bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of a nutraceutical combining green tea extract, vitamin C, D, and zinc in patients with post-COVID conditions
Authors: Chian-Yi Liu , Chih-Yu Hsieh , Shih-Heng Chang , Shu-Chuan Wang , Chih-Cheng Lin
Published: May 2023

Tea and ascorbic acid have antioxidative and anti-inflammatory effects, and vitamin D and zinc have immunomodulatory effects. This study investigated the effect of a nutraceutical prescription combining these four nutrients on the blood biochemical markers and the modified C19-YRS questionnaires in patients who had recovered from COVID-19 disease for four months. Analysis of six markers associated with long COVID symptoms, i.e., INR, d-dimer, hs-CRP, NT-ProBNP, IL-6 and IgA, indicated that the nutraceutical could positively affect the values, especially for the inflammatory markers. The physician’s clinical observation and questionnaire analysis reported significant improvements in post-exertional malaise, sleep quality and overall health of the patients. These results suggested that formulated nutraceutical could not only reduces or eliminates the symptom of long COVID, but potentially also prevents reinfection.
Efficacy of Electrical Stimulation (ES) on Upper Limb Neurological and Functional recovery in Patients with Spinal Cord Injury: Protocol for a Randomised Controlled Trial v1
Authors: Obaidul Haque Md
Published: May 2023

Background: Spinal cord injury (SCI) causes physical disability including a deterioration of upper limb function that have a considerable impact on an individual’s functional status and independence. Electrical stimulation (ES) is the use of low-energy electrical pulses to induce muscular contraction, particularly in SCI patients. This study will determine the ES efficacy for upper limb functional and neurological improvement in SCI patients. Methods: Forty traumatic tetraplegic (TT) SCI patients will be recruited to this single blind clinical trial and will be randomly allocated to intervention and control group. The intervention group will receive a one-hour treatment that includes ES for 30 minutes and rest of the usual therapy for 4 weeks.The primary outcomes are Capabilities of Upper Extremity (CUE) Instruments, ASIA impairment scale (ASIA motor scores, ASIA sensory scores and neurological level). The secondary outcomes include Modified Ashworth Scale (MAS) and Manual muscle testing (MMT). ES will be placed on the extensor and flexor group of muscles of the wrist and elbow. Baseline will be performed at the commencement of participant recruitment in the trial and post-test will be performed after ten sessions and consequently twenty sessions of the intervention. The recruitment of participants started on October 1st, 2022, and the trial will be continued until the completion of recruitment of forty participants. Analysis: Data will be analysed based on the nature of data. Categorical data will be displayed using frequencies and corresponding percentages, whereas continuous data will be displayed using descriptive statistics. Intention-to-treat analyses will be carried out. Ethics and dissemination: The study has been evaluated by the Ethics Committee of Centre for the Rehabilitation of the Paralysed and Jashore University of Science and Technology, Jashore, Bangladesh. All participants will provide consent. The protocol will follow the SPIRIT (Standard Protocol Items for Randomized Trials) statement. All protocol requirements will be followed during the duration of the trial. Findings will be disseminated in peer- reviewed publications and presented at academic, national and international conferences. Trial registration number: [CTRI/2021/11/038271].
ABT263 (Navitoclax) Treatment in Mice v1
Authors: Davis Andrew
Published: May 2023

This protocol is for treating mice with the senolytic, Navitoclax, by oral gavage.
[RETRACTED] zsdasdas d v1
Authors: Frolov Vladimir
Published: May 2023

[RETRACTED]

ads asd
FAVIS: Fast and Versatile protocol for metabarcoding of bulk Insect Samples from large-scale diversity monitoring projects v1
Authors: Iwaszkiewicz-Eggebrecht Elżbieta
Published: May 2023

Here we describe a non-destructive metabarcoding protocol that is optimized for high-throughput processing of Malaise trap samples and other bulk insect samples. The protocol details the process from obtaining bulk samples up to submitting them for sequencing. It is divided into four sections: 1) Laboratory workspace preparation; 2) Sample processing - decanting ethanol, measuring the wet-weight biomass and the concentration of the preservative ethanol, performing non-destructive lysis and preserving the insect material for future work; 3) DNA extraction and purification; and 4) Library preparation and sequencing. The protocol is cost-effective and relies on readily available reagents and materials. For the steps that require expensive infrastructure – such as the DNA purification robots or sequencing center services – we suggest alternative low-cost solutions when possible. The use of this protocol yields a comprehensive description of the number of species present in a given sample, their relative read abundances and the overall insect biomass. To date, we have successfully applied the protocol to more than 7000 Malaise trap samples obtained from Sweden and Madagascar. The protocol allows one lab technician to process 180 samples (2x96-well plates when we include all negative and positive controls), from bulk insect catches to ready-to-sequence libraries, in 7 working days. In other words, samples collected over 1 week from 565 Malaise traps can be processed in one month, allowing the timely delivery of the results.
Exploiting ensemble learning and negative sample space for predicting extracellular matrix receptor interactions
Authors: Nath Abhigyan , Rathore Sudama , Singh Pangambam Sendash
Published: May 2023

