bluuebunny/crossref_metadata_2025 huggingface dataset:
Toxic effects of detected pyrethroid pesticides on honeybee (Apis mellifera ligustica Spin and Apis cerana cerana Fabricius)
Authors: Liu Qiongqiong , He Qibao , Zhang Shiyu , Chai Yuhao , Gao Quan , Xiao Jinjing , Fang Qingkui , Yu Linsheng , Cao Haiqun
Published: October 2022

To obtain the presence of environmental contaminants in honeybee and compare the toxicity of the detected pesticides to Apis mellifera ligustica Spin and Apis cerana cerana Fabricius. In this work, 214 honeybee samples were collected to simultaneous monitoring 66 pesticides between 2016 and 2017 in China. A modified QuEChERS extraction method coupled with multi-residue analytical methods by Ultra-high-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) and Gas chromatography-mass spectrum (GC–MS). Among, four pyrethroid pesticides were selected to test and compare the acute oral toxicities of two honeybees. And the survival risk of beta-cypermethrin was analyzed to them. Using this method, 21 compounds were detected, including 3 neonicotinoids, 5 pyrethroids, 5 organophosphorus and 8 others. Importantly, detected frequencies of pyrethroid pesticides were accounted for 53.3%. Among, acute toxicity values (LD50) of four pyrethroid pesticides to the A.m. ligustica were higher than of that the A.c. cerana. When they were exposed to the same concentration of beta-cypermethrin (0.2906 mg/L), the survival rate of the A.m. ligustica (40.0%) was higher than the A.c. cerana (18.9%). Our work is valuable to analyze multiple pesticide residues of honeybees and evaluate the survival risk of two honeybee species, which also provides a basis for the risk assessment.
Artificial intelligence in (gastrointestinal) healthcare: patients’ and physicians’ perspectives
Authors: van der Zander Quirine E. W. , van der Ende - van Loon Mirjam C. M. , Janssen Janneke M. M. , Winkens Bjorn , van der Sommen Fons , Masclee Ad. A. M. , Schoon Erik J.
Published: October 2022

Artificial intelligence (AI) is entering into daily life and has the potential to play a significant role in healthcare. Aim was to investigate the perspectives (knowledge, experience, and opinion) on AI in healthcare among patients with gastrointestinal (GI) disorders, gastroenterologists, and GI-fellows. In this prospective questionnaire study 377 GI-patients, 35 gastroenterologists, and 45 GI-fellows participated. Of GI-patients, 62.5% reported to be familiar with AI and 25.0% of GI-physicians had work-related experience with AI. GI-patients preferred their physicians to use AI (mean 3.9) and GI-physicians were willing to use AI (mean 4.4, on 5-point Likert-scale). More GI-physicians believed in an increase in quality of care (81.3%) than GI-patients (64.9%, χ2(2) = 8.2, p = 0.017). GI-fellows expected AI implementation within 6.0 years, gastroenterologists within 4.2 years (t(76) =  − 2.6, p = 0.011), and GI-patients within 6.1 years (t(193) =  − 2.0, p = 0.047). GI-patients and GI-physicians agreed on the most important advantages of AI in healthcare: improving quality of care, time saving, and faster diagnostics and shorter waiting times. The most important disadvantage for GI-patients was the potential loss of personal contact, for GI-physicians this was insufficiently developed IT infrastructures. GI-patients and GI-physicians hold positive perspectives towards AI in healthcare. Patients were significantly more reserved compared to GI-fellows and GI-fellows were more reserved compared to gastroenterologists.
A solution for the rational dispatching of concrete transport vehicles
Authors: Guo Zhi-guang , Liu Yong-fu , Ao Chang-jiang
Published: October 2022

The amount of concrete needed in the construction of projects is enormous. The concrete dispatching in construction is, however, chaotic and causes grievous waste due to the tight construction schedule, heavy tasks, and improper transport vehicle dispatching by the constructor. This paper proposes a more realistic objective function in the vehicle dispatching algorithm and offers a solution to the rational dispatching of concrete transport vehicles. The analysis of the calculation example validates the feasibility of the built model, which provides more appropriate dispatching and more balanced distribution, meets the needs of the worksite and mixing station to the greatest extent and improves the level of project refinement and process management. Therefore, the model is worth promoting in future practice.
HTLV infection in Brazil’s second-largest indigenous reserve
Authors: Amianti Carolina , Bandeira Larissa Melo , Cesar Gabriela Alves , Weis-Torres Sabrina , Tanaka Tayana Serpa Ortiz , Machado Indianara Ramires , Gonçalves Crhistinne Cavalheiro Maymone , Simionatto Simone , Schnaufer Erica Cristina dos Santos , Freitas Felipe Bonfim , Vallinoto Antonio Carlos Rosário , Croda Julio , Motta-Castro Ana Rita Coimbra
Published: October 2022

