bluuebunny/crossref_metadata_2025 huggingface dataset:
Determination of the metabolic profile of Solidago canadensis using UFLC-PDA-ESI-TOF
Authors: Kelly Andressa Maia , Oliveira Temistocles Barroso de , Valverde Simone Sacramento
Published: July 2020

Abstract Species in the Solidago genus are used worldwide due to the therapeutic activities of their flavonoids and terpenoids. Its anti-inflammatory, antirheumatic, analgesic, diuretic, aquaretic, wound-healing properties as well as its ability to relieve burn and insect bites allow use in a variety of situations. This study was carried out to determine the metabolic profile of Solidago canadensis inflorescences (SCAI) to identify the species commercialized in Rio de Janeiro, RJ, Brazil, and evaluate the medicinal potential compared to S. chilensis and SCAI, which is used in North America and Europe. The UFLC-PDA-ESI-TOF revealed the metabolic profile of SCAI, finding the pseudo-molecular ions and characteristic fragments, mainly flavonols (10) such as quercetin, kaempferol, isorhamnetin, and its glycosides, as well as chlorogenic acid (CA). Eleven substances were identified, confirming the compatibility of the metabolic profile presented in varieties canadensis and scabra of european S. canadensis. The both contain the same flavonoid aglycones, and their glycosides are important chemical and biological markers for extracts and products based on species of the genus Solidago. UFLC-PDA-ESI-TOF characterized the extracts, which can help with quality control of raw plant materials and commercialized phytotherapeutics as well as for development of new products and phytomedicines.
Phytochemical analysis and hypotensive activity of Ipomoea pes-caprae on blood pressure of normotensive rats
Authors: Gonçalves Fernanda Manhães Braga , Ramos Amaro Chaves , Mathias Marcelo da Silva , Sales Queitilane de Souza , Ramos Carolina Chaves , Antunes Fernanda , Oliveira Rodrigo Rodrigues de
Published: July 2020

Abstract Ipomoea pes-caprae (Convolvulaceae), popularly known as “salsa-da-praia”, is used in folk medicine for the treatment of several diseases, including hypertension. The aim of this research was to evaluate hypotensive activity attributed to this species and identify the bioactive compounds responsible for this effect. Hydroalcoholic extract of aerial parts of Ipomoea pes-caprae (PIEA) was fractionated by column chromatography with Amberlite XAD-2, thus achieving a methanolic fraction (PIEA-M). The chemical profile investigation of PIEA-M was conducted by Ultra Performance Liquid Chromatography coupled to Mass Spectrometry (UPLC-MS) and compound isolation through High Performance Countercurrent Chromatography (HPCCC). Hemodynamic evaluations of PIEA, PIEA-M and isolated compounds were carried out on normotensive rats. The locomotor activity of PIEA and PIEA-M were performed by Rota Rod test using Swiss mice. UPLC-MS analysis of PIEA-M led to the identification of 11 compounds corresponding to seven phenolic acids and four flavonoids. By means of HPCCC, quercetin 6”-O-acetyl-3-O- glucoside (1), a mixture of quercetin-3-O-galactoside and quercetin-3-O- glucoside (2) and quercetin 3-O-glucoside (3) were isolated. PIEA, PIEA-M and the obtained compounds (1 and 2) significantly reduced blood pressure. Also, PIEA and PIEA-M caused significant impairment on mice locomotor activity. These results indicate the potential of Ipomoea pes-caprae as a source of hypotensive agents suggesting that phenolic compounds present in the species are responsible for its hypotensive activity.
Phytochemical screening and biological assays of ethanolic leaf extract of Senna rugosa
Authors: Cunha Letícia Figueiredo , Costa Camila Marques , Barroso Poliana Ribeiro , Kato Kelly Cristina , Oliveira Fabrício de , Mendonça Filho Carlos Victor , Grael Cristiane Fernanda Fuzer , Gregório Luiz Elídio , Campos Fernanda Fraga , Oliveira Patrícia Machado de , Oliveira Danilo Bretas de , Ruela Fernando Armini , Martins Helen Rodrigues
Published: July 2020

Abstract Senna rugosa (Fabaceae) is a common specie of the Brazilian territory, especially in the Cerrado biome. It is widely used in the popular medicine although not yet adequately investigated as to its phytoconstituents and pharmacological activities. In this study, the preliminary phytochemical analysis of ethanolic leaf extract of S. rugosa was performed and its cytotoxicity, antitumoral and antimicrobial activities (antibacterial, antifungal, anti-Trypanosoma and anti-Leishmania) were evaluated. The crude extract was analyzed in HPLC-DAD and fractions were also characterized using GC-MS and ESI-MS techniques. Results indicate phenolic compounds majority presence, including flavonol, anthraquinone and anthrones derivatives. Relative antimicrobial activities were detected against Staphylococcus aureus, Pseudomonas aeruginosa, Candida famata, Candida krusei and Candida tropicalis. As well as, a weak anti-trypanosomatids activity against M2269 strain and BH46 strain of Leishmania sp. A relative antitumoral activity was also identified but in counterpoint were also observed a toxicity in fibroblast cells (L929). Phytochemically, results provide evidence that phenolic compounds in S. rugosa leaves might be the responsible for its antimicrobial activity and cell toxicity inferred in our research.
Duroia saccifera: in vitro germination, friable calli and identification of β-sitosterol and stigmasterol from the active extract against Mycobacterium tuberculosis
Authors: Lozano Stefhania Alzate , Sousa Aline Bastos Brilhante de , Souza Julio Cezar de , Silva David Ribeiro da , Salazar Marcos Gabriel Maciel , Halicki Priscila Cristina Bartolomeu , Ramos Daniela Fernandes , Silva Pedro Eduardo Almeida da , Nunez Cecilia Veronica
Published: July 2020

