bluuebunny/crossref_metadata_2025 huggingface dataset:
HIV-1 subtype B spread through cross-border clusters in the Balkans: a molecular analysis in view of incidence trends
Authors: Jovanovic Luka , Siljic Marina , Cirkovic Valentina , Salemovic Dubravka , Jevtovic Djordje , Alexiev Ivailo , Zidovec-Lepej Snjezana , Oroz Maja , Begovac Josip , Paraskevis Dimitrios , Skoura Lemonia , Chaztidimitriou Dimitrios , Kostaki Evangelia G. , Dragas Snezana , Dupanovic Brankica , Otelea Dan , Paraschiv Simona , Poljak Mario , Lunar Maja M. , Stanojevic Maja
Published: September 2022

Objectives:

To analyze phylogenetic relations and assess the role of cross-border clusters in the spread of HIV-1 subtype B across the Balkans, given the general trends of new HIV diagnoses in seven Balkan countries.

Design:

Retrospective phylogenetic and trend analysis.

Methods:

In-depth phylogenetic, phylodynamic and phylogeographic analysis performed on 2415 HIV-1 subtype B sequences from 1999 to 2019 using maximal likelihood and Bayesian methods. The joinpoint regression analysis of new HIV diagnoses by country and modes of transmission using 2004–2019 ECDC data.

Results:

Ninety-three HIV-1 Subtype B transmission clusters (68% of studied sequences) were detected of which four cross-border clusters (11% of studied sequences). Phylodynamic analysis showed activity of cross-border clusters up until the mid-2000s, with a subsequent stationary growth phase. Phylogeography analyses revealed reciprocal spread patterns between Serbia, Slovenia and Montenegro and several introductions to Romania from these countries and Croatia. The joinpoint analysis revealed a reduction in new HIV diagnoses in Romania, Greece and Slovenia, whereas an increase in Serbia, Bulgaria, Croatia and Montenegro, predominantly among MSM.

Conclusion:

Differing trends of new HIV diagnoses in the Balkans mirror differences in preventive policies implemented in participating countries. Regional spread of HIV within the countries of former Yugoslavia has continued to play an important role even after country break-up, whereas the spread of subtype B through multiple introductions to Romania suggested the changing pattern of travel and migration linked to European integration of Balkan countries in the early 2000s.
Bilateral Axillary Nodal Uptake on 99mTc–White Blood Cell Study Secondary to COVID-19 mRNA Vaccination
Authors: Namous Nadia A. , Kushner Daniel , Dadparvar Simin
Published: September 2022

A 77-year-old man with a history of chronic lower back pain, and prior spinal fusion surgery X2 was referred for 99mTc-WBC Study for evaluation of worsening back pain and cervical radiculopathy to rule out any signs of infection. The patients white blood cells were tagged with 99mTc-HMPAO (hexamethylpropylene amine oxime), and planar and SPECT/CT imaging was performed at 4 and 24 hours. 99mTc-WBC Study showed no abnormal isotope localization in the spine; however, there was an incidental finding of bilateral increased soft tissue uptake in axillary lymph nodes. Medical history revealed intramuscular injection of second and third dose of Moderna mRNA COVID-19 vaccine in bilateral deltoids approximately 11 and 5 months before scan.
A minimal model of elastic instabilities in biological filament bundles
Authors: Prior Chris , Panter Jack , Kusumaatmaja Halim
Published: September 2022

We present a model of a system of elastic fibres which exhibits complex, coupled, nonlinear deformations via a connecting elastic spring network. This model can capture physically observed deformations such as global buckling, pinching and internal collapse. We explore the transitions between these deformation modes numerically, using an energy minimization approach, highlighting how supported environments, or stiff outer sheath structures, favour internal structural collapse over global deformation. We then derive a novel analytic buckling criterion for the internal collapse of the system, a mode of structural collapse pertinent in many biological filament bundles such as the optic nerve bundle and microtubule bundles involved in cell abscission.
From evidence-based medicine to digital twin technology for predicting ventricular tachycardia in ischaemic cardiomyopathy
Authors: de Lepper Anouk G. W. , Buck Carlijn M. A. , van ‘t Veer Marcel , Huberts Wouter , van de Vosse Frans N. , Dekker Lukas R. C.
Published: September 2022

Survivors of myocardial infarction are at risk of life-threatening ventricular tachycardias (VTs) later in their lives. Current guidelines for implantable cardioverter defibrillators (ICDs) implantation to prevent VT-related sudden cardiac death is solely based on symptoms and left ventricular ejection fraction. Catheter ablation of scar-related VTs is performed following ICD therapy, reducing VTs, painful shocks, anxiety, depression and worsening heart failure. We postulate that better prediction of the occurrence and circuit of VT, will improve identification of patients at risk for VT and boost preventive ablation, reducing mortality and morbidity. For this purpose, multiple time-evolving aspects of the underlying pathophysiology, including the anatomical substrate, triggers and modulators, should be part of VT prediction models. We envision digital twins as a solution combining clinical expertise with three prediction approaches: evidence-based medicine (clinical practice), data-driven models (data science) and mechanistic models (biomedical engineering). This paper aims to create a mutual understanding between experts in the different fields by providing a comprehensive description of the clinical problem and the three approaches in an understandable manner, leveraging future collaborations and technological innovations for clinical decision support. Moreover, it defines open challenges and gains for digital twin solutions and discusses the potential of hybrid modelling.
Molecular characteristics of the edge cells responsible for expansion of the chick embryo on the vitelline membrane
Authors: Lee Hyung Chul , Fadaili Yara , Stern Claudio D.
Published: September 2022

