bluuebunny/crossref_metadata_2025 huggingface dataset:
Perspektif Kode Etik Jabatan Notaris terhadap Publikasi dan Promosi Jabatan Notaris melalui Aplikasi Android
Authors: Imanda Nadia
Published: March 2020

Abstract: The era of technology brings people to the development of sophisticated computers and smartphones in which the applications of various types and purposes are. Notary as a public official appointed by the state to take care of most countries and communities in the context of civil law, has legal provisions related to what may and may not be done by a Notary. In this case, the Notary Code of Ethics of the Indonesian Notary Association (INI) states that notaries are denied publication and self-promotion of their positions through writing media as well as electronic media, but the category of advertising on publicity and self-promotion does not provide clear interpretation on android application that indicates to violate the Article 4 paragraph (3) Notary Code of Ethics. This legal research uses normative research methods using the statute approach and conceptual approaches. The use of an android application by a notary who indicates committing violation must be studied and supervised from the Notary Honorary Board and Notary Supervisory Board  so that the inteniont and the purpose of the UUJN and the Notary Code of Ethics can be realized and the office of notary as a profession cannot be dishonored.  Abstrak: Era teknologi membawa manusia pada perkembangan komputer dan smartphone canggih yang di dalamnya terdapat fasilitas aplikasi berbagai macam jenis dan tujuan. Notaris sebagai pejabat umum yang diangkat oleh negara untuk mengurusi sebagian urusan negara dan masyarakat dalam lingkup hukum perdata, memiliki ketentuan hukum terkait apa yang boleh dan tidak boleh dilakukan oleh seorang Notaris. Dalam hal ini, Kode Etik Notaris Ikatan Notaris Indonesia (I.N.I) menyatakan bahwa notaris dilarang melak         ukan publikasi dan promosi diri terhadap jabatannya melalui media tulis mau pun media elektronik, namun kategori batasan terhadap publikasi dan promosi diri dinilai kurang memberikan kejelasan hukum bahwasanya ditemukan aplikasi android yang berindikasi pelanggaran Pasal 4 ayat (3) Kode Etik Notaris. Penelitian hukum ini menggunakan metode penelitian normatif dengan pendekatan berdasarkan perundang-undangan (statute approach) dan pendekatan konsep (conceptual approach). Penggunaan aplikasi android oleh notaris yang berindikasi melakukan pelanggaran harus dilakukan pengkajian dan pengawasan dari Dewan Kehormatan Notaris dan Majelis Pengawas Notaris agar maksud dan tujuan UUJN serta Kode Etik Notaris dapat terwujud dan tidak mencederai jabatan notaris sebagai profesi yang mulia.
SIMULATION OF IMAGE DATA TO SUPPORT THE TRAINING OF CONVOLUTIONAL NEURAL NETWORKS FOR OBJECTS RECOGNITION
Authors: Borstell Hagen , Nonnen Jan
Published: March 2020

The recognition of logistics objects is an essential prerequisite for the optimization of operational logistics processes and can be performed among others via image-based methods. However, the lack of available data for training domain-specific recognition models remains a practical problem. For this reason, we present an approach to solving this problem. The core principle of our approach is the automated generation of image data from 3D models, in which the appearance of the objects varies through variations of different parameters. The first results are promising: Without any real image data, we have created a neural network for recognition of real objects with a recall quality of 86%.
MECHANICAL VIBRATION AND SHOCK MEASUREMENT OF MATERIAL FLOW DEVICES AND SYSTEMS
Authors: Szentmiklósi István , Illés Béla
Published: March 2020

The article deals with the measurement and analysis of the vibration of material flow devices and systems. This work has been done to find out if and in what form kinetic energy arises in comprehensive material flow processes. In the first chapter the theory of vibration measurement from periodic vibration to transient effects will be described using their physical and mathematical foundations. In the second chapter will present the results of the large-scale measurements. A special focus is on the natural frequency of the individual material flow devices. It has to be examined whether it is a certain useful frequency of technical units such as trucks, conveyor belt, etc. egsist over the entire supply chain. At the beginning of the article, the theoretical basics of metrology will be described, then the results will be presented and then the results will be summarized and evaluated. At the very end, an outlook is given about the further steps of the work.
数字城市大比例尺DLG数据快速入库流程
Authors: 于 海涛
Published: March 2020

在数字城市的大比例尺DLG数据入库中，其相较于原有的工作形式具有更多的作用优势。要完全按照专业化的工作流程完成工作任务，在具体的研究中，需要完全按照当前的工作优势和专业化的管理制度，才能完成各项操作项目，并且要设定多个工作参数，才可以确保该系统的安全稳定运行，并且落实各项分析项目。
微波加热技术在贵金属分析中的应用探讨
Authors: 甘 黎明 , 贺 怡欣 , 呼 啸
Published: March 2020

微波加热技术是一项新技术，具有诸多应用优势，比如：加热均匀、超高的加热效率、清洁环保、操作简单等，在各领域被广泛应用。文章简要分析了微波加热技术的应用优势，并且详细列举了微波加热技术，在贵金属分析中的具体应用，探索微波加热技术的超强适用性。
探析信息化管理在公路试验检测中的应用
Authors: 徐 长峰
Published: March 2020

随着科学技术和经济的快速发展，人们已经进入了信息时代。在公路试验检测工作当中，信息管理工作起到了至关重要的作用，在提高公路试验检测的竞争实力、工作效率以及管理水平等方面都有着现实意义。
房屋建筑结构设计中优化技术应用分析
Authors: 蒋 威
Published: March 2020

文章首先从安全性、宜居性、环保性三个角度入手，分析了房屋建筑结构设计中优化技术的应用目标；其后，围绕主体结构、安全结构、布局结构三个方面，重点提出了房屋建筑结构设计中优化技术的可行应用策略。
试论我国对5G网络运营的需求
Authors: 范 华 , 王 姝力 , 彭 星
Published: March 2020

