bluuebunny/crossref_metadata_2025 huggingface dataset:
A Polymeric Vesicle System for Combined Lung Cancer Therapy through Chemotherapy and Vasculature Normalization
Authors: Wang Ding , Qiu Cheng-Jie , Chu Yaoqing , Zhang Anzhuo , Huang Ran , Pan Si-Jian , Tan Lianjiang
Published: November 2024

Lung cancer remains a great threat to human health despite the rapid development of various therapeutic methods. Chemotherapy continues to be the most commonly employed treatment for lung cancer; however, it often suffers from low drug delivery efficiency and severe side effects. To enhance the therapeutic efficacy of chemotherapy, we developed a novel strategy that integrates tumor vasculature normalization with the co-delivery of therapeutic agents. This strategy employs a diblock polymeric vesicle with a reduction-sensitive linkage. Paclitaxel (PTX) is encapsulated in the bilayer, while an acid-sensitive nitric oxide (NO) precursor, DETA NONOate, and zinc oxide nanoparticles (ZnO NPs) are loaded into the central cavity. The resulting nanosystem, (ZnO,NONO)@Ves-PTX, is designed to release NO under the acidic conditions typical of the tumor microenvironment (TME) and intracellular environment. The released NO in the TME inhibits angiogenesis, thereby facilitating the delivery and distribution of therapeutic agents. Upon internalization by tumor cells, (ZnO,NONO)@Ves-PTX decomposes in response to intracellular glutathione (GSH), releasing the loaded agents. DETA NONOate and ZnO NPs generate NO and Zn
2+
ions, respectively, at the intracellular pH, which synergistically inhibit tumor growth alongside PTX. This combined therapeutic approach demonstrated remarkable potential in improving the chemotherapeutic efficacy for lung cancer, offering a promising direction for future cancer treatments.
Evolution of Global Terrestrial Gross Primary Productivity Trend
Authors: Wang Zihao , Peñuelas Josep , Tagesson Torbern , Smith W. K. , Wu Mousong , He Wei , Sitch Stephen , Wang Songhan
Published: November 2024

Increased global vegetation gross primary productivity (GPP) over the past decades has led to an enhanced terrestrial carbon sink, an important factor in mitigating global warming. However, the global spatiotemporal evolution of GPP trends is still under debate, largely limiting our understanding of the sustainability in terrestrial carbon sink. Here in this study, based on a dozen of long-term global GPP datasets, we found that global GPP trends fell significantly from 0.43 PgC year
−2
in 1982–1999 to 0.17 PgC year
−2
in 2000–2016, a signal detected across >68% of the terrestrial surface. The decrease in GPP trends was more pronounced from satellite-based GPP datasets than from process-based models, which may result from a decline in the CO
2
fertilization effect. This finding therefore indicates that the terrestrial carbon sink may become saturated in the future, and highlights the urgent need of stricter strategies for reducing carbon emissions to mitigate global warming.
Advanced Functional Optical Fiber Sensors for Smart Battery Monitoring
Authors: Liu Zhi , Lu Yang , Ma Xiao , He Yun , Fu Mingzhe , Yan Shuaishuai , Li Changjian , Song Xuan , Zhou Haiyu , Liu Kai
Published: November 2024

With the increasing demand for batteries, the real-time in situ monitoring of the physical/chemical state within the “black box” is critical to improving battery performance. Consequently, the development of a cost-effective and in situ battery monitoring system that does not interfere with the normal operation of the battery is imminent. Traditional monitoring techniques are constrained by size, reliability, and scalability. Optical fiber sensors offer a distinctive advantage in enabling highly sensitive, multiparameter in situ measurements in the harsh electrochemical environment of batteries. By decoding these characteristic parameters, it helps to establish the evolution mechanism of the battery’s safety state. Additionally, the integration of advanced lab-on-fiber technology with battery monitoring systems has attracted considerable attention. This review summarizes the recent advances in optical fiber sensing technology in the fields of battery temperature and mechanical stress/strain and provides an outlook on the future challenges and development of smart batteries.
Leukocyte Telomere Length and Polycystic Ovary Syndrome: A Transethnic Mendelian Randomization Study
Authors: Cao Lan , Chen Jie
Published: November 2024

Objective:
Observational studies have reported conflicting results on the association between leukocyte telomere length (LTL) and polycystic ovary syndrome (PCOS). This study evaluated the causal effect of LTL on PCOS in European and East Asian populations using Mendelian randomization (MR).
Methods:
Genetic variants for LTL were selected as instrumental variables from the largest genome-wide association study (GWAS) from the UK Biobank (472,174 participants) and a Singapore Chinese GWAS (23,096 participants). Two-sample MR analysis was performed in a PCOS cohort of European ancestry (4,138 cases and 20,129 controls), with replication analyses in a Northern European PCOS cohort (3,609 cases and 229,788 controls) and in a Chinese PCOS cohort (4,386 cases and 8,017 controls). A reverse MR study was conducted to test the effect of PCOS on LTL.
Results:
In the PCOS cohort of European ancestry, genetically determined longer LTL was associated with lower risk of PCOS according to the inverse-variance weighted method [odds ratio (OR), 0.709; 95% confidence interval (CI), 0.506 to 0.992;
P
= 0.045]. The results remained directionally consistent in sensitivity analyses using different MR methods. In the Northern European replication cohort, a significant association was also found between genetically determined longer LTL and lower risk of PCOS via the MR–Egger method (OR, 0.580; 95% CI, 0.351 to 0.961;
P
= 0.038). Similar associations were observed in the East Asian replication cohort but did not reach nominal significance. In the reverse MR analysis, no evidence of associations was observed between genetically determined PCOS and LTL in either Europeans or East Asians.
Conclusion:
This study revealed evidence supporting a causal role of LTL in the etiology of PCOS.
Quantification of Carbon Stocks at the Individual Tree Level in Semiarid Regions in Africa
Authors: Perpinyà-Vallès Martí , Machefer Mélissande , Ameztegui Aitor , Escorihuela Maria José , Brandt Martin , Romero Laia
Published: November 2024

