bluuebunny/crossref_metadata_2025 huggingface dataset:
Inhibition of STAT3 alleviates LPS-induced apoptosis and inflammation in renal tubular epithelial cells by transcriptionally down-regulating TASL
Authors: Xu Jin-Wen , Wang Ming-Yan , Mao Yan , Hu Zheng-Yun , Miao Xiao-Lin , Jiang Feng , Zhou Guo-Ping
Published: January 2024

Background

Systemic lupus erythematosus (SLE) is a common autoimmune disease that impacts various organs. Lupus nephritis (LN) significantly contributes to death in children with SLE. Toll-like receptor (TLR) adaptor interacting with SLC15A4 on the lysosome (TASL) acts as an innate immune adaptor for TLR and is implicated in the pathogenesis of SLE. A transcription factor known as signal transducer and activator of transcription 3 (STAT3), which is known to be linked to autoimmune diseases, is also involved in the development of SLE.

Methods

Bioinformatics and real-time quantitative PCR (qRT-PCR) was used to detect the expression of STAT3 and TASL in peripheral blood of SLE patients and their correlation. Bioinformatics analysis, qRT-PCR, luciferase assay and chromatin immunoprecipitation (ChIP) were used to verify the regulation of transcription factor STAT3 on TASL. The expression levels of STAT3, TASL and apoptosis-related genes in LPS-induced HK2 cells were detected by qRT-PCR and Western blot. TUNEL staining were used to detect the apoptosis of HK2 cells after LPS stimulation. ELISA and qRT-PCR were used to detect the levels of inflammatory cytokines in the cell culture supernatant. TASL knockdown in HK2 cells was used to detect the changes in apoptosis-related genes and inflammatory factors. The expression level of TASL in LPS-stimulated HK2 cells and its effect on cell apoptosis and inflammatory factors were observed by knocking down and overexpressing STAT3, respectively. It was also verified in a rescue experiment.

Results

The expressions of STAT3 and TASL were higher in SLE than in healthy children, and the expression of STAT3 was positively correlated with TASL. Transcription factor STAT3 can directly and positively regulate the expression of TASL through the promoter region binding site. The expression of STAT3, TASL and inflammatory cytokines was elevated, and the change of apoptosis was up-regulated in LPS-stimulated HK2 cells. Inhibition of STAT3 alleviates LPS-stimulated apoptosis and inflammatory response in HK2 cells through transcriptional regulation of TASL.

Conclusions

These findings provide new insights into the transcriptional regulation of TASL and provide new evidence of a direct regulatory relationship between signaling nodes in the lupus signaling network.

Graphical Abstract
Association of body temperature and mortality in critically ill patients: an observational study using two large databases
Authors: Tan Daniel J. , Chen Jiayang , Zhou Yirui , Ong Jaryl Shen Quan , Sin Richmond Jing Xuan , Bui Thach V. , Mehta Anokhi Amit , Feng Mengling , See Kay Choong
Published: January 2024

Background

Body temperature (BT) is routinely measured and can be controlled in critical care settings. BT can impact patient outcome, but the relationship between BT and mortality has not been well-established.

Methods

A retrospective cohort study was conducted based on the MIMIC-IV (N = 43,537) and eICU (N = 75,184) datasets. The primary outcome and exposure variables were hospital mortality and first 48-h median BT, respectively. Generalized additive models were used to model the associations between exposures and outcomes, while adjusting for patient age, sex, APS-III, SOFA, and Charlson comorbidity scores, temperature gap, as well as ventilation, vasopressor, steroids, and dialysis usage. We conducted subgroup analysis according to ICU setting, diagnoses, and demographics.

Results

Optimal BT was 37 °C for the general ICU and subgroup populations. A 10% increase in the proportion of time that BT was within the 36–38 °C range was associated with reduced hospital mortality risk in both MIMIC-IV (OR 0.91; 95% CI 0.90–0.93) and eICU (OR 0.86; 95% CI 0.85–0.87). On the other hand, a 10% increase in the proportion of time when BT < 36 °C was associated with increased mortality risk in both MIMIC-IV (OR 1.08; 95% CI 1.06–1.10) and eICU (OR 1.18; 95% CI 1.16–1.19). Similarly, a 10% increase in the proportion of time when BT > 38 °C was associated with increased mortality risk in both MIMIC-IV (OR 1.09; 95% CI 1.07–1.12) and eICU (OR 1.09; 95% CI 1.08–1.11). All patient subgroups tested consistently showed an optimal temperature within the 36–38 °C range.

