bluuebunny/crossref_metadata_2025 huggingface dataset:
A study on the pathogenic microbes and antibiotic-sensitivity patterns in urinary tract infection among diabetes patients at a tertiary care hospital in Central Kerala
Authors: Goswami Tribeni , Krishnamurthy Mathew Samuel , Varghese Sangeetha Merrin
Published: December 2022

Background:

Diabetes mellitus (DM) has become a global disease that is affecting millions of people, and currently, India has about 50 million patients. Urinary tract infections (UTIs) have long been recognized as a significant problem in patients with DM. This study aimed to find out the pathogenic microorganisms and antibiotic sensitivity patterns for UTI in diabetes patients.

Methodology:

This was a cross-sectional study conducted in the Department of Microbiology at a tertiary care hospital. The duration of the study was for 10 months. Diabetic status was confirmed as per the recommended diagnostic criteria. The identification of the bacterial isolates and antimicrobial sensitivity was carried out by conventional or Vitek-2 compact system. Data were entered in Microsoft Excel and were analyzed using the SPSS version 20. Variables were represented by the frequency and percentage analysis.

Results:

There were 59 positive urine cultures in diabetes patients from January 2021 to October 2021, and the highest number of patients belong to the >70 years' age group. Escherichia coli was the predominant organism isolated and was most sensitive to carbapenems.

Conclusions:

In our study, the elderly female population were found to be the most vulnerable group. The highest sensitivity was observed in carbapenem which can be used for empirical treatment in admitted patients.
Comparison of sublingual misoprostol with intramuscular oxytocin in active management of the third stage of labor
Authors: Charaya Harsha , Soni Monica , Gupta Jeevika , Nayak Asmita
Published: December 2022

Background:

Postpartum hemorrhage (PPH) is the most common cause of maternal mortality worldwide. Significant numbers are preventable, especially in low-resource settings. Active management of the third stage of labor (AMTSL) is a key denominator. The present study aimed to compare sublingual misoprostol with intramuscular oxytocin in AMTSL to search for an easy and effective alternative for low-resource settings.

Materials and Methods:

A prospective randomized comparative study was conducted, where the subjects were registered over 1 year extending from May 2020 to June 2021 including 200 patients admitted to the labor room with term pregnancy with a period of gestation between 37 and 42 weeks and were divided into two groups, Group A and Group B receiving intramuscular oxytocin and sublingual misoprostol, respectively.

Results:

Sublingual misoprostol was equally effective compared with intramuscular oxytocin in the prevention of PPH. There were no statistical differences in the duration of the third stage of labor, need for additional uterotonics, need for manual removal of placenta, and need for blood transfusion in the two groups.

Conclusion:

Sublingual misoprostol appeared to be as effective as intramuscular oxytocin in the AMTSL and may be an alternative, especially in low-resource settings.
Assessment of breeding sites and seroprevalence of dengue in an urban area of Puducherry – A community-based study
Authors: Velavan A , Shashikala  , Anitha Patricia , Stalin P. , Kumar R. Arun , Purty Anil J.
Published: December 2022

Background:

Dengue virus infection is an important global public health issue. India is one of the high-burden countries with the resurgence of dengue in recent years. Surveillance based on hospital data can be misleading. Seroprevalence studies in the community are extremely useful in measuring the extent of transmission. This community-based study was done to identify the breeding sites of the Aedes mosquito and measure the seroprevalence of dengue infection in an urban area of Puducherry.

Methodology:

A cross-sectional study was done for 6 months in an urban area of Puducherry to assess the breeding sites for dengue and to find the serological prevalence of dengue. House-to-house visits were done in the study area to collect details on sociodemographic data, environmental data, and breeding sites for dengue. Blood samples were obtained from all willing participants aged 9 years and above to detect specific immunoglobulin G antibodies to dengue virus by enzyme-linked immunosorbent assay.

Results:

The seroprevalence of dengue infection was found to be 8.3%. Flower vase with water 72 (18%), animal water container 32 (8%), roof gutter/sunshades, 25 (6.3%), and open water storage tanks 18 (4.5%) were the most commonly prevalent breeding sites in the study area. The houses with potential breeding sites, such as roof gutters and sunshades, were significantly associated with the prevalence of dengue seropositivity among the study participants.

Conclusion:

The seroprevalence was found to be relatively low in the study area and the potential breeding sites for dengue were identified.
The tangled web of dyslipidemia and cancer
Authors: Neshat Sina , Rezaei Abbas , Farid Armita , Sarallah Rojin , Javanshir Salar , Ahmadian Sarina , Chatrnour Gelayol , Daneii Padideh , Heshmat-Ghahdarijani Kiyan
Published: December 2022

