bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between Willingness and Psychological Characteristics of Suicide Prevention Telephone Counselors: A Retrospective Observational Study
Authors: Murakami Osamu , Kanda Kanae , Ngatu Nlandu Roger , Hirao Tomohiro
Published: September 2021

Suicide is a major public health issue worldwide, and telephone counseling is an important preventive measure. As the number of telephone counselors is insufficient in Japan, public needs cannot be fully met. Willingness is important for securing telephone counselors, but few studies have examined the willingness to engage in telephone counseling activities. Therefore, we investigated the relationship between telephone counselors’ willingness to perform their activities and their psychological characteristics, health status, and received social support. In this study, a questionnaire survey was conducted by mail among telephone counselors belonging to the Federation of Inochi No Denwa in Japan. The total number of valid responses was 709 (recovery rate: 50.4%). Following an exploratory factor analysis, three factors were extracted: (1) willingness to engage in telephone counseling activities, (2) sense of being burdened by telephone counseling activities, and (3) sense of difficulty in coping. Structural equation modeling, using all the factors, showed that social support and grit were directly related to the willingness to engage in telephone counseling activities, while physical health, mental health, and general self-efficacy were indirectly related to it. The findings obtained may be useful in devising concrete measures for telephone counselors to continue their activities.
Mental Resilience of Medical Practitioners in Singapore during COVID-19: Survey Results from a Webinar Course on Resilience
Authors: Low Cheng Hong Charity , Goh Tze Jui , Chan Yiong Huak , Fung Daniel Shuen Sheng , Cheong Pak Yean
Published: September 2021

Front-line doctors are at high risk of exposure to COVID-19. The mental resilience of general practitioners and their areas of concerns and support required are important during this COVID-19 period. A total of 403 general practitioners attending a webinar on resiliency, hosted by the College of Family Physicians, Singapore, participated in the survey anonymously. Participants provided responses to questions relating to COVID-19 in the domains of Family and friends, Myself, Practice, and Community. Responses are categorized into LEARNING, FEAR, and GROWTH zones. The majority of the doctors reported to be in the GROWTH zone in relation to Family and friends (39%) and Myself (38%) as compared to Practice and Community, aOR = 4.5 (95% CI 3.4 to 5.9), p < 0.001. 34% of the participants reported being in the FEAR zone in relation to Family and friends, aOR = 8.0 (95% CI = 5.6 to 11.2), p < 0.001; at least 81% reported being in the LEARNING zone in relation to Practice and Community, aOR = 7.5 (95% CI = 5.8 to 9.6), p < 0.001, compared to other domains. Supporting and protecting the doctors is important in strategic planning and management of the current pandemic and building preparedness and an effective response towards future crises.
Why Does the SARS-CoV-2 Delta VOC Spread So Rapidly? Universal Conditions for the Rapid Spread of Respiratory Viruses, Minimum Viral Loads for Viral Aerosol Generation, Effects of Vaccination on Viral Aerosol Generation, and Viral Aerosol Clouds
Authors: Lee Byung Uk
Published: September 2021

This study analyzes the reasons the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Delta variant of concern (VOC) spreads so rapidly. Novel topics such as universal conditions for the rapid spread of respiratory viruses, minimum viral loads for viral aerosol generation, effects of vaccination on viral aerosol generation, and viral aerosol clouds were studied. The analyses were based on experimental results and analytic model studies. Four universal conditions, namely asymptomatic host, high viral load, stability of viruses in air, and binding affinity of viruses to human cells, need to be satisfied for the rapid spread of respiratory viruses. SARS-CoV-2 and its variants such as the Alpha VOC and Delta VOC satisfy the four fundamental conditions. In addition, there is an original principle of aerosol generation of respiratory viruses. Assuming that the aerosol–droplet cutoff particle diameter for distinguishing potential aerosols from earthbound respiratory particles is 100 μm, the minimum viral load required in respiratory fluids to generate viral aerosols is ~106 copies mL−1, which is within the range of the reported viral loads in the Alpha VOC cases and the Delta VOC cases. The daily average viral loads of the Delta VOC in hosts have been reported to be between ~109 copies mL−1 and ~1010 copies mL−1 during the four days after symptom onset in 1848 cases of the Delta VOC infection. Owing to the high viral load, the SARS-CoV-2 Delta VOC has the potential to effectively spread through aerosols. COVID-19 vaccination can decrease aerosol transmission of the SARS-CoV-2 Alpha VOC by reducing the viral load. The viral load can explain the conundrum of viral aerosol spreading. The SARS-CoV-2 Delta VOC aerosol clouds have been assumed to be formed in restricted environments, resulting in a massive numbers of infected people in a very short period with a high spreading speed. Strong control methods against bioaerosols should be considered in this SARS-CoV-2 Delta VOC pandemic. Large-scale environmental monitoring campaigns of SARS-CoV-2 Delta VOC aerosols in public places in many countries are necessary, and these activities could contribute to controlling the coronavirus disease pandemic.
Improving Healthy Aging by Monitoring Patients’ Lifestyle through a Wearable Device: Results of a Feasibility Study
Authors: Fioranzato Maria , Comoretto Rosanna Irene , Lanera Corrado , Pressato Lamberto , Palmisano Giuseppe , Barbacane Luca , Gregori Dario
Published: September 2021

