bluuebunny/crossref_metadata_2025 huggingface dataset:
Mining enterprises innovativeness from the point of view of human capital significance
Authors:   Ural State Mining University, Komarova Oksana , Strovskii Vladimir E. ,   Ural State Mining University, Peregon Irina V. ,   Ural State Mining University
Published: October 2020

Research relevance. Today, the main prerequisite for the improvement of mining enterprises performance and competitiveness is their transition to innovation-based development. The enterprises are directed towards the novelties, innovations, and changes, which largely depend on human activity revitalization. As a result, human capital becomes more valuable than metal, oil, etc. Human capital becomes exactly the value that determines the economic development. Innovation-based development of a mining enterprise is the influence exerted by the managing entity on the managed enterprise with the purpose of transferring it to the required state. The effectiveness of mining enterprise innovative development management requires appraising the level of innovativeness and taking necessary remedial actions in order to achieve the goals. Research aim is to develop the methodological apparatus of estimating the innovativeness of a mining enterprise based on the development of human capital. Results. In the course of the research the need to switch to the innovation-based development has been justified, the special role in its realization is played by the effective use of the innovative potential. In its turn, human capital is the fundamental component of the innovative potential; human capital development conditions the enterprise’s assignment to an innovative type. Methodological apparatus of estimating the innovativeness has been worked out, which provides for the estimation of the innovative character of technical and process transformations, innovative product and innovative human capital. End appraisal ratio is an integral indicator formed based on four indices with the account of the weighting factors. It is recommended to establish the threshold values of the integral indicator which will make it possible to differentiate mining enterprises according to the level of innovative development. In order to estimate the human capital, the author’s recommendations published later should be referred to. Summary. The use of the methodological apparatus of estimating innovative mining enterprises will make it possible to increase the effectiveness of managing the process of switching to the innovation-based development. Control over the variation of innovativeness level makes it possible to take necessary remedial actions and achieve the desired condition.
Telescoping hydraulic cylinder loading during boom equipment rotation
Authors:   Emperor Alexander I St. Petersburg State Transport University, Potakhov Egor
Published: October 2020

Introduction. Currently, hydraulic equipment for telescopic boom equipment is widely used as working equipment for road, construction, hoisting-and-transport and mining machines. However, not all sides of the dynamic loading of the telescoping hydraulic cylinder have been studied. Research aim. The aim of the work is to study the loading of the telescoping hydraulic cylinder (MTC) taking into account the interaction with the telescopic boom during normalized rotation of the boom equipment and during subsidence of the supporting surface of the hoisting machine during the rotation of the working equipment. Methodology. To study the dynamic loading of the MTC, numerical modeling is carried out in the environment of the specialized Motion functional (complex dynamic and kinematic module) of the SolidWorks software package and the SolidWorks Simulation finite element calculation module. Results. The nature of the loading of the MCP elements was established: the time dependences of the angular displacements of the pistons, as well as the forces of counteraction of the shelves of the sections with the MTC, the walls of the sections with the trunnions of the MTC, the piston with the sleeve of the MTC in the horizontal and vertical planes were obtained. The diagram of the stress-strain state of the MCP under normalized and non-normalized loading is established. Design schemes for loading the section and the central heating circuit in the horizontal and vertical planes are developed. Conclusions. The results will improve the reliability of the MTC during operation, increase the reliability of the description of changes in the technical condition of the MTC, more reasonably determine the overhaul periods, and clarify the values of the diagnostic parameters, which contributes to the improvement of the system of maintenance and repair, as well as the design of the MTC.
The research of the absorption potential effect of the minerals surface on the cassiterite flotation process
Authors:   JSC Uralmekhanobr, Gazaleeva Galina , Nazarenko Liudmila ,   JSC Uralmekhanobr, Dmitrieva Elena ,   JSC Uralmekhanobr
Published: October 2020

Introduction. The use of flotation for tin additional recovery and in order to increase integrated use of raw materials is one of the main trends in tin ores beneficiation technology development. Research aim is to identify the mechanism of reagents action on the pulp particles surface during the flotation of tin-containing products containing cassiterite. 78 "Izvestiya vysshikh uchebnykh zavedenii. Gornyi zhurnal". No. 3. 2020 ISSN 0536-1028 Methodology. Pulp absorption potential was measured on Dispersion DT-310 electro-acoustic spectrometer from Dispersion Technolodgy Inc., USA. The object of research was the cleaning products of the collective concentrate obtained from beneficiation sludge tailings of Solnechny enrichment plant (the Khabarovsk Territory). The surface of the initial product was sequentially treated with the following reagents: sodium hexametaphosphate, kerosene, liquid glass, aluminum sulfate and the Asparal-F collector reagent with measurements of the absorption potential. At the same time, open flotation experiments were carried out with fractionated removal of the foam product. Results. The research results have shown that the main influence on pulp absorption potential is exerted by a depressor - aluminum sulfate. With its consumption of 800 and 1600 g/t, the value of the absorption potential decreases to the level of minus 1.3–1.4 mV, having a negative extremum. With a further increase in depressor consumption to 2400 g/t, there is a abrupt jump in the absorption potential to positive values. The study of absorption potential value dependence on Asparal-F reagent-collector consumption has shown that an increase in the collector flow rate to 400 g/t causes a abrupt jump and alternation of the potential from + to – (– 0.05 mV) and the intersection of the curve with the zero point allows to determine its optimal flow rate 360 g/t. Flotation of the initial product with fractional removal of foam has shown that it was this jump that led to an increase in the quality of fractions from 0.40 to 1.04% in terms of tin content. Further processing of the obtained flotation tin product according to the gravitational scheme made it possible to obtain conditioned tin concentrate with a tin content of 24.8%. Conclusions. The study of thin intermediate products tin flotation process in the tailings processing flow chart of Solnechny enrichment plant with pulp ζ-potential evaluation revealed some regularities of this indicator influence on the flotation results and the optimal consumption of flotation reagents.
Hydraulic fracture in the nonlinear stress field
Authors: Valerii Mirenkov
Published: October 2020

