bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH KUALITAS LAYANAN DAN HARGA TERHADAP TINGKAT KEPUASAN KONSUMEN JASA TRANSPORTASI OJEK ONLINE MUSLIMAH DI KOTA SAMARINDA
Authors: Susanti Dian , Mahrus Moh , Pratiwi Angrum , Yanti Dharma
Published: July 2023

Latar belakang ini adalah Kota Samarinda  yang masyarakatnya mayoritas beragama Islam serta banyak akhwat nya (perempuan), hanya saja tidak semua masyarakat untuk menggunakan jasa transportasi ojek online muslimah dalam bepergian karena masalah keamanan dikarenakan ojek ini dikendarai oleh seorang perempuan. Maka dari itu penulis mengambil studi kasus di Kota Samarinda karena saat ini di Samarinda sedang marak ojek online yang di kendarai oleh perempuan.Sedangkan tujuan dari penelitian ini yaitu untuk mengetahui pengaruh kualitas layanan terhadap kepuasan konsumenjasa transportasi ojek online muslimah di Kota Samarinda, pengaruh harga terhadap kepuasan konsumen jasa transportasi ojek online muslimah di Kota Samarinda, dan mengetahui variabel mana yang lebih besar berpengaruh terhadap kepuasan konsumenjasa transportasi ojek online muslimah di Kota Samarinda.Setelah dilakukan tinjauan pustaka maupun lapangan dan penyusunan hipotesis, data dalam penelitian ini dikumpulkan melalui penyebaran kuesioner kepada 87 orang yang pernah menggunakan transportasi ojek online muslimah di kota Samarinda sebagai sampel penelitian. Teknik pengambilan data yang digunakan adalah melalui wawancara, dokumentasi dan penyebaran angket/kuisioner.Metode analisis data yang digunakan adalah analisis kuantitatif yaitu uji validitas dan reliabilitas, uji asumsi klasik, analisis regresi linear berganda, uji t dan uji F serta koefisien determinasi.Berdasarkan analisis data, hasil penelitian menunjukkan bahwa indikator-indikator pada pada penelitian ini bersifat valid dan reliabel.Pada uji asumsi klasik data berdistribusi normal, linier, tidak terjadi heteroskedastisitas, autokorelasi dan multikolinieritas. Pada uji hipotesis semua variabel independen (kualitas layanan dan harga) berpengaruh positif dan signifikan terhadap variabel dependen (tingkat kepuasan konsumen).Selain itu hasil hipotesis juga menunjukan kualitas layanan dan harga berpengaruh secara simultan terhadap tingkat kepuasan konsumen.
Analisis Strategi Penghimpunan Dana Bantuan Sosial Yayasan Damai Aqsha Samarinda Pada Masa Sebelum dan Saat Pandemi
Authors: Ramadhan Syahrul , Alfitri Alfitri , Rahmatullah Nur
Published: July 2023

The condition of the Aqsa Damai Foundation, whose purpose is to contribute to outside Indonesia, is still able to exist despite the Covid-19 pandemic. The study aims to understand the strategy of the Aqha Samarinda Damai Foundation in conessllecting social assistance funds before and during the pandemic, as well as knowing the influencing factors in implementing strategies for collecting social assistance funds during the pandemic.In this study, the research used qualitative research method using descriptive research. This is because the data collected is in the form of words, pictures and not numbers. Data collection techniques using observation, interviews and documentation. And the data analysis techniques used are data reduction, data presentation and conclusion drawing.The results of this study indicate that the strategy for collecting social assistance funds is in the form of Direct fundraising and Indirect fundraising. The Direct Fundraising methods implemented include Daulah Sheikh/Sheikho, Cheerful Fairy Tales, Charity Concerts, Watch Together, Boar Tunas Collection, Commitment Cards, Establishment of Outlets, work partners, and account transfers, while the Indirect Fundraising method is through WhatsApp, Instagram , facebook, tiktok and twitter. Supporting factors for the implementation of the various prepared strategies are Indonesia's attitude of always helping Palestine, achieving feedback from the activities carried out, quality services and appreciation for donors, educated people, professional human resources, quality amil quality, strategic location of institutions and innovation. from the institution. Meanwhile, the inhibiting factors that affect the fundraising strategy are the COVID-19 pandemic, the difficulty of obtaining activity permits and innovations that must always be prepared. Keywords: Strategy, Collection, Social Assistance Fund, Pandemi.
Meli Dwi Fadilah Pengembangan Usaha Ekspor Lidi Nipah BUMDes Bina Mandiri Muara Badak Dalam Meningkatkan Pendapatan Masyarakat Desa Muara Badak Ulu
Authors: Fadilah Meli Dwi , Parno Parno , Noni Yovanda
Published: July 2023

This research is based on the background that the economic income of the people of Muara Badak Ulu Village is a micro-scale community economic activity that can be managed by the community and the village government. Factors that influence the increase in economic income of the people of Muara Badak Ulu Village are the development model of the export business of lidi nipah BUMDes fostered independently, the economic income of the community and the obstacles of SME lidi nipah which make it increase the income of the people of Muara Badak Ulu Village.This study aims to determine the development of export businesses for independent-assisted BUMDes in increasing the economic income of the people of Muara Badak Ulu Village. This type of research is descriptive qualitative. The methods used in the study are observation, wawancaea, and documentation. The object in this study is bumdes Bina Mandiri in Muara Badak Ulu Village.