Population aging is related to a huge growth in healthcare and welfare costs. Therefore, wearable devices could be strategic for minimizing years of disability in old age and monitoring patients’ lifestyles and health. The purpose of this study was to assess the feasibility of using smart devices to monitor patients’ physical activity in a primary care setting. To assess the acceptance of this novel technology from the point of view of both patients and healthcare professionals, two questionnaires (one paper-based and one ex-novo developed) were administered to 11 patients with type 2 diabetes mellitus and a non-compliant behavior towards the therapeutic indications of their general practitioner (GP). Seven participants would continue to use a wearable activity tracker to monitor their health. We observed that 75% of patients reported a device’s characteristics satisfaction level of over 80% of the total score assigned to this dimension. No differences were observed in the questionnaire’s scores between the two professionals categories (GPs and nurses). Three dimensions (equipment characteristics, subjective norm, perceived risks, perceived ease-of-use and facilitating conditions) correlated > 0.5 with the device’s acceptability level. Some weak correlations were observed between healthcare professionals’ perception and patients’ parameters, particularly between the dimensions of collaboration and web interface ease-of-use and patients’ median number of steps and hours of sleep. In conclusion, despite the limited number of subjects involved, a good acceptance level towards these non-medical devices was observed, according to both patients’ and healthcare professionals’ impressions.
Do Gender and Gender Role Orientation Make a Difference in the Link between Role Demands and Family Interference with Work for Taiwanese Workers?
Authors: Lu Luo , Chang Ting-Ting , Kao Shu-Fang , Cooper Cary L.
Published: September 2021

Based on the gender role orientation perspective, this study extends the resource depletion mechanism that links role demands to family interference with work by testing the moderating effects of gender and gender role orientation (egalitarian vs. traditional) on the relationships. Analysis of the data from 251 employees in Taiwan revealed two significant three-way interactive effects. Specifically, for men, the positive relationship between work demands and family-to-work conflict (FWC) was stronger for egalitarian than traditional individuals. For women, the positive relationship between family demands and FWC was stronger for egalitarian than traditional individuals. We also found a significant two-way interactive effect; that is, within the egalitarian group, the positive relationship between work demands and FWC was stronger for women than men. Our findings, thus, suggest both within-gender and between-gender variations in the links between work-to-family demands and conflict, jointly affected by the individual’s gender and gender role orientation. Contextualized within the cultural traditions of a Chinese society, we highlight the precarious position that egalitarian men and women (especially women) find for themselves in fulfilling work duties and family roles. The theoretical and managerial implications are also discussed.
Analysis of EEG Characteristics of Drivers and Driving Safety in Undersea Tunnel
Authors: Yang Yongzheng , Du Zhigang , Jiao Fangtong , Pan Fuquan
Published: September 2021

To study the influence of the driving environment of an undersea tunnel on driver EEG (electroencephalography) characteristics and driving safety, a real vehicle experiment was performed in the Qingdao Jiaozhou Bay Tunnel. The experimental data of the drivers’ real vehicle experiment were collected using an illuminance meter, EEG instrument, video recorder and other experimental equipment. The undersea tunnel is divided into different areas, and the distribution law of driving environment characteristics, EEG characteristics and vehicle speed characteristics is analyzed. The correlations between the driving environment characteristics, EEG characteristics and vehicle speed characteristics model the variables that pass the correlation test. The driving safety evaluation model of an undersea tunnel is established, and the driving safety in different areas of the undersea tunnel is evaluated. The results show that there are obvious differences in illumination, EEG power change rate, vehicle speed and other variables in different areas of the undersea tunnel. The driving environment characteristics are highly correlated with the β wave power change rate. The driving safety of different areas of the undersea tunnel from high to low is: upslope area, downslope area, exit area and entrance area. The study will provide a theoretical basis for the safe operation of the undersea tunnel.
Using Low-Cost Sensors to Assess Fine Particulate Matter Infiltration (PM2.5) during a Wildfire Smoke Episode at a Large Inpatient Healthcare Facility
Authors: Nguyen Phuong D. M. , Martinussen Nika , Mallach Gary , Ebrahimi Ghazal , Jones Kori , Zimmerman Naomi , Henderson Sarah B.
Published: September 2021

