bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figures 1 - 8 from miRNA Biomarkers in Cyst Fluid Augment the Diagnosis and Management of Pancreatic Cysts
Authors: Matthaei Hanno , Wylie Dennis , Lloyd Maura B. , Dal Molin Marco , Kemppainen Jon , Mayo Skye C. , Wolfgang Christopher L. , Schulick Richard D. , Langfield Laura , Andruss Bernard F. , Adai Alex T. , Hruban Ralph H. , Szafranska-Schwarzbach Anna E. , Maitra Anirban
Published: April 2023

PDF file, 917K, Supplemental Figure 1: (A) Laser microdissection in an IPMN (hematoxylin and eosin; original magnification: 10x); (B) After precise marking and microdissection the neoplastic epithelium is catapulted into a sterile tube for subsequent RNA extraction. (C) The section after dissection. Supplemental Figure 2: Detailed diagram of the study design, describing experimental setup of FFPE (FTS) and cyst fluid (CFS) studies, including number of specimens used and number of miRNA candidates identified in the course of each study. Supplemental Figure 3: Mean Cts for all FTS and CFS specimens. (A) Megaplex RT-qPCR data for FTS. (B) and (C) Singleplex RT-qPCR data for FTS. (D) Megaplex RT-qPCR data for CFS. (E) and (F) Singleplex RT-qPCR data for CFS. Supplemental Figure 4: Boxplots showing raw Ct values for Megaplex (A) and singleplex (B) RT-qPCR expression analyses of FTS1 and FTS1 plus FTS2, respectively. The diagnosis associated with each sample is indicated by color, while the FTS1 and FTS2 specimens are depicted as separate panels in the singleplex boxplot (B). Supplemental Figure 5: Boxplots showing raw Ct values for Megaplex (A) and singleplex (B) RT-qPCR expression analyses of cyst fluid specimens from the CFS1 and CFS1 plus CFS2, respectively. Diagnosis is indicated by color, the CFS1 and CFS2 specimens by panel. Supplemental Figure 6: Boxplots of raw Ct values for singleplex RT-qPCR expression analysis of the CFS1 and CFS2 specimens with reassignment to test or training set indicated by separation of panels. Supplemental Figure 7: Raw Ct values of miRNAs involved in DiffPairs comprising the logistic regression model in the CFS1 and CFS2 specimens. Raw Ct for miR-21, which is not a part of the logistic regression model, are also shown. Supplemental Figure 8: PCA applied to raw Cts (A) and restricted mean-center normalized Cts. (B) CFS1 and CFS2 singleplex RT-qPCR data. Note that CFS1 and CFS2 specimens do not separate in either plot.
Supplementary Figure 1 from CpG Island Methylator Phenotype–Positive Tumors in the Absence of MLH1 Methylation Constitute a Distinct Subset of Duodenal Adenocarcinomas and Are Associated with Poor Prognosis
Authors: Fu Tao , Pappou Emmanouil P. , Guzzetta Angela A. , Jeschke Jana , Kwak Ruby , Dave Pujan , Hooker Craig M. , Morgan Richard , Baylin Stephen B. , Iacobuzio-Donahue Christine A. , Wolfgang Christopher L. , Ahuja Nita
Published: April 2023

PDF file, 382K, Summary of promoter hypermethylation frequency in CIMP− and CIMP+ duodenal adenocarcinomas as detected by methylation-specific PCR. Black and gray boxes indicate the presence or absence of hypermethylation, respectively.
Supplementary Table 2 from Functional Genetic Screens Identify Genes Essential for Tumor Cell Survival in Head and Neck and Lung Cancer
Authors: Martens-de Kemp Sanne R. , Nagel Remco , Stigter-van Walsum Marijke , van der Meulen Ida H. , van Beusechem Victor W. , Braakhuis Boudewijn J.M. , Brakenhoff Ruud H.
Published: April 2023

PDF file - 20K, The genome-wide siRNA screen in VU-SCC-120 revealed 140 siRNAs that caused a significant decrease in cell viability.
Supplementary Methods, Figure Legends, Table 1 from Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
Authors: Chodon Thinle , Comin-Anduix Begoña , Chmielowski Bartosz , Koya Richard C. , Wu Zhongqi , Auerbach Martin , Ng Charles , Avramis Earl , Seja Elizabeth , Villanueva Arturo , McCannel Tara A. , Ishiyama Akira , Czernin Johannes , Radu Caius G. , Wang Xiaoyan , Gjertson David W. , Cochran Alistair J. , Cornetta Kenneth , Wong Deborah J.L. , Kaplan-Lefko Paula , Hamid Omid , Samlowski Wolfram , Cohen Peter A. , Daniels Gregory A. , Mukherji Bijay , Yang Lili , Zack Jerome A. , Kohn Donald B. , Heath James R. , Glaspy John A. , Witte Owen N. , Baltimore David , Economou James S. , Ribas Antoni
Published: April 2023

PDF file - 148KB, Supplementary Table 1. Toxicities and response to therapy with the subsequent protocol amendments.
Supplementary Figure 5 from Sustained Inhibition of Receptor Tyrosine Kinases and Macrophage Depletion by PLX3397 and Rapamycin as a Potential New Approach for the Treatment of MPNSTs
Authors: Patwardhan Parag P. , Surriga Oliver , Beckman Michael J. , de Stanchina Elisa , Dematteo Ronald P. , Tap William D. , Schwartz Gary K.
Published: April 2023

PDF file - 168KB, Effect of PLX3397 on Ki67, a cellular proliferation marker and CD31, an endothelial cell marker in MPNST xenografts.
Supplementary Figure 4 from Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
Authors: Chodon Thinle , Comin-Anduix Begoña , Chmielowski Bartosz , Koya Richard C. , Wu Zhongqi , Auerbach Martin , Ng Charles , Avramis Earl , Seja Elizabeth , Villanueva Arturo , McCannel Tara A. , Ishiyama Akira , Czernin Johannes , Radu Caius G. , Wang Xiaoyan , Gjertson David W. , Cochran Alistair J. , Cornetta Kenneth , Wong Deborah J.L. , Kaplan-Lefko Paula , Hamid Omid , Samlowski Wolfram , Cohen Peter A. , Daniels Gregory A. , Mukherji Bijay , Yang Lili , Zack Jerome A. , Kohn Donald B. , Heath James R. , Glaspy John A. , Witte Owen N. , Baltimore David , Economou James S. , Ribas Antoni
Published: April 2023

