bluuebunny/crossref_metadata_2025 huggingface dataset:
Multi-Parametric Analysis Based on Physico-Chemical Characterization and Biochemical Methane Potential Estimation for the Selection of Industrial Wastes as Co-Substrates in Anaerobic Digestion
Authors: Ruiz Luz Marina , Fernández María , Genaro Ana , Martín-Pascual Jaime , Zamorano Montserrat
Published: July 2023

Anaerobic digestion is considered as one of the most feasible waste-to-energy technologies for the valorization of organic wastes. It can be applied to many different substrates but the mono-digestion of a single substrate usually has some important drawbacks due to the physico-chemical characteristics of the substrate. A feasible solution is the simultaneous co-digestion of several substrates with different composition and characteristics, so that synergetic effects may be generated and physico-chemical characteristics may be compensated, thus reaching higher process efficiencies and biogas production rates. In this work, a multi-parametric analysis for the objective comparison of industrial wastes was developed in order to help with decision making about their suitability as a co-substrate in anaerobic co-digestion. Criteria considered for this analysis included sample composition, C/N ratios, theoretical biochemical methane potential (BMP), and other important issues such as production rates, seasonality, and the distance to the WWTP or pre-treatment requirements. Results showed that, among the 13 evaluated wastes, 2 of them showed a higher potential for being used in anaerobic co-digestion: 1. Fried corn from the snack food industry and 2. Wet fatty pomace from the olive oil industry. Both wastes showed high estimated BMP values, high lipid and carbohydrate content, and C/N ratios in a proper range to improve the low C/N ratio of sewage sludge. Other wastes such as olive pomace (dry), skinless corn (not fried), and grape pomace from the winery industry may also be used as co-substrates. As a conclusion, this procedure based on a selection matrix can be considered as a useful tool to help both producers and WWTP operators to make decisions about the potential applicability of specific industrial wastes as co-substrates in anaerobic co-digestion.
Current Research on Green Ammonia (NH3) as a Potential Vector Energy for Power Storage and Engine Fuels: A Review
Authors: Estevez Rafael , López-Tenllado Francisco J. , Aguado-Deblas Laura , Bautista Felipa M. , Romero Antonio A. , Luna Diego
Published: July 2023

Considering the renewable electricity production using sustainable technologies, such as solar photovoltaics or wind turbines, it is essential to have systems that allow for storing the energy produced during the periods of lower consumption as well as the energy transportation through the distribution network. Despite hydrogen being considered a good candidate, it presents several problems related to its extremely low density, which requires the use of very high pressures to store it. In addition, its energy density in volumetric terms is still clearly lower than that of most liquid fuels. These facts have led to the consideration of ammonia as an alternative compound for energy storage or as a carrier. In this sense, this review deals with the evaluation of using green ammonia for different energetic purposes, such as an energy carrier vector, an electricity generator and E-fuel. In addition, this study has addressed the latest studies that propose the use of nitrogen-derived compounds, i.e., urea, hydrazine, ammonium nitrate, etc., as alternative fuels. In this study, the possibility of using other nitrogen-derived compounds, i.e., an update of the ecosystem surrounding green ammonia, has been assessed, from production to consumption, including storage, transportation, etc. Additionally, the future challenges in achieving a technical and economically viable energy transition have been determined.
From Buildings to Communities: Exploring the Role of Financial Schemes for Sustainable Plus Energy Neighborhoods
Authors: Kerstens Andrea , Greco Angela
Published: July 2023

The realization of sustainable plus energy neighborhoods (SPENs) is key to achieving a carbon neutral built environment, and meeting the objectives of the green deal. Financial schemes have demonstrated effectiveness in driving the energy transition of individual buildings. However, the role of financial schemes in initiating the development of SPENs remains unclear. This study aims to address this research gap by investigating the extent to which existing financial schemes support the technological advancements and stakeholders involved in SPEN realization. The focus is on four European countries: Austria, The Netherlands, Norway, and Spain, where noteworthy SPEN initiatives have been established. This study investigates whether and how financial schemes facilitate SPEN development and address the neighborhood-level dynamics. Our research used a mixed-methods approach comprising a literature review, case studies, and interviews. Our findings shed light on two significant barriers within current schemes. Firstly, the schemes rarely incentivize collective energy sharing and may inadvertently impede individuals’ prosumerism. Secondly, they primarily favor individuals capable of making upfront capital investments, rendering them inaccessible to a large portion of European citizens. By identifying these limitations, our study highlights the need for policy adjustments and innovative financial mechanisms to overcome the barriers hindering SPEN implementation. Moreover, our research contributes to the broader understanding of sustainable urban development and offers insights that extend beyond the examined countries, aiding policymakers and stakeholders in other regions facing similar challenges.
Development of Virtual Inertia Control with State-of-Charge Recovery Strategy Using Coordinated Secondary Frequency Control for Optimized Battery Capacity in Isolated Low Inertia Grid
Authors: Jufri Fauzan Hanif , Jung Jaesung , Sudiarto Budi , Garniwa Iwa
Published: July 2023

