bluuebunny/crossref_metadata_2025 huggingface dataset:
Nonsurgical eyelid ptosis: topical treatment with Endolift® direct optical energy
Authors: D. Kaliterna  , R. Sadoughifar R. Sadoughifar , D. Kaliterna D. Kaliterna , R.J. Llergo Valdez R.J. Llergo Valdez , M. Kamalska M. Kamalska , A. Abdelmaksoud A. Abdelmaksoud , B. Türsen B. Türsen , Kaliterna Dinko
Published: February 2023

This study was designed to evaluate the efficiency of Endolift®, a novel minimally invasive outpatient laser procedure, for the nonsurgical treatment of eyelid ptosis. Thirty patients aged 30 to 55, 15 women and 15 men, were enrolled on this study. All patients had skin ptosis of the upper eyelids and the eyebrow area and dropping of the lateral part of the eyebrow. Patients have undergone a single treatment under micro drops of local anaesthesia. Treatment was performed using the Endolift® procedure, consisting of the device Eufoton® LASEmaR® 1500. This device uses a 1470 nm wavelength laser lead by micro-optical fibres of different calibres directly inside the skin. Twenty-four reported optimal results, 4 very good and 2 moderate. The first results were visible after 5 to 14 days and improved over time, and the average downtime was between 2 and 3 days due to the swelling. No other side effects were observed. These data confirm that Endolift® is a safe and effective procedure for the nonsurgical treatment of eyelid ptosis representing a real alternative to surgery.
Természetes nitrátforrás hatásának vizsgálata hagyományos pácolású termék esetében mesterséges adalékanyag csökkentése céljából
Authors: Visy Anna , Hidas Karina Ilona , Barkó Annamária , Horváth-Mezőfi Zsuzsanna , Jónás Gábor , Friedrich László
Published: February 2023

Az egészségesebb, fogyasztók által elfogadott élelmiszerek iránti növekvő kereslet kielégítése érdekében számos húsfeldolgozó kezdett el növényi alapú pácolóanyagok használatával kísérletezni. Ez alapján az elvégzett kutatási munkánk célja a mesterséges nitrit helyettesítése hagyományos pácolású, hosszú érlelési idejű termékek előállítása során természetes eredetű nitrátforrásokkal, és az így készített termék minőségi jellemzőinek vizsgálata volt. Természetes nitrátforrásként a zeller alkalmazhatóságát vizsgáltuk. Kísérleti munkánkban zellergyökérporral, zellergyökérpor és nitrátbontó mikroba (Staphylococcus carnosus) kombinációjával készítettünk nyers, pácolt, csont nélküli sertéskarajt. Kontroll mintaként a hagyományosan pácolt hús szolgált. A minták nedves pácolását minden esetben 7 napig, 10 m/m%-os NaCl-oldatban végeztük. A nyers hús tömegére számított 0,5% mennyiségű zellerport és a Staphylococcus carnosus (106 TKE/cm3) szuszpenziót a pácléhez adagoltuk. A pácolás során nyomon követtük a pácérettséget mutató pácolt szín kialakulását, a minták sótartalmát, vízaktivitását, valamint nedvességtartalmát. Ezenkívül célunk volt még vizsgálni a termék nitrit- és nitráttartalmának alakulását, valamint a Staphylococcus-szám változását. A különböző adalékanyagokkal pácolt termékek esetén az L*, a* és b* színtényezők közül csak az a* (vörös)-értékek esetében volt szignifikáns különbség a termékek között. A nátrium-nitrit felhasználásával készített termék a*-értéke mind a pácolás, mind az érlelés során szignifikánsan nagyobb, vagyis a hús vörösebb volt, mint a zellerporral, valamint a zellerpor és Staphylococcus carnosus kombinációjával pácolt mintáké. A különbség az emberi szem számára is jól látható volt. A nátrium-nitrittel készített termékek nitrittartalma a pácolás és érlelés során 68 mg/kg-ról 34 mg/kg-ra csökkent. A zellerporral készített termékek esetében a nitráttartalom az érlelés végére 37 mg/kg és 43 mg/kg volt, a nitrátból redukálódott nitrittartalom pedig 13 mg/kg és 25 mg/kg. A kísérlet során alkalmazott zellerpor-mennyiségből kevesebb nitrit keletkezett, mint a nátrium-nitrittel készített termékekben.
Húsromlás nyomon követésének fogyasztói érzékszervi lehetőségei
Authors: Gulyás Pálma , Bálint Melinda , Kókai Zoltán
Published: February 2023

Az élelmiszer-biztonság és az élelmiszer-pazarlás kérdése jelentős társadalmi probléma. A háztartásokban jelentkező élelmiszer-tárolási és -kezelési gyakorlatokból adódóan olyan kockázatok jelentkezhetnek, melyekre a törvényi szabályozásnak nincs ráhatása. Munkánkban két érzékszervi módszert vetettünk össze darált sertéscombminták hűtőszekrényben tárolásának követésére. A kategóriaskála alkalmazásával igen hamar azonosítható volt a romlás elindulása. A strukturálatlan skála esetében a kisebb különbségek inkább a romlási folyamatok későbbi szakaszában voltak kimutathatók. A módszereket hatékonyan egészítette ki egy olyan kifejezéslista alkalmazása, amiamelyből a bírálók kijelöl-hették azokat a kifejezéseket, amelyek az adott minta érzékszervi leírására alkalmasak voltak.
HHP-kezelés hatása mangalicahúsok és -szalonnák minőségi jellemzőire
Authors: Majzinger Koppány László , Hidas Karina Ilona , Visy Anna , Barkó Annamária , Horváth-Mezőfi Zsuzsanna , Friedrich László , Jónás Gábor
Published: February 2023

