bluuebunny/crossref_metadata_2025 huggingface dataset:
Psychometric properties of the English version of the Audio Processor Satisfaction Questionnaire (APSQ)
Authors: Felder Jenna , Amann Edda , Anderson Ilona , Stohl Joshua , Billinger-Finke Mareike
Published: September 2022

Objective

The Audio Processor Satisfaction Questionnaire (APSQ) is a standardized tool to measure a user’s satisfaction with their audio processor(s). It was first developed and validated in the German language. The purpose of the current study was to validate the English version of the APSQ.

Design

The 15 items of the APSQ were translated into English. Item and scale analyses assessed the quality of individual items and of the questionnaire in its entirety.

Study sample

Sixty-seven adults with hearing implants participated. Forty-six of them completed the questionnaire twice within 2–4 weeks.

Results

High mean values were obtained with total scores and with scores of the comfort, social life, and usability domains, indicating that users are generally satisfied with their audio processors. The questionnaire achieved good test-retest reliability with high internal consistency. A significant positive correlation between time since implantation and user satisfaction was found.

Conclusion

Results of the item and reliability analyses suggest that the English version of the APSQ is a valid and reliable tool to assess user satisfaction with their audio processor(s).
It’s made a really hard situation even more difficult: The impact of COVID-19 on families of children with chronic illness
Authors: McLoone Jordana , Wakefield Claire E. , Marshall Glenn M. , Pierce Kristine , Jaffe Adam , Bye Ann , Kennedy Sean E. , Drew Donna , Lingam Raghu
Published: September 2022

Objective

For over two years, the global COVID-19 pandemic has forced major transformations on health, social, and educational systems, with concomitant impacts on mental health. This study aimed to understand the unique and additional challenges faced by children with chronic illness and their families during the COVID-19 era.

Method

Parents of children receiving treatment for a chronic illness within the neurology, cancer, renal and respiratory clinics of Sydney Children’s Hospital were invited to participate. We used qualitative methodology, including a semi-structured interview guide, verbatim transcription, and thematic analysis supported by QSR NVivo.

Results

Thirteen parents of children receiving tertiary-level care, for nine chronic illnesses, participated. Parents reported intense fears relating to their ill child’s additional vulnerabilities, which included their risk of developing severe COVID-19 disease and the potential impact of COVID-19-related disruptions to accessing clinical care, medications, allied health support and daily care protocols should their parent contract COVID-19. Parents perceived telehealth as a highly convenient and preferred method for ongoing management of less complex healthcare needs. Parents reported that the accrual of additional stressors and responsibilities during the pandemic, experienced in combination with restricted social interaction and reduced access to usual support networks was detrimental to their own mental health. Hospital-based visitation restrictions reduced emotional support, coping, and resilience for both parents and children and in some cases led to marital discord, sibling distress, and financial loss. Supportive factors included increased time spent together at home during the pandemic and improved hygiene practices at school, which dramatically reduced the incidence of non-COVID-19-related communicable illnesses in chronically ill children.

Discussion

For families caring for a chronically ill child, COVID-19 made a difficult situation harder. The pandemic has highlighted the need for targeted psychosocial intervention for vulnerable families, to mitigate current mental health burden and prevent chronic psychological distress.
The 17-gene Genomic Prostate Score assay as a predictor of biochemical recurrence in men with intermediate and high-risk prostate cancer
Authors: Helfand Brian T. , Paterakos Michael , Wang Chi-Hsiung , Talaty Pooja , Abran John , Bennett John , Hall David W. , Lehman Amy , Aboushwareb Tamer
Published: September 2022

The validated 17-gene Oncotype DX Genomic Prostate Score® (GPS™) assay risk-stratifies prostate-cancer patients with localized disease. The assay has primarily been utilized in lower risk patients deciding between active surveillance versus definitive therapy. In this retrospective cohort study, we analyze the association of the GPS result with time to biochemical recurrence post-prostatectomy in patients with National Comprehensive Cancer Network® (NCCN) intermediate and higher risk prostate cancer. The 141 patients included in the study were from the NorthShore University HealthSystem diagnosed 2014–2019 with NCCN intermediate (n = 109) or higher risk (n = 32) prostate cancer, treated with radical prostatectomy 2015–2019. The association of GPS result with time to biochemical recurrence was evaluated using univariable and multivariable Cox proportional hazards models in 120 patients with unfavorable intermediate or higher risk. Median (interquartile range) follow-up time was 28 (20 to 38) months. The GPS result was significantly associated with time to biochemical recurrence as both a continuous and dichotomous variable in univariable (hazard ratio [HR] per 20 GPS units 2.36, 95% CI 1.45–3.80, p < 0.001; HR for GPS result 41–100 vs 0–40 3.28, 95% CI 1.61–7.19, p < 0.001) and in multivariable models accounting for NCCN risk group (HR per 20 GPS units 2.14, 95% CI 1.31–3.46, p = 0.003; HR for GPS result 41–100 vs 0–40 3.00, 95% CI 1.43–6.72, p = 0.003) or biopsy Gleason Score and diagnostic PSA or PSA density. These results indicate that the GPS assay was a strong predictor of biochemical recurrence after radical prostatectomy in this unfavorable intermediate and higher risk prostate cancer patient population.
Survival and lung function decline in patients with definite, probable and possible idiopathic pulmonary fibrosis treated with pirfenidone
Authors: Májek Ondřej , Gregor Jakub , Mogulkoć Nesrin , Lewandowska Katarzyna , Šterclová Martina , Müller Veronika , Hájková Marta , Kramer Mordechai R. , Tekavec-Trkanjec Jasna , Jovanović Dragana , Studnicka Michael , Stoeva Natalia , Kirchgässler Klaus-Uwe , Littnerová Simona , Dušek Ladislav , Vašáková Martina Koziar
Published: September 2022

Background

There is no clear evidence whether pirfenidone has a benefit in patients with probable or possible UIP, i.e. when idiopathic pulmonary fibrosis (IPF) is diagnosed with a lower degree of diagnostic certainty. We report on outcomes of treatment with pirfenidone in IPF patients diagnosed with various degrees of certainty.

