bluuebunny/crossref_metadata_2025 huggingface dataset:
Oncostatin M stimulates prostaglandin D 2 -induced osteoprotegerin and interleukin- 6 synthesis in osteoblasts
Authors: Kuroyanagi Gen , Hioki Tomoyuki , Tachi Junko , Matsushima-Nishiwaki Rie , Iida Hiroki , Kozawa Osamu , Tokuda Haruhiko
Published: August 2022

Oncostatin M produced by osteal macrophages has important roles in fracture healing. Osteoprotegerin (OPG) secreted by osteoblasts, binds to RANK ligand (RANKL) as a decoy receptor, and prevents RANKL from binding to RANK, resulting in the suppression of bone resorption. IL-6 is a pro-inflammatory cytokine and generally regulates bone resorption. However, accumulating evidence suggests that IL-6 plays pivotal roles in bone formation. We previously showed that prostaglandin D2 (PGD2) induces OPG synthesis by activating p38 mitogen-activated protein (MAP) kinase, stress-activated protein kinase/c-Jun N-terminal kinase (SAPK/JNK), and p44/p42 MAP kinase in osteoblast-like MC3T3-E1 cells. We also demonstrated that PGD2 stimulates IL-6 synthesis by activating p38 MAP kinase and p44/p42 MAP kinase in MC3T3-E1 cells. In the present study, we investigated whether oncostatin M affects PGD2-stimulated OPG and IL-6 synthesis in MC3T3-E1 cells through the MAP kinase activation. The osteoblast-like MC3T3-E1 cells were treated with oncostatin M and then stimulated with PGD2. OPG and IL-6 synthesis were measured using an OPG and IL-6 enzyme-linked immunosorbent assay kit. OPG and IL-6 mRNA expression levels were evaluated by real-time RT-PCR. The phosphorylation of p38 MAP kinase, SAPK/JNK, and p44/p42 MAP kinase were evaluated by Western blotting. As a result, oncostatin M significantly increased the PGD2-stimulated OPG and IL-6 release. Oncostatin M significantly enhanced mRNA expression levels of OPG and IL-6 induced by PGD2. Regarding the signaling mechanism, oncostatin M did not affect the phosphorylation of p38 MAP kinase, SAPK/JNK, and p44/p42 MAP kinase. Our results suggest that oncostatin M upregulates the PGD2-stimulated OPG and IL-6 synthesis in osteoblasts and therefore affect bone remodeling. However, OPG and IL-6 synthesis are not mediated through p38 MAP kinase, p44/p42 MAP kinase, or SAPK/JNK pathways.
Synthetic torpor protects rats from exposure to accelerated heavy ions
Authors: Puspitasari Anggraeini , Squarcio Fabio , Quartieri Martina , Totis Cristina , Hitrec Timna , Takahashi Akihisa , Yoshida Yukari , Hanamura Kenji , Yako Tomoko , Cerri Matteo , Simoniello Palma , Durante Marco , Tinganelli Walter
Published: August 2022

Hibernation or torpor is considered a possible tool to protect astronauts from the deleterious effects of space radiation that contains high-energy heavy ions. We induced synthetic torpor in rats by injecting adenosine 5′-monophosphate monohydrate (5′-AMP) i.p. and maintaining in low ambient temperature room (+ 16°C) for six hours immediately after total body irradiation (TBI) with accelerated carbon ions (C-ions). The 5′-AMP treatment in combination with low ambient temperature reduced skin temperature and increased survival following 8 Gy C-ion irradiation compared to saline-injected animals. Analysis of the histology of the brain, liver and lungs showed that 5′-AMP treatment following 2 Gy TBI reduced activated microglia, Iba1 positive cells in the brain, apoptotic cells in the liver, and damage to the lungs, suggesting that synthetic torpor spares tissues from energetic ion radiation. The application of 5′-AMP in combination with either hypoxia or low temperature environment for six hours following irradiation of rat retinal pigment epithelial (RPE-J) cells delays DNA repair and suppresses the radiation-induced mitotic catastrophe compared to control cells. We conclude that synthetic torpor protects animals from cosmic ray-simulated radiation and the mechanism involves both hypothermia and hypoxia.
DFT Analysis And In-Vitro Studies Of Isoxazole Derivatives As Potent Antioxidant And Antibacterial Agents Synthesized via One- pot Methodology
Authors: Thakur Ajay , Verma Monika , Setia Parul , Bharti Ruchi , Sharma Renu , Sharma Ajay , Negi Neelam P. , Anand Vivek , Bansal Ravi
Published: August 2022

Isoxazole and its derivatives derived from natural resources are very few. However, they have several applications in pharmaceutical industries, including antimicrobial, antitumor, anticancer, antifungal, and antibacterial activities. As a result, this research aimed to design a novel one-pot green approach to synthesize new oxazole derivatives. The derivatives were further explored for their antibacterial and antioxidant activities together with their DFT analysis. Characterization of newly synthesized moieties was done by IR, 1H NMR, 13C NMR, CHN analysis, & single-crystal X-ray Crystallography. Further, these compounds were examined for their antibacterial potential by using Gentamycin as a standard drug against S. aureus and E. colibacterial strains. The derivatives 4a, 4c, 4d, 4f, 4j, and 4k possessed excellent antibacterial potential against former, while 4c and 5 showed the highest activity against thelater one. The derivatives were also analyzed for their antioxidant activities by using free radical scavenging (ABTS. & DPPH assays), and Total antioxidant capacity (TAC). Here also, 4a, 4d, 4e, 4k, 4l, 4m, and 5 exhibited the most promising results. Finally, the density functional theory (DFT) analysis was achieved by using the B3LYP methodology with a 6-311+G(d,p) basis set to study the electronic structure of molecules and analysis of chemical reactivity descriptors such as hardness (η), Mulliken electronegativity (χ), chemical potential (μ) and electrophilicity (ω). These properties were calculated from the levels of the predicted frontier molecular orbitals and their energy gap.
Characterization of kefir yeasts with antifungal capacity against Aspergillus species
Authors: Moure María Candela , Torrado Roberto Pérez , Garmendia Gabriela , Vero Silvana , Querol Amparo , Alconada Teresa , Peláez Ángela León
Published: August 2022

