bluuebunny/crossref_metadata_2025 huggingface dataset:
The First Russian Translation of Marcel Proust’s Novel “Swann’s Way”: (Based on the Materials of the Publishing House “World Literature”)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Arias-Vikhil Marina A.
Published: June 2023

It follows from the materials of the publishing house “World Literature” that it was this publishing house that for the first time in Russia paid attention to the work of Proust and carried out the first translation of several passages from his novel Du côté de chez Swann, thereby laying the tradition of Proust’s translation, which found its continuation in subsequent translations, first of all, in the translations of A.A. Frankovsky. Thus, the first translators of Proust in Russia were not B.A. Griftsov and Frankovsky, as is commonly believed, but an employee of the publishing house “World Literature” Maria N. Ryzhkina, the student of the Literary Studio under the guidance of the founder of the Russian translation school M.L. Lozinsky, who developed the theoretical and practical principles of translation in post-revolutionary Petrograd. What is curious, the publishing house “World Literature” was not mentioned in the well-regarded book “Marcel Proust in Russian Literature” (2000), although A.D. Mikhailov quoted there an article by V.V. Veidle in “The Modern West” magazine which had accompanied the first publication of Proust in Russian, translated by M.N. Ryzhkina. The materials of “The Modern West” magazine and the minutes of the meetings of the Editorial Board of the publishing house “World Literature” make it possible to trace how the collective opinion of the publishing house employees developed about the need to present Proust’s work to the Russian reader, what requirements were put forward for the work of a translator. The introduction of editorial protocols including the discussion of the work of M. Proust and the prospects for its publication in Russia by the “World Literature” publishing house into academic circulation significantly complements the picture of perception of the work of the great French innovative writer in Russia.
The Italian Diary. 1896. Introductory article, text prepared and commentaries by Marina Yu. Koreneva
Authors:   Institute of Russian Literature (Pushkin House) of the Russian Academy of Sciences, Koreneva Marina Yu.
Published: June 2023

The diary of Z.N. Gippius dates back to the time of the Italian journey that she made in 1896 together with D.S. Merezhkovsky and A.L. Volynsky (Flekser). The trip was undertaken in order to collect material for Merezhkovsky’s “The Romance of Leonardo da Vinci” and included visits to places associated with da Vinci’s life. Starting with a tour of the village of Vinci, where Leonardo was born, the travelers reached Amboise and visited the Clos Luce castle, the last refuge of the painter. The diary entries with brief observations and characteristics of the things seen by Gippius allow us to trace (although not completely) the route of the journey, which was later reflected in Merezhkovsky’s novel as well as in Volynsky’s “Leonardo da Vinci.” At the same time these records allow us to understand the emotional component of the trip. It took place in the middle of the “crisis” in the love relationship between Gippius and Volynsky, which, however, is not directly reflected in her notes equally ironic both towards Merezhkovsky and Volynsky. In the absence of Gippius’ letters for this period the published diary becomes an important document, which (for all its laconicism) gives a general idea of the circumstances of a joint trip to Italy. Of particular interest are the numerous pencil drawings made by Gippius during the sightseeing.
M.A. Maksimovich as the Addresse of N.V. Gogol's Letters (From the Commentary)
Authors:   A.M. Gorky Institute of World Literature of the Russian Academy of Sciences, Deryugina Lyudmila V.
Published: June 2023

The article is devoted to the relationship between N.V. Gogol and M.A. Maksimovich (1804–1873), his fellow countryman from the Poltava region. In his family there were writers and professors, they were proud of it, and Maksimovich himself from childhood dreamed of becoming a professor of botany in Moscow, but became a professor of Russian literature in Kiev and as a philologist and historian lived a fruitful scientific life. With Gogol he was brought together by his love for Little Russian songs. For the famous collection of songs by Maksimovich, Gogol offered several of his recordings and took part in its publication. Both were enthusiastic about the unrealized project to occupy university departments in Kiev together and turn it into a “new Athens,” launching an extensive educational program there. Their relations, invariably warm, were almost in absentia, until the autumn of 1849, when at the end of October Maksimovich arrived in Moscow, where Gogol then lived, and remained there for more than six months. In June they went together to their native lands, and in August 1850 Maksimovich visited Gogol in his village of Vasilyevka. Botany classes during the trip gave Gogol knowledge about Russia, important for the continuation of “Dead Souls.” Maksimovich, in his turn, left a portrait of the writer marked by professional observation and at the same time sympathetic understanding.
Rotas do teatro musical: West End, Broadway e o Brasil da Lei Rouanet
Authors: Guenzburger Gustavo , Machado Bernardo Fonseca
Published: June 2023

O teatro musical no Brasil sofreu uma mudança radical com a aproximação do século XXI, quando contextos locais e estrangeiros favoreceram a criação de novas rotas transnacionais para o comércio de musicais. Neste artigo analisamos os processos que levaram à recente recomposição do teatro musical no Brasil, que basicamente ocorreu em termos transnacionais. Na primeira parte, apresentamos o surgimento de “tecnopolíticas” que permitem à Inglaterra e aos Estados Unidos exportarem espetáculos, modelos e modos de produção da Broadwaye do West End. Na segunda parte, discutimos contradições na importação e adaptação destas fórmulas para o Brasil, um processo viabilizado pela criação de uma legislação específica de fomento à cultura, a Lei Rouanet.
Amapá: última fronteira cultural
Authors: Matos Bruno Sérvulo da Silva
Published: June 2023

