bluuebunny/crossref_metadata_2025 huggingface dataset:
Should the GCM2 gene be tested when screening for familial primary hyperparathyroidism?
Authors: Coppin Lucie , Dufosse Margaux , Romanet Pauline , Giraud Sophie , North Marie-Odile , Cardot Bauters Catherine , Borson-Chazot Françoise , Duchesne Laurence , Métallo Mélanie , Lovecchio Tonio , Barlier Anne , Odou Marie-Françoise
Published: October 2019

Objective

Primary hyperparathyroism (PHPT) is a disease with either sporadic or inherited presentation. Germline mutations responsible for this disease can be found in different genes, the most frequently involved being MEN1, CDC73 = HRPT2 and CASR. During the last few years, new genes have been described as responsible for the development of PHPT such as GCM2. These genes are not systematically included in PHPT genetic screening yet. The aim of this work was to assess the importance of GCM2 genetic analysis in PHPT to determine if this gene should be included in gene panel investigated for this disease.

Design and methods

The TENGEN network (French Oncogenetic Network of Neuroendocrine Tumors) collected and interpreted allelic variants according to the clinical characteristics of the GCM2-positive patients identified through genetic testing performed in French laboratories (713 patients with PHPT).

Results

From 713 patients with PHPT included in this study, 85 (6.6%) carried at least one GCM2 variant. A total of 12 variants classified as uncertain significance or likely pathogenic were reported in 47 patients. Their mean age at PHPT diagnosis was 49 years. Additionally, the investigation of a large family showed that GCM2 variants could be associated with low penetrance.

Conclusion

We provide a description and interpretation for GCM2 variants identified in a French population. We suggest that this gene should be included in genetic screening of patients with PHPT and propose the follow-up of asymptomatic patients carrying such variants for calcemia.
Forecasts of Russian Regions in the Conditions of Economic Sanctions
Authors: Klimanov Vladimir , Vardanyan Vardan
Published: October 2019

The purpose of this article is to study the dependence of the impact of international economic sanctions in the forecasts of entities of the Russian Federation on their economic characteristics. The international sanctions which were introduced by foreign states for the Russian Federation have a significant impact on regional economy. In the present circumstances regional economic forecasts should take into account the specificity, condition and possible threats of the external economic environment. The current regional documents of economic forecasting are a stable basis for regional strategies which in their turn ensure the implementation of integrated social and economic planning.
The authors conduct the analysis of the way how economic sanctions are taken into account in regional forecasts.
The researchers study namely forecasts of social and economic development of the Russian Federation entities for long term and short term periods and budget forecasts for a long term period as well. The paper analyzes legal acts and methodological documents for the development and approval of these documents. The authors compile regional ratings according to the following indicators: amount of foreign direct investments; export of goods; volume of shipped goods, work performed by domestic manufacturing industries; average rating positions.
The researchers provide an assessment of the way the sanctions are taken into account in the documents according to the suggested variants: the sanctions are not taken into account and are not reflected in the documents; the sanctions are mentioned in the forecast and are taken into account; the impact from the sanctions is taken into account and the response of Russia is shown. On the basis of the analysis the authors make conclusions on the impact of regional economic performance on mentioning foreign economic sanctions in the corresponding economic forecasts. The paper shows that the inclusion of the influence of economic sanctions in the mentioned strategic documents depends on the quality of the documents under analysis and their inclusion into the strategic documents has a random nature.
Developing Ecosystems of Social Innovation in the Context of Creating Regional Innovative Subsystems
Authors: Soloveva Tatiana
Published: October 2019

Innovative economic development is one of the priorities of state policy at both federal and regional levels. At the same time, special attention is paid to the formation of regional innovative subsystems, since effective functioning of the national innovative system is not possible without their development and interaction. The article focuses on the main problems of creating regional innovative subsystems in Russia with an emphasis on forming the ecosystems of social innovation. This issue is quite relevant as technological innovations prevail among Russian studies devoted to regional economics and management practices. At the same time, global experience shows that social innovations can make a significant contribution to solving many issues of economic and social development of the territories and regional development growth. In this regard, the author proposes to identify the regional socio-innovative subsystem within the framework of the regional innovative subsystem and to analyze its development from the point of view of the ecosystem approach. The article presents an overview of key issues of implementing social innovations and creating social innovative ecosystems in Russia dealing with both theoretical and practical issues of the topic under consideration (underdevelopment of theoretical and methodological basis of research on social innovations, underdevelopment of existing legislation in the sphere of social innovations, lack of statistical records and information about social innovations, low level of social activity of the population). The author emphasizes the main drivers and barriers to the development of social innovations and suggests the main directions of solving the identified problems in the context of developing regional social and innovative ecosystems.
Isolation of two-dimensional E-fields in the excitation equations for hollow waveguides
Authors: Kuraev A , Koronovskii A , Kurkin S , Rak A , Rempen I , Badarin A , Hramov A
Published: October 2019

The traditional excitation equations of the Vainshtein waveguide excitation theory based on presenting the field excited by extraneous sources as a sum of TE and TM eigenwaves of the hollow waveguide, which transversal components form the complete basis in the class of the transversal vectors of a waveguide section. However, in the excitation sources area (longitudinal sonde, electron beam) the waveguide is not hollow and the potential transverse electric field appears in this area. The transversal electric field completes the basis of TE and TM waves. This is not taken into account in the traditional excitation equations. In this paper, the necessary correction of the excitation equations in the sources area is obtained.
Detection of signals with the orthogonal basis of the Gauss-Hermite functions
Authors: Balakin D , Churkin S , Shtykov V
Published: October 2019