Human T-lymphotropic viruses 1 and 2 (HTLV-1/2) have a worldwide distribution. HTLV-1 has been associated with several diseases, including an aggressive malignant disease known as adult T-cell leukemia/lymphoma and a chronic inflammatory neurological disease called HTLV-1-associated myelopathy, while HTLV-2 has not been definitively associated with diseases. HTLV-2 is most prevalent in specific groups such as injecting drug users and the indigenous population. In Brazil, most studies about HTLV in indigenous are carried out in indigenous communities from the north of the country. Mato Grosso do Sul (MS), Central Brazil, has the second-largest indigenous population in Brazil. However, there is no available data about HTLV infection in this group. We conducted the first investigation of HTLV-1/2 infection prevalence in the indigenous population from Jaguapiru and Bororó villages in Dourados City, MS, to provide the prevalence and molecular characterization of HTLV. For that, a total of 1875 indigenous participated in the study. All the serum samples were screened by an enzyme-linked immunosorbent assay commercial kit for the presence of anti-HTLV-1/2 antibodies. Positive samples were confirmed by HTLV-1/2 Western Blot assay. The HTLV-1 5’LTR region was detected by nested PCR amplification and sequenced by Sanger. Most of the study population declared belonging to Guarani-Kaiowá ethnicity (69.18%), 872 (46.51%), and 1003 (53.49%) were from Jaguapiru and Bororó villages, respectively. The median age of participants was 31 years, and 74.24% were females. Two individuals were detected with HTLV-1 (0.1%; CI 95% 0.1–0.2). The phylogenetic analysis revealed that isolates belong to the Cosmopolitan subtype and the Transcontinental subgroup (HTLV-1aA). The low HTLV-1 prevalence found in this study is similar to that observed among blood donors, and pregnant populations from Mato Grosso do Sul. The absence of HTLV-2 infection among these Brazilian indigenous communities would suggest a distinct behavior pattern from other indigenous populations in Brazil.
A post-trial follow-up study of pentosan polysulfate monotherapy on preventing recurrent urinary tract infection in women
Authors: Lee Yuan-Ju , Chang Shang-Jen , Lin Hsiu-Ying , Meng En , Chueh Jeff S. , Tseng Chi-Shin
Published: October 2022

For women with recurrent urinary tract infection (UTI), previous U101 study has shown that pentosan polysulfate sodium (PPS) monotherapy for 16 weeks significantly reduced UTI episodes in the treatment group throughout the trial period. In this follow-up study, we aimed to assess whether the effects of PPS would last after completion of the trial to prevent recurrent UTIs. Conducted from 2018 to 2019, the U101 study was a multicenter, prospective, phase 2a, randomized trial, enrolling women with recurrent UTI to study the effects of a 16-week oral PPS monotherapy. After approximately two years, the follow-up was conducted by phone interview, obtaining data including self-reported UTI events, quality of life questionnaire, and adverse events. The primary endpoint of follow-up study was UTI recurrence-free survival and the secondary endpoints were quality of life and adverse events. Approximately two years after completion of the trial, the rate of recurrent UTI was 25% (3 of the 12 patients) in the PPS group and 85.7% (12 of the 14 patients) in the control group. Over the entire follow-up period, the UTI recurrence-free survival was significantly better in the PPS group than in the control group (log-rank test p < 0.001). The quality of life at two years was significantly improved in the PPS when compared to the control group (91.7 vs. 77.5, p < 0.001). No late adverse event was observed after cessation of the treatment. In this study, sixteen weeks of PPS monotherapy in women with recurrent UTI significantly reduced the numbers of recurrent UTI episodes during the 2-year follow-up.
Time-dependent measurement of plasmon-induced charge separation on a gold nanoparticle/TiO2 interface by electrostatic force microscopy
Authors: Misaka Tomoki , Ohoyama Hiroshi , Matsumoto Takuya
Published: October 2022

Plasmon-induced charge separation (PICS) is an efficient way to use the hot carriers generated by localized surface plasmon resonance. Although the ultrafast dynamics of hot carrier generation and annihilation itself are well understood, the slow dynamics of PICS are not, despite their importance for the use of hot carriers in chemical reactions. In this work, we directly observed the slow dynamics of PICS on an Au nanoparticle (NP)/TiO2interface by using electrostatic force microscopy with time-resolved measurements obtained by sideband signal of frequency shift. The change in contact potential difference induced by PICS had a bias voltage dependence, indicating that the number of holes in the Au NPs ($$[{\mathrm{h}}_{\mathrm{AuNP}}^{+}]$$[hAuNP+]) accumulated by laser irradiation depended on bias voltage. The decay constant for the annihilation of the separated charge on the Au NPs at the Au NP/TiO2interface was directly determined to be ca. 150 ms, and the annihilation process was discussed in a simple model based on the transient Schottky barrier.
Fabrication of polyhedral Cu–Zn oxide nanoparticles by dealloying and anodic oxidation of German silver alloy for photoelectrochemical water splitting
Authors: Bahnasawy Nour , Elbanna Abdussalam M. , Ramadan Mohamed , Allam Nageh K.
Published: October 2022

A significant effort has been dedicated to the synthesis of Cu–Zn oxide nanoparticles as a robust photocathode material for photoelectrochemical water splitting. Cu–Zn oxide nanoparticles were formed by controlled anodization of German silver (Cu–Zn–Ni) alloy in an aqueous electrolyte. Scanning electron microscopy (SEM) demonstrates the dependence of the obtained nanostructures on the anodization time. The X-ray diffraction (XRD) patterns showed the formation of copper oxide (CuO) and zinc oxide (ZnO) nanoparticles with good stability. This was also confirmed by the compositional X-ray photoelectron spectroscopy (XPS) analysis. The obtained polyhedral nanoparticles showed high optical activity with adequate bandgap energy. These optimized nanoparticles achieved boosted photocurrent of − 0.55 mA/cm2 at − 0.6 V vs. SCE under AM 1.5 illumination, confirming the role of the optimized dealloying and thermal treatment in tuning the photoelectrochemical performance of the material.
Alteration of eggs biochemical composition and progeny survival by maternal high carbohydrate nutrition in a teleost fish
Authors: Callet Therese , Cardona Emilie , Turonnet Nicolas , Maunas Patrick , Larroquet Laurence , Surget Anne , Corraze Genevieve , Panserat Stephane , Marandel Lucie
Published: October 2022

