bluuebunny/crossref_metadata_2025 huggingface dataset:
Exosomes potential therapeutics
Authors: Dowaidar Moataz
Published: June 2021

Finding novel drug delivery techniques and enhancing current ones for better pharmacokinetics and enhanced transportation capacity through the central nervous system (CNS) is a key research topic. When proteins, nucleic acids and other macromolecules are used as CNS treatments, crossing the blood-brain barrier (BBB) is a challenge. Due to poor targeting, release of kinetics and failure to achieve brain therapeutic concentrations, the BBB restricts the predicted therapeutic effects on the CNS. As a result, following systemic administration, most potentially useful diagnostic and therapeutic medicines can not reach the brain. Many invasive procedures such as neurosurgery and BBB osmotic/biochemical opening are used to deliver medicine to the brain, suggesting a loss in drug efficacy and increased patient risks. Translating novel neurotherapeutics from the bench to the bedside will be hard unless we find a mechanism for delivering drugs that can successfully cross the BBB. Extracellular vesicles (EVs) or nanovesicles are now generally known to have a function in intercellular communication in both normal and pathological circumstances, including HIV infection. With EVs and HIV, researchers face many hurdles. Because of comparable structural and molecular features, investigations requiring separation of EVs and HIV may generate problems. currently investigating pathogenic pathways of viral protein-mediated neurotoxicity involving EVs. Furthermore, developing effective pharmacological amelioration strategies to counteract the harmful effects of HIV and eliminating HIV reservoirs is important, especially in people with HAND. As nanotechnology advances, many nanocarriers are being explored as a way of delivering medicines to the CNS. Exosomes show potential as drug delivery vehicles. Exosomes have an advantage in terms of potential because of their inherent ability to encapsulate biological and chemical compounds, the ease with which surface modification can be accomplished, and their endogenous nature. However, additional investigation is needed to overcome the challenges discovered in EV research before considering EVs as a feasible way of delivering medicines. Future investigations might focus on EV research concerns such as improved EV separation, loading, characterization, quantification, and in vivo tracking approaches.
MSMEs and Digital Platforms During Covid-19
Authors: kartikaputri arella
Published: June 2021

In this covid-19 pandemic situation, a new business platform is a must for companies that disrupt new media technology. However, many incumbent companies are less able to keep up with changing business trends. This is very unfortunate, because companies must anticipate all changes in the competitive climate in this digital era both in carrying out corporate transformation programs to avoid verbal dangers and a greater risk of failure.
Biogenic particles can be multiantigenic, immunostimulative and activate innate immunity while suppressing tumor development
Authors: Dowaidar Moataz
Published: June 2021

Cancer immunotherapy, which attempts to activate or stimulate the immune system to treat cancer, has become the standard of treatment. Although some cancer vaccines are efficiently translated, they have not yet reached the same degree of success as infectious disease immunizations. A primary factor is the low immunogenicity of the tumor and related antigens. Unlike viruses, cancer cells emerge from somatic mutations in patients' healthy tissues, making it harder for the immune system to properly detect tumor cells. Biogenic nanoparticles have recently been highlighted as a solution to address some of the issues with creating anticancer vaccinations. Antigens, medication delivery, and others all benefit from biogenic nanoparticles. Biogenic nanoparticles have long been researched as a vaccine. Biogenic nanoparticles-based platforms, like particular VLPs, inherently activate inflammatory responses and may be increased with TAAs evaluated for antigen-specific antitumor responses to patient malignancies. OMVs and OMV-coated nanoparticles can be multiantigenic and immunostimulative in the box. PAMPs present in OMVs can activate innate immunity while suppressing tumor development. A range of cells, including immune and malignant cells, produce exosomes and play a critical role in cell-to-cell communication. Exosomes may contain interesting materials such as specific drugs, proteins, DNA, and RNA species, and their function depends on host cells. In cancer vaccines, however, these biogenic nanoparticles still have some limitations. Transferring tumor antigens and adjuvants to the secondary lymphoid system is a critical issue for biogenic nanoparticles. OMVs lack tumor antigens. Adjuvants are low in VLPs and exosomes. Furthermore, enhancing the protective response of biogenic nanoparticles, generating protective antigens in these nanoparticles and reducing the toxicity of nanoparticles are all challenges in cancer immunotherapy. There has been a lot of information regarding biogenic nanoparticles created by a variety of bacteria or cells in the area of bacterial vesicle research for a long time, but there has been a dearth of in-depth study focused on identifying molecules crucial to biogenesis or biogenic nanoparticles. Many basic questions remain unanswered here. Which envelope factors release biogenic nanoparticles? What signals and mechanisms regulate biogenic biogenic nanoparticles? Understanding these and other concepts as a cancer immunotherapy delivery technique is vital for the future development of biogenic nanoparticles. Future investigations are anticipated to begin to address these fundamental issues and increase our knowledge.
Medium, Small and Medium Enterprises (MSMEs) Digital Development
Authors: christanto angelia
Published: June 2021

During the COVID-19 era, companies must be able to adapt with changing business trends. Like adopting a digital platform, implementation of good corporate governance, analyze threat and take advantage of opportunities. This study uses a qualitative method with a case study approach that aims to increase the contribution of Medium, Small and Medium Enterprises (MSMEs) to Indonesian economic. The results of the research show that credit, training, and mentoring programs haven’t been able to raise small and medium enterprises, but still trying to increase the literacy index and financial inclusion to accelerate income distribution in Indonesia.
Preprint non-residential fatherhood and academic engagement among Curaçaoan and Dutch young people
Authors: Osinga Mariëlle , van Brummen- Girigori Odette , Kretschmer Tina
Published: June 2021