5G将实现信息随心至、万物触手及，是通信发展史的一次巨大的飞跃，因为前途光明，道路必定是曲折的,技术标准博弈、终端模组数量少且价格不菲、业务待孵化成熟等诸多困难，横在推进的道路上，前进的步伐艰难而沉重，我们要以怎样应对这场技术革新。
探析公路工程沥青路面施工技术与质量控制策略
Authors: 陈 恒
Published: March 2020

经济社会的高速发展使得我国有足够的经济实力去建设基础设施工程项目，同时基础设施的不断建设完善也推动了经济社会又好又快的发展，也给人们的生活带来了极大的便利。特别是近年来，为了满足区域间的沟通交流和人民日常出行的需要，道路工程项目的建设规模以及建造数量都在逐步增加。在道路工程项目的建造施工的过程中，沥青这种材料越来越多地被工程建设所使用，给道路工程项目的建造带来了很明显的性能提升，因此，为了更好的确保道路工程项目的建造施工质量，保障车辆在路面上的驾驶平稳安全，有必要做好道路工程项目建造过程中的监督管理工作，确保施工建筑材料的质量和标准，确保机械设备的运行正常平稳，确保施工建造人员可以保持高度的责任感，严格按照工程项目的建造标准和施工计划进行施工，及时处理工程施工过程中出现的问题，推动中国的交通系统的建设更高水平的发展。
探究智慧矿山建设架构体系及其关键技术
Authors: 张 炳辉
Published: March 2020

近年来，我国社会经济整体水平得到了显著的提升，从而带动了国内各个行业各个领域的不断进步，有效的促进了数字化信息技术的发展。煤矿行业因为自身的性质以及行业内信息交流具有一定的闭塞，最终导致各个煤矿企业对数字化技术的认同程度有所不同。智慧矿山其实质就是利用创建网络系统，借助人工智能以及智能分析的方法来促进煤矿企业的生产运营效率的不断提升，有效的解决当前煤矿行业内存在问题，带动整个行业稳定健康的发展。
浅谈大型LNG低温储罐的建造技术
Authors: 杨 小兵
Published: March 2020

现今有关液态天然气的开发项目逐渐增加，导致大型LNG低温储罐取得了良好的应用空间，若能严格把控建造技术可强化其性能。在此之上，文章简要分析了大型LNG低温储罐的结构特点与设计要求，并通过充分考虑强度、合理控制成本、自主设计形式、选用优质材料等要点，突出大型LNG低温储罐优势。
市政道路及设施的维修养护技术
Authors: 谭 成军
Published: March 2020

市政道路及设施投入使用后必须要做好长期的维修养护计划，利用各种维修养护技术来及时消除市政道路及设施在使用中的各种安全隐患，确保道路通行安全。文章对市政道路及设施的维修养护技术进行了探讨，首先分析了对市政道路及设施进行维修养护的意义所在，然后针对市政道路及设施维修养护工作当前存在的问题进行探讨，最后针对这些问题提出了维修养护工作的各类技术，为今后更好的开展市政道路及设施的维修养护工作提供参考。
基坑降水技术在建筑工程施工中的应用研究
Authors: 张 玉举
Published: March 2020

建筑工程项目的建造施工的整个过程中，必须要采取严格的管理措施和技术手段，确保工程项目建设的安全和高效，同时也要在这个过程中提升工程项目建造的经济效益，可以如期的按照当初的建造标准给业主方交付高品质的工程项目。如何保障工程项目的建设质量，需要多方共同努力，对于工程项目的施工人员来说，需要有效的了解和领悟施工标准和建造方案，结合施工环境的实际情况，选择更有适应性的建造技术，在施工过程中还要提高施工的管理和监督，确保施工过程中的所有关键工序都保持一个较高的水平。当然，友谊建筑工程项目的施工过程涉及到非常多的技术和施工难点，这也个施工人员的专业技术能力提出了更高的要求。建筑工程项目的地基对于工程项目的质量和安全具有决定性作用，如果地基不稳定，工程项目的建造质量就会受到毁灭性的影响，所以建筑工程项目的地基的建设是非常关键的。
煤矿防尘降尘技术与安全生产管理技术研究
Authors: 赵 杰
Published: March 2020

煤矿粉尘对于煤矿工人身体健康而言是一个巨大的威胁，时刻影响着煤矿工人的身体素质，尤其是井下工人，危害就更为明显。由于井下空间有限，在煤矿开采过程中产生的大量粉尘不能让井下工作人员灵巧躲避，压力过大的情况下还会发生爆炸等安全事故，对于井下矿工人员的呼吸系统造成了严重危害，需要有关技术的介入，同样也需要在安全生产管理技术上多做工作。文中我们就针对此类问题进行阐述。
新形势下天然气管网安全管理及主动防御策略
Authors: 田 甜
Published: March 2020

随着近年来物联网的建设应用和数字化水平的不断提高，企业生产管理水平和工作效率得到了极大的提升，城市燃气为越来越多城市居民的生活带来了便利，但是相应的燃气安全事故发生概率也不断增加。本篇文章在对新形势下天然气管网安全管理存在的问题分析的基础上提出了相应的对策方法。
建筑工程中施工安全管理问题和对策解析
Authors: 唐 成
Published: March 2020

在工程项目的建造施工的做成中，为了保证工程项目建造质量，必须要做好施工环节的监督管理，其中安全管理工作又是至关重要的，因为安全管理工作不仅关系到工程项目的建造质量，也直接关系到建筑工程项目的经济效益和社会效益的实现，可以说对建设项目而言是极为关键和重要的。为了加强施工项目的安全管理工作，必须全面把握工程施工的所有环节，详细分析其中潜在的安全威胁，并采取适当措施控制和管理这些潜在的危险，保证工程项目建设的顺利进行。
路桥工程建设中路基路面施工技术要点
Authors: 张 志勇
Published: March 2020

