bluuebunny/crossref_metadata_2025 huggingface dataset:
Quantitative chemical proteomics reveals that phenethyl isothiocyanate covalently targets BID to promote apoptosis
Authors: Dong Xiaoshu , Yu Xinqian , Lu Minghao , Xu Yaxin , Zhou Liyan , Peng Tao
Published: October 2024

Naturally occurring isothiocyanates (ITCs) found in cruciferous vegetables, such as benzyl isothiocyanate (BITC), phenethyl isothiocyanate (PEITC), and sulforaphane (SFN), have attracted significant research interest for their promising anti-cancer activity in vitro and in vivo. While the induction of apoptosis is recognized to play a key role in the anti-cancer effects of ITCs, the specific protein targets and associated upstream events underlying ITC-induced apoptosis remain unknown. In this study, we present a set of chemical probes that are derived from BITC, PEITC, and SFN and equipped with bioorthogonal alkynyl handles to systematically profile the target proteins of ITCs in live cancer cells. Using a competition-based quantitative chemical proteomics approach, we identify a range of candidate target proteins of ITCs enriched in biological processes such as apoptosis. We show that BID, an apoptosis regulator of the Bcl-2 family, is covalently modified by ITCs on its N-terminal cysteines. Functional characterization demonstrates that covalent binding to N-terminal cysteines of BID by PEITC results in conformational changes of the protein and disruption of the self-inhibitory interaction between N- and C-terminal regions of BID, thus unleashing the highly active C-terminal segment to exert downstream pro-apoptotic effects. Consistently, PEITC promotes the cleavage and mitochondrial translocation of BID, leading to a strong induction of apoptosis. We further show that mutation of N-terminal cysteines impairs the N- and C-terminal interaction of BID, relieving the self-inhibition and enhancing its apoptotic activity. Overall, our chemical proteomics profiling and functional studies not only reveal BID as the principal target of PEITC in mediating upstream events for the induction of apoptosis, but also uncover a novel molecular mechanism involving N-terminal cysteines within the first helix of BID in regulating its pro-apoptotic potential.
Characterization of Y chromosome diversity in newfoundland and labrador: evidence for a structured founding population
Authors: Zurel Heather , Bhérer Claude , Batten Ryan , MacMillan Margaret E. , Demiriz Sedat , Mirhendi Sadra , Gilbert Edmund , Cavalleri Gianpiero L. , Leach Richard A. , Scott Roderick E. M. , Mugford Gerald , Randhawa Ranjit , Symington Alison L. , Stephens J. Claiborne , Phillips Michael S.
Published: October 2024

The population of Newfoundland and Labrador (NL) is largely derived from settlers who migrated primarily from England and Ireland in the 1700s–1800s. Previously described as an isolated founder population, based on historical and demographic studies, data on the genetic ancestry of this population remains fragmentary. Here we describe the largest investigation of patrilineal ancestry in NL. To determine the paternal genetic structure of the population, 1,110 Y chromosomes from an NL-based cohort were analyzed using 5,761 Y-specific SNPs. We identified 160 distinct terminal haplogroups, the majority of which (71.4%) belong to the R1b haplogroup. When compared with global reference populations, the NL population haplogroup composition and frequencies primarily resemble those observed in English and Irish ancestral source populations. There is also evidence of genetic contributions from Basque, French, Portuguese, and Spanish fishermen and early settlers who frequented NL. Interestingly, the observed population structure shows geographical and religious clustering that can be associated with the settlement of the ancestral source populations from predominantly Protestant, England, and Catholic, Ireland respectively. For example, the R1b-M222 haplogroup, seen in people of Irish descent, is found clustered in the Irish-settled Southeast region of NL. The clustering and expansion of Y haplogroups in conjunction with the geographical and religious clusters illustrate that limited subsequent in-migration, geographic isolation, and societal factors have contributed to the genetic substructure of the NL population and its designation as a founder population.
Systemic and local lipid adaptations underlie regeneration in Drosophila melanogaster and Ambystoma mexicanum
Authors: Kübler Ines C. , Kretzschmar Jenny , Arredondo-Lasso Maria Nieves , Keeley Sean D. , Rößler Luca Claudia , Ganss Katharina , Sandoval-Guzmán Tatiana , Brankatschk Marko
Published: October 2024

In regenerating tissues, synthesis and remodeling of membranes rely on lipid turnover and transport. Our study addresses lipid adaptations in intestinal regeneration of Drosophila melanogaster and limb regeneration of Ambystoma mexicanum. We found changes in lipid profiles at different locations: transport, storage organs and regenerating tissues. We demonstrate that attenuating insulin signaling, exclusively in fat storage, inhibits the regeneration-specific response in both the fat storage and the regenerating tissue in Drosophila. Furthermore, in uninjured axolotls we found sex-specific lipid profiles in both storage and circulation, while in regenerating animals these differences subside. The regenerating limb presents a unique sterol profile, albeit with no sex differences. We postulate that regeneration triggers a systemic response, where organs storing lipids play a significant role in the regulation of systemic lipid traffic. Second, that this response may be an active and well-regulated mechanism, as observed when homeostatic sex-differences disappear in regenerating salamanders.
Trace benzene capture by decoration of structural defects in metal–organic framework materials
Authors: Han Yu , Huang Wenyuan , He Meng , An Bing , Chen Yinlin , Han Xue , An Lan , Kippax-Jones Meredydd , Li Jiangnan , Yang Yuhang , Frogley Mark D. , Li Cheng , Crawshaw Danielle , Manuel Pascal , Rudić Svemir , Cheng Yongqiang , Silverwood Ian , Daemen Luke L. , Ramirez-Cuesta Anibal J. , Day Sarah J. , Thompson Stephen P. , Spencer Ben F. , Nikiel Marek , Lee Daniel , Schröder Martin , Yang Sihai
Published: October 2024

