bluuebunny/crossref_metadata_2025 huggingface dataset:
Estudo de três casos alóctones de leishmaniose visceral canina em Jaboticabal, São Paulo, Brasil
Authors: Lima Gabriela Piovan , Favaro Ana Beatriz Botto de Barros da Cruz , Ramos Fernanda Ramalho , Gouveia Bethânia Almeida , Bertolo Paulo Henrique Leal , Miotto Mariana Rodrigues , Carvalho Adolorata Aparecida Bianco , Vasconcelos Rosemeri de Oliveira
Published: March 2024

A leishmaniose visceral (LV) é uma antropozoonose global que afeta humanos, cães e animais silvestres. O cão é considerado o principal reservatório urbano da doença, causada pelo protozoário Leishmania infantum e transmitida pela picada do vetor Lutzomyia longipalpis. A infecção pode ser assintomática ou sintomática, apresentando alterações que incluem anemia, caquexia, febre, linfadenomegalia, esplenomegalia e hepatomegalia, lesões cutâneas e onicogrifose. O diagnóstico ocorre por meio da pesquisa direta ou indireta do parasita em amostras de sangue, lesões cutâneas, fígado, baço, aspirado de linfonodo e medula óssea. Este estudo descreve três casos de LV em cães oriundos de Pirajuí e importados para Jaboticabal, SP, Brasil. Os diagnósticos foram confirmados por testes clínicos, sorológicos, moleculares e parasitários, destacando variações nos resultados. A necessidade de múltiplos métodos diagnósticos é enfatizada devido às diferentes manifestações da doença. O artigo também ressalta a importância do controle do trânsito de cães entre regiões para evitar a disseminação da LV, sugerindo medidas de prevenção e controle para áreas não endêmicas.
Tendências e Perfil Epidemiológico das Intoxicações Exógenas no Estado do Pará: Análise de uma Década
Authors: Victor Oliveira de Souza João , Antonio Rodrigues Mendes Erick , De Seixas Moura Esther , Lucas Farias Lima Igor , Augusto de Melo Sales José , Leão Gaia Stefanie , Sakai neto Suehiko , Oliveira Yasmim Lisboa de , Neder Patricia Regina Bastos
Published: March 2024

Introdução: Intoxicação exógena é uma síndrome causada pela ingestão ou contato com substâncias tóxicas. Possui uma série de etiologias diferentes e relevante importância principalmente em situações de acidentes e tentativas de suicídio. A correta técnica semiológica é essencial para se identificar os variados aspectos clínicos e pessoais que envolvem situações de intoxicação, assim como informações a respeito do perfil epidemiológico mais afetado. Objetivo: avaliar a incidência e a prevalência de casos de intoxicação exógena no estado do Pará no período de 2012 a 2021. Metodologia: Trata-se de um estudo epidemiológico descritivo, transversal, com abordagem quantitativa e retrospectiva dos casos de intoxicações exógenas no Estado do Pará, com base em dados secundários obtidos por meio do Sistema de Informação de Agravos de Notificação. Resultados: O estudo evidenciou um aumento na incidência de intoxicações exógenas no período estudado. Foram notificados 5849 casos, sendo o perfil mais comum sexo feminino, faixa etária 20 a 39 anos, cor/raça parda, sendo os medicamentos os agentes tóxicos mias utilizados e as tentativas de suicídio as circunstâncias mais prevalentes. Conclusão: Conclui-se a grande relevância das intoxicações exógenas em casos tentativa de suicídio, tornando necessária políticas de prevenção na área. Porém, o grande número de notificações com variáveis ignoradas ou em branco, prejudicam a construção de uma estratégia de combate.
The role of the Russian Academy of Sciences in the study of respiratory health and development of pulmonology in the Far East of Russia
Authors: Kolosov V. P. , Perelman J. M. , Polyanskaya E. V. , Manakov L. G.
Published: March 2024

The establishment of the Federal State Budgetary Scientific Institution «Far Eastern Scientific Center for Physiology and Pathology of Respiration» is examined within the historical progression of academic science in the Russian Far East and the Russian Academy of Sciences' contribution to this development, commemorating its 300th anniversary in Russia. The outcomes of medical science and healthcare contributions to pulmonology advancement in the Far Eastern region are evaluated.
The effect of drugs used in the treatment of hemoblastosis on the morphofunctional state of spermatozoa
Authors: Abramkin E. E. , Menshikova N. V. , Makarov I. Y.
Published: March 2024

Introduction. The relevance of the study is due to the high frequency of complications after the use of drugs for treating malignant tumors, which is associated with the cytotoxic effect of chemotherapy drugs both on malignancy sites and on healthy tissues, including the cells of male gonads.

Aim. To study the impact of drugs intended for the treatment of hemoblastoses on the total sperm count, their mobility, and the presence of pathological forms under experimental conditions.

Materials and methods. A case-control study was conducted on 18 male rats aged 90 days. The control group consisted of male rats that did not receive hemoblastosis treatment drugs, and the second group was intraperitoneally injected with cyclophosphamide, hydroxydaunorubicin, vincristine, prednisolone (hereinafter referred to as CHOP). Mature spermatozoa were obtained from the dissected appendages of the testes, by opening them on a thermal stage. The contents of the rat's seminiferous tubules, in a volume of 0.02 ml, were diluted in 0.4 ml of 0.9% sodium chloride solution, preheated to 37°C. The total, absolute, and relative number of spermatozoa in a unit volume (0.4 ml) of epididymal suspension was counted, taking into account their mobility according to the generally accepted system. Actively mobile and weakly mobile were attributed to the fertile fraction, and "twitching" and immobile - to the infertile fraction of epididymal spermatozoa. Then, the fertility index was calculated, which represents the ratio of the number of fertile forms to infertile ones. To determine the viability of spermatozoa, their count with regard to mobility was conducted within the first hour every 15 minutes, and subsequently every 30 minutes until the complete cessation of all spermatozoa. To assess the pathological forms of spermatozoa, the absolute and percentage content of spermatozoa in a unit volume (0.4 ml) of epididymal suspension with defects in the head, neck, midpiece, and tail was counted under light microscopy.

