bluuebunny/crossref_metadata_2025 huggingface dataset:
Tehnik Peningkatan Imunitas Jiwa dan Penerapan Protokol Kesehatan dalam Persiapan Kegiatan Pembelajaran Saat New Normal Era
Authors: Cahyono Bagus Dwi , Huda Nurul , Aristawati Evy
Published: August 2021

ABSTRAK Kondisi pandemic Covid-19 merubah dunia, hal yang tidak lazim menjadi lazim. Semua kegiatan dilakukan dari rumah, hal ini memicu seseorang mengalami stress dan menurunkan imun dalam tubuh. Kondisi pandemic memaksa remaja melakukan semua kegiatan di rumah.  Remaja rentan mengalami stress, hal ini bisa menurunkan daya tahan tubuhnya dan lebih rentan sakit. Jika remaja sering mengalami sakit, maka akan mempengaruhi proses pertumbuhan dan perkembangannya. Orang tua memiliki peranan penting dalam menjaga kondisi anaknya. Pandemic Covid-19 mengharuskan pembelajaran dilakukan secara online, tapi di Madin Al Muhajirin pembelajaran dilakukan dengan tatap muka karena sudah masuk zona hijau. Pemberian pengetahuan dan latihan tehnik peningkatan imunitas jiwa serta penerapan protocol kesehatan dalam kegiatan pembelajaran saat new normal era adalah hal yang harus segera dilakukan agar santri memiliki pengetahuan serta terampil menerapkan terapi aktivitas kelompok serta penerapan protocol kesehatan baik dilakukan di rumah maupun di lingkungan madrasah diniyah. Metode yang digunakan dalam pengabdian ini adalah penyuluhan pada 27 santri. Hasil evaluasi sebagian besar santri (80%) memahami dan mengerti tentang dan mampu mempraktekkan cara cuci tangan, menggunakan masker dan melepas masker, serta melakukan kegiatan terapi aktivitas kelompok. Kata Kunci : imunitas jiwa, protokol kesehatan, pembelajaran new normal  ABSTRACT The conditions of the Covid-19 pandemic have changed the world; things that are not uncommon are becoming commonplace. All activities are carried out from home; this triggers a person to experience stress and lowers immunity in the body. Pandemic conditions force teenagers to do all activities at home. Teenagers are prone to anxiety; this can reduce their immune system and are more prone to illness. If adolescents often experience illness, it will affect the process of growth and development. Parents have an essential role in maintaining the condition of their children. The Covid-19 pandemic requires learning to be done online, but at Madin Al Muhajirin, learning is done face-to-face because it has entered the green zone. Giving knowledge and training in mental immunity enhancement techniques and implementing health protocols in learning activities during the new normal era must be done immediately so that students can implement group activity therapy and implement health protocols both at home and in Madrasah Diniyah circles. The method used in this service was counseling 27 students. The results of the evaluation most of the students (80%) understand and understand about and can practice how to wash hands, use masks and remove masks, and carry out group therapy activities. Keywords: mental immunity, health protocol, new normal learning
Mempersiapkan Pilkada Yang Aman Dan Sehat Di Era Pandemic Covid-19
Authors: Nastiti Ayu Dewi
Published: August 2021

ABSTRAK Pemilihan kepala Daerah atau Pilkada adalah wujud demokrasi dan Hak Asasi Manusia (HAM). Pemilihan kepala daerah pada tahun ini sangatlah berbeda dari Pilkada-Pilkda sebelumnya, dikarenakan ini pertama kalinya dilaksanakan Pemilihan Kepala Daerah di tengah – tengah pandemi Covid-19. Berdasarkan keputusan yang sudah ditetapkan oleh pemerintah, tentunya pemerintah harus juga memikirkan terhadap resiko terburuk yang akan terjadi, yaitu kasus covid-19 akan semakin meningkat. Untuk itu perlu adanya strategi yang harus dilaksakan selama pelaksanaan pilkada. Melalui Penyuluhan tentang covid-19 dan cara memutus mata rantai penyebarannya diharapkan pengetahuan masyarakat khususnya bagi petugas pilkada meningkat, mengingat petugas pilkada akan berinteraksi dengan banyak orang saat pelaksanaan pilkada, sehingga pelaksanaan Pilkada bisa berjalan aman dan sehat. Hasil evaluasi sebagian besar peserta (90%) memahami dan mengerti tentang  materi yang disampaikan. Peserta senang dengan penyuluhan ini, hal ini terbukti dengan banyaknya peserta yang aktif dalam diskusi dan mengajukan pertanyaan serta antusias ketika pelaksanaan diskusi. Kata Kunci : Pilkada, Petugas Pilkda, Covid-19  ABSTRACT The democratic party for the Regional Head Election or better known as the Pilkada is the manifestation of democracy and human rights (HAM). This year's regional head elections are very different from the previous Pilkada-Pilkda, because this is the first time a Regional Head Election has been held in the midst of the Covid-19 pandemic. Based on the decision that has been set by the government, of course, the government must also think about the worst risk that will occur, namely the covid-19 case will increase. For this reason, it is necessary to have a strategy that must be implemented during the implementation of the elections. Through counseling about covid-19 and how to break the chain of distribution, it is hoped that public knowledge, especially for election officials, will increase, considering that pilkada officers will interact with many people during the election, so that the implementation of the Pilkada can run safely and healthily. The results of the evaluation, most of the participants (90%) understood and understood the material presented. The participants were happy with this counseling, this was proven by the many participants who were active in the discussion and asked questions, and were enthusiastic during the discussion. Keywords: Pilkada, Pilkda Officer, Covid-19
Pendekatan Edukatif Tentang Breast Care Pada Ibu Hamil Dan Nifas Di Klinik BPM Mariana Binjai
Authors: Sinurat Lasma Rina Efrina , Sipayung Rosetty Rita , Marbun Agnes Silvina
Published: August 2021