Capture of trace benzene is an important and challenging task. Metal–organic framework materials are promising sorbents for a variety of gases, but their limited capacity towards benzene at low concentration remains unresolved. Here we report the adsorption of trace benzene by decorating a structural defect in MIL-125-defect with single-atom metal centres to afford MIL-125-X (X = Mn, Fe, Co, Ni, Cu, Zn; MIL-125, Ti8O8(OH)4(BDC)6 where H2BDC is 1,4-benzenedicarboxylic acid). At 298 K, MIL-125-Zn exhibits a benzene uptake of 7.63 mmol g−1 at 1.2 mbar and 5.33 mmol g−1 at 0.12 mbar, and breakthrough experiments confirm the removal of trace benzene (from 5 to <0.5 ppm) from air (up to 111,000 min g−1 of metal–organic framework), even after exposure to moisture. The binding of benzene to the defect and open Zn(II) sites at low pressure has been visualized by diffraction, scattering and spectroscopy. This work highlights the importance of fine-tuning pore chemistry for designing adsorbents for the removal of air pollutants.
Background uncertainty does not increase risk aversion in decision making
Authors: Leder Johannes , Chapkovski Philipp , Schütz Astrid , Lauer Thomas , Gürerk Özgür
Published: October 2024

Some theories in economics and psychology propose that background uncertainty, which is uncertainty that is independent of a person’s actual decision, can alter people’s risk-taking behavior with respect to that decision. However, previous empirical research mostly relying on single experiments is inconclusive regarding the existence of this effect. Here, we systematically investigate the effect of background uncertainty on decision-making. After reviewing the literature, we argue that two types of background uncertainty should be distinguished: (a) background ambiguity, where the decision maker does not know the probability of the outcomes of the background event, and (b) background risk, where the outcome probabilities are known. We tested the hypotheses (i) that background uncertainty does affect risk-taking in the decision at hand, and (ii) the type of background uncertainty moderates that effect. In four experiments (total N =863), we induced background uncertainty (ambiguity or risk) using different methods and measured risk-taking with multiple behavioral tasks. We did not find a significant effect of background uncertainty on risk-taking behavior.
Transfer from goal-directed behavior to stimulus-response habits and its modulation by acute stress in individuals with risky gaming behavior
Authors: Schmid Anna M. , Thomas Tobias A. , Blümel Stefan , Erdal Nicolas K. , Müller Silke M. , Merz Christian J. , Wolf Oliver T. , Brand Matthias , Müller Astrid , Steins-Loeber Sabine
Published: October 2024

Habitual responses towards addiction-related cues play a relevant role in the development and maintenance of addictions. Such automatic responses may be more likely under stress, as stress has been shown to induce a shift from goal-directed to habitual behavior. The current study investigated these mechanisms in risky gaming behavior. Individuals with risky gaming behavior (n = 68), as established by a structured clinical interview, and a matched control group (n = 67) completed a Pavlovian-to-Instrumental Transfer (PIT) paradigm with gaming-related cues and rewards. After the Pavlovian training, participants underwent a stress (Trier Social Stress Test) or control condition before performing the instrumental training and the transfer phase of the PIT paradigm. To assess habitual behavior, the gaming-related rewards were devalued after half of the transfer phase. In both groups, gaming-related cues enhanced the choice of the gaming-related reward and this gaming PIT effect was reduced, however, not eliminated by the devaluation. Unexpectedly, stress did not significantly increase responding for the gaming-related reward in participants aware of the stimulus-outcome associations, however seemed to enhance habitual responding in unaware participants. Our findings underline the relevance of gaming-related cues in triggering habitual responses, which may undermine attempts to change a problematic gaming behavior.
A novel alkali and thermotolerant protease from Aeromonas spp. retrieved from wastewater
Authors: Sodagar Najmeh , Jalal Razieh , Najafi Mohsen Fathi , Bahrami Ahmad Reza
Published: October 2024

Enzymes are integral to numerous industrial processes, with a growing global demand for various enzyme types. Protease enzymes, in particular, have proven to be cost-effective, stable, and compatible alternatives to traditional chemical processes in both industrial and environmental applications. In this study, an alkaline protease-producing strain of Aeromonas spp. was isolated from a wastewater treatment plant in Iran. The protease production was confirmed by culturing the strain on casein agar medium. The bacterium was identified through morphological, biochemical, and 16 S rRNA sequencing analyses. The optimal culture medium for bacterial growth and enzyme production was obtained using peptone, salt, yeast extract, galactose, and CaCl₂ at an initial pH of 8. Maximum protease production was achieved after 20 h of incubation at 40 °C. To partially purify the enzyme, the supernatant of the bacterial culture medium was first centrifuged, and the enzyme was precipitated using ammonium sulfate, followed by dialysis. Zymography revealed the production of one type of protease during bacterial growth. The partially purified protease exhibited optimal activity at pH 8.5 and maximum stability at pH 9. The optimum temperature for maximum enzyme activity was observed at 50 °C, with 100% residual activity retained for 1 h at 0 °C. The effect of metal ions on enzyme activity was assessed, revealing that KCl induced the most significant effects (p < 0.0001) on enzyme activity. Chemical amino acid modifiers and inhibitors, such as EDTA, DEPSI, and IAA, did not exhibit significant inhibition. In contrast, PMSF and HNBB significantly (p < 0.0001) reduced enzyme activity, suggesting that the enzyme could be classified as a serine protease. The protease also demonstrated high stability in the presence of 2% SDS, showing no signs inactivation. The alkaline pH optimum, thermal stability, and resistance to SDS exhibited by the protease produced by the Aeromonas strain are particularly promising characteristics that warrant further investigation. Based on preliminary tests and the enzyme’s characteristics, this protease can be recommended for various applications, pending further studies.
Persistent defensive reactivity during extensive avoidance training as a potential mechanism for the perpetuation of safety behaviors
Authors: Franke Joscha , Melzig Christiane A. , Benke Christoph
Published: October 2024

