bluuebunny/crossref_metadata_2025 huggingface dataset:
Identification of GTF2I Polymorphisms as Potential Biomarkers for CKD in the Han Chinese Population
Authors: Lu Kevin , Chiu Kun-Yuan , Chen I-Chieh , Lin Guan-Cheng
Published: July 2024

Key Points

Genetic factors are key players in CKD, with two linked single-nucleotide polymorphisms in the GTF2I gene, associated with CKD susceptibility in the Taiwanese population.

Individuals with specific GTF2I genotypes (CT/TT for rs117026326 and CT/CC for rs73366469) show higher CKD prevalence and earlier onset.

Men with the specific genotypes of rs117026326 and rs73366469 face a heightened CKD risk compared with women, particularly at lower eGFR.

Background

CKD poses a global health challenge, but its molecular mechanisms are poorly understood. Genetic factors play a critical role, and phenome-wide association studies and genome-wide association studies shed light on CKD's genetic architecture, shared variants, and biological pathways.

Methods

Using data from the multicenter collaborative precision medicine cohort, we conducted a retrospective prospectively maintained cross-sectional study. Participants with comprehensive information and genotyping data were selected, and genome-wide association study and phenome-wide association study analyses were performed using the curated Taiwan Biobank version 2 array to identify CKD-associated genetic variants and explore their phenotypic associations.

Results

Among 58,091 volunteers, 8420 participants were enrolled. Individuals with CKD exhibited higher prevalence of metabolic, cardiovascular, autoimmune, and nephritic disorders. Genetic analysis unveiled two closely linked single-nucleotide polymorphisms, rs117026326 and rs73366469, both associated with GTF2I and CKD (r
2 = 0.64). Further examination revealed significant associations between these single-nucleotide polymorphisms and various kidney-related diseases. The CKD group showed a higher proportion of individuals with specific genotypes (CT/TT for rs117026326 and CT/CC for rs73366469), suggesting potential associations with CKD susceptibility (P < 0.001). Furthermore, individuals with these genotypes developed CKD at an earlier age. Multiple logistic regression confirmed the independent association of these genetic variants with CKD. Subgroup analysis based on eGFR demonstrated an increased risk of CKD among carriers of the rs117026326 CT/TT genotypes (odds ratio [OR], 1.15; 95% confidence interval [CI], 1.07 to 1.24; P < 0.001; OR, 1.32, 95% CI, 1.04 to 1.66; P = 0.02, respectively) and carriers of the rs73366469 CT/CC genotypes (OR, 1.13; 95% CI, 1.05 to 1.21; P < 0.001; OR, 1.31; 95% CI, 1.08 to 1.58; P = 0.0049, respectively). In addition, men had a higher CKD risk than women at lower eGFR levels (OR, 1.35; 95% CI, 1.13 to 1.61; P < 0.001).

Conclusions

Our study reveals important links between genetic variants GTF2I and susceptibility to CKD, advancing our understanding of CKD development in the Taiwanese population and suggesting potential for personalized prevention and management strategies. More research is needed to validate and explore these variants in diverse populations.
Digital competence of specialists in socio-economic, physics, and mathematics specialties, company managers in professional activities
Authors: Zhovnych Olesia , Bakhmat Nataliia , Kochubei Olena , Duchenko Anna , Ivashkevych Yevhen
Published: July 2024

This article explores the role of digitalization in enhancing personal and societal well-being. The role of digital competence, virtual and augmented reality tools, cloud technologies, robotics, 3D technologies, MOOC, e-learning, m-learning, flipped learning, Internet of Things (IoT), intermediate interval training, hybrid, mixed reality (MR), Machine Learning (ML), Artificial Intelligence (AI) in a person's professional life. The most effective principles of digitization are outlined, the services in demand for self-study and professional activities are identified, digital educational products and the most popular services, as well as free Web applications for joint professional work on the Internet, are identified, a matrix of their services, tools, and opportunities is compiled; the necessity of using messengers and cloud services has been proven. To form and develop the digital competence of specialists, the author's methodology was developed and introduced to the experimental group using digital applications, services, digital tools, etc. in human life. The qualitative analysis of the effectiveness of the development of the digital competence of specialists was confirmed by the quantitative analysis of positive changes in all blocks. Methodological recommendations have been developed for the development of the digital competence of specialists and the optimal practical use of digital technologies in a person's professional activity.
Pentingnya Merumuskan Visi dan Misi Pada Lembaga Pendidikan
Authors: Aulia Yenni , Ose Fitria , Idris Idris , Rusdinal Rusdinal , Anisah Anisah
Published: July 2024

