bluuebunny/crossref_metadata_2025 huggingface dataset:
The Nucleolar Protein Nucleophosmin Is Physiologically Secreted by Endothelial Cells in Response to Stress Exerting Proangiogenic Activity Both In Vitro and In Vivo
Authors: Di Carlo Anna , Beji Sara , Palmerio Silvia , Picozza Mario , D’Agostino Marco , Petrozza Vincenzo , Melchionna Roberta , Germani Antonia , Magenta Alessandra , De Falco Elena , Avitabile Daniele
Published: April 2021

Nucleophosmin (NPM), a nucleolar multifunctional phosphoprotein, acts as a stress sensor in different cell types. NPM can be actively secreted by inflammatory cells, however its biology on endothelium remains unexplored. In this study, we show for the first time that NPM is secreted by human vein endothelial cells (HUVEC) in the early response to serum deprivation and that NPM acts as a pro-inflammatory and angiogenic molecule both in vitro and in vivo. Accordingly, 24 h of serum starvation condition induced NPM relocalization from the nucleus to cytoplasm. Interestingly, NPM was increasingly excreted in HUVEC-derived conditioned media in a time dependent fashion upon stress conditions up to 24 h. The secretion of NPM was unrelated to cell necrosis within 24 h. The treatment with exogenous and recombinant NPM (rNPM) enhanced migration as well as the Intercellular Adhesion Molecule 1 (ICAM-1) but not Vascular cell adhesion protein 1 (VCAM-1) expression and it did not affect cell proliferation. Notably, in vitro tube formation by Matrigel assay was significantly increased in HUVEC treated with rNPM compared to controls. This result was confirmed by the in vivo injection of Matrigel plug assay upon stimulation with rNPM, displaying significant enhanced number of functional capillaries in the plugs. The stimulation with rNPM in HUVEC was also associated to the increased expression of master genes regulating angiogenesis and migration, including Vascular Endothelial Growth Factor-A (VEGF-A), Hepatocyte Growth Factor (HGF), Stromal derived factor-1 (SDF-1), Fibroblast growth factor-2 (FGF-2), Platelet Derived Growth Factor-B (PDGF-B), and Matrix metallopeptidase 9 (MMP9). Our study demonstrates for the first time that NPM is physiologically secreted by somatic cells under stress condition and in the absence of cell necrosis. The analysis of the biological effects induced by NPM mainly related to a pro-angiogenic and inflammatory activity might suggest an important autocrine/paracrine role for NPM in the regulation of both phenomena.
Optimisation of Recombinant Myrosinase Production in Pichia pastoris
Authors: Rosenbergová Zuzana , Kántorová Kristína , Šimkovič Martin , Breier Albert , Rebroš Martin
Published: April 2021

Myrosinase is a plant defence enzyme catalysing the hydrolysis of glucosinolates, a group of plant secondary metabolites, to a range of volatile compounds. One of the products, isothiocyanates, proved to have neuroprotective and chemo-preventive properties, making myrosinase a pharmaceutically interesting enzyme. In this work, extracellular expression of TGG1 myrosinase from Arabidopsis thaliana in the Pichia pastoris KM71H (MutS) strain was upscaled to a 3 L laboratory fermenter for the first time. Fermentation conditions (temperature and pH) were optimised, which resulted in a threefold increase in myrosinase productivity compared to unoptimised fermentation conditions. Dry cell weight increased 1.5-fold, reaching 100.5 g/L without additional glycerol feeding. Overall, a specific productivity of 4.1 U/Lmedium/h was achieved, which was 102.5-fold higher compared to flask cultivations.
Alpha-1 Antitrypsin-Induced Endoplasmic Reticulum Stress Promotes Invasion by Extravillous Trophoblasts
Authors: Yoshida Kanoko , Kusama Kazuya , Fukushima Yuta , Ohmaru-Nakanishi Takako , Kato Kiyoko , Tamura Kazuhiro
Published: April 2021

Alpha-1 antitrypsin (A1AT) is a glycoprotein that has been shown to protect tissues from proteolytic damage under various inflammatory conditions. Several studies show that A1AT may be associated with pre-eclampsia. However, the role of A1AT expression in placental physiology is not fully understood. In the present study, we aim to characterize the expression and function of placental A1AT. A1AT knockdown is found to reduce the expression of the serine protease HTRA1 in a trophoblast cell line. In addition, A1AT overexpression (A1AT-OE) increases the expression of HTRA1, IL6, CXCL8, and several markers of endoplasmic reticulum (ER) stress. Treatment with tunicamycin or thapsigargin, which induces ER stress, increases HTRA1 expression. Furthermore, immunohistochemistry reveals that HTRA1 is expressed in trophoblasts and the endometrial decidual cells of human placentas. An invasion assay shows that A1AT and HTRA1 stimulate cell invasion, but treatment with the ER stress inhibitors reduces the expression of HTRA1 and ER stress markers and prevents cell invasion in A1AT-OE trophoblasts. These results suggest that endogenous A1AT regulates inflammatory cytokine expression and HTRA1-induced trophoblast invasion via the induction of ER stress. It is concluded that an imbalance in the functional link between A1AT and ER stress at the maternal–fetal interface might cause abnormal placental development.
N-Terminal Acetyltransferase Naa40p Whereabouts Put into N-Terminal Proteoform Perspective
Authors: Jonckheere Veronique , Van Damme Petra
Published: April 2021

