bluuebunny/crossref_metadata_2025 huggingface dataset:
Christian Fundamentalism and Support for Capital Punishment
Authors: Unnever James D. , Cullen Francis T.
Published: March 2006

Few public policy issues have inflamed passions as consistently and as strongly as the debate over capital punishment. Religious denominations have been deeply involved on both sides of the issue, drawing both on teachings and traditions of justice and on those that emphasize the dignity of human life. Scholarly researchers have investigated the role that religious beliefs play in shaping sentiments toward crime control policies, with a particular focus on the relationship between belonging to a Christian fundamentalist denomination and support for the death penalty. Researchers have reasoned that Christian fundamentalists should be more likely to support capital punishment than other more moderate denominations because they hold conservative religious beliefs that justify the use of the death penalty. Using 1998 data from the General Social Survey, the authors initially show that contrary to common views, Christian fundamentalist affiliation is unrelated to support for capital punishment. Subsequent analyses reveal, however, that this null relationship is not straightforward but complex: fundamentalists embrace certain religious beliefs and involvement that both increase and decrease punitiveness. The study thus suggests that understanding the impact of religion on crime control attitudes potentially requires disentangling countervailing effects of different features of religiosity.
The wisdom of experience: Autobiographical narratives across adulthood
Authors: GlüCk Judith , Bluck Susan , Baron Jacqueline , Mcadams Dan P.
Published: March 2006

This research uses an autobiographical approach to examine the relation of age to several aspects of wisdom. In Study 1 (N 1/4 86), adolescents', young adults', and older adults' wisdom narratives were content-coded for the types of life situations mentioned and the forms that wisdom took. Types of life situations reported (e.g., life decisions) were the same across age groups. Three different forms of wisdom emerged (empathy and support; self-determination and assertion; balance and flexibility) and their frequency differed with age. In Study 2, middle-aged and older adults' (N 1/4 51) autobiographical wisdom narratives were also analysed for type of situation and form of wisdom, but with the addition of two comparison life events: being foolish and having a very positive experience. Most findings replicated Study 1. Unlike Study 1, however, regardless of age, Study 2 participants largely showed the wisdom form, empathy and support. Results are discussed in terms of variations in individuals' implicit theories of wisdom as applied to their own lives.
Mainland Chinese parenting styles and parent–child interaction
Authors: Xu Yiyuan , Farver Jo Ann M. , Zhang Zengxiu , Zeng Qiang , Yu Lidong , Cai Beiying
Published: March 2006

Parenting styles and mother–child interaction were examined with 97 Mainland Chinese mothers (M age 1/4 29.64 years, SD 1/4 3.64) and their young children (M 1/4 24.30 months, SD 1/4 4.57). Mothers completed questionnaires about their parenting styles, orientation to Chinese cultural values, perceived parenting stress, and sources of social support. The regression analyses showed that mothers’ adherence to Chinese values was associated with both authoritative and authoritarian parenting styles. Other characteristics of the family contexts, such as perceived parenting distress, social support, and years of education, also contributed to Chinese mothers’ parenting styles. Mother–child dysfunctional interaction was associated with mothers’ heightened parenting distress, a lack of perceived social support, and perceptions of children's difficultness. Group comparisons revealed that Chinese mothers who had high scores for both authoritative and authoritarian parenting styles adhered most strongly to the Chinese cultural values. The findings suggest that the aspects of families’ eco-cultural settings such as mothers’ endorsement of Chinese cultural values and perceived parenting stress contribute to their parenting styles and interaction with their children.
Why do ethnic minority (Indian) children living in Britain display more internalizing problems than their English peers? The role of social support and parental style as mediators
Authors: Atzaba-Poria Naama , Pike Alison
Published: March 2006

The purpose of this paper was to examine explanatory mechanisms of differences in children's internalizing problems between ethnic minority (i.e., Indian) and ethnic majority (i.e., English) children living in Britain. Fifty-nine English children (31 girls) and 66 Indian children (30 girls), and their parents constituted the sample of this study. Both mothers and fathers reported on the children's internalizing problems, and provided reports of their own parenting style and social support. Analysis showed that maternal positivity, paternal negativity, and both parents’ reports of social support mediated the link between ethnicity and internalizing problems. Furthermore, according to the best-fitting structural equation model, ethnicity did not have a direct influence on children's internalizing problems, nor on parental style. Ethnicity instead predicted parental reports of social support. Social support, in turn, contributed to children's internalizing problems directly as well as indirectly through parenting style. Finally, although parenting style significantly influenced children's internalizing problems, social support was a much stronger contributor. The role of the distal as well as the proximal environments on children's adjustment is discussed.
Parenting styles and the development of the categorical self: A longitudinal study on mirror self-recognition in Cameroonian Nso and German families
Authors: Keller Heidi , Kärtner Joscha , Borke Joern , Yovsi Relindis , Kleis Astrid
Published: March 2006

This prospective study contributes to the understanding of the development of self-conceptions in cultural context. We examined the influence of maternal contingent responsiveness towards their 3-month-old infants on toddlers’ self-recognition at the age of 18 to 20 months. We contrasted two samples that can be expected to differ with respect to contingent responsiveness as a parenting style: German middle-class families and Cameroonian Nso farmers. As hypothesized, German mothers reacted more contingently than Nso mothers. Furthermore, German toddlers recognized themselves more often than Nso toddlers. Finally, we found that the level of contingent responsiveness was one of the mechanisms that accounted for mirror self-recognition. The results are discussed with respect to different cultural emphases on parenting strategies.
The accuracy of adult narrative reports of developmental trajectories
Authors: Cohen Patricia , Kasen Stephanie , Bifulco Antonia , Andrews Howard , Gordon Kathy
Published: March 2006

