bluuebunny/crossref_metadata_2025 huggingface dataset:
The protective effect of hydroalcoholic extract of Ephedra pachyclada leaves on ovarian damage induced by cyclophosphamide in rat: An experimental study
Authors: Abedi Hassanali , Nemati Mahnaz , Ebrahimi Bahare , Dehghani Maryam , Mikaeiliagah Elmira , Abdollahzadeh Pegah , Ghanaatpishe Aref , Jahromi Nazanin Shafiee , Jahromi Hossein Kargar
Published: September 2023

Background: Cyclophosphamide (CP) is an anticancer drug that acts as an alkylation agent after metabolism in the liver. CP has toxic effects on the body’s cells, especially the reproductive system’s function, and causes infertility. Moreover, medicinal plants have few side effects and are psychologically acceptable to patients.
Objective: This study aimed to investigate the impact of Ephedra pachyclada hydroalcoholic extract (EPHE) on ovarian tissue and hypothalamic-pituitary-gonadal axis in rats treated with CP.
Materials and Methods: In this experimental study, 48 adult female Wistar rats (180-200 gr, 9-10 wk) were randomly assigned to 6 experimental groups (n = 8/each): (a) control; (b) sham; (c) CP; (d) CP+250 mg/kg EPHE; (e) CP+500 mg/kg EPHE; (f) CP+1000 mg/kg EPHE. On the 29th day of the experiment, serum was collected; serum concentration of the luteinizing hormone, follicle-stimulating hormone, estrogen, progesterone, and antioxidant activity were measured. The number of ovarian follicles were also counted.
Results: In the CP groups, serum concentrations of follicle-stimulating hormone and luteinizing hormone significantly increased, and estrogen and progesterone significantly decreased (p ≤ 0.05). EPHE significantly compensated for the complications caused by CP and 1000 mg/kg had the greatest effect. Antioxidant reduction by CP was significantly enhanced by EPHE, especially at higher doses (p ≤ 0.05). The number of primordial, primary, secondary, and Graafian follicles showed a significant decrease in CP groups and EPHE groups showed a significant increase compared to the CP. EPHE showed that the concentration of 1000 mg/kg was more effective than other doses (p ≤ 0.05).
Conclusion: In addition to proving the effect of EPHE on the hypothalamic-pituitary-gonadal axis, our investigation showed antioxidant properties, which can be an effective factor in CP-treated rats.
Key words: Ephedra, Cyclophosphamide, Ovary, Follicles, Hydroalcoholic extract.
The Management And Evaluation of the Diagnostic-Therapeutic Pathway of Patients with Chronic Obstructive Diseases: A Retrospective Survey of the Italian Population
Authors: Scaramozzino Marco Umberto , Guido Dr. Levi , Giovanni Dr. Sapone , Ubaldo Plastina Romeo , Mariacarmela Dr.sa Nucara
Published: September 2023

The study is an independent retrospective cohort study, the data used were collected after obtaining informed consent from patients and were conducted anonymously online. The study was conducted on a heterogeneous population of patients with chronic obstructive respiratory disease (200 survey responses) who were attending the outpatient pneumology clinic "La Madonnina" based in Reggio Calabria, Italy from May 2021 until May 2022. The survey included ten multiple-choice questions with a single answer allowed and in some questions also the possibility of writing comments, carried out through the Survey Monkey digital platform. The objectives of the study are:
1. To identify the prevalence of symptoms perceived by patients with chronic obstructive pulmonary disease (COPD and asthma),
2. The role of the Respiratory Medicine Specialist and General Practitioner in the management of these diseases.
3. The emerging figure of self-management of these diseases is indirectly indicative of a high degree of depression in the population with these diseases, which is still poorly known and addressed by Italian general practitioners.
The extrapolated data from the online survey, indicate that there is to date a prevalence of Asthma versus COPD, confirming that the prevalent common symptom is dyspnea, also clarifies that the management of the diagnostic and therapeutic pathway of chronic respiratory diseases is of specialist relevance; the prescribed therapies act mainly on the symptom dyspnea (25.36%).
Isolated Zvs-Pwm DC-DC Converter Based on the Variable Capacitor Technique
Authors: Caús Angélica P. , Barbi Ivo
Published: September 2023

This paper introduces a new static power conversion principle, based on the variable capacitance of a capacitor arrangement. As an example of the proposed technique, an isolated ZVS-PWM dc-dc converter topology is proposed. Circuit operation and theoretical analysis, with emphasis on the soft-commutation process, are included in the paper. To validate the theoretical analysis and verify the operation of the converter, a proof-of-concept experimental prototype with 960W power rating, 400 V input voltage, 48 V output voltage and 100 kHz switching frequency was designed, constructed and tested in a laboratory. An additional attribute of the proposed technique is the reduction of the voltage across the power semiconductors to two-thirds of the dc bus voltage, when the duty cycle is equal to 0.5. The proposed technique can be extended and used to generate several other topologies of isolated and nonisolated dc-dc converters.
ANALYSIS OF CONSUMER BEHAVIOUR IN THE EUROPEAN POULTRY MEAT MARKET
Authors: Vida Viktória , Szakály Zoltán
Published: September 2023

