bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolutionary Advantages of Stimulus-Driven EEG Phase Transitions in the Upper Cortical Layers
Authors: Kozma Robert , Baars Bernard J. , Geld Natalie
Published: December 2021

Spatio-temporal brain activity monitored by EEG recordings in humans and other mammals has identified beta/gamma oscillations (20–80 Hz), which are self-organized into spatio-temporal structures recurring at theta/alpha rates (4–12 Hz). These structures have statistically significant correlations with sensory stimuli and reinforcement contingencies perceived by the subject. The repeated collapse of self-organized structures at theta/alpha rates generates laterally propagating phase gradients (phase cones), ignited at some specific location of the cortical sheet. Phase cones have been interpreted as neural signatures of transient perceptual experiences according to the cinematic theory of brain dynamics. The rapid expansion of essentially isotropic phase cones is consistent with the propagation of perceptual broadcasts postulated by Global Workspace Theory (GWT). What is the evolutionary advantage of brains operating with repeatedly collapsing dynamics? This question is answered using thermodynamic concepts. According to neuropercolation theory, waking brains are described as non-equilibrium thermodynamic systems operating at the edge of criticality, undergoing repeated phase transitions. This work analyzes the role of long-range axonal connections and metabolic processes in the regulation of critical brain dynamics. Historically, the near 10 Hz domain has been associated with conscious sensory integration, cortical “ignitions” linked to conscious visual perception, and conscious experiences. We can therefore combine a very large body of experimental evidence and theory, including graph theory, neuropercolation, and GWT. This cortical operating style may optimize a tradeoff between rapid adaptation to novelty vs. stable and widespread self-organization, therefore resulting in significant Darwinian benefits.
Herbal NF-κB Inhibitors Sensitize Rituximab-Resistant B Lymphoma Cells to Complement-Mediated Cytolysis
Authors: Ge Xiaowen , Du Yiqun , Chen Jianfeng , Zhu Na , Yao Jiamei , Zhang Xin , Wang Na , Sun Yujing , Gao Feng , Hu Weiguo , Hou Yingyong
Published: December 2021

Background

Drug resistance remains a serious challenge to rituximab therapy in B-NHL (B cell non-Hodgkin’s lymphoma). CDC (complement-dependent cytotoxicity) has been proposed as a major antitumor mechanism of rituximab, and direct abrogation of CD59 function partially restores rituximab sensitivity with high efficacy. However, universal blockade of CD59 may have deleterious effects on normal cells. Sp1 regulates constitutive CD59 expression, whereas NF-κB and CREB regulate inducible CD59 expression.

Methods

Immunohistochemistry (IHC) assay was used to detect the expression levels of CD59 and other related molecules. Quantitative Real-time PCR (RT-PCR) analysis was used to explore the levels of transcripts in the original and resistant cells. We chose LY8 cells to test the effects of NF-κB and CBP/p300 inhibition on CD59 expression using flow cytometry (FACS). Immunoblotting analysis was employed to detect the effects of curcumin and POH. The in vitro and in vivo experiments were used to evaluate the toxicity and combined inhibitory effect on tumor cells of curcumin and POH.

Results

We demonstrated that herbal (curcumin and perillyl alcohol) blockade of NF-κB specifically suppresses the expression of inducible CD59 but not CD20, thus sensitizing resistant cells to rituximab-mediated CDC. Moreover, activation of NF-κB and CREB is highly correlated with CD59 expression in B-NHL tissues.

Conclusions

Our findings suggest the potential of CD59 expression as a predictor of therapeutic efficacy of NF-κB inhibitors in clinical application as well as the rationality of a NF-κB inhibitor-rituximab regimen in B-NHL therapy.
Characterization of Cardiac, Vascular, and Metabolic Changes in Young Childhood Cancer Survivors
Authors: Broberg Olof , Øra Ingrid , Wiebe Thomas , Weismann Constance G. , Liuba Petru
Published: December 2021

Background: Childhood cancer survivors (CCS) are at an increased risk for cardiovascular diseases (CVD). It was the primary aim of this study to determine different measures of cardiac, carotid, lipid, and apolipoprotein status in young adult CCS and in healthy controls.

Methods: Cardiac and common carotid artery (CCA) structure and function were measured by ultrasonography. Lipids and apolipoproteins were measured in the blood. Peripheral arterial endothelial vasomotor function was assessed by measuring digital reactive hyperemia index (PAT-RHI) using the Endo-PAT 2000.

Results: Fifty-three CCS (20–30 years, 35 men) and 53 sex-matched controls were studied. The CCS cohort was divided by the median dose of anthracyclines into a low anthracycline dose (LAD) group (50–197 mg/m2, n = 26) and a high anthracycline dose (HAD) group (200–486 mg/m2, n = 27). Carotid distensibility index (DI) and endothelial function determined by PAT-RHI were both lower in the CCS groups compared with controls (p < 0.05 and p = 0.02). There was no difference in carotid intima media thickness. Atherogenic apolipoprotein-B (Apo-B) and the ratio between Apo-B and Apoliprotein-A1 (Apo-A1) were higher in the HAD group compared with controls (p < 0.01). Apo-B/Apo-A1-ratio was over reference limit in 29.6% of the HAD group, in 15.4% of LAD group, and in 7.5% of controls (p = 0.03). Measured lipid markers (low density lipoprotein and total cholesterol and triglycerides) were higher in both CCS groups compared with controls (p < 0.05). Systolic and diastolic function were measurably decreased in the HAD group, as evidenced by lower EF (p < 0.001) and lower é-wave (p < 0.005) compared with controls. CCA DI correlated with Apo-B/Apo-A1-ratio and Apo-A1. Follow-up time after treatment correlated with decreased left ventricular ejection fraction (p = 0.001).

