bluuebunny/crossref_metadata_2025 huggingface dataset:
ORTODOKSI DAN HETERODOKSI NILAI-NILAI DI PESANTREN: STUDI KASUS PADA PERUBAHAN PERILAKU SANTRI DI ERA TEKNOLOGI DIGITAL
Authors: Mundiri Akmal , Nawiro Ira
Published: July 2019

Abstak
Perkembangan teknologi mempengaruhi hampir setiap lini kehidupan, termasuk kehidupan santri di pesantren. Penelitian ini bertujuan untuk mengungkap transformasi perilaku santri, ortodoksi dan heterodoksi, akibat dari perkembangan teknologi di dunia pesantren. Penelitian ini menggunakan pendekatan kualitatif dengan jenis studi kasus. Hasil penelitian menunjukkan beberapa perilaku ortodoksi yang sudah ada sejak dahulu masih terjaga di pesantren, seperti berpakaian sopan, mahir membaca kitab kuning bahkan memahami isinya, selalu mematuhi peraturan pesantren, menghormati yang lebih tua dan menyayangi yang lebih muda. Akan tetapi, terdapat pula perilaku yang menyimpang (heterodoksi) yang muncul akibat perkembangan zaman seperti imitasi budaya k-pop, minimnya kemampuan membaca kitab, melanggar tata tertib pesantren, bullying, transformasi otoritas keagamaan santri dan berubahnya sumber primer pembelajaran santri. Namun, terdapat beberapa perilaku yang tetap menjadi ciri khas pesantren seperti solidaritas, mandiri, ta'dzim terhadap kiai, juga mengelola pembelajaran sendiri.  
Abstract
Technological developments affect almost every line of life, including the lives of santri in pesantren. This study aims to uncover the transformation of santri behavior, orthodoxy and heterodoxy, a result of technological developments in the pesantren world. This study uses a qualitative approach with a type of case study. The results showed that some of the orthodoxy behavior that had existed since long ago was still awake in Islamic boarding schools, such as dressing modestly, proficient at reading yellow books and even understanding its contents, always obeying the pesantren's rules, respecting the older and loving younger ones. However, there are also deviant behaviors (heterodoxy) that arise due to the current development, such as imitation of k-pop culture, lack of ability to read books, violating pesantren rules, bullying, transformation of santri religious authority and the change in primary learning sources of santri. However, there are several behaviors that remain the characteristics of pesantren such as solidarity, independence, ta'dzim towards kiai, and managing their own learning.
OS LIMITES DA DEMOCRACIA: A TOLERÂNCIA RESTRITA E A CRIMINALIZAÇÃO DO TERRORISMO
Authors: Dissenha Rui Carlo , Vidal Guaragni Giovanni
Published: July 2019

O intuito do presente artigo é, a partir de uma abordagem teórica, com documentação indireta de fontes secundárias, e uma metodologia hipotético-dedutiva, apontar limites inerentes ao projeto político democrático ocidental e averiguar as consequências às searas política e jurídico-penal. A democracia busca sustentação em quatro principais pilares: pluralidade, tolerância, liberdade e igualdade. Tais valores fundamentais costumam conflitar, restando à política democrática a harmonização entre liberdade e igualdade e a manutenção de relações conflitivas, o que garante a pluralidade e tolerância e, com isso, a própria democracia.  As democracias ocidentais contemporâneas, entretanto, buscando proteção contra modelos de pensamento intolerantes, adotam o chamado “princípio da tolerância restrita”, que legitima a intolerância contra os intolerantes, transformando-se em modelos paradoxais, tendentes à autofagia em razão da formação de consensos e da eliminação da pluralidade. O combate democrático à intolerância se manifesta de maneira sintomática na aplicação do poder punitivo e na criminalização do terrorismo, em um Direito Penal menos garantidor do que o destinado aos cidadãos comuns. Sociedades que se pretendam democráticas devem se afastar do duplo gume da tolerância restrita, adotando os eixos da liberdade democrática, da educação democrática e do controle democrático, erigindo um sistema punitivo mínimo, dedicado à criminalização de condutas lesivas a bens jurídicos e não a valores democráticos.
Reduced Expression of Sprouty1 Contributes to the Aberrant Proliferation and Impaired Apoptosis of Acute Myeloid Leukemia Cells
Authors: Rosso Valentina , Panuzzo Crisitina , Petiti Jessica , Carturan Sonia , Dragani Matteo , Andreani Giacomo , Fava Carmen , Saglio Giuseppe , Bracco Enrico , Cilloni Daniela
Published: July 2019

In most of acute myeloid leukemia patients there is an aberrant tyrosine kinases activity. The Sprouty family proteins were originally identified in Drosophila melanogaster as antagonists of Breathless, the mammalian ortholog of fibroblast growth factor receptor. This family proteins are inhibitors of RAS signaling induced by tyrosine kinases receptors and they are implicated in negative feedback processes regulating several intracellular pathways. The present study aims to investigate the role of a member of the Sprouty family, Sprouty1, as regulator of cell proliferation and growth in patients affected by acute myeloid leukemia. Sprouty1 mRNA and protein were both significantly down-regulated in acute myeloid leukemia cells compared to the normal counterpart, but they were restored when remission is achieved after chemotherapy. Ectopic expression of Sprouty1 revealed that it plays a key role in the proliferation and apoptotic defect that represent a landmark of the leukemic cells. Our study identified Sprouty1 as negative regulator involved in the aberrant signals of acute myeloid leukemia. Furthermore, we found a correlation between Sprouty1 and FoxO3a delocalization in AML at diagnosis, suggesting a multistep regulation of RAF–MEK–ERK signaling in human cancers. 
CO2 Concentration and Occupancy Detection of Educational Buildings for Energy Efficiency Purposes: An Experimental Analysis
Authors: Franco Alessandro , Leccese Francesco
Published: July 2019

