bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic survey on data security in wireless body area networks in IoT healthcare system
Authors: Jian Wang , Tabassum Alia , Li Jian Ping
Published: July 2024

In the Internet of Things (IoT) healthcare sector, the wireless body area network (WBAN) is being used to optimize medical results by tracking and treating patients as they go about their daily lives. Health insurance has also been one of the cybercriminal's main goals. The Systematic Review of IoT Healthcare systems particularly wireless body area networks is significant, to reach the benefits and challenges faced by existing methods in the domain. This study provides a systematic survey of WBAN data protection. Various types of devices are used in medical science to detect and diagnose diseases. The network is an integral part of medical science in today's era. In medical sciences, sensors take data from a problematic place like cancerous cells. This research discussed a lot of techniques in the literature review. Most of them are not able to fulfill the requirements. If an unauthorized person reaches the data that can be a severe issue, like the diagnosed disease was blood cancer, and after unauthorized access manipulation can change even the diagnosed issue in the database. A doctor can prescribe the medication based on provided data that has been manipulated by unauthorized persons. Several existing schemes are explored in the literature to determine how the protection of sharing patients' healthcare data can be improved. The systematic literature review (SLR) of multiple security schemes for WBAN is presented in this survey paper.
Impact of IPM practices on microbial population and disease development in transplanted and direct-seeded rice
Authors: Khokhar M. K. , Kumar Rakesh , Kumar Anoop , Sehgal Mukesh , Singh S. P. , Meena P. N. , Singh Niranjan , Acharya L. K. , Birah Ajanta , Singh Kartar , Bana R. S. , Gurjar M. S. , Chander Subhash , Choudhary Manoj
Published: July 2024

Integrated pest management (IPM) is a comprehensive approach to managing diseases, focusing on combining various strategies to reduce pathogen populations effectively and in an environmentally conscious way. We investigated the effects of IPM on beneficial microbial populations and its relationship with pathogen populations in both direct-seeded rice (DSR) and transplanted rice (TR) systems. This study demonstrates that IPM practices have significantly higher populations of beneficial microbes, such as Trichoderma harzianum and Pseudomonas fluorescens, and lower level of the pathogen Fusarium verticillioides compared to non-IPM (farmer practices). The average mean population of T. harzianum was 6.38 × 103 CFU/g in IPM compared to 3.22 × 103 CFU/g in non-IPM during 2019 in TR at Bambawad. P. fluorescens mean population in 2019 was significantly higher in IPM (4.67 × 103 CFU/g) than in non-IPM (3.82 × 103 CFU/g) at the Karnal location in DSR. The F. verticillioides populations were significantly lower in IPM fields (9.46 × 103 CFU/g) compared to non-IPM fields (11.48 × 103 CFU/g) during 2017 at Haridwar in TR. Over three years, a significant increase in the populations of beneficial microbes in IPM plots was observed in all three locations of both TR and DSR, highlighting the sustainable impact of IPM practices. Disease dynamics analysis revealed that IPM effectively managed key diseases in both DSR and TR systems, with significant correlations between microbial density and disease severity. A significant positive correlation was recorded between F. verticillioides population and bakanae incidence at all three locations. Sheath blight incidence was negatively correlated with P. fluorescens population in both TR and DSR. In DSR, bacterial blight and brown spot diseases are reduced with the increased population of T. harzianum. Bioagents T. harzianum and P. fluorescens reduced disease incidence, underscoring the role of beneficial microbes in disease suppression and their importance for sustainable production using IPM practices.
Lupus nephritis kidney biopsy characteristics and preterm birth
Authors: Reynolds Monica L. , Gibson Keisha L. , Manuck Tracy A. , Poulton Caroline J. , Blazek Lauren , Stuebe Alison M. , Hogan Susan L. , Falk Ronald J. , Derebail Vimal K.
Published: July 2024

Individuals with lupus nephritis (LN) are at high risk of adverse maternal and fetal outcomes in pregnancy. Outside of pregnancy, proliferative lesions on kidney biopsies are associated with disease progression, but these have not been consistently associated with increased risk in pregnancy. This retrospective, single-center study examines how histologic findings, the timing from kidney biopsy to pregnancy, and the clinical features in the first trimester are associated with preterm birth among individuals with LN. Among 35 deliveries in 31 women, the mean gestational age at delivery was 33.8 weeks. The presence of a urine protein-to-creatinine ratio >0.5 g/g in the first trimester was associated with preterm delivery (81% vs. 36%, p = 0.04). Preterm birth was more common in individuals with glomerular crescents on biopsy (89% in those with >20% crescents vs. 50% in those with <20%, p = 0.06). A pregnancy occurring within 2 years after a kidney biopsy was more likely to result in preterm birth than if the biopsy was performed more than 2 years prior to conception (82% vs. 23%, p = 0.01). The time from diagnostic biopsy may be a surrogate for disease activity, and a 2-year delay from biopsy might allow sufficient time to achieve disease remission. Overall, these data could aid family planning discussions and promote preconception disease optimization for patients and their providers.
Current state of endovascular treatment of anterior cerebral artery aneurysms
Authors: Li Bingwei , Zhang Kun , Yu Jinlu
Published: July 2024

