bluuebunny/crossref_metadata_2025 huggingface dataset:
Models of project activity in the information and educational environment
Authors: Tulokhonova Inna , Gluhkova Irina
Published: November 2018

One of the priorities of the process of informatization of modern society is the informatization of education. This is the process of ensuring the education sector with the methodology and practice of development, the optimal use of modern information and communication technologies aimed at implementing the goals of state educational policy. This direction of development of the educational industry, as emphasized in government documents, is recognized as the most important national priority. At the same time, the creation of optimal conditions for the productive activities of the subjects of the educational process is a complex task, causing the design and development of the subject informational and educational environment, as an opportunity for a comprehensive and concrete solution of the training tasks and the form of organization of the effective activities of its subjects. At the same time, the existence of procedures and rules governing the joint activity of subjects and its organization is a basic feature of the system that determines the order of an activity and the mechanism of its operation. In addition to the mechanism of operation, we can distinguish the mechanism of management as a set of procedures for making management decisions. The authors of this work consider project activity as a particular task of designing the activity itself and the dynamic system of interaction of the subject with the world in general, and the realization of the mediated relations of the subject in objective reality in particular, acting on the controlled system in order to ensure the required behaviour. The article presents the results of the development of models of project activities, organizing the process of learning management in the subject information and educational environment of the university.
Color Designation in V.V. Mayakovsky’s Poetics: “Red” and “Yellow” (mythological implication)
Authors: Dudareva Marianna , Nikitina Vlada
Published: November 2018

The article deals with semantics of “red” and “yellow” color in V.V. Mayakovsky’s poetics. A lot has been written about “red” color; this color is associated with the revolutionary ideas and symbols, and it is often used in Mayakovsky’s early works. However, “yellow” color is used along with “red” one and, in our opinion, it has more complicated semantics. This color is important for the poet himself and his creative life (Mayakovsky’s yellow blouse), and for his early poems where we see the clothing elements of this color. According to folkloric ideas, it is the very color which is ambivalent; it correlates with the sun and a new life, and is attributed to mourning ritual symbolism. Folklore commentary to some details in the poems “A Cloud in Trousers”, “A Man” and “Fifth International” allows us better understanding the poet’s figurative and metaphorical system.
N. V. Gogol and E. T. A. Hoffmann: on some folklore parallels in poetics
Authors: Goeva N. P. , Dudareva M. A.
Published: November 2018

The article deals with comparative analysis of the works by N. V. Gogol and E. T. A. Hoffman. The study object is two texts: “The Night Before Christmas” by the writer from Russia and “A New Year’s Eve Adventure” by the romantic writer from Germany. The topic being analyzed is spatial models and relations thereof in the writers’ poetics. Special attention here is drawn to folklore tradition as in folk art a clear differentiation of various types of space can be observed. The parallels with Chinese fairy tales are drawn here where a literary technique of an animated portrait appeared to be relevant to the artistic world of the authors in question. Great importance is attached to archetypal structures associated with the feminine principle (the images of Oksana and Julia). Historico-literary and typological methods of the work analysis are used.
Historiosophy & Eros in Russian anacreontics
Authors: Petrov Alexej , Dubskikh Angelina , Butova Anna
Published: November 2018

“Love is the eminence grise of history”, – once one of the greats of the past said. Few doubt that history is driven by human, more or less conscious interests – economic, political, religious, etc. As for feelings, passions and instincts, their role in the historical process is not so obvious, particularly of those that are connected with policy or economy indirectly. The objective necessity to rehabilitate the position of Eros in the political life of 18th-century Russia determines the significance of the current research. The article aims to analyse how the feeling of love and/or the underpinning instincts of procreation and self-preservation affect the political life and the course of history. The most important task is to examine some of the poetic texts of the 18th – early 19th centuries, the authors of which are the part of this still non-trivial historiosophical paradigm. So, it is mainly going to be about love, but not always – about love poems. The novelty of the conducted research lies in the fact that mythological and political issues of Anacreonic poetry have already become the matter of literary criticism [1, 2], while the hidden historiosophical senses have been still neglected. Certain creative works of the 18th-century poets: M.V. Lomonosov, G.R. Derzhavin, S.S. Bobrov served as research material. The practical significance of the investigation consists in the fact that the results can be used for further studying of 18th-century literature and historiosophical problems as well as to develop special courses in historical poetry.
Tibetan Buddhism and the formation of ecological consciousness: a view from Buryatia
Authors: Bagaeva K. , Tsyrendorzhieva D. , Balchindorzhieva O. , Badmaeva M.
Published: November 2018

