bluuebunny/crossref_metadata_2025 huggingface dataset:
Tracking longitudinal genetic changes of circulating tumor DNA (ctDNA) in advanced Lung adenocarcinoma treated with chemotherapy
Authors: Han Xiaohong , Han Ying , Tan Qiaoyun , Huang Yu , Yang Jianliang , Yang Sheng , He Xiaohui , Zhou Shengyu , Song Yan , Pi Jinping , Zuo Lijie , Yao Jiarui , Wu Di , Zhang Zhishang , Shi Yuankai
Published: October 2019

Introduction

Pemetrexed combined with platinum complexes can be used as first-line treatment for advanced non-squamous non-small cell lung cancer (NSCLC), however, the efficacy and safety is varying from individuals. There is a need to better understand the genetic variations associated with platinum response.

Materials and Methods

We performed next-generation sequencing (NGS) based on BGI Oseq-ctDNA panel to analyze 98 longitudinal plasma samples from 32 lung adenocarcinoma patients during platinum-based chemotherapy, and a bioinformatic pipeline was developed to detect point mutations.

Results

We found that mutation burden was decreased after chemotherapy, which reflected chemotherapy sensitivity, especially the frequency of C>G and C>A substitutions. Moreover, neoplastic cells carrying a specific set of somatic mutations, such as EGFR(L858R), KRAS (p.G12C) were obviously correlated with platinum treatment. In addition, the MAPK pathway was found to have a pivotal role in NSCLC and platinum based response. Finally, we found that smokers benefit less from platinum-based chemotherapy.

Conclusions

Collectively, this work described the dynamic changes of ctDNA mutation status during platinum-based treatment, which may contribute to advanced lung adenocarcinoma patients stratification and precision treatment.
DNA methylation is maintained with high fidelity in the honey bee germline and exhibits global non-functional fluctuations during somatic development
Authors: Harris Keith D. , Lloyd James P. B. , Domb Katherine , Zilberman Daniel , Zemach Assaf
Published: October 2019

Background

DNA methylation of active genes, also known as gene body methylation, is found in many animal and plant genomes. Despite this, the transcriptional and developmental role of such methylation remains poorly understood. Here, we explore the dynamic range of DNA methylation in honey bee, a model organism for gene body methylation.

Results

Our data show that CG methylation in gene bodies globally fluctuates during honey bee development. However, these changes cause no gene expression alterations. Intriguingly, despite the global alterations, tissue-specific CG methylation patterns of complete genes or exons are rare, implying robust maintenance of genic methylation during development. Additionally, we show that CG methylation maintenance fluctuates in somatic cells, while reaching maximum fidelity in sperm cells. Finally, unlike universally present CG methylation, we discovered non-CG methylation specifically in bee heads that resembles such methylation in mammalian brain tissue.

Conclusions

Based on these results, we propose that gene body CG methylation can oscillate during development if it is kept to a level adequate to preserve function. Additionally, our data suggest that heightened non-CG methylation is a conserved regulator of animal nervous systems.
Mulching as water-saving technique in dryland agriculture: review article
Authors: Kader Mohammad Abdul , Singha Ashutus , Begum Mili Amena , Jewel Arif , Khan Ferdous Hossain , Khan Nazrul Islam
Published: October 2019

Agricultural water resources have been limited over the years due to global warming and irregular rainfall in the arid and semi-arid regions. To mitigate the water stress in agriculture, mulching has a crucial impact as a water-saving technique in rain-fed crop cultivation. It is important mainly for preserving soil moisture, relegating soil temperature, and limiting soil evaporation, which affects the crop yield. Mulching has many strategic effects on soil ecosystem, crop growth, and climate. Mulch insulates the soil, helping to provide a buffer from cold and hot temperatures that have a crucial activity in creating beautiful and protected landscapes. This study has accumulated a series of information about both organic and plastic mulch materials and its applicability on crop cultivation. Moreover, future research potentials of mulching with modeling were discussed to quantify water loss in agriculture.
Valuation of intangible assets and intellectual property
Authors: Федотова Марина , Fyedotova Marina , Леонтьев Борис , Leontev Boris , Мамаджанов Хамид , Mamadzhanov Hamid , Лосева Ольга , Loseva Ol'ga , Игнатов Евгений , Ignatov Evgeniy , Тазихина Татьяна , Tazikhina Tatyana , Сычева Екатерина , Sycheva Ekaterina , Леонтьева Валерия , Leont'eva Valeriya
Published: October 2019

The textbook discusses the concepts and types of intangible assets (IA) and intellectual property (IP), information and regulatory framework for their identification and evaluation. The methods of valuation of IA and IP within each approach are given, examples of determining the value of IA and IP by different methods are given. Specific intellectual assets — domain names and client bases, methods of their evaluation are considered. The requirements to the report on assessment of IA and IP are characterized and the example of the report on assessment of trademarks is analyzed. At the end of each Chapter, control questions and practice-oriented tasks are presented.
Meets the requirements of the Federal state educational standards of higher education of the last generation.
It is intended for bachelors and undergraduates studying in the direction of "Economics", as well as for graduate students, teachers, researchers and specialists in the field of valuation.
Dementia 4. Lewy body dementia: diagnosis, treatment and medical management
Authors: Nazarko Linda
Published: October 2019

In the UK, an estimated 954 000 people have dementia. Lewy body dementia (LBD) can be difficult to diagnose and estimates of its prevalence in the UK range from 38 000–100 000 ( Prince et al , 2014:14, 16; Table 4, 2019 estimates; NHS, 2019 ).

