bluuebunny/crossref_metadata_2025 huggingface dataset:
Sindrom Kartagener pada perempuan dewasa: sebuah laporan kasus langka
Authors: Ida Ayu Devi Ariani , Widyaningsih Putu Dyah
Published: September 2024

Background: Kartagener’s syndrome, a rare autosomal recessive genetic cilia disorder, is a triad condition consisting of situs inversus, chronic sinusitis, and bronchiectasis. Kartagener’s syndrome has caused a frequency of 1 in 30,000–40,000 live births. This case report aims to present a 28-year-old female with Kartagener syndrome.
Case presentation: A 28-year-old female with chief complaints of coughing, runny nose, and dyspnea that had been occurring for the previous two months. The patient underwent surgery for sinusitis. The patient's biological father has a history of asthma, according to the patient's family history. On clinical and radiographic evaluation, situs inversus, bronchiectasis, and chronic sinusitis were found. Patient was treated with oral antibiotics, inhaled bronchodilators, mucolytics, oral capsules containing corticosteroids, antihistamines, and bronchodilators, sprays of corticosteroids, isotonic fluids, sinus irrigation, and polypectomy. The patient's prognosis was dubia ad malam.
Conclusion: Patient with Kartagener syndrome often present with persistent, recurrent sinopulmonary symptoms due to inadequate mucociliary clearance, patients. Primary objectives of patient therapy are preventing the course of the disease, preserving lung function, and improving the patient's quality of life.
 
Latar belakang: Sindrom Kartagener adalah kelainan silia genetik resesif autosomal langka yang terdiri dari trias (situs inversus, sinusitis kronis, dan bronkiektasis). Sindrom Kartagener merupakan subkelompok Diskinesia Silia Primer dengan insiden 1 dari 30.000-40.000 kelahiran hidup. Struktur atau fungsi silia yang abnormal menyebabkan gangguan motilitas Silia. Diagnosis dini pada awal kehidupan sangat penting untuk mencegah komplikasi dan meningkatkan kualitas hidup.
Presentasi kasus: Seorang wanita berusia 28 tahun dengan keluhan utama batuk, pilek, dan sesak napas yang terjadi sejak dua bulan sebelumnya. pasien menjalani operasi untuk sinusitis. Ayah kandung pasien mempunyai riwayat penyakit asma, sesuai dengan riwayat keluarga pasien. Pada evaluasi klinis dan radiografi ditemukan situs inversus, bronkiektasis, dan sinusitis kronis. Pasien diterapi dengan antibiotik oral, bronkodilator inhalasi, mukolitik, kapsul oral yang mengandung kortikosteroid, antihistamin, dan bronkodilator, semprotan kortikosteroid, cairan isotonik, irigasi sinus, dan polipektomi. Prognosis pasien adalah dubia ad malam.
Simpulan: Pasien dengan sindrom Kartagener sering mengalami gejala sinopulmoner yang persisten dan berulang karena klirens mukosiliar yang tidak cukup. Tujuan utama terapi yaitu mencegah perjalanan penyakit, menjaga fungsi paru-paru, dan meningkatkan kualitas hidup pasien.
Hybrid halide perovskites, a game changer for future solar energy?
Authors: Faini Fabiola , Larini Valentina , Scardina Alice , Grancini Giulia
Published: September 2024

Hybrid halide perovskites (HPs) are emerging as the most promising materials for near-future photovoltaics (PV) due to their unique optoelectronic properties, such as their low defect density and broad absorption, making them highly efficient photoactive materials. Meanwhile, their low cost and low embodied energy, together with their solution processability and the possibility to create solar cells on flexible substrates, make them among the potential winning concepts for the next-generation PV market. Large-scale marketing, however, requires solving current challenges, which mainly relate to device longevity and scaling up. In this article, we put in perspective the key aspects of HP materials and HP-solar cells, briefly discussing their historical path to high efficiency, reviewing the state of the art, presenting their main advantages over existing technologies, and the main challenges the research community needs to overcome. Recent achievements and hot areas today critical for market uptake will be presented.

Graphical abstract
Improving linear programming model for assessing product sales taking into account social responsibility of consumers
Authors: Potrashkova Liudmyla
Published: September 2024

The object of this study is the process of analyzing the volume of product sales in the retail market, where producers and consumers with different levels of social responsibility operate. Advancements are aimed at solving the problem of insufficient consideration of the social responsibility of economic entities in modern economic and mathematical models. In the work, the improvement of the linear programming model, intended for the evaluation of sales of alternative variants of goods with different social utility to consumers with different social responsibility, by taking into account some real conditions of making purchases, was carried out. As a result of the study, a modification of the model was proposed that makes it possible to take into account the behavior of buyers who choose a product randomly. Also, with the help of additional restrictions, the model takes into account the fact that consumers with different social responsibility make purchases in parallel in time. In addition, the approach to identifying a set of consumer groups in the aspect of social responsibility using the method of questionnaires of the ranking type and building a decision tree of consumers is described.
The proposed modification of the model was tested on the example of evaluating the sales volumes of environmentally-friendly and non-environmentally-friendly varieties of goods in the office paper market. It is shown that not taking into account the added restrictions in the model could significantly affect the estimates of sales volumes.
The proposed improvements to the model make it possible to obtain more realistic estimates of the volume of sales of goods, taking into account the social responsibility of consumers, as well as quantitative and qualitative characteristics of competitors’ offers. This contributes to better decision-making support for manufacturing socially useful products, in particular, environmentally-friendly ones
Key stages of adapting the acquis communautaire to Ukraine's legal system: a historical overview
Authors: Rastorhuieva Nataliia
Published: September 2024

