bluuebunny/crossref_metadata_2025 huggingface dataset:
Chuva de sementes em dois fragmentos de mata atlântica com diferentes níveis de degradação na Região Nordeste do Brasil
Authors: Milton Marques Fernandes  , Janaína Costa Chaves Silva  , Cassandra Mendonça Oliveira  , Deniver Dehuel Souza Oliveira  , Cilene Santos  , Alexandre de Siqueira Pinto  , Maiara Pedral Santos  , Renisson Neponuceno Araújo Filho
Published: June 2022

Este trabalho objetivou avaliar a chuva de sementes de espécies florestais em dois fragmentos com diferentes níveis de degradação na mata atlântica de Sergipe. O estudo foi desenvolvido em floresta estacional semidecidual no munícipio de São Cristóvão, SE. Foram delimitados um polígono na floresta aberta (de maior degradação) e um na floresta fechada (de menor degradação). Em cada polígono, alocaram-se dez coletores, e foram coletadas as sementes por 12 meses. Depois, os propágulos foram identificados em relação à espécie e classificados quanto a síndrome de dispersão, formas de vida e grupos ecológicos. Calcularam-se a densidade absoluta de sementes, a diversidade de Shannon e a equabilidade de Pielou. A floresta fechada apresentou dominância de propágulos das espécies Ficus clusiifolia, Cupania oblongifolia, Allophylus edulis e Myrcia tomentosa, que são zoocóricas, sendo fundamentais para a formação do banco de sementes e a regeneração natural. A retirada de madeira na floresta aberta reduz a quantidade de propágulos e aumenta o número de espécies não arbóreas na chuva de sementes. Portanto, o enriquecimento ou isolamento do fragmento são necessários. Duas espécies secundárias tardias apresentaram alta densidade de propágulos na floresta aberta, provavelmente originários de fragmentos mais preservados no entorno ou por dispersores específicos dessas espécies.
As aves dos campi universitários do Paraná: influência da área na riqueza de espécies
Authors: Ana Paula Zingler  , Vagner Cavarzere
Published: June 2022

Foi realizado inventário das aves no campus Santa Helena da Universidade Tecnológica Federal do Paraná (UTFPR-SH) por meio da metodologia de listas de 10 espécies para verificar, juntamente com os demais inventários de aves em campi universitários do Paraná, se a área de cada campus influenciaria na riqueza total de espécies registradas. Os ambientes da UTFPR, que possui 11 ha, abarcam áreas antropizadas, capinzais, fragmento florestal em estádio intermediário de sucessão (2,4 ha) e trecho de vegetação reflorestada que corresponde à faixa de proteção do Lago de Itaipu. Após 12 campanhas, foram acumuladas 48 listas, sendo registradas 84 e estimadas 95 espécies. Ao verificar a riqueza de espécies de mais cinco campi universitários paranaenses, verificou-se que a área do campus influenciou positiva porém não significativamente o número de espécies registradas em cada localidade. Desse modo, sugere-se que, no contexto de inventários, a diversidade-alfa será maior em localidades maiores, onde tenham sido amostrados mais ambientes.
Regeneração natural em fragmentos de floresta ombrófila mista de pequenas propriedades rurais no Paraná
Authors: Carla Fernanda Mussio  , Andrea Nogueira Dias  , Afonso Figueiredo Filho  , Pedro Higuchi  , Tiago Grespan  , Emilio Carlos Zilli Ruiz
Published: June 2022

O objetivo deste estudo foi avaliar a estrutura da regeneração natural de espécies arbóreas em fragmentos florestais de nove pequenas propriedades rurais na floresta ombrófila mista, no município de Fernandes Pinheiro, Paraná. A regeneração natural foi avaliada considerando três classes de tamanho: classe I, de 0,3 m a 1,0 m de altura; classe II, altura de 1,01 m a 3,0 m; e classe III, indivíduos com altura a partir de 3,01 m < 10 cm (DAP). A amostragem da regeneração natural foi realizada por meio de transecções permanentes de 10 m de comprimento, com largura de 2 metros, 6 metros e 14 metros, para as classes I, II e III, respectivamente. Foram instaladas 23 unidades amostrais, distribuídas entre nove propriedades rurais, incluindo locais com presença de animais domésticos de grande porte, ausência deles e locais com restrição recente da circulação. Escalonamento multidimensional não métrico foi empregado para detectar diferenças nas estruturas entre os ambientes. Nectandra grandiflora e Allophylus edulis foram as espécies mais expressivas nas áreas sem a ocorrência de animais. Em áreas com restrição de acesso de animais ou em locais com presença destes, Curitiba prismatica destacou-se como a espécie mais importante da regeneração natural.
Caracterização dendrológica das famílias Aquifoliaceae e Cardiopteridaceae em um remanescente de floresta ombrófila mista em Curitiba (PR)
Authors: Inti de Souza  , Christopher Thomas Blum
Published: June 2022