Cancer is a primary cause of mortality around the world and imposes a significant physiological, psychological, and financial burden on patients. Lipids regulate cell cycle progression and affect cell proliferation, migration, and apoptosis. Therefore, alterations in serum lipid levels might contribute to carcinogenesis. In this article, we review the relationships between triglyceride (TG), total cholesterol, high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C) levels and different types of cancer. Then, we examine the association between cancer and familial hypercholesterolemia. Finally, we evaluate the impact of statins on different types of cancer. Increased total cholesterol has been reported to increase cellular proliferation and angiogenesis in tumors and inhibit apoptosis. Increased LDL-C has been reported to induce inflammation and increase susceptibility to oxidative damage. HDL-C has anti-oxidation, anti-inflammatory, and antiproliferative properties. Increased levels of serum TG can induce oxidative stress and a chronic inflammatory state and therefore contribute to the proliferation and progression of cancer cells. Statins decrease downstream products of cholesterol synthesis that are crucial in cell proliferation and growth. Thus, lipid components can have prognostic value in cancer and management of serum lipid levels through lifestyle changes and medical therapy can be beneficial in cancer prevention and treatment.
Coronary artery calcification
Authors: Shabestari Abbas Arjmand , Mahdavi Arash , Abrishami Alireza , Alahyari Sam , Molla Mahdieh
Published: December 2022

Background:

The aim of this study was to evaluate the effect of coronary artery calcification on disease severity and prognosis in patients with coronavirus disease-2019 (COVID-19).

Materials and Methods:

One hundred and forty-one patients with COVID-19 were included in this study. The severity of pulmonary involvement and calcification of coronary arteries were assessed by computed tomography scan and calcification was classified by two methods: Weston and segmental. In both the methods, patients were divided into three groups with scores of 0, 1–6, and 7–12, which are called groups 1, 2, and 3, respectively.

Results:

The mean age of patients was 54.26 ± 14.55. Difference in score of pulmonary involvement was reported to be significant between deceased and discharged patients (11.73 ± 5.26 and 7.28 ± 4.47, P = 0.002, respectively). In Weston score system, the chance of recovery of Group 1 patients was significantly higher than Group 3 (odds ratio [OR] =6.72, P = 0.05, 95% confidence interval [CI] =1.901–50.257). Similar results were observed in the segmental scoring system (OR =6.34, P = 0.049, 95% CI =1.814–49.416). Despite the higher chance of severe disease in patients with coronary artery calcification, this increase was not statistically significant in either Weston or segmental methods (OR =0.47, P = 0.23 and OR =0.85, P = 0.79, respectively).

Conclusion:

Coronary artery calcification in patients with COVID-19 has a significant association with poor prognosis. However, no significant relationship was observed between this issue and the severity.
Economic impact of acute respiratory disease pandemics
Authors: Hadian Shirin Alsadat , Rezayatmand Reza
Published: December 2022

Background:

The economic impact of acute respiratory disease pandemics has yet to be specifically systematically reviewed. The aim of this scoping review is to identify and classify the economic impacts and its values and ranges.

Materials and Methods:

We conducted a literature search across three key databases using an extensive list of keywords. Then, we included studies which explored direct and indirect costs as well as broader economic impact associated with different nine acute respiratory diseases, i.e., pandemic and seasonal influenza, avian influenza, equine influenza, swine influenza, severe acute respiratory syndrome, coronavirus disease 2019, Middle East respiratory syndrome, H1N1, and H7N9.

Results:

We included 62 studies in English language between 1987 and 2020, mostly from the countries of East Asia and Pacific pertinent. We classified the economic impact into 5 main categories and 18 subcategories. The main categories were macroeconomic impacts, impacts on health cost, industry, businesses and trade, and education.

Conclusion:

Respiratory disease pandemics have widely impacted different sectors of economy such as the direct cost on macroeconomic, providing and receiving health services, disease management, industries, business and trade, education, and indirect costs due to productivity losses. However, lots of the reviewed studies were unable to quantify the actual economic cost of these impacts. This made it challenging to conduct any kind of quantitative comparison of the results. A key priority for future research is to develop standard methods to quantify the broader economic costs of respiratory disease pandemics. Understanding the total economic impact of respiratory disease pandemics is a key step to inform national and international priority setting for disease prevention and pandemic control interventions.
Cardiovascular implications of the COVID-19
Authors: Hamidian Maliheh , Ansari Ramin , Zarshenas Mohammad Mehdi , Foroughinia Farzaneh
Published: December 2022

Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2, has rapidly spread worldwide and has been infected more than 219 million individuals with 4.55 million deaths worldwide as of September 2021, causing a pandemic. Preexisting cardiovascular (CV) comorbidities such as hypertension, diabetes, and coronary artery disease seem to be associated with greater severity of infection, worse prognosis, and higher mortality. Moreover, COVID-19 can contribute to CV complications, including acute myocardial injury, arrhythmia, acute coronary syndrome, and venous thromboembolism, emphasizing the importance of precocious detection and implementation of optimal therapeutic strategies. This review provides an overview of evidence-based data of CV complications of COVID-19, focusing on their management strategies, as well as potential cardiac adverse effects and drug interactions, due to off-label and investigational drugs used for the treatment of COVID-19.
Growth Inhibitory Activity of Brassica oleracea var. Alboglabra on Human Gastric Cancer Cells
Authors: Ngo Dai-Hung , Nguyen Hoang Nhat Minh , Nguyen Thi Nhat Hang , Nguyen Thi Lien Thuong , Ngo Dai-Nghiep , Vo Thanh Sang
Published: December 2022

Objectives:

The aim of this study is to investigate anticancer activity of Brassica oleracea var. alboglabra (BOA) against the proliferation of BGC-823 human gastric cancer cells.

