bluuebunny/crossref_metadata_2025 huggingface dataset:
Historiografia da arquitetura moderna nos limites
Authors: Dias Rebeca , Chaves Celma
Published: December 2023

O Edifício Banna (Déc. 1960), projeto do engenheiro-arquiteto Alcyr Meira, destaca-se no cenário construtivo de Belém (PA) por congregar atributos como nove apartamentos por andar, térreo comercial, geometrias racionalizadas e soluções típicas da Arquitetura Moderna. Destaca-se também por ser um “Objeto-Limite”, que transita entre distintas definições em relação às suas características socioeconômicas, locacionais, temporais, dentre outras. Propôs-se, então, uma investigação historiográfica do Ed. Banna consoante a estas limiaridades, particularidades e condicionantes. A primeira parte dessa investigação trata de buscar os contextos, as intenções e os pressupostos subjacentes à concepção eprodução do Ed. Banna (enfoque: eventos estruturantes que circunscreveram a consolidação deste edifício). Baseada no recorte temporal que abarca a maioria da produção arquitetônica moderna em Belém (1940-1980), a segunda parte da investigação levanta discussões sobre periodização. Para tanto, recorreu-se à estratégia combinada, metodologia que associa pesquisa qualitativa (levantamentobibliográfico sobre cultura arquitetônica e historiografia da Arquitetura Moderna na Amazônia) e pesquisa histórica. Essa leitura múltipla de um mesmo objeto arquitetônico contribui para dar relevo ao Ed. Banna e, assim, evidenciar as múltiplas significações da trama historiográfica da Arquitetura Moderna em cidades amazônicas.
Revisitando modelos de planejamento de espaços livres
Authors: Meneguetti Karin Schwabe , Oliveira Fabiano Lemes de
Published: December 2023

Desde o século XIX, os projetos das cidades procuram estabelecer espaços livres para o convívio social, em consonância com os modelos de planejamento. Sabe-se que há relação entre os espaços livres e verdes, a conectividade desses e a quantidade e qualidade de espécies que os habitam. As pesquisas se debruçam agora em entender como os espaços edificados podem ser acomodados com menor interferência nos fluxos de fauna e flora. Este artigo de revisão da literatura levanta como a geometria dos sistemas de espaços livres oferece potencialidades ou restrições às funções sociais e ecológicas por meio de casos em que esses modelos foram aplicados. O artigo apresenta inicialmente uma análise conceitual dos modelos de planejamento de cunhas verdes, cinturões verdes e greenways examinando os conceitos fundamentais de infraestrutura verde e destacando as conexões entre as formas espaciais e as funções derivadas dessas formas. Apresenta, então, exemplos desses modelos aplicados a cidades reais, em duas escalas: urbana e regional. Os resultados demonstraram que os três modelos estudados nas cidades são infraestruturas verdes conectadas, mas que se comportam diferentemente principalmente quanto à conexão de áreasflorestadas e à proximidade e distribuição dos espaços verdes pela cidade. A crítica apresentada indica que as formas realmente importam, como potenciais que são, para que demais ações sobre os espaços livres possam garantir suas funções ecológicas ou sociais. Os exemplos podem ajudar nas decisões de planejamento e projeto das cidades e suas expansões, e contribuir na busca por formas espaciais mais responsivas aos desafios crescentes da sustentabilidade.
Os aspectos humanos da favela carioca
Authors: Cestaro Lucas
Published: December 2023

A década de 1950, no Brasil, foi marcada pela euforia desenvolvimentista e personificada pela arquitetura com a construção de Brasília. Em paralelo à esta euforia, no Rio de Janeiro, então capital federal, o número de moradores em favelas crescia, e as mazelas sociais afloravam como um problema a ser entendido e remediado. Esta preocupação abriu espaço para a realização de pesquisas sobre as condições de vida desta população, e possibilitou a atuação de órgãos de assistência técnica recém-criados dentro do quadro de institucionalização do urbanismo no Brasil. O artigo analisa o relatório Aspectos Humanos da Favela Carioca, elaborado pela Sociedade para Análises Gráficas e Mecanográficas Aplicadas aos Complexos Sociais, publicado em 1960 pelo Jornal O Estado de São Paulo. A partir da pesquisa documental, que analisou o relatório mencionado, o artigo explora as principais constatações apontadas pela equipe de pesquisadores quanto à vida nas favelas do Rio de Janeiro. Além disso, o trabalho demonstra a contribuição deste relatório na inserção do reconhecimento da favela como forma de moradia popular, ao mesmo tempo em que tenta minimizar os preconceitos que havia sobre estes territórios populares.
Democracia
Authors: Gibotti Enrico Lentini
Published: December 2023

A democracia é vista predominantemente como sendo a forma de governo mais adequada para um Estado. Entretanto, a quase-unanimidade desta afirmação ofusca os problemas atrelados à democracia, em especial, as diferentes características entre governos categorizados como sendo democráticos, mas que, essencialmente, são diferentes entre si. Há, portanto, um conclave estabelecido no tocante a definição e os elementos constitutivos dessa forma de governo. Este entrave, posicionado em nível teórico, mas com repercussões práticas, é comumente abordado identificando “democracia” como um termo essencialmente contestado e, portanto, possibilitando a sua conformação em uma série de molduras. O ensaio se vale de revisão bibliográfica no tema para discutir sobre a contestabilidade do termo “democracia”, em específico, como a literatura acadêmica entende que existem tipos e subtipos do gênero “democracia”, mas que essencialmente se baseiam no axioma da democracia liberal. Esse pressuposto, consequentemente, gera a exclusão de certas conformações que desafiam o modelo liberal. Conclui-se, em linhas gerais, que há relutância em atribuir o “título” de democracia para formas de governo que não adotam como pressuposto uma visão de mundo liberal, porém, essa timidez acaba por ignorar a própria lógica da contestabilidade e constitui uma falácia diante do próprio pressuposto de variabilidade no qual se baseia.
Pengaruh Komunikasi Interpersonal Salesman, Harga, dan Produk Kompetitor terhadap Keputusan Pembelian Produk Kopiko di Costumer Base Retail
Authors: Saputro Andri Mei , Riawan Riawan , Kristiyana Naning
Published: December 2023

