bluuebunny/crossref_metadata_2025 huggingface dataset:
Modern strategy for management of pediatric patients with gastroesophageal reflux disease in compliance with the international and national guidelines
Authors: Kryuchko T. O. , Nesina I. M. , Poda O. A. , Bubyr L. M.
Published: December 2023

Recent epidemiological studies demonstrated that gastroesophageal reflux disease (GERD) takes a leading place among acid‑dependent gastroenterological diseases. The problems of GERD development prevention and its treatment are topical since GERD significantly reduces the quality of life, especially when extraesophageal symptoms appear. Timely and correct GERD diagnosis, treatment and monitoring in pediatric patients prevents the development of complicated course of the disease in adults. Last decade, priority attention has been given to improving the quality of medical care in most countries worldwide. To achieve this purpose, effective medical care should be provided and the results of treatment of patients should be improved.
The review presents analysis of current strategies for GERD diagnosis and treatment in pediatric patients based on the international and national guidelines. To ensure the proper quality of medical care, it is necessary to standardize approaches to diagnosis and treatment of diseases in childhood. The preparation of the Medical Standards of Care «Gastroesophageal Reflux Disease in Children» by a multidisciplinary group of experts and the adaptation of the clinical guideline are purposed to the improvement of existing diagnostic and treatment approaches to GERD pediatric patients in Ukraine, to ensuring high‑quality and effective medical care and establishing the uniform requirements for prevention, diagnosis and treatment of this group of patients. The results of modern investigations, based on international consensuses on the GERD diagnosis and treatment in childhood, have been highlighted. The latest information on the expediency of administration of instrumental examinations and treatment tactics has been presented.
Cortisol level in mixed saliva as a marker of periodontal lesions in metabolic associated diseases
Authors: Emelyanova N. Y.
Published: December 2023

Dysregulation of cortisol levels at account of the increase in inflammatory mediators increases the risk of developing metabolic associated diseases, suppresses secretion of secretory immunoglobulins and neutrophil function, which results in a decrease in protection against periodontal pathogens in the oral cavity.
Objective — to evaluate the possible association of salivary cortisol levels with the main inflammatory markers of metabolic associated diseases and periodontal disease.
Materials and methods. The study included 67 patients, 44 of whom had cardiometabolic diseases. The comparison group consisted of patients, matched by sex and age who did not have clinical manifestations of metabolic associated diseases. To confirm the underlying disease, patients underwent assessment of carbohydrate and lipid metabolism, questionnaire survey on the main dental complaints and a dental examination, and evaluation of salivation rate, saliva viscosity and determination of cortisol level of mixed saliva with enzyme linked immunosorbent assay. Statistical analysis was performed using SPSS software with the calculation of the mean value M, standard error, Student’s test. Percentages were compared using the z‑criterion. The Pearson correlation test was used to identify the relationship between indicators.
Results. Significantly higher levels of mixed salivary cortisol were recorded in patients of the main group (3.34±0.20 ng/ml) (p <0.05). Direct correlation has been established between cortisol levels and presence of diabetes mellitus (r=0.342; p=0.016), levels of blood glucose (r=0.379; p=0.002), low‑density lipoprotein cholesterol (r=0.348; p=0.017); indirect correlation was established with non‑alcoholic fatty liver disease (NAFLD) through triglycerides levels (r=0.345; p=0.007). In addition, reverse correlations were observed between cortisol and alkaline phosphatase (r=–0.328; p=0.0014), salivation rate and the presence of metabolic associated diseases (the most significant with NAFLD (r=–0.499; p=0.000)).
Conclusions. Under conditions of prolonged chronic stress, patients with metabolic associated diseases have a significantly increased rate of gingival lesions. The study of cortisol in mixed saliva is a convenient non‑invasive method that allows the assessment of the presence of chronic stress in patients, as well as its impact on the development, duration, chronicity and response to treatment of metabolic associated diseases.
The significance of catestatin and relaxin-2 in the diagnosis of myocardial remodeling in patients with essential hypertension and type 2 diabetes mellitus
Authors: Pankova O. A. , Korzh O. M.
Published: December 2023