随着中国经济社会的快速发展，人们的生活和生产对于交通运输业的要求越来越高，道路交通系统的建设规模以及建造数量也越来越大，在这个过程中，高质量、高水平的道路工程项目建设是极为重要的，关系到了我国交通发展的进程。目前的建造施工技术的背景下，在道路工程项目的建设施工中，道路工程项目的建造施工质量还有待提升，特别是工程建造投入使用后，比较容易出现路基的沉降、路面的裂缝等问题，不仅影响了道路工程的正常使用，还有可能产生一系列的行车安全的隐患。因此，必须要采取积极有效的措施，对这些道路工程项目的问题进行预防和控制。
Selection of Maceration Solvent for Natural Pigment Extraction from Red Fruit (Pandanus conoideus Lam)
Authors: Purnomo Tantyo Ardy Bintoro , Kurniawan Yehezkiel Steven , Kesuma Ruth Febriana , Yuliati Dr. Leny
Published: March 2020

Red fruit (Pandanus conoideus Lam) is rich with red-orange natural pigments, such as β-carotene. In this work, the solvent selection was investigated to extract the β-carotene from the red fruit via a simple maceration technique. Three types of solvents were used in the maceration, which were distilled water, ethanol, and acetone. The obtained extracts were characterized using spectrophotometer ultraviolet-visible (UV-visible), Fourier transform infrared (FTIR) and spectrofluorometer. The different solvents gave different spectroscopic information, suggesting that the solvent selection influenced the type of the extracted compounds. Among the examined solvents, acetone was found to be the most effective one to extract the β-carotene. The presence of the β-carotene pigment in acetone extract was confirmed by the appearance of the absorption peak at 476 nm on its UV-visible spectrum, while from its FTIR spectrum, the C-H sp3 functional group of β-carotene was found at 2924 and 2854 cm-1. In addition, the emission peak of β-carotene was found at 394 and 561 nm. This study confirmed that acetone performed as a better maceration solvent for β-carotene as compared to the distilled water and ethanol, which would be strongly related to the non-polar property of the acetone.
USING COOPERATIVE LANGUAGE LEARNING IN IMPROVING THE STUDENTS’ PRONUNCIATION ACCURACY AND FLUENCY
Authors: Rochman Muhammad
Published: March 2020

This research aimed to find the improvement of the students’ Pronunciation Accuracy and Fluency by using Cooperative Language Learning  at Akademi Bahasa Asing Balikpapan at Third Semester Students in Balikpapan East Kalimantan in the 2018/2019 Academic Year. Cooperative Language Learning was used in a Classroom Action Research (CAR). The research had been conducted in two cycles, each cycle consist of four meetings. It employed Pronunciation test as instrument. A number of research subjects were 37 students in third semester. The instruments were test and observation. The research findings showed that Cooperative Language Learning could improve the students’ Pronunciation mastery from cycle I to cycle II. The students’ achievement from D-Test to cycle I was 12.50%, and after finishing cycle II the students’ achievement became 16.27%. Based on the research findings, the researcher concludes that Cooperative Language Learning gave a significant contribution in learning process of Pronunciation accuracy and fluency
FLOUTING MAXIM AND HEDGING MAXIM IN MULTICULTURAL STUDENTS INTERACTION
Authors: Amaliyasari Maya Rizki , Widiyanah Ima
Published: March 2020

IKIP Budi Utomo as a private campus in the city of Malang has a composition of students from various tribes and cultures, making it a campus with a multi-cultural society. On this campus there are five tribes that dominate, they are: Javanese, Madurese, Dayaks, Sumba Flores, and Ambon. In multicultural societies, there are often obstacles, which in turn cause conflicts, in communication. A convention is needed between the speaker and the hearers so that communication becomes effective and efficient, and is able to minimize misunderstandings. In this case the concept called the principle of cooperation (Cooperative Principles) which is intended as a rule of communication in order to run effectively and efficiently becomes relevant to be studied. The design of this study is descriptive qualitative in which data sources obtained from dialogs that arise in daily interactions both between multicultural students and students and lecturers inside and outside the class at IKIP Budi Utomo Malang. In line with the results of the research analysis, it can be concluded that, of the 476 utterances recorded as raw data from this study, there were 45 cases of maxims flouts and 12 cases of maxims hedges, which formed a certain pattern in each multicultural students.
STYLISTICS AND FIGURATIVE LANGUAGE IN SUE MONK KIDD’S THE SECRET LIFE OF BEES
Authors: Arifatin Fais Wahidatul
Published: March 2020

The goals of this study are to find out kinds of figurative language used by Sue Monk Kidd in his novel, The Secret Life of Bees, to investigate how the artistic effect and linguistic evidence achieved through figurative language and to describe how figurative language supports the theme. The research deals with the use of figurative language in a literary work, novel. Hence, this study contains the figurative language and also Sue Monk Kidd’s stylistics. The Secret Life of Bees was a New York Times bestseller list, it won 2004 book sense book of the year awards, and it was nominated for the orange broadband prize for fiction. This novel also adapted to film directed by Gina Prince-bythewood.
BASIC STRUCTURE MODULE BASED ON HYBRID LEARNING
Authors: Pusparini Indrawati , Astuti Endang Setiyo
Published: March 2020

The research aims to find out the basic structure module based on hybrid learning  needed  by the students of Ikip Budi Utomo Malang  in learning structure, especially basic structure. The current study was a need analysis which was done in the area of developing making basic structure module based on hybrid learning. The quantitative method were conducted in this research to describe the students’ needs. In collecting the data, the researcher applied questionnaire for the students as the instrument of the research. The data was taken through a questionnaire with given to 45 students who took basic structure course in the 2018-2019 academic year and analyzed quantitatively. The results of this study reveal that the students need a clear goals of basic structure modul based on hybrid learning, the  materials in line with the course outline, the assignment  and current technology for the teaching and learning process.
USING GROUP WORK TO IMPROVE STUDENTS’ READING COMPREHENSION SKILL
Authors: Ahmada Adib
Published: March 2020

The reading comprehension skill of the First Semester class of  English Education Department of Islamic  Institute of Darussalam Blokagung Banyuwangi in Academic Year 2018/2019 was low. It could be seen based on the result of preliminary study that was conducted by the researcher. Therefore, the researcher tried to use group work strategy to solve the problems. Since the study aimed to improve the students’ reading comprehension skill, the researcher used a Classroom Action Research as a research design. This research was conducted at the First Semester class of  English Education Department of Islamic Institute of Darussalam Blokagung Banyuwangi that consists of 25 students.  To measure their improvement in reading comprehension, the lecturer had determined the criteria of success. It was if the students reached the score above 70. The researcher found that group work strategy could improve students’ reading skill. The students reading skill increased from 24%, 64%, to 92% (preliminary study, the first cycle and the second cycle).
Selected Sex Related Differences in Pathophysiology of Cardiovascular System
Authors: KITTNAR O.
Published: March 2020

