bluuebunny/crossref_metadata_2025 huggingface dataset:
Historical aspects and modern approaches to recording lower jaw movements
Authors:   Lviv National Medical University named after Danylo Halytskyi, Lviv, Ukraine, Makeyev V. , Shybinska M. ,   Lviv National Medical University named after Danylo Halytskyi, Lviv, Ukraine
Published: October 2024

Objective: To systematize and review available scientific research data over twenty years regarding systems and methods for recording lower jaw movements. Materials and Methods: A literature search was conducted on the PubMed service. Publications up to 2024 were considered. The primary filter in the search system was used to select publications based on the following criteria: metaanalysis, review, systematic review. Only publications in English were selected for the initial data set. The primary search yielded 45 publications. After a detailed analysis of the selected publications, 35 publications that best met the needs were retained for further processing. Additionally, 3 publications from other services that addressed the topic were added manually. Thus, the total number of publications used for the analysis amounted to 37 articles. Results: The analysis of lower jaw movements provides the clinician with important parameters for evaluating the function of the temporomandibular joint (TMJ). These parameters are crucial for modeling the normal functioning of the masticatory apparatus. Therefore, in-depth knowledge of lower jaw movements is necessary for dentists of various profiles, especially prosthodontists and orthodontists. Familiarity with various methods used to measure lower jaw movements is key in clinical analysis. The hardware for recording lower jaw movements has evolved significantly from purely mechanical methods to modern electronic systems with multi-functional software, ensuring high-level functional rehabilitation of the dentoalveolar system. Key words: lower jaw, temporomandibular joint, function, registration of lower jaw movements, hardware.
TRABALHO INTERPROFISSIONAL COM ADOLESCENTES DO PROGRAMA FORÇAS NO ESPORTE (PROFESP)
Authors: Batista Aline , Luz Tolosa Vitória , Machado Luz Ferreira Ana Paula , Dornelles Saleh Flavia , Gargaro Zamarchi Thiago , Menezes Seerig Lenise
Published: October 2024

A promoção da saúde é vista como uma estratégia eficaz para abordar diferentes problemas de saúde em crianças, uma vez que as atividades educativas visam mudar o comportamento individual. O objetivo deste trabalho é relatar a experiência de um grupo de crianças e adolescentes integrantes de um projeto social. A metodologia de trabalho foi pesquisa-ação e teve caráter interprofissional, envolvendo psicologia e odontologia, desenvolvendo os pilares de ensino, pesquisa e extensão. As acadêmicas dos cursos de enfermagem, psicologia e odontologia organizaram as atividades para dois encontros, através de cartazes educativos e explicativos sobre temas de saúde (cuidados no ambiente familiar, alimentação saudável, higiene bucal e corporal). Foram 2 encontros no mês de junho de 2023, e cerca de 100 crianças em cada dia participaram desta ação no PROFESP. Foi possível perceber que as atividades estimularam as crianças e os adolescentes a dialogarem e expressarem valores, opiniões, sofrimentos, preocupações, situações pessoais e perceber o contexto no qual estavam inseridos. Houve promoção de diálogo sobre os fatores de risco à saúde e autocuidado, além de oportunizar troca de experiências e esclarecimento de dúvidas. No início, os participantes pareciam receosos, mas curiosos e atentos às atividades, além de demonstrarem interesse nos assuntos abordados e a vontade aparente de continuar aprofundando-os. Considera-se que foi possível perceber o funcionamento coletivo das crianças e adolescentes e as dinâmicas advindas do próprio lugar e do grupo específico.
Comparison of Breast Sensibility Following Breast Reconstruction with Two Different Techniques: Deep Inferior Epigastric Perforator Flap and Implant
Authors: Tazi Soraya
Published: October 2024

Introduction: Breast sensibility following reconstruction surgery, though often overlooked, holds significant importance due to its widespread occurrence and profound effects on patients’ well-being and safety. The author’s objective is to compare the sensory outcomes between deep inferior epigastric perforator (DIEP) flap microsurgery reconstruction and implant-based reconstruction. Additionally, the potential influence of sociodemographic and clinical factors on sensory recovery is explored, along with assessing temperature discrimination abilities and evaluating quality of life.

Material and methods: An ambispective descriptive-analytical study was conducted involving women who underwent mastectomy with reconstruction using either DIEP flap and implants at the author’s hospital between 1990–2021. Data were collected from medical records, patient histories, physical examinations, and validated quality of life questionnaires (BREAST-Q). Spearman’s or Pearson’s correlation coefficients were employed for the analysis of quantitative variables, while the Student’s T test or Mann-Whitney U test were used to compare quantitative and qualitative variables.

Results: A total of 99 women with breast reconstruction were included, 47 with DIEP flap and 52 with implants. Sensory recovery in implant-based reconstruction was found to be superior to DIEP flap reconstruction (5.03 and 5.18, respectively; p<0.005). A direct correlation was observed between sensory improvement and thermal discrimination (Spearman coefficient 0.9; p<0.001). Factors such as radiotherapy, delayed reconstruction with DIEP flap, and height with implants were associated with poorer sensory recovery in the breast. Women experiencing better breast sensibility reported higher satisfaction with their surgeon, medical team, and psychosocial quality of life.

