bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantitative Assessment of Ribociclib Exposure–Response Relationship to Justify Dose Regimen in Patients with Advanced Breast Cancer
Authors: Ji Yan , Darstein Christelle , Yang Shu , Quinlan Michelle , Chakravartty Arunava , Zarate Juan Pablo , Chakraborty Abhijit , Ho Yu‐Yun
Published: July 2023

Ribociclib in combination with endocrine therapy (ET) is a globally approved treatment option for patients with hormone receptor‐positive (HR+)/human epidermal growth factor receptor 2‐negative (HER2−) advanced breast cancer (ABC) and has demonstrated significantly improved overall survival (OS) in 3 phase 3 clinical trials. To justify the dose regimen and dose modification scheme for patients with ABC, the pharmacokinetic (PK), safety, and efficacy data of ribociclib were analyzed. The data of several phase 1‐3 clinical studies were pooled and analyzed to characterize the relationship between exposure (dose or PK) and efficacy (progression‐free survival (PFS), time to response, and OS) or safety (neutropenia and QT interval prolongation). The exposure–efficacy analysis showed no apparent relationship between ribociclib exposure and efficacy (PFS and OS), and efficacy analysis by dose reduction showed that patients with ABC continued to benefit from the treatment following dose reduction, supporting the starting dose of 600 mg as well as dose reductions to 400 and 200 mg. The exposure–safety analysis showed that neutropenia and QT prolongation are related to ribociclib exposure that can be effectively managed by individualized dose modification (dose reduction/interruption). Collective evidence from the exposure–response analyses for efficacy and safety support the use of ribociclib in combination with ET partners at the starting dose of 600 mg, and also the effectiveness of individualized dose reductions in managing safety, while maintaining efficacy, in patients with HR+/HER2− ABC. This analysis illustrates the utility of quantitative assessment in justifying dose selection and dose modification for oncology medicines.
Exponential stability of a transmission problem for wave equations with internal time‐varying delay and nonlinear degenerate weights
Authors: Hu Meng , Yang Xin‐Guang , Li Yanfang
Published: July 2023

This paper is concerned with a transmission problem for wave equations with internal time‐varying delay and nonlinear degenerate weights. Under some appropriate assumptions, the global well‐posedness and exponential stability are shown by the variable norm technique of Kato and the energy method, respectively.
Human aromatic amino acid decarboxylase is an asymmetric and flexible enzyme: Implication in aromatic amino acid decarboxylase deficiency
Authors: Bisello Giovanni , Ribeiro Rui P. , Perduca Massimiliano , Belviso Benny Danilo , Polverino de' Laureto Patrizia , Giorgetti Alejandro , Caliandro Rocco , Bertoldi Mariarita
Published: July 2023

Human aromatic amino acid decarboxylase (AADC) is a pyridoxal 5′‐phosphate‐dependent enzyme responsible for the biosynthesis of dopamine and serotonin, essential neurotransmitters involved in motor and cognitive abilities. Mutations in its gene lead to AADC deficiency, a monogenic rare neurometabolic childhood parkinsonism characterized by severe motor and neurodevelopmental symptoms. Here, for the first time, we solved the crystal structure of human holoAADC in the internal aldimine (1.9 Å) and in the external aldimine (2.4 Å) of the substrate analog L‐Dopa methylester. In this intermediate, the highly flexible AADC catalytic loop (CL) is captured in a closed state contacting all protein domains. In addition, each active site, composed by residues of both subunits, is connected to the other through weak interactions and a central cavity. By combining crystallographic analyses with all‐atom and coarse‐grained molecular dynamics simulations, SAXS investigations and limited proteolysis experiments, we realized that the functionally obligate homodimeric AADC enzyme in solution is an elongated, asymmetric molecule, where the fluctuations of the CL are coupled to flexibility at the edge between the N‐terminal and C‐terminal domains. The structural integrity of this peripheral protein region is essential to catalysis, as assessed by both artificial and 37 AADC deficiency pathogenic variants leading to the interpretation that structural dynamics in protein regions far from the active site is essential for CL flexibility and the acquirement of a correct catalytically competent structure. This could represent the molecular basis for pathogenicity prediction in AADC deficiency.
Momentum‐innovation recursive least squares identification algorithm for a servo turntable system based on the output error model
Authors: Liu Zhiwen , Cheng Tianji , Han Chongyang , Liu Enhai , Wang Ranjun
Published: July 2023

In this article, the parameter identification problem of the output error model is investigated under the application requirement of online parameter identification of a two‐degree‐of‐freedom servo turntable system. To eliminate the influence of colored noise in the observed output signal of the output error model on the algorithm identification accuracy, the momentum factor is introduced into the innovation term of the recursive least squares algorithm, and the momentum‐innovation recursive least squares (MI‐RLS) algorithm is proposed. Further, to improve the convergence speed and identification accuracy of the algorithm while avoiding increasing the algorithm complexity significantly, a reframed multi‐innovation strategy is introduced, and a momentum reframed multi‐innovation least squares (MR‐MILS) algorithm is developed. After analyzing the complexity of the proposed algorithms, the convergence performances of the two algorithms are verified using the theory of martingale convergence, and the results show that the reframed multi‐innovation strategy can accelerate the convergence speed of the MR‐MILS algorithm. The effectiveness of the proposed identification approach is demonstrated via simulation results.
Gesundheit wohnungsloser Menschen während der COVID-19-Pandemie
Authors: van Rüth Victoria , Hajek André , Heinrich Fabian , Ondruschka Benjamin , Püschel Klaus , Bertram Franziska
Published: July 2023

