bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Fentanyl on pancreatic cancer cell proliferation and cancer stem cell differentiation
Authors: Celik Feyzi , Duran Tugce
Published: October 2019

Pancreatic cancer is one of the most aggressive cancer due to the late diagnosis and failure to respond to the treatment despite advances in tumor biology and the development of new cancer therapeutic strategies. It has been reported that these characteristics of pancreatic cancer originate from cancer stem cells within the tumor mass. It has also been reported that Fentanyl is a fast-acting analgesic that binds to the mu-opioid receptors and some other mu-opioid receptors are involved in this cancer process. In this study, we determined the effect of Fentanyl on PANC-1 cells, by assessing the gene expression of cancer stem cell marker genes (Nanog, Oct4, and Sox2) and apoptosis-related genes (BAD, Bax, Bcl-2, and p53) by Quantitative RealTime PCR. The number of cancer stem cells was determined by Flow Cytometry. The results of our study showed that Fentanyl administration decreased the number of cancer and cancer stem cells in the PANC-1 cell population, decreased the gene expression of stem cell marker and increased the expression of apoptosis-related genes. These results indicate that Fentanyl, which is used routinely in the pain palliation of pancreatic cancer, can be considered as an option in the treatment of pancreatic cancer.
Coron Problem for Nonlocal Equations Involving Choquard Nonlinearity
Authors: Goel Divya , Rădulescu Vicenţiu D. , Sreenadh K.
Published: October 2019

We consider the following Choquard equation:

{

-

Δ
⁢
u

=

(

∫
Ω

|

u
⁢

(
y
)

|

2
μ
*

|

x
-
y

|

μ

⁢

𝑑
y

)

⁢

|
u
|

2
μ
*

-
2

⁢
u

in 
⁢
Ω

,

u

=
0

on 
⁢

∂
⁡
Ω

,

\left\{\begin{aligned} \displaystyle-\Delta u&\displaystyle=\Bigg{(}\int_{% \Omega}\frac{|u(y)|^{2^{*}_{\mu}}}{|x-y|^{\mu}}\,dy\Bigg{)}|u|^{2^{*}_{\mu}-2}% u&&\displaystyle\phantom{}\text{in }\Omega,\\ \displaystyle u&\displaystyle=0&&\displaystyle\phantom{}\text{on }\partial% \Omega,\end{aligned}\right.

where Ω is a smooth bounded domain in

ℝ
N

{\mathbb{R}^{N}}

(

N
≥
3

{N\geq 3}

),

2
μ
*

=

2
⁢
N

-
μ

N
-
2

{2^{*}_{\mu}=\frac{2N-\mu}{N-2}}

. This paper is concerned with the existence of a positive high-energy solution of the above problem in an annular-type domain when the inner hole is sufficiently small.
Repensar la educación y la pedagogía: algunas reflexiones críticas
Authors: Cascante Gómez Lode E. , González Alvarado Francisco
Published: October 2019

Recibido 1 de noviembre, 2007 • Aprobado 20 de marzo, 2008

 

Reflexionar sobre la escuela como un lugar de construcción cultural permanente, influida por múltiples relaciones; pero, a la vez, como el lugar donde éstas se mediatizan y se construyen otras nuevas, se torna necesario. Valorar que los diseños curriculares explicitan y condicionan las prácticas escolares, y determinan, en buena medida, la intencionalidad de las prácticas pedagógicas es una cuestión que no se debe dejar de lado, en cualquier análisis sobre la educación y la pedagogía.

Estas ideas constituyen los ejes sobre los cuales se articulan las reflexiones de este escrito, las cuales, lejos de plantearse, sólo como cuestiones, puramente, teóricas, se visualizan como posibilidades prácticas. Los argumentos que aquí se expresan recogen las preocupaciones, más importantes, de los autores, y constituyen el resultado aproximado de la lectura y la reflexión sobre la práctica pedagógica personal, desde las aulas universitarias y la experiencia de trabajar con jóvenes de secundaria.
Influencia del cine en la Generación del 27
Authors: Lobato Flora
Published: October 2019

Recibido: 19 de marzo, 2008 • Aprobado: 22 de abril, 2008Este artículo se centra en la influencia que el cine ejerció en la literatura. La aparición del cinematógrafo supuso una revolución en lo cultural; y el mundo de la imagen vino a sumarse a otras artes milenarias, como la pintura y la literatura, las cuales habían servido al hombre para expresar ideas y sentimientos. El cine se considera una rama más de las vanguardias, y, así, el genio creativo de nuestros poetas de la Generación del 27 se vio fructificado, accediendo a territorios antes no explorados por ellos, con lo que sus imágenes y metáforas sobrepasaron los límites conocidos y se adentraron en un universo nuevo, marcado por lógicas de carácter más aperturista.
Maestría en educación rural centroamericana: hacia un modelo pedagógico flexible
Authors: Carvajal Jiménez Vivian
Published: October 2019

Recibido 11 de setiembre 2007 • Aprobado 20 de noviembre 2007

 

 

La Maestría en Educación Rural Centroamericana se propone ante la comunidad nacional e internacional, como un posgrado de alto nivel, cuyo objeto es mejorar la calidad de los procesos educativos formales y no formales en la región centroamericana, a través de un modelo pedagógico innovador que recoge la itinerancia por el istmo y la educación presencial y a distancia con componente virtual. Asimismo, sustenta su práctica en el desarrollo de un modelo flexible, en la inclusividad y en una propuesta metodológica y evaluativa diferenciadas, que recuperan los saberes construidos en cada país centroamericano alrededor del tema de la educación rural.
Caracterización de la situación idiomática de los pueblos indígenas de Costa Rica y su influencia en su educación
Authors: Vásquez Carvajal Ana Cecilia
Published: October 2019

Recibido 12 de julio 2007 • Aprobado 15 de octubre 2007

 

Este ensayo muestra la realidad de los pueblos indígenas costarricenses en cuanto al dominio y promoción de su lengua original y la forma en que esta se toma en cuenta en los planes de estudio que se imparten en las escuelas de estas comunidades. Se afirma que el proceso educativo se desarrolla ajeno a la realidad idiomática y cultural de estos pueblos, y aun cuando se han realizado esfuerzos ministeriales, tienen debilidades que impiden avances significativos. Como resultado de estas deficiencias se genera un debilitamiento cultural que puede culminar con la pérdida de las lenguas nativas.
El abuso sexual a niñas, niños y adolescentes: un secreto familiar, un problema familiar, un problema social
Authors: Palacios José Rodolfo
Published: October 2019

Recibido 30 de noviembre 2007 • Aprobado 12 de diciembre 2007

 

 

La investigación que da origen al artículo, busca señalar cómo, a través de procesos educativos, se puede prevenir y erradicar el abuso sexual a niños, niñas y adolescentes en las comunidades rurales de El Salvador, Guatemala, Honduras y Nicaragua.