During early avian development, only a narrow band of cells (the edge cells, also called ‘margin of overgrowth’) at the rim of the embryo is responsible for blastoderm expansion by crawling over the vitelline membrane (VM) to cover the whole egg yolk in just 4 days (a process called epiboly). Surprisingly, this has not yet been studied in detail. Here we explore the edge cells of the chick embryo using
in situ
hybridization, immunohistochemistry and live imaging. Morphological and molecular properties reveal that the edge has a distinctive structure, being subdivided into sub-regions, including at least four distinct zones (which we name as leading, trailing, deep and stalk zones). This allows us to study reorganization of the edge region that accompanies reattachment of an explanted blastoderm to the VM. Immunohistochemistry uncovers distinct polarized cellular features resembling the process of collective cell migration described in other systems. Live imaging reveals dynamic lamellipodial and filopodial activity at the leading edge of the outermost cells. Our data provide evidence that edge cells are a distinct tissue. We propose that edge cells may be a useful model system for the study of wound healing and other closure events in epithelial cell sheets.
Does Internal Preoccupation with Obsessive-Compulsive Themes Affect Externally Oriented Functioning in OCD?: Behavioral Results and Clinical Cases
Authors: Bednarek Lora , Glover Stephanie , Ma Xiao , Pittenger Christopher , Pushkarskaya Helen
Published: September 2022

Individuals with obsessive-compulsive disorder (OCD) exhibit nonspecific deficits in executive function. Internal preoccupations with obsessive-compulsive themes (OCs) may prevent individuals with OCD from fully engaging in externally oriented tasks, explaining these deficits – an ‘executive overload’ model of OCD.

This study reports data from 43 individuals with OCD and 54 healthy individuals collected using the revised Attention Network Test (ANT-R) that is consistent with predictions of the ‘executive overload’ model. During ANT-R, externally orienting cues enhanced individual readiness to respond to external stimuli (alerting benefits), but alerting benefits were negatively associated with severity of internal preoccupations (e.g., neutralizing and obsessing symptoms). Alerting cues improved efficacy of conflict processing (executive benefits), more in individuals with OCD than in healthy controls. These executive benefits correlated positively with the severity of contamination.

Internal preoccupation with OCs could also contribute to poor engagement with exposure and response prevention (ERP) exercises and, consequently, might explain the limited efficacy of ERP-based interventions in some patients. This study describes two clinical cases to illustrate how personalized externally orienting cues may augment ERP exercises to improve patients’ engagement in therapeutic interventions.

The study concludes with discussion of broader implications of the results and with new hypotheses for future investigations.

Highlights

Internal preoccupations negatively impact executive function in OCD.

Externally orienting cues improve readiness to respond to external stimuli in OCD.

Externally orienting cues improve efficacy of conflict processing in OCD.

Effects of externally orienting cues vary across obsessive-compulsive themes.

Efficacy of ERP could be improved by augmenting with externally orienting cues.
Differential elasticity in lineage segregation of embryonic stem cells
Authors: Ritter Christine M. , Leijnse Natascha , Barooji Younes Farhangi , Brickman Joshua M. , Doostmohammadi Amin , Oddershede Lene B.
Published: September 2022

The question of what guides lineage segregation is central to development, where cellular differentiation leads to segregated cell populations destined for specialized functions. Here, using optical tweezers measurements of mouse embryonic stem cells (mESCs), we reveal a mechanical mechanism based on differential elasticity in the second lineage segregation of the embryonic inner cell mass into epiblast (EPI) cells – that will develop into the fetus – and primitive endoderm (PrE) – which will form extraembryonic structures such as the yolk sac. Remarkably, we find that these mechanical differences already occur during priming and not just after a cell has committed to differentiation. Specifically, we show that the mESCs are highly elastic compared to any other reported cell type and that the PrE cells are significantly more elastic than EPI-primed cells. Using a model of two cell types differing only in elasticity we show that differential elasticity alone can lead to segregation between cell types, suggesting that the mechanical attributes of the cells contribute to the segregation process. Our findings present differential elasticity as a previously unknown mechanical contributor to the lineage segregation during the embryo morphogenesis.
A method to predict structural dynamic strain based on acceleration signal
Authors: Zhang Yujie , Niu Wenchao , Li Bin
Published: September 2022

Purpose

Structural stress and strain in the key components of aircraft structure is important for structural health monitoring and strength assessment. However, the measure of dynamic strain is often difficult to implement because of the complex test equipment and inconvenient measure points, especially in flight test. This study aims to propose an algorithm of dynamic strain estimation using the acceleration response in time domain to simplify the measure of dynamic strain.

