bluuebunny/crossref_metadata_2025 huggingface dataset:
New Insights into Cerebral Vessel Disease Landscapes at Single-Cell Resolution: Pathogenetic and Therapeutic Perspectives
Authors: Meneri Megi , Bonato Sara , Gagliardi Delia , Comi Giacomo P. , Corti Stefania
Published: July 2022

Cerebrovascular diseases are a leading cause of death and disability globally. The development of new therapeutic targets for cerebrovascular diseases (e.g., ischemic, and hemorrhagic stroke, vascular dementia) is limited by a lack of knowledge of the cellular and molecular biology of health and disease conditions and the factors that cause injury to cerebrovascular structures. Here, we describe the role of advances in omics technology, particularly RNA sequencing, in studying high-dimensional, multifaceted profiles of thousands of individual blood and vessel cells at single-cell resolution. This analysis enables the dissection of the heterogeneity of diseased cerebral vessels and their atherosclerotic plaques, including the microenvironment, cell evolutionary trajectory, and immune response pathway. In animal models, RNA sequencing permits the tracking of individual cells (including immunological, endothelial, and vascular smooth muscle cells) that compose atherosclerotic plaques and their alteration under experimental settings such as phenotypic transition. We describe how single-cell RNA transcriptomics in humans allows mapping to the molecular and cellular levels of atherosclerotic plaques in cerebral arteries, tracking individual lymphocytes and macrophages, and how these data can aid in identifying novel immune mechanisms that could be exploited as therapeutic targets for cerebrovascular diseases. Single-cell multi-omics approaches will likely provide the unprecedented resolution and depth of data needed to generate clinically relevant cellular and molecular signatures for the precise treatment of cerebrovascular diseases.
Is Anodal Transcranial Direct Current Stimulation an Effective Ergogenic Technology in Lower Extremity Sensorimotor Control for Healthy Population? A Narrative Review
Authors: Yu Changxiao , Xiao Songlin , Wang Baofeng , Luo Jiaxin , Liu Cuixian , Zhou Junhong , Fu Weijie , Jin Jing
Published: July 2022

Anodal transcranial direct current stimulation (a-tDCS) aims to hone motor skills and improve the quality of life. However, the non-repeatability of experimental results and the inconsistency of research conclusions have become a common phenomenon, which may be due to the imprecision of the experimental protocol, great variability of the participant characteristics within the group, and the irregularities of quantitative indicators. The aim of this study systematically summarised and analysed the effect of a-tDCS on lower extremity sensorimotor control under different experimental conditions. This narrative review was performed following the PRISMA guidelines until June 2022 in Web of Science, PubMed, Science Direct, Google Scholar, and Scopus. The findings of the present study demonstrated that a-tDCS can effectively improve the capabilities of lower extremity sensorimotor control, particularly in gait speed and time-on-task. Thus, a-tDCS can be used as an effective ergogenic technology to facilitate physical performance. In-depth and rigorous experimental protocol with larger sample sizes and combining brain imaging technology to explore the mechanism have a profound impact on the development of tDCS.
Examining the Impact of Human Face Stimulus on Shape-Contrast Effects during a Brief Presentation
Authors: Qian Kun
Published: July 2022

Shape-contrast effects have been introduced to the investigations into face perception with the aim of exploring face adaptation in the context of norm-based coding. Research has indicated that shape-contrast effects occur even for shapes as complex as the human face. However, whether the complexity of face stimuli alters the magnitude of shape-contrast effects needs to be examined. In this study, emoticons and realistic human faces were used with the original white circle as the test stimuli. The results revealed that the shape-contrast effect was dependent on the stimulus. However, there was no significant difference between the shape-contrast effect evoked by upright faces and that evoked by inverted ones. This suggests that the face stimuli influenced the strength of the shape-contrast effect: the mechanism of this effect involved multiple stages of the visual system related to luminance and complexity, rather than the holistic face perception.
A Case Report of Posterior Reversible Encephalopathy Syndrome (PRES) in a Nonsevere Case of COVID-19
Authors: Cisowska-Adamiak Małgorzata , Sakwińska Katarzyna , Szymkuć-Bukowska Iwona , Goclik Anna , Lunitz Iwona , Mackiewicz-Milewska Magdalena
Published: July 2022

Posterior reversible encephalopathy syndrome (PRES) is a rare complication that the exact pathophysiological mechanism of which is still unclear. PRES most often occurs in connection with severe hypertension and autoimmune diseases. It can also appear during chemotherapy or immunosuppressive treatment. A 38-year-old woman with a negative medical history was admitted to the local hospital due to loss of consciousness accompanied by seizures and high values of blood pressure, and a PCR test for COVID-19 was positive. The patient’s condition was preceded by weakness, wet cough, runny nose, and low-grade fever for three days. Due to the conducted diagnostics after negative CT scans and angio CT studies, an MRI of the head with contrast was performed, where changes characteristic of PRES syndrome were found. During the hospitalization, the patient did not require invasive ventilation and did not receive antiviral drugs or tocilizumab as a result of treatment for her high blood pressure values, and after establishing the diagnosis, the patient was discharged home with a significant improvement in her well-being. In the literature, there are discussions as to whether COVID-19 predisposes patients to PRES. Isolated cases have been described, but its frequency is not yet established. Case reports in the literature appear to be specifically associated with a severe course of the disease, unlike in our patient. Even with a mild course of COVID, the diagnosis of PRES should be taken into account in patients with seizures, visual disturbances, or other focal neurological deficits.
Meaningful Work and Satisfaction with Life: A Case Study from a Supported Employment Program—Colombia
Authors: Grueso Hinestroza Merlin Patricia , Antón Concha , López-Santamaría Mónica
Published: July 2022

