bluuebunny/crossref_metadata_2025 huggingface dataset:
AVANÇOS E DIFICULDADES NA ELABORAÇÃO DE UMA SEQUÊNCIA DIDÁTICA EM APLICATIVO DE REVISÃO ESPAÇADA DE CONCEITOS DE FÍSICA PARA O ENSINO MÉDIO
Authors: Radiske Diego Leonardo Chaves , Vidmar Muryel Pyetro
Published: October 2023

Este trabalho pretende investigar os avanços e obstáculos na elaboração de uma sequência didática para a abordagem de conteúdos de Física para o Ensino Médio a partir da estratégia de revisão espaçada, mediada tecnologicamente por um aplicativo de smartphone. A construção da sequência didática envolveu análise e aprofundamento das potencialidades, possibilidades e limitações associadas à estratégia de revisão espaçada e ao aplicativo Anki, para o Ensino de Física. Foram construídos sessenta cartões no aplicativo Anki para revisão espaçada. Houve obstáculos como o desafio de engajar os alunos no estudo utilizando o smartphone, assim como limitações do Anki que não possibilitam ao professor um acompanhamento aprofundado do desempenho do aluno ou turma. Mas há avanços como as potencialidades do Anki em contribuir para a criação de um hábito de estudo contínuo pelos alunos, favorecer o interesse destes pela aprendizagem, possibilitar múltiplas representações do conhecimento e articular-se com metodologias ativas.
DESIGN-BASED RESEARCH PARA O DESENVOLVIMENOTO DE CONCEITOS MATEMÁTICOS E ATIVAÇÃO DO PENSAMENTO METACOGNITIVO NO ENSINO DE BIOLOGIA
Authors: Reis Erisnaldo Francisco , Strohschoen Andreia Aparecida Guimarães
Published: October 2023

Este artigo se refere aos aspectos da pesquisa que faz parte de uma tese doutoral em que se utilizou a abordagem do Design - Based Research (DBR). Considerando-se os princípios desta metodologia reporta-se acerca do desenvolvimento de um protótipo de Produto Educacional (PE) na forma de Sequência Didática (SD), vinculado à tese de doutoramento do primeiro autor. Assim, o objetivo deste artigo é mostrar como a pesquisa se desenvolveu tomando-se por base a DBR. A partir das informações observadas, pôde-se interpretar o potencial que a metodologia da DBR traz para que sejam idealizadas e construídas propostas de intervenção e melhoramento de aplicações de soluções práticas. Ressalta-se que por se tratar de uma implementação em ambiente de sala de aula real ela ganha a dimensão prática-metodológica, ou seja, traz possibilidade de aproximação da pesquisa dos problemas e necessidade reais dos docentes.
MAPEAMENTO DE PESQUISAS COM ENFOQUE NA APRENDIZAGEM SIGNIFICATIVA E UNIDADES DE ENSINO POTENCIALMENTE SIGNIFICATIVAS DE ÁLGEBRA
Authors: Perceval Valéria Oliveira , Tibulo Vaneza De Carli
Published: October 2023

O presente artigo tem por objetivo apresentar um mapeamento sobre Aprendizagem Significativa e Unidades de Ensino Potencialmente Significativas relacionadas ao ensino de Álgebra a partir das teses e dissertações publicadas no catálogo de tese e dissertações da Capes no período de 2012 a 2021, a fim de analisar os trabalhos relacionados a temática. Como campo de investigação foram utilizados os termos: Álgebra Linear e UEPS; Matrizes e UEPS; Determinantes e UEPS; Sistemas Lineares e UEPS; Álgebra Linear e Aprendizagem Significativa; Matrizes e Aprendizagem Significativa; Determinantes e Aprendizagem Significativa; Sistemas Lineares e Aprendizagem Significativa. Trata-se de uma pesquisa qualitativa de caráter bibliográfico com um corpus de análise constituído por dez pesquisas. Foram elencadas duas categorias de análise, sendo elas: Aspectos teóricos e Aspectos metodológicos. A partir do mapeamento das pesquisas, verifica-se uma concentração de pesquisas na área da Educação Matemática (7) e (4) implementadas na Educação Básica. O principal enfoque, quanto ao conteúdo da pesquisa envolvendo Álgebra e Teoria da Aprendizagem Significativa na Educação Básica, é o de Matrizes. Com base no mapeamento feito foram encontradas poucas pesquisas com enfoque da Teoria da Aprendizagem Significativa e das UEPS envolvendo os conceitos de Álgebra tanto na Educação Básica como no Ensino Superior.
BİREY VE TOPLUM KONULARININ AKTARIMINDA BİR MATERYAL OLARAK EĞİTİCİ ÇİZGİ ROMANLAR
Authors: TOPKAYA Yavuz , KUMRU Selcen , BOZKURT Orçun
Published: October 2023

