bluuebunny/crossref_metadata_2025 huggingface dataset:
Konflikt und Struktur in der psychoanalytischen Familientherapie
Authors: Dott Peter
Published: November 2023

Ausgangspunkt meiner Überlegungen ist die Zusammenfassung von Möhring und Neraal (2022) zur theoretischen Entwicklung der psychoanalytischen Familientherapie in Deutschland. Sie fokussieren vor allem auf die generationenübergreifende Weitergabe familiärer Konflikte (Massing, Reich und Sperling), die damit verbundenen Rollenerwartungen der Eltern an die Kinder (Richter), familiäre Bindung und Delegation (Stierlin), sowie die in der Beziehungsanalyse Thea Bauriedls konzipierte zwischenmenschliche Beziehungsfähigkeit. Vor dem Hintergrund heutiger empirischer Erkenntnisse wird die Bindungstheorie und die Mentalisierungstheorie dargestellt. Dies soll jedoch keine Abkehr von der Konflikttheorie psychischer Störungen beinhalten. Andererseits bräuchten manche Menschen zunächst ausreichend stabile und verlässliche Zuwendung und Aufmerksamkeit, ehe sie sich konkreten Auseinandersetzungen mit Anderen zuwenden können. Mentalisierungsdefizite sind aber die Folgen von Bindungsproblemen mehr oder minder kleiner oder größerer Traumata.
Consideraciones acerca de la risa dentro de la medicina griega antigua. Corpus Hippocraticum y Galeno
Authors: Rodríguez Moreno Inmaculada
Published: November 2023

El presente artículo analiza todos los testimonios en torno a la risa dentro de la literatura médica griega. Así, las referencias de Hipócrates y Galeno sobre tal manifestación física, sea voluntaria o espontánea, son esenciales para observar su origen, ejecución y vínculo a determinadas patologías, con la finalidad de aportar una visión desde el ámbito de la medicina antigua.
Objects as manifestations of the sacred and the demonic in Dostoevsky’s works
Authors: Kovalevskaya Tatyana Vyacheslavovna
Published: November 2023

The aim of the research is to explicate the specific features of the sacred and the demonic manifesting in objects in a number of Fyodor Dostoevsky’s works and determine the dominant mode of such manifestations thereby providing an explanation of the findings. The novels ‘Crime and Punishment’, ‘The Devils’, and ‘The Brothers Karamazov’ are used to demonstrate that the sacred can manifest in images and icons, crosses, incense bags used to carry relics, books, holy objects. The range of objects manifesting the demonic is far narrower; the demonic mostly manifests in books, dangerous items and, when it comes to living creatures, in certain animals. The research is original in that it inaugurates a comparative study of this matter, highlights the importance of the image in manifesting the sacred and shows that the manifestations of the sacred and the demonic in objects are closely linked with Dostoevsky’s key religious and philosophical ideas. Our findings show that objects manifesting the sacred and the demonic differ in the role played by the image/icon understood in the full spectrum of this word’s meanings. The image takes center stage in manifesting the sacral realm and acts as a force of cohesion amidst the humanity, while manifestation in an image is something that is desirable, but never achievable in the realm of the demonic.
Mykola Markiyanovych Volkovych: surgeon, scientist
Authors: Zavernyi L. G. , Tsiura Y. P. , Stetsenko O. P. , Tarasiuk T. V. , Shulyarenko O. V. , Kryvopustov M. S.
Published: November 2023

The article focuses on the professional and scientific achievements of Professor Mykola Markiyanovych Volkovych, who gained recognition inside and outside the borders of Ukraine. He demonstrated an exceptional level of professionalism as a surgeon, being honoured as one of the founders of Kyiv’s surgical school and earning a distinguished reputation as a scientist. Additionally, he introduced the «Rules for students undergoing training in the hospital surgical clinic», which are still relevant today. He’s the author of nearly 100 works encompassing a wide range of issues within the fields of surgery, traumatology, orthopaedics, otorhinolaryngology, gynaecology, urology, and neurosurgery.
Patient with multifocal pancreatic insulinoma: a rare presentation of functional pancreatic neuroendocrine neoplasm
Authors: Bobrovs E. , Pavulans J. , Konrade I. , Laguns R. , Plaudis H.
Published: November 2023