Abstract Duroia saccifera (Rubiaceae) occurs in the Amazon rainforest and their extracts showed antibacterial properties. To obtain greater quantities of active substances, leaf segments from in vitro D. saccifera seedlings were used as explants for calli induction; calli were multiplied via multiple subcultures, dried and extracted with hexane followed by ethyl acetate (EtOAc) and methanol (MeOH). As D. macrophylla had been reported to produce antimycobacterial substances, we assayed calli extracts against Mycobacterium tuberculosis (H37Rv strain). Calli EtOAc extract was active, with a minimal inhibitory concentration (MIC) of ≤ 25 mg mL-1, IC90of 19.5 mg mL-1 and minimal bactericidal concentration (MBC) of 200 mg mL-1. EtOAc extract was analyzed by Thin Layer Chromatography (TLC) and Nuclear Magnetic Resonance (NMR) to determine its chemical profile, and was found to be rich in terpenes. Chromatographic fractionation of the EtOAc extract yielded a mixture of two sterols, β-sitosterol and stigmasterol (in proportion of 2:1), which were identified by 1H and 13C NMR analysis. As far as we know, this is the first report of Duroia saccifera in vitro cell culture, antituberculosis activity of calli extract and β-sitosterol and stigmasterol isolation from in vitro plant cell culture.
Can natural products improve skin photoprotection?
Authors: Chiari-Andréo Bruna Galdorfini , Almeida Fernanda Borges de , Yamasaki Paulo Renato , Santos Jean Leandro dos , Corrêa Marcos Antonio , Chin Chung Man , Isaac Vera Lucia Borges
Published: July 2020

Abstract Due to increased UV radiation on the Earth’s surface, caused by depletion of the stratospheric ozone, people have become more susceptible to different types of skin damage, such as erythema, sunburns, and cancer; this is especially of concern in tropical countries. Thus, efforts to improve awareness as well as the use of sunscreen are increasing worldwide. However, synthetic UV filters have been associated with deleterious effects such as photosensitization. Natural products have been used by ancient cultures for several purposes, including protecting the skin from the sun. However, there is still doubt today whether photoprotection is a real phenomenom or whether it is simply tanning of the skin. Plants have self-protective mechanisms and produce secondary metabolites that can protect themselves from UV radiation. Yet, can phytochemical compounds protect human skin? This review discusses the paradoxical effect of chemical UV filters and the influence of phytochemicals in in vitro and in vivo tests of photoprotection.
Ethnopharmacology: a laboratory science?
Authors: Rodrigues Eliana , Oliveira Danilo Ribeiro de
Published: July 2020

Abstract In 1962, Richard Evans Schultes defined ethnobotany as “the study of the relationships which exist between people of the primitive society and their plant environment”. Ethnopharmacology, considered a sub-discipline of ethnobotany, has been conceptualized in different ways over time. Since the 80’s, implicit in these different concepts was the need for the validation of traditional/popular knowledge through pharmacological and phytochemical studies. According to these ideas, plants or animals identified during fieldwork should be investigated by these sciences in order to prove or disprove their “empirical” use, only resulting in an ethnopharmacological study if they passed through the methodologies of “academic laboratory science”. The historical trajectory of these concepts leads us to think that ethnopharmacology is a science only if tested and proven, without considering or recognizing the knowledge of other cultures as a science in itself. We present here some examples from traditional medicine hoping to bring a conceptual, holistic, practical and ethical reflection on the theme.
Acesso, acessibilidade e demanda na estratégia saúde da família
Authors: Chávez Giannina Marcela , Viegas Selma Maria da Fonseca , Roquini Gabriel Rios , Santos Thiago Rocha
Published: July 2020

RESUMO Objetivo compreender demanda, acesso e acessibilidade perante as necessidades de saúde, sob a ótica de profissionais e usuários da Estratégia Saúde da Família (ESF). Método utilizou-se a Teoria Fundamentada nos Dados, ancorada no Interacionismo Simbólico, com 34 participantes, usuários e profissionais da ESF de município de grande porte. Resultados as demandas cotidianas na ESF e as limitações do acesso evidenciam as dificuldades enfrentadas pelas equipes pela baixa cobertura populacional, elevado número de pessoas cadastradas, baixa resolutividade, falta de profissionais, ineficácia da gestão e escassez de ações programadas. As concepções de acesso, acessibilidade e resolutividade são contextualizadas no acolhimento e humanização, na precisão de ampliar a cobertura populacional e o acesso, além de os usuários e profissionais expressarem seus sentimentos de frustração, angústia e insatisfação perante a baixa resolutividade e insuficiência de recursos. Conclusões e implicações para prática a ESF ainda trabalha a lógica da atenção curativa, cujas atividades são realizadas dentro do consultório, com recursos insuficientes, elevada demanda reprimida e muitos desafios. Apresenta subsídios para que os profissionais de saúde, usuários e gestores busquem, de forma colaborativa, estratégias de enfrentamento da elevada demanda espontânea e dificuldades de acesso.
Estudos sobre a imagem das enfermeiras: cinco décadas entre a imagética e suas repercussões
Authors: Silva Gilberto Tadeu Reis da , Almeida Deybson Borba de , Oliveira Núbia Lino de , Laitano Aline Di Carla , Santos Victor Porfírio Ferreira Almeida , Queirós Paulo Joaquim Pina
Published: July 2020