The results showed that the model of developing the lidi nipah export business of BUMDes Bina Mandiri in Muara Badak Ulu Village can be seen from the form of success in helping to improve the economic standards of the community in forming a lidi nipah work program consisting of aspects of competition, resources, technology, institutions, and financial institutions. Judging from the economic income of the community in the business of lidi nipah business, it is useful to increase the standard of living of the community where the welfare of the community can provide world happiness and the happiness of the afterlife and be kept away from the evil of their creatures. Then the income generated can meet the needs of his daily life with a profit of around Rp. 20,000,000 (Twenty Million Rupiah) per year. With exports in the form of making broomsticks, mats, and so on, as much as approximately 89 tons per year. The obstacles faced by smes are volatile due to bad weather that makes the palm trees and nipah trees fail to harvest. Therefore, BUMDes helps find nipah land in other villages that are ready to be harvested so that their business can run smoothly.

Keywords: Lidi Nipah Export Business Development Model, Community Economic Income, and Lidi Nipah SME Barriers
Pengaruh Lingkungan Kerja, Disiplin Kerja, Religiusitas dan Kompensasi Terhadap Kinerja Pegawai Badan Amil Zakat Nasional Provinsi Kalimantan Timur
Authors: Effendi Safu'an Mahfud , Mahrus Moh. , Hasbi Muhammad
Published: July 2023

Abstract

 

Quality human resources are a factor in supporting the company's success in achieving its goals. There need to be supporting factors, namely the work environment to make employees feel comfortable and safe at work, work discipline to provide a sense of responsibility to employees at work, religiosity to create employees who are obedient to the teachings of their religion, then compensation to provide employee welfare. This study aims to determine whether the work environment, work discipline, religiosity and compensation affect the performance of the employees of the National Amil Zakat Agency of East Kalimantan Province.  The type of research used is an associative research method with a quantitative collection strategy. This study uses primary data from observations, questionnaires, documentation, and interviews. The total population in this study was 19 respondents with a sampling technique, namely Saturated Sampling so that the total number of the population was used as the research sample. The analytical technique used in this study is to test the validity of the data, namely the validity and reliability test, then the classical assumption test, multiple linear regression test and hypothesis testing consisting of t-test and F-test and the coefficient of determination (R2) with SPSS 21 data processing. The results of the study, it was found that partially the work environment variable had a significant effect on employee performance with a significant value of 0,003 < 0,05, besides the work discipline variable had a significant effect on employee performance with significant value 0,049 < 0,05 and the religiosity variable had no significant effect on employee performance with significant value 0,0331 > 0,05 and the compensation variable did not significantly affect employee performance with significant value 0,700 > 0,05. then the results of the test calculation simultaneously obtained that the variables of work environment, work discipline, religiosity and compensation have a simultaneous effect on the performance of the employees of the National Amil Zakat Agency of East Kalimantan Provincewith significant value 0,000 < 0,05 . And the results of the coefficient of determination showed that the variables of work environment, work discipline, religiosity and compensation on employee performance in this study amounted to 71.0% while the remaining were influenced by other variables.

 

Keywords: Work Environment, Work Discipline, Religiosity, Compensation, Performance
Pengaruh Inflasi, Saham Syariah, Sukuk, Reksadana Syariah Dan Asuransi Syariah Terhadap Pertumbuhan Ekonomi Di Indonesia Tahun 2015-2022
Authors: Putra Dermawan Has , Shafa Shafa , Hamidy Anwaril
Published: July 2023

As a developing country, Indonesia needs qualified economic instruments to increase national economic growth by at least 7%. On the other hand, Indonesia is one of the nations with the most advanced Islamic economy. It an excellent opportunity for Indonesia to enhance national economic growth through Islamic Stocks, Sukuk, Islamic Mutual Funds, and Islamic Insurance. However, Indonesia has not taken full advantage of these conditions, as the GDP has stagnated at 5% for the past eight years. In addition, several other factors, such as inflation, might affect national economic growth. This research aimed to determine the effect of inflation, Islamic stocks, Sukuk, Islamic mutual funds, and Islamic insurance on Indonesia’s economic growth in 2015-2022. This research employed quantitative methods. The data was collected using the Time Series technique in 2015-2022, which comprised 95 data. The data were analyzed by descriptive statistics, classical assumption test and multiple linear regression with the SPSS version 26. Partially, the result indicates that inflation did not significantly affect Indonesia’s economic growth. Islamic stocks significantly affected Indonesia’s economic growth. Sukuk significantly affected Indonesia’s economic growth. Islamic mutual funds did not significantly affect Indonesia’s economic growth. Islamic insurance significantly affected Indonesia’s economic growth. Simultaneously, inflation, Islamic stocks, sukuk, Islamic mutual funds and Islamic insurance significantly affected Indonesia’s economic growth.
EL DERECHO DE OCUPACIÓN EFECTIVA EN LOS CONTRATOS DE TRABAJO DE FUTBOLISTAS PROFESIONALES.
Authors: E. Gerbaudo Germán
Published: July 2023

En diferentes trabajos señalamos que la relación que se entablaba entre un futbolista profesional y la entidad deportiva a la que presta sus servicios es un contrato de trabajo con características especiales. De esa relación laboral emergen diversos derechos y obligaciones para cada uno de los sujetos de la misma, los que pueden calificarse como “derecho-deber” debido a que a cada obligación de una de las partes le corresponde un derecho de parte de la otra y viceversa. El primer deber que asume el empleador al celebrar el contrato de trabajo es el de ocupación efectiva. Se trata de un deber del empleador que genera un correlativo derecho a favor del futbolista. El club empleador debe garantizarle al trabajador su ocupación efectiva en las condiciones legales y contractuales pactadas.
URBANIZAÇÃO E DESASTRES: OCUPAÇÃO DAS ÁREAS DE RISCOS EM TERESINA, PIAUÍ
Authors: Rocha João Víctor Vieira , Barbosa Pereira Patricia
Published: July 2023

