bluuebunny/crossref_metadata_2025 huggingface dataset:
Epigallocatechin Gallate (EGCG) – A Novel Covalent NF- κB Inhibitor: Structural and Molecular Characterization
Authors:   Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India, AT Reddy , SP Lakshmi ,   Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India, N.Ch Varadacharyulu ,   Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India, LD Kodidhela ,   Department of Biochemistry, Sri Krishnadevaraya University, Anantapur, Andhra Pradesh, India
Published: July 2021

Tea contains antioxidant catechins thought to exert health-promoting protective effects against conditions involving chronic inflammation, such as cardiovascular diseases. The most abundant catechin in tea is Epigallocatechin Gallate (EGCG), thought to be a key contributor to tea’s health-promoting actions. EGCG exerts protective cardiovascular effects via its antioxidant, antiinflammatory, hypolipidemic, anti-thrombogenic, and anti-hypertensive actions. Because EGCG inhibits the strong proinflammatory gene-inducing transcription factor NF-κB, we analyzed the chemical and molecular details of the mechanism by which EGCG mediates NF-κB inhibition. We quantified and mapped key parameters of its chemical reactivity including its electrophilic Fukui ƒ+ function, in silico covalent binding, and identified its frontier Molecular Orbitals (MOs) and nucleophilic susceptibility. These physical and chemical reactivity parameters revealed that the bond-forming MOs are distributed on the B ring of the EGCG oxidized state with nucleophilic susceptibility, and that this B ring has properties that favor participating in a Cys-alkylating 1,4-addition reaction. Molecular modeling and docking analysis further revealed that EGCG bonds covalently with Cys-38 of NF-κB-p65, and thereby inhibits its DNA binding ability. We also generated a model pharmacophore based on the EGCG-NF-κB complex. We conclude that EGCG covalently binds to NF-κB-p65 and inhibits it by abolishing its DNA binding, by chemical mechanisms that may inform design of EGCG derivatives as novel anti-inflammatory agents.
Value of Interceptive Orthodontic Treatment for the Management of Sleep Disordered Breathing: A Prospective Longitudinal Study
Authors:   Department of Orthodontics and Dentofacial Malformations, Sant Joan de Déu Hospital, University of Barcelona, Spain, M Ordoñez , C De Pedro ,   Department of Orthodontics and Dentofacial Malformations, Sant Joan de Déu Hospital, University of Barcelona, Spain, M Monllau ,   Department of Orthodontics and Dentofacial Malformations, Sant Joan de Déu Hospital, University of Barcelona, Spain, I Vázquez ,   Department of Orthodontics and Dentofacial Malformations, Sant Joan de Déu Hospital, University of Barcelona, Spain, O Sans ,   Sant Joan de Déu Hospital, Institute of AdSalutem. Coordinator of the Sleep Disorder Unit, Spain, J Moncunill ,   Department of Orthodontics and Paediatric Dentistry, Sant Joan de Déu Hospital, Spain, A Rivera-Baró ,   Department of Orthodontics and Paediatric Dentistry, Sant Joan de Déu Hospital, Spain
Published: July 2021

Background: The paediatric population has a high incidence of sleepdisordered breathing (SDB). One notable risk factor for SDB is the presence of craniofacial abnormalities. The aim of this study was to evaluate the prevalence of SDB by means of questionnaires in patients who received interceptive treatment, to determine whether there is a relationship between the nature and duration of treatment and the prevalence of SDB, and to correlate cephalometric changes with the type of orthopaedic treatment received and questionnaire results. Materials and Methods: Prospective study of 203 patients who required interceptive treatment. Two sleep questionnaires (the Paediatric Sleep Questionnaire (PSQ) and the Sleep Disturbance Scale for Children (SDSC)) were used which were completed by the parents at baseline (T1) and after completion of interceptive treatment (T2). The results of the questionnaires were analysed, grouped according to the type of treatment received and related to 12 cephalometric variables on cephalometric radiography at T1 and T2. Results: The prevalence of SDB at T1 was 21.2% according to PSQ and 33% according to SDSC. The mean age at T1 was 8.5 years and the mean duration of treatment was 13.8 months. Between 10.8% (PSQ) and 17.2% (SDSC) of patients showed improvement in SDB after interceptive treatment (p<0.05). Treatment led to statistically significant cephalometric changes in the variables of mandibular length, maxillary length and overbite, with no significant differences between treatment groups or in relation to questionnaire results. Conclusion: Interceptive treatment achieves significant improvements in SDB. The type and duration of treatment do not affect the prevalence of SDB, although RPE is associated with a higher rate of improvement. The improvement in SDB is independent from the type of treatment and the cephalometric changes effected.
E-Learning versus Classroom Learning for Acquiring Knowledge about Precarity in Medicine
Authors:   Service des maladies infectieuses et tropicales, Centre Hospitalier Universitaire de Clermont-Ferrand, Centre de Référence des Infections Ostéo-articulaires, Centre de Référence Régional des Maladies Vectorielles liées aux Tiques, Laboratoire Microorganismes Génome et Environnement, Université Clermont Auvergne, Clermont-Ferrand, France, G Tanguy ,   Department of General Practice, Institut Pascal, CNRS, SIGMA Clermont, Clermont Auvergne University, Clermont-Ferrand, France, P Dessene ,   Médecins du Monde, délégation Auvergne Rhône-Alpes, Programme RESCORDA, Lyon, France, M Rude ,   Dispensaire émile Roux, Centre de lutte antituberculeuse (CLAT 63), Clermont-Ferrand, France, L Doly ,   Dispensaire émile Roux, Centre de lutte antituberculeuse (CLAT 63), Clermont-Ferrand, France, C Laurenson ,   Médecins du Monde, délégation Auvergne Rhône-Alpes, Programme RESCORDA, Lyon, France, M Gosgnach ,   Pôle (Ingénierie Pédagogique et Production Audiovisuelle (IPPA), Direction de la Formation, programme Learn'in Auvergne pour l'innovation pédagogique, Université Clermont Auvergne, site Carnot, 49 Boulevard François Mitterrand, Clermont-Ferrand Cedex 1, France, G Clement ,   Department of General Practice, Institut Pascal, CNRS, SIGMA Clermont, Clermont Auvergne University, Clermont-Ferrand, France, A Hersart De La Villemarque ,   Médecins du Monde, délégation Auvergne Rhône-Alpes, Programme RESCORDA, Lyon, France, L Ouchchane ,   Université Clermont Auvergne, CHU Clermont-Ferrand, CNRS, SIGMA Clermont, Institut Pascal, Clermont-Ferrand, France; Département de Santé Publique, Unité de Biostatistique et Informatique Médicale, CHU de Clermont-Ferrand, Clermont-Ferrand, France, O Lesens ,   Médecins du Monde, délégation Auvergne Rhône-Alpes, Programme RESCORDA, Lyon, France
Published: July 2021