A kísérlet során egyértelműen megállapítást nyert, hogy komoly potenciál rejlik a húsok és a szalonnák nagy hidrosztatikai nyomás alkalmazásával történő tartósításában. Kijelenthető, hogy a módszer önmagában más, hagyományos eljárásokkal nem kombinálva is képes a megfelelő konzerváló hatás kifejtésére. A fizikai tulajdonságok vizsgálatakor megállapítottuk, hogy a szín esetében szabad szemmel is tisztán látható változás következett be a kezelés hatására. A nyomás növelésével a világossági tényező értéke is nőtt, azaz kifakult a hús. A textúrában bekövetkezett módosulás és az alkalmazott nyomás közötti korreláció viszont már nem volt ennyire egyértelmű. 200 MPa tenderizáló hatást fejtett ki a húsra, 400, valamint 600 MPa az állomány keményedését eredményezte. A sütés során fellépő veszteséget fokozta az eljárás, de a nyomás nagysága nem befolyásolta a veszteség mértékét. A mikrobiológiai eredmények kiértékelésekor ezzel ellentétes következtetést kaptunk, ugyanis a 600 Mpa-os nyomás nagyságrendekkel nagyobb csírapusztító hatással bírt, mint a 200 MPa-os.
DEVELOPING A PROCESS TO EVALUATE THE EFFECTIVENESS OF INFRARED CAMOUFLAGE UNIFORMS IN JUNGLE-MOUNTAINOUS TERRAIN
Authors: Vu Duc Hieu
Published: February 2023

Developing methods to evaluate the effectiveness of camouflage against thermal reconnaissance devices reliably and close to reality is an urgent requirement today. Therefore, applying camouflage solutions against thermal reconnaissance equipment has been developing rapidly in many countries. However, to reach the target, it is essential to develop a process and method to evaluate the properties of camouflage materials and means in the laboratory, simulate targets in the virtual environment, and asset the effectiveness of camouflage directly at the scene. In Vietnam, research in the field still needs more information and has only recently been implemented. To deal with the target above, the research team conducted studies to develop and evaluate the effectiveness of thermal camouflage. This article focuses on developing a complete procedure for the field method to evaluate the effectiveness of thermal camouflage. The result can be applied to evaluate and select the thermal camouflage material and facilities in jungle - mountainous terrain.Thermal imaging
Adicción a redes sociales y su relación con la autoestima en estudiantes universitarios
Authors: Collantes K. Doménica , Tobar Andrea
Published: February 2023

Las redes sociales son espacios virtuales creados con la finalidad de mejorar la comunicación entre seres humanos debido a la velocidad en la que la información puede llegar en distintos momentos y a diversos países, pese a que tiene muchas ventajas el uso desmedido o descontrolado de estos espacios tecnológicos trae consigo una serie de afectaciones a nivel psicológico ya que al estar dedicando mucho tiempo a las redes sociales el usuario comienza a pensar que otras personas tienen la vida que ellos desean y se sienten insuficientes consigo mismo viendo afectada así su autoestima; es así la propia percepción sea negativa o positiva del individuo. El estudio tiene como objetivo establecer la relación entre adicción a redes sociales y autoestima en los estudiantes universitarios, para ello se utilizó una muestra de 280 participantes, 25.3% son hombres y 74.7% son mujeres entre los 17 a los 25 años de una institución superior pública, a quienes se les aplica la Escala de Autoestima de Rossenberg y el Social Media Addiction Scale. Los resultados muestran una relación negativa entre los niveles de adicción a redes sociales y sus dimensiones: ocupación (rho= -0.281), modificación del estado de ánimo (rho= -0.402), recaída (rho= -0.310) y conflicto (rho= -0.386) con los niveles de autoestima, además de que no se encuentra una diferencia significativa en cuanto a la comparación del sexo en mayor o menor nivel de adicción (p> 0.05). Finalmente se determina mientras menor nivel de autoestima presenta los universitarios mayor adicción a redes sociales.
Estimating Geophysical Parameters Using Petrophysical Algorithm to Enhance Hydrocarbon Recovery in Lokaka Field, Niger Delta, Nigeria
Authors: Adepehin Damilare , Odudu Abimbola Isaac , Adelayi Adediran Oluwaseun , Adikwu Stephen Onum , Ahmad Muhammad Sanni , Alfred Daniel Owoicho
Published: February 2023

Adoption of Enhanced Oil Recovery (EOR) to boost the hydrocarbon saturation (Sh) of reservoirs has caught the interests of many researchers in Geosciences. Evidence from literature shows that both primary and secondary recovery methods have failed to account for about 60% hydrocarbon (HC) that is trapped in the reservoirs and getting to discover large productive new fields has become a herculean task. This study identified the fluid nature and boundaries of reservoirs using some relevant geophysical (petrophysical) parameters and reservoir rocks physical features such as shale volume (Vsh), permeability (K), water and hydrocarbon saturation (Sw& Sh). Petrophysical data were sourced from the data bank of the Department of Geology, Obafemi Awolowo University, Ile-Ife, Nigeria. Analysis of data was done using the PETREL 2010 and OpendTect 4.6.0 versions for quality checking, delineation of identified reservoirs, fluid contacts demarcation and fluid types’ determination. The interpreted data were thereafter loaded into Microsoft Excel environment in order to adopt suitable statistical relations for the estimation of Vsh, K, Sw and Sh. Exploration of about 59.4% HC with NaOH, 64.5% HC with KOH, 69.5% HC with NH4OH and 78.5% HC with LiOH were discovered after the (EOR) flooding process. Comparison of the Vsh, K, Sw and Sh values before EOR with the values after EOR further showed that the reservoirs produced more HC with EOR. This study concluded that more hydrocarbon saturation can be achieved from reservoirs when EOR is carried out.
العامل السكاني وأثره في تحقيق الأمن الغذائي في العراق
Authors: هندي زهراء عباس
Published: February 2023