O uso de caracteres vegetativos é uma ferramenta importante para identificar as espécies arbóreas em levantamentos florestais. Assim, objetivou-se quantificar a riqueza das famílias Aquifoliaceae e Cardiopteridaceae (ordem Aquifoliales) em um remanescente florestal de Curitiba e elaborar uma chave dicotômica baseada em caracteres vegetativos para sua diferenciação. Após levantamento florístico efetuado por meio de expedições periódicas, foram selecionados preferencialmente 10 indivíduos de cada espécie, para análise de tronco, ritidoma (RI) e casca interna (CI). A caracterização de ramos e folhas foi realizada com a coleta de quatro ramos e mensuração de 10 folhas por ramo, preferencialmente de três indivíduos de cada espécie. Foram encontradas quatro espécies de Aquifoliaceae e duas de Cardiopteridaceae. As famílias distinguem-se pela presença de domácias foliares em Cardiopteridaceae (Citronella) e ausência destas em Aquifoliaceae (Ilex). C. gongonha diferencia-se de C. paniculata pela presença de ápice foliar mucronado. I. theezans apresenta folhas com margem predominantemente inteira, com 1-3 dentes próximos ao ápice, e I. paraguariensis possui folhas oblanceoladas. Por fim, I. brevicuspis tem folhas com base revoluta e razão comprimento/largura 2:1, enquanto I. dumosa apresenta folhas com razão comprimento/largura 3:1 e base não revoluta. Confirma-se, portanto, a possibilidade de diferenciação com base em caracteres vegetativos, sobretudo foliares.
Controle de fitopatógenos e qualidade de sementes de Oryza sativa L. tratadas com argila silicatada
Authors: Rommel dos Santos Siqueira Gomes  , Renato Francisco da Silva Souza  , José Luiz do Nascimento Junior  , Walter Esfrain Pereira  , Luciana Cordeiro do Nascimento
Published: June 2022

O arroz vermelho (Oryza sativa L.) é cultivado normalmente por pequenos agricultores, com sementes nativas ou de variedades tradicionais, com ampla base genética e adaptabilidade. Desse modo, faz-se necessário realizar estudos referentes à qualidade sanitária e fisiológica das sementes utilizadas para o cultivo, a fim de permitir resultados satisfatórios de produção e qualidade da semente. O objetivo da presente pesquisa foi determinar a eficiência de diferentes argilas silicatadas sobre patógenos e na qualidade fisiológica de sementes de O. sativa. As sementes foram imersas por dois minutos nas suspensões com Proagrim®, caulim, Rocksil®, Proagrim®+caulim, Proagrim®+Rocksil® e caulim+Rocksil® nas concentrações de 0, 10, 15 e 20 gL-1 de água destilada esterilizada e ao fungicida dicarboximida (24 g i.a.kg-1 de sementes). Avaliaram-se a sanidade das sementes, a primeira contagem, a germinação, o comprimento e a massa seca da parte aérea e da raiz. O Proagrim® e o caulim, independentemente de suas combinações, mostraram-se eficientes no controle de Fusarium oxysporum presente nas sementes. Verificou-se o maior teor de massa seca da raiz de plântulas quando se empregou caulim+Rocksil® a 10 gL-1. A redução na ocorrência de F. oxysporum e Curvularia lunata deu-se quando utilizados os tratamentos em comparação com a testemunha, evidenciando o potencial fungistático dos tratamentos.
MIR4435-2HG: A Tumor-associated Long Non-coding RNA
Authors: Zhao Fangnan , Liu Yuling , Tan Fangshun , Tang Lu , Du Zhuoying , Mou Jie , Zhou Gang , Yuan Chengfu
Published: June 2022

Background:

It is well known that the changes in the expression level of LncRNA can affect the
progression of tumors, which has caused a great upsurge of research in recent years. Several LncRNAs have
been identified to affect a series of cancers and can promote tumor growth, migration, and invasion. In this
review, we aim to clarify the pathophysiological functions of LncRNA MIR4435-2 HG in multiple tumors.

Methods:

By searching the literature through PubMed, this paper summarizes the relationship between
MIR4435-2HG and tumor and its role in the occurrence and development of cancer and also explains the specific
molecular mechanism of the effect of MIR4435-2HG on cancer.

Results:

MIR4435-2HG can function as an oncogene in a variety of cancers. The expression level was reported
to be abnormally elevated in a series of cancers, consisting of melanoma, gastric cancer, head and neck squamous
cell carcinoma, oral squamous cell carcinoma, lung cancer, cervical cancer, prostate carcinoma, ovarian
cancer, breast cancer, hepatocellular carcinoma, clear cell renal cell carcinoma malignant, glioma, and colorectal
cancer. Moreover, MIR4435-2HG is related to the poor prognosis of a variety of cancers. MIR4435-2HG
can also affect tumor proliferation, invasion, and apoptosis. In addition, MIR4435-2HG can also enhance the
metabolic function of myeloid dendritic cells of elite HIV-1 controllers.

Conclusion:

MIR4435-2HG affects the development of a variety of cancers. It can act as a clinical marker for
early tumor diagnosis and affects tumor-targeted therapy.
Phyllanthus emblica L. Regulates BDNF/PI3K Pathway to Modulate Glutathione
for Mitoprotection and Neuroprotection in a Rodent Model of Ischemic
Stroke
Authors: Bhattacharya Pallab , Sarmah Deepaneeta , Verma Geetesh , Datta Aishika , Vadak Namrata , Chaudhary Antra , Kalia Kiran
Published: June 2022

Introduction:

Ischemic stroke remains the leading cause of death worldwide and is the
primary cause of disability globally. Numerous studies have shown that plant-origin medicines are
promising and can influence the treatment of neurological disorders. Phyllanthus embilica L. (P.
emblica or Amla) is one of the herbal plants whose medicinal properties are widely studied. The
objective of the present study is to determine the neuroprotective effects of an aqueous extract of
the fruit of P. emblica (hereinafter referred to as just P. emblica) on cerebral ischemia-reperfusion
injury and explore if it can regulate BDNF/PI3K pathway to modulate glutathione for mitoprotection
and neuroprotection.

Methods:

In vivo studies were conducted on male Sprague Dawley rats, where rats were prophylactically
administered 100 mg/kg P. emblica for 30 days. In the treatment group, rats were given
100 mg/kg P. emblica, 1 h post middle cerebral artery occlusion (MCAo). Rats were evaluated for
neuro deficit and motor function tests. Brains were further harvested for infarct size evaluation,
biochemical analysis, protein expression studies, and mitochondrial studies.

