bluuebunny/crossref_metadata_2025 huggingface dataset:
Revisiting regulatory decoherence: Accounting for temporal bias in a co-expression analysis reveals novel candidates controlling environmental response
Authors: Cai Haoran , Des Marais David
Published: January 2022

Transcriptional Regulatory Networks (TRNs) orchestrate the timing, magnitude, and rate of organismal response to many environmental perturbations. Regulatory interactions in TRNs are dynamic but exploiting temporal variation to understand gene regulation requires a careful appreciation of both molecular biology and confounders in statistical analysis. Seeking to exploit the abundance of RNASequencing data now available, many past studies have relied upon population-level statistics from cross-sectional studies, estimating gene co-expression interactions to capture transient changes of regulatory activity. We show that population-level co-expression exhibits biases when capturing transient changes of regulatory activity in rice plants responding to elevated temperature. An apparent cause of this bias is regulatory saturation, the observation that detectable co-variance between a regulator and its target may be low as their transcript abundances are induced. This phenomenon appears to be particularly acute for rapid onset environmental stressors. However, exploiting temporal correlations appears to be a reliable means to detect transient regulatory activity following rapid onset environmental perturbations such as temperature stress. Such temporal correlation may lose information along a more gradual-onset stressor (e.g., dehydration). We here show that rice plants exposed to a dehydration stress exhibit temporal structure of coexpression in their response that can not be unveiled by temporal correlation alone. Collectively, our results point to the need to account for the nuances of molecular interactions and the possibly confounding effects that these can introduce into conventional approaches to study transcriptome datasets.
The Employment in Innovative Enterprises in Europe
Authors: Laureti Lucio , Alberto Costantiello , Matarrese Marco Maria , Leogrande Angelo
Published: January 2022

In this article we evaluate the determinants of the Employment in Innovative Enterprises in Europe. We use data from the European Innovation Scoreboard of the European Commission for 36 countries in the period 2000-2019 with Panel Data with Fixed Effects, Panel Data with Random Effects, Dynamic Panel, WLS and Pooled OLS. We found that the “Employment in Innovative Enterprises in Europe” is positively associated with “Broadband Penetration in Europe”, “Foreign Controlled Enterprises Share of Value Added”, “Innovation Index”, “Medium and High-Tech Product Exports” and negatively associated to “Basic School Entrepreneurial Education and Training”, “International Co-Publications”, and “Marketing or Organizational Innovators”. Secondly, we perform a cluster analysis with the k-Means algorithm optimized with the Silhouette Coefficient and we found the presence of four different clusters. Finally, we perform a comparison among eight different machine learning algorithms to predict the level of “Employment in Innovative Enterprises” in Europe and we found that the Linear Regression is the best predictor.
Impact of ageing on female metabolic flexibility: a cross-sectional pilot study in over-60 active women
Authors: Monferrer-Marín Jordi , Roldán Ainoa , Monteagudo Pablo , Chulvi-Medrano Iván , Blasco-Lafarga Cristina
Published: January 2022

Background
Ageing influences the metabolic flexibility, albeit the physical status could determine this relationship. This cross-sectional study aims to describe and analyse the metabolic flexibility/inflexibility in a group of active older women, together with the impact of ageing and physical status on their oxidation rates and maximal fat oxidation (MFO).
Methods
Fifteen volunteers (69.00±6.97 years) from 24 women, completed an incremental cycling test until the second ventilatory threshold. Intensity increased 10W each 3min–15sec, starting at 30W. Gas exchange, heart rate, rate of perceived effort, pain scale and muscle power were registered, together with lactate. VO2 and VCO2 were considered for Fat and CHO oxidation (FATox & CHOox; Frayn’s equation) at the intensities 60%, 80% and 100% from the peak of power in the test (P100). Psychophysiological parameters were compared at MFO/FATmax and P100, together with the main correlation analyses, with and without P100 and VO2 as covariates.
Results
FATox was low at MFO (0.13; 95%CI [0.09-0.17] g·min−1·kg; 5.61 [3.59-7.63] g·min−1·kg FFM), with a shifting down and leftward of a short oxidation-rate curves. CHOox and FATox were both low for a reduced power with age (77.14±18.58 W & 39.29±9.17 W at P100 and MFO respectively), pointing to metabolic inflexibility in older women despite being active. Notwithstanding, the negative correlation between age and MFO (r=-0.54, p=0.04; R2=0.29) disappeared when normalized with P100 (r=-0.17, p=0.53), which was in turn strongly and negatively associated to age (r=-0.85, p<0.005; R2=0.72). P100 was also positive and moderately associated to MFO (r=0.71, p=0.01; R2=0.50).
Conclusions
Despite the inflexibility with age, physical status (i.e., larger muscular power) suggest a key role in the preservation of the metabolic health with aging in active women.
The complete genome sequences of Erythroxylum coca and Erythroxylum novogranatense
Authors: White Dawson , Meinhardt Lyndel , Bailey Bryan , Pirro Stacy
Published: January 2022

