bluuebunny/crossref_metadata_2025 huggingface dataset:
The Language of Violence: Aggression as a Narrative and Thematic Device in Literature
Authors: Neupane Dasarath , Lourdusamy Arputhem
Published: January 2025

This paper, therefore, investigates the representation of aggression in English literature, taking into consideration thematic and narrative meaning in various periods and genres. This research uses selected literary works qualitatively to show how the manifestations of aggression through physical, psychological, and systemic violence have constituted a prism on which power, identity, gender dynamics, and social inequality have been discussed. The research shows how aggression develops the character, the plot, and reader involvement, even while it also raises moral and ethical questions. By locating aggression within both historical and cultural contexts, the research underlines its enduring relevance as a motif that reflects values and complexities of life. Results broaden the general view on aggression in literature by offering an insight into its manifold faces and impacts readers may get from it. This work thus encourages further investigations on the intersection of aggression with other themes and representations across a number of traditions.
Sources of differentiated EU integration
Authors: Ruszkowski Janusz
Published: January 2025

The aim of the research is to identify and classify the sources of differentiated EU integration, indicating their two groups. The first group consists of primary sources, inherent in the Member States, such as: motivations of states, different cultural, religious, historical or axiological identities of states, different legal traditions, as well as political differentiation in the Member States. The second group consists of secondary sources, because they result from the nature of the political system of the European Union and from the solutions of its subsystems: legal, institutional, processual or relational. The analysis is based on the neofunctional system of explanation and on the liberal intergovernmental theory. Neofunctional mechanisms can be observed in the dynamics of diversity of integration processes. Such dynamics will be examined on a territorial (geographical, subjective level) and objective level. Diversity has diffuse effects, located on the axis between the point indicating the risk of fragmentation and exclusion (spill-back) and, on the other hand, the point defining the moment of deepening integration and its expansion to new areas (spill-over). The ontological perception of differentiated integration also has a strong intergovernmental provenance, as it depends on the Member State. There are EU Member States that are more willing to engage in differentiated solutions, because they are less afraid of marginalisation and much more count on additional benefits from the effects of deepening cooperation
Plans of integration of the railway network in the Three Seas Initiative countries
Authors: Engelhardt Juliusz
Published: January 2025

The aim of the article is to discuss current investment projects of the countries located in the region between the Baltic Sea, the Black Sea and the Adriatic Sea, referred to as the Three Seas Initiative countries. The subject matter concerning new international railway connections in this region, especially that linked Poland with neighboring countries, is of decisive integration importance. Since in recent years in Poland there has been a lot of discussions about the large project of constructing the Central Communication Port (pl. Centralny Port Komunikacyjny, CPK), this project is a special point of reference, because its implementation in the future (at least the most important part of the expanded railway component) will primarily affect Poland's new international railway connections with Lithuania, Latvia and Estonia on the one side, and with Ukraine, Slovakia, the Czech Republic and Hungary on the other side. However, the projects of integration of the railway network will also influence countries far away from Poland: Finland – in the North, Slovenia and Romania – in the South. The research problem of the article is to indicate the significance of the analysed railway investments in the following dimensions: socio-economic, geopolitical, and defensive dimension. The solution to this problem will be sought mainly in the analysis of the concept of constructing a new railway line connecting Tallinn, Riga, Kaunas, Białystok, Warsaw and Berlin (called Rail Baltica) and in the plans of modernisation of other cross-border railway connections to the standard of high-speed railway lines. The main research method is a critical analysis of the official governmental strategic documents and available literature on the subject, as well as own observations. The content of the article allows readers to know about the basic directions of development of the railway network in the Three Seas Initiative countries
The Impact of COVID-19 Pandemic on the International Collaboration on Academic Papers in Mainland China: Taking Economics as an Example
Authors: Huang Sihui , Li Yinuo , Yuan Xilin
Published: January 2025

Examining the impact of the COVID-19 pandemic on the quantity and quality of international collaborative academic papers is one of the important issues in promoting the internationalization of academic research. Taking economics as an example, based on the data of international collaborative papers in mainland China for a total of four years (2018–2022) before and after the epidemic, this article analyses the outputs, the main collaborating countries, and the changes in quality of international collaborative papers in mainland China through bibliometric methods. Research shows that in the early times of the COVID-19 pandemic, there was a brief surge (or outbreak) in academic output and international collaboration. In the middle and later times, due to multiple impacts of the pandemic and technological blockade, the quantity and quality of international collaborative papers in China declined significantly, especially with developed countries, mainly the United States. The research suggests the necessity of continuing to promote the internationalization of academic research and promote academic innovation.
Data sovereignty and community engagement at the intersection of language and ecological knowledge: Lessons from two Wixárika (Uto-Aztecan) communities
Authors: Bierge Stefanie Ramos , Salvador Gabriel Pacheco , Cruz Tutupika Carrillo de la , McAlvay Alex C.
Published: January 2025

