bluuebunny/crossref_metadata_2025 huggingface dataset:
Emotion vs conflict-generating communication in a hybrid media environment
Authors: Stepanov Valentin N.
Published: March 2024

The research is devoted to the phenomenon of emotional and conflict-generating communication. Pragmatic information was chosen as the object of study, which is based on the intention of implication, the hidden intention of the addresser. The subject of the study is special, provocative speech genres, regarded as tools for presenting pragmatic information, their system and typology. Provocative discourse is considered in the work as a special type of intentional discourse, and provoking is understood as the infection of the interlocutor with the real or imaginary (skillfully imitated) intentional state of the speaker. Provoking, therefore, is a typical example of emotional contagion, emotiogenicity. The material for the analysis was mass communication texts; the body of the study consisted of the headlines of direct mail advertising texts. Two basic provocative genre strategies - confession and concern - are identified, each of which includes, as identifiable elements, the (elementary) provocative genres of confession, presentation, maxim, demonstrative, complaint, advice, notation, reproach, provocative question, propheseme.
THE CONTESTATION OF CANING AND IMPRISONMENT FOR SEXUAL HARASSMENT: TRACING THE ROOTS OF JUDGES’ LEGAL CONSIDERATIONS IN ACEH, INDONESIA
Authors: Salam Abdul Jalil , Abubakar Ali , Makinara Ihdi Karim
Published: March 2024

Qanun Jinayat or the Islamic Criminal Code in Aceh responds to sexual violence by stipulating norms for caning, imprisonment, and fines for offenders of these types of crimes. This is a positive effort in combating sexual crime which has become a global problem. However, at the technical level, especially in court, the ideals of justice for victims, offenders, and the community, are "disturbed" by the emergence of normative contestations between caning and imprisonment. This paper, thus, dissects the reality of the contestation referred to the judge’s decision in the Court of Appeals, the factors that influence the judge’s verdict and its implications for the protection of victims. Primary data is the decisions of the Mahkamah Shar`iyah (Religious Court) at the first level, appeals and cassation for 2016-2020, while secondary data is in the Qanun Jinayat and other Aceh local qanuns. The data is tabulated in such a way as to find the dominant form of punishment, including all offenses regulated by the Qanun Jinayat and forms of caning and imprisonment which are continued at the Court of Appeal to find possible changes in the form of punishment from the Court of First Instance. Data were analyzed using the concepts of norm contestation, judges' legal considerations, and legal protection for victims of sexual violence. The findings revealed that the contestation occurred due to legal, extra legal and regulatory dualism scenarios. This has further triggered latent contestation of authority. As a result, victims of sexual violence crimes, especially children, have not received proper protection. Hence, further studies and specific stakeholder policies are needed.
Application of In Vivo Reflectance Confocal Microscopy in the Diagnosis of Bowen's Disease
Authors: Ding Shu , Hu Lingxue , Rao Yu , Ren Ruijian , Tong Xiaoliang , Guo Aiyuan , Huang Jian , Tang Zhen
Published: March 2024

Bowen’s disease (BD) is a relatively rare early-stage squamous cell
carcinoma in situ, most commonly affecting the middle-aged and elderly,
and occurring on the skin or mucous membranes of various parts of the
body. Its onset is concealed, the course of the disease is chronic, and
some patients are accompanied by malignant tumors outside the skin, so
it is necessary to diagnose and evaluate the disease in its early stage.
This study aims to investigate the application of reflectance confocal
microscopy (RCM) in diagnosing Bowen’s disease. We performed RCM imaging
on the lesion site of 113 patients initially diagnosed with Bowen’s
disease in clinic, of which 92 patients underwent skin biopsy for
histological diagnosis. A retrospective analysis of the RCM result as
well as the histological examination revealed that after analyzing RCM
images, 69 out of 113 patients were diagnosed with Bowen’s disease; out
of 92 biopsy lesions, 61 were Bowen’s disease, of which 54 were
consistent with RCM diagnosis. Among 59 cases diagnosed with Bowen’s
disease by RCM, 54 cases were consistent with histological diagnosis.
Afterwards, we analyzed the RCM characteristics in patients with Bowen’s
disease verified by biopsy, and compared the RCM images of two different
lesions, Classic Bowen’s Disease (CBD) and Pigmented Bowen’s Disease
(PBD), and further summarized the key points of Bowen’s disease under
RCM. Finally, we focused on the differential characteristics between
Bowen’s disease and other skin diseases under RCM. It is found that RCM
is of great value in diagnosing Bowen’s disease.
Chaos and Mixing in NETmix
Authors: Matos Joana , Santos Ricardo , Dias Madalena , Lopes José Carlos
Published: March 2024

NETmix is a network of mixing chambers interconnected by channels, in
which the most efficient mixing occurs under chaotic flow regimes. Chaos
is highly influenced by the topology, particularly by the ratio chamber
diameter/channel width, D/d. In this work, micromixing in NETmix is
characterized through Lagrangian Mixing Simulation (LMS), which enables
to establish the relation between the degree of mixing and the topology,
D/d. The degree of mixing is then related with the Eulerian chaoticity
from hydrodynamics and spectral analysis. The best mixing is obtained at
D/d = 6.65 and is associated to a thin 8 shaped strange attractor. The
spectral analysis shows a principal oscillation frequency at St = 0.13.
Since the quasi-periodic regime is alternated with chaotic behaviour,
NETmix has an intermittent bifurcation. For the NETmix system, orderly
flows in the quasi-periodic regime have higher mixing intensity than
less orderly flows in the weak or strong chaotic regimes.
Integrating land resilience assessment to revisit the sustainable land degradation neutrality target of China
Authors: Zhang Chenwei , Wu Si , Hu Hongwei , Hu Shougeng
Published: March 2024