This methodological investigation examines the accuracy of narrative-based scaled ratings covering several post high school years. Guided narratives by young adults described developmentally relevant behaviour and context for each month between ages 17 and the mid-20s. “Prospective” narratives covered shorter time periods in three interviews separated by about 1 year each. A fourth “retrospective” interview included the entire period covered in the previous narratives and took place 1 year after the last prospective interview. Study variables were reliable ratings of data from these carefully conducted and blindly repeated narratives. Aspects of the study design expected to maximise reliability and validity of these data are provided. Prospective–retrospective (test–retest) correlation of ratings based on data from 149 participants covering an average of 64 studied months each on role-related, qualitative, and social variables are reported. The high consistency of many developmental variables based on these reports suggests that retrospective narratives can produce reliable and valid scaled measures covering a substantial period of time.
Middle-class African American families’ expectations for adolescents’ behavioural autonomy
Authors: Daddis Christopher , Smetana Judith
Published: March 2006

Timetables for adolescents’ behavioural autonomy were examined using a modified version of Feldman and Quatman’s (1988) teen timetable measure with 73 middle-class African American middle adolescents (M age 1 / 4 14.96 years, SD 1 / 4 1.29) and their parents (73 mothers and 44 fathers), who were followed longitudinally for 3 years. African American mothers’ and fathers’ expectations for adolescents’ behavioural autonomy did not differ, but expectations varied greatly across issues, and mothers consistently endorsed later timetables than did adolescents. Autonomy expectations each could be described in terms of two empirically derived, conceptually meaningful, and internally consistent composites pertaining to personal and prudential issues. They were earlier for personal than prudential issues and for prudential issues, for boys than for girls. Mothers’ (but not adolescents’) expectations for the desired timing of adolescents’ autonomy over personal and prudential issues predicted increased autonomy over those issues 3 years later.
Applicability of Baumrind's parent typology to collective cultures: Analysis of cultural explanations of parent socialization effects
Authors: Sorkhabi Nadia
Published: March 2006

This article reviews studies that have examined whether Baumrind's parenting styles are related to child outcomes similarly in cultures where independence is said to be emphasized versus cultures where interdependence is said to be emphasized. I present evidence showing that Baumrind's parenting styles have similar function in both collectivist and individualist cultures. Based on these studies, I argue against the claim of some researchers that authoritarian parenting is not detrimental or authoritative parenting beneficial to the development of young people in cultures that are said to emphasize interdependence. However, more research is needed before conclusions can be reached about the extent to which the culture construct explains child-rearing effects on child development. Future directions for research, which include the importance of identifying diverse forms of parenting within interdependent cultures so as to distinguish the influence of functional and dysfunctional forms of parenting on child outcomes, are suggested.
Five-year-olds can show the self-reference advantage
Authors: Sui Jie , Zhu Ying
Published: March 2006

The current study developed a new paradigm to determine the age at which children begin to show the self-reference advantage in memory. Four-, 5-, and 10-year-olds studied lists of colourful object pictures presented together with self or other face image, and participants were asked to report aloud “who is pointing at the (object).” Then incidental free recall was carried out, followed by source judgments based on the earlier test where participants had to distinguish who pointed to the object. In Experiment 1, only 5-year-old children showed self-reference advantage in the recall, but not in source judgments. By increasing task demand in Experiment 2, 5 and 10-year-olds also showed the self-reference advantage in the recall, but not in source judgments. These results indicated that the new paradigm is appropriate to measure children's self-reference effect in memory, and children as young as 5 years begin to show this effect.
ADHD symptoms and peer relations of children in a community sample: Examining associated problems, self-perceptions, and gender differences
Authors: Diamantopoulou Sofia , Henricsson Lisbeth , Rydell Ann-Margret
Published: March 2006

This study examined children's peer relations in relation to gender, symptoms of attention-deficit/ hyperactivity disorder (ADHD), associated behaviour problems, prosociality, and self-perceptions, in a community sample. Six hundred and thirty-five 12-year-old children (314 girls) provided peer nominations and rated feelings of loneliness and self-perceptions regarding global self-worth and behavioural conduct. We obtained teacher ratings of ADHD symptoms, conduct and internalising problems, and prosociality. ADHD symptoms, conduct problems, internalising problems, and low levels of prosociality were all related to higher levels of peer dislike. Despite ADHD symptoms being related to more peer dislike, children with high levels of ADHD symptoms did not report more feelings of loneliness. The self-perceptions of children with high levels of ADHD were not related to peer dislike. Although high levels of ADHD symptoms were not related to peer dislike in girls, peers tolerated higher levels of ADHD symptoms among boys than among girls, providing support for the “gender appropriateness hypothesis” regarding the impact and influence of ADHD symptomatology upon the peer relations of children within a community sample.
Coregulating distress: Mother–child interactions around children's distress from 14 to 24 months
Authors: Tonyan Holli A.
Published: March 2006