Indigenous languages and ecological knowledge are tightly interwoven and have been eroded in tandem in many parts of the world. To bolster or revitalize this cultural heritage, many Indigenous Peoples have worked with linguists and/or ethnobiologists, either from within or outside of their communities. Despite an increase in interdisciplinary projects at the intersection of these fields, there has been a limited exchange of best practices, ideas, and resources related to ethical and effective work with communities. Two areas where linguists and ethnobiologists have been innovative in parallel are data sovereignty and community engagement. While linguists often deposit data in large centralized archives with different levels of access to respect community preferences, equivalent archives, and graded access capabilities for ethnobiology are less common. At the same time, ethnobiologists have been experimenting with Traditional Knowledge Labels and Biocultural Labels to ensure that community preferences for information use accompany the data. For community engagement, tools such as ‘linguistic landscapes’ would be easily translated to ethnobiological projects, and community natural history collections could be synergistic with linguistic projects. Linguistics and ethnobiology share significant overlaps not only related to the classification and encoding of biological knowledge as well as in the need for methodologies that foster ethical engagement with local communities. Cross-communication between the two disciplines may lead to mutual benefit. In this paper, we outline approaches taken to address these issues by both fields, examine opportunities for mutual enrichment, and share experiences from our project with two Wixárika communities in West-Central Mexico.
Planting seeds for the future: Challenges and solutions for Cham traditional medicine in the context of Vietnam's rapid modernization
Authors: Quang Tuyen Dai , Dao Quyen Thanh , Nguyen Hoang Van
Published: January 2025

The present study is an investigation of the indigenous Cham community of Vietnam, descendants of an ancient civilization, and their efforts to preserve traditional forms of knowledge related to plant diversity and its applications for health and personal wellness. The study was conducted over two years through ethnographic fieldwork in two Cham villages and employs a mixed-methods approach, combining observation, interviews, and linguistic analysis. The findings reveal the challenges faced by the Cham people in preserving medicinal plant varieties and indigenous knowledge amid Vietnam's rapid modernization and economic reforms. The linguistic practices surrounding the cultivation of medicinal plants and the movement of local vendors between rural and urban environments for the sale of traditional medicine are analyzed. The findings emphasize the importance of the Cham language in safeguarding both cultural practices and livelihoods, contributing to the broader discourse on indigenous knowledge and conservation. This work serves as a foundation for further exploration into how the Cham's medicinal practices could inspire community-based tourism, offering new perspectives on addressing contemporary challenges and fostering sustainable development.
Baskets of wisdom: Bahnar basketry, folk taxonomies, and the maintenance of upland environmental intelligence in Vietnam
Authors: Trần Hoài  , A Bên  , A Hung  , Đỗ Trường Huy  , K. David Harrison
Published: January 2025

The backpack basket has become an iconic element of Highlanders’ culture in public media and cultural heritage representations in Vietnam. The dominant Vietnamese language in those domains has only one term, gùi, to denote the most common types of ethnic backpack baskets, despite each group creating very diverse basket types. The use of outside overgeneralized terms can potentially contribute to cultural stereotypes and consequently hide diverse Indigenous cultures and knowledge. Our research focuses on baskets of the Bahnar (or Ba Na) ethnic group in the Central Highlands of Vietnam. In this research, we explore the richness of the Bahnar cultural and environmental knowledge contained in their diverse types of baskets and narratives about basketry. Related folk taxonomies are evidence of how the Indigenous groups precisely classify the natural and cultural world they live in and interact with.
In the Kingdom of the Sick: Abjection, Mutuality, and the Afflicted in Recent Pandemic Fiction
Authors: Gauthier Tim
Published: January 2025

During a pandemic, the omnipresence of the virus dictates that we negotiate our proximity to illness. We are brought face-to-face with the abject (the infected, the dying, the dead) provoking disgust and fear, but also, significantly, recognition. Our initial (and sometimes violent) reaction reflects an entrenched refusal to recognize any similarity between ourselves and the abject. Quarantining and social distancing are proven and (somewhat) effective methods for containing the spread of disease, but they also solidify the distinction between the sick and the well. The drive for immunity – an exemption from that which threatens the community –is a salient feature of many contemporary pandemic fictions. At the same time, other works push against that impulse, accentuating the need for the communal – an assumption of mutual vulnerability. Authors of recent Covid-centric texts (Gary Shteyngart, Elizabeth Strout, Weike Wang) illustrate how individuals oscillate between the contradictory desires for community and immunity – for being both a part and apart. In contrast, Sarah Hall’s Burntcoat and Ali Smith’s Companion Piece highlight the transformative possibilities of coming to terms with abjection and recalibrate the community/immunity balance in the light of present or future pandemics.
Capítulo décimo primero: La crítica de la idea de la nada. Significado
Authors: Manzano Vargas Jorge
Published: January 2025

Manzano Vargas, Jorge. Capítulo décimo primero: la crítica de la idea de la nada. Significado. Este capítulo está dedicado a revisar la crítica que Bergson hizo a la idea de la Nada. Jorge Manzano hace gala de profundos y extensos conocimientos al problematizar y poner en relación, por una parte, el pensamiento de Bergson y, por la otra, elementos y autores clave de la historia de la filosofía. El texto se divide en cinco grandes apartados: La nada, la angustia y el optimismo bergsoniano; Alcance de la crítica; Los argumentos; La idea de la nada y la creación y, por último, La nada y los contingentes.
Pathogenesis and Update on the Management of Melasma
Authors: S Al Abadie Mohammed
Published: January 2025