Este artigo foi desenvolvido a partir da pesquisa realizada no Estado do Amapá com grupos teatrais contemporâneos. Por meio de entrevista e documentos foram investigadas ações, práticas diretamente ligadas às políticas públicas para a cultura, seja pela falta delas quanto pela má aplicação. Ainda que muitos dos relatos, quando descritos com clareza, nos pareçam “escandalosos”, são amplamente presentes e visíveis, porém, silenciados. Há, buscando similaridades no espaço e no tempo, registro de discursos do crítico e escritor Machado de Assis sobre o papel do Estado e até mesmo a visão elitista, em sua época, quanto ao fazer teatral.  Para além desta discussão, pretende-se com este trabalho demonstrar a distância, que não é apenas geográfica, no que tange aos incentivos fiscais para a cultura em relação às demais regiões do País. O Amapá se desenha como um Estado aquém em relação à sua relevância cultural e muito se deve por conta das ações e políticas dos agentes públicos.
Negociação processual com a Fazenda Pública à luz da teoria de Jürgen Habermas: exposição e proposta de alteração na redação do art. 13, §12 da lei nº 13.874/2019
Authors: Carneiro Gusmão Caroline
Published: June 2023

O presente trabalho tem como objetivo analisar a (in)viabilidade da negociação processual com a Fazenda Pública, nos termos propostos pelo artigo 13, §12 da Lei nº 13.874/2019, à luz da teoria de processualização do discurso desenvolvida por Jürgen Habermas. Verifica-se que a celebração de negócios processuais nos moldes propostos pela Lei nº 13.874/2019, limita a negociação processual à participação da Fazenda Pública e do Poder Judiciário, excluindo da relação a outra parte litigante; percebe-se, então, que vai de encontro à proposta de Habermas e do próprio Código de Processo Civil, pois, ao excluir a parte que litiga com a Fazenda Pública da celebração dos negócios processuais, foge do modelo de comparticipação e policentrismo, hierarquiza o público e o privado e prejudica a isonomia na formação do iter procedimental. Propõe-se, assim, uma nova redação para o art. 13, §12 da Lei nº 13.874/2019, com fundamento na teoria da processualização do discurso de Habermas, para incluir a parte na negociação processual com a Fazenda Pública e o juiz, garantindo-se a isonomia e o equilíbrio entre  a autonomia pública e autonomia privada. A metodologia utilizada será a dogmática, com o emprego do método de revisão bibliográfica, consistente na técnica de análise de livros, artigos, teses, dissertações, legislação, relatórios de órgãos oficiais e resoluções sobre os temas a serem pesquisados.O presente trabalho tem como objetivo analisar a (in)viabilidade da negociação processual com a Fazenda Pública, nos termos propostos pelo artigo 13, §12 da Lei nº 13.874/2019, à luz da teoria de processualização do discurso desenvolvida por Jürgen Habermas. Verifica-se que a celebração de negócios processuais nos moldes propostos pela Lei nº 13.874/2019, limita a negociação processual à participação da Fazenda Pública e do Poder Judiciário, excluindo da relação a outra parte litigante; percebe-se, então, que vai de encontro à proposta de Habermas e do próprio Código de Processo Civil, pois, ao excluir a parte que litiga com a Fazenda Pública da celebração dos negócios processuais, foge do modelo de comparticipação e policentrismo, hierarquiza o público e o privado e prejudica a isonomia na formação do iter procedimental. Propõe-se, assim, uma nova redação para o art. 13, §12 da Lei nº 13.874/2019, com fundamento na teoria da processualização do discurso de Habermas, para incluir a parte na negociação processual com a Fazenda Pública e o juiz, garantindo-se a isonomia e o equilíbrio entre  a autonomia pública e autonomia privada. A metodologia utilizada será a dogmática, com o emprego do método de revisão bibliográfica, consistente na técnica de análise de livros, artigos, teses, dissertações, legislação, relatórios de órgãos oficiais e resoluções sobre os temas a serem pesquisados.
O processo de Parceria Público-Privada (PPP) da iluminação pública inteligente em um município do interior do Paraná
Authors: Abreu Turco Denise , Dias Julie Cristini , De Castro Marcos , De Andrade Sandra Mara
Published: June 2023

Este artigo trata da descrição do processo de PPP da iluminação pública inteligente em um município do interior do estado do Paraná. O método utilizado foi estudo de caso único e o instrumento de coleta de dados, levantamento bibliográfico, levantamento documental e técnica de observação participante. Os dados receberam tratamento qualitativo com base na análise de conteúdo. Os resultados preliminares apontam para uma das práticas da ideologia neoliberalista, o processo de PPP (concretizado de acordo com cada uma das suas fases, pré-adjudicatório, adjudicatório e pós-adjudicatório) da iluminação pública de uma cidade classificada, conforme o Instituto Brasileiro de Geografia Estatística (IBGE), de centro-sub-regional “A”, e popularmente de “cidade do interior”. Outro resultado importante refere-se à condução da fase pré-adjudicatório, com o estabelecimento de leis e decretos municipais que dotaram o referido processo de capacidade legal/institucional. Quanto à capacidade administrativa, destaca-se a atuação do então prefeito, na vice-presidência da Frente Nacional dos Prefeitos (FNP), na temática concessões e PPPs, e do Conselho Gestor do Programa Municipal de PPPs (CGPPP), instituição da qual derivaram grupos de trabalho específicos, com realização de visita técnica a Belo Horizonte no estado de Minas Gerais.
Institucionalização de práticas restaurativas no manejo da violência contra a mulher em Belo Horizonte: trajetórias e perspectivas
Authors: Luiz Nunes Fábio
Published: June 2023

