bluuebunny/crossref_metadata_2025 huggingface dataset:
3D Trimming, The Free angle coloured 2D alternative for Mitral and Aortic Valve
Authors: Elgamal Hany R.
Published: January 2024

One of the enhancement capabilities of modern software are the Trimming
function, which we suggest in this letter to be used in step-by-step
assessment of the Mitral valve (MV) and aortic valve (AV) . it didn’t
overcome the required experience in loop acquisition and enhancement,
but it makes interpretation a lot easier and allow for directly
identification of the pathology in mitral valve leaflet. In Aortic valve
it allows to directly assess the coaptation between the leaflets
including the coaptation between the non-coronary and left coronary
cusps which cannot be obtained even by biplane examination because of
the horizontal cutting line in the Midesophageral aortic valve shorty
axis view.
Foley balloon catheter versus oral misoprostol for induction of labour after PROM: a retrospective data analysis.
Authors: Bouwknegt Anna , Jongen Sjuul , Kamphorst Kim , Linden Paul van der , Pampus Maria van , Zwart Joost
Published: January 2024

Objective. The Foley balloon catheter (FC) is a viable method for
cervical ripening, but concerns about infection risk restrict its use in
cases of prolonged prelabour rupture of membranes (PROM). This study
aims to evaluate the efficacy and safety of the FC compared to oral
misoprostol for cervical ripening after PROM. Design. A retrospective
data-analysis. Setting. Two Dutch teaching hospitals. Population. 128
pregnant women underwent cervical ripening after ≥ 24 hours of PROM at
37-42 weeks’ of gestation. Main outcome measures. The incidence of
intrapartum infection, as a composite of maternal and neonatal
infection. In addition, we evaluated the mode of delivery, duration of
priming and priming-to-delivery interval. Results. The incidence of
intrapartum infection was higher in the FC group compared to oral
misoprostol, respectively 32.7% (n = 16) vs. 12.7% (n = 10) (p =
.006). However, after adjusting for epidural anaesthesia and
pregestational BMI, the association was no longer significant. No
difference was found in mode of delivery. The total priming-to-delivery
interval was similar in both groups (median 21.3 hour vs. 22.0, p =
.897). The duration of cervical ripening was shorter in the misoprostol
group and duration of active labour longer (p <.001).
Conclusion. In women who require cervical ripening after prolonged PROM
at term, FC and oral misoprostol are similar in terms of efficacy and
safety. Funding. The authors received no financial support.
SIMULATION OF OZONE CONCENTRATIONS INSIDE CO60 INDUSTRIAL IRRADIATOR
Authors: gamel amal el , Noaman ali
Published: January 2024

The motivation of this work is to study the link between radiation and
ozone concentration in CO60 industrial irradiators. due to the fact
ozone is one a number of the primary vital problems of safety, as it’s a
negative impact on the health and contains a corrosive effect on metal
components in the irradiated area. furthermore, because of its excessive
reactivity. So first using the ozone monogram method to measure ozone
concentration, and also the impact of the factors on ozone attention
make up my thoughts. Use MATLAB code to calculate the ozone
attention-reaction with absolutely specific records. amongst them, ozone
concentration within the CO60 irradiation area is in a really completely
distinctive country. these situations include: different gamma
resources, absolutely one-of-a-kind irradiators, airflow correction, and
breakdown. it’s suggested that ozone formation may be a detail in the
state of ionizing radiations the feasible health dangers from the ozone
produced throughout irradiation shouldn’t be disregarded.
Clinical relevance of type 2 inflammation as a driver of multi-organ disease: A Delphi consensus initiative
Authors: Björnsdóttir Unnur Steina , Deleuran Mette , Janson Christer , Makela Mika , Porsbjerg Celeste , Toppila-Salmi Sanna , Aanæs Kasper , Agner Tove , Ahlbeck Lars , Altraja Alan , Bjermer Leif , Bradley Maria , Cardell Lars Olaf , Dahlén Sven-Erik , Eyerich Kilian , Hedlin Gunilla , Huldt-Nystrøm Theis , Jørstad Stein Øyvind , Kankaanranta Hannu , Karjalainen Jussi , Korhonen Laura , Lehtimäki Lauri , Mandelin Johanna , Remitz Anita , Sonesson Andreas , Steinsvåg Sverre , Thomsen Simon Francis , Ulrik Charlotte , Vestergaard Christian , Thyssen Jacob
Published: January 2024

Background: This initiative aimed to elucidate the clinical
relevance of type 2 (T2) inflammation as a driver of asthma, atopic
dermatitis, chronic rhinitis, chronic rhinosinusitis with nasal polyps
(CRSwNP) and eosinophilic esophagitis. Methods: A steering
committee (SC) conducted a non-systematic literature search to inform
the design of a Delphi questionnaire including 23 consensus statements,
which was circulated to 30 experts including the SC. Experts rated their
agreement with each statement on a 9-point Likert scale and provided
optional feedback that was used to develop a second Delphi
questionnaire. On 22 October 2020, a meeting was held to discuss the
conclusions from the questionnaires and explore how this initiative may
impact the management of patients with T2 inflammation-driven disease.
Post meeting, a consensus statement on the role of T2 inflammation in
eosinophilic esophagitis was circulated to the experts.
Results: It was agreed that T2 inflammation may be an
underlying driver of asthma, atopic dermatitis, chronic rhinitis, CRSwNP
and eosinophilic esophagitis, and that the published evidence suggests
that these diseases overlap. Some of this overlap may include related
multimorbid conditions driven by T2 inflammation. Thus, in patients with
multiple T2 inflammation-driven diseases, a cross-speciality approach is
warranted to provide effective care. A question guide with input from
relevant experts was proposed, to identify comorbidities and facilitate
appropriate holistic patient management. Conclusions: These
consensus recommendations should be used as a framework to further
understand the extent of T2 inflammation-driven multi-organ disease and
to improve the holistic management and care of these patients.
Case report: A rare presentation of cardiac sarcoidosis with recurrent large pericardial effusion and stress-induced cardiomyopathy
Authors: Naguib Ayman , Qasim Riyadh , Alkatout Khalid , Qaddoura Fatema
Published: January 2024

