bluuebunny/crossref_metadata_2025 huggingface dataset:
Identifying parameters for wood protection against water absorption
Authors: Tsapko Yuriy , Likhnyovskyi Ruslan , Horbachova Oleksandra , Mazurchuk Serhii , Tsapko Аleksii , Sokolenko Kostiantyn , Matviichuk Andrii , Sukhanevych Maryna
Published: January 2023

An issue related to using wood and timber for building structures is to ensure the stability and durability during operation within wide limits. Therefore, the object of research was the inhibition of the process of water absorption of pine and hornbeam wood during a thermal change in its structure. It is proved that in the process of thermal modification of wood, its structure changes, and, accordingly, water absorption. Namely, the maximum increase in mass under the action of water on an untreated sample of wood was more than 40 %, after thermal modification – less than 35 %. The increase in the mass of wood samples thermally modified and treated with a hydrophobic agent was less than 25 %. On the basis of the obtained results of physicochemical studies, discrepancies were found in the IR spectra of wood, both during thermal modification and with additional treatment with a hydrophobic agent, indicating structural changes in the components. In particular, the decrease or absence of the intensities of the absorption bands of some functional groups and the appearance or intensification of others. On the original hornbeam and pine thermogram, thermally modified, and thermally modified with the addition of a hydrophobic coating, thermogravimetric curves are similar to each other and are characterized by a loss of sample mass. This is possible with increasing temperature due to the processes of dehydration, destruction of hemicellulose, lignin, and cellulose with the formation of a non-combustible residue. During heat treatment of cellulose in the region of temperatures of 150÷450 °C, two processes take place in parallel. This is dehydration, accompanied by the destruction of the pyranose cycle and carbonization to form a carbon residue. Also, the process of destruction of glycosidic bonds while maintaining hydroxyl groups, accompanied by regrouping of pyranose cycles.
Devising ways to improve the financial and tax mechanisms for overcoming the socio-economic crisis caused by martial law
Authors: Dmytryk Olga , Sereda Olena , Tokarieva Katerina , Damirchyiev Mushfik , Zinovatna Iliana
Published: January 2023

The object of this study is the process of improving financial and tax mechanisms to overcome the socio-economic crisis caused by martial law in Ukraine in the context of digital transformation. During the study, the problem of non-compliance of the existing financial and tax mechanisms with the requirements of digital transformation and the peculiarities of the functioning of the financial sphere under martial law was solved. The key elements of financial and tax mechanisms that should be primarily revised in order to overcome the socio-economic crisis have been clarified. The shortcomings of the functioning of financial and tax mechanisms for overcoming the socio-economic crisis are highlighted. The results of a survey of experts on the proposed factors influencing the effectiveness of such mechanisms were analyzed using the Kendall's concordance coefficient. The most significant factors that formed the basis for the developed directions for improving the financial and tax mechanisms for overcoming the socio-economic crisis have been established. The peculiarities and distinctive features of the results obtained are unanimous consideration of the requirements of digital transformation and the peculiarities of the functioning of the financial sphere under martial law. The financial and tax mechanisms improved on the basis of digital technology are based on the declared principles of G20 digital financial inclusion. The most significant factors of influence were the infrastructure of financial and tax mechanisms; legal and regulatory framework for digitalization; combating digital fraud; adaptation of foreign experience in the use of digital technologies to the national environment. The results can be used in the practical activities of the financial authorities of Ukraine in order to overcome the socio-economic crisis under martial law
Revealing the features of the third order phase spectrum of the main dangerous parameters of the gas medium
Authors: Pospelov Boris , Bezuhla Yuliia , Yashchenko Oleksandr , Khalmuradov Batyr , Petukhova Olena , Gornostal Stella , Kozar Yurii , Tishechkina Kateryna , Salamatina Olga , Ihnatenko Zhanna
Published: January 2023

The object of this study is the dynamics of hazardous parameters of the gas environment when materials are ignited in the premises. The task addressed was the early detection of fires in the premises. It is proposed to resolve this issue on the basis of using an assessment of the coherence of frequency components in the third-order spectrum relative to the dynamics of hazardous parameters of the gas environment. The results indicate the nonlinear nature of the dynamics of hazardous parameters of the gas environment both in the absence and in the presence of fires. It was established that the assessment of the coherence of the frequency components relative to the considered triplets in the third-order spectrum contains information on the ratio of order to chaos in the dynamics of hazardous parameters of the gas environment. This information can be used to reliably detect fires. It was found that when the test materials in the form of alcohol, paper, wood, and textiles are ignited, the ratio of order to chaos in the temperature and CO dynamics in a gaseous medium is halved. It was established that the average values for frequency indices from 0 to 20 of the coherence of the frequency components of the dynamics of hazardous parameters on the ignition interval of test materials are in the range from +0.005 to –0.187. At the same time, in the interval of absence of ignition of test materials, the average values of the coherence assessment for frequency indices from 0 to 20 are in the range from +0.48 to +0.022. The reported results generally indicate the prospects and further development of studies into the coherence of the frequency components of the third-order spectrum for the dynamics of hazardous parameters of the gas environment in order to detect fires in the premises
Formation of regulatory means to fix technology efficiency criteria for its further financing and budget support. The experience of Ukraine and prospects for improvement under the conditions of martial law
Authors: Davydiuk Oleksandr , Ostapenko Iuliia , Tovkun Liudmyla , Sharenko Maxim , Shulga Tetyana
Published: January 2023