The article is aimed at clarifying the status of regulatory and legal support for the process of adaptation of the national legislation to the acquis communautaire. It is stated that the Ukrainian state has already completed most of the steps to join the EU. Attention is focused on the relevance of the study, which is due to Ukraine's officially obtaining the EU candidate status and the transition to the negotiation process between the EU and Ukraine on the latter's accession to the EU.
The author analyses the provisions of Ukrainian legislation and scientific research on the understanding of the concept of ‘acquis communautaire’. The author's definition of this legal phenomenon is formulated, which should be understood as the sources of EU law, standards, principles of external and internal activities and other achievements of the European Communities.
The author's own approach to distinguishing four stages of adaptation of the national legislation to the acquis communautaire in chronological order is proposed. The first stage was when Ukrainian legislation implemented the EU norms and standards to establish economic cooperation between Ukraine and the EU in various areas for the development of various relations between the partners. The second stage was a testament to the irresistible desire of Ukraine and Ukrainians to be part of the EU community and contributed to the signing and entry into force of the EU-Ukraine Association Agreement. The third stage demonstrates Ukraine's path from the signing of the EU-Ukraine Association Agreement to the EU candidate status. The fourth stage is connected with the European Council's announcement of the start of negotiations with Ukraine on the country's accession to the EU and the need for comprehensive harmonisation and adaptation of Ukrainian legislation to the EU acquis in connection with the prospect of EU membership.
It is emphasised that the implementation of the acquis communautaire into the national legal system should pursue national interests and be a political, economic, legal and social consensus on key issues of European integration transformations
Szkoła w dyskursie polskich kabaretów
Authors:   Uniwersytet Mikołaja Kopernika w Toruniu, Polska, Kopińska Violetta , Lewartowicz Urszula ,   Uniwersytet Marii Curie-Skłodowskiej w Lublinie, Polska
Published: September 2024

The study aims to identify problems related to school and school education present in cabaret discourse and the way they are presented. The cabaret is an interesting research area and field of analysis of social problems, including issues related to educational policy. The data collection method was source searching. The analytical material consisted of eight sketches of Polish cabarets, selected according to the criteria: time of publication, popularity, and topicality. The data analysis method belongs to a group of approaches called critical discourse analysis. Applications of discursive strategies described by R. Wodak and M. Reisigl were sought. The results show that in the discourse of Polish cabarets, the school is presented as a subordinate contractor of political and legal regulations. It characterises with low social prestige, which is built on the low assessment of school teaching in terms of content, the low prestige of the teaching profession, and the low assessment of the student’s role. In relations between these entities, the discourse of scolding and disciplining appears as the manifestation of power and hierarchy; of infantilisation and sexism.
Artyści sztuki iluzji, aktorzy teatralni i ich poczucie jakości życia
Authors:   Uniwersytet Jana Długosza, Polska, Napora Wojciech
Published: September 2024

The sense of quality of life is a subjective attitude towards the assessment of satisfaction with one’s own life. They can be divided into four spheres: psychophysical, psychosocial, subjective, and metaphysical. 210 people participated in the study – 53 illusionists, 52 theater actors, and 105 people who did not engage in activities related to public appearances. The groups were compared in terms of the sense of quality of life, and the study used the Sense of Life Quality Questionnaire by Straś-Romanowska, Oleszkowicz, and Frąckowiak (2004) in a modified version by Mróz et al. (2017). Theater actors and magicians had a higher level of satisfaction with the psychosocial sphere and a general level of quality of life compared to the control group (which has neither experience nor education related to stage performance). In terms of the psychophysical and metaphysical spheres of the sense of quality of life, theater actors were characterised by a higher level of satisfaction compared to people who did not engage in stage activity. In the conducted study, no statistically significant differences between groups were observed in relation to the subjective sphere of the sense of quality of life.
Surgical treatment of aortic root abscess: 10-year single center experience
Authors: Enginoev S. T. , Zenkov A. A. , Magomedov G. M. , Abdulmejidova U. K. , Guliyev M. A. , Chernov I. I. , Gubareva E. Yu.
Published: September 2024

The issue of optimal surgical scope in patients with aortic root abscess due to infective endocarditis remains open, since there are different strategies and interventional methods. In addition, the guidelines do not give preference to any particular type of surgical intervention and recommend an individual approach to each situation. The study included 25 patients with aortic root abscess due to aortic valve infective endocarditis. The most frequently performed surgical intervention in patients was the Ross procedure (n=12, 48%). Eight (32%) patients of the center underwent aortic homograft root replacement. Combined surgery was performed in 7 (28%) patients as follows: 3 (12%) patients — interventions on the mitral valve (all patients underwent mitral valve repair due to mitral valve involvement in abscess), 3 (12%) — coronary artery bypass grafting, 1 (4%) — ascending aortic replacement due to dilatation. Five- and ten-year survival after surgical treatment of patients with aortic root abscess was 86,9% and 78,6%, respectively. There was no reintervention and recurrence of infective endocarditis in the long-term period.
Perfect storm: a clinical case of multisite (brain, coronary, renal and spleen) embolism in patient with atrial fibrillation
Authors: Novitsky N. I. , Baglikov A. N. , Soloveva A. E. , Kruchinova S. V. , Kosmacheva E. D. , Villevalde S. V.
Published: September 2024