Integrating renewable energy through inverter-based generators has decreased the power system’s inertia. Reduced inertia may lead to frequency instability during power imbalance disturbances, particularly in an isolated power system with limited inertia. The Battery Energy Storage System (BESS) and a virtual inertia (VI) emulation control system have become popular to mitigate this issue. Nonetheless, the BESS utilization for VI emulation is highly dependent on the availability of BESS capacity, which may affect the energy cost. Therefore, developing a VI emulation control strategy that requires less energy and can recover the state of charge (SoC) to a desired level to optimize BESS utilization is required. This paper proposes a VI control with an SoC recovery strategy through coordination with the generators’ secondary frequency control. Instead of relying on the frequency, such as in the conventional approach, the controlled signal of the generators’ secondary frequency control also includes the VI power and BESS SoC. Hence, the generators can contribute to lowering the VI required energy and recovering the BESS SoC. The results show that the proposed method outperforms the conventional method by requiring around 36% lower energy and the ability to maintain the BESS SoC.
Seismic Resilience and Design Factors of Inline Seismic Friction Dampers (ISFDs)
Authors: Naghshineh Ali , Bagchi Ashutosh , Tehrani Fariborz M.
Published: July 2023

While damping devices can provide supplemental damping to mitigate building vibration due to wind or earthquake effects, integrating them into the design is more complex. For example, the Canadian code does not provide building designs with inline friction dampers. The objective of this present article was to study the overstrength, ductility, and response modification factors of concrete frame buildings with inline friction dampers in the Canadian context. For that purpose, a set of four-, eight-, and fourteen-story ductile concrete frames with inline seismic friction dampers, designed based on the 2015 National Building Code of Canada (NBCC), was considered. The analyses included pushover analysis in determining seismic characteristics and dynamic response history analysis using twenty-five ground motion records to assess the seismic performance of the buildings equipped with inline seismic friction dampers. The methodology considered diagonal braces, including different 6 m and 8 m span lengths. The discussion covers the prescribed design values for overstrength, ductility, and response modification factors, as well as the performance assessment of the buildings. The results revealed that increasing the height of the structure and reducing the span length increases the response modification factors.
Mechanical Design and Numerical Analysis of a New Front Wing for a Formula One Vehicle
Authors: Laguna-Canales Aldo Saul , Urriolagoitia-Sosa Guillermo , Romero-Ángeles Beatriz , Martinez-Mondragon Miguel , García-Laguna Miguel Angel , Correa-Corona Martin Ivan , Maya-Anaya Daniel , Urriolagoitia-Calderón Guillermo Manuel
Published: July 2023

In motorsports, the correct design of every device that constitutes a vehicle is a significant task for engineers because the car’s efficiency on the track depends on making it competitive. However, the physical integrity of the pilot is also at stake, since a bad vehicle design can cause serious mishaps. To achieve the correct development of a front wing for a single-seater vehicle, it is necessary to adequately simulate the forces that are generated on a car to evaluate its performance, which depends on the aerodynamic forces of the front wing that are present due to its geometry. This work provided a new design and evaluation through the numerical analysis of three new front wings for single-seater vehicles that comply with the regulations issued by the International Automobile Federation (FIA) for the 2022 season. Additionally, a 3D-printed front wing prototype was developed to be evaluated in an experimental study to corroborate the results obtained through computer simulations. A wind tunnel experiment test was performed to validate the numerically simulated data. Also, we developed a numerical simulation and characterization of three front wings already used in Formula One from a previous season (the end of the 2021 season). This work defined how these devices perform, and in the same way, it identified how their evolution over time has provided them with substantial benefits and greater efficiency. All the numerical simulations were carried out by applying the Finite Volume Method, allowing us to obtain the values of the aerodynamic forces that act on the front wing. Also, it was possible to establish a comparison between the three newly designed proposals from the most aerodynamic advantages to produce a prototype and perform an experimental test. The results of the experimental test showed similarity to those of the numerical analyses, making it clear that the methodology followed during the development of the work was correct. In addition, the mechanical designs carried out to develop the front wing can be considered ideal, because the results showed that the front wing could be competitive, and applying it caused a downforce to be favored that prevented the car from being thrown off the track. Additionally, the results indicate this is an effective proposal for use in a single-seater vehicle and that the design methodology delivers optimal results.
Stress and Coping Strategies of Online Nursing Practicum Courses for Taiwanese Nursing Students during the COVID-19 Pandemic: A Qualitative Study
Authors: Huang Hui-Man , Fang Yu-Wen
Published: July 2023

Background: The coronavirus disease (COVID-19) pandemic has resulted in significant changes in nursing education. Maintaining social distance could slow down the spread of COVID-19, and it was necessary, but it significantly reduced students’ hands-on clinical practice experience in healthcare settings. Traditional classroom teaching in schools has transitioned to distance or online learning methods, which significantly reduced students’ hands-on clinical practice experience in healthcare settings. Although distance education had been implemented for a long time, there are many problems and challenges to be resolved. The experiences and needs of nursing students in remote clinical training urgently require further understanding. Purpose: To understand the stress and coping strategies of online nursing practicum courses for Taiwanese nursing students during the COVID-19 pandemic. Methods: A qualitative research approach with purposive sampling was supplemented by snowball sampling. Semi-structured interviews were conducted, and the data were collected following the eight-step process outlined by Waltz, Strickland, and Lenz (2010). The participants were 12 nursing students on a two-year nursing RN-to-BSN program at a university in Eastern Taiwan, consisting of 11 females and 1 male student. Findings: The stress and coping behaviors of nursing students consist of four main themes, each with three subthemes, including “urgent changes”, “the gaps between online courses and practical operations”, “mixed feelings of joy and anxiety” and “unexpected gains”. Conclusions: The pandemic has impacted nursing students’ learning and living. Engaging in online nursing practicum brought about significant stress; nevertheless, students employed various coping strategies to navigate through this challenging period. The findings of this study would also help nursing educators understand the learning gaps in clinical practicum among students.
Areas of Research Focus and Trends in the Research on the Application of VR in Rehabilitation Medicine
Authors: Wang Chen , Kong Jingqi , Qi Huiying
Published: July 2023