Technicization of human and society, active development of technogenic civilization leads to gradual separation from moral values and principles. These values include ideas of unity and harmony of human with nature, with the surrounding environment, and reasonable, moderate attitude towards natural resources. We believe that humanity should move from the industrial to ecological civilization. The foundations of a new ecophilosophy should become holistic principles, representations of philosophy in general and Buddhism in particular. We outlined basic principles and methods for improving personality of altruistic ethics of Mahayana Buddhism that contribute to human understanding of inseparability, interconnection with the world. We focus on the central Buddhist concept – the absence of an individual ‘I’ that is understood as necessity of recognizing oneself as a separate empirical individual. That is confirmed by a translation of the text PrajnaParamitaHridaya Sutra from Tibetan language. The paper analyzes three types of spiritual personality that correspond to three stages of the Path to awakening. Each stage is a step towards the formation of subjectless consciousness, that is, awareness of universal dependence and responsibility for their actions. The paper argues that for ecological consciousness it is important to form an understanding that the main reason for human existence in not the technosphere, not the economy, but the living nature.
On the issue of defining the essence of the object of the intangible cultural heritage: historical retrospective and significance for the development of modern society
Authors: Doguzhaeva Muminat , Dorokhov Nikolai , Kochemasova Tatiana , Nazarenko Natalia , Simaeva Evgeniya
Published: November 2018

The authors attempt to consider the reflection of the issues of preserving the intangible cultural heritage in the normative legal acts of the Russian Federation in different historical periods. The paper traces the state position in relation to the manifestations of the intangible cultural heritage as to the unique products of the nation with its language and history. The Purpose (the object) of the paper is the following: on the basis of analysis of historical normative material, to consider the current state and forecast possible options for the formation of Russia’s socio-cultural policy with an emphasis on the importance of the intangible cultural heritage.
Russian cultural-historical consciousness in Early Slavophile philosophy
Authors: Shirokova Marina
Published: November 2018

In this article, the author describes the concept of “cultural-historical consciousness” as substantial matter of any nation or any period in the cultural and historical development. Russian cultural-historical consciousness is considered to be the appreciation of Russian culture by its people. It is the acknowledgment of its destination and values in correlation with other cultures and the world in general. As for correlation of such concepts as “cultural-historical consciousness” and “national consciousness”, the national or ethnical principle represents one of the cultural-historical aspects. In the author’s opinion, slavophiles conceived Russian philosophy as one that truly reflects the national consciousness. They were pioneers who managed to put together the logical-conceptual tools of European science and the mindset heavily influenced by the orthodox culture, as well as included it in our national language and consciousness.
Gender Differences and Consumer Videogame Engagement
Authors: Jamak Abu Bakar Sedek A. , Abbasi Amir Zaib , Fayyaz Muhammad Shahzeb
Published: November 2018

This paper intends to examine the gender differences on the engagement states of consumer videogame engagement through comparing the male group vs. female group. To meet this objective, the authors aim to utilize the causal-comparative study to analyse the gender differences on consumer videogame engagement. Data were collected from a sample of 235 teen videogame consumers whose aged were between 16-19years and studying in the private and public universities. Out of 235, the only 219 teen videogame consumers were valid and able to further use for data analysis. Using SPSS 22.0, we examined the valid data through independent t-test and also calculated the effect size for the significant hypotheses. The study findings reported that male teen videogame consumers are significantly different from female teen videogame consumers on the three engagement states of consumer videogame engagement such as cognitive, affective, and behavioural engagement. This paper is first among the videogame studies that has investigated the gender differences on the engagement states of consumer videogame engagement.
Ethical Consumer Perceived Value in Sustaining Recycling Behaviour
Authors: Noorasikin M.M. , Ahmad Maisarah , Mashitoh Y. , Khairul Akmaliah A.
Published: November 2018

Recycling has imparted meaningful experience and perceived value from individual’s recycling activities. Consumer perceived value (CPV) is important in defining consumers’ experience that connects with one’s goals, inclinations and mental models; perceived valuable and beneficial, thus motivate sustainable behavior. This study sought to understand how ethical consumer perceived value (ECPV) influences the sustaining of recycling behavior. Nine interviews were conducted at The Federal Territory of Putrajaya for this interpretive study. It identifies two taxonomies of ethical perceived value (EPV) in individual’s sustainable recycling experience. First, ethically desirable value (EDV) taxonomy (six drivers), second, spiritual/religious value taxonomy (three drivers). This paper concludes with the value-map taxonomy of ECPV on Recycling to guide in mapping a strategic social marketing practice in Malaysia’s government policy to motivate good social conduct among individual and society.
Employer branding and employee engagement of furniture retailer in Klang Valley
Authors: Hashim Raemah Abdullah , Mohamad Nor Mohamad Azlan
Published: November 2018

The paper discussed on the relationship between employer branding and employee engagement among employees in selected furniture retailers in Malaysia. This study also looks into the state of employees’ engagement and gender differences in their engagement towards their organization. Furniture retailing falls under the retail trade industry that contributed about RM35.7 billion to Malaysia GDP in 2017 with expected growth of 8.7 percent. However, the industry suffers an average yearly employee turnover rate of 13 percent. Amid this high turnover, the raising question is can popularity of employers’ branding can result in employee engagement leading to their retention in the organisation. 350 respondents were chosen randomly and 120 (30%) respondents had given feedback on the personally administered questionnaires. The result revealed that there is significant relationship between employer branding and employee engagement. The study also indicated that work challenging is the most important variable which led to drive the employee engagement. Consequently, there is significant difference between male and female in terms of engagement. Organisation, hence may consider leveraging employee engagement which may lead to retaining their employees. Future research may consider researchers to pursue a longitudinal method of research design across a variety of firm-sizes and industries that would be more significant in making generalizations.
Impact of Situational and Dispositional Factors on Work-Family Conflict and Job Satisfaction: A Proposed Framework
Authors: Salleh Rohani , Bakar Zurina Abu , Memon Mumtaz Ali
Published: November 2018

