bluuebunny/crossref_metadata_2025 huggingface dataset:
Antidiabetic activity of extracts of Pistachia khinjuk on alloxan monohydrate induced diabetic mice
Authors: Shahid Sammia , Taj Saima
Published: March 2019

Diabetes is spreading all over the world day by day. There are many ways to treat diabetes mellitus which mainly includes synthetic drugs, homeopathic medicine or Unani medicine etc. These Medicines have many side effects. Natural products; which include herbs, shrubs and large plants, cure diabetes mellitus and prove excellent hypoglycemic activity. These herbal medicines have no reported side effects. Many species of family Anacardiaceae show hypoglycemic activity and used from centuries to cure diabetes. Various pistachio species show hypoglycemic activity and have a very long history of herbal remedies. The present study evaluates the hypoglycemic effect of methanolic extract ofPistachia khinjuk.Six groups of Swiss albino mice were made for extract (80:20 Methanol: water) ofPistachia khinjukand each group contains six albino mice. All the mice were injected alloxan monohydrate except normal group of wax and extract. Group 1 was treated as normal group and receives no treatment, group 2 receive 5mg/kg of glibenclamide after alloxan monohydrate induction, group 3 receive no treatment after alloxan monohydrate induction, group 4 and 5 receive 500 and 250mg/kg ofPistachia khinjukextract, while group 6 receives 500mg/kgPistachia khinjukwax after alloxan monohydrate treatment. All the mice for extract (Pistachia khinjuk) of group 4, 5 and 6 show hypoglycemic activity and decreases blood glucose level. There may be many factors behind this activity which needs more research on it by isolating and analyzing specific secondary metabolites which causes this effect. The methanolic extract due to phenolic constituents proves to be excellent antidiabetic medicine.
Estimation of the probability of karst cavities collapse under technogenic cyclic loads below the fatigue limit
Authors: Kuzichkin O R , Dorofeev N V , Grecheneva A V , Romanov R V , Surzhik D I
Published: March 2019

The paper deals with the phenomenon of fatigue formation in soils over karst cavities under cyclic loading near the fatigue limit. A method is proposed for determining the stress state of the integumentary earth arising during the considered technogenic cyclic loads. Currently, the assessment of the possibility of karst cavities collapse is performed on the basis of static models, without taking into account the dynamic technogenic load. Especially in the case of slow cyclic loads of low intensity, which do not directly lead to collapse of the soil above the karst cavities. However, these actions change the bearing capacity of soils that are not taken into account at the exploration stage and are not laid in the project documentation for the construction of facilities in karst-dangerous areas. A technique for estimating pre-crisis states based on joint processing of active geoelectric and seismoacoustic geodynamic control signals is proposed.
Study on batching and picking optimization of marine outfitting pallets
Authors: Zhao D G , Jiang Y , Bao J W , Wang J Q , Jia H
Published: March 2019

Outfitting pallet picking involves the retrieval of items from their storage sites in shipbuilding enterprises. A major issue in manual pallet picking operations is the transformation of outfitting pallets into picking batches (pallet batching). Considering the influence to the subsequent distribution and production processes, a mathematical model for the batching and picking problem of outfitting pallets is formulated with the objective of minimizing the total tardiness of all pallets. According to the characteristics of outfitting pallet picking operations, an Improved Genetic Algorithm (IGA) is proposed. A reversal operator is specially introduced to increase the local search ability of the standard genetic algorithm and speed up the evolution. Benchmarked against the solutions produced by the Earliest Due Date (EDD) rule, the performance of IGA is studied under different picking operations with different workloads and tightness of due dates. A series of numerical experiments are carried out to verify the researches. The results clearly show that IGA is competitive since it improves the solutions by 68.5%, on average, relative to the EDD.
Location-based fatigue damage assessment on an FPSO by the spectral analysis method
Authors: Viswanathan A , Subramanian V A , Kumar D
Published: March 2019

Floating production storage and offloading ships (FPSOs) are offshore platforms positioned at a location and operating at different loading conditions and corresponding draughts. Due to their static location, they get subjected to continuous fluctuating loads due to the sea environment. For these reasons the fatigue damage prediction of an FPSO is essential. The emphasis of this study is on the effect of fatigue damage at critical joints of critical structural members under the influence of vertical and horizontal bending in isolation and combination. The method considers an FPSO of 320m length for a case study, selecting a total of fourteen such structural member locations along the periphery at its midship section. The analysis considers two necessary loading conditions namely, fully loaded and ballast condition. The study uses spectral fatigue analysis method wherein the bending moment transfer function generates the stress transfer function, which in turn helps to generate the power spectral density function. Combining the spectral moments with Palmgren-Miner rule gives the cumulative fatigue damage of the FPSO. The results provide an insight into the variation in fatigue damage concerning the location of the structural member under the influence of vertical and horizontal bending moments.
Calculation of land social security value in the process of urban non-agricultural construction land transfer--Based on field investigation in rural areas of Guangzhou
Authors: Fang Wei , Liang Junfen , Kang Le
Published: March 2019