The extracellular matrix (ECM) is best described as a dynamic three-dimensional mesh of various macromolecules. These include proteoglycans (e.g., perlecan andagrin), non-proteoglycan polysaccharides (e.g., hyaluronan), and fibrous proteins (e.g., collagen, elastin, fibronectin, and laminin). ECM proteins are involved in various biological functions and their functionality is largely governed by interaction with other ECM proteins as well as trans-membrane receptors including integrins, proteoglycans such assyndecan, other glycoproteins, and members of the immunoglobulin superfamily. In the present work, a machine learning approach is developed using sequence and evolutionary features for predicting ECM protein-receptor interactions. Two different feature vector representations, namely fusion of feature vectors and average of feature vectors are used within corporation of the best representation employing feature selection. The current results show that the feature vector representation is an important aspect of ECM protein interaction prediction, and that the average of feature vectors performed better than the fusion of feature vectors. The best prediction model with boosted random forest resulted in 72.6 % overall accuracy, 74.4 % sensitivity and 70.7 % specificity with the 200 best features obtained using the ReliefF feature selection algorithm. Further, a comparative analysis was performed for negative sample subset selection using three sampling methods, namely random sampling, k-Means sampling, and Uniform sampling. k-Means based representative sampling resulted in enhanced accuracy (75.5 % accuracy with 80.8 % sensitivity, 68.1 % specificity and 0.801 AUC) for the prediction of ECM protein-receptor interactions in comparison to the other sampling methods. On comparison with other three state of the art protein-protein interaction predictors, it is observed that the latter displayed low sensitivity but higher specificity. The current work presents the first machine learning based prediction model specifically developed for ECM protein-receptor interactions.
Konstellationen blau-grün-grauer Infrastruktur in der Klimaanpassung am Beispiel der Bewässerung von Öffentlichem Grün
Authors: Rauchecker Markus , Schramm Engelbert , Trapp Jan Hendrik , Stein Christian , Gunkel Michael
Published: May 2023

Die Regenwassernutzung zur Bewässerung von öffentlichem Grün kann mit gekoppelten blau-grün-grauen Infrastrukturen ermöglicht werden. Dazu sind nicht nur technische Fragen, sondern auch neue Akteurskooperationen und rechtliche Fragen wie Zuständigkeiten zu klären. Mithilfe einer Konstellationsanalyse zwischen Wissenschaftler/-innen und Praktiker/-innen werden neue Lösungswege für den Fall der Parkbewässerung mit Regenwasser von den Dächern angrenzender Häuser und Straßenwasser in einem Bestandsquartier erarbeitet. Die Übertragbarkeit auf andere Fälle ist durch die Verwendung eines hypothetischen Falls mit verallgemeinerbaren Setzungen gegeben.
The Effectiveness of Swale Drainage in Terms of Pollutant Removal and Rate of Infiltration
Authors:   Civil Engineering Programme, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia, Shammizi Nafahatul Qayyimah , Mohd Razali Siti Fatin ,   Smart and Sustainable Township Research Centre (SUTRA),  Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia
Published: May 2023

Swale drainage is a broad and shallow drainage that is able to filter runoff before flowing to the main drain and river. This study is focused on the effectiveness of the swale drainage compared to concrete drainage, in terms of pollutant removal and its relationship with the infiltration rate. The chosen site is at Astaka field, in Selangor.The water quality of the outflow was tested to determine the water quality classes when compared to the Interim National Water Quality Standards (INWQS) for Malaysia. Chemical oxygen demand (COD), total suspended solid (TSS), ammonia nitrogen, pH and turbidity are the five parameters that were tested in the water quality test. The study of infiltration rate of swale outflow was done by using the Mini Disk Infiltrometer and was compared with that of the field without swale. Swale proved to be effective to remove about 40%-60% TSS, 10-70% COD and 30-80% ammonia nitrogen compared to the regular concrete drain. The water turbidity of the outlet is higher than that of the inlet for both types of drainage. Results show that swale has negligible effects towards the pH value. The pH value obtained shows signs of alkalinity of the water outflow. The water quality of the outflow at swale outlet achieved Class II according to the INWQS for Malaysia. Swale at Astaka field had a rate of infiltration of 1.8-2 cm/hour which indicates a smaller rate than the field without swale.
An Application of Capacitance Proximity Sensor for Identification of Recyclable Materials
Authors:   Civil Engineering Programme, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia, Ahmad Irfana Kabir , Hidayah Harun Siti Nur ,   Civil Engineering Programme, Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia, Azmi Mohd Reza ,   Smart and Sustainable Township Research Centre (SUTRA),  Faculty of Engineering and Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia
Published: May 2023

Capacitive proximity sensor is often used in various industrial applications for contactless measurement of an object or target displacement and position. In this research, the capacitive proximity sensor is used for new alternatives in detecting recyclable materials specifically plastic and paper for aiding in the separation process. The detection of the sensor for this study is based on the permittivity values of each material where the sensor is adjusted according to the tested material permittivity. Several experiments have been conducted using different types of papers, plastics, and a combination of both materials for this study. At the end of the experiment, the sensor is able to detect a different type of paper and plastic. The sensor also able to detect the combination of both paper and plastic based on their difference in permittivity values. However, there are some limitations to this system such as the size, density, permittivity values, as well as the distance between both sensor and target are affecting the accuracy of the detection system causing the sensor to fail in identifying the samples.
Traffic Impact Assessment on a New Commercial Development in the Neighbourhoods of Ampang Town in Selangor
Authors:   Civil Engineering Programme, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia, Ismail Amiruddin , Mokhtar Nursyahirah Surianis ,   Civil Engineering Programme, Faculty of Engineering & Built Environment, Universiti Kebangsaan Malaysia, Bangi, Malaysia
Published: May 2023