Quantifying tree resources is essential for effectively implementing climate adaptation strategies and supporting local communities. In the Sahel, where tree presence is scattered, measuring carbon becomes challenging. We present an approach to estimating aboveground carbon (AGC) at the individual tree level using a combination of very high-resolution imagery, field-collected data, and machine learning algorithms. We populated an AGC database from in situ measurements using allometric equations and carbon conversion factors. We extracted satellite spectral information and tree crown area upon segmenting each tree crown. We then trained and validated an artificial neural network to predict AGC from these variables. The validation at the tree level resulted in an
R
2
of 0.66, a root mean square error (RMSE) of 373.85 kg, a relative RMSE of 78.6%, and an overestimation bias of 47 kg. When aggregating results at coarser spatial resolutions, the relative RMSE decreased for all areas, with the median value at the plot level being under 30% in all cases. Within our areas of study, we obtained a total of 3,900 Mg, with an average carbon content per tree of 330 kg. A benchmarking analysis against published carbon maps showed that 9 out of 10 underestimate AGC stocks, in comparison to our results, in the areas of study. An additional comparison against a method using only crown area to determine AGC showed an improved performance, including spectral signature. This study improves crown-based biomass estimations for areas where unmanned aerial vehicle or height data are not available and validates at the individual tree level using solely satellite imagery.
Ultrashort Isolated Attosecond Pulse Generation with 750-nm Free-Carrier Envelope Phase Near-Infrared Pulses
Authors: Wang Xiaowei , Xiao Fan , Wang Jiacan , Wang Li , Zhang Bin , Liu Jinlei , Zhao Jing , Zhao Zengxiu
Published: November 2024

Ultrashort laser pulses can serve as fast probes to record instant events. The isolated attosecond pulses (IAPs) generated from high-order harmonic generation (HHG) have been shortened down to about 2 atomic units in time, empowering us to study quantum behaviors of electrons in atoms, molecules, and solids with unprecedented time resolution. Following the cutoff energy law of HHG, the shortest IAP reported so far is driven with short-wavelength infrared (SWIR) pulses, which require additional broadband frequency conversion techniques and raise the bar for attosecond researches. Here, we show that with few-cycle near-infrared (NIR) laser pulses, IAP with pulse duration of 51 ± 4 as is generated during 1-fs linear polarization gate formed by generalized double optical gating (GDOG) technique. The characterization is done with attosecond streak camera, and phase reconstruction is performed with quick phase retrieval by omega oscillation filtering (qPROOF). Furthermore, we show that the IAP generation favors certain carrier envelope phases (CEPs) in the narrow gate, i.e., IAP is only efficiently produced for certain CEPs, which eliminates the requirement of CEP stabilization. The demonstrated scheme for IAP generation in principle has much higher conversion efficiency than the long-wave driver scheme according to the wavelength scaling law of HHG. Our work suggests an alternative way to generate ultrashort IAPs by applying GDOG on few-cycle free-CEP NIR driving pulses, and is thereby of great importance to facilitate the development of attosecond science and technology.
Analysis of the Role of SMEs in territorial development: case of the municipality of Akbou in Algeria
Authors: Ziane Lakhdar , Boukrif Moussa
Published: November 2024

This article examines the interaction between small and medium enterprises (SMEs) and territorial development in Akbou, Algeria, within the context of economic decentralization. Through a mixed-method approach, combining questionnaires, interviews, document analysis, and field observations, the study explores the role of SMEs in the local economy, as well as the challenges they face, such as access to financing and administrative complexity. Although rooted in local dynamics, Akbou's SMEs actively contribute to job creation, innovation, and strengthening social bonds. Cooperation between SMEs, local authorities, and support institutions is essential for overcoming obstacles and improving competitiveness. Recommendations include facilitating access to financing, promoting training, and modernizing infrastructure. These strategies could optimize the contribution of SMEs to territorial development, creating a resilient and inclusive economic ecosystem for the region.
What is a House? Exploring the Relationship between Housing and Economic Development
Authors: Enajero Samuel E.
Published: November 2024

The debate on the hypothesis that massive housing construction is the starting point of economic development has been ongoing since the end of World War II. Proponents of this hypothesis believe that housing serves asan impetus for economic development, and there is practical evidence to support this view. Opponents, however, state that housing is not a cause but a consequence of development. This latter group, in line with mainstream economic models, considers housing as a private consumer good, such as automobile, clothing, food and furniture. While the supply of housing entails enormous economies of scale, the consumption gives rise to interdependence costs. To internalize these costs, economic goods associated with interdependence costs require group or political consideration. Thus, it becomes inappropriate to model a house as a consumer good. The purpose of this article is to show that physical structure alone does not constitute a house. Private and public goods, complementary to housing, which lead to scale economies and elimination of interdependence costs excluded from relevant housing models, produce inadequate definition of a house. If these public goods complementary to housing are the stimuli needed for sustainable economic development and growth, then the debate should be about the definition of a house-is a house an economic consumer product or a political good?
Mapping Waste Generation and Economic Growth: Insights from Input-output Analysis in Malta
Authors: Ian P. Cassar, , Fenech, Margaret Camilleri
Published: November 2024

The search for an economy that is not riddled with externalities is an ongoing one. However, to reach this objective, policy making must shift its focus from the end of pipe solutions and obtain a deeper understanding of the connection that economic development and growth holds with environmental degradation. This study focuses on the connection that the economy holds with waste generation and via the application of the Waste Input Output model, it puts forward estimates illustrating how a €1-million injection in final demand impacts total waste generation, considering, both direct and indirect production and waste generation effects. The research is based on the Maltese Islands and uses 2015 as a base year. This is in view that the most recent input- output tables published by the national statistics office are built on this year. Results note that the waste generated by the construction industry remains by far the largest with 1,535.07 tonnes generated for every €1 million. Other concerning figures arise from the health and social work and agricultural sectors which result in 523.33 and 135.57 tonnes of waste respectively when there is an injection of 1 million euros.
Создание и функционирование пенитенциарной системы на территории Калининградской области в 1945–1949 гг.
Authors: А.С. Ченцов
Published: November 2024

