bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling the Impact of Delaying Vaccination Against SARS-CoV-2 Assuming Unlimited Vaccines Supply
Authors: Massad Eduardo , Amaku Marcos , Covas Dimas Tadeu , Coutinho Francisco Antonio Bezerra , Azevedo Raymundo Soares
Published: June 2021

BackgroundAt the moment we have more than 109 million cases and 2.4 million deaths around the world and vaccination represents the only hope to control the pandemic. Imperfections in planning vaccine acquisition and difficulties in implementing distribution among the population, however, have hampered the control of the virus so far.MethodsWe propose a new mathematical model to estimate the impact of vaccination delay against the 2019 coronavirus induces disease (COVID-19) on the number of cases and deaths by the disease in Brazil. We apply the model to Brazil as a whole and to the State of Sao Paulo, the most affected by COVID-19 in Brazil. We simulated the model for the populations of the State of Sao Paulo and Brazil as a whole, varying the scenarios related to vaccine efficacy and compliance from the populations.ResultsThe model projects that, in the absence of vaccination, almost 170 thousand deaths and more than 350 thousand deaths until the end of 2021 for Sao Paulo and Brazil, respectively. If in contrast, Sao Paulo and Brazil had enough vaccine supply and so started a vaccination campaign in January with the maximum vaccination rate, compliance and efficacy, they could have averted more than 112 thousand deaths and 127 thousand deaths, respectively. In addition, that for each month of delay the number of deaths increases monotonically in a logarithm fashion, for both the State of Sao Paulo and Brazil as a whole.ConclusionsOur model shows that the current delay in the vaccination schedules that is observed in many countries has serious consequences in terms of mortality by the disease and should serve as an alert to health authorities to speed the process up such that the highest number of people to be immunized is reached in the shortest period of time.
Telocytes Promote Hepatocellular Carcinoma by Activating The ERK Signaling Pathway and miR-942-3p/MMP9 Axis
Authors: Xu Ying , Tian Hu , Luan Chao Guang , Sun Kai , Bao Peng Jin , Zhang Hua Yu , Zhang Nan
Published: June 2021

Background

In China, hepatocellular carcinoma (HCC) is considered a malignant tumor with poor prognosis, frequent metastasis, and a high relapse rate. Telocytes participate in tumorigenic, invasive, and migratory processes by secreting functional proteins and transmitting cell-to-cell information, but theirs functions in HCC are still unknown.
Methods

TC counts and MMP9 expression in liver cancer tissues were measured using immunohistochemistry, western blotting, and RT-PCR. Primary TCs from liver para-cancer tissues were cultured in vitro. To verify the role of TCs in HCC, a metastatic cancer animal model was established using 3 types of liver cancer cell lines in vivo.
Results

TCs promoted HCC cell metastasis by MMP9 expression in vitro and in vivo. Platelet derived growth factor-alpha (PDGF-α), secreted by HCC cells, activated the Ras/ERK signaling pathway in TCs, thereby increasing MMP9 expression; however, this had no significant effect on TC proliferation and apoptosis. miR-942-3p suppressed MMP9 expression in TCs.
Conclusion

Our results reveal the role of TCs in HCC and the mechanisms by which they elicit their effects, and they may serve as novel prognostic markers for HCC.
A molecular signature for the Metabolic Syndrome by urine metabolomics
Authors: Bruzzone Chiara , Gil-Redondo Rubén , Seco Marisa , Barragán Rocío , Cruz Laura de la , Cannet Claire , Schäfer Hartmut , Fang Fang , Diercks Tammo , Bizkarguenaga Maider , González-Valle Beatriz , Laín Ana , Sanz-Parra Arantza , Coltell Oscar , de Letona Ander López , Spraul Manfred , Lu Shelly C , Buguianesi Elisabetta , Embade Nieves , Anstee Quentin M , Corella Dolores , Mato José M , Millet Oscar
Published: June 2021

BACKGROUND. Metabolic syndrome (MetS) is a multimorbid long-term condition without consensual medical definition and a diagnostic based on compatible symptomatology. Here we have investigated the molecular signature of MetS in urine.METHODS. We used NMR-based metabolomics to investigate a European cohort including urine samples from 11,754 individuals (18–75 years old, 41% females), designed to populate all the intermediate conditions in MetS, from subjects without any risk factor up to individuals with developed MetS (4–5%, depending on the definition). A set of quantified metabolites were integrated from the urine spectra to obtain metabolic models (one for each definition), to discriminate between individuals with MetS.RESULTS. MetS progression produces a continuous and monotonic variation of the urine metabolome, characterized by up- or down-regulation of the pertinent metabolites (19 in total, including glucose, lipids, aromatic amino acids, salicyluric acid, maltitol, trimethylamine N-oxide, and p-cresol sulfate) with some of the metabolites associated to MetS for the first time. This metabolic signature, based solely on information extracted from the urine spectrum, adds a molecular dimension to MetS definition and it was used to generate models that can identify subjects with MetS (AUROC values between 0.86 and 0.92). This signature is particularly suitable to add meaning to the conditions that are in the interface between healthy subjects and MetS patients. Aging and non-alcoholic fatty liver disease are also risk factors that may enhance MetS probability, but they do not directly interfere with the metabolic discrimination of the syndrome.CONCLUSIONS. Urine metabolomics, studied by NMR spectroscopy, unravelled a set of metabolites that concomitantly evolve with MetS progression, that were used to derive and validate a molecular definition of MetS and to discriminate the conditions that are in the interface between healthy individuals and the metabolic syndrome.
Efficacy and Safety of Endoscopic Sleeve Gastroplasty versus Laparoscopic Sleeve Gastrectomy in Obese Subjects with non-alcoholic steatohepatitis (NASH): Study protocol for a randomised controlled trial (TESLA-NASH study)
Authors: LAVIN-ALCONERO LUCIA , FERNANDEZ-LANAS TATIANA , COZ PAULA IRUZUBIETA , ARIAS-LOSTE MARIA TERESA , DUQUE JUAN CARLOS RODRIGUEZ , RIVAS CORAL , CAGIGAL MARIA LUISA , MONTALBAN CORAL , USEROS ANTONIO LOPEZ , CANCELO ANA ALVAREZ , GARCIA-SAIZ MARIA DEL MAR , GARCIA JAVIER CRESPO
Published: June 2021