إن تحقيق الأمن الغذائي شرطٌ أساسيٌ لنجاح التنمية الاقتصادية ومكملٌ للأمن السياسي والعسكري والاقتصادي وكذلك ضمان الحد الأدنى من الاحتياجات الغذائية للسكان. وانطلاقاً من أهمية الغذاء لسكان العراق وعلاقته بحجمهم ونموهم السكاني، ومحاولة توفير الغذاء لضمان تلبية احتياجاتهم وتجنب الوقوع تحت ضغوط الدول المنتجة للغذاء الكبرى، فقد هدفت الدراسة للتعرف على واقع السكان وأثر ذلك في تحقيق الأمن الغذائي في العراق، وتوصلت الدراسة إلى مجموعة من النتائج أبرزها: إن العراق يعاني من تدني أمنه الغذائي بشكل خطير يستدعي وقفه جاده لكل وطني وشريف للنهوض به وإلا فإن الكارثة لا يسلم منها أحد سواء الأجيال الحاضرة أو المستقبلة، كما أنَّ واقع الأمن الغذائي بدأ بالتردي في بداية السبعينات، وكانت نسبة الاكتفاء الذاتي من المجموعات الغذائية الاستراتيجية والرئيسية عاليةً جداً، ولكن حصل انهيار فيها في عقد الثمانينات، فتراجع الاكتفاء الذاتي من مجموعة الحبوب إلى 31%، ثم شهد ارتفاعاً في عقدي التسعينات ومنتصف العقد الأول من القرن الحادي عشر، إذ بلغ من هذه المجموعة 53% و56% على التوالي، ولكن هذا المستوى ما زال غير مطمأن، بسبب سعة الفجوة الكمية من السلع الغذائية.
مظاهر حضور المغرب والأندلس في بعض أعمال سرخيو ماثياس
Authors: العمري رضوان
Published: February 2023

ترمي هذه الدراسة إلى الوقوف على تجربة أحد أبرز الشعراء الشيليين، سرخيو ماثياس، الذي صال وجال في البلاد المغربية والعربية وأقام فيها في حقب معينة، وسكنها فسكنته أمكنتها، وأصابته فتنة الثقافة المغربية والعربية الملتحفة بجلباب أندلسية، ما حرك وجدانه، وأطلق العنان لقريحته ليجود علينا بقصائد شعرية تسكنها لغة النوستالجيا والحنين إلى الماضي. نظم ماثياس قصائد تتغنى بمدينة تطوان وحدائقها، وكرم أناسها، وألف دواوين وشعرية، ونثرية. ويعد كتابه "الحضور العربي في أدب أمريكا اللاتينية، بمثابة ببليوجرافيا وصفية لمعظم كتاب أمريكا اللاتينية الذين أتوا على ذكر مظاهر الثقافة المغربية والعربية في أعمالهم. تجربة غنية، رأينا أنها تستحق دراسة وافية للتعرف على صور الثقافة العربية، والمغربية، مدينة تطوان بوجه خاص، بعيون شيلية أمريكية لاتينية، وهو مطمحنا من هذا المقال، الذي قسمناه إلى مدخل عام، تطرقنا فيه إلى جزء مقتضب من المشترك الثقافي بين المغرب وأمريكا اللاتينية، وسيرة مقتضبة لسرخيو ماثياس، متضمنة لأبرز أعماله، ووقفنا على بعض الصور التي نقلها عن المغاربة والمغرب من خلال نماذج مختارة من بعض قصائده، ثم خلاصات عامة للدراسة.
نشأة الصناعات الكبيرة وتطورها ومشكلاتها في محافظة ذي قار
Authors: دخيل نصير طالب , العلي كفاية عبد الله عبد العباس
Published: February 2023

تناول الدراسة مفهوم الصناعات التحويلية وأهميتها وتطورها التاريخي في محافظة ذي قار لسنة 2021، بينما تناول المبحث الثاني مشكلات الصناعات التحويلية الكبيرة في المحافظة، أما هدف الدراسة هو دراسة واقع الصناعات الكبيرة والوقوف على أهم المشكلات، واعتمدت الدراسة المنهج النظامي والتاريخي، ومن أهم النتائج التي توصلت لها الدراسة؛ تعد سنة 1970 البداية الفعلية لتطور الصناعات التحويلية الكبيرة في محافظة ذي قار، فضلا عن أن مشكلة الأرض أيضاً تتمثل في زحف استعمالات الأرض الأخرى نحو المنشآت الصناعية كما في كل من منشآت أور العامة (القابلوات والأسلاك والألمنيوم ) والنسيج، ومنشآت طحن الحبوب ومجمعات منشآت الطابوق لاسيما القديمة منها التي كانت يوماً ما بعيدة عن المناطق والتجمعات السكنية.
جريمة الإرهاب على ضوء أحكام القانون الدولي العام
Authors: القاضي محمد عبد المالك
Published: February 2023

تناولت الدراسة ماهية الإرهاب في القانون الدولي الإنساني، مستخدما الباحث المنهج القانوني، فجاءت الدراسة عبارة عن استقراء لبعض النصوص القانونية، وعرض مبسط لتعريف الإرهاب الدولي على صعيد الفقه العربي والغربي، وبيان أهم الاتفاقيات الدولية التي ساهمت في وضع التعريف، كما بينا عوامل الإرهاب الدولي التي تشكل دافع لارتكاب الجرائم الإرهابية والتطور التاريخي لها. وتناولنا طبيعة الأعمال الإرهابية وتمييز الإرهاب الدولي عن بعض المصطلحات المشابهة له وأهمها المقاومة الشعبية وحق الدفاع الشرعي عن النفس، وبيان أبرز الفروقات بينهما، وأشرنا للجهود الدولية في إطار الأجهزة العالمية وأهمها الإنتربول الدولي والأمم المتحدة، ودورها الكبير عبر محطات تاريخية للحد من الجرائم الإرهابية. وتوصلت الدراسة إلى العديد من النتائج أهمها أن مشكلة التعريف ستبقى قائمة رغم الجهود المبذولة في مكافحتها حتى يتم وضع تعريف جامع ومحدد لها دون أي اعتبارات سياسية، والعمل على تجريم الإرهاب في التشريعات الوطنية بما يتناسب مع الاتفاقيات الدولية.
تجنيس الفضاء في الكتابة النسوية المغربية المعاصرة: رواية مخالب المتعة لفاتحة مرشيد كدراسة حالة
Authors: حدا عبد الكريم ايت
Published: February 2023

