bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioactive peptides identification and nutritional status ameliorating properties on malnourished rats of combined eel and soy-based tempe flour
Authors: Sabrina Nindy , Rizal Mochammad , Nurkolis Fahrul , Hardinsyah Hardinsyah , Tanner Melvin Junior , Gunawan William Ben , Handoko Matthew Nathaniel , Mayulu Nelly , Taslim Nurpudji Astuti , Puspaningtyas Dwi Sari , Noor Sutamara Lasurdi , Yusuf Vincentius Mario , Permatasari Happy Kurnia , Radu Son
Published: September 2022

Background and aims

A combined eel and soy-based tempe (CEST) flour is rich in nutrients, especially its high amino acid content in which bioactive peptides (BPs) are expected to be found. Hence, this research aimed to identify the BPs of CEST flour and CEST supplementation’s effect on improving nutritional status biomarkers by ameliorating serum protein, hemoglobin, and IGF-1 of malnourished rats.

Methods

CEST flour with a ratio of eel and soy-based tempe of 1:3.5 was produced by applying the oven drying method. Amino acid sequences from six BPs were analyzed using a protein sequencer and spectrometer-electrospray ionization (MS-ESI). A total of thirty malnourished male Rattus norvegicus aged 3–4 weeks were given low-protein (LP; 4% w/w protein) diet treatment for 4 weeks. Afterward, rats were divided into 3 groups of 10 rats. Group A and B remained on a low-protein diet for 4 weeks, receiving an LP diet and getting doses of CEST of 100 and 200 mg/kg BW, respectively, via oral. Group C or control was given a Normal-protein (NP) diet (23% w/w of protein) and was allowed to feed ad libitum during the trial period without a dose of CEST.

Results

Six bioactive peptides were found, with WMGPY being the most abundant, along with a DPPH radical scavenging activity of 5.0 mg/mL. The results showed that serum protein, hemoglobin, and IGF-1 of group B were significantly higher compared to groups A and C (p = 0.0021). CEST dose of 200 mg/kg BW was more effective to increase serum levels of protein (p = 0.0052), hemoglobin, and IGF-1 (p < 0.0001) compared to a 100 mg/kg BW dose.

Conclusion

This indicates that the CEST flour has six bioactive peptides, which may contribute to the improvement of nutritional status biomarkers. To establish its potential impact, a human clinical study is urgently needed.
Case report: Alpelisib-induced Stevens–Johnson syndrome
Authors: Kurian Christine Jane , Desai Akshay , Rafferty William , Abou Hussein Ahmed Kamel
Published: September 2022

Background

Alpelisib is a recently approved treatment for hormone receptor-positive, HER2-negative, PIK3CA-mutated advanced breast cancer. It has been associated with alopecia and rash, but there are no documented cases of Stevens–Johnson Syndrome (SJS) associated with this drug. Here, we detail the first case of SJS associated with alpelisib.

Case description

Our patient is a 60-year-old woman with a past medical history of metastatic hormone receptor-positive (ER+ 80% and PR+ 1%), HER2-negative metastatic breast cancer who presented with acute odynophagia, fevers, and diffuse body rash after receiving her first doses of alpelisib and fulvestrant in the preceding days. She presented to the emergency department after developing a whole-body rash and severe ulceration of her buccal mucosa. She was started on methylprednisolone with remarkable improvement in symptoms.

Conclusion

This case report details the only report of SJS following alpelisib treatment. Immediate cessation of drugs and initiation of steroids are the cornerstone of treatment. Patients who experience such side effects will have to be monitored closely for long-term sequelae associated with SJS, including cutaneous, ocular, and oral sequelae, all of which can profoundly affect the quality of life for cancer patients.
Association of perioperative adverse events with subsequent therapy and overall survival in patients with WHO grade III and IV gliomas
Authors: Weber Lorenz , Padevit Luis , Müller Timothy , Velz Julia , Vasella Flavio , Voglis Stefanos , Gramatzki Dorothee , Weller Michael , Regli Luca , Sarnthein Johannes , Neidert Marian Christoph
Published: September 2022

Background

Maximum safe resection followed by chemoradiotherapy as current standard of care for WHO grade III and IV gliomas can be influenced by the occurrence of perioperative adverse events (AE). The aim of this study was to determine the association of AE with the timing and choice of subsequent treatments as well as with overall survival (OS).

Methods

Prospectively collected data of 283 adult patients undergoing surgery for WHO grade III and IV gliomas at the University Hospital Zurich between January 2013 and June 2017 were analyzed. We assessed basic patient characteristics, KPS, extent of resection, and WHO grade, and we classified AE as well as modality, timing of subsequent treatment (delay, interruption, or non-initiation), and OS.

Results

In 117 patients (41%), an AE was documented between surgery and the 3-month follow-up. There was a significant association of AE with an increased time to initiation of subsequent therapy (p = 0.005) and a higher rate of interruption (p < 0.001) or non-initiation (p < 0.001). AE grades correlated with time to initiation of subsequent therapy (p = 0.038). AEs were associated with shorter OS in univariate analysis (p < 0.001).