The evolutionary conserved N-alpha acetyltransferase Naa40p is among the most selective N-terminal acetyltransferases (NATs) identified to date. Here we identified a conserved N-terminally truncated Naa40p proteoform named Naa40p25 or short Naa40p (Naa40S). Intriguingly, although upon ectopic expression in yeast, both Naa40p proteoforms were capable of restoring N-terminal acetylation of the characterized yeast histone H2A Naa40p substrate, the Naa40p histone H4 substrate remained N-terminally free in human haploid cells specifically deleted for canonical Naa40p27 or 237 amino acid long Naa40p (Naa40L), but expressing Naa40S. Interestingly, human Naa40L and Naa40S displayed differential expression and subcellular localization patterns by exhibiting a principal nuclear and cytoplasmic localization, respectively. Furthermore, Naa40L was shown to be N-terminally myristoylated and to interact with N-myristoyltransferase 1 (NMT1), implicating NMT1 in steering Naa40L nuclear import. Differential interactomics data obtained by biotin-dependent proximity labeling (BioID) further hints to context-dependent roles of Naa40p proteoforms. More specifically, with Naa40S representing the main co-translationally acting actor, the interactome of Naa40L was enriched for nucleolar proteins implicated in ribosome biogenesis and the assembly of ribonucleoprotein particles, overall indicating a proteoform-specific segregation of previously reported Naa40p activities. Finally, the yeast histone variant H2A.Z and the transcriptionally regulatory protein Lge1 were identified as novel Naa40p substrates, expanding the restricted substrate repertoire of Naa40p with two additional members and further confirming Lge1 as being the first redundant yNatA and yNatD substrate identified to date.
Does the Modification of the Apical Geometry of a Dental Implant Affect Its Primary Stability? A Comparative Ex Vivo Study
Authors: Staedt Henning , Heimes Diana , Lehmann Karl M. , Ottl Peter , Bjelopavlovic Monika , Wagner Wilfried , Al-Nawas Bilal , Kämmerer Peer W.
Published: April 2021

(1) Background: Primary stability—one fundamental criterion for the success of dental implants—is influenced by implant geometry even if the effect of apical shape modifications on implant primary stability has not yet been examined. Therefore, the aim of the ex vivo study was to compare primary stability of implants differing in apically located screw threads (J-line) or a flat tip (K-line) only. (2) Methods: 28 implants of each group of the same diameter (4.3 mm) were randomly inserted into porcine bone blocks. The first group (9, 11 and 13 mm) was inserted into “hard”, the second (11 mm) into “soft” bone, here using a normal and an undersized drilling protocol. Insertion torque (Ncm), Periotest® value, resonance frequency (implant stability coefficient, ISQ) and push-out force (N) were measured. (3) Results: In “hard” bone, primary stability increased with increasing length in both groups but it was significantly higher in J-line (p < 0.03). An undersized preparation of the implant bed in “soft” bone resulted in a significant increase in primary stability in both groups. Here, J-line also showed a significantly increased primary stability when compared to equally prepared K-line (insertion torque: 37 Ncm vs. 26 Ncm; Periotest®: −6.5 vs. −4.3; push-out force: 365 N vs. 329 N; p < 0.05 each). (4) Conclusions: Primary stability is significantly higher with increasing implant length and apically located screw threads as well as with undersized drilling protocols. When preparing the implant site and subsequently selecting the implant system, modifying factors such as implant geometry (also at the tip) should be taken into account.
Development of Antioxidant Protein Extracts from Gilthead Sea Bream (Sparus aurata) Side Streams Assisted by Pressurized Liquid Extraction (PLE)
Authors: de la Fuente Beatriz , Pallarés Noelia , Berrada Houda , Barba Francisco J.
Published: April 2021

The pressurized liquid extraction (PLE) technique was used, for the first time, to obtain protein extracts with antioxidant activity from side streams (muscle, heads, viscera, skin, and tailfins) of gilthead sea bream (Sparus aurata) in order to give added value to these underutilized matrices. Extraction conditions previously optimized for sea bass (Dicentrarchus labrax) side streams were applied. Protein recovery percentages were 22% (muscle), 33% (heads), 78% (viscera), 24% (skin), and 26% (tailfins), which represented an increase of 1.2–4.5-fold compared to control samples (extraction by stirring). The SDS-PAGE profiles revealed that PLE-assisted extraction influenced protein molecular weight distribution of the obtained extracts. PLE conditions also allowed increasing the antioxidant capacity measured by both Trolox equivalent antioxidant capacity (TEAC; 1.3–2.4 fold) and oxygen radical absorbance capacity (ORAC; 1.9–6.4) assays for all fish extracts. Inductively coupled plasma mass spectrometry (ICP-MS) and high-performance liquid chromatography coupled with electrospray ionization quadrupole time-of-flight mass spectrometry (LC-ESI-qTOF-MS) were used to investigate the presence of toxic metals and mycotoxins in sea bream side streams. The levels of As, Hg, Cd, and Pb were below those established by authorities for fish muscle for human consumption (except for Cd in viscera samples). Through a nontargeted screening approach, no mycotoxins or related metabolites were detected for all sea bream side streams. This study contributes to the research on the valorization of fish processing side streams using environmentally friendly technology.
Robust Computationally-Efficient Wireless Emitter Classification Using Autoencoders and Convolutional Neural Networks
Authors: Almazrouei Ebtesam , Gianini Gabriele , Almoosa Nawaf , Damiani Ernesto
Published: April 2021

