bluuebunny/crossref_metadata_2025 huggingface dataset:
ФАКТОРИ ВИНИКНЕННЯ КРИЗОВИХ ЯВИЩ ТА ЗАБЕЗПЕЧЕННЯ СТАЛОГО РОЗВИТКУ ПІДПРИЄМСТВА
Authors: Хринюк Олексій , Очеретяна Олександра
Published: June 2021

У статті розглянуто ключові підходи до визначення поняття «криза підприємства», що уже зустрічалися у вітчизняній науковій літературі, а також вперше визначено три підходи до трактування поняття «сталий розвиток підприємства». Проведено порівняння цих термінів та визначено, що за своєю сутнісною характеристикою вони не мають спільних ознак окрім того, що сприяють змінам на підприємстві (у першому випадку – негативним, у другому – позитивним). Далі було проведено огляд факторів виникнення кризових явищ та факторів забезпечення сталого розвитку підприємства. В межах наведених класифікацій виділено групи подібних факторів та проведено їхній детальний порівняльний аналіз. На основі зробленого висновку про те, що криза та сталий розвиток мають схожі фактори, було зроблено припущення про те, що підприємства які впроваджують стандарти сталого розвитку у свою діяльність, є менш вразливими до кризових явищ.
SOCIAL NETWORKS AS A CATALYST OF DEVELOPMENT AND DISTRIBUTION OF SERVICES OF RESTAURANT ESTABLISHMENTS
Authors: Nezveshchuk-Kohut Tetiana , Yazina Viktoriia
Published: June 2021

The article is devoted to the principles of functioning and development of the restaurant industry, which is covered by an important component of the
hospitality industry. Today, the trend of using social networks among society is constantly growing, while social networks perform many functions, such as
communication, information, social and so on. Depending on the company's goals, social networks can be used as an image building channel, helpdesk,
communication platform or as a direct sales tool. Promotion through social media is a relatively inexpensive «pleasure» that allows businesses to have
direct contact with current and potential customers. The urgency of creating pages in social networks as a catalyst for the development and distribution of
services of restaurants is considered. Current examples of restaurants that actively promote their services on social networks and the effectiveness of their
work is growing. The international experience of popularization of restaurant services through social networks is considered. Particular attention is paid to
identifying the main aspects that need to be considered when distributing restaurant services through social networks. The main components in the innovative management of the restaurant business through social networks are identified. The necessity of applying the experience of creating pages in social
networks, especially during the spread of the Covid-19 pandemic, is substantiated and the peculiarities of creating, filling and maintaining a page are given.
The restaurant industry is considered as one of the priority areas of tourism development, which has a significant impact on the socio-economic development of the country. Social networks play an important role in the distribution of restaurant services and communication with customers on the Internet,
so social networks open a wide window of opportunity for the successful operation and development of restaurants. The process is currently underway in
Ukraine involvement of restaurants in social networks and the formation of each of them own style of activity in this field.
THE PERCEPTION OF SOCIETY ON JUDICIAL CANING AS THE FORM IMPLEMENTATION OF QANUN JINAYAH (PSYCHOLOGICAL PERSPECTIVE)
Authors: Nurbaiti Nurbaiti , Nisa Haiyun
Published: June 2021

The implementation of a rule and form of punishment to create a safe and prosperous society will have an effect and impact on the fabric of social life. The implementation of judicial caning stipulated in the Qanun Jinayah has gained diverse views from society. The purpose of this study was to determine how society's perceptions of the implementation of judicial caning. This study used a qualitative method with observation and focus group techniques. A total of 31 people from 3 (three) regions in Banda Aceh City were selected as research respondents using purposive sampling techniques. The results point out that the perceptions that arise from the society are influenced by knowledge and views on judicial caning and its implementation as well as the psychosocial conditions of the society. Society does not quite understand the nature of Jinayah law, the purpose of punishment, and the order as well as the law to be realized. On the other hand, society also considers that judicial caning can provide a deterrent effect and learning to the society so that it does not violate the Sharia law.
Bicentenario y Centenario en la UAA
Authors: Martínez Ruíz Velasco Jesús
Published: June 2021

En el marco de los festejos por el Bicentenario del ini-cio de la Independencia Nacional y el Centenario del inicio de la Revolución Mexicana, la Universidad Autónoma de Aguascalientes (UAA) ha desarrollado una serie de eventos y actividades entre las que se encuentran:
Raíces y gestación de la UAA
Authors: Ruiz Velasco Jesús Martínez
Published: June 2021

El  antecedente  directo  de  la  UAA  fue  la  Escuela  de Agricultura,  que inició actividades  el  15  de  enero  de  1867,  meses  después  de  haberse instaurado  el  nuevo  gobierno  republicano  encabezado,  en  el  caso  de Aguascalientes,  por  el  Coronel  José  de  Jesús  Gómez  Portugal  Díaz, lo  anterior  en  el  contexto  de  la  recién  integrada  Junta  de  Instrucción Pública, donde además de crear la Escuela de Agricultura, se proponía también fundar escuelas de primeras letras. De hecho, el 11 de enero de 1867, se expidió el Plan General de Estudios del Estado de Aguascalientes, el cual estableció tres tipos de instrucción: primaria, secundaria y superior o profesional, siendo estos dos últimos encomendados a la Escuela de Agricultura.
¿Ayudan las evaluaciones aplicadas en el aula a mejorar el aprendizaje?
Authors: Muñoz Abundez Gustavo
Published: June 2021

