bluuebunny/crossref_metadata_2025 huggingface dataset:
INITIAL PROFESSIONAL TRAINING OF WORKERS' AND PEASANTS' MILITIA OFFICERS OF THE RSFSR PROVINCES IN THE 1920S (BASED ON THE MATERIALS OF THE FAR EASTERN REGION)
Authors: Ornatskaya Tatyana A.
Published: February 2025

The education system of the police officers of the Far East evolved together with the all-Union state educational system. Its development was significantly influenced by the level of education of the population, as well as political and ideological factors.
Far Eastern departmental schools and courses until the end of the 1920s were focused on the elimination of general and professional illiteracy and low literacy of students, i.e., they were actually an initial vocational school.
Purpose: to study the specifics of initial vocational education of police officers of the Russian Far East in the 1920s.
Materials and methods. The main research method is historical and descriptive. The source base of the article was the materials of central and regional archives containing both normative legal documentation and office work documents. The corpus of secondary sources mainly reveals the state of the initial vocational education of police officers in the central part of the RSFSR during the period under study, which is due to the lack of research on the topic in the regional, Far Eastern, material.
Results. The study of the historical experience of the formation and development of professional education of police officers in the Russian Far East in the 1920s allows us to substantiate its significance for the modern educational space and highlight the directions of its use in the future.
With the establishment of the republican form of government in Russia, the transformation of the content of legal norms began, as well as the restructuring of the system of professional education of law enforcement officers that had developed in the Russian Empire. It was transformed in line with the gradually forming Soviet legal field, was built in accordance with the national, intradepartmental, scientific, pedagogical and educational trends developing in the country, but in the Far East it had its own unique features. The features were associated with the protracted period of the civil war, the low level of education among the population, the high level of crime, the weak commitment of society to revolutionary ideas. All this determined the protracted nature of the inclusion of Far Eastern educational institutions of initial vocational training of police officers in the all-Union system.
GLP-1 and SGLT2 Therapies in Type 2 Diabetes Mellitus. Cutting-Edge Approaches to Advancing Diabetes Care
Authors: Parfianowicz Agnieszka , Alicja Surma
Published: February 2025

Type 2 diabetes mellitus (T2DM) is a multifactorial disease characterized by insulin resistance, beta-cell dysfunction, and chronic hyperglycemia. Despite the availability of conventional therapies, significant unmet needs persist in achieving optimal glycemic control and reducing long-term complications. GLP-1 receptor agonists (GLP-1 RAs) and SGLT2 inhibitors represent two novel classes of antidiabetic agents that have transformed the therapeutic landscape. This paper explores their mechanisms of action, clinical benefits, and potential synergistic effects, emphasizing their impact on cardiovascular and renal outcomes. Challenges and future directions for these agents in personalized diabetes care are also discussed.
De la voluntad moral por empatizar
Authors: Seoane Pinilla Julio
Published: February 2025

El presente trabajo parte de dos asunciones. La primera es sentimentalista y
apuesta por reconocer el papel de los sentimientos dentro de nuestro universo moral,
pero no para poner guante de seda a la razón, sino reconociendo el idioma propio
de los mismos que, por ello, debemos aprender a hablar, reconocer su sintaxis, su
organización discursiva, etc. La segunda es que tales sentimientos se comunican por
medio de la empatía. El texto continúa desarrollando lo que implica la empatía, a
saber, (a) un esfuerzo moral por ser empático, lo que se propone como el imperativo
moral de la empatía, (b) entender como propio un daño ajeno y, por ello, tratar de
eliminarlo y, finalmente, (c) un afinamiento de la empatía que se hace con relatos,
cuentos, y, sobre todo ejemplos. Esto último se propone como el necesario trabajo
del moralista.
Dilemas de contención y apaciguamiento de Rusia: una reflexión desde la teoría cognitiva de las perspectivas
Authors: Pardo Sauvageot Eric
Published: February 2025

La invasión a gran escala que Rusia inició el 22 de febrero de 2022 sigue
encontrando su eco en el mundo académico, pues sin duda alguna representa el
ejemplo más destacable de dos lecturas contrapuestas. Dado el desequilibrio de
poder entre Kiev y Moscú a favor de este último, el inicio de la invasión confería
gran credibilidad a la tesis clásica de la disuasión, según la cual Rusia se estaría
aprovechando de la debilidad de un Occidente no dispuesto a defender a Ucrania.
Esta lectura está diametralmente opuesta a la interpretación según la cual Rusia
reaccionó ante lo que se percibía como una amenaza de Occidente. Así, este artículo
pretende recordar las vías de investigación que ofrece la teoría de las perspectivas
como base teórica para una lectura de la guerra alternativa a la clásica lógica de la
disuasión. Aunque tanto la lógica de la disuasión como la teoría de la perspectiva
ofrecen explicaciones racionales, esta última, que de hecho también da cabida a la
primera, parte de la percepción cambiante y totalmente subjetiva de los actores y de cómo estos pueden actuar de manera diferente dependiendo de si el statu quo
se percibe como positivo o negativo. Si fuera lo primero, un actor que persiguiese
mejoras sería fácilmente disuadido ya que prevalecería la tendencia a actuar con
aversión al riesgo. Por el contrario, el mismo actor que percibiese un empeoramiento
del statu quo tendería a asumir mayores riesgos para revertirlo. Como se mostrará
aquí, ambas explicaciones racionales pueden ofrecer una interpretación de las
decisiones de Rusia, ya sea como un actor decididamente en pos de una mejora de
su statu quo o como un preservador del statu quo que asume riesgos por evitar su
deterioro.
Queja y relato del emigrado a Indias a través del discurso epistolar novohispano: la carta del conquistador Diego de Colio
Authors: Puente González Marta
Published: February 2025

