bluuebunny/crossref_metadata_2025 huggingface dataset:
Effect of Enteral Versus Parenteral Nutrition on Outcome of Medical Patients Requiring Mechanical Ventilation
Authors: Altintas Neriman Defne , Aydin Kadriye , Türkoğlu Melda Aybar , Abbasoğlu Osman , Topeli Arzu
Published: April 2011

Background: Early enteral nutrition (EN) in patients receiving mechanical ventilation commonly has been advocated, based mainly on studies conducted in mixed populations of trauma and surgery patients. In this study, ventilator‐associated pneumonia rates and outcomes were compared in mechanically ventilated medical intensive care unit (ICU) patients receiving enteral versus parenteral nutrition. Methods: Patients fulfilling inclusion criteria between February 1, 2004, and January 31, 2006, were included. Patients were randomized to enteral or parenteral nutrition (PN) within 48 hours of intubation. Development of ventilator‐associated pneumonia, assessment as to whether day feeding goal was attained, duration of mechanical ventilation, ICU and hospital length of stay (LOS), and mortality rates were recorded. Results: Of 249 consecutive patients receiving mechanical ventilation, 71 patients were included. Thirty (42.3%) patients received EN, and 41 (57.7%) received PN. There was no difference between groups for age, sex, body mass index, and scores on the Acute Physiology and Chronic Health Evaluation II. Ventilator‐associated pneumonia rate, ICU and hospital LOS, and mortality rates were similar for both groups. In the parenterally fed group, duration of mechanical ventilation was longer (p = .023), but the feeding goal was attained earlier (p = .012). Conclusions: In mechanically ventilated patients in the medical ICU, ventilator‐associated pneumonia rates, ICU and hospital lengths of stay, and ICU and hospital mortality rates of patients receiving PN are not significantly different than those in patients receiving EN, and feeding goals can more effectively be attained by PN. Yet, duration of mechanical ventilation is slightly longer in patients receiving PN.
Outcome Evaluation of the Hands-On Parent Empowerment (HOPE) Program
Authors: Leung Cynthia , Tsang Sandra , Dean Suzanne
Published: April 2011

This study evaluated the effectiveness of the HOPE program. Participants included 120 Chinese new immigrant parents with preschool children in Hong Kong from 13 preschools which were randomized into intervention group (HOPE) and comparison group (6-session parent education program). Parent participants completed measures on child behavior, parenting stress, social support and self-efficacy before and after intervention. The children were assessed on the WPPSI-R and receptive vocabulary before and after parent intervention. Results indicated significant decrease in post-intervention child behavior problems and parenting stress and increase in social support in the intervention group, compared with the comparison group. Implications for service delivery for parents of preschool children were discussed.
Small-Intestinal Rhabdoid Gastrointestinal Stromal Tumor (GIST)
Authors: Hanson Joshua Anspach , Trent Jonathan C. , Yang Dan , Cooper Kumarasen
Published: April 2011

Rhabdoid features in gastrointestinal stromal tumors (GISTs) are rare. To the authors’ knowledge, only 51 cases have been reported. Most of these reports consist of case series in which the rhabdoid GISTs comprise a small proportion of the tumors studied. Information regarding site of origin and clinical behavior is sparse. Although the stomach is the only site of origin documented, most reports do not include this data. Malignancy has not been reported, though follow-up is inadequate in most cases to comment on tumor behavior. Exon 11 mutations comprise all previously described KIT mutations, the majority of which are deletions. The authors present the case of a malignant small-intestinal rhabdoid GIST that recurred twice following resection and treatment with tyrosine kinase inhibitors. The tumor harbored a KIT exon 11, 579-580 LY insertion that, to the authors’ knowledge, has not been previously reported. This case is the first rhabdoid GIST described in the small intestine and is the first to show documented evidence of malignancy.
What Accounts for Men’s Hostile Attitudes Toward Women? The Influence of Hegemonic Male Role Norms and Masculine Gender Role Stress
Authors: Gallagher Kathryn E. , Parrott Dominic J.
Published: April 2011

This study examined masculine gender role stress (MGRS) as a mediator of the relation between adherence to dimensions of a hegemonic masculinity and hostility toward women (HTW). Among a sample of 338 heterosexual men, results indicated that MGRS mediated the relation between adherence to the status and antifemininity norms, but not the toughness norm, and HTW. Adherence to the toughness norm maintained a positive association with HTW. These findings suggest that men’s HTW develops via multiple pathways that are associated with different norms of hegemonic masculinity. Implications for the prediction of men’s aggression against women are discussed.
Removing Barriers to APRN Practice in the State of Hawai’i
Authors: Mathews Barbara P. , Boland Mary G. , Kim Stanton Barbara
Published: April 2011

An informal coalition of nurses, educators, health care providers and policy makers recognizing that administrative rules for advanced practice registered nurse (APRN) practice limited consumer access to care in Hawai’i, developed an initiative to bring about legislative and regulatory change using the National Council of State Boards of Nursing APRN Scope of Nursing Practice and Standards Related to the APRN. The authors report on the process including challenges and keys to success toward the passage of Hawai’i Act 169 (2009). The authors also discuss key components of the legislation, which removed barriers to full scope of practice for APRNs. The potential for comprehensive reform was realized due to the actions of a broad coalition in support of increasing access to care for underserved and rural populations in Hawai’i.
Recruiting and Retaining a Diverse Workforce in Nursing: From Evidence to Best Practices to Policy
Authors: Gilliss Catherine L. , Powell Dorothy L. , Carter Brigit
Published: April 2011