The current study complements existing research about emotion regulation by using a naturalistic, longitudinal design to (a) explore interpersonal dimensions of emotion regulation during unstructured mother–child interaction around distress and (b) explore how these interactions influence children's emerging emotion regulation from 14 to 24 months. Fifty Latino families were visited in their homes at both 14 and 24 months. Thirty minutes of unstructured interaction were videotaped and coded. Emotionally challenging episodes were identified based on ratings of the children's distress vocalisations. Within each episode, mothers' and children's behaviour were rated for interpersonal characteristics of their behaviour toward each other and the roles that each played in episode resolutions. On average, mother–child interaction was well coordinated across both ages. The degree to which children communicated about their distress clearly at 24 months was related to earlier maternal behaviour whereas the match between the intensity of children's emotion signals and the context was related to concurrent maternal behaviour (at both 14 and 24 months).
Authority and moral reasons: Parenting style and children's perceptions of adult rule justifications
Authors: Leman Patrick J.
Published: March 2006

The style of parenting of 100 children (mean age 11 years, 5 months) was established according to Baumrind's typology. Children were asked to indicate what they thought an adult would say to justify a moral rule in five different scenarios. Results indicated that parenting style did not relate to the number of justifications that children thought adults would produce but did affect the types of justifications they thought adults would give. Children of authoritative parents thought that adults would use more justifications based on reciprocity or equality in social relations than children of authoritarian parents. The results suggest that children of authoritative parents do not perceive adults to offer a more discursive moral atmosphere than children of other parents do; rather these children are more likely than others to think that adults will justify moral rules specifically in terms of equality in social relations. An unexpected finding was that children of permissive parents tended to judge that adults would legitimise judgments by pointing to the consequences of action for other people.
Attitudes of music teachers towards final examinations in the French music conservatoires
Authors: Maugars Cédricia
Published: March 2006

This research investigated the attitudes towards assessment of music teachers in Brittany, France. The relative significance attached to musical examination and the psychological attitudes of music teachers towards assessment were examined. Participants (staff, students, teachers and directors of five music conservatoires in Brittany) were interviewed and completed two Q-sort questionnaires in which 20 statements reflected attitudes towards music assessment. Results suggested that musical performances in French schools of music are organized in a final and normative form. This article demonstrates how two different epistemological concepts, ‘evaluation’ and ‘exam’, are seen as very similar in the opinions of music teachers.
Music as a cultural identity: a case study of Latino musicians negotiating tradition and innovation in northwest Ohio
Authors: O’Hagin Isabel Barbara , Harnish David
Published: March 2006

This study, based on recent field research, explores Latino music culture in Toledo, Ohio, and presents strategies for incorporating the music into the classroom. In the ethnographic project, three professors - music educator, ethnomusicologist, folklorist - interviewed many musicians, bands and community leaders. Musicians were regenerating Mexican-American traditions, especially that of the folk conjunto ensemble, while developing strategies to innovate the sound and meet the changing aesthetics of a populist youth market and emerging pan-Latino identity. In addition to reconstructing traditional culture, musicians and community leaders were interested in crafting a positive image for both cultural outsiders and insiders and reaching out to the greater Toledo community. The authors highlight the musical lives of the artists, suggest that musicians can play a role in shaping culturally sensitive class curricula, and advocate that educators and students engage directly in fieldwork projects to better grasp the meaning of music in peoples’ lives.
The development of an after-school music program for at-risk children: student musical preferences and pre-service teacher reflections
Authors: Ward-Steinman Patrice Madura
Published: March 2006

An urban university music education department and an outreach organization partnered to provide after-school music classes for at-risk children. Fourteen music education majors were recruited to teach 125 first through fifth graders (6-12 years of age), whose ethnicity was 55 percent Hispanic and 45 percent African-American. Classes included general music, recorder, and choir. Musical preference measures indicated significant differences among grades, except for two pieces that reflected the ethnicity of the students. Pre-service teachers were most successful at teaching moving, performing, and listening to a variety of music, and least successful at teaching composing and improvising; and they were able to achieve all of the stated goals for a successful urban youth program, especially being a positive force and musical mentor, and making the experience enjoyable, challenging, and extraordinary for the children.
Differential Expression of S100C in Thyroid Lesions
Authors: Torres-Cabala Carlos , Panizo-Santos Angel , Krutzsch Henry C. , Barazi Heba , Namba Masayoshi , Sakaguchi Masakiyo , Roberts David D. , Merino Maria J.
Published: March 2006

Identification of new potential markers that may help in the diagnosis of benign and malignant thyroid lesions is needed. By comparative 2-dimensional gel electrophoresis of microdissected cells from tumors and normal thyroid tissue, we identified a new protein, S100C, which is highly expressed in papillary carcinomas. In order to validate this finding, we investigated the immunohistochemical expression and the potential role in diagnosis of these markers in 94 specimens representing the spectrum of malignant and benign thyroid lesions. Normal thyroid tissue was evaluated in 57 specimens. Galectin-3, a marker reported as specific for malignant lesions, was also evaluated in the same lesions. S100C protein was expressed in the nuclei of normal tissue, hyperplastic nodules, and follicular adenomas and carcinomas. Papillary carcinomas showed a strong, but cytoplasmic, pattern of staining. Galectin-3 immunostaining was strongly positive in papillary carcinomas, and negative in benign lesions, confirming its value in differential diagnosis. These findings suggest that immunohistochemical staining of S100C could be helpful in the pathological study of thyroid lesions, especially in cases in which follicular variants of papillary carcinoma and follicular carcinoma are considered in the differential diagnosis.
Neuroendocrine Cells in Barrett’s Mucosa and Adenocarcinomas of the Gastroesophageal Junction
Authors: Koppert Linetta B. , Wijnhoven Bas P.L. , Tilanus Hugo W. , Stijnen Theo , van Dekken Herman , Dinjens Winand N. M.
Published: March 2006

