bluuebunny/crossref_metadata_2025 huggingface dataset:
A COVID-19 Case: Isolated and Persistent Headache
Authors: Yalçın Çiğdem , Çelik Ali Kutta
Published: September 2024

COVID-19 effects many systems such as respiratory, nervous, renal and hematologic system. Third of patients have experienced neurological symptoms such as headache, anosmia, ageusia, and dizziness. Headache has been reported as the most common neurological manifestation but cases just headache are extremely rare. This case is a Covid-19 case with no symptoms other than sudden onset headache. The result of the nasal swab PCR sampling was negative however local infiltration areas with ground glass density in the periphery of the middle lobe, lateral segment of the both lungs were detected in the thorax CT.
Measurement of Serum Ceruloplasmin, Lipid Hydroperoxide Level and Prolidase Activity in Children with Primary Headache
Authors: Karakas Serdar , Calik Mustafa , Koyuncu Ismail , Shermatov Kabil
Published: September 2024

Introduction
Primary headache is a significant health problem in children as it remarkably negatively affects the child and his/her family. Migraine and tension-type headaches constitute the majority of primary headaches in childhood. Studies regarding adult migraine patients suggest that oxidative stress has a significant role in the pathogenesis. This study aimed to investigate the relationship between primary headache in chidhood and the levels of oxidative stress markers.
Materials and methods
Pediatric patients diagnosed with primary headache and healthy controls in the pediatric age range were recruited. Data regarding age, gender, height, weight, and body mass index (BMI) were recorded. The levels of ceruloplasmin, lipid hydroperoxide, and prolidase activity were measured in plasma using the ELISA method. Statistical analyses were conducted using the SPSS 11.5 statistical program. A p-value of less than 0.05 was considered significant.
Results
The study included 76 patients with primary headache and 61 healthy controls. The mean ages of the patients and healthy controls were 14.4±3.2 and 13.6±2.9 years. The patient and control groups were similar in terms of gender distribution (p=0.948), age (p=0.079), and BMI (p=0.196). Migraine accounted for 35.5% (n=27), while tension-type headache accounted for 64.5% (n=49) of the patients. Serum ceruloplasmin (p=0.033), lipid hydroperoxide (p<0.001), and prolidase (p=0.010) levels were higher in patients compared to the control group. Lipid hydroperoxide (p=0.021) and prolidase (p=0.013) levels were higher in migraine patients than in tension-type headache patients, while ceruloplasmin levels were similar between patients with different headache types (p=0.581).
Conclusion
In this study, oxidative stress markers were shown to be increased in pediatric patients with primary headache. These findings support the hypothesis that patients with primary headaches are exposed to oxidative stress. Future studies may elucidate the role of oxidative stress in the etiopathogenesis of childhood migraine and other headache types.
Nutrient Intake and Nutritional Status of Blood Cancer Patients at a Tertiary Hospital in India: A Cross-Sectional Descriptive Analysis of Leukemia, Lymphoma and Multiple Myeloma
Authors: Topisia Enock , Wang’ondu Loise Wamahiga
Published: September 2024

In 2018, there were an estimated 18 million cancer cases worldwide, with lymphoma, multiple myeloma, and leukemia contributing to a significant portion of these cases. Lymphoma accounted for 79,990 cases, multiple myeloma for 159,985 cases, and leukemia for 437,033 cases globally (AICR, 2018). In the United States alone, approximately 30,770 people are diagnosed with multiple myeloma each year. Multiple myeloma comprises about 1.8% of all cancers and around 10% of all “blood cancers,” which includes leukemia (Penn Medicine, 2020). India ranks third in the highest reported cases of blood cancer, following the United States and China, affecting more than 70,000 men and women in the country. This study aimed to determine patients’ nutritional status and nutrient intake, following and before a diagnosis of leukemia, lymphoma, and/ or multiple myeloma, using a cross-sectional survey, as the aspect of health care at Apollo Hospitals, India. Findings showed that nutrient intake following diagnosis with leukemia, lymphoma and/ or multiple myeloma will reduce and as a result patient will trend in weight loss. This study suggests that after diagnosis with leukemia, lymphoma, and/ or multiple myeloma patients will experience difficulty in meeting nutrient requirements. The intake will be deficit compared to the Recommended Dietary Allowance (RDA) for Indians and the general guidelines for patients with cancer and/ or on chemotherapy. Hence, the hospital ought to carry out continuous quality improvement in nutrition care with surveys and interventions repeated indefinitely.
New taxa and new records of Winnertziinae and Porricondylinae (Diptera: Cecidomyiidae) from Germany
Authors: Jaschhof Mathias
Published: September 2024

