bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of a Ketogenic Diet Combined with Aerobic Exercise on Muscle Fiber Types and Exercise Capacity in Tail-Suspended Mice
Authors: Jun Chen , Wenjiong Li , Liang Yu , Bowei Zhang , Zhili Li , Peng Zou , Bai Ding , Xiaoqian Dai , Qirong Wang
Published: January 2025

Objective: To investigate the effects of an 8-week ketogenic diet combined with aero-bic exercise on muscle fiber composition and exercise capacity in mice subjected to simulated microgravity. Methods: Seven-week-old male C57BL/6J mice were randomly assigned to six groups: normal diet (NC), ketogenic diet (KC), normal diet + tail sus-pension (NH), ketogenic diet + tail suspension (KH), normal diet + tail suspension + exercise (NHE), and ketogenic diet + tail suspension + exercise (KHE). During the final two weeks of the intervention, a tail suspension model was employed to simulate mi-crogravity in the tail suspension groups, while the exercise groups performed moder-ate-intensity aerobic exercise. The exercise protocol involved running at 12 m/min for 60 minutes per day, 6 days per week, over the course of 8 weeks. Weekly measure-ments included body weight, blood ketones, and blood glucose concentrations. Respir-atory metabolic rates were assessed before and after tail suspension. Following the in-tervention, all mice underwent a forced exercise test. Blood was collected via the or-bital sinus immediately after the test, and the bilateral soleus muscles were quickly ex-cised. Biochemical analysis was performed to assess blood markers, and Western blot-ting and RT-PCR were used to examine changes in protein and gene expression in skeletal muscle. Additionally, Oil Red O and PAS staining were utilized to evaluate li-pid deposition and glycogen content in the muscles. Immunofluorescence staining was employed to analyze the distribution of MHC muscle fibers in skeletal muscle. Results: Mice in the tail suspension model exhibited weight loss, muscle atrophy, shifts in muscle fiber type, and decreased endurance. However, the combined intervention of a ketogenic diet and aerobic exercise significantly reduced markers of muscle atrophy, enhanced the expression of proteins and genes related to fat metabolism, increased the proportion of MHC-I muscle fibers in the soleus muscle, and decreased the proportion of MHC-IIb fibers. This combined intervention, which primarily utilizes ketone body metabolism, significantly enhanced fat metabolism, thereby improving exercise capac-ity in the mice. Conclusion: The combined intervention of a ketogenic diet and aerobic exercise effectively mitigated muscle atrophy in mice subjected to simulated micro-gravity, enhanced the expression of fat metabolism-related genes in skeletal muscles, and inhibited the transition from slow-twitch to fast-twitch muscle fibers, ultimately improving the exercise capacity of the mice.
GEF1 Is a Novel Factor Regulating Nickel Ion Metabolism in Saccharomyces cerevisiae
Authors: Li Qianqian , Zong Lixuan , Brake Joseph , Huang Rongqiu , Luo Chaoyang , Bian Jiang , Wu Xiaobin
Published: January 2025

Nickel is a trace element essential for human life. Currently, studies on the metabolism and function of nickel ions mainly focus on prokaryotes, while the role of nickel ions in eukaryotes is still being explored. In this study, we found for the first time that GEF1 which encodes Gef1p, a chloride transport protein located in the Golgi membrane, is involved in nickel ion metabolism in yeast. The GEF1 knockout strain (gef1∆) showed strong resistance to excess nickel ions, and the content of nickel ions in gef1∆ cells was significantly elevated. The results of transcriptomics analysis showed significant upregulation of MMT2 and CUP1 in gef1∆ cells supplemented with nickel. Both MMT2 and CUP1 overexpressed in the gef1∆ strain showed a growth advantage on nickel media. Nickel ion content in the mitochondria of cells overexpressing MMT2 was significantly elevated, and the levels of reactive oxygen species were significantly decreased in strains overexpressing either the MMT2 or CUP1 genes. This study reveals that the GEF1 gene plays an important role in nickel homeostasis, and that upregulation of MMT2 and CUP1 is critical for gef1∆ strains to counteract ROS formation and growth defect by nickel ions.
A Novel Device for Automated Removal of 3D Printed Parts from Build Platforms
Authors: B Sankar , H Kishore Kumaar , Sen Dibakar
Published: January 2025

The removal of 3D-printed parts from build platforms in Stereolithographic (SLA) printing poses significant challenges due to the strong adhesion of parts to the build platform. A device was designed that employs a guided sliding blade mechanism, effectively utilizing the wedge effect for safe and efficient detachment. This method minimizes damage to both the printed parts and the build platform, enhancing the efficiency and safety of the post-printing process. The efficacy of the design was demonstrated with multiple 3D-printed parts of different materials and sizes.
Exploring the Role of pH and Solar Light-Driven Decontamination with Singlet Oxygen in Removing Emerging Pollutants from Agri-Food Effluents: The Case of Acetamiprid
Authors: Fabregat Víctor
Published: January 2025