This research aims to summarize and describe the importance of formulating a vision and mission in educational institutions. The method used in writing this scientific article is by using the library research method. In an educational institution, the vision and mission are very important. The vision and mission of an educational institution is the foundation that serves as a guide for all stakeholders, from managers, teaching staff, to students. The vision reflects the image of the future desired by the institution, while the mission describes the concrete steps that will be taken to realize that vision. Therefore, the success of an organization is largely determined by the process of formulating the vision and mission of the educational institution. Formulating a vision and mission also plays a key role in increasing the accountability of educational institutions. By setting specific goals in the mission, institutions have a basis for measuring their performance and achievements. This helps create high standards of quality and accountability, which in turn contributes to improving the overall quality of education. Schools must carry out their duties well as educational institutions whose mission is to achieve educational goals.  In recognizing its role as an educational institution, schools must be managed well to achieve the formulated educational goals optimally without hesitation
Peran Teknologi Dalam Mengatasi Krisis Pendidikan di Daerah Terpencil
Authors: Firdaus Khairul , Ritonga Mahyudin
Published: July 2024

The education crisis in remote areas in Indonesia is one of the main challenges hampering equal distribution of education quality. This article examines the role of technology in overcoming various obstacles faced by the education sector in these regions. Education in remote areas, from elementary to senior level, really needs the right technology so that it can develop in line with today's times. Information and communications technology (ICT) offers innovative solutions to improve access and quality of education, through e-learning, educational applications and other digital tools. However, the application of technology in remote areas faces various obstacles, including limited infrastructure, uneven internet access, and low digital literacy among teachers and students. The research method uses literature studies from various valid reading sources. This article offers various solutions and initiatives and strategies that have been implemented to overcome this challenge, such as training programs for teachers, improving digital infrastructure, and collaboration between the government and the private sector. With a holistic and integrated approach, technology can be the key to overcoming the education crisis in remote areas and encouraging better educational equality throughout Indonesia.
Модель ринку цифрових криптовалют у рамках диференціальної гри якості
Authors: Малюков Володимир Павлович , Малюкова Інна Володимирівна
Published: July 2024

Стаття присвячена розробці неперервної багатофакторної моделі ринку цифрових криптовалют (ЦКВ) у рамках схеми диференціальної гри якості. Розглянуто ігрову модель торговельної сесії на ринку ЦКВ. Показано, що керованість процесу на торговельній сесії може бути описана з погляду ігрового підходу на основі рішення системи білінійних диференціальних ігор, які дають змогу адекватно описати процес розподілу обсягів цифрових криптовалют. Такий підхід не відкидає реалізацій гри з боку загального колективного контрагента. Він дозволяє розглянути випадки, що призводять до нестабільності співвідношення фінансових ресурсів гравців, наприклад, ЦКВ1 до ЦКВ2 і навпаки. Новизна моделі полягає у тому, що вона відрізняється від існуючих підходів рішенням білінійної диференціальної гри якості з кількома термінальними поверхнями. Знайдено рішення нової білінійної диференціальної гри якості з залежними рухами, що адекватно описує процедуру купівлі-продажу ЦКВ на ринку криптовалют. Проілюстровано результати обчислювального експерименту, під час якого враховувалися різні співвідношення параметрів, що описують процес купівлі-продажу ЦКВ. Отримані результати можуть виявитися корисними для запобігання ситуаціям курсової нестабільності на ринку інвестицій у ЦКВ. Також їх можна використовувати як деякі рекомендації щодо вибору керуючих впливів для підтримки курсової стабільності на ринку інвестування у ЦКВ на рівні великих банківських гравців. Запропонований підхід дав можливість конструктивного знаходження стратегій валютної стабільності на ринку ЦКВ. Він полягає в адекватності розробленої моделі неперервному процесу купівлі-продажу ЦКВ, що дозволило використовувати інструментарій білінійних диференціальних ігор якості для знаходження стратегій гравців. Наведено розрахунки, в яких розглянуто різні співвідношення параметрів, що характеризують процеси на ринку ЦКВ. Отримані результати дозволяють учасникам цього ринку мати інструменти, які підтримуватимуть валютну стабільність на ринках традиційних валют і ЦКВ. Запропонована модель може бути використана у програмних продуктах, що застосовуються на торгових майданчиках, призначених для проведення угод по ЦКВ.
Artificial intelligence in management problems
Authors: Voronin Albert , Savchenko Alina
Published: July 2024

