bluuebunny/crossref_metadata_2025 huggingface dataset:
The use of biological glue (Starsil® Hemostat) in robotic partial nephrectomy: a safety and efficacy study
Authors: Ariel Zisman , Omri Nativ , Kamil Malshy , Omer Sadeh , Tareq Aro , Valentin Shabataev , Azik Hoffman , Michael Mullerad , Gilad E. Amiel
Published: February 2022

Introduction: Robotic partial nephrectomy (RPN) is a relatively safe nephron sparing surgery (NSS) approach for the treatment of small renal masses (cT1). However, a major perioperative complication is extensive bleeding and blood loss necessitating blood transfusion. This complication is most challenging during the intraoperative setting and requires proper tumor bed closure. Recently several biological tissue adhesives have been tested to decrease intraoperative bleeding. A novel adhesive, Starsil® Hemostat is a plant-derived polysaccharide that can be applied directly to a bleeding wound to achieve hemostasis. The aim of our current study was to perform an evaluation of the safety and efficacy of this novel hemostat in patients undergoing RPN. Methods: This prospective single arm study included twenty patients with T1a-T1b renal masses who underwent RPN between the years 2017-2018. Renal masses were classified according to size, exophytic/endophytic properties and anatomic location into low, moderate and high complexity cases as described by the R.E.N.A.L nephrometry score. Starsil® Hemostat was applied by a feeding tube through a laparoscopic port after tumor excision. Perioperative data were collected, including blood loss during surgery, blood product transfusion rates, short and long-term adverse events and surgeon satisfaction using a visual analog scale (VAS 1-10). Results: Twenty RPN surgeries were completed using the Starsil® Hemostat. The average age was 61.8 ± 14.3. Average maximal tumor diameter was 3.8 cm (range 1.5-5.7). The calculated mean R.E.N.A.L nephrometry score was 8.4 (range 5-12). Mean blood loss during surgery was 346 mL (range 50-1400 mL). Mean surgeon satisfaction (VAS 1-10) with bleeding control was 8.3, when recorded 24 hours post operation. In 17/20 procedures (85%), bleeding control was good (VAS 9-10) and only 2 patients required blood transfusion. None of the patients developed an allergic reaction. No adverse events related to the adhesive product were noted in the post-surgical follow up period. Conclusion: Tumor bed closure during NSS with the adhesive STARSIL® Hemostat is safe, feasible and easy to use. It has the potential to reduce blood loss and transfusion rate in patients undergoing RPN.
KIT and PDGFRA inhibitor avapritinib (BLU-285) overcomes ABCB1- and ABCBG2-mediated MDR in cancer cells
Authors: Pranav Gupta , Yunali V. Ashar , Qiu-Xu Teng , Zining Lei , Bryan Chen , Sandra E. Reznik , John N.D. Wurpel , Zhe-Sheng Chen
Published: February 2022

The development of multidrug resistance (MDR) due to the overexpression of ATP-binding cassette (ABC) transporters remains one of the major obstacles to the success of chemotherapy in clinics. It is of paramount importance to identify novel drug combinations that could inhibit the multidrug efflux of ABC transporters and enhance the chemo-sensitivity of substrate anticancer drugs. In this study, we evaluated avapritinib, a KIT and PDGFRA blocker, for its reversal effects on the drug sensitivity of ABCB1 and ABCG2 overexpressing cells. Our results show that avapritinib significantly enhanced the cytotoxicity of the substrates of both ABCB1 and ABCG2. Mechanistic studies revealed that avapritinib enhances the intracellular accumulation of the substrates of ABCB1 or ABCG2 by directly decreasing their efflux from the cells overexpressing ABCB1 or ABCG2. Moreover, avapritinib did not change the expressional levels or translocation of ABCB1 or ABCG2 protein from the cell membrane to the cytoplasm and stimulates the ATP cleaving activity of both ABCB1 and ABCG2. Taken together, our results open new avenues for the use of avapritinib as cancer chemotherapy, when used in combination with the substrates of ABCB1 or ABCG2.
Immunotherapy in pediatric brain tumors: considerations, challenges and future directions
Authors: Eline S. Kruithof , Jasper van der Lugt , Esther Hulleman
Published: February 2022

Tumors of the central nervous system (CNS) are the main cause of cancer-related death in children. While improvements in survival rates for various childhood cancers have been obtained over the last decades, little progress has been made for pediatric brain tumors. In addition, current conventional treatment gives rise to severe long term toxicity, which underpins the burning need for the development of novel therapeutic modalities. Immunotherapy was shown to be successful in both adult solid tumors and pediatric hemato-oncology, and may be an option for pediatric CNS malignancies. However, pediatric brain tumors have a strong immunosuppressive microenvironment, which is considered a major hurdle for effective immunotherapy. The low mutational burden of these tumors may compromise immunotherapy for this patient group even further. The possibility to directly apply the current immune modulating therapies directly into the tumor, however, opens new options for immunotherapy in this population. This review covers immunotherapeutic approaches including immune checkpoint inhibition, chimeric antigen receptor T (CAR-T) cell therapy, therapeutic cancer vaccines, and oncolytic virotherapy. We review their effect on the immunosuppressive tumor microenvironment, summarize current trials, and discuss future directions. We conclude that immunotherapy holds promise for children with CNS malignancies, especially when combined with different (immune) therapeutic strategies.
Right ventricular outflow tract endocardial unipolar substrate mapping: implications in risk stratification of Brugada syndrome
Authors: Letsas Konstantinos P. , Vlachos Konstantinos , Efremidis Michael , Dragasis Stylianos , Korantzopoulos Panagiotis , Tse Gary , Liu Tong , Bazoukis George , Niarchou Panagioula , Prappa Efstathia , Sacher Frederic , Hocini Meleze , Baranchuk Adrian
Published: February 2022