Wildfire smoke exposure is associated with a range of acute health outcomes, which can be more severe in individuals with underlying health conditions. Currently, there is limited information on the susceptibility of healthcare facilities to smoke infiltration. As part of a larger study to address this gap, a rehabilitation facility in Vancouver, Canada was outfitted with one outdoor and seven indoor low-cost fine particulate matter (PM2.5) sensors in Air Quality Eggs (EGG) during the summer of 2020. Raw measurements were calibrated using temperature, relative humidity, and dew point derived from the EGG data. The infiltration coefficient was quantified using a distributed lag model. Indoor concentrations during the smoke episode were elevated throughout the building, though non-uniformly. After censoring indoor-only peaks, the average infiltration coefficient (range) during typical days was 0.32 (0.22–0.39), compared with 0.37 (0.31–0.47) during the smoke episode, a 19% increase on average. Indoor PM2.5 concentrations quickly reflected outdoor conditions during and after the smoke episode. It is unclear whether these results will be generalizable to other years due to COVID-related changes to building operations, but some of the safety protocols may offer valuable lessons for future wildfire seasons. For example, points of building entry and exit were reduced from eight to two during the pandemic, which likely helped to protect the building from wildfire smoke infiltration. Overall, these results demonstrate the utility of indoor low-cost sensors in understanding the impacts of extreme smoke events on facilities where highly susceptible individuals are present. Furthermore, they highlight the need to employ interventions that enhance indoor air quality in such facilities during smoke events.
Removal of Arsenic Oxyanions from Water by Ferric Chloride—Optimization of Process Conditions and Implications for Improving Coagulation Performance
Authors: Inam Muhammad Ali , Khan Rizwan , Lee Kang-Hoon , Wie Young-Min
Published: September 2021

The chronic ingestion of arsenic (As) contaminated water has raised significant health concerns worldwide. Iron-based coagulants have been widely used to remove As oxyanions from drinking water sources. In addition, the system’s ability to lower As within the maximum acceptable contamination level (MCL) is critical for protecting human health from its detrimental effects. Accordingly, the current study comprehensively investigates the performance of As removal under various influencing factors including pH, contact time, temperature, As (III, V) concentration, ferric chloride (FC) dose, and interfering ions. The optimum pH for As (V) removal with FC was found to be pH 6–7, and it gradually decreased as the pH increased. In contrast, As (III) removal increased with an increase in pH with an optimum pH range of 7–10. The adsorption of As on precipitated iron hydroxide (FHO) was better fitted with pseudo-second order and modified Langmuir–Freundlich models. The antagonistic effect of temperature on As removal with FC was observed, with optimum temperature of 15–25 °C. After critically evaluating the optimum operating conditions, the uptake indices of both As species were developed to select appropriate an FC dose for achieving the MCL level. The results show that the relationship between residual concentration, FC dose, and adsorption affinity of the system was well represented by uptake indices. The higher FC dose was required for suspensions containing greater concentration of As species to achieve MCL level. The As (V) species with a greater adsorption affinity towards FHO require a relatively smaller FC dose than As (III) ions. Moreover, the significant influence of interfering species on As removal was observed in simulated natural water. The author hopes that this study may help researchers and the drinking water industry to develop uptake indices of other targeted pollutants in achieving MCL level during water treatment operations in order to ensure public health safety.
The Cotton Dust-Related Allergic Asthma: Prevalence and Associated Factors among Textile Workers in Nam Dinh Province, Vietnam
Authors: Ha Tran Thi Thuy , Hanh Bui My , Van Son Nguyen , Giang Hoang Thị , Hai Nguyen Thanh , Thuc Vu Minh , Khue Pham Minh
Published: September 2021

Objective: To determine the prevalence of cotton dust-related allergic asthma and associated factors among textile workers in Nam Dinh province, Vietnam. Methods: A cross-sectional study was performed with 1082 workers in two textile garment companies using the asthma diagnostic criteria of the GINA (Global Initiative for Asthma) 2016 guidelines. Results: Among study participants, 11.9% had suspected asthma symptoms, 7.4% were diagnosed with asthma, and 4.3% (3.6% in men and 4.5% in women) were diagnosed with cotton dust-related allergic asthma. Overweight, seniority more than 10 years, history of asthma, allergic rhinitis, family history of allergy, and exposure to cotton dust from more than one hour per day in the working environment were found to be important predictors of cotton dust-related allergic asthma among textile workers. Conclusions: Textile workers in two companies in Nam Dinh, Vietnam had a high prevalence of dust-related allergic asthma compared to estimates from the general population. There is a need to design appropriate measures of prevention, screening, and care for dust-related asthma in the textile industry. Further evaluation with better exposure assessment is necessary.
Can Political Trust Weaken the Relationship between Perceived Environmental Threats and Perceived Nuclear Threats? Evidence from South Korea
Authors: Lim Jaeyoung , Moon Kuk-Kyoung
Published: September 2021

As environmental movements rage, how to handle nuclear power plants has become a hotly contested issue globally. While concerns about nuclear power plants are warranted, nuclear power plants may play a crucial role in climate change discourse. In this context, this study examines the connections between individuals’ perceived environmental threats and their perceptions of the environmental threats posed by nuclear power plants (perceived nuclear threats). In particular, the study explores whether such connections are moderated by individuals’ level of political trust, such that political trust helps weaken perceptions of threats individuals may feel from nuclear power plants. Using the 2014 Korean General Social Survey and ordered probit, this study confirmed that individuals’ perceived environmental threats were positively associated with their perceived nuclear threats. Additionally, individuals with a high level of trust in the government can help alleviate the positive link between individuals’ perceived environmental threats and perceived nuclear threats.
Older Women’s Experiences of a Community-Led Walking Programme Using Activity Trackers
Authors: O’Brien Jessica , Mason Amy , Cassarino Marica , Chan Jason , Setti Annalisa
Published: September 2021

