bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study to Assess Women’s Autonomy in Household Decision Making Under Field Areas of Medical College Health Unit, Pangappara
Authors: U S Suneesha , T S Priya , S S Mini
Published: July 2024

Background: Women play a central role as the primary caregivers for both children and the elderly, globally. Indian culture attaches great importance to women, who comprise the half of world’s population. In sustainable development, goal 5 advocates gender equality and women empowerment. When women empowerment is hindered, they lack the ability to make choices regarding their own health care, education and career, they are restricted from moving freely without family permission, leading to a state of neglect and dependency.
Aim: The aim of this study was to assess Women’s autonomy in household decision making under field areas of Medical College Health Unit, Pangappara, Thiruvananthapuram and the secondary objective was to find out the factors associated with women’s autonomy in household decision making.
Methodology: The design adopted for the study was cross sectional survey. The study was conducted in a community setting. The data was collected from 330 women who met the eligibility criteria and they were selected by cluster sampling method. Data collected includes socio demographic data of women and women’s autonomy was assessed using Women’s autonomy Measurement scale.
Results: The result showed that 31.8% of women had poor autonomy, 6.1% of women had average autonomy and 62.1% of women had good autonomy in household decision making. The factors associated with women’s autonomy were age, marital status, independence in handling financial matters, living pattern and involvement in monthly household expenditure preparation. This study concludes that women’s autonomy in Kerala is better than other states of India.

Keywords: Women’s autonomy, Household decision making, Married women
Visitors Perceptions of Environmental Conditions in the Siring Tendean Tourism Area in Banjarmasin City
Authors: Putri Wulandari Romadhini , Sri Mahreda Emmy , Lilimantik Emmy
Published: July 2024

This research analyzes environmental conditions in the Siring Tendean Tourism Area based on visitor perceptions. Siring Tendean, one of the popular tourist destinations in Banjarmasin City, needs help maintaining ecological quality due to the increasing number of visitors. Using qualitative methods and data collection techniques through surveys and literature studies, this research involved 97 randomly selected respondents. The research results show that visitors' perceptions of tree sustainability and air cleanliness are classified as good, while perceptions regarding the availability of clean water and waste management are in the medium category. Hopefully, these findings can become a reference for managers and local governments in formulating more effective and sustainable environmental management policies in the Siring Tendean Tourism Area.

Keywords: environmental conditions, perceptions, visitors, Siring Tendean
Testing the Efficacy of a New Intervention Against Stress and Psychosomatic Symptoms
Authors: Pilafas Georgios , Louka Penelope , Lyrakos Georgios
Published: July 2024

The present study is conducted with a view to providing the first evidence in support of a new cognitive behavioral intervention that was designed to decrease several stress-related mental and somatic symptoms of health professionals during the COVID-19 pandemic in Greece, as well as to increase resilience and self-efficacy. The study is a randomized-control trial, and Factorial (2*3) Mixed ANOVAs were employed to present the effect of the intervention on 6 variables (psychosomatics, stress, anxiety, depression, resilience and self-efficacy) over time (as baseline [T1], post-intervention [T2] and 3-month follow-up [T3]). The intervention was delivered by two different instructors. 48 Greek health professionals (Mage= 36.1, SD= 12.66) were randomly allocated in two groups, as one group received the intervention (Nexperimental= 25), while the other nothing (Nnon-experimental= 20) with no great loses for both groups. All variables were measured through self-reported tools including PSSQ-29 (psychosomatics), the Greek versions of DASS-21 (stress, anxiety and depression), NMRQ (resilience) and GSE (self-efficacy). The results show that the intervention group showed significant differences in all DVs between T1 and T2 as well as between T1 and T2, while there were no differences between T2 and T3. The results of the present study are limited, but still promising for the efficiency and efficacy of the new intervention. The study took place through the spread of COVID-19 in Greece and thus new studies may test the intervention on other conditions.

Keywords: Psychosomatic symptoms; Stress management; COVID-19; randomized-control trial; RCT
The Role of Islamic Advertising Ethics and Word of Mouth in Building Brand Awareness of Indonesian Islamic Bank Customers
Authors: Hendrajati Danang , Muljono Pudji , Syarief Hidayatullah Furqon
Published: July 2024

The growth of sharia banking in Indonesia over the last four years continues to show a positive trend, in the 2023 report the Financial Services Authority stated that the market share growth of sharia banking in Indonesia was 10.9 percent of national banking. However, sharia banking has a problem where financial literacy in sharia banking in Indonesia is only 8.9 percent, while conventional banking is at 37.7 percent. The aim of this research is to find out the role of Islamic advertising ethics and word of mouth in building brand awareness. This research uses the SEM analysis method in processing data. The sample selection technique in this research used non-probability sampling with purposive sampling technique. The respondents in this research were 100 people who were customers of Indonesian sharia banks. The results of this research show that Islamic advertising ethics and word of mouth have a positive and significant effect on brand awareness.