Growing up without biological father present in the home has been portrayed as disadvantageous for a range of child and adolescent outcomes. Yet, most studies focus on Western countries, lack cross-country comparisons, and look into outcomes of this family structure for children and young adolescents. As a consequence, we do not know whether correlates of non-residential fatherhood differ between countries and whether they exist in late adolescence and early adulthood as well. This study examined associations between non-residential fatherhood and academic engagement among Curaçaoan and Dutch adolescents and young adults on Curaçao and in the Netherlands. 528 Curaçaoan and 636 Dutch young people completed a digital questionnaire on household compositions and school-related behavioral and emotional (dis)engagement in educational settings in both countries. Because of measurement variance, we estimated structural equation models of academic engagement dimensions separately for Curaçaoan and Dutch participants. Growing up without biological father present in the home was not associated with academic engagement among Curaçaoan and Dutch participants. Additional analyses, however, showed that nonresidence of the biological father was negatively linked to Curaçaoan participants’ educational level. Associations between non-residential fatherhood and offspring later development might be more subtle and less systematic than existing literature suggests.
An Exploratory Psychometric Network Analysis of Loneliness Scales in a Sample of Older Adults.
Authors: Thompson Alexandra , Pollet Thomas Victor
Published: June 2021

Objectives: To examine the relationships within and between commonly used measures ofloneliness to determine the suitability of the measures in older adults. Further, todetermine items of key importance to the measurement of loneliness. Methods: Data wereobtained from 350 older adults via completion of an online survey. Four measures ofloneliness were completed. These were the UCLA Loneliness scale (Version 3), the de JongGierveld Loneliness Scale, the Social and Emotional Loneliness Scale for Adults (ShortVersion) and a direct measure of loneliness. Results: Analysis via a regularized partialcorrelation network and via clique percolation revealed that only the SELSA-Sencompassed loneliness relating to deficits in social, family and romantic relationships. Theremaining measures tapped mostly into social loneliness alone. The direct measure ofloneliness had the strongest connection to the UCLA item-4 and the de Jong Giervelditem-1 exhibited the strongest bridge centrality, being a member of the most clusters.Discussion: The results indicate that should researchers be interested in assessingloneliness resulting from specific relationships, then the SELSA-S would be the mostsuitable measure. Whereas the other measures are suitable for assessing loneliness moregenerally. The results further suggest that the de Jong Gierveld item-1 may be a moresuitable direct measure of loneliness than that currently employed as it taps into a greaternumber of relationships.
Moral Paragons, but Crummy Friends: The Case of Snitching
Authors: Berry Zachariah , Silver Ike , Shaw Alex
Published: June 2021

Loyalty to friends is an important moral value, but does that mean snitching on friends is immoral? Across four pre-registered studies, we examine how loyalty obligations impact people’s moral evaluations of snitching (i.e., turning in others who commit transgressions to relevant authorities). In vignette and incentivized partner choice studies, we find that witnesses who snitch (vs. do not snitch) are seen as more moral and as better leaders (Studies 1–4), regardless of whether they snitch on a friend or an acquaintance (Studies 1–2). Our experiments also demonstrate that snitches receive less moral credit when snitching on non-moral (vs. moral) transgressions (Study 2), and when snitching aligns with a self-interested motive (Study 3). We demonstrate that although snitching is often seen as morally right, turning in transgressors entails important reputational tradeoffs: Snitching makes one appear disloyal and a bad potential friend, but boosts perceptions of morality and leadership potential.
Water Pricing and Affordability in the US: Public vs Private Ownership
Authors: Zhang Xue , Rivas Marcela Gonzalez , Grant Mary , Warner Mildred E.
Published: June 2021

We examine the 500 largest community water systems in the US to explore if ownership is related to annual water bills and the percent of income that low-income households spend on water. Results show that, among the largest water systems, private ownership is related to higher water prices and less affordability for low-income families. In states with regulations favorable to private providers, water utilities charge even higher prices. Affordability issues are more severe in communities with higher poverty and older infrastructure. Water policy needs to address ownership and regulation and explore new mechanisms to ensure water affordability for low-income residents.
Mother-infant separations in prison: Why does context matter?
Authors: Martin Klare , Powell Claire
Published: June 2021

Mother-child separations are a gendered ‘pain of imprisonment’ leaving a legacy of further trauma for mothers on release, particularly those who are not reunited with their children. Building on Haney’s (2005) contextual approach, this chapter will present a co-produced qualitative analysis of research findings on separated mothers in prison. This collaboration between a mother with lived experience of the prison system (Martin) and a prison researcher (Powell) will draw on feminist criminological work reflecting on personal experience of the prison system. Interweaving lived experience reflections with a study of maternal imprisonment, we discuss how imprisoned mothers’ experiences of separation from their children are mediated by social support and wider systemic issues with the criminal justice system. Three aspects were emphasised by mothers and prison staff: 1) the impact of family relationships; 2) wider systems and agencies beyond prison; 3) prison mother-baby units. We propose that a contextual understanding of mothers’ experiences is needed to work towards mitigating the harms of mother-child separation.
ANALISIS MANAJEMEN BAZNAS DALAM PENGENTASAN KEMISKINAN
Authors: Pitri Alisyah
Published: June 2021

Kajian dalam buku ini bertujuan untuk mengetahui dan mendeskripsikan faktor-faktor yang mempengaruhi pola manajemen zakat di BAZNAS dalam hal pengumpulan zakat dan penyaluran kepada mustahiq. Selanjutnya untuk menganalisa manajemen BAZNAS bila dihubungkan dengan maqashid alSyariah zakat dalam pengentasan kemiskinan.
FIQIH IBADAH
Authors: WIGUNA SATRIA
Published: June 2021

