bluuebunny/crossref_metadata_2025 huggingface dataset:
Work interruptions of office workers: The influence of the complexity of primary work tasks on the perception of interruptions
Authors: Rick Vera B. , Brandl Christopher , Mertens Alexander , Nitsch Verena
Published: July 2023

BACKGROUND: Research demonstrates that work interruptions are considered one of the most common work stressors. Understanding the mechanisms of work interruptions is therefore vital to reducing worker stress and maintaining performance. OBJECTIVE: The aim of this research is to investigate the influence of the frequency of work interruptions on subjective workload in the context of office work. Specifically, the mediating influence of interruption perception as well as the moderating influence of the complexity of the primary task are examined. METHOD: The work interruptions of 492 office workers in Germany were collected by means of a one-day diary study. A mediation model and a conditional indirect effect model were calculated to examine the influence of interruption frequency on subjective workload, mediated by the individual perception of these interruptions as well as moderated by the complexity of the primary work tasks. RESULTS: The analyses indicated a significant mediation and moderation. This implies that, on the one hand, the perception of work interruptions significantly mediates the relationship between the frequency of work interruptions and subjective workload. On the other hand, more complex primary work tasks seem to strengthen the positive relationship between interruption frequency and perceived interruption overload. CONCLUSION: The study underlines that work interruptions need to be considered in a much more differentiated way than is currently the case. Both in research and in terms of intervention measures in the work context, the various influencing factors need to be identified for an assessment of the effects on the working person to be possible.
Job stressors and turnover intention of IT executives in Malaysia: The mediating role of employee well-being
Authors: Langove Naseebullah , Javaid Muhammad Umair , Ayyasamy Ramesh Kumar , Ibikunle Afeez Kayode , Sabir Asrar Ahmed
Published: July 2023

BACKGROUND: Fear of losing psychological resources can lead to stress, impacting psychological health and behavioral outcomes like burnout, absenteeism, service sabotage, and turnover. OBJECTIVE: The study examined the impact of job stressors (time pressure, role ambiguity, role conflict) on employee well-being and turnover intentions. The study also investigated the mediating role of employee well-being between job stressors and turnover intention based on the conservation of resources (COR) theory. METHODS: Data from 396 IT executives in Malaysian IT firms were analyzed using the Partial Least Squares - Structural Equation Modeling (PLS-SEM) technique. RESULTS: Results confirmed a significant negative correlation between time pressure (–0.296), role ambiguity (–0.423), role conflict (–0.104), and employee well-being. Similarly, employee well-being showed a significant negative relationship with turnover intentions (–0.410). The mediation analysis revealed that employee well-being mediates the relationship between time pressure (0.121), role ambiguity (0.173), role conflict (0.043), and turnover intentions. CONCLUSION: This paper aims to manifest the importance of designing employee well-being policies by firms to retain employees. Findings reflect the role of the managerial approach towards ensuring employee well-being for employee retention, thereby reducing recruitment and re-training costs.
Compressive Behavior of Reconstituted Soils at High Initial Water Content: Case Study on South-Western Region Of Bangladesh
Authors: Riyad A S M , Rafizul Islam M , Kadir Rezwana
Published: July 2023

This study illustrates the experimental investigation of the effect of high initial water content on the compression behavior of reconstituted soil. For this attempt, disturbed soil samples were collected from two selected locations of the KUET campus, Khulna, Bangladesh. The reconstituted soils were prepared in the laboratory at different initial water content, ranging from 0.7 to 1.2 times their corresponding liquid limit. The main focus of this study was to investigate the compression behavior of reconstituted clays using oedometer tests. This work was complementary to the intrinsic compression line concept proposed by Burland (1990). In the laboratory, ASTM methods were followed to measure the initial properties of soils. Here, it can be observed that e - logσv compression curves show an inverse "S" shape as a result of resisting deformation due to pressure. Moreover, some important correlations were developed based on the initial void ratio and the void ratio at the liquid Limit e0/eL . It has been observed that the void index is a dominating parameter to normalize the squeezability characteristics at different initial water contents in the plastic post-yield regime. A non-unique relationship is obtained for different soils to express the intrinsic compression line concept. However, there is a proportional relationship between intrinsic compressibility and initial water contents or liquid limits.
Journal of Engineering Science 14(1), 2023, 1-9
Digital-Based Islamic Religious Education (IRE) Learning Model at Senior High School
Authors: Nasaruddin Abdul Halik , Das St. Wardah Hanafie , Ladiqi Suyatno
Published: July 2023

Contemporary learning trends lead to digital implementation. Digitalization of learning has implications for the effectiveness and efficiency of achieving learning objectives. Demand and need for implementing digital-based learning in Moral and Islamic Religious Education (Pendidikan Agama Islam dan Budi Pekerti, PAI dan BP) because the students are millennials. Digital-based learning design includes objectives, teaching materials, digital media, methods, and evaluation (assessment tools). This study aimed to find a digital-based learning model for PAI and BP subjects at senior high schools. This type of research was qualitative. Observation, interviews, and document studies carried out techniques of data collection. Data was collected through various settings, sources, and methods. Data analysis techniques used data condensation, information disclosure, and conclusion. The study results showed that the digital-based Islamic religious learning approach was scientific and student-centered; Islamic religious learning used Google Classroom, assisted by WhatsApp. Teaching materials were designed as power points, pdf books, and videos. The digital learning model with a student-centered approach has several indicators, including interactive digital learning strategies, lecture methods, assignments, simulations, inquiry, and Islamic religious learning-specific scenarios, namely habituation, exemplary, praise, and threats. Learning techniques use WhatsApp, connected to other social media such as Facebook and Instagram. Learning tactics through humor, singing, rhetoric, and surprise. The implications of implementing digital-based learning models can create a learning atmosphere that encourages students to be more interactive, foster creativity, and develop independent learning.
Role of the membrane-spanning 4A gene family in lung adenocarcinoma
Authors: Zheng Zijun , Li Huiping , Yang Runjiao , Guo Hui
Published: July 2023