A 65-year-old female known to have type 2 diabetes mellitus, with no
significant past medical history, had presented to another hospital with
progressive dyspnea, orthopnea, lower limb edema in the two weeks
preceding the reporting of this case. Her echocardiography revealed
large pericardial effusion with echocardiographic signs of increased
intrapericardial pressure. An emergency pericardiocentesis was
performed. One week afterwards, she was admitted to the authors’
hospital because of re-accumulation of her large pericardial effusion,
which mandated another pericardiocentesis. A CT of the chest revealed
enlarged mediastinal lymph nodes (LNs). Video-assisted thoracic surgery
(VATS) was done to obtain a pericardial window and a biopsy from the
mediastinal LN, which revealed non-caseating granuloma, highly
suggestive of sarcoidosis. A few days after surgery she experienced a
neurogenic bladder, acute renal shutdown, and metabolic acidosis, during
which she developed stress-induced cardiomyopathy that improved a few
days later. The patient’s symptoms improved after receiving
corticosteroids.
The Minus-End-Directed Kinesin OsDLK Shuttles to the Nucleus and Modulates the Expression of Cold-Box Factor 4
Authors: Xu Xiaolu , Hummel Sabine , Harter Klaus , Kolukisaoglu Üner , Riemann Michael , Nick Peter
Published: January 2024

The transition to terrestrial plants was accompanied by a progressive
loss of microtubule minus end-directed dynein motors. Instead, the
minus-end directed class-XIV kinesins expanded considerably, probably
related to novel functions. One of these motors, OsDLK (Dual
Localisation Kinesin from rice) decorates cortical microtubules but
moves into the nucleus in response to cold stress. This analysis of
loss-of-function mutants in rice indicates that OsDLK participates in
cell elongation during development. Since OsDLK harbours both, a nuclear
localisation signal, and a putative leucin zipper, we asked, whether the
cold-induced import of OsDLK into the nucleus might correlate with a
specific DNA binding. Conducting a DPI-ELISA screen with recombinant
OsDLKT (lacking the motor domain), we identified the Opaque2 motif as
most promising candidate. This motif is present in the promoter of
NtAvr9/Cf9, the tobacco homologue of Cold Box Factor 4, a transcription
factor involved in cold adaptation. A comparative study revealed that
the cold-induced accumulation of NtAvr9/Cfp9 was specifically quelled in
transgenic BY-2 cells overexpressing OsDLK-GFP. These findings are
discussed as a working model, where, in response to cold stress, OsDLK
partitions from cortical microtubules at the plasma membrane into the
nucleus and specifically modulates the expression of genes involved in
cold adaptation.
Taxane therapy associated adverse ocular reactions
Authors: Ye Ya-Ting , Zhou Zi-yi , Wen Li-Shi , Sun Yu , chu zhaojie , Dou Guo-rui
Published: January 2024

The adverse ocular reactions to paclitaxels involve a series of damage,
which can be observed on ocular surface, ocular appendages and
intraocular tissues. They can appear as various clinical symptoms
including dry eye, lacrimal duct obstruction, conjunctivitis, keratitis,
macular edema, retinal injury, optic nerve injury, and etc. All these
symptoms may lead to irreversible visual loss. The mechanisms of these
side effects are still unclear. Macular edema, one of the side effects,
may be related to the dysfunction of retinal pigment epithelial (RPE)
cells and Müller cells which is caused by paclitaxel, while other
symptoms may be caused by the cytotoxicity of paclitaxels. In this
review, we describe the widely accepted drug-induced ocular disorders
and the possible mechanisms, so as to provide some suggestions for the
monitoring and management of ocular toxicity.
Ultrasound imaging of the hypoglossal nerve: tools and techniques
Authors: Culevski Kahte , Ezeokeke Chikodi , Nyguyen Cynthia , Sahota Annika , Kelly Cory , Kwon Younghoon , Weaver Edward , Mourad Pierre
Published: January 2024

Abstract Objectives: The hypoglossal nerve (HN) represents an important
stimulation target for treating obstructive sleep apnea. Here, we
demonstrate use of diagnostic ultrasound to identify and track the HN,
including its distal branches. Methods: Standard ultrasound imaging,
supplemented with Doppler ultrasound, was used on five participants to
identify the HN from its proximal aspect adjacent to the carotid artery
to its branching in the submandibular space. Participants were between
the ages of 21-25 and were imaged at the University of Washington.
Results: We successfully imaged and tracked the HN, including the main
distal branches, and identified relevant landmarks in all five
participants. We observed the greatest variance in HN structure near the
mandibular branch point, as well as variable manifestation of the first
cervical spinal nerve. Conclusion: Diagnostic ultrasound, with Doppler,
can identify and track the HN, including to its distal branches. This
technique may improve surgical planning for head and neck procedures
including the placement of stimulation devices for the HN.
An LSTM-Autoencoder Architecture for Anomaly Detection Applied on Compressors Audio Data
Authors: Mobtahej Pooyan , Zhang Xulong , Hamidi Maryam , Zhang Jing
Published: January 2024