The problems of optimization of a controlled object pursuing several goals are considered. A model of multi-criteria optimization has been obtained, which allows the controlled object to realize all the goals set in the entire range of possible situations without the direct participation of a person. A systematic approach to the problem of vector optimization made it possible to combine models of individual trade-off schemes into a single integral structure that adapts to the situation of making a multi-criteria decision. The advantage of the concept of a non-linear trade-off scheme is the possibility of making a multi-criteria decision formally, which is a hallmark of artificial intelligence. The apparatus of the nonlinear trade-off scheme, developed as a formalized tool for studying management systems with conflicting criteria, allows the artificial intelligence system to solve practically multi-criteria problems of a wide class. Artificial intelligence systems are created in order to replace a person as a decision maker in this or that situation. AI systems such as robots, decision support systems, neural networks, etc. operate in conditions that a person considers unfavorable for himself. Thus, a demining robot operates in an environment that is dangerous for a sapper. Decision support systems are usually used in conditions of time pressure or in aggressive environments. Neural network classifiers process volumes of information that exceed the capabilities of a human operator, etc. Replacing a person with an AI system requires the formalization of both the formulation and the process of solving the problem. Subjective factors should be excluded from the solution algorithm. A special place among such systems is occupied by those which functioning is evaluated by a set of conflicting quality criteria. When solving a specific problem of vector optimization, the decision maker creates his own model of the objective function (utility function) in accordance with his preferences.
Empathy Map Gen Z Towards Healthy Food: A Foodpreneur Design Strategy
Authors: Ulita Novena , Kartanegara Ath Thariq , Salsabila Jihan , Saleh Arifin , Queen Zabenaso
Published: July 2024

Healthy eating behavior is becoming increasingly prevalent in Indonesia, especially after the COVID-19 outbreak from 2020-2022, which highlighted the importance of diet for immunity. Generation Z, being a significant part of the Indonesian population, presents an opportunity for targeted public health promotions. This study aims to explore Generation Z attitudes towards healthy food to develop an effective Foodpreneur design strategy. Using a qualitative approach, data were collected through interviews and literature studies involving 29 Gen Z participants from various campuses. The research applied the design thinking method and the empathy map to derive a comprehensive strategy. The results revealed that while Gen Z acknowledges the importance of healthy eating for a balanced lifestyle, they face barriers such as economic constraints, taste preferences, and accessibility. However, there is a clear enthusiasm for promoting local and sustainable food practices. The findings suggest that an effective Foodpreneur design strategy should emphasize educating Gen Z on the benefits of local and healthy food, creating engaging and relatable promotional content, and leveraging social media to enhance awareness and accessibility. This approach can foster a culture of health consciousness and support local economies, aligning with Gen Z values and behaviors.
Assessing predictability of hydrological processes (on the example of frozen soil water content dynamics)
Authors: Gelfan А.N.
Published: July 2024

A method has been developed for assessing the limits of predictability of the frozen soil water content (according to observations at the Nizhnedevitskaya water balance station). The method is based on the analysis of the convergence of a given probabilistic measure (the variance of the calculated soil water content at a given date) to its stable value. The soil water content was simulated by the physically based model of heat and water transfer in a frozen soil column during a autumn-winter seasons. To assess variability of the modelled soil water content at a given date, the boundary meteorological conditions for the autumn-winter period were simulated by the Monte Carlo procedure using a stochastic weather generator. The initial conditions were assigned as the constant soil temperature and soil moisture values over the 1-meter soil column. The predictability of the soil water content in the one-meter layer of the studied soils has occurred to be about 1.5 months; it means that for the forest-steppe conditions, the soil water content before the beginning of soil freezing cannot serve as an indicator of soil water content before spring. Numerical experiments have shown that the soil water content predictability: (1) grows with an increase in the thickness of the considered soil layer and its depth; (2) decreases for coarser soils as compared to finely dispersed soils; (3) is more sensitive to changes in the soil texture than to changes in the climatic norms of precipitation and air temperature.
HIGHLY RELIABLE "ETERNAL" STORAGE OF INFORMATION: IDEOLOGICAL FORMULATIONS
Authors: СТРОЕВ С.А.
Published: July 2024

В статье рассматриваются различные варианты «идеологического» оформления проекта долгосрочного высоконадёжного хранения данных. Версия «Послания человечества Вселенной» отвечает романтическому и оптимистическому взгляду на будущее человечества как единого целого в духе научной фантастики и веры в дальнейшие перспективы научно-технического прогресса и миссии освоения и колонизации человечеством Космоса. Версия «азимовского Основания» или «Хранилища Судного дня» отвечает представлениям о глубоком кризисе современной цивилизации, зашедшей в тупик своего развития, о вероятном в обозримом будущем глубоком цивилизационном регрессе и наступлении своего рода новых «Тёмных веков». Версия суверенных национальных проектов соответствует представлению о конце эпохи глобализации и о возвращении к многополярному миру, разделённому на конкурирующие друг с другом цивилизации, организованные в виде неоимперских геополитических субъектов. При этом за разными идеологическими оформлениями, обращёнными к носителям разных мировоззрений, картин мира, ценностных установок и образов будущего, с точки зрения конкретных практических действий, технических и организационных решений фактически стоит один и тот же требующий реализации проект. Статья является частью серии публикаций, посвящённых проекту «Ковчег», и прямым продолжением статьи «Высоконадёжное «вечное» хранение информации: концепция и практические реализации», публикуется впервые.

