bluuebunny/crossref_metadata_2025 huggingface dataset:
Advancements in Indoor Precision Positioning: A Comprehensive Survey of UWB and Wi-Fi RTT Positioning Technologies
Authors: Qiao Jiageng , Yang Fan , Liu Jingbin , Huang Gege , Zhang Wei , Li Mengxiang
Published: December 2024

High-precision indoor positioning is essential for various applications, such as the Internet of Things, robotics, and smart manufacturing, requiring accuracy better than 1 m. Conventional indoor positioning methods, like Wi-Fi or Bluetooth fingerprinting, typically provide low accuracy within a range of several meters, while techniques such as laser or visual odometry often require fusion with absolute positioning methods. Ultra-wideband (UWB) and Wi-Fi Round-Trip Time (RTT) are emerging radio positioning technologies supported by industry leaders like Apple and Google, respectively, both capable of achieving high-precision indoor positioning. This paper offers a comprehensive survey of UWB and Wi-Fi positioning, beginning with an overview of UWB and Wi-Fi RTT ranging, followed by an explanation of the fundamental principles of UWB and Wi-Fi RTT-based geometric positioning. Additionally, it compares the strengths and limitations of UWB and Wi-Fi RTT technologies and reviews advanced studies that address practical challenges in UWB and Wi-Fi RTT positioning, such as accuracy, reliability, continuity, and base station coordinate calibration issues. These challenges are primarily addressed through a multi-sensor fusion approach that integrates relative and absolute positioning. Finally, this paper highlights future directions for the development of UWB- and Wi-Fi RTT-based indoor positioning technologies.
Neuraxial Anesthesia and Risk of Root Damage: A 3D Ex Vivo Study
Authors: Labandeyra Hipólito , Sala-Blanch Xavier , Prats-Galino Alberto , Puigdellívol-Sánchez Anna
Published: December 2024

Cauda equina nerve roots may become damaged during neuraxial anesthesia, and post-puncture headache may appear in the case of cerebrospinal fluid leakage if needle tips are deformed due to bone contact when several attempts are needed. Our aim was to verify the correlation between skin–transverse process distance (st) and skin–dural sac distance (d) for calculation of optimal angles in a free visual guide and as a reference for the maximal depth to be traversed by the needle. Randomly selected ex vivo samples (n = 10) were flexed to reproduce the position of the lumbosacral spine during spinal anesthesia. Spinal needles were inserted perpendicular to the skin either blindly or following the inferred paramedian angle corresponding to ultrasound-measured (d). After computed tomography and three-dimensional reconstruction, both (st) and (d) were measured, and the Pearson correlation index was calculated. A free 3D-PDF tool was used to illustrate the potential affectation of nerve cuffs by needles located lateral to the dural sac. Correlation between (d) and (st) was 0.84–0.93 at L4L5-L3L4 intervertebral levels, and most needle tips were located within the spinal canal, but some traversed the zone where nerve cuffs emerge. In conclusion, ultrasound may determine if a perpendicular needle insertion is viable at midline. If not, the optimal paramedian angle and maximal depth may be determined by measuring (st).
The Contribution of Free Sugars to Energy Intake in Mid to Late Childhood: Comparisons Between Nutrient and Food Group Intakes and Antecedents of Diets High and Low in Free Sugars
Authors: Emmett Pauline , Taylor Caroline
Published: December 2024

Background/Aims: High intakes of free sugars may have negative effects on health perhaps associated with their effect on nutrient and food group intakes. The primary aim of the study was to compare nutrient and food group intakes between children with habitual high or low intakes of free sugars to identify which foods could be targeted to improve the diets of children consuming excess free sugars. The secondary aim was to assess antecedents for a child being in the high free sugars group compared with the low to identify the age at which an intervention would be most effective. Methods: The Avon Longitudinal Study of Parents and Children collected 3-day food records from children at ages 7, 10, and 13 years. Increments of 5% of energy from free sugars (%E-FS) were calculated. Two groups of children were identified: those consuming ≤15%E-FS each time (Low-FS) and those consuming >20%E-FS each time (High-FS). Their mean daily nutrient and food group intakes were compared at each age using ANOVA. Antecedents of being in these two FS groups were tested using regression models. Results: At each age, 70% of children consumed >15%E-FS with one-third >20%E-FS. Data were available for 4723 children at all three ages, and the diets of the 456 children with Low-FS intakes were compared with 330 children with High-FS intakes at each age. Energy intakes were higher in High-FS than Low-FS at each age, but protein, fat, starch, and fibre intakes were lower. Several micronutrient intakes (e.g., calcium, zinc, selenium, and retinol) were also lower. The High-FS group ate more confectionery and other sweet foods than the Low-FS group as well as six times more sugar-sweetened soft drinks (SSSD) and four times more fruit juice. However, the High-FS group consumed less bread, fat spreads, milk, and vegetables than the Low-FS group. Being in the High-FS group compared with Low-FS group was not associated with maternal education, age, or breastfeeding duration. It was more likely if the child was difficult to feed at 15 months or a picky eater in preschool years and if a dietary pattern low in nutrient-dense core foods and high in nutrient-poor discretionary foods was being consumed at 2 and/or 3 years of age. Conclusions: Children who habitually ate a High-FS diet in mid-late childhood consumed larger amounts of SSSD and fruit juice and less of some core foods than Low-FS consumers. This type of dietary pattern was already evident at 2 years of age and was associated with being a picky eater. To reduce children’s intake of free sugars, support for parents to introduce a healthy balanced diet should be provided in the first 2 years of a child’s life.
Analysis of Usual Consumption of Vitamin D Among Adult Individuals in Italy
Authors: Nuti Ranuccio , Gennari Luigi , Cavati Guido , Caffarelli Carla , Frediani Bruno , Gonnelli Stefano , Catalano Antonino , Francucci Cristiano Maria , Laurentaci Concetta , Letizia Mauro Giulia , Malavolta Nazzarena , Mazzantini Maurizio , Minisola Giovanni , Russo Raffaella , Sabatino Pasquale , Pinto Monica , Salomone Sergio , Tei Luciano , Vescini Fabio , Xourafa Anastasia , Cartocci Alessandra , Lo Conte Sofia , Merlotti Daniela
Published: December 2024