Reproductive performances, and the factors affecting them, are of major importance especially for farmed fish in the context of the development of a sustainable aquaculture. Dietary maternal lipids have been identified as a major factor affecting reproductive performances. Nevertheless, the consequences of carbohydrates have been little studied while plant-derived carbohydrates could be increasingly used in broodstock diets. To explore this issue, 2-year-old female trout were fed either a control diet that contains no carbohydrate and a high protein content (65.7%) or a diet formulated with plant-derived carbohydrates containing 32.5% carbohydrate and 42.9% protein (’HC diet’) for an entire reproductive cycle. The reproductive performances, the quality of the unfertilized eggs and the development of the progeny were carefully monitored. Although the one year HC nutrition had not impaired female growth nor spawns quality, such nutrition had increased the variability of eggs size within spawns (+ 34.0%). Moreover, the eggs produced had a modified fatty acid profile, including a significant reduction in EPA content (− 22.9%) and a significant increase in the AA/EPA ratio (+ 33.3%). The progeny were impacted by such alterations as their survival rates were significantly reduced. A lower plant-derived carbohydrate inclusion (20%) should be considered in aquafeed for female broodstock in trout.
A novel vaccine based on SARS-CoV-2 CD4+ and CD8+ T cell conserved epitopes from variants Alpha to Omicron
Authors: Palatnik-de-Sousa Iam , Wallace Zachary S. , Cavalcante Stephany Christiny , Ribeiro Maria Paula Fonseca , Silva João Antônio Barbosa Martins , Cavalcante Rafael Ciro , Scheuermann Richard H. , Palatnik-de-Sousa Clarisa Beatriz
Published: October 2022

COVID-19 caused, as of September, 1rst, 2022, 599,825,400 confirmed cases, including 6,469,458 deaths. Currently used vaccines reduced severity and mortality but not virus transmission or reinfection by different strains. They are based on the Spike protein of the Wuhan reference virus, which although highly antigenic suffered many mutations in SARS-CoV-2 variants, escaping vaccine-generated immune responses. Multiepitope vaccines based on 100% conserved epitopes of multiple proteins of all SARS-CoV-2 variants, rather than a single highly mutating antigen, could offer more long-lasting protection. In this study, a multiepitope multivariant vaccine was designed using immunoinformatics and in silico approaches. It is composed of highly promiscuous and strong HLA binding CD4+ and CD8+ T cell epitopes of the S, M, N, E, ORF1ab, ORF 6 and ORF8 proteins. Based on the analysis of one genome per WHO clade, the epitopes were 100% conserved among the Wuhan-Hu1, Alpha, Beta, Gamma, Delta, Omicron, Mµ, Zeta, Lambda and R1 variants. An extended epitope-conservancy analysis performed using GISAID metadata of 3,630,666 SARS-CoV-2 genomes of these variants and the additional genomes of the Epsilon, Lota, Theta, Eta, Kappa and GH490 R clades, confirmed the high conservancy of the epitopes. All but one of the CD4 peptides showed a level of conservation greater than 97% among all genomes. All but one of the CD8 epitopes showed a level of conservation greater than 96% among all genomes, with the vast majority greater than 99%. A multiepitope and multivariant recombinant vaccine was designed and it was stable, mildly hydrophobic and non-toxic. The vaccine has good molecular docking with TLR4 and promoted, without adjuvant, strong B and Th1 memory immune responses and secretion of high levels of IL-2, IFN-γ, lower levels of IL-12, TGF-β and IL-10, and no IL-6. Experimental in vivo studies should validate the vaccine’s further use as preventive tool with cross-protective properties.
Improved remnant polarization of Zr-doped HfO2 ferroelectric film by CF4/O2 plasma passivation
Authors: Choi Yejoo , Park Hyeonjung , Han Changwoo , Min Jinhong , Shin Changhwan
Published: October 2022

In this work, the impact of fluorine (CF4) and oxygen (O2) plasma passivation on HfZrOx (HZO) based ferroelectric capacitor was investigated. By the fluorine passivation, the surface trap density and oxygen vacancies in the HZO-based Metal–ferroelectric–insulator–semiconductor (MFIS) capacitors were suppressed, resulting in the increased pristine remnant polarization (2Pr). The pristine value (2Pr) of baseline samples annealed at 500 °C and 600 °C were 11.4 µC/cm2 and 24.4 µC/cm2, respectively. However, with the F–passivation, the 2Pr values were increased to 30.8 µC/cm2 and 48.2 µC/cm2 for 500 °C and 600 °C, respectively. The amount of surface defects and oxygen vacancies are quantitatively confirmed by the conductance method and XPS analysis. However, due to the incorporation of fluorine atoms into the ferroelectric–insulator films, undesirable degradation on endurance characteristics were observed.
Factors associated with two different stroke mechanisms in perforator infarctions regarding the shape of arteries
Authors: Ha Sang Hee , Ryu Jae-Chan , Bae Jae-Han , Koo Sujin , Chang Jun Young , Kang Dong-Wha , Kwon Sun U. , Kim Jong S. , Chang Dae-il , Kim Bum Joon
Published: October 2022

Two different stroke mechanisms are involved in small vessel disease: branch atheromatous disease (BAD) and lipohyalinotic degeneration (LD). We compared mechanisms of stroke in lenticulostriate arteries (LSA) vs. anterior pontine arteries (APA) and verified factors associated with stroke mechanisms, including shape of middle cerebral artery (MCA) and basilar artery (BA). We retrospectively reviewed patients with acute ischemic stroke with penetrating artery territory confirmed by MRI. The mechanisms of stroke were categorized based on diffusion-weighted imaging; BAD was defined as lesion larger than 10 mm in LSA and lesions involving basal pontine in APA. Other lesions were classified as LD. The shapes of MCA and BA were classified as straight, with one angle, or with two angles (U, C or S shape, respectively) using anterior–posterior view. The study included 221 patients. LD was more common in LSA infarcts, but BAD was more common in APA infarcts (p < 0.001). Low initial National Institutes of Health Stroke Scale [Adjusted Odds ratio (aOR) = 0.78; p < 0.001], absence of hyperlipidemia [aOR = 0.31; p = 0.002], previous statin use [aOR = 4.35; p = 0.028] LSA infarcts [reference = APA territory; aOR = 11.07; p < 0.001], and S-shaped vessels (reference = straight shaped vessels; aOR = 3.51; p = 0.004) were independently associated with LD. Angulations in the mother vessels may be more associated with true small vessel disease more with LD than BAD.
Indigenous bacteria as an alternative for promoting recycled paper and cardboard mill wastewater treatment
Authors: Gholami Maryam , Ghaneian Mohammad Taghi , Teimouri Fahimeh , Ehrampoush Mohammad Hassan , Nadoushan Abbasali Jafari , Jambarsang sara , Mahvi Amir Hossein
Published: October 2022