A justiça restaurativa é um conjunto de técnicas de solução de conflitos que se baseia na criatividade e na sensibilidade, a partir da escuta dos ofensores e das vítimas. Práticas como essas vêm sendo consideradas estratégia de intervenção em situações de violência doméstica e familiar contra a mulher. Esta pesquisa pretende identificar se a justiça restaurativa tem sido implementada em Belo Horizonte, nos últimos anos, para enfrentar a violência de gênero. Para tanto, lança mão de revisão de literatura científica em bases de dados on-line, materiais técnicos publicados, suporte estatístico oficial e fontes normativas pertinentes à temática. Observa-se que, em Belo Horizonte, práticas restaurativas stricto sensu ainda não são comuns no tratamento extrapenal de casos de violência de gênero, que tem se focado na rede de atendimento às vítimas e no acompanhamento dos ofensores por meio de grupos reflexivos. Levanta-se que as limitações a seu avanço se relacionam à forma como estão dispostos os textos normativos que viabilizam tais práticas e também a aspectos culturais que delineiam o receio de alguns do modelo restaurativo na atenção à violência doméstica. No entanto, vislumbra-se cenário futuro de implementação de técnicas restaurativas em situações dessa natureza no município citado.
A EFETIVIDADE DA POLÍTICA HABITACIONAL NO BRASIL: o Banco Nacional de Habitação e o Programa Minha Casa Minha Vida
Authors: Vieira de Almeida Andrade Hugo Márcio , Pereira Morais Leandro , De Paiva Cláudio César , Ribeiro Lima Faíque
Published: June 2023

O Brasil é um país que convive historicamente com a falta de habitações adequadas principalmente para populações de baixa renda, e esse problema afeta não só a qualidade de vida dessas pessoas, como também a capacidade de emancipação econômica e social. Dado esta questão, a problemática que instiga esta investigação é verificar como se deram e quão efetivas foram as ‘políticas habitacionais’ do Banco Nacional de Habitação e do Programa Minha Casa Minha Vida para a redução do déficit habitacional no país. Com relação a essa problemática, o objetivo geral deste trabalho é identificar e analisar as principais ações, programas e políticas habitacionais realizadas e como essas medidas impactaram no combate do déficit habitacional, assim como explicitar de que forma essas experiências foram bem ou malsucedidas no intercurso das suas aplicações. A investigação se justifica pela relevância da moradia adequada para o combate das desigualdades, bem como para a geração de renda, a valorização familiar e pessoal, a transformação social e a promoção de uma vida digna. Como resultado, aponta-se que as políticas habitacionais foram incapazes de lidar de maneira adequada com o problema da habitação.
Ações em redes de políticas públicas no IFPR campus Jacarezinho: Projeto Glucks - mensageiros da alegria
Authors: Freire Costa Danusa , Da Mota Darós Parente Claudia
Published: June 2023

Aliar as práticas de ensino, pesquisa e extensão é uma grande estratégia para promover uma formação focada na cidadania e na produção de conhecimento para superação das desigualdades sociais. O IFPR atua difundindo a importância dos projetos de extensão em seus Campi, dentre muitas iniciativas criativas e inovadoras foi criado em 2013 o projeto Glucks - Mensageiros da Alegria no IFPR Campus Jacarezinho.  Fruto da implementação de redes de políticas públicas que uniu atores com objetivos comuns, chamando-os a contribuir com a formação integral e a emancipação dos estudantes e com um forte apelo social e educacional.  Os estudantes se organizam, buscam parcerias e, em atividades planejadas, entram em contato direto com os idosos internos do Asilo São Vicente de Paulo, quando as trocas de experiência e de histórias de vida acontecem.  Com o objetivo de analisar o projeto e repensar as práticas de extensão no IFPR Campus Jacarezinho, este estudo faz uso da pesquisa bibliográfica e da análise documental numa pesquisa exploratória para compreender como as práticas de extensão têm sido implementadas e como a rede de políticas públicas contribui na formação integral dos estudantes. Ao analisar os documentos e registros é possível compreender que o projeto acolhe os atores e deixa marcas na vida de todos, levando a compreensão de que mesmo frente a tantas dificuldades, os resultados alcançados ao longo do trabalho revelam a grande relevância da prática da extensão e da necessidade do projeto Glucks - Mensageiros da Alegria para a formação dos estudantes do IFPR Campus Jacarezinho.
Popularização e prática em Ciências através da extensão universitária: relato de uma experiência
Authors: Mota Dos Santos Alex , D’Avila Gabriella Silva , Ferreira Paula Fabyanne Marques
Published: June 2023

A popularização e prática da ciência pode ser realizada em escolas através da extensão universitária. A partir de tal premissa, o objetivo deste artigo é revelar uma experiência de extensão para popularização e prática da ciência através do estudo da percepção de moradores da cidade de Ilhéus acerca dos resíduos sólidos. A metodologia contemplou a análise de dados e informações sobre resíduos sólidos no Brasil, no estado da Bahia, cidade de Ilhéus e aplicação do método de pesquisa Survey para avaliar a percepção. O principal resultado é a apresentação dos elementos básicos da prática da ciência para estudantes do ensino fundamental e médio. Sobre as atividades realizadas, destaca-se a percepção da coleta dos resíduos sólidos urbanos em Ilhéus. Nesse aspecto, a maioria dos inquiridos (46,2%) estão insatisfeitos, mas 78,3% respondeu que não comunica a prefeitura quando da observação de resíduos dispostos de forma irregular pela cidade.
Empowering Song: Music education from the margins
Authors: Fernandes José Fortunato
Published: June 2023