Work helps to satisfy instrumental and transcendental needs. For people affected by armed conflict, work has an additional value because it helps them overcome the social disadvantage they suffer; however, topics such as meaningful work—MW—have been poorly studied in this type of population. Based on the above, we propose to analyze the relationship between meaningful work and satisfaction with life in one of the largest private supported employment programs for people involved in the armed conflict in Colombia. To this end, a nonexperimental, quantitative case study was conducted with 62 employees of that employment program. To collect the data, a survey with two measurement scales was administered: Work as Meaning Inventory and Satisfaction with Life Scale. Sociodemographic variables were also obtained. The results demonstrate that meaningful work has a significant effect on satisfaction with life (R2 = 0.28, p < 0.00). We conclude that having meaningful work that provides a sense of belonging, interpersonal connection, and attachment generates greater satisfaction with life in the workers involved in the analyzed program. We also discuss the implications of this research for companies and public policy in Colombia.
Break the Cycle of Collusion: Simulation to Influence Mechanism of Cognitive Bias on To-Collude Decision Making
Authors: Peng Zhengmin , Ye Kunhui , Li Jiale
Published: July 2022

Collusion is an all-pervading illegal market behavior that can undermine the sustainable development of the construction industry. It is acknowledged that collusive bidding decision making is influenced by conspirators’ cognitive bias. Nevertheless, the understanding of such an influence mechanism remains vague in the literature. This study aims to examine the mechanism of conspirators’ to-collude decision making by establishing a system dynamic model. The model development is based on the theories of cognitive biases, collusive bidding, and complex adaptive system. Multiple scenarios were simulated in the context of the Chinese construction industry. Three most influential cognitive bias are overconfidence, the illusion of control, and cognitive dissonance. The simulation results reveal conspirators’ intrinsic mechanisms to decide whether they deserve to participate in collusive bidding. The evolution of to-collude decision making is characterized by nonlinearity, multiplier, and stimulus enhancement effects. Collusion motivation and enterprise network relationships expand conspirators’ to-collude decision making. The increase of government regulation intensity and enterprise performance inhibit conspirators’ to-collude decision making. This study provides an insight into the cycle of collusion emergence from a complex system perspective and implies that antitrust authorities can launch carrot-and-stick measures for better regulation.
Yoda1 Enhanced Low-Magnitude High-Frequency Vibration on Osteocytes in Regulation of MDA-MB-231 Breast Cancer Cell Migration
Authors: Lin Chun-Yu , Song Xin , Ke Yaji , Raha Arjun , Wu Yuning , Wasi Murtaza , Wang Liyun , Geng Fei , You Lidan
Published: July 2022

Low-magnitude (≤1 g) high-frequency (≥30 Hz) (LMHF) vibration has been shown to enhance bone mineral density. However, its regulation in breast cancer bone metastasis remains controversial for breast cancer patients and elder populations. Yoda1, an activator of the mechanosensitive Piezo1 channel, could potentially intensify the effect of LMHF vibration by enhancing the mechanoresponse of osteocytes, the major mechanosensory bone cells with high expression of Piezo1. In this study, we treated osteocytes with mono- (Yoda1 only or vibration only) or combined treatment (Yoda1 and LMHF vibration) and examined the further regulation of osteoclasts and breast cancer cells through the conditioned medium. Moreover, we studied the effects of combined treatment on breast cancer cells in regulation of osteocytes. Combined treatment on osteocytes showed beneficial effects, including increasing the nuclear translocation of Yes-associated protein (YAP) in osteocytes (488.0%, p < 0.0001), suppressing osteoclastogenesis (34.3%, p = 0.004), and further reducing migration of MDA-MB-231 (15.1%, p = 0.02) but not Py8119 breast cancer cells (4.2%, p = 0.66). Finally, MDA-MB-231 breast cancer cells subjected to the combined treatment decreased the percentage of apoptotic osteocytes (34.5%, p = 0.04) but did not affect the intracellular calcium influx. This study showed the potential of stimulating Piezo1 in enhancing the mechanoresponse of osteocytes to LMHF vibration and further suppressing breast cancer migration via osteoclasts.
Type IV Collagen in Human Colorectal Liver Metastases—Cellular Origin and a Circulating Biomarker
Authors: Lindgren Moa , Rask Gunilla , Jonsson Josefin , Berglund Anette , Lundin Christina , Jonsson Pär , Ljuslinder Ingrid , Nyström Hanna
Published: July 2022