ABSTRAK Perawatan payudara sangat penting dilakukan selama hamil sampai masa menyusui. Hal ini karena payudara merupakan satu-satunya penghasil ASI yang merupakan makanan pokok bayi baru lahir sehingga harus dilakukan sedini mungkin. Breast care bertujuan untuk memelihara kebersihan payudara, memperbanyak atau memperlancar pengeluaran ASI.Tujuan pengabdian masyarakat ini adalah untukmempersiapkan ibu hamil dan nifas agar dalam kondisi baik saat menyusui bayinya dan agar mampu mendemontrasikan perawatan payudara dengan benar secara mandiri di rumah. Adapun metode pengabdian masyarakat ini dengan pendekatan edukatif tentang perawatan payudara pada ibu hamil dan nifas di klinik BPM Mariana Binjai dalam bentuk ceramah dan tanya jawab serta melakukan demonstrasi perawatan payudara. Hasil dari pengabdian masyarakat ini adalah menjaga kebersihan payudara terutama kebersihan puting susu, melenturkan dan menguatkan puting susu sehingga memudahkan bayi untuk menyusu, merangsang kelenjar-kelenjar air susu sehingga produksi ASI banyak dan lancar, dapat mendeteksi kelainan-kelainan payudara secara dini dan melakukan upaya untuk mengatasinya dan mempersiapkan mental (psikis) ibu untuk menyusui. Diharapkan setelah dilakukan pendekatan edukatif ini ibu hamil dan nifas pengetahuannya semakin meningkat dan mampu mempersiapkan pemberian ASI eksklusif kepada bayinya. Kata Kunci : edukasi, breast care, ibu hamil dan nifas  ABSTRACT Breast care is very important during pregnancy until breastfeeding. This is because the breast is the only producer of breast milk which is the staple food for newborns, so it must be done as early as possible. Breast care aims to maintain breast hygiene, increase or facilitate breastfeeding. The aim of this community service is to prepare pregnant and childbirth mothers to be in good condition when breastfeeding their babies and to be able to demonstrate proper breast care independently at home. The community service method uses an educational approach on breast care for pregnant and postpartum mothers at the BPM Mariana Binjai clinic in the form of lectures and questions and answers as well as conducting breast care demonstrations. The result of this community service is maintaining breast cleanliness, especially nipple hygiene, flexing and strengthening the nipple so that it makes it easier for babies to breastfeed, stimulating the milk glands so that milk production is large and smooth, can detect breast abnormalities early and make efforts to overcome it and prepare the mother mentally (psychologically) to breastfeed. It is hoped that after this educational approach, pregnant and post-partum women will have increased knowledge and be able to prepare exclusive breastfeeding for their babies. Keywords : education, breast care, pregnant women and postpartum
Pendampingan Kader Kesehatan Dalam Deteksi Dini Penyakit Degue Haemoraghic Fever (DBD) Di Dusun 1 Desa Sukabanjar Kecamatan Gedong Tataan Kabupaten Pesawaran Bandar Lampung
Authors: Chloranyta Shanty
Published: August 2021

ABSTRAK Deteksi Dini penyakit Dengue Haemoragic Fever di Dusun 1 Desa Sukabanjar Kecamatan Gedong Tataan Kabupaten Pesawaran Bandar Lampung belum dilakukan dengan baik di Wilayah Kerja Puskesmas Bernung. Hambatan yang ditemukan yakni pengetahuan kader kesehatan tidak adekuat, belum tersedianya informasi yang adekuat tentang deteksi dini penyakit dengue haemoragic fever (DBD) pada kader kesehatan. Pelibatan kader kesehatan dalam edukasi mengenai deteksi dini penyakit DBD menentukan keberhasilan dalam penanganan awal DBD. Tujuan kegiatan pengabdian masyarakat yang dilakukan dalam pendampingan kader kesehatan untuk meningkatkan pengetahuan dan peran kader kesehatan dalam masyarakat dalam deteksi dini DBD. Kegiatan dilakukan di Kantor Kelurahan Dusun 1 Desa Sukabanjar Kota Bandar Lampung pada bulan Desember 2018. Metode yang dilakukan yakni ceramah, diskusi, praktek cara  melakukan rumpled test. Hasil dari kegiatan pengabdian masyarakat ini didapatkan peningkatan pengetahuan kader kesehatan tentang deteksi dini DBD. Kegiatan pengabdian masyarakat yang dilakukan adalah bentuk upaya dalam deteksi dini DBD dengan melibatkan kader kesehatan. Kata Kunci : Deteksi Dini, Kader Kesehatan, Rumpled Test  ABSTRACT Early detection of dengue hemorrhagic fever in Dusun 1, Sukabanjar Village, Gedong Tataan Subdistrict, Pesawaran Regency, Bandar Lampung, has not been carried out properly in the Work Area of the Bernung Health Center. The obstacles found were inadequate knowledge of health cadres, inadequate information on early detection of dengue hemorrhagic fever (DHF) among health cadres. The involvement of health cadres in education regarding early detection of dengue disease determines the success in the initial handling of dengue. The purpose of community service activities carried out in mentoring health cadres is to increase knowledge and the role of health cadres in the community in the early detection of dengue fever. The activity was carried out at the Subdistrict Office of Dusun 1, Sukabanjar Village, Bandar Lampung City in December 2018. The methods used were lectures, discussions, practice on how to do a rumpled test. The results of this community service activity were found to increase the knowledge of health cadres about the early detection of dengue. Community service activities carried out are a form of effort in early detection of dengue by involving health cadres. Keyword: early detection, Health cadres, rumpled test
Edukasi Kesehatan Vaksin Dan Penerapan Protokol Kesehatan Covid-19 Pada Masyarakat Dusun Cenrana Desa Carawali Kabupaten Sidrap
Authors: Asnuddin Asnuddin , Sakinah Sri , S Meriem Meisyaroh , Nurdin Sulkifli , Hasrul Hasrul , Murtini Murtini , Suparta Suparta , Hasnah Hasnah
Published: August 2021