Promoting physical activity amongst older adults represents a major public health goal and community-led exercise programmes present benefits in promoting active lifestyles. Commercial activity trackers potentially encourage positive behaviour change with respect to physical exercise. This qualitative study investigated the experiences and attitudes of older adults following a 6-week community-led walking programme utilising activity trackers. Eleven community-dwelling older women aged 60+ completed individual phone interviews following their involvement in the programme. The programme, codesigned with a group of senior citizens, equipped participants with wrist-worn activity trackers and included biweekly check-in sessions with a researcher to monitor progress and support motivation. Interviews explored participants’ experiences of the programme and of using activity trackers for the purpose of becoming more active. A thematic analysis produced three main themes: ‘programme as a source of motivation’, ‘user experiences with the technology’ and ‘views on social dimension of the programme’. Overall, participants highlighted the self-monitoring function of activity trackers as most beneficial for their exercise levels. This study provides insights into the personal and social factors perceived by older adults in relation to being part of a community-led programme using activity trackers. It highlights the role of the programme and trackers in maintaining motivation to stay active.
Job Demands and Exhaustion in Firefighters: The Moderating Role of Work Meaning. A Cross-Sectional Study
Authors: Roșca Andra Cătălina , Mateizer Alexandru , Dan Cristina-Ioana , Demerouti Evangelia
Published: September 2021

Emotional exhaustion and other symptoms of burnout are often found among emergency services professions, such as firefighting. Given the social importance of this activity and the high responsibility it requires, prevention and alleviation of burnout symptoms become primary concerns in ensuring the well-being of firefighters. Although work meaning is one of the factors associated with a lower risk of developing burnout, its protective role has not been studied in firefighters. Therefore, the purpose of this study was to assess the buffering role of work meaning in the health-impairment process of the Job Demands-Resources model, targeting the relationship between job demands and related emotional exhaustion. A cross-sectional survey design was used to collect data from a sample consisting of Romanian firefighters (n = 1096). Structural equation modeling indicated a positive link between job demands and exhaustion. In addition, deriving personal meaning from work was associated with lower levels of exhaustion in firefighters. A small but significant interaction effect between work meaning and job demands showed that higher levels of work meaning attenuated the positive relationship between job demands and exhaustion. In conclusion, our findings suggest that work meaning has a buffering effect on the impact of various job demands on job-related exhaustion. Nevertheless, the small effect sizes warrant further research on this topic.
Characteristics of Home-Visit Nursing Agencies That Closed after the 2012 Fee Revision for Home-Visit Nursing Services: A Nationwide Panel Data Analysis in Japan
Authors: Kashiwagi Masayo , Morioka Noriko
Published: September 2021

Despite the 2012 fee revision raising fees for home-visit nursing services to increase their supply in Japan, 300 to 500 home-visit nursing agencies (VNA) are still being closed annually. This study aims to identify the regional and organizational characteristics of the VNAs that closed after the 2012 fee revision. A longitudinal observational study was conducted using nationwide panel data of VNAs from 2014 to 2017 (N = 6496). Multiple logistic regression models stratified by years of operation were used for the analysis. We identified 821 closed agencies (12.6%). In this study, many important factors related to VNA closures were found. In the less than three years group, there were regional factors (lower aging rate and larger number of clinics) and an organizational factor (higher proportion of users under 40 years of age). In the 3–14 years group, there was a regional factor (larger number of clinics) and organizational factors (smaller number of FTE nurses, smaller number of users per FTE nurse, and smaller number of medical care types that can be provided). In the over 15 years group, there was an organizational factor (smaller number of FTE nurses). The findings provide valuable insights for policymakers in avoiding VNA closures.
Drinking and Night-Time Driving May Increase the Risk of Severe Health Outcomes: A 5-Year Retrospective Study of Traffic Injuries among International Travelers at a University Hospital Emergency Center in Thailand
Authors: Sapsirisavat Vorapot , Mahikul Wiriya
Published: September 2021

Road traffic injury (RTI) is a leading cause of death in developing countries. This burden affects not only locals, but also international travelers. Data on international travelers with RTIs in Thailand, especially from a medical perspective, are limited. This study aimed to analyze the factors associated with severe health outcomes following RTIs among international travelers at a university hospital emergency center in Thailand from January 2015 to December 2019. The retrieved data consisted of demographics, risks, preventive factors, and health outcomes. The severity of outcome was classified as fatality, hospitalization, or non-severe. A multinomial logistic regression model was used to identify the possible determinants of severity of health outcome among international travelers with RTI. A total of 720 travelers with RTIs (69% males; 82.5% were Southeast Asian) were included, with a mean age of 28.5 years. Of these, 144 (20%) had severe health outcomes: 64 (9%) fatalities and 80 (11%) hospitalizations. The level of severity of outcome was not associated with travelers’ demographics, but was associated with conventional risk factors, i.e., motorcycle use, alcohol/drug use, night-time driving, and less use of seatbelt/helmet. In a multinomial logistic regression analysis, alcohol drinking (adjusted odds ratio (AOR) 2.53, 95% confidence interval (CI) 1.41–4.55) and night-time driving (AOR 2.54, 95% CI 1.36–4.75) were associated with hospitalization. Patients who had a history of tetanus vaccination were less likely to die (AOR 0.37, 95% CI 0.17–0.81). In conclusion, one-fifth of RTIs resulted in severe health outcomes, and 9% were fatal. Road safety campaigns in Thailand should target travelers of all nationalities. Interventions that enhance travelers’ safety practices and proper preparation for road accidents should be explored further.
Developing a Conceptual Model for the Post-COVID-19 Pandemic Changing Tourism Risk Perception
Authors: Chan Chung-Shing
Published: September 2021