Toplumların, üyesi olan bireylerde geliştirmeyi amaçladığı nitelikleri öğrenciye kazandırma ile eğitim arasında içli dışlı bir bağ vardır. Bu bağlamda baktığımız zaman eğitim sisteminin parçası olan Sosyal Bilgiler dersi kazanımları ile toplumun istediği donanıma sahip bireyler yetiştirmenin hedeflenmekte olduğu görülmektedir. Bu hedefe ulaşabilme sürecinde ise öğretim ortamları ve materyal varlığı da önemlidir. Bu gerçekten yola çıkarak etkin materyallerden olan çizgi romanın bu hedeflere ulaşma sürecindeki önemi dikkat çekmektedir. Bu araştırmanın temel amacı eğitici çizgi romanın Sosyal Bilgiler dersi kazanımlarının öğrencilere aktarılması sürecinde kullanımı ile ilgili öğrenci görüşlerinin alınmasıdır. Araştırma 2021-2022 eğitim öğretim yılında Hatay Antakya ilçesinde öğrenim gören 20 öğrenci üzerinde gerçekleştirilmiştir. Araştırma nitel yönlü bir çalışma olması açısından araştırmada durum çalışması tekniği tercih edilmiştir. Sosyal Bilgiler dersinde 20 öğrencinin yarı yapılandırılmış mülakat formunda yer alan sorulara yönelik cevapları içerik analizine tabi tutularak incelenmiştir. Araştırma sonucunda ulaşılan veriler ışığında çizgi romanlardaki görsellerin ve diyalogların: Hızlı okuma becerisi kazandırdığı, okuma alışkanlığı kazandırdığı, okuma motivasyonu kazandırdığı, okuduğunu anlama becerisini geliştirdiği, sorun çözme becerisi kazandırdığı, empati kurabilme becerisi kazandırdığı, empatik duyguların önemini ortaya koyduğu, etkin konuşmanın ve etkin dinlemenin önemini kavrattığı, derse aktif katılma oranını arttırdığı, dersi eğlenceli hale getirdiği ve dersi etkili dinleyebilmeyi olumlu etkilediği gibi çıkarımlara ulaşılmıştır.
Analysis of Fishery and Forestry Ventures and Poverty Reduction in Nigeria
Authors: Awujola Abayomi , Obumneke Ezie , Terhemen Nungul Isaac
Published: October 2023

Fishery and forestry ventures are sub-sectors of agriculture with the potential for poverty reduction through employment creation, value addition, and improvement in export earnings. Nevertheless, they have received relatively less attention from all levels of government in Nigeria. This paper examined the effect of fishery and forestry ventures on poverty reduction in Nigeria between 1976 and 2022. Ex-post facto research design was adopted. Data were sourced from CBN annual statistical bulletin, the National Bureau of Statistics, publications of the World Bank, as the Federal Ministry of Agriculture and Rural Development. NARDL was adopted for data analysis. Phillip-Peron Unit root tests revealed a uniform order of integration, while Co-integration Bounds test revealed no existence of long-run relationship between the fishery and forestry ventures and poverty reduction. Findings revealed that agricultural production in fishery and forestry has no significant long-run nexus with poverty reduction in Nigeria. The paper recommended that the Federal Department of Fisheries should engage reputable research institutes and colleges in the fishery industry in Nigeria to train and retrain participants in the sub-sectors to provide skilled workforce in the development of sustainable fishery production towards poverty reduction in Nigeria. The paper also recommended that regulatory agencies in the forestry sub-sector in Nigeria appoint more supervisors and enforcement officers to ensure adequate regulation of the industry towards adding maximum economic value to the exploration and exploitation of the forestry resources in Nigeria by reducing leakages and ensuring that adequate taxes and levies are paid including collection of relevant penalties from defaulters in order to attain sustainable income generation and poverty reduction among the accredited participants.
A Qualitative Exploration of Game-Based Activities in Picture Book Reading: Voices and Practices from Bilingual Kindergartens in China
Authors: Chen Guanzheng
Published: October 2023

This qualitative study delves into the integration of game-based activities within picture book reading sessions in bilingual kindergartens across China. Employing a dual-method approach, data was gathered through semi-structured interviews with six kindergarten teachers and classroom observations by two academic experts. The combined approach ensured a comprehensive understanding of this educational fusion's pedagogical strategies, tangible outcomes, and associated challenges.
The findings highlight educators' ability to align game mechanics with book themes cohesively, consequently amplifying student engagement and comprehension. Challenges surfaced, particularly in aligning games with narrative nuances and managing student competitiveness. Despite the contemporary shift towards technology in Early Foreign Language (EFL) education, the study accentuates the sustained importance of traditional picture book readings, especially when intertwined with interactive games.
This investigation offers a refined lens on EFL pedagogy, underscoring the harmonious integration of modern game-based techniques with core reading practices in bilingual kindergarten settings.
Thermal Performance of Green Roofs in Dry Climate Regions of Mexico through Simulation with Energyplus and Openstudio Tools
Authors: Narváez Gerardo Ashrael Álvarez , Rangel Jaime Moisés Horta , Hernandez Miguel Ángel Pérez Lara y , Zaragoza Juan Bosco Hernández , Rea María Luz Pérez , García Enrique Rico , Lara Teresa López , Gonzalez Eduardo Rojas
Published: October 2023

Place and Duration of Study: Faculty of Engineering, Universidad Autónoma de Querétaro, January 2022 to May 2023.

Green roofs are often used as an aesthetic resource by architecture, since they help to generate artificial green areas in densely populated urban areas, thanks to the fact that they occupy small spaces. This type of system has the quality that it also serves as a passive thermal insulation system. The majority of built green roofs are based on an extensive system, which is characterized by its low maintenance demand and low cost, as it has a shallow substrate and grass-based vegetation. However, in order to exploit the full potential of this system, the optimal parameters for each region must be studied, since the climatological characteristics of the place will directly affect its operation. Through the applied methodology, a base model configured in relation to a system previously established in the Autonomous University of Queretaro (UAQ) was obtained. With the model generated, the relationship between the thickness of the substrate and the decrease in internal temperature was studied, and differences of 5°C were obtained with respect to the external temperature.
Effects of Integrated Weed Management Practices on Weed Parameters and Yield of Bt Cotton (Gossypium hirsutum L.)
Authors: Reddy Vinod , Kulkarni Shyamrao , Chavan Mohan , Ajayakumar M. Y.  , Rudramurthy
Published: October 2023

Aim: To know the effect of integrated weed management on weed parameters and yield of bt cotton.

Study Design: Randomized complete block design.

