bluuebunny/crossref_metadata_2025 huggingface dataset:
Draft Genome Sequence of a Campylobacter coli WL22 Isolate Possessing
erm
(B) with
gyrA
Mutations, Isolated from Poultry in China
Authors: Wu Lin , Zhai Xia , Jin Yaojian , Lou Hongqiang , Huang Junwei
Published: May 2021

Campylobacter coli
is a major foodborne pathogen worldwide that causes campylobacteriosis cases in humans and is an emerging threat in developing countries. The rapid dissemination of the macrolide resistance gene
erm
(B) poses a significant threat to the clinical therapy of campylobacteriosis. Here, we report the draft genome sequences of one
Campylobacter coli
strain possessing
erm
(B), isolated from the cecal contents of poultry in Jinhua, China.

Campylobacter coli
is a common foodborne pathogenic bacterium that causes bacterial gastroenteritis in humans (
1
). Poultry are believed to be the most important sources of
C. coli
human infections. The rapid dissemination of the macrolide resistance gene
erm
(B) will likely compromise the efficacy of macrolides as the treatment of choice for campylobacteriosis (
2
).We describe here the draft genome sequences of one
Campylobacter coli
WL22 strain (GONG3) possessing
erm
(B) with
gyrA
mutations.
Complete Genome Sequences of Pseudomonas atacamensis Strain SM1 and Pseudomonas toyotomiensis Strain SM2, Isolated from the Date Palm Rhizosphere
Authors: Elmahi Yassine , Alshamsi Mohammed Saeed , Sudalaimuthuasari Naganeeswaran , Kundu Biduth , AlMaskari Raja S. , Hazzouri Khaled M. , Chandran Subha , Malik Shahana Sehar , Mundra Sunil , Amiri Khaled M. A.
Published: May 2021

Here, we announce the complete genome sequences of two phosphate-solubilizing rhizobacteria,
Pseudomonas atacamensis
strain SM1 (genome size, ∼5.9 Mb) and
Pseudomonas toyotomiensis
strain SM2 (genome size, ∼5.2 Mb), isolated from the rhizosphere of date palms growing in the oasis agroecosystem of the United Arab Emirates (UAE).
Draft Genome Sequences of Three Multidrug-Resistant Staphylococcus spp. Isolated from Hospital Wastewater in Malaysia
Authors: Ahmad Sabri Nurul Syazwani , Mohd Zulkeflle Siti Norayuni , Yusof Nurtasbiyah , Md Akhir Fazrena Nadia , Othman Nor’azizi , Zakaria Zuriati , Hara Hirofumi
Published: May 2021

Staphylococcus
spp. are Gram-positive bacteria that reside within the normal microbiota of humans and animals but pose a health threat as reservoirs of antimicrobial resistance genes. Here, we present the draft genome sequences of three
Staphylococcus
sp. strains isolated from hospital wastewater in Malaysia that demonstrated resistance to multiple antibiotics.
Administration of parenteral nutrition during therapeutic hypothermia: a population level observational study using routinely collected data held in the National Neonatal Research Database
Authors: Gale Chris , Jeyakumaran Dusha , Longford Nicholas , Battersby Cheryl , Ojha Shalini , Oughham Kayleigh , Dorling Jon
Published: May 2021

Background

Parenteral nutrition is commonly administered during therapeutic hypothermia. Randomised trials in critically ill children indicate that parenteral nutrition may be harmful.

Objective

To examine the association between parenteral nutrition during therapeutic hypothermia and clinically important outcomes.

Design

Retrospective, population-based cohort study using the National Neonatal Research Database; propensity scores were used to create matched groups for comparison.

Setting

National Health Service neonatal units in England, Scotland and Wales.

Participants

6030 term and near-term babies, born 1/1/2010 and 31/12/2017, who received therapeutic hypothermia; 2480 babies in the matched analysis.

Exposure

We compared babies that received any parenteral nutrition during therapeutic hypothermia with babies that did not.

Main outcome measures

Primary outcome: blood culture confirmed late-onset infection; secondary outcomes: treatment for late onset infection, necrotising enterocolitis, survival, length of stay, measures of breast feeding, hypoglycaemia, central line days, time to full enteral feeds, discharge weight.

Results

1475/6030 babies (25%) received parenteral nutrition. In comparative matched analyses, the rate of culture positive late onset infection was higher in babies that received parenteral nutrition (0.3% vs 0.9%; difference 0.6; 95% CI 0.1, 1.2; p=0.03), but treatment for presumed infection was not (difference 0.8%, 95% CI −2.1 to 3.6, p=0.61). Survival was higher in babies that received parenteral nutrition (93.1% vs 90.0%; rate difference 3.1, 95% CI 1.5, 4.7; p<0.001).