Die Lebenssituation und die Gesundheit wohnungsloser Menschen unterscheiden sich in vielerlei Hinsicht von denen der Allgemeinbevölkerung. Die Vermutung liegt nahe, dass es sich bei wohnungslosen Menschen um eine besonders vulnerable Personengruppe während der Coronavirus-Disease-2019(COVID-19)-Pandemie handelt. In dieser narrativen Übersichtsarbeit soll die aktuelle Literatur zur Gesundheit und Versorgung von wohnungslosen Menschen während der COVID-19-Pandemie zusammengefasst werden. Recherchiert wurde zwischen Dezember 2022 und Februar 2023. Neben der aktuellen nationalen und internationalen Literatur sollen insbesondere die Ergebnisse des „National survey on psychiatric and somatic health of homeless individuals“ (NAPSHI-Studie) synoptisch dargestellt werden; diese untersucht psychische und somatische Erkrankungen sowie die Versorgung wohnungsloser Menschen in Deutschland.

Wohnungslose Menschen sind häufig psychisch und somatisch erkrankt und haben einen eingeschränkten Zugang zum medizinischen Regelsystem. Versorgungseinrichtungen mit Gruppenräumen und Schlafsälen stellen ein Risiko für ein Ausbruchsgeschehen in der COVID-19-Pandemie dar. Wie vermutet, zeigten sich im Verlauf der Pandemie bei wohnungslosen Menschen häufiger als in der Allgemeinbevölkerung Hinweise für Severe Acute Respiratory Syndrome Coronavirus Type 2(SARS-CoV‑2)-Infektionen, viele davon schienen allerdings asymptomatisch zu verlaufen. Eine hohe Rate an unwissentlich infizierten wohnungslosen Menschen könnte zur Verbreitung der Viruserkrankung beigetragen haben. Trotzdem war ein unkontrolliertes COVID-19-Ausbruchsgeschehen, vor dem einige Wissenschaftler:innen zu Beginn der Pandemie warnten, nicht zu beobachten.
Crystal Structure and Characterization of the Well-Known Plasticizers Ethylene Glycol Dinitrate, Diethylene Glycol Dinitrate and Triethylene Glycol Dinitrate
Authors: Lechner J. T. , Stierstorfer J. , Klapötke T. M.
Published: July 2023

Ethylene glycol dinitrate (EGDN), diethylene glycol dinitrate (DEGDN) and triethylene glycol dinitrate (TEGDN) are used as plasticizers in propellant mixtures and have been known for more than 100 years. Despite the industrial application and the long history of these compounds, the crystal structures of all three compounds, which are liquids at room temperature, have not yet been determined. Therefore, in this work the crystal structures were determined by low-temperature X-ray diffraction and thus the bonding properties and crystal packing in the solid state could be compared. The densities at room temperature were measured by gas-pycnometry and the energetic properties were calculated using the EXPLO5 code.
Natural and Renewable Resources for New Inert and Energetic Polymeric Binders – Hazard Properties
Authors: Afsar A. , Dossi E. , Kister G. , Gaulter S. , Stennett C.
Published: July 2023

The hazard properties of new energetic binders based on β-cyclodextrin (βCD) and polyethylene glycol (PEG) units were assessed following laboratory and Energetic Materials Testing and Assessment Policy (EMTAP) protocols. Samples from 20 mg scale (single batches) to 10 g scale (multiple batches), were mixed with 1% and 2% EC stabiliser and chemically and thermally characterised. For single batches, the Rotter impact test indicated a figure of insensitiveness (FoI) of 22.7 (1% w/w EC) and 25.4 (2% w/w EC) with an average release of 1.5 cc gas in “Go” responses while the FoI of for multiple batches was 29.8, with an average release of 1.1 cc gas in “Go” responses. No ignition was recorded for single and multiple batches in any combination of mallet and anvil and no vulnerability to Electrostatic Discharge (ESD) stimuli (4.5 J). The temperature of ignition for the multiple batches were between 154.3 °C and 154.9 °C, while in train test, the multiple batches ignited and supported train (30 cm in length) steadily throughout. The nitrated βCD-PEG binders exhibited thermal stability up to 190 oC comparable to nitrocellulose and good ageing at 70 oC for 21 days in presence of 2% w/w of stabiliser. The βCD-PEG energetic binders made from green and sustainable precursors and environmentally friendly process offer innovative solutions for energetic formulations.
Implementation of Hvrb in LS-DYNA and Application to Detonation in Hemispherical Charges in Ideal Explosives
Authors: Falco S. , Chapman D. , Tyas A. , Limbu A. , Whittaker M. , Pope D. , Petrinic N. , Eakins D.
Published: July 2023

