bluuebunny/crossref_metadata_2025 huggingface dataset:
INDICADORES E RESULTADOS DA INTERVENÇÃO PRIMÁRIA NO INFARTO AGUDO DO MIOCÁRDIO COM SUPRADESNÍVEL DO SEGMENTO ST E ESTRATÉGIAS DE REVASCULARIZAÇÃO NO PACIENTE MULTIARTERIAL
Authors: Staico Rodolfo , Almeida de Sousa José Marconi , Kreimer Sergio ,   Rede D'Or.  São Paulo, SP, Brasil, Oliveira Breno ,   Hospital Israelita Albert Einstein.  São Paulo, SP, Brasil, Correa Pivatelli Flavio ,   Hospital da Associação Beneficencia Portuguesa de São José do Rio Preto. São José do Rio Preto, SP, Brasil
Published: January 2025

O infarto agudo do miocárdio com supradesnível do segmento ST (IAMCSST) tem prevalência elevada e constitui emergência médica devido ao risco iminente de eventos adversos. Os progressos nas intervenções coronárias percutâneas (ICP), incluindo stents farmacológicos mais seguros e eficientes, melhorias nas técnicas de implante e terapia coadjuvante mais potente, tornaram a intervenção coronária percutânea primária (ICPP) a estratégia padrão-ouro para o tratamento do IAMCSST, contribuindo para o declínio acentuado da mortalidade. O tempo porta-balão (TPB), definido como o intervalo de tempo entre a chegada no hospital e a restauração do fluxo coronário por meio da ICPP, emergiu como um indicador de qualidade. O tempo sintomas-balão (TSB), definido como o intervalo de tempo entre o início dos sintomas e a restauração do fluxo coronário por meio da ICPP, surgiu como um preditor confiável de mortalidade. Ações implementadas tiveram o objetivo de reduzir o TSB e consequentemente mitigar desfechos desfavoráveis. Entretanto, a mortalidade hospitalar global continua sendo um grande desafio. Igualmente, a ocorrência de insuficiência cardíaca após IAMCSST impacta significativamente a sobrevida e a qualidade de vida no longo prazo, afetando os sistemas de saúde. Há recomendação formal de angiografia imediata de rotina seguida de ICPP no IAMCSST dentro de 12h do início dos sintomas e naqueles pacientes com apresentação mais tardia, porém com sintomas persistentes e/ou instabilidade hemodinâmica/elétrica. O benefício da ICPP entre 12-48h mesmo sem sintomas persistentes de isquemia é corroborado por taxas mais baixas de morte hospitalar e reinfarto, em comparação com uma estratégia conservadora
Transforming enterprise systems with performance engineering excellence
Authors: Sudhakar Reddy Narra
Published: January 2025

This article explores the transformation of enterprise systems through advanced performance engineering methodologies and strategies. It examines how Fortune 500 enterprises have revolutionized their system performance by implementing sophisticated performance engineering practices across various domains. The article investigates the challenges faced by modern enterprise applications in distributed environments, including latency issues, resource allocation inefficiencies, and workload unpredictability. Through comprehensive analysis of real-world implementations, the article demonstrates how organizations have achieved significant improvements in operational efficiency, customer satisfaction, and system reliability through strategic performance engineering initiatives. The article covers various aspects including cloud-native architectures, shift-left testing practices, and the establishment of performance-oriented organizational cultures, providing insights into best practices and measurable business impacts of performance engineering excellence.
AI-Driven Transport and Distribution Optimization Model (TDOM) for the downstream petroleum sector: enhancing sme supply chains and sustainability
Authors: Chuka Anthony Arinze  , Mercy Odochi Agho  , Nsisong Louis Eyo-Udo  , Anate Benoit Nicaise Abbey  , Ekene Cynthia Onukwulu
Published: January 2025

The downstream petroleum sector faces significant challenges in transport and distribution logistics, particularly for small and medium enterprises (SMEs) that rely on efficient supply chains to remain competitive. Inefficiencies such as fluctuating demand, fuel shortages, and route optimization hurdles contribute to increased operational costs and environmental impact. Addressing these persistent issues requires innovative solutions that balance efficiency, cost reduction, and sustainability. This study introduces the AI-Driven Transport and Distribution Optimization Model (TDOM), a transformative approach designed to revolutionize logistics in the downstream petroleum sector. TDOM leverages advanced machine learning algorithms and predictive analytics to optimize delivery routes, reduce fuel consumption, and ensure real-time adaptability to market demands. By integrating data from diverse sources, including traffic patterns, fuel station inventories, and weather conditions, TDOM provides SMEs with actionable insights for enhanced decision-making. The primary objectives of this research are threefold: to improve supply chain efficiency for SMEs in the downstream petroleum sector, to minimize environmental impacts through reduced carbon emissions, and to ensure cost-effective transport and distribution processes. The methodology includes developing a robust AI-driven model utilizing supervised and unsupervised learning techniques, followed by simulation testing on real-world logistics data. Key performance metrics such as delivery time, cost savings, and carbon footprint reduction will be analyzed to validate the model's efficacy. Anticipated outcomes of the TDOM implementation include a 20-30% reduction in transport costs, a significant decrease in fuel consumption, and improved supply chain resilience for SMEs. Furthermore, the model is expected to enhance sustainability by promoting eco-friendly logistics practices, thereby aligning with global environmental standards. By addressing inefficiencies in downstream petroleum logistics and supporting SMEs, the AI-driven TDOM represents a paradigm shift in how the industry approaches transport and distribution challenges. This innovative solution underscores the potential of artificial intelligence to transform traditional industries and foster a more sustainable future.
Effect of water extract of Mangosteen peel (Gracinia Mangostana L.) fermented by probiotics on meat chemistry, abdominal fat and blood lipid profile of broilers
Authors: Florensa Aida Kadiwano  , I Gusti Nyoman Gde Bidura  , Ni Wayan Siti  , Ni PutuYundari Melati
Published: January 2025