Materials and Methods:

B. oleracea var. alboglabra was extracted by ethanol 98% at a solid-to-liquid ratio of 1:8, (w/v) for 24h at room temperature. The cytotoxic effect of vegetables was examined by MTT assay. The migration of the cancer cells was conducted by wound healing assay and visualized under an inverted microscope. The mRNA expression level was quantified by real time PCR.

Major Findings:

It was found that ethanol extract of BOA exhibited the inhibitory activity against the proliferation of BGC-823 cells at IC50 value of 217.6 ± 2.8 µg/ml. Moreover, the treatment of BOA extract at concentration of 100 µg/ml for 24 h significantly suppressed the migration of gastric cancer cells into the gap as compared to the untreated cell group. Notably, the cytotoxic effect of BOA extract on human gastric cancer cells was found due to induction of apoptosis, mediating the up-regulation of caspase-8, -9, -3, and Bax in cancer cells.

Conclusion:

These results indicated that B. oleracea var. alboglabra have the potential inhibitory activity against the development of gastric cancer.
Alleviation of Hepatotoxicity by Natural Chelators in Lead-induced Poisoning in Rats
Authors: Nausheen Quadri Neha , Ali Syed A.
Published: December 2022

Aims:

The study intends to monitor the consequences of lead on the body, its reversal by natural chelators (chitosan and chitosamine), and comparison of monotherapy with the combination using the synthetic ones.

Materials and Methods:

A total of 42 albino Wistar male rats (200–250 g) were divided into seven groups (n = 6). Except for the first group which received sodium acetate 1 g/L (drinking water, vehicle control), all groups received lead acetate 0.4 mg/kg body weight peroral (p.o.). Group II (toxic) received merely lead acetate, whereas the third and fourth groups received 0.2 g/kg (p.o.) of chitosan and chitosamine, respectively. Groups V–VII received ethylenediaminetetraacetic acid (EDTA) 495 mg/kg (p.o.). In addition, the sixth and seventh groups received chitosan and chitosamine (0.2 g/kg) (p.o.), respectively. The hematological, biochemical, oxidative stress parameters, number of porphobilinogen molecules formed/h/mL, and histopathology were assessed. The data obtained were compared using analysis of variance following Tukey’s test.

Results:

The results revealed a statistically significant reduction in the hemogram parameters, antioxidant enzymes, porphobilinogen molecules and an increase in oxidative stress, liver biomarkers along with malondialdehyde in the toxic group in comparison with control and treatment groups. The histopathological findings revealed a significant improvement in the chitosan and chitosamine treatment groups when compared with the toxic group, whereas the results obtained from combination therapy with respect to its monotherapy were most significant than the monotherapy alone.

Conclusion:

Chitosan and chitosamine are found to improve hemato- and hepatotoxicity by chelation and can be used as potent detoxifiers in heavy metal toxicities.
A low peripheral perfusion index can accurately detect prolonged capillary refill time during general anesthesia
Authors: Iizuka Yusuke , Yoshinaga Koichi , Nakatomi Takeshi , Takahashi Kyosuke , Yoshida Kyoko , Sanui Masamitsu
Published: December 2022

Background:

Capillary refill time (CRT) is the gold standard for evaluating peripheral organ perfusion; however, intraoperative CRT measurement is rarely used because it cannot be conducted continuously, and it is difficult to perform during general anesthesia. The peripheral perfusion index (PI) is another noninvasive method for evaluating peripheral perfusion. The PI can easily and continuously evaluate peripheral perfusion and could be an alternative to CRT for use during general anesthesia. This study aimed to determine the cutoff PI value for low peripheral perfusion status (prolonged CRT) by exploring the relationship between CRT and the PI during general anesthesia.

Methods:

We enrolled 127 surgical patients. CRT and the PI were measured in a hemodynamically stable state during general anesthesia. A CRT >3 s indicated a low perfusion status.

Results:

Prolonged CRT was observed in 27 patients. The median PI values in the non-prolonged and prolonged CRT groups were 5.0 (3.3–7.9) and 1.5 (1.2–1.9), respectively. There was a strong negative correlation between the PI and CRT (r = −0.706). The area under the receiver operating characteristic curve generated for the PI was 0.989 (95% confidence interval, 0.976–1.0). The cutoff PI value for detecting a prolonged CRT was 1.8.

Conclusion:

A PI <1.8 could accurately predict a low perfusion status during general anesthesia in the operating room. A PI <1.8 could be used to alert the possibility of a low perfusion status in the operating room.