ABSTRAK Salah satu jenis penyakit baru dan belum pernah terdeteksi maupun terindetifikasi dari manusia, yang kemudian diberikan nama Coronavirus Disease 2019 (COVID19). Prinsip pencegahan dan strategi pengendalian secara umum saat ini masih belum ada vaksin untuk mencegah infeksi covid-19. Cara terbaik untuk mencegah infeksi adalah dengan menghindari terpapar virus penyebab. Tujuan setelah penyuluhan, diharapkan masyarakat dapat mengetahui manfaat dari vaksin dan selalu menerapkan protokol kesehatan dapat mencegah virus covid 19. Adapun kegiatan yang dilakukan berupa penyuluhan kesehatan tentang vaksin dan penerapan protokol kesehatan di era New Normal. Terdapat peningkatan pengetahuan pada masyarakat dalam pencegahan penyakit covid-19 pada masyarakat Dusun Cenrana Desa Carawali. Dengan demikian, pemberian penyuluhan pada masyarakat tentang pencegahan penyakit virus Covid-19 berjalan dengan baik dan mendapatkan respon yang positif dari masyarakat dan pihak pemerintahan. Kata Kunci : Edukasi, Vaksin, Protokol Kesehatan, dan Covid-19  ABSTRACT One of the new types of disease and has never been detected or identified from humans, which was later given the name Coronavirus Disease 2019 (COVID19). There is currently no vaccine to prevent infection with COVID-19. The best way to prevent infection is to avoid being exposed to the virus that causes it. The goal after the counseling is is hoped that the public can know the benefits of vaccines and always apply health protocols to prevent the covid 19 virus. The activities carried out are in the form of health education about vaccines and the application of health protocols in the New Normal era. There is an increase in knowledge in the community in preventing covid-19 disease in the Cenrana Hamlet community, Carawali Village. Thus, the provision of counseling to the public about the prevention of the Covid-19 virus disease went well and received a positive response from the community and the government. Keywords: Education, Vaccines, Health Protocols, and Covid-19
Satranç A Milli Oyuncularının Toplam ve Bölgesel Vücut Kompozisyonu Bileşenleri
Authors: Aktitiz Selin , Bulut Süleyman , Atakan Muhammed Mustafa , Güzel Yasemin , Atabey Ceren Işıl , Koşar Şükran Nazan , Turnagöl Hüseyin Hüsrev
Published: August 2021

Amaç: Satranç oyununun karakteri gereği oyuncular gün içerisinde uzun süre (3-4 saat/gün) oturarak alıştırma yaptıklarından fiziksel aktivitelere katılımları sınırlanmaktadır. Bu durum satranç oyuncuları için sedanter yaşam tarzını arttırarak fazla kilo/obezite ve ilişkili kronik hastalıklar riskini artırabilir. Bu çalışmanın amacı, elit düzeydeki satranç oyuncularının toplam ve bölgesel vücut kompozisyonu bileşenlerinin beden kütle indeksi (BKİ), yaş ve cinsiyete göre eşleştirilmiş kontrollerle karşılaştırılmasıdır.

Bireyler ve Yöntem: Çalışmaya 12 A-Milli satranç oyuncusu (yaş: 24.9±5.9 yıl; BKİ: 23.5±2.8 kg/m2) ve 12 kontrol katılımcı (yaş: 24.6±1.6 yıl; BKİ:23.5±3.3 kg/m2) alınmıştır. Vücut kompozisyonu, dual enerji x-ray absorbsiyometri cihazı ile ölçülmüştür. Satranç ve kontrol gruplarının karşılaştırılmasında bağımsız gruplarda t-test analizi kullanılmıştır.

Bulgular: Kontrol grubuna kıyasla satranç oyuncularının toplam yağ kütlesi, viseral yağ kütlesi ve yağ oranı daha yüksek; yağsız yumuşak doku kütlesi ve kemik kütlesi ise daha düşük bulunmuş olmakla beraber bu farklılıklar istatistiksel olarak önemli değildir (p>0.05). Kadın satranç oyuncularının toplam yağ oranı kontrol grubununkine benzer (p>0.05), viseral yağ kütlesi ise daha düşüktür (p=0.015). Erkek satranç oyuncuları, kontrol grubuna kıyasla daha düşük yağsız yumuşak doku ve daha yüksek yağ oranına sahip olmakla beraber istatistiksel olarak anlamlı fark bulunmamıştır (p>0.05). Her iki cinsiyette de satranç oyuncularının bölgesel yağ oranları (kol, gövde, bacak, android, jinoid) kontrol grubundan daha yüksek bulunmakla beraber bu bulgu istatistiksel olarak önemli değildir (p>0.05). Vücut yağ ve kas düzeyi göstergeleri değerlendirildiğinde, erkek satranç oyuncuları kontrol grubuna kıyasla daha yüksek yağ kütlesi indeksi, daha düşük toplam ve apendiküler yağsız yumuşak doku kütlesi indekslerine sahip olmakla beraber bu farklılıklar istatistiksel olarak anlamlı bulunmamıştır (p>0.05). Kadın satranç sporcularında da yağ kütlesi indeksi ve apendiküler yağsız yumuşak doku kütlesi indeksi değerleri kontrol grubuyla benzer (p>0.05) iken yağsız yumuşak doku kütlesi indeksi daha düşük bulunmuştur (p=0.022).

