bluuebunny/crossref_metadata_2025 huggingface dataset:
Upper Gastrointestinal Sensitization And Symptom Generation
Authors: Suciu Alina ,   Second Medical Department “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania, Popa Stefan-Lucian ,   Second Medical Department “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania,   Stefan-Lucian Popa, Second Department, Clinicilor Street, No. 2-4, RO 400006, Cluj-Napoca, Cluj Napoca, Romania, Mobile: +40755 855 262, Email: popa.stefan@umfcluj.ro, Lucian Dumitrascu Dan ,   Second Medical Department “Iuliu Hatieganu” University of Medicine and Pharmacy Cluj-Napoca, Romania
Published: November 2022

Functional gastrointestinal disorders (FGIDs) are a highly prevalent group of heterogeneous disorders, and their diagnostic criteria are symptom-based, with the absence of anatomical and biochemical abnormalities of the gastrointestinal tract. Chronic visceral symptoms are common both in patients with an identifiable organic disease but also in FGID patients. Patients suffering from upper gastrointestinal functional disorders typically present with various symptoms such as early satiety, postprandial fullness, bloating, nausea, vomiting, and epigastric pain. Considering their increasing prevalence, difficulties in diagnosis, and low quality of life, FGIDs have become an emerging problem in gastroenterology. We aimed to provide an updated summary of pathways involved in visceral sensitization. We examined the recent literature searching for evidence of the most important studies about the mechanisms underlying gastrointestinal symptom generation and sensitization.
Resident physicians’ and Midwives’ Knowledge of Preeclampsia and Eclampsia Reflected in Their Practice at a Clinical Hospital in Southern Romania
Authors: Liliana Soggiu-Duta Carmen ,   Department of Obstetrics-Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Carmen Liliana Soggiu-Duta, Department of Obstetrics Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania, E-mail: dr.lilianasoggiu@gmail.com, Suciu Nicolae ,   Department of Obstetrics-Gynecology, Carol Davila University of Medicine and Pharmacy, Bucharest, Romania,   Department of Obstetrics-Gynecology, Alessandrescu Rusescu Institute for Mother and Child Care, Bucharest, Romania
Published: November 2022

Romania has drastically improved an array of health indicators in recent years, including maternal mortality rates, which decreased from 1990 to 2015, but the mortality rates are still high, ranking among the first in Europe. Preeclampsia and eclampsia constitute one of the primary causes of maternal death in the country. The study was conducted from early January to the end of February 2019 to assess the current state of resident physicians’ and midwives’ knowledge of preeclampsia and eclampsia reflected in their practice at a clinical hospital in southern Romania. Self-administered questionnaires were used for data collection.

Most of the investigated resident physicians and midwives (87.5%) answered correctly regarding the correct definition of preeclampsia. The first choice of procedure for the patient with preeclampsia (vaginal delivery or C-section) was chosen correctly by only 37.5% of the participants. Regarding the correct identification of the necessary paraclinical tests used for women with suspected preeclampsia, 58.3% of the participants answered correctly. As far as the correct identification of the possible risks of dexamethasone administration to mothers is concerned, only 29.2% of the participants answered correctly. Also, 58.3% of the participants answered correctly regarding the correct identification of contraindicated uterotonic drugs for women with diagnosed hypertension.

Resident physicians and midwives are aware of pregnancy complications, but they hold limited knowledge specific to pregnancy complications as preeclampsia and eclampsia. It is imperative to promote studies to evaluate the impact of enhancing their training to include additional content related to the early detection and management of preeclampsia and eclampsia.
MPLEMENTASI PENGOLAHAN CITRA PADA ROBOT OTONOM PENGUMPUL BOLA TENIS MEJA
Authors: Julianto Fikri Refo , Romdlony Muhammad Zakiyullah , Cahyadi Willy Anugrah
Published: November 2022

Tenis meja merupakan salah satu cabang olahraga bola kecil yang diminati banyak orang. Dalam latihan tenis meja, seorang pemain akan menggunakan banyak bola sebagai alat latihan. Perlu usaha lebih bagi para pemain yang berlatih untuk mengumpulkan bola-bola yang berserakan setelah latihan. Ada banyak alat yang diciptakan untuk mempermudah pengambilan bola-bola tersebut, namun proses pengambilannya masih manual karena menggunakan tenaga pemain itu sendiri. Untuk meringankan usaha pemain, diperlukan suatu sistem yang otomatis dalam pengumpulan bola tenis meja. Hal itu akan diwujudkan dengan perancangan robot otonom pengumpul bola tenis meja. Robot ini akan menggunakan pengolahan citra dalam pendeteksian bola tenis meja. Proses ini berguna untuk menentukan jarak robot ke bola, dan juga menjadi acuan untuk pembuatan path planning. Robot ini akan mengumpulkan bola tenis meja yang berserakan berdasarkan jalur yang sudah dibuat. Dengan begitu, pemain tidak perlu mengeluarkan usaha lebih untuk mengambil bola-bola yang berserakan. Tingkat akurasi pada penelitian ini dalam pendeteksian bola dan jarak mencapai 80%.
Kata Kunci: tenis meja, robot otonom, pengolahan citra
Baptism of Stillborn Babies? A South African Methodist Perspective
Authors: Dreyer Wim , Sekhejane Moagi
Published: November 2022