Melasma is a disfiguring skin disorder characterised by brown or grey-brown patches on the skin, often affecting the face. It is frequently recalcitrant to treatment. Melasma treatment options vary in mode and effectiveness, including topical creams, laser therapies, and systemic medications. Despite the array of available treatments, achieving consistent and satisfactory results remains difficult, which necessitates ongoing research to develop safer and more effective therapeutic strategies for treatment of melasma. The aim of the article is to provide a comprehensive review of the current understanding of melasma's complex pathogenesis, as well as to examine and evaluate existing and emerging treatment options to guide clinical approaches for more effective and individualized management of melasma.
Genetically Engineered Mouse Model in Preclinical Anti-cancer Drug improvement
Authors: Haider Rehan
Published: January 2025

Genetically engineered mouse fashions (GEMMs) have grown to be essential equipment in preclinical anti-most cancers drug development. Those fashions are designed to duplicate precise genetic alterations discovered in human cancers, providing a more accurate illustration of tumor biology and therapeutic responses. GEMMs allow for the look at tumor initiation, development, and metastasis inside a physiologically relevant microenvironment, offering insights into mechanisms of drug resistance and cancer evolution. Importantly, GEMMs assist in evaluating novel therapeutics' efficacy and protection, mimicking human pharmacokinetics and pharmacodynamics more intently than traditional xenograft fashions. Their use helps the identity of predictive biomarkers, permitting a more personalized method for cancer remedy. Moreover, GEMMs are treasured for testing combination treatment plans, assessing capability synergistic consequences, and understanding the tumor's immune panorama in immunotherapy research. No matter their blessings, GEMMs face barriers, consisting of high costs and time-extensive improvement. Additionally, no longer all cancer mutations are difficult to replicate in mice. Nonetheless, persistent advances in genetic engineering techniques, including CRISPR/Cas9, are increasing the application of GEMMs in oncology studies. Via improving the translational relevance of preclinical research, GEMMs play a pivotal function in accelerating the invention and development of more powerful anti-most cancer treatment plans, in the end improving patient results.
Up to date data base about using of Meat as a functional food
Authors: A. Shaltout Fahim
Published: January 2025

A number of studies have attempted to show how the addition of the various ingredients, the vegetables, the fibres, the extracts, as well as the removal of the fats and the additives could transform the conventional perception of the meat and the meat products types into one of healthy living. This article examines potential future trends in the agrofood industry and provides an updated version of recent studies on the subject. It analyses the changes that have taken place in the traditional meat industry as the agrofood industry's global forces increasingly focus it on the development and manufacturing of the functional foods types.
Diagnostic importance of blood and bone marrow study in blood cancers.
Authors: Rahnemoon Ahmad Reza
Published: January 2025

We know bone marrow cells have distinctive cytological appearances that reflect the lineage and stage of maturation which these features may be disordered in disease specifically. That’s why, HSC mainly reside in BM and special environment or niche orchestrates HSC fate including their quiescence and proliferation cells in normal and abnormal situations extrinsically. On the one hand, in distinguishing a reactive lymphoid proliferation from a lymphoproliferative disorder requires to lymphocyte morphology for pleomorphic lymphocyte vs. a monomorphic population with a latter favoring a lymphoid malignancy. On the other hand, the clumps of abnormal cells could indicate the infiltration of metastatic tumor. Hence, the manual differentiation is key which means whether a myeloid or lymphoid leukocytosis is favored, the presence of increased blasts should prompt bone marrow examination with providing additional necessary help studies. In this case, along with correct enumeration of blasts and blast equivalent, we should be checked immature granulocytes, basophils and eosinophils as well as distinguishing dysplasia to identify myelodysplastic syndrome or leukemia as well.
A 53-year-old female with pancreatic serous cystadenoma
Authors: Boujguenna Imane
Published: January 2025

Serous cystadenoma of the pancreas is a cystic benign tumor composed of small cystic spaces lined by small cuboidal cells with clear cytoplasm. We report a new case of this entity in 53-year-old Moroccan woman, with no family history of tumor. She consulted for an abdominal pain revolving for 2 months. The clinical exam revealed an epigastric sensitivity with a general state preserved. An abdominal computed tomographic scan was performed and revealed the presence of multicyclic pancreatic tumor measuring 2.5x1.5. It was located in the isthmus of the pancreas. The patient had an isthmic pancreatectomy. Histologically the tumor was composed of variably sized cysts bordered by simple cuboidal, focally glycogen-rich epithelium. The stroma was variably collagenized and showed highly vascularized, delicate to broad fibrous septas. Thus, the diagnosis of primary serous cystadenoma of the pancreas was retained. Serous cystadenoma is an uncommon neoplasm that can be confused with malignancy.
Changes of Adipokines, Adipocytokines and С-reactive Protein in Patients with Visceral Obesity and Metabolic Syndrome
Authors: Ganeva Silviya
Published: January 2025

Adipocytes expresses under the cell surface numerous receptors and secrete many active molecules, named adipokines and adipocytokines.