The flowering plant genus Erythroxylum contains approximately 300 species, including the economically and socially consequential crops called coca. We present the genome sequences of Erythroxylum coca and E. novogranatense, two cultigens produced for medicinal and quotidian use in the Andes and Amazon regions of South America, as well as the international cocaine industry. Sequencing was performed on an Illumina X-Ten platform, and reads were assembled by a de novo method followed by finishing via comparison with several species from the same genus. The BioProject, raw and assembled data can be accessed in GenBank for E. coca (PRJNA676123; JAJMLV000000000) and E. novogranatense (PRJNA675212; JAJKBF000000000)
Electronic gadgets use and sleep quality among medical students during COVID-19 Lockdown
Authors: Upreti Manish , Dawadi Ambika
Published: January 2022

BACKGROUND: The Nepal Government imposed two national-level lockdowns to curtail the spread of coronavirus. Schools, colleges, and universities were briefly shut leading students to stay indoors. Change in daily routine, online education and plenty of free time has ultimately led to an increase in use of electronic gadgets like smartphones, laptops, etc. There have not been enough studies to evaluate the usage pattern of electronic gadgets and sleep quality among undergraduate medical students of Nepal before and during the COVID-19 lockdown. Our study aims to evaluate the usage pattern of electronic gadgets and sleep quality among undergraduate medical students before and during the COVID-19 lockdown in Nepal.METHODOLOGY: This cross-sectional study was conducted among 208 undergraduate medical students of Lumbini Medical College, Tansen, Palpa. Participants were requested to fill up an online questionnaire circulated via Viber and Facebook messenger. Gadget usage pattern and sleep quality before and during COVID-19 lockdown were evaluated using Smartphone addiction score-short version (SAS-SV) and Pittsburgh Sleep Quality Index (PSQI) respectively.RESULTS: Of 208 responses which met the inclusion criteria, smartphone addiction was seen 94 (46.30%) respondents with higher number of male addicts (27.59%). Mean time spent in electronic gadgets raised significantly during lockdown compared to pre-COVID phase. 99 (48.77%) respondents had impaired sleep according to PSQI global sleep score. Significant relation was present between most of the components of PSQI with addicts and non-addicts.CONCLUSION: This study is merely a partial snapshot of the present scenario and provides preliminary understanding on smartphone use pattern and sleep quality among medical students from Nepal. It is critical to decrease total screen time and promote sleep quality for the betterment of physical and mental health of the future health care professionals.
Caregiver burden among family members of patients diagnosed with cancer in Jimma medical center oncology unit, south west Ethiopia.
Authors: Fufa Bikila Dereje , Bezabih Misgana Bezabih , Beyene Desalew Tilahun
Published: January 2022

Background

Cancer is a type of disease defined by uncontrolled growth and spread of abnormal cells, which can result in death. Globally, around 25 million people are surviving with it. The burden of cancer is growing in developing countries and it frequently comprises patient’s vitality. In addition, it has emotional, economical, physical and psychological burden on family, friends, significant others, community and other social resource.
Objective

To assess caregiver burden of cancer patients in Jimma medical center oncology unit, South west Ethiopia.
Method

An institutional based cross-sectional study design was employed. The study was done on 141 respondents using simple random sampling. A pretested semi structured interviewer administered questionnaire was used to collect the data. The collected data was entered in to EPI data version 3.1 then transferred to SPSS version 23 for data analysis. Multivariable logistic regression model was fitted, Adjusted Odds Ratio (AOR) at 95% confidence interval and p-value <0.05 were estimated to determine statistically association between predictors and outcome variables.
Results

The data were collected from the total of 141 respondents with 100% response rate. The mean ±SD age of cancer patients and care givers were 46.4 ±12.406 and 32 ± 11.23 years, respectively. The general level of caregiver burden in this study was mild to moderate (71.6%) with ZBI total score of 30 and by using CBI114 (80.9%) had some burden. Caregivers whose their age is greater than 40 years were 4.01 times more likely have high burden than those age between 20-40 old age [AOR=4.01, 95%CI (1.58, 10.17)].
Conclusion

The study disclosed a moderate level of caregiver burden among family caregivers.
Mapping Human Papillomavirus, Epstein-Barr Virus, Cytomegalovirus, Adenovirus, And P16 In Laryngeal Cancer
Authors: Schindele Alexandra , Holm Anna , Nylander Karin , Allard Annika , Olofsson Katarina
Published: January 2022

Purpose: Apart from tobacco and alcohol, viral infections are proposed as risk factors for laryngeal cancer. The occurrence of oncogenic viruses including human papilloma virus (HPV) and Epstein-Barr virus (EBV), in laryngeal squamous cell carcinoma (LSCC) varies in the world. Carcinogenesis is a multi-step process, and the role of viruses in LSCC progression has not been clarified. We aimed to analyze the presence and co-expression of HPV, EBV, human cytomegalovirus (HCMV) and human adenovirus (HAdV) in LSCC. We also investigated if p16 can act as surrogate marker for HPV in LSCC. Methods: Combined PCR/microarrays (PapilloCheck®) were used for detection and genotyping of HPV DNA, real time-PCR for EBV, HCMV and HAdV DNA detection, and EBER in situ hybridization (EBER-ISH) for EBV detection in tissue from 78 LSCC patients. Additionally, we analyzed p16 expression with immunohistochemistry.Results: Thirty-three percent (26/78) of LSCC tumor samples were EBV positive, 9% (7/78) HCMV positive and 4% (3/78) HAdV positive. Due to DNA fragmentation, 45 samples could not be analyzed with PapilloCheck®; 9% of the remaining (3/33) were high-risk HPV16 positive and also over-expressed p16. A total of 14% (11/78) of the samples over-expressed p16.Conclusion: These findings present a mapping of HPV, EBV, HCMV and HAdV, including the HPV surrogate marker p16, in LSCC in this cohort. Except for EBV, which was detected in a third of the samples, data show viral infection to be uncommon, and that p16 does not appear to be a specific surrogate marker for high-risk HPV infection in LSCC.
Improving the Efficiency of Photoelectronic Converters
Authors: Malko Natalie
Published: January 2022