The analysis of the shape and parameters of signals is a key part of the signal processing. As a rule in practicable task, the shape of the input signal is known and identification of the unknown parameters (amplitude, duration, location or time of arrival, etc.) is required, then the dynamics of the signal sequence in the process under study is important as well. Thus, the problem is the most reliable detection of the desired signal on the background of random noise and the most accurate measurement of its parameters. It is known that a solution of such problems concerns optimal filtering. The main abstract of the method of the signal detection, based on orthogonal basis functions of the Gauss-Hermite functions, is described. The method is founded on the matched filtering principles, it allows tracking not only the dynamics of the signal under investigation, but also its local features, which provide additional diagnostic information. The verification method is carried out on a real signal of a phase measuring complex. The signal represents a sequence of pulses as a mixture component of the respiratory and cardiac activity of a medical patient.
Improving the efficiency of data transmission systems by signal basis orthogonalization
Authors: Degtyaryov Alexander , Afonin I , Miryanova V
Published: October 2019

It is shown that from the equidistant biased impulse response of normalized filters one can create a quasi-orthogonal weight basis. It is concluded that when certain requirements are carried out the conversion of a normalized filter into a low-pass filter with a predetermined cutoff frequency or into a bandpass filter with a center frequency and a bandwidth given does not alter the orthogonality conditions. It is suggested to use the signals received by the specified basis for data transmission. The dependence of the maximum speed of data transmission in the proposed system on the filter order forming a communication channel, the minimum attenuation of its impulse characteristics and its bandwidth at 3 dB, is obtained. Two options for construction of such signals receiver are indicated. It is shown that in the conditions of inter-symbol interference the proposed method of systems constructing offers better noise immunity in comparison with the classical approach.
About eponyms in infocommunications and radio technologies terminology
Authors: Yermolov P
Published: October 2019

Eponimy problems in terminology of infocommunications and radio technologies are considered for the first time. Consideration of a linguistic aspect includes the analysis of 169 domestic publications in 27 directions of researches and allocation of medicine as a direction which concerns nearly half of all publications. It is supposed that the use of the term "eponym" became widely used by linguists in the last third or a quarter of the 20th century, as they adapted existing practices to assign personal names existing in medicine to a wide range of medical terms. Two types of dictionaries of the medical terms-eponyms differing in volume and structure are considered and analyzed. 64 eponyms-anthroponyms and one eponym-toponym are allocated from the standard programs of the speciality "Radio Engineering" (1984 version) as an example. The full name of the researcher, years of life, the country and disciplines using eponyms are established for eponyms-anthroponyms. It is established that the main "supplying countries" of eponyms-anthroponyms are the USA - 18, Great Britain - 11, France - 11, Germany - 10 and Russia - 6 eponyms. Drawn conclusions prove the need of continuation of researches in order to include: preparation of separate publications concerning forgotten or underexplored personalia, and preparation of the dictionary, which glossary has to correspond to modern programs of training of specialists. Results of such researches will promote formation of such competences as ability validly and delicately use historical heritage and ability to carry out the activity on the basis of complete system scientific outlook with use of knowledge in the field of history of science and equipment.
Global navigation satellite systems in the geopolygon structure
Authors: Volvach A , Kurbasova G
Published: October 2019

The modern automation system is unthinkable without the use of the accurate time source. Although most systems currently use the GPS signals, it is obvious that the GLONASS system will be used in the Russian Federation in the near future. The greatest interest in the existence of the GLONASS concerns the joint use of the GLONASS and the GPS. The time offset between the GPS and the GLONASS is an important parameter in the processing of combined GPS/GLONASS measurements. High-precision evaluation system of the time difference can provide centimeter accuracy positioning. The present paper concerns the analysis results for the variable component C1 of GLONASS timescale offset values relative to the scale UTC, TAI for the period of 2009-2013.
Coherent pulsed UHF transmitter of aerological radar
Authors: Ivanov V , Kudinov S , Gusev A , Plohih O
Published: October 2019

The paper presents the development results concerning a powerful (800 W) coherent pulsed transmitter of an upper-air radar system for atmosphere radio sounding with programmable tuning of the carrier frequency radio pulses in 1680 MHz range to provide a slant range measurement up to an upper-air radiosonde on the basis of a superregenerative transceiver (SRT). Field LDMOS transistors of 2П9110 type are combined into pallets to obtain high output power in amplification stages of the microwave transmitter. The results of measurements of microwave transmitter basic parameters are presented.
Design of ultra-wideband long-term RF-signal delay devices
Authors: Belkin M , Klyushnik D , Toporkov N
Published: October 2019