Anomaly detection for the compressor systems is essential for the
midstream industry. In this paper, anomaly classification and detections
method based on neural network hybrid model named as Long Short-Term
Memory (LSTM)-Autoencoder (AE) is proposed to detect anomalies on
sequence pattern of audio data, collected by multiple sound sensors
deployed at different components of each compressor system. To create a
baseline for model evaluation this paper has also conducted experiments
on different RNN architectures such as GRU, LSTM, Stacked LSTM and
Stacked GRU with different functions. Each architecture used audio
signals dataset received from the compressor system for experiments to
consider the performance in each neural network model. All the network
architectures and experiment results have considered with various model
configuration and layers with different functions. According to
performance results, optimal model for anomaly detection with best
performance scores has proposed in this research. In conducted
experiments, combined one-dimensional raw audio signals features using
SC and Mel spectrogram features were fed to deep learning models to
evaluate performance. Using SC and Mel spectrogram features achieved the
best performance for anomaly detection in audio data based on the
LSTM-AE in all evaluation metrics. Hence such hybrid methods can detect
normal and anomaly audio signals collected from a compressor system
effectively, which can increase the compressor reliability and the gas
production line sustainability.
Does Ostomy Lead to Worse Outcomes in Ovarian Cancer after Bowel Resection? A Meta-analysis and Systematic Review
Authors: He Xinlin , Li Zhengyu
Published: January 2024

Background: Debulking cytoreduction surgery with bowel resection is a
common intervention for ovarian cancer. Whether an ostomy should be
performed remains controversial. Objectives: We performed a
meta-analysis and systematic review to determine whether ostomy leads to
poorer outcomes for ovarian cancer after bowel resection than
anastomosis. Search Strategy: We searched PubMed Medline, Embase, and
Cochrane for articles containing the phrase “ovarian cancer with bowel
resection,” published between 2016 and 2021. Selecting Criteria: We
included studies that compared primary anastomosis with ostomy. We
mainly focused on differences in anastomotic leakage (AL) rate and some
survival outcomes between the two procedures. Data Collection and
Analysis: Review Manager V5.3 was used to analyze all studies. Main
Results: Of all 763 studies, three were ultimately included in the
meta-analysis (N=1411). Results showed that ostomy might not have more
adverse events of Grade III and above (according to the Clavien–Dindo
grade) ([Odds ratio] (OR) 1.04 (95% CI [0.82,1.33]). Moreover,
ostomy might not increase AL(OR 1.07 (95% CI [0.30,3.87]). We have
supplemented the systematic review to include analysis of those data
which can not be analyzed by meta-analysis. Conclusion Ostomy may not
result in more AL, but may lead to worse survival outcomes than
anastomosis. However, patients with a more severe ovarian cancer status
may be more prone to ostomy rather than primary anastomosis. Funding:
This work was supported by the Sichuan Province Science and Technology
Support Program (grant number 2019YJ0072). Keywords: Ostomy, Ovarian
Cancer, Bowel Resection, Meta-analysis, Systematic Review
Not all coronaries need an angiogram - The importance of pre-catheterisation echocardiography in acute myocardial infarction
Authors: Velayutham Ramanathan , Parale Chinmay , Kumar Ritesh , Anantharaj Avinash
Published: January 2024

In acute myocardial infarction (AMI), transthoracic echocardiography is
usually used to look for regional contraction abnormalities, to assess
the extent of ventricular dysfunction and for diagnosis of mechanical
complications. An early coronary angiogram is the established norm and
echocardiographic coronary imaging is usually not a part of the routine
management protocol. We describe a case of a young male with acute
myocardial infarction secondary to right coronary cusp thrombosis which
was diagnosed on a transthoracic echocardiogram. This case aims to
highlight the importance of incorporating echocardiographic coronary
imaging in routine practice prior to a coronary catheterization.
Management of beta-lactam antibiotics allergy: a real-life study
Authors: Comte Denis , Iuliano Sarah , Senn Laurence , Moi Laura , Muller Yannick , Ribi Camillo , Buss Guillaume
Published: January 2024

Background: Beta-lactam antibiotics are the most frequent drug
family to cause allergic reactions. Herein, we examined the frequency of
confirmed allergies to beta-lactam, as well as the sensitivity and
negative predictive value (NPV) of skin testing in an adult population
referred to a university allergy clinic in Switzerland.
Methods: This is a retrospective analysis of the clinical
records of patients who were investigated for a label of allergy to
beta-lactam (penicillin, cephalosporin or carbapenem) between January 1
2011 and December 31 2018.
Results: 582 patients were identified with a documented allergy
to beta-lactam and 477 patients were systemically investigated by skin
tests and/or drug challenge to confirm or rule out allergy. 262 patients
reported a history of immediate reactions, 137 of delayed reactions, and
114 of unknown reactions. 88 (18.4%) patients had confirmed to any
beta-lactam antibiotics; 64 (13.4%) with an immediate- and 24 (5%)
with a delayed-type reaction. Most frequently identified allergy was
penicillin (65 patients), followed by cephalosporin (21 patients) and
carbapenem (2 patients). NPV of skin tests for all beta-lactam were
97.7% and 92.5% for immediate- and delayed-type reactions,
respectively, and 96.3% and 92.1% when only penicillin was considered.
Systemic allergic reaction occurred in 0.6% of skin tests and in 3.1%
of drug challenges. Conclusions: Only 18% of patients with
beta-lactam allergy label have a confirmed allergy and non-allergic
patients can be safely delabelled through allergic workup based on skin
tests and drug challenge. This approach supports the policy of saving
second-line antibiotics through systemic allergy work-up.
IMMUNOLOGY IN EMERGENCY MEDICINE: TETRAHYDROCANNABINOL AND COCAINE ABUSE INDUCES NEUTROPHILS AND CD19 + B-CELL EXPANSION
Authors: Albanesi Marcello , Chaoul Nada , Zurlo Marco , Monitillo Francesco , Pedote Pasquale , Procacci Vito
Published: January 2024

