bluuebunny/crossref_metadata_2025 huggingface dataset:
An experimental and computational investigation of the effects of volumetric boundary conditions on the compressive mechanics of passive skeletal muscle
Authors: Wheatley Benjamin
Published: November 2019

Computational modeling, such as finite element analysis, is employed in a range of biomechanics specialties, including impact biomechanics and surgical planning. These models rely on accurate material properties for skeletal muscle, which comprises roughly 40% of the human body. Due to surrounding tissues, compressed skeletal muscle in vivo likely experiences a semi-confined state. Nearly all previous studies investigating passively compressed muscle at the tissue level have focused on muscle in unconfined compression. The goals of this study were to (1) examine the stiffness and time-dependent material properties of skeletal muscle subjected to both confined and unconfined compression (2) develop a model that captures passive muscle mechanics under both conditions and (3) determine the extent to which different assumptions of volumetric behavior affect model results. Muscle in confined compression exhibited stiffer behavior, agreeing with previous assumptions of near-incompressibility. Stress relaxation was found to be faster under unconfined compression, suggesting there may be different mechanisms that support load these two conditions. Finite element calibration was achieved through nonlinear optimization (normalized root mean square error <6%) and model validation was strong (normalized root mean square error <17%). Comparisons to commonly employed assumptions of bulk behavior showed that a simple one parameter approach does not accurately simulate confined compression. We thus recommend the use of a properly calibrated, nonlinear bulk constitutive model for modeling of skeletal muscle in vivo. Future work to determine mechanisms of passive muscle stiffness would enhance the efforts presented here.
Time Frequency analysis of data from the Vela Pulsar
Authors: Shandilya Pradyoth H
Published: November 2019

In this article, the procedure to conduct the time-frequency analysis of data recieved from distant pulsars, such as the Vela pulsar is explored. Problems that are encountered and solutions to these problems are also mentioned.
tugas Pemikiran ekonomi dan bisnis
Authors: Gunawan Hensan
Published: November 2019

review jurnal pentingnya inovasi dan kreatifitas era teknologi digital
The role of religion for mindfulness-based interventions: implications for dissemination and implementation
Authors: Palitsky Roman , Kaplan Deanna M
Published: November 2019

Mindfulness-based interventions are increasingly recognized for their efficacy in clinical settings. Because of the historical and social associations of mindfulness-based interventions with spirituality and religion, individual differences in religiosity are likely to play a role in how people perceive these interventions, and may ultimately impact the acceptability and implementation of mindfulness-based techniques. Mindfulness-based interventions’ religious associations are often left unspecified, but when they are stated, they are typically represented as either 1) secular and neutral to religious concerns, or as 2) religiously influenced. Dichotomously presenting MBIs as either religious or secular can undermine the delivery of these interventions, as can failing to address religion or spirituality altogether. We present theory and research that explicates the likely ways in which religion influences the acceptability of mindfulness-based interventions, and provide recommendations for researchers and interventionists that enable them to respond to religious concerns about mindfulness-based interventions.
Facial-width-to-height ratio (fWHR) measured from 2D images using a fully automated method and a manual-landmark-placement method produce very similar results
Authors: Schild Christoph , Bontempi Dennis , Jones Benedict C
Published: November 2019

Facial-width-to-height ratio (fWHR) measured from 2D images using a fully automated method and a manual-landmark-placement method produce very similar results
Análisis de la Inversión en Investigación y Desarrollo en el Panorama Actual de México
Authors: Ulloa Diego Saldaña , Martinez-Pedraza Amanda
Published: November 2019

In this work, We analyze the actual situation ofMexico about the investment in Research and Development.We use actual data to give a better context and we identifyseveral problems that must be resolved. The main topics thatwe analyzed are focused on employment in Research andDevelopment, the brain drain effect, the situation about thepatents in Mexico and the analysis of maquiladora-industryand how is related to Research and Development investment.
The Relation of Competency Evaluating and Designing Scientific Enquiry with Naturalistic Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency evaluating and designing scientific enquiry with naturalistic intelligence.
The Relation of Competency Interpreting Data and Evidence Scientifically and Naturalistic Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency interpreting data and evidence scientifically and naturalistic intelligence. It reveals that they has positive correlation.
The Relation of Competency Interpreting Data and Evidence Scientifically and Verbal Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency interpreting data and evidence scientifically and verbal intelligence. It reveals that they has positive correlation.
Buku Kumpulan Peraturan dan Pedoman LP Ma'arif NU
Authors: Setiawan Adib Rifqi
Published: November 2019