Background: The condition of vitamin D (25OHD) deficiency represents an important public health problem. In Europe, hypovitaminosis is common not only in the elderly population but also between 50 and 70 years, both in males and females. Data regarding vitamin D intake in the Italian population are very limited. In a recent paper, reporting data collected by a specific Frequency Food Questionnaire (FFQ), we observed in a small group of healthy subjects that the dietary consumption of vitamin D, both in females and males, was far below the average. Methods: With the aim of expanding our preliminary data, we conducted a survey on a large cohort of subjects from different areas of Northern, Central, and Southern Italy. The FFQ contained 11 different questions regarding the amount and type of intake of foods containing ergocalciferol and cholecalciferol. It was submitted to 870 subjects, 627 females and 243 males, with an age range from 40 to 80 years; 31.6% of the studied population was apparently in good health, while 68.4% were affected by different pathologies. Results: The present data confirm previous observations: the global quantity of vitamin D intake in 14 days was 70.8 μg (±1.8 SE, ±54.4 SD) in females and 87.5 μg (±1.9 SE, ±57.1 SD) in males; the mean daily intake of vitamin D in females and males was 5.05 μg (±0.5 SE, ±3.8 SD) and 6.25 μg (±0.21 SE, ±4.1 SD), respectively. In healthy subjects, a gradual decrease was observed in the overall intake of vitamin D in both females and males according to an increase in age bracket, ranging from 74.5 μg and 103.8 μg in the 40–50 age group to 54.5 μg and 87.8 μg in the 71–80 age group, respectively. Conclusions: In conclusion, the present data, collected in a large Italian cohort, underscore that the daily intake of vitamin D is far below the recommended daily average, thereby contributing to the development of potential hypovitaminosis.
Identification of Causal Genes and Potential Drug Targets for Restless Legs Syndrome: A Comprehensive Mendelian Randomization Study
Authors: Qian Ruiyi , Zhao Xue , Lyu Dongbin , Xu Qingqing , Yuan Kai , Luo Xin , Wang Wanying , Wang Yang , Liu Yutong , Cheng Yu , Tan Yingting , Mou Fan , Yuan Chengmei , Yu Shunying
Published: December 2024

Background: Restless legs syndrome (RLS) is a common sensorimotor sleep disorder that affects sleep quality of life. Much effort has been made to make progress in RLS pharmacotherapy; however, patients with RLS still report poor long-term symptom control. Methods: Comprehensive Mendelian randomization (MR) was performed to search for potential causal genes and drug targets using the cis-pQTL and RLS GWAS data. Robustness was validated using the summary-based Mendelian randomization (SMR) method and co-localization analysis. Further evidence of pleiotropy of the target genes and their potential side effects was provided by phenome-wide MR analysis (MR-PheWAS). Finally, molecular docking simulations were conducted on drug candidates corresponding to these targets, which revealed promising binding affinities and interaction patterns and underscored the druggable potential of the target gene. All of the analyses above were conducted in the context of Homo sapiens. Results: MAN1A2 showed a statistically significant result in the MR analysis, which was validated through SMR and co-localization analysis. The MR-PheWAS showed a low probability of pleiotropy and prospective side effects. Molecular docking was used to visualize the binding structure and fine affinity for MAN1A2 and the drugs predicted by DSigDB. Conclusions: Our study provides comprehensive evidence supporting MAN1A2 as a promising causal gene and therapeutic target for RLS, offering insights into the underlying molecular mechanisms and paving the way for future drug development efforts.
Real-Life Data on the Safety of Pasireotide in Acromegaly: Insights from EudraVigilance
Authors: Popa Ilie Ioana Rada , Dobrea Carmen Maximiliana , Butuca Anca , Homorodean Calin , Morgovan Claudiu , Vonica-Tincu Andreea Loredana , Gligor Felicia Gabriela , Ghibu Steliana , Frum Adina
Published: December 2024