Background : Non-alcoholic steatohepatitis (NASH) is a growing public health problem that affects more than 5% of the population. The standard treatment is weight loss with diet and exercise, which has been shown a histological and analytical improvement in patients capable to achieve a 5-10% reduction in their body weight. However, less than 25% of subjects achieve this goal. Bariatric surgery (BS) is the treatment of choice for its efficacy in obese patients. This intervention has resolved NASH in 85% of cases. However, bariatric endoscopy (BE) is presented as a therapeutic alternative with good results in terms of efficacy, long-term weight loss, and safety, decrease of adverse events. Methods : The TESLA-NASH study is a randomized, controlled, open-label, unicentric clinical trial with a medical device. The aim of this study is to evaluate and compare the efficacy and safety of endoscopic sleeve gastroplasty (ESG) versus laparoscopic sleeve gastrectomy (LSG) in liver histology improvement of patients with obesity +/- metabolic syndrome and NASH. A total of 30 patients will be randomized 1:1 to the experimental or control group. Discussion : Gastric bypass surgery and restrictive surgical treatments have been successful improving metabolic syndrome, insulin resistance and liver histology of obese patients. Currently, endoscopic techniques which are less invasive, are being developed, showing fewer complications and lower sanitary cost, and gastric restrictions with similar characteristics to the traditional surgical method. The tubulization or vertical gastroplasty with the OverStitch system (Apollo Endosurgery, Austin, TX, USA) is one of the most promising one. However, currently, any method is accepted as a standard treatment for NASH. Trial registration : Clinical trial.gov: NCT04060368. Registred on 19 August 2019, https://clinicaltrials.gov/ct2/show/NCT04060368 Protocol version: v 2.0, dated 15 nov 2019.
Silibinin Promotes Bone Regeneration Through HIF-1α/VEGF and Notch Signaling Pathway in Ovariectomized Rats
Authors: Tao Zhoushan , Li Tian-Lin , Yang Min , Xu Hong-Guang
Published: June 2021

Objective

The purpose was to observe whether systemic administration with silibinin(SIL) have an positive effect on bone defect regeneration through HIF-1α/VEGF and Notch signaling pathway in an ovariectomized(OVX) rat model.
Methods

The MC3T3-E1 cells were co-cultured with lower SIL and higher SIL and induced to osteogenesis, and the cell viability, osteogenic activity were observed by Cell Count Kit-8(CCK-8), Alkaline phosphatase (ALP) staining, Alizarin Red(RES) staining and Western blotting(WB). After the drilling defect model was established, the OVX rats were treated with SIL for 12 weeks. Micro-CT, histology and Reverse transcription-quantitative polymerase chain reaction (RT-qPCR) analysis were used to observe the therapeutic effect and explore the possible mechanism.
Results

CCK-8, ALP and ARS staining results show that the cell mineralization and osteogenic activity of LSIL and HSIL group is significantly higher than the Con group. Protein expressions show that related regulatory proteins such as ALP, OPN, RUNX-2, OC, VEGFA, HIF-1α, Notch 1, JAG 1, HEY 1 and HES 1 of LSIL and HSIL group are significantly higher than Con group. Micro-CT and Histological analysis evaluation show that group SIL + OVX presented the stronger effect on bone regeneration, bone mineralization, higher expression of VEGFA and HIF-1α, when compared with OVX group. RT-qPCR analysis shows that SIL + OVX group showed increased Notch 1, HES1, HEY1 and JAG1 than the OVX group(p < 0.05).
Conclusions

Our current study demonstrated that systemic administration with SIL is a scheme for rapid repair of femoral condylar defects, and these effects may be achieved by activating HIF-1α/VEGF and Notch signaling pathway.
Contribution to the molecular taxonomy of cultivated populations of mastic trees on Chios Island
Authors: Kyriakidi Panagiota , Kostas Stefanos , Zeka-Paschou Constantina , Piliou Kleoniki , Mylona Antigoni , Vasileiadis Anastasios , Magklaras Panagiotis , Vasilakis Tilemaxos , Smyrnioudis Ilias , Hatzilazarou Stefanos , Afendra Amalia-Sofia , Economou Athanasios , Hatziloukas Efstathios
Published: June 2021