Results:

Prophylaxis and treatment with P. emblica demonstrated significant improvement in
functional outcome with a reduction in infarct size. Normalization of glutathione, nitrite, and
malondialdehyde levels was also observed. Improvement in mitochondrial complex I and IV activities
was also reported. Expressions of BDNF, PI3K, SDF1 and VEGF increased while that of
ROCK2 decreased following P. emblica administration.

Conclusion:

P. emblica regulates BDNF/PI3K pathway to modulate glutathione in ischemic
stroke to confer mitoprotection and neuroprotection.
Hematotoxicity of Co-Administration of Bisphenol A and Acetaminophen in
Rats and its Amelioration by Melatonin
Authors: Akhter Mohammad S. , Rashid Hina , Hamali Hassan A. , Alshahrani Saeed , Dobie Gasim , Qadri Marwa , Madkhali Aymen M. , Mobarki Abdullah A.
Published: June 2022

Background:

Hematotoxicity is an underexplored end point of toxicity in most of the chemical exposures. An adverse effect on the hematological system arising out of xenobiotic exposure causes impaired hemostasis and coagulation leading to disease. BPA and acetaminophen are widely used synthetic chemicals the world over and both are known and have numerous toxic effects. Since both can be simultaneously exposed to humans over a period of time, we hypothesized that their exposure can cause hematotoxicity, which may be ameliorated by melatonin.

Objective:

In the current study, we aimed to find the effect of single and co-treatment of bisphenol A and acetaminophen on the RBC and coagulation factors in rats and amelioration of impairment by melatonin.

Methods:

Oxidative stress in red blood cells, bleeding time, blood clotting time, prothrombin time, and partial thromboplastin time, and fibrinogen levels were assessed as indicators of hematotoxicity. With treatment of bisphenol A and acetaminophen as single and co treatments and amelioration of the same by melatonin was evaluated.

Results:

An increase in RBC oxidative stress and decrease in bleeding time, blood clotting time, prothrombin time, and partial thromboplastin time along with an increase in fibrinogen levels was observed with bisphenol A and acetaminophen treatment, which was further aggravated with co-treatment of the two. Melatonin treatment, however, was seen to decrease the increase in oxidative stress and ameliorate the impairment in coagulation factors.

Conclusion:

Bisphenol A and acetaminophen cause an increase in oxidative stress in the red blood cells and cause a shift towards pro-coagulation, which is alleviated by treatment with melatonin.
O poema imortal de Christian Bök
Authors: Santos Andressa Nunes , Grando Diego
Published: June 2022

Christian Bök é um escritor e poeta conceitual canadense, professor de Escrita Criativa na Universidade de Melbourne, na Austrália. Na esteira de outros poetas conceituais que deram início ao campo de produção da arte transgênica, Bök engendrou um projeto híbrido entre as áreas da poesia e da biologia a fim de criar um poema vivo e imortal. Através de uma formação autodidata nas áreas de biologia molecular, biogenética e engenharia genética, o poeta desenvolveu, em teoria, uma forma de escrever um pequeno poema e introduzi-lo no DNA de uma bactéria resistente ao fogo, à água, à radiação e à própria explosão do Sol, capaz de sobreviver, inclusive, no espaço sideral. Além disso, parte do seu projeto era induzir a bactéria a ler o poema original e a produzir um verso poético em resposta. Este artigo descreve como Christian Bök comprovou em laboratório a viabilidade da sua teoria ao escrever um verso no DNA de uma bactéria modelo para estudos genéticos, a Escherichia coli, e obter dela, na sequência, um verso em resposta.
Representações de um passado deslembrado. A infância no exílio político nos filmes de Flávia Castro
Authors: Natalino Laís Gonçalves
Published: June 2022

Sabe-se que os exilados nutrem uma constante necessidade de reconstruir sua identidade (Said 2003) e, por vezes, têm a tarefa de desconstruir e reorganizar narrativas que cultivem a memória. A memória, por conseguinte, se configura como uma interpretação do passado e, portanto, como um processo de reconstrução deste passado a partir do presente e através da(s) linguagem(ens). Partindo do conceito de geração pós-memorial de Hirsch (2012), o presente artigo tem como objetivo analisar as narrativas fílmicas Diário de uma busca (2010) e Deslembro (2018), destacando a transmeabilidade entre a ficção e o real e aludindo ao binômio memória e história.  Para tanto, ancoro-me na concepção de tradução como recriação, representação e reprodução de memórias e fundamento minhas discussões em abordagens teóricas que se referem a processos de adaptação cultural e tradução intersemiótica. Em suma, a pesquisa observa as semelhanças e diferenças na construção das narrativas e no modo como a realizadora Flávia Castro traduz suas memórias da ditadura brasileira e do exílio político em diferentes formatos fílmicos, a saber, em um documentário e em uma ficção.
Os Autrans outros. Os muitos autores de um autor
Authors: Guimarães Jonatas
Published: June 2022

O século XX assistiu a um sistemático apagamento do sujeito no campo da teoria e da filosofia, que levaram a uma visão da literatura como linguagem dessubjetivada. Nesse contexto, nomes como Roland Barthes e Michel Foucault propuseram reflexões que viriam a abalar a noção de autor enquanto sujeito individual determinado social e historicamente e que seria dotado de capacidade criativa e de poder fundador. Contudo, observar os processos por meio dos quais os escritores automodelam sua própria imagem oferece a possibilidade de revisão desse desmanche do sujeito e do autor na literatura, permitindo visualizar a figura autoral como conjunto diverso de máscaras carregadas de significação social. É enquanto conjunto de máscaras em aliança e em tensão que Autran Dourado empreende a automodelagem de suas diversas personas. Dessa forma, analisarei a construção da figura autoral no livro O meu mestre imaginário, assinado por Erasmo Rangel, alter ego do autor, além de discutir as várias máscaras por que se apresenta em artigos publicados em jornais e revistas, bem como nos livros de ensaios teóricos do escritor.
Nova Roma e Nova Lusitânia: o Império Português nas obras de Camões e Gândavo
Authors: Batista Bianca Dorothéa
Published: June 2022