The locations of anterior cerebral artery (ACA) aneurysms vary, and various aneurysms can occur along the course of the ACA. Ruptured and some unruptured ACA aneurysms may require aggressive treatment to avoid bleeding or rebleeding. Although open surgery is an effective treatment for ACA aneurysms, endovascular treatment (EVT) is becoming an alternative treatment in select cases. EVT techniques for ACA aneurysms often vary and are performed on a case-by-case basis according to the nature and location of the aneurysm. To better understand the EVT strategy for ACA aneurysms, it is necessary to review EVT for ACA aneurysms. In this review, the following topics are discussed: ACA anatomy and anomalies, classifications of ACA aneurysms, the natural history of ACA aneurysms, open surgery and EVT statuses for ACA aneurysms, EVT techniques for various ACA aneurysms, and the prognosis and complications of EVT for ACA aneurysms. According to our review and experience, traditional coiling EVT is still the preferred therapy for most ACA aneurysms. For A1 aneurysms, EVT is challenging. After the selection of appropriate cases, deployment of a flow diverter and Woven EndoBridge device can result in a good prognosis for patients with ACA aneurysms. In addition, parent artery occlusion can be used to treat A1 aneurysms with good collateral circulation and some distal ACA aneurysms. In general, EVT is gaining popularity as an alternative treatment option for ACA aneurysms.
A real-world data analysis of ocular adverse events linked to anti-VEGF drugs: a WHO-VigiAccess study
Authors: Li Chen , Lu Yicheng , Song Ziyue , Liu Yueqi
Published: July 2024

Introduction

Vascular endothelial growth factor (VEGF) is key to wet age-related macular degeneration (wAMD). Anti-VEGF drugs are the main treatment in clinics. This study assessed ocular adverse events (AE) from anti-VEGF drugs in VigiAccess, WHO’s database, and compared adverse drug reaction (ADR) profiles of four drugs to aid personalized treatment choices for optimal benefit and safety.

Methods

The design was a descriptive retrospective study. We observed four anti-VEGF drugs commonly used in the clinical treatment of wAMD, and their ADR reports came from WHO-VigiAccess. The collected data included the age group, gender, and regional data, as well as the data of disease systems and symptoms caused by ADR recorded in the annual ADR reports and reports received by the WHO. We observed the overall characteristics of the ADR reports of these drugs, then explored the distribution of 27 SOCs of these drugs. Subsequently, we compared the most common ocular ADRs of the drugs. Finally, we compared the commonalities and differences of ocular ADRs related to the drugs.

Results

Overall, 57,779 AE associated with the four anti-VEGF drugs were reported. The results showed that the number of females experiencing ADRs (67.83%) was significantly higher than males (32.17%), the age group with the highest reported incidence was over 75 years old. More than half of the ADR reports came from the Americas (50.86%). The five most common types of AE were: eye disorders (43.56%), general disorders and administration site conditions (34.47%), injury poisoning and procedural complications (13.36%), infections and infestations (11.61%), nervous system disorders (9.99%). Compared with the other three inhibitors, brolucizumab had a significantly higher rate of ocular ADR reports. The most common ocular ADRs of these four anti-VEGF drugs were mostly related to visual impairment, vision blurred, and blindness. However, there is still a disparity of ADRs between different drugs.

Conclusion

The presence of ocular AEs when using anti-VEGF drugs to treat wAMD in clinical practice should attract clinical attention. Clinicians should use these expensive drugs more rationally based on the characteristics of ADRs and develop personalized treatment plans for patients.
Salvianolic acid B in fibrosis treatment: a comprehensive review
Authors: Liang Qingzhi , Liu Xiaoqin , Peng Xi , Luo Ting , Su Yi , Xu Xin , Xie Hongyan , Gao Hong , Chen Zhengtao , Xie Chunguang
Published: July 2024

Fibrosis is a public health issue of great concern characterized by the excessive deposition of extracellular matrix, leading to the destruction of parenchymal tissue and organ dysfunction that places a heavy burden on the global healthcare system due to its high incidence, disability, and mortality. Salvianolic acid B (SalB) has positively affected various human diseases, including fibrosis. In this review, we concentrate on the anti-fibrotic effects of SalB from a molecular perspective while providing information on the safety, adverse effects, and drug interactions of SalB. Additionally, we discuss the innovative SalB formulations, which give some references for further investigation and therapeutic use of SalB’s anti-fibrotic qualities. Even with the encouraging preclinical data, additional research is required before relevant clinical trials can be conducted. Therefore, we conclude with recommendations for future studies. It is hoped that this review will provide comprehensive new perspectives on future research and product development related to SalB treatment of fibrosis and promote the efficient development of this field.
MOSkin dosimetry for an ultra-high dose-rate, very high-energy electron irradiation environment at PEER
Authors: Cayley James , Tan Yaw-Ren E. , Petasecca Marco , Cutajar Dean , Breslin Thomas , Rosenfeld Anatoly , Lerch Michael
Published: July 2024

