bluuebunny/crossref_metadata_2025 huggingface dataset:
Inequality and Influencing Factors of Spatial Accessibility of Medical Facilities in Rural Areas of China: A Case Study of Henan Province
Authors: Liu Shirui , Qin Yaochen , Xu Yanan
Published: May 2019

The equalization of medical services has received increasing attention, and improving the accessibility of medical facilities in rural areas is key for the realization of fairness with regard to medical services. This study studies the rural areas of Henan Province, China, and uses unincorporated villages as the basic unit. The spatial pattern of accessibility in rural areas was comprehensively analyzed via geographic information system spatial analysis and coefficient of variation. The spatial heterogeneity of relevant influencing factors was assessed by using the geographically weighted regression model. The results show that: (1) The distance cost of medical treatment in rural areas is normally distributed, and most areas are within a range of 2–6 km. (2) The accessibility in rural areas has clear spatial differences, is significantly affected by terrain, and shows characteristics of significant spatial agglomeration. The eastern and central regions have good spatial accessibility, while the western regions have poor spatial accessibility. Furthermore, regions with poor accessibility are mainly located in mountainous areas. (3) The spatial equilibrium of accessibility follows a pattern of gradual deterioration from east to west. The better accessibility-unbalanced type is mostly located in the center of Henan Province, while the poor accessibility-unbalanced type is concentrated in mountainous areas. (4) The area, elevation, residential density, and per capita industrial output are positively correlated with spatial accessibility, while road network density and population density are negatively correlated.
Stakeholder Attitudes towards Donating and Utilizing Donated Human Breastmilk
Authors: Lubbe Welma , Oosthuizen Charlene S. , Dolman Robin C. , Covic Namukolo
Published: May 2019

The promotion and support of human milk banks (HMBs) can enhance exclusive breastfeeding rates. The success and sustainability of HMBs depend on the support from relevant healthcare workers and related communities. This study aimed to determine attitudes of key stakeholders, including mothers, healthcare workers and grandmothers, regarding the donation and receipt of human breastmilk. This study was conducted at a public hospital and clinics in the North West Province, South Africa. Eight focus group discussions explored the attitudes regarding donating and receiving human breastmilk: three groups with mothers of infants (n = 13), three with grandmothers (>60 years old) (n = 17) and two with healthcare professionals working with infants (n = 11). Four main themes emerged: perception regarding breast and formula feeding; exposure to the concept of “wet nursing”; breastmilk donation; and utilization and opinions of community members and traditional healers. Specific barriers identified included the processes for donating and receiving milk, safety, human immuno-deficiency virus (HIV) screening and cultural beliefs. Mothers’ fears included having insufficient milk for their own infants, changes in the quality of donated milk during pasteurization and transportation and HIV transmission. Despite barriers towards donations to and the use of HMBs, sufficient information could enhance donations by mothers and breastmilk utilization.
Active Commuting to and from School, Cognitive Performance, and Academic Achievement in Children and Adolescents: A Systematic Review and Meta-Analysis of Observational Studies
Authors: Ruiz-Hermosa Abel , Álvarez-Bueno Celia , Cavero-Redondo Iván , Martínez-Vizcaíno Vicente , Redondo-Tébar Andrés , Sánchez-López Mairena
Published: May 2019

Background: Physical activity has a beneficial effect on the brain’s development process and cognitive function. However, no review to date has evaluated the effects of active commuting to and from school (ACS) on cognitive performance and academic achievement. The aim of this systematic review and meta-analysis was to evaluate the link between ACS and cognitive performance and academic achievement in children and adolescents. Methods: We systematically searched MEDLINE, EMBASE, Web of Science and PsycINFO databases for all observational studies published until May 2019 that examined the association between ACS and cognitive performance or academic achievement. Studies were classified into two groups according to their measured outcomes: cognitive performance (nonexecutive cognitive functions, core executive functions, and metacognition) and academic achievement (marks of different areas). A pooled effect size (ES) was estimated using the DerSimonian and Laird random-effects method for cognitive performance and each area of academic achievement. Results: Twelve studies that evaluated the relationship between ACS and cognitive performance or academic achievement were included in the systematic review: four studies analyzed both cognitive performance and academic achievement, one study provided data regarding cognitive performance and seven provided data on academic achievement. Finally, nine of 12 studies provided enough data for inclusion in the meta-analysis. Our findings suggest that ACS was not significantly associated with cognitive performance (ES = −0.02; 95% CI: −0.06 to 0.03) or academic achievement (ES = −0.33; 95% CI: −0.83 to 0.17 for mathematics-related skills; ES = −0.37; 95% CI: −0.88 to 0.15 for language-related skills). Conclusions: There was insufficient evidence regarding the relationship between ACS and cognitive performance and academic achievement. Future studies should include potential confounders in their analyses and consider the use of standardized self-reports or objective measures of ACS.
The Effects of Locus of Control, Agents of Socialization and Sport Socialization Situations on the Sports Participation of Women in Taiwan
Authors: Huang Hsiu-Chin , Liu Li-Wei , Chang Chia-Ming , Hsieh Huey-Hong , Lu Hsin-Chi
Published: May 2019