Conclusions

Receipt of parenteral nutrition during therapeutic hypothermia is associated with higher late-onset infection but lower mortality. This finding may be explained by residual confounding. Research should address the risks and benefits of parenteral nutrition in this population.
Cervical adenitis caused byStaphylococcus aureusin a newborn
Authors: Pinho Crisbety , Serra de Almeida Nuno , Tiago Joaquim , Ratola Ana
Published: May 2021

Cervical acute lymphadenitis is rarely described in neonates. We present the case of a 12-day-old preterm, fed by nasogastric tube, who presented a tender erythematous submandibular swelling. Laboratory data showed neutrophilia and an elevation of C reactive protein and procalcitonin. Ultrasound ﬁndings suggested cellulitis and adenitis with abscess. The culture of the drainage material identified methicillin-sensitiveStaphylococcus aureus. With the administration of the right antibiotic treatment, a good clinical outcome was observed.
Endometriosis in the tract of transvaginal ovum pick up, a rare and late complication of in vitro fertilisation
Authors: Deshpande Swarika Hemant , Deshpande Swanit Hemant , Deshpande Priti Hemant , Parasnis Amit
Published: May 2021

Endometriosis is a common and painful condition. We present a case of a 33-year-old woman who had delivered triplets after in vitro fertilisation (IVF) for male factor infertility. She did not have any clinical features suggestive of endometriosis before the IVF treatment. The patient presented 7 years after conception, with premensural and postmenstrual abdominal pain and intense pain on defecation. The patient was diagnosed to have endometriosis in the tract of transvaginal ovum pick up in the right pouch of Douglas and right distal uterosacral ligament. The patient underwent excision of a nodule of endometriosis. The patient is asymptomatic 1 month after surgery. Histopathology analysis revealed features suggestive of endometriosis. The needle ovum pick up tract must have implanted the endometriotic tissue near the pararectal tissue. This is an unreported and late complication of IVF treatment.
Platypnoea–orthodeoxia syndrome in COVID-19
Authors: Aayilliath K Adarsh , Singh Komal , Ray Animesh , Wig Naveet
Published: May 2021

Platypnoea–orthodeoxia syndrome (POS) is a rare entity characterised by respiratory distress and/or hypoxia developing in the sitting/upright posture, which is relieved in the supine posture. It is caused by cardiac, pulmonary and non-cardiopulmonary diseases. COVID-19 can have varying respiratory manifestations including acute respiratory distress syndrome (ARDS) and sequelae-like pulmonary fibrosis. POS has been rarely reported in patients with COVID-19. Here we report a case of POS in a patient recovering from severe COVID-19 ARDS. As he was gradually mobilised after his improvement, he had worsening dyspnoea in the sitting position with significant relief on assuming a supine posture. He was diagnosed with POS after ruling out other causes of POS. He was treated with oxygen support in upright posture and chest physiotherapy was continued, to which he showed improvement. POS is a rare manifestation of COVID-19 which needs awareness as it can be diagnosed easily and can respond to continued supportive care.
Adipophilin expression in skin lesions with clear cell histology
Authors: Li Feng-Zeng , Ye Qian , Ran Li-Wei , Fang Sheng
Published: May 2021

Aims

Clear cells formed due to depositions of glycogen or lipids in the cytoplasm commonly occur in various tissues. Adipophilin (ADP), a lipid regulatory protein, is closely related to lipid droplets. This study aims to examine adipophilin expression in clear cells of various skin lesions.

Methods

ADP expression was examined using immunohistochemistry in 108 sections from 15 skin lesion types with clear cell histology, namely, sebaceoma (n=16), sebaceous adenoma (n=3), sebaceous carcinoma (n=12), xanthomata cutis (n=10), xanthogranuloma (n=8), Paget’s disease (n=10), Bowen disease (n=10), hidradenoma (n=9), atypical lipoma (n=5), superficial lipomatous nevus (n=5), metastatic renal cell carcinoma (n=5), squamous cell carcinoma (n=4), seborrheic keratosis (n=4), dermatofibroma (n=4) and clear cell sarcoma (n=3).

Results

ADP was not expressed in Bowen disease, hidradenoma or seborrheic keratosis. Four expression patterns, foamy, reticular, granular and punctate, were summarised based on their expression in clear cells. Different expression patterns were related to tissue origin and differentiation degree. Foamy expression was commonly observed in lesions with mature sebaceous glands and xanthomas; reticular expression in adipocytes; granular expression in xanthoma, xanthogranuloma and metastatic renal carcinoma and punctate expression in sebaceoma, sebaceous carcinoma, Paget’s disease, squamous cell carcinoma and clear cell sarcoma. Furthermore, stronger staining with focal vesicular labelling was noted in sebaceoma than in sebaceous carcinoma. Characteristic labelling was noted, including the circular distribution in Touton giant cells of xanthogranulomas and focal distribution in the clear cells along the edge of necrotic tissue in clear cell sarcoma.

Conclusions

ADP is useful in identifying intracytoplasmic lipids and can be used to diagnose skin lesions with clear cell histology, especially in some lesions with characteristic labelling.
Evaluation of an open-source machine-learning tool to quantify bone marrow plasma cells
Authors: Baranova Katherina , Tran Christopher , Plantinga Paul , Sangle Nikhil
Published: May 2021

Aims

The objective of this study was to develop and validate an open-source digital pathology tool, QuPath, to automatically quantify CD138-positive bone marrow plasma cells (BMPCs).

Methods

We analysed CD138-scanned slides in QuPath. In the initial training phase, manual positive and negative cell counts were performed in representative areas of 10 bone marrow biopsies. Values from the manual counts were used to fine-tune parameters to detect BMPCs, using the positive cell detection and neural network (NN) classifier functions. In the testing phase, whole-slide images in an additional 40 cases were analysed. Output from the NN classifier was compared with two pathologist’s estimates of BMPC percentage.

Results

The training set included manual counts ranging from 2403 to 17 287 cells per slide, with a median BMPC percentage of 13% (range: 3.1%–80.7%). In the testing phase, the quantification of plasma cells by image analysis correlated well with manual counting, particularly when restricted to BMPC percentages of <30% (Pearson’s r=0.96, p<0.001). Concordance between the NN classifier and the pathologist whole-slide estimates was similarly good, with an intraclass correlation of 0.83 and a weighted kappa for the NN classifier of 0.80 with the first rater and 0.90 with the second rater. This was similar to the weighted kappa between the two human raters (0.81).