The modelling of energetic materials is usually performed within an Eulerian framework, inherently well suited to simulate fluid-like behaviour of the reaction products and the propagation of pressure waves in the surrounding fluid media (e.g. air or water). However, the Lagrangian framework becomes more attractive in the effort to reproduce the unreacted mechanical response of the material, especially as we move towards trying to capture better the response of damaged explosives. In this paper the implementation of the History Variable Reactive Burn (HVRB) model in the Lagrangian explicit software LS-Dyna is presented. The HVRB reaction rate parameters are verified against simple ratestick tests before being used to simulate the detonation of hemispherical charges from an ignition point located at the pole of the hemisphere. The numerical results are directly compared against high-speed video from the experimental tests, illustrating reasonable agreement given the simplicity of the HVRB formulation. This paves the way for developing deeper understanding by incorporating more complex reactive burn models, e.g. Damage Initiated Reaction (DMGIR), which can consider the role of mechanically induced damage upon the response of explosives.
Investigating XDT in Rocket Propellants
Authors: Gould P. J. , Ottley P. , Taylor N. , Cullis I. G. , Cornish R.
Published: July 2023

Unknown (X) to Detonation Transition (XDT) is a significant concern in the design, assessment and use of rocket motors. The threat is the motor being hit by a fragment or other projectile which is not travelling sufficiently fast to cause Shock to Detonation Transition but causes damaged propellant to spall across the bore and detonate on impact with the propellant on the other side of that bore. QinetiQ have developed, and have been using, a small scale test to determine propensity of propellant to XDT and better understand the mechanisms that cause it. The use of high speed video and other instrumentation has been critical to this effort. It is found that detonation at the second surface is always initiated away from the point of impact. X-ray imagery has revealed that the impacting fragment is retarded in materials where XDT can occur and simulations have indicated that this retardation is not due to mechanical interaction with the propellant. It is proposed that an impactinduced reaction in the propellant target produces high pressure gas, contained by an intact bulge of propellant, that provides a retarding force on the fragment and that this pressure subsequently plays a part in causing XDT when the propellant bulge impacts against the second surface.
Descriptive Characterization of High-Frequency Distortion Product Otoacoustic Emission Source Components in Children
Authors: Dreisbach Laura , Konrad-Martin Dawn , Gagner Christine , Reavis Kelly M. , Jacobs Peter G.
Published: July 2023

Purpose:

Distortion product otoacoustic emissions (DPOAEs) provide an objective assessment of cochlear function and are used for serial ototoxicity monitoring in pediatric cancer patients. DPOAEs are modeled as having distortion (near
f
2
) and reflection (near 2
f
1
-
f
2
) component sources, and developmental changes are observed in these components' relative strengths in infants compared with adults. However, little is known about source component strengths in childhood or at extended high frequencies (EHFs; > 8 kHz). Thus, the purpose of this study was to describe the effects of age and stimulus frequency on DPOAE components in children.

Method:

DPOAEs were collected with varied frequency ratios (
f
2
/
f
1
= 1.1–1.25) for a wide range of frequencies (2–16 kHz) in 39 younger (3–6 years) and 41 older (10–12 years) children with constant levels (L
1
/L
2
) of 65/50 dB SPL. A depth-compensated simulator sound pressure level method of calibration was employed. A time waveform representation of the results across various ratios was created to estimate peak pressures and latencies of each DPOAE component.

Results:

Estimated peak pressures of DPOAE components revealed the greatest differences in DPOAE sources between children occurring at the highest frequencies tested, where the peak pressure of both components was largest for younger compared with older children. Latency differences between the children were only noted at higher frequencies for the distortion component.

Conclusions:

These results suggest that DPOAE levels decrease with age and reflection emissions are vulnerable to cochlear change. This work guides optimization of protocols for pediatric ototoxicity monitoring, whereby including EHF otoacoustic emissions is clearly warranted and choosing to isolate DPOAE sources may prove beneficial.

Supplemental Material:

https://doi.org/10.23641/asha.23669214
Ventilation Mechanics
Authors: Farré Ramon , Navajas Daniel
Published: July 2023

A fundamental task of the respiratory system is to operate as a mechanical gas pump ensuring that fresh air gets in close contact with the blood circulating through the lung capillaries to achieve O2 and CO2 exchange. To ventilate the lungs, the respiratory muscles provide the pressure required to overcome the viscoelastic mechanical load of the respiratory system. From a mechanical viewpoint, the most relevant respiratory system properties are the resistance of the airways (R
aw), and the compliance of the lung tissue (C
L) and chest wall (C
CW). Both airflow and lung volume changes in spontaneous breathing and mechanical ventilation are determined by applying the fundamental mechanical laws to the relationships between the pressures inside the respiratory system (at the airway opening, alveolar, pleural, and muscular) and R
aw, C
L, and C
CW. These relationships also are the basis of the different methods available to measure respiratory mechanics during spontaneous and artificial ventilation. Whereas a simple mechanical model (R
aw, C
L, and C
CW) describes the basic understanding of ventilation mechanics, more complex concepts (nonlinearity, inhomogeneous ventilation, or viscoelasticity) should be employed to better describe and measure ventilation mechanics in patients.
ITER appears unstoppable despite recent setbacks
Authors: Kramer David
Published: July 2023