Lung adenocarcinoma, which is the second most prevalent cancer in the world, has a poor prognosis and a low 5-year survival rate. The MS4A protein family is crucial to disease development and progression, particularly for cancers, allergies, metabolic disorders, autoimmune diseases, infections, and neurodegenerative disorders. However, its involvement in lung adenocarcinoma remains unclear. In this study, we found that 11 MS4A family genes were upregulated or downregulated in lung adenocarcinoma. Furthermore, we described the genetic variation landscape of the MS4A family in lung adenocarcinoma. Notably, through functional enrichment analysis, we discovered that the MS4A family is involved in the immune response regulatory signaling pathway and the immune response regulatory cell surface receptor signaling pathway. According to the Kaplan–Meier curve, patients with lung adenocarcinoma having poor expression of MS4A2, MS4A7, MS4A14, and MS4A15 had a low overall survival rate. These four prognostic genes are substantially associated with immune-infiltrating cells, and a prognosis model incorporating them may more accurately predict the overall survival rate of patients with lung adenocarcinoma than current models. The findings of this study may offer creative suggestions and recommendations for the identification and management of lung adenocarcinoma.
Epidermal growth factor alters silica nanoparticle uptake and improves gold-nanoparticle-mediated gene silencing in A549 cells
Authors: Susnik Eva , Bazzoni Amelie , Taladriz-Blanco Patricia , Balog Sandor , Moreno-Echeverri Aura Maria , Glaubitz Christina , Brito Oliveira Beatriz , Ferreira Daniela , Viana Baptista Pedro , Petri-Fink Alke , Rothen-Rutishauser Barbara
Published: July 2023

Introduction: Delivery of therapeutic nanoparticles (NPs) to cancer cells represents a promising approach for biomedical applications. A key challenge for nanotechnology translation from the bench to the bedside is the low amount of administered NPs dose that effectively enters target cells. To improve NPs delivery, several studies proposed NPs conjugation with ligands, which specifically deliver NPs to target cells via receptor binding. One such example is epidermal growth factor (EGF), a peptide involved in cell signaling pathways that control cell division by binding to epidermal growth factor receptor (EGFR). However, very few studies assessed the influence of EGF present in the cell environment, on the cellular uptake of NPs.

Methods: We tested if the stimulation of EGFR-expressing lung carcinomacells A549 with EGF affects the uptake of 59 nm and 422 nm silica (SiO2) NPs. Additionally, we investigated whether the uptake enhancement can be achieved with gold NPs, suitable to downregulate the expression of cancer oncogene c-MYC.

Results: Our findings show that EGF binding to its receptor results in receptor autophosphorylation and initiate signaling pathways, leading to enhanced endocytosis of 59 nm SiO2 NPs, but not 422 nm SiO2 NPs. Additionally, we demonstrated an enhanced gold (Au) NPs endocytosis and subsequently a higher downregulation of c-MYC.

Discussion: These findings contribute to a better understanding of NPs uptake in the presence of EGF and that is a promising approach for improved NPs delivery.
A multicentre study on the clinical characteristics of newborns infected with coronavirus disease 2019 during the omicron wave
Authors: Dai Yi-Heng , Li Caihuan , Yuan Guilong , Mo Wenhui , Chen Jun , Huang Runzhong , Wan Zhonghe , Lin Duohua , Zhong Xiangming , Li Huanqiong , Liu Ling , Shi Jipeng
Published: July 2023

Objective

To investigate the clinical characteristics and outcomes of newborns infected with coronavirus disease 2019 (COVID-19) during the Omicron wave.

Methods

From December 1, 2022, to January 4, 2023, clinical data were collected from neonates with COVID-19 who were admitted to 10 hospitals in Foshan City, China. Their epidemiological histories, clinical manifestations and outcomes were analysed. The neonates were divided into symptomatic and asymptomatic groups. The t test or χ2 test was used for comparisons between groups.

Results

A total of 286 children were diagnosed, including 166 males, 120 females, 273 full-term infants and 13 premature infants. They were 5.5 (0–30) days old on average when they were admitted to the hospital. These children had contact with patients who tested positive for COVID-19 and were infected through horizontal transmission. This study included 33 asymptomatic and 253 symptomatic patients, among whom 143 were diagnosed with upper respiratory tract infections and 110 were diagnosed with pneumonia. There were no severe or critical patients. Fever (220 patients) was the most common clinical manifestation, with a duration of 1.1 (1–6) days. The next most common clinical manifestations were cough with nasal congestion or runny nose (4 patients), cough (34 patients), poor appetite (7 patients), shortness of breath (15 patients), and poor general status (1 patient). There were no significant abnormalities in routine blood tests among the neonates infected with COVID-19 except for mononucleosis. However, compared with the asymptomatic group, in the symptomatic group, the leukocyte and neutrophil granulocyte counts were significantly decreased, and the monocyte count was significantly increased. C-reactive protein (CRP) levels were significantly increased (≥10 mg/L) in 9 patients. Myocardial enzyme, liver function, kidney function and other tests showed no obvious abnormalities.