Conclusion: Women reconstructed with implants or DIEP abdominal flap exhibit suboptimal overall sensory recovery of the reconstructed breast, with slightly better outcomes observed in women reconstructed with implants. The development of novel surgical techniques aimed at enhancing sensibility after breast reconstruction could significantly benefit these patients.
Hukuk Felsefesi Öğretiminde Edebiyat Eserleri
Authors: Akı E. İrem
Published: October 2024

Edebiyat eserleri hem Türkiye’nin hem de Dünya’nın çeşitli üniversitelerinde Hukuk ve Edebiyat dersleri aracılığıyla hukuk eğitiminde yer almaktadır. Bu makalede edebiyat eserlerinin hukuk felsefesi dersinde kullanımının dersin işleyişine nasıl bir katkı sunacağı üzerinde durulacaktır. Edebiyat eserleri hukuk felsefesi dersinde ne işe yarar? Edebiyat eserleri aracılığıyla hukuk felsefesi dersinde veremediğimiz neyi veririz öğrenciye? Bu soruları yanıtlamak için birinci bölümde hukuk felsefesinin hukuk eğitimindeki yeri ortaya koyulacak, ikinci bölümde hukuk felsefesi alanındaki gelişmeler ışığında Hukuk ve Edebiyat akımının ortaya çıkışı üzerinde durulacak ve üçüncü bölümde de hukuk felsefesi öğretiminde, edebiyatta hukuk yaklaşımı çerçevesinde, alternatif bir yöntem olarak edebiyat eserlerinin ne tür olanaklar sağlayabileceği tartışılacak ve edebiyat eserlerinin hukuk felsefesi öğretimi için üç olanak sunduğu iddia edilecektir. Buna göre ilk olarak edebiyat eserleri adalet, sosyal adalet, önyargılar, otorite, hukuka bağlılık gibi belirli kavramları tartışmak; ikinci olarak hukukçunun önemli bir işi olan kişilerin eylemlerini belirli bir bağlam içinde görmek ve değerlendirmek; üçüncü olarak da kişilerin eylemlerini değerlendirirken veya yargılarken önyargıların nasıl adaletsiz durumlara yol açtığını göstermek bakımından zengin kaynaklardır. Makalenin son bölümünde de Necip Fazıl Kısakürek’in Reis Bey oyunu üzerinden önyargılar ve yarattıkları adaletsiz durumlar tartışılacaktır.
Cultural implications of the liberties and guarantees bourn of Magna Carta
Authors: Wakefield, Ph.D. Mark J. R.
Published: October 2024

This text seeks to trace a broad outline of the circumstances under which the Magna Carta was originally conceived in England in the early 13th century. It also aims to identify the forces and inspiration that drove those who conceived of its form and imposition to act in the manner they and the legacy it has had on ensuing generations. While the great charter was not always fully respected, it did enjoy a revival owing to the scholarly diligence of Sir Edward Coke and this initiative paved the way for its permanent fixture as part of the architecture of liberty in England and the settlers of the American colonies who took inspiration from it. Attention is also given to the fundamental role played by rhetorical discourse in the advancement and preservation of the spirit of freedom originally inspired by content of the original charter.
Marka İmajının Satın Alma Niyeti Üzerindeki Etkisi: Iğdır İli Z Kuşağı Tüketicileri Üzerine Bir Çalışma
Authors: Soyuk Seccad
Published: October 2024

Bu çalışmanın amacı Z kuşağı bireylerinin marka imajı algılarının satın alma davranışı üzerindeki etkisini ölçmeye yöneliktir. Şimdiye kadar var olan kuşaklardan ayrı olarak iletişim, telekomünikasyon ve teknoloji dünyası ile birlikte doğan Z kuşağı, geleceğin tüketici adayları olmalarından dolayı alışveriş alışkanlıklarının ve satın alma karar tarzlarının incelenmesi marka ve firmalar açısından büyük önem taşımaktadır. Bu sebeple araştırmanın amacı, hazır giyim sektörünün önemli bir potansiyeli olan Z kuşağının tüketici davranışlarının incelenmesi şeklinde belirlenmiştir. Araştırma Iğdır ilinde Google form üzerinden çevrim içi anket yöntemi ile toplam 552 katılımcı üzerinde gerçekleştirilmiştir. Araştırma kapsamında toplanan veriler SPPS 20 paket programı ile geçerlilik, güvenirlik, farklılık analizleri ve YEM Amos 21 paket programı ile yapısal eşitlik modellemesi, korelasyon ve yol analizleri yapılmıştır. Araştırma sonuçlarına göre bir markanın imaj düzeyi güçlendikçe tüketicilerin o markaya karşı satın alma davranışlarının pozitif yönlü artış gösterdiği tespit edilmiştir. Analiz sonuçları incelendiğinde bekâr ve kadın katılımcıların evli katılımcılara göre gider düzeylerinin daha düşük olması nedeniyle tercih ettikleri markaların imaj düzeylerinden etkilendikleri ve buna bağlı olarak satın alma düzeylerinin yüksek olduğu belirlenmiştir. Araştırma kapsamında elde edilen bir başka sonuç ise bireylerin gelirleri arttıkça marka imajı eğilimleri yükselmekte ve markaya karşı olan eğilimleri artmaktadır. Ayrıca demografik değişkenler açısından bireylerin satın alma tutumlarının etkilendiği sonucuna ulaşılmıştır. Araştırmada elde edilen bir diğer sonuca göre ise katılımcıların (n=552, %79,5’i) marka tercihlerinde reklamların bir etkisinin olmadığını belirtmişlerdir. Ulaşılan bu sonuçlara dayanarak firmaların pazarlama operasyonlarında geleneksel pazarlama yöntemleri yerine modern pazarlama yöntemlerini uygulamaları önerilmektedir.
Bibliometric Analysis of Studies on the Concept of Fear of Missing Out with VOSviewer
Authors: Ayaz Esra
Published: October 2024