Based on the previous results for investigation of various retarding materials for super-wide bandwidth long-term delay lines [1], the principles of design and the achieved parameters of commercially produced and developed RF-signal delays with the use of fiber-optic circuits were studied. Considering the shortcomings of existing devices, the principles of optimization and design of fiber-optic delay lines for next generation devices: (1) a distributed structure of low-power emitters based on dense wavelength division multiplexing, (2) a multicore optical fiber as a retarding medium, (3) two-stage processing including an optoelectronic repeater unit, and (4) an optical recirculation time-delay circuit were proposed. Experimental verification of the proposed principles has shown their feasibility, efficiency and the opportunity to significantly improve the energy consumption and weight-dimensional characteristics, to increase the maximum delay time up to the millisecond range with a step in the microsecond range, also to improve the quality and flexibility of the delay device.
Seasonal fluctuations in observations of solar energy parameters and Earth deformations in Crimea
Authors: Kurbasova Galina S , Volvach Alexandr
Published: October 2019

The effects of regular solar and geodynamic oscillations in satellite data on the insolation of earth falling on the surface at Kara-Dag point for the period from 1983.5 to 2005.5 have been discovered. The parameters of the sinusoidal model of seasonal fluctuations are determined. Possible reasons for the increase in the amplitude of this oscillation are discussed. With the help of the wavelet transform, the spectral structure and spatial-temporal changes in the satellite data on the insolation of the incident on the earth's surface at Kara-Dag and local un modeled deformations of the earth at the point of Katsiveli were investigated. In the interferometric radio time series of observations of additions to the deformations of the earth's surface, carried out in the framework of international projects at the Simeiz station (Katsiveli), periodic components were found and modeled. The amplitude of the most significant seasonal component is 3.34 mm. Using the time-frequency wavelet transform, information was obtained on the temporal localization and changes in the power and frequency of seasonal fluctuations in the data on the insolation of the earth falling on the Kara-Dag point for the period from 1983.5 to 2005.5 and in the data on local un modeled deformations of the earth in paragraph Katsiveli for the period from 1980 to 2014.
Investigation of the solar activity of the KRIM Solar Telescope solar service
Authors: Volvach Alexandr E , Yakubovskaya Inna V
Published: October 2019

Radio astronomy diagnostic complex based on the RT-22 radio telescope and three small radio telescopes combined into the KRIM Sun Service is located at 330 59 '30'' E longitude and 440 23 '52'' N latitude. The KRIM Sun Service conducts observations of the Sun in monitoring mode and alerts. The complex is integrated into the World Service for Solar Activity Research, and the daily data is stored in real time in digital form and posted on the sites of the World Sun Service, which includes 14 ground stations in cooperation with orbital observatories. During the minimum period of the 11-year solar activity cycle from September 6 to 10, 2017, KRIM Sun Service radio telescopes recorded a number of strong solar radio bursts in the active region NOAA 12673. The information obtained correlates well with data from other ground-based and satellite observatories, such as RSTN (Network Solar Radio Telescopes) and GOES (Geostationary Operational Satellite for Surrounding Space). This confirms the high quality and accuracy of the KRIM Solar Service radio telescopes.
Contribution of Professor G. S. Sharygin (1934-2018) in the study of radio wave propagation
Authors: Denisov Vadim P , Yermolov Pavel
Published: October 2019

G. S. Sharygin - the founder and the director of the scientific school of radio engineering systems analysis and synthesis the Research Institute of Radio Engineering Systems of TUSUR, academician of the International Academy of Sciences of Higher School and the Academy of Engineering Sciences of the Russian Federation, a member of the Bureau of the Scientific Council of the Russian Academy of Science on the complex problem of radio wave propagation, a IEEE member , the Chairman and a member of the dissertation councils, the Honored Scientist of the Russian Federation. He was awarded several medals of the Federation of Cosmonautics of Russia, the Medal of the Academy of Engineering Sciences of the Russian Federation “For the contribution to the development of engineering sciences,” the sign “Inventor of the USSR”, marked by the letters and gratitude of the University, city and regional administrations, the Council rectors of universities of Tomsk region as well as Russian enterprises. The article provides biographical information, a brief scientific biography, citations from unpublished memories of G. S. Sharygin, reflects the fact of his interest in issues of the history and methodology of science and technology, as well as participation in the work of the 2nd Region 8 IEEE Conference on the History of Telecommunications (Madrid, 2010) and in the work of the sections “History of development of radio technologies and telecommunications, the history and methodology of science and technology” of the CriMiCo conference (Sevastopol, 2014 and 2015).
A coordenação do cuidado na qualidade da assistência à saúde da mulher e da criança no PMAQ
Authors: Cruz Maria Jesus Barreto , Santos Alaneir de Fátima dos , Araújo Lucas Henrique Lobato de , Andrade Eli Iola Gurgel
Published: October 2019