This research has also confirmed that poultry meat is currently in its golden age, not only in our country but also globally. The beneficial physiological effects of poultry meat, its nutritional value (high protein content), and its role in modern nutrition and diets have made it the most popular and 'fashionable' meat product of our time. Healthiness as a megatrend has favoured the consumption of poultry meat, which has been consumed for decades, and is reflected in the growth in production, trade and consumption. The trend of environmental awareness has also pushed the meat market towards the consumption of poultry meat as it is one of the least environmentally intensive compared to other meat types. Poultry meat is the second most commonly consumed meat in the EU, but in some European countries, it has taken over the overall lead (e.g. Hungary, Cyprus, and the UK). Poultry is not only preferred for its healthiness and low environmental impact, it is also an easy, versatile, quick-to-prepare, cheap source of protein. These advantages are expected to lead to further growth in the future in terms of production, trade and consumption, China, the US, the EU and Brazil dominate the poultry sector.
Construção e validação de conteúdo educacional tecnológico
Authors: Werneck Luciana Pereira Pacheco , Oliveira Ivanete da Rosa Silva de , Rodrigues Denise Celeste Godoy de Andrade
Published: September 2023

Introdução: O surgimento de novas Tecnologias de Informação e Comunicação (TIC) tem contribuído para o desenvolvimento da sociedade em vários aspectos, dentre eles, a atualização e formação profissional.  Por meio de computadores e dispositivos móveis, o acesso às informações encurta distâncias antes não permitidas sem a tecnologia. Com essa evolução, as pessoas têm buscado se adaptar aos mais diversos modelos oferecidos, gerando um aumento no acesso a esses dispositivos. Objetivo: Este artigo é parte de uma pesquisa realizada em um curso de Mestrado Profissional da área de Ensino no Sul Fluminense, que objetiva propor a capacitação docente para atuar com estudantes do ensino superior com Transtorno de Déficit de Atenção e Hiperatividade (TDAH) por meio de Podcast. Portanto, o presente estudo apresenta resultados parciais da elaboração e validação do produto educacional desenvolvido à partir de pesquisa. Metodologia: Trata-se de um estudo metodológico cuja às etapas obedecem à sequência de estrutura conceitual; revisão narrativa, construção das perguntas e escala de respostas; estruturação do instrumento e validação de conteúdo por especialistas. Foram adotadas como ferramentas metodológicas a Escala de Likert e o Instrumento de Validação de Conteúdo Educativo (IVCE). Resultados: Os resultados apresentaram uma média das respostas dos especialistas, acima de 3,6 de nível de concordância para o produto em sua análise geral. Conclusão: O IVCE se mostrou como uma potente ferramenta de análise do produto educacional, por se adequar aos mais diversos modelos de conteúdos educativos demonstrando sua flexibilidade na divisão dos fatores a serem avaliados.
Digital transformation of Higher Education Institutions
Authors: Jacociunas Tomás , Verschoore Jorge Renato , Monticelli Jefferson Marlon
Published: September 2023

Introduction: Digital Transformation (DT) was accelerated by the COVID-19 pandemic, since it has intensified the use of digital platforms as a way to avoid crowding of people in physical environments. DT is present in different markets as more population groups have access to the internet. It has been changing consumer preferences and, consequently, consumer decision-making. One of the markets is that of Higher Education Institutions (HEIs), which adopt strategic changes to continue reaching the audiences that emerge from online platforms. Objective: We applied the Resource-Based View to identify the strategic resources that Brazilian HEIs have used to promote their digital transformation to the e-learning format. Methodology: Therefore, we proposed a framework using the Design Science Research method. To validate the framework, three stages of interviews were carried out with individuals directly involved with DT, HEI professors, HEI managers and EdTech’s professionals. Results/Conclusion: Our results validated a framework with eight attributes: Effectiveness of Courses, Quality Educational Programs, Training of Professors for e-learning, Appropriate Management System, Active Sales Process, Engagement of Professionals, Technology, Agile Development, and Entrepreneurial Culture.
Desafios para a permanência no Ensino Superior
Authors: Lima Francisco José de , Oliveira Joyce Pereira
Published: September 2023

Introdução/Objetivo: O objetivo deste estudo é discutir sobre aspectos que dificultam o desenvolvimento e a permanência de alunos ingressantes em um curso superior. Metodologia: Ancorada em pressupostos da abordagem qualitativa, a pesquisa tomou o estudo de caso como estratégia de investigação. Resultados: Os resultados apontam que os maiores desafios em progredir academicamente são dificuldades com os conteúdos específicos do primeiro semestre do curso; dificuldade em compreender as metodologias adotadas por professores no Ensino Superior; formação de conceitos elementares de matemática durante a Educação Básica, como também dificuldades socioeconômicas: deslocamento para instituição, conciliar trabalho e estudo, falta de tempo para dedicar aos estudos, falta de motivação e problemas familiares. No tocante aos motivos que podem dificultar a permanência dos ingressantes na instituição estão: dificuldade no processo de ensino/aprendizagem, limitações financeiras, não se identificar com o curso e a expectativa de ingresso em outro curso. Conclusão: Assim, evidencia-se que os fatores apresentados pelos ingressantes colaboram para as suas dificuldades no curso e que medidas precisam ser tomadas para que os estudantes possam desenvolver-se sem muitos obstáculos, tendo êxito em seu percurso formativo, além de uma formação docente de qualidade.
Surgomics and the Artificial intelligence, Radiomics, Genomics, Oncopathomics and Surgomics (AiRGOS) Project
Authors: Gumbs Andrew A. , Croner Roland , Abu-Hilal Mohammed , Bannone Elisa , Ishizawa Takeaki , Spolverato Gaya , Frigerio Isabella , Siriwardena Ajith , Messaoudi Nouredin
Published: September 2023