Conclusion

AEs are associated with delayed and/or altered subsequent therapy and can therefore limit OS. These data emphasize the importance of safety within the maximum-safe-resection concept.
The impact of music-imaginative pain treatment (MIPT) on psychophysical affect regulation – A single case study
Authors: Glomb Sina , Böckelmann Irina , Frommer Jörg , Metzner Susanne
Published: September 2022

Music-imaginative Pain Treatment (MIPT) is part of the multi-professional treatment plan for hospitalised patients in departments for psychosomatic medicine. MIPT is an intervention that encourages the patient to create music representing pain and relief from pain and promotes active engagement and self-reflection. This single case study of a 46-year-old female patient diagnosed with chronic pain disorder with somatic and psychological factors includes narrative, demographic, psychometric, and cardiophysiological data. During the interventions, early childhood stress, which is a risk factor for developing chronic pain, turns out to be a crucial focal point in therapy and conspicuous in her handling of the music. Social trauma is considered an appropriate concept for a deeper understanding of the case.
Administrative data in pediatric critical care research—Potential, challenges, and future directions
Authors: Bruns Nora , Sorg Anna-Lisa , Felderhoff-Müser Ursula , Dohna-Schwake Christian , Stang Andreas
Published: September 2022

Heterogenous patient populations with small case numbers constitute a relevant barrier to research in pediatric critical care. Prospective studies bring along logistic barriers and—if interventional—ethical concerns. Therefore, retrospective observational investigations, mainly multicenter studies or analyses of registry data, prevail in the field of pediatric critical care research. Administrative health care data represent a possible alternative to overcome small case numbers and logistic barriers. However, their current use is limited by a lack of knowledge among clinicians about the availability and characteristics of these data sets, along with required expertise in the handling of large data sets. Specifically in the field of critical care research, difficulties to assess the severity of the acute disease and estimate organ dysfunction and outcomes pose additional challenges. In contrast, trauma research has shown that classification of injury severity from administrative data can be achieved and chronic disease scores have been developed for pediatric patients, nurturing confidence that the remaining obstacles can be overcome. Despite the undoubted challenges, interdisciplinary collaboration between clinicians and methodologic experts have resulted in impactful publications from across the world. Efforts to enable the estimation of organ dysfunction and measure outcomes after critical illness are the most urgent tasks to promote the use of administrative data in critical care. Clever analysis and linking of different administrative health care data sets carry the potential to advance observational research in pediatric critical care and ultimately improve clinical care for critically ill children.
Safety and efficacy of p38 mitogen-activated protein kinase inhibitors (MAPKIs) in COPD
Authors: Yu Haichuan , Su Xiaojie , Lei Ting , Zhang Lu , Feng Zhouzhou , Zhang Chuchu , Zhang Meng , Wang Yalei , Chen Xinlong , Liu Jian
Published: September 2022

Introduction: Chronic inflammation is the core mechanism of the development of chronic obstructive pulmonary disease (COPD). Corticosteroid resistance in COPD limits its anti-inflammatory potency. p38 MAPKIs were suggested as an alternative to corticosteroids despite the fact that there is currently no systematic review evaluating existing evidence.

Methods: This randomized controlled trials (RCT)-based systematic review with meta-analysis was conducted following the PRISMA statement. RCTs were searched and screened from 8 databases. Three types of data, including basic information of included studies, pre-defined outcome data, and quality assessment information were extracted. Pooling values and associated 95 % confidence intervals were deemed as statistically significant only when two-tailed p values were smaller than 0.05.

Results: This study included 10 RCTs with a total population of 1,751 [age, mean (SD) = 64.39 (8.06)]. Safety and several efficacy indicators of lung function, inflammatory biomarkers, and quality of life were meta-analyzed. Despite the improvement of post-bronchodilator-forced vital capacity (FVC), no difference between p38 MAPKIs and placebo was found in both safety and efficacy.

Conclusion: Compared with placebo, p38 MAPKIs are safe but did not show any significant effects in the COPD population. Results of this study should be regarded with caution due to the small number of included studies and heterogeneity from combining different p38 MAPKIs as a whole.

Systematic Review registration: PROSPERO #CRD42022302890.
Acute, chronic, and genotoxic studies on the protopine total alkaloids of the Macleaya cordata (willd.) R. Br. in rodents
Authors: Dong Zhen , Tang Shu-sheng , Ma Xiao-lan , Tan Bin , Tang Zhao-shan , Li Chang-hong , Yang Zi-hui , Zeng Jian-guo
Published: September 2022

The protopine alkaloids are widely distributed within the opium poppy family and have a wide range of pharmacological effects. MPTA is a product of the protopine total alkaloids extracted from the Macleaya cordata (Willd.) R. Br. Previously, we reported good anti-inflammatory activity of MPTA as well as oral acute and sub-chronic toxicity studies in rats. In order to perform a systematic toxicological safety assessment of MPTA, oral acute toxicity, genotoxicity (bone marrow cell chromosome aberration test, sperm abnormality test, bone marrow cell micronucleus test, and rat teratogenicity test), and chronic toxicity in mice were performed in this study. In the oral acute toxicity test, the LD50 in ICR mice was 481.99 mg/kg, with 95% confidence limits ranging from 404.27 to 574.70 mg/kg. All three mutagenicity tests tested negative in the range of 60.25–241.00 mg/kg. The results of the teratogenicity test in rats showed no reproductive or embryonic developmental toxicity at only 7.53 mg/kg, which can be considered as a no observed effect level (NOEL) for the teratogenicity test. Therefore, MPTA is safe for use at the doses tested, but attention should be paid to the potential risk to pregnant animals and the safety evaluation and toxicity mechanisms in target animals should be further investigated.
Integrated metabolomic and transcriptomic analyses reveal different metabolite biosynthesis profiles of Juglans mandshurica in shade
Authors: Zhang Xinxin , Li Yuxi , Yan Huiling , Cai Kewei , Li Hanxi , Wu Zhiwei , Wu Jianguo , Yang Xiangdong , Jiang Haichen , Wang Qingcheng , Qu Guanzheng , Zhao Xiyang
Published: September 2022