Place and Duration of Study: College of Agriculture Farm, Bheemaraynagudi between July 2021 and Feb 2022.

Methodology: The field experiment was conducted during Kharif 2021 at Experimental block, College of Agriculture, Bheemarayanagudi. The soil of the experiment field was deep black clayey in texture. The experiment comprises 11 weed management practices viz., T1: Pendimethalin 38.7% CS @ 750 g a.i./ha as PE + Hand weeding @ 20-25 DAS and Intercultivation @ 55-60 DAS, T2: Pendimethalin 38.7 % CS @ 750 g a.i./ha as PE fb Pyrithiobac Sodium 10 EC @ 75g a.i./ha + Quizalofop ethyl 5 EC @ 37.5g a.i./ha as PoE @ 25 DAS and Intercultivation @ 55-60 DAS. (Tank mix), T3 : Pendimethalin 38.7 % CS @ 750 g a.i./ha as PE fb Pyrithiobac Sodium 10 EC @ 50g a.i./ha + Quizalofop ethyl 5 EC @ 25 g a.i./ha as PoE @ 25 DAS and Intercultivation @ 55-60 DAS, T4 :Pendimethalin 38.7 % CS @ 750 g a.i./ha as PE fb Pyrithiobac Sodium 10 EC @ 75g a.i./ha + Quizalofop ethyl 5 EC @ 37.5g a.i./ha as PoE @ 25 DAS and Intercultivation @ 55-60 DAS, T5 : Pendimethalin 38.7 % CS @ 750 g a.i./ha as PE fb Pyrithiobac Sodium 10 EC @ 100g a.i./ha + Quizalofop ethyl 5 EC @ 50g a.i./ha as PoE @ 25 DAS and Intercultivation @ 55-60 DAS, T6 : Pyrithiobac Sodium 10 EC @ 50g a.i./ha + Quizalofop ethyl 5 EC @ 25g a.i./ha as PoE @ 25 DAS and Intercultivation @ 55-60 DAS, T7: Pyrithiobac Sodium 10 EC @ 75g a.i./ha + Quizalofop ethyl 5 EC @ 37.5g a.i./ha as PoE @ 25 DAS and Intercultivation @ 55-60 DAS, T8: Pyrithiobac Sodium 10 EC @ 100g a.i./ha + Quizalofop ethyl 5 EC @ 50g a.i./ha as PoE @ 25 DAS and Intercultivation @ 55-60 DAS, T9: Farmers practice (Hand weeding @ 25 DAS and 2 intercultivations @ 50 and 75 DAS), T10: Weedy check, T11: Weed free check.

Results: Among the treatments, application of pendimethalin 38.7 % CS @ 750 g a.i./ha as PE fb pyrithiobac sodium 10 EC @ 100 g a.i./ha + quizalofop ethyl 5 EC @ 50 g a.i./ha as PoE (combi-product) @ 25 DAS and intercultivation @ 55-60 DAS recorded significantly lower weed density and higher weed control efficiency (82.39 %), also recorded higher seed cotton yield (2495 kg ha-1) and stalk yield (4056 kg ha-1) over other treatments.

Conclusion: Application of Pendimethalin 38.7 % CS @ 750 g a.i./ha as PE fb Pyrithiobac Sodium 10 EC @ 100g a.i./ha + Quizalofop ethyl 5 EC @ 50g a.i./ha as PoE @ 25 DAS and Intercultivation @ 55-60 DAS was found effective in controlling the weeds with coupled with higher seed cotton yield .
Impacts of Climate Change on Fruit Crops: A Comprehensive Review of Physiological, Phenological, and Pest-Related Responses
Authors: Yadav Shubham , Korat J. R. , Yadav Sanjeev , Mondal Kabita , Kumar Anuj , Homeshvari  , Kumar Suneel
Published: October 2023

This review paper comprehensively examines the multifaceted effects of climate change on fruit crops, delving into physiological, phenological, and pest-related responses. Climate change, characterized by shifts in temperature, precipitation patterns, and extreme events, presents profound challenges to fruit crop cultivation and production. By analyzing the interplay between climate variations and fruit crops' physiological processes, flowering patterns, and susceptibility to pests, this paper aims to provide a comprehensive understanding of the intricate mechanisms underlying these interactions. The study encompasses the influence of drought, rainfall, temperature fluctuations, and pest dynamics on various fruit crops, ranging from mangoes and apples to bananas, grapes, and more. The review underscores the urgency of developing adaptive strategies to mitigate the adverse impacts of climate change on fruit crop production and quality.
Population Dynamics of the Coriander Aphids in Hyper Arid Region of Rajasthan and their Correlation with Biotic and Abiotic Factors
Authors: Kumar Vijay , Deshwal H. L. , Mahendra  , Gurjar Manoj Kumar , Kumawat Rohit
Published: October 2023

Population dynamics of coriander aphid and their correlation with biotic and abiotic factors were studied at instructional farm of the department of Entomology, College of Agriculture, SKRAU Bikaner during Rabi, 2020-21 and 2021-22. The incidence of coriander aphid, H. coriandri (Das) commenced in the fourth week of January (4th SMW) and remained active throughout the crop season i.e. upto third week of March during both the years (2020-21 and 2021-22). The population of H. coriandri increased gradually and attained its peak in last week of February/first week of March (9th SMW) during both the years. After peak aphid population started declining and reached to low levels in the 11th SMW near maturity of the crop during both the years. Simultaneously the occurrence of predator, Coccinella septempunctata coincided with the population of aphids during both the years. Maximum and minimum temperatures had positive correlation with aphid population during both the years i.e. 2020-21, 2021-22. Morning and evening relative humidity showed negative correlation with aphid population. whereas, population of C. septempunctata was significant positively correlated with aphid population during both years.
In-vivo Screening of Cherry Tomato [Solanum lycopersicum L. var. cerasiforme (Dunnal) A. Gray] Genotypes and Hybrids against Fusarium Wilt in Arunachal Pradesh, India
Authors: Dutta Rituraj , Bhutia Nangsol Dolma , Raja P. , Singh Siddhartha , Hazarika Budhindra Nath , Deo Chandra , Rozerto Khwairakpam , Yumkhaibam Tabalique , Yumkhaibam Pravinkumar
Published: October 2023