Introduction. The article considers a variant of a straight finite fracture modeled by a mathematical cut in the elastic plane. Aim. The new model proposed differs from the existing models by the damage zone bounded by the elastic material at the fracture tip up to the moment of the fracture growth. The process of fracturing is essentially nonlinear. Methodology. The model is based on the full-scale tension experiments with a reference sample of rocks enclosing a fracture and having the characteristic stress points, namely, proportionality limit, elasticity limit, plasticity domain and the domain in the vicinity of destructive stresses. Results. The problem with fracture is considered as an experiment to determine deformation with growing pressure in the fracture. The problem has no correct analytical solution. The problem on hydrofracture 20 "Izvestiya vysshikh uchebnykh zavedenii. Gornyi zhurnal". No. 4. 2020 ISSN 0536-1028 assumes the presence of the initial stress field in rock mass, which is essentially used in formulation of boundary conditions. Conclusions. All such problems belong to the class of Cauchy’s problems with an infinitely distant point in the computational domain. This article proposes the correct formulation of the fracture theory problem in the static, kinematic and dynamic framework.
Inductive sounding of layered earth
Authors:   Institute of Geophysics UB RAS, Evgenii Arzamastsev , Pavel Astafiev ,   Institute of Geophysics UB RAS, Sergei Baidikov ,   Institute of Geophysics UB RAS, Aleksei Konoplin ,   Institute of Geophysics UB RAS, Aleksandr Ratushniak ,   Institute of Geophysics UB RAS
Published: October 2020

Research aim. The research results in the development of a technology of continuous multi-frequency induction profiling measuring magnetic field components on long survey routes and detailed elaboration of sections by means of remote induction soundings. Research methodology. Theoretical and experimental studies of magnetic field components change patterns of harmonic vertical magnetic dipole over non-uniform layered earth. Mathematical simulation of harmonic vertical magnetic dipole magnetic field in non-uniform layered earth. Analysis of results. Information value of harmonic vertical magnetic dipole magnetic field components characteristics in low-frequency induction zone has been shown when studying non-uniform geoelectric sections together with the obtained results correspondence to the type of the non-uniform section when carrying out remote inductive sounding. 30 "Izvestiya vysshikh uchebnykh zavedenii. Gornyi zhurnal". No. 4. 2020 ISSN 0536-1028 Scope of results. for extended sections of route research (road and railway, oil and gas pipelines, power transmission lines, etc.) process sequence of vertical magnetic dipole magnetic field characteristics measurement has been determined to determine geoelectric properties of a layered section by means of continuous multi-frequency profiling and determination of homogeneous sections of medium structure with their detailing by discrete analysis by the method of remote inductive sounding.
Information technologies of geomechanical events integrated simulation
Authors:   Ural State Mining University, Maksim Volkov , Boris Polovov ,   Ural State Mining University, Dmitrii Prishchepa ,   Ural State Mining University
Published: October 2020

Introduction. Neither national nor foreign practice can guarantee high-quality assessment of enclosing rock mass state and reliable substantiation of rational geomechanical solutions. It is confirmed by actual accident and breakdown rates including catastrophic force majeure. So, current methods of geomechanical analysis need principal improvement. Research aim is to develop information technologies of integrated deterministic stochastic modeling within the system of assessing and ensuring the quality of geomechanical solutions, which is the set of interconnected estimates and indicators, such as efficient, available, reliable and adequate information on enclosing rock mass properties and state, compliance with the requirements of normative documents, geomechanical risks rates by the factors of breakdown, accident and environmental hazard factors, potential damage from risk aftermath, financial receipts and expenses which include dominant functions of potential damage and monitoring effectiveness. Methodology. Research has been carried out based on the simulation builder, basic software aimed at design, checkout and probation of new integrated deterministically stochastic models of geomechanical events. The models fulfill research, training and demonstration functions, reserve modeling process and output, simulation errors and drawbacks elimination by Monte Carlo method. The main feature of the builder is the availability of interconnected components, determination and simulation. Such complex provides the researcher with important complementary information: deterministic method fulfills safety functions and determines analysis results non-contradiction to the requirements of normative documentation; probabilistic method ensures objective evaluation of geomechanical risks or safe features with the possibility to obtain clear effectiveness by the factors of economic and social security, eliminates or significantly reduces the probability of unnecessary expenses. The universality of the approach to creating information technologies of geomechanical solutions simulation which implement the deterministic simulation complex based on the methods of nonparametric statistics is confirmed by the instances of simulation in multivariate statement. The scope of the investigation includes mine engineering structures of construction, open, integrated technologies of mining enterprises and specific underground development targets in various sectors of national economy. Summary. Information technologies of geomechanical events simulation based on the complex of deterministic and simulation methods and the procedures of nonparametric microstatistics make decisive contribution in the system of assessment and ensuring the quality of geomechanical solutions. The universality of IT development is noted together with their availability for a wide range of users, their simplicity and implementation efficiency
Forecast of potential rockburst hazard during the reconstruction of the Yugo-Zapadnaya mine at the Darasun deposit
Authors:   Institute of Mining UB RAS, Elena Sosnovskaia , Arkadii Avdeev ,   Institute of Mining UB RAS
Published: October 2020