Kehadiran buku ini adalah salah satu upaya dan usaha dari dosen dan para mahasiswa yang memiliki aspresiasi semangat menulis menjadi suatu hasil karya ilmiah yang berkualitas. Buku ini mengacu pada pembahasan thaharah dan bagian rukun Islam. Muatan materi pada bagian BAB buku ini mengacu pada kurikulum KKNI pada perguruan tinggi pada umumnya. Buku dapat dipergunakan pada mata kuliah perguruan tinggi Sarjana-1. Tujuan adanya buku fiqih ibadah ini sebagai pengangan atau panduan belajar mahasiswa Jam’iyah Mahmudiyah Tanjung Pura dan mahasiswa muslim pada umumnya. Buku Fiqih Ibadah membahas hukum Allah SWT yang berhubungan dengasn amaliah mukallaf yaitu wajib, sunah, mubah, makruh dan haram berdasarkan dalil yang jelas.
Evaluation of Efficacy of Online Case Based Learning as a Teaching Learning Tool in Undergraduate Oral Pathology Course
Authors: Shrestha Bijayata , Subedi Sushil , Koirala Ujjwal , Paudel Ishwori Sharma , Paudel Sabita
Published: June 2021

Introduction: COVID-19 had enforced educational institutes to adopt online learning.

Objectives: This study was designed to compare the learning outcome of online case and online lecture based learning in the undergraduate Oral pathology module of our institute and to compare the perception of students towards the course atiended.

Methodology: The 3rd year dental students (N=25) were split into – online case based learning (A1=6, A2=6) and online lecture based learning groups (B=13) randomly. An online multiple choice questions tests were conducted before and after the interventions. An online questionnaire based survey was conducted to evaluate students' perceptions toward the course attended. The statistical analysis was done using paired t test and Mann Whitney U test.

Results: Online case based learning was found to be a more effective learning method than online lecture based learning group (online case based learning post test mean rank=16, online lecture based learning post test mean rank=9.54, P=0.026). Significantly more students in the online case based learning group had positive perception towards the course atiended (online lecture based learning; mean value =2.5+/- 0.54, online case based learning; mean value =2.87+/-0.2, P=0.041).

Conclusion: Online case based learning should be integrated in Oral Pathology curriculum amidst such pandemics when onsite classes are not possible.
Use of Wrist or Ankle as Substitute Sites for Placement of Pulse Oximeter in Neonatal Intensive Care
Authors: Dahal Sonia , Rimal Hemsagar , Pyakurel Kumud , Adhikari Deep Raj
Published: June 2021

Introduction: Pulse oximetry is widely used in Neonatal intensive care setting. Both wrist and ankle are widely used as substitute sites for probe placement in place of more commonly used sites such as palm and sole. However, little is known about the accuracy and response time of pulse oximetry when the probe is placed at wrist or ankle of neonates.

Objectives: The primary objective of this study was to compare the values of SpO2 reading at wrist with palm and ankle with sole in terms of correlation and accuracy. The secondary objective was to compare the response time to get a valid SpO2 reading at wrist with palm and ankle with sole.

Methodology: This was a prospective observational study conducted at Neonatal intensive care unit of Biratnagar Hospital from October 2020 to January 2021. After approval from institutional review committee, a total of 152 consecutive neonates admitted in NICU of either gender both term and preterm were enrolled for the study. Recording of SpO2, heart rate and response time was done by two pulse oximeters simultaneously. The SpO2 measurements at right palm and right wrist were recorded at 0, 30 seconds and 1 minute then simultaneous recording was done for the left palm and left wrist, right sole and ankle and left sole and ankle. Response time was also recorded for each of the readings.

Results: The results of our study show good correlation using regression analysis and good agreement using Bland- Altman plots between the values of SpO2 reading of paired measurements. The response times of the paired measurements were not significantly different. There was good correlation between the SpO2 of paired measurements. The correlation for right palm and wrist was 0.927 (P-value = 0.01) and that of left palm and wrist was 0.85 (P-value = 0.01). Similarly the correlation between right sole and ankle and left sole and ankle were 0.937 (P-value = 0.01) and 0.875 (Pvalue = 0.01) respectively. The bias (average difference) and precision (standard deviation of differences) were calculated. The bias and precision of the right palm and wrist, left palm and wrist, right ankle and sole; and left ankle and sole were (-0.00289, 0.76105), (-0.17982, 0.95049), (-0.03509, 0.786342) and (-0.14474, 0.859241) respectively.

Conclusion: Wrist and ankle can be used as substitute sites for pulse oximter placement in neonatal intensive care setting.
Toxidade dos inseticidas químicos sobre espécies de Isaria
Authors: Lopes Rosineide da Silva , Lima Geiziquele de , Oliveira Luciana Gonçalves de , Costa Antonio Félix da , Correia Maria Tereza dos Santos , Lima Elza Áurea de Luna Alves , Lima Vera Lúcia de Menezes
Published: June 2021

O controle de insetos-praga é usualmente realizado com produtos químicos, os quais podem contaminar o homem e o meio ambiente. O trabalho teve por objetivo avaliar o efeito tóxico dos inseticidas clorpirifós, acetamiprid, thiamethoxan e lambacyhalothrin sobre espécies de Isaria, visando à utilização destes agentes biológicos no controle integrado de insetos-praga. Os inseticidas foram adicionados ao meio Ágar Sabouraud e à solução Tween 80 (0,1%), em três concentrações preestabelecidas de acordo com as recomendações do fabricante.
Domácias e ácaros em cafeeiros
Authors: Mineiro Jeferson Luiz de Carvalho , Sato Mário Eidi , Raga Adalton
Published: June 2021