Previously synthesized and tested water-dispersible photoactive polymeric microparticles have been employed as heterogenous photosensitizers to evaluate their performance in generating singlet oxygen through direct solar irradiation. This study utilizes these photocatalysts for the degradation of Acetamiprid in IWWTP wastewater effluents from an Agri-food industry, exploring, in addition to direct or simulated solar irradiation, the influence of pH on the photooxidation process. Over a thousand Emerging Pollutants, including pesticides like Acetamiprid, have been detected in aquatic environments in recent years, posing challenges due to the limitations of current wastewater treatment technologies. The developed method is particularly effective under basic or slightly basic conditions, aligning with the natural pH of wastewater and addressing a limitation of conventional Acetamiprid degradation methods, which typically require medium acidification to be effective. Polymers P3 and P4 exhibited high photocatalytic activity, achieving over 99% degradation of Acetamiprid through oxidation via singlet oxygen generated by Rose Bengal supported on the polymer matrix, while maintaining catalytic efficiency across multiple cycles The results confirm that Acetamiprid removal from industrial wastewater via direct solar irradiation is feasible, though constrained by the availability of sufficient effective sunlight hours.
Multiple Myeloma Insights from Single-Cell Analysis: Clonal Evolution, the Microenvironment, Therapy Evasion, and Clinical Implications
Authors: Li Sihong , Liu Jiahui , Peyton Madeline , Lazaro Olivia , Huang Xiaoqing , Shi Zanyu , Zhang Zhiqi , Walker Brian , Johnson Travis
Published: January 2025

Multiple myeloma (MM) is a complex and heterogeneous hematologic malignancy characterized by clonal evolution, genetic instability, and interactions with a supportive tumor microenvironment. These factors contribute to treatment resistance, disease progression, and significant variability in clinical outcomes among patients. This review explores the mechanisms underlying MM progression, including the genetic and epigenetic changes that drive clonal evolution, the role of the bone marrow microenvironment in supporting tumor growth and immune evasion, and the impact of genomic instability. We highlight the critical insights gained from single-cell technologies, such as single cell transcriptomics, genomics and multiomics, which have enabled a detailed understanding of MM heterogeneity at the cellular level, facilitating the identification of rare cell populations and mechanisms of drug resistance. Despite the promise of these advanced technologies, challenges remain in their clinical application, including high costs, data complexity, and the need for standardized bioinformatics and ethical considerations. This review emphasizes the importance of continued research and collaboration to address these challenges, ultimately aiming to enhance personalized treatment strategies and improve patient outcomes in MM.
A Review of Detection, Evolution, and Data Reconstruction Strategies for False Data Injection Attacks in Power Cyber-Physical Systems
Authors: Bo Xiaoyong
Published: January 2025

The integration of information and physical systems in modern power grids has heightened vulnerabilities to False Data Injection Attacks (FDIAs), threatening the secure operation of power cyber-physical systems (CPS). This paper reviews FDIA detection, evolution, and data reconstruction strategies, highlighting cross-domain coordination, multi-temporal evolution, and stealth characteristics. Challenges in existing detection methods, including poor interpretability and data imbalance, are discussed, alongside advanced state-aware and action-control data reconstruction techniques. Key issues, such as modeling FDIA evolution and distinguishing malicious data from regular faults, are identified. Future directions to enhance system resilience and detection accuracy are proposed, contributing to the secure operation of power CPS.
An Automated Lint Grading Sample Collection Framework and Cost-Benefit Analysis Proposal for Cotton Gins
Authors: Adeleke Adeyemi
Published: January 2025

As the natural fiber of choice, cotton has a massive global value chain worth around $40 billion. Grown in several countries within the tropical and subtropical regions, it employs about 400 million people, from farms to textile mills. Post harvesting, commercial gins separate seed cotton into seeds and lint, the most economically important cotton product. After ginning the lint and pressing it into bales, samples are drawn manually for classing by regulatory agencies, such as the United States Department of Agriculture (USDA) in the US and the China Inspection and Quarantine (CIQ) in China, which are two leading global cotton-producing countries. Manual sampling depends on increasingly scarce seasonal agricultural workers and is thus suitable for automation as a repetitive process. Therefore, serial robots as automation agents with increasing industrial applications are a good substitute candidate for human lint grading sample collectors at cotton gins. This work proposes a framework for adopting low-cost serial robots for lint sample collection at existing and new cotton gins. In addition to their programmability, high-performance repeatability, and accuracy, the cost-benefit analysis indicated that low-cost robots have a payback time of one to two years despite their intimidating initial capital outlay. Finally, this article recommends that commercial gin operators and designers who want to optimize their gins and hedge against decreasing labor supply and profit margin should adopt the proposed framework.
Economic Competitiveness of SMRs in a Net Zero Policy
Authors: Alonso Gustavo
Published: January 2025

The deployment of large nuclear reactors are intensive capital projects, national governments and a few independent worldwide companies that can afford the financial risk can pursue them. To cope with this financial disadvantage, small modular reactors (SMRs) have become an alternative; they can provide electricity to different needs far below the electricity capacity supplied by a large reactor and fit in new markets. Several of them could fill the capacity of a large reactor. However, SMRs have a higher cost for kW deployed than a Large Reactor because of the economy of scale. At this point, SMR designs backed by a national government will have higher opportunities for success. The present paper analyzes several economic factors under different electricity-selling prices to determine the possible role of SMR as a complement or competitor of Large Reactors. Results show that for low electricity-selling prices SMR is more a complementary infrastructure, but can be a market competitor for higher prices. The study also provides information about the required economic scenario where nuclear reactors, small and large, could be part of the net-zero policy from a financial point of view.
Shifting Outcomes: Superior Functional Recovery in Embolic Stroke of Undetermined Source Compared to Cardioembolic Stroke
Authors: Seetge Jessica , Cséke Balázs , Karádi Zsófia Nozomi , Bosnyák Edit , Szapáry László
Published: January 2025