The aim of the present study was to investigate the levels of adipokines- adiponectin and leptin, adipocytokines- interleukin -1(IL-1), interleukin -6 (IL-6), tumor necrosis factor – α (TNF-α) and C-Reactive protein (CRP) in sera of patients with metabolic syndrome (MS).

Patients and methods: 35 patients with MS (n1=35) and 35 healthy persons (n2=35) were included.

The adipokines- adiponectin and leptin, adipocytokines (IL-1), (IL-6), (TNF-α) and CRP were investigated by enzyme-linked immunosorbent assay (ELISA) in plasma. Two homeostatic models were: Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) and Homeostatic Model Assessment β% (HOMA-β%).

Results: Patients with MS had statistically higher BMI (n1= 35.52±7.2 vs. n2= 22.84±2.98kg/m2; р<0.05), waist circumference (n1=110.0±14.89 vs. n2= 82.87±8.2 sm; р<0.05), systolic (n1=126.71±17.19 vs. n2=119.0 ±7.93mmHg) and diastolic blood pressure (n1=84.14±9.81vs. n2=77.14±6.45mmHg), levels of basal fasting insulin (n1=12.22±6.4vs n2= 8.39±3.04mIU/l; p<0.05) and НОМА-IR (n1=2.69±1.48 vs n2=1.65±0.48; p<0.05) than nonobese controls.

Significantly higher levels of leptin (n1=33.58±14.6ng/ml vs. n2=21.55±.16.1 ng/ml; p<0.05), IL-1 (n1=18,46±4,34 pg/ml vs. n2=4,33±1,46pg/ml; p<0.05), IL-6 (n1=0.9±0.25 vs.n2=0.5±0.3 pg/ml; p=0.05), TNF-α (n1=2.49±1.17 pg/ml vs. n2=1,12±0,58pg/ml; p<0.05) and CRP (n1=8,24±1,48 g/l vs. n2=5,9±2,36g/l; p<0.05) were demonstrated among the patients with MS. BMI had positive correlation with leptin levels and negative correlation with adiponectin levels in group with MS. A positive correlation was found between the Il-1 levels and HOMA%B, as well as between Il-6 and CRP levels in patients with MS.

Conclusion: Patients with MS had elevated levels of adipokines, adipocytokines and CRP.
An Unusual cause of Chest pain and Dyspnea in an Elderly: Giant Intrathoracic Haital Hernia
Authors: Ronald Gomes Richmond
Published: January 2025

Giant hiatal hernias, generally seen at advanced ages, can rarely cause cardiorespiratory symptoms such as dyspnea and chest pain. Here, we aimed to present a case with a large hiatal hernia that largely protruded to intrathoracic cavity and caused dyspnea, particularly at postprandial period.We report a case of a 74-year-old female who presented with one month history of progressive shortness of breath and left sided chest pain. Upon arrival, the patient was found to be hypoxic with oxygen saturation 90% on room air. Physical examination also showed decreased breath sounds on left mid to basal lung with shifting of trachea and apex beat to right side. Plain radiograph demonstrated an increased opacity at the left lower lobe with retro-cardiac air fluid level; Subsequent computerized tomography of the chest revealed a giant hiatal hernia, containing stomach, duodenum, colon and spleen. This case highlights the giant hiatal hernia as an unusual cause of shortness of breath and chest pain, especially in elderly patients.
Fundamentals of using a Combined Diagnostic Approach for Covid 19 By RT-PCR and HR-CT Scan for early Case Recognition
Authors: Zafar Humaira
Published: January 2025

The emergence of more and more variants of COVID 19 and not ending pandemic is still a top most concerns around the Globe. The diagnosis of COVID19 is still a bit challenging. The asymptomatic phase during incubation period of disease or prodromal symptoms, mislead the clinician to early diagnose a case. Therefore this short communication was aimed to highlight a combined diagnostic approach for COVID by using HRCT scan chest and RT – PCR. This will be helpful for the clinician to early diagnose and timely manage a case, ultimately a step forward to contain this disease and its mortality. This commentary concluded that the sensitivity along with specificity of HR-CT scan and PCR varies. This variation could be due to many factors like mode of analysis, machines used for HR-CT scan or RT-PCR, technical handling. Therefore, though it become costly but a combined diagnostic approach should be used to early diagnose and manage COVID.
The Chemistry and Pharmacology of Tetrahydropyridines: Part 2
Authors: W. Ardley Tiffany
Published: January 2025