Methods and findings

We followed patients in the multi-national European MultiPartner IPF Registry (EMPIRE) first seen between 2015 and 2018. Patients were assessed with HRCT, histopathology and received a multi-disciplinary team (MDT) IPF diagnosis. Endpoints of interest were overall survival (OS), progression-free survival (PFS) and lung function decline.

Results

A total of 1626 patients were analysed, treated with either pirfenidone (N = 808) or receiving no antifibrotic treatment (N = 818). When patients treated with pirfenidone were compared to patients not receiving antifibrotic treatment, OS (one-, two- and three-year probability of survival 0.871 vs 0.798; 0.728 vs 0.632; 0.579 vs 0.556, P = 0.002), and PFS (one-, two- and three-year probability of survival 0.597 vs 0.536; 0.309 vs 0.281; 0.158 vs 0.148, P = 0.043) was higher, and FVC decline smaller (-0.073 l/yr vs -0.169 l/yr, P = 0.017). The benefit of pirfenidone on OS and PFS was also seen in patients with probable or possible IPF.

Conclusions

This EMPIRE analysis confirms the favourable outcomes observed for pirfenidone treatment in patients with definitive IPF and indicates benefits also for patients with probable or possible IPF.
Orthostatic stress response in pediatric Fontan patients and the effect of ACE inhibition
Authors: Harteveld Lisette M. , Blom Nico A. , van Dijk J. Gert , Reijntjes Robert H. , van Someren Paul J. , Kerkhof Fabian I. , Kuipers Irene M. , Rammeloo Lukas A. J. , de Geus Eco J. C. , ten Harkel Arend D. J.
Published: September 2022

Background

Many cardiocirculatory mechanisms are involved in the adaptation to orthostatic stress. While these mechanisms may be impaired in Fontan patients. However, it is yet unclear how Fontan patients, who exhibit a critical fluid balance, respond to orthostatic stress. Angiotensin converting enzyme inhibitors are often prescribed to Fontan patients, but they may negatively influence orthostatic tolerance. Therefore, we evaluated the response to orthostatic stress in pediatric Fontan patients before and after treatment with enalapril.

Methods

Thirty-five Fontan patients (aged 14 years) with moderate-good systolic ventricular function without pre-existent enalapril treatment were included. Before and after a three-month enalapril treatment period, the hemodynamic response to head-up tilt test was evaluated by various parameters including cardiac index, blood pressure, cerebral blood flow, aortic stiffness and cardiac autonomous nervous activity. Thirty-four healthy subjects (aged 13 years) served as controls.

Results

Fontan patients had a decreased cerebral blood flow and increased aortic stiffness in the supine position compared to controls, while all other factors did not differ. Patients and controls showed a comparable response to head-up tilt test for most parameters. Twenty-seven patients completed the enalapril study with a mean dosage of 0.3±0.1mg/kg/day. Most parameters were unaffected by enalapril, only the percent decrease in cardiac index to tilt was higher after treatment, but the cardiac index during tilt was not lower (3.0L/min/m2 pre-enalapril versus 2.8L/min/m2 after treatment; P = 0.15).

Conclusion

Pediatric Fontan patients adequately respond to orthostasis with maintenance of blood pressure and cerebral blood flow and sufficient autonomic response. Enalapril treatment did not alter the response.

Clinical trial information

Scientific title: ACE inhibition in Fontan patients: its effect on body fluid regulation (sAFE-study).

The Netherlands National Trial Register: Trail NL6415. Registered 2017-07-20.

Trial information: https://www.trialregister.nl/trial/6415
Humans and the core partition: An agent-based modeling experiment
Authors: Collins Andrew J. , Etemadidavan Sheida
Published: September 2022

Although strategic coalition formation is traditionally modeled using cooperative game theory, behavioral game theorists have repeatedly shown that outcomes predicted by game theory are different from those generated by actual human behavior. To further explore these differences, in a cooperative game theory context, we experiment to compare the outcomes resulting from human participants’ behavior to those generated by a cooperative game theory solution mechanism called the core partition. Our experiment uses an interactive simulation of a glove game, a particular type of cooperative game, to collect the participant’s decision choices and their resultant outcomes. Two different glove games are considered, and the outputs from 62 trial games are analyzed. The experiment’s outcomes show that core coalitions, which are coalitions in a core partition, are found in about 42% of games. Though this number may seem low, a trial’s outcome is more complex than whether the human player finds a core coalition or not. Finding the core coalition depends on factors such as the other possible feasible solutions and the payoffs available from these solutions. These factors, and the complexity they generate, are discussed in the paper.
A conserved viral amphipathic helix governs the replication site-specific membrane association
Authors: Sathanantham Preethi , Zhao Wenhao , He Guijuan , Murray Austin , Fenech Emma , Diaz Arturo , Schuldiner Maya , Wang Xiaofeng
Published: September 2022