يحاول هذا المقال تسليط الضوء الكتابة النسوية المغربية المعاصرة التي تعكس التحولات الاجتماعية والمكانية في المغرب في عصر العولمة. بناء على رؤى عالمة الاجتماع المغربية فاطمة المرنيسي وكذلك افكار بعض رائدات الجغرافيا البشرية النسوية، مثل دورين ماسي وإليزابيث ويلسون، يوضح المقال أن روايات الكاتبة المغربية فاتحة مرشيد، خاصة رواية مخالب المتعة، تنتج تمثيلات للفضاء والجنس تعطل التقسيمات المكانية الجنسانية المتضمنة في النظام الاجتماعي الأبوي المغربي. بالاعتماد على التحليل النصي للرواية (مخالب المتعة) والمرتكز على نظريات الجغرافية البشرية النسوية حول تجنيس الفضاء، يوضح المقال أن التمثيلات المكانية والجنسانية في رواية مخالب المتعة تزعزع استقرار الهرمية وتتحدى العلاقات التقليدية بين الجنسين داخل المجتمع المغربي وأيضًا تعكس التحول فيما يتعلق بنظرة المرأة للجنس في زمن العولمة.
Biogenic Silver Nanoparticles from Stereospermum kunthianum Cham Stem Bark Extract: Synthesis, Characterization, In Vitro Antimicrobial Study and Cytotoxicity Effects Against Brine Shrimp Artemia
Authors: D. Kabiru H. , B. Ahmad K. , M. Bello N. , E. Chiegero C.
Published: February 2023

Metal nanoparticles as a category of nanomaterial are receiving interest due to their wide range of applications including in biomedical fields. Among these nanoparticles, silver nanoparticles are the most extensively studied for medical applications because they have been proven to exhibit excellent activity against a wide range of medically significant pathogenic microorganisms, including bacteria, viruses, fungi, and yeasts. In this work, silver nanoparticles were biogenically synthesized using the stem bark extract of Stereospermum kunthianum Cham as capping agent. Physicochemical properties, antioxidant activity, antimicrobial properties and in vitro cytotoxicity of the synthesized AgNPs were studied following standard procedures. UV-Vis studies show broad absorbance peak of the nanoparticles between 430 and 450 nm, SEM image shows that some of the synthesized nanoparticles are near spherical shape with many of the particles appear to have irregular shapes while the material average crystalline size from the XRD analysis was 27.878 mm. The synthesized AgNPs exhibits moderate antioxidant activity with IC50 value of 124.84 μg/mL. Among the microorganism tested, the AgNPs shows more activity against Staphylococcus aureus than Salmonella typhi and Candida albicans. Brine shrimp lethality test of the synthesized AgNPs indicates some level of cytotoxicity with LC50 of 461.850 μg/mL. using biological materials as reducing agents remains best green approach for the synthesis of silver nanoparticles.
Umgang mit kinder- und jugendpornographischen Unterlagen in Archiven
Authors: Boetticher Eike Alexander v.
Published: February 2023

Der Umgang mit kinder- bzw. jugendpornographischen Unterlagen in Archiven hat seit einigen Jahren eine erhöhte Sensibilität erfahren. Auslöser waren zum einem der Fund von entsprechenden Fotos in einem Lehrer-Nachlass im Staatsarchiv Wiesbaden sowie die Übernahme von Unterlagen der Odenwald-Schule durch das Hessische Staatsarchiv Darmstadt, die den dort stattgefundenen sexuellen Missbrauch an Kindern und Jugendlichen dokumentieren. In einem ersten Teil soll mit diesem Aufsatz untersucht werden, inwiefern die Vorlage von Unterlagen dieser Art im Lesesaal eines Archivs nach § 184b bzw. § 184c StGB strafbar und unter welchen Voraussetzungen aus der Sicht des Strafrechts eine Nutzung durch die wissenschaftliche Forschung möglich ist.
Mein Zeitgeist
Authors: Marten Rainer
Published: February 2023

In diesem biografisch gesättigten Essay entfaltet der Philosoph Rainer Marten vor dem Hintergrund des neoliberalen Zeitgeists der Silicon Valley-Gegenwart die Essenz seines Denkens in kraftvollen Zügen. Im Angesicht des eigenen Lebensendes legt er an unsere Zeit den Maßstab überzeitlicher Lehren der Philosophie, Theologie und Lebenskunst. Mit wachem Blick für die Verwerfungen unserer Zeit tritt er ein für die Schönheit des fragilen Lebens, dessen Grund er in der Poesie der Notwendigkeit sieht. Im Nachdenken über Technomessianismus, Verführung des Bösen und Künstliche Intelligenz stärkt er sein Konzept des Humanums, plädiert für das Leben als Kunstwerk und gegen dessen Instrumentalisierung.
Schutz der Vertragspartner aus § 103 InsO
Authors: Hoeg Elisabeth
Published: February 2023

This dissertation clarifies a largely unresolved problem about executory contracts in bankruptcy proceedings. Particularly, how to deal with burdens on creditors that arise while waiting for assumption or rejection. It contains an assessment of whether bankruptcy law should be supplemented by new compensation regimes. In doing so, the author draws on all sources available to legal scholars: Legal history, systematic considerations, comparisons within the legal system. A review shows that the procedural burdens have intensified in recent decades. The author recognizes the need for reform and presents a draft law.
APPLICATION IN INITIAL VALUE PROBLEMS VIA OPERATIONAL TECHNIQUES ON A CONTOUR INTEGRAL FOR SRIVASTAVA - DAOUST FUNCTION OF TWO VARIABLES
Authors: Kumar Hemant
Published: February 2023

In this paper, we introduce the contour integrals for two variables functions namely as Srivastava - Daoust and generalized Kampé de Fériet functions and then, by the fractional and partial derivatives operational techniques, obtain their many results and relations for various special functions useful in quantum mechanical fields. Again then, apply them to solve the fractional calculus problems involving the initial values with the Caputo fractional derivatives and Riemann - Liouville fractional integrals.
STUDY OF Alfvén WAVES USING MAGNETO HYDRODYNAMIC EQUATIONS IN SOLAR ATMOSPHERE
Authors: S. Pande  , H. Bisht  , Mathpal M. C. , C. Pant  , B. Pande  , M. C. Joshi
Published: February 2023