Tetrahydropyridines (THPs) have sparked notable interest as an auspicious heterocyclic moiety. Existing in distinct structural isomers including 1,2,3,4-tetrahydropyridine, 1,2,3,6-tetrahydropyridine, 2,3,4,5-tetrahydropyridine, its presence has been identified in both natural products and synthetic pharmaceutical agents. Many THP-containing compounds have been synthesized by the inspiration of known bioactive natural products and have been found to possess biologically active properties. For this reason, more innovative methods have been developed for the synthesis of substituted-tetrahydropyridine derivatives and their pharmacological activities have been determined. This review article is written to provide an overview which is a continuation of the former article by Redda et al. entitled, “The Chemistry and Pharmacology of Tetrahydropyridines”. This review aims to highlight the research progress accomplished thus far and to increase the database for structure activity relationship (SAR) studies. Special attention is given to the introduction of varied substituents onto the THP ring system and its redolent effect on their pharmacological properties, specifically as anti-inflammatory and anticancer agents. Thus, the use of SAR studies of newly reported THP derivatives will help shed light on the significance of utilizing THP-containing motifs as lead compounds in drug discovery and design.
Impact of the Introduction of the Mask Against COVID-19: a Narrative Review
Authors: Arias Uribe José Iván
Published: January 2025

The objective of this work was to identify the impact of the introduction of the mask against COVID-19. A review of the literature available in a specialized database, PUBMED, was carried out, which was adjusted to the guidelines framed in the PRISMA methodology [1]. Search equations were defined under the terms MeSH: human (MeSH D006801), COVID-19 (MeSH D000086382), masks (MeSH D008397), SARS-CoV-2 (MeSH D000086402) and equipment design (MeSH D004867), using the Boolean AND character. With these equations, articles published in 2020 were searched, recovering 676 records in total, choosing 82 that address the topic of interest and including in the final review 49 articles that met all the defined inclusion and exclusion criteria. The results suggest that the introduction of masks had a positive impact on reducing the risk of COVID-19 and the inappropriate use of masks is a risk factor.
Pharmacological Action of Clove (Syzygium aromaticum)
Authors: Srivastava Arun Kumar
Published: January 2025

Syzygium aromaticum or Clove has been used traditionally as a spice for thousands of years, and provides a rich and spicy addition to our favourite recipes. Cloves are also essential in the manufacturing of herbal medicine such as Indian Ayurvedic medicine and Chinese medicine. Phenolic compounds such as eugenol show antioxidant capacity and free radical scavenging activity. Constituents of the oil also include methyl amyl ketone, methyl salicylate, α and β-humulene, benzaldehyde, β-ylangene and chavicol.
Parathyroid Gland Disease: an Intricate Interaction between Physiology and Surgery
Authors: EP Weledji
Published: January 2025

Diseases are essentially disorders of physiological function. However, most patients with hyperparathyroidism are discovered incidentally during routine biochemical screening that includes a serum calcium determination. As patients with chronic renal failure now live longer as a result of dialysis and renal transplantation, secondary hyperparathyroidism is becoming more common. The management requires the understanding of the physiology of calcium homeostasis and implications in the human body. The aim of surgery is to remove the abnormal glands and leave the patient normocalcaemic. The familial multiple endocrine neoplasia (MEN) syndrome often present with parathyroid hyperplasia and screening by hormonal and biochemical analysis is mandatory once an index case has been identified.
The Effects of Probiotic Lactobacillus Acidophilus and Colchicine on The Control of Symptoms, Duration, And Disease Progression of Mild and Moderate Cases of Covid-19: A Randomized Controlled Clinical Trial
Authors: Ahmed Hassan Samar Osama
Published: January 2025

Background

Coronavirus disease 2019 (COVID-19) is a newly emerging human disease caused by a novel coronavirus, causing a global pandemic crisis. Probiotics and/or colchicine may be considered as options for treatment since they have anti-viral, anti-inflammatory, and immunomodulatory effects.

Objective

To assess the effectiveness of probiotic supplements (Lactobacillus acidophilus) and colchicine on symptoms, duration, and progression of mild and moderate cases of COVID-19 infection.

Methods

A three-arm randomized controlled clinical trial was carried out in the triage clinic of the family medicine department at Ain Shams University Hospitals on 150 participants who had been diagnosed as COVID-19 patients with mild and moderate severity. Patients aged below 18 years or above 65 years with any co-morbidities, pregnant or lactating females, and severe COVID-19 confirmed cases were excluded. Randomization was done by using sealed envelopes containing codes for intervention or control. Patients are followed up for improvement of their symptoms with no development of new symptoms over the course of two weeks.

Results

A total of 150 patients with mild and moderate severity of COVID-19 were enrolled in the study, 50 patients in each arm; around one third (34.7%) of the participants were aged between 29 and 39 years; one-quarter (24.7%) were aged between 18 and 28 years and 40.6% were aged 40 years and above. The mean duration of symptoms improvement was 12, 11 and 12 in the colchicine, probiotic, and control groups, respectively. Improvement of inflammatory markers over time occurred in each of the three groups, with no statistically significant difference between them.

Conclusion

Probiotic Lactobacillus acidophilus and colchicine shows no significant effect on the symptoms, duration, and progression of mild and moderate cases of COVID-19.
The Decryption of Bab1 Brucella Abortus Antigen- Bcap31 Receptor Binding in Oral Lactococcus Lactis Vaccine and Its Effect on Activation of Casp-8 And Il-10 For Immunogenicity
Authors: Doosti Abbas
Published: January 2025

Vaccination provides a proactive approach to controlling brucella infection in livestock. To; identify potential immunogenicity for brucella abortus vaccine candidates, in this study, we investigated the effect of the BAB1 Brucella Abortus antigen on casp-8 and IL-10 expression. Using GROMACS simulation and docking, we studied the BCAP31 receptor has a role in the immune response that is activated by BAB1 antigen. Then; Oral vaccinations with L. lactis transformed with pNZ8148 variants encoding for BAB1 (pNZ8148:BAB1) and Free-pNZ8148 were administered to mice.