Kefir is a fermented probiotic drink obtained by placing kefir granules in a suitable substrate. The kefir granules are a consortium of bacteria and yeasts embedded in a exopolysaccharide matrix. The aim of this research was the isolation and identification of yeasts from kefir of different origin, the evaluation of their antifungal capacity against Aspergillus spp. and the characterization of virulence related traits. Using RFLP of ITS1/ITS4 region, D1/D2 region sequencing and RAPD techniques, 20 kefir isolates were identified as Geotrichum candidum, Pichia kudriavzevii, P. membranifaciens, Saccharomyces cerevisiae and Candida ethanolica. Their antifungal capacity was evaluated by their conidia germination reduction, which allowed the selection of eight isolates with high to moderate conidia germination reduction against A. flavus and A. parasiticus. Furthermore, these selected isolates showed growth inhibition on contact in the dual culture assay for both Aspergillus species and 3 of them ‒belonging to S. cerevisiae and P. kudriavzevii species‒ generated volatile organic compounds which significantly affected the growth of both fungi. For the evaluation of virulence related traits, growth at high temperatures, enzymatic activities and the adhesion to Caco-2 cells were analyzed. The isolates did not present more than one positive virulence-related trait simultaneously. In particular, it is important to highlight that the adhesion capacity to the model of intestinal barrier was extremely low for all of them. According to the results obtained, further studies would be of interest for the possible use of these promising yeasts as biocontrol agents against fungi in food.
Linc01060 suppresses ferroptosis by downregulating SPOP-mediated c-Myc degradation in glioma
Authors: Li Jun Jun , Wang Qiang Ping , Jiang Cheng , Wang Min Jie , Tang Nan , Zhou Zi Jie , Zhu Kai , Cao Yu , Hu Guang Fu , Wang Si Qi , Shu Peng Wei , Yuan Hong Liang , Xiong Zhi Yong , Li Jin Song , Ouyang Tao Hui , Liu Hong Ya , Qiu Lie Wang , Wang Xuan , Li Lin , Hu Xue Bin , Zhang Fang Cheng , Zhou Ying Chun , Zhao Hong Yang , Rao Jing , Jiang Xiao Bing
Published: August 2022

Background:Ferroptosis is a type of regulated cell death induced by iron-dependent lipid peroxidation that plays an essential role in the pathogenesis of various diseases, including cancer. Previously, we reported that long non-coding RNA (lncRNA) Linc01060 regulates aggressive phenotype and aerobic glycolysis in glioma cells. However, the precise functions and underlying molecular mechanisms of Linc01060 in ferroptosis remain unknown.Methods:We explored the upstream regulatory mechanism of Linc01060 expression in hypoxic conditions in glioma cells. The expression and prognostic significance of Linc01060 in patients with glioma was analyzed using data from the Cancer Genome Atlas. The role of Linc01060 in regulating ferroptosis in glioma was evaluated bothin vitroandin vivo. Linc01060 expression in clinical glioma specimens was evaluated by fluorescence in situ hybridization, immunofluorescence, and immunohistochemistry.Results:Linc01060 expression was found to be transactivated by hypoxia inducible factor-1 alpha. A strong correlation was found between Linc01060 expression and ferroptosis biomarkers, suggesting that Linc01060 is a negative regulator of ferroptosis. Linc01060 rescued erastin-induced ferroptosis and promoted tumor progression in glioma cells bothin vitroandin vivo. Speckle-type POZ protein (SPOP), an E3 ligase of c-Myc, was identified as the target protein of Linc01060. We found that mechanistically Linc01060 competitively binds to SPOP, downregulating SPOP-mediated c-Myc degradation, and thereby decreasing the sensitivity of glioma cells to ferroptosis.Conclusion:Linc01060 suppresses ferroptosis by modulating the SPOP/c-Myc axis in glioma cells. Our results suggest that targeting Linc01060 is a potential strategy for the treatment of tumors.
Time series prediction of mine pressure in distributed optical fiber monitoring based on ARMA-SVR
Authors: Chai Jing , Wang Mingbo , Wang Anyi , OuYang Yibo
Published: August 2022

In this study, the distributed optical fiber is used to monitor the overburden changes during the coal mining process, and the average frequency shift change degree of optical fiber is introduced as the index to judge the periodic pressure. The ARMA-SVR model composed of auto-regressive moving average (ARMA) and support vector machine regression (SVR) is established to predict the rock pressure behavior through the prediction of the frequency shift change of optical fiber. Firstly, a similar material model is built to obtain the data of the frequency shift of the optical fiber during the excavation of the working face; Then, the frequency shift change sequence of optical fiber is converted into a time series. Finally, a combined model is built. The linear auto-correlation part of the frequency shift change sequence is predicted by ARMA model, and the nonlinear residual part is predicted by SVR model to jointly complete the prediction of the frequency shift change of optical fiber. The experimental results show that the combined model proposed in this paper is superior to the single auto-regressive moving average model in different data sets, and the ARMA-SVR combined model can effectively predict the change of optical fiber frequency shift and provide a new idea for the prediction of rock pressure in the mining process.
WITHDRAWN: A prediction model for a concentrating solar thermoelectric generator using artificial neural networks and extreme learning machines
Authors: Maduabuchi Chika , Al-Dahidi Sameer , Alnami Hashim , Alsuwian Turki
Published: August 2022

