bluuebunny/crossref_metadata_2025 huggingface dataset:
Geometric Structure of the Set of Pairs of Matrices under Simultaneous Similarity
Authors: GARCİA-PLANAS Maria İsabel
Published: December 2021

In this paper pairs of matrices under similarity are considered because of their scientific applications, especially pairs of matrices being simultaneously diagonalizable. For example, a problem in quantum mechanics is the position and momentum operators, because they do not have a shared base representing the system's states. They do not commute, and that is why switching operators form a crucial element in quantum physics. A study of the set of linear operators consisting of pairs of simultaneously diagonalizable matrices is done using geometric constructions such as the principal bundles. The main goal of this work is to construct connections that allow us to establish a relationship between the local geometry around a point with the local geometry around another point. The connections give us a way to help distinguish bundle sections along tangent vectors.
Sudden bilateral foot drop due to dorsally unilateral migration of the herniated lumbar disc: A case report
Authors: Seok Hoon , Lee Seung Yeol , Shin Dong Seong , Kang Jung Hoon , Im Soo Bin , Jeong Je Hoon
Published: December 2021

BACKGROUND: Due to the anatomical characteristics of the anterior epidural space, dorsal migration of material from herniated lumbar disc is quite rare. Also, bilateral foot drop due to unilateral dorsal migration of disc herniation is extremely rare. This report presents a case of sudden bilateral foot drop caused by the unilateral dorsal migration of material from a herniated lumbar disc. CASE DESCRIPTION: A 51-year-old male presented with sudden onset severe leg pain with bilateral foot drop. The patient was referred to our emergency department by a local clinic. Neurological examination showed bilateral ankle and big toe dorsiflexion weakness grade 1. There was no perianal anesthesia, anal sphincter weaknesses, or voiding difficulty. Apart from essential hypertension, this patient’s medical history was unremarkable. Magnetic resonance imaging showed that intervertebral disc material in the dorsal extradural space at the L3-4 level had compressed the dural sac from the left side to the center. We performed an emergency operation. The pathologic result revealed fibrous cartilaginous materials. After the operation, the leg pain was markedly resolved. At postoperative three months, the patient showed improvement of foot drop. CONCLUSION: We recommended emergent mass removal, which produced a favorable outcome.
Epithelial-mesenchymal transition interaction with CD8+ T cell, dendritic cell and immune checkpoints in the development of melanoma
Authors: Liang Tuo , Chen Jiarui , Xu Guoyong , Zhang Zide , Xue Jiang , Zeng Haopeng , Jiang Jie , Chen Tianyou , Qin Zhaojie , Li Hao , Ye Zhen , Nie Yunfeng , Liu Chong , Zhan Xinli
Published: December 2021

BACKGROUND: Melanoma is fatal cancer originating from melanocytes, whose high metastatic potential leads to an extremely poor prognosis. OBJECTIVE: This study aimed to reveal the relationship among EMT, TIICs, and immune checkpoints in melanoma. METHODS: Gene expression data and clinical data of melanoma were downloaded from TCGA, UCSC Xena and GEO databases. EMT-related DEGs were detected for risk score calculation. “ESTIMATE” and “xCell” were used for estimating TIICs and obtaining 64 immune cell subtypes, respectively. Moreover, we evaluated the relationship between the risk score and immune cell subtypes and immune checkpoints. RESULTS: Seven EMT-related genes were selected to establish a risk scoring system because of their integrated prognostic relevance. The results of GSEA revealed that most of the gene sets focused on immune-related pathways in the low-risk score group. The risk score was significantly correlated with the xCell score of some TIICs, which significantly affected the prognosis of melanoma. Patients with a low-risk score may be associated with a better response to ICI therapy. CONCLUSION: The individualized risk score could effectively conduct risk stratification, overall survival prediction, ICI therapy prediction, and TME judgment for patients with melanoma, which would be conducive to patients’ precise treatment.
TMEM130 regulates cell migration through DNA methylation in nasopharyngeal carcinoma
Authors: Liu Hong , Zhang Yong , Chen Wenqiang , Zhang Yan , Zhang Wen
Published: December 2021