cocaine and tetrahydrocannabinol (THC)-containing drugs
(marijuana/hashish) are the most frequently used recreational drugs.
Both these molecules exert their main function in the central nervous
system (CNS), due to their capability to trespass the blood-brain
barrier [1] [2]. Once in the CNS, cocaine acts by inhibiting the
re-uptake of serotonin, norepinephrine and dopamine, while
tetrahydrocannabinol act as partial agonist of the cannabinoid receptor
CB1 [1] [2]. Aside the action on CNS little is known about the
effects of these recreational drugs on the immune system. [3]
[4] We describe herein a case of a 31-year old man, non-drug addict,
that abused for the first time of both cocaine and THC and was admitted
in the Emergency room for acute confusional state and increase in
heartbeat. We stabilized the patient’s clinical condition and analyzed
the changes in the immune compartment.
Encapsulating IM7-displaying yeast cells in calcium alginate beads for one-step protein purification and multienzyme biocatalysis
Authors: Yin Wenhao , Wang Xinping , Chen Lixia , Ma Lixin , Qiao Jie , Liu Yi
Published: January 2024

Though there are several commercial chromatographic systems for protein
purification, development of cost-effective 3H-grade (high activity,
high purity, and high activity) purification approaches is highly
demanded. Here, we establish a methodology for encapsulating the
IM7-displaying yeast cells in calcium alginate beads. Taking advantage
of the biomaterial-based affinity chromatography, cost-effective
purification of proteins with over 90% purity in a single-step is
achieved. Moreover, our system is applied to coat multienzyme complex,
leading to reusable biomaterials for high-efficient biocatalysis. Taken
together, the present method has great application potential not only in
the laboratory but also in industry for production of protein products.
Behind XRCC1 Arg399Gln polymorphism: protection factor of laryngeal cancer
Authors: Firigato Isabela , Curioni Otavio , Antonio Juliana , Silva Mariana , Gattás Gilka , Goncalves Fernanda
Published: January 2024

Laryngeal cancer is the second most common head and neck cancer
worldwide, which has been considering a serious global health problem
due to the high morbidity and mortality. Tumour risk factors include the
DNA repair gene polymorphisms, but their contribution for metastasis
and/or second primary tumour development has been seldom investigated.
Objective (s): The present study evaluated the possible association
between the DNA repair gene polymorphisms and laryngeal cancer risk,
metastasis and/or second primary tumour in a hospital-based case-control
study that comprised 149 laryngeal cancer patients and 448 controls from
Heliópolis Hospital, São Paulo, Brazil. Design: The single nucleotide
polymorphisms (SNPs) of the genes XRCC1 (Arg194Trp; Arg399Gln), XPD
(Lys751Gln) and XRCC3 (Thr241Met) were analysed by TaqMan SNP Genotyping
Assays. Results: The heterozygous genotype (OR 0.63, 95% CI 0.41-0.96)
as well as the mutated homozygous genotype (OR 0.29, 95% CI 0.13-0.66)
of XRCC1 (Arg399Gln) decreased the laryngeal cancer risk, even though
none of the genes polymorphisms was associated with metastasis and/or
second primary tumour development. Conclusion: The determination of the
XRCC1 (399Gln) genotype might be applied as a molecular predictor of
laryngeal cancer among individuals who are highly exposed to cigarette
smoking carcinogens and improve the prognostic of the disease.
Lung ultrasound an alternative to computed tomography and chest X-ray in the diagnosis of children infected with SARS-CoV-2: a systematic review of literature
Authors: Wang Xiali , Huang Tingting , Lyu Guorong
Published: January 2024

Abstract Background: Lung ultrasound (LUS) has become an important tool
in diagnosing and following an adult patient with COVID-19; however, the
literature for the pediatric age group is limited. Herein, we reviewed
the up-to-date literatures on ultrasound use for COVID-19 pediatric
patients for better management of COVID-19 in children. Methods and
Objectives: The search terms “COVID-19,” “SARS-CoV2,”
“coronavirus,” “2019-nCoV,” “lung ultrasound,” “sonography,”
“adolescents” “children,” “childhood” and “newborn” were
searched on the online databases PubMed, Embase and Medline. Articles
meeting the inclusion criteria were included in the analysis and review.
Results: We identified only fifteen studies to date using LUS to
diagnose SARS-CoV-2 infection in children. These studies involved a
total of 334 newborns, children and adolescents. Regarding the use of
chest X-ray (CXR) and LUS in pediatric patients with COVID-19, we
identified six studies with a total of 162 participants, with the
following results: 33patients(14.11%) with lung abnormalities on lung
US had a normal CXR; however, no patients with normal lung US had
abnormalities on the CXR. In addition, regarding the use of computed
tomography (CT) and LUS in pediatric patients with COVID-19 infection,
we identified five studies with a total of 50 participants and 3
patients(6%) with lung abnormalities on chest LUS had a normal CT.
Conclusion: Our findings suggest that LUS is a useful tool in the
diagnosis of children and reduction in chest CT assessments may be
possible when LUS is used in early diagnosis and follow-up monitoring of
COVID-19 pneumonia in the children.
Critical analysis of DNA extraction techniques: yield, quality, time, cost, and plastic usage
Authors: Gordon Jessica , Taylor Michelle
Published: January 2024