Objective — to evaluate the peculiarities of electrocardiographic (ECG) and echocardiographic (EchoCG) parameters in patients with essential hypertension (EH) in combination with type 2 diabetes mellitus (T2DM) and their relationships with plasma catestatin (CTS) and relaxin­‑2 (RLN­­2) levels.
Materials and methods. Examinations involved 106 patients with EH, from whom 55 subjects had concomitant T2DM, and 30 practically healthy volunteers. The mean age of the participants was (64.06±8.44) years, and women prevailed in the patients’ group (55.9%). All study participants underwent anthropometric data measurement, laboratory and instrumental investigations. The levels of biomarkers CTS and RLN­­2 were determined with the enzyme‑linked immunosorbent assay. Instrumental investigations included electrocardiography and transthoracic echocardiography.
Results. CTS levels were reduced in patients with concentric (5.04±1.14 ng/mL) and eccentric left ventricular hypertrophy (LVH) (5.08±0.89 ng/mL) compared with the normal geometry (6.63±0.73 ng/mL, p <0.001). The significant correlation has been established between CTS levels and ECG parameters of LVH (Cornell voltage criterion (r=–0.222; p=0.009) and Sokolow‑Lyon index (r=–0.226; p=0.008)), and EchoCG parameters, including LV end‑diastolic dimension (EDD (r=–0.388; p <0.001), LV end‑systolic dimension (ESD (r=–0.453; p <0.001), LV end‑diastolic volume index (EDVi (r=–0.329; p <0.001), LV end‑systolic volume index ESVi (r=–0.415; p <0.001), LV ejection fraction (EF (r=0.469; p <0.001), septal sickness (SS) (r=–0.593; p <0.001), posterior wall thickness (PWS) (r=–0.647; p <0.001), relative wall thickness (RWS) (r=–0.568; p <0.001), and LV myocardial mass index (LVMi) (r=–0.576; p <0.001). Patients with RLN­­2 ≥ 4.69 pg/mL had higher EchoCG parameters, including LV EDD, LV ESD, LV EDVi, LV ESVi, SV, SS, PWS, RWS, LVMi (p <0.05). In addition, a significant positive relationship between CTS and RLN­­2 levels has been revealed (r=0.191; p=0.026), which was also confirmed in the subgroup of patients with RLN­­2 levels above 4.69 pg/mL (r=0.585; p <0.001).
Conclusions. The decrease in CTS levels at LVH and established correlations with the ECG signs of LVH and EchoCG parameters allow us to consider CTS as a predictor of the development of LVH, especially in patients with EH combined with T2DM.
The relationship between polymorphic variants of the endothelial NO-synthase gene and the course of diabetic nephropathy in patients with type 2 diabetes mellitus
Authors: Nesen A. O. , Semenovykh P. S. , Savicheva K. O. , Galchinska V. Y.
Published: December 2023

Objective — to identify a possible association between the endothelial nitric oxide synthase (eNOS) gene G894T (rs1799983) polymorphism and the markers of renal function and glucose metabolism in patients with type 2 diabetes mellitus (DM2) with diabetic nephropathy (DN).
Materials and methods. Examinations 126 patients with diabetic nephropathy (DN). The control group included 20 healthy individuals. Patients with DM2 were divided into two groups depending on the eNOS rs1799983 gene polymorphism: group I — patients with DN and G/G genotype eNOS G894T gene (n=80); group II — patients with DN and G/T and T/T genotypes eNOS G894T gene (n=46). Genotyping of the of the eNOS rs1799983 gene polymorphism was performed by the Taq‑Man® Fast Universal PCR Master Mix (Applied Biosystems, USA) and TaqMan® SNP Assay (Applied Biosystems, USA).
Results. It has been established that in patients with DN, the distribution of genotypes of the G894T polymorphism of the eNOS gene corresponded to the Hardy‑Weinberg equilibrium in all groups and does not differ significantly from European populations. In diabetic patients with DN the 3 times higher total frequency of G/T and T/T genotypes eNOS G894T gene was established when compared to the control group. These findings prove the undoubted influence of the T allele on the development of DN in this group of patients. DN patients with genotypes G/T and T/T had significantly higher blood glucose and HOMA index (p <0.05) than G homozygotes (genotype G/G). Patients with DN and G/G genotype eNOS G894T gene had better glomerular filtration rate and lower albuminuria compared to patients with G/T and T/T genotypes (p <0.05).
Conclusions. The establishing of association of eNOS gene polymorphism with the disease and further assessment of individual genetic risk is important for the development of a differentiated approach to the prevention and treatment of DN in patients with DM2 depending on the hereditary predisposition of an individual patient. Therefore, currently one of the most progressive approaches is to develop a strategy for early diagnosis, prognosis and preventive therapy of the disease using genetic markers.
Y Kuşağının Spor Ayakkabısı Markalarına Sadakatinde Marka Aşkının Etkisinin Araştırılması
Authors: ÖNER Merve , GÜRBÜZ Esen
Published: December 2023

Pazarlarda her geçen gün artan marka sayısı ile yoğunlaşan rekabet ortamının gelişimine paralel olarak, pazarlama strateji ve taktiklerinin de genişletilmesi gerekliliği ortaya çıkmıştır. Marka aşkı ve marka aşkının sağlanmasında uygulanabilecek strateji ve taktikler bunlardan birisidir. Marka sadakatini etkileyebilen marka tatmini, marka değeri, algılanan değer, algılanan risk, algılanan kalite vb. sağlanmasının gerekliliği hala güncelliğini ve önemini korurken bunlarla birlikte, yoğun rekabet ortamında dikkatler, marka aşkının sağlanmasına yönelmiştir. Marka aşkının marka sadakati yaratmada ne düzeyde etkili olduğu araştırma problemidir ve Y kuşağının, spor ayakkabısı ürünlerine marka sadakati göstermelerinde marka aşklarının etki düzeyinin belirlenmesi ve spor ayakkabısı ürünlerine marka aşkı ve sadakati göstermelerinde, demografik özelliklerinin farklılık gösterme durumunun araştırılması, amaçlanmaktadır. Y kuşağının %73,4’ünün öncelikli olarak tercih ettiği bir spor ayakkabı markası bulunmakta olup, bu markalara duydukları “yakınlık ve bağlılık” ile “tutku” boyutlarında açıklanan marka aşkları, marka sadakatlerini %76 düzeyinde açıklamaktadır. Marka aşkındaki 1 birimlik değişme marka sadakatini 0.46 düzeyinde artırmaktadır. Spor ayakkabısı markalarına gösterilen marka aşkı ve marka sadakatleri cinsiyet, gelir, eğitim düzeyi ve mesleklerine göre farklılık göstermemektedir.
Potentiality of natural live food organisms in shrimp culture: A review
Authors: Sharma Khushbu , Gulati Rachna , Singh Sushma , Kumari Ankur , Sharma Pankaj
Published: December 2023