Repairs could take up to two years, but project officials believe they can perform them in parallel with the machine’s assembly. Regulatory concerns are unresolved.
Local and global visibility and Gromov hyperbolicity of domains with respect to the Kobayashi distance
Authors: Bracci Filippo , Gaussier Hervé , Nikolov Nikolai , Thomas Pascal
Published: July 2023

We introduce the notion of locally visible and locally Gromov hyperbolic domains in

C

d

\mathbb {C}^d

. We prove that a bounded domain in

C

d

\mathbb {C}^d

is locally visible and locally Gromov hyperbolic if and only if it is (globally) visible and Gromov hyperbolic with respect to the Kobayashi distance. This allows to detect, from local information near the boundary, those domains which are Gromov hyperbolic and for which biholomorphisms extend continuously up to the boundary.
Ethical considerations regarding penis transplantation surgery in transgender men—an empirical ethics study
Authors: de Haseth Kristin B , Gehrels Anne M , Widdershoven Guy , Bouman Mark-Bram , van de Grift Tim C
Published: July 2023

Background

The ongoing quest to surgically create the (nearly) ideal neophallus in transgender men has led to the continuous development of transgender medicine and the proposed introduction of penis transplantation. However, both technical and ethical issues arise when developing this treatment.

Aim

We sought to extract ethical considerations among different stakeholder groups regarding penile transplantation surgery in transgender men and to define preliminary clinical recommendations.

Methods

Three semistructured focus groups, consisting of different stakeholders, were organized to participate in discussions of ethical considerations retrieved from the ethics literature of transplantation and transgender medicine. Analysis of the results was performed according to empirical ethics.

Outcomes

Study outcomes were the identification of qualitative themes describing ethical considerations pertaining to penile transplantation in transgender men.

Results

Nineteen people participated in this qualitative study. The main domains that emerged included arguments in favor of and arguments against penile transplantation. Although the participants expressed positive attitudes toward developing this care, with acknowledgement of the current limitations stakeholders of all groups were reluctant to endorse the introduction of penile transplantation for transgender men at this point.

Clinical Implications

Under the present circumstances, all groups expressed both a wide variety of ethical considerations as well as a tendency to prefer developing alternative treatment options or improving the results of currently available treatments in relation to penile transplantation for transgender men.

Strengths and Limitations

This study was the first (empirical) study to focus on this topic and included a diversity of stakeholder perspectives. Limitations included the hypothetical nature of the discussion as well as the clinical setting in which the topic has been studied.

Conclusion

Introducing penile transplantation for transgender men, under the current circumstances, comes with a wide range of ethical considerations, which deal with personal identity, autonomy, medical risks, risk for transgender support and donor willingness, and issues regarding equality. Despite the present hesitancy to use penile transplantation, should the technical side of this treatment option develop, further research in the ethical field of penile transplantation for transgender men is recommended.
Watch-and-wait approach for inactive echinococcal cysts: scoping review update since the issue of the WHO-IWGE Expert Consensus and current perspectives
Authors: Brunetti Enrico , Tamarozzi Francesca
Published: July 2023

Purpose of review

This work aims to provide an update of knowledge on the evolution of inactive cystic echinococcosis (CE) cysts (CE4-CE5) managed by ‘watch-and-wait’, by means of a scoping review of the literature published after the publication of the WHO-IWGE (Informal Working Group on Echinococcosis) Expert Consensus document in 2010.

Recent findings

A total of 31 articles were included. Population ultrasound-based studies showed that spontaneously inactivated CE cysts represent 50.2% (95% confidence interval 38.7–61.8) of all detected untreated CE cysts, and that the prevalence of CE4-CE5 cysts tends to increase with age. Four longitudinal population-based studies showed that CE cysts naturally tend to evolve towards inactivation and that spontaneously inactivated cysts reactivate in a minority of cases. This was confirmed by four hospital-based studies, showing that spontaneously inactivated cysts reactivate rarely, while rate of reactivation is higher if inactivity was obtained posttreatment. It was not possible to drive conclusions on any difference in the clinical course of infection in immunocompromised or pregnant patients.

CE cysts tend to evolve spontaneously to inactivation over time. The published literature supports the safety of the watch-and-wait approach for inactive cysts, sparing treatment to a substantial proportion of asymptomatic patients. A regular follow-up with ultrasound of all inactive cysts is required to detect reactivations.
Neurodevelopmental outcomes in congenital and perinatal infections
Authors: Fortin Olivier , Mulkey Sarah B.
Published: July 2023

Purpose of review

Congenital infections are a major cause of childhood multidomain neurodevelopmental disabilities. They contribute to a range of structural brain abnormalities that can cause severe neurodevelopmental impairment, cerebral palsy, epilepsy, and neurosensory impairments. New congenital infections and global viral pandemics have emerged, with some affecting the developing brain and causing neurodevelopmental concerns. This review aims to provide current understanding of fetal infections and their impact on neurodevelopment.