Domácia é de origem grega “domatium” e que significa casa pequena. Essas estruturas foram interpretadas como “adaptações a uma simbiose mutualística entre a planta e os ácaros que ali vivem”, mas esta teoria foi logo abandonada pelos botânicos, que passaram a utilizar o termo domácia apenas para as estruturas presentes nas junções das nervuras das folhas. Pouco se conhece a respeito da função das domácias em cafeeiro.
La hora del cuento en la biblioteca pública. Un análisis de las prácticas de lectura
Authors: González de la Torre Yolanda
Published: June 2021

El objetivo de este trabajo fue identificar y analizar algunas prácticas de lectura visibles en una biblioteca pública de Guadalajara, México. Desde una perspectiva sociocultural que considera la lectura como una práctica, se reconocen las condiciones y demandas que enfrenta el lector en un determinado espacio y lo llevan a desarrollar la actividad lectora de cierta manera. Se eligió como espacio de indagación “La hora del cuento”, actividad dirigida a un grupo infantil de visitantes asiduos de esa biblioteca. Los instrumentos para la recolección de datos fueron la observación, que permitió registrar las acciones de quienes intervinieron en las actividades de lectura, y la entrevista a las bibliotecarias y participantes de la actividad, que dio cuenta de algunas de sus percepciones sobre el fomento de la lectura y la formación de lectores. Los resultados indican que las prácticas en ese lugar se centran en la difusión del acervo, así como en acentuar rasgos del lector valorados en la cultura escolar, como la fluidez lectora, a través de ejercicios como la lectura en voz alta.
Literacidad a partir de realidades integradoras
Authors: Romo Sabugal Claudia
Published: June 2021

El objetivo de este artículo es mostrar el proceso de construcción y descubrimiento que permitió determinar las características de un método alfabetizador capaz de asegurar un aprendizaje eficaz de la lengua escrita a partir del trabajo con realidades integradoras, mediadas por la reflexión que los docentes pueden emplear en el aula para desarrollar la literacidad. Este aprendizaje se presenta como resultado de un proceso cualitativo de investigación-acción del cual deriva una propuesta que aborda la literacidad como una alternativa para la alfabetización que permite que la experiencia de aprendizaje sea continua, dinámica, lúdica y vinculada a la realidad del niño y la niña.
Inclusive education as a component of social work
Authors: Potishchuk Olga , Rudenko Tamara
Published: June 2021

The article considers inclusive education as one of the areas of development of children with disabilities. Modern society makes demands on the field of education, which is a main part of society. Nowadays, education is available at the state level. Inclusive education is based on a social model of equal rights and freedoms for people with disabilities. The experience of European countries has shaped the treatment of people with disabilities internationally, bridging the gap between people with disabilities and society. An inclusive educational environment in Ukraine requires innovative support. The problem of inclusive education in Ukraine is insufficiently developed, which increased the relevance of the study. There is a need for highly qualified social educators and social workers.

The role and features of inclusive education, which provides comfortable and humanistic development, integration of children with disabilities, are studied. The experience of inclusive education of foreign countries in the United States of America and Israel has been considered. The international and Ukrainian legal framework is analyzed. It is determined that new approaches, methods for revealing abilities, creative potential, education of harmonious personality, etc. arise and are formed within the framework of inclusive education. The social policy of states is aimed at inclusive education development as the main component of social work.
Socio-pedagogical research of detecting manipulative manifestations in students’ interpersonal relations
Authors: Rіabinina Marуna
Published: June 2021

The article highlights the problem of manipulative manifestations in interpersonal relationships of students of general secondary education. Different points of scientists' view on the admissibility of manipulation in interpersonal communication of school students have been considered.

Today researchers do not pay enough attention to the detecting of manipulative manifestations in the interaction of students of general secondary education, as well as socio-pedagogical diagnosis of personal characteristics of adolescents prone to manipulation. Scientists consider the use of manipulative techniques as an unacceptable means of socio-pedagogical and psychological influence because manipulation encourages others to perform actions which are contrary to the people's interests. In addition, it is necessary to establish the socio-pedagogical consequences of the threat of negative manifestations of manipulation in the educational sphere.

The purpose of this article is to study and analyze the problems of manipulation in interpersonal communication between students of general secondary education, as well as to identify the personal authorities of students, school to manipulation, or, conversely, unable to resist it. To date, researchers have not proposed a holistic and systematic model of diagnosis and prevention of manipulation in the interaction of adolescent students. A small number of empirical studies would show not only the result but also nature of the impact of manipulation on the relationship between participants in the educational process. The question of the use of manipulation in the socio-pedagogical aspect is insufficiently studied.

Observation of students' behaviour during the experiment shows that manipulations are widely used in adolescence. It is established that the issue of manipulative influence and manifestations of manipulation in interpersonal relations of students by the humanities, especially social pedagogy and social psychology, remains open and not fully explored. The prospect for further research is the development and implementation of a training program for the prevention of manipulative manifestations in interpersonal relationships of school students, as well as providing methodological assistance to professionals who face this problem.
Social education of youth by means of museum pedagogy
Authors: Krylovets Mykola
Published: June 2021

On the path of social transformations and processes of European integration in Ukraine, many measures are taken to reform certain areas of activity, rethink and implement new, more effective, forms of rationalization of public life. One of the innovative directions of this reform is the museum pedagogy introduction in the educational process, which necessitates the scientific study of its use as the subject of social and educational work with different categories of youth.

