bluuebunny/crossref_metadata_2025 huggingface dataset:
Динамика оптической плотности первого ребра у мужчин в возрастном аспекте
Authors:   кафедра анатомии человека Курского государственного медицинского университета, Ладыгин Константин , Яшина Ирина ,   кафедра анатомии человека Курского государственного медицинского университета, Клочкова Светлана ,   кафедра анатомии человека Российского университета дружбы народов, Ладыгина Аделина ,   Медицинский институт, факультет «Лечебное дело и педиатрия» НИУ БелГУ, Яшин Федор ,   кафедра анатомии человека Курского государственного медицинского университета
Published: June 2022

Изучение динамики изменения оптической плотности костной ткани первого ребра у мужчин в разных возрастных группах, без признаков остеопороза.
Токсическое поражение печени стимулирует дифференцировку СК19+/SOX9+ клеток внутрипеченочных желчных протоков и проточков в холангиоциты и гепатоциты
Authors:   Кафедра гистологии, цитологии и эмбриологии, Ректор, Кафедра хирургии ФПК и ПК, Лечебный факультет, Витебский государственный ордена Дружбы народов медицинский университет, Лебедева Елена , Щастный Анатолий ,   Кафедра гистологии, цитологии и эмбриологии, Ректор, Кафедра хирургии ФПК и ПК, Лечебный факультет, Витебский государственный ордена Дружбы народов медицинский университет, Бабенко Андрей ,   Кафедра биоорганический химии, Медицинский факультет иностранных учащихся, Белорусский государственный медицинский университет
Published: June 2022

В настоящее временя клеточно-молекулярные механизмы регенерации и резервные возможности печени при ее токсическом поражении до конца не изучены. Цель работы – выяснить роль СК19+ и SOX9+ клеток на разных стадиях токсического поражения печени.
К вопросу оптимизации образовательного процесса по дисциплине «Гистология, эмбриология, цитология» в условиях гибридного обучения
Authors:   Кафедра гистологии, эмбриологии, цитологии, Курский государственный медицинский университет, Миронов Сергей , Прусаченко Андрей ,   Кафедра гистологии, эмбриологии, цитологии, Курский государственный медицинский университет, Никишина Нина ,   Кафедра гистологии, эмбриологии, цитологии, Курский государственный медицинский университет
Published: June 2022

На современном этапе, запрос общества к качеству подготовки выпускников медицинских вузов выражается в количестве и уровне сформированности универсальных и профессиональных компетенций. Анализ современного состояния преподавания морфологических дисциплин на основе компетентностной теории обучения в медицинских вузах диктует необходимость обсудить некоторые его проблемы с целью поиска оптимальных решений.
Сосково-ареолярный комплекс молочной железы у женщин: клинико-морфологические аспекты нейроангиоархитектоники
Authors:   НИИ морфологии человека им. академика А.П. Авцына, Мнихович М. , Сорокин Е. ,   ФГБНУ «РНЦХ им. акад. Б.В. Петровского, Безуглова Т. ,   НИИ морфологии человека им. академика А.П. Авцына, Романов А. ,   НИИ морфологии человека им. академика А.П. Авцына, Лозина М. ,   ФГБНУ «РНЦХ им. акад. Б.В. Петровского, Ширипенко И. ,   ФГБНУ «РНЦХ им. акад. Б.В. Петровского, Сидорова О. ,   ФГБНУ «РНЦХ им. акад. Б.В. Петровского, Каминер Д. ,   ФГБНУ «РНЦХ им. акад. Б.В. Петровского, Снегур С. ,   ГБУ РО "Областная клиническая больница", Павлова Ю. ,   ГБУ РО "Областная клиническая больница"
Published: June 2022

Проследив этапы развития онкологической хирургии, можно отметить постепенный переход от радикальных мастэктомий (Холстед) к менее травматичным и менее объемным операциям, например по Маддену или Пирогову. Последние особенно часто встречаются в онкопластике и их смысл заключается в сочетании эффективного лечение онкологических новообразований и максимально возможной косметичности. Необходимым условием для достижения такого результата является сохранение целостности сосково-ареолярного комплекса (САК).
Системный клеточный иммунитет и развитие катаракты
Authors:   Тамбовский филиал ФГАУ «НМИЦ «МНТК «Микрохирургия глаза» им. акад. С. Н. Фёдорова», Османов Р.
Published: June 2022

Среди причин нарушения зрения катаракта занимает значительный удельный вес, что указывает на необходимость изучения причин ее развития, в структуре которых в последние годы отводится важная роль нарушению иммуннорегуляторных реакций. Однако участие составляющих системного клеточного иммунитета в формировании различных форм катаракты остается практически неизвестным.
Calculation of the ionization potential of zinc and graphene phthalocyaninates on the surface of dielectrics
Authors:   St. Petersburg State University, Kuranov Dmitry Yu. , Andreeva Tatiana A. ,   St. Petersburg State University, Bedrina Marina E. ,   St. Petersburg State University
Published: June 2022