Keywords: brand awareness, Islamic advertising ethics, word of mouth
Impact of Corporate Governance on Financial Performance: A Study of Deposit Money Banks in Nigeria
Authors: Udoka Helen Chukwu , Sabastine Nwali Ogbonna , Godson Okoro Ogbuagu,
Published: July 2024

The study examined the impact of corporate governance on financial performance in deposit money banks in Nigeria. The specific objectives were to: assess the impact of board size, board composition and number of board meeting on profit for the year in deposit money banks in Nigeria. The research design was quantitative research design. The population for this study consists of all the twenty (20) deposit money banks in Nigeria as at February, 2016. The timeframe considered for this study is 2015 to 2022, which covers a period of eight (8) years. The simple random sampling by slip of paper without replacement was used to select four deposit money banks in Nigeria namely Access Bank, First Bank of Nigeria Plc, UBA Plc, and Zenith bank. The secondary data were sourced from annual report of quoted banks in Nigeria. The data analytical techniques descriptive statistics, correlation matrix and Generalized Panel Ordinary Least Squares (GLS). The empirical results show that board size has positive and significant impact on financial performance in deposit money banks in Nigeria (t-statistic; 2.9267; P-value; 0.0043 < Sig-value; 0.05); board composition (BC) has positive and significant relationship with profit for the year (PY) in deposit money banks in Nigeria (t-statistic; 2.9267; P-value; 0.0043 < Sig-value; 0.05) and board number of meeting (BM) has positive and insignificant impact on profit for the year (PY) in deposit money banks in Nigeria (t-statistic; 0.8079; P-value; 0.4212 > Sig-value; 0.05). The study recommended that Management of deposit of money banks should ensure that good corporate governance practice should not be regarded as a threat to entrepreneurial drive and spirit but a gauge to promoting integrity and transparency in financial reports.

Keywords: Board Size, Board Composition; Number of Board Meeting
POST-PANDEMIC SURVEY OF BUSH MEAT TRADE AND EX-SITU CONSERVATION PRACTICES: A CASE STUDY OF EPE WILDLIFE MARKET AND ZOOS IN LAGOS, NIGERIA.
Authors: Ebelechukwu F. C. , Akeredolu E. O. , Asekun F. O.
Published: July 2024

The post-COVID-19 era has profoundly impacted zoos and wildlife markets, prompting the implementation of new measures to prepare for future pandemics. This study examines the responses of zoos and bushmeat markets in Lagos State, Nigeria, to pandemic challenges and assesses the effectiveness of their post-pandemic strategies. Research was conducted at three sites in Lagos; Shodex Zoo Garden, Omu Resort Zoo, and Epe Wildlife Market, a hub for bushmeat trade. Data were collected using 150 semi-quantitative questionnaires distributed among bushmeat traders and zoo staff: 50 at Epe Wildlife Market and 100 among zoo staff and visitors at the two zoos. The survey evaluated the impact of the pandemic on animal welfare, zoo operations, and the bushmeat trade. Before the pandemic, zoo animals were in excellent condition, but during the pandemic, their condition deteriorated due to reduced food supplies, medical care, and veterinary services. Zoos suspended visitor access, enhanced hygiene protocols, and made dietary adjustments, but veterinary care was insufficient. Seventy-two percent of zoo staff reported increased illness among animals, primarily due to loneliness and depression. Post-pandemic, the effectiveness of these measures varied. Visitor behavior changed little, with 64% of respondents reporting no significant change in visitation frequency. The bushmeat trade faced significant disruptions due to movement restrictions and decreased demand but rebounded post-pandemic, returning to pre-pandemic levels. The study highlights the need for zoos to adopt more robust practices for future pandemics. The Study recommends  improving zoo conditions, promoting sustainable ecotourism, enforcing stricter bushmeat trade regulations, increasing public education, and supporting alternative livelihoods to reduce reliance on illegal wildlife trade. Collaborative efforts among conservationists, governments, and local communities are crucial for effective wildlife protection.
Polymorphism of the TLR3 gene in Predisposition to Chronic Viral Hepatitis B and C in the population of Turkic-speaking peoples
Authors: Nurlanova Gulzhanat , Iskakova Aigerim , Astrakhanov Akezhan , Amanzhanova Aigul , Zhumagaliyeva Galina
Published: July 2024

Background: Over the past four years, more than 19000 cases of viral hepatitis B have been registered in Kazakhstan. Mortality from liver cirrhosis as a result of chronic hepatitis B and C ranks first among gastroenterological diseases in the Republic. Toll-like receptor 3 (TLR3) is an effector of innate immune responses and plays a key role in the body's antiviral defense. The purpose of this paper is to analyze the latest scientific data regarding TLR3 polymorphism variants in Turkic-speaking countries and their influence on the predisposition and course of chronic hepatitis B and C. Materials and Methods: To achieve the goal, relevant papers over the past 5 years in scientific medical publications on academic search platforms were selected and processed. Results: The paper analyzes variants of TLR3 polymorphisms in terms of their involvement and predisposition to the development of viral hepatitis among Turkic-speaking peoples. It has been established that the Phe/Leu substitution is associated with a decrease in the activity of adaptive immunity reactions and hyperproduction of interleukins; TLR3 single nucleotide polymorphisms of the rs5743305 (T/A) and rs3775291 species among Turkic-speaking peoples do not affect the nature of progressed viral hepatitis B and C. The rs13126816 variant is associated with a predisposition to infection and the active course of the chronic form of hepatitis C. The G-allele rs13126816 TLR3 is associated with a high probability spontaneous clearance of hepatitis C. The TLR3 single nucleotide polymorphism rs3775291 may be associated with pathological immune responses during the primary development of viral hepatitis B. Conclusion: Thus, the study of the presence of TLR3 polymorphisms in patients of Turkic-speaking countries with viral hepatitis B and C, or in groups of patients with an increased risk of infection, affects the understanding peculiarities of antiviral protection in mutation carriers, the intensity of innate immunity reactions, as well as enables predicting the nature of the course of a chronic process and the risk of developing terminal complications.
Development and Validation of a Stability Indicating RP-HPLC Method for the Estimation of Deferiprone in its Capsule Dosage Form
Authors: S Fegade Bharti , S. Mhatre Aishwarya , K. Munipalli Vijay , P Magar Hemant , P Thakur Pankaj , Kumar Ashok , Bhaskar Vaidun
Published: July 2024