This paper proposes a novel Deep Learning (DL)-based approach for classifying the radio-access technology (RAT) of wireless emitters. The approach improves computational efficiency and accuracy under harsh channel conditions with respect to existing approaches. Intelligent spectrum monitoring is a crucial enabler for emerging wireless access environments that supports sharing of (and dynamic access to) spectral resources between multiple RATs and user classes. Emitter classification enables monitoring the varying patterns of spectral occupancy across RATs, which is instrumental in optimizing spectral utilization and interference management and supporting efficient enforcement of access regulations. Existing emitter classification approaches successfully leverage convolutional neural networks (CNNs) to recognize RAT visual features in spectrograms and other time-frequency representations; however, the corresponding classification accuracy degrades severely under harsh propagation conditions, and the computational cost of CNNs may limit their adoption in resource-constrained network edge scenarios. In this work, we propose a novel emitter classification solution consisting of a Denoising Autoencoder (DAE), which feeds a CNN classifier with lower dimensionality, denoised representations of channel-corrupted spectrograms. We demonstrate—using a standard-compliant simulation of various RATs including LTE and four latest Wi-Fi standards—that in harsh channel conditions including non-line-of-sight, large scale fading, and mobility-induced Doppler shifts, our proposed solution outperforms a wide range of standalone CNNs and other machine learning models while requiring significantly less computational resources. The maximum achieved accuracy of the emitter classifier is 100%, and the average accuracy is 91% across all the propagation conditions.
Current Development and Applications of Super-Resolution Ultrasound Imaging
Authors: Chen Qiyang , Song Hyeju , Yu Jaesok , Kim Kang
Published: April 2021

Abnormal changes of the microvasculature are reported to be key evidence of the development of several critical diseases, including cancer, progressive kidney disease, and atherosclerotic plaque. Super-resolution ultrasound imaging is an emerging technology that can identify the microvasculature noninvasively, with unprecedented spatial resolution beyond the acoustic diffraction limit. Therefore, it is a promising approach for diagnosing and monitoring the development of diseases. In this review, we introduce current super-resolution ultrasound imaging approaches and their preclinical applications on different animals and disease models. Future directions and challenges to overcome for clinical translations are also discussed.
Radiometric Calibration for a Multispectral Sensor Onboard RISESAT Microsatellite Based on Lunar Observations
Authors: Imai Masataka , Kurihara Junichi , Kouyama Toru , Kuwahara Toshinori , Fujita Shinya , Sakamoto Yuji , Sato Yuji , Saitoh Sei-Ichi , Hirata Takafumi , Yamamoto Hirokazu , Takahashi Yukihiro
Published: April 2021

Radiometric calibration utilizing the Moon as a reference source is termed as lunar calibration. It is a useful method for evaluating the performance of optical sensors onboard satellites orbiting the Earth. Lunar calibration provides sufficient radiometric calibration opportunities without requiring any special equipment, and is suitable for nano/microsatellites. This study applies lunar calibration to a multispectral sensor, Ocean Observation Camera (OOC), on board a microsatellite named Rapid International Scientific Experiment Satellite. Simulating the brightness of the Moon based on the RObotic Lunar Observatory and SELENE/Spectrum Profiler models, sensitivity degradation was proven to be negligible in any of the four spectral bands of the OOC with the sensor temperature correction. A bluing trend in the OOC’s sensor sensitivity was revealed, indicating a shorter observation wavelength shows larger irradiance. Comparing the top-of-atmosphere reflectance of Railroad Valley Playa with the Radiometric Calibration Network dataset revealed that the derived calibration parameter from the lunar calibration was valid for correcting the bluing trend in the visible range. Although the lunar and vicarious calibration parameters for the infrared band were unexpectedly inconsistent, lunar calibration could potentially contribute toward estimating the contaminated background radiance in the Earth observation images.
Історико-правовий аспект розвитку законодавства про прототипи органів, що здійснювали нотаріальну діяльність на землях Русі та в Московії
Authors: Чижиков О.
Published: March 2021

У статті здійснено ретроспективний аналіз нормативно-правових положень, які врегульовували первісну нотаріальну діяльність. Розглянуто окремі положення Руської Правди, як базисного акту давньої Русі, а також такі документи Галицько-Волинського князівства – Грамоту князя Івана Ростиславовича (1134 р.), «Рукопісаніє» князя Володимира Васильовича (1287 р.), Уставну грамоту Мстислава Романовича (1289 р.). Надано огляд наукової літератури та правових актів, у яких згадується протореєстраційна діяльність та складання окремих актів приватно-правового характеру так званими майданними піддячими (або скорописцями) в Московії.
Genetic and environmental conditions of aggressive criminal behavior. Methodological and ethical conclusions from pilotage
Authors: Pękala Krzysztof , Kacprzak Andrzej , Chomczyński Piotr , Pękala-Wojciechowska Anna
Published: March 2021