A mathematical model is proposed for calculating the ionization potentials of molecules on the surface of dielectrics in order to quantify changes in the electronic characteristics of materials on a substrate. The semiconductor and photoelectronic properties of nanosystems based on phthalocyanine derivatives are determined by the electronic structure of molecules. Based on the zinc phthalocyaninate molecule ZnC32N8H16, model structures are constructed that increase this molecule by attaching benzene rings ZnC48N8H24, ZnC64N8H32 and a model simulating the film structure of Zn4C120N32 H48. Graphene was considered as a nanostructure modeling a fragment of a monomer lm. The ionization potentials of these compounds on the surface of magnesium oxide, sodium chloride and silicon are calculated. In the presence of a substrate, the ionization potentials of all nanostructures decrease, while the values of the surface ionization potentials remain fundamentally dierent in their magnitude for all compounds. The compound ZnC64N8H32 sprayed onto the surface exhibits the best photoelectronic properties, its surface ionization potential is comparable to graphene.
Cooperative game theory methods for text ranking
Authors:   Federal Research Center “Karelian Research Center of the Russian Academy of Sciences”, Mazalov Vladimir V. ,   Petrozavodsk State University, Khitraya Vitalia A. ,   Federal Research Center “Karelian Research Center of the Russian Academy of Sciences”,   Petrozavodsk State University, Khitryi Andrei V. ,   Federal Research Center “Karelian Research Center of the Russian Academy of Sciences”
Published: June 2022

A method of ranking the corpus of texts of a news portal, based on measures of graph centrality, is proposed. Each text is assigned a vertex of a certain graph, and its structure is determined based on the semantic connectivity of the texts. As a measure of centrality, the Myerson value is used in a cooperative game on a graph, where the number of simple paths in a subgraph of a certain length m is chosen as a characteristic function For different values of m, the ranking based on the Myerson value will be different. For the final ranking, it is proposed to use the ranking procedure based on the tournament matrix. The operation of the ranking algorithm is illustrated by numerical examples related to a specific news porta.
Mathematical modeling of malignant ovarian tumors
Authors:   St. Petersburg State University, Goncharova Anastasiya B. , Kolpak Eugeny P. ,   St. Petersburg State University, Vil’ Maria Yu. ,   St. Petersburg State University, Abramova Alina V. ,   N. N. Petrov National Medical Research Center of Oncology of the Ministry of Healthcare of the Russian Federation, Busko Ekaterina A. ,   St. Petersburg State University,   N. N. Petrov National Medical Research Center of Oncology of the Ministry of Healthcare of the Russian Federation
Published: June 2022

The article explores modeling the development of ovarian cancer, the treatment of this oncologicaldisease in women, the assessment of the time to achieve remission, and the assessment of the time of the onset of relapse. The relevance of the study is that ovarian cancer is one of the most common cancers in women and has the highest mortality rate among all gynecological diseases. Modeling the process of the development of the disease makes it possible to better understand the mechanism of the development of the disease, as well as the time frame of the onset of each stage, as well as the assessment of the survival time. The aim of the work is to develop a model of an ovarian tumor. It is based on a model of competition between two types of cells: epithelial cells (normal cells) and tumor cells (dividing cells). The mathematical interpretation of the competition model is the Cauchy problem for a system of ordinary differential equations. Treatment is seen as the direct destruction of tumor cells by drugs. The behavior of solutions in the vicinity of stationary points is investigated by the eigenvalues of the Jacobi matrix of the right side of the equations. On the basis of this model, the distribution of conditional patients by four stages of the disease is proposed. Biochemical processes that stimulate the accelerated growth of the tumor cell population are modeled by a factor that allows tumor cells to gain an advantage in a competitive relationship with epithelial cells. The spatio-temporal dynamics of an ovarian tumor leads to a modification of the competition model due to the introduction of additional factors into it, taking into account the presence of increased nutrition of ovarian tumors, the exit of the tumor from the plane of the ovary, as well as the effect of treatment on tumor cells. The new model describes the interaction conditions with a system of second-order partial differential equations. The results of computer modeling demonstrate an assessment of the distribution of conditional patients by stages of the disease, the time of onset of relapse, the duration of remission, the obtained theoretical results of modeling are compared with the real data.
Hydrogeology and groundwater quality in the Nordic and Baltic countries
Authors: Kitterød Nils-Otto , Kværner Jens , Aagaard Per , Arustienė Jurga , Bikše Jānis , Dagestad Atle , Gundersen Pål , Hansen Birgitte , Hjartarson Árni , Karro Enn , Klavins Maris , Marandi Andres , Radienė Rasa , Retike Inga , Rossi Pekka M. , Thorling Lærke
Published: June 2022

Groundwater utilization and groundwater quality vary in the Baltic and Nordic countries mainly because of different geological settings. Based on the geology, the countries were treated in the following three groups: (1) Fennoscandian countries (Finland, Sweden, and Norway), (2) Denmark and Baltic countries (Estonia, Latvia, and Lithuania), and (3) Iceland. Most of the utilized groundwater resources are taken from Quaternary deposits, but Denmark and the Baltic countries have in addition, important resources in Phanerozoic rocks. The groundwater quality reflects the residence time of water in the subsurface and the chemical composition of the geological formations. Concentrations of ions in the Fennoscandian bedrock are elevated compared to Iceland, but lower than in Denmark and the Baltic countries. Compared to groundwater in the bedrock, groundwater in Quaternary deposits has usually lower concentrations of dissolved minerals. Unconfined Quaternary aquifers are vulnerable to contamination. Examples from Denmark and the Baltic countries illustrate challenges and successful effects of mitigation strategies for such aquifers related to agricultural application and management of nitrogen. Confined and deeper groundwater is better protected against anthropogenic contamination, but water quality may be affected by harmful compounds caused by geogenic processes (viz, sulfide, arsenic, fluoride, and radon).
Nutrient removal and recovery from wastewater by microbial fuel cell-based systems – A review
Authors: Baby Merin Grace , Ahammed M. Mansoor
Published: June 2022