The social security value of land includes four major items, namely, unemployment security, minimum living security value, old-age security value and medical security value. The non-agricultural construction land compensation substance produced in the process of social security is the land value of the market price, the farmers and urban residents, land value can be partial social security. To determine the process of land expropriation for non-agricultural construction reasonable compensation, we need to provide scientific standards. Through the calculation, Guangzhou ’ s current land compensation provide social security value of basic level, but due to the large regional land requisition compensation amount difference, the current land expropriation compensation is actually the coexistence of insufficient and transition compensation.
The untapped impact: Struggles and subsequent condition of Metro Manila taxi industry amid operations of Transport Network Companies
Authors: Beltran N J , Jesus R De , Alipio L R , Maynite E , Clemente C , Gonzales Ñ R , Silagan N J
Published: March 2019

In 2015, Transport Network Companies (TNC) such as Grab and Uber were introduced in the Philippines. With the worsening traffic management system in the country, TNC units use the power of an application to cater the commuting needs and demands of the Filipino commuting public following a car-sharing principle. Taking into account their startup success, the conventional taxi industry has been struggling. On this basis, this phenomenological study therefore involves an in-depth understanding of the struggles and subsequent condition of the taxi industry amid operations of TNCs. With the use of snowball and convenience sampling, the study involved semi-structured interviews with drivers of conventional taxi, commuters, and the Philippines' Land Transportation Franchising and Regulatory Board (LTFRB) members to obtain perspectives from the regulating body. Employing Billups’(2016) qualitative data analysis method, six themes emerged including Effects of Transport Network Companies, Protests and Complaints of Taxi Drivers, Consequent Actions of Taxi Drivers due to Income Reduction, Motivations for Taxi Driving Business Continuity, Perceptions of Taxi Drivers on TNVS, and Commuter Perspective on both Transport Services. Based on the findings, it is concluded that since the TNCs introduction, the conventional taxi industry has been bombarded of varied issues relating to the quality of transport service they provide in terms of convenience, comfort and ease, affordability, and accessibility. These findings then translate to the need of a partial deregulation that involves amendments on some memorandum circulars, and the pioneered Code of Ethics for the entire Philippine Taxi Industry so as to sustain and correspondingly compete with TNCs in relation to the demands of the market.
Assessing the operations of commuter rail: A case study in KRL commuter line of Jakarta Metropolitan Area
Authors: Ulkhaq M M , Widodo A K , Izati N , Santoso S Y , Sutrimo W H W M , Akshinta P Y
Published: March 2019

Public transportation is considered to be able to handle several transportation problems, such as “the ancient” traffic congestion to “the contemporary” environmental impact. Rail transit, or also known as commuter rail, is one of the most important public transportation types since it could reduce effectively the traffic congestion. At this instant, service quality of commuter rail is essential to achieve the customer satisfaction. This research aims to assess the operations of commuter rail by assessing its service quality. The importance-performance and gap analysis (IPGA) based on nine criteria was applied to accomplish the objective. A case study was conducted in KRL commuter line of Jakarta Metropolitan Area which is operated by P.T. Kereta Commuter Indonesia. The result shows that the safety criterion has the highest relative importance score and the fare has the highest relative performance score. The IPGA technique then was employed to build strategies based on the relative importance and performance from the passengers’ point of view.
Analysis of the feasibility and necessity of special road construction for small passenger cars
Authors: He Jin , Chang Pengfei , Sun Yanjie
Published: March 2019

The rapid development of social economy has caused many problems in highway transportation. The traffic on most roads is getting bigger and bigger. This trend not only increases traffic pressure but also poses a threat to the lives of travellers. In order to solve the current road traffic problem, this paper proposes a special route for the construction of small passenger vehicles. The basic idea of dedicated line construction is based on the secondary road and highway operation forms. Each line passes through 1 to 3 townships. The internal and external environment and advantages and disadvantages of the dedicated line construction were analyzed by SWOT method, and the SWOT matrix was constructed. The analysis results show that the small passenger dedicated line is feasible and necessary, and has a good development prospect. In this way, it provides a new idea for the development of China’s highways.
The method and devices of autocompensation of phase distortions of direct digital synthesizers of signal formers of georadars
Authors: Dorofeev N V , Grecheneva A V , Kuzichkin O R , Surzhik D I , Romanov R V
Published: March 2019

The method for isolating the clock frequency of direct digital synthesizers, as well as algorithms and devices for isolating and automatically compensating phase distortions, that significantly improve the spectral characteristics of the formers of the probing signals of georadars used for geodynamic monitoring are considered in the article.
The method is substantiated, explanatory oscillograms, spectrograms, and the results of the experimental researches, confirming the authenticity, are presented.
Complex processing of goniometric and acoustic signals in the automated control system of the rehabilitation exoskeleton
Authors: Dorofeev N V , Grecheneva A V , Kuzichkin O R
Published: March 2019

The technique of express-assessment of intervertebral disk changes is described. This technique is based on the automation of goniometric and arthrophonometric measurements to reduce of the trauma in the regulation and using of the rehabilitation exoskeleton. It is characterized by the application of an individual biomechanical model of a human being, built on the basis of an individual n-shaped angular model and a three-dimensional biomechanical model. The using wavelet filtering and neural network algorithms for the detection and classification of pathologies when processing of the goniometric and atrofonometric data.
The developed technique is adaptive: the parameters of models and processing units are adjusted to the physiological characteristics of the patient, the neural network coefficients are automatically adjusted during the diagnostics. The processing of acoustic signals is carried out in several bands with interference compensation. Goniometric measurements are built on the basis of an accelerometric phase-metric system. A generalized structure of the influence of biochemical and biophysical factors on the change of intervertebral discs was developed.
Research on mobile application support system based on internal and external network
Authors: Wu He , Qiao Lin , Chen Shuo , Liu Wei , Li Feng
Published: March 2019