Para tal fin, se parte desde la afirmación que el abuso sexual no puede abordarse de manera aislada, se requiere de acciones integrales y comprometidas de los garantes y las instancias responsables del desarrollo y protección integral de las niñas, niños y adolescentes.

Esto implica considerar el marco legal existente, la respuesta que ofrecen las organizaciones gubernamentales, no gubernamentales, públicas y privadas, hacia la prevención, atención, sanciones y restitución de derechos violentados; el papel de las familias como principales responsables del bienestar de sus hijos e hijas y el rol de los niños, niñas y adolescentes.
Semblanza y liderazgo de Omar Dengo: vigencia de su pensamiento
Authors: Alfaro Rodríguez Magdalena , Vargas Dengo Marie Claire
Published: October 2019

Recibido 29 de noviembre de 2007 • Aprobado 17 de junio de 2008 • Corregido 5 de mayo de 2009 Aspectos de la vida de Omar Dengo delinean su obra y lo definen como figura de connotado liderazgo humanista. Su quehacer docente y compromiso social se reflejan en su acción civilista que trasciende su época y aún hoy es vigente.
Calidad de vida, sentido de coherencia y satisfacción laboral en profesores (as) de colegios técnicos en la Dirección Regional de Heredia
Authors: Ureña Bonilla Pedro , Castro Sancho Carmen
Published: October 2019

Recibido 2 de setiembre de 2008 • Aprobado 23 de marzo de 2009 • Corregido 15 de abril de 2009

 

 

El propósito del estudio fue analizar la calidad de vida, el sentido de coherencia y la satisfacción laboral en docentes de colegios técnicos de la región de Heredia. Participó un grupo de 81 educadores(as): 25 hombres y 56 mujeres. Se aplicó el cuestionario SF-36, las escalas de Sentido de Coherencia y de Satisfacción laboral. Los resultados encontrados mostraron la existencia de tres factores importantes relacionados con el bienestar laboral de los(as) educadores(as): el primero de ellos vinculado con el ambiente social y el reconocimiento del trabajo, el segundo asociado a las condiciones infraestructurales, remuneración y de ascenso y el tercero, caracterizado por el tipo y cantidad de trabajo y la relación con los estudiantes. Especialmente crítica resultó la satisfacción laboral de los(as) encuestados(as) en relación con las condiciones de infraestructura, posibilidades de ascenso y de remuneración. La calidad de vida es, en términos generales, aceptable; sin embargo en aspectos centrales como la vitalidad, se evidenció un deterioro importante. Los aspectos mejor calificados se refirieron a la función física y al rol físico. El sentido de coherencia mostró calificaciones aceptables, tanto para el factor vida como para el factor sentimientos. Ambos se relacionaron de manera significativa con dimensiones centrales de la calidad de vida y del bienestar laboral. En general, los resultados encontrados hacen evidente la necesidad de desarrollar e implementar programas que fortalezcan el sentido de coherencia y la calidad de vida de los(as) educadores(as); asimismo, dejan entrever la importancia de atender el tema de la satisfacción laboral, especialmente teniendo claro que, una buena satisfacción laboral no sólo tiene consecuencias positivas sobre la salud, sino también sobre los niveles de compromiso e identificación del(la) educador(a) con el ejercicio de la profesión.
Validación del software educativo Poliestudio 1.0: informe de investigación
Authors: Fallas M Juan José , Chavarría Molina Jeffry
Published: October 2019

Recibido 14 de agosto de 2008 • Aceptado 29 de abril de 2009 • Corregido 23 de junio de 2009

 

 

 

PoliEstudio 1.0 es una herramienta computacional de licencia gratuita diseñada para el trabajo con polinomios en una variable y fue creado por un equipo del cual forman parte los autores de este artículo. Aquí se documenta la validación cualitativa realizada a este software, con el objetivo de brindar al Sistema Educativo Costarricense un programa educativo validado, que dé respuesta parcial a la problemática que aqueja la formación matemática de los estudiantes de secundaria, en particular, en los temas concernientes a polinomios en una variable y, específicamente, a los estudiantes de octavo año.
Recursos didácticos digitales: medios innovadores para el trabajo colaborativo en línea
Authors: Quirós Meneses Elionay
Published: October 2019

Recibido 19 de agosto de 2008 • Aceptado 29 de abril de 2009 • Corregido 14 de agosto 2009

 

 

 

El propósito de este escrito es dar a conocer el origen, las características y las reglas de Blog, Wiki, Chat, Foro y la herramienta Cmap Tools, aspectos fundamentales para un adecuado uso de estos recursos digitales. Además, el principal aporte que se brinda es explicitar los usos didácticos posibles que ofrecen estos recursos, como una propuesta estratégica dinámica para el trabajo colaborativo en línea.
La investigación como eje transversal en el desarrollo de los cursos de la carrera en la Enseñanza de la Educación Física
Authors: Ureña Bonilla Pedro , Castro Sancho Carmen
Published: October 2019

Recibido 30 de marzo de 2008 • Aprobado 14 de setiembre de 2009 • Corregido 23 de setiembre 2009

 