Our research project is framed as biosocial analyzes of the etiology of criminal behavior. This research can be characterized as a conceptually and methodologically innovative attempt to connect the research areas that so far have not been considered together in one project. The research project is based on three components: sociological, psychological, and biological. The main aims of the article are to initiate and facilitate debate concerning the interaction between factors belonging to a variety of different areas and provide an interdisciplinary approach to the study of criminal behavior etiology. A discussion over proveniences of criminal behavior is needed both to enrich consciousness and knowledge about conditions lying under criminal behavior and to reshape practical solutions in the field of social rehabilitation. The article also concerns our methodological and ethical reflections coming from our pilotage project involvement.
Депутатське «волонтерство» як корупційний чинник в органах місцевого самоврядування та одна із загроз національній безпеці України
Authors: Колб О. , Пирожик О.
Published: March 2021

У статті розглянуто питання, пов’язані з волонтерською діяльністю депутатів місцевих рад, визначені проблеми, які детермінують у зв’язку з цим вчинення корупційних правопорушень, а також розроблені відповідні науково обґрунтовані і апробовані зарубіжним досвідом заходи, спрямовані на усунення причин та умов, що сприяють зазначеному суспільно небезпечному явищу.
Кримінально-правова характеристика медичної підстави звільнення від покарання у зв’язку з хворобою
Authors: Поліщук Н.
Published: March 2021

Інститут звільнення від покарання через хворобу складається з двох самостійних підстав звільнення, медичної і правової. Медична підстава звільнення від покарання ділиться на дві окремих,в залежності від типу настання хвороби (психічна чи інша тяжка хвороба) незалежні одна від одної частини, у зв'язку з психічним розладом (ч. 1 ст. 84 КК України) і в зв'язку з іншою важкою хворобою (ч. 2 ст. 84 КК України).
Про деякі особливості обов’язків установ банківської системи України, що стосуються засуджених до покарання у виді позбавлення права обіймати певні посади або займатися певною діяльністю
Authors: Колб Р.
Published: March 2021

У статті, на підставі результатів аналізу змісту визначених у законі обов’язків для установ банківської системи України, що стосуються засуджених до покарання у виді позбавлення права обіймати певні посади або займатися певною діяльністю, визначено їх особливості та проблеми реалізації на практиці, а також запропоновані науково обґрунтовані шляхи щодо їх вирішення по суті.
Належна правова процедура та правові стандарти Європейського суду з прав людини
Authors: Матвєєва Л.
Published: March 2021

У статті досліджуються теоретичні проблеми визначення поняття та змісту належної правової процедури. Висвітлюється концепція належної правової процедури, характеризуються основні етапи її становлення, розвитку та юридичного оформлення. Основні елементи належної правової процедури розкриваються на основі аналізу норм міжнародного, регіонального та національного права. Розглянути найбільш важливі гарантії свободи та недоторканності особи які відображені в міжнародних угодах про права людини та закріплені в конституціях сучасних держав.
Організаційно-правові засади діяльності державної жандармерії Західно-Української народної республіки
Authors: Шкуратенко О. , Прус В.
Published: March 2021

У статті розглянуто історичні передумови утворення та діяльності Державної жандармерії ЗУНР. Детально проаналізовано організаційну діяльність та структуру цього правоохоронного органу. Висвітлено правові основи діяльності Державної жандармерії ЗУНР; її юридичний статус, функції, права та обов’язки. Окремо акцентовано увагу на особливому статусі Державної жандармерії з числа інших правоохоронних органів.
Сталість судової практики як основа розуміння доктрини правового прецеденту
Authors: Бондаренко Є.
Published: March 2021

Досліджується історична основа становлення доктрини правого прецеденту та принципи, що забезпечують його функціонування як джерела права у сучасних правових системах, в тому числі, де він не офіційно не визнається. Судовий прецедент аналізується як основа доктрини правого прецеденту та один з його видів.
Specificity of communication of policemen with persons under the influence of narcotic and psychotropic substances
Authors: Kopencova Dagmar
Published: March 2021

The paper deals with safe communication between members of the Police of the Czech Republic and persons under the influence of narcotic drugs and psychotropic substances. The task of police officers is to maintain public order and monitor and investigate crime. Police officers are front line actors, addressing public crisis situations. They are increasingly confronted with people under the influence of narcotic drugs and psychotropic substances. When investigating crime, they collect information through interrogating suspects, the accused, witnesses and victims who abuse substances. The strategies employed by police officers in interrogating, and communicating with, these people is a key part of their work.
Поняття та ознаки громадського контролю за діяльністю судово-експертних установ України
Authors: Рувін О.
Published: March 2021

У статті наголошено, що здійснення громадського контролю за органами державної влади є важливим чинником побудови громадянського суспільства. Він є одним із дієвих засобів забезпечення відкритості для суспільства діяльності державних інституцій. Незважаючи на те, що у нормативно-правових актах безпосередньо вказується на громадський контроль, однак при цьому нині відсутнє чітке законодавче визначення поняття, а також форм здійснення громадського контролю.
Шляхи вдосконалення правового регулювання непрямих податків
Authors: Когут М.
Published: March 2021

Досліджується проблематика недоліків, які притаманні непрямим податкам та шляхи їх вдосконалення та подолання, в тому числі на прикладі іноземних країн.
Стан наукового дослідження проблеми покарання у виді довічного позбавлення волі
Authors: Марчук В.
Published: March 2021