Traffic impact assessment (TIA) on a proposed commercial development in the neighbourhoods of Ampang Town in Selangor was conducted. In this study, trip rate analysis and regression analysis were carried out to assess future traffic expected to be generated by the proposed new commercial development. Calculations of trips were based on the Malaysian Highway Planning Unit (HPU) Trip Generation Manual (TGM) Malaysia 2010 related to a category of proposed new commercial development. Before and after construction study on the proposed new commercial development at neighbouring critical intersections and roads was carried out to determine existing and projected traffic volumes. A Statistical Package for the Social Sciences (SPSS) software was used to analyse traffic growth rate. This procedure uses a growth factor in the traffic data to show an increase in demand for transport journeys in the future. Then, intersections and roads traffic performances were analysed using the Signalised and Un-signalised Intersection Design and Research Aid (SIDRA) software. Result of SIDRA analysis with traffic projection horizon of year 2026 shows deterioration in Level of Service (LOS) D at one of the existing main junctions leading to the proposed new commercial development. Finally, traffic improvements were proposed to address future impact of generated traffic caused by the proposed new commercial development. Consequently, this study has provided a framework for TIA preparation and would assist developers and local authorities in their decision making to meet all the requirements needed in the design and improvement of traffic flow.
Preservation of fertility in patients with testicular germ cell tumors: oncological, legal, and religious aspects
Authors: Mamizhev E. M. , Kemryugov T. Kh. , Aslanov B. I. , Nekrasov D. V. , Lavrinovich O. V. , Rumyantseva D. I. , Nosov A. K.
Published: May 2023

Survival rates for cancer patients continue to steadily increase due to improvement of effectiveness of current treatments. However, despite significant oncological results, one should not forget about the quality of life of this cohort of patients, in particular those who undergo gonadotoxic cancer therapy with development of premature ovarian failure in women and azoospermia in men. Preservation of fertility in both women and men with cancer is currently possible and should be integrated at all levels of cancer care. In this regard, the main purpose of this review is to consider the topic of fertility in men treated for cancer in the context of various aspects of human life.
Possibilities of treatment by radiofrequency denervation in coxarthrosis of various stages
Authors: Gorokhov Mikhail A. , Zagorodniy Nikolay V. , Kuzmin Vyacheslav I. , Sharamko Taras G.
Published: May 2023

The scientific review presents the treatment of coxarthrosis of various stages by the radiofrequency denervations technique. Full-text articles were searched in open electronic databases PubMed, eLibrary, CyberLeninka for the maximum possible time interval for the time interval from 1990 to 2023. Fifteen scientific articles were selected, in which 302 patients were treated with 489 radiofrequency denervations of the hip joint. The authors provide information about the state of the problem with special attention to the characteristics of various denervation protocols and justification of the choice of target points for exposure from the standpoint of anatomy and innervation of the hip joint. RCD is a modern, interventional, and effective solution to the main symptom, which is pain, according to numerous studies. The introduction of targeted effects on the articular branches of the locking and femoral nerves by radiofrequency denervation into the work of a practitioner can increase the period of remission of exacerbation of coxarthrosis and shorten the period of disability with a high level of intervention safety for the patient. Conducting further research on the role of radiofrequency denervation in coxarthrosis is critical.
Perbandingan Efektivitas Bacillus thuringiensis dengan Teknologi Ozon dalam pengendalian hama Spodoptera litura pada daun cabai (Capsicum annum)
Authors: Sutriono Sutriono , Zahar Intan
Published: May 2023

Abstrak. Hama ulat grayak (S. litura) merupakan salah satu hama yang menyebabkan daun berlubang tidak beraturan, sehingga mengganggu proses fotosintesis sehingga mengurangi produksi tanaman cabai sehingga perlu dilakukan penanganan hama. Tujuan dari penelitian untuk melihat perbandingan efektivitas B. thuringiensis dengan teknologi ozon yang dibangkitkan melalui reaktor Dielectric Barier Discharge Plasma dalam mengendalikan S. litura pada daun cabai di laboratorium.Metode penelitian terdiri dari beberapa tahapan yaitu (1) Pemeliharaan larva S. litura (2) Perlakuan dan Pengujian Ozon terhadap S. litura (3) Pengujian Toksisitas Isolat Bt terhadap S. litura. Parameter penelitian ini tentang mortalitas (%), dan perubahan persentase populasi (%). Perlakuan pemberian Bacillus thuringiensis sangat efektif dalam mengendalikan Spodoptera litura, hal ini terlihat pada 1 hari setelah aplikasi (HSA) sudah tampak hama ulat yang mortalitas (kematian), sedangkan perlakuan ozon mortalitas S. litura baru tampak pada 3 hari setelah aplikasi (HSA).  Hasil penurunan jumlah hama S. litura pada aplikasi bakteri B. thuringiensis lebih cepat di hari ke 4 hari setelah aplikasi (HSA) yaitu 0 persentase ulat yang hidup, sedangkan perlakuan ozon sampai hari ke 10 HSA masih tersisa 20 % hama S. litura.Comparison of the Effectiveness of Bacillus thuringiensis with Ozone Technology in Spodoptera litura pest control in chili leaf (Capsicum annum)Abstract. The armyworm pest (S. litura) is one of the pests that causes irregular perforated leaves, thus disrupting the photosynthesis process thereby reducing the production of chili plants so that pest management is necessary. The purpose of this study was to compare the effectiveness of B. thuringiensis with ozone technology generated through the Dielectric Barrier Discharge Plasma reactor in controlling S. litura on chili leaves in the laboratory.
The research method consisted of several stages, namely (1) Maintenance of S. litura larvae (2) Ozone treatment and testing of S. litura (3) Toxicity testing of Bt isolates against S. litura.The results of this study will reveal about mortality (%),and change in population percentage (%). The treatment with Bacillus thuringiensis was very effective in controlling Spodoptera litura, it was seen 1 day after application (HSA) the caterpillar pests showed mortality (death), while the ozone treatment of mortality of S. litura only appeared 3 days after application (HSA). The results of the decrease in the number of
S. litura pests on the application of B. thuringiensis bacteria were faster on the 4th day after application (HSA), namely 0 percentage of live caterpillars, while the ozone treatment until the 10th day of DSA still remained 20% of S. litura pests.
Pendugaan Kadar Patchouli Alkohol Pada Minyak Nilam Variasi Menggunakan Teknologi Near Infrared Reflectance Spectroscopy Dengan Metode Partial Least Square Regression
Authors: Dina Risqa Mutha , Safliany Farah Cikita , Nur Al Thahyat , Al-Annari Hagi , Ananta Dwipa Aby , Zulfahrizal Zulfahrizal
Published: May 2023