Our results demonstrated an increased transcription levels of both the BCAP31, casp-8 and IL-1, supporting its potential as an efficient, safe, and effective immunogenicity vaccine candidate.

The findings from this research could someday lead to improved vaccines against illnesses caused by this organism, and also increased immunogenicity when it comes to treating related diseases. It could also mean a better understanding how organisms like B. abortus interact with their hosts at a molecular level. The; effects discovered here in regarding to casp-8 and IL-1 levels may also lead to further research into other products that BAB1 has on immunity and disease. Results of this article, we showed the role of Casp-8 and IL-1 activation through the effect of BAB1 antigen on BCAP31 receptor in Lactococcus Lactis vaccine immunogenicity and its potential for Brucella Abortus antigen detection.
Orthosiphon Aristatus Alleviates Skin Barrier Through Cytokines Regulation in DNCB- Induced Atopic Dermatitis Balb/C Mice Model
Authors: Handono Kusworini
Published: January 2025

Background: to analysed the effect of Orthosiphon aristatus on repairing skin lesions by regulating cytokines such as IgE, IL4, IL22, PGE2, NO in DNCB-induced Atopic Dermatitis BALB/C Mice Model

Methods: used BALB/C Mice which were sensitized by DNCB for 21 days to developed atopic dermatitis model. Mice were administered oral Orthosiphon aristatus extract once daily (on last 14 days after 7 days of sensitization). The doses given were divided into 6 groups: 17.5 mg/kgbw, 35 mg/kgbw, 70 mg/kgbw, and 140 mg/kgbw. We analysed the levels of cytokines such as IgE, IL4, IL22, PGE2 obtained from the blood. Additionally, we also measured morphological skin lesion severity to confirmed the amelioration effect clinically.

Results: Administration of Orthosiphon aristatus extract reduced the skin lesion severity in all intervention groups. The clinical improvement was supported by decrease of IgE, IL4, IL22, and PGE2 in dose dependent manner.

Conclusion: Orthosiphon aristatus alleviates DNCB-induced Atopic Dermatitis BALB/C Mice Model clinically through downregulating of IgE, IL4, IL22, PGE2, NO levels.
The COVID-19 Pandemic Waves: Comparative and Statistical Analysis of Their Dynamics
Authors: Nesteruk Igor
Published: January 2025

Record numbers of new COVID-19 cases and deaths registered in Japan and European countries in early 2022 aroused new questions about methods of overcoming the pandemic. The pandemic waves in Japan, Ukraine, USA, and Hong Kong in 2020, 2021, 2022 will be compared. Possible influence of testing and vaccination levels will be investigated.

Implications for Public Health.

Increasing the level of testing and adhering to quarantine restrictions for the entire population, including vaccinated people, can be recommended to reduce the negative consequences of the COVID-19 pandemic.
Presentation and Outcome of CSDH in Hospital
Authors: Gupta Sajag Kumar
Published: January 2025

Aim:To analyse the outcomes of surgical management in patients of chronic subdural hematoma. Study design: prospective

Place of study: Department of Neurosurgery, in tertiary care centre

Methodology: 65 patients of both genders with ages >18 years presented with chronic subdural hematoma were included. Patients detailed medical histories including age, sex and residence were recorded. Patients were categorized according to the Markwalder Grading System. CT scan was done before and after surgery and the discharge time. Outcomes were recorded according to the Glasgow coma scale.

Results: There were 57 (87.6%) male patients and 8 (12.3%) female patients. majority of them presented with headache (61.5%), followed by extremity weakness/paresis (52.3%). As Per, Markwalder grade on admission, 33 (50.7%) patients were in grade 1, 30 (46.1%) patients were in grade 2. The clinical picture at discharge was evaluated according to the Markwalder grade: 52 patients (80%) were grade 0, 2 patients (3%) grade 1, 9 patients (13.8%) grade 2

Conclusion: Headache and limb weakness are the most predominant presenting symptoms. The outcome correlates with the patient’s pre-operative neurological status, Glasgow Coma Scale and associated systemic diseases.
Beware the Plasmodial Infection Indicators: Plasmodium Falciparum Prevalence and Parasitaemia During two Years in Symptomless below 5 years old Children of Two Villages with long-Lasting Insecticide Treated Nets and two Villages without Nets in Angol
Authors: Carnevale P.
Published: January 2025

Forty parasitological cross-sectional surveys (CSS) were regularly done during two consecutive years in four villages around Balombo town (Benguela Province, Angola) to assess the influence of a full coverage with long lasting insecticide treated net (LLIN) PermaNet© 2.0 on plasmodial infection of under 5 years old symptomless children (“U5”).