Safety behaviors are core features of anxiety-related disorders, specifically involving behaviors that do not completely terminate aversive situations, but rather prevent the risk of the occurrence of the expected aversive outcome (US). This study aimed to examine the dynamics of defensive reactivity associated with safety behaviors, both before and after their execution, and to investigate changes in these reactions following extensive training. Twenty-four healthy participants underwent a US-avoidance task as an experimental analog to model safety behavior, requiring a button press to avoid the US without terminating the associated warning cue (CS). Two CS+ were used, with one being devalued during a devaluation procedure to assess the formation of avoidance habits. Defensive reactivity was assessed using fear-potentiated startle (FPS) and skin conductance responses (SCR). Participants showed pronounced defensive reactivity to both CS + vs. CS- before the avoidance action, which decreased upon the opportunity to avoid the US. Contrarily, after the avoidance action, a re-emergence of defensive responses was observed as indicated by FPS and increased SCR. Only one participant showed signs of avoidance habit formation. The findings reveal a re-emergence of defensive reactivity following safety behaviors challenging the prevailing belief that relief is the primary sustaining factor of safety behavior.
A student trained convolutional neural network competing with a commercial AI software and experts in organ at risk segmentation
Authors: Bürkle Sophia L. , Kuhn Dejan , Fechter Tobias , Radicioni Gianluca , Hartong Nanna , Freitag Martin T. , Qiu Xuefeng , Karagiannis Efstratios , Grosu Anca-Ligia , Baltas Dimos , Zamboglou Constantinos , Spohn Simon K. B.
Published: October 2024

This retrospective, multi-centered study aimed to improve high-quality radiation treatment (RT) planning workflows by training and testing a Convolutional Neural Network (CNN) to perform auto segmentations of organs at risk (OAR) for prostate cancer (PCa) patients, specifically the bladder and rectum. The objective of this project was to develop a clinically applicable and robust artificial intelligence (AI) system to assist radiation oncologists in OAR segmentation. The CNN was trained using manual contours in CT-datasets from diagnostic 68Ga-PSMA-PET/CTs by a student, then validated (n = 30, PET/CTs) and tested (n = 16, planning CTs). Further segmentations were generated by a commercial artificial intelligence (cAI) software. The ground truth were manual contours from expert radiation oncologists. The performance was evaluated using the Dice-Sørensen Coefficient (DSC), visual analysis and a Turing test. The CNN yielded excellent results in both cohorts and OARs with a DSCmedian > 0.87, the cAI resulted in a DSC > 0.78. In the visual assessment, 67% (bladder) and 75% (rectum) of the segmentations were rated as acceptable for treatment planning. With a misclassification rate of 45.5% (bladder) and 51.1% (rectum), the CNN passed the Turing test. The metrics, visual assessment and the Turing test confirmed the clinical applicability and therefore the support in clinical routine.
Enhancing the properties of high-density oil well cement with Qusaiba kaolinite
Authors: Ahmed Abdulmalek , Mahmoud Ahmed Abdulhamid , Elkatatny Salaheldin , Al Shehri Dhafer , Ayranci Korhan
Published: October 2024

High-density cement slurries used in oil well cementing often face challenges such as particle settling, poor rheological properties, permeability, and compressive strength degradation, which can compromise zonal isolation and well integrity. This study focuses on using kaolinite, a clay mineral, as an additive due to its potential to improve the performance of high-density cement by modifying key properties. Several concentrations of kaolinite were examined to evaluate their influence on several cement properties such as rheology, thickening time, permeability, porosity, and compressive strength. Additionally, it assesses the impact of kaolinite on cement sheath solids settling using both conventional methods and nuclear magnetic resonance (NMR). The results revealed that an optimal concentration of 1% kaolinite by weight of cement (BWOC) significantly reduced particle settling by 74.4%, enhanced compressive strength by 13%, and lowered permeability and porosity by 74% and 7%, respectively. Additionally, kaolinite improved rheological properties by an 8.4% reduction in plastic viscosity, a 19.4% increase in yield point, and a 30% increase in gel strength. Kaolinite also acted as a retarder, increasing thickening time. These improvements contribute to better cement sheath integrity and wellbore stability, highlighting kaolinite’s potential as an effective additive for high-density cement.
Parameter-coupled state space models based on quasi-Gaussian fuzzy approximation
Authors: Wang Yizhi , Ma Fengyuan , Tian Xiaomin , Chen Weina , Zhang Yang , Ge Shanshan
Published: October 2024

The accuracy of a fuzzy system’s approximation is closely tied to the performance of fuzzy control systems design, while this system’s interpretability depends on the description of a mechanical model using human language. This research introduces a quasi-Gaussian membership function characterized by a pair of parameters to achieve the sensitivity of a triangular membership function along with the interpretability of Gaussian membership functions. Consequently, a two-dimensional (2-D) quasi-Gaussian membership function is derived, and a method for establishing quasi-Gaussian fuzzy systems (QGFS) using a rectangular grid is proposed. After validating the approximation properties using the sine function for the one-dimensional (1-D) and 2-D QGFS, the systems are applied to approximate the depyrogenation tunnel, a significant piece of equipment in the pharmaceutical industry with various mechanical designs. Validation results indicate that the 1-D and 2-D QGFS can achieve an approximation error varying within a ± 5% range. Meanwhile, the 1-D and 2-D QGFSs are applied to mechanical models of the depyrogenation tunnel with satisfactory final approximation results. Lastly, the 2-D QGFS is capable of demonstrating an excellent description of models with coupled parameters.
Formulation of lipid nanoparticles containing ginsenoside Rg2 and protopanaxadiol for highly efficient delivery of mRNA
Authors: Park Sin A , Hwang Dajeong , Kim Jae Hoon , Lee Seung-Yeul , Lee Jaebeom , Kim Han Sang , Kim Kyung-A , Lim Bumhee , Lee Jae-Eon , Jeon Yong Hyun , Oh Tae Jeong , Lee Jaewook , An Sungwhan
Published: October 2024