We estimated the prevalence and prognostic significance of neuroendocrine (NE) cells in a series of 208 resection specimens containing gastroesophageal junction (GEJ) adenocarcinomas, with 56 specimens containing Barrett’s mucosa. Immunohistochemically, chromogranin A (CGA) was positive in 49% (102/208) of GEJ adenocarcinomas and in 68% (38/56) of Barrett’s mucosas. CGA in GEJ tumors correlated with pTNM stage. CGA in Barrett correlated with pTNM stage and tumor grade of the adjacent carcinoma. Patients with CGA in Barrett had better survival than patients without CGA in Barrett, with 5-year survival percentages of 56% and 9%, respectively. In multivariate analysis, CGA in Barrett was an independent prognostic factor for survival after surgery. Therefore CGA in Barrett adjacent to GEJ adenocarcinoma might be helpful in the assessment of patient outcome.
Clinical Implication of Dermatopathic Lymphadenopathy Among Japanese
Authors: Kojima Masaru , Nakamura Shigeo , Itoh Hideaki , Yamane Yuko , Shimizu Kazuhiko , Murayama Kayoko , Ohno Yoshihiro , Tanaka Hiroshi , Sugihara Shiro , Suzuki Yutaka , Shimano Shunichi , Masawa Nobuhide
Published: March 2006

To clarify the clinicopathologic and immunohistochemical features of dermatopathic lymphadenopathy not associated with mycosis fungoides among Japanese, 19 patients were studied. Seventy-four percent of the patients were more than 50 years old (median; 63 years, mean 61 years). Systemic symptoms such as fever were recorded in 68% and multicentric lymphadenopathy was noted in 83% of patients. An association of autoimmune disease or positivity of autoantibodies was recorded in 6 patients. Five patients showed cutaneous hypersensitivity reactions to a drug. Histologically, in addition to the dermatopathic lymphadenopathy, numerous immunoblasts were observed in 2 cases and sheet-like proliferation of mature plasma cells in 3 cases. Various atypical or malignant lymphoproliferative disorders exhibiting immunologic abnormalities such as angioimmunoblastic T-cell lymphoma or autoimmune disease-associated lymphadenopathy frequently occur in middle-aged and elderly patients. At least some of the patients with dermatopathic lymphadenopathy should be clinicopathologically differentiated from these lymphoproliferative disorders.
Alveolar Adenoma of the Lung: A Clinicopathologic, Immunohistochemical, and Molecular Study of an Unusual Case
Authors: Cavazza Alberto , Paci Massimiliano , De Marco Loredana , Leporati Guido , Sartori Giuliana , Bigiani Nazzarena , Rossi Giulio
Published: March 2006

We describe an alveolar adenoma of the lung with 3 previously unreported findings, which expand both the clinical and the morphologic spectrum of this rare tumor: presentation as a cystic nodule, foci of mature adipocytes, and S-100 positivity of the mesenchymal cells. Furthermore, using a laser capture microdissection technique under microscope visualization, we analyzed multiple chromosomal loci in both the epithelial and mesenchymal components of the lesion, showing microsatellite alterations and loss of heterozygosity in the former but not in the latter.
Pleomorphic Rhabdomyosarcoma of the Anterior Abdominal Wall Following Multimodality Treatment for Carcinoma of the Rectum
Authors: Rajaram Veena , Hill D. Ashley , Doherty Gerard M. , Liapis Helen , Dehner Louis P.
Published: March 2006

Postradiation sarcomas are rare, and the most commonly reported ones are malignant fibrous histiocytoma, osteosarcoma, angiosarcoma, fibrosarcoma, malignant peripheral nerve sheath tumor, and high-grade pleomorphic sarcoma, not otherwise specified. There are a few case reports of postradiation rhabdomyosarcomas following treatment of retinoblastoma, breast cancer, endometrial adenocarcinoma, and Hodgkin’s disease. Secondary neoplasms following radiation and surgical treatment of rectal adenocarcinomas have not been reported in the English literature. We report a case of pleomorphic rhabdomyosarcoma of the anterior abdominal wall following treatment of rectal carcinoma, and we review the literature.
Collecting Duct Carcinoma Exhibiting Diastase-Resistant PAS-Positive Globular Cytoplasmic Inclusions and Rhabdoid Features Arising in Adult Polycystic Kidney Disease: A Case Report
Authors: Kuroda Naoto , Satake Hirofumi , Miyazaki Eriko , Hayashi Yoshihiro , Hiroi Makoto , Enzan Hideaki
Published: March 2006

A 76-year-old man complained of lumbago, and a subsequent detailed examination revealed a mass in the left kidney. Macroscopically, multiple cysts were recognized in the bilateral kidney; the tumor proliferated predominantly in the renal medulla and showed a whitish color with focal necrosis and hemorrhage. A histologic examination of the surgically resected tumor showed various growth patterns, such as solid, tubular, and papillary, by tumor cells. The diagnosis of collecting duct carcinoma (CDC) was made. Furthermore, tumor cells contained globular inclusions resembling hyaline globules and large eosinophilic inclusions, resulting in rhabdoid features, in the cytoplasm. Histochemically, globular inclusions were positive for periodic acid-Schiff (PAS) with diastase pretreatment. Immunohistochemically, large esosinophilic inclusions were reactive for vimentin. Although these findings are rare in CDCs, they should be recognized in the pathologic spectrum of CDCs.
Subcellular Localization of Immunohistochemical Signals
Authors: Cheuk W. , Chan John K. C.
Published: March 2006