PDF file - 278KB, Pre- and post-treatment PET scans showing evidence of major tumor response and MART-1-specific TCR transgenic cell levels in patient F5-10.
Supplementary Figure 3 from Adoptive Transfer of MART-1 T-Cell Receptor Transgenic Lymphocytes and Dendritic Cell Vaccination in Patients with Metastatic Melanoma
Authors: Chodon Thinle , Comin-Anduix Begoña , Chmielowski Bartosz , Koya Richard C. , Wu Zhongqi , Auerbach Martin , Ng Charles , Avramis Earl , Seja Elizabeth , Villanueva Arturo , McCannel Tara A. , Ishiyama Akira , Czernin Johannes , Radu Caius G. , Wang Xiaoyan , Gjertson David W. , Cochran Alistair J. , Cornetta Kenneth , Wong Deborah J.L. , Kaplan-Lefko Paula , Hamid Omid , Samlowski Wolfram , Cohen Peter A. , Daniels Gregory A. , Mukherji Bijay , Yang Lili , Zack Jerome A. , Kohn Donald B. , Heath James R. , Glaspy John A. , Witte Owen N. , Baltimore David , Economou James S. , Ribas Antoni
Published: April 2023

PDF file - 127KB, Number and function of TCR transgenic cells infused.
Supplementary Table 1 from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Authors: Zhang Ying , Farenholtz Kaitlyn E. , Yang Yanzhi , Guessous Fadila , diPierro Charles G. , Calvert Valerie S. , Deng Jianghong , Schiff David , Xin Wenjun , Lee Jae K. , Purow Benjamin , Christensen James , Petricoin Emanuel , Abounader Roger
Published: April 2023

PDF file - 54K, Regression and Spearman (rank-based) correlation analyses between the molecular parameters and cell responsiveness to METi
Supplementary Methods from Hepatocyte Growth Factor Sensitizes Brain Tumors to c-MET Kinase Inhibition
Authors: Zhang Ying , Farenholtz Kaitlyn E. , Yang Yanzhi , Guessous Fadila , diPierro Charles G. , Calvert Valerie S. , Deng Jianghong , Schiff David , Xin Wenjun , Lee Jae K. , Purow Benjamin , Christensen James , Petricoin Emanuel , Abounader Roger
Published: April 2023

PDF file - 60K, Methods for cell and tissue culture and Reverse Phase Protein Microarray Construction and Analysis
Supplementary Figure 7 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Authors: Stefanska Barbara , Cheishvili David , Suderman Matthew , Arakelian Ani , Huang Jian , Hallett Michael , Han Ze-Guang , Al-Mahtab Mamun , Akbar Sheikh Mohammad Fazle , Khan Wasif Ali , Raqib Rubhana , Tanvir Imrana , Khan Haseeb Ahmed , Rabbani Shafaat A. , Szyf Moshe
Published: April 2023

PDF file - 690KB, Supplementary Figure S7. Impact of RASAL2 and NENF depletion on on expression of genes of DNA methylation machinery, DNMT1, MBD2, DNMT3A, and DNMT3B. DNMT1 (A), MBD2 (B), DNMT3A (C), and DNMT3B (D) expression levels quantified by QPCR in HepG2 and SkHep1 liver cancer cells transfected with siRASAL2 or siNENF as compared to siCtrl. All results represent mean � S.D. of three determinations in either two or three independent experiments - ***P < 0.001, **P < 0.01, *P < 0.05.
Supplementary Methods-S1-15 and Tables-S1-4 from ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
Authors: Huang Hsuan-Ying , Wu Wen-Ren , Wang Yu-Hui , Wang Jun-Wen , Fang Fu-Min , Tsai Jen-Wei , Li Shau-Hsuan , Hung Hsiao-Chin , Yu Shih-Chen , Lan Jui , Shiue Yow-Ling , Hsing Chung-His , Chen Li-Tzong , Li Chien-Feng
Published: April 2023

Supplementary Methods-S1-15 and Tables-S1-4 PDF file 243K, The file contains Supplementary Methods S1-15 and legends for Supplementary Tables S1-4
Figure-S6 from ASS1 as a Novel Tumor Suppressor Gene in Myxofibrosarcomas: Aberrant Loss via Epigenetic DNA Methylation Confers Aggressive Phenotypes, Negative Prognostic Impact, and Therapeutic Relevance
Authors: Huang Hsuan-Ying , Wu Wen-Ren , Wang Yu-Hui , Wang Jun-Wen , Fang Fu-Min , Tsai Jen-Wei , Li Shau-Hsuan , Hung Hsiao-Chin , Yu Shih-Chen , Lan Jui , Shiue Yow-Ling , Hsing Chung-His , Chen Li-Tzong , Li Chien-Feng
Published: April 2023

Figure-S6 PDF file 78K, Figure-S6 ASS1 knockdown promotes cell proliferation, viability, migration, and invasion in LPS510 cells that endogenously express ASS1. (A) Among the 4 liposarcoma cell lines tested, endogenous ASS1 mRNA and protein are only readily detected in LPS510 cells by quantitative RT-PCR (upper) and Western blotting assays (lower), respectively. CCD966SK fibroblasts are run in parallel as a positive control. (B) Stable silencing of ASS1 gene with shASS1 in LPS510 cells show significantly downregulated expression at the mRNA and protein levels as detected by real-time RT-PCR (upper) and Western blotting (lower) assays, respectively. The shLacZ plasmid, POLR2A transcript, and GADPH protein are utilized as controls in RNA interference, quantitative RT-PCR, and Western blotting assays, respectively. (C) Results of Brdu (left upper), XTT (right upper), transwell migration (left lower), and matrigel invasion (right lower) assays reveal that the functions of cell proliferation, cell viability, cell motility, and cell invasiveness are significantly impaired in shLacZ control (all p��0.05) as compared to the LPS510 cells stably silenced against ASS1 expression. All functional experiments are performed in triplicate and results expressed as mean �} SD
Supplementary Figure 1 from Genome-Wide Study of Hypomethylated and Induced Genes in Patients with Liver Cancer Unravels Novel Anticancer Targets
Authors: Stefanska Barbara , Cheishvili David , Suderman Matthew , Arakelian Ani , Huang Jian , Hallett Michael , Han Ze-Guang , Al-Mahtab Mamun , Akbar Sheikh Mohammad Fazle , Khan Wasif Ali , Raqib Rubhana , Tanvir Imrana , Khan Haseeb Ahmed , Rabbani Shafaat A. , Szyf Moshe
Published: April 2023