Este escrito tiene como propósito fundamental ofrecer una serie de reflexiones y consejos prácticos introductorios, para utilizar la investigación como eje transversal dentro de la estrategia pedagógica definida, para los cursos de las carreras que ofrece la Escuela Ciencias del Deporte. En términos generales, se plantea el papel de la investigación en la consecución de perfiles profesionales y en el desarrollo de los programas de los cursos. Finalmente, se detalla, a la luz de un ejemplo hipotético, cada uno de los pasos que conforman el protocolo de investigación desde la perspectiva positivista.
Transición 6 grado a 7año, ¿problema o desafío?
Authors: Castro Pérez Marianella , Díaz Forbice Mirta , Fonseca Solórzano Hilda , León Sáenz Ana Teresa , Ruíz Guevara Lillian Susana , Umaña Fernández Willy
Published: October 2019

Recibido 23 de abril de 2009 • Aceptado 20 de mayo de 2009 • Corregido 30 de junio de 2009

 

 

Este artículo despliega los resultados de una experiencia investigativa de dos años, llevada a cabo por un equipo interdisciplinario de las cinco unidades académicas del CIDE. El estudio es parte de un proyecto de investigación más amplio denominado Perfiles, Dinámicas y Desafíos de la Educación Costarricense, el cual es dirigido por el Decanato.

El estudio fue desarrollado durante 2006 y parte de 2007, en colegios identificados como instituciones exitosas con respecto al desempeño académico. La investigación se enfocó en la exploración de los factores que influyen en el desempeño exitoso de los estudiantes cuando ellos transitan de la primaria a la secundaria y a su permanencia durante los años de transición.

La investigación, además de abarcar una revisión literaria importante, requirió trabajo de campo en 10 colegios de diferentes zonas del país. Se realizaron observaciones y se exploraron las creencias de los y las estudiantes de sétimo y octavo año, al igual que las de sus padres, madres y docentes. Además, paralelamente, una importante población de estudiantes de sexto grado, padres, madres y docentes de las escuelas vinculadas con los colegios seleccionados, participaron en el estudio.
La población estudiantil en el sétimo año de la educación pública costarricense
Authors: Alfaro Rodríguez Magdalena , Gamboa Jiménez Alejandra , Jiménez Sánchez Susana , Martín Pérez Jorge R , Ramírez González Andrea , Vargas Dengo Marie-Claire
Published: October 2019

Recibido 31 de julio de 2009 • Aceptado 14 de setiembre de 2009 • Corregido 24 de setiembre de 2009

 

 

 

El estudiantado de sétimo año comparte características que son analizadas en este trabajo, en función del adecuado desempeño docente en la mediación de su aprendizaje, a partir de los resultados de la investigación realizada para el diseño del perfil de desempeño de las y los docentes de este nivel educativo (Alfaro et al., 2008a).

Se concluye que el desarrollo biopsicosocial y el estadio maduracional del tránsito niñez-preadolescencia-adolescencia, debe ser del dominio del profesorado de este nivel, así como el contexto socio-económico familiar y social de sus estudiantes.
Regularities of Signal and Sensitivity Variation of a Reflection Fiber Optopair Sensor Dependent on the Angle between Axes of Fiber Tips
Authors: Kleiza V. , Verkelis J.
Published: October 2019

Regularities of variation of output signal U of one reflection fiber optopair dependent on the distance h between active fiber tips and light reflecting body-mirror (U-h characteristics) and on the angle 2θ between the FAT axes, the distance between FAT being minimal (b = bmin), have been explored by modelling and experimentally. The parameters of U-h characteristics have been established: maximal sensitivity Smax(h), localization and values of maxima and inflection points (+,−) of a function U(h), length of interval ∆h in which the output signal U(h) is linear (98 % of sensitivity maxima), as well as dependences of these parameters on the angle θ and distance h. It has been shown that the experimental results are well described by the formulas improved by the authors previously. It has been demonstrated that reflection fiber optopair sensitivity Smax to displacement considerably increases with an increase of the angle θ. It has been defined that, with an increase of the angle θ up to 20°, sensitivity increases up to 30 times when active fiber tips axes are almost parallel and the diameter of the fiber core is 100 µm, and 125 µm with cladding. Apart from that, Smax increases almost exponentially up to θ = 20°. A drawback of such an RFP is that with an increase of the angle θ, the size of the sensor head also increases. However, due to their considerably increased sensitivity, they can be and are wide used.
Generalized Adaptive Backstepping Synchronization for Non-Identical Parametrically Excited Systems
Authors: Idowu B. A. A. , Vincent U. E. E. , Njah A. N. N.
Published: October 2019

In this paper, we investigate the synchronization of chaotic systems consisting of non-identical parametrically excited oscillators. The backstepping design, which is a recursive procedure that combines the choice of a Lyapunov function with the design of a controller is generalized and employed so as to achieve global chaos synchronization between a parametrically excited gyroscope and each of the parametrically excited pendulum and Duffing oscillator. Numerical simulations are implemented to verify the results.
Mathematical Modeling of a Bioluminescent E. Coli Based Biosensor
Authors: Rabner A. , Martinez E. , Pedhazur R. , Elad T. , Belkin S. , Shacham Y.
Published: October 2019