Insulinoma is a type of neuroendocrine tumour with an incidence of 1—4 cases per million. Multiple insulinomas constitute less than 10% of all insulinomas. Surgery is the treatment of choice for insulinoma. The operation can be done with an open or laparoscopic approach, with cure rates ranging from 77% to 100%. Pancreatic resection is recommended for tumours larger than 2 cm in size, while enucleation is advised for lesions smaller than 2cm if the tumour is at least 2—3 mm away from the main pancreatic duct to prevent the formation of a fistula. For better intraoperative localization of lesions, bimanual palpation together with intraoperative ultrasonography (IOUS) is advised. Palpation alone has 70% sensitivity, but together with IOUS, it reaches 85—95%
A young female patient in her late 20s with non‑specific complaints and a medical history of epilepsy dating back to the age of 17 underwent a physical examination. Blood test results indicated severe hypoglycemia, and magnetic resonance imaging (MRI) revealed an 11‑mm neoplasia in the body of the pancreas. A 72‑hour fasting test confirmed the diagnosis of insulinoma, and the patient underwent laparoscopic surgery. IOUS was done for the precise localization of the lesion, and another tumour in the pancreatic tail was found. A spleen‑preserving laparoscopic distal pancreatectomy was performed. Histologic reports confirmed multifocal Grade 1 insulinoma. The postoperative course was uneventful. After 4 months of follow‑up, computed tomography (CT) was done, and there were no signs of recurrence of insulinoma, pancreatic pseudocysts, or other signs of postoperative complications. Since the operation, the patient has not had any episodes of hypoglycemia or seizures.
The wide spectrum of symptoms, which are not specific to insulinomas, in particular seizures, can make it difficult to establish a correct diagnosis and can be mistaken for other psychiatric or neurologic disorders. This case clearly shows the advantages of IOUS‑guided surgery in achieving better visualization and outcomes. After enucleation of the smaller lesion without the use of IOUS, other insulinomas would be missed and left in place because they were located deeply in the parenchyma. Simple visualization and palpation would not be enough.
Application of cryogenic technologies in complicated cases of surgical treatment of colorectal cancer liver metastases. Case report
Authors: Dronov O. I. , Kozachuk Y. S. , Bakunets Y. P. , Bakunets P. P. , Prytkov F. O. , Yurkin D. Y.
Published: November 2023

Surgical resection is a standard treatment strategy for both primary and secondary malignant liver neoplasms. Liver transplantation is considered the most effective treatment method for colorectal cancer liver metastasis. Palliative debulking liver resection is one of the optimal alternative procedures for patients ineligible for a liver transplant, as it improves overall survival. Resectability rates depend on the functional efficiency of the remaining portion of the liver, which can be improved by increasing the future liver remnant. The application of cryogenic technologies for the ablation of a residual tumour invading the intraparenchymal segments of the major hepatic vessel may have advantages in cases where it is impossible to expand the scope of the surgical intervention due to the insufficiency of the future liver remnant and/or the presence of severe concomitant pathology.
Objective — to present a case report of cryogenic technology application in complicated cases of surgical treatment of patients with colorectal cancer liver metastases.
Case report. The case report presents an experience of cryoablation of the metastasis tissue with invasion into the intraparenchymal portal branch of Sg III, which was revealed during the I stage of the split in situ/ligation of the portal vein (ALPPS) liver resection. Cryoablation was performed by the application method with a single cryocycle and spontaneous thawing. Device — Cryo‑Pulse (Ukraine). Cryoagent — liquid nitrogen (T ‑180...‑196°С). Exposure time was 3 min. The specific complications associated with cryoablation were not observed.
Conclusions. The application of cryogenic technologies for combined debulking surgical treatment of malignant focal liver lesions may be a safe treatment option in cases of residual tumour invasion into portal vein branches. The study is still ongoing.
Breed characteristics of the endobiotic fauna of the domestic reindeer
Authors: Sleptsov E. , Machakhtyrov G. , Machakhtyrova V. , Fedorov V. , Plemyashov K. , Andreyeva M. , Shadrina Ya. , Grigoryev I.
Published: November 2023

Purpose: to study the species diversity of the endobiontic fauna of the domestic reindeer of the Even and Chukchi breeds.

Materials and research methods. There were studied the stomach contents of 69 adult reindeer of two breeds: the Chukchi breed from the Nizhnekolymsky region (40 heads) and the Even breed from the Oymyakonsky region (29 heads). The collection of the proventriculus contents was carried out during the mass slaughter of domestic reindeer in November 2022. The time interval after the slaughter of the deer before sampling was no more than 20-25 minutes. Samples were fixed with 10% formalin solution. The identification of species was carried out according to the determinants of Dogel V.A., 1929; Kornilova O.A., 2003, 2010. Species composition comparison of the endobiont infusoria of the animal fauna of the studied breeds was carried out according to the Jacquard-Malyshev similarity coefficient (Kj-m) and the Czekanowski-Sjørensen fauna commonality index (Ics).

Results. As a result of the research, it was established that the species diversity of the endobiontic fauna of domestic reindeer of the Chukchi and Even breeds is insignificant, but differs. The species composition of endobiontic infusoria was determined on the basis of morphological and morphometric studies. In total, 18 species of infusoria belonging to 9 genera were identified, including 18 species of deer of the Even breed in 9 genera and 13 species of deer of the Chukchi breed in 6 genera. The basis of common species of infusoria for deer of the Chukchi and Even breeds bred in Yakutia is 3 species of Entodinium, 3 species of Epidinium, 2 species of Diplodinium and Ostracodinium, 1 species of Polyplastron, Enoploplastron and Dasytricha. The greater species diversity of endobionts of the Even breed can be explained by the fact that the Even breed belongs to the taiga type with a wider variety of food plants eaten than in the tundra deer of the Chukchi breed.
The influence of the mass of incubation eggs on the growth indicators of a live weight of the bred young chickens and the quality of their eggs
Authors: Fedorova Z. , Vachrameev A.
Published: November 2023

Purpose: to determine the influence of the mass of hatching eggs on the growth and development of hatched chickens and on the quality of the eggs obtained from them in hens of the Pushkin breed.