This article, the fourth in a series, explains about the pathophysiology and clinical features of LBD, how it is diagnosed, treated and managed
Bowel cancer screening programme
Authors: Peate Ian
Published: October 2019

This article, third in the series concerning screening programmes, considers the bowel cancer screening programme. In the UK, all four countries offer a bowel cancer screening programme to women and men.

The overall aim of this screening programme is to check for bowel cancer— or any abnormalities that could lead to bowel cancer. The healthcare assistant and assistant practitioner (HCA and AP) may be required to assist the patient with regards to some aspects of bowel screening.

This article provides an overview of the lower gastrointestinal tract and a brief description of signs and symptoms of bowel cancer. There are age differences in Northern Ireland, Wales and England compared to Scotland.

The article describes the fundamental principles underpinning bowel cancer screening programmes.
Measuring sensory and pain thresholds by Semmes-Weinstein monofilaments in patients with leg ulcers: a pilot study
Authors: Jansen Mark MPM , van de Ven Aukje ALM , van der Valk Pieter GM , Wilder-Smith Oliver HG
Published: October 2019

Objective:

Pain is a common and disabling symptom in patients with leg ulcers. Clinical quantification of pain mostly depends on subjective pain reports, which do not reveal underlying mechanisms. The aim of this pilot study is to identify mechanisms underlying the pain in patients with leg ulcers by documenting alterations in pain processing using quantitative sensory testing.

Methods:

In nine ulcer patients the mechanical sensory thresholds and the mechanical pain thresholds were determined by Semmes-Weinstein monofilaments (SWM) at three different sites: on the contralateral (unaffected) leg, on the skin of the affected leg 10cm from the ulcer margin, and on the affected leg, close (1–2cm) to the ulcer margin. Besides the mechanical sensory thresholds and mechanical pain thresholds, pain at the site of the ulcer, using an 11-point numeric rating scale (NRS), was documented.

Results:

Mechanical sensory thresholds were increased in all subjects. Almost half (44%) of patients consistently showed allodynia at the unaffected site. The lowering of mechanical pain thresholds correlated with higher scores on the NRS.

Conclusion:

All patients showed diminished touch and/or protective sensation, which might have contributed to ulcer development via (partial) loss of protective function. The allodynia at the unaffected site suggests the presence of central sensitisation of pain processing.
Free skin micrografts with cyanoacrylate as outpatient treatment for venous leg ulcers
Authors: Sánchez Ferrán Plá , Rial Rodrigo , Artero Iñaki Cernuda , Álvarez Pilar Ruíz , Ducajú Guillermo Moñux , López Isaac Martínez , Fernández Maday Cabrero , Cabeza Oscar Uclés , Hernando Francisco Javier Serrano
Published: October 2019

Objective:

The present study describes an ambulatory, free skin micrograft technique with cyanoacrylate as a coadjuvant venous leg ulcer (VLU) healing strategy and its outcomes after one month.

Methods:

This prospective study involved Comprehensive Classification System for Chronic Venous Disorders (CEAP) stage C6 patients with good granulation tissue and negative culture results, consecutively recruited in January 2017 in the Hospital Clinico San Carlos. A skin micrograft was harvested from the anterior surface of the patient's thigh with a 0.4cm punch (0.12cm2). The graft was adhered to the ulcer bed with cyanoacrylate. Anti-adherent dressing and double-layer bandaging was applied, with weekly replacements. Measurements were obtained of the surface of the VLU and graft progression (in cm2) using a photographic grid.

Results:

A total of 12 VLUs in 12 patients were included, with a mean treated surface of 20.32±13.9cm2. A total of 18 grafts were placed and all were found to be viable after one week. Average graft growth was not noticeable after one week but was found to be 0.25±0.08cm2 after week two, 0.41±0.98cm2 after week three, and 0.70±0.15cm2 after week four (p<0.001). There were no complications in the donor zone.

Conclusion:

The findings of this study show that free skin micrografting with cyanoacrylate as outpatient treatment for VLUs was simple, rapid and without complication in this study, and may contribute to its wider application in clinical use.
Biomarkers of Systemic Lupus Erythematosus and Systemic Sclerosis diseases activity in a sample of Egyptian patients :Soluble Intercellular Adhesion Molecule-1 and Soluble Interleukin-2 Receptor, Case Control Study
Authors: A. Hegazy Gehan , Shaker Olfat , Sayed Safaa , Elzaher Amr Abd , Fathy Khaled , Wahby Iman , Elsamanoudy Ayman , Mustafa Hesham N.
Published: October 2019

Systemic Lupus Erythematosus (SLE) and systemic sclerosis (SSc) are systemic inflammatory autoimmune disorders characterized by a large spectrum of clinical and laboratory features. The aim of the present study was to investigate the possible use of serum level of soluble intercellular adhesion molecule-1(sICAM-1) and soluble interleukin-2 receptor (sIL-2Ra) as biomarkers for monitoring of SLE and SSc disease activity. Moreover, it aimed to compare the specificity and sensitivity as well as cut-off value of both biomarkers in a sample of Egyptian patients. 50 SLE patients, 30 SSc patients and 60 age and sex matched healthy controls were enrolled in our study. sICAM-1and sIL-2Ra were measured in serum samples obtained from all participants. In addition to Erythosedimentation rate (ESR), complete blood count (CBC), Antineuclearantibodies (ANA) estimation, disease activity of both diseases were also assessed. sICAM-1and sIL-2Ra levels were higher in SLE and SSc patients versus control. Both parameters are correlated with each other as well as the activity parameters. A cut-off levels of 455.59 (ng/ml) &2525935 (pg/ml) in both SLE & SSs respectively was observed with the highest specificity and sensitivity. It could be concluded that sICAM-1 and sIL-2Ra are noninvasive biomarkers for SLE and SSc that could play a pathophysiologic role in development and progression of both diseases. Moreover, sICAM-1 and sIL-2Ra are correlated with the disease activity at cut-off values of 455.59 (ng/ml) & 2525935(pg/ml) respectively.
Mi comienzo como enfermero. Una narración personal
Authors: Marrero González Cristo Manuel
Published: October 2019

