bluuebunny/crossref_metadata_2025 huggingface dataset:
Über die Verknüpfung von (Medien-) Innovationsforschung und Netzwerkanalyse mittels theoretischer Konzeptualisierung und empirischer Fundierung
Authors: Schulz Iren
Published: March 2020

Rezension zu Thilo von Pape Aneignung neuer Kommunikationstechnologien in sozialen Netzwerken. Am Beispiel des Mobiltelefons unter Jugendlichen. Wiesbaden: VS Verlag für Sozialwissenschaften, 2008. 305 Seiten ISBN 978-3-531-16133-4
Rezension zu Thillosen (2008): Schreiben im Netz
Authors: Panke Stefanie
Published: March 2020

Rezension zu Anne Thillosen Schreiben im Netz. Neue literale Praktiken im Kontext Hochschule. Münster: Waxmann, 2008. 348 Seiten ISBN 978-3-8309-2061-8
Kleine Mädchenwelten statt große Weltmädchen
Authors: Reißmann Wolfgang
Published: March 2020

Rezension zu Doris Katheder Mädchenbilder in deutschen Jugendzeitschriften der Gegenwart Beiträge zur Medienpädagogik Wiesbaden: VS, 2008. 347 Seiten ISBN: 978-3-531-15940-9
Medienbildung als Umgang mit gesellschaftlicher Kontingenz in und mithilfe von Medien
Authors: Hugger Kai-Uwe , Cwielong Ilona Andrea
Published: March 2020

Rezension zu Benjamin Jörissen und Winfried Marotzki Medienbildung – Eine Einführung Stuttgart: UTB, 2009. 260 Seiten ISBN-13: 978-3825231897
Grundlagen einer facettenreichen Disziplin
Authors: Schiefner Mandy , Reißmann Wolfgang
Published: March 2020

Rezension zu Uwe Sander, Friederike von Gross, Kai-Uwe Hugger (Hrsg.) Handbuch Medienpädagogik Wiesbaden: VS Verlag, 2008. 602 Seiten ISBN-13: 978-3531150161
Rezension zu Hesmondhalgh & Toynbee (2008): The Media and Social Theory
Authors: Maharajh Divya
Published: March 2020

Rezension zu: Hesmondhalgh, David, und Jason Toynbee, Hrsg. 2008. The media and social theory. Culture, Economy and the Social. New York: Routledge.
Annäherungen an das Phänomen Computerspiel
Authors: Autenrieth Kelvin
Published: March 2020

Rezension zu: Swertz, Christian, und Michael Wagner, Hrsg. 2010. Game\\Play\\Society: contributions to contemporary computer game studies. Wiener Medienpädagogik. München: kopaed.
Seniorenwelten sind Fernsehwelten
Authors: Kamin Anna-Maria
Published: March 2020

Rezension zu: Doh, Michael. 2011. Heterogenität der Mediennutzung im Alter: theoretische Konzepte und empirische Befunde. Gesellschaft-Altern-Medien, Bd. 2. München: Kopaed.
Aufwachsen im Medienzeitalter
Authors: Klimsa Anja
Published: March 2020

Rezension zu: Moser, Heinz. 2010. Einführung in die Medienpädagogik: Aufwachsen im Medienzeitalter. 5., durchges. und erw. Aufl. Lehrbuch. Wiesbaden: VS Verlag für Sozialwissenschaften.
Vom spielerischen Charakter des interaktiven Umgangs mit dem Computer
Authors: Jöckel Sven
Published: March 2020

Rezension zu: Cermak-Sassenrath, Daniel. 2010. Interaktivität als Spiel: neue Perspektiven auf den Alltag mit dem Computer. Kultur- und Medientheorie. Bielefeld: transcript.
Wikipedia - Spiegel einer neuen Wissenskultur?
Authors: Kuttner Claudia
Published: March 2020

Rezension zu: Pscheida, Daniela. 2010. Das Wikipedia-Universum: wie das Internet unsere Wissenskultur verändert. Kultur- und Medientheorie. Bielefeld: Transcript.
Machtstrukturen und -beziehungen von Suchmaschinen
Authors: Berek Mathias
Published: March 2020

Rezension zu: Röhle, Theo. 2010. Der Google-Komplex: über Macht im Zeitalter des Internets. Kultur- und Medientheorie. Bielefeld: Transcript.
Medien, Kommunikation und Kultur im Zusammenspiel
Authors: Kübler Hans-Dieter
Published: March 2020

Rezension zu: Jäger, Ludwig, Erika Linz, und Irmela Schneider, Hrsg. 2010. Media, Culture, and Mediality: New Insights into the Current State of Research. Cultural and Media Studies. Bielefeld: Transcript.
Filmbildung
Authors: Ruge Wolfgang B.
Published: March 2020

Rezension zu: Zahn, Manuel. 2012. Ästhetische Film-Bildung: Studien zur Materialität und Medialität filmischer Bildungsprozesse. Theorie bilden, Bd. 28. Bielefeld: transcript.
Mediendidaktik zwischen Wissenschaft und Praxis
Authors: Hofhues Sandra
Published: March 2020

Rezension zu: Petko, Dominik. 2014. Einführung in die Mediendidaktik: Lehren und Lernen mit digitalen Medien. Bildungswissen Lehramt 25. Weinheim: Beltz.
Partizipative Medienkulturen
Authors: Meyer Philip
Published: March 2020

Rezension zu: Biermann, Ralf, Johannes Fromme, und Dan Verständig, Hrsg. 2014. Partizipative Medienkulturen: Positionen und Untersuchungen zu veränderten Formen öffentlicher Teilhabe. Medienbildung und Gesellschaft, Band 25. Wiesbaden: Springer VS.
Spielend Lernen oder ernstes Spielen?
Authors: Rau Franco
Published: March 2020