Materials and methods. The material for the study was chickens of the Pushkin breed, in the amount of 70 heads. 52 weeks of age and their descendants, used later in reproduction (85 ♀ and 28 ♂). The birds were kept in individual cages. Conditions of keeping and feeding are in accordance with the standards adopted in the bioresource collection of the All-Russian Scientific Research Institute of Growing Animals “Genetic collection of rare and endangered breeds of chickens”. Immediately before incubation, 340 eggs were estimated by mass. hatching eggs. The hatched chickens were weighed at the ages of 2, 4, 6, 8, 10, 12 weeks. Depending on the weight of the incubation egg of the mothers and the sex of the chick, the data obtained were divided into three groups: Group I (light) ⩽M-0.5σ (⩽63.7 g-♀ and ⩽65.14 g-♂), Group III ( heavy) ⩾M+0.5σ (⩾68.2 g-♀and ⩾70.07 g-♂), eggs with intermediate weight are classified as “medium” - group II. At the age of 35 weeks, eggs obtained from daughters of the experimental groups were assessed.

Results. It was noted that there are high correlation coefficients between  weight incubation eggs the weight day-old of chickens: for hens r = 0.85 for roosters 0.95 (Р<0,001). The average live weight at one day of age by group differed significantly from each other. Significant differences were observed in both hens and roosters between groups I and III at 2 (P<0.05), 6, 8, 10, and 12 months of age (P<0.01). There were no significant differences in live weight between groups I-II and II-III. In terms of the quality of daughters' eggs, significant differences were observed in the weight of laid eggs between groups I and II, I and III (P < 0.01). In terms of the mass of protein, yolk, shell and the energy value of eggs, the highest indicators were noted in group III.

Conclusion. Studies have shown that the weight of eggs affects not only the live weight of chickens at the daily age, but also the live weight at a later period of growth. The coefficient of heritability of eggs mass (h2) for mothers was 0.701 (P<0.001) and for fathers 0.389 (P<0.01). Thus, it is possible to increase meat productivity without reducing the quality of eggs in meat-egg breeds of chickens by selecting incubation eggs of a larger mass.
Comparative characteristics of female Ladoga palia (Salvelinus Alpinus L.), grown in the conditions of fish farming in the Leningrad region by size, weight and reproductive characteristics
Authors: Berenev Yu.
Published: November 2023

Purpose: to conduct a comparative characterization of females matured for the first time at the age of 4 and 5 years according to the main mass-dimensional and reproductive characteristics.

Materials and methods. Experimental studies were carried on the basis of the Federal Fish Breeding Genetic Center (FSGTSR). The object of the study was female Ladoga char (Salvelinu salpinus L.) of the III generation, which reached puberty at 4- (n=50) and 5-year-olds. (n=45) age. Females of the second generation of factory breeding were individually assessed in two stages: during the first spawning at the age of five years (2019) and in the next spawning season at the age of six years (2020). When measuring the body and collecting genital products, clove oil was used as an anesthetic. Anesthesia was performed by placing the fish in an aqueous solution of clove oil at a concentration of 0,15–0,2 ml/l for 2–3 minutes.

Results. When evaluating mature females at the age of 4 and 5 years, it was found that with a statistically significant increase in body weight of five-year-olds from 1869.3 ± 57.5 to 2156.6 ± 96.53, the multiplicity between the body weight limits did not change with age and is 3 ,2. For other criteria, there is a tendency to decrease in variability. A statistically significant increase in the average weight of one egg is observed, provided that the average values of other reproductive traits do not differ. At the same time, the variability of these signs in five-year-olds is higher than in four-year-olds. So the working fertility increased from 37,4 to 55,1 %, and relative from 26,8 to 43,7 %. Correlation analysis showed the appearance of a weak negative relationship with age between relative fecundity and most of the weight-size traits, otherwise the general trends were preserved in conjunction with an increase in positive correlation.
Exploring Disparities in Healthcare Wearable Use among Cardiovascular Patients: Findings from a National Survey
Authors: Chandrasekaran Ranganathan , Sharma Pratik , Moustakas Evangelos
Published: November 2023