Background/Objectives: Pasireotide (PAS) is a somatostatin receptor ligand (SRL) used to treat acromegaly, a chronic condition caused by excess growth hormone. While it offers significant benefits as a second-line treatment for uncontrolled acromegaly, its use raises major concerns due to hyperglycemic side effects and gastrointestinal issues, the latter being similar to those seen with first-generation SRLs. The aim of this study is to evaluate the real-world evidence on adverse drug reactions (ADRs) reported for PAS in the EudraVigilance database, in comparison to other established drug-based therapies for acromegaly. Methods: A descriptive analysis and a disproportionality analysis were conducted. Results: The fewest individual case safety reports (ICSRs) and adverse drug reactions (ADRs) were reported for PAS, with 698 (4%) ICSRs and 1,647 (4%) ADRs, which is even lower than for pegvisomant (PEG), which had 1765 (11%) ICSRs and 4842 (10%) ADRs. Both PAS and lanreotide (LAN) exhibited the lowest proportion of cases classified as serious. Among the total reported ADRs, those categorized as “Metabolic and nutrition disorders” were most frequent and severe for PAS (PAS—17.5% vs. OCT—4.6%, LAN—4.5%, and PEG—2.7%). Additionally, PAS demonstrated a higher likelihood of reporting endocrine disorders, which were frequently classified as serious, as well as stones affecting the hepatobiliary system compared to other drugs. Conclusions: Although PAS had the fewest ICSRs and ADRs, and less frequent serious ADRs, it had more reports frequently classified as serious in the “Metabolism and Nutrition Disorders” category (including events such as elevated blood glucose levels or diabetes) and “Endocrine Disorders” category compared to other SRLs and PEG. Furthermore, there was a higher likelihood of reporting hepatobiliary stones with PAS compared to OCT and PEG. This highlights the importance of adequately monitoring glycemic control and the biliary tract through ultrasound at the initiation and during follow-up of PAS therapy. Improved monitoring and reporting of these ADRs could enhance care for patients with acromegaly.
Eutectogel-Based Drug Delivery: An Innovative Approach for Atenolol Administration
Authors: Cassano Roberta , Sole Roberta , Siciliano Carlo , Baldino Noemi , Mileti Olga , Procopio Debora , Curcio Federica , Calviello Gabriella , Serini Simona , Trombino Sonia , Di Gioia Maria Luisa
Published: December 2024

Background: Hypertension affects 32% of adults worldwide, leading to a significant global consumption of cardiovascular medications. Atenolol, a β-adrenergic receptor blocker, is widely prescribed for cardiovascular diseases such as hypertension, angina pectoris, and myocardial infarction. According to the Biopharmaceutics Classification System (BCS), atenolol belongs to Class III, characterized by high solubility but low permeability. Currently, atenolol is commercially available in oral formulations. Increasing attention is being directed towards developing cost-effective transdermal delivery systems, due to their ease of use and better patient compliance. Eutectogels represent next-generation systems that are attracting great interest in the scientific community. Typically obtained from deep eutectic solvents (DESs) combined with gelling agents, these systems exhibit unique properties due to the intrinsic characteristics of DESs. Methods: In this study, a DES based on choline chloride as a hydrogen bond acceptor (HBA) and propylene glycol as a hydrogen bond donor (HBD) was explored to enhance the topical delivery of atenolol. The solubility of atenolol in the DES was evaluated using spectroscopic and thermodynamic measurements which confirmed the formation of hydrogen bonds between the drug and DES components. Additionally, the safety of the DES was assessed in a cell viability assay. Subsequently, we formulated eutectogels with different concentrations using animal gelatin and Tego Carbomer 140, and characterized these formulations through rheological measurements, swelling percentage, and permeation studies with Franz cells. Results: These novel eutectogels exhibit superior performance over conventional hydrogels, with a release rate of approximately 86% and 51% for Carbomer- and gelatin-based eutectogels, respectively. In contrast, comparable hydrogels released only about 27% and 35%. Conclusions: These findings underscore the promising potential of eutectogels for the transdermal delivery of atenolol.
Integration of Ontogeny-Based Changes for Predicting the Exposure of Diphenhydramine in the Pediatric Population: A PBPK Modeling Approach
Authors: Zamir Ammara , Rasool Muhammad Fawad , Alqahtani Faleh , Alqhtani Hussain , Ahmad Tanveer
Published: December 2024

Background: Diphenhydramine is an anti-tussive used periodically to treat seasonal colds, contact dermatitis, and anaphylactic reactions. This study aimed to develop a physiologically based pharmacokinetic (PBPK) model of diphenhydramine in predicting its systemic exposure among healthy pediatrics (children and adolescents) by leveraging data files from adults (young and elderly). Methods: The data profiles comprising serum/plasma concentration over time and parameters related to diphenhydramine were scrutinized via exhaustive literature analysis and consolidated in the PK-Sim software version 11.1. This modeling methodology commences with developing an adult model and then translating it to the pediatrics which compares the predicted concentration–time datasets with the reported values. Results: The accuracy of model anticipations was then assessed for each pharmacokinetics (PK) variable, i.e., the area under the curve from 0 to infinity (AUC0-∞), maximal serum/plasma concentration (Cmax), and clearance of the diphenhydramine in plasma (CL) by employing the predicted/observed ratios (Rpre/obs), and average fold error (AFE), which fell within the pre-defined benchmark of 2-fold. The predicted and observed Cmax values for pediatrics were 3-fold greater in comparison to the young adults following a 25 mg dose depicting a need to monitor dosage schedules among children closely. Conclusions: These model-based anticipations confirmed the authenticity of the developed pediatric model and enhanced the comprehension of developmental variations on PK of diphenhydramine. This may assist healthcare professionals in ensuring the significance of lifespan applicability in personalized dose regimens, promoting therapeutic efficacy and minimizing side effects in chronic conditions among children.
Fluconazole-Resistant Vulvovaginal Candidosis: An Update on Current Management
Authors: Akinosoglou Karolina , Livieratos Achilleas , Asimos Konstantinos , Donders Francesca , Donders Gilbert G. G.
Published: December 2024