Cherry tomato [Solanum lycopersicum L. var. cerasiforme (Dunnal) A. Gray] is becoming popular among various tribes of Arunachal Pradesh due to its unique taste, flavor and appearance. Owing high rainfall and high humidity, successful cultivation of cherry tomato is becoming restricted in this state due to various biotic factors like infection of wilt complexes as well as pests like root-knot nematodes. The aim of the present investigation was to evaluate eighteen cherry tomato genotypes (nine) and hybrids (nine) against Fungal wilt caused by Fusarium oxysporum f. sp. lycopersici resistance in the Pasighat condition of Arunachal Pradesh, India. For screening purpose, artificial pathogen inoculation method was applied through pin-prick method in the 35 days old cherry tomato seedlings that were grown in pot culture containing sterile soil and data for the pathogen infection was recorded by following Completely Randomized Design (CRD) in 60 days and 120 days after pathogen inoculation. Among 18 genotypes and hybrids, G4xG6 (DI:0.00%, PDI:0.00%), G9 (DI:0.00%, PDI:0.00%) and G5 (DI:0.00%, PDI:0.00%) showed highest resistance towards Fusarium wilt, while genotype G3 (DI:65.56%, PDI:63.60%) exhibited susceptible system. The disease incidence was ranged from 0.00%-65.56%. The use of resistant genotypes and hybrids to manage the population of fungus is a very cost effective method and can be exploited commercially in breeding programmes and for vegetable grafting.
A Review of Long-Term Effects of Mineral Fertilizers on Soil Microorganisms
Authors: Verma Rajesh Chandra , Singh N. K. , Gangavati Anuradha Ravindra , Ashoka P.  , Kesarwani Amit , Ali Insha , Pandey Shivam Kumar , Singh Bal veer
Published: October 2023

The intricate relationship between soil microbiomes and fertilizers is central to the sustainable future of agriculture. This review delves deep into the multifaceted interactions between soil microorganisms and varying fertilizer regimens, shedding light on their immediate and long-term impacts. Soil, teeming with a rich diversity of bacteria, fungi, archaea, protozoa, and viruses, plays a pivotal role in agricultural productivity. These microbial communities are intricately linked to soil health, fertility, and resilience. Fertilizers, while essential for enhancing crop yields, have shown varied impacts on these microbial communities. Immediate post-application dynamics reveal shifts in microbial diversity and abundance, with potential cascading effects on soil processes. Longitudinal studies in real-world agricultural settings underscore the resilience and adaptability of these communities in the face of disturbances. Advanced technological tools, from metagenomics to IoT devices, offer unprecedented insights and real-time monitoring capabilities. The convergence of biology with technology holds the promise of a future where agricultural practices are fine-tuned based on real-time microbial feedback, ensuring both enhanced yields and sustained soil health. As we stand at the crossroads of a global food demand surge and environmental sustainability, understanding and harnessing the potential of soil microbiomes becomes paramount. This review underscores the need for robust, long-term research endeavors to chart a path for truly sustainable agriculture.
Genetic Variability and Correlation Studies for Yield and Yield Related Traits in Rice (Oryza sativa L.)
Authors: Madishetty Amulya Rani , Lal Gaibriyal M. , Adarsh K.
Published: October 2023

The study aims to estimate the genetic parameters of 13 yield-attributing traits to study Genetic Variability and Correlation studies for yield and yield-related traits in rice. The investigation comprised of 20 Rice genotypes used for the experiment carried out during Kharif- 2022 in Randomized Block Design with three replications at the field Experimentation Center, Department of Genetics and Plant Breeding, Sam Higginbottom University of Agriculture Technology and Sciences, Prayagraj (Allahabad), India. The greater  value of the phenotypic coefficient of variation (PCV) compared to the corresponding genotypic coefficient of variation (GCV) for all the studied traits indicated that there was an influence of the environment on biological yield per plant, Grain yield per plant, and test weight. All of the traits had high heritability, indicating that direct selection of these characters based on phenotypic expression using a simple selection procedure for yield improvement would be more accurate.  Grain yield per plant showed a significant and positive association with biological yield, panicle length, no of spikelets per panicle, plant height, test weight, flag leaf width, and days to maturity indicating selection of these characteristics for yield improvement may be rewarding. Both at phenotype and genotype levels Biological yield per plant, panicle length, no of spikelets per panicle, plant height, test weight, days to flowering, days to maturity, and flag leaf width had positive direct effects on grain yield per plant indicating their importance during selection in the yield improvement program. Furthermore, the data gained by this study can be used in future rice breeding programs.
Effect of Inorganic Fertilizers and Biogas Slurry on Content and Uptake of NPK in Wheat Grown under Sodic Vertisols
Authors: Vishwakarma Megha , Bangre Jyoti , Khandkar U. R. , Tiwari S. C. , Vishwakarma Mahima
Published: October 2023