This study aims to map the existing lietrature on the conept of fear of missing out. Within the scope of quantitative data in the study, it is aimed to examine the existing literature on the concept of fear of missing out, which has become one of the main problems of our age, using bibliometric analysis. The unit of analysis is based on the bibliometric data of various types of studies scanned in the Web of Science database and published between 2013 and 2023. When we look at the distribution of 648 studies on Fear of Missing Out according to the years of publication, we see that there is the highest concentration in 2023 (148 studies) and 2022 (134 studies), the most cited researchers are Andrew K. Przybylski, Kou Murayama, Cody R. DeHaan, and Valerie Gladwell. The type of publication is mostly journal articles (563), the fields of research are psychology (264), business economics (88), computer science (51) and social sciences (30), and there are more publications indexed in SSCI (468), SCI (185) and ESCI (114).
Analisis Validitas Instrumen Lembar Kerja Peserta Didik Bermuatan Nilai-Nilai Islam Berbasis Problem Based Learning Pada Materi Himpunan Kelas VII
Authors: Rahmawati Novia , Iesyah Rodliyah
Published: October 2024

Pendidikan merupakan sebuah kebutuhan yang utama bagi tiap manusia. Salah satu ilmu pengetahuan yang penting dalam kemajuan proses berfikir serta mampu menyelesaikan masalah didalam  kehidupan sehari-hari adalah matematika. Masih banyak peserta didik dikalangan pesantren yang masih membeda-bedakan antara pelajaran agama dengan pelajaran umum khususnya matematika. Penelitian ini bertujuan untuk menghasilkan media pembelajaran berupa LKPD bermuatan nilai-nilai Islam berbasis masalah pembelajaran materi himpunan. Artikel ini adalah bagian dari penelitian besar pada pengembangan media pembelajaran dengan model ADDIE. Metode penelitian ini adalah Research and Development dengan model pengembangan ADDIE. Langkah yang dilakukan hanya tahap 1 sampai 3 yaitu analisis, perancangan dan pengembangan. Hasil validasi dari dosen memperoleh hasil rata-rata 83,3% dengan kriteria sangat valid dan hasil validasi dari guru mendapatkan hasil rata-rata 82,5% dengan kriteria sangat valid. Hasil rata-rata validasi dari kedua validator adalah 82,9% dengan kriteria sangat valid.
PENGARUH MODEL PEMBELAJARAN KOOPERATIF TIPE STAD TERHADAP HASIL BELAJAR MATEMATIKA SISWA
Authors: Ikhsan Muhammad Maulana , Nihayatus Sa’adah
Published: October 2024

Penelitian ini bertujuan untuk mendeskripsikan ada atau tidaknya pengaruh pembelajaran kooperatif tipa STAD terhadap hasil belajar siswa .Jenis penelitian ini ialah pendekatan kuantitatif Dengan mengunakan desain penelitian posttest control grup design. Populasi ialah siswa kelas VIII yang berjumlah 192 siswa. Sampel yang digunakan adalah peserta didik kelas VIII-A yang berjumlah 32 orang sebagai kelas eksperimen dan peserta didik kelas VIII-D yang berjumlah 32 orang sebagai kelas kontrol. Teknik pengambilan sampel dengan menggunakan purposive sample. Data diperoleh melalui posttest kemudian dianalisis menggunakan uji t-test. Data tes akhir kelas sampel dianalisis menggunakan uji-t. Hasil uji-t diperoleh nilai signifikansi < taraf signifikansi dapat diketahui nilai signifikansi (2-tailed) adalah 0.000 artinya < 0.05. Berdasarkan hipotesis yang diajukan terdapat pengaruh model pembelajaran kooperatif tipe STAD terhadap hasil belajar siswa kleas VIII MTsN 12 Jombang.
Laser-induced graphene gas sensors for environmental monitoring
Authors: Francis Cadré , Rektor Attila , Valayil-Varghese Tony , McKibben Nicholas , Estrada Isaac , Forbey Jennifer , Estrada David
Published: October 2024

Artemesia tridentata is a foundational plant taxon in western North America and an important medicinal plant threatened by climate change. Low-cost fabrication of sensors is critical for developing large-area sensor networks for understanding and monitoring a range of environmental conditions. However, the availability of materials and manufacturing processes is still in the early stages, limiting the capacity to develop cost-effective sensors at a large scale. In this study, we demonstrate the fabrication of low-cost flexible sensors using laser-induced graphene (LIG); a graphitic material synthesized using a 450-nm wavelength bench top laser patterned onto polyimide substrates. We demonstrate the effect of the intensity and focus of the incident beam on the morphology and electrical properties of the synthesized material. Raman analyses of the synthesized LIG show a defect-rich graphene with a crystallite size in the tens of nanometers. This shows that the high level of disorder within the LIG structure, along with the porous nature of the material provide a good surface for gas adsorption. The initial characterization of the material has shown an analyte response represented by a change in resistance of up to 5% in the presence of volatile organic compounds (VOCs) that are emitted and detected by Artemisia species. Bend testing up to 100 cycles provides evidence that these sensors will remain resilient when deployed across the landscapes to assess VOC signaling in plant communities. The versatile low-cost laser writing technique highlights the promise of low-cost and scalable fabrication of LIG sensors for gas sensor monitoring.
Pathogen spectrum and microbiome in lower respiratory tract of patients with different pulmonary diseases based on metagenomic next-generation sequencing
Authors: Hong Rujun , Lin Sheng , Zhang Siting , Yi Yaxing , Li Lanfeng , Yang Haitao , Du Zhenshan , Cao Xuefang , Wu Wenjie , Ren Ruotong , Yao Xiujuan , Xie Baosong
Published: October 2024

Introduction

The homeostasis of the microbiome in lower respiratory tract is crucial in sustaining normal physiological functions of the lung. Different pulmonary diseases display varying degrees of microbiome imbalance; however, the specific variability and clinical significance of their microbiomes remain largely unexplored.