Resumo: O objetivo foi identificar a associação do atributo coordenação do cuidado com a qualidade da assistência à saúde da mulher e da criança na atenção primária à saúde no Brasil. Foi realizado estudo transversal, baseado em dados de 30.523 equipes que participaram do Programa de Melhoria do Acesso e da Qualidade da Atenção Básica em 2013. Foi feita análise de regressão logística. A variável dependente foi o nível de qualidade da assistência à saúde da mulher e da criança, e a independente, o nível de coordenação do cuidado. A análise multivariada considerou variáveis que apresentaram p < 0,05. O ajuste do modelo foi realizado pelo teste de Hosmer-Lemeshow. Foram avaliados os resultados de 28.056 equipes que realizaram atividade de coordenação e de assistência à saúde da mulher e da criança simultaneamente. No Brasil, o maior percentual das equipes apresentou nível baixo de coordenação (68,5%). Os níveis mais altos de coordenação foram encontrados no estrato 6 (57,2%) e os mais baixos no estrato 1 (78,5%). Dentre as regiões, a Norte apresentou o maior percentual de equipes com baixo nível de coordenação (89,1%), e a Sudeste, o maior percentual com alto nível (37,6%). Para o nível de qualidade da assistência à saúde da mulher, 70,5% das equipes estava com baixo nível e, na saúde da criança, 63,5% com alto nível. Possuir alto nível de coordenação está associado a ter alto nível de qualidade da assistência, tanto na saúde da mulher (OR = 11,85) como na saúde da criança (OR = 8,79). Foi possível constatar um predomínio de baixos níveis de coordenação do cuidado no Brasil, bem como baixos níveis de qualidade da assistência à saúde da mulher, refletindo a necessidade de ações coordenadas nessa área.
Chronic noncommunicable diseases multimorbidity and its association with physical activity and television time in a representative Brazilian population
Authors: Christofoletti Marina , Duca Giovani Firpo Del , Umpierre Daniel , Malta Deborah Carvalho
Published: October 2019

Abstract: Lifestyle behaviors need to be more explored within the context of chronic noncommunicable disease (NCD) multimorbidity. This study aimed to investigate the association of multimorbidity with physical activity and sedentary behavior in a representative Brazilian population (n = 52,929). A cross-sectional survey (VIGITEL in the Portuguese acronym) was conducted in 2013 in the 27 Brazilian federal units. Multimorbidity is defined as the presence of two or more NCDs, that is, the outcome variable; and physical activity (commuting, domestic chores, leisure, and work domains) and sedentary behavior (television time < 2 hours/day and ≥ 2 hours/day) were the exposure variables. Poisson and multinomial logistic regressions (odds ratio - OR) stratified by age and their respective 95% confidence intervals were used, adopting a significance level of 5%. Among 37,947 adults, the presence of three chronic diseases was less frequent in subjects active in the work domain (OR = 0.60) and more frequent among those with longer daily television time (OR = 1.25). The presence of four diseases was less frequent in subjects active in the commuting (OR = 0.52) and work (OR = 0.42) domains. Among 14,982 older adults, the presence of two, three, and four chronic diseases was consistently more frequent in those with longer daily television time (OR = 1.33; 1.55 and 1.93, respectively). Finally, interactions between total physical activity level and daily television time were statistically significant in the multimorbidity in both age groups. Physical activity and sedentary behavior are associated with multimorbidity and should be considered independent factors for health promotion and for the treatment of patients with multimorbidity.
Barreiras de acesso aos serviços em cinco Regiões de Saúde do Brasil: percepção de gestores e profissionais do Sistema Único de Saúde
Authors: Oliveira Ricardo Antunes Dantas de , Duarte Cristina Maria Rabelais , Pavão Ana Luiza Braz , Viacava Francisco
Published: October 2019

Resumo: O objetivo foi analisar as barreiras de acesso aos serviços de saúde existentes em cinco Regiões de Saúde do Brasil. Foram analisadas as respostas obtidas a partir da aplicação de questionários semiestruturados a gestores, prestadores e, em número mais restrito, a profissionais de saúde do Sistema Único de Saúde, tendo como referência as dimensões: Acessibilidade Geográfica, Disponibilidade e Aceitabilidade. Foram verificadas as especificidades em relação às barreiras de acesso nas regiões consideradas, já outras como a localização e tempo gasto no trajeto foram barreiras em quase todas elas quando foi considerado o cuidado ao acidente vascular cerebral. Quando à Disponibilidade, foram observadas questões relacionadas à insuficiência de médicos, tempo de espera prolongado e problemas relativos à integração, em todas as regiões. Quanto à Aceitabilidade, destacou-se a crença dos usuários de não possuir problemas de saúde. As Regiões de Saúde situadas no Sul e Sudeste do país registraram menor quantidade e diversidade de barreiras, revelando a persistência de desigualdades regionais. Embora os resultados não representem o conjunto do Brasil, permitem apontar questões relevantes sobre o processo de regionalização do sistema de saúde no país.
Multimorbidade e uso de serviços de saúde em indivíduos com restrição de atividades habituais: Estudo Pró-Saúde
Authors: Souza Ana Sara Semeão de , Faerstein Eduardo , Werneck Guilherme Loureiro
Published: October 2019

