bluuebunny/crossref_metadata_2025 huggingface dataset:
Antidiabetic Activity of Momordica charantia Extracts Through Incretin Pathway in Streptozotocin-Nicotinamide Induced Diabetic Rat Depends on Dose Differences
Authors: Romdhoni Muhammad Fadhol , Doewes Muchsin , Soetrisno Soetrisno , Febrinasari Ratih Puspita
Published: January 2025

Background: This study addresses the increasing prevalence of type 2 Diabetes Mellitus (T2DM) and the need for alternative, cost-effective medications. The research problem focuses on the need to further study the dose effectiveness of Momordica charantia Extracts (MCE) on T2DM parameters, including Glucagon-Like Peptide 1 (GLP-1), Dipeptidyl Peptidase 4 (DPP-4), alpha glucosidase, glucosetransporter 5 (GLUT5), and pancreatic tissue histopathology.
Methods: The methodology employed an experimental research design with 30 Wistar rats divided into six groups, each receiving different inductions and doses. Parameters were measured using Elisa, and histological analysis of pancreatic tissue was conducted using HE staining.
Results: The Kruskal-Wallis test revealed significant differences in each group for the GLP-1 (p=0.003). However, the DPP4 test suggested a lack of significant difference in each group (p=0.192), and the GLUT5 test showed insignificant changes between each group (p=0.119). The ANOVA analysis on alpha-glucosidase revealed no statistically significant differences among the groups (p=0.202). Additionally, a qualitative examination of the histological analysis of pancreatic tissue indicated an improvement in the condition of the pancreatic tissue.
Conclusion: MCE can increase GLP-1 levels, lower DPP-4, lower alpha-glucosidase, and raise GLUT5. However, there are no significant differences between other groups and the morphology of pancreatic tissue in rat model T2DM at a dose of 300 mg/kg.
Isolation and Preliminary Characterization of a Novel scFv against SARS-CoV-2 : an Experimental and Computational Analysis
Authors: Jahandar-Lashaki Samaneh , Farajnia Safar , Alizadeh Effat , Seirafi Farzin , Tanoumand Asghar , Hosseini Mohammad Kazem
Published: January 2025

Background: Since the initial outbreak, the SARS-CoV-2 virus has continued to circulate and mutate, resulting in the emergence of new viral sublineages. Due to the lack of effective protection and therapeutic measures against these new variants, the virus is able to further evolve and diversify. This study aimed to screen a phage antibody library to identify monoclonal antibodies in single-chain variable fragment (scFv) format that target the Receptor Binding Domain (RBD) of different SARS-CoV-2 strains. The newly discovered scFv has the potential for use as a diagnostic or therapeutic option against SARS-CoV-2.
Methods: The RBD protein was produced, purified, and used as an antigen during bio-panning. Six rounds of panning enriched RBD-specific phages and the binding affinity of binders were monitored by polyclonal phage ELISA. Subsequently, monoclonal phage ELISA was employed to identify specific binders. After sequence confirmation, the reactivity of the isolated anti-RBD scFv was evaluated. Additionally, bioinformatics tools determined the interaction between selected scFv and SARS-CoV-2 strains.
Results: The ELISA analysis demonstrated that the expressed RBD retains its structural integrity and effectively interacts with antibodies present in the sera of COVID-19 patients. Through screening a phage display library, a strong-binding scFv for RBD was discovered, which can effectively neutralize SARS-CoV-2 and its novel variants.
Conclusion: The findings of this study have led to the discovery of a novel scFv that effectively neutralizes SARS-CoV-2 strains, offering immense potential for research and therapy purposes.
A Prospective Study on Implementation of Long Term Follow-up of Cured Tuberculosis Patients and Barriers Faced by Health Care Workers at Ahmedabad City, Gujarat: A Mixed Method Approach
Authors: Shah Tejas , Shah Venu , Dave Viral
Published: January 2025

Background: Tuberculosis (TB) remains a major public health challenge in India. Efforts outlined in the National Strategic Plan (2017-2025) are committed to achieve targets towards eliminating TB. Early identification of recurrence among cured TB cases is a crucial strategy towards this goal.  However, there are limited data on the implementation of long-term follow-up for cured cases. Methods: A prospective mixed-method study was conducted to evaluate the implementation of long-term follow-up strategy among 180 cured TB patients. Quantitative assessment involved tracking follow-up visits at 6, 12, 18, and 24 months post-treatment success. Moreover, Focus Group Discussions (FGDs) with 46 TB Health Visitors (TB HVs) were conducted to identify barriers to the implementation of long-term follow-up strategies for cured TB cases.
Results: Quantitative analysis revealed a decline in follow-up visits over time, and only 16.89% of patients were followed up by TB HVs during fourth visit at 24 months post-treatment. Recurrent TB was identified in 22 cases, 13.7% of which were not followed up by health workers. Qualitative analysis highlighted patient-related factors like loss to follow-up due to migration and denial of sputum testing. Health workers cited workload issues and inadequate financial incentives as barriers to implementation.
Conclusion: The study underscores challenges in implementing long-term follow-up strategies for cured TB patients in India. Addressing barriers such as loss to follow-up and workload issues among health workers is crucial for improving recurrence detection and management. Efforts to enhance program effectiveness must prioritize overcoming these barriers to achieve the goal of TB elimination by 2025.
Examination of Healthcare Demand Procrastination Behaviors from a Societal Perspective
Authors: Aslan Yasemin , Özdil Yasemin
Published: January 2025