A simple, precise, new stability indicating RP-HPLC method was developed and validated for the determination of deferiprone in its solid pharmaceutical dosage form. The reverse phase high performance liquid chromatography (RP-HPLC) was used for the quantitative determination of deferiprone using UV/VIS detector. The chromatographic separation was carried out on Zorbax SB C18 column (4.6*250 mm,5 um) with a mobile phase of methanol-buffer (25mM Potassium dihydrogen phosphate and 1ml TEA in 1000 ml at (PH 3.5)) in the (40:60% v/v) ratio. The detection wavelength was found to be 280nm with a flow rate 0.6 ml/min and temperature of 40°C.The retention time of deferiprone was found to be 4.7 min. The developed method was validated in accordance with ICH guidelines (ICH Q2 R1). The calibration curve was found to be linear over the concentration range of 10-150µg/ml and shows correlation coefficient (r2) of 0.999. Deferiprone was found to have LOD and LOQ values of 3.3ug/ml and 10.1ug/ml, respectively. The percent recovery of deferiprone was found to be within limit.The method was found to be robust even by change in flow rate, temperature, and wavelength. The developed method can be successfully employed in a routine analysis of deferiprone in pharmaceutical dosage form. Force degradation studies were also carried out by exposing the deferiprone samples in a various stress condition such as acidic, alkaline, hydrolytic, oxidative, thermal, photolytic degradation to establish the specificity of method.
Antioxidant activity of Methanol extracts and the Isolation of new compounds from Senggugu’s root bark (Clerodendrum serratum L.Moon)
Authors: Nasrudin Nasrudin , Wahyono Wahyono , Mustofa Mustofa , Asmah Susidarti Ratna
Published: July 2024

Senggugu is reported to contain potent antioxidant compounds. This study aims to determine the antioxidant activity, to isolate and to characterize the structure of antioxidant compounds of methanolic extract of senggugu’s root bark. The ground dried root bark was macerated gradually with n-hexane, ethyl acetate and methanol. The methanol extract was evaluated for the antioxidant activity using DPPH radical scavenging method and its antioxidant activity was compared to rutin (positive control). Isolation of the antioxidant compound was performed using preparative thin layer chromatography over silica gel GF254 eluted with a mixture of ethyl acetate: acetone: formic acid: water (5:3:1:1). The active compound was obtained as needle like crystals and the structure was characterized by spectroscopic methods as kojic acid which has never been reported as a constituent of this plant. Methanol extract showed to have DPPH scavenger activity with the IC50 12.63±0.09μg/mL, weaker than rutin (IC50=3.49±0.006μg/mL). Kojic Acid is a new compound from the methanol extract of senggugu’s root bark which has very strong antioxidant activity.
Evaluation of Biological Activity of Pomegranate Peel Extract as Antioxidant, Antimicrobial and Anticancer
Authors: Samir Abd Elzaher Mohamed Ahmed , El-Kholany E. A. , M. Bakr Yasser , S. Khattab Essam , Ghazy Mohamed B.
Published: July 2024

Pomegranate peel contains a significant quantity of antioxidants, phenols, and flavonoids, which have been shown to have strong anticancer properties. These substances also show potential in treating chronic diseases like stomach ulcers, skin, prostate, colon, and breast cancers. This work aims to evaluate the phytochemical composition of aqueous and ethanolic extracts derived from pomegranate peel and investigate their potential antibacterial and anticancer properties. In comparison with the aqueous extracts, the phenolic and flavonoid components of the pomegranate peel ethanolic extracts showed higher significant levels. Furthermore, ethanolic extracts have demonstrated a stronger antioxidant action. Hesperidin was found to be the main flavonoid compound, while pyrogallol was shown to be the major phenolic compound. When comparing these compounds to the aqueous extract and raw material, the ethanolic extract showed the highest values. Pomegranate peel extract, especially the ethanolic extract, has potent antibacterial and antifungal effects against pathogenic microorganisms. The ethanolic extract demonstrates greater efficacy than the aqueous extract and commercial antibiotics, mainly attributed to its higher polarity and better extraction capacity for active compounds such as phenolic and flavonoid compounds. Pomegranate peel aqueous and ethanolic extract effectively and safely inhibit cell proliferation of liver and colon tumour cells. Pomegranate peel polyphenols cause chemo-prevention and selective toxicity against cancer cells. Both aqueous and ethanolic extracts promote tumour cell apoptosis and necrosis. Notably, the ethanolic extract has more induction of apoptotic and reduction of necrotic cells than the aqueous extract.
Therapeutic Potentials of Persimmon (Diospyros kaki): An Updated Review
Authors: Sharma Mrinal , Goyal Pradeep , Mittal Payal
Published: July 2024