Research aim is to study the geomechanical conditions of the Yugo-Zapadnaya mine at the Darasun gold ore deposit during the reconstruction of mining to forecast the rockburst hazard. Methodology. Laboratory tests of physical and mechanical properties of rocks were carried out. The initial stress-strain state of the rock mass was assessed by natural measurements and by solving the inverse geomechanical problem. The method of finite element analysis determined the technogenic stresses in the structural elements of the geotecnologies. Engineering calculations of critical depths of rockbursts were performed. Results and conclusions. By results of researches it is established, that the natural field of in-situ stresses in the deposit array of rocks is distributed discretely: high-stress, medium-stress and off-load zones are distinguished. The rocks have high strength and elastic properties and are prone to brittle fracture. The actual mining has reached critical depth of rockburst. Air headings and ceiling are in the most hazardous state. To increase the safety of mining, a set of measures has been proposed: unloading roof ceiling and corners with slots, giving the roof a hipped shape, replacing the ceiling with a concrete pillar. It is recommended to conduct operational geomechanical monitoring at the mine.
Estimating air pollution levels by numerical simulation depending on wind flow speed and dust source area
Authors:   Institute of North Industrial Ecology Problems, KSC RAS, Pavel Amosov , Alexander Baklanov ,   World Meteorological Organization, Dmitriy Makarov ,   Institute of North Industrial Ecology Problems, KSC RAS, Vladimir Masloboev ,   Institute of North Industrial Ecology Problems, KSC RAS
Published: October 2020

Research aim is to estimate atmospheric pollution levels in the town of Apatity, by numerical simulation, depending on the discrete arrangement of dust sources at the tailing dump closest to the town and the speed of wind flow. Methodology. For computer 3D modeling, the COMSOL software was used. To calculate the aerodynamic properties the approach of incompressible fluid and standard (k–ε)-model of turbulence were used. The spread of dust pollution has been modeled by numerically solving the convective-diffusion equation of impurity transfer taking into account the deposition rate. Numerical experiments were performed for wind flow speeds between 5 and 23 m/s and a discrete representation of the dust source area between 2 and 10 ha. Results. The spatial distributions of the model's aerodynamic properties and the interval (and total) distributions of dust pollution were obtained. The Starye Apatity area is most exposed to atmospheric pollution. Atmospheric pollution levels were analyzed and generalized to functional dependencies, depending on the values of the model's variable parameters. It is shown that the calculated dependencies between the maximum dust concentration and the dust source area can be described by linear functions, which allows predicting the critical dust source area, at which the level of air pollution reaches the threshold limit value. It is demonstrated that the dependence of the maximum dust concentration on wind flow speed at fixed dust source area values can be approximated by a power-law function. Summary. A generalized analytical formula has been derived that allows predicting maximum dust concentrations in the town of Apatity depending on the discrete locations of dust sources at the tailing dump and the speed of wind flow.
Slags of chromium cast iron production from Alapaevsky plant (composition and geoecology)
Authors:   Institute of Geology and Geochemistry UB RAS, Iurii Erokhin , Anatolii Zakharov ,   Institute of Geology and Geochemistry UB RAS, Liubov Leonova ,   Institute of Geology and Geochemistry UB RAS
Published: October 2020

Relevance. The Ural region has been the metallurgical center of Russia for more than 300 years, and a huge amount of waste slag has accumulated here. The study of the material composition of the slag is an urgent task. Many slags are potential ores that can be further processed. 98 "Izvestiya vysshikh uchebnykh zavedenii. Gornyi zhurnal". No. 5. 2020 ISSN 0536-1028 Research aims to study of the mineral composition of slag from the Alapaevsky metallurgical plant, obtained in the production of chromium cast iron. Research methodology. The chemical composition of minerals was established using a JSM-6390LV Scanning Electron Microscope from Jeol with the INCA Energy 450 X-Max 80 energy-dispersive attachment from Oxford Instruments (IGG UB RAS, Ekaterinburg). For the analysis polished petrographic thin sections cut from pieces of slag were used. Originality. Slags material composition was studied from the point of view of classical mineralogy and with the use of modern mandatory nomenclature of the International Mineralogical Association. Findings. The mineralogy of the Alapaevsky plant chromium cast iron production slags has been studied for the first time. It has been established that they are composed of a periclase-larnite aggregate with a significant content of gehlenite, magnesiochromite and the Ti-analogue of schulamitite, as well as the constant presence of wustite, spinel, sulfides and cast iron. These slags are the waste products of low-alloy heat-resistant chromium cast iron and pose a geo-ecological threat to the environment. Practical relevance. These slags can be recycled, as they contain easily distinguishable magnetic chromium cast iron and wustite. Almost half of the rock consists of periclase, which is a refractory raw material, and spinel can be used as an abrasive material
Rationale for main fans service life in the conditions of changing load
Authors:   Ural State Mining University, Ekaterinburg, Valerii Kopachev
Published: October 2020

