bluuebunny/crossref_metadata_2025 huggingface dataset:
Impact of extracellular-to-intracellular fluid volume ratio on albuminuria in patients with type 2 diabetes: A cross-sectional and retrospective cohort study
Authors: Nakajima Hanako , Hashimoto Yoshitaka , Kaji Ayumi , Sakai Ryosuke , Takahashi Fuyuko , Yoshimura Yuta , Bamba Ryo , Okamura Takuro , Kitagawa Noriyuki , Majima Saori , Senmaru Takufumi , Okada Hiroshi , Nakanishi Naoko , Ushigome Emi , Asano Mai , Hamaguchi Masahide , Yamazaki Masahiro , Fukui Michiaki
Published: February 2020

Background Body fluid volume imbalance is common in patients with kidney failure and is associated with all-cause mortality. We hypothesized that fluid volume imbalance occurs in diabetic patients without kidney failure and is associated with change in albuminuria. This study aimed to investigate the association between fluid volume imbalance and albuminuria in patients with type 2 diabetic mellitus without kidney failure. Methods We included 432 and 368 participants in the cross-sectional and retrospective studies. Body fluid imbalance was determined by measuring the extracellular water (ECW) to intracellular water (ICW) ratio (ECW/ICW) using bioelectrical impedance analysis. Change in urinary albumin to creatinine ratio (ACR) was defined as the ratio of urinary ACR at follow-up to that at baseline. ECW/ICW ratio was compared to level of albuminuria. Results In this cross-sectional study, ECW/ICW ratio increased with level of albuminuria (0.634 ± 0.002 in normo-, 0.645 ± 0.003 in micro- and 0.656 ± 0.004 in macroalbuminuria, all p <0.001 by Tukey's HSD test). In addition, there was an association between ECW/ICW ratio and logarithms urinary ACR after adjusting for covariates (β = 0.217, p <0.001). Moreover, ECW/ICW ratio was associated with change in the urinary ACR after adjusting for covariates (β = 0.171, p = 0.005) in this retrospective study. Conclusions ECW/ICW ratio is independently associated with level of albuminuria in patients with type 2 diabetes mellitus without kidney failure. This reinforces the importance of monitoring fluid balance in patients with type 2 diabetes mellitus.
Development and Evaluation of Quality of Life Instruments for Chronic Diseases–Chronic Pulmonary Heart Disease (QLICD-CPHD) (V2.0)
Authors: Pan Haiyan , Yang Zheng , Wan Chonghua , Ruan Jinghao , Wu Bin , Li Na , Wang Xingjie , Zhao Zhihuan
Published: February 2020

Objective: To develop a quality of life (QOL) instrument specific to chronic pulmonary heart disease (CPHD) and to evaluate its reliability, validity, and responsiveness. Methods: Under the Quality of Life Instruments for Chronic Diseases (QLICD) system, the QLICD-CPHD (V2.0) was developed and used to measure the QOL of 184 patients with CPHD. Data were analyzed by statistical description, linear correlation analysis, exploratory factor analysis, and paired t-test. Results: The QLICD-CPHD (V2.0) consisted of 44 items, including 28 in the general module and 16 in the specific module. The Cronbach’s α coefficients of four domains in the general module and the specific module were greater than 0.7, and the split-half reliability coefficients were between 0.6 and 0.8, indicating that the instrument has good reliability. The instrument showed good validity as the correlation coefficients among items of the same domain were significantly higher than those among items of different domains. Correlation coefficients r between the corresponding domains of SF-36 and QLICD-CPHD were between 0.26 and 0.60, which suggests that QLICD-CPHD has moderate criterion validity. Paired t-tests of scores of patients before and after treatment showed significant differences in the overall score, scores of general module domains except social role, and scores of the specific module. Standardized response means were greater than 0.2, suggesting that the instrument had moderate responsiveness and was sensitive to changes in the patients’ QOL. Conclusion: The QLICD-CPHD (V2.0) has good reliability, validity, and responsiveness. The instrument can be used to evaluate the QOL of CPHD patients.
The genetic role of Glutathione S-Transferase Mu 3 (GSTM3) intron 6 polymorphism in the susceptibility to cancer
Authors: Wang Yanyan , Feng Han , Yu Junlin , Du Yabing , Jin Shuiling , Ma Wang , Cui Kang
Published: February 2020

Background We retrieved different reports containing different genetic effects of A/B polymorphism within the Glutathione S-Transferase Mu 3 (GSTM3) intron 6 on the susceptibility to cancer in the overall population. Methods Herein, we first conducted a meta-analysis to comprehensively assess such a genetic relationship after collecting the available published evidence. STATA 12.0 software was used for the statistical analysis. Results By retrieving and screening database literature, a total of fifty-three eligible articles were finally selected. Even though no significant difference between overall cancer cases and negative controls was detected under the allelic, homozygotic, heterozygotic, dominant and recessive genetic model, we observed a reduced risk of head and neck cancer in cases, compared with controls, under the homozygotic model (BB vs. AA, P =0.047, OR=0.75) and recessive model (BB vs. AA+AB, P =0.045, OR=0.76), but not other models. Furthermore, a decreased risk of head and neck SCC cancer was detected under all the genetic models (allelic B vs. A, P =0.007, OR=0.78; BB vs. AA, P =0.006, OR=0.54; AB vs. AA, P =0.045, OR=0.82; AB+BB vs. AA, P =0.002, OR=0.77; BB vs. AA+AB, P =0.021, OR=0.63; carrier B vs. A, P =0.032, OR=0.83). Conclusion Our findings suggested that the GSTM3 intron 6 A/B polymorphism may confer the protective susceptibility to the squamous cell carcinoma of head and neck.
Shenmai injection alleviates acute lung injury in a severe acute pancreatitis rat model via heme oxygenase-1 upregulation
Authors: Zhang Fei-hu , Hao Hao , Liu Yang , Fan Kai-liang , Dai Wen , Liu Wei-hong , Kong Li
Published: February 2020