RESUMO Objetivo Analisar a imagem da enfermeira na imprensa escrita nas décadas de 1930 a 1950 e suas repercussões nas décadas de 1970 a 1980. Método Estudo histórico-documental com abordagem qualitativa, que utilizou como fontes de dados às reportagens publicadas no Jornal baiano A Tarde nas décadas de 1930 a 1980, marcadas por importantes acontecimentos históricos nos cenários nacional e internacional, discussões sobre transformação da imagem e reconstrução da identidade profissional da enfermeira. Resultados Foram identificadas três representações centrais da enfermeira na impressa jornalística: a imagética religiosa e militar da profissão e as repercussões das imagens das enfermeiras como produto/produtoras de outras imagéticas que se escreveram no tempo histórico e que serão produtos de continuidades, rupturas e descontinuidades. Conclusões e implicações para a prática As imagens da enfermeira e suas repercussões são cocriações determinadas no campo social político e econômico que atravessa os tempos e a história estando relacionada aos interesses governamentais e de mercado.
MATISSE E A RELIGIÃO DA ARTE
Authors: Oliveira Paola Lins de
Published: July 2020

Ao se aproximar dos oitenta anos de idade, o artista plástico Henri Matisse embarca com um frade dominicano no projeto de construção de uma capela na região francesa dos Alpes Marítimos. A empreitada gera resistências entre diversos artistas e religiosos, preocupados respectivamente com a contaminação da arte de vanguarda pelo conservadorismo católico e com a profanação modernista da arte sacra. Neste artigo, analiso a construção da Capela do Rosário (1947-1951) como caso-chave para explorar os efeitos do consórcio entre arte e religião promovido por Matisse em dois planos simultâneos e complementares. No primeiro, investigo como a composição entre os vocabulários e práticas religiosas e artísticas potencializa a construção da obra de Matisse, gerando repercussões na própria vida do artista. No segundo, apuro como essa associação produz um tensionamento do princípio moderno e secular de separação entre as esferas da arte e da religião, iluminando os termos dessa separação. O percurso realizado em pesquisa de campo na França e análise de diferentes fontes documentais revela que a religião (seja ela o catolicismo, um espiritualismo difuso ou outras manifestações sagradas) adquire o estatuto de procedimento articulador através do qual o artista constrói sua obra e através dela a si mesmo.
Specters of Colonialidade: A Forum on Jacques Derrida’s Specters of Marx after 25 Years, Part V
Authors: Rodrigues Carla , Haddock-Lobo Rafael , Moraes Marcelo José Derzi
Published: July 2020

Abstract Jacques Derrida delivered the basis of The Specters of Marx: The State of the Debt, the Work of Mourning, & the New International as a plenary address at the conference ‘Whither Marxism?’ hosted by the University of California, Riverside, in 1993. The longer book version was published in French the same year and appeared in English and Portuguese the following year. In the decade after the publication of Specters, Derrida’s analyses provoked a large critical literature and invited both consternation and celebration by figures such as Antonio Negri, Wendy Brown and Frederic Jameson. This forum seeks to stimulate new reflections on Derrida, deconstruction and Specters of Marx by considering how the futures past announced by the book have fared after an eventful quarter century. In this fifth group of contributions, three philosophers explore the specters of colonialidade, the specifically Brazilian legacies of Portuguese and European coloniality. Carla Rodrigues opens the dialogue by exploring the haunting and melancholy provoked by colonial forms of violence and shows how confronting Brazilian necropolitics sustains the Derridean legacy; Rafael Haddock-Lobo offers a meditation on the difficulties of being before the law and standing before specters as a means of being justly haunted by the others of European philosophy in Brazil; finally, Marcelo Moraes continues the theme of Europe as a specter-producing machine and invokes specifically the presences of indigenous and Afro-Brazilian political resistances with the aim of deconstructing coloniality.
Febre a bordo: migrantes, epidemias, quarentenas
Authors: Bastos Cristiana
Published: July 2020

Resumo Neste artigo faço uma retrospetiva dos estudos sobre epidemias a que me dediquei enquanto antropóloga, dando destaque a um fenómeno que interseta os interesses da antropologia da biossegurança e da história das plantações de açúcar e migrações laborais: os surtos epidémicos a bordo dos barcos de migrantes em finais do século XIX. Baseada num relato de mais de 50 mortes infantis por sarampo numa viagem de emigrantes da Madeira para o Hawaii em 1884, e constatando que existiu uma sequência de pelo menos três mortandades equivalentes no espaço de dois anos, discuto questões mais amplas de saúde, desigualdade, tráfico, corpo, género, família, não sem dar atenção à materialidade da vida dos navios que se foram reconfigurando no transporte de força do trabalho escravizada, vinculada e contratada.
Tanatopolítica e biossegurança: dois regimes de governo da vida para a leishmaniose visceral canina no Brasil
Authors: Lewgoy Bernardo , Mastrangelo Andrea , Beck Luiza
Published: July 2020

Resumo Apesar de ter sua legitimidade contestada nas últimas décadas por defensores de animais, juristas e veterinários que defendem o direito à vida e ao tratamento, assim como por pesquisadores da área da saúde que duvidam de sua eficácia, a “eutanásia profilática” massiva de cães testados como soropositivos para leishmaniose visceral mantém-se firme como política sanitária no Brasil. A partir da análise de documentos oficiais, revisão da literatura, comentários sobre processos judiciais colhidos na imprensa e da etnografia dos impactos do surto de leishmaniose visceral em Porto Alegre, este artigo visa compreender o que está em jogo nessa controvérsia, considerando seus aspectos discursivos na construção de moralidades e práticas biopolíticas. Sugere-se a existência de dois regimes de governo da vida na gestão dos reservatórios caninos da leishmaniose visceral: um tanatopolítico, ligado ao poder público; o outro, um dispositivo emergente de biossegurança, ligado ao mercado farmacêutico e acessível apenas para tratamento privado.
PANORAMA DA COVID-19 NO NORDESTE BRASILEIRO: ANÁLISES E PREVISÕES VIA MODELOS DE CRESCIMENTO
Authors: Vasconcelos Giovani L. , Brum Arthur A. , Duarte-Filho Gerson C. , Ospina Raydonal , Almeida Francisco A. G. , Macêdo Antônio M. S.
Published: July 2020