Penelitian ini bertujuan untuk Pengaruh Komunikasi Interpersonal Salesman, Harga dan  Produk Kompetitor terhadap Keputusan Pembelian Produk Kopiko di Costumer Base Retail CV. Tirta Raharja Kantor Cabang Ponorogo serta untuk mengetahui pengaruh Komunikasi Interpersonal Salesman, Harga dan Produk Kompetitor secara simultan terhadap Keputusan pembelian konsumen pada produk Kopiko di Costumer Base Retail CV. Tirta Raharja Kantor Cabang Ponorogo. Populasi dalam penelitian ini adalah Costumer Base Retail di CV. Tirta Raharja Kantor Cabang Ponorogo yang pernah melakukan pembelian. Jumlah sampel yang diambil sebanyak 78 responden. Data dan hasil responden tersebut di olah menggunakan SPSS. Hasil penelitian menunjukan bahwa Komunikasi Interpersonal Salesman (X1) berpengaruh signifikan terhadap Keputusan Pembelian Costumer Base Retail (Y), Harga (X2) berpengaruh signifikan terhadap Keputusan Pembelian Costumer Base Retail (Y), dan Produk Kompetitor (X3 berpengaruh signifikan terhadap Keputusan Pembelian Costumer Base Retail (Y) di CV.
Miranda: cultura griega, estudios clásicos, relación con Andrés Bello
Authors: Didier Miguel Castillo
Published: December 2023

Francisco de Miranda (1750-1816), precursor, herói e mártir da Independência da América Hispânica, estudou a língua grega e reuniu uma vasta biblioteca, com mais de 170 autores gregos. A idéia de liberdade para a américa espanhola surgiu nele em 1781, ligada a sua profunda admiração pela Grécia, na qual nasceu a liberdade. Aí está porque em sua longa viagem através da Europa, em 1786, apesar das ameaças e dos perigos, ele viajou para a Grécia, que gemia sob a dominação otomana. Ele desejava conhecer os lugares onde haviam nascido as idéias de liberdade e democracia, onde um pequeno povo havia vencido um gigantesco império absolutista. Miranda visitou o Pireu, Atenas, Corinto, Salamina, Maratona e depois Esmirna e Constantinopla. Escreveu um jornal muito interessante de sua viagem à Grécia. Em 1792, Miranda serviu na França, quando a Revolução Francesa ainda não tinha abandonado os ideais libertários. Lá, Miranda defendeu os princípios republicanos e a divisão dos poderes, invocando não Montesquieu, mas o exemplo da Grécia antiga. Pedro Grase iniciou com Miranda seu estudo da tradição humanista na América Latina e prossegue com Andrés Bello (1781-1816), o grande sábio que estudou a língua grega na biblioteca de Miranda, em Londres, e que se tornou latinista e helenista. Bello compartilha de sua convicção de que o estudo do latim e do grego e da cultura clássica está na base de toda a cultura sólida.
Tradición Clásica en Iberoamérica
Authors: De Tobia Ana María González
Published: December 2023

A tradição clássica na América Latina mostra a relação dos países sulamericanos com a Europa ocidental do ponto de vista da vinculação estritamente cultural. O presente estudo inclui dezoito países de língua espanhola, um de língua portuguesa e, sob um certo aspecto, Porto Rico. Indicam-se três etapas culturais, que mostram diferentes incidências da Antiguidade clássica na América Latina. São elas: 1. Conquista; 2. Independência; 3. Século XX em diante. A América Latina se constitui no mito da utopia descoberta pela Europa e conserva em sua essência vital o sentimento utópico pela busca constante da unidade na pluralidade.
Permanenza di motivi proverbiali classici nelle culture moderne: alcuni esempi
Authors: Tosi Renzo
Published: December 2023

Muitos provérbios que ora circulam nas diversas línguas européias têm antecedentes clássicos. Às vezes é possível traçar uma linha de continuidade entre o mundo grego clássico ou mesmo entre o mundo do Oriente Próximo e as modernas literaturas; outras vezes, os provérbios modernos originam-se de um tópos clássico modificado durante o período medieval e podem, inclusive, utilizar uma nova imagem ou podem exibir um desvio semântico quando comparados com o original. Por fim, a difusão dos antigos provérbios no mundo moderno pode dever-se ao fato de que foram reutilizados durante o Humanismo. Essa é a forma mais comum (mas não a única!) pela qual os provérbios e modos de expressão da época clássica passaram a fazer parte do patrimônio moderno dos provérbios. Um último caso digno de menção é o das muitas passagens famosas da Literatura Latina que, recebida como máximas, adquiriram um valor proverbial, às vezes com variações e enganos.
Resenha de LESSA, F. de S. O feminino em Atenas. Rio de Janeiro: Mauad, 2005, 221p.
Authors: Barbosa Virgínia Ribeiro
Published: December 2023

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Giovenale e la società del suo tempo
Authors: Vitorino Mônica Costa
Published: December 2023

