bluuebunny/crossref_metadata_2025 huggingface dataset:
An alternative multimodal treatment is effective and safe for migrain
Authors:   St. Petersburg State University, Churilov Leonid , de Carvalho Jozélio ,   Institute for Health Sciences, Federal University of Bahia, Lerner Aaron ,   Chaim Sheba Medical Center, Marques Natalia ,   VP Nutrição Funcional
Published: June 2022

The objective of the article was to evaluate an alternative approach for migraine. The patients received an alternative multimodal approach (AMA) involving nutraceuticals, melatonin, and dietary changes. Six patients were included in the study. Comorbidities were observed in all patients and included hypertension, depression, anxiety, diabetes, asthma, silicone breast implants, and allergic rhinitis. Sleep disorders were observed in 67 % of the patients. Interestingly, after applying AMA, there was a remarkable improvement in all participants. Vitamin D levels surged significantly, and sleep improved in all patients with sleep disturbances. The number of days with migraine was reduced significantly. An improvement of VAS well-being was observed after AMA, and a reduction of the VAS migraine pain was noted. All migraineurs, except one, suspended the conventional preventive drugs for migraine. An AMA is effective and safe, without any side effects for migraine prevention and therapy.
Life support training: Looking for target audience (a pilot study)
Authors:   Krasnoyarsk State Medical University, Arshukova Irina , Dugina Tatiana ,   Krasnoyarsk State Medical University, Akulin Igor ,   St. Petersburg State University, Dobretsova Elena ,   St. Petersburg State University
Published: June 2022

There are many different emergency cases (besides road traffic incidents) in which the outcome for the affected person depends on the timing of the relevant first aid. One of the possibilities to improve the situation is to train a certain population of first aid skills. Identify the audience which is more appropriate to teach first aid skills to be able early to recognize a medical emergency and provide first aid correctly. First aid knowledge and skills of the participants were detected by a questionnaire in 2020. Data were analyzed using SPSS Version 22, p < 0.05. Four hundred and thirty loyal citizens of Krasnoyarsk, Russia, participated in classes. The training led to the significant improvement in the first aid knowledge and skills of the participants (before-and-after study). The citizens who have already witnessed an emergency case realize the opportunity of the emergency situation and their responsibility for the outcome better than the others. The regular first aid classes conducted by the medical community members for people of 30–45 years old with a higher educational level can significantly influence the number of favorable outcomes of emergency out-of-hospital cases.
Medialinguistic studies of PR-speech: Domestic experience
Authors:   St. Petersburg State University, Bykova Elena V.
Published: June 2022

The article provides an overview of Russian articles on media linguistics. In the articles, PRspeech is described in terms of media linguistics. The purpose of the article is to present a spheral approach to the study of PR activities. PR-speech is described as an applied communication technology that serves the administrative, economic, socio-cultural, commercial and political activities of subjects in a highly competitive media environment. In the article, the types of PR-discourses are identified by induction, their typological and genre forms are defined. The review showed that the PR media style is determined by extralinguistic factors of political, commercial or cultural and educational activities, the content and subject of publications, the goals of communication, and the forms of communication with the addressee. PR-discourse can be divided into four types: administrative-economic, political, commercial and cultural-educational. Each discourse has a specific genre-typological system, which helps to optimize communication between the customer and the performer in the implementation of the contract and is an indicator of the effectiveness of communication in a professional environment. The author comes to the conclusion that the metalanguage of PR-speech in the categories of media linguistics demonstrates stability and proves that the institutionalization of this direction in the field of education and professional activity has taken place and is included in the register of scientific specialties “Media Communications and Journalism”.
Advertising as an example of media persuasiveness with the use of modern types of narration
Authors:   The Pontifical University of John Paul II, Cymanow-Sosin Klaudia , Cymanow Piotr ,   University of Agriculture in Krakow, Ciechanowski Marcin ,   The Pontifical University of John Paul II
Published: June 2022

The purpose of this article is to present the main persuasive function of various types of narratives based on the analysis of messages designed to influence and impel to make a decision. An additional purpose is to show that different narrative forms were used thoughtfully based on the research into intended recipient groups. The used methodology of narrative analysis in relation to media messages, the function of which is persuasion, was created on the basis of the methodology of content analysis in mediametric studies of the discipline of social communication and media, as well as related sciences, for example, visual, linguistic or semiological analysis. The relevance of the study is confirmed by the use of fresh material taken from current ratings conducted by network analysts regarding the most popular advertising messages in the Internet space and modern tools in the field of neuroscience. This made it possible to single out such types of narratives as cathectic, storytelling, celebrity, gaming and amplified narratives. Among the analyzed messages, including commercials and social campaigns, the authors highlight their distinctive features and ways of using them in the field of language and images, which makes it possible to categorize any multimodal persuasive messages, and facilitates the interpretation of this type of messages. Demonstrating the persuasiveness of the narrative as an integral feature of all messages in advertising communication leads to the conclusion that the purpose of using the narrative is to create tension and dynamics that strongly affect the viewer. Ultimately, the reason for its use is not only a reference, but also a description of the world. The narrative also has significant axiological and philosophical goals.
TOP MANAGEMENT OF TOWN-FORMING ENTERPRISES AND LEGISLATURES OF SMALL TOWNS: PERSONS MATTER
Authors:   Institute of Sociology of the Federal Center of Theoretical and Applied Sociology of the Russian Academy of Sciences, Chirikova Alla , Ledyaev Valeri ,   HSE University
Published: June 2022