Positive-strand RNA viruses assemble their viral replication complexes (VRCs) on specific host organelle membranes, yet it is unclear how viral replication proteins recognize and what motifs or domains in viral replication proteins determine their destinations. We show here that an amphipathic helix, helix B in replication protein 1a of brome mosaic virus (BMV), is necessary for 1a’s localization to the nuclear endoplasmic reticulum (ER) membrane where BMV assembles its VRCs. Helix B is also sufficient to target soluble proteins to the nuclear ER membrane in yeast and plant cells. We further show that an equivalent helix in several plant- and human-infecting viruses of theAlsuviricetesclass targets fluorescent proteins to the organelle membranes where they form their VRCs, including ER, vacuole, and Golgi membranes. Our work reveals a conserved helix that governs the localization of VRCs among a group of viruses and points to a possible target for developing broad-spectrum antiviral strategies.
Dermatofibrosarcoma Protuberans - Case Report and Review of Literature
Authors: Namdev Seth  , Dushyant Varshney
Published: September 2022

Dermatofibrosarcoma protuberans (DFSP) is an uncommon, slow-growing, locally aggressive soft tissue sarcoma of the skin. The most common age of presentation for this entity of dermis is the third to fifth decade of life, whereas the most common site of involvement is the trunk and lower extremities, accounting for a total of 70 to 90 percent of the cases. Head and neck regions account for 10 to 15 percent of cases with the involvement of the scalp being the most common presentation in this region of the body.[1]

Although DFSP frequently shows local recurrence with the incidence of 20-50 percent of the cases, distant metastasis has been reported rarely.[2] So the cure rate in early diagnosed cases is high with a 10-year survival rate of 99.1 %, so prompt diagnosis of the entity is important along with awareness about the disease.[3] Here in this article, we are going to present a case of DFSP along with a review of the literature regarding the imaging characteristics of the disease.
A “severa vigilancia para que a epidemia não attingisse aqueles infelizes”: notas sobre a gripe espanhola, os vicentinos e o Asilo São Vicente de Paulo na cidade de Goiás em 1919
Authors: Bento de Souza Rildo
Published: September 2022

O objetivo deste artigo é analisar a pandemia da Gripe Espanhola entre 1918 e 1919 a partir do trabalho desenvolvido pela Sociedade São Vicente de Paulo na Cidade de Goiás. Pretende-se compreender como os vicentinos conseguiram livrar o Asilo São Vicente de Paulo do vírus e também o trabalho desenvolvido por essa sociedade leiga na cidade, ressaltando o caráter higiênico-sanitário desses atendimentos.
O destino do lixo urbano
Authors: Andrade Inês El-Jaick , Alves Gallo Éric
Published: September 2022

O artigo apresenta o contexto que culminou no projeto e construção do primeiro complexo de fornos de incineração de lixo urbano no Rio de Janeiro, ainda no século XIX. O ponto de partida da análise são documentos históricos (relatórios, plantas e imagens) disponíveis no Arquivo Geral da Cidade do Rio de Janeiro, acrescido de notícias de jornais do período, reunidos para contextualizar o empreendimento como uma resposta ao cenário político-sanitário nacional de então. Discute-se as condições urbano-sanitárias da cidade do Rio de Janeiro e identifica-se a relevância do descarte de lixo nas intervenções de melhoramentos urbanos, no período compreendido entre o final do século XIX e início do XX. Apresenta-se detalhes do funcionamento do complexo de incineração de lixo urbano municipal em Manguinhos, reconstruídos digitalmente com base em pesquisas arqueológicas e fontes históricas. Por fim, reflete-se sobre o motivo do desmonte do complexo de incineração e o destino desse território.
De la prostitución y sus enfermedades en México. Rupturas y continuidades (1862-1940).
Authors: Rodríguez Bravo Roxana
Published: September 2022

El siguiente trabajo muestra un breve recorrido sobre la reglamentación de la prostitución femenina y el tratamiento de las enfermedades venéreas en México que se asociaban al ejercicio de esta actividad por mujeres prostitutas. Desde el siglo XIX con las diversas políticas higienistas se aplicaron distintos tratamientos y medidas médicas que buscaban evitar la propagación de las enfermedades venéreas, siendo la sífilis el padecimiento contra el que más se lucho debido a su amplia transmisión en la población, sobre todo entre las prostitutas y sus usuarios. Dichas medidas y la experimentación de distintos medicamentos continuaron en México durante el periodo post revolucionario cuando se instauró una campaña federal contra las enfermedades venéreas y hasta el uso masivo de antibióticos que resultaron ser la cura más efectiva tanto para la sífilis como para otras enfermedades como la gonorrea.
Crisis y miedo: las fiebres de 1813 en Tlalnepantla, Estado de México
Authors: Mora Rebeca López
Published: September 2022

En este artículo se abordará la llegada de la epidemia de 1813 a Tlalnepantla y sus pueblos sujetos, mismos que se ubicaban en el camino hacia Querétaro. Como sucedió en otras zonas de la Nueva España, las llamadas “fiebres misteriosas” o “epidemia de fiebres” provocaron una catástrofe demográfica de grandes dimensiones. Se pretende demostrar que el paso de tropas por el camino hacia el norte fue un factor determinante para la llegada del tifo a esta zona. Las fuentes con que se contó para hacer este estudio son de dos tipos: la información generada por las autoridades militares leales a la Corona, que reflejaban su gran preocupación ante el aumento de los contagios en esta zona, y los archivos parroquiales de Tlalnepantla.
Conteúdos pedagógicos em mídias sociais
Authors: Marques Gutenberg de Lima
Published: September 2022