Buku Kumpulan Peraturan dan Pedoman LP Ma'arif NU
The Relation of Competency Interpreting Data and Evidence Scientifically and Logical Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency interpreting data and evidence scientifically and logical intelligence. It reveals that they has positive correlation.
The Relation of Scientific Literacy Competencies and Self‐Determination
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of scientific literacy competencies and self‐determination.
The Relation of Scientific Literacy Competencies and Multiple Intelligences
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of scientific literacy competencies and multiple intelligences.
The Relation of Competency Explaining Phenomena Scientifically and Intrapersonal Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency explaining phenomena scientifically and intrapersonal intelligence. It reveals that they has positive correlation.
The Relation of Competency Evaluating and Designing Scientific Enquiry with Verbal Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency evaluating and designing scientific enquiry with verbal intelligence.
The Relation of Scientific Literacy Competencies and Motivation Components
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of scientific literacy competencies and motivation components.
The Relation of Competency Interpreting Data and Evidence Scientifically and Kinesthetic Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency interpreting data and evidence scientifically and kinesthetic intelligence. It reveals that they has positive correlation.
The Relation of Competency Evaluating and Designing Scientific Enquiry with Logical Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency evaluating and designing scientific enquiry with logical intelligence.
The Relation of Scientific Literacy Competencies and Career Motivation
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of scientific literacy competencies and career motivation.
The Relation of Competency Explaining Phenomena Scientifically and Musical Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency explaining phenomena scientifically and musical intelligence. It reveals that they has positive correlation.
The Relation of Competency Explaining Phenomena Scientifically and Existential Intelligence
Authors: Setiawan Adib Rifqi
Published: November 2019

The goal of this research is to gain the relation of competency explaining phenomena scientifically and existential intelligence. It reveals that they has negative correlation.
The pragmatics of absurdity
Authors: Kiyanskaya O. I. , Feldman D. M.
Published: November 2019

The analysis is focused on the pragmatics of V. Lenin’s articles ‘Party Organization and Party Literature’ [‘Partiynaya organizatsia i partiynaya literatura’] (1905) and ‘How to Ensure Success of the Constituent Assembly (on freedom of the press)’ [‘Kak obespechit uspekh Uchreditelnogo sobraniya (o svobode pechati)’] (1917). Foreign and Russian scholars alike considered the two works as components of the concept of Socialist state literature and journalism, conceived before the Soviet era. Based on examination of the political context, this work proves that Lenin was driven to write the articles by his fight for leadership in RSDRP. In 1905, Lenin obtained control over Novaya Zhizn, the newspaper under M. Gorky’s editorship, and insisted that opponents had to follow his censorship guidelines: the press had to become a propaganda tool rather than a source of income. Twelve years on, Lenin’s principles still reigned.
‘What! From outback steppe villages...’
Authors: Tsimbaeva E. N.
Published: November 2019

The image of Pushkin’s Tatiana has proved magnetic for scholars of Russian literature and spiritual traditions alike. The article offers a look at Tatiana through the eyes of her contemporaries, visualizing her as an active figure in provincial and St. Petersburg aristocratic circles. Tatiana Larina owes her excellent homeschooled education mostly to her own determination and a knack for self-improvement. She is hardly a humble rustic beauty, nor is she oblivious to contemporary intellectual pursuits. The author proves that Tatiana’s transformation into a brilliant socialite is by no means a mere exaggeration by the poet, but naturally follows from her innate talents nurtured in ‘rural solitude’. The study of Tatiana’s evolution is presented in the context of numerous historical facts.
Literature published in BAMlag’s main newspaper Stroitel BAMa
Authors: Smykovskaya T. E.
Published: November 2019

T. Smykovskaya writes about a unique episode of Russian literary history: the development of so-called ‘labour-camp literature’, more specifically, lyrical poetry, published in the camps’ newspapers. The article focuses on BAMlag’s principal paper Stroitel BAMa, which saw publications of works by A. Alving, P. Florensky, A. Tsvetaeva, and other detainees. In her examination of the material, which so far has provoked little to no scholarly interest, the author highlights the key themes, images and subjects of labour-camp literature. Essentially, the article attempts to focus on the yet unknown history of the newspaper Stroitel BAMa, the main printed medium of BAMlag, as well as to describe the paper’s artistic and journalistic paradigm, which defined the literary activities of Svobodlag for a decade. Therefore, the article covers the newspaper’s history from the 1933 competition for its name until the emergence of the poetry section in the mid-1930s; from the Stakhanov theme, omnipresent in ‘free’ and labour-camp poetry alike in 1936, until eulogy of the Soviet leaders in pre-war years.
Twice lived youth of Yaroslav Smelyakov
Authors: Strashnov S. L.
Published: November 2019

The article discusses the interaction of Y. Smelyakov’s (1913–1972) poetry with mass consciousness and describes the major events of the poet’s biography. Milestones on his literary path have been reconstructed, as has his evolution from a carefree lyrical hero into a confident author. The analysis of Smelyakov’s poetry is supplemented with numerous references to everyday Soviet realia. Especially detailed are descriptions of his debut poems, but the author also takes into account the latest interpretation of the poet’s youthful years in the early 1930s. The context of 1920s–1970s Soviet literature is a pivotal element of the analysis. In particular, the author suggests mutual affinity of Smelyakov’s works with the genre of popular sentimental songs, the works of proletarian poets, and the Sixtiers’ poetry. The article recalls the polemics around Smelyakov’s work, especially in the years before the war in 1941 and in the post-Soviet era. Soviet critics often reproached Smelyakov for excessive lyricism, attention to mundane details, and sentimentalism.
The theory and history of ekphrasis. A summary and prospects of research, or, forty-five articles on ekphrasis
Authors: Perlina N. M.
Published: November 2019