Circulating type IV collagen (cCOL IV) is a potential biomarker for patients with colorectal liver metastases (CLM) who present with elevated levels of COL IV in both CLM tissue and circulation. This study aimed to establish the cellular origin of elevated levels of COL IV and analyze circulating COL IV in CLM patients. The cellular source was established through in situ hybridization, immunohistochemical staining, and morphological evaluation. Cellular expression in vitro was assessed by immunofluorescence. Tissue expression of COL IV-degrading matrix metalloproteinases (MMPs)-2, -7, -9, and -13 was studied with immunohistochemical staining. Plasma levels of COL IV in CLM patients and healthy controls were analyzed with ELISA. This study shows that cancer-associated fibroblasts (CAFs) express COL IV in the stroma of CLM and that COL IV is expressed in vitro by fibroblasts but not by tumor cells. MMP-2, -7, -9, and -13 are expressed in CLM tissue, mainly by hepatocytes and immune cells, and circulating COL IV is significantly elevated in CLM patients compared with healthy controls. Our study shows that stromal cells, not tumor cells, produce COL IV in CLM, and that circulating COL IV is elevated in patients with CLM.
New Implications of Patients’ Sex in Today’s Lung Cancer Management
Authors: Raskin Jo , Snoeckx Annemiek , Janssens Annelies , De Bondt Charlotte , Wener Reinier , van de Wiel Mick , van Meerbeeck Jan P. , Smits Evelien
Published: July 2022

This paper describes where and how sex matters in today’s management of lung cancer. We consecutively describe the differences between males and females in lung cancer demographics; sex-based differences in the immune system (including the poorer outcomes in women who are treated with immunotherapy but no chemotherapy); the presence of oncogenic drivers and the response to targeted therapies according to sex; the greater benefit women derive from lung cancer screening and why they get screened less; and finally, the barriers to smoking cessation that women experience. We conclude that sex is an important but often overlooked factor in modern-day thoracic oncology practice.
Encoder-Weighted W-Net for Unsupervised Segmentation of Cervix Region in Colposcopy Images
Authors: Park Jinhee , Yang Hyunmo , Roh Hyun-Jin , Jung Woonggyu , Jang Gil-Jin
Published: July 2022

Cervical cancer can be prevented and treated better if it is diagnosed early. Colposcopy, a way of clinically looking at the cervix region, is an efficient method for cervical cancer screening and its early detection. The cervix region segmentation significantly affects the performance of computer-aided diagnostics using a colposcopy, particularly cervical intraepithelial neoplasia (CIN) classification. However, there are few studies of cervix segmentation in colposcopy, and no studies of fully unsupervised cervix region detection without image pre- and post-processing. In this study, we propose a deep learning-based unsupervised method to identify cervix regions without pre- and post-processing. A new loss function and a novel scheduling scheme for the baseline W-Net are proposed for fully unsupervised cervix region segmentation in colposcopy. The experimental results showed that the proposed method achieved the best performance in the cervix segmentation with a Dice coefficient of 0.71 with less computational cost. The proposed method produced cervix segmentation masks with more reduction in outliers and can be applied before CIN detection or other diagnoses to improve diagnostic performance. Our results demonstrate that the proposed method not only assists medical specialists in diagnosis in practical situations but also shows the potential of an unsupervised segmentation approach in colposcopy.
Association between Temporal Glycemic Change and Risk of Pancreatic Cancer in Men: A Prospective Cohort Study
Authors: Cai Jie , Chen Hongda , Lu Ming , Zhang Yuhan , Lu Bin , Luo Chenyu , Feng Xiaoshuang , You Lei , Dai Min , Zhao Yupei
Published: July 2022

Hyperglycemia has been reported to increase the risk of pancreatic cancer (PC), while the association between glycemic change and PC risk has rarely been explored. Using data from a prospective cohort study conducted in China since 2006, 138,870 males with available fasting blood glucose (FBG) levels, including 106,632 males with at least two FBG measurements, were analyzed. The associations between FBG (level, change, and stability) and PC incidence were evaluated using Cox proportional hazard regression and restricted cubic splines. Baseline (p = 0.109) and recent (p = 0.070) FBG levels and incident PC were not significantly associated. U-shaped associations were observed between the annual FBG change and PC risk. Compared with stable FBG, participants with annual FBG change rates <−0.05 mmol/L or >0.15 mmol/L had about four-fold (HR, 4.010; 95% CI: 1.920–8.375) and six-fold (HR, 5.897; 95% CI: 2.935–11.848) higher PC risks, respectively. The PC risk increased by 2.5% (HRlinear = 1.025, 95% CI:1.009–1.042) for every 1% increase in the coefficient of variation for FBG. A subgroup analysis of males without diabetes at baseline showed stronger associations. Temporal FBG changes may be an important factor for identifying populations with high PC risks.
Recent Advances in Improving Gene-Editing Specificity through CRISPR–Cas9 Nuclease Engineering
Authors: Huang Xiaoqiang , Yang Dongshan , Zhang Jifeng , Xu Jie , Chen Y. Eugene
Published: July 2022

CRISPR–Cas9 is the state-of-the-art programmable genome-editing tool widely used in many areas. For safe therapeutic applications in clinical medicine, its off-target effect must be dramatically minimized. In recent years, extensive studies have been conducted to improve the gene-editing specificity of the most popular CRISPR–Cas9 nucleases using different strategies. In this review, we summarize and discuss these strategies and achievements, with a major focus on improving the gene-editing specificity through Cas9 protein engineering.
PICU Survivorship: Factors Affecting Feasibility and Cohort Retention in a Long-Term Outcomes Study
Authors: Sobotka Sarah A. , Lynch Emma J. , Dholakia Ayesha V. , Mayampurath Anoop , Pinto Neethi P.
Published: July 2022

