bluuebunny/crossref_metadata_2025 huggingface dataset:
Drivers of tipping points in coupled human-environment systems
Authors: Farahbakhsh Isaiah , Bauch Chris T. , Anand Madhur
Published: July 2023

Abstract. Mathematical models that couple human behaviour to environmental processes can offer valuable insights into how human behaviour affects various types of ecological, climate and epidemiological systems. In many coupled systems, gradual changes to the human system can lead to abrupt tipping points in the overall system, leading to desirable or undesirable new human-environment states. We review aspects of human behaviour–such as social norms and rates of social change–that drive tipping points in the modelling literature, finding that many affect the coupled system depending on the system type and initial conditions. Structural components in the human system, often represented through social networks, are discussed with many studies showing high structural complexity increases the potential for tipping points. Traditional and state-of-the-art techniques in early warning signals are introduced in relation to the human drivers discussed in previous sections. We conclude with an outline of challenges and promising future directions specific to furthering our understanding and informing policy interventions around promoting sustainability within coupled human-environment systems.
A Synthesis of Global Streamflow characteristics, Hydrometeorology, and catchment Attributes (GSHA) for Large Sample River-Centric Studies
Authors: Yin Ziyun , Lin Peirong , Riggs Ryan , Allen George H. , Lei Xiangyong , Zheng Ziyan , Cai Siyu
Published: July 2023

Abstract. Our understanding and predictive capability of streamflow processes largely rely on high-quality datasets that depict a river’s upstream basin characteristics. Recent proliferation of large sample hydrology (LSH) datasets has promoted model parameter estimation and data-driven analyses of the hydrological processes worldwide, yet existing LSH is still insufficient in terms of sample coverage, uncertainty estimates, and dynamic descriptions of anthropogenic activities. To bridge the gap, we contribute the Synthesis of Global Streamflow characteristics, Hydrometeorology, and catchment Attributes (GSHA) to complement existing LSH datasets, which covers 21,568 watersheds from 13 agencies for as long as 43 years based on discharge observations scraped from web. In addition to annual streamflow indices, each basin’s daily meteorological variables (i.e., precipitation, 2 m air temperature, longwave/shortwave radiation, wind speed, actual and potential evapotranspiration), daily-weekly water storage terms (i.e., snow water equivalence, soil moisture, groundwater percentage), and yearly dynamic descriptors of the land surface characteristics (i.e., urban/cropland/forest fractions, leaf area index, reservoir storage and degree of regulation) are also provided by combining openly available remote sensing and reanalysis datasets. The uncertainties of all meteorological variables are estimated with independent data sources. Our analyses revealed the following insights: (i) the meteorological data uncertainties vary across variables and geographical regions, and the prominent patterns revealed should be accounted for by LSH users, (ii) ~6 % watersheds shifted between human managed and natural states during the GSHA time span, which may be useful for hydrologic analysis that takes the changing land surface characteristics into account, and (iii) GSHA watersheds observed a more widespread declining trend in runoff coefficient than an increasing trend, which warrants further studies on water availability. Overall, GSHA is expected to serve hydrological model parameter estimation and data-driven analyses as it continues to improve. GSHA v1.0 can be accessed at https://doi.org/10.5281/zenodo.8090704 (Yin et al., 2023).
A decade of systematic reviews: an assessment of Weill Cornell Medicine's systematic review service
Authors: Demetres Michelle R. , Wright Drew N. , Hickner Andy , Jedlicka Caroline , Delgado Diana
Published: July 2023

Background: The Weill Cornell Medicine, Samuel J. Wood Library’s Systematic Review (SR) service began in 2011, with 2021 marking a decade of service. This paper will describe how the service policies have grown and will break down our service quantitatively over the past 11 years to examine SR timelines and trends.
Case Presentation: We evaluated 11 years (2011-2021) of SR request data from our in-house documentation. In the years assessed, there have been 319 SR requests from 20 clinical departments, leading to 101 publications with at least one librarian collaborator listed as co-author. The average review took 642 days to publication, with the longest at 1408 days, and the shortest at 94 days. On average, librarians spent 14.7 hours in total on each review. SR projects were most likely to be abandoned at the title/abstract screening phase. Several policies have been put into place over the years in order to accommodate workflows and demand for our service.
Discussion: The SR service has seen several changes since its inception in 2011. Based on the findings and emerging trends discussed here, our service will inevitably evolve further to adapt to these changes, such as machine learning-assisted technology.
More than just pronouns – gender-neutral and inclusive language in patient education materials: suggestions for patient education librarians
Authors: Philippopoulos Eleni
Published: July 2023

Trusted patient education materials are the backbone of an effective consumer health library. However, members of the LGBTQ+ community may not see themselves or their families reflected in many resources due to the gendered and non-inclusive language they are written in. This article outlines some suggestions for concrete actions that patient librarians can take to ensure that their materials are not excluding LGBTQ+ patients.
RESEARCH OF THE STRUCTURAL-PHASE STATE OF TUNGSTEN SURFACE LAYER CROSS-SECTION AFTER CARBIDIZATION IN A BEAM-PLASMA DISCHARGE USAGE ELECTRON MICROSCOPY METHODS
Authors: Skakov M. K. , Baklanov V. V. , Zhanbolatova G. K. , Miniyazov A. Zh. , Kozhakhmetov Ye. A. , Gradoboev A. V.
Published: July 2023