In the literature, sufficient attention has not been paid to the precise subcellular localization of immunohistochemical signals, the knowledge of which is essential for proper interpretation of immunostains and distinction of genuine staining from biotin-associated or other nonspecific stainings. The subcellular localization of the signals can in fact be easily deduced from the known biologic or ultrastructural characteristics of the antigens. Extracellular antigens obviously are located in the extracellular compartment. Cellular antigens fall into 3 major groups: membranous, nuclear, and cytoplasmic. Membranous antigens include cell adhesion molecules (such as E-cadherin, N-CAM), cell surface/transmembrane receptors and proteins (such as tyrosine kinase receptors, most leukocyte antigens, CD10, CEA), and molecules linking surface molecules to cytoskeleton (such as β-catenin, dystrophin). Nuclear antigens include cell cycle-associated proteins (such as cyclins, p16, Ki-67), nuclear enzymes (such as TdT), transcription factors (such as TTF-1, CDX-2, myogenin, PAX-5), tumor suppressor gene products (such as p53, p63, WT1, Rb), steroid hormone receptors (such as ER, PR), calcium-binding proteins (such as S-100 protein, calretinin), and some viral proteins (such as CMV, herpes). Cytoplasmic antigens can take up a granular pattern due to localization in organelles, granules, or secretory vesicles (such as chromogranin, hormones, lysozyme, HMB-45), fibrillary pattern attributable to the filamentous nature of the molecules (intermediate filaments and microfilaments), or diffuse or patchy pattern due to localization in the cytosol or large vesicles (such as myoglobin, albumin, thyroglobulin). Aberrant localization of the molecules, when present, can provide important insight into disease processes and aid in their diagnosis, such as loss of membranous E-cadherin expression in lobular breast carcinoma, aberrant nuclear localization of β-catenin in colorectal adenocarcinoma, pattern of ALK staining in anaplastic large cell lymphoma correlating with the different types of chromosomal translocations, presence of additional cytoplasmic CD10 staining in the enterocytes indicative of microvillous inclusion disease, and “reversed” staining for EMA in micropapillary mammary carcinoma.
Liver-Cell Adenomas with Heavy Iron Deposition
Authors: Abdulkader I. , Suárez-Peñaranda J. M. , Pérez-Becerra E. , Baltar J. , Pazos G. , Forteza J.
Published: March 2006

We report 3 unusual cases of liver cell adenomas with some uncommon features, corresponding to 3 women aged 45, 37, and 41 years, respectively. The diagnosis was incidental in 2 cases, and the third presented with abdominal pain. Radiologic findings were consistent with liver-cell adenoma, but gross examination failed to reveal the lesion until 24 hours of formalin fixation in 2 cases. Histopathological examination showed a striking deposition of iron pigment. In fact, Pearl’s stain was the best way to visualize the limits of the neoplasm, which were irregular (pseudo-infiltrative). There was no evidence of other architectural or cytologic features suggesting an alternative diagnosis, particularly liver-cell carcinoma. Follow-up ranged from 9 months to 6 years and all patients are free of disease.
Extraarticular Synovial Chondromatosis: Review of Epidemiology, Imaging Studies, Microscopy and Pathogenesis, with a Report of an Additional Case in a Child
Authors: Ko Emily , Mortimer Errol , Fraire Armando E.
Published: March 2006

A rare benign condition of uncertain etiology and pathogenesis, Synovial Chondromatosis (SC) is most often seen intraarticularly in adults but only a handful of cases have been reported extraarticularly in children. Symptoms and physical signs consist of pain, swelling, and osteoarthritic changes related to a mass effect. Here we discuss the case of a 9-year-old boy with documented SC of the knee and critically review the Epidemiology, Clinical Presentation, Gross Anatomy and Microscopic Histopathologic Features as well as the role of Imaging Studies in Diagnosis. In addition, this paper reviews Current Pathogenetic Concepts including the infrequent but distinct possibility of malignant transformation.
Prostatic Duct Carcinoma with Combined Prostatic Duct Adenocarcinoma and Urothelial Carcinoma Features
Authors: Pacchioni D. , Casetta G. , Piovano M. , Fraire F. , Volante M. , Sapino A. , Tizzani A. , Bussolati G.
Published: March 2006