Conclusions

A BT of 37 °C is associated with the lowest mortality risk among ICU patients. Further studies to explore the causal relationship between the optimal BT and mortality should be conducted and may help with establishing guidelines for active BT management in critical care settings.
ER-positive and BRCA2-mutated breast cancer: a literature review
Authors: Li Pu-Chun , Zhu Yi-Fan , Cao Wen-Ming , Li Bei
Published: January 2024

BRCA2-mutated carriers have a high lifetime risk of breast cancer (BC), an early age of onset, and an increased risk of other cancers (including ovarian, pancreatic, and prostate cancer). Almost 70–80% of BRCA2-mutated BC are estrogen receptor (ER)-positive, which is a particular type of ER-positive BC that differs from sporadic ER-positive BC. This article reviews the clinicopathological features, treatment, and prognosis of ER-positive and BRCA2-mutated BC to provide a reference for clinical decision-making.
Optimizing cardiac amyloidosis assessment: utility of 1-h and 3-h 99mTc-PYP imaging
Authors: Imakhanova Aiganym , Ideguchi Reiko , Kawano Hiroaki , Maemura Koji , Kudo Takashi
Published: January 2024

Background

Transthyretin amyloid cardiomyopathy (ATTR-CM), characterized by the extracellular deposition of an insoluble amyloid protein in the heart, is one of the main causes of heart failure in elderly patients. In this study, our primary objective was to explore the diverse applications and temporal significance of 1-h and 3-h imaging using 99mTc-PYP in the context of ATTR-CM. Additionally, we compared tracer kinetics in the heart and bone to comprehensively assess the diagnostic advantages and time-related considerations associated with these two incubation periods.

Methods

Twenty-seven patients at Nagasaki University Hospital who underwent 99mTc-PYP planar, and SPECT cardiac imaging were classified into two groups (ATTR-CM-positive and -negative groups) based on the American Heart Association statement. Cardiac retention was assessed with both a semiquantitative visual score and a quantitative analysis. To assess bone accumulation, a ROI with an equal volume was drawn on the sternum and calculated as the bone-to-contralateral ratio (B/CL). We also evaluated correlation between heart-to-contralateral lung (H/CL) ratio and left ventricular wall thickness.

Results

Among patients who underwent 99mTc-PYP imaging, the H/CL ratio was significantly higher at 1 h than at 3 h regardless of the group (from 2.20 ± 0.36 to 1.99 ± 0.35, p < 0.01 in the positive group and from 1.35 ± 0.12 to 1.19 ± 0.21, p = 0.01 in the negative group). The gap of H/CL between highest H/CL of negative case and lowest H/CL of positive case was narrower in 3 h. On the other hand, correlation between H/CL and left ventricular posterior wall thickness tends to be clearer in 3 h (p = 0.12, r = 0.30 for 1 h, p = 0.04, r = 0.39 at 3 h).

Conclusion

Our study suggests that both 1-h and 3-h incubation times for 99mTc-PYP imaging have different benefits for ATTR cardiac amyloidosis. A one-hour incubation may be preferable for differential diagnostic purposes, while a three-hour incubation may provide greater utility in evaluating disease severity.
Structuring the complexity of drop-out from VET: a theoretical framework guiding empirical research perspectives
Authors: Krötz Maximilian
Published: January 2024