BACKGROUND: Nasopharyngeal carcinoma (NPC), the common malignant head and neck cancer, is highly prevalent in southern China. The molecular mechanism underlying NPC tumorigenesis is unclear. We used 5-Aza-CdR, a DNA methyltransferase inhibitor, to treat NPC cell lines and discovered that the expression of TMEM130 changed significantly compared with the untreatment cells. This study aimed to identify the relationship between the DNA methylation status of TMEM130 and NPC, and to explore the function of TMEM130 in NPC cell migration. METHODS: qRT-PCR was performed to investigate the transcriptional expression of TMEM130 in NPC. Bisulfite sequencing PCR and 5-Aza-CdR treatment were used to detect the methylation level of the TMEM130 promoter. Gene Expression Omnibus (GEO) datasets were obtained to identifiy the methylation status and mRNA expression of TMEM130 in NPC and normal control tissues. Transwell and western blot analyses were used to detect cell migration ability after transfection of TMEM130/NC plasmids in NPC cells. RESULTS: The transcriptional expression of TMEM130 was decreased in NPC cell lines compared with in the NP69 cell line. TMEM130 promoter was significantly hyper methylated in three NPC cell lines (C666, CNE, and HONE) but hypo methylated in NP69 cells. The methylation level was higher in NPC than normal control tissues. Additionally, treatment of NPC cells with 5-Aza-CdR increased the TMEM130 mRNA expression level. Overexpression of TMEM130 in NPC cell lines suppressed cell migration ability and affected some epithelial-mesenchymal transition-associated gene expression. CONCLUSIONS: This study is the first to investigate the expression and function of TMEM130 in NPC. It was found that TMEM130 hyper methylation might contribute to NPC migration and this gene might act as a tumor suppressor gene. TMEM130 is a promising biomarker for NPC diagnosis.
Multiscale modeling of tumor response to vascular endothelial growth factor (VEGF) inhibitor
Authors: Hendrata Melisa , Sudiono Janti
Published: December 2021

Vascular endothelial growth factor (VEGF) has been known as a key mediator of angiogenesis in cancer. Bevacizumab is anti-VEGF monoclonal antibody that has been approved by the FDA as a first-line treatment in many types of cancer. In this paper, we extend a previously validated multiscale tumor model to comprehensively include the multiple roles of VEGF during the course of angiogenesis and its binding mechanism with bevacizumab. We use the model to simulate tumor system response under various bevacizumab concentrations, both in stand-alone treatment and in combination with chemotherapy. Our simulation indicates that periodic administration of bevacizumab with lower concentration can achieve greater efficacy than a single treatment with higher concentration. The simulation of the combined therapy also shows that the continuous administration of bevacizumab during the maintenance phase can lead to antitumor activity which further suppresses its growth. Agreement with experimental results indicates the potential of the model in predicting the efficacy of anti-VEGF therapies and could therefore contribute to developing prospective clinical trials.
Role of annular pentameric molecule: C-Reactive protein in periodontal disease and its association with systemic health
Authors: Kale Preeti Prakash , Mani Amit , Anarthe Raju , Mustilwar Rachita
Published: December 2021

Various acute phase reactants are produced in response to inflammatory stimuli, one of them is C-reactive protein. Serum levels of C-Reactive protein are useful to monitor and diagnose inflammatory process associated with disease as it being one of the valuable biomarkers in various clinical conditions, increase in level of C-Reactive protein is found in subjects with periodontal disease, which in turn can act as useful biomarker to diagnose cardiovascular disease, adverse pregnancy outcome as they being associated with periodontal disease. This manuscript is brief overview of C-Reactive protein and its relation with periodontal disease and systemic health.
Sedimentological and Grain Size Characteristics of Two Lake Cores from Himachal Pradesh, India
Authors: Kholia Neha , Kotlia Bahadur Singh , Porinchu David , Bisht Kamini , Sharma Anupam , Jalal Poonam
Published: December 2021

Two lake cores from Khajjiar (length 746 cm) and Rewalsar lakes (length 647 cm) in Himachal Pradesh (India) were retrieved to understand the sedimentological characteristics and variation in grain size distribution. Both the lake cores are Upper Holocene in age. The Rewalsar lake sediments are composed predominantly of silt with small amounts of clay, whereas the Khajjiar sediments contain sand, silt and clay and both cores have high carbonaceous matter. The standard deviation ranges from 0.88 ϕ to 2.56 ϕ for Khajjiar lake and from 0.957 ϕ to 2.264 ϕ for Rewalsar lake, indicating poorly to very poorly sorted core sediments. The values of the Kurtosis vary between 0.678 ϕ and 1.205 ϕ for Khajjiar lake and from 0.8 ϕ to 1.2.4 ϕ for Rewalsar lake, viewing platykurtic to leptokurtic nature. Further, the skewness value ranges from -0.097 ϕ to 0.240 ϕ for Khajjiar lake and 0.079 ϕ to 0.25 ϕ for Rewalsar lake revealing fine to symmetrical skewness model. The bivariate plots by using the grain-size parameters were also interpreted. The Total Organic Carbon (TOC) is higher in the Khajjiar lake sediments (0.9 to 31.2%; av. 10.6%), compared to that in the Rewalsar lake sediments (1.0 to 9.0; av. 2.6%). The sedimentological characteristics indicate that the energy conditions were linked to the climatic conditions prevailing in the area. In general, the Khajjiar lake core is composed of relatively coarser sediments and more affected by arid conditions while the fine fraction of the Rewalsar shows the consequence of lower energy conditions. The Khajjiar lake shows the transition from fluctuating conditions (zone 1) to humid (zone 2) to arid (zone 3), while the Rewalsar shows the change from fluctuating (zone 1) to humid conditions (zones 2 and 3). The similarity between zone 1 and 2 of both the lake profiles shows that both lakes have experienced similar climatic conditions during the deposition, revealing domination of fluctuating and arid conditions.
High Altitude Lake and Hydrochemistry: A Study of Lam Dal and Six Consecutive Lakes of Dhauladhar, Himachal Himalaya, India
Authors: Riju  , Singh Harminder Pal , Linda Anurag
Published: December 2021