The aquaculture industry is growing quickly due to increased fish consumption and a decline in wild fish catch. About half of the world's seafood demand for human consumption is now met by farmed seafood. The aquafeed market is expanding along with the aquaculture sector. Some of the elements in shrimp feed are derived from terrestrial plants and low-value forage fishes (fish meal). It is impossible to produce more fish meals since doing so would harm the ocean's environment and sustainability. The reduction in shrimp feed cost can also be done by introducing low-cost, environment-friendly ingredients in shrimp feed formulation. Therefore, new and ecologically friendly shrimp (Litopenaeus vannamei) feed component sources must be created. Live food organisms are a preferable option for this since they provide a variety of essential amino acids and beneficial triglycerides like fat, vitamins, and colors in their cell metabolites. Microalgae biomasses also represent feasible ingredients for shrimp feed sources. Their distinctive variety of bioactive chemicals can enhance color and pellet quality, act as a bulk element in shrimp feed, and boost the viability of farmed species. Live food organisms have a great economic potential since they have the highest  biomass productivity of all photosynthetic organisms. In addition to giving farmers and exporters a better choice for feeding their fish, the availability of on-grown live food would also open up the prospect of improving the performance and quality of the fish and shrimp through bioencapsulation. This review study examines the possibility of generating natural food biomass as a component in shrimp feed.
Comparative analysis of morphological and biochemical properties of some Mulberry (Morus spp.) genotypes
Authors: Gharibi Hosseinali , Moghadam Alireza Ladan , Alizadeh Mahdi , Baghdadi Goni
Published: December 2023

Mulberry is a multipurpose tree in horticulture. Besides nutritional importance, it is used for raising silkworms, fodder and landscape. These is quite a wide genetic diversity among different mulberry genotypes. The present study was undertaken to evaluate certain morphological and biochemical properties of 20 genotypes of Morus alba, M. rubra, and M. nigra species distributed in Golestan Province, northern Iran. The highest leaf length (15.51 cm), petiole length (5.37 cm), vitamin C (4.34 mg/100 g) and phenol (31.89 mg/g) were recorded in M12 genotype. The highest fruit length (5.52 cm), pedicle length (17 mm), soluble solids (18.26%) and sucrose (31.64 mg/g) were recorded in M10 genotype. The amount of glucose (288.82 mg/g) and fructose (121.97 mg/g) were also dominant in M17 genotype. The utmost fruit fresh and dry weights (0.3-67.80 g), fruit diameter (1.99 cm), leaf width (11.94 cm) and flavonoids (24.67 mg/g) were also observed in the M20 genotype. The M1 and M2 genotypes had higher anthocyanin (1.13 µmol/g) and total antioxidant activity (66.71%) compared to other genotypes. Furthermore, fruit fresh and dry weights were positively correlated with fruit length and diameter, pedicle length, and leaf and petiole length. The highest positive correlation was observed among anthocyanin, vitamin C and phenols. The morphological and biochemical traits explained 99 % of the total variance of four and three main components. The results of cluster analysis grouped these genotypes into 3 main groups. Therefore, the highest heritability and genetic advance were found for fruit weight, petiole length, leaf width, antioxidant activity, fructose and flavonoids. The valuable pomological traits recorded for some genotypes may be useful for future breeding programs.
Community structure and functional diversity of soil nematodes from Udupi district, Karnataka, India
Authors: M V Keshava Murthy , A. Shwetha
Published: December 2023

Nematodes constitute the most significant, most numerous, and diversified set of multicellular organisms on the earth. They live in various environments and exhibit a wide range of behavioural patterns. In the soil food web, they can be found at various trophic levels as herbivores (plant parasitic nematodes), bacterivores, fungivores, omnivores, and predators. As there were fewer studies on nematode ecology in the Udupi region, the present study aims to study the community structure and functional diversity of soil nematodes. Soil samples were collected following opportunistic random sampling employing a soil auger and were stored at 40C until transported to the laboratory. Nematodes were isolated from soil, killed, fixed, dehydrated, and displayed on a glass slide after isolation. The standard keys were used to identify the individual to genera level. 62 genera of soil nematodes belonging to 26 families and 7 orders were identified. Predator were the most prevalent communities. Various statistical indices for assessing nematode population ecology and nematodes specific indices were also calculated and it indicated a significant abundance of large plant parasitic nematodes. The region exhibits low levels of labile organic carbon and nutrient enrichment (Enrichment Index (EI):14.06 to 21.22). Despite this, the soil food web in the region is well-structured, indicated by Structure Index (SI) (85.51 to 89.74). Prevalence of fungal decomposition dominance and the soil appears to be minimally disturbed, as indicated by high channel index values and low Basal Index (BI) values, respectively
Establishing surface sterilization protocol for clonal apple rootstock MM106
Authors: Lal Manmohan , Jamwal Mahital , Bakshi Parshant , Sharma Nirmal , Sood Yachna , Jasrotia Amit , Sharma Arti , Sharma Sushma , Sharma Reetika
Published: December 2023

