bluuebunny/crossref_metadata_2025 huggingface dataset:
Riesgos de la brecha digital de género entre los y las adolescentes
Authors: Masanet Maria-Jose , Pires Fernanda , Gómez-Puertas Lorena
Published: February 2021

The gender digital divide between teens from seven countries in Europe, in Australia, and in countries of South America through a socio-cultural perspective is analyzed. The article compares which habits of use and consumption are attributed and performed by adolescents in multiple media and social media, and explores if these uses are grounded in the historically established gender roles. The data come from the Transmedia literacy research project (2015-2018) that had two main objectives: to explore what are teens doing with media and how have they learned to do it. An ethnographic approach was used, combining various research methods as questionnaires, interviews and participant observation, among others. In this article we focus on the analysis of the questionnaire implemented to map teens’ habits of use and consumption (N=1,520). To respond to the objective of the article, a descriptive univariate and bivariate analysis was carried out. The results show that the digital gender divide still exists and it takes shape through the persistence of gender stereotypes and roles associated to men and women and their relationship with media such as videogames practices (associated with boys) and the creation of stories (associated with girls).

Resumen
Se analiza la brecha digital de género entre adolescentes de siete países de Europa, en Australia y países de Sudamérica a través de una perspectiva socio-cultural, comparando qué hábitos de uso y consumo son atribuidos y desempeñados por adolescentes en los múltiples medios y redes sociales y si ellos se enmarcan en roles estereotipados de género. Los datos se extraen del proyecto de investigación Transmedia literacy (2015-2018), que tenía cómo objetivos principales explorar qué están haciendo los adolescentes con los medios y cómo aprendieron a hacerlo. Para ello, se realizó un acercamiento etnográfico utilizando varios métodos de investigación como cuestionarios, entrevistas y observación participante, entre otros. En ese artículo nos centramos en el análisis del cuestionario implementado para mapear los hábitos de uso y consumo mediático de los adolescentes (N=1.520). Para responder a los objetivos del artículo se ha llevado a cabo un análisis descriptivo univariante y bivariante. Los resultados demuestran que la brecha digital de género sigue existiendo y que toma forma a través de la pervivencia de estereotipos de género y de roles asociados a los hombres y mujeres y su relación con las tecnologías y medios de comunicación, como es el caso de los videojuegos (asociados a los chicos) y de la creación de relatos (asociado a las chicas).
Stirring effect on zeolites synthesis with different Si/Al molar ratios Using 1-Butyl-3-methylimidazolium chloride as structure-direct agent
Authors: L. Mignoni Marcelo , De Aguiar Pedott Victor , S. Z. Battiston Catia , E. Demaman Oro Carolina , O. de Souza Michele , B. C. Pergher Sibele , Marcos Dallago Rogério , F. de Souza Roberto , Bernardo-Gusmão Katia
Published: February 2021

Different types of zeolites could be synthesized changing the variables in the synthesis process. This paper studies the stirring effect on zeolites synthesis at different Si/Al molar ratios (1, 8, 20, 50 and 120) using the ionic liquid 1-butyl-3-methylimidazolium chloride (BMI.Cl) as structure-direct agent. The results suggest that the ionic liquid BMI.Cl would be a highly effective directing agent for the crystallization of zeolites type A, ZSM-5, Beta and ZSM-35. The stirring effect on compositional and morphological parameters seems to be signiﬁcant. Therefore, ternary composition diagrams were plotted for the static and stirring conditions,  showing the influence of stirring on the composition and morphology of the generated materials. It was possible to verify, in the ternary diagrams, the conditions for obtaining the pure ZSM-5 and ZSM-35 zeolites, as well as the different morphologies found for the same regions, when the zeolites were synthesized under static and stirring conditions. It is also observed that the zeolites ZSM-35 and Beta show a greater amount of Al2O3 (4 mol% and 1.6 mol%) only when the reaction is carried out under stirring conditions.
Avaliação de sucos de laranja artesanais produzidos na Microrregião de Erechim
Authors: Dallago Rogério Marcos , Pascuetti Tres Bethina , Denti Andressa Franco , Oro Carolina Elisa Demaman , Dornelles Venquiaruto Luciana
Published: February 2021

O suco de laranja tem ganhado cada vez mais espaço no consumo diário da população. Esse fato se deve às suas características sensoriais, propriedades antioxidantes e ao alto teor de vitamina C. Neste sentido, o objetivo do presente estudo foi analisar físico-quimicamente dez amostras de sucos de laranja artesanais, produzidos na microrregião de Erechim/RS. Para tanto, foram realizadas análises de teor de vitamina C (ácido ascórbico), pH, acidez total, sólidos solúveis totais (SST), sólidos totais (ST), índice de maturação, umidade e cor, os quais foram comparados com a legislação vigente. Em relação à caracterização físico-química, todos as amostras analisadas atenderam à legislação em relação aos parâmetros vitamina C, SST (em °Brix), acidez em g/100g e cor. A variação de pH e acidez sugerem que os sucos são produzidos com diferentes variedades de laranjas. Os resultados, principalmente em relação ao teor de vitamina C, confirmam a importância nutricional deste suco, o qual se apresenta como uma alternativa saborosa e saudável para a população.
Pengaruh Media Puzzle Bola Terhadap Kemampuan Mengenal Warna Pada Siswa Tunagrahita Sedang Kelas III di SDLB Bhakti Luhur Jember
Authors: Ase Agustina
Published: February 2021