Brugada syndrome (BrS) is a complex arrhythmogenic disease displaying electrical and micro-structural abnormalities mainly located at the epicardium of the right ventricular outflow tract (RVOT). It is well-known that fibrosis, fatty infiltration, inflammation and reduced gap junction expression have been demonstrated at the epicardial anterior aspect of the RVOT providing the arrhythmogenic substrate for ventricular arrhythmic events in BrS. A number of models have been proposed for the risk stratification of patients with BrS. Endocardial unipolar electroanatomical mapping is an emerging tool that has been reintroduced to identify and quantify epicardial electrical abnormalities. Interestingly, current findings correlate the presence of large-sized endocardial unipolar electroanatomical abnormalities with either ventricular fibrillation inducibility during programmed ventricular stimulation or symptom status. This review aims to present existing data about the role of endocardial unipolar electroanatomical mapping for the identification of RVOT epicardial abnormalities as well as its potential clinical implications in risk stratification of BrS.
Mobilizing artificial intelligence to cardiac telerehabilitation
Authors: Su Jin , Zhang Ye , Ke Qi-qi , Su Ju-kun , Yang Qiao-hong
Published: February 2022

Cardiac telerehabilitation is a method that uses digital technologies to deliver cardiac rehabilitation from a distance. It has been shown to have benefits to improve patients’ disease outcomes and quality of life, and further reduce readmission and adverse cardiac events. The outbreak of the coronavirus pandemic has brought considerable new challenges to cardiac rehabilitation, which foster cardiac telerehabilitation to be broadly applied. This transformation is associated with some difficulties that urgently need some innovations to search for the right path. Artificial intelligence, which has a high level of data mining and interpretation, may provide a potential solution. This review evaluates the current application and limitations of artificial intelligence in cardiac telerehabilitation and offers prospects.
“Absent” unilateral pulmonary arteries aren't absent, but disconnected. Review of the current literature based on 4 cases
Authors: Krasemann Thomas , Dalinghaus Michiel , van Beynum Ingrid , Bogers Ad , van den Berg Gert
Published: February 2022

Background: Disconnected unilateral pulmonary arteries are frequently misdiagnosed as “absent”. They typically arise from the base of the innominate artery and are fed by an aberrant arterial duct. If diagnosed early enough, they can be reconnected with catheter techniques even after closure of this aberrant duct. Consecutive surgical anatomical correction at a later stage is possible. Methods: Four cases illustrate the anatomical findings on computed tomography and angiography, all show an outpouching at the base of the brachiocephalic artery. Results: The therapeutic approach consisted of stenting of the aberrant ductus and consecutive surgery. In the oldest patient, 13 years, such an approach was impossible. Conclusion: If identified early in life, disconnected pulmonary arteries can be recruited with catheter techniques, and reconnected surgically at a later stage. It is not yet known if this approach prevents pulmonary damage, which is frequently seen in older untreated patients.
COVID-19 and the long-term cardio-respiratory and metabolic health complications
Authors: Ashton Ruth , Ansdell Paul , Hume Emily , Maden-Wilkinson Tom , Ryan Declan , Tuttiett Esme , Faghy Mark
Published: February 2022

Severe acute respiratory syndrome coronavirus type-2 (SARS-CoV-2) transmission continues to impact people globally. Whilst the acute symptoms and management strategies are well documented, millions of people globally are experiencing a prolonged and debilitating symptom profile that is reported to last months and even years. COVID-19 is a multi-system disease however the magnitude of the effects and its associated legacy is presently not well understood. Early reports indicate that multidisciplinary approaches between clinical and non-clinical entities are needed to provide effective and rehabilitative patient support pathways and restore pre-COVID-19 quality of life and functional status. Accordingly, this review provides a summary of the impact on cardiovascular, inflammatory, respiratory, and musculoskeletal function following an acute COVID-19 infection along with the prolonged effects of long-COVID.
Comparison of diagnostic accuracy of immediate angiography derived residual quantitative flow ratio after bioresorbable scaffold and drug eluting stent implantation
Authors: Li Zhengwei , Zhan Jiachen , Han Jia , Fu Guosheng , Jin Chongying
Published: February 2022

Background: Quantitative flow ratio (QFR) is a novel angiography derived fractional flow reserve (FFR) technique. However, its diagnostic accuracy has only be validated in native coronary lesions but not in vessels after bioresorbable scaffold (BRS) implantation. This study aims to evaluate the diagnostic accuracy of residual QFR in coronary vessels immediately post-BRS implantation. Methods: This is a retrospective, two center, validation cohort study. 73 stable angina patients who received at least one de novo lesion of an everolimus eluting stent (EES)/BRS implantation with subsequent residual FFR assessment were screened. Patients with aorta-ostial stenoses, bridge vessels at the distal segment of targeted vessels, acute coronary syndrome, previous coronary artery bypass grafting, age <18 years, lack of ≥2 final angiographic projections were excluded. Contrast QFR assessment was performed blinded to FFR assessment. Results: A good correlation (r = 0.680, p < 0.001) was found between residual QFR and FFR. In the EES implantation cohort, a good correlation (r = 0.769, p < 0.001) was found between residual QFR and FFR, and a moderate correlation (r = 0.446, p = 0.038) in the BRS cohort. The area under the Receiver operator characteristic (ROC) curve for detecting FFR ≤0.86 was 0.883 for all patients. Conclusion: Residual QFR assessment after BRS implantation is feasible, and has a moderate correlation and agreement with residual FFR. QFR may be a promising tool similar to FFR to evaluate post-BRS effect.
Natural products from traditional Chinese medicine for the prevention and treatment of heart failure: progress and perspectives
Authors: Xu Linhao , Chen Liuying , Gu Gaoyang , Wang Yi , Xu Yizhou , Zhong Yigang
Published: February 2022