У статті розкрито стан наукового дослідження проблеми виконання та відбування покарання у виді довічного позбавлення волі. Автором доведено, що сучасна тенденція розвитку вітчизняного кримінального і кримінально-виконавчого законодавства засвідчує поступовий процес гуманізації суспільних відносин у сфері виконання і відбування покарань у виді довічного позбавлення волі, що спирається на європейську модель відбування засудженими цього виду покарання в установах максимального рівня безпеки.
Нагальні проблеми та перспективи розвитку електронного судочинства в Україні
Authors: Зур'ян В.
Published: March 2021

Стаття присвячена дослідженню проблем електронного судочинства в Україні. Виконано огляд загальних проблем інформатизації суспільства та перспектив впровадження електронного правосуддя. Досліджено процес трансформації юридичної діяльності з усталеної системи до комунікаційної моделі, що передбачає оптимізацію бюрократичної процедури та підвищення ефективності судочинства. Проаналізовано вплив пандемії COVID-19, та пов’язаних з нею карантинних обмежень на прискорення процесів розвитку та впровадженню у судову практику сучасних телекомунікаційних технологій. Обґрунтована неможливість судочинства залишатися осторонь новітніх технологій у сучасних реаліях, а тому розвиток електронного судочинства є вагомим фактором забезпечення доступності, прозорості та ефективності правосуддя. Окремо досліджено питання запровадження «електронного суду» як самостійної унікальної форми судового процесу, що забезпечують повний цикл розгляду судової справи в електронному форматі. Доведено існування численних ризиків функціонування інформаційного середовища, але вони жодним чином не зменшують значення інформаційних технологій у вдосконаленні державних інститутів.
Кримінальні правопорушення проти волі, честі та гідності особи: фундаментальне дослідження у кримінально-правовому та кримінологічному вимірі
Authors: Вознюк А.
Published: March 2021

Рец. на кн.: Андрушко А. В. Теоретико-прикладні засади запобігання та протидії злочинам проти волі, честі та гідності особи: монографія. Київ : Ваіте, 2020. 560 .
Конструювання історичного минулого органів державної влади та управління крізь призму сучасних інституційних змін
Authors: Шевченко А.
Published: March 2021

Рецензія на кн.: Дудченко О. С. Конституційно-правові засади створення й функціонування органів державної влади та управління радянської України в 1920-х – першій половині 1930-х років: монографія; за заг. ред. д. ю. н., професора Г. В. Лаврик. Ніжин : НДУ ім. М. Гоголя, 2019. 405 с.
Ukraine – Spain: the archetypes of national characters in the cross-cultural context
Authors: Melnyk Viktoriia
Published: March 2021

The aim of the article. The aim of the research consists in determination of the points of cross-cultural intersection between Ukraine and Spain, in a search of Ukrainian identity in the light of Spanish national character. The research methodology. The absence of the special works, concerned with Ukrainian-Spanish relationships from the point of a cross-cultural dialogue, led to the topic of the research. Certain scholar explorations (such as an essay Que (no) sabemos del romance anonimo of Spanish scholar Santiago Porras Alvarez: 2002) have no significant effect on situation. Comparative analysis is performed by means of several terms, such as “national character” (work of N. Boholiubova and Yu. Nikolaieva, 2009), “archetype” (psychoanalysis of K.G. Jung), “cultural archetype” (article of D. Lvov, 2018), “cross-cultural analysis” (monograph of T. Kornylova, 2014). The results. A certain typological commonness was found through crosscultural comparison of the cultures of Ukraine and Spain. The presented parallels between the archetypical images and their main place in the mindsets of both peoples have opened up new horizons for further research. Restoration of the concept of the Ukrainian national character, its integral image still requires time, research interest and crystallization. However, we were able to find the core features in the system of mindset formation, such as feminocentricity, apocalection and mystical shade of a worldview, religious commitment, valiance and militancy. Novelty. In the article, for the first time not only on the territory of the Ukrainian music studies, but also in the world, it is proposed to draw an analogy between the representation of the national character in the culture of Ukraine and Spain on the basis of typological commonness of “cultural archetypes”, which are at the bottom of the manifestation of the national identity of two European countries. The practical significance. Comparison of cultural achievements of Ukraine and Spain (music, literature, folklore) to a certain extent cleared the understanding of the Ukrainian national character from “Little Russian depositions”, using the Spanish phenomenon as a symbolic “Other”.
Stages of development and typological features of solo perfomance of the Kharkiv button accordion (bayan) school
Authors: Snedkov Igor , Snedkova Lyudmila
Published: March 2021