The global coronavirus (COVID-19) pandemic has tremendously reshaped the tourism industry and destinations worldwide. Tourism destinations and the travel market require empirical research to support their post-pandemic strategies, especially in relation to the influences of changing perceptions of tourism risks, experience, and behavioural intention. This paper aims to propose a conceptual model and its hypotheses of the perceived tourism risks of natural and man-made disasters to explain the associations between the expected travel experience and ultimate travel behaviour. This paper provides a foundation for further empirical study based on a literature review and discussion. Several areas of theoretical development are identified for immediate research: (1) comparison of self-interpretation and understanding of multi-dimensional tourism risks of natural and man-made complexity in epidemics across a great variety of geographical and geo-political territories; (2) a complex web of influence to changing safety concerns and risk perception by information dissemination; (3) the effect of destination selection or hesitation in travel intention caused by changing destination image; and (4) local perception of the epidemic and health crisis. Destination authorities are recommended to (1) strengthen the preparedness and emergency responses of an effective disaster management process, (2) maintain the emotional solidarity of both tourists and local residents, and (3) mitigate multiple dimensions of the perceived risks, mainly associated with the health and psychological risks of those affected.
Quantifying Coordination between Agonist and Antagonist Elbow Muscles during Backhand Crosscourt Shots in Adult Female Squash Players
Authors: Akl Abdel-Rahman , Hassan Amr , Elgizawy Helal , Tilp Markus
Published: September 2021

The purpose of this study was to quantify the coordination between agonist and antagonist elbow muscles during squash backhand crosscourt shots in adult female players. Ten right-handed, international-level, female squash players participated in the study. The electrical muscle activity of two right elbow agonist/antagonist muscles, the biceps brachii and triceps brachii, were recorded using a surface EMG system, and processed using the integrated EMG to calculate a co-activation index (CoI) for the preparation phase, the execution phase, and the follow-through phase. A significant effect of the phases on the CoI was observed. Co-activation was significantly different between the follow-through and the execution phase (45.93 ± 6.00% and 30.14 ± 4.11%, p < 0.001), and also between the preparation and the execution phase (44.74 ± 9.88% and 30.14 ± 4.11%, p < 0.01). No significant difference was found between the preparation and the follow-through phase (p = 0.953). In conclusion, the co-activation of the elbow muscles varies within the squash backhand crosscourt shots. The highest level of co-activation was observed in the preparation phase and the lowest level of co-activation was observed during the execution. The co-activation index could be a useful method for the interpretation of elbow muscle co-activity during a squash backhand crosscourt shot.
Metabolic Syndrome and Its Related Factors among Hospital Employees: A Population-Based Cohort Study
Authors: Wu Yi-Syuan , Tzeng Wen-Chii , Chu Chi-Ming , Wang Wei-Yun
Published: September 2021

Several studies have reported on metabolic syndrome (MetS) based on cross-sectional designs, which cannot show a long-term result. Information is lacking on MetS and related factors based on a longitudinal cohort. This study aimed to examine the relationship between MetS and related factors for a total of six years among hospital employees. A population-based study was conducted, including 746 staff. A total of 680 staff without MetS in 2012 were enrolled in the analysis for repeated measurement of six years of the longitudinal cohort. Data were retrieved from the hospital’s Health Management Information System. Analyses were performed using Student’s t-test, chi-square test, logistic regression, and generalised estimating equations. Statistical significance was defined as p < 0.05. Hospital employees aged between 31 and 40 (odds ratio (OR) = 4.596, p = 0.009), aged between 41 and 50 (OR = 7.866, p = 0.001), aged greater than 50 (OR = 10.312, p < 0.001), with a body mass index (BMI) of 25.0~29.9 kg/m2 (OR = 3.934, p < 0.001), a BMI ≥ 30 kg/m2 (OR = 13.197, p < 0.001), higher level of white blood counts (β = 0.177, p = 0.001), alanine aminotransferase (β = 0.013, p = 0.002), and uric acid (β = 0.223, p = 0.005) were at risk of being diagnosed with MetS. The identification of at-risk hospital employees and disease management programs addressing MetS-related factors are of great importance in hospital-based interventions.
Characterisation of Bacterial Isolates from Infected Post-Operative Patients in a Malaysian Tertiary Heart Care Centre
Authors: Yong Yi Keng , Wen Nicole Ce Mun , Yeo Genieve Ee Chia , Chew Zhi Xin , Chan Li Li , Md Zain Noor Zaitulakma , Chellappan Dinesh Kumar , Liew Yun Khoon
Published: September 2021