Heart failure (HF) is the end stage of several cardiovascular diseases with high mortality worldwide; however, current chemical drugs have not beneficial effect on reducing its mortality rate. Due to its properties of multiple targets components with multiple targets, natural products derived from traditional Chinese medicine (TCM) have exerts unique effects on the amelioration of the clinical symptoms of HF, yet, TCM is not widely used in the clinic since the potential therapeutic targets have not been fully investigated. Therefore, in this review, we briefly summarized the pathophysiological mechanism of HF and reviewed the published clinical evaluations of TCM and natural products from Chinese herbs to treat HF. Then, the therapeutic potential and the underlying mechanisms by which the natural products from Chinese herb exert their protective effects were further summarized. We concluded from this review that natural products from Chinese herbs have been shown to be more effective in treating HF by targeting multiple signaling pathways, including anticardiac hypertrophy, antifibrotic, anti-inflammatory, antioxidative and antiapoptotic activities. However, the major limitations of these compounds is that there are a lack of large scale, multicenter, randomized and controlled clinical trials for their use in treatment of HF, and the toxic effects of natural products from Chinese herbs also needed further investigation. Despite these limitations, further clinical trials and experimental studies will provide a better understanding of the mechanism of natural products from Chinese herbs and promote their wide use to treat HF.
Relationship between plasma Neuregulin-1 and cardiac function in patients with ST-elevation myocardial infarction
Authors: Haller Paul M , Gonçalves Inês F , Acar Eylem , Jäger Bernhard , Pilz Patrick M , Wojta Johann , Huber Kurt , Kiss Attila , Podesser Bruno K
Published: February 2022

Background: Neuregulin-1 (NRG-1) is a stress-mediated transmembrane growth factor. Reduced myocardial damage and higher NRG-1 levels upon treatment with remote ischemic conditioning (RIC) has been described in rats. However, the role of NRG-1 in patients with acute myocardial infarction (MI) is unknown. Thus, we conducted a post hoc analysis of a randomized controlled trial that tested RIC in patients with MI scheduled for primary percutaneous coronary intervention (PCI). Methods: Blood was drawn from 30 patients before RIC/PCI, within 1 hour, 4 days and 1 month later. Median left ventricular ejection fraction (LVEF) in the overall study population following MI was 48.5%. Results: NRG-1 plasma levels decreased significantly following PCI/RIC and remained decreased up to 1 month following MI (p < 0.0001). We observed no association of NRG-1 with other variables, including total ischemic time, LVEF or RIC. Conclusions: Thus, we identified NRG-1 may be independently affected by MI. However, further large clinical trials are warranted to clarify this hypothesis.
Attitudes and behavioral intentions of aortic dissection survivors towards exercise: an application of the health action process approach framework
Authors: Feng Danni , Huang Sufang , Lang Xiaorong
Published: February 2022

Background: Exercise can help patients with aortic dissection (AD) control blood pressure, prevent further progression of AD, promote mental health, improve the prognosis of cardiovascular disease, and improve their overall quality of life. However, it is not clear what the attitudes and behavioral intentions of AD survivors are towards exercise. Methods: This exploratory qualitative research was based on the Health Action Process Approach (HAPA) theory to explore the cognition, attitude, motivational factors, behavior intention, barriers and facilitators of exercise in patients with AD. Face-to-face and telephone semi-structured interviews were conducted in 24 AD patients from the Department of Cardio-Vascular Surgery of third-grade Class A hospitals in Wuhan, China from April 2021 to June 2021. The patient’s current stage of behavior was evaluated according to the Patient-Centered Assessment and Counseling for Exercise (PACE) questionnaire. Results: Among the 24 participants interviewed, 9 (37.5%) were in the pre-intention stage, 8 (33.3%) were in the intention stage, and 7 (29.2%) were in the action stage. The three groups were significantly different in terms of their history of previous cardiac surgery (Fisher’s exact test, p = 0.043) and in the type of interview conducted (Fisher’s exact test, p < 0.001). In-patients with a history of cardiac surgery were more likely to be in the pre-intention stage (post-hoc test, p < 0.05). Patients from different stages had different structures. AD patients in the pre-intention stage were more likely to express risk perception and negative results for exercise. The self-efficacy of this group was often low, and lacked exercise intention and clear action plans (post-hoc test, p < 0.05). Conclusions: More attention should be paid to in-patients with a history of cardiac surgery, including health advice on exercise after discharge and promotion of changes in their health behavior. Guidelines based on the available exercise data in AD patients should be established to provide recommendations for individualized exercise programs. This should provide a basis for promoting patient rehabilitation and improving postoperative quality of life.
Effect of Process Temperature on Nickel Powder Production using Electrodeposition Method in NiSO4-NiCl2-H3BO3 Solution
Authors: Wahyuningsih Tri , Sudiyanto Anton , Sudaryanto Sudaryanto , Samuel Reinhart , Kalimasawa Rajadwa , Mawarda Mei Iftita , Pujiyulianto Eko
Published: February 2022