Con el presente manuscrito tan solo pretendo narrar de una forma breve y personal mis principales vivencias al comenzar a trabajar como enfermero en un hospital de Tenerife (España). Esto aconteció en el segundo semestre de 2009. Reflexiono sobre lo vivido y además intento argumentar mis vivencias apoyándome en los conocimientos que he adquirido elaborando una tesis doctoral fenomenológica en la que estudio este acontecimiento con enfermeras que comienzan a trabajar en diferentes instituciones sanitarias de Tenerife.
Materia en el dolor usada. La poesía de Francisco Alonso Ruiz
Authors: Valero Gómez Manuel
Published: October 2019

Aunque poca conocida, la trayectoria poética del alicantino Francisco Alonso Ruiz Pérez (1948-2018) establece –decisivamente– un puente entre dos orillas que parecen irreconciliables para el género en la ciudad de Alicante: la brillante y esplendorosa primera promoción de poetas de la posguerra alicantina y aquellas generaciones más próximas en el tiempo. En todo caso, su reciente y sorpresivo fallecimiento ha hecho más urgente la ordenación y el estudio de una obra que rebasa más de medio siglo dedicado a la actividad cultural. Ténganse en cuenta su evidente drama textual, anonimato entre la bohemia provinciana y desfase respecto a cualquier horda generacional. El siguiente artículo pretende identificar algunos signos visibles de aquello que podríamos denominar poética.
Academia Brasileira de História da Enfermagem: 2007 a 2014
Authors: Fabio Fabio Soares de Melo , Fernandes de Freitas Genival , Barrionuevo Bonin Bárbara
Published: October 2019

Este estudo objetiva compreender como, por quê e para que, um grupo de enfermeiros e pesquisadores da História da Enfermagem optou pela criação da Academia Brasileira de História da Enfermagem, em 2010. Este estudo objetivou descrever as motivações e expecativas dos enfermeiros e pesquisadores nesse campo, bem como identificar as circunstâncias históricas, lutas e forças políticas envolvidas na criação dessa instituição. Observa-se que os atores sociais envolvidos na criação da entidade eram provenientes do Grupo de Pesquisa “História e Legislação da Enfermagem” e que as forças e lutas políticas davam-se entre os pesquisadores da história da enfermagem pois havia interesses díspares na criação dessa entidade. Dentre as contribuições da Academia destaca-se a luta pela continuidade do ensino da história da enfermagem nas instituições formadoras, sendo a realização do I Simpósio Ibero Americano de História da Enfermagem, em 2007, a propulsão para sua criação.
Dinamika dan Evolusi Pantai Probolinggo, Jawa Timur
Authors: Suyarso Suyarso
Published: October 2019

Dynamics and Evolution of the Coast of Probolinggo, East Java. The coastal plain of Probolinggo extends from Tongas Subdistrict in the western part to Kraksaan Subdistrict in the eastern part. The south side is the fertile rice field area, while the north side is the fish pond area. The phenomena of coastal changes in Probolinggo are strongly influenced by the materials supplied from Mount Bromo. This research was conducted in April–May 2012, February 2013, and August 2014 and aimed to gain insight into the coastal dynamics and evolution as well as changes and land cover convertion in Probolinggo. The analysis of coastal changes in Probolinggo from 1973 until 2013 was done using multitemporal landsat imageries, the measurement and drawing of coastal profile were carried out using shokiza geodetic instrument and SeaBird Electronic tide gauge. The results showed that in the western part, the accretion process is still ongoing, while in the eastern part, the accretion speed since 1989 has continued to decline and even some places experienced erosion. The new coastal plain formed by the accretion of marine processes is utilized by the residents as fish ponds, whereas accretion formed by fluvial processes is utilized as rice fields.
Kondisi dan Keanekagaragaman Karang Batu di Perairan Sabang
Authors: Utama Rizkie Satriya , Budiyanto Agus
Published: October 2019

Condition and Diversity of Stony Corals in Sabang Waters. Globally, coral reefs are facing a variety of threats, both natural and human activities. Coral reefs in the waters of Sabang in 2004 were hit by a tsunami and in 2010 an increase in sea surface temperatures caused a bleaching. These resulted in mass mortality of stony corals. This study aims to determine the current condition and the diversity of stony corals in Sabang waters. The study was conducted in May 2015 in ten stations spread over four islands, namely Pulau Weh, Pulau Rondo, Pulau Breueh, and Pulau Nasi Besar. The coral cover is calculated using Underwater Photo Transect (UPT) method. The images were analyzed using CPCe 4.1 program with 30 random points in each frame. The number of species and the number of coral colonies are calculated based on the number of species and coral colonies contained in the photo frames along the transect. Based on the results of the analysis, live coral cover ranged 22.45–58.60% with an average live coral cover of 41.99%. Throughout the transect, 148 species of stony corals from 37 genera and 15 families were discovered. In general, stony corals in Sabang waters are in a good condition, not different from the condition of coral reefs in 2005. Open waters have a positive impact on coral growth, especially for the genus Acropora.
Molluscs Diversity in Coastal Ecosystem of South Biak, Papua
Authors: Aji Ludi Parwadani , Widyastuti Andriani
Published: October 2019