Abstrak. Minyak nilam merupakah salah satu minyak atsiri yang menyumbangkan devisa bagi negara. Komponen utama dalam minyak adalah Patchouli Alkohol (PA). Salah satu parameter yang menentukan kualitas minyak nilam adalah kadar PA. Semakin tinggi kadar PA maka  kualitasnya semakin baik dan harganya semakin tinggi. Tujuan dari penelitian ini adalah memprediksi kadar PA minyak nilam Aceh hasil fraksinasi dengan cepat dan tepat menggunakan teknologi NIRS dengan metode partial least square regression (PLSR) menggunakan pretreatment Mean Normalization (MN). Hasil penelitian menunjukkan bahwa PLSR mampu memprediksi kadar patchouli alkohol dengan menghasilkan model yang tergolong good prediction accuracy. Prediksi model akurasi terbaik dari perlakuan pretreatment MN dengan hasil dengan latent variable 5, nilai residual predictive deviation (RPD) sebesar 2,71, nilai koefisien determinasi (R2) sebesar 0,85, nilai koefisien korelasi (r) sebesar 0,92, nilai root mean square error calibration (RMSEC) sebesar 4,28.Estimation of Patchouli Alcohol Content in Variation of Patchouli Oil Using Near Infrared Reflectance Spectroscopy Technology with Partial Least Square Regression MethodAbstract. Patchouli oil is one type of essential oils that protects foreign exchange for the country. The main component in the oil is Patchouli Alcohol (PA). One of the parameters that determine the quality of patchouli oil is the PA content. The higher the PA content, the better the quality and the higher the price. The purpose of this study was to predict the PA content of fractionated Aceh patchouli oil quickly and precisely using NIRS technology with the partial least square regression (PLSR) method using Mean Normalization (MN) pretreatment. The results showed that PLSR was able to predict patchouli alcohol levels by producing a model that was classified as having good predictive accuracy. The best accuracy prediction model of the MN pretreatment handling with results with a latent variable of 5, the residual predictive deviation (RPD) value about 2,71, the coefficient of determination (R2) is 0,85, correlation coefficient (r) 0,92, and the value root mean square error calibration (RMSEC) of 4,28.
Positive impacts of integrating flaxseed meal as a potential feed supplement in livestock and poultry production: Present scientific understanding
Authors: Rajan Athira , V M Devika , Shabana Aysha , Krishnan Nayana , N Anil Krishnapriya , Krishnan Rohith , Y Baby Shajini , S Dev Bhadra , J Adinan , S Meenakshy , V R Amrithendhu , Chakraborty Sandip , Chopra Hitesh , Dey Abhijit , Sharma Anil K , Dhama Kuldeep , Chandran Deepak
Published: May 2023

When it comes to food and fiber production, flaxseed (Linum usitatissimum) has been around the longest. Oil makes up over 41% of a flaxseed's total weight; of that, more than 70% is polyunsaturated. Protein, dietary fiber, α-linolenic acid (ALA), flaxseed gum, and many other beneficial compounds are abundant in flaxseed meal (FSM). There is as much as 30% crude protein in FSM. Therefore, FSM can serve as a source of excellent protein for livestock. FSM increases the efficiency and effectiveness of livestock and poultry farming. FSM can be used as an essential protein feed component in cattle and poultry farming, boosting production and profitability. Because it contains anti-nutritional ingredients such as cyanogenic glycosides, tannins, phytic acid, oxalic acid and an anti-vitamin B6 factor, the use of FSM in livestock and poultry diets is restricted. Animal nutritionists have recently shown a growing interest in reducing anti-nutritional elements and boosting FSM's nutritional value. Recently, fermented FSM has been used to feed cattle and poultry; hence its dietary benefits have not yet been fully assessed. The present article, therefore, addresses the chemical make-up, bioactive components, anti-nutritional aspects, and positive impacts of FSM in livestock and poultry production.
Optimization of protein extraction from "Cam" rice bran by response surface methodology
Authors: Loan Le Thi Kim , Minh Quoc Ha , Minh Thuy Nguyen , Nhung Nguyen Thanh , Xuan Tran Dang , Duong Vu Xuan , Trung Khuat Huu , Minh Le Hoang Nhat , Khanh Tran Dang , Thu Ha Tran Thi
Published: May 2023