La evaluación es una actividad con diversas funciones, se aplica a una variedad de acciones y objetos sociales, incluyendo a la actividad educativa y, por supuesto, a la enseñanza y al aprendizaje en particular. La idea de que es posible mejorar este último por medio de la evaluación, es decir, utilizándola formativamente, surgió al final de la década de 1960 (Scriven, 1967).
El modelo educativo basado en competencias y la evaluación de los aprendizajes.
Authors: Díaz Gutiérrez Juan Carlos , Rodríguez González Christian Irving Enrique , Velázquez González Felipe de Jesús , Villa Martínez Fernando Alejandro
Published: June 2021

Los  programas  educativos  del  Sistema  de  Universidades  Tecnológicas se desarrollan con base en las necesidades del sector productivo, desde donde se deriva el perfil profesional por competencias que debe caracterizar a sus egresados; luego, a partir de la competencia profesional de cada perfil y de la diversidad de contextos de aplicación, se desglosan conocimientos, habilidades  y actitudes  requeridos,  los  cuales  analizan  e integran  las  diferentes asignaturas que constituyen el mapa curricular de una carrera.
Primer Simposio Internacional de Manejo de Pastizales
Authors: Flores Ancira Ernesto
Published: June 2021

A finales del mes de noviembre del año 2003, se llevó a cabo en la Universidad Autónoma de Aguascalientes el I Simposio Internacional de Pastizales, esto debido a la preocupación de la situación que tenían en ese entonces los pastizales de México y, parti-cularmente, los del estado de Aguascalientes.
Contornos de sostenibilidad en la práctica docente
Authors: Acosta Collazo Francisco Javier
Published: June 2021

En 1987, como parte del marco internacional y de la crisis ambiental global, fue creado en la  Comisión  Mundial  sobre  Medio  Ambiente  y  Desarrollo un documento llamado Nuestro futuro común, (Informe Brundtland), en donde se señala que  el  desarrollo  y  medio  ambiente  no  pueden  estar separados, plantea el desafío de obtener al mismo  tiempo  la  sostenibilidad  económica,  la  ecológica y la social. En dicho informe se define el desarrollo sostenible como “el desarrollo que satisface las necesidades actuales sin comprometer  la  capacidad  de  las  futuras  generaciones  de  satisfacer sus propias necesidades” (Universidad para la Paz et al., 2002: 32)
La mediación pedagógica en redes sociales para el logro de competencias digitales
Authors: Ornelas Rodríguez Gustavo
Published: June 2021

La  Universidad  Pedagógica  Nacional  (UPN)  unidad  011  actualmente  oferta  la  Maestría en Educación Básica (MEB), cuyo perfil de ingreso considera a los profesionales de la educación que se desempeñan en educación básica. La primera generación está actualmente conformada por veintiún integrantes, de los cuales siete laboran  en  educación  preescolar,  once  en  primaria,  dos  en  secundaria  y  uno  en  CONAFE. Una de las competencias transversales que se espera que el profesional de la educación desarrolle es la siguiente: utiliza las tic en los procesos de aprendizaje y enseñanza de los alumnos (Gallegos, Guerra, Longoria, & Morales,  2009).  Aunado a  esta  delimitación  curricular  se  tienen  otros  referentes  normativos que establecen la necesidad de que los docentes desarrollen competencias para las habilidades digitales.
La práctica hace al maestro
Authors: Capistrán Gracia Raúl W.
Published: June 2021

La calidad de una interpretación musical está más íntimamente ligada a la calidad de la práctica, que a la cantidad de tiempo que se dedica al estudio de una obra. No basta sentarse al piano o tocar el violín por horas, sino que, las estrategias que se utilizan para aprender, dominar y memorizar una obra son vitales para obtener un excelente resultado interpretativo sobre  el  escenario.
Metodología y recursos didácticos para el curso de Ética Profesional
Authors: Pacheco González María de Lourdes
Published: June 2021

Las materias de Filosofía que se ofrecen en las diversas carreras profesionales suelen ser vistas como cursos difíciles o bien como materias de “relleno”, pero lo que no se puede negar es que son un espacio para reflexionar en torno a temas que, como seres humanos, nos preocupan por su injerencia en nuestra vida. En el caso concreto de los cursos de Ética Profesional, se busca que los futuros profesionistas reflexionen acerca de las implicaciones que su actividad profesional conlleva en la sociedad y la naturaleza; para ello, es necesario buscar la metodología y los recursos didácticos que mejor ayuden a alcanzar este objetivo.
En memoria del licenciado Héctor Manuel de León Hernández
Authors: (DEFAA) Departamento de Formación y Actualización Académica
Published: June 2021

En el presente texto, el lector conocerá parte de la vida y obra del licenciado Héctor de León, cronista de la Universidad Autónoma de Aguascalientes, reconocido como tal por sus diversas publicaciones acerca de la historia de dicha institución, así como por las diversas funciones que desempeñó en la misma.
Sólo una autobiografía docente
Authors: Galindo Soto Jonathan Alejandro
Published: June 2021

Hace poco, en un Diplomado de Innovación del Aprendizaje, nos solicitaron escribir una autobiografía. Quise empezarla con un análisis reflexivo tan estructurado y casi heroico como el de Miguel Jarquín (2012), con conciencia plena del significado histórico y filosófico de la labor educativa. Hablaría de Ausubel (1983), del plan de implementar los programas de estudio por competencias de la Organización de las Naciones Unidas para la Educación, la Ciencia y la Cultura (UNESCO, 2008), de los retos profesionales en el siglo XXI y cosas así. Pero intento ser honesto. No cínico, sólo honesto.
Retos para la Unidad Académica de Psicología extensión Jalpa
Authors: Pérez Márquez Edith Alejandra
Published: June 2021

"La Unidad Académica de Psicología de la Universidad Autónoma de Zacatecas ha cumplido ya 30 años formando profesionales en la salud mental, actualmente utiliza un programa diseñado en 1997, la licenciatura dura 5 años dividido en 2 años de área básica y 3 más para un área de acentuación entre las que se encuentran: clínica, educativa, social y laboral.