Since 13th Five-Year, great changes have taken place in the situation at home and abroad. Internal and external factors such as “Internet +” innovation and development, new technology driven and information security situation have had a wide and profound impact on the production and operation of enterprises. At the same time, new requirements for information and communication work have been put forward. Based on the existing internal and external network structure of the enterprise, we study a fast response, collaborative innovation, security and controllable mobile application support system, so as to speed up the construction of enterprise mobile applications, and help “Internet +” management innovation and business innovation.
Implementation of micro application storage with high reliability based on Oracle 12c
Authors: Chen Jian , Wang Danni , Qiao Lin
Published: March 2019

This paper proposes the implementation of data storage structure with high reliability based on the characteristics of Oracle 12c. On the basis of micro application platform, the main advantages of data structure works out active-active or multi-active problems of hardware storage device and ensures that the business can still be able to use data source to carry on data manipulation under the circumstances of one or multiple data sources corruption, so as to guarantee the whole business without interruption. This paper makes detailed introduction of each module in the system structure, conducts brief description, comparison and analysis on disseminating algorithm of data manipulation and comparison algorithm of the same data source, and carries on detailed proof and explanation of the use of various algorithms in the actual use procedure.
CFD Study on Effects of Geometric Shape and Surface Hydrophilicity and Hydrophobicity on the Drainage Capacity of Plant Leaves
Authors: Yong Nam Yun , Chao Wu
Published: March 2019

The photosynthesis process of plant requires fast removal of surface contaminant of leaves. The removal of surface contaminants is highly related to the drainage capacity of the leaf. This paper conducted a comprehensive study on the drainage capacity of plant leaves. The effects of both leaf shape and leaf hydrophilicity/hydrophobicity are investigated. This paper uses Computational Fluid Dynamics (CFD) technology to simulate the drainage process of plant leaves. The numerical simulation results indicate that hydrophilic leaves requires the sharp parts on the edges to remove the water. On the other hand, the drainage capacity of hydrophobic leaves is independent of the shape of the leaves.
Determination of Heat Transfer Coefficient of Two Insulated Cotton Based on Wall Framing
Authors: Lu Yao , Xie Wenbo , Wang Zheng
Published: March 2019

The heat preservation performance of the light wood frame construction wall directly affects the energy saving effect of the light wood frame construction. In order to strengthen the research of the thermal performance of the light wood structure wall and sandwich wall, in this paper, the heat transfer coefficient of glass-insulated cotton with two kinds of materials was measured in the exterior wall of the same light-weight wooden structure through field test method for heat transfer coefficient of construction so as to compare the test value and theory of the wall insulation coefficient Value, and preferably a thermal insulation cotton filling material. The conclusion shows that the wall filling material of guardian glass insulation performance is better than the Owens Corning Glass insulation cotton, and the former is adapted to the area of hot summer and cold winter and hot in summer and warm in winter, which is suitable for the hot summer and warm winter area. This paper is helpful to promote the energy saving optimization design of the wall structure of the light wood frame construction, and the engineering application value is high. Calculating the heat-conducting value of light wood structure wall, and the calculated values of the temperature of the constituent materials are comparable with the measured values actually, and the composite material theory can be used to predict the heat-conducting property of wood structure construction. The above is mentioned help to improve the level of on-site testing technology of heat-conducting, and provide a useful reference for the energy-saving insulation design work for light wood structure wall in our country, and this study has a high engineering application value.
Experimental study on LBL beams
Authors: Zhao Chenjie , Xiong Xiaohong , Xiong Zhenhua , Wu Kangwen , Cao Zhen , Shao Miao , Cao Tongwei , Dong Haoran , Ding Jieying , Zhao Chenge , Xie Yuxuan , Jia Xue , Liu Baofeng , Liu Can , Jiang Langkun , Liu Wenfeng , Wei Dongdong , Yuan Conggan , Li Xinjie
Published: March 2019

Six specimens were made and tested to study the mechanical properties of LBL beams. The mean ultimate loading value is 68.39 MPa with a standard deviation of 6.37 MPa, giving a characteristic strength (expected to be exceeded by 95% of specimens) of 57.91 MPa, and the mean ultimate deflection is 53.3 mm with a standard deviation of 5.5 mm, giving the characteristic elastic modulus of 44.3 mm. The mean ultimate bending moment is 20.18 kN.m with a standard deviation of 1.88 kN.m, giving the characteristic elastic modulus of 17.08 kN.m. The mean elastic modulus is 9688 MPa with a standard deviation of 1765 MPa, giving the characteristic elastic modulus of 6785 MPa, and the mean modulus of rupture is 93.3 MPa with a standard deviation of 8.6 MPa, giving the characteristic elastic modulus of 79.2 MPa. The strain across the cross-section for all LBL beams is basically linear throughout the loading process, following standard beam theory.
Nacre inspired 3D printing construction for high performance structural member
Authors: Yu Jiangtao , Ye Junhong
Published: March 2019