Many rituals in Africa are deeply rooted in the cultural beliefs, traditions and indigenous religions of the continent. The rituals are guided by people’s belief in their existence after death, and the role of the living dead or ancestors. These African rituals have been infused by Christian, Muslim and Western concepts. Death rituals and the mourning practices of Africans are varied because of the existence of so many religious and cultural practices on the African continent. Many African families will engage in one way or another in some cleansing rituals after the death of a loved one including a stillborn. In the Methodist Church of Southern Africa (MCSA), no records of stillbirth baptism are kept in the Church archives, nor is there any pastoral guidance or liturgy available to assist grieving families regarding stillbirth. It is questionable whether stillbirth baptism should be allowed, in light of the fact that there is no record whatsoever from either the Old Testament or the New Testament which allows for this rite of passage. It is also clear that stillbirth baptism does not have a theological base.
Biologic Treatment of Psoriasis and Tuberculosis Testing: A Retrospective Analysis
Authors: Batchelder Emma , Trifoi Mara , Hong Julie , Maczuga Steven , Kirby Joslyn
Published: November 2022

Background: Current recommendations for biologic use in psoriasis recommend baseline TB screening with IGRA. Studies have found in low TB prevalence countries that TB conversion occurs at low rates in those utilizing biologic therapies.

Objectives: To evaluate utilization and cost effectiveness of TB testing in patients with psoriasis being treated with biologics.

Methods: We retrospectively queried a national commercial claims database (Truven Health MarketScan) from 1/1/2014 to 12/31/2018 to investigate the use of TB screening and disease prevalence among patients with psoriasis being treated with a biologic agent. Inclusion criteria consisted of psoriasis disease status, continuous utilization of a biologic for one year prior and three years after the first biologic claim; and no claims for TB within the year prior to starting the biologic.

Results: 3,421 patients with psoriasis and concurrent biologic treatment use were included in the study. 84.7% (2,897) had a baseline TB test within 15 months prior to first claim of biologic use. Baseline tests were primarily IGRA (75.8%, n=2,195) with PPD tests only being used in 24.2% (n = 702) of patients. Total cost for baseline TB test in the cohort amounts to $738,117. TB was diagnosed in 4.1% (n = 147) patients and TNF- α inhibitors was the most frequently prescribed biologic.

Conclusions: The majority of patients diagnosed with psoriasis had a claim for baseline TB testing. Current recommendations surrounding biologics and TB screening should take into account the high cost of baseline TB testing and the low rate of TB prevalence among patients on biologics.
A Phase 2 Study of Oral Difelikefalin for Moderate-to-Severe Pruritus in Subjects With Notalgia Paresthetica (KOMFORT)
Authors: Kim Brian S , Bissonnette Robert , Nograles Kristine , Munera Catherine , Shah Nilam , Jebara Alia , Cirulli Joshua , Goncalves Joana , Lebwohl Mark
Published: November 2022

N/A
Deucravacitinib long-term efficacy and safety in plaque psoriasis: 2-year results from the phase 3 POETYK PSO program
Authors: Warren Richard , Sofen Howard , Imafuku Shinichi , Szepietowski Jacek , Blauvelt Andrew , Spelman Lynda , Toms Jessica , Buck Alex , Banerjee Subhashis , Menter Alan
Published: November 2022

N/A
Tapinarof Cream 1% Once Daily for Plaque Psoriasis: Improvements in Quality of Life and Clinical Efficacy in Two Pivotal Phase 3 Trials
Authors: Stein Gold Linda , Griffiths Christopher E , Tallman Anna M , Brown Philip M , Lebwohl Mark
Published: November 2022

N/A
Evaluating treatment choice among patients with moderate or severe psoriasis in the United States
Authors: Armstrong April W , Jayade Sayeli , Rege Sanika , Joshi Namita , Patel Vardhaman , Davidson David , Kalirai Samaneh , Wolin Daniel , Boyle Kimberly , Patel Dipen , Seigel Lauren
Published: November 2022

N/A
Bilateral talocalcaneal tarsal coalition with flatfeet treated with single-stage coalition resection and calcaneal lengthening osteotomy: A case report
Authors: Alabdulkareem Abdulrahman I. , Alkhalife Yasser I. , Bayounis Abdulaziz M. , Shabib Abdullah A. B. , Alrogy Waleed A. , Al-Jahdali Fares H. , Alsayegh Samir O.
Published: November 2022

A coalition is a bridge connecting osseous structures. Tarsal coalitions typically involve talocalcaneal and calcaneonavicular joints. As a result, patients might present with pain and/or rigid flatfoot deformity. We outline a case of bilateral middle facets talocalcaneal tarsal coalition with rigid flatfeet who was treated with resection combined with flatfoot reconstruction. the patient was an 11-year-old Saudi girl who had progressive bilateral flatfoot for which non-operative treatment failed. A single-stage middle facet talocalcaneal coalition resection with concomitant Evans calcaneal lengthening osteotomy and gastrocnemius recession was performed. Postoperatively, the American Orthopaedic Foot and Ankle Society (AOFAS) ankle midfoot score was measured, and the patient had a score of 90/100. The outcome was satisfactory, and the other foot was operated on 6 months later, with the same procedure and outcome (AOFAS: 90/100). Six years of follow-up showed no recurrence and a satisfactory lifestyle with no activity limitation. We aimed to highlight the AOFAS score 6 years after resecting the coalitions while reconstructing the foot in a single-staged procedure.
Quasi-reversible photoinduced displacement of aromatic ligands from semiconductor nanocrystals
Authors: Yoshioka Daisuke , Yoneda Yusuke , Chang I-Ya , Kuramochi Hikaru , Hyeon-Deuk Kim , Kobayashi Yoichi
Published: November 2022