Penelitian ini menggunakan kuantitatif  metode eksperimen Single Subject Research (SSR), dapat dilakukan sebanyak 2 minggu yaitu tahap baseline 1 minggu dan intervensi 1 minggu. Subyek penelitian adalah siswa tunagrahita sedang kelas III yang berinisial KA. Pada fase baseline hasil penelitian menunjukkan KA mendapatkan skor persentasenya 41%, 41%, 50%, 50% dan 41% dan setelah memasuki minggu kedua siswa diberikan intervensi oleh peneliti sehingga skor yang diperoleh siswa meningkat yaitu 69%, 75%, 75%, 72% dan 77%. Dari hasil penelitian ini dikatakan bahwa media puzzle bola berpengaruh terhadap kemampuan mengenal warna pada siswa tunagrahita sedang kelas III di SDLB Bhakti Luhur Jember
Breastfeeding Self Efficacy Ibu Post Seksio Saesarea
Authors: Mardiyaningsih Eko , Purwaningsih Heni , Galih Widodo Gipta
Published: February 2021

The one factor that causes mothers to stop breastfeeding is low self- efficacy. The lowest breastfeeding self-efficacy causing the mother to stop breastfeeding too quickly even at the beginning after giving birth to the mother breastfeeding her baby. The goal of this study is to determine the scale of Breastfeeding Self Efficacy in mothers with cesarean childbirth. Descriptive research type, sampling technique with purposive sampling with criteria mothers who give birth with cesarean section, do not experience complications after childbirth and are eager to become respondents. This type of research was descriptive with a purposive sampling technique, the criteria were mothers who gave birth by cesarean section, did not experience postpartum complications, and willing to be respondents. The sample in this study was 52. The study used the Breastfeeding Self Efficacy Scale to explore breastfeeding self-efficacy. Data analysis used univariate analysis in the form of frequency and proportion distributions. The results indicated that most respondents who had a high BSE score were the high-risk age group (56.3%), worker (54.2%), tertiary education (62.5%), breastfeeding experience (51.6%), multipara (53.3%). To increase BSE score, it is necessary to promote breastfeeding so that it is hoped that it will increase the duration of exclusive breastfeeding
Kombinasi Dzikir Dan Relaksasi Otot Progresif Terhadap Tingkat Insomnia Pada Lansia
Authors: Amal Ahmad Ikhlasul - , Cahyaningtias Yulianti , Suyanto Suyanto
Published: February 2021

Insomnia merupakan suatu ketidakmampuan memperoleh secara cukup kualitas dan kuantitas tidur. Hal tersebut dapat menyebabkan beberapa masalah pada lansia diantaranya rasa kantuk disiang hari, letih, dan kurang berkonsentrasi. Penanganan insomnia dengan menggunakan terapi farmakologi dan non farmakologi. Terapi kombinasi dzikir dan relaksasi otot progresif adalah salah satu bentuk terapi non farmakologi yang dapat menangani insomnia. Tujuan penelitiian ini yaitu untuk mengetahuii pengaruh kombinasi dzikir dan relaksasii otot progresiff terhadap tingkatt insomnia pada lansia di rumah pelayanann sosiall lanjut usia.

Penelitian ini adalah penelitian kuantitatif dengan desain Quasi eksperimen without control group (pre eksperimen). Teknik pengambilan sampel dengan purposive sampling dengan jumlah responden 22 orang. Analisis data yang digunakan adalah uji Marginal Homogenity.

Berdasarkan analisa hasil penelitian sesudah diberikan terapi kombinasi diperoleh nilai kategori tidak ada keluhan 12 responden (54,5%) dan kategori ringan 10 responden (45,5%).

Ada pengaruh pemberian kombinasi dzikir dan relaksasi otot progresif terhadap tiingkat insomnia pada lansia di rumah pelayanan sosiall lanjutt usia hasil p value sebesar 0,0001 (p value < 0,05).
COMPLIANCE TO MEDICATION IN HYPERTENSIVE PATIENTS OF CHRONIC DISEASE MANAGEMENT CONSULTING PHARMACIST AT PUBLIC HEALTH CENTER OF SEMARANG CITY
Authors: Pranata Meki , Marswita Rino Arianti , Sabiti Farrah Bintang
Published: February 2021

One of the pharmaceutical services that can be done by pharmacists is counseling. Counseling lead to increase the obedience to taking medication in reduce hypertension. The objective of this research is to evaluate the obedience to drug therapy of hypertensive patient which already get counseling by pharmacists in Public Health Center in Semarang. This research was carried out by cross sectional design. The research was conducted towards 40 patients who were willing to take part in the research by filling out inform consent. “Pill count” method was used to evaluate the obedience level by counting the remaining drug for 1 month starting from the beginning until the end of July 2019. These results will be analyzed by chi-square test to determine the relationship between the characteristics and the obedience level. Wilcoxon test was done to determine the differences in groups before and after given counseling. The results showed that there was a significant decrease in systolic and diastolik pressure (p = 0,000). Chi-square test results showed that counseling given by pharmacists had no significance effect related to the obedience to drug therapy of hypertensive prolanis patient with a statistic of p> 0.05.
ANTIDIABETIC ACTIVITY FROM TABLETS EFFERVESCENT EXTRACT OF MIMOSA PUDICA LINN LEAVES
Authors: Azizah Na'ilatul , Januarti Ika Buana , Masithoh Annisa , Nisa Anna Khoirun
Published: February 2021