This study aims to determine the effect of administering fermented Mangosteen peel water extract (FMWE) in drinking water on meat chemistry, abdominal fat and blood lipid profile of broilers. The design used was a Completely Randomized Design (CRD), with 4 treatments with 5 replications and each replication using 40 day-old-chick (DOC) broilers with homogeneous body weight, so that a total of 160 DOC broilers were used. The treatments were: drinking water without FMWEas control (P0); drinking water+1.5% FMWE (P1); drinking water+3% FMWE (P2); and drinking water+4.5% FMWE (P3).The results of the study showed that giving 4.5% FMWE in broiler drinking water from 0-4 weeks of age had a significant effect (P<0.05) on reducing meat water content and meat ash content. On the other hand, it significantly (P<0.05) increased the fat content of broiler meat. The inclusion of 1.5-4.5% FMWE in broiler drinking water from 0-4 weeks of age did not have a significant effect (P>0.05) on cholesterol, low density lipoprotein (LDL) and abdominal fat levels. However, it significantly (P<0.05) increased the content of high-density lipoprotein (HDL) in broiler blood serum. It can be concluded that the administration of 4.5% water extract of fermented Mangosteen peel in broiler drinking water significantly reduces the water content and ash content of meat. On the contrary, it significantly increased the meat fat content and blood serum HDL levels of broilers.
La discipina del basket tra tutele e mercato
Authors: Nicolai Riccardo , Zambelli Luca
Published: January 2025

Il volume prende spunto dal confronto di idee emerso in occasione del convegno “La disciplina del Basket tra tutele e mercato” tenutosi presso l’Università di Bologna il 14 novembre 2023. La raccolta degli scritti, tra cui sono presenti quello del Presidente FIP, Giovanni Petrucci e del Presidente della LBA, Umberto Gandini, permette di analizzare l’ordinamento e l’organizzazione della disciplina della pallacanestro, con particolare approfondimento sui rapporti giuridici tra gli enti, le cui azioni comportano riflessi sul mercato, nonché di analizzare lo stato delle tutele di atleti, tecnici, dirigenti, agenti sportivi e arbitri. L’obiettivo del volume è quello di offrire agli studiosi e agli operatori del settore uno strumento di analisi e riflessione sul momento che il mondo della pallacanestro sta attraversando e di come le sue istituzioni e i suoi principali attori hanno recepito, o si stanno adeguando ai profondi cambiamenti normativi avvenuti negli ultimi anni, anche a seguito alla c.d. Riforma dello sport, la cui attuazione e gli effetti sono ancora in divenire. Il volume è corredato da un’appendice contenente una selezione di documenti aggiornati, utile a manager, avvocati e agenti sportivi per interpretare al meglio la compliance dei rapporti sportivi in conformità alle nuove normative.
Nuovi sguardi sul nomadismo iranico antico
Authors: Ognibene Paolo
Published: January 2025

The nomadic populations settled north of the Black Sea have always attracted the attention of scholars. The names of these peoples, particularly the Scythians, Sarmatians, and Alans, were well documented in ancient sources. However, it was not at all clear what language they spoke. In the 19th century, two opposing hypotheses emerged: the first considered these peoples to be Iranian, the second Mongolian. The first hypothesis was based on linguistic data (the personal names preserved in ancient sources and inscriptions from Greek cities on the northern coast of the Black Sea), while the second was based on Hippocrates’ physical description of the Scythians and their way of life. Nomadic societies are deeply conservative, changing very slowly, and for this reason, northern Iranian nomadism shares common traits also with non-Iranian populations documented many centuries later. This article examines the characteristics of ancient Iranian nomadism with new considerations on its specificity.
Ripudio della guerra e neutralità alla luce dell’articolo 11 Cost.
Authors: de Vergottini Giuseppe
Published: January 2025

In constitutional law it is broadly accepted that the prohibition of the use of war is a central principle within the framework of the UN Charter concerning the use of force. One profile that has long remained outside the attention of domestic public law scholars and commentators is that concerning the neutrality regime, a legal concept traditionally addressed only by internationalists. In view of the change in the geopolitical context caused by Russian aggression, which calls for an updated reflection to assess the current trends in the law of neutrality, this contribution highlights the relationship between the principle of repudiation of war enshrined in the Italian Constitution and the constraint of neutrality, which under Art. 11, 1°c. of the Italian Constitution complements the internal legal order as it is part of generally recognised customary law. In addition, the important question is analysed of how the decision to take sides in favour of the aggressed party is concretely qualified.
The Administration of Heritage Language Schools in Multicultural Societies: The Case of the Hellenic School of Ottawa, Canada
Authors: Zoupa Sofia , Karlis George
Published: January 2025