We developed novel LNPs as an mRNA delivery system by replacing cholesterol with ginsenoside Rg2 and its derivative phytosterol protopanaxadiol (PPD). Both Rg2-LNP and PPD-LNP demonstrated highly efficient mRNA delivery and expression.
Identifying routes for transferring spin polarization from parahydrogen to protic solvents
Authors: Vaneeckhaute Ewoud , Tyburn Jean-Max , Kempf James G. , Martens Johan A. , Breynaert Eric
Published: October 2024

Repeatable hyperpolarization of high proton concentrations (>6 M) is accomplished at low-field by polarization transfer from p-H2 to hydroxyl protons via chemical exchange or cross-relaxation using hyperpolarized ammonia or pyridine respectively.
A cysteine-activated fluorescent H2S donor for visualizing H2S release and alleviating cellular inflammation
Authors: Wang Nianwei , Wang Xuan , Wang Jicheng , Ren Yikun , Hua Huiming , Li Dahong
Published: October 2024

We developed a Cys-activated fluorescent H2S donor, Bcy-NCS, which releases H2S and enables visualization through fluorescence changes, while also alleviating cellular inflammation.
Rhodium-catalyzed synthesis of Si-stereogenic alkoxysilanes and silyl enol ethers via hydrosilylation of carbonyl compounds
Authors: Ding Yang , Ke Jie , Zhang Wenbin , Li Bin , He Chuan
Published: October 2024

An efficient catalytic asymmetric hydrosilylation of aldehydes, ketones, and α,β-unsaturated ketones toward Si-stereogenic alkoxysilanes and silyl enol ethers is developed.
Electronic structure modulation via single atom interfacial engineering for selective atmospheric CO2 photoreduction
Authors: Shangguan Yangzi , Li Fuping , Feng Xuezhen , Wang Ranhao , Ge Qiuyue , Wu Xiaoyong , Chen Hong
Published: October 2024

Single atom Ir-modulated CuFeS2 QDs significantly enhance atmospheric CO2 photoreduction efficiency and selectivity, offering a promising strategy for practical applications.
I3− entrapped cationic Zn(ii) coordination polymer: selective detection and dose-dependent photocatalytic degradation of roxithromycin
Authors: Sharma Preeti , Ahmad Musheer , Haq Nazrul , Siddiqui Kafeel Ahmad
Published: October 2024

A zinc-based coordination polymer, {[Zn(BPMEDA)I]2+·2I3−}n, shows high stability in water and at various pH levels. It effectively detected and demonstrated strong photocatalytic degradation for antibiotics, highlighting its environmental potential.
DFT rationalization of the mechanism and selectivity in a gold-catalyzed oxidative cyclization of diynones with alcohols
Authors: Yan Guowei , Ma Ji , Qi Simeng , Kirillov Alexander M. , Yang Lizi , Fang Ran
Published: October 2024

The mechanism, regioselectivity, and chemoselectivity in a gold-catalyzed oxidative cyclization of diynones with alcohols to give furan-3-carboxylate derivatives were explored by density functional theory (DFT).
Exploring lithium ion interactions in graphite electrodes through non-equilibrium molecular dynamics and density functional theory
Authors: Shen Ding , Ren ZhaoQi , Wei Shuang , Ji YanZhen , Ma YongHui , Yang YouZhi , Dong Wei , Tang ShuWei
Published: October 2024

The relationship between the amount of lithium ion and the energy stability, diffusion coefficient and mechanical properties of graphite anodes for lithium ion batteries has been systematically revealed, using advanced MD and DFT methods.
Performance of functionalized graphene oxide with organic radical scavengers in proton exchange membranes
Authors: Hu Yu , Wang Jiaxing , Wang Shuai , Feng Yuan
Published: October 2024

A diazonium salt reaction is used to prepare benzoic acid-functionalized graphene oxide as a bi-functional filler for a Nafion membrane, and the corresponding composite membrane has improved chemical durability and proton conductivity.
Morphology optimization via pre-aggregation and miscibility matching in PM6:L8-BO ternary organic solar cells
Authors: Wei Chuyue , Zhang Junwei , Deng Jing , Yang Xiangyan , Luo Jiahui , Xu Zixiao , Zhang Lin , Yuan Shuaishuai , Zhou Weihua
Published: October 2024

Pre-aggregation and miscibility matching accounting for morphology optimization in ternary organic solar cells based on a PM6:L8-BO system.
Low-frequency (0–450 cm−1) dynamics of n-alkyl cyanide liquids studied by optical Kerr effect spectroscopy and density functional theory
Authors: Meng Dujuan , Sagala Sophia L. , Quitevis Edward L.
Published: October 2024

This work is the first one where the intermolecular and intramolecular dynamics of n-alkyl cyanide liquids have been studied systematically as a function of alkyl chain length.
Fundamentals of the recycling of spent lithium-ion batteries
Authors: Li Pengwei , Luo Shaohua , Lin Yicheng , Xiao Jiefeng , Xia Xiaoning , Liu Xin , Wang Li , He Xiangming
Published: October 2024

Fundamentals of battery recycling play a vital role in addressing the challenges posed by spent lithium-ion batteries by providing the theoretical foundation and technical tools necessary for the efficient recycling of LIBs.
Synthesis of Co3O4 catalysts with different morphologies and their excellent catalytic performance for soot combustion
Authors: Zhang Xinyu , Zhang Chunlei , Gao Siyu , Chen Xinyu , Chen Siyuan , Zhou Shengran , Yu Di , Wang Lanyi , Fan Xiaoqiang , Yu Xuehua , Zhao Zhen
Published: October 2024

A series of Co3O4 catalysts with different morphologies were prepared by a hydrothermal method. Among them, the sea urchin shaped Co3O4 catalyst exhibits the best catalytic performance for soot combustion.
Engineering in situ: N-doped porous carbon-confined FeF3 for efficient lithium storage
Authors: Hu Jinlong , Xu Weijun , Zhang Lingzhi
Published: October 2024

