bluuebunny/crossref_metadata_2025 huggingface dataset:
Novel β-cyclodextrin doped carbon dots for host–guest recognition-assisted sensing of isoniazid and cell imaging
Authors: Li Lu-Shuang , Zhang Ying-Xia , Gong Wei , Li Jing
Published: October 2022

Novel β-cyclodextrin (β-CD) doped carbon dots (CCDs) were prepared at a mild temperature to preserve the host–guest recognition properties of β-CD. An isoniazid fluorescence sensor was constructed with a limit of detection of 0.14 μg mL−1.
Dual-emissive ratiometric fluorescent nanosensor based on multi-nanomaterials for Ag+ determination in lake water
Authors: Zhu Ling , Shi Lujia , Tan Yiping , Zhang Huaiyin , Yin Jiacheng , Xu Chang , Wu Danlian , Ma Yunsu
Published: October 2022

A novel ratiometric fluorescent sensor (CDs/CdTe QDs@ZIF-8) combining the advantages of ratiometric and MOFs was synthesized for Ag+ detection.
Mechanical and thermal properties of carbon nanotubes in carbon nanotube fibers under tension–torsion loading
Authors: Niu Mowen , Cui Chongxiao , Tian Rui , Zhao Yushun , Miao Linlin , Hao Weizhe , Li Jiaxuan , Sui Chao , He Xiaodong , Wang Chao
Published: October 2022

Systematically investigate the mechanical and thermal properties of SWCNT under tension and torsion loadings and provide references for fabricating next-generation super-CNF.
Cell chirality exhibition of brain microvascular endothelial cells is dependent on micropattern width
Authors: Porras Hernández Ana María , Tenje Maria , Antfolk Maria
Published: October 2022

Brain endothelial microvascular cell chirality is dependent on micropattern width and spatial localization. Finding the optimal micropattern width and including only the centre cells in the analysis for chirality-based experiments might improve further experimental results.
Self-biased photodetector using 2D layered bismuth triiodide (BiI3) prepared using the spin coating method
Authors: Punde Ashvini L. , Shah Shruti P. , Hase Yogesh V. , Waghmare Ashish D. , Shinde Pratibha S. , Bade Bharat R. , Pathan Habib M. , Prasad Mohit , Patole Shashikant P. , Jadkar Sandesh
Published: October 2022

Layered bismuth triiodide (BiI3) is a 2D material that has emerged as an ideal choice for optical sensors.
Application of orthogonal metal–ligand interactions for the synthesis of interpenetrating metallopolymer networks featuring shape-memory and self-healing abilities
Authors: Meurer Josefine , Bätz Thomas , Hniopek Julian , Bernt Carolin , Zechel Stefan , Schmitt Michael , Popp Jürgen , Hager Martin D. , Schubert Ulrich S.
Published: October 2022

This study presents interpenetrating metallopolymer networks (IPNs) based on the orthogonality of two different metal complexes. The synthesized IPNs exhibit excellent shape-memory and self-healing abilities.
Modulating liquid–liquid phase separation of FUS: mechanisms and strategies
Authors: Ji Yanglimin , Li Fen , Qiao Yan
Published: October 2022

This review summarizes the regulations of liquid–liquid phase separation involving fused in sarcoma protein (FUS) by physical stimuli, biochemical modulators and protein structural modifications.
Photovoltaic memristors based on photoelectric synaptic plasticity of a bulk photovoltaic effect device
Authors: Chen Yang , Wei Haoming , Wu Yangqing , Yang Tengzhou , Cao Bingqiang
Published: October 2022

As devices with plasticity similar to biological synapses, photovoltaic memristors based on the bulk photovoltaic effect exhibit impressive abilities for autonomous learning and memory.
Neurological Complications in Benign Parapharyngeal Space Tumors – Systematic Review and Meta-Analysis
Authors: Faisal Muhammad , Seemann Rudolf , Fischer Gregor , Lill Claudia , Hamzavi Sasan , Wutzl Arno , Erovic Boban M.
Published: October 2022

Introduction Parapharyngeal space tumors with complex anatomy and diverse histology have remained a challenging phenomenon for treating physicians.

Objectives We have conducted a comprehensive web search on the PubMed, Web of Science, EMBASE, Cochrane Library, Biomedical Literature Database (CBM), and Clinicaltrials.gov databases to determine the factors that are associated with postoperative complications in parapharyngeal space tumors.

Data Synthesis Two researchers reviewed all identified articles independently with a third reviewer for adjudication. Patient demographics and other clinicopathological characteristics were explored. The systematic review has identified 631 benign parapharyngeal space tumors with neurogenic and salivary tissue histology in 13 studies, with a mean age of 42.9 ± 7.76 years old and a median follow-up of 40.98 ± 19.1 months. Salivary gland (50.8%) and neurogenic (49.1%) tumors were the most common histological entities. Tumor size, location, histology, deep parotid lobe involvement, and proximity to great vessels or to the skull base were the deciding factors in selecting the surgical approach. The factors considered to select the surgical approach do not seem to have a correlation with the outcome in terms of neurological sequalae (p = 0.106). Tumors with neurogenic histology have significantly increased chances of developing neurological complication (OR 6.07; p = 0.001).