Background: The mastic tree (formal name: Pistacia lentiscus var. Chia) is extensively cultivated on the southern part of the Greek island of Chios. Its extensive cultivation is due to the production of a special resin, known as mastic gum, or mastiha, which is widely used in several dietary, pharmaceutical and other products since ancient times. Mastic tree is an evergreen, dioecious (consisting of male and female individuals), woody plant. Furthermore, a number of morphological characteristics suggest the existence of several different plant groups, called here “morpho-varieties”, but it is probable that there exist an unknown number of different, deviating genotypes on the island. Nevertheless, five major morphologically determined morpho-varieties of mastic tree are mainly cultivated, namely “Votomos”, “Maroulitis”, “Mavroschinos”, “Stenophyllos” and “Fardyphyllos”. The morpho-varieties exhibit mostly, but not always, distinct morphology, on which their taxonomy was initially based. Since it is observed that different plant populations differ in the quantity and quality of the produced resin, it is important to explore whether these differences have a genetic basis, or are due to other factors, such as agricultural practices, or soil composition. To this end, the genetic diversity among these five morpho-varieties and within each one of them was investigated in the present study, using in a first approximation their Random Amplified Polymorphic DNA profiles and subsequently the sequence divergence of their Internal Transcribed Spacer regions 1 and 2. Results: The results confirm the existence of a considerable genotypic diversity among the five morpho-varieties studied and, furthermore, reveal the existence of genotypic diversity within each one of them, as well as the existence of a number of further deviating genotypes. The possibility, this diversity to be partly a result of reticulate evolution events is also discussed.Conclusions: This study provides evidence that the population of cultivated mastic trees on the island of Chios consists mainly of two species, i.e. Pistacia lentiscus and Pistacia x saportae, although it is clear that there also exist genetically deviating mastic trees, as well as individual plants, probably produced through hybridization between the two afore mentioned species.
FINITE ELEMENT DISCRETIZATION OF THE BEAM EQUATION
Authors:   School of Mathematics and Actuarial Science, Maseno University P. O. Box-Private Bag Maseno-Kenya., Amakobe James Hagai
Published: June 2021

A beam is a structural element or member designed to support loads applied at various points along the element. Beams make up a structure which is an assembly of a number of elements. Beams undergo displacement such as deflection and rotations at certain important location of a structure such as centre of a bridge or top of a building. I haveanalysed numerically a two dimensional beam equation with one degree of freedom of the form using finite element method. The positive constant has the meaning of flexural rigidity per linear mass density, the beam deflection and is the external forcing term. This involved discretization of the beam equation employing Galerkins technique which yields a system of ordinary differential equations.
ECOLOGY OF NOSOCOMIAL INFECTIONS IN THE ENVIRONMENT OF RESUSCITATION OF SURGICAL EMERGENCIESABOUT 332
Authors:   Surgical Emergency Resuscitation Service., E. Soussane , Bouhouri A. ,   Surgical Emergency Resuscitation Service., Harrar R. ,   Surgical Emergency Resuscitation Service.
Published: June 2021

Nosocomial infection is any infection contracted in a healthcare establishment by any patient whose symptoms appear after 48 hours of hospitalization, 30 days for the operative site and one year in the case of an intervention. surgical Their high frequency, cost and severity make nosocomial infections a major health problem. Its surveillance is not an end in itself, it is designed as a means of guiding prevention, from which it must therefore gather the necessary information.
THE EGYPTIAN REVOLUTION OF 2011 AND ITS AFTERMATH IN EDITORIALS HEADLINES: CRITICAL DISCOURSE ANALYSIS OF THE REPRESENTATION OF EGYPT IN AMERICAN AND BRITISH MEDIA EDITORIALS
Authors: Echine Ayyad
Published: June 2021

The Arab world, starting from December 2010 onward, has witnessed unprecedented revolutions during which many long-lasting Arab leaders were unseated. Western media has allotted much coverage to the uprisings especially in nations, such as Egypt, with which the West, namely the U.S, shares mutual political ambitions in the Middle East. This study analyses a sample of 101 editorials headlines that were written, between 2011 and 2018, by the NYT, the WP, the Guardian and the Telegraph and suggests that these papers treatment of the revolutions is reflective of Orientalist conceptualizations that inferiorize Egypt and the Egyptians. The study draws on Edward Saids postcolonial model of Orientalism (1978) to make sense of the selected sample and targets two main areas in critical media studies quantitative content analysis and critical discourse analysis (CDA), to uncover whether or not the four newspapers editorials headlines are suggestive of Orientalist modes of thought. The study concludes that the coverage under scrutiny connects the West with the East in a way that is characterized by power relations wherein the West is having the upper hand, and thus producing a rhetoric that is stereotypical and Orientalist.
THE STYLISTIC PECULIARITIES OF THE SONG OF HIAWATHA BY H.W. LONGFELLOW IN ORIGINAL TEXT AND TRANSLATION
Authors:   Doctoral student of Samarkand State Institute of Foreign Languages., Umida Ruzimurodovna Elova
Published: June 2021