Health policy makers, providers, clinicians, and social scientists are among those who have identified racial and ethnic diversification of the health care workforce as one strategy for solving the seemingly intractable problem of health disparities in the U.S. population. But evidence supporting the impact of such diversification on narrowing health disparities is lacking, thus making it unclear if the push for workforce diversification is empirically or politically driven. Moreover, data are largely derived from the study of physicians, making it difficult to generalize findings to nursing and other health professions. This article reviews the evidence that supports the impact of a diverse workforce on patient outcomes and delivery services. Assuming a positive social value in the absence of the data, the authors review the approaches that have been successful in diversifying the nursing workforce. The authors conclude with recommendations for research and policies, including best practices, for enhancing recruitment and retention of a diverse nursing workforce.
What Shapes the News around the World? How Journalists in Eighteen Countries Perceive Influences on Their Work
Authors: Hanitzsch Thomas , Mellado Claudia
Published: April 2011

This article compares the perceived importance of influences on news work across 18 societies. Evidence is based on journalists’ survey responses to a six-dimensional scale, covering political, economic, organizational, professional, and procedural influences as well as influences from reference groups. The results confirm the expectation that political and economic factors are clearly the most important denominators of cross-national differences in the journalists’ perceptions of influences. Furthermore, perceived political influences are clearly related to objective indicators of political freedom and ownership structures across the investigated countries. Economic influences seem to have a stronger impact in private and state-owned media than in public newsrooms, but they are not related to a country’s economic freedom. With respect to organizational, professional, and procedural influences as well as the impact of reference groups, the differences between the countries turned out to be much smaller.
The Myeloproliferative Neoplasm Symptom Assessment Form (MPN-SAF): International Prospective Validation and Reliability Trial in 402 patients
Authors: Scherber Robyn , Dueck Amylou C. , Johansson Peter , Barbui Tiziano , Barosi Giovanni , Vannucchi Alessandro M. , Passamonti Francesco , Andreasson Bjorn , Ferarri Maria L. , Rambaldi Alessandro , Samuelsson Jan , Birgegard Gunnar , Tefferi Ayalew , Harrison Claire N. , Radia Deepti , Mesa Ruben A.
Published: May 2011

Symptomatic burden in myeloproliferative neoplasms is present in most patients and compromises quality of life. We sought to validate a broadly applicable 18-item instrument (Myeloproliferative Neoplasm Symptom Assessment Form [MPN-SAF], coadministered with the Brief Fatigue Inventory) to assess symptoms of myelofibrosis, essential thrombocythemia, and polycythemia vera among prospective cohorts in the United States, Sweden, and Italy. A total of 402 MPN-SAF surveys were administered (English [25%], Italian [46%], and Swedish [28%]) in 161 patients with essential thrombocythemia, 145 patients with polycythemia vera, and 96 patients with myelofibrosis. Responses among the 3 administered languages showed great consistency after controlling for MPN subtype. Strong correlations existed between individual items and key symptomatic elements represented on both the MPN-SAF and the European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire-C30. Enrolling physicians' blinded opinion of patient symptoms (6 symptoms assessed) were highly correlated with corresponding patients' responses. Serial administration of the English MPN-SAF among 53 patients showed that most MPN-SAF items are well correlated (r > 0.5, P < .001) and highly reproducible (intraclass correlation coefficient > 0.7). The MPN-SAF is a comprehensive and reliable instrument that is available in multiple languages to evaluate symptoms associated with all types of MPNs in clinical trials globally.
Prognostic significance of immunohistochemical biomarkers in diffuse large B-cell lymphoma: a study from the Lunenburg Lymphoma Biomarker Consortium
Authors: Salles Gilles , de Jong Daphne , Xie Wanling , Rosenwald Andreas , Chhanabhai Mukesh , Gaulard Philippe , Klapper Wolfram , Calaminici Maria , Sander Birgitta , Thorns Christoph , Campo Elias , Molina Thierry , Lee Abigail , Pfreundschuh Michael , Horning Sandra , Lister Andrew , Sehn Laurie H. , Raemaekers John , Hagenbeek Anton , Gascoyne Randy D. , Weller Edie
Published: May 2011

The Lunenburg Lymphoma Biomarker Consortium (LLBC) evaluated the prognostic value of IHC biomarkers in a large series of patients with diffuse large B-cell lymphoma (DLBCL). Clinical data and tumor samples were retrieved from 12 studies from Europe and North America, with patients treated before or after the rituximab era. Using tissue microarrays from 1514 patients, IHC for BCL2, BCL6, CD5, CD10, MUM1, Ki67, and HLA-DR was performed and scored according to previously validated protocols. Optimal cut points predicting overall survival of patients treated in the rituximab era could only be determined for CD5 (P = .003) and Ki67 (P = .02), whereas such cut points for BCL2, BCL6, HLA-DR, and MUM1 could only be defined in patients not receiving rituximab. A prognostic model for patients treated in the rituximab era identified 4 risk groups using BCL2, Ki67, and International Prognostic Index (IPI) with improved discrimination of low-risk patients. Newly recognized correlations between specific biomarkers and IPI highlight the importance of carefully controlling for clinical and biologic factors in prognostic models. These data demonstrate that the IPI remains the best available index in patients with DLBCL treated with rituximab and chemotherapy.
Involvement of mast cells in monocrotaline-induced pulmonary hypertension in rats
Authors: Dahal Bhola K , Kosanovic Djuro , Kaulen Christina , Cornitescu Teodora , Savai Rajkumar , Hoffmann Julia , Reiss Irwin , Ghofrani Hossein A , Weissmann Norbert , Kuebler Wolfgang M , Seeger Werner , Grimminger Friedrich , Schermuly Ralph T
Published: May 2011