Background/Objectives: Embolic Stroke of Undetermined Source (ESUS) is a subtype of ischemic stroke characterized by a non-lacunar infarct in the absence of a clearly identifiable embolic source, despite comprehensive diagnostic evaluation. While ESUS patients are typically younger, have fewer cardiovascular comorbidities, and experience milder strokes than those with cardioembolic strokes (CE), their long-term functional recovery remains underexplored. Methods: We retrospectively analyzed data from 317 ischemic stroke patients (n = 37 ESUS, n = 280 CE) admitted to the Department of Neurology, University of Pécs, between February 2023 and September 2024. Functional recovery was assessed using the modified Rankin Scale (mRS), adjusted for baseline differences (adjusted mRS-shift). Independent predictors of mRS-shift were identified using Firth penalized regression and extreme gradient boosting (XGBoost). Results: ESUS patients were significantly younger (53.8 ± 13.5 years vs. 75.1 ± 11.3 years, p <0.001), had lower pre-morbid modified Rankin Scale (pre-mRS) scores (0.22 ± 0.75 vs. 0.81 ± 1.23, p <0.001), were less likely to have hypertension (70.3% vs. 86.1%, p = 0.027), and presented with milder strokes at admission (National Institutes of Health Stroke Scale [NIHSS] score 5.5 ± 3.6 vs. 8.1 ± 6.3, p <0.001) and 72 hours post-stroke (2.8 ± 3.7 vs. 6.5 ± 6.3, p <0.001) compared to CE patients. After adjusting for baseline differences, ESUS patients had significantly better functional recovery (adjusted mRS-shift 1.30 ± 1.71 vs. 2.27 ± 2.17, p <0.001). Conclusions: ESUS patients showed superior functional recovery compared to CE patients, even after adjusting for baseline differences. These findings highlight the need for further research into the pathophysiology and optimal treatment for ESUS.
Assessing the Socio-economic Potential of Cashew Nut Farming in Rangamati, Bangladesh
Authors: Chakma Amit , Chakma Netui , Chakma Omeek , Talukder Eco , Rabbany Md. Yeamin , Jamal Samrina , AL Mahbub Hossain , Ahmed Rashed
Published: January 2025

The socioeconomic and environmental potential of cashew nut production in Bangladesh's Ranganati Hill District is examined in this study while emphasizing the crop's potential as a cash crop for rural development. With yields of 1.4 to 1.8 tons per hectare and net returns exceeding those of conventional crops, cashew farming—which was first promoted by the Department of Agricultural Extension and the Chittagong Hill Tracts Development Board—has proven very profitable. Despite advantageous agro-climatic conditions, the industry nevertheless confronts obstacles, including weak marketing infrastructure, insufficient financial facilities, and restricted availability of high-quality planting supplies. Sixty farmers participated in the research, which was carried out in eight Ranganati upazilas. It used primary and secondary data to examine the variables that affect cashew production, such as land types, seedling sources, cultivation expenses, and economic profitability. According to the findings, steep hills were the favoured land type, and 63% of farmers switched to cashew growing because it was profitable. Most farmers paid between 11,000 and 15,000 Taka a year for cultivation and obtained seedlings from the Upazila Agriculture Office (UAO). With domestic pricing between 500 and 600 BDT per kilogram and production costs between 300 and 350 BDT, cashew cultivation exhibits strong economic viability, resulting in a 95–100% profit margin. However, the sector's expansion is hampered by a lack of high-quality processing facilities and training. The research comes to the conclusion that cashew farming may greatly boost rural employment, poverty alleviation, and GDP development in Bangladesh with the right governmental support, infrastructural investment, and capacity building.
Propensity Score Matching Use in Nursing: A Synthetic Near Empty Review and Search for New Opportunities
Authors: Blažun Helena , Kokol Peter , Završnik Jernej
Published: January 2025

Background: The frequency of proximity score matching (PSM) use in research is exponentially increasing; however, its use in nursing has not yet been explored and is possibly underused. Methods: Synthetic analyses were used first to identify the content of the current nursing PSM studies; second, the content of nursing observational, retrospective, or other quasi-experimental studies; and finally, based on the above analyses, exploring new possibilities for further use of PMS in nursing. Findings: The use of PSM in nursing is very sparse, but the number and content of observational, retrospective, and similar nursing research is increasing and becoming more extensive. Ten prolific themes in nursing observational studies were identified. Based on these studies, several influential studies in which PSM has already been successfully used in comparable healthcare topics have been selected as opportunities for extended PSM use in nursing. Conclusions: Extended use of PSM in nursing research might make nursing research more consistent, relevant, internally and externally valid, and consequently more useful in clinical practice and research.
The Expression of F2RL1, P2RX2, P2RX3 and P2RY2 in the Esophagus of Patients with Gastroesophageal Reflux Disease and Their Relationship to Reflux Symptoms – a Pilot Study
Authors: Mokrowiecka Anna , Bartoszek Adrian , Fabisiak Adam , Wróbel Agata , Fichna Jakub , Wierzchniewska-Ławska Agnieszka , Jacenik Damian , Małecka-Wojciesko Ewa
Published: January 2025

Background: Current treatment of gastroesophageal reflux disease (GERD) is focused on decreasing the gastric acid secretion. However, there is still a group of patients not responding to conventional therapy. Proteinase-activated receptors and purinergic receptors have been involved in inflammation, visceral hyperalgesia, and esophageal hypersensitivity. The aim of this study was to evaluate the esophageal expression of PAR2 (F2RL1) and P2RX2, P2RX3 and P2RY2 in GERD patients. Methods: The expression of studied receptors was quantified using real-time PCR in esophageal biopsies in patients with GERD and healthy controls. Correlation between dilated intracellular spaces (DIS) score and patients’ quality of life was investigated. Results: PAR2 receptor expression was higher in ERD compared to NERD and controls (326.10±112.30 vs 266.90±84.76 vs 77.60±28.50; NS).P2X2 exhibited the highest expression in NERD compared to ERD and controls (302.20±82.94 vs 40.18±17.78 vs 26.81±10.27), similarly to P2Y2 which expression was higher in NERD than in ERD and controls (7321.00±1651.00 vs 5306.0±1738.00 vs 3476.00±508.0). Conclusions: We found that the expression of F2RL1, P2RX2 and P2RY2 is positively correlated to DIS score in GERD patients. Higher PAR2, P2X2 and P2Y2 expression could mediate sensitization of esophagus and may be associated with higher intensity of symptoms perceived by NERD patients.
Pre- and Post-Operative Exercise Protocol for Infants with Tongue-Tie: Clinical and Caregiver Perspectives
Authors: Cook Thea Louise , Nolan Elliana , Tseng Raymond J , Smart Sharon
Published: January 2025