Design/methodology/approach

The relationship between the strain and acceleration response is established through the sinusoidal response or modal analysis, which is insensitive to the excitation position and form. A band-pass filter is used to obtain the modal acceleration response, and a filter frequency band selection method is proposed. Then, the dynamic strain at the concerned points can be estimated based on the modal superposition principle.

Findings

Simulation and experiment are implemented to validate the applicability and effectiveness of the strain estimation method. The estimated strain results agree well with numerical simulation as well as the experimental results. The simplicity and accuracy of the strain estimation method show practicability for dynamic strength and fatigue analysis in engineering applications.

Originality/value

An algorithm of dynamic strain estimation using the acceleration response in time domain is developed. A band-pass filter is used to obtain the modal acceleration response, and a filter frequency band selection method is proposed. The dynamic strain at the concerned points can be estimated based on the modal superposition principle.
Measuring and assessing international diversification strategies of Indian companies
Authors: Bhatia Aparna , Khurana Meenu
Published: September 2022

Purpose

The paper aims to measure the nature and extent of international diversification followed by Indian companies over the period 2009–10 to 2017–18. The study also aims to assess the pattern of transition of companies to various strategies of international diversification.

Design/methodology/approach

Jacquemin and Berry’s (1979) entropy approach has been applied to measure the extent and assess the nature of international diversification. Further, the study deploys two-dimensional categorical framework advocated by Vachani (1991) and categorizes the firms into four international diversification strategies.

Findings

Larger proportion of companies in internationally low diversification (ILD) strategy reveals low extent of international diversification of Indian companies. The pattern of diversification depicts that the trend of moving forward is speeding up sequentially toward higher strategies of growth. Both the extent and pattern depict that the nature of diversification is shifting from relatedness to un-relatedness with transitions from intra-regions to inter-regions. The study confirms the applicability of eclectic theory and psychic distance Uppsala model in determining the preference of international diversification strategies and process of internationalization respectively in Indian firms.

Originality/value

The paper is first of its kind on account of several reasons. First, such a comprehensive evaluation of preferences for international diversification strategies has never been taken up with reference to emerging economies, especially India. Second, the paper is not static and does not limit itself only to the identification of favored strategies of Indian companies but also gauges the transitional behavior of Indian companies across different strategies at different points of time. In fact it is the first study to statistically research the applicability of psychic distance model in firms in emerging economy. Third, the results not only measure the quantum of international diversification but also assess the extent of relatedness and un-relatedness followed by Indian companies.
Study on TEHL flash temperature of helical gear pair considering profile modification
Authors: Liu Yue , Gong Jiayu
Published: September 2022

Purpose

The purpose of this paper is to investigate the thermal elastohydrodynamic lubrication (TEHL) flash temperature of the helical gear pairs considering profile modification.

Design/methodology/approach

A flash temperature model of the helical gear pair considering the profile modification is proposed based on the TEHL and meshing theories. In doing so, the slicing, fast Fourier transform and chase-after methods are applied to accurately and rapidly obtain the flash temperature of the gear pair. Then, the effects of the modification, input torque and rotation speed on the flash temperature are studied.

Findings

With the increment of the tip relief amount, the flash temperature of the helical gear pair with the axial modification decreases first and then increases, and the meshing position of the maximum flash temperature moves toward the pitch point. Moreover, reducing the input torque or increasing the rotation speed can efficiently reduce the TEHL flash temperature.

Originality/value

This work is a valuable reference for the profile design and optimization of the helical gears to avoid the excessive flash temperature.
Experimental investigation for novel hybrid journal bearing with hydrostatic squeeze film and metal mesh damper in series
Authors: Qin Xin , Wang Xiaojing , Qiu Zhengmao , Hao Yifan , Zhu Yan
Published: September 2022

Purpose

This study aims to present a novel hydrostatic squeeze film-metal mesh journal bearing (HS-MMJB), which uses both hydrostatic squeeze film damper (HSFD) and metal mesh damper (MMD), to suppress the vibration of rotor-bearing systems.

Design/methodology/approach

The lubrication equations were introduced to calculate the dynamic characteristics of HS-MMJB, and the response analyses of rotor systems were carried out. Experiments were conducted to study the vibration reduction of a rotor system with HS-MMJB. In addition, experiments for different oil supply pressures in the HS-MMJB were conducted.

Findings

The theoretical and experimental results show that the HS-MMJB exhibits excellent damping and vibration attenuation characteristics. Moreover, the stability of the rotor system can be improved by controlling the oil supply pressure.

Originality/value

There is a dearth of research on vibration characteristics of rotor system support by journal bearing combining HSFD and MMD. Moreover, the active oil pressure control is implemented to improve the stability of rotor system.
Understanding the arena of smoldering crises: a longitudinal study of discursive struggles after implementing a new IT health care platform
Authors: Maier Carmen Daniela , Frandsen Finn , Johansen Winni
Published: September 2022

Purpose

The aim of this paper is to study the development of a smoldering crisis over time. The focus is on a nationwide news media and online news communication related to a smoldering crisis running in the Danish healthcare system since 2016: the problematic implementation of a large-scale electronic health record (EHR), technology entitled Sundhedsplatformen (SP), in the hospitals of the capital region of Denmark.