The community has trusted mimosa pudica linn as an alternative antidiabetic treatment. Compounds that have antidiabetic activity in Mimosa pudica linn are flavonoids, alkaloids, and tannins. The selection of effervescent tablet dosage formulations is practical for diabetics with the addition of stevia leaf sweeteners. This study aimed to determine the antidiabetic activity of effervescent tablets of Mimosa pudica linn leaves extract as a natural antidiabetic. The research method begins with the extraction of plants using the maceration method of 70% ethanol; the tablet formulation uses dry granulation. Antidiabetic activity test using 28 male mice (Mus musculus) Swiss strain divided into four groups, namely group I (negative control): Na-CMC 0.5%, group II: effervescent tablets of Mimosa pudica Linn leaves Extract dose 600 mg/kgBB, group III (positive control): metformin 65 mg/kgBB, group IV (normal control): feed and drink. Each group, except normal controls, was induced by DM using alloxan 150 mg/kg body weight. Data on decreased blood glucose levels were analyzed using the Kruskal-Wallis statistical test the study results show that effervescent tablets meet the parameters of disperse time test, pH test, size uniformity test, weight uniformity test, hardness test, moisture test, and friability test. This study concludes is that there is a significant difference between the negative, positive, normal, and treatment control groups, which means that the administration of effervescent tablets of 70% ethanol extract of Mimosa pudica Linn leaves at a dose of 600 mg/kgBB can reduce blood sugar levels in mice (Mus musculus).
First record of Hishimonus sellatus (Uhler, 1896) from Russia (Homoptera: Cicadellidae: Deltocephalinae)
Authors: Gnezdilov V.M.
Published: February 2021

Hishimonus sellatus (Uhler, 1896) is recorded from Russia (Krasnodar Territory) for the fi rst time.
New species of the genus Sagitta sensu str. (Chaetognatha) from the Sea of Japan with description of an original staining and dissection technique
Authors: Kassatkina A.P.
Published: February 2021

A detailed description, figures of a new species Sagitta sublica sp. nov. and the original techniques of research are presented. A key of species and subspecies of the world fauna of the Sagitta sensu str. Quoy et Gaimard, 1827 (for individuals at maturation stages III-V) is done.
Fifth addition to the revision of Itarinae (Orthoptera: Gryllidae)
Authors: Gorochov A.V.
Published: February 2021

Itara (Phormincter) ivanovi sp. n. from South Malacca is described. Some recent publications on taxonomy of Itarinae are briefl y discussed.
Three new species of the genus Smittina from the Weddell Sea, Antarctic (Bryozoa: Cheilostomata: Smittinidae)
Authors: Gontar V.I.
Published: February 2021

New species Smittina multanguloporata, S. humilis, and S. impellucida collected in the Weddell Sea by the German Antarctic Expedition ANT XIII/3 on research vessel “Polarstern” in 1996 are described. The genus Smittina, with 12 Arctic and 16 Antarctic species, has a bipolar distribution.
UNITED STATES FOREIGN POLICY TOWARDS SOUTH ASIA; ANALYZING IMPLICATIONS FOR PAKISTAN
Authors: Ishaque Waseem
Published: February 2021

The US foreign policy for South Asia has generally remained zero-sum for India and Pakistan. While Pakistan joined US camp immediately after independence and during the period of cold war remained part of the US alliance system and frontline state in the defeat of communism and now War on Terrorism. On the contrary, the US adopted a different approach towards India in terms of strategic partnership and different nuclear-related cooperation. US National Security Strategy of January 2018 has reprioritized national security preferences where India has been granted great status as a potential competitor of China and Pakistan has been marginalized to terrorist-related issues. The US foreign policy in its current form is perceived to be a destabilizing factor as it gives leverage to India at the cost of Pakistan. This article unveils the cardinal aspects of US foreign policy towards South Asia and its potential implications of Pakistan.
Inhibition of glioma using a novel non-neurotoxic vesicular stomatitis virus
Authors: Jiang Bin , Huang Dezhang , He Wei , Guo Wenqiang , MM  , Yin Xin , Forsyth Peter , Lun Xueqing , Wang Zhigang
Published: February 2021

OBJECTIVE

The aim of this study was to demonstrate the in vivo safety and antitumor effect of a novel recombinant vesicular stomatitis virus (VSV): G protein less (GLESS)–fusion-associated small transmembrane (FAST)–VSV.

METHODS

Viral infection efficiency and cell proliferation were detected using an inverted fluorescence microscope and alarmaBlue assay, respectively. To evaluate the safety of the virus, different doses of GLESS-FAST-VSV and a positive control virus (VSV∆M51) were injected into normal F344 rats and C57BL/6 mice, and each animal’s weight, survival time, and pathological changes were examined on the following day. To evaluate the efficacy of the virus, RG2 and GL261 cells were used to construct rat and mouse glioma models, respectively, via a stereotactic method. After multiple intratumoral injections of the virus, tumor growth (size) and the survival time of the animals were observed.

RESULTS

In vitro experiments showed that GLESS-FAST-VSV could infect and kill brain tumor cells and had less toxic effects on normal cells. After direct injection of GLESS-FAST-VSV into the animal brains, all animals tolerated the virus well, and no animal death, encephalitis, or ventriculitis was observed. In contrast, all animals that received brain injections of VSV∆M51 in the brain died. Moreover, multiple injections of GLESS-FAST-VSV in brain tumors significantly prolonged the survival of normal-immunity animals harboring brain tumors.