Compared to men, the sports participation of women is lower, especially in the East. Not many studies have compared the impacts of locus of control, agents of socialization, and sport socialization situations on the sports participation of women. Hence, the purpose of this study is to explore the contributing factors which may promote the sports participation of women in Taiwan. To do this, 450 structured questionnaires were distributed to women in Chiayi, Taiwan, with an 89.3% return rate. The study found that internal locus of control, agents of socialization, and sport socialization situation had positive impacts on the sports participation of women. In line with these results, the study suggests the strengthening of the internal locus of control of women, making the best use of socialization agents, and improvement of sport socialization situations, in order to promote sports participation in women.
Heavy Metals in Suspended Particulate Matter of the Zhujiang River, Southwest China: Contents, Sources, and Health Risks
Authors: Zeng Jie , Han Guilin , Wu Qixin , Tang Yang
Published: May 2019

To investigate the abundance, water/particle interaction behavior, sources, and potential risk of heavy metals in suspended particulate matter (SPM), a total of 22 SPM samples were collected from the Zhujiang River, Southwest China, in July 2014 (wet season). Nine heavy metal(loid)s (V, Cr, Mn, Ni, Cu, Zn, As, Cd and Pb) in SPM were detected. The results show that the selected heavy metal(loid)s in SPM appear in the following order: Mn (982.4 mg kg−1) > Zn (186.8 mg kg−1) > V (143.6 mg kg−1) > Cr (129.1 mg kg−1) > As (116.8 mg kg−1) > Cu (44.1 mg kg−1) > Ni (39.9 mg kg−1) > Pb (38.1 mg kg−1) > Cd (3.8 mg kg−1). Furthermore, both the enrichment factor (EF) and geo-accumulation index (Igeo) indicate that SPM is extremely enriched in metal(loid)s of Cd and As, while SPM is slightly enriched, or not enriched, in other heavy metals. According to the toxic risk index (TRI) and hazard index (HI), arsenic accounts for the majority of the SPM toxicity (TRI = 8, 48.3 ± 10.4%) and causes the primary health risk (HI > 1), and the potential risks of V and Cr are also not negligible. By applying a correlation matrix and principal component analysis (PCA), three principal components (PC) were identified and accounted for 79.19% of the total variance. PC 1 (V, Cr, Mn, Ni, Cu, and Pb) is controlled by natural origins. PC 2 (As and Cd) is mainly contributed by anthropogenic origins in the basin. PC 3 (Zn) can be attributed to mixed sources of natural and anthropogenic origins. Moreover, all the partition coefficients (lgKd) exceeded 2.9 (arithmetical mean value order: Mn > Pb > Cd > V ≈ Cu > Cr ≈ Ni), indicating the powerful adsorptive ability of SPM for these heavy metal(loid)s during water/particle interaction.
Comparative Associations of Street Network Design, Streetscape Attributes and Land-Use Characteristics on Pedestrian Flows in Peripheral Neighbourhoods
Authors: Ozbil Ayse , Gurleyen Tugce , Yesiltepe Demet , Zunbuloglu Ezgi
Published: May 2019

Research has sufficiently documented the built environment correlates of walking. However, evidence is limited in investigating the comparative associations of micro- (streetscape features) and macro-level (street network design and land-use) environmental measures with pedestrian movement. This study explores the relative association of street-level design-local qualities of street environment-, street network configuration –spatial structure of the urban grid- and land-use patterns with the distribution of pedestrian flows in peripheral neighbourhoods. Street design attributes and ground-floor land-uses are obtained through field surveys while street network configuration is evaluated through space syntax measures. The statistical models indicate that the overall spatial configuration of street network proves to be a stronger correlate of walking than local street-level attributes while only average sidewalk width appears to be a significant correlate of walking among the streetscape measures. However, the most significant and consistent correlate of the distribution of flows is the number of recreational uses at the segment-level. This study contributes to the literature by offering insights into the comparative roles of urban design qualities of the street environment and street network layout on pedestrian movement. The findings also offer evidence-based strategies to inform specific urban design and urban master planning decisions (i.e., the provision of more generous sidewalks on streets with relatively higher directional accessibility) in creating lively, walkable environments.
A Review on the Use of Anti-TNF in Children and Adolescents with Inflammatory Bowel Disease
Authors: Aardoom Martine A. , Veereman Gigi , de Ridder Lissy
Published: May 2019

Inflammatory bowel disease (IBD) presents with disabling symptoms and may lead to insufficient growth and late pubertal development in cases of disease onset during childhood or adolescence. During the last decade, the role of anti-tumor necrosis factor (TNF) in the treatment of paediatric-onset IBD has gained more ground. The number of biologicals presently available for children and adolescents with IBD has increased, biosimilars have become available, and practices in adult gastroenterology with regards to anti-TNF have changed. The aim of this study is to review the current evidence on the indications, judicious use, effectiveness and safety of anti-TNF agents in paediatric IBD. A PubMed literature search was performed and included articles published after 2000 using the following terms: child or paediatric, Crohn, ulcerative colitis, inflammatory bowel disease, anti-TNF, TNF alpha inhibitor, infliximab, adalimumab, golimumab and biological. Anti-TNF agents, specifically infliximab and adalimumab, have proven to be effective in moderate and severe paediatric IBD. Therapeutic drug monitoring increases therapy effectiveness and safety. Clinical predictors for anti-TNF response are currently of limited value because of the variation in outcome definitions and follow-ups. Future research should comprise large cohorts and clinical trials comparing groups according to their risk profile in order to provide personalized therapeutic strategies.
Impact of the Subunit Arrangement on the Nonlinear Absorption Properties of Organometallic Complexes with Ruthenium(II) σ-Acetylide and Benzothiadiazole as Building Units §
Authors: Garoni Eleonora , Colombo Alessia , Kamada Kenji , Dragonetti Claudia , Roberto Dominique
Published: May 2019