Conclusion: Young asymptomatic CCS exhibit cardiac, vascular, lipid, and apolipoprotein changes that could account for increased risk for CVD later in life. These findings emphasize the importance of cardiometabolic monitoring even in young CCS.
A Comparability of Renal Length and Volume Measurements in MRI and Ultrasound in Children
Authors: Świętoń Dominik , Bernard Weronika , Grzywińska Małgorzata , Czarniak Piotr , Durawa Agata , Kaszubowski Mariusz , Piskunowicz Maciej , Szurowska Edyta
Published: December 2021

Introduction: Despite the significant increase in use of magnetic resonance imaging (MRI) in children, there is still a lack of normal reference values of renal size in this method and reference values are being interpolated from the ultrasound (US) studies. The study provides comparative analysis of agreement in renal length and volume measurements between MRI and ultrasound.

Materials and Methods: Ninety-three children with a mean age of 8.0 ± 6.0 years, who had undergone both renal US and MRI exams, were included in the study. Participants were divided into three subgroups; each kidney was considered separately.

Group 1 included 106 kidneys without any anomalies. Group 2 comprised 48 kidneys with a dilated collecting system. Group 3 included 32 kidneys with a duplicated collecting system. Measurements were taken in three dimensions, and renal volume was calculated from the ellipsoid formula.

Results: We found no significant difference between US and MRI measurements in Group 1 and Group 2. In Group 3, the difference between measurements in both imaging methods was significant. The mean difference varied from 0.05% in Group 1, 2.95% in Group 2, to 4.99% in Group 3.

Conclusion: The US and MRI are comparable methods in renal size measurements. The interpolation of sonographic renal length and volume reference values to the MRI in the pediatric population is justified, as there is a strong agreement between both methods. Both methods can be used interchangeably for following up of the renal size changes in the pediatric population.
Comprehensive Analysis of Chemical Structures That Have Been Tested as CFTR Activating Substances in a Publicly Available Database CandActCFTR
Authors: Nietert Manuel Manfred , Vinhoven Liza , Auer Florian , Hafkemeyer Sylvia , Stanke Frauke
Published: December 2021

Background: Cystic fibrosis (CF) is a genetic disease caused by mutations in CFTR, which encodes a chloride and bicarbonate transporter expressed in exocrine epithelia throughout the body. Recently, some therapeutics became available that directly target dysfunctional CFTR, yet research for more effective substances is ongoing. The database CandActCFTR aims to provide detailed and comprehensive information on candidate therapeutics for the activation of CFTR-mediated ion conductance aiding systems-biology approaches to identify substances that will synergistically activate CFTR-mediated ion conductance based on published data.

Results: Until 10/2020, we derived data from 108 publications on 3,109 CFTR-relevant substances via the literature database PubMed and further 666 substances via ChEMBL; only 19 substances were shared between these sources. One hundred and forty-five molecules do not have a corresponding entry in PubChem or ChemSpider, which indicates that there currently is no single comprehensive database on chemical substances in the public domain. Apart from basic data on all compounds, we have visualized the chemical space derived from their chemical descriptors via a principal component analysis annotated for CFTR-relevant biological categories. Our online query tools enable the search for most similar compounds and provide the relevant annotations in a structured way. The integration of the KNIME software environment in the back-end facilitates a fast and user-friendly maintenance of the provided data sets and a quick extension with new functionalities, e.g., new analysis routines. CandActBase automatically integrates information from other online sources, such as synonyms from PubChem and provides links to other resources like ChEMBL or the source publications.

Conclusion: CandActCFTR aims to establish a database model of candidate cystic fibrosis therapeutics for the activation of CFTR-mediated ion conductance to merge data from publicly available sources. Using CandActBase, our strategy to represent data from several internet resources in a merged and organized form can also be applied to other use cases. For substances tested as CFTR activating compounds, the search function allows users to check if a specific compound or a closely related substance was already tested in the CF field. The acquired information on tested substances will assist in the identification of the most promising candidates for future therapeutics.
Detection of Microsatellite Instability in Colorectal Cancer Patients With a Plasma-Based Real-Time PCR Analysis
Authors: Kim Namjoo , Kim Sung Min , Lee Beom Jae , Choi Byung il , Yoon Hee Sook , Kang Sang Hee , Kim Seung Han , Joo Moon Kyung , Park Jong-Jae , Kim Chungyeul
Published: December 2021