Trial Registration:

University Hospital Medical Information Network (UMIN000043707; retrospectively registered on March 22, 2021, https://center6.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000049905).
COVID-19 associated Mucormycosis (CAM)
Authors: Gupta Anju , Kayarat Bhavana , Gupta Nishkarsh
Published: December 2022

Mucormycosis once considered a rare disease with an incidence of 0.005 to 1.7 per million, has become one of the greatest menaces during the coronavirus disease (COVID-19) pandemic. India alone has contributed to nearly 70% of the global caseload of COVID-associated mucormycosis (CAM) and it had even been declared as a notifiable disease. Second wave of COVID-19 pandemic saw a steep rise in the incidence of mucormycosis and these patients have been presenting to anesthesiologists for various surgical procedures due to its primary or secondary sequelae. Rhino-orbito-cerebral mucormycosis (ROCM) is the commonest manifestation and is caused by Rhizopus arrhizus. Injudicious use of corticosteroids in vulnerable patients could have been a major contributing factor to the sudden rise in ROCM during the pandemic. Concerns related to anesthetic management include COVID-19 infection and post COVID sequalae, common presence of uncontrolled diabetes mellitus, possibility of difficult mask-ventilation and/or intubation, various drug therapy-associated adverse effects, and interaction of these drugs with anesthetic agents. Thorough preoperative optimization, multidisciplinary involvement, perioperative care, and vigilance go a long way in improving overall outcomes in these patients.
Awareness, preconception, and fear of epidural analgesia among childbearing women in Saudi Arabia
Authors: Aldammas Fatma , Alshihri Abdulrhman A. , Alhowaish Rayan K. , Alotaibi Basheer M. , Alhamdi Abdullah F. , Algharbi Faisal F. , Alhassoun Hamad Y. , Alhamad Mohammed H. , Alhaddab Abdullah A.
Published: December 2022

Background:

Labor pain is one of the most excruciatingly painful sensations a woman can have. A woman's attitude toward childbirth might be influenced by her lack of understanding of the birth process and the pain she experiences throughout labor and delivery. The control of pain is an important aspect of appropriate obstetrical care. Our study aims to measure the level of awareness, preconception, and fear of epidural analgesia (EDA) among childbearing women.

Methods:

An observational cross-sectional, hospital-based study was conducted using a self-administered questionnaire. The study included all pregnant women who were attending an obstetrical clinic for routine antenatal follow-up at King Khalid university hospital in Riyadh, Saudi Arabia, during the month of August 2022. They were asked about five main parts that tapped their awareness, preconception, and fear of EDA. Data were analyzed by SPSS version 26 using descriptive methods, including mean, frequency, and percentage, and also Pearson's correlation coefficient for regression analysis to find the correlation between socio-demographics and awareness and between awareness and fear.

Results:

Participants in our study included 202 childbearing women. Most women, about 113 (55.9%), participating in the study were aged between 25 and 34 years old. The majority of the participants of this study were Saudi, about 196 (97.0%). In terms of education, 120 (59.4%) of the participants graduated from university. One hundred and forty two (70.3%) of the participants had a monthly income of less than 10000. When it comes to parity, the majority of participants, about 102 (50.5%), have had more than two pregnancies. The average percentage of awareness among the participants showed 45.9%, with an insignificant very moderate correlation between parity and awareness (r = -0.088, P = 0.107); women's knowledge, income, and age were also insignificantly related to awareness. Also, the result showed a moderate level of fear with an average percentage of 44.6% among the participants, with a moderate correlation between awareness and fear with a value of (r = 0.184, P = 0.004).

Conclusion:

This study results demonstrate a good level of desirability toward using EDA for labor pain, yet there is a limited level of preconceptions and a low level of awareness and knowledge about EDA. In addition, the results showed that the average percentage of fear is 44.6%. Therefore, we suggest that more awareness, knowledge, and guidance about EDA should be provided to pregnant women through antenatal clinics. Furthermore, educational campaigns should be made to dispel misconceptions and fears about EDA.
On the moments of the moments of the characteristic polynomials of Haar distributed symplectic and orthogonal matrices
Authors: Assiotis Theodoros , Bailey Emma , Keating Jonathan
Published: December 2022

We establish formulae for the moments of the moments of the characteristic polynomials of random orthogonal and symplectic matrices in terms of certain lattice point count problems. This allows us to establish asymptotic formulae when the matrix-size tends to infinity in terms of the volumes of certain regions involving continuous Gelfand–Tsetlin patterns with constraints. The results we find differ from those in the unitary case considered previously.
Long term dynamics of the subgradient method for Lipschitz path differentiable functions
Authors: Bolte Jérôme , Pauwels Edouard , Ríos-Zertuche Rodolfo
Published: December 2022

We consider the long-term dynamics of the vanishing stepsize subgradient method in the case when the objective function is neither smooth nor convex. We assume that this function is locally Lipschitz and path differentiable, i.e., admits a chain rule. Our study departs from other works in the sense that we focus on the behavior of the oscillations, and to do this we use closed measures, a concept that complements the technique of asymptotic pseudotrajectories developed in this setting by Benaïm–Hofbauer–Sorin. We recover known convergence results, establish new ones, and show a local principle of oscillation compensation for the velocities. Roughly speaking, the time average of gradients around one limit point vanishes. Various cases are discussed, providing new insight into the oscillation and the stabilization phenomena.
Improved decoupling for the parabola
Authors: Guth Larry , Maldague Dominique , Wang Hong
Published: December 2022

We prove an

(\ell^2,L^6)

decoupling inequality for the parabola with constant

(\log R)^{c}

. In the appendix, we present an application to the sixth-order correlation of the integer solutions to

x^2+y^2=m

.
Bases for upper cluster algebras and tropical points
Authors: Qin Fan
Published: December 2022

It is known that many (upper) cluster algebras possess different kinds of good bases which contain the cluster monomials and are parametrized by the tropical points of cluster Poisson varieties. For a large class of upper cluster algebras (injective-reachable ones with full rank coefficients), we describe all of their bases with these properties. Moreover, we show the existence of the generic basis for them. In addition, we prove that Bridgeland’s representation-theoretic formula is effective for their theta functions (weak genteelness).