The article is devoted to ekphrasis, its historical and literary evolution, as well as aspects of its stylistic, cultural, and ideological origins. The research is based on the versatile collection of The Theory and History of Ekphrasis [Teoriya i istoriya ekfrasisa], which contains a number of previously little known texts and theories on ekphrasis, developed in regions with different ethnic and cultural characteristics. The author spares no effort in the examination of this monograph and, using the observations made by various scholars, discerns a similar development process of cross-cultural and cross-aesthetic transformations and transpositions, which, however, adopts divergent paths. Transpositions, the author suggests, occur in the model of a text awaiting a pictorial interpretation. The article concentrates on the ways to present an image anticipated in a written word, and to generate a new text, whose subject and content draw not only on poeticized observations of the source material, but also on metapoetic tales about its creators.
‘On account of famine, the internment camp has been dissolved, and the countess is starving at home…’. Letters of Vladimir and Elena Nedzelsky to Vera Bunin from the years 1922–1924
Authors: Yarmolinets V. A.
Published: November 2019

The Nedzelsky are telling Vera Bunina about Viktor, the son of their mutual friend, the writer A. Fyodorov: how he has just turned up in Kishinev, having escaped from the ‘red’ Odessa. The letters from Leeds Russian Archive offer an insight into Viktor’s life in Romania, as well as clues to decipher V. Kataev’s story Werther Has Already Been Written [Uzhe napisan Verter], inspired by the Fyodorovs’ tragic family history. Another theme is related to V. Nedzelsky’s confession of his secret passion for another woman and his desperate efforts to negotiate humanitarian aid (a Hoover food parcel) to save his starving beloved from death. This information can substantially enrich the biographies of the two remarkable Russian female scientists.
S. A. Shargunov. Kataev. In pursuit of eternal spring
Authors: Sekretov S. V.
Published: November 2019

The review of S. Shargunov’s Kataev. In Pursuit of Eternal Spring [Kataev. V pogone za vechnoy vesnoy], opens with a description of the book’s history and structure. The reviewer specifies the biographer’s take on its hero and traces their spiritual and creative similarities in an attempt to explain why S. Shargunov chooses to depict V. Kataev as a ‘first-rate’ and unjustly forgotten writer. The review also takes a look at the biographer’s style and assessment of the turning points in Kataev’s life and legacy. The book covers the writer’s role in the development of the Odessa school of writing in the 1910s–1920s, the young writers’ group centered around Kataev-managed journal Yunost in the 1960s, and the novel My Diamond Crown [Almazniy moy venets], which, published in 1978, provoked a serious debate. In the conclusion, author enumerates the discoveries made by the biographer, and notes the researcher’s interest in history perceived through people.
‘Not a good time for positive heroes’
Authors: Senchin R. V. , Konstantinova E. I.
Published: November 2019

E. Konstantinova interviews R. Senchin, a writer, journalist, shortlisted entry and winner of numerous literary prizes: Russian Booker (2009), National Bestseller (2010), The Culture Prize of the Russian Government (2012), Yasnaya Polyana (2014), The Big Book [Bolshaya Kniga] (2015), and others. They discuss Senchin’s personal creative experiments and discoveries as well as contemporary Russian prose in general. Senchin opines that modern literature, having digested the experiences of the ‘new realism’ of the 1990s–2000s, has moved on to discover writers’ individual characteristics and harness new subjects, including documentary ones. Given the limitations of the forms and methods of artistic literature, Senchin argues, an unexpected choice of topic, language, intonation or plot comes to the forefront. However, he prefers to stick to recognizable, traditional subjects and recurrent characters. The exploration of the motivations and personality of those characters (the writer Savateev and the office clerk Chashchin) takes up most of the interview.
A Review of Photodynamic Therapy with Enhancement for the Treatment of Actinic Keratosis
Authors: Marcus Linda Susan
Published: November 2019

Actinic keratosis are the earliest lesions in the continuum of the development of squamous cell carcinomas and, therefore, should be treated. Although they may appear as unique lesions, field canalization is the norm. Various modalities are used periodically throughout a patient's lifetime. In an effort to address better and longer clearances, combination sequential therapies including topical and mechanical treatments either prior or post photodynamic therapy have been tried. Treatment protocols should be tailored to an individual patient as a specific point of time to achieve the best results. There are a few case and anecdotal reports, however, there have not been controlled clinical evaluations. This is a review of possible algorithms that are used, but definitive studies should be done.
Efficacy of a single fixed 131I dose of radioactive iodine for the treatment of hyperthyroidism
Authors: Radhi Husain
Published: November 2019

