bluuebunny/crossref_metadata_2025 huggingface dataset:
Survey of clinicians on the use of adjuvant therapy for premenopausal women with breast cancer
Authors: Lee Young-Won , Ahn Sei-Hyun , Lee Young-jin , Yoo Tae-Kyung , Kim Jisun , Chung Il Yong , Kim Hee Jeong , Ko Beom Seok , Lee Jong Won , Son Byung Ho , Lee Sae Byul
Published: August 2023

Purpose

Considering prognostic and anatomic stages in early-stage premenopausal patients with breast cancer, clinicians decide on performing the multigene assay, adjuvant chemotherapy, or ovarian function suppression (OFS). This decision is also based on genetic information related to hormone receptor-positive and human epidermal growth factor receptor 2 negative results. We aimed to determine the tendency to use adjuvant therapy in clinical practice.

Methods

From April to May 2022, clinicians of the Korean Breast Cancer Society responded to a web-based survey. The survey included 62 multiple-choice questions mainly on decision-making under different pathologic conditions.

Results

Among 92 responding clinicians, 91.3% were breast surgeons. For 35-year-old patients (pT2N0 and Ki-67 50% profile), 96.8% of clinicians selected chemotherapy, whereas 50.7% selected chemotherapy for patients with pT1N0, Ki-67 10%, and without Oncotype Dx (ODX). Only 35.6% selected chemotherapy for 47-year-old patients with the same profiles, while 84.3% and 49.1% chose chemotherapy with ODX recurrence score 21 and 16, respectively. More clinicians selected tamoxifen (TMX) plus OFS than aromatase inhibitor (AI) plus OFS for 5 years of endocrine therapy in patients with adjuvant chemotherapy regardless of genomic and clinical risks. However, for the same patients without adjuvant chemotherapy, more clinicians selected AI plus OFS. A longer duration of additional OFS and TMX was selected in patients with high clinical and genomic risks, and the duration of OFS was relatively shorter in older patients.

Conclusion

The decision regarding adjuvant therapy should be made considering clinical and genomic risks and age, and clinicians should consult with patients about adverse effects and compliance.
The impact of COVID-19 on maternal death and fetal death, a cohort study in Brazil
Authors: Brioschi dos Santos Ana Paula , Vicente Creuza Rachel , Cola João Paulo , Tanaka Luana Fiengo , Garbin Juliana Rodrigues Tovar , Dell’Antonio Larissa Soares , Dell’Antonio Cristiano Soares da Silva , Miranda Angelica Espinosa
Published: August 2023

Objective

The study aimed to evaluate the risk of maternal death and fetal death among pregnant women infected with SARS-CoV-2.

Methods

This is a retrospective cohort study among pregnant women with secondary data from the National Live Births System (Sistema Nacional de Nascidos Vivos), National Mortality System (Sistema Nacional de Mortalidade), and e-SUS Health Surveillance System (Sistema e-SUS Vigilância em Saúde). Pregnant women confirmed for COVID-19 had positive RT-PCR between March 2020 and May 2021, pregnant women without COVID-19 were those without notification for disease. Maternal death, fetal death, and stillbirth were assessed as primary outcomes.

Results

We included 68,673 pregnant women not notified as suspected of COVID-19 and 1,386 with a confirmed diagnosis of COVID-19. Among pregnant women with COVID-19, 1013 (73.0%) were aged 20 to 34 years, 655 (47.2%) were brown, 907 (65.4%) had ≥ 8 years of education, in the third trimester of pregnancy (41.5%), undergoing cesarean section (64.5%). In adjusted analyses, COVID-19 in pregnancy had a higher risk of maternal death (relative risk [RR] 18.73–95% confidence interval [95%CI] 11.07–31.69), fetal death/stillbirth (RR 1.96–95%CI 1.18–3.25), preterm birth [RR 1.18–95%CI 1.01–1.39], cesarean delivery (RR 1.07–95%CI 1.02–1.11), and cesarean delivery occurring before the onset of labor (RR 1.33–95%CI 1.23–1.44).

Conclusion

COVID-19 may contribute to unfavorable pregnancy outcomes. Results showed that pregnant women infected with SARS-CoV-2 had a higher risk of maternal death, fetal death/stillbirth, preterm birth, cesarean delivery, and cesarean section occurring before the onset of labor.
Whose eggs are these? Gender in ocean-themed picture books
Authors: Venzo Paul , Hedberg Lara , Francis Prue
Published: August 2023

Ocean-themed picture books are important educational resources that promote marine science literacy. At the same time, these picture books also carry messages about gender to child readers. Through an analysis of 100 ocean-themed informational and narrative non-fiction picture books, the authors uncover various ways in which ideas about gender are communicated to child readers, whether in relation to human or animal characters or animals with human traits and qualities. The article tests the hypothesis that marine science picture books educate children about gender in traditional, normative and binarized ways. The findings suggest that marine science picture books are male-dominated, with narrow, often stereotyped gender roles ascribed to both human and sea animal characters. Despite a male-dominated presence, the authors describe ways in which contemporary picture books might begin to fill the gaps in diverse gender representation in this genre.
Análise ergonômica no processo de recuperação de racks em uma indústria do polo de duas rodas em Manaus – Amazonas
Authors: Ferreira Pedro Henrique da Silva , Justa Marcelo Augusto Oliveira da , Silva Ronilson Oliveira da
Published: August 2023