In this paper, the nonlinear absorption properties of two complexes consisting of Ru(C≡CPh)(C≡C)(dppe)2 (dppe = Ph2PCH2CH2PPh2) as electron donor (D) and 4,7-di(2-thienyl)benzo[c][1,2,5]thiadiazole as electron acceptor (A) units in two different arrangement, i.e., A–D–A and D–A–D, are presented. They were measured in solution by the femtosecond open-aperture Z-scan method. The complexes show moderate two-photon absorption cross-sections σ(2) of several hundred to one thousand GM (here 1 GM = 10−50 cm4 s molecule−1 photon−1). Although they are formed by the same building units, it was found that the two-photon absorption values of the D–A–D arrangement are six times higher than that of the A–D–A one. This difference can be explained by the number of metal cores (one or two ruthenium centers), the geometrical configurations of the complexes (more or less planar), and the resonance enhancement by lowering the intermediate state.
Minimal Thermal Requirements for Development and Activity of Stored Product and Food Industry Pests (Acari, Coleoptera, Lepidoptera, Psocoptera, Diptera and Blattodea): A Review
Authors: Stejskal Vaclav , Vendl Tomas , Li Zhihong , Aulicky Radek
Published: May 2019

Low temperatures play an important role in arthropods because they affect both the individual and population development of all physiological and behavioural activities. Manipulation with low temperatures is a primary nonchemical pest control method. For stored product and food industry practitioners, a knowledge of pest thermal requirements, in particular threshold temperatures at which development and other activities of a particular pest species cease, is of crucial importance. This review presents summary data regarding the lower temperature thresholds of 121 species of stored product and food industry pests from six arthropod taxa (Acari, Coleoptera, Lepidoptera, Psocoptera, Diptera, and Blattodea). In particular, this review collected and summarized information regarding the lower development thresholds, lower population thresholds, lower acoustic or respiratory thresholds, lower walking and flying thresholds and lower trap capture thresholds for flying and walking arthropods. The average lower development threshold (LDT) differed among orders: the lowest was reported for Acari (6.8 °C) and Diptera (8.1 °C), followed by Lepidoptera (11.3 °C) and Psocoptera (13.8 °C), and the highest was reported for Coleoptera (14 °C) and Blattodea (15 °C). An exclusion-function was established showing the percentage of pest species (n = 112) that were developmentally suppressed (excluded) due to temperatures reaching the LDT in the range of decreasing temperatures from 25 °C to 0 °C. We scaled various temperature thresholds from the lowest to highest temperature as follows: the walking threshold, the trap capture threshold for walking insects, the lower development threshold, lower population threshold, lower flying threshold and the lower trap capture threshold for flying pests. Important pest species were identified for which information regarding the lower temperature threshold is missing, or for which the information is too variable and should be refined in future research.
Circulating miRNAs as Biomarkers for Endometriosis and Endometriosis-Related Ovarian Cancer—An Overview
Authors: Moga Marius Alexandru , Bălan Andreea , Dimienescu Oana Gabriela , Burtea Victoria , Dragomir Roxana Maria , Anastasiu Costin Vlad
Published: May 2019

Early detection and accurate diagnosis are pivotal in the management of endometriosis and endometriosis-related ovarian neoplasms (ERONs), yet there is no clear common ground regarding their pathogenesis. Endometriosis is a debilitating pathology that profoundly impairs the quality of life. Although the spontaneous resolution of endometriosis is possible, studies suggest that it can be a progressive condition, and ERONs can develop. The gold standard for diagnosis remains as the invasive method of laparoscopy followed by histological confirmation. In recent years, novel biomarkers have been discovered. MicroRNAs (miRNA) represent important epigenetic modulators of gene expression and are very attractive as biomarkers due to their lower complexity, tissue specificity, and stability in bodily fluids. Several studies have advanced the possibility of miRNAs becoming potential biomarkers in endometriosis and ERONs. Our aim is to bring these studies together in order to have a better understanding of whether, how, and when miRNAs might be used as biomarkers for these pathologies. Methods: We selected the reviewed papers from Google Academic, PubMed, and CrossRef. A total of eight studies met the inclusion criteria. Results: MiR-200 family, miR-143, 145, miR-20a, and miR199a were the most commonly dysregulated miRNAs in endometriosis, and miR-200 family was found to be dysregulated in both ERONs and endometriosis. Conclusions: No single miRNA was considered as a sole biomarker for this pathology. However, since the prognostic value of biomarkers is generally enhanced if more are assessed at the same time, a panel of miRNAs could be a better indicator of the disease.
The Clinical Significance of Programmed Death-1, Regulatory T Cells and Myeloid Derived Suppressor Cells in Patients with Nontuberculous Mycobacteria-Lung Disease
Authors: Shu Chin-Chung , Pan Sheng-Wei , Feng Jia-Yih , Wang Jann-Yuan , Chan Yu-Jiun , Yu Chong-Jen , Su Wei-Juin
Published: May 2019