Design/methodology/approach

Based on insights from crisis communication theories and in particular rhetorical arena theory (RAT), traces of SP smoldering crisis and patterns of discursive strategies are identified and explained from a longitudinal perspective to explain the communicative complexity that characterizes this smoldering crisis. To build an understanding of how this smoldering crisis is perceived, followed and kept alive, an analysis of (de)legitimation discursive strategies employed strategically by various actors and voices in news articles is conducted in relation to four communicative themes: issue identification, warnings, blame attribution and potential solutions.

Findings

It has been found that a legitimacy deficit emerges communicatively through specific (de)legitimation strategies during this smoldering crisis. New insights into RAT (Frandsen and Johansen, 2017) are also provided.

Practical implications

This study is not only of theoretical relevance, but it is also of practical relevance for public relation professionals who aim to identify characteristics of starting smoldering crises as well as to find strategic responses to the ongoing challenges and the developing over time of smoldering crises.

Originality/value

New insights into RAT (Frandsen and Johansen, 2017) are provided.
Actions speak louder than words – strategic communication and (un)intentional signalling: a semio-pragmatic taxonomy
Authors: Palmieri Rudi , Rocci Andrea
Published: September 2022

Purpose

The article tackles the under-defined notion of communication in strategic communication research and elaborates a taxonomy of semiotic processes, which distinguishes different types of communicative and signalling events. The purpose is to offer an improved analysis of the processes by which meaning emerges from strategic communication situations.

Design/methodology/approach

The proposed taxonomy is based on a conceptual framework combining semiotics, linguistic pragmatics and signalling theory. Several real cases of strategic communication are analysed to exemplify the taxonomy.

Findings

Different sub-types of signalling events are highlighted and explained. The communicative function of performed behaviours (i.e. when actions speak and do it louder than words) depends on how informative and communicative intentions are managed by the message source and inferentially interpreted by different receivers. It is suggested that the ways in which meaning is signalled can be best understood with an argumentative perspective that foregrounds the inferential processes of persuasion, interpretation and decision-making. The limitations of the transmission vs. ritual and the one-way vs. two-way theories of strategic communication are highlighted.

Originality/value

The article discusses strategic communication events with the under-considered perspective of communication theories in the fields of semiotics and pragmatics. Signalling phenomena are interpreted from a communicative viewpoint, emphasising the argumentative dynamics that constitute them.
Comparison of volatility and mean reversion among developed, developing and emerging countries
Authors: Arsalan Tazeen , Chishty Bilal Ahmed , Ghouri Shagufta , Ansari Nayeem Ul Hassan
Published: September 2022

Purpose

This research paper aims to analyze the stock exchanges of developed, emerging and developing countries to investigate the volatility in stock markets and to evaluate the rate of mean reversion.

Design/methodology/approach

The stock exchanges included in the research are NASDAQ, Tokyo stock exchange, Shanghai stock exchange, Bombay stock exchange, Karachi stock exchange and Jakarta stock exchange. Secondary daily data from Bloomberg are used to conduct the research for the period from January 2011 to December 2018. Generalized autoregressive conditional heteroskedasticity (GARCH) (1,1) model was applied to examine volatility and the half-life formula was used to calculate mean reversion in days.

Findings

The research concluded that all the stock exchanges included in the research satisfy the assumptions of mean reversion. Developing countries have the lowest volatility while emerging countries have the highest volatility which means that the rate of mean reversion is fastest in developing countries and slowest in emerging countries.

Research limitations/implications

Future studies can determine the reasons for fastest rate of mean reversion in developing countries and slowest rate of mean reversion in emerging countries.

Practical implications

Developing countries show the lowest mean reversion in days while the emerging countries show the highest mean reversion in days indicating that developing countries take less time to revert to their mean position.

Originality/value

The majority of previous studies on univariate volatility models are mostly on applications of the models. Only a few researchers have taken the robustness of the models into account when applying them in emerging countries and not in developed, developing and emerging countries in one place. This makes the current study unique and more rigorous.
The interplay between digital social capital and family-owned SME performance: a study of social media business networks
Authors: Tiwasing Pattanapong , Kim Yoo Ri , Sawang Sukanlaya
Published: September 2022

Purpose

This paper aims to examine the relationship between being members of social media business networks and SME performance by comparing business performance between family-owned SMEs that are members and non-members of social media business networks.

Design/methodology/approach

The analysis empirically draws on cross-sectional data of 9,292 English and Welsh family-owned SMEs from the UK's Government Small Business Survey 2015. Propensity Score Matching (PSM) is applied to control for selection bias and differences in firm characteristics before comparing business performance, measured in terms of annual turnover, sales-growth intention and innovation between family-owned SMEs that are members and non-members of social media business networks.

Findings

The findings show that family-owned SMEs that are members of social media business networks are more likely to have higher prior turnover and to grow their sales than non-members. Also, they are more likely to report being innovative in products and processes than non-members. The empirical results acknowledge the importance of online business networks and digital social capital on enhanced family-owned business performance.