Al comparar el programa con el de las Universidades mejor puntuadas internacionalmente para estudiar esta licenciatura (Harvard y Cambridge), sale a relucir la necesidad de actualización de los programas en México, específicamente en Zacatecas.

Los temas de interés actualizados apuntan hacia los estudios en neurociencias, intervención familiar, prácticas comunitarias, entre otras. Así como personal que se dedique al desarrollo de las investigaciones que luego pueden ser propuestas de patentes para el sostenimiento de la Universidad”.
Una visión sobre los principios de la sustentabilidad para la enseñanza de la arquitectura
Authors: González Lugo Jonathan Hammurabi
Published: June 2021

El presente trabajo aborda una visión para la implementación real y práctica de los principios de la sustentabilidad en la enseñanza de la arquitectura, abordando, en primera instancia, una aproximación al concepto, así como los elementos y aspectos que la determinan. En seguida, se plantea la relación del término de sustentabilidad con la arquitectura y los procesos de enseñanza en las instituciones de nivel superior, aportando algunas apreciaciones que involucren de manera más comprometida a los estudiantes en la búsqueda de la sustentabilidad desde su disciplina y quehacer cotidiano.
Особливості психологічної готовності керівників банківських установ до управління персоналом
Authors: Бохонкова Юлія , Савельєва Єлизавета
Published: June 2021

У статті проаналізовано особливості формування психологічної готовності керівників банківських установ до управління персоналом. Виокремлено два основних теоретико-методологічних підходи психологічної готовності керівника до професійної діяльності: функціональний та особистісний. Автор статтіпід психологічною готовністю до управліннярозуміє загальну схильність керівників банківських установ до керівництва собою та іншими в професійному та особистому житті.Для проведення дослідження застосовано теоретичні методи, які передбачали впорядкування та систематизацію знань про психологічні аспекти управління персоналом в банківських установах; узагальнення теоретико-методологічних підходів до проблеми; розробку та обґрунтування теоретичної моделі.Обґрунтовано теоретичну модель психологічної готовності керівників банківських установ до управління персоналом, основними компонентами якої є: когнітивний, операційно-діяльнісний, особистісний,мотиваційний.Розкрито зміст і структуру, обґрунтовано систему організаційно-психологічних чинників, які впливають на рівень психологічної готовності керівників банківських установ до управління персоналом та визначено організаційно-психологічні умови її формування.Психологічну готовність керівників банківської установи до управління персоналом можна розвивати в процесі самоосвіти та в умовах післядипломної освіти. Найбільш ефективними з них є тренінги, семінари, дистанційне навчання, наставництво, відео курси, стажування.
Ключові слова: психологічна готовність, управлінська діяльність, банківська установа, регіональні філії,теоретична модель.
Usefulness of clinical and laboratory parameters for differentiation of biliary atresia from idiopathic neonatal hepatitis: Experience in a tertiary care hospital of Bangladesh
Authors: Sultana Kaniz , Haque Ariful , Musabbir Nadira , Anwar Syeda Afria , Hussain Faika , Mazumder Md Wahiduzzaman , Karim ASM Bazlul
Published: June 2021

Background: The two most common and important causes of neonatal cholestasis (NC) are biliary atresia (BA) and Idiopathic neonatal hepatitis (INH). There is no single test that can definitely differentiate these two entities.

Objective: To evaluate the diagnostic accuracy of clinical and laboratory parameters for diagnosis of biliary atresia.

Methods: This cross-sectional study was conducted at the department of Pediatric Gastroenterology and Nutrition of Bangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh, from August 2013 through July 2015 among purposively sampled infants with neonatal cholestasis. Results: Total 86 neonatal cholestatic cases were studied. Term baby and good birth weight are significantly higher in BA cases. The presence of persistent pale colored stool is significantly more in patients with BA (p 0.000). GGT is the only liver enzyme that was found to be useful differentiating BA from INH at a cut-off value ≥ 524U/L or 9.5 times higher than upper limit normal with sensitivity and specificity of 81.6% and 72.9% respectively. In the present study the diagnostic accuracy of persistent pale colored stool found to be highest (79.1 %).

Conclusion: The present study showed that Persistent pale colored stool and serum level of GGT with a cut-off value ≥524 U/L or 9.5 times higher than upper limit normal can be considered as predictive markers for differentiation of Biliary atresia from Idiopathic neonatal hepatitis.