Assim como ocorrido em outros grandes centros urbanos brasileiros, o processo de urbanização de Teresina-PI é marcado pela desordenada expansão da ocupação e uso do solo. O presente ensaio teórico tem como objetivo conhecer o processo de urbanização e ocupação irregular em áreas de risco no município em questão, uma vez que o mesmo apresenta níveis de degradação socioeconômicas e ambientais. Partindo de um arcabouço teórico-conceitual onde foram debatidos e compreendidos conceitos importantes para a construção da reflexão sobre prevenção de desastres, para então, buscar respostas que minimizem e ou previna os negativos impactos socioambientais que decorrem da ocupação das áreas de riscos. Visto que, as análises sobre a vulnerabilidade tornaram-se importantes instrumentos de estudo do espaço geográfico em questão, além de contribuir para o planejamento através de uma análise integrada envolvendo os aspectos sociais e ambientais. Os resultados encontrados constatam a fragilidade ambiental e a vulnerabilidade social presentes em várias zonas da região, principalmente nas planícies fluviais dos rios Parnaíba e Poti, onde se faz necessário um novo reordenamento e disciplinamento do espaço urbano.
AVALIAÇÃO DA QUALIDADE DA ÁGUA DA PRAIA DA LUA NO RIO NEGRO, MANAUS – AMAZONAS
Authors: Santos Marques Souza dos , Lima Alexandra Amaro de , Vital Ana Rosa Tundis , Nobre Arcos Adriano
Published: July 2023

A qualidade da água dos rios pode ser moldada pelos períodos sazonais locais, principalmente em eventos extremos, interferindo nas condições de balneabilidade, pois sua contaminação pode ocasionar problemas de saúde pública. A região norte é fortemente influenciada por períodos sazonais de secas e cheias, o que afeta anualmente a praia da Lua, localizada no rio Negro no Estado do Amazonas. Portanto, o objetivo do trabalho foi avaliar a qualidade da água da praia da Lua em diferentes períodos sazonais e temporais. Para avaliar a qualidade da água da praia fluvial, foram realizadas coletas em 2008 e 2015, compreendendo os dois períodos sazonais, usando parâmetros físicos, químicos e microbiológicos. No período seco, as variáveis limnológicas apresentam alterações nos seus valores, em especial os coliformes fecais em 2015. Sugerimos uma implantação de um programa contínuo de monitoramento os recursos hídricos locais, visando acompanhar a qualidade ambiental dos rios e igarapés de banham a cidade de Manaus, e que são utilizados diariamente pela população local e turistas para a prática de esporte e lazer.
USO DO GOOGLE EARTH ENGINE PARA DETERMINAÇÃO DE ILHAS DE CALOR NO MUNICÍPIO DE VILHENA/RO
Authors: Schulz Robson Campos , Azevedo Laise Santos , Guimarães Ricardo José de Paula Souza e
Published: July 2023

As mudanças climáticas globais são uma das grandes preocupações da atualidade e em se tratando de áreas urbanas, o aumento de temperatura é o fenômeno mais percebido. Este estudo teve como objetivo identificar a presença de ilhas de calor nos bairros de Vilhena/RO utilizando dados de sensoriamento remoto obtidos do produto do sensor MODIS/MOD11A2 (Temperatura do Dia e Noite), com 1 km de resolução espacial, utilizando o Google Earth Engine (GEE). Ao definir as zonas climáticas entre zonas urbanas e zona rural (áreas com maior remanescente de vegetação nativa) os resultados demonstraram que houve variação da intensidade das temperaturas diurnas nas diferentes zonas de calor, observando a conservação de valores mais elevados na área urbana. Na análise da variação de temperatura entre os bairros localizados na zona urbana observou-se que os bairros com maior média de temperatura apresentam como característica maior ocupação residencial e comercial. Desta forma foi possível confirmar os efeitos das construções urbanas na temperatura da superfície, o que demonstra a necessidade de intervenção de mitigação nas áreas que estão sofrendo com a presença desse fenômeno, por meio de medidas como a promoção da ventilação urbana, melhor planejamento da distribuição das construções urbanas bem como utilização de materiais de recobrimento frios, arborização, ampliação e preservação de parques e áreas verdes e conservação de corpos d´água.
GEOGRAFIA E EXISTÊNCIA NA OBRA O PEQUENO PRÍNCIPE
Authors: Ramos da Silva Felipe Kevin
Published: July 2023

O presente artigo é uma tentativa de demonstrar a complexidade geográfica presente no pensamento do aviador e escritor francês Antoine de Saint-Exupéry (1900-1944), tendo como ícone de reflexão a obra O Pequeno príncipe (Le Petit Prince), de 1943. Neste voo, se reconhece essa famosa literatura enquanto obra filosófica que muito tem a contribuir para o pensamento geográfico enquanto linguagem própria de quem habita. Metodologicamente, adota-se uma análise dialógica, onde não há, necessariamente, uma ordem de leitura linear, mas um movimento de ida e volta a fim de verificar uma grafia existencial que perpassa por todas geonarrativas da obra. Para este voo epistemológico, convida-se pensadores como Nietzsche, Heidegger, Merleau-Ponty em seus diferentes pontos de reflexão a caminho do desvelamento do ser-geográfico presente na obra central deste ensaio.
CRESCIMENTO URBANO DE SINOP – MT ENTRE OS ANOS DE 2000 E 2020 E A RELAÇÃO ENTRE POPULAÇÃO, ATIVIDADES ECONÔMICAS E AGENTES PRODUTORES DO ESPAÇO URBANO
Authors: Lima Andrieli Caroline , Palmisano Angelo
Published: July 2023