After more than 50 years of research on drop-out from Vocational Education and Training (VET), databases provide vast amounts of drop-out studies from around the globe that entail hundreds of potential drop-out factors. However, many scholars tend to explore the topic without detailed and theoretically grounded foundation. Several diverging research foci exist within the research field of drop-out from VET: Studies differ with regard to the analysed phase of drop-out (development, decision-making, paths after dropping out), the applied sample perspective (learners, educators, further stakeholders), and the overall research perspective that is applied based on a specific theoretical approach. Given the range of drop-out factors, stakeholders, and possible theoretical approaches within studies, this article aims at organising the research on the multi-facetted phenomenon for future endeavours by presenting a framework model that comprises a three-step recommendation: First, the model illustrates different phases (Development-, Decision-, Adjustment-Phase) of drop-out research that should be differentiated. Second, it is argued that the chosen sample perspective is highly relevant for drop-out research and must be chosen carefully. Third, the overarching disciplinary research perspectives on drop-out from VET, which scholars may adopt within their research, entail particular relevant variables and focal points and should therefore be discussed. Four examples of research perspectives (economical, psychological, sociological, pedagogical) are briefly presented, structured on a micro-, meso- and macro-level, to exemplify different theoretical accesses to drop-out research. Throughout the article, the novel organisation framework is explained and exemplified by illustrating relevant aspects of each research area and exemplary literature. The presented framework will help organising the research field and enable scholars to delimit their work more precisely, leading to a more traceable structure of further research efforts and more significant contributions to the state of knowledge.
Does teachers’ motivation have an impact on students’ scientific literacy and motivation? An empirical study in Colombia with data from PISA 2015
Authors: Suárez-Mesa Ana María , Gómez Ricardo L.
Published: January 2024

In this study we use data from the Programme for International Student Assessment (PISA) to investigate the effect of teachers’ motivation on students’ scientific literacy and motivation in Colombia. These relationships are explored using a multilevel modeling framework and through the lens of Self-Determination Theory. Although difficulties in achieving education quality in developing and emerging economies are commonly attributed to teacher motivation issues, and important policy measures are implemented based on this assumption, this topic remains largely empirically unexplored. The purpose of the study is to contribute to fill this gap and provide empirically based insights for a broader and more informed dialogue regarding the effect of motivation in the development of scientific literacy, and to the design and implementation of evidence-based policies, instructional practices, and interventions. In this analysis, we did not find a significant relationship between teacher motivation and either students’ scientific literacy or motivation. However, students’ interest in science and sense of self-efficacy were significantly associated with their own achievement. The results also show that teacher-directed instruction is the strongest predictor of scientific literacy as opposed to inquiry-based teaching. However, inquiry-based teaching was found to be a positive predictor of increased students’ motivation.
#AidToo, or when situation permits rape: sexual violence among humanitarian aid workers
Authors: Sauter Melanie
Published: January 2024

This article explores the prevalent issue of sexual violence against and among humanitarian aid workers, with a focus on why the aid sector creates a particularly permissive environment for sexual violence. Although the issue is primarily an industry problem, with both perpetrators and survivors being members of the aid community, humanitarian organizations have been hesitant to address the issue. The article argues that legal ambiguities, barriers to accessing justice, and organizational mismanagement contribute to the permissive environment in the aid industry. Drawing on secondary survivor testimonies and legal frameworks, I highlight the need for more tangible prevention and follow-up mechanisms for survivors based on the legal duty of care of aid organizations. The analysis underscores the need for a comprehensive and proactive approach to addressing sexual violence within the aid sector, grounded in an understanding of power dynamics and organizational culture.
Kvaal’s dental age estimation method applied to Brazilian adults—a cross-sectional test of validity
Authors: Mantovani Suzana , Petta Adriano , Arakelyan Marianna , Soares Mariana , Franco Ademir
Published: January 2024

Background

Dental age estimation of adults is a challenging procedure in forensic odontology. Radiographic techniques have enabled non-invasive age estimation of adults since the 90’s. Kvaal’s method based on the deposition of secondary dentin has demonstrated broad applicability in several populations. Population-specific studies with this method, however, are scarce in South America. This study tested the validity of Kvaal’s method in a sample of radiographs of Brazilian adults. The sample consisted of 192 periapical radiographs of 106 females (55.2%) and 86 males (44.8%) with ages between 20 and 80 years old. The permanent maxillary right (n = 84, 43.8%) and left (n = 108, 56.2%) central incisors were assessed based on Kvaal’s method.

Results

Lin’s coefficient of concordance between estimated (EA) and chronological (CA) ages was 0.800 (IC95% = 0.753; 0.847) (p < 0.001). The mean difference between EA and CA was − 2.84 years (p < 0.001). For females and males, separately, the mean differences between EA and CA were − 3.82 years (CI95% =  − 5.38; − 2.25) (p < 0.001) and − 1.86 years (CI95% =  − 3.56; − 0.17) (p = 0.031), respectively. Underestimations were predominant and increased with time.