The current numerical simulation tools used to optimize the performance of concentrating solar thermoelectric generators are extremely time consuming, and consequently require expensive computational energies. Furthermore, they are incapable of considering the effects of diverse real-life operating conditions on the performance of the system. Additionally, they sometimes neglect temperature dependency in the thermoelectric semiconductors and base their studies on just unicouple thermoelectric cells to avoid the further complexity of the numerical computation. These factors limit the flexibility of optimization studies that can be conducted on solar thermoelectrics; hence, limiting the insights that can be drawn to design high performing solar thermoelectric generators. This work is the first of its kind to introduce artificial neural networks and extreme learning machines as a substitute to these numerical methods to accelerate and ease the design process of solar thermoelectric generators. The data generation process is conducted using a 3-dimensional numerical model developed in ANSYS numerical solver and the optimized parameters include the high-temperature material content, semiconductor height and area, concentrated solar irradiance, cooling film coefficient, wind speed, and ambient temperature – on the system performance. A full-scale customized thermoelectric module comprising 127 thermocouples is designed and integrated in an optical concentrator for solar power generation while considering temperature dependency in all thermoelectric materials. Results depict that the geometry and operating condition optimization improved the system power and efficiency by 42.02% and 82.23%, respectively. Furthermore, the artificial neural network had the highest regression of 95.82% with the least mean squared error of 2.71 \(\times\) 10− 5 in learning the numerical-generated data set while performing 389 and 203 times faster than the numerical method in forecasting the system power and efficiency, respectively. Finally, methods of manufacturing the optimized thermoelectric module using 3-dimensional printing are discussed.
Efficient purification and characterization of high-purity phycoerythrin 545 from Rhodomonas sp.
Authors: Pu Yang , Dong Shuo , Li Min , Dong Kai , Zhao Huawei , Tang Zhihong , Li Wenjun
Published: August 2022

Cryptomonad phycoerythrin 545 is an important type of phycobiliprotein in basic research and technological innovations. Herein, we report a minimalistic hydrophobic chromatography method for its purification. High purity was achieved, with a purity ratio (A545/A280) of 13.66 and a recovery ratio of 78.63%. Following SDS-PAGE, Coomassie Brilliant Blue staining and Zn2+-enhanced UV fluorescence autoradiography revealed three bands at 9 kDa, 10 kDa, and 20 kDa, corresponding to α1, α2 and β subunits. Multiple spectral characteristics were analysed to ensure that optical activity was consistent with that of the natural protein. Absorption and fluorescence spectroscopies of purified phycoerythrin 545 displayed a strong absorption peak at 545 nm and a shoulder peak at 564 nm, and a fluorescence emission peak of at 587 nm, which confirmed unchanged energy transfer properties, and structural and functional integrity was verified by circular dichroism spectroscopy. Compared with published purification methods, this new purification protocol replaces two-step ammonium sulphate fractionation, dialysis, and size exclusion chromatography with a single chromatography step, thereby reducing the cost of large-scale kilogram-level commercial production.
Impairment of electron transport chain and induction of apoptosis by chrysin nanoparticles targeting succinate-ubiquinone oxidoreductase in pancreatic and lung cancer cells
Authors: Ragab Eman M. , Gamal Doaa M El , Mohamed Tarek M. , Khamis Abeer A.
Published: August 2022

Background: Flavonoids may help ameliorate the incidence of the major causes of tumor-related mortality, such as pancreatic ductal adenocarcinoma (PDAC) and lung cancer, that are predicted to steadily increase between 2020 to 2030. Here we compared the effect of chrysin and chrysin nanoparticles (CCNPs) with 5-fluorouracil (5-FLU) on the activity and expression of mitochondrial complex II (CII) to induce apoptosis in pancreatic (PANC-1) and lung (A549) cancer cells.Methods: The binding affinity of chrysin to succinate dehydrogenase (SDH) was studied using molecular docking. CCNPs were synthesized and characterized, and the IC50 was evaluated in normal, PANC-1, and A549 cell lines using the MTT assay. The effect of chrysin and CCNPs on CΙΙ activity, superoxide dismutase activity, and mitochondria swelling were evaluated. Apoptosis was assessed using flow cytometry, and expression of the C and D subunits of SDH, sirtuin-3 (SIRT-3), and hypoxia-inducible factor (HIF-1α) was evaluated using RT-qPCR.Results: The IC50 of CII subunit C and D binding to chrysin was determined and used to evaluate the effectiveness of treatment on the activity of SDH with ubiquinone oxidoreductase. Enzyme activity was significantly decreased (chrysin < CCNPs < 5-FLU and CCNPs < chrysin < 5-FLU, respectively), which was confirmed by the significant decrease of expression of SDH C and D, SIRT-3, and HIF-1α mRNA (CCNPs < chrysin < 5-FLU). There was also a significant increase in the apoptotic effects (CCNPs > chrysin > 5-FLU) in both PANC-1 and A549 cells and a significant increase in mitochondria swelling (CCNPs < chrysin < 5-FLU and CCNPs > chrysin > 5-FLU, respectively) than that in non-cancerous cells.Conclusion: Treatment with CCNPs improved the effect of chrysin on succinate-ubiquinone oxidoreductase activity and expression and therefore has potential as a more efficient formulation than chemotherapy to prevent metastasis and angiogenesis by targeting HIF-1α in PDAC and lung cancer.
Comprehensive Analysis of Prognosis and Immune Function of CD70-CD27 Signaling Axis in Pan-Cancer
Authors: Kong Fanhua , Xiong Yan , Ye Qifa
Published: August 2022

The immune checkpoint molecule CD70 and its receptor CD27 constitute the signal transduction axis, which is abnormally expressed in many solid tumors and is crucial for T cell co-stimulation and immune escape. Tumor cells regulate the expression of CD27 by expressing CD70 in tumor microenvironment and promote immune escape.The discovery of the immunosuppressive effect of the CD70-CD27 signaling axis on tumor cells introduces a new anti-tumor immunotherapy - CD70. Although current research evidence suggests a link between CD70 and tumors, no pan-cancer analysis is available. Using the Cancer Genome Atlas and Gene Expression Omnibus datasets, we first explored the potential carcinogenic role of the CD70-CD27 signaling axis in human malignancies. CD70 expression is up-regulated in most cancers and has an obvious correlation with the prognosis of tumor patients. The expression of CD70 and CD27 is associated with the level of regulatory T cells (Tregs) infiltration. In addition, T cell receptor signaling pathways, PI3K-Akt, NF-κB, and TNF signaling pathways are also involved in CD70-mediated immune escape. CD70 mainly regulates tumor immune escape by regulating T cell-mediated tumor killing, while Tregs may be its main T cell subset. Our first pan-cancer study provides a relatively comprehensive understanding of the carcinogenic role of the CD70-CD27 signaling axis in different tumors.
Convolutional neural network quantification of Gleason pattern 4 and association with biochemical recurrence in intermediate grade prostate tumors
Authors: Chen Yalei , Loveless Ian , Nakai Tiffany , Newaz Rehnuma , Abdollah Firas , Rogers Craig , Hassan Oudai , Chitale Dhananjay , Arora Kanika , Williamson Sean , Gupta Nilesh , Rybicki Benjamin , Sadasivan Sudha , Levin Albert
Published: August 2022