The article investigates the stylistic devices that are used in the plot of the poem of H.W. Longfellow The Song of Hiawatha and analyzes the ways of preserving them in translation versions. Theoretical content of the article is proved by examples of original extracts and their translation into the Uzbek language.
CAUSE DHEMORRAGIE POST PARTUM A LAQUELLE IL FAUT PENSER: PSEUDO-ANEVRISME DE LARTERE UTERINE APRES UNE CESARIENNE, A PROPOS DUN CAS
Authors:   Service De GynecologieObstetrique I CHU Hassan II Fes, Faculte de Medecineet dePharmacie de FES, UniversiteSidi Mohamed Ben Abdallah, Maroc., Mohamed Lemine Issehaghe Meimouna , Bouras Khadija ,   Service De GynecologieObstetrique I CHU Hassan II Fes, Faculte de Medecineet dePharmacie de FES, UniversiteSidi Mohamed Ben Abdallah, Maroc., Abdelkadr Mohamed Zeine Nessiba ,   Service De GynecologieObstetrique I CHU Hassan II Fes, Faculte de Medecineet dePharmacie de FES, UniversiteSidi Mohamed Ben Abdallah, Maroc., Mamouni Nisrine ,   Service De GynecologieObstetrique I CHU Hassan II Fes, Faculte de Medecineet dePharmacie de FES, UniversiteSidi Mohamed Ben Abdallah, Maroc., Errarhay Sanae ,   Service De GynecologieObstetrique I CHU Hassan II Fes, Faculte de Medecineet dePharmacie de FES, UniversiteSidi Mohamed Ben Abdallah, Maroc., Bouchikhi Chahrazed ,   Service De GynecologieObstetrique I CHU Hassan II Fes, Faculte de Medecineet dePharmacie de FES, UniversiteSidi Mohamed Ben Abdallah, Maroc., Aziz Banani Abdel ,   Service De GynecologieObstetrique I CHU Hassan II Fes, Faculte de Medecineet dePharmacie de FES, UniversiteSidi Mohamed Ben Abdallah, Maroc., Aassouani Farid ,   Service De Radioligie, CHU Hassan II de Fes., Maaroufi Moustapha ,   Service De Radioligie, CHU Hassan II de Fes.
Published: June 2021

Pseudoaneurysm of the uterine artery is a rare and poorly understood complication of Caesarean section or endocavitary manipulation. It can be responsible for severe postpartum hemorrhage, most often secondary or retarded. We present here a case of pseudoaneurysm of the left uterine artery diagnosed and treated in the gynecological-obstetrics department I, CHU HASSAN II DE FES. The diagnosis was guided by ultrasound but uterine arteriography of the uterine arteries remains a determining factor in establishing and making the diagnosis and also guiding the treatment.Selective arterial embolization was the treatment of choice. It has excluded the lesion, but vascular ligature or hysterectomy may be necessary if the patient is hemodynamically unstable.
INFLUENCE OF SUBSTANCE ABUSE ON CONTRACEPTIVE USE AMONG UNDERGRADUATE STUDENTS
Authors: Eldah Ochieng Obrenyi , Arudo John
Published: June 2021

Studies have shown a relationship betweendrinking and ineffective contraception and condom use. The rate of binge drinking and ineffective contraception or ineffective condom use among college women was proved to be high. This article examined the influence of addictive behavior on utilization of contraceptives among undergraduate students. Addictive factors that were compared with utilization included attending club and parties, alcohol consumption, and smoking. The data used in analysis was based on stratified probability sample of 453 respondents interviewed in 2017 from Masinde Muliro University of Science and Technology (MMUST). Quantitative and qualitative data was analyzed using descriptive statistics. The study revealed that there was a statistical significant relationship between respondent who frequently attended clubs and parties and contraceptives utilization (OR=0.48 95%CI 0.27-0.84, p=0.01). However, patronizing clubs and parties frequently reduced the probability of using contraceptives by 48% compared to those who did not frequent clubs or parties. Also, alcohol consumption was significantly associated with contraceptives utilization (OR=0.33: 95%CI 0.18-0.59, p=0.00). This result also revealed that respondents who consumed alcohol were 0.33 times less likely to use contraceptives than those who did not indulge in alcohol. Smoking was not statistically significantly associate with contraceptive utilization (p=0.85). The article recommends that HIV and AIDS peer educators should be tasked with educating on sexual and reproductive health and the importance of implementing specific programs in institutions of higher learning to limit the risks of addiction and partying, not only in terms of alcohol abuse, but also addictive behavior such as smoking.
HYPERTENSION INTRA CRANIENNEBENIGNE IDIOPATHIQUE ET GROSSESSE : A PROPOS DUN CAS
Authors:   Service De Gynecologie-Obstetrique I / Chu Hassan Ii Fes-Maroc., Samory Khatry O. , Karam S. ,   Service De Gynecologie-Obstetrique I / Chu Hassan Ii Fes-Maroc., Mamouni N. ,   Service De Gynecologie-Obstetrique I / Chu Hassan Ii Fes-Maroc., Errarhay S. ,   Service De Gynecologie-Obstetrique I / Chu Hassan Ii Fes-Maroc., Bouchikhi C. ,   Service De Gynecologie-Obstetrique I / Chu Hassan Ii Fes-Maroc., Banani A. ,   Service De Gynecologie-Obstetrique I / Chu Hassan Ii Fes-Maroc.
Published: June 2021

Lhypertension intracranienne idiopathique (HTICI) est une pathologie rare, sa physiopathologie reste encore difficile a expliquer. Le diagnostic positif repose sur des signes cliniques dHTIC, une imagerie cerebrale normale, et une mesure de la pression du LCR. Le diagnostic dHTICI est retenu selon les criteres de Dandy modifies par FRIEDMAN et JACOBSON. Sa survenue durant la grossesse entraÃ®ne plusieurs difficultes du diagnostic positif, car les cephalees sont frequemment rencontrees chez la femme enceinte et leurs causes sont multiples. Le choix de la therapeutique depend en premier lieu de latteinte visuelle, mais aussi de lage gestationnel, la grossesse nest pas contreindiquee chez une patiente atteinte de cette pathologie, lhypertension intracranienne idiopathique naugmente pas le taux de complications obstetricales, et laccouchement peut se realiser dans les conditions habituelles. Nous rapportons le cas dune patiente ayant presente une HTIC idiopathique diagnostiquee au troisieme trimestre de sa grossesse. Lobjectif de cet article est de preciser les modalites de prise en charge, levolution et le pronostic obstetrical de cette pathologie.
OBSTACLES ENCOUNTERED WHILE DEALING WITH EMERGENCY CASES BY PRIMARY HEALTH CARE PHYSICIANS IN CLUSTER 1 RIYADH CITY, KINGDOM OF SAUDI ARABIA
Authors: M. Alazmi Alhanouf , Zouheir Mbarki Fathi , Ahmed Sharahili Abeer , Ahmed Ghzwany Amal , Ali Alhwsawi Esra
Published: June 2021