A microsatellite instability (MSI) test is crucial for screening for HNPCC (Hereditary nonpolyposis colorectal cancer; Lynch syndrome) and optimization of colorectal cancer (CRC) treatment. Mismatch repair (MMR) deficiency is a predictor for good response of immune checkpoint inhibitors in various malignancies. In this study, we evaluated the results of a newly developed plasma-based real-time PCR kit for the detection of MSI in CRC patients. We assessed a peptide nucleotide acid (PNA) probe-mediated real-time PCR test (U-TOP MSI Detection Kit Plus) that determines MSI status by using amplicon melting analysis of five markers (NR21, NR24, NR27, BAT25, and BAT26) from plasma. Eighty-four CRC patients (46 dMMR and 38 pMMR) with colorectal cancer were analyzed. The concordance rate of MSI status assessment between the plasma kit and IHC was 63.0% in dMMR patients (29/46), but in the pMMR evaluation, a 100% (38/38) concordance rate was observed. In the evaluation of the performance of a custom tissue U-TOP MSI Detection Kit and plasma kit in 28 patients, sensitivity, specificity, PPV (positive predictive value) and NPV (negative predictive value) of plasma kit were 68.4, 100, 100, and 44.4%, respectively, with the tissue U-TOP MSI Detection Kit. Our results demonstrate the feasibility of a non-invasive and rapid plasma-based real-time PCR kit (U-TOP MSI Detection Kit Plus) for the detection of MSI in colorectal cancer.
Can Cross-Country Genomic Predictions Be a Reasonable Strategy to Support Germplasm Exchange? – A Case Study With Hydrogen Cyanide in Cassava
Authors: Torres Lívia Gomes , Oliveira Eder Jorge de , Ogbonna Alex C. , Bauchet Guillaume J. , Mueller Lukas A. , Azevedo Camila Ferreira , Fonseca e Silva Fabyano , Simiqueli Guilherme Ferreira , Resende Marcos Deon Vilela de
Published: December 2021

Genomic prediction (GP) offers great opportunities for accelerated genetic gains by optimizing the breeding pipeline. One of the key factors to be considered is how the training populations (TP) are composed in terms of genetic improvement, kinship/origin, and their impacts on GP. Hydrogen cyanide content (HCN) is a determinant trait to guide cassava’s products usage and processing. This work aimed to achieve the following objectives: (i) evaluate the feasibility of using cross-country (CC) GP between germplasm’s of Embrapa Mandioca e Fruticultura (Embrapa, Brazil) and The International Institute of Tropical Agriculture (IITA, Nigeria) for HCN; (ii) provide an assessment of population structure for the joint dataset; (iii) estimate the genetic parameters based on single nucleotide polymorphisms (SNPs) and a haplotype-approach. Datasets of HCN from Embrapa and IITA breeding programs were analyzed, separately and jointly, with 1,230, 590, and 1,820 clones, respectively. After quality control, ∼14K SNPs were used for GP. The genomic estimated breeding values (GEBVs) were predicted based on SNP effects from analyses with TP composed of the following: (i) Embrapa genotypic and phenotypic data, (ii) IITA genotypic and phenotypic data, and (iii) the joint datasets. Comparisons on GEBVs’ estimation were made considering the hypothetical situation of not having the phenotypic characterization for a set of clones for a certain research institute/country and might need to use the markers’ effects that were trained with data from other research institutes/country’s germplasm to estimate their clones’ GEBV. Fixation index (FST) among the genetic groups identified within the joint dataset ranged from 0.002 to 0.091. The joint dataset provided an improved accuracy (0.8–0.85) compared to the prediction accuracy of either germplasm’s sources individually (0.51–0.67). CC GP proved to have potential use under the present study’s scenario, the correlation between GEBVs predicted with TP from Embrapa and IITA was 0.55 for Embrapa’s germplasm, whereas for IITA’s it was 0.1. This seems to be among the first attempts to evaluate the CC GP in plants. As such, a lot of useful new information was provided on the subject, which can guide new research on this very important and emerging field.
Assessment of Canopy Conductance Responses to Vapor Pressure Deficit in Eight Hazelnut Orchards Across Continents
Authors: Pasqualotto Gaia , Carraro Vinicio , Suarez Huerta Eloy , Anfodillo Tommaso
Published: December 2021