A cidade de Sinop localizada na região norte do estado de Mato Grosso tem sua base econômica consolidada na prestação de serviços, indústria e comércio para atender um conjunto de cidades vizinhas. Sua atuação como núcleo regional notadamente reflete em seu crescimento econômico, demográfico e urbano. Esta pesquisa teve por objetivo mapear as áreas urbanizadas entre os anos de 2000 e 2020 e compreender a influência das atividades econômicas no processo de produção do espaço. Como metodologia foi adotado um procedimento quantitativo, por meio de consulta em bases de dados bibliográficos, cartográficos, estatísticos e análise da legislação pertinente objetivando identificar a evolução urbana e crescimento populacional no período analisado. Foi realizada uma visita de campo a cidade a fim de buscar informações complementares as já obtidas e realizar o registro registros fotográficos, após a obtenção dos dados esses foram analisados e tabulados. Os resultados evidenciaram a interação dos agentes de produção do espaço no processo de urbanização de Sinop, a partir dos setores imobiliários, fundiários e econômicos que contribuíram de forma significativa para estruturação do urbano e o surgimento de novos parcelamentos.
EXEQUIBILIDADE DA AGRICULTURA URBANA PARA AS COMUNIDADES RESIDENTES DAS ÁREAS DE RISCO
Authors: Alves Gomes de Almeida Ana Carla , Brito da Cruz Maria Lúcia
Published: July 2023

A Agricultura Urbana (AU) caracteriza-se pelo cultivo de espécies vegetais de valor alimentar, medicinal, ornamental e a criação de pequenos e médios animais na área urbana. Algumas cidades têm adotado a AU como uma forma de uso e ocupação para as comunidades residentes das áreas de risco, o que tem gerado retorno socioeconômico às famílias em condições vulneráveis. Nesse contexto, o presente trabalho objetiva relatar acerca de algumas experiências de inserção da AU promovidas pelo poder público municipal de Fortaleza como o Projeto Hortas Sociais, e a nível nacional e internacional o relato das iniciativas de inserção da AU nesses ambientes vulneráveis. Soma-se a isso, demonstrar que através da governança territorial torna-se possível e viável inserir a agricultura urbana como mecanismo de reconfiguração das áreas de risco, transformando-os em espaços produtivos além de estimular o desenvolvimento da agricultura urbana na área de estudo. Para tanto, utilizou-se de levantamento bibliográfico e o trabalho de campo nas instalações do refeiro projeto, além da visita aos órgãos pertinentes. Os resultados enfatizam que é fundamental reproduzir e adaptar as experiências relatadas para promover a atividade de AU nos espaços livres das áreas de risco como mitigação contra os usos e ocupações indevidas. Conclui-se que através da efetivação da AU na política municipal, a atividade de agricultura urbana configura-se como uma alternativa que evita a ocupação irregular das áreas de risco e concomitantemente confere renda e alimentação aos pobres urbanos.
CIRCULAÇÃO INTER-REGIONAL NA CONSTRUÇÃO DA FORMAÇÃO TERRITORIAL BRASILEIRA
Authors: Ferreira da Silva Mariza , Silvestre de Albuquerque Edu , Lopes Diniz Filho Luis
Published: July 2023

A ideia da ausência de fluidez espacial nacional no Brasil até as primeiras décadas do período republicano é derivada da tese dos arquipélagos econômicos. Sem questionar a importância da ligação dessas economias regionais ao mercado mundial, destacamos as principais conexões sociais e econômicas estabelecidas entre essas regiões desde sua ocupação mais efetiva. Assim, acreditamos que os discursos do "atraso regional" e do “isolamento geográfico” visaram dar sustentação, sobretudo no período republicano, mas também no período imperial, a estratégias regionais de barganha política junto ao governo central e, ainda, mais recentemente, passaram a subsidiar algumas vertentes da teoria social crítica ao corroborarem a ideia de uma formação territorial arcaica.
Investigation of the Oil-Soluble Particulate Temporary Plugging Agent-Assisted Water Huff ‘n’ Puff Enhanced Oil Recovery in Tight Oil Reservoirs
Authors: Kang Shaofei , Pu Chunsheng , Wang Kai , Li Xu , Zhang Na , Yan Dong , Huang Feifei
Published: July 2023