Results. The experimental exposure to CHOP group drugs had the following effects: a decrease in the total number of spermatozoa by 37% was observed in the male rats of the experimental group, accompanied by an increase in the number of their pathological forms by 26% compared to the control group.

Conclusion. The increased risk of infertility, caused by the toxic effect of drugs intended for the treatment of hemoblastoses, is associated with a decrease in the total number of spermatozoa and an increase in pathological forms, leading to a reduction in the number of mobile cells.
PROCEDURES FOR CARRYING OUT BIOLOGICAL CONTROL MEASURES AGAINST OWLET MOTHS IN THE POTATO BIOTOPE OF THE AGROBIOCENOSIS OF KARAKALPAKSTAN
Authors: Toreniyazov E.Sh  , Rozimova A.P
Published: March 2024

The results of the studies conducted on the types, bioecology of pests that cause damage to potato varieties grown in Karakalpakstan and biological control measures against them are presented.
KEY WORDS: Plant, variety, seedling, harvest, pest, rodents, owlet moths, biology, dynamics, trichogram, biological usefulness.
Efektivitas Trauma Healing Dalam Mengurangi Trauma Psikologis Pada Korban Kecelakaan Bus Pariwisata di Pagar Alam Tahun 2023
Authors: Hanifah Abu , Rahma Zanjabila
Published: March 2024

The World Health Organization (WHO) states that there are as many as 1.25 million victims of traffic accidents every year, and 20-50 million people face injuries due to traffic accidents. Accidents have an impact that can be felt on the human body, such as physical injuries that result in trauma to the individual. This accident is a symptom of trauma which affects the brain's memory that it interferes with a person carrying out daily activities, such as always being alert. In this study, the sample taken experienced trauma due to a tourist bus accident because the accident resulted in physical disability and disrupted daily activities. The sample felt anxious and remembered the bus accident every night. This research aims to reduce the subject's psychological trauma due to the tourist bus accident by applying Al-Quran Murotal Therapy. The method in this research is a One Shot Case Study Design Experimental research (One Case Design) meaning it consists of one group that is given treatment (Murotal Al-Quran Therapy) then observes the symptoms that occur, then conclusions are drawn. The application of Al-Quran murotal therapy in this research was carried out routinely 2 times a day for 26 weeks. From the subject's 26-week journey in applying Murotal Al-Quran therapy, researchers saw that the journey in physical and mental healing were in line with rational thinking.

Keywords - Accidents, Psychological Trauma, Murotal Al-Quran.
Índice Integrado de Governança e Gestão Pública em Universidade
Authors:   Ana Lúcia de Medeiros, de Oliveira Andrade Alexandre Antonio ,   Darlene Teixeira Castro,   Eduardo Andrea Lemus Erasmo,   Nilton Marques de Oliveira,   Sonia Maria Moreira de Sousa
Published: March 2024

O objetivo principal desta obra é explorar as bases conceituais da governança pública, analisar as produções científicas voltadas para esse campo e apresentar uma abordagem específica utilizada no estudo. A partir da exploração das diretrizes de governança da Universidade Federal do Tocantins (UFT) e da identificação das forças, fraquezas, ameaças e oportunidades relacionadas à governança, o livro desenvolve um instrumento de orientação para a governança pública da Universidade Estadual do Tocantins (Unitins).
Influence of rehabilitation with the use of sulphide and hydrogen sulphide baths on the concentration of the brain-derived neurotrophic factor (BDNF) and selected parameters of cognitive, executive and affect functions in multiple sclerosis patients
Authors: Gniadek-Olejniczak Katarzyna , Jozwik-Plebanek Katarzyna , Smolinski Rafał , Kania-Pudło Marta , Mróz Józef
Published: March 2024

Aim: To compare the blood serum BDNF concentration in MS patients before and after a standard three-week rehabilitation offered by the NHF. The study compared the expected growth of the BDNF concentration in a group of patients rehabilitated with the help of standard kinesiotherapy and a group of patients rehabilitated with kinesiotherapy plus sulphide and hydro sulphide baths as well as the results of the assessment of the cognitive and executive functions of MS patients in the two groups.
Materials and methods: Participants in the study were divided into 3 groups of 20 people each. Group 1. MS patients rehabilitated for 3 weeks in the Day Ward of the Rehabilitation Clinic – standard kinesiotherapy. Group 2. MS patients rehabilitated for 3 weeks in the Day Ward of the Rehabilitation Clinic – kinesiotherapy with sulphide baths. Group 3. Healthy volunteers – occasional BDNF determination. In the group of MS patients the BDNF concentration was determined prior to and after the rehabilitation. Group 3 was monitored for BDNF levels initially lower than in MS patients.
Results: Rehabilitation of MS patients with kinesiotherapy and sulphide baths causes a statistically higher growth of BDNF concentration than rehabilitation alone in this group of patients (p<0.001). Results of neuropsychological tests of MS patients rehabilitated with kinesiotherapy and balneotherapy elements are statistically better than of patients rehabilitated with kinesiotherapy (p<0.033).
Conclusions: Research findings show that sulphide and hydro sulphuric baths seem to be a valuable supplement to MS patients’ rehabilitation.
Minat AL - Rahman interpretation (Indeed these are tow magicians) from his saying the Most HIgh (They said 'Indeed these are two magicians') surah Taha verse 62
Authors: Fatima Mhar
Published: March 2024

