bluuebunny/crossref_metadata_2025 huggingface dataset:
Bio-convective viscoelastic Casson nanofluid flow over a stretching sheet in the presence of induced magnetic field with Cattaneo–Christov double diffusion
Authors: Ghosh Riya , Agbaje Titilayo M. , Mondal Sabyasachi , Shaw Sachin
Published: September 2021

Bio-convection is an important phenomenon which is described by hydrodynamic instability and pattern in suspension of biased swimming microorganisms. This hydrodynamics instability arises due to the coupling force between the motion of the micoorganisms and fluid flow. It becomes more significant when nanoparticles are immersed in the base fluid with non-Newtonian rheology. This study presents the bio-convection for a viscoelastic Casson nanofluid flow over a stretching sheet. The Cattaneo–Christov double diffusion, induced magnetic field, thermal radiation, heat generation, viscous dissipation and chemical reaction are taken into account. The boundary condition is enriched with the suction / injection and melting phenomena at the surface. Highly coupled nonlinear governing equations are simplified into a system of coupled ordinary differential equation by using proper similarity transformation. The spectral quasi-linearization method (SQLM) is used to solve the transformed governing equations numerically. Good agreement is observed with the numerical data investigated in the previous outstanding works. It is observed that the density of the motile microorganisms depends on Peclet number and bio-convective Lewis number. Bio-convection Rayleigh number increases the possibility of bio-convection in the system which results in the enhancement of temperature. It is also examined that temperature and concentration profiles increase with the Eckert number and thermophoresis parameter.
Stable foliations and CW-structure induced by a Morse–Smale gradient-like flow
Authors: Abbondandolo Alberto , Majer Pietro
Published: September 2021

We prove that a Morse–Smale gradient-like flow on a closed manifold has a “system of compatible invariant stable foliations” that is analogous to the object introduced by Palis and Smale in their proof of the structural stability of Morse–Smale diffeomorphisms and flows, but with finer regularity and geometric properties. We show how these invariant foliations can be used in order to give a self-contained proof of the well-known but quite delicate theorem stating that the unstable manifolds of a Morse–Smale gradient-like flow on a closed manifold [Formula: see text] are the open cells of a CW-decomposition of [Formula: see text].
Modeling unmanned aerial vehicle system for identifying foci of arboviral disease with monitoring system
Authors: Belém John David S. , Souza Hidalyn Theodory C. M. , Sobrinho Álvaro , Silva Lenardo Chaves E. , De Araujo Oliveira Helder Fernando
Published: September 2021

People who live in low-income and hard-to-reach regions are usually the most affected ones by high incidences of arboviral diseases, increasing morbidity and mortality rates, and public health costs. We present the modeling of hardware and software components of an unmanned aerial vehicle (UAV) system by mathematical tools, focusing on monitoring foci of arboviral diseases transmitted by Aedes aegypti mosquito, e.g., Zika, Chikungunya, and Dengue. We used restriction equations and the colored Petri nets formal modeling language to represent the flight dynamics and the software components of the system, respectively. We evaluated the specification of desired behaviors of the monitoring system using simulations and the model checking technique. The results showed the completeness and correctness of the specification. The design of such a system is challenging due to the potential risks to people and the environment. Therefore, this study provides insights into the development of an UAV system for such an application scenario. The monitoring system has the potential of improving the efficiency in identifying foci of arboviral diseases.
Modeling Non-Maturing Demand Deposits: A Proposed Methodology to Determining the Idiosyncratic Confidence Level Used for Separating Stable Deposit Volumes From Volatile Deposit Volumes
Authors: Döpp Sophie , Horovitz Andre , Szimayer Alexander
Published: September 2021

This paper aims to develop a methodology for the estimation of the idiosyncratic confidence level inherent within the process of determining the threshold of separation between volatile and stable deposit volumes. The idiosyncratic confidence level must be reflective of the institution’s specific risk preferences and liquidity risk management policies as anchored into the Principle 9 of the European Banking Authority and Basel Committee for Banking Supervision recommendations. We illustrate the proposed methodology by including liquidity constraints from the Basel III regulatory recommendations introduced in 2013. Furthermore, we point to other ancillary applications of such procedures in the financial risk management practice.
FOREIGN CAPITAL AND DOMESTIC FUNDING CONDITIONS: A MUNDELLIAN TRILEMMA PERSPECTIVE
Authors: STOJKOV ALEKSANDAR , WARIN THIERRY
Published: September 2021

This study investigates and evaluates the impact of global funding conditions on private sector credit growth and controlling for the Mundellian Trilemma configuration. We contribute to the empirical literature by investigating the role of other conditioning factors such as the size of economies and their level of economic development. The more specific research goals are as follows: (i) To explore the different Trilemma configurations by income group and size of the economies; (ii) to enrich international macroeconomics literature on the role of Trilemma configurations and countries’ idiosyncrasies in assessing the impact of global financial conditions; and (iii) to formulate policy-relevant conclusions. We argue that — when assessing the impact of global financial conditions — the exchange rate regime and financial openness matter and the size of the economy and its income level. The high volatility in gross and net international capital flows redefined many trilemma configurations in the Great Recession aftermath. Many countries decided to shield their financial markets by reducing the degree of financial openness and moving toward intermediate or middle-ground positions in their Trilemma configurations.
Design, Development, and Evaluation of a Cybersecurity, Privacy, and Digital Literacy Game for Tweens
Authors: Maqsood Sana , Chiasson Sonia
Published: September 2021