In this work we present a mathematical model for the bioreporter activity of an E. coli based bioluminescent bioreporter. This bioreporter is based on a genetically modified E. coli which harbors the recA promoter, a member of the bacterial SOS response, fused to the bacterial luminescence (lux) genes. This bioreporter responds to the presence of DNA damaging agents such as heavy metals, H2O2 and Nalidixic Acid (NA) that activate the SOS response. In our mathematical model we implemented basic physiological mechanisms such as: the penetration of the NA into the biosensor; gyrase enzyme inhibition by the NA; gyrase level regulation; creation of chromosomal DNA damage; DNA repair and release of ssDNA into the cytoplasm; SOS induction and chromosomal DNA repair; activation of lux genes by the fused recA promoter carried on a plasmidal DNA; transcription and translation of the luminescence responsible enzymes; luminescence cycle; energy molecules level regulation and the regulation of the O2 consumption.
The mathematical model was defined using a set of ordinary differential equations (ODE) and solved numerically. We simulated the system for different concentrations of NA in water for specific biosensors concentration, and under limited O2 conditions. The simulated results were compared to experimental data and satisfactory matching was obtained. This manuscript presents a proof of concept showing that real biosensors can be modeled and simulated. This sets the ground to the next stage of implementing a comprehensive physiological model using experimentally extracted parameters. Following the completion of the next stage, it will be possible to construct a “Computer Aided Design” tool for the simulation of the genetically engineered biosensors. We define a term “bioCAD” for a Biological System Computer Aided Design. The specific bioCAD that is described here is aimed towards whole cell biosensors which are under investigation today for functional sensing. Usage of the bioCAD will improve the biosensors design process and boost their performance. It will also reduce Non Recurring Engineering (NRE) cost and time. Finally, using a parameterized solution will allow fair and quick evaluation of whole cell biosensors for various applications.
Fenomenologia e Hermenêutica: um desafio para a educação?
Authors: Conte Elaine , Martini Rosa Maria Filippozzi
Published: October 2019

Este artigo resulta de um esforço compartilhado que busca inspiração no diálogo hermenêutico como recurso à imaginação criativa e uma forma de enriquecer o trabalho com as tecnologias da educação. A intenção é analisar, reflexivamente, os estudos de Ricoeur, Gadamer e Habermas realizados acerca da fenomenologia e da hermenêutica,  no sentido de contribuir para a superação da postura descritiva e autoexplicativa inscrita nos discursos pedagógicos. Trata-se de verificar, através da compreensão hermenêutica, as possibilidades para a busca de sentido da ação educativa e, em consequência, para a compreensão do hiato entre o saber pedagógico racional e os novos saberes veiculados pelas tecnologias digitais. O debate problematiza a transição de um paradigma tradicional para a abordagem complexa da integração entre o saber pedagógico e a emergência da virtualidade.
Consciência e liberdade
Authors: Dutra Luiz Henrique de Araújo
Published: October 2019

Este artigo apresenta um modelo do agente livre compatível com as teorias evolutivas e neurofisiológicas da mente e com base especificamente nas noções de liberdade em situação, de Sartre, e de racionalidade limitada, de Simon. Além disso, a noção de agência de controle de Skinner é generalizada, sendo aplicada também ao caso de estruturas cerebrais. O agente livre é descrito como o indivíduo humano cujo eu consciente escolhe e decide no contexto de múltiplas determinações tanto ambientais quanto neurofisiológicas. A autonomia do agente humano é resultado dos processos que levam à aquisição das modalidades da consciência existencial, inclusive a consciência moral. O agente livre é alguém que alcança o autocontrole.
Mimese, idiossincrasia e indústria cultural
Authors: Da Silveira Sara Juliana Pozzer
Published: October 2019

Ao tratar de diferentes aspectos do conceito de mimese na estética de Theodor Adorno, o artigo busca evidenciar a permanência do que Adorno designou como mimese primitiva ou originária na sociedade contemporânea. A análise do conceito de idiossincrasia servirá para mostrar esta permanência e, ao mesmo tempo, o seu reforço pela indústria cultural. Como contraponto a essa faceta do conceito de mimese, trataremos da mimese nos âmbitos científico, filosófico e no que Adorno considera obra de arte autêntica.
A teoria das tradições de pesquisa de Alasdair Macintyre contra o universalismo iluminista, o relativismo e o perspectivismo
Authors: Neto Alberto Leopoldo Batista
Published: October 2019

A teoria das tradições de pesquisa de Alasdair MacIntyre é a sua resposta ao problema da radical discrepância entre perspectivas filosóficas incompatíveis e sua incomensurabilidade prima facie. MacIntyre vê no universalismo iluminista a raiz remota do problema, de modo que desenvolve uma crítica vigorosa de suas pretensões de constituir um campo neutro para o julgamento de teses rivais. Ao mesmo tempo, porém, MacIntyre propõe que uma marca das tradições racionais é a sua tendência a transcender os limites  contingentes de sua origem, aspirando a uma efetiva objetividade, e em linha com tal aspiração, desenvolve também uma crítica sistemática às posições relativistas e perspectivistas. Alguns críticos de MacIntyre veem uma tensão problemática, quando não uma contradição expressa, nessa dupla rejeição de MacIntyre. Busca-se mostrar que o pensamento de MacIntyre escapa a tais objeções e constitui um contraponto eficiente tanto ao universalismo iluminista quanto às posições do relativismo e do perspectivismo.
New records for the Peruvian high-altitude diving beetle Rhantus blancasi Guignot, 1955 (Coleoptera, Dytiscidae, Colymbetinae)
Authors: Balke Michael , Suarez-Megna Yoandri , Hendrich Lars , Zenteno Nilver , Figueroa Luis
Published: October 2019

The diving beetle Rhantus blancasi Guignot, 1955 (Coleoptera, Dytiscidae, Colymbetinae) was until now only known from older reports from Pasco region, Peru. Here, we provide new distributional data from Cuzco and Junin regions, habitat information, and illustrations of diagnostic characters for the easy identification of the species.
Evolution, Cognition, and Horror
Authors: Clasen Mathias
Published: October 2019

Why are people attracted to scary entertainment, to stories and leisure activities designed to evoke negative emotion? How does such entertainment work, and why does it work? Why do we respond with genuine fear to flickering light on a screen? Why do our stories brim with danger and horror and monsters, sometimes far-fetched and utterly implausible monsters? The culmination of that research, so far, is my 2017 monograph Why Horror Seduces. In this article, I will introduce that work, which is the first book-length study of horror from an evolutionary perspective. After a brief introduction to the subject matter, I explain the main theoretical assumptions of the book. I then give a few examples of evolutionary horror theory in analytical and interpretative practice and offer some considerations on the adaptive function of horror. Finally, I reflect on the challenges and benefits of interdisciplinary work and point the way toward future studies.
Effects of High Anxiety Scores on Surgical and Overall Treatment Plan in Patients with Breast Cancer Treated with Neoadjuvant Therapy
Authors: LeVasseur Nathalie , Li Huaqi , Cheung Winson , Myers Paula , Mckevitt Elaine , Warburton Rebecca , Willemsma Kaylie-Anne , Tan Adam Deruchie , Chia Stephen , Simmons Christine
Published: October 2019

Background

Patients with newly diagnosed breast cancer and high levels of anxiety often pursue more aggressive surgical interventions. The neoadjuvant treatment (NAT) setting could provide a window of opportunity to address patients’ anxiety. However, the impact of anxiety on surgical decisions in the setting of NAT for breast cancer has not been previously studied.