A pandemia da Covid-19, causada pelo novo coronavírus (SARS-CoV-2), é uma das maiores crises de saúde pública que o mundo já enfrentou. Nesse contexto, é importante ter modelos eficazes para descrever os diferentes estágios da evolução da epidemia, a fim de orientar as autoridades competentes na adoção de políticas públicas para o enfrentamento e controle da pandemia. No presente trabalho, nós propomos um novo método de análise de curvas epidêmicas com base na seleção criteriosa de modelos de crescimento, tomando como exemplo as curvas acumuladas de óbitos atribuídos à Covid-19 para os estados da região Nordeste do Brasil. A depender do caso, foram utilizados o modelo q-exponencial, o modelo de Richards ou o modelo generalizado de Richards para fazer o ajuste numérico das respectivas curvas empíricas. Verificou-se que os modelos utilizados descrevem muito bem as curvas empíricas de todos os estados do Nordeste, permitindo assim diagnosticar mais precisamente o estágio da epidemia em cada um dos estados. Dentre eles, apenas o estado da Paraíba ainda encontra-se na fase inicial de crescimento, quando a curva epidêmica ainda não apresenta um ponto de inflexão, sendo nesse caso melhor descrita pelo modelo q-exponencial. Os demais estados foram mais bem descritos ou pelo modelo de Richards ou por sua versão generalizada. O modelo de Richards, em particular, foi capaz de identificar com razoável confiabilidade o surgimento do ponto de inflexão para os estados que só recentemente alcançaram esse estágio da epidemia, como foi o caso do Piauí, Rio Grande do Norte e Sergipe. Esse modelo também é capaz de prever quando a inflexão está prestes a acontecer, como é o caso da Bahia. O modelo generalizado de Richards, por sua vez, mostrou-se mais apropriado para descrever curvas epidêmicas de estados que estão em uma fase mais desenvolvida da epidemia, como Ceará e Pernambuco, quando as curvas epidêmicas já apresentam uma tendência mais consolidada de saturação em direção ao platô.
Improving Energy Harvesting Efficiency by Vibration-Induced Stresses of Piezoelectric Patch Glued Tapered Beams
Authors: BOLAT Fevzi Çakmak
Published: July 2020

In this study, the effects of taper ratio and boundary conditions on the energy harvest performance of a beam element were examined. For these purpose, different taper ratio beams were analyzed numerically. The energy harvesting process was achieved by gluing a piezoelectric patch onto the cantilever tapered beam. Different taper ratio beams were designed and the effects of these taper ratio on stress change were investigated. In piezoelectric materials, when mechanical stress or strain is applied to the material, they generate electrical potential energy as a response. In order to increase the stresses on the tapered beam, the boundary condition was applied to be the thin edge of the tapered beam element in this study. In this way, the effect of tip mass was created and it was aimed to increase the stress magnitude due to vibration on the beam. Stress changes and displacement magnitudes of beams examined by applying load on beams having different taper ratio. The effect of these alterations on energy harvest efficiency was analyzed.
KONFIGURASI RUANG BERDASARKAN KUALITAS KONEKTIVITAS RUANGAN DALAM PERANCANGAN KANTOR: SPACE SYNTAX ANALYSIS
Authors: Permana Asep Yudi , Permana Aathira Farah Salsabilla , Andriyana Deka
Published: July 2020

Abstract: The complexity that occurs in an office is determined by the diversity and intensity of user activity. Connectivity system becomes an important factor to accommodate activities in their work, especially connectivity from private work areas to shared work areas and public services. This study aims to analyze the activities of employees and their connectivity, including the flow of circulation in the office of PT. Haleyora Powerindo after undergoing a re-design and evaluation for 5 months after office operations. Space Syntax Analysis is done to see how changes in behavior and connectivity occur. Data is collected by direct observation and review of secondary sources related to the development and changes that occur in the office. It was concluded that connectivity and permeability in the design of an office require a comfortable circulation area with a range that is not too long between nodes as an observation room with a path as a circulation area.Keywords: Behavior, Space, conectivity, permeability, office. Abstrak: Kompleksitas yang terjadi di dalam sebuah perkantoran ditentukan oleh keragaman dan intensitas aktivitas penggunanya. System konektivitas menjadi faktor penting untuk mengakomodasi kegiatan dalam pekerjaannya, terutama konektivitas dari area kerja pribadi ke area kerja Bersama dan layanan publik. Penelitian ini berutujuan untuk menganalisis aktivitas pegawai dan konektivitasnya termasuk alur sirkulasi di kantor PT. Haleyora Powerindo setelah mengalami re-desain dan dilakukan evaluasi selama 5 bulan pasca operasional kantor. Space Syntax Analysis dilakukan untuk melihat bagaimana perubahan perilaku dan konektivitas yang terjadi. Data dikumpulkan dengan observasi langsung dan review sumber sekunder yang terkait dengan pengembangan dan perubahan yang terjadi di kantor tersebut. Disimpulkan bahwa konektivitas dan permeabilitas pada rancangan sebuah kantor memerlukan area sirkulasi yang nyaman dengan jangkau yang tidak terlalu panjang antara node sebagai ruang pengamatan dengan path sebagai area sirkulasi.Kata Kunci: Perilaku, Ruang, Konektivitas, Permiabilitas, Kantor
The conditions of existence with probability one of generalized solutions of Cauchy problem for the heat equation with a random right part
Authors: Slyvka-Tylyshchak A.
Published: July 2020

The subject of this work is at the intersection of two branches of mathematics: mathematical physics and stochastic processes. The influence of random factors should often be taken into account in solving problems of mathematical physics. The heat equation with random conditions is a classical problem of mathematical physics. In this paper we consider a Cauchy problem for the heat equations with a random right part. We study the inhomogeneous heat equation on a line with a random right part. We consider the right part as a random function of the space Subφ(Ω). The conditions of existence with probability one generalized solution of the problem are investigated.
IMPROVED METHODOLOGY OF APPLICATION OF THE OBJECT MODEL INTERACTIONS OF DSP-SSP SYSTEMS THROUGH AD EXCHANGE
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Korotin Denys , Popereshnyak Svitlana ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Korotin Serhii ,   National Defense University of Ukraine, Kyiv, Ukraine
Published: July 2020

