bluuebunny/crossref_metadata_2025 huggingface dataset:
Cyborgian Approach of Eco-interaction Design Based on Machine Intelligence and Embodied Experience
Authors: Yi Guyi , Di Carlo Ilaria
Published: January 2021

The proliferation of digital technology has swelled the amount of time people spent in cyberspace and weakened our sensibility of the physical world. Human beings in this digital era are already cyborgs as the smart devices have become an integral part of our life. Imagining a future where human totally give up mobile phones and embrace nature is neither realistic nor reasonable. What we should aim to explore is the opportunities and capabilities of digital technology in terms of fighting against its own negative effect - cyber addiction, and working as a catalyst that re-embeds human into outdoor world.

Cyborgian systems behave through embedded intelligence in the environment and discrete wearable devices for human. In this way, cyborgian approach enables designers to take advantages of digital technologies to achieve two objectives: one is to improve the quality of environment by enhancing our understanding of non-human creatures; the other is to encourage a proper level of human participation without disturbing eco-balance.

Finally, this paper proposed a cyborgian eco-interaction design model which combines top-down and bottom-up logics and is organized by the Internet of Things, so as to provide a possible solution to the concern that technologies are isolating human and nature.
Demonstration of background rejection using deep convolutional neural networks in the NEXT experiment
Authors:   The NEXT collaboration, Kekic M. , Adams C. , Woodruff K. , Renner J. , Church E. , Del Tutto M. , Hernando Morata J. A. , Gómez-Cadenas J. J. , Álvarez V. , Arazi L. , Arnquist I. J. , Azevedo C. D. R. , Bailey K. , Ballester F. , Benlloch-Rodríguez J. M. , Borges F. I. G. M. , Byrnes N. , Cárcel S. , Carrión J. V. , Cebrián S. , Conde C. A. N. , Contreras T. , Díaz G. , Díaz J. , Diesburg M. , Escada J. , Esteve R. , Felkai R. , Fernandes A. F. M. , Fernandes L. M. P. , Ferrario P. , Ferreira A. L. , Freitas E. D. C. , Generowicz J. , Ghosh S. , Goldschmidt A. , González-Díaz D. , Guenette R. , Gutiérrez R. M. , Haefner J. , Hafidi K. , Hauptman J. , Henriques C. A. O. , Herrero P. , Herrero V. , Ifergan Y. , Jones B. J. P. , Labarga L. , Laing A. , Lebrun P. , López-March N. , Losada M. , Mano R. D. P. , Martín-Albo J. , Martínez A. , Martínez-Lema G. , Martínez-Vara M. , McDonald A. D. , Meziani Z.-E. , Monrabal F. , Monteiro C. M. B. , Mora F. J. , Muñoz Vidal J. , Novella P. , Nygren D. R. , Palmeiro B. , Para A. , Pérez J. , Querol M. , Redwine A. B. , Ripoll L. , Rodríguez García Y. , Rodríguez J. , Rogers L. , Romeo B. , Romo-Luque C. , Santos F. P. , dos Santos J. M. F. , Simón A. , Sofka C. , Sorel M. , Stiegler T. , Toledo J. F. , Torrent J. , Usón A. , Veloso J. F. C. A. , Webb R. , Weiss-Babai R. , White J. T. , Yahlali N.
Published: January 2021

Abstract

Convolutional neural networks (CNNs) are widely used state-of-the-art computer vision tools that are becoming increasingly popular in high-energy physics. In this paper, we attempt to understand the potential of CNNs for event classification in the NEXT experiment, which will search for neutrinoless double-beta decay in 136Xe. To do so, we demonstrate the usage of CNNs for the identification of electron-positron pair production events, which exhibit a topology similar to that of a neutrinoless double-beta decay event. These events were produced in the NEXT-White high-pressure xenon TPC using 2.6 MeV gamma rays from a 228Th calibration source. We train a network on Monte Carlo-simulated events and show that, by applying on-the-fly data augmentation, the network can be made robust against differences between simulation and data. The use of CNNs offers significant improvement in signal efficiency and background rejection when compared to previous non-CNN-based analyses.
Vertrauen der Bevölkerung in staatliche Institutionen im ersten Halbjahr der Coronapandemie: Erkenntnisse aus dem Projekt COVID-19 Snapshot Monitoring (COSMO)
Authors: Eitze Sarah , Felgendreff Lisa , Korn Lars , Sprengholz Philipp , Allen Jennifer , Jenny Miriam A. , Wieler Lothar H. , Thaiss Heidrun , De Bock Freia , Betsch Cornelia
Published: January 2021

Hintergrund

In der Coronaviruspandemie nehmen 2 Institutionen eine zentrale Rolle in der evidenzbasierten Einordnung des Geschehens für Politik und Bevölkerung ein. Das Robert Koch-Institut (RKI) koordiniert die Pandemiebekämpfung, erstellt fundierte Empfehlungen für medizinisches Fachpersonal, die Medien sowie die Bevölkerung und berät die Politik. Die Bundeszentrale für gesundheitliche Aufklärung (BZgA) informiert die Bevölkerung und Institutionen.

Ziel der Arbeit

Mit dem COVID-19 Snapshot Monitoring (COSMO) wird beobachtet, ob und wie sich das Vertrauen in Institutionen über die Pandemie verändert. Es wird untersucht, welche Bevölkerungsgruppen Vertrauen zeigen und wie dies mit Einstellungen, Risikowahrnehmung und Verhaltensweisen zusammenhängt.