Nonvalvular atrial fibrillation (AF) is the most common cause of arterial thromboembolism, especially of ischemic stroke. Other than stroke AF-associated embolic events are usually underestimated but at least similarly important. We present a rare case of simultaneous multiple embolism in a 70 years old women with permanent AF.
KÜRESEL FİNANSAL KRİZİN MUHASEBE İHTİYATLILIĞI ÜZERİNE ETKİSİNİN İNCELENMESİ: BORSA İSTANBUL ÖRNEĞİ
Authors: Terzi Serkan , Kocabıyık İsmail
Published: September 2024

Bu araştırmanın amacı, küresel finansal krizin muhasebe ihtiyatlılığı üzerine etkisinin incelenmesidir. Bu doğrultuda 2005-2012 yılları arasında Borsa İstanbul’da işlem gören şirketlerin finansal verileri analiz edilmiştir. Analize dahil edilen şirketlerin finansal verileri, Kamuyu Aydınlatma Platformu ile Thomson Refinitiv Datastream programı kullanılarak temin edilmiştir. Çalışmada 2005-2007 dönemleri kriz öncesi dönemi, 2008-2009 dönemleri kriz dönemi, 2010-2012 dönemleri ise kriz sonrası dönemleri olarak kategorize edilerek analize dahil edilmiştir. Çalışmada muhasebe ihtiyatlılığının ölçümünde piyasa değerinin defter değerine oranı ile C skor kullanılmıştır. Analizde kullanılan değişkenler için birim kök ve çoklu bağlantı testleri yapılmıştır. Krizin ihtiyatlılık üzerine etkisinin tespitinde panel veri analizi ve Driscoll-Kraay dirençli tahmincisi kullanılmıştır. Elde edilen bulgular, küresel finansal krizin muhasebe ihtiyatlılık düzeyi üzerinde etkili olduğunu, kriz döneminde ihtiyatlılık düzeyinin azaldığını, kriz döneminden sonra ise kriz öncesine ve kriz dönemine göre ihtiyatlılığın daha fazla arttığını göstermektedir. Çalışmada finansal kriz dönemi ile muhasebe ihtiyatlılığı üzerinde negatif yönlü bir ilişki, kriz döneminden sonra ise pozitif yönlü bir ilişki tespit edilmiştir.
HİZMET SEKTÖRÜNDE KONTROL KARTLARI KULLANIMI: KENT İÇİ TOPLU TAŞIMA SEKTÖRÜNDE BİR UYGULAMA
Authors: Kuvvetli Umit
Published: September 2024

Üretim sektörünün aksine istatistiksel kalite kontrol kartlarının hizmet sektöründe kullanımı oldukça sınırlıdır. Bu çalışmada, bir kentteki yaşam kalitesini etkileyen en önemli hizmet sektörlerinden olan kent içi toplu taşıma sektöründe farklı kalite kontrol kartlarının nasıl ve ne amaçla kullanılabileceği araştırılmıştır. Bu doğrultuda, örnek bir otobüs hattında 55 güne ait 715 seferdeki otobüs içi yolcu sayısı değişkeni ile 55 güne ait toplam biniş sayısı değişkenlerinin izlenmesinde Shewhart, EWMA ve CUSUM kontrol kartları kullanılmıştır. Elde edilen sonuçlar, kent içi toplu taşıma sektöründe taktiksel planlamalar için Shewhart, operasyonel planlamalar için ise EWMA ve CUSUM kartlarının, kalite izleme ve iyileştirme amaçlı çalışmalarda faydalı olabileceğini göstermektedir.
A COMPREHENSIVE REVIEW OF DISASTER MANAGEMENT MODELS AND APPROACHES BASED ON AMERICAN STUDIES
Authors: Sarı Bektaş
Published: September 2024

This study aimed to comprehensively evaluate the research that has significantly impacted the advancement of disaster management models and approaches since the early 20th century. This review article focuses on scholarly papers indexed in Web of Science and Scopus, which present disaster management models. The selection criteria for these articles were based on their circular models or visual representations of disaster and crisis management from a diverse range of perspectives since 1920. Various disciplines, including public administration, sociology, geography, psychology, and civil defence, have shaped disaster management. Before the 1970s, pioneers in the field, including Prince (1920), Carr (1932), Powell (1954), Chapman (1962), and Stoddard (1968), analysed the impact of disasters on society, and their studies were a significant contribution to the development of disaster management. The circular disaster management model was first introduced by Baird et al. in 1975, focusing on relief-based initiatives. In 1987, Mitroff and fellow researchers delved deeper into the subject, exploring reactive and proactive approaches while integrating the notion of vulnerability. Later models incorporated entitlements such as development, economic progress, risk, hazard, and strategic planning. As time passed, these models grew more extensive and all-encompassing. Nevertheless, disaster management still requires further advancement to tackle crucial challenges like climate change, sustainable development goals, resilience, and the Sendai risk reduction framework. It is recommended that these issues be addressed under the leadership of public administration.
Ethos and expertise in the making of a celebrity (citizen) scientist
Authors: Speicher Nolan
Published: September 2024