Using non model-organisms is becoming increasingly common in NGS.
Different NGS techniques have different demands of DNA extraction;
abundant DNA, “clean” HMW DNA, to be cheap, to be quick, and
increasingly considered, to use minimal plastics. Here we compare five
DNA extraction methods: a phenol-based extraction, salting-out protocol,
and three commercially available kits from Qiagen: Blood and Tissue Kit,
Plant Mini kit, and PowerSoil Pro kit. These protocols were tested
across non-model organisms: deep-sea octocorals and scleractinians. We
included four individuals from each of the octocorals, Acanella
arbuscula, Paragoria sp., and Pennatula sp., as well as four individuals
from each of the scleractinian corals, Madrepora oculata, Lophelia
pertusa, and Desmophyllum dianthus. DNA yield and quality were measured
and compared across methods. Phenol yielded the most DNA per mg of
tissue across all corals except Acanella and Madrepora- where
salting-out yielded the most DNA. The Qiagen Plant Mini kit produced the
highest ratio of HMW DNA to degraded DNA in all corals tested. The
purity of DNA (measured by absorbance) was equal across methods. The
amount of plastic used for each protocol was also measured with kit DNA
extractions using significantly more plastics than non-kit protocols. We
also make recommendations on how to reduce future plastic usage.
Overall, it was found that recovering HMW DNA across extraction methods
was genus specific, and the method used by researchers should take into
account their specific research needs.
Assessing adherence to inhaled therapies in asthma and the emergence of electronic monitoring devices
Authors: Dhruve Hetal , Jackson David
Published: January 2024

Infrequent use of inhaled corticosteroids (ICS) and/or over-reliance of
short-acting beta agonists (SABA) are recognised as key contributors to
increased morbidity and mortality in asthma. The most frequent measures
of ICS adherence and SABA use relies on patient reported questionnaires
or prescription refill records, neither of which are considered
sufficiently reliable. Technological advancements in the development of
electronic monitoring of inhaler devices allow for monitoring of use, as
well as recording and feedback of inhaler technique for some devices.
Most electronic monitoring devices (EMDs) are paired with a smartphone
application, allowing patients to set reminders and display both
preventer and reliever use over time. This allows identification of
intentional and unintentional ICS non-adherence as well as frequency of
SABA use. This information assists clinicians in distinguishing
difficult-to-control from severe asthma. Although cost currently limits
widespread use, the introduction of EMDs into the asthma armoury is a
significant step-forward in asthma care and has the potential to improve
asthma related outcomes.
Left Atrial Appendage Thrombus Extraction Guided by Real Time Transesophageal Echocardiography: A Simple Solution to a Complex Problem
Authors: Bhagat Rohun , Ziazadeh Daniel , Wyrobek Julie , Knight Peter
Published: January 2024

Intra-operative discovery of left atrial appendage (LAA) thrombus on
transesophageal echocardiography (TEE) poses a dilemma. While LAA
thrombi are classically managed medically, leaving a thrombus in a
patient undoubtedly increases the risk for life-altering stroke.
Additionally, medical management with anticoagulation increases risk for
hemorrhagic complications. Direct appendage incision and thrombus
extraction under TEE guidance followed by appendage clip closure
provides a simple, elegant solution to this complex problem.
Circulation and seasonality of influenza viruses in different transmission zones in Africa from 2013-2019
Authors: Belizaire Marie Roseline Darnycka , Kouabenan Anderson N'Gattia , Wassonguema Bibata , Rafaï Clotaire , Nakoune Emmanuel , LÔ Baidy , Bolumar Francisco
Published: January 2024

Background The Influenza Viruses are responsible for more than 5 million
of severe cases and 290,000 to 650,000 deaths every year worldwide.
Developing countries support 99% of deaths caused by Influenza in
children under age of 5. This paper aims to determine the dynamics of
influenza viruses in African transmission areas identifying regional
seasonality for appropriate decision making and development of regional
preparedness and response strategies. Methods We used data from the
fluMart website collected by Influenza national programmes for seven
period of transmission (2013-2019). We calculate weekly proportions of
positive influenza cases and follow the trend of the transmission in
countries in the Africa continent to determine the circulation and
seasonality. Results AH1N1 is the predominated influenza A circulated in
all the African areas of transmission. In 2016, the A(H3N2) virus was
only supplanted in North Africa. The Yamagata lineage B virus, which had
been circulating in West Africa until this period, has reappeared in
Southern and Eastern Africa. In 2019, a proportional co-circulation of
pandemic A(H1N1) 2009 and A(H3N2) influenza viruses is detected in
eastern and central Africa. Conclusions The influenza viruses
circulating in Africa are the same in the other continents. They
generate various epidemic periods during the year. Epidemic season
extends from May to August in the southern zone while it extends from
August to April in northern zone. In the tropical band of the African
continent, the influenza seasons start in the East and end in the West.
Key words: Influenza surveillance, Africa, circulation, saisonality
Investigation of the Effects of N-Linked Glycans on the Stability of the Spike Protein in SARS-CoV-2 by Molecular Dynamics Simulations
Authors: TEKİN E.Deniz
Published: January 2024

We perform all-atom molecular dynamics simulations to study the effects
of the N-linked glycans on the stability of the spike glycoprotein in
SARS-CoV-2. After a 100 ns of simulation on the spike proteins without
and with the N-linked glycans, we found that the presence of glycans
increases the local stability in their vicinity; even though their
effect on the full structure is negligible.
Enhanced reduction of CO2 to CH4 by novel mesoporous Ru-Fe3O4/CeOx-SiO2 catalyst in a fixed bed reactor
Authors: Roy Shyamal , Mondal Dilip
Published: January 2024

