bluuebunny/crossref_metadata_2025 huggingface dataset:
Legitimising Martial Law: Framing The 1974 Battle of Jolo (Sulu, Philippines) in the Bulletin Today Newspaper
Authors:   Division of Social Sciences, College of Arts and Sciences, University of the Philippines Visayas, Miagao, Iloilo, 5023 Philippines, Salomon Elgin Glenn R.
Published: August 2023

After President Ferdinand Marcos declared martial law on 21 September 1972, the Moro National Liberation Front (MNLF), a Muslim secessionist rebel group based in the Mindanao and Sulu archipelago waged war against the Manila-based government leading to armed clashes with the Armed Forces of the Philippines (AFP). One of their most violent battles happened on 7 February 1974, after rebels invaded the town of Jolo, the provincial capital of Sulu in the southern Philippines. With the help of state-controlled media like Bulletin Today, this battle became an avenue for the Marcos dictatorship to legitimise its authoritarian rule. Analysing frames of the Bulletin Today newspaper on the 1974 Battle of Jolo, this study argues that in an authoritarian regime where the government controlled the flow of information, media framing played a crucial role in suppressing the rebellion which aimed to generate support from the public. Through a close reading of Bulletin Today newspaper issues from February to April 1974, this study unpacks how the Marcos-controlled media filtered, fabricated, and censored news and editorial articles to frame the 1974 Battle of Jolo to strengthen the dictator Marcos’ authoritarian legitimacy and image-making project. This study suggests that the Marcos government discredited the MNLF by labelling them as Maoist Muslims. Attaching such connotations to the secessionist group, the regime framed the group as bearers of harmful behaviour and a threat to the goals and values that Filipino society upholds. The Bulletin Today also underlined the competence of the Philippine military and the constabulary in dealing with the crisis. However, the regime also censored pertinent information about the battle, including their role in the bombing and burning of Jolo.
Prosiding SERENADE #2 : Lokal itu Keren, Lokal itu Masa Kini
Authors: SERENADE 2023
Published: August 2023

FULL PROSIDING SERENADE 2023 
https://tinyurl.com/Prosiding-SERENADE-2023
CONCEPT OF NATUROPATHYDIET AND FASTING THERAPY IN LIFE STYLE INDUCED DISEASES: A REVIEW ARTICLE
Authors:   Assistant Professor Department of Nutrition and Dietetics, Yenepoya Naturopathy and Yogic Sciences College and Hospital, Deralakatte, Karnataka., D. Souza H. Sunitha
Published: August 2023

Diet is a fundamental component of naturopathy system of medicine. It is regarded as medicine, apparent, different and significant in naturopathy. Fresh seasonal and local fruits, vegetables, green leafy vegetables and sprouts are excellent form of natural foods. Being alkaline in nature, purifies the body, and improves the health and immunity.Fasting is first choice of treatment in this system and can be defined as total rest physical, physiological, sensory and mental rest, which includes voluntary total abstinence from intake of any kind of food, solid or liquid that demands digestion, except water, for a definite purpose and period of time.Fasting and naturopathy diet are vital treatments in life style induced diseases which occur due to the unhealthy behaviours, other factors like persons habits, behaviours and practices.Naturopathy diet â€“a holistic diet, enhances healing capacity and acts as a natural healing method for various lifestyle diseases and fasting stimulates the vital protective mechanisms which helps in the prevention and management of diseases and encourages a healthier life.
CORRELATION BETWEEN EXAMS AND MIGRAINE AMONG MEDICAL STUDENTS IN MADINAH, SAUDI ARABIA
Authors:   College of Medicine, Al-Rayan Colleges, Madinah, Saudi Arabia., Suleiman Osman , H Aljohani Asayil ,   College of Medicine, Al-Rayan Colleges, Madinah, Saudi Arabia., A Aljohani Shahad ,   College of Medicine, Al-Rayan Colleges, Madinah, Saudi Arabia., N. Almghsal Hamidah ,   College of Medicine, Al-Rayan Colleges, Madinah, Saudi Arabia., H. Alhelali Majidah ,   College of Medicine, Al-Rayan Colleges, Madinah, Saudi Arabia.
Published: August 2023

Background: The migraine headache is a common and potentially debilitating disorder often treated by family physicians the students lately is suffering inexam time with migraine headache. Objective:To determine migraine prevalence, prediction, triggers and effects during examinations among medical students in Al Rayan college, Madinah,Saudi Arabia, 2022-2023. Methods: A cross-sectional study well be used. The date collection method is done by sending an online questionnaire to students in Al Madinah Will be validated. The simple size was 343 students in Al - Rayan College, Madinah, Saudi Arabia 2022-2023. Data will be analysed by Microsoft Excel and SPSS. Results: Our study included 345 medical students, whose study years ranged from the fifth year, the sixth year, and the internship year, the prevalence of migraine was (28.7%). More than half of the participants were females, 212 (61.2%), and 134 (38.8%) % were male. In bi variate analysis, migraine was associated with gender (female), family history, and chronic diseases, namely irritable bowel syndrome (IBS), asthma and hypertension. The most frequently reported triggers of migraine were sleep disturbance (76.8%) and stress (61.2%). Photophobia and difficulty in concentration were the commonest associated symptoms. Conclusion:Participants in the current study showed a relatively high prevalence of headaches and migraines. Female gender in the sixth academic year and irritable bowel syndrome enrolment were predictors of migraine. Stress and sleep disturbances are the most common triggers.
A CASE STUDY OF AYURVEDIC MANAGEMENT OF VATA-KAPHAJA PRATISHYAYA W.S.R. CHRONIC SIMPLE RHINITIS
Authors:   Professor, Shalakya Tantra, Ashwin Rural Ayurved College, Sangamner, Ahmednagar., Chetan Paner Paras
Published: August 2023