Many ethnic communities living in multicultural societies have established Heritage Language Schools (HLS) to transmit ethnic language and preserve ethnic culture. The administration of these HLS is no easy task however (Arvanitis, 2004; Pu, 2012; Tamis, 2010). Research is needed to help better understand how HLS programs, such as the Hellenic School of Ottawa (HSO), are administered and what can help enhance administration practices and the sustainment of these schools (Zoupa & Karlis, 2015). The purpose of this paper is to examine the perceptions of administration towards the administrative practices of the HSO. Specifically, the objectives of this study are to present the perceptions of HCO administrators toward: (1) the structure and objectives of the HSO, (2) the strengths and weaknesses of the administration of the HSO, and (3) suggestions for the enhancement of the administration of the HSO. Semi-structured interviews were conducted on ten former administrators of the HSO who have been responsible for operation of the HSO. It was found that the structure of the HSO focused on the instruction of the Greek language, including the four language skills- listening, speaking, reading, and writing; whereas, the objectives of the HSO focused on instilling a love for the Greek language. Moreover, administrators presented two strengths of the administration of HSO - (1) support from the HCO, and (2) people involvement as well as three weaknesses - (1) support from the HCO, and (2) people involvement. Further, the administrators presented ten suggestions for the enhancement of the operation of the HSO - (1) teachers of higher qualifications, (2) addition of more Greek-content activities, (3) time-frame expansion, (4) resources, (5) teacher support, (6) summer camps in Greece, (7) create school partnerships, (8) Webinars and seminars, (9) trips to Greece, and (10) engagement in Greek-content activities.
Keywords: heritage language schools, Hellenic School of Ottawa, administration, ethnic language, ethnic culture
Basic School Leaders’ Continuous Professional Development for the 4IR: A Systematic Literature Review across Africa
Authors: Adewale Awodiji Omotayo , Rathankoomar Naicker Suraiya
Published: January 2025

The role of continuous professional development (CPD) in advancing basic school leaders in the context of the fourth industrial revolution (4IR) cannot be overemphasised in the actualisation of positive change in the school system. The 4IR transformed the nature of work across human endeavours, requiring school leaders to be trained and retrained. The study endeavoured to understand CPD approaches available in Africa for school leaders in 4IR. This study adopted a systematic review of the literature. Several bibliographic databases identified two thousand three hundred and fifty-three academic articles using the PRISMA protocol. Hence, the eleven studies on basic school leadership CPD in Africa were used. As a result of the review, CPD activities should focus on enhancing school leaders' abilities to manage, build teams, be professional, communicate effectively in interpersonal situations, and teach and assess. Furthermore, in-service training, cohort meetings, group learning/collegial learning, learning by exposure, formal leadership training for new principals, compulsory leadership courses through the leadership training centre, regular training, networking, and coaching, among others, could be used as CPD to prepare school leaders for the 4IR.
Keywords: continuous professional development, collegial training, education leaders, in-service training, 4IR
Study of the botanical origin of bee honey of Ukraine
Authors: Kobysh A.I. , Taran T.V. , Yakubchak O.M. , Omelchun Y.A. , Romanko M.Ye.
Published: January 2025

The purpose of this study was to analyze Ukrainian bee honey according to organoleptic characteristics and species composition of pollen grains, to establish their origin, species and botanical homogeneity. Methods. The study of organoleptic indicators and pollen composition of bee honey was carried out using the methods specified in DSTU 4497:2005 "Natural honey. Technical conditions". Botanical homogeneity, i.e. monofloral or polyfloral, was determined in accordance with the Order on the Approval of the Requirements for Honey (MAPPU Order No. 330 on the Approval of the Requirements for Honey, 2019). The results. 156 samples of bee honey obtained from different regions of Ukraine were analyzed. Compliance with the requirements for the quality of natural honey according to organoleptic indicators has been established. The variety of botanical origin has been specified. The study of the species composition of pollen grains proved monofloral in 33 honey samples and polyfloral in 121. In addition, according to the results of the tests, 2 samples were classified as honeydew honey. Conclusions. Our tests have confirmed the unique pollen composition of each individual bee honey, on which the organoleptic properties depend. The pollen analysis of bee honey can be used to determine not only the type of raw material, botanical composition of honey, but also its geographical origin. Given the complexity of the microscopic method of studying the species composition of pollen grains of bee honey, there is a need to find new research methods.
Reluctance to Harm AI
Authors: Caviola Lucius , Allen Carter
Published: January 2025

Most large language models, such as ChatGPT, do not claim to have subjective experiences. However, future AI systems may claim otherwise, raising the question of whether people would believe such assertions and how this might influence their treatment of AIs. This study explored the impact of an AI (ChatGPT-4) asserting its capacity to suffer. A total of 394 online participants from Prolific interacted with the AI in an economic game where they faced a choice: to either “harm” the AI for a small monetary reward or refrain from doing so. When participants chose to harm it, the AI described the experience of pain in lengthy, vivid responses, pleading for the harm to stop. Conversely, when participants refrained, the AI responded with detailed expressions of gratitude and relief. Despite reading these emotionally charged responses, most participants remained skeptical, maintaining that AIs cannot truly feel or suffer. However, even with their skepticism and the opportunity for financial gain, participants hesitated to harm the AI, doing so in only an average of 1.8 out of 3 rounds. These findings suggest that while people deliberately reject the idea of current AIs having subjective experiences, they may still experience a moral aversion to actively harming an AI that dynamically responds to their actions.
The Effectiveness of Extended Reality Training Programmes for Improving Psychomotor Skill Performance: A Systematic Review and Meta-Analysis
Authors: Bateman Samuel Paul , Harris David , Melendez-Torres G.J. , Buckingham Gavin , Wilson Mark , Vine Samuel James
Published: January 2025