Conclusion

After 28 years of the original publication, Kvaal’s method remains reliable for non-invasive dental age estimation of adults, especially for the analysis of the permanent maxillary central incisors of Brazilian individuals.
Comparison of nutritional values of Mucuna pruriens L. (velvet bean) seeds with the most preferred legume pulses
Authors: Boniface Florence , Washa Washa B. , Nnungu Stephen
Published: January 2024

The effectiveness of legumes in overcoming hunger and food insecurity is attributed to their accessibility. They have been recorgnised for their nutritional significance and their ability to provide food stability in tropical and sub-tropical regions. This study compared the nutritional values of Mucuna seeds with that of common legume pulses by analysing their percentage composition based on literature review. Similar to common legume pulses, Mucuna seeds have been found to contain promising nutritional value. However, unlike most preferred legume pulses, Mucuna seeds contain a notable quantity of anti-nutritional factors that interferes with its nutritional qualities. Besides being anti-nutritional, the compounds have bio-active potentials and have been associated with therapeutic and antioxidant activities. Notably, Mucuna pruriens L. is known to contain compounds with potential antiparkinsonian effects, such as L-Dopa and ursolic acid. Considering their high productivity and nutritional relevance, Mucuna seeds have been utilised as traditional foods in populations with lower incomes that suffer from chronic undernourishment. It should be noted that variations in agro-climatic conditions have been reported to impact the chemical composition of M. pruriens seeds. However, limited information on the chemical composition of M. pruriens seeds from different regions makes it challenging to compare their composition across various agro-climates. Furthermore, in order to support the widespread use of M. pruriens in different areas, further research is needed to determine the optimal conditions for cultivating highly nutritious, phytochemically rich, and commercially viable seeds. Additionally, it is important to evaluate the effectiveness of L-Dopa in treating Parkinsonian patients across a diverse range of populations.

Graphical Abstract
Associations Between Adiponectin and the Development of Diabetes in Rheumatoid Arthritis
Authors: Baker Joshua F , England Bryant R , Wysham Katherine D , Sauer Brian , Joseph Amy M , Lenert Aleksander , Roul Punyasha , Xiao Rui , Gillcrist Rachel , Johnson Tate , Cannon Grant W , Duryee Michael , Thiele Geoffrey M , Mikuls Ted R
Published: January 2024

Purpose

We evaluated associations between adiponectin and the risk of diabetes among patients with rheumatoid arthritis (RA), a systemic inflammatory disease associated with metabolic disturbance.

Methods

This prospective cohort study included adults with RA from the Veterans Affairs Rheumatoid Arthritis Registry. Adiponectin and inflammatory cytokines/chemokines were measured at enrollment on stored serum samples. Adiponectin levels were categorized, and clinical variables were described across categories (<10 μg/mL; 10-40 μg/mL; >40 μg/mL). Multivariable Cox proportional hazard models evaluated associations between adiponectin and incident diabetes adjusting for age, sex, race, smoking status, body mass index (BMI), disease-modifying therapy use, calendar year, and comorbidity. Testing for modification of effect in the context of elevated cytokines/chemokines was performed.

Results

Among 2595 patients included in the analysis, those with adiponectin levels >40 μg/mL (N = 379; 15%) were older and had lower BMI. There were 125 new cases of diabetes among 1689 patients without prevalent disease at enrollment. There was an inverse association between adiponectin and incident diabetes; however, the association was positive among patients with adiponectin levels >40 μg/mL. Patients with levels >40 μg/mL were at higher risk compared to those with levels 10-40 μg/mL (HR: 1.70 [1.34, 2.16] P < .001). Those with adiponectin levels >40 μg/mL had significantly higher levels of inflammatory cytokines with evidence of a modified effect of adiponectin on diabetes risk in the setting of inflammation.