The present study aimed to investigate indigenous bacteria possibility in recycled paper and cardboard mill (RPCM) wastewater treatment through the isolation and identification of full-scale RPCM indigenous bacteria. The molecular characterization of the isolated bacteria was performed by 16S rRNA gene sequencing. Klebsiella pneumoniae AT-1 (MZ599583), Citrobacter freundii AT-4 (OK178569), and Bacillus subtilis AT-5 (MZ323975) were dominant strains used for RPCM wastewater bioremediation experiments. Under optimal conditions, the maximum values of chemical oxygen demand (COD) and color biodegradation by C. freundii AT-4 were 79.54% and 43.81% after 10 days of incubation, respectively. In the case of B. subtilis strain AT-5 and K. pneumoniae AT-1, the maximum values of COD and color biodegradation were 70.08%, 45.96%, 71.26%, and 32.06%, respectively. The results from optimal conditions regarding efficiency were higher in comparison with the efficiency obtained from the oxidation ditch treatment unit in full-scale RPCM-WWTP. Therefore, the present study introduces the isolated indigenous bacteria strains as a promising candidate for improving the RPCM-WWTP efficiency using bioremediation.
Observation-based trajectory of future sea level for the coastal United States tracks near high-end model projections
Authors: Hamlington Benjamin D. , Chambers Don P. , Frederikse Thomas , Dangendorf Soenke , Fournier Severine , Buzzanga Brett , Nerem R. Steven
Published: October 2022

With its increasing record length and subsequent reduction in influence of shorter-term variability on measured trends, satellite altimeter measurements of sea level provide an opportunity to assess near-term sea level rise. Here, we use gridded measurements of sea level created from the network of satellite altimeters in tandem with tide gauge observations to produce observation-based trajectories of sea level rise along the coastlines of the United States from now until 2050. These trajectories are produced by extrapolating the altimeter-measured rate and acceleration from 1993 to 2020, with two separate approaches used to account for the potential impact of internal variability on the future estimates and associated ranges. The trajectories are used to generate estimates of sea level rise in 2050 and subsequent comparisons are made to model-based projections. It is found that observation-based trajectories of sea level from satellite altimetry are near or above the higher-end model projections contained in recent assessment reports, although ranges are still wide.
Feasibility and ethics of using data from the Scottish newborn blood spot archive for research
Authors: Cunningham-Burley Sarah , McCartney Daniel L. , Campbell Archie , Flaig Robin , Orange Clare E. L. , Porteous Carol , Aitken Mhairi , Mulholland Ciaran , Davidson Sara , McCafferty Selena M. , Murphy Lee , Wrobel Nicola , McCafferty Sarah , Wallace Karen , StClair David , Kerr Shona , Hayward Caroline , McIntosh Andrew M. , Sudlow Cathie , Marioni Riccardo E. , Pell Jill , Miedzybrodzka Zosia , Porteous David J.
Published: October 2022

Background

Newborn heel prick blood spots are routinely used to screen for inborn errors of metabolism and life-limiting inherited disorders. The potential value of secondary data from newborn blood spot archives merits ethical consideration and assessment of feasibility for public benefit. Early life exposures and behaviours set health trajectories in childhood and later life. The newborn blood spot is potentially well placed to create an unbiased and cost-effective population-level retrospective birth cohort study. Scotland has retained newborn blood spots for all children born since 1965, around 3 million in total. However, a moratorium on research access is currently in place, pending public consultation.

Methods

We conducted a Citizens’ Jury as a first step to explore whether research use of newborn blood spots was in the public interest. We also assessed the feasibility and value of extracting research data from dried blood spots for predictive medicine.

Results

Jurors delivered an agreed verdict that conditional research access to the newborn blood spots was in the public interest. The Chief Medical Officer for Scotland authorised restricted lifting of the current research moratorium to allow a feasibility study. Newborn blood spots from consented Generation Scotland volunteers were retrieved and their potential for both epidemiological and biological research demonstrated.

Conclusions

Through the Citizens’ Jury, we have begun to identify under what conditions, if any, should researchers in Scotland be granted access to the archive. Through the feasibility study, we have demonstrated the potential value of research access for health data science and predictive medicine.
Catalytic methoxylation of aryl halides using13C- and14C-labeled CO2
Authors: Ohleier Alexia , Sallustrau Antoine , Mouhsine Bouchaib , Caillé Fabien , Audisio Davide , Cantat Thibault
Published: October 2022

A late-stage carbon isotope strategy, which allows methoxylation from CO2, is reported. This catalytic process, that relies on the formation of BBN-OCH3, enabled13C and14C labeling of a series of substrates, including pharmaceuticals.
Polymer networks of imine-crosslinked metal–organic cages: tuneable viscoelasticity and iodine adsorption
Authors: Schneider Matthew L. , Campbell Jonathan A. , Slattery Ashley D. , Bloch Witold M.
Published: October 2022

The solution-state structure of MOP-15 is elucidated, enabling its direct use as a porous monomer for covalent polymer networks.
Metal phosphonates as heterogeneous catalysts for highly efficient chemical fixation of CO2 under mild conditions
Authors: Wang Yi-xin , Zhou Jing-hui , Xiong Jun , Huang Wan-qi , Li Quan , Min Xue , Li Ming
Published: October 2022