Purpose: Ankyloglossia or tongue-tie (TT) occurs when the lingual frenulum is visually altered and accompanied by restricted tongue mobility causing feeding and other difficulties with infants. Pre- and post-operative care is reported to be effective to prevent tissue reattachment and ensure feeding success. The purpose of this study was to obtain feedback and insights from caregivers and health professionals for an evidence-based pre- and post-operative exercise protocol for breastfeeding infants undergoing surgical management for TT.
Methods: A qualitative approach was used to evaluate an evidence-based pre- and post-operative exercise protocol for infants with TT, through virtual semi-structured interviews with healthcare professionals and caregivers of children with TT. Five caregivers and eight current practicing clinicians were interviewed to obtain feedback on the protocol. Results were analysed using thematic analysis.
Results: Four themes were generated from participants: 1) Parental confidence and competence; 2) The need for individualised and adaptable instruction; 3) Supporting the caregiver and infant equally; and 4) Regular and periodic support and adjustment to protocol. Conclusion: Key findings from the qualitative interviews included: fostering parental confidence and education; adaptability and flexibility in care; and clinician reassurance throughout the process. Participants suggested these factors would contribute to greater adherence to care protocols and improved outcomes for both infants and their families. This research emphasizes the importance of providing care that extends beyond exercise logistics, and instead, recommends a mindful, family-centred approach that empowers and motivates caregivers throughout the process.
Outpatient Management of a Pediatric Morel-Lavallée Lesion
Authors: Rapole Sanika , Gandhi Tejas , Sodhai Vivek , Patwardhan Sandeep , Sancheti Parag
Published: January 2025

Case:

Pediatric Morel-Lavallée lesions are infrequent and may present in atypical locations. A 3-year-old boy presented with a nontender, mobile, cystic swelling on the medial aspect of his left distal thigh, 2 weeks after a road traffic accident. The diagnosis was confirmed using 3D ultrasonography. The lesion was treated with percutaneous aspiration and drainage without anesthesia, followed by an elastic compression bandage on an outpatient basis. Subsequent follow-up showed no recurrence, and the patient achieved full functional status within 4 weeks and was asymptomatic at 1-year follow-up.

Conclusion:

Percutaneous aspiration and drainage without anesthesia is a safe and effective outpatient treatment for children without fractures.
Closed Management of a Bent Tibial Nail: Can Revision Be Avoided?
Authors: Mousley Johanna J. , Kjar Richard , Reidy Michael , Lambers Anton
Published: January 2025

Case:

A 49-year-old gentleman sustained a closed, right tibia peri-implant fracture with a bent intramedullary nail. This resulted in a 17° valgus and 5° recurvatum deformity with fracture at the distal third of the tibial shaft. The patient underwent closed manipulation with an F-Tool and was reviewed by our unit over the following year.

Conclusion:

This is the first case report of closed manipulation of a tibial fracture over a bent implant. This approach was successful in correcting deformity to within acceptable limits, achieved radiological union, and was associated with excellent patient-reported outcomes at all points of follow-up.
Sternoclavicular Joint Reconstruction Using a Hamstring and Cadaveric Fibular Cortical Allograft
Authors: Gaetano Andrew , Boubekri Amir , Chen Andrew , Garbis Nickolas , Salazar Dane
Published: January 2025

Case:

A 49-year-old woman with sternoclavicular insufficiency following medial clavicle resection underwent sternoclavicular joint reconstruction using a hamstring allograft and a cadaveric fibular cortical allograft. After 4 months of follow-up, the patient was pain-free, with radiographic evidence of graft incorporation by 8 months.

Conclusion:

Medial clavicle resection is a rare procedure with broad indications. The necessity and optimal technique for subsequent sternoclavicular reconstruction remain debated. We demonstrate a figure-of-eight reconstructive technique that may provide acceptable clinical results when addressing large medial clavicle defects.

Level of Evidence:

IV.
Triple Pelvic Osteotomy Provides Joint Stability and Acetabular Bone Stock Following Hip Hemiarthroplasty for Ewing Sarcoma
Authors: Breulmann Franziska Lioba , Andronic Octavian , Müller Daniel , Canonica Sandro , Nieuwland Arend , Dreher Thomas
Published: January 2025

Case:

Triple pelvic osteotomy (TPO) is used to treat developmental dysplasia of the hip in a pediatric population. This case report highlights a new indication for this procedure. Acetabular coverage was restored in a 9-year-old patient who experienced instability following hip hemiarthroplasty and proximal femur composite allograft implantation for the treatment of Ewing sarcoma.

Conclusion:

TPO can be used to treat instability following prosthetic hip replacement in pediatric patients with open triradiate cartilage. It restores the acetabular bone stock and should facilitate future acetabular component implantation or revisions.
Detection of Multiple Tibial Malalignment-Induced Early Polyethylene Breakage Using Single Plane Fluoroscopy
Authors: Sugimoto Atsushi , Ishibashi Teruya , Yamazaki Takaharu , Tamaki Masashi , Okada Seiji , Tomita Tetsuya
Published: January 2025

Case:

A 75-year-old woman underwent cruciate retaining total knee arthroplasty (TKA) for osteonecrosis of the knee, converted from unicompartmental arthroplasty due to an intraoperative medial tibial plateau fracture. Four years later, she experienced persistent knee pain. Computed tomography revealed tibial malalignments in 2 planes. In vivo kinematic analysis using single-plane fluoroscopy, which can visualize the femorotibial contact, indicated varus thrust with lateral subluxation of the tibial component and the femoral component recessing into the polyethylene insert. Revision TKA affirmed the polyethylene insert breakage.