"Cam" rice bran was considered a waste product from rice, which is rich in natural compounds and protein owing to its outstanding nutritional value. This study aimed to establish an optimization model for extracting protein from rice bran, with two responses: extraction yield (%) and protein content (%). The variable parameters included were pH (8.5-9.5), stirring time (3.5-4.5 h), and enzyme incubation temperature (85-95°C). The coefficient of determination for both models were above 0.95, indicating a high correlation between the actual and estimated values. The maximum extraction yield and protein content were achieved when the conditions were set at pH of 9.02, stirring time of 4.02 h, and extraction temperature of 90.6°C. Under these optimum conditions, the predicted protein extracted from rice bran was 43.03% (moisture <13.0%), with an extraction yield of 15.9%. The findings of this study suggested that this protocol can enhance the utilization of rice bran and might be employed on a large scale in the food industry to exploit the nutritional source.
An Integrative Approach Towards Recommending Farming Solutions for Sustainable Agriculture
Authors: Ghuriani Veena , Wassan Jyotsna Talreja , Deolal Pragya , Sharma Vidushi , Dalal Dimpy , Goyal Aditi
Published: May 2023

Sustainable Agriculture is rapidly emerging as an important discipline to meet societal needs for food and other resources by adopting paradigms of conserving natural resources while maximizing productivity benefits. This paper proposes an integrative methodological approach for critically analyzing Precision Farming (PF) paradigms and Zero Budget Natural Farming (ZBNF), providing sustainable farming solutions and achieving productivity and profitability. This paper analyses the productivity of crops in PF using various machine learning (ML) algorithms based on different soil and climatic factors to identify sustainable agricultural practices for maximizing crop production and generating recommendations for the farmers. When implemented on the collected dataset from various Indian states, the Random Forest (RF) model produced the best results with an AUC-ROC of 95.7%. The Juxtaposition of ZBNF and non-ZBNF is evinced. ZBNF is statistically (p<0.05) observed to be a cost-efficient and more profitable alternative. The impact of ZBNF on soil microbial diversity and micro-nutrients is also discussed.
Growth and development patterns in Mustard (Brassica spp.) as influenced by sowing time
Authors: Chowhan Sushan , Islam Majharul , Rana Md. Shohel , Khan Nazmul Alam , Jahan Ali Md. Khan , Ahmed Nasir Uddin , Rahman Md. Moshiur
Published: May 2023

Mustard is Bangladesh's leading oil crop, produced only during the winter (rabi) season. The sowing date is a key factor determining mustard's optimum growth and development. Because of global warming, gradual changes in season and weather parameters over time is creating a challenge in mustard cultivation. Thus, the present investigation assessed the role of different planting dates on several modern mustard varieties to disclose the optimum growth indicators necessary for elevated biological yield (BY) and harvest index (HI). Three planting times, viz. 31st October (D1), 10th November (D2),  20th November (D3) and six varieties viz. Binasarisha-4 (V1), Binasarisha-9 (V2), Binasarisha-10 (V3), BARI Sarisha-14 (V4), BARI Sarisha-16 (V5), BARI Sarisha-17 (V6) were put on a replicated factorial randomized complete block design (RCBD) during rabi 2019 at BINA Sub-station farm, Magura. At the final harvest stage, outcomes depicted that highest and lowest total dry mass (g/plant) was produced by treatment D3× V5 (64.03) and D1× V1 (15.34), maximum and minimum absolute growth rate (mg/plant/day) by D1× V5 (2389.10) and D2× V1 (184.50), most and least relative growth rate (mg/g/day) in D1× V4 (53.34) and D2× V1 (3.55), maximum and least crop growth rate (g/m2/day) with D1× V3 (55.60) and  D3× V4 (20.04). BY was the peak (8.13, 8.71, 8.77 t/ha) under all plantings (D1, D2, D3) with V5 variety, but HI (44.96%) was most in variety V4 with D2 sowing. Therefore, correlation studies showed a significant positive relationship between biological yield and harvest index. Overall, BARI Sarisha-16 performed well in all three sowing times, and remarkably, BY was rising with delayed planting in the case of Binasarisha-9, Binasarisha-10, and BARI Sarisha-14. This implies that delayed planting might not hamper yield but boost yield to some extent.
Contraceptive efficacy and antioxidant potential of Leptadenia reticulata bark extracts in male albino rats
Authors: Kanwar Nisha , Thakur Ravindra Singh , Saran Ram Prakash , Purohit Ashok
Published: May 2023