This paper presents research results on the structural-phase state of a tungsten surface layer cross-section after carbidization in a beam-plasma discharge. Tungsten surface carbidization in a beam-plasma discharge was conducted in a plasma-beam installation (PBI). Research on the cross-section structure of the surface layer of tungsten samples after carbidization at temperatures of 1000 °C, 1200 °C, and 1400 °C was conducted using transmission and scanning electron microscopy. Based on the results of SEM studies, a multilayer EMF map and local elemental analysis were obtained, based on which the depth of penetration of carbon atoms into tungsten was evaluated. It is established that the penetration depth is ~20 µm. The surface layer fine structure was researched using TEM. For TEM analysis of the tungsten sample cross-section with a carbidized layer, sections were prepared by ion thinning using an Ion Slicer EM-09100 IS unit. According to the research results, it was revealed that after carbidization, tungsten is available in the surface layer mainly in the composition of carbides WC and W2C. On bright-field TEM images of the cross-section of the surface layer of tungsten samples after carbidization at a temperature of 1200 °C and 1400 °C, bending extinction contours are revealed, which indicate the elastically stressed state of the sample surface layer, which leads to bending-torsion of the foil.
Antibacterial and Wound Healing Activity of Ethanolic Extract Melastoma malabathricum L
Authors: Isnaini Isnaini , Oktaviyanti IkaKustiyah , Budiarti Lia Y.
Published: July 2023

Melastoma malabathricum L are plants that are widely found in South Kalimantan. This plant grows along the riverbanks. Flowers of M. malabathricum L have antibacterial activity greater than leaves in Staphylococcus aureus bacteria. Every fase of M. malabathricum L flowers contents different quercetin and kaempferol. M. malabathricum L flower phase consists of bud phase 1 (K1), bud phase 2 (K2), bud phase 3 (K3) and blooming phase (M). Quercetin and kaempferol are also found in M. malabathricum L fruit (F). The highest content of quercetin and kaempferol is in the blooming phase. Quercetin and kaempferol have antibacterial and wound healing activity. This research aims to analyze the antibacterial and wound healing activity of ethanolic extracts of M. malabathricum L flower (FL) and fruit (FR). The method antibacterial activity is used the liquid dilution method and continued with planting on agar media. The wound healing activity was tested on rat that were smeared with cream for 14 days and examined the histopathology of the skin. Concentration of extract is 1%, 2% dan 4%. The results showed that the skin smeared with FLC (flower cream) 4% had formed adnesia, while the other treatments had not yet formed.
Derivative Spectroscopic Method and RP-HPLC Method Development and Validation of Levofloxacin hemihydrate
Authors: Sen Sandip , Ravindar Bairam , Jala Sirikonda , Dharabonia Laxmi , Rajeshwari Konika
Published: July 2023

The present work describes the development of a simple, precise and accurate derivative spectroscopic and RP-HPLC method for the estimation of levofloxacin hemihydrate in the tablet dosage form. Levofloxacin hemihydrate showed absorption maxima at 287.36, 287.2 and 296.2nm in zero, first and second-order spectroscopic methods. The RP-HPLC method was optimized by using Orthophosphoric acid: acetonitrile: methanol (50: 20: 30) as solvent at 287nm. The methods showed linearity in the concentration range 1-5 and 2-10 µg/ ml and the correlation coefficient was 0.999 respectively. The method has been validated according to the ICH guidelines. The percentage relative standard deviation was found to be less than 2% in respect of both methods.
Formulation and Evaluation of Floating Microspheres of Sitagliptin
Authors: Rao A. Anka , Malothu Narender. , Rao A. Narayana , Naga Raju Bandaru , Mohammed B. Jahasultana.
Published: July 2023

Gastro retentive dosage forms have potential for use as controlled- release drug delivery systems. Gastro retentive floating drug delivery systems have a bulk density lower than that of gastric fluids and thus increase residence time of drug in stomach and provide controlled delivery of many drugs. The aim of the present study is formulation and characterization of floating microspheres using Sitagliptin as a model drug for the management of type-2 diabetes mellitus. Floating microspheres were prepared by oil-in-water emulsion solvent evaporation technique using ethyl cellulose and eudragit S-100 as release retarding polymers. The floating microspheres were evaluated for percentage yield (%), particle size, drug content, drug entrapment efficiency, in-vitro floating ability and in-vitro drug release studies. The surface morphology of prepared microspheres was characterized by scanning electron microscopy. The microspheres were found to be spherical in shape and porous in nature. Compatibility studies were performed by fourier transform infrared (FTIR) technique. The prepared microspheres showed prolonged drug release of 12 h and remain buoyant for more than 12 h. In-vitro release kinetics were studied in different release kinetics models like zero order, first order, higuchi and korsmeyer peppas model and the best fit model was found to be higuchi plot with release exponent n value less than 0.89. It was concluded that developed floating microspheres of Sitagliptin offers a suitable and practical approach for prolonged release of drug over an extended period of time and thus oral bioavailability, efficacy and patient compliance is improved.
Exploring the Concept of Learning Management Apparatus Utilizing Deleuze’s Dispositif Theory: Focusing on the Line of Subjectivation
Authors:   The Korean Society for Lifelong Education, Lee Kyunglim , Kim Euitae
Published: July 2023