Conclusion:

Malalignment might have caused mechanical failure, and in vivo kinematic analysis was useful to visualize abnormal kinematics in TKA.
VITALITAS BAHASA MADURA : TINJAUAN AWAL DALAM PEMERTAHANAN BAHASA IBU PENDUDUK MADURA DI SURABAYA
Authors: Rachma Evi Pebri Ila , Mohammad Halili
Published: January 2025

Surabaya sebagai kota multietnis dipilih sebagai daerah penelitian. Bahasa Jawa sebagai bahasa yang banyak digunakan dan Madura sebagai bahasa minoritas di Surabaya. Bahasa Madura merupakan bagian dari multiligualisme yang ada di Surabaya. Penelitian ini berfokus pada domain yang mempengaruhi komunikasi dan vitalitas bahasa Madura di Surabaya. Penelitian ini merupakan penelitian deskriptif kuantitatif dengan menggunakan instrumen kuesioner. Hasil penelitian ini menunjukkan bahwa vitalitas bahasa Madura tidak dalam skala aman, melainkan dalam skala rentan. Penggunaan bahasa Madura rendah pada ranah seperti mobilitas penduduk, transmisi bahasa antar generasi, penggunaan dalam komunikasi dengan pemerintahan, penggunaan di ranah pendidikan, kedwibahasaan, agama dan pendokumentasian bahasa.
Kata Kunci : vatalitas bahasa, bahasa Madura, pemertahanan bahasa .
REKONSTRUKSI JARINGAN KOMPUTER DENGAN METODE TOP-DOWN (STUDI KASUS SMKN 3 BANGKALAN)
Authors: Tahir Muhlis , Aini Nuru , Cahyani Laili , Yuni Wijaya Etistika , Afif Effindi Muhamad , Dellia Prita
Published: January 2025

Jaringan komputer terdiri dari dua atau lebih perangkat komputasi yang saling berhubungan atau terhubung dan digunakan untuk sumber data yang berbeda.. SMK Negeri 3 Bangkalan  selama ini tekah memiliki rangkaian jaringan LAN  yang sudah dan telah menerapkan sistem teknologi komputer pada beberapa aktivitas di  lingkungan sekolah, sehingga  kondisi jaringan komputer yang ada di sekolah tersebut dalam kondisi baik, cepat dan aman namun seiring berjalannya waktu rangkaian jaringan LAN yang terbentuk dengan mulai mengalami gangguan pada kabel koneksi jaringan, SMKN 3 Bangkalan  yang mungkin mengalami masalah pada kinerja jaringan karena komputer. Metode top-down banyak digunakan untuk pengembangan jaringan, dan metode top-down itu sendiri adalah metode untuk membangun jaringan area lokal di mana setiap unit dibangun pada waktu yang sama. Hasil analisis perbandingan PING pada IP awal dengan IP tujuan diketahui dalam kondisi jaringan existing mendapatkan nilai waktu PING 1072 ms dan average 52. 48 ms untuk TTL yang didapatkan dengan nilai waktu 28421 ms dan average 1561.86 ms, sedangkan pada kondisi jaringan yang diusulkan mendapatkan nilai waktu PING 59 ms dan average 2.7776 ms untuk TTL yang didapatkan dengan nilai waktu 27741 ms dan average 1566.67 ms, dapat disimpulkan pada kondisi jaringan yang di usulkan untuk nilai  waktu PING  lebih baik dari kondisi existing. Dengan menggunakan metode ini, diharapkan dapat membuat jaringan baru dengan fungsionalitas yang lebih baik.Kata kunci: Jaringan Komputer, SMKN 3 Bangkalan , Top Down
IMPLEMENTASI JSON PARSING UNTUK PERTUKARAN DATA PADA APLIKASI VPN CLIENT BERBASIS MOBILE
Authors: Guna Nandana Surya , Rahmatulloh Alam , Rachman Andi Nur
Published: January 2025

Meningkatnya permintaan akan transmisi data yang aman pada perangkat mobile, penting untuk mengembangkan metode yang efisien untuk pertukaran data sambil menjaga integritas dan kerahasiaan informasi. Penelitian ini bertujuan untuk mengatasi masalah implementasi JSON Parsing dalam pertukaran data pada aplikasi klien VPN berbasis mobile menggunakan layanan web. Salah satu tantangan yang dihadapi selama proses pengembangan adalah pembatasan alamat IP web service. Untuk mengatasi pembatasan ini, pengguna harus menghubungkan perangkat ke jaringan VPN, yang memungkinkan untuk mengubah kata sandi dan membuat catatan kehadiran dengan aman. Penelitian ini juga mencakup pengujian penerimaan untuk mengevaluasi kinerja aplikasi. Hasil pengujian menunjukkan hasil yang memuaskan, menandakan keberhasilan implementasi JSON Parsing dan fungsi layanan web. Selain itu, pengujian kinerja jaringan mengungkapkan bahwa waktu respons dipengaruhi oleh metode dan lokasi jaringan yang dipilih. Waktu respons untuk pengambilan data kehadiran pada jaringan default adalah 1187 ms, namun respons untuk pengiriman data kehadiran dan pengubahan kata sandi adalah 403 karena web service membatasi akses dengan alamat IP. Sementara itu, jaringan SgVPN untuk permintaan pengubahan password memiliki waktu respons sekitar 1088 ms, pengambilan data kehadiran sekitar 1727 ms, dan pengiriman data kehadirans sekitar 955 ms. Sedangkan pada jaringan DeVPN, permintaan pengubahan password memiliki waktu respons sekitar 1264 ms, pengambilan data kehadiran sekitar 1793 ms, dan pengiriman data kehadirans sekitar 1351 ms. Temuan ini menekankan pentingnya mempertimbangkan lokasi jaringan dalam upaya mengoptimalkan waktu respons aplikasi.Kata kunci: Aplikasi Klien VPN, Jaringan VPN, JSON Parsing, Layanan Web, Waktu Respons
KLASIFIKASI DIAGNOSIS DIABETES MELITUS MENGGUNAKAN METODE NAÏVE BAYES DENGAN SELEKSI FITUR BACKWARD ELIMINATION
Authors: Nugroho Hendro , Yuliastuti Gusti Eka , Pradana Andrean Firman
Published: January 2025