Light is not only a very important source of energy for the normal growth and development of plants, but also a regulator of many development and metabolic processes. The mechanism of plant growth and development under low light conditions is an important scientific question. With the promulgation of the law to stop natural forest cutting, understory regeneration is an important method for artificial forest afforestation. Here, the growth and physiological indexes of Juglans mandshurica, an important hardwood species in Northeast China, were measured under different shade treatments. In addition, transcriptome and metabolome were compared to analyze the molecular mechanism of shade tolerance in J. mandshurica. The results showed that the seedling height of the shade treatment group was significantly higher than that of the control group, and the 50% light (L50) treatment was the highest. Compared with the control group, the contents of gibberellin, abscisic acid, brassinolide, chlorophyll a, and chlorophyll b in all shade treatments were significantly higher. However, the net photosynthetic rate and water use efficiency decreased with increasing shade. Furthermore, the transcriptome identified thousands of differentially expressed genes in three samples. Using enrichment analysis, we found that most of the differentially expressed genes were enriched in photosynthesis, plant hormone signal transduction and chlorophyll synthesis pathways, and the expression levels of many genes encoding transcription factors were also changed. In addition, analysis of differentially accumulated metabolites showed that a total of 470 differential metabolites were identified, and flavonoids were the major differential metabolites of J. mandshurica under light stress. These results improved our understanding of the molecular mechanism and metabolite accumulation under light stress in J. mandshurica.
Somatic embryogenesis and plant regeneration from transverse thin cell layers of adult peach palm (Bactris gasipaes) lateral offshoots
Authors: Campos-Boza Stefanny , Vinas María , Solórzano-Cascante Paul , Holst Andrea , Steinmacher Douglas A. , Guerra Miguel P. , Jiménez Víctor M.
Published: September 2022

In this work, we report a successful protocol to obtain in vitro peach palm (Bactris gasipaes Kunth) “Diamantes 10” plants through somatic embryogenesis from transverse thin cell layer (TCL) explants, dissected from three sections (basal, medial, and apical) of lateral offshoots of adult plants cultured on different concentrations of 4-amino-3,5,6-trichloropicolonic acid (picloram). After swelling and development of primary callus in all treatments, without any strong effect of explant origin or picloram concentration, it was possible to observe the formation of embryogenic structures and the exact point from where they developed. Browning was also observed and correlated to the induction treatments, although it was not an impairment for the production of embryogenic structures. Subsequent maturation and conversion of somatic embryos into plantlets allowed their acclimatization 17 months after culture initiation (ACI), which was quicker than previous reports with juvenile tissues (from embryos or seed-germinated plantlets). To the best of our knowledge, this is the first report on peach palm regeneration through somatic embryogenesis from TCL explants from adult plants and could constitute, after fine-tuning the acclimatization stage, a tool for mass clonal propagation of elite genotypes of this open-pollinated crop, as well as for the establishment of conservation strategies of in situ gene bank plant accessions endangered due to aging and other threats.
Language impairments in children with developmental language disorder and children with high-functioning autism plus language impairment: Evidence from Chinese negative sentences
Authors: Dai Huilin , He Xiaowei , Chen Lijun , Yin Chan
Published: September 2022

There is controversy as to whether children with developmental language disorder (DLD) and those with high-functioning autism plus language impairment (HFA-LI) share similar language profiles. This study investigated the similarities and differences in the production of Chinese negative sentences by children with DLD and children with HFA-LI to provide evidence relevant to this controversy. The results reflect a general resemblance between the two groups in their lower-than-TDA (typically developing age-matched) performance. Both groups encountered difficulties in using negative markers, which suggests that they might be impaired in feature agreement. Slight differences were detected between the two groups. Specifically, children with DLD experienced difficulties with the agreement on the feature [+telic] and that on the feature [+dynamic], while children with HFA-LI had difficulties with the agreement on the feature [+dynamic] and that on the feature [−dynamic]. This study supports the idea of a common symptomatology for the two disorders. More importantly, it suggests that these two disorders, DLD and HFA-LI, are not altogether the same in terms of language impairment. This paper concludes that general labels should not be simply attached to any children with language disorders. Instead, atypical language is very worthy of further analysis in the categorization of language disorders.
Trainability of novel person recognition based on brief exposure to form and motion cues
Authors: Steel Kylie Ann , Robbins Rachel A. , Nijhuis Patti
Published: September 2022