Learning Management Apparatus (LMA) is a concept that explains the mechanism of conditioning learners (Kang et al., 2017). While research on LMA has been accumulating, discussions concerning its theoretical aspects are still ongoing. This article complements the concept of LMA, drawing upon Deleuze's dispositif theory. In the field of social science, the concept of dispositif explains the mechanisms that mediate ideology, power, and governmentality to (re)produce subjects. Educational research has demonstrated the role of dispositif in subjectivation, emphasizing how educational practices function as a dispositif that subjects learners to power and (re)produces them. However, Deleuze's dispositif theory indicates that the line of subjectivation within a dispositif is not completely predetermined, suggesting an incomplete process of conditioning. By adopting Deleuze's dispositif theory, LMA can be understood as a mechanism that conditions learners while also allowing for the emergence of new subjectivities. The contradictory nature of conditioning as (re)production and the emergence of new subjectivities inherent in LMA becomes a fundamental driving force that influences its maintenance, transformation, creation, or dissolution. This article, which explains the conditioning and incompleteness of LMA through Deleuze's dispositif theory, provides a perspective to examine learner transformation in terms of learner (re)production and directs attention to the micro and macro dimensions of education and learning.
The Potential for Theorizing Collective Learning and Key Issues
Authors:   The Korean Society for Lifelong Education, Kim Da Seul
Published: July 2023

As research on collective-level learning has continued to grow in recent years, its significance has become more prominent, necessitating the presentation of a more comprehensive theoretical framework to explicate this form of learning. This study focuses on the potential theorization of collective learning as a comprehensive learning theory that encompasses learning at the collective level. Collective learning frequently lacks precise definitions of concepts and terms, leading to theoretical ambiguity and potential distortions in discussions. To address this, discussions were held to define key concepts such as 'collective' and 'context'. Additionally, considering the strong contextual nature of collective learning, three typologies of collective learning approaches were identified. This served as a foundation to bridge the gaps in discussions and provide reference points for theorization, ultimately yielding the derivation of the concepts and characteristics of collective learning. Subsequently, theoretical controversies pertaining to collective learning were presented to advance discussions and draw out tasks and implications. Key issues in collective learning research, including the question of agency, the possibility of theorizing collective learning processes and methodologies, and the conditions that trigger or influence collective learning, were deliberated upon in addition to the presentation of tasks that need to be addressed through further research. This study on the theorization of collective learning not only contributes to the expansion of lifelong learning research concerning diverse groups but also serves as a learning theory that investigates groups in contemporary society, where collective discussions and actions are increasingly demanded. Thus, It has the potential to offer educational strategies and recommendations.
Oriental thoughts on peace and tolerance
Authors:   Alisher Navo'i Tashkent State university of Uzbek language and literature, Sirojiddinov Shuhrat
Published: July 2023

This treatise describes Central Asians and figures who worked in Central Asia, left a mark in history with their works, services, and creativity, and gained fame in the world for their great contributions to the development of culture.
Stroke profile in patients with high risk of obstructive sleep apnea: a transversal study
Authors: Novais Aurea Maria Lago , Rogério Beatriz Santos , Branco Renan Carvalho Castello
Published: July 2023

Introduction: Obstructive sleep apnea (OSA) is a disease of upper airways, diagnosed with polisomnography, that is well associated with stroke throught diverse mechanisms. Despite that, it still lacks studies about stroke profile in patients with high risk of OSA. Objectives: This study aims to describe the diferences between stroke in patients with high and low risk of OSA. Methods: We performed a transversal study, part of a cohort of stroke patients. Patients were evaluated of risk of OSA with STOP-Bang and SOS scores; also, data of wake-up stroke, stroke type and etiology, transient ischemic attack (TIA), thrombolysis, circulation evolved, ASPECTS (Alberta stroke program early computed tomography score), PC-ASPECTS (posterior circulation - acute stroke prognosis early computed tomography score), hemorragic transformation and its type (ECASS), ABCD2, National Institute of Health Stroke Scale (NIHSS) and death during internment were colectted. Results: We obtained 190 patients. 62.1% were classified as high risk with STOP-Bang and (mean NIHSS 6.59 ± 5.13) and 8.5% died: 5.9% had a TIA (mean ABDC2 5.14 ± 1.21), 22% a wake-up stroke and 81.4% had a ischemic stroke (24 patients were cardioembolic, 34 atherotrombotic and 26 indeterminate), of which 12.7% were thrombolysed and 15.3% had hemorragic transformation. In ´patients with low risk, 2.8% died and we had mean NIHSS 7.64 ± 5.55, 18.3% had wake up stroke and 8.5% a TIA (mean ABCD2 4.17 ± 1.60), 74.6% were ischemic strokes (24% cardioembolic, 23 indeterminated); 12.7% patients were thrombolysed and 21% evolved with hemorragic transformation. Conclusion: We verified a lower NIHSS mean and a higher rate of wake-up stroke, hemorragic transformation and TIA in patients with low risk of OSA. Althought this would suggest better outcomes in population with high risk, they had 5% more deaths: so, despite the aparent better initial state (that we can hypothesize about a type of “lucid interval” in this group), they still evolve worst.
Constructing a low-cost lumbar puncture simulator for medical education
Authors: Alves Rebeca Mamede da Silva , Ferraz Beatriz Gonçalves , Lourenço Gabriela Montanheiro , Simão Luiza Ruiz , Favoretto Amanda , Medola Fausto Orsi , Mazzo Alessandra , Fernandes Adriano Yacubian , Shinohara André Luis
Published: July 2023