This paper aims to know the effect of process temperature on nickel powder production using the electrodeposition method in 500 ml of NiSO4-NiCl2-H3BO3 solution. The temperatures that were varied were 27?C, 40?C, and 50?C. The processing time was 15 minutes, and the current density was 2.2 A. The difference in the effect of temperature will be explained by the weight of the metal powder produced in the electrodeposition process. The powder results were then analyzed using an optical microscope, and the experiment that produced the highest powder weight would be further analyzed using a Scanning Electron Microscope (SEM) to characterize the morphology and grain size of nickel powder. The chemical composition was analyzed using Energy Dispersive X-Ray (EDX). The results show that the weight of nickel powder after electrodeposition is 0.58 g, 0.49 g, and 0.46 g for 27?C, 40?C, and 50?C, respectively. The most weights of nickel powder is produced from 27?C. The powder that is produced at 27oC has a smaller size and is uniform. The morphology of nickel powder is irregular with an average powder size range is 1-5 ?m. The higher current efficiency occurs at 27oC with the current density of 2.4 A/dm2
Noise Level Measurement to Reduce the Risk of Injury with the Internet of Things and Ergonomic Approach
Authors: Berlianty Intan , Rachmawati Dyah
Published: February 2022

The noise caused by the sound of machinery can hurt the work environment. Sound exposure that is above the threshold causes health risks, premature fatigue, and loss of concentration. Workers must control the noise level they receive. It takes a tool where workers can monitor the noise level they receive through sensors attached to themselves and take preventive action when the noise threshold will be reached. This can be done using the internet of things approach to expand internet connectivity that is connected continuously. The purpose of this research is to create a system in the workplace that can monitor noise conditions, which can be set remotely based on Arduino so that the data generated can be real-time. This will provide comfort for workers and can reduce the adverse effects of noise. The final result of the study shows that the Internet of Things system has worked well and can identify noise levels and provide feedback to workers through the received signal when the noise threshold is reached.
Pertumbuhan Biji Teratai (Nymphaea pubescens Willd.) pada Kondisi Asam dan Lamanya Pencahayaan Alami
Authors: Nisa Chatimatun , Ismuhajaroh B.N
Published: February 2022

Lotus is a water plant that thrives in the swamp waters of South Kalimantan. These plants in some areas are rapidly decreasing due to expansion, urbanization, industrialization, and other land uses that affect their habitat. The germination and growth of lotus seeds are very dependent on the state of the surrounding environment, especially the level of acidity and lighting from sunlight. This study aims to determine the effect of acidity and the duration of natural lighting on the growth of lotus seeds. The study was conducted at the Laboratory of Agricultural Biology, Faculty of Agriculture ULM from March to June 2016. The design used was a Separate Plot Design in a Randomized Block Design, as the main plot was the acidity level of water consisting of 11 levels and as a subplot was the lighting duration consisting of 5 levels with two replications. The results showed that lotus seeds can grow from media which have an acidity level (pH) 3-3.5 and a base pH of 7.5-8. Seeds can germinate and grow in both dark and bright conditions, but treatment with a long exposure time of 7 and 24 hours of light is the best.
PENDAPATAN DAN RISIKO USAHATANI PADI ORGANIK DAN NON ORGANIK DI KARANGASEM, KETAPANG, SUSUKAN, KABUPATEN SEMARANG
Authors: Rahayu Mayasari Dwi , Yuliawati Yuliawati
Published: February 2022

The main commodity of crops that most contributes to agricultural development is rice.           The purpose of this research was to determine differences in income, differences in the value of production and income risk, as well as the effect of production factors on the risk of production of organic and non-organic rice farming in Karangasem, Ketapang Village, Susukan District, Semarang Regency. The sampling technique is simple random sampling. Determination of the number of samples with the Slovin formula, obtained 89 farmers as respondents consisting of 44 organic farmers and 45 non-organic farmers. Income differences were analyzed using the average difference test, to determine differences in the value of production risk and income using the coefficient of variation (CV), while to determine the effect of production factors on production risk using multiple linear regression analysis. The results showed that organic rice farming income (Rp. 7,872,844) was greater than non-organic rice farming income (Rp 4,963,953) with a difference (Rp 2,908,891) and was significantly different. Based on the value (CV), the risk of organic rice farming production is 0.27 higher than the value (CV) of non-organic rice farming 0.21. The value (CV) of non-organic rice farming income risk is 1.01 higher than the value (CV) of organic rice farming of 0.85. Production factors that influence the risk of organic rice farming production are labor, and for non-organic rice farming is synthetic fertilizer.
Dinamika Populasi Mikroba dan Reduksi Serat Kasar pada Dekomposisi Awal Pengomposan Limbah Sapi Potong
Authors: Marlina Eulis Tanti , Badruzzaman Deden Zamzam , Harlia Ellin , Hidayati Hidayati , Susilawati Iin
Published: February 2022