The article presents the outcomes of an empirical study in three small towns of the Russian Federation in 2012-2015 and 2019-2020. The main empirical material was obtained through in-depth interviews (101 interviews in total) with the main actors of local politics. The study showed that in all communities the leadership of town-forming enterprises has a substantial potential to influence decision-making process. However, the degree and nature of their involvement in urban politics varies significantly - from active involvement to leaving. In both cases, the interests of enterprises were taken into account by the leadership of the legislatures, which either directly consisted of representatives of the enterprises, or from the very beginning positioned itself as their partner. When the local representative government is headed by representatives of big business, the possibilities for exercising control over the actions of the executive branch increase. The study showed that town legislatures are a platform for reconciling the interests of big business and the executive branch, without which the participation of big business in the local political processes would be behind the scene and informal. The possibility of turning the legislature into a platform for coordinating interests directly depends on the personal qualities of town and business leaders, their authority and understanding of the importance of cooperation. In the absence of this, the legislature will not be able to successfully participate in the elaboration of the community development strategy. The study showed that the company's desire to coordinate its actions with the executive branch does not necessarily lead to a clear dominance of the company over municipal structures, and the real partnership between the two main participants in urban politics largely depends on the personal factor.
AREAS OF INTERACTION BETWEEN DIGITAL CORPORATIONS AND THE GOVERNMENT IN THE POLITICAL SPHERE OF RUSSIA
Authors:   The Herzen State Pedagogical University of Russia, Zaitsev Stanislav
Published: June 2022

The widespread use of the Internet, the desire of leading world powers to implement the concept of the digital economy, and the scientific and technological progress in this area have led to an increasing influence of large digital corporations. The features of such corporations are the development of products, services, and infrastructure that ensure further digitalization of various spheres of society, as well as the use of a “platform” business model by companies. The increase in financial resources of digital corporations and their dominant position in the development of technologies are a qualitative reserve for influencing political processes: spreading fake news or to build communication between candidates and citizens during election campaigns; the use of products of digital corporations by activists to mobilize and coordinate mass protests; and participation of large corporations in the implementation of government programs for the digitalization of the public sector. The activities of digital corporations, thanks to the distribution of their products, have led to a change in a number of sectors of the economy (passenger transportation, trade, hospitality, advertising, etc.) and exposed the problems that states, as key political actors, will have to solve in the near future. Thus, the state needs to resist digital corporations in their desire to monopolize markets, ensure the security of citizens' personal data, and reduce the negative consequences of individuals using digital products and services. The article examines the key aspects of interaction between the state and digital corporations in Russia. The author highlights the main areas of cooperation and conflict between the state and digital corporations, based on an analysis of the most indicative and relevant cases.
The basics of Polish labour law
Authors:   Adam Mickiewicz University, Skąpski Michał
Published: June 2022

Polish legal system recognizes the difference between labour law and employment law. Labour law is the notion formally recognized by the name of its basic legal act — the Labour Code. Labour law regulates only part of the entire labour market, limited to subordinate forms of work conduct. Employment law is a wider notion, which has scientific rather, than legal basis. It contains labour law within, together with all other employment forms, such as civil contracts for services, self-employment etc. The article discusses the basic regulations of polish labour law. Remarks on polish labor law development after economic system change from centrally regulated to market economy introduce to the topic. After that the sources of law were presented. Those are particularly important for labour law system, which includes not only common sources, but also particular ones, like collective agreements. The article concentrates on presentation of polish individual labour law regulations which are the core of the employment system. This is the regulation of employment contract, which is contained mostly in the Labour Code. This part of article undertakes issues of employment contract types, forms, obligations of the parties and termination. Working time systems and limitations, guarantees of free time presented in the article, are very influential for the whole social system. The article presents also some atypical forms of employment, used in Poland, such as telework, temporary work and self-employment. At the end text presents the basic regulations of collective labour law: workers and employers representations and collective disputes.
Beneficial effect of climate change on wheat yield and water footprints in the Middle-Manyame sub-catchment, Zimbabwe
Authors: Govere Simbarashe , Nyamangara Justice , Nyakatawa E. Z.
Published: June 2022

Climate change is a major concern in wheat agroecosystems as it can affect productivity and crop water use. This study used the AquaCrop model to evaluate climate change impacts on the wheat yield, crop water use and water footprint of wheat production in the Middle-Manyame sub-catchment of Zimbabwe. Climate scenarios were based on simulations from the NCC-NorESM1-M, CCCma-CanESM2 and MOHC-HadGEM2-ES General Climate Models downscaled using three Regional Climate Models (RCA4, RegCM4 and CRCM5) under two Representative Concentration Pathways (RCP4.5 and RCP8.5). The results showed that, compared to the baseline climate (1980–2010), yield may increase by 22.60, 29.47 27.80, and 53.85% for the RCP4.5 2040 s, RCP4.5 2080 s, RCP8.5 2040 s and RCP8.5 2080 s scenarios, respectively. Crop water use may decrease by 1.68, 1.25, 3.7 and 6.47%, respectively, under the four scenarios, respectively. Consequently, the blue water footprint may decrease by 19, 23, 24 and 38%, respectively, under the four scenarios. Sensitivity analysis attributed the increase in yields and the decrease in crop water use to the CO2 fertilization effect, which had a dominant effect over high-temperature effects. The results suggest that future wheat yields could be enhanced while crop water use is reduced because of climate change. However, the realization of these benefits requires farmers to adapt to climate change by adopting recommended agronomic practices and farm input rates that are consistent with those used in the modelling approach of this study.
Francesco Filelfo e gli Jagelloni: un umanista italiano sulla scena europea
Authors: Costanza Salvatore
Published: June 2022