Persimmon (Diospyros kaki) also known as Japani phal belongs to family Ebenaceae. It is well known for its nutritional qualities and possess antioxidant, antibacterial, anticancer etc. Intake of the persimmon is of great interest because several research were done that have associated its consumption with health benefits. It's high in vitamin A, ascorbic acid, calcium, potassium, antioxidant phenolic compounds, and other tannins, and its fruits and leaves have traditionally been used to cure dyspnea, paralysis, bleeding, cough, hypertension, frostbite, and burns. The pharmacological activities of the plant are due the presence of bioactive compounds /phytochemicals. Tannins have anti-mutagenic, anti-carcinogenic activity, and pro anthacyanidin aids in the treatment of hyperlipidemia and hyperglycemia. Carotenoids are important for quenching free radicals, reducing risks associated with cardiovascular variables and DM (diabetic mellitus). Owing rich phytochemistry and effectiveness in mitigating oxidative damage induced by reactive oxygen species. Number of plants were studied for their chemical constituent’s importance in allopathic field. The plant has many beneficial uses already those benefits discussed in this review article for the future references. Persimmon unique characteristic is high soluble tannin content, that is mainly responsible for its astringent activity. Persimmon is generally classified into astringent and non-astringent types. Current scientific data confirmed the medicinal values of Persimmon.
T lymphocyte cell epitopes prediction of newcastle disease virus isolated from pigeon (Columba livia domestica)
Authors: Rahmahani Jola , Abdul Rantam Fedik , Regilya Fatimah Tetri , Hanny Irawan Anastasia , Putri Naimah , Hendrianto Eryk
Published: July 2024

Newcastle disease is a viral disease that occurs annually in poultry farms in Indonesia. It is caused by infection of avian paramyxovirus serotype 1. It infects many types of birds, including pigeons, ostriches, waterfowl, chickens and parrots. Controls such as vaccination, did not protect poultry from infection with Newcastle disease virus (NDV). It should be noted that the protective efficacy of seed vaccines is affected by epitopes that produce different levels of protective efficacy in vaccination regimens. Subunit vaccines might be the best choice for preventing NDV infection. Pigeon (Columba livia Domestica) samples were collected at a live bird market in Surabaya. Collected samples showed clinical signs such as respiratory distress, limp, anorexia, and subclinical bowel/diarrhea. A molecular approach was taken to obtain the nucleotide sequences of the samples. Molecular analysis was performed to obtain B-cell epitopes that can safely induce the immune system. This sequence was used for T lymphocyte cell epitope analysis using EIDB. The obtained epitopes were analyzed with Vaxijen, Allertop and ToxinPred and confirmed to be safe to use. Peptides were obtained from her NDV-infected pigeons identified as potential seed vaccine candidates. Some peptides such as GSWVYIHLLSTFTLL, PYMVVRLRRSLNTCKL, NWQLSLRPYMVVRLR, RASLANLYPAAFSVF were obtained from Pigeon/Surabaya/2019/03, while Pigeon/Surabaya/2019/01 produced some peptides, but the required characteristics did not meet. These epitopes may be used as subunit vaccines to eradicate Newcastle disease virus.
Comparing Intraperitoneal Adhesion by various Lipid compounds in a Rat Model
Authors: Bilal Hakim , Muniandy Subramaniam , Sekar Mahendran , Khoon Wong Seak , Firdous Jannathul , Sugathan Sandheep
Published: July 2024

Peritoneal adhesion is a common post-surgical complication, and various methods have been investigated in order to reduce its occurrence. Aim of this study was to explore some of the locally available substances as possible anti peritoneal adhesion agents using mouse model. A total of 32 male Sprague Dawley rats were randomly devided into five groups (control group, auto-cross-linked polysaccharide hyaluronan-based gel rice bran oil, sea cucumber water and fish oil) and the tested agents were introduced into the peritoneum, following laparotomy and the creation of defect was made on left paracolic gutter to facilitate adhesion formation. Fourteen days later the rats were re-operated and the grades of adhesions were recorded. Least adhesion score was noted in group treated with sea cucumber and the test groups treated with rice bran oil and fish oil had the worst adhesion score when compared to the control. Sea cucumber was observed to have the least adhesion score, which could be attributed to its strong healing properties. Rice bran oil and fish oil were found to have the worst adhesion score, indicating that they may have potential to induce adhesion when applied externally. This study provides insight into the various methods that can be used to reduce the formation of peritoneal adhesions. The use of these substances as anti-adhesion agents presents an innovative perspective in the ongoing efforts to mitigate post-surgical complications.
Evaluation of Mechanical properties of glass ionomer cement incorporated with L-Arginine nanoparticles: An in vitro Study
Authors: Tanuja Danaboyina , Rao D. Bheemalingeswara , Alla Rama Krishna , Manikyamba Y. , Sajjan MC. Suresh , Dhanasri M.
Published: July 2024