CBMJ 2015 January: Vol. 04 No. 01 P: 30-36
Analysis of heavy metal contents in some commercial turmeric samples available at Dhaka, Bangladesh
Authors: Rahman Md Ataur , Akter Taslima , Akter Rahima , Sarkar Bidduth Kumar , Md Rafiquzzaman -
Published: June 2021

Nowadays, the use of spices and other herbs have extensively increased due to their medicinal values all over the world. However, the monitoring of heavy metal contamination in spices has also been increased in recent years. A study has been conducted to determine the concentration of eight heavy metals such as Lead (Pb), Cadmium (Cd), Chromium (Cr), Arsenic (As), Zinc (Zn), Iron (Fe), Copper (Cu) and Manganese (Mn) in mainly three different types of turmeric samples (Curcuma longa). The turmeric samples analyzed were (i) Unpacked bulk powder available at three different local markets in Dhaka (ii) Packed and marketed by three branded companies, and (iii) Raw turmeric directly collected from different local farmlands. The samples were analyzed using Atomic Absorption Spectroscopy (AAS). The concentration of most of the heavy metals were found within the limit recommended by WHO (6.0000 ppm) except lead (12.3469 ppm) in unpacked-3 bulk sample. This study also showed the concentration of heavy metals were present in a lower amount in packed power samples compared to unpacked bulk powder samples. The result of this analysis would be helpful for public awareness in consumption of different spices. The concerned authorities who are responsible for monitoring and regulating the food chain in the market in our country may also get a great message about heavy metal contamination of spices.

Jahangirnagar University J. Biol. Sci. 9(1 & 2): 13-20, 2020 (June & December)
Population status and feeding behavior of black kite (Milvus migrans) in Dhaka city, Bangladesh
Authors: Haque Md Amdadul , Ahammed Rasel , Monirujjaman - , Islam Md Abraharul , Khan Md Nahid H , Rayan Syed A , Khan M Monirul H , Kabir Md Mofizul
Published: June 2021

The status and feeding behavior of black kite (Milvus migrans) in Dhaka city were studied from July 2015 to June 2017. Road transects and morning roost-count method were used for population estimation and distribution, whereas focal sampling method was used to study the feeding and foraging behavior. Based on roosting and foraging areas, five transects were selected for population estimation. Moreover, six different feeding areas were selected for identifying various types of consumed food and assessing the feeding behavior of black kite. The black kite population was estimated at (1296±5.87) in Dhaka city. The population density was estimated at 21.8/km2. Among selected five different transects, the recorded population ranged from 108.12±6.70, 8.34%) at S-3 (Mirpur to Ramna Park) to 805±11.88, 62.11% of individuals at S-5 (Gulistan to Demra). The present study revealed that black kites were distributed throughout the study area and the distribution was influenced by availability of food, water and roosting place. Based on the annual records, the highest population (1510±6.92) was found in 2016. Majority of black kites fed on offal and insects in study area. In garbage dumps, the highest rate of feeding was recorded in afternoon followed by in morning and lowest in the noon. Whereas in non-garbage feeding areas, the highest rate was recorded in the morning followed by in the afternoon and lowest in the noon. Among four different foraging strategies, food collection by kites standing on the ground and intraspecific cleptoparasitism was never observed during study period while interspecific cleptoparasitism (against crows) was the highest number (193.67±2.77, 68.43%).

Jahangirnagar University J. Biol. Sci. 9(1 & 2): 35-48, 2020 (June & December)
Design, tecnologia assistiva e a doença de Parkinson: Uma revisão bibliográfica sistemática sobre talheres adaptados
Authors: Marques Larissa Raquel Ferro , Fernandes Nathan Martins , Paschoarelli Luis Carlos
Published: June 2021

A Doença de Parkinson é uma patologia que surge entre indivíduos idosos e causa uma séria de acometimentos físicos que influenciam as Atividades da Vida Diária, como por exemplo, a alimentação. O presente estudo objetivou mapear e analisar as pesquisas experimentais envolvendo a avaliação de artefatos adaptados que auxiliassem no processo de alimentação de pessoas com Doença de Parkinson, a partir de uma Revisão Bibliográfica Sistemática (RBS). A pesquisa foi realizada em três bases de dados: Scopus, Web Of Science e Science Direct, utilizando diferentes strings de busca. Foram encontrados inicialmente trezentos e noventa (390) artigos, e após a aplicação de critérios específicos, foram analisados cinco (5) artigos. Os resultados responderam à questão de pesquisa e objetivos da revisão, assim como identificou lacunas relacionadas ao desenvolvimento e análise de talheres adaptados, especialmente na área do Design de Produto. Como limitação, elencou-se a baixa produção relacionada à temática, assim como a utilização de abordagens pouco direcionadas à problemática e ao ponto de vista do usuário.
O ecossistema empreendedor, o direito aplicável as startups no Brasil e a atuação do Advogado
Authors: Oliveira Rafael Ferst de , Veiga Deivid Jonas Silva da , Silveira Dieison Prestes da , Brutti Tiago Anderson , Silva Joselia Cristina Siqueira da , Silva Geovane Barbosa da , Scheffer Denise da Costa Dias , Silveira Adriele Prestes da , Guntzel Cristiane
Published: June 2021

Este artigo tem o objetivo de compreender as prováveis implicações das aceleradoras de startups na economia brasileira e suas nuances jurídicas no Direito brasileiro, mensurando o impacto de sua atividade e as formas pelas quais elas atuam. A abordagem metodológica que estrutura esta pesquisa é a qualitativa, de cunho bibliográfico, com abordagem do tipo hipótética dedutiva, cujo o exame dos dados ocorreu por meio da Análise Textual Discursiva, abrangendo consultas a informações públicas disponíveis sobre os programas brasileiros que assessoram as organizações em análise. O roteiro da investigação inicia-se com o estudo conceitual do ecossistema empreendedor e das startups à luz do Direito Empresarial; prossegue-se com uma digressão a respeito das oportunidades que a inovação pode gerar, especialmente no âmbito dos pequenos negócios. Em seguida, busca-se compreender a participação do investidor anjo, e seus aspectos jurídicos. Por fim, são examinados os papeis do advogado frente aos principais desafios do direito em relação a expansão de startups no cenário nacional. Por meio deste estudo foi possível compreender o impacto da presença de aceleradoras de startups na economia, bem como as soluções jurídicas para o desenvolvimento consistente do ecossistema empreendedor brasileiro.
Representação social: Uma revisão teórica da abordagem
Authors: Sousa Karine Nogueira de , Souza Priscila Cristiane de
Published: June 2021