For most of the past two centuries, the scientific study of fungi was little more than a small, inconspicuous subfield of plant biology. Today, that is rapidly changing, as mycologists and their objects of study (fungi) are increasingly attracting young scientists and occupying the public sphere in both medicinal and environmental contexts. At the root of mycology’s popular ascendance is Paul Stamets, a self-trained mycologist, author, entrepreneur, and frequent public spokesperson. This essay offers a rhetorical analysis of Stamets’s most influential public appearance—a 2008 TED talk entitled “6 ways mushrooms can save the world”. In particular, I draw on theoretical frameworks in rhetoric and studies of expertise and experience (SEE) to explain how an amateur scientist holding no credentials beyond a bachelor's degree developed an authoritative voice as a thought leader in his field.
DEVELOPMENT OF LEAK DETECTION METHODS FOR USE IN FIELD PIPELINE TRANSPORT
Authors: Romanchuk A.S. , Khabirov S.S. , Vinogradov P.V. , Valiakhmetov R.I. , Gundorova I.G. , Nebogin D.A.
Published: September 2024

Today, most existing leak detection methods are effective only for stationary operating conditions of pipelines. During transient (dynamic) pumping modes, a significant decrease in the sensitivity of the methods occurs, or inoperability of leak detection systems (LDS) based on them is observed.Accordingly, for the operation of the LDS in the presence of transient processes in pipelines, it is necessary to use special approaches that take into account the features and interrelation of the monitored indicators of the dynamically changing pumping regime with each other. One solution to this problem is the use of a dynamic thermal-hydraulic model of the pipeline, which makes it possible to calculate pumping indicators at intermediate and boundary points of the pipeline at each moment in time.The article presents the developed digital model of a pipeline transporting single-phase flows, as a system of equations obtained from the laws of conservation of mass, momentum and energy. The model describes all significant processes and effects during the movement of the pumped flow through a pipeline and allows you to calculate the main characteristics of the flow, including finding the pressure and temperature distributions along the pipeline route.The method for detecting leaks from field pipelines operating under transient (dynamic) conditions is to compare the actual measured flow rate at the end point of the pipeline with the flow rate calculated using a dynamic model of this pipeline, into which the measured pumping indicators at the inlet of a real object are previously transferred. If there are significant deviations between the calculated pumping flow rate at the outlet of the pipeline in the model and the flow rate measured at the pipeline, a leak is concluded.In order to check the performance of the proposed solutions, modeling of leaking pipelines was carried out in specialized software at various flow rates, media viscosities and leak volumes. Based on the data obtained, a conclusion was made about the efficiency of the developed method.Thus, thanks to the proposed approach, it will be possible to promptly detect and eliminate leaks and withdrawals through unauthorized taps on field pipelines operating in unsteady mode, which in turn will significantly reduce operating costs associated with eliminating the consequences of failures.
The Influence of Capacity Building on Small-Scale Agro-Processors in South Africa: Lessons for Agricultural Extension Advisory Services
Authors: Manasoe B , Mmbengwa V , Lekunze J
Published: September 2024

This paper examines capacity building from the perspective of business growth and success in small-scale agro-processing enterprises. Our analytical approach was underpinned by the inability of small-scale agri-enterprises to grow and succeed despite the South African government's support for capacity building through the economic empowerment programme initiative in the past three decades. The study was conducted in five of nine selected South African provinces (Gauteng, Limpopo, North-West, Free State, and Mpumalanga). This study was essential for developing an effective strategy for enhancing agri-business growth and success in South Africa. A concurrent mixed-methods research design was used, and data from 503 small-scale agro-processors was analysed using descriptive and multiple regression analysis techniques. The results revealed that capacity building (β = 0.274, p = 0.000) significantly influences the economic empowerment of small-scale agro-processors. Furthermore, the study showed that mentorship and technical and financial skills are critical types of capacity building that influence the economic empowerment of small-scale agro-processors in South Africa. It is recommended that all government or private stakeholders, including agricultural extension advisory services, invest in capacity-building programmes for small-scale agro-processors to achieve economic empowerment. Economically empowered small-scale agro-processors will significantly contribute to employment creation and better income distribution.
Sanger Tree of Life HMW DNA Extraction: Automated MagAttract for Small Arthropods v1
Authors: Denton Amy , Thomas Abitha , Howard Caroline
Published: September 2024

This protocol describes the automated extraction and SPRI of HMW DNA from small arthropod samples intended for long-read sequencing using the Qiagen MagAttract HMW DNA extraction kit and the Thermo Fisher KingFisher™ Apex. This protocol is primarily effective for the class Arachnida and order Isopoda within Arthropoda covered by the Tree of Life Programme. This protocol has resulted in successful extractions for a number of species including Linyphia triangularis, Anilocra frontalis, Lekanesphaera levii, Cymodoce truncata, Porcellio scaber, Idotea baltica and Ligia oceanica, as well as a reference genome generation for Troglohyphantes excavatus. The output of this protocol is HMW DNA, which depending upon yield and genome size of the species, can be directed towards either HMW DNA Pooling, HMW DNA Fragmentation: Diagenode Megaruptor®3 for LI PacBio or HMW DNA Fragmentation: g-Tube for ULI PacBio. This protocol was primarily adapted from the 'HMW DNA Extraction of Jumping Spiders v.4' protocol; this was developed through R&D by the Meier/Jiggin group for jumping spider tissue, which uses elements of the Qiagen MagAttract protocol and the Lawniczak Lab extraction v.6 for small insects. This protocol also incorporates the pre-shear SPRI element of the 'Sanger Tree of Life HMW DNA Extraction: Automated MagAttract v.2' protocol. Acronyms HMW: high molecular weight SPRI: solid-phase reversible immobilisation LI: low input ULI: ultra-low input
ClickSeq: Random-Primed Protocol with Single Indexing using ClickSeq Kit v1
Authors: Routh Andrew , Jaworski Elizabeth
Published: September 2024