Originality/value

This paper is the first to explore the comparative analysis of business performance between family-owned SMEs that are members and non-members of social media business networks. This paper is important for the development of family business research by providing a comprehensive evidence-based analysis regarding the importance of online business networks to improve family-owned business performance, given the significant contribution of digital business activities to the UK economy.
Abuse of enduring power of attorneys and real estate transactions in Australian courts
Authors: West Tracey , Drew Nicholas
Published: September 2022

Purpose

The purpose of this study is to highlight how people acting as Enduring Power of Attorney (EPoA) abuse their privilege in relation to real estate transactions through analysis of five court cases. This study thereby provides insight into how and why adult children cross the line into the realm of misconduct.

Design/methodology/approach

The approach involved a review of various court proceedings relating to elder financial abuse, and the synthesis of the important facts and judgements made that constitute unconscionable conduct, undue influence and passive acceptance of benefit. The cases selected focus on real estate transactions.

Findings

The research revealed some key commonalities and that property and living arrangements are the issues highly contested in courts for small estates.

Practical implications

The case review provides some critical findings that are valuable for wealth management professionals or managing an ageing person’s care and living arrangements. It provides practical insights for the importance of independent legal and financial advice when entering real estate transactions. The findings also inform real estate agent practice in helping to reduce elder financial abuse through robust checks if an Attorney is acting on behalf of a Principal. The authors also support improving EPoA guidance and professionalization to assist Attorney’s to carry out their duties with appropriate care.

Originality/value

A review of cases relating to EPoA in relation to real estate is novel and makes an important contribution to developing resources to educate Attorney’s and financial service professionals, including real estate agents.
Determining food attributes for measuring and evaluating a gastronomic destination's appeal to visitors
Authors: Soonsan Nimit , Phakdee-auksorn Panuwat , Suksirisopon Pornchai
Published: September 2022

Purpose

The research aims to determine local food attributes for measuring and evaluating that appeal tourists to the gastronomic city of Phuket, Thailand.

Design/methodology/approach

The first step is, the item generation, which includes an in-depth interview. Secondly, scale purification includes the exploratory factor analysis, which generates a preliminary factor structure. In the final step, scale validation, confirmatory component analysis is used to test the items and dimensions.

Findings

The 33 items organized into eight dimensions: food quality, authenticity, hygiene, interpersonal, novelty, service provider, foodservice place and value added for a creative city of gastronomy were demonstrated to be valid and reliable after a thorough development process.

Practical implications

The findings assist practitioners in recognizing the many aspects of local food attributes, as well as how destination managers can employ these factors to promote a destination.

Originality/value

This research contributes to the theoretical literature on a gastronomic creative city, with more research into the links between destination management and other important concepts. In terms of the outcomes of a creative city of gastronomy management, this study might serve as a reference for destination managers and travel suppliers.
Dyadic, network and ecosystem alliances: systematic literature review and research agenda
Authors: Krishna Ram
Published: September 2022

Purpose

Literature on strategic alliances (SAs) is large, diverse and growing. It needs synthesis and analysis for application and further research. Authors have also underlined the need for studies covering differences in structuring, situational application and management of alliances. This systematic literature review aims to cover dyadic, network and ecosystem (DNE) alliances with theory, context, characteristics and methodology (TCCM) methodology covering the life cycle stages of an alliance (pre-formation, formation and management) to uncover insights which inform practice and guide further research on this important subject.

Design/methodology/approach

This paper follows systematic literature review (SLR) methodology for research design and article selection and TCCM methodology for analysis. It also analyses the literature on DNE alliances using a nine-box matrix with DNE alliance forming one axis and three alliance lifecycle stages of pre-formation (alliance objectives), formation (alliance design and operationalisation) and post formation (alliance management) stages along the other axis.

Findings

Analysis indicates focus on individual firms and their own customer value proposition (CVP) in the dyadic and network alliances. Industries with fast-paced technological change benefit from loosely coupled alliances. Social context and social exchanges leading to collaboration and collective strengths mark network alliances, with a focus on knowledge creation and dissemination. Ecosystems focus on a collective CVP, which guides alliance behaviour. Ecosystem leadership guides this purpose through governance for sustained competitiveness. Negative consequences (dark side) of alliances can be mitigated by careful design, formation and management of DNE alliances.

Research limitations/implications

While literature has focussed on static view of alliances in their industry or social context, this literature review analyses alliances along the dyadic, network and ecosystem typology, thus providing a new lens to study alliances. The review also recognises that alliances evolve over their life-cycle stages and observes their progression through their lifecycle stages aids for fuller comprehension of their behaviour. Areas for future research in structuring, leadership, value co-creation and technological change set an agenda for future research.

Practical implications

Dynamic managerial capabilities are drivers of alliance performance. The analysis using the nine-box matrix allows managers to better appreciate the options that exist and the consequences of their actions. Situating their alliance in the appropriate box can allow managers better plan, operationalise and manage their own alliances.