This paper presents a three dimensional analysis of the properties of magneto hydrodynamic waves. A quantitative formulation of magneto hydrodynamic Alfvén waves is studied. On considering the motion in ordinary fluid, it is observed that the propagation of low frequency waves is only in the form of pressure waves. We have focused on such modes of propagation of incompressible fluid or plasma in magnetic field for which, the speed does not surpass the speed of sound. The value of conductivity is taken to be infinity and viscosity negligible. In such a case, the sum of the pressures of the field induced and the pressure of the plasma is independent of all the coordinates. The kinetic energy density of wave motion and the energy density of the field induced by the perturbation come out to be equal in both phase and amplitude. The study of the effect of large but finite conductivity for small Joule losses reveal that the waves remain periodic, but it is observed that the amplitude of the waves decreases continuously and exponentially at a slow pace.
Clinical and Histopathological Evaluation of Forty-one Cases of Pediatric Granuloma Annulare
Authors: Koku Aksu Ayse Esra , İlhan Erdil Dilara , Manav Baş Vildan , Büşra Türk Cemre , Leblebici Cem , Tellal Ebru Sarıkaya
Published: February 2023

Introduction: Granuloma annulare (GA) is a non-infectious granulomatous disease that can affect children and adults. Although many studies have been conducted adult GA patients, the literature on pediatric GA cases is limited.
Objectives: Therefore, this study aimed to examine the demographic, clinical, and pathological features of pediatric GA cases.
Methods: This study was performed retrospectively in a single-center tertiary dermatology hospital. Demographic characteristics and clinical and histopathological features were recorded.
Results: Forty-one participants were included in this study, of which 66% were female. The mean age was 3.8 ± 2.6 years, and the mean lesion duration was 7.5 ± 10.3 months. The involvement of 78% of the patients was localized, and the remaining 22% was generalized. Asthma (30%) was the most common comorbid disease. Histopathological examination was performed on twenty-one patients, and the infiltrate pattern was interstitial in 71% of the cases and palisadic in 29%. Generalized distribution, trunk involvement, and concomitant disease tended to be higher in patients with an interstitial pattern than in those with a palisadic pattern.
Conclusions: Atopy and asthma should be questioned in pediatric GA cases. There are differences between involvement, distribution, concomitant disease, and histopathological patterns, which may indicate differences in pathogenesis.
Demographics of Skin Cancer Knowledge Among Middle and High Schoolers in Texas
Authors: Zamil Dina , Fu Shangyi , Majd Zahra , Powell Emily , Zamil Jenna , Nawas Zeena , Orengo Ida
Published: February 2023

Introduction: Adolescents, an age group that can reduce sun exposure early, may benefit from school-based skin cancer education programs. Literature regarding the demographics of melanoma knowledge is sparse.
Objectives: This study sought to evaluate melanoma knowledge among students in Texas viewing John Wayne Cancer Foundation Block the Blaze (JWCFBTB) presentations and identify group differences with regard to sociodemographic factors.
Methods: Before JWCFBTB presentations delivered in Houston and Dallas by health professions students, a pre-presentation melanoma knowledge quiz was distributed. This survey was adapted from a 2000 study evaluating melanoma knowledge in middle and high schoolers in Houston and Dallas. Respondents were also asked to provide their gender, age, grade, race, parent education level, and whether they are first-generation American. ANOVA and Tukey tests were used to evaluate demographic group differences in scores. Logistic regression models determined predictors of answering selected true/false questions correctly.
Results: One-way ANOVA tests showed statistically significant group differences in pre-test scores for all demographic factors evaluated. Females, Whites/Caucasians, students whose parents hold graduate degrees, and older students had higher scores. Black students and non-first-generation Americans were more likely to answer selected commonly missed questions correctly.
Conclusions: Results from 2000 and 2020-2021 indicate older students from higher grade levels know more about melanoma, suggesting adolescents may benefit from earlier skin cancer education. Racial minorities and individuals of low socioeconomic status, who suffer from disparities in melanoma treatment and mortality, showed poorer melanoma knowledge. Targeting skin cancer education to disadvantaged schools may help remedy such gaps.
What Do Patients Want To See On Social Media? Evidence From A Two-Year Experiment
Authors: Barrutia Leire , Vega-Gutiérrez Jes´ús , Santamarina-Albertos Alba
Published: February 2023

Introduction: Dermatological information on social media is dominated by misleading and potentially harmful content from nonexperts. Literature suggests that, to address this issue, dermatologists should develop an online presence. However, successful presence of dermatologists on social media has been criticized for focusing on cosmetic dermatology and not representing the broad spectrum of the specialty.

Objectives: The aim of this study was to systematically analyze which dermatological topics interest the public most, and to find out whether it is feasible for a dermatologist to become influential on social media while presenting all dermatological topics equally.

Methods: The study was performed on an educational dermatology YouTube channel. The 101 videos published in a two-year period were divided into cosmetic (51 videos) and medical dermatology (50 videos). Student’s t-test was conducted to determine whether there were significant differences in views. Medical dermatology videos were then classified into three categories: Acne, facial dermatoses (excluding acne) and other dermatological diseases. A Kruskal-Wallis test was used to compare these three categories and cosmetic dermatology.

Results: When comparing cosmetic and medical dermatology, no significant differences were found. When comparing the four categories, cosmetic dermatology and acne were found to generate significantly more views that other dermatological diseases.

Conclusions: The public seems to be particularly interested in cosmetic dermatology and acne. This might make it challenging to become successful on social media while presenting a balanced portray of dermatology. However, focusing on popular topics can provide a real chance to be influential and protect vulnerable people from misinformation.
Narrative Review of Drug-Associated Nail Toxicities in Oncologic Patients
Authors: Emvalomati Anastasia , Oflidou Valentina , Papageorgiou Chryssoula , Kemanetzi Christina , Giannouli Maria , Kalloniati Evangelia , Efthymiadis Konstantinos , Koukoutzeli Chrysanthi , Timotheadou Eleni , Trigoni Anastasia , Patsastsi Aikaterini , Lazaridou Elizabeth , Apalla Zoe , Trakatelli Myrto
Published: February 2023