The annual incidence of cardiovascular diseases is age-dependently increasing both in men and women, however, the prevalence is higher in men until midlife. The higher incidence of cardiovascular disease in men than in women of similar age, and the menopause-associated increase in cardiovascular disease in women, has led to speculation that gender-related differences in sex hormones might have a key role in the development and evolution of cardiovascular disease. There are several suggested pathways in which gender and sex hormones can affect human cardiovascular system to produce original sexually different pathophysiology between women and men. Sex steroid hormones and their receptors are critical determinants of cardiovascular gender differences. Also arterial blood pressure is typically lower in women than in men what could be explained particularly by greater synthesis of nitric oxide (NO) in women. Female cardiomyocytes have a greater survival advantage when challenged with oxidative stress, suggesting that female hormones may play an important role in antioxidative protection of myocardium. It was also demonstrated in animal models that combination of XX chromosomes versus an XY chromosomes enhances sex differences in higher HDL cholesterol. Women were found to have reduced sympathetic activity (reflected by lower total peripheral resistance) and pulmonary artery pressure and enhanced parasympathetic activity relative to men. Similarly, men were found to have higher plasma norepinephrine levels than women. Regarding differences between the sexes in electrophysiology of the heart, two principle mechanisms have been proposed to explain them: hormonal effects on the expression or function of ion channels or, conversely, differences in autonomic tone. To improve diagnosis and treatment of cardiovascular diseases, greater focus on understanding the molecular and cellular physiology of the sex steroid hormones and their receptors in the cardiovascular system will be required.
Implementation of Fuzzy Logic Controller for Wall Following and Obstacle Avoiding Robot
Authors: Soetedjo Aryuanto , Ashari M. Ibrahim , Septian Cosnas Eric
Published: March 2020

This paper presents the development of wall following and obstacle avoiding robot using a Fuzzy Logic Controller. The ultrasonic sensors are employed to measure the distances between robot and the wall, and between the robot and the obstacle. A low cost Raspberry Pi camera is employed to measure the left/right distance between the robot and the obstacle. The Fuzzy Logic Controller is employed to steer the mobile robot to follow the wall and avoid the obstacle according to the multi sensor inputs. The outputs of Fuzzy Logic Controller are the speeds of left motor and right motor. The experimental results show that the developed mobile robot could be controlled properly to follow the different wall positions and avoid the different obstacle positions with the high successful rate of 83.33%.
Sliding Modes Strategy Implementation for Controlling Nutrition in Hydroponics Based IoT
Authors: Sukmana Septian Enggar , Winarsih Nurul Anisa Sri , Akbar Akmaludin
Published: March 2020

To reduce unconsistenly of nutrition sensor data, an analysis which consists of mathemathical model and new control technique is required. In this paper, a simulation of smart garden is performed to simulate a smart green campus. However, the problem appears in this activity, the data form sensor is not consistent and it may harm the plant because sometime the plant may get a much nutrition and another time the plant will get less nutrition. Our propose is on the sensor circuit, we use additional circuit to our TDS meter so the data is normalized using this circuit.
Nilai-Nilai Pendidikan Kesehatan Reproduksi pada Tradisi Karia di Masyarakat Muna
Authors: Lestariwati Lestariwati , Suryati Nurmin , Akifah Akifah
Published: March 2020

Karia merupakan salah satu tradisi daur hidup masyarakat Muna yang bernuansa ritual. Tradisi ini menjadi menjadi puncak kangkilo bagi anak perempuan yang telah memasuki usia remaja dan siap berumah tangga. Menikah itu bukanlah perkara yang mudah tetapi harus memiliki kesiapan yaitu kesiapan fisik, mental/psikologis, sosial/ekonomi. Banyak kasus terjadi di masa sekarang yang mempengaruhi kesehatan reproduksi salahs atunya adalah hubungan seks pranikah yang berujung pada MBA (married by accident). Penelitian ini bertujuan untuk mengetahui nilai-nilai pendidikan kesehatan reproduksi yang terdapat pada tradisi karia. Metodologi penelitian bersifat deskriptif kualitatif dan kuantitatif. Hasil penelitian menemukan bahwa terdapat 2 (dua) nilai dalam tradisi karia yang berhubungan dengan pendidikan kesehatan reproduksi yaitu nilai filosofis dan nilai pendidikan. Tetapi pada masa sekarang dalam tradisi karia pendidikan kesehatan reproduksi tersebut sudah mengalami pergeseran.
Rebu: Tradisi Pantangan bagi Suku Karo
Authors: Ginting Sardis Br , Niampe La , Topo Jers La Ode
Published: March 2020

Tujuan penelitian ini adalah untuk mendeskripsikan dan menganalisis faktor penyebab pergeseran tradisi rebu pada Suku Karo di Kota Kendari. Lokasi penelitian adalah Kota Kendari. Metode yang digunakan dalam penelitian ini adalah metode pendekatan etnografi. Teori yang digunakan sebagai alat analisis dan dasar pembahasan masalah dalam penelitian ini adalah teori dekonstruksi. Teknik pengumpulan data yang digunakan peneliti adalah observasi, wawancara mendalam, dan dokumentasi. Teknik analisa data adalah dengan menggunakan analisa deskriptif kualitatif dengan pendekatan etnografi. Hasil penelitian menunjukkan bahwa faktor penyebab pergeseran tradisi rebu terdapat dua faktor pertama, faktor dari dalam masyarakat yaitu kurangnya pemahaman terhadap tradisi rebu, kurangnya sosialisasi dalam masyarakat, dan hilangnya nilai-nilai budaya. Kedua, faktor dari luar masyarakat yaitu arus modernisasi dan globalisasi, lingkungan, perkawinan campur, ekonomi dan faktor politik.
Pembangunan Infrastruktur Pedesaan Berbasis Kearifan Lokal
Authors: Herlan Herlan , Taena La , Aso La
Published: March 2020