Objective: To establish the areas of research focus in the application of VR in rehabilitation medicine, analyze its themes and trends, and offer a reference for future related research in this field. Methods: This paper provides an in-depth analysis of the development process, areas of research focus, and research trends in the field of the application of VR in rehabilitation medicine, using the Web of Science core dataset as the source and using a bibliometric analysis with CiteSpace. Results: The application of VR in rehabilitation medicine was composed of three stages, and the research topics were reviewed from five perspectives: neurological rehabilitation, psychological treatment, pain distraction, cardiopulmonary rehabilitation, and visual–spatial disorder. Limitations: The research data were sourced from the Web of Science core dataset only, and the data-sample size was not comprehensive. Conclusions: Overcoming VR-technology-induced vertigo, mental disorders from the overuse of VR, individualized treatments, and integration with traditional therapy are all challenges in the application of VR in rehabilitation medicine that require research. In addition, developing VR products with better experiences, constructing standardized guidelines, and conducting more high-quality clinical studies are all future research topics related to the application of VR in rehabilitation medicine.
Changing Natures: On Theory and Practice of Breeding in the European Middle Ages
Authors: Schneiter Camille
Published: July 2023

While throughout modern history it has been shown how thoroughly biological discourses were shaped by conceptions originating in the theory and praxis of breeding, for the medieval period similar studies are mostly absent. This paper offers a symmetrical history of theory and praxis of breeding by asking to what extent they shaped medieval conceptions of human ‘race’ and ‘ancestry’ in Europe. For scholarly knowledge of breeding, the analysis relies on Albertus Magnus’ extensive Aristotelian work De animalibus. For the practical knowledge of the breeders, scattered indications from the secondary literature are compiled and promising primary sources are outlined for further research. The paper finds that various concepts and practices whose origins are commonly placed in the early modern period were already present in the Middle Ages, including the concept of reproductive heredity and the view that creation diversified over time through reproductive ancestry. Breeding practices, thus, existed before the rise of genetics in modern biology. The medieval conceptions of ‘race’ and ‘ancestry’ underwent conceptual transfers from the non-human into the human sphere, collapsing the qualitative distinction of the two spheres into one quantitively graded overarching image of nature.
Ecology of Aquatic Invertebrates in Springs and Headwater Streams: Imperiled Habitats in a Changing World
Authors: Bowles David E. , Nowlin Weston H.
Published: July 2023

Headwater streams and springs and their resident biotas are vulnerable to a broad range of anthropogenic stressors [...]
Toxic Effects of Two Redox States of Thallium on Immortalised Hypothalamic GT1-7 Neuronal Cells
Authors: Mizuno Dai , Kawahara Masahiro , Konoha-Mizuno Keiko , Ogawara Terumasa , Hama Ryoji , Yamazaki Kentaro
Published: July 2023

Thallium (Tl), is a highly toxic heavy metal that exists in monovalent (Tl(I)) and trivalent (Tl(III)) ionic states. This study aimed to compare the toxicities of Tl(I) and Tl(III) in a mouse hypothalamic GT1-7 neuronal cell line. Decreased viability and increased cytotoxicity were observed in the GT1-7 cells 16 h after Tl(I) or Tl(III) treatment. Tl(III) was more cytotoxic, than Tl(I), as indicated by extracellular lactate dehydrogenase levels. Both treatments induced caspase 3 activity, DNA fragmentation, malondialdehyde (MDA) production, and superoxide dismutase activity in the cells. MDA production was higher after Tl(III) than after Tl(I) treatment. Moreover, co-treatment with antioxidants, such as mannitol, ascorbic acid, or tocopherol, significantly attenuated the Tl-induced decrease in GT1-7 cell numbers. Therefore, both treatments induced oxidative stress-related apoptosis. Furthermore, Tl(III) reduced the cell viability more subtly than Tl(I) after 1 and 3 h of treatment. This effect was enhanced by co-treatment with maltol or citric acid, which promoted the influx of metallic elements into the cells. Thus, Tl(III) entered GT1-7 cells later than Tl(I) and had a delayed onset of toxicity. However, Tl(III) likely produces more extracellular lipid peroxides, which may explain its stronger cytotoxicity.
High CD142 Level Marks Tumor-Promoting Fibroblasts with Targeting Potential in Colorectal Cancer
Authors: Soós András Áron , Kelemen Andrea , Orosz Adrián , Szvicsek Zsuzsanna , Tölgyes Tamás , Dede Kristóf , Bursics Attila , Wiener Zoltán
Published: July 2023