Conjoint use of inorganic and organic amendments can be a pragmatic solution for improving soil physico-chemical and biological properties and sustaining crop productivity. Keeping in this view a pot experiment was conducted during rabi season of 2015-16 in net house of AICRP on Management of Salt Affected soils and use of Saline Water in Agriculture, College of Agriculture, Indore to study the effect of recommended doses of fertilizer and biogas slurry on uptake and content of NPK in wheat grown under sodic Vertisols. The treatment comprised of T0-Control, T1-100% RDF, T2- 100% RDF + 750 kg BGS ha-1, T3-75% RDF + 750 kg BGS ha-1, T4- 50% RDF + 750 kg BGS ha-1, T5- 100% RDF + 1000 kg BGS ha-1, T6-75% RDF + 1000 kg BGS ha-1, T7-50% RDF + 1000 kg BGS ha-1, T8-100% RDF + 1250 kg BGS ha-1, T9-75% RDF+ 1250 kg BGS ha-1, T10-50% RDF+ 1250 kg BGS ha-1 were laid in completely randomized design with 3 replications. Results showed that the treatment T9 (75% RDF+1250 kg BGS ha-1) gave maximum dry matter production (0.205, 0.434 and 0.821 g plant-1, respectively), N content (2.39, 1.58 and 1.36% respectively), P content (0.41, 0.30 and 0.24%, respectively) and K content (1.24, 0.68 and 1.68%, respectively) in wheat leaf at 30, 60 and 90 DAS. Maximum uptake of N (1.20 and 0.72 g pot-1, respectively), P (0.132 and 0.119 g pot-1, respectively) and K (0.237 and 1.08 g pot-1, respectively) by grain and straw of wheat respectively, were found with the application of T9 (75% RDF+1250 kg BGS ha-1). Thus, it may be concluded that integrated application of T9 (75% RDF+1250 kg BGS  ha-1) not only increases dry matter production but also content and uptake by wheat.
From Bench to Bedside: A Scoping Review of Gene Therapy Approaches in the Management of Cardiomyopathies
Authors: Gopal Shwetha , Imtiaz Zainab , Ijishakin Olumide , Louise-Oluwasanmi Olusayo , Berhe Helen Surafeal , Emmanuel Ogunniyi Kayode , Oni Efe , Agbo Gift Joanna , Gabriel Kareeba Leefoon , Ezeamii Victor Chiedozie , Omole Janet , Okunzuwa Efe , Amiruddin Aaquib Syed , Okunromade Omolola , Rayapati Lakshmi Tulasi
Published: October 2023

Background: Cardiomyopathies represent a heterogeneous group of heart muscle diseases with diverse etiologies. With the advent of molecular biology and genetic engineering, novel therapeutic strategies are being developed and explored to target the genetic basis of these diseases.

Methods: A scoping review was performed of studies published between 2017 and 2023, exploring gene-based therapeutic interventions for various forms of cardiomyopathies. Literature was selected from a wide range of international databases, including PubMed, EMBASE, and Web of Science, with selection criteria focused on the application of gene therapies in preclinical and clinical studies.

Findings: A total of 9 studies were included in the review, revealing various gene therapy strategies, including antisense therapies, gene editing, miRNA manipulation, and the use of gene therapy vectors for targeted treatment. Although most of the studies were conducted in preclinical models, they exhibited promising outcomes such as improved cardiac function, reduced fibrosis, and amelioration of disease phenotype. The review also highlighted the considerable heterogeneity among studies in terms of the disease models used, targeted genes, and measured outcomes, indicating the complexity of the field.

Conclusion: This scoping review presents an overview of the emerging gene therapy strategies for cardiomyopathies, revealing promising outcomes in preclinical models. However, several challenges remain, including the translation of findings from animal models to humans, ethical considerations, and potential disparities in access to these treatments. Future research should focus on addressing these challenges to pave the way for innovative, efficacious, and accessible therapies for patients with cardiomyopathies.
Synthetic Cooling Agent and Other Flavor Additives in “Non-Menthol” Cigarettes Marketed in California and Massachusetts After Menthol Cigarette Bans
Authors: Jabba Sairam V. , Erythropel Hanno C. , Anastas Paul T. , Zimmerman Julie B. , Jordt Sven E.
Published: October 2023

This study uses a bioassay and chemical analysis to determine the proportion of newly introduced “non-menthol” cigarette brands with sensory cooling effects, cooling agents added, and any other flavor additives after menthol cigarette bans.
Amyloid Positron Emission Tomography and Subsequent Health Care Use Among Medicare Beneficiaries With Mild Cognitive Impairment or Dementia
Authors: Rabinovici Gil D. , Carrillo Maria C. , Apgar Charles , Gareen Ilana F. , Gutman Roee , Hanna Lucy , Hillner Bruce E. , March Andrew , Romanoff Justin , Siegel Barry A. , Smith Karen , Song Yunjie , Weber Christopher , Whitmer Rachel A. , Gatsonis Constantine
Published: October 2023

Importance

Results of amyloid positron emission tomography (PET) have been shown to change the management of patients with mild cognitive impairment (MCI) or dementia who meet Appropriate Use Criteria (AUC).

Objective

To determine if amyloid PET is associated with reduced hospitalizations and emergency department (ED) visits over 12 months in patients with MCI or dementia.

Design, Setting, and Participants

This nonrandomized controlled trial analyzed participants in the Imaging Dementia–Evidence for Amyloid Scanning (IDEAS) study, an open-label, multisite, longitudinal study that enrolled participants between February 2016 and December 2017 and followed up through December 2018. These participants were recruited at 595 clinical sites that provide specialty memory care across the US. Eligible participants were Medicare beneficiaries 65 years or older with a diagnosis of MCI or dementia within the past 24 months who met published AUC for amyloid PET. Each IDEAS study participant was matched to a control Medicare beneficiary who had not undergone amyloid PET. Data analysis was conducted on December 13, 2022.

Exposure

Participants underwent amyloid PET at imaging centers.