Microbial fuel cell (MFC) is a green innovative technology that can be employed for nutrient removal/recovery as well as for energy production from wastewater. This paper summarizes the recent advances in the use of MFCs for nutrient removal/recovery. Different configurations of MFCs used for nutrient removal are first described. Different types of nutrient removal/recovery mechanisms such as precipitation, biological uptake by microalgae, nitrification, denitrification and ammonia stripping occurring in MFCs are discussed. Recovery of nutrients as struvite or cattiite by precipitation, as microalgal biomass and as ammonium salts are common. This review shows that while higher nutrient removal/recovery is possible with MFCs and their modifications compared to other techniques as indicated by many laboratory studies, field-scale studies and optimization of operational parameters are needed to develop efficient MFCs for nutrient removal and recovery and electricity generation from different types of wastewaters.
Associations of Two Common Polymorphisms in MTHFR Gene with Blood Lipids
and Therapeutic Efficacy of Simvastatin
Authors: Jiang Shanqun , Liu Yu , Lu Cuiping , Li Yajie , Venners Scott A.
Published: June 2022

Background:

Cardio-cerebrovascular disease is an important public health challenge worldwide, and
its complex etiology has not been elucidated fully. The study investigated the relationship between two common
polymorphisms, C677T and A1298C in the methylenetetrahydrofolate reductase (MTHFR) gene, baseline
lipids and the lipid-lowering efficacy of simvastatin in a Chinese hyperlipidemic population.

Methods:

All participants were recruited from Anhui, China. By the extreme sampling method, we selected
subjects with a low response (n=108) and high response (n=106) based on their adjusted lipid-lowering response
to simvastatin administrated for 8 consecutive weeks. Both MTHFR C677T and A1298C loci were genotyped
by the MALDI-TOF MS platform. Serum triglyceride (TG), total cholesterol (TC), low-density lipoprotein
cholesterol (LDL-C), and high-density lipoprotein cholesterol (HDL-C) levels were measured at baseline
and after 8 weeks of oral 20 mg/d tablets of simvastatin.

Results:

Patients with the 677TT genotype had significantly higher baseline TC, HDL-C, and change in HDL-C
(ΔHDL-C) levels after treatment than those with 677CC+CT genotypes (β = 0.207, P = 0.045; β = 0.182, P =
0.026; and β = 0.16, P = 0.002, respectively). Patients with 1298AC+CC genotypes had significantly higher
baseline LDL-C and change in LDL-C (ΔLDL-C) levels (β = 0.276, P =0.043; β = 0.359, P = 0.025, respectively)
than those with 1298AA genotype. We found statistical interactions between the two SNPs in association
with baseline HDL-C (P for interaction = 0.034), TC (P for interaction = 0.069), and TG (P for interaction =
0.034). Baseline TC (P = 0.027) and HDL-C (P = 0.046) and change in HDL-C (P = 0.019) were different
among those with the MTHFR A-T haplotype compared with A-C.

Conclusions:

Our major findings suggest that both MTHFR C677T and A1298C polymorphisms could be important
genetic determinants of lipid traits and drug efficacy of simvastatin. This will contribute to a better understanding
of strategies for personalized medication in Chinese patients with dyslipidemia.
The Role of the LINC01234/miR-433-3p/GRB2 ceRNA Network in
NSCLC Cell Malignant Proliferation
Authors: Wei Wei , Wang Changyong , Zhang Jianfeng , Wang Lele , Wei Lei , Huang Hairong
Published: June 2022

Background:

Non-small cell lung cancer (NSCLC) is associated with high morbidity
and mortality. Dysregulation of lncRNAs leads to NSCLC progression.

Objective:

This study aims to explore the regulatory mechanism of lncRNA LINC01234 in
NSCLC.

Materials and Methods:

LINC01234 expression in NSCLC cells was determined. Cell proliferation
was detected using CCK-8, colony formation, and EDU assays after transfection of siRNA
LINC01234 into H1299 cells and transfection of pcDNA3.1-LINC01234 into H1975 cells. Subcellular
localization of LINC01234 was predicted and the binding relations between LINC01234 and
miR-433-3p as well as miR-433-3p and GRB2 were verified. The expression levels of miR-433-3p
and GRB2 in NSCLC cells were determined. Joint experiments of miR-433-3p inhibitor + si-
LINC01234-1 or oe-GRB2 + si-LINC01234-1 were conducted to verify the role of miR-433-3p
and GRB2 in NSCLC cell malignant proliferation.

Results:

LINC01234 was abundantly expressed in NSCLC cells. LINC01234 silencing reduced
NSCLC cell proliferation while LINC01234 overexpression enhanced cell proliferation.
LINC01234 competitively bound to miR-433-3p and miR-433-3p directly targeted GRB2. miR-
433-3p knockdown or GRB2 overexpression counteracted the repressive effect of LINC01234 silencing
on NSCLC cell malignant proliferation.