This text consists of seven sections:
Section 1: Determining the Disputed Letter.
Section 2: Attribution of the Dispute.
Section 3: Enumeration of the Dispute.
Section 4: Directing the Dispute.
Section 5: Arranging the Dispute.
Section 6: Liberating the Dispute.
Section 7: Drawing the Disputed Letter.
The fourth section is considered the nucleus of this research, and its purpose is to direct the attention of readers to the disagreement regarding the verse from Surah Taha: "They said, 'Indeed, these are two magicians.'" The readers' variations in this verse are related to four aspects: the disagreement between strengthening and softening the letter "nun" in "Indeed," the difference in pronunciation of "these two," and the softening and strengthening of the letter "nun" in "these two."
The Hafs reading, as narrated by Asim, is considered the most accepted among Arab scholars and is a consensus among the various Quranic manuscripts. However, Abu Amr's reading differs from the commonly agreed-upon scriptural pronunciation, making it a challenging reading for grammarians. The research establishes the correctness of Abu Amr's reading and asserts that there is no objection to it. It also highlights the multiple interpretations and enriching meanings brought about by the emphasis on "Indeed" and the inclusion of the letter "alif" in "these two," providing more nuances than any non-controversial reading.
The research employs an analytical approach to analyse the ongoing disagreement surrounding this contentious reading from the perspective of grammarians. It's important to note that direction and protest are subsidiary to the establishment of the reading, not its essence. For instance, the reading "They said, 'Indeed, these are two magicians'" is firmly established in terms of the authenticity of its narration and its multiple transmissions. However, different opinions exist regarding the justification for each reading, and none is free from objections.
It is worth noting the thoroughness of this research in addressing this letter. I did not find any researcher who had specifically analysed and explained it, except for a research paper I came across, written by Rabia Zannoun Yunus Al-Malla, titled "(His statement, 'Indeed, these are two magicians') [Taha: 62] - Reading and Direction." Since it is just a research paper published in a journal and not a comprehensive and meticulous academic study, I found that there is still ample room for further exploration of this letter, gathering its scattered aspects from language books, interpretations, directions, readings, and explanations of some poetic compositions.
Factors and indicators for evaluating the effectiveness of land resource management at agrarian enterprises
Authors:   State Biotecnological University, POLTAVETS Anatolii
Published: March 2024

The article substantiates the composition of factors and indicators for evaluating the effectiveness of land resource management at agrarian enterprises. Indicators of the effectiveness of land resources use at agrarian enterprises have been determined. Factors influencing the effectiveness of land resource management at agrarian enterprises are substantiated, dividing them into external and internal. It was established that indicators of the effectiveness of land resource management should be sufficiently standardized, which requires the selection of areas that can be divided into the following groups: social group, ecological group, economic group, institutional (legal) group. It has been outlined that the main criteria for effective land use at agrarian enterprises are obtaining production results sufficient for the expanded reproduction of advanced capital in the form of produced volumes of agrarian products, provided that the agro-ecological condition of agrarian lands is improved or at least not deteriorated and the landowners achieve an appropriate level of income. Changes in the legal regulation of the economic circulation of agrarian land have a significant impact on the achievement of economic and other types of effectiveness in the use of land resources. It is substantiated that specific indicators of agrarian production by industry per unit area, indicators of production and total costs for the production of agrarian products, the cost of soil protection and soil conservation measures depending on their composition, the cost of rent and the results of the normative assessment of the value of land plots depend on the production value and soil grading. Keywords: land resources, land use, evaluation, performance indicators, balanced development.
PENERAPAN SISTEM ONLINE DIGITAL SAVING DALAM MENINGKATKAN KEPUASAN NASABAH DI MEDIASI DENGAN KEPUTUSAN MENABUNG (Studi Kasus pada Nasabah PT. BRI Cabang Pelintung Dumai)
Authors: Ibhar Muhalida Zia , Feldiko Ibhar Frinov
Published: March 2024

Penelitian ini bertujuan untuk melihat penerapan Sistem Online Digital Saving Dalam Meningkatkan Kepuasan Nasabah diMediasi dengan Keputusan Menabung. Populasi sasaran penelitian ini adalah para penabung/nasabah aktif PT Bank BRI Cabang Pelintung Dumai. Penelitian ini dilakukan dengan pendekatan penelitian kuantitatif. Populasi pada penelitian ini berjumlah 202 orang dan sampel diambil dengan menggunakan rumus slovin, maka dapat diperoleh jumlah sampel dalam penelitian ini adalah 145 responden. Pengambilan sampling menggunakan teknik random sampling Analisis Data pada Penelitian ini menggunakan analisis data statistik inferensial diukur dengan SEM-PLS. Hasil penelitian menunjukkan bahwa (1) SODS berpengaruh signifikan terhadap keputusan menabung; (2) SODS berpengaruh signifikan terhadap kepuasan nasabah; (3) Keputusan menabung berpengaruh signifikan terhadap kepuasan nasabah.
Challenges and advancements in high-throughput screening strategies for cancer therapeutics
Authors: Roy Ruchi , Singh Sunil Kumar , Ahmad Nashrah , Misra Sweta
Published: March 2024

Drug discovery relies on high-throughput screening (HTS) methods incorporating both target- and cell-based assays. This comprehensive review delves into the challenges and benefits associated with these assays within the context of HTS. The strategies for developing screening assays, spanning both primary and secondary screens for target identification, are discussed. Furthermore, we review the methods of identifying the most efficacious drugs through these approaches for the treatment of cancer in detail. While various drugs have been identified for cancer treatment, there remains a pressing need for more relevant phenotypic assays. These assays aim to produce the desired disease phenotype, with a specific emphasis on highlighting targets rather than off-targets. The ultimate goal is to pave the way for innovative drug development strategies that can effectively treat cancer patients, thereby reducing the mortality rate.
Pengaruh Kualitas Produk terhadap Keputusan Pembelian pada PT. Elco Indonesia Sejahtera
Authors: Syaifuddin Syaifuddin
Published: March 2024