Materials and Methods

A prospective database of patients with breast cancer treated with NAT at BC Cancer was used to identify patients treated with NAT and subsequent surgical resection. Patients with bilateral breast cancer or BRCA mutations or those referred to the hereditary cancer program were excluded. An anxiety score of 0–3 was assigned based on responses to the Edmonton Symptom Assessment System and Psychosocial Screen for Cancer. Clinicopathological information and treatment data were retrieved and cross-referenced between the low-anxiety (scores 0–1) and high-anxiety (scores 2–3) cohorts.

Results

From 2012 to 2016, 203 patients met eligibility criteria. Of these, 93 patients (45.8%) had low anxiety and 110 patients (54.2%) had high anxiety. Overall, 161 patients (79.3%) had locally advanced cancers; no differences in stage, grade, or biomarkers were found between the low- and high-anxiety cohorts. Patients with high self-reported anxiety at initial consultation were younger (mean 56 years vs. 60 years; p = .011) and more likely to undergo mastectomy for breast-conserving surgery–eligible disease and bilateral mastectomy for unilateral disease compared with those with low anxiety (37.3% vs. 18.3%; likelihood ratio 9.15; p = .002). No significant differences in treatment timelines were identified between the two cohorts.

Conclusion

Patients with high anxiety at initial consultation were nine times more likely to undergo aggressive surgery compared with patients with low anxiety. These findings underscore the need for early identification of patients who may benefit from tailored supportive and educational services to address sources of anxiety and knowledge gaps.
Microwaved cement boards with alkali-treated pineapple and water hyacinth fibers
Authors: Villanueva Rosanne C , Lim Faye Dominique A , Aleño Jay-Anne B
Published: October 2019

Pineapple fibers (PFs) and water hyacinth fibers (WHFs) were treated with sodium carbonate (Na2CO3) and sodium hydroxide (NaOH) solutions for soaking times of 0·5, 1·0, 1·5 and 2·0 h. Analyses showed that the best treatment parameters for PFs were 2·0 M sodium carbonate for 1·5 h and 2·0 M sodium hydroxide for 0·5 h; those for WHFs were 1·5 M sodium carbonate for 0·5 h and 1·0 M sodium hydroxide for 1 h. The untreated and treated PFs showed similar Fourier transform infrared spectra ranging from 2924 to 2926 cm−1, which signify the presence of acidic oxygen (O)–hydrogen (H) stretching vibrations on a carbonyl group. The sodium hydroxide-treated WHFs had the 2926 cm−1 transmittance peak absent compared with the untreated WHFs. The acetylation process on both fibers resulted in increased roughness of fibers, which were analyzed under scanning electron microscopy of 10 μm magnification. The fibers treated under the determined best parameters were then used in the fabrication of cement boards. The specimens underwent microwave curing with regimes under 119 and 280 W. The cement board with aligned sodium carbonate-treated combined PFs and WHFs performed 16–41% better than the cement board with non-woven oriented fibers in terms of flexural strength.
Eddy current characterization and electrical properties of nanostructured alloy Cu70Fe30
Authors: Laslouni Warda , Azzaz Mohammed
Published: October 2019

The nanostructured copper (Cu)–iron (Fe) alloy exhibits interesting properties compared with a conventional alloy due to the critical size effect. The nanocrystalline solid solution Cu70Fe30 was elaborated from elemental iron and copper powders using a high-energy ball mill. The complete formation of face-centered cubic copper–iron solid solution was obtained after 24 h of milling. A crystallite size of 9 nm was obtained after 36 h of milling. The characteristics of eddy currents and the electromagnetic properties (resistivity and hysteresis loop) of these alloys were studied. The goal was to follow the evolution of the impedance (found from eddy current control) and to establish a relationship between the electrical and magnetic properties and the structure (crystallite size) of the materials.
EFFECT OF POSTGRADUATE EDUCATION ON LIFELONG LEARNING SKILLS: CASE FROM TEACHERS OF SCIENCE
Authors: ERDEN Hale
Published: October 2019

The current study aimed at describing the perceptions of teachers of Science (teachers teaching Science lessons at secondary schools grades from 6, 7 and 8, and teachers teaching Physics, Chemistry or Biology lessons grades from 9, 10, 11 and 12 at high schools) on how postgraduate education affects their lifelong-learning skills. As a qualitative case study, it adopted a descriptive methodology. The study concentrated on 11 postgraduate students studying at various universities at various departments of education faculties who are serving as teachers of Science at the same time at various secondary and/or high schools in North Cyprus. The in-depth interviews, interviews, actual-teaching-time observations and diary-keepings were conducted. Data were analyzed using content analysis from the transcribed interviews, from the diaries kept and from the observation checklists. The results maintained that postgraduate studies provided teachers of Science to improve their instructional competencies and teaching programme; enriched ways of their learning, provided them to develop various types of teaching and learning materials and to apply various types of measurements and evaluation methods for improving their skills on teaching and learning; improved organization and management skills on content, method, events and duration; and facilitated them to conduct researches and do publications.
GÖRSEL MATEMATİK OKUR YAZARLIĞI ÖZ-YETERLİK ALGISI İLE ÜSTBİLİŞSEL OKUDUĞUNU ANLAMA FARKINDALIĞI ARASINDAKİ İLİŞKİ
Authors: AKSU Zeki , ÇALIK UZUN Selcen , ÇELİK Sedef
Published: October 2019