Material und Methoden

In Querschnittstudien werden seit März 2020 die Risikowahrnehmung, das Verhalten und die Akzeptanz von Maßnahmen sowie das Vertrauen in Institutionen mit etwa N = 1000 Befragten pro Erhebung untersucht.

Ergebnisse

Das Vertrauen in RKI und BZgA war generell hoch, sank aber über den Verlauf der Pandemie. Höheres Vertrauen ging für beide Institutionen mit höherem Alter der Befragten, höherer Bildung, höherer Risikowahrnehmung und höherer Akzeptanz von Maßnahmen einher.

Verhaltensweisen wie Abstandhalten und Händewaschen wurden häufiger gezeigt. Männer und chronisch Erkrankte zeigten geringeres Vertrauen.

Diskussion

Die Ergebnisse zeigen, dass Vertrauen weiter gefördert werden sollte. Dies könnte u. a. erreicht werden, indem in der Entwicklung und Begründung von Strategien und Maßnahmen auch die Sichtweise der Bevölkerung (z. B. durch COSMO) berücksichtigt wird. Kommunikationsstrategien und Handlungsempfehlungen sollten darauf abzielen, Personen mit hoher Risikowahrnehmung zu unterstützen und zu entlasten.
Ultra-low radiation dose protocol for CT-guided intrathecal nusinersen injections for patients with spinal muscular atrophy and severe scoliosis
Authors: Rosiak Grzegorz , Lusakowska Anna , Milczarek Krzysztof , Konecki Dariusz , Fraczek Anna , Rowinski Olgierd , Kostera-Pruszczyk Anna
Published: January 2021

Purpose

Intrathecal injection of nusinersen is an approved treatment of spinal muscular atrophy (SMA). CT-guided injection is a method of nusinersen administration in patients with severe scoliosis, in whom standard lumbar puncture is not feasible. The injections are repeated every 4 months for life, and accumulated radiation doses absorbed by the patient can increase the risk of cancer. In this study, we present the results of CT-guided intrathecal nusinersen injections with an ultra-low radiation dose protocol.

Methods

Eighteen patients (15 adults and three children) in whom standard lumbar puncture was not feasible due to severe scoliosis or spinal stabilization were included in this retrospective study. The first 23 injections were performed with a standard radiation dose protocol and the next 42 injections with an ultra-low-dose protocol. The radiation doses, measured as total dose length product (DLP), were acquired and compared between the protocols.

Results

Injections were successful in 100% of patients with both ultra-low-dose and standard protocols. The radiation dose, measured as DLP, was 111.2–1100.7 (Me = 248.1) mGy*cm for the standard protocol. For the ultra-low-dose protocol, the dose range was 5.0–54.4 (Me = 26.7) mGy*cm, which was significantly lower than with the standard protocol (p < 0.001, η2 = 0.67).

Conclusion

Radiation doses can be significantly decreased in the CT-guided injection of nusinersen. The proposed protocol allows for effective CT-guided intrathecal nusinersen administration in patients with SMA and severe scoliosis.
Activity of tumor-associated macrophage depletion by CSF1R blockade is highly dependent on the tumor model and timing of treatment
Authors: O’Brien Sarah A. , Orf Jessica , Skrzypczynska Katarzyna M. , Tan Hong , Kim Jennie , DeVoss Jason , Belmontes Brian , Egen Jackson G.
Published: January 2021

Tumor-associated macrophages (TAMs) are abundant in solid tumors where they exhibit immunosuppressive and pro-tumorigenic functions. Inhibition of TAM proliferation and survival through CSF1R blockade has been widely explored as a cancer immunotherapy. To further define mechanisms regulating CSF1R-targeted therapies, we systematically evaluated the effect of anti-CSF1R treatment on tumor growth and tumor microenvironment (TME) inflammation across multiple murine models. Despite substantial macrophage depletion, anti-CSF1R had minimal effects on the anti-tumor immune response in mice bearing established tumors. In contrast, anti-CSF1R treatment concurrent with tumor implantation resulted in more robust tumor growth inhibition and evidence of enhanced anti-tumor immunity. Our findings suggest only minor contributions of CSF1R-dependent TAMs to the inflammatory state of the TME in established tumors, that immune landscape heterogeneity across different tumor models can influence anti-CSF1R activity, and that alternative treatment schedules and/or TAM depletion strategies may be needed to maximize the clinical benefit of this approach.
Molecular Lymph Node Staging with One‐Step Nucleic Acid Amplification and its Prognostic Value for Patients with Colon Cancer: The First Follow‐up Study
Authors: Weixler Benjamin , Teixeira da Cunha Sofia , Warschkow René , Demartines Nicolas , Güller Ulrich , Zettl Andreas , Vahrmeijer Alexander , van de Velde Cornelis J. H. , Viehl Carsten T. , Zuber Markus
Published: January 2021

Background

Molecular lymph node workup with one‐step nucleic acid amplification (OSNA) is a validated diagnostic adjunct in breast cancer and also appealing for colon cancer (CC) staging. This study, for the first time, evaluates the prognostic value of OSNA in CC.

Patients and methods

The retrospective study includes patients with stage I‐III CC from three centres. Lymph nodes were investigated with haematoxylin and eosin (H&E) and with OSNA, applying a 250 copies/μL threshold of CK19 mRNA. Diagnostic value of H&E and OSNA was assessed by survival analysis, sensitivity, specificity and time‐dependent receiver operating characteristic curves.