PDF file - 961KB, Supplementary Figure S1. (A,B) Extensive methylation analysis of RASAL2 (A) and NENF (B) promoters in cells treated with 5-azaCdR, different cell lines and patients. Average methylation state of CpG sites was determined by pyrosequencing in NorHep and HepG2 cells treated with 1.0 microM 5-azaCdR for 3 days, in control HepG2, SkHep1 and NorHep cells, as well as in HCC patients. All results represent mean � S.D. of two or three independent experiments - ***P < 0.001, **P < 0.01, *P < 0.05. Methylation level of 58 CpG sites was determined within RASAL2 in NorHep treated with 5-azaCdR (note that for convenience CpGs were numbered relative to CpGs shown in Figure 1). Five sets of primers encompassing 1446 bp fragment were used (Supplementary Table S1C). Since no relevant changes at CpGs upstream to CpGs 1-3 were observed, the number of tested regions was limited to 13 CpGs in patients and 14 CpGs in HepG2 cells treated with 5-azaCdR and in the comparison of methylation state in different cell lines. The most relevant changes were observed at CpGs 1-3 as shown in Figure 1. Only methylation at these sites distinguished normal hepatocytes from cancer cells. Within NENF promoter, methylation level of 27 CpGs was tested in NorHep treated with 5-azaCdR. Three sets of primers encompassing 846 bp fragment were used (Supplementary Table S1C). Since no relevant changes at CpGs upstream to CpG (-)2 were observed, the number of tested regions was limited to 13 CpGs in patients and 17 CpGs in HepG2 cells treated with 5-azaCdR and in the comparison of methylation state in different cell lines. The most relevant changes were observed at CpGs 1-5 as shown in Figure 1.
Supplementary Tables 1 - 2 from Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-l-glutamate for Imaging xC− Transporter Using Positron Emission Tomography in Patients with Non–Small Cell Lung or Breast Cancer
Authors: Baek Sora , Choi Chang-Min , Ahn Sei Hyun , Lee Jong Won , Gong Gyungyub , Ryu Jin-Sook , Oh Seung Jun , Bacher-Stier Claudia , Fels Lüder , Koglin Norman , Hultsch Christina , Schatz Christoph A. , Dinkelborg Ludger M. , Mittra Erik S. , Gambhir Sanjiv S. , Moon Dae Hyuk
Published: April 2023

PDF file, 72K, S1: Clinical safety laboratory parameters; S2: Tissue distribution of 18FFSPG.
Supplementary Movie 1B from Exploratory Clinical Trial of (4S)-4-(3-[18F]fluoropropyl)-l-glutamate for Imaging xC− Transporter Using Positron Emission Tomography in Patients with Non–Small Cell Lung or Breast Cancer
Authors: Baek Sora , Choi Chang-Min , Ahn Sei Hyun , Lee Jong Won , Gong Gyungyub , Ryu Jin-Sook , Oh Seung Jun , Bacher-Stier Claudia , Fels Lüder , Koglin Norman , Hultsch Christina , Schatz Christoph A. , Dinkelborg Ludger M. , Mittra Erik S. , Gambhir Sanjiv S. , Moon Dae Hyuk
Published: April 2023

AVI, 180K, Maximum intensity projection of 18FFSPG in a lung cancer patient (Patient 2).
Supplementary Figure 2 from Aberrant Expression of Mucin Core Proteins and O-Linked Glycans Associated with Progression of Pancreatic Cancer
Authors: Remmers Neeley , Anderson Judy M. , Linde Erin M. , DiMaio Dominick J. , Lazenby Audrey J. , Wandall Hans H. , Mandel Ulla , Clausen Henrik , Yu Fang , Hollingsworth Michael A.
Published: April 2023

PDF file - 320K, Supplementary Figure 2. Representative immunohistochemical results for comparison of cancer fieldeffects in autopsy and resection tissue samples from the same patients. Two different autopsy patients who underwent surgical resection are presented. Serial sections stained for the antigens indicated are shown in the resection tissue samples alongside the autopsy samples of their primary tumors. 200x magnification.
Supplementary Figure 3 from Prediction of Survival in Resected Non–Small Cell Lung Cancer Using a Protein Expression–Based Risk Model: Implications for Personalized Chemoprevention and Therapy
Authors: Gold Kathryn A. , Kim Edward S. , Liu Diane D. , Yuan Ping , Behrens Carmen , Solis Luisa M. , Kadara Humam , Rice David C. , Wistuba Ignacio I. , Swisher Stephen G. , Hofstetter Wayne L. , Lee J. Jack , Hong Waun K.
Published: April 2023

PDF file - 84K, Kaplan Meier curves for RFS and OS by marker group for patients with stage I NSCLC.
Supplementary Figure 1 from Number of Target Lesions for EASL and Modified RECIST to Predict Survivals in Hepatocellular Carcinoma Treated with Chemoembolization
Authors: Kim Beom Kyung , Kim Seung Up , Kim Myeong-Jin , Kim Kyung Ah , Kim Do Young , Park Jun Yong , Ahn Sang Hoon , Han Kwang-Hyub , Chon Chae Yoon
Published: April 2023

PDF file - 30K, Flowchart describing the selection of the study population
Supplementary Figures 15 - 17, Table 8 from Integrative Analysis of 1q23.3 Copy-Number Gain in Metastatic Urothelial Carcinoma
Authors: Riester Markus , Werner Lillian , Bellmunt Joaquim , Selvarajah Shamini , Guancial Elizabeth A. , Weir Barbara A. , Stack Edward C. , Park Rachel S. , O'Brien Robert , Schutz Fabio A.B. , Choueiri Toni K. , Signoretti Sabina , Lloreta Josep , Marchionni Luigi , Gallardo Enrique , Rojo Federico , Garcia Denise I. , Chekaluk Yvonne , Kwiatkowski David J. , Bochner Bernard H. , Hahn William C. , Ligon Azra H. , Barletta Justine A. , Loda Massimo , Berman David M. , Kantoff Philip W. , Michor Franziska , Rosenberg Jonathan E.
Published: April 2023

PDF file - 452KB, Independent validation; Validation of 1q23.3 survival association in independent cohorts; Figure S15: Expression of genes on 1q23.3 in an independent cohort 3; S16: Expression of genes on 1q23.3 as in Supplemental Figure S15, but in the Spanish (a-b) and DFCI (c-d) cohorts. Panels (a) and (c) are for samples with 1q23.3 gain or amplification (log2 copy number ratio > 0.15), (b) and (d) for patients without amplification; S17: Panel (a): No association of overall survival after surgery and 1q23.3 amplification in an inde- pendent cohort from DFCI. (b) No significant association of 1q23.3 amplification and OS after recurrence, possibly due to small patient numbers; Table S8: Overall survival (OS) Hazard Ratios (HRs) of genes in the three peaks, available on the Affymetrix HGU133 Plus 2.0 genechip and displaying patterns of gene expression different from background noise as identified by the Sleipnir library 1. The LMX1A gene was flat, i.e., showed minimum expression intensity in all patients. Table S9: Overall survival (OS) Hazard Ratios (HRs) of genes in 1q21.2 as in Supplementary Table S8.
Supplementary Table 7 from Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer
Authors: Sun Xuezheng , Gierach Gretchen L. , Sandhu Rupninder , Williams Tyisha , Midkiff Bentley R. , Lissowska Jolanta , Wesolowska Ewa , Boyd Norman F. , Johnson Nicole B. , Figueroa Jonine D. , Sherman Mark E. , Troester Melissa A.
Published: April 2023