Some study revealed the absence of a generally accepted approach to determining the requirements for the efficiency and effectiveness of technology as an object of civil and economic relations. The need to form recommendations on the content of legal norms and contractual clauses that can be used to fix them in the specified means of regulation is substantiated. It is proved that provided that the current legislation of a particular country fixes universal criteria for determining the effectiveness of technology, this will have a positive impact on their transfer. Thus, on the one hand, all participants in the relationship of technology circulation will receive indicators and an understanding of how to separate an effective technology from pseudo- and outdated technologies. On the other hand, public officials will have a guideline on what technologies cannot be provided with budget funding and support. And the parties to the contractual relationship will be able to fix in the relevant agreements more effective protective clauses, which will help protect their legitimate interests and stabilize investment risks.
Existing approaches to determining the degree of efficiency of technologies were defined and systematized. The analysis of the feasibility and possibility of using macroeconomic and local performance indicators was carried out. General circumstances have been formed that affect the formation of the category of technology efficiency. These include the territory and level of technological development of the implementation area. The suitability and adaptability of the technology to the ability to perform the tasks assigned to it and others.
As a result of the study, universal designs for identifying the effectiveness of the technology were proposed. They are proposed for use in the formation of national and international legislation and protective contractual clauses
Development of an untraditional technique to control the structure of the output flow from a vortex chamber
Authors: Turyk Volodymyr , Kochin Viktor , Moroz Volodymyr , Miliukov Dmytro
Published: January 2023

A technique of using coherent vortex formations of the dead-end zone of the vortex chamber of the end type as a controlling factor influencing the structure and characteristics of the output flow has been developed. The kinematic parameters of the flow relative to chambers with elongated and extremely short dead-end parts in the range of Reynolds numbers according to the parameters of the nozzle Re=47080–86530 were investigated. The reaction of the flow structure in the output sections of the vortex chambers was determined experimentally using thermoanemometry. Profiles of time-averaged transversal and axial velocity projections, as well as corresponding values of the relative intensity of velocity pulsations, were obtained. It was found that at Re=86530, the elongation of the dead-end part of the chamber leads to a decrease in the initial cross-section of the transversal component by 15 % with an increase in the axial component by 19.7 %, and, at Re=47080, to a decrease in the transversal component by 21 % with an increase in the axial component by 8.5 %. This indicates the redistribution of kinetic energy from transversal to axial energy motion, which is confirmed by the analysis of the corresponding intensity profiles of the velocity pulsations in the output section of the chamber in the near-wall and near-axis zones of the flow. The integral intensity of the velocity pulsations along the initial cross-section of comparable chamber designs increases in a chamber with an elongated dead-end part with almost no additional energy losses. The obtained results form the basis of a rational method of controlling the macro- and microstructure of flows, which determines the efficiency of mass exchange and heat exchange processes in vortex chambers of the end type. Such designs are characteristic of vortex mixers, burners of industrial furnaces, furnace devices of hot water and steam boilers, and other technological and power equipment
Assessment of the stressed-strained state of a reinforced transport pipe under the combined effect of ambient temperature and static loads
Authors: Kovalchuk Vitalii , Rybak Roman , Hnativ Yuriy , Tkachenko Valentyna , Onyshchenko Artur , Kravets Ivan , Hermaniuk Yuliia , Babyak Mykola , Hembara Nataliya , Velhan Ihor
Published: January 2023

The object of this study is a reinforced three-layer transport pipe, which is subjected to the joint action of ambient temperature and static loading of the road subgrade soil.
The analytical model for assessing the stressed-strained state of reinforced three-layer pipes, under the combined action of temperature and static loads, has been improved using the theory of elasticity.
The stressed-strained state of the reinforced pipe was assessed taking into account the values of the joint action of temperature and loads from vehicles, the physical and mechanical parameters of structural materials, and the geometric parameters of the pipe.
As a result of the calculation of the reinforced multilayer pipe, it was found that the maximum movements that occur on the outside of the defective pipe are 0.64 mm, the metal pipe – 0.75 mm, and in the concrete mortar (fine-grained concrete) – 0.69 mm.
It was established that under the combined action of ambient temperature and static loads from the road subgrade soil, ring stresses are maximum. They are 151 MPa. Axial stresses are also high – 141 MPa. At the same time, the maximum radial stresses are the smallest – 37.4 MPa.
It has been established that a small difference in displacements occurs on the contact of structural materials of the reinforced pipe. However, the magnitude of the stresses is high. The maximum difference in ring stresses was 73 MPa, while the difference in radial and axial stresses was up to 1.0 MPa.
It has been established that to restore the bearing capacity of damaged reinforced concrete pipes, it is possible to use the repair technology by the method of "sleeving". It involves pulling a metal pipe into the middle of the layer damaged with concrete mortar remaining between the concrete defective and the new metal pipes.
Determining the medical and biological safety of meat-containing polycomponent products based on regional raw materials
Authors: Pasichnyi Vasyl , Tischenko Vasyl , Bozhko Nataliia , Marynin Andrii , Moskaluyk Oksana , Geredchuk Alina
Published: January 2023