Rezension zu: Gundolf S. Freyermuth, Lisa Gotto und Fabian Wallenfels, Hrsg. Serious Games, Exergames, Exerlearning: Zur Transmedialisierung und Gamification des Wissenstransfers. Bielefeld: transcript, 2013
Rezension zu Hofmann & Lassacher (2013): Kino erleben und begreifen: Filmanalyse mit Kindern und Jugendlichen
Authors: Hackenberg Achim
Published: March 2020

Rezension zu: Anna Hofmann und Martina Lassacher, Hrsg. Kino erleben und begreifen: Filmanalyse mit Kindern und Jugendlichen. Wien: Facultas, 2013
Medienwelten als pädagogische Herausforderung
Authors: Leineweber Christian
Published: March 2020

Rezension zu: Friederike von Gross, Dorothee M. Meister und Uwe Sander, Hrsg. Medienpädagogik – ein Überblick. Weinheim und Basel: Beltz Juventa, 2015
Potenziale eines ‚Dispositive Turn‘ in der Medienpädagogik
Authors: Bettinger Patrick , Dander Valentin
Published: March 2020

Rezension zu: Caborn Wengler, Joannah, Britta Hoffarth, und Łukasz Kumięga, Hrsg. 2013. Verortungen des Dispositiv-Begriffs. Analytische Einsätze zu Raum, Bildung, Politik. Wiesbaden: Springer Fachmedien Wiesbaden. doi:10.1007/978-3-531-94260-5.
Rezension zu Plenk (2014): Die Perspektive der Kinder auf Qualität im Kinderfernsehen
Authors: Mertes Kathrin
Published: March 2020

Rezension zu Plenk, Astrid. 2014. Die Perspektive der Kinder auf Qualität im Kinderfernsehen. Hamburg: Verlag Dr. Kovac.
Rezension zu Strauch & Engelke (2016): Filme machen
Authors: Kamin Anna-Maria
Published: March 2020

Rezension zu Strauch, Thomas, und Carsten Engelke. 2016. Filme machen. Paderborn: Wilhelm Fink Verlag, UTB 4633
«Sociotechnical imaginaries» von Lernen, Regieren und Forschen mit datenbasierten Bildungstechnologien
Authors: Dander Valentin
Published: March 2020

Rezension zu Ben Williamson. 2017. Big Data in Education. The digital future of learning, policy and practice. London; Thousand Oaks; New Delhi; Singapore: SAGE
Rezension: Hate Speech und Verletzbarkeit im digitalen Zeitalter
Authors: Hoffarth Britta
Published: March 2020

Rezension zu: Eickelmann, Jennifer. 2017. Hate Speech und Verletzbarkeit im digitalen Zeitalter. Phänomene mediatisierter Missachtung aus Perspektive der Gender Media Studies Bielefeld: transcript. 325 Seiten ISBN: 978-3-8376-4053-3
Characterization of Gemcitabine Loaded Polyhydroxybutyrate Coated Magnetic Nanoparticles for Targeted Drug Delivery
Authors: Parsian Maryam , Mutlu Pelin , Yalcin Serap , Gunduz Ufuk
Published: March 2020

Background:

Targeted drug delivery is one of the recent hot topics in cancer therapy. Because of
having a targeting potential under the magnetic field and a suitable surface for the attachment of different therapeutic
moieties, magnetic nanoparticles are widely studied for their applications in medicine.

Objective:

Gemcitabine loaded polyhydroxybutyrate coated magnetic nanoparticles (Gem-PHB-MNPs) were
synthesized and characterized for the treatment of breast cancer by the targeted drug delivery method.

Methods:

The characterization of nanoparticles was confirmed by FTIR, XPS, TEM, and spectrophotometric
analyses. The cytotoxicities of drug-free nanoparticles and Gemcitabine loaded nanoparticles were determined
with cell proliferation assay using SKBR-3 and MCF-7 breast cancer cell lines.

Result:

The release of Gemcitabine from PHB-MNPs indicated a pH-dependent pattern, which is a desirable
release characteristic, since the pH of the tumor microenvironment and endosomal structures are acidic, while
bloodstream and healthy-tissues are neutral. Drug-free PHB-MNPs were not cytotoxic to the SKBR-3 and MCF-
7 cells, whereas the Gemcitabine loaded PHB-MNPs was about two-fold as cytotoxic with respect to free Gemcitabine.
In vitro targeting ability of PHB-MNPs was shown under the magnetic field.

Conclusion:

Considering these facts, we may suggest that these nanoparticles can be a promising candidate for
the development of a novel targeted drug delivery system for breast cancer.
Lauric Acid Modulates Cancer-Associated microRNA Expression and Inhibits the Growth of the Cancer Cell
Authors: Verma Poonam , Ghosh Amit , Ray Manisha , Sarkar Saurav
Published: March 2020

Background:

microRNAs are known to regulate various protein-coding gene expression posttranscriptionally.
Fatty acids are cell membrane constituents and are also known to influence the biological
activities of the cells like signal transduction, growth and differentiation of the cells, apoptosis induction, and
other physiological functions. In our experiments, we used lauric acid to analyse its effects on human cancerous
cell lines.

Objective:

Our objective was to speculate the miRNA expression profile in lauric acid treated and untreated
cancerous cell lines and further study the metabolic pathways of the targeted tumour suppressor and oncogenes.

Methods:

The KB cells and HepG2 cells were treated with lauric acid and miRNA was isolated and the expression
of tumour suppressor and oncogenic miRNA was measured by quantitative PCR. The untreated cells were
used as control. The metabolic pathways of the target tumour suppressor and oncogenes were examined by
GeneMANIA software.

Results:

Interestingly, the lauric acid treatment suppresses the expression of oncogenic miRNA and significantly
upregulated the expression of some tumour suppressor miRNAs. GeneMANIA metabolic pathway revealed that
the upregulated tumour suppressor miRNAs regulate several cancer-associated pathways such as DNA damage,
signal transduction p53 class mediator, stem cell differentiation, cell growth, cell cycle phase transition, apoptotic
signalling pathway, cellular response to stress and radiation, etc. whereas oncogenic miRNAs regulate the
cancer-associated pathway like cell cycle phase transition, apoptotic signalling pathway, cell growth, response to
oxidative stress, immune response activating cell surface protein signalling pathway, cyclin-dependent protein
kinase activity, epidermal growth factor receptor signalling pathways, etc.