The article considers the possibilities of implementing the socio-cultural component of modern museums for various purposes in improving the educational process and social education of young people through museum pedagogy. The socio-cultural component is understood as the spiritual world created by mankind, which encompasses national, social, economic, political and other social relations and spiritual and cultural values developed by mankind throughout history, which influence people, shape their worldview, in particular, determine behaviour in relations with others. environment and among themselves. The socio-cultural component of the content of museums affects not only the cognitive side of students' self-knowledge but also contributes to the formation of ideas, values, self-esteem. During excursions in the museum, the mental, labour, moral, aesthetic, economic education of students is actively carried out. Through the knowledge and skills acquired in the museum, the knowledge of the world, history and culture of one's own and other people are deepened, the basis for theoretical judgments is created, the consciousness of the young personality is formed. Museum pedagogy has great opportunities to learn about new trends in modern science and modern research, to educate oneself as a researcher, analyst, to develop observation, the ability to make generalizations and predictions. Museum pedagogy helps not only to maximize the educational and cultural potential of museums but also allows graduates based on a system of acquired knowledge, skills and abilities to self-determine in a changing world, to continue education in the chosen field.
ÇOCUK KİTABI İLLÜSTRASYONLARI VE DİJİTAL KOLAJ İLLÜSTRASYON TEKNİĞİ ÜZERİNE BİR DEĞERLENDİRME
Authors: KILIÇ Ali
Published: June 2021

Günümüzde pek çok kontrolsüz görüntüye maruz kalan çocuğun, kaliteli öğrenmenin olduğu alana çekilebilmesi için, görsel karmaşanın yeniden düzenlenmesi ve nitelikli imajların işaret edilmesi gereklidir. Birçok farklı tür görsel içeren çocuk metinleri; masallar, hikâyeler, hayal gücünü besleyen fantastik metinler, dil oyunları içeren resimli anlatılar, şiirler ve şarkıları kapsamaktadır.

Çocuklar ve kitaplar arasında bir köprü oluşturmak ve anlatı becerileri kazandırmak açısından resimli kitaplar, çocuk edebiyatında zihinsel ve görsel iletişim kaynağı olma görevini üstlenmiş önemli araçlardır. Bu kitaplar ile bilgi, sözel ve görsel kodların bir kombinasyonu olarak çocuğa iletilebilmektedir. Bu nedenle çocuk dünyasını inşa etme görevini üstlenen resimli kitaplarda görüntü ve metin karşılıklı olarak etkileşim içinde olmalı ve metnin işlevine uygun biçimler içermelidir.

Yeni çağın kitap resimlemeleri birçok dijital gösterge barındırmaktadır. Pedagojik anlamda çocuğun faydalanabileceği bu görseller, çocuğun bilişsel gelişimine karşılık gelmeli ve görsel algı düzeyine uygunolmalıdır.

Günümüz resimli kitaplarında kullanılan dijital yöntemler illüstratör için kullanım kolaylığı ve konforu açısından giderek daha popüler hale gelmektedir. Geleneksel ve çağdaş tekniklerin melezleştiği bu yöntemler ile çizer, keyifli ve seri çalışabilme fırsatı bulmaktadır.

Kolaj illüstrasyon birçok çocuk kitabı illüstratörü tarafından -naif anlatım olanakları vermesi açısından- tercih edilmektedir. Günümüzde kolaj illüstrasyon, geleneksel ve dijital tekniklerin harmanlandığı “tradijital” teknikler ile oluşturulmaktadır.

Bu çalışmanın amacı; çocuğun büyüme materyallerinden biri olan resimli kitapların, çocuk dünyasına olan etkisini ve dijital yazılımların, geçmişten gelen geleneksel resimleme teknikleri ile hangi koşullar altında bir araya geldiklerini kolaj illüstrasyon uygulamaları üzerinden değerlendirmektir.
MAX ERNST’İN RESİMLERİNDEN ÇÖZÜMLEME ÖRNEKLERİ: “SESSİZLİĞİN GÖZÜ”, “YAĞMURDAN SONRA AVRUPA II”, “ANTIPOPE”*
Authors: KAYAPINAR Umut
Published: June 2021

Mitlerde; Görünen dünya görünmeyen bir öte dünya ile desteklenmiştir. Mitler, bilinçaltı ve yaşamsal alanın gerekleri üzerinden kurgulanırken, daha çok belli bir tapınma ve bağlanma isteği duyan insanın hayal gücünün derinliğine işaret etmektedir. Bu durumda yaşanılan coğrafyada çeşitli kültür farklılıkları ile birlikte mitolojik hikâyeleri ve tanrıların varlığını betimleme üzerine kurgulandığını göstermektedir. Sanatta mitolojik hikâyeler konu olarak ele alınmış ve her dönemde kendine yer bulmuştur. Mitoloji, Jung ve Freud gibi Psikanalistlerin ön ayak olduğu akımlarda da etkin biçimde yer alırken; Sürrealizm akımında başta Dali olmak üzere birçok sanatçının da bu konuyu ele aldığını görülür. Bu sanatçıların en önde gelenlerden biri de Max Ernst’tir. Ernst, “Sessizliğin Gözü”, “Yağmurdan Sonra Avrupa II”, “Antipope” adlı çalışmaları; hayali manzaraları, sürrealistlerin tasavvurunda kristalde cisimleşen sarsıcı güzelliğin en iyi görüntüleri arasındadır. Bunlar sıradan insanın değil, doğada var olan bir canlının gözünden nesnelleşmektedir. Yapıtların alt metni çok zengin ve bir bulmaca gibi şifrelidir. Tek gözün manası değişkendir. Bir yandan gözün fizyolojik konumuna göre insanlıktan farklı bir tarafa işaret ederken, öte taraftan mitolojide tek gözlü devlerde vücut bulan, insan ötesi güçleri akla getirir. Bu çalışmada Ernst’in “Sessizliğin Gözü Adlı, Yağmurdan Sonra Avrupa II, Antipope” yapıtları ikonolojik analizi mit, mitoloji ve sanat bağlamında ele alınıp çözümlenecektir.
Regard critique sur le Rapport « Les 1 000 premiers jours. Là où tout commence »
Authors: Roegiers L.
Published: June 2021