A novel mesoporous Ru-Fe3O4/CeOx-SiO2 (Ce3+/Ce4+, x=1.64) catalyst was
synthesized via excess solution impregnation of Ru and Fe3O4
nanoparticles (NPs) on ceria-loaded mesoporous SBA-15. The reduction of
CO2 to methane was performed in the presence of H2 over the catalyst in
a fixed bed reactor. CO2 reduction was found to be 82% at 0.25 wt%
ruthenium loading, 2.5 wt% iron loading, 573 K temperature, 20 bar
pressure, 3000 mL.g.-1. h-1 gas hour space velocity and H2 to CO2 mole
ratio of 5:1. The close contact between ruthenium and Fe3O4
nanoparticles facilitated the reduction of CO2 through hydrogen
spill-over effect and ceria NPs acted as a promoter for reduction
reaction. The catalysts were characterized thoroughly using CO
chemisorption, BET, TPR, TPD, XRD, SEM, HR TEM, ICP-AES and XPS
techniques. Optimal process conditions could render much higher CO2
conversion efficacy for selective methane synthesis in comparison with
previous scientific investigations.
RSM optimization of biodiesel production by a novel composite of Fe(ΙΙΙ)-based MOF and phosphomolybdic acid
Authors: Nikseresht Ahmad , Parak Soraya , Alikarami Mohammad Alikarami , Ghasemi Saba
Published: January 2024

The synthesis of MIL-53 samples and encapsulation process of
phosphomolybdic acid implemented using ultrasound at ambient temperature
and atmospheric pressure. Analysis of the results showed that H3PMo
salts have strong electrostatic interactions with the iron (III)
lattice, which play an important role in reducing leaching from the
compound. Characterization of newly synthesized nanocomposite was
carried out using various techniques such as XRD, FT-IR, SEM, BET and
ICP. The catalytic activity of the prepared nanocomposites,
PMA@MIL-53(Fe), was tested through the esterification reaction of oleic
acid with methanol under ultrasonic irradiation. Biodiesel production
process using certain molar ratio of oleic acid/methanol, PMA@MIL-53(Fe)
as catalyst (50-200 mg) containing different amounts of PMA (0-40%), at
different reaction times (5-25 minutes) and ambient temperature under
ultrasound conditions was optimized using CCD tab of Design Expert
software. The results indicated that the synthesized composites show
excellent catalytic activity.
The relationship between the burden of care and fear of disease progression in mothers of children with cystic fibrosis
Authors: Shoghi Mahnaz , Mohamadi Somayeh , Modaresi Mohammadreza , Goudarzi Somayeh Moazami
Published: January 2024

Introduction: The burden of care and fear of disease progression is
noticeable in mothers of children with cystic fibrosis. Hence, this
study was done with the aim to determine the relationship between the
burden of care and fear of disease progression in mothers of children
with CF. Method: 142 mothers of children with CF participated in this
correlational study. Data were collected with the sequential method. The
-The self-report Zarit burden of care and fear of disease progression
questionnaires were Used. Results: According to the results, the mean
maternal burden of care was 34.12 ± 69.77, and the mean fear of disease
progression was 32.12 ± 92.11. The burden of care had the highest
regression effect on fear of disease progression in mothers of children
with CF (β = 0.896). With an increase of one unit of standard deviation
in the burden of care, an increase of 0.896 units occurred in fear of
disease progression in parents of children with CF. Discussion: Mothers
of children with CF experience a moderate burden of care and fear of
disease progression. An increase in the burden of care and psychological
stress increases the fear of disease progression in these mothers. It is
recommended that healthcare providers, especially nurses, consider the
conditions of this group of mothers due to the burden of care and
long-term fear of disease progression and plan and implement appropriate
care interventions.
A nomogram prediction model for recurrence risk of atrial fibrillation patients after radiofrequency ablation
Authors: Ruan Zhong-bao , Liang Hong-xia , Wang Fei , Chen Ge-cai , Zhu Jun-guo , Ren Yin , Zhu Li
Published: January 2024

Introduction: The recurrence of atrial fibrillation (AF) after single
radiofrequency ablation (RFCA) is high, there were few relevant studies
focusing on the construction of the prediction model for AF recurrence
after RFCA. Methods and Results：A total of 221 patients with AF who
underwent RFCA were enrolled. Univariate and multivariate Cox regression
were used to screen the predictors of recurrence. Receiver operating
characteristic (ROC) curve and Kaplan-Meier (K-M) curve were drawn to
analyze the value of predictors. The nomogram model was further
constructed to predict the recurrence of AF in patients after RFCA. As
results, there were 59 cases of AF recurrence after RFCA. Monocyte
count/high-density lipoprotein cholesterol (MHR), AF course (COURSE),
coronary heart disease (CHD) and AF type (TYPE) were the independent
risk factors for predicting AF recurrence after RFCA. Accordingly, a
nomogram prediction model based on MHR, COURSE, CHD and TYPE was
constructed with a C-index of 0.818 (95%CL=0.681, 0.954), while C-index
of verification was 0.802 (95%CL=0.658, 0.946).
Conclusion：Preoperative MHR, COURSE, CHD and TYPE were independent risk
factors for predicting recurrence of AF after RFCA. The nomogram model
based on MHR, COURSE, CHD and TYPE can be used to predict the recurrence
of AF after RFCA accurately and individually.
Treatment Outcomes of Unilateral Retinoblastoma in Japan - A Single-Center Retrospective Study of 153 Eyes
Authors: Shirakawa Nami , Arakawa Ayumu , Nakajima Miho , Tanimura Kazuki , Tao Kayoko , Watanabe Yuko , Sugiyama Masanaka , Ogawa Chitose , Suzuki Shigenobu
Published: January 2024