Introduction Nail toxicity represents one of the most common cutaneous adverse effects of both classic chemotherapeutic agents and new oncologic drugs, including targeted treatments and immunotherapy.
Objectives We aimed to provide a comprehensive literature review of nail toxicities derived from conventional chemotherapeutic agents, targeted therapies (EGFR inhibitors, multikinase inhibitors, BRAF and MEK inhibitors) and immune checkpoint inhibitors (ICIs), including clinical presentation, implicated drugs and approaches for prevention and management.
Methods Retrieved literature from PubMed registry database was reviewed to include all articles published up to May 2021 relevant to the clinical presentation, diagnosis, incidence, prevention, and treatment of oncologic treatment-induced nail toxicity. The was searched for relevant studies.
Results A wide spectrum of nail toxicities is associated with both, conventional and newer anticancer agents. The frequency of nail involvement, especially with immunotherapy and new targeted agents remains unknown and patients with different cancer types receiving different regimens may develop the same nail disorder, whereas patients with the same type of cancer under the same chemotherapeutic treatment may develop different types of nail alterations. The underlying mechanisms of the varying individual susceptibility and the diverse nail responses to various anticancer treatments need further investigation.
Conclusion Early recognition and treatment of nail toxicities can minimize their impact, allowing better adherence to conventional and newer oncologic treatments. Dermatologists, oncologists and other implicated physicians should be aware of these burdensome adverse effects in order to guide management and prevent impairment of patients’ quality of life.
Early Exposure of Antibiotic as A Risk Factor for Gastrointestinal Disorders: An Evidence-Based Case Report
Authors: Barnita Ezy , Ongko Lukito , Kadim Muzal
Published: February 2023

Background: Incidence rate of pediatric onset inflammatory bowel disease (IBD) has been increasing worldwide particularly in the rapidly growing countries. It has been hypothesized that environmental factors such as method of delivery, rural or urban living environment and the use of antibiotics, may play significant roles. Antibiotics are known to alter gut microbiome and henceforth may be the rational mechanism in the development of gastrointestinal autoimmune diseases.
Methods: Literature search was performed on 3 international databases (PubMed, PubMed PICO and Google Scholar) by using relevant keywords based on clinical question.
Results: Two systematic reviews were included in this study. Both studies reported strong evidence regarding the increase risk of occurrence for inflammatory bowel disease and celiac disease after exposure of antibiotics particularly in young age
Discussion: At young age, the immune system and gut microbiota is considered to be unstable and prone to disruption particularly by exposure of antibiotics. Antibiotics is known to weaken mucosal barrier of the gut which facilitates translocation of commensal bacteria. Translocation process together with the imbalance ratio of T-helper 1 and T-helper 2 may be the pathogenesis behind the development of chronic gastrointestinal diseases.
Conclusion: There is strong evidence that early life exposure to antibiotic is associated with the development of IBD and Celiac disease in childhood. Therefore, it is critical for all healthcare workers to adhere to strict guidelines regarding the rationality on when to prescribe antibiotics particularly in children of young age.
Replacing Alteplase with Tenecteplase: Is the Time Ripe?
Authors: Singh Nishita , Menon Bijoy K. , Dmytriw Adam A. , Regenhardt Robert W. , Hirsch Joshua A. , Ganesh Aravind
Published: February 2023

Thrombolysis for acute ischemic stroke has predominantly been with alteplase for over a quarter of a century. In recent years, with trials showing evidence of higher rates of successful reperfusion, similar safety profile and efficacy of tenecteplase (TNK) as compared to alteplase, TNK has now emerged as another potential choice for thrombolysis in acute ischemic stroke. In this review, we will focus on these recent advances, aiming: (1) to provide a brief overview of thrombolysis in stroke; (2) to provide comparisons between alteplase and TNK for clinical, imaging, and safety outcomes; (3) to focus on key subgroups of interest to understand if there is an advantage of using TNK over alteplase or vice-versa, to review available evidence on role of TNK in intra-arterial thrombolysis, as bridging therapy and in mobile stroke units; and (4) to summarize what to expect in the near future from recently completed trials and propose areas for future research on this evolving topic. We present compelling data from several trials regarding the safety and efficacy of TNK in acute ischemic stroke along with completed yet unpublished trials that will help provide insight into these unanswered questions.
Neuroimaging of Acute Ischemic Stroke: Multimodal Imaging Approach for Acute Endovascular Therapy
Authors: Abdalkader Mohamad , Siegler James E. , Lee Jin Soo , Yaghi Shadi , Qiu Zhongming , Huo Xiaochuan , Miao Zhongrong , Campbell Bruce C.V. , Nguyen Thanh N.
Published: February 2023

Advances in acute ischemic stroke (AIS) treatment have been contingent on innovations in neuroimaging. Neuroimaging plays a pivotal role in the diagnosis and prognosis of ischemic stroke and large vessel occlusion, enabling triage decisions in the emergent care of the stroke patient. Current imaging protocols for acute stroke are dependent on the available resources and clinicians’ preferences and experiences. In addition, differential application of neuroimaging in medical decision-making, and the rapidly growing evidence to support varying paradigms have outpaced guideline-based recommendations for selecting patients to receive intravenous or endovascular treatment. In this review, we aimed to discuss the various imaging modalities and approaches used in the diagnosis and treatment of AIS.
Problematika Peserta Didik dalam Menghafal Al-Quran di MAN 3 Agam Kubang Putih
Authors: Putra Bobi , Hayati Hayati
Published: February 2023

The main problem of the research here is the lack of motivation in students to memorize the Al-Quran. Then there are still many students' mistakes in reading the Koran, both in terms of its makhraj, short length and the rules for reading the Koran from students so that it makes it difficult for students to memorize the Koran. The research method used by researchers is descriptive qualitative research, namely data collected in the form of words, pictures, not numbers. The key informants are students, while the supporting informants are PAI teachers and other teachers. The techniques used to collect data are observation, interviews and documentation. To analyze the data, researchers used Miles and Huberman's analysis techniques, namely Data Reduction, Data Display (data display), and Conclusion Drawing or verification. In order for the data collected to be valid, the researcher uses the validity technique by means of triangulation. Based on the results of research found in the field, in terms of implementation, the process or stages that students go through are going quite well. However, there are various problems faced by students in memorizing the Qur'an both internally and externally. From an internal perspective, it can be seen from a feeling of laziness or lack of motivation within oneself, not focusing when memorizing the Al-Quran, not repeating memorization (Murajaah) at home and so on. Meanwhile, from an external perspective, it is because of friends' distractions, more focus on playing with cellphones, lots of school assignments, and not being able to divide time properly and effectively. Therefore, to overcome these problems, students need to instill sincere intentions in their hearts and earnestly memorize the Al-Quran. Besides that, it is also expected that parents and teachers can work together in increasing the potential for memorizing the Al-Quran of students. so that students in the future are even more proficient in reading and memorizing the Al-Quran.
MODEL MISI GEREJA MENGHADAPI AJARAN SESAT DALAM SURAT PAULUS KEPADA TIMOTIUS SEBAGAI PEGANGAN GEREJA BETHEL INDONESIA MOJOPAHIT JEMBER
Authors: Rusli Djohan
Published: February 2023

