bluuebunny/crossref_metadata_2025 huggingface dataset:
NOTA EDITORIAL
Authors: Marinho Rogério Ribeiro , Fernando Diniz Raphael
Published: December 2022

Estimada comunidade acadêmica, é com grande sastifação que publicamos o mais novo número da REVISTA GEONORTE com artigos do segundo semestre de 2022. Entendemos que desenvolver atividades de pesquisa neste período de significativas crises sanitárias, econômicas, políticas e territoriais é bastante desafiador, principalmente pela onda de cortes e bloqueios orçamentários sofridos pelas universidades e agências de pesquisa e pela escalada da violência política pós-eleições.A publicação de trabalhos acadêmicos de alta qualidade é construída com base em um rigoroso processo de revisão por pares. A REVISTA GEONORTE buscar alcançar altos padrões de artigos publicados com a contribuição de nossos revisores. Assim, graças aos esforços dos revisores que trabalharam em 2022, o tempo médio para a primeira decisão foi de 31 dias, enquanto que o tempo médio para a publicação foi de 219 dias. Entre janeiro e dezembro de 2022 a REVISTA GEONORTE recebeu 79 artigos e apresentou uma taxa de aceitação de 48% com taxa de rejeição na entrada de 45%. Os Editores da REVISTA GEONORTE expressam seu apreço e agradecem aos 22 revisores (ver nomes na Nota de Expediente) pelo tempo e dedicação a esta Revista. A REVISTA GEONORTE continua com o propósito de publicar trabalhos inéditos e de qualidade sobre assuntos e temáticas atuais e pertinentes para os estudos geográficos. Esta edição da REVISTA GEONORTE apresenta sete artigos científicos que tratam dos diferentes temas da Geografia e áreas afins, com análises espaço-temporais e abordagens teórico-metodológicas diversas e plurais.
CARACTERIZAÇÃO DAS UNIDADES DE PAISAGEM DA BACIA DO RIO PIRACURUCA (CEARÁ-PIAUÍ)
Authors: De Amorim dos Santos Francilio , Silveira Mendes Lúcia Maria , Brito da Cruz Maria Lucia
Published: December 2022

A pesquisa teve como objetivo realizar o mapeamento e a caracterização das unidades de paisagem da Bacia Hidrográfica do rio Piracuruca (CE-PI), permitindo a análise de suas potencialidades e limitações ao uso. O estudo constitui uma pesquisa descritiva quanto ao seu objetivo e empregou levantamento bibliográfico e cartográfico associado à pesquisa de campo, para mapeamento dos sistemas ambientais. Foram identificadas dez unidades de paisagens que foram agrupados em duas classes de morfogênese, quais sejam: formas de dissecação (platô do Planalto da Ibiapaba, rebordos erosivos parcialmente dissecados do Planalto da Ibiapaba, rebordos erosivos moderadamente dissecados do Planalto da Ibiapaba, rebordos erosivos fortemente dissecados do Planalto da Ibiapaba, depressão monoclinal dissecada, depressão aplainada conservada, interflúvios tabulares, morros e colinas); formas de acumulação (fundos de vales associados à área de inundação, planícies fluviais). Reitera-se que se deve desenvolver o planejamento ao longo da Bacia, cujo planejamento deve pautar-se na gestão das potencialidades e limitações ao uso.
MULTI-SENSOR TECHNIQUES TO FLOOD MAPPING
Authors: Andrade Milena Marília Nogueira de , Brabo Luciana Souza
Published: December 2022

The aim of this article is to map the flooding area in the Tarauacá city of Acre State (Amazon basin, Brazil) using multi-sensor techniques. Floods are the most common disaster in the Amazon, even though flood and risk mapping has only recently been delimited by governmental issues. The methods to flood mapping included Synthetic Aperture Radar (SAR) (Sentinel-1/S1) and optical sensor (Sentinel-2/S2) data, separately, and in a fusion approach. The flood extend was measured on Sentinel-1 VV, on NDWI Sentinel-2, and on unsupervised classification from S1 and S2 fusion and classes: soil exposed, urban, vegetation, shadow, water and clouds. The resulting total areas vary by 8.23 km² (S1), 7.86 km² (NDWI-S2), and 11.87 km² (multi-sensor fusion). The fusion S1S2 results were validated from the calculation of global accuracy (70%), errors of omission (soil exposed 0; urban 31,25; vegetation 87,5; shadow, water and clouds 0), commission errors (soil exposed 50; urban 0; vegetation 75; shadow 6,25, water 6,25 and clouds 87,5), and the kappa index (0.59). Using multi-sensors is an alternative to calculate flood extension and can aid in mapping hydrological hazards in Amazon cities.
Developing Evidence on Water, Sanitation and Hygiene Facilities in the Climate Vulnerable Slums through WASH Poverty Index: A Case Study on Selected Slums in Rajshahi City Corporation, Bangladesh
Authors: Tabassum Tahsin , Fatema-Tuz-Zohora  , Manzoor-Al-Islam Saief , Tahsin Nazwa
Published: December 2022