En el presente trabajo nos proponemos abordar el estudio de la identidad
discursiva y la expresión de la subjetividad en el contexto de la prosa epistolar
del siglo XVI. Concretamente, analizaremos la única carta de relación conocida
del conquistador Diego de Colio. Esta misiva se inserta en un corpus de
correspondencia entre emigrados a Indias y el monarca español en torno a la
primera mitad del quinientos. Desde un enfoque pragmadiscursivo, analizaremos
aspectos de la vida en los nuevos territorios y conflictos territoriales a través del
estudio de los actos de habla de la carta, la deixis y las estrategias modalizadoras
del discurso. El objetivo último es el de poder dar cuenta, a través del estudio del
intercambio epistolar, de la configuración del universo privado y social del sujeto
conquistador y migrante y los flujos de pensamiento que se establecieron entre el
nuevo mundo americano y la vieja patria en España.
Catharine Macaulay Graham: Comentarios Indiscretos sobre ciertas posiciones que pueden encontrarse en los Rudimentos Filosóficos del Señor Hobbes sobre el gobierno y la sociedad. 1767. -II- / Loose Remarks on certain positions to be found in Mr. Hobbes´s Philosophical Rudiments of government and society. 1767. -II-.
Authors: Hurtado Simó Ricardo
Published: February 2025

Entre la edición de los volúmenes tercero y cuarto de La Historia de Inglaterra,
la historiadora y filósofa Catharine Macaulay Graham publica, en 1767, un texto
breve que rechaza los argumentos a favor de la monarquía absoluta contenidos en
De Cive, promoviendo una forma democrática de gobierno basada en la igualdad
y la libertad. Pese a tener un tono burlesco e irrespetuoso hacia Hobbes, el escrito alcanza gran notoriedad y contribuye a convertir a la autora en una mujer influyente
y reconocida dentro de los círculos radicales franceses, ingleses y en el movimiento
por la independencia de las colonias de Norteamérica.
Montando el caballo de Troya: la campaña presidencial de 1946 en Colombia y el fin de la República Liberal
Authors: Remolina Schneider Juan Pablo
Published: February 2025

Montando el caballo de Troya ofrece al lector una reconstrucción detallada de la campaña presidencial de 1946 en Colombia, desde el golpe de Estado de Pasto en 1944 hasta el día de los comicios, el 5 de mayo de 1946. A partir de ese momento, finalizaron dieciséis años seguidos de presidentes liberales a cargo del Poder Ejecutivo y se signó el inicio del periodo conocido como la Restauración Conservadora (1946-1957). El libro parte de un análisis dialógico de la estrategia editorial utilizada por el periódico El Siglo, como órgano del conservatismo laureanista; El Liberal, como el principal diario del liberalismo lopista, y Jornada, como el más importante periódico del liberalismo gaitanista. Esta reconstrucción prestó especial atención a ilustraciones, fotografías y caricaturas, como elementos centrales dentro de las estrategias de campaña de cada uno de estos periódicos. Así mismo, emplea extensas citas, con el fin de reconstruir de manera detallada cómo los diferentes periódicos y protagonistas del proceso de campaña presidencial experimentaron e interpretaron el desarrollo de la contienda electoral en diferentes momentos.
Co-infection with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1)
Authors: Madaras Laszlo , Anvari Radean , Schuchardt-Peet Claudia , Hoskote Abhinav , Kashyap Rahul
Published: February 2025

Introduction: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and human coronavirus HKU1 (HCoV-HKU1) are two forms of human coronaviruses known to cause respiratory tract symptoms. A co-infection with both viruses is rare, particularly in the United States. Case description: An 85-year-old male presented to the Emergency Department with recurrent falls, diarrhoea and cough, and whose viral panel was positive for both SARS-COV-2 and HCoV-HKU1. The patient developed bacterial pneumonia and was treated with antibacterial agents and glucocorticoids. His past medical history of atrial fibrillation required careful monitoring and subsequent discontinuation of remdesivir, a medication known to cause adverse cardiovascular effects in COVID-19 patients. The length of stay was also prolonged due to delirium and deconditioning. Ultimately, the patient required an urgent ablation followed by the placement of a permanent pacemaker, and anticoagulation therapy was initiated before discharge. The patient had a favourable outcome given the rarity of this case. Discussion: COVID-19 patients co-infected with other human coronaviruses should be monitored for disease progression and superimposed bacterial infections. Providers should be cautious with the use of remdesivir in cases of co-infection and in severely ill COVID-19 patients who have a history of atrial fibrillation.
Oral and intestinal manifestations of giant cell arteritis
Authors: Pernet Mathieu , Moi Laura , Serra Fulvia , Garin Nicolas
Published: February 2025

Background: Giant cell arteritis (GCA) is the most common primary vasculitis in individuals over 50 years of age. GCA typically affects large- and medium-sized arteries and is classically associated with cranial manifestations of ischaemia, such as headaches (notably in the temporal region), jaw claudication and visual symptoms that can lead to blindness. Extracranial symptoms are less frequently reported and are related to involvement of the thoracic and abdominal aorta and its main branches. Classic diagnostic tools (such as temporal artery ultrasonography and temporal artery biopsy) can be negative in extracranial GCA. Case description: We report a difficult diagnosis of GCA in a 75-year-old woman who developed painful tongue ulcers that responded to prednisone treatment. However, a comprehensive diagnostic work-up did not lead to a certain diagnosis of GCA and corticosteroids were stopped after one month. A few months later, the patient suffered from mechanical ileus secondary to ischaemic stenosis of the small bowel. Pathological examination of the small bowel resection, and a second FDG-PET/CT, led to the diagnosis of extracranial GCA. Conclusions: We present a case of CGA which sequentially affected cranial and extracranial arteries and illustrate pitfalls in the diagnosis of this polymorph condition.
Tracheal perforation and subcutaneous emphysema secondary to pseudomembranous invasive Aspergillus tracheobronchitis successfully managed with endotracheal tube manipulation
Authors: Shiraishi Kazushige , Lo Takkin
Published: February 2025