The article discusses various options for the "ideological" design of a long-term highly reliable data storage project. The version of the "Message of Humanity to the Universe" corresponds to a romantic and optimistic view of the future of humanity as a whole in the spirit of science fiction and faith in the future prospects of scientific and technological progress and the mission of space exploration and colonization by mankind. The version of the "Asimov Foundation" or "Doomsday Vault" corresponds to the ideas of a deep crisis of modern civilization, which has reached a dead end in its development, of a deep civilizational regression likely in the foreseeable future and the onset of a kind of new "Dark Ages". The version of sovereign national projects corresponds to the idea of the end of the era of globalization and the return to a multipolar world divided into competing civilizations organized in the form of neo-imperial geopolitical entities. At the same time, behind the different ideological designs addressed to the bearers of different worldviews, worldviews, values and images of the future, from the point of view of concrete practical actions, technical and organizational solutions, there is actually the same project requiring implementation. The article is part of a series of publications dedicated to the Ark project and a direct continuation of the article "Highly Reliable"eternal" information Storage: concept and Practical implementations", published for the first time.
SMALL FORMS OF MANAGEMENT IN THE AGRICULTURAL SECTOR OF THE REGION: CURRENT STATE, PROBLEMS AND PROSPECTS OF DEVELOPMENT
Authors: ЗАЙЦЕВА Е.В. , ЖУПЛЕЙ И.В.
Published: July 2024

В статье рассмотрено современное состояние и выявлены общие тенденции развития малых форм хозяйствования (МФХ) в аграрном секторе Костромской области, а так же определена их роль в развитии сельского хозяйства региона в условиях реализации финансовых мер государственной поддержки, определены факторы, сдерживающие развитие указанного аграрного сегмента и представлены перспективные направления его развития. Новизна исследования заключается в выявлении взаимосвязи развития малых форм хозяйствования в сельском хозяйстве и грантовой поддержки фермеров в рамках программ акселерации. Результаты исследования отражают наличие общих тенденций развития малых форм хозяйствования в аграрном секторе на региональном уровне, связанных с особенностями финансовой поддержки по программам акселерации. Полученные результаты могут использоваться при формировании системы мер государственной поддержки малых форм хозяйствования в аграрном секторе Костромской области.

The article examines the current state and identifies general trends in the development of small business entities (MFCs) in the agricultural sector of the Kostroma region, as well as defines their role in the development of agriculture in the region in the context of the implementation of financial measures of state support, identifies factors constraining the development of this agricultural segment and presents promising directions for its development. The novelty of the study is to identify the relationship between the development of small forms of farming in agriculture and grant support to farmers within the framework of acceleration programs. The results of the study reflect the presence of general trends in the development of small businesses in the agricultural sector at the regional level, related to the specifics of financial support for acceleration programs. The results obtained can be used in the formation of a system of state support measures for small businesses in the agricultural sector of the Kostroma region.
COMPARATIVE INDICATORS OF FAMILY BUSINESS AND OTHER FORMS OF ENTREPRENEURSHIP
Authors: МАХНЕНКО С.И . , ВАСЮК А.И.
Published: July 2024

В данной статье рассматривается семейный бизнес как одна из форм предпринимательской деятельности, производится сравнение с иными формами бизнеса. Рассматриваются цели и мотивы семейных предприятий, сходства и различия между семейным и несемейным бизнесом, а также выводится гипотеза относительно подхода семейного бизнеса к цели максимизации прибыли. Анализируется мотивация семейных предприятий, их ключевые особенности, а также тенденция данных предприятий к интернационализации.

This article examines family business as one of the forms of entrepreneurial activity, and compares it with other forms of business. The goals and motives of family enterprises, similarities and differences between family and non-family businesses are considered, and a hypothesis is derived regarding the approach of family business to the goal of maximizing profits. The motivation of family enterprises, their key features, as well as the tendency of these enterprises to internationalization are analyzed.
Sex education as part of the valeological discipline "Health Pedagogy"
Authors: Shevchenko A.S. ,   Kharkiv Regional Institute of Public Health Services, Kharkiv, Ukraine, Aliieva T.D. ,   Kharkiv National Medical University, Kharkiv, Ukraine,   Kharkiv Regional Institute of Public Health Services, Kharkiv, Ukraine; Kharkiv National Medical University, Kharkiv, Ukraine
Published: July 2024