Conclusions

This represents a validated digital pathology tool to assist in automatically and reliably counting BMPC percentage on CD138-stained slides with an acceptable error rate.
Adequacy of small biopsy and cytology specimens for comprehensive genomic profiling of patients with non-small-cell lung cancer to determine eligibility for immune checkpoint inhibitor and targeted therapy
Authors: Faber Erin , Grosu Horiana , Sabir Sharjeel , San Lucas Francis Anthony , Barkoh Bedia A , Bassett Roland L , Luthra Rajyalakshmi , Stewart John , Roy-Chowdhuri Sinchita
Published: May 2021

Aims

In advanced-stage non-small-cell lung cancer (NSCLC), incomplete genotyping for guideline-recommended genomic biomarkers poses a significant challenge to making informed and timely clinical decisions. We report our institution’s experience in assessing the adequacy of small specimens for comprehensive genomic profiling for guideline-recommended lung cancer biomarker testing.

Methods

We performed a retrospective evaluation of all image-guided procedures for NSCLC performed in our institution between October 2016 and July 2018, including core needle biopsy (CNB) and fine-needle aspiration (FNA) in patients who had undergone genomic profiling for lung cancer. Lung cancer biomarker adequacy, defined as successful testing of guideline-recommended biomarkers including, epidermal growth factor receptor (EGFR); serine/threonine protein kinase B-Raf (BRAF); anaplastic lymphoma kinase (ALK); proto-oncogene tyrosine protein kinase ROS (ROS1); Rearranged during Transfection (RET); Tyrosine protein kinase Met (MET); and programmed cell death ligand 1 (PD-L1), was evaluated.

Results

A total of 865 cases were evaluated in this study, 785 of which included testing of all lung cancer biomarkers. Lung tissue was adequate for biomarker testing in 84% of cases; this rate increased to 87% when biomarker testing was combined with concurrently acquired FNA or CNB specimens. Biomarker testing success correlated strongly with DNA concentration (p<0.0001) and the use of 22G needles in endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) procedures (p=0.0035). Biomarker testing of CNB specimens showed a significantly higher success rate than did biomarker testing of cytology FNA specimens (p=0.0005). The adequacy of EBUS-TBNA samples was not significantly different from that of the transthoracic needle aspiration samples (p=0.40). Variables such as age, gender, lesion size, site, diagnosis and number of needle passes showed no significant correlation with success rates in lung cancer biomarker testing.

Conclusion

The growing numbers of therapeutic biomarkers in NSCLC requires judicious triage of limited-volume tissue from small specimens. Our study showed that thoracic small tissue specimens can be used successfully to provide prognostic and predictive information for the current guideline-recommended biomarkers for NSCLC in most cases.
Can the Calcium-Regulating Hormones Counteract the Detrimental Impact of Pro-Inflammatory Damage-Associated Molecular Patterns in the Development of Heart Failure?
Authors: Adamyan Satenik H , Harutyunyan Knarik R , Abrahamyan Hermine T , Khudaverdyan Drastamat N , Mkrtchian Souren , Ter-Markosyan Anna S
Published: May 2021

Growing evidence suggests an important role of the inflammatory component in heart failure (HF). Recent developments in this field indicate an ambiguous role that innate immunity plays in immune-driven HF. Damaged or stressed cells, cardiomyocytes, in particular, emit damage-associated molecular patterns (DAMPs) including HMGB1, S100 A8/A9, HSP70, and other molecules, unfolding paracrine mechanisms that induce an innate immune response. Designed as an adaptive, regenerative reaction, innate immunity may nevertheless become overactivated and thus contribute to the development of HF by altering the pacemaker rhythm, contraction, and electromechanical coupling, presumably by impairing the calcium homeostasis. The current review will explore a hypothesis of the involvement of the calcium-regulating hormones such as parathyroid hormone and parathyroid hormone-related protein in counteracting the detrimental impact of the excess of DAMPs and therefore improving the functional cardiac characteristics especially in the acute phase of the disease.
Ultrasound-guided regional anesthesia in the emergency department: an argument for multidisciplinary collaboration to increase access while maintaining quality and standards
Authors: Stone Alexander , Goldsmith Andrew J , Pozner Charles N , Vlassakov Kamen
Published: May 2021

The practice of ultrasound-guided regional anesthesia (UGRA) by emergency medicine physicians in the emergency department (ED) is increasing. The need for effective alternatives to opioid analgesia in the acute care setting likely exceeds the current capacity of UGRA-trained anesthesia teams. In this daring discourse, we outline several matters of relevance to be considered as protocols are put into place to facilitate the practice of UGRA by emergency medicine physicians in the ED. There are opportunities for collaboration between anesthesiology and emergency medicine societies in guideline development as well as educational resources. The sustained interest in UGRA shown by many emergency medicine physicians should be viewed open-mindedly by anesthesiologists. Failure to collaborate on local and national scales could lead to delays in the development and implementation of patient-centered, safe procedural care, and limit patient access to the benefits of regional anesthesia.
Obturator nerve block does not provide analgesic benefits in total hip arthroplasty under multimodal analgesic regimen: a randomized controlled trial
Authors: Marty Philippe , Chassery Clement , Rontes Olivier , Vuillaume Corine , Basset Bertrand , Merouani Mehdi , Marquis Constance , Delussy Anne , Delbos Marie-Claude , Ferre Fabrice , Bataille Benoit , Joshi Girish , Delbos Alain
Published: May 2021

Background and objectives

Although regional analgesia is considered an important component of optimal pain management, use of peripheral nerve blocks for total hip arthroplasty remains controversial. Since the obturator nerve innervates the anteromedial part of the joint capsule, we hypothesized that an obturator nerve block would decrease the opioid consumption after total hip arthroplasty.