The journal Artificial Intelligence Surgery was established to explore the integration of Artificial Intelligence (AI) in surgery. It originated from the desire to understand the potential of true robotic surgery, as existing robotic systems are tele-manipulators rather than autonomous robots. AI’s role in surgery involves levels of autonomy and a balance between human expertise and technological advancements. In this regard, a new field of Surgiomics emerges, integrating patient data such as genomics, radiomics, and pathomics to enhance surgical decision-making. Overcoming limitations in surgical data analysis, AI processes vast amounts of data, detects subtle patterns, and explores complex relationships. As Surgiomics continues to evolve, it holds the potential to reshape surgical patient management. Initiatives like the Artificial intelligence, Radiomics, Genomics, Oncopathomics and Surgomics (AiRGOS) Project aim to develop AI algorithms for precision therapeutic treatments in cancer patients using radiologic imaging, genomic sequencing, and clinical data. In this commentary, we envision a future where AI technologies revolutionize surgical decision-making and create personalized treatment plans based on comprehensive patient data.
Reduction of the Benzo[a]pyrene-Induced Hepatotoxicity by Neferine in Lotus and Daidzein, Genistein in Soybean
Authors: Kim Yong Yeon , Shin Han Seung
Published: September 2023

The objective of the this study was to reduce the benzo[a]pyrene-induced hepatotoxicity method in herbal medicine products and to give proof that neferine, daidzein, genistein possess antihepa-totoxic effects. B[a]P which classified as a group 1 carcinogen and metabolized to B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE) causes mutagenic DNA addition products. The reduc-tion of BPDE-DNA adduct formation by B[a]P-7,8-dihydrodiol-9,10-epoxide (BPDE) was derived by benzo[a]pyrene (B[a]P). In HepG2 cells, B[a]P exhibited toxicity and substance treatment of the cells with B[a]P with neferine in lotus and daidzein, genistein in soybean reduced the BPDE-DNA ad-ducts level. The level of B[a]P-metabolites in the substance treatment of the cells was presented that BPDE levels were reduced by neferine in lotus and daidzein, genisten in soybean. These results suggest that neferine in lotus and daidzein, genistein in soybean prevent B[a]P-induced hepato-toxicity for BPDE-DNA adduct formation.
C-Type Lectin-like Receptor 2 Expression Is Decreased upon Platelet Activation and Is Lower in Most Tumor Entities Compared to Healthy Controls
Authors: Etemad Mani , Christodoulou Foteini , Uhlig Stefanie , Hassel Jessica C. , Schrotz-King Petra , Brenner Hermann , Ulrich Cornelia M. , Bieback Karen , Klüter Harald , Bugert Peter
Published: September 2023

The C-type lectin-like receptor 2 (CLEC-2) is expressed on platelets and mediates binding to podoplanin (PDPN) on various cell types. The binding to circulating tumor cells (CTCs) leads to platelet activation and promote metastatic spread. The increased level of soluble CLEC-2 (sCLEC-2), presumably, released from activated platelets was shown in patients with thromboinflammatory and malignant disease. However, the functional role of sCLEC-2 and the mechanism of sCLEC-2 release is not known. In this study, we focused on the effect of platelet activation on CLEC-2 expression and the sCLEC-2 plasma level in cancer patients. First, citrated blood from healthy volunteer donors (n=20) was used to measure the effect of platelet stimulation by classical agonists and PDPN on aggregation, CLEC-2 expression on platelets by flow cytometry, sCLEC-2 release to the plasma by ELISA and total CLEC-2 expression by Western blot analysis. Second, sCLEC-2 was determined in plasma samples from healthy donors (285) and patients with colorectal carcinoma (CRC; 194), melanoma (160), breast cancer (BC; 99) or glioblastoma (49). PDPN caused a significant increase of the aggregation response induced by classical agonists. ADP or PDPN stimulation of platelets caused a significant decrease of CLEC-2 on platelets and sCLEC-2 in the plasma, whereas, total CLEC-2 in platelet lysates remained the same. Thus, the increased plasma level of sCLEC-2 is not a suitable biomarker of platelet activation. In patients with CRC (median 0.9 ng/mL), melanoma (0.9 ng/mL) or BC (0.7 ng/mL) we found significantly lower sCLEC-2 levels (p<0.0001), whereas, glioblastoma patients displayed higher levels (2.6 ng/mL; p=0.0233) compared to healthy controls (2.1 ng/mL). The low sCLEC-2 plasma level observed in most of the tumor entities of our study, presumably, results from the internalization of sCLEC-2 by activated platelets or binding of sCLEC-2 to CTC.
Seaweed Superfoods: Bioactive Nutraceuticals for Coeliac Disease, Diabetes and Hyperglycemia Support
Authors: Tavares Joana O. , Cotas João , Valado Ana , Pereira Leonel
Published: September 2023