Research aim is to study basic regularities in functional condition change of main fans included in the confi guration of main mine ventilation installations depending on the technological service conditions. The research also aims to determine the standard service life of main fans with the account of the diff erential analysis of the destructive factors, structural features, intensity and modes of operation of ventilation plants. 108 "Izvestiya vysshikh uchebnykh zavedenii. Gornyi zhurnal". No. 6. 2020 ISSN 0536-1028 Research methodology. Based on the analysis of main fan installations structure and differential analysis of technological factors affecting the functional efficiency of main fans, a mathematical model has been proposed which determines the standard and residual life of the main fan with the account of the changing load. Results and analysis. As a result of studying the impact of destructive factors on the main functional parts of the main fan, an equation has been proposed, which takes into account the physical properties of the material the fan elements are made of together with the quantitative effect of the external physical factors on the machine’s operation. Research results show that the resource of the main fans should be determined based on the useful life of the machine’s major component, i.e. mainshaft, with the account of the machine’s operation mode. Conclusions and scope of results. Circuit designs of mine ventilation plants predetermine the main fans service life. The service life should be established at the stage of the detail design with the account of the differential analysis of the destructive factors, structural features, intensity and operation modes of ventilation plants. The proposed methodology for main mine fans residual life determination is applied in expert organizations and Guidances on the determination of residual life of main mine fans which operate under the excess of the standard service life. The methodology may also be applied by project organizations to determine the design service life for the constructed main ventilation installations.
The 100th anniversary of the Ural Higher School of Mine Surveying
Authors:   Kuban State Technological University, Viktor Gordeev
Published: October 2020

The article contains the historical note on the establishment and development of the Ural Higher School of Mine Surveying, the department of Mine Surveying of the Ural State Mining University, within 100 years of existence. The founder and the first chairperson was P. K. Sobolevskii. D. N. Ogloblin, G. I. Vilesov, P. A. Ryzhov, A. A. Igoshin, P. P. Bastan, G. L. Fisenko, I. M. Petukhov and many other renowned scientists and production workers were the graduating students of the department. It is the specialized department training surveyors in the Urals and Western Siberia.
The criterion of block media strength and geomechanical back-calculation
Authors:   Ural State Mining University, Andrei Zhabko
Published: October 2020

Relevance and problematics. The mechanism of block medium and jointed rock mass deformation and breaking differs notably from continuum mechanics ideas, making up the crucial fundamental problem of geomechanics and distinguishing it from other engineering sciences connected with the mechanics ISSN 0536-1028 «Известия вузов. Горный журнал», № 6, 2020 47 of deformable solids. However, due to poor understanding of block media breaking mechanism, rock masses strength is overwhelmingly estimated by means of empirical dependences obtained by simulation in laboratory conditions. It is apparent that this approach does not solve the crucial fundamental problem and the accuracy of predicting mechanical characteristics of jointed rock masses may reach 100%. Research methodology. Based on the earlier theoretical research by the methods of variational, integral, and differential calculus, a new mechanism of block mass breaking at a point was substantiated. It implies translation and rotational character of blocks displacement in a rock mass in the process of its deformation making it possible to substantiate the criterion of jointed rock masses breaking. Research results, analysis and recommendations for use. The research was the first to obtain the block medium strength criterion. It has been shown that block mass strength is made up of the strength along the slip joint and block rotation resistance. Besides, within some range of loads, the ultimate strength of the rock mass is proportional to the tensile strength of a structure block. The work also proposes a range of analytical dependences obtained based on the solid mechanics making which make it possible to back calculate the rock mass strength based on the curvature of the shear rupture surface and assess the full tensor of the plain field of strain by the base axes orientation.
Economic efficiency of preconcentration with X-ray fluorescence separation
Authors:   Ural State Mining University, Evgenii Tsypin , Tatiana Efremova ,   Scientific-Research and Design Institute JSC Uralmekhanobr, Tatiana Ovchinnikova ,   Ural State Mining University
Published: October 2020

Introduction. A promising direction in mineral processing development is the combination of preconcentration and deep processing. For that purpose, X-ray fluorescence separation (XFS) is highly effectively used. A feature of the technology is the availability of the procedures of crushing and screening of the initial rock into machine and unsortable classes, and separation in machine classes. The efficiency of preconcentration complex depends on the quality of granulometric composition forming procedures. Methodology. X-ray radiometric washability of polymetallic ore samples has been assessed, schemes and equipment for preconcentration with the use of X-ray fluorescence separation of the rock mass with various granulometric composition have been selected, and technical and economic assessment has been made. Results. Economic indicators of X-ray fluorescence separation application for preconccentration have been determined for polymetallic ore of various granulometric composition. The possibilities for significant improvement of the economic effect by means of forming the granulometric composition of the processed rock mass have been revealed. Summary. X-ray fluorescence separation in polymetallic ore preconcentration is highly effective. Optimization of blasted rock mass granulometric composition by means of specific organization of drilling and blasting operations and selecting specific modes of crushing and screening results in the growth of the economic effect from XFS by 2.1–2.7 times.
Semen Analysis and Morphological Study of Two Subsequent Generations of Dietary Protein Deficient Sprague Dawley Rats
Authors: Abey Nosarieme Omoregie , Ebuehi Osaretin Albert Taiwo
Published: October 2020