Introduction: Simulation has progressively been recognized as a reliable teaching method for delicate medical procedures, including lumbar punctures, an important diagnostic and therapeutic tool. Despite its importance, studies show training to be insufficient, with medical students and residents feeling technically unprepared. Furthermore, multiple challenges lie ahead of implementing curricular training, including costs of simulators, available for prices ranging from US$ 1158,89 to US$ 2.897,21 a unit. Because the technique does not require complex events, selecting a type of simulator can be compatible with simpler but realistic devices that can be made at teaching institutions, not requiring third party suppliers. Objectives: To construct a low-cost lumbar puncture simulator for medical education. Methods: Based on literature and professional experience, critical points of construction and resources available on the market were assessed. A prototype was confectioned with processed vertebrae, sponges, a latex tube filled with water, attached to a syringe for pressure, and makeshift skin and soft tissue from a commercial suture kit, all mounted on a metal apparatus. Results: The simulator concocted of the most cost-effective materials and only the most crucial components performed comparably to brand models according to pre-tests by selected students and experienced professionals. Currently, a more reproductible prototype is being constructed out of 3Dprinted materials, which will be further evaluated and validated. Conclusion: The rough prototype performs comparably to commercial models, and we believe the study will further corroborate modern tendencies to transform teaching into cost-effective techniques that enrich medical education in resource-limited settings.
A Creutzfeldt-Jakob disease mimics: case report
Authors: Gouvêa Sabrina Vechini , Correa Victor Guimarães , Ribeiro Giovana Barros e Silva , Helmer Rafael Saliba , Souza Raíssa Gomes Castro e , Lopes Izadora Vieira Bolzani , Cendes Fernando , Balthazar Marcio Luiz Figueiredo
Published: July 2023

Introduction: Creutzfeld-Jakob Disease (CJD) is an important differential diagnoses in patients with rapidly progressive dementia (RPD). Several inflammatory, immune-mediated, vascular, granulomatous and neurodegenerative conditions can mimic this disease. Objectives: Report a curious case of CJD mimics that was a limbic encephalitis. Methods: A 71-year-old man, with diabetes mellitus. His initial symptoms included visual hallucinations and temporo-spatial disorientation. Over the course of a month, he lost his critical judgment, and began with aggressive behavior and disinhibition. He progressed with gait apraxia and diffuse myoclonic jerks, as well as loss of both bladder and bowel sphincter incontinence and dysphagia. Blood tests results were normal. Cerebrospinal fluid presented increase in proteins (82) without any further alterations. Brain magnetic resonance imaging showed a bilateral increase in T2/FLAIR (T2- weighted-Fluid-Attenuated Inversion Recovery) signal intensity from the hippocampus to the amygdala. Also presented alterations in white matter suggesting microangiopathy (Fazekas 2). Brain PET-CT (Positron Emission Tomography-Computed Tomography) scan showed hypermetabolism in bilateral basal ganglia and mesial temporal regions. EEG evidenced moderate to severe disorganization of background activity and myoclonic jerks with no electroencephalographic correlation. Detection of 14-3-3 protein in cerebrospinal fluid was negative. Results: Patient received 1 g of methylprednisolone for five days and presented significant improvement of clinic symptoms, stopping myoclonic jerks and dysphagia with better tenacity, self-orientation and improved gait. However, he presented persistently short term memory alteration with signs of disinhibition (hyperphagia) that didn`t get better with a second immunotherapy treatment with cyclophosphamide. Conclusion: immune-mediated conditions as encephalitis must be kept in mind when assessing differential diagnoses of RPD and treated as soon as possible
“Wake-up” onset of pharyngocervicobrachial variant of Guillain-Barré syndrome: a case report
Authors: Silva Evelliny Gomes , Holanda Arthur Cesário de , Arca Vitor Maia , Oliveira Daniel Alves , Covaleski Anna Paula Paranhos Miranda , Monteiro Letícia Klabinske Marques , Melo Eduardo Sousa de
Published: July 2023

Guillain-Barré syndrome (GBS) is the most common cause of acute flaccid paralysis in the world. There are variants. Of the cranial forms, the following stand out: the classic form, facial diplegia with distal paresthesias, pharyngo-cervico-brachial form, polyneuritis cranialis, Miller-Fisher syndrome and Bickerstaff encephalitis. This study aimed to report the case of a 73-year-old male patient, diabetic, former smoker and alcoholic, who presented at the Neurology outpatient clinic of a tertiary hospital in Pernambuco, after emergency care and 19 days of symptoms, reported as sudden cervical weakness, dysarthrophonia, dysphagia and weakness in the right hemiface, three weeks after vaccination (influenza and triple viral) and flu syndrome. He had dyspnea since the onset of the condition, with no progression or fluctuating complaints. The neurological examination showed multiple cranial nerve syndrome (right peripheral pattern facial palsy, reduced elevation of the soft palate and cervical extension paresis) associated with global hypo/arreflexia. Complementary exams showed, in addition to leukocytosis and signs of bronchopathy on chest tomography, cerebrospinal fluid with 00 cells and 48 proteins and electroneuromyography with predominantly sensitive axonal polyneuropathy, decrease in bilateral facial motor amplitude, needle with myopathic pattern. Brain magnetic resonance imaging without alterations. With the possibility of cranial polyradiculoneuritis and a history of dyspnea raised, he was admitted to the intensive care unit to monitor his breathing pattern and dysautonomia. He received antibiotic therapy for seven days due to pneumonia and pulse therapy with IVIG (2 g/kg for five days). He maintained progressive improvement of symptoms. He was discharged with a multidisciplinary outpatient follow-up scheduled. It is concluded, therefore, that the recognition of GBS and variant forms is necessary.
Patient-reported outcome measures with multiple sclerosis on the effects of transcranial magnetic stimulation on communication difficulties
Authors: Dias Alice Estevo , Telles Juliana Aparecida Rhein , Sciarini Bruna Helena , Bando Mauricio Ossamu , Agourakis Demetrios Chiuratto , Vidigal Giovanna de Paula , Caetano Andre Virgilio dos Santos , Monteiro Carlos Bandeira de Mello , Silva Talita Dias da
Published: July 2023