Chronic simple rhinitis may be correlated with Vata-KaphajaPratishyaya. remedy of Pratishyaya is both Shodhana or Shamana, in line with Bala and Dosha of the patient. In Pratishyaya preference of Shodhana remedy may be Nasya, Vamana, Niruhabasti, which allows to remove the vitiated Dosha from Shira (Head), Aamashaya with Pakvashaya and breakdown the Samprapti of Pratishyaya. Pachana medicine is previous required for proper Shodhana and Rasayana medicinal drug provide best end result after Shodhana. In this example of Pratishyaya the road of treatment is Pachana, Nasya, Niruhabasti, Vamana and Vardhman PippaliRasayana, patient get commenced remedy from first day of remedy and whole alleviation after Vamana and also now not get the recurrence after of completion of Vardhman PippaliRasayana. Materials and Methods: The subject who approached Shalakya Tantra OPD of Shalakya Tantra, Ashwin Rural Ayurved College, Sangamner, Ahmednagar with symptoms of Migraine since3 months was systemically reviewed and Nasya line of treatment is adopted. Results: The subject showed marked improvement as depicted in the scoring scale before and after treatment. Discussion: By adopting the holistic approach with both internal and external treatment modalities an attempt is made to bring about satisfactory results.
IMPLEMENTATION OF SUPERVISION PRINCIPLES BY THE REGIONAL SUPERVISORY COUNCIL IN THE EXAMINATION PROCESS OF NOTARIES WHO ARE ALLEGEDLY VIOLATING THE CODE OF ETHICS (COURT DECISION STUDY NUMBER 235/G/2019/PTUN.KT)
Authors:   Master Student,FacultyofLaw,JenderalSoedirmanUniversity,Indonesia., Pandu Jagendra Opras , Wasi Bintoro Rahadi ,   Senior Lecturer,FacultyofLaw, JenderalSoedirmanUniversity, Indonesia., Sudrajat Tedi ,   Senior Lecturer,FacultyofLaw,JenderalSoedirmanUniversity,Indonesia.
Published: August 2023

The application of the principle of supervision by the Notary Supervisory Board must be oriented towards the truth according to the laws and regulations. Thus, the Notary who is suspected of violating the code of ethics in the examination is based on the Regulation of the Minister of Law and Human Rights No. 15 of 2020 concerning the procedures for the examination by the Notary Supervisory Board of the Notary. Legal remedies that can be taken by a notary who is subject to sanctions by the Notary Supervisory Council is to appeal a letter of objection by Article 28 paragraph 1 of the Regulation of the Minister of Law and Human Rights number 15 of 2020 concerning Procedures for Examination of the Supervisory Board of Notaries, but in practice, there are problems regarding the implementation examination of a notary suspected of violating the code of ethics, occurred in the case of the decision of the Jakarta State Administrative Court Decision Number 235/G/2019/PTUN.KT.
IDENTIFICATION OF BENZOIC ACID BY GC AND MASS SPECTROMETRY
Authors:   Sri Satya Sai University of Technology and Medical Sciences, Sehore., a Kalpana , Sharma Pushpendra ,   Sri Satya Sai University of Technology and Medical Sciences, Sehore., Jain Neelu ,   Sri Satya Sai University of Technology and Medical Sciences, Sehore.
Published: August 2023

Benzoic acid is an aromatic carboxylic acid naturally present in plant and animal tissues which can also be produced by microorganisms. Benzoic acid and a wide range of derivatives and related benzenoid compounds, such as salts, alkyl esters, parabens, benzyl alcohol, benzaldehyde and benzoyl peroxide, are commonly used as antibacterial and antifungal preservatives and as flavouring agents in food, cosmetic, hygiene, and pharmaceutical products. Benzoic acid (BA) is a commonly used antimicrobial preservative in food and beverages, especially in carbonated beverages, as it presents in its strongest antibacterial activity at pH 2.5â€“4.0. BA has inhibitory effects on the proliferation of bacteria and yeasts, a major cause of food spoilage. Although the addition of BA can extend the shelf life of drinks and prevent nutritional losses.Excessive intake of BA may cause diarrhea, abdominal pain, and other symptoms and even interfere with the intermediate metabolic processes of the body.
LEGAL REFLECTION ON SPURRING WILDLIFE INVESTMENTS WHILST EMBRACING WILD ANIMALS CONSERVATION IN TANZANIA
Authors: Bonephace Mectrida
Published: August 2023

Tanzania is diversifying wildlife investments. The Special Wildlife Investment Concession Area, (the SWICA) is set aside. The regulations to achieve the purpose are in place.The regulations enlighten on the procedures of carrying out investments within the SWICA. This paper reviewson this new investment schemewhether itwill spare the ecosystem, specifically, the safety and survival of wild animals.The invited investments activities connote disturbance on the lives of wild animals. This paper observes that, the cumulative promulgation of the regulations threatens the life of wild animals. The apprehension of ecosystem disturbances in the SWICA is too wide to connote probable security on the lives of wild animals. Moreover, the avenues for some actors to excises their wisdom, aside of the regulations may invite unnecessary difficulties between the investors and the authority. Lastly, wild animals are likely to suffer a significant prejudice if investments in the SWICAs get through.
Revistas académicas y responsabilidad
Authors: Castrillón Castrillón Andrés Alfredo
Published: August 2023