Diabetes mellitus is a dangerous disease caused by high sugar levels (hyperglycemia). Hyperglycemia can cause sufferers to experience chronic disease, damage to organs in the body. Diabetes mellitus is a dangerous disease, so it is very interesting to classify diabetes mellitus using the Naïve Bayes method with Backward Elimination (BE) feature selection. The Diabetes mellitus dataset used in the research consisted of 101 data with 5 attributes consisting of age, Current Blood Sugar (GDS), 2 hours after eating/Post Pradial (PP), Fasting Blood Sugar (GPD) levels, and Low Density Lipoprotein (LDL) . To get classification results, there are several steps taken, namely data input, BE feature selection, 8-Fold Cross Validation, Naïve Bayes and results testing. From the classification results, testing was carried out using the accuracy, precision and recall calculation method. To find out the results of classification performance, four test scenarios were carried out, namely the first scenario, Naïve Bayes combined with BE and 8-Fold Cross Validation, accuracy of 77%, second scenario, Naïve Bayes combined with 8-Fold Cross Validation, accuracy of 78.1%, third scenario, Naïve Bayes combined with BE accuracy is 86% and the fourth scenario of Naïve Bayes classification accuracy is 90%, so the accuracy of Naïve Bayes classification with BE feature selection is better.Keywords: Diabetes melitus, Naïve bayes, Backward Elimination. 8-Flod Cross Validation.
RANCANG BANGUN SISTEM PAKAR DIAGNOSA HAMA DAN PENYAKIT TANAMAN BAWANG MERAH DAN CABAI MENGUNAKAN METODE FORWARD CHAINING
Authors: Fatah Doni Abdul , Rifqi Khoirur , Sawaki Sawaki , Irhamni Firli
Published: January 2025

Sistem pakar merupakan suatu program komputer cerdas yang menggunakan pengetahuan dan prosedur inferensi untuk memecahkan masalah-masalah yang cukup kompleks, sehingga membutuhkan keahlian dan pengalaman seorang pakar untuk menyelesaikannya. Dalam bidang pertanian, sistem pakar dapat dimanfaatkan untuk membantu petani dan penyuluh pertanian dalam mengidentifikasi dan mengatasi berbagai masalah terkait hama dan penyakit pada tanaman. Penelitian ini bertujuan untuk merancang dan mengembangkan sebuah sistem pakar untuk mendiagnosis hama dan penyakit pada tanaman bawang merah dan cabai menggunakan metode forward chaining. Sistem pakar ini dirancang untuk menjadi alat bantu yang dapat membantu petani dan penyuluh pertanian dalam mengidentifikasi jenis hama dan penyakit yang menyerang tanaman, serta memberikan solusi penanganannya secara cepat dan akurat. Sistem pakar yang dihasilkan dalam penelitian ini merupakan sistem berbasis aturan (rule-based) yang mampu mengidentifikasi jenis hama dan penyakit berdasarkan gejala-gejala yang diamati, serta memberikan rekomendasi penanganannya. Hasil pengujian menunjukkan bahwa sistem pakar ini memiliki tingkat akurasi sebesar 90% dalam mendiagnosis hama dan penyakit pada tanaman bawang merah dan cabai. Dengan demikian, sistem pakar dapat menjadi alat bantu yang efektif bagi petani dan penyuluh pertanian dalam upaya meningkatkan produktivitas tanaman bawang merah dan cabai.Kata kunci: bawang merah, cabai, forward chaining, hama, penyakit, sistem pakar
SELEKSI FITUR ALGORITMA GENETIKA DALAM KLASIFIKASI DATA REKAM MEDIS PCOS MENGGUNAKAN SVM
Authors: Novianti Fahriza , Ulinnuha Nurissaidah
Published: January 2025

A hormonal imbalance causes a woman with polycystic ovarian syndrome (PCOS) to have an ovum or egg that does not mature normally. It usually occurs during the reproductive period, but is often difficult to detect due to lack of awareness. Therefore, it is important to detect this condition early so that proper treatment or prevention can be done. One way to diagnose PCOS is through the use of medical data. In this study, 40 variables were used, including hormonal data, ultrasound results, and other medical information. The method used was Support Vector Machine (SVM), which is able to handle non-linear data with a kernel. To improve accuracy, features were selected using a genetic algorithm, which resulted in 19 significant variables. By applying the selected variables as input, the classification produced the best model with 94.26% accuracy, 87.57% sensitivity, and 97.52% specificity. Without the feature selection process, SVM classification only has an accuracy of 82.46%, sensitivity of 60.91%, and specificity of 97.25%. From the findings of this research, it can be seen that the genetic algorithm feature selection method can improve SVM classification performance. Keywords: Genetic Algorithm, Classification, PCOS, Feature Selection, SVM.
PREDIKSI ANEMIA DARI PIXEL GAMBAR DAN LEVEL HEMOGLOBIN MENGGUNAKAN RANDOM FOREST CLASSIFIER
Authors: Azis Huzain , Rismayanti Nurul
Published: January 2025