Currently, the rising prevalence of resistant Candida species, particularly Candida albicans, as well as non-albicans isolates such as Candida glabrata and Candida krusei, represent challenges in their management. In this review, we aimed to explore the current management of fluconazole-resistant vulvovaginal candidiasis (FRVVC). Identified studies focused on alternative antifungal therapies, including boric acid, nystatin, and newer agents like oteseconazole and ibrexafungerp. The findings highlight the need for tailored treatment regimens, considering the variability in resistance patterns across regions. Unprofessional as well as professional overuse of antifungals for vulvovaginal symptoms that are not caused by Candida infections should be combatted and banned as much as possible. Instead of high-dose maintenance regimens using weekly doses of 150 to 200 mg of fluconazole for 6 months or longer, it is advisable to use an individualised degressive regimen (ReCiDiF regimen) in order to tailor the treatment of a particular patient to the lowest dosage possible to keep the diseases controlled. Additionally, this report underscores the impact of antibiotic use on the microbiota, which can raise the possibility of VVC and lead to fluconazole resistance, emphasizing the necessity for cautious antibiotic prescribing practices.
Twisted Multi-Cosine Gaussian Schell-Model Arrays and Their Statistical Characteristics
Authors: Tang Miaomiao , Dong Shijie , Yuan Pengju , Yang Yunzhe , Zhou Yujie , Li Xinzhong
Published: December 2024

A novel class of random sources with a twisted multi-cosine Gaussian Schell model correlation function is introduced, termed the TMCGSM array. The spectral density and spectral degree of coherence of the TMCGSM array field upon propagation are investigated thoroughly. Numerical examples illustrate that such beams are capable of producing a non-uniform lattice profile in the far zone and exhibits an unusual rotation behavior. It is revealed that the twist factor can not only induce the array to rotate as a whole, but also has a modulation effect on the intensity of element lobes in the central area. We also demonstrated that an obvious twist effect could be observed in the coherence curves under certain conditions.
Predicting Surface Roughness and Grinding Forces in UNS S34700 Steel Grinding: A Machine Learning and Genetic Algorithm Approach to Coolant Effects
Authors: Dehghanpour Abyaneh Mohsen , Narimani Parviz , Javadi Mohammad Sadegh , Golabchi Marzieh , Attarsharghi Samareh , Hadad Mohammadjafar
Published: December 2024

In today’s tech world of digitalization, engineers are leveraging tools such as artificial intelligence for analyzing data in order to enhance their capability in evaluating product quality effectively. This research study adds value by applying algorithms and various machine learning techniques—such as support vector regression, Gaussian process regression, and artificial neural networks—on a dataset related to the grinding process of UNS S34700 steel. What sets this study apart is its consideration of factors like three types of grinding wheels, four distinct cooling solutions, and seven varied depths of cut. These parameters are assessed for their impact on surface roughness and grinding forces, resulting in the conversion of information into insights. A relational equation with 25 coefficients is developed, using optimized algorithms to predict surface roughness with an 85 percent accuracy and grinding forces with a 90 percent accuracy rate. Learning from machine models like the Gaussian process regression exhibited stability, with an R2 value of 0.98 and a mean accuracy of 93 percent. Artificial neural networks achieved an R2 value of 0.96, and an accuracy rate of 90 percent. These findings suggest that machine learning techniques are versatile and precise when dealing with datasets. They align well with digitalization and predictive trends. In conclusion; machine learning provides flexibility and superior accuracy for predicting data trends compared to the formulaic approach, which is contained to existing datasets only. The versatility of machine learning highlights its significance in engineering practices for making data-informed decisions.
The Genus Lophiolepis Is at Least as Well Supported as Afrocarduus, Afrocirsium, and Nuriaea. Comment on Moreyra et al. African Mountain Thistles: Three New Genera in the Carduus-Cirsium Group. Plants 2023, 12, 3083
Authors: Del Guacchio Emanuele , Zedek František , Caputo Paolo , Iamonico Duilio , Bureš Petr
Published: December 2024

Moreyra and co-authors, in their recent paper published in Plants, presented a desperately needed Hyb-Seq phylogeny of the genus Cirsium sensu lato. Through their findings, they provided a critical assessment of an earlier proposal of ours to separate Cirsium sect. Eriolepis and Cirsium italicum into the genera Lophiolepis and Epitrachys, respectively. While we fully respect their right not to accept our proposal, we cannot remain silent to their arguments that not only misinterpret our findings and statements but are often in direct conflict with their own results that actually support our proposal to segregate Lophiolepis. In addition, as Moreyra and co-authors did not include Epitrachys italica (formerly Cirsium italicum) in their analyses; they have no basis for arguing in favour or against our proposal to separate it as a monotypic genus. Finally, we conclude that the genus Cirsium, as circumscribed by the above-mentioned authors (i.e., including Lophiolepis), is definitively not monophyletic.
Reply to Del Guacchio et al. The Genus Lophiolepis Is at Least as Well Supported as Afrocarduus, Afrocirsium, and Nuriaea. Comment on “Moreyra et al. African Mountain Thistles: Three New Genera in the Carduus-Cirsium Group. Plants 2023, 12, 3083”
Authors: Moreyra Lucía D. , Susanna Alfonso
Published: December 2024

We recently published a paper that presented the first Hyb-Seq phylogeny for subtribe Carduinae, in which we described three new genera endemic to the African Sky-Islands [...]
Research on Lettuce Canopy Image Processing Method Based on Hyperspectral Imaging Technology
Authors: Chen Chao , Jiang Yue , Zhu Xiaoqing
Published: December 2024