Background: Use of healthcare wearable devices holds significant potential for improving the prevention and management of cardiovascular diseases (CVD). However, we have limited knowledge on the actual use of wearable devices by CVD patients and the key factors associated with their use. This study aims to assess wearable device use and willingness to share health data among CVD patients, while identifying socio-demographic, health, and technology-related factors associated with wearable technology use. Methods: Using a national survey of 933 CVD patients, we assess use of wearable healthcare devices (use, frequency of use and willingness to share health data from wearable with a provider), and a set of socio-demographic factors (age, gender, race, education and household income), health-related variables (general health, presence of comorbid conditions: diabetes and high blood pressure, attitude towards exercise) and technology self-efficacy using logistic regression. Results: Of the 933 CVD patients, 18.34% reported using a healthcare wearable device in the prior 12 months. Of those, 41.92% indicated using it every day and another 19.76% indicated using it ‘almost every day’. 83.54% of wearable users indicated their willingness to share health data with their healthcare providers. Female CVD patients are more likely to use wearables compared to men (odds ratio (OR) = 1.65, 95% confidence interval (CI) = 1.04–2.63). The odds decrease with age, and are significantly high in patients with higher income levels. In comparison with non-Hispanic White, Hispanic (OR = 0.14, 95% CI = 0.03–0.70) and African Americans (OR = 0.17, 95% CI = 0.04–0.86) are less likely to use healthcare wearables. CVD patients who perceive their general health to be better (OR = 1.45, 95% CI = 1.11–1.89) and those who enjoy exercising (OR = 1.76, 95% CI = 1.22–2.55) are more likely to use wearables. CVD patients who use the internet for searching for medical information (OR = 2.10, 95% CI = 1.17–3.77) and those who use electronic means to make appointments with their providers (OR = 2.35, 95% CI = 1.48–3.74) are more inclined to use wearables. Conclusions: Addressing low wearable device usage among CVD patients requires targeted policy interventions to ensure equitable access. Variations in gender, age, race/ethnicity, and income levels emphasize the need for tailored strategies. Technological self-efficacy, positive health perceptions, and exercise enjoyment play significant roles in promoting wearable use. These insights should guide healthcare leaders in designing effective strategies for integrating wearables into cardiovascular care.
An Accessible Pre-Rehabilitation Bundle for Patients Undergoing Elective Heart Valve Surgery with Limited Resources: The TIME Randomized Clinical Trial
Authors: Luo Zeruxin , Zhang Xiu , Wang Yuqiang , Huang Wei , Chen Miao , Yang Mengxuan , Yu Pengming
Published: November 2023

Background: Despite gradually increasing evidence for pre-rehabilitation for heart valve surgery, it remains underused, especially in developing countries with limited resources. The study aimed to investigate the feasibility and effects of an innovative three-day pre-rehabilitation bundle for patients undergoing elective heart valve surgery. Methods: This was a single-center, assessor-blind, randomized clinical trial. A total of 165 patients were randomly assigned to either usual care (control group, n = 83) or usual care with an additional 3-day pre-rehabilitation bundle (Three-day of Inspiratory muscle training, aerobic Muscle training, and Education (TIME) group, n = 82). The main outcome of the study was the incidence of postoperative pulmonary complications (PPCs). Secondary outcomes included the feasibility of the intervention, duration of the non-invasive ventilator, length of stay, and PPCs-related medical costs on discharge. Results: Of 165 patients 53.94% were male, the mean age was 63.41 years, and PPCs were present in 26 of 82 patients in the TIME group and 44 of 83 in the control group (odds ratio (OR), 0.60; 95% CI, 0.41–0.87, p = 0.006). The feasibility of the pre-rehabilitation bundle was good, and no adverse events were observed. Treatment satisfaction and motivation scored on 10-point scales, were 9.1 ± 0.8 and 8.6 ± 1.4, respectively. The TIME group also had fewer additional PPCs-related medical costs compared to the control group (6.96 vs. 9.57 thousand CNY (1.01 vs. 1.39 thousand USD), p < 0.001). Conclusions: The three-day accessible pre-rehabilitation bundle reduces the incidence of PPCs, length of stay, and PPCs-related medical costs in patients undergoing elective valve surgery. It may provide an accessible model for the expansion of pre-rehabilitation in countries and regions with limited medical resources. Clinical Trial Registration: This trial was based on the Consolidated Standards of Reporting Trials (CONSORT) guidelines. This trial was registered in the Chinese Clinical Trial Registry (identifier ChiCTR2000039671).
Pectus Excavatum and Risk of Right Ventricular Failure in Left Ventricular Assist Device Patients
Authors: Zijderhand Casper F. , Yalcin Yunus C. , Sjatskig Jelena , Bos Daniel , Constantinescu Alina A. , Manintveld Olivier C. , Birim Ozcan , Bekkers Jos A. , Bogers Ad J. J. C. , Caliskan Kadir
Published: November 2023

Background: Right ventricular failure (RVF) is a significant cause of morbidity and mortality in patients with a left ventricular assist device (LVAD). This study is aimed to investigate the influence of a pectus excavatum on early and late outcomes, specifically RVF, following LVAD implantation. Methods: A retrospective study was performed, that included patients with a HeartMate 3 LVAD at our tertiary referral center. The Haller index (HI) was calculated using computed tomography (CT) scan to evaluate the chest-wall dimensions. Results: In total, 80 patients (median age 57 years) were included. Two cohorts were identified: 28 patients (35%) with a normal chest wall (HI <2.0) and 52 patients (65%) with pectus excavatum (HI 2.0–3.2), with a mean follow-up time of 28 months. Early (≤30 days) RVF and early acute kidney injury events did not differ between cohorts. Overall survival did not differ between cohorts with a hazard ratio (HR) of 0.47 (95% confidence interval (CI): 0.19–1.19, p = 0.113). Late (>30 days) recurrent readmission for RVF occurred more often in patients with pectus excavatum (p = 0.008). The onset of late RVF started around 18 months after implantation and increased thereafter in the overall study cohort. Conclusions: Pectus excavatum is observed frequently in patients with a LVAD implantation. These patients have an increased rate of readmissions and late RVF. Further investigation is required to explore the extent and severity of chest-wall abnormalities on the risk of RVF.
Clinical and Prognostic Value of Non-Fasting Lipoproteins and Apolipoproteins in Chinese Patients with Coronary Heart Disease
Authors: Zhang Junfeng , Tang Zhengde , Jiang Jintong , Huang Shuying , Zeng Huasu , Gu Jun , Wang Changqian , Zhang Huili
Published: November 2023