Recent findings

There are a growing list of congenital infections causing neurodevelopmental issues, including cytomegalovirus, Zika virus, syphilis, rubella, lymphocytic choriomeningitis virus, and toxoplasmosis. Fetal exposure to maternal SARS-CoV-2 may also pose risk to the developing brain and impact neurodevelopmental outcomes, although studies have conflicting results. As Zika virus was a recently identified congenital infection, there are several new reports on child neurodevelopment in the Caribbean and Central and South America. For many congenital infections, children with in-utero exposure, even if asymptomatic at birth, may have neurodevelopmental concerns manifest over time.

Congenital infections should be considered in the differential diagnosis of a child with neurodevelopmental impairments. Detailed pregnancy history, exposure risk, and testing should guide diagnosis and multidisciplinary evaluation. Children with congenital infections should have long-term follow-up to assess for neurodevelopmental delays and other neurosensory impairments. Children with confirmed delays or high-risk should be referred for rehabilitation therapies.
Selective attention to audiovisual speech routes activity through recurrent feedback-feedforward loops between different nodes of the speech network
Authors: Wikman Patrik , Salmela Viljami , Sjöblom Eetu , Leminen Miika , Laine Matti , Alho Kimmo
Published: July 2023

Selective attention related top-down modulation plays a significant role in separating relevant speech from irrelevant background speech when vocal attributes separating concurrent speakers are small and continuously evolving. Electrophysiological studies have shown that such top-down modulation enhances neural tracking of attended speech. Yet, the specific cortical regions involved remain unclear due to the limited spatial resolution of most electrophysiological techniques. To overcome such limitations, we collected both EEG (high temporal resolution) and fMRI (high spatial resolution), while human participants selectively attended to speakers in audiovisual scenes containing overlapping cocktail party speech. To utilize the advantages of the respective techniques, we analysed neural tracking of speech using the EEG data and performed representational dissimilarity-based EEG-fMRI fusion. We observed that attention enhanced neural tracking and modulated EEG correlates throughout the latencies studied. Further, attention related enhancement of neural tracking fluctuated in predictable temporal profiles. We discuss how such temporal dynamics could arise from a combination of interactions between attention and prediction as well as plastic properties of the auditory cortex. EEG-fMRI fusion revealed attention related iterative feedforward-feedback loops between hierarchically organised nodes of the ventral auditory object related processing stream. Our findings support models where attention facilitates dynamic neural changes in the auditory cortex, ultimately aiding discrimination of relevant sounds from irrelevant ones while conserving neural resources.
CCL19, not CCL21 induces CCR7-mediated stimulation of leukemia apoptosis by targeting endosomal signaling signaling
Authors: Sun Sylvia Y , Hu Bin , Liang Alice
Published: July 2023

This manuscript has been withdrawn by bioRxiv as it was submitted and made public without the full consent of all the authors. Therefore, the authors do not wish this work to be cited as reference for the project. If you have any questions, please contact the corresponding author
Coworkers’ interpersonal justice and team citizenship behaviors: mediation of social exchange and identity and moderation of extraversion
Authors: Ohana Marc , Stinglhamber Florence , Caesens Gaëtane
Published: July 2023

Purpose

The purpose of this study is to examine the effect of coworkers’ interpersonal justice (defined as the extent to which one is treated by coworkers with dignity, courtesy and respect) on team citizenship behaviors. More precisely, the authors first test the mediating role played by both team-member exchange and team identification in this relationship. Further, they examine the moderating role of extraversion in these two mediating mechanisms.

Design/methodology/approach

Based on 134 subordinate–supervisor dyads, the authors conducted moderated multiple mediation analysis.

Findings

The results of this study showed that, for highly extraverted employees, coworkers’ interpersonal justice positively influences team citizenship behaviors because of an exchange relationship of better quality among the team members. In contrast, for employees with low or medium levels of extraversion, the positive effect of coworkers’ interpersonal justice on team citizenship behaviors is explained by their higher identification with the team.

Practical implications

This paper holds important implications for management practice in teamwork environment. Given coworkers' interpersonal justice role in determining team citizenship behaviors, the findings of this study highlight the importance of establishing a work culture where each employee treats others fairly.

Originality/value

Overall, these findings indicate that, depending on the level of employees’ extraversion, mechanisms grounded in the social exchange and the social identity perspectives act as complementary mechanisms in the team-focused justice–citizenship behaviors relationship.
Care, labour force participation and health: the case of Italy
Authors: Mussida Chiara , Patimo Raffaella
Published: July 2023

Purpose

This paper investigates the relationship between health and labour market participation considering the potential role played by the presence of children and elderly persons (with/without disabilities) in Italian households.

Design/methodology/approach

The authors use longitudinal data from the European Union Statistics on Income and Living Conditions and full-information maximum likelihood to estimate a two-equation model (one equation for labour force participation and one for health status) with instruments to address the endogeneity of the labour force participation choice. The model is estimated separately by gender.