For accurate segmentation of lettuce canopy images, dealing with uneven illumination and background interference, hyperspectral imaging technology was applied to capture images of lettuce from the rosette to nodule stages. The spectral ratio method was used to select the characteristic wavelengths, and the characteristic wavelength images were denoised and image fused before being processed by filtering and threshold segmentation. To verify the accuracy of this segmentation method, the manual segmentation method and the segmentation method used in this study were compared, and the area overlap degree (AOM) and misclassification rate (ME) were used as criteria to evaluate the segmentation results. The results showed that the segmentation effect was the best when 553.8 nm, 702.5 nm and 731.3 nm were selected as the characteristic wavelengths of lettuce for the spectral ratio method, with an AOM of 0.9526 and an ME of 0.0477. Both have a variance of less than 0.01 and have the best stability. Hyperspectral imaging technology combined with multi-wavelength image and multi-threshold segmentation can achieve accurate segmentation of lettuce canopy images.
Ammonium Polyphosphate Promotes Maize Growth and Phosphorus Uptake by Altering Root Properties
Authors: Dong Siqi , Bismark Asante-Badu , Li Songsong , Gao Qiang , Zhou Xue , Li Cuilan
Published: December 2024

Phosphorus (P) is an essential nutrient for maize growth, significantly affecting both yield and quality. Despite the typically high concentration of available P in black soils, the efficiency of crop uptake and utilization remains relatively low. This study aimed to evaluate the effects of different P fertilizers on maize yield, root growth parameters, and P use efficiency to identify strategies for optimizing P management in black soil regions. Field experiment results indicated that the combination of ammonium polyphosphate (APP) with other P fertilizers led to variations in yield and P fertilizer absorption efficiency. Various P fertilizers were tested, including diammonium phosphate (DAP), ammonium polyphosphate (APP), fused calcium magnesium phosphate (FCMP), a combination of DAP and FCMP (DAP+FCMP), and a control with no phosphate (CK). The results indicated that P application significantly increased maize yield, with APP (171.8 g/plant) outperforming other P application treatments. Different P fertilizer types significantly affect soil P content and the composition of P fractions. APP significantly increased both the total P (TP) and the proportion of inorganic P (Pi). Furthermore, APP application significantly improved root length (RL), surface area (SAR), and root activity (RA) compared to CK, leading to enhanced nutrient absorption. APP also significantly increased P uptake and utilization (REp, FPp, AEp, PHI, and PAC). In summary, by optimizing plant biomass and P uptake, APP can directly and indirectly influence maize yield. Improving rhizosphere properties through the selection of suitable fertilizer types can enhance fertilizer use efficiency and increase maize production.
Supercritical CO2 Extraction vs. Hexane Extraction and Cold Pressing: Comparative Analysis of Seed Oils from Six Plant Species
Authors: Schoss Katja , Glavač Nina Kočevar
Published: December 2024

Supercritical fluid extraction using carbon dioxide (SFE-CO2) brings a convincing advance in the production of plant oils used in cosmetics, in fortified foods and dietary supplements, and in pharmaceuticals and medicine. The SFE-CO2-extracted, hexane-extracted, and cold-pressed plant oils of pumpkin (Cucurbita pepo L.), flax (Linum usitatissimum L.), linden (Tilia sp.), poppy (Papaver somniferum L.), apricot (Prunus armeniaca L.), and marigold (Calendula officinalis L.) seeds were investigated in terms of oil yield, fatty acid composition, unsaponifiable matter yield and composition, and the antioxidant activity of unsaponifiable matter. SFE-CO2 proved to be the preferred extraction method for four out of six plant materials, especially for seeds with lower oil content. However, for seeds with higher oil content, such as apricots, cold pressing is a viable alternative. A comparison of fatty acid composition did not reveal significant differences between extraction techniques. SFE-CO2 extraction improved the total phytosterol content of oils, especially pumpkin seed oil. A high variability in the antioxidant potential of the unsaponifiable matter studied was determined, with pumpkin seed oil showing the highest antioxidant activity. A correlation analysis was performed between unsaponifiable composition and antioxidant activity, and showed statistically significant correlations with squalene, cycloartenol, and an unidentified compound. This is the first comparison of the phytosterol compositions of linseed, apricot, linden, and marigold. Through continued optimization, SFE-CO2 has the potential to revolutionize the production of plant oils and provide a sustainable and efficient alternative.
Insights into the Heat Shock Protein 70 (Hsp70) Family in Camelina sativa and Its Roles in Response to Salt Stress
Authors: Heidari Parviz , Rezaee Sadra , Hosseini Pouya Hadiseh Sadat , Mora-Poblete Freddy
Published: December 2024

Hsp70s, a group of heat shock proteins, are ancient proteins that play a crucial part in maintaining the stability of cells when faced with various internal and external stresses. In this research, there are 72 CsHSP70 genes present and verified in Camelina sativa, all of which exhibit a wide range of physicochemical characteristics. Through evolutionary analysis, the Hsp70 family was categorized into five primary groups, and numerous segmental duplications were anticipated among the CsHSP70 genes. The GO enrichment analysis of co-expression network elements revealed a significant association between key signaling terms, such as phosphorelay signal transduction, and MAPK cascade with the function of CsHsp70. An analysis of transcriptome data exposed to cold, drought, salinity, and cadmium stress demonstrated the varied expression profiles of CsHsp70 genes. The expression levels of CsHSP70 genes varied across various organs and stages of development in camelina, although some of them illustrated tissue-specific expression. qRT-PCR analysis further disclosed that CsHsp70-60, -52, and -13 were up-regulated and CsHsp70-03, -58, and -09 showed down-regulation in response to salinity. Furthermore, CsHsp70 genes are categorized as late-responsive elements to salinity stress. Through docking analysis, the current research revealed that CsHsp70 proteins interacted with ABA, BR, and MeJA.
Traditionally Used Medicinal Plants of Armenia
Authors: Ayvazyan Arpine , Zidorn Christian
Published: December 2024