Resenha do livro Empowering Song: music education from the margins dos autores André de Quadros e Emilie Amrein. O livro traz uma proposta pedagógica de utilizar as artes para resgatar valores perdidos por pessoas marginalizadas. O livro aborda aspectos de diferentes áreas do conhecimento: eucação musical, psicologia, filosofia e sociologia.
Trilha do Conhecimento - Entrevista com a Profa. Dra Gleide Pinheiro
Authors: Ferraz Aline
Published: June 2023

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The periconceptional maternal intake of ultra-processed foods and the impact on imaging markers of early utero-placental vascular development: a hospital-based prospective observational cohort study
Authors: Steegers-Theunissen Regine , VOS Eline S. DE , Mulders Annemarie , Koning Anton , SMIT Hilco S. , Rossem Lenie van
Published: June 2023

Objective: To investigate whether periconceptional maternal intake of
ultra-processed foods (UPF) impairs first-trimester utero-placental
vascular development, and whether macronutrients and dietary patterns
substantiate the associations. Design: Prospective observational cohort.
Setting: Academic hospital. Population or Sample: Ongoing pregnancies.
Methods: 93 women completed a food frequency questionnaire from which we
calculated percentage of energy intake from UPF, intake of energy and
macronutrients and adherence to dietary patterns. We performed
sequential three-dimensional power Doppler ultrasounds of the
first-trimester utero-placental vasculature. VOCAL software, Virtual
Reality segmentation and a skeletonization algorithm were applied to
measure placental volume (PV), utero-placental vascular volume (uPVV)
and generate the utero-placental vascular skeleton (uPVS). Absolute
vascular morphology was quantified by assigning a morphologic
characteristic to each voxel in the uPVS (end-, bifurcation-, crossing-
or vessel point) and used to calculate density of vascular branching.
Main Outcome Measures: PV, uPVV, uPVS characteristics and density of
vascular branching. Results: Fully adjusted linear mixed models showed a
10%/day higher UPF intake was associated with increased first-trimester
density of vascular branching (bifurcation points: β=0.465√n,
95%CI=0.148;0.782). Higher carbohydrate intake of 10g/day was
associated with increased trajectories of uPVV (β=0.017,
95%CI=0.001;0.032) and uPVS (end points (β=0.286, 95%CI=0.062;0.511),
bifurcation points (β=0.004, 95%CI=0.003;0.006), vessel points
(β=0.772, 95%CI=0.137;1.408). The associations were substantiated by
the adherence to the “Snack” dietary pattern. Conclusions:
Periconceptional maternal intake of UPF is associated with impaired
first-trimester utero-placental vascular development, whereas the intake
of carbohydrates and strong adherence to a ‘Snack’ dietary pattern, is
positively associated with first-trimester utero-placental vascular
development.
AN EXPERIMENTAL INVESTIGATION OF A PORTABLE SOLAR THERMOELECTRIC FRIDGE FOR STORING SOME VACCINES
Authors: Salim Badran , Alsalam Bilal , Rifaie Mohammed Al
Published: June 2023

An experiment was conducted to determine the performance of a portable
thermoelectric fridge used for storing some vaccines powered by a solar
panel. The inner size of the cooler box tested was 240 mm × 240 mm × 170
mm with 8kg net weight of the fridge and it can accommodate 9.8 liters
of medical supplies. A thermoelectric module ESUMIC DC 12V was used in
the test. The thermoelectric hot side was cooled by using air,
meanwhile, the cold side of the thermoelectric was connected to the
inner heat sink to absorb heat inside the cooler box. The thermoelectric
was powered by a portable solar panel and battery directly to each
thermoelectric which had a power of 100 WP. The battery controls and
maintains the system’s voltage while it is being charged by the portable
solar panel. It also supports and supplies the system with enough power.
The cooler container was tested for one hour of daylight on 16 April, 21
May, 10 June, and 10 July respectively in 2021. The results showed that
the lowest temperature on the thermoelectric cold side and center of the
fridge was around 1.5°C and 8.6°C after one hour of working time. The
experimental COP obtained were ranging from 0.12 to 0.71. Moreover,
solar panels were the potential as power sources for thermoelectric
cooling systems.
Behavioral responses of leopard seals to human activity on the New Zealand coast
Authors: Forbes Giverny , Slooten Elisabeth
Published: June 2023

Leopard seals are encountered by people hundreds of times a year along
New Zealand’s coastline. They likely utilize New Zealand’s coastline for
rest and recuperation. Human activity could disturb leopard seals’ rest
and their subsequent responses could endanger human safety. This
research aimed to determine whether leopard seals changed their behavior
in response to human activity and whether these responses endangered
human safety. This research utilized video recordings of twenty-nine
individuals hauled out on the Otago coastline in New Zealand. The
behavior of leopard seals under control conditions was compared to that
expressed when people and/or dogs were present, and natural stimuli such
as rain. Leopard seals rested for most of their time budget under all
conditions but did so significantly less under the natural stimuli
conditions compared to control conditions (p = <0.001, p =
<0.001). Leopard seals lifted their heads significantly more
when dogs and/or people were present (p = 0.003, p = 0.02) than under
the control condition. They also moved significantly more when being
measured (p = 0.041) than was observed under the control condition.
Leopard seals did not express any behavior which could threaten the
safety of a person or dog during this study. These results suggest that
leopard seals can be disturbed by human activity when hauled out on
shore but are unlikely to endanger human safety. It is recommended that
wildlife managers maintain an exclusion zone of 20 m to ensure the
welfare of hauled out leopard seals and human safety. Further research
is required to assess to what extent the observed disturbances impact
the seals’ fitness and whether there is a cumulative impact.
Genome-wide association study of brain functional and structural networks
Authors: Cheng Ruonan , Yin Ruochen , Zhao Xiaoyu , Wang Wei , Gong Gaolang , Chen Chuansheng , Xue Gui , Dong Qi , chen chunhui
Published: June 2023