Los artículos que conforman este nuevo número exponen temáticas relevantes y de interés para las ciencias sociales, a nivel local y regional, que tienen como objetivo el estudio de situaciones que impactan las sociedades en la actualidad. El título de la presentación es una tímida alusión a la editorial del profesor Oscar Licandro, quien reflexiona acerca de los bienes comunes y la responsabilidad social de las revistas académicas, una parte de esta labor recae sobre las editoriales y las universidades. El profesor considera que el término bienes comunes se puede extender hasta el conocimiento y su divulgación producido en las universidades que se ve cooptado por agencias externas a las mismas universidades y que ante todo se lucran e imponen estándares desiguales a nivel global, en el que la región latinoamericana se ve claramente afectada. Invitamos a leer la editorial y a establecer diálogo con el autor y los investigadores.
El conocimiento producido por las universidades: un bien común que requiere la responsabilidad social de las revistas académicas latinoamericanas
Authors: Licandro Goldaracena Oscar Daniel
Published: August 2023

El término “bienes comunes” (common goods) fue acuñado para referirse a los recursos naturales cuyo uso abusivo y/o descontrolado está causando males a la humanidad: el aire, el agua de los ríos, los bosques, la capa de ozono, etc. Posteriormente, emergieron opiniones que proponen que algunos servicios sociales (la educación, la atención de salud, etc.) y las creaciones colectivas de la humanidad (el arte, el conocimiento científico, etc.) también lo son. Los bienes comunes son “recursos, que más allá de la propiedad o la pertenencia, asumen, por su propia vocación natural y económica, funciones de interés social” (Subirats Humet, 2011, p. 196). Estos bienes se diferencian de los demás tipos de bienes (privados y públicos) porque todas las personas tienen el derecho de acceder a ellos por el solo hecho de ser miembros de la sociedad. Por lo tanto, los académicos y las revistas académicas deberían gestionar el conocimiento producido en las universidades como un bien común, lo cual implica la responsabilidad social de asegurar su calidad, su pertinencia social y su difusión sin restricciones.
Experimental analysis on the structural seismic behavior of steel frame-precast steel reinforced concrete (SRC) infill wall with lateral force resisting
Authors: Wang Xiaohui , Zhang Hui , Hu Xiaolong
Published: August 2023

The structural seismic performance of steel frame-precast steel reinforced concrete (SRC) infill wall with lateral force resisting is analyzed, and the structural strength of steel frame-precast SRC infill wall with lateral force resisting is improved. The structural seismic performance optimization model of SRC lateral force resisting wall based on buckling restrained brace is proposed. Through the finite element simulation software, the seismic performance and response results of ordinary steel frames, buckling restrained braced steel frames and a relatively new type of sacrificial-energy dissipation braced steel frames under earthquake are compared and analyzed to demonstrate the applicability and performance advantages of sacrificial-energy dissipation braced steel frames in the steel frame braced structure system. Under the action of horizontal earthquake, the supporting members experience reciprocating axial tension and compression cycles, which dissipate a large amount of seismic energy input into the structure. Therefore, the buckling restraint support method can be used in the structure to improve the support strength. Under horizontal reciprocating load action of earthquake, the ability to consume seismic energy through self-hysteresis of the brace is poor. Experimental research shows that, the unbalanced force formed in the beam of the frame beam under seismic action will form a plastic hinge at the beam end at both ends of the frame beam. Especially when the brace is buckling unstable and the stiffness of the frame beam is small, the plastic hinge effect at the beam end is significant. This phenomenon may cause damage to the frame beam or even local floor subsidence. The buckling restraint support has a full hysteresis area under axial tension and compression, and its mechanical performance is excellent. It is obviously superior to ordinary steel bracing in energy dissipation capacity and seismic performance. It can accurately predict the bearing capacity of reinforced concrete under strong earthquake, and the energy dissipation distribution is more in line with the requirements of “energy seismic design method”.
Evaluation of the flow state and static performance of smooth annular liquid seals
Authors: Yang Zhongjie , Feng Jin , Wan Jingyu , Yu Xiaobin , He Zhangjin , Zhang Wanfu
Published: August 2023

The static fluid-induced force and stiffness coefficient of the smooth annular seal directly affect the rotor system stability. In this paper, a computational ﬂuid dynamics method is applied to investigate the ﬂow characteristics of a smooth annular seal for various eccentricities, discharge/supply pressures and rotational speeds under different flow conditions (laminar, transition, and turbulent flow). The influence factors and formation mechanism of the static instability in the smooth annular liquid seal are analyzed. Results show that laminar flow dominates the flow state at a rotational speed of ω= 2000 rpm. As the rotational speeds increase, the transition flow (2000-7000 rpm) gradually transits to the turbulent regime (ω> 7000 rpm). The direct static stiffness decreases first and then increases from laminar to transition flow state, and the viscosity effect is the dominant factor. For transition and turbulent flow with high eccentricities (ε= 80 %), the dominant viscous effect and inertial effect lead to the negative radial force and negative direct static stiffness coefficients. The smooth annular liquid seal shows best performance in the laminar flow and worst performance in the turbulent flow.
Determining tunnel stability across fault zones under seismic loading based on load/unload response ratio theory
Authors: Hui Qiang , Gao Feng , Tan Xukai , You Dongmei
Published: August 2023