A remarkable increase in vapor pressure deficit (VPD) has been recorded in the last decades in relation to global warming. Higher VPD generally leads to stomatal closure and limitations to leaf carbon uptake. Assessing tree conductance responses to VPD is a key step for modeling plant performances and productivity under future environmental conditions, especially when trees are cultivated well outside their native range as for hazelnut (Corylus spp.). Our main aim is to assess the stand-level surface canopy conductance (Gsurf) responses to VPD in hazelnut across different continents to provide a proxy for potential productivity. Tree sap flow (Fd) was measured by Thermal dissipation probes (TDP) probes (six per sites) in eight hazelnut orchards in France, Italy, Georgia, Australia, and Chile during three growing seasons since 2016, together with the main meteorological parameters. We extracted diurnal Fd to estimate the canopy conductance Gsurf.. In all the sites, the maximum Gsurf occurred at low values of VPD (on average 0.57 kPa) showing that hazelnut promptly avoids leaf dehydration and that maximum leaf gas exchange is limited at relatively low VPD (i.e., often less than 1 kPa). The sensitivity of the conductance vs. VPD (i.e., -dG/dlnVPD) resulted much lower (average m = −0.36) compared to other tree species, with little differences among sites. We identified a range of suboptimal VPD conditions for Gsurf maximization (Gsurf > 80% compared to maximum) in each site, named “VPD80,” which multiplied by the mean Gsurf might be used as a proxy for assessing the maximum gas exchange of the orchard with a specific management and site. Potential gas exchange appeared relatively constant in most of the sites except in France (much higher) and in the driest Australian site (much lower). This study assessed the sensitivity of hazelnut to VPD and proposed a simple proxy for predicting the potential gas exchange in different areas. Our results can be used for defining suitability maps based on average VPD conditions, thus facilitating correct identification of the potentially most productive sites.
Functional Characterization of BrF3'H, Which Determines the Typical Flavonoid Profile of Purple Chinese Cabbage
Authors: Park Sangkyu , Lee Hyo , Min Myung Ki , Ha Jihee , Song Jaeeun , Lim Chan Ju , Oh Jinpyo , Lee Saet Buyl , Lee Jong-Yeol , Kim Beom-Gi
Published: December 2021

Flavonols and anthocyanins are the two major classes of flavonoids in Brassica rapa. To elucidate the flavonoid biosynthetic pathway in Chinese cabbage (B. rapa L. subsp. pekinensis), we analyzed flavonoid contents in two varieties of Chinese cabbage with normal green (5546) and purple (8267) leaves. The 8267 variety accumulates significantly higher levels of quercetin, isorhamnetin, and cyanidin than the 5546 variety, indicating that 3′-dihydroxylated flavonoids are more prevalent in the purple than in the green variety. Gene expression analysis showed that the expression patterns of most phenylpropanoid pathway genes did not correspond to the flavonoid accumulation patterns in 5546 and 8267 varieties, except for BrPAL1.2 while most early and late flavonoid biosynthetic genes are highly expressed in 8267 variety. In particular, the flavanone 3′-hydroxylase BrF3′H (Bra009312) is expressed almost exclusively in 8267. We isolated the coding sequences of BrF3′H from the two varieties and found that both sequences encode identical amino acid sequences and are highly conserved with F3'H genes from other species. An in vitro enzymatic assay demonstrated that the recombinant BrF3′H protein catalyzes the 3′-hydroxylation of a wide range of 4′-hydroxylated flavonoid substrates. Kinetic analysis showed that kaempferol is the most preferred substrate and dihydrokaempferol (DHK) is the poorest substrate for recombinant BrF3′H among those tested. Transient expression of BrF3′H in Nicotiana benthamiana followed by infiltration of naringenin and DHK as substrates resulted in eriodictyol and quercetin production in the infiltrated leaves, demonstrating the functionality of BrF3′H in planta. As the first functional characterization of BrF3′H, our study provides insight into the molecular mechanism underlying purple coloration in Chinese cabbage.
A Longitudinal Study on Online Sexual Engagement, Victimization, and Psychosocial Well-Being
Authors: Reer Felix , Wendt Ruth , Quandt Thorsten
Published: December 2021

Several cross-sectional studies have shown that online sexual engagement (OSE) in the form of sexting or sexy self-presentation on social media is associated with an increased risk of experiencing negative consequences, such as online sexual victimization (OSV) or lower levels of psychosocial well-being. However, representative and longitudinal studies are scarce. The current study follows three research goals: (1) examining the prevalence of OSE and OSV among a random-quota sample of 1,019 German Internet users aged 14–64 years, (2) examining gender and age-related differences in OSE and OSV, and (3) examining the longitudinal relationships between OSE, OSV, and psychosocial well-being over a period of 1 year. Our results indicate that OSE and OSV are relatively widespread: 17.7% of the participants had already experienced OSV, 25.3% indicated that they had presented themselves online in a sexualized manner at least once in the past 2 months, and 22.7% showed a certain willingness to engage in sexting. We found higher rates among the younger participants. However, to a certain degree, older individuals were also affected. Male participants showed higher sexting willingness and more often presented themselves in a sexualized manner than females, whereas only small differences related to OSV were found. Concerning relationships with psychosocial well-being, our cross-sectional results showed that OSE, OSV, and mental problems are intercorrelated. Furthermore, we detected a significant long-term relationship between higher sexting willingness at time 1 and more victimization experienced 1 year later, whereas no significant longitudinal associations with lower levels of psychosocial well-being were identified.
Influence of Entrepreneurial Psychology and Spirit on the Cultivation of Students’ Entrepreneurial Values and Ability Under the New Media
Authors: Li Ping , Chen Xiaozhou
Published: December 2021