Differential classification of prostate cancer (CaP) grade group (GG) 2 and 3 tumors remains challenging, likely due to the subjective quantification of percentage of Gleason pattern 4 (%GP4). Artificial intelligence assessment of %GP4 may improve its accuracy and reproducibility and provide information for prognosis prediction. To investigate this potential, a convolutional neural network (CNN) model was trained to objectively identify and quantify Gleason pattern (GP) 3 and 4 areas, estimate %GP4, and assess whether CNN-assessed %GP4 is associated with biochemical recurrence (BCR) risk in intermediate risk GG 2 and 3 tumors. The study was conducted in a radical prostatectomy cohort (1999–2012) of African American men from the Henry Ford Health System (Detroit, Michigan). A CNN model that could discriminate four tissue types (stroma, benign glands, GP3 glands, and GP4 glands) was developed using histopathologic images containing GG 1 (n = 45) and 4 (n = 20) tumor foci. The CNN model was applied to GG 2 (n = 153) and 3 (n = 62) for %GP4 estimation, and Cox proportional hazard modeling was used to assess the association of %GP4 and BCR, accounting for other clinicopathologic features including GG. The CNN model achieved an overall accuracy of 86% in distinguishing the four tissue types. Further, CNN-assessed %GP4 was significantly higher in GG 3 compared with GG 2 tumors (p = 7.2*10− 11). %GP4 was associated with an increased risk of BCR (adjusted HR = 1.09 per 10% increase in %GP4, p = 0.010) in GG 2 and 3 tumors. Within GG 2 tumors specifically, %GP4 was more strongly associated with BCR (adjusted HR = 1.12, p = 0.006). Our findings demonstrate the feasibility of CNN-assessed %GP4 estimation, which is associated with BCR risk. This objective approach could be added to the standard pathological assessment for patients with GG 2 and 3 tumors and act as a surrogate for specialist genitourinary pathologist evaluation when such consultation is not available.
On real center singularities of complex vector fields on surfaces
Authors: SCARDUA BRUNO , Leon Victor
Published: August 2022

One of the various versions of the classical Lyapunov-Poincaré center theorem states that a nondegenerate real analytic center type planar vector field singularity admits an analytic first integral. In a more proof of this result, R. Moussu establishes important connection between this result and the theory of singularities of holomorphic foliations (\cite{moussu}). In this paper we consider generalizations for two main frameworks: (i) planar real analytic vector fields with ``many'' periodic orbits near the singularity and (ii) germs of holomorphic foliations having a suitable singularity in dimension two.
In this paper we prove versions of Poincar\'e-Lyapunov center theorem, including for the case of holomorphic vector fields. We also give some applications, hinting that there is much more to be explored in this framework.
Re-thinking on land degradation and its impacts on livelihoods of the farmers in Kanungu District, Uganda
Authors: Turyasingura Benson , Ayiga Natal , Benzougagh Brahim
Published: August 2022

Land degradation has made it difficult for people to make a living in Uganda, one of the world's poorest nations. Land degradation in Uganda poses a severe danger to rural populations' ability to support themselves. The primary natural resource used by humans for economic, social, infrastructure, and other human endeavors is land. Land resources are so crucial in determining rural livelihoods, and the absence of sustainable land management techniques results in land degradation. This study looked at the Kanungu district in southwestern Uganda in order to examine the relationship between land degradation and rural populations' ability to support themselves. Additionally, the factors that affect households in the study area's ability to diversify their sources of income are covered. The objective of this paper is to provide an in-depth understanding of the causes of land degradation and its impacts on livelihoods, as well as possible solutions to the impacts of land degradation in Kanungu district. To achieve these objectives, the study used a cross-sectional research approach, where the information gathered reflects the state of affairs at a specific time, making it possible to gather insightful information quickly. Since a cross-sectional survey allows for the gathering of data using a range of techniques, a mixed method was used in this study, combining quantitative and qualitative techniques. As a result, the study findings proved that there was a significant positive relationship between the effects of land degradation and the livelihoods of farmers (p 0.01, r =.530**) in Kanungu District, which suggests that adoption of new seed varieties which can withstand harsh climatic conditions, strengthening agricultural reforms, and agroforestry would improve the livelihoods of local farmers to improve their savings and production of quality crop products. Therefore, the alternative hypothesis was therefore accepted and it was concluded that "There is a significant relationship between land degradation and the livelihoods of farmers in Kanungu District." Hence, it can be concluded that land degradation significantly affects the livelihoods of farmers. It is also concluded that a majority of the participants agree that deforestation causes land degradation.
The impact of key indicators on the overall performance of Saudi Arabian telecommunication companies
Authors: Aldoghan Mohammed , Jaber Aburumman Omar , Omar Khatijah , Abdulhameed Abdulwahid Nadia
Published: August 2022