Conclusion:

In our study, we found that lauric acid works as an anticancer agent by altering the expression of
miRNAs.
Nuevos registros de licofitas y helechos para el estado de Puebla, México
Authors: Mendoza Ruiz Aniceto C. , Ceja Romero Jacqueline
Published: March 2020

Antecedentes y Objetivos: Son pocos los trabajos florísticos que se han publicado sobre licofitas y helechos (pteridofitas en conjunto) de Puebla, México, por lo que se considera muy probable que la riqueza de especies en el estado sea mayor a la que se tiene documentada hasta el momento. El objetivo de este trabajo es reportar nuevos registros de este grupo de plantas para la entidad, incluyendo su distribución municipal y altitudinal, así como el tipo de vegetación en que se presentan.
Métodos: De 2010 a 2018 se efectuaron diversos viajes de recolección a distintas localidades de Puebla, durante los cuales se recolectaron y herbori­zaron ejemplares de licofitas y helechos, que fueron identificados y depositados en el Herbario de la Universidad Autónoma Metropolitana-Iztapalapa (UAMIZ). La información generada se confrontó con la lista de especies reportadas en la literatura para la entidad, lo que permitió reconocer los nuevos registros.
Resultados clave: Se documenta por primera vez para Puebla la presencia de 32 especies y un híbrido de licofitas y helechos, la mayoría de las cuales pertenecen a las familias Pteridaceae, Dryopteridaceae y Aspleniaceae, crecen en bosque mesófilo de montaña y vegetación derivada de bosque tropical perennifolio, entre 250 y 2500 m de altura.
Conclusiones: Los nuevos registros incrementan de 335 a 367 el número de especies de licofitas y helechos que habitan en el estado de Puebla y ponen en evidencia la necesidad de continuar con el trabajo de exploración en la entidad.
Caracterización morfológica y faneróptica de hembras Ovino de Pelo Criollo Colombiano “OPC” Sudán
Authors: Flórez Murillo Julio Mateo , Hernández Pérez Marcos De Jesús , Bustamante Yánez Moris De Jesús , Vergara Garay Oscar David
Published: March 2020

Objetivo. Esta investigación tuvo como objetivo describir la morfología cualitativa y faneróptica de hembras Ovino de Pelo Criollo Colombiano (OPC) Sudán. Materiales y métodos. Se evaluaron seis características fanerópticas y siete morfológicas cualitativas en 115 hembras Sudán Bayo y Sudán Blanco, de los departamentos Córdoba, Cesar y La Guajira. Los datos obtenidos se analizaron a través del programa estadístico InfoStat® y se estimaron las frecuencias relativas y absolutas para cada uno de los caracteres evaluados. Resultados. Los OPC Sudán Bayo se distinguieron por ser de un color de capa bayo amarillo. Los Sudán Blanco fueron de capa overo castaño, pero predominando siempre el blanco sobre el castaño. Estos ovinos se caracterizaron por poseer mucosas negra-rosadas y en menor proporción habían individuos con mucosas rosadas. Además, presentaron orejas horizontales siempre, perfiles subconvexos en más del 80% de los casos, cuellos generalmente medianos y poco musculados, grupas usualmente inclinadas, ubres parcialmente pigmentadas y también despigmentadas. Asimismo, se caracterizaron por ostentar pezuñas veteadas mayoritariamente, aunque con un alto porcentaje de pezuñas claras en las Sudán Blanco. Conclusiones. Este trabajo ha permitido caracterizar de manera específica a las OPC Sudán desde la morfología y la faneróptica, obteniéndose así información de importancia para delimitar los parámetros de pertenencia a este grupo y para la propuesta de creación de un estándar racial.
Thresholding-based White Blood Cells Segmentation from Microscopic Blood Images
Authors: Mohammed Zhana Fidakar , Abdulla Alan Anwer
Published: March 2020

Digital image processing has a significant role in different research areas, including medical image processing, object detection, biometrics, information hiding, and image compression. Image segmentation, which is one of the most important steps in processing medical image, makes the objects inside images more meaningful. For example, from microscopic images, blood cancer can be identified which is known as leukemia; for this purpose at first, the white blood cells (WBCs) need to be segmented. This paper focuses on developing a segmentation technique for segmenting WBCs from microscopic blood images based on thresholding segmentation technique and it compares with the most commonly used segmentation technique which is known as color-k-means clustering. The comparison is done based on three well-known measurements, used for evaluating segmentation techniques which are probability random index, variance of information, and global consistency error. Experimental results demonstrate that the proposed thresholding-based segmentation technique provides better results compared to color-k-means clustering technique for segmenting WBCs as well as the time consumption of the proposed technique is less than the color-k-means which are 70.8144 ms and 204.7188 ms, respectively.
How Caregivers of People With Dementia Search for Dementia-Specific Information on the Internet: Survey Study
Authors: Efthymiou Areti , Papastavrou Evridiki , Middleton Nicos , Markatou Artemis , Sakka Paraskevi
Published: March 2020

Background

During the last decade, more research has focused on web-based interventions delivered to support caregivers of people with dementia. However, little information is available in relation to internet use among caregivers in general, especially those caring for people with dementia.

Objective

The aim of this study was to evaluate the dementia-related internet use and factors that may be associated with its use among caregivers of people with dementia in Greece.

Methods

Secondary data from the Greek Dementia Survey of the Athens Association of Alzheimer’s Disease and Related Disorders were collected from April to June 2017. A total of 580 caregivers of people with dementia participated in the study.