Dekomposisi awal memiliki peran penting dalam proses pengomposan.   Penelitian ini bertujuan untuk menentukan dinamika populasi mikroba dan degradasi serat kasar selama proses dekomposisi awal. Limbah ternak pada umumnya memiliki rasio karbon dan nitrogen yang rendah sehingga diperlukan penambahan jerami padi sebagai sumber karbon. Penelitian ini menggunakan tiga perlakuan rasio C/N: 20, 25, dan 30. Perubahan suhu, pH, jumlah total bakteri, jumlah actinomycetes, jumlah kapang diamati selama 7 hari proses dekomposisi awal.  Kadar lignin, selulosa, dan hemiselulosa diamati pada akhir dekomposisi awal. Hasil penelitian menunjukkan bahwa rasio C/N 30 menghasilkan proses dekomposisi tertinggi, dengan fase termofilik terjadi pada hari ke 2 dengan suhu tertinggi 57oC dan pH 8,79. Temperatur mencerminkan proses dekomposisi yang tinggi melalui aktivitas mikroba dalam mendekomposisi bahan organik. Total jumlah bakteri dan actinomycetes yang dicapai pada fase termofilik berturut-turut 179 x 1011 cfu/g dan 87 x 105 cfu/g. Kapang berkembang pada suhu mesofilik pada hari ke 5 dan volume total tertinggi mencapai 48 x 1011 cfu/g pada hari ke 6. Proses dekomposisi awal mampu mereduksi lignin sebesar 30,57%. Hasil penelitian menunjukkan bahwa dinamika populasi mikroba dipengaruhi oleh ketersediaan nutrisi dalam substrat yang dijelaskan oleh rasio C/N. Pertumbuhan bakteri dan aktinomycetes tertinggi terjadi pada suhu termofilik sementara kapang berkembang pada suhu mesofilik. Kandungan lignin dan hemiselulosa pada substrat menurun.
DAYA TAHAN HIDUP BENIH IKAN NILA (Oreochromis niloticus) DALAM PENGANGKUTAN MENGGUNAKAN GALON AIR
Authors: Bakrie Restu Yuda , Olgani Siky
Published: February 2022

Penelitian ini dilakukan sejak berangkat dari BBI Gohong sampai desa Tewang Rangkang dengan waktu tempuh 5 jam 10 menit melalui tranportasi darat. Tujuan Penelitian ini untuk mengetahui daya tahan hidup (sintasan) benih ikan nila ukuran 2-3 cm bila diangkut menggunakan wadah galon air dengan kepadatan 280 ekor/galon tanpa diberi oksigen murni. Percobaan menggunakan rancangan acak lengkap dengan 3 perlakuan dan 3 ulangan. Hasil penelitian memperlihatan bahwa sintasan (SR) benih ikan nila setelah pengangkutan menunjukan perbedaan yang sangat nyata (P˃0,01). SR tertinggi pada perlakuan C = 100% (pengangkutan menggunakan kantong plastik diisi air dan oksigen murni dengan perbandingan 1:2 dengan kepadatan tebar 280 ekor. Sedangkan SR terendah pada Perlakuan B = 84,76% Pada tingkat kepadatan 280 ekor benih/10 liter air tanpa penambahan oksigen.
PERTUMBUHAN DAN HASIL TANAMAN TOMAT (Lycopersicum esculentum MILL.) PADA PEMBERIAN PUPUK ZN DAN JARAK TANAM YANG BERBEDA
Authors: Dewi Nazari Alvera Prihatini , Rusdiansyah Rusdiansyah , Meklin Siregar Ary Puja , Rahmi Abdul
Published: February 2022

Tomato (Lycopersicum esculentum Mill.) is a plant that is rich in benefits, but the yield is still low, some of which are due to a lack of nutrients, one of which is micro nutrient zinc, and improper plant spacing. The research was carried out to determine: 1) the best dose of Zn fertilizer and the right plant spacing; 2) the interaction between Zn fertilizer dosage and plant spacing; 3) the relationship (correlation) between the two observed variables. The research was conducted from July to October 2018 in Teluk Dalam Village, Mulawarman Village, Tenggarong Seberang District, Kutai Kartanegara Regency. The 4x3 factorial experiment was arranged in a Randomized Complete Block Design with three replications. The first factor was the dose of Zn fertilizer, consisting of four levels, namely 0.00; 3.00; 6.00; and 9.00 kg Zn ha-1. The second factor was plant spacing, consisting of: 50 cm x 50 cm; 60 cm x 50 cm; 70 cm x 50 cm. Data were analyzed using analysis of variance, followed by the LSD test at the 5% level. Correlation analysis was used to determine the relationship between two quantitative variables. The results showed that the effect of Zn fertilizer dosage was significantly different on plant height and plant age at first harvest, number of fruit per plant, fruit fresh weight per plant, harvest frequency, and fruit fresh weight per hectare, but not significantly different on plant height and age plants at flowering and the number of branches per plant. The effect of plant spacing was significantly different, on the other hand, the interaction was not significantly different on all observed variables.  The best dose of Zn fertilizer is 6.00 kg ha-1 with fruit fresh weight 25.16 Mg ha-1 and the best plant spacing is 70 cm x 50 cm  with fruit fresh weight 25.18 Mg ha-1.  The results of the correlation analysis showed that fruit fresh weight per hectare had a positive correlation with the number of fruit, fruit fresh weight per plant, and the frequency of harvest with the correlation coefficient (r), respectively 0.7350; 0.8190; and 0.6316, but negatively correlated with plant age at flowering and first harvest, namely -0.2552 and -0.3292.
Introduction
Authors: Banerjee Supurna , Gerharz Eva
Published: February 2022