Achieving N-doped porous carbon-confined FeF3 with enhanced lithium storage performance via an innovative in situ engineering approach.
Synthesis and antifungal evaluation of new azole derivatives containing 1,2,3-triazole
Authors: Huang Zhengxiao , Chen Hongjie , Zhang Xiao , Wang Ruirui , Hu Chunyan , Mao Zewei
Published: October 2024

A series of novel azole derivatives containing 1,2,3-triazole have been synthesized with good antifungal effects on sensitive and drug-resistant C. albicans.
Amides of moronic acid and morolic acid with the tripeptides MAG and GAM targeting antimicrobial, antiviral and cytotoxic effects
Authors: Bildziukevich Uladzimir , Černá Lucie , Trylčová Jana , Kvasnicová Marie , Rárová Lucie , Šaman David , Lovecká Petra , Weber Jan , Wimmer Zdeněk
Published: October 2024

The most successful structures showing their antimicrobial, antiviral or cytotoxic effects. Selectivity of their effects has been observed.
Electrically switched asymmetric interfaces for liquid manipulation
Authors: Li Ke , Li Yuliang , Zhang Qiuya , Li Honghao , Zou Wentao , Li Lu , Li Yan , Zhang Xiaofang , Tian Dongliang , Jiang Lei
Published: October 2024

An electrically switched asymmetric interface can be used for direction-controlled liquid transport and fine droplet splitting on anisotropic groove-microstructured electrodes, which is promising in controllable separation and microfluidic devices.
A comprehensive review of challenges and advances in exosome-based drug delivery systems
Authors: Palakurthi Sushesh Srivatsa , Shah Brijesh , Kapre Sumedha , Charbe Nitin , Immanuel Susan , Pasham Sindhura , Thalla Maharshi , Jain Ankit , Palakurthi Srinath
Published: October 2024

Key challenges in exosomal based therapies.
The well-defined three-dimensional matrix of a micro-sized silicon/carbon composite promoting lithium-ion transportation
Authors: Wang Denghui , Ma Minghao , Xu Wenqiang , Ma Yingjie , Li Lidong , Li Xianglong
Published: October 2024

We constructed a well-defined three-dimensional micro-sized silicon/carbon matrix to achieve efficient omnidirectional ionic and electronic conductivity within micro-sized silicon.
An orange peel-derived zirconium-coordination polymer for highly efficient reductive upgradation of 5-hydroxymethylfurfural
Authors: Sun Siyu , Wan Ying , Li Zheng , Chao Lumen , Bai Yuanyuan , Liu Qunhua , Wang Can , Liu Wen , Ji Peijun
Published: October 2024

Both the use of renewable natural sources to prepare catalytic materials and the Meerwein–Ponndorf–Verley (MPV) reduction of carbonyl compounds are very attractive topics in catalysis.
Plant-mediated biosynthesized Au/CuO catalysts for efficient glycerol oxidation to 1,3-dihydroxyacetone: effect of biomass component on catalytic activity
Authors: Cui Li , Wang Fei , Zhang Xiaoli , Chen Yuewen , Liu Hai , Ke Yihu , Wang Yimin , Zhang Xiya
Published: October 2024

This study prepared a series of SoL-Au/CuO catalysts by isolating plant active ingredients. S3-Au/CuO enriched with polyphenols demonstrated the highest activity with a glycerol conversion of 86.6% and DHA selectivity of 82.0%.
Retraction: Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide
Authors: Zhang Wenjie , Taheri-Ledari Reza , Hajizadeh Zoleikha , Zolfaghari Ehsan , Ahghari Mohammad Reza , Maleki Ali , Hamblin Michael R. , Tian Ye
Published: October 2024

Retraction of ‘Enhanced activity of vancomycin by encapsulation in hybrid magnetic nanoparticles conjugated to a cell-penetrating peptide’ by Wenjie Zhang et al., Nanoscale, 2020, 12, 3855–3870, https://doi.org/10.1039/C9NR09687F.
Three-dimensional porous rhodium–copper alloy nanoflowers stereoassembled on Ti3C2Tx MXene as highly-efficient methanol oxidation electrocatalysts
Authors: He Haiyan , Lan Yue , Qin Jinlong , Jiang Quanguo , Yang Lu , Zhang Jian , Huang Huajie
Published: October 2024

An in situ soft-chemistry approach is adopted for fabricating 3D porous rhodium–copper alloy nanoflowers stereoassembled on ultrathin Ti3C2Tx lamellas, which are able to serve as highly-efficient electrocatalysts toward alkaline methanol oxidation.
Chalcogen bonds provide supramolecular association of beta-octamolybdate and chalconium cations
Authors: Kuznetsova Anna A. , Yanshole Vadim V. , Il'in Mikhail V. , Novikov Alexander S. , Bolotin Dmitrii S. , Sokolov Maxim N. , Abramov Pavel A.
Published: October 2024

Organic-inorganic supramolecular associates of chalconium cations and beta-octamolybdate anion unlock the potential of lacunary type polyoxometalates to serve as noncovalent ligands in the comparison with classical coordination chemistry of POM.
Polar and tropical regioisomeric decanuclear cuprofullerenes
Authors: Sun Jing-Xuan , Zou Ting-Ting , Zhang Yi-Chun , Liu Yu-Li , Dang Li , Zhan Shun-Ze , Cai Hong , Li Dan
Published: October 2024

Two polar and tropical coordinated decanuclear regioisomeric cuprofullerenes with CuI atoms coordinating on CC bonds of the two polar zones around pentagons and the tropical zone of the equator have been successfully assembled, respectively.
Multifunctional separator modified with catalytic multishelled structural CoS2 enables a stable lithium–sulfur battery
Authors: Bi Ruyi , Zhao Jilu , Yang Mei , Wang Jiangyan , Yu Ranbo , Wang Dan
Published: October 2024

A multifunctional separator modified with a multi-shelled CoS2 structure is developed to simultaneously inhibit the shuttle effect and effectively catalyze the redox reactions.
Iron-catalyzed thiolation of C(sp3)–H with sulfonyl chlorides via photoinduced ligand-to-metal charge transfer
Authors: Liu Sheng-Ping , Yang Lan , He Yan-Hong , Guan Zhi
Published: October 2024