Muitos estudos sobre as sátiras de Juvenal propõem o problema do valor de testemunha do poeta em relação ao momento histórico contemporâneo. Alguns insistem em utilizar como chave de leitura elementos biográ?cos supostamente presentes na obra, outros reduzem as críticas sociais a uma espécie de virtuosismo oratório da parte de Juvenal. O artigo pretende criticar essas posições que, além de empobrecedoras, di?cultam uma interpretação pertinente da obra.
Remexendo cartas novas e velhas, encontrando o inesperado. Uma análise comparativa dos textos de Mariana, Ovídio e as Três Marias
Authors: Krempser Ciomara Breder
Published: December 2023

Este artigo adota como metodologia a pesquisa bibliográfica comparativa, tendo como objetivo a construção de um painel epistolográfico entre as Cartas portuguesas de Mariana Alcoforado, as Heroides de Públio Ovídio Naso e as Novas cartas portuguesas de Maria Isabel Barreno, Maria Teresa Horta e Maria Velho da Costa, priorizando o aspecto temático da enunciação feminina. Nossa análise aborda a questão do gênero epistolográfico, da escrita como exercício de fruição estética – o prazer do texto – e da reivindicação de um discurso fragmentário que conduz ao “inesperado”. Tal categoria casa-se com a enunciação feminina para desconstruir o discurso falocêntrico e logocêntrico.
O bárbaro logrado em Aristófanes e Eurípides
Authors: Duarte Adriane da Silva
Published: December 2023

Neste artigo buscou-se investigar a inter-relação entre tragédia e comédia tendo em vista o exame da personagem do bárbaro logrado na comédia As tesmoforiantes, de Aristófanes e nas tragédias Ifigênia em Tauris e Helena, de Eurípides. Examina-se a hipótese de que o comediógrafo, no êxodo d’As tesmoforiantes, tenha recorrido intencionalmente à figura do bárbaro logrado, de modo a evocar os finais das tragédias referidas e como a presença dessa personagem afetou a recepção das peças.
Editorial
Authors: Martins Paulo , Prado João Batista Toledo
Published: December 2023

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Cuerpo y corporeidad en la tragedia griega
Authors: Gambon Lidia
Published: December 2023

Starting from considerations about the centrality of the body and corporeity in Greek tragedy, this paper focuses on Euripides’ tragedy Hippolytus. The analysis of these topics in the play shows that Euripides gives prominence to the female body, presenting Phaedra in a new and disruptive way, not only in suffering, but also in her death.
Normas Editoriais
Authors: Editorial Conselho
Published: December 2023

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Research on village classification and development based on particle swarm optimization model: Xiecun Township, Yuanping City, in Shanxi Province, China
Authors: Ma Xiaoting , Utaberta Nangkula , Zainordin Nadzirah
Published: December 2023

China’s village development confronts substantial challenges, inefficient land use due to the scattered village layout, sluggish development of village industries, and lack of proper planning for village development and construction, etc. Scientific classification of villages and village-based policy is the key to address these challenges. This study employs cell phone signaling big data to construct a population flow model based on particle swarm optimization algorithm This model takes into account spatial driving force and social connection strength as dual conditions. Also, it analyzes the settlement redistribution optimization scheme under the model through empirical research on Xiecun Township of Yuanping City, Shanxi Province, in order to classify villages scientifically and apply different strategies to village development according to the classification results. The findings of the study indicate that the area characterized by the densest distribution of optimized particle clusters, with good land conditions and high economic income, are classified as “cluster-enhanced villages”. Regions with the densest distribution of the initial particle distance factor and the densest distribution of optimized particle clusters are closer to the urban centers, which are better positioned to take advantage of the city’s financial and technological resources and continuously improve the added value of agricultural products, so they are classified as “peri-urban integrated villages”. Areas characterized by sparse distribution of optimized particle clusters need to actively cultivate the advantageous and characteristic industries in the countryside, and bolster transportation conditions and the protection of local culture, so as to realize the green development of urban and rural regional economy. Such areas are classified as “characteristic conservation villages”. In areas without optimized particle cluster distribution or areas with extremely sparse distribution of optimized particle clusters, the rational layout of urban and rural settlement spatial organization should be vigorously promoted, with emphasis on the enhancement of ecological environment, and they are classified as “relocated and annexed villages”. According to the results of village classification, corresponding strategies to promote the development of different types of villages are proposed in terms of spatial optimization, industrial upgrading and planning.
Pseudocarcinomatous Hyperplasia of Tubal Mucosa Associated With Chronic Salpingitis – Clinical And Pathological Challenge: A Case Report
Authors: Bulikj Snezhana , Kalamaras Milica , Jasar Dzengis , Sabit Katerina Kubelka , Dimitrov Gligor , Ivanovski Mitko , Palchevska Eva , Topencharova Jovana
Published: December 2023

Pseudocarcinomatous hyperplasia of the tubal mucosa is a rare, reactive response to an underlying inflammatory or neoplastic process. We present a case of pseudocarcinomatous hyperplasia in a 26-year-old woman with clinical symptomatology of pelvic inflammatory disease, and a normal serum Ca 125-level (30 U/ml). The ultrasound finding showed presence of hydrosalpinx characterized with unilateral tubal enlargement in sausage-like shape that arose from the upper lateral margin of the uterus. The young age of the patient, presence of chronic inflammation, epithelial hyperplasia with unremarkable nuclear atypia and mitosis facilitated the right diagnosis. Pseudocarcinomatous hyperplasia can mimic neoplastic processes clinically and pathologically. Differential morphological and clinical features should be considered to ensure accurate diagnosis and proper management.
”Vi får lära oss helt nya sätt att tänka nu!”
Authors: Jansson Hydén Katarina
Published: December 2023