The problem of real-time estimation of occupancy of buildings (number of people in various zones at every time instant) is relevant to a number of emerging applications that achieve high energy efficiency through feedback control. The measurement of CO2 concentration can be considered an important indicator that allows to define the occupation of closed and crowded spaces. Interesting cases can be school buildings and other buildings used in civil and residential (shopping centres, hospitals, etc.). This paper, starting from an experimental analysis in different classrooms of a University campus in real operating conditions, in different period of the year, proposes a possible correlation between CO2 concentration and the occupancy profile of the spaces. The acquired data are used to present some graphical correlations and to understand the most important variables or combination of them. Starting from an accurate analysis of the data, attempts are made to define a preliminary estimation method through the development of a mathematical models of occupancy dynamics in a building, which show interesting results.
PEMODELAN PEMROGRAMAN LINIER DENGAN KOEFISIEN FUNGSI OBJEKTIF, FUNGSI KENDALA DAN VARIABEL KEPUTUSAN BERBENTUK BILANGAN KABUR BESERTA APLIKASINYA
Authors: Amrullah Muhammad
Published: July 2019

Abstrak Dalam penelitian ini penulis akan mengusulkan algoritma untuk memodelkan masalah pemrograman linear kabur dengan bilangan kabur trapesium menggunakan metode simpleks. Secara khusus dalam aplikasi teori ini adalah masalah pengambilan keputusan pemrograman linear kabur dengan menyajikan metode baru untuk menyelesaikan masalah pemrograman linier kabur dengan menggunakan fungsi ranking. Pada dasarnya, langkah-langkah dalam metode penelitian ini sama dengan dengan metode simpleks yang digunakan untuk memecahkan masalah pemrograman linier tegas.Kata kunci: Fuzzy linear programming, fungsi ranking, metode simpleks. AbstractIn this paper author shall propose an algorithm for solving fuzzy linear programming problems with trapezoidal numbers using a simplex method. In particular, an application of  this theory in decision making problems is fuzzy linear programming with a new method for solving fuzzy linear programming problems, by use of rank function. Basically, our method is similar to simplex method that was used for solving linear programming problems in crisp environment before.Keywords: Fuzzy linier programming, rank function, simplex method.
NILAI EIGEN MATRIKS QUATERNION
Authors: Ekawati Susi
Published: July 2019

AbstrakMenurut Zhang (2007), jika  adalah matriks quaternion dengan  dan  adalah nilai eigen kiri dari , maka . Dalam penelitian ini akan ditunjukkan tiga hal. Pertama, jika  adalah matriks quaternion dengan  dan  adalah nilai eigen kiri dari  maka .Kata Kunci : Quaternion, Determinan Cayley, Nilai Eigen Kiri AbstractAccording to Zhang (2007), if  is a quaternion matrix with  and  is the left eigenvalue of , then . In this paper will be shown, if  is a quaternion matrix with  and  is the left eigenvalue of , then .Keywords : Quaternion, Cayley Determinant, Left Eigenvalue
Analisis Risiko Pada Return Saham Perusahaan Asuransi Menggunakan Metode VaR dengan Pendekatan ARMA-GARCH
Authors: Kuswanto Heri , Damayanti Endy Norma Chyntia
Published: July 2019

Pasar modal Indonesia merupakan salah satu negara tujuan investasi bagi investor di negara-negara maju (developed markets) yang dikenal sebagai emerging market. Perkembangan kondisi perekonomian di Indonesia sendiri dianggap baik bagi para investor untuk menanamkan dana. Saham sektor keuangan menjadi salah satu sektor yang ikut berkembang di sepanjang tahun ini. Tiga dari tujuh saham yang menunjukkan bertumbuh dengan baik adalah PT Asuransi Multi Artha Guna Tbk (AMAG), PT Paninvest Tbk (PNIN), dan PT Lippo General Insurance Tbk (LPGI). Terdapat dua hal penting yaitu tingkat pengembalian atau imbal hasil (return) dan risiko. Komponen lain yang tidak kalah penting adalah volatilitas return saham. Berdasarkan penjelasan diatas, maka dilakukan penelitian untuk menganalisis return saham dan volatilitas ketiga saham. Salah satu metode yang digunakan dalam mengestimasi risiko saham adalah metode VaR (Value at Risk). Untuk mengatasi volatilitas dapat menggunakan ARMA dan GARCH. Dihasilkan bahwa tiga saham perusahaan memberikan nilai rata-rata return yang positif sehingga memberikan keuntungan bagi investor. Saham perusahaan LPGI memiliki potensi risiko yang paling tinggi karena nilai standar deviasi yang tinggi. Model terbaik untuk return saham AMAG adalah ARMA ([7],[7]) dan model GARCH (1,2). Pada return saham LPGI model terbaik adalah ARMA ([2],[2]) dan GARCH (1,1). Return saham PNIN diperoleh model terbaik ARMA (0,[3]) dan GARCH (1,2). Pada pemodelan Parsimony didapatkan model ARMA (1,0) GARCH (1,1) untuk return saham perusahaan AMAG, ARMA (0,1) GARCH (1,1) untuk return saham perusahaan LPGI dan ARMA (1,1) GARCH (1,1) untuk return saham perusahaan PNIN. Pada perhitungan VaR didapatkan investor akan mengalami kerugian maksimum sebesar Rp 47.089.529,- bila menanamkan modal sebesar Rp 1.000.000.000,- di perusahaan AMAG, berlaku pula pada perusahaan LPGI, investor akan mengalami kerugian sebesar Rp 60.018.734,- dan Rp 39.196.540,- di perusahaan PNIN dengan tingkat keyakinan 95%.
Analisis Komponen Utama Pada Data Potensi Kecamatan di Kota Palu Sebelum Bencana Gempa Bumi dan Tsunami 28 September 2018
Authors: Purnama Drajat Indra
Published: July 2019