Introduction: Multiple sclerosis (MS) can trigger difficulties in communication. Transcranial magnetic stimulation (TMS) is a treatment option. Objectives: To analyze the self-reported communicative ability of people with MS undergoing TMS. Methods: The protocol consisted of 10 interventions by TMS (primary motor cortex, left dorsolateral pre-frontal cortex). The domain 1 of the self-administered WHODAS 2.0 Disability Rating Scale was used before and after (30 days) TMS to identify patient’s opinion of communication. Scores ranged from 0 = minimum difficulty to 100 = maximum. Results: The study comprised 30 people with MS: 22 women, 8 men, age 33– 68 years (mean = 50.0, standard deviation [SD] = 10.6), EDSS 0-6.5 (mean = 4.6, SD = 1.9), time diagnostic 1–24 years (mean = 10.0, SD = 7.2). All patients mentioned preserved ability for general understanding of the interlocutors’ speech. Prior to TMS, n = 18/60% had moderate difficulty concentrating (including speech content/subject), moderate/severe to n = 24/80% in recent memory, n = 10/33%) in problem solving, and n = 10/33% in learning, fundamental mental and reasoning activities for communication, activity reported with a moderate degree of difficult in n = 18/60% to start and maintain conversations due to inability to recall words (language disorder) or impairment in speech intelligibility (dysarthria). Self-reports pointed to a decrease in difficulties after TMS. Conclusion: We observed that WHODAS 2.0 seems to be a favorable both to identify the patient-reported outcome measures about the communicative difficulties, and to analyze the effects of TMS, which, in turn, showed potential to improve verbal communication and requires longitudinal investigation.
Acute cerebellar ataxia due to Dengue fever: case presentation and four-year follow-up
Authors: Holanda Arthur Cesário de , Oliveira Daniel Alves de , Arca Vitor Maia , Maranhão Eduardo , Silva Luísa van der Linden Ferreira da , Bezerra Marcos Eugênio Ramalho , Melo Eduardo Sousa de
Published: July 2023

Case presentation: A 70-year-old female was admitted due to imbalance associated to high fever, headache, photophobia, myalgia, and emesis for 5 days. She denied other symptoms or predisposing agents. At examination, there was a global asymmetric cerebellar syndrome, without other findings. Laboratory work-up showed lymphocytosis, leucopenia, thrombocytopenia, and increased liver enzymes. Serologic exams were negative for syphilis, HIV, hepatitis B and C viruses, CMV, rubella, toxoplasmosis, and trypanosomiasis in peripheral blood, and for CMV, herpes simplex and varicella-zoster viruses, and toxoplasmosis in cerebrospinal fluid. Brain MRI with angiography was unremarkable. During hospital stay, there was complete recovery of systemic symptoms and gradual improvement of the cerebellar syndrome. She was discharged for outpatient follow-up, during which a positive IgM (MAC-ELISA) for Dengue virus was identified. First evaluation was 54 days after onset; she had a mild subjective imbalance complaint, with normal neurological exam. She has been followed for four years since onset, remaining asymptomatic, without any cerebellar signs. Discussion: Neurotropism in Dengue fever, as direct viral or immunomediated damage, has been well recognized. Its spectrum comprises many presentations; however, association with cerebellar syndrome is extremely rare, with only seven other cases published. Acute cerebellar ataxia is characterized by normal neuroimaging and complete recovery up to three years. In Dengue cases, recovery happened from one week to two months. Currently, there are no other reports with long-term follow-up. Conclusion: Dengue virus is a rare, but probably underdiagnosed, cause of acute cerebellar ataxia. Recovery is fast, and, in our case, persistent, without recurrence or evolution to any degenerative disease.
History of neurology in São Paulo at the first half of the 20th century: a systematic review
Authors: Costa Mateus Magalhães Soares da , Pereira João Pedro de Sá , Silveira Laura Victória Miranda
Published: July 2023

Neurology in São Paulo was initiated at the beginning of the XX century, with the creation of the Paulista School of Medicine. This article aims to analyze the emergence of Neurology in the state of São Paulo and the influences it received. To this end, we conducted a systematic search in an electronic database, Scielo. In this context, in the 20th century, neurology studied in São Paulo was greatly influenced by the science practiced in France, since in 1882 the specialty was initiated at the University of Paris. Discussions about the diseases in this area were discussed at the Santa Casa de Misericórdia in São Paulo. Another important place for the development of neurology in São Paulo was the creation of the neuropathology and cerebrospinal fluid laboratory, in 1924, at the Hospital de Juqueri. In the 1920s, the teaching of clinical neurology was created at the Faculty of Medicine by Enjolras Vampré, known as the father of neurology in São Paulo. In the 1930s, there were major changes in the areas of brain pathology, diagnosis of diseases that affect the central nervous system, and therapy. All of this was used at Hospital de Juqueri and Faculdade Paulista de Medicina. Among the prominent methods used were pneumoencephalography, cerebral arteriography, and cerebral leucotomy. Some literary works were fundamental for the dissemination of knowledge of Neurology in the society of São Paulo, namely “Memories of the Hospital of Juqueri” from 1924 and “Archives of Assistance to Psychopaths” from 1936. Neurology underwent a major evolution at the end of the first half of the twentieth century, however, it became expensive and inaccessible to a large part of the population, especially at a time before the creation of the Unified Health System, making the poorest marginalized concerning the treatment of neurological diseases that affected the society of São Paulo at the time.
Primary coenzyme Q10 (COQ10) deficiency: clinical presentation of a new variant in COQ7 gene
Authors: Alvarenga Tarcísio Nunes , Santos Patrick Emanuell Mesquita Sousa , Baston Ana Beatriz Marangoni , Pozzobon Pedro Machry , Lemos Ana Flávia Andrade , Foloni Maria Clara , Nakao Natalia de Castro Fim
Published: July 2023