Francesco Filelfo (Tolentino 1398- Florence 1481) was an Italian humanist who studied Greek in Padua, Venice and Constantinople, where he lived during his youth (1420-´27). He is known for his giant Collection of Latin and Greek Letters in 48 books. He also became acquainted with the most prominent personalities of philology, arts and politics at his time. Among them, we must count Władysław II Jagiełło (Vilnius 1362 - Gródek 1434), the granduke of Lithuania (1377-1434) and then king of Poland (since 1386). Filelfo encountered the old king in Buda at the Emperial Diet (1423), in which he took part as personal secretary of the Byzantine ruler John VIII Palaiologos. The Polish king  was impressed by Filelfo´s unusual culture and brilliance so to invite him at his fourth marriage with Zofia Holsańska (ca. 1405-1461). The Italian humanist went to royal wedding held in Kraków, where he pronounced an official epitalamium, as he proudly writes to Władysław III Jagiełło born from this union. He sent this long letter to the young king of Poland just on the eve of the battle in Warna (1444), in which the latter heroically died fighting with Turks. Filelfos epistle to Władysław III influenced Polish humanists such as Albertus Brucius and Jan Ursyn. It is interesting to remark the role that Filelfo assigned to Polish nation as defender of Freedom against Ottoman expansion into Europe.
O perswazyjnej funkcji wina w narracjach biblijnych i mitologicznych
Authors: Kucz Anna
Published: June 2022

The aim of the present article is to outline a few chosen passages of ancient literature, in which wine – deliberately used for persuasive purposes – influenced the literary characters’ behaviour and thus shaped their physical reality. In these narratives, wine has a double effect: it can cheer people up, but it can also tame them with its strength.
Uzaktan eğitime yönelik ortaokul öğrencilerinin görüşlerinin incelenmesi üzerine nitel bir çalışma: Metaforik algıların incelenmesi
Authors: Çakır Ergün , Er Emre
Published: June 2022

Bu araştırmanın amacı, öğrencilerin uzaktan eğitim kavramına ilişkin metaforlarını ortaya çıkarmaktır. Araştırmanın çalışma grubunu, kolay örnekleme yöntemiyle seçilen ve 2020-2021 yılları arasında Ankara'da öğrenim görmekte olan 64 ilköğretim öğrencisi oluşturmuştur. Verilerin analizinde içerik analizi teknikleri kullanılmıştır. Elde edilen bulgulara göre dört kategori altında otuz sekiz metafor oluşturulmuştur. Öğrenci görüşlerinde ekonomi, duygu, teknolojik/akademik ve başa çıkmanın önemi vurgulanmıştır.
Intramolecular Processes and Their Applications in Prodrugs Approaches- Experimental and Computational Studies
Authors: Karaman Rafik , Jumaa Salma , Awwadallah Heba , Salah Samya , Khawaja Yahya , Karaman Donia
Published: June 2022

This review supplies the reader with a detailed overview on the utilization of intramolecular processes for a design and synthesis of prodrugs. It is well known that a respected number of drugs suffer from low bioavailability, toxicity, unpleasant taste and presystemic first-pass metabolism which result in drug inactivation. The classical prodrug approach in which the linkage attaching the parent drug to its non-toxic linker and cleaved by in vivo enzyme’s catalyzed reactions has proven its success in solving toxicity and bioavailability related issues. On the other hand, prodrugs based on chemical interconversion in which the prodrug releases the corresponding active parent drug via inter or intramolecular chemical process in the absence of an enzyme is considered as a better alternative approach since the prodrug cleavage is not dependent in the efficiency or quantity of the enzyme catalyzes the interconversion of the prodrug. Examples of successful prodrugs using the chemical approach via intramolecular processes such as cyclization reactions are illustrated as well.

In addition, another part of this review is devoted to cover reported studies on enzyme models and their utilization for the design and synthesis of a variety of novel prodrugs. In this approach, computational calculations using DFT and MM methods were exploited and correlations between experimentally determined and computed values of the rate-limiting step in the studied intramolecular processes were utilized in the prodrugs design. Selected examples of the designed prodrugs include aza-nucleosides for the treatment of myelodysplastic syndromes, the anti-Parkinson’s agent dopamine, the anti-viral acyclovir, the anti-malarial atovaquone, and statins for lowering cholesterol levels in the blood, the antihypertensive atenolol, the antibacterial cefuroxime, the anti-bleeding tranexamic acid, the decongestant phenylephrine, and the pain killer paracetamol.
Anti-Monopoly and Competition Laws - Impact on the Indian Pharmaceutical Industry
Authors: Kaushik Prerna , Tripathy Swagat , Sharma Rishi , Dureja Harish
Published: June 2022

Background:

Competition is a process of economic race between market participants to draw clients. The Indian competition law establishment is an early administration. Before the enactment of the Competition Act in May 2002, Monopolistic and Restrictive Trade Practices (MRTP) Act was the active law that managed certain parts of the opposition.

Objective:

This manuscript highlights the purpose of competition laws for grappling with the monopolies and restrictive trade practices with a particular focus on pharmaceuticals.