A total of 135 patients were treated for hyperthyroidism with 131I 15 mCi radioiodine ablation. The therapeutic target was achieving hypothyroidism. Between January 2014 and December 2018, clinical records were reviewed and date was collected and reviewed for 135 patients with hyperthyroidism that were referred to the Nuclear Medicine Department at Salmaniya Medical Center, for radioactive iodine (RAI) thyroid gland ablation procedure for definitive treatment of hyperthyroidism. About 39.7% of our patients achieved response between 4-6 months out of which 35.7% of the patients showed response in the first 3 months. 21.4% of the patients took between 7-12 months to show response and only 3.2% responded after 12 months. The most significant response was hypothyroidism comprising of 94.4%. It is also worth mentioning that 4.0% of patients achieved euthyroidism and did not require any follow-up medication. Using fixed dose of RAI of 15mCi for treating various type of Hyperthyroidism, successful treatment with a single dose of RAI can be achieved in 92.7% of the patients, with first therapy failure rate in 7.3%, with few patients requiring additional doses of RAI.
Effects of Experimental Hyperthyroidism on Collagen IV and Laminin-α5 Gene Expression in Balb/C Mouse Seminiferous Tubules
Authors: Sadeghi Saeed , Jalali Mahdi , Nikravesh Mohammad Reza , Sankian Mojtaba
Published: November 2019

Background: Hyperthyroidism is one of the disorders of the thyroid gland, an organ that controls the cellular and molecular behaviors of the seminiferous tubule basement membrane (BM), and ultimately, influences its evolutionary process. We aimed to investigate the effects of hyperthyroidism on immunohistochemical characteristics and gene expression levels of collagen IV and laminin-α5 in seminiferous tubules BM of Balb/C mice. Materials and Methods: Twenty male Balb/C mice were divided into experimental and control groups. The experimental group received 500 mg/l of levothyroxine (L-thyroxine) diluted in drinking water for two months to inducing hyperthyroidism, which was confirmed by radioimmunoassay. At the end of the study, the mice were sacrificed, and their testes were extracted for immunohistochemistry and real-time polymerase chain reaction assays. Results: Although a weak reaction was observed in the experimental specimens, no significant enhancement was noted in color intensity of type IV collagen in the seminiferous tubules BM of the experimental group as compared to the control group (P>0.05). Collagen IV gene expression results in the experimental group were not significantly different from the controls (P>0.05). Thus, there was a significant increase in laminin α5 gene expression compared to the control group (P=0.016). Conclusion: Considering the key role of collagen IV and laminin-α5 in the seminiferous tubule BM in the testes, the results of this study indicated that hyperthyroidism has important effects on both structures and functions of these two components. [GMJ.2019;8:e1369]
COMPARATIVE-AGE CHARACTERISTICS OF THE STATE OF THE NEUROVEGATIVE REGULATION OF THE GASTROINTESTINAL TRACT IN INTENSIVE CARE PATIENTS
Authors: Shkrupii D. , Mogylnyk A. , Sonnik E.
Published: November 2019

Introduction. The autonomic nervous system is considered to be the leading adapter of the body to changing conditions of existence The intestine is subjected to massive irritating effects, and therefore is actively regulated by the autonomic nervous system, and itself, at the same time, is its regulator. In intensive care conditions, autonomic reactions change under the influence of critical state inducers. The purpose of the study: a comparative analysis of the neurovegetative regulation of the gastrointestinal tract in patients under intensive care in an age-related aspect. Materials and methods. Under observation were 70 patients in need of intensive care. Of these, 30 are children of the first month of life and 40 are adult patients. The study applied methods of cardiointervalography and assessment of the degree of gastrointestinal failure syndrome. The results of the study. The analysis of cardiointervalograms showed a relatively equal tension of the sympathetic part of the autonomic nervous system, regardless of age. However, in children, in comparison with adults, a more pronounced relative dysbalance of autonomic regulation in favor of humoral sympathetic influences is noted, which significantly increases the stress index in childhood. Despite the pronounced activity of the humoral channel for regulating autonomic homeostasis, it was not a factor affecting the severity of gastrointestinal failure syndrome. Therefore, this factor may be trigger in the formation of intestinal dysfunction, but not determining in the formation of its severity. Correlation in the adult group indicates the predominance of parasympathetic influences in the formation of gastrointestinal failure syndrome. Among children, unlike adults, the formation of this syndrome is associated not only with changes in the parasympathetic department, but with hypersympaticotonia. Conclusions. Regardless of the age, in patients with intensive care, an increase in tension of the sympathetic part of the autonomic nervous system is noted. In children, compared with adults, a markedly pronounced activity of humoral sympathetic influences was noted. At the same time, parasympathetic activity is the decisive factor in the progression of gastrointestinal failure syndrome in adults, and hypersympathicotonia in children.
MORPHOLOGICAL ANALYSIS OF THE COMBINED BREAST AND OVARIAN CANCER
Authors: Babenko V.I. , Sidorenko M.I. , Filenko B.М. , Royko N.V. , Novoseltseva T.V.
Published: November 2019