Sonuç: Bu çalışmada değerlendirilen A milli satranç oyuncularının toplam ve bölgesel vücut kompozisyonu bileşenleri BKİ, yaş ve cinsiyet yönünden eşdeğer kontrollerle benzerdir.
Community Empowerment for Self-sufficiency in Herbal Plants to Face The Covid-19 Pandemic
Authors: Herdiani Novera , Wijaya Satriya
Published: August 2021

Indonesia is famous for its rich herbs. Typically, these herbs are used as flavoured vegetables, medicinal plants, dried fruit and medicinal plants that are packed in the form of herbs. Some herbs are very good for curing and healing. During the COVID-19 pandemic, the need for spices is getting higher, but prices are also high. This has an impact on the cost of community needs. Community service aims to use herbs to improve the immune system in the face of COVID-19. Besides, for the use of the house yard by planting herbs as traditional medicinal plants with community empowerment. The methods used were counselling about spice plants, dividing spice plant seeds, and practising directly growing spices. The community service subjects were 41 residents Taman District on Provinsi of Sidoarjo, especially in a community group on 25 in Citizens Association of 10 Bohar Village, Taman Sidoarjo District. According to the results of the evaluation of the participant's knowledge assessment, according to the results of the pre-test and post-test evaluations, it was found that most of the participants experienced an increase in knowledge of spices (56.1%). Most residents (85%) prefer the direct practice method of planting spices because it is easier to understand right away. The conclusion indicated the effectiveness of the introduction and use of spices in increasing knowledge and direct cultivation practice. The next community service activity is to provide assistance and train residents in environmental cadre formation activities and the formation of TOGA plants. The output of this community service activity is a report that has been submitted in a journal and an increase in public understanding and awareness by planting spices.
Pelatihan Dan Pendampingan Sistem Informasi Manajemen Di Era New Normal
Authors: Sariani Ni Luh Putu , Satya Utami Ni Made Satya Utami
Published: August 2021

Bali has a charm nature, unique culture that captivated the hearts of foreign tourists and domestic to visit. Since the pandemic covid-19 struck the world, economic growth in Bali the year 2020 has decreased, because one of the economic incomes of the business sector tourism. Efforts The government Bali restore the economy, turn on the micro, small and medium Enterprises (SMES). Peken Facebook is the SMES take the opportunities businesses trading through online networks and social media that continues to innovate using digital technology in the pandemic covid-19. Based on observation and interview found a weakness, the absence of application of Management Information System (SIM) the better. The purpose for apply SIM in the running of the operational business Peken Facebook so the quality of services increased as well as customer satisfaction achieved. Methods the activities of socialization, provides training and the practice of direct application of SIM and mentoring. The results of the activity show the high enthusiasm of the participants, Peken Facebook apply SIM in the running of their business operations to support service activities to meet the needs of the consumer. Conclusion, the service is done to increase the quality of human resources and partnerships, understand the concept of SIM as well as can give the satisfaction of consumers. Advice, Peken Facebook expected can apply the SIM properly, perform the evaluation in accordance with the development of market conditions so that it can create, innovate, following the development of better technology, particularly in terms of the provision of excellent service to the consumer.
Systematic Review: Comparison of triple drug therapy versus double drug therapy for Lymphatic Filariasis
Authors: Yana I Gusti Agung Ari Kusuma
Published: August 2021

Background: Lymphatic filariasis is a parasitic infection caused by nematodes such as filaria Wuchereria bancrofti, Brugia malayi, and Brugia timori. These parasites can be transmitted through mosquito bites such as several species of mosquitoes, particularly Anopheles, Aedes, Culex, and Mansonia with geographical variations in the dominant vector identity. The main strategy used consists of community-wide mass drug administration (MDA) for the entire population at risk to stop disease transmission and prevent infectious morbidity. WHO recommends the use of annual medication in combination with the triple drug ivermectin therapy.
Objective: To compare DEC and albendazole (IDA) versus the two drugs albendazole and diethycarbamazine or albendazole and ivermectin therapy.
Methods: The literature search was carried out independently by the researcher using the Sciencedirect, Pubmed, and Cochrane online databases without limiting the type of study or the year of publication. The keywords used in this study were combined with the Boolean operator, namely "AND" namely ((((Lymphatic filariasis) AND (albendazole)) AND (diethylcarbamazine)) AND (ivermectin)) AND (compare).
Results: Where triple drug therapy was significantly better in reducing and clearing microfilariae and worm nests in patients with lymphatic filariasis compared to two drug therapy alone. However, side effects occur more frequently in the combination of three therapies. The average side effects were low, such as headaches, joint pain, fatigue, and nausea.
Conclusion: although it has relatively low side effects that occur in three drug combinations rather than two drug combination therapy, triple therapy combination therapy is more effective than two drug therapy in treating lymphatic filariasis disease.
The Effect Of Giving Honey on The Process of Wound Healing in Burned Patients
Authors: Pramesty Intan
Published: August 2021

Backgroud: Burns are one of the most dangerous injuries and the main cause of disability to death. Burns can be interpreted as one of the serious problems in society and are recorded to cause around 265,000 deaths each year. Honey can maintain the wound condition to keep it moist and in high viscosity to prevent infection.
Method: This study was conducted to determine the effect of honey on the wound healing process in burn patients. This study uses a literature review method. The population in this study is a journal with a background in the health sector with 10 international journals on burns with the qualifications of 9 SCIMAGO indexed journals and 1 SINTA indexed journal published from 2015 to 2020.
Results: Burns that treated in the form of pure honey can generate good results and heal in an average of 20 days. The healing process will be better, if the wound given a mixture of other ingredients which also have a low acidity such as garlic, chitosan and beeswax and olive oil. Honey has antimicrobial properties and a low pH level. The microbe most sensitive to honey is Staphylococcus aureus.
Conclusion: The conclusion from this study, honey can be used as an alternative treatment for burns.
Organophosphorus pesticide residues detected in eggplant and tomato samples collected from different regions of Bangladesh
Authors: Ahmed Md Sultan , Begum Afroza , Hossain Prodhan Mohammad Dalower , Afroze Marina , Sarker Debasish
Published: August 2021