Methods

In this study, we delineated the pathogen spectrum and commensal microorganisms in the lower respiratory tract of various pulmonary diseases using metagenomic sequencing. We analyzed the disparities and commonalities of the microbial features and examined their correlation with disease characteristics.

Results

We observed distinct pathogen profiles and a diversity in lower airway microbiome in patients diagnosed with cancer, interstitial lung disease, bronchiectasis, common pneumonia, Nontuberculous mycobacteria (NTM) pneumonia, and severe pneumonia.

Discussion

This study illustrates the utility of Metagenomic Next-generation Sequencing (mNGS) in identifying pathogens and analyzing the lower respiratory microbiome, which is important for understanding the microbiological aspect of pulmonary diseases and essential for their early and precise diagnosis.
Future directions for deep ocean climate science and evidence-based decision making
Authors: Pillar Helen R. , Hetherington Elizabeth , Levin Lisa A. , Cimoli Laura , Lauderdale Jonathan M. , van der Grient Jesse M. A. , Johannes Kristen , Heimbach Patrick , Smith Leslie , Addey Charles I. , Annasawmy Pavanee , Antonio Sandra , Bax Narissa , Drake Henri F. , Escobar Elva , Elsler Laura G. , Freilich Mara A. , Gallo Natalya D. , Girard Fanny , Harke Matthew J. , Jones Daniel O. B. , Joshi Siddhi , Liang Xinfeng , Maroni Paige J. , Sarti Otmane , Stefanoudis Paris V. , Sulpis Olivier , Trossman David
Published: October 2024

Introduction

A defining aspect of the Intergovernmental Panel on Climate Change (IPCC) assessment reports (AR) is a formal uncertainty language framework that emphasizes higher certainty issues across the reports, especially in the executive summaries and short summaries for policymakers. As a result, potentially significant risks involving understudied components of the climate system are shielded from view.

Methods

Here we seek to address this in the latest, sixth assessment report (AR6) for one such component—the deep ocean—by summarizing major uncertainties (based on discussions of low confidence issues or gaps) regarding its role in our changing climate system. The goal is to identify key research priorities to improve IPCC confidence levels in deep ocean systems and facilitate the dissemination of IPCC results regarding potentially high impact deep ocean processes to decision-makers. This will accelerate improvement of global climate projections and aid in informing efforts to mitigate climate change impacts. An analysis of 3,000 pages across the six selected AR6 reports revealed 219 major science gaps related to the deep ocean. These were categorized by climate stressor and nature of impacts.

Results

Half of these are biological science gaps, primarily surrounding our understanding of changes in ocean ecosystems, fisheries, and primary productivity. The remaining science gaps are related to uncertainties in the physical (32%) and biogeochemical (15%) ocean states and processes. Model deficiencies are the leading cited cause of low certainty in the physical ocean and ice states, whereas causes of biological uncertainties are most often attributed to limited studies and observations or conflicting results.

Discussion

Key areas for coordinated effort within the deep ocean observing and modeling community have emerged, which will improve confidence in the deep ocean state and its ongoing changes for the next assessment report. This list of key “known unknowns” includes meridional overturning circulation, ocean deoxygenation and acidification, primary production, food supply and the ocean carbon cycle, climate change impacts on ocean ecosystems and fisheries, and ocean-based climate interventions. From these findings, we offer recommendations for AR7 to avoid omitting low confidence-high risk changes in the climate system.
Investigating the metabolomic pathways in female reproductive endocrine disorders: a Mendelian randomization study
Authors: Lu Fei-fan , Wang Zheng , Yang Qian-qian , Yan Feng-shang , Xu Chang , Wang Ming-tang , Xu Zhu-jing , Cai Sheng-yun , Guan Rui
Published: October 2024

Introduction

Reproductive endocrine disorders (RED), including polycystic ovary syndrome (PCOS), endometriosis (EMs), and female infertility (FI), significantly affect women’s health globally, with varying prevalence across different regions. These conditions can be addressed through medication, surgical interventions, and lifestyle modifications. However, the limited understanding of RED’s etiology and the substantial economic burden of its treatment highlight the importance of investigating its pathogenesis. Metabolites play a critical role in metabolic processes and are potentially linked to the development of RED. Despite existing studies suggesting correlations between metabolites and RED, conclusive evidence remains scarce, primarily due to the observational nature of these studies, which are prone to confounding factors.

Methods

This study utilized Mendelian Randomization (MR) to explore the causal relationship between metabolites and RED, leveraging genetic variants associated with metabolite levels as instrumental variables to minimize confounding and reverse causality. Data were obtained from the Metabolomics GWAS Server and the IEU OpenGWAS project. Instrumental variables were selected based on their association with the human gut microbiota composition, and the GWAS summary statistics for metabolites, PCOS, EMs, and FI were analyzed. The MR-Egger regression and random-effects inverse-variance weighted (IVW) methods were employed to validate the causal relationship. Cochran’s Q test was employed to evaluate heterogeneity, sensitivity analysis was performed using leave-one-out analysis, and for pleiotropy analysis, the intercept term of MR-Egger’s method was investigated.