Anaemia is a widespread blood disorder characterized by a deficiency of red blood cells or hemoglobin, which can lead to severe health complications if not diagnosed and treated promptly. This research aims to develop a machine learning model to predict anaemia based on hemoglobin levels and image pixel distributions, leveraging a dataset from Kaggle. The dataset includes features such as percentages of red, green, and blue pixels in images and hemoglobin levels. We applied a Random Forest Classifier, a robust machine learning algorithm, and evaluated its performance using 5-fold cross-validation. The data pre-processing involved removing irrelevant columns, encoding categorical variables, and scaling numerical features. The model achieved a mean accuracy of 97.05%, precision of 97.02%, recall of 97.05%, and F1-score of 96.88%, indicating its high reliability in predicting anaemia. Visualizations such as Correlation Heatmaps, 3D PCA, Parallel Coordinates Plots, 3D t-SNE, and Violin Plots were used to understand feature relationships and distributions. These results underscore the potential of machine learning in providing a non-invasive, cost-effective diagnostic tool for anaemia, especially in resource-limited settings. Future research should address dataset imbalance and potential biases, explore additional features, and test other machine learning models to further enhance the predictive accuracy. This study contributes to the field of medical diagnostics by demonstrating the efficacy of integrating hemoglobin levels and image data for anaemia prediction, paving the way for improved early detection and treatment strategies.Keywords: Anaemia, Hemoglobin, Machine Learning, Random Forest.
Purification of Sufism According to Hamka
Authors: Kaplan Muhammed Nur , Zarkasyi Arif Afandi
Published: January 2025

This research investigates Hamka's concept of Modern Sufism as a significant effort to purify and reform traditional Sufism. The study begins by exploring the historical context of Sufism in Indonesia, where it played a pivotal role in the dissemination of Islam but was later influenced by mystical, materialistic, and hedonistic elements. These influences often deviated from the foundational principles of Islam, necessitating a return to its purest form. The study adopts a descriptive and inductive research design, analyzing Hamka's seminal works. The research focuses on Hamka's critique of practices like saint veneration, excessive grave visitation, and misinterpretations of concepts like waḥdah al-wujūd. Hamka's approach emphasizes tawḥīd (the Oneness of God) as a cornerstone of Sufi practice, advocating for a direct and immanent relationship with Allah without intermediaries. The findings reveal that Hamka redefined wealth and poverty in Sufism. Wealth, according to Hamka, is not inherently negative but should be seen as a trust from Allah, to be used for good deeds and social welfare. True poverty, on the other hand, lies in detachment from material possessions, even amidst abundance, reflecting the principle of zuhd (asceticism). Furthermore, Hamka's Modern Sufism rejects hedonistic tendencies by promoting self-control and prioritizing social engagement as essential aspects of a successful Sufi life. The study concludes that Hamka’s Modern Sufism bridges spirituality with societal needs, offering a dynamic and pragmatic framework for addressing the spiritual crises of modern society. His approach not only restores Sufism to its monotheistic roots but also ensures its relevance in contemporary contexts, balancing worldly and spiritual aspirations.
Gestión estratégica y marketing para la exportación en los pequeños productores de palta hass, distrito de Ocobamba (Apurímac – Perú), 2022
Authors:   , Junco Rivera Jose Alberto
Published: January 2025

Para lograr el éxito empresarial, es fundamental conocer los aspectos y procesos clave para alcanzar los objetivos empresariales. Este trabajo se enfoca en la interrelación de gestión estratégica con el marketing para exportación sostenible en las asociaciones de microempresarios productores de palta Hass del distrito de Ocobamba Apurímac, Perú. Metodología basado en un enfoque cuantitativo, empleando un diseño transversal no experimental, se llevó a cabo la selección de una muestra no probabilística por conveniencia de 4 asociaciones, que incluían a 37 microempresarios productores de palta que cumplían con los criterios de inclusión, la encuesta se aplicó a los representantes de estas microempresas mediante un cuestionario de 25 preguntas con escala de likert, para la contratación de la hipótesis se utilizó el valor de asociación de Spearman, para el análisis de la información se utilizó el software SPSS Statistics 26. Los resultados mostraron una asociación positiva moderada entre gestión estratégica y marketing para exportación, con una Rho de Spearman 0.604 con nivel alfa de 0,002, inferior al umbral 0,05. Conclusión, esta investigación determinó la presencia de una asociación de variables gestión estratégica y marketing para exportación en los microempresarios productores de palta Hass. En ese sentido, las microempresas necesitan mejorar y priorizar las tecnologías de producción y comercialización, además de conocimientos y habilidades administrativas en gestión estratégica y marketing para la exportación así para lograr un desarrollo empresarial competitivo y sostenible.
Hábitos de estudio y rendimiento académico de estudiantes de Patología Veterinaria en modalidad remota en línea de una universidad privada de Lima
Authors:   , Salas Castillo Gaby Beatrice
Published: January 2025