The study was conducted to detect and quantify the residue of seven commonly used organophosphorus pesticides (acephate, chlorpyrifos, quinalphos, diazinon, malathion, dimethoate and fenitrothion) in eggplant and tomato samples collected from local market of commercially grown four different regions viz. Bogura, Narsingdi, Jeshore and Cumilla for the comparison between the detected residue level with maximum residue limit (MRL) set by European Union. A total of 80 analyzed samples of eggplant and tomato, 21.25% of the total number of samples contaminated with acephate, chlorpyrifos, fenitrothion and diazinon residues which were above the EU-MRLs. Out of 40 analyzed samples of eggplant, 11 samples were contaminated with acephate, diazinon fenitrothion and chlorpyrifos residues. All of the contaminated samples (27.5% of the total number of samples) had chlorpyrifos (0.02-0.046), acephate (0.017-0-0.39), diazinon (0.11-0.47) and fenitrothion (0.20) residues which were above the EU-MRLs. The eggplant samples collected from Jeshore and Narsingdi received more pesticides than Cumilla and Bogura regions. In case of 40 analyzed samples of tomato, 6 samples (15% of the total number of samples) had chlorpyrifos (0.27-0.43), diazinon (0.25) and fenitrothion (0.10) residues which were above EU-MRLs. Malathion, quinalphos and dimethoate residues were not found in any of the tested samples which might be applied at recommended doses.
Asian Australas. J. Food Saf. Secur. 2021, 5 (1), 27-31
Effects of colistin sulfate on hematological parameters in broiler
Authors: Hasan Md Nazmul , Islam Md Shafiqul , Hasan Md Rakibul , Islam Kazi Rafiqul
Published: August 2021

Hematological indication is an important finding for pathophysiological analysis of biological science. This study was designed with the aim to investigate the effects of residual antibiotics on hematological parameters of broiler following discriminate and indiscriminate use. The day old broiler chicks were collected and reared up to 31 days. The treatment was started from the day 16th until sacrifice. The chicks were randomly divided into three groups namely control group (Group A), discriminate antibiotic group (Group B) and indiscriminate antibiotic group (Group C) on the 14th day. The discriminate group was treated with antibiotic, colistin sulfate maintaining the withdrawal period of one week. In case of indiscriminate group the withdrawal period was not maintained and antibiotic treatment was continued till the day of sacrifice. The Hb (%) of control, discriminate and indiscriminate groups were 8.34±0.15, 6.89±0.27, and 7.14±0.23 respectively. The differences among means were statistically significant (P<0.05). The Packed Cell Volume (PCV) of control, discriminate, and indiscriminate groups were 23.51±0.76, 21.17±0.94, and 22.83±1.19 respectively. The differences among means were statistically significant. The multiple pair wise comparison of means of blood parameters revealed that there was no significant difference among discriminate and indiscriminate groups. From the above findings, this research could be considered a need based research in Bangladesh to ascertain the influential effect of antibiotic on hematological parameters in broiler.
Asian J. Med. Biol. Res. 2021, 7 (2), 113-117
Growth performance, hematological parameters and lipid profile of mice treated with black seed oil and vitamin-E
Authors: Mustari Afrina , Sujan Khaled Mahmud , Moni Debasree Sarker , Alam Mahabub , Miah Mohammad Alam , Islam Md Kamrul
Published: August 2021

Nigella sativa (Black seed) has been recognized as one of the most popular herbs in many parts of the world for centuries and used as folk medicine to cure different kinds of diseases. Vitamin E is well known for its antioxidative and anti-inflammatory properties, and has been studied in the prevention of cardiovascular disease (CVD). The present study was performed to determine the effect of black seed oil and Vit-E on growth performance and blood biochemistry in mice. A total of 40 mice weight between 25-27 gm were used for conducting the research. At first, the mice were randomly divided into 4 groups consisting 10 mice in each group. Group A served as the control group whereas Group B was administered black seed oil @ 0.5 ml/kg/day, Groups C was taken vitamin E @ 200 mg/kg/day and Group D was received both black seed oil @ 0.5 ml/kg/day + vitamin E @ 200 mg/kg/day respectively for 42 days. Result showed that, body weight of B, C and D group revealed a significant decrease than the control group (p<0.05). Hemoglobin concentration (Hb) and Total Erythrocyte Count (TEC) showed a significant change in B, C and D group than the control group (p<0.05). On the other hand, Total Leukocyte Count (TLC) and Packed Cell Volume (PCV) were insignificant. The results of biochemical test explored that serum cholesterol and triglyceride value decreased significantly whereas HDL increased significantly in black seed oil, Vit-E treated groups than the control group (p<0.05). But the LDL showed no change after treatment. It could be concluded that the black seed oil and Vit-E can be used in the therapeutic strategy of obesity, anemia and coronary diseases.
Asian J. Med. Biol. Res. 2021, 7 (2), 132-137
Prevalence of urinary tract infections, associated risk factors, and antibiotic resistance pattern of uropathogens in young women at Noakhali, Bangladesh
Authors: Hossain Imam , Bhowmik Sutapa , Uddin Mohammad Sharif , Devnath Popy , Akter Asma , Eti Lutfun Nahar , Hussen Shakhawat , Rahman Nayem Mohammad Maksudur , Rahman Shahidur , Sayem SM , Islam Md Towhidul
Published: August 2021