Background: Health is one of the most fundamental rights of individuals from birth and is guaranteed by national and international texts. This study aims to evaluate individuals' healthcare demand procrastination behaviors from a societal perspective.
Methods: This descriptive cross-sectional study was conducted in the province of Kocaeli, located in the Marmara region of Türkiye. The population of the study consisted of literate individuals aged 18-65 residing in Kocaeli. The sample included 438 individuals who volunteered to participate in the study. Data were collected using a sociodemographic information form and the Healthcare Demand Procrastination Scale (HDPS) through face-to-face interviews employing the convenience sampling method. Descriptive statistics and SPSS 27 software were used for data analysis.
Results: Women were found to have statistically significantly higher total scores on the HDPS compared to men (p = 0.016; p < 0.05). Married individuals had significantly lower total scores for procrastination behaviors than single individuals (p = 0.015; p < 0.05). Participants with low income and no social security exhibited more healthcare demand procrastination behaviors (p = 0.015; p = 0.042; p < 0.05). A weak but significant negative relationship was found between age and procrastination behavior (r = -0.133; p = 0.005; p < 0.01).
Conclusion: To achieve a healthy society, it would be beneficial to implement policy regulations aimed at protecting disadvantaged groups who cannot seek healthcare services when needed due to various reasons.
Diagnostic of Fatty Acid Extracted from Peganum Harmala Seed and Effect Study on The Growth the Leishmania Tropica Promastigotes In Vitro
Authors: Ayad Faris Nahedh
Published: January 2025

Fatty acids were isolated from the seeds of Peganum harmala, a legume, with petroleum ether. The fatty acids were analyzed using HPLC and were determined to comprise 48.9% Hexadecanoic acid, 2.3% Heptadecanoic acid, 13.7% Octadecanoic acid, and 2.8% Tetradecanoic acid. The current investigation demonstrated that the fatty acids extracted from the seeds of Peganum harmala are more advantageous. The current study's data revealed significant differences p<0.05 across various doses of the petroleum ether oil extract of Peganum harmala and differing exposure durations. The study's findings indicated that the 4 mg/dl dose of the oil extract exhibited the highest inhibitory activity against Leishmania tropica at 24 h  22.50 ± 1.04, 48 h 41.50 ± 1.19, 72 h 64.75 ± 2.66, and 96 h 101.25 ± 0.25. Conversely, the lowest inhibitory dose of 1 mg/dl was recorded at 24 h 66.00 ± 2.20, 48 h 108.75 ± 1.65, 72 h 154.50 ± 1.71, and 96 h 207.00 ± 1.91, in comparison to the control groups 75.25 ± 0.85, 156.00 ± 1.83, 320.00 ± 2.16, 522.50 ± 9.31respectively.
Fatty acids exhibited a beneficial effect in suppressing the proliferation of the Leishmaniasis cutanea parasite, namely Leishmania tropica promastigotes, ex vivo.
This research presents a possible alternative to pharmaceutical substances, such as streptolyticum, utilized in treating the parasite responsible for cutaneous Leishmaniasis.
This study concludes that fatty acids extracted from harmful plant seeds enhance the parasiticidal efficacy with increasing concentration, and prolonged treatment duration correlates with a more significant percentage of parasite elimination.
Graph-Based Algorithms for Optimizing Data Flow in Distributed Cloud Architectures
Authors: Pasham Sai Dikshit
Published: January 2025

Improving data communication in DCAs can help correspondingly improve the system's intrinsic performance, scalability, and dependability. With the complexity of cloud environments ever rising, efficient data messaging across multiple nodes is sometimes a significant issue. Thus, graph-based algorithms, derived from graph theory, provide ferm methods of solving these issues as data flow is presented in the form of graphs based on interconnected nodes and edges. This paper aims to highlight how different graph base algorithms including shortest path algorithms, flow optimization as well as load balancing algorithms can be used to enhance the data flow in distributed cloud systems. Using such algorithms can help the cloud providers optimize allocation, reduce response time, build in redundancy, and increase network utilization. The paper also points out the drawbacks connected with these algorithms, such as scalability and computational complexity. They also indicate future research areas, such as applying more advanced features from machine learning and the employment of quantum computing to enhance the graph-based optimization approach. Overall, this work offers insight into the applicability of the graph theory on flows to achieve data flow effectiveness in enhancing the performance of distributed cloud architecture.
Fault-Tolerant Distributed Computing for Real-Time Applications in Critical Systems
Authors: Pasham Sai Dikshit
Published: January 2025

Distributed computing particularly, fault tolerant systems has indispensable functionality in maintaining the dependability and availability of the actual time applications across various sectors including but not limited to healthcare, aerospace, transportation, and industrial control systems. Such systems should run continuously, though there may be equipment problems or network interruptions and software glitches. The major concepts, ways and issues concerning fault-tolerant distributed computing for real time applications in safety critical systems have been discussed in this paper. They include redundancy, replication, consensus algorithms, error detection, and recovery strategies, about which the course notes stress how they ensure that system integrity is sustained during failure modes in addition to satisfying real-time constraints. Exploiting case analysis, we consider fault-tolerant application of these approaches in different sectors as critical environments with an acute necessity for fault-tolerance mechanisms. The paper also presents present day problems such as scalability, performance in fault conditions, and the effectiveness/cost ratio. Last, a consideration of future work in self-organizing and self-healing frameworks that incorporate machine learning, quantum computing, and such other related technologies aimed at achieving better fault tolerance for real-time, distributed systems is made. The role of building and designing infallible, high availability system redundancy models for the assurance of safety, speed, and uninterruptible functionality of such systems is further highlighted by this work.
Graph-Based Models for Multi-Tenant Security in Cloud Computing
Authors: Pasham Sai Dikshit
Published: January 2025