Winnertziinae and Porricondylinae are two subfamilies of mycophagous Cecidomyiidae (gall midges). An earlier census in 2021 found the German fauna of both groups to comprise 53 species and 28 genera – only a small proportion of the nearly 400 species and 75 genera known from all of Europe. A 24-month inventory in 2021‒2023, whose most significant taxonomic and faunistic outcomes are presented here, yielded evidence of an additional 142 species and 24 genera present in Germany, more precisely 41 species and three genera of Winnertziinae, and 101 species and 21 genera of Porricondylinae. Included in these numbers are 30 new species (six Winnertziinae, 24 Porricondylinae) and one new genus (of Porricondylinae) described and named here. The number of potentially new species discovered during the project is considerably larger (85+), but the too poor condition of the specimens and various other circumstances do not permit their taxonomic description at this stage. New taxa named in the present paper are Johnsonomyia szadziewskii sp. nov., Rhipidoxylomyia bilobata sp. nov., Winnertzia haushoferorum sp. nov., Winnertzia incrassata sp. nov., Winnertzia macrodens sp. nov., Winnertzia subdentata sp. nov., all Winnertziinae, Asynapta doczkali sp. nov., Asynapta falcata sp. nov., Bryocrypta longissima sp. nov., Camptomyia serrata sp. nov., Cassidoides rainensis sp. nov., Cassidoides riparius sp. nov., Claspettomyia gracilostylus sp. nov., Claspettomyia parvidentata sp. nov., Divellepidosis bavarica sp. nov., Lamellepidosis luderbuschensis sp. nov., Neurepidosis hartschimmelhofensis sp. nov., Neurepidosis simplex sp. nov., Parepidosis lobata sp. nov., Porricondyla acutistylata sp. nov., Porricondyla insolita sp. nov., Porricondyla oblonga sp. nov., Porricondyla ornata sp. nov., Porricondyla pilosoides sp. nov., Porricondyla plana sp. nov., Porricondyla pumila sp. nov., Schistoneurus paraimpressus sp. nov., Schistoneurus subimpressus sp. nov., Spungisomyia germanica sp. nov., Wohllebenia gen. nov., and Wohllebenia hybrida gen. et sp. nov., all Porricondylinae. Taxonomic descriptions are based on both the morphology of males and, if available, CO1 (DNA barcode) sequences, using specimens collected by Malaise traps in Bavaria and Baden-Württemberg, the two southernmost federal states of Germany. Released here are 150 BINs new to BOLD as well as 145 species names for previously unidentified BINs in BOLD. Redescriptions of male morphology are provided for Camptomyia heterobia Mamaev, 1961, Claspettomyia carpatica Mamaev, 1998, Dicerura scirpicola Kieffer, 1898, and Winnertzia betulicola Mamaev, 1963. The state of knowledge of Germany’s fauna of mycophagous gall midges is discussed.
Turkey's wave energy potential: A PESTLE Analysis
Authors: Çeçen Mehmet
Published: September 2024

Turkey's energy landscape is characterised by a dynamic fusion of nonrenewable and renewable sources, which are crucial for meeting the nation's electricity demands. Sources, such as natural gas and coal derivatives, ensure grid stability, while renewables, such as hydroelectric, solar, and wind power, underscore Turkey's commitment to sustainability. Although there are currently no grid-connected wave energy plants, initiatives such as the OREN Ordu Energy project demonstrate the country's growing interest in wave energy. Turkey aims to integrate wave energy into its renewable energy mix, with the help of supportive regulations and incentives. This will bolster resilience and reduce environmental impact. However, successful integration requires overcoming regulatory hurdles, technological advancements, and environmental concerns. This study discusses the potential of wave energy and the importance of increasing the rate of renewable energy, with a PESTLE analysis.
CYBER SECURITY GOVERNANCE; IMPLICATIONS FOR PAKISTAN’S NATIONAL SECURITY
Authors: Muhammad Umar Farooq Baloch
Published: September 2024

Networks for information and communication technologies form the backbone of the global cyberspace. These networks operate across physical borders and hold vital data and information that is essential to the national security of any nation. In the modern digital sphere, these networks are frequently vulnerable to cyber threats and attacks. One of the most important security concerns in the modern world is cyber warfare, which is a term coined to describe this conundrum. In response, the nations are making significant investments to fortify the security of their cyber frontiers and to assemble a formidable cyber force to defend their cyberspace. Similarly, Pakistan's national security is under grave threat from the ongoingcyber frontiersThis article seeks to elucidate Pakistan's current cyber challenges as well as the steps that country should take to counteract sophisticated cyber security threats. In order to protect Pakistan's national security, this article will also highlight the creation of a framework and governance mechanism for cyber security along with suggested courses of action that are in line with the country's cyber policy.
Kompetensi dan Motivasi Sumber Daya Manusia dalam Pembelajaran
Authors: Juhra Al
Published: September 2024

The human resources issue remains the focus and focus of an organization's ability to survive in the age of globalization. Human resources will determine the success of the organization's activities. This research aims to find out how the competence and motivation of human resources in learning. This analysis uses qualitative methods with descriptive approaches, data collection obtained through observations, interviews, and documentation. Determination of informants using purposive sampling techniques, then once research data is collected then analyzed using data analysis techniques. The results of the research show that the improvement in the quality of individual and organizational performance will occur in a learning organization that is able to combine leadership functions, managers' competencies and cultures that enable the competence to develop and be used optimally in the form of a continuous innovation contribution in the organization.
Metodología para la aplicación de la NIC 41 a la producción del sector porcino del cantón La Mana
Authors: Llanqui Toaquiza Jessica , Sacón Alcívar Nallely , Hurtado García Ketty del Rocío , Ulloa Méndez Carmen Isabel
Published: September 2024

La producción porcina en el cantón La Maná es vital tanto económica como socialmente, ofreciendo alimentos esenciales y beneficiándose de ventajas competitivas como su ubicación, suelo favorable y bajos costos productivos. La industria busca producir carne de calidad para satisfacer la demanda nacional a precios accesibles, mejorando técnicas y aspectos económicos para competir eficazmente. Este estudio aplica la Norma Internacional de Contabilidad 41 (NIC 41) al costeo del proceso de producción porcina en La Maná, mediante un estudio descriptivo y analítico realizado en 2023. Utilizando datos reales y encuestas validadas, se evaluaron los costos de producción en pequeños productores de Pucayacu, Guasaganda y Esperanza, enfocándose en razas como Landrace x Pietrain, Landrace x Duroc y Landrace x Criollo. Se identificaron costos clave de alimentación, cuidados veterinarios, mano de obra y otros gastos operativos. Los datos fueron analizados utilizando Excel, asegurando precisión y consistencia. La aplicación de la NIC 41 permite medir y reconocer los activos biológicos al valor razonable menos los costos de venta, asegurando transparencia y comparabilidad en los informes financieros. El análisis mostró que el resultado operativo en efectivo fue de $3,601.20, y el resultado neto contable, incluyendo el valor razonable, fue de $6,352.40, destacando la importancia de gestionar eficazmente los costos y reconocer los cambios en el valor razonable para maximizar el rendimiento financiero. La implementación de la NIC 41 en La Maná no solo mejora la precisión contable, sino que también proporciona una base sólida para la toma de decisiones estratégicas, recomendando una gestión rigurosa de costos y adopción de tecnologías avanzadas para el seguimiento de la producción porcina.
Cirugía en útero Frente al Diagnóstico de la Espina Bífida
Authors: Cuzco Cusco Dalila Teresa , Ramírez Portilla Cristian Carlos
Published: September 2024