This paper studies the influence of entrepreneurial spirit on college students’ entrepreneurial ability and entrepreneurial values. Firstly, the impact of entrepreneurial psychology and entrepreneurial spirit on entrepreneurial values is analyzed. Secondly, the role of entrepreneurial values in Innovation and Entrepreneurship Education (IEE) is analyzed and summarized under new media. Then, based on entrepreneurial psychology and entrepreneurial spirit, a Questionnaire Survey (QS) is designed to investigate the entrepreneurial values of students in one university in Shaanxi Province, China. The QS analysis suggests that most respondents hold a positive attitude, and their attitude is on the rise. The QS results of “Reasons for entrepreneurial failure” show that 40.37, 31.9, 25.98, and 11.75% of respondents think they lack financial support, business skills, ability, and understanding of policies and laws, respectively. The QS results of “What factors influence entrepreneurial values?” reveal that 39.43% of the respondents chose the “Models of successful entrepreneurs,” successful entrepreneur models can effectively encourage students to receive IEE, followed by 28.94% who choose “Achieve their own life goals.”. In terms of “Solutions against entrepreneurial risks,” nearly 70% of the students have chosen the negative options. In terms of “Which is the most important entrepreneurial quality?”, more students choose entrepreneurial values rather than entrepreneurial quality, proving that students generally lack entrepreneurial values. Given these problems, corresponding countermeasures are put forward to strengthen entrepreneurial psychology and IEE, in an attempt to cultivate college students’ entrepreneurial values and entrepreneurial ability under the new media. The results provide some data support for the impact of college students’ entrepreneurial values and entrepreneurial ability.
The Effects of Diverse Exercise on Cognition and Mental Health of Children Aged 5–6 Years: A Controlled Trial
Authors: Jia Ningxin , Zhang Xijin , Wang Xu , Dong Xiaosheng , Zhou Yanan , Ding Meng
Published: December 2021

The rate of learning and cognitive development is at its highest level in preschool-aged children, making this stage a critical period. Exercise has received increasing attention for its beneficial physical and mental health effects on the development of preschool children. This study investigated the effects of diverse exercise on the cognition of preschool children. Two classes were randomly selected from kindergarten classes of children aged 5–6 years, and designated as the experimental and control classes. Each class contained 20 children (10 boys and 10 girls) according to the kindergarten class system. The experimental class completed exercises according to the designed curriculum, while control class carried out exercises according to the regular teaching plan, for a study period of 12 weeks. The Wechsler Preschool and Primary Scale of Intelligence (WPPSI) and the Mental Health Questionnaire for Children were used to assess outcomes, both at the beginning and end of study. After 12 weeks, the experimental class has improved in the “Object Assembly,” “Block Design,” “Picture Completion,” and “Coding” (14.70 ± 2.14, p < 0.01; 14.54 ± 1.56, p < 0.01; 9.62 ± 2.06, p < 0.05; 15.92 ± 2.72, p < 0.05) in performance test, and showed improvements in the “Movement,” “Cognitive Ability,” “Sociality” and “Living Habits” (5.65 ± 0.59, p < 0.01; 11.20 ± 1.91, p < 0.05; 9.05 ± 1.72, p < 0.05; 7.10 ± 1.45, p < 0.05) in mental health outcomes. Diverse exercise has a significantly beneficial role in promoting the cognitive development of children aged 5–6 years, as well as a beneficial, albeit insignificant, role in their mental health.
Workplace Ostracism and Counterproductive Work Behaviors: The Chain Mediating Role of Anger and Turnover Intention
Authors: Zhu Yingge , Zhang Denghao
Published: December 2021

This study aims to explore the mediating effect of anger and turnover intention on the relationship between workplace ostracism and counterproductive work behaviors. A two-stage follow-up survey of 426 employees born after 1990 was conducted using the Workplace Ostracism Scale, Counterproductive Work Behaviors Scale, Trait Anger subscale of the State-Trait Anger Expression Inventory, and Turnover Intention Scale. Workplace ostracism was found to be significantly positively correlated with anger, turnover intention, and counterproductive work behaviors. Furthermore, anger and turnover intention both separately and serially mediated the relationship between workplace ostracism and counterproductive work behaviors. This study confirms the chain mediating effect of anger and turnover intention on the relationship between workplace ostracism and counterproductive work behaviors.
A Review of Explicit and Implicit Assumptions When Providing Personalized Feedback Based on Self-Report EMA Data
Authors: Leertouwer IJsbrand , Cramer Angélique O. J. , Vermunt Jeroen K. , Schuurman Noémi K.
Published: December 2021

Ecological Momentary Assessment (EMA) in which participants report on their moment-to-moment experiences in their natural environment, is a hot topic. An emerging field in clinical psychology based on either EMA, or what we term Ecological Retrospective Assessment (ERA) as it requires retrospectivity, is the field of personalized feedback. In this field, EMA/ERA-data-driven summaries are presented to participants with the goal of promoting their insight in their experiences. Underlying this procedure are some fundamental assumptions about (i) the relation between true moment-to-moment experiences and retrospective evaluations of those experiences, (ii) the translation of these experiences and evaluations to different types of data, (iii) the comparison of these different types of data, and (iv) the impact of a summary of moment-to-moment experiences on retrospective evaluations of those experiences. We argue that these assumptions deserve further exploration, in order to create a strong evidence-based foundation for the personalized feedback procedure.
Antecedent Factors of Green Purchasing Behavior: Learning Experiences, Social Cognitive Factors, and Green Marketing
Authors: Susanty Aries , Puspitasari Nia Budi , Prastawa Heru , Listyawardhani Pradhipta , Tjahjono Benny
Published: December 2021