While questions focused around social, economic, and physical movement have long been central to human lives, state policies, and economic regimes, the ‘mobility turn’ in academic scholarship has often seen a straightforward association of mobility as an upward trajectory mitigating socioeconomic inequality, as well as equating physical movement emerging from migration with mobility. Here, however, we argue that the relationship between migration and mobility is hardly so automatic, and needs to be considered in its complexities and contradictions. Rather than uncritically celebrating mobility, we consider it as a lens through which disruptions, inequalities, differential access, and the role of identities can be understood.
“Who Leaves Home If There is a Choice?”
Authors: Banerjee Supurna
Published: February 2022

The Dooars tea plantations in India were colonial enterprises set up through recruiting a migrant workforce from Central India. Against the background of the crisis in the Indian tea industry in the early 2000s, and the resulting migration of workers to the cities to join various casual workforces, this article questions the dualities in the framework of migration/displacement and aspiration/desperation. Through mapping the migration decisions of women workers from the plantations, the article traces the ways in which aspiration often follows from migration rather than predating it. Inheriting a history of displacement as migrant labor brought from Central India, the aspiration expressed is often that of belonging. The article then interrogates how the narratives of displacements feature in narratives of aspiration. The migration strategies are not uniform among all the women, but vary across their life stages and accordingly the possibilities and limitations post-migration differ.
Role of News and Current Affairs Channels in Creating Political Awareness Among Youth: A Case Study of Lahore City
Authors: Kaukab Fizza , Pasha Saadia Anwar , Ali Sana
Published: February 2022

Today, electronic media are playing an essential role in altering public opinion and political structure in a country.The role of electronic media is specifically significant in Pakistan as Pakistan has a larger and more vibrantly active Media landscape. The study also investigates the relevant effects of media content on Pakistani youth. The researcher employed the case study method and randomly selected a sample of n= 300 respondents from three public and three private sector universities in Lahore. The results indicated that Pakistani youth have good media exposure and frequently watch political discussion-based programs. Respondents also revealed that different news and current affairs channels affect the political efficacy of the youth and general population in Pakistan. Thus the research concluded that youngsters watch news and current affairs channels, no matter how biased that content is. Political Talk shows are much more prevalent,especially during election campaigns and other political situations.Further, the research discussed the limitations and made recommendations for future studies accordingly.
On generalized pseudo-projective curvature tensor of para-Kenmotsu manifolds
Authors:   Institute University of Technology Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bophal, India, Goyal A. , Pandey G. ,   Tulsi College, Anuppur, India, Pandey M.K. ,   Institute University of Technology Rajiv Gandhi Proudyogiki Vishwavidyalaya, Bophal, India
Published: February 2022

The object of the present paper is to generalize pseudo-projective curva-ture tensor of para-Kenmotsu manifold with the help of a new generalized(0,2) symmetric tensorZintroduced by Mantica and Suh. Various geo-metric properties of generalized pseudo-projective curvature tensor of para-Kenmotsu manifold have been studied. It is shown that a generalized pseudo-projectivelyφ-symmetric para-Kenmotsu manifold is an Einstein manifold
Geometry of bilinear forms on the plane with the octagonal norm
Authors:   Kyungpook National University, Daegu, South Koreea, Kim Sung Guen
Published: February 2022

LetR2o(w)be the plane with the octagonal norm with weight 0< w,w6= 1‖(x,y)‖o(w)= max{|x|+w|y|,|y|+w|x|}.In this paper we classify all extreme, exposed and smooth points of the closedunit balls ofL(2R2o(w)) andLs(2R2o(w)),whereL(2R2o(w)) is the space of bi-linear forms onR2o(w),andLs(2R2o(w)) is the subspace ofL(2l2∞,θ) consistingof symmetric bilinear forms.
Preservation of Lipschitz constants by some generalized Baskakov and Szász-Mirakjan operators
Authors:   Transilvania University of Brasov, Romania, Talpau Dimitriu Maria
Published: February 2022

In this paper, we consider a Stancu type generalization of Baskakov opera-tors and Sz ́asz-Mirakyan operators and we prove the preservation of Lipschitzconstants by these operators
Monotonicity formulae and F-stress energy
Authors:   Relizane University, Algeria, Djaa Nour Elhouda , Mohamed Cherif Ahmed ,   Mascara University, Algeria, Zegga Kaddour ,   Mascara University, Algeria
Published: February 2022

The goal of this work is the application of the f-stress energy of differ-ential forms to study the generalized monotonicity formulae and generalizedvanishing theorems. We obtain some generalized monotonicity formulas forp-formsω∈Ap(ξ), which satisfy the generalizedf-conservation laws, withf∈C∞(M×R) satisfying some conditions
A numerical indirect method for solving a class of optimal control problems
Authors:   Ferdowsi University of Mashhad, Iran, Ghanbari Reza , Ghorbani-Moghadam Khatere ,   Ferdowsi University of Mashhad, Iran, Nezhadhosein Saeed ,   Payame Noor University, Teheran, Iran
Published: February 2022

In this paper, a numerical indirect method based on wavelets is proposedfor solving the general continuous time-variant linear quadratic optimal con-trol problem. The necessary optimality conditions are applied to convert themain problem into a boundary value problem, as a dynamic system. Thenew problem, using two discrete schemes, Legendre and Chebyshev wavelets,is changed to a system of algebraic equations. To demonstrate the efficiencyof the proposed method two analytical and two numerical examples are given
The Relationship of Agility and Balance Tests Results of Young Female Skaters with Competition Scores in Figure Skating
Authors:   Department of Motric Performance, Faculty Transilvania University of Brasov, Romania, IONESCU A. , IONESCU V. ,   Interdisciplinary Doctoral School, Transilvania University of Brasov, Romania
Published: February 2022