Conclusion:

LINC01234 competitively bound to miR-433-3p and promoted GRB2 transcription to
augment NSCLC cell malignant proliferation.
Oak Pollen Allergy in Korea
Authors: Jeong Kyoung Yong , Park Jung-Won
Published: June 2022

Oak pollen allergy is common all over the world and an important cause of pollinosis. The molecular properties of some component allergens have been clearly characterized, while some of them are still waiting for characterization. Studies on some oak component allergens are neglected, possibly because of its high cross-reactivity to birch. However, the utilization of culprit allergen molecules is expected to increase the diagnostic sensitivity and efficacy of immunotherapy. Sensitization to oak pollen along with birch often causes pollen food allergy syndrome to fruits and vegetables. Acorn and wood dust from oak can cause allergic disease. We summarize the distribution and taxonomic classification of oak trees of allergenic importance. Molecular characteristics of the identified component allergens, cross-reactivity, and clinical aspects for diagnosis and immunotherapy are also described with an emphasis on Korean situations.
Recent Progress on the Development and Application of Polymeric Nanofiltration
Membranes: A Mini-Review
Authors: de Almeida Fabiana Rodrigues , de Mello Ferreira Ivana Lourenço , dos Reis Rodrigo Azevedo
Published: June 2022

The inefficiency of conventional water treatment methods in terms of removing micropollutants is prompting research into other technologies. Among these, the process of separation by nanofiltration membranes is particularly promising because of the low operating cost, rapid implementation
of the system, high selectivity and easy integration with other treatment processes. Studies in this area
are recent and there are many avenues for future research. This mini-review describes the main characteristics of the polymeric membranes used for nanofiltration and the various methods and polymer
materials under investigation. At the end, we report the result of a survey conducted on the ScienceDirect, Scopus and Web of Science platforms using different keywords, to depict a global panorama of
the current research involving polymeric nanofiltration membranes. The results revealed a particular
dearth of published studies involving application of these membranes to remove micropollutants with
endocrine disruptive action. Furthermore, research involving nanofiltration membranes utilizing calcium alginate is very recent. This study provides an overview of the investigation of polymeric nanofiltration membranes.
Cardiovascular Toxicities with Chimeric Antigen Receptor T-cell Therapy
Authors: Gill Jashan
Published: June 2022

Chimeric antigen receptor (CAR) T-cell therapy has shown remarkable efficacy in treating
highly refractory and relapsing hematological malignancies in pediatric and adult patients.
However, this promising therapy is limited by severe and potentially life-threatening toxicities. Cytokine
release syndrome (CRS) is the most commonly observed of these toxicities. The cardiovascular
manifestations of CRS include tachycardia, hypotension, left ventricular dysfunction, arrhythmias,
troponin elevation, cardiogenic shock, and pulmonary edema. Recent data suggest that
cardiotoxicities may be transient and reversible in younger patients with few cardiac comorbidities;
however, cardiotoxicities may be fatal in older patients with significant cardiac risk factors. The
literature remains sparse regarding long-term cardiotoxicities associated with CAR-T cell therapy.
Furthermore, consensus guidelines for monitoring and prevention of cardiotoxicities remain illdefined.
Therefore, this review will detail the cardiovascular toxicities of CAR T-cell therapy seen
in clinical trials and observational studies, summarize treatment approaches for CRS, outline the
currently adopted surveillance protocols for CAR T-cell associated cardiotoxicity, and explore the
future directions of research in this rapidly emerging field.
In silico Study and Solvent-free one-pot Synthesis of Tetrahydropyrimidine
derivatives by Mechanochemistry Approach for Targeting Human
Neutrophil Elastase against Lung Cancer
Authors: Patel Ashish , Gandhi Karan , Shah Sweta , Patel Darshan , Chhatbar Shreyas , Shah Drashti , Patel Stuti , Patel Harnisha , Bambharoliya Tushar
Published: June 2022

Background:

Pyrimidine derivative has evinced its biological importance in targeting
lung cancer by inhibiting neutrophil elastase.

Methods:

All THPM derivatives were synthesized by the grindstone method at ambient temperature
followed by molecular docking study for efficient binding interaction of THPM compounds by
targeting human neutrophil elastase (HNE) (PDB ID: 5A0A) and In-silico ADMET study using
PkCSM. Moreover, all synthesized compounds were characterized by spectroscopy techniques and
screened for anti-cancer activity using in vitro HNE assay kit.

Results:

We reported a one-pot solvent-free mechanochemical approach for synthesizing tetrahydropyrimidine
(THPM) derivatives from various aromatic aldehydes, ethyl cyanoacetate, and urea
followed by in silico study and evaluation against human neutrophil elastase (HNE) for treatment of
lung cancer. We calibrated the best molecules that bound to specific targets more efficiently using a
molecular docking approach and provided the desired efficacy. In-silico ADMET studies revealed
that all best-scored compounds had drug-like characteristics for potential use as human neutrophil
elastase inhibitors (HNE) in lung cancer treatment. Additionally, the in vitro studies revealed that
compounds 1, 2, and 8 show potent HNE inhibitory activity for lung cancer treatment.

Conclusion:

In a nutshell, the tetrahydropyrimidine (THPM) scaffold and its derivatives may serve
as potential HNE inhibitors for the development of a promising anti-cancer agent.
Formulation and Characterization of Self-Microemulsifying Drug Delivery
System (SMEDDS) of Sertraline Hydrochloride
Authors: Sharma Sanjay , Kanugo Abhishek , Kaur Tejvir , Choudhary Deepak
Published: June 2022

Background:

Sertraline hydrochloride is the most widely used selective serotonin reuptake inhibitor (SSRI) for the treatment of several depressive disorders. Its applicability is limited due to extensive metabolism and poor oral bioavailability of 44 %.

Objective:

The current research focused on improving the solubility and oral bioavailability of Sertraline by using microemulsions developed by a self-micro emulsifying drug delivery system (SMEDDS) for significant antidepressant action.