Introduction: Aspergillus is a ubiquitous fungus causing various pulmonary diseases depending on the host’s immune status. Aspergillus tracheobronchitis, a rare form of invasive aspergillosis, primarily affects severely immunocompromised or critically ill patients. We present the first known case of Aspergillus tracheobronchitis complicated by tracheal perforation and subcutaneous emphysema successfully treated with conservative endotracheal tube manipulation. Case description: A 64-year-old male with type 2 diabetes mellitus presented with generalized weakness and abdominal discomfort, later diagnosed with a perforated cecum requiring right colectomy. His postoperative course in the intensive care unit was complicated by septic shock, acute kidney injury, and failed extubation due to airway compromise. Seven days after the failed extubation, he developed subcutaneous emphysema in the neck. Chest computed tomography scan showed neck, left chest wall, and mediastinal emphysema. Bronchoscopy identified a focal black necrotic lesion on the left proximal tracheal wall and multiple small mucosal ulcerations throughout the proximal to distal trachea. The endotracheal tube was advanced beyond proximal tracheal necrotic lesion. Subcutaneous emphysema reduced overnight, suggesting that the lesion was the source of the air leak. Bronchial washings confirmed Aspergillus fumigatus, establishing a diagnosis of invasive Aspergillus tracheobronchitis. Treatment with voriconazole prevented further expansion of emphysema, which gradually resolved. Conclusion: Subcutaneous emphysema in ventilated patients with tracheobronchitis is a rare and challenging complication. This case demonstrates successful management through endotracheal tube manipulation to tamponade the lesion, highlighting subcutaneous emphysema as a potential manifestation of Aspergillus tracheobronchitis and offering a minimally invasive treatment approach.
Effects of comprehensive physiotherapy on pain, functionality, strength and joint space in male members of the military with dynamic knee valgus: a randomised controlled trial
Authors: Shadmanfar Soraya , Shakibaee Abolfazl , Mohtashami Reza , Alishiri Gholamhosein , Raei Mehdi
Published: February 2025

Background/Aims

This study was designed to diagnose and treat dynamic knee valgus based on the movement system impairment classification.

Methods

A total of 80 men with dynamic knee valgus were randomly divided into experimental (n= 40, mean age: 20.07 years) and control groups (n=40, mean age: 20.22 years). The control group received knee- and hip-strengthening exercises, and the experimental group, in addition to strengthening exercises, received specific instructions in functional activities and posterior X-taping. Clinical outcomes, including pain intensity, physical function, strength of quadriceps, hip abductor and hip external rotator muscles, plus a sonographic parameter, consisting of patellar condylar distance, were measured before and after 6 weeks of intervention.

Results

Significant improvements in all variables were observed in the experimental group after the intervention when compared to the control group (P<0.05). In within-group comparison, a significant improvement in pain intensity and increased strength in three muscle groups were observed in both groups after treatment compared to before treatment (P<0.05). The patellar condylar distance and physical function demonstrated significant changes in the experimental group (P<0.05), but not in the control group (P>0.05).

Conclusions

Comprehensive physiotherapy could lead to further improvement of clinical outcomes and joint space in military individuals with dynamic knee valgus.

Implications for practice

This therapeutic programme may be an effective factor in reducing the incidence of knee overuse injuries.
Choosing the Right Battery Chemistry
Authors: McNally Owen
Published: February 2025

Specifying LTO battery cell chemistry can be vital to boosting performance when it comes to some mobile industrial robots.
Land of The Giants
Authors: Seco Alberto
Published: February 2025

THIS DECADE, COMBINE HARVESTERS HAVE BECOME SIGNIFICANTLY LARGER AND MORE POWERFUL – AND BACK IN 2016 THE AJURIA CONCEPT, DESIGNED BY ALBERTO SECO AND PUBLISHED IN THE PAGES OF IVT, PREDICTED THIS TREND. NOW SECO HAS RETURNED TO THE DESIGN TO UPDATE IT FOR A NEW ERA
A New View
Authors: Krämer Martín Andrés
Published: February 2025

A NEW ELECTRIC TRACTOR CONCEPT FROM AN ARGENTINIAN INDUSTRIAL DESIGN GRADUATE HAS A VARIETY OF INNOVATIVE FEATURES INCLUDING THREE POSSIBLE DIFFERENT CAB POSITIONS, COMPATIBILITY WITH A HUGE VARIETY OF ATTACHMENTS, AND BATTERY SWAPPING TO ELIMINATE DOWNTIME
Extreme Applications
Authors: Francis Trinity
Published: February 2025

TO REDUCE THE RISKS OF MOVING HOT SLAG, OEMs VOLVO CE AND LIEBHERR HAVE DEVELOPED STEEL-MILL WHEEL LOADERS SPECIALLY ADAPTED FOR THE TASK – AND IN THE PROCESS CREATED THE SAFEST MOST DURABLE VEHICLES IN THEIR CLASS
Minimum Swing Maximum Power
Authors: Sooknanan Anjali
Published: February 2025

IT MAY BE A COMPACT MACHINE, BUT THE NEW 145XR REDUCED TAILSWING EXCAVATOR FROM JCB DOES NOT COMPROMISE ON POWER, COMFORT OR OPERATIONAL EFFICIENCY
Wind Tunnel Evaluation of Spray Nozzle and Droplet Size Effects on Spray Penetration Inside Soybean Plants
Authors: Castilho Theodoro Jose G. , Ozkan Erdal , Zhu Heping , Jeon Hongyoung , Campos Javier , Womac Alvin R.
Published: February 2025

Highlights

Effectiveness of four nozzle types was evaluated to deliver spray droplets inside soybean canopy in a wind tunnel.