Tujuan penelitian ini adalah untuk mengidentifikasi pelaksanaan pembangunan pedesaan (infrastruktur) berbasis kearifan lokal serta dampaknya di Desa Lalonggasumeeto, Kecamatan Lalonggasumeeto, Kabupaten Konawe. Jenis data dalam penelitian ini adalah data kualitatif yaitu data yang berdasarkan atas segala informasi dari keterangan yang diberikan oleh informan kunci dan informan pokok. Hasil penelitian ini menunjukkan bahwa; (1) pelaksanaan pembangunan desa berbasis kearifan lokal di Desa Lalong-gaasumeeto Kecamatan Lalonggaasumeeto Kabupaten Konawe dilaksanakan berdasarkan Budaya samaturu medulu ronga mepokoo’aso (budaya bersatu, suka tolong menolong dan saling membantu). Masyarakat suku Tolaki dalam menghadapi setiap permasalahan sosial dan pemerintahan baik itu berupa upacara adat, pesta pernikahan, kematian maupun dalam melaksanakan peran dan fungsinya sebagai warga negara, selalu bersatu, bekerjasama, saling tolong menolong dan bantu-membantu, dan (2) dampak pembangunan pedesaan berbasis kearifan lokal di Desa Lalonggasumeeto, Kecamatan Lalonggasumeeto, Kabupaten Konawe memiliki peluang untuk dihidupkan dan ditumbuhkembangkan kembali sehingga dapat mengatur kehidupan dan menjadi pranata, norma dan aturan yang diberikan dengan pengelolaan suber daya lingkungan.
Pedagogía del lenguaje en Colombia: un estado del arte
Authors: Cardona Diego Fabian
Published: March 2020

Este documento presenta los antecedentes investigativos del proyecto Una pedagogía del lenguaje y la comunicación en las prácticas culturales y comunicativas de los jóvenes de los colegios públicos de Bogotá, adscrito al Doctorado en Educación de la Universidad Distrital Francisco José de Caldas. Dicha investigación asume como núcleo temático la relación que existe entre la formación en lenguaje, las prácticas comunicativas de los jóvenes y las matrices culturales que subyacen a estas prácticas. La revisión de antecedentes que se presenta enseguida, ha sido elaborada a partir del análisis y la revisión documental de estudios recientes sobre el tema de la investigación, y gira en torno a la práctica pedagógica del lenguaje en Colombia, asumida como el escenario cotidiano en el que interactúan las formas de ser, actuar y pensar de maestros y estudiantes en la clase de Lengua Castellana. Para ello, la exposición de hallazgos inicia con un recorrido por la práctica pedagógica del lenguaje en Colombia, seguido por una caracterización de dicha práctica en otros países de América Latina y en Europa. Además, en los apartados tres y cuatro se exponen los elementos de la política educativa colombiana y la relación entre comunicación, cultura y pedagogía que propone el enfoque sociocultural para la enseñanza del lenguaje. Finalmente se plantea una reflexión de cierre sobre los hallazgos de la revisión de antecedentes.
Valoración de la capacidad funcional y actividades de la vida diaria en adultos mayores institucionalizados
Authors: Criollo Wilmer Arley
Published: March 2020

Introducción: La evaluación funcional del adulto mayor es uno de los principales ejes de la valoración geriátrica integral, pues resulta esencial para orientar el trabajo de profesionales relacionados con las personas mayores. Objetivo: Valorar la capacidad funcional y las actividades de la vida diaria, en población adulta mayor vinculada a dos instituciones geriátricas de la ciudad de Cali. Materiales y Métodos: Estudio descriptivo de corte transversal, realizado en dos instituciones geriátricas a 87 adultos mayores de 60 años. Se realizó un muestreo a conveniencia, previo consentimiento informado, considerando criterios de inclusión y exclusión. Se midió la capacidad funcional a través de las medidas basadas en la ejecución y las actividades de la vida diaria mediante la escala de Barthel. Resultados: Los participantes en este estudio en su mayoría son mujeres con un 56.3 %, predomino el nivel educativo primaria con un 41.4 %, el 82.7 % presenta alta probabilidad de caidas, el 66.6 % muestran ser independientes, seguido de un 21 % que presentan dependencia moderada. Conclusión: La mayor parte de la población participante en este estudio es independiente, tan solo el 34 % presenta dependencia leve a moderada, sin embargo, es un porcentaje considerable que requiere la toma de medidas tendientes a mejorar el grado de independencia en las actividades de la vida diaria de esta población objeto de estudio.
Review on the Development, Control Method and Application Prospect of Brake-by-Wire Actuator
Authors: Gong Xiaoxiang , Ge Weiguo , Yan Juan , Zhang Yiwei , Gongye Xiangyu
Published: March 2020

This paper reviews and summarizes the development, key technologies, and application of brake-by-wire (BBW) actuators. BBW is the technology orientation of future vehicle brake system. The main feature of BBW is to replace some of the mechanical and hydraulic components of traditional brake system with electronic control components, and use cables and wires to transmit energy and signals. BBW actuators have outstanding advantages, such as fast response, accurate control, and compact structure. They are easy to integrate with active safety functions and they are easily matched with the regenerative braking systems of electric vehicle. First, this paper summarizes the classification, characteristics, performance, and architecture of BBW actuators. Subsequently, the braking process regulation of vehicle is considered to be the main target, which is summarized from two aspects of actuator regulation and braking force distribution. The state estimation algorithm and control algorithm applied to these actuators are summarized and analyzed, and the development trend, challenges, and schemes of the braking force distribution are proposed. The development and research trend of braking force match strategies between the regenerative brake system and BBW system are also analyzed and summarized. The further electrification and intelligence of vehicle demand BBW’s braking force control method and distribution method must have higher control accuracy, stronger robustness, and wider adaptability, and the effects on braking comfort and handling stability must be further discussed.
Identification Method of Geometric Deviations for Multi-Tasking Machine Tools Considering the Squareness of Translational Axes
Authors: Yao Yan , Nishizawa Keisuke , Kato Noriyuki , Tsutsumi Masaomi , Nakamoto Keiichi
Published: March 2020