A photoinduced FeCl3/HCl synergistic catalytic method enables C(sp3)–S bond formation via reductive cross-coupling of activated/inert C(sp3)–H and aryl/alkyl sulfonyl chlorides through ligand-to-metal charge transfer (LMCT).
Copper(ii)-catalyzed synthesis of sulfonyl-functionalized quinone-fused cyclopenta[b]indoles via four-component cascade annulation
Authors: Xu Hong , Liao Jie , Ren Fei , Zhou Chuan-Rong , Liu Xiao-Zhuo , Xiao Yao , Hang Dong-Wei , Li Fuyu , Wang Bei , Wang Ji-Yu
Published: October 2024

Through crucial selective radical tandem process and intramolecular nucleophilic addition, a facile copper-catalyzed four-component cascade has been realized to selectively construct novel sulfonyl-functionalized quinone-fused cyclopenta[b]indole.
Photocatalytic arylation/alkylation of olefins/alkynes via halogen-atom transfer mediated by NHC-BH3
Authors: Li Xinhan , Zhong Yao , Tan Fengsong , Fei Yusong , Zhao Xiaohan , Xu Jianbin , Fan Baomin
Published: October 2024

A versatile method for radical reductive cross-coupling of iodides and activated olefins under mild conditions, facilitated by NHC-BH3 through photocatalysis, was developed.
Synthesis of bambusurils with perfluoroalkylthiobenzyl groups as highly potent halide receptors
Authors: Chvojka Matúš , Valkenier Hennie , Šindelář Vladimír
Published: October 2024

Four new fluorinated bambusuril macrocycles were prepared to show exceptional high binding affinity towards halide anions in acetonitrile.
Mechanistic insight into the dehydrogenation reaction catalyzed by an MLC catalyst with dual ancillary ligand sites
Authors: Zhou Gui-Xiang , Hou Cheng
Published: October 2024

This study reveals a mechanism in which a ruthenium complex catalyst improves catalytic efficiency and lowers the energy barrier in the dehydrogenation of benzyl alcohol by dynamically switching ligand sites.
Efficient amide bond formation via tropylium ion organocatalysis
Authors: Hussein Mohanad A. , Al-Ameed Karrar , Almansori Ali K. , Owaid Naeemah Jabbar
Published: October 2024

An efficient method for amide bond formation is reported using tropylium ion organocatalysis. High yields are achieved under mild conditions with a broad substrate scope. DFT calculations were performed to assess substituent effects on reaction energies, tautomerism, and orbital splitting.
Colour tuneability of heteroleptic iridium complexes through second-sphere coordination
Authors: Balónová Barbora , Jones T. Harri , True Allison E. , Hetherington Sydney M. , Blight Barry A.
Published: October 2024

A series of H-bond-rich iridium(iii) complexes with different cyclometalating ligands bearing the general formula [Ir(C^N)2(N^N)] were synthesised. Their photophysical properties were elucidated along with properties imparted by their H-bond host–guest complement.
Recovery of uranium using epoxy-modified phosphorus pentasulfide as an efficient adsorbent for uranium extraction from aquatic environments
Authors: Badr Magd M. , Youssef W. M. , Elgammal Entesar M. , Hussien A. E. M. , Taha M. H.
Published: October 2024

Epoxy-modified phosphorus pentasulfide (EPMPS) formulation was developed for the supported recovery of uranium from aquatic environments.
A combined electro-optical deformability micro-cytometer
Authors: Zou Xueping , Spencer Daniel C. , Chen Junyu , Morgan Hywel
Published: October 2024

This paper describes a cytometer that measures the optical and electrical deformabilitiy of multiple single cells in a viscoelastic flow.
Prevalence and health risk evaluations of mycotoxins in drinking water sources in Nigeria
Authors: Koko Daniel T. , Alfred Moses O. , Bolujoko Nathaniel B. , Olorunnisola Damilare , Otitoju Oluwaferanmi B. , Alabi Peter , Ogunlaja Olumuyiwa O. , Okonofua Friday , Omonkhua Akhere A. , Msagati Titus A. M. , Omorogie Martins O. , Ogunlaja Aemere , Olukanni Olumide D. , Unuabonah Emmanuel I.
Published: October 2024

Mycotoxins in drinking water are neglected pollutants that have serious health implications when ingested.
Insulating materials based on silica aerogel composites: synthesis, properties and application
Authors: Goryunova K. I. , Gahramanli Y. N.
Published: October 2024

This paper focuses on the most recent advances in silica aerogel-based composite research, and indicates novel applications as insulation materials.
Precise air oxidation for continuous production of superparamagnetic Fe3O4 nanoparticles at room temperature through a microfilm reactor
Authors: Fang Jie , Li Hongyun , Zhu Wangyu , Xie Baogeng
Published: October 2024

Process intensification in a microfilm reactor enables reaction kinetics control and precise air fixation to produce pure and semi-monodisperse Fe3O4 nanoparticles.
Enhanced removal of emerging contaminants from tap water by developing graphene oxide and nanoplatelet hybrid aerogels
Authors: Gorgolis G. , Tunioli F. , Paterakis G. , Melucci M. , Koutroumanis N. , Sygellou L. , S. Bafqi M. S. , Saner Okan B. , Galiotis C.
Published: October 2024

The removal of emerging contaminants (ECs) from drinking water is a current challenge of global concern.
Computational study of novel 2H chromium ditelluride as an anode material for Li/K-ion batteries
Authors: Isa Khan Muhammad , Mehmood Iqra , Alarfaji Saleh S. , Junaid Muhammad , Iqbal Tahir
Published: October 2024