Supplementary Table 7 - PDF file 49K, Adjusted relationship of biologically relevant signatures with the Active/Inactive extratumoral microenvironment subtype, mammographic density, and breast composition
Supplementary Figure Legends from Integrative Analysis of 1q23.3 Copy-Number Gain in Metastatic Urothelial Carcinoma
Authors: Riester Markus , Werner Lillian , Bellmunt Joaquim , Selvarajah Shamini , Guancial Elizabeth A. , Weir Barbara A. , Stack Edward C. , Park Rachel S. , O'Brien Robert , Schutz Fabio A.B. , Choueiri Toni K. , Signoretti Sabina , Lloreta Josep , Marchionni Luigi , Gallardo Enrique , Rojo Federico , Garcia Denise I. , Chekaluk Yvonne , Kwiatkowski David J. , Bochner Bernard H. , Hahn William C. , Ligon Azra H. , Barletta Justine A. , Loda Massimo , Berman David M. , Kantoff Philip W. , Michor Franziska , Rosenberg Jonathan E.
Published: April 2023

PDF file - 81KB
Supplementary Table 3 from Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer
Authors: Sun Xuezheng , Gierach Gretchen L. , Sandhu Rupninder , Williams Tyisha , Midkiff Bentley R. , Lissowska Jolanta , Wesolowska Ewa , Boyd Norman F. , Johnson Nicole B. , Figueroa Jonine D. , Sherman Mark E. , Troester Melissa A.
Published: April 2023

Supplementary Table 3 - PDF file 23K, Overlaps in genes among biologically relevant signatures
Supplementary Tables 1-5 from Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma
Authors: Liang Beibei , Chen Rui , Wang Tao , Cao Lei , Liu Yingying , Yin Fan , Zhu Minhui , Fan Xiaoyu , Liang Yingchao , Zhang Lu , Guo Yajun , Zhao Jian
Published: April 2023

The clinicopathologic characteristics of 110 cases of HCC, relationship between MyD88 expression and survival rate, Lenti-Virus shMyD88 inhibit tumorigenesis and metastasis of MHCC-PDF File - 194K, LM3 cells in nude mice, primers used in this study and antibodies used in this study.
Supplementary Figure 3 from Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer
Authors: Sun Xuezheng , Gierach Gretchen L. , Sandhu Rupninder , Williams Tyisha , Midkiff Bentley R. , Lissowska Jolanta , Wesolowska Ewa , Boyd Norman F. , Johnson Nicole B. , Figueroa Jonine D. , Sherman Mark E. , Troester Melissa A.
Published: April 2023

Supplementary Figure 3 - PDF file 55K, Cluster discovery consensus matrix and dendrogram of gene expression level of the 3194 genes of the published Active/Inactive signature
Supplementary Figure 1 from Relationship of Mammographic Density and Gene Expression: Analysis of Normal Breast Tissue Surrounding Breast Cancer
Authors: Sun Xuezheng , Gierach Gretchen L. , Sandhu Rupninder , Williams Tyisha , Midkiff Bentley R. , Lissowska Jolanta , Wesolowska Ewa , Boyd Norman F. , Johnson Nicole B. , Figueroa Jonine D. , Sherman Mark E. , Troester Melissa A.
Published: April 2023

Supplementary Figure 1 - PDF file 385K, Representative pictures of breast composition by digital pathological image analysis
Supplementary Figure 1 from Myeloid Differentiation Factor 88 Promotes Growth and Metastasis of Human Hepatocellular Carcinoma
Authors: Liang Beibei , Chen Rui , Wang Tao , Cao Lei , Liu Yingying , Yin Fan , Zhu Minhui , Fan Xiaoyu , Liang Yingchao , Zhang Lu , Guo Yajun , Zhao Jian
Published: April 2023

PDF File - 4550K, Photographs of immunostaining of MyD88 and CD68 in serial sections from HCC tissue samples were taken for further analyses.
Supplementary Table 4 from Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer
Authors: Davis Sally J. , Sheppard Karen E. , Pearson Richard B. , Campbell Ian G. , Gorringe Kylie L. , Simpson Kaylene J.
Published: April 2023

PDF file - 68K, Z = -1.5 and corresponding loss of viability for all cell lines
Supplementary Table 1 from Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer
Authors: Davis Sally J. , Sheppard Karen E. , Pearson Richard B. , Campbell Ian G. , Gorringe Kylie L. , Simpson Kaylene J.
Published: April 2023

PDF file - 68K, Cell line culture and transfection conditions
Supplementary Table 1 from Gene Expression Profiling using Nanostring Digital RNA Counting to Identify Potential Target Antigens for Melanoma Immunotherapy
Authors: Beard Rachel E. , Abate-Daga Daniel , Rosati Shannon F. , Zheng Zhili , Wunderlich John R. , Rosenberg Steven A. , Morgan Richard A.
Published: April 2023

PDF file - 79K, Supplemental Table S1. Reactivity of target melanoma lines based on previous published data.
Supplementary Figure 1 from Functional Analysis of Genes in Regions Commonly Amplified in High-Grade Serous and Endometrioid Ovarian Cancer
Authors: Davis Sally J. , Sheppard Karen E. , Pearson Richard B. , Campbell Ian G. , Gorringe Kylie L. , Simpson Kaylene J.
Published: April 2023

PDF file - 155K, Screen control metrics
Supplementary Figure 1 from Gene Expression Profiling using Nanostring Digital RNA Counting to Identify Potential Target Antigens for Melanoma Immunotherapy
Authors: Beard Rachel E. , Abate-Daga Daniel , Rosati Shannon F. , Zheng Zhili , Wunderlich John R. , Rosenberg Steven A. , Morgan Richard A.
Published: April 2023

PDF file - 198K, Supplemental Figure S1. PCA for tumor samples (n=59) based on site metastatic deposit of resected tumor.
Supplementary Tables 1 - 4 from Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non–Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models
Authors: Zhang Jingchuan , Zhang Lin , Su Xinying , Li Ming , Xie Liang , Malchers Florian , Fan ShuQiong , Yin XiaoLu , Xu YanPing , Liu Kunji , Dong Zhengwei , Zhu Guanshan , Qian Ziliang , Tang Lili , Zhan Ping , Ji Qunsheng , Kilgour Elaine , Smith Paul D. , Brooks A. Nigel , Thomas Roman K. , Gavine Paul R.
Published: April 2023

PDF file - 94K, Supplementary Table 1. AZD4547 GI50 comparisons between FGFR1-amplified DMS114 and EGFR-mutant NCI-H1975 cell lines. Supplementary Table 2. Dynamic modulation of pERK, pS6, Ki67 and CC3 markers in model L121 tumor sections treated with a single dose of 12.5mg/kg AZD4547. Supplementary Table 3. Statistical association analysis of tumor histology and patient smoking status. Supplementary Table 4. FGFR1 amplification shows high mutual exclusivity with EGFR, Kras and EML4-ALK status in Chinese NSCLC.
Supplementary Figure Legend from Translating the Therapeutic Potential of AZD4547 in FGFR1-Amplified Non–Small Cell Lung Cancer through the Use of Patient-Derived Tumor Xenograft Models
Authors: Zhang Jingchuan , Zhang Lin , Su Xinying , Li Ming , Xie Liang , Malchers Florian , Fan ShuQiong , Yin XiaoLu , Xu YanPing , Liu Kunji , Dong Zhengwei , Zhu Guanshan , Qian Ziliang , Tang Lili , Zhan Ping , Ji Qunsheng , Kilgour Elaine , Smith Paul D. , Brooks A. Nigel , Thomas Roman K. , Gavine Paul R.
Published: April 2023