O objetivo deste artigo é analisar os conceitos de expansão marítima e império nas obras Os Lusíadas (1572), de Luís de Camões, e História da Província de Santa Cruz a que vulgarmente chamamos Brasil (1576), de Pero Magalhães de Gândavo. Camões defende que as viagens portuguesas às Índias projetaram Portugal como um novo império, uma Nova Roma, um império baseado no modelo romano, mas superior em conquistas e na língua. Gândavo, por sua vez, defende que a descoberta do Brasil projetou Portugal como um novo império na era moderna e, com isso, um novo modelo imperial a ser imitado e implementado, Nova Lusitânia.
Máxima visibilidade. O 'tradutor celebridade' no Brasil
Authors: Hanes Vanessa Lopes Lourenço
Published: June 2022

Apesar de o que Venuti (1995) chama de invisibilidade do tradutor revelar muito sobre o polissistema literário global, o oposto também acontece, mas esta perspectiva contrária é muito negligenciada. Este artigo apresenta três casos brasileiros que revelam diferentes facetas desta curiosa dinâmica mercadológica: (1) um romance de Agatha Christie no qual a tradutora, Clarice Lispector, tem tanta proeminência paratextual quanto a própria autora; (2) uma versão brasileira de muito destaque da tradução de Beowulf feita por Tolkien, ou seja, uma revivificação da tradução indireta motivada pelo mercado; e (3) Tradutores, uma série da editora Hedra que traz traduções feitas por renomados escritores lusófonos. Esta pesquisa demonstra a complexa rede de fatores envolvidos na visibilização de um tradutor no Brasil, fatores os quais podem também ocorrer em outros sistemas nacionais e internacionais.
{Serjoca}. O nome de um homossexual em ‘Ele me bebeu’, de Clarice Lispector
Authors: Linard Sérgio , Ferreira José Luiz
Published: June 2022

Discussão e análise do texto de Clarice Lispector, “Ele me bebeu”, com focalização no personagem “Serjoca”, considerando aspectos de sua performance de gênero e de sexualidade. Com base no método dialético de análise do texto literário, conforme Candido (2014), buscamos entender como a forma morfológica do substantivo “Serjoca” pode contribuir para a verticalização de interpretações do conto clariceano, a fim de identificar questões pertinentes ao debate dos estudos sobre a homossexualidade na literatura brasileira.
De Fradique a Fradique. A poética de Eça de Queirós
Authors: Harmuth Rosana Apolonia
Published: June 2022

A figuração da escrita e de escritores foi uma constante na obra de Eça. Tomando essa afirmação como mote, este texto objetiva refletir sobre essa insistência e sobre algumas das implicações desse procedimento. Para tanto, assume um caráter panorâmico em que vários romances ecianos são chamados para a discussão. Por um lado, essa visada nos permite refletir sobre o que os textos ficcionais têm a nos dizer, para além de seus enredos, a respeito da construção de uma poética eciana. Em outra frente, é possível perceber o que esses textos ficcionais nos dizem, de modo mais genérico, sobre a produção literária do período.
Hoe diep is het water van de doop?
Authors: Colijn J.J.A.
Published: June 2022

This article reflects on the Reformed theology and practice of infant baptism from an intercultural and ecumenical perspective. It looks at the socio-cultural and ecumenical context in which the Reformed theology and practice of infant baptism emerged, and the current Dutch context in which infant baptism is practiced and the appropriation of the Reformed theology and practice of infant baptism in the Reformed Churches in the Netherlands (lib.). It then examines the ecumenical questions around the practice of ‘re-baptism’, and makes a distinction between re-baptism as related to joining an Evangelical or Baptist church, and re-baptism of Reformed believers, who remain members of the Reformed Churches in the Netherlands (lib.). Finally, the article weighs the questions and topics on the future of the Reformed theology and practice of infant baptism in the Netherlands, especially against the background of the ecumenical conversation with Evangelical and Baptist Christians.
Caracterización morfológica y dasométrica de Mimosa trianae y Cassia moschata de la colección de AGROSAVIA
Authors: Castañeda Garzón Sandra L. , Moreno Barragán Jessica , Argüelles Cárdenas Jorge H. , Camargo Tamayo Hebert , Zuluaga Peláez Jhon J.
Published: June 2022

El cañafístulo (Cassia moschata Kunth) y el yopo (Mimosa trianae Benth.) son especies nativas de importancia económica en la Orinoquia Colombiana, sin embargo, se desconoce su variabilidad genética y su comportamiento en un sistema de monocultivo. En una plantación de siete años ubicada en el Centro de Investigación La Libertad (Villavicencio, Meta), se evaluó la variabilidad fenotípica de 108 árboles de M. trianae y 52 árboles de C. moschata empleando 37 descriptores cuantitativos y cualitativos de planta (copa, fuste, hoja). Se empleó un análisis de componentes principales y correspondencias múltiples, para las variables cuantitativas y cualitativas respectivamente, con el fin de reducir la dimensionalidad del conjunto de datos, complementados con un análisis de conglomerados, mediante el algoritmo de WARD. C. moschata presentó menor porte y una copa menos vigorosa, en comparación a M. trianae que se destacó por mayor número ramas, diámetro de copa, volumen de madera e incremento medio anual de la altura total y del diámetro del fuste. El análisis de conglomerados permitió clasificar los individuos de C. moschata y M. trianae en seis y cinco grupos respectivamente, reteniendo el 99.92% y el 99.58% de la variabilidad original. Para la selección de árboles maderables y su uso en sistemas agroforestales, las variables volumen de tronco, diámetro de copa, número de ramas y altura total, son las más importantes. En M. trianae el número de foliolos por hoja y el tamaño de las hojas son variables igualmente relevantes para selección de árboles de sombrío.
Sleep Patterns and Affect Dynamics Among College Students During the COVID-19 Pandemic: Intensive Longitudinal Study
Authors: Mousavi Zahra Avah , Lai Jocelyn , Simon Katharine , Rivera Alexander P , Yunusova Asal , Hu Sirui , Labbaf Sina , Jafarlou Salar , Dutt Nikil D , Jain Ramesh C , Rahmani Amir M , Borelli Jessica L
Published: June 2022