This paper reports medical and biological studies of semi­finished meat product and meat­containing semi­smoked sausage on laboratory rats. The purpose of the study was to investigate the effect of the developed products on the dynamics of live weight, the state of internal organs and tissues, general and biochemical parameters of the blood of animals when they are introduced into the standard diet in the amount of 30 %. The studies were conducted on 30 white nonlinear rats weighing 145–150 g, of which one control and two experimental groups were formed, according to the principle of the method of analog groups.It is proved that the introduction of meat­containing multicomponent products with a high protein content into the diet of rats in the amount of 30 % of the standard diet contributes to the intensification of animal growth processes. It was confirmed that the increase in live body weight of rats after 21 days of the experiment amounted to 33–38 %, which is larger than that in control by 69–90 %. No negative impact on the state of the internal organs of rats from the consumption of the developed products was detected.It was found that the inclusion of meat­containing multicomponent products in the diet of rats contributes to an increase in erythropoiesis by 12.66 % compared to the starting data. The inclusion of products in the diet does not significantly change the content of leukocytes and platelets while increasing blood saturation with hemoglobin by 45.83–58.33 % higher compared to control animals.The introduction into the diet of laboratory rats of meat­containing multicomponent products has an anabolic effect and contributes to an increase in the concentration of hemoglobin by 42.12 %, total protein by 4.79 %, creatinine by 19.68 %. In laboratory rats, there is a decrease in glucose by an average of 8.17 %, which indicates an intensification of processes in muscle tissue. Enhanced protein synthesis due to increased catabolism leads to an increase in bilirubin concentration by 19.12–21.97 % compared to control rats. Medical and biological studies of meat­containing multicomponent products can be applied in practice to confirm their safety
Automatic construction of a fuzzy system with a matrix representation of rules and a correct knowledge base
Authors: Yehoshkin Danylo , Guk Natalia
Published: January 2023

The object of this study is the process of automatic formation of fuzzy production rules on the basis of a training sample for solving the classification problem. The problem of automatically creating and then checking the correctness of a fuzzy inference model for a classification task is solved. The result is an automatically constructed correct database of rules for solving the classification problem. Analysis of the correctness of the knowledge base is carried out using the criteria of completeness, minimality, coherence, and consistency. To prove the completeness of the rule base, Hoare logic and the resolution method are used. The quality of the classification is assessed using such metrics as accuracy, precision, recall, f1-score. The dependence of the classification result on the size of the training sample is considered.
The expert system has the following features: the ability to learn from data; high level of accuracy; the correct knowledge base. The knowledge base is formed using the objects of the training sample on the basis of linguistic variables and term sets. A production model of knowledge representation is applied, combining the Mamdani and Takagi-Sugeno-Kang models. It is assumed that the left parts of the production rules describe combinations of the features of objects, and the right parts correspond to classes. The matrix representation of the antecedents of the rules is used. Consequents are represented as a column vector. For the automatic construction of the matrix of antecedents, it is proposed to use the Cartesian product. The formation of the consequent vector is carried out automatically using domain data and a training procedure.
The resulting expert system can be used to solve the problems of classification, clustering, data mining, and big data analysis
Devising a procedure for defining the general criteria of abnormal behavior of a computer system based on the improved criterion of uniformity of input data samples
Authors: Semenov Serhii , Mozhaiev Oleksandr , Kuchuk Nina , Mozhaiev Mykhailo , Tiulieniev Serhii , Gnusov Yurii , Yevstrat Dmytro , Chyrva Yuliia , Kuchuk Heorhii
Published: January 2023