Background: Lipid profiles differ naturally between individuals and between populations. So far, the data relating to non-fasting lipid profiles has been derived predominantly from studies on Western population. The characteristics and clinical significance of non-fasting lipids in Chinese patients with coronary heart disease (CHD) in response to traditional Chinese diets remain poorly understood. Methods: A total of 1022 Chinese CHD patients with coronary artery luminal stenosis >40% as diagnosed by coronary artery angiography were enrolled in the study. All patients received standard treatment for CHD, including statins. They were divided into an intermediate stenosis group (luminal stenosis 40–70%, n = 486) or a severe stenosis group (luminal stenosis >70%, n = 536). Their blood lipid profiles were measured in the fasting state, and 4 hours after normal breakfast. All participants were followed up for five years. Major adverse cardiovascular events (MACE) including all-cause death, cardiac death, myocardial infarction, unscheduled coronary revascularization and stroke were recorded. Results: After normal breakfast intake, patients with intermediate or severe stenosis showed an apparent increase in the levels of triglyceride (TG), remnant cholesterol (RC) and Apo (apolipoprotein) A1 compared to the fasting state, but a significant reduction in the levels of total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), non-high-density lipoprotein cholesterol (non-HDL-C), Apo B and Apo E. In addition to the traditional risk factors (older age, male, diabetes and smoking) and coronary artery stenosis, the fasting levels of LDL-C and Apo B, as well as non-fasting levels of HDL-C and Apo A1, were identified as independent predictors of 5-year MACE occurrence by multivariate Cox proportional hazards analysis. Patients in the 1st tertile of the non-fasting HDL-C group (<0.86 mmol/L) showed a significantly higher risk of MACE than 3rd tertile (>1.07 mmol/L) (1st tertile: 2.786, 95% CI (confidence intervals) [1.808, 4.293], p < 0.001). Conclusions: This prospective observational study found that lipid profiles in either the fasting or non-fasting states were associated with the long-term risk of MACE in Chinese CHD patients. In addition to the fasting LDL-C level, a low non-fasting HDL-C level may also be an independent risk factors for cardiovascular events. Measurement of lipid profiles during the non-fasting state may be feasible for the management of CHD patients in routine clinical practice in China.
Predictive Value of Machine Learning for Recurrence of Atrial Fibrillation after Catheter Ablation: A Systematic Review and Meta-Analysis
Authors: Fan Xingman , Li Yanyan , He Qiongyi , Wang Meng , Lan Xiaohua , Zhang Kaijie , Ma Chenyue , Zhang Haitao
Published: November 2023

Background: Accurate detection of atrial fibrillation (AF) recurrence after catheter ablation is crucial. In this study, we aimed to conduct a systematic review of machine-learning-based recurrence detection in the relevant literature. Methods: We conducted a comprehensive search of PubMed, Embase, Cochrane, and Web of Science databases from 1980 to December 31, 2022 to identify studies on prediction models for AF recurrence risk after catheter ablation. We used the prediction model risk of bias assessment tool (PROBAST) to assess the risk of bias, and R4.2.0 for meta-analysis, with subgroup analysis based on model type. Results: After screening, 40 papers were eligible for synthesis. The pooled concordance index (C-index) in the training set was 0.760 (95% confidence interval [CI] 0.739 to 0.781), the sensitivity was 0.74 (95% CI 0.69 to 0.77), and the specificity was 0.76 (95% CI 0.72 to 0.80). The combined C-index in the validation set was 0.787 (95% CI 0.752 to 0.821), the sensitivity was 0.78 (95% CI 0.73 to 0.83), and the specificity was 0.75 (95% CI 0.65 to 0.82). The subgroup analysis revealed no significant difference in the pooled C-index between models constructed based on radiomics features and those based on clinical characteristics. However, radiomics based showed a slightly higher sensitivity (training set: 0.82 vs. 0.71, validation set: 0.83 vs. 0.73). Logistic regression, one of the most common machine learning (ML) methods, exhibited an overall pooled C-index of 0.785 and 0.804 in the training and validation sets, respectively. The Convolutional Neural Networks (CNN) models outperformed these results with an overall pooled C-index of 0.862 and 0.861. Age, radiomics features, left atrial diameter, AF type, and AF duration were identified as the key modeling variables. Conclusions: ML has demonstrated excellent performance in predicting AF recurrence after catheter ablation. Logistic regression (LR) being the most widely used ML algorithm for predicting AF recurrence, also showed high accuracy. The development of risk prediction nomograms for wide application is warranted.
The Prognostic Significance of Secondary Mitral Regurgitation in Heart Failure Patients with Varying Estimated Pulmonary Artery Systolic Pressure
Authors: Pan Roubai , Xu Yan , Zong Xiao , Yang Qian , Tudi Xierenayi , Xi Rui , Fan Qin , Tao Rong
Published: November 2023