CONCLUSIONS

GLESS-FAST-VSV exhibited little neurotoxicity and could be injected directly into the tumor to effectively inhibit tumor growth and prolong the survival of normal-immunity animals, laying a theoretical foundation for the early application of such viruses in clinical trials.
The oncolytic Newcastle disease virus as an effective immunotherapeutic strategy against glioblastoma
Authors: Cuoco Joshua A. , Rogers Cara M. , Mittal Sandeep
Published: February 2021

Glioblastoma is the most frequent primary brain tumor in adults, with a dismal prognosis despite aggressive resection, chemotherapeutics, and radiotherapy. Although understanding of the molecular pathogenesis of glioblastoma has progressed in recent years, therapeutic options have failed to significantly change overall survival or progression-free survival. Thus, researchers have begun to explore immunomodulation as a potential strategy to improve clinical outcomes. The application of oncolytic virotherapy as a novel biological to target pathogenic signaling in glioblastoma has brought new hope to the field of neuro-oncology. This class of immunotherapeutics combines selective cancer cell lysis prompted by virus induction while promoting a strong inflammatory antitumor response, thereby acting as an effective in situ tumor vaccine. Several investigators have reported the efficacy of experimental oncolytic viruses as demonstrated by improved long-term survival in cancer patients with advanced disease. Newcastle disease virus (NDV) is one of the most well-researched oncolytic viruses known to affect a multitude of human cancers, including glioblastoma. Preclinical in vitro and in vivo studies as well as human clinical trials have demonstrated that NDV exhibits oncolytic activity against glioblastoma, providing a promising avenue of potential treatment. Herein, the authors provide a detailed discussion on NDV as a mode of therapy for glioblastoma. They discuss the potential therapeutic pathways associated with NDV as demonstrated by in vitro and in vivo experiments as well as results from human trials. Moreover, they discuss current challenges, potential solutions, and future perspectives in utilizing NDV in the treatment of glioblastoma.
Intraarterial delivery of virotherapy for glioblastoma
Authors: Srinivasan Visish M. , Lang Frederick F. , Kan Peter
Published: February 2021

Oncolytic viruses (OVs) have been used in the treatment of cancer, in a focused manner, since the 1990s. These OVs have become popular in the treatment of several cancers but are only now gaining interest in the treatment of glioblastoma (GBM) in recent clinical trials. In this review, the authors discuss the unique applications of intraarterial (IA) delivery of OVs, starting with concepts of OV, how they apply to IA delivery, and concluding with discussion of the current ongoing trials. Several OVs have been used in the treatment of GBM, including specifically several modified adenoviruses. IA delivery of OVs has been performed in the hepatic circulation and is now being studied in the cerebral circulation to help enhance delivery and specificity. There are some interesting synergies with immunotherapy and IA delivery of OVs. Some of the shortcomings are discussed, specifically the systemic response to OVs and feasibility of treatment. Future studies can be performed in the preclinical setting to identify the ideal candidates for translation into clinical trials, as well as the nuances of this novel delivery method.
Delta-24 adenoviral therapy for glioblastoma: evolution from the bench to bedside and future considerations
Authors: Ene Chibawanye I. , Fueyo Juan , Lang Frederick F.
Published: February 2021

Delta-24–based oncolytic viruses are conditional replication adenoviruses developed to selectively infect and replicate in retinoblastoma 1 (Rb)–deficient cancer cells but not normal cell with intact Rb1 pathways. Over the years, there has been a significant evolution in the design of Delta-24 based on a better understanding of the underlying basis for infection, replication, and spread within cancer. One example is the development of Delta-24-RGD (DNX-2401), where the arginine-glycine-aspartate (RGD) domain enhances the infectivity of Delta-24 for cancer cells. DNX-2401 demonstrated objective biological and clinical responses during a phase I window of opportunity clinical trial for recurrent human glioblastoma. In long-term responders (> 3 years), there was evidence of immune infiltration (T cells and macrophages) into the tumor microenvironment with minimal toxicity. Although more in-depth analysis and phase III studies are pending, these results indicate that Delta-24–based adenovirus therapy may induce an antitumor response in glioblastoma, resulting in long-term antitumor immune response. In this review, the authors discuss the preclinical and clinical development of Delta-24 oncolytic adenoviral therapy for glioblastoma and describe structural improvements to Delta-24 that have enhanced its efficacy in vivo. They also highlight ongoing research that attempts to address the remaining obstacles limiting efficacy of Delta-24 adenovirus therapy for glioblastoma.
Using viral vectors to deliver local immunotherapy to glioblastoma
Authors: Haddad Alexander F. , Young Jacob S. , Aghi Manish K.
Published: February 2021

The treatment for glioblastoma (GBM) has not seen significant improvement in over a decade. Immunotherapies target the immune system against tumor cells and have seen success in various cancer types. However, the efficacy of immunotherapies in GBM thus far has been limited. Systemic immunotherapies also carry with them concerns surrounding systemic toxicities as well as penetration of the blood-brain barrier. These concerns may potentially limit their efficacy in GBM and preclude the use of combinatorial immunotherapy, which may be needed to overcome the severe multidimensional immune suppression seen in GBM patients. The use of viral vectors to deliver immunotherapies directly to tumor cells has the potential to improve immunotherapy delivery to the CNS, reduce systemic toxicities, and increase treatment efficacy. Indeed, preclinical studies investigating the delivery of immunomodulators to GBM using viral vectors have demonstrated significant promise. In this review, the authors discuss previous studies investigating the delivery of local immunotherapy using viral vectors. They also discuss the future of these treatments, including the reasoning behind immunomodulator and vector selection, patient safety, personalized therapies, and the need for combinatorial treatment.
Clinical trials using oncolytic viral therapy to treat adult glioblastoma: a progress report
Authors: Lu Victor M. , Shah Ashish H. , Vallejo Frederic A. , Eichberg Daniel G. , Luther Evan M. , Shah Sumedh S. , Komotar Ricardo J. , Ivan Michael E.
Published: February 2021

OBJECTIVE

Adult glioblastoma (GBM) has proven refractory to decades of innovation. Oncolytic viral therapy represents a novel therapy that uses viral vectors as both a delivery and therapeutic mechanism to target GBM cells. Despite the growing body of basic science data supporting the feasibility of viral therapy to treat GBM, the reporting of clinical trial results is heterogeneous. Correspondingly, the aim of this study was to present a contemporary summary of the progress all clinical trials have made to date.