Improving land degradation neutrality (LDN) assessment is essential to
address land degradation. Although land resilience contributes to the
achievements of sustainable LDN targets, its specific assessment program
is sparsely considered in LDN to date. In our research, we constructed a
new LDN assessment system for China and tried to provide a concrete
practical solution for sustainable land use. Results have indicated that
there were only 1.11×10 km
(11.07%) of highly resilient land in China. The spatial distribution
pattern of ‘western recovery-central balance-eastern degradation’ have
been developed in the past 20 years. The reduction of areas and
imbalance of spatial distribution have put pressures on sustainable LDN
targets. Land productivity of major grain producing regions have risen
enormously with significant degradation in land resilience. We
recommended prioritizing the restoration of land resilience in major
grain producing areas and cooperating LDN with other sustainable
development goals at the watershed scales. Furthermore, this study not
only provided an effective and convenient tool for sustainable LDN
assessment, but also contributed to the LDN governance and actions to
curb land degradation around the world.
Some spectral norms of RFPrLrR circulant matrices
Authors: Shi Baijuan , Kızılateş Can
Published: March 2024

In this article, based on combinatorial methods, the structure of RFPrLrR
circulant matrices and the identities of matrix norms, we give three lower
bounds and upper bounds for spectral norms of RFPrLrR circulant matrices
involving exponential forms and trigonometric functions by using a different
method. Moreover, we introduce new geometric RFPrLrR circulant matrix, and
then we obtain three lower bounds for spectral norms and its upper bound.
Pointwise semi-slant Riemannian (PSSR) maps from almost Hermitian manifolds
Authors: Gündüzalp Yılmaz , Akyol Mehmet
Published: March 2024

In this paper, as a generalization of pointwise slant submanifolds [B-Y. Chen
and O. J. Garay, Pointwise slant submanifolds in almost Hermitian manifolds,
Turk J Math 36, (2012), 630-640.], pointwise slant submersions [J.W.Lee and
B.S. ahin, Pointwise slant submersions, Bulletin of the Korean Mathematical
Sosiety, 51(4), (2014), 115-1126.] and pointwise slant Riemannian maps [Y.
G?nd?zalp and M. A. Akyol, Pointwise slant Riemannian maps from Kaehler
manifolds, Journal of Geometry and Physics, 179, (2002), 104589.], we
introduce pointwise semi-slant Riemannian maps (briefly, PSSR maps) from
almost Hermitian manifolds to Riemannian manifolds, present examples and
characterizations. We also investigate the harmonicity of such maps.
Moreover, we give Chen-Ricci inequality for a PSSR map. Finally, we study
some curvature relations in complex space forms, involving Casorati
curvatures for PSSR maps.
A parameter-uniform weak Galerkin finite element method for a coupled system of singularly perturbed reaction-diffusion equations
Authors: Toprakseven Şuayip , Zhu Peng
Published: March 2024

The aim of this paper to investigate a weak Galerkin finite element method
(WG-FEM) for solving a system of coupled singularly perturbed
reaction-diffusion equations. Each equation in the system has perturbation
parameter of different magnitude and thus, the solutions will exhibit two
distinct but overlapping boundary layers near each boundary of the domain.
The proposed method is applied to the coupled system on Shishkin mesh to
solve the problem theoretically and numerically. Elimination of the interior
unknowns efficiently from the discrete solution system reduces the degrees
of freedom and, thus the number of unknown in the discrete solution is
comparable with the standard finite element scheme. The stability and error
analysis of the proposed method on the Shishkin mesh are presented. We show
that the method convergences of order O(N?k lnk N) in the energy norm,
uniformly with respect to the perturbation parameter. Moreover, the optimal
convergence rate of O(N?(k+1)) in the L2-norm and the superconvergence rate
of O((N?2k ln2k N) in the discrete L?-norm is observed numerically. Finally,
some numerical experiments are carried out to verify numerically theory.
Inhibition of HSP20 ameliorates steatotic liver disease by stimulating ERK2-dependent autophagy
Authors: Miao Yanli , Zhong Yi , Li Yutian , Qin Haojie , Yang Ling , Cao Guojun , Tang Yong , Yu Ting , Fan Di , Lu1 Yang , Peng Jiangtong , Huang Kai
Published: March 2024

Heat shock protein 20 (HSP20) emerges as a novel regulator of autophagy in the heart. Nonetheless, the detailed function of HSP20 in liver and its effect on autophagy remain unknown. Here, we observed that HSP20 expression is increased in liver tissues from mice and patients with metabolic dysfunction-associated steatotic liver disease (MASLD), formerly known as nonalcoholic fatty liver disease (NAFLD). Liver-specific downregulation of HSP20 mitigates hepatic steatosis and insulin resistance in obese mice, while upregulating HSP20 promotes lipid deposition and hepatocyte cell death. Mechanistically, Liquid chromatography tandem mass spectrometry (LC-MS/MS) revealed that HSP20 interacts with phosphorylated extracellular regulated protein kinases 2 (ERK2) and prevents its dephosphorylation by dual specificity phosphatase 6 (DUSP6), leading to ERK2-mediated repression of autophagy, resulting in aggravated saturated fatty acid (SFA)-triggered hepatocyte death. Importantly, such adverse effects could be ameliorated by ERK inhibitor. Our data reveals a framework of how HSP20 increases susceptibility of SFA-induced liver injury through enhancing ERK2 phosphorylation, which represents a plausible therapeutic intervention to combat MASLD.
ASSISTANCE OF STUDENT LITERACY ACTIVITIES OF UIN K.H. ABDURRAHMAN WAHID FOR EXTRAORDINARY STUDENTS AT SLB PRI PEKALONGAN
Authors: Chonitsa Ana , Amma Chorida Adila  , Hendri Hermawan Adinugraha
Published: March 2024