O artigo apresenta um estudo de caso com a Análise Ergonômica do Trabalho (AET) numa indústria de duas rodas localizada no polo industrial de Manaus, no processo de recuperação de racks da empresa. Buscou-se identificar pontos críticos para a realização do trabalho e propor melhorias no sentindo de evitar potenciais problemas ergonômicos nos colaboradores da empresa. Foram avaliadas as formas de trabalho, identificados os problemas e melhorias na execução das atividades dos colaboradores. A metodologia se caracteriza por ser exploratória e explicativa, com abordagem mista e acompanhada de uma análise ergonômica do trabalho. Na obtenção dos dados, observou-se os colaboradores que desenvolvem as atividades dos postos de trabalho no processo de recuperação de racks. Com a análise dos dados coletados, identificou-se as formas de manipulação de materiais e dados ambientais inadequados. A partir da análise realizada, recomenda-se mudanças ergonômicas para gerar transformações significativas no setor estudado, visando um melhor conforto ao operador e adequação as normas ergonômicas no posto de trabalho. Por meio das melhorias implantadas, foram obtidos resultados positivos em relação aos aspectos referentes a saúde e segurança dos colaboradores, com a expectativa da diminuição de doenças, afastamentos, aumento do bem-estar e conforto, bem como à melhoria de produtividade.
Corporate Governance Enhances the Performance of Financial Institutions: A Comparative Study on Banking Industry of Bangladesh
Authors: Datta Rajib , Barua Sujoy , Mawa Jannatul
Published: August 2023

Corporate Governance refers to the manner by which organizations are administered and to what reason. It distinguishes who has power and responsibility, and who simply decides. Corporate Governance has become visible noticeably over the world particularly in business regions like banks, NBFIs, insurances, administrative bodies, and autonomous bodies. This study intends to critically notice the exhibition of financial institutions improved by ensuring great corporate governance and what are the deterrents holding behind to accomplish it. From this examination we can gather that, various sorts of financial scams and advance defaulting hampering the business enormous. We had compared information gathered from 20 banks including both conventional and Islamic bank contrasting year 2020 with year 2022 recorded and controlled under Bangladesh Bank's administration. The corporate governance practices in Bangladesh have been largely limited to financial Sector and the Banking sector can serve as a motivation for better corporate governance through its requirements and procedures for approving and monitoring loans. These results suggest that better corporate governance mechanisms are imperative for every banking company and should be encouraged for the interest of the investors and other stakeholders as well as company’s both financial & operational activities.
Novel Oral CGRP Receptor Antagonist Atogepant in the Prevention of Migraine
Authors:   Clemson University, Clemson, SC 29634, USA, Chowdhury Selia , Dave Tirth ,   Bukovinian State Medical University, Chernivtsi, Ukraine
Published: August 2023

Advancements in molecular biology and neuroscience have uncovered calcitonin gene-related peptide (CGRP), a neuropeptide consisting of thirty-seven amino acids that plays a crucial role in migraine pathogenesis. CGRP receptor antagonist or gepant is an oral medication that can impede the nociceptive signaling pathway related to CGRP. Atogepant, the latest CGRP antagonist approved by the Food and Drug Administration (FDA) for prophylaxis of episodic migraine, works by non-competitively blocking CGRP receptors, thereby curtailing neurogenic inflammation and pain sensitization. Numerous trials have demonstrated that atogepant is an effective therapy for migraine prevention, with its extended half-life and minimal risks of cardiovascular or liver toxicity making it the first drug in its class primarily authorized for that purpose. In terms of monthly migraine days, monthly headache days, and acute medication usage days, atogepant demonstrated a statistically significant difference from baseline. It was well-tolerated with low adverse event rates. The most commonly reported adverse events were constipation and nausea. Atogepant appears to be beneficial for migraine prevention, and it may be more useful in those who do not want to take the medication as an injection or who do not require a lengthy duration of pharmacological impact. In this article, we provide a systematic review of the literature on atogepant and migraine, emphasizing current achievements in this field of study.
Very High Cycle Fatigue and Ultrasonic Testing in Multiaxial Loading
Authors: Costa Pedro R. , Reis Luís , Freitas Manuel
Published: August 2023