Job satisfaction has become an empirical attention as subject of inquiry in many fields. Past studies have revealed that employees with higher level of job satisfaction mostly enjoyed their job, had higher productivity and eventually contributed to generate profit for their organization. Despite its popularity, there is still lacking in determining what exactly drives employee satisfaction from the perspective of situational and dispositional factors. Moreover, the role of mediator in is also rather limited. The present paper proposes a conceptual model from the perspective of situational factors (role overload and role conflict) and dispositional factor (core self-evaluations) to understand the concept of job satisfaction. Specifically, it is suggested that when an employee experiences either role overload, role conflict or perceive with negative core self-evaluation, one of the consequence was increased level of work-family conflict. Ultimately, individuals who perceive higher level work-family conflict will experience less job satisfaction. Recommendations for future research are also discussed.
Trustworthiness: The Core of Leadership in Islam
Authors: Alimin Nur Sofia Nabila Binti , Awang Siti Rahmah Binti , Ahmad Tahir , Safar Jima’ain , Nain Shukri Mohd
Published: November 2018

This article discusses the concept of trustworthiness as the core of Islamic leadership as well as the crucial elements in trustworthiness in instilling this concept in the present leadership. Trustworthiness can be classified into two which are for Allah and for mankind. There are four elements under the classification for Allah which are Iman, Islam, Ihsan and Taqwa. Meanwhile, under the classification for mankind, there are four elements of trustworthiness. They are just, responsibility, integrity and accountability.
How Different Ownership Structures Perform in Industry 4.0: A Case of Malaysian Manufacturing SMEs
Authors: Umrani Aamir Iqbal , Johl Satirenjit Kaur
Published: November 2018

Small and medium enterprises are vital components for economic growth globally. Similarly, the Malaysian manufacturing SMEs has contributed greatly in developing Malaysia’s economy. However, higher failure rate of the Malaysian SMEs is a great concern among researchers and government bodies. Currently, the industry 4.0 has changed the business environment globally. Therefore, this study attempts to investigate the relationship of ownership structures on firm performance with a mediating role of innovation. Baron and Kenny approach of mediation analysis was used on the sample of the Malaysian manufacturing SMEs. The results revealed that, majority SMEs prefer traditional business methods, which causes the higher failure rate in the industry.
Surgical technique for biological fixation of closed segmental tibial fractures by the Less Invasive Stabilization System (LISS)
Authors: Gamal Osama , Shams Ahmed
Published: November 2018

Introduction: This prospective case series study aimed to assess the value of the Less Invasive Stabilization System (LISS) to treat closed Segmental Tibial Fractures (STFs) using a proposed surgical technique.

Materials and methods: Between August 2010 and January 2014, 21 consecutive recently (within 1 week) closed STFs that matched the inclusion criteria were enrolled. Patients were treated with the 13-hole LISS plate. All patients were followed up every 2 weeks for the first 2 months, then every month for the rest of the first 6 months and then every 6 months thereafter. Patients were assessed radiologically during the follow-up appointments and clinically at the final visit by the Lower Extremity Functional Scale (LEFS) to evaluate the result.

Results: The mean time to union of the proximal fracture was 15.72 ± 2.78 (range: 12–20) weeks and for the distal fracture was 20 ± 2.22 (range: 16–24) weeks, excluding delayed union in three patients. All patients except the three showed radiological observable callus in a mean duration of 4.95 (range: 3–7) weeks. The mean final follow-up LEFS was 72.4 (range: 60–80).

Conclusion: The mean time to union of the proximal fracture was shorter than the distal fracture. The use of LISS to treat closed STFs using the proposed surgical technique has proved to give favorable results. Further studies using the described technique are needed to justify the achieved results.

Level of evidence: IV (Prospective case series).
The Total Synthesis of Spermine Alkaloid Kukoamine Bimesylate
Authors: Dong Kai
Published: November 2018

The first total synthesis of kukoamine B bimesylate was completed from 1,4-diaminobutane dihydrochloride in 12 steps with a 11.4% overall yield, and all the steps could be carried out at a kilogram scale. The cyano groups were used as the precursor of amino groups to avoid the competitive reaction delicately. The aza-Michael addition reaction, amidation and hydrogenation of the cyano group sequence was streamlined as a general approach towards the synthesis of polyamine structures.
Mermaid Syndrome: A Case Report of a Rare Congenital Anomaly in Full-Term Neonate with Thumb Deformity
Authors: Taee Nadereh , Tarhani Fariba , Goodarzi Mojgan , Safdari Mohammad , Bajelan Amir
Published: November 2018