The number of people with gluten-related illnesses has been increasing and the available treatments include the introduction of a gluten-free diet. In the bakery industry, there are problems with gluten-free products, namely the important characteristics that this component gives to doughs and the low nutritional value they present. A disease that has also increased in recent years is diabetes mellitus, which is characterized by a lack of insulin and the effectiveness of its action (type 1 diabetes) or tissue insensitivity to the hormone (type 2 diabetes). In terms of treatments, there are several approaches: inhibition of digestive enzymes (α-amylase and α-glucosidase) or techniques based on mechanisms of action (stimulation of insulin production and release, insulin transport and decreased glucose absorption). Hyperglycemia is also associated with the production of reactive oxygen species, which leads to cell apoptosis. On the other hand, there was also an association with high levels of cholesterol in the body, which contributed to the development of other types of diseases. In this sense, macroalgae have been studied as a source of natural compounds and used as food supplements, due to their protein, amino acid and mineral content, and the anti-diabetic effect in controlling the glycemic index, oxidative stress and cholesterol have already been demonstrated. Seaweed emerges as a promising source of bioactive nutraceuticals for individuals with coeliac disease, diabetes, and hyperglycemia. The rising prevalence of gluten-related illnesses calls for effective treatments, and seaweed's potential in enhancing the nutritional value of gluten-free products is noteworthy. Additionally, its demonstrated anti-diabetic effects, including glycemic index control, oxidative stress reduction, and cholesterol management, make it a valuable dietary supplement. Further research is needed to explore the specific bioactivities of seaweed compounds and their mechanisms of action. Integrating seaweed-based nutraceuticals into diets could complement traditional treatments, offering potential health benefits to those with coeliac disease and diabetes.
Groundwater Level Prediction with Machine Learning to Support Sustainable Irrigation in Water Scarcity Regions
Authors: Li Wanru , Finsa Mekuanent Muluneh , Laskey Kathryn Blackmond , Houser Paul , Douglas-Bate Rupert
Published: September 2023

In water scarcity regions, using data-driven approaches to predict groundwater level is challenging due to limited data availability. However, these regions have substantial water needs and require cost-effective groundwater utilization strategies. In this study, we use artificial intelligence to predict groundwater levels to provide guidance for drilling shallow boreholes for subsistence irrigation. The Bilate watershed, which is located in southern Ethiopia, was selected as the study area. This is typical of areas in Africa with high demand for water and limited availability of well data. Using a non-time-series database of 75 boreholes, machine learning models including multiple linear regression, multivariate adaptive regression spline, artificial neural networks, random forest regression, and gradient boosting regression (GBR) were constructed to predict the depth to the water table. 20 independent variables were considered in the models. GBR performed the best of the approaches with an average 0.77 R-squared value on testing data. Finally, a map of predicted water levels in the Bilate watershed was created based on the best model with water levels ranging from 1.6 to 245.9 meters. With the limited set of borehole data, the results show a clear signal that can provide guidance for borehole drilling decisions for sustainable irrigation with additional implications for drinking water.
Functional Load Capacity of Teeth with Reduced Periodontal Support: A Finite Element Analysis
Authors: Dederichs Marco , Joedecke Paul , Weber Christian-Toralf , Guentsch Arndt
Published: September 2023

The purpose of this study was to investigate the functional load capacity of the periodontal ligament (PDL) in a full arch maxilla and mandible model using numerical simulation. The goal of was to determine the functional load pattern in multi- and single rooted teeth with full and reduced periodontal support. CBCT data were used to create 3D-models of a maxilla and mandible. The DICOM dataset was used to create a CAD-model. For a precise description of the surfaces of each structure (enamel, dentin, cementum, pulp, PDL, gingiva, bone), each tooth was segmented separately, and the biomechanical characteristics were considered. A Finite-Element-Analysis (FEA) software computed the biomechanical behavior of stepwise increased force of 700N in cranial and 350N in ventral direction of the muscle approach of the Masseter muscle. The periodontal attachment (cementum-PDL-bone contact) was subsequently reduced in 1mm increments and the simulation repeated. Quantitative (pressure, tension, and deformation) and qualitative (color-coded images) data were recorded and descriptively analyzed. The teeth with the highest load capacities were the upper and lower molars (0.4-0.6MPa), followed by the premolars (0.4-0.5MPa) and canines (0.3-0.4MPa) when vertically loaded. Qualitative data showed that the area with the highest stress in the PDL were for single rooted teeth the cervical and apical area and for molars additionally the furcation roof. In both, single- and multi rooted teeth the gradual reduction of the bone levels caused an increase of the load on the remaining PDL. Cervical and apical areas as well as the furcation roof are the zones with the highest functional stress. The more bone loss, the higher the mechanical load on the residual periodontal supporting structures.
Abnormal Articulation Detecting Model with Fluctuation Measurements Using Acoustic Analysis
Authors: Yagi Naomi , Hata Yutaka , Sakai Yoshitada
Published: September 2023

Articulation disorder is a condition in which the mouth, tongue, vocal cords, and other parts of the body that play an important role in producing voice are damaged, resulting in the inability to produce sound. To diagnose articulation disorders, the movement and shape of each organ concerned with pronunciation are examined. If necessary, the underlying disease or disorder should be managed properly. In it, a speech therapist tests your pronunciation. The observation of conversation and the examination of the pronunciation of each syllable are used to distinguish between mistakes and the degree of articulation disorder. However, these processes are time consuming and labor intensive and are subjective judgments by experts. Therefore, it is important to investigate the characteristics of vocal signals by acoustic analysis of speech objectively. In this study, we focused on fluctuations in the period and amplitude of speech signals and predicted a model for detecting abnormal articulations using fluctuation measurement of the voice data in six healthy subjects and nine patients with an articulation disorder. We used inverse probability of treatment weighting to match the variability for the two groups using the inverse of propensity scores. As the results, the classification performance area under the curve was 0.781 (sensitivity: 0.781, specificity: 0.680) for healthy subjects and patients. We conclude that acoustic analyzing techniques are useful for diagnosing and treating articulation disorders.
Improved Genetic Algorithm for Train Platform Rescheduling Under Train Arrival Delays
Authors: Ding Shuxin , Zhang Tao , Wang Rongsheng , Sun Yanhao , Zhou Xiaozhao , Chen Chen , Yuan Zhiming
Published: September 2023