Organic-inorganic nanohybrids using semiconductor nanocrystals (NCs) coordinated with aromatic organic molecules have been widely studied in the fields of optoelectronic materials, such as solar cells, photocatalysis, and photon upconversion. In these materials, coordination bonds of ligand molecules are usually assumed to be stable during optical processes. However, this assumption is not always valid. In this study, we demonstrate that the coordination bonds between ligand molecules and NCs by carboxyl groups are displaced quasi-reversibly by light irradiation using zinc sulfide (ZnS) NCs coordinated with perylenebisimide (PBI) as a model system. Ultrafast spectroscopy and density functional theory calculations show that the photoinduced ligand displacement is driven by ultrafast hole transfer from PBI to ZnS NCs, and that the dissociated radical anion of PBI survives over the second timescale. This study opens up a new avenue for advanced photofunctional materials utilizing colloidal NCs, such as photocatalysts that can expose their active facets of NCs on demand, and sub-micropatterning of photoconductive circuits on solid-state NC films.
Effect of buffers and pH in antenna sensitized Eu(III) luminescence
Authors: Nielsen Lea Gundorff , Sørensen Thomas Just
Published: November 2022

The photophysics of a europium(III) complex of 1,4,7,10-tetraazacycododecane-1,4,7-triacetic acid-10-(2-methylene)-1-azathioxanthone is investigated in three buffer systems and at three pH values. The buffers—phosphate buffered saline (PBS), HEPES, and universal buffer—had no effect on the europium luminescence, but a lower overall emission intensity is determined in HEPES. It is found that this is due to quenching of the 1-azathioxanthone first excited singlet state by HEPES. The effect of pH on the photophysics of the complex is found to be minimal, and protonation of the pyridine nitrogen was found to be irrelevant. Even so, pH is shown to change the intensity ratio between 1-azathioxanthone fluorescence and europium luminescence. It is concluded that the full photophysics of a potential molecular probe should be investigated to achieve the best possible results in any application. For instance moving from HEPES to PBS improves the signal of the investigated europium(III) complex significantly.
A machine learning q-RASPR approach for efficient predictions of the specific surface area of perovskites
Authors: Banerjee Arkaprava , Gajewicz-Skretna Agnieszka , Roy Kunal
Published: November 2022

In this study, the specific surface area of various perovskites was modeled using a novel quantitative read-across structure-property relationship (q-RASPR) approach, which clubs both Read-Across (RA) and quantitative structure-property relationship (QSPR) together. After optimization of the hyper-parameters, certain similarity-based error measures for each query compound were obtained. Clubbing some of these error-based measures with the previously selected features along with the Read-Across prediction function, a number of machine learning models were developed using Partial Least Squares (PLS), ridge regression (RR), linear support vector regression (LSVR), and random forest (RF) regression. Based on the external prediction quality and interpretability, the PLS model was selected as the best predictor which underscored the previously reported results. The finally selected model should efficiently predict specific surface areas of other perovskites for their use in photocatalysis. The new q-RASPR method also appears promising for the prediction of several other property endpoints of interest in materials science.
Theory, implementation, and disappointing results for two-photon absorption cross sections within the doubly electron-attached equation-of-motion coupled-cluster framework
Authors: Nanda Kaushik , Gulania Sahil , Krylov Anna
Published: November 2022

The equation-of-motion coupled-cluster singles and doubles method with double electron attachment (EOM-DEA-CCSD) is capable of computing reliable energies, wave functions, and first-order properties of excited states in diradicals and polyenes that have significant doubly excited character with respect to the ground state without the need for including the computationally expensive triples excitations. Here, we extend the capabilities of the EOM-DEA-CCSD method to the calculations of a multiphoton property, two-photon absorption (2PA) cross sections. Closed-form expressions for the 2PA cross sections are derived within the expectation-value approach using response wave functions. We analyze the performance of this novel implementation by comparing the EOM-DEA-CCSD energies and 2PA cross sections with those computed using the CC3 quadratic response theory approach. As the benchmark system, we consider transitions to the states with doubly excited character in twisted ethene and in polyenes for which EOM-EE-CCSD (EOM-CCSD for excitation energies) performs poorly. The EOM-DEA-CCSD 2PA cross sections are comparable with the CC3 results for twisted ethene; however, the discrepancies between the two methods are large for hexatriene. The observed trends are explained by configurational analysis of the 2PA channels.
Structure-based design of biocatalytic panels for pharmaceuticals synthesis
Authors: YU YUQI , Rue Casamajo Arnau , Finnigan William , Schnepel Christian , Barker Rhys , Morrill Charlotte , Heath Rachel , De Maria Leonardo , Turner Nicholas , Scrutton Nigel
Published: November 2022