The object of this study was the process of detecting anomalies in computer systems. The task to timely detect anomalies in computer systems was solved, based on a mathematical model underlying which is the criteria for uniformity of samples of input data. The necessity and possibility to devise a universal and at the same time scientifically based approach to tracking the states of the system were determined. Therefore, the purpose of this work was to develop a methodology for determining the general criterion of anomaly in the behavior of a computer system depending on the input data. This will increase the reliability of identifying the anomaly in the behavior of the system, which, in turn, should increase its safety. To solve the problem, a mathematical model for detecting anomalies in the behavior of a computer system has been built. The mathematical model differs from the well-known ones in the possibility of isolating a series of observations, the results of which show the anomaly in the behavior of the computer system. This made it possible to ensure the necessary level of reliability of the results of monitoring and research. In the process of modeling, the criteria for uniformity of samples of input data have been investigated and improved. The expediency of using the improved criterion of uniformity of samples of input data in the case of a significantly unequal distribution of values from the sensors of computer systems has been proved. An algorithm for the functioning of the software test tool has been developed. The results of the study showed that the confidence probability that the value of the statistical values of the shift in a certain criterion does not deviate from the mathematical expectation by more than 0.05 is approximately equal to 0.94. The scope of the obtained results is systems for detecting anomalies of computer systems. A necessary condition for the use of the proposed results is the presence of a series of observations of the state of the computer system
Theoretical substantiation of the conditions for capture of fiber by the working drum by the knife in roller gins
Authors: Veliev Fazil
Published: January 2023

Roller ginning provides 2–3 times less mechanical damage to cotton fiber than saw ginning. In recent years, these positive moments have predetermined attempts to gin medium-fiber cotton on roller gins. However, the low productivity of roller gins compared to saw gins does not yet allow for a complete transition to this process.
To design high-efficiency roller gins, it is necessary to deeply study the mechanics of the basic processes of interaction of raw cotton with the working organs of the gin. It is necessary to determine the reserves for improving the efficiency of the process of capturing and tightening the fiber behind the knife, to investigate the mechanics of the process of rebounding seeds, and to find new solutions to reduce their damage.
As a result of the research reported here, a mathematical model of the roller ginning process has been built, which makes it possible to determine the impact of technological and structural parameters of the roller gin on the efficiency of the process. This allows for the reasonable application of a variable periodic friction field between the knife and working drum.
When studying the kinematics of the interaction of the surface of the working drum with the knife, dependences were established to accelerate the points of the surface of the working drum before it enters behind the knife, making it possible to determine the forces acting on the fiber when it is captured by the micro-irregularities of the drum.
In the study of the process of tightening the fiber with a pair of working drum-fixed knife, the conditions for ginning the flyer fibers and the dependence of productivity on the average pressure in the contact of the knife with the drum were determined. The study of the influence of the rigid characteristics of the working drum-knife system on the ginning capacity of a roller gin has made it possible to reveal new reserves for improving the efficiency of roller ginning
Analysis of the effect of employee status on construction worker's safety behavior using structural equation model
Authors: Damayanti Fifi , Djakfar Ludfi , Wisnumurti Wisnumurti , Nugroho Agung Murti
Published: January 2023

The construction industry is one of the most at risk to worker safety. The number of work accidents in Indonesia continues to increase so that by 2021 the number of work accidents will reach 234,270 cases. Therefore, in-depth research is needed to maintain the safety of all workers. Recognizing the factors that cause work accidents helps stakeholders take preventive action. It is necessary to increase worker safety behaviour by identifying its factors. Both those that occur in casual workers and permanent workers. Therefore, it is important to see whether employment status affects the safety behaviour of construction workers so that preventive measures can be taken as a form of prevention of work accidents. The research objective was to analyze the status of workers on the safety behaviour of construction workers. Data was collected through a survey method of 300 construction workers in the cities of Surabaya, Malang, and Batu in East Java, Indonesia. The results of the study show that worker status has a positive effect on construction work safety behaviour. This means that the higher the Employee Status will increase the Safety Behavior variable, with a path coefficient of 0.390. Among the indicators that are dominant in measuring the ES Worker Status construct is the Type of Worker, with the highest loading factor of 0.842. Thus, if the management wants to raise the value of the variable Safety Behavior through improving aspects of Employee Status, what need to be evaluated as a top priority is the Employee Type. The results of this study can be used as a reference in setting policies related to worker safety. Project management can determine what strategic steps need to be taken for construction workers with different types of employee statuses. so as to increase worker awareness of a culture of safety behavior.
Improvement of Turkish delight production technology using a developed multi-component fruit and vegetable paste
Authors: Kasabova Kateryna , Samokhvalova Olga , Zagorulko Aleksey , Zahorulko Andrii , Babaiev Serhii , Bereza Olena , Ponomarenko Nataliia , Tesliuk Hennadii , Yukhno Viktor
Published: January 2023