Spray deposition at the bottom part of canopies was significantly lower than the upper part across the test section.

Nozzles generating medium and coarse droplet sizes improved spray coverage on the top and middle part of the canopy.

Abstract. Adequate spray deposition and penetration of pesticides reaching the lower part of soybean canopy can increase the chance of success to protect plants from diseases and insects, especially when soybean foliage is matured. Therefore, selecting the nozzle type with the most appropriate droplet size plays a significant role in providing the right amount of spray deposition to the right place in plant canopy. The objective of this study was to evaluate the most effective spray nozzle and droplet size distribution to achieve more spray coverage within the soybean canopy under a 2 ms-1 wind-tunnel-controlled wind speed at 0.38 m row spacing. An open circuit wind tunnel with laminar airflow was used to avoid the uncontrollable outdoor weather conditions that often vary when similar experiments are conducted in the field. Four commercial spray nozzles (droplet size): XR11004 (medium), TTJ6011004 (coarse), AITTJ6011004 (very coarse), and AI11004 (extremely coarse) were operated at 275 kPa pressure and sprayed for 3 s to increase the spray droplet density to detect their effects in the soybean canopy. Eleven pots of soybean plants were placed in the wind tunnel test section in three rows along the direction of airflow to simulate the 0.38 m soybean row spacing. For each test run, water sensitive papers (WSP) were placed at three different heights of the soybean canopy (top, middle, and bottom) within 5 soybean plants located 0.15, 0.70, 1.25, 1.80, and 2.40 m downwind from the spray boom. After plants were sprayed, WSP samples were collected to determine the spray coverage. The top of the canopy received the greatest amount of spray coverage, followed by the middle position. Regardless of the nozzle and droplet size, significantly lower amounts of spray deposition were found at the bottom part of the canopy at all the sample collection points along the wind tunnel test section. Overall, the nozzles that generated medium and coarse droplet sizes provided higher levels of spray coverage on the top and middle part of the soybean canopy. Providing adequate coverage in the bottom part of the canopy remained a challenge, which must be addressed in future studies to evaluate additional nozzle types with different droplet size classes under different wind speed and row spacing settings. Keywords: Droplet size spectrum, Nozzle type, Soybean plants, Spray coverage, Spray deposition.
Integrated InP-based transmitter for continuous-variable quantum key distribution
Authors: Aldama J. , Sarmiento S. , Trigo Vidarte L. , Etcheverry S. , López Grande I. , Castelvero L. , Hinojosa A. , Beckerwerth T. , Piétri Y. , Rhouni A. , Diamanti E. , Pruneri V.
Published: February 2025

Developing quantum key distribution (QKD) systems using monolithic photonic integrated circuits (PICs) can accelerate their adoption by a wide range of markets, thanks to the potential reduction in size, complexity of the overall system, power consumption, and production cost. In this work, we design, fabricate and characterize an InP-based PIC transmitter for continuous-variable (CV) QKD applications. In a proof-of-principle experiment implementing a pulsed Gaussian-modulated coherent state (GMCS) CV-QKD protocol over an optical fiber channel of 11 km, the system showed a performance compatible with a secret key rate of 78 kbps in the asymptotic regime. These results show the potential of InP technologies to integrate CV-QKD systems onto a monolithic platform.
Variable-focus flexible cylindrical lens based on near-infrared light-driven liquid crystal elastomers
Authors: Liu Shinian , Zhang Dawei , Wang Fei , Han Sancan , Yu Dechao , Li Fengting
Published: February 2025

This study explores a flexible cylindrical lens driven by near-infrared (NIR) light at 1200 mW and 808 nm. The design combines liquid-crystal elastomers (LCEs), as the driving component, with a highly transparent, deformable, and stable PDMS-based flexible cylindrical lens. The aim is to achieve a wide variable-focus range and high-quality focusing through light-driven methods. The initial structure of the flexible cylindrical lens was designed through theoretical calculations and simulation modeling. The lens itself was fabricated via thermoforming by mold injection PDMS, yielding an initial structure with an aperture diameter 2D′ = 16 mm, thickness d = 1 mm, and width h = 4 mm. Under a single-sided stretch of 3 mm, the variable-focus distance reached 51.3 mm. The imaging system, based on the flexible cylindrical lens, achieved a variable-focus distance of 31.2 mm within a single-sided stretch range of 2 mm, maintaining an MTF0.5 greater than 57.61 lp/mm, demonstrating high contrast and resolution. With the integration of LCEs as the driving component, a non-contact, NIR-light-driven variable-focus range of 10.35 mm was achieved within 25 s. This work highlights the application of NIR-light-driven LCEs within a variable-focus flexible cylindrical lens, providing new ideas and technical support for the development of future optical variable-focus devices.
Demonstration of enhanced Raman scattering in high-Q silicon nanocavities operating below the silicon band-gap wavelength
Authors: Takahashi Yasushi , Shimomura Yu , Ishihara Ayumi , Asano Takashi , Noda Susumu
Published: February 2025