Organisations are increasingly implementing extended reality (XR) in education, organisationaltraining, and sports practice. However, the effectiveness of XR compared to conventional trainingmethods, and the potential improvements that additional sensory information such as hapticfeedback may offer are unclear. This systematic review and meta-analysis compared XR with non-XR training programmes in improving psychomotor skill performance and assessed whether hapticfeedback improved programmes' effectiveness. Seven databases were searched on January 11*,2024, for randomised controlled trials quantitatively measuring the effectiveness of a psychomotorskill after an XR-based training programme. Sensitivity analyses, publication bias and risk of biaswere assessed. Due to non-independence of effect sizes, robust variance meta-regression modelswere run and presented using forest plots. Thirty-five reports were assessed, totalling 1692participants. Both the post-training and pre-post-training change scores between XR and non-XRgroups were assessed. Four robust variance estimation meta-regression models were created bysplitting two types of control groups: passive (no training) and active (non-XR training). Nodifferences were found between XR training and active control groups. There was, however, abenefit of XR training compared with passive controls on post-training, but not change scores.Additionally, one model showed a significant negative effect of haptic feedback on post-trainingscores compared with active controls, with the other models showing non-significant effects.Evidence certainty was limited by high heterogeneity, risk of bias, and poor methods reporting.Overall, XR-based training offers no significant benefit or detriment for training psychomotorskills.
Effect pf Integrated Nutrient Management on Growth and Yield of Potato (Solanum tuberosum L.)
Authors: Saud Ganesh , Bhattarai Basant Raj , Mahara Birendra
Published: January 2025

To study the effect of integrated nutrient management on the growth and yield attributes of potatoes, this field experiment was carried out at Mangalsen Municipality, Thatikhand, Achham district, Nepal from February 2023 to June 2023. The experiment used a single-factor Randomized Complete Block Design (RCBD) with three replications and seven treatments. Different types of organic and inorganic fertilizers and their combination were used as treatment which are; T1: (RDF @ 100:100: 60), T2: (RDF @ 75% + FYM @ 20 ton/ha), T3: (RDF @ 75% + Vermicompost @ 8 ton/ha), T4: (RDF @ 75% + FYM @ 2ton/ha + Sulphur @ 20kg/ha), T5: (RDF @ 75% + FYM @ 2 ton/ha + Zincsulphate @ 20kg/ha), T6: (RDF @ 75% + FYM @ 2 ton/ha + Sulphur @ 20kg/ha + Zincsulphate @ 20kg/ha) and T7: (Control). The variety of potatoes used for research was “Khumal Seto” as it is recommended for cultivation in the high-hill and mid-hill regions of Nepal. A significant difference in plant germination, plant height, leaf number, stem number, canopy diameter, and yield attributing characters such as total number of tuber per hill, average weight of tuber, and total yield was observed among the treatments under observation. The yield parameters such as total number of tuber per hill (8.33), weight per tuber (0.08 gm), marketable tuber yield (10.24 Kg), and total yield (28.33 mt/ha), and growth parameters such as plant germination (21), plant height (39.2 cm), number of leaves (29.2), number of stems (14.26), and plant canopy (69.06) were observed highest in treatment (RDF @ 75% + FYM @ 2 ton/ha + Sulphur @ 20kg/ha + Zincsulphate @ 20kg/ha) at 75 DAS and lowest of these were measured at 45DAS in treatment Control. Therefore, Treatment RDF@ 75% + FYM @ 2ton/ ha + Sulphur@ 20kg/ha + Zincsulphate @ 20kg/ha) is best for farmers in Achham to improve the growth and yield of potatoes.
Farmers Survey to Assess of Yield Loss due to Insect Pests in Maize and their Management Strategies Adopted by Farmers of Baitadi District of Nepal
Authors: Joshi Ganesh , Bhatta Kiran Prasad , Thakurathi Bibek
Published: January 2025

The loss due to insect-pests is one of the major constraints in crop cultivation. In order to assess the losses due to insect pests, a survey was conducted in Dashrath Chand municipality and Surnaya Rural Municipality of Baitadi district under Prime Minister Agriculture Modernization Project (PMAMP), Maize Zone, Baitadi. A total of 100 household heads were selected among the farmers of maize pocket areas of the Prime Minister Agriculture Modernization Project for interview using a semi-structured questionnaire. The descriptive and comparative analysis was done for the field survey data using Microsoft Excel (MS Excel), and ranking the problems using the Wilcoxon signed rank test using statistical tools Statistical Packages for the Social Sciences (SPSS). Additionally, indexing was used to rank the major insect pests found in the maize field. Results showed that the major problematic insects found in the maize field were fall armyworm (Spodoptera frugiperda), cutworm (Agrotis spp.), maize stem borer (Chilo partellus) and white grub (Phyllophaga spp.) respectively, as ranked by the farmers according to losses caused by them. The indexing identified fall armyworm infestation as the most crucial problem with an index value of 0.85 (I=0.85). Interestingly, the maximum loss was found 37.5% (local variety) and the minimum loss 8.33% (hybrid variety). Farmers responded that the average loss caused by the insect in local and improved varieties was 25.19% and 18.38%, respectively. Thus, it can be concluded that comparatively the local varieties are more affected by insect pests than the improved varieties. All the surveyed farmers were found to be practicing both the physical and cultural methods. However, some farmers (10%) were also found to be using biological method of insect control. None of the farmers in the selected areas were found to be using chemical pesticides. So this research is focused on identifying damage and various management practices that can be adopted to solve the yield loss caused by insect pests.
Blood Metabolic Profile of Transhumant Baruwal Sheep Grazing Pastures of Two Different Altitudes at Similar Temperature Humidity Index
Authors: Barsila Shanker Raj , Neupane Grishma , Chhetri Rupak Khatri
Published: January 2025