В статье рассмотрены вопросы создания и функционирования пенитенциарной системы на территории Калининградской области в период интеграции региона в состав Советского Союза. Основные внимание уделено деятельности исправительно-трудовых колоний и отдельных лагерных пунктов, контингент которых активно использовался на восстановительных и строительных работах различных хозяйственных органов. Впервые в оборот введены документы, касающиеся вопросов агентурно-оперативной работы среди контингента учреждений пенитенциарной системы, позволяющие оценить ее действенность в пресечении негативных явлений в исправительно-трудовых учреждениях, а также в деятельности оперативных органов МВД Калининградской области.

The article examines the issues of the creation and functioning of the penitentiary system in the Kaliningrad region during the period of the region's integration into the Soviet Union. The main attention is paid to the activities of correctional labor colonies and individual camp points, the contingent of which was actively used in the restoration and construction work of various economic bodies. For the first time, documents concerning the issues of intelligence and operational work among the contingent of penitentiary institutions have been introduced into circulation, allowing us to assess its effectiveness in preventing negative phenomena in correctional labor institutions, as well as in the activities of the operational bodies of the Ministry of Internal Affairs of the Kaliningrad Region.
El delta del Nilo y las interacciones interregionales en el IV milenio a.C.
Authors: Daizo Belén
Published: November 2024

El objetivo de este trabajo es analizar y reinterpretar el papel del delta del Nilo en el marco de las dinámicas interregionales de interacción durante el IV milenio a.C. Estas interacciones contribuyeron al desarrollo social y económico de las comunidades del delta y al proceso más amplio de formación del Estado egipcio. Se argumentará que, lejos de ser una región marginal, el delta del Nilo fue un espacio dinámico donde se produjeron intercambios culturales significativos y se desarrollaron innovaciones tecnológicas que aportaron a la complejidad de la estructura social. Este análisis desafía las teorías tradicionales y promueve una comprensión integradora mediante el estudio de evidencias arqueológicas que revelan una red activa y compleja de conexiones con el Alto Egipto, el Sinaí y el Levante meridional. En este sentido, el análisis de sitios clave como Maadi, Buto, Kafr Hassan Dawood y Minshat Abu Omar proporcionará una comprensión más amplia de la complejidad de las interacciones interregionales y del papel del delta en el Período Predinástico egipcio.
FAKTOR – FAKTOR YANG MEMPENGARUHI PENGGUNAAN SISTEM INFORMASI AKUNTANSI
Authors: Hanastuti Anisha Rahma , Srimindarti Ceacilia
Published: November 2024

The objective of this research is to analysis the influence of top management support and formalization of development of systems information on using accounting information systems. Population in this study are 46 of Hospitality Service Company in Semarang City. The respondents are the employee in Hospitality Service Company that work in accounting and finance department. The sampling method use convenience sampling methods. Data analysis that used for this research is structural test using SmartPLS. The result of this research found that top management support has positif effect on use of accounting information systems. However formalization of development of systems information has not effect on use of accounting information systems.
PENGARUH GOOD CORPORATE GOVERNANCE TERHADAP KINERJA KEUANGAN PERUSAHAAN MANUFAKTUR YANG TERDAFTAR DI BEI
Authors: Nugroho Susilo Dwi , Jayanti Fitri Dwi
Published: November 2024

Penelitian ini menguji pengaruh good corporate governance yang direpresentasikan oleh gender dan age diversity dewan direksi, ukuran dewan komisaris, dan frekuensi rapat dewan direksi terhadap kinerja keuangan perusahaan yang dihitung dengan ROE (Return on Assets). Sampel penelitian ini berjumlah 62 perusahaan manufaktur yang terdaftar di BEI tahun 2020-2022 yang diperoleh melalui teknik purposive sampling. Penelitian ini menggunakan metode analisis regresi berganda. Hasil penelitian menunjukkan bahwa gender diversity dewan direksi berpengaruh positif dan signifikan terhadap kinerja keuangan, age diversity dewan direksi berpengaruh positif dan signifikan terhadap kinerja keuangan, ukuran dewan komisaris berpengaruh positif dan signifikan terhadap kinerja keuangan, frekuensi rapat dewan direksi berpengaruh positif dan signifikan terhadap kinerja keuangan.
DAMPAK PENGUMUMAN PANDEMI COVID 19 DI INDONESIA TERHADAP KINERJA IHSG DAN HARGA SAHAM BUMN BIDANG KONSTRUKSI DI BURSA EFEK INDONESIA
Authors: Tuasikal Moh. Irfan , Susianti Susianti
Published: November 2024

Kajian ini bertujuan untuk mengetahui dampak pengumuman pandemi covid 19 di Indonesia. Sebuah peristiwa yang berpengaruh besar dalam kehidupan manusia, yang berpengaruh juga dari sisi sosial ekonomi. Bursa Efek Indonesia di mana banyak perusahaan listing merupakan suatu institusi yang terpengaruh dengan keadaaan penyebaran virus corona. Pengaruh tersebut diketahui dengan adanya kecenderungan penurunan IHSG di akhir tahun 2019. Karena kecenderungan bahwa covid ini menyebar secara masif, maka kajian ini mengkaji dan membandingkan dampak pada IHSG sebelum dan sesudah pengumuman pandemi covid 19 di Indonesia. Selanjutnya juga dikaji dampaknya pada perusahaan BUMN bidang konstruksi yang ada di Bursa Efek Indonesia. Hasilnya bahwa pengumuman terkait cobid 19 di Indonesia tersebut memberikan dampak pada penurunan IHSG dan harga saham BUMN Karya yang ada.
PENGARUH PENERIMAAN PAJAK DAERAH DAN PENERIMAAN RETRIBUSI DAERAH TERHADAP BELANJA DAERAH
Authors: Sholeman Muhammad , Yanti Rizky Febri , Waruwu Aurelia Siska Yanti , Manalu Simon Patar Rizki , Pakpahan Sevalina
Published: November 2024