Originality/value

This systematic review compares and contrasts DNE alliances in extant literature and through their lifecycle stages. Insights from TCCM analysis and the nine-box matrix provide unique contribution to both theory and practice in this large and growing domain.
Co-leadership to co-design in mental health-care ecosystems: what does it mean to us?
Authors: Rosen Alan , Holmes Douglas John
Published: September 2022

Purpose

This study aims to demonstrate how service providers, service users and their families should be able to share the co-leadership, co-auspicing, co-ownership, and co-governance, of a the mental health-care ecosystem, at every level, as it develops upwards and wider, in a process of inclusivity, conviviality and polyphonic discourse, via the overlapping phases of co-creativity, codesign, co-production, co-delivery, co-evaluation, co-research and co-replication, to achieve outcomes of co-communal or organisational well-being.

Design/methodology/approach

“Co-design” is shorthand code for encouraging multiple pathways and trajectories toward forming and sustaining a sparkling web or vibrant network of inclusive opportunities for stakeholder participation and a collaborative partnership in organizational development, in these circumstances, for more effective mental health services (MHSs).

Findings

In a co-design framework, all partners should be entitled to expect and “to have and to hold” an ongoing equal stake, voice and power in the discourse from start to finish, in a bottom-up process which is fostered by an interdisciplinary leadership group, providing the strong foundation or nutrient-rich and well-watered soil and support from which a shared endeavor can grow, blossom and generate the desired fruit in ample quality and quantity.

Originality/value

The authors should be working toward co-design and co-production of contemporary MHSs in a mental health-care ecosystem.
Empirical investigation of the impact of overload on the discontinuous usage intentions of short video users: a stressor-strain-outcome perspective
Authors: Ye Dingyu , Cho Dongmin , Chen Jianyu , Jia Zhengzhi
Published: September 2022

Purpose

This study focuses on perceived overload from environmental stimuli and individual psychology and behavioral interactions. It constructs a theoretical model with overload as the key stressor based on the stressor-strain-outcome (SSO) model. The authors argue that system feature overload (SFO), information overload, and social overload lead to two psychological strains: fear of missing out (FoMO) and fatigue among users of short video platforms, affecting their discontinuous usage intentions.

Design/methodology/approach

To test the hypotheses, the authors conducted a questionnaire survey on 412 users' short video platform usage and empirically tested the constructed model using the research tool SmartPLS 3.3.2.

Findings

The results of data analysis showed that most of the hypotheses were supported. Specifically, system feature overload, information overload and social overload all positively affected FoMO. However, SFO and information overload significantly affected fatigue. There was no significant relationship between social overload and fatigue. In addition, both FoMO and fatigue negatively influenced users' discontinuous usage intentions.

Originality/value

The current research on user behavior in information systems tends to focus on the influence in the positive direction and less on the negative direction. The research on discontinuous usage intention (DUI) is a very new research topic. This research studies the influencing factors of users' discontinuous behavior from the perspective of perceptual overload. It provides a unique view for future short video platform user behavior research, with significant theoretical contributions and essential practice for short video platform operators to improve services.
Effect of post-treatment on local mechanical properties of additively manufactured impellers made of maraging steel
Authors: Raghavan Srinivasan , Dzugan Jan , Rzepa Sylwia , Podany Pavel , Soh Norman , Hao Lim Jia , Khan Niaz
Published: September 2022

Purpose

This study aims to investigate the effect of the wall thickness, deposition orientation and two different post-processing methods on the local mechanical properties and microstructure of additively manufactured parts made of maraging steel. In order to examine the local properties of the build, miniaturized testing specimens were employed. Before application of small-sized specimens, their performance was verified.

Design/methodology/approach

The investigation was composed of two stages. As first, the part thickness, specimen size and orientation were studied on a laser-powder bed fusion (L-PBF) platform with deposited walls of various thicknesses made of maraging steel. Subsequently, the influence of different heat-treatment methods was investigated on the final product, i.e. impellers. The miniaturized and standard tensile tests were performed to investigate the local mechanical properties. The porosity, microstructures and fracture surfaces were analysed by X-ray-computed tomography, X-ray diffraction and scanning electron microscopy with electron backscatter diffraction.

Findings

The results revealed good agreement between the values provided by miniaturized and standard specimens. The thinnest parts produced had the largest pores and the highest scatter of elongation values. In these cases, also the sub-contour porosity was observed. Part thickness affected pores’ size and results repeatability but not total porosity. The two-step heat-treatment (solutionizing and age-hardening) exhibited the highest yield and ultimate tensile strength.

Practical implications

The microstructure and local mechanical properties were studied on L-PBF platform with deposited walls of various thicknesses. Subsequently, a detailed analysis was conducted on real components (impellers) made of maraging steel, commonly used in tooling, automotive and aerospace industries.

Originality/value

The broadly understood quality of manufactured parts is crucial for their reliable and long-lasting operation. The findings presented in the manuscript allow the readers better understanding of the connection between deposition parameters, post-processing, microstructure and mechanical performance of additive manufacturing-processed parts.
Tourism seasonality in small island developing states: evidence from Cyprus
Authors: Berjozkina Galina
Published: September 2022

Purpose

This paper adopts a thematic approach to a review of the literature relating to seasonality in small island developing states.