Colorectal cancer (CRC) has a high incidence and is one of the leading causes of cancer-related death. The accumulation of cancer-associated fibroblasts (CAF) induces an aggressive, stem-like phenotype in tumor cells, and it indicates a poor prognosis. However, cellular heterogeneity among CAFs and the targeting of both stromal and CRC cells are not yet well resolved. Here, we identified CD142high fibroblasts with a higher stimulating effect on CRC cell proliferation via secreting more hepatocyte growth factor (HGF) compared to CD142low CAFs. We also found that combinations of inhibitors that had either a promising effect in other cancer types or are more active in CRC compared to normal colonic epithelium acted synergistically in CRC cells. Importantly, heat shock protein 90 (HSP90) inhibitor selected against CD142high fibroblasts, and both CRC cells and CAFs were sensitive to a BCL-xL inhibitor. However, targeting mitogen-activated protein kinase kinase (MEK) was ineffective in fibroblasts, and an epigenetic inhibitor selected for a tumor cell population with markers of aggressive behavior. Thus, we suggest BCL-xL and HSP90 inhibitors to eliminate cancer cells and decrease the tumor-promoting CD142high CAF population. This may be the basis of a strategy to target both CRC cells and stromal fibroblasts, resulting in the inhibition of tumor relapse.
Berberine Reduces Lipid Accumulation in Obesity via Mediating Transcriptional Function of PPARδ
Authors: Shou Jia-Wen , Shaw Pang-Chui
Published: July 2023

Obesity is defined as a dampness-heat syndrome in traditional Chinese medicine. Coptidis Rhizoma is an herb used to clear heat and eliminate dampness in obesity and its complications. Berberine (BBR), the main active compound in Coptidis Rhizoma, shows anti-obesity effects. Peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that regulate the expression of genes involved in energy metabolism, lipid metabolism, inflammation, and adipogenesis. However, whether PPARs are involved in the anti-obesity effect of BBR remains unclear. As such, the aim of this study was to elucidate the role of PPARs in BBR treatment on obesity and the underlying molecular mechanisms. Our data showed that BBR produced a dose-dependent regulation of the levels of PPARγ and PPARδ but not PPARα. The results of gene silencing and specific antagonist treatment demonstrated that PPARδ is key to the effect of BBR. In 3T3L1 preadipocytes, BBR reduced lipid accumulation; in high-fat-diet (HFD)-induced obese mice, BBR reduced weight gain and white adipose tissue mass and corrected the disturbed biochemical parameters, including lipid levels and inflammatory and oxidative markers. Both the in vitro and in vivo efficacies of BBR were reversed by the presence of a specific antagonist of PPARδ. The results of a mechanistic study revealed that BBR could activate PPARδ in both 3T3L1 cells and HFD mice, as evidenced by the significant upregulation of PPARδ endogenous downstream genes. After activating by BBR, the transcriptional functions of PPARδ were invoked, exhibiting negative regulation of CCAAT/enhancer-binding protein α (Cebpα) and Pparγ promoters and positive mediation of heme oxygenase-1 (Ho-1) promoter. In summary, this is the first report of a novel anti-obesity mechanism of BBR, which was achieved through the PPARδ-dependent reduction in lipid accumulation.
Evaluation of the Predatory Mite Neoseiulus barkeri against Spider Mites Damaging Rubber Trees
Authors: Chen Junyu , Zheng Lijiu , Ye Zhengpei , Wang Jianyun , Zhang Fangping , Fu Yueguan , Zhang Chenghui
Published: July 2023

The spider mites Eotetranychus sexmaculatus, Eutetranychus orientalis and Oligonychus biharensisin are severe pests of rubber trees in China. The predatory mite Neoseiulus barkeri has been found to be a natural enemy of these three pests, while nothing is known about the biological performance of this phytoseiid predator against these phytophagous mites. In this study, the development, survivorship, reproduction, adult longevity, fecundity, sex ratio and population growth parameters of N. barkeri fed on these pests were evaluated in comparison to the factitious prey Tyrophagus putrescentiae in the laboratory at 25 ± 1 °C, 75 ± 5% relative humidity and a 12:12 (L:D) h photoperiod. The results showed that N. barkeri could develop from egg to adult and reproduced successfully on the three preys. The survival rate of N. barkeri from egg to adult was higher when fed on E. orientalis (100%) and T. putrescentiae (100%) than when fed on O. biharensisin (93.60%) and E. sexmaculatus (71.42%). The shortest and longest generation time for N. barkeri were observed on E. orientalis with 6.67 d and E. sexmaculatus with 12.50 d, respectively. The maximum fecundity (29.35 eggs per female) and highest intrinsic rate of increase (rm = 0.226) were recorded when N. barkeri fed on E. orientalis, while feeding on E. sexmaculatus gave the minimum fecundity (1.87 eggs per female) and lowest reproduction rate (rm = 0.041). The values of these parameters for N. barkeri evaluated on O. biharensisin were found to be comparable to those obtained on T. putrescentiae. The sex ratio of N. barkeri progeny on the preys mentioned above, apart from O. biharensisin, was female biased. According to the findings, N. barkeri could serve as a promising biocontrol agent against E. orientalis and O. biharensisin, and possibly E. sexmaculatus on rubber trees.
Brain–Computer-Interface-Based Smart-Home Interface by Leveraging Motor Imagery Signals
Authors: Cariello Simona , Sanalitro Dario , Micali Alessandro , Buscarino Arturo , Bucolo Maide
Published: July 2023