Cases reports: Two females from different families, 34 and 16 years old, who started at puberty with distal weakness in lower limbs and difficulty in walking. The youngest had a history of parental consanguinity. The oldest also developed symptoms of cerebellar ataxia. Both patients had joint hypermobility. After physical exercise, both showed increased serum levels of creatine phosphokinase, but only one of them showed increased lactate. Both electroneuromyography showed motor neuropathy, predominantly in lower limbs, with axonal and demyelinating pathophysiology, with probable superimposed pre-ganglionic involvement. Both genetic tests showed homozygous pathogenic variation in COQ7 gene, described as Chr16:19.067.667, which leads to methionine substitution and impaired protein traduction. Discussion: Primary COQ10 deficiency is a heterogeneous group of mitochondrial disorders caused by defects in proteins involved in COQ10 biosynthesis. It’s inheritance usually is autosomal recessive. Mutations in 10 genes directly involved in coenzyme Q10 synthesis and collectively named “COQ genes” have been identified. Clinical spectrum may overlap encephalomyopathies, ataxia, neuromyopathy, spastic paraplegia and even impairment of another organs. Only four COQ7 deficiency patients have been reported so far. In addition, cases reported here are related with a new variation in COQ7 gene. All reported COQ7 deficiency patients have asian ancestry, which is not the case of patients related here. Some improvement can occur by COQ10 supplementation, which was initiated in both cases. Conclusion: The diagnosis of primary COQ10 deficiency is limited by factors like rarity, heterogeneous phenotypes and unavailability of genetic testes, which favors under or misdiagnosis. Discovery of new cases and mutations can increase our knowledge about this condition, make possible the diagnosis, consequently look for dysfunction of other organs and try a specific treatment.
Association between risk of obstructive sleep apnea and stroke recurrence: partial results of a cohort
Authors: Novais Aurea Maria Lago , Rogério Beatriz Santos , Branco Renan Carvalho Castello
Published: July 2023

Introduction: Obstructive sleep apnea (OSA) is a disease of upper airways,diagnosed with polisomnography,that is well associated with stroke through diverse mechanisms.Despite that,it still lacks studies about its role in prognosis of stroke,especially in stroke recurrence. Objectives and methods: This study aims to elucidate the possible association between stroke recurrence and risk of OSA.We performed a cohort. Patients were evaluated of risk of OSA with STOP-Bang and SOS scores and remotely evaluated with Rankin, Barthel, questioned about stroke recurrence and another hospitalization during 3.6 and 12 months. We performed univariate analysis (T test,Mann-Whitney or chi-square) and a multivariate analysis with logistic regression (considering P < 0.05). Results: We obtained 190 patients: 7 patients already finished the study and 78 started. 48.9% female, mean age 63.6 ± 6.43 years, mean body mass index 25.69 ± 5.64 kg/m2 , mean SOS 11.65 ± 6.43, mean STOP-Bang 3.22 ± 1.45. Rankin in 3 months mean 2.89 ± 1.81; 6 months mean 2.67 ± 1.89; 12 months mean 5 ± 1.95. Barthel 3 months 62.51 ± 33.44; 6 months 72.40 ± 34.78; 12 months mean 35.40 ± 46.59. 3.7% were hospitalized due to cardiovascular causes; 2.1% due to infection causes and 4.7% due to other causes. 2.6% evolved to death and 1.6% recurred with stroke. Considering STOP-Bang, we had in univariate analysis Rankin 6 months (P = 0.06), Barthel 12 months (P = 0.07) and hospitalization of other causes (P = 0.1). Considering SOS, we obtained stroke recurrence, Rankin 12 months (P = 0.1) and death (P = 0.03). In multivariate analysis, to STOP-Bang, we had Barthel 12 months (P = 0.03); to SOS, it was not possible to perform due to reduced number of stroke recurrence and death. Conclusion: Preliminary results already showed association between OSA and recurrence stroke, which can lead us to a differential approach. Considering the most successful research about this theme obtained 1.2% of recurrence, the study is on the way to elucidate this question.
Biological activity of dried infused sapodilla (Manilkara zapota) leaf tea formulated with different milk and sugar contents
Authors: PUTSON Pathamaporn , WANIKORN Bandhita , SAE-TAN Sudathip , POOLSAWAT Thitirat
Published: July 2023