Resumo: O objetivo do estudo foi avaliar o uso de serviços de saúde e sua associação com diferentes medidas de multimorbidade. Trata-se de um estudo transversal aninhado a uma investigação longitudinal de funcionários técnico-administrativos no Município do Rio de Janeiro, Brasil: Estudo Pró-Saúde. Foram analisados dados coletados na fase 2 (2001-2002), sendo a população de estudo composta por 733 indivíduos que relataram restrição de atividades habituais por problemas de saúde nos 15 dias anteriores à coleta de dados. Busca por serviço de saúde (variável de desfecho) foi utilizada como proxy para uso de serviços de saúde. Multimorbidade foi avaliada por meio de contagem simples e de uma escala cumulativa (Cumulative Illness Rating Scale), gerando quatro variáveis de exposição: número de morbidades autorrelatadas, multimorbidade (2 ou mais morbidades), escore total e número de sistemas afetados. Nas análises estratificadas por sexo, foram utilizados modelos de regressão de Poisson com variância robusta ajustados por idade e escolaridade. Mulheres apresentaram em média valores mais altos para todas as medidas, e 51% foram classificadas com multimorbidade. Ter multimorbidade aumentou em 43% (IC95%: 1,11-1,84) a probabilidade de utilizar os serviços de saúde em homens, enquanto para as mulheres não houve associação estatisticamente significativa. Para os homens, a cada morbidade adicional, a probabilidade de utilizar serviço de saúde aumentou em 14% (IC95%: 1,05-1,24). Diferenças no uso de serviços de saúde e multimorbidade segundo sexo são evidentes. Conhecer tais padrões torna-se relevante para a prestação de um cuidado eficiente, coordenado e seguro para pessoas com multimorbidade.
Prevalência de transtornos mentais comuns e fatores associados em moradores da área urbana de São Paulo, Brasil
Authors: Santos Gustavo de Brito Venâncio dos , Alves Maria Cecilia Goi Porto , Goldbaum Moises , Cesar Chester Luiz Galvão , Gianini Reinaldo José
Published: October 2019

Resumo: Estudos realizados nos países em desenvolvimento descrevem um aumento progressivo dos transtornos mentais, com grandes repercussões sociais e econômicas. O presente estudo se propõe a analisar a prevalência dos transtornos mentais comuns (TMC) e seus fatores associados nos moradores da área urbana da cidade de São Paulo, Brasil. A partir dos dados levantados pelo Inquérito de Saúde do Município de São Paulo (ISA-Capital) de 2015, foi identificada a presença de TMC com a utilização do Self-Reporting Questionnaire (SRQ-20). A associação de TMC com as variáveis sociodemográficas e de condições de saúde foi analisada pela frequência relativa, corrigida pelos respectivos pesos decorrentes de uma amostragem de conglomerados, estimando-se a prevalência e intervalos de 95% de confiança (IC95%) em cada situação e avaliando-se a significância da associação pelo qui-quadrado corrigido pela distribuição F. A prevalência de TMC encontrada foi de 19,7% (IC95%: 18,2-21,4), sendo maior nas seguintes categorias: mulheres (24,3%); pessoas com 60 anos ou mais (25,3%); praticantes da umbanda/candomblé (37,8%); viúvos (30,4%); quem nunca frequentou a escola (31,4%); inativos/desempregados (28,3%); e quem possuía renda familiar de até um salário mínimo (28,8%). Em relação às variáveis de condição de saúde, a prevalência de TMC foi maior nos indivíduos que referiram: morbidade nos últimos 15 dias (36,9%); deficiência física (21,6%); deficiência mental ou intelectual (44,4%); problema emocional ou mental (48,9%); cefaleia (33,63%); e nos portadores de uma ou mais doenças crônicas (24,1%). As informações desta pesquisa reafirmam a relevância da prevalência de TMC assim como sua associação com os grupos sociais mais vulneráveis, o que reforça a necessidade da implementação de medidas públicas de saúde mental.
Experimentos de Calorimetria em Cursos Universitários
Authors: Cosentino Mauro Rogerio , Rios Lucas
Published: October 2019

Resumo Neste trabalho investigamos em detalhes o experimento de calorimetria tipicamente realizado em cursos universitários. A motivação foi a consistente ocorrência de problemas na determinação por parte dos(as) estudantes do calor específico de uma peça de teste, muitas vezes obtendo-se valores negativos. Exploramos diversas variações do método que chamamos de “padrão” que consiste em testar medir o calor específico de uma peça metálica que é colocada para entrar em equilíbrio térmico com uma amostra de água dentro de um calorímetro simples. Além deste, exploramos um método alternativo baseado no uso do efeito Joule. Os resultados indicam que uma das variações do método padrão fornece os melhores resultados. O método alternativo, contudo, obteve resultados melhores que outras variações do método padrão além de apresentar uma maior riqueza na exploração de conceitos físicos e de análise de dados.
Poéticas do dilaceramento e da desolação: Bernardo Carvalho e Sergio Chejfec
Authors: Thomaz Paulo César
Published: October 2019

Resumo Este trabalho consiste em uma análise de como as narrativas contemporânea brasileira e argentina, especificamente os romances Teatro (1998), do escritor brasileiro Bernardo Carvalho, e Los incompletos (2004), do argentino Sergio Chejfec, ficcionalizam diferentes poéticas da experiência contemporânea, com ênfase principalmente na impossibilidade e nos obstáculos em transformar o momento vivido em matéria narrativa.
Representação feminina na narrativa infantojuvenil brasileira contemporânea
Authors: Silva Leda Cláudia da
Published: October 2019