Biocatalysis is emerging as an attractive option for manufacturing pharmaceuticals. However, the identification of enzymes for target transformations of interest requires major screening efforts. Here we report a structure-based computational workflow to prioritize protein sequences by a score based on predicted activities on substrates, thereby reducing resource intensive laboratory-based biocatalyst screening. We selected imine reductases (IREDs) as a class of biocatalysts to illustrate the application of the computational workflow termed IREDFisher. Validation by using published data showed that IREDFisher can retrieve the best enzymes and increase the hit rate by identifying the top 20 ranked sequences. The power of IREDFisher is confirmed by computationally screening 1,400 sequences to identify suitable biocatalysts for five selected reductive amination reactions. IREDFisher is available as a user-friendly web interface that will enable rapid identification of biocatalysts for applications in synthesis and directed evolution studies with minimal time and resource expenditure.
STUDYING THE FEATURES OF THE VALUE-SEMANTIC SPHERE OF EMPLOYEES OF AN EDUCATIONAL ORGANIZATION IN THE CONDITIONS OF DIGITALIZATION
Authors: Топорнина Анна Вячеславовна
Published: November 2022

Приведены результаты изучения особенностей ценностно-смысловой сферы сотрудников образовательной организации в условиях цифровизации. На основе теоретической модели изучения ценностно-смысловой сферы сотрудников образовательной организации в условиях цифровизации осуществлены формулирование критериев, обоснование и подбор диагностического инструментария. На примере пилотажного исследования, в ходе которого были изучены показатели ЦСС преподавателей, ИТ-специалистов и учебно-вспомогательного персонала, работающих в одном из государственных университетов, проиллюстрирована методика исследования и показаны результаты выявленных особенностей ЦСС.

The article presents the results of studying the features of the value - semantic sphere of employees of an educational organization in the conditions of digitalization. On the basis of the theoretical model of studying the value - semantic sphere of employees of an educational organization in the conditions of digitalization, the formulation of criteria, justification and selection of diagnostic tools were carried out. Using the example of a pilot study, during which the indicators of the CSSS of teachers, of IT specialists, teaching and support staff working at one of the state universities were studied, the research methodology was illustrated and the results of the identified features of the CSSS were shown.
PECULIARITIES OF SOCIAL-PSYCHOLOGICAL SATIETY WITH THE CONDITIONS OF LIFE IN A MEGA CITY IN DIFFERENT GROUPS OF CITIZENS
Authors: Дробышева Татьяна Валерьевна , Ларионов Иван Викторович , Тарасов Семен Васильевич
Published: November 2022

Рассмотрена проблема изучения особенностей социально-психологической пресыщенности в группах горожан с разной территориальной принадлежностью (москвичей и жителей Подмосковья). Предположили, что в группе москвичей пресыщенность выражается в неэмоциональном восприятии городской среды и стратегиях избегания навязанного общения, а в группе жителей Подмосковья - в амбивалентных переживаниях, стратегиях избегания чрезмерной информатизации. Данные различия обусловлены городской идентичностью и территориальной принадлежностью респондентов (место проживания). В работе применяли авторские методики, направленные на выявление аффективного, когнитивного и поведенческого компонентов социально-психологической пресыщенности, анкетирование и опросник городской идентичности М. Лалли. Полученные результаты позволили подтвердить выдвинутую гипотезу. Москвичи, осознавая неблагоприятность условий жизни в городе, подавляют эмоциональные переживания, изменяют и ограничивают социальные контакты. Жители Подмосковья, сталкиваясь с навязанными городской средой информационными и коммуникативными источниками пресыщенности, стремятся оградить себя от них, «психологически капсулируясь».

Article is devoted to a problem of experiencing social-psychological satiety among residents with different territorial identity (city dwellers and suburbanites in Moscow). We suggested that in group of city dwellers (Muscovites) satiety is expressed in unemotional perception of city environment and strategies of avoiding imposed communication, in group of suburbanites (living in satellite cities) - in ambivalent experiences, strategies of avoiding imposed informatization. These differences are due to city identity and territorial affiliation (place of living). The author's methods were used in the work, aimed at identifying the affective, cognitive and behavioral components of social-psychological satiety, questioning method and city identity questionnaire (M. Lalli). The obtained results allowed us to confirm the put forward hypothesis. City dwellers are Muscovites suppress emotional experiences, change and limit social contacts when they realize the unfavorable living conditions in the city. Suburbanites seek to protect themselves by «psychologically encapsulating» when confronted with information and communication sources of satiety imposed on the urban environment.
POINT-RATING CONTROL OF CADETS KNOWLEDGE IN THE PROCESS OF MILITARY PROFESSIONAL EDUCATION
Authors: Шиленин Денис Александрович
Published: November 2022

Рассматриваются вопросы внедрения балльно-рейтингового контроля знаний курсантов в военно-профессиональном образовании. Вопросы внедрения балльно-рейтингового контроля рассматриваются как один из способов повышения качества подготовки будущих офицеров. На основе изучения научной литературы в статье раскрывается практический опыт применения в российских военных вузах балльно-рейтингового контроля, главной задачей которого является активизация учебной работы курсантов и повышение мотивации к получению высокой оценки на занятиях в течение всего периода обучения. По итогам проведенного исследования были получены результаты, которые раскрывают, что внедрение балльно-рейтингового контроля способствует более объективной оценке успеваемости курсантов в целом, а также учитывает те виды деятельности курсанта, которые не могут охватить аудиторные часы. Вместе с тем было выявлено, что перспективным направлением развития балльно-рейтингового контроля в военных институтах является решение вопросов информационно-методического обеспечения, механизмов поощрения курсантов и популяризации самой системы контроля в целом.