This study investigates the potential to encompass questions about transgender and gender fluid identity in the school subject visual art in compulsory school years 7-9. A qualitative semi structured focus group interview was made with five visual art teachers who discuss visual art in relation to its potential to support personal development, exploration of identity and gender orientation in art education. The article discusses in what way visual art as a school subject can function as communicative support for pupils withgender fluid identity and in what way transgender individuals and individuals with gender fluid identity can be included in the arteducation in school. The results show that the visual art teachers believe that the subject visual art is a significant tool for pupils in communicating an inner dialogue with an external world. The results also show that multimodal methods give pupils the opportunity tobe exploratory and uncertain as well as support them in communicating what is unsaid and unwritten when exploring ongoing changes in gender identity. Visual arts can thus be a forum for pupils to talk about questions concerning transgender and gender fluid identification and serve as a democratic tool to counteract exclusion.
Dynamics of laboratory markers of systemic inflammation in neurosurgical operations using α-2-adrenoagonists
Authors: Lesteva N. A. , Dryagina N. V. , Kondratiev A. N.
Published: December 2023

The objective was to study the degree of deviations of laboratory parameters of the systemic inflammatory response syndrome (SIRS) under the conditions of modulation of the reactions of the sympathetic nervous system by various α-2-adrenergic receptors during neurosurgical interventions for the removal of the brain tumor of subtentorial localization

Materials and methods. The laboratory data of 179 patients operated for the brain tumor of subtentorial localization were analyzed. The operations were performed under conditions of total intravenous anesthesia. The patients were divided into two groups depending on the α-2-adrenergic agonist used in the structure of the anesthetic aid: clonidine was used in the first group, dexmedetomidine was used in the second group. Laboratory tests included analysis of the levels of cytokines (IL-8, IL-6, IL-10, TNF-α), CRP, fibrinogen. Blood sampling for the study was carried out in five stages: 1 – one day before the operation, 2 – on the day of the operation before the introductory anesthesia, 3 – after the induction anesthesia, 4 – after removal of the tumor (at the stage of hemostasis); 5 – on the first day after surgery.

Results. The dynamics of laboratory parameters were similar in both study groups and reflected the manifestations of the systemic inflammatory response of the body to intracranial intervention. The levels of pro-inflammatory cytokines IL-6, IL-8, TNF-α, and C-reactive protein (CRP) increased in the fourth and fifth stages of the study. The increase in the level of IL-6 and fibrinogen in the fifth stage of the study in the second group was more significant, which was explained by the less pronounced anti-inflammatory effect of dexmedetomidine compared to clonidine.

Conclusions. Changes in laboratory parameters of SIRS as the reaction to surgical intervention on the brain were transient. Under conditions of total intravenous anesthesia with the use of α-2-adrenergic agonists, modulation of the inflammatory response was demonstrated, which ensured adequate consistency of the inflammatory process.
Medical student syndrome in Saudi Arabia; a cross-sectional study
Authors: Mohamed Khalid , Albelowi Ahmed , Alruhily Aseem , Ternati Mohammad , Saleh Mohammed , Alfagi Ahmed
Published: December 2023

Objective:
This study aimed to investigate the prevalence of medical student syndrome (MSS) in Saudi Arabia by collecting samples from multiple universities.
Methods:
This was a cross-sectional questionnaire based study that included 347 medical students from multiple universities across Saudi Arabia. The questionnaire consisted of sociodemographic data and an 18-questions version of the Health Anxiety Inventory (HAI) score.
Results:
The study results showed that 7.5% medical students had MSS. It also showed that students aged 21 years or less had significantly higher median scores than those aged more than 21 years, according to the HAI. This study also showed that the prevalence of MSS among medical students with medical diseases was significantly higher than those without a history of medical disease.
Conclusion:
MSS was prevalent among medical students in Saudi Arabia. Several factors have been found to play a role in the development of the disease.
Uso de indicadores ambientales para la construcción de una herramienta como estrategia administrativa de mejora en la gestión ambiental y la toma de decisiones en torno a la sostenibilidad
Authors: Ardila Linares Ivan Giovanni , Molina Tilano Ruby Sandrid , Fonseca Zaraza Erika
Published: December 2023

El sector económico y productivo ha generado en las últimas décadas una preocupación inminente por los impactos negativos al medio ambiente, lo cual ha concebido en la sociedad y en las empresas comprendidas en este sector, la búsqueda de indicadores de gestión ambiental que evalúen el escenario empresarial para priorizar la acción de responsabilidad social y ambiental. La herramienta de gestión de desempeño de proveedores es uno de estos instrumentos de gestión integrada, que evalúa los esfuerzos presentados en un seguimiento, a lo largo de una metodología basada en el “Supplier Performance Management” de ENEL. Los resultados evidencian una herramienta que permite a los actores una visualización apropiada de las circunstancias de cada empresa y a la toma de decisiones en el marco de la sostenibilidad empresarial.
Estudiantes universitarios en la era digital: las oportunidades y amenazas del entretenimiento por internet y las actividades financieras en línea
Authors: Aguilar Barcerlo Jose Gabriel , Palacio Iriarte Steven de Jesus , Garay Lopez Adriana Lucia , Cazeres Rodriguez Mauricio
Published: December 2023