Findings

The authors find that while the presence of children, elderly persons or both is positively associated with the health status of both genders, the presence of disabled elderly persons exerts a negative role. As for participation, interesting differences emerge. The presence of children discourages women's participation but is positively associated with men's labour force participation. Interestingly, a caring role for elderly persons without disability emerges for both genders when the presence of children is combined with that of elderly people. Gender differences are also at work for the role of childcare services and elderly and/or disabled home care/assistance.

Originality/value

The findings indicate a possible caring role for elderly persons without disabilities, neutralizing the effect of the presence of children on the labour force participation of both genders. The results also suggest that greater coverage of care services should increase the active participation of women in the labour market.
Well-being co-creation in service ecosystems: a systematic literature review
Authors: Landry Mikèle , Furrer Olivier
Published: July 2023

Purpose

Following the continued development of transformative service research and the prevalence of the service-dominant logic in services marketing literature, increased scholarly interest centers on the co-creation of service actors’ well-being. In light of this significant evolution in service research, this study aims to provide a systematic review and synthesis of the growing, fragmented body of literature on well-being co-creation in services.

Design/methodology/approach

The hybrid systematic review approach combines bibliometric and framework-based literature reviews to analyze a sample of 160 article obtained from the Web of Science database. To examine the conceptual structure of the research domain, VOSviewer is used for conducting a bibliometric coupling analysis and a keyword co-occurrence analysis. Next, a content analysis is used to explore how the extant literature addresses the key concepts of service actors’ participation in co-creation, their resource integration and well-being outcomes across the micro-, meso- and macro levels of service ecosystems.

Findings

Service actors’ participation and resource integration are key theoretical concepts for understanding well-being co-creation. Yet, a comprehensive overview of well-being co-creation across the different levels of service ecosystems is lacking due to the presence of various application contexts, levels of aggregation, theoretical backgrounds and methodological perspectives. A conceptual framework of well-being co-creation in service ecosystems is developed, highlighting the participation of multilevel service actors and suggesting priorities for further research.

Originality/value

To the best of the author’s knowledge, this paper represents a first effort to systematically review and organize growing literature on well-being co-creation in service ecosystems.
Talent development practices and processes in learning organisations: evidence from South African higher education institutions
Authors: Abiwu Lawrence , Martins Isabel
Published: July 2023

Purpose

The purpose of this paper was to identify talent development practices and processes that enhance professional and career growth of employees in South African higher education institutions (HEIs).

Design/methodology/approach

A quantitative study was carried out to investigate the subject matter. A structured questionnaire was used to collect the data from 265 academics in three South African HEIs. The Statistical Package for the Social Sciences, version 27.0, was used to analyse the data. Cronbach’s alpha coefficient and factor analysis were used to test the reliability and validity of the measuring instrument. Pearson’s correlations and regression analysis were used to interpret the relationship between the independent and dependent variables.

Findings

The results of the Pearson correlation test established a strong positive influence of training development, coaching and mentoring and career development on talent development. On the other hand, linear regression results indicated that training and development, coaching and mentoring and career development made a strong contribution to the model.

Research limitations/implications

The scope of the study only applied to South African HEIs, making the generalisation of the findings to be limited because of the differences in an organisational context. Hence, future research should focus on different industries.

Practical implications

The study contributes to understanding how talent development can be leveraged to assist academics in HEIs to improve their professional and career goals. The findings suggest that HEIs must invest in talent development to help academics acquire the skills, knowledge and competencies required to perform their tasks.

Originality/value

This paper sheds more light on talent development practices and processes that enhance academic skills, knowledge and competencies in HEIs. Moreover, the study expands on the findings of prior studies concerning talent development in learning organisations.
Water quality impacts of climate change, land use, and population growth in the Chesapeake Bay watershed
Authors: Bhatt Gopal , Linker Lewis , Shenk Gary , Bertani Isabella , Tian Richard , Rigelman Jessica , Hinson Kyle , Claggett Peter
Published: July 2023

The 2010 Chesapeake Bay Total Maximum Daily Load was established for the water quality and ecological restoration of the Chesapeake Bay. In 2017, the latest science, data, and modeling tools were used to develop revised Watershed Implementation Plans (WIPs). In this article, we examine the vulnerability of the Chesapeake Bay watershed to the combined pressures of climate change and growth in population, agricultural intensity, and economic activity for the 60‐year period 1995–2055. The results will be used to revise WIPs, as needed, to account for expected increases in loads. Assessing changes relative to 1995 for the years 2025, 2035, 2045, and 2055, mean annual precipitation increases of 3.11%, 4.21%, 5.34%, and 6.91%, respectively, air temperature increases of 1.12, 1.45, 1.84, and 2.12°C, respectively, and potential evapotranspiration increases of 3.36%, 4.43%, 5.54%, and 6.35%, respectively, are projected. Population in the watershed is expected to grow by 3.5 million between 2025 and 2055. Watershed model results show incremental increases in streamflow (2.3%–6.2%), nitrogen (2.6%–10.8%), phosphorus (4.5%–26.7%), and sediment (3.8%–18.8%) loads to the tidal Bay due to climate change. Growth in population, agricultural intensity, development, and economic activity resulted in relatively smaller increases in loads compared to climate change.
Predicting irreducible water saturation of unconventional reservoirs by using NMR T2 spectra: Methods of morphological division and fractal models
Authors: Junjian Zhang , Guo Yuqiang, , Qin Zhenyuan , Chongtao Wei , Qinhong Hu , Vandeginste Veerle , Heyao Miao , Peng Yao , Pengfei Zhang
Published: July 2023