The effect on knowledge levels immediately after a course on precarity in family medicine was assessed by comparing online learning against classroom learning, both followed by time for face-to-face discussion. Of 87 family medicine interns of the same class, 65 took part in the study and were evaluated, 34 being assigned to classroom learning and 31 to online learning. The increase in knowledge after the course was significantly higher in the online learning group (+27.8 points±11.2) than in the classroom group (+9.1 points±9.0) (p<0.0001).
COVID-19 patients’ interracial prevalence analysis: A statistically analysed distribution study
Authors: Mustapha Ibrahim Abdullahi  , Rakesh Das  , Mohd. Almas Khan  , Prabhjot Kaur Phull  , Mohd Wamiq Khan
Published: July 2021

The objective of this study is inspired from the immeasurable difference of COVID-19 incidence data between African & Indian population at peak prevalence month of its pandemic. Raw data analysis of Africa and India was schemed when COVID-19 situation as in peak on pandemic all over the world. The detected data distributions of inter-countries and other countries of Africa were comparatively studied on statistical basis of Correlation coefficient. The evaluation of p-values, ANOVA study with graphical representation on the comparative basis was carried out and interpreted. The screening of the large variation of data distribution has made uniform to get proper variation. The different mean± SD values are 67.142 ±69.91, 76.642± 66.747  & 77.21 ± 67.0215 and CV of these African countries shows 1.080, 0.90377 & 0.90076 respectively. Thus, ANOVA study showed no significance value, p < .05, where P-value is 0.913928 because of least variations. On the other hand, the % distribution of COVID-19 pandemic represents the wide difference of inter-continental difference of Africa from India, specifically of pie-chart. However, due to vast difference in COVID-19 intercontinental cases on restricted travellers interconnectivity tends to focus our attention to examine dietary roles in COVID-19.
The Academic Profession in Canada
Authors: Jefferson Alison
Published: July 2021

There is little research on the socialization of doctoral students in Canada. Using data collected as part of the Canadian sample of the Academic Professions in the Knowledge Society project, this paper explores the reported doctoral experience of full-time academic faculty in Canadian universities who were ‘successfully’ socialized to the role of scholar, to find potential factors affecting doctoral experience and career progression. This paper suggests that financial and faculty support are key to doctoral success. With disciplinary nuance alive and thriving, many contemporary doctoral students may be subject to unfair disadvantages, which may be of the underlying reasons for high attrition from doctoral programs. Results indicate teaching continues to be an overlooked aspect of doctoral training, in favor of research; the associated faculty support which often accompanies research, along with the potential for funding for the research-related activity, may be a significant factor in socialization.
BACTERIAS ENDOFÍTICAS DE ELODEA POTAMOGETON (“LLACHU”) DEL LAGO TITICACA
Authors:   Universidad Nacional del Altiplano, Puno - Perú, Coila Añasco Pedro Ubaldo , Bernabé Ortiz Julio César ,   Universidad Nacional de San Agustín, Arequipa – Perú, Ruelas Domingo Alberto ,   Universidad Nacional del Altiplano, Puno - Perú
Published: July 2021