The valeological discipline "Health Pedagogy" was developed and implemented in the educational process of Ukrainian higher non-medical education institutions in 2019. The discipline is intended for the formation of valeological competence, which consists in the ability to lead a healthy lifestyle, practice safe behavior and provide emergency assistance in critical situations. The medical component of the topic of sex education and family planning of the valeological discipline "Health Pedagogy" includes issues of safe and unsafe sex, fertility, prevention of unwanted pregnancies, infection with sexually transmitted diseases, abortion, anatomy and physiology of male and female genital organs, physiology of intercourse, contraception, normal and pathological pregnancy, childbirth, genetic aspects of fertilization and development of the embryo and fetus) and ethical issues of its teaching, which corresponds to the recommendations of the Ministry of Health of Ukraine and a number of authoritative international organizations. Retrospective evaluation of archival learning materials (tests and questionnaires) for the topic "Sex education and family planning" of valeological disciplines "Basics of Medical Knowledge and Health-Saving" and "Health Pedagogy" of 180 students of three Kharkiv non-medical higher education institutions, bachelor's and master's degrees, who studied during 2004–2024 and formed valeological competence at a high level according to the quartile evaluation system (Q4[75÷100]%). It was found that 148 (82.2%) students formed the component of competence related to sex education and family planning at a high level (Q4[75÷100]%), 32 (17.8%) – at the average level (Q3[50÷75]%) (p<0.05%). It was concluded that the content, form of teaching, medical and psychological-pedagogical components of the topic on sex education and family planning of the valeological discipline "Health Pedagogy" allow forming the appropriate component of valeological competence at a high level. Keywords: valeological education, valeological competence, qualimetry, abortion, contraception, obstetrics and gynecology.
Quantitative assessment of the occurrence of asymmetric and symmetrical maxillary constriction and related pathological conditions
Authors: Khumgaeva Kh.R. , Israfilova A.F. , Delaeva Kh.U. , Mirokhanien Sh.E.
Published: July 2024

Quantitative assessment of the occurrence of asymmetric and symmetrical maxillary constriction and related pathological conditions
Features of planning and carrying out dental implantation in patients with acromegaly
Authors: Efendiev E.M. , Amhadova M.A. , Ilovayskaya I.A. , Navruzov R.A.
Published: July 2024

The article, based on literature data, lists the features needed to be taken into account by dentists when diagnosing and treating patients with acromegaly who apply for dental implantation and subsequent prosthetics.
A clinical case is presented of a patient, who underwent dental implantation with an unsuccessful result without taking into account the presence of acromegaly. It is shown how subsequent comprehensive treatment with an endocrinological diagnosis of somatotropinoma positively affected patient’s treatment.
Conclusions were drawn with recommendations, taking which into account will significantly increase the survival rate of dental implantation for patients with acromegaly.
THE IMPACT OF FINANCIAL INCLUSION OF MIGRANTS ON ECONOMIC GROWTH
Authors: CHERNOBAY Liana , MALIBRODA Sviatoslav
Published: July 2024

Introduction. In the global economy, people migrate between regions or countries in searching better life. The migration is beneficial for both the country of origin and the host country. Economic benefits consist in sending money by migrants’ home through various remittance channels such as commercial banks, cash money market, electronic transfers. That is why the lack of access to regular financial services is a significant challenge to the economic independence of migrants and their self-sufficiency. As a result, international humanitarian organizations are increasingly promoting the financial integration of refugees, their empowerment, integration into the host economy, promoting self-sufficiency and financial inclusion. This actualizes the scientific research of economic growth and financial inclusion of migrants, because a passive response to the problem threatens the harmonious development of regions that are actively involved into migration processes.

The purpose of the article is the research with focus to analyze the constituent elements of economic growth in the conditions of migration flows increasing and to outline directions for strengthening the financial inclusion of migrants.

Results. The constituent elements of economic growth in the conditions of financial inclusion of migrants were considered. It was provided a taxonomic analysis of the theories of migration, its motivation and attraction factors. The Ukrainian economy was analyzed under of migration flows growing, estimated the pace of its recovery and reconstruction due to international aid and remittances from migrants. It was evaluated the financial integration and financial inclusion of migrants in terms of the availability of basic financial services. The factors affecting the financial inclusion of migrants and preventing the receipt of financial services were identified. It was outlined the directions for strengthening the financial inclusion of migrants.

Prospects. The subject of further scientific research is the research of the level of digital financial inclusion of migrants, which can become an effective tool for overcoming socio-economic problems and stimulating economic development.
Investigating the mechanism of SiO2/4H-SiC interface traps passivation by boron incorporation through FT-IR analysis of near-interface SiO2
Authors: Wang Runze , Noguchi Munetaka , Hino Shiro , Kita Koji
Published: July 2024

This study investigates the effect of boron-incorporation (B-incorp) on SiO2 properties near the SiO2/4H-SiC interface by Fourier transforms infrared spectroscopy with attenuated total reflection mode. We focus on the range of Si–O–Si asymmetric stretching vibrations, whereas B-incorp samples exhibited a different peak shift trend compared to the thermal oxidized samples. The observed peak shift, corroborated by the calculated spectral simulation, suggests a reduction in oxygen deficiency near the interface for B-incorp samples. This suggests a potential link between B-incorp and the passivation of traps near the interface, possibly through its influence on SiO2 stoichiometry.
Climate Change: Global and Regional Challenges
Authors: Bozó László
Published: July 2024

Components of the Earth System – atmosphere, oceans,land and ice cover, biosphere – interact with each otheron several different scales. This paper presents the mostimportant recent environmental changes caused mainlyby anthropogenic activity. The key role of the water cycleis emphasized on both global and regional scales, having dominant effects on the state of the environment and any human activities.
Traducendo Brecht. Il carteggio tra Cesare Cases e Gabriele Mucchi (1985-1994)
Authors: Martini Magda
Published: July 2024