The development of the times and technology has had an impact on the personality and self-esteem of today's youth, such as the loss of social sense and concern for others in society. Therefore, there is literacy assistance for FTIK UIN K.H Abdurrahman Wahid Pekalongan students which aims to foster student awareness in the community, especially education in Special Schools with students with special needs. This community service method includes four stages, namely activity introduction, creativity education, rewarding, and activity documentation. The results of community service show that this activity produces social learning and increases student creativity in creating learning that is appropriate to the situations and conditions of students with special needs. Student creativity created in learning models includes singing learning models, image visualization, origami loving, telling stories, coloring pictures, storytelling, and playing guessing games. Thus, students not only gain new experiences but also ideas and creativity to increase sensitivity in the social environment of society
ENTREPRENEURSHIP TRAINING FOR STUDENTS AT RAUDHATUNNASYIIN BOARDING SCHOOL, BANJARBARU
Authors: Rusdiana Rusdiana
Published: March 2024

Article (PKM) is motivated by the existence of the Raudhatul Muhibbin Islamic Boarding School Foundation which aims to provide a concrete understanding of the concept of entrepreneurship so that the students of the Raudhatul Muhibbin Islamic Boarding School Foundation can develop their economy better.
The method used in this PKM article is a field study by directly giving directions to the students of the Raudhatul Muhibbin Islamic Boarding School Foundation while the source of data is through observation, interviews and documentation.
The results of this PKM are, first, the students of the Raudhatul Muhibbin Islamic Boarding School Foundation understand more about the concept of entrepreneurship that is in accordance with Islam. Second, the students of the Raudhatul Muhibbin Islamic Boarding School Foundation can practice entrepreneurial strategies according to Islamic concepts
A prospective study of financial worry, mental health changes and the moderating effect of social support among Canadian adolescents during the COVID-19 pandemic
Authors: Goddard Jessica A. , Pagnotta Valerie F. , Duncan Markus J. , Sudiyono Matthew , Pickett William , Leatherdale Scott T. , Patte Karen A.
Published: March 2024

Introduction

The COVID-19 pandemic intensified the impact of risk factors for adolescent mental health, including financial worry. Social support has shown to protect from negative mental health during times of stress. We examined the effect of financial worry on changes in anxiety and depression symptoms among Canadian adolescents prior to and during the pandemic, and assessed whether social support from family and friends moderated any changes.

Methods

We analyzed 2-year linked data from the 2018/19 (pre-pandemic) and 2020/21 (during-pandemic) waves of the COMPASS study, with reports from 12 995 Canadian secondary school students. A series of multilevel linear regressions were conducted to examine the main hypotheses under study.

Results

Students scored an average (SD) of 7.2 (5.8) on the anxiety (GAD-7) and 10.0 (6.5) on the depression (CESD-10) scales; 16.1% reported they experienced financial worry during the pandemic. Financial worry was a strong and significant predictor of increased anxiety scores (+1.7 score between those reporting “true/mostly true” versus “false/mostly false”) during the pandemic, but not for depression scores. Low family and friend support were associated with anxiety, and low family support was associated with depression. No significant interactions were detected between social support and financial worry.

Conclusion

Pandemic-related financial worry was significantly associated with anxiety in our large sample of Canadian adolescents. Clinical and public health initiatives should be aware of adolescents’ financial worry and its associations with anxiety during times of crisis.
The Perceived Role of Non-Elected Actors in Community Power Structure
in Poland: Results of a Survey Experiment
Authors:   Professor, Institute of Spatial Management, Faculty
of Spatial Management and Landscape Architecture,
Wrocław University of Environmental and Life Sciences, Wrocław, Poland, SWIANIEWICZ Paweł
Published: March 2024

Administrative decisions can be influenced not only by policies formulated by elected representatives but also by various external actors. From classic elitist and pluralist theories of community power to urban regime and network governance concepts, academic studies tell us that several institutional and individual actors with no electoral democratic legitimacy may have a significant impact on local government decision-making. In our paper, we ask the question who they are in contemporary Polish cities. Are there any systematic regularities in this respect concerning e.g. how they differ depending on the size of the local community? In this paper we look at the phenomenon through the lens of citizens’ perception of the influence on important administrative decisions made in local governments. In this research, we also check whether the style of local political leadership perceived by citizens is reflected in their expectations toward the propensity of local authorities to consider the opinions.
Data is collected through a survey conducted on a representative sample of 2,000 Polish citizens who were asked about their perception of the impact of various business and societal actors. The study uses the survey experiment method in which various formulations of the question are randomly assigned to individual respondents, which allows us to measure the perceived influence of individual types of actors. Referring to the recent debate on the limitation of the applicability of regime theory to large cities only, we place a special attention to the impact of city size on the role of big and small businesses as well as various societal organizations.
Exploring the factors influencing the decision to enrol in graduate school among the school-age population
Authors:   Korea Univ. Institute of Educational Research, Byoun Suyoun
Published: March 2024