ClickSeq is a simple, fragmentation-free method for the synthesis of Next-Generation Sequencing (NGS) libraries. ClickSeq derives its name by using ‘Click-Chemistry‘ in the place of common ligation enzymes to ‘click-ligate’ nucleic acids to sequencing adaptors – an essential and often problematic step in the synthesis of Next-Generation Sequencing cDNA libraries. The process takes advantage of the chain-terminating properties of 3′-azido-nucleotides, which are included the initial in vitro reverse-transcription reactions uniformly required for RNAseq. The modified nucleotides are stochastically incorporated into the nascent cDNA, yielding cDNA fragments blocked at their 3′ ends with azido groups. The 3′-azido-blocked cDNA fragments are ‘click-ligated’ onto alkyne-functionalized sequencing adaptors, which can subsequently be PCR-amplified to yield a sequencing-ready NGS library. ClickSeq is a highly flexible and modular platform for NGS library synthesis where both RNA and DNA templates can be used as input material. ClickSeq offers many advantages over standard RNA NGS protocols as click-chemistry is utilized to attach on the required sequencing adapter, rather than commonly used enzymatic reactions. Overall, this results in increased efficiency of the protocol, fewer processing steps, and reduced time from RNA to sequencing ready libraries. Additionally, since there are no fragmentation steps typically required in common RNA-seq approaches and because in vitro template switching during RT is limited by the chain terminating azido-nucleotides, ClickSeq offers the benefit of ultra-low artifactual chimera rate, with only 3 chimeric events per million reads.
HOW TO DESIGN PODCAST FOR LEARNING WITH THE RAPID PROTOTYPE MODEL
Authors: Fadlillah Ahmad Fajar , Dewi Laksmi , Hernawan Asep Herry
Published: September 2024

A podcast is a digital audio recording disseminated over the internet that can be transmitted, played, and downloaded directly to consumer media devices, including portable music players, computers, laptops, and smartphones. It can be categorized as an m-learning strategy for teaching and learning. It allows students to learn independently, easy to use, dynamic content meeting to listeners’ needs, and portable. The categories of using podcasts for learning are as sub-constitutional, supplemental, and integrated. Several things need to be considered in designing a podcast for learning covering its course’ objectives, students’ character, goal, type, writer, correlation to other teaching materials, a style used, duration, media, technology and material, sound used, the image included, and music. In designing a good podcast for learning, it is necessary to apply a systematic learning system's systematic procedure. This article discusses how to design podcasts for learning with The Rapid Prototype Model. This model is an instructional design method used to design and develop models with the stages of needs analysis, content analysis, determining objectives, constructing prototypes, utilizing prototypes, and installing and maintaining the system.
Damage to the organ of hearing and upper respiratory tract in vasculitis associated with antineutrophil cytoplasmic antibodies
Authors: Klimenko A. A. , Loginova T. K. , Sahakyan Yu. M. , Petrikova V. I. , Andriyashkina D. Yu.
Published: September 2024

Antineutrophil cytoplasmic antibodies associated vasculitis (ANCA-AV) is a systemic necrotizing granulomatous vasculitis affecting mainly small-caliber vessels. ANCA-AV occupy a special place among systemic vasculitis, which is characterized by a highly active life-threatening course of the disease, requiring rapid differential diagnosis and aggressive immunosuppressive therapy. The ANCA-AV group consists of 3 nosologies: granulomatosis with polyangiitis, eosinophilic granulomatosis with polyangiitis and microscopic polyangiitis. The “calling card” of ANCA-AV is the lesion of the upper respiratory tract, especially the ENT organs (70–100 % of patients). The nasal cavity and paranasal sinuses are the most common areas of lesion in the head and neck (85–100 %), whereas ear damage occurs in about 35% (range, 19–61 %) of cases. Lesion of the ENT organs is typical for the debut of ANCA-AV, which makes early diagnosis difficult, since diseases of the upper respiratory tract are extremely common in all age groups. Diagnosis verification occurs mainly at the stage of generalized involvement of many organs and systems, causing severe course with the development of pulmonary-cardiac and renal insufficiency, which lead to the death of the patient. The main ENT manifestations of ANCA-AV can be grouped into several groups: sinonasal, otological, tracheobronchial, oral cavity lesions and others. Pseudotumors are often found in ANCA-AV. They are characterized by the appearance of parapharyngeal, parotid, submandibular, paratracheal volumetric formations. As a rule, the appearance of tumor-like formations is observed at an early stage of the disease and is associated with the presence of antibodies to proteinase 3, systemic manifestations of vasculitis. Pseudotumor in the ENT region may be accompanied by secondary neuropathies of cranial nerves, destruction of bone tissue, which requires histological verification of the disease.
The Hydrological Impact of Historical and Modern Earthquakes in Central-Southern Italy: Data Analysis and Seismotectonic Insights
Authors: Cucci Luigi , Tertulliani Andrea , Castellano Corrado
Published: September 2024