We report a unique case of prostatic duct carcinoma (PDC) featuring both prostatic duct adenocarcinoma (PDA) and high-grade urothelial carcinoma (HG-UC). An 84-year-old man presenting with hematuria showed at ultrasonography and cystoscopy a papillary neoplasia located near to the verumontanum. Histopathologic examination of specimens from transurethral resection revealed a tumor originating from large prostatic ducts showing 2 different components: PDA with endometrioid features (main pattern) and HG-UC (minor part). Immunohistochemically, the areas of PDA were positive for prostatic acid phosphatase (PAP), prostatic specific antigen (PSA), and androgen receptors (AR), while negative for estrogen (ER) and progesterone receptors (PGR). Prognostic factors evaluation pointed out a low proliferation index (10%) and focal expression of p53 (6%); c-erb-B2 was not overexpressed. The HG-UC areas were negative for all previous markers, while positive for thromobomodulin. The proliferation index was high (60%), and p53 was diffusely expressed (55%). The incidence and significance of PDC with combined features is discussed with reference to literature data.
Correlation of Epidermal Growth Factor Receptor Expression with Tumor Microdensity Vessels and with Vascular Endothelial Growth Factor Expression in Ovarian Carcinoma
Authors: Raspollini Maria Rosaria , Castiglione Francesca , Garbini Francesca , Villanucci Alessandro , Amunni Gianni , Baroni Gianna , Boddi Vieri , Taddei Gian Luigi
Published: March 2006

We analyzed in advanced ovarian serous G3 carcinoma the correlation between epidermal growth factor receptor (EGFR) overexpression and tumor angiogenesis and their relation with clinical outcome. Microvessel density (MVD) and vascular endothelial growth factor (VEGF) were statistically correlated with disease-free interval and death from disease both in univariate and multivariate analyses while EGFR expression was not correlated with clinical outcome. MVD was significantly associated with progression of disease during chemotherapy while VEGF and EGFR expression were not correlated with responsiveness to chemotherapy (Fisher’s exact test). VEGF expression was correlated with MVD (Fisher’s exact test). EGFR showed a trend to correlation with MVD. Further studies focusing on the use of angiogenesis inhibitors in addition to EGFR inhibitors on ovarian carcinoma cells may produce therapeutic strategies in the selection of tailored therapies in ovarian cancer patients.
The 2004 WHO Classification of Bladder Tumors: A Summary and Commentary
Authors: Montironi Rodolfo , Lopez-Beltran Antonio
Published: March 2006

The key points of the latest World Health Organization (WHO) classification of noninvasive urothelial tumors are the following: the description of the categories has been expanded to improve their recognition; a tumor with particularly good prognosis (papillary urothelial neoplasm of low malignant potential) no longer carries the label of ‘cancer’; it avoids the use of ambiguous grading such as grade 1/2 or 2/3 (as done in the 1973 WHO classification); the group of noninvasive high-grade carcinoma is large enough to virtually contain all those tumors having biological properties similar to those seen in invasive urothelial carcinoma, and a similarly high level of genetic instability. This scheme is meant to replace the 1973 WHO classification, but the use of both the 1973 and the latest WHO classifications is recommended until the latter is sufficiently validated.
Histopathological Study of Small (<2 cm) Gastric Carcinoma with Signet-Ring Cell Component: Significance of the Admixed Glandular Components
Authors: Ohkura Yasuo , Kawamata Hitoshi , Chibana Yoko , Ichikawa Kazuhito , Fujii Sigehiko , Tomita Sigeru , Ono Yuko , Fujimori T.
Published: March 2006

Admixture of signet-ring cell carcinoma component (SIG) and glandular component (GC) is sometimes found in a gastric cancer. The aim of this study was to elucidate the biological behavior of the gastric cancer containing either SIG only (SIG-type tumor) or SIG admixed with GC (SIG-GC-type tumor). Forty-three cases of SIG-type tumor and 26 cases of SIG-GC-type tumor, less than 2 cm in largest diameter, were examined. Twenty-six cases (60%) of SIGs were less than 10 mm in size, whereas only 3 cases (12%) of SIG-GCs were less than 10 mm in size (p<0.0001). Submucosal invasion by cancer cells was found in 12 cases of SIG-GCs but was not found in any of the SIGs. Those SIG-GCs showed gastric phenotype. It is important to note SIGGC-type tumor for histopathological diagnosis.
Irinotecan-induced Colitis
Authors: Sandmeier D. , Chaubert P. , Bouzourene H.
Published: March 2006

Irinotecan (CPT-11) is a chemotherapeutic drug used to treat tumors by acting on malignant cells through inhibition of DNA topoisomerase I and inducing premature apoptosis. Major toxic effects of Irinotecan are myelosuppression and gastrointestinal (GI) toxicity, which limits the dose of administration, particularly severe diarrhea with a delay of onset. However, according to the literature, serious GI side effects are uncommon, comprising 3% of the reported cases. The mechanism of Irinotecan-induced delayed diarrhea is unknown and unpredictable. To our knowledge, this is the first case of colitis associated with Irinotecan administration for temporal glioblastoma documented by biopsies. The histopathologic findings are described and the potential mechanisms inducing such lesions are discussed.
Congenital Juvenile Granulosa Cell Tumor of the Testis in a Fetus Showing Full 69, XXY Triploidy
Authors: Kos Marina , Nogales Fernandez Francisco , Kos Milan , Stipoljev Feodora , Kunjko Kristian
Published: March 2006

Testicular juvenile granulosa cell tumor (TJGCT) occurs predominantly in infancy and may be associated with sex chromosomal abnormalities. We report a fetus aborted because of cytogenetically confirmed complete XXY triploidy. External genitalia of the fetus were female, with a short and patent vagina. The tumor presented as an abdominal multicystic mass with typical histologic and immunohistological features of JGCT. It was connected with a tubular uterus-like structure. The other gonad was an inguinally localized testis that showed histologically a Sertoli cell adenoma. Malformations typical for triploidy were also present: agenesis of the corpus callosum, stenosis of the pulmonary ostium, and hypoplasia of the lungs and adrenals. To our knowledge this is the first case of TJGCT in a triploid fetus.
Cutaneous Melanoma Metastatic to Uterine Adenomyoma: Report of a Case
Authors: Di Tommaso Luca , Rahal Daoud , Bresciani Gianluigi , Roncalli Massimo
Published: March 2006