Fatigue damage has special relevance on the lifespan of mechanical components and structures, as it takes responsibility for the majority of registered structural failures. Most fatigue testing today still uses uniaxial loads, nonetheless it is generally recognized that multiaxial stresses occur in many full-scale structures. Nowadays, the growing need for greater lifespans forced the study of material behavior under what is nowadays very high cycle fatigue (VHCF) regime, fatigue research beyond 10E07 up to 10E10 cycles. However, most classic fatigue machines are often very costly, both in terms of time and energy, for such an elevated number of cycles. The high costs of equipment and time to conduct such experiments have seen a massive improvement with the introduction of high frequency ultrasonic machines. Presently, it is already possible to characterize materials VHCF response under axial and multiaxial loading conditions in a fraction of the time. Ultrasonic testing machines were first introduced for simpler uniaxial loading and more recently adapted for multiaxial loading conditions. The present work reviews the current background of ultrasonic fatigue testing machines working at 20-kHz frequency, with emphasis on multiaxial fatigue and VHCF. A review of a series of fatigue tests are presented, respectively, axial, shear, axial/shear, and in-plane bi-axial fatigue tests with different combining dimension specimens allowing different shear/axial stress ratios. Special attention will be put into the performance of multiaxial classical cylindrical specimens under tension/torsion and flat cruciform specimens under in-plane bi-axial testing using low-cost piezoelectric transducers. By comparing all so far developed and successfully reached multiaxial specimens and respective methodologies, two base approaches were possible to be established. When designing new specimens or ultrasonic machines, or both, one of the two methods must be followed. To have a well-comprehended methodology and successful design approach will undoubtedly guide future multiaxial ultrasonic method ideas.
Non-deep physiological dormancy in seeds of two endangered medicinal alpine species of Rhodiola from the Hengduan Mountains of southwest China
Authors: Peng Deli , Geng Boyang , Qin Yingbo , Yang Li-E , Baskin Jerry M. , Baskin Carol C.
Published: August 2023

We investigated seed dormancy and germination characteristics of two endangered medicinal species, Rhodiola crenulata and R. fastigiata, from the high altitude (alpine) Hengduan Mountains in China. Germination of fresh seeds was tested in light and dark at six constant
(1, 5, 10, 15, 20 and 25°C) and three alternating (5/1, 15/5 and 25/15°C) temperatures and again, after six months of dry after-ripening (DAR) and cold-wet stratification (CS). Fresh seeds of R. crenulata germinated to ≥ 80% at 10, 15, 25/15 and 15/5°C in light, but germination
was significantly lower at 1, 5, 20 and 25°C. Germination of fresh seeds in dark was 0 to 25% across the range of temperatures. DAR and CS for six months increased germination and/or decreased mean germination time in both light and dark. Fresh seeds of R. fastigiata germinated
to > 95% in both light and dark, except at 1°C in light and 1, 5, and 5/1°C in dark, where germination was < 50%. DAR and CS for six months increased germination and/or decreased mean germination time. Seeds of the two Rhodiola species have (conditional) non- deep physiological
dormancy. Germination responses to temperature and light prevent seeds from germinating in the autumn of dispersal, but allow them to germinate quickly after snow melt the next spring. This study provides a method for obtaining plants from seeds of the two Rhodiola species for medicinal
uses, which could reduce the harvesting pressure placed on natural populations.
Special features in the formation of professional competence of students with “Pedagogical education (foreign languages)” as a major subject
Authors: Danko Yury
Published: August 2023

Higher education, being primarily professional education, aims to train a specialist with the necessary qualifications aimed at solving professional problems in a particular sector of the economy, and is also focused on the formation of a harmoniously developed personality. In this regard, pedagogical education, also focused on the training of a teacher of a certain qualification, puts the foundation of professional knowledge and practical pedagogical skills as pedagogical and methodological competencies as the basis of training, and for a teacher of a foreign language, the subject competence is the formation of a foreign language communicative competence of a certain level. This article describes the theoretical features of the formation of professional competence of a teacher in undergraduate studies as a basic level of professional education based on theoretical and methodological provisions and functional components of education; also, on the basis of an experimental study, the formed communicative and methodological levels of readiness of future teachers of a foreign language were determined, as a result of which a lack of methodological knowledge of future teachers in terms of the practical organization of the teacher's work was established. One can also note the absence in the education standards of specific requirements necessary for professional activity. In particular, for a foreign language teacher, the specific knowledge, skills and abilities required for further work are not indicated.
Opportunities for the formation of traditional family consciousness among university students
Authors: Morozova Elena
Published: August 2023

The present study is the result of empirical studies devoted to the study of the possibilities of forming components of traditional family consciousness among university students. The relevance of the work is due to the destabilization of the institution of the family with the emergence of demographic problems, which encourages the search for ways to revive the family lifestyle, which is based on traditional family consciousness, which contributes to the solution of life-meaning problems related to the acquisition of identity in intersex and marital-family relations, and is the basis for the creation of a traditional family, which is the most important way to prevent demographic problems and anthropogeny. The paper presents the author's approach in understanding the traditional family consciousness, the possibilities of its study and formation in an educational environment. A diagnostic algorithm has been developed that includes a set of techniques that allow identifying the initial level of the components of family consciousness (attitude-cognitive, value-semantic, activity-behavioral) and its individual components (ideas about family, expectations from family, emotional stereotypes associated with family, family meanings, family values, family image, attitudes, behavioral practices related to family, etc.). The results of a formative experiment conducted among university students, including the implementation of family-oriented programs developed by the author of the work ("Orthodox family studies" for students of SAMDS, as well as "Development of family consciousness of personality" for students of universities of SamGUPS), are presented. The results obtained, processed using methods of mathematical statistics and modeling, allowed us to conclude that there is a positive dynamics among some students in the context of the formation of components of family consciousness within the framework of the traditional model based on essential fundamentals, which encourages further work in this direction.
Lesiones iatrogénicas del nervio radial en la osteosíntesis de la diáfisis humeral
Authors: López Bustos Francisco , Fernández Alexis , Martínez Carlos Eugenio
Published: August 2023