Breast cancer, as a hormone-dependent malignancy, has a high risk to trigger synchronous or metachronous ovarian tumor. Studying the biological characteristics of tumors to determine the most adequate prognosis and to select the best treatment is extremely relevant. The purpose of the paper was to investigate the histological and immunohistochemical features of combined breast and ovarian cancer in women. A retrospective analysis of the past medical histories of women with combined breast and ovarian cancer, regardless the sequence of their occurrence that involved the study of histological and immunohistochemical characteristics of the tumors, has been carried out. The average age of women at the time the tumors were detected on both localizations was 59.5 ± 10.3 years. The primary tumor appeared in either the breast or the ovaries at about the same incidence. In one case, tumors of both localizations were diagnosed at the same time when the patient sought for medical assistance. The average time period between the development of breast and ovarian cancer was 3.3 ± 2.8 years. Histologically, 93.3% of breast cancers are invasive ductal carcinoma, moderately differentiated (7 cases), poorly differentiated (6 cases), and well differentiated (2 cases). Ovarian cancer is histologically represented by poorly differentiated adenocarcinoma (10 cases), moderately differentiated variant (3 cases) and well differentiated variant (2 cases). Immunohistochemically, the tumors on both localizations were characterized by the similar expression of the investigated markers. The findings of the study confirm that the women have a certain morphological and immunohistochemical pattern of the tumor process in the breast and ovary. It can be assumed that the tumors of the above localizations are interrelated processes, which are likely to be hereditary.
EFFECT OF MODULATORS OF REDOX-SENSITIVE TRANSCRIPTIONAL TRANSCRIPTION FACTORS ON MORPHOLOGICAL CHANGES IN PERIODONTIUM OF RATS DURING SYSTEM INFLAMMATORY RESPONSE
Authors: Yelins’ka A.M. , Starchenko I.I. , Kostenko V.O.
Published: November 2019

The experiment carried out on 30 white rats was aimed at studying pathomorphological changes in periodontal tissues during lipopolysaccharide-induced systemic inflammatory response and their nature when a water-soluble form of quercetin and epigallocatechin-3-gallate was administered to the animals. The rats were divided into 4 groups: the 1st group included animals after systemic administration of S. typhi lipopolysaccharide (pyrogenal); the 2nd and 3rd group involved animals, which were injected with a water-soluble form of quercetin (10 mg/kg) and epigallocatechin-3-gallate (21.1 mg/kg) intraperitoneally (every 3 days) starting from the 30th day of the experiment. Pyrogenal was administered in a dose of 0.4 μg/kg 3 times during the 1st week and once a week for the next 7 weeks. Sections of 4–6 μm thick were cut from paraffin blocks and stained with hematoxylin and eosin. It has been found out that experimental modeling of a systemic inflammatory response leads to the development of morphological signs of periodontitis, which are manifested by inflammation and destruction of periodontal pockets, the formation of pathological periodontal pockets, destructive changes in bone tissues of the alveolar process and in the cementum of the dental root. The use of the water-soluble form of quercetin and epigallocatechin-3-gallate in the experimental conditions changes the morphological picture of inflammatory and destructive processes in the periodontium: it prevents the formation of purulent exudate, reduces the intensity of the resorption of cementum and bone tissue of the alveolar process, accelerates the development and maturation of granulation tissue in the walls of periodontium, promotes the replacement of bone defects with connective tissue, and enhances the regeneration of cementum.
MICROSCOPIC STRUCTURE AND MORPHOMETRIC PARAMETRES OF LONG TUBULAR BONES OF SENILE RATS WITH INDUCED HYPERGLYCEMIA
Authors: Ponyrko A.A.
Published: November 2019

Recent studies have shown that patients with diabetes mellitus are found very often to have pathological changes in the musculoskeletal system. Discussing the development of pathological changes in the bone tissue due to hyperglycemia, it should be noted that many aspects of this problem are still unexplained, and in particular the frequency of bone damage varying in a fairly wide range, the mechanism of reducing bone mineral density that leads to the occurrence of frequent fractures. This article discusses the effects of hyperglycemia on the state of long tubular bones. The goal of our experiment was to study the structural changes in the long tubular bones of senile rats of both sexes with induced hyperglycemia. The period the rats were included into the experiment ranged from 30 to 180 days. During the experiment, various research methods were applied. To perform the histological analysis, we took rat femurs and fixed them in 10% phosphate buffered formalin for 24 hours. Then samples were decalcified in 10% formic acid solution, the materials obtained were embedded in paraffin. The study revealed a gradual thinning of the cortical layer in senile rats that is of great importance due to the fact that there is clinically confirmed increased risk of femoral neck fracture in individuals with type II diabetes. The level of blood glucose throughout the experiment was rather high that indicates the development of chronic hyperglycemia. Having analyzed the data on the effect of hyperglycemia on bone growth parameters and comparing these indicators with the control, we can suggest a delay in longitudinal growth of bones. The results and timing of the experiment show that the degree of changes obtained depends on the duration of the experiment.
CLINICAL AND EPIDEMIOLOGICAL CHARACTERISTICS OF PATIENTS WITH HIV INFECTION
Authors: Andrushchak M.O. , Moskaliuk V.D. , Balaniuk I.V. , Rudan I.V.
Published: November 2019