Coastal areas of Biak Island consist of three major ecosystems: the mangrove, seagrass beds, and coral reefs where a variety of molluscs live. Mollusc diversity in South Biak waters was investigated in September 2011. The observation was conducted at 4 locations, i.e. Paray, Ambroben, Yenures, and Sorido with 2 stations at each location. The study aimed to obtain information on the diversity and community structure of the benthic molluscs (gastropods and bivalves) on the coastal areas of South Biak waters. Sampling method applied was quadrate-transect line in intertidal areas from inshore to offshore. The molluscs (epifauna and infauna) found inside the quadrate-transect were counted and identified. The result showed high benthic mollusc diversity with a total of 94 species, consisting of 75 species of gastropods and 19 species of bivalves. The most widespread gastropod found in all stations was Nassarius sp., while for bivalves was Tellina sp. The highest value of diversity index (H) was 2.96 found in Paray 1 and the lowest was 0.58 in Yenures 1. The Evenness index (E) and Simpson index (D) ranged from 0.27 to 0.96 and from 0.06 to 0.72 respectively. Species richness (d) ranged from 2.89 to 6.84 and similarity index from 3.90 to 42.40.
Komposisi Spesies dan Struktur Komunitas Moluska Bentik Teluk Jakarta
Authors: Cappenberg Hendrik
Published: October 2019

The Composition of Species and Structure of Benthic Mollusc of Jakarta Bay. The development and increasing of population in mainland may have negative impact on water and sediment quality in the Jakarta Bay as habitat of benthic molluscs. The study was conducted in June and September 2003. The aim of this study was to observe the species composition and diversity of benthic mollusc community in the Jakarta Bay. Samples were collected from 30 stations at 1 – 12 m depth using Smith McIntyre Grab with opening area was 0.05 m². A sieve with 0.5 mm in mesh size used for collecting benthic molluscs as well as for determining the profil of benthic substrates. Results of this study showed that the substrate in the study sites was characterized by muddy, muddy sand and sandy mud sediment. A total of 24 mollusc species were identified, which belong to 18 genera. Abundance of benthic molluscs ranged from 0.3 to 15779.7 individu/m2 in June and from 0.3 to 820.3 individu/m2 in September. Tellinidae was the highest species composition, and Alveinus sp. (Kelliellidae) was distributed widely in June and September. Most of the molluscs found in this study area were common species in Indonesia waters. The value of diversity index (H’) ranged from 0.03 to 0.95 and evenness index (J’) ranged from 0.05 to 0.69 in June and in September diversity index (H’) ranged from  0.01 to 1.08 and evenness index (J’) ranged from 0.01 to 1.00. These indexes showed that the diversity of benthic mollusc in Jakarta Bay were relatively low.
Sumberdaya Kuda Laut (Hippocampus spp.) di Perairan Pulau Bintan, Teluk Lampung dan Pulau Tanakeke
Authors: Putri Masayu Rahmia Anwar , Suryandari Astri , Haryadi Joni
Published: October 2019

Seahorse Resources (Hippocampus spp.) in the Waters of Bintan Island, Lampung Bay and Tanakeke Island.Information on seahorse resources is very limited, from 35 species of marine species listed on the IUCN redlist, 20 species are listed as "data deficient" which illustrates the lack of information related to sea horses, even for highly exploited species. This research was conducted to inventory sea horse resources (Hippocampus spp.), covering spesies information, size, sex ratio and density of seahorses from three potential locations, they are Bintan Island, Lampung and Tanakeke Island Waters. Field observation for seahorse resources was conducted at Bintan Island (Riau Islands Province) in March 2016, Lampung Bay (Lampung Province) in May 2016 and Tanakeke Islands (Takalar Regency, South Sulawesi) in June 2016 by purposive sampling method, interview with fisherman and collector and also literature study. A total of 5 seahorse species were found in three research locations, 4 species found in Bintan waters (H. comes, H. spinossisimus, H. hystrix and H. kuda), 2 species found in Lampung Bay (H. comes and H. kuda) and only 1 species found in Tanakeke (H.barbouri). Most of seahorse found during the study were categorized as sexually mature, dominated with seahorse 11-12 cm in size. The different types and densities of seahorses in the three study sites are supported by differences in habitat where seahorses are occupied. The density of seahorses tended to be low due to over-exploitation, environmental change and habitat damage. Management measures based on biological aspects and ecological conditions of each region need to be carried out for sustainable seahorse fisheries.
Komunitas Ikan Karang di Pulau Ternate dan Sekitarnya
Authors: Utama Rizkie Satriya , Edrus Isa Nagib , Makatipu Petrus Christianus
Published: October 2019