METHODS

The ClinicalTrials.gov database was reviewed in August 2020 for all possible interventional clinical trials involving viral vector–based therapy to treat adult GBM. These were then screened against selection criteria to identify pertinent clinical trials.

RESULTS

A total of 29 oncolytic viral therapy trials treating adult GBM were identified. The median start and expected completion years were 2014 and 2020, respectively. At the time of this writing, 10 (35%) trials were reported to have completed recruitment, whereas 7 (24%) were actively recruiting. The median target enrollment number was 36 (range 13–108), with the majority of trials being phase I (n = 18, 62%), and involving secondary GBM among other malignant glioma (n = 19, 66%). A total of 10 unique viral vectors were used across all trials, with the most common being adenovirus (n = 16, 55%). Only 2 (7%) phase I trials to date have reported outcomes on the ClinicalTrials.gov portal. Results of 12 additional clinical trials were found in academic publications, with median progression-free and overall survival times of 3 and 15 months, respectively, after the first viral dose at recurrence. The coordination of the large majority of trials originated from the US (n = 21, 72%), and the median number of testing sites per trial was 1 (range 1–15), via industry funding (n = 18 trials, 62%).

CONCLUSIONS

There are multiple early-stage oncolytic viral therapy clinical trials for adult GBM currently active. To date, limited results and outcomes are promising but scarce. The authors expect this to change in the near future because many trials are scheduled to have either nearly or actually reached their expected recruitment completion time. How exactly oncolytic viral therapy will fit into the current treatment paradigms for primary and secondary GBM remains to be seen, and will not be known until safety and toxicity profiles are established by these clinical trials.
Рівень адренокортикотропного гормону периферичної крові як предиктор локалізації та поширення нейроендокринних пухлин грудної клітки, що супроводжуються ектопічним синдромом Кушинга
Authors: Havrylov A.Yu.
Published: February 2021

Попри стрімкий розвиток і вдосконалення діагностичних можливостей в онкології та ендокринології діагностика синдрому неопластичного гіперкортицизму залишається однією з найскладніших та остаточно не вирішених проблем сучасної медицини. Мета — виявити можливість залежності рівня адренокортикотропного гормону периферичної крові від локалізації та поширення нейроендокринних пухлин грудної клітки, що супроводжуються ектопічним синдромом Кушинга на ранньому, пре-візуальному етапі діагностики. Матеріал і методи. Проаналізовано дані літератури, які містили інформацію про зміну рівня адренокортикотропного гормону та ступінь поширення пухлинного процесу 71 хворого із не-йроендокринними пухлинами грудної клітки. Відповідно до локалізації пухлин хворих розподілили на 3 клінічні групи. Перша група (бронхолегеневий карциноїд) включала 30 пацієнтів, із них 23 пацієнти з обмеженим пухлинним процесом; друга група (дрібноклітинний рак легень) — 4 пацієнти, усі з поширеним процесом; третя група (карциноїд/карцинома тимуса) — 37 пацієнтів, із них з обмеженим процесом 17 хворих. Показник рівня адренокортикотропного гормону в периферичній крові пацієнтів представлений у вигляді співвідношення: рівень адренокортикотропного гормону пацієнта / значення верхньої межі норми. Результати. Найвище значення рівня адренокортикотропного гормону було в групі дрібноклітинного раку легень — підвищення в 11,2±9,89 раза, натомість у групі тимом — у 7,4±7,7 раза (р<0,05), причому в підгрупі тимом обмеженої стадії рівень був дещо вищим, ніж за поширеної стадії — підвищення у 8,6±8,43 раза та 6,38±7,08 раза відповідно (р<0,05). У групі бронхолегеневого карциноїду — середнє підвищення рівня адренокортикотропного гормону в 3,28±2,54 раза в загальній групі, у підгрупі з обмеженим пухлинним процесом середній рівень адренокортикотропного гормону був вищим, ніж у групі з поширеним процесом — підвищення в 3,45±2,78 раза та 2,72±1,53 раза відповідно (р<0,05). Висновок. Отримані дані дають можливість модифікації діагностичного алгоритму в кожному конкретному клінічному випадку в пацієнтів із даною патологією, що дозволяє зробити економічно та радіологічно обґрунтований вибір подальшого діагностичного етапу.
Ассоциация укорочения длины теломер с состоянием вегетативной нервной и антиоксидантной систем у пациентов пожилого возраста с церебральным атеросклерозом и сахарным диабетом 2-го типа
Authors: Cherska M.S. , Kondratiuk V.E. , Kukharskyy V.M. , Krasnienkov D.S. , Guryanov V.G.
Published: February 2021