Fast and accurate recognition of teammates is crucial in contexts as varied as fast-moving sports, the military, and law enforcement engagements; misrecognition can result in lost scoring opportunities in sport or friendly fire in combat contexts. Initial studies on teammate recognition in sport suggests that athletes are adept at this perceptual ability but still susceptible to errors. The purpose of the current proof-of-concept study was to explore the trainability of teammate recognition from very brief exposure to vision of the whole-body form and motion of a previously unknown individual. Participants were divided into three groups: a 4-week training group who were also the actors for the test and training footage, a 2-week training group, and a no-training group. Findings revealed significant differences between the training groups and their improvement from the pre-to post-test on Response Accuracy and Movement Time. The current study found the best performance in the 4-week Training group. The biggest improvement was found in the 2-week training group, whilst no significant improvement was made in the Control group. These results suggest that training was effective, but also indicate that having initially performed the movements as actors may have led to improvements in baseline testing and ultimately the best results, thus physical performance of skills combined with video-based training may reduce the amount of time needed to improve teammate identification.
A data-driven, hyper-realistic method for visualizing individual mental representations of faces
Authors: Albohn Daniel N. , Uddenberg Stefan , Todorov Alexander
Published: September 2022

Research in person and face perception has broadly focused on group-level consensus that individuals hold when making judgments of others (e.g., “X type of face looks trustworthy”). However, a growing body of research demonstrates that individual variation is larger than shared, stimulus-level variation for many social trait judgments. Despite this insight, little research to date has focused on building and explaining individual models of face perception. Studies and methodologies that have examined individual models are limited in what visualizations they can reliably produce to either noisy and blurry or computer avatar representations. Methods that produce low-fidelity visual representations inhibit generalizability by being clearly computer manipulated and produced. In the present work, we introduce a novel paradigm to visualize individual models of face judgments by leveraging state-of-the-art computer vision methods. Our proposed method can produce a set of photorealistic face images that correspond to an individual's mental representation of a specific attribute across a variety of attribute intensities. We provide a proof-of-concept study which examines perceived trustworthiness/untrustworthiness and masculinity/femininity. We close with a discussion of future work to substantiate our proposed method.
Design and realization of a novel haptic graspable interface for augmenting touch sensations
Authors: Pediredla Vijay Kumar , Chandrasekaran Karthik , Annamraju Srikar , Thondiyath Asokan
Published: September 2022

A novel haptic grasper that renders touch sensations to the user in 3-DoF (degrees of freedom), namely linear, rotary, and grasping motions, is presented. The touch sensations of the grasper include the combination of kinesthetic and tactile modalities such as stiffness, texture, and shape. The device is equipped with two swappable modular segments that provide stiffness and shape sensations. To increase the haptic fidelity, the textural surfaces that surround the outer surface of the segments are equipped with vibro-actuators underneath them. These vibro-actuators contribute to increasing the number of perceivable textures by varying amplitude, frequency, duration, and envelope of vibrations. The proposed device is characterized in terms of stiffness, shape and texture rendering capabilities. The experimental results validate the effectiveness of the developed haptic grasper in virtual/remote interactions. Also, the user studies and statistical analysis demonstrate that the users could perceive the high-fidelity haptic feedback with the unified sensations of kinesthetic and tactile cues.
Materials and modes of translation: Re-imagining inclusive “zero”-waste futures
Authors: van den Eijnden Tamalone , Baibarac-Duignan Corelia , de Lange Michiel , de Goede Maartje
Published: September 2022

In this paper, we present and reflect upon a creative and participatory approach for engaging citizens in imagining desirable “zero”-waste futures that include different values and perspectives. The approach emerged through a 4-month collaboration involving academic researchers and creative professionals and was prototyped in a formerly industrial neighborhood of Utrecht (het Werkspoorkwartier), currently being developed as a creative circular manufacturing area. With our approach, we inquire into and provide an alternative to predominant technology-centered policy visions, which portray the issues of waste as objective challenges that can be addressed through data-driven technological solutions. Such visions neglect many other perspectives and values, particularly those of citizens that face the issue of waste in everyday life, thus providing only a narrow vision of how the future might look like. To gather and articulate different perspectives on alternative “zero”-waste futures, we focus on citizen-science-inspired and speculative design methods to engage people and stimulate imagining futures that bring to light diverse values and perspectives. In the development of the methods, we work in close collaboration with creative practitioners, both in terms of anchoring the research in a real-world context and in terms of combining our different types of expertise. Reflecting on the project, we discuss the potential of our transdisciplinary approach and the co-produced methods to intervene in how we see and imagine alternative futures. We do so by taking “translation” as an analytical lens to understand how different meanings and visions are created through experiential, material, and affective modes of expression. Specifically, we will analyze the translations that occur in the processes of moving from abstract data to matters of concern, and from desirable futures to actionable presents. Looking at these multiple processes through the lens of translation will serve to investigate how different future imaginaries are generated through different materials and modalities of translation, offering different forms of engagement in shaping inclusive urban futures. Translation here will be conceptualized less as a perfect transference of information and more as an open-ended process of paying attention to different values, and identifying those matters for which to care for in our urban futures.
Double Tisserand graphs for low-energy lunar transfer design
Authors: Martens Waldemar , Bucci Lorenzo
Published: September 2022