ABTRACT: The “llachu” (Elodea potamogeton) is an aquatic plant from Lake Titicaca, food for the cattle of the circumlacustrine ring. Some areas of the lake have been eutrophied by pollution; even so, the plant grows. Being one of the survival mechanisms, the symbiotic interaction with microorganisms, the objective of the study was to isolate and molecularly characterize some endophytic bacteria of the plant. For isolation, the samples were washed and disinfected with 70% alcohol, 0.5% sodium hypochlorite and 80% Tween; then, it was homogenized and an aliquot seeded in Luria-Bertani (LB) medium, three strains were chosen to be reseeded on solid LB agar. From the pure strains, DNA was extracted with the phenol-chloroform-isoamyl alcohol mixture, quantifying by spectrophotometry. The 16S rDNA gene was amplified by PCR; amplicons were submitted to Functional Biosciences Inc. in the United States for sequencing. The sequences were edited with BioEdit 7.0.0 and similar sequences were chosen with BLASTn from GenBank, to perform multiple alignment of sequences with Clustal W. To determine evolutionary relationships, MEGA7 was used, constructing phylogenetic trees by the Neighbor-Joining method. Molecular analysis shows that the Sample10ped strain corresponds to Pantoea sp. with an identity greater than 76%; the Sample11pe strain to Pseudomonas sp. with 100% identity; and, to the strain Sample12ped to Raoultella terrígena sp. or Klebsiella sp. with an identity of 99%. The sequences of the last two were registered in GenBank, whose accessions are SUB4288247 and SUB4252655. Keywords: Endophytic bacteria, Elodea potamogeton, 16S rDNA gene, phylogeny
MODIFICACIÓN DE LA FORMA DEL EXTREMO DISTAL DEL PELO (PUNTA DEL CABELLO) DEBIDO AL DESGASTE NATURAL Y/O COTIDIANIDAD, HASTA CIEN DÍAS POSTERIORES AL CORTE
Authors:   Laboratorio de Biología Forense de la Oficina de Criminalística de la División de Investigación Criminal de Arequipa - Policía Nacional del Perú, Gutierrez Hancco Enrique , Santos Lovatón , Juan Edson ,   Laboratorio de Biología Forense de la Oficina de Criminalística de la División de Investigación Criminal de Arequipa - Policía Nacional del Perú
Published: July 2021

ABSTRACT: The tips of the hair were morphologically evaluated due to natural wear or daily activities (abrasion) from a young adult male (29 years old), mixed race (South American). Five hair samples were taken from the Frontal, Vertex, Occipital, Temporal (right and left) and Infratemporal (right and left) regions of the head. Daily activities generate wear to the cuticle by different mechanical processes and has greater incidence in the distal end of the hair (hair tip), to differentiate them based on time, and it was done by visual comparison with photography record day by day from the previous day until a rounded wear (blunt) was observed. The degree of wear of the hair tip in the comparative analysis of coeval samples of hairs with forensic interest can be a very relevant characteristic when trying to associate or exclude doubtful samples, with respect to a particular hair source. In this investigation, from the second week on, the narrowing and wear of the tips of the hairs became noticeable, reaching a completely rounded or blunt shape at maximum fourteen weeks. Key words: hair, tip, wear, head, temporal, infratemporal, forensic, rounded.
The Effect of ‘box-and-bead’ Analogy versus Retrieval-based Learning on Retention in Chemical Kinetics among First-Year Chemistry Students
Authors: Chinaka Taurayi Willard
Published: July 2021

The study examined the effects of the box-and-bead analogy versus retrieval-based learning on students’ retention and performance in chemical kinetics among first-year chemistry students. A purposive sampling technique was used to sample participants from the accessible population. The sample was made of two hundred and forty-five (n = 245) first-year chemistry students, at a public university, in South Africa. The study adopted a sequential explanatory research design. A chemical kinetics retention test (CKRT) was used for data collection as pre-, post-test and delayed post-test. A reliability coefficient of 0.73 was established using the Kuderson and Richardson correlation moment coefficient. Participants in the two groups were taught using an advanced retrieval instruction approach and the box-and-bead analogy. The results of the study showed no statistical difference in the retention of procedural knowledge and a statistical difference in conceptual knowledge. Overall, students taught using advanced retrieval performed better than the other group. The study underlines the fact that analogy-based instruction can be effective in improving conceptual knowledge using concrete analogues that aid in the retention of chemical kinetics. The findings of this study are diagnostic and they assist module designers in determining the procedural and conceptual knowledge in chemical kinetics retained by students, even after years have passed.
Dynamics of size classes of cities in Poland in 1950–2018
Authors: Runge Anna , Runge Jerzy
Published: July 2021

The study aims to present variability in the population of individual size classes of Polish cities in 1950-2018, its determinants and consequences for the formation of the settlement system. The application of quartiles as the basic statistical measure allowed identifying which parts of particular size classes of cities had the greatest impact (progressively or regressively) on changes in the settlement system. In this respect, strong dynamics of the upper quartile of Polish cities, lasting until the end of the 1970s, becomes apparent. In the 1980s, the dynamics of the upper quartile of large cities showed a shift during development waves in comparison to the culmination of these waves for medium-sized cities. However, since the end of the 1980s, there has been an increasing role of the lower quartile in determining the direction of changes in the size structure of cities, especially in medium and small cities.
Analysis of the key elements of the mechanism of formation of the system of intra-cluster interaction
Authors: Vasylchenko Anastasiia
Published: July 2021

The article considers the key elements that influence the mechanism of formation of the system of intra-cluster interaction. The article analyzes the competitiveness of the national economy as one of the system-forming factors, the mechanisms of self-organization of cluster formations, the properties of integration and cooperation of the participants of cluster formations, and it analyzes the structure of cluster system connections and develops the principles of state policy to promote the development of cluster formations.
The types of fertility patterns in Europe
Authors: Majdzińska Anna
Published: July 2021

The aim of this paper is to present the types of fertility patterns that characterise European countries and their NUTS-1 units in the early 21st c. and in the near future. The types of fertility patterns were defined by ordering six five-year age groups of women aged from 15 to 44 years, according to the groups’ fertility rates (from the highest to the lowest). The analysis resulted in the creation of 14 different types of fertility patterns. Countries located in the same European region tend to have the same or similar type of fertility pattern. In most European countries, the postponement transition can be observed, and it will probably continue in the future.