Background. The article tells about solo performer’s creativity of accordion player of Slobozhanchina region, which is an inherited constituent of pedagogical activity. The relevance of a study is shown through regarding of historical stages of creation of tradition of solo concerto activity of the leading performers on button accordion in the artistic higher education establishments of Slobozhanchina region. The experience of concert form of making music by the accordion players in the region Slobozhanchina has not yet become an object of special treatment and systematisation and therefore calls for throughout profound investigation. Theoretical background. Performers activity of teachers of Department of folk instruments is revealed in works by such scholars as M. Davydova (2005), T. Bolshakova (1992), V. Zelenuk (2010), M. Imkhanitsky (2001), Yu. Loshkov (2008), L. Ponikarova (2004), A. Semeshko (2009), L. Snedkova (2013), V. Pluzhnikov (2016), A. Svetov (2009) etc. Researchers novelty of this study is caused by lack of fundamental and systematical works devoted to exploration of regional specific of stages of creation of solo concert button accordion performance of Slobozhanchina region. The authors regard events of regional meaning, which caused their influence on the changes into process is of performance on button accordion and give a chronology of creation of professional education in educational institutions of different levels, reveal personal role of renowned performers in propagation of the performance on the button accordion. The aim and the task of the research is to define stages of creations of solo concert musician activity of button accordion player of the Slobozhanchina region and reveal their regional peculiarities on the example of experience of professors of Department of folk instruments of Ukraine in Kharkiv I. P. Kotlyarevsky National University of Arts. Conclusions. The research defines 4 main stages of development and outlines typological traits of Kharkiv button accordion school: 1) high level of technical skills as attribute of professional performance on button accordion which is conjoined by expense by extensive emotional expression; 2) specific system of means of play on the accordion, the freedom of fingering, independence of right and left hands, technological leading of the instruments, chord technique which is characterised by soft progressions through joining of vertical and horizontal layers; 3) tradition of interaction between the performers and composers which are capable of playing the folk instruments including button accordion and actively composing for them; 4) culture of ensemble hearing and musical intellect which are characteristic for specific of folklore instrumental music Modern folklore instrumental music of Slobozhanchina region is characterised by overall inclination of the musicians too satisfy demand of objectively existing performance culture.
Song and dance genre specifics in works for button accordion by the composers of the Department of Folk Instruments of Ukraine of Kharkiv I. P. Kotlyarevsky National University of Art
Authors: Ptashenko Serhii
Published: March 2021

Recent years have provoked an increasing interest in button accordion arts of Ukraine therefore a great demand for button accordion performance based on song and dance genre features is to be of great importance. Our research work deals with the embodiment of the song and dance genres features in academic button accordion art. The above-mentioned phenomenon has led to the appropriate systematization of their transformations in the musicological viewpoint therefore is stated to be very novel. This systematization is revealed from stylization to various arrangements, further transcriptions, fantasies, paraphrases, works on the theme of other artists that is to create the genre-style transformation. The aim of the research is to determine the genre-style methods of composers’ work for button accordion on the basis of song and dance genre. Present scientific research scope led to the solution of the following tasks: the disclosure of methods of author’s song and dance originals processing, identifying the specifics of drama and means of musical expression, justifying the popularity of works in the domestic musical performance. The following methods are used: analytical, comparative-historical and structural-functional. Summing up the results, it can be concluded that stylizations of dance and song genre are stated to be a great component of button accordion art. The use of European modeling samples (gavotte, mazurka and musette) contributed to the button accordion performance leading to sound production sophistication, high refinement of the sound palette and dynamic nuance, which enriched the artistic means of expressiveness, contributed to the evolution of interpretive experience. In the arrangements and transcriptions (by other authors) of Latin American dance genres there was an enrichment of rhythmic intonation structures and timbre palette of the instrument that lead to great popularity among performers and listeners by the interaction of academic art and genres belonging to the ‘third layer’. Among the opuses created in the genre-style transformation of songs and dances, the re-intonation of the original musical compositions received high artistic results. The use of modern means of button accordion expression, construction of new musical forms, application of elements of musical polystylistics, modification of genres are aimed at multifaceted reproduction of the figurative content of the original source, giving it a new artistic value and concert life. In the musical works of button accordion composers, the direction of song and dance genres features continuously enriches the quantitative and qualitative musical literature, so the prospects for further scientific research are relevant and promising.
Some aspects of the origin of bandura fingering in the twentieth century as a fundamental basis of performance techniques
Authors: Mokroguz Inna
Published: March 2021

Background. This article studies the stages of formation of bandura fingering in the twentieth century, analyzes the scientific and methodological literature, that has been the basis for the professional growth of the first bandura performers. The paper highlights fundamental methodological principles that contributed to the technical development and professional skills improvement of the future bandura performer. The article defines the main components of the “bandura school” of the past century, analyzes the basic approaches of professional authors to fingering, fingering combinations and fingering inversions on the bandura and highlights the relevance of their application in modern bandura performance. The study defines the significant professional fingering variants from the past and their importance in the present performance. Methods. In the early twentieth century, there has been a need of professional bandura training and educational textbooks that would promote self-learning of the instrument. As a response to the request of M. V. Lysenko, the famous bandura player from Kharkiv Hnat Khotkevych published the first “Bandura textbook” (Lviv), which promotes the ten-finger performing system, the Kharkiv-type of playing and offers a large number of exercises and technical repertoire, paying special attention to various fingering combinations and position of fingers on the string. The activity of M. Opryshko played a significant role in Ukrainian kobzar art. The “Bandura School” by V. Kabachko and E. Yutsevich is a textbook for primary education. Zinovy Shtokalko, a well-known bandura player of his time, created the “Kobzar textbook”, in which he promotes the Kharkiv-way of playing and professional bandura performance. Notably, due to the transition from the Kharkiv-type to the Kyiv-type banduras, both the technical and artistic expressive capabilities of the instrument have significantly deteriorated. While selecting the educational material, there should be an organic link between the development of students’ musical hearing, new performance techniques and familiarity with musical literacy. Of particular importance, here is the work on improving the artistic quality of performances, the development of students’ artistry. Conclusions. The issue of technical development of the bandura instrumental performer is linked to the problem of fingering. During the twentieth century, many teachers and researchers developed the necessary methodological basis, which became the foundation for the gifted generation of bandura performers. That is why, bandura fingering issue requires deep analysis and thorough review of existing developments, the search for new approaches and their practical implementation.
Specifics of the structure of the cycle and the musical form in the Concerto for Persian Ney and Orchestra «Toward That Endless Plain» by Reza Vali
Authors: Tavakkol Ehsan
Published: March 2021