Background: The frontline primary healthcare centers (PHCCs) are regularly visited for different medical problems, ranging from minor situation to emergency cases. The frontline primary healthcare centers (PHCCs) are regularly visited for different medical problems, ranging from minor situation to emergency cases. Therefore, analytical cross-sectional study was conducted to assess nature of encountered acute medical emergencies, self-perception and competencies of PCH physicians dealing with them, and, sufficiency of the required PHCCs equipment in hospitals of Riyadh. Methodology: This cross-sectional study enrolled all the physicians in governmental PHCCs, Ministry of Health (cluster 1) Riyadh city during the study period. The study was conducted using modified previously validated online accessible questionnaire. Online questionnaire was distributed across the selected Primary health care centers in Riyadh by submitting it to PHC manager to distribute to all PHC physicians during study period Results: In this study, we were able to collect 206 responses for our questionnaire among primary healthcare physicians. Among these physicians 58.8 % were aged between 25-35 years old and 55.3 % were females. We found that the percentage of PHC physicians who will attempt to perform the assessed skills for all patients did not exceed 30%. The least cases seen by physicians were cardiac arrest, acute GIT bleeding, anaphylaxis and acute vaginal bleeding which never seen during the last year by 83.1 %, 72.8 %, 70.9 % and 68 % of participants respectively. Conclusion: The current study showed that emergency services at the PHC level in Riyadh, Saudi Arabia are not functioning reasonably in some terms. Therefore, the services need to be perfected, and defects revealed by the current study should be taken into consideration hand-in-hand with available resources to upgrade the quality of the emergency services provided at PHC centers in Riyadh.
PULSATILE DRUG DELIVERY SYSTEM-A TECHNIQUE OF DELIVERING DRUG IN ACCORDANCE WITH BIOLOGICAL CLOCK - A REVIEW
Authors:   Student In Institute Of Pharmaceutical Sciences And Technologies Jntuk Kakinada., Vani Chiluvuru , Srinivas Reddy K. ,   Student In Institute Of Pharmaceutical Sciences And Technologies Jntuk Kakinada.
Published: June 2021

Over last 30 years pulsatile drug delivery system has achieved a lot of importance in drug delivery technology. And the reason why this pulsatile drug delivery is gaining importance is because of its strategy of delivering drug molecule at right place, right time. There are certain diseases which are controlled by biological clock of our body and follow circadian rhythms like congestive heart failure, asthma, rheumatoid arthritis ,osteoarthritis, inflammatory disorders and other hormonal disorders, for this type of diseases conventional solid dosage forms like immediate release tablets or modified dosage forms like sustained, controlled release tablets cant give the required therapeutic response and also for such diseases delivering the drug at right time in right amount is very important. And that task is accomplished by this pulsatile drug delivery system. These pulsatile drug delivery framework is planned by the organic mood i.e., biological rhythms of the body, and medication conveyance is worked with by as per disease cadence. The rule for the utilization of pulsatile drug delivery of the medications is the place where a consistent drug discharge isnt wanted. The principle for the utilization of pulsatile release of the medications is the place where a steady drug discharge isnt wanted, yet drug release must be planned in such a way that, quick medication discharge is accomplished after the lag time. Current review examined the clarifications for improvement of pulsatile drug delivery framework in accordane with body circadian rhythm, kinds of the illness during which pulsatile discharge is required, order, assessments, benefits, impediments.
CURRENT SITUATION OF TRAINING AND FOSTERING OF ETHNIC MINORITY STAFFS IN VIETNAM
Authors:   Bac Lieu Province, Viet Namese., Hoang Khai Tran
Published: June 2021

Being home to a diversity of 54 ethnic groups, Vietnam has attached great significance to training and fostering ethnic minority staff during its national development. The Document of the 7thConference of the 9thCentral Committee of the Communist Party of Vietnam on ethnic affairs emphasized the need to build a contingent of qualified ethnic minority staff meeting local requirements and well execute the planning, training, fostering, and employment of ethnic minority staff for each region. This special attention illustrates a consistent view on the realization of equality and solidarity among the ethnic groups sharing the territory of Vietnam.
SPECTRUM OF MUSCULOSKELETAL DISCOMFORTS IN PREGNANT WOMEN AND IMPACT OF ANTENATALEXERCISES OR POSTURAL CARE ON THE STATUS OF RELIEF: A SYSTEMATIC REVIEW STUDY
Authors:   Asst. Professor Department of Physiotherapy, UIHS, CSJM University, Kanpur., Shukla Neha , Shukla Puja ,   MPT Research Scholar.
Published: June 2021