Este artigo entrelaça a área da educação musical e da pedagogia vocal com práticas pedagógicas que acontecem nas mídias sociais. O YouTube é compreendido enquanto uma mídia social de consumo e compartilhamento de vídeos. Desta forma, este trabalho buscou analisar as características e aspectos pedagógicos dos vídeos mais visualizados no YouTube para o ensino de canto. A abordagem metodológica baseou-se na pesquisa documental. Para compor o corpus, foram selecionados dez vídeos sobre o ensino de canto, com os maiores índices de visualização e oriundos de canais distintos. Em relação à análise dos vídeos investigados, notou-se o foco dos conteúdos em relação à técnica vocal, objetivando o aprimoramento da resistência e colocação vocal, sem estar necessariamente aplicadas à prática musical de repertórios. Também foi possível perceber que os conteúdos estão voltados para os elementos iniciais da prática do canto. Através deste trabalho, foi possível contribuir na compreensão dos conteúdos de vídeos publicados no YouTube, neste caso, os voltados ao ensino de canto.
Revelações do corpo
Authors: Hencke Jésica
Published: September 2022

Esse artigo se propõe a pensar o corpo humano composto por órgão, cartilagens, ossos, sua carnalidade, amparando nos estudos de Merleau-Ponty (1992, 1994, 2004), cuja intenção é apresentar uma síntese provisória do conceito de percepção. Fala-se acerca do processo de formação corporal e da experiência sensível que se mostra como propulsora à estesia. Acredita-se que o ser humano, em estado anestésico, vive num fluxo automático de ação-reação irrefletida e indiferente aos acontecimentos que modificam o seu meio cultural. Realiza-se algumas aproximações da temática corpo como potência de criação inebriada por fluxos, sensações e excreções, amparado na experiência estética. Neste contexto a estética não é balizada como uma vertente da filosofia que visa explicitar o belo, mas sim, enfoca a experiência que transforma, desestabiliza e produz sensações. Busca-se dirimir a dicotomia corpo e mente, a medida em que se acredita no corpo, como um elemento inseparável da sua história.
“Caminhos entre o gesto e o sonoro”
Authors: Resende Cecília de Ávila , Aparecida Mendes Mariana
Published: September 2022

“Caminhos entre o gesto e o sonoro” foi uma videodança produzida em 2020 entre discentes do curso de dança e música do Instituto de Artes da Universidade Federal de Uberlândia (IARTE-UFU), através de recursos do Festival EntreArtes Digital (2020). O trabalhou foi construído a partir de uma perspectiva híbrida, em que os materiais sonoros e gestuais foram explorados por ambas as artistas e tiveram o mesmo grau de importância. Devido ao contexto da pandemia de COVID-19, o trabalho foi feito à distância, sem que as artistas tivessem qualquer contato presencial. Esse artigo busca discutir as questões relacionadas à produção artística ‘entrearte’ e a criação coletiva no formato remoto, através do relato do processo de criação da obra.
Experiências artísticas em escola
Authors: Lopes Junqueira Mariana , Carvalho Carla
Published: September 2022

Ao cursar a licenciatura em Música, quem opta pela docência na Educação Básica, além de trazer a identidade de professor para a sala de aula, traz também a identidade de músico, visto que as duas estão imbricadas. Em um percurso de formação docente, faz-se necessário que os acadêmicos tenham liberdade para que essas identidades se manifestem quando estão atuando na escola. Neste artigo, temos um olhar voltado ao conceito de experiência de Larrosa (2016), a qual é aquela que nos acontece, que nos toca e que nos transforma. Este estudo caracteriza-se como qualitativo e tem como objetivo compreender como experiências artísticas em escola se relacionam e contribuem para a composição do músico-professor. Realizamos a investigação em uma universidade no estado de Santa Catarina, Brasil, com oito acadêmicos do curso de Música que participaram do Programa Institucional de Bolsa de Iniciação à Docência de Música. Analisamos portfólios reflexivos, conversa em grupo e letras de músicas compostas por esses acadêmicos. O fazer musical perpassou esse percurso de formação no subprojeto, permitindo que as identidades de músico e professor estivessem imbricadas nesse percurso de formação.
Imprensa, escrita feminina e práticas liberais democráticas na Paraíba na década de 1930
Authors: Silva Shirley Targino , Tristão Isabela Nathália Nunes
Published: September 2022

Este estudo tem como objetivo identificar e analisar os discursos sobre civismo e democracia que eram veiculados na Paraíba, na primeira metade do século 20, a partir dos periódicos Boletim de Educação, organizado pelo departamento de Estatística e Publicidade do Estado, e Periódico Educacional da Diretoria de Ensino Primário da Paraíba (Revista do Ensino), articulando com as propostas educacionais para o período em questão e destacando o papel das mulheres dentro do contexto de produção e divulgação da imprensa paraibana entre os anos de 1936 e 1937. Inicialmente, discorreremos brevemente sobre o uso de fontes documentais na História da Educação e a sua importância nos caminhos teórico-metodológicos escolhidos por pesquisadores(as). A partir disso, explanaremos sobre a atuação feminina na imprensa oficial e nas discussões políticas da Paraíba. Posteriormente, analisaremos as fontes já mencionadas, indicando os principais pontos de discussão sobre civismo e democracia – também estruturadas em uma pesquisa bibliográfica anteriormente feita. Tendo em vista os aspectos observados, é possível concluir que a escrita feminina forneceu contribuições históricas ao cenário social, educacional e político paraibano, objetivando a conquista de uma sociedade menos desigual, promovendo a equidade entres os gêneros e o avanço das práticas educacionais.
“pedagogia da indaga” e a construção de conhecimentos na extensão rural
Authors: Marinho Cristiane Moraes , Wizniewsky José Geraldo , Picolotto Everton Lazzaretti
Published: September 2022