Le Rapport des 1 000 premiers jours repose sur les concepts suivants. Il étend la notion d’interaction entre le bébé et son environnement signalée par l’Unicef à plusieurs dimensions : biologique, sensorielle, interactive et culturelle, toutes cibles de la prévention précoce. Il confirme que la période périnatale est déterminante pour soutenir le développement de l’enfant. Il invite à entourer les jeunes parents par une équipe cohérente et des contacts entre parents pour briser la solitude. Enfin, outre les moyens logistiques à dégager, il priorise la formation interdisciplinaire. Cet article développe de façon critique les points forts du Rapport en proposant quelques points d’attention pour en améliorer le contenu. Par exemple, il s’agit de ne pas confondre prévention personnalisée et prévention collective. Ou encore, audelà de l’outil « information », il est bon de faire éprouver par les jeunes parents le processus d’ajustement des professionnels à eux, modèle de caregiving pour eux face à leur bébé. Et il faut s’appuyer sur les dynamiques positives dans les situations à risque. Après ce beau travail se présente le défi politique de son implémentation.
SEGURANÇA E SAÚDE DOS TRABALHADORES NOS SERVIÇOS DE TELECOMUNICAÇÕES
Authors: José Hélio Lopes Batista , Maurício Barbosa de Lima , Augusto Cesar Cabral Santos , Felipe José Lemos Duarte , Luciano José dos Santos , Raphael Queiroz de Holanda Padilha
Published: June 2021

Para além das questões salariais e econômicas, o Sinttel-PE sempre se pautou pelo enfrentamento dos aspectos relacionados à saúde e segurança dos trabalhadores. É um esforço que vem sendo construído com base nos anseios e interesses da nossa categoria. Tendo como foco a prevenção dos acidentes e doenças decorrentes do trabalho, a presente cartilha é voltada aos empregados que implantam e realizam manutenção da rede externa em telecomunicações. Assim, esta publicação constitui uma ferramenta valiosa nas mãos dos trabalhadores, socializando informações para ampliar a sua luta por um trabalho seguro digno e saudável.
Understanding Terrorism: A Review of the Psychosocial Theories
Authors: Jameel Arif , Ahmad Riaz , Mehdi Mudassir
Published: June 2021

Terrorism is a cause of uncertainty, fear, and damage for a country. Mostly represented stereotypically, terrorists are the reason for civil unrest worldwide. However, there are different approaches to describe the personality traits of a terrorist still this matter is highly debatable. This study aims to address terrorism from a psycho-social perspective. By describing the background dynamics of terrorism, the researchers extensively discussed the Social and Psychological reasons for adapting terrorism. The researchers discussed it in the light of different theories proposed by renowned psychologists and sociologists worldwide. Therefore, it is concluded that the psychological images of terrorists tend to reinforce social narratives which further lead to the creation of certain stereotyped attributions. In this regard, highlighting the adaptation of terrorism in the context of behaviorism can be of greater pertinence to effectively counteract this civil unrest.
Post Covid-19 Comparison between Chinese and North American Film Industry: A Systematic Review of the Year 2020 Cinema
Authors: Shah Mudassar Hussain , Yaqoub Muhammad , Jingwu Zhang
Published: June 2021

This article analyzes the Chinese post-Covid-19 cinema and compares it with the developments in North American Cinema. Coronavirus disease has significant detrimental effects on the worldwide film industry, and the annual box office of major film industries has seen a severe decline. This study presents the systematic review of the comparison of Chinese and North American Cinema during the year 2020. In this study, researchers have opted for the deductive approach on secondary source data with the keywords “Post Covid-19 Cinema”, “Chinese Film Culture Industry”, “Hollywood”, “Box Office”, and “Film Academy” on google search and consider all the significant sources in this systematic review. The Findings of the study reveal that China has already overtaken North America as the global most extensive box office crown for the first time, showing that in the post-COVID-19 era, the Chinese film industry is indeed among the first to get back on its feet.
Exporting the JF-17 Thunder: A way-out for Pakistan
Authors: Ali Ahmed , Khan Fida Muhammad
Published: June 2021

Pakistan is facing a current account deficit. Boosting exports will help reduce the deficit and fetch the much needed foreign exchange. Exports of defense products can provide Pakistan economy with a major boost. The paper presents a discussion on the various benefits Pakistan can have if the defense products such as the JF-17 thunder, which is a multi-role jet fighter produced by PAC Kamra and CAC China, is sold. The research approach as adopted in this paper is qualitative. The possible markets for the Pakistani JF-17 have been identified. The paper recommends that the political leadership should effectively utilize its diplomatic channels in order to secure sales for Pakistan's JF-17's thunder. The successful sale of the aircraft would not only boost our economy but will also make Pakistan rise in the comity of nations.
Global Climate Change: A Threat Multiplier to Pak- Afghan Constrained Relations
Authors: Goraya Naheed S. , Gul Shabnam , Alam Aftab
Published: June 2021

Pakistan and Afghanistan both are underdeveloped states and totally depended on agriculture for their economic spine. Terrorism issues with massive liability shortfall, susceptible set-up, bad governance, huge corruption, widespread poverty and extensive protection disbursement share the issues and issues of both countries. Global Climate Change and weather trade, and enlarging risk, foretells disastrous consequences on agriculture. The South Asian Region generally and PakAfghan particularly vulnerable to Challenges due to the weather change, consisting of, quickly melting Himalayan glaciers resultant in water shortage, low farming harvests main to meals lack confidence, threatened seashores, and people movement are causal to the emergencies of individualism and power between two important neighbours. These multidimensional factors of imminent issues have generated a debate to appear past the out-of-date coast-to-coast security constraints and comprise the environmentalist model of security, which calls for developing the variation ability of a state.
NILAI TAMBAH UMBI TIKE MENJADI KERIPIK TIKE PADA INDUSTRI RUMAH TANGGA
Authors: Hijrah Rachmat Perbawa , Juswadi Juri , Sumarna Pandu
Published: June 2021