PDF file - 64K
Supplementary Information from Downregulation of miR-452 Promotes Stem-Like Traits and Tumorigenicity of Gliomas
Authors: Liu Liping , Chen Kun , Wu Jueheng , Shi Ling , Hu Bo , Cheng Shiyuan , Li Mengfeng , Song Libing
Published: April 2023

Supplementary Information
Supplementary Figure 4 from Downregulation of miR-452 Promotes Stem-Like Traits and Tumorigenicity of Gliomas
Authors: Liu Liping , Chen Kun , Wu Jueheng , Shi Ling , Hu Bo , Cheng Shiyuan , Li Mengfeng , Song Libing
Published: April 2023

miR-452 overexpression represses Wnt/β-catenin signaling.
Supplementary Tables 1 and 2 from Genetic Variations Associated with Postoperative Recurrence in Stage I Non–Small Cell Lung Cancer
Authors: Yoon Kyong-Ah , Jung Mee Kyung , Lee Donghoon , Bae Kieun , Joo Jung Nam , Lee Geon Kook , Lee Hyun-Sung , Lee Jin Soo
Published: April 2023

PDF - 150K, Supplementary Table S1. Association analysis of 94 SNPs with RFS Supplementary Table S2. Association analysis of SNPs in Chr4q34 with RFS.
Supplementary Figure 2 from Anti-HDGF Targets Cancer and Cancer Stromal Stem Cells Resistant to Chemotherapy
Authors: Zhao Jun , Ma Mark Z. , Ren Hening , Liu Zhenqiu , Edelman Martin J. , Pan Hong , Mao Li
Published: April 2023

Supplementary Figure 2 - PDF file 693K, Notch intracellular domain IHC
Supplementary Table 3c from AIB1:ERα Transcriptional Activity Is Selectively Enhanced in Aromatase Inhibitor–Resistant Breast Cancer Cells
Authors: O'Hara Jane , Vareslija Damir , McBryan Jean , Bane Fiona , Tibbitts Paul , Byrne Christopher , Conroy Ronán M. , Hao Yuan , Gaora Peadar Ó , Hill Arnold D.K. , McIlroy Marie , Young Leonie S.
Published: April 2023

PDF file, 113KB, Supplementary Table 3c ER/AIB1 overlap genelist - no ERE.
Supplementary Tables from Protein Kinase C-δ–Mediated Recycling of Active KIT in Colon Cancer
Authors: Park Misun , Kim Won Kyu , Song Meiying , Park Minhee , Kim Hyunki , Nam Hye Jin , Baek Sung Hee , Kim Hoguen
Published: April 2023

PDF file, 160K, Supplementary Table 1. Primer and siRNA sequences Supplementary Table 2. Clinicopathological characteristics of 250 colorectal cancers according to KIT expression.
Supplementary Table 1 from Potentially Prognostic miRNAs in HPV-Associated Oropharyngeal Carcinoma
Authors: Hui Angela B.Y. , Lin Alice , Xu Wei , Waldron Levi , Perez-Ordonez Bayardo , Weinreb Ilan , Shi Wei , Bruce Jeff , Huang Shao Hui , O'Sullivan Brian , Waldron John , Gullane Patrick , Irish Jonathan C. , Chan Kelvin , Liu Fei-Fei
Published: April 2023

PDF file - 31K, The list of the aberrantly-expressed miRNAs between OPC and normals
Supplemental Figure 5 from Dual Targeting of the Type 1 Insulin-like Growth Factor Receptor and Its Ligands as an Effective Antiangiogenic Strategy
Authors: Bid Hemant K. , London Cheryl A. , Gao Jin , Zhong Haihong , Hollingsworth Robert E. , Fernandez Soledad , Mo Xiaokui , Houghton Peter J.
Published: April 2023

Supplemental Figure 5 PDF file 132K, Photomicrograph
Supplementary Figure 2 from Potentially Prognostic miRNAs in HPV-Associated Oropharyngeal Carcinoma
Authors: Hui Angela B.Y. , Lin Alice , Xu Wei , Waldron Levi , Perez-Ordonez Bayardo , Weinreb Ilan , Shi Wei , Bruce Jeff , Huang Shao Hui , O'Sullivan Brian , Waldron John , Gullane Patrick , Irish Jonathan C. , Chan Kelvin , Liu Fei-Fei
Published: April 2023

PDF file - 31K, Comparison of miRNA expression between tumor and normal samples
Supplemental Figure 2 from Dual Targeting of the Type 1 Insulin-like Growth Factor Receptor and Its Ligands as an Effective Antiangiogenic Strategy
Authors: Bid Hemant K. , London Cheryl A. , Gao Jin , Zhong Haihong , Hollingsworth Robert E. , Fernandez Soledad , Mo Xiaokui , Houghton Peter J.
Published: April 2023

Supplemental Figure 2 PDF file 143K, Western Blot
Supplementary Figure 4 from Primate-Specific miR-663 Functions as a Tumor Suppressor by Targeting PIK3CD and Predicts the Prognosis of Human Glioblastoma
Authors: Shi Yu , Chen Cong , Zhang Xia , Liu Qing , Xu Jin-Ling , Zhang Hua-Rong , Yao Xiao-Hong , Jiang Tao , He Zhi-Cheng , Ren Yong , Cui Wei , Xu Chuan , Liu Ling , Cui You-Hong , Yu Shi-Zhu , Ping Yi-Fang , Bian Xiu-Wu
Published: April 2023

PDF file - 1654K, Supplementary Fig. S4. The suppressive effects of miR-663 on PIK3CD and its downstream proliferation and invasion-related targets.
Supplementary Table 1 from Alternative Cleavage and Polyadenylation during Colorectal Cancer Development
Authors: Morris Adam R. , Bos Arnold , Diosdado Begoña , Rooijers Koos , Elkon Ran , Bolijn Anne S. , Carvalho Beatriz , Meijer Gerrit A. , Agami Reuven
Published: April 2023

PDF file - 3.2MB, PAS_J values and p-values describing APA during colon cancer progression
Supplementary Figure 3 from Alternative Cleavage and Polyadenylation during Colorectal Cancer Development
Authors: Morris Adam R. , Bos Arnold , Diosdado Begoña , Rooijers Koos , Elkon Ran , Bolijn Anne S. , Carvalho Beatriz , Meijer Gerrit A. , Agami Reuven
Published: April 2023

PDF file - 97K, Correlation between APA and mRNA abundance. Negative PAS_J values indicate 3'UTR shortening, and vice versa
Supplementary Figure Legend from Phase II Study of Lutetium-177–Labeled Anti-Prostate-Specific Membrane Antigen Monoclonal Antibody J591 for Metastatic Castration-Resistant Prostate Cancer
Authors: Tagawa Scott T. , Milowsky Matthew I. , Morris Michael , Vallabhajosula Shankar , Christos Paul , Akhtar Naveed H. , Osborne Joseph , Goldsmith Stanley J. , Larson Steve , Taskar Neeta Pandit , Scher Howard I. , Bander Neil H. , Nanus David M.
Published: April 2023