Количество теломер, потерянных во время каждого деления клеток, варьируется у разных людей. Предыдущие исследования показали, что увеличение окислительного стресса и хронического воспаления связаны с ускоренным укорочением теломер, однако механизм, лежащий в основе объединения укорочения длины теломер с этими факторами риска, остается гипотетическим. Целью данного исследования было определение взаимосвязи длины теломер с показателями оксидативного стресса и вариабельности ритма сердца у пациентов с церебральным атеросклерозом на разных стадиях, в том числе перенесших ишеми ческий атеротромботический инсульт, а также выявление влияния вышеуказанных факторов на прогноз укорочения длины теломер у данной категории пациентов. Материал и методы. В комплексном клинико-инструментальном исследовании приняли участие 84 пациента с церебральным атеросклерозом (ЦА) 1-3-й степени и сахарным диабетом 2-го типа (СД). Все пациенты проходили общепринятое клиническое, лабораторное и инструментальное обследование (электрокардиография (ЭКГ), МРТ головного мозга). Результаты.Пациенты были разделены на 2 группы в зависимости от относительной длины теломер. Медиана относительной длины теломер составила 2,848. Доля мужчин составила 21,2% в 1-й и 52,0% во 2-й группах. Для выявления связи показателей использовали метод построения логистических моделей регрессии. Установлена статистически значимая положительная связь риска укорочения теломер с индексом вегетативной регуляции ритма сердца (НЧ/ВЧ) и концентрацией тиобарбитурореактивных веществ (TBARs). Выводы. Изменения ВРС и TBARs у пациентов с ЦА и СД связаны с длиной теломер — маркером клеточного старения. Длина теломер может стать ранним маркером ослабления автономной регуляции сердечной деятельности и отражать истинный биологический возраст ВНС.
Морфологические изменения щитовидной железы крыс после интервального голодания
Authors: Yanko R.V.
Published: February 2021

Литературные данные относительно влияния интервального голодания на функциональную активность и, особенно, на морфологические изменения в щитовидной железе единичны. А имеющиеся сведения об его эффекте на морфо-функциональное состояние щитовидной железы часто противоречивы. Цель работы — исследовать морфологические изменения щитовидной железы взрослых крыс после воздействия интервального голодания. Материал и методы. Исследование проведено на 24 крысах-самцах линии Wistar в возрасте 15 месяцев. Подопытные крысы подвергались интервальному голоданию (1 день полное голодание / 2 дня стандартный рацион). Доступ к воде был свободным. Продолжительность эксперимента составляла 28 суток. Крыс декапитировали под легким эфирным наркозом. Работу с животными проводили в соответствии с принципами Хельсинкской декларации. Из ткани щитовидной железы изготавливали гистологические препараты по стандартной методике. С использованием цифровой камеры микропрепараты фотографировали на микроскопе «Nicon» (Япония). Морфометрию железы осуществляли на цифровых изо-бражениях с помощью компьютерной программы «Image J». Результаты. Щитовидная железа крыс после влияния интервального голодания сохраняла физиологическую структуру с четким делением на центральную и периферическую зоны. Фолликулы в ней были разной величины и имели овальную и удлиненную форму. Коллоид фолликулов щитовидной железы подопытных животных был умеренной плотности, часто имел«пенистый» характер из-за наличия многочисленных резорбцированных вакуолей. Тиреоциты подопытных крыс имели кубическую и призматическую форму. Выявлено, что в щитовидной железе крыс, находившихся на интервальном голодании, уменьшаются размеры фолликулов и коллоида, снижается внутренний диаметр фолликулов, увеличивается высота тиреоцитов, возрастает фолликулярно-коллоидный индекс, снижается индекс накопления коллоида, возрастает количество резорбцированных вакуолей в коллоиде фолликулов и количество интерфолликулярных островков. В железе этих животных выявлено уменьшение относительной площади стромы и стромально-паренхиматозного индекса, а также снижение ширины прослоек междолевой, междольковой и межфолликулярной соединительной ткани. Вывод. Влияние интервального голодания сопровождается появлением морфологических признаков активации синтетической активности щитовидной железы у взрослых крыс. Полученные данные могут представлять интерес для практической медицины при решении вопроса о назначении интервального голодания людям с пониженной функцией щитовидной железы.
О щитовидной железе: от древности до наших дней
Authors: Rybakov S.I. , Giryavenko O.Ya.
Published: February 2021

Представления о щитовидной железе восходят к глубокой древности. Однако тиреоидология — научно обоснованное учение о щитовидной железе, является сравнительно молодым разделом эндокринологии, который сформировался и получил развитие в ХІХ-ХХ ст.
Возрастные и половые различия структурно-функционального состояния сердца у пациентов с церебральным атеросклерозом и сахарным диабетом
Authors: Kondratyuk V.Ye. , Cherskaya М.S.
Published: February 2021

Цереброваскулярные заболевания — одна из важнейших причин заболеваемости и смертности среди взрослого населения. Цель исследования: сравнительный анализ морфо-функциональных изменений сердца, интракардиальной и системной гемодинамики у пациентов пожилого возраста с церебральным атеросклерозом (ЦА) 1-3 стадии и сахарным диабетом 2-го типа (СД2), в том числе в зависимости от полушарной локализации ишемического очага, и определение возрастных и половых различий у данной категории пациентов. Материал и методы: в комплексном исследовании приняли участие 229 пациентов с ЦА 1-3 стадии и СД2. Пациенты были разделены на 4 группы: 1-я группа — перенесшие ишемический инсульт (ИИ) в правом полушарии (ПП), 2-ая группа — перенесшие ИИ в левом полушарии (ЛП), 3-я группа — с ЦА 1-2 стадии (без ИИ — группа сравнения) и 4-я группа — общая группа пациентов, перенесших ИИ. Дизайн — исследование простое, проспективное, нерандомизированное, с последовательным включением пациентов. Результаты и обсуждение: Сравниваемые между собой группы статистически значимо различались по индексу ЛП, индексу конечно-диастолического размера, индексу конечно-систолического размера и толщине стенок левого желудочка (ЛЖ). Межполушарные отличия были зарегистрированы только в отношении величины ударного индекса. Эксцентрическая дилатационная гипертрофия ЛЖ (ГЛЖ) наблюдалась у пациентов с ИИ в 2,2 раза чаще, чем у пациентов с ЦА, а концентрическая дилатационная ГЛЖ встречалась у пациентов с ЦА 1-2 стадии в 1,8 раз чаще, чем у пациентов с ИИ. Межполушарные отличия наблюдались только в отношении III и V типов ГЛЖ. Для пациентов с ЦА 1-2 стадии и СД2 не установлены возрастные и половые различия в показателях структурно-функционального состояния сердца. Для пациентов с СД2, перенесших ИИ, характерны следующие возрастные и половые различия: статистически значимые большие размеры полости ЛЖ, ударногообъема (УО), минутного объема кровотока (МОК) и общего периферического сопротивления сосудов (ОПСС) присущи мужчинам, а статистически значимые меньшие размеры полости ЛЖ и большая толщина стенок ЛЖ наблюдаются после 60 лет. Выводы: у пациентов с ЦА 1-3 стадии наблюдаются статистически значимые отличия морфо-функциональных изменений сердца, интракардиальной и системной гемодинамики и геометрии ЛЖ, причем некоторые из этих отличий носят «полушарный» характер, а возрастные и половые различия характерны только для пациентов с ИИ и СД2.
The Development of Telecommunication Networks in Angola Republic
Authors: Nzinga T. , Koucheryavy A.
Published: February 2021