Tweens are avid users of digital media, which exposes them to various online threats. Teachers are primarily expected to teach children safe online behaviours, despite not necessarily having the required training or classroom tools to support this education. Using the theory of procedural rhetoric and established game design principles, we designed a classroom-based cybersecurity, privacy, and digital literacy game for tweens that has since been deployed to over 300 Canadian elementary schools. The game,
A Day in the Life of the JOs
, teaches children about 25 cybersecurity, privacy, and digital literacy topics and allows them to practice what they have learned in a simulated environment. We employed a user-centered design process to create the game, iteratively testing its design and effectiveness with children and teachers through five user studies (with a total of 63 child participants and 21 teachers). Our summative evaluation with children showed that the game improved their cybersecurity, privacy, and digital literacy knowledge and behavioural intent and was positively received by them. Our summative evaluation with teachers also showed positive results. Teachers liked that the game represented the authentic experiences of children on digital media and that it aligned with their curriculum requirements; they were interested in using it in their classrooms. In this article, we discuss our process and experience of designing a production quality game for children and provide evidence of its effectiveness with both children and teachers.
#PrettyFlyForAWiFi
Authors: Birnbach Simon , Baker Richard , Eberz Simon , Martinovic Ivan
Published: September 2021

Drones are becoming increasingly popular for hobbyists and recreational use. But with this surge in popularity comes increased risk to privacy as the technology makes it easy to spy on people in otherwise-private environments, such as an individual’s home. An attacker can fly a drone over fences and walls to observe the inside of a house, without having physical access. Existing drone detection systems require specialist hardware and expensive deployment efforts, making them inaccessible to the general public.

In this work, we present a drone detection system that requires minimal prior configuration and uses inexpensive commercial off-the-shelf hardware to detect drones that are carrying out privacy invasion attacks. We use a model of the attack structure to derive statistical metrics for movement and proximity that are then applied to received communications between a drone and its controller. We test our system in real-world experiments with two popular consumer drone models mounting privacy invasion attacks using a range of flight patterns. We are able both to detect the presence of a drone and to identify which phase of the privacy attack was in progress while being resistant to false positives from other mobile transmitters. For line-of-sight approaches using our kurtosis-based method, we are able to detect all drones at a distance of 6 m, with the majority of approaches detected at 25 m or farther from the target window without suffering false positives for stationary or mobile non-drone transmitters.
Asthma as a Developmental Disorder
Authors: Martinez Fernando D.
Published: September 2021

Asthma is the most common disorder in childhood, affecting six million children in the United States. Asthma is a heterogeneous disease, but most cases either start in early life or have their roots in events occurring in utero or during the preschool years. Protective or harmful exposures, including to environmental microbes, occurring during critical developmental windows determine patterns of immune responses that often persist for a lifetime. Air pollution, tobacco smoke, and prematurity can cause congenital airway narrowing, and newborns with decreased airway function are at risk for having asthma symptoms up to adulthood. Effects of environmental exposures are modified by common genetic variations and may also be mediated by prenatal changes in the epigenetic structure of the genome. Based on this evidence, we have postulated that asthma should be considered a developmental disorder, and this concept may be applicable to other chronic medical conditions affecting both children and adults.
The Biology of Aging in Insects: FromDrosophilato Other Insects and Back
Authors: Promislow Daniel E.L. , Flatt Thomas , Bonduriansky Russell
Published: September 2021

An enormous amount of work has been done on aging in Drosophila melanogaster, a classical genetic and molecular model system, but also in numerous other insects. However, these two extensive bodies of work remain poorly integrated to date. Studies in Drosophila often explore genetic, developmental, physiological, and nutrition-related aspects of aging in the lab, while studies in other insects often explore ecological, social, and somatic aspects of aging in both lab and natural populations. Alongside exciting genomic and molecular research advances in aging in Drosophila, many new studies have also been published on aging in various other insects, including studies on aging in natural populations of diverse species. However, no broad synthesis of these largely separate bodies of work has been attempted. In this review, we endeavor to synthesize these two semi-independent literatures to facilitate collaboration and foster the exchange of ideas and research tools. While lab studies of Drosophila have illuminated many fundamental aspects of senescence, the stunning diversity of aging patterns among insects, especially in the context of their rich ecology, remains vastlyunderstudied. Coupled with field studies and novel, more easily applicable molecular methods, this represents a major opportunity for deepening our understanding of the biology of aging in insects and beyond.
Attitudes, Habits, and Behavior Change
Authors: Verplanken Bas , Orbell Sheina
Published: September 2021