Urinary tract infection (UTI) remains one of the most common infections among young females diagnosed in developing countries. The emergence of antibiotic resistance among uropathogens is a global problem. This study aimed to determine the prevalence and resistance of antibiotics to uropathogens, and to understand the relationship of uropathogens to multiple clinical, social and demographic factors of young female students in a university in Bangladesh. Four hundred freshly voided midstream urine samples collected from young female students and several clinical and socio-demographic variables along with UTI symptomatic queries were determined. Bacterial isolation was carried out by using standard and specific microbiological techniques and antimicrobial susceptibility pattern was determined by Kirby Bauer Disc diffusion method. Among the tested specimens, 106 (26.5%) has significant bacterial growth, 60 (57%) were symptomatic, and 46 (43%) were asymptomatic. The highest uropathogen was recorded within the age group of 24-25 years (51%). There was a significant association (p < 0.05) of uropathogen with anatomical abnormality of urinary tract, water sources for food preparation and bathing, and the number of person sharing the same toilet. Most predominantly isolated bacteria were E. coli (32.08%) followed by Staphylococcus saprophyticus (24.53%), Streptococcus spp. (16.04%), Klebsiella spp. (14.15%), Aceinetobacter spp. (4.72%), Citrobacter spp. (2.83%), Enterobacter spp. (2.83%), and Pseudomonas spp. (2.83%). In the effectiveness of each treated antibiotic, urinary pathogens were highly resistant towards nalidixic acid (80.19%), ampicillin (75.73%), cephalexin (70%) and azithromycin (68.48) while against imipenem (7.94%) and amikacin (18.87%) least resistancy were found. A good understanding of the etiology of uropathogens will assist the general practitioner to identify the correct therapeutic strategy for the proper management of UTIs.
Asian J. Med. Biol. Res. 2021, 7 (2), 202-213
Prospects for Constitutional and Human Rights Transformation through Constitutional Adjudication in Zimbabwe after 2013
Authors: Tembo Simbarashe , Singh Annette
Published: August 2021

The article is based on the notion that real socio-economic and political transformation did not follow the adoption of the 2013 Zimbabwean Constitution. Relying on theories of constitutionalism, transformational constitutionalism and transformative adjudication as contemplated by Karl Klare, the question of whether it is possible for the transformation agenda to be accomplished in the absence of political will, and the extent to which the courts can be used as a means of attaining this, is addressed. The article uses a socio-legal research method by drawing arguments from legal and policy-related literature. The jurisprudence of the Zimbabwean Constitutional Court is compared with other jurisdictions such as Kenya and South Africa that adopted interpretative and adjudication methods that have changed the lives of the people, especially with regard to socio-economic and civil and political rights. It is observed that while commendable progress has been made by the Zimbabwean courts, the jurisprudence is still fraught with inconsistencies and lacking in transformative legal culture.
La tasa de Mortalidad General del Ecuador del INEC subestima erróneamente al Cáncer
Authors: Campoverde Merchán Felipe , Campoverde Arévalo Nicolás , García Matamoros EDITOR: Katherine
Published: August 2021

Introducción: La aplicación del sistema de clasificación 6-61 para obtener la tasa mortalidad dentro de las estadísticas del Instituto Nacional de Estadísticas y Censos (INEC) tiene un sesgo de contabilidad en las diferentes patologías: en casos particulares incluye categorías y subcategorías de las enfermedades oncológicas y en otros casos excluye a las categorías y solo se contabiliza la subcategoría, por este motivo, se planteó el presente estudio de bases de datos (BD) para obtener la verdadera tasa de mortalidad incluyendo las categorías excluidas.

Metodología: El presente estudio es una revisión de BD de mortalidad en el Ecuador. El periodo analizado enero 1990 – diciembre 2016, usando las BD de mortalidad en el Ecuador disponible en el sitio web del INEC. Se sumaron las categorías a las enfermedades oncológicas excluidas, según el CIE-10 que le INEC no consideró como enfermedad oncológica.

Resultados: La mortalidad en el Ecuador de las enfermedades oncológicas, presentada como porcentaje acumulado de 10.25% en el año 1990 y tiene un incremento progresivo hasta un 14.8% en el año 2016, lo que constituye la primera causa de muerte en todos los años del estudio.

Conclusiones: El cáncer es la primera causa de muerte, no sólo debido al aporte de determinadas provincias, sino un fenómeno más amplio, posiblemente en todo el territorio del Ecuador, lo cual se asocia posiblemente a un cambio epidemiológico que corresponde a la modernidad.
Sosialisasi Gerakan Masyarakat Sehat dan Pencegahan Stunting di Pondok Pesantren Husnayain
Authors: Nasrul Nasrul , Hafid Fahmi , Lisnawati  , Amsal  , Masudin  , Sri Musriniawati Hasan  , Wijianto
Published: August 2021

Keberhasilan gerakan masyarakat sehat tidak terlepas dari kerjasama lintas sektor. Salah satunya dengan Lembaga Pendidikan keagamaan seperti pesantren. Pesantren dapat menjadi fondasi yang kuat bagi penggalakan gerakan masyarakat hidup sehat terutama bagi santri dan pengurusnya. Tujuan pengabdian masyarakat ini adalah terlaksananya kegiatan Sosialisasi Pesantren dan Santri Sehat Pesantren Husnayain Kota Palu. Metode pelaksanaan dengan Sosialisasi Pesantren dan Santri Sehat kepada 20 santri dan santriwati serta pengurus pesantren. Pelaksanaan pada tanggal 8-10 Februari 2021 di Pondok Pesantren Husnayain Kelurahan Silae Kecamatan Ulujadi Kota Palu Sulawesi Tengah. Hasil yang diperoleh dari kegiatan sosialisasi ini adalah terjalinnya kerjasama antara Poltekkes Kemenkes Palu dengan Pesantren Husnayain dalam rangka pembentukan Pos Kesehatan Pesantren (Poskestren) dan pembinaan pesantren dan santri sehat di Kota Palu.
Biochemical and Structural Characterisation of a Novel D-Lyxose Isomerase From the Hyperthermophilic Archaeon Thermofilum sp.
Authors: De Rose Simone Antonio , Kuprat Tom , Isupov Michail N. , Reinhardt Andreas , Schönheit Peter , Littlechild Jennifer A.
Published: August 2021