Adequate supply of dietary protein in regular diet is an important element of a proper nutritional status as it functions in the regulation of metabolic profiles signaling the reproductive axis. Reports have highlighted the association of the amount of protein in the diet to the functioning of hypothalamic-pituitary-testis axis, however its intragenerational effects are yet to be adequately explored. The study aims to analyze the effect of protein deficient diet on parameters associated with male infertility from one generation to another. Female rats in four (4) groups (n=10) were fed different ration of protein in their diet (PD) as formulated: 21%PD, 10%PD, 5%PD and control diet (rat chow), through gestation and lactation to first and second generations, while the male offspring sustained on the maternal diet after weaning were used for analysis.  Sperm morphology and motility were evaluated using a light microscope and a computer-assisted semen analysis. The percentage of motile spermatozoa, morphological characteristics and histology in the deficient groups (5%, 10%PD) appeared normal as compared to control in the first generation, showing an adaptive response while second generation was presented with significantly altered fertility parameters of the male offspring. It is suggested that in a deficiency status especially at the critical phase of development, certain deleterious effects which may be adaptive or phenotypic can serve to reduce the fertility efficiency in the male offspring at both F1 and F2- generation.
Relaxation of bosons in one dimension and the onset of dimensional crossover
Authors: Li Chen , Zhou Tianwei , Mazets Igor , Stimming Hans-Peter , Møller Frederik Skovbo , Zhu Zijie , Zhai Yueyang , Xiong Wei , Zhou Xiaoji , Chen Xuzong , Schmiedmayer Jörg
Published: October 2020

We study ultra-cold bosons out of equilibrium in a one-dimensional (1D) setting and probe the breaking of integrability and the resulting relaxation at the onset of the crossover from one to three dimensions.
In a quantum Newton's cradle type experiment, we excite the atoms to oscillate and collide in an array of 1D tubes and observe the evolution for up to 4.8 seconds (400 oscillations) with minimal heating and loss.
By investigating the dynamics of the longitudinal momentum distribution function and the transverse excitation, we observe and quantify a two-stage relaxation process.
In the initial stage single-body dephasing reduces the 1D densities, thus rapidly drives the 1D gas out of the quantum degenerate regime. The momentum distribution function asymptotically approaches the distribution of quasimomenta (rapidities), which are conserved in an integrable system.
In the subsequent long time evolution, the 1D gas slowly relaxes towards thermal equilibrium through the collisions with transversely excited atoms.
Moreover, we tune the dynamics in the dimensional crossover by initializing the evolution with different imprinted longitudinal momenta (energies).
The dynamical evolution towards the relaxed state is quantitatively described by a semiclassical molecular dynamics simulation.
EFEITO DA SUPLEMENTAÇÃO COM ÓLEO DE PEIXE NO MODELO EXPERIMENTAL DE SEPSE
Authors: Campos Renata , Bortoti Andressa Antunes , Steclan Chelin Auswaldt , Pawlowytsch Pollyana Weber da Maia , Valério Miriam Cristina José , Paluch Cinthia Helena , Fernandes Luiz Cláudio
Published: October 2020

Introdução: A sepse é uma síndrome de grande prevalência, que causa altas morbidade e mortalidade. Terapêuticas adjuntas ao tratamento clínico convencional devem ser estudadas a fim de minimizar os efeitos da sepse. Objetivo: Investigar o efeito da suplementação com óleo de peixe (OP), rico em ômega-3, sobre as funções renal e pulmonar, a mortalidade e o estresse oxidativo de ratos com sepse. Metodologia: A sepse foi induzida por punção e ligadura cecal (CLP). O ômega (1 g/kg/dia, via oral) foi administrado, sete dias antes da CLP. Foram estudados os grupos Sham (CLP sem OP, n=10) e CLP+OP (suplementado com OP, n=10). Foram analisados o estresse oxidativo, e a histologia pulmonar e renal, quanto à sua estrutura e presença de polimorfinucleares (PMN), índice de edema pulmonar, função renal e sobrevida em 72 horas. Resultados: O estresse oxidativo não foi diferente para o grupo CLP +OP (p=0,06). A histologia, quanto à estrutura, evidenciou que o grupo suplementado com OP teve menor lesão estrutural, tanto no tecido pulmonar quanto no renal, entretanto, a contagem de polimorfinucleares (PMN) não foi diferente entre os grupos, para ambos os sistemas. O índice de edema pulmonar, embora menor no grupo CLP+OP, não foi significativamente diferente do encontrado no grupo Sham (p=0,59). Não houve alterações quanto à melhora da sobrevivência causada pela suplementação com OP. A função renal, estudada pela ureia e pela creatinina, não foi diferente entre os grupos. Conclusão: A suplementação com óleo de peixe (OP), neste estudo, não melhorou as condições renais, pulmonares e de mortalidade de ratos com sepse.
EFEITO IN VITRO DO EXTRATO DE CAMELLIA SINENSIS SOBRE O DNA DE LEUCÓCITOS HUMANOS
Authors: Drews Daniele Scherer , Da Cruz Ivana Beatrice Manica , Feyh dos Santos Montagner Greice Franciele
Published: October 2020