Water huff ‘n’ puff is an effective enhanced oil recovery (EOR) technology for tight oil reservoirs. However, the oil production of horizontal wells declines seriously after several huff ‘n’ puff cycles, and a large amount of oil is still trapped in the reservoir due to the heterogeneity of fracturing sections. The temporary plugging agent had been used for plugging high-permeability areas and thus diverting the following fluid into small permeability areas. It would improve the sweep efficiency of flooding fluid, enhancing oil recovery. However, the use of the oil-soluble particulate temporary plugging agent in the water huff ‘n’ puff application is barely reported. Therefore, the feasibility and influencing factors of oil-soluble particulate temporary plugging agent-assisted water huff ‘n’ puff (TAWHP) in enhancing oil recovery was investigated in this study. First, based on the evaluation of the performance of the oil-soluble particulate temporary plugging agent, the oil recovery of fractured core samples with different apertures for water huff ‘n’ puff and TAWHP was compared via the parallel-core experiment to verify the feasibility of TAWHP in enhancing oil recovery. The temporary plugging agent had good oil solubility, a low residual rate in the formation, and little damage to the formation. The oil recovery yielded by TAWHP was 5.17% higher than the traditional water huff ‘n’ puff process. More oil (i.e., about 1.71%) could be expelled from the fractured core samples with a small aperture. It indicated that the EOR performance yielded by water huff ‘n’ puff after several cycles could be enhanced by adding the oil-soluble particulate temporary plugging agent. After that, a mathematical model of TAWHP was established to investigate the effect of TAWHP parameters on EOR performance. The simulation results showed that the cumulative oil production increased with the increase in injection time of the temporary plugging agent solution, but the trend would level-off after 10 minutes. Moreover, as the diversion index increased, the effect of the injection rate on cumulative oil production gradually enhanced while the effect of the soaking time gradually weakened. Furthermore, the difference in cumulative oil production at different diversion indexes gradually increased as the huff ‘n’ puff cycle increased. This work could provide theoretical guidance for water huff ‘n’ puff enhancing oil recovery after several cycles.
Evaluation of the Efficiency of Nanomicellar Formulation of Fat-soluble Vitamins in Patients with Cystic Fibrosis: The Study Protocol for a Randomized Controlled Trial
Authors: Soleimanzadeh Mahsa , Talebi Saeedeh , Jaafari Mahmoud Reza , Sayedi Seyed Javad , Emadzadeh Maryam , Kianifar Hamid Reza
Published: July 2023

Background Cystic fibrosis is an inherited disease, which is caused by the CFTR protein defects due to mutations in the CFTR gene. Along with CFTR dysfunction, exocrine pancreatic insufficiency plays a key role in persistent fat malabsorption in CF patients; therefore, deficiency of fat-soluble vitamins (A, D, E, and K) is still a therapeutic challenge. Even with efficient pancreatic enzyme medication and CF-specific vitamins, many patients with CF have fat-soluble vitamins deficiency. The present study aims to evaluate the efficiency of nanomicelle formulation of fatsoluble vitamins in children with CF in order to achieve the appropriate serum levels of these vitamins.
Methods This prospective, single-blind control trial will be conducted at the Akbar Children’s Hospital in Mashhad, Iran. Patients with CF will be enrolled based on the eligibility criteria. The control group will receive the standard formulation of fat-soluble vitamins similar to the routine CF treatment and for the intervention group; the nanomicelle formulation of fat-soluble vitamins will be administrated for 3 months. The primary outcome of this study is the measurement of serum levels of fat-soluble vitamins. The secondary outcomes are clinical assessment by Shwachman-Kulczycki Score, anthropometrics, and quality of life. The outcomes will be assessed before and after 3 months.
Discussion Due to the persistent fat-soluble vitamin deficiency in CF disease, the nanomicelle formulation could be proposed as a new delivery method of fat-soluble vitamins in the treatment of cystic fibrosis.
Trial registration: Iranian Registry of Clinical Trials IRCT20220415054541N1. Registered on July 23,
2022.
Neuroborreliosis in a patient with Multiple Sclerosis on Ocrelizumab, a case report
Authors: Stamatellos Vasileios Periklis , Ulm Gunnar , Bronisch Boris , Barthel Almut , Stingele Robert
Published: July 2023

Introduction
Borreliosis is one of the most common vector-borne diseases in Europe that can affect the central nervous system.
Case Presentation
A 41-jears old female MS-Patient presented to our emergency department with Nausea and Headache that did not respond to painkillers. She was on Therapy with Ocrelizumab for two years without noticing disease activity. The results from both the lumbar puncture and laboratory tests confirmed an active infection with Borrelia burgdorferi. The patient was treated with Ceftriaxon intravenously for one week and Doxycyclin for another week with complete resolution of the symptoms.
Conclusion
We report the first case of neuroborreliosis in a patient under CD-20 depletion. Neuroborreliosis was treated with antibiotics with complete remission of the symptoms. The diagnosis of neuroborreliosis could be challenging in clinical practice and should be considered in MS patients with fatigue, especially in endemic areas.
Integrated photoreaction of sulfur dioxide (SO2) using Manganese based-TiO2 photocatalyst and choline chloride-ethlene glycol based eutectic ionic liquid
Authors: Chandran Krittika , Wilfred Cecilia Devi , Nawaz Rab , Kait Chong Fai , Zaid Hayyiratul Fatimah Mohd , Zabidi Noor Asmawati Mohd , Ullah Shafi
Published: July 2023

Due to its high toxicity and corrosiveness, sulfur dioxide (SO2) and its products including sulphite and sulphate a type of particulate matter present in air poses a threat to both human health and the environment as an atmospheric pollution. In the current study, an integrated photoreaction was developed for the removal of SO2 from the air stream. First, visible-light responsive TiO2 was synthesized via the precipitation method. Then Manganese (Mn) was additionally added to TiO2 using a wet impregnation process in order to further improve the photocatalyst's efficiency. The eutectic ionic liquid (EIL) based on choline chloride and ethylene glycol (ChCl:E.Gly) was used as an absorbent in the photoreaction. Based on the results of the photocatalytic activity, TiO2_0.1% showed the best performance, with an absorption capacity of 3.39 mmol SO2 equivalent/kg EIL, significantly increasing the SO2 absorption capacity and showing better photocatalytic performance. The photocatalytic process was optimized using central composite design (CCD) and response surface methodology (RSM). A significant integrated SO2 absorption efficiency of 84.4% was obtained at optimal conditions while using (0.25 g/L TiO2 loading, 50 mL EIL, and 0.10 wt% Mn) within 120 minutes of visible-light irradiation. The photoreaction was carried out in a laboratory-scale reactor, and it may be developed locally and would be suitable for industrial scale, providing an effective, affordable, and reliable SO2 collection system.
Blockade of Endothelin Receptors Mitigates SARS-CoV-2-induced Osteochondral Damage
Authors: Wen Chunyi , Au Man Ting , Ni Junguo , Tang Kaiming , Lauwers Marianne , Luo Cuiting , Zhu Lin , Jiang Tianshu , Chan Jasper , Yuan Shuofeng
Published: July 2023