Background: Limited research has been conducted to investigate the impact of secondary mitral regurgitation (MR) in heart failure (HF) patients with different levels of estimated pulmonary artery systolic pressure (ePASP). Methods: A total of 468 patients suffering from HF and secondary MR were enrolled and categorized into non-severe and severe MR groups based on the degree of MR. The primary endpoint of the study was a composite of cardiovascular death and a first-heart-failure hospitalization. The secondary endpoints were the primary outcomes, individually. The outcomes of the two groups were compared. Patients were further classified based on whether their ePASP was ≥50 mmHg or <50 mmHg. Subsequently, the outcomes of the non-severe and severe MR groups were compared within each ePASP category. Results: In a median (SD) follow-up of 694 (410) days, severe MR was associated with higher risk for primary endpoints in patients with heart failure, especially in those with ePASP ≥50 mmHg. In patients with ePASP <50 mmHg, the prognostic value of severe MR was diminished. Conclusions: Assessment of the severity of MR can identify heart failure patients who are at greater risks for poor clinical outcomes. Additionally, the prognostic value of secondary MR was more pronounced in patients with elevated ePASP.
The law of the critical illness and its far-reaching implications
Authors: Ola Paul
Published: November 2023

The exact mechanistic process to be therapeutically modified towards solving the problem constituted by high mortality in very critically ill patients remains unexplored. Therefore, we avoided concepts of the phenomena in transparent animals to which the study of immunity resorted in the absence of the method by which the complexity of humans and those vertebrates that are the concern of our colleagues in veterinary healthcare may be surmounted towards a posteriori conception of the actual clinical phenomena. With the method that permitted Albert Einstein to unravel complex phenomena which were demonstrated by the Mercury problem to be beyond the reach of those senses that enabled astronomical observation, data collection and Sir Isaac Newton’s detailed data analysis of such data, we deduced the critical illness law that connects concepts of the actual phenomena to be observed in patients who are exempted from death by immunity mechanisms while others succumb. We found that individuals appear to be healthy without recovering from prior critical illnesses when these are rendered unapparent by mechanisms that permit the promotion of physical activity through adaptations that necessitate myoglobin expression towards rendering vertebrates apparently healthy. In the light of this result, we found the path on which research is to furnish the understanding of recovery towards the requisite therapies to be that on which we are to verifiably explain why fatiguing symptoms may worsen persistent illnesses towards underperformance and eventually disability following the failure of the myoglobin-dependent mechanisms of apparent health. In the light of the fact that such fatiguing symptoms that worsen with time may be followed by sudden death in patients on arrival at the hospital even without the symptoms that are expected in the absence of a posteriori concepts of the “spectral etiology theory of pathogenesis” which accommodates no more than the repeatedly proven version of the germ theory, that certain microscopic entities do exert pathological effects which may be conceived as diseases, we arrived the following conclusions. 1. The quantification of the processes by which the effects of such myoglobin-dependent mechanisms are restored is crucial to the discovery of treatments that permit effective management in non-recovering patients that even apparently healthy individuals are 2. The quantification of the processes behind the disappearance of such effects is necessary for early identification of those who, even while asymptomatic, already have severity so intensely precipitated by silently harbored microscopic entities that they may die even before arrival or even without benefiting from such treatments despite arrival if hospitalization is prompted by the severity of expected symptoms instead of the rapidity of such processes.
Interventionist Field Studies in Educational Technology Research
Authors: Pammer-Schindler Viktoria , Dennerlein Sebastian Maximilian , Maitz Katharina , Fessl Angela
Published: November 2023

Interventionist field studies place educational technology into a real-world environment (intervention) and investigate it there. However, field studies are often criticised for the lack of control that researchers have in such studies. With this paper we aim to provide a reference for interventionist field studies that lays out their nature based on socio-technical systems theory, describes their role in design-oriented research, and discusses how different types of research questions can be answered with an interventionist field study. We argue that interventionist field studies are uniquely well suited to answer research questions about 1) how an intervention works in the target environment of use, and 2) what changes over time; and are well suited to 3) develop design implications for future design iterations. We argue to be cautious in using interventionist field studies to answer comparative research question, especially if the intervention’s novelty is high. Finally, we give two recommendations for educational technology research: Recommendation 1) is to systematically develop, share and discuss design implications. Recommendation 2) is to develop rigour in non-comparative field studies by investigating multiple aspects of an intervention, which implies the use of complementary data sources and multiple analysis methods.
Preprint Non-Residential Fatherhood and Parenting Self-Efficacy
Authors: Osinga Mariëlle , Hartman Catharina , Kretschmer Tina
Published: November 2023