Penelitian ini bertujuan untuk mengetahui pengaruh kualitas produk terhadap keputusan pembelian pada PT. Elco Indonesia Sejahtera. Dengan mengumpulkan data dari 68 responden melalui kuesioner, penelitian ini menggunakan analisis statistik seperti koefisien korelasi, koefisien determinasi, dan uji hipotesis T untuk mengevaluasi dan mengukur hubungan antara variabel kualitas produk dengan keputusan pembelian. Hasil penelitian menunjukkan terdapat hubungan yang signifikan dan positif antara kualitas produk dengan keputusan pembelian. Koefisien korelasi yang tinggi menunjukkan bahwa peningkatan kualitas produk memberikan kontribusi yang kuat terhadap peningkatan keputusan pembelian, begitu pula sebaliknya. Dengan koefisien determinasi sebesar 50,7%, kualitas produk mempunyai pengaruh yang besar terhadap variasi keputusan pembelian konsumen. Uji hipotesis T membuktikan adanya signifikansi positif pengaruh kualitas produk terhadap keputusan pembelian, dengan nilai t hitung jauh melebihi nilai t tabel. Oleh karena itu dapat disimpulkan bahwa kualitas produk berpengaruh positif dan signifikan terhadap keputusan pembelian pada PT. Elco Indonesia Sejahtera. Temuan ini memberikan landasan empiris yang kuat bagi perusahaan untuk fokus pada peningkatan kualitas produk sebagai strategi pemasaran yang efektif. Dengan memahami kuatnya pengaruh kualitas produk terhadap keputusan pembelian, PT. Elco Indonesia Sejahtera dapat merancang langkah-langkah yang lebih tepat sasaran untuk memperkuat posisi mereka di pasar, meningkatkan kepuasan konsumen, dan mencapai pertumbuhan bisnis yang berkelanjutan.
Making Small Talk: Support for Chinese Graduate Students
Authors: Xu Hui
Published: March 2024

This article is based on a larger phenomenological inquiry which examined the challenges faced by Chinese graduate students in Canada when making small talk in English as an additional language. In that study, ten participants were interviewed about their small talk experiences, including the support they expected and received from peers, faculty members, and institutions. This article examines the level of support provided to assist these students engage in small talk with a specific focus on the gap between the help they need and the help they get. The study is theoretically informed by the concept of community of practice which describes how newcomers learn in naturally occurring established communities. It was found that all participants expected and wanted institutional and peer support, but their level of satisfaction with what they received varied. All four universities attended by the research participants offered services designed to help international students, but uptake was a problem. It is recommended that institutions put more effort into developing, promoting, and monitoring programs designed to support international students.
Keywords: small talk, community of practice, Chinese graduate students, support
Kata Kata Hubung sebagai Peranti Kohesi dalam teks Ucapan Tunku Abdul Rahman
Authors: binti Yaakub Yusniza , binti Abd. Mutalib Mashetoh , binti Halim Rohizah
Published: March 2024

Kertas kerja ini meninjau tentang aspek kohesi, khususnya kehadiran kata penghubung dalam teks ucapan Tunku Abdul Rahman, Perdana Menteri Malaysia yang pertama. Kohesi ialah hubungan antara bahagian dalam sesebuah teks yang ditandai oleh penggunaan unsur bahasa yang mengikatnya. Penggunaan teks ucapan Tunku sebagai data kajian dilakukan kerana ada kelompangan dengan kebanyakan kajian lalu lebih memberikan tumpuan terhadap pemikiran, gaya kepimpinan dan gaya bahasa dalam ucapan beliau, namun kurang memberikan tumpuan kepada aspek linguistik. Kajian kualitatif ini menggunakan huraian oleh Nik Safiah et al. (2008) dan Sanat (2002) yang berpaksikan kerangka teori linguistik yang digagaskan oleh Halliday (1975), iaitu nahu fungsional. Nahu fungsional melihat bahasa sebagai bentuk perilaku yang bersifat fungsian, iaitu bahasa digunakan untuk memenuhi tujuan tertentu, serta turut dipengaruhi oleh konteks sosiobudaya penutur. Penggunaan kerangka ini dirasakan wajar kerana kajian ini meneliti penggunaan ayat, serta fungsi dan proses yang dimainkan oleh kata penghubung. Analisis terhadap enam teks ucapan Almarhum Tunku dilakukan dengan menggunakan huraian kata penghubung Nik Safiah et al. (2008) dan Sanat (2002) yang disesuaikan berdasarkan kerangka asas kohesi Halliday dan Hassan (1976, iaitu kata hubung tambahan, pertentangan, sebab dan masa. Dapatan menunjukkan bahawa kata hubung tambahan sebagai jenis kata hubung yang paling produktif dalam data. Hal ini demikian kerana pewacana perlu memberikan maklumat tambahan kepada khalayak bagi menyampaikan ideologi serta hala tuju kepimpinan beliau. Dapatan ini dapat dilihat sebagai bukti bahawa penggunaan bahasa berkait dengan fungsi bahasa yang diperlukan oleh penutur. Hasil kajian diharapkan dapat menambahkan lagi khazanah ilmu linguistik, khususnya bidang analisis wacana dan tatabahasa wacana bahasa Melayu.
Prediction of groundwater contamination in an open landfill area using a novel hybrid clustering-based ai model
Authors: Singh Prachi , Mahor Vikas , Lakshmaiya Natrayan , Shanker Kandukuri , Kaliappan Seeniappan , Muthukannan Muthiah , Rajendran Gopinath
Published: March 2024