Conclusions

In this study, neonates infected with the Omicron variant were asymptomatic or had mild disease. Symptomatic patients had lower leucocyte and neutrophil levels than asymptomatic patients.
Using the Baidu index to predict trends in the incidence of tuberculosis in Jiangsu Province, China
Authors: Wang Yue , Zhou Haitao , Zheng Li , Li Min , Hu Bin
Published: July 2023

Objective

To analyze the time series in the correlation between search terms related to tuberculosis (TB) and actual incidence data in China. To screen out the “leading” terms and construct a timely and efficient TB prediction model that can predict the next wave of TB epidemic trend in advance.

Methods

Monthly incidence data of tuberculosis in Jiangsu Province, China, were collected from January 2011 to December 2020. A scoping approach was used to identify TB search terms around common TB terms, prevention, symptoms and treatment. Search terms for Jiangsu Province, China, from January 2011 to December 2020 were collected from the Baidu index database.1 Correlation coefficients between search terms and actual incidence were calculated using Python 3.6 software. The multiple linear regression model was constructed using SPSS 26.0 software, which also calculated the goodness of fit and prediction error of the model predictions.

Results

A total of 16 keywords with correlation coefficients greater than 0.6 were screened, of which 11 were the leading terms. The R2 of the prediction model was 0.67 and the MAPE was 10.23%.

Conclusion

The TB prediction model based on Baidu Index data was able to predict the next wave of TB epidemic trends and intensity 2 months in advance. This forecasting model is currently only available for Jiangsu Province.
Establishing community mental health clinics increased the number of patients receiving care in rural Western Uganda
Authors: Kuule Yusufu , Dobson Andrew E. , Mutahunga Birungi , Stewart Alex G. , Wilkinson Ewan
Published: July 2023

Background

Mental, neurological, and substance-use disorders cause medium to long term disability in all countries. They are amenable to treatment but often treatment is only available in hospitals, as few staff feel competent to give treatment. The WHO developed the “Mental Health GAP” (mhGAP) course to train non-specialist clinical staff in basic diagnosis and treatment. At Bwindi Community Hospital, in south-west Uganda, mental health care was initially only provided at the hospital. It was extended outside the hospital in two implementation phases, initially by establishing 17 clinics in the community, run by qualified mental health staff from the hospital. In the second implementation phase staff in 12 health centers were trained using mhGAP and ran their own clinics under supervision.

Methods

Using routine data the defined data variables for the individuals attending the clinics was extracted.

Results

A total of 2,617 people attended a mental health care clinic in the study period between January 2016 and March 2020. Of these 1,051 people attended more than once. The number of patients attending clinics increased from 288 during the baseline to 693 in the first implementation phase then to 839 patients in the second implementation phase. After mhGAP training, about 30% of patients were seen locally by mhGAP trained healthcare personnel. The average number of mental health patients seen each month increased from 12 to 65 over the time of the study. The number of patients living >20 km from the hospital increased from 69 in the baseline to 693 in the second implementation phase. The proportion of patients seen at the hospital clinic dropped from 100% to 27%.

Conclusions

Providing mental health care in the community at a distance from the hospital substantially increased the number of people accessing mental health care. Training health center-based staff in mhGAP contributed to this. Not all patients could appropriately be managed by non-specialist clinical staff, who only had the five-day training in mhGAP. Supplies of basic medicines were not always adequate, which probably contributed to patients being lost to follow-up. About 50% of patients only attend the clinic once. Further work is required to understand the reasons.
Revisiting Estrogen for the Treatment of Endocrine-Resistant Breast Cancer: Novel Therapeutic Approaches
Authors: Shete Nivida , Calabrese Jordan , Tonetti Debra A.
Published: July 2023

Estrogen receptor (ER)-positive breast cancer is the most common subtype, representing 70–75% of all breast cancers. Several ER-targeted drugs commonly used include the selective estrogen receptor modulator (SERM), tamoxifen (TAM), aromatase inhibitors (AIs) and selective estrogen receptor degraders (SERDs). Through different mechanisms of action, all three drug classes reduce estrogen receptor signaling. Inevitably, resistance occurs, resulting in disease progression. The counterintuitive action of estrogen to inhibit ER-positive breast cancer was first observed over 80 years ago. High-dose estrogen and diethylstilbestrol (DES) were used to treat metastatic breast cancer accompanied by harsh side effects until the approval of TAM in the 1970s. After the development of TAM, randomized trials comparing TAM to estrogen found similar or slightly inferior efficacy but much better tolerability. After decades of research, it was learned that estrogen induces tumor regression only after a period of long-term estrogen deprivation, and the mechanisms of tumor regression were described. Despite the long history of breast cancer treatment with estrogen, this therapeutic modality is now revitalized due to the development of novel estrogenic compounds with improved side effect profiles, newly discovered predictive biomarkers, the development of non-estrogen small molecules and new combination therapeutic approaches.
SOLID PSEUDOPAPILLARY NEOPLASM OF PANCREAS- CASE SERIES
Authors: Kamalraj. M. , K Gowtham. , S. Shanthi P.
Published: July 2023

The prevalence of solid pseudopapillary neoplasms (SPN) of the pancreas is highest in the second and third decade and primarily affects young women. SPN was classied as a rare "low grade malignant pancreatic tumour" in the 2019 WHO classication of malignancies of the digestive system. SPT has a good prognosis and is generally passive. Most common location in adults is body and tail, whereas it is head of the pancreas in children. Usually occurs as a single large mass. The gold standard investigation of choice is contrast enhanced computed tomography (CECT). Primary surgical resection is considered as the treatment of choice for SPNs. The procedure will depend on the location of the tumor. Cytohistologic examination with immunohistochemistry is required to conrm the diagnosis. Patients usually do well with a 5-year survival rate of about 97%. In this article we discuss the presentation, diagnosis, and treatment modalities of three cases of solitary pseudopapillary neoplasm of pancreas.
A PROSPECTIVE STUDY OF FUNCTIONAL OUTCOME OF LISFRANC INJURIES TREATED BY FLUOROSCOPIC GUIDED CLOSED REDUCTION AND PERCUTANEOUS FIXATION
Authors: Reddy Ramasubba , H Prakashappa T , Swamy S H Manjunatha , M Kaginele Shravan
Published: July 2023