Este trabalho discute as práticas extensionistas desenvolvidas pelo Instituto Regional da Pequena Agropecuária Apropriada (IRPAA), com o objetivo de analisar os fundamentos teórico-metodológicos que orientam as intervenções dessa organização junto a agricultores e agricultoras familiares no território Sertão do São Francisco, semiárido baiano. Com um aporte teórico-metodológico qualitativo, a pesquisa foi desenvolvida a partir de três processos metodológicos, inter-relacionados e complementares, sendo: a pesquisa bibliográfica, o levantamento em fontes primárias, e a entrevista semiestruturada, que privilegiaram a interação face a face com os sujeitos da pesquisa, sendo cinco agricultores/as, cinco técnicos/as extensionistas e dois coordenadores. A pesquisa evidenciou que as práticas desenvolvidas pelo IRPAA estão imbricadas com a própria sistematização, construção e compartilhamento da Convivência com o Semiárido. Nessa perspectiva, as intervenções realizadas pelo IRPAA fundamentam-se na própria trajetória histórica da organização, considerando sua emergência a partir das Comunidades Eclesiais de Base da Igreja Católica, da educação popular e do enfrentamento do paradigma de combate à seca. Partindo da escuta, do conhecimento da realidade, da problematização e da participação, os processos metodológicos empreendidos pela organização buscam superar a trajetória histórica brasileira da Assistência Técnica e Extensão Rural (ATER) em sua vertente antieducativa, antidialógica e difusionista.
Selection of promotional media with the integration of AHP Fuzzy and TOPSIS (case study in a study program)
Authors: Indrayana Masrul , Utomo Dutho Suh
Published: September 2022

Private universities need new students as one of the income to be able to run their operations. For that promotion needs to be done by them. When carrying out promotional activities, it is necessary to look at the availability of the budget, so it is necessary to be selective and choose the right promotional media and according to the budget. Selection of promotional media in addition to considering the budget, there are several criteria that must be considered, therefore the selection requires a multi-criteria method, one of which is TOPSIS. Initial weighting of the criteria for TOPSIS can be done with Fuzzy AHP, this method is used because it can overcome the fuzzy assesment when performing pairwise comparisons. So far, there are not many combined applications of Fuzzy AHP and TOPSIS in the selection of promotional media, so this research is expected to have a contribution to fill the gap. From the results of the study, it was found that the order of criteria that were important for the study program in the selection of promotional media were; cost, reach, audience fit and easy to apply. Meanwhile, the result of selecting the best promotional media for this study program was through social media
ANALYSIS AND DESIGN OF ERGONOMIC WORK POSTURE IN CUTTING PART IN PT XYZ USING REBA METHOD
Authors: Sepriandi Parningotan  , Isdaryanto Iskandar
Published: September 2022

Human activity requires a tool that is designed or specifically designed to help work to be easier, safer and more comfortable, the right design can be obtained by applying anthropometry. Workers often experience complaints of pain in some parts of the body because work facilities are not ergonomic. The research objective is to obtain an ergonomic design of work facilities in accordance with anthropometry. Data collection is done by interviews, distributing questionnaires and taking data on the object of research. The results of data collection were tested for uniformity, adequacy, and normality, as well as calculating percentiles that were considered to represent the measured data. SNQ results indicate that workers are in the very painful category in the right upper arm, waist, right ankle, left ankle, left knee, right knee, left calf, right calf, left foot and right foot, which shows the working posture at the cutting station not ergonomic. The assessment of the level of work posture using the REBA method shows a high risk level of 7-9 meaning that workers need immediate improvement in the near future. The average workload with the 42% CVL method is in the category of improvement needed. The proposed work facility design is based on anthropometric principles, namely a work desk measuring 171.75 cm x 78.5 cm x 70.45 cm, a work chair 46.99cm x 31.67 cm x 45.25 cm, a storage box of 50 cm length and width 55 cm and trolley 76.58 cm x 60 cm x 77.07 cm.
Total Productive Maintenance Analysis of The Oven Machine Using Overall Equipment Effectiveness Method
Authors: Azra Muhammad Azyumiardi , Dwijayanti Khusna
Published: September 2022

The oven machine is one of the important components of the production process in the bakery company. CV Halalan Thoyiban is a bakery company engaged in the manufacture of various breads. The products of this company are various bread such as Bakpia Green Bean and Bakpia Green Coconut. The problem that occurs in the company is the low efficiency of bakpia bread production, caused by the large number of machine breakdowns so that the optimal level of machine productivity is not achieved. The production machine, especially the oven machine often breaks down and causes the production process to stop. Based on these problems, in this study, an analysis of Total Productive Maintenance (TPM) was carried out using the Overall Equipment Effectiveness (OEE) method to measure the effectiveness of the machine. Further analysis of the cause-and-effect diagram is conducted to propose the improvement recommendation. The results of the analysis show the Overall Equipment Effectiveness (OEE) for the oven machine obtained an average of 38.1%, where the activity measured at the availability index is 59.72%, the performance index is 68.90% and the quality ratio is 93.30%. The OEE value is low and does not meet the World Class standard. The main causes are large breakdowns and long maintenance processes. The first improvement recommendation is applying preventive maintenance based on the planned maintenance schedule. The second recommendation is providing a training to operators about machine operation and maintenance. And the last is providing a simple installation for gas cylinder to avoid the long changing time to maximize performance of the oven machine.
Therapeutic Approach and Characterisation of Watermelon (Citrullus lanatus) Rind against Acrylamide Toxicity
Authors: Jha Namrata , Johri Dr. Sonia , Shrivastava Sadhana , Gupta Poonam , Yadav Kamini
Published: September 2022