Increased human influence has warmed the atmosphere, ocean and land thereby resulting in widespread and rapid changes in the atmosphere, ocean, cryosphere and biosphere (IPCC, 2021). High altitude lakes are generally small and quite sensitive to natural and anthropogenic perturbations. The present work is a preliminary work to investigate different hydro chemical processes and factors that controls the geochemistry of a high altitude lake, Lam Lake (dal) and its consecutive six lakes flowing through the Chamba district, Himachal Pradesh. Two hundred and eighty (n=280) water samples were collected in the year 2017 during the pre-monsoon and post-monsoon season. The anion concentration for all the seven lakes followed the trend HCO3- > NO3- > Cl- > SO42- > PO43- whereas the order of cation concentrations was Ca2+> Mg2+> Na+> K+ for both the seasons. Less EC of the water samples shows its serene nature. Components of bicarbonate (HCO3-) were found to be the major anion whereas calcium (Ca2+) was found to be the major cation present in the lakes. Piper Plot and Durov plot indicated Ca2+ – HCO3- as the major hydrogeochemical facies with comparatively less contribution from Mg2+–HCO3- type. The dominance of Ca2+ – HCO3- over Mg2+– HCO3- reflects the possibility of the natural order of dominance in the geology of the catchment area. The low Na+ + K+/TZ+ (total cations) ratios and the high Ca2+ + Mg2+/TZ+ (total cations) and (Ca2+ + Mg2+)/(Na+ + K+) ratios showed dominance of carbonate weathering. The average carbon ratios during pre-monsoon and post-monsoon were found to be 0.97 and 0.98, respectively, suggesting that proton is primarily derived from the oxidation of sulphide involving carbonate dissolution. The baseline data generated for a high-altitude lake shows that weathering and erosion during monsoonal precipitation and snow melt runoff during ablation season are the main sources of the chemical composition of lake water. Further to trace the imprints of climate change and seasonal variations in the high-altitude lakes, long term monitoring is recommended along with isotopic tracer techniques.
Color multi-focus image fusion based on transfer learning
Authors: Wang Yun , Jin Xin , Yang Jie , Jiang Qian , Tang Yue , Wang Puming , Lee Shin-Jye
Published: December 2021

Multi-focus image fusion is a technique that integrates the focused areas in a pair or set of source images with the same scene into a fully focused image. Inspired by transfer learning, this paper proposes a novel color multi-focus image fusion method based on deep learning. First, color multi-focus source images are fed into VGG-19 network, and the parameters of convolutional layer of the VGG-19 network are then migrated to a neural network containing multilayer convolutional layers and multilayer skip-connection structures for feature extraction. Second, the initial decision maps are generated using the reconstructed feature maps of a deconvolution module. Third, the initial decision maps are refined and processed to obtain the second decision maps, and then the source images are fused to obtain the initial fused images based on the second decision maps. Finally, the final fused image is produced by comparing the QABF metrics of the initial fused images. The experimental results show that the proposed method can effectively improve the segmentation performance of the focused and unfocused areas in the source images, and the generated fused images are superior in both subjective and objective metrics compared with most contrast methods.
Soft Rough Set based span for unsupervised keyword extraction
Authors: Chatterjee Niladri , Roy Aayush Singha , Yadav Nidhika
Published: December 2021

The present work proposes an application of Soft Rough Set and its span for unsupervised keyword extraction. In recent times Soft Rough Sets are being applied in various domains, though none of its applications are in the area of keyword extraction. On the other hand, the concept of Rough Set based span has been developed for improved efficiency in the domain of extractive text summarization. In this work we amalgamate these two techniques, called Soft Rough Set based Span (SRS), to provide an effective solution for keyword extraction from texts. The universe for Soft Rough Set is taken to be a collection of words from the input texts. SRS provides an ideal platform for identifying the set of keywords from the input text which cannot always be defined clearly and unambiguously. The proposed technique uses greedy algorithm for computing spanning sets. The experimental results suggest that extraction of keywords using the proposed scheme gives consistent results across different domains. Also, it has been found to be more efficient in comparison with several existing unsupervised techniques.
Searching for memory-lighter architectures for OCR-augmented image captioning
Authors: Gallardo-García Rafael , Beltrán-Martínez Beatriz , Hernández-Gracidas Carlos , Vilariño-Ayala Darnes
Published: December 2021