Resumo A partir de ampla pesquisa acerca do perfil das personagens da narrativa infantojuvenil brasileira contemporânea, este artigo investiga a representação feminina na literatura voltada para o público em questão. Pretende-se refletir acerca da construção do papel feminino, numa tentativa de identificar e problematizar questões relacionadas à ausência de representação, ao estereótipo, ou, ainda, à possibilidade de uma construção literária da identidade feminina de forma múltipla e representativa. As narrativas analisadas foram retiradas de acervo selecionado e distribuído pelo Ministério da Educação para escolas públicas do Brasil, por meio do Programa Nacional Biblioteca da Escola. Dentre as narrativas, duas serão investigadas mais detidamente: Por que meninos têm pés grandes e meninas têm pés pequenos?, de Sandra Branco, e Amanhecer esmeralda, de Ferréz.
Perspectivas e práticas de apoio educativo aos alunos com transtornos da linguagem em Portugal
Authors: Cruz-Santos Anabela , Costa Sónia Susana da Silva , Fernandes Raquel Maria Silva , Sapage Sara Pereira
Published: October 2019

RESUMO Objetivo Contribuir para o conhecimento das perspectivas e práticas de apoio educativo aos alunos com transtornos da linguagem em contextos inclusivos em Portugal. Método Após revisão da bibliografia sobre o tema, foi elaborado um questionário, posteriormente aplicado a 123 professores do ensino regular. Para a análise dos dados recolhidos, foi realizada uma análise estatística descritiva e inferencial das variáveis dependentes, utilizando testes paramétricos. Resultados A análise descritiva revela que a maioria dos professores conhece o conceito de transtornos da linguagem e considera importante compreender o desenvolvimento da linguagem ao lidar com alunos com essa problemática. No entanto, mais da metade dos inquiridos acha que não possui formação nem informações suficientes acerca da aquisição e do desenvolvimento da linguagem e também não concorda que possua competências suficientes para contribuir para a identificação de alunos com transtornos da linguagem. Os resultados relativos à análise inferencial revelam diferenças estatisticamente significativas no que diz respeito ao gênero, ao tempo de serviço e ao distrito. Os resultados obtidos demonstram boas qualidades métricas no que se refere à consistência interna. Conclusão Os resultados evidenciam a necessidade de formação e informação dos professores acerca da aquisição e do desenvolvimento da linguagem e, mais especificamente, dos transtornos da linguagem. Demonstram também que os professores do ensino regular poder-se-ão deparar com dificuldades no apoio educativo aos alunos com transtornos da linguagem e, particularmente, em delinear estratégias adequadas às suas necessidades, nomeadamente na elaboração de programas educativos individualizados.
Tradução e adaptação cultural e linguística da Adapted Borg CR10 for Vocal Effort Ratings para o português brasileiro
Authors: Camargo Mônica Regina Macedo Campolim , Zambon Fabiana , Moreti Felipe , Behlau Mara
Published: October 2019

RESUMO Objetivo Desenvolver a adaptação cultural e linguística da versão brasileira da Adapted Borg CR10 for Vocal Effort Ratings. Método O instrumento Adapted Borg CR10 for Vocal Effort Ratings foi traduzido para a língua portuguesa por duas fonoaudiólogas brasileiras bilíngues, cujas traduções foram compiladas em uma versão; posteriormente, foi realizada a retrotradução para o inglês por uma terceira fonoaudióloga brasileira, bilíngue, que não participou das etapas anteriores. Após a tradução e retrotradução, realizou-se a comparação dos itens com o instrumento original, sendo as discrepâncias modificadas por consenso, por um comitê composto por três fonoaudiólogos, chegando-se a uma única versão traduzida para o português brasileiro denominada Escala Borg CR10-BR adaptada para esforço vocal. Para a equivalência cultural da versão em português, a opção “não aplicável” foi acrescida na chave de respostas e 15 indivíduos disfônicos, com diagnóstico médico-otorrinolaringológico, responderam à Escala Borg CR10-BR adaptada para esforço vocal após a leitura das frases do protocolo de avaliação perceptivo-auditiva CAPE-V. Resultados No processo de tradução e adaptação cultural, não houve modificação e/ou eliminação de nenhuma das questões. A Escala Borg CR10-BR adaptada para esforço vocal reflete a versão original do inglês, com uma escala com variação de 0 a 10, sendo 0 “nenhum esforço vocal” e 10 o “máximo esforço vocal”. Conclusão A versão para o português brasileiro da Adapted Borg CR10 for Vocal Effort Ratings, intitulada Escala Borg CR10-BR adaptada para esforço vocal, apresenta equivalência cultural e linguística em relação ao instrumento original.
Apraxia de fala e atraso de linguagem: a complexidade do diagnóstico e tratamento em quadros sintomáticos de crianças
Authors: Catrini Melissa , Lier-DeVitto Maria Francisca
Published: October 2019

RESUMO Define-se apraxia de fala como a inabilidade de sequenciar os movimentos necessários a uma produção articulatória acurada, cuja explicação, tradicionalmente, é remetida a um déficit na programação motora da fala. Não é infrequente que clínicos de linguagem se defrontem com casos clínicos em que a inconsistência da fala coloca questões quanto ao diagnóstico diferencial entre apraxia e quadros considerados de linguagem. O reflexo desse impasse é observado na dificuldade em estabelecer uma direção de tratamento adequada ao problema apresentado. Neste trabalho, apresentamos o relato de um caso clínico em que tanto o diagnóstico quanto o tratamento mobilizam discussões a respeito da condição apráxica de fala na infância. Nas apraxias, partimos do reconhecimento de que o corpo colocado em evidência é aquele que ultrapassa sua configuração puramente orgânica. Consequências clínicas são retiradas da premissa de que o corpo humano é aquele cuja orelha pode escutar e a boca, falar, ou seja, é estrutura orgânica posta a funcionar de maneira especial pela incidência da música da linguagem a invocar o corpo falante.
Making Facts, Using Facts: Two Poetics of the Factual and One Theory of the Political
Authors: Tang Chenxi
Published: October 2019