Some methods to identify geometric deviations of five-axis machining centers have been proposed until now. However, they are not suitable for multi-tasking machine tools because of the different configuration and the mutual motion of the axes. Therefore, in this paper, an identification method for multi-tasking machine tools with a swivel tool spindle head in a horizontal position is described. Firstly, geometric deviations are illustrated and the mathematical model considering the squareness of translational axes is established according to the simultaneous three-axis control movements. The influences of mounting errors of the measuring instrument on circular trajectories are investigated and the measurements for the B axis in the Cartesian coordinate system and the measurements for the C axis in a cylindrical coordinate system are proposed. Then, based on the simulation results, formulae are derived from the eccentricities of the circular trajectories. It is found that six measurements are required to identify geometric deviations, which should be performed separately in the B axis X-direction, in B axis Y-direction, in C axis axial direction, and three times in C axis radial direction. Finally, a numerical experiment is conducted and identified results successfully match the geometric deviations. Therefore, the proposed method is proved to identify geometric deviations effectively for multi-tasking machine tools.
Numerical Evaluation of Dynamic Responses of Steel Frame Structures with Different Types of Haunch Connection Under Blast Load
Authors: Yussof Mustafasanie M. , Silalahi Jordan Halomoan , Kamarudin Mohd Khairul , Chen Pei-Shan , Parke Gerard A. R.
Published: March 2020

This research is aimed at investigating the dynamic behaviour of, and to analyse the dynamic response and dynamic performance of steel frames strengthened with welded haunches subjected to a typical hydrocarbon blast loading. The structural dynamic analysis was carried out incorporating the selected blast load, the validated 3D model of the structures with different welded haunch configurations, steel dynamic material properties, and non-linear dynamic analysis of multiple degree of freedom (MDOF) structural systems. The dynamic responses and effectiveness of the reinforced connections were examined using ABAQUS finite element software. Results showed that the presence of the welded haunch reinforcement decreased the maximum frame ductility ratio. Based on the evaluation of the results, the haunch reinforcements strengthened the selected steel frame and improved the dynamic performance compared to the frame with unreinforced connections under blast loading, and the biggest haunch configuration is the “best” type.
Epicardial TGFβ and BMP Signaling in Cardiac Regeneration: What Lesson Can We Learn from the Developing Heart?
Authors: Dronkers Esther , Wauters Manon M. M. , Goumans Marie José , Smits Anke M.
Published: March 2020

The epicardium, the outer layer of the heart, has been of interest in cardiac research due to its vital role in the developing and diseased heart. During development, epicardial cells are active and supply cells and paracrine cues to the myocardium. In the injured adult heart, the epicardium is re-activated and recapitulates embryonic behavior that is essential for a proper repair response. Two indispensable processes for epicardial contribution to heart tissue formation are epithelial to mesenchymal transition (EMT), and tissue invasion. One of the key groups of cytokines regulating both EMT and invasion is the transforming growth factor β (TGFβ) family, including TGFβ and Bone Morphogenetic Protein (BMP). Abundant research has been performed to understand the role of TGFβ family signaling in the developing epicardium. However, less is known about signaling in the adult epicardium. This review provides an overview of the current knowledge on the role of TGFβ in epicardial behavior both in the development and in the repair of the heart. We aim to describe the presence of involved ligands and receptors to establish if and when signaling can occur. Finally, we discuss potential targets to improve the epicardial contribution to cardiac repair as a starting point for future investigation.
Hydroxylamine Analogue of Agmatine: Magic Bullet for Arginine Decarboxylase
Authors: Hyvönen Mervi T. , Keinänen Tuomo A. , Nuraeva Gulgina K. , Yanvarev Dmitry V. , Khomutov Maxim , Khurs Elena N. , Kochetkov Sergey N. , Vepsäläinen Jouko , Zhgun Alexander A. , Khomutov Alex R.
Published: March 2020

The biogenic polyamines, spermine, spermidine (Spd) and putrescine (Put) are present at micro-millimolar concentrations in eukaryotic and prokaryotic cells (many prokaryotes have no spermine), participating in the regulation of cellular proliferation and differentiation. In mammalian cells Put is formed exclusively from L-ornithine by ornithine decarboxylase (ODC) and many potent ODC inhibitors are known. In bacteria, plants, and fungi Put is synthesized also from agmatine, which is formed from L-arginine by arginine decarboxylase (ADC). Here we demonstrate that the isosteric hydroxylamine analogue of agmatine (AO-Agm) is a new and very potent (IC50 3•10−8 M) inhibitor of E. coli ADC. It was almost two orders of magnitude less potent towards E. coli ODC. AO-Agm decreased polyamine pools and inhibited the growth of DU145 prostate cancer cells only at high concentration (1 mM). Growth inhibitory analysis of the Acremonium chrysogenum demonstrated that the wild type (WT) strain synthesized Put only from L-ornithine, while the cephalosporin C high-yielding strain, in which the polyamine pool is increased, could use both ODC and ADC to produce Put. Thus, AO-Agm is an important addition to the set of existing inhibitors of the enzymes of polyamine biosynthesis, and an important instrument for investigating polyamine biochemistry.
Hemocompatibility of Carbon Nanostructures
Authors: Fedel Mariangela
Published: March 2020