The mermaid syndrome (sirenomelia) is an extremely rare anomaly, an incidence of 1 in 100,000 births, in which a newborn born with legs joined together featuring a mermaid-like appearance (head and trunk like humans and tail like fish), and in most cases die shortly after birth. Gastrointestinal and urogenital anomalies and single umbilical artery are clinical outcome of this syndrome. There are two important hypotheses for pathogenesis of mermaid syndrome: vitelline artery steal hypothesis and defective blastogenesis hypothesis. The cause of the mermaid syndrome is unknown, but there are some possible factors such as age younger than 20 years and older than 40 years in mother and exposure of fetus to teratogenics. Here, we introduced 19-year-old mother's first neonate with mermaid syndrome. The mother had gestational diabetes mellitus and neonate was born with single lower limb, ambiguous genitalia, and thumb anomalies, and 4 days after birth, the neonate died due to multiple anomalies and imperforated anus.
An Evidence-Based Tool for Safe Configuration of Electronic Health Records: The eSafety Checklist
Authors: Dhillon-Chattha Pritma , McCorkle Ruth , Borycki Elizabeth
Published: November 2018

Background Electronic health records (EHRs) are transforming the way health care is delivered. They are central to improving the quality of patient care and have been attributed to making health care more accessible, reliable, and safe. However, in recent years, evidence suggests that specific features and functions of EHRs can introduce new, unanticipated patient safety concerns that can be mitigated by safe configuration practices.

Objective This article outlines the development of a detailed and comprehensive evidence-based checklist of safe configuration practices for use by clinical informatics professionals when configuring hospital-based EHRs.

Methods A literature review was conducted to synthesize evidence on safe configuration practices; data were analyzed to elicit themes of common EHR system capabilities. Two rounds of testing were completed with end users to inform checklist design and usability. This was followed by a four-member expert panel review, where each item was rated for clarity (clear, not clear), and importance (high, medium, low).

Results An expert panel consisting of three clinical informatics professionals and one health information technology expert reviewed the checklist for clarity and importance. Medium and high importance ratings were considered affirmative responses. Of the 870 items contained in the original checklist, 535 (61.4%) received 100% affirmative agreement among all four panelists. Clinical panelists had a higher affirmative agreement rate of 75.5% (656 items). Upon detailed analysis, items with 100% clinician agreement were retained in the checklist with the exception of 47 items and the addition of 33 items, resulting in a total of 642 items in the final checklist.

Conclusion Safe implementation of EHRs requires consideration of both technical and sociotechnical factors through close collaboration of health information technology and clinical informatics professionals. The recommended practices described in this checklist provide systems implementation guidance that should be considered when EHRs are being configured, implemented, audited, or updated, to improve system safety and usability.
The Influence of Light Exposure in Ambiance during Pregnancy in Maternal and Fetal Outcomes: An Experimental Study
Authors: Sarri Vitor Coca , Ferrari Beatriz Maria , Magalhães Larissa Fernandes , Rodrigues Paula Almeida , Rezende Almir Coelho , Brunherotti Marisa Afonso Andrade
Published: November 2018

Objective The aim of this study is to evaluate whether exposure to different environmental lighting conditions affects the reproductive parameters of pregnant mice and the development of their offspring.

Methods Fifteen pregnant albino mice were divided into three groups: light/dark, light, and dark. The animals were euthanized on day 18 of pregnancy following the Brazilian Good Practice Guide for Euthanasia of Animals. Maternal and fetal specimens were measured and collected for histological evaluation. Analysis of variance (ANOVA) test was used for comparison of the groups considering p ≤ 0.05 to be statistically significant.

Results There was no significant difference in the maternal variables between the three groups. Regarding fetal variables, significant differences were observed in the anthropometric measures between the groups exposed to different environmental lighting conditions, with the highest mean values in the light group. The histological evaluation showed the same structural pattern of the placenta in all groups, which was within the normal range. However, evaluation of the uterus revealed a discrete to moderate number of endometrial glands in the light/dark and light groups, which were poorly developed in most animals. In the fetuses, pulmonary analysis revealed morphological features consistent with the transition from the canalicular to the saccular phase in all groups.

Conclusion Exposure to different environmental lighting conditions had no influence on the reproductive parameters of female mice, while the offspring of mothers exposed to light for 24 hours exhibited better morphometric features.
Simulation of plasma turbulence in the periphery of diverted tokamak by using the GBS code
Authors: Paruta Paola , Ricci P. , Riva F. , Wersal C. , Beadle C. , Frei B.
Published: November 2018

We report on the implementation of diverted magnetic equilibria in GBS and on first simulations in this geometry. GBS is a simulation code used to evolve plasma turbulence in the tokamak periphery by solving the drift-reduced Braginskii's equations. The model equations are written in toroidal coordinates, abandoning flux coordinate systems that are not defined at the X-point. A fourth order finite difference scheme is used for the implementation of the spatial operators on poloidally and toroidally staggered grids. The GBS numerical implementation is verified through the method of manufactured solutions. The code convergence properties are tested on a relatively simple analytical X-point configuration. Finally, the diverted equilibrium from a TCV tokamak discharge is implemented in the new version of GBS. The analysis of the simulation results is focused on blob formation, radial transport, and plasma poloidal rotation mechanisms.
Simpler is often better: Computational efficiency of explicitly correlated two-electron basis sets generated by the regularized Krylov sequences of Nakatsuji
Authors: Cioslowski Jerzy , Pra̧tnicki Filip
Published: November 2018