O presente artigo objetiva apresentar a Teoria das Representações Sociais, criada por Serge Moscovici em 1961, bem como as contribuições que diversos autores criaram a partir dela. Este estudo faz um revisão bibliográficas por meio de artigos científicos e livros de diversos estudiosos que buscam compreender e explicar a abordagem a partir da prática diária do ser humano, sendo esta uma leitura da realidade constituída por meio dos pensamentos dos indivíduos de um determinado grupo, que juntos produzem um núcleo central, onde são traduzidos suas ideias, pensamentos e a compreensão sobre um determinado objeto ou fenômeno. A Representação Social como abordagem, possui grande importância nos estudos onde se busca a compreensão de fenômenos sociais para criar mecanismos adequados de atendimento as necessidades de determinado grupo. O presente artigo traz ainda a contextualização histórica e epistemológica da teoria, os processos de objetivação e ancoragem, a função da representações sociais e as formas de conhecimento consensuais e reificadas, além das abordagens teóricas: cultural, estrutural e societal.
Hypertonia, COPD és Covid-19. Fókuszban az antihipertenzív terápia
Authors: Farsang Csaba
Published: June 2021

Chronic obstructive pulmonary disease is a very common comorbidity of hypertension and it is often unrecognised by physicians. The factors involved in the pathomechanism of both diseases should be realised when choosing treatment. Among factors, hypoxia, increased tone of sympathetic nervous system and activation of renin-angiotensin-aldosterone system should primarily be considered. Vascular wall damage and endothelial dysfunction has an important role in both conditions. The goals of treatment are elimination of risk factors, optimizing the blood pressure, the consequential prevention of cardio-cerebrovascular, renal and pulmonary damage; finally prolonging the patients’ life and improving their quality of life as well. Both hypertension and COPD significantly worsen the condition of COVID-19 patients since they increase the severity of the disease and the rate of in-patients’ and their mortality. In the treatment of hypertension among COPD and COVID-19 patients there must be emphasized the medication inhibiting of renin-angiotensin-aldosterone system, such as angiotensin-converting en­zyme inhibitors or angiotensin-II AT1 re­cep­tor antagonists. Special attention concerned the beneficial effect of mineralocorticoid receptor antagonist spironolactone. Other antihypertensive drugs (calcium channel blockers, thiazide-like diu­retics, high selectivity β1 receptor antagonists) may supplement the treatment if necessary. Long-acting β2 receptor agonists, muscarinic receptor antagonists and inhalation corticosteroids may be administered in double or triple combination also in hypertension and COPD as well. It is important to note, that statin therapy and also vitamin D3 improve the condition of COVID-19 patients.
Epilepszia koronavírus-járvány idején
Authors: Szűcs Anna , Halász Péter , Narula Lalit
Published: June 2021

We aim to review the impact of COVID-19 pandemic on epilepsy and epilepsy-care. While the virus has no specific link with epilepsy, it may affect the nervous system both directly and indirectly, leading to seizures in several ways. The hyper-coagulable state occurring with the infection may cause strokes leading to seizures. The infection may first manifest in the form of disturbances of consciousness and behaviour, seizures, and even status epilepticus. The interactions of antiviral/antiepileptic drugs need to be taken into account during treatment. The hypercoagulable state induced by COVID-2 infection may cause stroke, which leads to seizures. The infection can occur also as an impaired consciousness of non-epileptic origin. Interactions of antiviral/antiepileptic drugs have also to be taken into account. The pandemic itself as well as quarantines and social distancing may cause anxiety and insomnia, challenge continuous antiepileptic supply; each one carrying the risk of seizing. Young epilepsy patients with learning disabilities and mental health issues are most vulnerable, justifying their hyper-protection. The danger of infection has highlighted the role of telemedicine. Internet-based video communication may ensure full care for chro­nic patients. Those methods favour bes­­ted patients with higher education. Epilepsy does not increase directly the risk of infection, but its comorbidities may worsen the course of the disease. Brain lesions and hypoxia, stress, insomnia and fever joining the infection increase seizure susceptibility. Because the danger of infection ma­de telemedicine an essential tool of pa­tient care, education and better computer supply for those in need is crucial.
Genotype × Environment Interaction and Stability Analysis for Root Yield in Sweet Potato [Ipomoea batatas (L.) Lam]
Authors: Ebem Emmanuel C. , Afuape Solomon O. , Chukwu Samuel C. , Ubi Benjamin E.
Published: June 2021