Joint pain is a common post-acute COVID sequelae. Although pathological bone loss has been documented after SARS-CoV-2 infection, little is known about the damage to articular cartilage capping bone ends. Hereby, we characterise temporal changes of the bone-cartilage functional unit after SARS-CoV-2 infection in a golden Syrian hamster model. We observed cyst formation at osteochondral junction, chondrocyte senescence and subchondral bone loss in infected animals at 4 and 30 days post-infection. Endothelin signalling was upregulated with endothelial dysfunction and leakage of viral spike proteins to subchondral bone, triggering osteoclasts activation and chondrocytes senescence. Blockade of endothelin receptors using macitentan, an FDA-approved medication, alleviated cystic lesions and preserved chondrocyte number in acute phase of viral infection. Delayed macitentan treatment in post-acute infection phase still mitigated subchondral bone loss. Macitentan could also attenuate nociceptive pain induced by viral spike protein receptor binding domain injection in a mouse model. Collectively, macitentan is a repurposable drug candidate for treating SARS-CoV-2-induced joint damage and pain.
Urban noise does not affect cognitive performance in wild-caught Australian magpies
Authors: Connelly Farley , Johnsson Robin D. , Mulder Raoul A. , Hall Michelle L. , Lesku John A.
Published: July 2023

Exposure of wildlife to anthropogenic noise is associated with an array of disruptive effects. Research on this topic has focused on the behavioural and physiological responses of animals to noise, with little work investigating potential links to cognitive function. To fill this gap in our understanding, we explored how environmentally relevant urban noise affected the performance of wild-caught, city-living Australian magpies (Gymnorhina/Cracticus tibicen tyrannica) on a battery of cognitive tasks that included associative and reversal learning, inhibitory control, and spatial memory. Birds were housed and tested in a standardised laboratory environment; sample sizes varied across tasks (n = 7–9 birds). Tests were conducted over four weeks, during which all magpies were exposed to both an urban noise playback and a quiet control. Birds were presented with the entire test battery twice (in each treatment); however, tests were always performed without noise (playback muted during testing). Australian magpies performed similarly in both loud and quiet conditions on all four tasks. We also found that prior experience with the associative learning task had a strong effect on performance, with birds performing better on their second trial. Similar to previous findings on Australian magpies tested on the same tasks in the wild under noisy conditions, we could not find any disruptive effects on cognitive performance in a controlled experimental setting.
Bioinformatics analysis of immune-associated, chromatin-regulating genes as biomarkers of persistent atrial fibrillation
Authors: li han , Zhong Guo-Qiang
Published: July 2023

Aims: Atrial fibrillation (AF) is the most common arrhythmia associated with high morbidity and mortality.Chromatin regulators an analysis of the expression and immunological correlation of CRs in pAF and normal tissues was conducted to assess their potential as diagnostic biomarkers.
Methods: GSE31821, GSE411777, and GSE79768 datasets from the gene expression database, Gene Expression Omnibus, were combined into an integrated dataset for use as a training set. GSE2240 was used as a validation dataset. The merge function in R language was used to obtain the intersection of CRs and the included study data. The “Limma” software package was used to identify CR-related, differentially expressed genes (CR DEGs) in normal and pAF tissues, and the protein-protein interaction (PPI) network was used to search for hub genes. A logistic regression model was constructed based on these immHub genes to predict the occurrence of pAF.
Results: We observed increased expression of 48 genes, including 29 immune-related genes. Correlation of CR DEGS and the hub genes yielded six immHub genes (RBBP4, KAT7, KANSL2, ACTB, TRRAP, and KAT2B). The AUC values in the ROC analysis were 0.861 in the training dataset and 0.83 in the validation dataset.
Conclusions: Biomarkers such as RBBP4, KAT7, KANSL2, ACTB, TRRAP, and KAT2B may be associated with pAF, and relevant regulated microRNAs may be used as biomarkers or targets for the treatment of pAF. These findings could provide insights into the diagnosis, treatment, and prognosis evaluation of patients with pAF.
Seismic performance of self-centering multistage buckling restrained brace
Authors: Azizi Hesam , Eghbali Mahdi , Ahmadi Jamal
Published: July 2023

The all-steel self-centering multistage buckling restrained brace (SC-MBRB) with restrained cores consisting of different steel grades is an innovative hybrid system introduced to elevate the performance of conventional BRBs. This study submits a new configuration of SC-MBRB with cores made of high-strength (HSS), ultra-high-strength (UHSS), and low yield point (LYP) steels. A trilinear hysteretic model is proposed to simulate the cyclic behavior of SC-MBRBs. The seismic performance of SC-MBRB, including cyclic response, energy dissipation, re-centering property, and plastic deformations, was investigated by finite element (FE) analysis. Considering the specification of HSS and UHSS, including fracture behavior, low cycle fatigue, and ductility, the effect of different ratios of strength and cross-sections was investigated. Eventually, models with varying core lengths whose specifications were determined based on the Coffin-Manson relationship were examined. The results indicate that the introduced SC-MBRB has provided suitable seismic performance. Moreover, the trilinear kinematic hysteretic model could successfully predict the hysteretic behavior of SC-MBRB. Furthermore, applying maximum HSS core length with minimum LYP core length and combining S960 with the LYP100 provides the most reliable results.
The survival and clinical performance of anterior composite resin restorations and posterior indirect and cast restorations used to treat generalised tooth wear.
Authors: Malik Junaid , Shah Sachin , Hemmings Kenneth , Gulamali Akil , Malik Junaid
Published: July 2023