Durante el desarrollo del sistema nervioso central normal pueden desarrollarse defectos congénitos, la espina bífida, a consecuencia del desarrollo incompleto del tubo neural entre la tercera y cuarta semana gestacional, como método correctivo se han desarrollado dos técnicas: la cirugía postnatal y la cirugía in útero o prenatal, está última expone el tubo neural fetal y corrige su cierre prematuro, se la realiza en las primeras semanas de gestación. Su diagnóstico es realizado principalmente a través del ultrasonido prenatal y pruebas de laboratorio, como la alfa-fetoproteína. El objetivo se centra en identificar los beneficios del tratamiento mediante la cirugía in útero frente al diagnóstico de espina bífida. Se realizó una revisión bibliográfica de tipo scoping review. Para la búsqueda de la bibliografía se establecieron criterios de inclusión y exclusión, y esta se la realizó en bases de datos científicas como: Scopus, PubMed, SienceDirect y Springer Lin. Cada uno de los artículos a utilizarse se les agrego al gesto bibliográfico Zotero. Con los resultados se dio a conocer los beneficios de la aplicación de la cirugía in útero en fetos con diagnóstico de espina bífida frente al desarrollo de complicaciones y limitaciones físicas y psicológicas que desencadena esta enfermedad. La aplicación de la cirugía in útero en los pacientes ha mejorado considerablemente su estilo de vida, disminuyendo la mortalidad y complicaciones neurológicas, motoras y de esfínteres, también intervenciones médicas adicionales como la derivación ventriculoperitoneal y cirugías invasivas para los niños.
El Rol de la IA en la Enseñanza de Matemáticas en Entornos Virtuales
Authors: Román Cañizares Gloria Narcisa
Published: September 2024

Esta investigación examina el impacto de la inteligencia artificial (IA) en la enseñanza de matemáticas en entornos virtuales, destacando su creciente importancia para la personalización del aprendizaje y la mejora de la experiencia educativa. El objetivo principal fue explorar cómo las herramientas basadas en IA pueden optimizar la enseñanza matemática en plataformas digitales, analizando su influencia en el rendimiento académico y la motivación de los estudiantes. Se empleó una metodología de revisión bibliográfica utilizando el método PRISMA, revisando quince artículos relevantes para proporcionar una visión integral del tema. La investigación incluyó la evaluación de estudios sobre el uso de IA en la educación matemática, desde técnicas de modelado hasta estrategias didácticas innovadoras. Los hallazgos principales muestran que la IA contribuye significativamente a una enseñanza más adaptativa y personalizada, mejorando el compromiso y el rendimiento académico de los estudiantes. No obstante, también se identificaron limitaciones, como la falta de estudios en contextos específicos y la necesidad de investigaciones más profundas para comprender mejor los efectos a largo plazo. La revisión subraya que, aunque la IA ofrece grandes promesas para la educación matemática en entornos virtuales, es esencial continuar investigando y abordando los desafíos asociados para maximizar sus beneficios. Esta investigación resalta cómo la integración de la IA puede revolucionar la enseñanza de matemáticas, al mismo tiempo que sugiere áreas clave para futuras investigaciones que podrían impulsar aún más la efectividad de estas tecnologías en la educación.
Ensuring Linguistic Sustainability in Bangladesh: Challenges and Approaches. Part II
Authors: Awal Abdul
Published: September 2024

This study investigates the obstacles to language sustainability in Bangladesh, which boasts a wealth of linguistic diversity, and proposes a comprehensive plan to support this variety. The study begins with an examination of Bangladesh’s linguistic demographics, highlighting the multitude of languages spoken by the country’s various ethnic communities. It then delves into the historical context of language movements in Bangladesh and illustrates how language serves as a crucial marker of identity and unity. Subsequently, this research explores the socioeconomic, political, and educational factors that contribute to language endangerment and change. It discusses the consequences of these changes on cultural identity, transmission of knowledge, and community well-being. This study proposes a comprehensive framework for language sustainability in Bangladesh, emphasising five key components: documentation and revitalisation of endangered languages, implementation of comprehensive multilingual education policies, utilisation of modern technology in language preservation, promotion of cross-cultural understanding through exchange programs, and national policy support for language rights and diversity. These initiatives aim to enhance linguistic sustainability, foster social cohesion, and empower marginalised communities. This study argues that by addressing these challenges and adopting these strategies, Bangladesh can secure a sustainable linguistic future and preserve its diverse cultural heritage.
“Golden Ruby” in Chișinău, in the 20s of the 19th century
Authors: Grabovscaia Valentina
Published: September 2024