Objective To determine the effect of Shenmai injection (SMI) on acute lung injury (ALI) induced by severe acute pancreatitis (SAP) in rats. Methods 40 male SD (Sprague-Dawley) rats were grouped into 4 categories: SAP group, sham surgery (SS) group, SAP + SMI group, SAP + SMI + Zinc protoporphyrin (ZnPP) group. 30 minutes after induction of SAP, the SAP group rats were intravenously injected with 1.6 ml/kg saline, the SAP + SMI group rats were intravenously injected with 1.6 ml/kg SMI, while the SAP + SMI + ZnPP group rats were intravenously injected with 1.6 ml/kg SMI and 30 mg/kg ZnPP via intraperitoneal injection. 24 hours after SAP induction, the rats were sacrificed. Histological evaluation of the lung tissues, protein concentration in BALF and lung wet-to-dry (W/D) weight ratio were determined and analyzed. Blood and tissue samples were also collected to determine the levels of protein expression and mRNA of the tumor necrosis factor (TNF) -α, HO-1 and interleukin (IL) -10. Results Compared to the SAP group, SAP-induced ALI was significantly attenuated by SMI treatment and had a lower score of lung damage severity ( p <0.05). SMI significantly attenuated the SAP-induced rise in BALF and W/D ratio protein concentrations ( p <0.05). The SMI treatment resulted in a statistically significant increase of HO-1, IL-10 levels and a significant reduction of TNF-α level in both serum and tissue samples ( p <0.05). However, inhibition of HO-1 expression by ZnPP led to significant inhibition of all the changes. Conclusions SMI can alleviate SAP-induced ALI through HO-1 upregulation.
Evaluation and application of the quartz-inclusions-in-epidote mineral barometer
Authors: Cisneros Miguel , Ashley Kyle T. , Bodnar Robert J.
Published: February 2020

We have examined the suitability of a quartz-inclusions-in-epidote (qtz-in-ep) mineral barometer to better constrain P-T histories of epidote-bearing lithologies. Theoretical calculations applying an isotropic elastic model suggest that the qtz-in-ep barometer exhibits minimal temperature dependence, and thus, offers the potential to constrain growth conditions of epidote in various geologic environments, including skarn deposits, epidote-bearing granitoids, and metamorphic rocks.

To test if the applied equations of state and isotropic elastic model reasonably simulate the elastic evolution of two anisotropic minerals, we measured Raman shifts of the 464 cm–1 band of quartz inclusions relative to that of an unencapsulated quartz standard. We calculated a quartz inclusion pressure (Pincl464) at various temperatures and compared these values with temperature-dependent Pincl predicted by elastic modeling (Pinclmod) at elevated temperatures. Three epidote-bearing samples with reasonably well-constrained P-T histories were also examined: (1) sample HF14C from the Upper Schieferhuelle in the Western Tauern Window, Italy (Pincl464=0.01 GPa); (2) sample LdC-31C from Lago di Cignana, Italy (Pincl464≈0.16 GPa); and (3) sample FT1E from the Frosnitz Tal in the Western Tauern region, Austria (Pincl464=0.57 GPa).

Entrapment pressures (Pent464) calculated from Pincl464 determined at various temperatures show nominal differences from Pent calculated from Pinclmod, suggesting that for qtz-in-ep pairs, the calculated Pent does not significantly vary with the temperature of measurement. Furthermore, our calculated Pent464 for a sample from the Upper Schieferhuelle is in agreement with petrographic context and previously established P conditions, and the Pent464 determined for the Frosnitz Tal sample closely approximate previously reported pressures. The Lago di Cignana sample is derived from an epidote vein that is encased in a high-P foliation, and the calculated Pent464 is consistent with early, low-P epidote vein formation that pre-dates high-P metamorphism, or alternatively, late vein formation during exhumation, and confirms that the epidote did not form at or near peak conditions (~2.0 GPa). The results of this study indicate that the qtz-in-ep barometer potentially provides another tool that geoscientists can employ to better constrain P-T conditions in some epidote-bearing environments, where conventional thermobarometric techniques cannot be applied.
Particle representation for $NN{\bar K}$ system
Authors: Vlahovic Branislav , Filikhin Igor , Kezarashvili Roman Ya.
Published: February 2020

In the framework of the Faddeev equations in configuration space we
perform an analysis of quasi-bound state of the
NN{\bar K}NNK‾
system within a particle model. In our approach, the system
NN{\bar K}(s_{NN}=0)NNK‾(sNN=0)
(NN{\bar K}(s_{NN}=1))NNK‾(sNN=1))
is described as a superposition of ppK^{-}ppK−
and pn{\bar K}^0pnK‾0
(nn{\bar K}^{0}nnK‾0
and pn{ K}^-pnK−)
states, which is possible due to a particle transition. The relation of
the particle model to the theory of a two-state quantum system is
addressed and discussed taking into account the possibilities of deep
and shallow NN{\bar K}(s_{NN}=0)NNK‾(sNN=0)
quasi-bound states.
Stimulating and limiting factors for the growth of investment potential of Ukrainian insurance companies
Authors: Cherkasova Svitlana , Kalaitan Tetyana , Rushchyshyn Nadiia , Yaremko Igor , Yaroshevych Nataliia
Published: February 2020