Groundwater is a vital resource that provides drinking water to over half of the world’s population. However, groundwater contamination has become a serious issue due to human activities such as industrialization, agriculture, and improper waste disposal. The impacts of groundwater contamination can be severe, including health risks, environmental damage, and economic losses. A list of unknown groundwater contamination sources has been developed for the Wang-Tien landfill using a groundwater modeling system (GMS). Further, AI-based models have been developed which accurately predict the contamination from the sources at this site. A serious complication with most previous studies using artificial neural networks (ANN) for contamination source identification has been the large size of the neural networks. We have designed the ANN models which use three different ways of presenting inputs that are categorized by hierarchical K-means clustering. Such an implementation reduces the overall complexity of the model along with high accuracy. The predictive capability of developed models was assessed using performance indices and compared with the ANN models. The results show that the hybrid model of hierarchical K-means clustering and ANN model (HCA-ANN) is a highly accurate model for identifying pollution sources in contaminated water.
Zbywalność prawa do grobu
Authors: Skoczykłoda Paweł
Published: March 2024

Niniejszy artykuł koncentruje się na analizie prawa do grobu celem ustalenia możliwości jego zbycia. Dzisiejsza nauka prawa jak i orzecznictwo wypracowały koncepcję prawa do grobu jako prawa o charakterze zmiennym i niejednorodnym, stanowiącym wiązkę uprawnień materialnych i niematerialnych. Choć zdaje się ona chronić prawa osobiste bliskich zmarłego, jednak zupełnie nie zabezpiecza uprawnień pierwotnego dysponenta grobu. Co więcej, zgodnie z nią w momencie złożenia do grobu zwłok dochodzi do „rozlania się prawa do grobu”, które odtąd przysługuje szerokiemu kręgowi dysponentów. Skutkuje to tym, że zbywalność prawa do grobu podlega daleko idącym ograniczeniom. Autor proponuje, aby odróżnić prawo do pustego grobu od prawa do grobu, w którym został już ktoś pochowany, gdyż owa dystynkcja wpływa na określenie możliwości zbywalności prawa.
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Collaboration and Destination Marketing: Creating Film-Induced Tourism
Authors: Nakayama Chihiro
Published: March 2024

Increased attention to film tourism processes has driven the need for research on its relevance to destination marketing. Film tourism involves different actors with various interests, often making collaboration challenging. This study aims to understand how film tourism can succeed
within complex processes involving multiple actors by using in-depth semistructured interviews. Using actor-network theory and emphasizing the relational network in the case study of film location bus tours, it shows that human and nonhuman actors, the tourism and film industries, film commissions,
advertising agencies, residents, tourists, ports, and buses interact to create film tourism. This study shows that film tourism networks that were formed successfully are disbanded because of the changing relations between human and nonhuman actors in film tourism. The analysis reveals that
power lies in the network created by collaboration among all actors, and the future of film tourism development relies on how heterogeneity is processed. It critically examines the binary of host and guest in tourism and attempts to transcend it constructively. Theoretically, it extends the
context of how different actors’ interests are effectively processed. This study contributes toward enhancing sustainable tourism by reflecting the nature unique to the region, integrating with films shot in a destination to revitalize the regional economy.
The Role of Branched-Chain Amino Acid (BCAA) Supplementation in Sarcopenia among the Elderly
Authors: Rahaliya Salsabila Fatahuddin  , Niam Syaifun
Published: March 2024

Background: Sarcopenia is a syndrome characterized by loss of skeletal muscle mass, strength, and skeletal muscle function that occurs as a result of aging. To maintain muscle mass, a dynamic balance is needed between muscle protein synthesis (MPS) and its breakdown. BCAAs, including leucine (Leu), isoleucine (Ile), and valine (Val), have been found to have important mediating effects in protein synthesis, glucose homeostasis.

Methods: This literature review aims to explain further the role of BCAAs in sarcopenia.

Results: Numerous studies have demonstrated the advantages of BCAAs for maintaining or improving skeletal muscle mass and performance in both healthy elderly people and those with other comorbidities. It was also shown that resistance training and vitamin D supplementation enhanced the benefits of BCAAs.

Conclusion: There are still study results that contradict the role of BCAAs in sarcopenia, hence more research with homogeneity in supplementation dosage and outcome measurement methods is required in order to obtain stronger evidence to support its claims.
Athari ya Mitindo Mbalimbali ya Breili katika Unukuzi wa Maandishi ya Breili ya Kiswahili
Authors: Mwangi Daniel Mburu
Published: March 2024

Utafiti huu ulinuia kuchanganua usahihi wa unukuzi wa maandishi ya breili hadi maandishi ya kawaida na kinyume chake, ili kuleta maana iliyokusudiwa. Katika kutimiza lengo hilo, utafiti huu umechunguza changamoto au ugumu wanaokumbana nao wanukuzi wa maandishi haya na athari yake kwa wanafunzi wasioona katika elimu. Utafiti wa nyanjani ndio uliofaa kazi hii, nazo mbinu za kukusanya data zilizozofaa ni hojaji na mahojiano. Wanafunzi walipewa kazi ya kuandika insha zilizopewa wanukuzi walizozinukuu ili kuchanganuliwa. Uchunguzi huu ulikusudiwa kufanywa katika vyuo vya elimu kama vile Chuo Kikuu cha Kenyatta, Chuo Kikuu cha Maseno, Taasisi ya Elimu ya Machakos, Taasisi ya Wasioona ya Kenya na Taasisi ya Elimu ya Kagumo kwa sababu vyuo  hivi ndivyo vilivyo na wahadhiri wengi wasiojua kusoma breili na mara nyingi husaidiwa na wanukuzi kunukuu kazi za breili katika maandishi ya kawaida ili wakapate kusoma na kuelewa. Kutokana na utafiti huu ni wazi kuwa tafsiri ya breili ya Kiswahili hadi maandishi ya kawaida imepungukiwa katika kuwasilisha maana iliyokusudiwa kwa sababu ya ukosefu wa breili sanifu ya Kiswahili, kuwepo kwa changamoto zilizofafanuliwa katika tasnifu hii na ukosefu wa umilisi katika breili ya Kiswahili miongoni mwa wanafunzi na wanukuzi huathiri pakubwa tafsiri ya maandishi haya. Utafiti huu utawanufaisha wanaotumia breili, walimu wao na wanukuzi wa maandishi haya ya breili
Pengaruh Rasio Keuangan terhadap Pertumbuhan Laba pada Perusahaan Sub Sektor Makanan dan Minuman yang Terdaftar di Bursa Efek Indonesia Periode 2020-2022
Authors: Sipahutar Cinta Ruth , Gaol Manatap Berliana Lumban , Siboro Danri Toni
Published: March 2024