Results

The majority of the caregivers reported that they had used the internet in the previous 3 months (84.1%, 488/580). Nearly half of the caregivers (47.5%, 276/580) reported that they had received dementia services online. Bivariate analysis showed that a dementia-specific search of information was associated with age, education, kinship, and years of care. Age (odds ratio [OR] 2.362, 95% CI 1.05-5.33) and education (OR 2.228, 95% CI 1.01-4.94) were confirmed as predictors, with younger caregivers and those with higher educational attainment being more likely to search for dementia-specific information. Use of the internet to search for dementia information was only related to hours of care. The internet use by caregivers within the previous 3 months was associated with variables such as age, education, occupation, kinship, years of care, and self-reported impact on physical and social health.

Conclusions

Caregivers of people with dementia in Greece, as in the other southern European countries, are essential agents of the national health system. The existing short- and long-term respite care services are limited or nonexistent. Currently, caregivers receive mostly support and education from memory clinics and municipality consultation centers, which are mainly based in central cities in Greece. Despite the dementia awareness movement in Greece, there is still space to integrate the role of technology in the support and education of caregivers. Development of training programs for enhancing electronic health literacy skills as well as web-based services provision could support Greek caregivers in their everyday caring tasks.
Digital Patient-Reported Outcome Measures for Monitoring of Patients on Cancer Treatment: Cross-sectional Questionnaire Study (Preprint)
Authors: Sivanandan Mayuran Ananth , Sharma Catherine , Bullard Pippa , Christian Judith
Published: March 2020

BACKGROUND

Oncology has been facing increasing outpatient activity associated with higher cancer incidence, better survival rates, and more treatment options. Innovative technological solutions could help deal with this increasing demand. Using digital patient-reported outcome measures (PROMs) to identify patients who need a face-to-face (FTF) appointment is a potential approach.

OBJECTIVE

This study aims to assess the feasibility of digital PROM questionnaires to enable remote symptom monitoring for patients undergoing cancer treatment and their ability to highlight the requirement for an FTF appointment.

METHODS

This study was performed at a tertiary oncology center between December 2018 and February 2019. The Common Terminology Criteria for Adverse Events were adapted into patient-friendly language to form the basis of treatment-specific digital questionnaires covering specific cancer drugs and radiotherapy treatments. These treatment-specific digital PROM questionnaires were scored by both patients and their clinicians during FTF appointments. Patients and clinicians did not see each other’s scored PROMs. Agreement between patients and clinicians was assessed using descriptive statistics. Patient and staff feedback was also obtained.

RESULTS

In total, 90 patients participated in the study across 10 different treatment pathways. By comparing paired patient and clinician responses, the sensitivity of the patient-completed questionnaires in correctly highlighting the need for FTF review was 94% (44/47), and all patients with severe or grade 3+ symptoms were identified (6/6, 100%). Patient-completed PROMs appropriately revealed that 29% (26/90) of the participating patients did not need FTF review based on their symptoms alone. Certain oncological treatment pathways, such as immunotherapy, were found to have a larger proportion of patients with minimal symptoms than others, such as conventional chemotherapy. Patient and staff feedback showed high approval of digital PROMs and their potential for use in remote monitoring.

CONCLUSIONS

Digital PROM questionnaires can feasibly highlight the need for FTF review in oncology clinics for treatment. Their use with specific treatments could safely reduce the requirement for FTF care, and future work should evaluate their application in the remote monitoring of patients.

CLINICALTRIAL
Sedentariness and Back Health in Western Cape Primary School Students: Protocol for a Pragmatic Stepped-Wedge Feasibility Randomized Controlled Trial (Preprint)
Authors: Fisher Dominic , Louw Quinette , Thabane Lehana
Published: March 2020

BACKGROUND

Despite growing evidence of deleterious health outcomes associated with sedentary behavior, prolonged static sitting in classrooms remains ubiquitous in primary schools. Sedentary behavior is associated with the development of cardio-metabolic conditions and poor back health. Preventative strategies to reduce sedentary behavior and its negative health effects may be required in a resource-constrained environment such as South Africa.

OBJECTIVE

The primary objective of this study is to assess the feasibility of conducting a full trial to evaluate the effects of a multifaceted intervention comprising novel multifunctional classroom furniture and a video-based curriculum versus usual care on sedentary behavior among students aged 10-11 years in primary schools. The secondary objective is to assess the preliminary effects of the intervention on sedentary behavior and postural dynamism.

METHODS

Eighty grade 5 or 6 students, aged 10 and 11 years, in mixed-gender schools within the Western Cape metropolitan urban area in Cape Town, South Africa are eligible to participate in this pilot cluster stepped-wedge trial design with classroom as the unit of randomization. Data will be collected at the schools. The intervention will comprise multifunctional classroom furniture that allows for sitting and standing as well as a video-based curriculum on sedentary behavior. Usual practice is the absence of the intervention. The primary outcomes assessed will be (1) adherence to the intervention and (2) project pragmatics. The secondary outcomes will be (1) sedentariness measured using activPAL3 microsensors and (2) postural dynamism measured using Noraxon Myomotion inertial measurement units. We randomized the school to the first or second start of the intervention. This is an open-label trial and therefore blinding will not be possible for any group. Descriptive analysis of the feasibility and physiological outcomes will be presented. We will report the preliminary estimates of the effects of the intervention on sedentariness and postural dynamism using the mean difference and 95% CI.

RESULTS

At the time of submission, two classrooms have been recruited into the study. Baseline physical activity and postural dynamism data have been collected from 10 participants from each class.

CONCLUSIONS

The results of this feasibility stepped-wedge cluster randomized controlled trial will be useful in informing the design of the main trial to assess whether this multifaceted intervention of multifunctional classroom furniture that allows for sitting and standing as well as a video-based curriculum versus usual care has any effect on sedentary behavior in low-resource-setting primary schools.