Differences between the fertility rates of the age groups were assessed within countries and between countries with the same type of fertility pattern by calculating the so-called fertility rate ratios. The paper also provides an overview of the main theories and concepts explaining the course of family formation processes in Europe and indicates factors that shape fertility patterns in European countries today.
Model Peningkatan Loyalitas Nasabah Internet Banking Berbasis Persepsi Resiko, Persepsi Privasi dimediasi Kepercayaan dan Kepuasan Nasabah
Authors: Muis Muhammad Ras , Fahmi Muhammad , Prayogi Muhammad Andi , Jufrizen Jufrizen
Published: July 2021

This study aims to examine the factors that influence internet banking customer loyalty in Medan City. The location of this research was carried out at several banks in the city of Medan. The population in this study were all bank customers who use internet banking and the total sample was 175 customers. Researchers used the Structural Equation Modeling assisted by the Lisrel 8.80 program in this research. The results showed that risk perceptions have a negatif and significant effect on customer satisfaction and customer trust. Perception of Privacy has a positive and significant effect on Customer Satisfaction and Customer Trust. Satisfaction has a positive and significant impact on Customer Trust. Perception of risk has a negatif and significant effect on customer loyalty. Perception of Privacy has a positive and insignificant effect on Customer Loyalty. Satisfaction has a positive and significant effect on Customer Loyalty and Trust Has a positive and significant effect on Customer Loyalty. Satisfaction and trust can negatifly mediate the effect of Risk Perception on Customer Loyalty. Satisfaction and trust can positively mediate the effect of Perceptions of Privacy on Customer Loyalty. Trust Satisfaction can positively mediate the effect of satisfaction on Customer Loyalty
Pentingnya Inovasi Produk dan Desain Produk Terhadap Keputusan Pembelian Berulang Pada Brand Iphone di Indonesia
Authors: Sari Sofi Kurnia , Isrofani Anggia Novanda , Pratiwi Citra , Batu Reminta Lumban
Published: July 2021

This research aims to explain the effect of the product innovation variables and product design partially on the repeated purchase decisions of an iPhone smartphone. This study uses 3 variables; namely product innovation (X1), product design (X2), and repeat purchase decisions (Y). Data collection was obtained by distributing questionnaires to the iPhone user community in Indonesia. The sample used in this study amounted to 100 respondents. Analysis of the data used is descriptive analysis, verification, normality test, and regression analysis. The sampling technique of this study was Stratified Random Sampling using the Slovin formula. The type of data used in this study is primary data and secondary data. The results of this study prove that Product Innovation and Product Design have a positive and significant effect on Repeated Purchasing Decisions.
Corporate Governance, Karakteristik Perusahaan dan Kinerja Perusahaan
Authors: Setiawan Rahmat , Nisa Ivone Dona Khoirun
Published: July 2021

The purpose of this research is to determine and explain the influence of corporate governance and firm characteristics on firm performance. This research uses manufacturing companies as samples and the number of observations is 228. Multiple linear regression testing is used as a method for research. The results show that corporate governance proxied by proportion of independent commissioners, company characteristics proxied by leverage and company size shows that both simultaneously and partially have an effect on company performance
Peran Komitmen Organisasional sebagai Variabel Mediasi pada Pengaruh Budaya Organisasi terhadap Organizational Citizenship Behavior
Authors: Serpian Serpian
Published: July 2021

This research aimed to examine the indirect effect of organizational culture on organizational citizenship behavior (OCB) through organizational commitment as the mediating variable. Formulation of the problem in this research attempted to know about what organizational commitment that can mediate the effect of organizational culture on OCB. The path analysis was used to examine 80 respondents. The sample collection was retrieved by asking employees from each main branch banks to spread out the questionnaires. Researcher deployed 103 questionnaires yet only 86 questionnaires was returned and 80 questionnaires could be examined. These variables had been previously verified in BNI life Regional Makassar. This research concerns on the problems of the high rate of employee turnover in BNI life regional Makassar. Every year, many employees decide to resign from the bank. Besides, this research was based on the research gap, the different results of research by Giri, Nimran, Hamid, Musadieq (2016), and Meijen (2007). A study by Giri, Nimran, Hamid, Musadieq (2016) showed that there are the significant impacts of organizational culture on organizational commitment. In contrast, the result of research by Meijen (2007) revealed that there was no impact on the variables. The result of this research found that there is an indirect impact between organizational cultures on organizational citizenship behavior (OCB) through organizational commitment as the mediating variable. The conclusion is the strategic decision making related to human resource development must consider organizational culture.
On real algebraic numbers in which the derivative of their minimal polynomial is small
Authors: Koleda D. V.
Published: July 2021

Algebraic numbers are the roots of integer polynomials. Each algebraic number α is characterized by its minimal polynomial Pα that is a polynomial of minimal positive degree with integer coprime coefficients, α being its root. The degree of α is the degree of this polynomial, and the height of α is the maximum of the absolute values of the coefficients of this polynomial. In this paper we consider the distribution of algebraic numbers α whose degree is fixed and height bounded by a growing parameter Q, and the minimal polynomial Pα is such that the absolute value of its derivative P'α (α) is bounded by a given parameter X. We show that if this bounding parameter X is from a certain range, then as Q → +∞ these algebraic numbers are distributed uniformly in the segment [-1+√2/3.1-√2/3]
On some properties of p-holomorphic and p-analytic function
Authors: Vassilyev I. L. , Dovgodilin V. V.
Published: July 2021