This study evaluated the mechanical properties of glass ionomer cement (GIC) incorporated with different concentrations (0.5%, 1.0%, 2.0%, 5.0% by wt.) of L-Arginine nanoparticles. GIC powder was mixed with various concentrations of L-Arginine and mixed with its corresponding polyacrylic acid and a total of 150 specimens were made. The specimens were divided into 3 groups for evaluating compressive strength, shear bond strength and microhardness, with 50 in each. The fifty specimens from each group were further divided into 5 subgroups with 10(n=10) in each, based on the concentrations of nanoparticles. The shear bond strength samples were tested on the universal testing machine, The load was applied at a crosshead speed of 0.5 mm/minute until the specimen was debonded from the tooth. Compressive strength the sample was placed on the compression grip of the universal testing machine and the load was applied at a crosshead speed of 0.5 mm per minute until the specimen fractured. The microhardness of the specimen was measured using the Vickers Hardness Tester. The data obtained were subjected to statistical analysis using one-way ANOVA and Tukey’s test. GIC modified with 0.5% L-Arginine demonstrated high Shear bond strength (6.76±0.89 MPa), Compressive strength (117.11±24.8 MPa), and Vickers hardness (67.46±4.51VHN) compared to the other modified and control groups. One-way ANOVA showed significant differences (p<0.001) in SBS, CS, and SH among the groups. The addition of 0.5wt% L-Arginine into glass ionomer cement demonstrated an increase in the shear bond strength, compressive strength, and Vickers hardness.
Optic Neuritis in Chronic Myeloid Leukemia: A Rare Case Report in Surabaya, Indonesia
Authors: Hartanto Kurniawan Alvin , Hajat Arifoel , Budiono Notopuro Paulus
Published: July 2024

Introduction: Chronic Myeloid Leukemia (CML) is a type of myeloproliferative neoplasm in which granulocytes are the primary proliferating cells. Unilateral optic neuritis is another very rare complication of CML, with eye symptoms only consisting of 5% of CML patients. Additionally, optic neuritis in the population aged more than 50 years old is not prevalent and often manifests bilaterally. Case: A 65-year-old female presented with the main complaint of blurred right vision without any prior disease. The ocular examination revealed deteriorated visual acuity in both eyes. Ishihara test yielded 0/38 on the right eye. Complete blood count showed leukocytes 57,57 x 103/uL, hemoglobin 12,4 g/dL, and platelet 344 x 103/uL. Bone marrow aspiration showed hyperplasia of erythropoiesis, megakaryopoiesis, and granulopoiesis lineage with myeloblasts at 13%, concluded as an accelerated phase of CML. A qualitative study of chromosomal breakpoints p210 BCR-ABL was positive. Optical coherence tomography presented a thickening macula on the right ocular. Perimetry with the Humphreys test yielded scotoma in the right eye. Magnetic Resonance Imaging suggested a T2 patchy hyperintensity on both optic nerves. The visual acuity and color blindness resolved after three weeks of Imatinib treatment. Discussion: Optic neuritis is one of the rare complications in CML cases. The main mechanisms underlying visual disturbance in CML are hyperleukocytosis, leukemic cell infiltration, or therapy related, while the other possibility related to optic neuritis must be excluded. CML-related visual disturbance is diagnosed with increased leukocytes, myeloblasts in peripheral blood and bone marrow smear, abnormal visual function examination, and neuroimaging. Determining the underlying mechanism that led to optic neuritis is necessary to establish the treatment regimen. While most cases were due to hyperleukocytosis, this case was more likely due to infiltration. The patient’s vision improved after Imatinib treatment for three weeks. Conclusion: Optic neuritis, despite its rarity, could become a complication in a CML patient. An appropriate early diagnosis and treatment are necessary for a favorable outcome.
Serum SIRT1 Levels and Genetic Variants in Diabetic Nephropathy: Insights from a Cross-sectional study
Authors: D Pai , S Adiga , G Suresh , U Adiga , S Kumari , D Chaitra , TM Desy
Published: July 2024

The aim of the study was to compare sirtuin 1 serum levels in non-insulin dependent diabetics and diabetic nephropathy patients, and evaluate the pattern of polymorphism of SIRT 1 gene in these patients, and find the relation between polymorphism of SIRT1 gene and sirtuin1 serum levels in diabetic nephropathy patients and those with various stages of diabetic nephropathy. Methodology: 108 type-2 diabetic patients without complications as controls and 108 diabetic nephropathy patients as the case group were included in the study. SIRT 1 expression was measured by ELISA, and SIRT1 gene polymorphism was analyzed using the PCR-RFLP method. Results: The mean serum sirtuin 1 level were significantly lower in diabetic nephropathy patients compared to controls (p=0.000). The distribution of genotypes did not conform to Hardy-Weinberg equilibrium. The frequency of the wild-type genotype (AA) was higher in the case group, while the mutant allele (AG+GG) was more prevalent in controls. The distribution of genotypes did not conform to Hardy-Weinberg equilibrium (chi-square =7.203, p=0.027). There was no significant association observed between SIRT1 gene polymorphism and serum sirtuin 1 level in diabetic nephropathy patients(p=0.001). Additionally, no significant difference was found in serum sirtuin 1 level between different stages of diabetic nephropathy based on albuminuria testing and estimated glomerular filtration rate (eGFR)(p=0.33). Conclusion: Patients with diabetic nephropathy exhibited significantly lower serum sirtuin 1 level compared to controls, suggesting a potential role of sirtuin 1 in the pathogenesis of DN. We also conclude that serum SIRT 1 expression may be used as a diagnostic marker. The results indicate a need for further research to better understand the role of SIRT1 in diabetic nephropathy and its potential as a biomarker or therapeutic target for this condition.
Cytotoxicity Studies and Antiviral Activity of Sesbania grandiflora
Authors: Jaichand J , Sabu K K , Iyer T Vaidyanatha
Published: July 2024