Research subject. The article is devoted to the analysis of the development of telecommunication net-works in the Republic of Angola and the prospects for their development Method. System analysis. Core results. Determination of promising areas of research in the development of communication net-works in terms of their creation in sparsely populated and hard-to-reach areas. Practical relevance. The results of the article can be used to modernize the telecommunication network

of the Republic of Angola.
Exploring a Model Network for Orchestation IoT Services Based on Kubernetes
Authors: Ermolenko D. , Kilicheva K , Khakimov A. , Muthanna A.
Published: February 2021

This paper focuses on the implementation of the concept of microservices, which can be used to design and implement distributed edge services for IoT applications. Basically, IoT is a platform where integrat-ed services are connected to a common network, so all devices are able to collect and exchange data with each other. Typically, monolithic user mobility services are developed for the core components of the ETSI MEC Unified Systems Reference Architecture. The ETSI MEC views microservices as a tool for separating monolithic applications into a set of loosely coupled distributed components, i.e. which provides an independent unit that implements a function. This architecture is expected to facilitate dynamic adaptation at runtime. However, increased modularity can also increase the load on orchestration and system management. In MEC, user equipment is connected through gate-ways to microservices running at the edge node. In the work, a distributed service is implemented using Docker containers and is designed to actually adapt to surrounding low-capacity servers. The results demonstrate that low latency for edge applications can be achieved with this kind of implementation. The integration of software technology with a standardized boundary system provides a solid foundation for subsequent development. This article discusses the use of edge computing architecture and Kubernetes for orchestration and management of network applications.
PSYCHOLOGICAL CHARACTERISTICS OF LEADING THE JUNIOR FOOTBALLERS’ TEACHING - LEARNING PROCESS
Authors: BARBU D. , FORŢAN C. , STOICA D.
Published: February 2021

The coach is directly responsible for the good accomplishment of the process of transmitting the information, but especially for his result – preparing today's athletes to become members with full rights, but also with responsibilities in tomorrow's society. The paper highlights the priority aspects of the psychological peculiarities of the junior footballers’ personality and their importance in gaining performance. The conclusions of the current research will make the coaches’ teaching process as well as the athletes’ learning more efficient.
THE ASSESSMENT OF WORK CAPACITY IN UNTRAINED ADULTS
Authors: CRISTUȚĂ M.A. , LUPU G.S.
Published: February 2021

Currently, the concept of health involves not only a psychological and physical well being of the individual and community, but also a certain ability for physical effort, and regaining your strength after effort, of resistance against the unfavorable environmental factors, against diseases, and a certain longevity, in concordance with the socio-economic and geographical conditions in which a person performs his/her activity. Thus, a person cannot be considered healthy if they do not have a good work capacity and/or a certain nonspecific general resistance to the unfavorable environmental factors and to diseases. This study aimed to assess the work capacity in a group of untrained subjects.
ATTITUDES AND BEHAVIORAL PICTURE OF STUDENTS REGARDING ASPECTS OF PHYSICAL WELL-BEING
Authors: POPA M. , STOICA D.M.
Published: February 2021

The research is a synthesis of a survey based on the FRESH questionnaire - physical activity and lifestyle, adapted and translated, applied to students of the Faculty of Engineering Hunedoara. Out of the total of 50 Items of the questionnaire, only those referring to the following indicators were processed: health status, level of physical activity, information on nutrition, lifestyle data and opinions on physical activity. The interpretation of the data with the help of the graphical method and the statistical method, using the program SPSS and Excel, allowed the creation of a relevant image of the studied phenomena and of the relations between them
THE IMPACT OF THE BETTING INDUSTRY ON SPORTS
Authors: TURCU I. , BURCEA G.B. , DIACONESCU D.L.
Published: February 2021

Sports betting is the oldest form of gambling in the world. In the beginning, it was simply a leisure activity. We are currently talking about a multi-billion-euro deal. The sports betting industry has changed more in 15 years than in the last 50 years. In the 1950s, sports betting began to enter the world and almost nothing changed until the beginning of the 21st century. However, with the onset of the new millennium, online betting has changed the landscape dramatically, and is now developing at a fast pace than ever before. The future is always unpredictable, but we will try to imagine it based on current trends in sports betting. The paper "The impact of the betting industry on sports" aims to present a series of aspects regarding the history of sports games, the types of sports games existing today, a brief highlight of the Romanian sports games market and a short presentation of the positive and negative effects on sports.
Considerações filosóficas sobre as entrevistas de solicitação de refúgio
Authors: Gurgel Diogo , Maciel Corrêa Andressa
Published: February 2021