Pregnancy is a normal physical state of womens life when they carried a 9 month developmental stages of the foetus. On these durations some pregnancy induced changes leads normal signs naturally but there is an increased risk of musculoskeletal pain or discomforts associated with increase of uterine size and mental stress of pregnant women, needed non-medicines approached like antenatal physiotherapy care. These possible pain or discomforts can make difficult to carry the pregnancy may leadsome complications. Various research studies have been pointed out these problems of pregnant women and found out the triggers. Some studies show the spectrums of these musculoskeletal problems during pregnancy period. Various case studies are assured to theparticular physiotherapy techniques as antenatal exercises have good impact on relief of respective Musculo-skeletalpain. Various researches have also covered some other aspects of Musculo-skeletal problems during pregnancies. In thepresent study an attempt has been made to comprehensive analysis of these review studies to identify the most common musculoskeletal problems in different stages of pregnancy and efficacy of physiotherapy techniques and antenatal exercises to overcome the problem.It was found in the spectrum analysis that most of the women (68.33 %) faced this problem during their pregnancy. On the analysis of most commonmusculoskeletal problem, the mean percent of reviews reveals showed that the most of the women found to be in muscle cramps and pain in neck and shoulder during I trimester whereas maximum women had low back pain (42.87 %) and pelvic girdle pain (11.65 %) on II and IIItrimesters respectively. The satisfactory impacts of antenatal exercises were observed in different musculoskeletal pain by different techniques of Physiotherapy.These results can utilize to make suggestions and recommendations foradoption of suitable physiotherapy techniques in pregnancy to avoid the problem.
THE DEVELOPMENT OF INTEGRATED THEMATIC TEXTBOOK WITH THEME MY IDEALS AND SUB-THEME ME AND MY IDEALS BASED ON CURRICULUM 2013
Authors:   Department of Elementary School Teacher Education, Indonesia Open University., Makhfiyah Lilik , Sulthon Masyhud M. ,   Department of Elementary School Teacher Education, The University of Jember., Imam Farisi Mohammad ,   Department of Elementary School Teacher Education, Indonesia Open University.
Published: June 2021

This study aimed to develop a textbook for fourth grade elementary school students. This research applied research-and-development model adapted from Borg & Gall. The developmentinvolved the following steps (1) initial research and information gathering, (2) textbook planning, (3) product validation testing, (4) product revision, (5) product testing. The research data was obtained through documentation, interviews, questionnaires, validation sheets and learning achievement tests after a product trial had been carried out with 2 classes, namely the experimental class and the control class. The data were then analyzed using the t-test technique and the relative effectiveness test. The results of the independent t-test obtained t value -5.551 and showed significant differencewith p 0.000. The significance value was smaller than Î± value (0.05). This means that there is an average difference between the control class and the experimental class. The calculation of the relative effectiveness obtained a value of 57.24%, so it can be concluded that the textbook developed have a relative effectiveness level of 57.24% compared to the previous textbook.
EXAMINING THE INCIDENCE OF CANDIDA ALBICANS AND TRICHOMONAS VAGINALIS AMONG PREGNANT WOMEN IN RURAL COMMUNITIES OF KOGI STATE
Authors:   Department of Biology, Kogi State College of Education, Ankpa., Abuh Simon , Melinga Salifu ,   Department of Biology, Kogi State College of Education, Ankpa.
Published: June 2021

Candida albicans and Trichomonas vaginalis are Candida albicans and Trichomonas vaginalis are fungal infections that are raising health concerns. The studys objective was to examine the incidence of C. albicans and T. vaginalis infections among pregnant women in the rural communities of Kogi state. A total of three hundred and thirty-six women who attends antenatal care in public health institutions participated in the study. The study samples were pooled from the participants through their consulting physicians. The Analysis conducted on the samples showed that 61.3% of the total samples tested positive for C. albicans, 5.1% tested positive for T. vaginalis, and 33.6% were negative for both infections. However, no co-occurrence was reported. The study concludes that the disease is prevalent in Kogi state and recommends a robust enlightenment approach.
IDENTIFICATION OF SOCIAL AND ENVIRONMENTAL RESPONSIBILITIES BY THE PUNAGAYA STEAM POWER PLANT (PLTU) CASE STUDY (IN JENEPONTO DISTRICT)
Authors:   Faculty Of Law Universitas Pembangunan NasionalVeteran Jakarta-Indonesia., Wahyono Ruslan , Arafah Sinjar Muhammad ,   Doctoral of Law at the Faculty Of Law Universitas Pembangunan Nasional Veteran Jakarta-Indonesia.
Published: June 2021

The purpose of this study was to determine the views of the community on the implementation of environmental responsibility and efforts to improve the communitys economy through Corporate Social Responsibility carried out by the Punagaya Steam Power Plant (PLTU). This type of research is juridical empirical. Empirically this research was conducted by looking at a law implementation in society. Based on the research results obtained by the results of the questionnaire by 41 respondents based on a Likert scale with a total score of B x F of 101, it can be concluded that the implementation of environmental responsibility is less effective because of environmental pollution and infrastructure development that is not optimal. As for the publics view of efforts to improve the communitys economy through Corporate Social Responsibility based on the results of a questionnaire having a total score of B x F of 118, it can be concluded that these activities are quite effective.The program in the socio-economic field are realized in the form of providing food assistance to residents around the Punagaya PLTU, providing clean water during the dry season, utilizing local labor during construction and operational periods, assistance for youth organization activities and emergency response in the form of the use of the Fire Fighting.
A STUDY OF USE OF INTERNET OF THINGS AND MACHINE LEARNING IN SMART WASTE MANAGEMENT
Authors:   Student, Computer Engineering Department, A.I.S.S.M.S. College of Engineering, Pune., Kulkarni Aashay , Mahajan Manas ,   Student, Computer Engineering Department, A.I.S.S.M.S. College of Engineering, Pune., Mali Shantanu ,   Student, Computer Engineering Department, A.I.S.S.M.S. College of Engineering, Pune., Shelar Yash ,   Student, Computer Engineering Department, A.I.S.S.M.S. College of Engineering, Pune., Pradhan Madhavi ,   Associate Professor, Computer Engineering Department, A.I.S.S.M.S. College of Engineering, Pune.
Published: June 2021