We present the results of research conducted on the hydrological effects induced by historical and modern earthquakes in the central-southern Apennines of Italy. We investigated thirty-nine seismic events of magnitude between M 4.1 and 7.1 that occurred between 1688 and 2020. We collected 526 observations of coseismic and postseismic hydrological effects such as increase or decrease in streamflow, variations in the water levels in wells, formation and/or disappearance of springs and changes in their discharge, and changes in the chemical and physical characteristics of waters. More than half of the observations were new data unpublished to date in the scientific literature. We find that the ease of finding data of interest is strongly influenced by the historical period in which the seismic event occurred. We summarize the methodology of data retrieval and its classification and present examples and maps of coseismic hydrological changes associated with individual seismic events. Most of our novel data derive from seismic postcards, macroseismic questionnaires, and hydrographic annals. However, a nonnegligible set of data comes from a careful rereading of sources—both historical and modern—that were at first considered fruitless. The majority of data concerns an excess flow in streams and springs, and physical–chemical variations such as turbidity, an increase in temperature, and gas emission. We also find that the maximum distance to which seismically induced streamflow responses have been reported can be related to the earthquake magnitude and use this distance to derive an alternative magnitude for some of the strongest earthquakes of our dataset. Finally, we show a potential application of this type of research because the distribution of coseismic hydrological changes can provide constraints in discriminating between the causative faults of strong historical seismic events for which the instrumental data are scarce or not available.
“It’s Not Easy Being Around That Kind of Sickness”: Intellectual Disability and the COVID-19 Pandemic
Authors: Monteleone Rebecca
Published: September 2024

The COVID-19 pandemic has disproportionately affected people with intellectual and developmental disabilities (I/DD), and yet their perspectives and experiences have not been incorporated into the vast majority of research, public health plans, or social service provision. This article presents the pandemic experiences of twelve adults with I/DD living in the United States in late spring 2020. Findings include informants’ uncertainty about the virus and its impacts, difficulties navigating changes to housing, employment, and schedules, increased feelings of personal responsibility, and exacerbated tensions in professional and personal relationships. I conclude with recommendations for research, policy, and practice that privilege the lived experiences of people with I/DD during times of crisis.
Management of cubitus varus deformity by three-dimensional osteotomy: analysis of outcome
Authors: Khan M. Zahidul Haq , Das Krishna Priya , Islam M. Ashraful , Sarker M. Hafijur Rahman , Sidny Nabil Zunayed
Published: September 2024

Background: Cubitus varus deformity, commonly resulting from malunited supracondylar fractures of the humerus, is prevalent in pediatric and adolescent populations. Traditional treatment methods often fall short in addressing the complex three-dimensional nature of this deformity. This study aims to evaluate the efficacy and outcomes of three-dimensional osteotomy in correcting cubitus varus deformity.
Methods: This prospective interventional study was conducted at the Department of Orthopaedic Surgery, BSMMU, Shahbag, Dhaka, from March 2016 to September 2018. A total of 40 patients aged 8 to 20 years with cubitus varus deformity were enrolled. Participants underwent three-dimensional osteotomy, and outcomes were assessed using the Mayo Elbow Performance Score (MEPS) and functional recovery parameters.
Results: The majority of patients (75%) achieved bone union within 8-10 weeks post-osteotomy. The MEPS results were promising, with 40% of patients scoring 'Excellent' and 45% scoring 'Good'. Functional outcomes were predominantly positive, with 95% of patients reporting satisfactory results. The complication rate was low, with 80% of patients experiencing no postoperative complications.
Conclusions: Three-dimensional osteotomy is an effective and reliable surgical intervention for treating cubitus varus deformity, offering high rates of patient satisfaction, minimal complications, and improved functional outcomes. This technique presents a promising option for orthopedic surgeons in managing this complex deformity.
Needs Analysis in Developing Digital Flashcards for Indonesian Language Learning in Elementary School
Authors: Hanisah Hanisah , Sutomo Moh , Saihan Saihan
Published: September 2024

This study aims to analyze the needs in developing digital flashcards in Indonesian language learning to increase reading interest. The analysis was conducted through a qualitative case study with the research subjects selected by purposive sampling, including the principal, curriculum deputy, grade 1 teacher, and 30 students. Data collection methods involved observation, interviews, documentation, and learner questionnaires, with analysis using triangulation techniques. The results showed a lack of utilization of digital learning media, especially digital flashcards, at MI Daru Falah Wirowongso Jember, especially in grade 1, to support learners' interest in reading. In response to these findings, researchers analyzed the needs that can be implemented in the development of digital media, especially digital flashcards. The implications of this research are expected to provide a more comprehensive view of the needs of Indonesian language learning in the digital era, as well as providing a foundation for further development in increasing students' interest in reading through relevant and effective learning media.
Antimicrobial effects of ropivacaine, levobupivacaine and bupivacaine at different temperatures
Authors: Duruk Erkent Fatmanur , Günaydın Berrin , Erdoğan Merve , Kalkancı Ayşe
Published: September 2024