The direction of work is the consideration of new principles of solar energy conversion, which involve solving such problems with solar cells as efficiency - what is: the level of efficiency, the high cost of structures associated with the use of rare elements, for example, such as indium and tellurium and mainly the need to use large areas.
Effects of nutritional intervention by feeding high-protein foods containing BCAA for improving locomotive syndrome: Randomized Controlled Trial
Authors: NAKAMURA YOSHIHIRO , FUNAMOTO TARO , TAJIMA TAKUYA , KIMURA HIROYUKI , HAMADA KOICHIRO , CHOSA ETSUO
Published: January 2022

[Purpose] Exercise guidance is an effective measure against locomotive syndrome. Appropriate nutritional management is also considered necessary in order to maintain the motor function. This study is the first exploratory and prospective research on the effects of exercise guidance and feeding high-protein foods in order to improve locomotive syndrome, in elderly people. [Method] We conducted a survey regarding five items related to locomotorium on the basic checklist prepared by the Japanese Ministry of Health, among men and women in their 60s and over living in Miyazaki Prefecture. Participation was solicited from those who responded “applicable” to three or more items, with those who gave their consent assigned to a food + exercise intervention group (EF group), an exercise intervention group (EX group), and a control group (C group) for research. Motor function surveys such as interviews, questionnaire, and locomotive syndrome risk test were conducted at the start of the study and three months later. The EX and EF groups were instructed to carry out locomotion training, while the EF group was asked to ingest one bag of high-protein test food daily immediately following exercise. The participants carried an activity meter and kept a record of their life in a diary during the study period. The EX and EF groups were encouraged to make recordings in a diary and carry an activity meter, while also getting a regular telephone contact once a week. [Results] An improvement in the motor function was observed in the EX and EF group compared to the C group via Locomotive syndrome risk testing. While the muscle mass decreased significantly during the study period in the C and EX group, no significant change was observed in limbs/trunk muscle mass in the EF group. [Conclusion] The locomotion training improved the results of the Locomotive syndrome risk testing. Although muscle mass decreased with exercise guidance alone, muscle mass loss was suppressed by feeding high-protein foods in addition to exercise. We conclude that feeding high-protein foods is useful for improving motor function and maintaining muscle mass, in addition to exercise guidance, as a measure against locomotive syndrome in elderly.
Uncovering the role of G9a modulatory landscape promoting neuronal plasticity and neuroprotection in Alzheimer's disease
Authors: Bellver-Sanchis Aina , Ávila-López Pedro , Companys-Alemany Júlia , Navarro Gemma , Marsal-García Laura , Larramona-Arcas Raquel , Miró Lluïsa , Pérez Anna , Ortuño-Sahagún Daniel , Choudhary Bhanwar , Soriano Francesc , Pallàs Mercè , Ferré Christian
Published: January 2022

Epigenetic alterations are a fundamental pathological hallmark of Alzheimer’s disease (AD). Herein, we uncover the unknown G9a modulation pathways involved in AD, showing the upregulation of G9a and H3K9me2 in the brains of AD patients. Likewise, treatment with a G9a inhibitor in SAMP8 mice reversed the high levels of H3K9me2 and rescued the cognitive decline. Interestingly, a transcriptional profile analysis revealed induction of neuronal plasticity and a reduction of oxidative stress and neuroinflammation; the latter being also validated in cell cultures. Furthermore, an exploratory H3K9me2 ChIP-seq analysis demonstrated that during G9a inhibition treatment, the H3K9me2 mark is enriched at the promoter of genes associated with neural functions. Lastly, we showed in Caenorhabditis elegans (C. elegans) AD transgenic strains, similar epigenetic modifications and modulated pathways were altered with increased β-amyloid levels, which were reverted by the set-25 (in C. elegans is similar to the mammalian G9a protein) knockout, including the cognitive impairment. Therefore, our findings confirm that RNAi suppression of set-25 or pharmacological G9a inhibition promotes a positive outcome in AD, being a promising therapeutic strategy.
Creating a Scientific Solution: Local Problem Solving in the Portuguese Health Examination Survey: A Mixed Method Study
Authors: Lyshol Heidi , Gil Ana Paula , Tolonen Hanna , Namorado Sónia , Kislaya Irina , Barreto Marta , Antunes Liliana , Gaio Vânia , Santos Ana João Carvalho da Silva , Rodrigues Ana P. Ambrosio , Dias Carlos
Published: January 2022