Results

Eighty‐seven patients were included [mean follow‐up 53.4 months (± 24.9)]. Disease recurrence occurred in 16.1% after 19.8 months (± 12.3). Staging with H&E independently predicted worse cancer‐specific survival in multivariate analysis (HR = 10.77, 95% CI 1.07–108.7, p = 0.019) but not OSNA (HR = 3.08, 95% CI 0.26–36.07, p = 0.197). With cancer‐specific death or recurrence as gold standard, H&E sensitivity was 46.7% (95% CI 21.3–73.4%) and specificity 84.7% (95% CI 74.3–92.1%). OSNA sensitivity and specificity were 60.0% (95% CI 32.3–83.7%) and 75.0% (95% CI 63.4–84.5%), respectively.

Conclusions

In patients with CC, OSNA does not add relevant prognostic value to conventional H&E contrasting findings in other cancers. Further studies should assess lower thresholds for OSNA (< 250 copies/μL).
Summer circumpolar acoustic occurrence and call rates of Ross, Ommatophoca rossii, and leopard, Hydrurga leptonyx, seals in the Southern Ocean
Authors: Shabangu Fannie W. , Rogers Tracey L.
Published: January 2021

Two of the Antarctic pack ice seals, Ross,Ommatophoca rossii, and leopard,Hydrurga leptonyx,seals, are extremely difficult to study via traditional visual survey techniques, yet are ideal for an acoustic survey as they are highly vociferous and produce an array of underwater sounds during the austral summer. To determine their acoustic occurrence in the Antarctic pack ice, we use their calls, detected within 680 acoustic recordings made between 1999 and 2009 as part of two multinational programmes. Siren calls of Ross seals were detected mainly in January, and 9.88 calls per minute from low siren calls was the highest call rate for this species. High numbers of Ross seal calls were detected close to the ice edge in areas between 0° and 20° E and 60° and 130° E, suggesting these are important summer habitats. Leopard seal calls were detected mainly in December and January, and December had the highest percentage of calls. Call rate of 11.93 calls per minute from low double trills was the highest call rate for leopard seals. Leopard seal calls were detected throughout the Southern Ocean with more calls detected throughout the pack ice. There was little spatio-temporal overlap in call occurrence of Ross and leopard seals, but both species were more vocally active during the day. Longitude and latitude were the most important predictors of Ross seal occurrence, and month of the year highly predicted leopard seal occurrence. This is the first study to examine the circumpolar acoustic occurrence of Ross and leopard seals in the Southern Ocean pack ice.
Reliability of the MOCART (Magnetic Resonance Observation of Cartilage Repair Tissue) 2.0 knee score for different cartilage repair techniques—a retrospective observational study
Authors: Schreiner Markus M. , Raudner Marcus , Röhrich Sebastian , Zalaudek Martin , Weber Michael , Kaiser Georg , Aldrian Silke , Chiari Catharina , Windhager Reinhard , Trattnig Siegfried
Published: January 2021

Objectives

To evaluate the reliability of the MOCART 2.0 knee score in the radiological assessment of repair tissue after different cartilage repair procedures.

Methods

A total of 114 patients (34 females) who underwent cartilage repair of a femoral cartilage lesion with at least one postoperative MRI examination were selected, and one random postoperative MRI examination was retrospectively included. Mean age was 32.5 ± 9.6 years at time of surgery. Overall, 66 chondral and 48 osteochondral lesions were included in the study. Forty-eight patients were treated with autologous chondrocyte implantation (ACI), 27 via osteochondral autologous transplantation, five using an osteochondral scaffold, and 34 underwent microfracture (MFX). The original MOCART and MOCART 2.0 knee scores were assessed by two independent readers. After a minimum 4-week interval, both readers performed a second reading of both scores. Inter- and intrarater reliabilities were assessed using intraclass correlation coefficients (ICCs).

Results

The MOCART 2.0 knee score showed higher interrater reliability than the original MOCART score with an ICC of 0.875 versus 0.759, ranging from 0.863 in the MFX group to 0.878 in the ACI group. Intrarater reliability was good with an overall ICC of 0.860 and 0.866, respectively. Overall, interrater reliability was higher for osteochondral lesions than for chondral lesions, with ICCs of 0.906 versus 0.786.

Conclusions

The MOCART 2.0 knee score enables the assessment of cartilage repair tissue after different cartilage repair techniques (ACI, osteochondral repair techniques, MFX), as well as for different lesion types with good intra- and interrater reliability.

Key Points

• The MOCART 2.0 knee score provides improved intra- and interrater reliability when compared to the original MOCART score.

• The MOCART 2.0 knee score enables the assessment of cartilage repair tissue after different cartilage repair techniques (ACI, osteochondral repair techniques, MFX) with similarly good intra- and interrater reliability.

• The assessment of osteochondral lesions demonstrated better intra- and interrater reliability than the assessment of chondral lesions in this study.
Sneddon syndrome: a comprehensive clinical review of 53 patients
Authors: Starmans N. L. P. , van Dijk M. R. , Kappelle L. J. , Frijns C. J. M.
Published: January 2021

Background

The presence of livedo reticularis in patients with ischaemic stroke is associated with Sneddon syndrome (SS). Our objective was to present the clinical features of SS patients and to assess the role of antiphospholipid antibodies (APL).