Main Outcomes and Measures

The primary end points were the proportions of patients with 12-month inpatient hospital admissions and ED visits. One of 4 secondary end points was the rate of hospitalizations and rate of ED visits in participants with positive vs negative amyloid PET results. Health care use was ascertained from Medicare claims data.

Results

The 2 cohorts (IDEAS study participants and controls) each comprised 12 684 adults, including 6467 females (51.0%) with a median (IQR) age of 77 (73-81) years. Over 12 months, 24.0% of the IDEAS study participants were hospitalized, compared with 25.1% of the matched control cohort, for a relative reduction of −4.49% (97.5% CI, −9.09% to 0.34%). The 12-month ED visit rates were nearly identical between the 2 cohorts (44.8% in both IDEAS study and control cohorts) for a relative reduction of −0.12% (97.5% CI, −3.19% to 3.05%). Both outcomes fell short of the prespecified effect size of 10% or greater relative reduction. Overall, 1467 of 6848 participants (21.4%) with positive amyloid PET scans were hospitalized within 12 months compared with 1081 of 4209 participants (25.7%) with negative amyloid PET scans (adjusted odds ratio, 0.83; 95% CI, 0.78-0.89).

Conclusions and Relevance

Results of this nonrandomized controlled trial showed that use of amyloid PET was not associated with a significant reduction in 12-month hospitalizations or ED visits. Rates of hospitalization were lower in patients with positive vs negative amyloid PET results.
Antibiotic Use Among Infants Admitted to Neonatal Intensive Care Units
Authors: Flannery Dustin D. , Zevallos Barboza Alvaro , Mukhopadhyay Sagori , Wade Kelly C. , Gerber Jeffrey S. , Shu Di , Puopolo Karen M.
Published: October 2023

This cross-sectional study examines antibiotic exposure, days of therapy, types of antibiotics, and changes in use patterns among newborns in neonatal intensive care units (NICUs) across the US from 2009 to 2021.
Strength of bolted steel structural members under eccentric tension
Authors: Nagasato Kazuma , Ikarashi Kikuo , Mitsui Kazuya
Published: October 2023

The effective cross‐sectional area method for the outstanding leg is utilized as an ineffective area to evaluate the strength in the present Japanese design standard. Given that this evaluation method is fundamentally premised on experimental outcomes derived from relatively thick plates, it must be extended to brace members composed of thin plates. In this study, we conduct bolt joint experiments and numerical analyses on thin‐plate angles and channel members, with the aim to elucidate the elements influencing the efficiency of the joint. We propose a unified bolt joint strength evaluation formula that also considers thin‐plate members.
High‐resolution MR neurography follow‐up of SARS‐CoV‐2 vaccination‐associated neuralgic amyotrophy
Authors: Mooshage Christoph M. , Kele Henrich , Bendszus Martin , Schwarz Daniel
Published: October 2023

Little is known about the value of high‐resolution follow‐up imaging in patients with neuralgic amyotrophy (NA) and the question of the best treatment algorithm remains unclear. Three patients (one female, two male) with the clinical presentation of SARS‐CoV‐2‐vaccination‐associated NA underwent initial magnetic resonance neurography (MRN) imaging and follow‐up examinations. All patients showed a marked clinical improvement, independent of treatment, including an almost full recovery of motor function over the course of 8–12 months which was accurately mirrored by imaging findings on MRN. MRN imaging is a valuable tool for monitoring the further clinical course of patients suffering from vaccination‐associated NA.
First‐Principles Design of Alloy Systems, Part I: Effects of Solute Type, Concentration, and Distribution on Alloying and Mechanical Properties – As‐Quenched Dilute Al (Mg, Si) Alloys
Authors: Samiee Alireza , Shahmiri Reza , Sorrell Charles Christophesr
Published: October 2023

Solid solution strengthening is a well‐known strengthening mechanism for Al (Mg, Si) alloys. The distribution of solute atoms plays an important role in the enhancement of the mechanical properties. As‐quenched, dilute, Al alloys are analysed by atom probe tomography (APT) and mechanical testing (microhardness, tensile testing) and these data have been employed in order to assess the 3D distribution of solute atoms in the solid solutions. An innovative approach is to abstain from the conventional logic of binary versus ternary alloys in data analysis in favor of a less‐concentrated versus more‐concentrated strategy. This approach enables for the first time that the integration of first‐principles Condon–Morse atomic interaction effects, APT, and mechanical testing, and first principles effects (field, proximity, chemical, and atomic size), which results in a novel empirical singleton‐cluster plot. The plot allows differentiation between singletons, solute clusters, and coclusters as well as between the less‐concentrated and more‐concentrated alloys. The plot also allows determination of the maximal yield strengths from cluster strengthening and from singletons in the absence of clustering. Most critically, this new approach in data analysis allows for the first time the determination of the dmax (maximal distance between solutes in a cluster) based on experimental results.
Radioiodine‐131‐Labeled Theranostic Nanoparticles for Transarterial Radioembolization and Chemoembolization Combination Therapy of VX2 Liver Tumor
Authors: Jia Guorong , Wang Tao , Li Rou , Li Xiao , Sun Gaofeng , Chen Wei , Peng Ye , Cheng Chao , Yang Jijin , Zuo Changjing
Published: October 2023