Reef Fish Community in the Adjacent Waters of Ternate Island. Considering that the development of coastal region in the North of Moluccas may affect the population of reef fishes, a research on coral reef community structure is performed using underwater visual cencus on a permanent belt transect. The selected indicator monitoring used were eight families of reef fishes. A total of 108 species of reef fishes were identified, consisted of 31 species of corallivorous, 45 species of herbivorous fishes and 32 species carnivorous fishes (based on punctuation group). Density means of a corallivorous group is 1.598 ± 283 individual/ha, a herbivorous group is 4.751 ± 1.034 individual/ha, and a carnivorous group is 890 ± 622 ekor/ha. The average of reef fish stocks is 420 ± 162 kg/ha that consist of 320 ± 130 kg/ha for herbivorous fishes and 100 ± 64 kg/ha for carnivorous fishes. Indicator fish dominance were attained by Chaetodon baronessa, C. kleinii, C. lunulatus, C. melannotus, C. octofasciatus, C. trifascialis, and Heniochus varius. Herbivorous fishes (84%) more dominat than carnivorous (16%) in terms of individual composition. Dominant species of herbivorous fishes included Acanthurus pyroferus, Chlorurus bleekeri, C. Sordidus, Ctenochaetus binotatus, C. striatus, Scarus dimidiatus, S. ghobban, Siganus vulpinus, and Zebrasoma scopas. The one of carnivorous fishes dominated was only Lutjanus biguttatus. Increasing trend of species numbers and density for corallivorous, herbivorous and carnivorous fishes occured from 2015 until 2017 in majority of study sites. In contrast, the biomass values not increased in majority of the sampling sites.
Isolasi dan identifikasi bakteri toleran logam berat dari sedimen mangrove di Pengudang dan Tanjung Uban, Pulau Bintan, Indonesia
Authors: De Fretes Charlie Ester , Sutiknowati Lies Indah , Falahudin Dede
Published: October 2019

Isolation and Identification of Heavy Metals Tolerant Bacteria from Mangrove Sediment in Pengudang and Tanjung Uban, Bintan Island, Indonesia. Bacterial searches for remediation of heavy metal pollutants continue to be carried out due to the increasing pollution in the ecosystem as a result of industrialization. This research aims to identification bacteria strains that are tolerant of heavy metals from mangrove sediments in the Pengudang and Tanjung Uban, Bintan Island in 2018. Bacterial isolation was carried out by pour plate method and purified using marine agar (MA) medium. Screening of bacterial isolates was carried out by growing isolates on MA medium with the addition of 100 ppm Pb. In addition, the determination of minimum inhibitory concentration (MIC) was performed on the isolates were tolerant to Pb, Cu, and Cd by addition of heavy metals in 50-1000 ppm concentrations. Identification of heavy metal tolerant isolates was carried out by sequencing the 16S rRNA gene. The results of bacterial isolation from mangrove sediments obtained 48 isolates used for testing the ability of heavy metals tolerant. Screening tests showed that PGD1A, PGD5A, PGD22A, PGD1B, PGD9B, PGD5C, PGD6C, TJU1, TJU5, and TJU7 isolates were heavy metal resistant. The results showed that bacterial isolated from mangrove sediments had MIC values of 800-900 ppm for Pb, 100-800 ppm for Cu and 100-200 ppm for Cd. There are 3 isolates that have high resistance to three kinds of heavy metals such as Bacillus oceanisediminis PGD1A, Vibrio alginolyticus PGD5A, and Halobacillus kuroshimensis PGD9B. This indicates that the isolate can be used efficiently for removal of heavy metals from the ecosystem.
Pengukuran Total Petroleum Hidrokarbon (TPH) Melalui Pendekatan Kadar Minyak-Lemak dalam Sedimen di Perairan Delta Cimanuk, Jawa Barat
Authors: Wulandari Ita , Yogaswara Deny , Khozanah Khozanah , Edward Edward , Rositasari Ricky , Falahudin Dede
Published: October 2019

Determination of Total Petroleum Hidrokarbon (TPH) through the Concentration of Oil and Grease (OG) in the Surface Sediment of Cimanuk Delta Waters, West Java. The Estuary of Delta Cimanuk is located in the coastal water of Indramayu, West Java. The pollution in the Cimanuk Delta was originated from households and industrial waste on coastal dan upland areas. Coupled with the traffic activities of fishing vessels at the fish landing (PPI) and fishing port (PP) bases around the waters, oil and grease contamination would be a threat as pollution in Indramayu coastal area. The major source of OG component on coastal waters was animal and vegetal fat and total petroleum hydrocarbon (TPH). The objectives of the study are to estimate the concentration and spatial distribution of TPH in the sediments of the Cimanuk watershed based on OG levels, and identifying the distribution of TPH-contaminated areas. Fourier Transform Infrared Spectroscopy (FTIR) instrument was applied to determine OG compounds in the sediment samples.  The results showed that OG concentrations in sediments were varied between <1 to 138.104 mg kg-1 dry weight (dw), while TPH was estimated at 0.24 – 36.60 mg kg-1 dw. The highest concentrations of OG was observed on St-10 in the northeast coast. Compared to the threshold value of sediments quality guidelines according to ANZECC (OG: 280-550 mg kg-1 dw), the TPH levels in eighteen observation stations were within normal range. The increased pollutant intake in Cimanuk watershed will threat the estuary as well as its biodiversity.
PROCESOS EDUCATIVOS DE LOS MOVIMIENTOS SOCIOAMBIENTALES DEL OCCIDENTE DE MÉXICO: el caso del Comité Salvabosque en el Bosque El Nixticuil, Zapopan
PROCESSOS EDUCATIVOS DOS MOVIMENTOS SOCIOAMBIENTAIS DO OESTE DO MÉXICO: o caso do Comité Salvabosque na Floresta de El Nixticuil, Zapopan
EDUCATIONAL PROCESSES OF THE SOCIO-ENVIRONMENTAL MOVEMENTS OF THE WEST OF MEXICO: the case of the Comité Salvabosque in El Nixticuil Forest, Zapopan.
Authors: Ortega Laura Karina Mares , Rivera Laura Sofía Herrera , Herrera Andrea Rivera
Published: October 2019

Este artículo forma parte de los resultados de una investigación realizada en la Maestría en Educación Ambiental de la Universidad de Guadalajara. En ella se analizan los procesos educativos de los movimientos socioambientales con la finalidad de construir un diálogo entre éstos actores y la educación ambiental propiciando puentes vincular a ambos escenarios, ligados por ideales pero distanciados. Para lo cual camina hacia el análisis tanto de las prácticas formativas como de los discursos pedagógicos, presentes en los movimientos socioambientales, particularmente en el Comité Salvabosque, cuyo núcleo de integrantes habita en las periferias del bosque El Nixticuil, amenazado por el crecimiento urbano desmedido de la ZMG.