In the article analyzed the interaction of DSP-SSP systems through Ad Exchange. According to the results of the analysis, the purpose of scientific research is formed, which is that for automate process of the buying and selling of media content, to carry out simulations and to prove the feasibility of using the implemented platforms on the basis of the advanced method of application of the object model of interaction of DSP-SSP systems. The authors found that Ad Exchange is an intermediary between DSP and SSP platforms and implements the module one to many. Has been identified that this system enables the digital marketplace where publishers and advertisers come together to trade digital inventory. It is concluded that Ad Exchange is a standalone platform that facilitates and simplifies programmatic ads buying. The authors presented the model of the Ad Exchange system, presents advantages and disadvantages are indicated. It is concluded that the Validator block, which advertises only for a specific contingent of people, was first proposed by the authors as the most important component of this model. The Validator block is the main advantage of the system presented in the article over others. An advanced technique for the Validator block, the well-known DSP and SSP algorithm is improved. Based on the proposed model, a simulation was performed where the Validator block was implemented. It is concluded that Ad Exchange is a tool for automating the process of buying and selling Internet content. This allows you to earn more money and save time on transactions. The recommendations developed by the authors track poor quality proposals and deal with risks.
DETERMINATION OF PRIORITY OF CYBER SECURITY MEASURES AT INCOMPLETE EXPERT RANKINGS
Authors:   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine, Hnatiienko Hrygorii , Tmienova Nataliia ,   Taras Shevchenko National University of Kyiv, Kyiv, Ukraine
Published: July 2020

High-quality functioning of the information security system and solving problems that arise in the information protection, is currently a topical trend in various areas of human life. Successful cyber protection consist in creating and implementing a multi-level system of measures that cover various aspects with complex interact and complement each other. These measures have a different nature, and their priorities may differ significantly in terms of different services of the organization, so it is logical to formalize the sequence of cybersecurity implementation in a class of group choice tasks. The paper proposes a flexible mathematical apparatus for modeling information security problems and adequate application of the opinion analysis of experts’ team in practice. The approach to finding the resultant ranking of measures priority is described as a solution to the problem of multicriteria optimization, where the sequence of measures implementation may involve the interaction of performers and require regulation of the actions sequence of all elements and subsystems of the organizational system. This approach allows to combine different information security measures proposed by the experts of various departments; to find a compromise solution for a diverse group of experts; not to violate any expert's preferences under calculating the compromise ranking of cyber security measures. The proposed approach can be useful in developing appropriate cybersecurity measures and favorable in developing and implementing of rapid response procedures to threats, as well as it can be indispensable in the overall building or improving organization security system and it can contain elements of training, coordination, and complexity of expert team members, who are the heads of units of a single organizational system.
Changing the tactics of x-ray endovascular treatment of patients with acute coronary syndrome with intermediate and severe degrees of severity of coronary lesions on the SYNTAX scale in the conditions of the COVID-19 pandemic.
Authors: Bocharov A. V. , Popov Leonid V.
Published: July 2020

The article reflects changes in the structure of interventional interventions in patients with acute coronary syndrome in the conditions of the COVID-19 pandemic and suggests changes in the tactics of x-ray endovascular treatment of this category of patients
Adão 3
Authors: Grzybowski Adam , Goldman Luis
Published: July 2020

Adão 3
Refratário
Authors: Schechtman Alfredo
Published: July 2020

Refratário
Entre a lembrança e o esquecimento: a Shoá na literatura brasileira
Authors: Waldman Berta
Published: July 2020

O propósito deste artigo é refletir sobre alguns exemplos de como a literatura brasileira configurou as atrocidades perpetradas durante a Segunda Guerra Mundial, a Shoá, posicionando-se em relação à lembrança e ao esquecimento.
Coleção e memória em "Uma vida iluminada", de Liev Schreiber
Authors: Maia Claudia
Published: July 2020

O filme Uma vida iluminada (2005), com roteiro e direção de Liev Schreiber, baseado no romance Tudo se ilumina, de Jonathan Safran Foer, narra a história de um jovem judeu norte-americano que viaja para a Ucrânia em busca de seu passado. A coleção para o protagonista do filme e para a mulher que ele encontra em Trachimbrod, sobrevivente de um massacre que destruiu toda a sua família, é de fundamental importância. Ambos os personagens reúnem objetos como forma de lutar contra a dispersão e o esquecimento, assim como argumentou Walter Benjamin sobre o colecionador. Em Uma vida iluminada, essa luta está intrinsecamente ligada à memória judaica, constantemente ameaçada por regimes totalitários.
Phenotypic methods for detection of Amp C b lactamases in Gram negative clinical isolates of a tertiary care hospital
Authors: Inamdar Dhanashree P , B Anuradha
Published: July 2020

: ESBLs (Extended spectrum beta lactamases) are detected routinely in most laboratories but Amp c Beta lactamases are neglected to large extent. Pseudosusceptibility seen in Amp C producers leads to resistance to extended-spectrum cephalosporins resulting in inappropriate antimicrobial regimens and therapeutic failure. Thus, there is a need to know an appropriate phenotypic method for easy detection of Amp C β-lactamases as they have clinical relevance.

: To detect and compare different phenotypic methods for Amp C β-lactamases in Gram-negative clinical isolates of Enterobacteriaceae family

A prospective study was done at Mamata Medical college, Khammam for period of three months. Phenyl boronic acid method, Cefoxitin Cloxacillin-Double disc synergy test, TRIS EDTA method, Disc approximation test were done on isolates after screening by Cefoxitin disc.