The article discusses the issues of the introduction of point-rating control of cadets' knowledge in military vocational education. The issues of implementing point-rating control are considered as one of the ways to improve the quality of training of future officers. Based on the study of scientific literature, the article reveals the practical experience of using point-rating control in Russian military universities, the main task of which is to activate the educational work of cadets and increase motivation to receive high marks in the classroom during the entire training period. Based on the conducted research, the results were obtained, which reveal that the introduction of point-rating control contributes to a more objective assessment of the performance of cadets as a whole, and also takes into account those types of cadet activities that cannot cover classroom hours. At the same time, it was revealed that a promising direction for the development of point-rating control in military institutions is to address issues of information and methodological support, mechanisms for encouraging cadets and popularization of the control system itself as a whole.
FORMING PROFESSIONAL SOCIAL WORK IN THE CONTEXT OF POSTMODERNISM DISCOURSES: EVALUATION OF DYNAMICS FROM 1991 TO 2000
Authors: Фирсов Михаил Васильевич , Лельчицкий Игорь Давыдович , Черникова Анна Андреевна , Ивлева Светлана Анатольевна
Published: November 2022

Изучается проблема становления профессиональной социальной работы в России с начала 1990-х по 2000 гг. Проанализированы изменения, связанные с процессами десоветизации российского общества; определён доминирующий объект помощи социальных служб - индивид, категории граждан для предоставления специфических услуг и институциональной поддержки: беженцы, безнадзорные, безработные, дети, находящиеся в трудной жизненной ситуации, дети оставшиеся, без попечения родителей. Показана роль государства и действующего законодательства в деятельности социальных институтов в регламентации ситуаций в делах помощи и поддержки, локализации трудных жизненных ситуаций через профессиональное сообщество социальных работников.

The problem of the formation of professional social work in Russia from the early 1990s to 2000 is studied. The changes associated with the processes of de-Sovietization of Russian society are analyzed; the dominant object of social services assistance is identified - an individual, categories of citizens for providing specific services and institutional support: refugees, street children, unemployed, children in difficult life situations, children left without parental care. The role of the state and the current legislation in the activities of social institutions in regulating situations in matters of assistance and support, localization of difficult life situations through the professional community of social workers is shown.
Experimental Study Comparing Release in Stretch Position, Myokinetic Releases, and MFR to Increase Muscle Extensibility
Authors: Upneja* Prakhar , Arora Maneesh , Wadhwa Meghna
Published: November 2022

Background Effective maintenance of the bodyrsquos flexibility offers better mobility allowing full range of motion and reduces the risk of injury from muscle restriction. Musclersquos fixation in shortened position causes a decrease in the number of sarcomeres. Since muscle is a mutable tissue the shortening is reversible. The treatment for this is stretching. Many studies concluded that there is no effective technique that individually stretches Tensor Fascia Latae TFL or pectoralis minor. Soft tissue manipulation techniques can be used to treat the shortening of these muscles. This study aimed to determine which among the three techniques i.e stretch position myokinetic active release and myofascial release was better to gain the optimal muscle length.Methods The study included 30 participants with tensor fascia latae tightness and 30 participants with pectoralis minor tightness. Pre-treatment length was tested and then the participants were split into three groups. Each group consisted of 10 participants with pectoralis minor muscle tightness and 10 participants with tensor fascia latae muscle tightness. For subjects in Group 1 Myokinetic active release therapy was given. For group 2 muscle release in stretched position was done and for group 3 the conventional myofascial release was given. After the treatment post-treatment length was tested. Pre-and post-treatment length was analyzed using paired t-test for within the group and ANOVA for between the groups.Results The results of the study proved that all the treatment techniques were effective on both the muscles. The results of all the groups showed a statistically significant value of lt0.05. But on comparing the groups the result was non-significant.Conclusion The results demonstrated that all the three techniques were equally effective.
Influence of Cleaning Solutions on Shear Bond Strength of Resin Cement to Saliva Contaminated Zirconia: an In-Vitro Study
Authors: Rashid Saba , M Reddy Subhash , Alva Harshitha , Shetty Jayakar
Published: November 2022

Background and Aim Zirconia is widely used as an aesthetic restorative material. Reliable bonding of zirconia ceramic is obtained by mechanical retention and chemical bonding of resin luting cement to ceramic substrate. Resin ceramic bonding is compromised in clinical settings when compared with clean lab settings. During try-in of restoration saliva contamination weakens the bond strength of zirconia to resin cement. The objective of this study was to investigate the effect of different cleaning solutions on the shear bond strength of resin cement to saliva-contaminated zirconia.Methods After saliva contamination zirconia disc specimens were cleaned with one of the four methods water rinsing Ivoclean 5 sodium hypochlorite and 1 hydrogen peroxide. Zirconia discs without saliva contamination were used as a control group. Resin cement cylinders were then built on zirconia discs using Rely X Unicem Automix resin cement. All specimens were stored at 37C in distilled water for 24 hours. The shear bond strength testing was performed by a universal testing machine. One-Way ANOVA test and Tukeyrsquos Post Hoc analysis were performed.Results Contaminated zirconia discs cleaned with Ivoclean and 5 sodium hypochlorite provided shear bond strength similar to the control group.Conclusion Ivoclean and 5 sodium hypochlorite were effective in cleaning the saliva-contaminated zirconia.nbsp
The Effect of Water Aging on Shear Bond Strength of Pretreated Zirconia-Oxide Ceramics Bonded to Resin Cement – An In Vitro Study
Authors: Aishwarya Gupta , Harshitha* Alva , Subash M , Jayakar Shetty
Published: November 2022