CLINICALTRIAL

Pan African Trials Registry PACTR201811799476016; https://tinyurl.com/y4upoys8

INTERNATIONAL REGISTERED REPORT

RR1-10.2196/18522
Pengujian Keunggulan Empat Galur Harapan Tomat (Solanum lycopersicum L.)
Authors: Rahayu Yayuk Dwi , Murti Rudi Hari
Published: March 2020

Penelitian ini bertujuan mengetahui keunggulan masing-masing galur. Percobaan dilaksanakan di Balai Pengembangan dan Promosi Agribisnis Perbenihan Hortikultura (BPPAPH) Ngipiksari, Sleman, Daerah Istimewa Yogyakarta pada bulan Juni hingga November 2018. Bahan penelitian yang digunakan adalah empat galur harapan tomat (G6, G9, Gamato 1 dan Gamato 5) dan empat varietas pembanding (Intan, Ratna, Gondol Putih dan Gondol Hijau). Rancangan percobaan lapangan yang digunakan adalah Rancangan Acak Kelompok Lengkap (RAKL) dengan empat ulangan sebagai blok dan terdiri atas dua set percobaan (determinate dan indeterminate). Variabel pengamatan berupa karakter kuantitatif (tinggi tanaman, diameter batang, ukuran daun, umur berbunga, umur panen optimal, ukuran buah, rongga buah, tebal daging buah, padatan terlarut total, kekerasan buah, berat per buah, dan berat buah per tanaman). Data yang didapat dianalisis dengan Uji Kontras Ortogonal pada taraf nyata α%. Hasil penelitian menunjukkan galur G6 dan G9 memiliki umur panen (78,58 hst dan 82,67 hst) lebih cepat dibandingkan Intan (87,5 hst) dan Ratna (81,3 hst). Galur Gamato 1 dan Gamato 5 memiliki rerata bobot buah per butir (103,03 gram dan 111,4 gram) lebih berat dibandingkan Gondol Putih (58 gram) dan Gondol Hijau (72,10 gram). Rerata bobot buah per pohon galur Gamato 1 (1533,55 gram) dan Gamato 5 (1715,36 gram) lebih tinggi dari pembandingnya Gondol Putih (994,62 gram) dan Gondol Hijau (1380,24 gram). Kata kunci: keunggulan; tomat; galur harapan; dataran tinggi
Analysis on Basic Cognition and Representative Issues of the Income Distribution Pattern in China (Note 1)
Authors: Kang Jia
Published: March 2020

The analysis and recognition of China’s current income distribution pattern is a major practical issue that involves the idea and essentials of advancing modern state governance in the stage of economic and social transition, and also a controversial issue. In this paper, the author focused on two major points. First, the analysis on the basic situation of the proportion of resident income in the overall income distribution pattern in recent decade in China, which first went down and then rose slightly, is conducted. Then the paper emphasized that the key to solve the paradox formed by two mainstream views was to understand more deeply the institutional causes of the unfairness and non-standardization inherent in high Gini coefficient of income distribution in China, which was an essential real problem. Second, based on an examination of the significance of cultivating and developing the mid-income class in China, the serious shortcomings of official statistics about income quintile information must be pointed out. Thus, it is imperative to recognize the covered contradictions, face the anxiety state and related challenges that the mid-income class in China has been stuck in, and then seek to solve the contradiction and eliminate the anxiety in a targeted manner.
EVALUATION OF ORALLY DISINTEGRATING TABLET OF IBUPROFEN-β-CYCLODEXTRIN INCLUSION COMPLEX
Authors: PURNAMASARI NUR AINI DEWI , SAPUTRA PRATAMA ANGGI
Published: March 2020

Objective: This study aims to determine the effect of the inclusion complex formation of ibuprofen (IB) with β-cyclodextrin (β-CD) in improving water solubility and taste masking as well as to study the effect of the combined use of super disintegrants in IB-β-CD ODT (Orally disintegrating tablet).

Methods: IB-β-CD inclusion complex was prepared by spray drying technique with a 1:1 molar ratio. ODTs were prepared by the direct compression method using various ratios of Ac-Di-Sol® and Kollidon® CL as super disintegrant. The inclusion complex was characterized using spectroscopy FT-IR (Fourier-transform infrared) and DSC (Differential Scanning Calorimetry). The physical properties and dissolution rate of ODTs were evaluated. Dissolved drug concentration at 60 min (Q60) and Dissolution Efficiency (DE60) was calculated using the dissolution test result.

Results: The unpleasant taste of IB had been successfully masked by IB-β-CD. Formula 1 was observed having 14.5 sec of disintegration, fastest compared to the other formulas. Moreover DE60 value of formula I was higher than the other formulas (113.45).

Conclusion: IB-β-CD Inclusion complex prepared by spray drying method (1: 1) increased the water solubility and masked the unpleasant taste compared to IB moreover combination of Ac-Di-Sol® and Kollidon® CL increased ODT dissolution rate.
A REVIEW ON PHYSICO-CHEMICAL PARAMETERS OF LIPOSOMAL DOXORUBICIN
Authors: SINGH DEEPANMOL , PAHWA SHILPA
Published: March 2020

The development of a generic liposomal doxorubicin product requires the study of critical physicochemical properties of the formulation. Food and Drug Administration (FDA) draft guideline has suggested few parameters to be tested for in vitro bioequivalence study which include liposomal composition, state of encapsulated drug, internal environment, liposomal morphology and number of lamellae, lipid bilayer phase transition, liposomal size distribution, grafted Polyethylene Glycol (PEG) at liposomal surface, electric surface potential or charge and in vitro leakage under multiple conditions. Characteristic features of components of liposomal doxorubicin formulation and detail of parameters to be studied have been discussed. This review compile specific, current and historical research outcomes on in vitro analysis of liposomal doxorubicin and highlights the important features that have a critical impact on properties of liposomal doxorubicin formulation. It will provide a better insight to the generic manufacturers and will help them to identify the critical quality attributes during the formulation development phase.
THE THE EFFECT OF ALMOND OIL ON THE PERMEABILITY OF KETOPROFEN HYDROGEL
Authors: HASAN ZAHRAA ALAA , AL-MOUSAWY JINAN MUHAMMED MUHSIN , ALGHURABI HAMID SADEQ KHALEEL
Published: March 2020

Objective: The object of this study is to formulate ketoprofen hydrogels and to evaluate their permeability following the incorporation of almond oil as a penetration enhancer.

