bluuebunny/crossref_metadata_2025 huggingface dataset:
Primary indication for admissions to a multi-specialty paediatric intensive care unit in Sri Lanka
Authors: Vijayakanth V. , Dayasiri Kavinda , Thadchanamoorthy V. , Deshapriya U. G. S. , Gamage P. P. H.
Published: January 2024

It is critical to analyse the pattern of admissions made to a multi-specialty ICU (Intensive Care Unit) facility in order to enhance the standard of care, update resources, and to train the PICU (Paediatric Intensive Care Unit) personnel. Policymakers, funders, healthcare practitioners and administrators must be aware of the epidemiology and patterns of ICU admissions improve existing health services and plan for future delivery of intensive care.Objectives was to describe the primary indication for admissions to a multi-specialty Paediatric Intensive Care Unit of Teaching Hospital, Karapitiya, Sri Lanka. Children from birth to 16 years of age treated in the PICU from 1st April 2022 to 31st March, 2023 were retrospectively analysed. Information was collected on age, sex, home town, mode of admission, primary specialty indication, length of stay, main system involved, requirement of mechanical ventilation and survival.A total of 341 children were admitted and were included in the study. 60.5 % of the study population were males. Transfers within hospitals (62.1%) outnumbered transfers outside hospitals (37.9%).The average PICU stay was 5.8 days. Respiratory illnesses accounted for 54.4% of medical admissions and was the most common reason for intensive medical care. Other indications included neurological problems (21.3%) and multiorgan sepsis (8.4%). Leading cause of surgical specialty admissions was post-operative care (80.8%). Overall survival rate was 87.9% and mortality rate was 12.1%.Respiratory and neurological problems and multi-organ sepsis were the most common reasons for medical admission to the PICU. Leading cause of surgical specialty admissions was post-operative care. Overall survival rate was 87.9%.
Fiestas religiosas y migraciones: virgen de Caacupé en González Catán
Authors: Melella Cecilia , Matossian Brenda
Published: January 2024

Este artículo analiza la festividad religiosa de la Virgen de Caacupé en el Club Atlético Deportivo Paraguayo de La Matanza (Región Metropolitana de Buenos Aires, Argentina) como una práctica social, cultural y espacial vinculada a dicha comunidad. La Matanza es un municipio con una alta concentración de población paraguaya; así, la relación entre las celebraciones y la apropiación de espacio urbano confluye por su interés y dinámica. Desde una mirada comunicacional y geográfica, el estudio de la festividad permite comprender percepciones, tensiones y silencios entre los principales actores de la comunidad migrante, del barrio y del municipio, así como las estrategias migratorias y modos de territorialización que se ponen en juego.
Clinicopathological correlation of insulin-like growth factor binding protein 3 and their death receptor in patients with gastric cancer
Authors: Ansari Amir , Gheysarzadeh Ali , Sharifi Ali , Mofid Mohammad Reza
Published: January 2024

Background and purpose:

The insulin-like growth factor binding protein 3 (IGFBP-3) and its novel death receptor (IGFBP-3R) have been exhibited to have tumor suppressor effects. Despite their prognostic value in some cancers, they have not been elucidated in gastric cancer.

Experimental approach:

We collected 68 samples from patients with gastric cancer. IGFBP-3 and IGFBP-3R expression levels were evaluated with quantitative real-time polymerase chain reaction (RT-PCR) and western blotting in patients. The relationship between prognostic factors and IGFBP-3/IGFBP-3R expression was also evaluated.

Findings/Results:

Our results showed that IGFBP-3 and IGFBP-3R expression was reduced significantly in tumor tissues. We found that there was an association between the reduction of IGFBP-3 with lymph node metastasis and tumor-node-metastasis (TNM) staging. Besides, IGFBP-3R expression was associated with tumor size, lymph node metastasis, differentiation, and TNM classification. Interestingly, we presented that the downregulation of IGFBP-3R was stage-dependent. In survival analysis, our findings showed that low levels of IGFBP-3R mRNA expression exhibited a close correlation with survival rate.

Conclusion and implications:

The findings of this study showed that the expression levels of IGFBP-3 and IGFBP-3R are valuable prognostic factors. Despite the potential of IGFBP-3, IGFBP-3R plays a significant role as a prognostic factor in gastric cancer. However, these findings need to be developed and confirmed by further studies.
Oral Manifestations, Risk Factors and Management Strategies of COVID-19 Associated Mucormycosis in Tertiary Care Hospital
Authors: Goel Pankaj , Kumar Jitendra , Rai Anshul , Shakti Prateek , Chouksey Gunjan
Published: January 2024

Background:

Mucormycosis (black fungus) is an aggressive, life-threatening infectious disease-causing infiltration and by destroying the surrounding bone and soft tissue through vascular thrombosis and subsequent tissue infarction that may reach the brain with fatal complications. Its outbreak has been assessed around the clock during the recent pandemic as post COVID-19 sequelae.

Aims:

To assess the risk factors, oral signs and symptoms, investigations, treatment and rehabilitation strategies amongst COVID-19 associated mucormycosis patients in a tertiary care hospital.

Methods and Material:

An observational, pilot study was carried out amongst 30 active or recent COVID-19 associated mucormycosis patients reporting in the Department of Dentistry of a tertiary care hospital in Bhopal over a period of 6 months. Statistical analysis was done using Kolmogorov-Smirnov test using the Statistical Package for Social Sciences, Version 16 software.