Conclusion

The relationship between adiponectin and incident diabetes risk is U-shaped in RA. Patients with very high adiponectin levels have greater systemic inflammation and an altered relationship between adiponectin and diabetes risk.
Acne vulgaris - review on pathogenesis and treatment
Authors: Żmuda Bartłomiej , Żuberek Michał , Ślusarczyk Daniel , Pisera Piotr , Kiełkowicz Aleksandra , Popińska Zuzanna , Pactwa Filip , Jakubowska Wiktoria
Published: January 2024

Introduction:

Acne vulgaris is a common dermatological problem, resulting from a complex interaction of many factors. This article presents a comprehensive overview of the pathogenesis of this condition, examining key aspects such as inflammatory factors, sebum production, colonization by P. acnes, endocrine disruption and lifestyle influences. In addition, various treatments are discussed, including the effectiveness of isotretinoin-based therapy and the potential benefits of antibiotics and retinoids in specific patient groups.

Aim of study:

The aim of the study is to summarize the available knowledge about the Acne vulgaris. The epidemiology, etiology, and methods of treatment were summarized and described.

Materials and methods:

The literature available in PubMed database was reviewed using following keywords: “Acne vulgaris”, “Isotretinoin”, “Therapy of Acne”.

Conclusion:

Research into acne vulgaris has been extensive, yet variations in study methods and descriptions have prevented definitive conclusions. Tailored care for each patient is crucial due to these differences. The disease's development involves various factors including inflammatory mediators, excess sebum production, P. acnes colonization, hormonal imbalances, and lifestyle impacts. Isotretinoin remains the most effective treatment, albeit with potential side effects that need consideration. For specific patient groups, topical antibiotics and retinoids may offer beneficial effects.
Menetrier's disease - press review and summary of current knowledge
Authors: Markowiak Szymon , Wardęszkiewicz Marta , Jabłońska Wiktoria , Kasprzak Amelia , Świercz Maciej , Truchta Monika , Mańkowska Aleksandra , Kolano Agata , Pejas Anna
Published: January 2024

Introduction

Menetrier's Disease is a rare and mysterious stomach disorder characterised by giant gastric folds, excessive mucus production, and protein loss. This comprehensive research article examines Menetrier's Disease, focusing on its clinical features, diagnosis, and available treatment options. The article aims to provide a complete understanding of Menetrier's Disease, fill the knowledge gap, and encourage improved clinical management.

Description of the State of Knowledge

Menetrier's Disease is a rare condition, and its cause is still unknown, though it may be linked to previous viral and bacterial infections and increased expression of transforming growth factor-alpha (TGF-α). Diagnosis can be established by endoscopic examination and histological analysis of material from a full-thickness mucosal biopsy. Treatment options are limited and concentrated on symptom relief, while the outcome of the therapy may vary.

Summary

Menetrier's Disease presents significant difficulties in both diagnosis and treatment. This review outlines the clinical features, classification, diagnostic approaches, available treatment options, and prognosis for healthcare professionals and researchers seeking to understand this disease better. Better understanding of Menetrier's Disease is crucial to improve patient care and explore new, potential therapeutic avenues.
Parkinson’s disease – a frequent cause of dementia
Authors: Wardęszkiewicz Marta , Markowiak Szymon , Jabłońska Wiktoria , Kasprzak Amelia , Świercz Maciej , Truchta Monika , Mańkowska Aleksandra , Kolano Agata , Pejas Anna
Published: January 2024

Introduction and Purpose.
Parkinson's disease (PD) is a progressive neurodegenerative disorder with characteristic motor symptoms and often overlooked non-motor manifestations, including dementia. This research article aims to enhance our understanding of PD and its complex clinical course, ultimately contributing to improved patient care and management. Moreover, it is important to raise awareness of cognitive impairment associated with Parkinson’s disease, as it is an aspect of social exclusion and disability
Material and method.
This study is based on medical articles collected from the PubMed database spanning the years 2015-2023. The research was conducted through the analysis of keywords such as Parkinson’s disease, dementia, diagnose, tremor, cognitive impairment.
Brief description of the state of knowledge.
Parkinson's disease is established as a movement disorder, primarily attributed to the loss of dopaminergic neurons in the substantia nigra. Although there is no cure for PD, treatment options have expanded, including pharmacological and non-pharmacological approaches. Early diagnosis is vital for effective management, and a multidisciplinary approach is crucial in addressing the diverse needs of PD patients.
Summary.
Parkinson's disease, a multifaceted neurodegenerative disorder, presents a complex clinical picture that extends beyond motor symptoms to include dementia. This review highlights the etiology, clinical manifestations, diagnostic criteria, differential diagnosis, various treatment modalities. Understanding of Parkinson’s disease, particularly its association with dementia, is essential for healthcare professionals and researchers to provide comprehensive care.
Nanostructured p-PbS/p-CuO sulfide/oxide bilayer heterojunction as a promising photoelectrode for hydrogen gas generation
Authors: Zayed Mohamed , Aljaafreh Mamduh J. , Shaban Mohamed , Hezam Mahmoud , Mohamed Sodky H. , Rabia Mohamed , Marashdeh Mohammad , Al-Hmoud M. , Ahmed Ashour M.
Published: January 2024