Two new compounds with novel structures were prepared, one of which displays excellent catalytic activity to transform CO2 gas to cyclic carbonates under mild conditions and free of solvent.
In-depth theoretical understanding of the chemical interaction of aromatic compounds with a gold nanoparticle
Authors: Tandiana Rika , Sicard-Roselli Cécile , Van-Oanh Nguyen-Thi , Steinmann Stephan , Clavaguéra Carine
Published: October 2022

The orientations of aromatic molecules at the surface of gold nanoparticles are probed and characterized by a combination of several topological analyses, energy decomposition analyses, and infrared spectroscopy.
Microscopic origin of diffusive dynamics in the context of transition path time distributions for protein folding and unfolding
Authors: Dutta Rajesh , Pollak Eli
Published: October 2022

Experimentally measured transition path time distributions should be analyzed theoretically in terms of a master equation with nearest neighbor jumps between microstates instead of a diffusion equation of motion over a free energy barrier.
Radiation effects, zero thermal expansion, and pressure-induced phase transition in CsMnCo(CN)6
Authors: Boström Hanna L. B. , Cairns Andrew B. , Chen Muzi , Daisenberger Dominik , Ridley Christopher J. , Funnell Nicholas P.
Published: October 2022

The Prussian blue analogue CsMnCo(CN)6 is studied by diffraction under variable temperature, pressure and X-ray exposure.
Geometries, interaction energies and bonding in [Po(H2O)n]4+ and [PoCln]4−n complexes
Authors: Zhutova Nadiya , Réal Florent , Vallet Valérie , Maurice Rémi
Published: October 2022

We report a study of hydrated and chlorinated Po(iv) complexes by means of gas-phase electronic structure calculations.
Release and migration of Pb from Pb(ii) and Pb(iv) compounds in the presence of microbiological activity
Authors: Gao Yaohuan , Trueman Benjamin F. , Li Bofu , Earle Martin R. , Gagnon Graham A.
Published: October 2022

Periodic detachment of biofilm or dynamics of biological activity may not be reflected by spikes in Pb release.
Anti-otomycotic potential of nanoparticles ofMoringa oleiferaleaf extract: an integratedin vitro,in silicoand phase 0 clinical study
Authors: Maher Zahran Eman , Mohamad Soad A. , Yahia Ramadan , Badawi Ahmed M. , Sayed Ahmed M. , Ramadan Abdelmohsen Usama
Published: October 2022

The work flow of the study.
One-pot conversion of engineered poplar into biochemicals and biofuels using biocompatible deep eutectic solvents
Authors: Kim Kwang Ho , Mottiar Yaseen , Jeong Keunhong , Tran Phuong Hoang Nguyen , Tran Ngoc Tuan , Zhuang Jingshun , Kim Chang Soo , Lee Hyunjoo , Gong Gyeongtaek , Ko Ja Kyong , Lee Sun-Mi , Kim So Young , Shin Ji Yeon , Jeong Hanseob , Song Hyun Kyu , Yoo Chang Geun , Kim Nak-Kyoon , Mansfield Shawn D.
Published: October 2022

Integrating plant cell wall engineering and process consolidation using biocompatible deep eutectic solvents could enable the development of sustainable biorefineries that effectively utilize both carbohydrates and lignin.
Photo-induced spatial gradient network for shape memory polymer with pattern-memorizing surface
Authors: Li Tiantian , Yan Shuzhen , Gao Xiaxin , Zhou Shuai , Li Jin , Ma Xiaodong , Yin Jie , Jiang Xuesong
Published: October 2022

A strategy of photo-induced gradient crosslinked network for SMP with patterned surface was developed. This non-uniform structure can achieve a complete pattern memory cycle from existence to elimination, and trigger the shape reconfigurations.
Nanostructure-induced L10-ordering of twinned single-crystals in CoPt ferromagnetic nanowires
Authors: Toyama Ryo , Kawachi Shiro , Yamaura Jun-ichi , Fujita Takeshi , Murakami Youichi , Hosono Hideo , Majima Yutaka
Published: October 2022

Nanostructure-induced L10-ordering of twinned single-crystals in CoPt ferromagnetic nanowires on Si/SiO2 substrates is demonstrated, where nanostructure-induced L10-ordering is driven by ultrasmall 10 nm-scale curvature radii of the nanowires.
Precise regulation of defect concentration in MOF and its influence on photocatalytic overall water splitting
Authors: Guo Changyan , Wang Tao , Zhang Li , Chen Tingxiang , Guo Cheng , Hassan Afaq , Akram Naeem , Kou Yuli , Wang Jide
Published: October 2022

The defective Cu-BDC photocatalysts with different defect concentration and Cu1+/Cu2+ coordinatively unsaturated sites (CUS) content were designed and synthesized by introducing defective linkers with different pKa values.
Intrinsic spin, valley and piezoelectric polarizations in room-temperature ferrovalley Janus TiXY (XY = SCl and SeBr) monolayers
Authors: Sheng Kang , Yuan Hong-Kuan , Zhang Bokai
Published: October 2022

Two-dimensional room-temperature Janus ferrovalley semiconductors with large spin, valley and piezoelectric polarizations provide fertile platforms for designing multifunctional nanodevices.
Interface engineering of hierarchical NiCoP/NiCoSx heterostructure arrays for efficient alkaline hydrogen evolution at large current density
Authors: Han Weiwei , Zhang Fan , Qiu Lingshu , Qian Yang , Hao Shaoyun , Li Ping , He Yi , Zhang Xingwang
Published: October 2022