Este trabalho faz parte dos resultados de uma pesquisa realizada no Mestrado em Educação Ambiental da Universidade de Guadalajara. Discute os processos educativos dos movimentos socioambientais, a fim de construir um diálogo entre esses atores e a educação ambiental, proporcionando pontes articuladas aos dois cenários, ligadas por ideais, mas distanciadas. Para o qual caminha para a análise tanto das práticas de formação quanto dos discursos pedagógicos, presentes nos movimentos socioambientais, particularmente no Comitê Salvabosque, cujo núcleo de integrantes vive na periferia da floresta El Nixticuil, ameaçado pelo crescimento urbano excessivo da ZMG.

This article is part of the results of a research carried out in the Master in Environmental Education of the UdG. It discusses the educational processes of socio-environmental movements in order to build a dialogue between these actors and environmental education providing bridges link to both scenarios, linked by ideals but distanced. For which it moves towards the analysis of both the training practices and the pedagogical discourses, present in socio-environmental movements, particularly in the Salvabosque Committee, whose nucleus of members live in the outskirts of the El Nixticuil forest, threatened by the excessive urban growth of the ZMG.
Clinical and cytogenetic examinations of patients with transsexualism
Authors: Kozlov G. I. , Kalinchenko S. Yu. , Slonimsky B. Yu. , Kurilo L. F. , Abakumova N. S. , Mkhitarova Ye. V. , Shileiko L. V.
Published: October 2019

Patients with male and female transsexualism were examined using clinical, cytogenetic, gametological and morphological methods. All patients were shown to possess normal karyotype without disorders in chromosome number or structure. Signs of sclerocystic ovaries were detected in 25% of patients with female transsexualism before treatment; after androgen therapy of 1 to 3 years signs of sclerocystic ovaries and folliculogenesis suppression were observed in 100% cases. All the patients with male transsexualism presented with spermatogenesis in the form of oligoasthenoteratozoospermia and degeneration of immature sex cells before therapy.
Thyroxine treatment of patients with thyroid diseases, foreign experience and its use in Russia (lecture)
Authors: Gerasimov G. A.
Published: October 2019

Thyroxine is one of the 13 most commonly prescribed drugs in the United States. Thyroxine is even more frequently prescribed to patients in several countries of Western Europe, where, due to iodine deficiency, there is a high prevalence of thyroid diseases. Indication for the use of thyroxine is either conventional replacement therapy in patients with hypothyroidism, or blocking the secretion of thyroid stimulating hormone (TSH) in patients with nodular goiter or after surgery for thyroid cancer. Hypothyroidism is a common disease: according to foreign authors, from 1.5 to 2% of women and about 0.2% of men suffer from it. Among people over 60, the prevalence of hypothyroidism is even higher: up to 6% of women and 2.5% of men have a TSH level that is 2 times higher than the upper limit of normal. According to foreign studies conducted in areas without iodine deficiency (UK), thyroid nodules are found in 0.8% of men and 5% of women, and the frequency of nodes increases after 45 years. In areas with iodine deficiency in the biosphere, which includes the vast majority of the territory of Russia, the frequency of nodular goiter in women of reproductive age reaches 10% or more. Thyroid cancer is the most common endocrine localization of malignant tumors. In 1984, 10,000 new cases of thyroid cancer were reported in the United States. For a long time, the selection of thyroxine doses for substitution and suppressive therapy was purely empirical and was based mainly on clinical signs: dynamics of mass, pulse, disappearance of myxedema, etc. At present, there are objective methods for controlling the thyroxine dose.
Atherogenic potential of the blood serum in patients with type 1 diabetes mellitus
Authors: Shagaeva M. M. , Sobenin I. A. , Slavina L. S. , Orekhov A. N.
Published: October 2019

The task of this research was to study exogenous insulin effect on blood serum atherogenic potential in patients with type I diabetes mellitus. Under study were relationship between blood serum atherogenic potential in diabetics and daily insulin dose and duration of therapy, as well as exogenous insulin effect on the major atherosclerotic manifestations in tissue cultures, such as intracellular cholesterol content in cultured cells and labeled thymidine incorporation in cellular nuclei DNA. Blood serum atherogenicity did not correlate with insulin dose and duration of insulin therapy both in adult patients and children. Insulin prescription to newly detected patients with type I condition did not influence blood serum atherogenic potential. Exogenic insulin did not influence the major atherosclerotic manifestations at the cellular level, namely, on intracellular cholesterol content in cultured cells and these cells proliferative activity; it had no influence on blood serum atherogenic potential of the patients with type I condition.
Information on the III plenum of the Russian Association of Endocrinologists
Authors: Balabolkin M. I.
Published: October 2019