Conclusion

The Competition Act highlights the main features of new competition law which put back the old MRTP act and also lets in the proscription of anti-competitive treaties, prevention of misuse of dominance and combinations which prove detrimental to the competition in the market.
Penggunaan Data Satelit TRMM terhadap Stasiun Curah Hujan di WS Noelmina
Authors: Nomnafa Forisman R. , Krisnayanti Denik Sri , Ramang Ruslan , Udiana I Made
Published: June 2022

Penelitian ini bertujuan untuk memperoleh data curah hujan dari TRMM dan pos hujan yang dapat dipakai pada analisis hidrologi. Analisis ini dilakukan pada 24 data pos hujan yang dikunci oleh grid TRMM dengan resolusi 0,25° x 0,25°. Dalam setiap grid TRMM terdapat minimal 1 data pos hujan sehingga berdasarkan persebarannya pada penelitian ini terdapat 8 grid TRMM. Hasil yang diperoleh adalah nilai koefisien korelasi pada basis hujan bulanan sebesar 0,3218 – 0,9351. Nilai RMSE pada basis hujan bulanan sebesar 69,46 – 856,25. Nilai error pada basis hujan harian maksimum tahunan (HHMT) sebesar 0,0597 – 1,1138. Nilai error pada basis hujan harian sebesar 0,0023 – 0,0321. Data curah hujan yang lolos uji karakteristik hujan rencana ialah data yang memiliki nilai R100/R2 antara 1,5–3,4 serta grafik lengkung faktor pertumbuhannya memiliki trend yang relatif sama dengan data hujan lainnya. Data satelit yang lolos uji karakteristik hujan rencana ialah yakni TRMM I, II, III, IV, V, VI dan VIII. Pos hujan yang lolos uji karakteristik hujan rencana yakni Nifukani, Nule, Kesetnana, Oinlasi, Tilong, Lasiana, Penfui, Tarus, Oeletsala, Naibonat, Tubutesbatan, Raknamo, Camplong, Batuliti, dan Baun.
THE RELEVANCE OF VOCATIONAL SCHOOL CURRICULUM TO THE INDUSTRIAL WORLD DEMANDS: PERCEPTION OF ACCOUNTING TEACHERS OF VOCATIONAL SCHOOLS IN SLEMAN
Authors: Putri Ananda Normalita , Widayati Ani
Published: June 2022

This research discusses the vocational school majoring in accounting about the relevance of the vocational school curriculum to the demands of the Industrial Business World. This research is quantitative descriptive research. The analysis technique used is descriptive analysis with a percentage. The results of this research indicate that: (1) Accounting Vocational Teachers in Sleman Regency are very good at knowing the needs of the industrial world of business. (2) Perception of Vocational School Teachers in Accounting in Sleman Regency on the Curriculum Relevance seen from (a) The objectives of the Vocational Accounting curriculum used so far are already relevant to Industrial Business World requests. (b) The accounting learning materials at the Vocational School used so far are already relevant to the Industrial Business World requests.
PENGEMBANGAN BAHAN AJAR INTERAKTIF BERBASIS M-LEARNING PADA MATA PELAJARAN ADMINISTRASI PAJAK
Authors: Kriswanto Daniel Bangkit
Published: June 2022

Penelitian ini bertujuan untuk 1) menganalisis pengembangan Bahan Ajar Interaktif berbasis M-Learning 2) menganalisis kelayakan berdasarkan penilaian para ahli 3) menganalisis respon peserta didik terhadap Bahan Ajar Interaktif berbasis M-Learning pada mata pelajaran Administrasi Pajak kelas XII Akuntansi SMKN 10 Surabaya.. Model pengembangan penelitian ini menggunakan model pengembangan ADDIE yang terdiri dari Analysis, Design, Development, Implementation dan Evaluation. Teknik pengumpulan data dalam penelitian ini menggunakan lembar telaah dan validasi para ahli yaitu ahli materi, ahli grafis dan ahli bahasa serta angket respon peserta didik yang dianalisis dengan teknik deskriptif kauntitatif dengan bentuk presentase yang diperoleh dari perhitungan skor menurut skala Linkert dan skala Guttman. Hasil penelitian menunjukkan tingkat kelayakan isi sebesar 92% dengan kriteria sangat layak, kelayakan penyajian sebesar 92% dengan kriteria sangat layak, kelayakan bahasa sebesar 79% dengan kriteria layak, kelayakan kegrafikan sebesar 97% dengan kriteria sangat layak. Dari keseluruhan aspek kelayakan diperoleh rata-rata sebesar 90% dengan kriteria sangat layak. Untuk angket respon perserta didik memperoleh hasil dengan rata-rata sebesar 96% dengan kriteria sangat dipahami.Sehingga, dapat dikatakan bahwa Bahan Ajar Interaktir berbasis M-Learning yang dikembangkan sangat layak untuk digunakan sebagai bahan ajar pendukung pada mata pelajaran Administrasi Pajak.
INTERNET BANKING DAN CYBER CRIME : SEBUAH STUDI KASUS DI PERBANKAN NASIONAL
Authors: Arofah Nida Rafa , Priatnasari Yeni
Published: June 2022

Cyber crime merupakan kejahatan yang memanfaatkan perkembangan teknologi komputer khususnya internet. Internet banking adalah suatu bentuk pemanfaatan media internet oleh bank untuk mempromosikan dan sekaligus melakukan transaksi secara online, baik dari produk yang sifatnya konvensional maupun yang baru. Penelitian ini bertujuan untuk mengetahui pengaruh Penggunaan Internet Banking terhadap Cyber Crime di Wilayah Tegal khususnya pada nasabah PT. Bank Rakyat Indonesia (Persero), Tbk Kantor Cabang Tegal. Teknik pengumpulan data yang digunakan adalah dengan metode pengumpulan kuesioner. Populasi dalam penelitian ini adalah pengguna fasilitas internet banking di Wilayah Tegal. Sampel sebanyak 100 responden yang ditentukan dengan teknik simple random sampling. Teknik analisis yang digunakan adalah Uji Validitas, Uji Reliabilitas, Uji Normalitas, Uji Regresi Sederhana dan Uji Hipotesis. Hasil perhitungan nilai koefisien regresi sebesar 0,261 menyatakan bahwa setiap kenaikan Penggunaan Internet Banking sebesar 1 satuan akan menaikan Cyber Crime sebesar 0,261 satuan. Hal ini berarti model tersebut adalah positif. Selain itu, nilai probabilitas signifikansi Penggunaan Internet Banking sebesar 0,004 yang lebih kecil dari 0,05, maka dapat dinyatakan bahwa Penggunaan Internet Banking berpengaruh signifikan terhadap Cyber Crime di Wilayah Tegal. Maka dapat disimpulkan bahwa terdapat pengaruh positif dan signifikan Penggunaan Internet Banking terhadap Cyber Crime di perbankan wilayah Kota Tegal.Kata Kunci : Internet Banking, Cyber Crime, industry perbankan, lembaga keuangan, teknologi
PENGEMBANGAN MEDIA PEMBELAJARAN BERBASIS AUDIO-VISUAL UNTUK E-LEARNING MATA KULIAH KURIKULUM DAN PEMBELAJARAN AKUNTANSI
Authors: Siswanto Siswanto , Aghni Rizqi Ilyasa , Siregar Merinda Noorma Novida
Published: June 2022