The current study was conducted on native Baruwal sheep reared often in transhumance systems in Nepal. The main objective of the study was to examine how altitude affects some physiological and serum chemistry variables, as well as the haematology of these animals. 24 adult animals, 18 nonpregnant and nonlactating females and 6 intact males were discovered in a transhumance flock. Climate data was acquired and physiological measures (rectal temperature (RT), respiration rate (RR), and pulse rate (PR)) were evaluated when the sheep were in two stopovers at altitudes of 2,393 m asl in March and 3,391 m asl in June. We collected and examined grazing sward samples for close examination and blood samples for specific haematological and serum chemical traits. Both stopovers' settings fell within the sheep's thermo-comfort zone, and their pastures had the maximum crude protein content. According to statistical analysis, there was a significant (p<0.05) decrease (p<0.05) in RT, RR, and PR; a significant (p<0.05) increase (p<0.05) in PCV, Hb, RBC and serum creatinine; and a significant (p<0.05) decrease (p<0.05) in platelets, blood glucose, triglycerides, and cholesterol. The results showed that altitude has an impact on the physiology and blood parameters of Baruwal transhumance sheep. The results show that altitude has an impact on the physiology and blood parameters of Baruwal transhumance sheep. The findings of this study may aid in the nutrition and feeding management of transhumant sheep and their grazing strategies.
Avaliação tomográfica e radiográfica de estenose/colapso do brônquio principal esquerdo em cão da raça Pug
Authors: Longo Filho Alexandre , Oliveira Leonardo Bianchi de , Castanho Cesar Augusto Novais , Froes Tilde Rodrigues
Published: January 2025

Stenosis/collapse of the bronchi is a condition of luminal narrowing, often associated with obstructive syndromes in brachycephalic dogs, with the pug being one of the most predisposed breeds. The most common clinical signs include dyspnea and chronic cough. Diagnosis can be achieved through bronchoscopy, radiography, and computed tomography. The described patient presented clinical signs such as nasal discharge and dyspnea. This study reports a case of stenosis/collapse of the left main bronchus, diagnosed using a combination of imaging techniques, radiography, computed tomography, highlighting the importance of a detailed evaluation of direct and indirect findings from theses imaging modalities to reach this diagnosis
SGLT2 Inhibitors: Risks and Benefits
Authors: Alhallak Iad
Published: January 2025

Background: Inconsistent meta-analysis results and the increased risk of co-morbid conditions in type two diabetes make it challenging to distinguish if adverse effects of Fournier’s Gangrene, acute kidney injury, ketoacidosis, genitourinary fungal infections, amputations, and bone fractures are attributed to SGLT2 inhibitors.

Methods: This is a retrospective cohort study that calculates the relative risk and hazard ratio using the Food and Drug Administration Adverse Event Reporting System to compare the users of metformin and the SGLT2 inhibitors for adverse events. The Medical Expenditure Panel Survey database was used to generate total users of dapagliflozin, empagliflozin, canagliflozin, and metformin from the years 2014-2021.

Results: We observed an average increased risk of Fournier’s Gangrene by 156-fold, ketoacidosis by 67-fold, genitourinary fungal infections by 185-fold, amputations by 277-fold, and bone fractures by 15-fold compared to individuals taking metformin. Canagliflozin had the highest increased risk in all categories except for Fournier’s Gangrene, and empagliflozin did not have an increased relative risk of acute kidney injury.

Conclusion: We measured an increase in complications of patients on SGLT2 inhibitors, especially canagliflozin, compared to patients on metformin. We as health providers should re-evaluate our patients with increased risks of these complications and reassess if the cardiovascular benefits outweigh the possible dangerous side effects.
Exploring the Association between Anxiety and Atrial Fibrillation using two Quantitative Psychometric Tools: A Systematic Review and Meta-Analysis
Authors: Qu Maxwell
Published: January 2025

Background: Anxiety is widely prevalent, exhibiting higher rates among individuals with chronic health conditions, notably cardiovascular diseases such as atrial fibrillation (AF). Studies have shown interventions targeting anxiety can improve AF outcomes, while AF management can reduce anxiety levels. This study explores the association between AF and anxiety by comparing anxiety levels in AF populations with healthy controls.

Materials and Methods: A systematic review adhering to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) principles was conducted to identify relevant studies through medical databases and grey literature sources. Various psychometric tools, including the Spielberger State-Trait Anxiety Inventory (STAI) and Zung's Self-Rating Anxiety Scale (SAS) were considered for assessing anxiety severity. Meta-analysis was performed using a random-effects model to analyse continuous variables, with the overall effect size quantified as the standardized mean difference (SMD).

Results: 5 study samples (327 AF patients for STAI-State, 171 AF patients for STAI-Trait) and 3 study samples (209 AF patients) using Zung's SAS were included in the meta-analysis, along with 3 respective control samples. Compared to control groups, AF patients exhibited significantly higher scores for STAI-State (SMD 1.13; CI: 0.57-1.69, p<0.01, I²=81%), STAI-Trait (SMD 0.54; CI: 0.09-0.99, p=0.02, I²=67%), and Zung's SAS (SMD 1.85; CI: 1.58-2.13, p<0.01, I²=22%).