FLASH radiotherapy, which refers to the delivery of radiation at ultra-high dose-rates (UHDRs), has been demonstrated with various forms of radiation and is the subject of intense research and development recently, including the use of very high-energy electrons (VHEEs) to treat deep-seated tumors. Delivering FLASH radiotherapy in a clinical setting is expected to place high demands on real-time quality assurance and dosimetry systems. Furthermore, very high-energy electron research currently requires the transformation of existing non-medical accelerators into radiotherapy research environments. Accurate dosimetry is crucial for any such transformation. In this article, we assess the response of the MOSkin, developed by the Center for Medical Radiation Physics, which is designed for on-patient, real-time skin dose measurements during radiotherapy, and whether it exhibits dose-rate independence when exposed to 100 MeV electron beams at the Pulsed Energetic Electrons for Research (PEER) end-station. PEER utilizes the electron beam from a 100 MeV linear accelerator when it is not used as the injector for the ANSTO Australian Synchrotron. With the estimated pulse dose-rates ranging from (7.84±0.21)×105 Gy/s to (1.28±0.03)×107 Gy/s and an estimated peak bunch dose-rate of (2.55±0.06)×108 Gy/s, MOSkin measurements were verified against a scintillating screen to confirm that the MOSkin responds proportionally to the charge delivered and, therefore, exhibits dose-rate independence in this irradiation environment.
Comparison of acute physiological responses between one long and two short sessions of moderate-intensity training in endurance athletes
Authors: Kjøsen Talsnes Rune , Torvik Per-Øyvind , Skovereng Knut , Sandbakk Øyvind
Published: July 2024

Purpose

To compare acute physiological responses and perceived training stress between one long and two short time- and intensity-matched sessions of moderate-intensity training in endurance athletes.

Methods

Fourteen male endurance athletes (VO2max: 69.2 ± 4.2 mL·min−1·kg−1) performed one 6 × 10-min interval session (SINGLE) and two 3 × 10-min interval sessions interspersed with 6.5 h recovery (DOUBLE) of moderate-intensity training on two separate days, while running in the laboratory, using a counterbalanced cross-over trial. The two training days were separated into a first part/session (interval stage 1–3) and second part/session (interval stage 4–6). Respiratory variables, heart rate (HR), blood lactate concentrations (BLa), and rating of perceived exertion (RPE) were collected during sessions, whereas supine heart rate (HR) was assessed in a 60-min recovery period following sessions. Measures of perceived training stress (1–10) were assessed in the morning of the subsequent day.

Results

HR, Bla, and RPE increased in the second compared to first part of SINGLE (168 ± 7 vs. 173 ± 7 bpm, 2.60 ± 0.75 vs. 3.01 ± 0.81 mmol·L−1, and 13.4 ± 1.0 vs. 14.8 ± 1.1-point, respectively, all p < 0.05). HR and Bla decreased in the second compared to first session of DOUBLE (171 ± 9 vs. 166 ± 9 bpm and 2.72 ± 0.96 vs. 2.14 ± 0.65 mmol·L−1, respectively, both p < 0.05). SINGLE revealed higher supine HR in the recovery period following sessions (65.4 ± 2.5 vs. 60.7 ± 2.5 bpm p < 0.05), session RPE (sRPE, 7.0 ± 1.0 vs. 6.0 ± 1.3-point, p = .001) and sRPE training load (929 ± 112 vs. 743 ± 98, p < 0.001) compared to DOUBLE. In the subsequent morning, increased levels of perceived fatigue and muscle soreness were observed following SINGLE compared to DOUBLE (7.0 ± 2.5 vs. 8.0 ± 1.0-point, p = .049 and 6.0 ± 2.5 vs. 7.0 ± 2.5-point, p = .002, respectively).

Conclusion

One long moderate-intensity training session was associated with a duration-dependent “drift” in physiological responses compared to two short time- and intensity-matched sessions, thereby suggesting a higher overall training stimulus. Simultaneously, the lower cost of the two shorter sessions indicates that such organization could allow more accumulated time at this intensity. Overall, these findings serve as a starting point to better understand the pros and cons of organizing moderate-intensity training as one long versus shorter sessions performed more frequently (e.g., as “double threshold training”) in endurance athletes.
Rhizosphere effects and microbial N limitations drive the root N limitations in the rhizosphere during secondary succession in a Pinus tabuliformis forest in North China
Authors: Duan Songlan , Guo Jinping , Zhang Yunxiang , Liu Libao , Wang Rui , Zheng Rongrong
Published: July 2024

Introduction

Rhizosphere effects (REs) have recently been identified as important regulators of root and microbial nutrient acquisition and are positively involved in nutrient cycling of belowground carbon (C), nitrogen (N), and phosphorus (P). Nutrient conditions of the fine roots and soil N are likely to influence REs. Still, it is unclear how REs of soil nutrients themselves variably impact the supply of nutrients to plants in terms of the responses to soil N due to succession.

Methods

In this study, we applied both fine roots and extracellular enzymes for vector analysis and stoichiometry of N:P to explore the metabolic limitations of roots and rhizospheric soil microbes and their relationships with REs across five levels of soil N (0, 5, 10, 15, and 20 kg N m−2 year−1) along successional age classes of 42, 55, and 65 years in a Pinus tabuliformis forest.

Results

Overall, the metabolism of root and rhizospheric soil microbes was mediated by soil N. N limitation of roots initially decreased before increasing, whereas that of microbes demonstrated opposite trends to the N levels owing to competition for inorganic N between them by REs of NO3−–N. However, N limitations of both roots and microbes were alleviated in young stands and increased with succession after the application of N. In addition, root N limitations were manipulated by REs of three different soil N-related indicators, i.e., total N, NH4+–N, and NO3−–N. Rhizospheric soil microbial N limitation was almost unaffected by REs due to their strong homeostasis but was an important driver in the regulation of root N limitation.