Objective
To evaluate the survival and clinical performance of various restorative materials used in the rehabilitation of generalised severe tooth wear within a UK NHS hospital and postgraduate institute.
Methods
The clinical performance of 527 restorations on 20 patients with generalised severe tooth wear was reviewed after mean period of 5 years. The anterior teeth were restored with direct composite resin and posterior teeth restored with indirect restorations. The study used modified United States Public Health Service (USPHS) criteria for the assessment of the restorations. Survival of the restorations was analysed using Kaplan-Meier survival curves, the log-rank test, and the Cox proportional hazards regression analysis.
Results
The sample included 20 participants (13 males, 7 females). The median age was 51.8 years (range 33–73 years). The results indicated that the median survival time for all restorations was 11.3 years when major failures were considered and 5.9 years for restorations when all types of failure were considered. A median survival time of 5.9 years for composite resin restorations and over 7 years for cast restorations was found when considering all failures. The composite resin restorations commonly failed as a result of fracture, wear and marginal discoloration. The factors that significantly influenced the survival of these restorations were the material used, aetiology, incisal relationship and tooth location. Compliance with post-treatment occlusal splint therapy was poor with 6/18 patients using the splints at the time of assessment. The biological complications associated with this treatment regime were rare. Patient satisfaction remained generally high, with greatest dissatisfaction related to treatment time.
Conclusions
The use of composite resin restorations with posterior indirect restorations to treat generalised severe tooth wear at an increased occlusal vertical dimension is a viable treatment modality with very few major complications.
Near Real-time Flood Inundation and Hazard Mapping of Baitarani River Basin using Google Earth Engine and SAR Imagery
Authors: Atchyuth Bobbili Aravind Sai , Swain Ratnakar , Das Pulakesh
Published: July 2023

Flood Inundation mapping and satellite imagery monitoring are critical and effective responses during flood events. Mapping of a flood using optical data is limited due to the unavailability of cloud-free images. Because of its capacity to penetrate clouds and operate in all kinds of weather, synthetic aperture radar is preferred for water inundation mapping. Flood mapping in Eastern India's Baitarani River Basin for 2018, 2019, 2020, 2021, and 2022 was performed in this study using Sentinel-1 imagery and Google Earth Engine with Otsu's algorithm. Different machine-learning algorithms were used to map the LULC of the study region. Dual polarizations VH and VV and their combinations VV×VH, VV + VH, VH-VV, VV-VH, VV/VH, and VH/VV were examined to identify non-water and water bodies. The Normalized Difference Water Index (NDWI) map derived from Sentinel-2 data validated the surface water inundation with 80% accuracy. The total inundated areas were identified as 440.3 km2 in 2018, 268.58 km2 in 2019, 178.40 km2 in 2020, 203.79 km2 in 2021, and 321.33 km2 in 2022, respectively. The overlap of flood maps on the LULC map indicated that flooding highly affected agriculture and urban areas in these years. The approach using the near-real-time Sentinel-1 SAR imagery and GEE platform can be operationalized for periodic flood mapping, helps develop flood control measures, and helps enhance flood management. The generated annual flood inundation maps are also useful for policy development, agriculture yield estimation, crop insurance framing, etc.
Repeated ketamine anesthesia during the neonatal period impairs hippocampal neurogenesis and long-term neurocognitive function by inhibiting Mfn2-mediated mitochondrial fusion in neural stem cells
Authors: Huang He , Wang Ning , Lin Jia-Tao , Qiu Yong-Kang , Wu Wei-Feng , Liu Qiang , Chen Chen , Wang Hai-Bi , Liu Yan-Ping , Dong Wei , Wan Jie , Zheng Hui , Zhou Cheng-Hua , Wu Yu-Qing
Published: July 2023

The mechanism of ketamine-induced neurotoxicity development remains elusive. Mitochondrial fusion/fission dynamics play a critical role in regulating neurogenesis. Therefore, this study was aimed to evaluate whether mitochondrial dynamics were involved in ketamine-induced impairment of neurogenesis in neonatal rats and long-term synaptic plasticity dysfunction. In the in vivo study, postnatal day 7 (PND-7) rats were intraperitoneally injected with 40 mg/kg ketamine four consecutive times at 1 h intervals. Our work revealed that ketamine induced mitochondrial fusion dysfunction in hippocampal NSCs by downregulating Mfn2 expression. In the in vitro study, ketamine treatment at 100 µM for 6 h significantly decreased the Mfn2 expression, and increased ROS generation, decreased mitochondrial membrane potential and ATP levels in cultured hippocampal NSCs. For the interventional study, lentivirus (LV) overexpressing Mfn2 (LV-Mfn2) or control LV vehicle was microinjected into the hippocampal dentate gyrus (DG) 4 days before ketamine administration. Targeted Mfn2 overexpression in the DG region could restore mitochondrial fusion in NSCs and reverse the inhibitory effect of ketamine on NSC proliferation and its faciliatory effect on neuronal differentiation. In addition, synaptic plasticity was evaluated by transmission electron microscopy, Golgi-Cox staining and long-term potentiation (LTP) recordings at 24 h after the end of the behavioral test. Our work revealed that preconditioning with LV-Mfn2 improved long-term cognitive dysfunction after repeated neonatal ketamine exposure by reversing the inhibitory effect of ketamine on synaptic plasticity in the hippocampal DG. The present findings demonstrated that Mfn2-mediated mitochondrial fusion dysfunction plays a critical role in the impairment of long-term neurocognitive function and synaptic plasticity caused by repeated neonatal ketamine exposure by interfering with hippocampal neurogenesis. Thus, Mfn2 might be a novel therapeutic target for the prevention of the developmental neurotoxicity of ketamine.
Treatment of degenerative scoliosis with short-segment decompression / fusion or long-segment decompression / fusion based on Berjano classification
Authors: Huang Shaolong , Zhou Chengqiang , Tang Zhongjian , Zhang Xu , Meng Xiao , Gu Jun , Xue Cheng , Tang Xianye
Published: July 2023