Performance management helps organizations to ensure that they are on the right path. Thus, this requires increasing the ability of organizations to understand their own key indicators to manage and measure their performance. The purpose of this study is to determine the key performance indicators used in Saudi Arabian telecommunication companies. Moreover, it examines whether these indicators impact the overall performance of Saudi Arabian telecommunication companies. This study adopted a quantitative method based on a survey questionnaire. Participants were reached through human resources officers in the telecommunication companies. Questionnaires were distributed to 247 employees at middle and top management levels in Saudi Arabian telecommunication companies using a convenience sampling technique. However, 212 responses were returned completely filled with a response rate of 85.8%. This study used statistical software of SPSS and SmartPLS for data analysis. The results revealed that customer satisfaction, delivery reliability, learning and growth, employee satisfaction, cost, financial performance, flexibility, and quality are the key indicators used in Saudi Arabian telecommunication companies to measure performance. The results also revealed that customer satisfaction, delivery reliability, learning and growth, employee satisfaction, cost, financial performance, flexibility, and quality have an impact on the overall performance of Saudi Arabian telecommunication companies. These indicators can be used to determine the state of organizations, help measure the implementation of strategies, evaluate the organization’s current performance, design strategies for improvement, and evaluate organization’s departments and employees.
AcknowledgmentThis paper was supported by the Deanship of Scientific Research, Vice Presidency for Graduate Studies and Scientific Research, King Faisal University, Saudi Arabia [GRANT348].
COVİD-19 PANDEMİ SÜRECİNDE ENGELLİ ÇOCUKLARIN FONKSİYONELLİĞİ İLE EBEVEYNLERİN ETKİLENİMLERİ ARASINDAKİ İLİŞKİ
Authors: ŞEN Güliz , AYTAR Aydan
Published: August 2022

Amaç: Bu çalışmanın amacı Covid-19 pandemi sürecinde engelli çocukların fonksiyonelliği ile ebeveynlerin etkilenimleri arasındaki ilişkiyi araştırmaktı.

Yöntem: Çalışmaya 4-12 yaş arasında 84 engelli çocuk ve 84 anne olmak üzere toplam 168 kişi dahil edildi. Engelli çocuklar için Pediatrik Özürlülük Değerlendirmesi Envanteri (PÖDE) ve Kaba Motor Fonksiyon Sınıflandırma Sistemi (KMFSS) kullanıldı. Annelere Zarit Bakım Verme Yükü Ölçeği (ZBVYÖ), Yorgunluk Şiddet Ölçeği (YŞÖ) ve kas-iskelet sistemi rahatsızlıklarını sorgulamak için İskandinav Kas İskelet Sistemi Sorgusu (İKİSS) uygulandı.

Sonuçlar: Bakım yükü puanı ile PÖDE toplam puanı, kendine bakım ve mobilite puanları arasında herhangi bir ilişki görülmedi (p>0,05). Bakım yükü puanı ile sosyal fonksiyon puanı arasında ise orta düzeyde negatif yönde (r=-0,306; p0,05). Bakım yükü puanı ile yorgunluk şiddet puanı arasında ilişki tespit edilmedi (p>0,05). Ebeveynlerin son 12 ay süresince sadece bel bölgesindeki ağrı olağan işlerini yapmayı engelledi. Son 12 ay süresince kas iskelet sistemi ağrısından yakınan ebeveynlerde en çok ağrıyan vücut bölümleri bel, boyun, omuz, sırt, diz bölgesinde olduğu tespit edildi.

Tartışma: Covid-19 pandemi sürecinde engelli çocukların fonksiyonelliği ile ebeveynlerinin etkilenimleri arasında bir ilişki olmadığı bulundu.
La lógica inimputable del misticismo burocrático
Authors:   Universidad Católica de la Santísima Concepción, Molteni Agostino , Araya Pamela ,   Universidad de Chile
Published: August 2022

La filosofía ha reflexionado a menudo acerca de la naturaleza de la burocracia, de su lógica y método, de sus consecuencias. En este artículo se quiere presentar cómo la inimputable y, por ello, irrazonable lógica burocrática se fundamenta en una psicopatológica religiosa, “mística”. Para mostrar esta temática nos servimos de lo que han escrito Max Weber en su Economía y sociedad y Hannah Arendt en Los orígenes del totalitarismo, ya que nos parecen los autores que más han comprendido y señalado el fundamento místico-religioso de la lógica burocrática. Por ello, en un primer punto mostraremos en qué consiste según estos autores la lógica del pensamiento burocrático y, en un segundo punto, señalaremos el fundamento patológico-religioso de esta lógica.
Contamination and antimicrobial resistance profile of Escherichia coli in chicken carcasses from public markets in Maranhão
Authors: Tavares Gilcimara da Silva , Brito Daniela Aguiar Penha , Sousa Gracielle Lopes Almeida , Cruz Alexsandra Iarlen Cabral , Bogéa Juliana Sousa , Passos Aline Catarina Santos dos
Published: August 2022

Contamination of chicken meat sold in public markets is a public health concern. The objective of this study was to identify contamination and evaluate the antimicrobial resistance profile of Escherichia coli in chicken carcasses from public markets in the North Mesoregion of Maranhão. A total of 160 freshly slaughtered chicken carcasses were collected in 16 markets in six municipalities in the microregions of Itapecuru-Mirim and São Luís. The samples were analyzed for the presence of E. coli using counting thermotolerant coliforms and classified according to the ANVISA microbiological standard. Of all the samples, 134 (83.75%) were considered unacceptable for consumption, according to Brazilian health legislation. Bacteria were isolated from the positive samples, and 50 isolates were tested for susceptibility to 15 antimicrobial principles using the disc diffusion method. The results confirm the presence of E. coli, with counts ranging from 101 to 108 NMP/g. The isolates showed resistance to neomycin (49/50, 98%), streptomycin (48/50, 96%), sulfonamides (47/50, 94%), nitrofurantoin (45/50, 90%), cefazolin (43/50, 86%), and tetracycline (43/50, 86%). No antibiotic was effective against the isolates, which were resistant to more than 3 antimicrobial classes considered resistant to multiple drugs (MDR). Therefore, chicken meat sold in public markets in Maranhão presents unsatisfactory conditions for consumption and risk of transmission of E. coli with an MDR profile.
Kebutuhan guru dan orang tua dalam layanan pendidikan bagi anak dengan hambatan majemuk di masa pandemi covid-19
Authors: Zakiah Zykra , Hermanto Hermanto
Published: August 2022