Efforts to guide peoples’ behavior toward environmental sustainability, good health, or new products have emphasized informational and attitude change strategies. There is evidence that changing attitudes leads to changes in behavior, yet this approach takes insufficient account of the nature and operation of habits, which form boundary conditions for attitude-directed interventions. Integration of research on attitudes and habits might enable investigators to identify when and how behavior change strategies will be most effective. How might attitudinally driven behavior change be consolidated into lasting habits? How do habits protect the individual against the vicissitudes of attitudes and temptations and promote goal achievement? How might attitudinal approaches aiming to change habits be improved by capitalizing on habit discontinuities and strategic planning? When and how might changing or creating habit architecture shape habits directly? A systematic approach to these questions might help move behavior change efforts from attitude change strategies to habit change strategies.
A task-based learning strategy in preclinical medical education
Authors: Shenoy Roopashree , Jain Animesh , K Bhagyalakshmi , Shirali Arun , Shetty Sneha B. , Ramakrishna Anand
Published: September 2021

Preclinical task-based learning (TskBL) is a simulated learning approach in which the focus for students is a real task done by a medical professional. TskBL includes standardized patient encounters and is helpful to provide early clinical exposure. Our study aimed at planning, implementing, and assessing TskBL among first-year medical students and comparing it to the conventional method of tutorials in the physiology MBBS curriculum. This is a nonequivalent group quasi-experimental study approved by the institutional ethics committee. TskBL was conducted for seven topics among first-year medical students of Kasturba Medical College, Mangalore for three academic years. Participants were divided into a TskBL group and a control group. Both groups attended the theory classes in physiology, practical sessions, and clinical examinations concerning the tasks. After this, the TskBL group underwent TskBL, and the control group underwent tutorials. Pretest and posttest assessments were conducted by using a multiple choice question (MCQ) test and objective structured clinical examinations (OSCEs).The mean TskBL scores for MCQ (exception: hypertension, myasthenia gravis, and chronic obstructive pulmonary disease) and OSCE (exception: anemia and hypertension) were significantly higher than the tutorial group. Pretest and posttest scores revealed significantly higher MCQ and OSCE scores for TskBL (exception: MCQ score for hypertension and chronic obstructive pulmonary disease). The tutorial group did not show a significant improvement in test scores for all the tasks. The TskBL strategy could be used for topics that are likely to be encountered by the students during clinical attachments. Small group teaching can include TskBL in preference to tutorials to provide early clinical exposure in medical schools.
Intravital assessment of precapillary pulmonary arterioles of type 1 diabetic mice shows oxidative damage and increased tone in response to NOS inhibition
Authors: Roberts Andrew M. , Moulana Nayeem Z. , Jagadapillai Rekha , Cai Lu , Gozal Evelyne
Published: September 2021

Diabetes pulmonary and microvascular consequences are well recognized but have not been characterized. We assessed lung microvascular changes in a live anesthetized mouse model of type 1 diabetes, using a novel intravital microscopy technique. Our results show new evidence that a diabetes-induced decrease in lung nitric oxide bioavailability underlies oxidative damage, enhanced platelet activation, and endothelial injury causing pulmonary microvascular dysfunction and altered vasoreactivity. These findings could provide novel strategies to prevent or reverse diabetes systemic consequences.
Peripheral chemoreflex activation and cardiac function during hypoxemia in near-term fetal sheep without placental compromise
Authors: Lantto Juulia , Erkinaro Tiina , Haapsamo Mervi , Huhta Heikki , Alanne Leena , Kokki Merja , Ohtonen Pasi , Bhide Amarnath , Acharya Ganesh , Räsänen Juha
Published: September 2021

During fetal hypoxemia with intact placental circulation, peripheral chemoreflex was activated, as demonstrated by an increase in the descending aorta blood pressure, pulmonary vasoconstriction, and an increase in retrograde diastolic AoI blood flow, while both ventricular cardiac outputs remained stable. However, perfusion pressure in the cerebral circulation decreased. These changes were seen even during prolonged hypoxemia when significant metabolic acidosis developed. Weight-indexed LVCO or AoI Net Flow ratio did not correlate with a drop in carotid artery blood pressure.
A Rare Disease Presenting Postpartum: Acute Fatty Liver of Pregnancy
Authors: Córdoba-Vives Sofía , Pérez-Rodríguez Patricia , Marín-Delgado Astrid , Matus-Vargas Miguel , Arias-González Adriana
Published: September 2021

Acute fatty liver of pregnancy is a rare but highly fatal disease affecting women most frequently during the third trimester of pregnancy or in the postpartum period. It is considered a diagnosis of exclusion and requires a timely diagnosis to avoid maternal mortality. We present the case of a 33-year-old primigravida who required an emergency cesarean section due to fetal bradycardia. On postoperative day one, the patient was noted jaundiced, oliguric, and hypoglycemic. Laboratory tests revealed important hepatic dysfunction, coagulopathy, and renal failure. She was admitted to the Intensive Care Unit with the suspicion of acute fatty liver of pregnancy. Plasma exchange was started on postoperative day 5 with major clinical and laboratory improvement. A transjugular hepatic biopsy confirmed the diagnosis. The patient had satisfactory evolution and was discharged 15 days after delivery. Acute fatty liver of pregnancy is a highly morbid disease that needs a high index of suspicion to be diagnosed. Admission to an Intensive Care Unit to ensure maximum supportive care is mandatory in this disease.
Application Effect of Case Management Mode Combined with ERAS in Elderly Patients with Hip Fracture
Authors: Peng Na , Li Jing
Published: September 2021