Tisserand graphs are a widespread tool for interplanetary trajectory and Moon tour design. They are based on the Jacobi constant being an integral of motion in the Circular Restricted Three Body Problem (CR3BP); as such, the classical Tisserand graph does not include the perturbation of bodies other than the flyby bodies. Low-energy transfers in the Earth-Moon system make use of the combined Earth, Moon, and Sun gravities, exploiting the third body perturbations to reach the Moon with a reduced transfer Δv. The paper, therefore, proposes a novel double Tisserand graph, where the level lines of both the Earth-Moon and the Sun-Earth CR3BPs are superimposed, portraying the complex 4-body dynamics into a single plot. Paths along such level lines correspond to trajectories utilizing the dynamical effect of the Moon or the Sun or a combination of both. We show how such a graph can be efficiently used for preliminary design of Weak Stability Boundary transfers, lunar resonance transfers, lunar flybys, weak lunar captures or any combination of them.
Impacts of microplastics on immunity
Authors: Yang Wenjie , Jannatun Nahar , Zeng Yanqiao , Liu Tinghao , Zhang Guofang , Chen Chunying , Li Yang
Published: September 2022

Most disposable plastic products are degraded slowly in the natural environment and continually turned to microplastics (MPs) and nanoplastics (NPs), posing additional environmental hazards. The toxicological assessment of MPs for marine organisms and mammals has been reported. Thus, there is an urgent need to be aware of the harm of MPs to the human immune system and more studies about immunological assessments. This review focuses on how MPs are produced and how they may interact with the environment and our body, particularly their immune responses and immunotoxicity. MPs can be taken up by cells, thus disrupting the intracellular signaling pathways, altering the immune homeostasis and finally causing damage to tissues and organs. The generation of reactive oxygen species is the mainly toxicological mechanisms after MP exposure, which may further induce the production of danger-associated molecular patterns (DAMPs) and associate with the processes of toll-like receptors (TLRs) disruption, cytokine production, and inflammatory responses in immune cells. MPs effectively interact with cell membranes or intracellular proteins to form a protein-corona, and combine with external pollutants, chemicals, and pathogens to induce greater toxicity and strong adverse effects. A comprehensive research on the immunotoxicity effects and mechanisms of MPs, including various chemical compositions, shapes, sizes, combined exposure and concentrations, is worth to be studied. Therefore, it is urgently needed to further elucidate the immunological hazards and risks of humans that exposed to MPs.
Estimating Tail Probabilities of Random Sums of Phase-Type Scale Mixture Random Variables
Authors: Yao Hui , Taimre Thomas
Published: September 2022

We consider the problem of estimating tail probabilities of random sums of scale mixture of phase-type distributions—a class of distributions corresponding to random variables which can be represented as a product of a non-negative but otherwise arbitrary random variable with a phase-type random variable. Our motivation arises from applications in risk, queueing problems for estimating ruin probabilities, and waiting time distributions, respectively. Mixtures of distributions are flexible models and can be exploited in modelling non-life insurance loss amounts. Classical rare-event simulation algorithms cannot be implemented in this setting because these methods typically rely on the availability of the cumulative distribution function or the moment generating function, but these are difficult to compute or are not even available for the class of scale mixture of phase-type distributions. The contributions of this paper are that we address these issues by proposing alternative simulation methods for estimating tail probabilities of random sums of scale mixture of phase-type distributions which combine importance sampling and conditional Monte Carlo methods, showing the efficiency of the proposed estimators for a wide class of scaling distributions, and validating the empirical performance of the suggested methods via numerical experimentation.
Lysosomes and Their Role in Regulating the Metabolism of Hematopoietic Stem Cells
Authors: Arif Tasleem
Published: September 2022

Hematopoietic stem cells (HSCs) have the capacity to renew blood cells at all stages of life and are largely quiescent at a steady state. It is essential to understand the processes that govern quiescence in HSCs to enhance bone marrow transplantation. It is hypothesized that in their quiescent state, HSCs primarily use glycolysis for energy production rather than mitochondrial oxidative phosphorylation (OXPHOS). In addition, the HSC switch from quiescence to activation occurs along a continuous developmental path that is driven by metabolism. Specifying the metabolic regulation pathway of HSC quiescence will provide insights into HSC homeostasis for therapeutic application. Therefore, understanding the metabolic demands of HSCs at a steady state is key to developing innovative hematological therapeutics. Lysosomes are the major degradative organelle in eukaryotic cells. Catabolic, anabolic, and lysosomal function abnormalities are connected to an expanding list of diseases. In recent years, lysosomes have emerged as control centers of cellular metabolism, particularly in HSC quiescence, and essential regulators of cell signaling have been found on the lysosomal membrane. In addition to autophagic processes, lysosomal activities have been shown to be crucial in sustaining quiescence by restricting HSCs access to a nutritional reserve essential for their activation into the cell cycle. Lysosomal activity may preserve HSC quiescence by altering glycolysis-mitochondrial biogenesis. The understanding of HSC metabolism has significantly expanded over the decade, revealing previously unknown requirements of HSCs in both their dividing (active) and quiescent states. Therefore, understanding the role of lysosomes in HSCs will allow for the development of innovative treatment methods based on HSCs to fight clonal hematopoiesis and HSC aging.
Promoting Sexuality Education for Children and Adolescents on a Large Scale: Program Design, Organizational Cooperation Network and Administrative Mobilization
Authors: Dong Huina , Li Hongyan
Published: September 2022