According to the latest data, in early 2018, 75% of HIV-positive people in the world knew about their HIV status (70% in early 2017); 79% of those who knew about their HIV status received treatment, 81% of those who received antiretroviral therapy have achieved an undetectable level of HIV viral load in the blood, i.e. less than 1000 RNA copies / ml. The purpose of the work is to find out the current clinical and epidemiological features of HIV infection, including in the Bukovina region. Materials and Methods: this prospective study for 2016 – 2018 included 292 HIV patients undergoing outpatient monitoring at the Chernivtsi Regional Center for AIDS Prevention and Control. All the subjects gave voluntary informed consent to participate in the study. Results and Discussion: Young people (25 – 44 years old) were predominantly included in the study; their total share among men was 88.3% and among women – 76.0%. There were slightly more female patients under 24 years of age (10.6% of female individuals versus 4.3% of male individuals) and within the 45-55 year old group (13.4% female participants versus 7.4% of male individuals). Clinical signs of stage III HIV infection found in 108 people included the manifestations of general intoxication syndrome forcing the participants to stay down in the bed up to a half a day. All the participants demonstrated the weight loss over 10% of that initially established; 34 (31.5%) patients had "unexplained" chronic diarrhoea over 3 times a day, which lasted more than a month. For 118 HIV-positive patients of the IV clinical stage, the fatigue syndrome (unexplained weight loss (more than 10% for 6 months) was the most indicative; this condition forced them to stay in bed for more than a half a day. Conclusions: Markers of hemocontact viral hepatitis were detected in 59.1% of patients with clinical stage I and II HIV infection, in 55.6% of the patients with III stage HIV and in 61.0% with stage IV of the disease.
PREDICTORS OF HIV INFECTION PROGRESSION BEFORE PRESCRIPTION AND ON ART
Authors: Marchenko O. , Koval T. , Sizova L. , Pryimenko N.
Published: November 2019

The search for predictors of the progression of HIV infection to the clinical stage IV in patients before prescription and on antiretroviral therapy (ART) is an urgent scientific and practical task. The study aimed to identify predictors of the progression of HIV infection to the clinical stage IV in patients before prescribing and on the background ART based on the determination of clinical and genetic markers. A retrospective cohort study of 181 HIV-infected patients was conducted. For statistical data processing, regression analysis was used. Independent predictors of the progression of HIV infection to clinical stage IV in HIV-infected patients prior to ART were: male (p = 0,037), parenteral HIV transmission (p = 0,004), conclusion experience (p = 0,020), body mass index (BMI) less than 18.5 kg / m2 (p = 0,040), initial viral load (HV) of HIV> 1.0 x 105 copies / ml (p = 0,034), initial level of CD4 + T-lymphocytes <350 cells / μl (p = 0,000), hemoglobin level below 100 g/l (p = 0,001), the presence of which increases the risk of HIV progression to the clinical stage IV prior to prescribing ART. Independent predictors of the progression of HIV infection to the clinical stage IV in HIV-infected patients receiving ART were: parenteral transmission of HIV infection (p = 0,053), previous incarceration (p = 0,043), low adherence to ART (p = 0,028) , the initial level of CD4 + T-lymphocytes <350 cells/μl (p = 0,020), hemoglobin level below 100 g/l (p = 0,015) and carriage of the 299 Gly allele of the TLR4 gene (p = 0,016).
MEDICAL AND SOCIAL ISSUES ON PREVENTING PREMATURE DEATH OF POPULATION IN POLTAVA REGION
Authors: Belikova I.V. , Kostrikov A.V. , Krasko N.M.
Published: November 2019

World Health Organization in its document “Health-21. The Health for All Policy Framework for Health in the WHO European Region” set targets to address the reduction in mortality rates associated with cardiovascular disease in people under 65 by an average 40%. The purpose of this study was to analyze the dynamics of mortality in the population of the Poltava region, to determine the age and sex patterns of mortality from circulatory diseases in the population of Ukraine, to conduct a comparative analysis of the data in order to identify possible ways to improve the situation. The research materials were data from the State Statistics Service of Ukraine and data from the Poltava Regional Information and Analytical Centre for Medical Statistics of the Poltava Regional Council ", the database" Health for All "(HFA-DB) was also used. A retrospective study of the morbidity and mortality rates by age, sex and causes was carried out (2014-2018rr). The study was based on bibliosemantic and information-analytical methods, the statistical method of analyzing time series. The analysis of the demographic situation in the Poltava region indicates a decrease in mortality, but the indicator is still remaining at an extremely high level (16.9 ‰). Diseases of the circulatory system are ranking the leading position among the causes of population mortality. The analysis of the morbidity among the population of the Poltava region indicates an increase of the prevalence and incidence of circulatory diseases among both urban and rural population. Based on the results obtained, we worked out recommendation aimed at reducing morbidity and premature mortality from circulatory diseases through enhancing the awareness of behavioural risk factors. Data on the causes of public health losses and risk factors can help healthcare authorities responsible for public health policy-making and health system financing to set priorities for prevention strategies in order to achieve better public health.
HEMATOLOGICAL INDIXES IN PATIENTS WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE WITH ANEMIA
Authors: Radchenko O.M. , Fedyk O.V. , Guta R.R.
Published: November 2019