The object of this study is the technology of Turkish delight production based on fruit and vegetable paste with a high content of physiologically functional ingredients. The chemical composition of Turkish delight has been optimized by introducing physiologically functional ingredients. As a source of physiologically functional ingredients, it was proposed to use a multicomponent fruit and vegetable paste from apples, quince, pumpkins, made in an improved way. The technique is characterized by concentrating the paste in the rotary evaporator for 30...42 s at a temperature of 60...63 °C under conditions of preheating the purée to 50...52 °C. The dependence of the effective viscosity on the shear rate of samples of fruit and vegetable pastes was determined and it was found that the best indicators characterized the paste with a formulation ratio of raw materials: apple – 30 %; quince – 50 %; pumpkin – 20 %. The resulting paste has good organoleptic properties and a high content of dietary fiber, ascorbic acid, polyphenolic compounds.
It has been established that the production of Turkish delight with the addition of the developed fruit and vegetable paste provides the product with good organoleptic characteristics. Namely, it is characterized by a sweet-sour taste with a pleasant smell of quince, rich yellow-orange color, gelatinous, slightly viscous consistency, and the proper shape with a clear contour. Also, the addition of fruit and vegetable paste reduces the formulation amount of starch by 20 % while the resulting Turkish delight is characterized by a high strength value τ=38 kPa.
The improved technology of Turkish delight could expand the range of "healthy products" with increased nutritional value. In addition, the proposed technique and the modes of concentration make it possible to organize the process of paste production using energy-saving equipment.
Revealing the influence of structural and operational parameters of a wooden hydrostatic bearing on its performance
Authors: Nazin Vladimir
Published: January 2023

Wooden bearings, lubricated with water and other low-viscosity lubricants, have been used for centuries. In steamship engines, turbines of hydroelectric power plants and propellers of submarines, it is proposed to use wooden hydrostatic bearings, which are guaranteed to provide liquid friction and have high reliability.
The object of this study is hydrostatic and thermal processes in sliding supports with wooden hydrostatic bearings. The influence of the design and operational parameters of a wooden hydrostatic bearing on its performance was tackled. Theoretical dependences are given, making it possible to determine the bearing capacity and temperature increase in the hydrostatic bearing. Quantitative values of specific pressures on the working surface of the bearing and an increase in the temperature of the working fluid due to friction and pumping losses were established.
It was found that the specific pressures of the liquid do not exceed the tensile strength of the bearing material. The reduction in load capacity due to an increase in the temperature of the working fluid was 10.95 %, owing to the small change in the temperature of the working fluid in hydrostatic bearings. The results of the study make it possible to establish the permissible boundaries for the purpose of the design and operational parameters of the hydrostatic bearing ensuring its operability.
For the effective use of hydrostatic wooden bearings at the listed facilities, it is necessary to have a system for supplying lubricant to the bearing under high pressure. The system should include filters to clean the lubricant from impurities. The theoretical dependences built allow designers of hydrostatic bearings to use them in practical calculations
Development of safety methods on artificial structures of railway lines
Authors: Akbayeva Assem , Muratbekova Gulzhan , Altayeva Zhanar , Bondar Ivan , Abibullayev Serik , Bekzhanova Saule , Kvashnin Mikhail
Published: January 2023

The numerous cases of deformation of technogenic objects in the transport industry under increasing axial loads and speeds of motion aggravate the need to solve the problems of early recognition of the nature and causes of deformations of structural elements. The need for this is due to the fact that destructions and accidents, resulting from deformation processes, cause enormous economic, social and environmental damage, incomparable with the funds spent on protective measures.
The object of the study in the article is a railway trestle, consisting of two spans of a ribbed reinforced concrete beam. Determination of the residual resource in terms of bearing capacity and load-carrying capacity of the railway trestle is the main task. The authors have obtained bending deformations (stresses), frequencies of natural vibrations and operating modes of structures of railway trestle spans. The damage degree of the railway overpass spans structures may also be judged by the deviation of the calculated values of the amplitude-phase-frequency characteristics (AFFR) from the standard values. The peculiarity of this research is the fact, that the natural frequencies of railway overpass vibrations are determined either by «tails» of experimental vibrograms (oscillograms) after the load release from the span structure. During the express-diagnostics of railway overpasses, the relative deformations (stresses) of girder spans in the middle of the span, the first frequency (period) of natural vibrations of girder reinforced concrete spans of railway overpasses are used as parameters characterizing the technical condition of the spans. The results of tests and examinations of overpasses to ensure their safe operation have been given
Antinociceptive effects of Treculia africana decne (african breadfruit) seed lectin in Wistar rats
Authors: Awe Joseph Obabiolorunkosi , Osukoya Olukemi Adetutu , Adewale Olusola Bolaji , Obafemi Tajudeen Olabisi , Afolabi Olakunle Bamikole , Kuku Adenike
Published: January 2023

The aim: The use of synthetic compounds to treat many diseases must be strictly controlled due to their potential health hazards. Hence, there is a need to search for natural products to serve as safe alternatives to synthetic products. This study investigated the antinociceptive effects and anti-inflammatory activities of Treculia africana seed lectin.