The fact that the accumulated investment potential (IP) of insurance companies (IC) does not have a significant impact on the processes of economic growth in Ukrainian practice actualizes the task of researching the practice of investing in the activities of domestic insurers. The purpose of the study is to find out, classify and highlight the main factors that influence the formation of the Ukrainian IC’ IP and give recommendations for overcoming a number of related difficulties. According to the results of investigation of the Ukrainian insurance industry development trends in 2011–2018, it was concluded that rates of their IP accumulation are insufficient. There is a decrease in the aggregate value of insurers’ investment assets and a reduction in the composition of investment attractive financial instruments. Low efficiency and simplification of investment strategies of IC are noted. The factors that exert a stimulating and inhibitory influence on the investment processes in the Ukrainian insurance market were identified. Ways and tools were proposed to strengthen the effect of incentive factors and eliminate or minimize the effect of the considered restrictive factors that can be used in the practice of state regulation of the insurance industry of the country. Considering the examined factors should allow the state regulators making more effective decisions to improve the investment activity of insurers and enhance its importance in the development of the national economy.
Delft Dashboard: a quick set-up tool for hydrodynamic models
Authors: van Ormondt Maarten , Nederhoff Kees , van Dongeren Ap
Published: February 2020

The open-source program Delft Dashboard (DDB) is a graphical user interface designed to quickly create, edit input parameters and visualize model inputs for a number of hydrodynamic models, using private or publicly available local and global datasets. It includes a number of toolboxes that facilitate the generation of spatially varying inputs. These include new model schematizations (grids, bathymetry, boundary conditions, etc.), cyclonic wind fields and initial tsunami waves. The use of DDB can have significant benefits. It can save modellers considerable time and effort. Furthermore, the automated nature of both data collection and pre-processing within the program reduces the likelihood of errors that could occur when setting up models manually. Three case studies are presented: simulation of tides in the North Sea, storm surge and wave modelling under tropical cyclone conditions and the simulation of a tsunami. The test cases show that models created with DDB can be set up efficiently while maintaining a predictive skill that is only slightly lower than that of extensively calibrated models.
Effects of fertigation on corrosion in galvanized steel used in center pivot systems
Authors: Rodrigues Karina V. , Lima Luiz A. , Thebaldi Michael S.
Published: February 2020

One of the main causes of agricultural equipment deterioration is corrosion. In center pivot irrigation systems, deterioration mainly occurs in galvanized steel pipelines. Fertigation can increase corrosion because fertilizers become corrosive when exposed to water or moisture; this corrosion reduces the service lifetime of the equipment. In this study, fertigation-induced corrosion was evaluated in specimens of galvanized steel (similar to that used in center pivot systems), simulating 10 years of operation comprising 5 fertigations per year with a duration of 7 hours each. Immersion tests were performed in solutions containing 0, 5 and 10 g/L fertilizer concentrations to obtain the mass loss per unit area of the metallic material, which increased in response to increases in both the exposure time in the corrosive environment and the fertilizer concentration. The results showed that fertigation increases corrosion in galvanized steel and the higher fertilizer concentration leads to a higher corrosion, since, for the same exposure time, the mass loss for the 10 g/L solution was 43% greater than the 5 g/L.
Editorial
Authors: Araújo Marta Maria de
Published: February 2020

Editorial
Konsep pemikiran Mohammed Arkoun dalam aina huwa alfikr al-islāmiy al-mu’āshir
Authors: Rasyid Ruslan , Djafar Hilman
Published: February 2020

Mohammed Arkoun's thought in his monumental work, "aina huwa al-fikr al-islāmiy"was inspired by two famous Muslim intellectuals, Imam Ghazali and Ibn Rusyd. Arkoun'swork is an idea that spurs the spirit of contemporary Muslims to think ahead by using all thepotential they have so that it can make Islam a religion that can adapt to the development ofthe times or in a religious language called shālihun likulli makānin wa shālihun likulli zamānin.In addition, the concept of thought in the work is aimed primarily at opening up broaderhorizons of Arabic Islamic thought and can be used as a method of understandingcontemporary social science based on Islamic views. One effort undertaken by MohammedArkoun is to consolidate modern historical methodology with classical Islamic thought,because for Arkoun that is the only way to achieve a scientific understanding of the historicalthe reality of Islamic society. The perceived impact is the disappearance of all disputes, bothracial and religious. Some of the directions of his thinking are as follows: 1) Arkoun's way ofperceiving himself; 2) Agendas that must be implemented include building an appliedIslamology / islāmiỹāt tathbȉqhiỹah by trying to apply scientific methodology to the Koran;3) The Western way (alGharb) knows Islam; 4) Return to the starting point; 5) Secularismand Islam; 6) Islam, Science, and Philosophy; 7) Islam and Human Rights; 8) Sufism;9) European nationalism; 10) Think openly.
Inovasi pembelajaran berbasis teori kecerdasan majemuk untuk pengembangan peran sekolah di era 4.0
Authors: Priyambodo Panggih
Published: February 2020