Tujuan dilaksanakannya penelitian ini adalah untuk mengetahui apakah: 1) Mengetahui tahap pengembangan serta menghasilkan media pembelajaran berbasis audio-visual untuk e-learning mata kuliah kurikulum dan pembelajaran Akuntansi, 2) Menghasilkan media pembelajaran berbasis audio-visual untuk e-learning yang layak pada mata kuliah kurikulum dan pembelajaran Akuntansi dari segi ahli, praktisi, dan mahasiswa. Penelitian ini merupakan penelitian pengembangan dengan teknik analisis data deskriptif. Data penelitian diperoleh dari hasil penilaian ahli (validator) terhadap perangkat pembelajaran yang meliputi media pembelajaran yang dikembangkan berupa modul PDF, powerpoint bersuara, dan video animasi. Analisa data dilakukan untuk mengetahui kelayakan dari media pembelajaran yang dikembangkan dengan mengkonversi data hasil uji coba pada skala lima. Hasil penelitian dan pengembangan ini adalah: (1) pengembangan media pembelajaran berbasis audio-visual untuk e-learning mata kuliah kurikulum dan pembelajaran akuntansi. Model pengembangan yang digunakan yakni Model 4 D, yang terdiri dari Define, Design, Development, dan Disemination. (2) Kelayakan media pembelajaran menurut ahli materi, ahli media, dan dosen pengampu baik untuk media modul PDF, PPT bersuara, dan video animasi ditinjau dari berbagai aspek penilaian masuk dalam kategori “sangat layak”. (3) Berdasarkan hasil respon mahasiswa terhadap penggunaan berbagai media pembelajaran tersebut pada kategori sangat layak untuk modul PDF, sedangkan kategori layak untuk media PPT bersuara dan video animasi. Kata Kunci : Media Pembelajaran, Audio-Visual, Kurikulum dan Pembelajaran Akuntansi
THE INFLUENCE OF BUSINESS ETHICS EDUCATION, RELIGIOSITY, AND LOCUS OF CONTROL TOWARD STUDENT MORAL JUDGMENT
Authors: Susanti Ririn , Setyorini Dhyah
Published: June 2022

This research aimed to know the influence of business ethics education, religiosity, and locus of control toward student moral judgment. The population of this research was 115 students in Accounting and Accounting Education Yogyakarta State University. The data collection technique used in this research was questionnaire. The data analysis technique used multiple regression analysis. The research showed that there is a positive and significant influence of business ethics education toward student moral judgment. Conversely, the result showed that religiosity and locus of control have no significant influence toward student moral judgment. The research identifies that student moral judgment can be explained by the variable of business ethics education, religiosity, and locus of control on 11,60%. In comparison, the remaining 88,40% is influenced by other variables that were not examined in this study.
THE DEVELOPMENT OF "ACCESS" ANDROID BASED LEARNING MEDIA IN THE ACCOUNTING CYCLE MATERIAL
Authors: Hanny Agata Bonfilia , Fajar Muhammad Andryzal
Published: June 2022

This research is intended to produce "Access" Android Based Learning Media in The Service Company Accounting Cycle. This is a Research and Development type of research that includes four phases, namely: Analysis, Design, Development, and Implementation. The feasibility of the learning media was assessed by material expert, media expert, accounting learning practitioner and students, using questionnaires. The quantitative research data were analyzed using the quantitative-descriptive analysis technique. The final product of this research is a learning media in the form of Android Application. The media includes material, questions, and game. The results of this research indicate; (1) “Access” android-based learning media development through 5 phases, they were: Analysis, Design, Development, and Implementation. (2) The development of “Access” android based learning media on expert evaluation: a) Material expert got score 3,66 with “Very feasible” category, b) Media expert got score 2,89 with category “Feasible”, c) Accounting learning practitioner got score 3,79 with the category “Very Feasible”. (3) Students assessment to media got average score 3,46 with the category “Very feasible”. The developed “Access” android-based learning media shows that it is very feasible as the learning media.
MODERN THERAPY OF TYPE 2 DIABETES MELLITUS USING PHARMACOECONOMIC ANALYSIS
Authors: Kravchun N. A. , Karachentsev Yuri , Kozakov Alexandr , Romanova I. P. , Cherniavskaya Irina , Karamyshev D. V. , Nemchenko A. S.
Published: June 2022

he clinical efficacy of Tripride was studied by pharmacoeconomic analysis. It was found that the appointment of the drug Tripride reduces the level of glycosylated hemoglobin as well as the simultaneous appointment of three drugs, and requires less material costs. Tripride also helps to improve lipid metabolism and reduce body weight.
DYNAMICS OF PARAMETERS OF SEXUAL DEVELOPMENT AND LEVELS OF TESTOSTERONE IN THE BLOOD UNDER THE INFLUENCE OF ANDROGENOTHERAPY IN PATIENTS WITH PRIMARY HIPOGONADISM
Authors: Bondarenko Volodymyr , Minukhin Andriy , Skornyakov Evgeniy
Published: June 2022