Results:

Study was done on 30 patients (80% males and 20% females) and their median age was 46 years. Predominant risk factor present was diabetes mellitus (90%) and steroid therapy (60%). Prime oral manifestations were toothache (90%), mobile teeth (83%), draining sinus (53%), palatal ulceration (43%) and para-sinusal pain (37%).

Conclusions:

Mucormycosis can cause serious oro-facial morbidity and mortality in COVID-19 patients. The current management strategy requires early diagnosis, prompt treatment and oral rehabilitation.
Increased Vitamin B12 Levels in Patients with Oral Cancer
Authors: Gupta Prashant , Chandra Subhash , Jha Awanindra Kumar , Khaitan Tanya , Shukla Anjani Kumar , Naik Shantala R
Published: January 2024

Background:

Oral cancer (OC), which happens to be one of the leading causes of death in the Indian population, is caused primarily by tobacco use, although other factors are also responsible. Serum vitamin B12 is important in maintaining the immune system and also repairing the damaged deoxyribonucleic acid (DNA) of cells. The aim of our study was to evaluate the serum B12 levels in patients with OC and look for any association between the two.

Methods:

One hundred subjects were selected for the study and divided into two groups: group A having OC (including cases of oral squamous cell carcinoma (OSCC), verrucous carcinoma and oropharyngeal carcinoma; 50 patients) and group B had age- and gender-matched healthy controls (50 healthy volunteers). Patients diagnosed clinically and histopathologically confirmed as OC were selected for the study. All the patients were subjected to haematological investigation to assess serum vitamin B12.

Results:

Males subjects in the 4th and 5th decades of life were predominantly affected. Serum vitamin B12 was significantly increased in OC patients when compared with controls, which was statistically significant. The mean serum vitamin B12 was slightly higher in males than in females, which was statistically non-significant.

Conclusion:

Our study found increased vitamin B12 levels in OC patients, and it was statistically significant.
Relationship between Skeletal Maturity Indicators and Dental Calcification Stages in a Sample Pediatric Population
Authors: Ojha Akshaya , Chawla Riddhi , Sihag Tarun , Ahmed Ameena , Qurishi Ahtesham A. , Rajkumari Laleena
Published: January 2024

Context:

Human growth shows considerable variation. In addition to constitutional differences in the timing of maturation, there are diseases, systemic disorders and environmental factors that may affect a child's physiologic maturity. Interrelationships among skeletal, somatic and sexual maturity have been shown to be consistently strong. The study was conducted to evaluate the relationship between dental calcification stages and skeletal maturity indicators.

Materials and Methods:

The hand wrist radiographs, the lateral cephalogram and the orthopantomogram (OPG) of 120 patients (60 males and 60 females, age group 8–14 years) were taken. The hand wrist radiographs were analyzed using Fishman's skeletal maturity index (SMI), and the cephalograms analyzed by cervical vertebrae maturation (CVM) by Baccetti. OPG was analyzed according to the Demirjian's system.

Result:

On assessment, cervical vertebrae maturation indicator (CVMI) staging showed significant results with a correlation coefficient of 0.716 being the highest in canines in males while assessment of dental calcification stages and its comparison with skeletal maturity indicator showed insignificant results. The correlation coefficient values were 0.11, 0.09, 0.09 and 0.13 for canine, first premolar, second premolar and second molar respectively.

Conclusion:

There is a strong correlation between the maturation stage of cervical vertebrae and calcification stages of canine, first premolar, second premolar and second molar as determined by Demirjian's method.
Presence of Heavy Metals in over the Counter Teeth Whitening Products– An Evaluative Study
Authors: Ravi Chitra , Muthappan Sendhilkumar , Ponnaiah Manickam , Chandrasekaran Deepika , Murugavel Sowmiya , Samson Jimson
Published: January 2024

Background:

Dentistry plays a crucial role in shaping the facial aesthetics of a person and thus boosts self-esteem. Tooth discolouration is one of the significant cosmetic problems and hence, many teeth whitening products are widely used for discolouration. However, these products may have heavy metals or chemicals that can affect the tooth and other organs.

Aim:

The aim is to estimate the amount of heavy metals present in teeth whitening products available for purchase over-the-counter in the pharmacies.

Materials and Method:

A cross-sectional study of teeth whitening products available Over the Counter (OTC) in pharmacies in Chennai and adjoining districts of Tamil Nadu was conducted during the period from December 2019 to February 2020. The Flame Atomic Absorption Spectrometry (FAAS) method was used to measure the heavy metals such as inorganic lead, chromium, cobalt, arsenic, cadmium, nickel and mercury in the products.

Results:

We collected 39 products and finalized nine for analysis. These products were available as tablet (n = 1), liquids (n = 2) and powders (n = 6). All products were mentioned as herbal or natural. Three products contained inorganic lead levels in parts per million (ppm) of 759 (product 2); 39.4 (product 3) and 28.1 (product 7), way above the permitted levels. None of the other heavy metals were detected from these products.

Conclusion:

After analysis with the FAAS method, inorganic lead over and above the permissible levels was observed. Dental professionals and community need to be aware of the availability of such products and its detrimental effects on oral and general health.
A Case Report of Angiosarcoma of the Tongue: A Diagnostic Dilemma at Presentation
Authors: Bhattacharya Shilajit , Koshy Ajit V. , Baldawa Prachi , Thakur Samantha , Shah Amisha , Bhagwat Harshad
Published: January 2024

Rationale:

Angiosarcoma is a malignant mesenchymal tumor arising from vascular endothelial cells. This is an aggressive malignancy associated with poor prognosis. Angiosarcoma in the head and neck is exceedingly rare, accounting for less than 4 % of tumors.[1]

Patient Concern:

We report a unique case of angiosarcoma involving the tongue underlying the diagnostic conundrum and pointers towards an accurate diagnosis.