BackgroundParticipation rates in health surveys, recognized as an important quality dimension, have been declining over the years, which may affect representativeness and confidence in results. The Portuguese national health examination survey INSEF (2015) achieved a participation rate of 43.9%, which is in line with participation rates from other similar health examination surveys. The objective of this article is to describe strategies used by the local teams to increase participation rates and to solve practical survey problems.MethodsAfter a literature search, informal interviews were conducted with 14 public health officials from local health examination teams, regional and central authorities. 41 of the local staff members also filled in a short questionnaire anonymously. The interviews and self-administered questionnaires were analysed using mixed methods, informed by thematic analysis.ResultsThe local teams believed that the detailed manual, described as a "cookbook for making a health examination survey", made it possible to maintain high scientific standards while allowing for improvising solutions to problems in the local context. The quality of the manual, supported by a series of training workshops with the central research and support team, gave the teams the confidence and knowledge to implement local solutions. Motivation and cohesion within the local teams were among the goals of the training process. Local teams felt empowered by being given large responsibilities and worked hard to incite people to attend the examination through a close and persuasive approach.Local teams praised their INSA contacts for being available for assistance throughout the survey, and said they were inspired to try harder to reach participants to please their contacts for interpersonal reasons.ConclusionsThe theory of organizational improvisation or bricolage, which means using limited resources to solve problems, was useful to discuss and understand what took place during INSEF.A detailed manual covering standard procedures, continuous monitoring of the data collection and face-to-face workshops, including role-play, were vital to assure high scientific standards and high participation rates in this health examination survey. Close contacts between the central team and local focal points in all regions and all survey sites were key to accommodating unexpected challenges and innovative solutions.
Primary Cement Debris After Total Knee Arthroplasty
Authors: Yadav Ajit , Manohar Mithun , R Kesavan A
Published: January 2022

Polyethylene wear is accelerated by third body cement debris and contributes to aseptic loosening after knee arthroplasty. Saline irrigation with pulse lavage is expected to render the joint free of such particles. The purpose of this study is to qualitatively characterize such primary cement debris remaining in the knee joint after cemented total knee arthroplasty and briefly discuss ways to decrease it further.
Integration of Systematic Screening for Tuberculosis in Outpatient Departments of Urban Primary Health-Care Facilities in Zambia: A Case Study of Kitwe District
Authors: Zulu Davy Wadula , Silumbwe Adam , Maritim Patricia , Zulu Joseph Mumba
Published: January 2022

Background

Tuberculosis (TB) is the leading cause of death from a single infectious agent globally, yet 3 million cases are missed every year. The World Health Organization recommends systematic screening of suspected active TB patients among those visiting the healthcare facilities. While many countries have scaled-up systematic screening of TB, there has been limited assessment of the extent of its integration into the health system. This study sought to explore factors that shaped the integration of systematic screening of TB in outpatient departments of primary healthcare facilities in Kitwe district, Zambia.
Methods

This was a qualitative case study with health providers including district managers, TB focal point persons and laboratory personnel working in six purposively selected primary healthcare facilities. Data was collected through key informant (n=8) and in-depth (n=15) interviews. Data analysis was conducted using QDA Miner software and guided by Atun’s Integration framework.
Results

Integration was facilitated by perceptions of the magnitude of the TB burden, alignment of the intervention with national TB aspirations, knowledge of stakeholder interests, power and values, regular performance management and intra-facility collaboration. Constraining factors included external partners’ influence in the TB screening program, unbalanced incentivization mechanisms, donor-driven financing and social determinants of health such as gender and stigma including the COVID-19 pandemic.
Conclusion

Systematic screening of TB is not well integrated into the primary healthcare facilities to capture all those suspected with active TB that make contact with the health system. Finding the missing TB cases will, therefore, require contextual adaptation of the systematic screening for TB and strengthening the health system.
Impedance Flow Cytometry for Selection of Pollen Traits Under High Temperature Stress in Pepper
Authors: Lin Shih-wen , Lin Tsung-han , Yee Cynthia Kung Man , Chen Joyce , Wang Yen-wei , Nalla Manoj Kumar , Barchenger Derek W.
Published: January 2022

High temperature stress is a major limiting factor for pepper productivity, which will continue to be a problem under climate change scenarios. Developing heat tolerant cultivars is critical for sustained pepper production, especially in tropical and subtropical regions. In fruiting crops, like pepper, reproductive tissues, especially pollen, are the most sensitive to high temperature stress. Typically, pollen viability and germination are assessed through staining and microscopy, which is tedious and potentially inaccurate. To increase efficiency in assessing pollen traits of pepper, the use of impedance flow cytometry (IFC) has been proposed. We conducted three independent experiments to determine the most effective methodology to use IFC for evaluating pollen traits for heat tolerance in pepper. Seven floral developmental stages were evaluated, and stages 3, 4, and 5 were found to best combine high pollen concentration and activity. Flowers in development stages 3, 4, or 5 were then heat treated at 41, 44, 47, 50, and 55 °C or not heat treated (control). The critical temperature to assess heat tolerance using IFC was found to be 50 °C, with a reduction in pollen activity and concentration occurring at temperatures greater than 47 °C. Twenty-one entries of pepper were then accessed for pollen traits using the staining and IFC methods over 2 months, April (cooler) and June (hotter). Growing environment was found to be the greatest contributor to variability for nearly all pollen traits assessed, with performance during June nearly always being lower. PBC 507 and PBC 831 were identified as being new sources of heat tolerance, based on using IFC for assessing pollen. Pollen viability determined by staining and pollen activity determined using IFC were significantly positively correlated, indicating that IFC is an efficient and accurate method to assess pollen traits in pepper. This work provides a basis for further research in this area and supports more efficient breeding of heat-tolerant cultivars.
Thai and Serbian Student L2 Motivational Selves: A Contrastive Study
Authors: Topalov Jagoda , Radić Bojanić Biljana
Published: January 2022