In this article the relationship between the conditions of p-differentiability, p-holomorphycity, and the existence of the derivative of a function of a p-complex variable is considered. The general form of a p-holomorphic function is found. The sufficient conditions for p-analyticity and local invertibility are obtained. The open mapping theorem and the principle of maximum of the norm for a p-holomorphic function and the uniqueness theorem are proved.
n-Homogeneous C*-algebras
Authors: Shchukin M. V.
Published: July 2021

The classical results by J. Fell, J. Tomiyama, M. Takesaki describe n-homogeneous С*-algebras as algebras of all continuous sections for an appropriate algebraic bundle. By using this realization, several authors described the set of n-homogeneous С*-algebras with different spaces of primitive ideals. In 1974 F. Krauss and T. Lawson described the set of all n-homogeneous С*-algebras whose space Prim of primitive ideals is homeomorphic to the sphere S2. Suppose the space PrimA of primitive ideals is homeomorphic to the sphere S3 for some n-homogeneous С*-algebra A. In this case, these authors showed that the algebra A is isomorphic to the algebra C(S3,Cn×n). If n ≥ 2 then there are countably many pairwise non-isomorphic n-homogeneous С*-algebras A such that PrimA ≅ S 4. Further, let n ≥ 3. There is only one n-homogeneous С*-algebra A such that PrimA ≅ S 5. There are two non-isomorphic 2-homogeneous С*-algebras A and B with space PrimA ≅ S 5. On the other hand, algebraic bundles over the torus T 2 are described by a residue class [p] in Z/nZ = π1(PUn). Two such bundles with classes [pi] produce isomorphic С*-algebras if and only if [p1] = ±[p2]. An algebraic bundle over the torus T 3 is determined by three residue classes in Z/nZ. Anatolii Antonevich and Nahum Krupnik introduced some structures on the set of algebraic bundles over the sphere S2. Algebraic bundles over the compact connected two-dimensional oriented manifolds were considered by the author. In this case, the set of non-equivalent algebraic bundles over such space is like the set of algebraic bundles over the torus T2. Further advances could be in describing the set of algebraic bundles over the 3-dimensional manifolds.
Transient absorption spectral dynamics of hybrid associates of CdS quantum dots and methylene blue dye
Authors: Tikhomirov S. A.
Published: July 2021

The transient absorption spectra dynamics for hybrid associates of colloidal CdS quantum dots, passivated by thioglycolic acid (CdS/TGA QDs), and methylene blue cationic dye molecules (MB+) were studied by femtosecond spectroscopy. It was established that one of the main channels of relaxation of the CdS/TGA QDs excitation energy in hybrid associates based on CdS/TGA QDs and MB+ is a fast energy transfer to the reduced forms of MB+ (MBOH•, MB•) that are formed still at the synthesis stage of samples. This channel strongly competes with the resonant energy transfer from the centers of radiative recombination in quantum dots to MB+. Therefore, for hybrid associates based on QDs/TGA and methylene blue, there is no any noticeable signal of the transient absorption corresponding to the triplet state of MB+ dye, which is then known to be actively involved in charge transfer.
New immunoassay systems based on recombinant human lactoferrin
Authors: Semenov D. A. , Vashkevich I. I. , Sviridov O. V.
Published: July 2021

In this work, soluble and solid phase immunoreagents, including recombinant human lactoferrin (rhLF), a complex of rhLF with europium ions, rabbit antiserum to rhLF, anti-rhLF immunoglobulin purified by antigen-affinity chromatography and the conjugates of this immunoglobulin with an Eu3+ chelate or horseradish peroxidase have been obtained by a combination of biochemical and synthetic methods using rhLF as an initial compound. Biospecific interactions of the reagents in four immunochemical systems were assessed by measuring the enzyme activity or time-resolved fluorescence. The study resulted in the development of fast and precise immunoassays for biologically active rhLF in transgenic goat milk and in protein fractions obtained in the course of pure rhLF manufacture, as well as in pharmaceutical preparations and food additives.
Estimation of the selectivity of sorbents for IgG binding based on tripeptide ligands
Authors: Pustsyulga Y. S. , Gribovskaya O. V. , Ermola E. M. , Golubovich V. P. , Moiseenok A. G.
Published: July 2021

Biospecific sorbents for the removal of IgG and subclasses from biological fluids based on oligopeptides, containing aromatic amino acid residues, were created. The selectivity properties of specific sorbents for IgM, IgE, and plasma proteins were evaluated. It was found that the created sorbents exhibit the low activity to the total plasma protein, albumin, IgM, IgE and are highly specific for IgG.
Transport of organic anions in root cells and its role in cell signaling in higher plants
Authors: Demidchik V. V. , Hryvusevich P. V. , Vaitsiakhovich M. A. , Talkachova J. V. , Kulinkovich A. V. , Sokolik A. I.
Published: July 2021

The organic anion balance is critical for metabolic, bioenergetic, and electrochemical processes in plant cells, controlling the quality and quantity of yield and plant stress resistance. Nevertheless, the redistribution and membrane transport of these substances in plant tissues have not been investigated in detail. The mechanism of passive anion efflux from a plant cell through the ion channels has not been established so far. Here, using the patch-clamp technique, we have characterized the ion channel-mediated conductances of ascorbate, malate, gluconate, citrate, fumarate, and pronionate in the root cells of Arabidopsis thaliana, Triticum aestivum, and Helianthus annuus. These conductances showed high permeability to ascorbate, malate, and citrate, as well as low permeability to fumarate, propionate, and gluconate. Anion channel conductances of root cells showed rapid activation kinetics and low potential dependence. They were also inhibited by 9-anthracenecarboxylic acid, suggesting that they belong to the ALMT family of anion channels found only in higher plants. Aequorin chemilu minometry was used to test the effect of organic anions on the Ca2+ signaling in root cells. Among four organic anions tested, only ascorbate induced a significant increase in the cytosolic Ca2+ activity at physiological levels (1 and 10 mM). This effect may underlie the previously unknown functions of exogenous ascorbate related to short- and long-distance signaling in higher plants.
Assessment of the differential gene expression in anthracnose treated seedlings of yellow lupin
Authors: Sysoliatin E. N. , Anokhina V. S. , Anisimova N. V. , Babak O. G. , Kilchevsky A. V.
Published: July 2021