Methods:

SMEDDS were developed by selecting appropriate proportions of oil, surfactant, and co-solvents and out of them isopropyl myristate, tween 80 and propylene glycol were identified as best. The emulsification zone was demonstrated by a ternary phase diagram, and compatibility was confirmed with Fourier-transformed infrared spectroscopy (FT-IR). The formulated SMEDDS were characterized for robustness to dilution, globule size (GS), polydispersity index (PDI), viscosity, in-vitro dissolution and diffusion study, and drug release kinetics study.

Results:

All the batches (A1-A9) passes the test and A3 was selected as an optimized batch that doesn’t show phase separation, precipitation with globule size (101 nm), PDI (0.319), drug content (99.14±0.35 %), viscosity (10.71±0.02 mPa), self-emulsification time (46 sec), in-vitro drug release (98.25±0.22 %) within 8 h, release kinetics (Higuchi) and effective antidepressant in in-vitro diffusion studies.

Conclusion:

An optimized batch A3 observed circular in shape estimated by Transmission electron microscopy (TEM) and passes all the thermodynamic stability testing with loss of 0.271 mg of the drug after 90 days and showed marked antidepressant action with higher stability.
A Review on Wire-Driven Flexible Robot Manipulators
Authors: Tang Dedong , Cheng Chao , Xiao Limei , Tang Chunyang , Lv Xin , Wang Gang
Published: June 2022

Background:

At present, with the rapid development of technology in medical treatment and rescue, how to reduce the operation complexity caused by limited space has become one of the hot topics. For example, in search and rescue, it is difficult for people to enter these high-risk areas due to various restricted geographic environments. During some medical treatment processes, minimally invasive surgery is difficult to operate because of its small incision. In order to solve these problems, a kind of Wire-Driven Flexible Robot Manipulator (WDFRM) has been developed. The WDFRMs have better flexibility and greater degrees of freedom (DOF) than the traditional rigid manipulators, and play an important role in these extreme operation fields.

Objective:

The paper aims to report the latest progress in the studies of the WDFRMs, and provides a reference for readers in this field.

Method:

By summarizing various productions and patents related to the WDFRMs, the structural characteristics, differentiations, applications of the WDFRMs are proposed.

Results:

Different types of WDFRMs are compared, analyzed, and classified according to their structural characteristics and supporting mode. The technical problems of the WDFRMs are pointed out, and the future development direction of this research field is predicted.

Conclusion:

According to their structural characteristics, the research shows that WDFRMs can be divided into Wire-Driven Serpentine Flexible Robot Manipulators (WDSFRMs) and Wire-Driven Continuum Flexible Robot Manipulators (WDCFRMs). WDFRMs will have more applications in medical treatment, rescue, and military affairs. The structure, stiffness and accuracy of the WDFRMs still need to be improved continuously.
Silicene Transistors: Silicon-based Nanoelectronics from a Single Atom Layer
Authors: Nguyen N.-T.
Published: June 2022

The discovery of graphene, a single-atom thin sheet of carbon, led to the worldwide race for the discovery
of similar two-dimensional materials of other elements, especially of common semiconductor materials
such as silicon and germanium. Although graphene may be electrically the most conductive material, it is not
suitable for making a transistor because of the lack of an energy band gap. In contrast, silicene and germanene,
single-atom layers of silicon and germanium, pose a small band gap that can be used for making nanoelectronic
transistors. A recent work has demonstrated the proof of concept of this transistor, which is made of a
single layer of silicon atoms.
Q-factor Tuning and Closed-loop Control for a Resonant Electric Field Micro-Sensor
Authors: Liu Heng , Meng Rui-li , Zhang Hong-Qun , Xiong Feng
Published: June 2022

A method that utilizes vibration velocity signal and differential combs to improve the equivalent Q factor
of MEFS is proposed in this study to address charge accumulation on the metal cap surface of an MEMS-based
electric field sensor (MEFS) with vacuum package. The MEFS system is characterized by a high degree of nonlinearity,
so the averaging method is used to analyze system stability and vibration amplitude. Theoretical and simulation
results show that the proposed method is feasible. Experiment results indicate that the larger is the referenced
voltage, the larger is the zoom stable vibration amplitude, and the shorter is the transient time. The resulting
signal-to-noise ratio is about 92 dB, and the vibration amplitude shows a deviation of 0.2% in 6 min.
Clerodendrum colebrookianum Walp: An Insight into its Pharmacology,
Expository Traditional Uses and Extensive Phytochemistry
Authors: Das Ratna Jyoti , Pathak Kalyani , Bordoloi Smita , Saikia Riya , Alqahtani Saif Aboud , Saharia Jon , Devi Mary , Mazumder Bhaskar
Published: June 2022

Introduction:

Clerodendrum colebrookianum Walp (Family, Verbenaceae) is one of the beneficial medicinal plants, used by the traditional people of this Northeast region of India due to its cardioprotective action and most widely known as “Nefafu” in Assam, “Arun” in Nagaland and “Phuinum” in Mizoram. Clerodendrum colebrookianum is found extensively in the South as well as Southeast Asia. The Mizo natives of the Northeast, India expanse of India claim that the hypertensive populace's minor occurrence in the middle of their society member is because of the habitual ingestion of this medicinal plant as vegetables.

Aim:

This review summarizes the ethnopharmacology, selected scientific evidence on the pharmacological properties and phytochemistry of Clerodendrum colebrookianum Walp. This plant is generally considered the most significant herbal variety practiced in the therapy of hypertension by various communities of Northeast India.