At present, people worldwide are facing the negative impacts of climate change. On top of that, Bangladesh is one of the most climate vulnerable countries. Many climate migrants from rural vulnerable areas now choosing to seek refuge in slums of cities in Bangladesh. The study has identified the WASH condition of the selected slums in Rajshahi district through WASH poverty index, a multidimensional, WASH-focused, thematic indicator that is also a powerful tool for planning, targeting and prioritizing WASH challenges. Through integrated analysis of WASH and poverty linkages, the index assists to identify key issues which can guiding policymakers towards appropriate action. The index itself is an agglomeration of 3 different indices and few more subindices comprising them. Among those, water poverty index (WPI) accounts for availability, accessibility, water points, use of water and relevant environment. The second indicator, sanitation poverty index (SPI), considers access, capacity, and use. Lastly, hygiene poverty index (HPI) deals with water safety plan, food hygiene, personal hygiene, and domestic hygiene. Weightage of the sub-indices have been determined by literature review and experts’ opinion. The indices and WASH poverty index is measured using the method of multivariative summation and arithmetic mean respectively. While the SPI and HPI both are lowest in the slum named Ashrayan, WPI is the lowest in Char Christan Para. Almost half of the slum dwellers of Char Christan don’t have access to pure water. Interestingly, 67% respondents from all slums using shared toilets, and more than half respondents considered the toilets unhygienic, SPI of all slums are close to zero. Based on the study, people are most likely to maintain hygiene, but to do so is difficult due to economic crisis and lack of service provision. Overall, though Ashrayan has the lowest WASH poverty index, each slum is lagging behind mainly in maintaining a standard level of sanitation facilities and hygiene.
Targeting JunB Induces a Shift of Low- to High-thermogenic Adipocytes and Ameliorates Diet-induced Insulin Resistance
Authors: Zhang Xing , Ding Xiaofeng , Wang Chunqing , Le Que , Wu Dandan , Song Anying , Huang Guixiang , Luo Liping , Luo Yan , Yang Xin , Goins Aleyah , Desai Sharina , Silva Floyd , Feldman Lily , Spafford Michael , Boyd Nathan , Prossnitz Eric , Yang Xuexian , Wang Qiong , Liu Meilian
Published: December 2022

The coexistence of brown adipocytes with low and high thermogenic activity is a fundamental feature of brown adipose tissue (BAT) heterogeneity and plasticity. However, the mechanisms that govern thermogenic adipocyte heterogeneity and its significance in obesity and metabolic disease remain poorly understood. In the current study, we identified a population of JunB-enriched adipocytes (JunB+ adipocytes) within the brown fat depot that exhibits lower thermogenic capacity and smaller lipid droplets compared to high-thermogenic adipocytes. This population of JunB+ adipocytes exhibited marked expansion during obesity, in part through the induction of pro-inflammatory cytokines TNFα and IL-6. Depletion of JunB in adipocytes or UCP1+ adipocytes increased the fraction of adipocytes exhibiting high mitochondrial content and thermogenic capacity, leading to enhanced basal and cold-induced energy expenditure and protection against diet-induced obesity and insulin resistance. Mechanistically, JunB directly binds to the promoter of estrogen-related receptor α (Errα), a downstream effector of PGC1α, and suppresses its transcriptional function. JunB antagonizes the stimulatory effects of PGC1α-ERRα on mitochondrial biogenesis and high-thermogenic adipocyte formation. Taken together, our studies uncover a novel mechanism involving JunB that integrates metabolic and inflammatory signals and shapes the thermogenic adipocyte heterogeneity, serving a critical role in maintaining systemic metabolic health.
On some properties of the compliance-volume fraction Pareto front in topology optimization useful for material selection.
Authors: Duriez Edouard , Charlotte Miguel , Azzaro-Pantel Catherine , Morlier Joseph
Published: December 2022

Selecting the optimal material for a part designed through topology optimization is a complex problem. The shape and properties of the Pareto front plays an important role in this selection. In this paper we show that the compliance-volume fraction Pareto fronts of some topology optimization problems in linear elasticity share some useful properties. These properties provide an interesting point of view on the efficiency of topology optimization compared to other design approaches such as parametric structural optimization. We construct a simple meta-model which requires only one full topology optimization to fit the whole Pareto fronts. Precise Pareto fronts are obtained independently. The fast meta-model constructed has a maximum error of 6.4% with respect to these precise Pareto fronts, on the different problems tested. The selection of the optimal material is then successfully tested on the mass minimization of an MBB beam with an illustrative choice of 4 materials.
Sperm physiology and in vitro fertility outcomes rely on their basal metabolic activity
Authors: Mateo-Otero Yentel , Madrid-Gambin Francisco , Llavanera Marc , Gomez-Gomez Alex , Haro Noemi , Pozo Oscar , Yeste Marc
Published: December 2022

Although looking into the sperm metabolome could help to estimate the reproductive performance, no study has investigated through which mechanisms might sperm metabolism influence fertility outcomes. In this context, the present work sought to interrogate the energy source preferred by pig sperm, as well as the relationship of energetic metabolism with sperm quality, function andin vitrofertilisation (IVF) outcomes. To this end, a targeted metabolomic approach was used to determine the levels of metabolites belonging to glycolysis, ketone bodies and polycarboxylic acids cycle. Here we show that high-quality sperm were associated to greater levels of glycolysis derived metabolites. Additionally, embryo development, but not oocyte fertilisation, was conditioned by sperm metabolic status. Specifically, glycolysis appeared to be the preferential catabolic pathway in sperm giving rise to greater IVF outcomes. This study shows that the basal metabolic activity of sperm influences their function, even beyond post-fertilisation events.
Disrupted topological organization of functional brain networks in traumatic axonal injury
Authors: Li Jian , Shu Yongqiang , Chen Liting , Wang Bo , Chen Linglong , Zhan Jie , Kuang Hongmei , Xia Guojin , Zhou Fuqing , Gong Honghan , Zeng Xianjun
Published: December 2022

Traumatic axonal injury (TAI) may result in the disruption of brain functional networks and is strongly associated with cognitive impairment. However, the neural mechanisms affecting the neurocognitive function after TAI remain to be elucidated. We collected the resting-state functional magnetic resonance imaging data from 28 patients with TAI and 28 matched healthy controls. An automated anatomical labeling atlas was used to construct a functional brain connectome. We utilized a graph theoretical approach to investigate the alterations in global and regional network topologies, and network-based statistics analysis was utilized to localize the connected networks more precisely. The current study revealed that patients with TAI and healthy controls both showed a typical small-world topology of the functional brain networks. However, patients with TAI exhibited a significantly lower local efficiency compared to healthy controls, whereas no significant difference emerged in other small-world properties (Cp, Lp, γ, λ, and σ) and global efficiency. Moreover, patients with TAI exhibited aberrant nodal centralities in some regions, including the frontal lobes, parietal lobes, caudate nucleus, and cerebellum bilaterally, and right olfactory cortex. The network-based statistics results showed alterations in the long-distance functional connections in the subnetwork in patients with TAI, involving these brain regions with significantly altered nodal centralities. These alterations suggest that brain networks of individuals with TAI present aberrant topological attributes that are associated with cognitive impairment, which could be potential biomarkers for predicting cognitive dysfunction and help understanding the neuropathological mechanisms in patients with TAI.
Utilização do Instagram® como estratégia para disseminação de conhecimento acerca da ciência dos alimentos
Authors: SOUTO Laíza Pereira Gonçalves , AYALA Juliana Marciano , LEITE Analy Machado de Oliveira , TEIXEIRA Francisco Martins , LATINI Juliana Tomaz Pacheco , RIVAS Jéssica Chaves
Published: December 2022