Aim: Various prior studies have shown a possible antimicrobial activity of different local anesthetic (LA) drugs. The aim of this study was to assess the antimicrobial (antibacterial or antifungal) activity of commonly used commercially available LA drugs used in regional anesthesia practice such as; ropivacaine, levobupivacaine and bupivacaine on S.aureus ATCC 6538, S. epidermidis, E.coli and Candida albicans at different temperatures.
Material and Methods: Possible antimicrobial effects of ropivacaine (1% and 0.125%), levobupivacaine (0.75% and 0.125%) and bupivacaine (0.5% and 0.125%) on S.aureus ATCC 6538, S.epidermidis, E.coli and C.albicans ATCC 10231, which were isolated from patients in the microbiology laboratory were investigated at 240C and 37C.
Results: All three LA drugs showed antifungal activity at 37°C and 24°C in 3rd and 12th hours. Levobupivacaine’s (0.75%) antibacterial effect was observed at the 12th hour. Ropivacaine (1%) had relatively more antibacterial effect at the 3rd and 12th hour at 37°C rather than 24°C whereas bupivacaine had less.
Conclusion: Potential clinical implications of antibacterial or antifungal effects of local anesthetics might be promising.
Angular in .NET kot konkurenca namiznim aplikacijam
Authors: Prtenjak Matjaž
Published: September 2024

V kolikor ste spremljali moje prispevke v prejšnjih letih, boste presenečeni, saj bo ta prispevek zadeve obrnil na glavo. V kolikor pa ste z mano prvič, pa tudi ne skrbite, saj je prispevek povsem zaključena celota in neodvisen od prejšnjih prispevkov. V prispevkih prejšnjih let smo se spraševali, kako (starejše) razvijalce, ki so navajeni namiznih aplikacij, naučiti dela v spletnih aplikacijah, danes pa se sprašujemo, kako spletno aplikacijo napisati tako, da jo lahko damo na namizje. Vprašanje, ki se smiselno pojavlja je: »Zakaj bi to sploh počeli?«. Zakaj bi želeli spletno aplikacijo imeti kot namizno aplikacijo oz. jo gostiti sami? Odgovori so lahko različni, najpomembnejši pa je: zaupanje. Obstajajo uporabniki – tudi (ali predvsem) v poslovnem svetu, ki želijo imeti aplikacije pri sebi. Če želimo spletno aplikacijo prenesti k uporabniku, je zadeva dokaj preprosta. Uporabnik pri sebi postavi spletni strežnik, ki je dosegljiv samo v njegovem poslovnem okolju in aplikacija se prenese na ta strežnik in s tem je zadeva bolj ali manj zaključena. Kaj pa, če ne želimo postavljati spletnega strežnika? Ali bi ne bilo bolje, če lahko uporabnik naloži aplikacijo s spleta, jo požene in slednja teče? Ali pa jo celo kopira v mapo, požene in zadeva deluje?
Implementing Gender Motivation Theory in Intimate Partner Violence
Authors: Winstok Zeev , Sowan Wafa , Bailey Benjamin , Smadar-Dror Ronit , Weinberg Michael , Melhausen-Hasson David , Berkowitz Ruth , Crombie Zeev
Published: September 2024

The aim of this article is to present and examine the principles of gender motivation theory against a backdrop of research findings accumulated over time. This theory is founded on two general, established, major theories: sexual selection theory and social role theory. Gender motivation theory focuses on the elementary primal motivations of men and women in social situations and contexts. This theory provides a theoretical foundation for a gendered understanding of intimate relationships among normative and clinical populations. Gender motivation theory was developed as a response to the existing discrepancies between previously developed theories whose principles continue to be used to understand and intervene with intimate partner violence and as a response to empirical data accumulated over the years.
Analysis of Factors of the Use of Food Additives in the Elementary School
Authors: Asyfiradayati Rezania , Astuti Dwi , Ambarwati Ambarwati , Firmansyah Firmansyah , Kumala Junisa , Widyasari Rita Aprilia , Wati Wiwik Novia , Nindyasari Jenita Berlian , Mohd Yatim Siti Rohana
Published: September 2024

Background: Merchants sell a variety of food for schoolchildren. In an attempt to make the food they offer more enticing and long-lasting, dealers frequently add food additives, sometimes prohibited food additives which is against the law. Predisposing conditions affect the addition of additives to snacks.
Objectives: The study aimed to determine the factors that influence the addition of food ingredients not allowed by snack vendors in snacks sold around elementary schools
Methods: This study used a survey approach with a cross-sectional design. The 99 traders that made up the study's sample were chosen randomly. The use of food additives was the dependent variable and the independent variables were gender, education, knowledge, age, and length of selling. Test kits were used in laboratories to analyze snack samples sold by traders in order to identify food additives (formalin, borax, Rhodamine B, and Yellow Methanol). Multivariate, bivariate, and univariate analysis were used in the research process. The multiple logistic regression with 95% Confident Interval and chi-square statistical tests were employed in this investigation.
Results: The number of snacks checked by test-kit with the result was 21.2% of snacks containing prohibited food additives with a good level of knowledge on the sword as much as 52.5%. The results of the chi-square test statistics for knowledge (p=0.001), age (p=0.010), length of sale (p=0.022) was related to the use of prohibited food additives. The results of multivariate analysis showed that knowledge was the most influential factor in the use of food additives.
Conclusions: Traders' knowledge about the use of food additives was the main factor, besides that relate factors were age and length of selling.
Lifestyle and well-being of university students in Japan: a cross-sectional study
Authors: Fukuie Takemune , Inoue Koshiro , Yamaguchi Akihiko
Published: September 2024