We experimentally determined the quality factor (Q) and the intensity of the Raman scattered light for different silicon photonic-crystal nanocavities operating at wavelengths shorter than the silicon band-gap wavelength. Despite the relatively large absorption of silicon in this wavelength region, we observed Q values greater than 10,000 for cavities with a resonance wavelength of 1.05 µm, and Q values greater than 30,000 for cavities with a resonance wavelength of 1.10 µm. Additionally, we measured the Raman scattering spectra of cavities with resonance wavelengths of 1.10 µm and 1.21 µm. On average, the generation efficiency of the Raman scattered light in a 1.10-µm nanocavity is 6.5 times higher than that in a 1.21-µm nanocavity. These findings suggest that silicon nanocavities operating below the silicon band-gap wavelength could be useful in the development of silicon-based light sources.
SurfMon: a learning-based optical in-process surface monitoring system
Authors: Liu Samuel , Zhang Shaojian , Liu Kexin , Hon Bernard
Published: February 2025

Metrology is the key to ensuring the quality of manufactured parts. With the fast development in the manufacturing sector, particularly with the sustainable manufacturing requirement, there is a significant demand for manufacturing metrology to ensure not only the accuracy of the final parts but also the quality of the whole manufacturing process. As such, defects in the manufacturing process can be identified as early as possible and can potentially lead to saving of materials, energy, and cost and contribute to sustainability. In this paper, we present SurfMon, an in-process optical surface monitoring system that is portable and powered by laser speckle pattern measurements and a machine learning algorithm, making it highly flexible and able to learn from normal surfaces and detect anomalies in manufacturing processes. SurfMon essentially consists of a laser, a camera, a microcontroller with wireless connection functionality, and some optics. It is battery-powered and rechargeable, making it hassle-free to integrate into manufacturing facilities. Reflective laser speckle patterns from manufactured surfaces are captured, and a principal component analysis model is trained and used to detect defects. The system can be mounted on a machine tool and in-process surface measurements can be performed following the cutting tool. Anomalies are detected whenever they affect the surface topographies. The effectiveness of SurfMon was demonstrated on a CNC machine, and the results showed that SurfMon was promising for in-process surface monitoring in manufacturing processes.
Interpreting the CTCF-mediated sequence grammar of genome folding with AkitaV2
Authors: Smaruj Paulina N. , Kamulegeya Fahad , Kelley David R. , Fudenberg Geoffrey
Published: February 2025

Interphase mammalian genomes are folded in 3D with complex locus-specific patterns that impact gene regulation. CTCF (CCCTC-binding factor) is a key architectural protein that binds specific DNA sites, halts cohesin-mediated loop extrusion, and enables long-range chromatin interactions. There are hundreds of thousands of annotated CTCF-binding sites in mammalian genomes; disruptions of some result in distinct phenotypes, while others have no visible effect. Despite their importance, the determinants of which CTCF sites are necessary for genome folding and gene regulation remain unclear. Here, we update and utilize Akita, a convolutional neural network model, to extract the sequence preferences and grammar of CTCF contributing to genome folding. Our analyses of individual CTCF sites reveal four predictions: (i) only a small fraction of genomic sites are impactful; (ii) impact is highly dependent on sequences flanking the core CTCF binding motif; (iii) core and flanking nucleotides contribute largely additively to the overall impact of a site; (iv) sites created as combinations of different core and flanking sequences have impacts proportional to the product of their average impacts, i.e. they are broadly compatible. Our analysis of collections of CTCF sites make two predictions for multi-motif grammar: (i) insulation strength depends on the number of CTCF sites within a cluster, and (ii) pattern formation is governed by the orientation and spacing of these sites, rather than any inherent specialization of the CTCF motifs themselves. In sum, we present a framework for using neural network models to probe the sequences instructing genome folding and provide a number of predictions to guide future experimental inquiries.
Socioeconomic disparities in depression risk: Limitations of the moderate effect of physical activity changes in Korea
Authors: Lee Su Kyoung , Kwon Yong Jin
Published: February 2025

This study investigates the influence of changes in physical activity (PA) patterns on depression risk across different socioeconomic statuses (SES) in Korea. Utilizing National Health Insurance Data (NHID) from over 1.2 million individuals during 2013–2016, we matched medical aid beneficiaries with health insurance beneficiaries, excluding those with prior depression or incomplete PA data. Changes in moderate-to-vigorous PA (MVPA) were categorized into 16 groups, and depression incidence was tracked from 2019 to 2021. After adjustment, medical aid beneficiaries consistently showed higher risks of depression compared to health insurance enrollees with the same physical activity (PA) change patterns. For those consistently inactive, the risk was 1.68 times higher (aOR, 1.68; 95% CI, 1.37–2.05). Those who increased PA from inactivity to moderate-to-vigorous activity 3–4 times per week had a 3.33 times higher risk (aOR, 3.33; 95% CI, 1.72–6.43). Additionally, the risk was 2.64 times higher for those increasing from 1–2 times to ≥5 times per week (aOR, 2.64; 95% CI, 1.35–5.15), and 2.83 times higher for those consistently engaging in PA 3–4 times per week (aOR, 2.83; 95% CI, 1.35–5.94). Across the overall PA patterns, medical aid beneficiaries consistently faced higher depression risks, with risk increases of 1.80 times for increased activity, 1.68 times for continuous inactivity, and 1.34 times for decreased activity compared to health insurance beneficiaries with the same PA change patterns. However, in the consistently very active group, no significant difference in the risk of depression was observed between the two groups. Limitations include potential bias in self-reported PA and the NHIS data not fully capturing depression severity. The findings underscore the significant impact of SES on mental health, with consistently high PA levels potentially mitigating SES-related depression risk.
Accessibility without a compass: Transdisciplinary choreographies beyond the habitus of visual perception
Authors: Richmond Aaron
Published: February 2025