As mídias sociais podem ser utilizadas como ferramenta de divulgação de informações. Esse trabalho relata as atividades realizadas pelo projeto de extensão “Farmalimentos”, utilizando o Instagram® como meio de divulgação de conteúdo científico na área de ciência dos alimentos, no intuito de combater as desinformações disseminadas pela sociedade. O projeto é composto por discentes e docentes do curso de Farmácia da Universidade Federal do Rio de Janeiro (UFRJ). Os temas dos posts foram definidos em conjunto, elaborados pelos discentes, sob supervisão dos docentes orientadores. Durante o período de 12 de novembro de 2019 a 02 de setembro de 2021, ocorreram 31 publicações na conta @farmalimentos. Os quadros “Você sabia?”, “Mito ou verdade?” e “Fraudes alimentares” tiveram alcance de 974, 775 e 754 contas, respectivamente. Esperamos ter contribuído para a formação dos estudantes e divulgação de informações fidedignas para população, de forma a auxiliar na escolha por alimentos mais saudáveis e seguros.
Firm-specific investor sentiment and stock price crash risk: The role of foreign investors in Korea’s stock market
Authors: Shin Heejeong , Choi Su-Young
Published: December 2022

Building on a prior study that documents that stock price crashes are positively associated with firm-specific investor sentiment (hereafter, the sentiment), this study further investigates the moderating effect of foreign investors on Korea’s stock market. This study hypothesizes that foreign investors as sophisticated participants are indifferent of the significant relationship between the sentiment and the stock price crashes. For firms listed on the KSE over the period of 2011–2019, the analysis findings show that the high stock crash risk attributable to the high sentiment is attenuated for firms with high foreign ownership. However, such moderating effect of foreign ownership disappears when taking foreign investment horizon into consideration. This implies that future stock crash risk reduction under the high sentiment is due to the corporate monitoring role of foreign investors, who are targeting a long-term investment horizon. This study adds to the literature on the role of foreign investors by suggesting that foreign investors act as a rigorous monitor helpful for managing stock price, rather than a price maker who is rational under the high sentiment.
Application of PID controller in chemical process system using COMSOL
Authors: Ulkir Osman , Ertugrul Ishak
Published: December 2022

Process control covers the analysis, design, and application of control systems to achieve specific objectives in process safety, production capacity, and product quality. Control of any system is significant, especially in chemical process systems. For this, it is necessary to use a control that can meet the system's demands and work harmoniously. In this study, a system that can be adapted to the chemical process industry has been designed and modelled in the COMSOL program. The concentration level and velocity behaviour of the same type of fluid applied from two channels over this model were kept at the desired level with the Proportional Integral Derivative (PID) control algorithm. The flow rate of the fluids can be changed with the controller to achieve the desired concentration. As a result of the simulation with different PID coefficients, the best response was obtained when the high proportional gain coefficient was applied. It has been determined that the best response of the process in both concentration and velocity data is achieved when kp= –1 m4/(mol·s). A high overshoot and steady-state error occurred at low proportional gain values in the system response.
Gelecek Müzelerinde İç Mekân Biçimlenişi: T.um Müzesi Örneği
Authors: Yıldırım Burcu , Aytıs Saadet
Published: December 2022

Toplumların sanatsal, kültürel ve sosyal birikimlerinin tarihsel süreçte izlenebilmesine imkân veren müze olgusu, geçmişten bugüne sürekli bir değişim ve dönüşüm içerisindedir. Bu durumun bir sonucu olarak bugün müzeler farklı başlıklar altında çeşitlenmektedir. Yapılan araştırmada giderek yaygınlaşmakta olan gelecek müzelerinin iç mekân tasarımlarının anlamsal ve biçimsel boyutunun bir analizinin sunulması, kültürel ve sosyolojik etkilerinin değerlendirilmesi ve misyonlarının bir getirisi olarak gerçekleştirdikleri geleceğin iç mekânlarını öngörme durumunun incelenmesi amaçlanmaktadır. Literatür taraması ve örnek olay incelemesi yaklaşımlarının benimsendiği araştırma kapsamında Kore’nin Seul şehrinde yer alan ve ait olduğu telekomünikasyon firmasının geleceğin teknolojilerine yönelik yaklaşımını uzamsal boyutta temsil eden T.um Müzesi incelemeye uygun bulunmuştur. Bu tür müzelerde müze mekânlarının ziyaret deneyimini hikâyeleştirecek bir kompozisyonda kurgulandığı ve geçici sergilerle müze esnekliğinin desteklendiği, çağdaş müzelerin eseri ön plana çıkaran yalın mekân tasarımları tutumunun yadsınarak mekânların ön plana çıkarıldığı ve uzamın nesneleşerek sergilenen asıl unsur haline dönüştüğü bulgulanmıştır.
Romare Bearden’ın Kolaj Eserlerinde Kültürel Deneyimin İzini Sürmek
Authors: Şenel Elif
Published: December 2022