In this work, we propose a brain–computer-interface (BCI)-based smart-home interface which leverages motor imagery (MI) signals to operate home devices in real-time. The idea behind MI-BCI is that different types of MI activities will activate various brain regions. Therefore, after recording the user’s electroencephalogram (EEG) data, two approaches, i.e., Regularized Common Spatial Pattern (RCSP) and Linear Discriminant Analysis (LDA), analyze these data to classify users’ imagined tasks. In such a way, the user can perform the intended action. In the proposed framework, EEG signals were recorded by using the EMOTIV helmet and OpenVibe, a free and open-source platform that has been utilized for EEG signal feature extraction and classification. After being classified, such signals are then converted into control commands, and the open communication protocol for building automation KNX (“Konnex”) is proposed for the tasks’ execution, i.e., the regulation of two switching devices. The experimental results from the training and testing stages provide evidence of the effectiveness of the users’ intentions classification, which has subsequently been used to operate the proposed home automation system, allowing users to operate two light bulbs.
Psychiatric Treatment in Pregnancy: A Narrative Review
Authors: Gruszczyńska-Sińczak Iga , Wachowska Katarzyna , Bliźniewska-Kowalska Katarzyna , Gałecki Piotr
Published: July 2023

Pregnancy, childbirth and the puerperium are a series of transformations and huge changes in a woman’s life, which may also be accompanied by various mental problems. Very often, women experiencing mental disorders during this period and their doctors face a decision on safety of treatment. The purpose of the following review was to assess the safety of treatment during pregnancy. Internet scientific database PubMed was searched. There are groups of psychiatric medications contraindicated during pregnancy such as valproates as well as relatively safe ones such as selective serotonin reuptake inhibitors (SSRIs) or antipsychotics. However, in every clinical situation, a decision should be made with caution, based on individual characteristics of patient, severity of disorder and clinical picture.
The Association between Emergency Department Length of Stay and In-Hospital Mortality in Older Patients Using Machine Learning: An Observational Cohort Study
Authors: Wu Lijuan , Chen Xuanhui , Khalemsky Anna , Li Deyang , Zoubeidi Taoufik , Lauque Dominique , Alsabri Mohammed , Boudi Zoubir , Kumar Vijaya Arun , Paxton James , Tsilimingras Dionyssios , Kurland Lisa , Schwartz David , Hachimi-Idrissi Said , Camargo Carlos A. , Liu Shan W. , Savioli Gabriele , Intas Geroge , Soni Kapil Dev , Junhasavasdikul Detajin , Cabello Jose Javier Trujillano , Rathlev Niels K. , Tazarourte Karim , Slagman Anna , Christ Michael , Singer Adam J. , Lang Eddy , Ricevuti Giovanni , Li Xin , Liang Huiying , Grossman Shamai A. , Bellou Abdelouahab
Published: July 2023

The association between emergency department (ED) length of stay (EDLOS) with in-hospital mortality (IHM) in older patients remains unclear. This retrospective study aims to delineate the relationship between EDLOS and IHM in elderly patients. From the ED patients (n = 383,586) who visited an urban academic tertiary care medical center from January 2010 to December 2016, 78,478 older patients (age ≥60 years) were identified and stratified into three age subgroups: 60–74 (early elderly), 75–89 (late elderly), and ≥90 years (longevous elderly). We applied multiple machine learning approaches to identify the risk correlation trends between EDLOS and IHM, as well as boarding time (BT) and IHM. The incidence of IHM increased with age: 60–74 (2.7%), 75–89 (4.5%), and ≥90 years (6.3%). The best area under the receiver operating characteristic curve was obtained by Light Gradient Boosting Machine model for age groups 60–74, 75–89, and ≥90 years, which were 0.892 (95% CI, 0.870–0.916), 0.886 (95% CI, 0.861–0.911), and 0.838 (95% CI, 0.782–0.887), respectively. Our study showed that EDLOS and BT were statistically correlated with IHM (p < 0.001), and a significantly higher risk of IHM was found in low EDLOS and high BT. The flagged rate of quality assurance issues was higher in lower EDLOS ≤1 h (9.96%) vs. higher EDLOS 7 h <t≤ 8 h (1.84%). Special attention should be given to patients admitted after a short stay in the ED and a long BT, and new concepts of ED care processes including specific areas and teams dedicated to older patients care could be proposed to policymakers.
Possible Advantages of Minimal-Invasive Approaches in Rectal Cancer Surgery: A Nationwide Analysis
Authors: Horvath Philipp , Steidle Christoph , Yurttas Can , Baur Isabella , Königsrainer Alfred , Königsrainer Ingmar
Published: July 2023