The correspondence between Cesare Cases and the artist Gabriele Mucchi bears witness to a genuine confrontation on several fronts between two great 20th century Italian intellectuals. The occasion for the epistolary exchange, in the mid-1980s, was a close collaboration for the publication of a collection of Brecht’s poems chosen and translated by Mucchi, for which Cases wrote the preface. But the confrontation on topics such as metrics, poetics and politics laid the foundations for a sincere mutual esteem and the birth of an ironic friendship. Although in their differing moods, Cases and Mucchi at last found themselves commenting on the fall of the Berlin Wall and the transformations this brought about in the German Democratic Republic and in the Italian political and intellectual scene.
Analiza rozłożenia praw i obowiązków we wspólnotach w świetle złożonej korelacji kompensującej
Authors: Stoiński Andrzej
Published: July 2024

The article examines the distribution of rights and duties of justice among entities of unequal status in their mutual relations in communities. The analyses are performed from the perspective of complex compensatory correlation, which is a dicaiological modification of the Hohfeldian legal rights correlation model. The first thesis of the article asserts that alignment of the rights and duties of entities in accordance with the compensatory correlation scheme is a necessary condition for justice in community relations. The second thesis states that an increase in the welfarist positive rights of some citizens is accompanied by an increase in the rights of the government. These proposals are juxtaposed with the image of rights and duties within the family and political community. In the case of entities in family relationships and in some political community relations, one can observe a balance between the rights and duties assigned to them. However, there are also interactions in which some entities have double duties and others have double rights, and therefore, we cannot find there a pattern suitable for a complex compensatory correlation. In such cases, there are deficiencies in the sphere of justice.
The Effects of Oral Progestagen Administration on the Fertility of Synchronized Goats During the Breeding Season
Authors: Çetin Nebi , Kuru Mushap , Koca Davut , Eşki Funda , Uslu Barış Atalay , Sendag Sait , Wehrend Axel
Published: July 2024

The objective of this study was to assess the impact of oral progesterone (altrenogest) administered after mating on fertility in goats synchronized during the breeding season. A total of 47 Hair goats were included in the study. A progesterone-impregnated intravaginal sponges were administered for 12 days. On day 10 of intravaginal sponge administration, 480 IU pregnant mare's serum gonadotropin (PMSG) and 0.075 mg cloprostenol were injected intramuscularly to the goats. Animals were exposed to bucks for 12 hours after detection of estrus by the foraging buck. The goats were randomly assigned to two distinct groups: Group 1 (G1, n=23) and Group 2 (G2, n=24). G1 goats were orally administrated 4.4 mg of altrenogest per day for 30 days after mating. G2 goats served as controls. Pregnancy examinations were performed by transrectal ultrasonography on the 30th and 42nd days after mating. Blood samples were taken from one day after mating to 30 days (3-day intervals). Statistical analysis comparing G1 and G2 revealed no significant differences between the groups regarding progesterone concentrations, conception rate, pregnancy rate, lambing rate, multiple birth rate, fecundity, and litter size (p>0.05). In conclusion, this study revealed that oral progesterone use had no impact on fertility parameters. Moreover, further research is warranted to explore the efficacy of various oral progesterone analogs.
Review of Key Metrics for Analysing the Delivery Quality of Healthcare Providers
Authors: Sandar Nay Myo , Tripura Shuvra
Published: July 2024

This research study explores the essential role of healthcare providers in delivering quality care to individuals and communities. The healthcare system relies on a diverse range of providers with different specialties and roles including those in primary care, secondary care, tertiary care, and quaternary care. The study emphasizes the importance of collaborative efforts among these providers to deliver high-quality, comprehensive healthcare services. Additionally, the article discusses the significance of healthcare quality dashboards as crucial tools for tracking and enhancing patient care outcomes. These dashboards visually represent important performance indicators, facilitate pattern recognition, evaluate progress against metrics, and support data-driven decision-making for healthcare practitioners.
BIOCIDE ADDITIVES (REVIEW)
Authors: Latyshevich Irina A. ,   Institute of Physical-Organic Chemistry of the National Academy of Sciences of Belarus, Hapankova Alena I. , Kozlov Nikolay G. , Hliavitskaya Tatiana A. ,   Institute of Physical-Organic Chemistry of the National Academy of Sciences of Belarus,   Institute of Physical-Organic Chemistry of the National Academy of Sciences of Belarus,   Institute of Physical-Organic Chemistry of the National Academy of Sciences of Belarus
Published: July 2024