The rich and diverse flora of Armenia has been used for medicinal purposes for at least 3000 years. The relevant literature in Armenian, English, and Russian revealed a vast array of used medicinal plants, some of them unique to the Caucasus region. The usage of medicinal plants confirms the position of Armenia as a country at the crossroads of Asia and Europe because of its traditional usage of medicinal plants from both continents. Literature data in Armenian, English, and Russian on medicinal plants of Armenia were mainly obtained using various electronic databases. From all available sources, 320 Armenian medicinal plant species were extracted with their botanical and local names and traditional uses. The use of medicinal plants by the Armenian people is systematically compiled, including the used plant organs and preparations and the ailments for which the various taxa are/were used. Medicinal plants of Armenia are represented for both wild and cultivated species. Some of the taxa used are unique to Armenia or the Caucasus region, while many other species are also used in various other countries. Some of the species from traditional Armenian medicine are currently being studied using modern methods.
Evaluating Processing Parameter Effects on Polymer Grades and Plastic Coloring: Insights from Experimental Design and Characterization Studies
Authors: Alsadi Jamal , Alawneh Ameen , Khatatbeh Ahmed Ali , Abdel Wahed Mutaz , Alseafan Mustafa , Alomari Saleh
Published: December 2024

Resolving material and processing issues is essential to improving formulations and attaining accurate color matching in blending. Two transparent polycarbonate resins made up the blend: PC1, which made up 33% of the mixture with a Melt Flow Index (MFI) of 25 g/min, and PC2, which made up 67% of the mixture with an MFI of 65 g/min. This study employed data mining and a well-structured experiment using Design of Experiment (DoE) software-8 to investigate the effects of various processing temperatures on identical material formulations. The primary objective was to understand the influence of the operating conditions on the viscosity of a red letdown pigment made of polycarbonate, both with additive (WA) and without additive (WOA). The study analyzed the effects of processing parameters and rheological properties using a co-rotating twin-screw extruder. Rheology, Fourier-Transform Infrared Spectroscopy (FTIR), and Scanning Electron Microscopy (SEM) were employed to compare results and evaluate their impact on minimizing color discrepancies and improving Single-Pass Color Uniformity.
Improving the Elastic Response of Tanned Leather by Treatment with a Carboxylic Elastomer
Authors: Marinai Daniele , Borchi Cristiana , Marinai Lorenzo , Defeo Gustavo Adrián , Manariti Antonella , Minei Pierpaolo , Castelvetro Valter , Ciardelli Francesco
Published: December 2024

The elastic response of chromium-tanned leather was successfully improved by treatment with XSBR, a carboxylated styrene-butadiene copolymer. The carboxylic groups pending from a styrene-butadiene rubber (SBR) backbone were found to promote penetration of the aqueous polymer dispersion into the fibrous tanned leather and participated in pH-reversible physical crosslinking by H-bonding. The different penetrations of XSBR or SBR were investigated using a micro-FTIR cross-sectional analysis from the grain (outer) to the flesh (inner) side of 18 wt% elastomer-treated samples, based on the shaved leather weight. In particular, the profile of the diagnostic out-of-plane =C-H bending of butadiene and styrene units was consistent with a more effective penetration of XSBR. The leather with XSBR showed a comparatively lower elastic modulus of 10–15% and roughly a 10% increase in elongation at the break, indicating better flexibility and shape recovery. Also, the leather was characterized by a 15% higher burst strength. These results suggest the better swelling of the ionomeric XSBR in the initial stage of retanning performed at a pH higher than the isoelectric point of the leather when both the tanned leather and the XSBR ionomer had a negative surface charge. The high pH favored the penetration of XSBR due to a poor attractive interaction with the tanned fibrous leather network. Subsequent processing in an acid bath caused further physical crosslinking through hydrogen bonding between XSBR and the leather.
Transient Viscosity Adjustment Using a Coaxial Nozzle for Electrospinning Nanofibers from Non-Spinnable Pure m-Poly(hydroxyamide)
Authors: Kim Yerim , Lim Jihwan , Kim Han Seong , Lee Jaejun , Chun Youngsang , Cho Dong-Hyun , Kang Chan Sol , Choi Sejin
Published: December 2024

In this study, a transient viscosity adjustment method using a coaxial nozzle was explored to fabricate nanofibers from non-spinnable m-poly(hydroxyamide) (m-PHA). Unlike conventional electrospinning methods that often require additives to induce fiber formation, this approach relies on a sheath-core configuration, introducing tetrahydrofuran (THF) to the sheath to temporarily adjust solution viscosity. The diffusion of THF into the core m-PHA solution resulted in momentary solidification at the interface, promoting nanofiber formation without compromising polymer solubility. SEM and rheological analyses confirmed that optimized sheath-to-core flow ratios yielded nanofibers with significantly reduced particle formation. Notably, increasing the THF flow rate facilitated a faster solidification rate, enhancing jet elongation and resulting in uniform nanofibers with diameters of approximately 180–190 nm. Although complete nanofibers without beads were not achieved in this study, this coaxial electrospinning approach presents a possible pathway for fabricating nanofibers from polymers with limited spinnability, potentially expanding the application scope of electro-spun materials in high-performance fields.
Upcycling Fishing Net Waste and Metal Oxide from Electroplating Waste into Alga Cultivation Structures with Antibacterial Properties
Authors: Barros Daniel , Nobre Luís , Antunes Joana , Bessa João , Cunha Fernando , Mota Carlos , Gomes Fernanda , Henriques Mariana , Fangueiro Raul
Published: December 2024