On May 1113, 1995, the 3rd Plenum of the Russian Association of Endocrinologists on the organization of care for patients with diabetes was held in Moscow (Center for Rehabilitation of the Sanatorium named after A. I. Herzen). The agenda included two issues: monitoring late complications of diabetes mellitus and discussing the federal diabetes mellitus program. In his opening remarks, the chairman of the Russian Association of Endocrinologists acad. RAMS I. I. Dedov highlighted the state of medical care in Russia. In recent years, there has been a steady decline in specialized care for patients with diabetes, in particular insulin supply. According to the reports of the chief endocrinologists of the regions and territories, over the past 3 years there have been situations when out of all insulin preparations only insulin or short-acting, or medium-acting, were available. This situation was observed not only in remote areas, but even in Moscow and the Moscow region. The acceleration of the convocation of the plenum of the Russian Association of Endocrinologists was due to a serious situation that arose in connection with the entry into medical practice of insulin of Russian-Polish production in violation of the order established by the Pharmacological Committee of the Russian Ministry of Health.
Association of multinodular euthyroid goitre with some genetic markers
Authors: Makarov A. D. , Bazarova E. N. , Kozlov G. I.
Published: October 2019

Distribution of blood groups ABO, Rh, Pu and MN was studied in 85 patients with multinodular euthyroid colloid goitre. An association has been revealed between the presence of this disease and MN blood group, as well as the absence of Pi antigen. These results permit us considering MN blood group and P| antigen absence as factors of risk for multinodular euthyroid colloid goitre.
Indirect calorimetry in the differential diagnosis of the metabolic status of obese patients with non-insulin dependent diabetes mellitus
Authors: Dreval A. V. , Vysotsky V. G. , Yatsyshina T. A. , Plotnikova O. A. , Tishin D. P. , V. Anykina N. V. , Chernyak О. I.
Published: October 2019

Twenty-one obese patients with non-insulin dependent diabetes mellitus, 16 female and 5 male ones, were led similar isocaloric rations, differing only by the share of substitution of the traditional protein products (0 %, 60 %, 30 %, 45 %) in the Danpro-S, Danpro-Fibre soybean protein concentrate. The parameters tested were daily glycemia, C-peptides, blood hydrocortisone, and urinary excretion of nitrous metabolites. Indirect calorimetry was used to assess the protein, fat, and carbohydrate oxidation rates at rest. Addition of proteins of a plant origin to the diets of such patients was associated with significant changes of the energy metabolism at rest at the expense of increased oxidation of carbohydrates and reduced protein catabolism, that may be regarded as a favorable effect. In this patient population a 30 % soybean diet brings about an almost maximal positive effect in patients with the first degree of obesity, whereas in those with the second degree of obesity such effect is attained by the 45 % soybean diet.
A case of thyroid cancer dystopian to the root of the tongue
Authors: Choinzonov E. L. , Dubskii S. V.
Published: October 2019

The extreme variability of the shape and position of the thyroid gland is due to deviations in its embryonic development. Special studies have shown that in about half of cases, the remains of thyroid tissue are found in the region of the hyoid bone, the root of the tongue.
Activation of the sympathetic-adrenal system by the administration of corticoliberin in the caudate nucleus of dogs
Authors: Rakitskaya V. V. , Shalyapina V. G. , Voilokova N. L. , Suvorov N. F. , Turkina E. V.
Published: October 2019

Corticotrophin releasing factor injection into the head of the caudate nucleus of dogs was followed by a more than threefold increase of blood plasma adrenaline and noradrenaline levels as soon as in 30 min and . by their reduction by the 60th min after the injection though not to the initial values. These changes are compatible to stressor reaction and are associated with an increased orientation research reaction in animals. Injections of 6-hydroxydopamine into caudate nucleus drastically exhausted dopamine content in this structure. Subsequent injections of corticotrophin releasing factor into caudate nucleus virtually did not change blood plasma catecholamine content, this indicating the participation of the strionigral complex dopaminergic structures in realization of corticotrophin releasing factor effect on the sympathoadrenal system.
Differential diagnosis of generalized lipodystrophy syndrome
Authors: Letova Ye. K. , Starkova N. T.
Published: October 2019

The article is devoted to the description of the differential diagnosis of generalized lipodystrophy syndrome.
Postnatal outcomes of babies diagnosed with hydronephrosis in utero in a tertiary care centre in India over half a decade
Authors: Cherian Anne George , Jacob Tarun John K. , Sebastian Tunny , Vijayaselvi Reeta , David Liji Sarah , Kumar Manish , Beck Manisha Madhai
Published: October 2019

Background

Prenatal hydronephrosis is defined as the dilatation of the fetal renal pelvis and/or calyces and is the commonest anomaly detected in utero

Methods

This was a retrospective study to look at how well 148 antenatally detected cases of fetal hydronephrosis correlated with postnatal evaluation.

Results

Antenatal hydronephrosis was detected with a prevalence of 0.33%. The mean gestational age at diagnosis was 25.48 [standard deviation (SD) 6.36]. One hundred and sixteen (78.3%) fetuses had serial ultrasound scans during pregnancy to look for the progression of the condition. At the time of diagnosis, 30.1% of the fetuses were diagnosed to have mild hydronephrosis, 43.9% to have moderate hydronephrosis and 25.8% to have severe hydronephrosis. Follow-up ultrasounds during the prenatal period, 65% showed progression of the renal pelvis dilatation, 25.8% showed stable disease and 9.1% showed resolution on their subsequent scan. Almost half (46%) were found to have transient/physiological hydronephrosis. Thirty-one (20.9%) of the babies required an operation. An anteroposterior renal pelvis diameter (APD) of the fetal renal pelvis ≥17.5 mm can predict the need for surgery with a sensitivity of 70% and a specificity of 76.6%.