The study aimed to highlight the relation between the performance registered by female skaters in agility and balance tests with their competition scores. Within our research, we applied three standardised tests designed to assess the athletic abilities that support on-ice skills development from Standardised Testing of Athleticism to Recognise Skaters (S.T.A.R.S.), consisting of one agility test (the Hexagon Test) and two balance tests (the Stork Test with eyes open and with closed eyes). The research was conducted on a group of 30 female skaters from Romania and Turkey during August-September 2019, with the age range from 10 to 12 years (x=10.87, SD= 0.73). The study showed that there is a significant correlation between the agility test (p=0.046) and the balance test with opened eyes (p= 0.043). Still, there was no significant relevance between the closed eyes balance test (p=0.192) and the scores earned in competitions by skaters. The results of the study aimed to guide coaches in choosing the proper tests for evaluating their skater's performance
The Impact of Extreme Sports on the Individual and Society: A Short Introduction
Authors:   Alexandru Ioan Cuza University of Iași, RUSU O. , RUSU D. ,   Vasile Pavelcu Techologic Special High School, Iasi
Published: February 2022

Extreme sports (ES) have developed and won the interest of individuals to practice and watch, all over the world. The need to build personal identity, to live one's own experiences, to look for stimulating emotions were the mechanisms for creating and disseminating motor action "differently". Also, a series of societal changes have contributed to changes in social models, value systems, behaviors of social actors. The media was an important vector. The impact of ES targets a series of socio-cultural, economic and political influences, psycho-physical, with both positive and negative consequences. The borderline lifestyle, appreciating the quality of life, a strong identity is features of the new social actor who practices ES.
The Influence of the Development of Specific Resistance through the Game Method on the Optimization of the Defensive Phase in the U17 Junior Football
Authors:   Departament of Motric Performance”, TransilvaniaUniversity of Braşov, SIMION G.
Published: February 2022

In this article, the author intends to conduct a comparative analysis of the results of the experiment in initial and final games for signs of efficiency of U17 junior footballers playing in defense. Inresearchstartedfromthepremisethatthedevelopmentofspecificresistance by the game method will lead to optimize the competitive players. The experiment was conducted in two U17 junior team. The results of the study conducted experimental group were better than those of the control group, the improved efficiency defense. Analysis of recorded data confirms research program used thus verified.
Contributions to the Evaluation of Physical Training for Students Specialised in Alpine Skiing
Authors:   Department of Physical Education and Special Motricity, Transilvania University of Braşov, GROSZ W.R.
Published: February 2022

The research approach consisted in the implementation of new tests in the physical training evaluation of the students from the Faculty of Physical Education and Mountain Sports from Brașov, in the third year of Bachelor in alpine skiing. The subjects of the research were ten students of FEFSM Brașov. The research activity took place during the 14 weeks of the first semester of the academic year 2018-2019. The objective was to participate and achieve good performances at the National University Ski & Snowboard Championship in 2019, slalom and giant slalom events. The initial testing was performed on October 5, 2018, and the final one on January 18, 2019. In the period between the tests, sports training programs were implemented that aimed primarily at developing speed motor quality in all its forms and coordination skills. The research results highlight both the progress of all subjects and the very good results obtained in the targeted ski events, national university champion titles and rankings among the top six places.
INTERVENTION IN THE TRAINING PROCESS AT JUNIOR BIATHLETES AFTER INCREASING EFFORT CAPACITY
Authors:   Faculty of Physical Education and Mountain Sports, Transilvania University of Brasov, PELIN B.I. , BONDOC-IONESCU D.
Published: February 2022

High performance involves leading the sports training by individualizing both the means of training and the recovery process. The periodization of sports training, by intensity, respectively workload was intensively studied, in order to highlight the main forms of training, in units of time, which favor the increase of effort capacity. The aim of this research is to monitor the training process of junior biathletes after scheduling the process with very high effort parameters. The results of the research prove that the most efficient shooting and competition results of a junior biathlete is conditioned by the adaptation of the human body at maximum efforts.
The Efficiency of Kinetic and Hydrokinetic Recovery Programs among Patients with Traumatic Shoulder Pathologies
Authors:   Department ME1—Faculty of Medicine in English, George Emil Palade University of Medicine, Pharmacy, Science and Technology from Targu Mures, Romania, SZABO D.A. , VĂDUVA O. ,   George Emil Palade University of Medicine, Pharmacy, Science and Technology from Targu Mures, Romania, MUNTEANU R.M. ,   George Emil Palade University of Medicine, Pharmacy, Science and Technology from Targu Mures, Romania,
Published: February 2022

The research objectives were to highlight the importance and the role of hydrotherapy and physical therapy exercises on patients with traumatic shoulder pathologies. The research was conducted on twenty subjects, aged between 34 and 71. The initial and final evaluation included active and passive spectrum of movement assessment, muscle strength assessment, visual analogy scale, Shoulder Pain and Disability Index (SPADI). The research showed that both groups managed to regain their active range of motion during a three-week rehabilitation program. The conclusions of our research demonstrate the effectiveness of both physiotherapy and hydrotherapy exercise
The Role of Players as Innovators
Authors:   Department of Motric Performance, Transilvania University of Braşov, TURCU I. , COSTIN D.E. ,   Department of Individual Sports and Kinetotherapy, Dunărea de Jos University of Galați., PĂSĂRIN L.D. ,   Department of Theory and Methodology of Motor Activities, University of Craiova.
Published: February 2022