Multi-tenant cloud computing scenarios have a high level of security risks because tenants share the same hardware and network. Control of data privacy, access to resources and isolation of these resources pose a significant challenge. Therefore, the security challenges above can be addressed by employing the relatively new and exciting graph-based models that enable a more structured and reasoned representation of the relationships and interactions of tenants, resources, and services. In this paper, graph theory for managing multi-tenant cloud environments has been discussed to improve the security of the cloud environments through the sophisticated control of access, detection of anomalies, and risk assessments. These transformed cloud resources and tenant interaction can be modeled by graphs to build security models that are effective in monitoring risks, detecting pre-identified abnormalities and controlling for them where necessary. Further, the paper presents different graph-based approaches and methods including graph search, community identification and machine learning for anomaly detection for enhancing security of multi-tenanted cloud environments. These models prove to be useful for avoiding cross-tenancy data breaches, framework invasions, and battles for ambitious resources through realistic cases and concrete examples from VM deployment. The work also expresses the limitations of scaling, privacy issues, and compatibility with traditional security models as well as potential research areas considering the combination with AI and blockchain. In conclusion, graph-based models provide a rather sound approach to providing the specific multi-tenant security in the cloud, further developments of which will be crucial to the further improvement of cloud security.
The Urgency of Ammending Jinayat Qanun in Eradicating Cyber Sexual Crime in Aceh, Indonesia
Authors: Abdul Jalil Salam  , Mursyid Djawas  , Abidin Nurdin  , Delfi Suganda  , Dedy Sumardi
Published: January 2025

As a special province in Indonesia with the jurisdiction to enforce Islamic law, Aceh has enacted Jinayat Qanun to regulate criminal actions. However, incidents of sexual offenses in cyberspace remain unregulated. This article seeks to elucidate the necessity for amendments to the Jinayat Qanun, particularly for instances of sexual offenses in cyberspace. It employs empirical research methodologies assessed via a legislative framework utilizing system theory. Data was gathered through meticulous literature review and extensive interviews. This study reveals that online prostitution has emerged as a global concern, reflecting the adverse effects of contemporary advancements. In Aceh, the currently enacted Jinayat Qanun is perceived as necessitating ammandments. These modifications are tailored to the evolving conditions of society. According to system theory, Jinayat Qanun substantially addresses the issue of online prostitution implicitly. However, obstacles persist within the legal framework and cultural context. Indonesia's legal structure and cultural dynamics, particularly in Aceh, pose significant challenges, underscoring the need for collaboration among various stakeholders, including judges, prosecutors, law enforcement, ulama, and community leaders.
Book of Abstracts: XVIII FeSBE Regional Meeting - Uberlândia
Authors:   Federação de Sociedades de Biologia Experimental (FeSBE)
Published: January 2025

The theme of 18th Regional Meeting of the Federation of Experimental Biology Societies (FeSBE) was ‘Frontiers of Science: Exploring New Horizons.’ The meeting took place 15 to 18 May 2024 and was hosted by the Federal University of Uberlândia (UFU). Holding the 18th Regional Meeting in the Triângulo Mineiro allowed established and developing researchers and students of all levels to build fruitful relationships with academics from different backgrounds and from the most diverse areas of knowledge. FeSBE was founded in 1986 and brings together 24 scientific societies. Its main objective is to disseminate knowledge in defence of issues relevant to the development of science.
Does minimally invasive anatomical hepatectomy reduce surgical site infections?
Authors: Maeda Tetsuya , Ito Yuko , Hosaka Hiroka , Yamazaki Seiko , Kajiwara Yoji , Onishi Ken , Okada Rei , Matsumoto Yu , Kimura Kazutaka , Ishii Jun , Tsuchiya Masaru , Otsuka Yuichiro
Published: January 2025

Aim: This study aims to clarify the effectiveness of laparoscopic anatomical liver resections (ALRs) in surgical site infections (SSIs).

Methods: We included 95 cases (44.0%) of laparoscopic ALRs (LALRs) and 121 (56.0%) of open ALRs (OALRs). Retrospective comparisons were performed between the two groups.

Results: In preoperative factors, tumor size was significantly smaller in LALRs than in OALRs (34.4 ± 23.0 mm vs . 45.9 ± 35.7 mm, P = 0.007). The operative duration was longer in LALRs than in OALRs (523.0 ± 186.5 min vs . 356.3 ± 100.5 min, P < 0.001). However, the blood loss and the blood transfusion were fewer in LALRs than in OALRs (592.1 ± 911.7 mL vs . 1,240.6 ± 1,131.8 mL, P < 0.001, 26.3% vs . 48.8%, P = 0.001, respectively). Postoperative complications above the Clavien-Dindo grade IIIb were one case (1.1%) in LALRs and two in OALRs (P = 1.000). The postoperative hospital stay was shorter in LALRs than in OALRs (14.8 ± 16.5 days vs . 20.7 ± 18.9 days, P = 0.017). There was one (0.8%) postoperative death within 90 days in OALRs and none (0.0%) in LALRs (P = 1.000). Incisional SSIs (ISSIs) were significantly reduced in LALRs than in OALRs (1.1% vs . 7.4%, P = 0.045). Organ/space SSIs (OSSIs) were observed in five cases (5.3%) in LALRs and seven cases (5.8%) in OALRs (P = 1.000). A strong correlation between bile leakage and OSSIs was found. Although OSSIs (Odds ratio 31.200, P = 0.009) were the significant predictive factors for developing ISSIs in OALRs, no risk factors predicting ISSIs were found in LALRs using Multivariate logistic regression analyses.