Sweet potato breeding in Africa, more especially in Nigeria, has mainly focused on improving productivity on farmers' fields and on fresh root consumption. In order to target the breeding program, the study was conducted to estimate the magnitude of genotype × environment interaction (G × E) and to select stable and high yielding sweet potato genotypes for fresh root yield and root Cylas severity in two locations, and to identify the most discriminating and representative test environments in Nigeria. The 41 genotypes were evaluated across two diverse environments using a randomized complete block design (RCBD) with three replications. Data were collected on total number of roots per plant, number and weight of marketable roots per plant, fresh root yield, and root Cylas severity. The data were subjected to analysis of variance using the Generalized Linear Model procedure of SAS 9.2 where genotype was treated as a fixed factor and replication treated as a random variable. Stability analysis was conducted using Genotype and Genotype x Environment Interaction (GGE) bi-plot. Environment, genotype, and G × E interaction variances were highly significant (p < 0.01) among the assessed agronomic traits. Moreover, the analysis of variance revealed highly significant (p < 0.01) differences among genotypes, environments, and G × E interaction effects for all the studied traits. The GGE biplot analyses identified three promising genotypes—G13, G11, and G14—that possess both high mean root yield and high stability, closest to the ideal genotype for root performance and consistency of performance across environments. This study provides valuable information that could be utilized in a breeding program to ameliorate local clones of sweet potato in Nigeria.
Multi-Detailed 3D Architectural Framework for Sound Perception Research in Virtual Reality
Authors: Llorca-Bofí Josep , Vorländer Michael
Published: June 2021

The presentation of architectural design in simulation environments demands strong 3D modeling abilities. Architects usually demonstrate presentation skills that mostly address researchers in the building simulation field. However, there is still a gap between the architect’s deliverable and the contextual scenario for overarching research purposes, mainly caused by the lack of knowledge in the areas where research disciplines overlap. This dilemma is particularly present in the practice of 3D modeling for sound perception research in virtual reality since the building modelers must also gather diverse pieces of knowledge into a contained scenario: ranging from sound sources, sound propagation models to physically based material models. Grounded on this need, this article presents a comprehensive framework, defined by the visual and acoustic cues—geometries, materials, sources, receivers, and postprocessing—on one side and three levels of detail on the other. In this way, very specific research application needs can be covered, as well as a modular concept for future modeling demands. The interconnection between every model element is particularly designed, enabling the assembly among different modalities at different levels of detail. Finally, it provides targeted modeling strategies for architects, depicted in one indoor and one outdoor demonstration for auditory-visual research.
In utero Exposure to Excessive Estrogen Impairs Homologous Recombination and Oogenesis via Estrogen Receptor 2 in Mice
Authors: Mu Xinyi , Tu Zhihan , Chen Xuemei , Hong Yi , Geng Yanqing , Zhang Yan , Ji Xingduo , Liu Taihang , Wang Yingxiong , He Junlin
Published: June 2021

The association between the accumulation of synthetic chemicals with estrogenic activity and risks to oogenesis has become a growing concern. This study indicates that in utero estrogen exposure can affect homologous recombination in early oogenesis and influence the reproductive potential and lifespan of female offspring. We conducted this study in developing mouse ovaries using two different models: oral doses administered to the mother, and fetal ovary cultures. Our analyses of meiotic fetal oocytes suggest that 17-β-estradiol induces gross aberrations in prophase I events, including delayed meiotic progression, increased unrepaired DNA damage, and altered homologous recombination levels. These effects were mainly mediated by estrogen receptor 2 (ESR2) activation. Mid-gestation exposure to estrogen also led to delayed primordial folliculogenesis after birth, impaired follicle development after prepuberty, and ultimately reduced the total litter size of the offspring. This raises the concern that maternal exposures to substances activating ESR2 may compromise the fertility of the exposed female fetus.
Pan-Cancer Metastasis Prediction Based on Graph Deep Learning Method
Authors: Xu Yining , Cui Xinran , Wang Yadong
Published: June 2021

Tumor metastasis is the major cause of mortality from cancer. From this perspective, detecting cancer gene expression and transcriptome changes is important for exploring tumor metastasis molecular mechanisms and cellular events. Precisely estimating a patient’s cancer state and prognosis is the key challenge to develop a patient’s therapeutic schedule. In the recent years, a variety of machine learning techniques widely contributed to analyzing real-world gene expression data and predicting tumor outcomes. In this area, data mining and machine learning techniques have widely contributed to gene expression data analysis by supplying computational models to support decision-making on real-world data. Nevertheless, limitation of real-world data extremely restricted model predictive performance, and the complexity of data makes it difficult to extract vital features. Besides these, the efficacy of standard machine learning pipelines is far from being satisfactory despite the fact that diverse feature selection strategy had been applied. To address these problems, we developed directed relation-graph convolutional network to provide an advanced feature extraction strategy. We first constructed gene regulation network and extracted gene expression features based on relational graph convolutional network method. The high-dimensional features of each sample were regarded as an image pixel, and convolutional neural network was implemented to predict the risk of metastasis for each patient. Ten cross-validations on 1,779 cases from The Cancer Genome Atlas show that our model’s performance (area under the curve, AUC = 0.837; area under precision recall curve, AUPRC = 0.717) outstands that of an existing network-based method (AUC = 0.707, AUPRC = 0.555).
Exposure to Copper Compromises the Maturational Competency of Porcine Oocytes by Impairing Mitochondrial Function
Authors: Chen Jingyue , Cui Zhaokang , Qiu Yawei , Zhang Xingxing , Chen Fang , Wang Huili , Xiong Bo , Miao Yilong , Gao Qian
Published: June 2021