Our results apply to (almost) all known cluster algebras arising from representation theory or higher Teichmüller theory, including quantum affine algebras, unipotent cells, double Bruhat cells, skein algebras over surfaces, where we change the coefficients if necessary so that the full rank assumption holds.
Non-equilibrium multi-scale analysis and coexistence in competing first passage percolation
Authors: Finn Thomas , Stauffer Alexandre
Published: December 2022

The main contribution of this paper is the development of a novel approach to multi-scale analysis that we believe can be used to analyse processes with non-equilibrium dynamics. Our approach will be referred to as
multi-scale analysis with non-equilibrium feedback
and will be used to analyse a natural random growth process with competition on

\mathbb{Z}^d

called
first passage percolation in a hostile environment
(FPPHE) that consists of two first passage percolation processes

\mathit{FPP}_1

and

\mathit{FPP}_{\lambda}

that compete for the occupancy of sites. Initially,

\mathit{FPP}_1

occupies the origin and spreads through the edges of

\mathbb{Z}^d

at rate 1, while

\mathit{FPP}_{\lambda}

is initialised at sites called
seeds
that are distributed according to a product of Bernoulli measures of parameter

p\in(0,1)

, where a seed remains dormant until

\mathit{FPP}_1

or

\mathit{FPP}_{\lambda}

attempts to occupy it before then spreading through the edges of

\mathbb{Z}^d

at rate

\lambda>0

. Two fundamental challenges of FPPHE that our approach is able to handle are the absence of monotonicity (for instance, adding seeds could be beneficial to

\mathit{FPP}_1

instead of

\mathit{FPP}_\lambda

) and its non-equilibrium dynamics; such characteristics, for example, prevent the application of a more standard multi-scale analysis. As a consequence of our main result for FPPHE, we establish a coexistence phase for

d\geq3

, answering an open question of Sidoravicius and Stauffer (2019). This exhibits a rare situation where a natural random competition model on

\mathbb{Z}^d

observes coexistence for processes with
different
speeds. Moreover, we are able to establish the stronger result that

\mathit{FPP}_1

and

\mathit{FPP}_{\lambda}

can both occupy a
positive density
of sites with positive probability, which is in stark contrast with other competition processes.
Carleson embedding on the tri-tree and on the tri-disc
Authors: Mozolyako Pavel , Psaromiligkos Georgios , Volberg Alexander , Zorin-Kranich Pavel
Published: December 2022

We prove a multi-parameter dyadic embedding theorem for the Hardy operator on the multi-tree. We also show that for a large class of Dirichlet spaces in the bi-disc and the tri-disc, this proves the embedding theorem of those Dirichlet spaces of holomorphic functions on the bi- and tri-disc. We completely describe the Carleson measures for such embeddings. The result below generalizes the embedding result of Arcozzi et al. from the bi-tree to the tri-tree and from the Carleson–Chang condition to the Carleson box condition. One of our embedding descriptions is similar to the Carleson–Chang–Fefferman condition, and involves dyadic open sets. On the other hand, the unusual feature is that the embedding on the bi-tree and the tri-tree turns out to be equivalent to the one box Carleson condition. This is in striking difference to works of Chang–Fefferman and the well-known Carleson quilt counterexample. Finally, we explain the obstacle that prevents us from proving our results on poly-discs of dimension four and higher.
Expansion of harmonic functions near the boundary of Dini domains
Authors: Kenig Carlos E. , Zhao Zihui
Published: December 2022

Let

u

be a harmonic function in a

C^1

-Dini domain such that

u

vanishes on an open set of the boundary. We show that near every point in the open set,

u

can be written uniquely as the sum of a non-trivial homogeneous harmonic polynomial and an error term of higher degree (depending on the Dini parameter). In particular, this implies that

u

has a unique tangent function at every such point, and that the convergence rate to the tangent function can be estimated. We also study the relationship of tangent functions at nearby points in a special case.
Function theoretic characterizations of Weil–Petersson curves
Authors: Bishop Christopher J.
Published: December 2022

The Weil–Petersson class is the closure of the smooth closed curves in the Weil–Petersson metric on universal Teichmüller space defined by Takhtajan and Teo. We give some new characterizations of this class of curves and some new proofs of previously known characterizations. In particular, we give a new, more geometric characterization of the conformal weldings of such curves and characterize the curves themselves in terms of Peter Jones’s