Methods:

The review covers literature about the evidence-based ethnopharmacology, therapeutic potential, and phytochemistry of Clerodendrum colebrookianum Walp. Literature was collected from non-English journals and English from scientific databases via electronic search (Elsevier, Google Scholar, PubMed, Scopus, Springer, Web of Science, Wiley online library) and Ph.D. thesis databases.

Results:

Evidence suggests that the extracts and some compounds from. Clerodendrum colebrookianum Walp possesses abdominal pain, anthelmintic, antidote, blood purifier, colics in infants, cough, diabetes, diarrhea, and dysentery, gastric disorders. It also has cardioprotective potential, which is a valid scientific basis for consuming it for health benefits in the northeast region of India.

Conclusion:

Scientific evidence suggests that Clerodendrum colebrookianum Walp's immense potential to treat diabetes, hypertension, and other chronic diseases.
Memoria, acontecimiento, objeto y lugar
Authors: Pérgolis Valsecchi Juan Carlos , Quijano Gómez Estefanía
Published: June 2022

En esta investigación, realizada para ser presentada en la Cátedra Anual de Historia Ernesto Restrepo Tirado, del Museo Nacional, Bogotá, Colombia, se intenta revisar las dualidades espacio / lugar, historia / memoria y relato oficial / múltiples relatos, a partir de las siguientes hipótesis: 1. Los acontecimientos convierten los espacios en lugares, por lo tanto, en “lugares de memoria”; 2. La historia propone un relato oficial único; la memoria se nutre de múltiples relatos. En este texto, se observan esas hipótesis en tres lugares: el histórico Puente de Boyacá, el Puente del Común y el puente urbano de la calle 116 con Avenida Boyacá, en Bogotá. Para concluir, se observan en el graffiti, como ejercicio de memoria efímera; y en el monumento Prometeo de la Libertad, del maestro Arenas Betancourt, en Ciénaga, Magdalena. Finalmente, se intenta una reflexión sobre la presencia del objeto de la memoria, a través de la intervención en el muelle de Puerto Colombia, Atlántico.
Capitolio Nacional de Colombia: aspectos biográficos del “Enfermo de Piedra” entre 1912 y 1914
Authors: Pinzón Rivera José Alexander
Published: June 2022

En la historia de la arquitectura colombiana, una de las varias edificaciones que más tardó en construirse fue el Capitolio Nacional de Colombia. De allí, que recibiera el apelativo de “Enfermo de Piedra”. Si bien, el concepto original del edificio arrojó, a mediados del siglo XIX, un monumento símbolo del poder nacionalista, predominantemente horizontal y sin cúpula, hubo varios intentos por cambiar esa idea, desde finales del mismo siglo y hasta las primeras décadas del siguiente. Teniendo en cuenta lo anterior, el presente escrito se concentra en el momento en que el Gobierno nacional, por medio del Ministerio de Obras Públicas, se esfuerza en culminar la edificación. En medio de esa iniciativa, surgen las figuras de varios arquitectos e ingenieros, nacionales y extranjeros, como Santamaría, Lelarge y Corredor Latorre, quienes, desde sus proyectos arquitectónicos, trataron de solventar el problema. A pesar de la aprobación, por parte del Ministerio, de dotar con una gran cúpula neobarroca la Cámara de Representantes, la materialización de la obra tampoco se realizó. En esta medida, el presente artículo trata de responder a la pregunta: ¿Cuáles fueron los cambios arquitectónicos y estilísticos, que se presentaron para la terminación del Palacio de Gobierno, de los poderes ejecutivo y legislativo de la Nación, entre 1912 y 1914? Para dar respuesta a este interrogante, se recurre al estudio cualitativo de las fuentes primarias, y algunas secundarias, que enmarcan el periodo en mención.
Materiales locales y su influencia en la morfología de la arquitectura
Authors: Montes Ponce Wendy Margarita , López Altamirano Otniel Josafat
Published: June 2022

La tecnología constructiva del siglo XX, tuvo un alto impacto en la morfología arquitectónica. Nuevas técnicas y sistemas constructivos constituyeron novedosas escalas, funciones, apariencias y símbolos, que estimularon el quehacer de los constructores del Movimiento Moderno Mexicano. A través del método deductivo, el objetivo fue demostrar el ensamble tecnológico que experimentó la Arquitectura, al emplear materiales, tanto industriales como locales. Y, con ello, demostrar que el producto de esta integración destacó edificios de notable dominio estético y utilitario. Los resultados concluyeron que las teorías de los arquitectos europeos y norteamericanos, gestaron las búsquedas estilísticas de los constructores mexicanos.
Contexts and Outcomes of Proxy Online Health Information Seeking: Mixed Studies Review With Framework Synthesis
Authors: El Sherif Reem , Pluye Pierre , Ibekwe Fidelia
Published: June 2022

Background

High-quality online health information (OHI) can reduce unnecessary visits to health professionals and improve health. One of the ways that people use OHI is to support others with health conditions through proxy OHI seeking. Members of a person’s social circle may help them overcome information-seeking barriers and illness challenges. There are several models on proxy information seeking. Yet, we know little about the use and outcomes of OHI on behalf of someone else.

Objective

The objectives of this paper are to explore and revise a framework on the context and outcomes of proxy OHI seeking

Methods

We conducted a mixed studies literature review integrating qualitative and quantitative evidence with thematic analysis of the findings of 28 studies, followed by framework synthesis incorporating the derived themes.