Sanat, tarihin belirli dönemlerinde, ana akımın dışında kalmış halkların kaygılarına istinaden kültürel ve toplumsal bağlamlar üzerinden anlamlandırılmıştır. Yirminci yüzyılda, Afro-Amerikalıların sosyo-kültürel mücadelesinin sanatta yarattığı etki bunu örneklemiştir. Afro-Amerikan sanatçı Romare Bearden, dönemin kültürel ortamında öne çıkan isimler arasında dikkat çekmiştir. Sanatçının, siyahi kültürün ve Afro-Amerikan deneyimin anlatım olanaklarını sergilediği kolajları hem içerik hem de biçim açısından sıra dışı bulunmuştur. Araştırmada Romare Bearden’ın kolajlarında kültürel deneyimin izini sürmek amaçlanmıştır. Araştırma yöntemi kapsamında doküman analizi yapılmıştır. Referans alınan veriler konu bağlamında objektif olarak betimlenmiştir. Sanatçının bazı eserleri analiz edilerek konu detaylandırılmıştır. Araştırmanın sonucunda, Bearden’ın, Afrikalı köklerden Afro-Amerikan kültüre uzanan toplumsal belleğin anlatıları olan kültürel kolajlarının özgün yapısına dikkat çekilmiştir. Ayrıca bu kolajların, döneminin ötesinde bir sınırsızlık sergilediğine vurgu yapılmıştır.
Batı Sanatında Divanda Uzanmış Beden İmgesi
Authors: Örgel Sevtap
Published: December 2022

Antik Yunan’dan günümüze dek pek çok formda üretilmiş olan “Divanda uzanmış Beden” betimlemesi görsel hafızamızda oldukça geniş bir yere sahiptir. Araştırma kapsamında, Avrupa düşün ve sanat tarihi mekânsal ve dinsel dönüşümler çerçevesinde incelenmiş, elde edilen teorik veriler ve mekânı divana, bedeni nüye bağlayan sanatsal üretimler aracılığı ile “Divanda Beden” imgesinin postmodern dönem öncesi sanata yansımaları incelenmiştir. Sanat tarihi okumaları ve daha dar perspektifte “Hristiyanlık öncesi ve sonrası toplum” araştırmalarında karşımıza sıkça çıkan bu betimlemenin, bedenin ve uzamın geçirdiği dönüşümden bağımsız ele alınamayacağı bulgusuna ulaşılmıştır. “Beden ve çıplaklık”, “uzanma ve divan” kavramlarını birlikte düşündüğümüz noktada, kutsal beden, günahkâr beden, çıplaklık, kadının konumu ve özel alanın kavranışındaki değişimler üzerinde durulması gereken mecburi duraklar olmuştur. Araştırma, karikatürize edilerek psikanaliz yatağı imgesine indirgenmiş olan divanın, farklı bir bakış açısıyla, sanatsal üretimde “Bedeni odaklayan uzam” olarak kullanımına dair sanat literatürüne bir yorum sunmayı hedeflemektedir.
ARTISTA-MEMÓRIA
Authors: MENDES SOUZA ANA TEREZA
Published: December 2022

Este presente artigo propõe uma reflexão sobre a relação do artista, em particular, os fazedores da arte teatral, e suas potencialidades frente à onda negacionista que vem se alastrando no Brasil e que aniquila a identidade de sua nação. Logo, paralelamente, este trabalho discorre também sobre o valor que a memória, e a história, possuem sobre a construção da identidade de um indivíduo e, intrinsecamente, de um povo. Neste contexto, surge o artista-memória, fruto de uma ideia desenvolvida a partir da pesquisa de mestrado em Artes Cênicas, aprofundando o pensamento sobre as marcas e transformações que a arte pode produzir neste contexto atual. Tendo como referencial teórico as ideias do sociólogo Maurice Halbwachs, num diálogo com os pensamentos contemporâneos de Michael Pollak, além das contribuições do historiador Pierre Nora, no que tange, principalmente, o conceito de “homem-memória”, o artista-memória é a reafirmação de que é preciso olhar para o passado, para as memórias, com o objetivo não só de entender o presente, mas bem como criar, conscientemente, o futuro.
Territórios teatrais a partir das máscaras brincantes
Authors: Gomes Vanéssia
Published: December 2022

Este artigo trata sobre as máscaras teatrais presentes nas manifestações tradicionais populares. Trago como questão demarcadora desenvolver um pensamento que apresente as manifestações tradicionais como lugar de referência para os estudos e práticas de procedimentos de atuação teatral.  Associo a este pensamento as experiências criadas e executadas por brincantes, mestras e mestres que partem de práticas cênicas construídas e repassadas entre si, e entre grupos. Intento colaborar com artistas/pesquisadores(as) de teatro que tomam como referência estas práticas para suas criações, resultando em diversos tipos de aproximações, diálogos, encontros e similitudes. Proponho a articulação de matrizes que possam ser deflagradoras de novos campos de investigação a partir da cena popular. Estas inquietudes emergem do meu trabalho, como atriz e diretora, desde os processos de pesquisa e criação que dei início no princípio dos anos 90, onde também ocorre minha aproximação a estas expressões. Destaco nesta trajetória os espetáculos e as investigações desenvolvidas como integrante do Grupo Teatro de Caretas (CE).
Pedagogias da máscara em crise: riso e aberturas dramatúrgicas
Authors: Achcar Ana
Published: December 2022

O artigo que aqui apresento explora a máscara teatral enquanto lugar de passagem e os efeitos decorrentes da crise que esse trânsito pode provocar entre o ator e a sua própria atuação. A passagem como instância de crise, a crise como sinal de abertura, um convite para mover-se de si e ir na direção do outro, essa expansão como terreno para a empatia e a comunicação da cena. Para isto tomo como referência algumas experiências pedagógicas de formação de palhaços desenvolvidas nos cursos e ensaios conduzidos por mim na Escola de Teatro da Universidade Federal do Estado do Rio de Janeiro (UNIRIO) onde sou docente desde 1994, e um exercício de criação de personagem experimentado por mim no processo de ensaio da performance teatral A plebe de Coriolano, realizada em 2022 no Rio de Janeiro.
Czy zaburzenie osobowości typu borderline może stanowić przyczynę nieważności małżeństwa kanonicznego? Analiza w oparciu o orzecznictwo Roty Rzymskiej
Authors: Olejnik Bogumiła
Published: December 2022