Conclusion Neurologic complications are significantly associated with neurogenic benign tumors rather than surgical approach.
Simulation and optimization of spectral parameters of resonant optical gyroscope
Authors: An Panlong , Zhao Ruijuan , Liu Yaoying
Published: October 2022

As a new inertial navigation device, the resonant optical gyroscope offers advantages that include high precision, device integration, impact resistance, and solid-state realization. This device will be widely used in future military and civil applications. Following consideration of the factors that affect accuracy improvement of resonant fiber optic gyroscopes, the relationships among the insertion loss, coupling coefficient, and unit length loss of the cavity fiber and the resonance depth, full width at half maximum, and fineness of the transmission spectrum line are analyzed. To improve the transmission spectrum’s resonance depth, the coupling coefficient should be controlled at 0.2 and the optical coupler insertion loss should be reduced as far as possible. Additionally, the laser linewidth effects on the transmission spectrum and the limit sensitivity are analyzed. It is found that if the laser linewidth of the resonant optical gyroscope is less than 100 kHz, it can meet the resonance depth requirements, thus, providing a technical reference for further research into integrated optical waveguide gyroscopes.
A spatial model of conceptualization of time
Authors: Mkhitaryan Yelena , Madatyan Lusine
Published: October 2022

This paper presents a cognitive study of the lexical means of conceptualization of time in English and Armenian
fairy tales, and outlines the ways in which such conceptualizations are expressed in both languages. A spatial model for the
conceptualization of time is introduced, which helps reveal the complexities of lexical expressions of time in these fairy tale
texts. The model is depicted by geometric delineations and comprises the schemas which best conform to the folkloristic genre; the
depictions consist of a set comprising: point, interval, line, cycle, circle, and segment of a circle. A comparative analysis
between the languages reveals that each of these schemas is represented in both languages but to differing extents. Lexically, the
schemas are primarily expressed in English by noun phrases paired with prepositions, and in Armenian by prepositions or
postpositions or their morphological synonyms. Other means of schema expression in both languages include, with slight
differences, number markers, adverbs, adjectives, conjunctions, and deictics.
Extracts of Kecombrang Fruit (Etlingera elatior) Decrease NF-kB in Mus musculus Sepsis Model
Authors: Nurhayatun Evi , Ayuningdyah Chitra B
Published: October 2022

Sepsis is the consequence of widespread inflammation in the body. Inflammation and blood clotting during sepsis cause reduced blood flow to vital organs which can lead to organ failure and even death. Kecombrang (Etlingera elatior) is proposed to have the ability to suppress inflammation and oxidative stress through the control of NF-kB. This study aims to investigate the effect of the extract of Kecombrang fruit on the level of NF-kB in Mus musculus sepsis model. This laboratory experimental study was conducted on a total of 20 Mus musculus which were equally divided into four groups. Group received lipopolysaccharide (LPS) induction as the control group. MP1 group received LPS induction and pretreated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) for 5 days before induction of LPS. MP2 Group received LPS induction and treated with methanol extract of Kecombrang fruit (4.2 mg/20 gr) for 5 days after induction of LPS. MP3 group received LPS induction and treated with methanol extracts of Kecombrang fruit (4.2 mg/20 gr) at the same time of LPS induction. The measured outcome was the serum level of NF-kB. Data were analyzed using ANOVA with p <0.05. Pretreated extracts of Kecombrang fruit significantly decrease the serum levels of NF-kB (p<0.05). The beneficial effects of extracts of Kecombrang fruit in sepsis are evident from the observations. It means that the extract of Kecombrang can be exploited in the treatment of sepsis.
Greenhouse Gas Analysis in Field Maize Agriculture Using Life Cycle Assessment
Authors: Darmawan Muhammad Indra , Ilmannafian Adzani Ghani , Kiptiah Mariatul
Published: October 2022

The scope of this research was limited to analyzing land preparation and harvested maize. This study aimed to identify and measure the largest GHG in each process of field maize farming to design efficient mitigation efforts. This research employed a field research method and involved five farmer groups with different field maize farming models. The data analysis referred to the SNI ISO 14040: 2016 Framework, consisting of four stages: goal and scope definition, life cycle inventory analysis, life cycle impact assessment, and life cycle interpretation. The life cycle inventory used energy coefficients, emission factors, and the Intergovernmental Panel Climate Change (IPCC) guidelines. The results showed that the Total Global Warming Potential (GWP 100) in one ton of shelled maize production was 251.50–10,000.29 CO2 eq. The largest GWP was found in biomass burning and the use of Urea and NPK fertilizers. The potential for burning biomass was 5,533.67–9,683.93 CO2 eq per ton of shelled maize. There are two recommended efforts to minimize GHG emissions: converting biomass into feed and using organic fertilizer to reduce GWP from the use of fertilizer.
Design And Development of Coconut Husk Extraction Machine
Authors: Putera Perdana , Herdian Fithra , Novita Sri Aulia , Ernita Yuni , Makky Muhammad , Cherie Dinah
Published: October 2022

Coconut husk as by-product of coconut is very potential material for many applications. The coconut coir consists of coconut fibre and cocopeat. The improvement made in this research is to design a machine that suits the need of local coconut industry in Sumatera Barat. This machine is powered by 22 HP engine diesel that rotates at 1100 RPM. This engine is connected to rotary knife through double pulley-belt transmission system. The pulleys have 14:25 ratio with the lower side being installed to the engine and the other to the axis. There were 19 knives put to the axis with angle difference of 60 degree. This rotary knife was perpendicular to the axis to increase the effectiveness during the ripping process. The separation mechanism was done by using lines and holes in the cylindrical tube of the machine. The tube has diameter 596 mm. The capacity derived was 123 kg/hour. Dimension of the machine is 2270 x 900 x 1323.13 mm. This machine works for separating coconut fibre and cocopeat.
Effects Of Indigofera Zollingeriana As Substitute For Concentrate In Elephant Grass-Based Rations (Pennisetum Purpureum) On Availability Of Macro Minerals (Ca, P, Mg, & S) In Kacang Goat
Authors: Evitayani  , Warly L. , Yani D. , Rafiqa N.
Published: October 2022