In interventional treatment, materials are administered into the blood supply artery and directly delivered to tumors, offering proper scenarios for nanomedicine potential clinical applications. Transarterial chemoembolization (TACE) and transarterial radioembolization (TARE) are effective treatment methods for hepatocellular carcinoma (HCC), but postoperative residual tumor may result in intrahepatic recurrence and distant metastasis. The combination therapy of TACE and TARE based on multifunctional nanoparticles (NPs) is expected to overcome the drug resistance in hypoxic tumors and improve the therapeutic effect. Herein, BaGdF5 NPs are synthesized and then coated with polydopamine (PDA), conjugated with the chemotherapeutic drug cis‐diamminedichloride platinum (CDDP), radio‐labeled with therapeutic radionuclide 131I, yielding 131I‐BaGdF5@PDA‐CDDP NPs. The in vitro anti‐cancer effects of 131I‐BaGdF5@PDA‐CDDP NPs are confirmed using CCK‐8 and γ‐H2AX assays in Huh7 cells. Mixed with Lipiodol, 131I‐BaGdF5@PDA‐CDDP NPs are injected into the hepatic artery via a microcatheter to realize the TACE and TARE combination therapy in a rabbit VX2 liver tumor model. The results indicate that glucose metabolism is clearly decreased based on 18F‐FDG PET imaging and the apoptosis of tumor cells is increased. Furthermore, 131I and BaGdF5 NPs can be used for SPECT imaging and CT/MR imaging respectively, facilitating real‐time monitoring of the in vivo biodistribution of 131I‐BaGdF5@PDA‐CDDP NPs.
Zwitterion‐conjugated Topological Glycomimics for Dual‐Blocking Effects to Eradicate Biofilm Infection
Authors: Guo Qianqian , Cheng Yijie , Fan Zheng , Wu Weihui , Wu Zhongming , Zhang Xinge
Published: October 2023

P. aeruginosa, a leading nosocomial pathogen, commonly causes chronic biofilm infections in tissues and biomedical devices, including wound infections, osteomyelitis, and infective endocarditis, heavily threatening life. The dynamic lifecycle of these biofilms leads to persistent generation, making it challenging to prevent and disperse these biofilms effectively. Herein, a topological eight‐arm zwitterion‐conjugated glycomimetics (PCBAA‐b‐PLAMA)8 to address this challenge by exerting a dual‐blocking effect on P. aeruginosa biofilms is introduced. Initially, carboxybetaine acrylate (CBAA) and 2‐lactobionamidoethyl methacrylate (LAMA) are introduced to the topological bromine‐based initiator to prepare (PCBAA‐b‐PLAMA)8. This copolymer demonstrats remarkable efficiency in dispersing P. aeruginosa biofilms, approximately up to 99%. This high efficacy can be attributed to the multivalent and triaxial interactions between LAMA and CBAA groups, which enable the capture of P. aeruginosa cells and the biofilm matrix. Furthermore, (PCBAA‐b‐PLAMA)8 efficiently inhibit the expression of resistance genes related to biofilm formation and antibiotic efflux, including cdrA, lasB, mexE, and mexH, regaining bacterial cell sensitivity to antibiotics and further facilitating the natural dispersal of biofilms. This study provides a generic dual‐blocking strategy for the efficient eliminating of biofilms from biomedical devices.
Genome‐wide association analysis of coleoptile length and interaction with plant height in durum wheat
Authors: Sesiz Uğur , Alsaleh Ahmad , Bektas Harun , Topu Mustafa , Özkan Hakan
Published: October 2023

Genotypes with longer coleoptiles can be sown in deep soil layers to reach the underground moisture needed for germination in dry areas. Developing new varieties with longer coleoptiles and shorter plant heights would be novel for wheat breeding and production. In this study, coleoptile lengths of a panel of durum wheat (Triticum turgidum ssp. durum) genotypes were determined, and 14,255 DArTseq (SNP and Silico‐DArT) markers were used to identify coleoptile length‐associated markers by genome‐wide association study (GWAS). A wide genetic variation was accounted for both coleoptile length and plant height. The genetic relationships between coleoptile length and plant height were evaluated using plant height values from five different environments. Two environmentally stable MTAs were identified, one for coleoptile length (QCol.su.4BS) and one for plant height (QPh.su.4BS). These MTAs were located on the short arm of chromosome 4B, with LOD scores up to 12.00 and 17.00, respectively. A relatively high LD (r2 = 0.71) was accounted for between QCol.su.4BS and QPh.su.4BS. The LD block intervals of the MTAs overlapped with some genes with roles in plant growth and development. The functions of plausible candidate genes tell us that QCol.su.4BS may be controlling coleoptile length, whereas QPh.su.4BS may be regulating plant height. The combination of the two loci would be desirable. In conclusion, this study sheds light on the genetic control of coleoptile length and its relationship with plant height in durum wheat.
A matching‐adjusted indirect comparison of acalabrutinib versus zanubrutinib in relapsed or refractory chronic lymphocytic leukemia
Authors: Kittai Adam S. , Skarbnik Alan , Miranda Miguel , Yong Alan S. M. , Roos Jack , Hettle Robert , Palazuelos‐Munoz Sarah , Shetty Vikram , Ghia Paolo
Published: October 2023

Video Abstract
Recent Discovery, Development, and Synthetic Applications of Formic Acid Salts in Photochemistry
Authors: Majhi Jadab , Molander Gary A.
Published: October 2023

The advancement of sustainable photoredox catalysis in synthetic organic chemistry has evolved immensely because of the development of versatile and cost‐effective reagents. In recent years, a substantial effort has been dedicated to exploring the utility of formic acid salts in various photochemical reactions. In this context, formates have demonstrated diverse capabilities, functioning as reductants, sources of carbonyl groups, and reagents for hydrogen atom transfer. Notably, the CO2⋅– radical anion derived from formate exhibits strong reductant properties for cleaving both C−X and C−O bonds. Moreover, these salts play a pivotal role in carboxylation reactions, further highlighting their significance in a variety of photochemical transformations. The ability of formates to serve as reductants, carbonyl sources, and hydrogen atom transfer reagents reveal exciting possibilities in synthetic organic chemistry. This minireview highlights an array of captivating discoveries, underscoring the crucial role of formates in diverse and distinctive photochemical methods, enabling access to a wide range of value‐added compounds.
Thiophene π‐bridge‐based second near‐infrared luminogens with aggregation‐induced emission for biomedical applications
Authors: Tan Yonghong , Sun Yan , Huang Weigeng , Zhu Dongxia , Yan Dingyuan , Wang Dong , Tang Ben Zhong
Published: October 2023