Recently, the photoelectrochemical (PEC) water-splitting reaction for hydrogen (H2) production has been a competitive research route to realize clean and sustainable electric power. In this work, copper oxide (CuO) and PbS thin films were fabricated on commercial glass, respectively, using the techniques of successive ionic-layer adsorption and reaction and chemical bath deposition. These nanostructured thin films served successfully as photoelectrodes for the photogeneration of H2. In addition, a p-PbS/p-CuO bilayer system was also fabricated, and a remarkable boost in PEC efficiency was observed compared to pure CuO and PbS thin films. Optical examinations showed excellent absorbance properties of the p-PbS/p-CuO bilayer in the visible range, with a bandgap of ∼1.28 eV. X-ray diffraction analysis indicated a monoclinic CuO/cubic PbS crystalline structure with a particle size of ∼18 nm. The photocurrent density (J
ph) values were obtained using a three-electrode electrochemical cell in 0.3 M Na2S2O3 electrolyte. The p-PbS/p-CuO photoelectrode demonstrated a J
ph value of −0.390 mA cm−2, which is significantly higher than the values of −0.120 and −0.008 mA cm−2 for the pure PbS and CuO photoelectrodes, respectively. This improvement is attributed to the p-PbS/p-CuO oxide/sulfide bilayer heterojunction, which improved the visible light absorption and reduced the electron–hole (e–h) recombination. The effects of pH value, temperature light intensity, and wavelength were all additionally studied. Remarkably, the photoelectrodes were stable under a pH of ∼7, which makes them promising for H2 production using normal drinking/seawater. These findings confirm the ability of the prepared photoelectrodes to facilitate water splitting and H2 generation under various environmental, chemical, and illumination conditions.
Phytochemical analysis and antifungal efficiency of Origanum majorana extracts against some phytopathogenic fungi causing tomato damping-off diseases
Authors: Al-Otibi Fatimah , Alshahrani Reem A. , Alharbi Raedah I. , Yassin Mohamed Taha
Published: January 2024

Plant diseases represent one of the major problems causing yield loss of tomato crops, especially root rot and seedling damping-off diseases caused by some phytopathogenic fungi like Fusarium solani (Fs), F. oxysporum (Fo), and Macrophomina phaseolina (Mp) frequently detected in tomato either alone or in combination infection. The objective of the present study is to assess the antifungal activity of Origanum majorana extracts against the phytopathogenic fungi, Fs, Fo, and Mp, thereby avoiding controlling the disease with chemical fungicides. In this context, the acetonic extracts of O. majorana exhibited the highest antifungal activity against the tested phytopathogens. However, F. solani exhibited high resistance to Ridomil fungicide at the tested concentrations. A chemical analysis of the O. majorana acetonic extract was conducted to determine the main phytoactive constituents exhibiting fungicidal activity. In this regard, gas chromatography and mass spectrometry confirmed that 4-terpineol was the main phytoactive compound followed by γ-terpinolene exhibiting relative percentages of 24.36 and 8.26%, respectively. These results proved that the marjoram extract may contribute to the development of an alternative and natural fungicide to protect tomato crops from damping off and root rot diseases, avoiding the usage of chemical fungicides.
Study of photovoltaic integrated prefabricated components for assembled buildings based on sensing technology supported by solar energy
Authors: Liu Yuying , Zhang Hai , Chen Peng
Published: January 2024