Bebidas à base de Camellia sinensis tem sido utilizadas por muitos séculos na medicina tradicional, sendo a infusão preparada com as suas folhas. Um dos produtos à base de C. sinensis amplamente consumido é o chá verde, sendo que seus benefícios vem sendo associados a sua composição química. Por este motivo o objetivo deste trabalho foi avaliar a possível atividade genotóxica do extrato de chá verde através da avaliação de danos no DNA pelo Teste Cometa. Desta forma, foi conduzido um ensaio in vitro a partir de leucócitos isolados de sangue periférico de indivíduos saudáveis. Os leucócitos isolados foram tratados com diferentes concentrações de extrato de C. sinensis, posteriormente sendo avaliado o dano no DNA pelo Teste Cometa. Os resultados encontrados neste trabalho indicaram que nas concentrações 3μg/mL, 10μg/mL, 30μg/mL, 100μg/mL e 300μg/mL o extrato de C. sinensis comportou-se igual ao controle não apresentando diferença significativa no índice de danos do DNA, o que indica que nas concentrações utilizadas o extrato não apresentou efeito genotóxico. O uso do chá verde na dieta pode ter muitos benefícios para o organismo, principalmente pelos seus compostos bioativos e, por este motivo, fazem-se necessários estudos para avaliar sua toxicidade, para melhor avaliar a segurança em seu uso.
EFFECTS OF TYPE 2 DIABETES MELLITUS INDUCTION AND OF MODERATE PHYSICAL EXERCISE ON THE HEPATIC METABOLISM AND OXIDATIVE STRESS IN WISTAR RATS
Authors: Oliveira Denise Silva de , Santos Júlia Matzenbacher dos , Prado Kayorrany Gomes Galvão do , Amaral Andreia Vitor Couto , Benite-Ribeiro Sandra Aparecida
Published: October 2020

AIMS: The aim of the study was to verify if the induction of Type 2 Diabetes Mellitus (T2DM) by the association of streptozotocin and high fat diet causes hepatic alterations and if physical exercise can improve these alterations.  METHODS: Forty-six Wistar rats were divided into two groups. One group received a diet containing 60% of fat for 9 weeks and on the 14th day they were injected with a single dose of streptozotocin (25mg/kg). The other group, named control group, received a standard diet and a single dose of citrate buffer was given. Animals were them divided into two subgroups: one sedentary (S) and the other submitted to physical exercise (PE), totalizing four groups: C-S; C-PE; HF-S; HF-PE. After euthanasia blood and liver were collected. Plasma and hepatic concentrations of triacylglycerol and very low density lipoprotein; enzyme alanine transaminase, aspartate transaminase and arginase; urea, lactate and 8-isoprostane (an oxidative stress marker) were dosed. RESULTS: Capillary glucose was significantly higher in HF-S and HF-PE group animals compared to C-S and C-PE groups. There were no significant differences in alanine transaminase, arginase, oxidative stress and lactate concentration among the groups. Plasma urea concentration and hepatic aspartate transaminase concentration was lower in HF-S and HF-PE than in C-PE. Concerning liver triacylglycerol and very low density lipoproteins, both were higher in the HF-PE group when compared to the C-S. CONCLUSIONS: We conclude that diet was decisive for the aforementioned parameters alterations and that physical exercise protocol was not efficient to improve analyzed parameters.
Nâbî’nin Hayriyye Adlı Eserinin Eğitim Değeri
Authors: AÇIK Nilgün
Published: October 2020

Kişilik
gelişimi, bireyin hayatı boyunca karşılaştığı sorunlara uygun çözümler ürete­bilmesi, duygularını doğru biçimde ifade
edebilmesi, sosyal çevreye uyum sağlaması sürecini kapsar. Bu süreçte edebî ürünler
aracılığıyla, çocukların
eğitimi, olgunlaşması, sosyalleşmesi ve diğer ruhî ihtiyaçlarının karşılanması
konusu önem arz eder. Bu çerçevede
edebî ürünler aracılığıyla çocukların
eğitilmesi konusuna önem verilmelidir.

Çocuklar
için yazılan metinler veya kitaplar, değişik hayat modellerini sanatçı bakış açısı
ile sunar. Bunlar, çocuklara değişik görüşlerin, çatışmaların, problem çözme
metotlarının, farklı kültürlerde farklı şekillerde olabileceğini öğretir. Çocuklara
kitap seçerken kültürel zenginliklerin, inanç, ahlâk ve geleneklerin kazandırılmasına
önem verilmelidir. Seçilen metin veya kitapların; çocukların insanî duygu ve
hasletlerini geliştirici, şekillendirici olmasına, metinler yoluyla verilen mesajların,
çocuklarda görülmek istenilen davranışlar ve kişilikle örtüşmesine dikkat
edilmelidir.

Bu
çerçevede, yol göstericiliği bakımından eğitim değeri araştırılması gereken Nâbî’nin
Hayriyye adlı eseri, güzel ahlâk sahibi olmanın önemini anlatır. Nâbî bu
eserinde, oğlu aracılığıyla bütün çocuklara hayat tecrübelerini aktarmak ve
onlara öğütlerde bulunmak istemiştir. Nâbî, Türk edebiyatında kendisinden sonra
gelen pek çok edip ve şairi etkilemiş, yol göstericiliği bakımından dikkati
çeken Hayriyye mesnevisi ile pek çok araştırmaya kaynaklık etmiştir.
Okul Öncesi Eğitimde Aile Katılımı: Anne ve Baba Görüşleri
Authors: ORÇAN KAÇAN Maide , DÖNMEZ Zeynep , KİMZAN İlayda
Published: October 2020