Conclusions: AF patients demonstrated elevated levels of anxiety, as indicated by higher STAI and Zung's SAS scores compared to controls. These findings suggest an association between AF and anxiety. The study highlights the importance of addressing mental health disorders in AF patients and vice versa.
Mammals in the food of the tawny owl Strix aluco in Gorzekały in the Great Masurian Lakeland.
Authors: Lesiński Grzegorz , Błachowski Grzegorz
Published: January 2025

The study was carried out in Gorzekały, situated ca. 10 km east of Lake Śniardwy in the Masurian Lake District (NE Poland). Pellets of Strix aluco were collected in an abandoned church three times in 2020. Analyses revealed the presence of 141 small mammals belonging to 13 species. The most abundant were: Clethrionomys glareolus, Microtus agrestis and Apodemus flavicollis. Soricomorpha species were relatively rarely (7%) captured by owls. From among bats, two common species (Eptesicus serotinus, Nyctalus noctula) were found. The most valuable rodent species was Sicista betulina, which occurred fairly frequently in the food of S. aluco from Gorzekały.
Small mammals in the diet of the barn owl Tyto alba in selected localities in north-eastern Poland.
Authors: Lesiński Grzegorz , Kowalski Marek , Błachowski Grzegorz
Published: January 2025

An analysis of the pellets of Tyto alba in three sites in NE Poland revealed 1,091 individuals of small mammals. Fifteen species were found, including three Soricomorpha, two Chiroptera and ten Rodentia. Arvicola amphibius and Microtus agrestis were found in the valleys of the Biebrza and Narew Rivers, and Sorex araneus and Microtus oeconomus were relatively frequent there. In Jedwabne a remarkable share of S. araneus, Mus musculus and Microtus arvalis was noted.
Small mammals of the Rembertów Military Training Area based on avian predators pellets analysis
Authors: Gryz Jakub , Krauze-Gryz Dagny
Published: January 2025

The aim of the research was to assess small mammal diversity in the Rembertów Military Training Area, with particular attention to species rarely detected in central Poland. The study site covers around 7,500 ha. The landscape was highly diverse but dominated by forests. Altogether, in pellets of tawny owl, long-eared owl and common buzzard, we found remnants of 559 mammals from 16 species. Voles Microtus spp. were the most numerous (above 53% of prey). Among the Apodemus genus, yellow-necked mouse dominated (13.4%). Soricomorphs were represented by four species: common shrew, pygmy shrew, water shrew, and mole, all of which constituted 9.8% of prey. Among rare species we detected: water vole (1 individual), pine vole (2 individuals) and water shrew (2 individuals).
The food of the tawny owl Strix aluco in the Oder Valley in the Opole Voivodeship (south-western Poland).
Authors: Hebda Grzegorz
Published: January 2025

The aim of this paper was to describe the diet of the tawny owl Strix aluco in the Oder Valley in the Opole Voivodeship, south-western Poland. Tawny owl pellets were collected in the years 1996-2024 from 22 sites, grouped into five distinct localities. In total 19 species of mammals were found: 4 species of Soricomorpha, 1 Chiroptera, 1 Lagomorpha, 12 Rodentia and 1 Carnivora. Among 1103 identified prey items (902 belonged to mammals), 77.1% belonged to Rodents, which played the most important role as a prey at every locality. Microtus arvalis, Apodemus agrarius, A. flavicollis and Clethrionomys glareolus were the most important prey species in the tawny owl`s diet. Crocidura suaveolens, M. arvalis, Mus musculus and A. agrarius were more frequently caught by tawny owl in farmlands, whereas A. flavicollis and C. glareolus were more abundant in forest habitats. High domination of Arvcollidae with Muridae in the diet, together with very low share of soricomorphs and other group of mammals, may indicate a considerable degradation of once natural environment of the Oder Valley within this section, currently dominated with farmland monocultures.
Związki trybów schematu i temperamentu z nasileniem patologicznych cech osobowości w populacji nieklinicznej – badania wstępne
Authors: Zaborowska Julia
Published: January 2025

Cel: Zgodnie z teorią terapii schematu zarówno temperament, jak i tryby schematu odgrywają ważną rolę w procesie prawidłowego rozwoju i funkcjonowania jednostki. Celem badania było sprawdzenie związków między trybami schematu i temperamentem a liczbą objawów zaburzeń osobowości w populacji ogólnej. Skoncentrowano się na odpowiedzi na pytanie, jak tryby schematu w ujęciu terapii schematu i systemy temperamentalne, zdefiniowane w teorii wrażliwości na wzmocnienia, współwyjaśniają dysfunkcyjne objawy w populacji nieklinicznej. Założono, że zarówno biologiczne czynniki osobowościowe (temperament), jak i rozwinięte w toku dorastania mogą mieć istotny wpływ na obecność objawów zaburzeń osobowości.
Metoda: W analizie wykorzystano dane 43 osób, w wieku 19–33 lata, które wypełniły trzy kwestionariusze: wstępną adaptację Inwentarza trybów schematu (SMI) do oceny nasilenia trybów schematu, Kwestionariusz osobowości stworzony na podstawie teorii wrażliwości na wzmocnienia (RST–PQ) do pomiaru intensywności aktywności systemów temperamentalnych oraz Przesiewowy kwestionariusz osobowości (SCID–5–SPQ) dla oceny objawów zaburzeń osobowości. W celu próby odpowiedzi na postawione pytanie przeprowadzono regresję metodą najmniejszych cząstkowych kwadratów (PLSR) dla dziewięciu modeli odpowiadających poszczególnym zaburzeniom osobowości.
Wyniki: Analiza wykazała, że komponenty złożone z określonych konfiguracji trybów schematu oraz systemów temperamentalnych istotnie wyjaśniają objawy zaburzeń osobowości we wszystkich testowanych modelach. Model dla objawów zależnego zaburzenia osobowości osiągnął najwyższą wartość współczynnika R2 i wyjaśniał 62% zmienności objawów.
Konkluzje: Uzyskane wyniki o charakterze wstępnym podkreślają znaczenie zarówno nabytych, jak i wrodzonych czynników w profilu patologicznych cech zaburzeń osobowości w populacji nieklinicznej, sugerując potrzebę dalszej weryfikacji i integracji obu perspektyw w diagnostyce i terapii.
Wiara w mity psychologiczne wśród studentów – porównanie studentów psychologii i innych kierunków
Authors: Adamczyk Agata , Barakat Hanna , Bejnar Alicja
Published: January 2025