Plastic waste, especially discarded fishing nets, and electroplating sludges pose significant environmental challenges, impacting marine ecosystems and contributing to pollution. In alga cultivation, invasive microorganisms often hinder growth, necessitating strategies to combat these issues. This study aimed to develop recycled substrates for alga cultivation by repurposing fishing nets and enhancing their surfaces with antibacterial properties using copper oxide (CuO). Additionally, it explores the reuse of CuO from electroplating sludge, providing a sustainable solution that addresses both marine and industrial waste while supporting healthy alga development. Recycled substrates were produced, with different proportions of pure CuO and sludge (1 and 2 wt%) incorporated on the surface. These compositions were processed by hot compression molding and then the antibacterial activity was characterized using a qualitative and quantitative method. The results indicate the possibility of recycling fishing net into new substrates to alga cultivation and the functionalization of their surface using CuO as an antibacterial agent. The antibacterial tests showed a better activity for pure CuO compared to the residual sludge, and better for the higher surface concentration of 2 wt%. Despite the limited bacterial inhibition observed, there is an opportunity for reusing these sludges, typically disposed of in landfills, to obtain specific antibacterial agents that can be applied to the surface of substrates for algal growth.
Improved Algorithms Based on Trust Region Framework for Solving Unconstrained Derivative Free Optimization Problems
Authors: Liu Yongxia , Xu Te
Published: December 2024

This paper is devoted to developing new derivative-free optimization (DFO) methods for solving optimization problems where derivative information is not available or cannot be calculated numerically. To overcome the computational difficulties arising from time-consuming estimations of the objective function, we propose two algorithms. One algorithm is a variant of the surrogate model-based DFO algorithm under the trust region method, where the surrogate model is formulated through sparse low-rank interpolation and quadratic polynomial interpolation. This algorithm serves as a comparative baseline. The second algorithm leverages the characteristics of the sparse regression model, which can handle sparsity and noise issues, to construct the surrogate model. The coefficients of the sparse surrogate model are then estimated using the alternating direction method of multipliers and refined through a correction strategy based on the R-square. Finally, numerical results, evaluated in terms of performance and data profiles, demonstrate the effectiveness and competitiveness of the proposed algorithms.
Fruit Extracts Incorporated into Meat Products as Natural Antioxidants, Preservatives, and Colorants
Authors: Orădan Adrian Cristian , Tocai (Moțoc) Alexandra Cristina , Rosan Cristina Adriana , Vicas Simona Ioana
Published: December 2024

Nowadays, natural antioxidants, especially those found in fruits, are preferred over synthetic ones when used in a variety of meat products. Natural alternatives are preferred by consumers because synthetic additives in meat products have been connected to allergic reactions and other health-related problems. Fruits are abundant in phenolic compounds, providing them with particularly powerful antioxidants. Lipid oxidation is inhibited, allowing meat products to have an extended shelf life when enriched with fruit-derived components. The present study explores the potential of bioactive compounds derived from fruits, specifically phenolics, to improve the quality of meat products by virtue of their antimicrobial, antioxidant, and color-stabilizing qualities. In this review, the effects of 18 fruits on oxidative stability, antimicrobial activity, and color enhancement in meat products were investigated. The first section of this paper focuses on a presentation of the phytochemical composition and overall biological characteristics of the fruits. The thiobarbituric acid test, the peroxide value, and oxidative protein changes were used to assess oxidative stability. By scavenging free radicals or chelating metals, the phenolic compounds not only prevent lipid peroxidation but also protect myoglobin from oxidation, thereby improving the color of meat substitutes. Phenolic compounds provide antimicrobial actions by compromising bacterial cell walls, disrupting membrane integrity, or inhibiting essential enzymes necessary for microbial growth. Fruit extracts have shown effectiveness against foodborne pathogens and spoiling bacteria. Adding fruits to meat products is a promising way to improve their nutritional profile, sustainability, and quality. In order to guarantee consumer safety, future studies must concentrate on thorough toxicological analyses of fruit extracts meant to be used in food.
Enhancement of Anti-UV Aging Performance of Asphalt Modified by UV-531/Pigment Violet Composite Light Stabilizers
Authors: Zhang Fa , Liu Yang , Cao Zhenhao , Liu Yifan , Ren Yufang , Liang Haishan , Wang Kunyu , Zhang Yanyan , Wang Jia , Li Xue
Published: December 2024