Introducción: Los objetivos de este estudio fueron determinar la incidencia de lesión iatrogénica intraquirúrgica del nervio radial durante la osteosíntesis de la diáfisis y el extremo distal del húmero, distinguir factores de riesgos asociados y reconocer elementos pronósticos que participan de su recuperación.
Materiales y Métodos: Se evaluó, en forma retrospectiva, a 82 pacientes con osteosíntesis de húmero entre 2005 y 2021, sin parálisis radial preoperatoria. Se consideraron los sistemas de fijación utilizados, y se compararon las cirugías primarias con las reoperaciones y el tiempo transcurrido entre estas. El diagnóstico de parálisis radial posoperatorio fue clínico. Todos los pacientes fueron tratados con férula en extensión de muñeca, electroestimulación, kinesiología y vitaminas B1, B6, B12. La electromiografía se solicitó a los fines del pronóstico.
Resultados: Nueve pacientes tuvieron déficit motor del nervio radial en el posoperatorio inmediato. El sistema de fijación era una placa (7 casos), sistema de cable-placa (1 caso) y clavo endomedular acerrojado anterógrado (1 caso). Siete ocurrieron en cirugías primarias y dos en reoperaciones. El 88% recuperó su función motora completamente antes de los 6 meses después de la parálisis. La electromiografía reveló unnervio radial no excitable en el 22% restante con parálisis definitiva.
Conclusiones: El uso de placa de osteosíntesis, la disección intraoperatoria del nervio radial y las reoperaciones aumentan la incidencia de parálisis. Un nervio radial no excitable se relaciona con un peor pronóstico de recuperación espontánea.
Alegorias da fé
Authors: Nascimento Robéria Nádia Araújo
Published: August 2023

Na trilha epistemológica dos Estudos Culturais (HALL, 2004, 2016) uma ficção do gênero terror torna-se eixo para compreensão e análise da concepção de intolerância religiosa. Trata-se da minissérie americana Missa da Meia-Noite (Midnight Mass) cujas condições de representação, apropriação, intencionalidades e disputas simbólicas aproximam o imaginário popular e os arquétipos religiosos permitindo reflexões sobre preconceitos, estigmas e tensionamentos que afetam as crenças minoritárias no nosso país, especialmente as de matrizes africanas. A partir dessa problematização, o raciocínio empreendido busca corroborar o extraordinário poder que as histórias “inventadas” para a TV adquirem na construção de verossimilhança como fontes imersivas de intertextualidades, pluralidade de vozes e produção de sentidos (BULHÕES, 2009).
Disseminated cysticercosis in humans
Authors: Celi Simbaña Stalin Santiago , Andrade Mora Diego Sebastián
Published: August 2023

Human cysticercosis, caused by the parasitic infection of Taenia Solium, is an important challenge for public health in Ecuador and other countries where poor sanitary conditions are a key factor for its appearance. In this series of cases, we publish the imaging findings corresponding to three patients treated in 2022 at the Center of Medical Specialties “Comité del Pueblo” Quito - Ecuador, in which, through radiographic images, multiple radiodense lesions were found in different anatomical regions which follow the typical pattern of distribution parallel to the muscular tissues of the affected region, generating the radiological sign known as “rice grain calcifications”, which corresponds to the presence of Disseminated Cysticercosis (DCC)in the muscular tissue of the host.
Aplicación de ejercicios especiales para mejorar la ofensiva en el béisbol categoría 9-10 años del municipio bayamo. Consideraciones teoricas
Authors: Bárzaga Rodríguez Alfredo Michel , Peña Santisteban Anisley , Blanco Fajardo Alberto
Published: August 2023

La investigación se realizó con 10 atletas del equipo de béisbol representativo del municipio Bayamo, los mismos presentan deficiencias en el dominio de los elementos básicos ofensivos, esta se realizó en los terrenos del estadio de mini béisbol “Mario Alarcón Reina”, perteneciente a la Escuela Comunitaria “Jesús Menéndez” del municipio Bayamo, Provincia Granma. Se trabaja con una población, conformada por 10 niños de 3er y 4to grado, cuyas edades oscilan entre 9 y 10 años del sexo masculino, se contó además con el apoyo de 3 profesores Licenciados en Cultura Física y las 10 familias encargadas de atender a estos infantes. Los métodos utilizados fueron, dentro de los teóricos: el análisis y la síntesis, el inductivo deductivo, el histórico- lógico, la revisión de documentos oficiales, como empíricos se aplicaron: la observación, la medición y como técnicas se emplearon la entrevista, la encuesta, el experimento y el procesamiento estadístico SPSS. para Windows. El objetivo fundamental está orientado en: Aplicar un conjunto de ejercicios especiales, para lograr un mejoramiento de los elementos básicos ofensivos en estos atletas que presentan poco dominio de dicha técnica, encaminado a mejorar sus resultados deportivos, así como contribuir a una formación general e integral como futuros atletas.
Comparison between optical and electrophysical data on hole concentration in zinc doped p-GaAs
Authors: Belov A. G. , Kanevskii V. E. , Kladova E. I. , Knyazev S. N. , Komarovskiy N. Yu. , Parfent’eva I. B. , Chernyshova E. V.
Published: August 2023