Surface sterilization is crucial in preparing viable and uncontaminated explants for tissue culture. Utilizing the right sterilizing agent in this procedure can efficiently eliminate the majority of surface contaminants. The present study aimed to establish the best sterilization procedure for clonal apple rootstock MM106 using shoot tips and nodal segments. Two important sterilizing agents, mercuric chloride (ranging from 0.05% to 0.3%) for various durations (2 to 6 minutes) and sodium hypochlorite (ranging from 3.0% to 12%) for different durations (10 to 30 minutes), were employed. The results indicated that the maximum aseptic conditions (80.00% and 80.67%) and survival rates of the cultures (60.66% and 67.33%) for shoot tips and nodal segments, respectively, were achieved through surface sterilization with 0.1% mercuric chloride for 4 minutes, specifically during April, in comparison to March and May of 2021 due to low phenol content and high meristematic activity. The results yielded valuable insights for efficiently propagating clonal apple rootstocks on a local scale, and they have the potential to offer guidance for establishing commercial facilities dedicated to producing these specific clonal apple rootstocks and varieties.
Phylogenetic monitoring of Escherichia coli in medical wastewater/Baghdad City
Authors: Mahdi Zinah Mohammed , Baqer Noor Nihad , Mahmood Shahad Hisham , Jaffar Mohammed Adil
Published: December 2023

Clean drinking water access is a main factor that supports general health worldwide, where important investment is made to maintain water quality. The gene sequence of 16S rRNA was applied to study bacterial phylogenesis and classification. This studyaimed to isolate new bacterial strains from wastewater environments. Thisstudy collected water samples from differentwastewater sites for Baghdad Medical City’s Hospital. The results of Vitek 2Compact were with a probability of99% forEscherichia coli isolates .The bacterial isolates were identified using Polymerase chain reaction (PCR) based on the universaldiagnostic gene 16SrRNA, and the PCR product was obtained with a molecular weight of 1250bp. The PCR productsequencingshowed 166 isolates of E. coli different from the isolates registered in the NCBI database of E. coli after alignment between them.The present study reported 16 Iraqi isolates in NCBI with an accession number: OM032663.1; OM 032664.1; OM294659.2;ON724178.1; ON724264.1; ON724331.1; ON725076.1; ON725091.1; ON725139.1; ON725141.1; ON739200.1; ON739201.1;ON739207.1; ON739208.1; ON739209.1; ON739211.1. The identity was then observed(96-100%) with strains in Gene Bank.There were many different sequence position substitutions (transition, deletion, transversionfor the registered local isolates whenconducting multiple alignments and comparing themwith the isolates in the Gene Bank. According to the phylogenetic treebuilding by joining-the neighbor method, the local Iraqi isolates clustered into sub-descents. Moreover, local isolates of E.coliappeared more convergent to Saudi Arabia isolates (KY780347.1). This may be due to the geographical proximity of the two countries to the same Arab Gulf region .The present study identified 16 isolates of E. coli from the Iraqi aquatic environment (medical wastewater). The novelty of this study was represented to monitoring the evolution of E. coli in medical wastewater.
A comparative study of soil fertility and biota population under organic, semi-organic, and conventional farming system of rice fields in Giriwoyo District, Wonogiri Regency, Indonesia
Authors: Mujiyo  , Oryza Sefina Fauzia , Suntoro  , Herdiansyah Ganjar
Published: December 2023

Continuous use of chemical fertilizers and farming practices in rice fields would reduce nutrient availability and biota population in the soil. Because soil biological linkages are sensitive to changes in soil function, changes in fauna and microbial populations can affect soil fertility. This study aimed to identify the condition of soil fertility and soil biota under various farming systems, namely organic, semi-organic, and conventional, and find the indicators that determine soil fertility index (SFI) in the research area. This research is a survey with the sampling method was purposive on the Land Mapping Unit (LMU) overlaid with thematic maps (land use, soil type, slope, and rainfall). The method analysis of SFI using Principal Component Analysis (PCA) and scoring methods were used for the effect of farming systems using One-way, continued by DMRT, and determinant factor using Pearson’s. Correlation. The results illustrated that soil fertility was a moderate category. The highest SFI was in organic rice fields (0.69), then in semi-organic (0.62), and the lowest fertility was in conventional (0.59). Organic farming also showed the best soil biota conditions (0.27 individuals/liter of earthworms and 0.755 µ/g of microbial C biomass) compared to semi-organic (0.15 individuals/liter, 0.508 µ/g microbial C biomass) and conventional farming (0.11 individuals/liter, microbial biomass C 0.325 µ/g). Soil fertility and soil biota are positively correlated, meaning that the higher the soil fertility, the higher the density of soil biota. The soil indicators most determining fertility are total N, P-available, K-available, CEC, and organic C.
High Performing Work System and Emotional Intelligence among Working Women
Authors: Nematullah Islmzai
Published: December 2023