Industrial Revolution Era 4.0 has brought disruption phenomena in various fields of life. The characteristics of the younger generation also experienced a shift, especially those that occurred in the millennial generation (gen Y) and generation Z. This condition encouraged schools as formal educational institutions to organize learning processes that can answer global challenges. Innovations in the learning process must be done continuously, one of them through the development of multiple intelligences and the involvement of learning technology elements. The development of multiple intelligences in the learning process requires the creativity of the teacher in selecting and determining the right models and learning strategies. The assessment instrument is not only directed at measuring cognitive aspects but also covers all aspects of competency as required by students. Learning patterns based on the development of multiple intelligences will be more effective if done by raising issues and real problems. Through an inquiry project, students will be actively involved in various forms of learning activities to make it an opportunity to bring up multiple types of abilities. The learning process, based on the development of multiple intelligences, is expected to be able to develop student competencies as a whole. The final result is the formation of adaptive individuals who are able to compete in the industrial revolution 4.0 era without having to leave their local culture.Era Revolusi Industri 4.0 telah membawa dampak fenomena disrupsi di berbagai bidang kehidupan. Karakteristik generasi muda juga mengalami pergeseran, terutama yang terjadi pada generasi milenial (gen Y) dan generasi Z. Kondisi ini mendorong sekolah sebagai lembaga pendidikan formal untuk menyelenggarakan proses pembelajaran yang mampu menjawab tantangan global. Inovasi dalam proses pembelajaran harus terus dilakukan salah satunya melalui pengembangan kecerdasan majemuk (multiple intelligences) serta pelibatan unsur teknologi pembelajaran. Pengembangan kecerdasan majemuk di dalam proses pembelajaran membutuhkan kreativitas dari para guru dalam memilih dan menetapkan model maupun strategi pembelajaran yang tepat. Instrumen penilaian juga tidak hanya diarahkan pada pengukuran aspek kognitif saja melainkan mencakup keseluruhan aspek kompetensi sebagaimana yang dibutuhkan peserta didik. Pola pembelajaran berbasis pengembangan kecerdasan majemuk akan lebih efektif jika dilakukan dengan mengangkat isyu-isyu maupun permasalahan nyata. Melalui proyek penyelidikan, peserta didik akan terlibat aktif di berbagai bentuk kegiatan belajar sehingga menjadikannya berkesempatan untuk memunculkan berbagai bentuk kemampuan. Proses pembelajaran berbasis pengembangan kecerdasan majemuk diharapkan mampu menumbuhkembangkan kompetensi peserta didik secara menyeluruh. Hasil akhirnya adalah terbentuknya individu-individu adaptif yang mampu bersaing di era revolusi industri 4.0 tanpa harus meninggalkan kultur lokalnya.
Indigenousasi Sebagai Jembatan Pendidikan Karakter dalam PAUD Melalui Learning By Culture
Authors: Rolina Nelva
Published: February 2020

Bangsa Indonesia sedang mengalami keterpurukan dekade ini, karena minim sekali insan-insan cendikia yang berkarakter. Pendidikan karakter menjadi sangat penting dan menjadi sorotan, sehingga pemerintah mencanangkan pendidikan karakter sebagai simbol dunia pendidikan saat ini. Namun, penanaman karakter yang kuat tidaklah semudah membalik telapak tangan. Seharusnyalah dilakukan sejak usia kanak-kanak. Masa kanak-kanak yang lazim disebut masa keemasan (golden age) sangat rentan terhadap stimulasi, baik itu stimulasi yang benar maupun yang salah. Seperti teori tabularasa, anak diibaratkan kertas putih yang mudah untuk diberi tulisan apapun, atau laksana botol kosong yang bisa diisi air apapun. Hal ini karena dalam otak anak terdapat ribuan neuron yang sedang terkoneksi satu sama lain. Untuk menanamkan karakter sejak masa kanak-kanak, perlu intervensi mendalam pada pendidikan anak usia dini (PAUD) melalui indigenousasi ke-Indonesia-an sebagai jembatannya, yaitu pembelajaran yang kembali pada tradisi dan budaya (learning by culture).   Kata kunci: Indigenousasi, Karakter, PAUD
Memenuhi Hak Anak Berkebutuhan Khusus Anak Usia Dini Melalui Pendidikan Inklusif
Authors: Rahayu Sri Muji
Published: February 2020

Hak anak adalah bagian dari hak asasi manusia yang wajib dijamin, dilindungi, dan dipenuhi oleh orang tua, keluarga, masyarakat, pemerintah, dan negara. Hak anak yang wajib dipenuhi diantaranya adalah hak untuk memperoleh pendidikan dan pengajaran. Anak berkebutuhan khusus usia dini juga berhak mendapatkan layanan pendidikan. Anak berkebutuhan khusus usia dini yang ada di masyarakat belum semuanya mendapatkan layanan di pendidikan anak usia dini. Hal ini disebabkan karena keberadaan pendidikan anak usia dini belum mampu memberikan pelayanan sesuai dengankebutuhannya. Untuk memberikan pelayanan anak berkebutuhan khusus usia dini, maka pendidikan anak usia dini yang telah ada seharusnya dapat menerima dan melayani anak berkebutuhan khusus. Pelayanan pendidikan anak usia dini yang memberikan pelayanan bersama-sama antaraanak yang tidak mengalami hambatan dan anak berkebutuhan khusus disebut pendidikan anak usia dini inklusif. Pendidikan inklusif adalah sistem pendidikan yang menyertakan semua anak secara bersama-sama dalam suatu iklim proses pembelajaran dengan penyelenggaraan pendidikan yang memberikan kesempatan kepada semua anak secara bersama-sama dalam suatu iklim proses pembelajaran dengan layanan pendidikan yang layak dan sesuai kebutuhan individu siswa tanpa membedakan anak dari latar belakang suku, ras, status sosial, kemampuan ekonomi, status politik, bahasa, geografis, jeniskelamin, agama/kepercayaan, dan perbedaan kondisi fisik atau mental. Kata kunci: hak anak, anak berkebutuhan khusus usia dini, pendidikan inklusif
PENANAMAN PENDIDIKAN KARAKTER CINTA LINGKUNGAN MELALUI JARI KREASI SAMPAH BOCAH CILIK DI KAWASAN PARANGTRITIS
Authors: Harlistyarintica Yora , Wahyuni Hana , - Widiyawanti , Yono Nur , Sari Indah Permata , Cholimah Nur
Published: February 2020