The parameters of sexual development and the levels of testosterone in the blood before and after 36 weeks of testosterone undecanoate or omnadren therapy in young men with primary hypogonadism were studied. It was found that a more significant masculinizing effect was observed after three injections of testosterone undecanoate with an interval of 12 weeks. It has been shown that the positive effect of treatment with testosterone undecanoate is due to the maintenance of the level of testosterone in the blood in the eugonadal range.
THE USE OF CEFACEL IN THE TREATMENT OF CHRONIC AUTOIMMUNE THYROIDITIS
Authors: Prylutsky A. S. , Kasyarum V. P. , Prylutska O. A. , Degonsky A. I. , Knyshevska L. A. , Bakhtiyarova A. A. , Pyskureva A. V. , Vasylieva V. V. , Galkina N. S. , Lesnichenko D. A.
Published: June 2022

The levels of specific autoantibodies to thyroperoxidase and thyroglobulin were studied in 40 patients with chronic autoimmune thyroiditis before and after treatment with sodium selenite (Cefasel 200 μg per day). Treatment with Cefasel for three months against the background of levothyroxine therapy caused a significant decrease in the level of antibodies to thyroperoxidase and thyroglobulin.
HYPOTHYROIDISM: EPIDEMIOLOGY, DIAGNOSTICS, TREATMENT EXPERIENCE
Authors: Kravchun N. A. , Cherniavskaya Irina
Published: June 2022

The efficiency of the phytocomplex "Zobofit" was studied in patients with hypothyroidism. It is shown that the use of "Zobofit" improves the structure of the thyroid gland, normalizes the indicators of the functional activity of the pituitary-thyroid system. It is possible to reduce the dosage of thyroid hormones when using “Zobofit” in the complex therapy of hypothyroidism
INFLUENCE OF DIFFERENT CRYOPROTECTORS ON RESPIRATORY ACTIVITIES OF SPERM OF TURKEYS AND ROOSTERS
Authors: Ovsyannikova T. N. , Linnik T. P. , Martyniuk I. M. , Kovalenko A. A. , Prokopchuk G. S.
Published: June 2022

The mitochondrial respiratory activity of sperm from roosters and turkeys (as models) under cryopreservation conditions in the presence of various cryoprotectants was studied. It has been demonstrated that 1,2-propanediol is the optimal cryoprotectron for sperm cells, both native and after freezing - warming.
INFLUENCE OF ATMOSPHERIC AIR POLLUTANTS ON THE PREVALENCE OF ENDOCRINE DISEASES IN CHILDREN AND ADOLESCENTS IN THE INDUSTRIAL CITY
Authors: Sincere O. M. , Kapranov S. V. , Kapranova T. S.
Published: June 2022

The influence of air pollutants on the prevalence of endocrine diseases in children and adolescents in an industrial city with large productions of ferrous metallurgy and coke chemistry has been studied. It is established that the prevalence of endocrine diseases, disorders

nutrition and metabolism, as well as the prevalence of thyroid pathology is higher in children attending children's educational institutions in areas with high levels of pollution

atmosphere, compared with their peers who visit children's institutions in neighborhoods with more

clean air. Preventive recommendations have been developed.
INFLUENCE OF TAURINE-CONTAINING DRUG ON THE DEVELOPMENT OF VISCERAL OBESITY IN OVARIECTOMED RATS WITH SYNDROME INSULIN RESISTANCE INDUCED BY A HIGH FAT DIET
Authors: Zvyagina T. S. , Gorbenko Nataliia
Published: June 2022

The effect of taurine-containing drug on the development of visceral obesity in rats was studied

with the syndrome of insulin resistance on the background of estrogen deficiency, which was kept on a high-fat diet. It was found that oral administration of taurine-containing drug, in the absence of

stimulating effect on proliferative processes in the uterus, improves tolerance to

carbohydrates and sensitivity to insulin, inhibits the development of abdominal obesity, weight gain

body. The obtained results substantiate the prospects of using taurine-containing drug for pharmacological correction of the main components of postmenopausal metabolic

syndrome.
CAUSES OF FAILURES IN COMPENSATION FOR PATIENTS WITH TYPE 2 DIABETES. THE ROLE OF POSTPRANDIAL GLYCEMIA
Authors: Doskina E. V.
Published: June 2022

Causes of failures in compensation for patients with type 2 diabetes. The role of postprandial glycemia
MORPHOLOGICAL AND MORPHOMETRIC CHARACTERISTICS OF THYROID CANCER IN POSTMENOPAUSAL WOMEN WITH AUTOIMMUNE THYROIDITIS
Authors: Goncharova Olga , Goydenko N. I.
Published: June 2022

We study an arbitrary selection of material biopticheskogo thyroid women with autoimmunethyroiditis of reproductive age and postmenopausal periods. Thyroid postmenopausal women withautoimmune thyroiditis is characterized by significant decrease of thyroid follicles, their deformity,atrophy, degenerative changes pave the follicle epithelium. Is the formation of lymph follicles withgermenativnymi centers, greater than in women of reproductive age, there is the presence of scleroticfields in the interfollicular space.
CHARACTERISTICS OF PFTIENS WITH THYROID CANCER ACCOMPANIED BY BENIGN THYROID PATHOLOGY: AN ANALYSIS OF 677 CASES
Authors: Hulchiy M. V. , Dinets A. V.
Published: June 2022