Ultraviolet (UV) radiation accelerates the aging of asphalt pavements and shortens the service life of the pavement. To effectively mitigate the impact of UV aging on asphalt performance, a novel composite anti-UV aging agent, 2-hydroxy-4-n-octyoxybenzophenone/pigment violet (UV-531/PV), was developed. After UV-accelerated aging, the modified asphalt samples were characterized by conventional performance tests, Fourier transform infrared spectroscopy (FTIR), gel permeation chromatography (GPC), and a dynamic shear rheometer (DSR). The results show that UV-531/PV-composite-modified asphalt maintains excellent conventional properties after UV aging. The FTIR testing showed that the changes in carbonyl index (Ic=o) and sulfoxide index (Is=o) of the composite-modified asphalt were significantly smaller than those of the matrix asphalt, indicating the less oxidation degree of the composite-modified asphalt. The GPC test results showed that the change in molecular weight of the composite-modified asphalt after UV aging was less than that of the matrix asphalt. DSR results showed that UV-531/PV-modified asphalt exhibited higher viscoelasticity and higher rutting resistance than unmodified asphalt. This study proposes a new method for preparing anti-UV aging asphalt, which can be used for micro-surfacing, fog sealing or ultra-thin overlay on road surfaces.
Spinnability and Morphological Stability of Carboxymethyl Cellulose and Poly(Vinyl Alcohol) Blends by Electrospinning
Authors: Anaya-Mancipe Javier M. , da Silva Vanessa F. , Becerra-Lovera Angela Y. , Dias Marcos L. , Thiré Rossana M. S. M.
Published: December 2024

Carboxymethyl cellulose (CMC) is a plant-derived polymer known for its excellent anti-adhesive properties, making it suitable for dressings for highly exudative lesions. However, CMC alone is considered an un-spinnable biopolymer due to its complex intermolecular interactions. This study explored the spinnability of CMC through electrospinning by blending it with poly(vinyl alcohol) (PVA) at an 8:2 (PVA/CMC) ratio. Two types of PVA with varying molecular weights and degrees of hydrolysis were used at different concentrations. Solutions were prepared with Milli-Q water at 90 °C for about 2 h, followed by electrospinning under different voltages and flow rates. Scanning electron microscopy (SEM) was used to assess spinning ability, while Fourier-transform infrared spectroscopy (FTIR-ATR) characterized the mats’ chemical composition. Thermal behavior was analyzed using thermogravimetry analysis (TGA) and differential scanning calorimetry (DSC). Results showed that the neat PVA.1 solution produced smaller nanofibers (~217.9 nm), while the PVA.1/CMC blend resulted in a smaller fiber diameter (129.9 nm) but with more defects due to higher surface tension. In contrast, PVA.2 and PVA.2/CMC exhibited larger diameters (448.6 nm and 270.1 nm, respectively) and better thermal and morphological stability, indicating their potential for anti-adhesive chronic wound dressings.
Remarks on the Study of the Electronic Properties and Photoionization Process in Rotating 2D Quantum Rings
Authors: Pereira Carlos Magno O. , Azevedo Frankbelson dos S. , Silva Edilberto O.
Published: December 2024

The electronic and optical properties of a mesoscopic heterostructure of a two-dimensional quantum ring composed of Gallium Arsenide (GaAs) semiconductors are investigated. Using the confinement potential proposed by Tan and Inkson to describe the system under analysis, we conducted a numerical study of the photoionization cross-section for a 2D quantum ring with and without rotation effects. The interior of the quantum ring is traversed by an Aharonov–Bohm (AB) flux. Our research aims to investigate how this mesoscopic structure’s electronic and optical properties respond to variations in the following parameters: average radius, AB flux, angular velocity, and incident photon energy. Under these conditions, we establish that optical transitions occur from the ground state to the next excited state in the conduction subband, following a specific selection rule. One of the fundamental objectives of this study is to analyze how these rules can influence the general properties of two-dimensional quantum rings. To clarify the influence of rotation on the photoionization process within the system, we offer findings that illuminate the effects of the pertinent physical parameters within the described model. We emphasize that, although this is a review, it provides critical commentary, analysis, and new perspectives on existing research. Some results presented in this paper can be compared with those in the literature; however, new physical parameters and quantum ring configurations are used.
Predicting Tumor Progression in Patients with Cervical Cancer Using Computer Tomography Radiomic Features
Authors: Prasla Shopnil , Moore-Palhares Daniel , Dicenzo Daniel , Osapoetra LaurentiusOscar , Dasgupta Archya , Leung Eric , Barnes Elizabeth , Hwang Alexander , Taggar Amandeep S. , Czarnota Gregory Jan
Published: December 2024

The objective of this study was to evaluate the effectiveness of utilizing radiomic features from radiation planning computed tomography (CT) scans in predicting tumor progression among patients with cervical cancers. A retrospective analysis was conducted on individuals who underwent radiotherapy for cervical cancer between 2015 and 2020, utilizing an institutional database. Radiomic features, encompassing first-order statistical, morphological, Gray-Level Co-Occurrence Matrix (GLCM), Gray-Level Run Length Matrix (GLRLM), and Gray-Level Dependence Matrix (GLDM) features, were extracted from the primary cervical tumor on the CT scans. The study encompassed 112 CT scans from patients with varying stages of cervical cancer ((FIGO Staging of Cervical Cancer 2018): 24% at stage I, 47% at stage II, 21% at stage III, and 10% at stage IV). Of these, 31% (n = 35/112) exhibited tumor progression. Univariate feature analysis identified three morphological features that displayed statistically significant differences (p < 0.05) between patients with and without progression. Combining these features enabled a classification model to be developed with a mean sensitivity, specificity, accuracy, and AUC of 76.1% (CI 1.5%), 70.4% (CI 4.1%), 73.6% (CI 2.1%), and 0.794 (CI 0.029), respectively, employing nested ten-fold cross-validation. This research highlights the potential of CT radiomic models in predicting post-radiotherapy tumor progression, offering a promising approach for tailoring personalized treatment decisions in cervical cancer.