Background

Mast cells (MCs) are implicated in inflammation and tissue remodeling. Accumulation of lung MCs is described in pulmonary hypertension (PH); however, whether MC degranulation and c-kit, a tyrosine kinase receptor critically involved in MC biology, contribute to the pathogenesis and progression of PH has not been fully explored.

Methods

Pulmonary MCs of idiopathic pulmonary arterial hypertension (IPAH) patients and monocrotaline-injected rats (MCT-rats) were examined by histochemistry and morphometry. Effects of the specific c-kit inhibitor PLX and MC stabilizer cromolyn sodium salt (CSS) were investigated in MCT-rats both by the preventive and therapeutic approaches. Hemodynamic and right ventricular hypertrophy measurements, pulmonary vascular morphometry and analysis of pulmonary MC localization/counts/activation were performed in animal model studies.

Results

There was a prevalence of pulmonary MCs in IPAH patients and MCT-rats as compared to the donors and healthy rats, respectively. Notably, the perivascular MCs were increased and a majority of them were degranulated in lungs of IPAH patients and MCT-rats (p < 0.05 versus donor and control, respectively). In MCT-rats, the pharmacological inhibitions of MC degranulation and c-kit with CSS and PLX, respectively by a preventive approach (treatment from day 1 to 21 of MCT-injection) significantly attenuated right ventricular systolic pressure (RVSP) and right ventricular hypertrophy (RVH). Moreover, vascular remodeling, as evident from the significantly decreased muscularization and medial wall thickness of distal pulmonary vessels, was improved. However, treatments with CSS and PLX by a therapeutic approach (from day 21 to 35 of MCT-injection) neither improved hemodynamics and RVH nor vascular remodeling.

Conclusions

The accumulation and activation of perivascular MCs in the lungs are the histopathological features present in clinical (IPAH patients) and experimental (MCT-rats) PH. Moreover, the accumulation and activation of MCs in the lungs contribute to the development of PH in MCT-rats. Our findings reveal an important pathophysiological insight into the role of MCs in the pathogenesis of PH in MCT- rats.
SNPPicker: High quality tag SNP selection across multiple populations
Authors: Sicotte Hugues , Rider David N , Poland Gregory A , Dhiman Neelam , Kocher Jean-Pierre A
Published: May 2011

Background

Linkage Disequilibrium (LD) bin-tagging algorithms identify a reduced set of tag SNPs that can capture the genetic variation in a population without genotyping every single SNP. However, existing tag SNP selection algorithms for designing custom genotyping panels do not take into account all platform dependent factors affecting the likelihood of a tag SNP to be successfully genotyped and many of the constraints that can be imposed by the user.

Results

SNPPicker optimizes the selection of tag SNPs from common bin-tagging programs to design custom genotyping panels. The application uses a multi-step search strategy in combination with a statistical model to maximize the genotyping success of the selected tag SNPs. User preference toward functional SNPs can also be taken into account as secondary criteria. SNPPicker can also optimize tag SNP selection for a panel tagging multiple populations. SNPPicker can optimize custom genotyping panels including all the assay-specific constraints of Illumina's GoldenGate and Infinium assays.

Conclusions

A new application has been developed to maximize the success of custom multi-population genotyping panels. SNPPicker also takes into account user constraints including options for controlling runtime. Perl Scripts, Java source code and executables are available under an open source license for download at http://mayoresearch.mayo.edu/mayo/research/biostat/software.cfm
Adaptive phenotypic plasticity in the Midas cichlid fish pharyngeal jaw and its relevance in adaptive radiation
Authors: Muschick Moritz , Barluenga Marta , Salzburger Walter , Meyer Axel
Published: April 2011

Background

Phenotypic evolution and its role in the diversification of organisms is a central topic in evolutionary biology. A neglected factor during the modern evolutionary synthesis, adaptive phenotypic plasticity, more recently attracted the attention of many evolutionary biologists and is now recognized as an important ingredient in both population persistence and diversification. The traits and directions in which an ancestral source population displays phenotypic plasticity might partly determine the trajectories in morphospace, which are accessible for an adaptive radiation, starting from the colonization of a novel environment. In the case of repeated colonizations of similar environments from the same source population this "flexible stem" hypothesis predicts similar phenotypes to arise in repeated subsequent radiations. The Midas Cichlid (Amphilophusspp.) in Nicaragua has radiated in parallel in several crater-lakes seeded by populations originating from the Nicaraguan Great Lakes. Here, we tested phenotypic plasticity in the pharyngeal jaw of Midas Cichlids. The pharyngeal jaw apparatus of cichlids, a second set of jaws functionally decoupled from the oral ones, is known to mediate ecological specialization and often differs strongly between sister-species.