Take-away lesson:

Due to rarity of the disease, consensus on optimal treatment approach is lacking and multicenter prospective studies would be helpful to set clinical guidelines.
Random Tree Algorithm to Analyse the Relation between Type of Traumatic Dental Injuries and Its Demographic and Predisposing Factors - A Cross-Sectional Study
Authors: Khan Mohammad Kamran , Jindal Mahendra Kumar
Published: January 2024

Background and Aim:

Traumatic dental injuries (TDIs) have become the public dental health problem worldwide in children and adolescents. These injuries are complex and multifactorial in aetiology. This study was done with the aim to analyse the association of 'type of TDI' with its demographic and various predisposing factors in children by an advanced statistical method of machine learning (ML) of artificial intelligence (AI).

Materials and Methods:

The present study's data were gathered by conducting the observational cross-sectional study among index age-groups 12 and 15 years children of randomly selected schools of different geographical regions. Structured interviews and dental examinations performed were done to record the variables of TDIs in self-constructed proforma. The gathered data were analysed by employing the random-tree model of machine learning algorithm of IBM SPSS Modeler version-18 software.

Results:

Molar-relationship (2.5), age (1.75), sex (1.5) and geographical region/area (~1.5) were the most important predictors (factors) for the determination of type of dental injury as shown by the random tree model, whereas clinical factors like overjet (0.75), lip-competence (0.5) and overbite (0.5) showed lesser importance in the determination of type of TDIs.

Conclusion:

Demographic factors (age, sex and geographical region) and one clinical factor (molar-relation) were found as the stronger factors for determining the type of traumatic dental injury in children.
Effectiveness of rotator cuff and scapular strengthening exercises with low-level laser therapy on pain, range of motion, strength, and functional abilities in a patient with partial supraspinatus tear: A case report
Authors: Shetty Shruti Dhananjay , Prem Chaithanya , Sreejisha P. K.
Published: January 2024

One of the most prevalent musculoskeletal problems is rotator cuff (RC) injury. The most frequent RC injury is a supraspinatus tear. A partial supraspinatus tear is a partial tear or rupture of the tendon of the supraspinatus muscle and usually presents with pain, weakness, and difficulty in raising affected arm. The aim of this study is to determine the effectiveness of RC and scapular strengthening exercises with low-level laser therapy on pain, range of motion (ROM), strength, and functional abilities of a 61-year-old patient presenting with partial supraspinatus tear. The treatment was given for 5 days/week for 6 weeks. Pain, ROM, strength, and functional abilities were assessed by the Shoulder Pain and Disability Index, goniometer, and handheld dynamometer. Interventions are found to be effective in improving pain, ROM, strength, and functional abilities in patient with partial supraspinatus tear.
Profile of hospitalised maltreated children aged 0 to 3 years and their families
Authors: Kwan Rui , Abraham Sharon , Low Wilson Cong Jin , Lim Jasmine Chiew Yi , Chong Wan Har , Mun Sylvia Bee Suan , Oh Jean Yin , Chay Oh Moh , Yeleswarapu Sita Padmini
Published: January 2024

Introduction:

Maltreatment adversely affects children’s health and development. Knowledge of child maltreatment in early childhood is limited. We studied the demographic factors and health issues in children aged 0–3 years who were hospitalised for maltreatment.

Methods:

In this retrospective cohort study, health and demographic information was extracted from the electronic medical records of children hospitalised in KK Women’s and Children’s Hospital between January 2018 and June 2019. High-risk groups were children with developmental delay (DD), missed vaccination (MV), low outpatient attendance, high dependency unit (HDU) or intensive care unit (ICU) admission and Child Protection Service (CPS) referral. Chi-square or Fisher’s exact test was used for categorical variables. Mann–Whitney U test was used for skewed quantitative variables.

Results:

Among the 101 children included in the study, the most common type of abuse and alleged perpetrator were physical abuse and parents, respectively. In addition, 35.6% of the children had pre-existing health conditions before hospitalisation, 58.4% had new health conditions diagnosed during hospitalisation requiring follow-up and 26.7% had maltreatment-related injuries. One-fifth of the children had DDs and another one-fifth had MVs. About 20% of them had defaulted all outpatient appointments. High-risk children mostly lived in rented housing. Their mothers mostly had primary education or lower. Most children admitted to ICU or HDU were <6 months old (8/12 [66.7%] vs. 6–24 months 3/12 [25%] vs. 24–47 months 1/12 [8.3%], P = 0.001). A higher number of children with DD were referred to CPS (63.2%, P = 0.049) than to other agencies.