La pandemia de la COVID-19 desencadenó que la mayoría de universidades opten por las clases a distancia durante los años 2020 y 2021. Los universitarios quedaron susceptibles a distracciones, poniendo en riesgo el desarrollo de sus hábitos de estudio y su rendimiento académico. El objetivo fue determinar la relación entre los hábitos de estudio y el rendimiento académico de los estudiantes de Patología Veterinaria en modalidad remota en línea de la carrera de Medicina Veterinaria y Zootecnia de una universidad privada de Lima, Perú. Se le envió una encuesta virtual conteniendo los inventarios de Escalante y de Wrenn a 199 estudiantes que llevaron el curso en dicha modalidad durante los semestres 2020-1 al 2021-2. Se analizaron las frecuencias relativas, se usó la prueba de Chi cuadrado para establecer la relación entre hábitos de estudio y rendimiento académico, y se calculó el coeficiente de correlación de Spearman. Se obtuvieron buenos y muy buenos hábitos de estudio, existiendo una correlación positiva leve con el rendimiento académico (rho = 0.168; p = 0.018), pero en su gran mayoría una mala actitud frente al estudio. Este trabajo permite tomar medidas preventivas y correctivas en contextos virtuales, basadas en la mejora de los hábitos de estudio.
Promoting EFL Learners’ Listening Comprehension through Digital Sory-Telling
Authors: Wati Laila , Hamburabbi Muhammad , Wathani Hamzani , Nazri M. Adib , Maysuroh Siti
Published: January 2025

This research is aimed at finding out the effectiveness of digital story-telling in teaching listening at the second semester of Hamzanwadi University. This research is a quantitative research employing pre-exprimental design using one group pre-test and post-test. The sample of this study was 20 students of the second semester class 2d. The data were collected from students pre-test and post-test. The tests were multiple choice. The data were analyzed by using SPSS 22 for Windows. After submitting the data to a paired sample t-test, it was found that there was a significant difference in the mean score in the pre-test and the post-test which was t(df=17)=-30.000 at p=0.000. This means that the hypothesis proposed was proven to be accepted. Besides, the students could more easily grasp meaning especially when the story-telling was presented by video and some keywords related to the material. The activities were also more varied because the students worked more in groups. In short, digital story-telling was significantly effective in teaching listening at the second semester of the English Language Educatioan Study Program in Hamzanwadi University. Thus, it is recomended that English lecturers and teachers use this media in teaching listening.
Transient, Turbulent Hall Currents in the Sunlit Terrestrial Ionosphere
Authors: Ivarsen Magnus , Huyghebaert Devin , Jin Yaqi , Miyashita Yukinaga , St.-Maurice Jean-Pierre , Hussey Glenn , Dan Billett , Kasahara Satoshi , Song Kaili , Jayachandran P , Yokota Shoichiro , Miyoshi Yoshizumi , Kasahara Yoshiya , Shinohara Iku , Matsuoka Ayako
Published: January 2025

At night in Earth's polar regions, energetic aurorae frequently penetrate into the atmosphere, driving turbulent electrojet currents in the bottomside ionosphere. During the day, however, Earth's plasma environment become highly conductive, caused by the constant extreme ultraviolet radiation emitted from the Sun. The high-conductivityplasma in the dayside ionosphere can effectively short out plasma turbulence around aurorae, and so electrojet turbulence is rare in the dayside high-latitude ionosphere. In this report, we show observations to the contrary. During the onset of the 23 April 2023 geomagnetic storm, we observe prolific small-scale plasma turbulence in the dayside E-region on closed magnetic field-lines just equatorward of the cusp. Using data from two orbiting satellites, we infer the location of the cusp and the widespread presence of diffuse aurorae, through observations of particle precipitation and wave-particle interactions near the magnetospheric equator. The diffuse aurorae pass electric fields and produce unstable gradients in the plasma density. The number and intensity of the falling charges overwhelm the capacity of the lower ionosphere to neutralize the charges, spurring the growth of turbulent electrojets. We thereby establish correlation and causality between observations of chorus wave activity near the magnetospheric equator and observations of turbulent electrojets in the ionosphere on closed magnetic field-lines. We discuss the implications that this discovery bears for the electrodynamics of the dayside ionosphere.
Understanding hospital activity and outcomes for people with multimorbidity using electronic health records
Authors: Anand Atul , Georgiev Konstantin , McPeake Joanne , Shenkin Susan , Fleuriot Jacques , Lone Nazir , Guthrie Bruce , Jacko Julie
Published: January 2025

Background
As the prevalence of multimorbidity grows, provision of effective healthcare is more challenging. Both multimorbidity and complexity in delivery of healthcare may be associated with worse outcomes.
Methods
We studied consecutive, unique emergency non-surgical hospitalisations for patients over 50 years old to three hospitals in Scotland, UK between 2016 and 2024 using linked primary care and hospital records to define multimorbidity (2 + long-term conditions), and timestamped hospital electronic health record (EHR) contacts with care providers to study patterns and intensity of inpatient care. The primary outcome was emergency hospital readmission within 30 days of discharge, analysed using multivariable logistic regression.
Results
Across 98,242 consecutive admissions, 84% of the study population had multimorbidity, 50% had 4 + long-term conditions, and 37% had both physical and mental health conditions. Both higher condition count and total number of care provider contacts were independently associated with the primary outcome in fully adjusted models (adjusted odds ratio [aOR] 1.61, 95% CI 1.51 to 1.72 for 4 + conditions compared to no multimorbidity, p < 0.001; aOR 1.10, 95% CI 1.03 to 1.17 for > 12 care provider contacts compared to 1–4, p = 0.01). While multimorbidity was associated with longer hospital stays with more contacts, the distribution of contacts and rehabilitation activity did not differ by multimorbidity or emergency readmission status.
Conclusions
Higher count multimorbidity was associated with an increased risk of readmission, but we observed uniformity in care despite differential outcomes across multimorbidity groups. This may suggest that EHR data-driven approaches could inform person-centred care and improve hospital resource allocation.