Inspired by the nacre’s hierarchically assembled structure, the authors tried to use ultra-high ductile cementitious composites (UHDCC) and stack approach to fabricate structure possessing high flexural ductility and load bearing capacity. A series of beams with specially design was constructed, i.e., monolithically cast beams, monolithically stacked beams and hierarchically stacked beams. Four-point bending tests were carried out to explore the effect of hierarchical assembly on load bearing capacity, flexural deformation and flexural toughness. The test results have indicated that the monolithically stacked beams outperform the monolithically cast beams in both deformability and loading bearing capacity, indicating the effectiveness of stack-based construction. Moreover, the setup of connect/separation between layers further improves the flexural ductility of the hierarchically stacked beams, as compared with the monolithically stacked beams. Digital Image Correlation (DIC) observations indicate that the nacreous-like structure of the hierarchically stacked beam helps to trigger crack deflecting and branching between layers and inside matrix, lead to limited slide between layers, thus effectively relieving concentrated strain inside matrix, postponing the emergence of the critical crack and consequently improving the flexural ductility of nacreous-like UHDCC beams.
Numerical simulation of chloride diffusion in cementitious materials by lattice type model
Authors: Li Tianhua , Pan Zichao , Bai Wenying , Zhang Kejia
Published: March 2019

The chloride ingress is one of the most significant problems to reinforced concrete structures in coastal areas and cold regions where the de-icing salt is commonly used. In this paper, the lattice type model which has been widely used in fracture analysis of brittle materials is applied to simulate the chloride diffusion process in cementitious materials. The theoretical background of the lattice type model in solving the mass transport problem is briefly presented. The analytical solution of the Fick’s law is adopted to theoretically validate the developed lattice type model. After that, two typical case studies are included to demonstrate the application of the lattice type model in the chloride ingress issue. In the first case, the tortuosity effect of the aggregates on the chloride diffusion front at meso-scale is studied by the lattice model. In the second case, the lattice model is applied in the simulation of the chloride diffusion in cracked concrete. The results show that the lattice type model can be a useful tool to simulate the chloride ingress in the cementitious materials.
Experimental study on seismic behavior of shear wall with fiber reinforced polymer concrete
Authors: SONG Xing-yu , HOU Qin , CHEN Lei
Published: March 2019

In order to improve the seismic performance of common concrete shear wall with concealed bracings, fiber reinforced polymer modified concrete instead of ordinary concrete was applied to the shear wall as described in this paper. In this paper, the experimental study on the seismic performance of two different types of shear walls under cyclic loading was carried out, and also the failure characteristics, bearing capacity, ductility, hysteretic curve, stiffness attenuation and energy dissipation performance of the proposed shear wall were analyzed systematically. The test results show that the seismic performance of fiber-reinforced polymer modified concrete shear wall is significantly improved because its the damping ratio, deformation capacity and energy dissipation capacity are greatly improved compared with ordinary concrete shear wall with concealed bracings, which ensures its better stiffness stability in the later stage.
Development of high strength self-compacting fibre reinforced concrete for prefabricated concrete industry
Authors: Garcez Estela O. , Kabir Muhammad I. , Subhani Mahbube , MacLeod Alastair , Fehervari Andras , Hall Mitchell , Moulton Patrick
Published: March 2019

Prefabricated construction is an emerging industry in Australia and considered a key mechanism to boost productivity in the construction industry. The use of fibre reinforced concrete has a huge potential in the prefabricated industry as the concrete can be delivered straight to the precast mould, eliminating in many cases the steel reinforcement, thus increasing production quotas and cost savings. Such results can be further improved by utilising self-compacting concrete reinforced with fibres. Although the use of steel fibres as reinforcement is now well established, in the precast industry thin walls and shape of the moulds can be a limitation to steel fibre as well as work health and safety concerns for handling. Under such conditions, the use of polymeric fibres can be extremely beneficial, reducing labour hours and placement time as well as improving safety. This paper reports the development of high strength self-compacting fibre reinforced concrete for application in prefabricated concrete industry, exploring the effect of Forta-Ferro and ReoShore fibres on concrete fresh and mechanical properties.
Experimental Study on Bending Performance of Composite Sandwich Panel with New Mixed Core
Authors: Zhang Jing , Hu Xiamin , Hong Wan , Zhang Bing , Zhang Chengli
Published: March 2019

This paper presents an experimental investigation of bending performance of composite sandwich panels with new mixed core, sandwich panels were tested by four-point bending test. Parametric study was conducted to investigate the influence of different core materials on the failure mode, ultimate bearing capacity, stiffness and ductility of composite sandwich panels. The results of the experimental investigation showed that the mixed core can change the failure mode of sandwich panels. The failure mode of wooden panels is characterized by tensile failure of bottom wood, and the failure mode of composite sandwich panels with wood core is that the surface layer and core are stripped and the webs are damaged by shear, while the failure mode of composite sandwich panels with wood and polyurethane foam mixed core is the shear failure of the web. Composite sandwich panels with GFRP-wood-polyurethane foam core have better bending performance and can effectively reduce the weight of panels.
The effect of bermuda grass root morphology on the displacement of slope
Authors: JI Xiao-Lei , YANG Ping
Published: March 2019