Methods: Five formulas (F2-F6) of ketoprofen hydrogels were formulated with the employment of carbopol 940 and triethanolamine. A gradual increase in the amount of almond oil was used in each formula. In vitro penetration and release kinetic study was conducted for all the formulations and compared with the control formula (F1) which was prepared without the incorporation of almond oil.

Results: There was a strong positive correlation between % of incorporated almond oil and the % of drug released when the samples were compared with F1 that was formulated without almond oil. After 24 h, 90% of medication was penetrated from ketoprofen hydrogel formulation (F6), which had 5% almond oil.

Conclusion: Almond oil has successfully worked as a natural penetration enhancer when five ketoprofen hydrogel formulations were prepared and evaluated.
THE OPTIMIZATION OF RP-HPLC CONDITION USING RESPONSE SURFACE METHODOLOGY BOX-BEHNKEN DESIGN FOR SIMULTANEOUS DETERMINATION OF METFORMIN HCL AND GLIMEPIRIDE IN SPIKED PLASMA
Authors: IZMA HAYATUN , MARTONO SUDIBYO , LUKITANINGSIH ENDANG
Published: March 2020

Objective: Aim of this study was to develop and validate the RP-HPLC method using Box-Behnken Design (BBD) for simultaneous analysis metformin HCl and glimepiride in spiked plasma.

Methods: The chromatographic system was comprised of acetonitrile-phosphate buffer 0.0125 M+Sodium Dodecyl Sulphate (SDS) 1 mmol as a mobile phase and Ascentis® Phenyl C18 (250 x 4.6 mm i.d.; 5 µm) column as a stationary phase with UV detector at 210 nm. Three independent variables included phosphate buffer (%), pH and flow rate were optimized using Box-Behnken Design. The observed responses were retention time, peak area and resolution.

Results: The predicted optimum condition of the RP-HPLC system consisted of phosphate buffer solution of 72%, pH at 4.3 and flow rate at 0.8 ml/min. By using this condition, the duration of analysis was more than 18 min, so it was necessary to modify the flow rate to be 1.0 ml/min to get shorter analysis duration. This condition was then applied to analyze metformin and glimepiride in spiked plasma and validated according to the EMA guideline. AUC of interfering components at the IS retention time between 588-1092 mV, the linearity of metformin was 0.9993 and glimepiride was 0.9991, accuracy and precision were between-13.33% until 16.08%, dilution integrity and metformin stability studies were between-4.01% until 11.82%, and for glimepiride stability studies were between-37.48% until-4.76%.

Conclusion: Box-Behnken Design can help optimize the HPLC system, and the optimum condition was valid to analyze metformin and glimepiride in spiked plasma by considering the storage time of plasma samples.
A A COMPARATIVE STUDY OF QUALITY CONTROL TESTING ON CANDESARTAN CILEXETIL CONVENTIONAL TABLETS IN IRAQ
Authors: ALBO HAMRAH KARRAR TALIB KHUDHAIR , AL-SHAIBANI ABULFADHEL JABER NEAMAH , AL-EDRESI SARMAD SABAH , AL-GBURI KARRAR MOHAMMED HASAN
Published: March 2020

Objective: The present study was performed to compare the quality of conventional tablets loaded with candesartan cilexetil. The selected candesartan cilexetil tablets were commercialized in the Iraq market and produced by different companies. 

Methods: Different batches of candesartan cilexetil oral tablets (the concentration of candesartan was 8 mg) were subjected to quality control tests. Tests included weight variation, friability, hardness, drug content, disintegration time and in vitro release study. The protocols of these tests were performed according to USP pharmacopeia.

Results: The results, in this study, revealed that all the used batches of candesartan cilexetil oral tablets complied with the specification of USP pharmacopeia for weight uniformity, friability value (% loss) was<1. Hardness results of the tablets were 4.9-6.6 Kg/cm2, which was within the required limits (i.e. 4-8 Kg/cm2). Disintegration time was<15 min in both Simulated Gastric Fluid (SGF) and Simulated Intestinal Fluid (SIF). The percentage of drug content in all marketed tablets was found between 96.2 % and 99.8 %, reflecting compliance with the pharmacopeia limits (i.e. 85-115 %). An in vitro release study indicated that the release of all marketed tablets exceeds 80 % within 15 min.

Conclusion: All the studied tablets, loaded with candesartan cilexetil, were produced within the standard criteria of tablet production. The quality control analysis of the selected tablets, in this study, revealed satisfactory pharmaceutical properties (including safety and effectiveness) that comply within the limits of USP pharmacopeia.
PREPARATION, CHARACTERIZATION AND STABILITY STUDIES OF SOLID SELF EMULSIFYING DRUG DELIVERY SYSTEM OF NIFEDIPINE
Authors: BINDHANI SABITRI , MOHAPATRA SNEHAMAYEE , KAR RAJAT KUMAR
Published: March 2020

Objective: The objective of this work was to improve the solubility and dissolution rate of Nifedipine by preparing a solid-self micro emulsifying drug delivery system (Solid-smedds).

Methods: Liquid-self-emulsifying drug delivery system formulations were prepared by using linseed oil as oil, tween 80 as a surfactant and PEG 400 as cosurfactant. Components were selected by solubility screening studies and the self-emulsifying region was identified by the pseudo-ternary phase diagram. Thermodynamic stability study was performed for the determination of stable liquid-smedds formulation. These formulations were evaluated for self-emulsification time, drug content analysis, robustness to dilution test, particle size analysis, in vitro diffusion study, and Stability study. Solid self-micro emulsifying formulations were prepared by using aerosil-200 at a different ratio. Lf9S (0.65:1) was selected due to its highest drug entrapment efficiency and a decrease in particle size. It was selected for further studies into DSC, SEM, FTIR, and XRD analysis.