Las nuevas tecnologías han traído consigo cambios en el comportamiento humano en todos los órdenes. La presente investigación tiene como objetivo identificar las oportunidades y amenazas de actividades en línea relacionadas con el entretenimiento, las herramientas financieras y los activos especulativos, las cuales son cada vez más comunes entre estudiantes de educación superior; incluso, destacando la posibilidad de aprovecharlas para acelerar y optimizar el aprendizaje sobre finanzas conductuales y gestión de riesgo. El estudio se soporta en bibliografía de autores especializados y en un cuestionario realizado a una muestra de 102 personas. Se encontró que una parte significativa de los jóvenes está participando o tiene interés en participar en actividades especulativas, llevados entre otras razones, por la idea de hacer crecer su dinero de manera rápida. Lo anterior los pone en riesgo de sufrir pérdidas de capital económico o social, o presentar algunos comportamientos que podrían requerir atención. De igual forma, se hacen algunas recomendaciones para mantener prácticas y conductas saludables frente a estas actividades.
Eucalyptus and spearmint oils inhibit the biological activity of lesser grain borer and red flour beetles
Authors: Ali Azher M. , Sabit Falah A.
Published: December 2023

The objective of this investigation was to assess the insecticidal efficacy of essential oils derived from eucalyptus (Eucalyptus camaldulensis) and spearmint (Mentha spicata) against two species of stored-product insects. The process of Clevenger-type water distillation was employed to extract essential oils from two distinct plant species. Subsequently, the insecticidal properties of these oils were evaluated against specimens of the American wheat weevil (Rhyzopertha dominica) and the red flour beetle (Tribolium castaneum), belonging to the Coleoptera: Bostrichidae and Tenebrionidae families, respectively. Eucalyptus oil exhibited the highest level of inhibition of insects’ reproduction. Still, when tested on adults of both types of insects, eucalyptus and spearmint oils were more effective than the control treatment. A complete inhibition of egg-laying activity (100%) was achieved using a 7% concentration of eucalyptus oil. The trials were done within controlled laboratory settings, with a notable absence of tests conducted under authentic operational conditions. Researchers who want to learn more about using essential oils as insecticides in the future should focus on making pesticide formulations that work well in a wide range of production settings.
ENSAIOS FÍSICOS DE QUALIDADE DE COMPRIMIDOS GENÉRICOS E DE REFERÊNCIA DE CLORIDRATO DE PROPRANOLOL
Authors: Lima Francisco Wallison Barbosa de , Bezerra Gabrieli da Penha , Arruda Carlos André Moura
Published: December 2023

O controle de qualidade constitui um conjunto de operações com intuito de averiguar e atestar a conformidade de medicamentos com as monografias estabelecidas pela Farmacopeia Brasileira. Aliada ao cumprimento das Boas Práticas de Fabricação (BPF), a avaliação das propriedades físicas de produtos farmacêuticos pode proporcionar a comercialização de medicamentos de qualidade, seguros e eficazes. O cloridrato de propranolol é um anti-hipertensivo do tipo betabloqueador disponível para prescrição no Brasil também como medicamento genérico, devendo estar de acordo com os parâmetros estabelecidos pelos compêndios oficiais. Para avaliar a qualidade física de comprimidos de referência e genéricos de cloridrato de propranolol (40 mg) dispensados em uma farmácia comunitária de Fortaleza, realizou-se um estudo experimental por meio das análises de peso médio, dureza, friabilidade e desintegração, conforme o preconizado pela Farmacopeia Brasileira 6ª Edição. As amostras utilizadas neste trabalho foram separadas em grupos designados por ‘R’ para os medicamentos de referência e ‘G’ para os medicamentos genéricos. Os dois grupos foram avaliados em triplicata, por análise estatística descritiva. Ao final dos ensaios, foi observado que as amostras avaliadas atenderam às especificações farmacopeicas quanto aos parâmetros físicos de qualidade, cumprindo, dessa forma, parte dos requisitos necessários à demonstração de equivalência farmacêutica requeridos pela Agência Nacional de Vigilância Sanitária (ANVISA).
Perfil epidemiológico de pacientes com doenças renais atendidos em uma clínica especializada
Authors: Souza Filho Manoel Dias de , Martins Lucas de Oliveira , Santos Álison Machado , Costa Ana Clara Coelho da , Braga Rízia Laysa Soares , Leódido Ana Carolina Machado
Published: December 2023

Objetivo: Descrever o perfil epidemiológico de pacientes atendidos em uma instituição particular conveniada ao Sistema Único de Saúde, especializada no tratamento de doenças renais. Métodos: Foi realizado um estudo quantitativo, descritivo e retrospectivo, utilizando prontuários com informações sobre o perfil de pacientes submetidos a tratamento nefrológico, em Parnaíba, Piauí, Brasil. Resultados: Foram obtidas informações de 245 pacientes em tratamento dialítico. A análise dos prontuários mostrou que a maioria era do sexo masculino (62,5%); com idade entre 40 e 80 anos (78,4%); média de idade de 53,7 ± 14,5 anos; pardos (82%); naturais dos Estados do Piauí (60,8%), Maranhão (28,2%) ou Ceara (7,8%) e não portadores de diploma de curso superior (59,6%), sendo todos usuários do SUS. Ademais, uma parte significativa dessa população apresentava, além da Doença Renal Crônica, comorbidades como hipertensão (34,7%); edemas nos membros inferiores ou face (23,7%); relação entre os íons cálcio e fósforo alterada (22,9%); anemia (22,5%) e diabetes (15,5%). Conclusão: O perfil dos pacientes que necessitam de tratamento renal atendidos em Parnaíba, em especial o tratamento dialítico, é complexo, havendo, assim, a necessidade do maior incentivo às políticas públicas de saúde que priorizem a prevenção das doenças nefrológicas e das comorbidades associadas.
January air palaeotemperature during MIS-3-2 in North-Eastern Yakutia, reconstructed from a high-resolution record of the isotopic composition of syngenetic ice wedges of the Batagay Yedoma
Authors: Vasil’chuk Y.K. , Vasil’chuk A.C. , Budantseva N.A. , Vasil’chuk J.Y.
Published: December 2023