Conclusion: Although this is a limited study at a single institution, minimally invasive anatomical hepatectomy can reduce ISSIs.
Histone deacetylases in the regulation of cell death and survival mechanisms in resistant BRAF-mutant cancers
Authors: Biersack Bernhard , Nitzsche Bianca , Höpfner Michael
Published: January 2025

Small-molecule BRAF inhibitors (e.g., vemurafenib and dabrafenib) and MEK (MAPK/ERK) kinases inhibitors (e.g., trametinib) have distinctly improved the survival of patients suffering from BRAF-mutant cancers such as melanomas. However, the emergence of resistance to BRAF and MEK inhibitor-based melanoma therapy, as well as the reduced sensitivity of other BRAF-mutant cancers such as CRC, poses a considerable clinical problem. For instance, the reactivation of MAPK/ERK signaling hampering cell death induction mechanisms was responsible for BRAF inhibitor resistance, which can be correlated with distinct post-translational and epigenetic processes. Histone deacetylases (HDACs) are prominent epigenetic drug targets and some HDAC inhibitors have already been clinically approved for the therapy of various blood cancers. In addition, several HDACs were identified, which also play a crucial role in the drug resistance of BRAF-mutant cancers. Consequently, inhibition of HDACs was described as a promising approach to overcome resistance. This review summarizes the influence of HDACs (Zn2+-dependent HDACs and NAD+-dependent sirtuins) on BRAF-mutant cancers and BRAF inhibitor resistance based on upregulated survival mechanisms and the prevention of tumor cell death. Moreover, it outlines reasonable HDAC-based strategies to circumvent BRAF-associated resistance mechanisms based on downregulated cell death mechanisms.
High density polyethylene with phase change materials for thermal energy management
Authors: Sacchet Sereno , Valentini Francesco , Rizzo Caterina , Po Riccardo , Fambri Luca
Published: January 2025

Phase change materials (PCMs) represent an innovative solution to passively manage device temperature or store heat, taking advantage of the material phase transitions. In this work, the attitude of high density polyethylene (HDPE) for the shape stabilization of three selected organic PCMs with a melting temperature close to 55 °C was investigated. Composites with PCM content in the range of 50-61 wt.% were produced by melt compounding, and lab-scale panels were produced by compression molding. The ability of the supporting olefinic matrix to stabilize the PCM and contain leakage was verified and compared through thermo-mechanical characterization. Moreover, expanded graphite was introduced according to a novel under-vacuum impregnation process in order to provide an extra stabilizing contribution, resulting in an outstanding thermal conductivity increase of up to 1.6 W/m·K, and a maximized enthalpy of 112 J/g. Besides the shape stability, HDPE also improves the mechanical properties of PCM-based composites, as documented by detailed and extended characterization through cold and hot compression tests, flexural tests, Vicat and shore A tests. The thermal management effect of the materials is quantified through infrared thermography, by proportionally relating the temperature lags to the high melting/crystallization enthalpy of the investigated products. In view of thermal management applications in the range of 30-60 °C, the main properties of selected HDPE panels with different PCMs are summarized and compared.
Progress in in situ TEM investigations of halide perovskites
Authors: Hao Lianzheng , Cai Songhua
Published: January 2025

Halide perovskites (HPs) have found wide-ranging applications in photovoltaic and optoelectronic devices, achieving remarkable success due to their unique crystal structure and properties. Given the sensitivity of perovskite materials to external stimuli, it is crucial to understand the intrinsic changes in structure and chemical composition during operational conditions. This understanding could assist researchers in exploring new strategies to enhance the photoelectrical properties and stability of these materials. While many in situ methods, such as in situ X-ray diffraction and in situ photoluminescence, have been employed to investigate the properties of perovskite materials in real-time, in situ transmission electron microscopy (TEM) stands out as an unparalleled technique for observing subtle changes at the micro and even atomic scale. In this review, we summarize recent advancements in studying HPs using in situ TEM. We first introduce studies on the crystallization process of HP crystals through in situ TEM observation, and then categorize research works on the degradation process of HPs driven by different external stimuli, including electron beam, heat, electrical bias, light, and ambient atmosphere. Finally, we highlight several challenges that still need to be addressed in the future. This review aims to present a thorough summary of the existing research and lay the groundwork for future inquiries in this captivating area.
Investigation of the biocompatibility and osteogenic effects of magnesium-doped chloride-containing bioactive glasses
Authors: Ouyang Zechi , Li Piao , Ru Xiaomei , Liu Linghao , Shah Priyen , Liu Ousheng , Hill Robert , Chen Xiaohui , Chen Xiaojing
Published: January 2025

Bioactive glass (BG) degrades in vivo , releasing therapeutic ions and forming an apatite-like phase to repair hard tissues. While many BG-derived materials have been employed clinically, researchers continue to work on improving the physicochemical properties and biological functions of BG due to its inappropriate degradation rate and unsatisfactory bone repair effects. Our previous work revealed that the incorporation of chlorine (Cl) into BG expanded the glass structure, facilitating glass degradation and rapid hydroxyapatite formation. Chloride-containing bioactive glasses (GPCl) showed good osteogenesis effects in vitro and in vivo . However, the fast degradation rate of GPCl may cause a mismatch between bone formation and glass degradation, limiting its bone repair efficacy. This study incorporated various amounts of magnesium (Mg, 0-20 mol%) into GPCl to regulate its degradation behavior and enhance its bone regeneration ability. Four glasses were synthesized using a melt-quench method. The in vitro glass bioactivity was evaluated in α-minimum essential media (α-MEM), while the in vivo osteogenic effect of Mg-doped chloride-containing bioactive glasses (GPMgCl) was investigated on a rat skull critical-size defect and compared with the commercially available bone substitute (Bio-Oss®). Additionally, the blood and main organs of rats were collected to assess the biocompatibility of GPMgCl. Our results demonstrated that Mg delayed the degradation rate of GPCl and the rate of hydroxyapatite formation while maintaining excellent bioactivity in α-MEM. GPMgCl promoted the expression of osteogenic genes osteocalcin (OCN), bone morphogenetic protein 2 (BMP2), and vascular endothelial growth factor (VEGF), and facilitated the formation of the mineralized nodules. Moreover, it exhibited superior osteogenic effects compared to Bio-Oss® in vivo , with GPMg10Cl showing optimal bone regeneration ability. Blood biochemical analyses, blood cell tests, and hematoxylin-eosin staining of organs confirmed the excellent biocompatibility of GPMgCl. Incorporating Mg into GPCl is a promising approach to regulate degradation behavior and enhance osteogenic performance, making GPMgCl a promising bone substitute material to meet future bone repair needs.
Fabrication strategies and microscale sensing functionalities of mechanochromic colloidal photonic crystals for underwater applications
Authors: Qi Feng-Lian , Li Qun , Ding Cai-Feng , Wu Jia-Bin
Published: January 2025