Materials and methods: Lectins were purified from Treculia africana seeds using ion exchange and size-exclusion chromatography. The antinociceptive activity of the lectin was assessed in Wistar rats using abdominal writhing and paw-licking tests induced by acetic acid and formalin, respectively. Anti-inflammatory activity was assessed using carrageenan-induced paw oedema.

Results: Treculia africana seed lectins at 10 mg/kg (p.o.) produced sedation, reduced ambulation, reduced response to touch, analgesia, and decreased defecation in experimental animals. Administration of Treculia africana seed lectin (1 mg/kg and 10 mg/kg) in experimental animals significantly reduced (P < 0.05) acetic acid-induced muscular writhing in a dose-dependent manner with 23.88 and 36.80 per cent inhibition, respectively. Both early and late phases of formalin-induced nociception were significantly inhibited (P < 0.001) by the lectin at all doses (0.1, 1.0 and 10.0 mg/kg), comparably with the standard drug, diclofenac sodium. At 10 mg/kg, T. africana lectin caused a 69.12 % and 65.55 % reduction in both early and late phases of formalin-induced paw licking. Treculia africana lectin also significantly brought about a reduction (P < 0.05) in inflammation induced by sub-plantar injection of carrageenan as measured by a decrease in paw swollenness.

Conclusion: The study showed that Treculia africana lectin possesses antinociceptive and anti-inflammatory properties and can potentially be employed therapeutics to ameliorate pain and inflammation
Justification of the composition and technology of combined tablets for the treatment of type II diabetes.
Authors: Kotvitska Alla , Ruban Olena , Volkova Alina , Kovalevska Inna , Kononenko Nadiia , Chikitkina Valentyna
Published: January 2023

The aim. The aim of the work was to establish the feasibility of development, determine the optimal composition and technology, and confirm the pharmacological effectiveness of combined tablets for treating type II diabetes.
Materials and methods. Analytical research of the pharmaceutical market of drugs used for the treatment of type II diabetes was carried out using content analysis of official sources of information. The subjects of the study were medicinal products used to treat type II diabetes. A set of physicochemical and technological research methods was used to determine the quality parameters of the tabletting mass and tablets based on them.
Results. According to the results of previous studies, similarities in the approaches to the pharmacotherapy of type II diabetes in the countries of Southeast Asia, the Western Pacific region, and Ukraine were established, which became the basis for conducting a market study of drugs with a sugar-lowering effect, namely, based on voglibose, with the aim of further including such drugs in the range of Ukrainian manufacturers. Furthermore, according to the results of physicochemical and technological studies, the composition and rational technology of obtaining tablets were established. Also, pharmacological studies have established that tablets with voglibose and solid dispersion of quercetin significantly prevent the development of glucose metabolism disorders caused by a high-sugar diet. In terms of the expressiveness of the hypocholesterolemic effect of the tablets and their constituent components, they are reliably superior to the comparison drug - metformin.
Conclusions. According to the research results, the feasibility and relevance of the development of combined tablets with voglibose and solid dispersion of quercetin have been established. Furthermore, based on the investigated physicochemical and technological indicators, combined tablets' composition and rational technology were developed, and their specific pharmacological activity was proven
Research of the influence of Melanizol pessaries on background of “chemical” vaginitis in rats
Authors: Dolzhykova Olena , Yeromenko Rymma
Published: January 2023

The aim. to study the therapeutic influence of new pessaries Melanizol based on metronidazole and tea tree oil on the background of model of “chemical” vaginitis in female rats.

Materials and methods. The therapeutic effect of pessaries Melanizol was studied in female rats on the model of "chemical" vaginitis with using argentum nitrate, which provokes vaginitis not burdened by infection. Against the background of vaginitis, the general condition of animals, the dynamics of body weight, the morphological composition of peripheral blood and the erythrocyte sedimentation rate (ESR), pH, biochemical parameters (total protein, ALT and glucose), temperature in the vagina of rats, macroscopically assessed changes in the vaginal mucosa (VM) were studied.

Results and discussion. Against the background of pathology in the animals, a shift in the studied indicators was observed. Pessaries Melanizol at the dose of 21 mg/kg make a therapeutic effect on the model of experimental "chemical" vaginitis, caused by argentum nitrate, as indicated by the restoration of the VM state, reduced the number of leukocytes, restored the percentage composition of the leukocyte formula, reduced the amount of total protein and the cytolytic enzyme ALT in blood serum and vaginal contents, which indicates the anti-inflammatory and cytoprotective effect of the studied agent. The recovery of vaginal temperature, pH and the amount of glucose in the vaginal contents was also observed, which indicates the normalization of homeostasis in the vagina of experimental animals. According to these effects, the studied pessaries Melanizol were superior to the reference drug "Gravagin" at the dose of 30 mg/kg and were not inferior to the reference drug Hippophaes oleum pessaries (HOP) at the dose of 17.64 mg/kg.