Umat Kristen perlu memahami model misi gereja dalam menghadapi ajaran sesat sebagai pegangan hidup pada masa kini. Dengan pengetahuan jemaat tentang firman Tuhan yang sangat minim, sementara kemajuan informasi dan teknologi sangat pesat terutama di bidang media sosial, menjadi ancaman serius bagi gereja dengan tayangan beraneka-ragam pengajaran yang tidak dapat dipertanggungjawabkan kebenarannya, yang tidak sesuai dengan Injil Yesus Kristus. Dari hasil penelitian dan kajian teoretik terungkap bahwa diperlukan model misi gereja yang mengikuti misi Kristus, yaitu: model penginjilan, model pemuridan, model pembinaan jemaat, dan pengajaran dalam menghadapi ajaran sesat, di mana semua model misi gereja tersebut berfokus pada Injil Yesus Kristus yang menyelamatkan. Penelitian dilakukan dengan metode kualitatif untuk memperoleh data yang akurat, dengan pendekatan teologis, kepustakaan, dan studi kasus untuk menghasilkan data yang deskriptif. Tujuan penulisan ini untuk menemukan model misi gereja dalam menghadapi ajaran sesat sebagai pegangan gereja.
Kompetensi Peradilan Tata Usaha Negara Terhadap Perihal Acara Pembuktian Dalam Sengketa Tata Usaha Negara
Authors: Muqsitha Shafira , Wibowo Arif
Published: February 2023

Indonesia merupakan negara hukum yang berdasarkan pancasila dengan tujuan mewujudkan tata kehidupan berbangsa dan bernegara yang aman, sejahtera serta tertib sebagaimana kedudukan hukum warga negara dalam masyarakat terjamin. Negara adalah suatu organisasi kekuasaan (organisasi politik) yang dipimpin oleh Pemerintahan terpusat yang bertugas mempertahankan negara, menyelenggarakan ketertiban umum serta mensejahterakan seluruh warga negara. Dalam pelaksanaannya sering terjadi perselisihan dan sengketa antara Badan dan Pejabat Tata Usaha Negara dengan warga masyarakat. Sengketa tersebut diselesaikan melalui Peradilan Tata Usaha Negara. Tulisan ini membahas tentang perihal acara pembuktian dalam sengketa tata usaha negara. Sebab, sebagaimana diketahui bahwa suatu masalah yang sangat penting dalam hukum pembuktian adalah masalah beban pembuktian. Pembagian beban pembuktian itu harus dilakukan dengan adil dan tidak berat sebelah, karena suatu pembagian beban pembuktian yang berat sebelah berarti apriori menjerumuskan pihak yang menerima beban yang terlampau berat dalam jurang kekalahan. Sedangkan membuktikan atau memberikan pembuktian adalah dengan alat-alat pembuktian tertentu memberikan suatu tingkatan kepastian yang sesuai dengan penalaran tentang eksistensi fakta-fakta (hukum) yang disengketakan. Ditentukan dalam pasal 100 ayat (1) Undang-Undang N0. 5 Tahun 1986 tentang Peradilan Tata Usaha Negara berupa surat atau tulisan, keterangan ahli, keterangan saksi, pengakuan para pihak dan pengetahuan hakim.
Actualización de los resultados de la Terapia de Presión Negativa: Revisión Sistemática.
Authors: Llamas Fernández Sara
Published: February 2023

La Terapia de Presión Negativa (TPN) es una técnica alternativa para el cierre de lesiones tales como heridas crónicas, úlceras por presión o dehiscencias quirúrgicas. Su uso se ha extendido desde los años 90 con los doctores Louis Argenta y Michael Morykwas. En la actualidad, se mantiene como una alternativa a los métodos de cicatrización tradicionales. El objetivo que persigue la revisión sistemática trata de resumir los últimos resultados obtenidos con la aplicación de la TPN mediante el análisis de las últimas publicaciones realizadas en las diferentes bases de datos. Además, se evalúan las mejoras que ésta produce en el ámbito económico y en la calidad de vida de los pacientes.
Los resultados obtenidos han demostrado la efectividad de la TPN en el cierre de las lesiones analizadas en comparación con las técnicas tradicionales de curación, disminuyendo la estancia hospitalaria y los costes añadidos. Sin embargo, se encuentra como limitación que no existe un protocolo estandarizado sobre la aplicación de la terapia ni de la duración correcta de la misma. La muestra de estudio prevalente ha sido el adulto mayor, en el que la funcionalidad de la piel se ve afectada por la edad y por la patología subyacente. En lo que respecta a la calidad de vida de los pacientes se ha verificado su efectividad, disminuyendo el dolor de las lesiones y el tiempo de curación.
Se puede concluir, por tanto, que la TPN es una técnica efectiva en el cierre de la lesión pero se hace necesario un mayor estudio de la técnica para asegurar un uso correcto y seguro, aplicado de la misma forma por todos los profesionales sanitarios.
Single-cell transcriptome profiles of Drosophila fruitless-expressing neurons from both sexes
Authors: Palmateer Colleen M , Artikis Catherina , Brovero Savannah G , Friedman Benjamin , Gresham Alexis , Arbeitman Michelle N
Published: February 2023