(1) Background: Laparoscopic resection for colon and rectal cancer was introduced in the early 1990s; the aim of this analysis was to show possible advantages of minimal-invasive approaches in rectal cancer surgery. (2) Methods: From 2016 to 2020, all patients undergoing open, laparoscopic or robotic-assisted rectal cancer surgery in Germany were retrospectively analyzed regarding sex distribution, conversion rates and in-hospital mortality rates according to nationwide hospital billing data based on diagnosis-related groups (DRGs). (3) Results: In total, 68,112 patients were analyzed, and most commonly, low anterior rectal resections with primary anastomosis (n = 25,824) were performed with an increase of minimal-invasive procedures over the years (open: 51% to 27%; laparoscopic: 47% to 63% and robotic: 2% to 10%). In-hospital mortality rate was 2.95% (n = 2012). In total, 4.61%, 1.77%, 1.14% and 3.95% of patients with open, laparoscopic, robotic and converted-to-open surgery died during hospital stay, respectively (open vs. laparoscopic p < 0.0001; open vs. robotic p < 0.00001; laparoscopic vs. robotic p = 0.001). Conversion rates were significantly more favorable in the robotic compared to the laparoscopic group. (11.94% vs. 2.53%; p < 0.0001). (4) Conclusion: Minimal-invasive rectal cancer surgery might have some advantages in terms of a reduced in-hospital mortality, and an improved conversion rate for the robotic approach.
An Improved A-Star Ship Path-Planning Algorithm Considering Current, Water Depth, and Traffic Separation Rules
Authors: Zhen Rong , Gu Qiyong , Shi Ziqiang , Suo Yongfeng
Published: July 2023

The influence of the maritime environment such as water currents, water depth, and traffic separation rules should be considered when conducting ship path planning. Additionally, the maneuverability constraints of the ship play a crucial role in navigation. Addressing the limitations of the traditional A-star algorithm in ship path planning, this paper proposes an improved A-star algorithm. Specifically, this paper examines the factors influencing ship navigation safety, and develops a risk model that takes into account water currents, water depth, and obstacles. The goal is to mitigate the total risk of ship collisions and grounding. Secondly, a traffic model is designed to ensure that the planned path adheres to the traffic separation rules and reduces the risk of collision with incoming ships. Then, a turning model and smoothing method are designed to make the generated path easy to track and control for the ship. To validate the effectiveness of the proposed A-star ship path-planning algorithm, three cases are studied in simulations and representative operational scenarios. The results of the cases demonstrate that the proposed A-star ship path-planning algorithm can better control the distance to obstacles, effectively avoid shallow water areas, and comply with traffic separation rules. The safety level of the path is effectively improved.
Risk Communication about COVID-19 in India: Corpus-Assisted Discourse Analysis of Mainstream News Reports about India’s Wave I and Wave II Outbreaks
Authors: Ding Huiling , Pandya Manushri
Published: July 2023

This study employed critical rhetorical analysis and corpus-assisted discourse analysis in analyzing the news coverage of India’s transition from Wave I to Wave II Focusing on news coverage from the Times of India, we examined how COVID-19 was constructed in the public and technical spheres and how India’s COVID-19 risk communication was shaped by unique geopolitical, cultural, infrastructural, and material factors. Our analysis highlights the tendency to datify COVID as statistics and case numbers, which both dehumanizes the patients and caretakers while erasing human suffering. It also reveals the critical roles played by the geopolitical, socioeconomic, infrastructural, and material conditions in shaping the national and regional capacities to respond to such far-reaching crises. Last but not least, affect and trust play prominent roles in the public coping with emerging pandemics given the uncertainties on all fronts, and thus should be centrally highlighted and addressed in public policies.
Characteristics and Projection of Rainfall Erosivity Distribution in the Hengduan Mountains
Authors: Liang Xinlan , Zhang Lei , He Shuqin , Song Ke , Zheng Zicheng
Published: July 2023

This study examines the spatiotemporal variations of rainfall erosivity in the Hengduan Mountains, known for their rugged terrain and high potential for soil erosion risks, over the past 30 years. Additionally, it investigates the changing trends of rainfall erosivity between 2025 and 2040 under the Sustainable Development Pathway 2–4.5 (SSP2–4.5), using four Global Climate Models (GCMs) based on the Coupled Model Intercomparison Project phase 6 (CMIP6). The results indicate: (1) The annual distribution of rainfall erosivity in the Hengduan Mountains exhibited significant seasonal variations, ranking in the order of summer > autumn > spring > winter on a seasonal scale. (2) Over the past 30 years, there has been a slight decrease in annual precipitation and a corresponding slight increase in rainfall erosivity. Periodic extreme values occur every 6–8 years. (3) Spatially, rainfall erosivity demonstrates a decreasing gradient from southeast to northwest. There is a significant positive correlation between rainfall erosivity and precipitation, while a significant negative correlation exists with elevation in the vertical direction. Furthermore, the northeastern part of the Hengduan Mountains exhibits an increasing trend of rainfall erosivity, while the southern region experiences a decreasing trend. (4) Considering the joint driving forces of increased precipitation and erosive rainfall events, rainfall erosivity is expected to significantly increase in the future, posing a more severe risk of soil erosion in this region.
The Heterogeneity of the Drivers of Urban Form in China: Perspectives from Regional Disparities and Development Stage Variations
Authors: Wu Rong , Zhang Yongli , Dai Meilin , Li Qingyin , Sun Changlong
Published: July 2023