Zaburzenie osobowości typu borderline jest jedną z dysfunkcji psychicznych powodujących niezdolność do dobrowolnego zawarcia małżeństwa kanonicznego. Jest to zaburzenie trudne do zdiagnozowania, a jednocześnie coraz częściej występujące w po- pulacji. Z tego powodu wątki związane z występowaniem zaburzeń z pogranicza obecne są również w praktyce sądów kościelnych. Przedmiotem analizy w niniejszym artykule jest orzecznictwo Roty Rzymskiej w sprawach o nieważność małżeństwa z powodu wad zgody małżeńskiej, które spowodowane były występowaniem osobowości z pogranicza. Analizowane wyroki pochodzą z lat 1983-2020. Celem analizy jest ukazanie orzecznictwa Roty Rzymskiej, które ma mieć praktyczne zastosowanie dla sądów niższych instancji przy orzekaniu w sprawach, w których jedna ze stron procesowych ma zaburzenia graniczne.
Biegły w sprawach o nieważność małżeństwa spowodowanych zaburzeniami nastroju – trzy objaśnienia
Authors: Nowakowski Bartosz
Published: December 2022

W artykule omówiono trzy aspekty roli biegłego w sprawach o nieważność małżeństwa spowodowanych zaburzeniami nastroju, a więc kwestię wzajemnej relacji procesowej sędzia-biegły, kwestię obligatoryjności opinii biegłego oraz zakres działań biegłego sądowego, pozasądowego i biegłego prywatnego.
Płaszczyzny odpowiedzialności genetycznej a rola rodziców
Authors: Morciniec Piotr
Published: December 2022

Nieosiągalny wcześniej rozkwit badań genetycznych, zwłaszcza po finali- zacji Projektu Sekwencjonowania Genomu Ludzkiego, stawia współczesną naukę, ale i społeczeństwo przed nowymi wyzwaniami. Jednym z istotnych jest określenie statusu uzyskiwanych w ramach tych badań informacji genetycznych. Niniejsze badania do- tyczą formułowanego coraz częściej nakazu wymogu odpowiedzialności genetycznej w kontekście zadań rodzicielskich. Celem badań było wskazanie płaszczyzn takiej od- powiedzialności i konsekwencji wprowadzania jej w życie. W badaniach zastosowano metodę naukową desk research, a więc analizę danych zastanych, z uwzględnieniem dostępnych dokumentów, badań i publikacji, oraz ich konfrontację z normami bioe- tyki personalistycznej. Osiągnięte wyniki potwierdzają zarówno zmianę paradygmatu w podejściu do zdrowia, jak i poważne konsekwencje stosowania norm określanych jako odpowiedzialność genetyczna, jeśli zostaną one zaaplikowane do funkcjonowania rodziny w zakresie przekazywania życia, gospodarowania pozyskaną informacją genetyczną czy zarządzania ryzykiem genetycznym.
Threats to the institution of marriage in letters and messages of the Polish bishops in 1918-1939
Authors: Kantor Robert
Published: December 2022

Niniejszy artykuł podejmuje temat zagrożeń instytucji małżeństwa widzianych przez biskupów polskich w latach 1918-1939. W okresie dwudziestolecia międzywojennego biskupi czuwali nad czystością nauki o małżeństwie i byli wyczuleni na pojawiające się zagrożenia dotyczące tej instytucji. Stąd też w opracowaniu zostanie zaprezentowane nauczanie biskupów w listach pasterskich i odezwach, najpierw na temat świętości mał- żeństwa, a następnie zostaną omówione zagrożenia w postaci ślubów cywilnych, roz- wodów, małżeństw mieszanych, czy błędnie pojmowanego świadomego macierzyństwa.
Afirmación de la vida a través de la política: una aproximación al concepto de acción-política en Hannah Arendt
Authors:   Universidad de Santiago de Cali, Cali, Colombia, Domínguez Héctor , Grueso Grueso José Rosario ,   Universidad de Santiago de Cali, Cali, Colombia
Published: December 2022

En este artículo se examina la influencia que ejerce la violencia en la construcción del Estado. Asimismo, desde la perspectiva de Hannah Arendt, se analiza la política como espacio donde se afirma y protege la vida a través de la acción política y las normas jurídicas. Se trata de razonar el dualismo política-violencia, y violencia-normas jurídicas. En este sentido, la pregunta que da origen al presente escrito se enuncia en los siguientes términos: ¿cómo es posible reafirmar la vida como voluntad a través de la política y cuidar de la existencia humana en un contexto en donde la violencia pareciera ser consustancial a la forma de estado y al medio por el cual se construye la comunidad política? Un examen riguroso de las circunstancian que fuerzan el análisis de este interrogante conduce necesariamente a sostener que: solo se podrá afirmar la vida a través del ejercicio de la política, cuando la sociedad política sea concebida como una construcción institucional cuya meta principal sea combinar la libertad de los individuos y las colectividades con la unidad de las normas jurídicas.
La ‘Declaración’ en la doctrina del derecho de La metafísica de las costumbres
Authors:   Universidad de Chile, Santiago, Chile., Ticchione Sáez Diego
Published: December 2022

La ‘declaración’ es uno de los momentos constitutivos de la adquisición de una propiedad (AA 6 258). Este momento debe verse satisfecho si es que dicha adquisición ha de volverse real, sin importar las condiciones empíricas bajo las que tal objeto sea adquirido, ni tampoco el objeto del que se trate (AA 6 251-254, 273). No obstante, teniendo en consideración que la presentación de los attendenda —entre los que la declaración se halla— es posterior a la exposición de los objetos que le son apropiables a nuestro arbitrio (cf. AA 6 247-248), podría pensarse que dichos momentos sufren de algún condicionamiento para su posibilidad en referencia al tipo de objeto que vaya a ser adquirido, o bien, que son estos los que resultan condicionados por ellos. Más aún, en la medida en que toda ‘declaración’ demanda una ejecución, su pretendido estatuto trascendental queda puesto en tensión. No obstante, se mostrará que dicha tensión se resuelve atendiendo a (1) que la procedencia de toda ‘declaración’ es la comunidad originaria, y (2) que la ‘declaración’, fundada en la comunidad originaria, es un acto de habla que no modifica la naturaleza de dicha comunidad.
Realismo ingenuo e intencionalismo: un camino intermedio en busca de una relación interpretativa con el entorno
Authors:   Universidad Alberto Hurtado, Santiago, Chile., Díaz García Maximiliano
Published: December 2022