Bu araştırmanın amacı
ortaokul öğrencilerinin görsel matematik okuryazarlık özyeterlik algıları
(GMOÖA) ile üstbilişsel okuduğunu anlama farkındalığı (ÜOAF) arasındaki
ilişkileri incelemektir. Araştırma 2016-2017 eğitim-öğretim yılı bahar
döneminde Doğu Karadeniz Bölgesi’nin bir ilindeki ortaokullarda 7. Sınıfta öğrenim
gören toplam 301 öğrenci ile yürütülmüştür. Araştırmada veri toplama araçları
olarak Duran (2011) tarafından geliştirilen Görsel Matematik Okuryazarlığı
Özyeterlik Algısı Ölçeği (GMOÖAÖ) ile Gelen (2003) tarafından geliştirilip
Çakıroğlu (2007) tarafından Türkçeye uyarlanan Üstbilişsel Okuduğunu Anlama
Farkındalığı Ölçeği (ÜOAFÖ) kullanılmıştır. Araştırma nicel araştırma
yöntemlerinden ilişkisel modele uygun olarak gerçekleştirilmiştir. Analiz için
SPSS 19.0 programından faydalanılmıştır. İlgilenilen değişkenler açısından
cinsiyete göre bir farklılık olup olmadığını tespit edebilmek için analiz
yöntemi olarak bağımsız örneklem t testi kullanılmıştır. Verilerin analizinde
basit korelasyon analizi ve basit doğrusal regresyon analizi kullanılmıştır. Bu
araştırma için görsel matematik okuryazarlık özyeterlik algıları ve üstbilişsel
okuduğunu anlama farkındalığı ölçeğinin Cronbach Alfa güvenirlik katsayıları
sırasıyla .94 ve .77 bulunmuştur. Çalışmanın sonucunda yukarıda bahsedilen
yapılar arasında pozitif yönde orta düzeyde bir ilişki (r= .51) olduğu ortaya
çıkmıştır. Çalışmada öğrencilerin görsel matematik okuryazarlığı özyeterlik
algılarının, üstbilişsel okuduğunu anlama farkındalık düzeylerini pozitif yönde
anlamlı bir şekilde yordadığı sonucuna ulaşılmıştır.
ZİHİN ENGELLİ ÖĞRENCİLERE ÇIKARMA İŞLEMİ ÖĞRETİMİNDE SABİT BEKLEME SÜRELİ ÖĞRETİMLE SUNULAN NOKTA BELİRLEME TEKNİĞİNİN ETKİLİLİĞİ
Authors: BADIR POLAT Tayyibe , YIKMIŞ Ahmet
Published: October 2019

Bu araştırmanın amacı, sabit bekleme süreli öğretim yöntemiyle
sunulan nokta belirleme tekniğinin zihin yetersizliği olan bireylere çıkarma
işlemi öğretiminde etkililiğini, kalıcılığını ve genellemesini belirlemektir.
Araştırmada zihin yetersizliği olan üç öğrenci yer almıştır. Tek denekli
araştırma desenlerinden denekler arası yoklama evreli çoklu yoklama modeli
kullanılmıştır. Araştırmanın bağımsız değişkeni sabit bekleme süreli öğretim
yaklaşımına dayalı olarak sunulan nokta belirleme tekniği, bağımlı değişkeni
ise zihin yetersizliği olan öğrencilerin çıkarma işlemini öğrenmeleridir.
Uygulama süreci, araştırmacı tarafından; yoklama, öğretim, izleme ve genelleme
oturumları olarak düzenlenmiştir. Tüm oturumlar birebir öğretim düzenlemesi ile
gerçekleştirilmiştir. Araştırmanın bulguları sabit bekleme süreli öğretim
yaklaşımına dayalı olarak sunulan nokta belirleme tekniğinin çıkarma
işlemlerinin öğretiminde etkili olduğunu gösterir niteliktedir. Ayrıca,
öğrenilen becerinin öğretim bittikten on gün ve yirmi gün sonrasında korunduğu,
farklı kişilere ve ortamlara genelleyebildiği ve sosyal geçerlikle ilgili
sorulara öğretmenlerin verdikleri cevaplar incelendiğinde sosyal olarak geçerli
olduğu söylenebilir.
ÇAĞDAŞ YAKLAŞIMLARA DAYALI LABORATUVAR UYGULAMALARININ TÜRKİYE'DEKİ ÖĞRENCİLERİN LABORATUVAR DERSLERİNDEKİ TUTUMLARINA ETKİSİ: BİR META-ANALİZ ÇALIŞMASI
Authors: BAYSAL Yunus Emre , MUTLU Fatma , KIŞ Ali
Published: October 2019

Bu
araştırmada, çağdaş yaklaşımlara dayalı laboratuvar uygulamalarının
öğrencilerin laboratuvara yönelik tutumları üzerindeki etkisini inceleyen
çalışmalar meta-analiz yöntemi ile incelenmiştir. Toplam örneklem
sayısının 1406 olduğu bu çalışmada, yayın türleri, ölçek türleri, fen alanları,
uygulama bölgeleri ve deneysel desen türlerinde moderatör analizi yapılmıştır.
Çalışmaların etki büyüklüğü hesaplamaları; heterojenlik, yayın yanlılığı ve ara
değişken analizleri “Comprehensive Meta Analysis” istatistik programı
kullanılarak yapılmıştır. Çağdaş laboratuvar yaklaşımlarının öğrencilerin
laboratuvara yönelik tutumlarına ilişkin genel etki büyüklüğü değeri rastgele
etkiler modeli kullanılarak 0.381 ile 0.733 güven aralığında d=0.557 (%95 CI,
SE=0.090) olarak belirlenmiştir. Cohen, Manion ve Morrison (2007) tarafından
yapılan sınıflandırmaya göre, çağdaş
yaklaşımlara dayalı laboratuvar uygulamalarının, öğrencilerin
laboratuvar derslerine yönelik tutumlarını orta düzeyde etkilediği
belirlenmiştir. Yapılan moderatör
analizleri sonucunda etki büyüklükleri; yayın türleri, çalışılan fen
alanları, uygulama bölgeleri, deneysel desen türlerine ve ölçek türlerine göre anlamlı bir farklılık tespit
edilememiştir.
EULER FORMÜLÜ ÖĞRETİMİNDE 5E ÖĞRENME DÖNGÜSÜ MODELİNE DAYALI DERSLERİN PAYDAŞLARININ DENEYİMLERİ
Authors: BOZ YAMAN Burçak , BULUT Safure
Published: October 2019