This study extends the theory of planned behavior (TPB) framework by introducing three further variables (i.e., learning experience, contextual factors, and green marketing) to explain how behavioral intention and actual behavior are induced by situational factors as well as green advertising from the company. Then, this study has four objectives. First, this study will assess the direct effect of personal factors (i.e., demographic factors) and contextual factors on learning experience and the direct effect of personal factors (i.e., demographic factors) on subjective norms. Second, this study will assess the direct effect of learning experience on social cognitive factors for a specific green product. Third, this study will assess the direct effect of social cognitive factors on intention purchasing behavior. Finally, this study will assess the role of green marketing as a moderating variable for the relationship between intention and purchasing behavior. Data used in this study were primary data, which were collected through closed questionnaires with a five-point Likert scale. This study succeeded in obtaining 602 valid data from the results of filling out questionnaires by participants. This study uses the partial least square (PLS) method with SmartPLS 3.0 for data processing. The result of data processing indicated that outcome expectation, self-efficacy, and subjective norms had significant positive effects on purchase intention for green personal care products. This study also found that the learning experience influenced both outcome expectation and self-efficacy. Although weak, the learning experience was influenced by demographic factors and contextual factors. The demographic factors that affect learning experience were gender and level of education. The contextual factor has a more substantial influence on learning experience in developing consumption-related attitudes to green personal care products than the demographic factor. Finally, this study also found the direct effect of intention on actual purchase behavior and the positive role of green marketing as the moderating variable.
Psychometric Characteristics and Sociodemographic Adaptation of the Corrigan Agitated Behavior Scale in Patients With Severe Mental Disorders
Authors: Garrote-Cámara María Elena , Santolalla-Arnedo Iván , Ruiz de Viñaspre-Hernández Regina , Gea-Caballero Vicente , Sufrate-Sorzano Teresa , del Pozo-Herce Pablo , Garrido-García Rebeca , Rubinat-Arnaldo Esther , Juárez Vela Raúl
Published: December 2021

Background: Severe mental disorder (SMD) is understood in a first approximation as a disorder of thought, emotion, or behavior of long duration, which entails a variable degree of disability and social dysfunction. One of the most widely used assessment scales for agitated behavior, in its English version, is the Corrigan Agitated Behavior Scale (ABS); several studies have demonstrated solid psychometric properties of the English version, with adequate internal consistency.

Objective: The objective of this study was to evaluate the psychometric properties of the Spanish version of the ABS Corrigan scale, in a sample of patients with severe mental disorders. The psychometric analyses of the Spanish version of the ABS Corrigan included tests of the reliability and validity of its internal structure.

Results: The structure of the factorial loads of the analyzed elements is consistent with the hypothesized three-dimensional construction referred to in the original ABS. The results suggest that the reliability and validity of the three dimensions are acceptable (First 0.8, Second 0.8, and Third 0.7). The internal consistency of the Spanish version of the complete ABS and of each of the three domains that compose it is high, with values very close to those found in the original version, with approximate figures of 0.9.

Conclusion: In our study, the three domains aim to explain 64.1% of the total variance of the scale, which exceeds the 50% found in the original version.
Influence of Parental Psychological Flexibility on Pediatric COVID-19 Vaccine Hesitancy: Mediating Role of Self-Efficacy and Coping Style
Authors: Wang Yongyi , Zhang Xinping
Published: December 2021

Background: Pediatric COVID-19 vaccine hesitancy hinders the establishment of immune barrier in children. Psychological flexibility may be a key contributing factor to pediatric COVID-19 vaccine hesitancy, and self-efficacy and coping style play an important role in the relationship, but the underlying mechanisms remain unknown.

Methods: A cross-sectional study was conducted on parents from June 2021 to July 2021. A total of 382 parents were recruited for an online-investigation. Serial mediation models were used to examine whether self-efficacy and coping style mediated in the psychological flexibility-pediatric COVID-19 vaccine hesitancy linkage.

Result: Psychological flexibility was negatively related to pediatric COVID-19 vaccine hesitancy (r = −0.198, P < 0.001). Coping styles rather than self-efficacy played a mediating role independently (95% CI: −0.263 to −0.058). Serial mediation analyses indicated that self-efficacy and coping style co-play a serial mediating role in the association of psychological flexibility and pediatric COVID-19 vaccine hesitancy (95% CI: −0.037 to −0.001).

Conclusion: The present study showed that high psychological flexibility, high self-efficacy, and positive coping style were conducive to the lower pediatric COVID-19 vaccine hesitancy.
Loneliness, Circulating Endocannabinoid Concentrations, and Grief Trajectories in Bereaved Older Adults: A Longitudinal Study
Authors: Kang Minhi , Bohorquez-Montoya Luisa , McAuliffe Timothy , Claesges Stacy A. , Blair Nutta-On , Sauber Garrett , Reynolds Charles F. , Hillard Cecilia J. , Goveas Joseph S.
Published: December 2021

Background: Loneliness is one of the most distressing grief symptoms and is associated with adverse mental health in bereaved older adults. The endocannabinoid signaling (ECS) system is stress-responsive and circulating endocannabinoid (eCB) concentrations are elevated following bereavement. This study examined the association between loneliness and circulating eCB concentrations in grieving older adults and explored the role of eCBs on the association between baseline loneliness and grief symptom trajectories.