Applying L2 Motivational Self-System, the aim of this paper is to investigate how Thai and Serbian students construct their L2 motivational self-systems. A total of 543 students from Thailand and Serbia completed an 18-item questionnaire aimed at sampling relevant motivational factors. Although the students from both universities reported medium levels of motivated behaviour and a strong influence of their L2 learning experience, the most influential factors in the construction of self-systems were fundamentally different. While Serbian students construct their motivational self-systems on the basis of their ideal L2 selves, Thai students shape their motivational self-systems on the basis of ought-to L2 self. This difference points to the overall teaching approaches adopted in the investigated settings, where in Serbia learning experience is guided by the communicative approach to language teaching, while the Thai learning experience rests on a teacher-centred approach shaped by the collectivist cultural orientation.
"Heritage-for-Peace and Development": An Opportunity Not to be Missed
Authors: Milenković Miloš
Published: January 2022

The dominant approach of the international community to the subject of our research and teaching is to instrumentalise cultural heritage safeguarding within stabilisation and development programs in post-conflict regions. Since the turn of the Millennium, cultural heritage safeguarding has been among the crucial instruments used by the international community, especially in post-conflict regions, for: reconciliation and peace building; development of a common sense of belonging; promoting mutually respectful dialogue in culturally complex societies. Many international organizations, such as the UN, the OSCE High Commissioner on National Minorities, NATO, the Stability Pact for South Eastern Europe, the World Bank, the United Nations Development Program, the Council of Europe, and the EU, promote the management of ethno-political conflicts as their priority. Their agendas follow the principles of a) the overall relevance of cultural heritage for society and b) the importance of social networks for peace-building and peacekeeping in post-traumatic contexts. Instead of opposing this peace and development oriented paradigm from either anti-realist or nationalist perspective, we can recognize it, apply it and use it to improve the social status of social sciences and humanities in Serbia. Anthropological and critical heritage studies-based criticism of UNESCO-driven, state-governed ICH safeguarding fails to comprehend that standard academic constructivist analyses of a community’s key symbols of identity are offensive from the native’s point of view. Our typical analyses unwittingly confuse, annoy or even insult a great majority of the wider public who view/perceive collective identity as something given, inherited and real analogously to the objects and processes of the physical world. Consequently, our theoretical work counterindicates both peacekeeping, stability-building efforts by the international community in post-conflict regions and the goals of critical social science (which it nominally represents). Hence, a novel approach is required, one prioritising heritage stakeholder inclusion (and not our theoretical or ethnoreligious commitments). It is precisely the studies of nationalism and its consequences which forbid us to think of heritage as something useful, a counter-intuitive method for achieving fundamental anthropological goals. As communities regularly perceive their identities as objective and real, and see a critical social theory approach to their customs and traditions as confusing, non-academic, illegitimate or even offensive, I here propose a shift from constructionist criticism, standard in anthropology, to realist instrumentalism, typical of ethnology, in order to boost ICH safeguarding potential for achievement of both social and disciplinary-specific goals.
Municipal Waste Management in Poland Compared to Other European Union Countries
Authors: Poniatowska Agnieszka , Kisiel Monika , Panasiuk Damian
Published: January 2022

The paper discusses the current state of municipal waste management in Poland compared to other European Union countries. It indicates the amounts of municipal waste generated over the last few years in Poland and other EU countries. The paper compares waste treatment methods in Poland and Europe, such as recycling, composting, thermal treatment and waste disposal. An analysis of municipal waste processing installations in Poland is presented. The trends in the municipal waste management system in recent years have also been described. In the field of municipal waste management in Poland, there have been significant changes. The amount of waste sent to landfills has decreased, and the amount of waste recovered and recycled has increased. These changes are positive and reflect the development of municipal waste management systems in other EU countries. The article indicates the problems and directions of changes in the field of municipal waste management in Poland in the coming years, especially in the context of the implementation of circular economy assumptions and the goals set by the European Union in terms of increase the level of waste recycling and reducing their disposal.
Eğitim Düzeyi Yüksek Suriyelilerin Sosyo-Ekonomik ve Kültürel Sorunlarının Toplumsal Kabul ve Uyum Açısından Değerlendirilmesi: Kayseri Örneği
Authors: Şatıroğlu Güldalı Pelin , Özmen Zehni
Published: January 2022