Objective. To explore the effect of the case management mode combined with enhanced recovery after surgery (ERAS) in elderly patients with hip fracture. Methods. A total of 102 elderly hip fracture patients admitted to our hospital from June 2018 to December 2019 were selected. The patients with hip fracture were divided into the control group (n = 51) and the observation group (n = 51) by the random number table method. The control group adopts the conventional nursing mode, and the observation group adopts the case management mode combined with ERAS. The bed activity time, hospitalization time, total hospitalization expenses, and the satisfaction of patients were observed. The numeric rating scale (NRS) was used to assess the patient’s pain before treatment and at 1, 3, and 5 days after treatment. The Harris score was used to assess the patient’s joint motor function before treatment and at the 8th week after treatment. The perioperative complications of the two groups were compared. Result. After treatment, the observation group was better than the control group in terms of out of bed activity time, hospitalization time, total hospitalization expenses, and the satisfaction of patients (

P
<
0.05

). Before treatment, there was no significant difference in NRS scores between the two groups (

P
>
0.05

). After treatment, the NRS scores of the two groups were lower than before treatment, and on days 1, 3, and 5 after treatment, the NRS scores of the observation group were lower than those of the control group (

P
<
0.05

). Before treatment, there was no difference in the Harris score between the two groups (

P
>
0.05

). At the 8th week after treatment, the Harris scores of the two groups were higher than those before treatment, and the Harris scores of the observation group were higher than those of the control group (

P
<
0.05

). The total incidence of perioperative complications in the observation group (4/51) was lower than that in the control group (13/51) (

P
<
0.05

). Conclusion. The application of the case management mode combined with ERAS nursing in elderly patients with hip fracture can improve the clinical symptoms of patients, improve the therapeutic effect, and reduce the occurrence of complications, which is worthy of clinical application.
The Sunk Cost and the Real Option Pricing Model
Authors: Li Songsong , Zhang Yinglong , Wang Xuefeng
Published: September 2021

Although the academic literature on real options has grown enormously over the past three decades, hitherto an accurate real option pricing model has not been developed for investment decision analyses. In this paper, we propose a real option pricing model based on sunk cost characteristics, which can estimate the value of real options more accurately. First, we explore the distinctive features that distinguish real options from financial options. The study shows that the distinguishing feature of the real options is the sunk cost, which does not exist in the financial options. Based on the sunk cost characteristic of real options, we find that the exercise conditions of real and financial options are different. Second, we introduce the sunk cost into the intrinsic value function of real options and establish a new real option pricing model. Finally, this paper also discusses the properties of the intrinsic value function and pricing model of real options. We find that the application of the Black–Scholes option pricing model will overestimate the value of real options.
Increased Circulating CD4+CXCR5+ Cells and IgG4 Levels in Patients with Myelodysplastic Syndrome with Autoimmune Diseases
Authors: Xiao Na , He Xin , Niu Haiyue , Yu Hong , Cui Ningbo , Li Hongzhao , Yan Li , Shao Zonghong , Xing Limin , Wang Huaquan
Published: September 2021

Objectives. Immune abnormalities play an important role in the pathogenesis and progression of myelodysplastic syndrome (MDS). Some patients with MDS have autoimmune diseases (AI). Follicular helper T (Tfh) cells help B cells produce antibodies. The role of Tfh in MDS with AI has not been studied. Methods. We enrolled 21 patients with MDS with AI and 21 patients with MDS without AI. The proportion of peripheral blood CD4+CXCR5+ cells and the PD1 expression on CD4+CXCR5+ cells were detected by flow cytometry. Serum levels of immunoglobulin G (IgG) and IgG4 were measured. The survival and progression of MDS to acute myeloid leukemia (AML) in MDS patients with or without AI were compared. Results. MDS with AI accounted for 19.6% of all MDS cases in our study. The overall response rate was 81% (17/21) in MDS patients with AI for the first-line treatment. The proportion of circulating CD4+CXCR5+ cells was increased, but the expression of PD1 was decreased in MDS patients with AI. Serum IgG4 levels were also increased in MDS patients with AI. The proportion of peripheral blood CD4+CXCR5+ cells and the level of serum IgG4 decreased after therapy, but the expression of PD1 increased. There were no differences in overall survival and progress to acute myeloid leukemia between MDS with AI and without AI groups. Conclusion. CD4+CXCR5+ cells and IgG4 levels increased in patients with MDS and AI.
[Retracted] Intelligent Simulation of Children’s Psychological Path Selection Based on Chaotic Neural Network Algorithm
Authors: Wang Yue
Published: September 2021

In recent years, there are many problems in the study of intelligent simulation of children’s psychological path selection, among which the main problem is to ignore the factors of children’s psychological path selection. Based on this, this paper studies the application of chaotic neural network algorithm in children’s mental path selection. First, an intelligent simulation model for children’s mental path selection based on chaotic neural network algorithm is established; second, it will combine the network based on different types of visual analysis strategies. The model is used to analyze the influencing factors of children in different regions in the choice of psychological paths. Finally, experiments are designed to verify the actual application effect of the simulation model. The results show that compared with the current mainstream intelligent simulation methods with iterative loop algorithms as the core, it adopts the intelligent simulation model based on the chaotic neural network algorithm has a good classification effect. It can effectively select the optimal psychological path according to the differences in children’s personality and can adaptively classify children in different regions, and the experimental results are accurate. Compared with the traditional method, it is improved by at least 37%.
Radiographic Features of Facial Cosmetic Material: Report of Two Cases
Authors: Alsufyani Noura A. , Alsufyani Mohammed A.
Published: September 2021