\beta

-numbers.
Wymagania kompetencyjne stawiane kadrom kultury. Analiza ogłoszeń o pracy
Authors: Mizera-Pęczek Patrycja , Grzesiak Lena
Published: December 2022

Competence Requirements for the Staff of Cultural Institutions. An Analysis of Job Advertisements

Analysing the employees’ competencies is relevant both from the organisation’s and individuals’ perspective, because it allows – for example – to predict emerging competency gaps in organisations, design training offers tailored to the organisation’s needs and employees’ expectations, or to better match people’ professional tasks with organisational culture. One of the methods for obtaining information about competence requirements is the analyse of job advertisements published by the selected employers. This article focuses on the competence requirements set by employers representing cultural organisations. Its purpose is to showcase the competencies expected from the staff of cultural institutions in Poland from the perspective of job advertisements. The article presents the results of the analysis of 127 job advertisements published on the “Pracuj w Kulturze” webiste from the 31st of January to the 1st of February 2022. The analysis included the requirements regarding the following: knowledge (both formal and non-formal), skills and employee attitudes desired by the employers.
The Phenomenon of Women in Managerial Positions in Public Cultural Institutions
Authors: Góral Anna
Published: December 2022

The purpose of this paper was to explore the organisation of a support system for the professional development of women in public cultural institutions. The deliberations in this paper are based on qualitative research. The research included biographical interviews with ten women who currently work in managerial positions in public cultural institutions in Poland. This research strategy made it possible to get to know the experiences of women who reached managerial positions in their professional career in culture and to attempt an explanation of the observed phenomena as they are seen by people who were part of the system. Research has shown that the support system for the professional development of women in public cultural institutions seems to be largely based on informal solutions initiated within the personal support networks of women who are part of the system, its foundation being interpersonal relations. The main contribution of the paper is the interesting dataset gathered. Moreover, the proposed rhizome metaphor enriches the field of organizational research by suggesting new ideas that contribute to expanding on how we can see and perceive the complexity and variation in organizational phenomena of women in leadership positions and therefore opening up new interpretations and directions.
Czas w przestrzeni organizacyjnej: perspektywa kadr kultury
Authors: Halska-Pionka Bogna
Published: December 2022

Time in Organizational Space: The Perspective of Employees of a Cultural Organization

Cultural institutions are exceptional spaces where time gains new meanings. By interacting with stakeholders, responding to the needs declared by potential recipients, and setting trends – they become active participants in the process of shaping and giving meaning to cultural heritage, of which one of the most important components is also time. Therefore, it turns out that employees of cultural institutions are responsible not only for managing themselves but for managing the processes taking place within an organization as well, moreover they are also obliged to closely observe the dynamically changing world.

This text aims to diagnose and describe the importance of time – according to employees – in working in cultural institutions. To prepare the article, the author used the research conducted for the purposes of her thesis entitled Time management – aporia or utopia? In line with the adopted methodological

strategy, the method of narrative collage was used, consisting of collecting fictional stories from employees of cultural organizations. The analysis of the obtained research material made it possible to diagnose the challenges faced by cultural institutions, related to, inter alia, inadequate financing, failure of taking into account the individual needs and expectations of employees and chaos in the working time organization.
Autoinflammatory undifferentiated syndrome
Authors: Tolstykh Aleksandra V. , Popova Larisa Y. , Albakasova Akmer A. , Usenkova Natalia N.
Published: December 2022

Identification of primary immunodeficiencies (PID), distinction of their nosological forms and timely admoinistered therapy for this disorders frepresent topical problems of modern immunology. According to the PID registry of the National Association of Experts in the Field of Primary Immunodeficiencies (NAEPID), as of 2021, 3617 cases of this disease were diagnosed in Russian Federation (RF). The prevalence of PID in Russian Federation is 2.48 per 100,000 population. Currently, autoinflammatory syndromes (AIS) comprise rare, genetically determined disorders. According to the NAEPID registry data, of the PID register, 541 cases of autoinflammatory syndrome (AIS) were registered in the Russian Federation (2021). Timely diagnosis of AIS is especially important in young children who have similar phenotypic signs, in order to reduce the number of deaths and prevent disability. According to the PID registry, the median diagnostic delay in Russia is 27 months. The purpose of this work is to update information about the autoinflammatory syndrome that clinicians may encounter, e.g., pediatricians, rheumatologists, hematologists and other specialists. This syndrome requires a complex differential diagnostic algorithm for clinicians and is often subject to multidisciplinary approach, involving specialists of different profile. This article describes a clinical case of a 3-year-old child S. with a diagnosis of Primary immunodeficiency: autoinflammatory syndrome, undifferentiated. The patient was diagnosed since the age of 5 months, when periodic rises in body temperature to febrile values were registered once a month. Later on, the fever episodes were observed 2 times a month. The diagnosis was made at the place of residence as secondary immunodeficiency virus-associated state (CMV infection). CMV viremia was canceled against the background of ongoing treatment, but the inflammatory attacks persisted. Molecular genetic studies did not reveal any defects. In view of poor response to NSAID therapy and prednisone prescribed at a dose of 1-1.5 mg/kg/day, he was admitted to the Dmitry Rogachev Research Medical Cemter. The child was finally diagnosed with PID, and therapy was initiated with a selective competitive inhibitor of TNFa etanercept at a dose of 0.8 mg/kg/day once a week. Hence, the autoinflammatory syndrome in children is difficult to diagnose and select therapy, and it may be unfavorable prognostically.
Changes in mucosal immunity of oral cavity upon tooth loss in patients with periodontal diseases
Authors: Malyshev Mikhail E. , Kerimkhanov Camil A. , Iordanishvili Andrey K. , Bumai Alexey O.
Published: December 2022