During recent years, with the drastic development of highway, lots of slopes are produced which cause the increase of geological disasters including soil erosion on the slope and shallow sliding surface, it makes significant impact on the ecological environment. Adopting ecological protection technique of plant slope protection not only can prevent geological disasters, but also benefit the protection of ecological environment. In the paper, bermuda grass, as one kind of ordinary slope protection plants, was chosen as specimen, and the root-soil composite was regarded as organic system which consists of soil and root system; the effect of root morphology on displacement of slope surface under the function of rain erosion and slope runoff erosion was studied and analyzed by using nonlinearity finite calculation method. The result indicates Bermuda grass root system can defense the rain erosion of slope surface soil, restrain the soil displacement and prevent water and soil erosion of slope.
Preparation of SBS Modified Emulsified Asphalt in High Cold Region
Authors: Yanming HOU
Published: March 2019

A kind of SBS modified emulsified asphalt for highly cold area was studied by experiments. The research includes two aspects: the first is preparation of SBS modified asphalt. The influence of temperature, time, shear rate and development time on asphalt modification are determined, so as to determine the process of SBS modified asphalt. On this basis, the blending ratio of SBS modified emulsified asphalt was determined by experiments. The results show that the emulsified asphalt produced by the equipment is of good quality and good ductility.4%SBS latex content can make emulsified asphalt meet the standard requirements, but only 6%SBS latex content can obtain better road performance. Although the softening point of SBS modified emulsified asphalt prepared by this method is still low, it can meet the requirements of high cold area.
Staphylococcus-aureus-Blutstrominfektion – eine interdisziplinäre Herausforderung
Authors: Hagel Stefan , Kaasch Achim , Weis Sebastian , Seifert Harald , Pletz Mathias , Rieg Siegbert
Published: March 2019

Hintergrund Staphylococcus aureus ist der zweithäufigste Erreger von Blutstrominfektionen. Das klinische Management einer S.-aureus-Blutstrominfektion (SAB) unterscheidet sich von dem bei Blutstrominfektionen durch andere Erreger. Gründe hierfür sind der komplikationsträchtige Verlauf, die hohe Krankenhaussterblichkeit (15 – 40%) und das häufigere Auftreten von Rezidiven.

Methoden Es erfolgte eine selektive Literaturrecherche in PubMed. In die Analyse wurden die aktuellen Leitlinien- und Expertenempfehlungen einbezogen.

Ergebnis Der Nachweis von S. aureus in der Blutkultur sollte grundsätzlich als klinisch relevant betrachtet werden. Mittel der Wahl zur Therapie bei einer Blutstrominfektion mit Methicillin-sensiblen S. aureus ist Flucloxacillin (8 – 12 g i. v./d). Bei einer Blutstrominfektion mit Methicillin-resistenten S. aureus (MRSA) werden Vancomycin oder Daptomycin (letzteres nicht bei pneumogenem Fokus) empfohlen. Die Abnahme von Folgeblutkulturen, eine intensive Fokussuche einschließlich transösophagealer Echokardiografie bei Patienten mit Risikoprofil und eine rasche Fokussanierung sind wichtige Maßnahmen. Die Therapiedauer beträgt bei unkomplizierter SAB mindestens 14 Tage, wobei die gesamte Therapie intravenös durchgeführt werden soll. Bei komplizierter SAB wird eine Gesamttherapiedauer von mindestens 4 – 6 Wochen empfohlen. Durch Adhärenz an dieses Maßnahmenbündel kann die Sterblichkeit um bis zu 50% reduziert werden.

Schlussfolgerung Die SAB geht mit einer hohen Morbidität und Letalität einher. Das klinische Management ist komplex. Durch Einhaltung von diagnostischen und therapeutischen Maßnahmen kann die Prognose verbessert werden.
Dysphagie bei tracheotomierten Patienten nach Langzeitbeatmung
Authors: Heidler Maria-Dorothea
Published: March 2019

Unabhängig von der Art der kritischen Erkrankung haben tracheotomierte Patienten ein hohes Risiko, eine Schluckstörung zu entwickeln. Diese ist potenziell lebensbedrohlich, da sie zu Aspiration und Pneumonie führen kann. Vor einer oralen Nahrungsgabe sollte daher unbedingt eine Schluckdiagnostik mittels Bolusfärbetest und/oder FEES durchgeführt werden. Da ein physiologischer Luftstrom durch den Larynx und ein adäquater subglottischer Druck Schlüsselkomponenten eines effektiven Schluckaktes sind, sollte eine Oralisierung bei geblockter Trachealkanüle möglichst vermieden werden.
Eine videobasierte Analyse zur Klassifizierung von Schulterverletzungen während der Handball-Weltmeisterschaft 2015
Authors: Hansen Clint , Sanz Lopez Fernando , Whiteley Rodney , Wilhelm Andreas , Popovic Nebojsa , Ahmed Hosny , Cardinale Marco
Published: March 2019