Recently, the use of noninvasive facial cosmetic procedures has been widely disseminated. In the face, cosmetic fillers, threads, and implants are used to reduce or delay the effects of aging or adjust facial defects caused by trauma or disease. The dentist or dental specialist may encounter these materials in the radiographic images of their patients. There are few reports in the dental literature describing the radiographic appearance of some materials along with the diseases they mimic. As the procedures and materials advance and evolve, dentists and dental specialists must be aware of their radiographic appearance to avoid errors in diagnosis. This is a report of two cases that include panoramic radiography and CBCT scan. Among these cases, there is an unusual appearance of a cosmetic filler due to a subperiosteal injection method. Moreover, it will discuss common types of cosmetic materials used in the face and their imaginological appearance. This is the key to dentists and dental specialists due to increasing use of facial cosmetic materials and a parallel increase in the use of cone beam CT and chances to encounter such findings.
Shock Transfer in Futures and Spot Markets: An Agent-Based Simulation Modelling Method
Authors: Zhou Xuan , Li Menggang
Published: September 2021

There have been heated debates about the role of stock index futures in the financial market, especially during the crash periods. In this paper, a multiagent spot-futures market model is developed to analyze the micromechanism of shock transfer across spot and futures markets. We assume that there are two stocks and one stock index futures contract in the spot-futures market. Agents are heterogeneous, including fundamentalists, chartists, noise traders, and arbitragers. The spot market and the futures market are linked by arbitragers. The simulation results show that our spot-futures market model can reproduce various important stylized facts, including the price co-movement between stock index prices and index futures prices and the fat-tailed distribution of the returns of risky assets and the basis. Further analysis shows that when we introduce an exogenous fundamental shock to one of the stocks, the backwardation phenomenon appears in the futures market and the shock is widespread across the whole market by means of index futures. Moreover, the backwardation gradually disappears when the number of arbitragers increases. Besides, when there are few arbitragers or when there are sufficient arbitragers, shocks cannot be transferred to other stocks via the futures market, while an intermediate level of arbitrage will amplify the shock transfer and hurt market stability. These findings underscore that arbitragers play an important role in spot-futures market interaction and shock transfer, and adequate arbitrage trading during crises may help eliminate the positive basis and halt the further spread of the crises.
Parametric Study of the Borehole Drilling in Jointed Rock Mass
Authors: Gao Yanan , Zhang Yudong , Zhang Zetian , Li Minghui , Sun Yingfeng , Lan Donghao , Gao Feng
Published: September 2021

Gas is associated with coal mining; it commonly exists in the coal seam. It is one of the major dangers during the production because its reaction between the coal masses may induce the gas-coal outburst as well as it being an expositive matter. The gas accident has caused a huge amount of property damage and casualties. Therefore, the primary precaution for coal mining is gas control. At present, drilling and extraction are the main approaches for gas accident prevention. After drilling, the ground pressure will be released; the gas which is in a free state or absorbed in the coal seam will be easy to extract as the migration channel is enhanced. Hence, one of the most concerned problems is the stress redistribution of the coal and rock mass around the borehole. In practical engineering, there are many joints distributed in the coal and rock strata, so it is necessary to investigate the effect of the drilling in the jointed coal and rock mass. In this paper, the boundary element model of the borehole in the jointed coal and rock mass is established to study the influence of joints on the stress and displacement field. The following results can be obtained. The number of joints has a significant effect on the maximum displacement of the coal and rock mass. The maximum displacement increases with the number of the joint. The position of the maximum displacement shifts from the boundary of the borehole to the far field. Meanwhile, it can be found that the displacement may reach a peak value when the joint angle is 30° and if the joint number is less than 4, and the maximum displacement may occur under the joint angle of 45° and if the joints number continuous increases. The von Mises stress has a trend of increasing with the number of joints when the joint angle is less than 30°, while it has a decreasing trend when the joint angle is larger than 30°. The max stress may occur at the joint angle of 15°. The maximum shear stress occurs mostly in the No. 4 joint and the No.7 joint. When the joint angle is 30°, the maximum shear stress occurs in the No. 3 joint and the No. 4 joint. The overlap of the position of the maximum von Mises stress or the maximum displacement with different joint angles or different numbers of joint leads to a reexploration of such positions. The position of the maximum von Mises stress and the maximum displacement

o

is relatively steady, which locates symmetrically around the borehole. The line between the points that behaves as the maximum von stress is approximately perpendicular to the joint direction.
Homology Groups in Warped Product Submanifolds in Hyperbolic Spaces
Authors: Li Yanlin , Ali Akram , Mofarreh Fatemah , Alluhaibi Nadia
Published: September 2021

In this paper, we show that if the Laplacian and gradient of the warping function of a compact warped product submanifold