Discussion

Our results indicated that successional age was the most critical driver that directly and indirectly affected root N metabolism. However, the level of N application had a slight effect on root N limitation. Microbial N limitation and variations in the REs of N indicators regulated root N limitation in the rhizosphere. As a result, roots utilized REs to sequester N to alleviate N limitations. These findings contribute to novel mechanistic perspectives on the sustainability of N nutrition by regulating N cycling in a system of plant–soil–microbes in the rhizosphere to adapt to global N deposition or the heterogeneous distribution of bioavailable soil N with succession.
Exploring college students’ resistance to mandatory use of sports apps: a psychological reactance theory perspective
Authors: Guo Jian
Published: July 2024

Introduction

To improve the physical fitness of college students, numerous Chinese universities have mandated students to use sports apps for running on campus. However, this has led to widespread resistance among students.

Methods

To gain a deep understanding of the potential reasons for student resistance, we have developed a conceptual model based on psychological reactance theory. Specifically, we conducted a questionnaire survey involving 449 Chinese college students, using partial least squares structural equation modeling to test and analyze the research model and its related hypotheses.

Results

Our results reveal that: (1) Psychological reactance poses a potential reason for students’ resistance to mandatory use of sports apps, and it has a significant negative impact on students’ attitudes and behavioral intentions. (2) Students’ perceived threat to freedom and reactance proneness are two important antecedents of psychological reactance, which can account for 51% (R2 = 0.51) of the variance in psychological reactance. Furthermore, the results indicate that students’ reactance proneness has a positive impact on perceived threats to freedom. (3) The mandatory use of sports apps leads students to have two different conditions: mandated-acceptance and mandated-rejection, both of which have a positive impact on the antecedents of psychological reactance.

Discussion

These findings provide insights into the psychological processes underlying students’ resistance to mandatory use of sports apps, facilitating the application of sports apps in intervention measures that improve health and fitness. Furthermore, this study is the first to apply psychological reactance theory to mandatory exercise behavior, contributing to the reactance literature.
A narrative review of wastewater surveillance: pathogens of concern, applications, detection methods, and challenges
Authors: Singh Surabhi , Ahmed Amina Ismail , Almansoori Sumayya , Alameri Shaikha , Adlan Ashraf , Odivilas Giovanni , Chattaway Marie Anne , Salem Samara Bin , Brudecki Grzegorz , Elamin Wael
Published: July 2024

Introduction

The emergence and resurgence of pathogens have led to significant global health challenges. Wastewater surveillance has historically been used to track water-borne or fecal-orally transmitted pathogens, providing a sensitive means of monitoring pathogens within a community. This technique offers a comprehensive, real-time, and cost-effective approach to disease surveillance, especially for diseases that are difficult to monitor through individual clinical screenings.

Methods

This narrative review examines the current state of knowledge on wastewater surveillance, emphasizing important findings and techniques used to detect potential pathogens from wastewater. It includes a review of literature on the detection methods, the pathogens of concern, and the challenges faced in the surveillance process.

Results

Wastewater surveillance has proven to be a powerful tool for early warning and timely intervention of infectious diseases. It can detect pathogens shed by asymptomatic and pre-symptomatic individuals, providing an accurate population-level view of disease transmission. The review highlights the applications of wastewater surveillance in tracking key pathogens of concern, such as gastrointestinal pathogens, respiratory pathogens, and viruses like SARS-CoV-2.

Discussion

The review discusses the benefits of wastewater surveillance in public health, particularly its role in enhancing existing systems for infectious disease surveillance. It also addresses the challenges faced, such as the need for improved detection methods and the management of antimicrobial resistance. The potential for wastewater surveillance to inform public health mitigation strategies and outbreak response protocols is emphasized.

Conclusion

Wastewater surveillance is a valuable tool in the fight against infectious diseases. It offers a unique perspective on the spread and evolution of pathogens, aiding in the prevention and control of disease epidemics. This review underscores the importance of continued research and development in this field to overcome current challenges and maximize the potential of wastewater surveillance in public health.
In vitro comparative quality assessment of different brands of hydrochlorothiazide tablets marketed in Northeast Ethiopia
Authors: Wondmkun Yehualashet Teshome , Desta Haile Kassahun , Ali Yimer Seid , Tsige Abate Wondesen , Ayenew Kassahun Dires , Endalifer Bedilu Linger , Dagnew Samuel Berihun
Published: July 2024

Background

This study aimed to comparatively evaluate the quality and physicochemical bioequivalence of commercially available brands of hydrochlorothiazide (HCT) tablets in community pharmacies in Dessie town, Northeast Ethiopia.

Methods

Experimental cross-sectional study design was applied using pharmacopeia and non-pharmacopeia methods. The difference (f1) and similarity (f2) factors were calculated to assess the in vitro bioequivalence of generic products with the comparator.

Result

The study results revealed that all investigated brands contained the required active pharmaceutical ingredients (APIs). The friability test results were concordant with the United States Pharmacopeia (USP) (<1%) for eight brands; however, brand NF3 (1.36%) failed to pass the specification limit. The hardness levels of the brands NF3 (24.20 ± 7.32 N), NF5 (32.19 ± 4.78 N), and NF9 (35.02 ± 3.12 N) were below the specification limit (39.23 N, USP 2019). The weight variation results of all generic products complied with the USP specification requirement. In the quantitative assay results, the minimum and maximum API contents were 97.4 ± 0.02 (NF6) and 105.8 ± 0.02 (NF8), respectively, which are within the limit specified by the USP (90%–110%). Similarly, all samples met the disintegration time limit (i.e., ≤30 min) and drug-releasing tolerance limit (API released more than 60% within 60 min) requirements. The f2 values were >50, and the f1 values were <15 for all sampled brands.