Several bacterial species cause post-operative infections, which has been a critical health concern among hospital patients. Our study in this direction is a much-needed exploratory study that was carried out at the National Heart Institute (IJN) of Malaysia to examine the virulence properties of causative bacteria obtained from postoperative patients. The bacterial isolates and data were provided by the IJN. Antibiotic resistance gene patterns, and the ability to form biofilm were investigated for 127 isolates. Klebsiella pneumoniae (36.2%) was the most common isolate collected, which was followed by Pseudomonas aeruginosa (26%), Staphylococcus aureus (23.6%), Streptococcus spp. (8.7%) and Acinetobacter baumannii (5.5%). There were 49 isolates that showed the presence of multidrug resistance genes. The mecA gene was surprisingly found in methicillin-susceptible S. aureus (MSSA), which also carried the ermA gene from those erythromycin-susceptible strains. The phenotypic antibiotic resistance profiles varied greatly between isolates. Findings from the biofilm assay revealed that 44 of the 127 isolates demonstrated the ability to produce biofilms. Our findings provide insights into the possibility of some of these bacteria surviving under antibiotic stress, and some antibiotic resistance genes being silenced.
Increased Work Experience Associated with Less Stigmatizing Attitudes towards People Living with HIV among Thai Healthcare Personnel
Authors: Srithanaviboonchai Kriengkrai , Khemngern Porntip , Chuayen Jarun , Siraprapasiri Taweesap
Published: September 2021

HIV-related stigma in health facilities has been suggested as a primary target for HIV-related stigma reduction. The objective of this study was to describe negative attitudes among Thai healthcare personnel (HCP) toward PLHIV. This nationwide probability sampled survey was conducted in 2019 in 12 provinces in Thailand and Bangkok, the capital. Participants were considered to have stigmatizing attitudes toward PLHIV if they had a stigmatizing view in response to at least one of the four questions. Eighty-two percent of the 3056 respondents had at least one stigmatizing attitude. Younger HCP, ages < 30 (AOR = 1.60; 95%CI: 1.18–2.18) and 30–39 (AOR = 1.60; 95%CI: 1.21–2.12) were more likely to have stigmatizing attitudes towards PLHIV compared to those aged 50 and older. Being support staff, support-clinical (AOR = 1.89; 95%CI: 1.44–2.49) and support-nonclinical (AOR = 1.71; 95%CI: 1.24–2.36) as opposed to professional staff also increased the likelihood of having stigmatizing attitudes. Stigma was also more likely to be present in HCPs who did not work at HIV-focused clinics (AOR = 1.97; 95%CI: 1.57–2.48). HCP who had more work experience, especially related to PLHIV care, were less likely to have stigmatizing attitudes. These personnel could be good peer educators or role models for a stigma reduction campaign within their healthcare facilities.
Land-Use Suitability Assessment Using Delphi and Analytical Hierarchy Process (D-AHP) Hybrid Model for Coastal City Management: Kuala Terengganu, Peninsular Malaysia
Authors: Bagheri Milad , Zaiton Ibrahim Zelina , Mansor Shattri , Manaf Latifah Abd , Akhir Mohd Fadzil , Talaat Wan Izatul Asma Wan , Beiranvand Pour Amin
Published: September 2021

Since at least half of the world’s population resides and works within coastal land, the coastal zone processes and resource management is of great economic and social importance. One of the fundamental issues for coastal city planners, researchers, managers, and engineers is the coastal city land-use suitability. Land-use suitability is the ability of a given type of land to support a defined use. Rapid urbanization and consequent haphazard growth of cities result in deterioration of infrastructure facilities, loss of agricultural land, water bodies, open spaces, and many micro-climatic changes. Hence, accurate data on coastal city hazards are essential and valuable tools for coastal planning and management, sustainable coastal development, coastal environment conservation, selection of a site for coastal city structures, and coastal resources. In this investigation, the Delphi and Analytical Hierarchy Process (D-AHP) Hybrid model and Geographic Information System (GIS) technique for Coastal Land-Use Assessment (CLUA) are mapped to detect the most suitable and unsuitable areas in the Kuala Terengganu coastal zone. Furthermore, this research offered information not only on the present urban land-use trend and established amenity status in Kuala Terengganu, but also on the suitability of land for the potential establishment of urban facilities for improved urban planning and appropriate decision-making. Using the D-AHP Hybrid model and GIS tool for coastal city management is broadly practical for government, policymakers, and planners to appropriately strategize and plan for the future of coastal cities in Malaysia and other analog coastal cities around the world.
Exploring the Factors of Intercity Ridesplitting Based on Observed and GIS Data: A Case Study in China
Authors: Wang Jincheng , Wu Qunqi , Chen Zilin , Ren Yilong , Gao Yaqun
Published: September 2021