Partial or complete loss of teeth occurs in elderly and senile people, caused, mainly, by chronic generalized periodontitis. At the same time, the impact of presence or absence of persisting teeth and periodontium, is practically not covered in the literature as a factor of balance in the oral cavity, including local immunity of the mucous membranes. Our work concerned the changes in local immunity of the oral cavity occuring with the loss of natural teeth. We have observed 45 elderly people who were divided into 3 study groups, i.e., without inflammatory periodontal pathology (1), with periodontitis (2) and with chronic periapical inflammatory processes in the absence of periodontal inflammation (3). In order to sanitize oral cavity before the upcoming dental prosthetics, the patients of study groups 2 and 3 underwent extraction of all teeth in the upper and lower jaws. Indices of local immunity of the oral cavity in the salivary fluid of patients were assessed before surgical sanitation of the oral cavity (before the teeth extraction) and 30-35 days after removal of the last tooth. We have measured the salivary levels of secretory immunoglobulin A (sIgA) as well as pro-inflammatory cytokines, i.e., interleukin-1 (IL-1), interleukin-6 (IL-6), interleukin-8 (IL-8), tumor necrosis factor- (TNF), and anti-inflammatory cytokines, e.g., receptor antagonist of interleukin-1 (RAIL), interleukin-4 (IL-4), interleukin-10 (IL-10)), as well as contents of antimicrobial peptides in saliva (catelicidin LL-37 and alphadefensins 1-3 (HNP1-3). We have found that the development of inflammation in severe inflammatory periodontal diseases, in particular, chronic generalized periodontitis requiring tooth extraction for oral cavity sanitation is characterized by functional insufficiency of secretory immunity of the oral mucosa associated with decreased secretion of secretory immunoglobulin A and antimicrobial peptides of neutrophilic origin, as well as a shift in the salivary cytokine balance towards increased production of pro-inflammatory cytokines. Removal of teeth, as the main source of inflammation and the basis for maintenance of dysbiotic microbiome biofilm leads to elimination of inflammation and the restoration of immune balance in the oral cavity.
Issues of specific in vitro allergological diagnosis of atopic conditions
Authors: Barilo Anna A. , Smirnova Svetlana V. , Belenyuk V. D. , Savchenko Andrei A. , Borisov Aleksandr G.
Published: December 2022

There is a steady increase in the prevalence of allergic diseases of atopic origin worldwide, e.g., atopic bronchial asthma (ABA) and atopic dermatitis (AD). Identification of a causally significant allergen in allergic patients is crucial for the diagnosis, therapy and prevention of allergic diseases. Korea has developed the Allergy-Q multiplex test to detect specific IgE. Allergy-Q is based on an immunoblotting method using a nitrocellulose membrane as a solid phase for allergen immobilization and can detect allergen-specific IgE simultaneously to 107 allergens. Our aim was to conduct a comparative analysis for detectable allergen-specific IgE antibodies to food, fungal, pollen, household, epidermal allergens in blood serum by immunoblotting method using the Allergy-Q test system in patients with atopic dermatitis, atopic bronchial asthma and psoriasis.
The study included patients with atopic dermatitis (AD, group 1, n = 9), atopic bronchial asthma (ABA, group 2, n = 14) and psoriasis (PS, group 3, n = 17). The concentration of total immunoglobulin E and allergen-specific immunoglobulins of class E in blood serum to 32 most common food, fungal, pollen, household, epidermal allergens was determined by the immunoblotting method using the Allergy-Q test system (Korea).
We have found that sensitization of atopic origin was observed in all patients with AD (n = 9), in 85.7% (n = 12) of patients with atopic bronchial asthma, and in 47.1% (n = 8) of patients with psoriasis. Polyvalent sensitization was shown to prevail in all groups of the examined persons. When studying the spectrum of sensitization to food allergens, a significantly increased frequency of positive reactions to cows milk protein was found in the group of patients with AAA as compared with AD and PS groups. Among all studied groups, sensitization to the Alternaria fungi was found at the highest frequency in the group of patients with ABA. Sensitization to ragweed pollen was very common in all groups of patients. Sensitization to household and epidermal allergens in the groups with AD and AAA was noted for all studied allergens with the highest positivity rates for the feline epithelium and dog dander.
In the present study, the Allergy-Q system showed an agreement with preliminary data from a specific allergological examinations. This relationship suggests a potential for usage of the Allergy-Q immunoblotting method as a highly effective alternative to other in vitro tests for diagnosing atopy. An advantage of the Allergy-Q Multiplex Serum Allergen-Specific IgE Detection Kit is a short processing time, small amount of blood sample, and broader clinical information on the causative allergens.
PD-1 expression on T cell subsets from peripheral blood of patients with allergic diseases
Authors: Blinova Elena A. , Galdina Victoria A. , Sukhova Natalia M. , Demina Darja V.
Published: December 2022