Design/methodology/approach

The paper uses a qualitative approach by retrieving data from academic sources and official public documents from the Government of Cyprus. Thematic analysis is employed to provide information in relation to the numerical aspects of seasonality through statistics and the steps taken by official tourism authorities to alleviate seasonality.

Findings

The findings reveal a significant seasonality problem in Cyprus, especially in the high season months and stagnation during the low season months in winter. This causes problems at the national economic level and results in unemployment. However, in recent years, the government has been trying to tackle the problem by rebranding the destination for all seasons, offering a broad spectrum of varied activities, such as niche, special interest, and cultural tourism.

Originality/value

The paper offers a review-based perspective on seasonality in small island developing states and discusses the merits of developing all-year-round tourism.
Russian Sanctions and the Banking Sector
Authors: Girardone Claudia
Published: September 2022

Western allies have imposed restrictive measures on Russian banks and threatened harsher sanctions on the finance sector since the annexation of Crimea in 2014. However, this did not impede sanctioned banks reporting record profits, nor deter Russia from invading Ukraine on 24 February 2022. Although the sanctions’ full effectiveness remains in question, the impact of Russia's invasion of Ukraine has not only caused a retreat of foreign banks from mainland Russia, but also ended the international ambitions of the largest Russian banks in Europe and beyond.
Real Men Don't Eat Quiche: Queer Food and Gendered Nationalism in the Late Twentieth‐Century USA
Authors: Cleves Rachel Hope
Published: September 2022

More than simply an international bestseller, Bruce Feirstein's satirical guidebook to masculinity, Real Men Don't Eat Quiche (1982), became a ubiquitous catchphrase of the 1980s. The title's success drew on a long tradition of gendered food nationalism in Anglo‐American culture that associated French cuisine with effete masculinity. During the 1970s, quiche in particular was seen as a quintessentially queer dish, served at brunch spots frequented by gay men. Through analysis of Feirstein's text, as well as the writings of James Beard, Craig Claiborne and others food journalists, this article examines how sexuality, gender, food and nationalism intersected in the late twentieth‐century Anglosphere.
Correlations of switch/sucrose nonfermentable complex mutations with clinical outcomes in advanced non–small cell lung cancer
Authors: Chang Geyun , Li Weihua , Bai Hua , Duan Jianchun , Wang Zhijie , Du Xinyang , Yu Ruofei , Wang Yaxi , Wang Minghao , Zhu Yixiang , Zhang Xue , Li Li , Wan Rui , Wang Jie
Published: September 2022

Background

The switch/sucrose nonfermentable complex mutations (SWI/SNF‐mut) are common in non–small cell lung cancer (NSCLC). However, the association of SWI/SNF‐mut with the clinical outcomes of immune checkpoint inhibitors (ICIs), particularly of epidermal growth factor receptor tyrosine kinase inhibitors (EGFR‐TKIs), has not been established.

Methods

We retrospectively collected data of patients at Cancer Hospital Chinese Academy of Medical Sciences. Patients with advanced NSCLC who received programmed cell death protein‐1 or programmed cell death ligand 1 (PD‐[L]1) inhibitors were included in cohort 1 and those with EGFR mutations (EGFR‐mutant) received EGFR‐TKIs monotherapy were included in cohort 2. Two reported Memorial Sloan‐Kettering Cancer Center (MSKCC) cohorts received immunotherapy alone used as the validation for cohort 1. We analyzed the relationship between SWI/SNF alterations and clinical outcomes in each cohort.

Results

In total, 1162 patients were included, of which 230 patients (19.8%) were identified as SWI/SNF‐mut with the most common genetic alterations being ARID1A (33.4%) and SMARCA4 (28.3%). In cohort 1 (n = 146), patients with co‐mutations of SWI/SNF and Kirsten rat sarcoma oncogene (KRAS) (SWI/SNFmutKRASmut, n = 18) had significantly prolonged progression‐free survival (PFS) (8.6 m vs. 1.9 m; hazard ratio [HR],  0.31; 95% confidence intervals [CI], 0.11–0.83; p = 0.032) to PD‐(L)1 inhibitors monotherapy, which was consistent with the MSKCC cohorts (not reach [NR] vs. 6.3 m; HR, 0.36, 95% CI, 0.15–0.82; p = 0.016). In cohort 2 (n = 205), ARID1A‐mut (n = 16) was associated with improved PFS after EGFR‐TKIs (20.6 m vs. 11.2 m; HR, 0.47, 95% CI, 0.27–0.94; p = 0.023).