Background: Increasing expression of programmed death-1 (PD-1) in patients with nontuberculous mycobacteria lung disease (NTM-LD) has been reported, but its role in clinical characteristics and outcomes remains unclear. Methods: We enrolled 96 participants, including 46 with Mycobacterium avium complex (MAC)-LD, 23 with M. abscessus (MAB)-LD, and 27 controls. We measured expressions of PD-1, cytotoxic T-lymphocyte antigen-4 (CTLA-4) and regulatory T (Treg) cells on CD4+ lymphocytes and myeloid-derived suppressor cells (MDSCs) and analyzed their association with clinical features and radiographic outcomes. Results: The percentage of PD-1 on CD4+(PD-1+CD4+) lymphocytes and MDSCs were higher in the MAC-LD group than the controls. There were no intergroup differences regarding CTLA-4+CD4+ lymphocytes. Higher PD-1+CD4+ lymphocytes were found in M. intracellulare- and M. avium-LD than in other MAC-LD. Positive sputum acid-fast stains and fibrocavitary radiographic lesions were correlated with elevated PD-1+CD4+ lymphocytes and Treg cells. The percentage of PD-1+CD4+ lymphocytes at the initial and 2 months of follow-up significantly predicted subsequent radiographic progression. Conclusion: As markers of immune tolerance, PD-1+CD4+ lymphocytes and MDSCs were higher in MAC-LD patients. The levels of PD-1+CD4+ and Treg cells were correlated with high mycobacteria bacilli burden in NTM-LD. Monitoring the expressions of PD-1+CD4+ lymphocytes may predict radiographic progression.
Magnetic Resonance Elastography of Liver in Light Chain Amyloidosis
Authors: Venkatesh Sudhakar K. , Hoodeshenas Safa , Venkatesh Sandeep H. , Dispenzieri Angela , Gertz Morie A. , Torbenson Michael S. , Ehman Richard L.
Published: May 2019

In this paper, we present our preliminary findings regarding magnetic resonance elastography (MRE) on the livers of 10 patients with systemic amyloidosis. Mean liver stiffness measurements (LSM) and spleen stiffness measurements (SSM) were obtained. Magnetic resonance imaging (MRI) images were analyzed for the distribution pattern of amyloid deposition. Pearson correlation analysis was performed in order to study the correlation between LSM, SSM, liver span, liver volume, spleen span, spleen volume, serum alkaline phosphatase (ALP), N-terminal pro b-type natriuretic peptide (NT pro BNP), and the kappa and lambda free light chains. An increase in mean LSM was seen in all patients. Pearson correlation analysis showed a statistically significant correlation between LSM and liver volume (r = 0.78, p = 0.007) and kappa chain level (r = 0.65, p = 0.04). Interestingly, LSM did not correlate significantly with SSM (r = 0.45, p = 0.18), liver span (r = 0.57, p = 0.08), or serum ALP (r = 0.60, p = 0.07). However, LSM correlated significantly with serum ALP when corrected for liver volume (partial correlation, r = 0.71, p = 0.03) and NT pro BNP levels (partial correlation, r = 0.68, p = 0.04). MRI review revealed that amyloid deposition in the liver can be diffuse, lobar, or focal. MRE is useful for the evaluation of hepatic amyloidosis and shows increased stiffness in hepatic amyloidosis. MRE has the potential to be a non-invasive quantitative imaging marker for hepatic amyloidosis.
Expression of Immune System-Related Membrane Receptors CD40, RANK, BAFFR and LTβR is Associated with Clinical Outcome of Operated Non-Small-Cell Lung Cancer Patients
Authors: Dimitrakopoulos Foteinos-Ioannis D. , Kottorou Anastasia E. , Antonacopoulou Anna G. , Panagopoulos Nikolaos , Scopa Chrisoula , Kalofonou Melpomeni , Dougenis Dimitrios , Koutras Angelos , Makatsoris Thomas , Tzelepi Vassiliki , Kalofonos Haralabos P.
Published: May 2019

An increasing number of studies implicates the NF-κB (Nuclear Factor of kappa light chain gene enhancer in B cells) alternative pathway in non-small-cell lung cancer (NSCLC). We assessed the clinical significance of CD40 (Tumor necrosis factor receptor superfamily member 5, TNFRSF5), BAFFR (B-cell activating factor receptor), RANK (Receptor activator of NF-κB) and LTβR (lymphotoxin β receptor) receptors, which activate the alternative pathway of NF-κB, in NSCLC. Evaluation of CD40, BAFFR, RANK and LTβR expression was performed based on the Cancer Genome Atlas (TCGA) and the Genotype-Tissue Expression (GTEx) datasets, while protein expression was assessed by immunohistochemistry in specimens from 119 operated NSCLC patients. CD40 gene overexpression was correlated with improved five-year overall survival (OS) (p < 0.001), while increased BAFFR and LTβR mRNA levels were associated with worse OS in patients with adenocarcinomas (p < 0.001 and p < 0.001, respectively). Similarly, patients with adenocarcinomas exhibited a negative correlation between membranous BAFFR protein expression in carcinoma cells and three- and five-year survival (p = 0.021; HR, 4.977 and p = 0.030; HR, 3.358, respectively) as well as between BAFFR protein overexpression in cancer-associated fibroblasts (CAFs) and two-year survival (p = 0.036; HR, 1.983). Patients with increased LTβR nuclear protein staining or stage II patients with lower cytoplasmic LTβR protein expression had worse five-year OS (p = 0.039 and p = 0.008, respectively). Moreover, CD40 protein expression in tumor infiltrating lymphocytes (TILs) and CAFs was positively associated with metastatic spread while BAFFR protein expression in CAFs was negatively associated with bone metastasis (p = 0.041). Our data suggests that CD40, BAFFR, RANK and LTβR play an important role in NSCLC and further supports the role of NF-κB alternative pathway in NSCLC.
Expression of PD-1 and CTLA-4 Are Negative Prognostic Markers in Renal Cell Carcinoma
Authors: Kahlmeyer Andreas , Stöhr Christine , Hartmann Arndt , Goebell Peter , Wullich Bernd , Wach Sven , Taubert Helge , Erlmeier Franziska
Published: May 2019