This study explores the influence of college students' socioeconomic background, characteristics of their home university, undergraduate educational experiences, and interaction terms of the main variables on their decision to pursue the graduate degree. The sample was constructed by linking the results of the KELS(Korean Educational Longitudinal Survey) 9th four-year college student survey and the 10th to 12th graduate student survey (N=1,566). On this sample, cross-sectional analyses, independent group t-tests, and binary logistic regression analyses with graduate school enrolment as the dependent variable were conducted. The analysis shows that parents' willingness to pay for graduate education, graduation from a public university, high grades in major courses, major-aptitude match, home university location - governance type interaction term have statistically significant positive effects on the decision to go to graduate school. Additional binary logistic regression analyses were conducted on various student groups with different characteristics. Based on the results, the main variables are discussed and policy implications are presented.
A Qualitative Study on the Difficulties of Student Teachers in Health Education During Their Teaching Practicum
Authors:   Korea Univ. Institute of Educational Research, Yoon SeokJu
Published: March 2024

The purpose of this study was to explore the difficulties and challenges student teachers of health education in the process of their teaching practicum for one month. The author interviewed nine student teachers of health education in which they practicum in the middle school and high school. The main results were as follows: First, the prospective health education teachers felt gaps between what they learned in the university and teaching practice in their practicum schools; Second, the prospective health education teachers felt limitations in their role as student teachers, both in conducting lessons of health education and providing student guidance; Third, the participants faced challenges in reconciling different educational philosophies between teachers at their practicum schools and fellow prospective health education teachers; Last, while conducting classes at the practicum schools, the participants were engaged in ongoing reflection and inquiry into the issues that teachers inevitably dealt with. The findings suggested several implications to improve school practicum for the professional development of pre-service teachers of health education.
Tissue expression of porcine transient receptor potential mucolipin protein channels and their differential responses to porcine reproductive and respiratory syndrome virus infection in vitro
Authors: Xia Zhiqiang , Long Denggao , Hong Xinyi , Lan Ying , Xie Lixia
Published: March 2024

Introduction

Porcine reproductive and respiratory syndrome virus (PRRSV) infection results in a serious disease, posing a huge economic threat to the global swine industry. The transient receptor potential mucolipin proteins (TRPMLs) have been shown to be strongly associated with virus infection and other physiological processes in humans, but their tissue distribution and responses to PRRSV in pigs remain unknown.

Material and Methods

Quantitative reverse-transcription PCR analysis was undertaken to determine the optimal primer for TRPML expression detection and for quantifying that expression individually in different pig tissue samples. Meat Animal Research Center 145 (MARC-145) monkey kidney cells and the TRPML-specific activator mucolipin synthetic agonist 1 (ML-SA1) were used to reveal the relationship between TRPML and PRRSV-2 infection.

Results

The best primers for each TRPML gene used in a fluorescence-based quantitative method were identified and TRPML1 was found to be highly expressed in the kidneys and liver of pigs, while TRPML2 and TRPML3 were observed to be primarily expressed in the kidney and spleen tissues. The expression of TRPML2 was upregulated with the rise in PRRSV-2 infection titre but not the expression of TRPML1 or TRPML3, and ML-SA1 inhibited PRRSV-2 in a dose-dependent manner.

Conclusion

Our research revealed the gene expression of TRPMLs in pigs and identified that TRPML channels may act as key host factors against PRRSV infection, which could lead to new targets for the prevention and treatment of pig infectious diseases.
Prevalence of peptic ulcer among medical students in Saudi Arabia
Authors: Taha Medhat , Atyah Maryam , Almasary Manal , Bamahdi Hanin , Alharbi Lama
Published: March 2024

Objective: This study aimed to assess the prevalence of peptic ulcers among Saudi medical students and identify relevant risk factors for the condition.
Methods: This cross-sectional study was conducted from October to November 2023 using an online survey to measure the prevalence of peptic ulcers among the selected medical students in Saudi. A self-administered questionnaire was used to collect data on the medical students' demographics, stress faced during their studies, and peptic ulcer disease symptoms, risk factors, and preventive measures.
Results: The study covered 986 medical students from various regions of Saudi Arabia, excluding those who declined participation. Of the participants, 66.9% were females, 51.1% were aged 21-23 years, and 24.2% were studying in fourth year. In terms of peptic ulcer diagnoses, 86.1% had never been diagnosed, and 75.4% were unaware of family history. The most commonly reported symptom was abdominal pain (36.5%). In terms of stress, 30% experienced frequent academic-related stress, where most participants' coping mechanisms referred to socializing (44.4%) and considered examinations as their stressors (69%). Finally, the results also showed that 67.8% found preventing peptic ulcers very important, and 86.1% were interested in information on prevention. Among these, 61.4% preferred online resources.
Conclusion: The study revealed potential gender disparities in peptic ulcer prevalence. It highlighted the impact of advancing age and academic year on susceptibility to peptic ulcers and emphasized the need for preventive measures and stress management throughout medical education.
Post-thyroidectomy hypocalcemia in Saudi Arabia: a review of incidence rates and risk factors
Authors: Alameer Ehab
Published: March 2024