Methods

Consecutive patients, diagnosed with SS between 1996 and 2017, were retrospectively reviewed for their demographic, neurological, dermatological, cardiac and extracerebral vascular features. Diagnosis of SS was made only if other causes of stroke were excluded. Patients with and without APL were included and compared for their clinical features.

Results

Fifty-three patients (79% female) were included, of whom 14 patients were APL-positive. Median age at diagnosis was 40 years. Approximately 60% of the patients had ≥ 3 cardiovascular risk factors. There were 129 previous vascular events (66 ischaemic strokes, 62 TIAs and 1 amaurosis fugax) during a median period of 2 years between the first event and diagnosis of SS. Skin biopsy was positive for SS in 29 patients (67%), mostly showing a thickened vessel wall with neovascularization in the deep dermis. After a median follow-up of 28 months, 4 patients, either on antiplatelet or oral anticoagulation therapy, had a recurrent stroke. There were few statistically significant differences between APL-negative and APL-positive patients, including the number of vascular events before diagnosis.

Conclusions

SS predominantly affects young women with a relatively large number of cardiovascular risk factors. Clinical features of SS are comparable across different studies. We found no differences in the main clinical features between APL-positive and APL-negative patients.
Advanced lung cancer inflammation index and its prognostic value in HPV-negative head and neck squamous cell carcinoma: a multicentre study
Authors: Gaudioso Piergiorgio , Borsetto Daniele , Tirelli Giancarlo , Tofanelli Margherita , Cragnolini Fiordaliso , Menegaldo Anna , Fabbris Cristoforo , Molteni Gabriele , Marchioni Daniele , Nicolai Piero , Bossi Paolo , Ciorba Andrea , Pelucchi Stefano , Bianchini Chiara , Mauramati Simone , Benazzo Marco , Giacomarra Vittorio , Di Carlo Roberto , Sethi Mantegh , Polesel Jerry , Fussey Jonathan , Boscolo-Rizzo Paolo
Published: January 2021

Purpose

The aim of this study is to evaluate the prognostic value of pre-treatment advanced lung cancer inflammation index (ALI) in patients with HPV-negative HNSCC undergoing up-front surgical treatment.

Methods

The present multi-centre, retrospective study was performed in a consecutive cohort of patients who underwent upfront surgery with or without adjuvant (chemo)-radiotherapy for head and neck squamous cell carcinoma (HNSCC). Patients were stratified by ALI, and survival outcomes were compared between groups. In addition, the prognostic value of ALI was compared with two other indices, the prognostic nutritional index (PNI) and systemic inflammatory index (SIM).

Results

Two hundred twenty-three patients met the inclusion criteria (151 male and 72 female). Overall and progression-free survival were significantly predicted by ALI < 20.4 (HR 3.23, CI 1.51–6.90 for PFS and HR 3.41, CI 1.47–7.91 for OS). Similarly, PNI < 40.5 (HR = 2.43, 95% CI: 1.31–4.51 for PFS and HR = 2.40, 95% CI: 1.19–4.82 for OS) and SIM > 2.5 (HR = 2.51, 95% CI: 1.23–5.10 for PFS and HR = 2.60, 95% CI: 1.19–5.67 for OS) were found to be significant predictors. Among the three indices, ALI < 20.4 identified the patients with the worst 5-year outcomes. Moreover, patients with a combination of low PNI and low ALI resulted to be a better predictor of progression (HR = 5.26, 95% CI: 2.01–13.73) and death (HR = 5.68, 95% CI: 1.92–16.79) than low ALI and low PNI considered alone.

Conclusions

Our results support the use of pre-treatment ALI, an easily measurable inflammatory/nutritional index, in daily clinical practice to improve prognostic stratification in surgically treated HPV-negative HNSCC.
The black box of regional growth
Authors: Grillitsch Markus , Martynovich Mikhail , Fitjar Rune Dahl , Haus-Reve Silje
Published: January 2021

Regional growth models leave a large share of variation unexplained. While we should continuously aim to improve these models, the unique combination of conditions and human agency in each region will also invariably lead to region-specific growth trajectories. Theoretically, we should thus expect systematic deviations from growth predictions. We propose an approach to explore these unexplained deviations and to detect regions that perform unexpectedly well or badly in certain periods. We illustrate the approach using data for Sweden from 1990 to 2016. We find systematic patterns of unexplained periodic regional growth deviations outweighing the effect of generic structural factors.
Omental metastasis as a predictive risk factor for unfavorable prognosis in patients with stage III–IV epithelial ovarian cancer
Authors: Iwagoi Yutaka , Motohara Takeshi , Hwang Sangyoon , Fujimoto Koichi , Ikeda Tokunori , Katabuchi Hidetaka
Published: January 2021

Background

Epithelial ovarian cancer has a clear predilection for the omentum as the site of metastasis; however, its contribution to clinical outcomes remains unresolved. This study aimed to evaluate the prognostic significance and efficacy of chemotherapy in the presence of omental metastasis.

Methods

A retrospective cohort study was performed in 56 patients with stage III–IV ovarian cancer who underwent primary debulking surgery between 2004 and 2018 at Kumamoto University Hospital.