The purpose of this study was to determine the effect of local tax revenue and local retribution on local expenditure. The correlational method was used in this study. Multiple linear regression analysis was used as a data analysis technique in this study. Conclusions that can be drawn from this study: 1) local tax separately affects local expenditure; 2) local retribution separately does not affect local expenditure; 3) local tax and local retribution simultaneously affect local expenditure. To increase the capacity of local expenditure through local taxes and retribution, the following should be done: 1) expand the capacity of the local economy that can be taxed; 2) develop the capacity of MSMEs to contribute to generating local retribution; 3) balance the growth of local taxes with the growth of local retribution through the development of local economic capacity in order to increase the capacity of local spending.
Development of hybrid bonding using area-selective passivation layer deposition technology on various substrates for heterogeneous integrated structure
Authors: Tsai Wen-Tzu , Hsu Mu-Ping , Chen Yi-Hsuan , Liu Yu-Lun , Huang Yuan-Chiu , Chen Kuan-Neng
Published: November 2024

An advanced area-selective deposition approach for passivation layers in Cu/SiO2 and Cu/PI hybrid bonding structures is introduced in this study to reduce costs and process complexity compared to traditional PVD passivation. This method includes ultra-thin film via plasma pretreatment, successfully depositing passivation layers with precise thickness control which the Cu atoms could successfully diffuse through. The excellent hybrid bonding quality is achieved in the deposition of passivation layers, with successful bonding observed at temperatures ranging from 250 °C to 180 °C. Area-selective deposition on copper pads as small as 3 μm achieves complete area-selectivity, highlighting its significant potential for fine-pitch hybrid bonding applications. The outstanding electrical characteristics of Cu/SiO2 and Cu/PI hybrid bonding structures confirm excellent bonding quality in this study.
PENGARUH PENEMPATAN DAN MOTIVASI TERHADAP KINERJA KARYAWAN PERUSAHAAN DI BEKASI
Authors: Hidayat Wastam Wahyu
Published: November 2024

Penelitian ini bertujuan untuk mengetahui pengaruh penempatan dan motivasi terhadap kinerja karyawan pada Perusahaan di Bekasi. Penelitian ini dilakukan pada karyawan perusahaan di Bekasi dengan melibatkan  sampel sebanyak 55 orang. Alat analisa data yang di gunakan adalah dengan SPSS (Statistical Package for the Social Sciences)-25.Hasil penelitian menunjukan bahwa  Penempatan dan Motivasi berpengaruh secara parsial maupun secara simultan  terhadap Kinerja pegawai Perusahaan di Bekasi. Hasil  R square Menunjukan  sebesar 0,885 atau 88,5%,  berarti bahwa sebesar 88,5% Kinerja karyawan  Perusahaan di Bekasi  yang terjadi dapat dijelaskan dengan menggunakan variabel Penempatan dan Motivasi, sedangkan sisanya yaitu 11,5% dapat dijelaskan oleh faktor faktor penyebab lain.
PENGARUH STRES KERJA DAN KEPUASAN KERJA TERHADAP KINERJA MELALUI LOYALITAS KARYAWAN PADA PT. JASA RAHARJA CABANG KEPULAUAN RIAU
Authors: Nur Akmal , Razak Mashur , Sujatmiko Sujatmiko
Published: November 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis pengaruh stres kerja dan kepuasan kerja terhadap kinerja kinerja karyawan melalui loyalitas karyawan. Alat analisis yang digunakan dalam penelitian ini adalah SEM-PLS3, sedangkan populasi dalam penelitian ini adalah seluruh Karyawan PT. Jasa Raharja Cabang Kepulauan Riau dan mitra dari sebanyak 65 karyawan sampel adalah semua populasi. Hasil analisis menunjukkan bahwa kepuasan kerja tidak berpengaruh terhadap kinerja karyawan, kepuasan kerja berpengaruh positif terhadap loyalitas karyawan, loyalitas karyawan berpengaruh positif terhadap  kinerja karyawan, stres kerja berpengaruh positif  terhadap kinerja karyawan, stres kerja tidak berpengaruh terhadap loyalitas karyawan, kepuasan kerja melalui loyalitas karyawan berpengaruh positif terhadap kinerja karyawan serta stres kerja melalui loyalitas karyawan tidak berpengaruh terhadap kinerja karyawan .
PENGARUH BUDAYA AKHLAK TERHADAP KINERJA PEGAWAI MELALUI EMPLOYEE ENGAGEMENT PADA PT. JASA RAHARJA CABANG MALUKU
Authors: Harahap Muhammad Nur , Daga Rosnaini , Anshar Muhammad Ashari
Published: November 2024