In China, the promotion of sexuality education for children and adolescents is hindered by a relatively conservative culture and insufficient drive from the government. With the government and the market failing to deliver in this area, social organizations, such as the third sector, are playing an important role. This paper mainly discusses how Chinese social organizations promote sexuality education for children and adolescents on a large scale. This paper studied NW, the largest sexuality education support platform in China at present, and 16 frontline implementing organizations in its cooperation network. This research collects empirical data through participatory observation and semi-structured interviews, involving a total of 37 interviewees, plus relevant text data. The study follows the analytical method of process tracking, trying to extract the key mechanisms of how social organizations promote sexuality education from the processes demonstrated by the specific cases. This paper focuses on the key phases of a standardized sexuality education program, from its design to promotion and then to implementation. It is found that, based on the large-scale operation strategy, the operation process of the sexuality education program exhibited three core mechanisms: standardized program design, organizational cooperation network and administrative mobilization. These three mechanisms have become the key force to break through many of the cultural and institutional obstacles and achieve large-scale implementation of sexuality education. Finally, this paper discusses the challenges of operationalizing the sexuality education program, with compromised teaching quality as a major one, and points to the direction for future research.
A Novel Ferroptosis-Related Signature for Prediction of Prognosis, Immune Profiles and Drug Sensitivity in Hepatocellular Carcinoma Patients
Authors: Zhao Chuanbing , Zhang Zhengle , Tao Jing
Published: September 2022

Hepatocellular carcinoma (HCC) is a malignant disease with an increasing incidence and a high mortality rate. Ferroptosis, a novel type of cell death, has been reported to be closely associated with the progression of HCC. The aim of our study was to construct a novel ferroptosis-related signature (nFRGs) for prediction of prognosis, immune features and drug sensitivity of HCC patients. Data were obtained from the TCGA, ICGC, GSE104580, CCLE and IMvigor210 datasets, and the least absolute shrinkage and selection operator (LASSO) was used to construct nFRGs. In addition, the analyses involved in prognoses, molecular function, stemness indices, somatic mutation, responses to immunologic therapy, efficacy of transcatheter arterial chemoembolization (TACE) therapy and drug sensitivity were performed using diverse packages of R 4.1.3 between the low- and high-risk groups. The nFRGs included seven ferroptosis-related genes. Our results showed that nFRGs was an independent risk factor for prognoses of HCC patients, and HCC patients in the high-risk group presented with worse prognosis. Compared with the results of other studies, nFRGs was superior to other promising signatures in predicting prognoses of patients with HCC. In addition, most of the enriched pathways of differentially expressed genes (DEGs) between these subgroups were related to immune features. The molecular functions, genetic mutation and mRNAsi were varied between the high- and low-risk groups. Moreover, we observed significant immunosuppression state in the high-risk group. Patients in the high-risk group might benefit from immunotherapy, whereas patients in the low-risk group may be susceptible to TACE therapy. Finally, five sensitive drugs and four sensitive drugs were screened for patients in the high- and low-risk groups, respectively. nFRGs may served as a novel biomarker of prognosis and aid in personalized therapeutic strategies for patients with HCC.
Transport of Geothermal Fluids along Dikes and Fault Zones
Authors: Gudmundsson Agust
Published: September 2022

Field observations of active and fossil natural geothermal fields indicate that geothermal fluids are primarily transported along dikes and fault zones. Fluid transport along dikes (commonly through fractures at their margins) is controlled by the cubic law where the volumetric flow rate depends on the aperture of the fracture in the 3rd power. Dikes (and inclined sheets) also act as heat sources for geothermal fields. In high-temperature fields in volcanoes in Iceland dikes and inclined sheets constitute 80–100% of the rock at crustal depths of 1.5–2 km. Holocene feeder-dikes are known to have increased the activity of associated geothermal fields. Fault zones transport geothermal fluids along their two main hydromechanical units, the core and the damage zone. The core is comparatively thin and primarily composed of breccia, gouge, and clay and related low-permeability porous materials. By contrast, the fault damage zone is characterised by fractures whose frequency is normally highest at the contact between the core and the damage zone. Fluid transport in the damage zone, and in the core following fault slip, is controlled by the cubic law. During non-slip periods fluid transport in the core is primarily controlled by Darcy’s law. Secondary mineralisation (forming mineral veins and amygdales) tends to reduce the fault-zone permeability. Repeated earthquake activity is thus needed to maintain the permeability of fault zones in active natural geothermal fields.
Dynamic Changes in Soil Phosphorus Accumulation and Bioavailability in Phosphorus-Contaminated Protected Fields
Authors: Liang Hongyue , Wang Chen , Lu Xinrui , Sai Chunmei , Liang Yunjiang
Published: September 2022