Copper (Cu) is an essential trace element for animals, and also an important nutritional component for the normal physiology and metabolism of animal reproductive systems. An excess or lack of Cu will directly or indirectly affect animal reproductive activities. However, the effect of Cu, in particular excessive Cu, on the reproductive performance of sows has not been studied. Here, we report that excessive Cu had negative effects on oocyte maturation and organelle functions. We showed that Cu exposure perturbed porcine oocyte meiotic maturation and impaired spindle/chromosome structure, resulting in a defective spindle assembly, as well as the abnormal distribution of actin dynamics and cortical granules. In addition, single-cell transcriptome analysis identified the target effectors of Cu actions in porcine oocytes, further demonstrating that Cu exposure affects the mitochondrial distribution and function, leading to the high levels of reactive oxygen species, DNA damage, and early apoptosis of porcine oocytes. These findings demonstrate that Cu exposure causes abnormalities in the mitochondrial distribution and function, resulting in the increased oxidative stress and levels of reactive oxygen species, DNA damage, and apoptosis, ultimately leading to a decreased porcine oocyte quality.
Bone Morphogenetic Protein Antagonist Gremlin-1 Increases Myofibroblast Transition in Dermal Fibroblasts: Implications for Systemic Sclerosis
Authors: Duffy Laura , Henderson John , Brown Max , Pryzborski Stefan , Fullard Nicola , Summa Lena , Distler Jorg H. W. , Stratton Richard , O’Reilly Steven
Published: June 2021

Objective

Systemic Sclerosis is an autoimmune connective tissue disease which results in fibrosis of the skin and lungs. The disease is characterized by activation of myofibroblasts but what governs this is unknown. Gremlin-1 is a BMP antagonist that is developmentally regulated and we sought to investigate its role in Systemic Sclerosis.

Methods

Dermal fibroblasts were transfected with Grem1pcDNA3.1 expression vectors or empty vectors. Various markers of myofibroblasts were measured at the mRNA and protein levels. Scratch wound assays were also performed. Media Transfer experiments were performed to evaluate cytokine like effects. Various inhibitors of TGF-β signaling and MAPK signaling were used post-transfection. siRNA to Gremlin-1 in SSc dermal fibroblasts were performed to evaluate the role of Gremlin-1. Different cytokines were incubated with fibroblasts and Gremlin-1 measured. Bleomycin was used as model of fibrosis and immunohistochemistry performed.

Results

Overexpression of Gremlin-1 was achieved in primary dermal fibroblasts and lead to activation of quiescent cells to myofibroblasts indicated by collagen and α-Smooth muscle actin. Overexpression also led to functional effects. This was associated with increased TGF-β1 levels and SBE luciferase activity but not increased Thrombospondin-1 expression. Inhibition of Gremlin-1 overexpression cells with antibodies to TGF-β1 but not isotype controls led to reduced collagen and various TGF-β pathway chemical inhibitors also led to reduced collagen levels. In SSc cells siRNA mediated reduction of Gremlin-1 reduced collagen expression and CTGF gene and protein levels in these cells. IL-13 did not lead to elevated Gremlin-1 expression nor did IL-11. Gremlin-1 was elevated in an animal model of fibrosis compared to NaCl-treated mice.

Conclusion

Gremlin-1 is a key regulator of myofibroblast transition leading to enhanced ECM deposition. Strategies that block Gremlin-1 maybe a possible therapeutic target in fibrotic diseases such as SSc.
Melatonin Attenuates Chromium (VI)-Induced Spermatogonial Stem Cell/Progenitor Mitophagy by Restoration of METTL3-Mediated RNA N6-Methyladenosine Modification
Authors: Lv Yinghua , Li Tianjiao , Yang Manman , Su Lihong , Zhu Zhendong , Zhao Sihang , Zeng Wenxian , Zheng Yi
Published: June 2021

Spermatogonial stem cells (SSCs) are the basis of spermatogenesis, and any damage to SSCs may result in spermatogenic disorder and male infertility. Chromium (Cr) (VI) is a proven toxin, mutagen, and carcinogen, perpetually detrimental to environmental organisms due to its intricate and enduring detoxification process in vivo. Despite this, the deleterious effects of Cr (VI) on SSCs and the underlying mechanisms remain poorly understood. In this study, we identified that Cr (VI) impaired male reproductive system in mouse testes and induced mitochondrial dynamic imbalance and mitophagy in SSCs/progenitors. Cr (VI) also downregulated the RNA N6-methyladenosine (m6A) modification levels in mitochondrial dynamic balance and mitophagy genes in SSCs/progenitors. Inspiringly, the toxic effects of Cr (VI) could be relieved by melatonin pretreatment. Melatonin alleviated Cr (VI)-induced damage to male reproductive system and autophagy in mouse testes. Melatonin also attenuated Cr (VI)-induced cell viability loss and reactive oxygen species (ROS) generation, as well as mitochondrial dynamic disorders and mitophagy in SSCs/progenitors. The protective roles of melatonin against Cr (VI)-induced mitophagy were exerted by restoration of METTL3-mediated RNA m6A modification and activation of mitochondrial fusion proteins MFN2 and OPA1, as well as inhibition of the mitophagy BNIP3/NIX receptor pathway. Thus, our study provides novel insights into the molecular mechanisms for RNA m6A modification underlying the gene regulatory network responsible for mitochondrial dynamic balance, and also lays new experimental groundwork for treatment of Cr (VI)-induced damage to male fertility.
New Liquid Crystal Assemblies Based on Cyano-Hydrogen Bonding Interactions
Authors: Hagar Mohamed , Ahmed Hoda A. , Alnoman Rua B. , Jaremko Mariusz , Emwas Abdul-Hamid , Sioud Salim , Abu Al-Ola Khulood A.
Published: June 2021