In this study, the train platform rescheduling problem (TPRP) at a high-speed railway station is analyzed. The adjustments of the train track assignment and train arrival/departure times under train arrival delays are addressed in the TPRP. The problem is formulated as a mixed-integer nonlinear programming model that minimizes the weighted sum of total train delays and rescheduling costs. An improved genetic algorithm (GA) is proposed, and the individual is represented as a platform track assignment and train departure priority, which is a mixed encoding scheme with integers and permutations. The individual is decoded into a feasible schedule comprising the platform track assignment and arrival/departure times of trains using a rule-based method for conflict resolution in the platform tracks and arrival/departure routes. The proposed GA is compared with state-of-the-art evolutionary algorithms. The experimental results confirm the superiority of the GA, which uses the mixed encoding and rule-based decoding, in terms of constraint handling and solution quality.
A hallható levegővétel és a néma szünetek összefüggése gyermekek spontán beszédében
Authors: Gyarmathy Dorottya , Horváth Viktória
Published: September 2023

A néma szünetnek a beszédben számos funkciója ismert, kevésbé kutatott terület azonban a szünet és a hallható lélegzetvétel összefüggése. Felnőtteknél igazolták, hogy a beszédlégzés a magasabb tervezési folyamatoknak van alárendelve. A tanulmány célja a szünettartási stratégiák és a légzés összefüggésének a vizsgálata gyermekek spontán beszédében. Feltételezéseink szerint a gyermekek a kisebb tüdőkapacitás és a kevesebb beszédtapasztalat miatt kevésbé képesek összehangolni a légzést és a szünettartás különböző funkcióit. Ennek bizonyítására 40 narratívát elemeztünk 6–9 éves gyermekektől. Vizsgáltuk a néma szünetek gyakoriságát, funkcióit, temporális jellemzőit különös tekintettel a hallható levegővételre. Az akusztikai elemzéseket a Praat szoftverrel, a statisztikai vizsgálatokat az SPSS szoftverrel végeztük. Az eredmények szerint a gyermekek a felnőttekhez képest kevésbé képesek szabályozni a levegővétel és a néma szünetek viszonyát, de a szünettartásban már óvodáskorban is kimutathatók bizonyos felnőttkorra jellemző mintázatok.
Nyelvfejlesztés a mindennapokban, nem mindennapi módon. Beszámoló a Nyelv- és beszédfejlesztés a közoktatásban című workshopról
Authors: Julianna Jankovics , Pintér Nóra
Published: September 2023

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Balázs Géza – Lengyel Klára (szerk.): Grammatika és oktatás – időszerű kérdések. Struktúra, funkció, szemiotika, hálózat. Tanulmánykötet (Varga-Sebestyén Eszter)
Authors: Varga-Sebestyén Eszter
Published: September 2023

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A Gyermeknevelés folyóirat
Authors: Pachné Heltai Borbála
Published: September 2023

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A Language Teaching Research folyóirat
Authors: Csapó Gerda
Published: September 2023

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Szövegértés alapú narratívaalkotás középiskolás korban
Authors: Laczkó Mária
Published: September 2023

A szövegértés-alapú narratívaalkotás összetett folyamata során a hallott tartalom visszaadása történik saját szavainkkal. Ez olyan félreproduktív beszédhelyzet, amelyben a létrehozott narratíva a spontán beszéd vizsgálatával egyidejűleg a szövegértés elemzését is lehetővé teszi. Ez a feladattípus a közoktatásban az alsó tagozaton is szokásos iskolai gyakorlat. Vizsgálata később, így a középiskolában is fontos lehet, hiszen a produkciós jellemzőkből lehet a percepciós sajátosságokra következtetni, valamint számtalan iskolai feladat, így például a jegyzetelés alapját képezheti, előfordul az idegen nyelvű érettségi vizsga részfeladataként és egyes nyelvvizsgák részeként is. Jelen munka 11. osztályos technikumi és szakközépiskolai tanulók szövegértés-alapú narratívaalkotási folyamatát elemzi a létrehozott produktumok hossza, szógazdagsága alapján. Az elemzés kiterjed továbbá a helyesen felidézett tartalmi elemek mennyiségére, minőségére és a tartalmi elemek felidézésekor megjelenő hibák tipizálására. A tanulmány eredményei rámutatnak a feladattípus középiskolai gyakoroltatásának a szükségességére.
Beszámoló a Variológiai Kutatócsoport (VaKu) nemzetközi tudományos szimpóziumáról
Authors: Ribná Barbara
Published: September 2023

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Évfordulók bűvöletében: Az Eperjesi Egyetem Magyar Nyelv és Kultúra Intézetéről
Authors: Radics Rudolf
Published: September 2023

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Rehabilitation technologies in orthopedic dentistry using ceramic implants.
Authors:   N. A. Semashko National Research Institute of Public Health, Ulyanov Yu.A. , Mingazova E. N. ,   N. A. Semashko National Research Institute of Public Health,   Kazan State Medical University
Published: September 2023

Studies have shown that up to 6% of the population have an allergic reaction to titanium, which can lead to implant loss (non-integration or rejection) and peri-implantitis. At the same time, for more than 25 years, zirconium dioxide (ZrO2) has been successfully used as a material for the manufacture of suprastructures and retainers of dental implants in metal-free restorations, which demonstrates excellent biomechanical properties, such as high fracture toughness and flexural strength, and also ensures successful osseointegration. The European Society for Ceramic Implantology (ESCI) global survey on the performance of ceramic implants confirmed the benefits of zirconia in terms of biocompatibility and a weak association with inflammation. The review of the literature made it possible to identify a number of advantages of modern technologies in orthopedic dentistry using ceramic implants, which make it possible to improve the quality of providing orthopedic dental care to the population in terms of safety and reliability.
Plan de negocio para la producción y ventas de crisinos hechos en base a moringa
Authors:   , Flores Loyola Alexandra Sayuri , Luna Palomino Keyla Jasmin , Marroquin Alarcon Nancy Aracelli , Zanabria Pomatay Rosario Alejandra
Published: September 2023