Results

We performed a common garden experiment raising three groups of Midas cichlids on food differing in hardness and calcium content. Analyzing the lower pharyngeal jaw-bones we find significant differences between diet groups qualitatively resembling the differences found between specialized species. Observed differences in pharyngeal jaw expression between groups were attributable to the diet's mechanical resistance, whereas surplus calcium in the diet was not found to be of importance.

Conclusions

The pharyngeal jaw apparatus of Midas Cichlids can be expressed plastically if stimulated mechanically during feeding. Since this trait is commonly differentiated - among other traits - between Midas Cichlid species, its plasticity might be an important factor in Midas Cichlid speciation. The prevalence of pharyngeal jaw differentiation across the Cichlidae further suggests that adaptive phenotypic plasticity in this trait could play an important role in cichlid speciation in general. We discuss several possibilities how the adaptive radiation of Midas Cichlids might have been influenced in this respect.
Clarifying mammalian RISC assembly in vitro
Authors: Tan Grace S , Garchow Barry G , Liu Xuhang , Metzler David , Kiriakidou Marianthi
Published: April 2011

Background

Argonaute, the core component of the RNA induced silencing complex (RISC), binds to mature miRNAs and regulates gene expression at transcriptional or post-transcriptional level. We recently reported that Argonaute 2 (Ago2) also assembles into complexes with miRNA precursors (pre-miRNAs). These Ago2:pre-miRNA complexes are catalytically active in vitro and constitute non-canonical RISCs.

Results

The use of pre-miRNAs as guides by Ago2 bypasses Dicer activity and complicates in vitro RISC reconstitution. In this work, we characterized Ago2:pre-miRNA complexes and identified RNAs that are targeted by miRNAs but not their corresponding pre-miRNAs. Using these target RNAs we were able to recapitulate in vitro pre-miRNA processing and canonical RISC loading, and define the minimal factors required for these processes.

Conclusions

Our results indicate that Ago2 and Dicer are sufficient for processing and loading of miRNAs into RISC. Furthermore, our studies suggest that Ago2 binds primarily to the 5'- and alternatively, to the 3'-end of select pre-miRNAs.
A Parametric Study Delineating Irreversible Electroporation from Thermal Damage Based on a Minimally Invasive Intracranial Procedure
Authors: Garcia Paulo A , Rossmeisl John H , Neal Robert E , Ellis Thomas L , Davalos Rafael V
Published: April 2011

Background

Irreversible electroporation (IRE) is a new minimally invasive technique to kill undesirable tissue in a non-thermal manner. In order to maximize the benefits from an IRE procedure, the pulse parameters and electrode configuration must be optimized to achieve complete coverage of the targeted tissue while preventing thermal damage due to excessive Joule heating.

Methods

We developed numerical simulations of typical protocols based on a previously published computed tomographic (CT) guided in vivo procedure. These models were adapted to assess the effects of temperature, electroporation, pulse duration, and repetition rate on the volumes of tissue undergoing IRE alone or in superposition with thermal damage.

Results

Nine different combinations of voltage and pulse frequency were investigated, five of which resulted in IRE alone while four produced IRE in superposition with thermal damage.

Conclusions

The parametric study evaluated the influence of pulse frequency and applied voltage on treatment volumes, and refined a proposed method to delineate IRE from thermal damage. We confirm that determining an IRE treatment protocol requires incorporating all the physical effects of electroporation, and that these effects may have significant implications in treatment planning and outcome assessment. The goal of the manuscript is to provide the reader with the numerical methods to assess multiple-pulse electroporation treatment protocols in order to isolate IRE from thermal damage and capitalize on the benefits of a non-thermal mode of tissue ablation.
Role of adhesion molecules and inflammation in Venezuelan equine encephalitis virus infected mouse brain
Authors: Sharma Anuj , Bhomia Manish , Honnold Shelley P , Maheshwari Radha K
Published: April 2011

Background

Neuroinvasion of Venezuelan equine encephalitis virus (VEEV) and subsequent initiation of inflammation in the brain plays a crucial role in the outcome of VEEV infection in mice. Adhesion molecules expressed on microvascular endothelial cells in the brain have been implicated in the modulation of the blood brain barrier (BBB) and inflammation in brain but their role in VEEV pathogenesis is not very well understood. In this study, we evaluated the expression of extracellular matrix and adhesion molecules genes in the brain of VEEV infected mice.

Findings

Several cell to cell adhesion molecules and extracellular matrix protein genes such as ICAM-1, VCAM-1, CD44, Cadherins, integrins, MMPs and Timp1 were differentially regulated post-VEEV infection. ICAM-1 knock-out (IKO) mice infected with VEEV had markedly reduced inflammation in the brain and demonstrated a delay in the onset of clinical symptoms of disease. A differential regulation of inflammatory genes was observed in the IKO mice brain compared to their WT counterparts.

Conclusions

These results improve our present understanding of VEEV induced inflammation in mouse brain.
Impact of chromium histidinate on high fat diet induced obesity in rats
Authors: Tuzcu Mehmet , Sahin Nurhan , Orhan Cemal , Agca Can Ali , Akdemir Fatih , Tuzcu Zeynep , Komorowski James , Sahin Kazim
Published: May 2011

Background

Chromium (Cr) is an essential trace element that has garnered interest for use as a weight loss aid, but its molecular mechanism in obesity is not clear. In this study, an attempt has been made to investigate the effects of chromium histidinate (CrHis) on glucose transporter-2 (GLUT-2), nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase-1 (HO-1), nuclear factor-kappa B (NF-κB p65) and the oxidative stress marker 4-hydroxynonenal adducts (HNE) expressions in liver of rats fed high fat diet (HFD).