Milk tea is a popular global beverage, but it also has high sugar and fat contents that can lead to chronic diseases. Sapodilla (Manilkara zapota) leaves contain various phenolic compounds with significant antioxidant and health benefits, but the biological impacts of interactions between sapodilla and other food ingredients in food systems have not been investigated. This study assessed ingredient interactions with the biological properties of functional sapodilla milk tea. Dried sapodilla leaves were infused with hot water at 1 g/120 mL and 1 g/68 mL and formulated with almond milk, soy milk, fat-free cow milk, and lactose-free cow milk. Each formulation was determined for color, total phenolic content, and total antioxidant activity using ABTS and FRAP assays. Two sweeteners, white sugar and smart-branded sugar, were added and tested for antioxidant capacity and sensory acceptability. The formulations were measured for estimated glycemic index (GI), antioxidant capacity, and sensory acceptability compared to commercial products. Results revealed a prototype with a lower estimated GI than commercial products (p<0.05) and high overall liking score of 7.6 (n=30). Functional ingredients from natural sources such as sapodilla leaves can be successfully incorporated into foods, providing novel functional product categories and new commercial opportunities.
Data from LEO 2018 – Living with Low Literacy
Authors: Buddeberg Klaus , Skowranek Kristin , Dutz Gregor , Grotlüschen Anke
Published: July 2023

The study “LEO 2018 – Living with Low Literacy” examines the reading and writing skills of adults aged between 18 and 64 years in Germany. It includes a literacy assessment and an extensive background questionnaire containing sociodemographic variables as well as information on literacy-related everyday practices and domain-specific basic skills (digital, financial, health-related, policy-related). The data was collected in 2018 as part of a household survey (N = 7,192). The dataset is available for secondary use at the repository of GESIS Leibniz Institute for the Social Sciences as a Public Use File and as a Scientific Use File. The dataset offers a reuse potential for different research fields like financial literacy, health literacy, political literacy, digital literacy and with three variables about vulnerability even for psychological research questions.
NATURAL REGENERATION IN MIXED PLANTING FOR ECOLOGICAL RESTORATION IN THE COASTAL PLAIN OF PARANÁ STATE, BRAZIL
Authors: Mattar Eduardo Abilhoa , Nakajima Nelson Yoshihiro , Ângelo Alessandro Camargo , Carpanezzi Antônio Aparecido , Neves Edinelson Maciel , Britez Ricardo Miranda
Published: July 2023

Pastures occupy approximately 20% of the Brazilian territory and a significant part of these areas are degraded and have legal environmental liabilities. Ecological restoration is necessary to remedy this liability. The objective of the present study was to determine the effectiveness of a forest restoration planting in an area previously used as buffalo pasture, through floristic and phytosociological parameters of natural regeneration. The study area was densely populated by invasive exotic grasses (Urochloa spp.) until 2006, when, after eliminating the grasses, six native tree species were planted at 2.5 × 1.6 m spacing. A total of 73 terrestrial plant species were found, the most important being Alchornea glandulosa Poepp. & Endl. - heliophilous, which showed high abundance in all strata. The restoration methodology employed was effective in triggering natural succession in the study area, resulting, after 12 years, in floristic and structural parameters consistent with the initial stage of development of the alluvial Dense Ombrophylous Forest. It is inferred that the well-preserved landscape in the region has been determinant in providing the propagules and dispersers that made the observed species richness possible, while the planting tends to have contributed with the control of grasses and with the recovery of the forest environment, facilitating the arrival and development of these propagules. Evidence of soil degradation by use as pasture was observed, and in former buffalo bathing areas neither restoration planting nor natural regeneration developed.
INITIAL GROWTH OF Citharexyllum myrianthum plants UNDER PLANTING FERTILIZATION
Authors: Silva Oclizio Medeiros das Chagas , Leles Paulo Sérgio dos Santos , Lopes Lucas Nunes , Santos Gilsonley Lopes dos , Delgado Lucas Britto , Silva Eduardo Vinicius da
Published: July 2023

The objective of this work was to evaluate the initial growth of Citharexyllum myrianthum under the influence of three sources of planting fertilizers, in conditions of 18 L pots. The treatments used were, as follows: absolute control; 5 L of biosolid/pot; 300 g of natural rock phosphate (NRP), and 200 grams of NPK 06-29-06. The seedlings were grown in pots in full sun, supplemented with Dystrophic Red Yellow Latosol. At 150 days after transplanting, the plants were measured, obtaining the height of the aerial part and the diameter of the stem. Then, the increment of these two variables was calculated. Subsequently, the leaves were removed to determine the leaf area (LA), separating the aerial part from the root system, and then packed in a paper bag and placed in an oven at 65ºC, for drying until reaching constant weight. After weighing this material to obtain the dry matter of the aerial part (APDM) and root (RDM). The leaves were ground to determine the foliar contents of N, P, K, Ca, and Mg. To evaluate the effect of treatments on the soil, samples were taken from the pots to determine the levels of macronutrients, organic matter, and CEC(t). It was found that the LA and APDM of plants fertilized with NPK showed significantly higher values when compared to plants cultivated in the control treatment. It is recommended to fertilize Citharexyllum myrianthum plants with 200 grams of N-P-K 06-29-06/hole or with 5 L of biosolid.
MECHANIZED WOOD HARVESTING APTITUDE ZONING
Authors: Ramalho Antonio Henrique Cordeiro , Fiedler Nilton Cesar , Falcão Ruan Specimille , De Souza Kaíse Barbosa , Moreira Taís Rizzo , Macedo Thiago Nunes da Silva
Published: July 2023