Soil phosphorus accumulation resulting in a high risk of phosphorus pollution is due to high multiple vegetable cropping indexes and excessive fertilizer input in protected fields. Therefore, this study explored the bioavailability of soil-accumulated phosphorus to improve fertilization and reduce the risk of soil phosphorus contamination in protected fields. A field trial was performed in Yanbian Prefecture, China to study the phosphorus bioavailability after continuous spinach planting without phosphate fertilizer applications. Results indicated that with increasing numbers of planting stubbles, soil inorganic phosphorus and occluded phosphorus changed little, while water-soluble and loose phosphorus, aluminum-phosphate, iron-phosphate, and calcium-phosphorus decreased first and then increased. Soil available phosphorus declined linearly. For planting spinach in protected fields, the threshold of soil phosphorus deficiency is 200 mg kg−1. A soil phosphorus supply potential model was established between x (the soil available phosphorus) and y (the numbers of planting stubbles): y = 6.759 + 0.027x, R = 0.99, which can be used to predict how planting stubbles are needed to raise the soil available phosphorus above the critical value of phosphorus deficiency for spinach. These results will provide the theoretical guidance for rational phosphorus fertilizer applications and control agricultural, non-point pollution sources in protected fields.
What Would ‘Indianness’ of New Testament Theology Mean? Congregation for the Doctrine of the Faith on Anthony De Mello, ‘Via Negativa’ and beyond the Accepted Routes in Catholic Theology
Authors: Fárek Martin
Published: September 2022

This article focuses on one specific theological controversy, which pertains to the kataphatic—apophatic debates as a framework for New Testament theology. In the year 1998, theologians from Congregation for the Doctrine of the Faith issued a refutation of teaching of Anthony De Mello, SJ. The analysis of the Congregation’s refutation and the consequent debate led to the following hypothesis: Although the teaching of De Mello can be understood as following the apophatic line of thought in Christology and other important topics of New Testament theology, it is also bringing several distinctly Indian ideas and emphasis into the debate. Whereas apophatic theology is concerned with the problem of intellectual knowledge about God, the Indian view is concerned with the question of practical role of language in human attempts to experience the Divine. In both approaches, debates about the role of human thought, as expressed in language, are crucial, but for different reasons and with different aims.
Eficácia da acupuntura em pacientes com retinose pigmentar: série de casos
Authors: Teixeira Maria do Socorro Uchôa Monteiro , Saldanha Larissa Silves , Meireles Lincoln Tavares , Cardoso Ana Richelly Nunes Rocha , De Carvaho Alyne Mara Rodrigues , Vasconcelos Thiago Brasileiro de , Vasconcelos Leonardo Freire
Published: September 2022

Introdução. A Retinose Pigmentar (RP) refere-se a um grupo de doenças hereditárias que causam a degeneração da retina. É uma condição ocular que consiste em um declínio gradual na visão pela diminuição da função das células fotorreceptoras, são elas os cones e bastonetes. Na RP a degeneração inicia-se pelos bastonetes responsáveis pela visão noturna e periférica, seguindo a degeneração dos cones responsável pela visão diurna e cores. Objetivo. Avaliar o efeito da técnica de acupuntura no tratamento de pacientes com retinose pigmentar para melhora do campo visual e qualidade de vida. Método. Trata-se de um estudo descritivo, realizado com três indivíduos na Clínica Ômega Store Nutrition, Fortaleza, no período de agosto a outubro de 2019. Os atendimentos aconteceram 3 vezes por semana, cada sessão durava 40 minutos seguindo o mesmo protocolo de atendimento o qual consiste na aplicação de pontos padrões para visão que estão localizados ao redor dos olhos, cabeça, orelhas, mãos, braços, pernas e pés, além da utilização do dispositivo de eletroacupuntura. Resultados. Segundo os dados obtidos nos exames oftalmológicos, como campo visual realizado através da escala de Snellen, Fundoscopia, para examinar as condições do seguimento posterior do olho, das artérias, veias e nervos da retina, e da campimetria visual computadorizada através dos indicadores de Sensibilidade média (MS) e Defeito Médio (MD), todas as participantes obtiveram melhoras mensuráveis na evolução do campo visual. Conclusão. Os resultados foram promissores e constataram a eficácia do tratamento de acupuntura para melhora do campo visual.
Efetividade da interface MESS-FESS na dorsiflexão de tornozelo após AVC por cavernoma: estudo de caso
Authors: Fontana Pereira Nathalia , Campanini Alvares Eduarda , Pinto Guedes Fernando , Prado Campos Daniel , Burgo de Souza Roger , Krueger Eddy
Published: September 2022

Introdução. O sangramento causado pelo cavernoma pode levar a déficits focais, afetando a articulação do tornozelo, dificultando a dorsiflexão, atividades funcionais decorrentes deste movimento e o desenvolvimento da marcha. A plataforma baropodométrica permite a visualização de variáveis oriundas do tornozelo. Objetivo. Verificar a efetividade da interface MESs-FESs associada a exercícios de reabilitação neurofuncional sobre a dorsiflexão de tornozelo e execução da marcha em um indivíduo após sangramento intraparenquimatoso por cavernoma. Método. Estudo de caso com uma participante avaliada por meio da (i) escala modificada de Ashworth, (ii) goniometria, (iii) eletromiografia de superfície (os dados foram normalizados) e (iv) baropodometria estática e dinâmica. A intervenção foi realizada em 6 sessões com duração de 30 minutos, onde a interface MESs-FESs era associada a exercícios de reabilitação. Resultados. O músculo tibial anterior não obteve aumento no seu valor eficaz (EMGRMS), porém, o músculo gastrocnêmio medial apresentou uma redução no EMGRMS de 55% durante a marcha, levando a um aumento de 30% da ADM, na baropodometria detectou-se maior simetria nas respostas plantares durante o ortostatismo, durante a marcha houve melhora no posicionamento do calcanhar, durante o contato inicial, e aplainamento do pé com subsequente maior tempo de apoio no membro acometido. Adicionalmente, foi observado melhora na mobilidade de tornozelo. Conclusão. A associação da interface MESs-FESs com exercícios de reabilitação mostrou ser efetiva como instrumento de auxílio no tratamento de sequelas de paresia do tornozelo. Sendo uma ferramenta viável e segura para inserção no ambiente clínico.
Quebrada de La Cueva (Humahuaca, Jujuy, Argentina): prácticas agrícolas prehispánicas en su contexto espacial y temporal
Authors: Ramundo Paola Silvia
Published: September 2022