: Out of 140 isolates tested, 80(57%) were positive (resistant) for screening test by cefoxitin. Out of them 61(76.2%) were Escherichia coli, 16 (20.1%) isolates were Klebsiella pneumoniae and 3 (3.75%) were Enterobacter sp. Phenotypic confirmatory methods by Cefoxitin Cloxacillin Double disc Synergy (CC-DDS) test showed zone difference of >4mm in 38(47.5%) isolates , by Phenylboronic acid method (PBA) > 5mm zone difference was observed in 34(42.5%) isolates, by TRIS EDTA method 32 (40%) showed indentation near EDTA disc and by Disc approximation test 32(40%) were positive for Amp C production. E coli was the commonest isolate showing Amp c production by all four methods.

: CC-DDS method has better detection rate compared to other phenotypic confirmatory methods. We suggest CC-DDS method as it is easy to perform.
EDUCAÇÃO EM SAÚDE PARA A CRIANÇA/JOVEM/FAMÍLIA: NECESSIDADES FORMATIVAS DOS ENFERMEIROS
Authors: Pereira Anabela Fonseca , Escola Joaquim José Jacinto , Almeida Carlos Manuel Torres
Published: July 2020

Objetivo: identificar necessidades de formação dos enfermeiros em Educação em Saúde para a criança/jovem/família. Método: pesquisa quantitativa aplicada a uma amostra de 311 enfermeiros que realizavam Educação em Saúde para a criança/jovem/família em dois centros hospitalares e dois agrupamentos de atenção primária da província de Trás-os-Montes e Alto Douro no segundo semestre de 2018. Resultados: entre os inquiridos, 84,9% (n=264) não seguia nenhum modelo/teoria de Educação em Saúde; 66,2% (n=206) não frequentou nenhuma formação no âmbito da Educação em Saúde nos últimos cinco anos; 98,7% (n=307) considerou que a formação em Educação em Saúde é importante para o seu desenvolvimento profissional; e 93,6% (n=291) referiu necessidade de formação específica no âmbito da Educação em Saúde, nomeadamente em “técnicas de comunicação” (50,5%; n=157) e “estratégias técnico-pedagógicas” (50,5%; n=157). Conclusão: os enfermeiros sentiam necessidade de formação em modelos/teorias, técnicas de comunicação e estratégias técnico-pedagógicas de intervenção na Educação em Saúde.

Descritores: Promoção da Saúde. Educação em Saúde. Enfermagem. Saúde da Criança. Saúde do Adolescente.

 
INCIDÊNCIA E CARACTERIZAÇÃO DAS FLEBITES NOTIFICADAS ELETRONICAMENTE EM UM HOSPITAL DE ENSINO
Authors: Mota Rosana Santos , Da Silva Valdenir Almeida , Mendes Andreia Santos , Barros Ângela De Souza , Dos Santos Olga Maria Brito , Gomes Bruno Pereira
Published: July 2020

Objetivo: analisar a incidência e as notificações de flebite em um hospital de ensino. Método: estudo observacional retrospectivo, realizado em Salvador, Bahia, Brasil. Os dados foram coletados com base nas notificações de incidentes relacionados à assistência à saúde, ocorridas no período de janeiro/2016 a dezembro/2017. Realizou-se análise descritiva. Resultados: foram notificados 277 casos de flebite, com incidência variando entre 1,45% e 26,09% no período do estudo. A maioria das flebites ocorreu em indivíduos adultos (63,27%); raça negra (66,06%); e com baixo nível de escolaridade (53,43%). O uso prolongado de medicamentos e/ou uso de medicamento irritante (52%) foram citados como principais causas do evento; 95,31% foram classificados como não graves. Conclusão: a incidência de flebite variou no período de estudo, e as notificações em um hospital de ensino apontaram para danos à saúde da maioria dos pacientes com flebites notificadas.

Descritores: Eventos Adversos. Flebite. Segurança do Paciente.
SIMULAÇÃO COMO ESTRATÉGIA DE ENSINO-APRENDIZAGEM NO TRATAMENTO DE FERIDAS: RELATO DE EXPERIÊNCIA
Authors: Molonha Alice , Fakhr Bruna De Oliveira , Custódio Felipe Amato , Lopes Thiago Pereira , Roecker Simone , Araujo Juliane Pagliari
Published: July 2020

Objetivo: relatar a experiência de estudantes do curso técnico em enfermagem sobre a utilização da simulação como estratégia de ensino-aprendizagem no tratamento de feridas. Método: relato de experiência de simulação no tratamento de feridas como estratégia de ensino-aprendizagem. Participaram 25 estudantes e 2 docentes de um curso técnico em enfermagem em um município paranaense. A simulação foi realizada nos meses de novembro e dezembro de 2019. Resultados: a simulação aplicada no tratamento de feridas desenvolveu-se em sete etapas. No decorrer das etapas, os participantes estudaram sobre feridas e prática de realização de curativos, confeccionaram as feridas e realizaram a simulação do cuidado. Conclusão: a experiência revelou que este método oferece benefícios no processo ensino-aprendizagem, favorece aos estudantes a oportunidade de uma atitude proativa na construção do conhecimento, bem como habilita-os e aproxima-os da prática profissional.