Background and Aim Use of zirconia oxide based ceramic system has become increasingly popular in dentistry because of zirconiarsquos esthetic and mechanical properties and its biocompatibility. Success of ceramic esthetic restoration depends on achievement of high retention and fracture resistance after cementation. Micro chemical retention can be achieved by various surface treatments. There are reports stating that long term presence of moisture decreases the physical properties of material and increases the risk of failure. Aging leads to changes in behaviour of material weakening it and subsequently degrading the material. This study investigated the phenomenon of aging of zirconia-resin by thermocycling in order to assess the problems related to its use and effect on shear bond strength of zirconia by bonding with cement.Method Twelve zirconia discs were taken and were divided into three groups having four discs each. Five resin cylinders were built on each disc. Group A was sandblasted which served as control group. Group B was exposed to hot etching using methanol 800 mL 37 HCl 200 mL and Ferric chloride 2 gm at 100 degC. Group C involved applying a layer of zirconia primer. After surface treatment two discs from each group were exposed to 500 thermocycling cycles simulating the oral environment. The shear bond strength testing was done following this. One way ANOVA test and Tukeyrsquos Post Hoc analysis were performed.Result Zirconia primer showed the maximum strength with and without exposure to thermocycling.Conclusion Zirconia primer proved to be a more effective surface treatment.nbsp
GPER1 links estrogens to centrosome amplification and chromosomal instability in human colon cells
Authors: Bühler Miriam , Fahrländer Jeanine , Sauter Alexander , Becker Markus , Wistorf Elisa , Steinfath Matthias , Stolz Ailine
Published: November 2022

The role of the alternate G protein–coupled estrogen receptor 1 (GPER1) in colorectal cancer (CRC) development and progression is unclear, not least because of conflicting clinical and experimental evidence for pro- and anti-tumorigenic activities. Here, we show that low concentrations of the estrogenic GPER1 ligands, 17β-estradiol, bisphenol A, and diethylstilbestrol cause the generation of lagging chromosomes in normal colon and CRC cell lines, which manifest in whole chromosomal instability and aneuploidy. Mechanistically, (xeno)estrogens triggered centrosome amplification by inducing centriole overduplication that leads to transient multipolar mitotic spindles, chromosome alignment defects, and mitotic laggards. Remarkably, we could demonstrate a significant role of estrogen-activated GPER1 in centrosome amplification and increased karyotype variability. Indeed, both gene-specific knockdown and inhibition of GPER1 effectively restored normal centrosome numbers and karyotype stability in cells exposed to 17β-estradiol, bisphenol A, or diethylstilbestrol. Thus, our results reveal a novel link between estrogen-activated GPER1 and the induction of key CRC-prone lesions, supporting a pivotal role of the alternate estrogen receptor in colon neoplastic transformation and tumor progression.
Radiogenic Isotope Studies of Late Cenozoic Volcanic Rocks from Asia and North America: Sources of Volcanism of Global, Regional, and Local Significance
Authors:   Institute of the Earth's Crust SB RAS, Chuvashova I.S. ,   Irkutsk State University, Rasskazov S.V. ,   Institute of the Earth's Crust SB RAS,   Irkutsk State University, Yasnygina T.A. ,   Institute of the Earth's Crust SB RAS, Saranina E.V. ,   Institute of the Earth's Crust SB RAS,   Institute of Geochemistry, Russian Academy of Sciences, A.P. Vinogradov SB RAS
Published: November 2022

Of global importance are sources of Late Cenozoic volcanic rocks, indicated by fast and slow anomalies of the lower mantle: ASITA, SOPITA, AFITA, and NAITA. ASITA characterizes the LOMU–ELMU protomantle melt anomalies of the lower mantle high velocity skeleton of Asia during the early mantle geodynamic epoch. SOPITA and AFITA are marked by the HIMU plume component, which was generated in the low-velocity lower mantle of the South Pacific and Africa during the middle mantle geodynamic epoch, about 2 Ga. NAITA denotes processes of generation of the North American high-velocity lower-mantle anomaly in the late geodynamic epoch. Of regional importance are sub-lithospheric sources that are characterized by a common geochemical structure of volcanic rocks of large volcanic regions, formed due to the evolution of homogeneous proto-mantle deep reservoirs. An example is sources of the Wulanhada-Hannuoba and Abaga-Dariganga volcanic regions, marking the spatial transition from the LOMU proto-mantle reservoir of the former to the ELMU one of the latter. Local sources of volcanoes are displayed in limited volumes of melts from the heterogeneous lithosphere. An example is sources of the Wudalianchi volcanic field, on which, at first, in the time interval of 2.5–0.8 Ma, the material of the Laoshantou and Gelaqiu sources with a common age of 1.88 Ga occurred, and then, during the spatial-temporal evolution of volcanism in the last 0.6 Ma, the material from these sources was mixed with a younger lithospheric material.
Semi Analytical Solution for Fuzzy Autonomous Differential Equations
Authors: Suhhiem Mazin H. , Khwayyit Raad I.
Published: November 2022