Immuno-oncological therapy with checkpoint inhibition (CI) has become a new standard treatment in metastatic renal cell carcinoma (RCC), but the prognostic value of the expression of CI therapy target molecules is still controversial. 342 unselected consecutive RCC tumor samples were analyzed regarding their PD-1, PD-L1, and CTLA-4 expression by immunohistochemistry (IHC). The prognostic values for cancer-specific survival (CSS) and overall survival (OS) were analyzed for those not exposed to CI therapy. The expression of PD-1 in tumor-infiltrating mononuclear cells (TIMC) and PD-L1 in tumor cells was detected in 9.4% and 12.3%, respectively (Immune reactive score (IRS) > 0). Furthermore, PD-L1 expression in TIMC (IRS > 0) and CTLA-4 expression in TIMC (>1% positive cells) was detected in 4.8% and 6.3%. PD-1 expression and CTLA-4 expression were significantly associated with a worse OS and CSS in log rank survival analysis and univariate Cox regression analysis. CTLA-4 expression is a prognostic marker that is independently associated with a worse outcome in multivariate Cox regression analysis in the whole cohort (OS: p = 0.013; CSS: p = 0.048) as well as in a non-metastatic subgroup analysis (OS: p = 0.028; CSS: p = 0.022). Patients with combined CTLA-4 expression and PD-1-expression are at highest risk in OS and CSS. In RCC patients, PD-1 expression in TIMC and CTLA-4 expression in TIMC are associated with a worse OS and CSS. The combination of PD-1 expression in TIMC and CTLA-4 expression in TIMC might identify high risk patients. This is, to our knowledge, the first description of CTLA-4 expression to be a prognostic marker in RCC.
Measurements of Night Sky Brightness in the Veneto Region of Italy: Sky Quality Meter Network Results and Differential Photometry by Digital Single Lens Reflex
Authors: Bertolo Andrea , Binotto Renata , Ortolani Sergio , Sapienza Simone
Published: May 2019

In this paper, we present the implementation of a monitoring network for artificial light at night (ALAN), based on Sky Quality Meter devices (SQM) installed in seven locations of the Veneto region. The system is coordinated by the Regional Environmental Protection Agency (ARPA-Veneto) and the Department of Physics and Astronomy of the University of Padova, in collaboration with a local dark-sky association, Venetostellato. A new centralized database containing zenith night sky brightness (NSB) data was implemented to collect data from all SQM stations of the regional territory, not only in real time (since 2017), but in some stations since 2011. We now have a dataset to determine how light pollution is affecting astronomical observatories. A WEB portal was created to offer different downloads from these NSB data. We present the results of some elaborations for the 2018 dataset (statistics, histograms, annual and cumulative plots) for seven monitoring sites. For Ekar and Pennar sites, we also present the NSB monthly trend from 2014 until the time of the study. We purchased a reflex camera with a fish eye lens, appropriately calibrated with the software (SW) Sky Quality Camera, which allowed us to study ALAN using differential photometry. Here, we present our first results obtained by studying the night evolution of light pollution in the urban location of Padova.
Hybrid TOA/RSS Range-Based Localization with Self-Calibration in Asynchronous Wireless Networks
Authors: Coluccia Angelo , Fascista Alessio
Published: May 2019

The paper addresses the problem of localization based on hybrid received signal strength (RSS) and time of arrival (TOA) measurements, in the presence of synchronization errors among all the nodes in a wireless network, and assuming all parameters are unknown. In most existing schemes, in fact, knowledge of the model parameters is postulated to reduce the high dimensionality of the cost functions involved in the position estimation process. However, such parameters depend on the operational wireless context, and change over time due to the presence of dynamic obstacles and other modification of the environment. Therefore, they should be adaptively estimated “on the field”, with a procedure that must be as simple as possible in order to suit multiple real-time re-calibrations, even in low-cost applications, without requiring human intervention. Unfortunately, the joint maximum likelihood (ML) position estimator for this problem does not admit a closed-form solution, and numerical optimization is practically unfeasible due to the large number of nuisance parameters. To circumvent such issues, a novel two-step algorithm with reduced complexity is proposed: A first calibration phase exploits nodes in known positions to estimate the unknown RSS and TOA model parameters; then, in a second localization step, an hybrid TOA/RSS range estimator is combined with an iterative least-squares procedure to finally estimate the unknown target position. The results show that the proposed hybrid TOA/RSS localization approach outperformed state-of-the-art competitors and, remarkably, achieved almost the same accuracy of the joint ML benchmark but with a significantly lower computational cost.
A System for Monitoring Breathing Activity Using an Ultrasonic Radar Detection with Low Power Consumption
Authors: Al-Naji Ali , Al-Askery Ali J. , Gharghan Sadik Kamel , Chahl Javaan
Published: May 2019