Bu araştırma, anne ve babaların aile katılımına ilişkin görüşlerini incelemek amacıyla yapılmıştır. Araştırmanın evrenini normal gelişim gösteren ve okul öncesi eğitim kurumuna devam eden 4-5 yaş çocukların anne ve babaları oluşturmuştur. Araştırmanın çalışma grubuna, evren içinden Milli Eğitim Bakanlığı'na bağlı bağımsız anaokulları ve anasınıfları arasından tesadüfî olarak, araştırmaya katılmaya gönüllü olan her sınıftan iki anne ve iki baba olmak üzere toplam 31 anne ve 33 baba dahil edilmiştir. Araştırmada genel tarama model kullanılmış olup, veri toplama aracı olarak anne babalara ilişkin genel bilgileri toplamak amacıyla Genel Bilgi Formu ve anne babaların aile katılımına ilişkin görüşlerini incelemek amacıyla Perry, Fantuzzo ve Munis (1997,2002) tarafından geliştirilen ve Ahmetoğlu, Acar, Sezer ve Akşin Yavuz (2018) tarafından Türk kültürüne uyarlanan Aile Katılım Ölçeği (AKÖ) kullanılmıştır. Araştırmanın amacı doğrultusunda elde edilen verilerin analizinde betimsel analizler ile anne ve babaların ailekatılımı alt ölçek ve toplam ölçek puanlarını karşılaştırmak için Mann-Whitney U testi analizlerine yer verilmiştir. Araştırma sonucunda, anne ve babaların okul ve ev-okul iş birliği temelli aile katılımı puanları ile toplam ölçek puanları arasında anneler lehine anlamlı fark olduğu belirlenmiştir.
Novel Nano Carriers for the Treatment of Progressive Auto Immune Disease Rheumatoid Arthritis
Authors: Mishra Ritu , Gupta Swati
Published: October 2020

Rheumatoid arthritis (RA) is the most commonly occurring, progressive, autoimmune disease, affecting
1% of the population and the ratio of affected women is three times as compared to men in most developing
countries. Clinical manifestations of RA are the presence of anti-citrullinated protein antibody (ACPA) and
rheumatoid factor (RF) in blood, tendered joints and soreness of the muscles. Some other factors which may
lead to chronic inflammation are genetic and environmental factors as well as adaptive immune response. Several
conventional drugs are available for the treatment of RA but have their own drawbacks which can be overcome
by the use of novel drug delivery systems. The objective of the present review is to focus on the molecular
pathogenesis of the disease and its current conventional treatment with special reference to the role of novel
drug delivery systems encapsulating anti-rheumatic drugs and herbal drugs in passive and receptor-mediated active
targeting against RA. On reviewing the conventional and current therapeutics against RA, we conclude that
although the current therapy for the treatment of RA is capable enough, yet more advances in the field of targeted
drug delivery will sanguinely result in effective and appropriate treatment of this autoimmune disease.
Nanomedicine against Alzheimer’s and Parkinson’s Disease
Authors: Tandon Ankit , Singh Sangh J. , Chaturvedi Rajnish K.
Published: October 2020

Alzheimer’s and Parkinson’s are the two most rampant neurodegenerative disorders worldwide. Existing
treatments have a limited effect on the pathophysiology but are unable to fully arrest the progression of
the disease. This is due to the inability of these therapeutic molecules to efficiently cross the blood-brain barrier.
We discuss how nanotechnology has enabled researchers to develop novel and efficient nano-therapeutics
against these diseases. The development of nanotized drug delivery systems has permitted an efficient, site-targeted,
and controlled release of drugs in the brain, thereby presenting a revolutionary therapeutic approach.
Nanoparticles are also being thoroughly studied and exploited for their role in the efficient and precise diagnosis
of neurodegenerative conditions. We summarize the role of different nano-carriers and RNAi-conjugated
nanoparticle-based therapeutics for their efficacy in pre-clinical studies. We also discuss the challenges underlying
the use of nanomedicine with a focus on their route of administration, concentration, metabolism, and any
toxic effects for successful therapeutics in these diseases.
Death Due to COVID-19 in an Infant with Combined Immunodeficiencies
Authors: Ahanchian Hamid , Moazzen Nasrin , Saeidinia Amin , Joghatayi Seyed H. , Khoshkhui Maryam , Aelami Mohammad H. , Haghi Nasrin S. M. , Rezaei Nima
Published: October 2020

Background:

Severe Acute Respiratory Syndrome Coronavirus 2 has affected millions
of people, and especially in adult patients with underlying diseases lead to death. Meanwhile pediatric
patients with inherited defects of T cell should be prone to viral diseases.

Case Presentation:

Herein, we report an infant with severe combined immunodeficiencies, who
were affected and died because of COVID-19.

Conclusion:

Considering the importance of finding how immune system can affect the viral infection,
presentation of COVID-19 in immune deficient patients can be valuable.
The Role of Advanced Technologies Supplemented with Traditional Methods in Pharmacovigilance Sciences
Authors: Satwika Mandali V. , Sushma Dudala S. , Jaiswal Varun , Asha Syed , Pal Tarun
Published: October 2020

Background:

The immediate automatic systemic monitoring and reporting of adverse drug reactions, improving the efficacy is the utmost need of the medical informatics community. The venturing of advanced digital technologies into the health sector has opened new avenues for rapid monitoring. In recent years, data shared through social media, mobile apps, and other social websites has increased manifolds requiring data mining techniques.