Conclusion:

Maltreated children have significant health needs that are not fully met through routine surveillance practices. They are at risk of defaulting their hospital appointment. It is imperative that families at risk of child maltreatment are identified early and their needs holistically evaluated, with care coordinated within the hospital–community support system.
Facultad del acreedor personal del socio insolvente o del empresario individual para solicitar la disolución de una sociedad de personas o de una empresa individual de responsabilidad limitada
Authors: Manterola Domínguez Pablo
Published: January 2024

Este artículo busca establecer si el acreedor personal del socio de una sociedad de personas, y también del titular de una empresa individual de responsabilidad limitada, puede pedir su disolución por insolvencia de su deudor, para así mejorar la capacidad patrimonial de este con la cuota de liquidación. El trabajo atiende a la historia fidedigna de los preceptos del Código Civil aplicables a la materia, así como al sentido de las disposiciones, tanto en el contexto de la sociedad colectiva como en el de la sociedad de responsabilidad limitada y en el de la empresa individual de responsabilidad limitada. Dado que la interpretación debe efectuarse conforme con el tipo social, y que su resultado debe equilibrar los intereses de acreedores sociales o empresariales y personales de los socios o del titular, se concluye que en las sociedades colectivas y en las empresas individuales los acreedores personales del socio o titular insolvente pueden demandar la disolución de la sociedad o la terminación de la empresa, mientras que los acreedores personales del socio de una sociedad de responsabilidad limitada no pueden hacerlo, porque ello importaría una ruptura del equilibrio entre los dos grupos de acreedores.
Phase Angle as a Nutritional Assessment Method in Patients with Hip Fractures: A Cross-Sectional Study
Authors: Kubo Yuta , Noritake Kento , Noguchi Taiji , Hayashi Takahiro
Published: January 2024

Background: Phase angle, which is associated with cellular health, has attracted attention as a noninvasive and objective method for nutritional assessment. However, the association between malnutrition and phase angle in older inpatients with hip fractures has not been reported. Therefore, this study investigated this association in older inpatients (aged ≥65 years) with hip fractures and determined the cutoff phase angle for determining malnutrition.Methods: This cross-sectional study retrospectively analyzed the data of 96 inpatients with hip fractures who were hospitalized in rehabilitation units after surgery (male, 29.4%; mean age, 82.4±6.2 years). Nutritional status was assessed using the Geriatric Nutritional Risk Index (GNRI), with malnutrition defined as a GNRI ≥98. Bioelectrical impedance analysis was used to measure phase angles. Results: The phase angle was associated with malnutrition (B=−1.173; odds ratio=0.310; 95% confidence interval 0.58–0.83; p=0.015). The area under the receiver operating characteristic curve was 0.71. The cutoff phase angle for malnutrition was 3.96° (sensitivity=0.85, specificity=0.63). Conclusion: Phase angle could be an indicator of malnutrition in older inpatients with hip fractures. Our findings will help formulate rehabilitation strategies for these patients.
Mass Drug Administration: Contextual Factor Considerations
Authors: Schneider Zachary D. , Busbee Alexandra L. , Boily Marisa C. , Shah Monica P. , Hwang Jimee , Lindblade Kim A. , Gutman Julie R.
Published: January 2024

In designing mass drug administration (MDA) campaigns, it is imperative to consider contextual factors that affect uptake of the intervention, including acceptability, cost, feasibility, and health system considerations, to ensure optimal coverage. We reviewed the literature on contextual factors influencing MDA delivery to provide programs with information to design a successful campaign. From 1,044 articles screened, 37 included contextual factors relevant to participants’ values and preferences, drivers of MDA acceptability, health equity concerns, financial and economic aspects, and feasibility barriers; 13 included relevant modeling data. Key findings were abstracted by two reviewers and summarized. No studies directly assessed values or direct health equity concerns with respect to MDA, which represents an evidence gap as unequal distributions of effects and factors that impact participant acceptability and program feasibility must be considered to ensure equitable access. Participant acceptability was the most widely surveyed factor, appearing in 28 of 37 studies; perceived adverse events were a frequently noted cause of nonparticipation, mentioned in 15 studies. Feasibility considerations included when, where, and how drugs will be delivered and how to address pregnant women, as these can all have substantial implications for participation. Mass drug administration costs (∼$1.04 to $19.40 per person per round) are driven primarily by drug prices, but the delivery mechanism can have varying costs as well, and integration with other interventions may provide cost savings. Both programmatic goals and sociopolitical and economic contexts must be carefully considered before embarking on an MDA program to ensure programmatic success.
Phytochemical composition and insecticidal effects of native plant extracts against the mango mealybug, Rastrococcus invadens Williams (Homoptera: Pseudococcidae)
Authors: Mano Elias , Sanou Désiré Dramane Abdoul Khader , Sawadogo Alizèta , Ouédraogo Rasmané Abdou , Sidibé Abdoulaye , Boubakar Ouattara , Sombié Pierre Alexandre Eric Djifaby , Dabiré Anogmain Rémy , Sankara Fernand , Nacro Souleymane
Published: January 2024

The mango mealybug Rastrococcus invadens Williams causes enormous damage to fruit trees in Burkina Faso, with losses of up to 90% for mango trees and 53% for citrus fruits. The objective of this study was to evaluate the insecticidal effects of native plant extracts against this insect pest. The insecticidal activity and biological effectiveness of the extracts were evaluated on Petri dishes and mango leaves previously contaminated by spraying them with the native plant extracts. The experimental was a completely randomized Fischer block, and compared six doses of the hydroalcoholic extracts of A. conyzoides and H. suaveolens with abamectin 18 EC and water (control). These treatments were repeated up to ten times. The determination of the efficiency coefficients was achieved using Abbott's formula (1925). Both extracts of A. conyzoides and H. suaveolens were effective, but the one based on A. conyzoides at 50 gl -1 was the most effective with 100% mortality in 48 hours compared to 95.00% for H. suaveolens’ extract in 72 h. Their respective LC50 were 12.50 gl -1 and 17.49 gl -1, showing that A. conyzoides’ extract is more toxic to R. invadens. The high content in phenols, flavonoids, alkaloids, etc. of leafy stems of A. conyzoides and of H. suaveolens could help to sustainably control R. invadens in an integrated approach and effectively protect mango orchards.
Aktualisasi Karakter Kristus Menurut Philip Yancey Bagi Pendidikan Iman Kristen
Authors: Nggebu Sostenis , Mardiani Ridha
Published: January 2024