Continuous monitoring of breathing activity plays a major role in detecting and classifying a breathing abnormality. This work aims to facilitate detection of abnormal breathing syndromes, including tachypnea, bradypnea, central apnea, and irregular breathing by tracking of thorax movement resulting from respiratory rhythms based on ultrasonic radar detection. This paper proposes a non-contact, non-invasive, low cost, low power consumption, portable, and precise system for simultaneous monitoring of normal and abnormal breathing activity in real-time using an ultrasonic PING sensor and microcontroller PIC18F452. Moreover, the obtained abnormal breathing syndrome is reported to the concerned physician’s mobile telephone through a global system for mobile communication (GSM) modem to handle the case depending on the patient’s emergency condition. In addition, the power consumption of the proposed monitoring system is reduced via a duty cycle using an energy-efficient sleep/wake scheme. Experiments were conducted on 12 participants without any physical contact at different distances of 0.5, 1, 2, and 3 m and the breathing rates measured with the proposed system were then compared with those measured by a piezo respiratory belt transducer. The experimental results illustrate the feasibility of the proposed system to extract breathing rate and detect the related abnormal breathing syndromes with a high degree of agreement, strong correlation coefficient, and low error ratio. The results also showed that the total current consumption of the proposed monitoring system based on the sleep/wake scheme was 6.936 mA compared to 321.75 mA when the traditional operation was used instead. Consequently, this led to a 97.8% of power savings and extended the battery life time from 8 h to approximately 370 h. The proposed monitoring system could be used in both clinical and home settings.
Room-Temperature Creep Behavior and Activation Volume of Dislocation Nucleation in a LiTaO3 Single Crystal by Nanoindentation
Authors: Ma Yi , Huang Xianwei , Song Yuxuan , Hang Wei , Zhang Taihua
Published: May 2019

The crystal orientation effect on mechanical heterogeneity of LiTaO3 single crystals is well known, whilst the time-dependent plastic behavior, i.e., creep is still short of understanding. Relying on nanoindentation technology, we systematically studied room-temperature creep flows at various holding depths (100 nm to 1100 nm) in three typical orientations namely the X-112°, Y-36° and Y-42° planes. Creep resistance was much stronger in the X-112° plane than the others. In the meanwhile, creep features were similar in the Y-36° and Y-42° planes. The orientation effect on creep deformation was consistent with that on hardness. The nanoindentation length scale played an important role in creep deformation that creep strains were gradually decreased with the holding depth in all the planes. Based on strain rate sensitivity and yield stress, the activation volumes of dislocation nucleation were computed at various nanoindentation depths. The activation volumes ranged from 5 Å3 to 23 Å3 for the Y-36° and Y-42° planes, indicating that a point-like defect could be the source of plastic initiation. In the X-112° plane, the activation volume was between 6 Å3 and 83 Å3. Cooperative migration of several atoms could also be the mechanism of dislocation activation at deep nanoindentation.
The Phase Diagram and Exotic Magnetostrictive Behaviors in Spinel Oxide Co(Fe1−xAlx)2O4 System
Authors: Zhou Chao , Zhang Azhen , Chang Tieyan , Chen Yusheng , Zhang Yin , Tian Fanghua , Zuo Wenliang , Ren Yang , Song Xiaoping , Yang Sen
Published: May 2019

We report the magnetic and magnetostrictive behaviors of the pseudobinary ferrimagnetic spinel oxide system (1−x)CoFe2O4–xCoAl2O4 [Co(Fe1−xAlx)2O4], with one end-member being the ferrimagnetic CoFe2O4 and the other end-member being CoAl2O4 that is paramagnetic above 9.8 K. The temperature spectra of magnetization and magnetic susceptibility were employed to detect the magnetic transition temperatures and to determine the phase diagram of this system. Composition dependent and temperature dependent magnetostrictive behaviors reveal an exotic phase boundary that separates two ferrimagnetic states: At room temperature and under small magnetic fields (∼500 Oe), Fe-rich compositions exhibit negative magnetostriction while the Al-rich compositions exhibit positive magnetostriction though the values are small (<10 ppm). Moreover, the compositions around this phase boundary at room temperature (x = 0.35, 0.4, 0.45, 0.5) exhibit near-zero magnetostriction and enhanced magnetic susceptibility, which may be promising in the applications for magnetic cores, current sensors, or magnetic shielding materials.
Effect of Micro-Scale Er on the Microstructure and Fluidity of ZL205A Alloy
Authors: Guo Tingbiao , Wang Bing , Zhang Zhanfei , Sun Quanzhen , Jin Yuhua , Ding Wanwu
Published: May 2019

The effect of Er addition on the fluidity and microstructure transformation of the as-cast and T5 heat-treated ZL205A alloys was investigated by optical microscope (OM), scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy dispersive spectrometer (EDS). The fluidity of the liquid metal after adding Er was tested and the fracture characteristics of the material were analyzed. The results indicated that Er was mainly dissolved into an α–Al matrix near the grain boundaries (GBs). It is easily segregated and enriched in the intersection of the GBs or the interface between the α and θ phase, which caused the intermetallic compounds to be distributed along the GBs to the neck and to fuse. Er could also inhibit the diffusion of Cu atoms in the process of solid solution, so that increased the residual eutectic structures in the crystal, while accelerating the precipitation progress of the Guinier–Preston (GP) zone and θ’ phase and increasing precipitation of the θ phase. A small amount of precipitation of θ phase and micro-scale Er (0.1–0.5 wt %) can significantly increase the fluidity and reduce the casting defects, which can effectively improve the castability of the ZL205A alloy. The interface between the (Al8Cu4Er) phase and matrix is the main area of microcracks, through analyzing the fracture morphology.
The Durability of Concrete Modified by Waste Limestone Powder in the Chemically Aggressive Environment
Authors: Kępniak Maja , Woyciechowski Piotr , Łukowski Paweł , Kuziak Justyna , Kobyłka Rafał
Published: May 2019