This study aims to explore the best level of Indigofera zollingeriana as concentrate substitution in elephant grass-based rations on the availability of macro minerals (Ca, P, Mg, and S) in kacang goats. This study investigated 12 kacang goats weighing 11 to 12 kg were investigated. The data were collected using an experimental method with a completely randomized design (CRD), consisting of three treatments and four replications. They were P1: 60% elephant grass + 30% concentrates + 10% Indigofera zollingeriana; P2: 60% elephant grass + 20% concentrates + 20% Indigofera zollingeriana; and P3: 60% elephant grass + 10% concentrates + 30% Indigofera zollingeriana. The observed variables were the availability of calcium (Ca), phosphorus (P), magnesium (Mg), and sulfur (S). The statistical analysis used was the analysis of variance. Meanwhile, the mean differences were tested using the DMRT test (Duncan’s multiple range test). The results showed that substitution for concentrates with Indigofera zollingeriana significantly affects (P0.05) the availability of Mg and S minerals. This study concludes that the concentrate substitution with 30% Indigofera zollingeriana could increase the availability of calcium (Ca) and phosphorus (P) minerals, but not affect the availability of magnesium (Mg) and sulfur (S) minerals.
Genetic diversity of chili pepper mutant (Capsicum frutescens L.) resulted from gamma-ray radiation
Authors: Arumingtyas E L , Ahyar A N
Published: October 2022

Genetic variation is an important source for plant breeding activities. Efforts to develop genetic variation are among others carried out by mutation techniques including mutation induction with gamma-ray radiation. The purpose of this study was to analyze the genetic diversity of chili pepper as a result of mutation induced by gamma-ray radiation based on morphological characters, capsaicin content, and RAPD profile. Chili pepper seeds genotype G1 were irradiated with two doses of gamma-ray 200 and 400 Gy. Analysis of morphological characters refers to the descriptor Capsicum spp. The capsaicin content of the fruit was measured using a spectrophotometric method. Genetic diversity was analyzed through profiling and scoring of RAPD DNA bands represented in the form of a UPGMA dendrogram using the NTSYS 2.10e program. Statistical analysis of quantitative morphological characters and capsaicin content were conducted using SPSS 24.0 program. Gamma-ray radiation can induce variations in morphological characters. The radiation dose of 400 Gy was more effective in producing mutant variants with the highest characters of plant height, canopy width, stem diameter, fruit length, and number of fruits. Gamma-ray radiation did not significantly increase the capsaicin content of the fruit (P 0.05). Mutant G1 chili pepper showed morphological and molecular variations. The mutant group separated from the control showed that the mutants experienced a significant change in several characters.
The Effect of Petai (Parkia Speciosa Hassk) Seed Extract and Glimepiride on Blood Sugar Levels Of Alloxan-Induced Mice (Mus Musculus)
Authors: Alioes Yustini , Zain Eriza Amalia , Rofinda Zelly Dia
Published: October 2022

Diabetes mellitus is a metabolic disease characterized by hyperglycemia as a result of insulin deficiency in the body, ineffective insulin function, or both. Glimepiride is a third generation of oral hypoglycemic drug (OHO) that has a lower risk of hypoglycemia and weight gain compared to the first generation of sulfonylurea. Petai plant (Parkia speciosa Hassk) is one of the medicinal plants that has been known to be efficacious as antioxidant and anti-diabetic. This study aimed to discover the effect of administering the seeds of petai (Parkia speciosa Hassk) on blood glucose levels in mice induced by alloxan. This experimental study used 42 mice divided into 5 groups, they were K- (a standard diet), K+ (alloxan 175 mg/kgBB), control treatments P1 and P2 with doses of 300 mg/kgBB and 400 mg/kgBB of petai seed extract, and control treatment P3 with Glimepiride 0.0026/20g. This research was conducted at Pharmacology Laboratory of the Faculty of Pharmacy and Biochemistry of the Faculty of Medicine, Andalas University. Blood sugar levels were measured by the colorimetric method using vitalab micro spectrophotometer (Microlab 300). The results of the Kruskal-Wallis test on the blood sugar levels of mice with the administration of petai seed extract at a dose of 300mg/KgBB with a mean decrease in blood sugar levels of 85.48±5.32 mg/dl and on the blood sugar levels of mice with the administration of Glimepiride 0.0026mg/20gBB with a mean decrease in blood sugar levels of 88.73±9.95 mg/dl for 7 days did not show a statistically significant difference in the Post Hoc Test with Mann-Whitney (p = 0.423) with a mean difference of reduction of 3.25mg/dl. The conclusion of this study is that the petai seed extract has the same effective effect as Glimepiride to reduce blood sugar levels in alloxan-induced mice.
Molecular Dynamics Study of CO2/H2 and CH4/H2 Gas Separation by Nanoporous Graphene
Authors: Rivero R , Ren Y
Published: October 2022