Imaging genetics studies with large samples have identified many genes
associated with brain functions and structures, but little is known
about genes associated with brain functional and structural network
properties. The current genome-wide association study (GWAS) examined
graph theory measures of brain structural and functional networks with
497 healthy Chinese participants (17-28 years). Four genes (TGFB3, LGI1,
TSPAN18 and FAM155A) were identified significantly associated with
functional network global efficiency, two (NLRP6 and ICE2) with
structural network global efficiency. Meta-analysis of structural and
functional brain network property confirmed the 4 functional related
genes and revealed two more (RBFOX1 and WWOX). These genes did not
significantly associate with any single structural or functional
connectivity. They were reported significantly associated with regional
brain structural or functional measurements in the UK Biobank project;
and showed differential gene expression level between low and high
structure-function coupling regions according to Allen Human Brain Atlas
gene expression data. Taken together, our results suggest that brain
structural and functional networks had shared and unique genetic bases,
consistent with the notion of many-to-many structure-function coupling
of the brain.
Henoch-Schönlein purpura: clinicopathologic correlation of cutaneous vascular IgA deposits and the relationship to leukocytoclastic vasculitis.
Authors: Helander S D , De Castro F R , Gibson L E
Published: June 2023

Significant cutaneous vascular IgA deposits are common in Henoch-Schönlein purpura but not in other vasculitides. The specificity for IgA vascular deposits for Henoch-Schönlein purpura is not well defined. To examine the specificity of IgA vascular deposits for this disease, we compared clinicopathologic features of 92 cases with IgA vascular deposits and a direct immunofluorescence impression of vasculitis with 90 similar cases without IgA deposits. Henoch-Schönlein purpura was diagnosed in 24% of cases with vascular IgA deposits on direct immunofluorescence examination. IgA deposits were frequent in erythema nodosum and venous stasis-related problems and in cryoglobulinemia, coagulopathic vasculopathies, and livedoid vasculitis. Of our cases, 78% exhibited vascular fluorescence with multiple conjugates. No histologic or immunofluorescence pattern alone was specific. The diagnostic specificity for Henoch-Schönlein purpura is improved if gastrointestinal involvement, upper respiratory infection, or age < 20 years is present. We propose diagnostic criteria for Henoch-Schönlein purpura incorporating clinical findings yielding sensitivity and specificity > 90%.
The steroid-sparing effect of long-term plasmapheresis in pemphigus.
Authors: Søndergaard K , Carstens J , Jørgensen J , Zachariae H
Published: June 2023

Glucocorticoids and immunosuppressive agents can induce remission in most patients with pemphigus, but mortality remains at 5 to 15% due to complications from these drugs. We reviewed the adjunctive effect of long-term plasmapheresis in 8 patients with pemphigus. Four cases had been resistant to conventional therapy. One or two large-volume plasmapheresis treatments were given monthly for 5 to 73 months. All patients were in clinical remission within 2 months after the addition of plasmapheresis. Relapses of pemphigus seldom occurred, and the patients stayed in remission 90% (40-100%) (median and ranges) of the plasmapheresis period. In all cases the daily dose of glucocorticoid was reduced. The prednisone level could be decreased significantly from 38 (15-80) mg/day to 10 (5-35) mg/day (p = 0.008). The overall level of other immunosuppressive agents remained unchanged, except in one patient where cyclosporine was introduced. This first report of long-term plasmapheresis demonstrates clinical efficacy in pemphigus and a considerable steroid-sparing effect.
Interferometry: a new method for no-touch measurement of the surface and volume of ulcerous skin lesions.
Authors: Altmeyer P , Erbler H , Krömer T , Duwe H P , Hoffmann K
Published: June 2023

A new interferometry procedure (Holon View measuring system) permits non-invasive and objective measurement of the surface, height/depth and volume of ulcerous lesions. The method, which uses a combination of the so-called phase-shift and gray-code technique, is new in dermatology. The measuring system consists of a diffraction grating projection system, a video camera and a computer-aided, digital image processing and analysis system. A diffraction grating consisting of 320 lines is projected onto the skin surface or a silicone impression of the ulcerous lesion. The course of the light-intersection lines is recorded by a video camera and read into an image computer. The special feature of the method is the combination of grey-code projection and a phase-shift procedure. For evaluation of the method in dermatology, 2,000 interferometric measurements of volume were carried out on objects of known volume, on silicone impressions and on leg ulcers. The accuracy of the method has been proven by means of the evaluation of objects of known volume. The results of interferometric measurements were compared with the values of the volume determined by water capacity and those of the surface determined by image analysis. The healing of a leg ulcer was followed over an 8-week period. The Holon View measuring system permits no-touch measurement of the volume and surface of ulcerous skin lesions with a high degree of accuracy and precision, in a short time.
Ultrastructure of murine epidermis treated with the vitamin D3 analogue KH-1060.
Authors: Kobayasi T , Gniadecki R , Serup J
Published: June 2023