PDF file - 47K
Supplementary Figure Legends from Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
Authors: Sanford Dominic E. , Belt Brian A. , Panni Roheena Z. , Mayer Allese , Deshpande Anjali D. , Carpenter Danielle , Mitchem Jonathan B. , Plambeck-Suess Stacey M. , Worley Lori A. , Goetz Brian D. , Wang-Gillam Andrea , Eberlein Timothy J. , Denardo David G. , Goedegebuure Simon Peter , Linehan David C.
Published: April 2023

PDF - 85K.
Supplementary Figure 3 from Inflammatory Monocyte Mobilization Decreases Patient Survival in Pancreatic Cancer: A Role for Targeting the CCL2/CCR2 Axis
Authors: Sanford Dominic E. , Belt Brian A. , Panni Roheena Z. , Mayer Allese , Deshpande Anjali D. , Carpenter Danielle , Mitchem Jonathan B. , Plambeck-Suess Stacey M. , Worley Lori A. , Goetz Brian D. , Wang-Gillam Andrea , Eberlein Timothy J. , Denardo David G. , Goedegebuure Simon Peter , Linehan David C.
Published: April 2023

PDF - 432K, CCL2 expression in increased in murine pancreatic cancer.
Supplementary Table 3 from Identification and Validation of a Blood-Based 18-Gene Expression Signature in Colorectal Cancer
Authors: Xu Ye , Xu Qinghua , Yang Li , Ye Xun , Liu Fang , Wu Fei , Ni Shujuan , Tan Cong , Cai Guoxiang , Meng Xia , Cai Sanjun , Du Xiang
Published: April 2023

PDF file - 65K, Association between samples' characteristics and signature prediction outcomes.
Supplementary Figure 1 from Identification and Validation of a Blood-Based 18-Gene Expression Signature in Colorectal Cancer
Authors: Xu Ye , Xu Qinghua , Yang Li , Ye Xun , Liu Fang , Wu Fei , Ni Shujuan , Tan Cong , Cai Guoxiang , Meng Xia , Cai Sanjun , Du Xiang
Published: April 2023

PDF file - 151K, On the heat map, red colors indicate genes upregulated and green colors indicate genes downregulated. Among the 263 genes, 179 were up-regulated and 84 were down-regulated in the cancer patients, respectively. On the hierarchical clustering diagram, green bars represent controls and red bars represent CRC patients. Two hundred samples appeared to be distributed into two major separate clusters with few overlaps, revealing distinct gene expression patterns between the CRC group and the Control group.
Supplementary Table 2 from HDAC Inhibitors Enhance T-Cell Chemokine Expression and Augment Response to PD-1 Immunotherapy in Lung Adenocarcinoma
Authors: Zheng Hong , Zhao Weipeng , Yan Cihui , Watson Crystina C. , Massengill Michael , Xie Mengyu , Massengill Chris , Noyes David R. , Martinez Gary V. , Afzal Roha , Chen Zhihua , Ren Xiubao , Antonia Scott J. , Haura Eric B. , Ruffell Brian , Beg Amer A.
Published: April 2023

Supplementary Table 2. Probe sets showing 2-fold difference in expression in 2 independent experiments with romidepsin treatment of LKR. Probe sets with very low expression (cutoff of <100 under all tested conditions) were removed. Probe set ID, direction of change after romidepsin treatment, accession number and gene symbol when available are indicated.
Supplementary Figure Legend from Thalidomide in Total Therapy 2 Overcomes Inferior Prognosis of Myeloma with Low Expression of the Glucocorticoid Receptor Gene NR3C1
Authors: Heuck Christoph J. , Szymonifka Jackie , Hansen Emily , Shaughnessy John D. , Usmani Saad Z. , van Rhee Frits , Anaissie Elias , Nair Bijay , Waheed Sarah , Alsayed Yazan , Petty Nathan , Bailey Clyde , Epstein Joshua , Hoering Antje , Crowley John , Barlogie Bart
Published: April 2023

PDF file, 88K.
Supplementary Figure 5 from Thalidomide in Total Therapy 2 Overcomes Inferior Prognosis of Myeloma with Low Expression of the Glucocorticoid Receptor Gene NR3C1
Authors: Heuck Christoph J. , Szymonifka Jackie , Hansen Emily , Shaughnessy John D. , Usmani Saad Z. , van Rhee Frits , Anaissie Elias , Nair Bijay , Waheed Sarah , Alsayed Yazan , Petty Nathan , Bailey Clyde , Epstein Joshua , Hoering Antje , Crowley John , Barlogie Bart
Published: April 2023

PDF file, 94K, Post-relapse survival according to NR3C1 levels at baseline and at relapse.
Supplementary Figure 4 from Thalidomide in Total Therapy 2 Overcomes Inferior Prognosis of Myeloma with Low Expression of the Glucocorticoid Receptor Gene NR3C1
Authors: Heuck Christoph J. , Szymonifka Jackie , Hansen Emily , Shaughnessy John D. , Usmani Saad Z. , van Rhee Frits , Anaissie Elias , Nair Bijay , Waheed Sarah , Alsayed Yazan , Petty Nathan , Bailey Clyde , Epstein Joshua , Hoering Antje , Crowley John , Barlogie Bart
Published: April 2023

PDF file, 136K, Kaplan-Meier plots for overall survival from start of first salvage therapy.
Supplementary table S2 from Interobserver Agreement in Describing the Ultrasound Appearance of Adnexal Masses and in Calculating the Risk of Malignancy Using Logistic Regression Models
Authors: Sladkevicius Povilas , Valentin Lil
Published: April 2023

Supplementary table S2. It describes which variables describing the adnexal masses differed between two observes when estimated risk was >25 percentage units using logistic regression model 1 (LR1)
Supplementary Figure 1 from Thalidomide in Total Therapy 2 Overcomes Inferior Prognosis of Myeloma with Low Expression of the Glucocorticoid Receptor Gene NR3C1
Authors: Heuck Christoph J. , Szymonifka Jackie , Hansen Emily , Shaughnessy John D. , Usmani Saad Z. , van Rhee Frits , Anaissie Elias , Nair Bijay , Waheed Sarah , Alsayed Yazan , Petty Nathan , Bailey Clyde , Epstein Joshua , Hoering Antje , Crowley John , Barlogie Bart
Published: April 2023

PDF file, 256K, Thalidomide effect on overall and progression-free survival according to glucocorticoid receptor (NR3C1) expression level.
Figure S3 from Interobserver Agreement in Describing the Ultrasound Appearance of Adnexal Masses and in Calculating the Risk of Malignancy Using Logistic Regression Models
Authors: Sladkevicius Povilas , Valentin Lil
Published: April 2023