Methods

In this single center, prospective, triple blinded study, we randomly allocated 60 patients undergoing total hip arthroplasty under opioid-sparing total intravenous general anesthesia to a preoperative obturator nerve block or a sham block (placebo group) using 20 mL of ropivacaine 0.2% or saline, respectively. All patients received a multimodal analgesic regimen with non-opioid analgesics including periarticular local infiltration analgesia. The primary outcome was the intravenous opioid consumption in the post-anesthesia care unit.

Results

Median (IQR) intravenous oxycodone consumption in the post-anesthesia care unit was 4 (2, 7.5) mg in the obturator nerve block group and 3 (0, 4) mg in the placebo group (p=0.05). There were no differences in pain scores between groups in the first 24 hours except at arrival on the surgical ward with significant higher pain scores in the placebo group (p=0.03). The ability to stand up and walk within 24 hours was comparable between groups as was the time to first walk (180 (90, 720) vs 240 (120, 780) min for the obturator nerve block and placebo groups, respectively; p=0.62).

Conclusions

Obturator nerve block did not improve postoperative opioid consumption after total hip arthroplasty performed under general anesthesia with a multimodal analgesic regimen.

Trial registration number

NCT04085640.
Phosphorus ligand-free Suzuki–Miyaura reactions in the presence of ABTS at room temperature in water
Authors: Lan Yingdong , Yuan Jianjun , Yang Qin , Peng Yiyuan
Published: May 2021

A catalytic system for a phosphorus ligand-free Suzuki–Miyaura reaction in water at room temperature was disclosed. Ammonium 2,2′-azino-bis(3-ethylbenzthiazoline-6-sulfonate) (ABTS) was an efficient promoter and acted both as a ligand and as a surfactant for the synthesis of biaryl compounds via the Suzuki–Miyaura reaction in water. The targeted biaryl architectures were achieved under mild conditions with high efficiency and good functional group tolerance.
CMB imprints of non-canonical anisotropic inflation
Authors: Do Tuan Q. , Kao W. F. , Lin Ing-Chen
Published: May 2021

Effect of non-canonical scalar fields on the CMB imprints of the anisotropic inflation will be discussed in details in this paper. In particular, we are able to obtain the general formalism of the angular power spectra in the scalar perturbations, tensor perturbations, cross-correlations, and linear polarization in the context of the anisotropic inflation model involving non-canonical scalar fields. Furthermore, some significant numerical spectra will be plotted using the most recent data of Planck as well as the BICEP2 and Keck array. As a result, we find a very interesting point that the TT spectra induced by the tensor perturbations as well as by the linear polarization will increase when the speed of sound decreases.
Painlevé analysis, Bäcklund transformations and traveling-wave solutions for a (3 + 1)-dimensional generalized Kadomtsev–Petviashvili equation in a fluid
Authors: Ma Yong-Xin , Tian Bo , Qu Qi-Xing , Yang Dan-Yu , Chen Yu-Qi
Published: May 2021

Fluids are seen in such disciplines as atmospheric science, oceanography and astrophysics. In this paper, we investigate a (3 + 1)-dimensional generalized Kadomtsev–Petviashvili equation in a fluid. On the basis of the Painlevé analysis, we find that the equation is Painlevé integrable under a certain constraint. Through the truncated Painlevé expansion, we give an auto-Bäcklund transformation. By virtue of the Hirota method, we derive a bilinear auto-Bäcklund transformation. Via the polynomial-expansion method, traveling-wave solutions are obtained. We observe that the amplitude of a traveling wave remains invariant during the propagation. We graphically demonstrate that the amplitude of the traveling-wave is affected by the coefficients corresponding to the dispersion and nonlinearity effects, while other coefficients have no influence on the traveling-wave amplitude, which represent the perturbed effects and disturbed wave velocity effects.
Exploration of Word Width and Cluster Size Effects on Tree-Based Embedded FPGA Using an Automation Framework
Authors: Saidi Hajer , Turki Mariem , Marrakchi Zied , Ahmed Hela Ben , Obeid Abdulfattah , Abid Mohamed
Published: May 2021

This paper introduces a novel framework that automates and accelerates the development of embedded Field Programmable Gate Arrays (eFPGAs). The proposed solution is considered as the first environment for tree-based eFPGA implementation including software, hardware and loader. The developed framework allows users to generate eFPGA architecture in the form of hardware description language using Physical Design Flow (PDF) tool. It is a powerful tool that can produce a wide variety of designs ranging from small eFPGA to complex eFPGA. The bit file description of practical application is done in parallel, simultaneously and rapidly by the suggested Computer Aided Design (CAD) tools. The Loader, called Multi-Level Loader (MLL), is also provided to inject the bits into the corresponding SRAMs. Our framework is widely explored by modifying the data width. This research proves that data width equal to 17 has the best trade-off between performance, area and static power. However, it is penalized for buses having data length greater than 32. The experimentation demonstrates that a data width equal to 12 is the best for a 32-bit bus. Automation and significant acceleration of the eFPGA development cycle are also achieved in this study. A set of bench-marking applications with various multi-use purposes is mapped. The experimental results show the efficiency and flexibility of the proposed framework.
Discrete Chaotification of a Modulated Logistic System
Authors: Ashish  , Cao Jinde , Chugh Renu
Published: May 2021