Background: Although conservative treatment has been used for unilateral
retinoblastoma, enucleation is still the mainstay of treatment for the
ICRB D–E group. In Japan, conservative treatment has been performed to
preserve the eyes of patients with unilateral retinoblastoma including
group D–E. We analyzed the data of patients treated at our institution
with the aim of assessing if conservative therapy in the D–E group
would worsen the survival outcomes and if it would also enable
preservation of visual acuity. Procedure: We retrospectively reviewed
medical records of patients of unilateral retinoblastoma from January 1,
2006, to December 31, 2015. Survival rates, EBRT-avoided preservation
rates, and safety were analyzed for the initially enucleated and
conservative treatment groups. Results: Among 153 patients, 34 (89%) in
the B–C group and 49 (43%) in the D–E group underwent conservative
treatment, respectively. 36 out of 83 (43%) patients were able to avoid
enucleation without EBRT by undergoing conservative treatment. In the
D–E groups with conservative treatment, there were extraocular
recurrences in two patients, and one patient who had a CNS recurrence
died. The 5-year OS and RFS was 97.9 (95%CI : 85.8–99.7)% and 95.8
(95%CI : 84.3–98.9)% in the D–E group, respectively. There were no
acute serious adverse events during conservative treatment, and no
secondary malignancies were observed. Conclusion: Conservative treatment
for unilateral retinoblastoma, including for the D–E groups is
acceptable based on the results that OS remained high and no serious
adverse events were observed.
Impact of Hall current and Joule heating on a rotating hybrid nanofluid over a stretched plate with nonlinear thermal radiation
Authors: elsaid essam , AlShurafat khalid
Published: January 2024

The impact of magnetic field, joule heating, rotation parameter, Hall
current, with nonlinear thermal radiation, on a rotating hybrid
〖Fe〗_3 O_4/〖Al〗_2 O_3 nanofluid over-stretched plate is the
focus of this research. Using similarity transformations, the
controlling partial differential equations are turned into a set of
nonlinear ordinary differential equations. For that system of equations,
the shooting method is used to generate numerical solutions. The impact
of various entry parameters on transversal and longitudinal velocities,
temperature, heat flow and surface shear stress are studied numerically
and graphically.
Robust dissipativity and passivity of stochastic Markovian switching CVNNs with probabilistic time-varying delay and partly unknown transition rates
Authors: Li Qiang , Gong Weiqiang , Zhang Linzhong
Published: January 2024

This paper is devoted to the robust dissipativity and passivity problems
for Markovian switching complex-valued neural networks with
probabilistic time-varying delay, where the transition rates are partly
unknown, which might reflect more realistic dynamical behaviors of the
switching networks. The probabilistic delay is described by a sequence
of bernoulli distributed random variables, and mode-dependent parameter
uncertainties are assumed to be norm-bounded. Based on the complex
version of the generalized It$\hat{o}$’s formula, the
robust analysis tools and the stochastic analysis methods, some
sufficient mode/delay-dependent criteria on the
$(M,N,W)$-dissipativity and passivity are derived in terms of complex
matrix inequalities. In the end of paper, two numerical examples are
presented to illustrate the effectiveness and feasibility of the
obtained results.
Energy Preserving Reduced-Order Modeling of The Rotating Thermal Shallow Water Equation
Authors: KARASÖZEN Bülent , UZUNCA Murat , YILDIZ Süleyman
Published: January 2024

In this paper, reduced-order models are developed for the rotating
thermal shallow water equation (RTSWE) in the non-canonical Hamiltonian
form with the state-dependent Poisson matrix. The high fidelity full
solutions are obtained by discretizing the RTSWE in space with
skew-symmetric finite-differences, that preserve the Hamiltonian. The
resulting skew-gradient system with the skew-symmetric Poisson matrix is
integrated in time by the energy preserving average vector field (AVF)
method. The reduced-order model (ROM) is constructed in the same way as
the full-order model (FOM), preserving the reduced skew-symmetric
structure and integrating in time with the AVF method. Applying proper
orthogonal decomposition (POD) with the Galerkin projection, an energy
preserving ROM is constructed. The nonlinearities in the ROM are
computed by applying the discrete empirical interpolation (DEIM) method
to reduce the computational cost. The computation of the reduced-order
solutions is accelerated further by the use of tensor techniques. The
overall procedure yields a clear separation of the offline and online
computational cost of the reduced solutions. The accuracy and
computational efficiency of the ROMs are demonstrated for a numerical
test problem. Preservation of the energy (Hamiltonian), and other
conserved quantities, i.e., mass, buoyancy, and total vorticity show
that the reduced-order solutions ensure the long-term stability of the
solutions while exhibiting several orders of magnitude computational
speedup over the FOM.
Adaptive finite-time command filtered control for switched nonlinear systems with input quantization and output constraints
Authors: Cheng Fabin , Wang Huanqing , Zong Guangdeng , Niu Ben , Zhao Xudong
Published: January 2024

This article considers the problem of finite-time command filtered
control for switched nonlinear systems with input quantization and
output constraints. The unmeasurable state is estimated by designing a
switched state observer. During the design process, to overcome the
chattering problem effectively, the hysteresis quantization is designed
as two bounded nonlinear functions. Furthermore, in order to restrict
the output to an expected range, the barrier Lyapunov function (BLF)
approach is introduced. The “explosion of complexity” (EOC) and the
error compensation problems in the backstepping design are solved by
using a finite-time command filtered (FTCF) approach. A first-order
Levant differentiator (FLD) is used instead of the general command
filter in this paper, which cannot only filter the intermediate signals
accurately to get the differential signals, but also ensure the
finite-time stability of the filter. Stability of the closed-loop system
in the sense of semi-global practical finite-time stability (SGPFS) is
proved by exploring a multiple Lyapunov functions approach. Finally, a
simulation example is provided to verify the validity of the presented
control method.
CLASSIFICATION OF MAMMOGRAPHIC IMAGES BY OPENVINO: A PROPOSAL OF USE TO ENHANCE MORE EFFECTIVITY IN CANCER DIAGNOSIS
Authors: Jr Horacio Lucca , Jr. Arnaldo Santos
Published: January 2024