Geological faults impair tunnel stability during earthquakes. This study establishes a tunnel dynamic stability evaluation index based on load/unload response ratio (LURR) theory. It considers a seismic wave as a load/unload parameter and tunnel structure strain response as a response parameter. The rationale behind this evaluation index and the factors affecting tunnel stability across fault zones under seismic conditions are investigated. Compared to the traditional dynamic instability criterion, the LURR accurately measures the degree of structural deviation from the steady state and better determines the potential destabilization region of the structure. As the peak value of the input seismic wave increases, the LURRs of the more unstable parts increase, while the LURRs of the stable parts remain unchanged. According to LURR theory, the size of the range affected by the fault on the tunnel during an earthquake depends mainly on inherent fault properties (i.e., the dip angle, strike, and thickness), independent of the earthquake intensity. Because the LURR can theoretically be infinite, its dynamic instability threshold cannot be determined accurately.
‘WaSH Futurism’: exploring post-SDG6 targets using the Nominal Group Technique for more equitable global agenda setting
Authors: Hales Georgia , Hasan Bushra S. F. , Balongo Oscar , Meshvania Jay , Sanchez-Martinez Reychel , Shachinda Charles , Hutchings Paul , Bartram James
Published: August 2023

Sustainable Development Goal 6 (SDG6) is grounded in human rights and derives from international policies refined over decades. We argue that much of this agenda setting and monitoring reflects or gives way to neo-colonialism and neo-liberalism. We implement an online version of the Nominal Group Technique to explore its efficacy for more equitable global agenda setting. We apply the technique to a group of 19 graduate WaSH students – from diverse professional backgrounds and originating from and having worked in all global regions – to gain their insights on future WaSH issues to be included in global targets. This was preceded by preparatory exercises on WaSH progress and influential contextual factors. We thus demonstrate a novel and systematic application of the NGT and discuss its potential to be used in challenging neo-colonial and neo-liberal agenda setting. The results also provide an early assessment of future priorities that could inform post-SDG target setting including: inclusivity among populations and settings, hygiene, menstrual health, sustainability, circular economy, climate resilience, preventing infectious disease transmission, and universal ‘safely managed services’. These are compared with themes highlighted in Joint Monitoring Programme reports, SDG6 indicators and General Comment 15: The Human Right to Water.
The Treatment of a New Entity in Advanced Non-small Cell Lung
Cancer: MET Exon 14 Skipping Mutation
Authors: Rocco Danilo , Gravara Luigi Della , Palazzolo Giovanni , Gridelli Cesare
Published: August 2023

Background:

MET (MET Proto-Oncogene, Receptor Tyrosine Kinase) exon
14 skipping mutation represents one of the most common MET alterations, accounting
for approximately 1-3% of all mutations in advanced lung adenocarcinomas. While until
2020 no specific treatment was available for this subset of patients, as of today, three
MET Tyrosine Kinase Inhibitors (TKIs) are currently approved in this setting, namely
capmatinib, tepotinib and savolitinib.

Objective:

This article aims to provide an extensive overview of the current therapeutic
standard of care for exon 14 skipped advanced Non-small Cell Lung Cancer (NSCLC) patients,
alongside with mentions of the main future challenges and opportunities.

Conclusion:

FDA-approved MET-TKIs currently represent the best option for treating
exon 14 skipped advanced NSCLC patients, thanks to their excellent efficacy profile,
alongside their manageable safety and tolerability. However, we currently lack specific
agents to treat patients progressing on capmatinib or tepotinib, due to a limited understanding
of the mechanisms underlying both on- and off-target resistance. In this respect,
on-target mutations presently constitute the most explored ones from a mechanistic point
of view, and type II MET-TKIs are currently under investigation as the most promising
agents capable of overcoming the acquired resistance.
Current State of Lipid Nanoparticles (SLN and NLC) for Skin Applications
Authors: Eroğlu Cemre , Sinani Genada , Ulker Zeynep
Published: August 2023

The increasing knowledge on skin physiology, formulation science and nanotechnology has led to
continuous improvements in cosmetics, and introduction of dermocosmetics has been increasing particularly
for the management of skin disorders such as acne, eczema, psoriasis, etc. Nowadays, research has been focused
on the development of products which can efficiently administer active compounds to the target skin layers
while minimizing side effects. The use of multifunctional lipid nanoparticles for cosmetic and dermocosmetic
purposes is promising not only because biocompatible ingredients are used in their composition, but also because
of their ability to show enhanced skin penetration. Although the introduction of liposomes has been a hallmark
of lipid nanoparticles, development of novel systems capable of encapsulating active compounds with tunable
release profiles, that show good stability, are easy to manufacture and handle remains a necessity. Solid
lipid nanoparticles (SLN) were introduced as alternative formulations for emulsions, liposomes and polymeric
nanoparticles, whereas nanostructured lipid carriers (NLC) were developed later as second-generation nanoparticles.
However, both SLN and NLC show many inherited advantageous properties to be used for dermal applications
including ability to provide occlusion and photoprotective effect and skin hydration, and various SLN
and NLC based products are already in the market. This review provides an overview on the current state-of-art
of SLN and NLC particularly for cosmetic and dermocosmetic purposes, discuss their formulation composition,
structures and preparation techniques. Their use for the topical delivery of active compounds in different skin disorders
is highlighted along with examples of commercialized products.
Delivery of Agarose-aided Sprays to the Posterior Nose for Mucosa
Immunization and Short-term Protection against Infectious Respiratory
Diseases
Authors: Seifelnasr Amr , Talaat Mohamed , Si Xiuhua April , Xi Jinxiang
Published: August 2023

Aim:

The study aimed to deliver sprays to the posterior nose for mucosa immunization
or short-term protection.