Watermelon (Citrullus lanatus) is a cheap and easily available fruit in the local markets of India. The rind, which is the outer layer of watermelon, is completely edible. It is the only fruit with 90 per cent of water, and is fully edible including its rind and seeds as they contains different types of nutrients which are needed by our body in day to day life. The benefits in our body, includes reduced blood pressure, presence of different types of vitamins, such as vitamin A, B & C, as well as different types of minerals required by our body. The present study aims in evaluating the presence of different secondary metabolites in the watermelon rind. The therapeutic efficacy of watermelon rind against acrylamide toxicity in the lymphocyte cell line is studied. As selenium is an important micronutrient, an attempt has been made to prepare the selenium nanoparticles followed by its characterisation.
Gut Microbiome and COVID 19 Role of Probiotics on Gut Lung Axis
Authors: Kumari Manisha , Bhushan Brij , Sharma Dolly , Ganju Lilly , Varshney Rajeev , Meena Ramesh Chand
Published: September 2022

Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) has caused the greatest worldwide pandemic called Coronavirus-2019 (COVID-19) disease. The SARS-CoV-2 virus primarily attacks the respiratory tract, but it also disturbs the gastrointestinal system (GIT). The presence of the angiotensin-converting enzyme-2 (ACE-2) receptor in the intestinal epithelial cells, suggest the transmission of SARS-CoV-2 viruses from lungs to gut through systemic circulation. The virus detected in fecal samples of COVID-19 patients causes several gastrointestinal maladies including vomiting, diarrhea, and pain in abdomen. The gastrointestinal symptoms are associated with alterations in gut microbial composition, an increase in inflammatory cytokines and delayed virus clearance. Several studies demonstrated a decreased abundance of beneficial microbial species and increased opportunistic pathogens in the fecal samples of COVID-19 patients. The gut and lungs, share a bi-directional relationship called the “gut-lung axis” which is modulated by imbalanced gut microbiota. Since the gut microbes are suggested to play a vital role in health and disease by maintaining homeostasis of the immune system, therefore targeting the intestinal dysbiosis with beneficial microbial species, seems plausible to eventually diminish the effects of pulmonary infections and diseases. In this review, we have summarized studies demonstrating the gut-lung axis in association with gut dysbiosis in COVID-19 patients. In addition, the review also highlights the studies showing the potential role of probiotic supplementation in the amelioration of various respiratory infections and diseases. Data demonstrate that the restoration of gut microbial communities by probiotic supplementation can enhance lung capacity to combat respiratory viral infections including SARS-CoV-2.
Efectos para la salud respiratoria de los trabajadores que usan sustancias químicas en su medio laboral. Una revisión sistemática
Authors: Berena Pertuz Yolima , Rebolledo Castillo Maria Victoria , Vásquez Brochero Hamer Yamid , Gil Escamilla Maria José
Published: September 2022

Introducción: A nivel laboral se presentan muchas afecciones en la salud de los trabajadores debido a riesgos químicos a los que están expuestos diariamente a esto se suma la falta de compromiso de los empleadores con la salud de sus subordinados ya que éstos manejan diariamente sustancias químicas nocivas sin la debida protección personal. Objetivo: identificar los efectos nocivos para la salud respiratoria de los trabajadores expuestos en su área laboral a sustancias químicas. Metodología: Se realizo una revisión sistemática de la literatura, se consideraron artículos de investigación realizadas a partir del año 2014 hasta el año 2020. Las palabras claves fueron “Trabajadores” OR “Laboral” AND “Contaminantes” OR “Agentes” AND “Enfermedad reconocida” y se revisaron artículos de bases de datos como Google académico, SciELO (Scientific Electronic Library Online), ProQuest, Redalyc y Biblioteca Digital Universidad Cooperativa de Colombia. Conclusión: La salud de los trabajadores sin importar en qué área laboral se encuentren se ve afectada en varios aspectos los cuales pueden variar entre ellos se encuentran los sistemas respiratorios, el sistema reproductor, el sistema nervioso, el sistema tegumentario y el sistema gastrointestinal de forma crónica o aguda. Entre los agentes más comunes causantes de las enfermedades respiratorias se reportan los pesticidas, el plomo y solventes.
La sistematización de los riesgos en procedimientos estéticos invasivos
Authors: Vallejo Jiménez Geovana Andrea , Tamayo Palacio Ana Isabel
Published: September 2022

Introducción. La cirugía estética tiene un importante reconocimiento en la sociedad contemporánea. Colombia se ubica como uno de los países en el que anualmente se practica un alto número de procedimientos estéticos invasivos; sin embargo, también se ha establecido que esta especialidad presenta frecuentes complicaciones cuyos riesgos necesitan ser registrados y sistematizados. Objetivo. Proponer un modelo adicional de sistematización de riesgos en cirugía estética que fortalezca los comúnmente empleados en Colombia. Metodología. El método utilizado fue el de estrategias de prevención de riesgos aplicadas al ámbito médico, empleando para este trabajo las dos primeras etapas, es decir, la sistematización de fuentes de información a partir de datos obtenidos de la gaceta jurisprudencial publicada por el Tribunal Nacional de Ética Médica; y, la identificación de la taxonomía de los eventos y errores médicos en cirugía estética. Resultados. En total se analizaron 57 providencias de las gacetas del Tribunal Nacional de Ética Médica sobre cirugía plástica y estética (privilegiando los procedimientos estéticos invasivos), pertenecientes a los años 2012, 2015 y 2017, de estas 34 cumplieron los criterios de selección; posteriormente, se realizó la sistematización de los riesgos hallados. Conclusiones. El modelo de tecnovigilancia empleado en Colombia resulta insuficiente a la hora de registrar los eventos y errores que se producen en procedimientos estéticos invasivos, por lo que es necesario emplear métodos adicionales que permitan garantizar una mayor seguridad en el paciente, prevenir daños lesivos y disminuir los procesos judiciales en contra del personal sanitario.
Características y usabilidad de dispositivos de geolocalización en personas mayores: una revisión de alcance
Authors: Yáñez Yáñez Rodrigo , Cárdenas Miranda Henry , Maldonado Andrade Diego , Quiroz Quiroz Marcelo , McArdle Draguicevic Nelson , Cigarroa Cuevas Igor Iván
Published: September 2022