The work is aimed at determining the age of ice wedges, as well as at characterizing winter temperature fluctuations during the formation of the Yedoma based on the isotopic composition of ice wedges in the unique outcrop of the Batagay mega-slump. The researchers carried out a detailed sampling from the Upper Ice Wedge Complex of the Batagay Yedoma, determined the isotopic composition in three ice wedges at different altitudes. The results of radiocarbon dating of organic matter from ice wedge confirm the time of syngenetic formation of the upper-tier ice wedges in the range from 27.2 to 30.8 thousand cal. years. Ice wedges of the lower tier, according to the results of radiocarbon dating of ice accumulated 44.7—47.9 thousand years ago simultaneously at different levels: 274—268 m and 224—227 respectively. The study of yedoma deposits and ice-wedge ice made it possible to obtain data on climatic fluctuations in a region with the most severe continental climate. Direct radiocarbon dating of syngenetic ice wedges provided dating of ice growth in the Batagay yedoma, data on the content of stable isotopes in the ice demonstrated stable and very harsh conditions of the winter season. The air paleotemperature in Batagay in January 47—42 and 30—25 thousand cal. years ago was consistently low about –51°C.
Radiation situation around the floating nuclear thermal power plant “Akademik Lomonosov” in the initial period of operation
Authors:   Institute of Industrial Ecology, Ural Branch of the RAS, Ekidin A.A. , Nazarov E.I. ,   Institute of Industrial Ecology, Ural Branch of the RAS, Antonov K.L. ,   Institute of Industrial Ecology, Ural Branch of the RAS
Published: December 2023

The article considers the issues of energy supply to remote sparsely populated Arctic regions of the Russian Federation through the construction of low-capacity nuclear power plants. The effectiveness of this approach is demonstrated by the successful commissioning in 2019 of a unique floating power plant in the town of Pevek (FNPP Akademik Lomonosov). At the same time, the operation of such facilities raises questions from the local population about possible radioactive contamination of the territory. The absence of a negative impact of FNPP can be confirmed by comparing the radiation characteristics before and after commissioning, as well as by direct measurements of the soil radionuclide composition in the zone of possible impact. To search for changes in the radioecological situation in 2021, screening studies were carried out at the plant location area. An analysis of the monitoring data for radioactive fallout and dose rate in Pevek showed that external exposure from the surface of soil and soil is due only to natural radionuclides of the decay chains of uranium, thorium and 40K. Artificial radionuclides characteristic of NPP emissions were not found in the surveyed areas. The range of values and maximum dose rate levels (µSv/h) before and after commissioning of the FNPP do not differ from each other and coincide with the results of the performed screening assessment of the radiation situation. The results were discussed with the residents of Pevek. The results of the study make it possible to inform the public about the absence of changes in the radiation situation at the FNPP location area in the first years of operation.
On the possibility of extending the service life of winter roads using renewable energy sources
Authors:   Bauman Moscow State Technical University, Loktionov E.Y. , Sharaborova E.S. ,   École Polytechnique Fédérale de Lausanne, Klokov A.V. ,   Bauman Moscow State Technical University, Bakhmadov A.V. ,   Bauman Moscow State Technical University, Korshunov A.A. ,   M. V. Lomonosov Northern (Arctic) Federal University
Published: December 2023

It is hard to overestimate the role of winter roads in the land logistics of the northern regions. In recent years, climate change has not only significantly reduced the service life of winter roads, but also made them less predictable. This forces transportation to increase in intensity, often at the expense of safety, or to stop that suddenly, leaving vehicles and equipment unused for long periods and disrupting project deadlines. Therefore, extending the service life of winter roads and reducing dependence on local weather conditions is a very urgent task. To solve it, we considered the possibility of applying our previously proposed method of thermal stabilization of frozen ground using solar panels and heat pumps, and estimated the associated costs. Our calculations have shown that it is possible to extend significantly the service life of unpaved winter roads, up to year-round use, in the case of using the most lightweight road pavement without creating a cushion. The approach can contribute to solving a whole range of problems of sustainable development of the Russian Arctic territories by creating transport and energy corridors.
On trends in environmental and climatic risks for human health in the Arctic zone of Russia under climate change
Authors:   A.M.Obukhov Institute of Atmospheric Physics Russian Academy of Sciences, Makosko A.A. , Matesheva A.V. ,   A.M.Obukhov Institute of Atmospheric Physics Russian Academy of Sciences, Emelina S.V. ,   Hydrometcenter of Russia
Published: December 2023