In political thought, there is perhaps no more penetrating scrutiny of the significance of the factual than hannah Arendt's essay “Truth and Politics.” “Facts and events,” Arendt observes, are the “invariable outcome of men living and acting together.” As such, they “constitute the very texture of the political realm” (227). Concerning words and deeds of many actors, factual truth must be the basis for deliberations and opinions in the political space. “Freedom of opinion,” she continues, “is a farce unless factual information is guaranteed and the facts themselves are not in dispute. In other words, factual truth informs political thought just as rational truth informs philosophical speculation” (234). Yet facts are infinitely fragile things, for they occur in the ever-changing field of human affairs, “established through testimony by eyewitnesses—notoriously unreliable—and by records, documents, and monuments, all of which can be suspected as forgeries” (239). Facts can be manipulated, even denied outright by the powers that be. The lie, opposed to factual truth as error is to rational truth, represents a deliberate political action, since it aims “to change the world” (246).
Having a Coke with You Is Even More Fun Than Ideology Critique
Authors: Glavey Brian
Published: October 2019

This essay addresses the recent reception of Frank O’Hara's poem “Having a Coke with You” to examine the much-maligned concept of relatability as a potentially useful aesthetic category. If the reactions to it onTwitterandYouTubeare any indication, O’Hara's Coke poem has become his most famous piece, immensely popular both online and, in a strikingly different way, in the work of contemporary queer theorists. Whatever the context—queer utopian criticism, an anarchist journal, a wedding ceremony, or even an official Coca-Cola public-relations campaign—readers tend to respond to the poem's general mood rather than to its specific content. This reception speaks to the fact that O’Hara pursues what I would label a poetics of relatability: “Having a Coke with You,” like many other O’Hara poems, models ways of valuing art by relating it to other things and people. O’Hara explores this relational aesthetic by constantly negotiating between modes of reception that are self-reflective and modes that are social and intersubjective.
A prediction model for the gas permeability of geomaterials
Authors: Surya Sathee Surendran , Arnepalli Dali Naidu
Published: October 2019

Geomaterials involved in deep geological repositories, geosequestration of greenhouse gases, oil and gas exploration and so on are subjected to moderate temperatures in response to the natural geothermal gradient, as well as an imposed thermal flux. In such instances, the influence of temperature on the gas permeability characteristics of geomaterials needs to be evaluated in view of assessing their long-term performance. The present study describes a simplified gas permeability apparatus developed for evaluating the gas permeability characteristics of geomaterials over a range of compaction states and temperatures, based on the principle of pressure decay. Further, the study proposes a prediction model for estimating the gas permeability characteristics of a variety of geomaterials in terms of their soil–water characteristics, by considering the effect of temperature. The efficacy of the proposed model has been established by validating it using the experimental results of the present study, as well as those available in the literature.
Topology optimization of mechanical structures in stair-climbing assistive technology
Authors: Verma Abhishek , Singh Amandeep , Ramkumar Janakarajan
Published: October 2019

The design of ambient assistive technology, such as a wheelchair, is less explored from the engineering design perspective compared with other products of similar platforms, such as bicycles and small vehicles. A generic engineering design of mechanical products is explored using computational tools, such as finite-element analysis and integer programming software. Topology optimization of mechanical structures is a widely explored domain that exploits the union of both finite-element analysis and linear or non-linear convergence algorithms, such as Lagrangian multiplier. Analytical modeling of material properties, such as density, using ‘solid isotropic material with penalization’ helps a design engineer discretize the design domain and solve for the optimization of material properties, such as stiffness, loads and energy. This paper addresses solving a wheelchair-structure-optimization problem with compliance of low energy or minimum deflection of the structure. The wheelchair is designed according to loading patterns that occur in the Indian population using male and female anthropometric data. The wheelchair structures that are optimized in this paper are designed for normal-plane and slant-plane movements. The Lagrangian multiplier convergence algorithm is taken as the constraint function for material removal after obtaining an optimal criterion for multipoint load application and multiple degrees of freedom in the structure.
A Modified Peptide Derived from Goodpasture Autoantigen Arrested and Attenuated Kidney Injuries in a Rat Model of Anti-GBM Glomerulonephritis
Authors: Shi Yue , Jia Xiao-yu , Gu Qiu-hua , Wang Miao , Cui Zhao , Zhao Ming-hui
Published: October 2019

Significance Statement

The main target antigen of autoantibodies against glomerular basement membrane (GBM) in Goodpasture disease is the noncollagenous domain 1 of the α3 chain (α3NC1) of type IV collagen. The authors previously identified a nephritogenic peptide, P14 (α3127–148). In this study, they designed a modified peptide with one amino acid substitution in its core motif, replacing a pathogenic residue with a nonpathogenic one. Administering this modified peptide to rats with α3-P14–induced anti-GBM GN reduced inflammatory responses and crescent formation in the kidneys through inhibition of α3-P14 binding to antibodies and MHC II molecules, as well as through modulation of T cells, including inhibiting α3-P14–specific T cell proliferation and abating Th17 cell differentiation. This peptide modification approach may offer insights into treating Goodpasture disease and other autoimmune kidney disorders.