Penelitian ini bertujuan (1) Untuk mengetahui dan menganalisis pengaruh budaya AKHLAK terhadap Kinerja Pegawai pada PT. Jasa Raharja Cabang Maluku. (2)Untuk mengetahui dan menganalisis pengaruh budaya AKHLAK terhadap employee engagement pada PT. Jasa Raharja Cabang Maluku. (3) Untuk mengetahui dan menganalisis pengaruh pengaruh employee engagement terhadap kinerja pegawai pada PT. Jasa Raharja Cabang Maluku. (4) Untuk mengetahui dan menganalisis pengaruh berpengaruh terhadap kinerja pegawai melalui employee engagement pada PT. Jasa Raharja Cabang Maluku. Alat analisis yang digunakan dalam penelitian ini adalah SEM-PLS3, sedangkan Populasi dalam penelitian ini adalah Populasi dalam penelitian ini adalah seluruh Karyawan PT. Jasa Raharja Cabang Maluku dan mitra dari sebanyak 50 pegawai dan sampel adalah semua populasi. Hasil analisis menunjukkan bahwa (1) (Employee engagement berpengaruh positif terhadap kinerja pegawai pada PT. Jasa Raharja  Cabang Maluku. (2) Budaya akhlak berpengaruh positif terhadap kinerja pegawai pada PT. Jasa Raharja  Cabang Maluku. (3) Budaya akhlak berpengaruh positif terhadap employee engagement pada PT. Jasa Raharja  Cabang Maluku. (4) Penerapan budaya akhlak melalui employee engagement berpengaruh positif terhadap kinerja pegawai pada PT. Jasa Raharja  Cabang Maluku
PENGARUH KUALITAS PELAYANAN, HARGA DAN BIAYA TERHADAP LOYALITAS MELALUI KEPUASAN NASABAH KREDIT PADA BANK DANAMON SULAMPUA
Authors: Winarto Chiau , Daga Rosnaini , Samad Abdul
Published: November 2024

Penelitian ini bertujuan untuk mengetahui dan menganalisis  pengaruh  kualitas  pelayanan, harga dan biaya terhadap loyalitas melalui kepuasan nasabah  kredit pada Bank Danamon Sulampua.Penelitian ini menggunakan metode deskriptif kuantitatif dengan menggunakan aplikasi SmartPLS 4.10 dalam proses pengolahan data selama periode penelitian. Populasi dalam penelitian ini adalah nasabah Bank Danamon Sulampua dan sampel dalam penelitian ini menggunakan metode sampel purposive sampling. Metode analisis dalam penelitian ini menggunakan Analisis Path, Uji Goodness-of Fit Test dan Pengujian Hipotesis.Hasil penelitian ini menunjukkan bahwa secara parsial 1) Kualitas pelayanan berpengaruh positif dan signifikan terhadap loyalitas nasabah Bank Danamon Sulampua, 2) Harga berpengaruh positif namun tidak signifikan terhadap loyalitas nasabah Bank Danamon Sulampua, 3) Biaya berpengaruh positif namun tidak signifikan terhadap loyalitas nasabah Bank Danamon Sulampua, 4) Kualitas pelayanan berpengaruh positif dan signifikan terhadap kepuasan nasabah Bank Danamon Sulampua, 5) Harga berpengaruh positif dan signifikan terhadap kepuasan nasabah Bank Danamon Sulampua, 6) Biaya berpengaruh positif dan signifikan terhadap kepuasan nasabah Bank Danamon Sulampua, 7) Kepuasan nasabah berpengaruh positif dan signifikan terhadap loyalitas nasabah Bank Danamon Sulampua, 8) Kualitas pelayanan berpengaruh positif dan signifikan terhadap loyalitas nasabah melalui kepuasan nasabah Bank Danamon Sulampua, 9) Harga berpengaruh positif dan signifikan terhadap loyalitas nasabah melalui kepuasan nasabah Bank Danamon Sulampua, dan 10) Biaya berpengaruh positif dan signifikan terhadap loyalitas nasabah melalui kepuasan nasabah Bank Danamon Sulampua
PENGARUH LINGKUNGAN KERJA, BUDAYA ORGANISASI DAN PENDIDIKAN TERHADAP KINERJA KARYAWAN DENGAN KOMITMEN ORGANISASI SEBAGAI VARIABEL MEDIASI PADA PEGAWAI PDAM TIRTA REMU SORONG PAPUA BARAT
Authors: Sunatar Bambang , Ahriani Andi
Published: November 2024

Sumber daya manusia merupakan unsur yang sangat penting di dalam organisasi karena sumber daya manusia memiliki peran kunci dalam menentukan kelancaran kegiatan organisasi dan keberlangsungan hidup organisasi. Perubahan lingkungan yang semakin mengglobal menuntut pihak organisasi untuk memiliki sumber daya manusia yang berkualitas, perubahan lingkungan yang terjadi ini mengarah pada pentingnya sumber daya manusia sebagai sumber keunggulan bersaing bagi organisasi. Tujuan dari penelitian ini untuk mengetahui hasil pengaruh  lingkungan kerja, budaya organisasi, pendidikan terhadap komitmen organisasi, dan mengetahui hasil pengaruh lingkungan kerja, budaya organisasi, pendidikan, komitmen organisasi terhadap kinerja karyawan. Penelitian ini dilakukan pada karyawan yang bekerja pada PDAM Tirta Remu Sorong Papua Barat. Teknik sampling adalah Slovin, sehingga di peroleh sebenyak 93 responden karyawan yang bekerja pada PDAM Tirta Remu Sorong Papua Barat. Teknik analisis penelitian adalah Analisis PLS-SEM. Sehingga diperoleh hasil bahwa lingkungan kerja, budaya organisasi Pendidikan memiliki pengaruh positif terhadap komitmen organisasi. budaya organisasi, Pendidikan, komitmen organisasi memiliki pengaruh positif terhadap kinerja karyawan, sedangkan lingkungan kerja tidak berpengaruh terhadap kinerja karyawan. secara tidak langsung lingkungan kerja, budaya organisasi, dan pendidikan terhadap kinerja karyawan melalui komitmen organisasi secara positif dan signifikan
PERAN KOMPENSASI, MOTIVASI DAN STRES KERJA TERHADAP KINERJA TENAGA KESEHATAN PADA RUMAH SAKIT DI KOTA MAKASSAR
Authors: Gunawan Hendra
Published: November 2024