Mechanochromic colloidal photonic crystals (PCs), which typically integrate a self-assembled PC array with a highly elastic medium, exhibit the ability to reversibly respond to external mechanical stimuli by altering the periodicity of PC structures. Nowadays, leveraging visible indications and optical signals for mechanical forces, mechanochromic colloidal PCs have been widely used in reflecting body motion, health monitoring, and communications in daily life. However, despite their extensive applications on land, it is vital to explore the potential of mechanochromic sensing applications underwater, where message transmission mainly relies on body gestures and motions. This review comprehensively examines recent advancements in mechanochromic colloidal PCs and their underwater applications. The first part introduces the response mechanism of mechanochromic colloidal PCs, emphasizing the main principles that facilitate sensing on the microscale. The second part describes the fabrication strategies for constructing these PCs, demonstrating various approaches to establish optical sensors with specific functionalities. The final section discusses the confronted challenges and summarizes the potential opportunities in developing mechanochromic colloidal PCs for underwater sensing applications.
Metrnl plays a crucial role in the regulation of glycolipid metabolism
Authors: Zhang Jia , Wang Guoying , Wang Xiaoran , Liu Xinyu , Zhou Xiaoming
Published: January 2025

An imbalance in the metabolism of glycolipids largely causes numerous metabolic diseases that negatively affect human health. Metrnl plays an important role in glycolipid metabolism and regulates glucose and lipid metabolism through multiple mechanisms. However, the expression level of Metrnl in diseases related to glycolipid metabolism remains controversial. Metrnl can increase the utilization of glucose by tissue cells in glucose metabolism and reduce the adverse effects of a high-glucose environment on the body; in lipid metabolism, it can affect the composition and level of blood lipids, reduce the accumulation of fat, and promote the browning of white fat. The clinical efficacy of exogenously administered recombinant Metrnl needs to be further investigated and verified. This review presents an overview of Metrnl, emphasizing its role in glycolipid metabolism and its association with related diseases. It offers a theoretical foundation for the clinical treatment of glycolipid metabolism-related conditions.
Plan de negocios para la comercialización del jabón líquido antibacterial Bacticlean con extracto de bambú en Lima moderna 2024
Authors:   , Juarez Navarro Bet Sel Fiorella Keila
Published: January 2025

Hoy en día, existe una mayor conciencia sobre la importancia de utilizar productos que sean respetuosos con el medio ambiente, prefiriendo alternativas ecológicas que logren dar beneficios para la piel. El proyecto, denominado Jabones Líquidos Antibacterial BactiClean, tiene como objetivo ofrecer productos formulados con ingredientes naturales como extracto de bambú, glicerina y aloe vera, sin el uso de componentes químicos. Estos ingredientes proporcionan excelentes beneficios para el cuidado de la piel y garantizan la satisfacción del consumidor. BactiClean, al ser una alternativa sostenible para el medio ambiente, emplea empaques biodegradables que se descomponen rápidamente, evitando convertirse en contaminantes y reduciendo el impacto negativo asociado a la producción industrial. El proyecto tiene como objetivo producir jabones líquidos, en un local ubicado en el distrito de Lince, en la Av. Arenales 1920, dentro de un centro comercial. Está dirigido principalmente al sexo femenino en el rango de 25 y 45 años que viven en la zona de Lima Moderna. La estrategia de promoción y comercialización del producto se va a llevar a cabo principalmente en plataformas digitales y de manera presencial en nuestra oficina con mayor énfasis en lo digital, debido a que ello es una tendencia creciente en el mercado, se le dará mayor importancia a este canal. Además, se realizará los envíos mediante servicio de delivery. BactiClean adopta una estrategia empresarial centrada en la diferenciación, ofreciendo una atención personalizada al cliente según a sus preferencias y necesidades, se va a garantizar un tiempo de entrega rápido y eficiente. Se dispondrá de una plataforma amigable, sencilla y 10 con un servicio postventa de alta calidad. El proyecto comienza con una inversión de los accionistas de 51,592 soles y un préstamo bancario de 12,898 soles.
Uso de la teleodontología en odontopediatría en tiempos de pandemia por COVID-19: Revisión de literatura
Authors:   , Landeo Pariona Amparo Beatriz
Published: January 2025

A inicios del 2020, surge el virus que inicia la COVID-19. Por ello, se impusieron limitaciones en las interacciones durante la consulta dental. La teleodontología se volvió una opción para poder brindar servicios dentales a pacientes pediátricos. El propósito de esta revisión de literatura fue determinar el uso de la teleodontología en odontopediatría en tiempos de pandemia por COVID-19, para ello se realizó una búsqueda en las plataformas como: EBSCO, Scielo, LILACS, PubMed y Google Académico respecto a ello. Se halló que la teleodontología fue utilizada con fines de diagnóstico y promoción de la salud bucodental, para medir el conocimiento de los padres sobre salud bucal de los niños, realizar controles dentales de aparatología, medir la actitud y conocimiento de teleodontología por el odontopediatra y; para realizar prevención y control de enfermedades en pacientes especiales.
Medidas de resultado informadas por el paciente más utilizados en cirugía periodontal: una revisión de alcance
Authors:   , Chininin Veliz Natalie Nicole
Published: January 2025