Actualmente en nuestro país se vienen dando casos alarmantes de enfermedades crónicas como la anemia, diabetes y sobrepeso en un considerable porcentaje de la población, es por ello que nuestra idea de negocio “Mallkikawsay” tiene como objetivo contribuir a la prevención y ayudar a combatir los principales problemas que aquejan al público objetivo, mediante la propuesta del producto desarrollado crisinos a base de moringa. Dicha propuesta contiene una diversidad de beneficios saludables y naturales que ayudarán a contrarrestar dichos problemas, además de su valor agregado en el empaque aislante de bacterias y virus que no permiten el paso de dichos agentes al contenido del producto, protegiendo así la salud de los consumidores en la situación actual en la que vivimos. Como consecuencia, se realizó un análisis de mercado en la que se vio la aceptación del público, posteriormente a ello se aplicó un estudio tanto cualitativo como cuantitativo, donde se obtuvo la aceptación de nuestro producto, entre otras ideas de mejora como por ejemplo del empaque, la cantidad del producto, así como los canales de venta que serían de la preferencia de los clientes. Finalmente se concluye que nuestra idea de negocio es viable gracias a la realización de los estudios financieros y económicos; en ese sentido lo que buscamos es concientizar al consumo de productos saludables, así como el tener una alimentación balanceada.
Assessing the accuracy of the Revised Cardiac Risk Index compared to the American Society of Anaesthesiologists physical status classification in predicting Pulmonary and Cardiac complications among non-cardiothoracic surgery patients at Muhimbili National Hospital
Authors: Khamisi Ramadhan H. , Chrisant Elias Makoye , Muhamba Frank , Mwanga Ally Hamis , Mbuyamba Hervé Tshikomba
Published: September 2023

Background The Revised Cardiac Risk Index (RCRI) and the American Society of Anaesthesiologists (ASA-PS) classification system are two commonly used tools for preoperative risk assessment. This study aimed to assess the accuracy of RCRI compared to the ASA-PS classification system in preoperative risk assessment for pulmonary and cardiac problems among non-cardiothoracic surgery patients admitted at Muhimbili National Hospital (MNH).Methods This was a prospective cross-sectional study design conducted from August 2022 to April 2023 among 184 patients of 18 years and above admitted at MNH for elective non-cardiothoracic surgery. Data Analysis was conducted using STATA software version 16. Means and standard deviations were used to summarize continuous data. Frequencies and percentages were used to summarize categorical data. The logistic regression and ROC curve analysis were used to determine the correlation between variables.Results The majority of patients (43.3%) had an RCRI score of 1 point, and 39.9% were classified as ASA class 1. Patients in ASA classes 3 and 4 had higher odds of developing cardiac and pulmonary complications (AUC = 0.75 and 0.77, respectively). Patients with an RCRI score of 2 or ≥ 3 points were also more likely to experience cardiac and pulmonary complications (AUC = 0.73 and 0.72, respectively). There was no significant difference in the predictive ability of the two tools. Both RCRI and ASA-PS classification systems were equally effective in predicting these complications.Conclusion Both the RCRI and the ASA-PS classification system demonstrated good predictive ability for cardiac and pulmonary complications among patients undergoing non-cardiothoracic surgery.
Improved Therapeutic Efficacy of Doxorubicin Chemotherapy with Cannabidiol in 4T1 Mice Breast Cancer Model
Authors: Tabatabaei Koorosh , Moazzezi Sara , Emamgholizadeh Mohammadreza , Vaez Haleh , Baradaran Behzad , Shokouhi Behrooz
Published: September 2023

Background
Breast cancer is one of the world’s most frequently diagnosed malignancy and the second highest cause of all cancers in females. This cancer mortality is mostly due to lung metastasis. High dose chemotherapy is one of therapeutic strategies beside others. Doxorubicin (DOX) is a widely used chemotherapy agent. however, use of DOX is limited due to its dose- depended cardiotoxic effects. Recently, cannabidiol (CBD) shows anti-tumoral and cardioprotective effects so we aimed to CBD administration with high-dose DOX chemotherapy can improve anticancer effect and reduce cardiotoxicity side effect.
Method
Mice breast cancer model established by injecting 4T1 cell lines. One group did not injected by 4T1 cells as a not cancerous group and administrated normal saline (1ml). In cancerous groups one group consider as cancerous control and administrated normal saline (1ml), other one administrated only DOX (5 mg/kg, IV) on day 1,7,14, other administrated CBD (5 mg/kg, IP) as DOX schedule, nex group administrated CBD and DOX at same time with previews doses and schedule, the last one administrated CBD one day before DOX as pretreatment. On day 21 all mice sacrificed, heart and lungs obtained and histological section preformed. SOD2, iNOS, MMP2, MMP9 evaluated through western blot and TUNEL test preformed for breast tumor.
Results
TUNEL test demonstrated CBD + DOX and pretreatment group was significantly green even compare to DOX group (P < 0.05). In CBD + DOX SOD2 increased and iNOS, MM2 and MMP9 decreased.
Conclusions
This study shows CBD + DOX at same time can increase anti-tumoral effect and reduce DOX cardiotoxicity effect. However CBD alone had a cardioroxic effect.
Optimization process and influence of processing conditions on physical, thermal and textural characteristics of Nigerian pasta produced from acha flour and defatted moringa powder
Authors: OlayemiRaji Akeem , Olaitan Isiaka Mubarak , Omeiza Maxwell Yemmy Mitchel , Sanusi Mayowa Saheed
Published: September 2023