In the modern world, the problem of studying the biodamage of various materials and structures is extremely relevant, because these processes progress actively every year. Biocorrosion is caused by various living organisms - from bacteria and fungi to plants and animals. However, microorganisms cause the main damage. The degree of their destructive impact is determined by physical, chemical, biological and other factors. The damage is most intense at high humidity, relatively high temperatures, and an abundance of dust and organic pollutants. Under favorable conditions for the development of microorganisms, destructive processes begin with their transfer to the surface of products, adsorption, formation and growth of microcolonies due to the proliferation of hyphae and spores, accompanied by the release of metabolic products, their accumulation and corrosive effects. Considering the significant damage caused by biological destruction to various materials, the threat to human health and life, there is a major problem of finding ways to increase their biological resistance and durability. One of the options for preventing the negative impact of microorganisms on various materials is the use of biocidal additives. Despite the large volume of scientific research and publications on the topic in question, this problem remains unresolved until now. The paper shows the results of research in the development and application of biocidal additives for various materials over the past five years by analyzing scientific, technical and patent information.
Effects of Music Therapy in Awaken Memories and Boosting Brain Activities on Patients Suffering From Alzheimer and Dementia
Authors: - Nawal Dawsh , - Afrah Altamimi , - Amal Aladwani , - Sharqiah Alanazi
Published: July 2024

Alzheimer and Dementia represent some of the existing and most pressing global health problems based on the rising dominance rate and the constraint of medical implications (Fang, Ye, Huangfu & Calimag, 2017). Alzheimer as one of the most experienced types of dementia illness is usually characterized by advancing cognitive impairment and memory loss. This can result in severe effects by forcing the affected persons to lose their general capabilities to accomplish some given responsibilities. Alzheimer is categorized as thaw most severe health problem of the modern society for humanity. With the rising aging populace, the general number of individuals suffering from Alzheimer and other different types of Dementia is growing in a rather drastic way. Based on a report released in 2013 it has been established that the number of those affected by Alzheimer alone globally is beyond 35 million a level that is projected to exceed by three times by the year 2050 (Fang, Ye, Huangfu & Calimag, 2017).
Despite the fact that the issue has emerged to be a major one it is rather saddening that there lack effective drugs for the ailment. It cannot be denied that Alzheimer and other Dementias have proved to be a major challenge not only based on the lack of effective clinical intervention strategies but also based on its physical, psychological and financial effects. To begin with, Alzheimer is psychologically demanding both for the patients as well as those individuals that surround the patients which might incorporate friends and families (Fang, Ye, Huangfu & Calimag, 2017). In that when an individual suffers from memory loss and minimal brain activity this implies that they can no longer be able to accomplish their daily operations as they were used to which thus implies that they have completely lost independence.
Unveiling the Dark Side : A Trip of Drug Induced Hyperpigmentation Cases
Authors: - Dr. Vyjayanthi
Published: July 2024

Drug induced hyperpigmentation is a condition characterized by the darkening of skin due to the administration of certain medications. This phenomenon can affect individuals of all ages and skin types, presenting a significant concern due to its potential impact on a patients’s quality of life and psychological well being. Many drugs produces cutaneous pigmentation as adverse side effect on withdrawal. Here, we report 3 cases of drug induced pigmentation caused by hydroxycholorquine, clofazimine and Iron sucrose injection
A Stage Proposal for Hamlet’s Politicised Body: Requiem for a Woman Born to be King
Authors: Nedelea Patricia
Published: July 2024

This article is addressed to stage performers and directors, offering alternative ways of thinking and interpreting a role while using Shakespeare’s Hamlet as a pretext - both the play and the lead. In my gendeconstructed and genreconstructed vision, the main character’s female physical body is forcefully substituted by the politicised body (male, royal, learned) imposed by societal expectations. Its practical utopian aim is to offer female actors new roles and possibilities, new visions of dusty classical roles. My “personal and political” standpoint is to advocate for more female roles and, implicitly, more jobs for women in theatres. Most classic plays predominantly feature male roles, which are forever reiterated onstage. However, in the following article’s view, the male characters can be challenged and transformed into female characters, the character’s gender, going beyond the character’s exterior looks – which would easily be obtained using travesty. The following analysis proves that changing the gender of a character will generate a vital change for the whole play. It will function as a de-peripheralized stage catalyst, forcing the sexist heteronormative classical plays to actually work for women, for female actors. This transformation will also give the play a Camp aesthetic, challenging and ultimately changing the conventional genre of the play.
Another You – Virtual Embodiment Creative Practice
Authors: Făcăeru Ciprian
Published: July 2024