Background:

Respiratory infectious diseases often enter the human body through the nose. Sars-
Cov-2 virus preferentially binds to the ACE2-rich tissue cells in the Nasopharynx (NP). Delivering
medications to the nose, especially to the NP region, provides either a short-term protective/
therapeutic layer or long-term mucosa immunization. Hydrogel-aided medications can assist
film formation, prolong film life, and control drug release. However, conventional nasal sprays
have failed to dispense mediations to the posterior nose, with most sprays lost in the nasal valve
and front turbinate.

Objective:

The objective of the study was to develop a practical delivery system targeting the posterior
nose and quantify the dosimetry distribution of agarose-saline solutions in the nasal cavity.

Methods:

The solution viscosities with various hydrogel concentrations (0.1-1%) were measured
at different temperatures. Dripping tests on a vertical plate were conducted to understand the hydrogel
concentration effects on the liquid film stability and mobility. Transparent nasal airway
models were used to visualize the nasal spray deposition and liquid film translocation.

Result:

Spray dosimetry with different hydrogel concentrations and inhalation flow rates was
quantified on a total and regional basis. The solution viscosity increased with decreasing temperature,
particularly in the range of 60-40oC. The liquid viscosity, nasal spray atomization, and liquid
film mobility were highly sensitive to the hydrogel concentration. Liquid film translocations significantly
enhanced delivered doses to the caudal turbinate and nasopharynx when the sprays were
administered at 60oC under an inhalation flow rate of 11 L/min with hydrogel concentrations no
more than 0.5%. On the other hand, sprays with 1% hydrogel or administered at 40oC would significantly
compromise the delivered doses to the posterior nose.

Conclusion:

Delivering sufficient doses of hydrogel sprays to the posterior nose is feasible by
leveraging the post-administration liquid film translocation.
Aminoglycosides: Single- or Multiple-daily Dosing? An Updated Qualitative Systematic Review of Randomized Trials on Toxicity and Efficacy
Authors: Karimzadeh Iman , Abdollahpour-Alitappeh Meghdad , Ghaffari Shokouh , Mahi-Birjand Motahareh , Barkhordari Amin , Alemzadeh Effat
Published: August 2023

Introduction:

Aminoglycosides are among the first-choice antibiotics for
routine clinical use. However, dose-limiting factors such as ototoxicity and nephrotoxicity
are considered as serious complications of aminoglycosides.

Objective:

In this systematic review, the main goal was to investigate the efficacy and
incidence of nephrotoxicity and ototoxicity of once-daily dosing (ODD) and multiple daily
dosing (MDD) regimens of aminoglycosides through available randomized controlled
trials (RCTs).

Methods:

We performed a literature-based research in relevant databases, including
EMBASE, MEDLINE, and SCOPUS published between 1987 and 2023 using the
keywords “aminoglycosides”, “pharmacokinetics”, “ODD”, “MDD”, “once daily”, “multiple
daily”, “dosing regimen”, “nephrotoxicity”, “ototoxicity”, “efficacy”, “safety”, and “toxicity”.
As so told, the results of this article were limited to papers available in English. Our initial
search yielded 1124 results. After a review of the titles and abstracts of the articles, 803
articles were excluded from this study because they did not address the toxicity and
effectiveness of ODD versus MDD of aminoglycosides. A total number of 20 studies on
gentamicin, tobramycin, netilmicin, and amikacin met the inclusion criteria for the
efficacy of aminoglycosides and their role in ototoxicity and nephrotoxicity were included
in this review. Studies recruited different age classes, and the age of relevant cohorts
varied from only a few days to more than 70 years.

Results:

The most common clinical
condition in the included studies was cystic fibrosis.

Conclusion:

In most studies, there were no significant differences between the two
regimens regarding ototoxicity. In addition, the ODD regimens were safer than MDD
concerning nephrotoxicity.
Functional MRI Techniques Suggesting that the Stress System Interacts
with Three Large Scale Core Brain Networks to Help Coordinate the
Adaptive Response: A Systematic Review
Authors: Paltoglou George , Stefanaki Charikleia , Chrousos George P.
Published: August 2023

Objective:

Synthesis of functional MRI (fMRI) and functional connectivity (FC) analysis
data on human stress system (SS) function, as it relates to the dynamic function of the Salience (SN),
Default Mode (DMN) and Central Executive (CEN) networks.

Methods:

Systematic search of Medline, Scopus, Clinical Trials.gov, and Google Scholar databases of
studies published prior to September 2022 resulted in 28 full-text articles included for qualitative synthesis.