Methods

Male Wistar rats (n = 40, 8 wk-old) were divided into four groups. Group I was fed a standard diet (12% of calories as fat); Group II was fed a standard diet and supplemented with 110 μg CrHis/kg BW/d; Group III was fed a HFD (40% of calories as fat); Group IV was fed HFD and supplemented with 110 μg CrHis/kg BW/d.

Results

Rats fed HFD possessed greater serum insulin (40 vs.33 pmol/L) and glucose (158 vs. 143 mg/dL) concentration and less liver Cr (44 vs.82 μg/g) concentration than rats fed the control diet. However, rats supplemented with CrHis had greater liver Cr and serum insulin and lower glucose concentration in rats fed HFD (P < 0.05). The hepatic nuclear factor-kappa B (NF-κB p65) and HNE were increased in high fat group compared to control group, but reduced by the CrHis administration (P < 0.05). The levels of hepatic Nrf2 and HO-1 were increased by supplementation of CrHis (P < 0.05).

Conclusion

These findings demonstrate that supplementation of CrHis is protective against obesity, at least in part, through Nrf2-mediated induction of HO-1 in rats fed high fat diet.
Prevalence of SOS-mediated control of integron integrase expression as an adaptive trait of chromosomal and mobile integrons
Authors: Cambray Guillaume , Sanchez-Alberola Neus , Campoy Susana , Guerin Émilie , Da Re Sandra , González-Zorn Bruno , Ploy Marie-Cécile , Barbé Jordi , Mazel Didier , Erill Ivan
Published: April 2011

Background

Integrons are found in hundreds of environmental bacterial species, but are mainly known as the agents responsible for the capture and spread of antibiotic-resistance determinants between Gram-negative pathogens. The SOS response is a regulatory network under control of the repressor protein LexA targeted at addressing DNA damage, thus promoting genetic variation in times of stress. We recently reported a direct link between the SOS response and the expression of integron integrases in Vibrio cholerae and a plasmid-borne class 1 mobile integron. SOS regulation enhances cassette swapping and capture in stressful conditions, while freezing the integron in steady environments. We conducted a systematic study of available integron integrase promoter sequences to analyze the extent of this relationship across the Bacteria domain.

Results

Our results showed that LexA controls the expression of a large fraction of integron integrases by binding to Escherichia coli-like LexA binding sites. In addition, the results provide experimental validation of LexA control of the integrase gene for another Vibrio chromosomal integron and for a multiresistance plasmid harboring two integrons. There was a significant correlation between lack of LexA control and predicted inactivation of integrase genes, even though experimental evidence also indicates that LexA regulation may be lost to enhance expression of integron cassettes.

Conclusions

Ancestral-state reconstruction on an integron integrase phylogeny led us to conclude that the ancestral integron was already regulated by LexA. The data also indicated that SOS regulation has been actively preserved in mobile integrons and large chromosomal integrons, suggesting that unregulated integrase activity is selected against. Nonetheless, additional adaptations have probably arisen to cope with unregulated integrase activity. Identifying them may be fundamental in deciphering the uneven distribution of integrons in the Bacteria domain.
Differences between psychopathy and other personality disorders: evidence from neuroimaging
Authors: Sarkar Sagari , Clark Ben S. , Deeley Quinton
Published: April 2011

ICD-10 and DSM-IV-TR diagnostic guidelines do not list psychopathy as a distinct psychiatric entity. However, there are significant overlaps between psychopathy and DSM-IV-TR Cluster B personality disorders. Neuroimaging studies implicate deficits in structure and function of frontal and limbic regions in this group of personality disorders, while highlighting both distinctions and overlaps between syndromes. Here, these data are reviewed and implications for diagnosis and clinical practice are discussed.
Association of Comorbidities With Overall Survival in Myelodysplastic Syndrome: Development of a Prognostic Model
Authors: Naqvi Kiran , Garcia-Manero Guillermo , Sardesai Sagar , Oh Jeong , Vigil Carlos E. , Pierce Sherry , Lei Xiudong , Shan Jianqin , Kantarjian Hagop M. , Suarez-Almazor Maria E.
Published: May 2011

Purpose

Patients with cancer often experience comorbidities that may affect their prognosis and outcome. The objective of this study was to determine the effect of comorbidities on the survival of patients with myelodysplastic syndrome (MDS).

Patients and Methods

We conducted a retrospective cohort study of 600 consecutive patients with MDS who presented to MD Anderson Cancer Center from January 2002 to December 2004. The Adult Comorbidity Evaluation-27 (ACE-27) scale was used to assess comorbidities. Data on demographics, International Prognostic Scoring System (IPSS), treatment, and outcome (leukemic transformation and survival) were collected. Kaplan-Meier methods and Cox regression were used to assess survival. A prognostic model incorporating baseline comorbidities with age and IPSS was developed to predict survival.