Background

Sleep disturbance is a transdiagnostic risk factor that is so prevalent among young adults that it is considered a public health epidemic, which has been exacerbated by the COVID-19 pandemic. Sleep may contribute to mental health via affect dynamics. Prior literature on the contribution of sleep to affect is largely based on correlational studies or experiments that do not generalize to the daily lives of young adults. Furthermore, the literature examining the associations between sleep variability and affect dynamics remains scant.

Objective

In an ecologically valid context, using an intensive longitudinal design, we aimed to assess the daily and long-term associations between sleep patterns and affect dynamics among young adults during the COVID-19 pandemic.

Methods

College student participants (N=20; female: 13/20, 65%) wore an Oura ring (Ōura Health Ltd) continuously for 3 months to measure sleep patterns, such as average and variability in total sleep time (TST), wake after sleep onset (WASO), sleep efficiency, and sleep onset latency (SOL), resulting in 1173 unique observations. We administered a daily ecological momentary assessment by using a mobile health app to evaluate positive affect (PA), negative affect (NA), and COVID-19 worry once per day.

Results

Participants with a higher sleep onset latency (b=−1.09, SE 0.36; P=.006) and TST (b=−0.15, SE 0.05; P=.008) on the prior day had lower PA on the next day. Further, higher average TST across the 3-month period predicted lower average PA (b=−0.36, SE 0.12; P=.009). TST variability predicted higher affect variability across all affect domains. Specifically, higher variability in TST was associated higher PA variability (b=0.09, SE 0.03; P=.007), higher negative affect variability (b=0.12, SE 0.05; P=.03), and higher COVID-19 worry variability (b=0.16, SE 0.07; P=.04).

Conclusions

Fluctuating sleep patterns are associated with affect dynamics at the daily and long-term scales. Low PA and affect variability may be potential pathways through which sleep has implications for mental health.
Efficacy of Personalized Diabetes Self-care Using an Electronic Medical Record–Integrated Mobile App in Patients With Type 2 Diabetes: 6-Month Randomized Controlled Trial
Authors: Lee Eun Young , Cha Seon-Ah , Yun Jae-Seung , Lim Sun-Young , Lee Jin-Hee , Ahn Yu-Bae , Yoon Kun-Ho , Hyun Min Kyung , Ko Seung-Hyun
Published: June 2022

Background

A system that combines technology and web-based coaching can help treat chronic conditions such as diabetes. However, the effectiveness of apps in mobile health (mHealth) interventions is inconclusive and unclear due to heterogeneous interventions and varying follow-up durations. In addition, randomized controlled trial data are limited, and long-term follow-up is lacking, especially for apps integrated into electronic medical records.

Objective

We aimed to assess the effect of an electronic medical record–integrated mobile app for personalized diabetes self-care, focusing on the self-monitoring of blood glucose and lifestyle modifications, on glycemic control in patients with type 2 diabetes mellitus.

Methods

In a 26-week, 3-arm, randomized, controlled, open-label, parallel group trial, patients with type 2 diabetes mellitus and a hemoglobin A1c (HbA1c) level of ≥7.5% were recruited. The mHealth intervention consisted of self-monitoring of blood glucose with the automatic transfer of glucose, diet, and physical activity counseling data (iCareD system). Participants were randomly assigned to the following three groups: usual care (UC), mobile diabetes self-care (MC), and MC with personalized, bidirectional feedback from physicians (MPC). The primary outcome was the change in HbA1c levels at 26 weeks. In addition, diabetes-related self-efficacy, self-care activities, and satisfaction with the iCareD system were assessed after the intervention.

Results

A total of 269 participants were enrolled, and 234 patients (86.9%) remained in the study at 26 weeks. At 12 weeks after the intervention, the mean decline in HbA1c levels was significantly different among the 3 groups (UC vs MC vs MPC: −0.49% vs −0.86% vs −1.04%; P=.02). The HbA1c level decreased in all groups; however, it did not differ among groups after 26 weeks. In a subgroup analysis, HbA1c levels showed a statistically significant decrease after the intervention in the MPC group compared with the change in the UC or MC group, especially in patients aged <65 years (P=.02), patients with a diabetes duration of ≥10 years (P=.02), patients with a BMI of ≥25.0 kg/m2 (P=.004), patients with a C-peptide level of ≥0.6 ng/mL (P=.008), and patients who did not undergo treatment with insulin (P=.004) at 12 weeks. A total of 87.2% (137/157) of the participants were satisfied with the iCareD system.

Conclusions

The mHealth intervention for diabetes self-care showed short-term efficacy in glycemic control, and the effect decreased over time. The participants were comfortable with using the iCareD system and exhibited high adherence.

Trial Registration

Clinical Research Information Service, Republic of Korea KCT0004128; https://tinyurl.com/bdd6pa9m
Error and Timeliness Analysis for Using Machine Learning to Predict Asthma Hospital Visits: Retrospective Cohort Study
Authors: Zhang Xiaoyi , Luo Gang
Published: June 2022

Background

Asthma hospital visits, including emergency department visits and inpatient stays, are a significant burden on health care. To leverage preventive care more effectively in managing asthma, we previously employed machine learning and data from the University of Washington Medicine (UWM) to build the world’s most accurate model to forecast which asthma patients will have asthma hospital visits during the following 12 months.