The consumption of Nigerian lesser known crops has been advocated by many researchers. Replacement of wheat flour with acha and de-fatted moringa cake in pasta production was investigated to reduce dependence on wheat flour. Optimization process of pasta production from acha flour (AF) and defatted moringa powder (DMP) carried out using standard method, with the objectives of determining optimum processing condition by applying hybrid of Taguchi Orthogonal Array Design and Response Surface Methodology of Design Expert version 6.0. The independent variables were barrel temperature (110–150 ºC), barrel speed (240–360 rpm) and moisture content (30–40%). The responses ranged as follows: hardness (18.96–27.83 N), springiness (0.41–0.71), adhesiveness (0.09–0.59 N/m2), cohesiveness (0.35–0.64), chewiness (3.85–11.89 N/m2), gumminess (9.23–17.63 N/m2), energy peak (0.01–0.02 kg/m2), color characteristics (L* (0.07–2.20), a* (0.32–1.07) and b* (0.21–2.11)), cooking time (4.00–6.00 min), cooking loss (5.66–8.05 g/100g), water uptake (10.08–98.65%), elongation ratio (0.82–1.08), specific heat capacity (Cp) (177.31–196.45 kJ/kg/K), thermal conductivity (27.31–29.64 W/m/K) and thermal diffusivity (8.17–8.81 x 10− 6 m2/s). The variation in processing conditions significantly (p < 0.05) influenced all the responses. However, the principal component analysis (PCA) of the physical, thermal and instrumental textural characteristics of pastas showed positive correlations except for adhesiveness and overall acceptability. Conclusively, dough moisture content of 39.85%, barrel speed of 240 rpm and barrel temperature of 110°C gave the optimal extrusion process condition for the production of high-quality pasta.
Cavity-mediated long-range interactions in levitated optomechanics
Authors: Novotny Lukas , Vijayan Jayadev , Piotrowski Johannes , Gonzalez-Ballestero Carlos , Weber Kevin , Romero-Isart Oriol
Published: September 2023

The ability to engineer cavity-mediated interactions has emerged as a powerful tool for the generation of non-local correlations and the investigation of non-equilibrium phenomena in many-body systems. Levitated optomechanical systems have recently entered the multi-particle regime, with promise for using arrays of massive strongly coupled oscillators for exploring complex interacting systems and sensing. Here, by combining advances in multi-particle optical levitation and cavity-based quantum control, we demonstrate, for the first time, programmable cavity-mediated interactions between nanoparticles in vacuum. The interaction is mediated by photons scattered by spatially separated particles in a cavity, resulting in strong coupling (Gzz/Ωz = 0.238 ± 0.005) that does not decay with distance within the cavity mode volume. We investigate the scaling of the interaction strength with cavity detuning and inter-particle separation, and demonstrate the tunability of interactions between different mechanical modes. Our work paves the way towards exploring many-body effects in nanoparticle arrays with programmable cavity-mediated interactions, generating entanglement of motion, and using interacting particle arrays for optomechanical sensing
Belief in omens and superstitions among patients with chronic neurological disorders
Authors: Mameniškienė Rūta , Kizlaitienė Rasa , Lokominienė Rūta Kaladytė , Puteikis Kristijonas
Published: September 2023

Chronic neurological disorders may affect various cognitive processes, including religiosity or superstitious belief. We tested the hypotheses that superstitious beliefs are less prevalent in Parkinson’s disease (PD) and more prevalent in people with epilepsy (PWE) than in patients with multiple sclerosis (MS) or healthy controls (HCs). We conducted an anonymous survey among outpatients and HCs by asking them to ascribe meaning or report belief for 27 culturally adapted statements (9 omens and 18 superstitions). The sum of items that a respondent believes in was labelled the superstition index (SI). The SI was compared between groups by means of the Kruskal-Wallis (H) test and negative binomial regression modelling. Two-step cluster analysis was performed to discern different subgroups based on answers to the items of the SI. There were 553 respondents who completed the questionnaire (183 PWE, 124 patients with PD, 133 with MS and 113 HCs). Complete SI scores were collected for 479 (86.6%) participants and they were lower in patients with PD (n = 96, Md = 1, IQR = 0-5.75) in comparison to those with epilepsy (n = 155, Md = 6, IQR = 1–14), MS (n = 120, Md = 4, IQR = 0–12) or HCs (n = 108, Md = 4.5, IQR = 1–10), H(3) = 26.780, p < 0.001. The negative binomial regression model (n = 394, likelihood ratio χ2 = 35.178, p < 0.001), was adjusted for sex, place of residence, income and education, and female sex was the only characteristic associated with the SI (β = 0.423, OR = 1.526, 95% CI = 1.148 to 2.028). Both female sex (β = 0.422, OR = 1.525, 95% CI = 1.148 to 2.026) and Parkinson’s disease (β=-0.428, OR = 0.652, 95% CI = 0.432 to 0.984) were significant predictors of the SI when age was removed from the model. Two-step cluster analysis resulted in individuals with PD being grouped into “extreme non-believer”, “non-believer” and “believer” rather than “non-believer” and “believer” clusters characteristic for PWE, patients with MS and HCs. Our study suggests that individuals with PD believe in less superstitions than patients with MS, PWE or HCs. The results of this investigation should be independently confirmed after adjusting for PD-specific variables.
Genome-wide CRISPR screening identifies a role for ARRDC3 in TRP53-mediated responses
Authors: Herold Marco , Marca John La , Aubrey Brandon , Yang Bruce , Chang Catherine , Wang Zilu , Kueh Andrew , Tai Lin , Wilcox Stephen , Milla Liz , Heinzel Susanne , Vremec David , Whelan Lauren , koenig christina , Kaloni Deeksha , Voss Anne , Strasser Andreas , Diepstraten Sarah , Kelly Gemma
Published: September 2023