Conclusion

The majority of the sampled brands of HCT tablets met the quality requirements as per USP official test specifications. From the similarity and difference factor values, all studied brands were shown to be equivalent.
Effect of oregano essential oil on intestinal immunoglobulin G in Holstein dairy bulls
Authors: Xu Meiling , Zhang Wangdong , Kong Fanyun , Wang Baoshan , Pan Jing , Shi Jinping , Liu Qiyan , He Pengjia , Ma Yue , Cheng Qiang , Zhang Zhao , Lei Zhaomin
Published: July 2024

Introduction

Immunoglobulin G (IgG) is important in mediating humoral immunity and in the maintenance of immune homeostasis in the intestinal mucosa. Oregano essential oil (OEO) is a natural herbal extract that possesses antimicrobial, antioxidant, anti-inflammatory, and immunomodulatory properties. As the effects of OEO on intestinal mucosal immunity in Holstein dairy bulls remained unclear, we investigated the effect of dietary supplementation of OEO on IgG levels and IgG+ cells residing in the intestinal tract in Holstein dairy bulls.

Methods

Twelve Holstein bulls in good health of approximately 10 months of age were selected for the experiment and randomly equally divided into two groups. The control (CK) group was fed a basal ration, and in the OEO group, the basal ration was supplemented with OEO (20 g/head/day). After 300 days of feeding, tissue samples of the jejunum, ileum, and colon of the bulls in each group were collected for histopathological analysis, immunohistochemistry, and enzyme-linked immunosorbent assays, respectively.

Results

The jejunum, ileum, and colon of bulls in the CK group had obvious pathological damage, whereas the structure of each intestinal segment was clear and intact. In the OEO group, pathological damage was significantly reduced. IgG+ plasma cells were diffusely distributed in the lamina propria of the jejunum, ileum, and colon in the CK and OEO groups, with no significant difference between the groups. OEO supplementation significantly reduced the number of IgG+ plasma cells in each intestinal segment, with the highest decrease rate being noted for the ileum (22.87%), followed by the colon (19.45%) and jejunum (8.52%). ELISA test results and immunohistochemical results were mutually verified. The change in IgG content was consistent with the trend of change in the number of IgG+ plasma cells.

Discussion

Our findings suggest that OEO supplementation does not alter the diffuse spatial distribution of IgG+ plasma cells in the intestines of Holstein dairy bulls, but lowers immunoglobulin levels to normal levels, significantly reduces intestinal damage, and may enhance mucosal immune defence barrier function by inhibiting inflammatory reactions.
Definiowanie samobójstwa w grupach medycznych i niemedycznych – analiza badań fokusowych
Authors: Kwiatkowska Anita
Published: July 2024

Nowadays, the socio-cultural image of suicide indicates a greater acceptance of the act, as well as its linguistic neutralization. The discernible differences with respect to word-formation and definitions used in the spoken language seem to be particularly significant. The paper discusses this issue in relation to groups of students of medical studies (nursing, midwifery, medicine, emergency medical services), social studies (journalism) and specialists (academic employees, doctors, midwives and nurses, psychiatrists, psychiatric hospital employees). The analysis of attitudes towards suicide exhibited in spoken language was based on focus group interviews, which enabled the reconstruction of deeply rooted ways of thinking and perceiving phenomena in research-controlled conditions. The choice of words, topics, and the way of defining suicide, as well as related issues, reflected the state of knowledge about suicidology and (underlying) emotions or attitudes.
Research on the Mechanism of the Skidding Device of Bulk Grain into Silo
Authors: Wang Mingxu , Li Saiqiang , Zhao Haojun , Song Zhijie , Liu Kunlun , Wu Jianzhang
Published: July 2024

In the field of handling, storage and transportation, chutes are used to transfer bulk solids between conveyors and warehouses. In these systems, traditional analytical methods based on the principles of continuum mechanics approximate an accelerated flow that contains the physical body solid properties obtained from standardized tests. Because it is difficult to physically observe the flow inside the transfer structure, there have been few studies to validate the method at full scale. In contrast, discrete element modeling (DEM) allows flow visualization through a transfer chute and qualitative and quantitative analysis if accurate simulation parameters are selected. In order to adapt to the needs of modern intelligent warehousing, we reduced the grain crushing and damage in the process of grain storage. To design and investigate the motion performance of grain particles in a sliding dustpan, this paper utilizes rocky simulation technology, combined with the corresponding bench experiments, to study the impact of the angle arrangement of the dustpan, and to verify the results of the simulation analysis based on the stress–strain analysis of the particle impact. It was found that when the angle of the dustpan arrangement was 40 degrees, the flow of all particles had a better performance in terms of pass ability and energy loss. In the continuous cycle obtained from the simulation, the particle group state at each moment is almost the same as the particle characteristics in the experiment, indicating that the angle of the bucket has an effect on the particle permeability. In this paper, the results of the study on the state of the grain group on the silo device will provide a useful reference for the design of a grain silo device.
NOTCH1- and CD117-Positive Stem Cells in Human Endometriosis and Adenomyosis Lesions
Authors: Metodiev Dimitar , Parvanov Dimitar , Ruseva Margarita , Ganeva Rumiana , Handzhiyska Maria , Vidolova Nina , Chavoushian Ani , Hadjidekova Savina , Stamenov Georgi
Published: July 2024