Results: DSC and XRD result shows that the drug within the formulation was in the amorphous state. From the SEM study, it was observed that the drug has been uniformly distributed and having a smooth surface. From the in vitro dissolution study, it improved the dissolution rate of nifedipine which was 98.70% of drug release where pure drug release only 6.72%.

Conclusion: In conclusion, a solid self-micro emulsifying drug delivery system is improved the solubility and drug release rate but also improved the stability of the formulation.
TOPICAL ANTI-PSORIATIC NANOPARTICULATE DRUG DELIVERY SYSTEM
Authors: BHISE KIRAN , KHAN SHADAB , MULLA GHAZALA
Published: March 2020

Objective: Development of effective drug delivery in the treatment of psoriasis is the major challenge for its successful management. To develop and assess the potential of Nanostructured Lipid Carriers (NLCs) enriched with the powdered leaves extracts of Azadirachta indica (AE), Lawsonia inermis (LE) and fruit extract of Mallotus philippensis (ME) in the management of psoriasis.

Methods: Drug loaded NLCs were prepared via hot homogenization technique by adopting 23 factorial design with factors X1 as the concentration of lipids, X2 concentration of surfactants and X3 being the number of homogenization cycle. The responses Y1 and Y2 were particle size and zeta potential. The optimized batch was obtained from Surface response plot and was evaluated for zeta potential, % entrapment efficiency, % drug loading, Scanning Electron Microscopy(SEM), % in vitro diffusion of drugs from the NLCs, anti-lipid peroxidation and nitric oxide scavenging activities, cytotoxicity on HaCat cell lines, Mouse Tail and Rat ultraviolet ray B photodermatitis models for Psoriasis.

Results: The optimized batch of NLCs was found within the nanosized range with a relatively low polydispersity index and zeta potential of-20mV. The %EE for an optimized batch of NLCs was found to be 98.97±0.83%, 96.99±0.56% and 99.25±0.55% and the %DL of 21.84±0.15%, 8.55±045%, and 87.91±0.38% respectively for AE, LE and ME.

The SEM images showed the spherical vesicular structures of drugs loaded NLCs. The in-vitro diffusion of drugs from the NLCs followed initial burst release thereafter sustained release for 24 h. The AE, LE and ME loaded NLCs proved to possess anti-lipid peroxidation and nitric oxide scavenging activities, cytotoxicity on HaCat cell lines, DNA fragmentation on HaCat cell lines which are biomarkers in the pathogenesis of psoriasis. The results of Mouse Tail and Rat ultraviolet ray B photodermatitis models for Psoriasis supported the anti-psoriatic potential of AE, LE and ME loaded NLCs.

Conclusion: AE, LE and ME loaded NLCs can be used for prolonged topical delivery to the psoriatic skin for an effective treatment.
Pengawasan Internal Perspektif Maqāṣid Al-Syarīʻah (Analisis Peraturan Pemerintah No. 60 Tahun 2008 tentang Sistem Pengendalian Intern Pemerintah)
Authors: Sabil Jabbar , Hasanah Rizkaul , Abdullah Arifin
Published: March 2020

Abstrak: Tujuan penelitian adalah untuk mengetahui bagaimana perspektif maqāṣid al-syarīʻah terhadap pengawasan internal yang terkandung dalam Peraturan Pemerintah No. 60 Tahun 2008 tentang Sistem Pengendalian Intern Pemerintah. Penelitian dilakukan dengan metode penelitian kepustakaan dengan pendekatan yuridis-normatif yang dipadukan dengan pendekatan maqāṣidī. Hasil penelitian menunjukkan bahwa pengawasan internal secara maqāṣid al-syarīʻah, dianggap sebagai bagian dari al-maṣlaḥah al-ḥājjiyyah, dan berfungsi sebagai wasā‟il (sarana). Pengawasan internal merupakan sarana untuk memudahkan penyelenggaraan pelayanan publik supaya dapat berjalan sesuai dengan aturan yang telah Allah tetapkan. Pengawasan internal merupakan bagian dari pemeliharaan agama dan harta dalam wujud pelaksanaan amar makruf nahi mungkar dan pertanggung  jawaban  terhadap  amanah  serta  pemeliharaan  atas  harta  umum  (public  fund). Sehingga dapat disimpulkan bahwa secara umum konsep pengawasan internal yang diamanahkan dalam Peraturan Pemerintah tersebut telah sesuai dengan apa yang diinginkan oleh syarak, hanya saja masih harus dilakukan penyempurnaan pada sistem pengawasannya agar apa yang diinginkan oleh syarak dapat terimplementasi dengan baik.Abstract: The aim of the research is to find out how the perspective of maqāṣid al-syarīʻah towards internal supervision contained in Government Regulation No. 60 of 2008 About the Government Internal Control System. The study was conducted with a literature research method with a juridical-normative approach combined with the maqāṣidī approach. The results showed that internal supervision by maqāṣid al-syarīʻah, was considered as part of al-maṣlaḥah al-jiājjiyyah, and functioned as wasā'il (means). Internal supervision is a means to facilitate the implementation of public services so that they can run according to the rules that God has set. Internal supervision is part of the maintenance of religion and assets in the form of the implementation of amar makruf nahi mungkar and accountability for the mandate and maintenance of public assets (public funds). So it can be concluded that in general the concept of internal supervision mandated in the Government Regulation is in accordance with what is desired by the sharak, only that improvements must be made to its monitoring system so that what is desired by the sharak can be implemented properly.
Los límites y las posibilidades del modelo de aprendizaje centrado en el alumno en una cultura escolar caracterizada por el centralismo, la imposición y el control
Authors: Valdés Dávila Ma. Guadalupe
Published: March 2020