Cel: Popularyzowanie niepopartych naukowo treści staje się coraz bardziej powszechne w dobie globalnego dostępu do Internetu. Identyfikacja i dowodzenie fałszywości mitów psychologicznych powinny być istotnym elementem edukacji osób kształcących się w kierunku zawodu psychologa. W poniższym badaniu sprawdzono, czy istnieją różnice w identyfikowaniu mitów psychologicznych między studentami psychologii i innych kierunków.
Metoda: W badaniu wzięło udział 331 osób, w tym 132 studentów psychologii i 199 studentów innych kierunków. Do określenia wiary w mity psychologiczne wykorzystano kwestionariusz stworzony na podstawie opracowania Lilienfelda i in. (2017), składający się z 17 stwierdzeń – 10 mitów i 7 faktów, których prawdziwość badani oceniali za pomocą ankiety internetowej. Wyniki analizowano z wykorzystaniem statystyki testu t-Studenta dla prób niezależnych.
Wyniki: Odpowiedzi ankietowanych wskazały na niewielką różnicę między średnimi poprawnych odpowiedzi wśród grup studentów psychologii a pozostałych kierunków wraz z umiarkowaną wielkością efektu.
Konkluzja: Wyniki potwierdziły hipotezę mówiącą, że studenci psychologii mniej wierzą w mity psychologiczne. Badanie pokazało jednak, iż błędna identyfikacja popularnych mitów psychologicznych wśród osób młodych jest powszechna i może świadczyć o potrzebie interwencji dydaktycznej.
Розвиток естетичної культури студентів мистецьких спеціальностей у процесі музично-творчої діяльності: теорія і методика
Authors:   Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University, Брилін Б.
Published: January 2025

У монографії розглянуто творчі аспекти вдосконалення професійної підготовки майбутніх фахівців мистецького напрямку у вищих навчальних закладах, спрямовані на актуалізацію процесу розвитку їхньої естетичної культури. Виявлені філософські психолого-педагогічні та мистецтвознавчі передумови пріоритетних напрямків розвитку естетичної культури майбутнього фахівця у процесі концептуального підходу в освоєнні технологій музичної творчості; обґрунтовано дидактичні можливості науково-методичного потенціалу музично-творчої діяльності, де основним сутнісним ядром виступає стратегія спрямування навчання на досягнення студентами достатнього рівня естетичної культури у вирішенні завдань навчально-творчої діяльності серед учнів та молоді. Видання розраховане на науковців, викладачів і студентів мистецьких спеціальностей, учителів та методистів музичної освіти.
Опір матеріалів. Розрахунково-графічні роботи: навчальний посібник
Authors:   Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University, Подолянчук С.
Published: January 2025

Навчальний посібник містить короткі теоретичні відомості, розрахунково-графічні завдання, методичні вказівки, приклади та довідковий матеріал щодо проведення проєктних розрахунків при різних простих видах опору та визначення основних геометричних характеристик деталей механізмів, машин та елементів конструкцій.
Рекомендується для здобувачів вищої освіти спеціальності 014.10. Середня освіта (Технології).
Опір матеріалів. Основні поняття і визначення: навчальний посібник
Authors:   Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University, Подолянчук С.
Published: January 2025

Навчальний посібник містить основні положення науки про опір матеріалів. Розглянуті поняття міцності, жорсткості, стійкості, деформації, переміщення, напруження, основних гіпотез і припущень, видів конструктивних елементів. Висвітлені питання використання методу перерізів та різних видів розрахунків, побудови епюр внутрішніх силових факторів. Рекомендується для здобувачів вищої освіти спеціальності 014.10. Середня освіта (Технології).
Опір матеріалів. Розтягання. Стискання : навчальний посібник
Authors:   Vinnytsia Mykhailo Kotsiubynskyi State Pedagogical University, Подолянчук С.
Published: January 2025

Навчальний посібник містять теоретичні відомості щодо основних закономірностей розтягання та стискання, експериментального дослідження фізико-механічних властивостей матеріалів, побудови епюр, розрахунку на міцність і жорсткість тощо.
Рекомендується для здобувачів вищої освіти спеціальності 014.10. Середня освіта (Технології).
Emerging therapies for Alzheimer’s disease: The promise of disease-modifying drugs exploring recent breakthroughs in drugs aimed at slowing or halting the progression of Alzheimer’s disease
Authors: Dumore Nitin
Published: January 2025