Objetivo: Revisar la literatura disponible para determinar qué PRO y PROM se utilizan más en cirugía periodontal (cirugía resectiva, regenerativa y mucogingival). Datos y fuentes: Dos revisores independientes realizaron una búsqueda bibliográfica en Scopus, PubMed y EMBASE hasta el 28 de diciembre de 2023 para identificar ensayos clínicos aleatorios que informaran el desarrollo y/o el uso de PROM específicas como resultados primarios o secundarios. Selección de estudios: Inicialmente se identificaron 935 artículos. Sin embargo, sólo se incluyeron 57 artículos después de la evaluación del texto completo. Se decidió realizar un análisis cualitativo de los datos obtenidos, agrupados por tipo de cirugía y PRO, para poder detallar cada uno de los resultados. Conclusiones: El tratamiento periodontal quirúrgico tiene muchos beneficios clínicos y mejora la calidad de vida del paciente; sin embargo, puede resultar doloroso e incómodo para el paciente. El uso de PROMs en ensayos clínicos debe seleccionarse adecuadamente para poder evaluar la variable estudiada según las características de los pacientes (edad, sexo, experiencias previas) y con el fin de mejorar las experiencias postoperatorias. Significancia clínica: La inclusión de PRO en ensayos clínicos de cirugía periodontal será beneficiosa para mejorar la atención al paciente al generar perspectivas únicas sobre intervenciones que de otra manera no podrían evaluarse. Sin embargo, es necesario conocer los índices más utilizados para medir cada variable a fin de mejorar la coherencia en la presentación de resultados, garantizando que sean clínicamente útiles con los criterios de valoración primarios.
Humanización de espacios en establecimientos de salud-materno infantil a través del diseño biofílico
Authors:   , Chacon Malasquez Milagros Gianella , Torres Huaman Edu
Published: January 2025

La biofilia en el diseño de infraestructuras de salud tiene un efecto favorable en los pacientes, familias y los especialistas de la salud. Varias investigaciones demostraron que el diseño biofílico ofrece numerosos beneficios psicológicos, emocionales y fisiológicos a sus usuarios. Esta tesis de investigación tiene como objetivo analizar cómo se aplican los criterios del diseño biofílico en un establecimiento de salud para la atención materno-infantil en Lurín. El objetivo es ofrecer ambientes confortables y de calidad que logren uno de los muchos valores positivos del diseño biofílico el cual es la humanización de los espacios. En el proceso metodológico se desarrolló con un enfoque cualitativo, incluyendo la revisión bibliográfica, el estudio de normas, el análisis de proyectos referentes internacionales y el análisis de un referente local. La metodología aplicada se fundamenta en la teoría biofílica de Stephen Kellert, que desarrolla tres tipologías de experiencias con la naturaleza. En primer lugar, se determinó que, la experiencia directa con la naturaleza se debe aplicar utilizando los siguientes elementos o atributos, en el caso de la luz, se enfatiza en maximizar el ingreso de luz a través de ventanales y tragaluces, controlando su intensidad y cantidad a través de parasoles y celosías. Respecto al agua; se propone la instalación de espejos de agua, fuentes y acuarios. Para el aire natural; se recomienda emplear estrategias de ventilación convectiva, inducida y cruzada. En cuanto a las plantas; se incorpora incorporando vegetación en el interior, paredes verdes, terrazas verdes, balcones y jardineras. Por último, se destaca el paisaje natural; considerando el entorno urbano y los ecosistemas aledaños existentes, así como la creación de vistas panorámicas hacia la naturaleza, todo ello, teniendo en cuenta las condiciones climáticas específicas del lugar. Por otro lado, la experiencia indirecta con la naturaleza se debe aplicar...
Mionecrosis diabética: Revisión sistemática de reporte de casos
Authors:   , Palomino Romero Lucero , Huaman Vela Lucia Valeria
Published: January 2025

Introducción: La mionecrosis diabética (MD) es una complicación rara y grave de la diabetes mellitus, caracterizada por la necrosis del tejido muscular esquelético sin la presencia de aterosclerosis ni oclusión de grandes arterias, fue descrita por primera vez en 1965, pero sigue siendo una entidad poco reconocida y mal diagnosticada, lo que puede llevar a un retraso en el tratamiento y a peores resultados clínicos. Metodología: La búsqueda de literatura se llevó a cabo en las bases de datos PubMed, Scopus, Web of Science y EMBASE hasta marzo de 2024. Se incluyeron reportes de caso publicados en inglés, español y portugués que describieran características clínicas, laboratoriales e imagenológicas de pacientes con MD. Resultados: Se identificaron 1038 artículos, 133 cumplieron los criterios de inclusión, reportando un total de 162 casos de MD. La mayoría de los pacientes fueron atendidos en servicios de emergencia (76%). Estados Unidos reportó el mayor número de casos (34%), seguido de India (17.6%) e Inglaterra (11.9%). La edad promedio de los pacientes fue de 45.8 años, con una ligera predominancia en hombres (52.2%). Los síntomas más comunes fueron dolor (95.68%) y tumefacción (54.94%). La glucosa de ingreso y la HbA1c mostraron valores elevados, indicando un mal control glucémico. Conclusiones: El dolor y la tumefacción son síntomas predominantes. Un control glucémico riguroso y la atención multidisciplinaria son esenciales para mejorar el pronóstico de estos pacientes. La variabilidad en los parámetros clínicos y laboratoriales subraya la necesidad de un enfoque personalizado y multidisciplinario en el manejo de esta condición.
Evaluación de la morfología radicular y cavidad pulpar de primeras y segundas molares inferiores en peruanos con tomografía computarizada de haz cónico
Authors:   , Barria Muñoz Alejandra Yilmara
Published: January 2025