Irreducible water saturation restricts an efficient petroleum drainage in unconventional reservoirs. T2 cutoff value identification by using NMR T2 spectrum is the key to clarifying irreducible water saturation. In this paper, saturation and centrifugal T2 spectra of sandstone and coal samples were carried out to calculate T2 cutoff value, with methods of single fractal dimension, multi‐fractal dimension, and spectrum morphological discrimination; In addition, the applicability of these three methods in characterizing T2 cutoff was discussed. The parameters related to T2 cutoff can be divided into two types: (1) The first type is morphological parameters including main peak position ™ and smaller pore volume percentage (SPVP); with an increase of T2 cutoff, TM increases linearly and SPVP decreases exponentially, and the correlation between SPVP and T2 cutoff is stronger than that of TM; (2) Second type is fractal parameters of D2 (larger pore), D−10‐ D10 and D−10/D10; with the increase of T2 cutoff, all single and multi‐fractal dimensions increase linearly, and correlation between D2 and T2 cutoff is stronger than that of multi‐fractal dimension. When calculating the T2cutoff of samples with developed macro‐pores, spectrum morphological methods should be preferentially used, while the fractal dimension discrimination methods need to be used for T2cutoff of samples with developed micro‐pores.
The use of quality improvement interventions in reducing rarely appropriate echocardiograms: A systematic review and meta‐analysis
Authors: Tao Michael , Al‐Sadawi Mohammed , Ahmed Navid , Dianati‐Maleki Neda , Mann Noelle , Kort Smadar
Published: July 2023

Background

The volume of cardiac imaging continues to increase, with many tests performed for rarely appropriate indications. Appropriate use criteria (AUC) documents were published by the American Society of Echocardiography and American College of Cardiology, with quality improvement (QI) interventions developed in various institutions. However, the effectiveness of these interventions has not been assessed in a systematic fashion.

Methods

We searched Ovid MEDLINE, EMBASE, Scopus, Web of Science, Google Scholar, and EBSCO CINAHL for studies reporting association between cardiac imaging, AUC and QI. The search was not restricted to time or publication status. We selected studies assessing the effect of QI interventions on performance of rarely appropriate echocardiograms. The primary endpoint was reduction of rarely appropriate testing.

Results

Nine studies with 22,070 patients met inclusion criteria. Mean follow up was 15 months (1–60 months). QI interventions resulted in statistically significant reduction in rarely appropriate tests (OR 0.52, 95% CI: .41–.66; p < .01). The effects of QI interventions were analyzed over both the short (<3 months) and long‐term (>3 months) post intervention (OR 0.62, 95% CI: .49–.79; p < .01 in the short term, and OR 0.47, 95% CI: .35–.62; p < .01 in the long term). Subgroup analysis of the type of intervention, classified as education tools or decision support tools showed both significantly reduced rarely appropriate testing (OR 0.54, 95% CI: .41–.73; p < .01; OR .47, 95% CI: .36–.61; p < .01). Adding a feedback tool did not change the effect compared to not using a feedback tool (OR 0.49 vs. 0.57, 95% CI: .36–.68 vs. 39–.84; p > .05).

Conclusion

QI interventions are associated with a significant reduction in performance of rarely appropriate echocardiography testing, the effects of which persist over time. Both education and decision support tools were effective, while adding feedback tools did not result in further reduction of ordering rarely appropriate studies.
A systematic review of economic evaluations of interventions targeting childhood overweight and obesity
Authors: Onyimadu Olu , Violato Mara , Astbury Nerys M. , Hüls Hannah , Heath Laura , Shipley Alexandra , Taylor Harriet , Wilkins Laura E. , Abhari Roxanna E. , Jebb Susan A. , Petrou Stavros
Published: July 2023

This systematic review critically appraised and synthesized evidence from economic evaluations of interventions targeting childhood excess weight. We conducted systematic searches in 11 databases from inception to April 19, 2023. Studies were eligible if they evaluated interventions targeting children up to 18 years and the study intervention(s) targeted childhood excess weight or sought to improve diet or physical activity, regardless of the type of economic evaluation or the underpinning study design. We synthesized evidence using narrative synthesis methods. One‐hundred fifty‐one studies met the eligibility criteria and were classified into three groups based on the intervention approach: prevention‐only (13 studies), prevention and treatment (100 studies), and treatment‐only (38 studies). The predominant setting and study design differed considerably between the three groups of studies. However, compared with usual care, most interventions were deemed cost‐effective. The study participants' ages, sex, and socioeconomic status were crucial to intervention cost‐effectiveness. Interventions whose effects were projected beyond childhood, such as bariatric surgery, lower protein infant formula, and home‐based general practitioner consultations, tended to be cost‐effective. However, cost‐effectiveness was sensitive to the assumptions underlying the persistence and intensity of such effects. Our findings can inform future recommendations on the conduct of economic evaluations of interventions targeting childhood overweight and obesity, as well as practice and policy recommendations.
Predictors of post‐stroke depression: the perspective from the social convoy model
Authors: Wang Bin , Ding Xing‐xing , Zhang Heng , Liu Zhi‐min , Duan Pei‐bei , Dong Yin‐feng
Published: July 2023

Background

Post‐stroke depression (PSD) as one of the most common neuropsychiatric disorders after a stroke and is caused by many factors. However, the relationships among different factors and their potential contributions to PSD remain unclear.