Bu çalışmanın amacı geçici korumanın eğitim düzeyi yüksek Suriyeliler için anlamını, onların göç sürecini nasıl deneyimlediklerini ve bu süreçte yaşadıkları sorunları anlamaktır. Savaş nedeniyle Türkiye’ye göç etmek zorunda kalan Suriyeliler kendi içlerinde farklı dil, din, etnik kimlik, inanç ve kültüre sahip olmalarıyla birlikte farklı eğitim düzeyi, mesleki donanım ve becerilere sahiplerdir. Bu bağlamda eğitim düzeyi yüksek Suriyelilerin farklı ihtiyaç ve beklentilere sahip, göç sürecini farklı deneyimleyen bir grup olduğu ifade edilebilir. Göç sürecinde eğitim durumu ve çeşitli mesleki becerilerin göç edilen ülkeye aktarılması kaynak ülke ve hedef ülke arasındaki siyasi ilişkiler ve göç edilen ülke politikaları ile bağlantılıdır. Birçok göçmen aldıkları eğitim ve mesleki donanımlarından farklı olarak genellikle emek yoğun ve düşük ücretli işlerde çalışmak zorunda kalmaktadırlar. Bu anlamda Türkiye’ye göç etmek zorunda kalan eğitim düzeyi yüksek Suriyelilerin yaşadıkları sorunları anlamanın, hem farklı kültürlerle birlikte yaşama pratiği açısından hem de gelecekte eğitim düzeyi yüksek Suriyelilerle ilgili göç alanında yapılabilecek çalışmalar için literatüre katkı sağlaması açısından önemli olduğu düşünülmektedir.
Ag-TiO2 Nanoparticles-catalyzed Three-component Synthesis of 12-aryl-
8,9,10,12-tetrahydrobenzo[a]-Xanthen-11-ones in Aqueous Medium
Authors: Vahdat Seyed Mohammad , Omran Mahsa Lotfi , Barforosh Farhosh Kiani
Published: January 2022

Background:

Ag-TiO2 nanoparticles catalyzed synthesis of 12-aryl-8,9,10,12-
tetrahydrobenzo[a]-xanthen-11-ones have been enhanced via a three-component one-pot reaction
betweenβ-naphthol, several aldehydes and dimedone in H2O at room temperature. Xanthenes are
essential intermediates in chemistry owing to their vast difference in biological activity.

Methods:

This process offered significant advantages containing appropriate cost efficiency, low
amount of the catalyst, application of low-cost available Ag-TiO2 nanoparticles catalyst, purification
of the product by non-chromatographic method, easy process, good atom economy, simple
isolation and reusability of nanocatalyst.

Result:

Ag-TiO2 nanoparticles catalyst shows easy access to Xanthenes with appropriate yields in
short reaction time and purity. This nanoparticles catalyst was recycled and recovered by easy filtration
and was reused up to five times with only an unimportant loss in its catalytic efficacy.

Conclusion:

This method achieves to have a numerous scope relating to the difference in the aldehydes.
Correspondingly, the attractiveness of this research was that H2O was the only by-product.
Imidazole: Multi-targeted Therapeutic Leads for the Management of
Alzheimer’s Disease
Authors: Dhingra Ashwani K. , Chopra Bhawna , Jain Akash , Chaudhary Jasmine
Published: January 2022

Background:

Alzheimer's disease (AD) is a multifactorial disorder coupled with an array
of neuropathological mechanisms, including tau phosphorylation, Aβ aggregation, metal ion deregulation,
and oxidative stress, along with neuro-inflammation. The clinically available drugs for the management
of AD include four acetylcholinesterase inhibitors and one glutamatergic antagonist. These
agents provide only temporary relief from the symptoms by altering the neurotransmitter level in the
brain.

Objective:

Keeping in view the focus on research, the numerous pharmacological activities associated
with the aromatic diazole heterocyclic nucleus, imidazole, triggered the medicinal chemist to develop
a large number of novel anti-AD compounds targeting multiple pathological mechanisms associated
with AD. These prepared analogs represent a higher potential against neurological disorders, including
AD. This review article aims an ornately pronounce the therapeutic voyage of imidazole and its
analogs as anti-AD.

Methods:

It emphasizes the synthesized imidazole derivatives as anti-AD with multiple targets reviewed
from the data available on Pubmed.

Results:

These compounds diminish the pathophysiological aspects of AD; still, further studies are
required to prove the safety and efficacy of these compounds in humans.

Conclusion:

The review aims to provide knowledge and highlight the status of this moiety in the design
and development of novel drug candidates against Alzheimer’s disease conditions. Thus, it paves
the way for further work.
An Efficient Protocol for the Synthesis of new Camphor Pyrimidine and Camphor
Thiazole Derivatives using Conventional and Microwave Irradiation Techniques and In
vitro Evaluation as Potential Antimicrobial Agents
Authors: Abo-Bakr Ahmed M. , Hassan Entesar A. , Zayed Salem E. , Mahdy Al-Hassan S.
Published: January 2022

Background:

A series of new pyrimidines and thiazoles containing camphor moiety were synthesized under both conventional and microwave irradiation techniques.

Methods:

The condensation of camphor either with aminoguanidine or thiosemicarbazide gives the camphor hydrazine carboximidiamide 2 and the camphor thiosemicarbazone 3, respectively. Refluxing of 3 with chloroacetonitrile afforded the camphor thiazol-4-imine 4. Compounds 2 and 4 were used as precursors for the synthesis of target products.

Results:

The reaction of 2 with different species such as arylidene malononitrile, acetylacetone, and ethyl acetoacetate gave the corresponding camphor pyrimidine derivatives 5a,b-7 while refluxing of compound 4 with different reagents e.g. aldehydes, isatin, ninhydrin, acetic anhydride, benzene sulphonyl chloride, and p-nitro-benzoyl chloride afforded the camphor thiazole derivatives 8a-d-13, respectively.