Post-thyroidectomy hypocalcemia is a frequent and variable complication in Saudi Arabia, which can extend hospital stays and raise healthcare costs. A systematic search was performed using databases for studies published before January 2024 documenting hypocalcemia rates in Saudi Arabian adults following thyroidectomy. Eighteen studies met our criteria, encompassing 3,455 patients. The analyses revealed substantial variability across included studies in terms of sample size, design, and reported hypocalcemia rates. Overall rates ranged from 0.07% to 67.4% (averaging 24.4%), with transient cases being more prevalent (averaging 26.8%). Permanent hypocalcemia rates were lower (averaging 1.3%, ranging from 0% to 3.7%). Preoperative and postoperative parathyroid hormone (PTH) levels consistently predicted hypocalcemia. Additional potential contributing factors included the number of parathyroid glands (PGs) identified during surgery, gender, pre-surgical hyperthyroidism, and surgical expertise and experience. These findings translate to several implications for surgical practice and patient management. Close monitoring of PTH levels holds significant importance. Selective identification of PGs during surgery might decrease the risk of hypoparathyroidism. In addition, surgeon training and supervision are pivotal for achieving optimal outcomes. Identifying patients at risk for hypocalcemia early might facilitate earlier discharge. In conclusion, post-thyroidectomy hypocalcemia poses a variable and widespread complication in Saudi Arabia. Comprehending its risk factors and implementing targeted strategies have the potential to improve patient management and outcomes.
Assessment of the impact of socio-economic indicators of the Volga Federal District of the Russian Federation on the number of payers of the Professional income tax
Authors: Kustov Nikita , Gorodilov Mikhail Anatol'evich
Published: March 2024

This article examines the impact of socio-economic indicators of the Volga Federal District (hereinafter – VFD) on the number of payers of the special tax - «Professional income tax (hereinafter – PIT)». The relevance of the article is due to the need to assess various socio-economic effects that cause an increase in the number of PIT payers in the regions of the Russian Federation. The purpose of this article is to identify these socio-economic indicators and then assess their impact on increasing the number of PIT payers in the region, which allows us to develop measures aimed at tax management in a particular region. Using econometric modeling methods, the authors assessed the impact on the number of PIT payers of such socio-economic indicators of the regions of the Volga Federal District as the number of individual entrepreneurs (hereinafter referred to as sole proprietors), GRP, the execution of regional budgets on PIT revenues, unemployment and nominal accrued wages. The materials used in the research process were obtained from open sources of official state statistics, consolidated tax and budget reports. The main results of this study are: - the indicator of the number of sole proprietors has a positive relationship with the number of PIT payers, which allows us to conclude that in regions with a larger number of individual entrepreneurs, the number of NPD payers is also growing; - the indicator of the number of unemployed has an inverse relationship with the number of PIT payers in the regions of the Russian Federation; Based on the results of an econometric study, the author concludes that a number of socio-economic indicators of the regions of the Volga Federal District have a significant impact on the number of PIT payers.
ddX: Polarizable Continuum Solvation from Small Molecules to Proteins
Authors: Nottoli Michele , Herbst Michael F. , Mikhalev Aleksandr , Jha Abhinav , Lipparini Filippo , Stamm Benjamin
Published: March 2024

Polarizable continuum solvation models are popular in both, quantum chemistry and in biophysics, though typically with different requirements for the numerical methods. However, the recent trend of multiscale modeling can be expected to blur field-specific differences. In this regard, numerical methods based on domain decomposition (dd) have been demonstrated to be sufficiently flexible to be applied all across these levels of theory while remaining systematically accurate and efficient. In this contribution, we present ddX, an open-source implementation of dd-methods for various solvation models, which features a uniform interface with classical as well as quantum descriptions of the solute, or any hybrid versions thereof. We explain the key concepts of the library design and its API, and demonstrate the use of ddX for integrating into standard chemistry packages. Numerical tests illustrate the performance of ddX and its interfaces.
Unveiling the Antioxidative Potential of Galangin: Complete and Detailed Mechanistic Insights through Density Functional Theory Studies
Authors: Spiegel Maciej
Published: March 2024

A comprehensive quantum mechanical investigation into the antioxidative activity of galangin (Glg) was conducted. Thermochemical and kinetic data were utilized to assess the antiradical, chelating, and renewal potential of all Glg species under physiological conditions. Initially, a brief comparison was made using the eH-DAMA method between reference antioxidants and other studied flavonoids characterising the substance as a moderate antioxidative agent. Also, Glg’s significantly lesser performance in lipid compared to aqueous solvent was noted. The reaction rates for scavenging •OOH in both media were established at 3.77 × 103 M-1 s-1 and 6.21 × 104 M-1 s-1, respectively, accounting for the molar fraction of both interacting molecules at the given pH. The impact of pH on the kinetics of the processes in water was also assessed. Although capable of efficiently chelating Cu(II) ions, the metal in such complexes can still easily undergo the Fenton reaction. However, the formed complexes persistently exhibit a capability to scavenge •OH in statu nascendi. Moreover, the flavonoid itself was found to effectively repair all oxidatively damaged biomolecules except model lipid acids. Since all Glg radical species were found to be readily restored by the physiologically prevailing O2•-, the polyphenol is expected to participate in antiradical and regenerating activities multiple times, amplifying its antioxidative potential.
Developing Differentiable Long-Range Force Field for Proteins with E(3) Neural Network Predicted Asymptotic Parameters
Authors: Cheng Zheng , Bi Hangrui , Liu Siyuan , Chen Junmin , Yu Kuang
Published: March 2024