En filosofía de la percepción el relacionamiento con el entorno es el terreno donde el Realismo Ingenuo y el Intencionalismo se posicionan como dos posturas contrarias. La primera de ellas presenta una explicación que satisface al que busca un esclarecimiento del relacionamiento íntimo en la presentación del entorno durante la percepción, mientras que la otra teoría podría satisfacer a aquellos que buscan un esclarecimiento de la manera en la cual el entorno se presente de tal o cual modo a diferentes percipientes, dando espacio para la formación de juicios y creencias particulares. Pero ¿podrá existir un planteamiento intermedio que asegure la intimidad de la presentación perceptual y la representación del entorno? El siguiente articulo expondrá los elementos del debate abordando una definición de cada teoría, luego avanzando hacia una alternativa intermedia y, finalmente, concluyendo de la posibilidad de tal postura intermedia, pero con un enfoque representacional dinámico.
Synthesis of Piperidine Conjugated Quinoxalines as Potential Antibiofilm Agents
Authors: Shruthi Jeegundipattana B. , Kiran Kuppalli R. , Gunashree Kodagahally T. , Divyashree Shivakumar , Sreenivasa Marikunte Y. , Sadashiva Maralinganadoddi P. , Rangappa Kanchugarakoppal S.
Published: December 2022

Background:

The most common cause of food-borne illness is bacterial or viral contamination.
Although there are several therapeutics available to combat these microbes, they lost their efficacy in
long-term medication. Because, over a period of time, microbes developed resistance against drugs and
this antimicrobial resistance is a serious threat to global public health as a consequence of the widely disseminated
and careless use of antimicrobials. Therefore, there is a need to develop some new chemical
moieties with a safety factor and better efficacy. A series of substituted N-(1-benzylpiperidin-4-
yl)quinoxalin-2-amines (5a-j) (5ab, 5ac) were synthesized and screened for their in vitro antibacterial
activity against Salmonella paratyphi, a well-known food-borne pathogen.

Methods:

Experimental methods, agar diffusion and broth microdilution assays were carried out to evaluate
the antibacterial activity of the lead compounds. Further, antibiofilm methods, crystal violet, and MTT
assays were subjected to investigate their biofilm inhibition capacity against S. paratyphi.

Results:

Among the tested compounds, 5b, 5e, 5h, and 5j bearing 4-chloro, 3,4-dimethoxy, 4-methyl and
thienyl groups on the phenyl ring of quinoxalines emerged as potential candidates having significant antisalmonella
activity. In these four potential candidates, compounds 5b and 5h were effective against Salmonella
whereas compounds 5e and 5j effectively inhibited the biofilm formation of Salmonella.

Conclusion:

N-(1-benzylpiperidin-4-yl)quinoxalin-2-amines (5a-j) (5ab, 5ac) were synthesized and evaluated
for antisalmonella activity against S. paratyphi. Among the series of compounds, four compounds
significantly showed good activity and emerged as antibacterial agents for further studies in the future.
Synthesis and Anticancer Activity of Novel Chromene Derivatives,
Chromeno[2,3-d][1,3]Oxazines, and Chromeno[2,3-d]Pyrimidines
Authors: Yousif Mahmoud N.M. , Fathy Usama , Yousif Nabil M.
Published: December 2022

Background:

Several chromene derivatives have a wide variety of biological and pharmacological
activity. They had anticancer activity, antimicrobial activity, antituberculosis activity, anticonvulsant
activity, antidiabetic activity, antichlolinesterase activity, and inhibitor of monoamine
oxidase activity. The above-mentioned activities directed us to synthesize novel chromene derivatives,
chromeno[2,3-d][1,3]oxazines, and chromeno[2,3-d]pyrimidines. The starting material was 2-
amino-8-(2-chlorobenzylidene)-4-(2-chlorophenyl)-5,6,7,8-tetrahydro-4H-chromene-3-carbonitrile.

Methods:

Several novel chromene derivatives had been synthesized. Compound 1 reacted with carbon
disulfide, and ethyl chloroformate to afford chromene derivatives 2, 3. Chromene derivative 3
reacted with hydrazine dydrate to give compound 4. Chromene derivative 1 reacted with acetic acid
and sulphuric acid to produce compounds 5, and 6. Amino derivative 5 reacted with chloroacyl derivative
to afford compounds 7a-c which cycalized in dry xylene to afford compounds 8a-c.
Chromene derivative 8a reacted with hydroxyl amine to afford compound 9.

Results:

The structures of novel synthesized chromene derivatives had been confirmed using mass
spectroscopy, infrared spectroscopy, nuclear magnetic resonance spectroscopy, and elemental analysis.
Most of the prepared compounds were screened against liver cancer cell lines (HepG-2), human
colon cancer cell lines (HT-29), and breast adenocarcinoma cell lines (MCF-7). Chromene derivative
2 had anticancer activity against human colon cancer cell lines (HT-29) higher than the reference
drug doxorubicin. The rest of the tested compounds had anticancer activity against human colon
cancer cell lines (HT-29) lower than that of the reference drug doxorubicin. Chromene derivative 5
had anticancer activity against liver cancer cell lines (HepG-2) higher than the reference drug doxorubicin.