Ω

p

+

q

in the hyperbolic space

ℍ

m

−
1

satisfy various extrinsic restrictions, then

Ω

p

+

q

has no stable integral currents, and its homology groups are trivial. Also, we prove that the fundamental group

π

1

Ω

p

+

q

is trivial. The restrictions are also extended to the eigenvalues of the warped function, the integral Ricci curvature, and the Hessian tensor. The results obtained in the present paper can be considered as generalizations of the Fu–Xu theorem in the framework of the compact warped product submanifold which has the minimal base manifold in the corresponding ambient manifolds.
Clinical and Genetic Characteristics of ABCC8 Nonneonatal Diabetes Mellitus: A Systematic Review
Authors: Li Meng , Han Xueyao , Ji Linong
Published: September 2021

Objectives. Diabetes mellitus (DM) is a major chronic metabolic disease in the world, and the prevalence has been increasing rapidly in recent years. The channel of KATP plays an important role in the regulation of insulin secretion. The variants in ABCC8 gene encoding the SUR1 subunit of KATP could cause a variety of phenotypes, including neonatal diabetes mellitus (ABCC8-NDM) and ABCC8-induced nonneonatal diabetes mellitus (ABCC8-NNDM). Since the features of ABCC8-NNDM have not been elucidated, this study is aimed at concluding the genetic features and clinical characteristics. Methods. We comprehensively reviewed the literature associated with ABCC8-NNDM in the following databases: MEDLINE, PubMed, and Web of Science to investigate the features of ABCC8-NNDM. Results. Based on a comprehensive literature search, we found that 87 probands with ABCC8-NNDM carried 71 ABCC8 genetic variant alleles, 24% of whom carried inactivating variants, 24% carried activating variants, and the remaining 52% carried activating or inactivating variants. Nine of these variants were confirmed to be activating or inactivating through functional studies, while four variants (p.R370S, p.E1506K, p.R1418H, and p.R1420H) were confirmed to be inactivating. The phenotypes of ABCC8-NNDM were variable and could also present with early hyperinsulinemia followed by reduced insulin secretion, progressing to diabetes later. They had a relatively high risk of microvascular complications and low prevalence of nervous disease, which is different from ABCC8-NDM. Conclusions. Genetic testing is essential for proper diagnosis and appropriate treatment for patients with ABCC8-NNDM. And further studies are required to determine the complex mechanism of the variants of ABCC8-NNDM.
Gastroprotective Effect of Myricetin on Ethanol-Induced Acute Gastric Injury in Rats
Authors: Park Hee-seon , Seo Chang-Seob , Baek Eun Bok , Rho Jin-hyung , Won Young-Suk , Kwun Hyo-jung
Published: September 2021

The flavonoid myricetin is abundant in vegetables and has various bioactive properties, including anti-inflammatory and antioxidative activities. In the present study, we explored the effects of myricetin on alcohol-induced gastric ulcer in a rat model. To induce gastric ulcer, absolute ethanol (5 mL/kg body weight) was orally administrated to each rat. The positive control and myricetin-treated groups were given oral doses of omeprazole (20 mg/kg) or myricetin (12 mg/kg), respectively, 1 hour prior to the administration of absolute alcohol. We found that pretreatment with myricetin significantly decreased alcohol-induced gastric ulcer, hemorrhage, hyperemia, and epithelial cell loss in the gastric mucosa. Myricetin pretreatment reduced the level of malondialdehyde (MDA) and increased that of total glutathione (GSSG/GSH) and superoxide dismutase (SOD) in gastric tissues. In addition, it elevated the expression levels of cyclooxygenase-1 (COX-1) and prostaglandin E2 (PGE2) and decreased the phosphorylation of nuclear factor kappa B (NF-κB). Together, these results indicate that myricetin effectively inhibits ethanol-induced acute gastric injury by preventing oxidative damage, stimulating PGE2 production, and inhibiting NF-κB activation. We suggest that myricetin may be an alternative treatment for gastric injury caused by alcohol intake.
Geometric Modeling of Rosa roxburghii Fruit Based on Three-Dimensional Point Cloud Reconstruction
Authors: Xie Zhiping , Lang Yancheng , Chen Luqi
Published: September 2021