Obejective: The purpose of this study is to analyze the clinical and imaging results of the two surgical options of short fusion and long fusion according to Berjano classification.
Methods: We reviewed data from 92 patients who underwent spinal surgery at our hospital between January 2016 and January 2020. Patients with Berjano I or II were classified as having short segment fusion (SF group) and patients with Berjano III or IV were classified as having long segment fusion (LF group). The age, sex, main causes of treatment, number of fixed segments, clinical efficacy, radiological parameters, reoperation rate and other general conditions of the two groups were compared and analyzed.
Results： The number of fused segments in the LF group was 3.8 ± 0.8. The number of fused segments in SF group was 1.6±0.5. The recovery degree of Cobb angle, lumbar lordosis angle (LL) and sagittal vertical axis (SVA) in LF group was better than that in SF group at the last follow-up, but there was no significant difference in reoperation rate and patient satisfaction between the two groups (P>0.05). LF group had a higher incidence of perioperative complications (P<0.05), and there was no significant difference in the incidence of adjacent segment-related complications between the two groups (P = 0.3600).
Conclusion: The classification proposed by Berjano can well address the essential needs of ADS patients between symptoms and lateral bending correction, and patients' treatment satisfaction is high, which is a classification worthy of our consideration.
Multi-diverse metasurfaces for fast wide-angle sensing and through-wall imaging
Authors: Wong Hang , Liu Baiyang , Wu Jinyu , Zhang Qingfeng
Published: July 2023

Multi-diverse metasurfaces play a crucial role in enhancing the capacity of sensing, radar, imaging, and communication systems through electromagnetic wave manipulation across different diversity controls. Currently, the primary approach for achieving multidimensional manipulation is through the use of dynamic metasurfaces. However, this method has drawbacks when it comes to fast sensing and imaging because of limitations in pattern switching speed. To address this issue, we propose a novel microwave-to-millimeter-wave meta-atom that provides polarization and frequency diversities. The meta-atoms formed in an array with a disordered permutation enable a wide-angle near-field fast sensing for tracking the moving trajectory of an object. Moreover, employing a dispersion-engineered strategy to arrange the meta-atoms in an array allows for high-gain through-wall imaging, enabling the detection of a sparse object with varying shapes and positions. The achieved result confirms that the proposed technology paves the way for developing multi-diverse metasurfaces that possess fast detecting and through-wall imaging capabilities. This breakthrough creates opportunities for identifying previously unseen modalities, and opens up new possibilities in various applications such as autonomous vehicles, all-weather sensing in surveillance, and radar integrated communication systems in 6G and beyond.
Electrostatic wave interaction via asymmetric vector solitons as precursor to rogue wave formation in non-Maxwellian plasmas
Authors: Lazarides N. , Veldes Giorgos P. , Frantzeskakis D. J. , Kourakis Ioannis
Published: July 2023

An asymmetric pair of coupled nonlinear Schrödinger (CNLS) equations has been derived through a multiscale perturbation method applied to a plasma fluid model, in which two wavepackets of distinct (carrier) wavenumbers (k1 and k2) and amplitudes (Ψ1 and Ψ2) are allowed to co-propagate and interact. The original fluid model was set up for a non-magnetized plasma consisting of cold inertial ions evolving against a κ−distributed electron background in one dimension. The reduction procedure resulting in the CNLS equations has provided analytical expressions for the dispersion, self-modulation and cross-coupling coefficients in terms of the two carrier wavenumbers. These coefficients present no symmetry whatsoever, in the general case (of different wavenumbers).
The possibility for coupled envelope (vector soliton) solutions to occur has been investigated. Although the CNLS equations are asymmetric and non-integrable, in principle, the system admits various types of vector soliton solutions, physically representing nonlinear, localized electrostatic plasma modes, whose areas of existence is calculated on the wavenumbers’ parameter plane. The possibility for either bright (B) or dark (D) type excitations for either of the (2) waves provides four (4) combinations for the envelope pair (BB, BD, DB, DD), if a set of explicit criteria is satisfied. Moreover, the soliton parameters (maximum amplitude, width) are also calculated for each type of vector soliton solution, in its respective area of existence. The dependence of the vector soliton characteristics on the (two) carrier wavenumbers and on the spectral index κ characterizing the electron distribution has been explored. In certain cases, the (envelope) amplitude of one component may exceed its counterpart (second amplitude) by a factor 2.5 or higher, indicating that rogue waves (freak waves) may be formed due to modulational interactions among copropagating wavepackets.
As κ decreases from large values, modulational instability occurs in larger areas of the parameter plane(s) and with higher growth rates. The distribution of different types of vector solitons on the parameter plane(s) also varies significantly with decreasing κ, and in fact dramatically for κ between 3 and 2. Deviation from the Maxwell-Boltzmann picture therefore seems to favor modulational instability as a precursor to the formation of bright (predominantly) type envelope excitations and freak waves.