Seedlings of yellow lupine treated with Colletotrichum lupini isolate were studied by the method of SRAP-analysis with the purpose to assess the differential expression of genes. As a result, the PCR fragment corresponding to tolerant seedlings was found. The genetic determinants found are likely involved in the control of the resistance (tolerance) of lupine plants to anthracnose.
Lumican expression in chronic degenerative cornea diseases
Authors: Semak G. R. , Zakharava V. A. , Zherka I. Yu. , Yudin P. Yu.
Published: July 2021

The pattern of lumican expression in corneal explants of patients with chronic dystrophic cornea diseases and the changes in its expression after 1 % sodium hyaluronate expression are established. The prospective study included 37 patients with chronic dystrophic diseases of the cornea: keratopathies in the outcome of keratitis (20 cases) and endothelial-epithelial dystrophy (17 cases). The patients were divided into 2 groups. The first group in the preoperative period received the injections of 1 % low molecular weight sodium hyaluronate, the second group did not receive additional treatment. All patients included in the study underwent penetrating keratoplasty. The immunohistochemical study of corneal explants was performed using primary monoclonal antibodies to lumican with subsequent morphometric evaluation of the preparations. The proportion of pixels with high and moderate intensity and the index of expression intensity in immunopositive regions were calculated. In the group of patients with aggressive keratitis, the intensity of lumican expression both in the epithelium and in the corneal stroma was statistically significantly higher than in the control group and decreased with the use of 1 % low molecular weight sodium hyaluronate. After the leukoma formation, the expression of lumican both in the epithelium and in the corneal stroma was comparable to that in the control group with higher parameters of epithelial expression after sodium hyaluronate administration. In the groups of endothelial-epithelial dystrophy, an increase in the intensity of expression was noted after sodium hyaluronate injections. The noted increase in the epithelial expression of lumican against the background of pronounced alteration is accompanied by its gradual decrease as the regeneration is completed. An important factor is its normal content in the corneal stroma, since both a sharp increase and low expression parameters are accompanied by a decrease in corneal transparency.
Optimization of the taper angle of the jetter confuser used for reversible blast cleaning of propellers from corrosion
Authors: Kovalevich V. S. , Kachanov I. V. , Shatalov I. M. , Veremenyuk V. V. , Filipchik A. V.
Published: July 2021

It is shown that it is very effective to remove corrosion products from various surfaces, including the metal surface of the propeller, using the new technology of reverse-jet cleaning (RJC) developed by the authors. The RJS technology is based on the physical principle that the jet of the working fluid (pulp based on river sand or bentonite clay), upon impact with the surface to be cleaned, turns 180°, which leads to an increase in the jet effect on the surface to be cleaned by 1.5–2 times due to the occurrence of the reactive component. To ensure the marked turn of the jet, an original design of the body was developed, which is distinguished by a patent novelty. One of the main elements in this design is a jet-forming device in the form of a confuser. The presented theoretical studies of the pressure loss of the working fluid in the confuser channel, based on the study of the pressure loss function to the extremum, which made it possible to obtain a dependence for calculating the optimal taper angle in a wide range of Reynolds numbers characterizing the turbulent mode of motion taking into account the influence of the working fluid density and its dynamic viscosity, the average speed of movement of the working fluid, the radius of the confuser, as well as the coefficient of equivalent roughness, i.e. from gradual wear of the confuser channel. The resulting dependence can be recommended for calculation in the design of jet cleaning devices and other installations of jet technology.
Steam and plasma bubble evolution on laser treating of a sample being in liquid
Authors: Vasiliev S. V. , Ivanov A. Yu. , Kopytskiy A. V. , Sitkevich A. L.
Published: July 2021

An object of investigation is pointed - the metal articles being in water and exposed to pulse laser treating. The purpose of research was the investigation of the processes occurring near the metal target treated by pulse laser radiation with flux density ∼106 W/cm–2. The results of the experimental investigation of the pulse laser treating of a led target being in water are described. The process of steam and gas plume generation on the surface of the irradiated metal was investigated experimentally. The features of steam and gas plume form and dimensions evolution on different stages of the process (even after completion of laser treating of the material) were investigated. It is shown that when using GOR-100M operating in free oscillating regime (pulse duration 1.2 ms, laser radiation flux density ∼106 W/cm–2), the form of a crater developed on the irradiated target surface being in water essentially differs from the topography of the crater developed on the analogical target surrounded by air at normal pressure (105 Pa). It is pointed in the conclusions that the substantial difference of the forms of crater surfaces developed as a result of processing of the identical targets being in water or air by laser pulses with the identical parameters , determines by principally different character of plasma and steam and gas mixture flow in the mentioned cases.
QURAQLIQ - MƏHSULDARLIQ ƏLAQƏLƏRİNİN TƏDQİQİ
Authors: Məmmədov Ə.S, , Мамедова V.Р.
Published: July 2021