Hierarchical NiCoP/NiCoSx heterostructure grown on Ni foam (NiCoP/NiCoSx/NF) exhibits outstanding electrocatalytic activity and stability for alkaline hydrogen evolution reaction under large current density.
TsCl-promoted thiolation of quinoline N-oxides with thiophenols
Authors: Hu Chengxian , Liu Ruikai , Ning Zhitao , Mou Dan , Fu Ying , Du Zhengyin
Published: October 2022

A metal- and oxidant-free method for the synthesis of various 2-thioquinolines through p-toluenesulfonyl chloride-promoted thiolation reaction of quinoline N-oxides with thiophenols in water at an ambient temperature is developed.
Microstructural origin of peculiar spectra and excellent luminescence properties of Y10Ta4O25:Eu3+ with a fluorite-related structure
Authors: Wei Donglei , Yang Xifeng , Liu Yushen , Seo Hyo Jin
Published: October 2022

Y10Ta4O25:Eu3+ presents peculiar spectra and excellent red luminescence properties due to its special fluorite-related structure. The microstructure was characterized by the site-selective luminescence of Eu3+ activators.
Plasma-assisted rhodium incorporation in nickel–iron sulfide nanosheets: enhanced catalytic activity and the Janus mechanism for overall water splitting
Authors: Li Junying , Wang Xiaodeng , Yi Lingya , Fang Changxiang , Li Tianhao , Sun Wei , Hu Weihua
Published: October 2022

Rh was incorporated in Fe-doped Ni3S2 nanosheets with the assistance of hydrogen plasma to significantly enhance the HER/OER catalytic activity. The operando evolution behavior and Janus catalytic mechanism of this catalyst were further revealed.
Recent developments in calix[4]pyrrole (C4P)-based supramolecular functional systems
Authors: Rather Ishfaq Ahmad , Ali Rashid , Ali Ayaaz
Published: October 2022

Recent advances with calix[4]pyrrole-based supramolecular functional entities in the fields of molecular recognition (receptors, sensors, and metal ion caged systems), self-assembly (polymers), photo/pH-responsive molecular switches and catalysis are reviewed.
Palladium catalyzed decarboxylative β-C-glycosylation of glycals with oxazol-5-(4H)-ones as acceptors
Authors: Ding Wei-Yi , Liu Huan-Huan , Cheng Jun Kee , Yao Hui , Xiang Shao-Hua , Tan Bin
Published: October 2022

Palladium catalyzed decarboxylative glycosylation of bicyclic glycals affords a series ofC-glycosylated oxazol-5-(4H)-ones with high efficiency and exquisite chemo- and stereoselectivity at the anomeric center under mild reaction conditions.
Iron-catalysed quinoline synthesis via acceptorless dehydrogenative coupling
Authors: Yu Ke , Chen Qianjin , Liu Weiping
Published: October 2022

An iron-catalysed atom-economical and straightforward methodology for the synthesis of quinolines from α-2-aminoaryl alcohols and secondary alcohols is presented.
Anisotropic hydrogel fabricated by controlled diffusion as a bio-scaffold for the regeneration of cartilage injury
Authors: Yu Xiaotian , Deng Zhantao , Li Han , Ma Yuanchen , Ma Xibo , Zheng Qiujian
Published: October 2022

Controlled fabrication of anisotropic materials has become a hotspot in biomaterials science, the next generation of tissue engineering is based on heterogeneous structures that can simulate the original biological complexity of the body.
Discovery of a monomeric green fluorescent protein sensor for chloride by structure-guided bioinformatics
Authors: Peng Weicheng , Maydew Caden C. , Kam Hiu , Lynd Jacob K. , Tutol Jasmine N. , Phelps Shelby M. , Abeyrathna Sameera , Meloni Gabriele , Dodani Sheel C.
Published: October 2022

We developed a workflow to identify and apply GFPxm163 as a new green fluorescent protein-based sensor for chloride.
Formal nucleophilic pyrrolylmethylationviapalladium-based auto-tandem catalysis: switchable regiodivergent synthesis and remote chirality transfer
Authors: Chen Zhi , Li Yu-Fan , Tan Shun-Zhong , Ouyang Qin , Chen Zhi-Chao , Du Wei , Chen Ying-Chun
Published: October 2022

A formal nucleophilic pyrrolylmethylation reaction was disclosedviaa palladium-catalysed tandem reaction between propargyl amines, allyl carbonates and aldimines. Switchable regiodivergent synthesis and chirality transfer could be well achieved.
Machine-learning-assisted prediction of long-term performance degradation on solid oxide fuel cell cathodes induced by chromium poisoning
Authors: Yang Kaichuang , Liu Jiapeng , Wang Yuhao , Shi Xiangcheng , Wang Jingle , Lu Qiyang , Ciucci Francesco , Yang Zhibin
Published: October 2022

We implement the machine-learning-assisted (MLA) method to predict the long-term stability of Solid Oxide Fuel Cell (SOFC) cathodes under the influence of Cr poisoning.
Fabrication of dual-functional electrochromic smart window based on low-cost hybrid transparent electrode coated with a solution-processable polymer
Authors: Cherumannil Karumuthil Subash , Ganesha Mukhesh K. , Mondal Indrajit , Singh Ashutosh K. , Kulkarni Giridhar U.
Published: October 2022

A cost-effective dual-functional polymeric electrochromic device using hybrid transparent electrodes promises to replace the traditional ITO-based smart windows in modern infrastructures and automobile industries.
Electric-field induced magnetic-anisotropy transformation to achieve spontaneous valley polarization
Authors: Guo San-Dong , Guo Xiao-Shu , Wang Guang-Zhao , Cheng Kai , Ang Yee-Sin
Published: October 2022