This article explores how transdisciplinarity might offer a helpful conceptual framework for taking seriously how artistic curiosities and desires converge around questions of access. My suggestion is that artists working at the borderlines of disability justice do so not only in the interest of a more inclusive, just society – but also to rediscover their working processes in new and unfamiliar configurations and collaborations. In making this point, I pursue what Natalie Loveless calls the ‘polydisciplinamory’ nature of contemporary research-creation – i.e., an eros-driven curiosity about how things are made, and a renewed care for the specificities of their sensuous form.
Fade to black and other notes on becoming
Authors: DeFazio Paul
Published: February 2025

This article explores ‘becoming blind’ as a complex process that extends beyond vision loss to encompass cultural, emotional and creative dimensions. Drawing on disability studies by scholars like Georgina Kleege and Alison Kafer, it examines how blindness has influenced the author’s work in vision-centric fields like art and design, challenging conventional narratives that frame blindness solely as a form of loss. Instead, the article presents blindness as a source of curiosity, invention and aesthetic richness, engaging with themes such as the cultural fear of darkness, the creative potential in ‘breaking’ visual norms like sharpness and clarity, and the tactile ways of experiencing space and contour. It reflects on how blindness reshapes identity, artistic practice and understandings of disability within able-bodied frameworks. Ultimately, the article advocates for expanding art and design practices to include disabled and blind perspectives, valuing blindness as a generative, transformative way of engaging with the world.
What is your disposition, language, house? ‘Fruitful asynchrony’ and the maker-thinker
Authors: Hendren Sara
Published: February 2025

Psychology and cognition scholar Howard Gardner’s concept of ‘fruitful asynchrony’ provides the foundation for the author to understand her own interdisciplinary work between critical design, engineering and disability studies. The author introduces her own framework of ‘disposition, language, house’ as a further heuristic to understand the interdisciplinary nature of design theory and practice.
Writing the experience of the Grand Union Canal in Harlesden as an intersensorial spatial practice
Authors: Rowlands Elinor
Published: February 2025

This essay is written as a discursive experimental expression of the autistic and artistic perspective of making ‘Biodivergent Sites & Sounds’ (BSS). This is an autoethnographic fictional investigation of place, of waterways and of autism as a cultural identity. BSS is an immersive and accessible online experience of the Grand Union Canal (London). BSS was led by transdisciplinary artist and researcher Elinor Rowlands in collaboration with neurodivergent artists and the Canal & River Trust. Most collaborating artists are autistic. This is important to the transdisciplinarity modes and realization of making, thinking and being in this project that this essay explores. A specific new glossary of language emerged through this project that is now being used by the collaborating artists towards leading their own funded arts projects. This new vocabulary articulates modes of practice-based processes realized through making BSS that has the potential to contribute to wider contexts and articulation of creative practices.
Cripping transdisciplinarity
Authors: King Andrew David
Published: February 2025

This article argues for the mutual relevance of disabled and crip critique to theories of transdisciplinarity in the context of questions about multimodal aesthetics and accessibility. Recapitulating the author’s preliminary search, using the methods of analytic philosophy, for answers to these questions, the essay turns to the notion of ‘cripping’ – interrogating received categories of the normative and non-normative using the tools of disability-based critique – to imagine how, through a cripped version of transdisciplinarity, new practical and theoretical possibilities for imagining access in the arts might emerge.
‘Stories of Access’: Tangled Art + Disability and cultural accessibility in action
Authors: Chandler Eliza , Johnson Megan A.
Published: February 2025

In this article we engage a transdisciplinary perspective to analyse cultural accessibility practices, which are access practices developed by disabled people for the cultural field. Cultural accessibility seeks to disrupt normative culture by creating flexible practices that centre disabled people and disability community. Drawing on research with Tangled Art + Disability, a disability art gallery in Toronto, Canada, we explore the iterative and collaborative processes through which the organization has developed cultural accessibility practices. We narrate the provenance of these practices through ‘Stories of Access’ that illustrate how the context of the gallery – including artists, staff, audiences, resources, technologies, materials, spaces, policies and access commitments – influenced their development. Throughout, we demonstrate how thinking about practices of cultural accessibility as themselves transdisciplinary allows us to track more nuanced origin stories as embedded in institutional history, crip wisdom and practices and organizational specificity and resist the ways that access is taken up as a non-relational practice.
Editorial: ‘Transdisciplinarity in Disability, Art and Design’
Authors: Cachia Amanda , Shercliff Emma , Speight Elaine
Published: February 2025

This Special Issue, guest-edited by art historian and curator Amanda Cachia, brings together artists and researchers situated in the overlapping communities concerned with disability studies, art and design to explore how the concept of ‘transdisciplinarity’ helps to navigate the intersection of disability, art form, audience and context. Readers will encounter a dynamic blend of twelve scholarly and artistic projects, which collectively explore evolutions and trends within the cross-pollination of disability, art and design, and explore the critical role of access as a medium of change.
A nemkívánatos mértékű turizmus hatása a helyi lakosság jóllétére Budapest VII. kerületében
Authors:   , Molnár-Csomós Ilona Erzsébet
Published: February 2025