Current State-of-the-Art image captioning systems that can read and integrate read text into the generated descriptions need high processing power and memory usage, which limits the sustainability and usability of the models (as they require expensive and very specialized hardware). The present work introduces two alternative versions (L-M4C and L-CNMT) of top architectures (on the TextCaps challenge), which were mainly adapted to achieve near-State-of-The-Art performance while being memory-lighter when compared to the original architectures, this is mainly achieved by using distilled or smaller pre-trained models on the text-and-OCR embedding modules. On the one hand, a distilled version of BERT was used in order to reduce the size of the text-embedding module (the distilled model has 59% fewer parameters), on the other hand, the OCR context processor on both architectures was replaced by Global Vectors (GloVe), instead of using FastText pre-trained vectors, this can reduce the memory used by the OCR-embedding module up to a 94% . Two of the three models presented in this work surpassed the baseline (M4C-Captioner) of the challenge on the evaluation and test sets, also, our best lighter architecture reached a CIDEr score of 88.24 on the test set, which is 7.25 points above the baseline model.
A unified deep neuro-fuzzy approach for COVID-19 twitter sentiment classification
Authors: Bahuguna Aman , Yadav Deepak , Senapati Apurbalal , Saha Baidya Nath
Published: December 2021

Covid-19 braces serious mental health crisis across the world. Since a vast majority of the population exploit social media platforms such as twitter to exchange information, rapid collecting and analyzing social media data to understand personal well-being and subsequently adopting adequate measures could avoid severe socio-economic damage. Sentiment analysis on twitter data is very useful to understand and identify the mental health issues. In this research, we proposed a unified deep neuro-fuzzy approach for Covid-19 twitter sentiment classification. Fuzzy logic has been a very powerful tool for twitter data analysis where approximate semantic and syntactic analysis is more relevant because correcting spelling and grammar in tweets are merely obnoxious. We conducted the experiment on three challenging COVID-19 twitter sentiment datasets. Experimental results demonstrate that fuzzy Sugeno integral based ensembled classifiers succeed over individual base classifiers.
Fake News detection using n-grams for PAN@CLEF competition
Authors: Damian Sergio , Calvo Hiram , Gelbukh Alexander
Published: December 2021

The paper presents a classifier for fake news spreaders detection in social media. Detecting fake news spreaders is an important task because this kind of disinformation aims to change the reader’s opinion about a relevant topic for the society. This work presents a classifier that can compete with the ones that are found in the state-of-the-art. In addition, this work applies Explainable Artificial Intelligence (XIA) methods in order to understand the corpora used and how the model estimates results. The work focuses on the corpora developed by members of the PAN@CLEF 2020 competition. The score obtained surpasses the state-of-the-art with a mean accuracy score of 0.7825. The solution uses XIA methods for the feature selection process, since they present more stability to the selection than most of traditional feature selection methods. Also, this work concludes that the detection done by the solution approach is generally based on the topic of the text.
Electro-impedance mammograms for automatic breast cancer screening: First insights on Mexican patients
Authors: Romero-Coripuna Rosario Lissiet , Hernández-Farías Delia Irazú , Murillo-Ortiz Blanca , Córdova-Fraga Teodoro
Published: December 2021

Breast cancer is a very important health concern around the world. Early detection of such a disease increases the chances of survival. Among the available screening tools, there is the Electro-Impedance Mammography (EIM), which is a novel and less invasive method that captures the potential difference stored in breast tissues under the assumption that electrical properties among normal and pathologically altered tissues are different. In this paper, we address breast cancer detection as a multi-class problem aiming to determine the corresponding label in terms of the Breast Imaging Electrical Impedance classification system, the standard used by physicians for interpreting an EIM mammogram. For experimental purposes, for the first time in the literature, we took advantage of a dataset comprising EIM of Mexican patients. Aiming to establish a baseline for this task, traditional supervised learning methods were used together with two different feature extraction techniques: raw pixel data and transfer learning. Besides, data augmentation was exploited for compensating data imbalance. Different experimental settings were evaluated reaching classification rates over 0.85 in F-score. KNN emerges as a very promising classifier for addressing this task. The obtained results allow us to validate the usefulness of traditional methods for classifying electro-impedance mammograms.
Stride Velocity 95th Centile: Insights into Gaining Regulatory Qualification of the First Wearable-Derived Digital Endpoint for use in Duchenne Muscular Dystrophy Trials
Authors: Servais Laurent , Yen Karl , Guridi Maitea , Lukawy Jacek , Vissière David , Strijbos Paul
Published: December 2021