Whole-genome screens using CRISPR technologies are powerful tools to identify novel tumour suppressors as well as factors that impact responses of malignant cells to anti-cancer agents. Applying this methodology to lymphoma cells, we conducted a genome-wide screen to identify novel inhibitors of tumour expansion that are induced by the tumour suppressor TRP53. We discovered that the absence of Arrestin domain containing 3 (ARRDC3) increases the survival and long-term competitiveness of MYC-driven lymphoma cells when treated with anti-cancer agents that activate TRP53. Deleting Arrdc3 in mice caused perinatal lethality due to various developmental abnormalities, including cardiac defects. Notably, the absence of ARRDC3 markedly accelerated MYC-driven lymphoma development. Thus, ARRDC3 is a new mediator of TRP53-mediated suppression of tumour expansion, and this discovery may open new avenues to harness this process for cancer therapy.
Can network infrastructure development help farmers cross the "digital divide"?
Authors: Meng Xiangtai , Sun Shiying , Ding Xin
Published: September 2023

Addressing the digital divide that plagues rural areas has become an important issue in narrowing the urban-rural gap and achieving common prosperity. This article examines the impact of network infrastructure on rural households' ability to cross the digital divide by using the "broadband rural" strategy as a proxy variable for network infrastructure and combining data from the China Family Panel Studies (CFPS) with a score propensity matched difference-in-differences model (PSM-DID). The results show that network infrastructure can help farmers cross the access and use divide, but does not contribute significantly to crossing the ability divide in the current period. A triple difference model (DDD) was introduced to test the effect of network technology training on the contribution of network infrastructure to the ability gap, and the ability gap needs to be based on the use gap, so there is a delay in the response of the ability gap to policy. Further analysis reveals that network infrastructure mainly facilitates non-farm occupational groups to cross the capability divide, and facilitates middle-aged and young people to cross the digital divide, and does not have significant effects on groups involved in agricultural work and older people. In view of this, the network infrastructure should be continuously promoted, public service training on digital skills should be organized, electronic products and information services should be created exclusively for the elderly group and the group involved in agricultural production, and the ability of farmers to apply the network to their production life should be strengthened.
Conjugated linoleic acid reduces lipid accumulationvia down-regulation expression of lipogenic genes and up-regulation of apoptotic genes in grass carp（Ctenopharyngodon idella）adipocyte in vitro
Authors: Yu Hua , Zou Zhao-xia , Wei Wei , Li Ying
Published: September 2023

The relationship between conjugated linoleic acid (CLA) and lipogenesis has been extensively studied in mammals and some cell lines, but it is relatively rare in fish, and the potential mechanism of action of CLA reducing fat mass remains unclear. The established primary culture model for studying lipogenesis in grass carp (Ctenopharyngodon idella) preadipocytes was used in the present study, and the objective was to explore the effects of CLA on intracellular lipid and TG content, fatty acid composition, and mRNA levels of adipogenesis transcription factors, lipase and apoptosis genes in grass carp adipocytes in vitro. The results showed that CLA reduced the size of adipocyte and lipid droplet, decreased the content of intracellular lipid and TG, which was accompanied by a significant downregulation of mRNA abundance in the transcriptional regulators (PPARγ, C/EBPα, SREBP-1c ), lipase genes(LPL、 FAS、ACC) and decreasing the content of SFAs, n-6 PUFA, increasing the content of MUFA and n-3 PUFA in primary grass carp adipocyte. In addition, CLA induced adipocyte apoptosis through downregulated anti-apoptotic gene(Bcl-2 ) mRNA level, upregulated pro-apoptotic genes(TNF-α, Bax, Caspase-3, and Caspase-9) mRNA level in a dose-dependent manner. These findings suggest that CLA can act on grass carp adipocytes through various pathways, including decreasing adipocyte size, altering fatty acid composition, restraining adipocyte differentiation, promoting adipocyte apoptosis, and thereby reducing lipid accumulation.
Is embodied renewable energy transfer greening the global supply chain?
Authors: Yang Yu , Chen Yan , Poon Jessie , Qian Xiaoyin , Zhou Yannan , Xia Siyou
Published: September 2023

Energy underpins international trade, and a greener energy mix can contribute to cleaner global supply chains (GSCs). This paper examines how energy transition has influenced GSC greening through embodied renewable energy transfer. Specifically, we analyze the contribution of countries/regions and sectors to the greening process from 2011 to 2021. We find some evidence of GSC greening over the period as the ratio of renewable energy in total transferred energy increased from 4.2% to 7.6%. Emerging economies that have advanced rapidly in energy transition are gradually overtaking developed countries in their contribution to GSC greening. Sectors with a higher electrification rate are main contributors to GSC greening led by significant inter-sectoral spillovers from the heavy industry and business services. However, transfer of embodied renewable energy by high-income developed countries is concentrated in other high-income countries raising concerns of limited access by low-income developing countries and the amelioration of global energy welfare inequality.
Determinants of Tax Evasion: Evidence from Hawassa City Taxpayers
Authors: Negash Tekalign
Published: September 2023

The authors have requested that this preprint be removed from Research Square.