Pada tanggal 28 September 2018 peristiwa gempa bumi berkekuatan 7,4 SR diikuti dengan tsunami melanda Kota Palu. Gempa bumi dan tsunami memakan ribuan korban jiwa, ribuan orang mengungsi, ribuan bangunan hancur dan kerusakan infrastruktur di Kota Palu. Selain itu, dampak bencana gempa bumi dan tsunami ini berpengaruh terhadap pembangunan Kota Palu. Pembangunan yang susah payah dibangun dan memerlukan waktu lama, tiba-tiba hancur seketika karena gempa bumi dan tsunami. Penelitian ini difokuskan pada potensi kecamatan di Kota Palu sebelum terjadi bencana gempa bumi dan tsunami. Adapun data yang digunakan berasal dari publikasi Kota Palu dalam angka 2018 yang diperoleh dari BPS Kota Palu. Variabel pada penelitian ini merupakan variabel yang diambil dari berbagai aspek yakni geografi, pemerintahan, sosial, transportasi, komunikasi, dan ekonomi. Adapun rincian variabel penelitiannya  adalah luas kecamatan (X1), kelurahan/desa (X2), Penduduk (X3), SD/sederajat (X4), SLTP/sederajat (X5), SLTA/sederajat (X6), fasilitas kesehatan (X7), tempat ibadah (X8), jalan aspal (X9), menara telekomunikasi/tower (X10), koperasi (X11), dan took/kios (X12). Dua belas variabel yang diteliti tersebut disederhanakan ke dalam variabel baru berupa komponen utama. Hasil analisis komponen utama menunjukkan data potensi kecamatan di Kota Palu tahun 2017 terbentuk tiga komponen utama serta dapat menjelaskan varian data secara keseluruhan sebesar 89,98 persen.
MONITORING VARIABILITAS PROSES BERDASARKAN STATISTIK WILKS
Authors: Barlian Sari Suci , Tri Herdiani Erna , Sirajang Nasrah
Published: July 2019

In a manufacturing industry quality problems often occur. One of the main cause is due to variability process. Variability process is a variation that occurs in the process, both in manufacturing and non-manufacturing processes. One method for monitoring variabiliti process is by using Wilks Statistics. Wilks statistics is a method that is used based on individual observations. This study aims to monitor the variability of the process and apply it to Electric Resistance Welded (ERW) pipes with the Wilks statistical method. In addition, a capability process analysis is also carried out when the Wilks control chart has been controlled. The result showed that all observations carried out individually were in control limit with a capability process of  2.5386, which means the process capability of ERW pipe production using a multivariate Wilks statistical control chart was capable and match  with the specifications limit specified by company.
PENGEMBANGAN MODUL BERBASIS DAERAH TRENGGALEK UNTUK MENUMBUHKAN SIKAP PEDULI LINGKUNGAN
Authors: Rozhana Kardiana Metha
Published: July 2019

The teacher's difficulties in teaching are weaknesses in preparing thematic lesson plans and the lack of adequate learning resources for students. The purpose of this development and research is to provide facilities and new innovations for elementary school teachers in developing module teaching materials. The hope is that this module can be used as an additional supplement for students and as an effort to apply environmental awareness as found in character education. This study used the research and development method of Borg & Gall. The results of the feasibility validation from the experts showed that the percentage of 89.4% was feasible. While aspects of the application of teachers and students of module products through questionnaires showed an average percentage of 92.5% with very good criteria and could be used without revision. While the effectiveness of modules is seen from two aspects, namely learning outcomes with a mean percentage of 95.2% showing complete learning and learning activities showing active information with a percentage of 77.4%. While the value of environmental care attitude shows a percentage of 3%, namely a good attitude towards the environment of residence.

Kesulitan guru dalam mengajar yaitu kelemahan dalam menyusun RPP tematik dan kurangnya sumber belajar yang memadahi bagi siswa. Tujuan pengembangan dan penelitian ini yaitu memberikan kemudahan dan inovasi baru bagi guru SD dalam mengembangkan bahan ajar modul. Harapannya modul ini dapat dijadikan suplemen tambahan bagi siswa dan sebagai upaya menerapkan sikap peduli lingkungan sebagaimana yang terdapat dalam pendidikan karakter. Penelitian ini menggunakan metode penelitian dan pengembangan Borg & Gall. Hasil validasi kelayakan dari para ahli menunjukkan persentase 89,4% layak digunakan. Sedangkan aspek keterterapan guru dan siswa produk modul melalui angket menunjukkan persentase rata-rata 92,5% dengan kriteria sangat baik dan dapat digunakan tanpa revisi. Sedangkan keefektifan modul dilihat dari dua aspek yaitu hasil belajar dengan persentase rerata 95,2% menunjukkan pembelajaran tuntas dan aktivitas belajar menunjukkan keterangan aktif dengan persentase 77,4%. Sedangkan nilai sikap peduli lingkungan menunjukan persentase 3% yaitu sikap baik terhadap lingkungan tempat tinggal.
PENGGUNAAN MEDIA KARTU ANGKA UNTUK PENINGKATAN KEMAMPUAN PENGENALAN NUMERIK PADA ANAK AUTIS
Authors: Husen Sabaruddin Dahlan
Published: July 2019