The problem of this article is discussing the importance of Philip Yancey's Christological views applied in efforts to educate Christians in their faith which is centred on Christ. The purpose of this article is to explain Yancey's thoughts about the figure of Jesus who changes the lives of believers to become like Him. The method used is literature study. The results show that Yancey's thoughts about the characteristics of Jesus were not to stimulate objective academic-dogmatic thinking, but rather to present personal reflections as a journalist in order to reveal the identity of the Nazarene Youth through the literature he wrote. The Jesus he knew was a figure who changed him and would also change every person who met personally with the Son of God. Yancey tries to develop a new synthesis regarding the character and profile of Jesus and encourages readers to welcome Jesus as the authority over human life. Yancey's ideas about the figure of Jesus can be used as material for Christian faith education for the maturation of believers' faith. In conclusion, people who know and believe in Jesus personally are guaranteed to experience renewal of life and become like Him.
A CLINICAL STUDY TO EVALUATE THE EFFECT OF NAGARADI KWATHA AND
CHANDRAPRABHA VATI IN MOOTRASHMARI W.S.R. TO UROLITHIASIS
Authors: Nivas Ram , v Prashanth
Published: January 2024

Ashmari is the formation of stone in Mootravaha srotas, resulting in severe pain as given by the enemy. It is an
effect of the complex, physicochemical process that involves a sequence of events in the formation of any urinary
stones, including urinary saturation, supersaturation, nucleation and growth of crystals, aggregation and retention
of crystals, and finally, stone formation. It affects about 12% of the world's population at some stage in their lifetime in all age groups, sexes, and races but occurs more frequently in men than women aged 20 to 49 years. In
India, about 12% of the total population is expected to have urinary stones in their life, out of which 50% may end
up with loss of kidney function. Contemporary treatment such as Lithotripsy (ESWL), Percutaneous Nephrolithotomy (PCNL), Retrograde Intra-renal surgery (RIRS), and Laparoscopic Ureter lithotomy adopted in the condition of Urolithiasis is quite costly with high incidence of recurrence. For the present study, Nagaradi Kwatha
and Chandraprabha Vati were administered for 14 days. Each patient was observed on the 0-day, 7th, and 15th day
of drug intervention with said parameters. The study showed significant clinical improvement in reducing the
shoola, mootradosha, Kruchramutrata, and Sarakta mootrata and showed good response in disintegration and the
expulsion of Ashmari.
Comparison of the use of Metyrapone and Osilodrostat for Cushing Disease: A Systemic Review
Authors: K Manikanda Prabhu , S Kishore , S Mohamed Akram Ali , H Rajamohamed , R Nepolean
Published: January 2024

Introduction: Cushing disease is characterised by excessive production of adrenocorticotropic hormone (ACTH) from the anterior pituitary, which results in increased release of cortisol from the adrenal glands. Nearly 10 to 15 million people per year have been reported to have this rare disease. As of today, there are different therapies available. The chances of recurrence and severe side effects are high. Objectives: To overcome the recurrence and side effects, we compared the drugs metyrapone and osilodrostat (class 11 beta-hydroxylase inhibitors) for their safety, efficacy, and other pharmacological actions before Cushing's disease. Methodology: Nine electronic databases were searched regarding the drugs metyrapone and osilodrostat for the treatment of Cushing's disease using the keywords. A total of 14 case studies were collected, which show different results and conclusions. Results and discussion: Based on the comparison, both drugs exhibited the same mechanism of action, but administering metyrapone showed more severe side effects than osilodrostat. While osilodrostat has greater efficacy, reducing the cortisol level faster, and also, the drug osilodrostat has a prolonged half-life, allowing it to be used only twice daily compared to the drug metyrapone, which requires six times daily dosing. Conclusion: Based on this, we conclude that the drug osilodrostat has a greater advantage over the drug metyrapone and is also the best treatment option for Cushing's disease.
El derecho a la intimidad o privacidad como derecho humano
Authors: Monroy Ramírez María Carolina
Published: January 2024

PROBLEMA: en la actualidad, principalmente en Guatemala no se cuenta con una normativa legal que estipule la violación al derecho de la intimidad ya que al hacerlo se estaría violando el derecho humano. OBJETIVO: determinar un estudio analítico del derecho a la intimidad o privacidad como derecho humano, para establecer si existe una normativa legal que lo ampare. MÉTODO: mediante la investigación se utilizó la lectura de libros, así como normativas legales, para esclarecer todo lo relevante al derecho a la intimidad o privacidad como derecho humano. RESULTADOS: las personas que se sienten vulneradas en su intimidad o privacidad tienen el derecho a exigir que se le proteja. La legislación guatemalteca establece uno de los derechos fundamentales como es la vida, también se considera que el derecho a la intimidad o privacidad es parte fundamental de la vida y no deben ser vulnerados, pues hoy en día el derecho a la intimidad se ve violado y mucho radica en que, en Guatemala, no está establecido dicho derecho, sino que se presta a que la privacidad pueda llegar a ser publica sin el consentimiento de las personas. CONCLUSIÓN: es necesario que los habitantes tengan la certeza que sus derechos se encuentren bien establecidos y la información solicitada sea entregada por la persona afectada; para que solamente con su autorización se pueda hacer uso de ella.
La gobernanza en la transformación digital
Authors: Pérez Palma Wendy Johana
Published: January 2024