Optical and electrophysical properties of Cz-grown zinc doped p-GaAs samples have been investigated. Middle-infrared reflection spectra of ten p-GaAs samples have been obtained. Galvanomagnetic Van der Pau measurements have been made on these samples also, and the values of resistivity and Hall coefficient have been calculated. All experiments have been carried out at room temperature.Reflection spectra have been processed by Kramers–Kronig relations. The spectral dependences of real and imaginary parts of complex dielectric permittivity have been obtained and loss function has been calculated. The value of characteristic wave number corresponding to high-frequency plasmon-phonon mode has been determined by loss function maximum position.The theoretical calculations have been made, and the dependence has been obtained which gave the possibility to determine heavy hole concentration value at T = 295K by the value of characteristic wave number. Then by comparison of optical and Hall data the values of light hole mobility to heavy hole mobility ratio have been determined. This mobility ratio has been shown to be equal to (1.9–2.8) which is considerably less, than predicted theoretical value based on assumption that both light and heavy holes are scattered by optical phonons. It has been suggested that scattering mechanisms of light and heavy holes might be quite different.
AN INVESTIGATION ON MARONITES’ HOUSES IN KONYA
Authors: ERDOĞAN H. Abdullah , ERDOĞAN Ebru
Published: August 2023

Aim: There were many minority subjects under the rule of the Ottoman Empire. These minorities that are active especially in trade and social life, have been able to find the environment in which they will live their own culture. The Maronites, which are among these groups, migrated to the inner parts of Anatolia, including Cyprus, Mersin and Konya, in 1860 due to the internal conflicts in Lebanon. While blending in the local culture, they have been an important element of commercial and social life in Konya with their own identity and culture. This study aims to show how some of the Maronites, who had to migrate to various parts of the Ottoman Empire and settle in Konya, shaped and expressed their houses differently from the local architecture while living in the same climate, topography and geography, and to show how the different beliefs and culture, manifested themselves in their architecture. Method: Within the scope of the study, civil architecture examples built by the Maronites starting from the end of the 18th century in the city centre of Konya were determined from the inventory studies and the Cultural Heritage Preservation Board records. Literature researches were conducted on the subject. Samples that have preserved their characteristics today and are still standing in city centre were selected and examined. Results: The current status of the houses which belonged to Maronites, located on the line between the Anıt Square and historical Girls’ Teachers School in Konya city centre were determined and the Chamber of Architects building, Ataturk Museum, Arapoğlu Kosti House and the Girls’ Secondary School were selected as they reflect the architectural identity of the Maronites. The common features of these houses were determined and compared with traditional Konya houses. Thus, it was observed how these effects were reflected in the houses shaped by different socio-cultural influences, both in terms of spatial organizations and in terms of facade characteristics. Conclusion: Considering the common features of the selected Maronite houses in the study area, although there are similarities with traditional Konya houses in terms of the plan, it is seen that there are baroque and orientalist influences in the plan and the facade in terms of materials used, also in the entrance opening the street, the construction of the façade (such as cornerstones, floor mouldings and window jambs), and the onion dome or wavy eaves detailed roof cover, unlike the traditional civil architecture.
Latin American Perspectives on Parenthood and Disability: Vulnerability, Risk, and Social Inclusion
Authors: Sanmiquel-Molinero Laura , Pujol-Tarrés Joan , Montenegro Marisela
Published: August 2023

Despite the growing recognition and acceptance of disabled people’s sexuality, there are barriers to parenthood anchored in metaphors of vulnerability and risk. The social inclusion of disabled parents seems both desirable and risky, making disabled parenthood one of the current frontiers of inclusion for the disabled body. The interest in disabled parenting in Anglo-Saxon academic literature has barely been considered related to Latin American production. This article aims to address this gap by exploring the Latin American scientific community’s understanding of parenthood and disability. To do so, we conduct a pragmatic discourse analysis of Latin American scientific articles in Web of Science (in English) and RedALyC and SciELO (in Spanish). Our findings show how the Latin American scientific community draws on different models of disability—in some cases introducing an intersectional perspective—that reproduce metaphors of vulnerability/risk regarding parenthood. We conclude by highlighting the importance of establishing dialogues between critical perspectives on disability from the Anglo-Saxon and Latin American contexts to address the complexities of the reproduction processes of disabled people. These dialogues can contribute to problematising the metaphor of vulnerability/risk currently associated with disabled parenthood.
Free time of citizens as an intangible benefit in need of civil protection posing the problem
Authors: Malinova A. G.
Published: August 2023