The combustion of coal produces CO2 emissions, rising greenhouse gas levels, and leading to global warming. Hydrogen is one potential clean source of energy. However, current hydrogen production methods produce CO and CO2 emissions, while pure hydrogen is required for fuel cells. Therefore, efficient methods for capturing greenhouse gases and the extraction of pure hydrogen are required. Membrane gas separation requires low energy and cost. However, current polymer-based membranes struggle with the trade-off between selectivity and permeability. Graphene-based membranes like nanoporous graphene (NPG) are potential candidates due to its monoatomic thickness and high mechanical performance, offering high permeability. Selectivity was altered by controlling the nanopore shape, size, and functionality, and using multi-layered NPG with various interlayer spacing and angle. Molecular dynamics simulations were performed to study the transport phenomena for graphene-based membrane gas separation. CO2/H2 and CH4/H2 gas mixtures separation were performed on a bottom-up synthesized H-Passivated NPG with Dumbbell-Shaped Nanopores. Results show that 100% H2 selectivity was achieved for both CH4/H2 and CO2/H2 gas mixtures, using single layer NPG and tri-layer NPG, respectively, while maintaining high permeability in the order of 105-106 GPU. Therefore, the H-Passivated NPG with Dumbbell-Shaped Nanopores is an excellent choice of membrane for gas separation.
Terephthalic Acid (TPA) Recovery from Plastic Bottle of Polyethylene Terephthalate (PET) through Hydrolysis Treatment
Authors: Alias S , Abdul-Hakim N A
Published: October 2022

Recovery of plastic waste has a positive influence on solid waste management as it can bring new life to plastic waste. Hydrolysis treatment is one of the approaches for plastic waste recovery, in which plastic monomer can be recovered through depolymerisation. This study explored the recovery of polyethylene terephthalate (PET) plastic in nitric acid and leachate. The weight changes were analysed in PET when exposed to different hydrolysis agents (nitric acid and leachate) at different reaction times and temperatures. The monomer recovery of PET, known as terephthalic acid (TPA), was also evaluated. It was found that high temperatures and reaction times promoted to the high recovery of TPA. The PET residue measured as weight difference was found in line with the trend of TPA yield. The hydrolysis using nitric acid can recover more TPA than the leachate system. The knowledge obtained from this study would be beneficial in upcycling plastic waste into high-value end products.
Simulation of acid gas removal unit using DIPA+TEA amine solvent
Authors: Farooqi A S , Ramli R M , Lock S S M , Hussein N , Farooqi A S , Wajahat S M
Published: October 2022

Due to the inexpensive cost of amine solvent, more than 95 % of natural gas (NG) processing plants use an acid gas removal unit that utilizes an aqueous amine solvent to remove sour gas components such as carbon dioxide (CO2) and hydrogen sulfide (H2S). Different technologies are available to capture CO2 from NG. However, chemical absorption is the most reliable and used technology all over the world. However, it is challenging to determine the amine blend’s optimal composition for the effective removal of CO2 and H2S and solvent regeneration. This is mainly due to the difference in reservoir gas compositions, affecting gas removal efficiency and solvent regeneration energies. The present investigation addresses the performance of using a novel solvent blend of diisopropanolamine (DIPA) and Triethanolamine (TEA) to determine the absorption capacity of CO2 & H2S using Aspen HYSYS software. A study on the effects of solubility on CO2 absorption was performed at varying pressure (10-80 bar) and temperature (25°C to 50°C). The percentage of CO2 removal increased from 80% to 98% as the temperature increased from 25°C to 50°C. The results revealed that the concentration of CO2 and H2S in sweet gas decrease with the increase in pressure while the concentration of CO2 and H2S increases with the increase in temperature.
Quality prediction for polypropylene extrusion based on neural networks
Authors: Tan C H , Yusof K M , Alwi S R W
Published: October 2022

In the polypropylene (PP) industry, melt index (MI) is considered the most important quality variable. Different grades of PP have their specific range of MI. Accurate prediction of MI is essential for efficient monitoring and off-grade reduction. Neural Networks (NN) modelling is proposed as the technique for MI estimation. It has powerful adaptive capabilities in response to nonlinear behaviours. By training the NN, it can discover the relationship between inputs and outputs and makes it capable of function approximation. The goal of this research is to develop NN model to predict the MI based on PP extrusion parameters. Different types of NN such as artificial neural networks (ANN), stacked neural networks (SNN) and deep neural networks were trained and compared to understand their efficiency in solving the problem. The simulation results show that deep neural networks can perform the highest accuracy prediction with the lowest root mean square error (RMSE), followed by SNN and ANN. All three modelling proved that NN can perform non-linear function approximation for polymer extrusion.
Synthesis of zinc oxide derived from wastewater of glove manufacturing via adsorption-desorption-precipitation path
Authors: Pang C Y , Gulnaziya I , Pang Y L , Wong M C
Published: October 2022

The demand for ZnO significantly increased over the past decades. Extraction and refinement of zinc ores results in the release of hazardous wastes to the environment. In particular, the tremendous demand for disposable nitrile gloves during the Covid-19 pandemic has spiked superior demand for ZnO used as a crosslinking agent in the manufacturing process and leads to the generation of zinc containing wastewater traditionally removed via chemical precipitation. This paper focuses on the application of adsorption for zinc removal which opens an opportunity to recycle zinc to synthesize secondary zinc oxide. This study evaluated the feasibility of zinc oxide synthesis via the adsorption-desorption-chemical precipitation pathway. Palm shell activated carbon (PSAC), a low-cost adsorbent, was used for the removal of zinc from the synthetic and industrial wastewaters. Subsequently, zinc desorption was carried out using 0.3 M HCl. Then ZnO was synthesized from the desorption solutions via chemical precipitation using potassium hydroxide. Average zinc conversion rate of 98 % was achieved in this study. The synthesized ZnO exhibited high surface area of 97.4 m2/g after calcination (400 °C, 3 hr), high purity and crystallinity. The results confirmed the feasibility of zinc ions recovery for recycling to produce secondary good quality zinc oxide.
Investigation of fluid capillary rise using 3D printed microstructure for solar desalination
Authors: Ng R B , Hoo C L , Wong V L
Published: October 2022