A measure Δ of computational efficiency of the explicitly correlated basis sets (XCBSs) generated by the regularized Krylov sequences of Nakatsuji (also known as “the free complement” or “the free iterative CI” method) is derived from the convergence characteristics of the underlying iterative process. A complete mathematical definition of this process, which includes a crucial projection operator undefined in previous publications, is provided. Comparison of the values of Δ pertaining to several XCBSs designed for the helium isoelectronic series (for which Δ = −K−1/3 ln ϵ, where ϵ is the error in the computed energy and K is the number of the basis functions comprising the basis set) leads to a surprising conclusion that, among sufficiently large XCBSs, those stemming from the seed basis sets (SBSs) independent of the interelectron distance are the most efficient ones. Consequently, taking into account the simplicity of the resulting matrix elements of diverse quantum-mechanical operators, the XCBSs generated from the {exp(−ζs), s1/2 exp(−ζs)} SBS (where s is the first of the Hylleraas coordinates) appear to be best suited for extremely accurate electronic structure calculations on helium-like species.
Electronic structure theory gives insights into the higher efficiency of the PTB electron-donor polymers for organic photovoltaics in comparison with prototypical P3HT
Authors: Modesto-Costa Lucas , Borges Itamar , Aquino Adélia J. A. , Lischka Hans
Published: November 2018

The electron donor poly-thienothiophene-benzodithiophene (PTB) polymer series displays remarkable properties that lead to more efficient bulk heterojunction (BHJ) organic solar cells. In this work, the ground and four excited states (bright S1 and dark S2–S4) of three different members of the PTBn (n = 1, 6, 7) series were studied and compared with the prototypical poly(3-hexylthiophene) (P3HT) donor polymer. Time-dependent density functional theory was employed to investigate oligomers of similar sizes (∼50 Å). Charge alternation electron accumulation and depletion regions of the four transitions are concentrated on the inner units, thereby favoring interaction with the electron acceptor in a BHJ. The bright S1 transition energies of PTBn are about 0.2 eV lower as compared to P3HT, thereby allowing a better match of their levels with the typical C60-type acceptor moiety in a BHJ. Side chains play a minor role in the electronic spectrum (less than ∼0.1 eV). The most efficient PTB7 transfers more electronic charge from its electron-rich benzodithiophene subunit to its electron-deficient thieno[3,4-b] thiophene subunit as compared to PTB1 and PTB6. We show that the dipolar effect, a partial concentration of negative and positive charges on the different parts of the donor polymer that favors charge separation, is more pronounced in PTBn polymers and typically an order of magnitude larger as compared to P3HT. These effects are conspicuous for the most efficient polymer of the series, PTB7, with its fluorine substituent shown to play a crucial role.
Reductions in quality of life and increased economic burden associated with mental disorders in an Australian adult sample
Authors: McCallum Sonia M. , Batterham Philip J. , Calear Alison L. , Sunderland Matthew , Carragher Natacha
Published: November 2018

Objective
The aim of this study was to determine the effect of a broad range of common mental disorders and their comorbidity on health-related quality of life and functional disability.

Methods
In all, 2734 Australians aged ≥18 years, recruited from the general community via Facebook during August–December 2014, completed an online survey assessing demographic characteristics, nine mental disorders, suicidal ideation and attempt. Outcome measures were health-related quality of life (assessed using the Assessment of Quality of Life (AQoL)-4D measure and functional disability (days out of role).

Results
Overall, 53.1% of the sample met criteria for at least one mental disorder. Participants with each of the 11 mental health problems had significantly lower mean AQoL-4D scores and significantly greater functional disability compared with not having the disorder (P<0.001). A monotonic decrease in quality of life and an increase in functional disability were observed with an increased total number of comorbid disorders (P<0.001). Accounting for disorder prevalence, annual economic burden for each mental disorder was estimated to be in the range of A$870 million–A$17 billion.

Conclusions
Mental disorders negatively affect health-related quality of life and functional disability, exacerbated by increased comorbidity. The economic burden to participants and employers estimated in this study is of concern, and highlights the importance of evidence-based treatment and prevention approaches.

What is known about the topic?
Mental disorders are associated with poorer health-related quality of life, increased functional disability and increased economic costs.

What does this paper add?
This paper furthers our understanding of the associations of nine mental disorders, suicidal ideation and suicide attempts with quality of life in an Australian setting, highlighting the considerable economic implications of these associations. Further, it reveals that comorbidity of mental disorders exacerbates reductions in quality of life and increased functional disability.