The purpose of this work is the history of the creation of the unique “golden ruby”, ruby glass colored with gold nanoparticles in various shades of pink, red, crimson and purple, the recipe of which was kept in the strictest confidence for centuries. The oldest piece of ruby glass is considered to be the Lycurgus Cup, located in the British Museum, presumably created in the 4th century AD, associated with the Alexandrian culture. It is surprising that in the early 1820s of the 19th century in Chișinău it was possible to purchase objects made from this precious glass. It is known that A.S. Pushkin in 1822, bought a ruby glass travel set at the Ilyinsky Bazaar, consisting of a tray, a decanter and four glasses, and treasured it as a memory of Chișinău. In 1828, Alexander Sergeevich presented this set to his older sister Olga on her wedding day, filling the decanter with his favorite Moldavian Madeira wine, diluted with water, as the Greeks did. The set was miraculously partially preserved and is now located in St. Petersburg, in the poet’s last Apartment-Museum on Moika Embankment, 12. In memory of the poet in the exhibition of the A.S. House Museum А.S. Pushkin in Chișinău presented a set of ruby glass, but for spices, consisting of four items: a salt shaker, a pepper shaker, a vinegar shaker, dating back to the beginning of the 19th century, which is of historical and literary value.
Application of crisis management in crisis management in Kosovo and Metohia
Authors: Draganović Mile , Gligović Dejan
Published: September 2024

Defining and managing the crisis in Kosovo and Metohija brings with it controversy for many political factors, in the sense that today there is no consensus on the domestic political level (even among the subjects of the international community). There are serious disagreements regarding the classification of the crisis in Kosovo and Metohija, in fact its political, legal and security determination. Due to the resulting political changes and trends, in everyday terminology, many terms, ideological concepts, and even real facts are avoided when talking about the problem of Kosovo and Metohija. This paper is an attempt to contribute to a multidimensional definition of the crisis in Kosovo and Metohija and an adequate response to it.
Neuroticism, coping styles and psychological distress among frontliners during COVID-19 pandemic in Kelantan, Malaysia
Authors: Chidambar Subramanian Barath , Shafini Bakar Raishan , Che Rahimi Aisyah , Mohd Yasin Mohd Azhar
Published: September 2024

The study aimed to determine the prevalence of psychological distress and explore the roles of neuroticism traits and coping styles among frontliners during the COVID-19 pandemic in Malaysia.  A total of 336 frontline healthcare workers from three COVID-19 hospitals in Malaysia participated in the online survey. The measurements, including sociodemographic characteristics, presence of psychological distress, neuroticism traits, and coping styles, were assessed using the sociodemographic proforma, General Health Questionnaire (GHQ-12), Big Five Inventory, and Brief COPE scales.Descriptive analysis with SPSS-26 were performed to determine the socio-demographic attributes of the participants, level of trait neuroticism, coping styles and psychological distress. Multiple logistic regression analysis was carried out to determine the factors significantly associated with psychological distress.Results showed that out of 336 frontliners, 22.9% reported psychological distress. Higher trait neuroticism was significantly associated with an increased risk of psychological distress (p < 0.05), while religious coping was significantly associated with a decreased risk of psychological distress (p < 0.05). Other sociodemographic factors, such as age, gender, and years of experience, did not show significant associations with psychological distress.The high prevalence of psychological distress among frontliners highlights the importance of addressing their mental health needs during pandemics. Interventions aimed at enhancing psychological well-being should consider targeting neuroticism traits and promoting adaptive coping strategies, such as religious coping.
Patogenesitas blastospora dan konidia Lecanicillium lecanii Zare & Gams terhadap Helopeltis bradyi Waterhouse (Hemiptera: Miridae)
Authors:   Departemen Proteksi Tanaman, Fakultas Pertanian, IPB University, Indonesia, Azhari Ahmad Alwi , Anwar Rully ,   Departemen Proteksi Tanaman, Fakultas Pertanian, IPB University, Indonesia, Sartiami Dewi ,   Departemen Proteksi Tanaman, Fakultas Pertanian, IPB University, Indonesia, Samsudin Samsudin ,   Badan Riset dan Inovasi Nasional, Pusat Riset Hortikultura dan Perkebunan, Indonesia
Published: September 2024

Helopeltis bradyi, merupakan salah satu hama perkebunan teh yang menyebabkan kerusakan hingga penurunan hasil produksi tanaman. Cendawan Lecanicillium lecanii sebagai musuh alami merupakan pengendalian alternatif yang telah diteliti untuk menekan perkembangan dan populasi H. bradyi. Penelitian bertujuan mengetahui patogenesitas blastospora dan konidia terhadap mortalitas, serta dampaknya terhadap kemampuan makan dan reproduksi H. bradyi. Penelitian menggunakan rancangan acak lengkap dengan sepuluh perlakuan dan lima ulangan, termasuk kontrol positif (insektisida deltametrin), kontrol negatif (akuades), serta konsentrasi blastospora (2,45 × 106 hingga 2,45 × 109 blastospora/ml) dan konidia (2,78 × 106 hingga 2,78 × 109 konidia/ml) L. lecanii. Hasil penelitian menunjukkan bahwa L. lecanii dengan konsentrasi 2,78 × 109 konidia/ml menyebabkan kematian H. bradyi sebesar 86% dan rata-rata 223,89 tusukan pada 7 hari setelah aplikasi. LC50 dan LT50 konidia L. lecanii lebih rendah, yaitu 6,62 × 105 konidia/ml dan 4,44 hari dibandingkan dengan blastospora, yaitu 2,20 × 107 blastospora/ml dan 5,37 hari. Aplikasi L. lecanii dengan konsentrasi 2,45 × 109 blastospora/ml menghasilkan jumlah telur terendah, yaitu 5,40 butir. Blastospora maupun konidia L. lecanii terbukti efektif dalam mengendalikan H. bradyi. Konidia memberikan hasil terbaik dalam mortalitas dan pengurangan aktivitas makan nimfa instar III, sementara blastospora juga efektif meskipun dengan hasil yang sedikit lebih rendah. Hasil penelitian ini menunjukkan L. lecanii dapat menjadi alternatif pengendalian hama yang ramah lingkungan dan berkelanjutan dibandingkan insektisida sintetik.
The Impact of Implementing Total Quality Management on Customer Satisfaction: An Applied Study on Al Rajhi Cooperative Insurance Company
Authors: Al Othman Kholoud
Published: September 2024