A novel D-lyxose isomerase has been identified within the genome of a hyperthermophilic archaeon belonging to the Thermofilum species. The enzyme has been cloned and over-expressed in Escherichia coli and biochemically characterised. This enzyme differs from other enzymes of this class in that it is highly specific for the substrate D-lyxose, showing less than 2% activity towards mannose and other substrates reported for lyxose isomerases. This is the most thermoactive and thermostable lyxose isomerase reported to date, showing activity above 95°C and retaining 60% of its activity after 60 min incubation at 80°C. This lyxose isomerase is stable in the presence of 50% (v/v) of solvents ethanol, methanol, acetonitrile and DMSO. The crystal structure of the enzyme has been resolved to 1.4–1.7 A. resolution in the ligand-free form and in complexes with both of the slowly reacting sugar substrates mannose and fructose. This thermophilic lyxose isomerase is stabilised by a disulfide bond between the two monomers of the dimeric enzyme and increased hydrophobicity at the dimer interface. These overall properties of high substrate specificity, thermostability and solvent tolerance make this lyxose isomerase enzyme a good candidate for potential industrial applications.
An Integrated Smart Sensor Dressing for Real-Time Wound Microenvironment Monitoring and Promoting Angiogenesis and Wound Healing
Authors: Zhang Yuheng , Li Tian , Zhao Congying , Li Jinqing , Huang Rong , Zhang Qianru , Li Yongqian , Li Xueyong
Published: August 2021

Prolonged chronic wound healing not only places great stress on patients but also increase the health care burden. Fortunately, the emergence of tissue-engineered dressings has provided a potential solution for these patients. Recently, the relationship between the wound microenvironment and wound healing has been gradually clarified. Therefore, the state of wounds can be roughly ascertained by monitoring the microenvironment in real time. Here, we designed a three-layer integrated smart dressing, including a biomimetic nanofibre membrane, microenvironment sensor and β-cyclodextrin-containing gelatine methacryloyl (GelMA + β-cd) UV-crosslinked hydrogel. The hydrogel helped increase the expression of vascular endothelial growth factor (VEGF) through hypoxia-inducible factor-1α (HIF-1α) to promote neovascularization and wound healing. The microenvironment sensor, combined with the biological dressings, exhibited satisfactory measurement accuracy, stability, durability and biocompatibility. A BLE4.0 antenna was used to receive, display and upload wound microenvironment data in real time. Such integrated smart dressings can not only achieve biological functions but also monitor changes in the wound microenvironment in real time. These dressings can overcome the challenge of not knowing the state of the wound during the healing process and provide support for clinical work.
N6-Methyladenosine-Regulated mRNAs: Potential Prognostic Biomarkers for Patients With Lung Adenocarcinoma
Authors: Sun Junjun , Ping Yili , Huang Jingjuan , Zeng Bingjie , Ji Ping , Li Dong
Published: August 2021

Aberrant regulation of m6A mRNA modification can lead to changes in gene expression, thus contributing to tumorigenesis in several types of solid tumors. In this study, by integrating analyses of m6A methylation and mRNA expression, we identified 84 m6A-regulated mRNAs in lung adenocarcinoma (LUAD). Although the m6A methylation levels of total RNA in LUAD patient tumor tissue were reduced, the majority (75.2%) of m6A-regulated mRNAs were hypermethylated. The m6A-hypermethylated mRNAs were mainly enriched in terms related to transcription factor activity. We established a 10-m6A-regulated-mRNA signature score system through least absolute shrinkage and selection operator Cox regression analysis, with its predictive value validated by Kaplan–Meier curve and time-dependent receiver operating characteristic curves. RFXAP and KHDRBS2 from the signature also exhibited an independent prognostic value. The co-expression and interaction network analyses demonstrated the strong correlation between m6A regulators and the genes in the signature, further supporting the results of the m6A methylation modification patterns. These findings highlight the potential utility of integrating multi-omics data (m6A methylation level and mRNA expression) to accurately obtain potential prognostic biomarkers, which may provide important insights into developing novel and effective therapies for LUAD.
Amido-Functionalized Magnetic Metal−Organic Frameworks Adsorbent for the Removal of Bisphenol A and Tetracycline
Authors: Zhang Guangpu , Wo Rong , Sun Zhe , Xiao Lei , Liu Guigao , Hao Gazi , Guo Hu , Jiang Wei
Published: August 2021

In this paper, amido-functionalized MOFs with core/shell magnetic particles (Fe3O4@MIL-53(Al)-NH2) was prepared by the solvothermal method and characterized by X-ray diffraction (XRD), transmission electron microscopy (TEM), scanning electron microscopy (SEM), Fourier transform infrared (FT-IR), Vibrating Sample Magnetometer (VSM) and UV/VIS spectrophotometer. The influence of different factors on the adsorption effect of the pollutant, including adsorbent amounts, adsorption time, ionic strength and pH, were explored. It was found that the amine-decorated Fe3O4@MIL-53(Al)-NH2 were efficient for removal of contaminant, with the adsorption capacity for bisphenol A (234.1 mg/g) and tetracycline (84.8 mg/g) under the optimized conditions. The adsorption kinetics and the equilibrium adsorption data indicated that the adsorption process of BPA and TC was more compatible with the pseudo-second-order kinetic model and the Langmuir model, respectively. The thermodynamic values show the adsorption of the mentioned contaminant was spontaneous and endothermic. Moreover, the Fe3O4@MIL-53(Al)-NH2 adsorbent had good regeneration and reusability capacity after five cyclic utilization. All these results show Fe3O4@MIL-53(Al)-NH2 adsorbent could be a potential candidate for future water purification.
Design and Synthesis of AIE-Based Small-Molecule and Nanofibrous Film for Fluorescent Sensing Application
Authors: Ma Chunping , Li Zhiyi , Zhang Chenglin , Xie Gaoyi , Wu Yancheng , Zhang Yangfan , Mo Jinpeng , Liu Xi , Wang Ke , Xie Dong , Li Yang
Published: August 2021