Pelatihan ini bertujuan untuk menanamkan karakter cinta lingkungan pada anak-anak usia 4- 12 tahun di kawasan wisata Parangtritis. Usia tersebut merupakan usia emas dalam tumbuh kembang anak yang memungkinkan adanya penanaman karakter cinta lingkungan. Metode yang digunakan dalam pelatihan ini berupa bermain, bercerita, menyanyi dan demonstrasi. Kegiatan yang dilakukan berupa eksplorasi sampah, outbond, pembuatan kerajinan (gelas plastik, tutup botol dan botol) dan lomba kreasi sampah. Sasaran kegiatan ini berjumlah 30 anak dari wilayah Parangtritis. Pendidik dalam kegiatan ini yaitu tim pelaksana program kreativitas mahasiswa Jari Kreasi Sampah Bocah Cilik. Hasil dari kegiatan ini anak mampu membuat kreasi sampah sebagai wujud rasa cinta terhadap lingkungan. Kreasi tersebut berupa boneka kelinci, boneka tutup botol, boneka laba-laba, dan lukis botol. Anak-anak terlihat antusias selama mengikuti kegiatan. Orang tua sangat mendukung kegiatan ini terlihat dari keterlibatannya dalam mendampingi anak. Kata kunci: karakter, cinta lingkungan, sampah, anak
Implementing Structured Clinical Templates at a Single Tertiary Hospital: Survey Study
Authors: Hwang Ji Eun , Seoung Byung Ook , Lee Sang-Oh , Shin Soo-Yong
Published: February 2020

Background

Electronic health record (EHR) systems have been widely adopted in hospitals. However, since current EHRs mainly focus on lowering the number of paper documents used, they have suffered from poor search function and reusability capabilities. To overcome these drawbacks, structured clinical templates have been proposed; however, they are not widely used owing to the inconvenience of data entry.

Objective

This study aims to verify the usability of structured templates by comparing data entry times.

Methods

A Korean tertiary hospital has implemented structured clinical templates with the modeling of clinical contents for the last 6 years. As a result, 1238 clinical content models (ie, body measurements, vital signs, and allergies) have been developed and 492 models for 13 clinical templates, including pathology reports, were applied to EHRs for clinical practice. Then, to verify the usability of the structured templates, data entry times from free-texts and four structured pathology report templates were compared using 4391 entries from structured data entry (SDE) log data and 4265 entries from free-text log data. In addition, a paper-based survey and a focus group interview were conducted with 23 participants from three different groups, including EHR developers, pathology transcriptionists, and clinical data extraction team members.

Results

Based on the analysis of time required for data entry, in most cases, beginner users of the structured clinical templates required at most 70.18% more time for data entry. However, as users became accustomed to the templates, they were able to enter data more quickly than via free-text entry: at least 1 minute and 23 seconds (16.8%) up to 5 minutes and 42 seconds (27.6%). Interestingly, well-designed thyroid cancer pathology reports required 14.54% less data entry time from the beginning of the SDE implementation. In the interviews and survey, we confirmed that most of the interviewees agreed on the need for structured templates. However, they were skeptical about structuring all the items included in the templates.

Conclusions

The increase in initial elapsed time led users to hold a negative opinion of SDE, despite its benefits. To overcome these obstacles, it is necessary to structure the clinical templates for optimum use. In addition, user experience in terms of ease of data entry must be considered as an essential aspect in the development of structured clinical templates.
Analysis of Benzodiazepine Prescription Practices in Elderly Appalachians with Dementia via the Appalachian Informatics Platform: Longitudinal Study (Preprint)
Authors: Bhardwaj Niharika , Cecchetti Alfred A , Murughiyan Usha , Neitch Shirley
Published: February 2020

BACKGROUND

Caring for the growing dementia population with complex health care needs in West Virginia has been challenging due to its large, sizably rural-dwelling geriatric population and limited resource availability.

OBJECTIVE

This paper aims to illustrate the application of an informatics platform to drive dementia research and quality care through a preliminary study of benzodiazepine (BZD) prescription patterns and its effects on health care use by geriatric patients.

METHODS

The Maier Institute Data Mart, which contains clinical and billing data on patients aged 65 years and older (N=98,970) seen within our clinics and hospital, was created. Relevant variables were analyzed to identify BZD prescription patterns and calculate related charges and emergency department (ED) use.

RESULTS

Nearly one-third (4346/13,910, 31.24%) of patients with dementia received at least one BZD prescription, 20% more than those without dementia. More women than men received at least one BZD prescription. On average, patients with dementia and at least one BZD prescription sustained higher charges and visited the ED more often than those without one.

CONCLUSIONS

The Appalachian Informatics Platform has the potential to enhance dementia care and research through a deeper understanding of dementia, data enrichment, risk identification, and care gap analysis.
β-Carotene patch application effects on gingival crevicular fluid volume after panoramic radiography exposure
Authors: Andini Anggun Dwi , Widyaningrum Rini , Shantiningsih Rurie Ratna
Published: February 2020

Panoramic radiography is a radiography technique which is commonly used in dentistry. X-ray radiation from panoramic radiography can cause biological damage, such as the increase of gingival crevicular fluid (GCF) volume. One of materials which was known having the ability to decrease the effect of panoramic radiography is β-carotene in mucoadhesive gingival patch form. The application of β-carotene mucoadhesive gingival patch reduce micronucleus increasing in previous study. The aim of this study is to determine the effect of β-carotene mucoadhesive gingival patch application on palatal gingiva of maxillary incisor teeth to the GCF volume of panoramic radiography exposed patients. This study involved 10 subjects (5 females and 5 males). The GCF sample was taken from the labial sulcus of 11, 12 teeth (treatment group) and 21, 22 teeth (control group) of each subject before and after panoramic radiography exposure. β-carotene mucoadhesive gingival patch was applicated on palatal gingiva before panoramic radiography examination. Sample was collected using an absorbent paper which is inserted to the labial gingival sulcus. The GCF on the absorbent papers were marked by adding ninhydrin 2%, then the GCF volume was measured using a sliding caliper. Paired t-test result shows a significant difference between GCF volume in each group before and after panoramic radiography exposure (p<0.05). Independent t-test shows no significant difference between the GCF volume difference in the control and treatment group (p>0.05). The result of this study shows that the application of β-carotene mucoadhesive gingival patch on palatal gingiva of maxillary incisor teeth shows insignificant effect in decreasing the increase of GCF volume in panoramic radiography exposed patients.
Nanotecnologías para la energía en México: revisión de publicaciones científicas, patentes y empresas
Authors: Arteaga Figueroa Edgar Ramón , Záyago Lau Edgar , Foladori Guillermo
Published: February 2020