Ridesplitting, a form of ridesourcing in which riders with similar origins and destinations are matched, is an effective mode of sustainable transportation. In recently years, ridesplitting has spread rapidly worldwide and plays an increasingly important role in intercity travel. However, intercity ridesplitting has rarely been studied. In this paper, we use observe intercity ridesplitting data between Yinchuan and Shizuishan in China and building environment data based on a geographic information system (GIS) to analyse temporal, spatial and other characteristics. Then, we divide the study area into grids and explore the contributing factors that affect the intercity ridesplitting matching success rate. Based on these significant factors, we develop a binary logistic regression (BLR) model and predict the intercity ridesplitting matching success rate. The results indicate that morning peak, evening peak, weekends and weekdays, precipitation and snowfall, population density, some types of points of interest (POI), travel time and the advance appointment time are significant factors. In addition, the prediction accuracy of the model is more than 78%, which shows that the factors studied in this paper have good explanatory power. The results of this study can help in understanding the characteristics of intercity ridesplitting and provide a reference for improving the intercity ridesplitting matching success rate.
High Spatial-Temporal Resolution Estimation of Ground-Based Global Navigation Satellite System Interferometric Reflectometry (GNSS-IR) Soil Moisture Using the Genetic Algorithm Back Propagation (GA-BP) Neural Network
Authors: Shi Yajie , Ren Chao , Yan Zhiheng , Lai Jianmin
Published: September 2021

Soil moisture is one of the critical variables in maintaining the global water cycle balance. Moreover, it plays a vital role in climate change, crop growth, and environmental disaster event monitoring, and it is important to monitor soil moisture continuously. Recently, Global Navigation Satellite System interferometric reflectometry (GNSS-IR) technology has become essential for monitoring soil moisture. However, the sparse distribution of GNSS-IR soil moisture sites has hindered the application of soil moisture products. In this paper, we propose a multi-data fusion soil moisture inversion algorithm based on machine learning. The method uses the Genetic Algorithm Back-Propagation (GA-BP) neural network model, by combining GNSS-IR site data with other surface environmental parameters around the site. In turn, soil moisture is obtained by inversion, and we finally obtain a soil moisture product with a high spatial and temporal resolution of 500 m per day. The multi-surface environmental data include latitude and longitude information, rainfall, air temperature, land cover type, normalized difference vegetation index (NDVI), and four topographic factors (elevation, slope, slope direction, and shading). To maximize the spatial and temporal resolution of the GNSS-IR technique within a machine learning framework, we obtained satisfactory results with a cross-validated R-value of 0.8660 and an ubRMSE of 0.0354. This indicates that the machine learning approach learns the complex nonlinear relationships between soil moisture and the input multi-surface environmental data. The soil moisture products were analyzed compared to the contemporaneous rainfall and National Aeronautics and Space Administration (NASA)’s soil moisture products. The results show that the spatial distribution of the GA-BP inversion soil moisture products is more consistent with rainfall and NASA products, which verifies the feasibility of using this experimental model to generate 500 m per day the GA-BP inversion soil moisture products.
A Temporal Directed Graph Convolution Network for Traffic Forecasting Using Taxi Trajectory Data
Authors: Chen Kaiqi , Deng Min , Shi Yan
Published: September 2021

Traffic forecasting plays a vital role in intelligent transportation systems and is of great significance for traffic management. The main issue of traffic forecasting is how to model spatial and temporal dependence. Current state-of-the-art methods tend to apply deep learning models; these methods are unexplainable and ignore the a priori characteristics of traffic flow. To address these issues, a temporal directed graph convolution network (T-DGCN) is proposed. A directed graph is first constructed to model the movement characteristics of vehicles, and based on this, a directed graph convolution operator is used to capture spatial dependence. For temporal dependence, we couple a keyframe sequence and transformer to learn the tendencies and periodicities of traffic flow. Using a real-world dataset, we confirm the superior performance of the T-DGCN through comparative experiments. Moreover, a detailed discussion is presented to provide the path of reasoning from the data to the model design to the conclusions.
The Role of Gut Microbiota and Gut–Brain Interplay in Selected Diseases of the Central Nervous System
Authors: Doroszkiewicz Julia , Groblewska Magdalena , Mroczko Barbara
Published: September 2021

The gut microbiome has attracted increasing attention from researchers in recent years. The microbiota can have a specific and complex cross-talk with the host, particularly with the central nervous system (CNS), creating the so-called “gut–brain axis”. Communication between the gut, intestinal microbiota, and the brain involves the secretion of various metabolites such as short-chain fatty acids (SCFAs), structural components of bacteria, and signaling molecules. Moreover, an imbalance in the gut microbiota composition modulates the immune system and function of tissue barriers such as the blood–brain barrier (BBB). Therefore, the aim of this literature review is to describe how the gut–brain interplay may contribute to the development of various neurological disorders, combining the fields of gastroenterology and neuroscience. We present recent findings concerning the effect of the altered microbiota on neurodegeneration and neuroinflammation, including Alzheimer’s and Parkinson’s diseases, as well as multiple sclerosis. Moreover, the impact of the pathological shift in the microbiome on selected neuropsychological disorders, i.e., major depressive disorders (MDD) and autism spectrum disorder (ASD), is also discussed. Future research on the effect of balanced gut microbiota composition on the gut–brain axis would help to identify new potential opportunities for therapeutic interventions in the presented diseases.
Synergistic Effect of Simultaneous versus Sequential Combined Treatment of Histone Deacetylase Inhibitor Valproic Acid with Etoposide on Melanoma Cells
Authors: Shyu Yueh-Ming , Liu Lawrence Yu-Min , Chuang Yung-Jen
Published: September 2021