Birth control measures available are primarily for women which are hormonal supplements that are increasing cancer risks and reproductive health issues. Male contraceptive options are effective and available, i.e. barrier methods and vasectomy. Condoms are failure-prone and single-use, while a vasectomy is a permanent sterilization method done surgically, and reversion is not always successful and expensive. A promising oral male contraceptive drug candidate is yet to be discovered. This study investigated the contraceptive efficacy and antioxidant potential of various extracts of Leptadenia reticulata bark in male rats. To study the effects of various extracts (ethanolic and petroleum ether) of L. reticulata bark in male rats, oral administration at the dose level of 250 mg/kg body weight/ day was done for 60 days. Observations were made for body and organ weight, hematology, serum biochemical chemistry, testosterone and antioxidants, lipid profile, sperm parameters (density and motility) and histological changes (reproductive organs). As compared to control in treated groups (TP and bark petroleum ether extract), a significant reduction (P ≤ 0.001) was perceived in sperm motility and density, as well as reproductive organ weight, serum testosterone, and serum antioxidant parameters like SOD. Histological observations revealed arrest in spermatogenesis and reduced seminiferous tubule diameter, mature Leydig cells, secondary spermatogonia, and spermatids which caused a substantial increase in LPO and GSH. From the research findings, it can be concluded that bark petroleum ether extract of L. reticulata possesses contraceptive potential in male albino rats and can serve as a safe and reversible oral contraceptive for males.
A Study of the Photodegradation Carbofuran and its Metabolites in Paddy Water Samples
Authors: Haji Baharudin Nurul Syuhada , Ahmad Harlina
Published: May 2023

Rice fields are one of the agricultural sectors in Malaysia that are heavily pesticide-treated. This study aimed to determine how carbofuran degrades in paddy water and how carbofuran metabolites such as carbofuran-phenol and 3-keto carbofuran reacted during the degradation. The experiment was conducted in two distinct conditions: the first water sample was exposed to sunlight, while the second water sample remained in the dark. During the 56 days of observation, the study discovered carbofuran decomposed slowly in both conditions. The water sample exposed to sunlight showed a faster degradation rate (0.04/day carbofuran) than the water kept in the dark (0.0186/day). The results also demonstrated that photolysis and hydrolysis enhanced the carbofuran degradation in the water. Both 3-keto carbofuran and carbofuran-phenol were detected as metabolites with low concentration levels, ranging from 0.03±0.301 to 0.23±0.142 ppm. These metabolites are considered 'emerging pollutants' as they can be detected in the environment and may post-treat as much as the parent compounds themselves. Hence, this study is trying to fill the research gap to assess the route and rate of carbofuran and its transformation products.
The Effect of Titanium Dioxide Nanoparticles on Haematococcus pluvialis Biomass Concentration
Authors: Mahendran Manishaa Sri , Wong Ling Shing , Antony Dhanapal Anto Cordelia Tanislaus , Djearamane Sinouvassane
Published: May 2023

The increased release of Titanium dioxide nanoparticles (TiO2 NPs) into the aquatic ecosystem is caused by the augmented utilization of nanoparticles in personal care and household products. This has resulted in the contamination of marine, aquatic, and ground water resources, causing adverse impacts on the biota and flora, both in vivo and in vitro. The main purpose of this research was to examine the negative impacts of TiO2 NPs on the bioaccumulation of Haematococcus pluvialis. The interaction and buildup of  TiO2 NPs on H. pluvialis were studied using scanning electron microscopy (SEM). The exposure of H. pluvialis to TiO2 NPs with increasing concentrations (5–100 μg/mL) and time intervals (24 h to 96 h) impacted the biomass concentration of the microalgae. The SEM images provided evidence of changes in characteristics and impairment of the exterior of exposed cells. The findings revealed that the exposure of H. pluvialis to TiO2 NPs resulted in a decline in biomass, which was dependent on the concentration and duration of exposure. The most severe adverse effects were observed after 96 hours of exposure, with a reduction of 43.29 ± 2.02% of biomass concentration. This study has demonstrated that TiO2 NPs harm H. pluvialis, as evidenced by the negative impact on algal biomass resulting from the binding and buildup of these particles on microalga H. pluvialis. To sum up, the decline in algal growth is caused by the accumulation and interaction of TiO2 NPs on microalgae scoring the adverse effects on the growth of H. pluvialis by TiO2 NPs. The findings of this study call for novel screening methods to detect and eliminate TiO2 NPs contamination in aquatic sources used for the cultivation of microalgae which may otherwise pose delirious effects to the consumers.
Voice Recognition Systems in the Cloud Networks: Has It Reached Its Full Potential?
Authors: Bodepudi Anusha , Reddy Manjunath , Thodupunori Swetha Reddy , Mandapuram Mounika
Published: May 2023

Voice recognition software enables computer users to use keyboards instead of only entering text using their voices. The medical and legal communities have both reported some success with speech recognition technology, even though the library literature is relatively mute on voice recognition technology. Voice-recognition technology can take over typing for someone who cannot do so due to a physical disability. Voice recognition may still be in its infancy, but it is advancing quickly and becoming more accurate, and it is well worth the investment of money, time, and effort required to learn it. Speech recognition artificial intelligence apps have seen a significant increase in numbers in recent years. Businesses increasingly rely on digital assistance and automated support to rationalize their offerings. Voice assistants, intelligent home appliances, search portals, and similar technologies are only a few instances of the widespread use of voice recognition. The research investigates the theory that one of the primary benefits of using a speech recognition system is that it enables the user to continue working on other tasks simultaneously. The user can direct their attention to observation and manual activities while maintaining control of the device using voice input commands. In addition, the study's findings indicate that voice recognition is an additional type of speech recognition in which a source sound is identified and matched to an individual's voice. For instance, Apple's Siri and Google's Alexa use AI-mechanized voice recognition to provide speech or text back support. On the other hand, voice-to-text programs such as Google Dictation translate words that are dictated to them as text.
Study on 3D printing process of continuous polyglycolic acid fiber-reinforced polylactic acid degradable composites
Authors: Aihemaiti Patiguli , Jia Ru , Aiyiti Wurikaixi , Jiang Houfeng , Kasimu Ayiguli
Published: May 2023