Objetivo: establecer y revisar el estado actual de las nanotecnologías aplicadas al sector energético en México, desde la Investigación y Desarrollo (I+D) hasta las patentes y dispositivos en el mercado.Método: se realizó un análisis bibliométrico de publicaciones científicas, se recolectaron datos sobre los grupos de investigación en el tema, se conformó un catálogo de patentes y, finalmente, se hizo una descripción de las empresas mexicanas que producen instrumentos y dispositivos para generar, almacenar o volver eficiente el uso final de la energía.Resultados: entre 2000 y 2019 se han realizado 82 publicaciones y hay proyectos de investigación en más de 50 centros públicos; asimismo, hay empresas nacionales e internacionales que patentan y ofrecen productos nanohabilitados para la generación, almacenamiento y distribución de energía.Limitaciones: actualmente no se cuenta con una estrategia nacional sobre nanotecnologías en el país; la información fue recolectada y sistematizada de distintas fuentes, documentos e informes oficiales.Principales hallazgos: este es un primer ejercicio que permite visualizar una desarticulación entre lo que se investiga, patenta y produce en materia de nanotecnologías aplicadas al sector energético de México.
Antidiabetic activities of 96% ethanol extract of Abelmoschus esculentus on Balb-C mice strain
Authors: Aditama Agnis Pondineka Ria
Published: February 2020

Diabetes mellitus (DM) is a progressive metabolic disease that continues to increase every year. Treatment therapy using oral hypoglycemic drugs to treat DM has side effects, and alternative approaches must be taken. Abelmoschus esculentus has been known to be used as an alternative to DM because it has antioxidant activity due to its high flavonoid content. The purpose of this study was to determine the antidiabetic activity of 96% ethanol extract of Okra leaves against male mice of balb-c strain. Male mice were acclimatized for seven days and divided into five test groups and then fasted for 18 hours. Then the mice were induced with 150 mg / 20 g BW alloxan and measured on the 3rd day. Ethanol extract 96% okra leaves were then given in a dose of 5.6 mg / 20g BW; 11.2 mg / 20g BW; 22.4 mg / 20g BW, CMC Na 0.5% as negative control and glibenclamide 0.026 mg / 20g BBs as positive control for 14 days. The results of therapy with 96% ethanol extract of okra leaves can reduce blood glucose levels in mice so that the okra leaves contain flavonoid compounds that have antioxidant activity and can reduce blood glucose levels.
Bagaimana meningkatkan school well-being? Memahami peran school connectedness pada siswa SMA
Authors: Rahma Ulifa , Faizah Faizah , Dara Yuliezar Perwira , Wafiyyah Najwa
Published: February 2020

Abstrak. Penelitian ini dilakukan untuk melihat pengaruh school connectedness dengan school well-beng siswa Sekolah Menengah Atas. Penelitian ini merupakan penelitian kuantitatif yang terdiri dari siswa SMA sebanyak 134 orang berdasarkan perhitungan aplikasi G*Power versi 3.1.9.2. Pengambilan data dilakukan dengan cara membagikan 2 skala yaitu skala school connectedness dan skala school well being dengan menggunakan metode accidental sampling. Uji analisis data dalam penelitian ini menggunakan pearson product moment. Hasilnya ialah terdapat hubungan positif dengan (r=0.77, p= 0.00) yang berarti terdapat hubungan antara variabel school connectedness dengan school well being pada siswa Sekolah Menengah yang signifikan. Hasil penelitian ini memiliki nilai yang positif dimana terdapat hubungan positif antara variabel yaitu semakin tinggi tingkat school connectedness siswa terhadap sekolahnya maka semakin tinggi pula tingkat school well beingnya, dan sebaliknya. Dimensi school connectedness yang berpengaruh terhadap school wellbeing adalah being connected and liked by students, communication dan being liked by teachers. Namun untuk dimensi belonging tidak memiliki pengaruh terhadap school wellbeing pada siswa SMA. Dimensi school connectedness yang memiliki effect size terbesar adalah being liked by teachers kemudian communication dan yang terakhir adalah being connected and liked by students.Kata kunci: school connectedness, school well-being, Sekolah Menengah Abstract. This research was conducted to look at the relationship between school and school - both in high school students. This research is a quantitative study involving subjects consisting of 134 high school students based on the calculation of the application G * Power version 3.1.9.2. Data retrieval is done by connecting two scales, namely the scale of school connectivity and school scale using the accidental sampling method. Test data analysis in this study using Pearson product moment. What is the positive relationship with (r = 0.77, p = 0.00) which means that the relationship between the school and school variables in the Middle School students is significant. The results of this study have a positive value. Where there is a positive relationship between variables, the higher the level of student school connection to the school, the higher the school level will be, and vice versa. Dimensions school connectedness related to school wellbeing are related and liked by students, communication and liked by teachers. But belonging does not have an influence on school wellbeing in high school students. The dimension of school connectednes which has the greatest effect size is liked by the teachers then communication and the last is connected and liked by students.Keywords: school connectedness,school well-being, secondary school
Muhammadiyah dan Agenda Gerakan untuk Indonesia yang Beradab
Authors: Alfian M. Alfan
Published: February 2020