In the last few decades, the discrete chaotification of difference equations has gained the considerable attention of academicians and scholars due to its tremendous applications in many branches of science, such as cryptography, traffic control models, secure communications, weather forecasting and engineering. In this article, a modulated logistic system is studied and superior chaos is reported through period-doubling bifurcation, period-three orbit and Lyapunov exponent properties. It is interesting to see that the modulated system admits the superiority in chaos due to the presence of an extra degree of freedom of an ordered parameter [Formula: see text]. Analytical as well as numerical simulations are demonstrated to examine the period-doubling and Lyapunov exponent properties for some particular values of parameter [Formula: see text]. Moreover, it is speculated that the superiority in chaos may be used in chaos-based cryptography, in the future.
A New Memristive Chaotic System with a Plane and Two Lines of Equilibria
Authors: Wang Zhen , Khalaf Abdul Jalil M. , Jafari Sajad , Panahi Shirin , Li Chunbiao , Hussain Iqtadar
Published: May 2021

A new 4D memristive chaotic system with an infinite number of equilibria is proposed via exhaustive computer search. Interestingly, such a new memristive system has a plane of equilibria and two other lines of equilibria. Lyapunov exponent and bifurcation analysis show that this system has chaotic solutions with coexisting attractors. The basins of attraction of the coexisting attractors show chaos, stable fixed-points, and unbounded solutions. Furthermore, the 2D parameter space of the system is explored to find the optimum values of the parameters using the ALO (Ant Lion Optimizer) optimization algorithm.
The Number of Limit Cycles Bifurcating from a Degenerate Center of Piecewise Smooth Differential Systems
Authors: Wei Lijun , Xu Yancong , Zhang Xiang
Published: May 2021

For two families of planar piecewise smooth polynomial differential systems, whose unperturbed system has a degenerate center at the origin, we study the biggest lower bound for the maximum number of limit cycles bifurcating from the periodic orbits of the center. These results are extensions of the known ones on unperturbed nondegenerate [Formula: see text]-center, derived from a nonsmooth harmonic oscillator model, to degenerate [Formula: see text]-center. Our study involves some new computational treatments. The main tools are the generalized polar coordinate change and the generalized Lyapunov polar coordinate change together with an averaging theory for one-dimensional piecewise smooth differential equations. Finally, we present two Maple programs for computing the averaging functions and consequently the biggest lower bound on the maximum number of limit cycles of degenerate [Formula: see text]-center under general polynomial perturbations of degree [Formula: see text].
Effect of Time-Reversed Chaotic Sequences on the Performance of 2T2R-IDCSK System
Authors: Que Doan Thi , Quyen Nguyen Xuan , Hoang Thang Manh , Volos Christos , Berber Stevan
Published: May 2021

In this paper, a chaotic communication system based on the combination of Improved–Differential chaos-shift keying (IDCSK) scheme and [Formula: see text] MIMO technique (2T2R), namely 2T2R-IDCSK, is investigated. We point out that there are differences in correlation characteristics between the conventional and time-reversed chaotic sequences. From this aspect, bit-error-rate (BER) performance of the system over an additive white Gaussian noise (AWGN) channel is analyzed taking into account the correlation effect of time-reversed chaotic sequences. BER expressions are verified by Monte-Carlo simulation. The obtained results prove that the 2T2R-IDCSK system performs worse under the correlation effect, however still dramatically outperforms the conventional [Formula: see text] MIMO-DCSK system.
Jacobi Stability Analysis and the Onset of Chaos in a Two-Degree-of-Freedom Mechanical System
Authors: Wang Fanrui , Liu Ting , Kuznetsov Nikolay V. , Wei Zhouchao
Published: May 2021

In this paper, the Jacobi stability of a two-degree-of-freedom mechanical system is studied by the innovative application of KCC-theory, namely differential geometric methods. We discuss the Jacobi stability of two equilibria and a periodic orbit by constructing geometric invariants. Both the regions of Jacobi stability and Lyapunov stability are presented to show the difference. We draw the phase portraits of the deviation vector near two equilibria under specific parameter values and initial conditions, and point out the sensitivity of deviation vector to initial conditions. In addition, the corresponding instability exponent and curvature are applicable for predicting the onset of chaos, which help us to detect chaotic behaviors quantitatively.
Poincaré Bifurcations Induced by a Nonregular Point on the Discontinuity Boundary in a Family of Planar Piecewise Linear Differential Systems
Authors: Huan Song-Mei , Wu Tian-Tian , Wang Lei
Published: May 2021

For a family of planar piecewise linear differential systems with two zones both having virtual foci, we investigate the appearance of limit cycles bifurcated from a global center (i.e. Poincaré bifurcations of limit cycles) when the discontinuity boundary is perturbed by the appearance of a nonregular point. Precisely, when the discontinuity boundary, which is a straight line, becomes two rays starting from the same point, we prove that accompanied by the birth of a limit cycle, the center either disappears or becomes local. So, our main results contain some sufficient conditions satisfied by the system parameters that guarantee the appearance of a limit cycle surrounding a period annulus. Moreover, our results provide a new method to design such a system having any number of limit cycles.
Solving Bi-Level Multi-Objective Transportation Problem under Fuzziness
Authors: Mardanya Dharmadas , Maity Gurupada , Roy Sankar Kumar
Published: May 2021