Salah satu tujuan pembelajaran matematika bagi anak autis adalah mengenal dan menulis bilangan asli sampai angka 80 dengan menggunakan benda konkret. Oleh karena itu, pembelajaran di kelas sepatutnya menggunakan media ajar yang mampu mewujudkan materi abstrak ke bentuk lebih nyata yang dapat diamati oleh siswa. Kartu angka merupakan salah satu media sederhana siap pakai yang dapat dimanfaatkan pada proses pengenalan angka. Tujuan penelitian ini adalah untuk mendeskripsikan bagaiman penggunaan media kartu untuk pengenalan angka bagi anak autis dan implementasi pola permainan media kartu untuk mengenalkan angka pada anak autis. Penelitian deskriptif dipilih sebagai metode penelitian. Instrumen yang digunakan berupa teknik observasi langsung. Hasil penelitian menunjukkan bahwa media kartu efektif digunakan pada anak autis untuk mengenalkan angka dan pola permainan media kartu mengikuti sintaks picture and picture. Sehingga disarankan agar guru dan orang tua dapat mengkombinasikan media kartu dengan sintaks picture and picture untuk mengenalkan angka sebagai stimulus pembelajaran matematika anak autis.
Menelisik Pajak Penghasilan Atas Bisnis Online Shop
Authors: Viana Elisabeth Ria , Margareth Paulina , Serly -
Published: July 2019

This research is motivated by the large number of online shops these days which make question about the entrepreneur of online shop’s obedience onto their tax obligation. This study aims at exploring the entrepreneur of online shop’s tax comprehension and how it is applied for their income. In order to interpret and understand the relationship between income tax and online shop business form used interpretative paradigm as a research methodology. Interpretative paradigm is considered able to interpret the experience and the awareness on the income tax of online shop. From this study it was found that tax is considered as an obligation, deadweight, and a complicated case. There is an opinion that owning convensional shop give more awareness to the entrepreneurs to pay the tax rather than owning online shop. In addition this study successfully traced that some of the interviewees with their knowledge and their realiziation using online shop to avoid tax that might leads to be applied on their income. Online shop is used as a way to hide their income due to the unmonitored and there is no specific constitution about this case.

 

Penelitian ini dilatarbelakangi oleh maraknya usaha online shop saat ini yang juga menimbulkan pertanyaan tentang ketaatan pengusaha online shop atas kewajiban pajaknya. Penelitian ini bertujuan untuk menyelidiki pemahaman pajak bagi pengusaha online shop dan aplikasinya dalam penghasilan mereka. Dalam rangka memaknai dan memahami kembali keterkaitan antara pajak penghasilan dan usaha online shop, digunakan paradigma interpretatif sebagai metodelogi penelitian. Paradigma interpretatif dianggap mampu memaknai pengalaman dan kesadaran atas pajak penghasilan dan usaha online shop. Dari penelitian ini ditemukan bahwa pajak dianggap sebagai kewajiban, beban, dan hal yang sulit. Ada pandangan bahwa kepemilikan toko secara konvensional jauh lebih mendorong pengusaha untuk membayar pajak jika dibandingkan dengan kepemilikan online shop. Selain itu, penelitian ini berhasil menemukan bahwa ada beberapa informan yang dengan pengetahuan dan kesadaran mereka menggunakan online shop untuk menghindari pajak yang bisa dikenakan atas penghasilan mereka. Online shop digunakan sebagai cara untuk menyembunyikan penghasilan mereka karena pengenaan paj aknya yang belum ketat dan belum ada Undang-Undang khusus terkait hal itu.
THE FACTORS AFFECTING TENDENCY OF FRAUD IN GOVERNMENT SECTOR
Authors: Lestari Elinda Bayu , Tarjo - , Prasteyono -
Published: July 2019

The purpose of this study is to explore perception of government officials in government agencies about the effects of morality of individuals, organizational culture, and leadership style on tendency of fraud. This study is a quantitative research using a survey which collected main data from the samples by using questionnaire. This research was analyzed with Multiple Linear Regression Analysis. The respondents of this research were the Subsection Head of Finance and Expenditure Treasurer. The findings indicate that morality of individuals has no significant effect on tendency of fraud, while organizational culture and leadership style have a significant negative effect on tendency of fraud.

Tujuan penelitian ini adalah untuk menggali persepsi para pegawai pemerintah di instansi pemerintahan mengenai pengaruh moralitas individu, budaya organisasi, dan gaya kepemimpinan terhadap kecenderungan fraud. Penelitian ini menggunakan metode kuantitatif dengan cara survei yakni mengumpulkan data pokok dari suatu sampel dengan memakai instrumen kuesioner. Penelitian ini dianalisis dengan menggunakan Analisis Regresi Linier Berganda. Responden penelitian adalah kepada Kasubbag Keuangan dan Bendahara Pengeluaran. Hasil penelitian menunjukkan bahwa moralitas individu tidak berpengaruh signifikan terhadap kecenderungan fraud, sedangkan budaya organisasi dan gaya kepemimpinan berpengaruh negatif signifikan terhadap kecenderungan fraud.
HUMAN DEVELOPMENT INDEX AND AUDIT OPINION
Authors: Nor Wahyudin , Hudaya Muhammad , Novriyandana Rifqi , Lesmanawati Dewi , Yuliastina Melllani
Published: July 2019