Penelitian ini bertujuan untuk menganalisis pengaruh kompensasi, motivasi, dan stres kerja terhadap kinerja tenaga kesehatan di rumah sakit di Kota Makassar. Metode yang digunakan adalah kuantitatif  dengan pendekatan Structural Equation Modeling - Partial Least Squares (SEM-PLS) untuk menguji hubungan antar variabel. Data dikumpulkan melalui kuesioner terstruktur yang disebarkan kepada tenaga kesehatan, dengan total sampel yang diambil secara purposif.Hasil penelitian menunjukkan bahwa kompensasi, motivasi, dan stres kerja masing-masing memiliki pengaruh positif dan signifikan terhadap kinerja tenaga kesehatan. Kompensasi  yang memadai dan adil meningkatkan produktivitas tenaga kesehatan. Motivasi, baik intrinsik maupun ekstrinsik, mendorong tenaga kesehatan untuk memberikan pelayanan yang optimal. Selain itu, stres kerja dalam batas tertentu dapat meningkatkan efisiensi kinerja, tetapi perlu dikelola dengan baik agar tidak menurunkan produktivitas.Model penelitian ini mampu menjelaskan 78,5% variabilitas kinerja tenaga kesehatan (R² = 0,785), dan memiliki relevansi prediktif yang kuat (Q² = 0,581). Implikasi praktis dari penelitian ini adalah pentingnya manajemen rumah sakit untuk memberikan kompensasi yang adil, meningkatkan motivasi, dan melakukan pemantauan serta pengelolaan stres secara efektif. Temuan ini diharapkan dapat membantu rumah sakit di Kota Makassar dan institusi kesehatan lainnya dalam mengembangkan kebijakan manajemen sumber daya manusia untuk meningkatkan kinerja dan kualitas layanan
Incidence and Risk Factors of Chronic Pain after Cesarean Delivery- An Observational Study
Authors: Halim Dr. Tanzila , Khatun Dr. Hasina , Ferdous Dr. Bilkis , Ara Dr. Rowson , Khatun Dr. Khodeza
Published: November 2024

Background: Chronic pain following cesarean delivery (CD) is a recognized postoperative complication affecting a notable proportion of women. The incidence and risk factors for chronic post-surgical pain in CD are influenced by physical, psychological, and procedural variables. Aim of the study: The aim of this study was to evaluate the incidence and risk factors of chronic pain after cesarean delivery. Methods: This cross-sectional observational study was conducted in Department of Obstetrics and Gynaecology, Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from March 2023 to February 2024. Total 100 women undergoing cesarean delivery were included in this study. Result: In our study, majority (46%) were in the age group of 18-24 years. About 53% participants with chronic pain reported preoperative anxiety (p = 0.015), and 47% reported depression compared to 9% in the non-chronic pain group (p < 0.0001). Chronic pain was present in 50% of anemic and 83% of malnourished participants (p < 0.0001 for both). Spinal anesthesia was associated with higher chronic pain (83%) than epidural (p < 0.0001). Surgery duration, intraoperative excessive bleeding (OR = 4.9, p < 0.0001) and wound infection (OR = 3.8, p < 0.0001) as well as postoperative wound infection (OR = 3.8; p < 0.0001) and excessive physical activity (OR = 4.2; p < 0.0001) also significantly increased chronic pain risk. Conclusion: This study highlights a significant incidence of chronic pain after cesarean delivery, with socioeconomic status, psychological factors, anemia, malnutrition, intraoperative complications, postoperative wound infection and excessive physical activity as strong predictors.
Explorando a geração de imagens anatômicas por diferentes inteligências artificiais
Authors: Alves Oliveira Pereira Juliana , Dantas Maia Forte Lucas
Published: November 2024

Objetivo: Este estudo explora a capacidade das plataformas de inteligências artificais generativas em gerar imagens realistas do joelho, uma região anatômica complexa e amplamente estudada pelos profissionais de saúde. Método: Utilizando ferramentas como Midjourney, Leonardo.Ai e BlueWillow, foram feitos experimentos com o prompt "Realistic image of the ligaments of a knee dissected for study". Resultado: Apesar dos avanços notáveis, especialmente com o Midjourney, as imagens geradas carecem de detalhes anatômicos precisos, muitas vezes representando estruturas de forma equivocada. Conclusão: Ainda existem limitações significativas que comprometem a geração de imagens por inteligências artificiais para o aprendizado da anatomia.
Exercícios Físicos No Período Gestacional: Aspectos Indicativos E Contra Indicativos Da Prática E Normativos
Authors: Raimundo de Almeida Lima Jefferson , Paiva Átila Castro , Oliveira Alcileia Pena de , Castro Juliana Brandão Pinto de , Leiziane Silva e Souza Leiziane Silva e Souza , Nascimento Yanka Magalhães do , Oliveira Euza Karla Nazaré de Brito , Cavalcante Ronaldo Macena , Aguiar Ana Cláudia Rolim de São Paulo , Silva Matheus Henrique Prado , Medeiros Lucas Soares de , Santos Aurélio Dias , Chaves Fabiola Gondim Medeiros
Published: November 2024

O Exercício Físico (EF) refere-se a atividades físicas planejadas, organizadas e repetitivas com o objetivo de melhorar a saúde e a capacidade funcional das pessoas, facilitando suas tarefas diárias. Os estudos da literatura revelam que o EF pode desenvolver benefícios significativos para gestantes, com poucos profissionais de saúde recomendando a interrupção dos exercícios para aquelas que já possuem um hábito saudável de prática física. Este estudo este trabalho busca esclarecer questões sobre diretrizes, protocolos e recomendações para a prescrição de treinamento de força durante a gestação Para tanto, foi realizada uma revisão de literatura de artigos científicos sobre o assunto, destacando as principais recomendações para a atividade física com as gestantes, no pós parto, frequência, intensidade, tempo, exercícios aeróbicos e resistidos. Os achados indicam que o EF traz vantagens tanto para a saúde da gestante quanto para sua rotina diária. As evidências sugerem que a prática de EF durante a gestação, quando supervisionada por um profissional de Educação Física.
Desmistificando o Infarto Agudo do Miocárdio: Estratégias de Prevenção e Intervenção
Authors: Nobrega Silva Layra , Mendes de Oliveira Nunes Matheus , Fortuna Kalil de Faria Ivan Aurélio , Soares Alcantara da Silva Rubia , Teles Tomaz Mariana , Hildefonso Diogo Mariano , Bezerra Veras Filho Augusto César , Salvador Medeiros Fernanda , Rocha Guimarães Kaique Wbiratan
Published: November 2024