Rare cases of metastasis to uterine polyps have been reported in English literature but not, to the best of our knowledge, to uterine adenomyomas. All these cases are represented by breast cancer, most of them involving tamoxifen-associated polyps. We first report a case of cutaneous malignant melanoma metastatic to uterine adenomyoma. A computed tomography scan did not reveal any further evidence of disease, suggesting that this metastatic localization may represent something more than a fortuitous case. Based on these observations it is suggested that a subset of malignant melanoma and breast cancer cells share a sort of “homing” phenomenon to polypoid lesions of uterus, due probably to the presence of some chemokines and their specific receptors. Pathologists should be aware of this possibility in order to look carefully for metastatic implants in similar lesions. It is proposed that chemokine profile of neoplastic cells can be a useful tool in predicting metastatic targets.
Pathologic Features of Necrotizing Adenoviral Prostatitis in an AIDS Patient
Authors: Dikov Dorian , Chatelet François P. , Dimitrakov Jordan
Published: March 2006

Adenovirus has been implicated as a cause of opportunistic infections in immunocompromised patients, frequently with multiorgan involvement and a fatal outcome. We describe a case of necrotizing adenoviral prostatitis in a 35-year-old man with terminal AIDS and generalized adenoviral infection. The histopathologic findings of intraacinar necrotizing inflammation, prominent viral nuclear inclusions in residual epithelium, and mild T-lymphocyte and macrophageal inflammatory reaction were observed in the prostate. The presence of adenovirus was confirmed by electron microscopy and immunohistochemistry. Squamous metaplasia was present in the surrounding acini. This case of adenoviral prostatitis appears to be the first report of its kind in medical literature and demonstrates another aspect of the diversity of organ manifestations seen in this infection. This lesion should be included in the differential diagnosis of necrotizing prostatic diseases.
Rosai-Dorfman Disease: Successful Long-term Results by Combination Chemotherapy with Prednisone, 6-Mercaptopurine, Methotrexate, and Vinblastine: A Case Report
Authors: Jabali Y. , Smrcka V. , Pradna J.
Published: March 2006

Sinus histiocytosis with massive lymphadenopathy (SHML), also known as Rosai-Dorfman disease (RDD), is a rare clinicopathologic entity of unknown etiology. The majority of patients do not require treatment, demonstrating spontaneous resolution or stable disease. However, in some cases the disorder runs a progressive course and/or threatens vital structures and functions, which dictates some form of intervention. It is not clear what constitutes the best approach for those cases. We report on a girl with an extensive and progressive form of the disease who was cured with combination chemotherapy, showing no evidence of recurrence after a follow-up of 5.5 years.
Granular Cell Tumor of the Thyroid: A Case Report
Authors: Baloch Zubair W. , Martin Susan , LiVolsi Virginia A.
Published: March 2006

We report a rare case of granular cell tumor (GCT) arising within the thyroid parenchyma. The differential diagnosis of GCT in thyroid includes all oncocytic/Hürthle cell lesions of the thyroid, medullary carcinoma and metastasis. The classic histomorphologic features and immunohistochemistry are helpful in arriving at the correct diagnosis.
Mediastinal Germ Cell Tumor Associated with Histiocytic Sarcoma of Spleen: Case Report of an Unusual Association
Authors: Song Sang Yong , Ko Young Hyeh , Ahn Geunghwan
Published: March 2006

We present an unusual association of mediastinal germ cell tumor containing seminoma and angiosarcoma components and splenic histiocytic sarcoma. A 15-year-old boy presented with chest pain. Histopathologically, an anterior mediastinal mass contained typical seminoma, immature teratoma, embryonal carcinoma, angiosarcoma, yolk sac tumor, and polyembryoma. An abdominal ultrasonogram revealed a huge splenomegaly with multiple ill-defined low echogenic nodules, 1 month after the second cycle of chemotherapy. Histopathologically, large, round-to-oval tumor cells with abundant eosinophilic cytoplasm often contained eccentrically placed nuclei with vesicular chromatin and an irregular nuclear membrane. The tumor cells were immunoreactive for CD68, CD31, and CD4. The cytogenetic results showed deletion of the long arm of chromosome 5 and trisomy 8. This lesion might have been on the pathway of multistep tumorigenesis toward a final leukemia.
Primary Angiolipoma of the Thyroid Gland: A Case Report
Authors: Palazzo Juan P. , Coté Sean A.
Published: March 2006

We report a case of an angiolipoma involving the thyroid gland of a 74-year-old woman. The patient presented with a multinodular goiter that was surgically removed. Gross examination of the specimen revealed an intrathyroidal well-circumscribed nodule that microscopically showed the typical features of an angiolipoma. There was no evidence of extrathyroidal extension, necrosis, or atypia. To our knowledge, this is the first reported case of a primary angiolipoma of the thyroid gland.
Clear Cell Sarcoma-like Tumor with Osteoclast-like Giant Cells in the Small Bowel: Further Evidence for a New Tumor Entity
Authors: Friedrichs Nicolaus , Testi Maria Adele , Moiraghi Luisa , Modena Piergiorgio , Paggen Ellen , Plötner Andreas , Wiechmann Volker , Mantovani-Löffler Luisa , Merkelbach-Bruse Sabine , Buettner Reinhard , Wardelmann Eva
Published: March 2006