Figure S3. Relationship between number of days between the two examinations and inter-observer difference in maximal diameter of the largest solid component in benign and malignant tumors is shown on this scatterplot
Data Supplement from Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer
Authors: Li Xuqi , Wang Zheng , Ma Qingyong , Xu Qinhong , Liu Han , Duan Wanxing , Lei Jianjun , Ma Jiguang , Wang Xiu , Lv Shifang , Han Liang , Li Wei , Guo Jian , Guo Kun , Zhang Dong , Wu Erxi , Xie Keping
Published: April 2023

Supplementary Table 1:PCR Primer Sequence; Supplementary Table 2:Clinicopathological information of patients; Supplementary Table 3:Univariate and multivariate analysis of different prognostic parameters;Supplementary Table 4:Correction between expression of SHH and clinicopathological features; Supplementary Figure 1-6 Legends.
Data Supplement from Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer
Authors: Li Xuqi , Wang Zheng , Ma Qingyong , Xu Qinhong , Liu Han , Duan Wanxing , Lei Jianjun , Ma Jiguang , Wang Xiu , Lv Shifang , Han Liang , Li Wei , Guo Jian , Guo Kun , Zhang Dong , Wu Erxi , Xie Keping
Published: April 2023

Supplementary Figure 1.Co-culture model of PCa tumor cells - DRGs in Supplementary Figure 1.Co-culture model of PCa tumor cells - DRGs in vitrovitro.
Data Supplement from Sonic Hedgehog Paracrine Signaling Activates Stromal Cells to Promote Perineural Invasion in Pancreatic Cancer
Authors: Li Xuqi , Wang Zheng , Ma Qingyong , Xu Qinhong , Liu Han , Duan Wanxing , Lei Jianjun , Ma Jiguang , Wang Xiu , Lv Shifang , Han Liang , Li Wei , Guo Jian , Guo Kun , Zhang Dong , Wu Erxi , Xie Keping
Published: April 2023

Supplementary Figure 5.Autocrine SHH did not influence cell activity or the Hh pathway.
Supplemental Table 3 from A let-7 microRNA-Binding Site Polymorphism in KRAS Predicts Improved Outcome in Patients with Metastatic Colorectal Cancer Treated with Salvage Cetuximab/Panitumumab Monotherapy
Authors: Saridaki Zenia , Weidhaas Joanne B. , Lenz Heinz-Josef , Laurent-Puig Pierre , Jacobs Bart , De Schutter Jef , De Roock Wendy , Salzman David W. , Zhang Wu , Yang Dongyun , Pilati Camilla , Bouché Olivier , Piessevaux Hubert , Tejpar Sabine
Published: April 2023

Outcome and survival analysis according to KRAS 3'-UTR LCS6 genotypes and other clinical variables for the entire population.
Supplemental Table 1 from A let-7 microRNA-Binding Site Polymorphism in KRAS Predicts Improved Outcome in Patients with Metastatic Colorectal Cancer Treated with Salvage Cetuximab/Panitumumab Monotherapy
Authors: Saridaki Zenia , Weidhaas Joanne B. , Lenz Heinz-Josef , Laurent-Puig Pierre , Jacobs Bart , De Schutter Jef , De Roock Wendy , Salzman David W. , Zhang Wu , Yang Dongyun , Pilati Camilla , Bouché Olivier , Piessevaux Hubert , Tejpar Sabine
Published: April 2023

Patient characteristics.
Supplementary Figure Legend from Ganitumab (AMG 479) Inhibits IGF-II–Dependent Ovarian Cancer Growth and Potentiates Platinum-Based Chemotherapy
Authors: Beltran Pedro J. , Calzone Frank J. , Mitchell Petia , Chung Young-Ah , Cajulis Elaina , Moody Gordon , Belmontes Brian , Li Chi-Ming , Vonderfecht Steven , Velculescu Victor E. , Yang Guorong , Qi Jingwei , Slamon Dennis J. , Konecny Gottfried E.
Published: April 2023

PDF file - 46KB
Supplementary Figures 1 - 2 from Bortezomib-Induced Unfolded Protein Response Increases Oncolytic HSV-1 Replication Resulting in Synergistic Antitumor Effects
Authors: Yoo Ji Young , Hurwitz Brian S. , Bolyard Chelsea , Yu Jun-Ge , Zhang Jianying , Selvendiran Karuppaiyah , Rath Kellie S. , He Shun , Bailey Zachary , Eaves David , Cripe Timothy P. , Parris Deborah S. , Caligiuri Michael A. , Yu Jianhua , Old Matthew , Kaur Balveen
Published: April 2023

PDF file - 198KB, Supplementary Figure S1. Combinatorial treatment with bortezomib and oHSV1716 induce synergistic cell killing against S462TY malignant peripheral nerve sheath tumor (MPNST) cell. Supplementary Figure S2. Induction of ER stress and unfolded protein response (UPR) in CAL27 head and neck cancer cells treated with bortezomib.
Supplementary Tables S1-3 from Cyclin-Dependent Kinase Inhibitor AT7519 as a Potential Drug for MYCN-Dependent Neuroblastoma
Authors: Dolman M. Emmy M. , Poon Evon , Ebus Marli E. , den Hartog Ilona J.M. , van Noesel Carel J.M. , Jamin Yann , Hallsworth Albert , Robinson Simon P. , Petrie Kevin , Sparidans Rolf W. , Kok Robbert J. , Versteeg Rogier , Caron Huib N. , Chesler Louis , Molenaar Jan J.
Published: April 2023

Supplementary Tables S1-3. Table S1. IC25/50/75 and LC50 values of AT7519 for MYCN-amplified and non-MYCN-amplified neuroblastoma cell lines and cell seeding densities used to perform MTT cell proliferation assays (96-well plates). IC25/50/75 and LC50 values are derived from dose-response curves. Table S2. In vitro effects on sub-G1 induction and cell cycle progression in MYCN-amplified versus non-MYCN-amplified neuroblastoma cell lines after 72 h treatment with AT7519. Values represent the average percentage of cells in sub-G1, G1, S and G2 +/- SD. Table S3. Pharmacokinetic parameters derived from plasma disappearance and tumour accumulation curves after intraperitoneal administration of AT7519 to mice bearing MYCN-amplified AMC711T neuroblastoma xenografts.
Supplementary Table 1 from KRAS Codon 12 and 13 Mutations in Relation to Disease-Free Survival in BRAF–Wild-Type Stage III Colon Cancers from an Adjuvant Chemotherapy Trial (N0147 Alliance)
Authors: Yoon Harry H. , Tougeron David , Shi Qian , Alberts Steven R. , Mahoney Michelle R. , Nelson Garth D. , Nair Suresh G. , Thibodeau Stephen N. , Goldberg Richard M. , Sargent Daniel J. , Sinicrope Frank A.
Published: April 2023