Objective: To assess functional outcomes and postoperative complications of Lisfranc fracture dislocation treated at our institute with closed reduction and percutaneous xation using K wire and CC screws. It is a prospective Methodology: study conducted at 'Department of Orthopaedics', Sanjay Gandhi Institute of Trauma and Orthopaedics, Bangalore. This study included 30 cases between JAN 2021 – JULY 2022 treated by uoroscopic guided closed reduction and percutaneous xation. Functional outcomes were assessed using AOFAS Score. Out of Result: 30 patients, 93.3% had good outcome, 6.7% had fair outcome and none of the patient had poor outcome at the 1year follow-up. Mean AOFAS score was 77.10 ± 4.93. Closed reduction and percutaneous xation of Lisfranc fracture dislocati Conclusion: on using K wire and CC screws is a minimally invasive procedure and majority have good functional outcome.
ПЕРЕДУМОВИ ЗАБЕЗПЕЧЕННЯ ЕНЕРГЕТИЧНОЇ АВТОНОМНОСТІ ПІДПРИЄМСТВ АКВАКУЛЬТУ-РИ
Authors: Четверик Г. О. , Яременко О. А. , Голуб Г. А.
Published: July 2023

Набуває поширення використання рециркуляційних систем водопостачання для розведення прісноводної риби. Важливим і актуальним є забезпечення енергетичної автономності таких систем. Одним із способів енергетичного використання від­ходів рибних господарств є метанове зброджування осадів стічних вод підприємств аквакультури. Метою роботи є оцінка можливості виробництва біогазу із осадів стічних вод в аквакультурі для забезпечення часткової енергетичної автономності рециркуляційних систем водопостачання. Стаття присвячена аналізу сучасного стану досліджень метанового зброджування осадів стічних вод рециркуляційних систем водопостачання. Аналіз виконано на основі наукових публікацій в даному напрямку та власних досліджень. Наведено аналіз технічних рішень для систем штучного вирощування риби з використанням біогазу. Встановлено, що осад стічних вод рибних господарств є перспек-тивною сировиною для отримання біогазу, що дає змогу досягнути часткової автономності рециркуляційних систем водопостачання. Бібл. 48, рис. 4.
HIDROLISIS PROTEIN TINTA CUMI-CUMI (Loligo sp) DENGAN ENZIM PAPAIN
Authors: Kurniawan Kurniawan , Lestari Susi , R. J. Siti Hanggita
Published: July 2023

The objective of this research were to know yield, protein content, free Î±-amino nitrogen, degree of hydrolysis, and amino acid of the result hydrolysis of ink protein squid (Loligo sp) with papain enzyme. The research used the method completely randomized design with two replications of the treatment factors, the difference in the concentration of the papain enzyme (0%, 1%, 2%, 3%, 4%, 5%, and 6%). The parameters of research were yield, protein content, free Î±-amino nitrogen, degree of hydrolysis, and amino acids. The results of research showed that differences in the concentration papain enzyme significant effect on the value of yield, protein content, free Î±-amino nitrogen, and degree of hydrolysis. Yield ranges from 78.05% to 88.61%, protein content from 28.90 mg/ml to 36.31 mg/ml, free Î±-amino nitrogen from 0.49 mg/ml to 10.99 mg/ml, the degree of hydrolysis from 0.016 to 0.345, and contains 14 kinds of amino acids of the 15 amino acids analyzed, histidine, arginine, threonine, valine, isoleucine, leucine, phenylalanine, lysine, glutamic acid, aspartic acid, serine, glycine, alanine, and tyrosine. The content of amino acid and degree of hydrolysis highest contained in the P2 treatment (papain enzyme concentration of 2%).
PENGGUNAAN MEDIA FLASHCARD DALAM MENGATASI KESULITAN MEMBACA SISWA DISELEKSIA
Authors: Ike Komariah  , Dadang Kurnia  , Nurlinda Safitri
Published: July 2023

Penggunaan media flashcard dalam mengatasi kesulitan membaca siswa disleksia  Penelitian ini merupakan penelitian kualitatif.dengan pendekatan studi kasus. Prosedur pengumpulan dan perekaman data dilakukan melalui observasi, wawancara dan dokumentasi. Teknik pengumpulan data dilakukan dengan tahap reduksi data, penyajian data dan verivikasi (penarikan kesimpulan).  Hasil penelitian menunjukkan bahwa: (1) Pengguna media flahcard yang dilakukan saat bimbingan belajar dapat digunakan untuk mengatasi kesulitan belajar membaca siswa disleksia. Perkembangan yang dialami oleh subjek yaitu subjek sudah mulai bisa mengenal dan melafalkan huruf, baik itu huruf kapital maupun kecil. Subjek juga mulai mengerti cara membedakan bentuk /bunyi huruf yang mirip seperti huruf “B” dan “D”, “M” dan “W” “N” dan “U” “P” dan “Q” (1) Faktor penyebab yang mempengaruhi kenyataan membaca disleksia siswa yaitu saat subyek berusia satu minggu subjek mengalami panas yang cukup tinggi sehingga harus dirawat di rumah sakit selama satu bulan itu merupakan faktor internal dari subjek. Sedangkan faktor eksternal berupa kurang perhatiannya dari orang tua atau rasa lalai mempelajari subjek ketika di rumah karena sering bermain handphone yang cukup lama. Maka dapat disimpulkan bahwa media flashcard dapat digunakan untuk mengatasi kesulitan belajar siswa membaca disleksia dan faktor penyebab kesulitan membaca siswa pada setiap terdiri dari faktor internal dan faktor eksternal.
A insulina no processo de emagrecimento
Authors:   Humberto Augusto de Abreu Frazão, Guilherme Prado Drosdosky, Maria Clara Torres Cabral, Débora Fernandes Barros Cabral, Laura de oliveira Carvalho, Gabriel de Oliveira Landim, Juliane Alessa Simões Rebelo, Síntique Oliveira Soares, João Ricardo Herenio de Melo, Miguel MarconSavorettePassarelli, Larissa Bossatto Silva, Hiasmyn Genoveva Macherine de Souza, Raphael Alexandre Galletti and Livia Melo Carmago
Published: July 2023