What are the implications for practitioners?
The economic burden associated with lost productivity and quality of life for individuals with mental disorders is considerable. Therefore, prioritising funding to prevention and treatment using evidence-based approaches will have significant effect in terms of economic productivity and personal well-being for individuals.
Identification of differentially expressed microRNAs in outgrowth embryos compared with blastocysts and non-outgrowth embryos in mice
Authors: Kim Jihyun , Lee Jaewang , Jun Jin Hyun
Published: November 2018

Recurrent implantation failure (RIF) is one of the main causes for the repeated failure of IVF, and the major reason for RIF is thought to be a miscommunication between the embryo and uterus. However, the exact mechanism underlying embryo–uterus cross-talk is not fully understood. The aim of the present study was to identify differentially expressed microRNAs (miRNAs) among blastocysts, non-outgrowth and outgrowth embryos in mice using microarray analysis. A bioinformatics analysis was performed to predict the potential mechanisms of implantation. The miRNA expression profiles differed significantly between non-outgrowth and outgrowth embryos. In all, 3163 miRNAs were detected in blastocysts and outgrowth embryos. Of these, 10 miRNA candidates (let-7b, miR-23a, miR-27a, miR-92a, miR-183, miR-200c, miR-291a, miR-425, miR-429 and miR-652) were identified as significant differentially expressed miRNAs of outgrowth embryos by in silico analysis. The expression of the miRNA candidates was markedly changed during preimplantation embryo development. In particular, let-7b-5p, miR-200c-3p and miR-23a-3p were significantly upregulated in outgrowth embryos compared with non-outgrowth blastocysts. Overall, differentially expressed miRNAs in outgrowth embryos compared with blastocysts and non-outgrowth embryos could be involved in embryo attachment, and interaction between the embryo proper and maternal endometrium during the implantation process.
Epstein–Barr virus enhances genome maintenance of Kaposi sarcoma-associated herpesvirus
Authors: Bigi Rachele , Landis Justin T. , An Hyowon , Caro-Vegas Carolina , Raab-Traub Nancy , Dittmer Dirk P.
Published: November 2018

Significance

Primary effusion lymphoma (PEL) is a B cell lymphoma; the prognosis is poor, with a median survival around 6 months. PEL is always associated with the presence of Kaposi’s sarcoma-associated herpesvirus and in most cases is coinfected with Epstein–Barr virus (EBV); however, the role of EBV in the pathogenesis of the tumor is still not clear. This study demonstrates the intricate interaction between the two herpesviruses, which exacerbate tumorigenesis by mutually reinforcing the persistence of each latent genome and by altering cell proliferation. It establishes curing EBV and inhibiting Epstein–Barr nuclear antigen 1 as a potential treatment for PEL.
Aberrant IP
3
receptor activities revealed by comprehensive analysis of pathological mutations causing spinocerebellar ataxia 29
Authors: Ando Hideaki , Hirose Matsumi , Mikoshiba Katsuhiko
Published: November 2018

Significance

Spinocerebellar ataxias (SCAs) are neurological disorders caused by cerebellar dysfunction. Missense mutations in inositol 1,4,5-trisphosphate (IP
3
) receptor type 1 (IP
3
R1), an IP
3
-gated intracellular Ca
2+
channel, are associated with infantile-onset nonprogressive SCA. However, the molecular mechanisms of how mutations in IP
3
R1 cause SCA remain unclear. We demonstrated that pathological mutations in IP
3
R1 disrupt IP
3
R1 channel activity either by reducing IP
3
-binding affinity or hindering channel gating elicited by IP
3
binding. Furthermore, disease-causing mutations in IP
3
R1 or carbonic anhydrase-related protein VIII (CA8), an IP
3
R1-regulating protein abundantly expressed in cerebellar neurons, abrogated the IP
3
R1–CA8 interaction and CA8-mediated regulation of IP
3
R1. These results suggest that aberrant calcium homeostasis in cerebellar neurons caused by dysfunctions of IP
3
R1 are responsible for SCA pathogenesis.
Episodic organic carbon fluxes from surface ocean to abyssal depths during long-term monitoring in NE Pacific
Authors: Smith Kenneth L. , Ruhl Henry A. , Huffard Christine L. , Messié Monique , Kahru Mati
Published: November 2018

Significance

Ignoring temporal fluctuations in the oceanic carbon budget leads to a significant misrepresentation of the cycling of organic matter from production in surface waters to consumption and sequestration in the abyssal ocean. A 29-year time series (1989 to 2017) of particulate organic carbon (POC) fluxes and sea-floor measurements of sediment community oxygen consumption (SCOC) revealed episodic, high-magnitude events over the past 7 years. Time lags between changes in satellite-estimated export flux, POC flux and SCOC varied from 0 to 70 days. A commonly used model to estimate carbon flux through the water column significantly underestimated the measured carbon fluxes by almost 50%. Episodic pulses of organic carbon into the deep sea must be accounted for to balance the oceanic carbon budget.
Strong Integration in bilingual grammar, formalized
Authors: Hsin Lisa , Legendre Geraldine
Published: November 2018