The study aims to understand how the implementation of HPWS influences the development of emotional intelligence in female employees and how this relationship, through a literature review, empirical analysis, and case studies, this paper provides insights into the significance of integrating HPWS and EI in the workplace, shedding light on strategies to empower working women. As gender disparities persist in contemporary workplaces, the need to comprehend the mechanisms by which HPWS can potentially enhance EI, thereby bolstering the performing and well-being of female employees, has become increasingly imperative. By drawing from a multitude of research approaches, this paper synthesizes and advances our understanding of these multifaceted interconnections and elucidates the symbiotic relationship between HPWS and EI in the context of female employees within the workforce. It underscores the imperative for organizations to adopt strategies that encourage the development of emotional intelligence among women, not only as a means of promoting gender equality but also as a viable pathway to enhance job performing and overall well-being. By integrating a multifaceted research approach, this study contributes to the academic discourse and provides practical guidance for organizations aiming to foster an inclusive and empowered workplace for women.
Regional Public Services Agency Income, Retribution Revenue, and Non-Capitation Funds BPJS Health at Kemayoran District Public Health Center, Central Jakarta Administration City
Authors: Setiawati Sri , Thantawi Ahmad Muhammad , Kurniasari Isnaini Hijriyah , Budiasih Yanti , Lubis Amanda Lestari Putri , Iskandar Fahmi
Published: December 2023

Regional Work Unit of Regional Public Services Agency has been granted the authority to manage the income generated by the services provided to the public in order to improve service quality. Retaliation is deducted from the costs of medical care that the uninsured patient pays. Whereas, Non-capitation funds paid by the Health Social Security Administrator (BPJS Kesehatan). This study aims to know the effect of Health Service Retribution Revenue and Non-Capitation funds of the revenue of BPJS Health toward income, how great the impact is. This study is done in Public Health Center in Kemayoran District. Quantitative method is used as the method of the study. And secondary data is used as the data of the study. Classical Assumption Test and Hypotheses Testing, such as multiple regression equations, are used as the statistic method. T test and f test with significant level 5%. The data is processed using SPSS 25 program. The results are based on Retribution Revenue data, Non-Capitation funds, and Regional Public Services Agency of Public Health Center Revenue in Kemayoran District in 2014 to 2018. All of the data showed that Retribution Revenue data, Non-Capitation funds and Regional Public Services Agency of Public Health Center Revenue results, significantly and positively toward BPJS services.
Amelioration of Behavioral and Cognitive Impairment of Ethanolic Leaf Extract of Ziziphus Talanai Against MSG in Mice
Authors: Nolasco Glen , Escoto Graciela Ann , David Lourdes Fatima , Te Aaron Carl , Yamauchi Frienchie Ann
Published: December 2023

Ziziphus talanai is an endemic plant species in the Philippines. Recently, this plant's phytochemical analysis revealed pivotal compounds with different pharmaceutical properties, including the neuroprotective activity in the mice cerebellum. Nonetheless, the scarcity of information on the neuroprotective potential of this plant has been a focal point. Thus, this study aimed to evaluate the neuroprotective potential of Z. talanai extract against MSG-induced aberrations in mice. A total of 24 mice were distributed and administered 9000mg/kg of MSG (T-), MSG and 1000mg/kg of L-taurine (T+), 100% of extract (T1), MSG, and 25% extract (T2), MSG and 50% of the extract, MSG and 75% extract, and MSG and 100% of the extract. The results of the test crawling along the rope showed that mice treated with MSG exhibited anxiety-like behavior, while mice treated with L-taurine managed to surpass the atrocious effect of MSG. In mice treated with the extracts, it is revealed that there is anxiolytic effect that has direct relation between the concentration and results. The results of the Y-maze test obtained significant differences between the MSG-treated group versus extract alone, L-taurine, 50%, 75%, and 100% extract. Interestingly, a 75% concentration of the plant extract was the most promising of the group results. These justify the ameliorative potential of Z. talanai extract on the behavior deficits and cognitive impairment of mice treated with MSG.
THE FUTURE OF LAST MILE LOGISTICS
Authors:   Odessa National Maritime University, Zhuchenko A. , Yatsina Ye. ,   Odessa National Maritime University, Moskvichenko I. ,   Odessa National Maritime University
Published: December 2023

Last mile logistics refers to the operational capabilities available to companies. The challenges facing last mile logistics are: above all, with a quick response to consumer expectations. This is why flexibility seems so important, both in terms of delivery efficiency and speed of adaptation to new conditions. They determine the choice of supplier. We must not forget that the customer also expects low delivery costs. The future of last mile delivery will be built on key technologies such as: - autonomous delivery systems using a combination of self-driving cars, sidewalk robots and drones to minimize last-mile inefficiencies; - serial production, bringing execution closer to the end customer, ensuring faster delivery at a lower price; - robotic stores on wheels that transport goods directly to the consumer's doorstep, increasing delivery volume with added convenience; - “cabinets” for delivery and storage systems that increase the efficiency of last-mile logistics and facilitate reverse logistics; - digital twins to optimize the flow of resources throughout the supply chain, resulting in efficient delivery.
Menilik Pembatasan Kebebasan Beragama dan Berkeyakinan dalam Perkawinan Beda Agama di Indonesia
Authors: Widyawati Fransiska
Published: December 2023

Abstract: The right to marry and the right to practice a religion are fundamental human rights that are not mutually exclusive. The fulfilment of one does not necessitate the compromise of the other. However, in Indonesia, many couples from diverse religious backgrounds face complexities in exercising these rights due to the constraints
imposed by Marriage Law Number 1 of 1974, which does not explicitly accommodate interfaith marriages. According to this law, the legal recognition of a marriage necessitates a religious ceremony, and religious institutions often resist interfaith marriages. They typically urge couples from different religions to adopt a common faith to facilitate their acceptance into matrimony. This requirement often compels individuals to convert to their partner’s religion, thereby challenging their freedom of religion and belief. In the pursuit of a legally recognized marriage, individuals may find themselves coerced into relinquishing their religious freedom. This article examines the challenges faced in actualizing human rights and religious freedom in Indonesia within the context of interfaith
marriages. The methodology employed is Critical Discourses Analysis (CDA), a critical study based on text (in this case, Marriage Law No. 1/194) and context (random examples). Through critical analysis, this article posits that government regulations requiring legal recognition of marriages by religious institutions serve as an impediment to the fulfilment of religious rights and beliefs for citizens engaged in interfaith relationships. Consequently, this article advocates for amendments to the marriage regulations to actualize the human rights of freedom of religion
and belief.