Results

Overall median survival was 18.6 months. According to the ACE-27 categories, median survival was 31.8, 16.8, 15.2, and 9.7 months for those with none, mild, moderate, and severe comorbidities, respectively (P < .001). Adjusted hazard ratios were 1.3, 1.6, and 2.3 for mild, moderate, and severe comorbidities, respectively, compared with no comorbidities (P < .001). A final pognostic model including age, IPSS, and comorbidity score predicted median survival of 43.0, 23.0, and 9.0 months for lower-, intermediate-, and high-risk groups, respectively (P < .001).

Conclusion

Comorbidities have a significant impact on the survival of patients with MDS. Patients with severe comorbidity had a 50% decrease in survival, independent of age and IPSS risk group. A comprehensive assessment of the severity of comorbidities helps predict survival in patients with MDS.
Progression From High-Grade Prostatic Intraepithelial Neoplasia to Cancer: A Randomized Trial of Combination Vitamin-E, Soy, and Selenium
Authors: Fleshner Neil E. , Kapusta Linda , Donnelly Bryan , Tanguay Simon , Chin Joseph , Hersey Karen , Farley Anne , Jansz Ken , Siemens D. Robert , Trpkov Kiril , Lacombe Louis , Gleave Martin , Tu Dongsheng , Parulekar Wendy R.
Published: May 2011

Purpose

High-grade prostatic intraepithelial neoplasia (HGPIN) is a putative precursor of invasive prostate cancer (PCa). Preclinical evidence suggests vitamin E, selenium, and soy protein may prevent progression of HGPIN to PCa. This hypothesis was tested in a randomized phase III double-blind study of daily soy (40 g), vitamin E (800 U), and selenium (200 μg) versus placebo.

Patients and Methods

Three hundred three men in 12 Canadian centers were analyzed. The main eligibility criterion was confirmed HGPIN in at least one of two biopsies within 18 months of random assignment. Treatment was administered daily for 3 years. Follow-up prostate biopsies occurred at 6, 12, 24, and 36 months postrandomization. The primary end point was time to development of invasive PCa. Kaplan-Meier plots and log-rank tests were used to compare two treatment groups for this end point.

Results

For all patients, the median age was 62.8 years. The median baseline prostate-specific antigen (PSA; n = 302) was 5.41 ug/L; total testosterone (n = 291) was 13.4 nmol/L. Invasive PCa developed among 26.4% of patients. The hazard ratio for the nutritional supplement to prevent PCa was 1.03 (95% CI, 0.67 to 1.60; P = .88). Gleason score distribution was similar in both groups with 83.5% of cancers graded Gleason sum of 6. Baseline age, weight, PSA, and testosterone did not predict for development of PCa. The supplement was well tolerated with flatulence reported more frequently (27% v 17%) among men receiving micronutrients.

Conclusion

This trial does not support the hypothesis that combination vitamin E, selenium, and soy prevents progression from HGPIN to PCa.
Phase II Trial of Bevacizumab in Recurrent or Persistent Endometrial Cancer: A Gynecologic Oncology Group Study
Authors: Aghajanian Carol , Sill Michael W. , Darcy Kathleen M. , Greer Benjamin , McMeekin D. Scott , Rose Peter G. , Rotmensch Jacob , Barnes Mack N. , Hanjani Parviz , Leslie Kimberly K.
Published: May 2011

Purpose

Bevacizumab, a recombinant humanized monoclonal antibody against vascular endothelial growth factor-A (VEGF-A), has clinical activity in multiple tumor types. We conducted a phase II trial to assess the activity and tolerability of single-agent bevacizumab in recurrent or persistent endometrial cancer (EMC).

Patients and Methods

Eligible patients had persistent or recurrent EMC after receiving one to two prior cytotoxic regimens, measurable disease, and Gynecologic Oncology Group performance status of ≤ 2. Treatment consisted of bevacizumab 15 mg/kg intravenously every 3 weeks until disease progression or prohibitive toxicity. VEGF-A was assessed by immunohistochemistry in archival tumor and by enzyme-linked immunosorbent assay in pretreatment plasma. Primary end points were progression-free survival (PFS) at 6 months and overall response rate.

Results

Fifty-six patients were enrolled. Fifty-two patients were eligible and evaluable. Median age was 62 years, and prior treatment consisted of one or two regimens in 33 (63.5%) and 19 (36.5%) patients, respectively. Twenty-nine patients (55.8%) received prior radiation. Adverse events were consistent with those expected with bevacizumab treatment. No GI perforations or fistulae were seen. Seven patients (13.5%) experienced clinical responses (one complete response and six partial responses; median response duration, 6.0 months), and 21 patients (40.4%) survived progression free for at least 6 months. Median PFS and overall survival times were 4.2 and 10.5 months, respectively. Suggested associations were observed between high VEGF-A and adjusted hazard of death or tumor response when evaluated in tumor/plasma or plasma, respectively.

Conclusion

Bevacizumab is well tolerated and active based on PFS at 6 months in recurrent or persistent EMC and warrants further investigation.
Efficient Risk Estimation via Nested Sequential Simulation
Authors: Broadie Mark , Du Yiping , Moallemi Ciamac C.
Published: April 2011

We analyze the computational problem of estimating financial risk in a nested simulation. In this approach, an outer simulation is used to generate financial scenarios, and an inner simulation is used to estimate future portfolio values in each scenario. We focus on one risk measure, the probability of a large loss, and we propose a new algorithm to estimate this risk. Our algorithm sequentially allocates computational effort in the inner simulation based on marginal changes in the risk estimator in each scenario. Theoretical results are given to show that the risk estimator has a faster convergence order compared to the conventional uniform inner sampling approach. Numerical results consistent with the theory are presented.