Analysis of common forms of violations of the information security of citizens shows that in modern conditions not only the advertising information itself is a commodity, but also the free time of citizens spent by them on viewing and listening to it consistently turns into a commodity. Behind these phenomena, which have not yet received a proper legal assessment, lie real threats that are emerging in various areas of public life. Based on the traditional views of russian public thought on the relationship between the law and human well-being, which have centuries-old historical roots, it is suggested that, based on considerations of economic justice and, since the free time of citizens, their mental and activity potentials and communication devices belonging to them have value, there is a need for a doctrinal discussion of the possibilities of creating compensatory mechanisms for compensation. time that citizens are forced to spend on viewing and listening to advertising texts, videos, clips, etc. imposed on them, but also the lost time in other cases of violation of the information security of citizens. Such a formulation of the question is not only appropriate, but also seems to help determine the potential for normative support for the realization of this kind of economic justice.
Role of macrophage derived small extracellular vesicles (sEVs) in regulation of T cell mediated resolution of inflammatory pain
Authors:   , Pande Richa , Ajit Seena
Published: August 2023

Chronic pain is the most prevalent, disabling, and expensive public health condition in the United States. Aberrant neuroimmune signaling underlies the development of chronic pain. Small extracellular vesicles (sEVs) play an important role in intercellular communication and are critically involved in mediating immune modulatory effects. Currently, very little is known about signaling mechanisms by which sEVs modulate inflammatory pain. We observed that sEVs from RAW 264.7 macrophage cells show therapeutic efficacy in a complete Freud adjuvant (CFA) mouse model of inflammatory pain in both male and female C57BL/6j mice. sEVs from antigen presenting cells (APCs) such as macrophages express major histocompatibility complex (MHC) and costimulatory molecules and thereby activate T cells. As T cells have been shown to be important for pain resolution, we hypothesized that macrophage-derived sEVs promote resolution of inflammatory pain hypersensitivity by modulating host T cell responses. While sEVs were unable to directly activate isolated T cells in vitro, sEV treatment of total splenocytes induced the activation of APCs and T cells. Intrathecal administration of sEVs in the CFA model showed lower frequencies of pro-inflammatory T helper 1 cells and increased immunosuppressive regulatory T cells. sEV treatment also enhanced TGF-[beta]1 production. Smad7 binds to TGF-[beta]1 receptor and inhibits TGF-[beta]1 driven Smad signaling. Our in vitro studies showed that miR-21 transfer by sEVs inhibited Smad7 mRNA in recipient T cells. We also observed that sEVs released by RAW 264.7 derived sEVs harbor both activated and latent TGF-[beta]1 on their surface. To evaluate if T cells were required for the sEV mediated resolution of inflammatory pain, we performed adoptive transfer of T cells into RAG2-/- mice. We observed that administration of sEVs increased the pro-resolution effects of T cells and that T cells were both necessary and sufficient for sEV mediated resolution of inflammatory pain. sEVs may represent a novel strategy to promote the endogenous pain resolving role of T cells in vivo without the cost and technical challenges associated with personalizing T cell therapies. Our studies suggest a novel strategy to promote the endogenous pain-resolving role of T cells by sEVs.
El lawfare, entre sus (no)límites y la transdisciplinariedad
Authors: Popa Tache Cristina Elena , Săraru Cătălin-Silviu
Published: August 2023

This research explores the chameleon concept of lawfare and its impact on legal systems and society in general, focusing on the interplay between its (im)boundaries and transdisciplinarity. The analysis focuses on a kaleidoscope of fundamental aspects of justice, including the tactics and strategies used in judicial proceedings, in civil or military conflicts, in the abuse of legal procedures, and in the manipulation of the legal system to achieve illegal ends, in the regulation of law at the global level and nationally, highlighting the different forms this phenomenon can take and its impact on the rule of law and democracy. An important aspect of the research is the analysis of the limits of the law, in the sense that there are certain ethical, legal, and moral restrictions on the abusive use of the legal system, regardless of the circumstances. The conclusions are based on the finding that clearer regulations are needed to protect the integrity of the legal system and to prevent legal abuses, a fact that requires a series of future research, establishing the conditions that mark the transition from legal to illegal. This article has been developed using the method of transdisciplinary introspection, based on primary and secondary data from scientific journals, books, documents, and other publications.
Caderno didático: caminhando para a resiliência no turismo: gestão de crises e desastres
Authors: Sagi Luciana
Published: August 2023

O caderno apresenta um panorama geral de como a gesto de crises e desastres no turismo brasileiro se deu até 2020 e indica caminhos que podem conduzir os destinos turísticos rumo à maior resiliência. Inclui algumas ferramentas, instrumentos e exemplos que poderão orientar a definição de planos, medidas e ações voltadas para aprimorar o processo de gesto de crises e desastres no setor. A publicação tem como objetivo ampliar o conhecimento básico sobre a temática e compartilhar referências internacionais relacionadas com o turismo - tanto conceituais, quanto estudos de caso de sucesso - que muitas vezes estão bem documentadas em idioma inglês, mas no estão facilmente acessíveis para a leitura em português.
Sistemas automáticos de impressões digitais integrando Java e Arduino
Authors: Neto Esequias Aquino Duarte , Job Ricardo De Sousa , Venceslau Amanda Drielly Pires , Silva Samuel Alves da , Lira Valnyr Vasconcelos
Published: August 2023