Conclusions. The therapeutic effect of new pessaries Melanizol based on metronidazole and tea tree oil on the model of "chemical" vaginitis in female rats has been proven. The investigated pessaries Melanizol are a promising drug for the treatment of non-specific vaginitis and require further research in this direction
Pharmacological study of original extracts of corn silk
Authors: Naboka Olga , Vyshnevska Liliia , Pasynchuk Inna , Filiptsova Olga , Tkachenko Oksana , Vislous Olha
Published: January 2023

Aim: the aim of the research is a pharmacological study of the original extracts of corn silk.
Materials and methods. The object of the study were 4 original extracts of corn silk, obtained by extraction with water and ethanol of different concentrations, namely: aqueous extract of corn silk (ACSE), extract of corn silk, extracted with ethanol 30 % (ECSE 30 %) , extract of corn silk, extracted with ethanol 50 % (ЕCSЕ 50 %), extract of corn silk, extracted with ethanol 70 % (ЕCSЕ 70 %). A screening study of the antioxidant properties of corn silk extracts was carried out in vitro using models of spontaneous and ascorbate-induced lipid peroxidation (LPO) in rat liver homogenate.
Results. As can be seen from the given data, ECSE 50 % at a dose of 20 mg/kg showed a pronounced protective effect on the hepatotoxicity of TСM. Its use led to a probable restoration of the bile-forming function of the liver against the background of tetrachloromethane hepatitis: in response to an increase in the cholesterol content (by 43 %, p<0.05), the content of bile acids increased 2 times (p<0.05), as a result of which cholate -cholesterol ratio approached the level of indicators of intact animals, the rate of bile secretion normalized. Based on the analysis of the results of the study, it can be concluded, that in terms of bile-forming and choleretic activity on the tetrachloromethane hepatitis model, ECSE 50 % was not inferior to silibor and superior to quercetin (р<0.05).
Conclusions. Biologically active substances of corn silk affect not only the diffusion and filtration processes of the liver parenchyma, but also the biosynthesis and transport of its organic components, that is, they affect the bile-forming function
Development of a risk management method for development projects of providers of housing and utility services
Authors: Chernenko Yuri , Haidaienko Oksana , Tkachenko Valentyn
Published: January 2023

The object of research in the work is the processes of anti-risk management of projects for the development of providers of housing and utility services (PHUS). Particular attention is required to limit the management of the activities of the PHUS, related to the specifics of the housing and utility services sector. They have a significant impact on the need for the PHUS to constantly adjust the direction of efforts. They force companies to constantly monitor the progress of their projects and redirect resources. The priority should be development projects with the highest and fastest financial results with minimal risks. An essential lever for improving the effectiveness of anti-risk management in the projects for the development of PHUS is the possibility of adjusting the priorities for the implementation of these projects as much as possible in real time.
This study developed a method of anti-risk management of development projects for housing and utility services providers, which consists in integrating such approaches into a single process, such as the implementation of management automation and decision-making algorithms. As well as the implementation of a process approach in risk management and decision making; implementation of benchmarking; and building a dynamic organizational structure for managing development projects
The scheme of the method of anti-risk management of projects for the development of housing and utility services providers includes the following steps:
– formation of a register of projects for the development of providers of housing and utility services;
– identification of limitations of projects for the development of providers of housing and utility services;
– implementation of automation of management and algorithmization of decision-making in the management of projects for the PHUS development;
– application of a process approach in risk management and decision-making in the management of projects for the PHUS development;
– building a dynamic organizational structure for managing development projects;
– implementation of benchmarking in the management of projects for the PHUS development;
– adjusting the PHUS priorities for the implementation of development projects in real time;
– increasing the effectiveness of anti-risk management by directing the main resources to the PHUS development projects with minimal risks and the most significant economic result.
The integration of all the above blocks into the anti-risk management of PHUS development projects makes it possible to increase the efficiency of managing these projects by directing the main resources to them with minimal risks and the most significant economic result. This, in turn, will improve the performance of providers of housing and utility services in terms of increasing income and reducing costs.
Research and comparative analysis of the qualitative parameters of food powders produced from grain raw materials using an improved jet mill
Authors: Changgao Sun , Olkhovikov Oleh , Xiaojin Gao , Marynin Andrii , Sichen Zhang , Shevchenko Anastasiia , Botong Sun , Yue Zhao
Published: January 2023