The aim of the study is to determine the impact of applying Total Quality Management with its dimensions (employee participation, training, continuous improvement, senior management support, customer focus) on customer satisfaction in the application of Al Rajhi Cooperative Insurance Company. The study relied on the descriptive analytical approach, and the study sample amounted to (70) employees of Al Rajhi Cooperative Insurance Company, and (80) customers. The results of the study indicate that Total Quality Management (TQM) plays a crucial role in enhancing customer satisfaction in Al Rajhi Cooperative Insurance Company, as the results showed that the various dimensions of Total Quality Management, such as continuous improvement, training, senior management support, and customer focus, positively affect customer satisfaction. A clear statistical significance was observed for the contribution of these dimensions to improving the level of customer satisfaction, which enhances the effectiveness of applying Total Quality Management in achieving positive results in the company's overall performance.
The Reality of Using Interactive Multimedia in Teaching Digital Technology to High School Students
Authors: Al-Zahrani Wael , Al-Bishri Badr
Published: September 2024

The study aimed to identify interactive multimedia, understand the reality of using interactive multimedia in teaching digital technology from the perspective of secondary school digital technology teachers, and uncover the challenges of using interactive multimedia in teaching digital technology from the perspective of secondary school digital technology teachers. The study used a descriptive approach according to the nature and objectives of the research. The reality of using interactive multimedia in teaching digital technology for secondary school was studied. The research sample consisted of 156 teachers of digital technology for secondary school under the supervision of the Education Administration in Al-Madinah Al-Munawwarah. A questionnaire tool was used to measure the reality of using interactive multimedia. The study found that the frequencies, percentages, means, and standard deviations regarding the reality of using interactive multimedia in teaching digital technology from the teachers' perspective ranged from (4.12) to (0.88). The results of this study indicate that teachers emphasized the importance of these skills and the necessity of dealing with interactive multimedia. The reality of their use of interactive multimedia is considered limited and does not achieve the desired goals. The study sample also pointed out the challenges associated with the use of interactive multimedia, such as technical, human, and material challenges.
NCCN Guidelines® Insights: Colorectal Cancer Screening, Version 1.2024
Authors: Ness Reid M. , Llor Xavier , Abbass Mohammad Ali , Bishu Shrinivas , Chen Christopher T. , Cooper Gregory , Early Dayna S. , Friedman Mark , Fudman David , Giardiello Francis M. , Glaser Kathryn , Gurudu Surya , Hall Michael , Huang Lyen C. , Issaka Rachel , Katona Bryson , Kidambi Trilokesh , Lazenby Audrey J. , Maratt Jennifer , Markowitz Arnold J. , Marsano Joseph , May Folasade P. , Mayer Robert J. , Olortegui Kinga , Patel Swati , Peter Shajan , Porter Laura D. , Shafi Mehnaz , Stanich Peter P. , Terdiman Jonathan , Vu Peter , Weiss Jennifer M. , Wood Elizabeth , Cassara Carly J. , Sambandam Vaishnavi
Published: September 2024

The NCCN Guidelines for Colorectal Cancer (CRC) Screening describe various colorectal screening modalities as well as recommended screening schedules for patients at average or increased risk of developing sporadic CRC. They are intended to aid physicians with clinical decision-making regarding CRC screening for patients without defined genetic syndromes. These NCCN Guidelines Insights focus on select recent updates to the NCCN Guidelines, including a section on primary and secondary CRC prevention, and provide context for the panel’s recommendations regarding the age at which to initiate screening in average-risk individuals and those with increased risk based on personal history of childhood, adolescent, and young adult cancer.
Global Perspectives on the Social Impacts of Artificial Intelligence: A Comparative Review of Regional Inequalities and Cultural Contexts
Authors: Akter Sohana
Published: September 2024

The ethical implications and social impacts of artificial intelligence (AI) have garnered significant interest from industry, academia, and the public. However, global analyses of AI are often biased towards U.S. perspectives and are constrained by a lack of research, particularly outside the U.S. and Western Europe. This article presents key findings from a comprehensive literature review of recent social science research on the social impacts of AI and related technologies across five global regions. Our team of social scientists examined over 800 academic journal articles and monographs in more than a dozen languages. The review indicates that AI’s social impacts are likely to vary significantly by geographical setting, with local cultural and social contexts profoundly influencing perceptions and understandings of AI.Research from U.S. contexts shows that AI-driven technologies frequently reinforce social divides and exacerbate inequality, especially among historically marginalized groups. Our review suggests that this pattern is evident globally, with low- and middle-income countries potentially facing greater vulnerability to the negative impacts of AI while being less likely to reap its benefits.We advocate for rigorous ethnographic research to enhance our understanding of AI’s social impacts worldwide. In-depth, localized research is essential to identify AI systems that may exacerbate social inequality and to devise strategies to mitigate potential harms. A deeper understanding of AI’s social impacts in diverse settings is crucial for the responsible development, implementation, and regulation of these technologies, ensuring they contribute positively to society.
‹‹Han de tener de la una parte y de la otra plus Vltra››. Nuevas aproximaciones sobre Jerónimo de Orlando, tenedor de las tiendas de campaña al servicio de Carlos V (1535 – 1548)
Authors: Cubero Bujalance Julio Manuel
Published: September 2024