Key words: Marriage, Human Rights, Indonesia, Marriage Law, Inter-religious Marriage
A COMPREHENSIVE STUDY OF DURA MATER BIOMINERALIZATION: MORPHOLOGICAL, CRYSTALLOGRAPHIC, AND IMMUNOHISTOCHEMICAL ASPECTS
Authors: Denysenko A. P. , Piddubnyi A. M. , Tkachenko I. A. , Shubin P. A. , Tarabarov S. I. , Moskalenko R. A.
Published: December 2023

Biomineralization is a process of formation of biominerals widespread among living organisms. This phenomenon occurs in the central nervous system in normal and pathological conditions. Typically, this can manifest age-related changes, and the prevalence of biominerals increases with age. At the same time, it can be a sign of pathology – tumour growth, dystrophy, metabolic disorders, etc. This work aims to study the morphological features of the dura mater with signs of biomineralization. In this work, we examined 30 samples of the dura mater with signs of biomineralization (group I) and 30 samples without these signs (group II) obtained during autopsies in the pathology department of the Sumy Regional Clinical Hospital. For the morphological characteristics of the dura mater, we used histological, histochemical and immunohistochemical methods, as well as scanning electron microscopy. Statistical processing of the results of the immunohistochemical study was carried out in the GraphPad Prism 8.0 statistical package using parametric and non-parametric research methods. To divide the samples into groups, we relied on the histological method – staining with hematoxylin-eosin. Histochemical methods (alizarin red staining, von Koss method) confirmed the presence of calcium compounds in the studied group. Van Gieson staining visualized the collagen fibres of the dura mater, and the PAS reaction did not reveal the presence of glycosaminoglycans in the mineral deposits. Immunohistochemical examination of the dura mater with antibodies against osteopontin revealed a significant difference between the study and control groups (p<0.001), confirming the critical role of osteopontin in the biomineralization process in this tissue. With the help of scanning electron microscopy, it was found that biominerals in the dura mater are represented by tens to hundreds of formations of various shapes (rounded, oval and irregular), varying from tens of nanometers to 50 micrometres. Their composition was analyzed using maps and spectra of energy-dispersive X-ray spectroscopy and most probably corresponded to calcium hydroxyapatite. So, the dura mater is characterized by biomineralization, manifested by the formation of microscopic calcium hydroxyapatite composites.
Neuroprotective effect of 2-ethyl-6-methyl-3-hydroxypyridine succinate on the sciatic nerve and its segmental centers in experimental paclitaxel-induced peripheral neuropathy
Authors: Herashchenko S. B. , Ostrovskyi M. M. , Kulynych H. B. , Markiv I. M.
Published: December 2023

Up to 60 % of patients suffer from the neurotoxicity of the chemotherapy drug Paclitaxel, namely paclitaxel-induced peripheral neuropathy (PIPN), during the treatment of breast cancer, ovarian cancer, and non-small cell lung cancer. Of these, up to 25 % of patients require modification of the paclitaxel treatment regimen, including dose reduction, delay, or discontinuation of therapy. Previous attempts to use neuroprotective agents in humans and in animal models have not shown sufficient efficacy in preventing or significantly reducing the manifestations of PIPN. The aim of our study was to study the effect of the neuroprotective agent 2-ethyl-6-methyl-3-hydroxypyridine succinate (HS) on the morpho-functional parameters of the sciatic nerve and its segmental centers in experimental PIPN. In the experiment, 56 white rats were used, which were injected intraperitoneally with Paclitaxel at a dose of 2 mg/kg of body weight 4 times after one day, after which the animals were divided into an experimental group – 24 animals that were injected with HS and a control group (24 animals, injection of water for injections). The method of studying mechanical allodynia was von Frey monofilaments, thermal hyperalgesia was studied by the hot plate test, and the electron microscopic examination was carried out according to generally accepted methods and studied with the help of a PEM-125 K electron microscope. The results of the hot plate test and the use of von Frey monofilaments showed that the use of HS reliably reduces manifestations of PIPN on the 7th, 14th and 28th days of the experiment. In rats treated with HS, destructive-dystrophic phenomena in the myelin nerve fibers of the sciatic nerve are less pronounced, and in individual fibers in the axon, phenomena of incomplete splitting of mitochondria with the formation of vacuoles filled with medium electron density contents are observed, and small young mitochondria are also visualized. During the first 28 days, we noted less pronounced destructive-dystrophic changes in the neurons of the spinal cord nodes, namely: chromatolysis of light and dark neurons and swelling of their cytoplasm, phenomena of neuronophagy in gliocytes, hypertrophy of certain areas of the myelin sheath. The results of the electron microscopic study are fully consistent with the data of neurophysiological studies and indicate the possibility of using HS as an effective neuroprotector in PIPN.
EXPEDITION TO ALAID AND EBEKO VOLCANOES (KURIL ISLANDS) IN SUMMER 2023
Authors:   Moscow State University M.V. Lomonosov, Bolshakov I.E. , Nuzhdaev A.A. ,   Institute of Volcanology and Seismology FEB RAS, Kuznetsov R.A. ,   Institute of Volcanology and Seismology FEB RAS, Anikin L.P. ,   Institute of Volcanology and Seismology FEB RAS, Kudryashova K.A. ,   St. Petersburg Mining University, Zhitova E.S. ,   Institute of Volcanology and Seismology FEB RAS
Published: December 2023