Waste Management poses a big challenge in front of many Municipalities. The fixed routes and schedules of garbage collection are not that efficient. The monitoring of dustbins is also difficult since the number of such is large. Inclusion of Internet of Things and Machine Learning helps in improving the efficiency and makes the work easier for authorities. A lot of work has been done in this field and this article presents the various approaches used by various fellow researchers. The main contribution of this article is that it puts forward an architecture that can be used in the future. This study will help the researchers who want to quickly look at the work done till now in this field and investigate what can be done further.
METACOGNITIVE APPROACH TO ENHANCING MATHEMATICAL PERFORMANCE AMONG PRIMARY SCHOOL STUDENTS IN RURAL AND URBAN AREAS OF KOGI STATE
Authors:   Department of Mathematics, Kogi State College of Education, Ankpa., Okpanachi David , A. Umoru Samuel ,   Department of Mathematics, Kogi State College of Education, Ankpa.
Published: June 2021

In this study, a quasi-experimental design was employed to ascertain the effect of the metacognitive instruction approach on primary school students mathematical performance in Kogi State. A total of seventy-two students with an age range of 7 â€“ 11 years and a mean age of (M=9.12), (SD= 1.22) participated in the study. The participants were grouped into two and were subjected to a pre-test and post-test study. Mean, and standard deviation scores were used, and an independent t-test analysis conducted on the data established a statistically significant difference between the groups, MD = 11.54 (95% CI, 7.91 to 15.14), t (70) = 6.313, p = .001. Thus, the result supported the studys hypothesis. It was concluded that metacognition is effective in enhancing students mathematics performance. The studyrecommends that teachers be regularly trained on the use of the metacognitive approach in the classroom.
PHYTOCHEMICAL ANALYSIS AND MEDICINAL VALUE OF MONODURA MYRISTICA SEED
Authors:   Department of Chemistry, Kogi State College of Education, Ankpa., B. Ejeh John
Published: June 2021

The purpose of the present study was to analyze the phytochemicals of M. myristica. The ground sample was soaked for 24 hrs with different solvents in other to extract the medicinal component. The qualitative analysis shows the positive result insaponin, glycoside, steroid, and alkaloid, while flavonoid and Tannin are negative. The quantitative analysis for M. myristicaseed show 32% to saponins, alkaloid 8.35%, phenol 55.7%, flavonoid 0.0707 mg/ml, and glycoside 5.2% while-tannin is negative. The result shows that M. myristicacan be used to produce vaccines because of saponin, while flavonoids were found to be the biological and pharmacological activities, including antioxidant.
THE INFLUENCE OF KNOWLEDGE OF BASIC ECOLOGICAL CONCEPTS ON ALTRUISTIC BEHAVIOR TOWARDS THE ENVIRONMENT
Authors:   Universitas Satya Negara Indonesia., Sapta Dewi Yusriani
Published: June 2021

Eco-friendly behavior conceptualized as altruistic behavior is a response that gives positive feeling and gives positive impact to the environment. Altruistic behavior does not come from nothing, instead it comes through knowledge that a person possesses, experience, and so on. This study aims to obtain information about the influence of knowledge of basic ecological concepts on altruistic behavior towards the environment. This study used survey method with correlational techniques through quantitative approach. Respondents in this study were students of Universitas Satya Negara Indonesia, who were selected through simple random sampling. The data was collected using a Likert scale questionnaire. The data then analyzed using correlation regression, while regression significance and linearity were analyzed using ANAVA test. The results showed that there is a very significant relationship between knowledge of basic ecological concepts with altruistic behavior towards the environment. In other words, the better the knowledge of basic ecological concepts, the higher their altruistic behavior will be.
NOVO ADSORVENTE NANOESTRUTURADO HÍBRIDO DO TIPO AMINA/KIT-6 PARA CAPTURA DE CO2
Authors: Fernandes Fernando , Pinto Francisco , Villarroel-Rocha Jhonny , Sapag Karim , Souza Luiz , Caldeira Vinícius , Santos Anne
Published: June 2021

NEW HYBRID NANOSTRUCTURED ADSORBENT TYPE AMINE/KIT-6 FOR CO2 CAPTURE. The present work functionalized KIT-6 mesoporous material with aminopropyltrimethoxysilane (APTMS) and tested its efficiency in CO2 capture. The KIT-6 material was synthesized by hydrothermal method and functionalized via excess solvent in APTMS concentrations of 5 and 15% to obtain the hybrid adsorbents. All adsorbent materials were characterized by XRD, TGA/DTGA, DSC, N2 adsorption/desorption, SEM and applied in the CO2 capture, varying the temperature and pressure. The KIT-6 mesoporous structure at the hybrid adsorbents was kept. Variations in textural properties denoted that the organic molecules were incorporated in mesoporous structure. In the experiments, both chemisorption and physisorption were observed, reaching the best values at 25 ºC, indicating that the temperature influences the adsorption process. The experiments showed adsorbed amounts of up to 0.8 mmol/g at atmospheric pressure, displaying the efficiency of the chemisorption provided by the CO2 interaction with the hybrid adsorbents. At high pressures, a predominance of physisorption was observed, demonstrating a better performance for the KIT-6 support, due to the superior textural properties. Finally, a well-ordered and functional hybrid adsorbent was successfully developed for the adsorption of carbon dioxide
The cadastral value as a tool for monitoring the real estate market value
Authors:   St. Petersburg State University, Gadasina Lyudmila , Laskin Mikhail ,   St. Petersburg Federal Research Center of the Russian Academy of Sciences, Zaytseva Ekaterina ,   LLC “Wrike Ru”
Published: June 2021