El presente trabajo aborda las tiendas de campaña realizadas para la empresa de Túnez (1535) y de Argel (1541), principalmente a partir de documentación conservada en el Archivo General de Simancas referentes a la segunda jornada, en la que se incluye una descripción acompañada de un bosquejo inédito de Jerónimo de Orlando, tenedor de los pabellones y tiendas de campaña de Carlos V. Gracias al esquema y al cotejo entre la correspondencia y las notas de gastos podemos aproximarnos a los materiales, colores y divisas con que se conformaban.
Adenocarcinoma gástrico intramucoso en colon originado de una heterotopia gástrica: reporte de un caso y revisión de la literatura
Authors: Peraza Simon , Castro Denny , Silva Olga , Becerra Vanessa
Published: September 2024

La heterotopia gástrica se define como la presencia de tejido ectópico fuera de su ubicación normal, pudiendo encontrarse en varios niveles del tracto gastrointestinal, incluyendo el tracto biliar y páncreas. El riesgo de adenocarcinoma no se encuentra bien establecido debido a lo poco usual de esta lesión. El presente caso trata de paciente femenina de 54 años de edad, quien refiere de larga data dolor abdominal localizado en flanco izquierdo, el cual exacerbó en las últimas semanas. Se realiza colonoscopia en la cual en colon descendente se observa pólipo sésil, de aproximadamente 1 cm de diámetro, de superficie lisa, sin cambios vasculares ni glándulares y se reseca con asa fría. Este pólipo es reportado por anatomía patológica como una mucosa gástrica tipo pilórica con área neoplásica maligna epitelial cuyos marcadores de inmunohistoquimica fueron positivos para CK7, CDX2, AE1/AE3 y Ki67, concluyendo entonces como adenocarcinoma gástrico Intramucoso originado en heterotopia gástrica poilipoide de colon descendente. Actualmente la paciente se encuentra asintomática
Hamartoma hepático más nódulo necrótico solitario: reporte de un caso y revisión de la literatura
Authors: Becerra Vanessa , Lizcano Luz , Rivera Angel , Peraza Simón , Carreño Luz , Silva Olga , Castro Denny
Published: September 2024

Los complejos de Von Meyenburg son hamartomas que surgen de los conductos biliares intrahepáticos. Las lesiones sintomáticas son poco comunes y las lesiones gigantes son extremadamente raras y al encontrarlas deben ser resecadas, ya que hay informes de transformación maligna. Presentamos el caso de paciente femenina de 68 años de edad, quien refiere de 06 meses de evolución aumento progresivo del perímetro abdominal, asociado a dolor localizado en hipocondrio derecho, de carácter opresivo, moderada intensidad, no irradiado; asociado a saciedad precoz. En hemiabdomen derecho impresiona aumento de volumen, se palpa masa ovalada de aproximadamente 15 x 15 cm, blanda, depresible, no dolorosa, no pulsátil. Ecográficamente se observa en hígado (segmentos II y III), lesión quística, bien delimitada, de contenido homogéneo, de 14 x 15 x 17 cm de diámetro y tomograficamente, una imagen gigante, ovalada, con coeficiente de atenuación en rango líquido. Se realiza quistectomía hepática cuyos hallazgos anatomopatológicos reportan quiste biliar hepático y nódulo necrótico solitario.
Intususcepción por adenocarcinoma mucinoso del apéndice cecal. A propósito de un caso
Authors: Chaurán María , Diaz Uslar , Rodriguez Vanessa
Published: September 2024

Objetivo: Evaluar la eficacia de la rehabilitación anorrectal guiado con manometría de alta resolución en mujeres con incontinencia fecal que acudieron a la Unidad de Motilidad Digestiva y Neurogastroenterología del Hospital de Clínicas Caracas Métodos: Estudio prospectivo, comparativo y longitudinal, que incluyó 13 pacientes con diagnóstico de incontinencia fecal, se comparó la escala de Wexner antes y después de la rehabilitación, se realizó la comparación de los valores de la presión de contracción sostenida antes y después, y se relacionaron las variables de la manometría de alta resolución (presión basal, presión de contracción sostenida, sensibilidad anorrectal) con la mejoría clínica de las pacientes posterior a la rehabilitación. Se consideró un contraste estadísticamente significativo si p<0,05. Resultados: Para las 13 pacientes el rango etario comprendió desde los 32 hasta los 93 años de edad, el 50 % se encontraron por encima de los 67 años. La presión de contracción sostenida antes y después: 118,79 ± 83,497 mmHg y 131,56 ± 89,006 mmHg respectivamente, p=0.0002. Primer deseo antes y después: 48,462 ± 49,64 ml y 30,00 ± 39,158 ml, p=0.0042. La media para el puntaje de la escala de Wexner antes y después fue de 13,385 ± 4,1541 y 5,4615 ± 5,4561 puntos respectivamente, p=0.0036. El puntaje de incontinencia mayor antes y después obtuvo una media de 1,07 ± 0,3997 y 0,6154 ± 0,3309 puntos, p=0.0195; para incontinencia menor a líquidos antes y después: 3,3077 ± 0,3649 y 1,3077 ± 0,3279 puntos, p=0.0018 y para incontinencia menor a gases antes y después: 2,138 ± 0,5412 y 1,0769 ± 0,3662 puntos, p=0.0124. La relación entre pacientes con y sin neuropatía del nervio pudendo y la mejoría clínica después de la rehabilitación expone que el 100 % de las pacientes con neuropatía mejoraron clínicamente y el 87,5 % de las pacientes sin neuropatía, p=0.4106 (no significativo). Al relacionar las pacientes con y sin neuropatía del nervio pudendo con la mejoría de la sensibilidad rectal (primer deseo) después de la rehabilitación se obtuvo que el 100 % de las pacientes con neuropatía mejoraron la sensibilidad y el 75 % de las pacientes sin neuropatía, p=0.2242 (no significativo). Conclusiones: La rehabilitación anorrectal guiada con manometría de alta resolución mejora los síntomas de la incontinencia fecal, mejora los 3 tipos de incontinencia (a sólidos, líquidos y gases) y mejora la calidad de vida de las pacientes. Además aumenta de forma significativa la presión de contracción sostenida, mejora la sensibilidad rectal (primer deseo) y la mejoría clínica se presenta independientemente si existe o no el diagnóstico asociado de neuropatía del nervio pudendo.
Linfoma de esófago. Presentación de un caso clínico y revisión de la literatura
Authors: Pinto Angélica , Torrealba Lilibeth
Published: September 2024