The results of field work at the active volcanoes Alaid and Ebeko, located in the northern part of the Kuril Island Arc, carried out in June−July 2023 are described. At Alaid volcano, the first survey of lava flows and fumarolic mineralization products of the 2022 eruption was carried out at various heights, including the summit, and geological sampling of the Taketomi cone and eruptive rocks of the eastern coast of Atlas Island was also conducted. An aerial photo and area temperature survey of the area occupied by the products of the 2022 eruption was undertaken at the summit of Alaid volcano using a high-precision quadrocopter equipped with a thermal imaging camera. At Ebeko volcano, mineral samples were taken from fumarole sites located on its eastern slope, and an aerial photo and area temperature survey were done.
MORPHOLOGICAL CHARACTERISTICS AND CHEMICAL COMPOSITION OF PLACER GOLD FROM THE KENGEVEY RIVER BASIN AND FIRST DATA ON ASSOCIATED PLATINUM-METAL MINERALIZATION (MAGADAN REGION)
Authors:   Institute of Volcanology and Seismology FEB RAS, Skilskaia E.D. , Kudaeva Sh.S. ,   Institute of Volcanology and Seismology FEB RAS
Published: December 2023

The paper presents the results of the study of typomorphic characteristics of placer gold of the tributaries of the Kengeveem River, Magadan region. Placer gold was studied by optical and scanning electron microscopy at the Institute of Volcanology and Seismology of the Far East Branch of the Russian Academy of Sciences. As a result, the first information on the morphology, internal structure and chemical composition of placer gold from the southeastern part of the Taigonos Peninsula was obtained. Three types of the gold were determined. The first type is dominant. The grains are chacterized by sub-ore morphology, with weak and medium degrees of roundness. Only Au-Ag is present in the composition of native gold, other macrocomponents were not found. The gold grade is 750–950 ‰. Some gold grains bear signs of hypergene transformation, expressed in the development of high-grade gold rims and intergrain veins. The second type of gold is represented by well-rounded lamellar extractions with a grade of 980–990 ‰. The third type is loose aggregates of secondary high-grade mustard gold. The obtained data allowed us to determine the different drift distances of native gold and to consider the low-sulfide epithermal Au-Ag mineralization and presumably far-distant gabbroids as the primary sources of gold.
TO THE 90th ANNIVERSARY OF THE ERUPTION OF THE TAKETOMI SIDE VOLCANO (ATLASOV ISLAND, KURIL ISLAND ARC)
Authors:   Institute of Volcanology and Seismology, Far Eastern Branch of the Russian Academy of Science, Rashidov V.A.
Published: December 2023

The eruption of the unique Taketomi side volcano, located on Atlasov Islandin the northern part of the Kuril island arc, started underwater and ended on land. It happened before people’s eyes and was essentially the formation of a new volcano. The newly formed side volcano was studied by famous Japanese scientists in 1933–1936, and from 1946 to the present day by Soviet and Russian researchers. The Taketomi side volcano continues to amaze with its landscapes and is actively visited by numerous tourists. Unfortunately, there is still not a single publication about people who have made a significant contribution to the study of this side volcano. This work is the first attempt to tell about them. In addition, based on available photographs, the destruction of the Taketomivolcano edifice from 1950s to 2020 is shown and, for the first time, existing inconsistencies cited in various publications describing the eruption of the volcano are highlighted.
HEALTH SAVING RESOURCE OF RESONANT SING-ING
Authors:   Kazan state institute of culture, Mirnaya Raushaniya Rafisovna
Published: December 2023

Achieving the utmost naturalness and freedom of sound formation, maximum expansion of the voice range, increasing the power of the voice, brightness and colorfulness of the timbre are the daily tasks of practical work of any vocalist. The resonant theory of singing is the most relevant and in demand system of representations of the relationship between the patterns of formation and per-ception of the singing voice (acoustic, physiological and psychological), allow-ing to achieve high aesthetic and vocal and technical qualities of the singing sound by revealing the resonant properties of the vocal apparatus. Vocal reso-nance (filling of cavities with air) determines strength, filtration, enrichment, expansion, improvement, intensification and prolongation of the singing sound through phonation, enhanced by the vocalist’s timbre. The result of using natu-ral resonance is the health and longevity of the singing voice.
Status of atmospheric air pollution in Ukraine prior to the full-scale russian invasion. Part 2: Pollutants total content according to the satellite data
Authors: Savenets M. V. , Nadtochii L. M. , Kozlenko T. V. , Komisar K. M. , Zhemera N. S.
Published: December 2023