Results

We explored 4 main themes: (1) characteristics of proxy seekers, (2) context of proxy OHI seeking, (3) use of OHI to provide social support, and (4) outcomes of proxy OHI seeking. Our conceptual framework incorporates these themes and builds on previous work.

Conclusions

By better understanding how people use information together, information providers can adapt the information to meet all users’ needs.
Augmented Reality in Vascular and Endovascular Surgery: Scoping Review
Authors: Eves Joshua , Sudarsanam Abhilash , Shalhoub Joseph , Amiras Dimitri
Published: June 2022

Background

Technological advances have transformed vascular intervention in recent decades. In particular, improvements in imaging and data processing have allowed for the development of increasingly complex endovascular and hybrid interventions. Augmented reality (AR) is a subject of growing interest in surgery, with the potential to improve clinicians’ understanding of 3D anatomy and aid in the processing of real-time information. This study hopes to elucidate the potential impact of AR technology in the rapidly evolving fields of vascular and endovascular surgery.

Objective

The aim of this review is to summarize the fundamental concepts of AR technologies and conduct a scoping review of the impact of AR and mixed reality in vascular and endovascular surgery.

Methods

A systematic search of MEDLINE, Scopus, and Embase was performed in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. All studies written in English from inception until January 8, 2021, were included in the search. Combinations of the following keywords were used in the systematic search string: (“augmented reality” OR “hololens” OR “image overlay” OR “daqri” OR “magic leap” OR “immersive reality” OR “extended reality” OR “mixed reality” OR “head mounted display”) AND (“vascular surgery” OR “endovascular”). Studies were selected through a blinded process between 2 investigators (JE and AS) and assessed using data quality tools.

Results

AR technologies have had a number of applications in vascular and endovascular surgery. Most studies (22/32, 69%) used 3D imaging of computed tomography angiogram–derived images of vascular anatomy to augment clinicians’ anatomical understanding during procedures. A wide range of AR technologies were used, with heads up fusion imaging and AR head-mounted displays being the most commonly applied clinically. AR applications included guiding open, robotic, and endovascular surgery while minimizing dissection, improving procedural times, and reducing radiation and contrast exposure.

Conclusions

AR has shown promising developments in the field of vascular and endovascular surgery, with potential benefits to surgeons and patients alike. These include reductions in patient risk and operating times as well as in contrast and radiation exposure for radiological interventions. Further technological advances are required to overcome current limitations, including processing capacity and vascular deformation by instrumentation.
New views on the diagnosis and treatment of asthma in children
Authors: Marushko Yu.V. , Abaturov O.E. , Beketova G.V. , Berezenko V.S. , Pochynok T.V. , Churylina A.V.
Published: June 2022

The medical and social significance of the problem of asthma in childhood is extremely high. Global Initiative for Asthma (GINA) for the management of this disease has been known since 1993, based on the best information available to date. Global Initiative for Asthma has now been updated — the 2022 GINA revision. GINA 2022, in particular, considers the use of a single inhaler (inhaled glucocorticoid and formoterol) both to relieve symptoms and to provide basic therapy, emphasizes the importance of having a written plan of action for asthma. Today, children with asthma are thought to have a similar risk of contracting SARS-CoV-2 as children without asthma. In the context of a coronavirus pandemic, it is essential for asthma patients to continue their proper treatment with good control of clinical symptoms. A new aspect is that when COVID-19 is confirmed or suspected, the use of nebulizers should be avoided where possible due to the risk of transmitting the infection to other patients, family members and healthcare professionals. Although spirometry monitoring is indeed an important tool, in a pandemic it is recommended to limit it to patients in whom the results of this study may affect treatment. It is important to follow the recommendations of infection control, take precautions to reduce the risk of infection. Recent developments in asthma treatment strategies offer biological drugs as an alternative. Monoclonal antibodies, drugs targeting IgE-dependent mechanisms, IL-5, IL-4, IL-13, IL-33, anti-alarmin agents, etc. are considered. The focus of special attention in the optimal use of biological therapy for asthma is proper immune endotyping, development of appropriate biomarkers, determination of the main immunological mechanism for choosing the right targeted therapy. Much attention is now being paid to the molecular aspects of asthma. In-depth knowledge of allergenic structures has led to molecular component diagnostics, which has led to a better understanding of patient sensitization. Molecular-oriented diagnostics is used to determine the best approach to allergen-specific immunotherapy.
Design and Implementation of Job Recommendation Application ‘Jobs-3600’ for Job Seekers and Employers using Flutter
Authors: Vani Dr. B. , Kumar C. Naveen
Published: June 2022

Top companies are recruiting people online and during and after covid, they work from home. Most of the recruiting companies select people by conducting online test and interviews. Likewise, job seekers also choose jobs online through online portals. Job recruitments nowadays become a very important and fundamental process for industries like Information Technology, Government, and private sectors. The web-based applications caused a substantial impact on the recruitment process. The implementation of online recruiting platforms has become a primary recruitment channel in most companies. While companies established job positions on these portals, job-seeker uses them to publish their profiles. Online recruitment platforms accomplished clear advantages for both employers and job-seekers by reducing the recruitment time and advertisement cost. There are certain recommendation systems available on the internet to support the users in searching for their requirements that match their preferences. A wide range of smart phone applications is popular to deal with all sorts of user's requirements. To improve the e-recruiting functionality, many job recommendation systems have been proposed. This paper analyzes and develop a job application process and related issues for building personalized recommendation systems for job-seekers by an application called ‘JOBS-3600.
Autonomous Vehicle System
Authors: Verma Umang
Published: June 2022