Methods

Two hundred and seventy‐six patients were recruited into this study. The general information questionnaire, the Patient Health Questionnaire‐9, the Perceived Social Support Scale, the Family Assessment Device, the General Well‐Being Scale, the Barthel Index, and the modified Rankin Scale were used to assess the condition of patients. Subsequently, we identify the main causes associated with the PSD and then performed a path analysis to clarify the direct, indirect and total effects among the variables.

Results

We found that age, stroke with coronary heart disease, neurological function, family function, social support, and general well‐being had a significant impact on PSD (P < 0.05). Of these, neurological function had the largest total effect on PSD (β = 0.451), social support contributed the most as a direct effect (β = −0.306), and family function showed the largest indirect effect (β = −0.264).

Conclusion

Individual, disease, and social‐psychological factors all contributed to the development of PSD. We should pay more attention to comprehensive assessment, especially for those with poor neurological function, and lacking family or social support. In addition, it would be preferable to provide them with necessary support and care strategies to reduce the incidence of PSD.
Globalising positivity discourses and women
Authors: McDonald Matthew , Nguyen Lan Thi , Nguyen Thao Thi Thu , Tran‐Kieu Nhu Quynh , Do Hien Thi‐Thu
Published: July 2023

Positivity discourses targeting women have become a global phenomenon. A body of literature has responded to criticise their potential to psychologise and depoliticise efforts to achieve gender equality. The purpose of this review is to analyse this critiques' literature, which mostly focuses on the Western context, to better understand the phenomenon and how its analysis might be applied to a non‐Western context, in this case Vietnam. As a group of scholars based in Vietnam, we have observed a similar set of positivity discourses emerge in the country over the last 10 years. Despite its grounding in a Western context, we argue that the critique's literature and its theoretical interpretations, when situated differences are considered, are useful for analysing the emergence of this phenomenon in Vietnam. The review provides insights for social psychologists wishing to engage with questions on women's subjectivity in a global context.
Difficulties, uncertainty, and opportunity: The experience of the COVID‐19 pandemic by early to late adolescence in the Czech Republic
Authors: Štěpánková Lenka , Fikrlová Jana , Albrecht Andrea , Šerek Jan , Brojáč Jakub
Published: July 2023

The pandemic created an unfamiliar situation for adolescents, especially within the school context. Drawing on the theory of cognitive appraisal, according to which people evaluate the benefit, harm, and threat of a certain event, this study explored Czech adolescents' experiences of the COVID‐19 pandemic. We conducted six focus groups with early (11–12 years), middle (14–15 years), and late (18–19 years) adolescents. Using thematic analysis, we identified three themes—pandemic as difficulties, uncertainty, and a (un)seized opportunity. While some younger participants initially perceived the pandemic as exciting, others struggled immediately with isolation, online learning, and disrupted daily activities. The feelings of distressing uncertainty, but also the appraisal of the pandemic as an opportunity to utilize free time differently, which in some cases faded over time, prevailed among late adolescents. This study captured the effects of the pandemic and its appraisals on adolescents' subjective well‐being and the shift in the thinking of early and late adolescents.
Supplemental Material: Development of a back-arc basin from initial rifting to seafloor spreading: Constraints from Paleozoic basic rocks in the North Qinling accretionary orogen, central China
Authors: Chang Huan , Wu Yuan-Bao , al. et
Published: July 2023

Figures S1–S6. Table S1: Zircon U-Pb isotopic data obtained by SIMS for samples 16QL87 and 16QL89 from the mafic dikes of the Qinling orogen. Table S2: Major (in wt%) and trace element (in ppm) contents of the mafic dike samples and international and Chinese standards. Table S3: Whole-rock Sr-Nd-Hf isotope compositions of the mafic dike samples (t = 453 Ma). Table S4: Zircon Hf and O isotopic data obtained by LA-MC-ICPMS and SIMS for samples 16QL87 and 16QL89, respectively. 
Report of 2021 DINRG Workshop on Centralization in the Internet
Authors: Huitema Christian , Huston Geoff , Kutscher Dirk , Zhang Lixia
Published: July 2023

The Internet Research Task Force (IRTF) Research Group on Decentralizing the Internet (DINRG) hosted a workshop on
Centralization in the Internet
on June 3, 2021. The workshop focused on painting a broad-brush landscape of the Internet centralization problem space: its starting point, its driving force, together with an articulation on what can and should be done.