The need to increase forest enterprises productivity has demanded higher levels of mechanization. The objective of this study was to evaluate the suitability of areas in Espírito Santo State to implement mechanized wood harvesting using short log system. To prospect suitable areas for mechanization, algebra map of Eucalyptus edaphoclimatic zoning, land use and occupation, slope, conservation units and their respective buffer zones was performed. Thus, suitability zones were defined based on edaphoclimatic conditions for evaluated species, with temperatures between 19 and 26ºC, water deficit from 30 to 210 mm and annual average rainfall between 900 and 1800 mm defined as suitable. Land use and occupation was classified as fit, fit with type II limitation, fit with type III limitation and unfit. For slope classes, three categories were created: fit (0 - 27º), fit with limitation type I (27.1 - 35º) and unfit (> 35º). Results showed that State has 39.45% of its entire area able to implement mechanized wood harvesting for Eucalyptus and 47.91% is unfit. With results, authors concluded that Northeast micro-region stood out with large areas suitable for Eucalyptus harvest mechanization and employed methodology has potential for use and adaptation in other study areas around world.
The Role of the General Practitioner-Family Doctor in the Pharmacotherapy of Tuberculosis During the War
Authors: Vovk Daryna , Puhach Oleksandr , Bachynska Liliia , Poryvai Rita , Shkyria Mykhailo
Published: July 2023

The role of the general practitioner-family physician in the pharmacotherapy of tuberculosis during the war is extremely important. The military conflict can cause an increase in cases of tuberculosis due to the deterioration of hygienic conditions, internal displacement of the population, evacuation of patients, insufficient medical and pharmaceutical assistance. In a wartime setting, family physicians may be the primary providers of early diagnosis and pharmacotherapy for many tuberculosis patients. Crowding of people in damp shelters, insufficient nutrition, stress. The role of family physicians is to properly treat and monitor patients, prevent the spread of tuberculosis, and collaborate with other specialists for optimal management of this disease.
A Case Series of Surgically Treated Distal Radius Fractures: Implant Costs and Their Effect on Patient Outcomes
Authors: Doxey Stephen A. , Huyke-Hernández Fernando A. , Robb Jennifer L. , Bohn Deborah C. , Cunningham Brian P.
Published: July 2023

Introduction:

Distal radius fractures (DRFs) are common injuries, warranting a need to analyze the cost of treatment. The purpose of this study was to analyze the effect of implant costs on patient-reported outcomes in DRFs.

Methods:

A PRO registry was retrospectively reviewed for isolated, surgically treated DRF patients. A total of 140 patients met criteria to be included in this study. Implant cost was obtained from the chargemaster database.

Results:

The average total implant cost was $1,289.67 ± 215.32. The average Patient-rated Wrist Evaluation scores preoperatively, at 6 weeks, and at 12 weeks were 70.8 ± 20.1, 36.6 ± 21.1, and 22.8 ± 18.0, respectively. No statistically significant relationships were observed between cost and Patient-rated Wrist Evaluation scores at 6 weeks or 12 weeks (r = −0.05, P = 0.59; r = −0.04, P = 0.64, respectively). Implant costs were shown to not be affected by fracture complexity (AO/OTA classification: 23A = $1,335.50, 23B = $1,246.86, and 23C = $1,293.14).

Discussion:

The total cost of implants did not influence patient outcomes indicating that patients receive no additional benefit from more costly constructs.
Comparison of business environment in the chosen regions
Authors:   Department of Management of Earth Resources, Faculty BERG, Institute of Earth Resources, Technical University Košice,Košice, Slovakia, Gabániová L’ubomíra , Culková Katarínaˇ ,   Department of Management of Earth Resources, Faculty BERG, Institute of Earth Resources, Technical University Košice,Košice, Slovakia, Seˇnová Andrea ,   Department of Management of Earth Resources, Faculty BERG, Institute of Earth Resources, Technical University Košice,Košice, Slovakia
Published: July 2023

Sustainable development of the regions is presently an often discussed theme, mainly due to the worldwidesituation. The goal of the contribution is therefore to find regions in Slovakia and Ukraine that have the possibilityto have mutually advantageous ways of cooperation. The selection of the regions results from the comparison ofEuropean Union (EU) Member State’s situations and not EU Member State situations. The situation in the regionsis compared according to the regional gross domestic product per capita, the unemployment rate in the region andthe average monthly wage of employees in the regions. The results of the contribution show possible cooperationof the analyzed regions in business, mainly in the area of industrial production, with unemployment decreasing.The use of the results is in the area of finding strategies for improvement and cooperation.
Potential trade effects of geographical indications
Authors:   Lecturer-STEM Faculty, Arden University, Berlin, Germany, Robinson Rachel John
Published: July 2023

Geographical indications (GI) are a value that is added to a product to signify its heritage and uniqueness to make itstand out in the market space and give it a competitive edge. GI is one of the subtypes in the intellectual property(IP) space in the global trade. It is governed by the World Intellectual Property Organization (WIPO). Issues andcontroversies are a very common phenomenon surrounding GI, mostly amongst the producers but rarely reachingthe customers. In terms of the consumers, GI-vouched products provide quality, reputation, and exclusivity toenable them to purchase with confidence. In present practice, GI is widely used in Agri-based products that requirespecific manufacturing skills and traditions. According to WIPO reports from 2018, 80% of the accounted GIs arefor agricultural products and foodstuffs, with the remaining 20% being for non-agri-based products. This proposalis going to view the prospects of both Agri-based and non-agri-based producers’ problems across regions andsuggest one common unified approach to overcome associated state problems strategically through the economictheory of clubs.