The article considers the peculiarities of the structure of the cycle and the form of the Concerto for the Persian Ney with Orchestra «Toward That Endless Plain» by the modern Iranian-American composer of the XX–XXI centuries Reza Vali (b. 1952). It was found that the unusual structure and musical form of this Concert are manifested in the combination between traditional Western European principles of cycle composition with the principles of musical form each part that is characteristic of classical Iranian music. The cycle of the Concerto is three-part with additional sections. This model of a solo concerto has developed in the European musical tradition. However, due to the author’s program the structure of the cycle, in general, is extremely specific (Tavakkol, 2019: 271). It was found that the specifics of the structure of the cycle is the introduction of two additional sections, marked as “Prelude” (set out before Part I) and “Interlude” (placed between Parts II and III). It is established that each of the three parts and additional sections are set out in a peculiar form inherent in Iranian classical music: Parts I and III are composed in mosaic form, Part II is written in the form of nobats; “Prelude” and “Interlude” are created in Ternary form. It is revealed that the arched principle (the principle of symmetry) in the construction of the cycle is found between “Prelude” and “Interlude”, as well as between I and III parts. The alternation of tempo characteristics of the parts is revealed in the general composition of the cycle. The I and III parts have a slow tempo and the II part has a fast. (this kind of contrast between parts is not typical for the genre of a solo concert of Western European music). Two principles in the organization of the composition cycle and the form of individual parts are highlighted. It is proved that R. Vali’s choice of a specific composition of the cycle, the form of parts and additional sections, as well as the use of tempo of each part, is due to the concert program, which is a kind of interpretation of the meaning contained in the poem by S. Sepehri. The music of the work is closely connected with the program. All parts of the Concerto have titles in Persian and English, which are based on the postulates of mystical philosophy and Sufism. Prelude and Interlude, which are associated with images of the material world – aggression and war. In comparison with the saturated, solid sound of the Prelude and Interlude, the delicate sparsity of the three main parts of the cycle are meant to reveal the spiritual life of humanity (Tavakkol, 2020: 113–117).
Cancerous Tissue Diagnosis by LIF Spectroscopy Derived From Body-Compatible Fluorophores
Authors: Asghari Moghaddam Atefeh , Sajad Batool , Mehrad Nia Fariba , Madani Seyed Hamid
Published: March 2021

Introduction: The laser-induced fluorescence (LIF) method as molecular emission spectroscopy is used to diagnose cancerous tissues. According to the previous reports, the red-shift in the fluorescence spectrum from Rhodamine 6G (Rd6G)-stained cancerous tissues compared to healthy ones impregnated with the same dye provides the feasibility for diagnosis. In this paper, we have employed the LIF emissions as a diagnostic method to distinguish between cancerous and healthy tissues infiltrated by a body-compatible fluorophore to avoid the toxicity and hazard of Rd6G dye. Methods: Biological tissue specimens are stained with sodium fluorescein (NaFl) dye and then irradiated by the blue CW diode laser (405 nm) to examine the spectral properties that are effective in detecting cancerous tissues. Results: The spectral shift and the intensity difference of fluorescence are keys to diagnosing in vitro cancerous breast, colon, and thyroid tissues for clinical applications. The notable tubular densities in the breast and colon tissues and the space between the papillae in the thyroid ones cause the cancerous tissues to be prominently heterogeneous, providing numerous micro-cavities and thus more room for dye molecules. Conclusion: Here, we have assessed the spectral shift and intensity difference of fluorescence as a diagnostic method to distinguish between cancerous and healthy tissues for clinical applications.
Infrared Thermography in the Evaluation of Dental Socket Healing After Photobiomodulation Therapy: A Case Report
Authors: Carvalho Giovanna Rodrigues de , Rodrigues Wictor Nogueira , Barboza João Victor Melo , Nery Cláudio de Góis , Moreira Francine do Couto Lima , Roriz Virgílio Moreira
Published: March 2021

Introduction: The aim of this article was to evaluate the efficacy of photobiomodulation therapy (PBMT) in the alveolar tissue healing process post-extraction using infrared thermography (IT). Case Presentation: A 36-year-old male patient had teeth extractions (18 and 28). Four PBMT sessions (660 nm; 2 J per tooth) were performed in the region of tooth 28 and recorded with thermographic images to compare the healing process, bilaterally. In the first two postoperative sessions, the temperature was higher (hyperradiant) on the left side (treated). After the third laser application, the left side was hyporradiant. In later session, the treated side became hyperradiant compared to the control side. The alveolus of tooth 28 showed more rapid healing than tooth 18 over a period of 60 days. Conclusion: IT can be used to detect the favorable effect of PBMT on accelerating the healing process in the alveolus within 60 days after the tooth extraction.
Photodynamic Therapy as an adjunct in the Treatment of Medication-Related Osteonecrosis of the Jaw: A Case Report
Authors: Almeida Marcelo Vieira da Costa , Moura Antonio C. , Santos Lúcia , Gominho Luciana , Cavalcanti Ully Dias Nascimento Távora , Romeiro Kaline
Published: March 2021