Sesbania grandiflora (Linn) is a tree known for many medicinal properties, and all parts of the tree are used in folk medicine and Ayurveda, for various conditions such as diarrhoea, dysentery, smallpox and other eruptive fevers, nasal catarrh, bronchitis and pain. Antiviral activity and cytotoxicity of hexane, ethyl acetate, acetone and methanol extracts from the leaf, bark and flower of Sesbania grandiflora were studied. The leaf, bark and flower were separately extracted by solvents; Hexane, Ethyl Acetate, Acetone, and Methanol; sequentially. The extracts were analysed for their cytotoxic concentration by the MTT method, and antiviral activity against viruses, Herpes Simplex Virus type 1 (HSV 1) and Coxsackie virus B2 (Cox B2) in Vero cells, by inhibition of CPE. The quantity of viral nucleic acid produced was monitored in relation to untreated virus controls using real-time PCR. The study found significant antiviral activity for the different plant extracts, justifying its use in traditional medicine for various syndromes of viral aetiology. Apart from a previously reported antiviral activity of the methanol extract of flowers, this study reports the presence of compounds with significant antiviral activity in the acetone extract of leaf, acetone and ethyl acetate extracts of bark and ethyl acetate extract of flower as well. The acetone extract of the leaf showed antiviral activity against both HSV 1 and Cox B2 giving protection of 50% and 90% respectively (IC50 0.073 mg/ml). The bark ethyl acetate extract gave 100% and 60% protection (IC50 0.046 mg/ml); bark acetone extract gave 90% and 100% protection (IC50 0.1 & 0.052 mg/ml) against HSV 1 and Cox B2, respectively. Among the flower extracts, ethyl acetate extract gave 100% protection against HSV 1 and gave 80% protection against Cox B2 (IC50 0.2 mg/ml). The real-time PCR assay which quantifies the inhibition of viral DNA production had an excellent correlation with CPE production. All four extracts showed significant activity against HSV type 1 and Coxsackie B2 viruses with Therapeutic Indices ranging from 1:1 to 1:4, which is very promising for drug development, as the above therapeutic index is in the crude extract.
Recent Advances in Tropical Cyclone Forecasting
Authors: Swarna M
Published: July 2024

Tropical cyclones (TCs) are low-pressure weather phenomena characterized by a revolving circulation of high winds, heavy rain, and thunderstorms. TCs cause catastrophic damage if they make landfall in populated areas. Therefore, it is essential to monitor and prepare for potential disasters in the form of emergency responses or evacuations. For decades, predicting the intensity of tropical cyclones has been a challenging problem. The use of machine learning techniques to predict TCs is still challenging due to the number of parameters used for prediction and the availability of historical data. This paper highlights the techniques and parameters used to estimate TCs. This paper focuses on significant parameters such as ocean indices, sea surface temperature, and many others that have a greater impact on the formation of TCs. This paper discusses various opportunities and challenges in forecasting TCs in advance and the factors influencing the formation of TCs. The challenge is obtaining long amounts of historical data to analyse all ocean indices. Although many researchers have utilized ML techniques, the accuracy of TCs is still a more significant issue. Our survey focused on the importance of data fusion in accurately predicting TCs and their intensities.
Pembelajaran Piano Dasar untuk Lagu Rohani secara Daring bagi Anak Sekolah Minggu GKTDI Pekanbaru
Authors: Br. Panjaitan Rebekah Oktavia , Samosir Tanesya Hotris
Published: July 2024

Tujuan penelitian ini adalah untuk mengetahui dan mendeskripsikan hasil dari pembelajaran piano dasar pada lagu rohani secara daring bagi anak sekolah minggu GKTDI Pekanbaru. Jenis penelitian ini adalah kualitatif, dengan menggunakan metode action research. Teknik pengumpulan data dilakukan dengan cara observasi, wawancara dan dokumentasi. Teknik analisis data menggunakan model Miles & Huberman, yang terdiri dari reduksi data, penyajian data dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa: (1) Proses pembelajaran piano dasar secara daring terlaksana dengan baik, hanya saja terdapat kendala pada koneksi jaringan yang kurang baik, sehingga terdapat beberapa pertemuan yang mengalami sedikit gangguan; (2) Ketiga anak memiliki pemahaman dan hasil permainan piano yang berbeda-beda, baik dalam hal kemampuan membaca notasi balok, serta kestabilan tempo, ritmis dan dinamika. Sementara persamaannya adalah ketiga anak tersebut sangat antusias untuk belajar, baik selama proses pembelajaran piano berlangsung, maupun pengerjaan tugas latihan piano diluar kelas daring.
STRATEGI PEMBELAJARAN PIANO TINGKAT DASAR DALAM LAGU SEDERHANA UNTUK ANAK BERKEBUTUHAN KHUSUS DI JJ MUSIK COURSE KUPANG
Authors: Pingak Elizabeth Margareth
Published: July 2024