Sport teaches you to fight for your goal and not to be harmed in the moments of balance. The psyche feeds on the desire for recognition, selftranscendence and progress; consequently, once the taste for small victories has settled and the desire to overcome barriers exists, the ambition to achieve the set goals appears. Ambition means pursuing a goal and the desire to do everything in your power to achieve it. In the paper "The role of players as innovators" we aimed to present first of all the social dimension of sport, why it has become so important nowadays, as well as the reasons why we consider athletes to be innovative. In the last part are presented a series of athletes considered innovators or pioneers, each in the sport they practice, because they managed to stand out and have exceptional results.
STUDY ON THE INFLUENCE OF ALIMENATION AND PHYSICAL ACTIVITY ON BODY WEIGHT DURING THE COVID - 19 PANDEMIC PERIOD
Authors:   Department of Physical Education and Sports, University of Pitesti, BUTNARIU M.
Published: February 2022

The paper presents a study on the influence of alimentation and physical activity on body weight during the Covid 19 pandemic period. Body weight management is often difficult nowadays, as we are increasingly sedentary and therefore we fail to consume the energy resulting from eating. The methods we used were: literature analysis, questionnaire survey, graphic and tabular method. The questionnaires were completed online by 30 students from the Professional Conversion Program Physical Education and Sports and master students from the Faculty of Sciences, Physical Education and Sports. After analyzing the results, we noticed that there is no stable and decisive correlation between the diet and the increase or decrease of the Body Mass Index.
ANALYTICAL STUDY ON THE DYNAMIC OF PHYSICAL, FUNCTIONAL AND MOTRICAL DEVELOPMENT TO BEGINNER PRACTITIONERS OF KARATE SHOTOKAN, CADETS AND JUNIORS
Authors:   University, Faculty of Physical Education and Sports, Galați, România, COJOCARU M. , MEREUȚA C. ,   Department of Individual Sports and Kinetotherapy, University of „Dunărea de Jos”, România, IORDAN D.A. ,   Department of Individual Sports and Kinetotherapy, University of „Dunărea de Jos”, România
Published: February 2022

The purpose of this research is centered on the need to know the physical and motor development of cadets and juniors, shotokan karate practitioners, in order to promote the more efficient organization of sports training lessons. In this process we started from the following hypotheses: the pace of physical development of the cadets and juniors is different from one year to another, the pace of motor development of the cadets and juniors is different from one year to another, the ability to adapt to effort of beginner practitioners of Karate Shotokan, cadets and juniors, is constantly improving and differs from one year of study to another. The application of the tests, the investigation and the rigorous interpretation of the results argue the hypotheses and validate the objectivity and correctness of the experimental action.
Study of Coordination Development through Practicing Karate at the Age of 12-14 Years
Authors:   Dunărea de Jos University of Galați, Faculty of Physical Education and Sport, Petre C. , ENOIU R. ,   Departament of Motric Performance”, Transilvania University of Braşov
Published: February 2022

This study on the development of coordination through practicing karate aims to present and demonstrate a method of coordination development through learning the basic technical procedures of traditional karate. The experiment performed on children aged between 12 and 14 years highlights the importance of coordination, which underlies their development. The practical activity specific to this martial art highlighted the development of the main components of coordination but also of the aspects related to self-control, respect, ability to concentrate and last but not least, patience.
MINDFULNESS AND EMOTIONAL CONTROL SKILLS – PREMISES FOR SUCCESSFUL PROFESSIONAL PATH IN SECONDARY SCHOOL LEVEL IN ROMANIA
Authors:   School  of  Advanced  Studies  of  the  Romanian  Academy,  ”Constantin-Rădulescu  Motru”  Institute  of Philosophy and Psychology, Romanian Academy, LUNGU Maylla , ANGHEL R.E. ,   National College Vlaicu Vodă, Curtea de Argeş, România, MISTREANU G.D. ,   County Centre for Educational Resources and Assistance, Prahova, Romania, NEACSU E.L. ,   County Centre for Educational Resources and Assistance, Argeş, Romania, PAVEL N.M. ,   County Centre for Educational Resources and Assistance, Argeş, Romania
Published: February 2022

The research aims to provide a psycho-social perspective on the results of including personal development disciplines in the curriculum of secondary school students in Romania. Youngsters between 17 and 21 years old, from various secondary schools in the country, filled-in between February and June, 2020 the Mindfulness Attention Scale and Emotion
MANIFESTATION OF STRESS IN ORGANISATIONS
Authors:   Transilvania University of Brașov, DOBRESCU Ada-Ioana
Published: February 2022

This article presents the theroretical framework and the results of research conducted in an organisation of airship and spaceship manufacturers with respect to the concept of stress. The main objective of the research is to underline the way in which employees of this company succeed in overcoming the tension present in the workplace
MEDICINE AND MANAGERIALISM IN ITALY: EVIDENCE FROM A STUDY ON HEALTH MANAGEMENT TRAINING
Authors:   Polytechnic University of Marche, SOFRITTI Federico
Published: February 2022

Management training for doctors has become crucial with the introduction of market-inspired logics in the Italian national healthcare system. In this frame, the paper presents the main findings of a study with a twofold aim: providing an overview of health management training system by analyzing the Italian training provision; investigating perceptions and opinions of medical doctors involved in management courses. Results suggest, on the one hand, the heterogeneity of the Italian management training system and, on the other, a gradual reframing of medical professionalism.