Conclusions

In advanced NSCLC, patients with SWI/SNFmutKRASmut seem to benefit more from ICIs. Furthermore, ARID1A‐mut may provide a protective effect to EGFR‐TKIs in EGFR‐mutant patients. However, this is a retrospective single‐institution analysis that requires further validation by large prospective studies.
Expert consensus on the diagnosis and treatment of NTRK gene fusion solid tumors in China
Authors: Xu Chunwei , Si Lu , Wang Wenxian , Li Ziming , Song Zhengbo , Wang Qian , Liu Aijun , Yu Jinpu , Fang Wenfeng , Zhong Wenzhao , Wang Zhijie , Zhang Yongchang , Liu Jingjing , Zhang Shirong , Cai Xiuyu , Liu Anwen , Li Wen , Zhan Ping , Liu Hongbing , Lv Tangfeng , Miao Liyun , Min Lingfeng , Chen Yu , Yuan Jingping , Wang Feng , Jiang Zhansheng , Lin Gen , Pu Xingxiang , Lin Rongbo , Liu Weifeng , Rao Chuangzhou , Lv Dongqing , Yu Zongyang , Lei Lei , Li Xiaoyan , Tang Chuanhao , Zhou Chengzhi , Zhang Junping , Xue Junli , Guo Hui , Chu Qian , Meng Rui , Wu Jingxun , Zhang Rui , Hu Xiao , Zhou Jin , Zhu Zhengfei , Li Yongheng , Qiu Hong , Xia Fan , Lu Yuanyuan , Chen Xiaofeng , Ge Rui , Dai Enyong , Han Yu , Pan Weiwei , Luo Jiancheng , Jia Hongtao , Dong Xiaowei , Pang Fei , Wang Kai , Wang Liping , Zhu Youcai , Xie Yanru , Lin Xinqin , Cai Jing , Wei Jia , Lan Fen , Feng Huijing , Wang Lin , Du Yingying , Yao Wang , Shi Xuefei , Niu Xiaomin , Yuan Dongmei , Yao Yanwen , Huang Jianhui , Zhang Yinbin , Sun Pingli , Wang Hong , Ye Mingxiang , Wang Dong , Wang Zhaofeng , Wan Bing , Lv Donglai , Wei Qing , Kang Jin , Zhang Jiatao , Zhang Chao , Yu Genhua , Ou Juanjuan , Shi Lin , Li Zhongwu , Liu Zhefeng , Liu Jing , Yang Nong , Wu Lin , Wang Huijuan , Jin Gu , Yang Liu , Wang Guansong , Fang Meiyu , Fang Yong , Li Yuan , Wang Xiaojia , Zhang Yiping , Ma Shenglin , Wang Biyun , Zhang Xiaotian , Song Yong , Lu Yuanzhi
Published: September 2022

Gene fusions can drive tumor development for multiple types of cancer. Currently, many drugs targeting gene fusions are being approved for clinical application. At present, tyrosine receptor kinase (TRK) inhibitors targeting neurotrophic tyrosine receptor kinase (NTRK) gene fusions are among the first “tumor agnostic” drugs approved for pan‐cancer use. Representative TRK inhibitors, including larotrectinib and entrectinib, have shown high efficacy for many types of cancer. At the same time, several second‐generation drugs designed to overcome first‐generation drug resistance are undergoing clinical development. Due to the rarity of NTRK gene fusions in common cancer types and technical issues regarding the complexity of fusion patterns, effectively screening patients for TRK inhibitor treatment in routine clinical practice is challenging. Different detection methods including immunohistochemistry, fluorescence in situ hybridization, reverse transcription‐polymerase chain reaction, and (DNA and/or RNA‐based) next‐generation sequencing have pros and cons. As such, recommending suitable tests for individual patients and ensuring the quality of tests is essential. Moreover, at present, there is a lack of systematic review for the clinical efficacy and development status of first‐ and second‐generation TRK inhibitors. To resolve the above issues, our expert group has reached a consensus regarding the diagnosis and treatment of NTRK gene fusion solid tumors, aiming to standardize clinical practice with the goal of benefiting patients with NTRK gene fusions treated with TRK inhibitors.
Integrated spatial models foster complementarity between monitoring programmes in producing large‐scale bottlenose dolphin indicators
Authors: Lauret V. , Labach H. , Turek D. , Laran S. , Gimenez O.
Published: September 2022

Over the last decades, large‐scale ecological projects have emerged that require collecting ecological data over broad spatial and temporal coverage. Yet, obtaining relevant information about large‐scale population dynamics from a single monitoring programme is challenging, and often several sources of data, possibly heterogeneous, need to be integrated. In this context, integrated models combine multiple data types into a single analysis to quantify the population dynamics of a targeted population. When working at large geographical scales, integrated spatial models have the potential to produce spatialized ecological estimates that would be difficult to obtain if data were analysed separately. In this study, we illustrate how spatial integrated modelling offers a relevant framework for conducting ecological inference at large scales. Focusing on the Mediterranean bottlenose dolphins (Tursiops truncatus), we combined 21,464 km of photo‐identification boat surveys collecting spatial capture–recapture data with 24,624 km of aerial line transect following a distance sampling protocol. We analysed spatial capture–recapture data together with distance sampling data to estimate the abundance and density of bottlenose dolphins. We compared the performances of the distance sampling model and the spatial capture–recapture model fitted independently to our integrated spatial model. The outputs of our spatial integrated models inform bottlenose dolphin ecological status in the French Mediterranean Sea and provide ecological indicators that are required for regional‐scale ecological assessments like the EU Marine Strategy Framework Directive. We argue that integrated spatial models are widely applicable and relevant to conservation research and biodiversity assessment at large spatial scales.