Results

The MR analysis revealed significant associations between various metabolites and RED conditions. For instance, a positive association was found between 1-palmitoylglycerophosphocholine and PCOS, while a negative association was noted between phenylacetate and FI. The study identified several metabolites associated with an increased risk and others with protective effects against PCOS, EMs, and FI. These findings highlight the complex interplay between metabolites and RED, suggesting potential pathways through which these conditions could be influenced or treated.

Conclusion

This MR study provides valuable insights into the causal relationship between metabolites and female reproductive endocrine disorders, suggesting that metabolic alterations play a significant role in the pathogenesis of PCOS, EMs, and FI, and offering a foundation for future research and therapeutic development.
Clinical features of pituitary carcinoma: analysis based on a case report and literature review
Authors: Yang Yongxiang , Liang Wanlin , Fan Kexia , Yang Tao , Cheng Jingmin
Published: October 2024

Introduction

Pituitary carcinoma (PC) is an extremely rare tumor of the adenohypophysis, which manifests as craniospinal dissemination and/or systemic metastasis. The diagnosis of PC is particularly difficult, as the clinical diagnosis only can be made after the metastasis is found. Owing to the complex diagnostic process and less effective treatments, the clinical prognosis of PC is usually very poor. Hence, it is of great significance to illustrate the diagnosis and treatment course of PC.

Methods

In this case report, we described a 48-year-old male patient who was diagnosed with pituitary adenoma (PA) initially and then was diagnosed with PC eventually after spinal cord metastasis was found, and we illustrated the treatment course as well. Furthermore, we summarized all the published case reports until now and provided a comprehensive review of the diagnosis, treatment, prediction, and clinical outcome of PC.

Results and Conclusions

We found that most PC patients had adrenocorticotropic hormone/prolactin (ACTH/PRL)-secreting tumors, Ki-67 ≥ 10%, and P53 positivity, which may have the potential to predict the transformation from PA to PC; surgery excision combined with temozolomide (TMZ) and radiotherapy is helpful to prolong the survival of PC patients.
MMP-9 as a clinical marker for endometriosis: a meta-analysis and bioinformatics analysis
Authors: Huang Qiumei , Song Yanlun , Lei Xiaocan , Huang Hua , Nong Weihua
Published: October 2024

Aim

This study systematically evaluated the potential efficacy of serum matrix metalloproteinase-9 (MMP-9) concentration as a diagnostic marker for endometriosis through meta-analysis. Early and accurate diagnosis of endometriosis, a common gynecological disease, is crucial for improving patient prognosis. Hence, this study aimed to comprehensively analyze the data from multiple studies to assess the diagnostic value of serum MMP-9 concentration for endometriosis.

Methods

Articles investigating the association between MMP-9 and endometriosis, published from the inception of the databases until February 2024, were systematically retrieved from multiple databases, including PubMed, Embase, Cochrane, Web of Science, Scopus, and CNKI. Download and analyze the GSE7305, GSE23339, and GSE51981 datasets. Statistical analyses of all eligible studies were conducted using RevMan 5.4, Stata 11.0, and R software version 4.3.3.

Results

Fifteen studies fully met the inclusion criteria for the meta-analysis. The concentration of MMP-9 in the blood of patients with endometriosis was significantly higher compared to that of the control group (p < 0.0001). Subgroup analysis based on different stages of endometriosis revealed a trend towards significantly higher serum MMP-9 concentrations in patients, whether in stages I-II or III-IV. Bioinformatics analysis revealed differences in the expression of MMP-9 in endometrial tissue between EMT patients and healthy controls in the GSE7305 and GSE23339 datasets. Additionally, in the GSE51981 dataset, we found significant differences between the normal group and both mild and severe cases of endometriosis.

Conclusion

Both the current meta-analysis and bioinformatics analysis indicate differences in MMP-9 concentration levels between endometriosis patients and healthy individuals, with potentially elevated MMP-9 concentrations in serum samples from patients with endometriosis.

Systematic review registration

https://www.crd.york.ac.uk/prospero, identifier CRD42024525864.
Paternal behaviour is associated with high levels of OT in plasma and the presence OTR in the mPOA/BNST in the Mongolian gerbil (Meriones unguiculatus)
Authors: Romero-Morales Luis , García-Saucedo Brenda , Carmona Agustín , Cervantes Fernando A. , Luis Juana
Published: October 2024

The exhibition of paternal behaviour has been associated with high peripheral concentrations of oxytocin (OT) and levels of oxytocin receptors (OTRs) in the paraventricular and supraoptic nuclei of the hypothalamus. The presence of OTRs in the medial preoptic area (mPOA), bed nucleus of the stria terminalis (BNST), medial amygdala (MeA), and olfactory bulb (OB) has not been studied extensively in the paternal context, although these nuclei are essential in the regulation of paternal behaviour. The aim of this study was to determine whether there is an association between paternal response of sexually inexperienced males of the Mongolian gerbils (Meriones unguiculatus) and OT concentrations in plasma, as well as the presence of OTRs in the mPOA, BNST, MeA, and OB. We used sexually inexperienced gerbils: ten paternal (PAT) males and 10 males aggressive with pups (AGG). PAT males and AGG males were subjected to paternal behaviour tests. Then, blood samples were taken to quantify OT concentrations. The brains were dissected for OTR immunohistochemistry analyses. PAT males had significantly higher plasma levels of OT and numbers of cells with OTR immunoreactivity (ir) in the mPOA/BNST. These results indicated an association between paternal behaviour and peripheral concentrations of OT, as well as the presence of OTRs in the mPOA and BNST. This suggests that OT and OTRs could participate in the regulation of paternal behaviour in the Mongolian gerbil.
Exome sequencing data reanalysis of 200 hypertrophic cardiomyopathy patients: the HYPERGEN French cohort 5 years after the initial analysis
Authors: Jaouadi Hager , Morel Victor , Martel Helene , Lindenbaum Pierre , de la Chapelle Lorcan Lamy , Herbane Marine , Lucas Claire , Magdinier Frédérique , Gilbert Habib , Schott Jean-Jacques , Zaffran Stéphane , Nguyen Karine
Published: October 2024