Current desalination technologies such as thermal desalination and reverse osmosis are a process of converting seawater to freshwater. This method brings a negative impact on the environment such as CO2 emission. Solar desalination is one of the ways to resolve the current desalination challenges and more sustainable in terms of economic and environmental. Solar desalination uses solar energy as its energy consumption for evaporation. Solar desalination depends on the rate of evaporation specifically on the surface area. Hence, this study adopts the concept of cellular fluidics and 3D printing to perform capillaries rise and improve the liquid to the gas-surface area. The increase in strut diameter of the cell from 0.2 mm to 0.4 mm results in an increase of capillaries rise from 3.01 to 7.67 for Body Centered Cubic (BCC) cell geometrical shape. Different cell geometrical shape is also investigated with the strut diameter remaining constant. The Isotruss cell geometrical shape recorded a value of capillaries rise of 11.76 among the other geometrical shape due to Isotruss having more complexity in design and having internal structure.
Synergistic adsorption-photocatalytic degradation of Rhodamine B dye using a 3D-printed photoreactor with g-CN homojunction-based thermosets coating: response surface methodology and adsorption modelling
Authors: Lee EY , Wong SY , Wong VL , Phang SJ , Cheah KH
Published: October 2022

In present work, graphitic carbon nitride (g-CN) homojunction were synthesized to investigate the synergistic effect of photocatalysis and adsorption on Rhodamine B (RhB) dye degradation. The photodegradation (DE%) and adsorption (R%) were evaluated under the irradiation of two 50 W LED lights and in dark for 6 hours, respectively. A three-level Box-Behnken design (BBD) were employed to study the effects of initial dye concentrations (5 to 20 ppm), recirculation flow rates (1 to 3 mL/min), and the number of photoreactors (2 to 6) with total 15 sets of experiment. A quadratic regression was developed to predict DE% with an error of less than 5.5% relative to the experimental data. Additionally, ANOVA analysis showed that the number of photoreactors is the most influential parameter (p<0.05); while the two-way interaction between variables are insignificant. For the adsorption studies, Langmuir isotherm showed the best-fit result (R2>0.98) and the separation factor (RL) has indicated the adsorption process is favourable (RL=0.05). Additionally, the adsorption experimental data fit well with the pseudo-second-order kinetic model (R2>0.98). Overall, the development of homojunction photocatalyst has provided an innovative and alternative approach for water remediation.
Hydrothermal conversion of model polluted soil into zeolite P to in-situ immobilize heavy metals via zeolitization and its microstructure behavior
Authors: Miao Jiajun , Zhang Yafei , Yue Liang , Ran Xianqiang , Cheng Mingzhao , Jing Zhenzi
Published: October 2022

To develop a new technology to remediate pollution sites stably and effectively, hydrothermal conversion of polluted soil (model soil) into zeolite P for in situ immobilization of Heavy Metals (HM) was carried out. Zeolite P could be synthesized from soil hydrothermally with a large range of Al/Si ratio (0.33–1.0) in 48 h at 200 °C. With immobilizing heavy metals (Cr, Zn and Cd), the crystallization of Zeolite P (Cr-ZP, Zn-ZP and Cd-ZP) was delayed with the order of Cr >Zn >Cd because the stronger the ligand effect of heavy metals have, the more heavily the nucleation and growth were influenced. During immobilization via zeolitization, a self-adaptive structuring behavior was confirmed by EDAX, BET and Rietveld refinement analyses: zeolite P structured more [AlO4]− to immobilize HM because the flexible 8-member-Ring channels (8 mRs) with higher Al/Si ratio could complex with more HM readily. The encapsulated HM occupied the original Na positions (Na1 and Na2) of zeolite P competitively because of their different cation size, e.g., the smallest Cr3+ could substitute all Na1 because Na1 is closer to the Framework Oxygen (FO); the largest Cd2+, however, substituted Na1 (9%) and Na2 (14%) evenly. The shrunken 8 mRs due to heavy metal immobilization also caused different chemical environments for different heavy metals immobilized because the smaller heavy metal cation could get closer to the framework, and also coordinated with more FO.
Adsorption mechanism of basic blue-9 onto quartz mineral: kinetics, isotherms and thermodynamic
Authors: Labidi Nouar Sofiane , Mechati Boukoffa
Published: October 2022