Tujuan dari penelitian ini adalah untuk mencari tahu akan kebutuhan guru dan orang tua dalam layanan pendidikan untuk anak dengan hambatan majemuk di masa covid-19. Jenis penelitian yang digunakan dalam penelitian ini adalah kualitatif, dengan pendekatan deskriptif, Teknik pengumpulan data pada penelitian ini menggunakan observasi, wawancara, dan Google form. Hasil penelitian menunjukkan bahwa ada 2 kebutuhan yang mendasar yang diperlukan oleh guru dan orang tua anak dengan hambatan majemuk dalam layanan pendidikan yang di lakukan pada masa covid-19, diantarinya dibutuhkannya (1) Home Visit, guru mendatangi rumah anak dengan hambatan majemuk, tentunya layanan ini juga harus di buat aturan dan disepakati oleh kedua belah pihak, antara guru serta orang tua dan (2) Perlu dilakukannya adaptif kurikulum untuk mengatur strategi dan perencanaan pembelajaran baik secara daring ataupun luring.
PENGEMBANGAN SISTEM KOMUNIKASI AUGMENTATIF DAN ALTERNATIF PADA NOTASI DALAM PEMBELAJARAN MUSIK ANAK AUTIS
Authors: Erlani Lalan , Bachtiar Ishak Gerard , Taboer Arif
Published: August 2022

Program layanan pembelajaran musik bagi anak autis dalam implementasinya masih banyak kendala dalam komunikasi antara guru dan siswa. Penelitian menunjukkan sebesar 50% anak dengan spektrum autistik tidak akan mengembangkan kemampuan bicara yang memadai untuk memenuhi kebutuhan komunikasinya. Sehingga alat komunikasi seperti Augmentative and Alternative Communication (AAC) menjadi diperlukan. Penelitian ini bertujuan menemukan penggunaan yang tepat  Augmentative and Alternative Communication (AAC) pada notasi yang tepat dalam pembelajaran musik bagi anak autis yaitu bagaimana pengembangan sistem AAC dalam pembelajaran musik serta dampaknya pada kemampuan musik bagi anak autis. Mixed Method Research sebagai pendekatan dengan kualitatif deskriptif untuk mengeksplore data dalam menemukan ketepatan sistem AAC dan Single Subject Research untuk menganalisis perubahan kemampuan subjek. Tejuannya (1) Penggunaan AAC untuk pengembangan pada notasi musik anak autis adalah pengembangan kartu AAC berbasis asesmen yang dikelompokan berdasarkan materi, (2) Analisis dampak pengembangan yang berdampak signifikan terhadap penggunaan AAC pada notasi pembelajaran musik bagi anak autis yang ditunjukan pada perubahan kemampuan musik materi notasi, dinamika dan tempo dengan mendukung fungsi komunikasi pada pembelajaran. Penelitian ini dapat menjadi pertimbangan mendasar dalam pengembangan sistem AAC selanjutnya
In Vitro inhibition of plasmodium falciparum by substances isolated from antimalarial plants.
Authors: Bhat Mushtaq Ahmad , Khan Fairooz Ahmad , H.C.Kataria Dr.
Published: August 2022

In the present study, a neosergeolide, isolated from the roots of Jurinea dolomiaea Boiss (Asteracae), the indole alkaloid aspidocarpine, isolated from the bark of Alstonia scholaris (Apocynaceae) and 4-nerolidylcatechol, isolated from the seed of Datura stramonium Linn. (Solinaceae), all presented significant in vitro inhibition (more active than quinine and chloroquine) of the multi-drug resistant K1 strain of Plasmodium falciparum. Neosergeolide presented activity in the nanomolar range. These compounds are good for pre-clinical tests as novel lead structures with the aim of finding new antimalarial prototypes and provide support to the traditional use of the plants.
Environmental Policy of Solid Urban Waste and the Socio-Environmental Impacts in Baturité, Ceará, Brazil
Authors: Xavier Antonio Roberto , da Silva Veridiana Torres , Kanikadan Andrea Yumi Sugishita , Amorim Aiala Vieira , Pinto Olienaide Ribeiro de Oliveira , Tavares Carlos Mendes , Cysne Maria do Rosário de Fátima Portela , Tavares Rosalina semedo de Andrade , Caetano Luís Miguel Dias , Lima Liliane Araújo , Muniz Karla Renata de Aguiar , Fonseca Michella Rita Santos , Lima Maria Vandia Guedes , Queiroz Juliana Fernandes da Silva , Aquino Antonio Leonardo Moreira de , Oliveira Júlio César Lopes de , Santana José Rogério
Published: August 2022

The research had as its primary objective to understand, from the socio-environmental perspective, the limits, and possibilities of the dynamics of solid urban waste treatment in the municipality. Methodologically, this research study is an exploratory case study, of a basic nature with a qualitative approach. For data collection the techniques of direct observation and non-directive interview were applied to collectors/ dwellers of the municipal dump of Baturité-CE. As for the analysis techniques, content analysis and socio-historical contextual narrative discourse were used. As conclusive results, the study found that the collectors / residents live in a situation of socio-economic and environmental vulnerability, without having a collective organization to support them, including the absence of municipal government in relation to support these professional collectors of urban solid waste in general and in the locus of the research, specifically.
Política de gestión documental para la Universidad Central “Marta Abreu” de Las Villas
Authors: Díaz Jiménez Asleni , Mena Mujica Mayra Marta
Published: August 2022