Conclusion:

Several chromene derivatives had been synthesized and their structures had been confirmed
using different spectroscopic techniques. Some of the chromene derivatives that were
screened against different cancer cell lines showed promising anticancer activity higher than the reference
standard drug. For example, chromene derivative 2 had anticancer activity against human
colon cancer cell lines (HT-29) higher than the reference drug doxorubicin. Chromene derivative 5
had anticancer activity against liver cancer cell lines (HepG-2) higher than the reference drug doxorubicin.
Chromene derivative 6 had anticancer activity against breast adenocarcinoma cell lines
(MCF-7) higher than the standard drug.
Relation between Apolipoprotein E in Alzheimer’s Disease and
SARS-CoV-2 and their Treatment Strategy: A Review
Authors: Ramachandran Anu Kunnath , Das Subham , Shenoy Gurupur Gautham , Mudgal Jayesh , Joseph Alex
Published: December 2022

COVID-19, which primarily affects the pulmonary system, turned out to be a global pandemic,
whereas the effects on other systems are still unknown. SARS-CoV-2, binds to angiotensinconverting
enzyme 2 (ACE2) receptors in the lungs, causing pneumonia-like symptoms. The same
ACE receptors are also present in organs other than the lungs. Therefore, there is a need to study the
impact of coronavirus on other human body organs. Recently, UK Biobank reports on the genetic risk
factor of the virus attack. A double mutation in the apolipoprotein E (APOE4) allele has shown a significant
role in COVID-19. The same APOE4 mutation has already been proven to hold a key role in
developing early-onset Alzheimer’s disease (EOAD). Despite this data, Alzheimer’s disease is believed
to be a comorbidity of COVID-19. Previous virus attacks on the same viral family, Coronaviridae,
produced neurological effects like neurodegeneration, neuronal inflammation, and other central
nervous system-related dysfunctions. Since the long-term implications of COVID-19 are unknown,
more research into the impact of the virus on the central nervous system is needed. Both COVID-19
and AD share a common genetic factor, so that AD patients may have a greater risk of SARS-CoV-2.
Here, in this review, we have briefly discussed the role of APOE4 in the pathogenesis of AD and
SARS-CoV-2, along with their treatment strategy, current scenario, and possible future directions.
Detection and Classification of the Different Stages of Alzheimer’s Disease using Sequential Convolutional Neural Network
Authors: Prakasam P , Gnanavel Aakash , Rajendran Karnan , Suresh Sailesh
Published: December 2022

Background

Alzheimer's disease (AD) is a degenerative disorder known as mild or significant neurocognitive impairment diagnosed in older people and significantly reduces their quality of life. Memory issues are regularly one of the principal indications of Alzheimer's disease; however, beginning manifestations may vary from one individual to another. Detecting Alzheimer's disease is a time-consuming and challenging task but requires brain imaging reports and human expertise.

Objective

More accurate and early diagnosis is essential for timely treatment and risk reduction. The accurate diagnosis of Alzheimer's disease plays an essential role in inpatient treatment, especially at the disease's early stages, because risk awareness allows the patients to undergo preventive measures even before the occurrence of irreversible brain damage. The main objective of this research is to diagnose Alzheimer's disease in its early stage through Magnetic Resonance Imaging (MRI).

Methodology

To detect and classify the various stages of Alzheimer’s disease from the MRI, a Sequential Convolutional Neural Network (S-CNN) model is proposed, which incorporates the advantage of convolution operation and recurrent operation.

Results

The combination of Alzheimer's Disease Neuroimaging Initiative (ADNI) dataset and the Open Access Series of Imaging Studies (OASIS) dataset obtained from the Kaggle is used for training and testing the proposed S-CNN model.

Conclusion

The baseline DenseNet169 model has been fine-tuned and added sequentially to achieve better validation accuracy. From the validation, it is observed that it achieves an accuracy of 88.60% and outperforms other reported methods.
WITHDRAWN: Effect of Reiki Therapy on Pain, Depression, and Quality
of Life in Hospitalized Cancer Survivors: A Pilot Study
Authors: Pattanshetty Renu B , Ahmed Imtiaz , Deshpande Renuka Rajendra
Published: December 2022

The article has been withdrawn at the request of the authors of the journal "Current Traditional Medicine".

Bentham Science apologizes to the readers of the journal for any inconvenience this may have caused.

The Bentham Editorial Policy on Article Withdrawal can be found at https://benthamscience.com/editorial-policies-main.php

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of their article is transferred to the publishers if and when the article is accepted for publication.
Analisis Kekeringan Meteorologi dengan Metode Standardized Precipitation Index (SPI) dan China Z Index (CZI) Di Sub DAS Kadalpang, Kabupaten Pasuruan
Authors: Dewita Monika , Harisuseno Donny , Suhartanto Ery
Published: December 2022

Sub DAS Kadalpang, Kabupaten Pasuruan merupakan salah satu daerah rawan bencana kekeringan di Indonesia. Analisis kekeringan serta pemetaan sebarannya diperlukan sebagai upaya meminimalisir dampak kekeringan. Studi ini bertujuan untuk mengetahui hasil kesesuaian metode Standardized Precipitation Index (SPI) dan China Z Index (CZI) dengan Southern Oscillation Index (SOI) sehingga didapatkan metode yang lebih sesuai diterapkan pada Sub DAS Kadalpang. Pemetaan sebaran kekeringan menggunakan metode Inversed Distance Weight (IDW) dengan bantuan Sistem Informasi Geografi bertujuan untuk mengetahui daerah terdampak secara lebih akurat agar penanganan dapat dilakukan dengan optimal. Hasil indeks kekeringan terparah metode SPI sebesar (-3,711) pada periode 1 bulan, pada bulan Mei 2018. Hasil indeks kekeringan terparah metode CZI sebesar (-6,701) pada periode 1 bulan, pada bulan Mei 2018. Analisis korelasi CZI dan SPI dengan SOI menunjukkan hubungan linier yang lemah. Dipilih opsi perbandingan dengan pola curah hujan untuk menunjukkan kesesuaian dengan lokasi studi dan metode CZI lebih sesuai. Penggambaran peta sebaran kekeringan menggunakan metode yang lebih sesuai yaitu CZI. Hasil peta sebaran kekeringan dengan jumlah kejadian kekeringan terparah tahun 2007 dengan bulan kering terparah bulan Mei, dan terdapat 17 desa di Sub DAS Kadalpang berpotensi terdampak kekeringan sehingga perlu diprioritaskan dalam upaya mitigasi bencana kekeringan di masa mendatang.
Perencanaan Jaringan Distribusi Air Bersih di Perumahan Grand Arfa Wulandira Kabupaten Serang dengan Aplikasi WaterCAD CONNECT Edition
Authors: Amrul Muhammad Alfarisy , Haribowo Riyanto , Sholichin Moh.
Published: December 2022