Drosophila melanogasterreproductive behaviors are orchestrated byfruitlessneurons. We performed single-cell RNA-sequencing on pupal neurons that produce sex-specifically splicedfrutranscripts, thefru P1-expressingneurons. Uniform Manifold Approximation and Projection (UMAP) with clustering generates an atlas containing 113 clusters. While the male and female neurons overlap in UMAP space, more than half the clusters have sex differences in neuron number, and nearly all clusters display sex-differential expression. Based on an examination of enriched marker genes, we annotate clusters as circadian clock neurons, mushroom body Kenyon cell neurons, neurotransmitter- and/or neuropeptide-producing, and those that expressdoublesex. Marker gene analyses also show that genes that encode members of the immunoglobulin superfamily of cell adhesion molecules, transcription factors, neuropeptides, neuropeptide receptors, and Wnts have unique patterns of enriched expression across the clusters. In vivo spatial gene expression links to the clusters are examined. A functional analysis offru P1circadian neurons shows they have dimorphic roles in activity and period length. Given that most clusters are comprised of male and female neurons indicates that the sexes havefru P1neurons with common gene expression programs. Sex-specific expression is overlaid on this program, to build the potential for vastly different sex-specific behaviors.
Muscle calcium stress cleaves junctophilin1, unleashing a gene regulatory program predicted to correct glucose dysregulation
Authors: Tammineni Eshwar R , Figueroa Lourdes , Manno Carlo , Varma Disha , Kraeva Natalia , Ibarra Carlos A , Klip Amira , Riazi Sheila , Rios Eduardo
Published: February 2023

Calcium ion movements between cellular stores and the cytosol govern muscle contraction, the most energy-consuming function in mammals, which confers skeletal myofibers a pivotal role in glycemia regulation. Chronic myoplasmic calcium elevation (“calcium stress”), found in malignant hyperthermia-susceptible (MHS) patients and multiple myopathies, has been suggested to underlie the progression from hyperglycemia to insulin resistance. What drives such progression remains elusive. We find that muscle cells derived from MHS patients have increased content of an activated fragment of GSK3β — a specialized kinase that inhibits glycogen synthase, impairing glucose utilization and delineating a path to hyperglycemia. We also find decreased content of junctophilin1, an essential structural protein that colocalizes in the couplon with the voltage-sensing CaV1.1, the calcium channel RyR1 and calpain1, accompanied by an increase in a 44 kDa junctophilin1 fragment (JPh44) that moves into nuclei. We trace these changes to activated proteolysis by calpain1, secondary to increased myoplasmic calcium. We demonstrate that a JPh44-like construct induces transcriptional changes predictive of increased glucose utilization in myoblasts, including less transcription and translation of GSK3β and decreased transcription of proteins that reduce utilization of glucose. These effects reveal a stress-adaptive response, mediated by the novel regulator of transcription JPh44.
Endo-lysosomal assembly variations among human leukocyte antigen class I (HLA class I) allotypes
Authors: Olson Eli , Ceccarelli Theadora , Raghavan Malini
Published: February 2023

The extreme polymorphisms of human leukocyte antigen class I (HLA class I) proteins enable the presentation of diverse peptides to cytotoxic T lymphocytes. The canonical endoplasmic reticulum (ER) HLA class I assembly pathway enables presentation of cytosolic peptides, but effective intracellular surveillance requires multi-compartmental antigen sampling. Endo-lysosomes are generally sites of HLA class II assembly, but human monocytes and monocyte-derived dendritic cells (moDCs) also contain significant reserves of endo-lysosomal HLA class I molecules. We hypothesized variable influences of HLA class I polymorphisms upon outcomes of endo-lysosomal trafficking, as the stabilities and peptide occupancies of cell surface HLA class I molecules are variable. Consistent with this model, when the endo-lysosomal pH of moDCs is disrupted, HLA-B allotypes display varying propensities for reductions in surface expression, with HLA-B*08:01 or HLA-B*35:01 being among the most resistant or sensitive, respectively, among eight tested HLA-B allotypes. Perturbations of moDC endo-lysosomal pH result in accumulation of HLA-B*35:01 in LAMP1+ compartments and increase HLA-B*35:01 peptide receptivity. These findings reveal the intersection of the vacuolar cross-presentation pathway with a constitutive assembly pathway for some HLA-B allotypes. Notably, cross-presentation of epitopes derived from two soluble antigens was also more efficient for B*35:01 compared to B*08:01, even when matched for T cell response sensitivity, and more affected by cathepsin inhibition. Thus, HLA class I polymorphisms dictate the degree of endo-lysosomal assembly, which can supplement ER assembly for constitutive HLA class I expression and increase the efficiency of cross-presentation.
N-terminal domain on dystroglycan enables LARGE1 to extend matriglycan on α-dystroglycan and prevents muscular dystrophy
Authors: Okuma Hidehiko , Hord Jeffrey M , Chandel Ishita , Venzke David , Anderson Mary E , Walimbe Ameya S , Joseph Soumya , Gastel Zeita , Hara Yuji , Saito Fumiaki , Matsumura Kiichiro , Campbell Kevin P
Published: February 2023

Dystroglycan (DG) requires extensive post-translational processing and O-glycosylation to function as a receptor for extracellular matrix (ECM) proteins containing laminin-G (LG) domains. Matriglycan is an elongated polysaccharide of alternating xylose (Xyl) and glucuronic acid (GlcA) that binds with high affinity to ECM proteins with LG domains and is uniquely synthesized on α-dystroglycan (α-DG) by like-acetylglucosaminyltransferase-1 (LARGE1). Defects in the post-translational processing or O-glycosylation of α-DG that result in a shorter form of matriglycan reduce the size of α-DG and decrease laminin binding, leading to various forms of muscular dystrophy. Previously, we demonstrated that protein O-mannose kinase (POMK) is required for LARGE1 to generate full-length matriglycan on α-DG (~150–250 kDa) (Walimbe et al., 2020). Here, we show that LARGE1 can only synthesize a short, non-elongated form of matriglycan in mouse skeletal muscle that lacks the DG N-terminus (α-DGN), resulting in an ~100–125 kDa α-DG. This smaller form of α-DG binds laminin and maintains specific force but does not prevent muscle pathophysiology, including reduced force production after eccentric contractions (ECs) or abnormalities in the neuromuscular junctions. Collectively, our study demonstrates that α-DGN, like POMK, is required for LARGE1 to extend matriglycan to its full mature length on α-DG and thus prevent muscle pathophysiology.