Our understanding of longitudinal outcomes of Pediatric Intensive Care Unit (PICU) survivors is limited by the heterogeneity of follow-up intervals, populations, and outcomes assessed. We sought to demonstrate (1) the feasibility of longitudinal multidimensional outcome assessment and (2) methods to promote cohort retention. The objective of this presented study was to provide details of follow-up methodology in a PICU survivor cohort and not to present the outcomes at long-term follow-up for this cohort. We enrolled 152 children aged 0 to 17 years admitted to the PICU in a prospective longitudinal cohort study. We examined resource utilization, family impact of critical illness, and neurodevelopment using the PICU Outcomes Portfolio (POP) Survey which included a study-specific survey and validated tools: 1. Functional Status Scale, 2. Pediatric Evaluation of Disability Inventory Computer Adaptive Test, 3. Pediatric Quality of Life Inventory, 4. Strengths and Difficulties Questionnaire, and 5. Vanderbilt Assessment Scales for Attention Deficit-Hyperactivity Disorder. POP Survey completion rates were 89%, 78%, and 84% at 1, 3, and 6 months. Follow-up rates at 1, 2, and 3 years were 80%, 55%, and 43%. Implementing a longitudinal multidimensional outcome portfolio for PICU survivors is feasible within an urban, tertiary-care, academic hospital. Our attrition after one year demonstrates the long-term follow-up challenges in this population. Our findings inform ongoing efforts to implement core outcome sets after pediatric critical illness.
Early Breast Milk Volumes and Response to Galactogogue Treatment
Authors: Asztalos Elizabeth , Kiss Alex
Published: July 2022

The aim of this study was to evaluate the effect of galactogogue management in mothers of very preterm infants with varying breast milk volumes prior to initiating this treatment. Data were utilized from 90 women who participated in a trial employing domperidone. Three groups were formed according to their breast milk volumes (based on their infants’ birth weight) at the time of randomization and study entry to the trial protocol: (1) ≤100 mL/kg/d; (2) 101–200 mL/kg/d; and (3) ≥201 mL/kg/d. Breast milk volumes were evaluated at the 14- and 28-day study treatment periods. All three groups showed a significant volume increase and volume percent increase both at the 14-day measure and also the 28-day measure. Mothers who started in the two lower volume groups showed the greatest % volume change overall, with 356.2% in the ≤100 mL/kg/d and 106.1% in the 101–200 mL/kg/d groups, compared to those mothers in the higher group of ≥201 mL/kg/d, showing a change of 45.2%, where p = 0.001. Mothers producing varying low volumes were able to demonstrate an effect from the use of domperidone and increase their volumes as much as three-hundred-fold over 14- and 28-day study periods. However, those mothers whose volumes were ≤100 mL/kg/d continued to maintain low absolute milk volumes, putting these mothers at ongoing risk of ceasing lactation.
Spatial and Temporal Variations in Shoreline Changes of the Niger Delta during 1986–2019
Authors: Afolabi Matthew , Darby Stephen
Published: July 2022

The purpose of this study was to analyse the shoreline movement of the Niger delta, specifically focusing on the spatial pattern of the delta’s shoreline behaviour during 1986–2019. We employed satellite data of medium spatial resolution (20–30 m) to delimit the delta shorelines representing specific time in order to determine the rates of the delta shoreline migration. Our results show that the delta shoreline has changed nearly in equal proportion between erosion (50.3%) and accretion (49.7%), at mean (maximum) rates of 3.9 m/yr. (26 m/yr.) of erosion, and 4.0 m/yr. (27 m/yr.) of accretion. Further analysis indicates that the highest shoreline migration is seaward (>200 m) though the ratio of the shoreline distance in recession (54%) exceeds that which is in accretion. Our analysis did not reveal any entrenched spatial pattern of shoreline behaviour but rather highlights a random occurrence of hotspots in both shoreline erosion and accretion over space and time. We have also showed that by applying the statistical mean-removed shoreline approach, the overall trend of a delta shoreline movement can be vividly discriminated. In conclusion, since the Niger delta shoreline dynamics is most intense at the delta river mouths, we suggest this is likely due to the interaction between waves and river discharge in these locations.
A Descriptive Study of the Types and Survival Patterns of Saudi Patients with Multiple Primary Solid Malignancies: A 30-Year Tertiary Care Center Experience
Authors: Alhamadh Moustafa S. , Alanazi Rakan B. , Algarni Sultan T. , Alhuntushi Ahmed Abdullah R. , Alshehri Mohammed Qasim , Chachar Yusra Sajid , Alkaiyat Mohammad , Sabatin Fouad
Published: July 2022