Pathogenesis of allergic diseases is based on the activation of Th2 immune response. T cell response to antigens is known to be regulated by various co-stimulatory and inhibitory signals; inhibitory receptors include PD-1 and Tim-3 molecules. Interaction of the PD-1 receptor with its ligands leads to suppression of activation, proliferation of T cells and production of cytokines by these cells. In chronic bacterial and viral infections, increased expression of PD-1 and Tim-3 on T cells is a marker of cellular exhaustion, since the cytokine production is reduced in cells positive for these inhibitory receptors. Involvement of the co-inhibitory PD-1 receptor into pathogenesis of allergic diseases has not been sufficiently studied, and the data available from the current literature are scarce and contradictory. Therefore, the aim of our study was to evaluate the expression level of co-inhibitory PD-1 and Tim-3 receptors on CD4+ and CD8+T cells, as well as expression of PD-1 on allergen-specific Th2A cells in allergic bronchial asthma (BA) and allergic rhinitis (AR) beyond the pollination season. We used the flow cytometry method to assess immune phenotype of peripheral blood cells from blood donors and patients with allergic diseases, in order to evaluate expression of PD-1 and Tim- 3 markers. The study included 7 patients with allergic asthma, 10 patients with AR beyond the exacerbation phase, and 14 healthy, allergy-free individuals. It was found that the number of CD4+ and CD8+ cells expressing the PD-1 molecule in peripheral blood of patients with BA and AR was within the ranges of healthy individuals. A decrease in CD4+ cells expressing Tim-3 marker was observed only in the group of patients with AR which may be caused both by the absence of pollen allergens and remission of the disease. The content of allergen-specific Th2A cells (CD4+CD45RO+CD27-CRTh2+CD161+) in patients with AR and BA was increased relative to the control group, thus suggesting a pathogenetic significance of this cell population for allergic diseases. However, the level of PD-1 expression on Th2A cells, as well as on the main T cell subpopulations, was comparable to donor values. This finding may suggest that PD-1 may be considered not only a marker of exhaustion as shown for chronic viral infections. Moreover, it also may reflect the activation status of various T cell subpopulations, including allergen-specific Th2A cells in allergic conditions.
Terra arrasada
Authors: Arbarotti Alexsandro Elias , Reis Tainá
Published: December 2022

Em consonância com parte do debate estabelecido pela Sociologia Rural e pela Sociologia Ambiental - difundido, também, nos dez anos da Revista Áskesis -, objetivamos neste ensaio tratar sobre a exploração do ser humano e da natureza no processo de produção capitalista da mercadoria agrícola. O capitalismo, como organizador do tecido da vida, carrega uma lógica necropolítica, na qual estão envolvidos os habitantes do planeta, os seres vivos e os “não vivos”, isto é, no processo de produção de valor há uma mistura entre atividades humanas, extra-humana (máquinas e softwares) e da natureza. Desse modo, é preciso integrar a dimensão ecológica na compreensão das desigualdades sociais. A apropriação e exploração não é só do trabalho humano, mas também do trabalho da natureza.
liberdade acadêmica e o fazer científico
Authors: Melo Silva Beatriz , Cinquini Bruna , Passos de Lima Wormhoudt Talitha
Published: December 2022

O presente ensaio busca pensar o lugar da Sociologia na sociedade, principalmente a importância dos espaços de divulgação científica e a liberdade acadêmica. Atualmente, são recorrentes os ataques à ciência e ao fazer científico, em especial, às matérias das Ciências Humanas. Neste texto, enfatizam-se as dificuldades de estar inserido no campo da sociologia, seja como professor ou pesquisador, considerando os obstáculos para permanecer nas Universidades Públicas como pesquisadores e os entraves causados pelos ataques à ciência. O ensaio aborda a importância da Sociologia na construção de uma sociedade mais democrática, e o fato de ser essencial existirem espaços de divulgação científica, com a finalidade de construir uma análise qualificada sobre o Brasil contemporâneo.
INSTITUTIONAL HISTORY, MODERN MODEL AND DEVELOPMENT STRATEGIES OF THE CONSULAR SERVICE OF UKRAINE Book review: Consular Service of Ukraine: Formation and Development / Ed. H.M. Perepelytsia. – К.: Логос, 2018. – 440с. ISBN 978-617-7446-73-5
Authors: Tsivatyi Viacheslav
Published: December 2022

Scientific Intelligence "Consular Service of Ukraine: Formation and Development" is an original, modern and relevant scientific study, which analyzes the international political, international legal, institutional and historical features of the development and implementation of mechanisms to protect the rights of citizens in the consular sphere in a polycentric world XXI century, its effectiveness and priority in the future is clearly defined: "This book is not only about the glorious historical heritage of the Ukrainian consular service, but also about its current representatives - Ukrainian consuls who create this history and pave the future of the Ukrainian state and Ukrainian nation."