Paper ini adalah refleksi intelektual tentang Muhammadiyah dan kaitannya dengan agenda gerakan untuk Indonesia yang beradab. Tujuan utama dari pewacanaan masalah ini, sebagai upaya membangun gagasan alternatif untuk menjawab pelbagai fenomena krisis kemanusiaan yang telah menjangkiti bangsa ini. Tulisan yang terinspirasi dari buah permenungan artistik seorang cendekiawan, sastrawan dan tokoh bangsa terkemuka, HAMKA, membawa kepada suatu gagasan brilian yang menegaskan bahwa Muhammadiyah harus menjadi pelopor gerakan pemikiran inklusif. Dengan demikian, birokratisme yang kerap menjadi masalah bagi setiap institusi sosial keagamaan yang sudah mapan, tidak menjadi halangan untuk menebarkan nilai-nilai kebajikan universal tersebut.
In vitro production of porcine embryos with use of chemically semi-defined culture media system
Authors: Urbán Duarte David , Álvarez Gallardo Horacio , Pérez Reynozo Sandra , De la Torre Sánchez José Fernando
Published: February 2020

The objective of this study was to determine the effect of a semi-defined culture media system developed in our laboratory, named Pigs Media System (PMS) on the in vitro production of porcine embryos. In a first assay, the cummulus-oocytes complexes (COCs) were matured, fertilized and cultured for embryo development in PMS supplemented with bovine serum albumin (BSA), and in North Carolina State University-23 (NCSU-23) supplemented with fluid follicular, until blastocysts evaluation. In the assay 2, maturation and culture were performed in PMS using BSA or polyvinyl alcohol (PVA) in a 2 × 2 factorial arrangement (PMS-BSA/BSA, PMS-BSA/PVA, PMS-PVA/PVA, PMS-PVA/BSA). The PMS had a positive effect on the total cell number (58.04) and the decrease of the total lipids (49.4%) regarding the NCSU-23 medium (37.98 and 59.2% respectively; p<0.05). The percentage of monospermic fertilization was significantly lower (42.3%; p<0.05) when oocytes were matured with PMS-BSA than in PMS-PVA (52.6%). The supplementation of BSA in the PMS for embryo culture, increased the blastocyst development, the cell number of blastocysts and decreased the content of total lipids (36.8%, 46.9 and 49.6% respectively; p<0.05), in comparison with the supplementation of PVA in the PMS for embryo culture. These results suggest that the semi-defined culture media system developed by the National Genetic Resources Center (CNRG), have proved favorable effects on the total cell number and the decrease of total lipids of porcine blastocysts in vitro produced.
Captura à vida de alto executivo: Dispositivos em cenas cotidianas
Authors: Vogel Olbermann Junia , Iochins Grisci Carmem Ligia
Published: February 2020

O presente estudo buscou apresentar e discutir a vida de alto executivo na perspectiva dos dispositivos que a sustentam. Para tanto, empreendeu-se uma pesquisa exploratória qualitativa que contou com a participação de altos executivos de empresas de médio/grande porte localizadas no Brasil. Alcançados por meio da análise de conteúdo das entrevistas individuais realizadas com 26 participantes, os resultados dizem da vida vivida e da vida encenada de alto executivo. Condizentes com os ditames organizacionais, o dom, a bajulação e a glamourização dizem respeito, respectivamente, aos dispositivos de engajamento, sedução e captura de modo a sustentarem a vida de alto executivo.
Políticas Cognitivas: Ontologias da Autoconsciência
Authors: Baum Carlos , Maraschin Cleci
Published: February 2020

Neste texto a discussão é feita considerando as proposições a cerca de políticas cognitivas, compreendendo que a representação pode ser alcançada através de diferentes agenciamentos que distribuem de maneira diversa os atores envolvidos. Exploramos três políticas diferentes para compor, representar e reconhecer um processo cognitivo, a autoconsciência. 1) Uma política de mensuração, performada pela psicologia experimental, principalmente através da aplicação de testes psicológicos; 2) Uma política de simulação, resultado da atuação das neurociências a partir de processos de imageamento cerebral com tecnologias digitais e 3) Um política de metamorfose constituída nas práticas de pesquisa-intervenção. A metodologia desse processo segue a sugestão de Mol (2002), e investiga as sessões de métodos, materiais e procedimentos em artigos científicos. Essas sessões especificam o tanto quanto possível as práticas de investigação, o que reforça a ideia de que as práticas que permitem aos objetos se manifestar são cruciais para aquilo que pode ser dito deles.
A perplexidade como abertura do pensamento num “mundo fora dos eixos”
Authors: Neves José Mário d'Avila
Published: February 2020

O assombro e a perplexidade diante de uma “realidade brasileira” que parece “fora dos eixos” é o ponto de partida deste artigo, que problematiza os limites da nossa compreensão e busca entender o que as forças ultraconservadoras perceberam na realidade – que nós não tínhamos percebido –, que possibilitou a essas forças dirigirem os acontecimentos e assumirem as rédeas dos fluxos de produção da realidade. A demonstração de como o nosso sistema social chegou ao seu limite histórico – que evidencia o esgotamento das condições para integração pelo trabalho e coesionamento social pelas regras democráticas e pelas políticas públicas construídas ao longo do século XX – permite elucidar a nova dinâmica da realidade brasileira e explicar a radical guinada das elites brasileiras, que migraram da estratégia democrática de gestão negociada das contradições sociais para uma estratégia autoritária de gestão bélica dessas contradições.
PERFIL SOCIODEMOGRÁFICO DO CÂNCER DE MAMA NA BAHIA NOS ANOS DE 2013 A 2018
Authors: De Assis Elisandra Araujo , Barreto Maria da Luz , Lima Karen Bárbara Eloy
Published: February 2020