In the past 5 years, aggregation‐induced emission luminogens (AIEgens) with emission in the second near‐infrared (NIR‐II) optical window have aroused great interest in bioimaging and disease phototheranostics, benefiting from the merits of deep penetration depth, reduced light scatting, high spatial resolution, and minimal photodamage. To construct NIR‐II AIEgens, thiophene derivatives are frequently adopted as π‐bridge by virtue of their electron‐rich feature and good modifiability. Herein, we summarize the recent progress of NIR‐II AIEgens by employing thiophene derivatives as π‐bridge mainly compassing unsubstituted thiophene, alkyl thiophene, 3,4‐ethylenedioxythiophene, and benzo[c]thiophene, with a discussion on their structure–property relationships and biomedical applications. Finally, a brief conclusion and perspective on this fascinating area are offered.
Readability and content gaps in online epilepsy surgery materials as potential health literacy and shared‐decision‐making barriers
Authors: Seneviratne Namal U. , Ho Sophey Y. , Boro Alexis , Correa Daniel J.
Published: October 2023

Objective

Epilepsy surgery is an effective albeit underused treatment for refractory epilepsy, and online materials are vital to patient understanding of the complex process. Our goal is to analyze the readability and content inclusion of online patient health education materials designed for epilepsy surgery.

Methods

A private browser setting was used on Google and Bing to identify the top 100 search results for the terms “epilepsy+surgery”. Scientific papers, insurance pages, pay‐wall access sites, and non‐text content were excluded. The website text was reformatted to exclude graphics, contact information, links, and headers. Readability metrics were calculated using an online tool. Text content was analyzed for inclusion of important concepts (pre‐surgical evaluation, complications, risks of continued seizures, types of surgery, complimentary diagrams/audiovisual material). Comparison of readability and content inclusion was performed as a function of organization types (epilepsy center, community health organization, pediatric‐specific) and location (region, country).

Results

Browser search yielded 82 distinct websites with information regarding epilepsy surgery, with 98.7% of websites exceeding the recommended 6th‐grade reading level for health information. Epilepsy centers had significantly worse readability (Flesch–Kincaid Grade Level (FKGL) P < 0.01 and Flesch Reading Ease (FRE) P < 0.05). Content analysis showed that only 37% of websites discuss surgical side effects and only 23% mention the risks of continued seizures. Epilepsy centers were less likely to report information on surgical side effects (P < 0.001). UK‐based websites had better readability (FKGL P < 0.01 and FRE P < 0.01) and were more likely to discuss side effects (P = 0.01) compared to US‐based websites.

Significance

The majority of online health content is overly complex and relatively incomplete in multiple key areas important to health literacy and understanding of surgical candidacy. Our findings suggest academic organizations, including level 4 epilepsy centers, need to simplify and broaden online education resources. More comprehensive, publicly accessible, and readable information may lead to better‐shared decision‐making.
Reconnecting with the Warrior Within: Australian Indigenous perspectives on the development of a social and emotional wellbeing program
Authors: Hodgkinson Luke , Bowman Sarah , Blunden Sarah
Published: October 2023

Issue Addressed

Australian Indigenous youth are at high risk of developing mental health problems. Historical determinants and socioeconomic disadvantage continue to impact their social and emotional wellbeing (SEWB) and sense of identity. Previous literature suggests connecting to culture significantly impacts SEWB in Indigenous youth. Given the diversity of Indigenous culture, collaboration and consultation with specific cultural groups is required to develop appropriate and relevant psychological treatments for SEWB. The Warrior Within Program was developed to improve SEWB in Indigenous youth by assisting them to better understand their identity through participation in group‐based cultural activities. This research aimed to understand Central Queensland Indigenous Development staff perspectives around (1) the process of developing the program and (2) how group‐based cultural activities contributed to staff perceived improvements in SEWB of program participants.

Methods

In this qualitative study, semi‐structured individual interviews of 60–90 min were conducted with four Warrior Within Program staff of Central Queensland Indigenous Development. Transcripts were thematically analysed and the subthemes identified were categorised into main themes.

Results

The process of developing the Warrior Within Program, cultural and Indigenous identity, reconnecting and knowledge emerged as the four main themes.

Conclusions

This study makes a unique and important contribution to the Australian Indigenous literature regarding the role and nature of culture in group‐based programs and the importance of collaborating with Indigenous groups to increase our understanding of their usefulness and efficacy. This study also helps to bridge the gap between Indigenous ways of knowing in program development and non‐Indigenous methods of evaluation.

So What?

Acknowledging Australian Indigenous methods and ways of knowing are essential to the development and delivery of culturally appropriate group problems for addressing the psychological needs of this population. The methods used in this study could be used by others seeking to legitimise cultural ways of knowing.
Recent advances in treatment technology of wastewater containing H‐acid: a mini‐review
Authors: Cao Yongjun , Hong Qing , Zhang Yuanjian
Published: October 2023

H‐acid, a prevalent pollutant in dyeing wastewater, is primarily utilized in the pharmaceutical and textile industries. However, H‐acid treatment remains a challenge because of its high concentration, degradation resistance and poor biodegradability. This review examines the principles, characteristics, advantages and disadvantages of the most recently developed advanced practical H‐acid treatment technologies. Furthermore, this review analyzes the existing issues within these methods and explores potential future development trends. © 2023 Society of Chemical Industry.