Methods: A total of 64 adults [grief with high loneliness: n = 18; grief with low loneliness: n = 26; and healthy comparison (HC): n = 20] completed baseline clinical assessments for the UCLA loneliness scale. In grief participants, longitudinal clinical assessments, including the Inventory of Complicated Grief and 17-item Hamilton Depression Rating scales, were collected over 6 months. Baseline circulating eCB [N-arachidonoylethanolamine (AEA) and 2-arachidonoylglycerol (2-AG)] concentrations were quantified in the serum using isotope dilution, liquid chromatography-mass spectrometry; cortisol concentrations were measured in the same samples using radioimmunoassay.

Results: Circulating AEA concentrations were higher in severely lonely grieving elders than in HC group; cortisol concentrations were not different among the groups. Cross-sectionally, loneliness scores were positively associated with AEA concentrations in grievers; this finding was not significant after accounting for depressive symptom severity. Grieving individuals who endorsed high loneliness and had higher 2-AG concentrations at baseline showed faster grief symptom resolution.

Conclusions: These novel findings suggest that in lonely, bereaved elders, increased circulating eCBs, a reflection of an efficient ECS system, are associated with better adaptation to bereavement. Circulating eCBs as potential moderators and mediators of the loneliness-grief trajectory associations should be investigated.
MagNet: Detecting Digital Presentation Attacks on Face Recognition
Authors: Agarwal Akshay , Singh Richa , Vatsa Mayank , Noore Afzel
Published: December 2021

Presentation attacks on face recognition systems are classified into two categories: physical and digital. While much research has focused on physical attacks such as photo, replay, and mask attacks, digital attacks such as morphing have received limited attention. With the advancements in deep learning and computer vision algorithms, several easy-to-use applications are available where with few taps/clicks, an image can be easily and seamlessly altered. Moreover, generation of synthetic images or modifying images/videos (e.g. creating deepfakes) is relatively easy and highly effective due to the tremendous improvement in generative machine learning models. Many of these techniques can be used to attack the face recognition systems. To address this potential security risk, in this research, we present a novel algorithm for digital presentation attack detection, termed as MagNet, using a “Weighted Local Magnitude Pattern” (WLMP) feature descriptor. We also present a database, termed as IDAgender, which consists of three different subsets of swapping/morphing and neural face transformation. In contrast to existing research, which utilizes sophisticated machine learning networks for attack generation, the databases in this research are prepared using social media platforms that are readily available to everyone with and without any malicious intent. Experiments on the proposed database, FaceForensic database, GAN generated images, and real-world images/videos show the stimulating performance of the proposed algorithm. Through the extensive experiments, it is observed that the proposed algorithm not only yields lower error rates, but also provides computational efficiency.
Menstrual Equity Initiatives at USA Universities: A Multiple Case Study of Common Obstacles and Enabling Factors
Authors: Gruer Caitlin , Goss Taylor , Schmitt Margaret L. , Sommer Marni
Published: December 2021

Background: In recent years there has been growing momentum in the USA around addressing issues of “menstrual equity” and “period poverty,” including a proliferation of university-level initiatives seeking to provide access to free menstrual products. This multiple case study examined four such efforts at a diversity of tertiary institutions to identify the factors that facilitated or impeded success.

Methods: We conducted a qualitative multiple case study, including a desk review and key informant interviews with student and administrative actors from universities with free menstrual product initiatives. We sought to identify key learning regarding common challenges and obstacles, enabling factors which supported success and sustainability, and practical learning for future initiatives. From the desk review, four schools (n = 4) were purposively selected to represent a range of geographic regions, student population size, and university type. Purposive sampling was used to identify students and administrators engaged in the menstrual equity initiatives on each campus (n = 20; 4–6 per school). Data from the desk review and interviews were analyzed using thematic analysis.

Results: Key themes included (1) the critical role of champions, (2) the importance of social and financial support, (3) challenges diffusing menstrual equity from pilot to scale, and (4) recommendations for future initiatives. University initiatives varied greatly in terms of their scope, funding, and implementation strategy.

Conclusion: This multiple case study provides valuable insights regarding the facilitating factors and obstacles faced by initiatives providing free menstrual products at universities. To date, these initiatives have proven successful across the four case studies; however, in most cases, the scope of the initiatives was constrained by limited resources and sustainability concerns. Future campus menstrual equity strategies would benefit from cross-institutional learning and dialogue highlighting design and implementation successes and challenges.
Social Presence as a Moderator of the Effect of Agent Behavior on Emotional Experience in Social Interactions in Virtual Reality
Authors: Pfaller Michael , Kroczek Leon O. H. , Lange Bastian , Fülöp Raymund , Müller Mathias , Mühlberger Andreas
Published: December 2021

Background: Exposure therapy involves exposure to feared stimuli and is considered to be the gold-standard treatment for anxiety disorders. While its application in Virtual Reality (VR) has been very successful for phobic disorders, the effects of exposure to virtual social stimuli in Social Anxiety Disorder are heterogeneous. This difference has been linked to demands on realism and presence, particularly social presence, as a pre-requisite in evoking emotional experiences in virtual social interactions. So far, however, the influence of social presence on emotional experience in social interactions with virtual agents remains unknown.