This paper describes a study on bi-level multi-objective transportation problem in fuzzy environment. To alleviate a difficulty of transporting goods within nodes for long distances, we venture to formulate a transportation problem using bi-level criteria. Again, in this paper, we incorporate the real-life uncertain situation in bi-level transportation system through fuzziness. It produces a new class of transportation problem, namely fuzzy bi-level multi-objective transportation problem (FBMOTP). We solve FBMOTP with and without priority of the 1st level of transportation problem (TP) using the Vogal Approximation Method (VAM) which are called respectively Approach 1 and Approach 2. A special emphasis of this paper is to introduce a new approach namely Approach 3 for solving the FBMOTP in addition to the considered two approaches. In this regard, we incorporate an algorithm for Approach 3 to find compromise solution of the FBMOTP using VAM. Thereafter, the proposed algorithm is illustrated to show the usefulness by taking a numerical example. A comparative analysis with the existing studies is provided to understand the effectiveness of the proposed methodology. At last, conclusions are described with the lines of future study of the paper.
MULTI-OBJECTIVE OPTIMIZATION OF EDM PROCESS PARAMETERS USING RSM-BASED GRA AND TOPSIS METHOD FOR GRADE 6 TITANIUM ALLOY
Authors: BHAUMIK MUNMUN , MAITY KALIPADA , MOHAPATRA KASINATH DAS
Published: May 2021

In this study, an attempt has been taken to find out the appropriate optimal parameter setting that will provide the best quality product depending on experimental data during Electro Discharge Machining (EDM) of Titanium grade 6 alloy with the help of brass electrode and to compare the optimized results achieved from two optimization techniques. For this study, Face Centered Central Composite Design- (FCCCD) based Response Surface Methodology (RSM) coupled with Technique for order of preference by similarity to ideal solution (TOPSIS) and Grey Relational Analysis (GRA) has been applied to optimize the process parameters i.e. gap voltage ([Formula: see text], peak current ([Formula: see text], pulse on time ([Formula: see text], and duty cycle ([Formula: see text]). Radial overcut (ROC), surface roughness ([Formula: see text], material removal rate (MRR) and tool wear rate (TWR) are selected as output performance characteristics. To find out the significant process parameters, Analysis of variance (ANOVA) test has been performed at 95% confidence level. For validation of the study, confirmation experiments have been performed at optimal parameters setting which show the enhancement of Relative Closeness Coefficient ([Formula: see text] up to 0.144082 using TOPSIS and Grey Relational Grade (GRG) up to 0.198014 using GRA, respectively.
Lumbopelvic sagittal standing posture associations with anthropometry, physical activity levels and trunk muscle endurance in healthy adults
Authors: Koumantakis George A. , Malkotsis Antonios , Pappas Stefanos , Manetta Maria , Anastopoulos Timotheos , Kakouris Apollon , Kiourtsidakis Eleutherios
Published: May 2021

Background: Various factors, inherited and acquired, are associated with habitual spinal postures.

Objective: The purpose of this study was to identify the relationships between trunk muscle endurance, anthropometry and physical activity/inactivity and the sagittal standing lumbopelvic posture in pain-free young participants.

Methods: In this study, 112 healthy young adults (66 females), with median (IQR) age of 20 years (18.2–22 years), without low back pain, injury or trauma were included. Lumbar curve (LC) and sacral slope (SS) angles were measured in standing with a mobile phone application (iHandy level). Anthropometric, physical activity/inactivity levels (leisure-time sport involvement and sitting hours/day) and abdominal (plank prone bridge test) and paraspinal (Sorensen test) isometric muscle endurance measures were collected.

Results: LC and SS angles correlated significantly ([Formula: see text], [Formula: see text]). Statistically significant differences for both LC ([Formula: see text]) and SS ([Formula: see text]) angles were identified between the male and female participants. A significant negative correlation was identified between the abdominal endurance time and LC ([Formula: see text], [Formula: see text]); however, the power of this result (56%) was not sufficiently high. The correlation between abdominal endurance and SS was non-significant ([Formula: see text], [Formula: see text]). In addition, no significant associations were identified between either of the sagittal lumbopelvic angles (LC–SS) in standing and the participants’ body mass index (BMI), paraspinal endurance, leisure-time sport involvement or sitting hours/day.

Conclusion: The potential role of preventive exercise in controlling lumbar lordosis via enhancement of the abdominal muscle endurance characteristics requires further confirmation. A subsequent study, performed in a larger population of more diverse occupational involvement and leisure-time physical activity levels, is proposed.
Synthesis, structure, electronic characterization, and halogenation of gold(III) phlorin complexes
Authors: Pistner Allen J. , Martin Maxwell I. , Yap Glenn P.A. , Rosenthal Joel
Published: May 2021