Carbon nanostructures (CNs), such as carbon nanotubes, fullerenes, carbon dots, nanodiamonds as well as graphene and its derivatives present a tremendous potential for various biomedical applications, ranging from sensing to drug delivery and gene therapy, biomedical imaging and tissue engineering. Since most of these applications encompass blood contact or intravenous injection, hemocompatibility is a critical aspect that must be carefully considered to take advantage of CN exceptional characteristics while allowing their safe use. This review discusses the hemocompatibility of different classes of CNs with the purpose of providing biomaterial scientists with a comprehensive vision of the interactions between CNs and blood components. The various complex mechanisms involved in blood compatibility, including coagulation, hemolysis, as well as the activation of complement, platelets, and leukocytes will be considered. Special attention will be paid to the role of CN size, structure, and surface properties in the formation of the protein corona and in the processes that drive blood response. The aim of this review is to emphasize the importance of hemocompatibility for CNs intended for biomedical applications and to provide some valuable insights for the development of new generation particles with improved performance and safety in the physiological environment.
Studies on the Drug Loading and Release Profiles of Degradable Chitosan-Based Multilayer Films for Anticancer Treatment
Authors: Sun Hyeongdeok , Choi Daheui , Heo Jiwoong , Jung Se Yong , Hong Jinkee
Published: March 2020

This study demonstrates the possibility of developing a rapidly degradable chitosan-based multilayer film for controlled drug release. The chitosan (CHI)-based multilayer nanofilms were prepared with three different types of anions, hyaluronic acid (HA), alginic acid (ALG) and tannic acid (TA). Taking advantage of the Layer-by-Layer (LBL) assembly, each multilayer film has different morphology, porosity and thickness depending on their ionic density, molecular structure and the polymer functionality of the building blocks. We loaded drug models such as doxorubicin hydrochloride (DOX), fluorescein isothiocyanate (FITC) and ovalbumin (Ova) into multilayer films and analyzed the drug loading and release profiles in phosphate-buffered saline (PBS) buffer with the same osmolarity and temperature as the human body. Despite the rapid degradation of the multilayer film in a high pH and salt solution, the drug release profile can be controlled by increasing the functional group density, which results in interaction with the drug. In particular, the abundant carboxylate groups in the CHI/HA film increased the loading amount of DOX and decreased rapid drug release. The TA interaction with DOX via electrostatic interaction, hydrogen bonding and hydrophobic interaction showed a sustained drug release profile. These results serve as principles for fabricating a tailored multilayer film for drug delivery application.
VE1 Immunohistochemistry Improves the Limit of Genotyping for Detecting BRAFV600E Mutation in Papillary Thyroid Cancer
Authors: Choden Sonam , Keelawat Somboon , Jung Chan Kwon , Bychkov Andrey
Published: March 2020

Detection of BRAFV600E is useful for making diagnosis and risk stratification of papillary thyroid carcinoma (PTC). Molecular testing, however, is not always available for routine clinical use. To assess the clinical utility and reliability of VE1 immunohistochemistry (IHC) for detecting BRAFV600E mutation in PTC, VE1 IHC was performed on the tissue microarrays of 514 patients with PTC and was compared with Sanger sequencing results. Of 514 PTC cases, 433 (84.2%) were positive for VE1 expression. Among 6 discordant cases between VE1 IHC and Sanger sequencing, 3 initial VE1-false negative cases turned out to be true false negative on repeat testing, and 3 VE1-false positive cases showed BRAFV600E mutation using digital PCR analysis. PTCs with low variant allele fraction were positive for VE1 IHC but were not detected using sequencing. VE1 IHC showed 99.3% sensitivity, 100% specificity, 100% positive predictive value, and 96.4% negative predictive value. The BRAFV600E mutation was significantly associated with older age, multifocality, extrathyroidal extension, lymph node metastasis, and advanced tumor stage. In conclusion, VE1 IHC is a reliable method for detecting BRAFV600E mutation in PTC specimens.
mTOR and STAT3 Pathway Hyper-Activation is Associated with Elevated Interleukin-6 Levels in Patients with Shwachman-Diamond Syndrome: Further Evidence of Lymphoid Lineage Impairment
Authors: Vella Antonio , D’Aversa Elisabetta , Api Martina , Breveglieri Giulia , Allegri Marisole , Giacomazzi Alice , Marinelli Busilacchi Elena , Fabrizzi Benedetta , Cestari Tiziana , Sorio Claudio , Bedini Gloria , D’Amico Giovanna , Bronte Vincenzo , Poloni Antonella , Benedetti Antonio , Bovo Chiara , Corey Seth , Borgatti Monica , Cipolli Marco , Bezzerri Valentino
Published: March 2020

Shwachman–Diamond syndrome (SDS) is a rare inherited bone marrow failure syndrome, resulting in neutropenia and a risk of myeloid neoplasia. A mutation in a ribosome maturation factor accounts for almost all of the cases. Lymphoid involvement in SDS has not been well characterized. We recently reported that lymphocyte subpopulations are reduced in SDS patients. We have also shown that the mTOR-STAT3 pathway is hyper-activated in SDS myeloid cell populations. Here we show that mTOR-STAT3 signaling is markedly upregulated in the lymphoid compartment of SDS patients. Furthermore, our data reveal elevated IL-6 levels in cellular supernatants obtained from lymphoblasts, bone marrow mononuclear and mesenchymal stromal cells, and plasma samples obtained from a cohort of 10 patients. Of note, everolimus-mediated inhibition of mTOR signaling is associated with basal state of phosphorylated STAT3. Finally, inhibition of mTOR-STAT3 pathway activation leads to normalization of IL-6 expression in SDS cells. Altogether, our data strengthen the hypothesis that SDS affects both lymphoid and myeloid blood compartment and suggest everolimus as a potential therapeutic agent to reduce excessive mTOR-STAT3 activation in SDS.
Glutaminases as a Novel Target for SDHB-Associated Pheochromocytomas/Paragangliomas
Authors: Sarkadi Balazs , Meszaros Katalin , Krencz Ildiko , Canu Letizia , Krokker Lilla , Zakarias Sara , Barna Gabor , Sebestyen Anna , Papay Judit , Hujber Zoltan , Butz Henriett , Darvasi Otto , Igaz Peter , Doczi Judit , Luconi Michaela , Chinopoulos Christos , Patocs Attila
Published: March 2020