Penelitian ini dilakukan di Desa Jumbleng Kecamatan Losarang Kabupaten Indramayu yang mengolah umbi tike menjadi keripik tike sebanyak 4 responden. Hasil penelitian mengenai pengolahan umbi tike menjadi keripik tike di UKM Desi, UKM tersebut memproduksi keripik tike menjadi 3 kemasan yang berbeda, yaitu kemasan yang mempunyai berat 100 gram dengan nilai tambah Rp 69.739,96 dan rasio nilai tambah sebesar 77,49%, kemasan 500 gram dengan nilai tambah yang diperoleh sebesar Rp 77.429, 96 dan rasio nilai tambah sebesar 77,43%, dan 1.000 gram yang memperoleh nilai tambah sebesar Rp 63.229,96 dengan rasio nilai tambah sebesar 70,26%. UKM Dhe-dhe Tyas memproduksi keripik tike menjadi 2 kemasan yang berbeda, yaitu kemasan yang mempunyai berat 100 gram dengan nilai tambah sebesar Rp 90.596,77 dan rasio nilai tambah sebesar 82,36% dan 1.000 gram dengan nilai tambah sebesar Rp 67.942,32 dan rasio nilai tambah sebesar 75,49%. Keripik tike Bapak Nano memproduksi keripik tike menjadi 2 kemasan yang berbeda, yaitu kemasan 100 gram dengan nilai tambah yang diperoleh sebesar Rp 90.501,83 dan rasio nilai tambah sebesar 82,27% dan 1.000 gram dengan nilai tambah sebesar Rp 71.729,49 dan rasio nilai tambah sebesar 79,70%. Sedangkan Industri Rumah Tangga Bapak Imam memproduksi keripik tike menjadi 3 kemasan yang berbeda, yaitu kemasan yang mempunyai berat 100 gram dengan nilai tambah sebesar Rp 82.739,44 dan rasio nilai tambah sebesar 82,74%, 500 gram dengan nilai tambah sebesar Rp 81.659.44 dan rasio nilai tambah sebesar 81,66%, dan 1.000 gram dengan nilai tambah yang diperoleh sebesar Rp 70.309,44 dan rasio nilai tambah sebesar 78,14%. Artinya nilai tambah yang diperoleh 4 responden tersebut tergolong tinggi karena rasio nilai tambahnya lebih dari 50%.
HUBUNGAN PENGETAHUAN DAN PENGALAMAN PADA SIKAP DAN PENGARUH SIKAP PADAPERILAKU PEMBELIAN
Authors: Fadilah Arsy Nur , Suryantini Any , Darwanto Dwidjono Hadi
Published: June 2021

Penelitian ini bertujuan untuk megetahui (1) pengaruh pengetahuan dan pengalaman konsumen terhadap sikap konsumen dalam pembelian brownies Cokro Tela, (2) pengaruh sikap konsumen terhadap perilaku pembelian brownies Cokro Tela yang berbahan baku mocaf. Responden merupakan konsumen brownies Cokro Tela. Responden dalam penelitian ini berjumlah 80 orang yang diambil secara Purposive sampling.Metode penelitian yang digunakan yaitu metode survei. Model SEM-PLS digunakan untuk menganalisis diagram jalur antarasatu variabellaten ke variabel laten lainnya dan variabel laten ke indikatornya. Variabel laten meliputi pengetahuan, pengalaman, sikap dan perilaku pembelian pada konsumen. Hasil penelitian menunjukan bahwa pengetahuan tidak berpengaruh secara signifikan terhadap sikap, sedangkan pengalaman berpengaruh siginifikan terhadap sikap dan sikap berpengaruh signifikan terhadap perilaku pembelian brownies Cokro Tela.
Deskripsi Kegiatan Disertai Identifikasi Potensi dan Kendala Kelompok Tani dalam Usahatani Mangga (Studi Kasus di Kelompok Tani Datar Indah dan Samoja)
Authors: Rasmikayati Elly , Djuwendah Endah , Mukti Gema Wibawa , Saefudin Bobby Rachmat , Wati Fitriana
Published: June 2021

Kelompok tani merupakan sebuah lembaga yang memiliki fungsi untuk memfasilitasi petani dalam melakukan kegiatan agribisnis dari hulu hingga hilir. Namun pada kenyataannya, harapan mengenai fungsi kelompok tani belum sepenuhnya terwujud. Penelitian ini bertujuan untuk: 1) Mendeskripsikan kegiatan kelompok tani dalam menjalankan fungsinya pada usahatani mangga di Kecamatan Sedong; dan 2) Mengidentifikasi apa saja potensi dan kendala yang dihadapi oleh kelompok tani dalam kegiatan usahatani mangga. Penelitian ini dilakukan di dua kelompok tani yang berbeda di Kecamatan Sedong, Kabupaten Cirebon yaitu Kelompok Tani Datar Indah dan Kelompok Tani Samoja dengan total responden sebanyak 45 responden. Teknik analisis data yang digunakan dalam penelitian ini adalah analisis data primer dan sekunder. Hasil penelitian menunjukkan, pada kelompok tani Datar Indah dalam satu tahun terdapat 15 kegiatan yang dilakukan bersama, terdiri dari pertemuan anggota, penyuluhan, dan penyaluran bantuan. Namun sebanyak 70% anggota hanya mengikuti kegiatan sebanyak 6-10 kali dalam satu tahun. Sedangkan kelompok tani Samoja mengadakan kegiatan yang sama dengan poktan Datar Indah dengan jumlah rata-rata 10 kali dalam satu tahun di mana hampir 60% anggotanya mengikuti sebanyak 4-6 kali dalam satu tahun. Sementara itu, potensi yang dimiliki oleh kedua kelompok tani adalah peningkatan daya tawar petani, mempercepat pemecahan masalah, dan pengenalan teknologi baru. Sedangkan kendala yang dialami oleh kelompok tani berupa kurangnya motivasi petani, kurangnya kesadaran akan peran kelompok tani, kesibukan petani, dan kurangnya tenaga penyuluh.
Kinderrechtsforschung auf der Suche nach einem eigenen Profil
Authors: Liebel Manfred
Published: June 2021