In 2019, stride velocity 95th centile (SV95C) became the first wearable-derived digital clinical outcome assessment (COA) qualified by the European Medicines Agency (EMA) for use as a secondary endpoint in trials for Duchenne muscular dystrophy. SV95C was approved via the EMA’s qualification pathway for novel methodologies for medicine development, which is a voluntary procedure for assessing the regulatory acceptability of innovative methods used in pharmaceutical research and development. SV95C is an objective, real-world digital ambulation measure of peak performance, representing the speed of the fastest strides taken by the wearer over a recording period of 180 hours. SV95C is correlated with traditional clinic-based assessments of motor function and has greater sensitivity to clinical change over 6 months than other wearable-derived stride variables, for example, median stride length or velocity. SV95C overcomes many limitations of episodic, clinic-based motor function testing, allowing the assessment of ambulation ability between clinic visits and under free-living conditions. Here we highlight considerations and challenges in developing SV95C using evidence generated by a high-performance wearable sensor. We also provide a commentary of the device’s technical capabilities, which were a determining factor in the regulatory approval of SV95C. This article aims to provide insights into the methods employed, and the challenges faced, during the regulatory approval process for researchers developing new digital tools for patients with diseases that affect motor function.
Effects of Cannabis in Parkinson’s Disease: A Systematic Review and Meta-Analysis
Authors: Urbi Berzenn , Corbett Joel , Hughes Ian , Owusu Maame Amma , Thorning Sarah , Broadley Simon A. , Sabet Arman , Heshmat Saman
Published: December 2021

The legalization of cannabis in many countries has allowed many Parkinson’s disease (PD) patients to turn to cannabis as a treatment. As such there is a growing interest from the PD community to be properly guided by evidence regarding potential treatment benefits of cannabis. This systematic review and meta-analysis aims to compile the best available evidence to help guide patients and their family, clinicians and researchers make informed decisions. A systematic search of the literature was conducted in June 2021. Five randomized controlled studies and eighteen non-randomized studies investigated cannabis treatment in PD patients. No compelling evidence was found to recommend the use of cannabis in PD patients. However, a potential benefit was identified with respect to alleviation of PD related tremor, anxiety, pain, improvement of sleep quality and quality of life. Given the relative paucity of well-designed randomized studies, there is an identified need for further investigation, particularly in these areas.
Evaluation and comparison of a CdTe based photon counting detector with an energy integrating detector for X-ray phase sensitive imaging of breast cancer
Authors: Ghani Muhammad U. , Omoumi Farid H. , Wu Xizeng , Fajardo Laurie L. , Zheng Bin , Liu Hong
Published: December 2021

PURPOSE: To compare imaging performance of a cadmium telluride (CdTe) based photon counting detector (PCD) with a CMOS based energy integrating detector (EID) for potential phase sensitive imaging of breast cancer. METHODS: A high energy inline phase sensitive imaging prototype consisting of a microfocus X-ray source with geometric magnification of 2 was employed. The pixel pitch of the PCD was 55μm, while 50μm for EID. The spatial resolution was quantitatively and qualitatively assessed through modulation transfer function (MTF) and bar pattern images. The edge enhancement visibility was assessed by measuring edge enhancement index (EEI) using the acrylic edge acquired images. A contrast detail (CD) phantom was utilized to compare detectability of simulated tumors, while an American College of Radiology (ACR) accredited phantom for mammography was used to compare detection of simulated calcification clusters. A custom-built phantom was employed to compare detection of fibrous structures. The PCD images were acquired at equal, and 30% less mean glandular dose (MGD) levels as of EID images. Observer studies along with contrast to noise ratio (CNR) and signal to noise ratio (SNR) analyses were performed for comparison of two detection systems. RESULTS: MTF curves and bar pattern images revealed an improvement of about 40% in the cutoff resolution with the PCD. The excellent spatial resolution offered by PCD system complemented superior detection of the diffraction fringes at boundaries of the acrylic edge and resulted in an EEI value of 3.64 as compared to 1.44 produced with EID image. At equal MGD levels (standard dose), observer studies along with CNR and SNR analyses revealed a substantial improvement of PCD acquired images in detection of simulated tumors, calcification clusters, and fibrous structures. At 30% less MGD, PCD images preserved image quality to yield equivalent (slightly better) detection as compared to the standard dose EID images. CONCLUSION: CdTe-based PCDs are technically feasible to image breast abnormalities (low/high contrast structures) at low radiation dose levels using the high energy inline phase sensitive imaging technique.
Acute respiratory infections and flu during the COVID-19 pandemic. What to expect in 2021–2022?
Authors:   Central Research Institute of Epidemiology of the Russian Federal Service for Supervision of Consumer Rights Protection and Human Well-Being, Moscow, Russian Federation, Usenko D.V. , Tkhakushinova N.Kh. ,   Kuban State Medical University, Krasnodar, Russian Federation,   Specialized Clinical Children’s Infectious Hospital, Krasnodar, Russian Federation, Shaturina T.T. ,   Kuban State Medical University, Krasnodar, Russian Federation,   Specialized Clinical Children’s Infectious Hospital, Krasnodar, Russian Federation, Ledenko L.A. ,   Kuban State Medical University, Krasnodar, Russian Federation,   Specialized Clinical Children’s Infectious Hospital, Krasnodar, Russian Federation, Bevzenko O.V. ,   Kuban State Medical University, Krasnodar, Russian Federation,   Specialized Clinical Children’s Infectious Hospital, Krasnodar, Russian Federation
Published: December 2021