Adenomyosis and endometriosis are distinct gynecological disorders characterized by ectopic growth of endometrial tissue. Their etiology remains unclear, but stem cells have been implicated in both. The aim of this study was to investigate and compare the quantity of NOTCH1+ and CD117+ stem cells in endometriosis and adenomyosis lesions. Immunohistochemical staining of ectopic endometrium biopsies using antibodies against NOTCH1 and CD117 was performed. The quantity and spatial distribution of endometrial stromal cells positive for these markers were determined and compared between endometriosis and adenomyosis lesions. Additionally, their quantities were compared between endometriosis lesion types. Mann–Whitney U test showed that the median percentages of both NOTCH1+ and CD117+ cells in the endometriosis lesions were significantly higher than those in the adenomyosis lesions (2.26% vs. 0.13%, p = 0.002 and 0.44% vs. 0.26%, p = 0.016, respectively). Spearman’s test showed a positive correlation between NOTCH1+ and CD117+ cells in endometriosis lesions (R = 0.45, p = 0.027) but no significant correlation in adenomyosis lesions (R = −0.11, p = 0.69). The quantity of both stem cell types was highest in extragenital endometriotic lesions. Unlike adenomyosis, endometriosis lesions are associated with higher quantities of NOTCH1+ and CD117+ stem cells and a coordinated increase in their number. These findings support the distinct origin of the two conditions.
Improved Model-Free Predictive Control of a Three-Phase Inverter
Authors: Nauman Muhammad , Shireen Wajiha
Published: July 2024

Model predictive control (MPC) performance depends on the accuracy of the system model. Moreover, the optimization algorithm of MPC requires numerous online computations. These inherent limitations of MPC hinder its application in power electronics systems. This paper proposes a two-part solution for these challenges for a three-phase inverter with an output LC filter. The first part of the control scheme is a linear and modified model-free approach based on the auto-regressive structure (ARX) with exogenous input. The second part is the computationally efficient optimization algorithm based on the active set method to solve the optimization problem of the MFPC. The objective of the control scheme is to regulate the output voltages of the inverter in the presence of constraints. The constraints are the maximum admissible filter current and optimal duty cycle to avoid any damage to the system. To validate the performance of the proposed control scheme, simulations and hardware-in-loop (HIL) real-time investigations have been performed, comparing the results of the proposed approach with the model-based predictive control. The results showcase the computational efficiency and effectiveness of the MFPC approach, demonstrating its potential for overcoming the limitations of traditional MPC in power electronics systems.
Manuscripts and Creative Industries: Batik as a Medium for Introducing Ulu Script in South Sumatra
Authors: Kusman Agus , Saepudin Didin
Published: July 2024

This study aims to describe the efforts made by the South Sumatra Ulu Script Lovers' Association in introducing the Ulu Script to the public through the creative industry, specifically batik. The research used a case study research method, conducted over four months, with the primary data source being the Ulu script. The motivation for this research is the limited public knowledge about the Ulu script and the innovative approach taken by the South Sumatra Ulu Script Lovers' Association in introducing the script through batik. The findings of the study are as follows: First, the South Sumatra Ulu Script Lovers' Association introduced the Ulu Script through the creative industry, namely batik. Second, the community was introduced to the Ulu script through learning and developing the script. Third, the community was introduced to natural dyes for creating batik motifs derived from the Ulu script. Fourth, the batik motifs based on the Ulu script included the Ulu Bunga Enim Motif, the Ulu Kujur Motif, the Ulu Komering Dam Bridge Motif, the Ulu Duku Komering Tree Motif, the Ulu Ampera Bridge Motif, and the Ulu Dragon Motif.
PENGARUH WAKTU TUNGGU TERHADAP MINAT KUNJUNGAN ULANG YANG DIMEDIASI KEPUASAN PASIEN
Authors: Dwi Tinaningsih Morita , Syaodih Erliany , Hadian Rahim Agus
Published: July 2024

Waktu tunggu yang lama dalam proses mendapatkan pelayanan bagi pasien di Rumah Sakit dapat menyebabkan ketidakpuasan dan mempengaruhi pasien untuk melakukan kunjungan ulang rawat jalan.  Penelitian ini bertujuan untuk mengetahui pengaruh waktu tunggu terhadap kunjungan ulang pasien yang dimoderasi oleh kepuasaan pasien mendapatkan pelayanan. Desain penelitian ini adalah jenis studi survei kuantitatif dengan pendekatan cross-sectional. Studi tersebut dilakukan di RSUD Panglima Sebaya pada bulan November 2023. Metode penelitian menggunakan purposive sampling, dengan memilih subjek yang memenuhi kriteria responden/sampel sebanyak 376 Pasien Rawat Jalan. Analisis data yang digunakan yaitu uji regresi logistic. Hasil penelitian menunjukkan bahwa pengaruh waktu tunggu terhadap kepuasan pasien diperoleh nilai p-value sebesar 0,000 (<0,05), dan pengaruh waktu tunggu terhadap kunjungan ulang pasien nilai p-value sebesar 0,000 (<0,05), serta pengaruh kepuasan pasien terhadap kunjungan ulang diperoleh nilai p-value sebesar 0,000 (<0,05). Kesimpulan dalam penelitian ini yaitu ada pengaruh waktu tunggu terhadap kepuasan pasien, ada pengaruh waktu tunggu terhadap kunjungan ulang pasien dan ada pengaruh kepuasan pasien terhadap kunjungan ulang.
 