Computer vision is the way to teach machines intelligence so that they
are able to see things exactly like humans, is what allows computers to
see and process visual data just like humans. Computer vision involves
analyzing images to produce useful information (BARELLI, 2018). Images
from mammograms of breast nodules were analyzed and a method of
classification by shape and texture was proposed using computer programs
that can maximize the accuracy in the assertive diagnosis of the
malignancy or not of a tumor, that is, a tool that could be useful as a
contribution in interpreting the results to mastologists who identify
such nodules through the analyzed radiological images. The DDMS (digital
database for screening mammography) was used to train an artificial
intelligence program, OpenVino.
A p(x)-Kirchhoff type problems involving the p(x)-Laplacian-like operators with Dirichlet boundary conditions
Authors: Ouaarabi Mohamed El , Allalou Chakir , Melliani Said
Published: January 2024

This paper deals with a class of $p(x)$-Kirchhoff type problems
involving the $p(x)$-Laplacian-like operators, arising from the
capillarity phenomena, depending on two real parameters with Dirichlet
boundary conditions. Using a topological degree for a class of
demicontinuous operators of generalized $(S_{+})$ type and the
theory of the variable exponent Sobolev spaces, we prove the existence
of weak solutions of this problem.
A Glimpse at Cell Nucleation
Authors: Dinçer Pervin Rukiye , Düz Niloufar Boustanabadimaralan
Published: January 2024

Nucleus (plural nuclei) is the Latin term for the central organelle of
eukaryotic cells. While the building blocks of eukaryotic cells (humans,
plants and amoebas) feature command centers containing DNA, prokaryotes
(Eubacteria and Archaebacteria) do not. This membrane-bound nucleus has
played an indispensable role in the diversification of today’s
multicellular life, and the uncertainty surrounding its evolution has
long been a puzzle for scientists studying the evolution of modern
organisms. Emergence of the nucleus and our own origin are quite
interlinked. Over the years, the subject of the origin of the eukaryotic
nucleus has been discussed in depth by microbiologists, evolutionary
biologists, cell biologists, etc., and even though the subject has
brought many biologists together, their studies continue to produce
different perspectives of the birth of the nucleus. We discuss here
primarily theories arguing for the prokaryotic or viral origin of the
nucleus, but also investigate reductive theory which suggests that the
origin of the nucleus dates back to the last universal common ancestor
(LUCA), and that prokaryotes are a product of reductive evolution.
Finally, we take a brief glance at the domain cell theory of life
supporting the LUCA as the origin of the nucleus.
The long-coherent-time and potentially scalable qubits composed of electric dipolar molecules based on graphene
Authors: Huang Yongyi
Published: January 2024

We propose a new kind of qubits composed of electric dipolar molecules.
The electric dipolar molecules in an external uniform electric field
will take simple harmonic oscillations, whose quantum states belonging
to the two lowest energy levels act as the states
|0>,|1> of a qubit. The
qubits’ excited states have a very long mean life time more than 70ms.We
can perform quantum computations by manipulating the qubits of electric
dipolar molecules just like those of neutral atoms. When the qubits are
used for quantum computations, the dipolar moments’ orientations will
harmonically oscillate along an external electric field and they will
not change the directions: along or against the electric field, so the
qubits can be large-scalely manufactured in graphene system.
Cystine adsorption on Cu9 cluster : A DFT study
Authors: Bhadoria Poonam , RAMANATHAN VENKATNARAYAN
Published: January 2024

A density functional theory (DFT) approach was used to investigate the
interaction of cystine with Cu9 cluster at B3LYP/LANL2DZ/6-311++G(d,p)
level of theory. It was observed that cystine interacts with copper
cluster majorly through its disulfide and –COOH groups. The simulated
Raman spectrum confirmed the cleavage of disulfide linkage by the
disappearance of the –S-S- stretching mode, in good agreement with the
earlier reported experimental study. As noted by the peaks observed due
to Cu-S and Cu-O stretching mode in the simulated Raman spectrum,
cystine is inferred to have chemisorbed on Cu9. Using NBO analysis, it
was revealed that oxygen and sulfur donate electron pairs to copper in
the Cu9-cystine system. Additionally, the MK[ESP] charge and FMO
analysis supported the above mentioned results significantly.
Comparison the effects of propidium iodide and 7-aminoactinomycin-D in the presence or absence of RNase on cell cycle analysis using flow Cytometry
Authors: Li Chenchang , Yao Weicheng , Wang Yongqiang , Deng Weixi , Peng Jiangyun
Published: January 2024

Objective: To explore the difference between PI and 7-AAD nucleic acid
dyes on the detection of cell cycle experiments and the effect of RNase
with the staining of the two dyes by flow cytometer. Method: Using
ModFit LT 4.1.7 software analyse cell cycle data and assess the effects
of the two different dyes and RNase on cell cycle results. Coloring of
cell lines HCCLM3, HepG2 and HEK293T by PI or 7-AAD, with or without RNA
digestion, respectively. Results: Only the colouring of the PI cell
cycle has a significant effect on by RNase, but the 7-AAD cell cycle
does not. For RNase-treated samples, PI staining to detect the cell
cycle is more precise than 7-AAD staining to detect the cell cycle.