This study aims to determine the effect of financial ratios on profit growth in food and beverage sub-sector companies listed on the Indonesia Stock Exchange in 2020-2022. The dependent variable in this study is profit growth, the independent variables in this study are Return On Asset, Net Profit Margin, Current Ratio, Debt to Asset Ratio and Total Asset Turnover. The population in this study was 84 companies and the sample used was 30 companies with purposive sampling techniques. The data used in this study is secondary data sourced from the company's financial statements and annual reports. The research method used in this study is quantitative research with multiple linear regression analysis techniques and data processing using the SPSS program version 25. The results of this study show that NPM has a positive and significant effect on profit growth. ROA and CR have a negative and significant effect on profit growth. DAR has a negative and insignificant effect on profit growth, while TATO has a positive and insignificant effect on profit growth.
Pengaruh Sistem Informasi Akuntansi terhadap Kinerja Usaha Mikro Kecil (UMK) di Kecamatan Kabanjahe
Authors: Sinulingga Yosi Delmy Ocha Br , Siahaan Audrey M. , Siboro Danri Toni
Published: March 2024

This research aims to find out what influence accounting information systems have on the performance of Micro and Small Enterprises in Kabanjahe District. The independent variable is the accounting information system, and the dependent variable is performance. The research method used is primary data collection techniques in the form of questionnaires. The sampling method used in this research was Conveience Sampling, with a total sample of 40 respondents. Data processing uses SPSS version 26 tools. Tests used in this research include descriptive statistical analysis, validity and reliability tests, normality tests, simple linear regression, and partial significance tests (t tests). The results of this research show that the Accounting Information System (X) has a positive, significant effect on the performance (Y) of Micro and Small Businesses in Kabanjahe sub-district. Based on the results of the t test, the accounting information system variable has an effect on the performance of micro and small businesses in Kabanjahe sub-district by 0.001 (0.001<0.05).
TYPES OF CRITICAL THINKING IN THE CONTINUOUS TRAINING OF STUDENTS FOR PEDAGOGICAL ACTIVITY
Authors:   Doctoral Student At The Research Institute Of Pedagogical Sciences Of Uzbekistan Named After T.N. Kari Niyazi, Uzbekistan, Otabekovna Gulyamova Aziza
Published: March 2024

The article analyses the types of critical thinking in the continuous preparation of students for professional teaching activity, it is explained that critical thinking is a concept that represents an objective way of thinking, which includes various types of human mental activity.
Child And Adolescent Psychiatric Approaches in Solid Organ Transplantations Manual for Clinicians
Authors: Baskın Esra , Törenli Kaya Zulal , Bacanlı Ali , Kütük Meryem Özlem , Eseroğlu Söylemez Tuğba , Kaba Duygu
Published: March 2024

Historical Background of Pediatric Kidney and Liver Transplantation in Turkey
Mehmet HABERAL
Mental Problems Commonly Experienced in Pediatric Organ Transplantation
Esra BASKIN
The Perspectives of Psychosocial Development and Children Having Chronic Diseases
Zulal TÖRENLI KAYA
Child Psychiatric Assessment and Ethical Issues in Solid Organ Transplantations
Burcu AKIN SARI
Intellectual Disability and Solid Organ Transplantations
Burcu AKIN SARI
Attention Deficit and Hyperactivity Disorder and Organ Transplantations
Ali BACANLI
Autism Spectrum Disorders and Solid Organ Transplantations
Hande AYRALER TANER
Anxiety Disorders and Solid Organ Transplantations
Meryem Özlem KÜTÜK
Mood Disorders and Solid Organ Transplantations
Tuğba ESEROĞLU SÖYLEMEZ
Psychotic Conditions and Solid Organ Transplantations
Hande AYRALER TANER
Approach to Psychopathologies in Children: Recommendations to Clinicians
Duygu KABA
Drugs Commonly Used in Psychopharmacology and Possible Drug Interactions in Solid Organ
Transplant Candidates or Recipients
Duygu KABA
Plastik Sanatlarda Kuramsal Bakış Açılarıyla Resim
Authors: Yıldırım Dila , Kılıç Ahmet Göktuğ , Soylu Rasim , Kızılırmak Çekinmez Buse , Ayan H. Müjde , Atlı Çağatay , Gönülay Çalımlı Zeynep , Öz Çelikbaş Eda , Yalı Fatih , Haykır Mustafa , Vargün Özlem , Keleş Nurgül , Turan Mehmet Erkan , Davun Banu
Published: March 2024