Accurately describing long-range interactions is a significant challenge in molecular dynamics (MD) simulations of proteins. And high-quality long-range potential is also an important component of range-separated machine learning force field. This study introduces a comprehensive asymptotic parameter database, encompassing atomic multipole moments, polarizabilities, and dispersion coefficients. Leveraging active learning, our database comprehensively represents protein fragments with up to 8 heavy atoms, capturing their conformational diversity with merely 78,000 data points. Additionally, E(3) neural network (E3NN) is employed to predict the asymptotic parameters directly from the local geometry. The E3NN models demonstrate exceptional accuracy and transferability across all asymptotic parameters, achieving an R2 of 0.999 for both protein fragments and 20 amino acid dipeptide test sets. The long range electrostatic and dispersion energies can be obtained using the the E3NN-predited parameters, with an error of 0.07 and 0.02 kcal/mol, respectively, when compared to Symmetry-Adapted Perturbation Theory (SAPT). Therefore, our force fields demonstrate the capability to accurately describe long-range interactions in proteins, paving the way for the nextgeneration protein force fields.
A Dataset of Simple 1-D and 2-D NMR Spectra of Peptides, Including all Encoded Amino Acids, for Introductory Instruction in Protein Biomolecular NMR Spectroscopy
Authors: Daniecki` Noah J. , Costantini Nicholas V. , Sametz Geoffrey M. , Zondlo Neal J.
Published: March 2024

NMR spectroscopy is the most important technique for understanding the structure of peptides and proteins in solution, providing information at the single-residue and single-atom level. However, written instruction in the interpretation of NMR spectra of peptides and proteins is generally focused on advanced techniques and highly complex spectra, with a lack of simple spectra and guides available for beginning students. In order to address this instructional limitation, we have generated a dataset of 1H NMR spectra of a series of simple peptides that include all canonical amino acids. Peptides examined include Ac-X(S/pS)-NH2, Ac-X(T/pT)-NH2, and Ac-XPPGY-NH2, where X = all encoded amino acids, pS = phosphorylated Ser, and pT = phosphorylated Thr. The characterization of each peptide includes a 1-D spectrum and a TOCSY spectrum, with both the raw and processed available. The spectra can be used for instructional applications including analysis of regions of the spectra (e.g. amide HN, aromatic, Hα, and aliphatic regions); identification of spin systems and residue assignment via TOCSY spectra; analysis of conformational features including amide HN chemical shift dispersion and changes due to hydrogen bonding or post-translational modifications; the 3JαN coupling constant that reports on the φ torsion angle and on order versus disorder at a given residue; conformational preferences at Hα via chemical shift index analysis; understanding of diastereotopic hydrogens; dynamic processes, including hydrogen exchange; and identification of proline cis-trans isomerism. In addition, for a limited number of peptides, NOESY spectra are included to allow sequential resonance assignment and for assignment of trans versus cis proline conformations. Spectra from closely related peptides allow the analysis of the relative effects of single amino acid changes. The paper is written to be directly accessible to students as a tutorial guide. In addition, the data can be used by instructors for problem sets and exams.
Hello Friends, Cantemos: La música en las representaciones de lo latinoamericano en largometrajes de ficción hollywoodenses durante la Política del buen vecino (1933-1945)
Authors: Poveda Juan Carlos
Published: March 2024

Durante las décadas de 1930 y 1940, la industria de Hollywood, con el apoyo del Departamento de Estado de Estados Unidos, produjo una enorme cantidad de películas de propaganda con temas de América Latina. En estas producciones, la música jugó un papel fundamental, siendo uno de los recursos más persuasivos y estratégicos que tenían el gobierno y la industria cinematográfica para apelar a las emocionalidades de sus audiencias, con el fin de favorecer un proyecto de hegemonía. Asumiendo como problema la débil presencia de la dimensión sonora –y dentro de ésta, la musical– dentro de la literatura académica que aborda este fenómeno, esta investigación propone una relectura, desde el punto de vista musical, de un fenómeno representacional que significó, entre Entre otras cosas, la configuración de lo que a partir de entonces se entiende en la industria musical global como “música latina”.
Starvation-resistant cavefish reveal conserved mechanisms of starvation-induced hepatic lipotoxicity
Authors: Pozo-Morales Macarena , Cobham Ansa E , Centola Cielo , McKinney Mary Cathleen , Liu Peiduo , Perazzolo Camille , Lefort Anne , Libert Frédérick , Bai Hua , Rohner Nicolas , Singh Sumeet Pal
Published: March 2024

Starvation causes the accumulation of lipid droplets in the liver, a somewhat counterintuitive phenomenon that is nevertheless conserved from flies to humans. Much like fatty liver resulting from overfeeding, hepatic lipid accumulation (steatosis) during undernourishment can lead to lipotoxicity and atrophy of the liver. Here, we found that although surface populations ofAstyanax mexicanusundergo this evolutionarily conserved response to starvation, the starvation-resistant cavefish larvae of the same species do not display an accumulation of lipid droplets upon starvation. Moreover, cavefish are resistant to liver atrophy during starvation, providing a unique system to explore strategies for liver protection. Using comparative transcriptomics between zebrafish, surface fish, and cavefish, we identified the fatty acid transporter slc27a2a/fatp2 to be correlated with the development of fatty liver. Pharmacological inhibition of slc27a2a in zebrafish rescues steatosis and atrophy of the liver upon starvation. Furthermore, down-regulation of FATP2 in Drosophila larvae inhibits the development of starvation-induced steatosis, suggesting the evolutionarily conserved importance of the gene in regulating fatty liver upon nutrition deprivation. Overall, our study identifies a conserved, druggable target to protect the liver from atrophy during starvation.
Singularity in Rorschach’s Test: 12 Years of Research in Spanish-speaking Countries – A Secondary Publication
Authors: Merino Patricio Meneses , Morales Beatriz Sotomayor , Ferrer Martín Yáñez , Navia Samantha González , Pereira Constanza Irarrázabal
Published: March 2024