Adsorption of basic blue-9 (BB9) by natural quartz mineral was tested. The quartz mineral was characterized by FTIR, SEM, DRX, zeta potential and Sear’s surface area measurements. The quartz mineral contains 99.13% of SiO2 and has a specific surface area of 0.6 m2g−1. The zeta potential measurements of quartz showed a zero point charge (ZPC) at a pH of 2.12. Adsorption experiments results of basic blue-9 showed an excellent achievement after 15 min, for 100 μm sorbent particles seize, 1.0 g l−1 sorbent mass, pH of 5.0, agitation speed of 200 rpm and Temperature of 60 °C. Moreover, the BB9 concentration and temperature were directly related to increase in adsorption capacity and the highest adsorption capacity of 27.78 mg g−1 was achieved for 30 mg l−1 at 60 °C. Langmuir isotherm and pseudo-second-order kinetics (R2 > 0.99) were found to be the most appropriate models to describe the removal of metylen blue dye by quartz mineral. The apparent diffusion parametres were estimated to be between 3.24 × 10–6 and 3.67 × 10–6 cm2 s−1, indicating an adsorption process controlled by the external mass transfert on the quartz surface. The calculated thermodynamic parameters and Dubinin–Radushkevich adsorption free energy (Eads = 0.28 kJmol−1) showed that adsorption of BB9 onto quartz was spontaneous, endothermic and a physisorption reaction. FTIR spectroscopy and semi empirical RM1 calculations established an adsorption mecanism by electrostatic attraction. The regeneration tests after four runs showed that natural quartz could be an alternative material for cationic dyes removal.
Efficacy of Percutaneous Superficial Temporal Arterial Hyaluronidase Injection for Hyaluronic Acid Filler–Induced Necrosis of Frontotemporal Skin and/or the Ipsilateral Scalp With Subsequent Alopecia
Authors: Zheng Can , Fu Qiang , Zhou Gui-wen , Xu Xiao , Tian Xiao-ming , Lai Lin-ying , Wu Qian , Ding Hong-fan , Yu Bo-ya , Chen Min-liang
Published: October 2022

Background

Necrosis of frontotemporal skin and/or the ipsilateral scalp with subsequent alopecia after hyaluronic acid (HA) filler injection into the temple is rare complications with superficial temporal artery embolization are suspected as the major pathological mechanism. The main treatment currently is intralesional hyaluronidase (HAase) injection, but the effectiveness of percutaneous superficial temporal arterial HAase injection still lacks consensus.

Objectives

To investigate the effectiveness of superficial temporal arterial HAase injection in dissolving HA filler–induced necrosis of frontotemporal skin and/or the ipsilateral scalp with subsequent alopecia.

Methods

Five recent clinical cases with necrosis of frontotemporal skin and/or the ipsilateral scalp with subsequent alopecia after HA filler injection into the temple were analyzed retrospectively. The patients underwent HAase injection via superficial temporal artery combined with adjunctive treatments, and the clinical progress was observed.

Results

Significant improvement was observed in terms of necrosis of frontotemporal skin and the ipsilateral scalp after treatment, and the patients were relieved of their clinical symptoms. Alopecia occurred approximately 1 to 2 weeks after HA filler injection, and the well-defined alopecia areas were formed 15 to 20 days after HAase injection. Patients were followed for 3 to 6 months. During follow-up, the skin lesions of all patients were restored to near normal appearance. Hair regrowth was observed 2 to 3 months after HAase treatment, and hair density nearly reached the normal level 3 to 4 months later.

Conclusions

Percutaneous superficial temporal arterial HAase injection is an effective treatment option for HA filler–induced necrosis of frontotemporal skin and/or the ipsilateral scalp with subsequent alopecia.

Level of Evidence: 4
Oral Presentation No. 10 Pharmacological therapy in patients with myocardial infarction with nonobstructive coronary arteries (MINOCA): long-term prognosis
Authors: Lopes Vanessa , Moreira Nádia , Fernandes Rafaela , Cunha Gil , Costa Gonçalo , Monteiro Eric , Fernandes Diogo , Guimarães Joana , Milner James , Marinho Vera , Monteiro Sílvia , Monteiro Pedro , Gonçalves Francisco , Gonçalves Lino
Published: October 2022

Background

The optimal management of myocardial infarction with nonobstructive coronary arteries (MINOCA) is still uncertain. This study sought to determine the association between pharmacological therapies after hospital discharge and the long-term prognosis of MINOCA patients.

Material and methods

We analyzed patients consecutively admitted to the coronary care unit with myocardial infarction (MI). Multivariate analysis was performed to determine which drugs were implicated in the prognosis of MINOCA patients. The primary endpoint was all-cause mortality at 5 years.

Results and conclusions

From a total of 3721 MI patients, MINOCA was identified in 11.6% (n = 430), of whom 56 (13.0%) experienced the primary endpoint. Median age was 66 years (IQR 19), and 51.6% (n = 222) of patients were male.

At discharge, 81.2% of MINOCA patients were prescribed aspirin, 87.4% a statin, 78.6% beta-blockers, and 66.7% angiotensin-converting enzyme inhibitors (ACEI). MINOCA patients were less likely to be prescribed these medications compared to patients with obstructive coronary artery disease (all P < 0.001). 1.4% (n = 6) of MINOCA patients died in the hospital, and the 5-year mortality rate was 13.0% (n = 56). In multivariate Cox regression, treatment with ACEI at discharge was found to be independently associated with a 5-year mortality benefit (HR = 0.29, 95% CI 0.12–0.67, adjusted P = 0.004) in MINOCA patients.

In conclusion, compared with patients with obstructive CAD, patients with MINOCA are less likely to be treated with secondary prevention drugs and are at lower risk of all-cause mortality during long-term follow-up. Treatment with ACEI seems to provide an additional mortality benefit in MINOCA patients.
Oral Presentation No. 48 Sex-based differences in patients with peripheral arterial disease admitted for acute coronary syndrome - Insights from a multicentre national registry
Authors: Cabral Margarida , Gonçalves Carolina , Fernandes Sara , Carvalho Mariana , Ruivo Catarina , Pernencar Sidarth , Loureiro Maria Fátima , Morais João
Published: October 2022

Atherosclerosis represents a systemic disease that can involve multiple vascular beds, including coronary artery disease and peripheral artery disease (PAD). Acute coronary syndrome (ACS) with concomitant PAD represents a high-risk subgroup that deserves special attention. In particular, sex-based differences in PAD treatment and outcomes have been discussed.