5E öğrenme döngüsünün kullanıldığı ders işlenişlerinin olumlu çıktıları uzun yıllardır bilinen bir durumdur. Buna rağmen öğretmenlerin bu ders işlenişlerini çok sık tercih etmemelerinin ardında yatan sebeplerden bir tanesi 5E öğrenme döngüsünü bilmiyor olmalarıdır. Bu nedenle araştırmacıların örnek ders planları ve bu planların işleyişleri üzerine incelemeler yapmaları gerekliliği doğmaktadır. Bu nedenle bu araştırmada örnek bir 5E öğrenme döngüsü planlanmış, uygulanmış ve değerlendirilmiştir. Bu araştırmanın amacı 5E öğrenme döngüsü ve origamiyi temel alarak hazırlanan bir matematik dersinin paydaşlarının derse dair düşüncelerini ortaya koymaktır. Bu amaçla 11. sınıf öğrencileri ile gerçekleştirilen 6 ders saati işleniş, matematik öğretmeni, 5 öğrenci ve araştırmacılarının perspektiflerinden incelenmiştir. Dersin öncesi ve sonrasında görüşme yapılan öğrenciler origaminin geometri sınav sorularında çok karşılaştıkları bir konu olduğunu, işlenen dersin oldukça zevkli, keşfetmeye yönelten ve paylaşımda bulunmalarını gerektiren bir içerikte ders olduğunu belirtmişlerdir. Görüşme yapılan matematik öğretmeni tüm süreci derste gözlemlemiş ve yine işlenen dersin geometri sınav sorularında karşılaşılabilecek içerikte konuya sahip olduğunu ve matematiğin günlük yaşamda ne işe yaradığını anlatabilecek şekilde tasarlandığını söylemiştir. Ancak kendisinin bu tarz bir ders işlemesinin mümkün olmadığını, katlamaya dair bilgisinin olmaması ve zaman sınırlılıklarını gerekçe göstererek dile getirmiştir. Araştırmacılar ise sınıf yönetimi ve 5E öğrenme döngüsü basamaklarının uygulanışlarına dair düzenlemeler yapılması gerekliliğini vurgulamışlardır.
Reflexão sobre as condições de trabalho da enfermagem: subsídio às 30 horas de trabalho
Authors: Bardaquim Vanessa Augusto , Dias Ernandes Gonçalves , Dalri Rita de Cássia de Marchi Barcellos , Robazzi Maria Lúcia do Carmo Cruz
Published: October 2019

OBJETIVO: refletir sobre as condições de trabalho da equipe de enfermagem como subsídio para redução da jornada de trabalho para 30 horas semanais. MÉTODOS: trata-se de uma análise teórico-reflexiva, descritiva, narrativa, realizada a partir de sete artigos publicados nas bases de dados da BIREME e SciELO sobre as condições de trabalho da equipe de Enfermagem no Brasil. REFLEXÃO: as condições de trabalho comprometem a saúde dos trabalhadores. A excessiva carga de trabalho e jornada de trabalho, desgaste físico, problemas na organização do trabalho, elevado grau de responsabilidades e cobranças provocam estresse laboral que reflete na qualidade da assistência, insatisfação com a profissão e interesse em abandoná-la. CONCLUSÃO: as evidencias científicas aludem às 30 horas de trabalhos semanais, para que se possa garantir uma melhor qualidade de vida para a equipe de enfermagem e consequentemente melhorar a qualidade da assistência aos usuários dos serviços de saúde.
О ходе Дохийского раунда многосторонних торговых переговоров урегулирования сельского хозяйства
Authors: Киселев Сергей Викторович
Published: October 2019

По общим вопросам Дохийского раунда переговоры фактически прекратились, несмотря на все активные попытки их возобновить. По этому поводу прошли два заседания Генерального совета. Один Генеральный совет был в октябре, другой — в конце ноября. Какая здесь ситуация? Сформировалось две позиции по Дохийскому раунду. Первая — что надо продолжать, отталкиваясь от тех документов, которые к настоящему моменту уже подготовлены. Последние документы относятся к концу 2008 г., так называемые модальности (modalities). Фактически это калька основных решений, обязательные вопросы для обсуждения. Но они уже в очень подробном виде. Развивающиеся страны, в частности Бразилия и др., говорят о том, что в проекте модальностей декабря 2008 г. многие вещи уже окончательно согласованы и просто надо продолжать эту работу.
Exercise experiences in patients with lung cancer patients: A qualitative approach v1
Authors: Chang Pi-Hua , Lin Ching-Rong , Lee Yun-Hsiang , Liu Yi-Lin , Chang Gee-Chen , Lai Yeur-Hur , Chang Pi-Hua , Veterans General Hospital Taichung
Published: October 2019