A insulina, tem função reguladora da entrada de glicose em todos os tecidos, com exceção do cérebro, por meio da difusão facilitada. Nesse sentido, a insulina tem como ação a inibição da lipólise, promovendo a síntese de glicogênio, proteína e gordura, resultando em efeitos anabólicos. Todavia, este trabalho tem como objetivo principal demonstrar por meio de trabalhos já publicados, a relação da insulina no processo de emagrecimento, além de demonstrar os riscos e benefícios de tal fato. Trata-se de uma revisão integrativa da literatura, no modelo descritivo analítico. Diante do exposto, pôde-se concluir a necessidade do acompanhamento de uma equipe multidisciplinar no processo de emagrecimento, sendo composta principalmente por nutricionistas, médicos, enfermeiros, psicólogos e assistentes sociais para uma prestação de uma assistência humanizada e eficaz.
General Review on Opioids
Authors: Al-Onizi Areej D , A Abu-hasabu Bashaer , Al-Hwaiti Dalal N , Al-Ali Ro’aa M , Al-Madani Norah M , El Rabey Haddad A
Published: July 2023

Opioids are widely utilized by the public as both legal and illegal substances. Opiates, particularly heroin, are among the most widely used illicit narcotics and still account for the majority of seizures globally, despite the development of Novel Psychoactive Substances (NPS), particularly new fentanyl derivatives. The article gives a general review of opiates' pharmacology, analgesic action, and classification. It discussed how they might be abused by the general public and in the event of tampering. Because of the hazards of accidents linked to opiate use and dependence, opiates are furthermore closely monitored in workplace drug testing programs around the world. Also it covered analytical techniques for opiate detection in biological fluids. In the modern era, substance abuse has emerged as a global epidemic. Opium and its derivatives are second only to cannabis in terms of global consumption among illegal narcotics.
Development of a New Anti-Rabies Antiviral: Effective Treatment with Beclin-1 and Lifespan Prolongation
Authors: Parizad Homeira , Abdoli Asghar , Mostafavi Ehsan , Sheikholeslami* Farzaneh
Published: July 2023

Autophagy is a cellular mechanism that exerts antiviral effects in some virus-infected cells, while it can have opposite effects on some other cells. Rabies is an infectious disease caused by negative-stranded RNA virus. After the street Rabies Virus (RABV), the vector containing Beclin-1 were injected into the brains of mice. They were sacrificed to collect the samples. Next, the focus forming assay, TUNEL assay and q PCR were performed. The expression of MAP1LC3B, ATG5, and BECN1 genes and the relative mRNA expression of autophagy-related genes increased after in vivo transfection of the pIRES2-EGFP-Beclin-1 vector in test groups (p < 0.01). The number of viruses decreased in the brains of test group compared to the controls. Survival significantly increased in mice treated with the Beclin-1 containing vector compared to controls. The TUNEL assay did not indicate apoptosis. LC3 was notably expressed in the brain samples that were previously transfected with the pIRES-EGFP-Beclin-1 vector.
Mushrooms and Lichens the Factory of Important Secondary Metabolites: Review
Authors: Elkhateeb Waill A , El-Ghwas Dina E , GM Daba
Published: July 2023

Mushrooms and lichens are plentiful source of nutritional and medicinal compounds. However, medicinal uses of the mushrooms and lichens still need to be worked out for their biological activities. Mushrooms and Lichens have reserved their position centuries ago as food and medicine. They are rich in nutrients and in biologically active compounds that belong to different chemical classes. Capabilities of different members of mushrooms and Lichens have encouraged researchers to investigate further applications of these macrofungi and lichens in fields of food and pharmaceutical industries and also other than food and pharmaceutical industries. This review, aims to put together Lentinan, schizophyllan, Betulinans A and B, ganoderic acid, cordycepin and usnic acid under light spot through representing their importance as biological activities exerted by ever one. Further studies and investigations are fortified in order to find more about these interesting natural products.
Incidence and Features of Lymphoid Proliferation and Lymphomas after Solid Organ or Hematopoietic Stem Cell Transplantation in a National Database Cohort
Authors: Hahn Seung Min , Lee Myeongjee , Hyun JongHoon , Lim Sungmin , Kang Ji-Man , Ahn Jong Gyun , Joo Dong Jin , Jung Inkyung , Ihn Kyong
Published: July 2023