Background and Objective: Cancer survival has improved significantly, which reflects the achievements in screening, diagnosis, and treatment. As a consequence, multiple primary malignancies are diagnosed more frequently, with an incidence ranging from 0.52–11.7%. The types of malignancy that coexist and survival patterns vary notably in different countries and geographical areas. Due to the limited literature in Saudi Arabia, a baseline of prevalent malignancy combinations and their survival patterns would support early detection and disease management. Method: This was a retrospective descriptive study conducted from 1993–2022 at King Abdulaziz Medical City, Department of Medical Oncology, Riyadh, Saudi Arabia. Patients with at least two biopsy-proven solid malignancies were included. Patients with hematological malignancies, missing data, or an uncertain or indecisive pathology report were excluded. Result: In total, 321 patients were analyzed. More than half (57.3%) of the patients were female. A third (33%) of the cases were synchronous, and 67% were metachronous. The most frequent site of the first primary malignancy was breast cancer, followed by colorectal, skin, and thyroid cancers. The most frequent site of the second primary malignancy was colorectal cancer, followed by thyroid, breast, and liver cancers. Only 4% of the cases had a third primary malignancy, with colorectal and appendiceal cancers being the most frequent. The most frequently observed histopathology in the synchronous and metachronous malignancies was adenocarcinoma. Breast–colorectal, breast–thyroid, and kidney–colorectal were the most frequently observed malignancy combinations. Conclusion: The current study offers a baseline of multiple primary malignancies in Saudi Arabia and provides supporting evidence that the pattern of multiple primary malignancies varies among different countries and ethnicities. The possibility of developing another primary malignancy should be considered when treating and monitoring cancer patients.
Dataset: Mobility Patterns of a Coastal Area Using Traffic Classification Radars
Authors: Ferreira Joaquim , Aguiar Rui , Fonseca José A. , Almeida João , Barraca João , Gomes Diogo , Oliveira Rafael , Rufino João , Braz Fernando , Gonçalves Pedro
Published: July 2022

Monitoring road traffic is extremely important given the possibilities it opens up in terms of studying the behavior of road users, road design and planning problems, as well as because it can be used to predict future traffic. Especially on highways that connect beaches and larger urban areas, traffic is characterized by having peaks that are highly dependent on weather conditions and rest periods. This paper describes a dataset of mobility patterns of a coastal area in Aveiro region, Portugal, fully covered with traffic classification radars, over a two-year period. The sensing infrastructure was deployed in the scope of the PASMO project, an open living lab for co-operative intelligent transportation systems. The data gathered includes the speed of the detected objects, their position, and their type (heavy vehicle, light vehicle, two-wheeler, and pedestrian). The dataset includes 74,305 records, corresponding to the aggregation of road information at 10 min intervals. A brief analysis of the dataset shows the highly dynamic nature of traffic during the two-year period. In addition, the existence of meteorological records from nearby stations, and the recording of daily data on COVID-19 infections, make it possible to cross-reference information and study the influence of weather conditions and infections on traffic behavior.
Proposal for Practical Approach in Prenatal Diagnosis of Beckwith–Wiedemann Syndrome and Review of the Literature
Authors: Ma Gwo-Chin , Chen Tze-Ho , Wu Wan-Ju , Lee Dong-Jay , Lin Wen-Hsiang , Chen Ming
Published: July 2022

Background: Beckwith–Wiedemann syndrome (BWS) is a phenotypically and genetically heterogeneous disorder associated with epigenetic/genetic aberrations on chromosome 11p15.4p15.5. There is no consensus criterion for prenatal diagnosis of BWS. Methods: Three BWS patients with their clinical histories, prenatal ultrasonographic features, and results of molecular diagnosis were presented. Likewise, by incorporating the findings of our cases and literature review, the phenotypic spectrum and genotype–phenotype correlations of fetal BWS were summarized, and a practical approach in prenatal diagnosis of BWS was proposed. Results: A total of 166 BWS cases with prenatal features were included for analysis. Common fetal features include abdominal wall defects (42.8%), polyhydramnios (33.1%), and macrosomia (32.5%). Molecular pathologies include methylation changes in imprinting control region 1 and 2 (ICR1 and ICR2), paternal uniparental disomy of chromosome 11p15.5, copy number change involving 11p15, etc. Some genotype–phenotype correlations were observed. However, the broad phenotypic spectrum but limited features manifested by affected fetuses rendering ultrasonographic diagnosis not easy. Conclusions: Molecular tests are used for prenatal diagnosis of BWS suspected by ultrasonography. Methylation-specific multiplex ligation-dependent probe amplification (MS-MLPA) is recommended as the first-line molecular tool because it simultaneously detects ICR1/ICR2 methylation statuses and copy numbers that solve the majority of clinical cases in the prenatal scenario.
Shielding Probabilistically Checkable Proofs: Zero-Knowledge PCPs from Leakage Resilience
Authors: Weiss Mor
Published: July 2022

Probabilistically Checkable Proofs (PCPs) allows a randomized verifier, with oracle access to a purported proof, to probabilistically verify an input statement of the form “x∈L” by querying only a few proof bits. Zero-Knowledge PCPs (ZK-PCPs) enhance standard PCPs to additionally guarantee that the view of any (possibly malicious) verifier querying a bounded number of proof bits can be efficiently simulated up to a small statistical distance. The first ZK-PCP construction of Kilian, Petrank and Tardos (STOC 1997), and following constructions employing similar techniques, necessitate that the honest verifier makes several rounds of queries to the proof. This undesirable property, which is inherent to their technique, translates into increased round complexity in cryptographic applications of ZK-PCPs. We survey two recent ZK-PCP constructions—due to Ishai, Yang and Weiss (TCC 2016-A), and Hazay, Venkitasubramaniam and Weiss (ITC 2021)—in which the honest verifier makes a single round of queries to the proof. Both constructions use entirely different techniques compared to previous ZK-PCP constructions, by showing connections to the seemingly-unrelated notion of leakage resilience. These constructions are incomparable to previous ZK-PCP constructions: while on the one hand the honest verifier only makes a single round of queries to the proof, these ZK-PCPs either obtain a smaller (polynomial) ratio between the query complexity of the honest and malicious verifiers or obtain a weaker ZK guarantee in which the ZK simulator is not necessarily efficient.
Optimization of Non-Uniform Perforation Parameters for Multi-Cluster Fracturing
Authors: Zeng Qingdong , Liu Wenzheng , Yao Jun
Published: July 2022