A new highly potent analogue (KH-1060) of vitamin D3 has been recently shown to stimulate the growth and differentiation of keratinocytes. This study was intended to determine the effects of this new analogue on epidermis at the ultrastructural level. KH-1060 was applied topically on the backs of hairless mice for 4 weeks
The influence of the pH-value on the growth of Brevibacterium epidermidis in continuous culture.
Authors: Lukacs A , Korting H C , Lemke O , Ruckdeschel G , Ehret W , Braun-Falco O
Published: June 2023

Brevibacterium epidermidis is a major component of the bacterial flora of certain skin surface biotopes, characterized by a comparatively high pH-value. The presence of Brevibacterium epidermidis seems to be linked to the production of malodour. Skin surface pH has been found to be a major factor of bacterial growth on the skin. In order to find out if this might also apply to Brevibacterium epidermidis, this microorganism was grown in vitro in continuous culture using a chemostat. Specific growth rate and density of colony forming units were well correlated. While the organism grew readily from pH 5.5 to 8.5, this was not the case with a pH of 5.0. Thus pH-shifts induced by cosmetic procedures can only prevent unpleasant body odour due to abundant growth of bacteria if the pH-value is decreased to 5.0 or less.
A study of the steroid sulfatase gene in families with X-linked ichthyosis using polymerase chain reaction.
Authors: Nomura K , Nakano H , Umeki K , Harada K , Kon A , Tamai K , Sawamura D , Hashimoto I
Published: June 2023

We have studied the steroid sulfatase (STS) gene in three Japanese families with X-linked ichthyosis (XLI), using polymerase chain reaction (PCR). PCR was performed using three sets of intraexonic primers covering exons 1, 5 and 10. In affected individuals from two of the families, DNA was not amplified in any of the three exons, suggesting that XLI in these families was due to the complete deletion of the STS gene. In affected individuals in the remaining family, DNA was amplified in predicted sizes in exons 1 and 5, but not in exon 10, suggesting that XLI in this family was due to partial deletion of the STS gene including exon 10. These results suggested that STS gene deficiency is heterogeneous in Japanese families with XLI. PCR is useful for the rapid diagnosis of XLI, the differentiation of XLI from ichthyosis vulgaris, and genetic counseling of XLI families. The PCR method was not applicable for carrier detection.
Histamine-induced itch and alloknesis (itchy skin) in atopic eczema patients and controls.
Authors: Heyer G , Ulmer F J , Schmitz J , Handwerker H O
Published: June 2023

Alloknesis ("itchy skin") after histamine iontophoresis was studied together with itch sensations and skin reactions in 19 atopic eczema patients and 20 controls at the forearm and at the scapular area. Compared to controls, atopic eczema patients showed significantly reduced alloknesis or total lack of it in the area around a skin site to which histamine had been iontophoretically applied, although histamine elicited itching in most patients. As previously demonstrated, patients with atopic eczema also developed significantly smaller flares. However, covariance analysis revealed that the smaller alloknesis areas in atopic patients were not statistically related to the smaller flares. Our results suggest that in atopic eczema a diminished responsiveness of primary afferent nerves to histamine is not compensated by a higher central nervous sensitivity reflected in more vivid alloknesis responses to histamine. Therefore, we conclude that histamine is probably not the key factor of the spontaneous itch experienced by patients with atopic eczema.
Modulation of CD3-dependent lymphocyte proliferation by extracellular matrix proteins in atopic dermatitis.
Authors: Glinski W , Stepien-Sopniewska B , Korczak-Kowalska G , Glinska-Ferenz M , Gorski A
Published: June 2023

Patients with atopic dermatitis were found to have an about 7-fold increased spontaneous proliferative response of peripheral blood lymphocytes and an about 4-fold elevation of CD3-dependent lymphocyte transformation as compared to normal controls. The CD3-dependent lymphocyte response in patients with severe atopic dermatitis lesions was increased to a lower degree than in those with mild skin lesions. Despite a highly increased CD3-dependent lymphocyte response, the extracellular matrix proteins could induce further co-stimulation of lymphocytes in patients with atopic dermatitis, similar to that in normal controls. However, co-activation by type IV collagen was markedly increased in patients with severe lesions, whereas co-stimulations by both type I collagen and fibronectin were decreased in patients with mild lesions. This finding reflects presumably the changes in lymphocyte subpopulations and their activities related to the recirculation of these cells through the active skin lesions and to the contact of T cells with extracellular matrix proteins. The percentage of CD26-positive lymphocytes was also significantly (p < 0.05) increased in patients with severe atopic dermatitis. These data indicate that helper T cells are excessively activated in atopic dermatitis and that the function of beta-1-integrin receptors underlying the extracellular matrix protein-mediated co-activation of CD3-dependent lymphocyte responses is modified by disease severity.
Innervation of the skin of the forearm in diabetic patients: relation to nerve function.
Authors: Wallengren J , Badendick K , Sundler F , Håkanson R , Zander E
Published: June 2023

Complications of diabetes include sensory and autonomic neuropathy. The aim of the present paper was to study the degree of sensory and autonomic neuropathy and correlate these findings with the distribution and density of neuropeptidergic nerve fibers in the skin of the forearm of diabetic patients and healthy controls. We investigated 30 diabetics (24 type 1 and 6 type 2) and compared them with 13 healthy controls. There were no differences between the groups with respect to density and distribution of nerve fibers displaying immunoreactivity to the pan-neuronal marker PGP 9.5 and sensory and parasympathetic neuropeptides (substance P, calcitonin gene-related peptide and vasoactive intestinal peptide). By contrast, nerve fibers containing neuropeptide Y, a marker of sympathetic neurons, were reduced in number in the diabetic patients. C-fiber function (measured as the axon-reflex-evoked flare response) became impaired with increasing age in all subjects. The diabetic patients, however, showed a reduced flare compared to age-matched healthy controls. The reduction was particularly prominent in the younger patients (20-50 years). There was a greater reduction of the flare in neuropathic patients than in non-neuropathic patients, but there was no correlation between the degree of functional impairment and the duration of the disease.
Topical treatment of psoriatic plaques with 1 alpha, 24 dihydroxyvitamin D3: a multiparameter flow cytometrical analysis of epidermal growth, differentiation and inflammation.
Authors: Glade C P , Van Erp PE , Van Hooijdonk C A , Elbers M E , Van de Kerkhof PC
Published: June 2023