The authors explore the dynamics of human health risks caused by air pollution and weather and climate comfort in the Arctic zone of Russia in 2020-2050 under two climate change scenarios (RCP4.5 and RCP8.5). According to estimates, in the period up to 2050, there is generally an insignificant dynamics of risks characterized by inter-scenario variability and dispersion across the territory of the Russian Arctic. Only in certain areas there are noticeable trends. Under the RCP4.5 scenario, a significant area of the Arctic shows a trend towards increased health risks from air pollution and improved weather and climate comfort in spring and summer. In winter and autumn, in some Arctic regions of the ETR (European territory of Russia) and Siberia, increased cold discomfort is possible. Under the RCP8.5 scenario, there is a tendency to reduce the risk from air pollution in most areas, and improve comfort in almost the entire territory of the Russian Arctic in spring, in most of the subarctic zone — in other seasons, in the temperate zone — in summer. A trend towards increased cold discomfort is noted in large areas of the Arctic zone in winter, summer and autumn, in certain areas of the European territory of Russia and Siberia in the temperate zone — in autumn and winter, in the subarctic zone — in autumn. The authors outline the need for additional attention when planning measures to adapt to climate change in the territories of the Yamalo-Nenets Autonomous Area and the Krasnoyarsk Territory. The findings are relevant for strategic planning of the development of Arctic territories, environmental and climatic risks management for the population living and working in the Arctic.
Experience of introduction of musk oxen to Zavyalov Island in Tauiskaya Bay of the northern part of the Sea of Okhotsk
Authors:   Institute of Biological Problems of the North FEB RAS, Gorshunov M.B.
Published: December 2023

The paper describes the process of the beginning of the formation of a population of musk oxen (ovibos moschatus) on Zavyalov Island, peculiarities of adaptation to one of the southernmost habitats with a high density of brown bear population. The purpose of the musk oxen introduction is connected with the implementation of the Arctic Development Strategy and the search for new opportunities of the national economy. Provided that the minimum impact of predators on the population of Zavyalov Island is ensured, it is necessary to prevent a catastrophic increase in the number, which inevitably leads to a shortage of feed. Thus it will be necessary to relocate excess animals. The introduction of musk oxen corresponds to the tourism development plan, and will also serve as an additional, environmentally safe factor in the economy and food independence of remote territories. At the beginning of autumn 2018, 25 musk oxen were brought to Zavyalov Island; all of them were one year old. On the island, musk oxen were initially kept in paddok. On September 10, 2020, another 25 musk oxen were brought. During the first two years, the sex-age structure depended only on their death. Four (4) individuals survived: two (2) males and two (2) females, the strong predation of the brown bear affected. One of them gave offspring in the third year: one calf appeared. In the fourth year, both females from the first delivery gave birth to a calf. Now the island is optimizing the sex-age structure of the musk ox population. But the main patterns of the formation of the population of musk oxen for other islands won’t work on Zavyalov Island due to relatively high number of brown bears, which does not allow the population to develop in the same way as in other habitats, with a much lower density of this predator. The introduction of musk oxen to Zavyalov Island, with good protection from predators, shows a positive result for the settlement of these animals in other similar territories.
A Molecular Dynamics Simulation Study of the Effects of βGln114 Mutation on the Dynamic Behavior of the Catalytic Site of the Tryptophan Synthase
Authors: Roy Anupom , Karttunen Mikko
Published: December 2023

L-tryptophan (L-Trp), a vital amino acid for the survival of various organisms, is synthesized by the enzyme tryptophan synthase (TS) in organisms such as eubacteria, archaebacteria, protista, fungi, and plantae. TS, a pyridoxal 5′-phosphate (PLP)- dependent enzyme, comprises α and β subunits that typically form an α2β2 tetramer. The enzyme’s activity is regulated by the conformational switching of its α and β subunits between the open (T state) and closed (R state) conformations. Many microorganisms rely on TS for growth and replication, making the enzyme and the L-Trp biosynthetic pathway potential drug targets. For instance, Mycobacterium tuberculosis, Chlamydiae bacteria, Streptococcus pneumoniae, Francisella tularensis, Salmonella bacteria, and Cryptosporidium parasitic protozoa depend on L-Trp synthesis. Antibiotic- resistant salmonella strains have emerged, underscoring the need for novel drugs targeting the L-Trp biosynthetic pathway, especially for salmonella-related infections. A single amino acid mutation can significantly impact enzyme function, affecting stability, conformational dynamics, and active or allosteric sites. These changes influence interactions, catalytic activity, and protein-ligand/protein-protein interactions. This study focuses on the impact of mutating the βGln114 residue on the catalytic and allosteric sites of TS. Extensive MD simulations were conducted on E(PLP), E(AEX1), E(A-A), and E(C3) forms of TS using the WT, βQ114A, and βQ114N versions. The results show that both the βQ114A and βQ114N mutations increase protein backbone RMSD fluctuations, destabilizing all TS forms. Conformational and hydrogen bond analyses suggest the significance of βGln114 drifting away from cofactor/intermediates and forming hydrogen bonds with water molecules necessary for L-Trp biosynthesis. The βQ114A mutation creates a gap between βAla114 and cofactor/intermediates, hindering hydrogen bond formation due to short sidechains, disrupting β-sites. Conversely, the βQ114N mutation positions βAsn114 closer to cofactor/intermediates, forming hydrogen bonds with O3 of cofactors/intermediates and nearby water molecules, potentially disrupting the L-Trp biosynthetic mechanism.
Facial Selectivity in Mechanical Bond Formation: Axially Chiral Enantiomers and Geometric Isomers from a Simple Prochiral Macrocycle
Authors: Savoini Andrea , Gallagher Peter , Saady Abed , Maynard John , Butler Patrick , Tizzard Graham , Goldup Stephen
Published: December 2023