Conclusion:

A comparison between the conventional and the eco-friendly microwave irradiation methods occurred during the synthesis of the same compounds, and the latter proved to be more efficient. The elemental analysis, FT-IR, 1H NMR, 13C NMR, and Mass spectra confirm the structures of the obtained new compounds. The potential use of some selected derivatives as antimicrobial agents was investigated and gave promising results.
Review on Acrylamide: A Hidden Hazard in Fried Carbohydrate-rich
Food
Authors: Iyer Aditya Manivannan , Dadlani Vedika , Pawar Harshal Ashok
Published: January 2022

Acrylamide is classified as a hazard whose formation in carbohydrate-rich food
cooked at a high temperature has created much interest in the scientific community. The review
attempts to comprehend the chemistry and mechanisms of formation of acrylamide and its levels
in popular foods. A detailed study of the toxicokinetics and biochemistry, carcinogenicity,
neurotoxicity, genotoxicity, interaction with biomolecules, and its effects on reproductive
health has been presented. The review outlines the various novel and low-cost conventional as
well as newer analytical techniques for the detection of acrylamide in foods with the maximum
permissible limits. Various effective approaches that can be undertaken in industries and
households for the mitigation of levels of acrylamide in foods have also been discussed. This
review will assist in providing an in-depth understanding of acrylamide that will make it simpler
to assess the risk to human health from the consumption of foods containing low amounts
of acrylamide.
"O evangelho segundo Jesus a rainha do céu": O expurgo social da mulher travesti através de uma decisão judicial
Authors: Ferreira Glenda , Colares Virgínia
Published: January 2022

This article examines a court decision issued by judge Roberto da SilvaMaia of the Pernambuco Court of Justice (TJPE). It applies Norman Fairclough’sCritical Discourse Analysis (CDA), the modes of operation of ideology of John B.Thompson and the Appraisal system developed by Jim Martin & Peter White. Wewill apply these tools in a form adapted to Brazilian Portuguese by Orlando VianJr. Our aim is to identify if there is, in the decision, an attempt to socially purge thetransvestite woman. After the analysis, we reflect on the social context in whichfreedom of artistic expression has caused discomfort and how the arguments usedto limit it reinforce the exclusion of and prejudice against transvestite women.
The image of the enemy in textbooks on the history of the USSR in the 1930s
Authors: BEZPALKO Bohdan
Published: January 2022

The article examines the peculiarities of the formation of the image of the enemy in the textbook of Andrei Shestakov "A Short Course in the History of the USSR." Also, the historiography of the issue is analyzed. It applies to both the Soviet era and the present. Despite the modest attention to this topic by foreign experts, the works that directly affect the issue are highlighted. The main changes in the then system of school education, which led to its unification and formed the requirements for the history lesson in general and the need to develop a textbook in particular, are outlined. The role of Andrei Shestakov, who was one of the first to develop an "ideal" history textbook for the Soviet government, is revealed. His career growth and work with Marxist-Leninist ideology are shown, which in turn helped to achieve this goal.The process of modification of negative connotations concerning those forces against which the Bolsheviks fought is traced. Thus considering the period of ancient history, the author criticized rich people. The negative image deepened when it came to religion in the Middle Ages. Priests and monks, compared to the wealthy, were perceived not as something "foreign" but more negative as something "hostile." Wealthy peasants received a special color, the term "kulaks" was used for them. The closer A. Shestakov approached the twentieth century in his presentation of historical material, the clearer the formation of the image of the enemy, not only internal but also external. Thus, the first was personified by all the forces against which the Bolsheviks fought. To define such "enemies" used the definition - "counter-revolutionary". The second category was represented by the Entente and the Nazis, who came to power primarily in Germany and Italy.
Dependencia financiera de las haciendas públicas en México, 2004-2016
Authors: García Galindo Juan Carlos
Published: January 2022

La descentralización fiscal implica problemas asociados a los principios de subsidiariedad y correspondencia fiscal, por lo que se plantea el estudio de la dependencia financiera como una situación estructural del actual Sistema Nacional de Coordinación Fiscal y sus incentivos de distribución de recursos federalizados. Para el análisis se adopta una concepción neoinstitucionalista del Estado aplicada a un gobierno federal. Se contextualiza la situación de las haciendas públicas subnacionales para determinar un Índice Estatal de Dependencia Financiera y se propone una modernización institucional para la transición hacia un federalismo hacendario, donde se incluyan en la agenda los temas de pasivos contingentes, fortalecimiento administrativo y la creación de una plataforma nacional de datos hacendarios, asimismo se exhorta a una Segunda Convención Nacional Hacendaria para replantear los mecanismos de distribución.
OAFA: THE PLACE UNDER THE SKY OF THE ANDES THAT HOUSES THE MASTER
Authors: Podestá R. C. , Lipunov V. M. , Podestá F. M. , Quinteros J. , Pacheco A. M. , González E. P. A. , Francile C. N. , Pérez J. , Marmolejo L. , Sedeño J. , Navarro J. , De La Jara F. , Rivero V.
Published: January 2022

This paper shows the infrastructure and discoveries made by Russian instruments installed in the Carlos U. Cesco high altitude station.
Color-Based Feature Extraction Method for Skin Segmentation Based on SVM
Authors: B. K. Harsha
Published: January 2022