In this work, we have used fuzzy Adomian decomposition method to find the fuzzy semi analytical solution of the fuzzy autonomous differential equations with fuzzy initial conditions. This method allows for the solution of the fuzzy initial value problems to be calculated in the form of an infinite fuzzy series in which the fuzzy components can be easily calculated. The fuzzy series solutions that we have obtained are accurate solutions and very close to the fuzzy exact analytical solutions. Some numerical results have been given to illustrate the efficiency of the used  method.
Determination of the size of rock fragments using RVM, GPR, and MPMR
Authors: Thangavel Pradeep , Samui Pijush
Published: November 2022

For predicting the size of rock fragments during drilling and blasting operations, this article uses GPR, RVM, and MPMR. The current analysis makes use of a blast data set generated in a prior investigation. In this study, a portion of the blast data was utilized to train a model to determine the mean particle size arising from blast fragmentation for each of the similarity groups generated. The particle size was modeled as a function of seven different variables. The dataset contains information about the bench height and drilled burden ratio (H / B), spacing to burden ratio (S / B), burden to hole diameter ratio (B / D), stemming to burden ratio (T / B), powder factor (Pf ), modulus of elasticity (E), and in-situ block size (XB) are the input and output is X50. By comparing forecasts with actual mean particle size values and predictions based on one of the most widely used fragmentation estimation techniques in the blasted literature, the capacity of the generated models may be established. The statistical parameters, actual vs predicted curve, Taylor diagram, error bar, and developed discrepancy ratio are used to analysis the performance of models. A comparative study has been carried out between the developed RVM, GPR, and MPMR. The results show the developed models have the capability for prediction of X50. From these comparisons, the MPMR has the highest value with a high degree of precision and robustness in the size of rock fragments X50.
Health care delivery above the established level: obligatory medical insurance contract performance or to the patient
Authors: Akhohova A. V. , Eshtrekova S. G. , Eshtrekova A. M. , Tkhabisimova I. K. , Khadzugov A. B.
Published: November 2022

The imperfection of the normative legal acts regulating legal relations between participants and subjects of compulsory medical insurance inevitably leads to the impossibility or difficulties for the parties to fulfill their obligations to ensure the provision of medical assistance to insured persons under compulsory medical insurance programs. Medical organizations included in the unified register of medical organizations operating in the field of CHI are limited in exercising their powers to provide medical care to citizens under the state guarantees program in the event that the volume of medical services provided exceeds the planned services provided for in the CHI agreement. The "forced" provision of medical care "in excess of the volume", in the first place, is aimed at meeting the actual needs of patients in this service. And ignoring this circumstance by medical organizations contradicts the basic principles of protecting the health of citizens, namely, the priority of its provision in the field of health protection.

The inadmissibility of refusal to provide medical care and the revision of legal instruments for its provision in order to avoid a negative impact on patients, and on the performer represented by a medical organization, is the topic of this discussion.

Presentation by the contractor in the person of a medical organization for payment of medical services in excess of the distributed volume and (or) financial security established by the medical organization in accordance with the legislation on CHI should not be a reason for refusing to provide medical services at the time of the consumer's request and when planning treatment. At the same time, based on the results of examinations conducted by insurance medical organizations for monitoring the volume of medical care for identified cases of medical care in excess of the distributed volume established by the decision of the commission for the development of the territorial program, acts of medical and economic control were drawn up.

Non-payment by the insurance medical organizations of the subject of bills for the rendered medical services, motivated by the excess of the volumes and financial support established by the territorial CHI program, served as the basis for the medical organization to file a lawsuit.
PERUBAHAN BENTUK DAN SUSUNAN RUANG PADA ARSITEKTUR TRADISIONAL SUKU BATAK TOBA MELALUI PENDEKATAN TIPOLOGI (Studi Kasus: Desa Simanindo, Kabupaten Samosir, Sumatera Utara)
Authors: Dafrina Armelia , Fidyati Fidyati , Siska Deassy
Published: November 2022

Suku Batak Toba sudah mendiami daerah Sumatera Utara selama hampir puluhan tahun. Rumah Bolon merupakan rumah adat tradisional Suku Batak Toba, namun banyak bangunan tradisional yang telah mengalami transformasi atau perubahan bentuk akibat beberapa faktor seperti pengaruh kebudayaan asing yang masuk disertai dengan kemajuan teknologi dan modernisasi, sehingga masyarakat terpengaruh dan beralih dengan membangun rumah modern dengan proses membangun yang jauh lebih cepat dan mudah apabila dibandingkan dengan pembuatan rumah tradisional. Hal tersebutlah yang akan menjadi ancaman akan kelanjutan kehidupan arsitektur tradisional. Pendekatan tipologi digunakan untuk mengelompokkan elemen arsitektur yang dimiliki oleh rumah adat Suku Batak Toba dan untuk mengetahui perubahan yang terjadi. Pemilihan sampel menggunakan metode purposive sampling. Metode penelitian yang digunakan adalah metode kualitatif dengan pendekatan fenomenologi dengan pengumpulan data yang dilakukan dengan cara wawancara, dokumentasi dan observasi langsung serta menggunakan data sekunder dengan cara melihat referensi buku, jurnal dan artikel yang berkaitan dengan penelitian. Sesuai dengan permasalahan yang telah diteliti dari beberapa sampel bahwa perubahan yang lebih banyak terjadi adalah transformasi subtraktif dan transformasi adiktif.
Soluble Complement Receptor 1 Therapeutics
Authors: P. Hardy Matthew , Rowe Tony , Wymann Sandra
Published: November 2022