The idea of sustainable development assumes that natural resources must be treated as limited goods and that waste must be managed rationally. This idea and the constant striving to reduce production costs make the use of waste materials as substitutes for traditionally used raw materials from non-renewable sources increasingly popular. In cement concrete technology, there are many possibilities to use waste as components of mortars and concretes. The subject of this paper is a fine-grained material, obtained as a by-product during the preparation of aggregate for mineral-asphalt mixtures. The aim of the research was to test the suitability of the selected type of powder, namely limestone powder, as a component of cement composites. The paper presents an evaluation of the potential of using the limestone powder as a substitute for the fine aggregate, focusing on the impact of such a modification on aspects of durability. The sulfate degradation and chloride ion diffusion in concrete were investigated. The overall desirability function has been determined. It was demonstrated that the satisfactory value of the general desirability can be attributed to most of the investigated concretes. Positive test results support the potential of replacing part of natural fine aggregate with the tested waste limestone dust without a negative impact on the durability of concrete.
Effects of Lignin-Based Hollow Nanoparticle Structure on the Loading and Release Behavior of Doxorubicin
Authors: Zhou Yu , Han Yanming , Li Gaiyun , Chu Fuxiang
Published: May 2019

Because of their exceptional absorption capacity, biodegradability, and nontoxicity, nanomaterials fabricated from renewable natural resources have recently become an increasingly important research area. However, the mechanism of drug encapsulation by lignin nanoparticles and the role of nanoparticle structure on the stability and loading performance still remain unknown. Herein, lignin hollow nanoparticles (LHNPs) were prepared and applied as promising vehicles for the antineoplastic antibiotic drug doxorubicin hydrochloride (DOX). The hydrogen bonding and π−π interactions contributed to the encapsulation of hydrophilic DOX by LHNPs with hydrophobic cavities. The encapsulation of DOX was enhanced by the pore volume and surface area. In addition, the nanoparticles contributed to the cellular uptake and the accumulation of the drug within HeLa cells. This work provides a scientific basis for future studies on the selective entrapment properties of hollow polymer nanoparticles derived from biomass material as vehicles for overcoming pharmacokinetic limitations.
Enhancement of Complex Permittivity and Attenuation Properties of Recycled Hematite (α-Fe2O3) Using Nanoparticles Prepared via Ball Milling Technique
Authors: Mensah Ebenezer Ekow , Abbas Zulkifly , Azis Raba’ah Syahidah , Khamis Ahmad Mamoun
Published: May 2019

The purpose of this study was to synthesize high-quality recycled α-Fe2O3 to improve its complex permittivity properties by reducing the particles to nanosize through high energy ball milling. Complex permittivity and permeability characterizations of the particles were performed using open-ended coaxial and rectangular waveguide techniques and a vector network analyzer. The attenuation characteristics of the particles were analyzed with finite element method (FEM) simulations of the transmission coefficients and electric field distributions using microstrip model geometry. All measurements and simulations were conducted in the 8–12 GHz range. The average nanoparticle sizes obtained after 8, 10 and 12 h of milling were 21.5, 18, and 16.2 nm, respectively, from an initial particle size of 1.73 µm. The real and imaginary parts of permittivity increased with reduced particle size and reached maximum values of 12.111 and 0.467 at 8 GHz, from initial values of 7.617 and 0.175, respectively, when the particle sizes were reduced from 1.73 µm to 16.2 nm. Complex permeability increased with reduced particle size while the enhanced absorption properties exhibited by the nanoparticles in the simulations confirmed their ability to attenuate microwaves in the X-band frequency range.
Hermite-Hadamard-Fejér Type Inequalities for Preinvex Functions Using Fractional Integrals
Authors: Mehmood Sikander , Zafar Fiza , Yasmin Nusrat
Published: May 2019

In this paper, we have established the Hermite–Hadamard–Fejér inequality for fractional integrals involving preinvex functions. The results presented here provide new extensions of those given in earlier works as the weighted estimates of the left and right hand side of the Hermite–Hadamard inequalities for fractional integrals involving preinvex functions doesn’t exist previously.
New Concepts of Picture Fuzzy Graphs with Application
Authors: Zuo Cen , Pal Anita , Dey Arindam
Published: May 2019

The picture fuzzy set is an efficient mathematical model to deal with uncertain real life problems, in which a intuitionistic fuzzy set may fail to reveal satisfactory results. Picture fuzzy set is an extension of the classical fuzzy set and intuitionistic fuzzy set. It can work very efficiently in uncertain scenarios which involve more answers to these type: yes, no, abstain and refusal. In this paper, we introduce the idea of the picture fuzzy graph based on the picture fuzzy relation. Some types of picture fuzzy graph such as a regular picture fuzzy graph, strong picture fuzzy graph, complete picture fuzzy graph, and complement picture fuzzy graph are introduced and some properties are also described. The idea of an isomorphic picture fuzzy graph is also introduced in this paper. We also define six operations such as Cartesian product, composition, join, direct product, lexicographic and strong product on picture fuzzy graph. Finally, we describe the utility of the picture fuzzy graph and its application in a social network.
Characterization of an Alkaline Alginate Lyase with pH-Stable and Thermo-Tolerance Property
Authors: Wang Yanan , Chen Xuehong , Bi Xiaolin , Ren Yining , Han Qi , Zhou Yu , Han Yantao , Yao Ruyong , Li Shangyong
Published: May 2019