Background

Approximately half of hypertrophic cardiomyopathy (HCM) patients lack a precise genetic diagnosis. The likelihood of identifying clinically relevant variants increased over time.

Methods

In this study, we conducted a gene-centric reanalysis of exome data of 200 HCM cases 5 years after the initial analysis. This reanalysis prioritized genes with a matched HCM entry in the OMIM database and recently emerging HCM-associated genes gathered using a text mining-based literature review. Further classification of the identified genes and variants was performed using the Clinical Genome Resource (ClinGen) resource and American College of Medical Genetics and Genomics (ACMG) guidelines to assess the robustness of gene–disease association and the clinical actionability of the prioritized variants.

Results

As expected, the majority of patients carried variants in MYBPC3 and MYH7 genes, 26% (n = 51) and 8% (n = 16), respectively, in accordance with the initial analysis. The vast majority of pathogenic (P) and likely pathogenic (LP) variants were found in MYBPC3 (22 out of 40 variants) and MYH7 (8 out of 16 variants) genes. Three genes—not included in the initial analysis—were identified: SVIL, FHOD3, and TRIM63. Considering only patients with unique variants in the last three genes, there was a 9% enhancement in variant identification. Importantly, SVIL variant carriers presented apical and septal HCM, aortopathies, and severe scoliosis for one patient. Ten patients (5%) carried variants in the FHOD3 gene, six in hotspot regions (exons 12 and 15). We identified seven variants within the TRIM63 gene in 12 patients (6%). Homozygous variants were detected in 2.5% of the cohort in MYBPC3 (n = 1), MYL3 (n = 1), and TRIM63 (n = 3) genes.

Conclusion

Our study revealed that no variants were found in the ACTC1, TPM1, and TNNI3 genes in the HYPERGEN cohort. However, we identified variants in five out of the eight HCM core genes, with a high prevalence in young patients. We identified variants in three recent HCM-associated genes (SVIL, FHOD3, and TRIM63) in 35 patients, with 18 patients carrying unique variants (9%). Our results further emphasize the usefulness of exome data reanalysis, particularly in genotype-negative patients.
Caregivers in implantable brain-computer interface research: a scoping review
Authors: Wohns Nicolai , Dorfman Natalie , Klein Eran
Published: October 2024

Introduction

While the ethical significance of caregivers in neurological research has increasingly been recognized, the role of caregivers in brain-computer interface (BCI) research has received relatively less attention.

Objectives

This report investigates the extent to which caregivers are mentioned in publications describing implantable BCI (iBCI) research for individuals with motor dysfunction, communication impairment, and blindness.

Methods

The scoping review was conducted in June 2024 using the PubMed and Web of Science bibliographic databases. The articles were systematically searched using query terms for caregivers, family members, and guardians, and the results were quantitatively and qualitatively analyzed.

Results

Our search yielded 315 unique studies, 78 of which were included in this scoping review. Thirty-four (43.6%) of the 78 articles mentioned the study participant’s caregivers. We sorted these into 5 categories: Twenty-two (64.7%) of the 34 articles thanked caregivers in the acknowledgement section, 6 (17.6%) articles described the caregiver’s role with regard to the consent process, 12 (35.3%) described the caregiver’s role in the technical maintenance and upkeep of the BCI system or in other procedural aspects of the study, 9 (26.5%) discussed how the BCI enhanced participant communication and goal-directed behavior with the help of a caregiver, and 3 (8.8%) articles included general comments that did not fit into the other categories but still related to the importance of caregivers in the lives of the research participants.

Discussion

Caregivers were mentioned in less than half of BCI studies in this review. The studies that offered more robust discussions of caregivers provide valuable insight into the integral role that caregivers play in supporting the study participants and the research process. Attention to the role of caregivers in successful BCI research studies can help guide the responsible development of future BCI study protocols.
Enhancement sensitivity of TRPV1 in dorsal root ganglia via the SP-NK-1 pathway contributes to increased bladder organ sensitivity caused by prostatitis
Authors: Jiang ZhiPeng , Luo Wen , Liu Lei , Long ZongMin
Published: October 2024