In the theory and practice of real estate valuation, in analytical studies of the dynamics of real estate markets there is a problem of tracking changes in market prices. The apparent simplicity of this task leads to the fact that in everyday practice both market participants and professional analysts are satisfied with observations of average prices. The advantage of this traditional approach is computational simplicity. However, in the conditions of presence of a large number of special software and extensive statistical material can be used more complex research methods. The purpose of this article is to research big current market data of real estate objects and compare these data with the cadastral value determined in accordance with Russian legislation as the market value at the specified date. In this regard, there are problems associated with the multidimensional distribution of market prices and cadastral values. The article presents the method of calculation of changes of the real estate market prices on the basis of comparison of two-dimensional prices distributions of offers and cadastral prices for two periods. The main problem in studying the dynamics of real estate market prices is the inability to track the change in market prices for each property, as objects are constantly put up for sale and removed from it. The work carried out in the Russian Federation in 2014 to establish the cadastral value of real estate opens opportunity to analyze two-dimensional distributions of current market and cadastral prices and to assess the dynamic characteristics of the market for any real estate objects. The main result of article is the method which allows to apprise the market value of real estate in real time when new market data come by their comparison with the previously established cadastral value. Cadastral value is assumed to be defined as market value at the valuation date.
The evaluation of the effectiveness of high-dividend strategies in Asia-Pacific Economic Cooperation economies
Authors:   National Research University Higher School of Economics, Stolyarov Andrey , Sorokin Ilya ,   National Research University Higher School of Economics,   Russian Foreign Trade Academy
Published: June 2021

Investment strategies related to the use of high-dividend shares have been known for more than 30 years. Despite this, they remain relevant today. A large number of studies on this topic are devoted to studying the effectiveness of high-dividend strategies within one market, and cross-country studies evaluate a small number of markets. The aim of this paper is to evaluate the effectiveness of high-dividend strategies in the markets of all APEC economies, with the exception of Brunei and Papua New Guinea. The time horizon of the study is from 2002 to the present. We applied well-known modifications of the classic high-dividend strategy and modifications developed by the authors. We test hypotheses regarding the influence of various factors, such as the number of shares in a portfolio, the month of portfolio formation,classifying the economy as developed or developing, and the return on high-dividend portfolios. We also test the hypothesis that the significance of the high-dividend anomaly exists in various markets, but decreases over time. The results show different levels of effectiveness of high-dividend strategies and the different impact of the factors on the markets of developed and developing APEC economies. We found that high-dividend strategies are generally more effective in emerging markets, but in case of market growth, high-dividend strategies increase their abnormal returns only in developed markets. At the same time, the authors conclude that the number of shares in a high-dividend portfolio directly affects the result of its work. The results have theoretical and practical value, and can be applied in compiling a real investment portfolio.
Natural Substances in the Fight of SARS-CoV-2: A Critical Evaluation Resulting from the Cross-Fertilization of Molecular Modeling Data with the Pharmacological Aspects
Authors: Gentile Davide , Patamia Vincenzo , Fuochi Virginia , Furneri Pio M. , Rescifina Antonio
Published: June 2021

The recent pandemic due to SARS-CoV-2, the last isolated human betacoronavirus,
has revolutionized modern knowledge of the pathogenesis of viral pneumonia.
The lack of specific antiviral drugs and the need to develop adequate research for new antiviral
drugs capable of treating this new form of the disease undertook three different research
paths quickly. The first one is aimed to test antiviral molecules already present in
therapeutic use, with a mechanism of action directed towards viral proteins functional to
replication or adsorption; the second one, it is the repositioning of molecules with known
pharmacological activity for which various chemistry studies have been prepared in an attempt
to find new and specific viral targets; the third, it is the search for molecules of natural
origin for which to demonstrate a specific anti-coronavirus activity. Many databases of
natural and synthetic substances have been used for the identification of potent inhibitors of
various viral targets. The field of computer-aided drug design seems to be promising and
useful for the identification of SARS-CoV-2 inhibitors; hence, different structure- and ligand-
based computational approaches have been used for their identification. This review
analyzes in-depth and critically the most recent publications in the field of applied computational
chemistry to find out molecules of natural origin with potent antiviral activity. Furthermore,
a critical and functional selection of some molecules with the best hypothetical
anti-SARS-CoV-2 activity is made for further studies by biological tests.
New Small-molecule Analgesics
Authors: Laev Sergey S. , Salakhutdinov Nariman F.
Published: June 2021

Pain is a symptom of ninety percent of human diseases, and pain management is a
very important medicinal problem. Various modulators of the pain response have been detected,
and analgesic effects are obtained by increasing inhibition or decreasing excitation in
the nervous system. Various known analgesic drugs are commonly used to relieve the pain;
however, this problem is still not fully resolved by currently available treatments. Available
analgesic drugs (non-steroidal anti-inflammatory drugs, opioids and analgesic adjuvants) are
not too effective and are severely limited by adverse effects, for example, opioid addiction.
Therefore, developing effective pain management is a difficult but necessary task. Thus,
there is an urgent need for further development of the design and synthesis of new analgesic
agents. The aim of this review is to present recent progress in search of new small molecule
analgesics. The structures and effects of new perspective analgesic agents (anti-inflammatory
agents, opioid analgesics, adjuvant agents for pain management, and natural compounds) are
presented and discussed. The review covers the literature published in 2015-2020 years and
includes 173 references.