Mimarinin Resim Sanatına Etkisi ve Eserlerinde Mimari Unsur Kullanan Sanatçı Örneklemleri
Fahrettin GEÇEN
Dila YILDIRIM
Dijital Sanatta Oluşturulan Veri Tabanları ve Yapay Zeka Uygulamaları
Ümit PARSIL
Ahmet Göktuğ KILIÇ
Fahrettin Geçen Portrelerinde Rembrandt Işığı Etkisi
Rasim SOYLU
Eserlerinde Taille - Douce Tekniğini Kullanan Sanatçılar
Buse KIZILIRMAK ÇEKİNMEZ
Müjde AYAN
Batı Resim Sanatında Doğu Etkileri: Alfred Julıo Jensen Mural’ın Eserlerindeki Çin Sayı Sisteminin Etkisi
Çağatay ATLI
Erwin Panofsky’nin İkonoloji ve İkonografik Eleştiri Yöntemi Bağlamında Bir Sanatçı Örneği: Ümit Parsıl
Ahmet Göktuğ KILIÇ
Tazminat ve Meşrutiyet Dönemi’nde Resim Eğitimi Veren İlk Kurumlar
Zeynep GÖNÜLAY ÇALIMLI
Yeni Nesnelliğin Doğuşu I. Dünya Savaşı
Eda ÖZ ÇELİKBAŞ
Fatih YALI
Primitif Sanatta Dışavurum ve Bilinçaltının Yaratıcılığı
Mustafa HAYKIR
Antoni Tapies’in Eserlerindeki Yumuşak Güç ve İdeolojik Söylem
Özlem VARGÜN
Tehachapi Kaliforniya Ceza İnfaz Kurumunda Benzersiz Bir Sanat Projesi
Nurgül KELEŞ
Soyut Sanatın Türk Resmine Yansımaları ve Adnan Çoker Örneği
Mehmet Erkan TURAN
Eserlerinde Geleneksel Formları Kullanan Türk Ressamları
Banu DAVUN
Nanomedicines against Chagas disease: a critical review
Authors: Morilla Maria Jose , Ghosal Kajal , Romero Eder Lilia
Published: March 2024

Chagas disease (CD) is the most important endemic parasitosis in South America and represents a great socioeconomic burden for the chronically ill and their families. The only currently available treatment against CD is based on the oral administration of benznidazole, an agent, developed in 1971, of controversial effectiveness on chronically ill patients and toxic to adults. So far, conventional pharmacological approaches have failed to offer more effective and less toxic alternatives to benznidazole. Nanomedicines reduce toxicity and increase the effectiveness of current oncological therapies. Could nanomedicines improve the treatment of the neglected CD? This question will be addressed in this review, first by critically discussing selected reports on the performance of benznidazole and other molecules formulated as nanomedicines in in vitro and in vivo CD models. Taking into consideration the developmental barriers for nanomedicines and the degree of current technical preclinical efforts, a prospect of developing nanomedicines against CD will be provided. Not surprisingly, we conclude that structurally simpler formulations with minimal production cost, such as oral nanocrystals and/or parenteral nano-immunostimulants, have the highest chances of making it to the market to treat CD. Nonetheless, substantive political and economic decisions, key to facing technological challenges, are still required regarding a realistic use of nanomedicines effective against CD.
Selectfluor and Alcohol Mediated Synthesis of Bicyclic Oxyfluorination Compounds by Wagner-Meerwein Rearrangement
Authors: Dağalan Ziya , Çelikoğlu Muhammed Hanifi , Çelik Saffet , Koçak Ramazan , Nişancı Bilal
Published: March 2024

Herein, we report the first environmentally friendly systematic fluoroalkoxylation reactions in bicyclic systems. New oxyfluorination products were obtained with excellent yields (up to 99%) via Wagner-Meerwein rearrangement using benzonorbornadiene and chiral natural compound (4)-camphene as bicyclic alkenes, selectfluor as an electrophilic fluorine source, and water and various alcohols as nucleophile sources. The structure of bicyclic oxy- and alkoxyfluorine compounds was determined by NMR and GC-MS analyses.
Implementation of Police Chief’s Telegram Mail Number ST/2264/X/HUM.3.4.5/2022 About Law Enforcement for Violation of The Traffic Law an Empirical Study at The Traffic Control Center of State Police of DIY
Authors: Wasiati Cunduk , Muhamad Ibnu Aldira Razak
Published: March 2024

Penerbitan surat edaran Kapolri Nomor :ST/2264/X/HUM.3.4.5/2022 Tanggal 18 Oktober 2022  berpengaruh pada penegakan hukum lalu lintas melalui ETLE. Hal ini dikarenakan surat edaran Kapolri tidak memperbolehkan anggota polri melakukan tilang manual kepada pelanggar padahal yang ditilang melalui ETLE hanya ada 4 jenis pelanggaran. Pelanggaran yang lain tidak boleh dilakukan tilang manual.

Penelitian ini tergolong jenis penelitian deskriptif yang memiliki ciri khas data berbentuk kata-kata dan gambar. Penelitian deskriptif merupakan penelitian yang diarahkan untuk menggambarkan gejala-gejala, fakta-fakta, atau kejadian secara istimewa dan akurat mengenai sifat-sifat populasi maupun daerah tertentu. Adapun metode yang digunakan dalam penelitian ini adalah metode penelitian kualitatif. Implentasi Surat Telegram Kapolri Nomor :ST/2264/X/HUM.3.4.5/2022 Tanggal 18 Oktober 2022 terhadap penegakan hukum pelanggaran lalu lintas. Di Ditlantas Polda DIY jika diterapkan dalam rangka melakukan penegakan hukum bagi pelanggar lalu lintas , masih sulit diterapkan. Hal ini dikarenakan Sanksi E-Tilang hanya bisa diterapkan terhadap 10 (sepuluh) jenis pelanggaran lalu lintas, padahal ada jenis pelanggaran yang tidak termasuk dalam jenis itu yaitu kewajiban memiliki dan membawa surat kelengkapan berkendara berupa SIM dan STNK yang tidak bisa terdeteksi ETLE. Upaya menertibkan pengendara yang belum memiliki SIM tidak bisa dilakukan. Begitu juga upaya menekan angka kriminalitas berupa pencurian kendaraan bermotor karena tidak adanya STNK juga sulit dilakukan.