Human Complement Receptor 1 (CR1/CD35) is a potent negative regulator of the complement system. Its mechanism of action is through interaction with the complement activation fragments, C3b and C4b to mediate decay acceleration of the C3 and C5 convertase complexes as well as cleavage of both ligands into inactive fragments via cofactor activity. The result is inhibition of the classical, lectin, and alternative complement pathways. This article will focus on recombinant soluble forms of CR1 that have been generated as potential therapeutics for complement-mediated disorders. Specifically, we will review and contrast the in vitro and in vivo properties of: sCR1 (BRL55730/TP10/CDX-1135), the soluble full-length extracellular domain of human CR1; sCR1-sLex (TP20), a glyco-engineered version of sCR1 additionally targeted to activated endothelium; APT070 (Mirococept), a CR1 fragment conjugated to a myristoylated peptide to enhance tissue targeting; and CSL040, a soluble truncated version of the CR1 extracellular domain which exhibits altered potency and pharmacokinetic properties as compared to the parental molecule. The data obtained from studies on the effects of these CR1-based molecules in animal models of disease and their therapeutic applications will also be discussed.
Evaluasi Kinerja Keuangan Bank Muamalat Indonesia Menggunakan Metode RGEC dan IPI Periode 2016-2020
Authors: Yulianti Chika Dwirahma , Wahyuni Eka Sri , Hariyadi Rizky
Published: November 2022

This study aims to determine the financial performance of Bank Muamalat Indonesia (BMI) for the 2016-2020 period. The study used descriptive quantitative methods. Evaluation of the financial performance of Bank Muamalat Indonesia (BMI) is carried out using the REGC method and the Islamicity Performance Index method. The results of the assessment of the financial performance of Bank Muamalat Indonesia (BMI) using the REC (Risk Profile, Earnings, and Capital) method can be concluded that the performance of Bank Muamalat Indonesia (BMI) for the 2016-2020 period is in good condition. The results of the evaluation of sharia financial performance based on the Islamicity Performance Index show that the sharia performance of Bank Muamalat Indonesia (BMI) for the 2016-2020 period is in poor condition, but BMI is the first Islamic bank and is still a bank that has made efforts to implement sharia principles and its social obligations as an Islamic bank.
Pelatihan Penulisan Karya Tulis Ilmiah Bagi Guru Ponpes Haramain Narmada Menuju Jurnal Nasional Terakreditasi
Authors: Ramdani Agus , Jufri A. Wahab , Jamaluddin
Published: November 2022

Kemampuan menulis khususnya menulis artikel ilmiah berbasis penelitian menjadi bagian yang tidak bisa dipisahkan dari profesi keguruan. Menulis artikel untuk jurnal ilmiah merupakan salah satu persyaratan untuk kenaikan pangkat bagi guru. Namun faktanya banyak guru yang belum melakukan publikasi ilmiah atau belum mampu menulis artikel ilmiah berbasis penelitian. Dari hasil angket yang diberikan kepada responden, diperoleh data bahwa para guru belum memiliki pengetahuan yang cukup dan luas tentang penulisan artikel ilmiah berbasis penelitian untuk internasional bereputasi.Kegiatan pengabdian ini bertujuan untuk meningkatkan pemahaman dan melatih keterampilan menulis serta mensubmit artikel ilmiah pada jurnal nasional terakreditasi bagi para guru di Ponpes Haramain, Narmada. Kegiatan ini dilaksanakan dengan menggunakan metode workshop dan dilanjutkan dengan bimbingan secara online. Pada kegiatan workshop tatap muka, disampaikan materi mengenai definisi artikel dan jurnal ilmiah, mengapa guru wajib memiliki kemampuan untuk meneliti dan menulis artikel, tata tulis artikel ilmiah serta alasan penolakan artikel di jurnal. Hasil pelatihan menunjukkan peningkatan kemampuan peserta dalam memahami tata cara menulis artikel ilmiah ke jurnal Nasional. Ketercapaian inti terlihat dari antusiasme peserta yang sangat baik pada saat pelatihan dan akan ada artikel yang disubmit ke Jurnal Nasional Terakreditasi.
Acessibilidade em pontos de ônibus equipados com totens informativos que contém publicidade
Authors: Nizer Cleverton , Silva Frederico Fonseca da , Pacheco Pedro Antônio Bittencourt , Fernandes Alexandre Machado , Paula Anjor Mujica de
Published: November 2022

v
SALAS DE RECURSOS MULTIFUNCIONAIS E O ATENDIMENTO EDUCACIONAL ESPECIALIZADO
Authors: Lemos Evanice Brígida Cavalcanti , Lima Vania Aparecida Alcantara , Moreira Aurea Barbosa , Araújo Adriana de Oliveira Silva , Andrade Lúcio Costa de , Baracho Thayane Lopes Miranda , Targino Edêlma , Matos Abraão Danziger de , Milan Davi , Silva Ednéia Escaramuça Inácio e , Souza Maria Aparecida de , Santos Maria José dos , Vidal Emanuela Andrade , Costa Maise Aires de Araujo , Vieira Maria Pereira , Silva Victor Alves Aragão Santiago da , Silva Ana Paula Floresta da , Santiago Junior Robertino Mendes , Beleti Junior Carlos Roberto , Sousa Dalila Morais de , Guerra Míriam Martinez
Published: November 2022

O livro traz uma 8 (oito) experiências exitosas a partir do fazer pedagógico de diversos professores do Atendimento Educacional Especializado/AEE em Salas de Recursos multifuncionais.