Este artigo visa analisar as principais estratégias de prevenção e intervenção no Infarto Agudo do Miocárdio, utilizando a base de dados PubMed com os termos "Infarto Agudo do Miocárdio", "Prevenção" e "Tratamento farmacológico". Os resultados demonstram que o Infarto Agudo do Miocárdio continua sendo uma das principais causas de morte no mundo, mas a implementação de estratégias de prevenção e intervenção tem mostrado resultados promissores na redução da mortalidade e na melhoria da qualidade de vida dos pacientes. As abordagens mais eficazes incluem a adoção de hábitos saudáveis, o rastreamento precoce dos fatores de risco e a intervenção rápida em casos de infarto. A educação em saúde, junto a políticas públicas que incentivem o monitoramento constante dos fatores de risco e a oferta de tratamentos adequados, é essencial para promover a saúde cardiovascular e reduzir a carga global dessa doença. Entretanto, é necessário avançar ainda mais na conscientização da população e na capacitação dos profissionais de saúde, especialmente em regiões com menor acesso a recursos e serviços de saúde. A continuidade das pesquisas sobre novas terapias e métodos de prevenção também se faz essencial, visando não apenas a eficácia dos tratamentos, mas a melhoria do acompanhamento dos pacientes a longo prazo. Somente com uma abordagem integrada e contínua será possível reduzir os impactos do Infarto Agudo do Miocárdio e melhorar o prognóstico dos pacientes afetados por essa condição.
KINERJA PASAR EKSPOR KARET NEGARA ITRC (International Tripartite Rubber Council) DI PASAR INTERNASIONAL: PENDEKATAN ALMOST IDEAL DEMAND SYSTEM (AIDS)
Authors: Adetya Aulia
Published: November 2024

Indonesia, sebagai produsen karet global, memiliki peluang besar untuk diversifikasi di luar sekadar ekspor karet. Dinamika perdagangan internasional semakin meningkatkan peluang ekspor antarnegara. Setiap negara harus mampu bertahan dan menghadap persaingan di pasar internasional dengan memiliki keunggulan pada produk atau komoditas tertentu. Penelitian ini bertujuan untuk (1) menganalsis pangsa pasar ekspor karet Indonesia dan Thailand di pasar internasional, (2) menganalisis posisi pasar ekspor karet Indonesia dan Thailand di pasar internasional menggunakan pendekatan AIDS. Penelitian ini menggunakan data sekunder dalam bentuk time series bulanan dari tahun 2012 -2023. Sumber data berasal dari World Trade Organization dengan kode HS 400121 (Smoked sheets of natural rubber) yang dianalisis menggunakan pendekatan Almost Ideal Demand System (AIDS). Hasil penelitian menunjukkan bahwa nilai rata-rata pangsa pasar ekspor karet Indonesia dan Thailand di pasar internasional sebesar 3 persen dan 36 persen. Nilai elastisitas pengeluaran (expenditure) ekspor karet Indonesia bernilai positif, hal tersebut menunjukkan bahwa karet Indonesia termasuk kedalam barang normal dan bersifat inelastis. Elastisitas harga sendiri (uncompensated) pada Indonesia bersifat elastis, sedangkan Thailand bersifat inelastic dengan hubungan negatif. Elastisitas harga silang (compensated) manunjukkan antara Indonesia dengan Thailand bernilai negatif dan tersebut menunjukkan adanya hubungan komplementer, artinya apabila harga karet Thailand meningkat maka akan menurunkan pangsa pasar ekspor Indonesia, namun bersifat inelastis.
ANALISIS MINAT GENERASI MUDA DALAM BERWIRAUSAHA BIDANG PERTANIAN JAGUNG DI DESA JAJAR KECAMATAN GANDUSARI KABUPATEN TULUNGAGUNG
Authors: Diah Lestari Mufida , Solikah Umi , Ulaela Sajali Chusnatul
Published: November 2024

Generasi muda adalah generasi penerus bangsa yang menjadi tumpuan pengembangan perekonomian Indonesia. Kondisi geografis yang sangat strategis untuk mengembangkan usaha dalam bidang pertanian salah satunya pada pertanian jagung. Jagung menjadi sala satu komoditas pangan setelah beras yang dapat memberikan hasil produksi yang besar di Desa Jajar Kecamatan Gandusari Kecamatan Tulungagung. Melihat dari potensi besar salam berwirasuaha bidang pertanian jagung tentunya agar dapat tetap berkembang dan memiliki peningkatan pada produksi jagung maka perlu peran serta generasi muda untuk bisa mengambangkan pertanian jagung. Generasi muda diharapkan menjadi agen perubahan dalam sistem pertanian yang lebih maju dan berkembang, namun saat ini minimnya minat generasi muda dalam bidang pertanian tentunya menjadi salah satu kendala untuk menumbuhkan munat generasi muda berwirausaha di bidang pertanian. Peneliti dalam hal ini melakukan penelitian di Desa Jajar Kecamatan Gandusari Kabupaten Trenggalek dengan tujuan mengali minat generasi muda dalam berwirausaha di bidang pertanian jagung. Metode yang digunakan penelitian ini adalah penelitian kualitatif dengan informannya adalah pemuda-pemudi yang ada didaerah penelitian. Hasil dari penelitian terdapat beberap faktor penentu minat dari generasi muda di daerah penelitian terhadap minat mereka dalam beruwirausaha dibidang pertanian diantaranya adalah minimnya minat pemuda-pemudi dalam berwirausaha dibidang pertanian, minimnya pengetahuan dalam bidang budidaya pertanian jagung, high risk karena mereka berasumsi bahwa pertanian adalah salah satu jenis usaha yang memiliki resiko tingi karena sangat bergantung pada cuaca, iklim, bencana dan lain sebagainya, minimnya penghasilan dari bertani sehingga pemuda-pemudi tidak berminat dan faktor lainnya adalah modal yang mereka miliki sangat minim, seperti tidak memiliki modal untuk memulai usaha di bidang pertanian. Dari penelitian tersebut peneliti memberikan Kesimpulan bahwa banyak dari generasi muda yang enggan berwirausaha dibidang pertanian sehingga pertanian hingga saat ini kurang dapat berkembang dengan pesat karena masih dodominasi dengan metode-metode yang tradisional.
Presentación atípica de enfermedad de Hansen, a propósito de un caso
Authors: Castillo Quino Rubén , Vallejo Castro Efraín , Quiñones López Arturo , Canelas Urey Heidy
Published: November 2024