This paper was accepted by Gérard Cachon, stochastic models and simulation.
The Impact of Demand Aggregation Through Delayed Component Allocation in an Assemble-to-Order System
Authors: Bernstein Fernando , DeCroix Gregory A. , Wang Yulan
Published: April 2011

We consider an assemble-to-order system in which multiple products are assembled from a common component and a set of product-dedicated components. Component capacities are chosen prior to a finite-horizon selling season, and the common component is allocated to the products based on observed demands. We propose a collection of allocation mechanisms involving varying degrees of demand aggregation, ranging from a scheme under which all demands are observed prior to making the allocation decision to allocations made for each arriving demand. In this context, we explore the impact of the allocation scheme on sales, profits, and capacity decisions, including the degree of capacity imbalance. We find that the benefit from increased demand aggregation is closely linked to the degree of capacity imbalance: profit gains from delayed allocation tend to be higher in systems in which the optimal capacity portfolio is highly unbalanced when the allocation decision is made after observing all demands. We develop insights into what detailed system parameters lead to the largest gains from demand aggregation and also explore the trade-offs associated with the choice of an allocation scheme when customers exhibit impatience if the allocation scheme forces them to wait to be served.

This paper was accepted by Ananth Iyer, operations and supply chain management.
“I've Got a Theory Paper—Do You?”: Conceptual, Empirical, and Theoretical Contributions to Knowledge in the Organizational Sciences
Authors: Shapira Zur
Published: April 2011

Is “the field of management's devotion to theory too much of a good thing?” [Hambrick, D. C. 2007. The field of management's devotion to theory: Too much of a good thing? Acad. Management J. 50(6) 1346–1352]. In his paper, Hambrick criticizes the practice employed by many journals in the management field that requires that papers submitted for publication make a strong theoretical contribution. I argue that part of the problem is caused by the misunderstanding and misuse of the term “theory.” To clarify the status of theory, I review three modes of research formulation in the organizational sciences: theories, models, and conceptual frameworks. Language plays an important role in scientific research. I therefore discuss two research languages that are used in research in management that appear to be the farthest apart: mathematics, which is the language of precision; and narratives, which is the language that provides rich data. I provide a discussion of the use of mathematics in theory development and the use of narratives in research development. The two languages and three modes of research formulation are needed for contribution to knowledge, which should be the main goal of research in organization science.
Sensemaking Under Pressure: The Influence of Professional Roles and Social Accountability on the Creation of Sense
Authors: Cornelissen Joep P.
Published: April 2011

In this paper, I elaborate a theoretical model of how individuals come to make or create sense through their language while being accountable to others. Using accounts of corporate communication professionals who made sense of anomalous circumstances, I analyze how they used metaphorical words and expressions to organize their accounts and to negotiate between their own individual commitments and perceived social expectations. Based on the analysis, I induce that professionals (a) use individual metaphors to align themselves with the expectations of others and to mark particular roles for themselves that strictly meet those expectations (“strategic shifting”) when they perceive the social approval motive as strong; (b) engage in the extended use of a single metaphor to compress a situation into a frame that mediates between individual convictions and others' expectations (“framing”) when they know the views of others but are also strongly motivated to think through a circumstance as part of their professional role or previous commitments; and (c) systematically use a combination of metaphors that are blended and elaborated into a plausible narrative that attributes responsibility and prescribes a course of action (“narration”) when they are in a position (as part of their role) to define a circumstance, are unconstrained by past experiences, and do not directly know the views of others. This model integrates findings from prior research and combines the influence of role-related commitments and social accountability pressures on sensemaking.
Setting Your Own Standards: Internal Corporate Governance Codes as a Response to Institutional Pressure
Authors: Okhmatovskiy Ilya , David Robert J.
Published: April 2011

This paper is concerned with organizational response to institutional pressure. We argue that when faced with externally imposed standards, organizations can sometimes respond by developing alternative standards for the same practices. This “substitution response” can shift the attention of stakeholders away from noncompliance with the original standards to adherence to the alternative standards. Empirically, we examine organizational response to the introduction of a government-sponsored but nonmandatory corporate governance code. Unable to comply with all of the requirements of this very specific and demanding code, many firms responded by developing their own internal corporate governance codes. We predict and show that adoption of these internal codes is driven by the visibility of a firm's corporate governance practices and by mimetic forces. We also find that internal governance codes differ in their degree of ceremoniality and that ceremoniality is inversely related to organizational dependence on stakeholders who value good corporate governance. These findings help us to understand when organizational responses to institutional pressure take a ceremonial as opposed to substantive form.
Status Differences in the Cognitive Activation of Social Networks
Authors: Smith Edward Bishop , Menon Tanya , Thompson Leigh
Published: April 2011

We develop a dynamic cognitive model of network activation and show that people at different status levels spontaneously activate, or call to mind, different subsections of their networks when faced with job threat. Using a multimethod approach (General Social Survey data and a laboratory experiment), we find that, under conditions of job threat, people with low status exhibit a winnowing response (i.e., activating smaller and tighter subsections of their networks), whereas people with high status exhibit a widening response (i.e., activating larger and less constrained subsections of their networks). We integrate traditional network theories with cognitive psychology, suggesting that cognitively activating social networks is a precondition to mobilizing them. One implication is that narrowing the network in response to threat might reduce low-status group members' access to new information, harming their chances of finding subsequent employment and exacerbating social inequality.
PERSPECTIVE—Collective Intelligence in the Organization of Science
Authors: Woolley Anita Williams , Fuchs Erica
Published: April 2011