PROBLEMA:  la gobernanza y la gobernabilidad son conceptos que han tendido a confundirse y la implementación de tecnologías no se ha aprovechado lo que debería de implementarse para impulsar la transparencia de los gobiernos. OBJETIVO:  establecer los efectos que ha tenido la gobernanza en la era digital. De igual forma se centra en una investigación de conceptos tales como el gobierno digital que busca la simplificación de los servicios prestados a los individuos, implementación de estos y la situación actual de la estrategia para mejorar y volver más factible un gobierno electrónico en Guatemala. MÉTODO:  recolección y el análisis de datos cualitativos. RESULTADOS: los principales hallazgos fueron que es necesario encajar dentro de las variables principales y secundarias para poder determinar el porcentaje de éxito que tendrá la gobernanza utilizando los medios digitales que tienen a su disposición. CONCLUSIÓN: la transformación digital es inevitable y está sucediendo por lo tanto no sólo las políticas actuales deben ir dirigidas a esta tendencia sino más bien es un conjunto que conlleva el respaldo financiero y el recurso humano como factor determinante de su éxito.
El movimiento sublunar
Authors: Ramirez Flores Mario Antonio , Santos Caballero Manuel Galileo
Published: January 2024

Existen distintas formas de resolver problemas de movimiento, a saber, de manera newtoniana, lagrangiana, hamiltoniana, métodos poderosos en la solución de cualquier problema relativo al movimiento y sus posibles causas. En el caso actual se presenta el empleo de la Variable Compleja que resulta ser otro planteamiento para la solución de problemas de aplicación, ergo, muestra otra forma en el procedimiento para resolver problemas de la mecánica. Las aplicaciones de la variable compleja son de gran envergadura en diferentes áreas de la ingeniería. En este artículo se analiza el problema de la órbita de un satélite artificial alrededor de la tierra, cuya solución involucra la definición de números complejos, y a partir de él, se llega a los conceptos de velocidad y aceleración complejas, para con ellos establecer las ecuaciones complejas para la descripción del movimiento.
Modelado numérico de un elastómero (NBR) sometido a carga axial
Authors: Zuñiga-Cid Ivan , Coutiño-Moreno Elvis , Estrada-Barbosa Quirino , Soto-Mendoza Gilberto
Published: January 2024

Actualmente el mercado de la manufactura de productos exige la mejora de los materiales con menor costo y una mayor calidad. El presente trabajo se realizó en una empresa de giro automotriz en México donde se manufacturan mangueras hidráulicas de alta presión, esta empresa busca innovar los materiales para poder competir contra otras marcas. Realizar productos con nuevos materiales implica realizar pruebas experimentales que implican tiempo y costo. Con este proyecto se buscó reducir el tiempo y el costo de las pruebas analizando el elastómero con herramientas CAD/CAE. El material base de las mangueras es un elastómero, por lo tanto, se realizó una metodología para obtener el modelo numérico con las propiedades hiperelásticas para conocer el comportamiento antes de llevarse a pruebas de construcción. El análisis de elementos finitos se realizó con un software especializado, que permitió el análisis de elastómeros con base a la metodología de la ASTM D412, referente a pruebas de hules vulcanizados sometidos a presión, estableciendo la geometría y las condiciones fronteras. Con el estudio se encontró que modelo constitutivo con mayor aproximación al comportamiento hiperelástico para hules vulcanizados fue el modelo de Marlow.
Implementación de un sistema de depósito químico en fase vapor asistido por filamento caliente (HFCVD) para la obtención del semiconductor trióxido de tungsteno (WO3)
Authors: Juan-Almazán Iván , Álvarez Gómez Karin Monserrat , López Roberto
Published: January 2024

Se obtuvieron polvos de trióxido de tungsteno (WO3) mediante un sistema de HFCVD (Hot Filament Chemical Vapor Deposition). Los polvos exhibieron tres diferentes coloraciones (azul rey, azul cielo y amarillo), debido al cambio del gas precursor usado (argón (Ar) o argón con vapor de agua (Ar+ H2O) o aire). Los polvos fueron evaluados por Difracción de Rayos-X (DRX) para la determinación de su estructura cristalina, su morfología fue observada mediante Microscopia Electrónica de Barrido (MEB), la composición química elemental se obtuvo por Espectroscopia de Energía Dispersiva (EDS). Por último, se analizaron las bandas de los enlaces presentes en el material con ayuda de Espectroscopia RAMAN. Estas técnicas lograron evidenciar la presencia del trióxido de tungsteno en los polvos obtenidos.
Diseño e implementación de un Autoencoder para la supresión de ruido de diferente naturaleza en imágenes de color
Authors: Miranda-González Armando Adrián , Rosales-Silva Alberto Jorge , Mújica-Vargas Dante , Escamilla-Ambrosio Ponciano Jorge , Vianney-Kinani Jean Marie , Ortíz-Rodríguez Floriberto
Published: January 2024