Background Patients with metastatic lung cancer have a series of symptoms and many severe treatment-related side effects. However, little evidence is in support of benefits in performing exercise during their hospitalization. The purpose of this study was to understand exercise experiences inpatients with metastatic lung cancer. Methods A qualitative approach with face-to-face in-depth interview was conducted at an inpatient ward of a medical center in central Taiwan, on 24 recruited participants with metastatic lung cancer. The interview transcripts went through a narrative analysis by a group of qualitative research experts to extract and validate the main themes. Results Three primary themes were identified: (a) modifying exercise to maximize physical functions, (b) living with symptoms and frustration but continuing exercise, and (c) doing exercise to sustain hopes, inner power, and life. Two secondary findings were: (a) most participants adopted walking as their main form of exercise because of its flexibility, and (b)participants, according to the severity of their symptoms, adjusted their exercise towards shorter time durations and shorter distances, slower speeds, and higher frequencies. Conclusions Participants with metastatic lung cancer adjusted their exercise behaviors to balance disease and treatment-induced deteriorations and to boost themselves to fight cancer and sustain survival. Individualized exercise schemes should be adopted in clinical practice to enhance their physical functions and life meaning. Such a home-based rehabilitation program in exercise was acceptable to most participants with metastatic lung cancer, including improvements in physical fitness, motivation, and the ability to manage symptoms.
Quantifying Biogenic Silica (bSi) Deposition Rates Adapted Method v1
Authors: N Zepernick Brittany , Saxton Matthew , W Wilhelm Steven
Published: October 2019

This method can be used to assess and quantify the rate of silica deposition (bSi) over time in diatoms to determine their rate of frustule synthesis. This protocol has been adapted for the processing of both cultures as well as environmental samples when inoculated with PDMPO [2‐(4‐pyridyl)‐5‐((4‐(2dimethylaminoethylaminocarbamoyl)methoxy)phenyl)oxazole], which is a fluorescent dye that is co-deposited with silica during frustule biosynthesis in a 3230:1 Si:PDMPO (mol:mol) ratio.
GFP-RFP plate reader assay v1
Authors: Kuiper Sebastiaan
Published: October 2019

Fluorescence measurements of Green fluorescent protein (GFP) and/or Red fluorescent protein (RFP) in Escherichia coli.
Agarose Gel Electrophoresis v1
Authors: Mozaffari Dana
Published: October 2019

Agarose gel electrophoresis is a very common method used to analyze the results of a PCR or any DNA sample in general. It can also be used to purify DNA by gel extraction methods. The underlying principle of gel electrophoresis is that DNA strands of different lengths travel with different speeds through a gel material, when a electrical current is applied. Based on this, it becomes possible to separate DNA in a sample based on the length of the strands and thus access which DNA fragments are present in a sample. The gel material commonly used for dsDNA analysis is agarose powder, dissolved in TAE buffer. The percentage of agarose for optimal spearation depends on the expected length of the samples: it is lower for larger fragments and higher for shorter ones. This protocol describes the fabrication of a X% agarose gel and the run of an agarose gel electrophoresis on a DNA sample.
Production of Recombinant EnvA Rabies Virus v1
Authors: Institute for Brain Science Allen
Published: October 2019

This protocol is used for the large-scale production of EnvA-pseudotyped recombinant rabies virus.
Dental Calculus Field-Sampling Protocol (Sabin version) v1
Authors: Sabin Susanna , A Fellows Yates James
Published: October 2019

This protocol describes how to sample dental calculus from skeletal remains for biomolecular analysis. This protocol is particularly recommended for sampling calculus from teeth attached to a jaw bone, skull, or skeleton. The primary use-case is for DNA and proteomic analysis.
The level of inhibin A in the blood serum of women suffering from chronic trichomoniasis as a predictor of infertility
Authors: Gudinskaya N I , Boyko O V , Gribova N A , Mukhamedzyanova R I
Published: October 2019

Aim. To determine the relationship between the level of inhibin A and biochemical factors of inflammation with the development of infertility in women suffering from chronic trichomoniasis.

Methods. The object of the study was the blood serum of 167 women suffering from chronic trichomoniasis. The level of inhibin A was determined by enzyme immunoassay. As a control, the blood serum of 22 practically healthy fertile women was used who had no history of trichomoniasis. The lymphocyte phenotype was determined using luminescent microscopy with monoclonal antibodies staining. The level of immunoglobulins in serum was determined by the standard Mancini method of radial immunodiffusion. The synthesis of cytokines was determined by the method of studying the spontaneous synthesis of interleukins-1, -8, -10 and interferon . The level of cytokines and lactoferrin was evaluated by enzyme immunoassay. The concentrations of 2-macroglobulin and C-reactive protein were determined by the nephelometric method. The fibrinogen concentration was determined by the coagulometric method.

Results. In the group of patients with chronic trichomoniasis, a significant variability in the serum concentration of inhibin A from 4.3 to 29.4 ng/L was found. In a group of patients who had a reduced content of inhibin A, in 63.2% of cases, the development of secondary infertility was subsequently diagnosed; in the group of patients who had a normal level of inhibin A, secondary infertility developed only in 12.9% of cases.

Conclusion. It was found that among all acute phase proteins, only levels of C-reactive protein and lactoferrin have prognostic value and statistically significantly differ in groups of women with subsequently developed infertility and uncomplicated infertility trichomoniasis.
Development of voluntary medical insurance in the Russian Federation
Authors: Arsentyev E V
Published: October 2019

Aim. To analyze the dynamics of the development of voluntary medical insurance in the Russian Federation. To identify the factors hindering the development of this insurance sector in modern conditions.

Methods. In the course of the study, analysis was conducted of the legislative framework for organizing medical care for the population of the Russian Federation in the system of voluntary medical insurance. The problem-chronological, systematic, and analytical research methods were used.

Results. It has been established that, despite the development of voluntary medical insurance system over the past 25 years, the availability of this type of insurance for citizens of the Russian Federation still remains very low. The policy of voluntary medical insurance is mainly available only to working citizens, and only in those large enterprises where the employer is interested in preserving and protecting the health of its employees. For most citizens of the Russian Federation, the voluntary health insurance policy remains inaccessible due to the high cost of the policy, as well as due to relatively low incomes. At the same time, a voluntary health insurance policy is required by law for labor migrants to obtain a patent for employment in the Russian Federation. However due to the absence of legislative framework for voluntary health insurance, organization of medical care for labor migrants is not always standardized.

Conclusion. For the further development of voluntary medical insurance, it is necessary to develop the measures for decreasing the cost and increasing the availability of a voluntary medical insurance policy for citizens of the Russian Federation; to optimize organization of health care for labor migrants it is necessary to primarily develop regulatory framework of emergency health care.