Verletzungen spielen eine gravierende Rolle im Hochleistungssport und treten sowohl im Training als auch im Wettbewerb auf. Handball ist ein Mannschaftssport mit hohen physischen Anforderungen und die Messung spezifischer Belastungen hat das Potenzial, Risikofaktoren für Verletzungen zu identifizieren. Nur wenige Studien haben dies im Handball während einer Weltmeisterschaft getan. Das Ziel dieser Studie ist die Erfassung von Schulterverletzungen, die während der 88 Spiele der Männer-Weltmeisterschaft 2015 auftraten, und positionsspezifische Unterschiede zu erörtern. Spieler aus 24 Nationalmannschaften wurden mithilfe eines Kamerasystems und einer speziellen Software (Prozone Handball V. 1.2, Prozone, Leeds, UK) analysiert. Insgesamt wurden 9 Schulterverletzungen erfasst. Für 3 dieser 9 Verletzungen konnte keine Fremdeinwirkung dokumentiert werden. Die Anzahl der Pässe und Würfe ist von der Spielposition abhängig und die höchste diesbezügliche Belastung weisen Rückraumspieler auf. Die beiden Rückraumspieler, die eine Non-Kontaktverletzung erlitten, weisen im Vergleich eine erhöhte Spielzeit und eine erhöhte Anzahl an Würfen auf. Es scheint, dass es einen Zusammenhang zwischen erhöhter Spielzeit und Verletzungen gibt. Um das Risiko einer Verletzung zu senken sollte sowohl die Belastung gemessen (während des Trainings und des Turniers) als auch eine gezielte Verletzungsprävention durchgeführt werden, um die Spieler auf die Anforderungen des Spiels/Turniers vorzubereiten.
Advances in Delayed-Onset Muscle Soreness (DOMS) – Part II: Treatment and Prevention
Authors: Heiss Rafael , Lutter Christoph , Freiwald Jürgen , Hoppe Matthias , Grim Casper , Poettgen Klaus , Forst Raimund , Bloch Wilhelm , Hüttel Moritz , Hotfiel Thilo
Published: March 2019

Delayed-onset muscle soreness (DOMS) describes an entity of ultrastructural muscle damage. The manifestation of DOMS is caused by eccentric muscle contractions or unaccustomed forms of exercise. Clinical signs include impaired muscular force capacities, painful restriction of movement, stiffness, swelling, and altered biomechanics in adjacent joints. Although DOMS is categorised as a mild type of muscle damage, it is one of the most common reasons for compromised sportive performance. In the last decade, many hypotheses have been developed to explain the aetiology of DOMS, and there are a wide range of different interventions aiming to prevent or alleviate the symptoms. Many studies have evaluated various types of cold or heat therapy, compression, massage, physical therapy or nutritional interventions. Treatment considerations focus on the primary prevention of ultrastructural lesions during exercise, the treatment of the inflammatory response that leads to DOMS, and recovery strategies for manifest DOMS. This narrative review aims to present an overview of the current treatment and preventive strategies in the field of DOMS.
Labordiagnostik bei Kollagenosen und Vaskulitiden
Authors: Csernok Elena
Published: March 2019

Der Hauptanteil der immunologischen labormedizinischen Untersuchungen bei Kollagenosen und Vaskulitiden besteht -neben entzündungsdiagnostischen, hämatologischen, urinanalytischen, klinisch-chemischen, zytologischen und histologischen Untersuchungen - vor allem in der Bestimmung krankheitsassoziierter Autoantikörper. Grundstein der Labordiagnostik ist dabei der Nachweis von Antinukleären Antikörpern (ANA) bzw. Anti-Neutrophilen Cytoplasmatischen Antikörpern (ANCA). Der Nachweis dieser Autoantikörper unterstützt Diagnose-Sicherung oder -Ausschluss, Sub-Spezifizierung der Erkrankungs-Entitäten, Prognose und die Verlaufsbeobachtung. Der vorliegende Artikel über die Labordiagnostik dieser Erkrankungen hat deshalb die Beschreibung von Autoantikörpern und ihrer diagnostischen Bedeutung bei Kollagenosen und Vaskulitiden zum Schwerpunkt.
Das Antiphospholipidsyndrom
Authors: Rose Thomas , Dörner Thomas
Published: March 2019

Das Antiphospholipidsyndrom (APS) ist eine seltene Erkrankung, die klinisch mit thrombembolischen Ereignissen einhergeht und häufig verbunden ist mit Schwangerschaftskomplikationen. Die Antiphospholipid-Antikörper sind ein zentraler Bestandteil in der Pathogenese des APS und haben über den prokoagulatorischen Effekt hinaus Auswirkungen auf das Immunsystem. Der Nachweis der Antiphospholipid-Antikörper gilt bei Gesunden als Risiko für thrombembolische Ereignisse und die sogenannte Tripel-Positivität ist dabei mit einem besonders hohen Risiko für thrombembolische Ereignisse verbunden. Die Therapie des APS ist abhängig von der klinischen Konstellation und umfasst die Gabe von ASS und Vitamin-K-Antagonisten bzw. Heparin. Die direkten orale Antikoagulanzien sind zwar häufig im Label anwendbar, allerdings zeigt eine aktuelle Studie eine höhere Rezidivrate bei tripel-positiven APS-Patienten unter Rivaroxaban.
Herz nachts unter Druck
Authors: Hain Fabian
Published: March 2019