Objective:

The objective of this report is to highlight the role of advanced technologies together with the traditional methods to proactively aid in the early detection of adverse drug reactions concerned with drug safety and pharmacovigilance.

Methods:

A thorough search was conducted on papers and patents regarding pharmacovigilance. All articles with respect to the relevant subject were explored and mined from public repositories such as Pubmed, Google Scholar, Springer, ScienceDirect (Elsevier), Web of Science, etc.

Results:

The European Union’s Innovative Medicines Initiative WEB-RADR project has emphasized the development of mobile applications and social media data for reporting adverse effects. Only relevant data has to be captured through the data mining algorithms (DMAs) as it plays an important role in timely prediction of risk with high accuracy using two popular approaches; the frequentist and Bayesian approach. Pharmacovigilance at the pre-marketing stage is useful for the prediction of adverse drug reactions in the early developmental stage of a drug. Later, post-marketing safety reports and clinical data reports are important to be monitored through electronic health records, prescription-event monitoring, spontaneous reporting databases, etc.

Conclusion:

The advanced technologies supplemented with traditional technologies are the need of the hour for evaluating a product’s risk profile and reducing risk in population especially with comorbid conditions and on concomitant medications.
Bifocal Disruption of the Patellar Tendon with Avulsion of the Tibial Tuberosity: A Case Report
Authors: Sekiguchi Takuya , Hagiwara Yoshihiro , Honda Masahito , Itoi Eiji
Published: October 2020

Introduction:

Bifocal disruption of the knee extensor system is rare. Coincident bifocal proximal and distal disruptions of the patellar tendon are extremely rare in adults.

Case Report:

A 38-year-old man presented to our clinic with severe right knee pain after falling down the stairs and abruptly bending the right knee. Plain radiographs of this knee showed tibial avulsion and a high riding patella, suggesting underlying Osgood-Schlatter disease, which was also present to a milder degree in the left knee. Magnetic resonance imaging confirmed an avulsion of the tibial tuberosity and showed concomitant avulsion of the patellar tendon without bone marrow edema. Computed tomography showed that the fragment of the tibial tuberosity had a dull-edged margin, and cortical bones were partially exposed. During surgery, the patellar tendon was divided into superficial and deep layers. The superficial layer was peeled from an attachment at the patella, while the deep layer was from the tibia and contained the fragment of the tibial tuberosity. The detached side of the fragment and tibia were coated with dense, fibrous tissue. Surgical repair was performed, with excellent outcomes. Radiographic and intraoperative findings suggested Osgood-Schlatter disease, which might cause avulsion of the tibial tuberosity.

Conclusion:

This is the first case of the bifocal proximal and distal rupture of the patellar tendon with the avulsion of the tibial tuberosity. Bifocal disruption of the patellar tendon should be considered in patients presenting with avulsion of the tibial tuberosity and suspected Osgood-Schlatter disease.
Kerjasama Pengembangan Medium Battle Tank Harimau Sebagai Perwujudan Ketahanan Alutsista Tentara Nasional Indonesia
Authors: Triantama Febry
Published: October 2020

Sistem internasional yang anarki memaksa negara-negara di dunia untuk memastikan kelangsungan hidupnya sendiri. Negara-negara berlomba-lomba untuk meningkatkan kapasitas power mereka, salah satunya diimplementasikan melalui kemandirian pertahanan. Indonesia sebagai negara yang telah memiliki pengalaman buruk akibat dari ketergantungan terhadap alutsista yang diproduksi negara lain serta berupaya mewujudkan ketahanan alutsista tengah gencar melakukan pengembangan industri pertahanannya. Salah satunya adalah pengembangan medium battle tank Harimau bersama dengan Turki.Artikel ini akan membedah alasan Indonesia melakukan pengembangan medium battle tank Harimau dengan Turki menggunakan konsep techno-nationalist impulse dan melalui metode deskriptif analitis.Artikel ini menyatakan bahwasanya keputusan Indonesia melakukan pengembangan medium battle tank merupakan strategi perwujudan ketahanan alutsista dan didasarkan pada pursuit of power, pursuit of wealth serta pursuit of prestige.
A Multicultural Approach in Learning Review of Indonesian Fine Arts
Authors: - Iswahyudi
Published: October 2020

Multicultural awareness in Indonesia has been widely discussed since the Dutch colonial era. According to Furnivall, that the plural society in the Dutch East Indies consisted of two unique characteristics, which were horizontally marked by social unions based on differences in ethnicity, religion and tradition. Then vertically, the structure of the society is marked by sharp differences between the upper and lower layers. In this case, there are two key words, namely between the peaks of regional culture and foreign culture, in this case if there is a fading of the sense of unity because they think that one ethnic group feels that its culture is superior to another, there will be inequality which endangers the multicultural nature. Based on this, in order to avoid learning the history of Indonesian fine art that is not based on multiculturalism, in this case it has long been initiated with a more democratic substance as in the Archipelago Art Review course since the 1980s on the grounds that there are many artistic remains outside the islands of Java, Sumatra and Bali which has been built since the end of prehistoric times.
Max Weber
Authors: Lane Jan-Erik
Published: October 2020

Why would you deny that Max Weber is the foremost social scientist ever? His range and scope is larger and deeper than that of Marx and Durkheim or Schumpeter. He had clear microfoundation and rejected socialist utopia.