Adapun tujuan dari penelitian ini adalah untuk mengetahui bagaimana strategi pembelajaran piano tingkat dasar lagu sederhana yaitu lagu anak yang memiliki kebutuhan khusus di JJ Music Couse di Kota Kupang.  Jenis penelitian yang digunakan pada penelitian ini adalah penelitian kualitatif menggunakan pendekatan deskriptif. Penelitian ini bertujuan untuk mengurai stategi pembelajaran piano tingkat dasar lagu sederhana pada anak yg berkebutuhan khusus di JJ Music Cource yang terletak di Kota Kupang. Penelitian ini bersifat kualitatif karena prosedur masalah dilakukan dengan cara menggambarkan, melukiskan keadaan subjek atau objek penelitian pada saat  sekarang  berdasarkan  fakta-fakta  yang  ada  dan  berusaha  mengemukakan satu  dengan  yang  lain  di  dalam aspek – aspek yang diselidiki. Peneliti melakukan wawancara terhadap pengajar kursus tentang strategi pembelajaran piano tingkat dasar dalam lagu sederhana pada anak berkebutuhan khusus di JJ Musik Course Kupang. Wawancara dilaksanakan mengacu pada 5 indikator strategi pembelajaran, yaitu pengamatan, perencanaan, pelaksanaan, evaluasi dan tindak lanjut. Untuk anak berkebutuhan khusus dibutuhkan 4 x pertemuan sedangkan untuk anak normal bisa lebih cepat 1-2 x pertemuan sudah bisa memainkan lagu tersebut. Strategi pembelajaran piano tingkat dasar lagu sederhana yaitu lagu anak yang memiliki kebutuhan khusus di JJ Music Couse yaitu, pengajar harus sabar, hindari asumsi negatif, frustasi, kebingungan, dan tuntutan yang tinggi, step by step (selangkah demi selangkah) adalah memberikan pengajaran kepada anak berkebutuhan khusus sedikit demi sedikit, serta toleransi dan komunikasi.
PELESTARIAN ALAT MUSIK TRADISIONAL HEO MELALUI KEGIATAN EKSTRAKURIKULER DI SMP KRISTEN SION KAKUUN
Authors: KLAU JEFRIANUS
Published: July 2024

Alat musik tradisional Heo merupakan bagian tak terpisahkan dari warisan budaya yang kaya di Nusa Tenggara Timur, Indonesia. Namun, tantangan pelestariannya di era modern ini semakin meningkat akibat perubahan pola hidup dan minimnya generasi muda yang berminat mempelajarinya. Penelitian ini bertujuan untuk mengeksplorasi upaya pelestarian alat musik tradisional Heo melalui kegiatan ekstrakurikuler di SMP Kristen Sion Kakuun. Metode penelitian yang digunakan adalah studi kasus dengan pendekatan kualitatif, melibatkan pengumpulan data melalui wawancara mendalam, observasi, dan analisis dokumen terkait. Hasil penelitian menunjukkan bahwa kegiatan ekstrakurikuler di sekolah tersebut efektif dalam membangkitkan minat siswa untuk belajar dan memainkan alat musik Heo. Faktor pendukung meliputi peran guru dan komunitas lokal dalam memberikan dukungan serta sumber daya yang memadai untuk pembelajaran. Namun, tantangan utama yang dihadapi adalah kurangnya waktu yang cukup untuk praktik reguler dan pemahaman mendalam mengenai sejarah dan teknik bermain alat musik Heo. Penelitian ini memberikan wawasan yang berharga bagi upaya pelestarian budaya lokal melalui pendekatan pendidikan formal dan informal di sekolah menengah
ANALISIS BENTUK MUSIK DAN NILAI KARAKTER RELIGIUS DALAM KIDUNG JEMAAT NO. 462 “TOLONG AKU, TUHAN” KARYA HANS PULS
Authors: Lenama Hendrik , Lauhuin Sinta Martina
Published: July 2024

Music analysis is an important part of the study of music and the development of musical abilities. The author suggests that every music educator include analytical activities into every music course, especially those related to the theoretical realm. Because by exploring the potential for analyzing music, musical intellectual capacity will continue to develop. This research uses a qualitative descriptive approach, namely by describing data in the form of the musical structure and lyrics of the song KJ No. 462 "Help Me, God" by Hans Puls. This song is a song with a 4/4 time signature and consists of 8 bars and contains 4 verses. This song starts on the first beat. In congregational hymns, there is no tempo in the notation of this song, but usually this song is sung rather quickly and cheerfully or at an allegretto tempo (108-116 MM). This song is a one-part song. Based on the description of religious character values contained in Song of the Congregation No. 462 "Help Me, God", it can be concluded that this hymn by Hans Puls expresses, instills and teaches the values of the Christian faith which originate from the life and teachings of the Lord Jesus, but also contains the truth of the holy books. In this way, these songs can be an effective medium or forum for internalizing religious character values.
Performance Finance from the Perspective of Standard Financial Ratio Limits and Good Corporate Governance in Banking Sector Shares
Authors: Amirudin A. , Muchran Muchriana , Rustan R.
Published: July 2024

This research is expected to provide practical and theoretical benefits. And as a source of information about the influence of financial risk on financial performance. This research can be helpful for other researchers as material for further studies regarding issues related to the impact of financial risk on financial performance in banking companies listed on the Indonesian Stock Exchange (BEI). This research can be used as material for banking evaluations so that they can implement appropriate risk management strategies to improve banking performance. Studies referred to Laeli and Yulianto (2016) and Izdihar, Hassan, And Azlina (2017) show that good corporate governance can moderate the relationship between Non-Performing Loans and bank financial performance. Results contradict the study by Akbar and Lanjarsih (2019), which shows that good corporate governance can moderate the connection between non-non-performing loans and financial performance. This research aims to find out whether management projected risk NPL (Net et al. (Loan et al.), BOPO (Operating Costs) Against Operating Income) can affect the financial performance projected by Return on Assets (ROA). This research also aims to determine whether assessing Good Corporate Governance (GCG) can moderate management relationships risk and ROA. The data used in this research is quantitative; the data used is secondary data. The data analysis techniques used in this research are the classic assumption test, moderated regression analysis, t-test, and F test using SPSS Moderated Regression Analysis (MRA) software. The results of this study show that LDR has no effect and is negatively related to ROA. BOPO has no effect and is negatively related to ROA. NPL has no effect and is positively related to ROA. GCG Self-Assessment does not moderate NPL on ROA, with a negative relationship. GCG Self-Assessment does not moderate LDR on ROA and is positively related. GCG Self-Assessment does not moderate BOPO on ROA, with an antagonistic relationship.
The Effect of Discipline Development and Work Motivation on the Performance: Empirical Study from Civil Servants at the Spatial Planning Office Bekasi City, Indonesia
Authors: Hernandi Futri Utami , Juddy Prabowo R.M
Published: July 2024