 
Long waiting times in the process of getting services for patients at the hospital can cause dissatisfaction and influence patients to make outpatient re-visits. This study aims to determine the effect of waiting time on patient revisits moderated by patient satisfaction with service. This research design is a type of quantitative survey study with a cross-sectional approach. The study was conducted at Panglima Sebaya Hospital in November 2023. The research method uses purposive sampling, by selecting subjects who meet the criteria for respondents/samples of 376 outpatients. The data analysis used was logistic regression test. The results showed that the effect of waiting time on patient satisfaction obtained a p-value of 0.000 (<0.05), and the effect of waiting time on patient revisit p-value of 0.000 (<0.05), and the effect of patient satisfaction on revisit obtained a p-value of 0.000 (<0.05). The conclusion in this study is that there is an effect of waiting time on patient satisfaction, there is an effect of waiting time on patient revisits and there is an effect of patient satisfaction on revisits.
ANALISIS KEPEMIMPINAN KEWIRAUSAHAAN PADA STARTUP BERBASIS METAVERSE DI INDONESIA
Authors: Novel Nurillah Jamil Achmawati , Tresna Pratami Wulan
Published: July 2024

This research focuses on analyzing the dimensions of entrepreneurial leadership in metaverse-based startups in Indonesia. The aim of the research is to determine the implementation of entrepreneurial leadership in startups, using eight dimensions of leadership according to Bagheri & Harrison (2020): Framing Challenges, Absorbing Uncertainty, Underwriting, Building Commitment, Defining Gravity, Opportunity Identification and Exploitation, Orientation Toward Learning, and Creative Collective Self-Efficacy. The research method uses a mixed approach, with quantitative data collection through questionnaires filled out by 156 respondents from the Bandung Startup community, and qualitative data through in-depth interviews with 11 informants. The research results show that the entrepreneurial leadership dimension in metaverse startups received very high ratings, with an average score above 4.3 on a 1-5 Likert scale. The main findings from interviews indicate that metaverse-based startups are generally full-time remote, flexible, and oriented towards completing work targets. Additionally, opportunities in the metaverse industry to generate revenue and grow businesses are still vast, requiring constant innovation from leaders. In conclusion, entrepreneurial leadership plays an important role in managing the dynamics of metaverse-based startups, accompanied by high adaptation and innovation to achieve optimal performance in a rapidly developing ecosystem.
PENGARUH PROSES PRODUKSI DAN PENGENDALIAN KUALITAS TERHADAP KUALITAS PRODUK YHA DI PT. FURUKAWA AUTOMOTIVE SYSTEM INDONESIA CIKARANG
Authors: Subagiyo  , Suci Desvika
Published: July 2024

The quality of a product is one of the most important factors in the industrial world as in PT. Furukawa Automotive System Indonesia. The company always tries to maintain the quality of its products, but inreality things don't go smoothly. Every month there are still a large number of damaged products (NG) both in the production process and in quality control that are not optimal. There fore the purpose of this research is to find out how much influence the production process and quality control have on the quality of the product produced either partially or simultaneously. This study uses a quantitative approach with primary data as a source of data obtained from the results of the questionnaire. Data analysis methods in this study are validity test, reliability test, classic assumption test which consists of normality test, heteroscedasticity test, multicollinearity test, linearity test, hypothesis test and determination test. The results of this study indicate that (1) the production process variable has a positive and significant effect on the product quality of PT. Fasi, (2) the quality control variable has a positive and significant effect on the product quality of PT. Fasi, (3) the production process variables and quality control variables together have an influence and are significant on the product quality of PT. Fasi.
Effect of Visible and Infrared Photobiomodulation on Diabetic Foot Ulcers
Authors: Tabeie Faraj , Tabakhha Sara , Sadeghi Soheila , Ebadi Alireza
Published: July 2024

Introduction: Diabetes is a highly prevalent disease worldwide. Despite routine treatments, there is no effective treatment approach for patients with diabetic foot ulcers (DFUs). A new approach to reduce complications and control DFU is low-level laser therapy (LLLT). In the present study, we evaluated the therapeutic effects of LLLT on the symptoms of DFU patients. Methods: Sixty diabetic patients with DFU were included in this randomized clinical trial and were randomly allocated into two groups of laser (n=30) and control (n=30) with signed written consent. The LLLT group underwent visible and infra-red laser therapy and conventional medical treatment, while the control group received only conventional medical treatment. The total laser irradiation sessions of the patients were 20 sessions, (three sessions a week) and each session lasted for 30 minutes over the entire surface of the wound. The power density per session for each laser was calculated to be 35.65 mW/cm2 with an energy density of 64.17 J/cm2 . Results: The mean area of ulcers in the LLLT group reduced significantly (P<0.001) from 441.7±365.5 mm2 before LLLT to 163.9±213.9 mm2 from the baseline up to the last session of LLLT, indicating a 62.99% reduction in mean ulcer area. In the control group, the mean ulcer area did not change significantly. Wagner’s classification of the patients in the LLLT group reduced to lower grades significantly (P<0.01), while the classification moved towards higher grades in the control group (P<0.08). Conclusion: In this study, we showed the effectiveness of LLLT in the reduction of the surface and depth of DFUs. The results documented that patients experienced significant improvements in the healing of their foot ulcers after laser therapy. It is recommended that the LLLT be considered as a non-invasive method for the treatment of DFU patients.
Effect of Photodynamic Therapy with Four Light-Sensitive Materials on the Bond Strength of Fiber Posts to Root Dentin
Authors: Hashemikamangar Sedighe Sadat , Pourahmadi Shadi , Chiniforush Nasim
Published: July 2024