Most mesenchymal neoplasms of the gastrointestinal tract belong to the category of gastrointestinal stromal tumors (GISTs) and are characterized by the immunohistochemical expression of KIT receptor. In cases without detectable KIT receptor expression several differential diagnoses have to be taken into consideration. Here, we report a case of a 41-year-old man with a tumor of the small bowel composed of large epithelioid tumor cells arranged in solid and alveolar sheets including scattered osteoclast-like multinucleated giant cells. Immunohistochemically, the tumor cells expressed strongly S-100 protein, vimentin, and to a lesser extent, bcl-2. HMB-45, melan-A, KIT receptor, desmin, smooth-muscle actin, and CD-34 were not detectable. Ki-67 index was 20%. The diagnosis was established by 2 different FISH strategies demostrating the presence of a t(12;22)(q13;q12) translocation, the diagnostic hallmark of clear cell sarcoma of soft parts. Our results provide further evidence for the existence of a new tumor entity designated gastrointestinal clear cell sarcoma with osteoclast-like giant cells. The diagnosis of this entity should be considered in the presence of S-100-positive tumors of the gastrointestinal tract containing multinucleated giant cells and can be established by FISH analysis.
Biomarker Analysis in Carcinoma ex Pleomorphic Adenoma at an Early Phase of Carcinomatous Transformation
Authors: Freitas Leandro L.L. , Araújo Vera C. , Martins Marilia T. , Chone Carlos , Crespo Agricio , Altemani Albina
Published: March 2006

Diagnostic criteria for intracapsular carcinoma ex pleomorphic adenoma (CXPA) are subjective and vary among authors. Biomarker analysis, which could provide more objective evaluation of these tumors, has rarely been studied in intracapsular CXPA. Immunohistochemical evaluation of c-erbB-2, p53 protein, bcl-2, and Ki-67 was performed in 8 cases of CXPA at an early phase of malignant transformation (4 intracapsular and 4 minimally invasive) and in 17 pleomorphic adenomas (PA). In all cases of CXPA, p53 and Ki-67 were demonstrated predominantly in luminal cells of benign and malignant areas, significantly more in the latter. Few benign myoepithelial cells were p53 positive. c-erbB-2 reactivity was strongly associated with atypical luminal cells. Bcl-2 expression was weak and focal in malignant areas from 2 cases. In conclusion, both p53 and c-erbB-2 proteins appear to be involved at an early stage of malignization of PA. In PA with atypical cells, evaluation of the expression of these 2 markers provides more objective criteria for the diagnosis of intracapsular CXPA.
Role of Chromogenic in Situ Hybridization (CISH™) in the Evaluation of HER2 Status in Breast Carcinoma: Comparison with Immunohistochemistry and Fish
Authors: Li-Ning-T Elsa , Ronchetti Ruben , Torres-Cabala Carlos , Merino Maria J.
Published: March 2006

We report our experience with Chromogenic in Situ Hybridization (CISH™) for the evaluation of HER2 amplification on 55 cases of formalin-fixed, paraffin-embedded invasive breast carcinomas of different histology. All the results were corrected for chromosome 17 aneusomy and compared with immunohistochemistry (IHC); a subset of cases was compared to FISH. Thirty-one of 32 cases in which FISH and CISH™ were performed yielded the same results. CISH™ and IHC showed a good concordance in the 0/1+ and 3+ category, while a poor agreement with weakly protein overexpression was confirmed. Chromosome 17 analysis was necessary in cases with a low number of HER2 gene copies. CISH™ is a useful tool to evaluate breast cancer HER2 status that can be easily implemented in a laboratory of surgical pathology.
Antigen Retrieval Methods and Estrogen Receptor Immunoexpression Using 1D5 Antibody: A Comparative Study
Authors: Neves J. I. , Begnami M. D. , Arias V. , Santos G. C.
Published: March 2006

Long-term formalin tissue fixation results in antigen masking, probably through aldehydic linkage between proteins and fixative molecules. Immunohistochemistry results depend on the type of the detection procedure and the type of antibody used for the reaction. Considering the difficulty in working with estrogen receptor (ER) antibodies and the lack of standardization of the antigen retrieval methods, we quantified the immunoexpression of ER using the 1D5 antibody and a standard streptavidin-biotin detection procedure retrieving with microwave oven, steamer, pressure cooker, and water bath in a set of SBR grade 2 invasive breast carcinomas. Pressure-cooking provided the best results. No significant differences were observed in using the other methods. Pressure-cooking should be recommended as the method of choice for standardization of the ER immunohistochemical reaction.
Peribiliary Cysts Can Mimic Caroli’s Disease: A Case Report
Authors: Fusai G. , Tucker O. , Sulaiman N. M. Nik , Karani J. , Rela M. , Portmann B.
Published: March 2006

Peribiliary cysts, otherwise known as cystic dilatation of the peribiliary glands, are uncommon, and are usually discovered incidentally at autopsy, or in explants following liver transplantation. Preoperative diagnosis is often difficult owing to their asymptomatic nature and small size. Exclusion of a premalignant or malignant cystic condition is mandatory. We report a case of peribiliary cysts, initially thought to represent Caroli’s disease, and briefly discuss the management of this condition.