Results

Thirty-six (64.3%) patients were categorized into the omental metastasis-positive group, whereas 20 (35.7%) patients were in the omental metastasis-negative group. The 5-year overall survival rates were 43.4% in the omental metastasis-positive group and 93.8% in the omental metastasis-negative group. Statistically significant differences were observed in overall survival (p = 0.002) and progression-free survival (p = 0.036) between the omental metastasis-positive and metastasis-negative groups. Notably, multivariate analysis demonstrated that the existence of omental metastasis is an independent risk factor for overall survival in patients with stage III–IV ovarian cancer (hazard ratio 8.90, 95% confidence interval 1.16–69.77; p = 0.038). Furthermore, the omental metastasis-positive group had significantly lower overall response rates to chemotherapy for recurrent disease, compared to the omental metastasis-negative group (31.6% vs. 85.7%, p = 0.026).

Conclusion

Our present data demonstrated that omental metastasis is closely associated with an unfavorable prognosis due to increased chemoresistance in patients with stage III–IV ovarian cancer. Elucidating the biological mechanism of omental metastasis will shed light on novel therapeutic approaches for the management of advanced ovarian cancer patients.
Kallosotomien bei Sturzanfällen und epileptischen Spasmen
Authors: Klotz Kerstin Alexandra , Scheiwe Christian , Reinacher Peter , Antonio-Arce Victoria San , Schulze-Bonhage Andreas , Demerath Theo , Shah Mukesch
Published: January 2021

Die Kallosotomie ist eine palliative Operation, die seit fast 80 Jahren bei Patienten mit therapierefraktären, bilateralen Anfällen eingesetzt wird, wenn ein resektives Verfahren nicht möglich ist. Neuere, minimal-invasive Techniken wie die MRT-gesteuerte laserinduzierte Thermokoagulation sind vermutlich vergleichbar bezüglich Outcome und Komplikationsraten, die Datenlage ist aber insgesamt noch spärlich. In vielen Fallserien war die Kallosotomie v. a. in der Reduktion von Sturzanfällen effektiv, in geringerem Ausmaß auch für epileptische Spasmen. Eine vollständige Anfallsfreiheit wird nur sehr selten erreicht. Chirurgische Komplikationen wie Blutungen oder Infektionen treten in etwa 5 % auf. Die wichtigste, jedoch sehr seltene Nebenwirkung der Kallosotomie ist ein Diskonnektionssyndrom mit Apraxie, taktiler und visueller Anomie, Neglect oder SMA(supplementär-motorisches Areal)-Syndrom. Besonders bei Kindern ist das Diskonnektionssyndrom in aller Regel transient. Ob eine anteriore oder eine komplette Kallosotomie durchgeführt wird, variiert von Zentrum zu Zentrum. Komplette Kallosotomien sind hinsichtlich der Anfallsreduktion effizienter, gehen aber mit einem höheren Risiko für Komplikationen und Nebenwirkungen einher. Eine Option ist eine zweistufige Kallosotomie, bei der zunächst eine anteriore Diskonnektion durchgeführt wird und in den Fällen ohne hinreichenden postoperativen Nutzen in einem zweiten Schritt vervollständigt wird.
Coexistence of rice production and threatened plant species: testing Marsilea quadrifolia L. in N-Italy
Authors: Corli Anna , Orsenigo Simone , Gerdol Renato , Bocchi Stefano , Smolders Alfons P. , Brancaleoni Lisa , Caffi Maria Teresa , Abeli Thomas , Rossi Graziano
Published: January 2021

In the past, the aquatic pteridophyte Marsilea quadrifolia L. was considered as a weed in paddy fields of southern Europe. The systematic use of herbicides as a crucial component of intensive agronomic approach has led to a dramatic decline in M. quadrifolia populations in European countries, mostly in the Mediterranean area. However, the introduction in recent years of sustainable rice cultivation practices has allowed partial recovery. We present here the results of a research aimed at analyzing the effects of farming typologies in respect to M. quadrifolia growth in the Po Valley area. After having transplanted M. quadrifolia swards in rice fields belonging to different farming systems, we monitored its growth and diffusion. Our results showed that M. quadrifolia has higher vegetative performance in organic farms, even though it can survive in conventional fields with reduced herbicide supply. Differences in water chemistry have limited effects on M. quadrifolia performance, because of its wide ecological amplitude. The shady conditions provided by rice canopy create micro-habitats suitable for M. quadrifolia growth. Cultivating M. quadrifolia in organic rice farms represents an important opportunity for preserving this endangered species in areas of intensive agriculture. This can, meanwhile, represent a valid opportunity to combine nature conservation and productivity offering a new possible income for farmers.
Reproducibility in speech rate convergence experiments
Authors: Fuscone Simone , Favre Benoit , Prévot Laurent
Published: January 2021

The reproducibility of scientific studies grounded on language corpora requires approaching each step carefully, from data selection and pre-processing to significance testing. In this paper, we report on our reproduction of a recent study based on a well-known conversational corpus (Switchboard). The reproduced study Cohen Priva et al. (J Acoust Soc Am 141(5):2989–2996, 2017) focuses on speech rate convergence between speakers in conversation. While our reproduction confirms the main result of the original study, it also shows interesting variations in the details. In addition, we tested the original study for the robustness of its data selection and pre-processing, as well as the underlying model of speech rate, the variable observed. Our analysis shows that another approach is needed to take into account the complex aspects of speech rate in conversations. Another benefit of reproducing previous studies is to take analysis a step further, testing and strengthening the results of other research teams and increasing the validity and visibility of interesting studies and results. In this line, we also created a notebook of pre-processing and analysis scripts which is available online.
Determinants of judges’ career choices and productivity: a Polish case study
Authors: Banasik Przemysław , Metelska-Szaniawska Katarzyna , Godlewska Małgorzata , Morawska Sylwia
Published: January 2021