Results:

Acute stress changes the states of intra-/inter- neural network FCs and activities from those of
resting, low arousal state in the SN, DMN and CEN, during which intra- and inter-network FCs and
activities of all three networks are low. SS activation is positively linked to the activity of the SN and
negatively to that of the DMN, while, in parallel, it is associated with an initial decrease and a subsequent
increase of the intra- network FC and activity of the CEN. The FC between the DMN and the
CEN increases, while those between the SN and the CEN decrease, allowing time for frontal lobe
strategy input and “proper” CEN activity and task decision. SN activation is linked to sensory hypersensitivity,
“impaired” memory, and a switch from serial to parallel processing, while trait mindfulness
is associated with FC changes promoting CEN activity and producing a “task-ready state”.

Conclusion:

SS activation is tightly connected to that of the SN, with stress hormones likely potentiating
the intra-network FC of the latter, attenuating that of the DMN, and causing a biphasic suppression-
to-activation response of the CEN, all adaptive changes favoring proper decisions and survival.
Peripheral Nervous System Pain Modulation
Authors: Karcz Marcin , Gharibo Christopher
Published: August 2023

The percutaneous technique of electrode insertion in the vicinity of the greater occipital
nerves to treat occipital neuralgia was first described in the 1990s by Weiner and Reed. This subsequently
stimulated awareness of peripheral nerve stimulation (PNS). The more recent advent emergence
of a minimally invasive percutaneous approach by way of using ultrasound has further increased
the interest in PNS as a viable alternative to more invasive techniques. PNS has become more popular
recently and is increasingly used to treat various pain conditions. Its foundation is fundamentally
based on the gate control theory, although the precise mechanism underlying its analgesic effect is still
indefinite. Studies have demonstrated the peripheral and central analgesic mechanisms of PNS by
modulating the inflammatory pathways, the autonomic nervous system, the endogenous pain inhibition
pathways, and the involvement of the cortical and subcortical areas. Peripheral nerve stimulation
exhibits its neuromodulatory effect both peripherally and centrally. Further understanding of the modulation
of PNS mechanisms can help guide stimulation approaches and parameters to optimize the use
of PNS. his chapter aims to review the background and mechanisms of PNS modulation. PNS is becoming
one of the most diverse therapies in neuromodulation due to rapid evolution and expansion. It
is an attractive option for clinicians due to the simplicity and versatility of procedures that can be
combined with other neuromodulation treatments or used alone. It has a distinct role in the modulation
of functional conditions.
Neurotensin and Neurotensin Receptors in Stress-related Disorders:
Pathophysiology & Novel Drug Targets
Authors: Kyriatzis Grigorios , Khrestchatisky Michel , Ferhat Lotfi , Chatzaki Ekaterini Alexiou
Published: August 2023

Neurotensin (NT) is a 13-amino acid neuropeptide widely distributed in the CNS that has
been involved in the pathophysiology of many neural and psychiatric disorders. There are three known
neurotensin receptors (NTSRs), which mediate multiple actions, and form the neurotensinergic system
in conjunction with NT. NTSR1 is the main mediator of NT, displaying effects in both the CNS and
the periphery, while NTSR2 is mainly expressed in the brain and NTSR3 has a broader expression pattern.
In this review, we bring together up-to-date studies showing an involvement of the neurotensinergic
system in different aspects of the stress response and the main stress-related disorders, such as
depression and anxiety, post-traumatic stress disorder (PTSD) and its associated symptoms, such as
fear memory and maternal separation, ethanol addiction, and substance abuse. Emphasis is put on
gene, mRNA, and protein alterations of NT and NTSRs, as well as behavioral and pharmacological
studies, leading to evidence-based suggestions on the implicated regulating mechanisms as well as
their therapeutic exploitation. Stress responses and anxiety involve mainly NTSR1, but also NTSR2
and NTSR3. NTSR1 and NTSR3 are primarily implicated in depression, while NTSR2 and secondarily
NTSR1 in PTSD. NTSR1 is interrelated with substance and drug abuse and NTSR2 with fear
memory, while all NTSRs seem to be implicated in ethanol consumption. Some of the actions of NT
and NTSRs in these pathological settings may be driven through interactions between NT and corticotrophin
releasing factor (CRF) in their regulatory contribution, as well as by NT’s pro-inflammatory
mediating actions.
α,α-Dibromoketones as Synthetic Equivalents of α-Bromoketones for the
Synthesis of Thiazolo[3,2-a]benzimidazoles
Authors: Kumar Ravi , Nair Reshmi R , Prakash Richa , Bae Taeho , Dohi Toshifumi , Prakash Om
Published: August 2023

Utilization of α,α-dihalocarbonyl compounds as synthetic equivalents to α-halocarbonyl
compounds has been explored in the synthesis of a wide range of highly useful heterocycles and α-
functionalized ketones. The continuously growing demand of α,α-dibromoketones, as highly reactive
and mild synthetic precursors/intermediates, to carry out selective organic transformations, prompted
us to investigate their potential application for the synthesis of thiazolo[3,2-a]benzimidazoles. In this
study, a remarkable application of α,α-dibromoacetophenones 5a-g in the development of a facile protocol
for the synthesis of thiazolo[3,2-a]benzimidazoles 4a-g by avoiding the use of lachrymatory α-
haloketones is described. Although the mechanism for the debromination from the intermediate compound
6 under these conditions is not confirmed, possible pathways have been suggested.
The Role of Gender in Turkish Women’s Pregnancy Experiences
Authors: Özer Betül Uzun , Topatan Serap
Published: August 2023

Background:

Apart from the biological changes women experience throughout pregnancy, their exposure to a gender discrimination stemming from cultural values adopted by the society in which they live can make it difficult for them to adapt to pregnancy and thus lead to negative pregnancy experiences.