This paper discusses the spread of the most common causative agents for respiratory viral infections, i.e., respiratory syncytial virus (RSV) and influenza virus (IV), during seasonal peaks and under the COVID-19 pandemic. The COVID-19 pandemic and epidemic control measures reduced the transmission of some respiratory viral pathogens. The authors specify the risks of changes in RSV epidemiology associated with restrictions and their lifting. Possible scenarios of virus "behavior" in 2021–2022 are represented. These scenarios include the return of variants registered at the end of 2019 and the risk of the emergence of a novel strain of zoonotic flu that may result in a novel viral pandemic. It was demonstrated that effective monitoring of causative agent circulation, timely specific prophylaxis (particularly in high-risk groups), and early effective antiviral therapy are crucial irrespective of the possible scenario of respiratory viral infection. Modern principles of complex flu and acute respiratory viral infection treatment using an antiviral agent based on rimantadine and sodium alginate are addressed. KEYWORDS: flu, COVID-19, pandemic, respiratory syncytial infection, children, treatment, rimantadine, sodium alginate. FOR CITATION: Usenko D.V., Tkhakushinova N.Kh., Shaturina T.T. et al. Acute respiratory infections and flu during the COVID-19 pandemic. What to expect in 2021–2022? Russian Medical Inquiry. 2021;5(11):721–727 (in Russ.). DOI: 10.32364/2587-6821-2021- 5-11-721-727.
COVID-19 vaccination of pregnant women: state-of-the-art
Authors:   Khanty-Mansi State Medical Academy, Khanty-Mansiysk, Russian Federation, Girina A.A. , Zaplatnikov A.L. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Svintsitskaya V.I. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation, Izhogina S.D. ,   Russian Medical Academy of Continuous Professional Education, Moscow, Russian Federation
Published: December 2021

Despite efforts made by the world community to battle the novel coronavirus infection, we are still unable to take complete control of virus spread. One of the causes of this issue is inadequate coverage of vaccination. Meanwhile, disease course in specific populations is associated with the risks of severe complications and lethal outcome. Infection of pregnant women is of particular concern. This paper addresses recent data on vaccination against the COVID-19 infection in pregnant women, including those with risk of severe disease course and unfavorable outcome. Monitoring the health of women infected with SARS-CoV-2 during gestation demonstrates unfavorable effects of the COVID-19 infection on the course and outcome of pregnancy. On the other hand, observational programs have demonstrated that vaccination has no effects on pregnancy course and perinatal outcomes. A view of the WHO and professional associations on the vaccination of pregnant women, particularly those from risk groups of severe COVID-19 course, is discussed. The importance of a personalized and balanced approach to COVID-19 vaccination of pregnant women involving the assessment of risks and benefits for the mother and child is emphasized. KEYWORDS: novel coronavirus infection, COVID-19, vaccination, immunization, pregnant women, risk group. FOR CITATION: Girina A.A., Zaplatnikov A.L., Svintsitskaya V.I., Izhogina S.D. COVID-19 vaccination of pregnant women: state-of-the-art. Russian Medical Inquiry. 2021;5(11):768–772 (in Russ.). DOI: 10.32364/2587-6821-2021-5-11-768-772.
Virtual Multidisciplinary Tumor Boards: A Narrative Review Focused on Lung Cancer
Authors: Guarini Aurelia Ada
Published: December 2021

To date, the virtual multidisciplinary tumor boards (vMTBs) are increasingly used to achieve high-quality treatment recommendations across health-care regions, which expands and develops the local MTB team to a regional or national expert network. This review describes the process of lung cancer-specific MTBs andthe transition process from face-to-face tumor boards to virtual ones. The review also focuses on the project organization’s description, advantages, and disadvantages. Semi-structured interviews identified five major themes for MTBs: current practice, attitudes, enablers, barriers,
and benefits for the MTB. MTB teams exhibited positive responses to modeled data
feedback. Virtualization reduces time spent for travel, allowing easier and timely patient discussions. This process requires a secure web platform to assure the respect of patients’ privacy and presents the same unanswered problems. The implementation of vMTB also permits the implementation of networks especially in areas with geographical barriers facilitating interaction between large referral cancer centers and tertiary or community hospitals as well as easier access to clinical trial opportunities.
Studies aimed to improve preparations, structure, and conduct of MTBs, research methods to monitor their performance, teamwork, and outcomes are also outlined in this article. Analysis of literature shows that MTB participants discuss 5–8 cases per meeting and that the use of a vMTB for lung cancer and in particular stage III NSCLC and complex stage IV cases is widely accepted by most health professionals. Despite still-existing gaps, overall vMTB represents a unique opportunity to optimize patient management in a patientcentered approach.
Culturology: conceptual and categorical framework in the research process logic
Authors: Sabadash Julia , Dablo Liubov , Nikolchenko Josef
Published: December 2021