The paper describes the main features of pollutant total content distribution over Ukraine that can be used as baseline air quality data observed before the full-scale russian invasion in Ukraine. The study is based on the data derived from the TROPOspheric Monitoring Instrument (TROPOMI) onboard of the Sentinel-5 Precursor (5P) satellite that indicates nitrogen dioxide (NO2), sulfur dioxide (SO2), carbon monoxide (CO) and formaldehyde (CH2O) levels. We defined the characteristics of pollutants spatial distribution with full coverage of Ukrainian territory. Despite the increasing role of automotive emissions, the most polluted air in Ukraine was still observed over large industrial cities and smaller settlements having the biggest thermal power plants (TPP). The high level of pollutants content over these locations negatively affects air quality in suburban and rural areas by the prevailing wind. They form relatively stable polluted spots over larger areas. Hence, main polluted areas include: Donetsk Region; territories in the central part of Ukraine along the Dnipro River and near the destroyed Kakhovka reservoir; Kharkiv and Zmiiv TPPs; Kyiv and Trypillia TPPs; and the territories in the western part, including Lviv, Dobrotvir and Burshtyn TPPs. The polluted air from these territories determines the air quality depending on a prevailing wind. In case of high wind speeds polluted air can be distributed from urban areas towards relatively clean territories such as Carpathian and Crimean Mountains, northern Polissia, and the Medobory National Park of Podillia. We determined quantitative parameters of wind speed and direction for every pollutant that causes higher total content over relatively clean territories. Pollutants dispersion in the atmosphere varies depending on a boundary layer height (BLH). It was found that NO2, CO and SO2 content significantly increased when the BLH was below 500 m over both urban areas and clean territories with no emission sources available. The inverse dependence on the BLH was identified for CH2O. This can be explained by a more intense photochemical production at higher altitudes. The detected baseline air pollution conditions can be used in order to assess the impact of the war on air quality in Ukraine and come up with relevant post-war development measures.
Topic «Unveiling Competitive Advantages: A Comprehensive Analysis through Market Mapping»
Authors: Le Chan Bao ngok
Published: December 2023

This comprehensive analysis delves into the intricate dynamics of the Fast-Moving Consumer Goods (FMCG) industry, employing a multifaceted approach to assess the competitive landscape. Utilizing both 2-factor and 7-factor competition models, the study scrutinizes the market positions and growth trajectories of 20 prominent companies over a specified period. In the initial exploration, the 2-factor model establishes FMX and WMT as formidable contenders, while ABT emerges as an outsider facing challenges. A subsequent shift in focus to the 7-factor model reveals nuanced reevaluations, positioning WMT as the industry leader, FMX as a strong contender, and ABT with a significantly elevated ranking. Additional entities, namely MDLZ, CHSCL, WKC, and PPA, are identified as outsiders in this extended model. It is crucial to note that the 'outsider' designation contextualizes their position relative to industry leaders but does not diminish their substantial market value. This in-depth examination contributes to a nuanced understanding of competitive forces within the FMCG sector, offering valuable insights for strategic decision-making.
Company’s value evaluation through modifying its capital structure with bonds and stocks issuance simulation using machine learning and statistical analysis approaches
Authors: Nazarova Daria Igorevna , Semina Natalia Sergeevna , Nikulin Leonid Romanovich
Published: December 2023

The present financial landscape is complexly woven with the interplay of financial instruments and technologies, reshaping the way companies manage their value. Financial instruments act as the cornerstone of capital structure, influencing cash flows and overall valuation. Meanwhile, financial technologies introduce innovation and efficiency via presenting unprecedented capabilities in assessing and forecasting the impact of these instruments on a company's worth. The ability to make timely decisions on resource allocation and capital raising is a key determinant of success in a rapidly evolving business landscape. Thus, the financial sector undergoes transformative changes, reshaping how companies navigate complexities and make informed decisions in an increasingly dynamic environment. The symbiosis of these elements is reshaping the future of finance, offering new avenues for creating and managing value in an interconnected world.
Possibilities to apply comparative approach to valuation for Russian companies
Authors: Gezha Alina Vladimirovna
Published: December 2023

This article considers the problems of applying the comparative approach to the valuation of Russian companies. The methods of comparative approach to business valuation are studied. PJSC Acron value by the method of companies – analogues is calculated. It is concluded that the method of companies – analogues with multiplicators is the most applicable for Russian companies and whole market.
The impact of geopolitical factors on company value
Authors: Nikulin Leonid Romanovich , Semina Natalia Sergeevna , Nazarova Daria Igorevna
Published: December 2023

In order to understand the influence of geopolitical factors on the value of the company the value of PJSC Sberbank will be estimated using dividend discount model and earning multiplier and after that compared with values of JPMorgan Chase and HSBC banks which will be calculated using same methods in order to estimate the discount that Russian bank will have in comparison with American and British banks that are supposed to have zero discount since those countries are considered as the most stable and economically developed in the world thus it makes sense to calculate discount rate based on their prices. Also, a regression model which will analyze factors that can affect the price of stocks of those banks will be considered, and if the results for Russian and Western banks are too different, it becomes possible to estimate the error (discount) which is applied when pricing Russian assets.
Assessment of the probability of bankruptcy of PJSC Lukoil
Authors: Smolenkova Ekaterina Aleksandrovna
Published: December 2023

The article describes bankruptcy issues and information on conducting an assessment of the probability of assessing the bankruptcy of companies. Based on the data from the accounting statements of the oil and gas company PJSC Lukoil, the probability of bankruptcy of the company was assessed using four bankruptcy forecasting models. The article presents the conclusions of the analysis, evaluates the success of the introduction of the financial policy of the company.