The clinical efficacy and tolerability of the vitamin D3 analogues calcitriol, calcipotriol and 1 alpha, 24 dihydroxyvitamin D3 in the treatment of psoriasis have been assessed in various clinical studies. In vitro and in vivo investigations have shown interference of these compounds with epidermal growth, keratinisation and inflammation. In this study we quantified the in vivo cell biological effects during treatment of psoriatic plaques with 1 alpha, 24 dihydroxyvitamin D3. By using a flow cytometric triple labelling procedure, we could discriminate different epidermal subpopulations, permitting precise assessment of epidermal cell cycle kinetics. Twenty patients with plaque-type psoriasis were treated in a double-blind placebo-controlled left-right comparative study with 1 alpha, 24 dihydroxyvitamin D3 ointment (4 micrograms/g applied once daily) for 8 weeks. Epidermal cell suspensions prepared from keratotome biopsies taken before and after treatment were stained with TO-PRO-3 iodide (a new DNA fluorochrome) and monoclonal antibodies against keratin 10 (as a marker for differentiation) and vimentin (as a marker for inflammation), simultaneously. The flow cytometric analyses showed a significant decrease of proliferating basal keratinocytes in verum-treated lesions, whereas such a decrease was not observed in placebo-treated lesions. The amount of keratin 10-positive keratinocytes increased and the presence of vimentin-positive cells decreased in cell suspensions derived from both verum- and placebo-treated lesions, but these effects were not significant. We conclude that multiparameter flow cytometry promises to be an adequate approach to assess the interference of antipsoriatic treatments with cutaneous inflammation, epidermal proliferation and keratinisation. Topical 1 alpha, 24 dihydroxyvitamin D3 seems to exert its in vivo antipsoriatic effect mainly through an inhibition of epidermal growth.
Frequency and activity of IgE-secreting peripheral blood B-cells in atopic eczema.
Authors: Thomas P , Pfützner W , Przybilla B
Published: June 2023

Increased immunoglobulin (Ig) E-levels are frequently found in the sera of patients with atopic eczema. To further understand the mechanisms underlying this increase of IgE, like enlarged number of IgE-producing cells, enhanced activity of IgE-producing cells or altered IgE metabolism, we analyzed the frequency and activity of IgE-producing B-lymphocytes within peripheral blood mononuclear cells of patients with atopic eczema. By use of a sensitive solid phase enzyme-linked immunospot assay (ELISPOT), IgE-secreting cells could be visualized within peripheral blood mononuclear cells of 14 individuals (12 patients with atopic eczema, one patient with impetigo contagiosa, one patient with allergic contact dermatitis) at a frequency of 10-1,120 IgE-secreting cells/10(5) B-lymphocytes. The number of IgE-secreting cells was markedly correlated with the corresponding serum IgE-level (r = 0.97). Secretory activity was also reflected by in vitro IgE production, which was assessed in parallel 7-day cultures and found to be related with actual serum IgE-levels. The enhanced serum IgE-levels in patients with atopic eczema seem to result primarily from an increased number of circulating IgE-secreting B-cells, which may also be found, however, in patients with elevated serum IgE-levels, showing different skin diseases.
Low dose versus medium dose UV-A1 treatment in severe atopic eczema.
Authors: Kowalzick L , Kleinheinz A , Weichenthal M , Neuber K , Köhler I , Grosch J , Lungwitz G , Seegeberg C , Ring J
Published: June 2023

Twenty-two patients with severe atopic eczema were included in a therapy study with UV-A1 (wavelengths > 340 nm) treatment. The patients were divided into two dose groups, each consisting of 11 patients. One group received 10 J/cm2 and the other 50 J/cm2 five times a week for 3 consecutive weeks. No topical or systemical steroids or antihistamines were allowed. Using the SCORAD index as a measure of disease activity before onset of therapy and after 10 and 15 treatments, we observed a significant improvement in both dose groups after 15 treatments (10 J/cm2: p < 0.05, 50 J/cm2: p < 0.005). After 10 treatments only the improvement in the 50 J/cm2 group was significant (p < 0.005)
Psoriasis and hepatitis C virus.
Authors: Yamamoto T , Katayama I , Nishioka K
Published: June 2023

We have analyzed 8 patients (6 men and 2 women, aged 52 to 70 years) with psoriasis associated with hepatitis C virus (HCV) infection among 79 psoriatic patients. Psoriasis preceded in 6 cases. One patient had generalized pustular psoriasis (GPP), and the others had psoriasis vulgaris (PV). The psoriasis area and severity index (PASI) score ranged from 2.7 to 32.4. Two of the patients were treated with interferon-gamma. Anti-HCV antibodies were detected in all cases by second generation enzyme-linked immunosorbent and recombinant immunoblot assay. HCV messenger RNA was demonstrated by reverse transcriptase polymerase chain reaction in the tissue sections of the lesions of 1 of the patients with PV and the patient with GPP, providing evidence for active viral replication in the skin lesion. HCV-related chronic active hepatitis might cause several immunological abnormalities. It is suggested that this infection might be one of the triggering factors of psoriasis.
Contact allergy to topical corticosteroids and systemic contact dermatitis from prednisolone with tolerance of triamcinolone.
Authors: Bircher A J , Levy F , Langauer S , Lepoittevin J P
Published: June 2023