Die Kinderrechtsforschung versteht sich als ein wissenschaftliches Feld mit spezifischen Erkenntnisinteressen und Fragestellungen, die sich von denen anderer Forschungsfelder, z.B. der Kindheitsforschung, signifikant unterscheiden. Sie untersucht die Entstehungsgründe der Kinderrechte ebenso wie ihre Bedeutungen und Wirkungen im Leben der Kinder. In der bisherigen Debatte lassen sich einige Gemeinsamkeiten erkennen, aber es stellen sich auch Fragen, wie ihr Profil zu schärfen, zu erweitern und neu zu akzentuieren ist. Der Essay diskutiert einige dieser Fragen und formuliert Überlegungen zu den weiteren Perspektiven einer interdisziplinären Kinderrechtsforschung. Insbesondere geht er auf ihr Rechtsverständnis, die politischen Implikationen der Kinderrechte, das Konzept der Living Rights und das spannungsreiche Verhältnis von Forschung und politischem Aktivismus ein.
Muers, Stephen (2020). Culture and Values at the Heart of Policy Making. An Insider's Guide. Bristol: Policy Press.
Authors: Jann Werner
Published: June 2021

This book is a forceful and entertaining argument why culture and values should be taken much more seriously, both by policy makers, but also in the curricula of modern Public Policy and Public Administration programs. The author is not a fundamental sceptic of managerial politics and administration, but he shows the inherent limits, contradictions, and blind spots of this kind of policy making. He succeeds particularly well because he can draw on many years of experience as a civil servant in different British ministries, in the Cabinet Office and the Prime Minister's Strategy Unit. The book adds little to the conceptual and theoretical discussions of cultural factors in policy making, but it does provide many interesting examples of their significance and why it is dangerous to ignore them. It should be read by students in advanced public policy and public administration programs, who should find it helpful to see the technical solutions to all sorts of policy problems in a somewhat more realistic light.
Graycar, Adam (Ed.) (2020). Handbook of Corruption, Ethics and Integrity in Public Administration. Cheltenham: Edward Elgar Publishing. 512 pp. ISBN: 978 1 78990 090 3.
Authors: Meyer-Sahling Jan-Hinrik
Published: June 2021

Das Handbook of Corruption, Ethics and Integrity in Public Administration wird ein zentrales neues Nachschlagewerk sein für Wissenschaftler*innen, die öffentliche Verwaltungsforschung und Korruptionsstudien zu verbinden suchen. Der Band befasst sich mit dem Kontext der öffentlichen Verwaltung, seinem Wandel und den jeweiligen Auswirkungen auf Korruptionsrisiken; er untersucht Korruptionsfragen nach Politikfeldern und bietet damit einen neuartigen, von der Politik- und Verwaltungsforschung inspirierten Ansatz für Korruptionsstudien; er bietet eine internationale Übersicht von Anti-Korruptionsreformen aus zwölf Ländern; und er endet mit innovativen Diskussionen zu Erfahrungswerten und Erfolgsfaktoren der Korruptionsbekämpfung sowie mit Schlüsselkonzepten wie „Interessenkonflikten“ und „Integrität“ in der öffentlichen Verwaltung. Das Handbuch entwickelt abschließend Vorschläge, wie die Korruptions- und öffentliche Verwaltungsforschung sich gegenseitig weiter inspirieren und informieren können, insbesondere in Bezug auf die Messung von Korruption und die Auswirkungen von institutionellen Arrangements und Managementpraktiken in der öffentlichen Verwaltung.
HPV-associated penile cancer: Impact of copy number alterations in miRNA/mRNA interactions and potential druggable targets
Authors: Silva Jenilson da , Nogueira Leudivan , Coelho Ronald , Deus Amanda , Khayat André , Marchi Rafael , Oliveira Edivaldo de , Santos Ana Paula dos , Cavalli Luciane , Pereira Silma
Published: June 2021

BACKGROUND: Penile cancer (PeCa) is a rare disease, but its incidence has increased worldwide, mostly in HPV+ patients. Nevertheless, there is still no targeted treatment for this carcinoma. OBJECTIVE: To predict the main signaling pathways involved in penile tumorigenesis and its potential drug targets. METHODS: Genome-wide copy number profiling was performed in 28 PeCa. Integration analysis of CNAs and miRNAs and mRNA targets was performed by DIANA-TarBase v.8. The potential impact of the miRNAs/target genes on biological pathways was assessed by DIANA-miRPath v.3.0. For each miRNA, KEGG pathways were generated based on the tarbase and microT-CDS algorithms. Pharmaco-miR was used to identify associations between miRNAs and their target genes to predict druggable targets. RESULTS: 269 miRNAs and 2,395 genes were mapped in cytobands with CNAs. The comparison of the miRNAs mapped at these cytobands and the miRNAs that were predicted to regulate the genes also mapped in these regions, resulted in a set of common 35 miRNAs and 292 genes. Enrichment pathway revealed their involvement in five top signaling pathways. EGFR and COX2 were identified as potential druggable targets. CONCLUSION: Our data indicate the potential use of EGFR and COX2 inhibitors as a target treatment for PeCa patients.