Fluorescent sensors that respond to environmental conditions (temperature, pressure, and pH) have attracted widespread attention in recent years. Generally, traditional solid-state fluorescent materials tend to suffer from aggregation-induced quenching (ACQ) and difficulty of film forming, limiting their extensive applications. Therefore, researchers are focusing more and more attention on fluorescent sensors with aggregation-induced emission (AIE) effects. Herein, the article reports an AIE molecule (TPEBZMZ) containing tetraphenylethylene (TPE) and benzimidazole fragments. The fluorescence properties of TPEBZMZ in solution and aggregation states have been investigated, and the luminescence performance and aggregation structures of solid-state TPEBZMZ after force and acid treatments have been explored. The results show obvious AIE and fluorescent sensing properties of TPEBZMZ, presenting force- and acid-induced discolorations. Moreover, the TPEBZMZ-based fluorescent nanofibrous film is fabricated by electrospinning the solution of TPEBZMZ blended with polylactic acid (PLA), which shows a good nanofiber film structure and exhibits reversible acid-induced discoloration property, even with only 0.5 wt% TPEBZMZ. This work provides a simple strategy to achieve stimulus-responsive fluorescent film.
Warning Decision-Making for Landslide Dam Breaching Flood Using Influence Diagrams
Authors: Zhu Yan , Peng Ming , Zhang Peng , Zhang Limin
Published: August 2021

Warning and evacuation are among the most effective ways for saving human lives and properties from landslide dam hazards. A new warning decision model for landslide dam break is developed using Influence Diagrams to minimize the total losses. An Influence Diagram is a simple visual representation of a decision problem. It analyzes the qualitative (causal) relationships between the variables via a logic diagram and determines the quantitative relationships via conditional probability and Bayes’ theorem. The model is applied for the warning decision-making of the 2008 Tangjiashan landslide dam. The new model unifies the dam failure probability, evacuation, life loss, and flood damage in an Influence Diagram. Besides, a warning criterion is proposed for efficient decision-making. The model is more advanced than the decision tree since the inter-relationships of influence factors are qualitatively analyzed with causality connections and quantitatively analyzed with conditional probabilities. It is more efficient than a dynamic decision-making model (DYDEM) as it can directly calculate the three types of flood loss (i.e., evacuation cost, flood damage, and monetized life loss) and the expected total loss. Moreover, the probabilities of the influence factors leading to known results can be obtained through inversion analysis based on Bayesian theory. The new warning decision model offers an efficient way to save lives from landslide dam breaking and avoid unnecessary expenses from premature warning and evacuation.
Seismic Damage and Analysis of the Xiker Earth Dam During the 2020 Jiashi Earthquake, Northwestern China
Authors: Yao Yuan , Tang Lihua , Li Wenqian , He Jingang , Jia Hailiang
Published: August 2021

The 2020 Jiashi Mw 6.0 earthquake occurred at the Kepingtage fold-and-thrust belt in the South Tianshan front, Northwestern China. The ground shaking caused extensive co-seismic deformation of the Xiker dam in the meizoseismal area. We obtained strata distribution characteristics of the dam foundation through drilling. Using laboratory andin situtests, the particle size distribution, standard penetration, and shear wave velocity of each layer were obtained. Along with peak ground acceleration, we evaluated the potential of sand liquefaction in various layers and proposed a relationship between dam fissures and sand liquefaction. Our results suggest that sand liquefaction occurred in the silty sand layer 0–3 m beneath the dam foundation. Sand liquefaction occurs behind the dam, resulting in uneven settlement of the dam foundation, making the horizontal deformation of the backslope of the dam significantly larger than the foreslope of the dam. Using numerical simulations, we found that sand liquefaction behind the dam can cause different horizontal deformation vectors (maximum deformation is ∼7.45 cm) in the dam foreslope and backslope, which cause the dam to rotate in the downstream direction. Large fissures also formed on the dam crest.
Cost-Sensitive LightGBM-Based Online Fault Detection Method for Wind Turbine Gearboxes
Authors: Tang Mingzhu , Zhao Qi , Wu Huawei , Wang Zimin
Published: August 2021

In practice, faulty samples of wind turbine (WT) gearboxes are far smaller than normal samples during operation, and most of the existing fault diagnosis methods for WT gearboxes only focus on the improvement of classification accuracy and ignore the decrease of missed alarms and the reduction of the average cost. To this end, a new framework is proposed through combining the Spearman rank correlation feature extraction and cost-sensitive LightGBM algorithm for WT gearbox’s fault detection. In this article, features from wind turbine supervisory control and data acquisition (SCADA) systems are firstly extracted. Then, the feature selection is employed by using the expert experience and Spearman rank correlation coefficient to analyze the correlation between the big data of WT gearboxes. Moreover, the cost-sensitive LightGBM fault detection framework is established by optimizing the misclassification cost. The false alarm rate and the missed detection rate of the WT gearbox under different working conditions are finally obtained. Experiments have verified that the proposed method can significantly improve the fault detection accuracy. Meanwhile, the proposed method can consistently outperform traditional classifiers such as AdaCost, cost-sensitive GBDT, and cost-sensitive XGBoost in terms of low false alarm rate and missed detection rate. Owing to its high Matthews correlation coefficient scores and low average misclassification cost, the cost-sensitive LightGBM (CS LightGBM) method is preferred for imbalanced WT gearbox fault detection in practice.