Pheochromocytoma/paragangliomas (Pheo/PGL) are rare endocrine cancers with strong genetic background. Mutations in the SDHB subunit of succinate dehydrogenase (SDH) predispose patients to malignant disease with limited therapeutic options and poor prognosis. Using a host of cellular and molecular biology techniques in 2D and 3D cell culture formats we show that SDH inhibition had cell line specific biological and biochemical consequences. Based on our studies performed on PC12 (rat chromaffin cell line), Hela (human cervix epithelial cell line), and H295R (human adrenocortical cell line) cells, we demonstrated that chromaffin cells were not affected negatively by the inhibition of SDH either by siRNA directed against SDHB or treatment with SDH inhibitors (itaconate and atpenin A5). Cell viability and intracellular metabolite measurements pointed to the cell line specific consequences of SDH impairment and to the importance of glutamate metabolism in chromaffin cells. A significant increase in glutaminase-1 (GLS-1) expression after SDH impairment was observed in PC12 cells. GLS-1 inhibitor BPTES was capable of significantly decreasing proliferation of SDH impaired PC12 cells. Glutaminase-1 and SDHB expressions were tested in 35 Pheo/PGL tumor tissues. Expression of GLS1 was higher in the SDHB low expressed group compared to SDHB high expressed tumors. Our data suggest that the SDH-associated malignant potential of Pheo/PGL is strongly dependent on GLS-1 expression and glutaminases may be novel targets for therapy.
FDG-PET Imaging for Hodgkin and Diffuse Large B-Cell Lymphoma—An Updated Overview
Authors: Voltin Conrad-Amadeus , Mettler Jasmin , Grosse Jirka , Dietlein Markus , Baues Christian , Schmitz Christine , Borchmann Peter , Kobe Carsten , Hellwig Dirk
Published: March 2020

Since the mid-1990s, 18F-fluorodeoxglucose (FDG)-positron emission tomography (PET) in combination with computed tomography has come to play a prominent role in the management of malignant lymphomas. One of the first PET applications in oncology was the detection of lymphoma manifestations at staging, where it has shown high sensitivity. Nowadays, this imaging modality is also used during treatment to evaluate the individual chemosensitivity and adapt further therapy accordingly. If the end-of-treatment PET is negative, irradiation in advanced-stage Hodgkin lymphoma patients can be safely omitted after highly effective chemotherapy. Thus far, lymphoma response assessment has mainly been performed using visual criteria, such as the Deauville five-point scale, which became the international standard in 2014. However, novel measures such as metabolic tumor volume or total lesion glycolysis have recently been recognized by several working groups and may further increase the diagnostic and prognostic value of FDG-PET in the future.
The Application of Deep Learning in Cancer Prognosis Prediction
Authors: Zhu Wan , Xie Longxiang , Han Jianye , Guo Xiangqian
Published: March 2020

Deep learning has been applied to many areas in health care, including imaging diagnosis, digital pathology, prediction of hospital admission, drug design, classification of cancer and stromal cells, doctor assistance, etc. Cancer prognosis is to estimate the fate of cancer, probabilities of cancer recurrence and progression, and to provide survival estimation to the patients. The accuracy of cancer prognosis prediction will greatly benefit clinical management of cancer patients. The improvement of biomedical translational research and the application of advanced statistical analysis and machine learning methods are the driving forces to improve cancer prognosis prediction. Recent years, there is a significant increase of computational power and rapid advancement in the technology of artificial intelligence, particularly in deep learning. In addition, the cost reduction in large scale next-generation sequencing, and the availability of such data through open source databases (e.g., TCGA and GEO databases) offer us opportunities to possibly build more powerful and accurate models to predict cancer prognosis more accurately. In this review, we reviewed the most recent published works that used deep learning to build models for cancer prognosis prediction. Deep learning has been suggested to be a more generic model, requires less data engineering, and achieves more accurate prediction when working with large amounts of data. The application of deep learning in cancer prognosis has been shown to be equivalent or better than current approaches, such as Cox-PH. With the burst of multi-omics data, including genomics data, transcriptomics data and clinical information in cancer studies, we believe that deep learning would potentially improve cancer prognosis.
Prognostic Value of Lymph Node-To-Primary Tumor Standardized Uptake Value Ratio in Esophageal Squamous Cell Carcinoma Treated with Definitive Chemoradiotherapy
Authors: Lin Chia-Hsin , Hung Tsung-Min , Chang Yu-Chuan , Hsieh Chia-Hsun , Shih Ming-Chieh , Huang Shih-Ming , Yang Chan-Keng , Chang Ching-Fu , Chan Sheng-Chieh , Yap Wing-Keen
Published: March 2020

We aimed to investigate the prognostic value of the relative maximum standardized uptake value (SUV) of metastatic lymph node (LN) compared with that of primary tumor (SUVLN/SUVTumor) based on a pretreatment [18F]-FDG PET/CT scan in patients with clinically node-positive esophageal squamous cell carcinoma (cN+ ESCC) treated with definitive chemoradiotherapy (dCRT). We retrospectively evaluated cN+ ESCC patients who underwent a PET/CT scan before dCRT. Time-dependent receiver operating characteristics analysis was performed to identify the optimal cutoff value for SUVLN/SUVTumor. Prognostic influences of SUVLN/SUVTumor on distant metastasis-free survival (DMFS) and overall survival (OS) were evaluated using the Kaplan–Meier method and log-rank test for univariate analysis and Cox’s proportional hazards regression model for multivariate analysis. We identified 112 patients with newly diagnosed cN+ ESCC. After a median follow-up of 32.0 months, 50 (44.6%) patients had distant failure and 84 (75.0%) patients died. Patients with high SUVLN/SUVTumor (≥ 0.39) experienced worse outcomes than low SUVLN/SUVTumor (< 0.39) (two-year DMFS: 26% vs. 70%, p < 0.001; two-year OS: 21% vs. 48%, p = 0.001). Multivariate analysis showed that SUVLN/SUVTumor was an independent prognostic factor for both DMFS (adjusted HR 2.24, 95% CI 1.34–3.75, p = 0.002) and OS (adjusted HR 1.61, 95% CI 1.03–2.53, p = 0.037). Pretreatment of SUVLN/SUVTumor is a simple and useful marker for prognosticating DMFS and OS in cN+ ESCC patients treated with dCRT, which may help in tailoring treatment and designing future clinical trials.