Growing up without biological father present in the home has been linked to child and adolescent wellbeing and development, but may have an impact that reaches beyond adolescence. Parenting and parent-child relationship quality one has experienced as child or adolescent are predictors of variation in one’s own parenting and similar processes might be detectable for experiences of non-residential fatherhood. However, our understanding of potential longer-term correlates of non-residential fatherhood that also affect the next generation would benefit from multiple-generation data, which are scarce. Moreover, potential mediators and moderators should be tested to further elucidate any association. To this end, we examined the link between non-residential fatherhood in adolescence and parenting self-efficacy approximately 15 years later, using a Bayesian approach that caters for small samples. In addition, we explored the potential role of the relationship between parents within this association. We used prospective, multiple-generation cohort data from the longitudinal TRAILS sample and its next generation spin-off, and included 137 parents (81% female, M age = 29.8) and their first-born children of ~30 months old (56% female). We found no support for an association between non-residential fatherhood at age 16 and later own parenting self-efficacy in emotional availability. Neither was there support for mediation or moderation of such an association by later negative interactions between parents in the data at hand, although we detected a positive link between non-residential fatherhood and negative parental interactions. Yet, it is important to re-evaluate conclusions using Bayesian updating once more data have been collected to further increase the confidence in the findings of this study.
Practical causal knowledge for sustainability: Implications of co-production for a philosophical understanding of causality in sustainability science
Authors: Caniglia Guido , Schlüter Maja
Published: November 2023

Participatory and collaborative processes of co-production in sustainability science combineknowledge generation and action, take place within the situations addressed by policies orinterventions, and stimulate mutual learning through inter- and transdisciplinary methodologies.In this Chapter, we introduce the notion of practical causal knowledge for sustainability. Usingexamples from participatory modelling, we highlight that the knowledge generated through coproductionin sustainability science can be both causal and practical. It is causal as it allows forunderstanding the complex dynamics underpinning sustainability problems and potentialsolutions in ways that are sensitive to the context, comprehensive, and inclusive. It is practical bothbecause it emerges from and because it is oriented towards the practical activities performed bydiverse scientific and non-scientific actors in specific situations to understand and addresscomplex sustainability problems. We argue that an appropriate philosophical account of practicalcausal knowledge for sustainability requires major shifts from existing philosophical accounts of‘causal knowledge for use and action’, that are tailored to fields that are not participatory andcollaborative. We conclude by arguing that practical causal knowledge for sustainability does notaim to predict and control dynamics of change, but to help navigate and find practical orientationwithin irreducibly complex situations.
Reflections, Processes, Collaborations: ISST Course on Women and Work Making it Count - A Process Document, First Iteration
Authors: Kaur Gurpreet , Kaur Ashmeet , Banerjee Monika
Published: November 2023

Sometime in the middle of 2019, a small team of researchers at ISST started to work along with an external consultant (Dipta Bhog) towards developing a curriculum on women and work that could engage withISST’s research work and attempt to contribute to the overall discourse on gender and labour. This was athought that was brewing within ISST for quite some time now and with ISST’s 40th year closer to the date, this felt an apt time to begin a process like this. Dipta Bhog, who has had an expertise in designing, curating and transacting curriculums, was brought on board only for this purpose. However, it was primarily the team at ISST that came together in doing all the leg work, bringing people together, building a team that could motivate each other in participating in such a learning and transformative process.
Understanding Pastoral Women's Work: An Exploratory Study
Authors: Kaur Gurpreet , Prateek  , Pawar Saee , Kumari Pawana
Published: November 2023

India, has a varied range of ecosystems and consists of several diverse pastoral communities, who have a close relationship with the ecosystems occupy and derive majority of their income from livestock keeping. Some studies in sociology and anthropology argue that in the Indian context ‘village’ has always been the focal point of Anthropological and development studies. Due to their constant migration and dispersed existence, pastoral communities could not gain the attention of researchers and policy makers. Pastoralists have also been largely excluded from the trajectory of development because of their non-sedantarized ways of living, as their movement is seen as an aberration from conventional development processes of the state. State-sponsored development has mostly failed to attend to the lived realities of pastoralists, further reducing their access to pastures by introducing movement restricting policies, which has only increased pressures of sedentarization. Furthermore, a pastoral woman is in a continuous engagement with forests, ecosystems, animals and land. Complex nature of their work has led to a failure to find their presence in literature and policies. The kind of labour they perform, their interaction with animals and ecology, and being in constant movement opens up ways to understand the role of women in the pastoral economy. It also allows possibilities to complicate the discourse on women and work from the perspective of non-sedentarized populations. Understanding Pastoral Women's work: an exploratory study is an attempt in this direction, to visibilize pastoral women’s work and to broaden the understanding of women’s work through engaging with lives of pastoral woman. Moreover, the attempt has also been to understand the role of ecological interactions of pastoral women (and pastoral community at large) in shaping the understanding of work as well as care. This has largely been the impetus to interact with the pastoral community and to bring forth, the understanding of relatedness which pastoral women have with various ecosystems and the work which they do.
Resilience Challenge Salience in Bioeconomy Policies: A Global Analysis
Authors: Schulz Nicolai , Proestou Maria , Feindt Peter
Published: November 2023