Although there have been many discussions about the influencing factors of urban expansion, the heterogeneity of the driving mechanisms behind urban form remains poorly understood. Therefore, this paper evaluated the heterogeneous impacts of potential determinants on urban form, considering regional disparities and the stage of development. Based on land use data collected from Landsat ETM and TM scenes, the landscape metrics of urban size, urban centrality, urban shape irregularity, and urban fragmentation were measured to describe the urban form of 265 Chinese cities. We find that the regional disparities and development-stage variations significantly affect urban form. All urban form variables showed a significant stair-stepping difference in cities at various development stages, indicating that as a city upgrades its level of development, the intensity of urban expansion gradually increases, the shape of the urban edge becomes more fragmented and the urban built-up area becomes more compact. Urban form in Chinese cities shows significant geographical heterogeneity in terms of its driving forces. The effect of the socioeconomic factors on urban form also presented changes depending on the development stage. Our results provide helpful references for policymakers within urban spatial structure planning and land resource management.
Dual Antiplatelet Therapy: A Concise Review for Clinicians
Authors: Virk Hafeez Ul Hassan , Escobar Johao , Rodriguez Mario , Bates Eric R. , Khalid Umair , Jneid Hani , Birnbaum Yochai , Levine Glenn N. , Smith Sidney C. , Krittanawong Chayakrit
Published: July 2023

Dual antiplatelet therapy (DAPT) combines two antiplatelet agents to decrease the risk of thrombotic complications associated with atherosclerotic cardiovascular diseases. Emerging data about the duration of DAPT is being published continuously. New approaches are trying to balance the time, benefits, and risks for patients taking DAPT for established cardiovascular diseases. Short-term dual DAPT of 3–6 months, or even 1 month in high-bleeding risk patients, is equivalent in terms of efficacy and effectiveness compared to long-term DAPT for patients who experienced percutaneous coronary intervention in an acute coronary syndrome setting. Prolonged DAPT beyond 12 months reduces stent thrombosis, major adverse cardiovascular events, and myocardial infarction rates but increases bleeding risk. Extended DAPT does not significantly benefit stable coronary artery disease patients in reducing stroke, myocardial infarction, or cardiovascular death. Ticagrelor and aspirin reduce cardiovascular events in stable coronary artery disease with diabetes but carry a higher bleeding risk. Antiplatelet therapy duration in atrial fibrillation patients after percutaneous coronary intervention depends on individual characteristics and bleeding risk. Antiplatelet therapy is crucial for post-coronary artery bypass graft and transcatheter aortic valve implantation; Aspirin (ASA) monotherapy is preferred. Antiplatelet therapy duration in peripheral artery disease depends on the scenario. Adding vorapaxar and cilostazol may benefit secondary prevention and claudication, respectively. Carotid artery disease patients with transient ischemic attack or stroke benefit from antiplatelet therapy and combining ASA and clopidogrel is more effective than ASA alone. The optimal duration of DAPT after carotid artery stenting is uncertain. Resistance to ASA and clopidogrel poses an incremental risk of deleterious cardiovascular events and stroke. The selection and duration of antiplatelet therapy in patients with cardiovascular disease requires careful consideration of both efficacy and safety outcomes. The use of combination therapies may provide added benefits but should be weighed against the risk of bleeding. Further research and clinical trials are needed to optimize antiplatelet treatment in different patient populations and clinical scenarios.
Methyl-4-hydroxy-2-(2-hydroxypropan-2-yl)-6-methyl-2,3-dihydrobenzofuran-5-carboxylate
Authors: Astakala Rishi Vachaspathy , Preet Gagan , Ebel Rainer , Jaspars Marcel
Published: July 2023

Microorganisms are an important source of compounds that are pharmaceutically active, both as leads and as scaffolds for synthesis. Often, interesting chemistry is uncovered by exploring new biomes, of which the Chilean Atacama Desert is a prime example. This paper describes the isolation and structural characterisation, using HR-LCMS and 1D and 2D NMR, of a new compound belonging to a family of compounds called radstrictins. The compound was isolated from a fungus, that had itself been isolated from a soil sample from the Atacama Desert. The compound was tested against pathogenic strains associated with bovine mastitis, but was found to be devoid of antimicrobial activity.
A Probabilistic Transformation of Distance-Based Outliers
Authors: Muhr David , Affenzeller Michael , Küng Josef
Published: July 2023

The scores of distance-based outlier detection methods are difficult to interpret, and it is challenging to determine a suitable cut-off threshold between normal and outlier data points without additional context. We describe a generic transformation of distance-based outlier scores into interpretable, probabilistic estimates. The transformation is ranking-stable and increases the contrast between normal and outlier data points. Determining distance relationships between data points is necessary to identify the nearest-neighbor relationships in the data, yet most of the computed distances are typically discarded. We show that the distances to other data points can be used to model distance probability distributions and, subsequently, use the distributions to turn distance-based outlier scores into outlier probabilities. Over a variety of tabular and image benchmark datasets, we show that the probabilistic transformation does not impact outlier ranking (ROC AUC) or detection performance (AP, F1), and increases the contrast between normal and outlier score distributions (statistical distance). The experimental findings indicate that it is possible to transform distance-based outlier scores into interpretable probabilities with increased contrast between normal and outlier samples. Our work generalizes to a wide range of distance-based outlier detection methods, and, because existing distance computations are used, it adds no significant computational overhead.
Dynamics of Non-Autonomous Stochastic Semi-Linear Degenerate Parabolic Equations with Nonlinear Noise
Authors: Liu Xin , Li Yanjiao
Published: July 2023