Melanoma is the most lethal form of skin cancer, which is intrinsically resistant to conventional chemotherapy. Combination therapy has been developed to overcome this challenge and show synergistic anticancer effects on melanoma. Notably, the histone deacetylase inhibitor, valproic acid (VPA), has been indicated as a potential sensitizer of chemotherapy drugs on various metastatic cancers, including advanced melanoma. In this study, we explored whether VPA could serve as an effective sensitizer of chemotherapy drug etoposide (ETO) on B16-F10 and SK-MEL-2-Luc melanoma cell lines in response to drug-induced DNA damages. Our results demonstrated that the VPA-ETO simultaneous combined treatment and ETO pretreated sequential combined treatment generated higher inhibitory effectivities than the individual treatment of each drug. We found the VPA-ETO simultaneous combined treatment contributed to the synergistic inhibitory effect by the augmented DNA double-strand breaks, accompanied by a compromised homologous recombination activity. In comparison, the ETO pretreated sequential combined treatment led to synergistic inhibitory effect via enhanced apoptosis. Surprisingly, the enhanced homologous recombination activity and G2/M phase arrest resulted in the antagonistic effect in both cells under VPA pretreated sequential combined treatment. In summary, our findings suggested that sequential order and effective dose of drug administration in VPA-ETO combination therapy could induce different cellular responses in melanoma cells. Such understanding might help potentiate the effectiveness of melanoma treatment and highlight the importance of sequential order and effective dose in combination therapy.
Androgen Receptor Signaling Induces Cisplatin Resistance via Down-Regulating GULP1 Expression in Bladder Cancer
Authors: Teramoto Yuki , Jiang Guiyang , Goto Takuro , Mizushima Taichi , Nagata Yujiro , Netto George J. , Miyamoto Hiroshi
Published: September 2021

The underlying molecular mechanisms of resistance to cisplatin-based systemic chemotherapy in bladder cancer patients remain to be elucidated, while the link between androgen receptor (AR) activity and chemosensitivity in urothelial cancer has been implicated. Our DNA microarray analysis in control vs. AR knockdown bladder cancer lines identified GULP1 as a potential target of AR signaling. We herein determined the relationship between AR activity and GULP1 expression in bladder cancer cells and then assessed the functional role of GULP1 in cisplatin sensitivity. Androgen treatment in AR-positive cells or AR overexpression in AR-negative cells considerably reduced the levels of GULP1 expression. Chromatin immunoprecipitation further showed direct interaction of AR with the promoter region of GULP1. Meanwhile, GULP1 knockdown sublines were significantly more resistant to cisplatin treatment compared with respective controls. GULP1 knockdown also resulted in a significant decrease in apoptosis, as well as a significant increase in G2/M phases, when treated with cisplatin. In addition, GULP1 was immunoreactive in 74% of muscle-invasive bladder cancers from patients who had subsequently undergone neoadjuvant chemotherapy, including 53% of responders showing moderate (2+)/strong (3+) expression vs. 23% of non-responders showing 2+/3+ expression (P = 0.044). These findings indicate that GULP1 represents a key downstream effector of AR signaling in enhancing sensitivity to cisplatin treatment.
The Relationship between the Spatial Arrangement of Pigments and Exciton Transition Moments in Photosynthetic Light-Harvesting Complexes
Authors: Pishchalnikov Roman Y. , Chesalin Denis D. , Razjivin Andrei P.
Published: September 2021

Considering bacteriochlorophyll molecules embedded in the protein matrix of the light-harvesting complexes of purple bacteria (known as LH2 and LH1-RC) as examples of systems of interacting pigment molecules, we investigated the relationship between the spatial arrangement of the pigments and their exciton transition moments. Based on the recently reported crystal structures of LH2 and LH1-RC and the outcomes of previous theoretical studies, as well as adopting the Frenkel exciton Hamiltonian for two-level molecules, we performed visualizations of the LH2 and LH1 exciton transition moments. To make the electron transition moments in the exciton representation invariant with respect to the position of the system in space, a system of pigments must be translated to the center of mass before starting the calculations. As a result, the visualization of the transition moments for LH2 provided the following pattern: two strong transitions were outside of LH2 and the other two were perpendicular and at the center of LH2. The antenna of LH1-RC was characterized as having the same location of the strongest moments in the center of the complex, exactly as in the B850 ring, which actually coincides with the RC. Considering LH2 and LH1 as supermolecules, each of which has excitation energies and corresponding transition moments, we propose that the outer transitions of LH2 can be important for inter-complex energy exchange, while the inner transitions keep the energy in the complex; moreover, in the case of LH1, the inner transitions increased the rate of antenna-to-RC energy transfer.