Abstract: The increase in temperature is accompanied by a decrease in precipitation in some regions of the globe, an increase in the frequency of droughts. In this
case, of course, the threat of a decline in agricultural productivity is inevitable. Of
course, in some regions, the opposite process can occur, ie it can lead to an increase
in temperature, increased precipitation and a decrease in the tendency of droughts.
In this case, productivity increases. The article clarifies the factors that affect the increase and decrease of productivity.
Keywords: trend, angle coefficient, drought, productivity
ИЗМЕНЧИВОСТЬ ГОДОВОГО СТОКА РЕКИ АЛАЗАНИ (ГАНЫХ)
Authors: Иманов Ф.А , Кордзахия Г.И. , Алиева И.С
Published: July 2021

Abstract. The analysis of spatial and temporal regularities of the annual runoff
of the transboundary river Alazani (Ganikh), which flows through the territory of
Georgia and Azerbaijan, has been carried out. The series on the average annual water
discharge of 6 hydrological gauges for the period from 1925 to 2017/2019 was used.
It was found that for the researched rivers, the fluctuations of the average annual
water discharges are in phase, however, the absence of strict synchronicity in the
fluctuations of the annual runoff leads to a decrease in the spatial correlation coefficients. In the studied series of river Alazani (Ganikh) both on the territory of Georgia and Azerbaijan, there is no trend; however, for a number of annual runoff of the
Ayrichai River, the main tributary of the r. Alazani (Ganikh), a significant positive
trend was revealed. It should be noted that the reason for the nonstationarity is the
climate change, the impact of which on runoff has become noticeable in recent
decades. It was found that the variance of the second half of the analyzed series increased. The annual runoff of the Alazani (Ganikh) River has changed very little
over 1991-2017 / 2019 compared with the period 1961-1990. For the Ayrichai River,
the second period is characterized by increased water content.
Keywords: River Alazani (Ganikh), Annual runoff, Water discharge, Transboundary river, Runoff change.
HUBUNGAN KADAR KOLESTEROL DENGAN KEJADIAN KLAUDIKASIO KEHAMILAN DI WILAYAH KERJA PUSKESMAS LINTAU BUO UTARA
Authors: Jesica Fanny
Published: July 2021

Pada dasarnya kolesterol menyerang semua bagian tubuh yang memiliki pembuluh darah. Kolesterol bisa menyumbat pembuluh darah jantung, tapi bisa juga mempengaruhi kaki.2,3 Menurut Direktur Terapi di Montefiore Medical Centre, sebanyak 12 juta orang di Amerika memiliki kolesterol yang menyerang bagian kaki. Berita baiknya, penyakit ini bisa diobati.1,4Ditenggarai salah satu penyebab klaudikasio pada ibu hamil adalah penyumbatan aliran darah oleh kolesterol.5 Tujuan penelitian ini adalah untuk mengetahui hubungan kadar kolesterol dengan kejadian klaudikasio selama kehamilan. Penelitian ini merupakan penelitian observasional dengan desain penelitian cross-sectional. Jumlah sampel sebanyak 30 responden yang dipilih secara consecutive sampling. Kemudian hasil pemeriksaan akan dilakukan analisis bivariat dengan uji chi-square. Adapun hasil penelitian menyatakan bahwa terdapat hubungan bermakna antara kadar kolesterol dengan kejadian klaudikasio selama kehamilan dengan nilai p 0,001 dan dapat ditarik kesimpulan semakin tinggi kolesterol selama kehamilan maka semakin tinggi risiko mengalami klaudikasio selama kehamilan.
HUBUNGAN KADAR TEMBAGA DALAM ASI DENGAN BERAT BADAN BAYI 0-6 BULAN DI WILAYAH KERJA PUSKESMAS LUBUK BUAYA
Authors: Amir Aprima Yona
Published: July 2021

Kemampuan ASI untuk membantu pertumbuhan sangat ditentukan oleh kandungan nutrisi yang terdapat dalam ASI, ASI terdiri sari vitamin dan mineral, salah satunya kandungan mineral dalam ASI adalah Tembaga. 1,4 Tembaga merupakan salah satu elemen yang penting pada manusia, baik kekurangan maupun kelebihan tembaga dapat menyebabkan gangguan pada kesehatan tubuh. 2,3Tujuan penelitian ini untuk melihat hubungan kadar tembaga dalam ASI dengan berat badan bayi usia 0-6 bulan. Metode penelitian ini adalah cross sectional study. Responden penelitian adalah 40 orang ibu yang mempunyai bayi usia 0-6 bulan yang menyusui secara ekslusif di Puskesmas Lubuk Buaya Padang yang masuk kriteria inklusi dan ekslusi. Kadar magnesium dalam ASI diperiksa di Balai Laboratorium Kesehatan (BLK) Kota Padang. Data dianalisis dengan menggunakan uji korelasi pearson. Hasil penelitian didapatkan rata-rata kadar tembaga dalam ASI adalah 0,21 mg/dl ± SD. Terdapat hubungan yang signifikan kadar tembaga dalam ASI dengan penambahan berat badan bayi (p=0,07). Pada penelitian ini dapat disimpulkan terdapat hubungan yang signifikan kadar tembaga dalam ASI dengan berat badan bayi usia 0-6 bulan.
Fuel consumption efficiency regarding the road quality in the coal mine: a case study
Authors: Laura Puspita Sari
Published: July 2021