A nemkívánatos mértékű turizmus okozta problematikus helyzet feloldása – ami az éjszakai gazdaság (Night-Time Economy, NTE) térnyeréséből (Pinke-Sziva et al. 2019a, Olt et al. 2019) is eredeztethető – mind Budapest legkisebb alapterületű kerületében, mind pedig fővárosi szinten relevanciával bír, melynek időszerűsége a pandémiás hatások mérséklését követően ismét megkérdőjelezhetetlenné vált. Turistaként szívesebben utazunk olyan helyre, ahol a helyiek is jó közérzettel bírnak, emiatt a lakosság jóllét-érzete jelentős mértékben befolyásolja egy hely turizmusának sikerét (Michalkó – Rátz 2006). A szerzők (Michalkó – Rátz 2006) által alkotott miliő elmélet felhívja a figyelmet a helyiek közérzetéből fakadó életvidám és nyílt hozzáállás sajátos vonzerőként való értelmezésének fontosságára. Mindennek okán egyre inkább nyilvánvalóvá válik, hogy a helyi lakosság a turistákkal egyenrangú szereppel bír. A turizmus a látogatókról és a helyiekről egyaránt szól (Kiss et al. 2020), komplex kapcsolatrendszerként értelmezhető. Amennyiben pedig egy kapcsolatrendszer komplexitását tekintve összetettnek minősül, úgy az egyént kell a vizsgálódások fókuszába helyezni (Simon – Lantos 2016).
CLIMATE CHANGE IMPACT ANALYSIS USING BIG DATA
Authors: Ogunmodede Peace , Adebo Zecharias , Getachow Gemechu , Dabisa Ruth , Mengistu Tarekegn , Telila Lemlem , L. Diadula Adrian , Maduka Egbuka Martin , Abdulazeez Adekunle Abioye , Dike Monalisa , Bilau Dauda
Published: February 2025

This report captures the transformative journey of conceptualizing and implementing the Climate Change Impact Analysis Tool within the framework of Osiri University's Technology and Venture Creation (TVC) course. Designed to address critical challenges posed by climate change in sub-Saharan Africa, this venture integrates advanced technologies such as big data, artificial intelligence (AI), and Internet of Things (IoT). The tool provides actionable, real-time insights to enhance climate resilience for governments, NGOs, and local communities in vulnerable regions like Ethiopia, Nigeria, and South Africa. The course exemplified the fusion of entrepreneurship theory and practical application, particularly in fostering technological solutions for societal challenges. Through experiential learning methodologies, the TVC program encouraged innovation, critical thinking, and entrepreneurial leadership. A hallmark of the project was the integration of the Ubuntu philosophy, which underscores community, trust, and shared responsibility. This ethos shaped the venture's collaborative team dynamics and ethical approach, ensuring that the tool’s deployment prioritized inclusivity and social equity.

The venture creation process was not without challenges, including technical complexities in integrating diverse data sources and navigating market segmentation across varied socioeconomic contexts. These obstacles were overcome through methodologies like Lean Startup and Design Thinking, which facilitated iterative development and stakeholder engagement. The result was a robust, scalable product tailored to local needs. This experience underscored key insights: the importance of aligning technology with ethical considerations, leveraging collective leadership inspired by Ubuntu, and focusing on long-term relationships with stakeholders. These principles were instrumental in addressing not only immediate climate-related issues but also broader goals of sustainable development and economic empowerment.

In conclusion, the Climate Change Impact Analysis Tool represents a paradigm shift in how technology can drive social impact. Grounded in the principles of Ubuntu and guided by the TVC course, this venture serves as a model for integrating innovation with ethical entrepreneurship to tackle global challenges.
PROBIOTICS PRESCRIBED WITH HELICOBACTER PYLORI ERADICATION THERAPY IN EUROPE: USAGE PATTERN, EFFECTIVENESS, AND SAFETY: Results from the European Registry on Helicobacter pylori Management (Hp-EuReg)
Authors: Deza Diego Casas , Alcedo Javier , Lafuente Miguel , López F. Javier , Perez-Aisa Ángeles , Pavoni Matteo , Tepes Bojan , Jonaitis Laimas , Castro-Fernandez Manuel , Pabón-Carrasco Manuel , Keco-Huerga Alma , Voynovan Irina , Bujanda Luis , Lucendo Alfredo J. , Jurecic Natasa Brglez , Denkovski Maja , Vologzanina Ludmila , Rodrigo Luis , Martínez-Domínguez Samuel J. , Fadieienko Galyna , Huguet Jose M. , Abdulkhakov Rustam , Abdulkhakov Sayar R. , Alcaide Noelia , Velayos Benito , Hernández Luis , Bordin Dmitry S. , Gasbarrini Antonio , Kupcinskas Juozas , Babayeva Gülüstan , Gridnyev Oleksiy , Leja Mārcis , Rokkas Theodore , Marcos-Pinto Ricardo , Lerang Frode , Boltin Doron , Mestrovic Antonio , Smith Sinead M. , Venerito Marino , Boyanova Lyudmila , Milivojevic Vladimir , Doulberis Michael , Kunovsky Lumir , Parra Pablo , Cano-Català Anna , Moreira Leticia , Nyssen Olga P. , Megraud Francis , Morain Colm O , Gisbert Javier P. ,   on behalf of the Hp-EuReg investigators
Published: February 2025

Aim:

To evaluate the prescriptions patterns, effectiveness, and safety of adding probiotics to Helicobacter pylori eradication therapy, in Europe.