The electric field can induce an in-plane to out-of-plane transition of magnetic anisotropy, and then can produce spontaneous valley polarization.
Long-lived room temperature phosphorescence from amorphous non-traditional intrinsic clusteroluminescence polymers
Authors: Chen Kang , Wang Yaling , Chu Bo , Yan Zishan , Li Hairu , Zhang Haoke , Hu Shengliang , Yang Yongzhen , Liu Bin , Zhang Xing-Hong
Published: October 2022

The H-bond and ionic bond of the well-defined PSMA hydrolysates induce the TSI-n–π of carbonyl clusters to emit fluorescence and RTP.
Stimulus- and Person-Level Variables Influence Word Production and Response to Anomia Treatment for Individuals With Chronic Poststroke Aphasia
Authors: Braun Emily J. , Kiran Swathi
Published: October 2022

Purpose:

The impact of stimulus-level psycholinguistic variables and person-level semantic and phonological processing skills on treatment outcomes in individuals with aphasia requires further examination to inform clinical decision making in treatment prescription and stimuli selection. This study investigated the influence of stimulus-level psycholinguistic properties and person-level semantic and phonological processing skills on word production accuracy and treatment response.

Method:

This retrospective analysis included 35 individuals with chronic, poststroke aphasia, 30 of whom completed typicality-based semantic feature treatment. Mixed-effects logistic regression models were used to predict binary naming accuracy (a) at baseline and (b) over the course of treatment using stimulus-level psycholinguistic word properties and person-level semantic and phonological processing skills as predictors.

Results:

In baseline naming, words with less complex lexical–semantic and phonological properties showed greater predicted accuracy. There was also an interaction at baseline between stimulus-level lexical–semantic properties and person-level semantic processing skills in predicting baseline naming accuracy. With treatment, words that were more complex from a lexical–semantic standpoint (vs. less complex) and less complex from a phonological standpoint (vs. more complex) improved more. Individuals with greater baseline semantic and phonological processing skills showed a greater treatment response.

Conclusions:

This study suggests that future clinical research and clinical work should consider semantic and phonological properties of words in selecting stimuli for semantically based treatment. Furthermore, future clinical research should continue to evaluate baseline individual semantic and phonological profiles as predictors of response to semantically based treatment.

Supplemental Material:

https://doi.org/10.23641/asha.21256341
Fixed‐time fault‐tolerance attitude tracking control for spacecraft without unwinding
Authors: Huang Q. , Zhang Y.
Published: October 2022

In this paper, the attitude tracking control problem is investigated for rigid spacecraft subjected to external disturbance, inertia uncertainties, and actuator faults. The rotation matrix is used to model the spacecraft attitude control system which can get rid of the unwinding problem. A nonlinear observer is developed to achieve a high accuracy estimation for the lumped disturbance in fixedtime without the awareness of the boundary of disturbance. To restrain measurement noise, a tracking differentiator is used in the observer to construct signals instead of using the polluted measurement values. Based on the estimation provided by the disturbance observer, a fixed‐time attitude tracking controller is proposed by backstepping technique to stabilize attitude tracking errors in fixed time regardless of initial values. The singularity problem in traditional fixed‐time controllers based on signal function is eliminated with the help of the arctangent function in the proposed controller. The feature of the designed fixed‐time attitude controller is that it can suppress actuator faults, measurement noises and has no unwinding problem. Theoretical analysis based on Lyapunov theory and numerical simulations are presented to illustrate the robustness and effectiveness of the proposed control strategy.
A DC‐coupled 1.2 μW 0.012 mm2 per channel neural amplifiers array with 75 dB system common mode rejection ratio and 300 mV common mode interference
Authors: Wang Quan , You Changhua , Xue Ning , Zhang Xuan , Feng Chengcong , Zhao Zhengtuo , Yao Lei , Li Tie
Published: October 2022

System common mode rejection ratio (SCMRR) and common mode interference (CMI) range are two critical design specifications for multiple‐channel neural recording front‐end circuit in a freely moving animal experiment environment. This letter presents a neural amplifiers array consisting of 15 DC‐coupled inverter‐based recording channels, a reference channel and a shared voltage averaging circuit (VAC) with floating rail Common Mode Feedback (CMFB) to achieve high SCMRR and large CMI range. Meanwhile, power consumption and area are optimized through using simple inverter architecture and removal of the conventional on‐chip AC‐coupled capacitors. The proposed neural amplifier circuit is implemented in SMIC standard 0.18 μm CMOS process, achieving a typical 75 dB SCMRR (DC‐80 Hz), 300 mV CMI range, 1.2 μW power consumption and 0.012 mm2 area per channel. The circuit is validated both by bench‐top test and in‐vivo animal experiment.
Contribution of neural networks in image steganography, watermarking and encryption
Authors: Rafidison Maminiaina Alphonse , Rafanantenana Sabine Harisoa Jacques , Rakotomihamina Andry Harivony , Toky Rajaonarison Faniriharisoa Maxime , Ramafiarisona Hajasoa Malalatiana
Published: October 2022

In front of information fishing, it is necessary to protect the information to be circulated over public channel. The goal of this paper is to propose an approach which inserts a logo inside of cover image and having three different possible results according to user's needs. The algorithm can perform steganography, watermarking or host encryption. This technique is based on singular value decomposition (SVD) and discrete wavelet transform (DWT) composed by three steps: pre‐processing, embedding and extraction/decryption. Reference matrix and reference parameter are the two factors deciding the operation and the intervention of neural networks makes the choice of their parameters easier according to the desired result. For measuring the steganography performance, the authors adopt the structural similarity index measure (SSIM) which calculates the similarity between original and watermarked image and peak signal‐to‐noise ratio. For watermarking, the normalized correlation (NC) coefficient investigates the correlation between the original watermark and the extracted watermark. Attacking the watermarked image with common attacks used by previous publication searchers, the value of SSIM and NC coefficient are closed to one. Regarding peak signal‐to‐noise ratio, the overall score is around 61.73 dB. The performance score is not negligible also for the encryption method.
A hybrid high‐efficiency nine‐level inverter with high DC voltage utilization ratio
Authors: Ren Qicai , Chen Alian , Liu Xi , Liu Tong
Published: October 2022