We report the case of a 27-year-old female who had an allergic contact dermatitis to topical corticosteroids belonging to the corticosteroid groups A and D. Upon oral treatment with prednisolone a disseminated exanthema began within 24 h. Patch tests revealed sensitization to corticosteroids of group A, C and D, including prednisolone-21-acetate and betamethasone valerate, but not of group B corticosteroids such as triamcinolone. After intradermal testing of corticosteroids the exanthema flared again and the patient was treated with oral triamcinolone, with rapid improvement of her symptoms. A literature review revealed that exanthematous reactions after systemic treatment with corticosteroids have been rarely reported. Since corticosteroids are essential emergency drugs, a safe corticosteroid should be identified for such patients. Patch and intradermal tests may be used for that purpose.
Editorial
Authors: Juhlin  , Lennart
Published: June 2023

Abstract is missing (Editorial)
Inhibitory effect of vasoactive intestinal polypeptide and ketanserin on established allergic contact dermatitis in man.
Authors: Bondesson L , Nordlind K , Mutt V , Lidén S.
Published: June 2023

Neuromediators may influence the immune response. To investigate their potential immunomodulating role in established allergic contact dermatitis in man, the following neuromediators were tested: vasoactive intestinal polypeptide (VIP), serotonin, and the serotonin antagonists ketanserin, methiotepine and ICS-205-930. Positive patch test reactions were elicited by application of nickel sulphate for 48 h. The neuromediators were applied under patch test conditions after another 24 h. The test areas were measured before and 24 h after application of the neuromediators and biopsy specimens were taken for immunohistochemistry. After application of VIP at a concentration of 10(-5) mol/l, and of ketanserin at a concentration of 10(-4) mol/l, there was a significant reduction in the diameter of the test reaction. In addition, with VIP there was a reduction in the number of Leu 3a+ cells. Also tested was the influence of the neuromediators on the proliferative response of peripheral blood mononuclear cells from nickel-allergic subjects to nickel sulphate. The cells were cultured for 6 days and the neuromediators were added after 3 days. There was no effect on the proliferative response, except for slight inhibition by serotonin and by ketanserin at 10(-4) mol/l. More interferon gamma was found in the supernatants when VIP was added at 10(-5) and 10(-6) mol/l than in the control cultures. Thus, VIP and ketanserin may have an inhibitory effect on established allergic contact dermatitis. The effect of VIP is possibly mediated by an increased production of interferon gamma.
A novel endogenous mediator of cutaneous inflammation: leukemia inhibitory factor.
Authors: McKenzie RC , Paglia D , Kondo S , Sauder DN.
Published: June 2023

Keratinocytes produce a variety of cytokines, including leukemia inhibitory factor. We hypothesised that this cytokine may play a pro-inflammatory role in the skin and tested this hypothesis by injecting recombinant leukemia inhibitory factor (1-100 ng) into the ear pinnae of C3H/HeJ mice. To other groups of animals, we injected boiled leukemia inhibitory factor or phosphate-buffered saline (negative control) or 0.4 ng human interleukin-1 alpha as a positive control. Following injection of 100 ng leukemia inhibitory factor, ear thickness, measured by micrometer, increased 66% over controls at 12 h and 100% at 24 h (overall p = 0.041 by analysis of variance). Injection of 0.4 ng interleukin-1 alpha caused greater ear swelling. Compared with controls, swelling increased by 67% at 6 h, 100% at 12 h and 340% after 24 h (overall p < or = 0.00001). Leukemia inhibitory factor (100 ng only) stimulated a 3.5-fold increase in leukocytes after 6 h. After 12 h, a 14-fold increase was seen in ears injected with 10 ng leukemia inhibitory factor and a 12-fold increase with 100 ng leukemia inhibitory factor, which remained elevated (17-fold) at 24 h (overall p = 0.0001). Injection of interleukin-1 alpha led to a 3.4-fold increase in leukocytes (mean per 20 high-power fields) after 6 h, a 14-fold increase at 12 h and a 25-fold increase at 24 h (overall p < or = 0.00001). These results demonstrate that leukemia inhibitory factor appears to be a mediator of cutaneous inflammation.
Treatment of lipoid proteinosis with etretinate.
Authors: Gruber F , Manestar D , Stasic A , Grgurevic Z.
Published: June 2023

No abstract available
Burning mouth syndrome: hypersensitivity to sodium metabisulfite.
Authors: Levanti C , Ricciardi L , Isola S , Cilia M , Guarneri F , Purello D'Ambrosio
Published: June 2023

No abstract available
Herpes zoster-associated trigeminal neurotrophic ulcer.
Authors: Nielsen NH , Petersen CS.
Published: June 2023

No abstract available
A case of atypical localized scleroderma presenting with pseudoainhum: treatment with tranilast, an anti-fibrotic agent.
Authors: Tajima S , Suzuki Y , Inazumi T.
Published: June 2023

No abstract available
Acquired zosteriform naevus flammeus: a cutaneous marker of central nervous system angiomatosis.
Authors: Requena L , Escalonilla P , Sarasa JL , Fariña C , Piqué E , Martín L , Salinas F.
Published: June 2023

No abstract available