The sustainability of social-ecological systems has become a major concern in environmental policy. To address the sustainability challenges of the fossil-based economy, more than 50 countries around the world have promulgated policies to promote the transformation towards a bio-based economy. The success of this transformation, in turn, depends on the resilience of the bio-based production systems on which the bioeconomy rests. However, the continued delivery of the desired functions of these systems is challenged by environmental, social, economic, and political short- and long-term stresses. Despite the importance of such resilience challenges for a sustainable bioeconomy transformation, the extent to which they are addressed in bioeconomy policies remains unclear and under-researched. To fill this gap, we investigate the salience of resilience challenges in bioeconomy policies using the Resilience Policy Design (RPD) framework. Specifically, we conduct a systematic content analysis of bioeconomy policy documents in 50 countries to identify and discuss the specific challenges and instruments directly aimed at addressing these challenges. Overall, our analysis contributes to a better understanding of the role and origins of resilience concerns in global bioeconomy policymaking.
Eliciting the plurality of causal reasoning in social-ecological systems research
Authors: Hertz Tilman , Banitz Thomas , Peña Rodrigo Martinez , Radosavljevic Sonja , Lindkvist Emilie , Johansson Lars-Göran , Ylikoski Petri , Schlüter Maja
Published: November 2023

Understanding causation in social-ecological systems (SES) is indispensable forpromoting change toward sustainable outcomes. However, studying causal relations in SES ischallenging because they are often complex and intertwined, and because different disciplines areinvolved in their analysis. While there is agreement in the field that no single research approach(RA) can comprehensively explain change in SES (or the absence of it), there is a lack of abilityto deal with this diversity. Underlying this diversity and the challenge to deal with it are differentcausal reasonings that are rarely explicit. Awareness of hidden assumptions is crucial forunderstanding how causal reasoning of a RA gets constituted, and to promote the integration,translation, or juxtaposition of different approaches. We identify the following elements asparticularly relevant for understanding causal reasoning: Methods, frameworks and theories,accounts of causation, analytical focus and causal notions. We begin with the idea that one of theseelements typically figures as an entry point to a RA. This entry point is distinctive and particularlyimportant because it generates a path dependence which orients causal reasoning. In a subsequentstep, when an approach is applied, causal reasoning concretizes as a result of a particularconstellation of the remaining elements. We come to these insights by studying the application offour different RA to the same social-ecological case (the collapse of the Baltic cod in the 1980s).On the basis of our findings we developed a guide for the analysis of causal reasoning by raisingawareness of the assumptions, key elements and the relation between these key elements for agiven RA. This guide can also facilitate the combination of RA for different purposes, such asgetting a more comprehensive and interdisciplinary understanding of causation, discoveringunknowns, generating learning, articulating theories, or simply supporting reflexivity.
Bilateral sinus augmentation using Hydrodynamics for Functional and Esthetic maxillary rehabilitation
Authors: Praveen J. Arockia Antony , Parthassarathy Harinath , Lakshmi  , Sreepathy CS Raaja , Geetha
Published: November 2023

Edentulism is a prevalent oral health issue that negatively impacts the quality of life of the patient on a social and psychological level. For the treatment of edentulism, implant-supported prosthesis replacement is the most successful and supported treatment plan. Placement of an implant in the maxillary arch exposes a clinician to various complications like the quality of bone, pneumatization of the maxillary sinus, atrophic ridge, etc. This issue can be addressed with bone augmentation techniques using various bone graft materials which can improve the quality of bone and can also protect the sinus membrane. Current concepts in implant dentistry rely on techniques that are minimally invasive. Elevation of the sinus membrane can be performed by a minimally invasive procedure with the help of DASK kits. This case report discusses the full mouth maxillary rehabilitation with immediate implant placement after extraction of hopeless teeth in the anterior region followed by bone augmentation, indirect sinus lift and delayed implant placement in the maxillary molar region using a hydraulic sinus lift DASK kit. The patient has been reviewed periodically and the maxillary arch was later restored using a malo-bridge.
Correlation between Knowledge and Attitude with The Practice of Using PPE among Professional Dental Students at Jember University Dental Hospital, Indonesia: A Cross-Sectional Study
Authors: Muthmainnah Lailatul , Hadnyanawati Hestieyonini , Yani Ristya Widi Endah
Published: November 2023

Background: Hundreds of millions of nosocomial infection cases are estimated yearly worldwide. Nosocomial infections significantly lead to death and financial losses in the healthcare system. There is a need for infection mitigation, one of them is using Personal Protective Equipment (PPE). The importance of using PPE is still not supported by its compliance. Aim and Objective: This study aims to determine the relationship between knowledge and attitude toward PPE use among professional dental students at RSGM Universitas Jember. Materials and Method: The research method uses quantitative observational analytics cross-sectionally with questionnaires given through google forms and checklists filled out by researchers during observation. Variable involvement consists of knowledge, attitude, and practice in using PPE. It took 132 professional dental students as the respondents whose selection was done by stratified random sampling. Data analysis was performed univariate and bivariate using Microsoft Excel and the chi-square test on SPSS. Results: 81.8% of respondents had a good level of knowledge of PPE use, 81.1% of respondents had a positive attitude towards using PPE, and there were 22% of respondents who were not compliant using PPE. Respondents who did not comply with PPE came from dental treatment-producing aerosols. There was a relationship between knowledge and PPE use (p-value 0.002), but no relationship was found between attitude and PPE use (p-value 0.792). Conclusion: There was a relationship between knowledge and PPE use but no relationship between attitude and PPE use.