Faktor penghambat implementasi Surat Telegram Kapolri Nomor :ST/2264/X/HUM.3.4.5/2022 Tanggal 18 Oktober 2022 terhadap penegakan hukum pelanggaran lalu lintas di Ditlantas Polda DIY adalah : Faktor budaya dan masyarakat., Faktor sarana dan fasilitas, Faktor apparat penegak hukum, Faktor hukum.
Legal Consequences For Companies For Violations Of Collective Bargaining Agreements
Authors: Rahmawati Andiani Putri , Mahanani Anajang Esri Edhi
Published: March 2024

ABSTRACT

Collective Labor Agreements (PKB) made between companies and workers' unions must refer to the Law governing Manpower in Indonesia in order to guarantee workers' basic rights, guarantee equality and opportunity and treatment without discrimination for the welfare of workers. If the Collective Labor Agreement made is contrary to applicable laws, it can result in the Collective Labor Agreement being null and void by law. In this research, the writer wants to examine the Juridical Review of the Collective Labor Agreement between PT x and the Workers' Union y. The type of legal research in this thesis is normative legal research and uses qualitative data analysis methods. In the application of the Collective Labor Agreement (PKB) by PT x with the Labor Union y, there are several discrepancies between the contents of the clauses contained in the Collective Labor Agreement (PKB) and the provisions contained in the Law governing Manpower in Indonesia. Even though there are some discrepancies in the contents of the Collective Labor Agreement clause made between PT x and y. However, the substance and other components contained in the Collective Labor Agreement (PKB) are in accordance with the laws governing employment in Indonesia.

Keywords: Collective Labor Agreement, workers, null and void
Legal Protection for Users of The Alodokter Application in Autodebet Cases Without User Consent
Authors: Fauzi Purnama Fahreza , Sutrisno
Published: March 2024

This study aims to identify legal protection as well as legal remedies for consumers who use the Alodokter application for autodebit based on Law no. 8 of 1999 concerning Consumer Protection. The research method is normative, with a statutory approach.The results of the study show that legal protection for users of the Alodokter application is the obligation for business actors toprovide compensation for damage to goods that harm consumers, which can be in the form of refunds or replacement of goods with the same or equivalent value, or health care, and/or compensation. Compensation is made within 7 (seven) days after the transaction date. Legal remedies that can be taken by consumers whose accounts are affectedauto debtwithout approval, namely by peacefully resolving disputes through the process of canceling Alodokter users, resolving disputes through institutions or consumer dispute resolution, up to court.
VALIDITAS BUTIR KUESIONER PERILAKU SISWA BERBASISKAN AJARAN KARMAPATHA SECARA UNIDIMENSI DAN MULTIDIMENSI SEBELUM DIKOREKSI OLEH EFEK SPURIOUS OVERLAP
Authors: Puger I Gusti Ngurah , Dewi Kadek Yati Fitria
Published: March 2024

Tujuan dari penelitian ini adalah untuk mengetahui kelayakan kuesioner perilaku siswa berbasiskan ajaran karmapatha yang digunakan dalam penelitian ini dapat digunakan sebagai instrumen penelitian, jika dikaji dari validitas butirnya secara unidimensi dan multidimensi sebelum dilakukan koreksi oleh efek spurious overlap. Penelitian ini termasuk jenis penelitian kalibrasi instrumen. Populasi penelitian ini adalah seluruh siswa kelas VIII SMP Negeri 2 Seririt, sedangkan sampelnya berupa respon 100 siswa kelas VIII SMP Negeri 2 Seririt setelah diberikan kuesioner perilaku siswa berbasiskan ajaran karmapatha yang dipilih secara purposive sampling. Kuesioner perilaku siswa berbasiskan ajaran karmapatha yang disebarkan pada siswa sudah memiliki kelayakan untuk digunakan lebih lanjut, dikaji dari koefisien content validity (VI), dan koefisien reliabilitas (rxx’) respon antar-rater-nya. Untuk menguji validitas butir kuesioner perilaku siswa berbasiskan ajaran karmapatha secara unidimensi dan multidimensi sebelum dilakukan koreksi oleh efek spurious overlap digunakan formula korelasi product moment. Dari hasil analisis data diperoleh temuan sebagai berikut. (1) Pada pengujian validitas butir kuesioner perilaku siswa berbasiskan ajaran karmapatha secara unidimensi sebelum dilakukan koreksi oleh efek spurious overlap dengan formula korelasi product moment, terdapat 48 butir yang layak digunakan sebagai penyusun kuesioner (yakni butir nomor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, dan 50), dan butir kuesioner yang termasuk kategori drop, yaitu butir tes nomor: 27, dan 42; dan (2) pada pengujian validitas butir kuesioner perilaku siswa berbasiskan ajaran karmapatha secara multidimesi sebelum dikoreksi oleh efek spurious overlap, terdapat 49 butir yang layak digunakan sebagai penyusun kuesioner (yakni butir nomor: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 43, 44, 45, 46, 47, 48, 49, dan 50), dan terdapat 1 butir kuesioner yang berkategori drop, yakni butir nomor: 42. Berdasarkan atas temuan dalam penelitian ini, dapat disimpulkan bahwa: (1) pada pengujian validitas butir kuesioner perilaku siswa berbasiskan ajaran karmapatha secara unidimensi sebelum dikoreksi oleh efek spurious overlap dengan formula korelasi product moment, terdapat 48 butir yang layak digunakan sebagai penyusun kuesioner; dan (2) pada pengujian validitas butir kuesioner perilaku siswa berbasiskan ajaran karmapatha secara multidimesi sebelum dikoreksi oleh efek spurious overlap dengan formula korelasi product moment, terdapat 49 butir yang layak digunakan sebagai penyusun kuesioner.