A continuous polyglycolic acid (PGA) fiber-reinforced polylactic acid (PLA) degradable composite was proposed for application in biodegradable load-bearing bone implant. The fused deposition modeling (FDM) process was used to fabricate composite specimens. The influences of the printing process parameters, such as layer thickness, printing spacing, printing speed, and filament feeding speed on the mechanical properties of the PGA fiber-reinforced PLA composites, were studied. The thermal properties of the PGA fiber and PLA matrix were investigated by using differential scanning calorimetry (DSC) and thermogravimetric analysis (TGA). The internal defects of the as-fabricated specimens were characterized by the micro-Xray 3D imaging system. During the tensile experiment, a full-field strain measurement system was used to detect the strain map and analysis the fracture mode of the specimens. A digital microscope and field emission electron scanning microscopy were used to observe the interface bonding between fiber and matrix and fracture morphologies of the specimens. The experimental results showed that the tensile strength of specimens was related to their fiber content and porosity. The printing layer thickness and printing spacing had significant impacts on the fiber content. The printing speed did not affect the fiber content but had a slight effect on the tensile strength. Reducing the printing spacing and layer thickness could increase the fiber content. The tensile strength (along the fiber direction) of the specimen with 77.8% fiber content and 1.82% porosity was the highest, reaching 209.32 ± 8.37 MPa, which is higher than the tensile strength of the cortical bone and polyether ether ketone (PEEK), indicating that the continuous PGA fiber-reinforced PLA composite has great potential in the manufacture of biodegradable load-bearing bone implants.
Developing a bioink for single-step deposition and maturation of human epidermis
Authors: Chai Ruth Jinfen , Wong Wan Ling , Beh Cyrus Weijie
Published: May 2023

Patients with severe burns, which cause extensive damage to their skin, require rapid intervention to prevent life-threatening hypothermia, infection, and fluid loss. Current treatments typically involve surgical excision of the burned skin and reconstruction of the wound with the aid of skin autografts. However, there is a lack of donor site in the most severe cases. While alternative treatments such as cultured epithelial autografts and “spray-on” skin can allow much smaller donor tissues to be used (and hence reduce donor site morbidity), they present their own challenges in terms of fragility of the tissues and control of the cell deposition, respectively. Recent advances in bioprinting technology have led researchers to explore its use to fabricate skin grafts, which depend on several factors, including appropriate bioinks, cell types, and printability. In this work, we describe a collagen-based bioink that allows the deposition of a contiguous layer of the keratinocytes directly onto the wound. Special attention was given to the intended clinical workflow. For example, since media changes are not feasible once the bioink is deposited onto the patient, we first developed a media formulation designed to permit a single deposition step and promote self-organization of the cells into the epidermis. Using a collagenbased dermal template populated with dermal fibroblasts, we demonstrated by immunofluorescence staining that the resulting epidermis recapitulates the features of natural skin in expressing p63 (stem cell marker), Ki67 and keratin 14 (proliferation markers), filaggrin and keratin 10 (keratinocyte differentiation and barrier function markers), and collagen type IV (basement membrane protein involved in adherence of the epidermis to the dermis). While further tests are still required to verify its utility as a burn treatment, based on the results we have achieved thus far, we believe that our current protocol can already produce donor-specific model for testing purposes.
Wall shear stress during impingement at the building platform can exceed nozzle wall shear stress in microvalve-based bioprinting
Authors: Nasehi Ramin , Aveic Sanja , Fischer Horst
Published: May 2023

It is well known that in microvalve-based bioprinting, the cells are subjected to wall shear stress, which can negatively affect their viability rate. We hypothesized that the wall shear stress during impingement at the building platform, hitherto not considered in microvalve-based bioprinting, can be even more critical for the processed cells than the wall shear stress inside the nozzle. To test our hypothesis, we used fluid mechanics numerical simulation based on finite volume method. In addition, viability of two functionally different cell types, HaCaT cell line and primary human umbilical vein endothelial cells (HUVECs), embedded in the cellladen hydrogel was assessed after bioprinting. Simulation results revealed that at low upstream pressure the kinetic energy was not sufficient to overcome the interfacial force for droplet formation and detachment. Oppositely, at relatively mid upstream pressure, a droplet and a ligament were formed, whereas at higher upstream pressure, a jet was formed between nozzle and platform. In the case of jet formation, the shear stress during impingement can exceed the wall shear stress in the nozzle. The amplitude of impingement shear stress depended on nozzle-toplatform distance. This was confirmed by evaluating cell viability which revealed an increase of up to 10% when increasing the nozzle-to-platform distance from 0.3 to 3 mm. In conclusion, the impingement-related shear stress can exceed the wall shear stress in the nozzle in microvalve-based bioprinting. However, this critical issue can be successfully addressed by adapting the distance between the nozzle and the building platform. Altogether, our results highlight impingement-related shear stress as another essential parameter to consider in devising bioprinting strategies.
Problematika Perusahaan Grup: Bentuk dan Potensi Praktik Monopoli dan Persaingan Usaha Tidak Sehat
Authors: Jayusman Dandi , Setianingrum Reni Budi
Published: May 2023