In 1971, Schill recognized that a prochiral macrocycle encircling an oriented axle led to geometric isomerism in rotaxanes. More recently, we identified an overlooked chiral stereogenic unit in rotaxanes that arises when a prochiral macrocycle encircles a prochiral axle. Here we show that both stereogenic units can be accessed using equivalent strategies, with a single weak stereo-differentiating interaction sufficient for reasonable stereoselectivity. Using this understanding, we were able to demonstrate the first direct enantioselective (70% ee) synthesis of a mechanically axially chiral rotaxane.
Accessing the Electronic Structure of Liquid Crystalline Semiconductors with Bottom-Up Electronic Coarse-Graining
Authors: Wang Chun-I , Maier Charlie , Jackson Nicholas
Published: December 2023

Understanding the relationship between multiscale morphology and electronic structure is a grand challenge for semiconducting soft materials. Computational studies aimed at characterizing these multiscale relationships require the complex integration of quantum-chemical (QC) calculations, all-atom and coarse-grained (CG) molecular dynamics simulations, and back-mapping approaches. However, the integration and scalability of these methods pose substantial computational challenges that limit their application to the requisite length scales of soft material morphologies. Here, we demonstrate the bottom-up electronic coarse-graining (ECG) of morphology-dependent electronic structure in the liquid-crystalline (LC) semiconductor, 2-(4-methoxyphenyl)-7-octyl-benzothienobenzothiophene (BTBT). ECG is applied to construct density functional theory (DFT)-accurate valence band Hamiltonians of the isotropic and nematic LC phases using only the CG representation of BTBT. By bypassing the atomistic resolution and its prohibitive computational costs, ECG enables the first calculations of the morphology dependence of the electronic structure of charge carriers across LC phases at the ~20 nm length scale, with robust statistical sampling. These simulations uncover a complex interplay of localized and delocalized charge carriers in the isotropic and nematic LC phases while highlighting the important role of statistical sampling in the electronic structure of soft materials. Importantly, to push towards electronic predictions at truly mesoscopic length scales, we assess the theoretical feasibility of developing field-based ECG models. The fully CG approach to electronic property predictions in LC semiconductors opens a new computational direction for designing electronic processes in soft materials at their characteristic length scales.
Biofabrics from Sodium Alginate
Authors: Farhan Mohammad
Published: December 2023

This was a study meant to understand the properties and nature of biofabrics made with the help of sodium alginate, which is an extract of brown seaweed, sodium alginate as a substance is often used for baking purposes. The research aimed at the making of biofabrics from many different organic and inorganic materials like tea, beetroot, coffee, sugar, water, colored water and even salt water. The study aims at understanding and taking a step further at progressing the development of sustainable fabrics. Our biofabrics showcase the potential to significantly reduce the environmental impact associated with conventional textile manufacturing. Its properties can be customized to cater to a wide array of applications.
Effect of tea tree oil on candida adherence and surface roughness of heat cure acrylic resin
Authors: Noori Zahraa S , Al-Khafaji Aseel M , Dabaghi Fatemeh
Published: December 2023

Background: Denture cleansing was an important step that could prevent the spread of infection and improve a patient's health, the durability of the dentures, and the overall quality of life; therefore, it was necessary to choose a suitable cleanser that, in addition to being effective, did not have an unfavorable effect on the qualities of the denture base resin itself when used for an extended period. For this purpose, this study aimed to evaluate the effect of tea tree oil (TTO) on Candida albicans adhesion and the surface roughness property of poly(methyl methacrylate) denture material after immersion in TTO. Methods: A total of 55 heat-cured acrylic resin specimens were used for C. albicans adherence and surface roughness tests. They were distributed into groups (0.25%, 0.5%, 0.75%, and 1%) of TTO, distilled water (DW), and 2% clorhexidine digluconate, totaling five specimens for each group. The specimens were immersed in accordance with their group for 10 minutes. Surface roughness was determined by a profilometer, and C. albicans adherence was determined by measuring optical density with a spectrophotometer. For comparisons between groups for surface roughness and disinfection tests, one-way ANOVA was performed on SPSS program, considering α = 0.05. Results: TTO had a statistically significant effect on C. albicans adhesion to heat-cured acrylic resin (P < 0.05) compared with negative control. Meanwhile, no statistically significant difference was found between 0.75% and 1% TTO concentrations (P > 0.05), whereas the surface roughness test showed a statistically non-significant difference between TTO concentrations and DW (P > 0.05). Conclusions: Immersion of acrylic resin in TTO was effective in decreasing C. albicans adhesion to it, and the greatest decrease was obtained by 1% TTO. The surface roughness test showed a non-significant difference in acrylic roughness after immersion in TTO.
Educational Forum
Authors: Roth H
Published: December 2023

Advanced notice of 1978 Annual General Meeting of the Industrial Relations Society of New Zealand, worker participation - employee involvement
Industrial Law Cases
Authors: Hodge Bill
Published: December 2023

Review of 1. Wellington Union of Advertising Workers Society v New Zealand Sales Advertising Representatives Guild I.U.W. Industrial Court, Wellington. 17 October, 1977. (I.C. 48177). Jamieson J.
2. MacKenzie (Inspector of Awards) v Rotorua District Veterinary Club Inc. Industrial Court, Rotorua. 29 March 1978 (I. C. 11 /78). Jamieson J.
3. O'Donnell v Ocean Beach Freezing Co. ltd Industrial Court, Dunedin. 29 March 1978 {I.C. 12/78). Jamieson J.
4. Airline Stewards and Hostesses of N.Z.I.U .W. v Air New Zealand Ltd. Industrial Court, Wellington. 15 May 1978 (A.C. 5/78}. Jamieson C.J.
5. The new arbitration court.
Role of innovation in economic growth in a New Zealand context
Authors: Little Struan
Published: December 2023

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The role of polytechnics in the innovation system
Authors: Sissons Linda
Published: December 2023

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