Fuel requirements have a direct impact on mining activities. The operator's habits influence the amount of fuel used in operating the equipment, the mine road's slope, and the distance predetermined in the mine design planning. Adjustment Fuel Consumption Actual (AFCA) is the fuel cost, which is influenced by the fuel price, distance, and condition of the mining road billed for overburden and coal mining activities carried out by the contractor. The research methodology uses off-site and on-site analysis. Off-site analysis can be carried out the highest 'Fuel Ratio' owned by the machine based on its specifications and operational activities to find out how much fuel consumption is needed to produce the amount of production per hour (liters/bcm). Meanwhile, it needs to be correlated with the mine road's condition, including the slope of the mine road (grade). This study aims to determine the relationship between road grade and fuel consumption by comparing road grade improvement efforts with cost-benefit analysis.
THE EFFICACY OF LASER THERAPY AND IBUPROFEN ON PAIN AFTER ELASTOMERIC SEPARATOR PLACEMENT: RAPID REVIEW
Authors: Simarmata Regina Yosephine , Evangelina Ida Ayu , Laviana Avi , Mardiati Endah
Published: July 2021

Background: Separator placement is the first step in orthodontic treatment, which aims to create space between teeth before molar band placement. This procedure can cause pain for the patient. Pain management after separator placement can be done through pharmacological and non-pharmacological approaches.Method: The aim of this rapid review was to determine the efficacy of laser therapy and ibuprofen for pain management after elastomeric separator placement in orthodontic treatment.Result: Ten articles were included in this review, four articles gave laser therapy interventions and six articles gave ibuprofen therapy interventions. The result of the quality assessment using Strength of Recommendation Taxonomy (SORT) was laser therapy intervention has one good quality articles and three limited-quality articles, while ibuprofen therapy has two good quality articles and four limited-quality articles.Conclusion: The efficacy of laser therapy and the efficacy of ibuprofen on pain after separator placement is good, with the strength of the clinical recommendation of ibuprofen is better than laser therapy.
Weed Dynamics of Hybrid Rice under the Influence of Fertilizer Levels and Weed Management Practices
Authors: Nagarjuna Polagani
Published: July 2021

A field experiment entitled “Weed Dynamics of Hybrid Rice under the Influence of fertilizer Levels and Weed Management Practices” was conducted during the Kharif season of 2017 at the Research Farm, TCA, Dholi, Dr. Rajendra Prasad Central Agricultural University, Pusa, Samastipur (BIHAR). The experiment was laid out in a split-plot design with twelve treatments. Among different levels of fertilizer, application of 100 % RDF recorded a minimum number of weeds/m2 (58.36/m2), weed dry weight production (73.12 g/m2), and weed growth rate (0.024 g/m2/day). In the case of weed management practices, Hand weeding (twice) was found to be the most efficient weed control (71.32%), a minimum number of weeds/m2 (25.11/m2), weed dry weight production (21.12 g/m2) and weed growth rate (0.011 g/m2/day) but the minimum weed index (45.87%) was observed in weedy check.
AVALIAÇÃO DA QUALIDADE DE VIDA E A FREQUENCIA DOS SINTOMAS DE DEPRESSÃO, DOR E FADIGA EM MULHERES MASTECTOMIZADAS QUE REALIZARAM FISIOTERAPIA COM EXERCÍCIOS DE MEMBROS SUPERIORES EM SERVIÇO DE REABILITAÇÃO DO HOSPITAL DE CÂNCER DE PERNAMBUCO-PE
Authors: MERGULHÃO COELHO LUCIANA MARIA
Published: July 2021

O Câncer de mama é um grave problema de saúde publica por ser o tipo de neoplasia maligna mais frequente na população feminina. Para o Brasil são estimados 66.280 novos casos de CA de mama. Para os anos de 2020- 2022. O objetivo do estudo foi avaliar a qualidade de vida e a frequência de sintomas de depressão dor e fadiga das pacientes mastectomizadas que realizam fisioterapia com exercícios no serviço de reabilitação do hospital de câncer de Recife PE. Estudo descritivo e quantitativo utilizando a aplicação de um questionário de qualidade de vida SF-36 e no final feitas analises estatísticas com o programa Microsoft Excel. Responderam o questionário 60 pacientes mastectomizadas unilateral por CA de mama, com ou sem esvaziamento axilar com idade de 30 a 80 anos que realizam fisioterapia com exercícios nos membros superiores no Hospital do Câncer de PE. Constatou-se que a depressão, a dor e a fadiga, e a dificuldade na mobilidade apresentaram um resultado significativo entre as pacientes em estudo, influenciando na qualidade de vida. Os resultados observados sugerem que a qualidade de vida das mulheres mastectomizadas está associada a fatores físicos e emocionais e que frequentar um serviço de reabilitação tem relevância para vislumbrar, melhora na qualidade de vida.
Profil “Kontemporer” Musik Kelahiran Minang
Authors: Mahdi Bahar
Published: July 2021

one of musical entities in West Sumatera is the Minangkabau cultural music. The existence of the music has changed significantly since the second half of twentieth century, as an intergral change of Indonesian music in general. Following the situation I see the emergence of academic discussions on the music in a member of forums in this republic. In the discussion, many terms are adopted from foreign languages, especially English, such as “contemporary”. Various meanings given to “contemporary” are used to define the phenomena of changes in music in the countri. One of a newly-created music as a phenomenon of change in the Minangkabau cultural context is “Kawin Silang” composition. The composition in this article is discussed in the contemporary perspective.