PDF file - 81KB, Table S1. Multivariable logistic regression models showing the association of clinicopathologic and molecular characteristics with KRAS codon 12 or 13 mutation status in 2,478 BRAF-wild type stage III colon cancers.
Supplementary Figure Legend from KRAS Codon 12 and 13 Mutations in Relation to Disease-Free Survival in BRAF–Wild-Type Stage III Colon Cancers from an Adjuvant Chemotherapy Trial (N0147 Alliance)
Authors: Yoon Harry H. , Tougeron David , Shi Qian , Alberts Steven R. , Mahoney Michelle R. , Nelson Garth D. , Nair Suresh G. , Thibodeau Stephen N. , Goldberg Richard M. , Sargent Daniel J. , Sinicrope Frank A.
Published: April 2023

PDF file - 69KB
Supplementary Fig. S1 from Caffeine and Caffeic Acid Inhibit Growth and Modify Estrogen Receptor and Insulin-like Growth Factor I Receptor Levels in Human Breast Cancer
Authors: Rosendahl Ann H. , Perks Claire M. , Zeng Li , Markkula Andrea , Simonsson Maria , Rose Carsten , Ingvar Christian , Holly Jeff M.P. , Jernström Helena
Published: April 2023

Supplementary Fig. S1. Effect by caffeine or caffeic acid on apoptotic mediators
Data Supplement from Phase II Study of Single-Agent Orteronel (TAK-700) in Patients with Nonmetastatic Castration-Resistant Prostate Cancer and Rising Prostate-Specific Antigen
Authors: Hussain Maha , Corn Paul G. , Michaelson M. Dror , Hammers Hans J. , Alumkal Joshi J. , Ryan Charles J. , Bruce Justine Y. , Moran Susan , Lee Shih-Yuan , Lin H. Mark , George Daniel J.
Published: April 2023

Supplementary Table S1- Number of patients with 1-4 and {greater than or equal to}5 CTCs per 7.5mL of whole blood at baseline, and at 3, 6 and 12 months. Supplementary Table S2- Biochemical markers of bone turnover and bone mineral density (BMD).
Data Supplement from Demethylating Drugs as Novel Analgesics for Cancer Pain
Authors: Viet Chi T. , Dang Dongmin , Ye Yi , Ono Kentaro , Campbell Ronald R. , Schmidt Brian L.
Published: April 2023

Supplementary Figure S2. (a) Mechanical threshold of mice transduced with Ad-OPRM1 was significantly higher than the control, indicating lower mechanical allodynia (*p<0.05, ***p<0.001, with treatment as the main effect, see Supplementary Table S3 for statistical analysis). (b) Thermal threshold of mice transduced with Ad-OPRM1 was significant higher than control (***p<0.001, with treatment as the main effect). (c) Bar graph shows beta-endorphin concentration in supernatant from WM-164 transduced with either Ad-OPRM1 or Ad-GFP at 100 MOI. WM-164 cells transduced with Ad-OPRM1 secreted significantly more beta-endorphin than control cells (***p<0.001, Student's t test).
Data Supplement from Phase I Expansion and Pharmacodynamic Study of the Oral MEK Inhibitor RO4987655 (CH4987655) in Selected Patients with Advanced Cancer with RAS–RAF Mutations
Authors: Zimmer Lisa , Barlesi Fabrice , Martinez-Garcia Maria , Dieras Veronique , Schellens Jan H.M. , Spano Jean-Philippe , Middleton Mark R. , Calvo Emiliano , Paz-Ares Luiz , Larkin James , Pacey Simon , Venturi Miro , Kraeber-Bodéré Françoise , Tessier Jean J.L. , Eberhardt Wilfried Ernst Erich , Paques Michel , Guarin Ernesto , Meresse Valerie , Soria Jean-Charles
Published: April 2023

Supplementary Figure 2. Case study: 64-year old female with BRAF V600-mutant melanoma (A) Immunhistochemistry for Ki67 expression showing a reduction between baseline and cycle1/day15 in lymph node biopsies (B) Immunhistochemistry for pERK expression showing a reduction between baseline and cycle5/day1 in lymph node biopsies (C) FDG-PET uptake at baseline (D) FDG-PET metabolic partial response at day 15 of cycle 1 (E) CT scan images at baseline (F) CT scan images at day 1 of cycle 5 show a 80% reduction in target lesion size, indicating partial response
Supplementary Figure Legends 57 from Identification of Galanin and Its Receptor GalR1 as Novel Determinants of Resistance to Chemotherapy and Potential Biomarkers in Colorectal Cancer
Authors: Stevenson Leanne , Allen Wendy L. , Turkington Richard , Jithesh Puthen V. , Proutski Irina , Stewart Gail , Lenz Heinz-Josef , Van Schaeybroeck Sandra , Longley Daniel B. , Johnston Patrick G.
Published: April 2023

PDF file - 77K
Supplemental Table S4 from A Three-microRNA Signature Predicts Responses to Platinum-Based Doublet Chemotherapy in Patients with Lung Adenocarcinoma
Authors: Saito Motonobu , Shiraishi Kouya , Matsumoto Kenji , Schetter Aaron J. , Ogata-Kawata Hiroko , Tsuchiya Naoto , Kunitoh Hideo , Nokihara Hiroshi , Watanabe Shun-ichi , Tsuta Koji , Kumamoto Kensuke , Takenoshita Seiichi , Yokota Jun , Harris Curtis C. , Kohno Takashi
Published: April 2023

The prediction value of the three-miRNA signature.
Supplemental Table S3 from A Three-microRNA Signature Predicts Responses to Platinum-Based Doublet Chemotherapy in Patients with Lung Adenocarcinoma
Authors: Saito Motonobu , Shiraishi Kouya , Matsumoto Kenji , Schetter Aaron J. , Ogata-Kawata Hiroko , Tsuchiya Naoto , Kunitoh Hideo , Nokihara Hiroshi , Watanabe Shun-ichi , Tsuta Koji , Kumamoto Kensuke , Takenoshita Seiichi , Yokota Jun , Harris Curtis C. , Kohno Takashi
Published: April 2023

Differentially expressed 12 miRNAs in responders compared with its non-responders.
Supplementary Figure Legend from Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen–Specific T-cell Immunity in Head and Neck Cancer Patients
Authors: Srivastava Raghvendra M. , Lee Steve C. , Andrade Filho Pedro A. , Lord Christopher A. , Jie Hyun-Bae , Davidson H. Carter , López-Albaitero Andrés , Gibson Sandra P. , Gooding William E. , Ferrone Soldano , Ferris Robert L.
Published: April 2023

PDF file - 84K
Supplementary Figure 1 from Cetuximab-Activated Natural Killer and Dendritic Cells Collaborate to Trigger Tumor Antigen–Specific T-cell Immunity in Head and Neck Cancer Patients
Authors: Srivastava Raghvendra M. , Lee Steve C. , Andrade Filho Pedro A. , Lord Christopher A. , Jie Hyun-Bae , Davidson H. Carter , López-Albaitero Andrés , Gibson Sandra P. , Gooding William E. , Ferrone Soldano , Ferris Robert L.
Published: April 2023

PDF file - 45K, In-vitro expansion of EGFR-specific CTL in the presence of NK cells.