No presente artigo, procuramos mostrar que o processo de solicitação de refúgio pode ter suas estruturas semânticas e políticas evidenciadas a partir de um acesso via filosofia da linguagem. Visando elucidar a natureza normativa dessa prática social e assumir uma postura crítica com relação ao tratamento dado à entrevista de refúgio conforme ela vem sendo feita no país, recorremos a certos conceitos elaborados por Wittgenstein em sua fase madura (como, por exemplo, os conceitos de regra e jogo de linguagem). De modo a conferir um tratamento mais completo ao objeto de estudo, acionamos também de autores do Círculo de Bakhtin, os quais exploram dimensões comunicacionais que o filósofo vienense não explorou propriamente – com especial ênfase nos “acentos de valor”. Visando coligir evidências empíricas relevantes para os nossos fins, foi realizada uma pesquisa de campo com profissionais e voluntários envolvidos nas entrevistas de solicitação de refúgio. Os relatos daí oriundos forneceram-nos mais bases para as considerações que fazemos acerca da fragilidade normativa do jogo de linguagem da entrevista e do intrincado sistema de valores que orienta a interação entre entrevistador (Oficial de Elegibilidade), intérprete e entrevistado (solicitante de refúgio).
Dignidade humana em Adam Smith: a conciliação entre liberalismo e moral
Authors: Costa Thais Alves , Barbosa Evandro
Published: February 2021

A visão mainstream do século XX sugere que o filósofo e economista escocês Adam Smith fez uma defesa de teoria liberal pautada exclusivamente no individualismo tout court e no puro cálculo racional da economia. Sob essa ótica, liberalismo e ética sentimentalista seriam elementos totalmente dissociados e independentes no pensamento smithiano. Entretanto, consideramos que esta é uma interpretação enviesada que desconsidera a leitura conjunta de suas obras centrais The theory of Moral Sentiments (1759) e Wealth of Nations (1776), o que inviabiliza uma compreensão global do seu pensamento. Contra essa visão dominante, propomos, como objetivo central do presente artigo, a conciliação entre liberalismo clássico smithiano e sua ética sentimentalista, a partir da noção de dignidade humana presente no reconhecimento do outro como um igual. Se esta hipótese estiver correta, defenderemos a tese de um liberalismo simpático no sistema filosófico de Adam Smith. Para isso, inicialmente, analisaremos o sentimento de simpatia smithiano e sua interferência nas relações interpessoais e, em seguida, o dispositivo de justificação moral da imparcialidade enquanto promotora de comportamentos justos. Por fim, sustentaremos que o entrelaçamento desses dois elementos da ética sentimentalista smithiana, no espaço público, engendra uma noção de dignidade humana compatível com o seu liberalismo, na medida em que respeita as liberdades individuais ao mesmo tempo em que propicia o progresso das sociedades comerciais. Para isso, utilizaremos como fios condutores dessa pesquisa, a obra de Adam Smith Theory of Moral Sentiments e a análise interpretativa do filósofo norte-americano Stephen Darwall no artigo Sympathetic Liberalism: Recent Work on Adam Smith .
O liberalismo como base para um sistema político, social e econômico na pós-história de Hegel e Fukuyama: um contraponto à luz de Hans Jonas
Authors: Cescon Everaldo , Frizzo Fábio André
Published: February 2021

O objetivo deste artigo é reforçar o alerta que o filósofo alemão Hans Jonas faz em sua obra Princípio responsabilidade sobre a iminente possibilidade de um final de história trágico para a humanidade se forem considerados os efeitos imprevisíveis decorrentes da forma de atuação do sistema político-econômico liberal e do inconsequente avanço da tecnologia que dele decorre. Nesse intento, optou-se como estratégia, enfraquecer e rebater a ideia hegeliana, oposta à visão de Jonas, de que não haveria motivos para alarmes porque a história, no seu desenvolvimento, é orientada por uma razão imanente e bem intencionada que conduz inevitavelmente a humanidade ao reino da liberdade e ao espírito absoluto. Mais recentemente, o filósofo, economista e cientista político americano Francis Fukuyama, apoiando-se em Hegel, decretou que a história havia chegado ao seu fim com o ápice da evolução sociocultural da humanidade. Nesse contexto, busca-se, inicialmente, apresentar uma análise interpretativa das ideias de Hegel e Fukuyama para, a seguir, realizar-se uma crítica a essa forma de pensar, à luz dos argumentos de Hans Jonas. Por fim, conclui-se, pelas lentes jonasianas, que a história, além de não ter chegado ao seu fim, como Fukuyama afirmou, pode também ter um final bem distinto daquele imaginado por Hegel. Portanto, não se deve desconsiderar a ocorrência da hipótese de uma morte essencial seguida de uma morte física do gênero humano, bem antes que o projeto hegeliano da liberdade tenha chance de se realizar. Na dúvida, é melhor que o homem desconfie da existência e(ou) da intenção e(ou) da capacidade de uma razão imanente e reassuma a tempo as rédeas de seu próprio destino, por meio da adoção de um novo princípio ético: o da responsabilidade.
Pensar em modelos: Adorno e a filosofia como exercício
Authors: Correia Fábio Caires
Published: February 2021

A Dialética negativa é uma das mais importantes obras do pensamento de Theodor W. Adorno, não apenas devido ao fato de que ali ele expõe os pressupostos epistemológicos fundamentais para a compreensão de sua constelação – método de análise e procedimentos –, mas também porque nela a ideia de experiência filosófica é, efetivamente, exercício do pensamento. A proposta do presente texto é tratar a figura-chave pensar em modelos, a partir de outro modelo de pensamento, leia-se, a intricada relação teoria e prática.