We present elicited production data reflecting cross-linguistic interference effects in the English wh-questions of Spanish-English bilingual children to provide a proof-of-concept for a proposed new formal analysis of such effects across cross-linguistic influence phenomena. The observed interference effects are interpreted as evidence for the Strong Integration hypothesis of bilingual grammatical architecture, in the context of independently documented facilitation and interference effects in a range of bilingual acquisition contexts. Building on an existing Optimality-Theoretic (OT) model of monolingual acquisition and a specific account of the adult grammar of wh-structures across dialects of Spanish, we propose that the individual patterns documented, in particular the sensitivity in child English to distinctions made in Spanish dialects on the basis of an argument/adjunct contrast, find a straightforward explanation in the OT model of acquisition as adapted to bilingual situations. The generalizability of the model as well as effects of exposure and dominance are discussed.
Renegade Cosmopolitans: Iranian Architects, Professional Power, and the State
Authors: Roudbari Shawhin
Published: November 2018

Through migration, professional activism, and by engaging the symbolic terrain of architecture magazines and competitions, Iranian architects have sought to make their profession cosmopolitan. But following decades of isolationist tendencies, factions of the Iranian architecture profession continue to meet resistance from elements of the state. The profession’s institutions have become a battleground for the expression of the power of design professionals. Building on scholarship on relationships between states and professions as well as professionals’ expressions of cosmopolitanism, this paper demonstrates ways everyday professionals leverage their institutions for professional power. It shares accounts from a transnational ethnography of Iranian architects to show how, on the one hand, professional change seeps outside restrictions attributed to political and economic borders. On the other hand, the stories of cosmopolitan professionals show that the state need not be bound by structural sanctions, like those Iran has faced, in its efforts to cultivate an avant-garde.
Populism in Southern Africa under liberation movements as governments
Authors: Melber Henning
Published: November 2018

Anti-colonial movements secured political power as governments in countries of Southern Africa. Populist discourses, which reinforce the patriotic history and heroic narratives of a ‘big men’ syndrome, are part of their political culture retaining continued legitimacy, not least in South Africa, Namibia and Zimbabwe, where national sovereignty was the result of a negotiated transfer of political power. This briefing presents a critical assessment of such populism as an integral part of the repertoire of former liberation movements as governments.
Contemporary local governance and indigenous institutions: the case of the Sidaama, Southern Ethiopia
Authors: Kia Tsegaye Tuke
Published: November 2018

In the contemporary world, enormous changes and improvement are taking place in governance practices throughout the world. Democratic decentralization, in particular, has become a serious concern in many countries, especially in developing countries like Ethiopia. Successive Ethiopian governments have introduced and implemented modern governance system. This happened despite the existence of indigenous institutions which have been playing an indispensable role in guiding the social-political lives of the societies, especially for the rural area communities in filling the gap of the formal state institutions. Given the limitations of modern institutions, relying on traditional institutions could be an attractive option to improve local governance. This is because, when compared with state institutions, traditional institutions do not need to build from the beginning. At the local level creating new and efficient state institutions can be difficult and costly and time-consuming. Accordingly, the qualitative research methodology was employed in the study for its appropriateness to investigate indigenous institutions and local governance by collecting practical evidence from Sidaama province. Eventually, the findings of the study revealed that properly employing indigenous institutions are good mechanisms for improving the performance of formal local governance institutions in the study area.
Interviewing in Criminal and Intelligence-Gathering Contexts: Applying Science
Authors: Wells Simon , Brandon Susan E.
Published: November 2018

This article provides a framework for the application of science-based interview methods to interviews conducted in both criminal and intelligence interview contexts. In these contexts, subjects frequently are antagonistic and many have experienced some kind of trauma. Similar to mental health professionals who conduct face-to-face interviews in prisons and hospitals, there is the need to gain as much valid and useful information as possible to make informed decisions. Our framework consists of three phases: in-depth planning, engagement, and sensemaking. We include a description of moments of a real-life criminal interview to illustrate the framework, and then briefly address some of the cultural and ethical challenges inherent to this domain.
Beata Mierzwa: Bridging the divide between science and art
Authors: Infarinato Nicole
Published: November 2018

Mierzwa studies mechanisms of cell division in different cell types and tissue contexts.
On uncountable strongly concentrated sets of reals
Authors: Bilinsky Eilon
Published: November 2018

We construct new models of ZF with an uncountable set of reals that has a unique condensation point. This addresses a question of Sierpiński from 1918.
Simple Whittaker modules over free bosonic orbifold vertex operator algebras
Authors: Hartwig Jonas , Yu Nina
Published: November 2018

We construct weak (i.e. nongraded) modules over the vertex operator algebra

M
(
1

)
+

M(1)^+

, which is the fixed-point subalgebra of the higher rank free bosonic (Heisenberg) vertex operator algebra with respect to the

−
1

-1

automorphism. These weak modules are constructed from Whittaker modules for the higher rank Heisenberg algebra. We prove that the modules are simple as weak modules over

M
(
1

)
+

M(1)^+

and calculate their Whittaker type when regarded as modules for the Virasoro Lie algebra. Lastly, we show that any Whittaker module for the Virasoro Lie algebra occurs in this way. These results are a higher rank generalization of some results by Tanabe [Proc. Amer. Math. Soc. 145 (2017), no. 10, pp. 4127–4140].
Vector-valued modular forms on a three-dimensional ball
Authors: Freitag Eberhard , Manni Riccardo
Published: November 2018