This study aims to investigate: the influence of human development indeks (HDI) and growth of HDI on auditor opinion and the difference between the level of HDI entities that get the predicate of qualified opinion or non qualified opinion. The data of this research comprise 1.482 out of 496 regency/cities governments in Indonesia during 2014-2016. The analysis techniques used are multiple regression and independent simple t test. The results of this study show that the human development indeks has influence on auditor opinion, the growth of human development indeks has influence on auditor opinion. The results of this study also found that the average performance of HDI between regency/ cities in Indonesia is different between of qualified opinion or non qualified opnion.
Oxidation Behavior of Zr-based Amorphous Alloys at 400˚- 450˚C in Air
Authors: Triwikantoro Triwikantoro , Pribadi Romdhoni Graha , Munawaroh Fatimatul
Published: July 2019

The study of oxidation behavior of amorphous alloys based on Zirconium with 2 variations in composition was carried out: Zr64.5Cu17Ni11Al7.5 and Zr69.5Cu12Ni11Al7.5 at temperatures of 400 - 450˚C in air. Amorphous Zr-based alloys were thermally characterized using Differential Scanning Calorimeter (DSC) to determine the crystallization temperature and glass transition temperature. The oxidation characterization was carried out using a Thermo gravimetric Analyzer (TGA) at temperatures of 400, 425, and 450˚C for 4 hours in air. The phase analysis of the oxidation product was identified using X-Ray Diffaction (XRD). Based on DSC data the crystallization temperature for Zr64.5Cu17Ni11Al7.5 and Zr69.5Cu12Ni11Al7.5 is 426 and 442˚C respectively. The oxidation kinetics of the two alloys follow parabolic law and the oxidation rate increases with the addition of temperature. Oxides formed during isothermal oxidation in the Zr64.5Cu17Ni11Al7.5 and Zr69.5Cu12Ni11Al7.5 alloys are t-ZrO2 (tetragonal) as the dominant phase and ZrO2 (monoclinic) and CuO as the minor phase. The intermetallic phase is also formed in both samples, t-Zr2Ni and Zr2Cu.
Festival Air (Songkran): Komodifikasi Budaya di Thailand
Authors: Niko Nikodemus , Atem Atem
Published: July 2019

This research aims to want to see the occurred on the discourse of cultural commodification of Songkran in Thailand. Songkran in Thailand is a religious and cultural festival, which is the celebration of New Year in Thailand. Culture of Songkran festival which then becomes bringing many foreign tourists come to some areas in Thailand like Bangkok, Chiang Mai and Phuket. This great Festival and then give effect to social, cultural as well as the economy on local community. The methods used in this study is a qualitative descriptive based on the experiences both of the author. The data analyzed i.e. secondary data that comes from a variety of scientific journals, then the primary data are analyzed based on the author’s experience when on the Songkran festival in Thailand on April, 2019. Based on the analysis that the commodification of culture happens to Songkran in Thailand is not so much to erode the authenticity of rituals. This means that the core rituals such as bathing the Buddha statues in the temples still do. Commodification is a positive impact on the local community, where on area of the festival they provided tubs for sale in range 5 THB to 15 THB. Then, foreign tourists are pouring in from various countries are also effect on the local community economy.
Validation of a duplex qPCR for detection of Chlamydia trachomatis DNA in ocular samples and comparison with a direct immunofluorescence method using samples from endemic and non-endemic areas in Brazil
Authors: Favacho Joana da Felicidade Ribeiro , Leite Keren Kariene , Gomes Samara Tatielle Monteiro , Mota Gardene Dourado , Mesquita Maria da Paz Menezes , Schluga Pedro Henrique de Caires , Tassi Wallyed , Jacomasso Thiago , Farias Aline Burda , Rampazzo Rita de Cássia Pontello , Gaydos Charlotte A. , West Sheyla , Costa Alexandre Dias Tavares , Cunha Antonio Jose Ledo Alves da
Published: July 2019

Trachoma, caused by the bacteria Chlamydia trachomatis, is the world leading infectious cause of blindness. The disease is associated with poor living conditions, especially in developing countries. In these countries, diagnosis is usually based on clinical evaluation, although laboratory confirmation is necessary. Serological-based tests for trachoma laboratory confirmation are cheaper than molecular-based tests, but the later are more sensitive and specific. Among the available molecular tests, qPCR has the best cost-benefit. With this in mind, the present study developed a new duplex qPCR reaction, which concomitantly detects C. trachomatis cryptic plasmid and the human 18S rRNA gene, as an internal reaction control. The new qPCR was validated using 50 previously qPCR-characterized samples for trachoma infection, and showed 95% specificity and 100% sensitivity, with an estimated LOD95 of 600 ag/µL. Next, 50 samples from an endemic area (Marajó, Pará) and 12 from a non-endemic area (Curitiba, Paraná) were investigated using direct immunofluorescence assay (DFA) or the new duplex qPCR. Among the 50 endemic samples, three were positive by clinical evaluation (6%), 18 by DFA (36%) and 48 by qPCR (96%). All samples positive by the clinic evaluation were also positive by qPCR. From the 18 DFA-positives, qPCR identified 16 as positives as well. On the other hand, 32 samples that were DFA-negative due to the low number of elementary bodies (<5 per slide) were positive by qPCR. The results show that the new duplex qPCR has sensitivity and specificity in similar levels to commercial qPCR tests available, and that qPCR indeed is more sensitive than clinical evaluation or DFA, thus allowing earlier treatment start. The ubiquitous presence of C. trachomatis DNA in samples from the endemic region confirms that constant monitoring is necessary. Additionally, effective measures for the elimination of trachoma and the detection of bacterial DNA in the active infection are of fundamental importance, and this newly developed duplex qPCR is an important tool towards this goal.
The prediction of the crucial regulatory factors and functional analysis in pulmonary arterial hypertension by re-annotation
Authors: Li Wang , Li Xing , Hu Bing , Xia Qingqing , Ni Xiuqin
Published: July 2019

Background

Pulmonary arterial hypertension (PAH) is characterized by a progressive increase in pulmonary vascular resistance, which increases the right ventricular load and eventually leads to right ventricular failure and death. Recent theoretical developments have revealed that quiet a few lncRNAs played an important role in the development of pulmonary vascular diseases, such as H19, tcons_00034812. However, the mechanism of mRNA regulated by lncRNA in the PAH remained unclear.