Aim:

This research was conducted using a cross-sectional and relation-seeking approach to evaluate the effects of social gender inequality on pregnancy experiences.

Methods:

Data for this cross-sectional and relation-seeking study were gathered between 25 November 2019 and 25 January 2020 using face-to face interviews the researcher conducted with childbearing women who visited the outpatient clinic and non-stress test units of a hospital for the pregnancy follow-up.

Results::

When using the Pregnancy Experiences Scale to assess childbearing women, higher scores indicated more positive emotions than negative emotions. Independent variables that affect the scores on the Pregnancy Experiences Scale include a willingness to be pregnant, the baby's sex, the woman’s income status, gestational week and the Perception of Gender Scale (p< 0.005). A positive but weakly significant relationship was found among the total score on the Perception of Gender Scale, the total score on the Pregnancy Experiences Scale and the average scores of positive emotions intensity and frequency in all sub-dimensions (p< 0.005).

Conclusion:

Based on the data, we conclude that women’s pregnancy experiences are generally positive, and that social gender inequality is a significant determinant affecting pregnancy experiences.
A Comprehensive Review on Prospects of Polymeric Nanoparticles for
Treatment of Diabetes Mellitus: Receptors-Ligands, In vitro & In vivo
Studies
Authors: Jain Arinjay , Dawre Shilpa
Published: August 2023

As per International Diabetes Federation Report 2022, worldwide diabetes mellitus (DM)
caused 6.7M moralities and ~537M adults suffering from diabetes mellitus. It is a chronic condition due
to β-cell destruction or insulin resistance that leads to insulin deficiency. This review discusses Type-1
DM and Type-2 DM pathophysiology in detail, with challenges in management and treatment. The toxicity
issues of conventional drugs and insulin injections are complex to manage. Thus, there is a need
for technological intervention. In recent years, nanotechnology has found a fruitful advancement of
novel drug delivery systems that might potentially increase the efficacy of anti-diabetic drugs. Amongst
nano-formulations, polymeric nanoparticles have been studied to enhance the bioavailability and efficacy
of anti-diabetic drugs and insulin. In the present review, we summarized polymeric nanoparticles
with different polymers utilized to deliver anti-diabetic drugs with in vitro and in vivo studies. Furthermore,
this review also includes the role of receptors and ligands in diabetes mellitus and the utilization
of receptor-ligand interaction to develop targeted nanoparticles. Additionally, we discussed the utility of
nanoparticles for the delivery of phytoconstituents which aids in protecting the oxidative stress generated
during diabetes mellitus. Atlast, this article also comprises of numerous patents that have been filed
or granted for the delivery of antidiabetic and anticancer molecules for the treatment of diabetes mellitus
and pancreatic cancer.
Synthesis of New Zirconium (IV) Schiff-base Complexes: Spectral, Theoretical,
and Molecular Docking Studies
Authors: Dhingra Naveen , Khaturia S. , Solanki VS , Singh Har Lal
Published: August 2023

Background:

The development of the discipline of coordination chemistry owes a great deal to the use of Schiff-base metal chelates. Both Schiff base ligands and metal complexes are of interest due to their potential pharmacological effects. Schiff base derivatives have an extensive range of biological effects, including antitumor, antifungal, antibacterial, anticonvulsant, and antiviral properties.

Objective:

This study aimed to study the inorganic compound-based metallodrugs that have recently come into existence to provide an effective mechanism for medications that depend on the metal used and its characteristics. An effective platform for diverse pharmacological and therapeutic uses can be found in medicinal complex substances.

Methods:

The bi-molar reactions of zirconium tetrachloride with bidentate ligands were carried out in dry THF and were characterized by IR, UV-Visible, NMR and C, H, N, S analysis. The DFT method was used to investigate the molecular stability and bond strengths. Gaussian 09 and MolDock were used to optimise the geometry and to calculate the binding energy of all the complexes, respectively.

Results:

The analysis of the data revealed that the Schiff base, which has bivalent ligands (NS), was coordinated to zirconium via nitrogen and sulfur atoms. The optimum values for the structural parameters were calculated by density functional theory. Compound 5 showed the highest MolDock Score (-123.47 kcal/ mol) and H-bond interaction with active amino acids.

Conclusion:

The spectroscopic result indicates that the zirconium compounds were all non-electrolyte monomers with deformed octahedral structures. Compound 5 was shown to be the most active and effective of the bunch by both Gaussian software calculations and molecular docking study.
Herbal Remedies: An Emerging Alternative for the Treatment of Pandemic Diseases
Authors: Nistane Neha T. , Kale Mayur B. , Das Renuka J. , Umare Mohit D. , Umekar Milind J. , Hemke Atul T. , Gajbhiye Vishal R.
Published: August 2023