Descritores: Educação em Enfermagem. Ferimentos e Lesões. Ensino. Simulação.
Covid-19 Pandemisinde Düzce Üniversitesi Pandemi Yoğun Bakım Pratiği
Authors: AKBAŞ Türkay , EŞBAH Ali
Published: July 2020

COVİD-19 (SARS-CoV2) vakalarının yaklaşık %5’inde, ciddi hastalık nedeniyle yoğun bakım yatış ihtiyacı doğmaktadır. Genellikle pnömoniye bağlı akut respiratuar distres sendromu (ARDS) ile yatırılan bu hastaların çoğunda, invaziv mekanik ventilasyon ihtiyacı gelişmektedir. ARDS, yoğun bakım ünitelerinde takibi ve tedavisi zaman alan, özellikli bir hastalık grubunu oluşturmaktadır. COVİD-19 ile yatırılan, kritik hastaların viral yükleri fazla ve tedavi süreci uzun olduğundan, hastalardan sağlık çalışanlarına virüs bulaş riski de yüksektir. Hasta tedavileri ve invaziv girişimler esnasında, sağlık çalışanlarının kişisel koruyucu ekipman (eldiven, maske, bone, tulum, gözlük ve direkt solunum yolu temaslarında sperlikten oluşan koruyucu) giymeleri gerekmektedir. COVİD-19 pandemisi süresince, yoğun bakımdaki kritik COVID-19 hastaların takibiyle elde ettiğimiz tecrübeyi paylaşmak istedik.
Düzce COVID 19 PZR Testleri Nerede, Nasıl, Hangi Koşullarda Çalışılıyor?
Authors: ÖZTÜRK Cihadiye , ERDOĞAN Ziya , ATİK Dursun , ESEN Taner , DÖNMEZ Betül , MEMİŞ Nagihan , KESKİN Banu , KAYABAŞI Eda , KAYA Sare , KÖSE Ezgi , KAHRAMAN Gözde , DURAN Pelin , ÇALIŞKAN Emel , ÖKSÜZ Şükrü , ŞAHİN İdris
Published: July 2020

Çin’in Wuhan Eyaleti’nde 2019 Aralık sonlarında ilk olgular bildirildikten kısa bir süre sonra SARS CoV 2 tüm dünyaya yayılmış ve 12 Mart 2020’de Dünya Sağlık Örgütü tarafından pandemi ilan edilmiştir. Türkiye’de ilk olgu 10 Mart 2020’de, ilimizde ise 25 Mart 2020’de tespit edilmiştir. Düzce Üniversitesi Tıp Fakültesi Tıbbi Mikrobiyoloji Anabilim Dalı PZR Laboratuvarı 28.03.2020’den itibaren “T.C. Sağlık Bakanlığı Düzce yetkili Covid 19 PZR laboratuvarı” olarak görevlendirilmiştir. Örnekler Düzce’deki tüm il ve ilçe hastanelerinden, özel hastaneden ve halk sağlığı kurumumdan laboratuvarımıza gönderilmektedir. İlimizdeki tek Covid 19 merkezi burasıdır. Laboratuvarda 7 gün aralıksız çalışılmaktadır. Laboratuvarımızda Covid 19 antikor testleri, hızlı kart test ve ELİSA yöntemleri ile çalışılmaktadır. Laboratuvarımızda üç ay içinde toplam 8500 COVİD 19 PZR testi ve 2 haftalık süreçte 2200 anti Covid19 ELİSA total antikor testi çalışılmıştır. Hastanemizde artık covid 19 hastaları takip edilmemesine rağmen laboratuvarımızda pandemi süreci devam etmektedir. Ayrıca hastanenin tüm PZR çalışmaları, İFA çalışmaları da bu laboratuvar içinde yürütülmektedir.
A Cyclogram of an Energy Efficient Step of a Mobile Robotic System with Wheel-Walking Propulsion
Authors: Zhileykin M.M.
Published: July 2020

Mobile robotic systems are employed to perform a wide range of transportation and technological tasks. One of the main requirements to these systems is their high capability to traverse complex terrains and surfaces. Future applications of wheel-walking mobile systems largely define the problem of their energy efficiency. This paper presents a mobile robotic system with wheel-walking propulsion that can increase the system’s traverse capability on support surfaces with low bearing properties due to a new chassis layout and algorithms controlling the walking module. A cyclogram of the energy efficient step of the mobile robotic system with wheel-walking propulsion is developed, which provides high indicators of traverse capability on support bases with low bearing capacity.
The Main Trends in Developing Highly Reliable Communication and Control Systems for Unmanned Aerial Vehicles
Authors: Panteleymonov I.N. , Belozertsev A.V. , Monastyrenko А.А.
Published: July 2020

This work examines the problem of developing a highly reliable and universal communication and control system for unmanned aerial vehicles that provides uninterrupted operation regardless of the vehicles’ location and destination. For this purpose, it is proposed to create three digital data transmission networks: ground, air and satellite using a stack of TCP/IP protocols and modern methods of management, processing and display of information (SCADA-system). To improve reliability, survivability, stealth and noise immunity of the communication and control system of unmanned aerial vehicles it is proposed to transmit information in the optical and radio bands.
Pola Komunikasi Dakwah Wahdah Islamiyah di Kabupaten Sinjai, Sulawesi Selatan
Authors: Suriati Suriati
Published: July 2020

The development of information technology has influenced patterns of social interaction. This should be responded by the da'wah institutions in carrying out their proselytizing (da'wah) activities. The practice of da'wah has so far been running but it is often less optimal in applying communication patterns due to unclear control groups and the difficulties in evaluating movements. As a religious organization, Wahdah Islamiyah organization in Sinjai, South Sulawesi is very active in doing proselytizing activities to the people. This study aimed at uncovering the communication patterns adopted by Wahdah Islamiyah in delivering its da'wah messages in Sinjai and how it is developed and accepted by people living in remote villages. This is a qualitative research, using the methods of da’wah communication and sociological approaches. Data were collected by conducting observation, interview, and documentation and analyzed through the process of of data reduction, data display and drawing conclusions. The results of the study found that the communication patterns applied by Wahdah Islamiyah in Sinjai consists of control groups communication in which the organization controls the Muslim preachers (da’i) and da’wah materials; tarbiyah communication by using a tiered curriculum system in learning; cadre pattern through guidance to cadres; and network communication, namely recruiting new members
Epidemiology of traumatic brain injury in children under dynamic urbanization conditions
Authors: Gaibov Saydi S.-H. , Zacharchyk Ekaterina V. , Vorobyev Dmitriy P. , Lebedev Ilya A. , Kim Rina T. , Minchenkova Anastasiya N.
Published: July 2020