A biometria digital é a característica biométrica mais difundida e utilizada dentre as demais. Ela utiliza-se das variações das linhas existentes nas pontas dos dedos para determinar a identidade de um indivíduo. Aparentemente trata-se de uma tecnologia futurista, mas a biometria digital foi uma prática adotada pelas civilizações passadas, que as utilizavam para realizar transações comerciais e enviar documentos confidenciais. Com o grande volume de dados, novos métodos que visavam aprimorar o trabalho com impressões digitais foram propostos, mesmo assim todos possuíam dificuldades para armazenar e realizar buscas. Para resolver o problema foram criados os Sistemas Automáticos de Impressões Digitais, que por envolver múltiplas áreas de conhecimento, torna difícil a implementação para os desenvolvedores. Este trabalho apresenta as etapas necessárias que envolvem a implementação dessa tecnologia, afim de tornar o leitor capaz de compreender e desenvolver os processos e o funcionamento de um Sistema Automático de Identificação de Impressões Digitais utilizando a linguagem de programação Java e a plataforma de desenvolvimento Arduino.
THEORETIC FRAMEWORK AND PRACTICAL IMPLEMENTATION
Authors: Bardjieva Miovska Leta , Bakreski Oliver
Published: August 2023

In the scope of its focus, this paper has the critical infrastructure protection in a contemporary setting as a threat for the Euro-Atlantic Values. The awareness for the vulnerability of the critical infrastructure systems, which are additionally threatened by cyber-attacks and communication disruptions, is high on the security assessment and planning agenda for the state’s policy creators and corporate enterprises. The methodology applied for this research consists of qualitative and quantitative methods of data interpretation, gathered by a method of open source analysis, observations, document screening and analysis. The first hypothesis depicted by the data analysis reflects the need for further development of the cyber security platform that incorporates several institutions accounted for critical infrastructure protection and the prevention of tasks overlaps and operational vacuum. This hypothesis refers concretely to the case of the Republic of North Macedonia. The limitations of the findings from this research effort are displayed in the form of lack or insufficient legal framework realization of the prescribed institutional capacity and regulation execution in the domain of critical infrastructure systems protection. A conclusion can be drawn that emphasizes the actual imperative for applying and implementing context-specific and best-alternative solutions in the critical infrastructure protection, delivered by joint engagement of the relevant institutions. Key words: security, cyber, critical infrastructure, protection, planning
Server Setup for Micro Grid and Compatible Systems
Authors: Joshi Sanjeev , Moola Bindhu Reddy , Musham Varsha Bhavani , Jones Jr. Erick
Published: August 2023

This research study presents a cost-effective and efficient solution for setting up a server to manage and monitor microgrid and compatible systems using Raspberry Pi, Docker, Node-RED, InfluxDB, MQTT, and Grafana. The server is built using Raspberry Pi and Docker for a consistent environment, Node-RED for programming the logic and workflows, InfluxDB for storing time-series data, MQTT for messaging, and Grafana for data visualization. The server is tested with a microgrid system consisting of solar panels, battery bank, and inverter, and compatible systems like smart homes and IoT devices. The results demonstrate that this solution provides a scalable and reliable platform for managing and monitoring microgrids and compatible systems. The server can be easily customized and scaled to meet the requirements of different systems, making it an efficient and cost-effective solution for managing and monitoring these systems. In recent years, there has been a growing interest in developing smart grid systems for energy management and monitoring. The use of advanced technologies such as Raspberry Pi, Node-RED, and MQTT has been explored in several research studies.
The Evolution of Supply Chain Transparency through Technology
Authors: Hasan Ikram , Habib Md. Mamun
Published: August 2023

Supply chain transparency is no longer a mere buzzword. In the modern era, transparent supply chains are both a corporate responsibility and a consumer demand. With the rise of conscious consumers, businesses are under increasing pressure to ensure not only the quality but also the ethical sourcing and production of their products. Enter technology: the key driver that has enabled companies to lift the veil off their supply chains and bring about unprecedented levels of visibility and accountability. This article delves into the evolution of supply chain transparency through technology, charting the major milestones and technological innovations that have shaped this transformation.
Deciphering gastric inflammation-induced tumorigenesis through multi-omics data and AI methods
Authors: Zhang Qian , Yang Mingran , Zhang Peng , Wu Bowen , Wei Xiaosen , Li Shao
Published: August 2023

Gastric cancer (GC), the fifth most common cancer globally, remains the leading cause of cancer deaths worldwide. Inflammation-induced tumorigenesis is the predominant process in GC development; therefore, systematic research in this area should improve understanding of the biological mechanisms that initiate GC development and promote cancer hallmarks. Here, we summarize biological knowledge regarding gastric inflammation-induced tumorigenesis, and characterize the multi-omics data and systems biology methods for investigating GC development. Of note, we highlight pioneering studies in multi-omics data and state-of-the-art network-based algorithms used for dissecting the features of gastric inflammation-induced tumorigenesis, and we propose translational applications in early GC warning biomarkers and precise treatment strategies. This review offers integrative insights for GC research, with the goal of paving the way to novel paradigms for GC precision oncology and prevention.
Methodologies for Wind Field Reconstruction in the U-SPACE: A Review
Authors: Bucchignani Edoardo
Published: August 2023