Introduction: Medication-related osteonecrosis of the jaw (MRONJ) corresponds to an adverse effect of the use of drugs such as bisphosphonates and denosumab. This condition is often associated with pain, infection, purulent secretion, paraesthesia, tooth mobility and halitosis, decreasing the patient’s quality of life. The management of MRONJ tends to be conservative, through the guidance of oral hygiene, antibiotic therapy and mouthwashes. However, the use of antimicrobial photodynamic therapy (aPDT) has shown promise in the treatment of these injuries. The purpose of this article is to report a case of MRONJ treatment associated with aPDT. Case Report: A 75-year-old patient, with a history of breast cancer and use of intravenous Zoledronic Acid, presented with bilateral MRONJ lesions in tuberosity on the right and left sides. Treatment was conservatively instituted with the use of aPDT as an adjuvant. After 12 aPDT sessions, complete regression of the lesion was observed. However, after two weeks, the presence of a new lesion was noted, this time in the anterior region of the maxilla. The same protocol previously established was followed and after two aPDT sessions, the patient returned with complete lesion regression. Conclusion: The use of aPDT may represent an important adjuvant within a set of clinical protocols in the treatment of MRONJ.
Effects of Diode and Nd:YAG Laser Irradiation on Friction Forces Between Two Types of Ceramic Brackets and Rhodium-Coated Archwires
Authors: Ghadirian Hannaneh , Geramy Allahyar , Keshvad Mohammad Ali , Heidari Soolmaz , Chiniforush Nasim
Published: March 2021

Introduction: Ceramic brackets have gained increasing popularity among dental clinicians and orthodontic patients but friction is a major concern when using them. This study sought to assess the effects of diode and Nd:YAG (neodymium-doped yttrium aluminum garnet) laser irradiation on friction forces between two types of ceramic brackets and rhodium-coated esthetic archwires. Methods: Thirty polycrystalline and 30 poly-sapphire brackets were divided into 6 groups (n=10) as follows: (I) control polycrystalline brackets (no laser irradiation), (II) polycrystalline brackets subjected to diode laser irradiation, (III) polycrystalline brackets subjected to Nd:YAG laser irradiation, (IV) control poly-sapphire brackets (no laser irradiation), (V) poly-sapphire brackets subjected to diode laser irradiation, and (VI) poly-sapphire brackets subjected to Nd:YAG laser irradiation. The bracket slots were laser-irradiated on a custom-made table. Sixty 5-cm pieces of rhodium-coated archwires were used for the friction test in a universal testing machine at a speed of 10 mm/min. Ten brackets from the six groups underwent scanning electron microscopy (SEM), X-ray diffraction (XRD) and energy-dispersive X-ray spectroscopy (EDX). Results: The frictional resistance value of polycrystalline brackets was significantly higher than that of poly-sapphire brackets, irrespective of laser type (P<0.05). Irradiation of diode and Nd:YAG lasers, compared with the control group, had no significant effect on friction, irrespective of bracket type (P>0.05). Conclusion: It appears that diode and Nd:YAG laser irradiation cannot significantly decrease the friction. Future studies are warranted on different laser types with variable exposure.
Florbela Espanca: a construção erótica, panteísta e saudosista do Alentejo em sua obra
Authors: Freitas de Farias Priscilla
Published: March 2021

Os olhos de um poeta são especiais. Eles permitem enxergar o mundo de um modo diferente da maioria das pessoas, às vezes mais triste, noutras mais bela, mas certamente as cores da vida assumem tom único, apenas superficialmente captado por muitos daqueles que se permitem mergulhar nos versos dessas pessoas especiais. Florbela Espanca tem destaque no cenário literário português não apenas pela beleza de sua obra, mas pela forma como viveu. Seus versos refletem a intensidade de sua vida, movida por paixões, no sentido puro do termo, que consomem seu portador. E um dos vieses de sua obra é exatamente a reelaboração simbólica de sua terra natal, retratada em sua poesia de forma singular, de certo modo espelhando as ações da autora.
Evaluation of Buildings and Building Physics Master's Thesis in Architectural Education in Turkey
Authors: AYDIN Özlem , İSMAİLOĞLU Semiha , AKKAN Ayça , ŞANLI Ebru
Published: March 2021

The study aims to create a resource by scanning the data on Masters theses on construction and building physics under the department of architecture in universities in Turkey between 2000 and 2018. The study is important because there are currently no printed and digital literature reviews on this subject available. The sampling of the study consists of Master’s theses from the department of architecture in the HEC National Thesis Center system. In the study, were examined 850 accessible Master's theses on the topic of construction and building physics from the departments of architecture of universities in Turkey. The language, year, city, university, title, method, and keywords of the theses were evaluated using a bibliometric and content analysis method. In this context, the study aims to create a source for the research and to guide the selection of methods and topics. It was observed that the subjects addressed in the theses from the construction technology department in architecture at a graduate education level vary depending on the developing technology and needs, and studies on energy and acoustics have increased.