In the present paper, we aim to study the long-time behavior of a stochastic semi-linear degenerate parabolic equation on a bounded or unbounded domain and driven by a nonlinear noise. Since the theory of pathwise random dynamical systems cannot be applied directly to the equation with nonlinear noise, we first establish the existence of weak pullback mean random attractors for the equation by applying the theory of mean-square random dynamical systems; then, we prove the existence of (pathwise) pullback random attractors for the Wong–Zakai approximate system of the equation. In addition, we establish the upper semicontinuity of pullback random attractors for the Wong–Zakai approximate system of the equation under consideration driven by a linear multiplicative noise.
Effects of RIPC on the Metabolomical Profile during Lower Limb Digital Subtraction Angiography: A Randomized Controlled Trial
Authors: Kuusik Karl , Kasepalu Teele , Zilmer Mihkel , Eha Jaan , Paapstel Kaido , Kilk Kalle , Rehema Aune , Kals Jaak
Published: July 2023

Remote ischemic preconditioning (RIPC) has demonstrated protective effects in patients with lower extremity arterial disease (LEAD) undergoing digital subtraction angiography (DSA) and/or percutaneous transluminal angioplasty (PTA). This study aimed to investigate the impact of RIPC on the metabolomical profile of LEAD patients undergoing these procedures and to elucidate its potential underlying mechanisms. A total of 100 LEAD patients were enrolled and randomly assigned to either the RIPC group (n = 46) or the sham group (n = 54). Blood samples were drawn before and 24 h after intervention. Targeted metabolomics analysis was performed using the AbsoluteIDQ p180 Kit, and changes in metabolite concentrations were compared between the groups. The RIPC group demonstrated significantly different dynamics in nine metabolites compared to the sham group, which generally showed a decrease in metabolite concentrations. The impacted metabolites included glutamate, taurine, the arginine-dimethyl-amide-to-arginine ratio, lysoPC a C24:0, lysoPC a C28:0, lysoPC a C26:1, PC aa C38:1, PC ae C30:2, and PC ae C44:3. RIPC exhibited a ‘stabilization’ effect, maintaining metabolite levels amidst ischemia-reperfusion injuries, suggesting its role in enhancing metabolic control. This may improve outcomes for LEAD patients. However, additional studies are needed to definitively establish causal relationships among these metabolic changes.
Periodontal Pathogens and Their Links to Neuroinflammation and Neurodegeneration
Authors: Visentin David , Gobin Ivana , Maglica Željka
Published: July 2023

Pathogens that play a role in the development and progression of periodontitis have gained significant attention due to their implications in the onset of various systemic diseases. Periodontitis is characterized as an inflammatory disease of the gingival tissue that is mainly caused by bacterial pathogens. Among them, Porphyromonas gingivalis, Treponema denticola, Fusobacterium nucleatum, Aggregatibacter actinomycetemcomitans, and Tannerella forsythia are regarded as the main periodontal pathogens. These pathogens elicit the release of cytokines, which in combination with their virulence factors induce chronic systemic inflammation and subsequently impact neural function while also altering the permeability of the blood–brain barrier. The primary objective of this review is to summarize the existing information regarding periodontal pathogens, their virulence factors, and their potential association with neuroinflammation and neurodegenerative diseases. We systematically reviewed longitudinal studies that investigated the association between periodontal disease and the onset of neurodegenerative disorders. Out of the 24 studies examined, 20 showed some degree of positive correlation between periodontal disease and neurodegenerative disorders, with studies focusing on cognitive function demonstrating the most robust effects. Therefore, periodontal pathogens might represent an exciting new approach to develop novel preventive treatments for neurodegenerative diseases.
Codon Usage Bias Analysis in Macronuclear Genomes of Ciliated Protozoa
Authors: Fu Yu , Liang Fasheng , Li Congjun , Warren Alan , Shin Mann Kyoon , Li Lifang
Published: July 2023

Ciliated protozoa (ciliates) are unicellular eukaryotes, several of which are important model organisms for molecular biology research. Analyses of codon usage bias (CUB) of the macronuclear (MAC) genome of ciliates can promote a better understanding of the genetic mode and evolutionary history of these organisms and help optimize codons to improve gene editing efficiency in model ciliates. In this study, the following indices were calculated: the guanine-cytosine (GC) content, the frequency of the nucleotides at the third position of codons (T3, C3, A3, G3), the effective number of codons (ENc), GC content at the 3rd position of synonymous codons (GC3s), and the relative synonymous codon usage (RSCU). Parity rule 2 plot analysis, Neutrality plot analysis, ENc plot analysis, and correlation analysis were employed to explore the main influencing factors of CUB. The results showed that the GC content in the MAC genomes of each of 21 ciliate species, the genomes of which were relatively complete, was lower than 50%, and the base compositions of GC and GC3s were markedly distinct. Synonymous codon analysis revealed that the codons in most of the 21 ciliates ended with A or T and four codons were the general putative optimal codons. Collectively, our results indicated that most of the ciliates investigated preferred using the codons with anof AT-ending and that codon usage bias was affected by gene mutation and natural selection.
Larmor Temperature, Casimir Dynamics, and Planck’s Law
Authors: Ievlev Evgenii , Good Michael R. R.
Published: July 2023

Classical radiation from a single relativistically accelerating electron is investigated where the temperature characterizing the system highlights the dependence on acceleration. In the context of the dynamic Casimir effect with Planck-distributed photons and thermal black hole evaporation, we demonstrate analytic consistency between the ideas of constant acceleration and equilibrium thermal radiation. For ultra-relativistic speeds, we demonstrate a long-lasting constant peel acceleration and constant power emission, which is consistent with the idea of balanced equilibrium of Planck-distributed particle radiation.