The quality of Human Resources (HR) is a critical factor in enhancing the performance of an agency's workforce. Consequently, highly skilled HR is vital for boosting team member performance. At the Bekasi City Spatial Planning Office, it has been noted that employee performance has not yet met the established work standards. Employee performance is influenced by various factors, including the development of discipline and work motivation. This study aims to investigate the extent to which discipline and work motivation contribute to the performance of civil servants at the Bekasi City Spatial Planning Office, both individually and collectively. Utilizing a quantitative research methodology, this study surveyed 45 civil servants from the Bekasi City Spatial Planning Office through random sampling. Data collection was conducted using questionnaires, while data analysis was performed through descriptive and associative methods using SPSS version 26. The findings reveal that the development of discipline positively influences employee performance, whereas work motivation alone does not significantly impact performance. However, when discipline and work motivation are enhanced together, they significantly improve the performance of civil servants at the Bekasi City Spatial Planning Office.
Human Resource Management Strategy: Integrating Psychological Perspectives through Qualitative Description and Literature Review
Authors: Halim Ardiansyah , Susianah S. , Gunawan G. , Mansyur Abd. , Tirtawana Mery
Published: July 2024

This study explores the integration of psychological perspectives into Human Resource Management (HRM) strategy, aiming to understand its implications for organizational effectiveness. Employing a qualitative research design, the study conducts a systematic literature review to analyze existing literature relevant to the research topic. Data collection involves comprehensive search strategies using keywords related to HRM strategy, psychological perspectives, and organizational performance. Thematic analysis is employed to identify recurring patterns and themes within the literature. The findings indicate that integrating psychological perspectives into HRM strategy enhances employee motivation, engagement, and organizational performance. Psychological theories such as Maslow's hierarchy of needs, Herzberg's two-factor theory, and self-determination theory offer valuable insights into understanding employee behavior and motivation. The study highlights the importance of addressing employees' diverse psychological needs for autonomy, recognition, and meaningful work to foster a positive work environment. Furthermore, it emphasizes the role of talent development, recognition programs, and supportive leadership in enhancing organizational performance and competitiveness. The study concludes that integrating psychological perspectives into HRM strategy holds promise for promoting organizational effectiveness and employee well-being.
ANALISIS DESKRIPTIF PENERAPAN METODE TASHILI:
Authors: Putriyani Siti Nur Umdati , Rahtikawati Yayan
Published: July 2024

Descriptive analysis research of the application of the Tashili method by taking a case study at al-Bahjah Islamic boarding school urgently is that a teacher must have the right learning method for the success of students. The purpose of this study is to explain the learning and learning of tahsin Al-Qur'an using the Tashili method at al-Bahjah Islamic boarding school. This research uses qualitative methods with data processing in the form of descriptive analysis. Observation, documentation, and in-depth interviews with various sources were used to collect data. The results of this study contain two conclusions. First, the learning of tahsin Al-Qur'an with the Tashili method at al-Bahjah Islamic boarding school consists of volume 1, volume 2, volume 3, volume 4, and volume 5. Second, the implementation of tahsin Al-Qur'an with the Tashili method at al-Bahjah Islamic boarding school uses an individual approach, individual classical, pure reading and listening, and reading and imitating. With these two conclusions, the application of the Tashili method at al-Bahjah Islamic boarding school tends to emphasise the potential of students according to their respective scientific capacities in a categorised manner.
EPISTEMOLOGI ‘ILM LADUNNI PERSPEKTIF ABU HAMID AL-GHAZALI
Authors: Rohman Ahmad Yani Fathur
Published: July 2024

The purpose of this research is to explain the epistemology of Laduni Science in al-Ghazali's perspective. There are three epistemologies in Islamic science itself, including bayani, burhani, and 'irfani. Al-Ghazali's style of thought is bayani and 'irfani. Laduni science is the hallmark of al-Ghazali's scientific thought, especially from the 'irfani aspect which is reinforced through the Al-Quran and Hadith. This research uses the library research method. The result of this research is that Laduni Science according to al-Ghazali is knowledge that is directly given by Allah Swt., without intermediaries. Laduni knowledge is only given to his servants who have devotion to Allah Swt. in totality. To get Laduni Science according to al-Ghazali, first, try to achieve all knowledge and take the most rations from the most knowledge. Second, al-riyadah al-sadiqah and al-muraqabah al-sahihah, and still fear Allah Swt. truly. Third, tafakkur when the soul has learnt some knowledge. Fourth, purifying the rabb?niyyah heart which is adorned with dhikrullah.