El presente artículo se centra en la propuesta de una red neuronal de tipo Autoencoder para la supresión de diversos tipos de ruido presente en imágenes de color. Existen diversos tipos de algoritmos para la supresión de ruido en imágenes como lo son las Redes Neuronales Convolucionales (CNN) los cuales requieren tanto de una gran cantidad de datos para su entrenamiento como de mayor carga computacional, aunque el mayor problema que estos presentan es que comúnmente se centran en un solo tipo de ruido causando que en algunas ocasiones la imagen no sea procesada de manera adecuada y al finalizar su tratamiento contenga pixeles corruptos los cuales causen que haya pérdida de detalles importantes dentro de la imagen. Por este motivo, esta propuesta proporciona evidencia de que el uso de autoencoders para la supresión de diversos tipos de ruidos en imágenes es factible, a través de este artículo se mostrarán resultados subjetivos y objetivos que determinarán la factibilidad del uso de este tipo de redes neuronales.
Pengaruh Persepsi Website Design Quality dan E-Service Quality terhadap E-Trust ‎ dan Repurchase Intention di Shopee
Authors: Jogja Mualim , Widowati Retno
Published: January 2024

Penelitian ini bertujuan untuk menguji serta menganalisis Pengaruh Persepsi Website Design Quality‎ ‎ dan E-Service Quality terhadap ‎E-‎Trust ‎ dan Repurchase Intention di Shopee. Jumlah sampel yang telah memenuhi kriteria dalam penelitian ini adalah 200 sampel menggunakan teknik pengambilan sampel nonprobabiliy dengan metode purposive sampling. Teknik pengumpulan data dalam penelitian ini menggunakan kuesioner elektronik dan disebarkan menggunakan Google Form. Penelitian ini menggunakan pendekatan kuantitatif dengan analisis Structural Equation Model (SEM). Alat statistik yang digunakan adalah software AMOS versi 24. Berdasarkan pengujian dan analisis menggunakan SEM, menunjukkan bahwa Website Design Quality‎ berpengaruh positif signifikan terhadap  E-‎Trust, E-Service Quality berpengaruh positif signifikan terhadap E-‎Trust, E-‎Trust berpengaruh positif signifikan terhadap Repurchase Intention, Website Design Quality‎ tidak berpengaruh secara langsung terhadap  Repurchase Intention, E-Service Quality tidak berpengaruh secara langsung terhadap Repurchase Intention, E-Trust memediasi penuh pengaruh Website Design Quality‎ terhadap Repurchase Intention. E-Trust memediasi penuh pengaruh E-Service Quality terhadap Repurchase Intention pada pelanggan Shopee.
 
This study aims to examine and analyze the Influence of Perceived Website Design Quality‎ and E-Service Quality on E-Trust and Repurchase Intention at Shopee. The number of samples that met the criteria in this study were 200 samples using a non-probability sampling technique with purposive sampling method. The data collection technique in this study used an electronic questionnaire and was distributed using the Google Form. This research uses a quantitative approach with Structural Equation Model (SEM) analysis. The statistical tool used is AMOS software version ‎‎24.‎ Based on testing and analysis using SEM, it shows that Website Design Quality has a significant positive effect on E-Trust, E-Service Quality has a significant positive effect on E-Trust, E-Trust has a significant positive effect on Repurchase Intention, Website ‎ Design Quality has no direct effect on Repurchase Intention, E-Service Quality has no direct effect on Repurchase Intention, E-Trust fully mediates the effect of Website Design Quality on Repurchase Intention. E-Trust fully mediates the influence of E-Service Quality on Repurchase Intention of Shopee customers.
Pengaruh Keterlibatan Merek dan Pengalaman Merek Terhadap Loyalitas Merek dengan Kepercayaan Merek sebagai Variabel Intervening
Authors: Putri Clarisa Nusantari Arya , Nadzir Muhammad Miftahun
Published: January 2024

Penelitian ini bertujuan untuk mengetahui pengaruh keterlibatan merek dan pengalaman merek terhadap loyalitas merek melalui kepercayaan merek sebagai pemediasi pada masyarakat yang menggunakan Traveloka. Teknik sampel pada penelitian ini menggunakan purposive sampling atau pengambilan sampel dengan kriteria. Kriteria yang digunakan yaitu masyarakat yang pernah menggunakan Traveloka minimal 2 kali dan berdomisili di Yogyakarta. Teknik pengumpulan data dalam penelitian ini menggunakan kuesioner berbentuk google form, dan terkumpul sebanyak 229 responden. Metode yang digunakan untuk analisis adalah path analysis dengan program spss versi 29. Hasil penelitian ini menunjukkan bahwa keterlibatan merek berpengaruh positif dan signifikan terhadap kepercayaan merek, pengalaman merek berpengaruh positif dan signifikan terhadap kepercayaan merek, keterlibatan merek berpengaruh positif dan signifikan terhadap loyalitas merek, pengalaman merek berpengaruh tidak signifikan terhadap loyalitas merek, kepercayaan merek berpengaruh positif dan signifikan terhadap loyalitas merek, kepercayaan merek memediasi keterlibatan merek terhadap loyalitas merek dan kepercayaan merek tidak memediasi pengalaman merek terhadap loyalitas merek.
 