Objetivos: Evaluar la variabilidad anatómica en la configuración radicular y cámara pulpar de los primeros y segundos molares permanentes mandibulares presentados en población Peruana con tomografía computarizada de haz cónico Métodos: Este estudio transversal incluyó 50 tomografías computarizadas de haz cónico (TCHC) (21 hombres y 29 mujeres) de individuos peruanos. Un investigador entrenado y calibrado evaluó 100 primeros y 100 segundos molares mandibulares para determinar su morfología radicular y la intercomunicación del conducto radicular. Se analizó la prueba de chi-cuadrado para evaluar las asociaciones. (P<0,05). Resultados: Se encontró una asociación significativa entre la morfología de la raíz y la morfología del conducto radicular. La morfología radicular en dos raíces fusionadas presentó dos o tres conductos radiculares (50% cada uno), mientras que la categoría de dos raíces separadas tiene tres conductos radiculares (62,9%); y la categoría con tres raíces separadas presenta 100% con tres conductos radiculares (p < 0,001). La categoría de dos raíces fusionadas se encerró en el 100% de las intercomunicaciones en formato "C", mientras que la condición de dos o tres raíces separadas se asoció en mayor porcentaje en la intercomunicación Distal Mesiolingual (ML D), con 58,3% y 75% respectivamente, (p<0,001). Finalmente, los primeros molares mandibulares presentaron mayoritariamente tres conductos radiculares (67%), mientras que los segundos molares mandibulares presentaron cuatro conductos mandibulares (64%) (p<0.001). Conclusión: La morfología radicular de los primeros y segundos molares inferiores presenta en su mayoría dos raíces separadas, y cuando están fusionadas, tienen dos o tres canales con intercomunicación en forma de C, y cuando están separadas con dos o tres raíces, en su mayoría presentan 3 conductos con intercomunicación ML D. Asimismo, los primeros molares tienen en su mayoría cuatro conductos radiculares, mientras que los segundos molares tienen tres canales mandibulares.
Spatial and Temporal Analysis of Earthquake Events in Kahramanmaraş on 6 February 2023
Authors: Akyürek Özer
Published: January 2025

Earthquakes are one of the most destructive natural disasters that occur as a result of the energy resulting from the movements of the earth's crust spreading and shaking the earth's surface. Since it is not possible to predict when and where earthquakes will occur, it has become possible to make various inferences and take necessary precautions by analyzing previous earthquakes. Spatial and temporal analysis of natural disasters such as earthquakes with geographic information systems provides useful information to local and global decision-makers in measures to be taken and mitigation studies. The objective of this study is to demonstrate that the general orientation of stress accumulation on fault lines can be monitored by weighted average centre points with the use of Geographic Information Systems (GIS). Spatio-temporal analyses of two earthquakes with a magnitude of 7.7 Mw and 7.6 Mw in Kahramanmaraş and aftershocks were performed. Ten-week spatial distributions of the aftershocks were examined with the weighted average center method and it was determined that the earthquake intensity and average centers shifted towards the north. When the spatial distribution of the earthquake centers is examined with the help of standard deviation ellipses weekly, it has been determined that they show orientation along the Eastern Anatolian Fault System.
MIKE Hidrolojik Model Programı ile Alanya İlçesi Demirtaş-Sedre Çayı Taşkın Bölgesinin Modellenmesi
Authors: Dikici Mehmet , Gökce Tasvire
Published: January 2025

Bu çalışma, küresel iklim değişikliğinin etkileri üzerine odaklanarak, Antalya ilinin Alanya ilçesinde bulunan Demirtaş-Sedre Çayı'nın taşkın risklerini değerlendirmeyi amaçlamaktadır. Küresel iklim değişikliğinin artan yağışlar ve doğal afetler üzerindeki etkileri, özellikle insan etkisinin ve kaynak kullanımının kontrolsüzlüğünün doğal afetlere zemin hazırlama potansiyelini vurgulamaktadır. Bölgesel hidrolojik modelleme yöntemlerinin kullanılmasıyla, Demirtaş-Sedre Çayı havzasında taşkın risklerinin belirlenmesi ve bu risklerin azaltılması için stratejiler geliştirilmesine katkıda bulunması açısından önem arz etmektedir. Demirtaş-Sedre Çayı havzasında belirlenen tehlikeli taşkın bölgelerinin haritalanması ve bu bölgelerde alınabilecek önlemlerin belirlenmesiyle ilgili önemli bilgiler sunmaktadır. Bu bağlamda, doğal ve beşerî etkenlerin taşkın riskleri üzerindeki rolü detaylı bir şekilde incelenmiş ve yönetim için stratejiler önerilmiştir. Bu çalışma, bölgesel ölçekte taşkın yönetimi planlaması ve sürdürülebilirlik açısından önemli bir adım olarak değerlendirilebilir. Ayrıca, küresel iklim değişikliğinin yerel düzeydeki etkilerini anlamak ve bu etkilere karşı dirençli topluluklar oluşturmak için yapılan bu tür çalışmaların önemi de vurgulanmaktadır. Bu makale hem akademik çevrelerde hem de yerel yönetimlerde taşkın yönetimi ve risk azaltma stratejileri konusunda ileriye yönelik çalışmalara ilham verici bir katkı sunmaktadır. Taşkın sonucu oluşabilecek can ve mal kayıplarını önlemek ve yağışı kontrol altına alabilmek amaçlı taşkın projelendirme programları ile bölgenin topoğrafik yapısı ve buna bağlı dem haritası, taşkın debisi veya yağış-akış grafileri ile olası taşkın ihtimallerinin hesaplanması için meteorolojiden ve DSİ (Devlet Su İşleri 13. Bölge Müdürlüğü’nden ) alınan veriler istatiksel, sentetik veya deterministik yöntemlerle hesaplanarak belirlenebilmektedir. Bu doğrultuda tehlikeli taşkın bölgeleri belirlenmiştir. Bu çalışmada Antalya ilinin Alanya ilçesinde bulunan Demirtaş-Sedre Çayı’nın MIKE hidrolojik model programı ile modellenmesi taşkın debisinin hesaplanması ve olası taşkın risklerinin tahmin edilmesi üzerine çalışma yapılmıştır. Taşkın riski belirlenen yerlerin olası taşkın yükseklikleri ve taşkın yayılım alanlarının mevcut durumda ki kritik bölgelerin hava fotoğrafları İHA (İnsansız Hava Aracı) kullanılarak çekilmiş ve sonuç kısmında analizi yapılmıştır. Yapılan analiz sonuçlarına göre taşkın öncesi afet risklerini öngörmek ve yönetebilmek için önem arz etmektedir.
Katı Atık Depolama Sahalarındaki Stabilite Sorunlarının Araştırılması
Authors: Güner Karaca Gökçe Buse , Ordu Şeyma , Ordu Ertugrul
Published: January 2025