Introducción: Actualmente el desarrollo, aplicación y uso de las nuevas tecnologías vinculadas a la salud, es un campo emergente. En la actualidad no existe una revisión que sintetice la información sobre características y usabilidad de geolocalizadores en personas mayores. Objetivo: Sintetizar la evidencia existente sobre las características y usabilidad de dispositivos de geolocalización en personas mayores. Metodología: Se realizó la búsqueda de artículos científicos en las bases de datos: Medline vía PubMed, Lilacs y Google Scholar que cumplan con los criterios de elegibilidad, entre la fecha del 1 de agosto del 2018 hasta el 30 de noviembre del 2020, seleccionando 11 documentos. Para la identificación de artículos se utilizó las palabras clave “Geolocalizador”, “elderly”, “aged” y “older adults” Resultados: La edad promedio de las personas participantes,fue de 60,5, predominaron los estudios en género femenino, la población residía en su mayoría (63%) en la comunidad y el 36,6% padecían algún trastorno cognitivo. En cuanto a las características de los geolocalizadores el 72% de los dispositivos tiene un alcance de radio urbano y que el 54% tiene un costo bajo o gratuito en su implementación o ejecución. Conclusión: Esta revisión caracterizó los dispositivos de geolocalización y su uso en personas mayores en cuanto a su radio de alcance, costo, objetivos de intervención y población objetivo. Estos resultados podrían ser útiles para futuras investigaciones en el área de la gerontolocalización.
Environmental Uncertainty Factor, Incoterm and Implication For A Strategic Alliance In Freight Forwarder Companies Case Study In Indonesia
Authors: Sugiono Ahmad , Rahayu Agus , Wibowo Lili Adi
Published: September 2022

The study analyzes the effect of environmental uncertainty and incoterms on strategic alliances. The population in this study is a freight forwarder company on the island of Java that has a global alliance. The research sample is 50 companies engaged in international freight forwarders. Based on answers from respondents were analyzed according to the research model developed from the theoretical framework using the structural equation model Smart-PLS approach. The analysis results show that environmental uncertainty and Incoterm positively and significantly affect strategic alliances. The alliance strategy will impact when the main priority is the risk-sharing aspect, the risk management factor from the incoterm aspect, and the market turbulence on the environmental uncertainty factor. Novelty in this study is the positive impact of Incoterm on the alliance strategy, especially for International freight forwarders. This research contributes to the factors considered in strategic alliances in the freight forwarder industry. It also contributes to the company's strategy, especially sales managers, to pay attention to international trade terms in segmenting and selecting target consumers to be more effective in improving alliance performance. The limitations of this study include 1) The sample size used is only a small number of companies engaged in international Freight Forwarder services, only 50 companies; 2) The data used in this research is through the distribution of questionnaires based on perceptual analysis units; 3) Other factors that are outside the model are not all studied, while the possibility of these factors can affect the existing significance test.
Cybersecurity in the V4 Policy in 2011–2022
Authors: Górka Marek
Published: September 2022

The Visegrad Group (V4) is one of the most intriguing examples of cooperation among countries in Central Europe. It unites the Czech Republic, Hungary, Poland and Slovakia. Together, these countries form a useful framework which facilitates policy coordination at the regional level. They also implement EU agendas by creating networks of cooperation with neighbouring countries. These networks are based on the countries’ mutual security geography and a common strategic culture. When, in 2014, the most important political goals were achieved, there emerged a need to set a new direction for cooperation. It turned out that many issues in the field of public policy, such as transport infrastructure, natural environment, tourism, migration, culture or education, can be effectively implemented at the V4 level. Moreover, cooperation in a common cybersecurity policy is now a chance for deeper cooperation between the four countries. However, changes in the use and dissemination of cybertechnology in the public space began to gather momentum only in the first decade of the 21st century. Thus, the process of cyberrevolution was a harbinger of changes in state management. This study analyses the cybersecurity policy of the Visegrad Group countries from 2011–2022 from both military and non-military aspects.
Ewolucja przemówień Wołodymyra Zełenskiego jako prezydenta Ukrainy przed 24 lutego 2022 roku
Authors: Donaj Łukasz , Wochelski Marcin
Published: September 2022