Pandemics are large-scale epidemics of infectious illness that may cause major economical,
cultural, and political upheaval while also increasing illness and mortality across a huge geographic
area. Evidence shows that pandemics have increased during the last century as a result of
increasing international travel and connectivity, industrialization, agricultural expansion, and higher
destruction of the natural environment. Over time, emerging pathogen strains cause pandemics
that raise suffering, death, and instability in countries. Flu, plague, cholera, HIV, and the current
COVID-19 pandemic caused by a novel coronavirus are just a few of the pathogen outbreaks. Unfortunately,
given the lack of information and instruments to tackle the problem, managing new and
developing infections is frequently challenging. Yet, the use of herbal remedies to treat new and
developing infectious illnesses has received much interest. Until the invention of antibiotics, herbal
plants, their preparations, and extracted phytoconstituents were reported to be efficient in reducing
infectious diseases. Plants contain numerous complex metabolites, such as amino acids, alkaloids,
tannins, flavonoids, terpenoids, and glycosides, that show different therapeutic activities. This review
provides vital and useful information regarding herbal drugs and their effectiveness against
various pathogens that cause major pandemics.
Filosofia del peggio
Authors: Grifoni Emanuele Bottazzi
Published: August 2023

This article considers Clement Rosset’s Logique du pire and Hans Jonas’ Das Prinzip Verantwortung from the point of view of the worst. These are diametrically opposed books in many ways. If for the former everything is chance (hazard) and no action is possible except that of exterminating laughter, for the latter action to avert catastrophe is a duty and it is mere gamble (azzardo) to add chance to chance in reckless actions. Both solutions are insufficient. To understand this, it is necessary to have a more perspicuous view on catastrophe. A catastrophe is that event, unpredictable when it develops, that indiscriminately involves a group of individuals and inflicts them irreversible or, better, amputating damage. Therefore, it is necessary to build a philosophy of the worst on a philosophy of amputation.
On the existential link of catastrophe and tragedy
Authors: Rivas López Victor G.
Published: August 2023

The main thesis of this dissertation is set out in its very title, and to prove it will be necessary to eliminate the usual negative or melodramatic meaning of the two concepts that appear there and take them rather as the two extremes of the dialectical process of redefining the sociopersonal consciousness. In accordance with this, any catastrophe implies the violent breakup of the normal conditions of existence due to a natural or human factor whose direct consequences each one must understand and overcome on the triple ontological, social, and psychological determinations of the self. For its part, tragedy stands for the phase of critical and reflective integration that follows the catastrophe, which goes a lot beyond the sheer negativity of sorrow and even death, since even if the person or the people carried away by the catastrophe die, others will be able to make the most of that and the sociopersonal consciousness will be rearticulated. Of course, this implies that the self at issue is not only the individual one, so that other members of the lifeworld must be considered for the phenomenon to reveal a new or critical sense of existence beyond any previous approach to it. Thus, although there is an undeniably negativity throughout, it aims at a deeper level of comprehension of existence, which finally implicates that catastrophe is contextualized in a concrete cultural framework and not only as a sudden unsettlement and that tragedy is accordingly conceived as a philosophical tool more than as a literary genre that deals with the cruelty of fate. To get its aims, the dissertation will be divided into three sections of variable length: in the first one it will be analysed the experience and sense of catastrophe; in the second one, that of tragedy; in the third one, it will briefly be shown why understanding the nexus of both phenomena is axial for the current intellectual dynamics.
Pandemonium and postmedia animism
Authors: Bradley Joff Peter Norman
Published: August 2023

In what follows I distinguish «postmodern animism» from my preferred term «postmedia animism», which I propose is a better term to express a minor, virtual, contrarian art and media. In the time of planetary trauma, ecological devastation and collapse, this term will serve as a heuristic concept to trace the passage from pandemic, panic, catastrophe and crisis to the series pandemonium, delirium and the carnivalesque. My gambit is to invoke a rebellious and affirmative Yōkai imaginary (妖怪, ghost, phantom, strange apparition) in order to contest passive forms of «transcendental narcissism» or «transcendental miserabilism».This we shall designate s an aesthetics of existence. In particular, I will analyse the relationship between natural disasters and politics within the Japanese imagination through reference to Namazu-e (鯰絵, woodblock prints depicting catfish), and their political effects in the aftermath of the earthquake of October 1855 (安政江戸地震, Ansei Edo Jishin) in the Edo period of Japanese history (FIG 1). My intention is to show that this historic art form, which grew out of trauma, demonstrates a fabulatory, dissensual and political aesthetics of resistance and creativity. It is an imaginary which appears conspicuously absent in our contemporary moment
The impact of digital skills, human centric culture, employee wellbeing, and HR analytics on talent management in the Sultanate of Oman: A quantitative study
Authors: Al Haziazi Mohammed
Published: August 2023

Talent management is of utmost significance in contemporary organizations striving to navigate the challenges of the current environment effectively. This research aims to explore the perspectives of talent management development practices in the Sultanate of Oman and assess the influence of digital skills, human centric culture, employee wellbeing, and HR analytics on shaping talent management in the region. Employing a quantitative approach, the study was conducted across various organizations in the Sultanate. The findings are based on data collected from a sample of 207 respondents comprising human resource managers from diverse sectors in the Sultanate of Oman, obtained through an online questionnaire using nonprobability sampling. The study substantiates that variables such as digital skills, employee wellbeing, human centric culture, and HR analytics exhibit a significant positive association with talent management, thereby bolstering the mechanisms of talent management within companies in the Sultanate of Oman. These results have immediate implications for talent management practices, ensuring efficient discovery, attraction, development, evaluation, and retention of talented personnel within organizations. As a recommendation, this study proposes that all organizations in the Sultanate of Oman devise a comprehensive list of processes and HR activities to address talent management challenges in the post-COVID era, ultimately enhancing work efficiency and adeptly responding to emerging trends.