The metalation chemistry of the phlorin, which is a non-aromatic tetrapyrrole macrocycle containing a single sp3-hybridized meso-carbon has remained underdeveloped, as compared to that of more traditional tetrapyrroles such as porphyrins, corroles and phthalocyanines. There have been few prior efforts to prepare metallophlorins, and those that have been reported have relied on either reduction or nucleophilic attack of parent metalloporphyrins, rather than direct metalation of freebase phlorin constructs. In this work, an alternate synthetic approach for preparation of gold(III) phlorin complexes that involves the first direct metalation of two different freebase phlorin derivatives (3H(Phl[Formula: see text] and 3H(Phl[Formula: see text] with AuBr3to produce the stable and fully isolable gold(III) phlorin complexes Au(Phl[Formula: see text] and Au(Phl[Formula: see text] is reported. The first structural characterization of a metallophlorin bearing geminal dimethyl substituents at the sp3-hybridized meso-carbon via X-ray crystallography is also reported. In addition to the preparation of Au(Phl[Formula: see text] and Au(Phl[Formula: see text], the UV-vis absorption and redox properties of these two gold(III) phlorins in comparison to those of their freebase homologues is also detailed. Notably, the metallophlorins are characterized by panchromatic absorbance profiles and intense and broad bands that span the long-visible and into the near-IR regions, as well as two fully reversible oxidation and reduction waves as probed by cyclic voltammetry. Finally, the chlorination of Au(Phl[Formula: see text] using PhI(Cl[Formula: see text] was probed and it was found that this regioslective reaction generates monochlorinated (Au(Phl[Formula: see text]Cl)) and dichlorinated (Au(Phl[Formula: see text]Cl[Formula: see text] products, which were both structurally characterized by X-ray crystallography.
Domination Numbers of Inverse Fuzzy Graphs with Application in Decision-Making Problems
Authors: Almallah R. , Borzooei R. A. , Jun Y. B.
Published: May 2021

Recently, in Borzooei et al. [Inverse fuzzy graphs with applications, to appear in New Mathematics and Natural Computation], we defined the concept of inverse fuzzy graph as a generalization of graph, which is able to answer some problems that graph theory and fuzzy graph theory cannot explain. Now, in this paper, we define the notions of dominating set, domination number and different kinds of dominating sets like strong, weak, total, independent and inverse dominating sets with their domination numbers in inverse fuzzy graphs. Then, we investigate the relations among different kinds of dominating numbers. Finally, we give an application in decision making for service buildings.
Comments to 𝒩-cubic sets with an NC-decision making problem
Authors: Karazma F. , Kologani M. Aaly , Borzooei R. A. , Jun Y. B.
Published: May 2021

In this paper, we want to investigate some theorems about [Formula: see text]-cubic sets in [Sh. Rashid, M. Gulistan, Y. B. Jun, S. Khan and S. Kadry, [Formula: see text]-cubic sets and aggregation operators, J. Intell. Fuzzy Syst. 37(4) (2019) 5009–5023] and while correcting these theorems, we get new results in this issue and at the end we present an application regarding decision making. First, by using some examples, we show that the conditions of some theorems in above-mentioned paper are not true in general and then we attempt to correct these theorems and proofs. Moreover, we discuss some new related results in [Formula: see text]-cubic sets. Finally, we discuss the score function and [Formula: see text]-cubic weighted average operator of [Formula: see text]-cubic sets for application in physical and different engineering regions.
China’s Urbanization Strategy and Policy During the 14th Five-Year Plan Period
Authors: WEI Houkai , LI Le , NIAN Meng
Published: May 2021

During the 13th Five-Year Plan period, China’s urbanization construction has obtained remarkable achievements. Its urbanization continues to advance rapidly. The gap between different regions is constantly narrowed. City clusters have become the strategic core areas to promote urbanization and economic development. Currently, the key issue in China’s urbanization is not about the level or speed, but the quality. Tough challenges faced by China in its urbanization include: (1) granting permanent urban residency to people originally from rural areas (citizenization) is severely lagging-behind; (2) the key links in integrated urban–rural development system and mechanism are blocked and (3) the resources and environment costs in advancing urbanization are excessively high, etc. During the 14th Five-Year Plan period, China’s urbanization will continue to advance rapidly, but the speed will further slow down. By 2025, China’s urbanization rate is expected to reach about 65.5%, among which the eastern, central, western and northeastern regions will reach 73.0%, 63.1%, 61.2% and 66.7%, respectively. To this end, China’s urbanization should be people-centered and led by high-quality integrated urban and rural development; thus, the urbanization quality can be improved in an all-round way. It should be a path of high-quality urbanization with Chinese characteristics featuring moderate and reasonable advancing speed, effectively improved quality in citizenization, balanced and orderly urbanization pattern, deeply integrated urban and rural development, and green, healthy and sustainable development. In terms of specific measures, the government should strengthen the leading, demonstrating and radiating role of central cities and promote the formation of four-tier central city system, namely, the global central cities, national central cities, regional central cities and local central cities; plan and build 34 high-end metropolitan areas at the national level, making them the core areas of advancing new-type urbanization in the new era; accelerate the process of establishing cities, encourage the transformation of large towns into cities, and strictly control the transformation of counties into urban districts; implement differentiated policies for expanding, stable and shrinking cities and towns, respectively; connect the channels between homesteads exiting the market and collective construction land for commercial use entering the market.
MatOrtho Proximal Interphalangeal Joint Arthroplasty via Lateral Approach: Minimum 2-Year Follow-Up
Authors: Fowler Andrew , Arshad Mohammed Shoaib , Talwalkar Sumedh , Trail Ian
Published: May 2021

Background: The MatOrtho implant is a cementless, mobile-bearing surface arthroplasty with a cobalt–chromium metal-on polyethylene articulation designed to treat osteoarthritis of the PIP joint. Early results for the prosthesis inserted through a dorsal approach have demonstrated good pain relief but no significant improvement in range of motion. In an attempt to improve the range of motion the senior author has changed his surgical practice to inserting the MatOrtho implant via a lateral approach. The purpose of this study is to assess the outcome of this change of surgical technique.

Methods: Consecutive patients with osteoarthritis who underwent PIPJ replacement surgery via the lateral approach at a single institution, with a minimum follow-up period of 2 years were identified. A visual analogue score was used to assess pain. Grip strength, range of motion and functional outcomes scores were collected.