The goal of metal-ion battery research is to develop anode materials with high storage capacity.
Novel carboranyl-BODIPY conjugates: design, synthesis and anti-cancer activity
Authors: Mahanta Chandra Sekhara , Hansdah Sunitee , Khuntia Kabita , Jena Bibhuti Bhusan , Swain Biswa Ranjan , Acharya Subhadeep , Dash Barada Prasanna , Debata Priya Ranjan , Satapathy Rashmirekha
Published: October 2024

A series of BODIPY conjugates were synthesized. In vitro cytotoxicity against the HeLa cervical cancer cell line revealed that the carboranyl-BODIPY conjugates have the potential to be effective anticancer agents.
Photo-assisted (de)lithiation to enhance photoelectrochemical storage in quasi-solid-state Li-ion batteries
Authors: Mi Xin , Pan Jun , Duan Menglin , Huang Fuqiang , Qin Peng
Published: October 2024

Here, we constructed a dual-functional cathode using CsPbBr3 perovskites as the photo-responsive unit and lead phytate as the ion storage unit, offering a practical and sustainable method to achieve solar-driven electrochemical energy storage.
Towards efficient CO2RR electrocatalysts: a study of structure and properties of M–N–E active moieties embedded in a biphenylene framework (M = Mn, Fe, Co, Ni, Cu; E = C, B)
Authors: Zhao Zhengqin , Zibarev Andrey V. , Wang Hui , Hao Jinbo , Luo Lijia
Published: October 2024

Embedding M–N–B hybrid triad moieties in the BPN monolayer enhances the adsorption performance for intermediates through secondary bonding interactions.
Ohmic contact interface in the self-surface reconstructed Ni4Mo/MoO2 heterostructure for achieving effective alkaline electrocatalytic water splitting
Authors: Sivagurunathan Amarnath T. , Kavinkumar T. , Kim Do-Heyoung
Published: October 2024

We developed Ni4Mo/MoO2, a metal/n-type semiconductor junction forming ohmic contact in p–n junction for both OER and HER due to conversion of Ni4Mo into NiOOH and Ni(OH)2, respectively.
Installing active metal species in a covalent triazine framework for highly efficient and selective photocatalytic CO2 reduction
Authors: Jiang Yiqing , Xiong Liangliang , Guo Shien , Xu Chao , Wang Jiaxin , Wu Xiaomin , Xiao Yuting , Song Renjie
Published: October 2024

A phenanthroline-containing covalent triazine framework metalated with Ni sites (Ni-PT-CTF) has been rationally designed and synthesized, which shows excellent photocatalytic performance for CO2 conversion into CO under visible light irradiation.
Gas storage within nanoporous material encapsulated by ice
Authors: Goh Jia Ming , Yu Zhi , Zavabeti Ali , Shi Shuangmin , Guo Yalou , He Jianan , Yang Jianing , Dong Lei , Webley Paul A. , Ellis Amanda Vera , Li Gang Kevin
Published: October 2024

We present a novel approach for high-density gas storage at ambient pressure, leveraging the pore and surface properties of nanoporous materials and the natural behaviour of water.
Construction of a photonic radiative cooling layer based on a 3D conductive network foam for efficient electromagnetic interference shielding and environmental thermal comfort
Authors: Liu Mingtai , Huang Hongjian , Mei Jie , Yang Siqi , Tu Hao , Wang Jian
Published: October 2024

The environment on which people depend for their survival is becoming increasingly complex and deteriorating due to increasing electromagnetic pollution and extreme hot weather.
Lure the “enemy” deep: an innovative biomimetic strategy for enhancing the microwave absorption performance of carbon nanofibers
Authors: Deng Yu , Yang Minghang , Wang Yining , Zhang Mingguang , Zhou Shuaining , Lu Xiangyang , Jian Xigao , Chen Yousi
Published: October 2024

The high conductivity inherent to the dense graphite structures of carbon nanofibers (CNFs) results in microwave reflection, making it a noteworthy topic to design structures that endow CNFs with microwave absorption capabilities.
Single-ion conductor gel polymer electrolytes enabling an anionic polymer-induced solid electrolyte interphase for dendrite-free lithium-metal batteries
Authors: Duan Ping-Hui , Zhu Guo-Rui , Yu Jia-Ling , Guan Zhe , Gao You , Wu Gang , Wang Xiu-Li , Wang Yu-Zhong
Published: October 2024

A novel 3D crosslinked single-ion conductor gel polymer electrolyte to construct an anionic polymer-induced SEI can achieve low interfacial impedance, a stable electrolyte/electrode interface, and effective suppression of lithium dendrite growth.
Modulating the electronic interactions via heterostructure engineering for energy-saving hydrogen production at high current densities
Authors: Tan Dongxing , Yin Xianfang , Wang Jing , Zhang Zixuan , Zhu Xiao , Kang Hengrui , Feng Yuanyuan
Published: October 2024

The Ni0.2Mo0.8N/F,N–C catalyst facilitates water dissociation and accelerates the kinetics process, achieving high activity in hydrogen production when assisted by the MOR.
Modulation of biomineralization morphology by phosphorylated collagen peptides: insights into osteogenesis imperfecta pathophysiology
Authors: Nian Linge , Li Wenhua , Tian Xinyu , Wei Guochen , Wu Qingfeng , Xiao Jianxi
Published: October 2024

Phosphorylated collagen peptides modulate the biomineralization of calcium carbonate, resulting in distinct nanostructure morphologies. This study offers new insights into the role of phosphorylation in the pathogenesis of osteogenesis imperfecta.
Multimodal layer-by-layer nanoparticles: a breakthrough in gene and drug delivery for osteosarcoma
Authors: Crisafulli Eugenia , Scalzone Annachiara , Tonda-Turo Chiara , Girón-Hernández Joel , Gentile Piergiorgio
Published: October 2024

This study explored biodegradable nanoparticles for treating osteosarcoma. Co-delivery of miRNA-34a, doxorubicin, and resveratrol by LbL nanocoating enhanced apoptosis and cell disruption with promise to improve efficacy and reduce drug resistance.
A water playground for peptide re-assembly from fibrils to plates
Authors: Adorinni Simone , Kurbasic Marina , Garcia Ana M. , Kralj Slavko , Bellotto Ottavia , Scarel Erica , Pengo Paolo , De Zorzi Rita , Melchionna Michele , Vargiu Attilivio V. , Marchesan Silvia
Published: October 2024