The goal of this paper is to identify factors which affect judges’ productivity and career choice motives with the view of increasing judicial efficiency. Specifically, the investigation focuses on such aspects as judges’ remuneration, promotion, threat of judgment revocation, service/mission, periodic assessment, the threat of a complaint about protracted proceedings or of disciplinary proceedings, the threat of destabilization of the employment relationship, status/prestige of the profession, power/authority, social recognition, leisure, as well as administrative supervision and self-monitoring. To this end, a survey was conducted among judges of three of the largest Polish regional courts and subordinate district courts. The descriptive and statistical analyses show that judges’ care for the number of cases resolved, proxying for their productivity, is significantly correlated with self-monitoring of their adjudication activity. The stability of employment, the status/prestige of the profession and a relatively high remuneration are the most important factors in terms of judges’ career choices. In their care for the number of cases resolved remuneration is, albeit, no longer a relevant factor. Judges monitor their productivity due to reasons other than remuneration, possibly the sense of service/mission and the threat of various adverse consequences, the evidence for which is, however, also rather weak.
Standard electronic health record (EHR) framework for Indian healthcare system
Authors: Pai Manohara M. M. , Ganiga Raghavendra , Pai Radhika M. , Sinha Rajesh Kumar
Published: January 2021

Digitization of health records in public health facility and its instant availability in the form of electronic records anywhere any time health service is yet to be implemented in developing nations like India and other countries. In India, patient care is mainly delivered through 3 levels namely Primary/Community Healthcare Centre (PHC/CHC), Secondary healthcare centre (District Hospital), and Tertiary Healthcare Centre (National level). The healthcare facilities face many challenges in collecting, processing, and storing these data and managing it without compromising security and privacy. Presently, some of the secondary and tertiary care facilities have started implementing healthcare IT application in terms of Hospital Information System, Hospital Management Information System, Electronic Medical Records (EMR) etc. to manage the patient data in electronic format. However, these systems are developed by different vendors by using different programming languages and databases. This approach makes the system unique but the patient details remains in the same hospital and cannot be shared with other hospitals when patient moves from one hospital to other for advanced or specialized treatment. This is because the data is not interoperable and semantic. In the proposed work, a standard secure Electronic Health Record(EHR) framework is developed using standard medical terminology and coding standards. Implementation of EHR framework for Indian health system will improve the work-flow of health services to the population. EHR at all levels of healthcare system enable efficient and continuous care to the patient.
Complication rates following ventricular tachycardia ablation in ischaemic and non-ischaemic cardiomyopathies: a systematic review
Authors: Ding Wern Yew , Pearman Charles M. , Bonnett Laura , Adlan Ahmed , Chin Shui Hao , Denham Nathan , Modi Simon , Todd Derick , Hall Mark C. S. , Mahida Saagar
Published: January 2021

Background

Catheter ablation of ventricular tachycardia (VT) is associated with potential major complications, including mortality. The risk of acute complications in patients with ischaemic cardiomyopathy (ICM) and non-ischaemic cardiomyopathy (NICM) has not been systematically evaluated.

Methods

PubMed was searched for studies of catheter ablation of VT published between September 2009 and September 2019. Pre-specified primary outcomes were (1) rate of major acute complications, including death, and (2) mortality rate.

Results

A total of 7395 references were evaluated for relevance. From this, 50 studies with a total of 3833 patients undergoing 4319 VT ablation procedures fulfilled the inclusion criteria (mean age 59 years; male 82%; 2363 [62%] ICM; 1470 [38%] NICM). The overall major complication rate in ICM cohorts was 9.4% (95% CI, 8.1–10.7) and NICM cohorts was 7.1% (95% CI, 6.0–8.3). Reported complication rates were highly variable between studies (ICM I2 = 90%; NICM I2 = 89%). Vascular complications (ICM 2.5% [95% CI, 1.9–3.1]; NICM 1.2% [95% CI, 0.7–1.7]) and cerebrovascular events (ICM 0.5% [95% CI, 0.2–0.7]; NICM, 0.1% [95% CI, 0–0.2]) were significantly higher in ICM cohorts. Acute mortality rates in the ICM and NICM cohorts were low (ICM 0.9% [95% CI, 0.5–1.3]; NICM 0.6% [95% CI, 0.3–1.0]) with the majority of overall deaths (ICM 75%; NICM 80%) due to either recurrent VT or cardiogenic shock.

Conclusion

Overall acute complication rates of VT ablation are comparable between ICM and NICM patients. However, the pattern and predictors of complications vary depending on the underlying cardiomyopathy.
In situ nanoindentation during electrochemical hydrogen charging: a comparison between front-side and a novel back-side charging approach
Authors: Duarte M. J. , Fang X. , Rao J. , Krieger W. , Brinckmann S. , Dehm G.
Published: January 2021