This paper proposes a new hybrid nine‐level inverter topology with high efficiency and high dc voltage utilization ratio, which provides a potential for renewable energy power conversion. The proposed inverter can synthesize up to nine voltage levels with only ten switching devices and a flying capacitor (FC). To improve the operation efficiency, a hybrid‐device topology based on Si and SiC is proposed. The total device cost of this inverter is much lower than the all‐SiC‐based inverter. Compared with other advanced multilevel inverters, a notable feature is the more comprehensive performance of the proposed inverter. In addition to having fewer components and higher efficiency, the dc voltage utilization ratio of the inverter is 2.5 times that of the traditional inverter such as Neutral Point Clamped (NPC), FC, and Active NPC (ANPC). A hybrid FC voltage balancing strategy based on redundancy switching states and three voltage levels step switching method is implemented to reduce FC voltage ripple. Besides, a cooperative voltage control strategy between the dc‐link capacitors and FC ensures the neutral‐point voltage balancing. The voltage stresses analysis and the design guidelines of components are discussed in detail. A comparison with some existing topologies has also been made to highlight its performance. Experimental results verify the validity of the proposed inverter topology and the control schemes.
Assessment of expertise in morphological identification of mosquito species (Diptera, Culicidae) using photomicrographs
Authors: Rahola Nil , Günay Filiz , Öztürk Murat , Alten Bulent , Aqeehal Hanan A. , Saadawi Walid K. , Shaibi Taher , Kavran Mihaela , Petrić Dušan , Mitrović Jelena , Pajovic Igor , Velo Enkelejda , Kadriaj Përparim , Rogozi Elton , Jani Viola , Manucharyan Arsen , Paronyan Lusine , Sawalha Samer , M’ghirbi Youmna , Bouattour Ali , Rhim Adel , Ouni Ahmed , Samy Abdallah M. , Abozeid Shaimaa , Sarih M’hammed , Assaid Najlaa , Arich Soukaina , Sokolovska Nikolina , Janceska Elizabeta , Benallal Kamal Eddine , Haddad Nabil , Zakhia Renée , Muja-Bajraktari Nesade , Sherifi Kurtesh , Arbaji Majeda , Marić Jelena , Santrac Violeta , Dolidze Nato , Boussès Philippe , Deblauwe Isra , Schaffner Francis , Robert Vincent
Published: October 2022

Accurate identification of insect species is an indispensable and challenging requirement for every entomologist, particularly if the species is involved in disease outbreaks. The European MediLabSecure project designed an identification (ID) exercise available to any willing participant with the aim of assessing and improving knowledge in mosquito taxonomy. The exercise was based on high-definition photomicrographs of mosquitoes (26 adult females and 12 larvae) collected from the western Palaearctic. Sixty-five responses from Europe, North Africa and the Middle East were usable. The study demonstrated that the responders were better at identifying females (82% correct responses) than larvae (63%). When the responders reported that they were sure of the accuracy of their ID, the success rate of ID increased (92% for females and 88% for larvae). The top three tools used for ID were MosKeyTool (72% of responders), the ID key following Becker et al. [2010. Mosquitoes and their control, 2nd edn. Berlin: Springer] (38%), and the CD-ROM of Schaffner et al. [2001. Les moustiques d’Europe: logiciel d’identification et d’enseignement – The mosquitoes of Europe: an identification and training programme. Montpellier: IRD; EID] (32%), while other tools were used by less than 10% of responders. Responders reporting the identification of mosquitoes using the MosKeyTool were significantly better (80% correct responses) than non-MosKeyTool users (69%). Most responders (63%) used more than one ID tool. The feedback from responders in this study was positive, with the exercise being perceived as halfway between educational training and a fun quiz. It raised the importance of further expanding training in mosquito ID for better preparedness of mosquito surveillance and control programmes.
Metabolite Profiling of Talatisamine in Heart Tissue After Oral Administration and Analysis of Cardiac Bioactivities
Authors: Huang Shuai , Lv Yang , Wang Jian-Zhu , Ye Mei-Zhen , Lu Rui-Jie , Chen Lin , Xie Jiang , Gao Feng , Zhou Xian-Li
Published: October 2022

The lateral roots of the Aconitum carmichaelii (“Fuzi”) have been used for centuries as a cardiotonic in China. The diterpenoid alkaloid talatisamine (TA) is a major bioactive
component of Fuzi, but the identity and bioactivities of the TA metabolites have not been examined in detail. In this study, metabolite profiling of TA was performed in rat heart by UPLC-MS
following oral administration. Metabolites were identified by comparing protonated molecules, fragmentation patterns, and chromatographic behaviors with those of standard compounds.
Metabolites of TA were then prepared and tested for cardiotonic activity on isolated frog hearts. The metabolite cammaconine, a C19 diterpenoid alkaloid with a hydroxyl group at
C-18, exhibited substantial cardiotonic activity during frog heart perfusion. To further investigate the structure–cardiac effect relationships, a series of C19-diterpenoid
alkaloids with 18-OH were prepared. Eight tested compounds (5–12) demonstrated measurable cardioactivity, of which compound 5 with an N-methyl group and compound
7 with a methoxy at C-16 showed stronger effects on ventricular contraction than the other compounds. Thus, 18-OH is a critical structural feature determining cardiotonic activity,
and efficacy is improved by the presence of N-methyl or methoxy at C-16. Preliminary mechanistic studies suggested that the cardiotonic effect of compound 5 is mediated by
enhanced cellular calcium influx. Metabolites of TA with these structural features may be useful therapeutics to prevent heart failure.