O câncer de mama trata-se de um tumor maligno que se desenvolve no tecido mamário. Este tipo de câncer é considerado raro em mulheres jovens com idade inferior a 40 anos, porém nessa população a doença cursa geralmente com pior prognóstico. Estudos apontam alta incidência de vítimas no Brasil, apresentando destaque também na saúde pública mundial. O objetivo do presente estudo é analisar o perfil sociodemográfico do câncer de mama na Bahia nos anos de 2013 a 2018. Trata-se de um estudo epidemiológico descritivo apresentando dados sobre o câncer de mama em mulheres de 5 a 80 anos ou mais, notificados no Sistema de Informações de Saúde (TABNET) dos Serviços de Morbidade Hospitalar do SUS (SIH/SUS) no CID-10, segundo Região de Saúde (CIR). Como resultado cita que foi identificado um total de 22.711 casos de mulheres com câncer de mama no período citado anteriormente, com maior predominância na faixa etária de 50 a 59 anos (6.191 casos), apresentando maior quantidade de casos no ano de 2018 (4.132 casos). A maioria dos dados foram apontados em mulheres de raça/cor de pele parda, totalizando 16.071 casos, e a maior incidência registrada é a de neoplasias malignas (20.940 casos, de 2013 a 2018). Com base nos dados obtidos, destaca-se a importância da notificação dos casos de câncer de mama no sistema do SUS, a fim de que verbas sejam disponibilizadas para investimentos em campanhas de prevenção e em exames que detectam o câncer em sua fase inicial.
A CULTURA DA DEPREDAÇÃO DO ÔNIBUS ESCOLAR: A EDUCAÇÃO FORMAL COMEÇA NO CAMINHO PARA ESCOLA
Authors: Sandes André Barreto
Published: February 2020

A sociedade contemporânea chegou a um nível de complexidade como nunca antes na historia e este fenômeno é um reflexo de uma nova dinâmica social que se manifesta no ritmo acelerado do mercado de trabalho, na crise de valores morais, na dificuldade de imposição de limites de alguns pais, na ausência de diálogo entre os membros da família e na influencia direta dos meios de comunicação. Diante desse cenário, as escolas devem incluir em seus projetos atividades que valorizem as relaciones saudáveis entre as pessoas e delas com o espaço que ocupam. Observando empiricamente a cultura de depredação dos ônibus que realizam o transporte escolar, especificamente os do programa “Caminho da Escola” no município de Laje, e escutando o depoimento dos motoristas em relação ao comportamento coletivo dos estudantes que os utilizam para se deslocar de sua residência para a escola sentiu-se a necessidade de se promover um debate em relação a essa problemática. Através de estudo de caso em três escolas do Ensino Fundamental II do município em questão, este trabalho tem como objetivo principal, proporcionar uma reflexão e quando possível una discussão a respeito dessa temática, destacando o cuidado com o transporte escolar que é onde a educação formal começa. Espera-se que os resultados desse estudo possam servir de ponto de partida para uma grande reflexão que seja capaz de sensibilizar os estudantes do município de Laje para que tenham mais atenção com o patrimônio publico, seja utilizando com cuidado ou fiscalizando, uma vez que zelar pelo bem comum é responsabilidade de todos.
First recorded co-occurrence of Valvata lewisi Currier, 1868 and Valvata lewisi ontariensis Baker, 1931 (Gastropoda: Valvatidae) from Alberta, Canada, with notes on morphometric and genetic variability
Authors: Hinchliffe Robert P. , Tebby Cheryl , Cobb Tyler P.
Published: February 2020

Sympatric populations of Loosely Coiled Valve Snail (Valvata lewisi ontariensis Baker, 1931) and Fringed Valvata (Valvata lewisi Currier, 1868) are documented from Alberta, Canada, for the first time. Both forms have been identified concurrently in aquatic invertebrate survey samples collected from three wetlands in northeastern Alberta by the Alberta Biodiversity Monitoring Institute. Molecular analysis (DNA barcodes) indicates that there is no genetic distinction between V. lewisi (sensu stricto) and V. lewisi var. ontariensis. Morphometric measurements show that the degree of open coiling, the character that defines V. lewisi var. ontariensis, is highly variable in Alberta specimens. Our findings confirm that V. lewisi var. ontariensis is a phenotypic morph of V. lewisi.
News and Comment
Authors: Lepitzki Dwayne
Published: February 2020

News and Comment
A note on the optimal parameters of USSOR method for solving linear least squares problems
Authors: Xu Peng-Bo , Zhang Nai-Min
Published: February 2020

For solving rank deficient linear least squares problems, unsymmetric
successive overrelaxation (USSOR) type methods are investigated by some
researchers recently. In this note, we continue to study the USSOR method
for solving rank deficient linear least squares problems and obtain the
optimal iteration parameters and the corresponding optimal convergence
factors. Numerical experiments are given to examine the feasibility and
effectiveness of the USSOR method with optimal parameters.
Remarks on fixed point theory in soft metric type spaces
Authors: Abbas Mujahid , Murtaza Ghulam , Romaguera Salvador
Published: February 2020

The aim of this paper is to discuss the recent development regarding fixed
point theory in soft metric type spaces such as soft G-metric spaces, soft
cone metric spaces, dislocated soft metric spaces and soft b-metric spaces.
We show that soft versions of fixed point results proved in such metric type
spaces can be directly deduced from the comparable existing results in the
literature.