Introducción: El linfoma primario difuso de células B (LDCBG) de esófago es una variedad rara de linfoma no Hodgkin. Reportamos un caso en una paciente del sexo femenino de 36 años de edad, surgido de nuestra experiencia clínica. Además, se realiza una revisión de los casos reportados durante los últimos 5 años. Materiales y métodos: Se llevó a cabo una búsqueda de casos publicados en la base de datos PubMed. Los datos sobre las características clínico-epidemiológicas de los pacientes, así como de las investigaciones diagnósticas y sus resultados se analizaron. Resultados: Se incluyeron un total de 6 artículos que reportan casos individuales. La mayoría de los casos reportados son en pacientes del sexo femenino, con un amplio rango de edades, quienes no tenían antecedentes de inmunodeficiencia. Los principales síntomas fueron pérdida de peso y disfagia. Así mismo, las lesiones encontradas en la endoscopia digestiva superior dadas por una lesión o masa que estenosa la luz esofágica suelen ser los más comunes, al igual que el engrosamiento circunferencial demostrado en la tomografía. En muchos de los casos, los resultados de la biopsia no fueron concluyentes por lo que se ameritó la realización de inmunohistoquímica. Discusión y comentario: Esta revisión, así como nuestro caso, demuestra algunas características que escapan a lo tradicionalmente descrito en la literatura. Conclusiones: A pesar de su poca frecuencia, se debe mantener esta patología en mente como probable posibilidad diagnóstica en todo paciente que se presente con síntomas y signos de malignidad esofágica.
Aplicación de minería de datos en la empresa Innovate Consulting para predecir valores de ventas
Authors: Falconí Punguil Diego Geovanny , Tello Oña Yomara Elizabeth , Calvopiña Oña Martha Patricia
Published: September 2024

El presente artículo presenta un estudio sobre la aplicación de minería de datos en Innovate Consulting para predecir valores de ventas. El objetivo fue comparar la capacidad predictiva de tres modelos principales: Random Forest, Deep Learning y Naive Bayes. Para ello, se implementó un método que incluyó el procesamiento de datos históricos de ventas, la configuración y entrenamiento de los modelos de Machine Learning, y la evaluación de su precisión mediante una matriz comparativa. Los resultados destacaron que Random Forest mostró la mayor precisión, seguido por Deep Learning y Naive Bayes. Estos hallazgos subrayan la importancia de seleccionar el modelo adecuado según las características específicas del conjunto de datos, proporcionando una base sólida para mejorar la planificación estratégica y la toma de decisiones.
Uji Aktivitas Antihipertensi Seduhan Rambut Jagung (Zea mays L.) Terhadap Mencit Jantan Galur Swiss Webster
Authors: Septiyan Taufik , Dewi Lisna , Saepudin Syumillah , Rahayu Iseu
Published: September 2024

Hipertensi atau tekanan darah tinggi adalah suatu keadaan kronis dengan meningkatnya tekanan darah pada dinding pembuluh darah arteri. Hipertensi ditandai dengan terjadinya peningkatan tekanan darah yang tidak normal dan menetap pada beberapa kali pengukuran tekanan darah yang disebabkan oleh satu atau lebih faktor risiko yang tidak bekerja dengan baik untuk mempertahankan tekanan darah normal. Salah satu tumbuhan yang dimanfaatkan dalam pengobatan tradisional adalah rambut jagung (Zea Mays L.) umumnya digunakan oleh masyarakat sebagai obat herbal dengan cara diseduh. Bagian tanaman ini mengandung banyak manfaat karena mengandung senyawa metabolit seperti flavonoid yang berperan sebagai antioksidan. Uji aktivitas antihipertensi dilakukan dengan induksi NaCl 2% dengan cara oral serta mengukur tekanan darah menggunakan metode non-invasive Blood Pressure dengan alat Mice rat blood pressure IT science terhadap mencit. Respon antihipertensi ditandai dengan meningkatnya tekanan darah hewan uji. Seduhan rambut jagung dengan dosis 2, 4 dan 6 gram memiliki efek antihipertensi terhadap mencit jantan galur Swiss webster. Seduhan rambut jagung yang paling berpengaruh terdapat pada seduhan rambut jagung dengan dosis 4 gram (dosis 2) karena dosis tersebut memberikan pengaruh yang paling mendekati obat amlodipin. Seduhan rambut jagung memiliki kadar flavonoid sebesar 5,366 mg/L dan kadar alkaloid yang didapatkan sebesar 1,176 mg/L.
 