Alginate oligosaccharides (AOS) show versatile bioactivities. Although various alginate lyases have been characterized, enzymes with special characteristics are still rare. In this study, a polysaccharide lyase family 7 (PL7) alginate lyase-encoding gene, aly08, was cloned from the marine bacterium Vibrio sp. SY01 and expressed in Escherichia coli. The purified alginate lyase Aly08, with a molecular weight of 35 kDa, showed a specific activity of 841 U/mg at its optimal pH (pH 8.35) and temperature (45 °C). Aly08 showed good pH-stability, as it remained more than 80% of its initial activity in a wide pH range (4.0–10.0). Aly08 was also a thermo-tolerant enzyme that recovered 70.8% of its initial activity following heat shock treatment for 5 min. This study also demonstrated that Aly08 is a polyG-preferred enzyme. Furthermore, Aly08 degraded alginates into disaccharides and trisaccharides in an endo-manner. Its thermo-tolerance and pH-stable properties make Aly08 a good candidate for further applications.
Group-1 Grass Pollen Allergens with Near-Identical Sequences Identified in Species of Subtropical Grasses Commonly Found in Southeast Asia
Authors: Aud-in Sirirat , Somkid Koravit , Songnuan Wisuwat
Published: May 2019

Background and objectives: Group-1 grass allergens or beta-expansins (EXPBs) are major allergens from pollen of all grass species. Previous studies showed that they are highly conserved (64–85%) in Pooideae species, which are found mostly in the temperate regions. However, the information about group-1 allergens from common grass species in subtropical areas is still lacking. This study aimed to assess the sequence diversity of group-1 grass pollen allergens in subtropical areas, especially in Southeast Asia. Materials and Methods: Group-1 allergens were cloned from pollen of eight grass species using a single set of primers. Sequences were analyzed and IgE and IgG4 binding regions were compared to the previously reported epitopes in homologous EXPBs. The phylogenetic analysis was used to assess the relationship between sequences of these species and previously characterized EXPBs. Moreover, three-dimensional structure of the EXPB was modeled based on homology to Zea m 1. Results: Sequences from eight grass species were nearly identical. It is conceivable that the primers used for cDNA amplification detected the same isoform in different species. In fact, the deduced amino acid sequences shared 97.79–100% identity with each other and 15/819 polymorphic nucleotide positions were identified. The predicted structure showed that the IgE and IgG4 epitopes and polymorphic residues were located in both domains 1 and 2. The dendrogram presents clustering of class A EXPBs into four groups corresponding to the grass subfamilies. Conclusions: This study identified the allergens with near-identical sequences from different grass species. This isoform could be the major cross-reacting allergenic protein from commonly found grass species.
The Effect of Oxidant Hypochlorous Acid on Platelet Aggregation and Dityrosine Concentration in Chronic Heart Failure Patients and Healthy Controls
Authors: Mongirdienė Aušra , Laukaitienė Jolanta , Skipskis Vilius , Kašauskas Artūras
Published: May 2019

Background and objective: One of the reasons for thrombosis in chronic heart failure (CHF) might be reactive forms of oxygen activating platelets. The aim of this study was to evaluate the effect of oxidant hypochlorous acid (HOCl) on platelet aggregation and dityrosine concentration in CHF patients and healthy controls. Materials and Methods: CHF patients (n = 67) and healthy (n = 31) were investigated. Heart echoscopy, 6-min walking test, complete blood count, platelet aggregation, and dityrosine concentration were performed. Platelet aggregation and dityrosine concentration were measured in plasma samples after incubation with different HOCl concentrations (0.15, 0.0778, and 0.0389 mmol/L). Results: Platelet aggregation without oxidant was lower (p = 0.049) in CHF patients than in controls. The spontaneous platelet aggregation with oxidant added was higher in CHF patients (p = 0.004). Dityrosine concentration was also higher (p = 0.032) in CHF patients. Platelet aggregation was the highest in samples with the highest oxidant concentration in both healthy controls (p = 0.0006) and in CHF patients (p = 0.036). Platelet aggregation was higher in NYHA III group in comparison to NYHA II group (p = 0.0014). Concentration of dityrosine was significantly higher in CHF samples (p = 0.032). The highest concentration of dityrosine was obtained in NYHA IV group samples (p < 0.05). Intensity of platelet aggregation, analyzed with ADP, was correlated with LV EF (r = 0.42, p = 0.007). Dityrosine concentration was correlated with NYHA functional class (r = 0.27, p < 0.05). Conclusions: The increase in platelet aggregation in CHF and healthy controls shows the oxidant effect on platelets. The increase in dityrosine concentration in higher NYHA functional classes shows a higher oxidative stress in patients with worse condition.
Longitudinal Extensive Transverse Myelitis in an Immunocompetent Older Individual—A Rare Complication of Varicella-Zoster Virus Reactivation
Authors: Abbas Samar A. , El Helou Jeanine , Chalah Moussa A. , Hilal Hanine , Saliba Gaby , Abboud Halim , Ayache Samar S.
Published: May 2019

Varicella-zoster virus (VZV) is a human neurotropic herpes virus that causes chickenpox in children. After becoming latent in dorsal root ganglia, it can reactivate to cause dermatological manifestations, the most common one being shingles or herpes zoster. Severe neurologic dysfunctions can occur in immunocompromised patients such as encephalitis, meningitis, myelitis and neuropathy. Longitudinal extensive transverse myelitis (LETM) is an unusual neurological complication mainly described in immunocompromised patients, with very few cases described in immunocompetent ones. We hereby report a case of VZV-induced LETM in an immunocompetent older adult—a situation rarely described in the literature. LETM is a rare complication of VZV and its pathogenesis; therapeutic interventions and prognosis are far from being fully clarified. However, a prompt diagnosis is needed to allow a rapid initialization of treatment and ensure a better outcome. Although the therapeutic lines are not clear, immunosuppressive agents may have their place in cases of unsuccessful results and/or relapses following acyclovir coupled with a well conducted methylprednisolone therapy. Further studies are highly needed to improve the current understanding of the disease course and mechanisms, and to optimize therapeutic strategies.