Herzrasen, Schweißausbrüche und Hypertonie. Diese Symptome lassen Patienten mit Schlafhypertonie mitten in der Nacht aus dem Schlaf hochschrecken. Die Ursache der Schlafhypertonie ist in der Regel eine diastolische Herzinsuffizienz verschiedener Genese, die einen erhöhten Innendruck zur Folge hat. Eine sinnvolle naturheilkundliche Therapieoption ist die Aderlasstherapie basierend auf der sogenannten Doppel-Hämatokrit-Analyse.
Noch ganz sauber?
Authors: Handke Denis
Published: March 2019

Regelungen zur Praxishygiene für Heilpraktiker finden sich im Infektionsschutzgesetz, in den Hygieneverordnungen der Länder, den KRINKO-Empfehlungen des Robert Koch-Instituts und vor allem in der TRBA 250. Zu den Basismaßnahmen zählen hygienische Handwaschplätze, Spender für Seife, Zellstofftücher und Desinfektionsmittel sowie eine fachgerechte Hände- und Flächendesinfektion. Alle Maßnahmen der Hygiene sind in einem Hygieneplan zu dokumentieren.
Präeklampsie und HELLP-Syndrom
Authors: Föhl-Kuse Sabine
Published: March 2019

Präeklampsie und HELLP-Syndrom gehören zu den gefährlichsten
Schwangerschaftskomplikationen, von denen jährlich 2–8 % aller Schwangeren
betroffen sind. Die Erkrankung gilt als multifaktoriell und noch immer die
Entbindung als die einzig wirksame Therapie. Diese Erkrankungen sind für etwa
ein Drittel der Frühgeburten verantwortlich.
Prävention von Anfang an
Authors: Lück Isabel , Bau Anne-Madeleine
Published: March 2019

Der Stoffwechsel eines Kindes wird schon im Mutterleib geprägt und das hat
entscheidenden Einfluss auf Körpergewicht und Gesundheitszustand – für das ganze
Leben. Ein gesundheitsfördernder Lebensstil in der Schwangerschaft und in den
ersten Lebensjahren (insbesondere in den ersten 1000 Tagen: von der Konzeption
bis zum 2. Geburtstag) ist daher von enormer Bedeutung. Diese Zusammenhänge
untersuchen immer mehr wissenschaftliche Studien.
Assisted Reproductive Technology and Epigenetics
Authors: DeAngelis Anthony , Martini Anne , Owen Carter
Published: March 2019

Assisted reproductive technology (ART) is responsible for 1.7% of births in the United States annually. Despite a large number of studies promoting the efficacy and safety of these practices, there have been reports of imprinting disorders occurring at higher frequencies in children born through ART. Driven by findings in animal studies, it has been postulated that various ART procedures employed at critical points in embryonic development may predispose the genomic imprinting process to errors. Alterations in DNA methylation patterns at imprinting control centers have been reported by some studies to occur more frequently in children with imprinting disorders conceived by ART compared with spontaneous conception, though these findings are not consistently demonstrated and controversy has surrounded the strength of these associations. The rarity of imprinting disorders with a reliance of studies on disease registry cohorts, wide variations in ART protocols, and a lack of proper control groups limit the ability to substantiate associations between imprinting disorders and ART. Large, prospective cohort studies with a focus on molecular etiologies of these conditions are needed to discern whether a true association exists. Based on current evidence, the absolute risk of imprinting disorders after ART is low and screening for imprinting disorders in children conceived by ART is not warranted.
Assisted Reproductive Technology and Origins of Disease: The Clinical Realities and Implications
Authors: Seli Emre , Morin Scott
Published: March 2019

The majority of offspring born following assisted reproductive technology (ART) achieve equivalent development milestones and demonstrate comparable health as spontaneously conceived children. Yet, multiple studies have suggested offspring conceived with ART have slightly increased risk of metabolic derangements, cardiovascular disease, and malignancy. However, the associations observed in these studies often inadequately control for a variety of confounding variables, such as multiple gestation, premature birth, and low birth weight. Furthermore, many studies fail to account for the increased risk of many of these pathologies in the offspring of subfertile women in general. Lastly, the absolute risk of most of the ailments studied is extremely low. In nearly all examples, the number of women who would need to be treated to observe one additional diagnosis is substantially high. When compared with the number of couples who would have remained childless due to severe male factor infertility or would have been exposed to the risk of passing on a severe monogenic disorder, the general increased risks to ART-exposed children is very small.
The Effectiveness of the Cold Therapy (cryotherapy) in the Management of Inflammatory Parameters after Removal of Mandibular Third Molars: A Meta-Analysis
Authors: Fernandes Ighor Andrade , Armond Anna Catharina Vieira , Falci Saulo Gabriel Moreira
Published: March 2019

Introduction Cold therapy (cryotherapy) is a common procedure recommended by dental surgeons after surgical removal of third molars, which is an invasive intervention that often deals with an expressive inflammatory response.

Objective To investigate whether cryotherapy interferes with clinical outcomes such as pain, edema, and trismus in the postoperative period of mandibular third molar surgeries.

Data Synthesis An electronic search was conducted in the OVID, PubMed, VHL, Science Direct, Cochrane Library, and Web of Science databases, through March 2018. The eligibility criteria included clinical trials that evaluated the effect of cryotherapy in at least one of the following variables: pain, swelling, and trismus.