This study aimed to clarify the main differences in clinical outcomes between women and men with PAD admitted for ACS. The authors performed a retrospective analysis of adult patients with PAD, included in the Portuguese Registry on Acute Coronary Syndromes (ProACS) between October 2010 and July 2022. A P-value < 0.05 is statistically significant.

Of the total of 32 251 hospitalized patients admitted for ACS, 1588 (4.9%) had known PAD, of which 320 were women and 1268 men. Table 1 shows the most important baseline characteristics and differences between groups. After propensity score matching, with 640 patients, female gender appeared to be an independent factor for acute heart failure (OR 0.68, 95% CI [0.48, 0.96], P-value = 0.03) and in-hospital mortality (OR 0.36, 95% CI [0.17, 0.73], P-value < 0.01). However, there are no differences between sex for 1-year mortality (P-value = 0.70).

In conclusion, in this group of patients, PAD is less prevalent among women, and probably underdiagnosed. In addition, there is a significant difference in medication with fewer women taking acetylsalicylic acid, probably undertreated. Finally, women have more in-hospital complications, including mortality. Hence, additional efforts are needed in order to better understand sex-based differences in PAD and increase awareness of this condition in women.
Oral Presentation No. 006 Postoperative Myocardial Injury due to Platelet Reactivity in Patients undergoing Vascular Surgery
Authors: Zheng K L
Published: October 2022

Background

Postoperative myocardial injury (PMI) after major vascular surgery, detected by elevated cardiac troponin (cTn), has been associated with morbidity and mortality. It is unclear whether the pathophysiology of PMI is determined by increased platelet activity.

Objective

To examine the relationship between platelet activation (P-selectin expression) and PMI(cTn release as continuum) in patients undergoing elective open abdominal aortic surgery in the early post-operative period.

Methods

This prospective, single-centre, observational, cohort study included 33 patients undergoing elective open abdominal aortic surgery between March 2018 and April 2021. Patients were routinely treated with aspirin. Unstimulated platelet activation was measured by platelet bound P-selectin expression (range 0–100%). Explorative coagulation measurements were: stimulated platelet aggregation measured with the VerifyNow® assay (aspirin cartridge), with the Multiplate® analyzer (ASPI, ADP and TRAP) and stimulated coagulation status evaluated by the TEG® Haemostasis Analyzer System (global haemostasis cartridge). The primary outcome was cTn release assessed by the fifth generation high-sensitive cTn assay. Multivariable generalized linear mixed models were used to evaluate the association between platelet function and cTn concentrations over time.

Results

Ten patients (29.4%) developed PMI. Increased P-selectin expression directly after surgery was associated with the cTn concentrations over 48 h (β = 1.39(1.1–1.75), P = 0.0064). No association was found between P-selectin measured later (at 24 h or 48 h) after surgery and cTn concentrations. Furthermore, there was no association between the explorative coagulation parameters and cTn release.

Conclusion

Increased P-selectin expression measured directly after surgery is associated with elevated cTn concentrations in the early postoperative period in patients undergoing elective open abdominal aortic surgery.
Poster No. 009 In-hospital bleeding in acute coronary syndrome: new antithrombotics, old problems
Authors: Lopes Vanessa , Moreira Nádia , Fernandes Rafaela , Cunha Gil , Sousa José Pedro , Lopes João , Milner James , Marinho Vera , Monteiro Sílvia , Monteiro Pedro , Gonçalves Francisco , Gonçalves Lino
Published: October 2022

Background

Progress in decreasing ischemic complications in acute coronary syndrome (ACS) has come at the expense of increased risk of bleeding. This study sought to determine the incidence, predictors, and prognosis of in-hospital bleeding (IHB) in ACS patients.

Material and methods

We retrospectively analyzed patients consecutively admitted to the coronary care unit (CCU) with ACS. Patients who suffered clinically significant IHB were compared to the remaining ACS patients. The primary endpoint was all-cause in-hospital death.

Results and conclusions

From a total of 1032 ACS patients, clinically significant IHB was identified in 5.6% (n = 58) of patients, of whom 13 patients presented serious bleeding. Patients with IHB were older (P = 0.003), more often female (P = 0.012), were more likely to have prior heart failure (P = 0.007) and chronic kidney disease (P = 0.001). At admission, they presented more often with Killip-Kimball class > I (P = 0.001), lower hemoglobin (P = 0.013), lower eGFR (P = 0.005), and a higher CRUSADE score (P < 0.001). In multivariate logistic regression, female sex (OR = 2.26, 1.17–4–38, P = 0.023), acute kidney injury (OR = 2.23, 1.12–4.45, P = 0.028), and non-radial access in coronary angiography (OR = 2.04, 1.08–3.87, P = 0.028), were identified as independent predictors of IHB.

The primary endpoint occurred in 5.8% of ACS patients. Patients who suffered IHB were at higher risk of death during hospitalization (OR = 2.39, 95% CI 1.03–5.51, P = 0.042), but not during the 2-year follow-up (P = 0.429).