Purpose Post-transplantation lymphoproliferative disorders (PTLDs) after hematopoietic stem transplantation (HCT) or solid organ transplantation (SOT) result in poorer outcomes, including death. There are limited large cohort data on the incidence and natural course of PTLD in Asians.Materials and Methods We investigated PTLD using Korean national health insurance claims data of 47,518 patients who underwent HCT or SOT in 2008-2020. Patient demographics, time and type of PTLD diagnosis, type of PTLD treatment, and death data were collected. We used Fine and Gray subdistribution hazard models to calculate the cumulative incidence and risk factors for PTLD.Results During median follow-up of 5.32 years, PTLD occurred in 294 of 36,945 SOT patients (0.79%) and 235 of 10,573 HCT patients (2.22%). Cumulative incidence of PTLD were 0.49% at 1 year, 1.02% at 5 years, and 1.50% at 10 years post-transplantation. Age < 20 years (subdistribution hazard ratio [SHR] of 1.67 in age 10-19, SHR 1.51 in age 0-9), HCT (SHR 3.02), heart transplantation (SHR 2.27), and liver transplantation (SHR 1.47) were significant risk factors for PTLD. The presence of PTLD was associated with an increased risk of death (hazard ratio of 2.84). Overall, 5-year survival of PTLD patients was 68.9% (95% confidence interval, 64.9 to 73.2).Conclusion We observed a steady increase in PTLD over 10 years after HCT or SOT in this large cohort study. Pediatric age group, HCT, liver transplantation, and heart transplantation were suggested to be risk factors for PTLD, and PTLD was associated with a higher risk of death.
Radina Vučetić, Nevidljivi neprijatelj, variola vera 1972. Beograd: Službeni glasnik, 2022, 299 str.
Authors: Jakubović Fikreta
Published: July 2023

Book Review
Riječ urednika / Word of the Editor
Authors: Duranović Amir
Published: July 2023

Foreword
Theoretical Aspects of Predicting the Results of Development of the Armed Forces’ Capabilities, Considering the Assessments of Sufficiency of the State’s Economic Capabilities Based on the Mathematical Apparatus of S-shaped Functions
Authors: Semenenko Oleh
Published: July 2023

"The purpose of the study is to formulate an improved algorithm for drawing up plans for the development and strengthening of the capacities of the Armed Forces of Ukraine, especially under conditions of limited resources and unforeseen circumstances. The mathematical method is a central for studying and predicting the dynamics of Armed Forces of Ukraine development, namely the calculations carried out using the apparatus of S-shaped functions. In addition, the following methods were also used: analysis, synthesis and abstraction. As a result of the study, it was proposed the models for development of the Armed Forces of Ukraine for the medium term (6 years) and long term (12 years) prospects, considering the previous experience and unforeseen circumstances. It was proposed a system of consistent planning for the Armed Forces development. The key problem in the development and planning of the Ukrainian army is the fact that the expected results do not correspond to the planned ones. It was found a direct correlation between the demands of military system and the capabilities of socio-economic system." 10.46852/0424-2513.2s.2023.3
PERAN GURU DALAM MENINGKATKAN MOTIVASI BELAJAR SISWA PADA MATA PELAJARAN TEMATIK MUATAN SBDP KELAS V DI SDN 82 TOKINJONG
Authors: Akhmad Mawadda Warahma , Danial  , Hardianti  , Islamia Nur , Haq Dziaul
Published: July 2023

The purpose of this study is to find out the thematic learning process for class V at SDN 82 Tokinjong and what is the role of the teacher when teaching, and finally, what motivation does the teacher give to students, this research is qualitative in nature, data collection techniques use observation, interviews, and the research subject was a class V teacher as well as the principal at SDN 82 Tokinjong. Data analysis techniques in the form of data reduction, and data presentation, as well as drawing conclusions. The results of this study indicate that: The teacher's role in the thematic subjects of SBDP content plays a role in making lesson plans, methods, evaluation of learning, but there are several other teacher roles such as motivators, mediators, and evaluators in the thematic learning process that have not been implemented too much so that it has not been implemented efficiently and effectively, in terms of motivating the teacher is still not very motivating students, this can be seen when before the teacher starts the thematic learning process of SBDP content the teacher immediately applies the lecture method and does not provide motivation or in the form of support, the teacher also has not implemented an open attitude to some of his students during the learning process took place, and also the teacher had not implemented some of his roles in motivating his students to be more active during the SBDP thematic learning process that was taking place.
ĐÁNH GIÁ ĐỘ VỮNG ỔN CỦA IMPLANT VÙNG SAU HÀM DƯỚI TRÊN BỆNH NHÂN CÓ SỬ DỤNG HỆ THỐNG MÁNG HƯỚNG DẪN PHẪU THUẬT IN 3D TẠI BỆNH VIỆN TRƯỜNG ĐẠI HỌC Y DƯỢC CẦN THƠ NĂM 2021-2022
Authors: Lê Nguyên Lâm , Nguyễn Võ Đăng Quang
Published: July 2023