Two villages received LLIN following a two steps process: 1rst year 1 LLIN per house; 2nd year: 1 LLIN per sleeping unit (= everything regularly used for sleeping) while two close villages remained as control for these two years.

Overall P. falciparum infections were microscopically observed in 1006 of the 2865 blood thick films made i.e., a plasmodial prevalence of 35.1%.

During these two years the plasmodial prevalence decreased significantly in the two LLIN furnished villages but also in the two control villages.

Therefore, the plasmodic index could not be considered as a relevant indicator to evaluate the parasitological efficacy of LLINs implemented in this study.

The gametocytic index did not significantly changed from year to year neither in LLIN villages nor in control villages and did not appear also as a relevant indicator in this study.

But on the other hand, the analysis of the evolution of the parasite load procured a crucial information with a significant decreased of the parasitaemia of U5 children in LLINs villages while it remained at the same level in control villages without any organized vector control operations.

Parasite load appeared as the relevant indicator showing the actual impact of LLIN in reducing the parasitaemia, and therefore the risk of malaria, in under five children in this area.
Current Status and Future Hopes of Medicine-Based Toward a Scientifically Approach to Mental and Behavioral Health Care
Authors: Heidari Alireza
Published: January 2025

The specialty of medication-primarily based fitness (the have a look at of thinking and behavior) is focused at the intersection of, and interaction between, bodily and behavioral fitness. Many medicinal drug-primarily based health thoughts docs are employed in medical settings and embedded inside healthcare teams. whilst the price of medication-based totally health mind doctors in healthcare has been well recorded/supported, books making/developing the (things that are given/work it really is carried out) of medicine-based health thoughts medical doctors in improving (as a great deal as feasible) results in crew-based totally healthcare is limited. In this newsletter, we provide a precis of the records of the field of medicine-based health (the examiner of wondering and conduct), as well as cutting-edge set up training wished matters and skills, and models of expert exercise inside the medical setting.
Experimental justification of the training model for highly qualified football players in the inductive mezocycle of the annual macrocycle
Authors: Hudyma Stepan , Perepelytsia Oleksandr , Boryachuk Andrii
Published: January 2025

The question of the construction and content of the training process of highly qualified players in recent years is at the stage of intensive development, which is connected with the availability of a large amount of information on the application of modern directions of optimization of the system of management and control of the training of athletes in the countries of the world with a developed system of the sports industry. The article highlights the results of the experimental substantiation of the model for building the training process of a football team of a high professional level in the engaging mesocycle of the preparatory period. Approbation of the developed training model took place in different climatic conditions. The purpose of the study is to experimentally substantiate the structure and content of the training process of highly qualified football players in an engaging mesocycle of annual training. Research material and methods. Methods: analysis and generalization of scientific and methodical literature and data presented on the Internet; pedagogical testing; methods of functional diagnostics; a pedagogical (sequential) experiment was conducted; methods of mathematical and statistical analysis. The study was conducted during 2021-2022 on the basis of the football club FC "Rukh" (Lviv), the team consisted of 30 qualified football players who participated in all stages of the study. Research results. A model of training in an engaging mesocycle was developed, which aimed to facilitate the process of organizing the training of highly qualified football players. It was implemented in different organizational conditions (mountain and sea climate). It was determined that in the conditions of the sea coast there is a greater increase in the results in the tests that characterize the manifestation of speed and speed-strength qualities, in mountain conditions – in the tests that reflect the general and special endurance. Main conclusions. The obtained positive changes in indicators of the functional state and physical fitness of qualified football players testify to the effectiveness of the proposed training model in the engaging mesocycle, regardless of the climatic conditions of the training process.
Model values of the integral assessment of the technical and tactical activity of highly qualified football players of different games
Authors: Kostiukevych Viktor , Pierluigi Traverso , Voitenko Serhii
Published: January 2025

Control and analysis of competitive activity is an important component of the athlete training system. One of the effective scientific and methodical approaches to the control of competitive activity is the integral assessment of technical and tactical activity.
The purpose of the study is to determine the model values of the integral assessment of the technical and tactical activity of highly qualified football players of various playing roles.
Research material and methods. The research was conducted during 2018-2023. The competitive activity of football players of national teams was analyzed. The scientific search was carried out on the basis of such methods as: theoretical analysis of literary sources, pedagogical observation of competitive activity, video analysis of competitive activity, methods of mathematical statistics.
Research results. The structure of the integral assessment of technical and tactical activity consists of six specific coefficients – intensity (KI), mobility (CM), aggressiveness (KA), efficiency (KE), martial arts efficiency (KEE), creativity (KK). Model values of the integral assessment of technical and tactical performance have been determined for highly qualified football players in various playing positions: for full-backs (n=20) – 5.26±0.77 points; for center-backs (n=20) – 5.11±0.54 points; for defensive midfielders (n=18) – 5.61±0.86 points; for wide midfielders (n=18) – 5.59±0.91 points; for inside forwards (n=18) – 5.71±0.77 points; and for strikers (n=18) – 4.90±0.84 points. Based on specific coefficients of technical and tactical performance, it has been established that the most dynamic gameplay is characteristic of defensive midfielders, wide midfielders, and inside forwards.
Conclusions. An integral assessment of technical and tactical activity most fully reflects the characteristics of highly qualified football players of various playing roles.
Структура техніко-тактичної діяльності студентської футбольної команди
Authors: Межвинський Артем
Published: January 2025