Wybrany prawie trzy lata temu prezydent Ukrainy Wołodymyr Zełenski był początkowo postrzegany przez pryzmat swojej wcześniejszej kariery aktorskiej, co wpłynęło na brak szerszego zainteresowania treścią jego wystąpień. Zbrojna agresja Federacji Rosyjskiej na Ukrainę spowodowała skupienie uwagi świata na tym kraju oraz jego przywódcy tym bardziej, że zaczęto doceniać zdecydowanie i skuteczność podejmowanych działań. Celem artykułu jest analiza oficjalnych wystąpień prezydenta Wołodymyra Zełenskiego, w okresie od złożenia przysięgi przed Radą Najwyższą (20 maja 2019 r.), do rozpoczęcia agresji w dniu 24 lutego 2022 r. Na podstawie badania z użyciem metody analizy treści dowiedziono, że przemówienia prezydenta cechują się konsekwencją przekazu i naciskiem na zrozumiałość formy, a w zakresie treści, obok wątków odwołujących się do dziedzictwa narodowego i aktualnej sytuacji społeczno-politycznej, akcentują budowę nowoczesnego, demokratycznego społeczeństwa.
Propofol ameliorates ischemic brain injury by blocking TLR4 pathway in mice
Authors: Mitsui Kazuha , Kotoda Masakazu , Hishiyama Sohei , Takamino Ayasa , Morikawa Sho , Ishiyama Tadahiko , Matsukawa Takashi
Published: September 2022

Ischemic brain injury is one of the most serious perioperative complications. However, effective preventative methods have not yet been established. This study aimed to investigate whether propofol has neuroprotective effects against ischemic brain injury, with a specific focus on Toll-like receptor 4 (TLR4). Focal brain ischemia was induced via a combination of left common carotid artery occlusion and distal left middle cerebral artery coagulation in mice. Either propofol (10 mg/kg) or vehicle was intravenously injected 10 min prior to the induction of brain ischemia in wild-type and TLR4 knockout mice. Infarct volume, pro-inflammatory cytokine expression, inflammatory cell infiltration, and neurobehavioral function were assessed. Propofol administration significantly reduced infarct volume in wild-type mice (26.9 ± 2.7 vs 15.7 ± 2.0 mm3 at day 7), but not in TLR4 knockout mice. Compared with the control mice, the propofol-treated wild-type mice exhibited lower levels of IL-6 (0.57 ± 0.23 vs 1.00 ± 0.39 at 24 h), and smaller numbers of TLR4-expressing microglia in the penumbra (11.7 ± 3.1 vs 25.1 ± 4.7 cells/0.1 mm2). In conclusion, propofol administration prior to ischemic brain insult attenuated brain injury by blocking the TLR4-dependent pathway and suppressing pro-inflammatory cytokine production.
Psychodynamic Psychiatry in Singapore
Authors: Teo David Choon Liang , Wuan Eugene Kin Mun , Lee Dawn Sue-Fern , Tay Andre Teck Sng , Cheng Samuel Eng Teck
Published: September 2022

The authors provide an overview of the history of psychiatric services and training in Singapore, and the more recent introduction of psychodynamic psychotherapy training for psychiatric residents. They describe the current state of psychodynamic psychiatry services in the public healthcare system, including efforts at fostering psychodynamic thinking in nonpsychiatric community partners via community mental health integrated care programs and activities such as Balint Groups. They discuss current challenges in psychodynamic practice, such as the impact of language and culture on the Singaporean individual's receptiveness to psychodynamic psychotherapy, as well as systemic challenges in funding and expanding psychodynamic services. They highlight future directions, including challenges and opportunities for the local psychodynamic community in Singapore.
Some Clinical Contributions of Jacques Lacan
Authors: Perman Gerald P.
Published: September 2022

Jacques Lacan was a French psychiatrist and psychoanalyst who created an original metapsychology based on a close reading of the work of Sigmund Freud combined with the structural linguistics of Ferdinand de Saussure. Lacan's concept of the unconscious is that of a highly structured entity consisting of interlacing chains of signifiers (sounds, printed words, and images) based on principles of metaphor and metonymy. In this review article, the author provides a brief biographical summary of Lacan's formative years, his education, and his career, followed by a discussion of some of his major theoretical concepts. Lacan's three registers or orders of existence, the Imaginary, the Symbolic and the Real, and their relationship to normal and psychopathological mental functioning are described. Lacan's major structural diagnostic categories are defined as well as his proposed etiology for the development of each of them. Lacan's formulation of need, demand, and desire are described as well as his late concept of le sinthome. Brief clinical vignettes are used to illustrate some of Lacan's theoretical concepts, and some clinical recommendations are provided. Lacan's theories and practice were controversial over his almost 50-year career, and his work is largely unknown to psychiatrists and psychoanalysts in the United States. This article is an effort to fill a small part of this lacuna.
MEMÓRIAS AFETIVAS DA INFÂNCIA E SEU IMPACTO NA FORMAÇÃO DO TURISTA
Authors: Cristina Vidal da Rocha Mirian , Eduardo Oliveira Amaral Bezerra Franklin , Alan Deslandes Fragoso Paulo , Luís Faria Duarte André
Published: September 2022

O presente trabalho investigou o impacto de viagens vivenciadas na infância, para, assim, verificar se tal experiência contribuiu para o desenvolvimento do gosto de viajar futuro e, consequentemente, formar um turista a partir de tal vivência. Desse modo, este estudo teve como objetivo principal identificar o papel da memória nesse processo de formação do turista. Este estudo justifica-se pelo importante entrelaçamento entre a memória e o turismo, visto que a experiência turística está vinculada, também, à memória afetiva. Para cumprir as finalidades deste estudo, foi utilizado um questionário, no formato online, a partir da plataforma do Google Forms, disponibilizada de 20 de abril de 2021 até 20 de maio de 2021, contendo perguntas abertas e fechadas. Ao se debruçar na análise dos dados da pesquisa, verificou-se que a memória afetiva teve impacto significativo no desenvolvimento do gosto por viajar. Sendo assim, este estudo caracteriza-se, dentro do campo do turismo, como uma reflexão importante no que se refere ao desenvolvimento de estratégias voltadas para o público infantil.