Đặt vấn đề: Sự vững ổn của implant là tình trạng không lung lay implant trên lâm sàng, đây cũng là định nghĩa được đề xuất cho khái niệm tích hợp xương. Đạt được và duy trì sự vững ổn của implant là một trong những điều kiện tiên quyết để đạt được thành công trong điều trị phục hình trên implant.Một implant vững ổn có thể biểu hiện độ vững ổn khác nhau (nghĩa là mức độ di lệch hay kháng lại lực khác nhau), tùy thuộc vào những yếu tố liên quan đến xương, kĩ thuật phẫu thuật và thiết kế implant. Mục tiêu: đánh giá sự vững ổn của implant sau  điều trị implant vùng cối lớn 1, 2 hàm dưới trên bệnh nhân có sử dụng hệ thống máng hướng dẫn phẫu thuật in 3d ngay sau cấy và sau 3 tháng. Đối tượng và phương tiện nghiên cứu: Tất cả các implant đều được thực hiện phẫu thuật tại Khoa Răng Hàm Mặt – Bệnh viện Trường Đại học Y Dược Cần Thơ từ tháng 3/2021 đến tháng 6/2022. Phương tiện nghiên cứu- Máy chụp CBCT hiệu Galileos của hãng Sirona, Đức, đĩa lưu hình ảnh CBCT của bệnh nhân dưới dạng dữ liệu DICOM. Hệ thống quét Trios 3 để chuyển dữ liệu mẫu hàm thành dữ liệu kỹ thuật số với định dạng dữ liệu STL (standard template library). Phần mềm Blue Sky Plan dùng để thiết kế máng hướng dẫn phẫu thuật cấy ghép implant nha khoa. Kết quả: Sự khác biệt về lực vặn implant theo giới tính, mật độ xương, đường kính và chiều dài implant không có ý nghĩa thống kê (p>0,05). Độ vững ổn implant trung bình tại thời điểm ngay sau khi phẫu thuật giá trị trung bình là 74,39 ISQ, tất cả đều > 60 ISQ, trong đó nhóm ≥70 ISQ chiếm đa số với 27 vị trí chiếm 84,4%, tiếp theo là nhóm 65 – 69 ISQ với 3 vị trí chiếm 9,4%. Thời điểm 3 tháng sau đó tăng lên 75,69 ISQ và sự khác biệt có ý nghĩa thống kê (p=0,01). Kết luận: Lực vặn implant thuộc nhóm 30 – 35 Ncm chiếm đa số với 63%, chỉ số ISQ trung bình ghi nhận tại thời điểm cấy ghép là 74,41 ± 5,55. Sau 03 tháng chỉ số ISQ tăng lên 75,72 ± 5,34.
Mobile Phone Dependence among Junior High School Students in Public Schools in the Philippines
Authors: M. Ortiz Portia Mae , V. Tagayong Leah , C. Derasin Lloyd Matthew
Published: July 2023

The study focused on Mobile Phone Dependence among Junior High School Students in Public Schools in the Philippines. The study utilized a quantitative method and employed a descriptive research design. This study aims to describe mobile phone dependence among junior high students. The respondents of the study are the Grade 10 students of San Jose National High School in San Jose, Talibon, Bohol, and Philippines. A random sampling technique was applied in selecting the respondents. In this study, a standardized questionnaire by Mukhdoomiet.al (2020) was used to measure the mobile dependence of the respondents. Moreover, the finding revealed that students find it easy to utilize a mobile phone for academic purposes, which increases their perceived usefulness. Since we live in the 21st century, teaching and learning can be done digitally. It is recommended that Students should use mobile-friendly educational tools. Mobile-friendly instructional resources also enable interactive and self-guided learning, motivating students. Likewise, teachers must also inform students of the dangers of overusing mobile phones.
Hyperferritinemia and non-HFE hemochromatosis: differential diagnosis and workup
Authors: Lommaert E , Verlinden W , Duysburgh I , Holvoet T , Schouten J
Published: July 2023

Hyperferritinemia is a common reason for referral to a hepatogastroenterologist. The most frequent causes are not associated with iron overload (e.g. inflammatory diseases, alcohol abuse, metabolic syndrome, etc.). However, hyperferritinemia can also be caused by a genetic variant in one of the iron regulatory genes, called hereditary hemochromatosis, often but not always associated with iron overload. A variation in the human Hemostatic Iron Regulator protein (HFE) gene is the most common genotype, but many other variants have been described. In this paper we discuss two cases of rare hyperferritinemia associated disorders, ferroportin disease and hyperferritinemia-cataract syndrome. We also propose an algorithm for evaluating hyperferritinemia, facilitating a correct diagnosis and preventing potentially unnecessary examinations and therapeutic actions.
Irritable bowel syndrome-like symptoms before and after bariatric surgery and association with short-chain fermentable carbohydrates consumption: an observational prospective study
Authors: Van Ouytsel P , Piessevaux H , Szalai A , Loi P , Louis H
Published: July 2023

Background and aims: Irritable Bowel Syndrome (IBS)-like symptoms are frequent following bariatric surgery. This study aims to evaluate the frequency of IBS symptoms severity before and after bariatric surgery and their association with short-chain fermentable carbohydrates (FODMAPs) consumption.

Patients and methods: IBS symptoms severity in a cohort of obese patients was evaluated prospectively before, 6 and 12 months after bariatric surgery by validated questionnaires and tools (Irritable Bowel Syndrome Severity Scoring System (IBS SSS), Bristol Stool Scale (BSS), Quality of Life Short- Form-12 (SF-12), Hospital Anxiety and Depression scale (HAD)). FODMAPs consumption and its association with IBS symptom severity was evaluated by using a food frequency questionnaire focused on high-FODMAPs food consumption.

Results: Fifty-one patients were included (41 female; mean age 41 years (SD: 12)), 84% received a sleeve gastrectomy, and 16% a Roux-en-Y gastric bypass. Symptoms compatible with IBS were observed in 43% of patients before surgery, in 58% of patients at 6 months and 33% at 12 months (NS, p-value=0,197 and 0,414). In a multivariate model, a significant association was found between the IBS SSS score and lactose consumption at 6 months (β = + 58, 1; p = 0.03), and with polyols consumption at 12 months (β = + 112,6; p = 0.01).