Stress shadowing affects the simultaneous propagation of fractures from multiple perforation clusters. Employing uniform perforation parameters for all clusters cause the unbalanced growth of fractures, which arouses the demand of optimizing non-uniform perforation parameters. An optimization workflow combining a fracture propagation model and the particle swarm optimization method (PSO) is proposed for multi-cluster fracturing in this study. The fracture model considers the coupling of rock deformation and fluid flow along the wellbore and fractures, and it is solved by using the Newton iteration method. The optimization is performed by taking the variance of multiple fracture lengths as fitness value function in the frame of the PSO method. Numerical results show that using the same spacings and perforation parameters for all clusters is detrimental to the balanced growth of multiple fractures. The variance of fracture lengths drops greatly through optimization of cluster spacings and perforation number/diameter. Properly increasing the spacing and perforation number/diameter for the middle clusters promotes the balanced growth of multiple fractures. This study provides an efficient optimization workflow for multi-cluster fracturing treatment in horizontal wells.
Natural Ventilation and Aerosol Particles Dispersion Indoors
Authors: Dbouk Talib , Drikakis Dimitris
Published: July 2022

Aerosol pollutant particles indoors significantly affect public health. The conventional wisdom is that natural ventilation will alleviate the dispersion of airborne or aerosol particles. However, we show that the problem is far more complex and that natural ventilation should be applied under specific conditions to be effective. We performed several simulations of a simplified (and easily reproducible) room with a window opening and aerosol particles stratified layers. Opening a window can scatter particles present in stratified layers indoors and potentially contribute to the degradation of indoor air quality for a significant period of time. Moreover, we show that thermal instabilities arising from the temperature gradients due to temperature differences between the indoor and outdoor environment spread the particles randomly indoors, adversely affecting air quality and architectural design. Recommendations for more efficient natural ventilation minimizing aerosol pollutant particles dispersed indoors are provided.
Technological, Economic, Social and Environmental Barriers to Adoption of Small-Scale Biogas Plants: Case of Indonesia
Authors: Situmeang Ricardo , Mazancová Jana , Roubík Hynek
Published: July 2022

By 2025, biogas is estimated to become a larger part of Indonesia’s energy mix. Biogas is a renewable energy source that also has economic and environmental advantages. Domestic biogas generation has been embraced in Indonesia as a response to the country’s energy security concerns in rural areas. Since the 1970s, 48,038 biogas plants have been built in the region. To fully develop this technology, Indonesia must discontinue relying on fossil fuels and substitute current fossil-fuel-based energy. This article provides an overview of renewable technology in Indonesia, as well as addressing domestic energy demands and referring to existing literature on the socio-technical and socio-economic barriers to biogas adoption in Indonesia. Based on a rigorous review of 71 publications published in Web of Science (WoS) between 2010 and 2021, this study explores existing barriers for biogas adoption by summarizing the current literature from technical, economic, social and environmental perspectives. Biogas adoption is a complex process with many interwoven components. Therefore, this research addresses a gap in the strategic planning and implementation process, providing policymakers with pathways to eliminate bottlenecks in renewable energy planning. Recommendations for future research are also proposed.
Heat Transfer Study from a Salty Droplet Film on a Horizontal Tube in Mechanical Vapor Recompression Crystallization System
Authors: Cao Yanmei , Wang Yu , Gao Yang , Kosonen Risto
Published: July 2022

The horizontal drop film evaporator is a key component of the mechanical vapor recompression crystallization system, which can be used to evaporate effluent and recycle secondary vapor energy. However, the properties of heat transfer and flow of the salty effluent sprayed external of the horizontal drop film evaporation tube are obviously different from that of ordinary water. We established a 3D model for a horizontal drop film evaporator in the system, and water and sodium sulfate mixture were manufactured to reproduce the real salty effluent. By applying the VOF (volume of fluid) model, the liquid-gas interface of a salty effluent spray drop film formed on a horizontal tube in the evaporator was traced. The impacts of various heat flux, sodium sulfate content, spray density, and temperature on the local Nusselt number were studied, and a dimensionless correlation was established. The results showed that the effect of surface tension cannot be negligible; as the sodium sulfate content rises, the local Nusselt number declines in the thermal developing region; as the spray temperature and density rises, the local Nusselt number rises, which was largely independent of the heat flux in the thermal developing region.
Distribution of Upper Paleozoic Coal Seams in the Southeastern Ordos Basin
Authors: Guan Yunwen , Guo Qijun , Pu Renhai , Gao Xiaoping , Chen Shuo , Ji Tianyu
Published: July 2022