Results of the study revealed the oncological process to show less favorable clinicopathologicalfeatures in patients with thyroid cancer (TC) only as compared to TC comorbid by bening thyroidneoplasms. It determines that TC accompanied by other thyroid lesions exhibited better prognosticfeatures such as low proportion of male patients, smaller size of primary tumor due to elevated numberof cases with thyroid microcarcinoma, low proportion of biologically aggressive medullary TC. Theage over 45 years was found to be only one unfavorable factor for patients with TC comorbid beningthyroid lesions.
ANALYSIS OF BEHAVIORAL AND NEUROCHEMICAL EFFECTS OF SEROTONINOTROPIC SUBSTANCES IN FEMALE RATS
Authors: Fedotova Yu. O. , Frolova G. O.
Published: June 2022

The aim of the present work was to perform a comparative analysis of inﬂuence of chronic admin-istration of 5-HT 2B/2C receptor agonist (m-CPP) and 5-HT 2A/2C receptor antagonist — ketanserineon anxiety-like behavior, on gonadal hormones levels in the blood and on expression on mRNAsof 5-HT 2C - and 17β-estradiol receptors in the hippocampus and amygdala of the adult female ratsduring ovary cycle. Ketarserine administration rendered an anxiolytic-like action in rats with estrousand proestrous phases, simultaneously the inhibiting of pituitary-ovary system, and the stimulating ofmRNAs of 5-HT 2C - and 17β-estradiol receptors expression in the hippocampus and amyldala. M-CPPstimulated pituitary-ovary axis, and inhibited expression of mRNA of 5-HT 2C -receptor in the brain.The data obtained indicate a close interaction between ovary hormonal and serotonergic systems ofthe brain in the mechanisms of the anxiety-like behavior.
THE IMPACT OF TAURINE-CONTAINING DRUG ON OXIDATIVE STATUS IN OVARIECTOMIZED RATS WITH METABOLIC SYNDROME
Authors: Zvyagina T. S.
Published: June 2022

The affect of taurine-containing drug «Kratal» on oxidative status of ovariectomized rats withmetabolic syndrome, which have been fed high fat diet, is investigated. It has been established drugadministration per os suppresses development of oxidative stress. Given results are the base for further«Kratal» application for prophylaxis and cardiovascular pathologies treatment in postmenopausalwomen
Absenteeism of diabetics to appointments with an endocrinologist and its relationship with access to health services
Authors: Leal Marcelle Lemos , Santos Neto Edson Theodoro dos , Zandonade Eliana , Sarti Thiago Dias , Cade Nagela Valadão
Published: June 2022

Objective: To analyze the association between absenteeism and access to specialized consultations for diabetics, in the Unified Health System (SUS) in Espírito Santo (ES). Methods: Cross-sectional study conducted using primary and secondary data with 472 diabetics ≥ 18 years old scheduled in consultation with endocrinologist in the System of Regulation Centers of ES. The variables of the dimensions of access - availability, financial viability, and acceptability - were used to estimate the association with absenteeism. Logistic regression was used for the crude and adjusted analyses. Results: An association was found between absenteeism of diabetics and the variables living less than 10 km from the provider (OR: 1.81; 95%CI: 1.16 - 2.82, p = 0.01), need for transportation (OR: 4.89; 95%CI: 2.54 - 9.42, p < 0.001), and having financial expenses to attend the appointment (OR: 2.06; 95%CI: 1.23 - 3.44; p = 0.01). Conclusion: The main barriers of access to health services that contribute to the high prevalence of absenteeism from appointments with endocrinologists can be understood as a proxy for the socioeconomic status of diabetics and show close relationship with the social determinants of health.
Nursing team knowledge assessment instruments about pressure injury: integrative review
Authors: Carreiro Gisele Santana Pereira , Soares Maria Júlia Oliveira Guimarães , Oliveira Simone Helena Santos , Mendonça Ana Elza Oliveira
Published: June 2022

Objectives: to identify in the scientific literature how the assessment of knowledge of the nursing team about pressure injuries is conducted, which instruments are used, and their psychometric properties. Methods: integrative review conducted with 44 scientific articles. The search was conducted between October and December 2021 in the following data sources: BDENF, Cinahl, Lilacs, MEDLINE, Scopus, Google Scholar, and Web of Science, using the strategy in Portuguese: ("lesão por pressão" OR "úlcera por pressão" OR "úlcera de decúbito" OR "escara de decúbito") AND enfermagem AND conhecimento, and, in English, ("pressure ulcer" OR "bed sore" OR "bed sores" OR bedsore OR bedsores) AND nursing AND knowledge. Articles published between 2012 and November 2021 were included, with text available in full, in open access, in English, Portuguese, or Spanish, resulting from original research related to care in the hospital area. Results: The most used knowledge assessment instrument was the P-PUKT and its versions, used in 50% of the studies, followed by the PUKAT and its versions. Three studies also used instruments constructed and validated by the authors, five qualitative studies, and four studies used non-validated instruments. Conclusion: Valid instruments to assess knowledge are essential to identify possible failures in patient care. Heterogeneity in the samples and in the classification criteria of the participants' level of knowledge made it impossible to compare the results obtained in the studies, constituting a limitation.
Three-dimensional analytical solution of the advection-diffusion equation for air pollution dispersion
Authors: Farhane Mehdi , Alehyane Omar , Souhar Otmane
Published: June 2022