The development of group companies today is an implication of the globalization era which makes business competition more open and free and at the same time can plunge business actors into monopoly practices. The aim of this research is to analyze the problems of group companies in the Indonesian legal system and to analyze forms of monopolistic practices and unfair business competition through the business strategy of group companies (groups). While the method used is the normative legal research method using statutory approaches, case approaches, and conceptual approaches. The results of this study indicate that the problems of group companies in Indonesia occur due to the regulation based on the 2007 UUPT using a single company approach, which legally recognizes that the parent company and subsidiaries in group companies are independent. The forms of monopolistic practices that are likely to be carried out by group companies are cross-share ownership, discriminatory practices and price fixing through multiple positions. This is an implication of the parent company's controlling power and full dominance in determining the policies and business activities of its subsidiaries.
Unstable distal radius fractures fixation with a 2.4 mm volar variable-angle locking plate: radiological and functional assessment
Authors: Chawla Sumit , Gupta Amit , Pasupuleti Akhil , Karnati Ashok Kumar Reddy , Gupta Mallika
Published: May 2023

Background: The main objective of this observational study was to evaluate the functional and radiological outcome of variable angle volar plates in intra-articular distal end radius fractures.
Methods: Patients with distal end radius fractures (AO type 3C) treated operatively between Jan 2020 and Dec 2020 and then followed up for at least 12 months. A total of 32 patients (11 men and 21 women) with a mean age of 51.9 years were included in the study. The functional outcome was assessed by using modified Mayo wrist score (MMWS), disabilities of the arm, shoulder, and hand (DASH) score, wrist range of motion (ROM) and grip strength relative to the uninjured side and radiological assessment of radial height, volar tilt, and radial inclination.
Results: MMWS and DASH scores improved postoperatively over time. Signs of radiographic union started around 12 weeks after surgery. The most common complication observed was finger and wrist stiffness, which was resolved with active wrist and finger movements. Non-union or hardware-related complications/ late complications such as tendon irritation/attrition were not observed with variable angle volar locking plates.
Conclusions: Distal end radius fracture fixation with variable angle plate gives favourable radiological and clinical outcomes. These results can be owed to features such as low profile, variable locking, anatomical design and implant biomechanics. The surgeon determined angulation of the distal row of screw fixation may decrease the incidence of joint penetration and improve fixation of radial styloid and lunate facet stability.
Orofacial manual therapy with oromotor exercises improves cervical movement impairment associated with headache and features of temporomandibular dysfunction: A review article
Authors: Thiyagarajan Alagappan , Elago Jaya Dharshini
Published: May 2023

Temporomandibular joint (TMJ) disorders are a group of conditions that can cause headaches and cervical dysfunction. Cervical dysfunction is manifested by limitations in any part of the kinetic sequence, an important component of which is the temporomandibular joint. The areas of concern in the musculoskeletal system, including the temporomandibular joint and the masseter muscles, are collectively known as temporomandibular disorders (TMJ) and cervical spine disorders. There is also evidence that headaches can cause symptoms that affect the TMJ. Physiotherapy can be used for management of temporomandibular dysfunction and its secondary cervical symptoms. This present article highlights the role of physical therapy in the treatment of TMDs along with cervical spine consideration.
Выявление ситуативной и личностной тревожности у студентов первого курса разных специальностей
Authors: Гладышева О.В. , Хабарова Т.Ю. , Хабарова С.С.
Published: May 2023

В статье рассмотрена проблема тревожности у студентов первого курса. Приводятся результаты диагностики ситуативной и личностной тревожности у студентов, обучающихся по разным специальностям. На основе проведенного исследования были даны рекомендации преподавателям, направленные на предотвращение и снижение степени тревожности у студентов.
Проникновение Аниме в современную российскую культуру (на примере города Комсомольска-на-Амуре)
Authors: Васильченко А.В.
Published: May 2023

Основной целью работы являлось исследование особенностей проникновения Аниме в современную российскую культуру. В процессе исследования отмечено, что азиатская субкультура Аниме обрела огромную популярность в современной России, проявляющаяся в использовании символики и атрибутики Аниме в повседневной жизни российских подростков и молодежи, а также в проведении различных мероприятий, посвященных Аниме: косплеев, ярмарок, выставок, пати, фестивалей, показов фильмов и др. Подобные мероприятия активно проводятся в городе Комсомольске-на-Амуре.
Культурно-интеллектуальная история освоения Северо-Востока России: опыт регионального исследования
Authors: Алексеева С.А.
Published: May 2023

Интеллектуальная история – одна из наиболее интенсивно развивающихся отраслей исторического знания, изучающая интеллектуальное наследие (идеи, теории, тексты) через призму культуры и социокультурного окружения их носителей. В ИГИиПМНС СО РАН (г. Якутск) коллективом исследователей разрабатывается оригинальная региональная модель культурно-интеллектуальной истории освоения Севера, впервые на основе сочетания методологии когнитивной антропологии, транснациональной истории и интеллектуального ландшафта в рамках цивилизационного дискурса воссоздаются культурные и гуманитарные аспекты освоения Севера. Также в данной статье дан краткий обзор истории становления и развития интеллектуальной истории в российском и зарубежном гуманитарном пространстве.