Fruit three-dimensional (3D) model is crucial to estimating its geometrical and mechanical properties and improving the level of fruit mechanical processing. Considering the complex geometrical features and the required model accuracy, this paper proposed a 3D point cloud reconstruction method for the Rosa roxburghii fruit based on a three-dimensional laser scanner, including 3D point cloud generation, point cloud registration, fruit thorns segmentation, and 3D reconstruction. The 3D laser scanner was used to obtain the original 3D point cloud data of the Rosa roxburghii fruit, and then the fruit thorns data were removed by the segmentation algorithm combining the statistical outlier removal and radius outlier removal. By analyzing the effects of five-point cloud simplification methods, the optimal simplification method was determined. The Poisson reconstruction algorithm, the screened Poisson reconstruction algorithm, the greedy projection triangulation algorithm, and the Delaunay triangulation algorithm were utilized to reconstruct the fruit model. The number of model vertices, the number of facets, and the relative volume error were used to determine the best reconstruction algorithm. The results indicated that this model can better reconstruct the actual surface of Rosa roxburghii fruit. The method provides a reference for the related application.
MTH1 Inhibitor TH1579 Induces Oxidative DNA Damage and Mitotic Arrest in Acute Myeloid Leukemia
Authors: Sanjiv Kumar , Calderón-Montaño José Manuel , Pham Therese M. , Erkers Tom , Tsuber Viktoriia , Almlöf Ingrid , Höglund Andreas , Heshmati Yaser , Seashore-Ludlow Brinton , Nagesh Danda Akhilesh , Gad Helge , Wiita Elisee , Göktürk Camilla , Rasti Azita , Friedrich Stefanie , Centio Anders , Estruch Montserrat , Våtsveen Thea Kristin , Struyf Nona , Visnes Torkild , Scobie Martin , Koolmeister Tobias , Henriksson Martin , Wallner Olov , Sandvall Teresa , Lehmann Sören , Theilgaard-Mönch Kim , Garnett Mathew J. , Östling Päivi , Walfridsson Julian , Helleday Thomas , Warpman Berglund Ulrika
Published: September 2021

Acute myeloid leukemia (AML) is an aggressive hematologic malignancy, exhibiting high levels of reactive oxygen species (ROS). ROS levels have been suggested to drive leukemogenesis and is thus a potential novel target for treating AML. MTH1 prevents incorporation of oxidized nucleotides into the DNA to maintain genome integrity and is upregulated in many cancers. Here we demonstrate that hematologic cancers are highly sensitive to MTH1 inhibitor TH1579 (karonudib). A functional precision medicine ex vivo screen in primary AML bone marrow samples demonstrated a broad response profile of TH1579, independent of the genomic alteration of AML, resembling the response profile of the standard-of-care treatments cytarabine and doxorubicin. Furthermore, TH1579 killed primary human AML blast cells (CD45+) as well as chemotherapy resistance leukemic stem cells (CD45+Lin−CD34+CD38−), which are often responsible for AML progression. TH1579 killed AML cells by causing mitotic arrest, elevating intracellular ROS levels, and enhancing oxidative DNA damage. TH1579 showed a significant therapeutic window, was well tolerated in animals, and could be combined with standard-of-care treatments to further improve efficacy. TH1579 significantly improved survival in two different AML disease models in vivo. In conclusion, the preclinical data presented here support that TH1579 is a promising novel anticancer agent for AML, providing a rationale to investigate the clinical usefulness of TH1579 in AML in an ongoing clinical phase I trial.

Significance:

The MTH1 inhibitor TH1579 is a potential novel AML treatment, targeting both blasts and the pivotal leukemic stem cells while sparing normal bone marrow cells.
A Modified Nucleoside 6-Thio-2′-Deoxyguanosine Exhibits Antitumor Activity in Gliomas
Authors: Yu Shengnan , Wei Shiyou , Savani Milan , Lin Xiang , Du Kuang , Mender Ilgen , Siteni Silvia , Vasilopoulos Themistoklis , Reitman Zachary J. , Ku Yin , Wu Di , Liu Hao , Tian Meng , Chen Yaohui , Labrie Marilyne , Charbonneau Casey M. , Sugarman Eric , Bowie Michelle , Hariharan Seethalakshmi , Waitkus Matthew , Jiang Wen , McLendon Roger E. , Pan Edward , Khasraw Mustafa , Walsh Kyle M. , Lu Yiling , Herlyn Meenhard , Mills Gordon , Herbig Utz , Wei Zhi , Keir Stephen T. , Flaherty Keith , Liu Lunxu , Wu Kongming , Shay Jerry W. , Abdullah Kalil , Zhang Gao , Ashley David M.
Published: September 2021

Purpose:

To investigate the therapeutic role of a novel telomere-directed inhibitor, 6-thio-2′-deoxyguanosine (THIO) in gliomas both in vitro and in vivo.

Experimental Design:

A panel of human and mouse glioma cell lines was used to test therapeutic efficacy of THIO using cell viability assays, flow cytometric analyses, and immunofluorescence. Integrated analyses of RNA sequencing and reverse-phase protein array data revealed the potential antitumor mechanisms of THIO. Four patient-derived xenografts (PDX), two patient-derived organoids (PDO), and two xenografts of human glioma cell lines were used to further investigate the therapeutic efficacy of THIO.

Results:

THIO was effective in the majority of human and mouse glioma cell lines with no obvious toxicity against normal astrocytes. THIO as a monotherapy demonstrated efficacy in three glioma cell lines that had acquired resistance to temozolomide. In addition, THIO showed efficacy in four human glioma cell lines grown as neurospheres by inducing apoptotic cell death. Mechanistically, THIO induced telomeric DNA damage not only in glioma cell lines but also in PDX tumor specimens. Integrated computational analyses of transcriptomic and proteomic data indicated that THIO significantly inhibited cell invasion, stem cell, and proliferation pathways while triggering DNA damage and apoptosis. Importantly, THIO significantly decreased tumor proliferation in two PDO models and reduced the tumor size of a glioblastoma xenograft and a PDX model.