The purpose of the article is to analyze the conditions and stages in the formation of the conceptual-categorical framework of cultural sciences. The methodology is based on general scientific approaches such as terminological and systematic. The purpose and objectives of the publication define the use of such research methods as analysis, synthesis, generalization, which made it possible to clarify the meaning of a number of concepts and terms. Scientific Novelty. The degree of scientific research of the topic is concentrated in identifying the problems of interaction between the conceptual and categorical frameworks in various scientific fields, namely, history, philosophy, philology, aesthetics, ethics, art history, and logic, to shape up the research space. We conceptualize the idea of "formal logical structures": that is not a mechanical combination of concepts or categories, but developing a new system adapted to solving theoretical problems of cultural studies. The question about the validity of the ―borrowing‖ process that allows cultural studies to analyze theoretical problems related to other humanitarian fields is also touched upon. Conclusion. So, among the other Ukrainian human sciences, cultural studies are developing quite actively and dynamically, constantly expanding its research space; its activity and dynamism of the cultural knowledge ―accumulation‖ determine those problems requiring special attention of modern scientists; in particular, the identification of the structural layering of the conceptual and categorical framework of cultural sciences.
Integration of virtual and augmented reality into art
Authors: Volynets Viktoriia
Published: December 2021

The purpose of the article is to explore the transformation of artistic practices under the influence of virtual and augmented reality. The methodology is based on the application of the dialectical method, which allows to reveal the specifics of virtual / augmented / mixed realities through the prism of the dialectic of interaction between technology and man. The scientific novelty of the results is the analysis of the essence of the transformation of artistic practices under the influence of virtual and augmented reality, in particular, introduced into scientific circulation data on art projects using innovative technologies of augmented and mixed reality as a clear example of integration of the latter into art. Transboundary is considered from two points of view - the convergence of art and its reconstruction. It is stated that the implementation of projects using AR and VR technology is currently impossible without the appropriate logistics and computer technology skills. The indirectness of translation and perception of cultural experience by digital devices that determine a new technological format of personality inculturation is considered. Conclusions. These changes affect all spheres of society, erasing the spatio-temporal boundaries and involving people in an interactive creative process. Art responds most dynamically and reflects all changes in society, and modern cultural institutions are forced to take into account these trends and on this basis to form strategies for development and interaction with various stakeholders based on the use of virtual (VR), augmented (AR) reality. The difference between virtual art and other forms of art using computer technology is that its basis is not representation, but communication. Thus, numerous creative projects, implemented with the help of augmented and mixed reality, demonstrate the active use of technology in art, in the process of creating a movie, virtual exhibitions, etc.
National kitchen as a component of the gastronomic culture of the ethnos: Essence and methods of research
Authors: Krasovskyi Serhii
Published: December 2021

The purpose of the article is to propose methods for researching national cuisine as a gastronomic ethnic coder. Methodology. In the proposed article, the national cuisine is considered through the prism of the analytical method, which makes it possible to use the authentic method of studying and identifying the multifaceted forms of its representation. The scientific novelty of the study is to consider the national cuisine as a gastronomic code of the ethnic group, that is, an ordered image of food consumption due to the habitat, cultural and historical development and religious component. The article also first proposed as a methodological basis for the study of national cuisine phenomenological, structural methods and the interpretation method, the cumulative use of which will contribute to building the original concept of studying a wide range of national cuisine issues. Conclusions. In the conclusions, it is noted that the expansion of modern gastronomic practices of people, an increase in public catering enterprises, the popularity of gastronomic tourism, the desire to join the exotic with tastes determine the expansion of research interest in the field of gastronomic culture and its component - national cuisine. Attention is drawn to problems that require learning, including the detection of the gastronomic code of the ethnos, the disclosure of the national cuisine, and also suggest the opportunity to interpret the history and culture of the people through the prism of food. The most appropriate methods of studying the gastronomic code are proposed: the phenomenological, structural and interpretation method, the use of which in the aggregate will contribute to the identification of an ordered image of the universe of the ethnos, disclosure through the practice of the unknown pages of the history of culture, interpretation of the connection of dishes with weight lifestyle and the characteristics of culture, with the help of recipes to identify features of nutrition, priority dishes and their ingredients, cooking technology.
Aesthetic values as an object of research: from an Aesthetic to Cultural studies’ generalization
Authors: Lyashenko Lydia
Published: December 2021

The purpose of the article is to prove the expediency and scientific, methodological, conceptual, and categorical potential of Cultural studies as a science that may offer an updated perspective for the study of the problem of aesthetic values. Methodology. Methods of scientific analysis, comparison, and generalization during the elaboration of the source base and the method of systematization are used to determine the traditional and innovative directions of research of the problem of aesthetic values. Scientific novelty. The article considers the interdisciplinary and generalizing potential of Cultural studies on the example of the problem of study aesthetic values. The existing tendency to move the analysis of problems of humanities from separate sciences to the plane of interdisciplinary is emphasized. It was accented on the novelty and relevance of such interdisciplinary research within Cultural studies. Conclusions. The approach of Cultural studies offers an increase in the scale of generalization from aesthetic to actually global, which combines the experience of studying scientific problems in the traditional and extended areas. Given the fact that on the one hand, all material and spiritual values which surround man were born from culture, because culture is the cumulative result of productive human activity, and, on the other hand, culture absorbs them, being phenomenon generalized, interdisciplinary approach of Cultural studies is able to suggest an updated perspective on this problem on the border of traditional and non-traditional sciences and through the improvement of its conceptual and categorical apparatus to offer new ways to study.
The cultural potential of Modest Mentsinsky's work in the context of the development of the musical culture of the early twentieth century
Authors: Turchak Lesia
Published: December 2021