Mental health, academic motivation, and exercise participation remain critical issues for well-being of university students. This study aimed to explore lifestyle elements that influence mental health, academic motivation, and participation of three types of exercise among university students. This cross-sectional study was conducted between October 2022 and December 2022. A total of 240 first-year students (mean age: 18.70 ± 0.53 years; age range: 18–21; 166 female) participated in the study. Participants measured and recorded their lifestyle for a week using accelerometer and an Excel format. Measurements included daily step counts; dietary habits; sleep habits; exercise participation by type, such as aerobic exercise (AE), resistance exercise (RE), and flexibility exercise (FE); screen time; eye fatigue; club activities; part-time job time; depression; and academic motivation. Path analysis revealed that longer FE and higher subjective sleep quality predicted lower depression (β = −0.11, P < 0.05; β =−0.23, P < 0.001). Screen time commonly predicted depression (β = 0.11, P < 0.05) and academic motivation (β = −0.15, P < 0.05). Frequency of exercise less than 5 min commonly predicted total time of AE (β = 0.20, P < 0.01), RE (β = 0.23, P < 0.001), and FE (β = 0.21, P < 0.001). Decreasing screen time could be a common key factor for good mental health and academic motivation. Increasing short-term frequent exercise could be an implementable strategy for increasing participation in all three types of exercise.
Quantifying Genetic Parameters for Blackleg Resistance in Rapeseed: A Comparative Study
Authors: Bocianowski Jan , Starosta Ewa , Jamruszka Tomasz , Szwarc Justyna , Jędryczka Małgorzata , Grynia Magdalena , Niemann Janetta
Published: September 2024

Selection is a fundamental part of the plant breeding process, enabling the identification and development of varieties with desirable traits. Thanks to advances in genetics and biotechnology, the selection process has become more precise and efficient, resulting in faster breeding progress and better adaptation of crops to environmental challenges. Genetic parameters related to gene additivity and epistasis play a key role and can influence decisions on the suitability of breeding material. In this study, 188 rapeseed doubled haploid lines were assessed in field conditions for resistance to Leptosphaeria spp. Through next-generation sequencing, a total of 133,764 molecular markers (96,121 SilicoDArT and 37,643 SNP) were obtained. The similarity of the DH lines at the phenotypic and genetic levels was calculated. The results indicate that the similarity at the phenotypic level was markedly different than the similarity at the genetic level. Genetic parameters related to additive gene action effects and epistasis (double and triple) were calculated using two methods: based on phenotypic observations only and using molecular marker observations. All evaluated genetic parameters (additive, additive-additive and additive-additive-additive) were statistically significant for both estimation methods. The parameters associated with the interaction (double and triple) had opposite signs depending on the estimation method.
Reviving the Practices of Transhumance in a Forgotten Settlement in Mainland Greece
Authors: Tzortzi Julia Nerantzia , Theodoridou Sofia , Koukosoula Styliani
Published: September 2024

The object of this research project is the investigation of the forgotten landscape of transhumance in mainland Greece, focusing on areas abandoned by modern society and their historical passage. The objective is to revive these lands by restoring their cultural heritage and creating a sustainable community that balances the needs of people, livestock, and the environment. The investigation employs a dual approach: studying transhumance as a cultural and natural practice and analyzing anonymous architecture to preserve collective memory. This involves extensive historical research and a simultaneous analysis of spatial, social, symbolic, and architectural elements. The study identifies convergence points between cultural practices and architectural heritage, applying these insights to modern redevelopment scenarios. Findings reveal a significant interplay between transhumance practices and the region’s anonymous architecture. Key characteristics of the landscape and its spatial identity are documented, providing insights into effective preservation and redevelopment strategies. Specific case studies validate these strategies, demonstrating their relevance to current and future efforts. The study concludes that understanding the historical context and spatial identity of transhumance landscapes is crucial for sustainable redevelopment. By preserving cultural practices and architectural heritage, this project offers a framework for revitalizing these forgotten landscapes, ensuring balanced coexistence of people, livestock, and the environment.
Unveiling the Metabolic Trajectory of Pig Feces across Different Ages and Senescence
Authors: Qiao Chuanmin , Liu ChengZhong , Ding Ruipei , Wang Shumei , He Maozhang
Published: September 2024

Porcine metabolomics research has been extensively conducted, primarily focusing on conventional cohorts or animal models. However, the composition and functions of fecal metabolites in pigs at various ages, particularly in the elderly, remain poorly understood. In the present study, an untargeted metabolomics approach was employed to analyze the fecal metabolomes of pigs at three distinct age stages, with the aim of elucidating age-associated changes in metabolite composition and functionality under standardized rearing conditions. Through the untargeted metabolomic analysis of fecal samples from young (one year), middle-aged (four years), and elderly (eight years) pig cohorts, a variety of age-related metabolites were identified. For example, L-methionine sulfoxide was observed to increase with age, while cytidine-5-monophosphate exhibited a concomitant gradual decrease during the aging process. These metabolites were found to undergo alterations across multiple biological pathways, including energy metabolism, pyrimidine metabolism, lipid metabolism, and amino acid metabolism. Furthermore, the age-dependent metabolic changes were associated with known senescence biomarkers, offering new insights into the mechanistic understanding of aging in pigs.