Chronic prostatitis/chronic pelvic pain syndrome is a prevalent condition affecting the male urinary system. The urinary dysfunction resulting from this disorder has a direct or indirect impact on the patient’s quality of life. Recent studies have suggested that organ cross-sensitization between the prostate and bladder may elucidate this phenomenon; however, the specific molecular mechanisms remain unclear. In this study, we simulated the urinary symptoms of prostatitis patients using an animal model and examined the expression of relevant proteins within the prostate-bladder sensitized neural pathway. We found that transient receptor potential vanilloid 1 (TRPV1) protein is highly expressed in the dorsal root ganglia (DRG) that co-innervate both the prostate and bladder, potentially increasing the sensitivity of TRPV1 channels via the substance P-neurokinin 1 (SP-NK-1) pathway, which may exacerbate micturition symptoms. Furthermore, in the absence of bladder inflammation, elevated levels of neurogenic substances in bladder tissue were found to sensitize bladder sensory afferents. Collectively, these results underscore the significant role of TRPV1 in bladder sensitization associated with prostatitis, suggesting that the inhibition of TRPV1 along this sensitization pathway could be a promising approach to treating urinary dysfunction linked to prostatitis in the future.
Prevalence of anhedonia, anxiety, and their impact on food consumption among postgraduate Qassim University students
Authors: Alrehaili Sarah , Afifi Abeer A. , Algheshairy Reham M. , Bushnaq Taqwa , Alharbi Talal Ali F. , Alharbi Hend F.
Published: October 2024

Objectives

A prevalent symptom of many mental health issues, such as depression, is anhedonia, which is the inability to feel joy or pleasure. Tension-induced sensations, anxious thoughts, and bodily alterations are the hallmarks of anxiety. One known environmental factor that affects mental health is diet. In this implication, eating appetizing meals has been proposed to reduce unpleasant feelings like worry. This study aimed to indicate whether eating habits among postgraduate students are related to symptoms of anhedonia and/or anxiety.

Methods

In a cross-sectional study, responses were collected from a total of 393 postgraduate students. Each student self-answered the General Anxiety Disorder-7, Snaith-Hamilton Pleasure Scale for Anhedonia, and the Food Consumption Questionnaire and reported the body weight.

Results

The prevalence of anhedonia was 28%, moderate anxiety and severe anxiety were 15.7 and 10.9%, respectively. In this research, results showed that sugary foods, fast food, and fried foods were positively associated with anxiety and anhedonia. However, fruits and vegetables were negatively associated with anxiety and anhedonia. Linear regression showed that fruit and drinking water consumption was significant with the number of meals/day. There was no significance between the number of meals per day and anhedonia; however, there was statistical significance with the total GAD-7 scale score regarding the number of meals/per day.

Conclusion

Anhedonia and anxiety are associated with food consumption, especially foods rich in sugars, fast and fried, which help to increase positive feelings. Future studies should focus on understanding the relationship between food consumption and following a healthy diet and improving and reducing symptoms of anxiety and anhedonia in those who suffer from a stressful or task-filled lifestyle, such as students, especially postgraduate students. In addition, it focuses on the importance of awareness of the symptoms of anhedonia, which is classified as a depressive disease, and how to control anxiety to maintain better mental health.
Education and metabolic syndrome: a Mendelian randomization study
Authors: Liu Dong , Xu Zi-Xiang , Liu Xue-lian , Yang Hai-Ling , Wang Ling-ling , Li Yan
Published: October 2024

Aims

The metabolic syndrome (MetS), a collection of conditions that heighten the risk of disease development and impose economic burdens on patients. However, the causal relationship between education and MetS was uncertain. In this study, the Mendelian randomization (MR) method was employed to elucidate the potential causal link between education and the MetS and its components.

Method

Single nucleotide polymorphisms (SNPs) associated with education, MetS, and its components were sourced from a public database, with the inverse variance-weighted (IVW) method utilized for analysis.

Results

Education demonstrated a significant negative correlation with the risk of MetS (OR = 0.55, 95% CI = 0.48–0.63, p = 2.18E−51), waist circumference(OR = 0.80, 95% CI = 0.76–0.83, p = 4.98E-33), hypertension (OR = 0.96, 95% CI = 0.95–0.97; p = 4.54E-10), Fasting blood glucose (OR = 0.94, 95% CI = 0.91–0.97, p = 7.58E-6) and triglycerides (OR = 0.83, 95% CI = 0.79–0.87, p = 7.87E-18) while showing a positive association with high-density lipoprotein cholesterol (OR = 1.22, 95% CI = 1.18–1.25, p = 1.45E-31).

Conclusion

The findings of this study suggest that education can decrease the incidence of MetS.
Modulating the gut microbiota in Crohn’s disease: a pilot study on the impact of a plant-based diet with DNA-based monitoring
Authors: Østergaard Stine Karstenskov , Cetin Zeynep , Rasmussen Henrik Højgaard , Lærke Helle Nygaard , Holst Mette , Lauridsen Charlotte , Nielsen Jeppe Lund
Published: October 2024

Introduction

Crohn’s Disease (CD) is characterized by chronic intestinal inflammation and dysbiosis. This study aimed to investigate the effects of a plant-based diet (PBD) on gut microbiota composition and inflammation in CD patients and assess the utility of trnL gene sequencing for monitoring dietary adherence.

Methods

Fourteen CD patients participated in a 12-week PBD intervention. Dietary adherence was monitored through self-reported food diaries and trnL sequencing, which detects plant residues in fecal samples. Gut microbiota was analyzed using 16S rRNA sequencing, and fecal calprotectin levels were measured as an indicator of intestinal inflammation.

Results

TrnL sequencing identified 55 plant genera in fecal samples, compared to 41 reported in food diaries, highlighting its accuracy in assessing plant residue diversity. By week 4, participants demonstrated a 1.4-fold increase in plant intake, correlating with a significant increase in microbial diversity. Key genera associated with gut health, such as Faecalibacterium and Bacteroides, increased in abundance. Additionally, fecal calprotectin levels decreased from 472 mg/kg at baseline to 207 mg/kg at week 12, indicating reduced intestinal inflammation.