Water plays a key role in the irreversible transition from peptide fibrils to plates.
Lactobionic acid modified cobalt coordination polymer-coated peroxymonosulfate nanoparticles generate sulfate/hydroxy dual-radicals for targeted cancer therapy
Authors: Li Jiahui , Li Jiaxuan , Chen Zelong , Wan Yichen , Wang Yi , Pei Zhichao , Pei Yuxin
Published: October 2024

LCP NPs were prepared by forming a coordination polymer on peroxymonosulfate through the coordination between imidazole-2-carboxaldehyde and Co2+, then modified with lactobionic acid to improve the efficacy of sulfate/hydroxy dual-radical therapy.
Highly sensitive OFET based room temperature operated gas sensors using a thieno[3,2-b]thiophene extended phthalocyanine semiconductor
Authors: Isci Recep , Yavuz Ozgur , Faraji Sheida , Gunturkun Dilara , Eroglu Mehmet , Majewski Leszek A. , Yilmaz Ismail , Ozturk Turan
Published: October 2024

A novel thienothiophene (TT) and phthalocyanine (Pc) based conjugated material was designed, synthesized, fabricated for an organic field effect transistor (OFET) and utilized as an OFET based gas sensor for hazardous gases such as NO2 and SO2.
Enhancing the NO2 detection ability of surface acoustic wave sensors with ZnO-decorated N-doped porous carbon nanosheets
Authors: Li Xue , Feng Yuan , Lv Haifeng , Shi Junjie , Guo Yuanjun , Li Sean , Zu Xiaotao
Published: October 2024

The ZnO provides abundant adsorption sites of NO2 to the N-PCNs, optimizing the sensing mechanism of N-PCNs for NO2, and significantly reinforcing the NO2 detection ability of sensing layers for SAW sensors.
High stability of robust anti-thermal-quenching lead-free double perovskite crystals for optoelectronic devices and high-performance fibers
Authors: Zhang Xiaoman , Zheng Yehua , Nie Kun , Zhang Xiaodong , Duan Xiuqiang , Hu Ziyao , Yang Ming , Mei Lefu , Wang Luoxin , Wang Hua , Li Mingquan , Ma Xiaoxue
Published: October 2024

Sb3+-doped Cs2NaHoCl6 perovskite crystals were synthesized through an efficient and energy-saving method. The flexible luminescent fibers prepared from Sb3+-doped Cs2NaHoCl6 exhibit excellent luminescent stability in high-temperature environments.
Hybrid nano-microstructured and bioinspired conductive hydrogels with tunable multifunctionality
Authors: Wang Manting , Zhang Jiaqi , Guo Yaoyi , Zhou Xiaoyong , Wang Jie-Xin , Le Yuan
Published: October 2024

A conductive hydrogel with enhanced mechanical properties and excellent multifunctionality is fabricated by facile direct in situ polymerization. This hydrogel can serve as a wearable strain sensor precisely detecting relative resistance changes.
Imide-free electron-deficient electrolytes with adjustable cathode-modifying capabilities achieved by side chain engineering for efficient organic solar cells
Authors: Chen Guiting , Wang Long , Wu Hongli , Li Long , He Baitian , Dai Chuanbo , He Zhicai
Published: October 2024

The performance of organic solar cells can be regulated by altering the alkyl chains on quaternary ammonium groups of cathode interface materials, and a power conversion efficiency of 18.54% is realized in D18:L8-BO-based devices.
Cytotoxic and molecular effects of soil extracts from the Agbogbloshie electronic-waste site on fish and human cell lines
Authors: Mittal Krittika , Xu Ke , Zheng Jingyun , Bayen Stephane , Fobil Julius , Basu Niladri
Published: October 2024

Effect-based methods (EBM) are of growing interest in environmental monitoring programs.
Microbial degradation of bioplastic (PHBV) is limited by nutrient availability at high microplastic loadings
Authors: Reay Michaela K. , Graf Martine , Greenfield Lucy M. , Bargiela Rafael , Onyije Charles , Lloyd Charlotte E. M. , Bull Ian D. , Evershed Richard P. , Golyshin Peter N. , Chadwick David R. , Jones Davey L.
Published: October 2024

Degradation of PHBV in soil, quantified with pyrolysis GC-MS, was nutrient limited at increasing microplastic concentrations. Hydrophobicity increased while plant and soil microbial biomass decreased at higher soil microplastic concentrations.
Multiple ASC-dependent inflammasomes drive differential pro-inflammatory cytokine production in a mouse model of tendinopathy
Authors: Peñín-Franch Alejandro , Hurtado-Navarro Laura , García-Vidal José Antonio , Escolar-Reina Pilar , Medina-Mirapeix Francesc , Pelegrin Pablo
Published: October 2024

Inflammasomes are multiprotein complexes that regulate the bioactive production of IL-1β and IL-18, being implicated in the inflammatory response of different diseases. The inflammasome formed by the cytosolic sensor NLRP3 is highly promiscuous, as it could be activated by different pathogen- and sterile-signals. However, few models have studied the implication of NLRP3 in tissue damage-induced inflammation, particularly the implication of NLRP3 in tendinopathies. Here, we aimed to investigate the implication of NLRP3 in a mouse model of tendinopathy by collagenase degradation of the extracellular matrix in the Achilles’ mice tendon. We found that NLRP3 was involved in the production of IL-1β, but another ASC-dependent inflammasome was required to produce IL-18 during sterile tissue damage. Our study suggests that in the immune response to extracellular matrix degradation different inflammasomes, probably expressed in different cell compartments, were able to differentially control IL-1β and IL-18 production in vivo. These results suggest the potential use of therapies targeting ASC as beneficial in the treatment of tendinopathies.