En esta investigación se analiza el panorama agrícola prehispánico de la quebrada de La Cueva (departamento de Humahuaca, Jujuy) en el contexto del Sector Norte de la Quebrada de Humahuaca. El estudio realizado establece la división de la quebrada de La Cueva en tres sectores (Inferior, Medio y Superior) con diferencias en la variada evidencia de este tipo de producción (cuadros o canchones de diversos tamaños y formas, andenes, terrazas, acequias, silos y despedres). También se demuestra que la ubicación estratégica de la quebrada habría facilitado la agricultura, la cual se desarrolló –al menos– desde el período Formativo Final hasta el período Incaico para el consumo local y, eventualmente, el consumo en sectores cercanos y lejanos a la misma. Aunque la intensidad de la práctica no sea idéntica a la determinada en otros espacios agrícolas del Sector Norte de la Quebrada de Humahuaca (por ejemplo, Coctaca, Rodero, Chaupi Rodeo, entre otros), sí fue importante y diversa.
¿Cómo pensamos y representamos a los grupos humanos de la región Pampeana (Argentina)? Un análisis del discurso arqueológico
Authors: Elichiry Valeria , Arislur Selene
Published: September 2022

Entendemos a la arqueología como una de las principales disciplinas que produce imaginarios sociales sobre el pasado. Por ello, en este trabajo analizamos las representaciones sobre los grupos humanos construidas desde el discurso arqueológico en la región pampeana mediante una revisión bibliográfica de 290 publicaciones. Registramos las áreas de estudio y temporalidades en relación con categorías utilizadas para referirse a las personas, menciones sexo-genéricas, a grupos de edad, sobre alimentación, prácticas de caza y recolección. Reflexionamos sobre sus implicancias en torno a dimensiones como la complejidad de los grupos humanos, la diversidad y las relaciones pasado-presente. Observamos que el 60% de los trabajos utiliza la categoría cazadores recolectores, independientemente de la temporalidad y el área estudiada, mientras que un 10% no alude a personas. Además, registramos un uso recurrente y acotado de términos, vinculados con adscripciones temporales, para referirse a las personas en los períodos más antiguos, en contraste con una mayor diversidad terminológica para el Holoceno tardío y Postconquista. En general, se presentan paquetes temporo-espaciales para denominar a los grupos que contribuye a una ruptura entre pasado y presente. También, encontramos que las temáticas trabajadas aportan a pensar en la complejidad de los grupos, pero diluyen la diversidad. La activación de sentidos sobre el pasado humano moviliza procesos en el presente que potencian o limitan el reconocimiento de la existencia de la diversidad y desigualdad social. Aquí buscamos reflexionar sobre la forma de conocer que habilita (o restringe) el discurso arqueológico.
Análisis zooarqueológico del sitio Álvarez 4 (noroeste de Patagonia, Argentina). Un aporte al estudio de la subsistencia de los grupos humanos de la cuenca media del río Limay durante el Holoceno tardío
Authors: Guillermo Ailín A. , Fernández Fernando Julián
Published: September 2022

Se presenta el análisis zooarqueológico y tafonómico del sitio Álvarez 4, un alero emplazado en la cuenca media del río Limay en el noroeste de Patagonia, Río Negro, Argentina. Los restos faunísticos provienen del Período I (1100 ± 70 AP), del Período II (210 ± 90 AP), de la cuadrícula C3 (perturbada antrópicamente) y de la Capa Superficial (210 ± 90 AP). Se determinó una incidencia baja de procesos postdepositacionales. Se registró la acción de otros procesos tafonómicos como perturbación sedimentaria por causas antrópicas y posible migración de huesos. Una parte destacable de los restos ingresaron al sitio como descarte de alimentación humana y de la confección de instrumentos. Lama guanicoe fue el taxón más explotado en el sitio, aunque con algunas variaciones a lo largo de la secuencia. Se registró la explotación de Leopardus sp. en C3. En el Período I se utilizó Diplodon chilensis, Lama guanicoe, Conepatus chinga y Chaetophractus villosus. La incorporación de varios taxones (Rhea pennata, Lycalopex gymnocercus, Zaedyus pichiy, Lagidium viscacia y Caviinae indeterminado) en el Período II sugiere una ampliación de la dieta. Las especies exóticas halladas en la Capa Superficial, Ovis orientalis aries y Lepus europaeus, no formaron parte de la economía humana.