Discussion

A PBD positively influenced gut microbiota composition and decreased intestinal inflammation in CD patients. The study also demonstrated that trnL sequencing is an effective tool for assessing dietary adherence in clinical settings, offering a more objective measure than self-reported food diaries.
The intricate interplay between ferroptosis and efferocytosis in cancer: unraveling novel insights and therapeutic opportunities
Authors: Firouzjaei Ali Ahmadizad , Mohammadi-Yeganeh Samira
Published: October 2024

The complex interplay between ferroptosis and efferocytosis in cancer has attracted significant interest recently. Efferocytosis, the process of eliminating apoptotic cells, is essential for preserving tissue homeostasis and reducing inflammation. However, dysregulation of efferocytosis can have profound effects on cancer. Apoptotic cells accumulate because of impaired efferocytosis, which triggers chronic inflammation and the release of pro-inflammatory chemicals. Surprisingly, accumulating evidence suggests that dysregulation of ferroptosis- a form of controlled cell death characterized by lipid peroxidation and the buildup iron-dependent reactive oxygen species (ROS)-can influence efferocytic activities within the tumor microenvironment. Dysfunctional iron metabolism and increased lipid peroxidation, are associated with ferroptosis, resulting in inadequate apoptotic cell clearance. Conversely, apoptotic cells can activate ferroptotic pathways, increasing oxidative stress and inducing cell death in cancer cells. This reciprocal interaction emphasizes the complex relationship between efferocytosis and ferroptosis in cancer biology. Understanding and managing the delicate balance between cell clearance and cell death pathways holds significant therapeutic potential in cancer treatment. Targeting the efferocytosis and ferroptosis pathways may offer new opportunities for improving tumor clearance, reducing inflammation, and sensitizing cancer cells to therapeutic interventions. Further research into the interaction between efferocytosis and ferroptosis in cancer will provide valuable insights for the development of novel therapies aimed at restoring tissue homeostasis and improving patient outcomes.
LCGSC-YOLO: a lightweight apple leaf diseases detection method based on LCNet and GSConv module under YOLO framework
Authors: Wang Jianlong , Qin Congcong , Hou Beibei , Yuan Yuan , Zhang Yake , Feng Wenfeng
Published: October 2024

Introduction

In response to the current mainstream deep learning detection methods with a large number of learned parameters and the complexity of apple leaf disease scenarios, the paper proposes a lightweight method and names it LCGSC-YOLO. This method is based on the LCNet(A Lightweight CPU Convolutional Neural Network) and GSConv(Group Shuffle Convolution) module modified YOLO(You Only Look Once) framework.

Methods

Firstly, the lightweight LCNet is utilized to reconstruct the backbone network, with the purpose of reducing the number of parameters and computations of the model. Secondly, the GSConv module and the VOVGSCSP (Slim-neck by GSConv) module are introduced in the neck network, which makes it possible to minimize the number of model parameters and computations while guaranteeing the fusion capability among the different feature layers. Finally, coordinate attention is embedded in the tail of the backbone and after each VOVGSCSP module to improve the problem of detection accuracy degradation issue caused by model lightweighting.

Results

The experimental results show the LCGSC-YOLO can achieve an excellent detection performance with mean average precision of 95.5% and detection speed of 53 frames per second (FPS) on the mixed datasets of Plant Pathology 2021 (FGVC8) and AppleLeaf9.

Discussion

The number of parameters and Floating Point Operations (FLOPs) of the LCGSC-YOLO are much less thanother related comparative experimental algorithms.
Discrete element modelling and mechanical properties and cutting experiments of Caragana korshinskii Kom. stems
Authors: Qingqiu Cao , Shengwei Zhang , Tao Li , Gaixia Zhai , Hongfang Yuan
Published: October 2024

The forage crop Caragana korshinskii Kom. is of high quality, and the biomechanical properties of its plant system are of great significance for the development of harvesting equipment and the comprehensive utilisation of crop resources. However, the extant research on the biomechanical properties of Caragana korshinskii Kom. is inadequate to enhance and refine the theoretical techniques for mechanised harvesting. In this study, we established a discrete element model of CKS based on the Hertz-Mindlin bonding contact model. By combining physical experiments and numerical simulations, we calibrated and validated the intrinsic and contact parameters. The Plackett-Burman design test was employed to identify the significant factors influencing bending force, and the optimal parameter combination for these factors was determined through response surface analysis. When the shear stiffness per unit area was 3.56×109 Pa, the bonded disk scale was 0.93 mm, the normal stiffness per unit area was 9.68×109 Pa, the normal strength was 5.62×107 Pa, the shear strength was 4.27×107 Pa, the discrete element numerical simulation results for three-point bending, radial compression, axial tension, and shear fracture exhibited a maximum failure force error of 3.32%, 4.37%, 4.87% and 3.74% in comparison to the physical experiments. In the cutting experiments, a smaller radial angle between the tool edge and the stem resulted in less damage to the cutting section, which was beneficial for the smoothness of the stubble after harvesting and the subsequent growth of the stem. The discrepancy in cutting force between the physical and numerical simulations was 3.89%, and the F-x (force versus displacement) trend was consistent. The multi-angle experimental validation demonstrated that the discrete element model of CKS is an accurate representation of the real biomechanical properties of CKS. The findings offer valuable insights into the mechanisms underlying crop-machine interactions.