Introduction: Fiber-reinforced composite posts (FRCP) have become popular due to their multiple advantages in teeth with extensive crown destruction. Proper disinfection is essential for the successful bonding of these posts. Commonly used solutions for cleaning and disinfecting the root canals adversely affect the bond strength (BS). Photodynamic therapy is an alternative method for irrigating the root canal and disinfecting the post space.This study was designed to evaluate the impact of photodynamic therapy on the BS of fiber posts to root canal dentin. Methods: Human maxillary canines were recruited for this study. The tooth crowns were removed at the cervical line and endodontically treated. After fiber post spaces were prepared, the teeth were assigned to five groups based on the light-sensitive material: deionized water, indocyanine green and 810-nm laser, methylene blue and 660-nm laser, toluidine blue and 635-nm laser, curcumin and LED. The posts were cemented after photodynamic therapy. Cervical, middle, and apical samples were prepared by transverse sectioning. Push-out bond strength (PBS) values were measured in a universal testing machine. Finally, the data underwent statistical analyses with ANOVA and Howell-Games tests. Results: One-way ANOVA revealed no significant differences between the groups (P<0.001). The Games-Howell test showed that curcumin (7.23±3.75) and the control group (5.92±4.04) had a similar BS (P>0.005). The BS was lower in the methylene blue (3.34±2.15), indocyanine green (2.59±3.16), and toluidine blue (2.45±1.73) groups than in the control group (P<0.005). Conclusion: Unlike other light-sensitive materials, curcumin did not adversely affect the BS.
Analysis of the State of Small Business by Subjects of the Far Eastern Federal District
Authors: Сергиенко Е.Е.
Published: July 2024

В статье рассмотрены методы, позволяющие оценить состояние малого предпринимательства, дана количественная оценка состояния малого предпринимательства ДВФО с использованием таких показателей, как количество малых предприятий, численность занятых на малых предприятиях, объем инвестиций в основной капитал малых предприятий, оборот малых предприятий и фонд заработной платы на малых предприятиях. Также проведен анализ состояния малого предпринимательства дальневосточного региона с применением метода максимина, ранее мало использовавшегося для оценки состояния малого предпринимательства в регионах. Рассмотрены методы государственной поддержки, которые способствовали достижению высоких результатов развития малого предпринимательства.

The article discusses methods for assessing the state of small businesses, gives a quantitative assessment of the state of small businesses in the Far Eastern Federal District (FEFD) using indicators such as the number of small enterprises, the number of people employed in small enterprises, the volume of investments in fixed capital of small enterprises, the turnover of small enterprises and the wage fund for small businesses. The analysis of the state of small business in the Far Eastern region was also carried out using the maximin method, previously little used for assessing the state of small business in the regions. The methods of state support, which contributed to the achievement of high results of development of small business, are considered.
Methodical Approach to the Analysis of Solvency and Liquidity of the Organization
Authors: Резниченко С.С. , Тахумова О.В. , Попова К.А.
Published: July 2024

В работе рассматриваются основы анализа ликвидности и платежеспособности предприятия. Раскрываются сущность, а также взаимосвязь платежеспособности и ликвидности как одних из основных направлений финансового состояния. Представлен алгоритм определения потенциальной платежеспособности организации, рассмотрен механизм повышения финансовой отдачи активов.

The paper discusses the basics of analysis of liquidity and solvency of the enterprise. The essence, as well as the relationship of solvency and liquidity, as one of the main directions of financial condition, is revealed. The algorithm of determination of potential solvency of the organization is presented, the mechanism of increase of financial return of assets is considered.
Assessment of Investment Attractiveness of PJSC «Mostotrest»
Authors: Творищенко Г.Р. , Касимова Д.Ф.
Published: July 2024

В статье проведена оценка стоимости ПАО Мостотрест методом компаний-аналогов. В качестве компаний-аналогов выбраны иностранные предприятия, что подчеркивает, что компания инвестиционно привлекательна не только для российских инвесторов.

The article assesses the value of PJSC Mostotrest by the method of analogue companies. Foreign companies have been selected as analogues, which emphasizes that the company is attractive for investment not only for Russian investors.
Research of Problems of Development of Entrepreneurship in the Service Sector
Authors: Закирова И.Р.
Published: July 2024

В статье рассмотрены основные проблемы, снижающие развитие потенциала предпринимательских структур сферы услуг и пути их решения. Обозначена главная причина, сдерживающая развитие предпринимательства в сфере услуг, низкий уровень конкурентного потенциала организации. Формирование и развитие конкурентного потенциала становится императивом устойчивого развития предпринимательских структур сферы услуг.

The article deals with the main problems that reduce the development of the potential of business structures in the service sector and ways to solve them. The main reason constraining the development of entrepreneurship in the service sector, the low level of competitive potential of the organization. The formation and development of competitive potential is becoming an imperative of sustainable development of business structures in the service sector.