Objective

Currently, two questions remain regarding our model’s performance. First, for a patient who will have asthma hospital visits in the future, how far in advance can our model make an initial identification of risk? Second, if our model erroneously predicts a patient to have asthma hospital visits at the UWM during the following 12 months, how likely will the patient have ≥1 asthma hospital visit somewhere else or ≥1 surrogate indicator of a poor outcome? This work aims to answer these two questions.

Methods

Our patient cohort included every adult asthma patient who received care at the UWM between 2011 and 2018. Using the UWM data, our model made predictions on the asthma patients in 2018. For every such patient with ≥1 asthma hospital visit at the UWM in 2019, we computed the number of days in advance that our model gave an initial warning. For every such patient erroneously predicted to have ≥1 asthma hospital visit at the UWM in 2019, we used PreManage and the UWM data to check whether the patient had ≥1 asthma hospital visit outside of the UWM in 2019 or any surrogate indicators of poor outcomes. Such surrogate indicators included a prescription for systemic corticosteroids during the following 12 months, any type of visit for asthma exacerbation during the following 12 months, and asthma hospital visits between 13 and 24 months later.

Results

Among the 218 asthma patients in 2018 with asthma hospital visits at the UWM in 2019, 61.9% (135/218) were given initial warnings of such visits ≥3 months ahead by our model and 84.4% (184/218) were given initial warnings ≥1 day ahead. Among the 1310 asthma patients in 2018 who were erroneously predicted to have asthma hospital visits at the UWM in 2019, 29.01% (380/1310) had asthma hospital visits outside of the UWM in 2019 or surrogate indicators of poor outcomes.

Conclusions

Our model gave timely risk warnings for most asthma patients with poor outcomes. We found that 29.01% (380/1310) of asthma patients for whom our model gave false-positive predictions had asthma hospital visits somewhere else during the following 12 months or surrogate indicators of poor outcomes, and thus were reasonable candidates for preventive interventions. There is still significant room for improving our model to give more accurate and more timely risk warnings.

International Registered Report Identifier (IRRID)

RR2-10.2196/5039
Generación de una ecuación de predicción de espacio requerido a través del análisis de regresión lineal y su comparación con respecto a los métodos de Moyers y Tanaka-Johnston, en adolescentes de 12-14 años en la U. E. «Darío Guevara Mayorga», Quito-Ecuad
Authors: Pazmiño Ortiz Darío Wladimir , Proaño Rodríguez Ana Mishel
Published: June 2022

Desde la creación de las tablas de Moyers en 1958 y el método de Tanaka-Johnston en 1974, los cuales predicen el espacio requerido para que erupcionen los caninos y premolares, se ha venido cuestionando su efectividad al momento de aplicar en otras etnias diferentes en las que se realizaron dichos estudios; a nivel de Sudamérica, en donde encontramos etnia mestiza diferente a la etnia blanca, muestra realizada para la creación de las tablas de Moyers y el método de Tanaka-Johnston, al aplicar dichos métodos la mayoría de los estudios concluyeron que sus valores predictivos no son acordes a los valores reales. El presente trabajo generó una ecuación de predicción de espacio requerido por medio de coefi - cientes de correlación de Pearson y su posterior creación mediante la regresión lineal con valores de nuestra población, tanto para mujeres como para hombres, luego se procedió a comparar su efi cacia con respecto a los dos métodos antes mencionados, obteniendo y concluyendo que en mujeres y hombres la ecuación generada fue más efi caz que dichos métodos.
Instrumentos musicales como factor etiológico de maloclusiones
Authors: Guzmán Valderrábano Claudia Patricia , Durán Gutiérrez Américo , Hernández Carvallo José Ramón , Valdivia Gómez Isaac Guzmán
Published: June 2022

El uso constante de la ejecución de los instrumentos musicales puede afectar gravemente a la oclusión dentaria, ya que, sólo se requieren menos de 100 g de presión para mover ortodóncicamente una pieza dentaria, y se ha logrado medir la fuerza con que se apoyan estos instrumentos sobre los tejidos orales, alcanzando algunos de ellos los 500 g de presión. Los instrumentos de aliento tales como fl auta transversa, trompeta, trombón y tuba están en contacto directo con los labios y para ejecutarlos es necesario ejercer una presión interna del aire hacia la boquilla del instrumento, lo que provoca lesiones en los músculos, pero también infl uye en la posición de los incisivos y la posición mandibular que lleva al ejecutar este tipo de instrumentos. También hay instrumentos de cuerda como el violín y la viola que, al estar en contacto directo con la mandíbula y al ejercer presión sobre ella para la colocación correcta del instrumento, pueden causar una desviación mandibular, problemas articulares y de oclusión al ejecutante. Debemos considerar la fuerza que ejerce el instrumento musical sobre el aparato masticatorio, la posición, el tiempo de ejecución y la edad en que se inicia el estudio de éste; ya que, al haber una fuerza directa externa y repetitiva causa diversas alteraciones en los músculos, huesos, dientes y articulaciones. Es importante que, desde el inicio y durante el uso del instrumento musical, el músico acuda periódicamente al ortodoncista para la prevención y control de las maloclusiones y así evitar el desarrollo de una disfunción que pueda causarle a largo plazo la imposibilidad de tocar su instrumento. Cuando el músico inicia la ejecución de su instrumento desde edades tempranas es importante que sea observado y si es necesario, tratado ortopédicamente, debido a que éste puede causarle maloclusiones esqueléticas y dentales por encontrarse en etapa de crecimiento y desarrollo.
Tratamiento ortodóntico-quirúrgico. Paciente clase III con asimetría por desviación mandibular. Reporte de un caso
Authors: Oviedo Mojica Norma , Guzmán Valdivia Gómez Isaac
Published: June 2022