Two independent reviewers assessed the studies. The methodological quality of each article was analyzed. The search strategy resulted in 1,088 articles. Following the selection process, 11 studies were included in the systematic review and 4 of them in the meta-analysis. High risk of bias was found in most of the studies according to the Cochrane Handbook assessment. Patients receiving cryotherapy had less edema than patients in the control group at second day follow-up (mean difference [MD]: -0.94; 95%CI [-1.49; -0.39]). There were no statistically significant results when comparing trismus between experimental and control group (MD: 0.43; 95%CI [-0.34;1.20]). There were insufficient available data to support influences in postoperative pain.

Conclusions Cryotherapy applied on the first day after mandibular third molar removal can manage edema in the patients. Well-designed randomized clinical trials to test the efficacy of cryotherapy after surgical removal of third molars are needed to justify its indication.
Comparison of Patient-Reported Outcomes of Total Hip Arthroplasty between a Neck-Preserving Short-Stem Implant and a Conventional Neck-Sacrificing Implant
Authors: Malanka Stefany J. K. , Dettmer Marius , Pourmoghaddam Amir , Veverka Mitchell , Kreuzer Stefan W.
Published: March 2019

Femoral neck-preserving short- (NPS) stem implants for total hip arthroplasty (THA) bear several advantages over longer-stem implants, such as native hip structure preservation and improved physiological loading. However, there still is a gap of knowledge regarding the potential benefits of a short-stem design over conventional neck-sacrificing stems in regards to patient-reported outcomes (PROs). The authors investigated the differences in PROs between a neck-sacrificing stem design and NPS stem design arthroplasty. They hypothesized that PROs of NPS stem THA would be higher in the medium-term in comparison to the neck-sacrificing implant system. Neck-sacrificing implant patients (n = 90, age 57 ± 7.9 years) and a matched (body mass index [BMI], age) cohort group of NPS implant patients (n = 105, age 55.2 ± 9.9 years) reported both preoperative and postoperative hip disability and osteoarthritis outcome scores (HOOS). Average follow-up was 413 ± 207 days (neck sacrificing implant) and 454 ± 226 days (NPS implant). The authors applied multivariate analysis of variance (MANOVA) and Mann–Whitney tests for statistical analyses. Significance levels were Holm–Bonferroni adjusted for multiple comparisons. HOOS Subscores increased significantly after surgery independent of implant type (p < 0.001). There was a significant time by surgery interaction (p = 0.02). Follow-up HOOS subscores were significantly higher in the NPS implant group: symptoms (p < 0.001), pain (p < 0.001), activities of daily living (ADL; p = 0.011), sports and recreation (p = 0.011), and quality of life (QOL; p = 0.007). While long-term studies are required for further investigation, evidence from the current study suggests that NPS implants may provide a significant benefit to primary THA patients, which could be due to physiological loading advantages or retention of bone tissue.
Benign Acute Childhood Myositis Associated with Influenza A (H1N1) Virus Infection: Evaluation of 22 Cases
Authors: Ağır Mehmet , Arslan Şükrü , Yorulmaz Alaaddin
Published: March 2019

We present the epidemiology, clinical features, and laboratory findings of 22 cases diagnosed with benign acute childhood myositis (BACM) after H1N1 infection in Konya, to observe and discuss this rare condition. This retrospective study was conducted in 22 children, diagnosed with BACM, who were brought to pediatric emergency department and pediatric rheumatology outpatient clinic of Selçuk University Medicine Faculty because of walking difficulties, between September 2017 and January 2018. Sixteen of the 22 (72.7%) patients enrolled in the study were male. The age of onset of symptoms ranged between 55 and 172 months. The interval between the onset of symptoms and the diagnosis was between 2 and 10 days. Throat pain was present in all cases as a prodromal symptom. Twelve (54.54%) of the cases presented with inability to stand or walk. Nine (40.90%) had gait abnormalities such as tip-toe walking, or a wide-based gait with a lordotic posture. Bilateral calf sensitivity was present in all cases. One patient had hypoactive deep tendon reflexes. In conclusion, although BACM is almost a typical clinical condition, we conclude that the recognition of the disease by family doctors and pediatricians is not sufficient and frequently underdiagnosed.
3D CFD wind flow analysis technique applied to a parabolic solar tracker for two extreme weather conditions with experimental results and a controller proposition
Authors: Huerta Chavez Oliver , Díaz Salgado Jorge , Ortiz Cil Chistrian , Jimenez Escalona Jose , Torres Cedillo Sergio , Cuamatzi Ruben
Published: March 2019

This work presents a Computational Fluid Dynamics (CFD) wind flow analysis technique applied to a Parabolic Solar Tracker (PST) using a three-dimensional Reynolds-Averaged Navier-Stokes Method. The modeling technique considered two extreme weather conditions named: (i) North Wind (NW) and (ii) Severe Convective Storms (SCSs), both of which can severely affect the integrity and the position control of a PST under operational conditions. The NW case simulated was validated using experimental data without bottom effects in order to verify the degree of approximation between the numerical results obtained in each approach and measurement data. It was observed that the simulated data were satisfactory in most cases, with predictions on the order of 77% compared to the measured data. The numerical CFD results at different heights for both cases, NW and SCS, were also verified. Finally, the CFD wind flow analysis technique results were used to: (i) establish both analytical and numerical models for dynamic and steady state analysis, control design, and simulation purposes and (ii) consequently design a closed loop controller which can minimize the wind effects.