The object of the study is samples of food powders obtained by grinding the products of the collection and processing of a number of grain crops, using air-grinding technology in an improved jet mill. One of the most important problems of the modern food industry is that for the production of flour from cereals endosperm is used while the most important nutrients are found in shells and the germ of the grain.
As a result of its grinding in conventional mills, common at existing mills, large pieces of bran and a large variation in the particle size of the grinding products are obtained, and this method is energy-intensive.
According to the authors, the best solution to ensure truly whole grain grinding – that is, grinding grains with shells – is air grinding in jet mills. An improved jet mill makes it possible to grind both endosperm and grain shells into flour of the same consistency. From the same amount of raw material, therefore, it is possible to produce approximately 30 % more final grinding products. It is also important that the improved jet mill, under proven conditions, spends no more energy for grinding than a conventional mill.
For research, the most popular products ground in such a mill were taken – wheat flour (black grain), buckwheat flour (from roasted buckwheat) and wheat bran. The first two products are whole grain milled, and the bran is produced from the collapse of wheat grown in accordance with the requirements of organic farming. Samples of powders obtained by grinding these products in an improved jet mill were compared with control samples – produced from similar raw materials in a roller mill – the most common design in service with mills. Physical indicators of the powders, thermophysical properties and biotechnological parameters were carried out.
The obtained results allow to state that whole grain grinding produced on an improved jet mill has the characteristics better or close to standard types of flour produced on conventional mills. It allows them to be used without significant changes in the formulation of products with their addition (bakery, pasta, etc.), and also to create new dietary, healthy products rich in biologically active substances.
“Ugarit (Ras Shamra): Culturas e sociedade mediterrâneas” - Apresentação ensaística do Dossiê
Authors: Santos João Batista Ribeiro
Published: January 2023

Apresentação do dossiê
“Ugarit (Ras Shamra): Culturas y sociedad mediterráneas” – Ensayo presentación del Dossier
Authors: Santos João Batista Ribeiro
Published: January 2023

Presentación del Dossier
Reinado, entre a vida e a morte: Apontamentos sobre o “Épico de Kirta” e suas relações com a Bíblia Hebraica
Authors: Rocha Matheus Eduardo De Oliveira
Published: January 2023

As recentes escavações e pesquisas relativas à antiga cidade de Ugarit têm expandido os horizontes de compreensão sobre a religião, literatura e organização social no Levante. Desse modo, o presente trabalho se empenha na análise de um mito ugarítico nomeado como “Épico de Kirta”, o qual narra as agruras que sobrevieram ao personagem homônimo e seu reinado. Para tanto, a primeira parte do artigo se ocupa em apresentar as questões históricas e arqueológicas que circundam a obra, bem como indica as principais tendências interpretativas de sua leitura. Em seguida, delineiam-se apontamentos que sintetizam seu enredo e analisam a sua construção narrativa, possibilitando uma percepção mais clara do texto. Por fim, demonstram-se algumas possíveis relações entre o épico aqui analisado e trechos da Bíblia Hebraica. Nessa perspectiva, compreendeu-se a pluralidade e dialogicidade como elementos basilares na construção do imaginário religioso e das manifestações culturais nessa região.
ESTIMATED DETERMINATION OF PARAMETERS OF MOUNTING MASTS
Authors: Soldatenko L. , Shipko A. , Shipko I.
Published: January 2023

When carrying out installation work at the enterprises of the branch, the use of universal lifting equipment is sometimes impossible or impractical. In such cases, resort to the use of mounting masts - relatively simple in design and quite efficient lifting equipment [1], the construction of which is largely based on the practical experience of foremen of assembly organizations or fore-men-riggers. Existing methods of calculation of mounting masts, developed many decades ago on the basis of sufficiently primitive considerations, without taking into account additional loads, give approximate results and should be revised and improved. An attempt at such work is reflected in this article. Since the main structural elements of the mounting mast are its riser and cables, the definition of the parameters of the mast is to calculate the strength of the riser and cables of the accepted dimensions under the loads provided by the initial data of a specific technical task. Evaluation of the strength of the riser should be performed both in the plane of torque and from the plane of torque. To find the value of the maximum stress in the mast riser and the maximum stress in the i-th cable, it is necessary to calculate the stress-strain state of the riser and cables using a mixed method, according to which some unknowns are displacement and part - effort. The mathematical model of the problem is described by four algebraic equations. The equation of continuity of riser deformations is based on the use of Tymoshenko's functions, which take into account the influence of longitudinal forces on the deflection of the mast riser in the plane of action of wind load and weight of cargo. Loads from the weight and tension of the cables are taken into account their possible ice and the force of pre-tension. The wind load of the riser and cables is determined using data on the standard speed pressure, N / m2, which for Ukraine is 0.38 kPa. Calculations of riser and cable parameters also take into account the temperature difference, which in the climatic conditions of Ukraine does not exceed the interval 040 st structures are recommended to rely on the combination of both permanent and temporary loads according to the data given in the article. All this together gives reason to hope that the considered method of calculation of parameters of assembly masts will be useful to experts of the assembly organizations and students studying questions of technics and technology of rigging works.
Депортація польського населення з території УРСР. 1944–1946 рр
Authors:   Taras Shevchenko National University of Kyiv, Сорока Юрій
Published: January 2023

This article studies №6 process of resettlement of the Polish population from the territory of the USSR in accordance with №6 Lublin's Agreement of September 9, 1944.