Conclusions:

The current study established the therapeutic role of THIO in primary and recurrent gliomas and revealed the acute induction of telomeric DNA damage as a primary antitumor mechanism of THIO in gliomas.
Transglutaminase 2 Maintains Hepatocyte Growth Factor Signaling to Enhance the Cancer Cell Phenotype
Authors: Chen Xi , Adhikary Gautam , Shrestha Suruchi , Xu Wen , Keillor Jeffrey W. , Naselsky Warren , Eckert Richard L.
Published: September 2021

Transglutaminase 2 (TG2) is a key epidermal squamous cell carcinoma cancer cell survival protein. However, how TG2 maintains the aggressive cancer phenotype is not well understood. The present studies show that TG2, which is highly expressed in epidermal cancer stem–like cells (ECS cells), maintains hepatocyte growth factor (HGF) signaling to drive an aggressive ECS cell cancer phenotype. Inhibiting TG2 reduces MET tyrosine kinase receptor expression and activity and attenuates the cancer cell phenotype. Moreover, inhibition of TG2 or HGF/MET function reduces downstream MEK1/2 and ERK1/2 activity, and this is associated with reduced cancer cell spheroid formation, invasion, and migration, and reduced stem and EMT marker expression. Treatment of TG2 knockdown cells with HGF partially restores the aggressive cancer phenotype, confirming that MET signaling is downstream of TG2. MET knockout reduces ERK1/2 signaling, doubles the time to initial tumor appearance, and reduces overall tumor growth. These findings suggest that TG2 maintains HGF/MET and MAPK (MEK1/2 and ERK1/2) signaling to drive the aggressive ECS cell cancer phenotype and tumor formation, and that TG2-dependent MET signaling may be a useful anti-cancer target.

Implications:

TG2 is an important epidermal squamous cell carcinoma stem cell survival protein. We show that TG2 activates an HGF/MET, MEK1/2 ERK1/2 signaling cascade that maintains the aggressive cancer phenotype.
Circulating Tumor DNA in Lymphoma: Principles and Future Directions
Authors: Roschewski Mark , Rossi Davide , Kurtz David M. , Alizadeh Ash A. , Wilson Wyndham H.
Published: September 2021

Lymphomas are heterogeneous tumors with striking genetic diversity and variable outcomes even within pathologic diagnoses. Treatment response assessment relies on radiologic and nuclear scans, which cannot detect disease at the molecular level. Molecular tumor analyses require invasive tissue biopsies that cannot accurately capture spatial tumor heterogeneity within each patient. Circulating tumor DNA (ctDNA) is a minimally invasive and highly versatile biomarker that overcomes fundamental limitations of imaging scans and tissue biopsies and may aid clinical decision-making in lymphoma. In this review, we highlight the key established principles regarding ctDNA in lymphoma and emphasize the important research questions and future directions.

Significance:

ctDNA is an emerging biomarker for lymphomas that noninvasively provides genotypic information and can measure the effectiveness of treatment by detecting the presence of minimal residual disease. Key principles have emerged related to ctDNA for lymphoma, but further studies are needed to standardize its use and establish clinical utility.
Lutas por autodefinição de subjetividades negras em contextos organizacionais: racismo, autoimagem e resistências afrodiaspóricas
Authors: Oliveira Luciana de , Santos Ester Antonieta , Carvalho Frederico Mendes de , Oliveira Washington Luís Santos
Published: September 2021

Neste artigo, discutimos algumas tensões entre modulações discursivas antirracistas em contextos organizacionais em face a episódios de racismo e ações individuais de trabalhadores e trabalhadoras para denunciá-los e repará-los judicialmente. Metodologicamente, analisamos sete casos que tiveram visibilidade midiática a partir de busca no acervo da Folha de S.Paulo entre 2000 e 2021, nos quais verificamos operações discursivas das categorias consciência ocidental do negro (racismo) e consciência negra do negro (autodefinição), de acordo com o conceito de razão negra.
Novo padrão brasileiro de rotulagem de alimentos embalados: modelos, discursos e controvérsias
Authors: Teixeira Lucas de Vasconcelos , Hoff Tânia Márcia Cesar
Published: September 2021

O objetivo deste artigo é examinar as disputas sobre o novo padrão de rotulagem nutricional brasileiro. A empiria é composta por entrevistas concedidas por representantes de entidades vinculadas à indústria alimentícia ou sociedade civil. A metodologia é a análise de conteúdo. Os resultados reverberam para além dos rótulos, envolvendo relações de poder, discursos e produção de verdades. A controvérsia entre comida natural e ultraprocessada permeia esses discursos, cada qual buscando legitimar suas próprias verdades.
Precisamos falar de Marx: e isso pode começar pela comunicação organizacional
Authors: Ferreira Dôuglas Aparecido
Published: September 2021

Este artigo é uma provocação teórica que parte da constatação de uma lacuna nos estudos da comunicação organizacional. Para isso, nos fundamentamos na aproximação de Marx com a perspectiva praxiológica de Quéré, entendendo que essa articulação pode trazer contribuições para as investigações das contradições do capitalismo. Como resultado, o artigo apresenta o esboço de um trajeto metodológico para compreender objetos da comunicação organizacional, de modo que se revelem as contradições do capitalismo, contribuindo para a transformação da realidade.