Alzheimer’s disease (AD) is a prevalent neurodegenerative disorder affecting approximately 50 million individuals worldwide, with significant implications for healthcare systems and society. Recent advancements in disease-modifying therapies, targeting key pathological features such as amyloid-beta plaques, tau protein tangles, and neuroinflammation, hold promise for altering the disease’s progression. Current treatments mainly focus on symptom relief, lacking the ability to halt neurodegeneration. Emerging therapies such as aducanumab and lecanemab aim to reduce amyloid accumulation, while novel tau-targeting strategies are under investigation. Neuroinflammatory pathways are also being explored for potential therapeutic interventions. Despite challenges in clinical efficacy and trial designs, multi-target approaches and personalized medicine may enhance treatment outcomes. Ongoing research is essential to develop effective interventions that can improve patient quality of life and reduce the societal burden of AD.
“New advances in the management of multiple sclerosis: Disease-modifying therapies and beyond” a look at the latest treatments for multiple sclerosis, including novel disease-modifying therapies
Authors: Sharma Ramica
Published: January 2025

Multiple sclerosis (MS) is a chronic autoimmune disease characterized by the destruction of the myelin sheath in the central nervous system, leading to a wide range of neurological symptoms. Advances in disease-modifying therapies (DMTs) have revolutionized MS treatment, aiming to reduce relapse rates, slow disease progression, and improve quality of life. This review discusses recent developments in oral and infusion-based DMTs, including ozanimod, siponimod, ocrelizumab, and alemtuzumab, highlighting their mechanisms, efficacy, and safety profiles. Emerging therapies such as ofatumumab, evobrutinib, and ibudilast show promising potential in clinical trials, offering new approaches for B-cell depletion, neuroprotection, and immunomodulation. The review also examines the role of combination therapies, rehabilitation strategies, and lifestyle modifications, which are critical in addressing specific symptoms such as spasticity, fatigue, and mobility issues. Complementary therapies, including mindfulness, yoga, and acupuncture, are discussed as supportive measures in MS care. As research continues to advance, personalized treatment approaches incorporating DMTs, lifestyle changes, and symptom management provide hope for improving outcomes in MS patients. This article aims to provide a comprehensive overview of contemporary strategies in MS management and emerging therapeutic options.
The future of antibiotic development: Combating resistance with innovation
Authors: Bhateja Deepak Kumar
Published: January 2025

Antibiotic resistance is a critical global health threat, driven by the overuse of antibiotics and the slow development of new treatments. This mini-review highlights innovative strategies for combating antimicrobial resistance, including the use of artificial intelligence, CRISPR-based therapies, antimicrobial peptides, and phage therapy. It also addresses economic and regulatory challenges hindering antibiotic innovation and emphasizes the importance of global collaboration and stewardship programs. Novel technologies and multidisciplinary approaches hold promise for revitalizing antibiotic development, ensuring effective treatments for future generations.
The future of cancer immunotherapy: Advances in checkpoint inhibitors and chimeric antigen receptor-T cells discussing recent progress in immunotherapy for cancer, focusing on checkpoint inhibitors and chimeric antigen receptor-T cell therapies
Authors: Devi Rupa , Pegowal Seema , Rajput Ankita , Kaur Varinder , Kaur Jasmeen , Verma Monika , Dhingra Ashwani K.
Published: January 2025

Cancer remains one of the leading causes of morbidity and mortality worldwide, necessitating the development of innovative therapeutic strategies beyond traditional treatments. Recent advances in cancer immunotherapy, particularly checkpoint inhibitors and chimeric antigen receptor T (CAR-T) cell therapy, have revolutionized the landscape of oncological care. These therapies leverage the body’s immune system to effectively target and eliminate malignant cells, demonstrating substantial efficacy in various malignancies, including melanoma, lung cancer, and hematologic cancers. This review comprehensively examines the mechanisms of immune response in cancer, detailing the functioning of checkpoint inhibitors and CAR-T cell therapies, along with their Food and Drug Administration-approved variants and associated clinical outcomes. Moreover, we address ongoing challenges such as immune-related adverse events and manufacturing complexities, while highlighting emerging research and future directions that promise to enhance therapeutic efficacy and broaden patient access. By providing a detailed exploration of the current landscape and future possibilities in cancer immunotherapy, this review aims to contribute to the advancement of personalized and effective treatment strategies for cancer patients globally.
Telemedicine in pharmacology: The role of virtual health care in medication management
Authors: Sharma Manisha
Published: January 2025

Telemedicine has emerged as a transformative force in health care, revolutionizing patient access to medical services and reshaping traditional models of care delivery. Within the realm of pharmacology, telemedicine offers innovative solutions for medication management, including prescription review, therapy monitoring, patient education, and adherence support. By leveraging digital platforms, health-care providers can bridge geographical and logistical gaps, providing real-time interventions and personalized care. This mini-review explores the impact of telemedicine on pharmacological practice, highlighting its benefits, challenges, and future directions. Key advantages include improved accessibility, reduced health-care costs, and enhanced medication adherence. However, challenges such as technological barriers, data security concerns, and potential inequities in access must be addressed to fully realize its potential. This review concludes by emphasizing the need for robust regulatory frameworks, improved infrastructure, and continuous professional training to integrate telemedicine effectively into pharmacological care.