Results

In our study, we re-annotated Affymetrix Murine Genome array to Human reference genome(hg38) by using the data from GENCODE database, in the light of lncRNA and mRNA. We screened differentially expressed lncRNA/mRNA between PAH samples and normal samples. Then we constructed PAH related lncRNA/mRNA co-expression network and analyzed topological properties of the network. We excavated the modules by the WGCNA R package. The genes in the modules excavated are used for enrichment analysis of functions and pathways. Finally, 8 functional modules were identified as pathogenic modules, providing new ideas for understanding the potential mechanisms of PAH.

Conclusions

We generated a new strategy to do research on pulmonary arterial hypertension. The pathogenic modules played an important role and could offer new therapeutic targets for pulmonary arterial hypertension mechanism research.
Mastery Learning improves Nursing Students’ skills The implementation of Mastery Learning method
Authors: Rabori Roghayeh Mehdipour , Nematollahi Monirsadat , Bagheryan Behnaz
Published: July 2019

Abstract
Background and purpose: Clinical education is an important part of nursing education and it is influenced by teaching methods. On the other hand, educational methods play an important role in shaping students’ basic skills and professional abilities. In order to promote clinical skills in students, the use of new clinical teaching methods seems necessary. Nevertheless, a lot of nursing instructors in Iran use traditional methods to teach nursing skills to the undergraduate nursing students in hospitals.
In this interventional study, we compared the effect of mastery learning method and common learning method on the performance of undergraduate nursing students between 2106-2018.
method
After receiving written consent, the participants were randomly divided into two groups of intervention and control. Participants' performance in five common intensive care unit (ICU) procedures (i.e. trachea and tracheostomy suction, nasogastric tube feeding, packed cell transfusion, changing set and fluid box, and changing fluid box) was assessed before and after the intervention. The assessment of participants was done by a researcher- made checklist. Data were analyzed using SPSS (version 21).
findings: No significant difference in terms of procedures performance was observed between two groups before the intervention (p>o. o5). However, paired t test showed that the scores of the intervention group before and after intervention were significantly different (p<0.05).
Conclusion: This study revealed that the implementation of mastery learning method in clinical skills training could be very effective in improving the quality of clinical learning of nursing students.
Multi-criteria decision analysis (MCDA) for surface water management plan, a case study of Kansachara sub-watershed, West Bengal, India
Authors: Bera Kartic , Banik Pabitra
Published: July 2019

The increasing demands on fresh water resources by our burgeoning population and diminishing quality of existing water resources because of pollution and the additional requirements of serving our spiraling industrial and agricultural growth have led to a situation where the consumption of water is rapidly increasing and the supply of fresh water remains more or less constant. In the context of quality, potable water is always meager for the present and future. The study is an innovative attempt towards the development of the watershed on the earth science platform. Thereafter the balancing of water resources for domestic and agricultural uses is also tried. The focus is mainly on surface water for present use and groundwater for future. This management plan especially includes socially and economically backward demographic conditions. The present study is an integrated approach for a micro-watershed development plan of the Kansachara sub-watershed.
Methods of teaching educational data mining for pedagogical students
Authors: Terbusheva E. A.
Published: July 2019

The aimof the article is to discuss and argue teaching educational data mining for pedagogical stu-dents and to describe the methodical system of educational data mining teaching for students with a middle level of mathematical and IT disciplines, that contributes to the development of student’s research competence. The relevance of the study is determined by the requirements for the ability of higher education graduates to analyze information and perform research using modern methods and technologies that are mentioned in the educational standards and the government order. They are associated with an increasing amount of accumulated data in various fields and the cost of the knowledge extracted from data.

Materials and methods.The article describes the author’s methodical system of educational data mining teaching, which was developed rely on: analysis of requirements and expectations to the re-search competence level, data analysis skills and modern education in general; comparison and analysis of the content of educational programs, books and courses on data mining and related dis-ciplines, generalization of pedagogical experience. The main aspects underlying the methodology: a form of flipped learning, a concentric (iterative) content structure, research teaching methods, a set of practical tasks for developing research competencies and Weka software for data mining as the main technical training tool for practical tasks implementation. The effectiveness of the developed methodological system was tested by the educational process monitoring, students questioning and statistical processing of questionnaires data.

Results.The study shows the relevance of educational data mining teaching for students of peda-gogical universities, studying in mathematical and informational specialization. The use of the de-scribed methodic system for senior pedagogical students allows increasing the level of research competence of students and significantly developing the competence of data analysis.

Conclusion.The described methodical system can used be partially or completely by teachers and methodologists for teaching data analysis at the modern level and development of research compe-tence of students with an average level of knowledge in mathematical and IT disciplines.
Targeted Drug Delivery of Teniposide by Magnetic Nanocarrier
Authors: Kakaei Saeed , Khameneh Elham Sattarzadeh , Ghasemi Effat , Aghazadeh Mustafa
Published: July 2019

Background::

Drug delivery technologies adjust drug release profile, absorption, distribution,
and elimination for benefiting to the improvement of product efficacy, effectiveness, and safety.
The IONPs release drugs via enzymatic activity, changes in physiological conditions such as pH,
osmolality radiation, or temperature. In the case of nanoparticles that respond to the magnetic stimulus,
the drug directs its action towards the site of a detected magnetic field.