We develop a new analytical solution of a three-dimensional atmospheric pollutant dispersion. The main idea is to subdivide vertically the planetary boundary layer into sub-layers, where the wind speed and eddy diffusivity assume average values for each sub-layer. Basically, the model is assessed and validated using data obtained from the Copenhagen diffusion and Prairie Grass experiments. Our findings show that there is a good agreement between the predicted and observed crosswind-integrated concentrations. Moreover, the calculated statistical indices are within the range of acceptable model performance.
 
doi:https://doi.org/10.1017/S1446181122000037
Сучасні підходи до періопераційного лікування пацієнтів з пахвинними грижами (огляд літератури)
Authors: Ushnevych Z.O. , Matolinets N.V. , Khomyak V.V.
Published: June 2022

У статті наведено огляд світових даних про сучасні підходи до періопераційного лікування пацієнтів з пахвинними грижами за принципами швидкого відновлення (ERAS). Алгоритм програми ERAS включає всі доказово обґрунтовані періопераційні елементи, які впливають на швидке відновлення після операції, зменшення частоти ускладнень і потенційну смертність. Для цього виділяють три етапи ведення хворого: передопераційний огляд та обстеження, вибір адекватного методу хірургічного лікування, анестезіологічне забезпечення під час операції і в післяопераційному періоді. Ретельне обстеження пацієнтів перед операцією і виявлення потенційних факторів ризику, пов’язаних із супутніми захворюваннями, є важливими для зниження ризику ускладнень і рецидивів. Ефективне динамічне періопераційне керування болем є необхідною умовою оптимального відновлення після операції. Першим етапом керування болем у рамках концепції ERAS є правильний вибір типу операції. Слід надавати перевагу найменш травматичним операціям, тобто лапароскопічним або ендоскопічним герніопластикам. Відповідно до рекомендацій PROSPECT введення анальгетиків слід почати до і продовжувати під час операції, що дозволить забезпечити достатнє знеболювання в ранньому післяопераційному періоді. Поєднання парацетамолу, нестероїдних протизапальних препаратів і селективного інгібітору циклооксигенази-2 забезпечує добре знеболювання й зменшує використання опіоїдів. Блок поперечного простору живота (TAP-блок) як вид регіонарної анестезії є безпечним для пацієнтів з пахвинними грижами, зменшує післяопераційну потребу в наркотичних анальгетиках, знижує частоту післяопераційної нудоти й блювання та інтенсивність болю. Регіонарна анестезія дозволяє скоротити час перебування хворого в операційній і пов’язана з меншим ризиком затримки сечі в післяопераційному періоді (порівняно з нейроаксіальною анестезією). У післяопераційному періоді слід якнайшвидше активувати пацієнта, а це можливо за умови достатньої аналгезії, що досягається найкраще при поєднанні системних анальгетиків і TAP-блоку. Усім пацієнтам, яким виконують планове хірургічне втручання з приводу пахвинних гриж, слід проводити антимікробну профілактику. Оскільки частина пацієнтів відчувають значні обмеження в повсякденній діяльності внаслідок хронічного післяопераційного пахвинного болю, необхідно враховувати всі фактори ризику виникнення хронічного болю після операції для запобігання його розвитку.
Purification and characterization of thermostable serine alkaline protease from Geobacillus sp. DS3 isolated from Sikidang crater, Dieng plateau, Central Java, Indonesia
Authors: Phon Sotharith , Ningrum Andriati , Witasari Lucia Dhiantika
Published: June 2022

Thermostable proteases that optimally withstand the high‐temperature conditions of thermophilic bacteria could be produced and purified, which would be highly beneficial for use in industry. Geobacillus sp. is a thermophilic bacterium that can be found in various environmental conditions. The goal of this study was to isolate and characterize thermostable serine protease that had been produced by thermophilic Geobacillus sp. strain DS3. The proteolytic index was measured in a solid medium. The expression of protease was optimized by Geobacillus sp. DS3 at 50 °C for 18 h. Targeted protease was purified using ammonium sulfate (40‐60%) and DEAE Sephadex A‐25 resin. Using SDS‐PAGE, the molecular weight of the enzyme was predicted to be around 32 kDa. Purified thermostable protease was highly activated at 70 °C, pH 9.6 stable for 1 h, and inhibited by PMSF. Therefore, this enzyme is classified as a thermostable alkaline serine protease. Its kinetic study revealed specific activity of 0.41 U/mg (Vmax) and 0.25 mg/mL (KM). Overall, a thermostable alkaline serine protease from Geobacillus sp. DS3 showed high activity at high temperatures and alkaline pH, which is vital for application in industries such as leather processing and detergent formulation.
Identification of Incung Characters (Kerinci) to Latin Characters Using Convolutional Neural Network
Authors: Putri Tesa Ananda , Suratno Tri , Khaira Ulfa
Published: June 2022

Incung script is a legacy of the Kerinci tribe located in Kerinci Regency, Jambi Province. On October 17, 2014, the Incung script was designated by the Ministry of Education and Culture as an intangible heritage property owned by Jambi Province. But in reality, the Incung script is almost extinct in society. This study aims to identify the characters of the Incung (Kerinci) script with the output in the form of Latin characters from the Incung script. The classification method used is the Convolutional Neural Network (CNN) method. The dataset used as many as 1400 incung character images divided into 28 classes. In this study, an experiment was conducted to obtain the most optimal model. Showing the results using the CNN method during the training process that the accuracy of the training data reaches 99% and the accuracy of the testing data reaches 91% by using the optimal hyperparameters from the tests that have been done, namely batch size 32, epoch 100, and Adam's optimizer. It evaluates the CNN model using 80 images in words (a combination of several characters) with 4 test scenarios. It shows that the model can recognize image data from scanning printed books, digital writing test data, test data with images containing more than two characters, and check images with different font sizes