The purpose of the article is to establish the contribution of the opera singer and famous tenor Modest Omelianovych Mentsynskyi to Ukrainian and world music art. The methodology is based on using historical, biographical, and analytical methods, which allows distinguishing and reviewing the special features of the Ukrainian singer‘s ―internationally universal‖ performance style as well as tracking the stages of his creative evolution. The scientific novelty of the research is in the affirmation that the artist‘s work within the mentioned period, on the one hand, led to the ―Europeanization‖ of the Ukrainian music culture, which influenced the formation of the national vocal and opera school, and, on the other hand, his high vocal level and popularization of the Ukrainian music in the walls of numerous European theaters promoted the popularization of the Ukrainian music culture in the world. Conclusions. Relying on the achievements of the three most famous opera schools (Italian, German and French) and his own experience, the signer formed the ―internationally universal‖ performance style, which helped him make a considerable contribution to the development of opera art in at least three countries: Germany (as the most prominent singer of Wagner‘s plays with a vocal role of a ―heroic tenor‖), Sweden (as a performer and pedagogue who stood at the origins of the vocal school in this country) and Ukraine (as a talented interpreter of the Ukrainian chamber repertoire and popularizer of the national music heritage in the world).
Producer in the culture of audiovisual production
Authors: Lavreniuk Sergii
Published: December 2021

The purpose of the article is to determine the features of functioning and motivation of the film producer in the culture of audiovisual production and to outline scientific vectors that will serve as a comprehensive analysis of the phenomenon of production in the intercultural space. Methodology. In elaborating the topic, a theoretical method was used to typify the functional features of the producer's activity; analytical method and methods of scientific analysis, comparison, generalization, which were useful in the process of establishing the creative and production features of the film producer in the culture of the audiovisual field. For the sake of art history and culturological aspects of studying the problem, methods of systematization and analysis were used. The scientific novelty of the study is that the problem of functioning and motivation of the producer in the context of the culture of audiovisual production has become the subject of a special comprehensive study; the content of the concept of "audiovisual creativity" as a certain specific integrity and unity of interconnected elements is argued and clarified; the expediency of using the comparative method for the study and manifestation of the peculiarities of producer's creativity in the film production process is proved. Conclusions. Acquaintance with the materials of this study, enriches the vast knowledge of the specifics of the producer in the culture of audiovisual production and provides a scientific basis for their use in courses on the theory and history of culture, including filmmaking, production and directing.
Representations of queer identity in David Lynch's film Mulholland Drive
Authors: Molodina Alena
Published: December 2021

The purpose of the article. This essay considers the queer identity as a modern tragic figure through a reading of David Lynch's 2001 film Mulholland Drive. Methodology. The article uses a comprehensive interdisciplinary approach using the methodological tools of cultural studies and queer theory based on structural-functional, semiotic-hermeneutic analysis, as well as Lacan's psychoanalytic concept of the subject. The scientific novelty. Within the framework of the humanities, in particular cultural studies, the analysis of the film by David Lynch "Mulholland Drive" in the context of queer theory is carried out for the first time. Conclusions. Since cinematography is a synthesis of various types of art, it embodies cultural phenomena and reproduces realities of life. Analysis of the peculiarities of the representation of queer identity in David Lynch's film Mulholland Drive through the prism of queer theory, in which identity is nothing more than a phenomenon that forms under the pressure of the dominant discourse and social order gives it the status of a cultural illusion or myth, demonstrates existing ideals. Cinema in the context of queer theory is self-reflective, autocratic, not indifferent. It can create a safe space - and at the same time be a protest action. The means by which the representation of a queer identity takes the place can be traced at all symbolic levels (material, index, iconic). At the material level, the grand plan is used as a sign in which all the characters in the film are related, without separating homosexual women visually. At the level of index status, the creation of the image of a homosexual couple is due to their profession. The heroines belong to the creative environment, in their relationship the dominant role is played by Diane. At the iconic level, images are constructed through their relationship with society. The heroines experience internal contradictions between their psychological state, natural nature, and social norms. The sexuality that is represented in the film contains a confrontation between the individual and the social. There is a tendency to normalize the image of queer identity in cinema, due to changes in the public consciousness. Based on the analysis, it was found that the film David Lynch reflects homosexuality as such, and not in the canonical models of traditional relationships.