Objective::

In this study, the synthesis of a specific drug-delivery system based on magnetic nanocarrier
for teniposide as an anticancer drug is reported. The iron oxide@SiO2 core-shell nanoparticles
were functionalized with APTS as a spacer then coupling to the DOTA molecules. Anticancer drug
of teniposide conjugated to the acidic group of DOTA via an amide bond. Multi-purpose magnetic
nanoparticles were synthesized for targeted delivery of teniposide.

Methods:

Iron oxide nanoparticles were firstly coated with silica and their surface was then modified
with aminopropyltriethoxysilane (APTES) through an in situ method. DOTA-NHS was also coupled
to Fe3O4@SiO2-APTES via an amide bond formation. In the final step, teniposide as an anti-cancer
drug was conjugated with DOTA through ester bonds, and the final compound of Fe3O4@SiO2-
APTES-DOTA-Teniposide was obtained. The obtained nanocarrier was evaluated by various analyses.

Results::

The multifunctional Fe3O4@SiO2-APTES-DOTA nanocarriers were successfully synthesized
and characterized by XRD, FTIR, TGA, and UV-vis techniques. The silica-coated magnetic
nanoparticle functionalized with aminopropyl triethoxysilane (APTES) was reacted with an acid
group of DOTA, and teniposide was then coupled to DOTA through ester formation bonds. Drug
release experiments showed that most of the conjugated teniposide were released within the first 12h.

Conclusion::

The fabricated nano-carriers exhibited pH-sensitive drug release behavior, which can
minimize the non-specific systemic spread of toxic drugs during circulation whilst maximizing the
efficiency of tumor-targeted anticancer drug delivery for this purpose. The prepared teniposidegrafted
Fe3O4@SiO2-APTES-DOTA core–shell structure nanoparticles showed a magnetic property
with exposure to magnetic fields, indicating a great potential application in the treatment of cancer
using magnetic targeting drug-delivery technology and multimodal imaging techniques.
John Farrell, The Varieties of Authorial Intentions: Literary Theory Beyond the Intentional Fallacy (Palgrave Macmillan, 2017)
Authors: Kiparski Frederik
Published: July 2019

John Farrell, The Varieties of Authorial Intentions: Literary Theory Beyond the Intentional Fallacy. Palgrave Macmillan, 2017.
Implementation of CPPB-IRT, WISE, and Halal Guarantee System on Bread Production
Authors: Suhardi Bambang , Putri Nabilla Indah , Astuti Rahmaniyah Dwi
Published: July 2019

Bread is food that many consumed in Indonesia. It usually consumed and a substitute for rice. PT. X is an Indonesian company that produces dry bread and wet bread. The company must implement a Good Manufacturing Process (GMP) and Halal Guarantee System (HGS) to ensure the food safety that the company produced. The company is also obliged to pay attention to Occupational Safety and Health in the work environment by applying WISE. This study consists of five staged. The stages include identification of the condition of the company, CPPB inspection, WISE examination, HGS inspection, and proposed improvements in the production process. The results of the study show some elements that have not been fulfilled. These elements include 6 CPPB elements, 9 WISE elements, and 8 HGS elements. The results of the study also provided several studies. Some of the recipients were improvements in the Standart Operational Procedure (SOP) for the receipt and receipt of materials, and the SOP for the receipt and receipt of industrial non-processed materials.
APLIKASI KOMPOS TANDAN KOSONG KELAPA SAWIT PADA TANAMAN KARET MENGHASILKAN
Authors: Saputra Jamin , Stevanus Charlos Togi
Published: July 2019

Tandan kosong kelapa sawit merupakan limbah terbesar dibandingkan limbah padat lainnya di perkebunan kelapa sawit. Sekitar 23% dari tandan buah segar menjadi tandan kosong kelapa sawit. Hal tersebut merupakan potensi yang besar untuk bahan baku pembuatan kompos.Tujuan penelitian ini adalah untuk mengetahui pengaruh penggunaan kompos dari tandan kosong kelapa sawit dan kombinasinya dengan pupuk kimia terhadap pertumbuhan dan produksi pada tanaman karet menghasilkan. Penelitian dilakukan di Kebun Percobaan Balai Penelitian Sembawa dari tahun 2014 sampai 2016. Penelitian dilaksanakan dengan menggunakan tanaman karet klon PB 260 dengan tahun tanam 2001. Penelitian menggunakan Rancangan Acak Kelompok (RAK) yang terdiri atas 6 perlakuan, 4 ulangan dan setiap ulangan terdiri atas 49 tanaman. Perlakuan yang diuji terdiri atas: (1) Kontrol (tanpa pemupukan), (2) 100% dosis umum pupuk kimia, (3) 2 kg kompos, (4) 1,6 kg kompos + 25% dosis umum pupuk kimia, (5) 1,2 kg kompos + 50% dosis umum pupuk kimia, (6) 0,8 kg kompos + 75% dosis umum pupuk kimia. Pengamatan dilakukan terhadap kandungan hara tanah dan tanaman, pertumbuhan lilit batang, tebal kulit pulihan, dan produksi tanaman selama dua tahun. Hasil penelitian menunjukkan bahwa perlakuan kompos 1,2 kg+50 % dosis umum berpengaruh nyata terhadap pertumbuhan lilit batang dan produksi tanaman karet. Penggunaan kompos dengan dosis 1,2 - 1,6 kg mampu menurunkan penggunaan pupuk kimia sebesar 50 - 75%.
Climate change skeptics teach climate literacy? A critical discourse analysis of children's books
Authors: Colston Nicole , Thomas Julie
Published: July 2019