A retrospective analysis of 470 patients with chronic obstructive pulmonary disease and anemia was conducted in order to determine hematological indices. 17 markers of inflammation activity, endogenous intoxication, adaptation, nonspecific and immune reactivity were calculated during this analysis. It was established that the course of chronic obstructive pulmonary disease with anemia was accompanied by a more pronounced inflammation syndrome with a significant increase in stab and segmented neutrophilic granulocytes, an acceleration of the erythrocyte sedimentation rate, and significantly higher integral hematological inflammation indixes (leukocyte shift index, indexes of correlation: -leukocytes to erythrocyte sedimentation rate, -neutrophils to erythrocyte sedimentation rate, -nonsegonuclear neutrophils to erythrocyte sedimentation rate, neutrophils to lymphocytes; inflammation activity index, integrated inflammation index), large endogenous intoxication (neutrophil reactive response index, leukocyte intoxication index), change in adaptation, nonspecific reactivity (decrease in adaptation index, immune reactivity and allergization, and increase in the ratio indices: lymphocytes to monocytes, - lymphocytes to eosinophils) with activation of the phagocytic link of nonspecific protection over cell-humoral. The determination of integral hematological indices is an important, informative and accessible method for assessing the general condition of a patient with chronic obstructive pulmonary disease and anemia.
ON IMPROVING THE TREATMENT OF PATIENTS WITH CHRONIC WOUNDS OF VENOUS GENESIS
Authors: Rybalka Ya.V.
Published: November 2019

Introduction. The analysis of the effectiveness of applying autologous platelet-rich plasma was performed in order to improve the results of surgical treatment of patients with wounds that heal slowly. Materials. The study is based on the analysis of the treatment of 61 patients who suffered from slow-healing wounds of venous genesis with a diameter of no more than 8 cm on the lower extremities and took the treatment at the surgical ward. The proposed method was based on obtaining autologous enriched platelet plasma followed by its injection along the periphery of the wound. The degree of reduction of the wound surface area was assessed by the method of contact planimetry per day. The patients of the 1st group demonstrated the wound area reduction by 5.1 ± 0.6%, and the patients of the group 2 – by 1.8 ± 0.4% (p <0005). The results indicate an increase in the rate of wound healing in patients in group 1 compared with patients in group 2. During the entire follow-up period (12 weeks), complete wound epithelialisation occurred in 21 (70%) patients in group 1 and in 10 (33.3%) patients of the group 2. The wound area decreased by more than 50% in 6 patients of group 1 (20%) and in 2 (7%) patients of the control group. The wound area decreased less than by 50% in 3 patients in group 1 (10%), and in 19 patients in group 2 (60%). The use of PRP therapy has been proven to have a significant positive effect on the process of wound healing compared with the use of standard methods used for the control group. Conclusion: increase in the wound healing pace in patients of group 1 (test) compared with patients of group 2 (control) can be explained by using autologous platelet-enriched plasma as an additional means to the standard therapy.
OUR VIEW ON THE ETIOLOGICAL CAUSES OF IRWIN-GASS SYNDROME AFTER CATARACT SURGERY
Authors: Steblovska I.S. , Bezkorovayna I.M. , Voskresenskaya L.K. , Ryadnova V.V. , Pera-Vasylchenko A.V.
Published: November 2019

The transition to small incision surgery and the introduction of this type of surgery in the period from the late 80's to 2005 enabled to reduce the share of postoperative complications, but despite the significant achievements of this surgical approach, some patients have unsatisfactory postoperative results due to the development of retinal macular oedema. Even at the present stage of the development of medical science, there has been no universally recognized theory of the aetiology and pathogenesis of Irwin-Gass syndrome. Despite the numerous reports on the aspects of macular oedema development following cataract phacoemulsification, a number of issues related to the mechanism of its development and predictability are remaining unexplored, and in particular the role of MMA and morphometric indicators in this process. Therefore, the purpose of this study was to analyze the causes of Irvine-Gass syndrome by comparing and evaluating the development of complications in the pre- and postoperative period, CDE, duration of intraocular surgery, the level of intraocular fluid prostanoids, density of corneal endothelial cells and morphofunctional cells. The enzyme-linked immunosorbent assays have demonstrated that among the leading risk factors for macular edema following surgical treatment of cataract patients are the ultrasound power, the duration of surgery, the state of the prostanid system of vision apparatus and their ratio coefficient. The results obtained can contribute to solving a specific scientific problem of ophthalmology, the prediction of macular edema after surgical treatment for patients with age-related cataracts.
ANALYSIS OF CORRELATION BETWEEN BGLAP RS1800247 POLYMORPHISM AND DEVELOPMENT OF TYPE 2 DIABETES MELLITUS IN SMOKERS AND NON-SMOKING INDIVIDUALS
Authors: Chumachenko Ya.D. , Roshchupkin A.A. , Harbuzova V.Yu.
Published: November 2019