Los aspectos puntuales del cambio radical que se promueve a partir de la revolución tecnológica constituyen un marco de referencia que permite entender por qué los sistemas e instituciones educativas han modificado sustancialmente su currículum a fin de dar respuestas oportunas a los retos y demandas que plantea el entorno globalizado.Transitar de la enseñanza al aprendizaje es un cambio que, por decreto a nivel de la política educativa, los docentes han de realizar. Esta reforma educativa a nivel discursivo presenta múltiples bondades, pero asumirla, encarnarla en la vida de las aulas, representa reto y dificultad. El cambio educativo puede ser preciso, relativamente fácil y rápido en la dimensión de la política curricular, en los aspectos estructurales, pero la transformación en profundidad de los procesos educativos en el aula, en lo cotidiano del día a día resulta mucho más compleja, precisamente porque el cambio se incita en una cultura escolar que sigue anclada a las características heredadas por la modernidad.
Entre significados de estudiantes del aprendizaje escolar y miradas docentes y no docentes de la modalidad de educación permanente en contextos vulnerables de la zona sur de la Ciudad de Buenos Aires
Authors: Facciola Mariana C.
Published: March 2020

En el presente artículo se presentan los resultados parciales acerca de la exploración de los significados atribuidos al aprendizaje escolar de jóvenes y adultos (n17) deuna escuela media de adultos del barrio de la zona sur de la Ciudad de Buenos Aires. Los mismos se obtuvieron por entrevistas semiestructurada y fueron analizadas por métodocomparativo constante. Se construyeron veintiún códigos y cinco categorías: el aprendizaje como promotor del saber y del ser alguien requiere de esfuerzo y motivación. Seidentifican factores subjetivos y sociales que dificultan el proceso, así como también redes de ayuda que facilitan el aprendizaje. Las categorías emergentes constituyeron labase del diseño de la encuesta cuyas preguntas abiertas y cerradas fueron tomadas a docentes y no docentes de la modalidad (n73). En el análisis de las preguntas abiertasse identificaron dos tipos de miradas acerca de los sujetos de aprendizaje: quienes consideran a los jóvenes y adultos como sujetos pasivos, víctimas de las situaciones familiares,escolares y económicas y otra que los considera como sujetos activos, actores de su propia vida y constructores de otros futuros posibles. Se concluye que las miradas de los docentes y no docentes ejercen una influencia simbólica significativa y son predictores de futuro para los sujetos de la modalidad. Esta polarización de miradas reclama un trabajo de explicitación y revisión de prácticas profesionales.
La construcción narrativa del aprendizaje
Authors: González García Javier
Published: March 2020

El artículo analiza el uso y la dimensión social de las narraciones en la escuelabásica, orientados por enfoques constructivistas. Para ello, se formulan tres preguntascomo punto de partida: ¿cómo construimos significados a partir de narraciones?; ¿son las narraciones un puente entre cognición y emoción?; ¿la narración contribuyeal desarrollo de una identidad cultural?. El intento de respuesta a cada una de estas cuestiones aporta una serie de funciones educativas: las narraciones pueden dar formaa experiencias, vivencias y conocimientos en un todo comprensible que funciona como una zona de desarrollo próximo; contribuyen al intercambio entre cognición yemoción desarrollando la imaginación; y juegan un papel clave en la creación, aceptación, o rechazo de una identidad cultural.
Sistemas alternativos y aumentativos de comunicación para el tratamiento de niños con trastorno del espectro autista
Authors: Echeguia Cudolá Jimena
Published: March 2020

En el abordaje terapéutico de los niños con trastorno del espectro autista (TEA), esfundamental incorporar la construcción y utilización de los sistemas alternativos yaumentativos de comunicación (SAAC). Los SAAC son un conjunto organizado de elementos no vocales para comunicar. No surgen espontáneamente, sino que se adquieren mediante un aprendizaje formal y deliberado. Mediante su aplicación, se favorece el desarrollo del lenguaje oral y se proveen herramientas para que el niño comience a interactuar con el medio, garantizando de esta forma un pleno e integral desarrollo del sujeto (Valdez, 2012). Solo de esta manera es que podemos pensar en una verdadera inclusión del niño en el ámbito escolar y social. Esto se sustenta a partir de lo trabajado y observado en la práctica profesional de la autora de esta comunicación, como terapeuta en habilidades sociales y comunicación de niños con TEA.
Cash Settled Commodity Option Contracts as an Alternative to Minimum Support Price: A Mechanism to Alleviate Farmer Distress
Authors: Rama Murthy Y Sree
Published: March 2020

Cash settled commodity options is a possible alternative to create a mechanism so that minimum support prices work in reality and do not remain a paper exercise. This paper argues that the government should create a commodity options market for all minimum support price (MSP) commodities. Further option contracts should be cash settled. The government should participate by selling put options at or above the minimum support price, so that farmers can exercise the option if they find that market prices are below the minimum support price.
A hypothesis about the origin and administrative status of the Vardariōtai in the Byzantine empire
Authors: Cvetkovic Milos
Published: March 2020

The paper presents the results of research on some segments in the history of
the Vardari?tai. Starting from the generally accepted premise of their
Hungarian roots, the author attempts to answer the questions of when and how
the Vardari?tai made their way to the Byzantine Empire. The text also
proposes a hypothesis about the evolution of the administrative status of
the Vardariote community in the Empire from the early 10th century (the
first reference to them in the sources) to the early 13th century, when the
district they inhabited was unambiguously confirmed as an imperial
province/theme.
E-healthservices and devices: Availability, merits, and barriers - with some examples from Finland
Authors: Ahmadinia Hamed , Eriksson-Backa Kristina
Published: March 2020

Empowering individuals through e-health can be considered as the current trend in developing healthcare services and devices. The aim of this article is to shed light on availability, benefits, and limitations of using these services and devices in people’s everyday life. This study is a descriptive review based on a non-exhaustive selection of previous studies that define information exchange, information formats, opportunities, and restrictions of e-health technologies. The main focus of this study is on presenting available e-health services and devices while describing their benefits and limitations. This approach has the potential to provide new insights into the future development and integration of e-health into the healthcare system of a country. The idea behind this review is to provide a better understanding of e-health services for authorities, healthcare professionals, individuals, and related beneficiaries.