Introduction. To optimize measures to improve neuro-traumatological care, it is necessary to rely on data from epidemiological studies. Materials and methods. There was performed a retrospective analysis of 2436 traumatic brain injury (TBI) cases in children aged 0-17 years, of which 1,443 (59.2%) were boys, 993 (40.8%) were girls. Results. In the Tyumen region for the period 2013-2019, the incidence of TBI in children remained relatively constant and its average value was 1.07 per 100,000 children. The most common head injury was found in male children patients to be of 1143 (59.2%). TBI among female children patients over 7 years decreased by 11.2%, and among male children patients increased by 10.9%. A sharp increase in head injury is observed in the first year of an infant life as much as 656 (26.9%) cases of head injury. The mortality rate from TBI in children was of 2.5 per 100,000 children, and the mortality rate accounted for 3.3 per 1000 children over the entire period. Conclusion. The analysis can allow conducting larger epidemiological studies, as well as to organize and improve the quality of care for TBI children patients.
Micronutrients availability, immune response, and COVID-19
Authors: Fisenko Andrey P. , Makarova Svetlana G.
Published: July 2020

Vaccination and hygiene are currently the main strategies for helping limit the spread and impact of acute respiratory infections. However, the pandemic of SARS-CoV-2 infection and its severe consequences require the search for additional measures for reducing the morbidity and mortality from coronavirus infection. One of these additional prevention strategies is micronutrient status optimization, which is safe and cost-effective. Vitamins and minerals are important components of the immune response. The effect of micronutrients such as vitamin D, ascorbic acid, zinc, omega-3 polyunsaturated fatty acids on the immune response has been studied for several decades. As a result, significant shreds of evidence have been accumulated regarding the importance of provision immuno-nutrients on the adequate immune response. This implies in both contexts: the prevention of infectious diseases and their course. At the same time, the problem of insufficient supply with various micronutrients is gaining global significance, affecting every country and every socio-economic class of people. This review contains data on the state of micronutrient status of the global and Russian population, discussion of the role of key immunonutrients in the prevention and treatment of respiratory infections, and results of recent meta-analyses. It will also provide recommendations of experts in the field of nutrition, developed in 2020 with regard to the COVID-19 pandemic.
Chronic abdominal syndrome with localization in the right iliac region in children: surgical aspects
Authors: Khvorostov Igor N. , Sinitsyn Aleksey G.
Published: July 2020

The review presents up-to-date data on pathophysiology, principles of diagnosis, and surgical treatment of chronic abdominal syndrome (CAS) with localization in the right iliac region (HASRIR) in children. There are summarized data on histological changes proving the relationship between appendix pathology and localized pain in the right iliac region in children. The sensitivity, specificity, and information content of laparoscopy in the diagnosis of the causes of periodic pain in the right iliac region were shown to reach 90.9%. Significant macroscopic signs of CAS during laparoscopy are as follows: adhesions involving the process, its rigidity, palpable fecal stones, process atrophy, process wall diverticula, mucocele. If these symptoms are found in HASRIR patients, it is recommended to perform laparoscopic appendectomy
Early diagnosis of Cantrell’s Pentalogy in a newborn baby
Authors: Kharitonova Nataliya A. , Basargina Milana A. , Evloeva Khadizhat S.
Published: July 2020

A clinical case of early diagnosis of Pentalogy of Cantrell (POC) in a newborn infant is presented. The features of the formation of the defect and its classification are described. A crucial role in verifying the diagnosis was performed by CT scan with intravenous contrast, which revealed a narrowing of the pulmonary artery trunk; located subcutaneously above the umbilical ring, the diverticulum of the left ventricle of the heart, originating from the apical section of the left ventricle and connected to its cavity by a linear isthmus located along the middle line, as well as a local defect of the diaphragm in the anterior section. Taking into account the accumulated experience, it is generally recognized that when establishing this diagnosis in the first trimester, termination of pregnancy is more preferable. Therefore, parents should be notified of a possible adverse outcome in a timely manner. The presented observation reflects the high importance of early diagnosis of congenital forms of combined pathology in children, requiring the use of modern research methods to determine the tactics and conduct timely effective treatment.
INFLUÊNCIA DE DETERMINANTES SOCIOECONÔMICOS, AMBIENTAIS E DEMOGRÁFICOS NA DISTRIBUIÇÃO ESPACIAL DA DENGUE
Authors: Dos Santos Diego Fonseca , Mendes Thiago Augusto , Moreira Pedro Augusto Gonzaga
Published: July 2020

A dengue e suas variantes tornaram-se grande problema de saúde pública em âmbito internacional. Como a complexidade da distribuição da dengue está intimamente relacionada com as características ecológicas do ambiente, os Sistemas de Informações Geográficas (SIG’s) mostram-se como importante ferramenta na operacionalização da prevenção e do combate à doença. Com isso, objetivou-se correlacionar espacialmente os casos de dengue notificados com os fatores socioeconômicos, ambientais e demográficos a partir dos índices de Moran Global (I) e Local (LISA), aplicado através do software Geoda, a fim de identificar o perfil de áreas com maior probabilidade de manifestação da dengue para subsidiar ações de prevenção, controle e aplicação de recursos. Foram encontrados baixos valores de autocorrelação espacial bivariada (-0,2177 a 0,1023), entretanto, as análises dos mapas Moran LISA apresentaram padrões de distribuição espacial em forma de aglomerados para as variáveis renda média por domicílio, percentual de domicílios com abastecimento de água, com coleta de lixo regular e ocupação horizontal.