The effects of hydrogen in metals are a pressing issue causing severe economic losses due to material deterioration by hydrogen embrittlement. A crucial understanding of the interactions of hydrogen with different microstructure features can be reached by nanoindentation due to the small volumes probed. Even more, in situ testing while charging the sample with hydrogen prevents the formation of concentration gradients due to hydrogen desorption. Two custom electrochemical cells for in situ testing were built in-house to charge the sample with hydrogen during nanoindentation: “front-side” charging with the sample and the indenter tip immersed into the electrolyte, and “back-side” charging where the analyzed region is never in contact with the solution. During front-side charging, surface degradation often occurs which also negatively influences analyses after hydrogen charging. The back-side charging approach proposed in this work is a promising technique for studying in situ the effects of hydrogen in alloys under mechanical loads, while completely excluding the influence of the electrolyte on the nanoindented surface. Hydrogen diffusion from the charged back-side toward the testing surface is here demonstrated by Kelvin probe measurements in ferritic FeCr alloys, used as a case study due to the high mobility of hydrogen in the bcc lattice. During nanoindentation, a reduction on the shear stress necessary for dislocations nucleation due to hydrogen was observed using both setups; however, the quantitative data differs and a contradictory behavior was found in hardness measurements. Finally, some guidelines for the use of both approaches and a summary of their advantages and disadvantages are presented.

Graphical abstract
Development of epimedin A complex drugs for treating the osteoporosis
Authors: Liu Ying , Bi Yanan , Chai Lijuan , Song Lei , Huang Juyang , Wang Qin , Li Yunzhang , Zhou Kun
Published: January 2021

Osteoporosis is the most common disease involving bone degeneration. As the age of the population increases, the prevalence of the disease is expected to rise. However, current treatment methods do not provide a desirable solution for the restoration of the function of degenerated bones in patients with osteoporosis. This led to emergence of controlled delivery systems to increase drug bioavailability and efficacy specifically at the bone regeneration. In this study, an epimedin A (EA) complex drug system was prepared by solution blending method. In vitro cell-based experiments showed that the EA complex drug could significantly promote the differentiation and proliferation of osteoblasts and increase the alkaline phosphatase activity, calcium nodule formation, and the expression of osteogenesis-related genes and proteins. In vivo experiments further demonstrated that this novel drugs remarkably enhanced bone regeneration. These results suggest that EA may be used for the treatment of osteoporosis.
Urbanization impacts on flood risks based on urban growth data and coupled flood models
Authors: Feng Boyu , Zhang Ying , Bourke Robin
Published: January 2021

Urbanization increases regional impervious surface area, which generally reduces hydrologic response time and therefore increases flood risk. The objective of this work is to investigate the sensitivities of urban flooding to urban land growth through simulation of flood flows under different urbanization conditions and during different flooding stages. A sub-watershed in Toronto, Canada, with urban land conversion was selected as a test site for this study. In order to investigate the effects of urbanization on changes in urban flood risk, land use maps from six different years (1966, 1971, 1976, 1981, 1986, and 2000) and of six simulated land use scenarios (0%, 20%, 40%, 60, 80%, and 100% impervious surface area percentages) were input into coupled hydrologic and hydraulic models. The results show that urbanization creates higher surface runoff and river discharge rates and shortened times to achieve the peak runoff and discharge. Areas influenced by flash flood and floodplain increases due to urbanization are related not only to overall impervious surface area percentage but also to the spatial distribution of impervious surface coverage. With similar average impervious surface area percentage, land use with spatial variation may aggravate flash flood conditions more intensely compared to spatially uniform land use distribution.
Projected explicit and implicit Taylor series methods for DAEs
Authors: Estévez Schwarz Diana , Lamour René
Published: January 2021

The recently developed new algorithm for computing consistent initial values and Taylor coefficients for DAEs using projector-based constrained optimization opens new possibilities to apply Taylor series integration methods. In this paper, we show how corresponding projected explicit and implicit Taylor series methods can be adapted to DAEs of arbitrary index. Owing to our formulation as a projected optimization problem constrained by the derivative array, no explicit description of the inherent dynamics is necessary, and various Taylor integration schemes can be defined in a general framework. In particular, we address higher-order Padé methods that stand out due to their stability. We further discuss several aspects of our prototype implemented in Python using Automatic Differentiation. The methods have been successfully tested on examples arising from multibody systems simulation and a higher-index DAE benchmark arising from servo-constraint problems.
Agency in historical institutionalism: Coalitional work in the creation, maintenance, and change of institutions
Authors: Emmenegger Patrick
Published: January 2021

Institutionalism gives priority to structure over agency. Yet institutions have never developed and operated without the intervention of interested groups. This paper develops a conceptual framework for the role of agency in historical institutionalism. Based on recent contributions following the coalitional turn and drawing on insights from sociological institutionalism, it argues that agency plays a key role in the creation and maintenance of social coalitions that stabilize but also challenge institutions. Without such agency, no coalition can be created, maintained, or changed. Similarly, without a supporting coalition, no contested institution can survive. Yet, due to collective action problems, such coalitional work is challenging. This coalitional perspective offers a robust role for agency in historical institutionalism, but it also explains why institutions remain stable despite agency. In addition, this paper forwards several portable propositions that allow for the identification of who is likely to develop agency and what these actors do.
Same same, but different: capital structures in single family offices compared with private equity firms
Authors: Schickinger Antonia , Bertschi-Michel Alexandra , Leitterstorf Max P. , Kammerlander Nadine
Published: January 2021