Kata Kunci: Hipertensi; Rambut jagung; NaCl; Mencit; Non-invasive Blood Pressure.
Optimasi Formula Sediaan Emulgel Minyak Nimba (Azadirachta indica) menggunakan Response Surface Methodology
Authors: Akmal Tubagus , Yunus Mohammad
Published: September 2024

Neem oil possesses numerous advantages for skin health due to its properties as an antioxidant, antibacterial, antifungal, and wound-healing agent when used topically. Neem oil, due to its numerous advantages for the skin, can be used in cosmetic products, such as emulgel preparations. The objective of this study is to enhance the formulation of neem oil emulgel by adjusting the concentration of olivem 1000 (X1) as an emulsifier and xanthan gum (X2) and guar gum (X3) as gelling agents. Formula optimization was conducted utilizing the Box Behnken Design method in Design Expert v.13.0.1 software. The test responses measured were viscosity (Y1) and pH (Y2). The test yielded 15 test formulations with viscosity and pH values ranging from 12800 ± 505.96 to 66400 ± 438.18 cPs and from 4.67 ± 0.01 to 5.01 ± 0.01, respectively. The study concludes that the optimum formula is achieved by using a concentration of olivem 1000, xanthan gum, and guar gum at 5.00, 0.1, and 0.5, respectively. This formula has a viscosity value of 42600 ± 419.5 cPs and a pH of 4.94 ± 0.1.
Evaluasi Peresepan Obat Penanganan COVID-19 Pada Pasien Geriatri di Rawat Inap Salah Satu Rumah Sakit di Kabupaten Bandung
Authors: Yane Srie Herliany  , Fitriyana Anna
Published: September 2024

Penyakit coronavirus 2019 (COVID-19) merupakan infeksi saluran pernapasan yang disebabkan oleh coronavirus. Penatalaksanaan klinis dilakukan pada pasien COVID-19 tanpa gejala, sakit ringan, sakit sedang, sakit berat, kondisi kritis, dan pada kondisi tertentu. Tujuan penelitian ini adalah untuk mengetahui peresepan obat dalam penanganan COVID-19 pada pasien geriatri yang termasuk kelompok Pasien Dalam Pengawasan (PDP) di rawat inap salah satu rumah sakit Kabupaten Bandung. Penelitian ini merupakan penelitian non-eksperimental yang dirancang secara deskriptif dengan metode kuantitatif yang bersifat retrospektif. Data penelitian diambil selama periode Maret-September 2020 sebanyak 116 lembar resep yang memenuhi kriteria inklusi. Hasil penelitian ini menunjukkan dokter paling banyak meresepkan obat antibiotik azithromicin 500 mg tab (19%). Obat lain yang diresepkan antara lain suplemen vitamin C tablet, levofloxacin 500mg tab, levofloxacin 500 mg infus, oseltamivir kapsul, chloroquin tablet, acetylcysteine tablet, Suplemen prove d3 1000 IU tablet, Zinc tab, parasetamol tablet, meropenem injeksi, cefotaxim injeksi, dan methysoprinol tablet. Interaksi obat ditemukan sebanyak 80% dari total sampel, dengan tingkat keparahan minor sebanyak 14%, moderate sebanyak 66% dan mayor sebanyak 20%.
 
Kata Kunci: COVID-19;Geriatri;Resep;Rumah sakit;Rawat Inap
Association of Musculoskeletal Pain with Poor Quality of Sleep Among E-Gamers in a Private University in Malaysia
Authors: Nyamupanemunda Larry , Arrova Dewi Deshinta
Published: September 2024

Background: Electronic sports (e-sports) requires prolonged sitting and repetitive movements which makes e-gamers susceptible to develop musculoskeletal pain in different body parts. Moreover, their quality of sleep may also be affected. It is very important for physiotherapist to identify the relationship between musculoskeletal pain and poor quality of sleep among e-gamers, so as to develop more precise treatment plan and provide higher quality of patient education. Objective: The purpose of this study was to analyse the association between musculoskeletal pain with poor quality of sleep among e-gamers in a private university in Malaysia. Methodology: The sample consisted of 42 e-gamers from a private university in Malaysia. A cross-sectional study was conducted by using Nordic Musculoskeletal Questionnaire and Sleep Quality Scale. The association between musculoskeletal pain and poor sleep quality was evaluated using chi-square test. Results: The results showed that more than half of the study population reported with a higher prevalence of neck pain in the past year and in the previous week, followed by shoulders, wrists and hands. Besides, half of the participants also reported that they had very poor sleep quality (50%), followed by the category of poor quality of sleep (23.8%). E-gamers with poor sleep quality showed significant association with musculoskeletal pain in neck (p= 0.004), shoulder (p= 0.052), upper back (p=0.043), wrist and hands (p= 0.004). Conclusion: Our findings revealed that musculoskeletal pain in neck, shoulder, upper back, wrist and hands was significantly associated with poor sleep quality among e-gamers. Health promotion actions that contribute towards improvement in quality of sleep and prevention of musculoskeletal pain should be considered, so the performance and quality of life among the e-gamers could be improved.
Customer Satisfaction on Public Transportation in Penang, Malaysia
Authors: Tharmalingam Sobanah Dhevi , Sai Mei Ling , Vija-Kumaran Vikniswari , Kalimuthu Kalai Vani , Nodeson Suresh
Published: September 2024

This paper reports the customers’ satisfaction about public transportation service in Penang, Malaysia. In this respect, some of the factors namely reliability, accessibility, safety and security are used to measure the customers’ satisfaction on bus service Rapid Penang, Malaysia. A survey was conducted where questionnaires were distributed to 500 bus passengers. The results of the study indicates that reliability, accessibility, safety and security of bus service are positively significant to customer satisfaction. The contribution of the study creates better understanding of the service provider the factors that able increase customers’ satisfaction and base on the knowledge they able to improve their services and gain the customers’ trust.