La creación de una Política de Gestión Documental en universidades fortalece sus procesos informativo-documentales. El objetivo de la investigación es diseñar la Política de Gestión Documental para la Universidad Central “Marta Abreu” de Las Villas. Dicho centro se encuentra en la ciudad de Santa Clara, siendo la casa de altos estudios más importante del centro de Cuba. Para el diseño del instrumento se utilizó como método fundamental el análisis documental y su técnica de revisión de documentos. Se presenta la Política a partir de la identificación y la descripción de los componentes de la misma, entre los cuales destacan: Glosario de términos, Preámbulo, Propósito, Declaración de Política, Alcance, Marco regulatorio y reglamentario, Sistemas de Gestión Documental, Responsabilidades, Relación con otras políticas, y Vigencia. La propuesta de la Política se encuentra en consonancia con los ejemplos de buenas prácticas establecidas a nivel internacional en universidades y con el análisis de las directrices normativas vinculadas a dicho proceso.
Un enfoque de Gobierno Abierto para las bibliotecas: colecciones y servicios
Authors: Voutssás Lara Jennifer Alejandra
Published: August 2022

Con la Ley Federal de Acceso a la Información Pública Gubernamental (LFTAIPG) de 2002 comenzaron en México los mecanismos formales para fomentar el acceso a la información pública y la transparencia. La propuesta internacional de Gobierno Abierto pretende, desde 2009, crear mecanismos de acceso a la información y rendición de cuentas aún más abiertos por medio de tres pilares: transparencia, colaboración y participación ciudadana. Hasta la fecha, no existen propuestas concretas de cómo integrar a las bibliotecas en la colaboración con los esfuerzos para fomentar la formación y la transformación ciudadana. Este texto integra elementos y enfoques de disciplinas socio-políticas a los principios y estructuras de las bibliotecas y archivos para hacer un análisis y un resumen de los elementos que pueden ser utilizados en la conceptualización integral de colecciones bibliotecarias, fondos archivísticos y sus respectivos servicios bajo principios de Gobierno Abierto, con miras a que estas instituciones colaboren de forma más proactiva en la formación y participación ciudadana, perfeccionando el acceso a la información.
Healthcare Chatbot using Artificial Intelligence
Authors: Patil Anuj
Published: August 2022

Abstract: Healthcare as one of the vital spheres of human life is badly falling behind technological progress. While e-commerce, hospitality, and the food industry are advanced and augmented with various technological solutions, healthcare still sticks to the traditional way of doing things. Why can you order a pizza in ten seconds but must wait for an appointment with a doctor for days and weeks? How can you make sure that urgent medical help is indeed urgent? Why finding a credible answer to an important question about your health is so annoyingly difficult? I am also deeply concerned about the lack of attention that the healthcare industry receives. And the first and easiest solution I can offer to change it is to implement chatbot technology in healthcare. Healthcare chatbots will never substitute doctors. But they provide plenty of opportunities to facilitate their job or to improve their performance. The medical chat-bots functioning depends on Natural Language Processing which helps users to submit their problems about their health. The user can ask any personal query related to health care through the chatbot without being out physically available to the hospital. By using Google API for voice-text and text-voice conversion query is sent to the chatbot and gets a related answer and displays the answer on the android app. The system’s major concern behind developing this web-based platform is analyzing customers’ sentiments.
Arabic Language Representation in Naming Children: A Case of Shift Naming of Melayu Children
Authors: Safitri Novi Ulfa , Fauzi Moh. Fery
Published: August 2022

The phenomenon of the shift in the naming of Melayu children, which used to use naming from the Arabic language, has recently shifted in Palembang, South Sumatera, Indonesia. It has an effect on how parents perceive the Arabic language. This study aimed to 1) analyze the trend of naming Melayu children in Palembang, 2) analyze the influence of the Arabic language on parents in naming Melayu children, and 3) analyze the naming transformation of Melayu children. The methodology used by researchers was a qualitative method using a socio-onomastic approach. The population was taken from students of STIKES Siti Khadijah Palembang and students of MTs.N 2 Palembang. Data were analyzed using Strauss and Corbin’s grounded theory model. The results showed: 1) there were three trends in naming Melayu children: a) hereditary (using bebangso); b) Arabic language; and c) modern trends. 2) Arabic language influences parents in naming children in various ways: a) on community construction; b) resistance; and c) the influence of public figures. 3) the transformations of the naming of Melayu children in Palembang were: a) naming transformation of children from the descent, Arabic language, and modern to westernized; b) shift in the referential system; and c) the cause of this transformation is a modernization factor that caused parents to transform in naming their children from Arabic language names transformed into modern names. Currently, naming children using Arabic language names is less represented rather than in the early 2000s. This transformation gives birth to a global society, not a local community, which is marked by the names of modern and westernized children.
Development of the Arabic Grammar (Nahwu) Textbook Al-Ajurumiyyah Al-Qur'aniyyah based on the Scaffolding-Structure
Authors: Muzdalifah Zahrotul , Khasairi Moh. , Kholisin Kholisin
Published: August 2022

This study was conducted to meet the needs of Nahwu textbooks in Islamic boarding schools based on the scaffolding-structure based on the Al-Ajurumiyyah Al-Qur’aniyyah book by adhering to the applicable Nahwu principle. The research method used is ADDIE model development research This textbook has innovations in the form of a comprehensive concept map, the application of scaffolding theory with sentence patterns from examples of verses of the Qur’an, and a quick response code containing interesting learning content. The textbook is very valid and can be implemented after going through the validation test with the presentation of the results of material validation 95.45%, media validation 89.18%, and validation of learning 95.92%. The effectiveness test with paired t-test shows that the book being developed has a significant effect on student learning.
PENGETAHUAN DAN SIKAP MASYARAKAT TERHADAP KONSERVASI PENYU DAN EKOWISATA DI DESA HADIWARNO KABUPATEN PACITAN SEBAGAI SUMBER BELAJAR BIOLOGI
Authors: Kurniarum Martina , Prihanta Wahyu , Wahyuni Sri
Published: August 2022