Conclusions: Mild to moderate IBS symptoms are frequent in obese patients before bariatric surgery. A significant association between lactose and polyols consumption and IBS SSS score was observed after bariatric surgery, suggesting a potential link between the severity of IBS symptoms and some specific FODMAPs consumption.
ANALISIS MISKONSEPSI SISWA MTs MELALUI PEMBELAJARAN INKUIRI PADA MATERI SEGITIGA MENGGUNAKAN CERTAINTY OF RESPONSE INDEX (CRI)
Authors: Rohim Abdur
Published: July 2023

This research is motivated by the many misconceptions (misconceptions) experienced by class VII students in the triangle material and the absence of previous research that examines misconceptions at MTs Hidayatus Salam. The purpose of this study is to describe the misconceptions experienced by MTs students through inquiry learning on triangle material and the factors that cause misconceptions. This type of research is a qualitative descriptive research conducted at MTs Hidayatus Salam Lowayu with using 6 subjects who experienced most misconceptions. Data collected with give test misconception completed triangle with table Certainty of Response Index (CRI) and semi- structured interview. Results Study show that: 1 ) there are differences in students' misconceptions, in the category of classificational type misconceptions in solving the triangle problem students meet the indicators of classificational misconceptions, namely, students To do error in classify between get up triangle. In the category of theoretical misconceptions, students meet the indicators of theoretical misconceptions, namely, students make mistakes in defining the concept of a triangle. In the category of correlational misconceptions, students meet the indicators of correlational misconceptions, namely students make mistakes in connecting the formulas used with the problems in the questions. 2) the causes of misconceptions are the lack of student learning experience, the teacher does not emphasize the concept, the lack of understanding the prerequisite concept, the inability of students to connect between concepts, students' initial conceptions are wrong and the context of everyday language.
ANALISIS FAKTOR – FAKTOR YANG MEMPENGARUHI KEPUASAN KERJA KARYAWAN PT GMM BLORA
Authors: Renanda Enisa Olivia , Indiworo Hawik Ervina I , Setyorini Noni
Published: July 2023

This study aims to determine the effect of work-life balance variables, workload, and fatigue on job satisfaction of PT GMM Blora employees. The population studied was 100 employees. This study uses SPSS software with multiple regression tests as a hypothesis testing method. The results of the analysis and discussion show that the variables have a partial effect, namely: Work-life balance has a positive and significant effect on job satisfaction of PT GMM Blora employees. Workload has a positive and significant effect on job satisfaction of PT GMM Blora employees, and burnout has a positive and significant effect on job satisfaction of PT GMM Blora employees.
Abstrak
Penelitian ini bertujuan untuk mengetahui pengaruh  variabel work-life balance, workload, serta kelelahan  pada kepuasan kerja karyawan  PT GMM Blora. Populasi yang diteliti adalah 100 karyawan. Penelitian ini menggunakan software SPSS dengan uji regresi berganda sebagai metode pengujian hipotesis. Hasil analisis dan pembahasan menunjukkan variabel berpengaruh secara persial yaitu : Work-life balance  berpengaruh positive dan  signifikan pada kepuasan kerja karyawan  PT GMM Blora. Beban kerja  berpengaruh  positive serta signifikan pada kepuasan kerja karyawan PT GMM Blora dan burnout  berpengaruh  positive dan signifikan pada kepuasan kerja karyawan PT GMM Blora.
PENGARUH CITA RASA, LABEL HALAL, PENETAPAN HARGA DAN IKLAN TERHADAP KEPUTUSAN PEMBELIAN MIE SAMYANG PADA MAHASISWA FAKULTAS EKONOMI DAN BISNIS UNIVERSITAS YPPI REMBANG
Authors: Karina Emelinda Octavian  , Syaiko Rosyidi
Published: July 2023

The purpose of this study was to prove the effect of taste, halal labeling, pricing and advertising on purchasing decisions for Samyang Noodles for students of the Faculty of Economics and Business, YPPI University, Rembang. The research population was FEB UYR students who had purchased, consumed or seen Samyang Noodle advertisements. The sampling technique uses quota sampling with a sample of 100 respondents. The data analysis technique used multiple linear regression analysis with the SPSS 24 tool. The results of the study proved that the variables of taste and pricing partially had a significant positive effect on purchasing decisions for Samyang Noodles on FEB UYR students, while the halal label and advertising variables had a partial positive effect not significant effect on purchasing decisions of Samyang Noodles among FEB UYR students. The results of the determination test showed that the variable taste, halal label, pricing and advertising were only able to influence purchasing decisions by 44.7% while the remaining 55.3% were influenced by other variables outside of this study.

Abstrak

Tujuan dari penelitian ini adalah untuk membuktikan pengaruh cita rasa, label halal, penetapan harga dan iklan terhadap keputusan pembelian Mie Samyang pada mahasiswa Fakultas Ekonomi dan Bisnis Universitas YPPI Rembang. Populasi penelitian adalah mahasiswa FEB UYR yang pernah melakukan pembelian, mengkonsumsi atau melihat iklan Mie Samyang. Teknik pengambilan sampel dengan menggunakan quota sampling dengan sampel sebanyak 100 responden. Teknik analisis data menggunakan analisis regresi linier bergandan dengan alat bantu SPSS 24. Hasil penelitian membuktikan bahwa variabel cita rasa dan penetapan harga secara parsial berpengaruh positif signifikan terhadap keputusan pembelian Mie Samyang pada mahasiswa FEB UYR, sedangkan variabel label halal dan iklan secara parsial berpengaruh positif tidak signifikan terhadap keputusan pembelian Mie Samyang pada mahasiswa FEB UYR. Hasil uji determinasi menunjukkan bahwa variabel cita rasa, label halal, penetapan harga dan iklan hanya mampu mempengaruhi keputusan pembelian sebesar 44,7% sedangkan sisanya yaitu 55,3% dipengaruhi oleh variabel lain diluar penelitian ini.