Football is one of the most popular sports among student youth. The training of qualified football players in the conditions of higher educational institutions requires a comprehensive approach, including control and analysis of competitive activity.
The purpose of the study is to determine the indicators and structure of the technical and tactical activity of the student football team.
Research material and methods. Qualified football players (n=22) - students of Vinnytsia State Pedagogical University named after Mykhailo Kotsiubynskyi – participated in the study. Sports qualification – 1st sports category, candidate for master of sports. The research was conducted during the competitive period of the first training cycle of qualified football players in the training macrocycle of 2023-2024. The research was carried out on the basis of the following methods: theoretical analysis and generalization of literary sources, pedagogical observation, video recording of competitive activities, methods of mathematical statistics.
Research results. The main indicators and structure of the technical-tactical activity of the student football team were determined: the total number of technical-tactical actions (TTD) was 720.4±57.71 with an efficiency ratio of 0.68±0.04. TTD structure: ball stops – 19.1%, ball passes – 37.9%, ball handling – 5.1%, opponent passing – 7.5%, ball clearances – 8.8%, ball interception – 18.9%, shots on goal – 2.7%. The average integral assessment score of the technical-tactical activities of the student football team is 4.72±0.38 points, with the following coefficients: intensity coefficient – 0.80±0.06 points, mobility coefficient – 1.46±0.30 points, aggression coefficient – 1.2±0.14 points, efficiency coefficient – 0.68±0.04 points, combat effectiveness coefficient – 0.54±0.09 points, and creativity coefficient – 0.22±0.08 points.
Conclusions. Control and analysis of the competitive activity of student football teams should be carried out on the basis of an integrated approach, taking into account the three modes of coordination complexity of performing TTD and holding, developing and aggravating passes of the ball. A component of the TTD structure of a football team is an integral assessment consisting of six specific coefficients: intensity, mobility, aggressiveness, efficiency, effectiveness of martial arts, creativity.
Nutritional value of fruits of different highbush blueberry cultivars
Authors: Perova I. B. , Eller K. I. , Baturina V. A. , Akimov M. Yu.
Published: January 2025

Highbush blueberry is one of the most common berry crops. The presence of polyphenolic compounds, especially anthocyanins and proanthocyanidins, determines the high nutritional value of blueberry fruits, as well as their potential health benefits for humans. A large number of studies have shown that regular highbush blueberry consumption can reduce the development and progression risk of several diseases caused by inflammation and oxidative stress. Moreover, it can positively affect the composition of the human intestinal microbiome. The work aims to study the content and composition of the main groups of polyphenolic compounds, organic acids, and sugars in fresh fruits of 7 blueberry cultivars (Coville, Elliott, Bluray, Bluegold, Goldtraube 71, Spartan, Rancocas). Fruits were collected from plants grown at the experimental cultivar testing site of the I.V. Michurin Federal Research Center. They were examined using modern analytical methods such as spectrophotometry, HPLC with photo-, refracto-, and mass-spectrometric detection. The content and profile of anthocyanins, proanthocyanidins, catechins, flavonols, hydroxycinnamic acids, organic acids, and sugars were examined in detail. In addition, the study determined the main specific chemotaxonomic features in the cultivar context. Drawing on the obtained results, cultivars with the highest anthocyanin and proanthocyanidin contents were identified. The article shows that the studied cultivars have potential for being used as raw materials to increase the nutritional value of human diets.
STUDY OF CATALYTIC POTENCY OF GREEN SYNTHESIZED SILVER DOPED CuO NANOPARTICLES WITH OXIDATION OF SERTRALINE HYDROCHLORIDE BY CHLORAMINE-T: A KINETIC AND MECHANISTIC INVESTIGATION
Authors: Arpitha M. K.
Published: January 2025

In this study, the concentration was on the catalyzed potency of green synthesized silver-doped copper oxide nanoparticles, and the oxidation of sertraline hydrochloride was performed in an aqueous acid medium using chloramine-T. Sustainable CuO nanoparticles doped with silver were synthesized using sol-gel. Utilizing scanning electron microscopy (SEM), ultraviolet-visible light (UV) analysis, and X-ray diffraction (XRD) to characterize the nanoparticles served to validate their successful production. With regard to [CAT], both catalyzed and uncatalyzed reactions follow first-order kinetics. Every kinetic parameter that is, the impact of variations in the concentrations of [STR], [H+], [Cl-], and so forth has been thoroughly examined and quantified. fractional order kinetics of a Nano catalyst made of copper oxide doped with silver. For both nano-catalyzed and uncatalyzed mediums, the dielectric constant has a favorable impact. Ionic strength has little bearing in either scenario. The reaction's stoichiometry was 1:1. The thermodynamic parameters were calculated by analyzing the kinetic runs at various temperatures, ranging from 293K to 313K. We examined the oxidation products. The suggested process yielded the rate law.