To describe the place of singularity in scientific research with the Rorschach test, 85 studies from Spanish-speaking countries published between 2010-2021 are compiled, analyzed, and classified with the “subject approach mode” described by Meneses, and identified for longitudinal trends. The results indicate a growing number of studies using Rorschach in the region with the systematic and stable presence of subject approach considering their singularity. This paper discusses whether the trends represent significance in research with Rorschach in the Spanish-speaking world, compared to studies in the English-speaking world, giving subjects the possibility of being considered in their complexity. It also proposes that the region presents an opportunity to produce research and theoretical models that take advantage of the comprehensive possibilities granted by the Rorschach test as a projective method.
Sífilis Congênita: Epidemiologia dos Casos Notificados em Alagoas, Brasil, 2007 a 2011.
Authors: Alves Waneska Alexandra , Cavalcanti Gabriela Rocha , Nunes Fernanda de Andrade , Teodoro Wender Rodrigues , Carvalho Lorena Miranda de , Domingos Ricardo Silva
Published: March 2024

OBJETIVOS: Caracterizar a ocorrência de sífilis congênita no estado de Alagoas segundo incidência, distribuição regional, perfil epidemiológico e fatores assistenciais das gestantes, e taxa de letalidade. MÉTODO: Estudo do tipo transversal e analítico, de todos os casos de sífilis congênita notificados no estado de Alagoas e contidos no banco de dados do Sistema de Informação de Agravos de Notificação (SINAN), no período de 2007 a 2011. RESULTADOS: Foi encontrada uma incidência média anual de 4,58 casos/mil nascidos vivos, taxa muito além do preconizado pelo Ministério da Saúde (MS), sendo a maioria destes, notificados na mesorregião Leste do estado. Dos casos notificados, a ocorrência foi maior (49,8%) no grupo de mulheres com idade entre 20 e 29 anos, e entre aquelas com baixo nível de escolaridade (60,0%). Foi observado elevado percentual (85%) de gestantes não tratadas ou inadequadamente tratadas para sífilis assim como de parceiros (65,8%). A realização de exames diagnósticos ocorreu em apenas 68,4% das gestantes. A taxa de letalidade no período foi de 10,2%. CONCLUSÃO: A partir deste estudo, fica clara a necessidade de uma maior atenção à doença no estado, com melhoria no sistema pré-natal e acesso ao diagnóstico e tratamento, principalmente entre as gestantes mais jovens e com baixa escolaridade.
Dilemas de uma Formação Médica: Relato de Experiência
Authors: Araújo Cleide Sousa
Published: March 2024

Objetiva-se relatar vivência acadêmica de estudante de Medicina de universidade pública localizada na região nordeste do Brasil. O novo sistema de seleção adotado para ingresso no ensino superior no Brasil, o Sistema de Seleção Unificada (SISU), possibilita ao aluno concorrer a vagas em qualquer estado do país. Por meio do SISU, tive a oportunidade de ingressar em um curso de Medicina em uma universidade pública e inserir-me no universo complexo da formação médica. Incorporar uma nova realidade, longe de familiares e dos amigos conquistados em toda uma vida, aprendendo a administrar com maturidade a rotina muitas vezes exaustiva exigida pelo curso, os desafios do aprendizado no cuidado do outro e aquele ainda maior, o desafio de cuidar de si, são apenas alguns dos dilemas enfrentados durante o percurso. A meio caminho do título de médica, ao passo em que me sinto convicta da escolha que fiz, vejo-me também cheia de incertezas quanto ao mercado de trabalho que me aguarda, ao papel que desempenharei na sociedade e trago ainda comigo muitas aspirações quanto ao meu grau de realização pessoal e profissional.
Função sexual de mulheres submetidas ao tratamento para câncer cervical: revisão integrativa
Authors: Santos José Anderson dos , Farias Karol Fireman de
Published: March 2024

Objetivo: Analisar a função sexual de mulheres submetidas aos tratamentos para o câncer de colo do útero. Métodos: Foi realizada uma revisão integrativa da literatura, em que foram utilizados os descritores em ciências da saúde: “Sexual Behavior”, “treatment” e “Uterine Cervical Neoplasms”, com buscas realizadas nas bases de dados Pubmed, Scopus, Science Direct e Web Of Science. Resultados: Foram localizados 75 artigos, dos quais apenas 9 foram elegidos para esta revisão. Esses estudos foram enfáticos ao afirmarem que a função sexual de mulheres submetidas aos tratamentos para o câncer de colo do útero foi prejudicada. Nestes, foram citados os tratamentos: cirurgia (conização e histerectomia), quimioterapia e radioterapia. Em que a radioterapia foi o tratamento mais frequente e o que mais proporcionou males ao funcionamento sexual dessas mulheres. Os índices de funcionamento sexual se mostraram bem baixo na maioria dos estudos. Conclusão: Portanto, é possível afirmar que mulheres submetidas aos tratamentos para o câncer de colo do útero, seja cirurgia, radioterapia ou quimioterapia, podem ter suas vidas sexuais mudadas. A maioria das pacientes têm dificuldades em voltar a suas atividades sexuais normais.
EXPEDIENTE
Authors: Correia Divanise Suruagy
Published: March 2024

V. 5, N. (2), Abr./Ago. 2020
VELHOS PROBLEMAS E SITUAÇÕES DE SAÚDE SE AGREGAM A COVID-19
Authors: Correia Divanise Suruagy
Published: March 2024