It is known that the skeleton tissue performs systemic energy metabolism regulation through the release decarboxylated fracture of osteocalcin. The aim of this study was to analyze the correlation between rs1800247 polymorphic variant of BGLAP gene and the development of type 2 diabetes mellitus in Ukrainian smokers and non-smoking individuals. There was no significant differences in alleles and genotypes distributions in both smoking subgroup (χ2 = 0,062; Р = 0,803 and χ2 = 0,222; Р = 0,895 respectively) and non-smoking (χ2 = 1,382; Р = 0,24 and χ2 = 3,314; Р = 0,191 respectively) groups. Using logistic regression method it was established the lack of association between rs1800247-polymorphic locus of BGLAP and type 2 diabetes mellitus in crude models and after the adjustment for age, sex, mass body index and the presence of arterial hypertension (Р ˃ 0,05). No statistically significant differences were found out between clinical and laboratory values among diabetic patients stratified by genotype in one-way analysis of variance (Р ˃0,05). It suggests the conclusion that rs1800247-polymorphism is not associated with type 2 diabetes mellitus development in both smokers and  non-smoking individuals.
Can biotech crops improve soil health?
Authors: Job Francis Oguta Job
Published: November 2019

The Uganda's most competitive essay challenge focused on biotechnological aspects. In the year 2017, 5th Annual national biotechnology essay contest was organised under the theme; 'can biotech crops improve soil health?' and this very essay was number 8 in the University Category.
Evolution of the main geomorphological structure of the Holocene Kuban river delta
Authors: Svitoch A. A. , Magritskiy D. V. , Porotov A. V. , Makshaev R. R. , Tyunin N. A. , Semikolennykh D. V. , Dikarev V. А. , Kluyvitkina T. S.
Published: November 2019

In the recent epoch the Kuban River delta is characterized by little distributary with low zone of lagoons and flooded areas. This accumulative plain includes different types of mesorelief such as longshore bar, channel bank, liman, plavni and channel distributaries. There are three huge geomorphological types of Kuban delta: old, young deltas and Kuban-Taman region. The main differences between them are diverse geomorphological levels, evolution of marine and fluvial forms and incomplete geomorphological development.

The relief of the Kuban delta is Holocene. The main factors of its formation were large-scale fluctuations of the Azov-Black Sea basin, the flow of water and sediment of the Kuban River and its distribution in area. In the history of the development of the modern relief of the Kuban delta, there are three stages (epochs). The first is the Bugaz stage of the Holocene transgression (9.57.9 ka), when the relief of the old delta was formed. In the second stage of the Holocene transgression (Vityazevskaya, Kalamitskaya, and Dzhemetyan stages), a transitional type of relief was formed in the area adjacent to the floods of the young delta and the old delta with the formation of large buried bars. In the third stage, the systems of modern estuaries and plavni were formed, separated from the sea by a modern coastal bar.
Morphogenetic analysis of erosion topography the right Volga river bank (Volgograd region, Russia)
Authors: Seleznevа A. V. , Dedovа I. S.
Published: November 2019

The article is devoted to a detailed morphogenetic analysis of erosion topography of the right Volga river bank (Volgograd region, Russia). The estimation of the factors in the development of erosion processes: lithological, geomorphological, climatic, biotic. It is established that the general trends of the development and the propagation of gully systems depend on the zonal conditions, and their specificity from structural-lithological and geomorphological features of the area. The actual basis for the work, based on data from field observations, interpretation of satellite imagery, morphometric processing of topographic maps. The obtained results were used for compiling maps, morphometric characteristics of the relief and zoning of the right bank of the Volgograd city according to the intensity of erosion processes. It was established that the studied area is among the most erosion-affected territories in the European part of Russia with the average erosion density of the network from 0.10.3 up to 34 km/km2. Comparison of factors determining the intensity of the evolution and morphology of gully systems led to the conclusion that modern intensification of erosion is the result of economic activities.
Mobile Platform Biometric Cloud Authentication
Authors: Ximenes Agostinho Marques , Sukaridhoto Sritrusta , Sudarsono Amang , Basri Hasan
Published: November 2019

Berdasarkan data Pusat Statistik Indonesia, tingkat kemiskinan pada bulan September 2018 adalah 25,95 juta, berdasrkan data tingkat kemiskinan masyarakatÂ  tersebutÂ  pemeritnah menyalurkan dana bantuan mengatasi tingkat kemiskinan masyarakat melalui Bank. Namun, Bank tidak dapat mengalokasikan dana karena biaya untuk membangun infrastruktur mahal, seperti membuat ATM.Berbagai kendala tersebut, Bank perlu menemukan solusi baru agar dapat mengalokasikan dana kepada masyrakat dengan biaya yang murah, Mobile Platform Biometric Cloud Authentication adalah salah satu solusi. Dalam penelitian ini, eksperimen yang dilakukan melakukan autentikasi dengan QR Code Scan dan face recognize (data face dienkripsi dan didekripsi dengan kritografi algoritma AES 256 bit). Konsentrasi penelitian ini terletak pada Â eksperimen terhadap komunikasi keamanan data transaksi paymentÂ  merchant onlie degan QR Code scan dan Face recognize yang berbasis mobile android dan serta spesfikasi android versi 23. Hasil pengujian pada aplikasi Mobile ini menunjukkan bahwa QR Code scan dan face recognize dapat diimplementasikan pada transaksi payment merchant online dengan akurasi 95% dan membutuhkan 53, 21 detik per transaksi.