Pengetahuan adalah segala informasi yang diserap oleh manusia dari berbagai sumber baik secara langsung maupun tak langsung. Sikap adalah kerangka tindakan yang akan dilakukan oleh manusia setelah mendapatkan respon dari lingkungannya. Pengetahuan dan sikap masyarakat dalam upaya konservasi dan ekowisata yang telah dilakukan di Desa Hadiwarno Kabupaten Pacitan perlu digali sebagai evaluasi dan pertimbangan untuk perkembangan ke depannya, sehingga dengan adanya penelitian ini diharapkan dapat bermanfaat bagi masyarakat serta pihak-pihak terkait untuk meninjau kedaan nyata yang tergambar dalam hasil penelitian. Penelitian ini bertujuan untuk menggambarkan pengetahuan dan sikap masyarakat terhadap konservasi penyu dan ekowisata, perbedaan pengetahuan dan sikap antar kelompok masyarakat, hubungan antara pengetahuan dan sikap masyarakat terhadap konservasi penyu dan ekowisata serta menghasilkan sumber belajar biologi. Jenis penelitian yang digunakan adalah penelitian dekriptif. Tempat dan waktu penelitian dilaksanakan di Desa Hadiwarno Kabupaten Pacitan yang berlangsung pada tanggal 28 April – 4 Mei 2014. Metode pengumpulan data yang digunakan adalah angket. Analisa data penelitian menggunakan analisis varians satu jalan dan uji lanjut post hoc test serta analisis hubungan product moment. Sebagian besar tingkat pengetahuan masyarakat pada ketiga kelompok masyarakat tergolong pada taraf cukup baik, baik, dan sangat baik terhadap konservasi penyu dan ekowisata. Perbedaan pengetahuan antara KMKPW (Kelompok Masyarakat Konservasi Penyu untuk Wisata), Kelompok Pelajar dan Kelompok Masyarakat Umum memiliki perbedaan yang signifikan (p<0,05). Sebagian besar tingkat sikap masyarakat pada ketiga kelompok masyarakat tergolong pada taraf baik dan sangat baik terhadap konservasi penyu dan ekowisata. Perbedaan sikap KMKPW (Kelompok Masyarakat Konservasi Penyu untuk Wisata), Kelompok Pelajar dan Kelompok Masyarakat Umum memiliki perbedaan yang tidak signifikan (p>0,05). Hasil penelitian menunjukkan ada hubungan antara pengetahuan dan sikap masyarakat terhadap konservasi penyu dan ekowisata.Kata Kunci: Pengetahuan, Sikap, Konservasi Penyu, Ekowisata
PEMANFAATAN PTERIDOPHYTA KAWASAN HUTAN PACET TAMAN HUTAN RAYA (TAHURA) RADEN SOERJO KECAMATAN PACET KABUPATEN MOJOKERTO SEBAGAI SUMBER BELAJAR BIOLOGI SMA
Authors: Lusiana Neni , Prihanta Wahyu , Rahardjanto Abdulkadir
Published: August 2022

ABSTRAKPenelitian ini bertujuan untuk mengetahui Pteridophyta apa saja yang terdapat di kawasan Hutan Pacet Taman Hutan Raya Raden Soerjo Kecamatan Pacet Kabupaten Mojokerto dan bagaimana klasifikasinya, serta untuk mengetahui implementasi hasil penelitian Pteridophyta agar dapat digunakan sebagai sumber belajar biologi SMA. Jenis penelitian yang digunakan adalah jenis penelitian deskriptif. Penelitian di laksanakan di dua tempat, pengambilan sampel Pteridophyta dilaksanakan di kawasan hutan Pacet Taman Hutan Raya Raden Soerjo Kecamatan Pacet Kabupaten Mojokerto pada koordinat S 07o44’00” – S 07o42’10” dan E 112o31’30” – E 112o32’30”. Pengambilan sampel tumbuhan paku yang terestrial maupun epifit pada penelitian ini menggunakan metode jelajah (cruise methods). Sedangkan pemanfaatan hasil penelitian Pteridophyta di kawasan ini yaitu berupa modul yang divalidasi dilakukan oleh guru biologi di SMAN 2 Batu. Berdasarkan hasil penelitian ditemukan sebanyak 57 jenis Pteridophyta yang termasuk dalam 3 kelas. Ditemukan 3 jenis dari kelas Lycopodiinae, 1 jenis dari kelas Equisetinae, dan 53 jenis dari kelas Filicinae. Penggunaan Pteridophyta untuk sumber belajar di sekolah dalam bentuk modul dengan pemberian soal-soal dan pemberian tugas proyek membuat herbarium.Kata Kunci: Hutan Pacet TAHURA Raden Soerjo, Pteridophyta, sumber belajar biologi SMA
KEBIASAAN MAKAN PAGI PADA ANAK USIA SD DAN HUBUNGANNYA DENGAN TINGKAT KESEHATAN DAN PRESTASI BELAJAR
Authors: Sukiniarti Sukiniarti
Published: August 2022

Makanan sehari-hari yang dipilih dengan baik akan memberikan semua zat yang diperlukan oleh tubuh untuk hidup sehat. Khususnya untuk anak usia sekolah dasar yang dikategorikan masih dalam taraf perkembangan dan pertumbuhan, maka makan pagi sangat diperlukan untuk menunjang aktivitasnya. R.E.Kleinman (2013), mengatakan bahwa anak yang tidak sarapan pagi cenderung tidak konsentrasi dalam belajar. Tujuan penelitian ini untuk mengidentifikasi: (1) seberapa banyak  anak usia SD membiasakan makan  pagi sebelum berangkat sekolah. (2) penyebab anak usia SD tidak makan pagi sebelum berangkat  sekolah. (3)  hubungan makan pagi dengan tingkat kesehatan dan prestasi belajar  anak usia SD. Metode yang digunakan metode kuantitatif. Informasi pengambilan data digali melalui survai, dokumentasi dan wawancara. Hasil penelitian menunjukkan:(1) 89,66% anak setiap pagi selalu makan pagi sebelum berangkat  sekolah. (2) 43,11% anak usia SD kelas 2 tidak makan pagi sebelum berangkat sekolah dikarenakan bangun kesiangan. (3) Hubungan antara makan  pagi dengan tingkat kesehatan dan prestasi belajar anak SD kelas 2 di wilayah Kelurahan Pondok Benda tidak begitu erat, dikarenakan adanya  faktor genetik.