Atualmente, uma das maiores preocupações na área da saúde é com a pandemia da doença do coronavírus de 2019 (coronavirus disease of 2019 - COVID-19) e sua repercussão na vida das pessoas. No início de 2020, a Organização Mundial da Saúde (OMS) assinalou o surto de um novo coronavírus na China; em março a Organização declarou estado de Emergência de Saúde Pública de Interesse Internacional (ESPII) em decorrência da COVID-19. Desde então, muitos estudos sobre a mesma vêm sendo realizados e publicados, inclusive com a necessidades de isolamento social para evitar ou minimizar seu crescimento exponencial.
EMERGENCE OF TALENT ANALYTICS IN HUMAN RESOURCE MANAGEMENT WITH REFERENCE TO MUSIC AND PERFORMING ARTS INDUSTRY IN INDIA
Authors: Kulkarni Priyanka , Namjoshi Asmita , Kalamkar Minal D.
Published: March 2024

The integration of talent analytics into human resource management practices within the music and performing arts industry in India has been a topic of increasing significance. Present research aimed to examine the emergence of talent analytics, its impact on HR management, and the challenges faced by HR managers during its implementation. Employing quantitative methodology, data was collected through a structured survey distributed among 311 HR professionals from various organizations in this sector. The findings highlighted the positive impact of talent analytics on HR practices, showcasing enhancements in decision-making, recruitment efficiency, workforce planning, and talent identification. However, substantial challenges such as financial investments, skill shortages, technical integration hurdles, cultural resistance, and data reliability issues emerged as impediments to seamless implementation. These results underscore the potential benefits of talent analytics while emphasizing the critical barriers that HR managers encounter in leveraging its full potential within this industry.
A FEASIBILITY ANALYSIS IN SMALLHOLDER COFFEE FARMING IN CIBAL BARAT SUBDISTRICT, MANGGARAI DISTRICT
Authors: Prasetyo Kunandar , Cordanis Astried Priscilla , Rachmah Malinda Aptika
Published: March 2024

Kopi merupakan salah satu komoditas perkebunan yang memiliki peranan strategis bagi pertumbungan ekonomi. Pengembangan kopi di Kabupaten Manggarai dihadapkan pada masalah endahnya produktivitas kopi rakyat karena umur tanaman kopi yang sudah tua. tujuan penelitian ini adalah (1) menganalisis karakteristik petani kopi rakyat (2) menganalisis kelayakan usahatani kopi di Kecamatan Cibal Barat, Kabupaten Manggarai. Penelitian ini dilaksanakan di Kecamatan Cikal Barat, Kabupaten Manggarai. Lokasi penelitian dipilih secara purposive atau sengaja dengan pertimbangan bahwa Kecamatan Cikal Barat merupakan salah satu sentra pengembangan kopi di Kabupaten Manggarai. Jumlah sampel yang digunakan yaitu 39 orang. Analisis kelayakan finansial usahatani kopi di Kecamatan Cibal Barat dilakukan dengan menggunakan 3 kriteria investasi usaha yaitu Net Present Value (NPV), Net Benefit-Cost Ratio (Net B/C), serta Internal Rate of Return (IRR). Berdasarkan analisis kelayakan usaha tani yang dilakukan maka usaha tani kopi di kecamatan Cibal Barat di kategorikan masih layak untuk diusahakan. Hasil analisis NPV sebesar Rp 20.094.015, dengan Net B/c 1,26 dan IRR sebesar 23,56%. Rendahnya manfaat bersih yang diterima oleh petani disebabkan karena umur kopi yang sudah tua serta kegiatan budidaya yang masih sederhana
ANALISIS KOMPARATIF PERKEMBANGAN KESEJAHTERAAN PETANI ANTAR SUBSEKTOR PERTANIAN DI PROVINSI NUSA TENGGARA BARAT
Authors: Siddik Muhamad
Published: March 2024

Pembangunan yang dilaksanakan selama ini bertujuan untuk meningkatkan kesejahteraan seluruh rakyat Indonesia. Sampai saat ini rakyat Indonesia, sebagian besar masih tinggal di daerah pedesaan dan bekerja pada berbagai subsektor pertanian. Perkembangan kesejahteraan petani tersebut dapat ditinjau dari perkembangan Nilai Tukar Petani (NTP). Penelitian ini bertujuan untuk membandingkan perkembangan kesejahteraan petani antar subsektor pertanian di Provinsi Nusa Tenggara Barat. Data yang dipergunakan adalah data NTP yang diperoleh dari Badan Pusat Statistik NTB dalam bentuk data time series bulanan selama 11 tahun (2011-2021). Hasil penelitian menunjukkan bahwa petani yang paling dan termasuk sejahtera adalah petani subsektor peternakan, kemudian petani subsektor tanaman pangan; dan petani subsektor perikanan. Sedangkan petani subsektor tanaman hortikultura dan subsektor tanaman perkebunan termasuk katagori belum sejahtera (NTP < 100). Trend perkembangan kesejahteraan petani paling tinggi adalah petani subsektor tanaman pangan, kemudian petani subsektor perikanan, subsektor perkebunan, subsektor peternakan dan yang paling lamban perkembangannya adalah kesejahteraan petani subsektor tanaman hortikultura.
Asymptotic Property of Divergent Formal Solutions in Linearization of Singular Vector Fields
Authors: Yoshino Masafumi
Published: March 2024

We study asymptotic properties of divergent formal solutions appearing in the linearization problem of a singular vector field without a Diophantine condition or existence of additional first integrals. We give an asymptotic meaning to divergent formal solutions constructed from a singular perturbative solution (cf. [6]).