This study aims to determine the effect of brand involvement and brand experience on brand loyalty through brand trust as a mediator in people who use Traveloka. The sample technique in this study used purposive sampling or sampling with criteria. The criteria used are people who have used Traveloka at least 2 times and are domiciled in Yogyakarta. The data collection technique in this study used a questionnaire in the form of a Google form, and collected 229 respondents. The method used for analysis is path analysis with the SPSS version 29 program. The results of this study indicate that brand engagement has a positive and significant effect on brand trust, brand experience has a positive and significant effect on brand trust, brand engagement has a positive and significant effect on brand loyalty, brand experience has a positive and insignificant effect on brand loyalty, brand trust has a positive and significant effect on brand loyalty, brand trust mediates brand engagement on brand loyalty and brand trust does not mediate brand experience on brand loyalty.
Model Strategi Digitalisasi dalam Kemampuan Dinamis Meningkatkan Kinerja Bisnis Berkelanjutan: Bukti Empiris dari UKM Indonesia
Authors: Anggraeni Oktanita Jaya , Amrulloh Muhammad Sholahuddin , Sulistyono Nantil Bambang Eko , Putra Mohammad Edwinsyah Yanuan
Published: January 2024

Studi ini bertujuan untuk menyelidiki hubungan antara kemampuan dinamis dan kinerja bisnis yang berkelanjutan di usaha kecil dan menengah Indonesia, serta dimensi apa yang berkontribusi pada pengembangan dan adopsi dalam strategi digitalisasi. Kami menganalisis sampel 596 UKM Indonesia menggunakan kerangka pengukuran yang divalidasi untuk mengeksplorasi tiga kelompok kegiatan DC di seluruh dimensi ekonomi, sosial, dan lingkungan. Temuan kami mengungkapkan bahwa pengembangan dan adopsi DC dapat secara signifikan meningkatkan strategi digitalisasi UKM, yang mengarah pada peningkatan inovasi model bisnis dan kinerja berkelanjutan. Peran mediasi strategi digitalisasi sangat penting dalam menjelaskan hubungan antara DC dan kinerja bisnis yang berkelanjutan. Implikasi praktis dari penelitian kami dapat bermanfaat bagi UKM di Indonesia dan sekitarnya karena mereka berusaha untuk meningkatkan strategi digitalisasi dan mencapai keunggulan kompetitif yang berkelanjutan.
Developing an Australian dust early warning system
Authors: Clark Tegan , Strong Craig
Published: January 2024

In Australia, the perception of large continental-scale dust storms has traditionally been restricted to aspects of ‘inconvenience’ or ‘novelty’. However, as the climate changes, there is an increased likelihood of dust storm activity that puts communities at increased risk. The aim of this study was to explore the need and possibility of developing a dust early warning system for Australia. Through a scoping review of internationally used sand and dust early warning systems, we found that an array of systems exist or were theoretically tested in the Northern Hemisphere. The sensor networks, one of which was operational, were of particular interest because Australia already has an operational air quality network that could be expanded to a dust early warning system. The need for a trans-boundary system is critical for Australia and, therefore, requires a combined approach of expanded sensor network with satellite-based systems to increase validation of any future modelling approach. This improved understanding could inform the development of a dust warning system for multi-socio-economic factors that account for cumulative exposure to small, localised and large continental-sized dust events.
Short Communication: Rare record of a southern right whale (Eubalaena australis Desmoulins, 1822) with calf in Ilhéus, Bahia, northeastern Brazil
Authors: Foucart Thomas , De Moura Lima Alice
Published: January 2024

This note reports an unusual observation of a mother and calf pair of southern right whales on 27 July 2021 oﬀ the coast of Ilhéus, Bahia state, northeastern Brazil. The sighting was made from a 29ft cruiser boat (brand Cabrasmar), with a 225HP inboard engine, during a whale watching tour in a humpback whale (Megaptera novaeangliae) breeding area.
Population biology, conservation threats and status of Mediterranean striped dolphins (Stenella coeruleoalba)
Authors: Aguilar Alex
Published: January 2024

The paper reviews the information available on those aspects of the biology, ecology and effects of human impact that are relevant to the management and conservation of striped dolphins in the Mediterranean Sea. The striped dolphin is common throughout the western Mediterranean, although it shows a preference for open waters beyond the continental shelf. In 1991, the western Mediterranean population was estimated as 117,880 (95% CI = 68,379-214,800), but no comparable estimates are available for the eastern basin. Geographical variation in body length, skull morphometrics and genetic analyses, as well as the geographic range and evolution of the 1990-1992 epizootic, suggest some degree of isolation between dolphins in different regions within the Mediterranean and independence from those in the Atlantic. Growth and reproductive parameters in the Mediterranean are, overall, similar to those of other populations, with the exception of age at sexual maturity, which in both sexes is extremely high (11-12 years). Tissue levels of organochlorine compounds, some heavy metals and selenium are high and exceed threshold levels above which detrimental effects commonly appear in mammals. However, apart from the indication that these levels may have acted as triggering factors in the 1990-1992 epizootic by depressing the immune system of diseased individuals and potential lesions in the ovaries, no information on pollutant-related effects is available. The 1990-1992 epizootic devastated the whole Mediterranean population; over one thousand corpses were examined in the western Mediterranean alone, but the toll was probably much higher. The causative agent of the die-off was a morbillivirus, but the effect of some pollutants and decreased food availability were suggested as triggering factors. Depletion of fish and cephalopod resources is widespread in the Mediterranean and, given that the diet of striped dolphins includes commercial species, this undoubtedly has a potential for limiting population numbers. A number of fishing activities produce an associated striped dolphin bycatch. In particular, the pelagic driftnet fishery for tuna and swordfish, carried out by boats from Italy, Spain and Morocco, produces a significant kill in various locations. Variation in sighting and stranding frequency suggests that striped dolphins may have increased their numbers in recent decades. However, this progressive increase may have run parallel to a reduction in carrying capacity of its habitat. This suggestion is supported by the late age at attainment of sexual maturity observed in the Mediterranean population as compared to other conspecific or even congeneric populations.