Whereas some suggest that consensus is the desirable end goal in fields of science, this paper suggests that the existing literature on collective intelligence offers key alternative insights into the evolution of knowledge in scientific communities. Drawing on the papers in this special issue, we find that the papers fall across a spectrum of convergent, divergent, and reflective activities. In addition, we find there to be a set of ongoing theoretical tensions common across the papers. We suggest that this diversity of activities and ongoing theoretical tensions—both signs of collective intelligence—may be a far more appropriate measure than consensus of the health of a scientific community.
Solvent-free reactions of alkynes in ball mills: It is definitely more than mixing
Authors: Stolle Achim , Ondruschka Bernd
Published: April 2011

This contribution presents two solvent-free reactions of terminal alkynes in ball mills: Pd-catalyzed Sonogashira cross-coupling and Cu-catalyzed homo-coupling (Glaser reaction). The results are compared to other solvent-free reaction protocols, which have been published up to date for those types of reactions. Reactions are assessed on the basis of reaction variables like type of catalyst and base or reaction time. Furthermore, performance-based parameters (yield, selectivity, turnover number, TON, and turnover frequency, TOF) are considered and evaluated. Findings from ball-milling experiments indicate that those processes are comparable to the energy entry by microwave irradiation with respect to reaction time and TOF.
Investigating the asymmetry of English sibilant assimilation: Acoustic and EPG data
Authors: Pouplier Marianne , Hoole Philip , Scobbie James M.
Published: May 2011

We present tongue-palate contact (EPG) and acoustic data on English sibilant assimilation, with a particular focus on the asymmetry arising from the order of the sibilants. It is generally known that /s#ʃ/ sequences may display varying degrees of regressive assimilation in fluent speech, yet for /ʃ#s/ it is widely assumed that no assimilation takes place, although the empirical content of this assumption has rarely been investigated nor a clear theoretical explanation proposed. We systematically compare the two sibilant orders in word-boundary clusters. Our data show that /s#ʃ/ sequences assimilate frequently and this assimilation is strictly regressive. The assimilated sequence may be indistinguishable from a homorganic control sequence by our measures, or it can be characterized by measurement values intermediate to those typical for /ʃ/ or /s/. /ʃ#s/ sequences may also show regressive assimilation, albeit less frequently and to a lesser degree. Assimilated /ʃ#s/ sequences are always distinguishable from /s#s/ sequences. In a few cases, we identify progressive assimilation for /ʃ#s/. We discuss how to account for the differences in degree of assimilation, and we propose that the order asymmetry may arise from the different articulatory control structures employed for the two sibilants in conjunction with phonotactic probability effects.
Emergence and present status of Lu-177 in targeted radiotherapy: the Indian scenario
Authors: Banerjee Sharmila , Das Tapas , Chakraborty S. , Venkatesh Meera
Published: May 2011

177Lu is presently considered to be a potential radionuclide for the development of agents for radionuclide therapy owing to its favorable nuclear decay characteristics [T
1/2 = 6.65 d, E

β(max) = 0.497 MeV, E

γ
= 113 KeV (6.4%) and 208 KeV (11%)]. While the long half-life of this promising radioisotope offers distinct logistic advantage, particularly, in countries having limited reactor facilities, the feasibility of its large-scale production with adequate specific activity and excellent radionuclidic purity in medium flux research reactors constitute yet another desirable feature. Extensive studies have been carried out to optimize the production of this isotope, with high specific activity and radionuclidic purity by the (n,γ) route using the highest available flux and the optimum irradiation time. The gradual evolution of clin ical grade 177LuCl3 as a new radiochemical, ready for commercial deployment by Radiopharmaceuticals Division, Bhabha Atomic Research Centre, to nuclear medicine centers all over India was accomplished in 2010 in a stepwise manner with the commencement of the production of high specific activity 177Lu from enriched target in 2001. Research on 177Lu has demonstrated its immense potential in radiotherapeutic applications, a direct outcome of which has resulted in indigenous development of two agents viz.
177Lu-EDTMP and 177Lu-DOTA-TATE presently being evaluated in human patients for palliative care of bone pain due to skeletal metastases and treatment of malignancies of neuroendocrine origin, respectively. Using locally produced 177Lu, the radiolabeling of a plethora of other molecules with potential applicability in radiation synovectomy and targeted therapy of malignant tumors have been successfully demonstrated. A few of these agent such as a novel 177Lu-labeled porphyrin has shown considerable promise in initial studies and is presently evaluated. In the present article, our research efforts toward standardization of production methodology of 177Lu in high specific activity and its utilization in the devel opment of agents for targeted radiotherapy are being reported.
The Relationship between India and Indonesia
Authors: Brewster David
Published: May 2011

This article examines the evolution of relations between India and Indonesia. It argues that there are grounds to believe that this relationship may develop into a broadbased security partnership over time. Whether this occurs sooner rather than later will depend on the extent to which both countries see an imperative to turn their numerous complementary interests into practical deeds.