The Ordos Basin contains abundant coal resources in the Upper Paleozoic strata. They are shallowly buried or exposed in the periphery of the basin, forming recoverable coal mines and coalbed methane resources. For the deeply buried coal seams of the basin, however, due to complex changes and difficult mining, less attention was paid before. In recent years, with the exploitation of tight gas related to coal source rocks, a large amount of drilling and seismic data has been accumulated in the southeastern Ordos Basin, which makes it possible to study the distribution change and factors controlling Upper Paleozoic coal seams. Delineation of deep coal development and distribution is an important basis for coal, coalbed methane and related tight gas resources in the Upper Paleozoic. We use core, logging and seismic data to analyze the coal geophysics, thickness variation, paleotopography and sedimentary facies in the southeastern Ordos Basin. The lower part of the Shanxi Formation (Fm.) and the upper part of the Taiyuan Fm. in the southeastern part of the basin are characterized by low natural gamma ray, low density, high resistivity and high sonic logging values. As the coal velocity is very low and alternates with the high-velocity Taiyuan Fm. and Ordovician limestones, the two sets of coals below and above the Taiyuan limestones form an extremely strong-amplitude reflection in the seismic profile. The two sets of coals are cumulatively 1–10 m thick, averaging 2.4 m, and 4 m is the maximum induvial thickness. The individual coal seams thicker than 2 m cover an area of approximately 2500 km2, and the burial depths of the coal seam range from 2500 to 3000 m. The thick coal seams of the Taiyuan Fm. are mainly distributed proximally in the Ordovician paleokarst depression, while the Ordovician paleokarst depression without incised origin was deposited by distal coeval limestone rocks. There is a complementary relationship between the coal seams and the thickened zone of distributary channel sandstone in the Shanxi Fm.
Simulating a Macrosystem of Cargo Deliveries by Road Transport Based on Big Data Volumes: A Case Study of Poland
Authors: Naumov Vitalii , Szarata Andrzej , Vasiutina Hanna
Published: July 2022

Simulation models of transport systems are a key tool for solving many problems in the field of management of these systems. The methodologies for creating such models use datasets on both transport infrastructure and demand for the delivery of goods or passenger transport, however, many factors are considered based on assumptions due to the complexity. This article describes the approach to modeling the cargo transportation system for road transport in Poland based on data obtained by the Central Statistical Office from the TD-E survey. This approach avoids many assumptions about demand as the demand parameters are estimated based on a sample representing the general population—a set of all economic entities generating freight traffic. Basic procedures in the developed approach have been implemented as Python scripts. As a result of the use of the proposed methodology, a country-wide road transport model was obtained based on the TD-E survey from 2018. The adequacy of the developed model was assessed based on the results of the General Traffic Measurement from 2015. The obtained model is of satisfactory quality (the coefficient of determination equals 0.62), which can be improved after calibrating the space resistance functions and improving the traffic distribution procedure.
Energy Security as a Premise for Mergers and Acquisitions on the Example of the Multi-Energy Concern PKN Orlen in the Face of the Challenges of the 2020s
Authors: Toborek-Mazur Joanna , Partacz Karol , Surówka Marcin
Published: July 2022

A concern for ensuring energy security is particularly important in the 2020s, a decade significantly marked by economic and political uncertainty: the coronavirus pandemic, the Russian-Ukrainian war, and inflation turning into stagflation in many markets. Additionally, the national and international climate policy promoting the acquisition of energy from non-renewable sources is only a part of the problem that forces a revision of the direction and degree of diversification of energy sources. States, bearing in mind the inevitability of change, in order to maintain energy security, should not only accurately read these phenomena but also effectively prevent them. One of the available solutions is to build a multi-energy concern to ensure energy independence through diversified production and distribution of electricity and non-renewable fuels. To this end, a large international entity centred around the PKN Orlen group has existed in Poland for several years. The construction of this holding is based on M&A transactions, as effective mechanisms for long-term management, and focused around complementary, in terms of economic activity, market entities—Energa, Lotos and PGNiG. This article focuses on the assessment of the phenomenon of capital concentration in M&A transactions by PKN Orlen, with particular emphasis on the changes in the shaping of energy security in the near future and also on the basis of the directions resulting from government guidelines and policies.
End-of-Life Photovoltaic Modules
Authors: Tan Jovan , Jia Shuyue , Ramakrishna Seeram
Published: July 2022

More than 78 million tons of photovoltaic modules (PVMs) will reach their end of life (EOL) by 2050. If they are not responsibly managed, they can (a) pollute our terrestrial ecosystem, (b) indirectly encourage continuous mining and extraction of Earth’s finite resources, and (c) diminish the net environmental benefit of harvesting solar energy. Conversely, successfully recovering them could reduce resource extraction and waste and generate sufficient economic return and value to finance the production of another 2 billion PVMs by 2050. Therefore, EOL PVMs must participate in the circular economy, and business and political leaders are actively devising strategies to enable their participation. This article aims to facilitate and expedite their efforts by comprehensively reviewing and presenting the latest progress and developments in EOL PVM recovery methods and processes. It also identifies and thoroughly discusses several interrelated observations that impede or accelerate their efforts. Overall, our approach to this article differs but synergistically complements and builds upon existing life cycle assessment-based (LCA-based) contributions.
Stomatal Limitation Is Able to Modulate Leaf Coloration Onset of Temperate Deciduous Tree
Authors: Yu Hongying , Zhou Guangsheng , Lv Xiaomin , He Qijin , Zhou Mengzi
Published: July 2022