Conclusion

Counselling and decisions must be based on a series of ultrasound scans rather than a single evaluation. We use a cut-off of 17.5 mm as an indicator of possible postnatal surgical intervention.
Maternal Graves’ disease and fetal tetralogy of Fallot: a case series
Authors: Surendran Sushitha , Johnson Jason N.
Published: October 2019

Background

Congenital heart defects have been reported with the use of antithyroid medication with ventricular septal defects (VSD) being the most common. As per the current practice guidelines maternal Graves’ disease (GD) is not an indication for fetal echocardiogram.

Case presentation

We described three neonates with tetralogy of Fallot (TOF) born to mothers with GD. Only one of the mothers was on antithyroid medication. Two of these neonates were diagnosed postnatally when they failed the pulse oximeter congenital cardiac screening and diagnosis was established by postnatal echocardiogram. Two of the mothers had radioactive iodine ablation and were on levothyroxine during pregnancy. The dose of levothyroxine was increased during pregnancy. There was no other complication during pregnancy. The third mother had hyperthyroidism and developed a thyroid storm during pregnancy requiring inpatient admission and treatment with propylthiouracil (PTU), metoprolol and methimazole. All babies had normal thyroid function test postnatally and eventually had successful repair of TOF defect.

Conclusion

We report the largest known case series of children with TOF born to mothers with GD. Apart from the isolated reports of fetal TOF in mothers with GD, there is no clear association between fetal TOF and maternal GD and antithyroid medication. Based on the review of the literature and our case series, there may be an increased incidence of congenital heart defects in maternal GD irrespective of antithyroid medication use. This case series may add to the current knowledge base and support routine fetal echocardiogram screening for all mothers with GD.
Cognitive Flexibility Improves Memory for Delayed Intentions
Authors: Koslov Seth R. , Mukerji Arjun , Hedgpeth Katlyn R. , Lewis-Peacock Jarrod A.
Published: October 2019

The ability to delay the execution of a goal until the appropriate time, prospective memory (PM), can be supported by the following two different cognitive control strategies: proactive control involving working memory maintenance of the goal and active monitoring of the environment; or reactive control relying on timely retrieval of goal information from episodic memory. Certain situations tend to favor each strategy, but the manner in which individuals adjust their strategy in response to changes in the environment is unknown. Across two experiments, human participants performed a delayed-recognition PM task embedded in an ongoing visual search task that fluctuated in difficulty. A control strategy was identified from moment to moment using reaction time costs and fMRI measures of goal maintenance. We found that people fluidly modified control strategies in accordance with changes in task demands (e.g., shifting toward proactive control when task difficulty decreased). This cognitive flexibility proved adaptive as it was associated with improved PM performance.
Brigitte Adriaensen y Marco Kunz (Eds.). Narcoficciones en México y Colombia. Madrid/Frankfurt: Iberoamericana/Vervuert, 2016, 258 páginas
Authors: Chen Sham Jorge
Published: October 2019

Brigitte Adriaensen y Marco Kunz (Eds.). Narcoficciones en México y Colombia. Madrid/Frankfurt: Iberoamericana/Vervuert, 2016, 258 páginas
Preservation and study of old local forms of the so called “vineyard peach” (Prunus persica L.) in the Shumen region, Bulgaria
Authors: Vasilev D. , Malchev S. , Zhivondov A.
Published: October 2019

Abstract. During the period 2015-2017, scientific expeditions were conducted in the region of the town Shumen, located in the north-eastern part of Bulgaria, mainly around the village Madara where the concentration of natural forms derived from seedlings is the greatest. The purpose is to discover and research old local forms of the so called “vineyard peach” and to preserve them for possible future inclusion in breeding programmes to create new cultivars using more extended genepool. As a result, three forms of “vineyard peach” were selected from the local populations. The fruits of the three local forms are small and with primitive taste qualities but fit for human consumption. Two of the forms have white fruit flesh and one is with green. Two of the peach forms have vigorous growth, but one of the forms with white fruit flesh is of weak vigour. The three forms are spontaneous natural products obtained through long-term seed propagation. The trees are old but vital and without visual damage by diseases and pests, regularly bear fruits and have good annual growth despite competition from weeds, bushes and trees.
Influência dos distúrbios respiratórios no desenvolvimento das maloclusões
Authors: Figueredo Gabriela De Albuquerque Almeida , Feitosa Diana Maria Arraes , Gonçalves Ginna Kércia Matos , Alves Karla Shangela Da Silva
Published: October 2019

Objetivo: Investigar a relação entre maloclusões e desordens de ordem respiratória: rinite alérgica, hipertrofia de adenoide e de tonsilas palatinas em crianças.Material e Métodos: Realizou-se levantamento bibliográfico sobre o tema na base de dados PubMed, de 2007 a 2017, buscando artigos em inglês e português com as palavras-chave: maloclusão, odontopediatria, respiração bucal, adenoide, mordida cruzada, rinite alérgica, amídalas, em português e inglês. Foram incluídas as bibliografias que contivessem os descritores e, de exclusão, os que não atendessem à temática ou que não estivessem disponíveis na versão completa. Foi feita uma revisão da literatura, desenvolvida seguindo os preceitos de um estudo explanatório, por meio de pesquisa bibliográfica dividida em etapas. Muitos estudos mostraram que existe relação entre as desordens do trato respiratório superior (rinite alérgica, hipertrofia de adenoide e de amídalas) e alguns tipos de maloclusão.Conclusão: Ancorado nos achados bibliográficos, existe uma relação das desordens do trato respiratório e as maloclusões, por isso um acompanhamento multiprofissional é imprescindível, apontando relação direta entre prognóstico e precocidade no início do tratamento.