Abstract: This paper is on a project an autonomous car is a vehicle capable of sensing its environment and operating without human involvement . A human passenger is not required to take control of then vehicle at any time , nor is a human passenger required to be present in the vehicle at all. Autonomous cars are the future smart cars anticipated to be driver less, efficient and crash avoiding ideal urban car of the future. In this regard the first challenge would be to customize and imbibe existing technology in conventional vehicle to translate them to a near expected autonomous car.
Gesture Controlled Virtual Mouse with the Support of Voice Assistant
Authors: Reddy Cherukupally Karunakar , Janjirala Suraj , Prakash Kevulothu Bhanu
Published: June 2022

Abstract: This work offers a cursor control system that utilises a web cam to capture human movements and a voice assistant to quickly traverse system controls. Using MediaPipe, the system will let the user to navigate the computer cursor with their hand motions. It will use various hand motions to conduct activities such as left click and dragging. It also allows you to choose numerous items, adjust the volume, and adjust the brightness. MediaPipe, OpenCV etc advanced libraries in python are used to build the system. A hand gesture and a voice assistant used to physically control all i/o operations. To recognise hand gestures and vocal instructions, the project employs cutting-edge machine learning and computer vision techniques, which operate effectively without the need for extra computer hardware. Hand gestures are a simple and natural way to communicate. Keywords: MediaPipe, Gesture Recognition, Voice Assistant, Machine Learning, Virtual Mouse
Self-Supervised Learning for Medical Imaging
Authors: Laxmaiah Dr. Bagam
Published: June 2022

Abstract: The role of deep learning is growing quite effectively. As the created models are producing promising accuracy and the early detection and mitigation of diseases is becoming quite easy. As a result, the deep learning algorithm is receiving a variety of interest nowadays for fixing several problems within side the area of scientific imaging. In ophthalmology, one instance is detecting disorder or anomalies by using photos and classifying them into diverse disorder types or severity levels. This sort of project has been finished the use of quite a few machine learning algorithms which have been optimized, in addition to theoretical and empirical approaches. Diabetic Retinopathy is such a disease where in early detection plays a severe role as it could result in imaginative and prescient loss. Diabetic Retinopathy disease recognition has been one of the active and challenging research areas in the field of image processing. Deep learning technique as well as hinders to work with disease recognition and find the accuracy of the model. To create a model in a supervised manner, we need a huge amount of dataset which is very costly. So, as to overcome this problem, we have implemented a self - supervised model for the detection of diabetic retinopathy which works with a very limited dataset. This model is implemented using one of the pretext/proxy task image rotations developed on Dense NET architecture. The model is fine-tuned with the various quantities of subsets of the original dataset and compared internally.
Solvent-Less Synthesis of Hybrid Molecules of 3-Formylchromones Catalyzed by Boric Acid
Authors: Mahajan Deepali
Published: June 2022

Abstract: In our effort to develop hybrid molecules, we conceived the synthesis of hydrazones from 3-formylchromone and carboxylic acid hydrazides in presence of boric acid as a green catalyst.
Gender Voice Recognition Using Machine Learning Algorithms
Authors: Bommaji Arun Pal
Published: June 2022

Abstract: Gender identification is one of the major problems in the area of signal processing. The system deals with finding the gender of a person using oral features. One of the most persnickety problems faced is feature selection from wide range of features, which is distinguishing factor in classifying the gender of aperson. The ideal of this design is to design a system that determines the speaker gender using the pitch of the speaker's voice. relating the gender from the plots of voice data set i.e., pitch, median, frequency etc. can be possible by using machine learning. In this design, we're trying to classify gender into male or female based on the data set containing varied attributes related to voice like pitch, frequency etc. The data set have features with explanation data points recorded samples of male and female voices. The data set can be trained with different machine learning algorithms. The proposed system can determine the gender of the speaker with real time test data a new result to discover the gender of the speaker using Fast Fourier Transform with Logistic Regression
Song Recommendation System using TF-IDF Vectorization and Sentimental Analysis
Authors: Chirasmayee B Venkata Sai
Published: June 2022

Abstract: In this project, we will build a machine learning model that recommends songs based on the songs already present in the playlist. We will implement Content based recommendation system. We will also create a web page in which the user can give the public playlist URI as input, and we will provide 5 to 20 song recommendations. Each song recommendation will be a link to the song and the song can be played on Spotify. Developers are now able to access millions of songs and obtain information like the song’s genre, the artist’s name, song’s release date, album name and so on through the Spotify API A developer can obtain can build Machine Learning models using the Spotify API using secret key and client id specific to the developer. We will be using spotipy package for Authentication of Spotify Developer credentials and for accessing the songs data. We will be using python scikit learn module for building Machine learning model. Flask module is used for web development. The final output will be a website deployed on local host
Android Food Diet Plan for Curing Diseases
Authors: M Vedhika
Published: June 2022

Abstract: In the healthcare industry, the patient's nutrition is a very important key factor in their treatment process. Every user has their own specific nutritional needs and requirements. An appropriate nutrition policy can help the patient's recovery process and possible symptoms. Food recommender systems are platforms that offer personalized suggestions of food diet plans to users. Moreover, there is a lack of usage of food recommendation systems in the healthcare sector. Multiple challenges in representing the domain of food and the patient's needs to make the user’s life easy in using this android application. The present project aims to develop a platform for the users to provide meals, based on their health conditions.