Design:

International, prospective, non-interventional registry of the clinical practice of the European gastroenterologists. Data were collected and quality reviewed until March 2021 at AEG-REDCap. The effectiveness was evaluated by modified intention-to-treat analysis, differentiating by geographic areas. Adverse events (AE) were categorized as mild, moderate, and severe.

Results:

Overall, 36,699 treatments were recorded, where 8,233 (22%) were prescribed with probiotics. Probiotics use was associated with higher effectiveness in the overall analysis (OR 1.631 [95% CI 1.456-1.828]), as well as in triple (1.702 [1.403-2.065]), quadruple (1.383 [0.996-1.920]), bismuth quadruple (1.248 [1.003-1.554] and sequential therapies (3.690 [2.686-5.069]). Lactobacillus genus was associated with a higher therapy effectiveness in Eastern Europe when triple (OR: 2.625 [CI 1.911, 3.606]) and bismuth quadruple (OR: 1.587 [CI 1.117, 2.254]) first-line therapies were prescribed. In Central Europe, the use of probiotics was associated with a decrease in both the overall incidence of AEs (0.656 [0.516, 0.888]) as well as severe AEs (0.312; [0.217, 0.449]). Bifidobacterium genus was associated with lower overall (OR: 0.725 [95% CI 0.592-0.888]) and severe (OR: 0.254 [0.185-0.347]) AEs; and Saccharomyces was associated with reduced overall (OR: 0.54 [CI 0.32-0.91]) and severe (OR 0.257 [CI 0.123-0.536]) AEs under quadruple-bismuth regimen.

Conclusions:

In Europe, the use of probiotics was associated with higher effectiveness and safety of H. pylori eradication therapy. Lactobacillus improved treatment effectiveness, while Bifidobacterium and Saccharomyces were associated with a better safety profile.
A review on way towards mechanized castor cultivation
Authors: Gowsalya R , Natarajan S K , Ragavan T , Venkatachalam S R , Thambidurai S
Published: February 2025

Castor (Ricinus communis L.) is an important non edible oil seed crop which is known for its oil content (48–60 percent) and it accounts for 0.15% of the global production of vegetable oil. In recent years, farmers have preferred castor cultivation due to its suitability for both rainfed and irrigated conditions. But the farmers face many challenges, which includes labour scarcity, pest incidence, high input and labour costs, inadequate market information, etc. Due to a significant labour shortage, the area under this crop is gradually decreasing. The high reliance on human labour which leads to the incompletion of various agronomic operations on time. In these circumstances, the cultivation of castor by adopting various mechanization techniques for critical operations such as field preparation, sowing, fertilizer application, weeding, irrigation, crop protection measures and harvesting will be the solution for getting higher productivity and profitability by spending minimum expenses. Adapting mechanization is crucial for achieving sustainable development goals by enhancing production through timely farm operations, minimizing losses and reducing operational costs through efficient management of expensive inputs.
Natural Becoming: From Bad Infinity Towards an Open Dialectic? Contemporary Issues Moving From Hegel’s Philosophy of Nature
Authors: Erle Giorgio
Published: February 2025

In Hegel’s Philosophy, natural time is the engine of bad infinity, presenting itself through disappearance. Nevertheless, as one proceeds towards the higher levels of the realm of exteriority, this force from abstract becomes increasingly real until it becomes part of vital processes in the organized subjectivity, such as that of the living organism that “knows” and uses this becoming as a force to its advantage, e.g., in the forms of metabolism. This effective meaning of natural becoming seems to us to have been particularly highlighted in the 20th–century in the “Philosophical Biology” of Hans Jonas, whereby even the elements of failure (e.g., in the animal’s procurement of food) are grasped as expressions of a distinctive trait of the subject, namely its capacity to bear the negative and with this to establish mediation.Even the mortal limit, which is what leads to the conclusion of the Naturphilosophie requiring the elevation to the Philosophy of Spirit in Hegel, according to Jonas, takes on, within the human awareness, a renewed ontological value that allows life to flourish again and with this makes human beings able to ask themselves what kind of world they want to hand over (also with environmental regard) to future generations. If this is the case, then a role for Naturphilosophie becomes highly topical about producing an “open dialectic” invoked many times in the philosophical paths of the 20th century.
Ameliorative effects of avocado oil on bleomycin‐induced lung fibrosis and oxidative stress in rats
Authors: Ochi Naoures , Abidi Anouar , Taamalli Wael , Ayedi Ayda , Sebai Hichem
Published: February 2025

Pulmonary fibrosis (PF), is a chronic interstitial lung disease, characterized by changes in the alveoli, excessive accumulation of extracellular matrix, persistent inflammation, and oxidative stress. In this study, we aimed to explore the therapeutic effects of avocado oil (Ao) on bleomycin (BLM)‐induced PF. Four this, 24 male rats were divided into four groups (n = 6): the first group served as a control, the second served as a fibrotic group, instilled intratracheally only with BLM (2 mg/kg bw), and the remaining groups were treated by gastric gavage with Ao at different doses (3.5 and 5 mL/kg bw) for 25 days after BLM instillation. The fibrosis induction revealed significant alterations, including increased lipid peroxidation and decreased antioxidant enzyme activities such as superoxyde dismutase (SOD) and catalase (CAT), level of thiols group coupled with a high fibrosis score (FS) and an inflammatory index (II), along with excessive collagen deposition in the pulmonary interstitium. Ao treatment reversed all disturbances induced by BLM in oxidative stress parameters and relatively repairs the histological damage caused by BLM by reducing the FS and the II. The antioxidant, anti‐inflammatory and anti‐fibrosis power of Ao, may suggest this last as a promising candidate for the treatment of PF.