Autumn phenology, determined mainly by temperature and photoperiod, is essential for ecosystem carbon sequestration. Usually, the variations in the maximum rate of Rubisco (Vcmax) and the maximum rate of ribulose-bisphosphate regeneration (Jmax) are taken as the mechanism regulating the seasonal pattern of photosynthetic rates and autumn phenology. In this study, we used Quercus mongolicus seedlings as an example to examine the photosynthetically physiological mechanism of leaf coloration onset (LCO) responding to different warming and photoperiod treatments based on experimental data acquired from large artificial climate simulation chambers. The results indicated that: (1) LCO and the net CO2 assimilation rate (Pn), transpiration rate (Tr), stomatal conductance (Gs), Vcmax, and Jmax of Quercus mongolicus seedlings were significantly affected by the changes of photoperiod. (2) LCO was significantly correlated only with the Pn approach, supporting the view that leaf senescence is the result of a trade-off between nutrient resorption and reserves. (3) The major variation in stomatal conductance (Gs) is the mechanism by which photoperiod regulates the seasonal pattern of photosynthetic rates, implying that both limitations of stomatal and photosynthetical capacity (Vcmax and Jmax, non-stomatal limitation) are able to modulate LCO. Our study riches the knowledge of phenology and provides a reference for phenological modelling and ecosystem carbon estimation.
Land Surface Temperature Regulation Ecosystem Service: A Case Study of Jaipur, India, and the Urban Island of Jhalana Reserve Forest
Authors: Yosef Reuven , Rakholia Shrey , Mehta Abhinav , Bhatt Alap , Kumbhojkar Swapnil
Published: July 2022

Although Land Surface Temperatures (LSTs) are on the rise globally, the distribution of LSTs varies depending on the land cover type. Urban Heat Island and Urban Cool Island effects act differently, especially in semi-arid regions. Therefore, we identify demi-decadal, seasonal, and zonal differences in LSTs in a semi-arid region in the city of Jaipur, where zones include rural and urban areas that encircle the Jhalana Reserve Forest (JRF). After deriving LSTs from remotely sensed thermal bands of Landsat satellites’ Multi-spectral datasets, we found that there is a significant difference in LST (p < 0.01) among the zones. In addition, LSTs were found to be significantly lower in JRF compared to Urban and Rural areas in all seasons and all study years, which indicates the urban cooling effect due to the presence of the forest. Nevertheless, summer LSTs have warmed with a mean difference of 4.8 °C between 2000 and 2020. Therefore, our study supports the promotion of Urban Forests, especially in semi-arid zones, for inculcating LST regulation ecosystem services to enrich and enhance the standard of living of the human population.
Viscoelasticity-Induced Instability in Plane Couette Flow at Very Low Reynolds Number
Authors: Nimura Tomohiro , Tsukahara Takahiro
Published: July 2022

Elasto-inertial turbulence (EIT), a new turbulent state found in polymer solutions with viscoelastic properties, is associated with drag-reduced turbulence. However, the relationship between EIT and drag-reduced turbulence is not currently well-understood, and it is important to elucidate the mechanism of the transition to EIT. The instability of viscoelastic fluids has been studied in a canonical wall-bounded shear flow to investigate the transition process of EIT. In this study, we numerically deduced that an instability occurs in the linearly stable viscoelastic plane Couette flow for lower Reynolds numbers, at which a non-linear unstable solution exists. Under instability, the flow structure is elongated in the spanwise direction and regularly arranged in the streamwise direction, which is a characteristic structure of EIT. The regularity of the flow structure depends on the Weissenberg number, which represents the strength of elasticity; the structure becomes disordered under high Weissenberg numbers. In the energy spectrum of velocity fluctuations, a steep decay law of the structure’s scale towards a small scale is observed, and this can be recognized as a ubiquitous feature of EIT. The existence of instability in viscoelastic plane Couette flow supports the idea that the transitional path toward EIT may be mediated by subcritical instability.
Adjustable Gel Texture of Recovered Crude Agar Induced by Pressurized Hot Water Treatment of Gelidium sesquipedale Industry Waste Stream: An RSM Analysis
Authors: Diop Cherif Ibrahima Khalil , Beltran Sagrario , Jaime Isabel , Sanz Maria-Teresa
Published: July 2022

A significant amount of bioactive compound-rich solid waste is released during the industrial phycocolloid-centric extraction of Gelidium sesquipedale. The impact of mild pressurized hot water extraction on repurposing this waste for the recovery of agar with an adjustable gel texture is investigated. A two-factor interaction response surface model assessed the influences of the operating temperatures (80 to 130 °C), times (45 and 150 min), pressures (1 to 70 bar), and algae concentrations (3 to 10% (w:v)). At a temperature of 100 °C, a pressure of 10.13 bar, a recovery time of 45 min, and a 10% algae concentration, the working parameters were considered ideal (w:v). Agar with a hardness of 431.6 g, an adhesiveness of −13.14 g.s−1, a springiness of 0.94, a cohesiveness of 0.63, and a gumminess of 274.46 g was produced under these conditions. A combined desirability of 0.78 was obtained for the exposed technology that retrieved gels with a minimum agar yield of 10% and thermal hysteresis between 39 ± 1 and 52 ± 0.5 °C. The fitted design can provide a high techno-commercial value to the agri-food industrial waste stream.