Reporte de un caso: Las asimetrías craneofaciales se expresan como las diferencias en tamaño o relación entre dos partes de la cara. El tratamiento de las asimetrías dentarias es ortodóntico, ya sea por medio de ajustes oclusales, férulas o aparatología fi ja. En las asimetrías esqueletales suele ser necesario recurrir a la cirugía, especialmente en casos en donde no hay crecimiento. El objetivo del tratamiento ortodóntico-quirúrgico es conseguir una armonía craneofacial. Para poder planifi car un tratamiento se deben considerar: etiología, gravedad, localización de la alteración, edad y motivación del paciente. Se presenta en este artículo el diagnóstico y tratamiento de una paciente de 21 años 1 mes de edad con clase III esqueletal, clase III molar bilateral, clase III canina izquierda, clase canina no valorable derecha, mordida cruzada anterior, proinclinación dental inferior, retroinclinación dental superior, desviación mandibular hacia la izquierda y crecimiento vertical. Se decide por un tratamiento ortodóntico-quirúrgico. El plan de tratamiento se realiza ortodóntico-quirúrgico en tres fases: fase ortodóntica prequirúrgica con la colocación de sistema Roth 0.022, en la fase quirúrgica se realiza una retroposición mandibular con técnica de osteotomía sagital de rama ascendente y corrección de laterognasia, y en la fase ortodóntica postquirúrgica se consigue clase I dentoesqueletal con una buena armonía facial y perfi l recto. Conclusión: La comunicación entre el ortodoncista y el cirujano maxilofacial es indispensable para lograr los objetivos del tratamiento y éxito en el mismo, así como de los conocimientos y experiencia de los profesionales implicados en su tratamiento.
Primeras páginas 14(1)
Authors: Research Journal UNED
Published: June 2022

Primeras páginas 14(1) Junio 2022
Using the inner membrane of Escherichia coli as a scaffold to anchor enzymes for metabolic flux enhancement
Authors: Wang You , Wang Yushu , Wu Yuqi , Suo Yang , Guo Huaqing , Yu Yineng , Yin Ruonan , Xi Rui , Wu Jiajie , Hua Nan , Zhang Yuehan , Zhang Shaobo , Jin Zhenming , He Lin , Ma Gang
Published: June 2022

Clustering enzymes in the same metabolic pathway is a natural strategy
to enhance productivity. Synthetic protein, RNA and DNA scaffolds have
been designed to artificially cluster multiple enzymes in the cell,
which require complex construction processes and possess limited slots
for target enzymes. We utilized the Escherichia coli inner cell membrane
as a native scaffold to cluster four fatty acid synthases and achieved
to improve the efficiency of fatty acid synthesis in vivo. The
construction strategy is as simple as fusing target enzymes to the
N-terminus or C-terminus of the membrane anchor protein (Lgt), and the
number of anchored enzymes is not restricted. This novel device not only
presents a similar efficiency in clustering multiple enzymes to that of
other artificial scaffolds but also promotes the product secretion,
driving the entire metabolic flux forward and further increasing the
gross yield compared with that in a cytoplasmic scaffold system.
Organizational Characteristics of European Pediatric Onco-Critical Care: An International Cross-Sectional Survey.
Authors: Nielsen Jeppe S.A. , Agbeko Rachel , Bate Jessica , Jordan Iolanda , Dohna-Schwake Christian , Potratz Jenny , Moscatelli Andrea , Bottari Gabriella , Pappachan John , Witt Volker , Crazzolara Roman , Amigoni Angela , Mizia-Malarz Agnieszka , Martín Mariá Sánchez , Willems Jef , Heuvel-Eibrink Marry Van den , Schlapbach Luregn J. , Asperen Roelie Wösten-Van
Published: June 2022

Background: Intensified treatment protocols have improved
survival of pediatric oncology patients. However, these treatment
protocols are associated with increased treatment-related morbidity
requiring admission to pediatric intensive care unit (PICU). We aimed to
describe the organizational characteristics and processes of care for
this patient group across PICUs in Europe. Methods: A web-based
survey was sent to PICU directors or representative physicians between
February and June 2021. Results: Responses were obtained from
77 PICUs of 12 European countries. Organizational characteristics were
similar across the different countries of Europe. The median number of
PICU beds was 12 (IQR 8-16). The majority of the PICUs was staffed by
pediatric intensivists and had a 24/7 intensivist coverage. Most PICUs
had a nurse-to-patient ratio of 1:1 or 1:2. The median numbers of yearly
planned and unplanned PICU admissions of pediatric cancer patients were
20 (IQR 10-45) and 10 (IQR 10-30, respectively. Oncology specific
practices within PICU were less common in participating centres. This
included implementation of oncology protocols in PICU (30%), daily
rounds of PICU physicians on the wards (13%), joint mortality and
morbidity meetings or complex patients’ discussions (30% and 40%,
respectively) and participation of parents during clinical rounds
(40%). Conclusion: Our survey provides an overview on the
delivery of critical care for oncology patients in PICU across European
countries. Multidisciplinary care for these vulnerable and challenging
patients remains complex and challenging. Future studies need to
determine the effects of differences in PICU organization and processes
of care on patients’ outcome.
Seminal plasma selenium concentrations, sperm mtDNAcn, and semen quality: association and mediation analyses among healthy Chinese men
Authors: Chen Heng-Gui , Sun Bin , Lin Fuxin , Chen Ying-Jun , Xiong Chengliang , Meng Tian-Qing , Duan Peng , Messerlian Carmen , Hu Zhijian , Pan An , Ye Weimin , Wang Yixin
Published: June 2022