In the present work, the main methodologies used to reconstruct wind fields in the U-SPACE have been analyzed. The SESAR U-SPACE program aims to develop an Unmanned Traffic Management system with a progressive introduction of procedures and services designed to support a secure access to the air space for a large number of drones. The Italian Aerospace Research Center (CIRA) is carrying out the EDUS project focused on the development and validation of operating platform demonstrators serving the micro-scale weather forecasts and the collection of information necessary for the definition of the flight plan of the drones in urban contexts. For this reason, the state of art methodologies that can be used to estimate winds at low altitudes in urban areas starting from available observational data have been reviewed in the present paper. Some of these techniques were originally developed for reconstruction at high altitudes, but successively adapted to treat different heights. A common approach to all techniques is to approximate the probabilistic distribution of wind speed over time with some parametric models, apply spatial interpolation to the parameters and then read the predicted value.
Bioactive Functions of Lipids in Milk Fat Globule Membrane: A Comprehensive Review
Authors: Pan Junyu , Chen Meiqing , Li Ning , Han Rongwei , Yang Yongxin , Zhao Shengguo , Zheng Nan , Zhang Yangdong
Published: August 2023

Milk fat globule membrane (MFGM) is a complex tri-layer membrane that wraps droplets of lipids in milk. In recent years, it has attracted widespread attention due to its excellent bioactive functions and nutritional value. The milk fat globule membrane contains a diverse array of bioactive lipids, including cholesterol, phospholipids, and sphingolipids, which play pivotal roles in mediating the bioactivity of the milk fat globule membrane. We sequentially summarize the main lipid types in milk fat globule membrane in this comprehensive review and outline the characterization methods used to employed them. In this comprehensive review, we sequentially describe the types of major lipids found in the milk fat globule membrane and outline the characterization methods employed to study them. Additionally, we compare the structural disparities among glycerophospholipids, sphingolipids, and gangliosides, while introducing the formation of lipid rafts facilitated by cholesterol. The focus of this review revolves around an extensive evaluation of current research on lipid isolates from the milk fat globule membrane, as well as products containing milk fat globule membrane lipids, with respect to their impact on human health. Notably, we emphasize clinical trials encompassing a large number of participants. The summarized bioactive functions of milk fat globule membrane lipids encompass regulation of human growth and development, influence on intestinal health, inhibition of cholesterol absorption, enhancement of exercise capacity, and anti-cancer effects. By offering a comprehensive overview, the aim of this review is to provide valuable insights into the diverse biologically active functions exhibited by lipids in milk fat globule membrane.
Assessing the Current Performance of ChatGPT and the Implications in the Academic and Scientiﬁc Community: Failures, Misuse, and Challenges
Authors: Pech-Rodríguez Wilian Jesús , Armendáriz-Mireles Eddie Nahúm , Calles-Arriaga Carlos Adrián , Rodríguez-Garcia José Amparo , Rocha-Rangel Enrique
Published: August 2023

Herein are reported the main pros and cons of using the conversational Artificial Intelligence (AI) called “ChatGPT” as a tool to write essays in the academic and scientific community. Also, selected mathematical and scientific problems were solved to determine the effectiveness of this platform. To this end, a systematic case study was designed and conducted to obtain data generated by the chatbot that was further analyzed. Six different topics were chosen for the essay evaluation, and the introduction section was created using this AI. Meanwhile, six mathematical problems related to integrals, z-transform, Laplace transform, and resolution of ordinary differential equations were solved. Furthermore, a scientific problem associated with the structural properties of material was also solved. After data analysis, we concluded that the conversational platform could quickly create written essays with well-structured words. Nonetheless, in almost all cases, the chatbot only used basic information to complete the introduction, and no critical writing was obtained. For the mathematical case study, we observed that under the current status of the ChatGPT, this platform has no ability or skills to solve complex equations. Thus, significant changes need to be conducted to improve the performance of ChatGPT for mathematical solutions.
Enhancing the Electrochemical Cycle Stability of Prussian-Blue Based Li-ion Storage Cathodes by the Incorporation of Ag and Ni Nanoparticles
Authors: Li Wen-Hsien , Batsaikhan Erdembayalag , Ma Ma-Hsuan , Yang Chun Chuen
Published: August 2023

Taking advantage of fact that the surface electrons of metallic nanoparticles (NPs) can be effectively released even at a low voltage bias, we demonstrate an improvement in the electrochemical performance of nano-sized Prussian Blue (PB) based secondary batteries by the incorporation of bare Ag or Ni NPs onto the vicinity of the working PB NPs. It is found that the capacity for electrochemical energy storage of the 17-nm-PB-based battery is significantly higher than the capacity of 10-nm-PB-based, 35-nm-PB-based or 46-nm-PB-based batteries. There is a critical PB size for the highest electrochemical energy storage efficiency. The full specific capacity CF of the 17-nm-PB-based battery stabilized to 62 mAh/g after 130 charge-discharge cycles at a working current of IW = 0.03 mA. The addition of 14 mass-percent of Ag NPs in the vicinity of the PB NPs gives rise to a 32% increase in the stabilized CF. A 42% increase in the stabilized CF can be obtained with the addition of 14 mass-percent of Ag NPs on the working electrode of the 35-nm-PB-based battery. An enhancement of CF is also found for electrodes incorporating bare Ni NPs but the effect is smaller.