Background

In Goodpasture disease, the noncollagenous domain 1 of the α3 chain (α3NC1) of type IV collagen is the main target antigen of antibodies against glomerular basement membrane (GBM). We previously identified a nephritogenic epitope, P14 (α3127–148), that could induce crescentic nephritis in WKY rats, and defined its core motif. Designing a modified peptide, replacing critical pathogenic residues with nonpathogenic ones (on the basis of homologous regions in α1NC1 chain of type IV collagen, known to be nonpathogenic), might provide a therapeutic option for anti-GBM GN.

Methods

We synthesized a modified peptide, replacing a single amino acid, and injected it into α3-P14–immunized rats from day 0 (the early-treatment group) or a later-treatment group (from days 17 to 21). A scrambled peptide administrated with the same protocol served as a control.

Results

The modified peptide, but not the scrambled peptide, attenuated anti-GBM GN in both treatment groups, and halted further crescent formation even after disease onset. Kidneys from the modified peptide–treated rats exhibited reductions in IgG deposits, complement activation, and infiltration by T cells and macrophages. Treatment also resulted in an anti-inflammatory cytokine profile versus a proinflammatory profile for animals not receiving the modified peptide; it also reduced α3-P14–specific T cell activation, modulated T cell differentiation by decreasing Th17 cells and enhancing the ratio of Treg/Th17 cells, and inhibited binding of α3-P14 to antibodies and MHC II molecules.

Conclusions

A modified peptide involving alteration of a critical motif in a nephritogenic T cell epitope alleviated anti-GBM GN in a rat model. Our findings may provide insights into an immunotherapeutic approach for autoimmune kidney disorders such as Goodpasture disease.
Türkçe Eğitimi Açısından Celal Nuri İleri’nin “Yeni Alfabe ve İmla Dersleri” Adlı Eseri
Authors: PİLAV Salim , İNAÇ Sevinç
Published: October 2019

Bu araştırma ile Celal Nuri İleri’nin Yeni Alfabe
ve İmla Dersleri[1]
adlı eserinin ilk okuma ve yazma açısından durumunun tespit edilmesi, eserde
kullanılan öğretim ilke, yöntem ve tekniklerinin belirlenmesi ve dil bilgisi
öğretimi açısından durumunun tespit edilmesi amaçlanmıştır. Veriler doküman
incelemesi yöntemiyle toplanmıştır. Verilerin değerlendirilmesinde nitel analiz
tekniklerinden içerik analizi kullanılmıştır. Celal Nuri İleri’nin söz konusu eseri incelendiğinde Latin harflerini
tanıtmak ve öğretmek amacıyla kaleme alındığı, aynı zamanda Türkçe eğitimi
açısından önemli olan dört temel dil becerisinden okuma ve yazma becerilerine
ağırlık verildiği görülmüştür. Eser, Türkçe özel öğretim yöntemlerine göre
değerlendirildiğinde ise eserde bütünlük, hayatîlik, bilinenden bilinmeyene,
hedef kitleye görelik olmak üzere dört ilke; anlatma ve gösterip yaptırma olmak
üzere iki yöntem; soru-cevap, analiz-sentez, tamamlayıcı görev, özetleme,
tekrar çalışması, ilgi kurma, anlamlandırarak kodlayarak öğrenme olmak üzere
yedi teknik tespit edilmiştir. Eserin içerisinden bu ilke, yöntem ve tekniklere
uygun örnekler verilmiştir.
Akran Destekli Yazmanın İlkokul 4. Sınıf Öğrencilerinin Yazma Başarı ve Performansına Etkisi: Bir Pilot Araştırma
Authors: SARİKAYA İsmail , YILAR Ömer
Published: October 2019

Bu çalışmanın amacı akran destekli yazma
etkinliklerinin ilkokul 4. sınıf öğrencilerinin yazma başarı ve performansı
üzerindeki etkisini tespit edebilmektir. Çalışma, tek denekli desenlere uygun
olarak yürütülmüştür. Araştırmanın katılımcıları, küme rastgele örnekleme
yoluyla tespit edilmiş bir ilkokul 4. sınıf şubesinden seçilen altı öğrenciden
oluşmaktadır. Veri analizinde betimsel yöntemlerden faydalanılmış; akran
destekli yazma grubu ile sınıfın geri kalanına ait bulgular karşılaştırılmıştır.
Ayrıca akran destekli yazma grubunun ön-test ve son-test ölçüm sonuçları
Wilcoxon İşaretli Sıralar testi ile kıyaslanmıştır. Yapılan analizler sonucunda
sınıfın geri kalanına kıyasla akran destekli yazma grubunun yazma başarı
puanları, yazılan toplam kelime sayıları ve doğru kelime sayısı oran yüzdeleri
açısından daha avantajlı olduğu tespit edilmiştir. Akran destekli yazma
grubunun yazma başarı puanları ve doğru kelime sayısı oranlarında son-test
lehine anlamlı bir farklılığın olduğu da görülmüştür. Bu doğrultuda akran
destekli yazmanın ilkokul 4. sınıf öğrencilerinin yazma başarı ve performansına
olumlu yönde bir katkı sağladığı ifade edilebilir.