This paper delves into the intricate creative process behind the “In Search of the Lost Body” virtual embodiment installation, part of Adina Pintilie’s multi- platform project “You Are Another Me—A Cathedral of the Body,” exhibited at the 59th International Art Exhibition—La Biennale di Venezia in 20221. It investigates the foundation of this multi-sensory installation’s synergistic integration of art and technology through the lens of the author’s roles as immersive media artist, experiential designer, and researcher of the contemporary art project. By unravelling the project’s journey from inception to exhibition, this paper demystifies the methods and processes implemented to create a virtual immersive art installation. At the same time, it provides an in-depth viewpoint on the transformational potential of virtual embodiment in redefining audience engagement, as evidenced by enhanced emotional responses and a deeper connection captured by participant feedback and observational studies. By addressing the challenges and innovations in the field, the article reveals the installation’s pioneering contributions to emergent digital art forms. It also reveals the multimodal sensory elements that intensify audience immersion and deepen the connection to the artwork’s thematic core. This investigation not only focuses on the aesthetic and technical aspects but also critically assesses its impact on reshaping audience perceptions and emotional involvement while exploring the transformative influence of virtual embodiment and its implications for expanding our comprehension of the human experience.
Molecular and cellular processes underlying Unverricht-Lundborg disease—prospects for early interventions and a cure
Authors: Žerovnik Eva
Published: July 2024

A short overview of the main features of progressive myoclonus epilepsies (PMEs), such as Lafora disease (LD), neuronal ceroid lipofuscinoses (NCLs), and myoclonus epilepsy with ragged-red fibers (MERRF) is given. The stress of this review paper is put on one of the PME’s, the Unverricht-Lundborg disease (ULD)—EPM1, which is caused by mutations in the human cystatin B gene (stefin B is an alternative protein’s name). However, different other genes/proteins were found mutated in patients presenting with EPM1-like symptoms. By understanding their function and pathophysiological roles, further insights into the underlying processes of EPM1 can be obtained. On a broader scale, common pathophysiological mechanisms exist between ULD, LD and NCLs, such as, reactive glia, synaptic remodeling, neuronal hyperexcitability, impairements in the lysosomal/endocytosis system, cytoskeletal functions, and mitochondria. Oxidative stress is also in common. By understanding the underlying molecular and cellular processes, early interventions, better therapies and eventually, by using modern stem cell, gene editing or replacement methods, a cure can be expected.
Transformational Leadership in Local Heritage Area Development (Case Studies in Medan Kesawan Area and Semarang Kota Lama)
Authors: Thamrin Muhammad Husni , Nasution Faiz Albar , Setiawan Yuliyanto Budi , Indainanto Yofiendi Indah
Published: July 2024

Sustainable development of local heritage areas can boost the economy and people’s standard of living. This research describes transformational leadership contributing to the sustainable development of local heritage in Medan City and Semarang City. This research uses a descriptive qualitative method. Data were obtained by observation, documentation, and interviews. Data analysis techniques were used by reducing data, presenting, and making conclusions. The results showed that transformational leadership contributes to the development of sustainable development of the Kesawan area in Medan City and the Kota Lama area in Semarang City, which is seen based on four characteristics of transformational leadership, namely: idealistic leadership, inspirational motivation, intellectual stimulation, and individualized consideration. Medan City has potential as the condition of the building is still very good in the Kesawan area. The obstacles are the legal aspects where many illegal buildings are built and the need for coordination between the government and non-government organizations. In Semarang City, the driving factor is more influenced by the government’s and stakeholders’ readiness and awareness regarding the Kota Lama Area as a cultural heritage. Barriers regarding the level of security and bureaucracy over the massive turnover of members who have the authority to continue the management of the Kota Lama. From the Implementation results, Medan City is still in revitalization and infrastructure development, so the results must be concrete and specific. On the other hand, the Semarang City Government has provided concrete and specific contributions, especially in economic and socio-cultural aspects.
Estará no passado a resposta do direito à mudança do clima na Amazônia? considerações portuguesa sobre o regime brasileiro de arrendamento rural e sua reforma
Authors: Masseno Manuel David
Published: July 2024

Objetivos: Assumindo o Direito como uma tecnologia social, inclusive quanto aos contratos privados, a presente pesquisa pretende estudar as vias de adaptar os regimes aplicáveis atualmente ao arrendamento rural no Brasil aos desafios da Mudança do Clima, em especial em regiões mais vulneráveis, como a Amazônia.
Metodologia: Foram sobretudo seguidos métodos jurídicos consolidados, como o analítico, o histórico e o comparativo, com vista a identificar as alternativas mais viáveis, desde as lições aprendidas com soluções legislativas já colocadas em prática, tanto no Brasil quanto em Portugal.
Resultados: A pesquisa mostra como, sem alterações profundas do Ordenamento brasileiro relativo aos contratos agrários, ou até apenas por iniciativa das partes, é possível efetivar uma atribuição mais adequada dos riscos resultantes da Mudança do Clima.
Contribuições: Esta pesquisa abre caminhos novos, ao ir além das Políticas Públicas na adaptação das atividades económicas à Mudança do Clima, desde uma perspectiva rigorosa de Direito Privado, tendo por base as Fontes históricas do Direito Brasileiro.
Somut Olmayan Kültürel Miras Bağlamında Muğla Mutfak Kültürü ve Sözlüğü Menteşe
Authors: Zağralı Çakır Egem , Bekar Aydan , Kılıç Burhan
Published: July 2024

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