In conclusion, IHB is not an uncommon complication in ACS patients and is associated with an increased risk of in-hospital mortality.
Poster No. 043 A Case of Post Thrombotic Syndrome and AV Fistula arising from Recurrent DVT Secondary to May – Thurner Syndrome (MTS) in an Elderly Woman
Authors: Lim Angeline U Y , de Jesus Marilou , Posas Fabio Enrique , Martinez Marvin
Published: October 2022

May-Thurner Syndrome (MTS) remains to be an overlooked condition wherein the right common iliac artery compresses the left common iliac vein. Rarely reported, MTS has other different variants with the iliac vein being compressed by an ipsilateral artery. Iliofemoral DVT poses a significant impact because of venous claudication and DVT recurrence. MTS usually occurs in women, ages 20–40 y/o, and is thus rarely included in differential diagnosis of DVT in elderly patients presenting with persistent unilateral leg swelling. Treatment of DVT alone with anticoagulation is insufficient to address thrombotic MTS. Failure to address the mechanical compression leads to poor quality of life due to high predisposition to recurrent DVT, and at times to other complications such as post-thrombotic syndrome and formation of AV fistulas.

We present a case of an 89 year old woman, hypertensive, non-smoker, no history of cancer, presenting with progressive left lower extremity swelling with erythema, violaceous discoloration, varicosities, telangiectatic skin lesions, hyperpigmentation and calf tenderness. Ultrasound revealed DVT at common iliac vein extending to the popliteal veins. CT studies showed a left common iliac artery compressing the left common iliac vein with early enhancement of the common femoral vein, indicating presence of fistula. Peripheral angiography and venography findings were consistent with CT scan findings, with incidental findings of multiple small AV fistulas.

Anti-coagulation was given and IVC filter was inserted. An attempt to do catheter-directed thrombolysis was unsuccessful. Subsequently, she underwent Palma's surgery which provided significant improvement and was sent home ambulatory.
Poster No. 047 A comparative study of high-intensity statin therapy in post-acute coronary syndrome patients undergoing a cardiac rehabilitation program
Authors: Cabral Margarida , Carvalho Mariana , Santos Rita , Ferreira José Bernardo , Ruivo Catarina , Januário Filipa , Antunes Alexandre , Morais João
Published: October 2022

Aggressive lipid lowering has been shown to be a crucial part of secondary prevention after acute coronary syndrome (ACS). The selection of the best lipid-lowering agents is controversial, with some trials showing rosuvastatin as more efficacious in improving lipid profile compared to atorvastatin, others showing no difference. Another concern is the impact of statin therapy on the reduction of muscle oxidative capacity, and, consequently, on functional capacity.

This study aimed to analyse the differences in lipid profile and physical capacity in post-ACS patients undergoing a cardiac rehabilitation program (CPR), medicated with rosuvastatin versus atorvastatin.

A retrospective analysis of patients in phase 2 of CRP between 2017 and 2020 was performed. Two groups were created: group 1 for patients under atorvastatin 40 mg and group 2 under rosuvastatin 20 mg. Variables were analysed at the beginning and the end of phase 2, 12 weeks later. A P-value < 0.05 is statistically significant.

A total of 98 patients completed phase 2 of CRP, of which 14 are part of group 1, 67 of group 2, and 17 users of other lipid-lowering drugs. Table 1 shows the main characteristics. Univariate (table 2) and multivariate analyses show no differences regarding lipid profile or functional activity between groups.

In conclusion, in this group of patients, high-intensity rosuvastatin and atorvastatin in secondary prevention post-ACS had a comparable impact on lipidic profile, without a significant difference in functional activity, independently of age, sex or comorbidities. Larger randomized prospective trials, including phase 3 of CRP, are needed to confirm these results.
Poster No. 050 Klotho protein supports mechanical function and prevents MMP-mediated injury of heart during ischemia/reperfusion
Authors: Olejnik Agnieszka , Krzywonos-Zawadzka Anna , Banaszkiewicz Marta , Bil-Lula Iwona
Published: October 2022

Background

The injury of the myocardium during ischemia/reperfusion (IRI) involves metabolic, morphological, and contractile disorders. Klotho is a membrane or soluble anti-aging protein. Recent studies have proven the correlation between Klotho deficiency and the occurrence and development of cardiovascular diseases. The study aimed to evaluate the effect of Klotho protein on hearts subjected to IRI.

Material and methods

Isolated Wistar rat hearts perfused with the Langendorff method were subjected to ischemia, followed by reperfusion, in the presence or absence of Klotho protein. Hemodynamic parameters and the levels of nuclear factor kappa-light-chain-enhancer of activated B cells (NF-Κb), nitrate/nitrite, inducible nitric oxide synthase (iNOS), asymmetric dimethylarginine (ADMA), matrix metalloproteinase 2 (MMP-2), MMP-9 and tissue inhibitor of MMP type 4 (TIMP-4) were evaluated.

Results

Infusion supply of Klotho during IRI resulted in the recovery of contractile function (P = 0.031) and heart rate (P = 0.02). IRI activated MMP-2 (P = 0.042) and MMP-9 (P = 0.041) in hearts, as compared to aerobic control. Klotho contributed to increase in iNOS level (P = 0.02), and decreased levels of NF-Κb (P = 0.006), ADMA (P = 0.007), nitrate/nitrite (P = 0.022), MMP-2 (P = 0.024) and MMP-9 (P < 0.001), as compared to IRI group.

Conclusions

Klotho protein preserved heart mechanical function and reduced the level of proteolytic enzymes in the heart. Thus, Klotho can be recognized as a novel cardiopreventive/cardioprotective agent in ischemic damage.

This work was supported by the National Science Centre, Poland [grant number 2019/33/N/NZ3/01649].