A new selection of supramolecular liquid crystal complexes based on complementary molecules formed via hydrogen-bonding interactions is reported. All prepared complexes were prepared from 4-n-alkoxybenzoic acid (An) and N-4-cyanobenzylidene-4-n-(hexyloxy)benzenamine (I). FT-IR, temperature gradient NMR, Mass Spectrometer and Chromatography spectroscopy were carried out to confirm the -CN and −COOH H-bonded complexation by observing their Fermi-bands and the effects of the 1H-NMR signals as well as its elution signal from HPLC. Moreover, binary phase diagrams were established for further confirmation. All formed complexes (I/An) were studied by the use of differential scanning calorimetry and their phase properties were validated through the use of polarized optical microscopy Results of mesomorphic characterization revealed that all presented complexes exhibited enantiotropic mesophases and their type was dependent on the terminal lengths of alkoxy chains. Also, the mesomorphic temperature ranges decreased in the order I/A6 > I/A8 > I/A10 > I/A16 with linear dependency on the chain length. Finally, the density functional theory computational modeling has been carried out to explain the experimental findings. The relation between the dimensional parameters was established to show the effect of the aspect ratio on the mesophase range and stability. The normalized entropy of the clearing transitions (∆S/R) was calculated to illustrate the molecular interaction enhancements with the chain lengths.
The Human Gut Phageome: Origins and Roles in the Human Gut Microbiome
Authors: Townsend Eleanor M. , Kelly Lucy , Muscatt George , Box Joshua D. , Hargraves Nicole , Lilley Daniel , Jameson Eleanor
Published: June 2021

The investigation of the microbial populations of the human body, known as the microbiome, has led to a revolutionary field of science, and understanding of its impacts on human development and health. The majority of microbiome research to date has focussed on bacteria and other kingdoms of life, such as fungi. Trailing behind these is the interrogation of the gut viruses, specifically the phageome. Bacteriophages, viruses that infect bacterial hosts, are known to dictate the dynamics and diversity of bacterial populations in a number of ecosystems. However, the phageome of the human gut, while of apparent importance, remains an area of many unknowns. In this paper we discuss the role of bacteriophages within the human gut microbiome. We examine the methods used to study bacteriophage populations, how this evolved over time and what we now understand about the phageome. We review the phageome development in infancy, and factors that may influence phage populations in adult life. The role and action of the phageome is then discussed at both a biological-level, and in the broader context of human health and disease.
How to Apply FMT More Effectively, Conveniently and Flexible – A Comparison of FMT Methods
Authors: Varga Adorján , Kocsis Béla , Sipos Dávid , Kása Péter , Vigvári Szabolcs , Pál Szilárd , Dembrovszky Fanni , Farkas Kornélia , Péterfi Zoltán
Published: June 2021

Purpose

Metronidazol and vancomycin were long the two best options against Clostridioides (formerly Clostridium) difficile infections (CDI). Now, the cost of new drugs such as fidaxomicin directs us towards alternative treatment options, such as faecal microbiota transplant (FMT). Its effectiveness is similar to fidaxomicin. There are questions regarding its safety, but the biggest challenges are prejudice and inconvenience. Most protocols refer to FMT applied in the form of a solution. We investigated different modalities of FMT.

Methods

Instead of using nasoenteric tubes or colonoscopy, we place frozen or lyophilised stool in non-coated, size “00”, hard gelatine capsules or enterosolvent, size “0” capsules.

Results

We found that non-coated, size “00”, hard gelatine capsules are appropriate for conducting FMT. Capsules containing lyophilised supernatant with a low number of bacteria have been proven to be non-inferior to other FMT modalities. The primary cure rate in the supernatant group was 93.75%, and 66.67% in the sediment group. The overall cure rate was 82.14%. Depending on the protocol, 4–7 capsules are sufficient per patient. Capsules can be stored for up to one year at -20°C.

Conclusions

FMT is a feasible alternative to antibiotic treatments in CDI. Our method makes the process flexible and less inconvenient to patients. Long storage time allows a consistent supply of capsules, while small volume and formulation make the procedure tolerable.
Mobilizing Networks and Relationships Through Indigenous Food Sovereignty: The Indigenous Food Circle’s Response to the COVID-19 Pandemic in Northwestern Ontario
Authors: Levkoe Charles Z. , McLaughlin Jessica , Strutt Courtney
Published: June 2021

This paper explores the Indigenous Food Circle’s (IFC) response to the COVID-19 pandemic in Northwestern Ontario, Canada. Established in 2016, the IFC is an informal collaborative network of Indigenous-led and Indigenous-serving organizations that aims to support and develop the capacity of Indigenous Peoples to collaboratively address challenges and opportunities facing food systems and to ensure that food-related programming and policy meets the needs of the all communities. Its primary goals are to reduce Indigenous food insecurity, increase food self-determination, and establish meaningful relationships with the settler population through food. This community case study introduces the IFC and shares the strategies and initiatives that were used during the COVID-19 pandemic in 2020 to address immediate needs and maintain a broader focus on Indigenous food sovereignty. The food related impacts of the COVID-19 pandemic on Indigenous People and determining solutions cannot be understood in isolation from settler colonialism and the capitalist food system. Reflecting on the scholarly literature and the experiential learnings that emerged from these efforts, we argue that meaningful and impacting initiatives that aim to address Indigenous food insecurity during an emergency situation must be rooted in a decolonizing framework that centers meaningful relationships and Indigenous leadership.