Introducción. La lepra enfermedad infecciosa crónica, denominada también enfermedad de Hansen, es causada por Mycobacterium leprae, un bacilo alcohol-acidorresistente. Afecta principalmente a la piel, los nervios periféricos, la mucosa de las vías respiratorias altas, los ojos y otras estructuras. Caso Clínico. Mujer de 58 años de edad, en marzo de 2018 consulta por un cuadro clínico progresivo que data de 8 años aproximadamente caracterizado por: hipoestesia, dolor de tipo neuropático de curso progresivo en extremidad superior izquierda, que no cede con los analgésicos menores, debiendo hacer uso de opioides; Pérdida gradual de los movimientos, calambre, retracción cutánea, atrofia muscular de las extremidades superiores e inferiores y pérdida de fuerza muscular progresiva, con hiporreflexia y disestesia, dificultad para la prensión y movimientos finos impidiendo su actividad laboral, refiere residencia temporal en áreas endémicas para la enfermedad de Hansen y Tuberculosis en Bolivia. Discusión y conclusiones. El caso particularmente raro y diferente, siendo que se ha observado la presentación ósea sugerente de espondilitis tuberculosa en columna vertebral en 2 sitios anatómicos C2-C3 y L5-S1 con afectación funcional motora y sensitiva correspondientemente. El polimorfismo clínico del caso descrito evidencia la presentación no usual en tejido óseo y afectación nerviosa, la histopatología fue compatible con Lepra Tuberculoide, La neuropatía leprótica, responsable de la aparición de: Síndromes dolorosos tan severos en la paciente. Este caso además se traduce en un problema para la salud Pública ocupacional, por la complejidad del diagnóstico y las barreras al momento de la notificación.
Identitas Budaya Arab pada Rumah Masyarakat Arab Hadrami di Tanah Abang Jakarta (Studi Kasus Keluarga Al-Barqi)
Authors: Priyoyudanto Febri , Abdullah Amani
Published: November 2024

The spatial design and application of ornaments in the houses of the Hadrami Arab community in Indonesia has its uniqueness. The distinctiveness features a combination or adaptation of cultures, resulting in a unique design character. This represents the cultural identity that is still maintained by the Hadrami Arab community in Tanah Abang, Central Jakarta. The type of research in this study is descriptive qualitative. The direct observation method is used to identify problems in the form of the application of space design and Arabic-style ornaments that are still maintained in the Hadrami Arab community house in Tanah Abang, Central Jakarta in the Hadrami Al-Barqi family. The findings of this research reveal the application of Arabic-style ornaments with Arabesque characteristics and also the application of space design with Arabic styles both classical and modern. This research is expected to contribute to public understanding of Hadrami Arab culture as a peranakan Arab community that also contributes to Indonesia's multicultural cultural repertoire.

Keywords – Hadhrami Arabs, Cultural Identity, Spatial Design, Ornament.
Aprendizaje Basado en Problemas: una alternativa para fortalecer la competencia de indagación en docentes de Ciencias Naturales
Authors: Pacheco Diana Milena , Hernández Barbosa Rubinsten
Published: November 2024

Se describe el trabajo de investigación que tuvo como propósito favorecer procesos de formación continua en los docentes de Ciencias Naturales de una institución educativa, específicamente, en lo concerniente a la competencia de indagación, aspecto esencial para el desarrollo del pensamiento científico y crítico, la creatividad e innovación, la formulación de preguntas y el aprendizaje significativo. Se diseñó e implementó una propuesta de formación fundamentada teóricamente en el Aprendizaje Basado en Problemas, una estrategia que fomenta la solución de problemas reales y contextuales, generación de hipótesis, trabajo colaborativo y autonomía en el aprendizaje, entre otros aspectos. El trabajo se desarrolló en tres fases, se enmarcó desde un enfoque cualitativo y un paradigma sociocrítico que centró la atención en la acción pedagógica, lo que permitió a los profesores de ciencias naturales reflexionar sobre su práctica docente, las necesidades de los estudiantes y los planes de mejoramiento institucional. Se aplicaron diversas técnicas e instrumentos para recolectar y analizar la información como cuestionario y diario de campo. Para el análisis de contenido de la información se usó N-Vivo. Desde un trabajo cooperativo, propio de las comunidades de práctica y aprendizaje, el modelo de intervención con los docentes favoreció la apropiación conceptual, generó intercambio de ideas y conocimientos sobre la estrategia, tomando de base la interdisciplinariedad. Dado el éxito de la propuesta, la propusieron como un espacio de formación continua y la incluyeron como parte del plan de mejoramiento institucional.
El mito del cambio y la crisis permanente en educación
Authors: Castillo-Armijo Pablo
Published: November 2024

La teoría y práctica en educación es un campo de estudio que lleva más de un siglo de avance y acumulación de conocimiento, que de manera helicoidal (como un resorte) nos entrega nuevos postulados, paradigmas e ideas para superar las diversas crisis y coyunturas en el mundo de la pedagogía.