Abstract: Different colored digital images can be represented in a variety of color spaces. Red-Green-Blue is the most commonly used color space. That can be transformed into Luminance, Blue difference, Red difference. These color pixels' defined features provide strong information about whether they belong to human skin or not. A novel color-based feature extraction method is proposed in this paper, which makes use of both red, green, blue, luminance, hue, and saturation information. The proposed method is used on an image database that contains people of various ages, races, and genders. The obtained features are used to segment the human skin using the Support-Vector- Machine algorithm, and the promising performance results of 89.86% accuracy are then compared to the most commonly used methods in the literature. Keywords: Skin segmentation, SVM, feature extraction, digital images
Ransomware Attacks in History of Cyber World
Authors: Zafri Fizza
Published: January 2022

Abstract: Technology advancement since last few decades creates cyber attack a critical issue. Cyber security has become an important part today. It has also become an important and crucial subject in the field of forensic science. Increased in the growth of internet technology and internet devices have increased the risk of cyber attack. Almost every organization today are depends on the internet and devices. There are many types of cyber attack. This paper is the detailed review about Ransomware attack. This paper is consisted about vast of the information about What is Ransomware Attack, how does it work, how ransomware attack emerged. After reading this paper you will learn about the ransomware attacks in history of cyber world. This will help you to learn and understand about ransomware attack, how to prevent yourself from ransomware attack. As a forensic science student, it is always important to be aware about the attacks that have happened in the history of cyber world. Before writing this paper, I have read and analyze many research paper and internet articles, so that I can write a detailed review paper which can help students and for the forensic awareness. Keywords: Cyberattack, Hacking, Ransomware, cyberworld, cyber security, ransomware, forensic, network security
Pengaruh servant leadership terhadap quality of work life pada karyawan generasi milenial
Authors: Ardiyanti Baiq Widya Ayu , Hasanati Nida , Prabowo Adhyatman
Published: January 2022

Indonesia is entering a demographic surplus era where millennial generation employees occupy most of the existing work opportunities. When the organization pays attention to and fulfills the needs of millennial generation employees, this arguably will prosper the employees so that their quality of work life can be realized. Organizational support provided by leaders who try to prioritize common interests over personal interests or servant leadership is one of the things that creates employees’ welfare because the employees’ needs are met. The purpose of this study was to determine the effect of servant leadership on the quality of work life of millennial generation employees. This study used quantitative methods with the sampling technique employed is using total sampling with the number of subjects in this are 96 people at BUMN X in West Nusa Tenggara. The data collection method used the servant leadership scale of 18 items and the quality of work life scale of 34 items. Data analysis used the simple linear regression technique. The results showed that there was a significant positive effect of servant leadership on the quality of work life. Servant leadership has an effect of 48.6% on the quality of work life for millennial generation employees (F = 88.893, p = 0.000, = 0.486).
Studi deskriptif minat sosial pada remaja ditinjau dari latar belakang keluarga
Authors: Syarqi Hultia Manani , Amalia Sofa
Published: January 2022

Today’s teenagers spend more time with technology than interacting with people around them whereas adolescents should experience the process of learning and exploring and developing themselves through their surroundings and social environment to foster social interests. The purpose of this study is to describe the social interest of adolescents, especially regarding the family background using quantitative and qualitative approaches. The number of subjects in this study was 196 people with the criteria of the age is those in the age of 12-18 years. Data collection is conducted using the Social Interest Index (SII) instrument by Greever with a total of 32 items. The results of the study show that adolescents have moderate level social interest. There is no significant difference between social interest and the characteristics of the subjects or their family backgrounds.
Dinamika psikologis fangirl k-pop
Authors: Almaida Risa , Gumelar Sandy Agum , Laksmiwati Adinda Azmi
Published: January 2022

The aim of this research is to exploring the psychology dynamics of K-Pop fangirl. Data were analyzed through descriptive qualitative method which obtained through interview. Subject selected based on purposive sampling method. The result showed that: a) Fangirls idolize K-Pop because of Idol music and Idol visual aspects. b) The three subjects are in Intense personal feeling level of Celebrity worshipping behavior. Each of them also feels like have an emotional attachment towards their idol. c) One of the subjects seems like have a sense of owning them (Bias is mine behavior). Subject thinks that every idol who has a romantic relationship towards another girl same as they betray their fans. d) There is also fujoshi behavior (in Japanese) in one of the subjects, a term of women who does like romantic interaction between same-sex (Bromance).
Pengaruh regulasi emosi kognitif terhadap depresi pada mahasiswa tingkat akhir dimasa pandemi covid-19
Authors: Maslita Vira Qoyyum , Saraswati Putri , Hijrianti Udi Rosida
Published: January 2022

The COVID-19 pandemic has affected people’s mental health, especially in the education sector. One of the mental health problems that often occur in students who are completing their final assignments are symptoms of depression. Cognitive emotion regulation is one capacity to overcome depression with the use of adaptive approach. The purpose of this study was to determine the effect of cognitive emotion regulation on depression in final year students in Indonesia during the covid-19 pandemic. This study uses a quantitative approach. The research subjects were 349 final year students and their data were taken using an accidental sampling technique. Analysis of research data used the simple linear regression test. The results showed that there was a significant influence between cognitive emotion regulation and depression (p = 0.00). The effect of cognitive emotion regulation shown is 4.2% of the variance of depression.
 
Keywords: Cognitive emotion regulation, college students, covid-19, depression, final assignment