In this paper we give a structure theorem for the module of vector valued modular forms in the case of a three dimensional ball with the action of the Picard modular group

Γ
3

[

−
3

]

\Gamma _3 [\sqrt {-3}]

. The corresponding modular variety of dimension

3
3

is a copy of the Segre cubic.
An infinite sequence of conserved quantities for the cubic Gross–Pitaevskii hierarchy on ℝ
Authors: Mendelson Dana , Nahmod Andrea , Pavlović Nataša , Staffilani Gigliola
Published: November 2018

We consider the cubic Gross–Pitaevskii (GP) hierarchy on

R

\mathbb {R}

, which is an infinite hierarchy of coupled linear inhomogeneous partial differential equations appearing in the derivation of the cubic nonlinear Schrödinger equation from quantum many-particle systems. In this work, we identify an infinite sequence of operators which generate infinitely many conserved quantities for solutions of the GP hierarchy.
Analytic continuations of log-exp-analytic germs
Authors: Kaiser Tobias , Speissegger Patrick
Published: November 2018

We describe maximal, in a sense made precise,

L

\mathbb {L}

-analytic continuations of germs at

+
∞

+\infty

of unary functions definable in the o-minimal structure

R

an,exp

\mathbb {R}_\textrm {an,exp}

on the Riemann surface

L

\mathbb {L}

of the logarithm. As one application, we give an upper bound on the logarithmic-exponential complexity of the compositional inverse of an infinitely increasing such germ, in terms of its own logarithmic-exponential complexity and its level. As a second application, we strengthen Wilkie’s theorem on definable complex analytic continuations of germs belonging to the residue field

R

poly

\mathcal {R}_{\text {poly}}

of the valuation ring of all polynomially bounded definable germs.
ADP-ribosylation factor–like 4A interacts with Robo1 to promote cell migration by regulating Cdc42 activation
Authors: Chiang Tsai-Shin , Lin Ming-Chieh , Tsai Meng-Chen , Chen Chieh-Hsin , Jang Li-Ting , Lee Fang-Jen S.
Published: November 2018

Cell migration is a highly regulated event that is initiated by cell membrane protrusion and actin reorganization. Robo1, a single-pass transmembrane receptor, is crucial for neuronal guidance and cell migration. ADP-ribosylation factor (Arf)–like 4A (Arl4A), an Arf small GTPase, functions in cell morphology, cell migration, and actin cytoskeleton remodeling; however, the molecular mechanisms of Arl4A in cell migration are unclear. Here, we report that the binding of Arl4A to Robo1 modulates cell migration by promoting Cdc42 activation. We found that Arl4A interacts with Robo1 in a GTP-dependent manner and that the Robo1 amino acid residues 1394–1398 are required for this interaction. The Arl4A-Robo1 interaction is essential for Arl4A-induced cell migration and Cdc42 activation but not for the plasma membrane localization of Robo1. In addition, we show that the binding of Arl4A to Robo1 decreases the association of Robo1 with the Cdc42 GTPase-activating protein srGAP1. Furthermore, Slit2/Robo1 binding down-regulates the Arl4A-Robo1 interaction in vivo, thus attenuating Cdc42-mediated cell migration. Therefore, our study reveals a novel mechanism by which Arl4A participates in Slit2/Robo1 signaling to modulate cell motility by regulating Cdc42 activity.
The roles of a flagellar HSP40 ensuring rhythmic beating
Authors: Zhu Xiaoyan , Poghosyan Emiliya , Rezabkova Lenka , Mehall Bridget , Sakakibara Hitoshi , Hirono Masafumi , Kamiya Ritsu , Ishikawa Takashi , Yang Pinfen
Published: November 2018

HSP40s are regarded as cochaperones, perpetually shuttling client polypeptides to HSP70s for refolding. However, many HSP40s that are central for disparate processes diverge from this paradigm. To elucidate the noncanonical mechanisms, we investigated HSP40 in the radial spoke (RS) complex in flagella. Disruption of the gene by the MRC1 transposon in Chlamydomonas resulted in jerky flagella. Traditional electron microscopy, cryo-electron tomography, and sub-tomogram analysis revealed RSs of various altered morphologies that, unexpectedly, differed between the two RS species. This indicates that HSP40 locks the RS into a functionally rigid conformation, facilitating its interactions with the adjacent central pair apparatus for transducing locally varied mechanical feedback, which permits rhythmic beating. Missing HSP40, like missing RSs, could be restored in a tip-to-base direction when HSP40 mutants fused with a HSP40 donor cell. However, without concomitant de novo RS assembly, the repair was exceedingly slow, suggesting HSP40/RS-coupled intraflagellar trafficking and assembly. Biochemical analysis and modeling uncovered spoke HSP40’s cochaperone traits. On the basis of our data, we propose that HSP40 accompanies its client RS precursor when traveling to the flagellar tip. Upon arrival, both refold in concert to assemble into the mature configuration. HSP40’s roles in chaperoning and structural maintenance shed new light on its versatility and flagellar biology.