Objective: To investigate the associations of seminal plasma selenium
(Se) concentrations with semen quality and to explore the mediating role
of sperm mitochondrial DNA copy number (mtDNAcn). Design:
Cross-sectional study with repeated measurements. Setting: Hubei
Province Human Sperm Bank of China. Population: A total of 1159 healthy
men who repeatedly provided 5617 semen samples were included. Main
Outcome Measures: Seminal plasma Se concentration and sperm mtDNAcn of
healthy men screened as potential sperm donors were determined using
inductively coupled plasma mass spectrometry (ICP-MS) and real-time
fluorescent quantitative PCR (RT-qPCR), respectively. Methods: Linear
mixed-effects models and mediation analyses were performed. Result(s):
After adjusting for potential confounders, we observed positive
associations of seminal plasma Se concentrations with sperm
concentration and total count (both p-Values for trend <
0.001). Volunteers in the highest vs. lowest quartiles of seminal plasma
Se concentrations had 70.1% (95% CI: 53.3%, 88.9%) and 59.1% (95%
CI: 40.5%, 80.2%) higher sperm concentration and total count,
respectively. We also found inverse associations between within-subject
pooled seminal plasma Se concentrations and sperm mtDNAcn, and between
sperm mtDNAcn and sperm concentration, total count, total motility, and
progressive motility (all p-Values for trend < 0.05).
Mediation analyses showed that sperm mtDNAcn mediated 19.7% (95% CI:
15.9%, 25.3%) and 23.1% (95% CI: 17.4%, 33.4%) of the associations
between within-subject average seminal plasma Se concentrations and
sperm concentration and total count, respectively. Conclusions: Seminal
plasma Se concentrations were positively associated with sperm
concentration and total count, which was partly mediated by sperm
mtDNAcn.
A rare bioprosthetic valve complication: Flail leaflet related to late cusp tear
Authors: Turkmen Irem , Sancar Kadriye Memic , Güler Arda , GODE SAFA , Guler Gamze Babur
Published: June 2022

Bioprosthetic valves have risk of gradual valve degeneration and
dysfunction in follow-up period. In this case report, we describe a
72-year-old man who suffered from severe transvalvular mitral valve
regurgitation due to isolated rupture of the bioprosthetic mitral valve
without significant degeneration, calcification and thickness. We would
like to emphasize this rare prosthetic valve-related complication in a
10-year-old bioprosthetic valve.
Explosive behavior and rational bubbles: Evidence from the Serbian hyperinflation at daily frequency
Authors: Petrovic Pavle , Mladenovic Zorica
Published: June 2022

Using recently developed right-tailed sequential unit root tests at daily
frequency in the extreme portion of the Serbian hyperinflation, we found
that the money supply and the exchange rate exploded while the economy was
approaching the maximum of the inflation tax Laffer curve, and remained
explosive while on the wrong, decreasing side of that curve throughout the
end of the hyperinflation. Money supply exploded as government tried first
to raise seigniorage to a new higher plateau, and subsequently to prevent,
albeit unsuccessfully, a decline in seigniorage while the economy was
sliding down the decreasing side of the Laffer curve. The rational bubble
was not found as the exchange rate explosiveness was driven by the
explosiveness of its fundamental value: current and expected future money
supply. Thus, even the extreme portion of the Serbian hyperinflation was
driven by ever expanding money supply in the government quest for additional
seigniorage and not by the rational bubbles.
Clinica com infans
Authors: Melo Adriana Fontes
Published: June 2022

Este artigo problematiza a expressões de linguagem nos primeiros meses de vida, a partir do discernimento, no corpo do infans, de sinais que insistem em contraposição à esperada harmonia no laço que o outro propõe para atar-se ao bebê. Pais e bebê chegam à clínica psicanalítica quando o médico não reconhece nesses sinais indícios de sintomatologia orgânica. Admitindo o corpo como lugar de registro singular desse efeito perturbador, recorro a um evento clínico para diferenciar uma ação ocasional de uma marca psíquica distintiva. Afinal, certas incidências referem-se a uma separação em curso, precipitada como configuração sintomática de um funcionamento psíquico.
Analisis Berpikir Kreatif Siswa dalam Pemecahan Soal Cerita pada Materi Pecahan Berdasarkan Jenis Kelamin
Authors: Firdaus Anisa , Shodikin Ali
Published: June 2022

This research aims to explain and identify students' creative thinking skills in solving story problems on fractional material based on gender. This research method is a descriptive qualitative research. The subjects of this research were grade VII students of MTs Ma'arif Sungegeneng which included male students with high thinking ability (SPT), female students with high thinking ability (SWT), male students with moderate thinking ability (SPS), female students with moderate thinking ability. (SWS), male students with low thinking ability (SPR), female students with low thinking ability (SWR). High, medium, low skills were determined based on the results of written tests and interviews. The method of collecting information is by giving questions consisting of 3 story questions about fractions and interviews. The results of the analysis show that the creative thinking skills of male and female students are different, where female students have superior creative thinking skills than male students.
Validitas Modul Elektronik “Pembelahan Sel” Berbasis Keterampilan Berpikir Kritis
Authors: Astuti Nadia , Kaspul Kaspul , Riefani Maulana Khalid
Published: June 2022

Along with the rapid development of the times, the use of technology is widely used by students in schools. The use of technology-based teaching aids will make teaching and learning activities more fun, easy, and efficient. One of the teaching aids is teaching materials. Teaching materials that are easy, practical, and close to life will make it easier for students to understand the lesson. Cell division material is still considered a difficult learning material. This is because the characteristics of the object are indeed difficult to be presented in real to students. Therefore, research and development on teaching materials are carried out in the form of cell division material modules for class XII SMA based on critical thinking skills. This research and development aim to describe the validity of the e-module material for class XII high school cells based on critical thinking skills. This type of research is research and development with a 4D model. Aspects of validity include aspects of compatibility and participation. The research data were analyzed descriptively in categories. The results showed that the e-module developed was in the very appropriate category with a value of 3.83, which means that this e-module was in accordance with the objectives of learning Biology at SMA 4 Banjarmasin and received a feasibility score of 3.93 in the very feasible category, which means that the module is technically very feasible to be used as a source of learning Biology.