This critical discourse analysis examined climate change denial books intended for children and parents as examples of pseudo-educational materials reproduced within the conservative echo chamber in the United States. Guided by previous excavations in climate change denial discourses, we identified different types of skepticism, policy frames, contested scientific knowledge, and uncertainty appeals. Findings identify the ways these children's books introduced a logic of non-problematicity about environmental problems bolstered by contradictory forms of climate change skepticism and polarizing social-conflict frames. These results pose pedagogical dilemmas for educators, environmental advocates, and communication experts interested in advancing understanding and action in the face of rapid climate change.
URGENSI PENGEMBANGAN KURIKULUM PROGRAM STUDI PENDIDIKAN KIMIA UIN AR- RANIRY
Authors: Abdullah Ramli
Published: July 2019

Urgency curriculum development education courses chemistry Faculty of Tarbiyah and Teaching UIN Ar-Raniry Banda Aceh. Implementation of this research aims to be known: (1) How is the curriculum of Chemical Education Program currently in use, and (2) How is the curriculum of Chemical Education Program that is relevant to the times now. The research was conducted at the Basic Education Program Chemistry Faculty of tarbiyah UIN Ar-Raniry Banda Aceh in April to September 2013. The method used in this research is qualitative descriptive, the population in this study is a faculty, alumni, and students of Chemistry Education Tarbiyah UIN Ar-Raniry Banda Aceh. Retrieving data using instruments interviews with faculty, students, and alumni of Basic Chemical Education Program Faculty of tarbiyah UIN Ar-Raniry Banda Aceh. While the curriculum documentation talaah Basic Chemical Education Program Faculty of tarbiyah UIN Ar-Raniry Banda Aceh and curriculum Document Basic Chemical Education Program FKIP Unsyiah Banda Aceh. The results obtained in this study are: (1) Get a picture of the curriculum of Chemical Education Program currently in use, and (2) Chemistry Education Program curriculum that is relevant to the times now for the Basic Education Program Chemistry Faculty of tarbiyah UIN Ar Raniry Banda Aceh. The conclusion of this study is mengatahui picture of Chemical Education Program curriculum currently in use, and the curriculum of Chemical Education Program are relevant to the development of today for Basic Chemical Education Program Faculty of tarbiyah UIN Ar-Raniry Banda Aceh. Suggestions put forward of this research is to improve the quality of learning in Chemistry Education Program requires continuous curriculum development, improving the quality of teachers and increase motivation and interest in students' growth Study Program Basic Chemistry Faculty of tarbiyah UIN Ar-Raniry Banda Aceh.
PENERAPAN MODEL PEMBELAJARAN KOOPERATIF TIPE TPS DI SMA NEGERI 12 BANDA ACEH
Authors: Emda Amna
Published: July 2019

Students are studying subjects that are required to play an active role in learning activities. The way that can be done to enable such students through the implementation of cooperative learning model, one of which is TPS. TPS application of cooperative learning in the learning of chemistry can stimulate students to express opinions or ideas, mutual cooperation, respect the opinions of others, helping to solve problems and develop students' creativity. Active student involvement in learning will lead to learning motivation that will have an impact on the improvement of learning outcomes
Kontektualisasi Direct Instruction Dalam Pembelajaran Sains
Authors: Zahriani Zahriani
Published: July 2019

Direct Instruction is one teacher teaching model is centered on the center or teacher. This learning model emphasizes the delivery of content is done verbally by the teacher to the learner. In the implementation of this model has the characteristic form of the five phases of a very important activity in the form of submission of the learning objectives, demonstrate knowledge and skills, guiding the training, checking understanding and provide feedback and provide advanced training and implementation. Research conducted on the use of the model of Direct Instruction in science learning so far shown significant results to increase students' understanding of science concepts. Direct Instruction is still relevant models used to study the science of materials that explain concepts and procedural and can be combined with other learning models, the use of the media is to help the implementation of the Direct Instruction model study
PENGEMBANGAN MEDIA AUDIO VISUAL TENTANG PRAKTIKUM REAKSI OKSIDASI REDUKSI DAN ELEKTROKIMIA SEBAGAI MEDIA PEMBELAJARAN MANDIRI BAGI SISWA SMA/ MA KELAS XII SEMESTER 1
Authors: Purba Asmara Anjar , Dwi Ananto Agus , Riyanto Nokman
Published: July 2019

The research is aimed to develop media of chemistry learning which based on technolgy and information esspecially for student of SMA/ MA grade XII semester I and to determine the value of quality of the media by scoring from chemistry teacher in SMA Yogyakarta Regency. The process of developing media through reviewing by learning media expert and also by peer reviewer. The instument for evaluating to the media is questioner which containing several aspects and criteria of evaluation and scoring. The scoring had done by five chemistry teachers of SMA/ MA in Yogyakarta Regency. There are eight aspects of evaluation and scoring with thirty six indicator of scoring items. The form of the result of evaluation is qualitative data that must be converted into quantitative data for determining of the mediaâ€™s quality. The product of the research is media audio visual for practicum of oxidation reduction reaction and electrochemistry for student of SMA grade XII semester 1. The components of the product are using guidance to the media, student activity part, evaluation part, the answer of student activity, and also the profile of the researcher. Based on evaluation and scoring from the teachers, the media is reached level of quality as very good level with average score as much as 145.52 where the ideal score is 144. Based on the research, the media could be used to help student to learn chemistry in SMA/MA grade XII semester 1 chapter oxidation and reduction reaction and electrochemistry