Perumahan Grand Arfa Wulandira merupakan sebuah perumahan yang terletak di Desa Wanayasa, Kecamatan Kramatwatu, Kabupaten Serang. Pada perumahan ini terdapat satu buah sumur bor, akan tetapi belum terdapat sebuah jaringan distribusi air bersih untuk memenuhi kebutuhan penduduknya. Dengan demikian, perlu diadakan perencanaan jaringan distribusi air bersih di Perumahan Grand Arfa Wulandira meliputi aspek hidrolika, kualitas air dan ekonomi. Dalam perencanaan jaringan air bersih, dilakukan dengan aplikasi WaterCAD CONNECT Edition untuk simulasi dan pemodelan kondisi hidraulik jaringan air bersih. Untuk perhitungan biaya dan analisa ekonomi dilakukan secara manual berdasarkan Permen PUPR No. 28/PRT/M/2016. Dari hasil analisa hidrolis, menunjukkan hasil perencanaan memenuhi kriteria jaringan perpipaan pada Permen PUPR No. 18/PRT/M/2007. Hasil dari perencanaan ini adalah kecepatan sebesar 0,10 m/det – 2,39 m/det, headloss gradient sebesar 0,13 m/km – 14,80 m/km dan tekanan sebesar 1,83 atm – 2,87 atm. Hasil analisa ekonomi menunjukkan biaya perencanaan sebesar Rp1.292.830.000,00 dengan penentuan harga air sebesar Rp1.667,22/m3.
Studi Evaluasi Kebutuhan Air Irigasi dan Penyusunan Jadwal Pembagian Air pada Daerah Irigasi Nglirip Kabupaten Tuban
Authors: Farid Mochammad Nur Fahrudin , Sayekti Rini Wahyu , Ismoyo M. Janu
Published: December 2022

Daerah Irigasi Nglirip memiliki luas baku sawah sebesar 1292 hektar. Permasalah yang terjadi pada Daerah irigasi Nglirip adalah kekurangan air pada musim kemarau dan debit sungai berlebih ketika musim penghujan. Penelitian ini bertujuan untuk mengevaluasi kebutuhan air irigasi menggunakan metode Water Balance, kemudian direncanakan pola tata tanam rencana untuk meningkatkan intensitas tanam ketika debit air berlebih dan merencanakan jadwal pembagian air rotasi menggunakan faktor K. Dari studi ini didapatkan besarnya debit andalan maksimum sebesar 2695,57 lt/dt dan minimum 485,64 lt/dt, Luas intensitas tanam eksisting sebesar 274,94% dan rencana 275%, dari neraca air eksisting terjadi defisit air sebanyak 19 kali dan surplus air 17 kali sedangkan dari neraca air rencana terjadi 19 kali defisit dan 17 kali surplus air dari 36 kali periode tanam, pembagian air rotasi dengan faktor K(0,25-0,5) sebanyak 9 kali, faktor K (0,5–0,75) 7 kali, dan Faktor K > 0,75 20 kali.
Prediksi Laju Infiltrasi Berdasarkan Sifat Porositas Tanah, Distribusi Butiran Pasir, dan Lanau
Authors: Bachtiar Yusra Syarifah , Harisuseno Donny , Fidari Jadfan Sidqi
Published: December 2022

Laju infiltrasi suatu wilayah memiliki karakteristik dinamis menyesuaikan keadaan terbaru wilayah terkait. Dengan tingginya tingkat pengembangan wilayah zaman ini, maka pembaruan akan laju infiltrasi secara berkala harus dilakukan. Karakteristik laju infiltrasi suatu wilayah sangat dipengaruhi oleh sifat fisik tanah, salah satunya ialah sifat porositas tanah dan distribusi butiran. Studi ini akan merumuskan sebuah model prediksi laju infiltrasi berdasarkan hubungannya dengan sifat porositas tanah, distribusi butiran pasir, dan lanau. Perumusan model prediksi akan memanfaatkan analisis regresi berganda dan analisis asumsi klasik untuk membuktikan bahwa persamaan yang terbentuk layak untuk digunakan atau memenuhi BLUE criteria. Kemudian, dilakukan analisis validasi untuk menggambarkan tingkat error model prediksi yang dimiliki. Berdasarkan pengolahan data yang telah dilakukan, dapat disimpulkan bahwa persamaan yang terbentuk memenuhi BLUE criteria mengacu pada hasil analisis asumsi klasik. Di sisi lain, model prediksi juga dinilai memiliki tingkat kesalahan prediksi yang rendah dengan hasil perhitungan nilai NSE=0,0,84, RMSE=1,13, r=0,792 dan R2 masing - masing 63 %, 76 %, 63 % untuk porositas tanah, distribusi butiran pasir, dan lanau.
Analisis Hidrolis Uji Model Fisik Bendung Mena Kabupaten Timor Tengah Utara
Authors: Kianendra Reza , Ismoyo M. Janu , Prayogo Tri Budi
Published: December 2022

Bendung Mena merupakan salah satu infrastruktur untuk mengatasi masalah pemenuhan kebutuhan air irigasi daerah mena, sebagai suatu upaya konservasi sumber daya air. Rehabilitasi Bendung Mena diadakan untuk menambah intake agar memperluas daerah irigasi seluas 820 Ha. Tujuan penelitian ini untuk memberikan gambaran tentang pola aliran hidrolika pada desain Bendung Mena dan kemampuan pembilasan kantong lumpur pada intake kanan yang terjadi pada model test. Hasil penelitian menunjukan kondisi hidrolis aliran subkritis dengan beberapa section superkritis pada bagian pelimpah. Gerusan pada model sedalam 0,016; 0,021; dan 0,022 meter. Pintu intake mampu mengalirkan kebutuhan irigasi dan pembilasan. Perhitungan kemampuan pembilasan kantong lumpur menggunakan grafik regresi dari hasil pemodelan menghasilkan debit pembilasan sebesar 4,1 m3/dt dengan kemampuan pengangkutan sedimen 75,39% dari total sedimen. Penelitian ini diadakan dengan harapan hasil pemodelan hidrolika dapat lebih berkembang dalam menentukan desain bendung dan perencanaannya dapat dipermudah.