Günümüzün en acil çevresel sorunlarından biri, atıkların bertarafı, özellikle de düzenli depolama ile ilgilidir. Yanlış depolama yöntemleri nedeniyle yeraltı sularının kalitesi ciddi şekilde tehlikeye girmiştir. Vahşi depolama sahalarında insan sağlığı ve çevre kirliliğiyle ilgili problemler daha yaygındır. Bu düzensiz depolama sahaları birçok dezavantaja ve ciddi sağlık sorunlarına yol açmaktadır. Bu sebeple, daha önce depolama sahalarında meydana gelen şev göçmelerine neden olan vakalar incelenmiştir. Bu çalışmada, atık stabilitesinin değerlendirilmesine odaklanarak katı atık depolama alanlarıyla ilgili stabilite sorunları araştırılmaktadır. Çalışma, Hekimbaşı, Dona Juana, Gnojna Grora, Hiriya, Payatas ve Xerolakka gibi çeşitli düzenli depolama sahalarındaki şev göçmesi vakalarının analizini içermektedir. Plaxis 2D yazılımı kullanılarak, bu analizlerden elde edilen veriler titizlikle değerlendirilmiş ve en uygun düzenli depolama sahası yönetim stratejilerinin belirlenmesi amaçlanmıştır. Düzenli depolama sahalarındaki şev göçmeleri genellikle uygun olmayan depolama sahası tasarımı, günlük örtü serme ve atık sıkıştırma eksikliği, yetersiz atık ayrıştırma, yetersiz sızıntı suyu drenajı ve gaz tahliyesi ile aşırı şev açısı ve yüksekliğinden kaynaklanmaktadır. Bu koşullardan bir veya daha fazlasının varlığı saha stabilitesinde kayba neden olabilir. Mühendislik kontrollerinin yetersiz olduğu bu sahalarda duraysızlıklar yaşanmaktadır.
Depremde Hasar Gören Tarihi Yapıların Temsiliyetine Yönelik Bir Öneri: Pnömatik Sistem Kullanımı
Authors: İmamoğlu Yılmaz Esra , Baş Güray Yusuf , Yavru Tayfur Emre , Yılmaz Semih
Published: January 2025

2023 yılında Türkiye’de meydana gelen Kahramanmaraş merkezli depremler sonucunda birçok tarihi yapı yıkılmıştır. Bu yapılar şehrin ve şehirlinin kültürel hafızasını temsil ettiği için güçlendirilmesi, yenilenmesi ve onarımı önemli bir gerekliliktir. Ancak, tarihi yapıların yeniden inşa ya da onarım süreçleri, yeni bir yapı yapmaya kıyasla daha maliyetlidir, komplekstir ve uzun süreler alır. Güçlendirme, yenileme ve onarım süreçlerinde, bölgede yaşayanların kültürel hafızalarını taze tutmak amacıyla çeşitli uygulamalar yapılmaktadır. Bu uygulamalara yenilikçi bir öneri olarak, pnömatik sistem kullanımıyla depremde hasar görmüş tarihi yapıların temsiliyeti için model önerisi geliştirilmiştir ve geliştirilen model önerisi uygulama olanakları yönünden irdelenmiştir. Çalışma sonucunda pnömatik sistemin farklı yapı tipleri ve formlarına kısa sürede uygulanabildiği, sistem elemanlarının boyut ve yükseklik kısıtlamasının olmadığı, nakliye ve işçiliğin rasyonel olduğu, sistem malzemelerinin geri dönüşüme uygunluğu sayesinde karbon ayak izinin düşmesine katkı sağlayacağı anlaşılmıştır.
The Impact of River Mouth Sediment Deposition on Flood Risk: The Case Study of The Sakarya River
Authors: Sönmez Osman , Temiz Temel , Demirci Beytullah
Published: January 2025

Flooding is a natural disaster that causes loss of life and property worldwide. Floods can be predicted and their damages can be reduced. Various natural and man-made factors can cause floods. Sediment movement can be counted as one of the causes of floods, albeit rarely. The Sakarya River bed and river mouth is one of the risky areas for flooding due to sediment deposition. Due to the activities of quarries on the Sakarya River, the amount of sediment carried by the river increases, and the damage to the river bed morphology. In rare cases, the mouth of the river is completely closed due to sedimentation, which has caused many disasters such as coastal flooding and capsizing of marine vessels, leading to loss of life and property. Therefore, the occurrence of floods due to sediment deposition at the mouth of Sakarya River was investigated. The 5, 10, 25, 50, 100, and 500-year return period flows in the downstream part of the Sakarya River and Karasu district were analyzed with the 2D flood model in case of insufficient discharge from the river mouth. Water depth, velocity, and flood hazard maps for these return periods were prepared. The impact of flooding on Karasu district was analyzed in terms of affected buildings and affected area (ha). Thus, the effects of the floods occurring in the downstream region as a result of the interventions to the river bed in the upstream region were analyzed.