Objective: We investigated the relationship between realism and social presence and the moderating effect of social presence on the relationship between agent behavior and experienced emotions in virtual social interaction.

Methods: Healthy participants (N = 51) faced virtual agents showing supportive and dismissive behaviors in two virtual environments (short interactions and oral presentations). At first, participants performed five blocks of short one-on-one interactions with virtual agents (two male and two female agents per block). Secondly, participants gave five presentations in front of an audience of 16 agents. In each scenario, agent behavior was a within subjects factor, resulting in one block of neutral, two blocks of negative, and two blocks of positive agent behavior. Ratings of agent behavior (valence and realism), experience (valence and arousal), and presence (physical and social) were collected after every block. Moderator effects were investigated using mixed linear models with random intercepts. Correlations were analyzed via repeated measures correlations.

Results: Ratings of valence of agent behaviors showed reliable relationships with experienced valence and less reliable relationships with experienced arousal. These relationships were moderated by social presence in the presentation scenario. Results for the interaction scenario were weaker but potentially promising for experimental studies. Variations in social presence and realism over time were correlated but social presence proved a more reliable moderator.

Conclusion: Our findings emphasize the role of social presence for emotional experience in response to specific agent behaviors in virtual social interactions. While these findings should be replicated with experimental designs and in clinical samples, variability in social presence might account for heterogeneity in efficacy of virtual exposure to treat social anxiety disorder.
Promoting Healthier Masculinities as a Suicide Prevention Intervention in a Regional Australian Community: A Qualitative Study of Stakeholder Perspectives
Authors: Trail Katherine , Oliffe John L. , Patel Deepa , Robinson Jo , King Kylie , Armstrong Gregory , Seidler Zac , Walton Courtney C. , Wilson Michael J. , Rice Simon M.
Published: December 2021

Regionally-based Australian men have a higher risk of suicide than those in urban centers, with similar trends observed internationally. Adopting a place-based approach to understanding men’s suicide and harm prevention provides contextual insights to guide localised opportunities for the development of tailored gender-specific interventions. Men in rural Australia are typically portrayed as embodying idealized masculinity–dominant and tough, upholding strength and stoicism in the face of hardship. Such values can increase suicide risk in men by reducing help-seeking. The Macedon Ranges Shire is an inner regional municipality with a population of approximately 50,000 people spanning across 10 regional towns and surrounding farming areas in Victoria, Australia. Understanding the influence of masculinities on men’s wellbeing and help seeking behaviours in a regional context is vital in order to inform effective local suicide prevention efforts. The present research involved in-depth qualitative interviews with 19 community stakeholders (M = 49.89 years, SD = 11.82) predominantly working in healthcare and community services including emergency services and education. Using thematic analysis, interview transcripts were coded and themes inductively derived. Stakeholders identified three key areas for understanding suicide risk and wellbeing for local men; 1) localizing masculinities, 2) belonging in community, and 3) engaging men. Findings illustrate that addressing men’s wellbeing in regional areas requires a multifaceted whole-of-community approach. While diverse, local expressions of masculinities were seen as contributors to men’s challenges understanding their emotional worlds and reticence for help-seeking. Of vital need is to provide diverse opportunities for men to connect with others in the region, and offer inclusive spaces where men feel accepted, welcomed and able to meaningfully contribute to the community. Not only will this assist by bolstering men’s sense of self, identity, and mental wellbeing, it may also provide valuable informal inroads to normalizing healthy communication around mental health and seeking mental health care. These findings offer important suggestions for the promotion of healthier masculinities in regionally-based Australian men, which may help to improve wellbeing of these men and their entire communities.
Artificial Intelligence and Machine Learning in Sport Research: An Introduction for Non-data Scientists
Authors: Chmait Nader , Westerbeek Hans
Published: December 2021

In the last two decades, artificial intelligence (AI) has transformed the way in which we consume and analyse sports. The role of AI in improving decision-making and forecasting in sports, amongst many other advantages, is rapidly expanding and gaining more attention in both the academic sector and the industry. Nonetheless, for many sports audiences, professionals and policy makers, who are not particularly au courant or experts in AI, the connexion between artificial intelligence and sports remains fuzzy. Likewise, for many, the motivations for adopting a machine learning (ML) paradigm in sports analytics are still either faint or unclear. In this perspective paper, we present a high-level, non-technical, overview of the machine learning paradigm that motivates its potential for enhancing sports (performance and business) analytics. We provide a summary of some relevant research literature on the areas in which artificial intelligence and machine learning have been applied to the sports industry and in sport research. Finally, we present some hypothetical scenarios of how AI and ML could shape the future of sports.