordinates of the radioactive tailing dumps Istiklol-city and Gaziyeon (“Digmai”) location, and their adjacent territories. According to comparison assessment, the tailing dumps “Digmai” and “Factory of Poor Ores” (Istiklol-city) are potentially the most haz-ardous facilities. It means that for radioecological safety of the environment and the population, it is recommended to carry out cleaning and remediation of the tailing dumps as a priority: «Dig-mai» and «Factory of poor ores».
Sixty years of manned space flight in the light of Russian legislation in the field of radiation safety. Basic principles in Russian manned flights. Part 2 (in the order of discussion)
Authors:   Research and Technical Center of Radiation-Chemical Safety and Hygiene of the FMBA of Russia, Sakovich V.A.
Published: June 2022

This article is the second of two interrelated ones, in which, in order to discuss from the point of view the basic principles of ensuring radiation safety, the 60-year evolution of the regulation of radiation safety of space flights (RSSF) and radiation safety in ground conditions is compared. The first article is devoted to the analysis of the implementation of basic principles in the recom-mendations of the ICRP and in Russian legislation. It is recognized that the principles played a positive methodological role, but at present the inclusion of their wording in legal and regulatory documents seems unnecessary to the author. In this article, a detailed analysis of documents regulating the RSSF and the implementation of the basic principles in them is carried out. It is concluded that the concept of risk is more fully used in relation to RSSF and even standards have been adopted for its calculation. It is argued that the arguments proposed to reduce dose limits for near-Earth flights contradict basic principles. The need for such a reduction is denied. It is proposed to carry out the planned changes of FL of RSP and NRS in relation to various conditions and circumstances of exposure, including to allocate RSSF in FL RSP as a special area of regulation.
Radiobiological model for calculating the probability of death of mammalian cells exposed to ionizing radiation with different linear energy transfer
Authors:   Rosenergoatom JSC, Dolgikh A.P. , Pavlik T.I. ,   Prokhorov General Physics Institute of the RAS
Published: June 2022

One of the fundamental problems of radiobiology is to predict a quantitative relationship between the onset of a specified radiation-induced effect on a biological object and the dose of exposure to ionizing radiation under different conditions (for ionizing radiation of different quality and different time of exposure). The purpose of this article is to solve a particular part of the general problem: the development of a mathematical model for the probability of death of mammalian cells depending on the radiation dose with arbitrarily specified linear energy transfer (LET), with a single irradiation of these cells in vitro. To solve this problem, microdosimetric approaches based on the theory of the dual action of radiation were used. When developing the model, the following assumptions were used: 1) there are sensitive volumes (SVs) in the cell, damage to the volumes can lead to cell death; 2) the probability of cell death depends on the number of damaged SVs; 3) the probability of damage to the SVs depends on the energy absorbed in it; 4) to calculate the energy absorbed in the SVs, a simple model for the interaction of ionizing particles with matter was used: the particles move in a straight line, the LET of the particles coincide with the linear energy absorbed in the matter. The developed mathematical model for estimating relationship of the probability of cell death on the dose explicitly contains LET. Thus, the use of the proposed model makes possible separation of biological parameters responsible for the onset of radiation-induced effect from radiation characteristics of the irradiation conditions., Classical radiobiological data, underlying the IAEA ionizing radiation recommendations for determining the relative biological effectiveness (RBE) of different types present an argument for the model validation. Experimental data on irradiation of human kidney T1 cells present an example. The article demonstrates that the developed model makes it possible to calculate the probability of cell death depending on the dose of ionizing radiation with an arbitrarily set LET for photons, electrons, and -particles with a LET from 0.4 to 200 keV/ µm. It follows from the proposed model that a linear-quadratic dependence can occur not only in DNA damage, but also in other biologically important molecules. The use of this model can be extended to predict other radiation-induced effects, as well as the probability of occurrence of radiation-induced effects under various time exposure regimes.