Results: A total of 46 PIP joint arthroplasties were performed in 29 patients. Ten patients were lost to follow-up resulting in 33 PIP joint arthroplasties reviewed in 19 patients. Six implants failed. The mean follow-up time at the final follow-up for the remaining 25 prosthesis was 34.2 months (range 24–52). Range of motion improved from a mean of 37.2 preoperatively to a mean of 57.9 postoperatively. This was statistically significant (p = 0.0007). There was also a significant improvement in pain and functional outcome scores but not for grip strength.

Conclusions: The MatOrtho PIPJ replacement delivers significant improvements in pain relief and functional outcome scores, as well as increased range of motion when the surgical procedure is performed through a lateral approach. There are, however, limitations to the use of this implant. Currently we do not consider this implant when there is instability or deformity of the PIP joint preoperatively.
Carpal Tunnel Surgery Using a Wireless Endoscopic Visualization Instrument: A Cadaveric Study
Authors: Liawrungrueang Wongthawat , Wongsiri Sunton , Chatpun Surapong
Published: May 2021

Background: Endoscopic carpal tunnel release is a common treatment for moderate to severe carpal tunnel syndrome. Recently there have been various new techniques which offer improved accuracy and decreased recovery time. In this study, orthopedic surgeons and biomedical engineers from the Faculty of Medicine and Faculty of Engineering, Prince of Songkla University, designed a wireless endoscopic carpal tunnel release with a single portal technique and tested the efficacy and safety of the new technique in a cadaveric study.

Methods: Ten fresh cadaveric forearms were used in the study. The surgical technique began with a surgical incision 15–20 mm above the wrist crease on the line between the middle finger and ring finger. The palmaris longus aponeurosis was retracted by Senn retractors. A visual enhancer was inserted to improve the internal visual field in order to see the flexor retinaculum clearly. The flexor retinaculum was cut distally to create an entry and the flexor retinaculum was cut by the scalpel. The flexor retinaculum length was observed until the release was completed. The median nerve was observed.

Results: Each flexor retinaculum was cut completely. All of the median nerves were carefully observed during the operation and none were injured. This technique showed the effectiveness and safety of minimally invasive carpal tunnel surgery.

Conclusions: The study found that the new device using this technique is effective for carpal tunnel syndrome (CTS) surgery in terms of minimally invasive endoscopic carpal tunnel surgery.
Constraints on duration, age and migration of the feeder systems of the Madagascan Flood Basalt Province from high-precision
40
Ar/
39
Ar chronology
Authors: Cucciniello Ciro , Morra Vincenzo , Melluso Leone , Jourdan Fred
Published: May 2021

The Late Cretaceous magmatism in Madagascar is correlated with the break-up between Madagascar and Greater India, with a presumed track of a hotspot from Madagascar towards the Marion Island and with an anoxic event in the Late Cretaceous. The lava succession and associated dyke swarms and sills of western Madagascar (Mailaka area) represent a volumetrically important area of the igneous province, where dykes with random orientation, several igneous intrusions and a flood basalt to rhyodacite sequence do occur. The magmas have a tholeiitic and weakly alkaline affinity. Using plagioclase separates, we obtained two plateau
40
Ar/
39
Ar ages, and an inverse isochron age statistically indistinguishable, ranging from 92.9 ± 3.8 to 91.2 ± 1.3 Ma (2
σ
). These ages indicate that tholeiitic and alkaline rocks were erupted in the same age span. In addition, these ages are close to the Cenomanian–Turonian (C–T; 93.9 ± 0.2 Ma) boundary and are indistinguishable from the U–Pb ages available for the capping rhyodacitic unit of the Mailaka lava succession. A filtered compilation of eight ages for northern and central-western Madagascar rocks suggests a duration for the magmatic activity in this part of Madagascar province of the order of
c.
3 Ma. If the western Madagascar magmatism is plume related, the plume head would need to have been located near the Mailaka area at
c.
93 Ma. The geochemistry of the mafic lavas and dykes of western Madagascar is barely distinguishable from mid-ocean ridge basalt (MORB), with an increasing crustal contamination towards the evolved rocks, and does not constrain input of typical components derived by plume magmatism.
Mechanisms of exercise as a preventative measure to muscle wasting
Authors: Graham Zachary A. , Lavin Kaleen M. , O’Bryan Samia M. , Thalacker-Mercer Anna E. , Buford Thomas W. , Ford Kenneth M. , Broderick Timothy J. , Bamman Marcas M.
Published: May 2021

Skeletal muscle is the most abundant tissue in healthy individuals and it has important roles in health beyond voluntary movement. The overall mass and energy requirements of skeletal muscle require it to be metabolically active and flexible to multiple energy substrates. The tissue has evolved to be largely load dependent and it readily adapts in a number of positive ways to repetitive overload, such as various forms of exercise training. However, unloading from extended bed rest and/or metabolic derangements in response to trauma, acute illness, or severe pathology, commonly results in rapid muscle wasting. Decline in muscle mass contributes to multimorbidity, reduces function, and exerts a substantial, negative impact on the quality of life. The principal mechanisms controlling muscle mass have been well described and these cellular processes are intricately regulated by exercise. Accordingly, exercise has shown great promise and efficacy in preventing or slowing muscle wasting through changes in molecular physiology, organelle function, cell signaling pathways, and epigenetic regulation. In this review, we focus on the role of exercise in altering the molecular landscape of skeletal muscle in a manner that improves or maintains its health and function in the presence of unloading or disease.

epigenetics; exercise; muscle wasting; resistance training; skeletal muscle