Despite the increasing interest in single family offices (SFOs) as an investment owned by an entrepreneurial family, research on SFOs is still in its infancy. In particular, little is known about the capital structures of SFOs or the roots of SFO heterogeneity regarding financial decisions. By drawing on a hand-collected sample of 104 SFOs and private equity (PE) firms, we compare the financing choices of these two investor types in the context of direct entrepreneurial investments (DEIs). Our data thereby provide empirical evidence that SFOs are less likely to raise debt than PE firms, suggesting that SFOs follow pecking-order theory. Regarding the heterogeneity of the financial decisions of SFOs, our data indicate that the relationship between SFOs and debt financing is reinforced by the idiosyncrasies of entrepreneurial families, such as higher levels of owner management and a higher firm age. Surprisingly, our data do not support a moderating effect for the emphasis placed on socioemotional wealth (SEW).
H2O coordination in macropa complexes of f elements (Ac, La, Lu): feasibility of the 11th coordination site
Authors: Kovács Attila , Varga Zoltán
Published: January 2021

The feasibility of an additional ligand coordination at the 11th coordination site of actinium, lanthanum, and lutetium ions in 10-fold coordinated macropa complexes has been studied by means of density functional theory calculations. The study covered the two main macropa conformers, Δ(δλδ)(δλδ) and Δ(λδλ)(λδλ), favoured by larger (Ac3+, La3+) and smaller (Lu3+) ions, respectively. At the molecular level, the coordination of H2O is the most favourable to the largest Ac3+while only slightly less to La3+. Protonation of the picoline arms enhances the coordination by shifting the metal ion closer to the open site of the ligand. The choice of macropa conformer has only a slight influence on the strength and bonding properties of the H2O coordination. Aqueous solution environment decreases considerably the energy gain of H2O coordination at the 11th coordination site.
Can happiness measures be calibrated?
Authors: Ingelström Mats , van der Deijl Willem
Published: January 2021

Measures of happiness are increasingly being used throughout the social sciences. While these measures have attracted numerous types of criticisms, a crucial aspect of these measures has been left largely unexplored—their calibration. Using Eran Tal’s recently developed notion of calibration we argue first that the prospect of continued calibration of happiness measures is crucial for the science of happiness, and second, that continued calibration of happiness measures faces a particular problem—The Two Unknowns Problem. The Two Unknowns Problem relies on the claim that individuals are necessarily a part of the measurement apparatus in first person measures of happiness, and the claim that we have no reason to believe that the evaluation standards people employ are invariant across individuals and time. We argue that calibrating happiness measures therefore involves solving an equation with two unknowns—an individual’s degree of happiness, and their evaluation standards—which is, generally, not possible. Third, we consider two possible escape routes from this problem and we suggest that the most promising route requires yet unexplored empirical and theoretical work on linking happiness to behavioral or neural evidence.
Financial Resilience, Income Dependence and Organisational Survival in UK Charities
Authors: Green Elizabeth , Ritchie Felix , Bradley Peter , Parry Glenn
Published: January 2021

The financial well-being of the charity sector has important social implications. Numerous studies have analysed whether the concentration of income in a few sources increases financial vulnerability. However, few studies have systematically considered whether the type of income (grants, donation, fund-raising activities) affects the survival prospects of the charity. We extend the literature by (a) explicitly modelling the composition of sources of income, (b) allowing for short-term volatility as well as long-term survival and (c) testing alternative specifications in a nested form. We show that the usual association between income concentration per se and financial vulnerability is a specification error. Greater vulnerability is associated with dependence on grant funding, not overall concentration. Previous studies showing that concentration of income per se is problematic are picking up a proxy effect. We also show that the volatility of income streams may be an important factor in the survival of charities, but that this also varies between income sources.
Informal Volunteering and Socialization Effects: Examining Modelling and Encouragement by Parents and Partner
Authors: Ramaekers Marlou J. M. , Verbakel Ellen , Kraaykamp Gerbert
Published: January 2021

Informal volunteering is seen as an important indicator of social relations and community life. We therefore investigate the impact of various socialization practices on informal volunteering, being small helping behaviours outside of organizations for people outside the household. From theoretical notions on socialization, we hypothesize that experiencing extensive prosocial socialization practices promotes informal volunteering. We examine socialization processes of both modelling and encouragement and consider two socializing agents: parents and partners. We test our expectations employing the sixth wave of the Family Survey Dutch Population (N = 2464) that included unique measures on socialization as well as informal volunteering and holds important control variables. Our results indicated that parental modelling, partner modelling and partner encouragement were all positively related to informal volunteering, but that parental encouragement was not significantly related to informal volunteering. Our paper, thus, underscores that socialization practices are relevant in nurturing social relations and community life.
Spectrum of [18F]FDG-PET/CT Findings in Benign Lymph Node Pathology
Authors: Zeman Merissa N. , Green Clare , Akin Esma A.
Published: January 2021

Diffuse lymphadenopathy has a long differential diagnosis that includes both malignant and benign causes. As part of the lymphadenopathy work-up, many patients undergo [18F]FDG-PET/CT for purposes of ruling out malignancy. FDG-avid lymph nodes, however, are not specific for malignancy. This review will illustrate the spectrum of nodal findings on FDG-PET/CT with correlation to other cross-sectional imaging and clinical history in patients with representative infectious, inflammatory, and benign lymphoproliferative disorders. These findings are important for the nuclear medicine radiologist to understand, as they can represent common pitfalls in the work-up of lymphadenopathy. While FDG-PET/CT may be limited in ascertaining a definitive diagnosis in a disease process as the cause of lymphadenopathy, it can help to narrow this differential and rule out certain diseases in the correct clinical context.