In recent years, domestic and international policies to support energy-efficient buildings have been intensively introduced, and a consensus has been reached in the direction of green buildings. Building photovoltaic integration is a key technology to solve the demand for electricity in energy-efficient buildings. Meanwhile, prefabricated assembly house construction, as a common construction technology in the current building field, has the advantages of a short construction period, low project cost, a wide range of applications, and high structural stability. Green building and building industrialization are the direction of future construction industry development, combining building photovoltaic (PV) integration with assembly building, breaking down the whole structure into simple components in the factory standardization, batch production, and then on-site assembly, can reduce the mold cost, speed up the construction speed, and improve economic efficiency. The PV solar integrated assembled facade is in line with the concept of energy saving, low carbon, and environmental protection, with significant social benefits, which helps to promote rapidly in the market. In this article, by analyzing the performance and characteristics of PV modules, we propose the design method of PV-integrated prefabricated components for assembled buildings based on sensing technology, extract relevant design parameters from the database of building PV-integrated components, and test the feasibility of the modeling scheme in four stages of engineering design. The use of the results shows that the method of this article can target to improve the accuracy of PV-integrated prefabricated components, ensure the efficiency of component production and processing, and play an important role in supporting the widespread application of modern construction technology for building PV-integrated prefabricated assemblies.
Cohen’s Influence on Husserl’s Understanding of Kant’s Transcendental Method
Authors: Scagliusi Francesco
Published: January 2024

This article argues that Husserl’s interpretation of Kant’s “regressive method” was influenced by Cohen’s account of the “transcendental method.” According to Cohen’s epistemological reading of the Critique of Pure Reason, Kant’s transcendental method consists in explaining the “fact of science” by using a regressive procedure from this fact to its conditions of possibility. Husserl ascribes, as Cohen does, this method to Kant himself. First, he criticizes Kant for regressively deducing conditions of possibility that elude any type of intuitive fulfillment. Second, he understands Kant as a rationalist who wanted to advance intellectualism and oppose empiricism. Finally, Husserl holds that Kant’s concept of experience refers to scientific experience. All these points are central aspects of Cohen’s interpretation. Moreover, from Husserl’s own copy of Cohen’s Kant’s Theory of Experience we can observe that he had read §12 on Kant’s transcendental method. Therefore, there is a Cohenian influence on Husserl’s criticism of Kant’s method.
Self-assembled nanoscale entities: Preparative process optimization, payload release, and enhanced bioavailability of thymoquinone natural product
Authors: Akhtar Naseem , Ullah Zabih , Rashid Mohammad , Alshammari Abdulaziz Arif A. , Alshammari Anoud , Alawaji Razan , Khan Mohd Faiyaz , Al-Mutairi Abdulrahman , Khan Riaz A.
Published: January 2024

Thymoquinone (TMQ), present in Nigella sativa L., exhibits antioxidant, anti-inflammatory, and anti-apoptotic properties. Poor aqueous solubility, low oral bioavailability, hepatic first-pass metabolic constraints, and pH instability have limited TMQ’s in vivo use in clinical settings. This study designed and prepared thermodynamically stable, self-emulsified, nanoscale vesicles with the ternary diagram assistance to produce self-nanoemulsifying drug delivery system (SNEDDS). The TMQ-SNEDDS preparations used clove oil, isopropyl myristate (IPM) (1:1), Labrasol, and Transcutol-P. The SNEDDS mean droplet size varied between 72.85 and 98.42 nm, and approximately >70% TMQ was released within the first 4 h. The peak plasma concentration values of TMQSNE3 and TMQ suspension were 420.31 ± 35.23 and 98.51 ± 9.97 μg/mL, respectively, whereas time to achieve the peak plasma concentration values were 0.75 ± 0.12 and 1.0 ± 0.30 h, respectively. The area under the curve from time 0 to t (AUC0–t
) and the area under the moment curve from time 0 to t (AUMC0–t
) of TMQSNE3 were found to be 1838.63 ± 55.73 µg h/mL and 1909.59 ± 382.81 µg h/mL, respectively, which were highly significant (p < 0.05) in comparison with AUC0–t
(389.36 ± 87.08 μg h/mL) and AUMC0–t
(390.31 ± 184.55 μg h/mL) of the TMQ suspension. The relative bioavailability of TMQ was enhanced by 4.7-folds for the optimized TMQSNEDDS than that of the free drug suspension. The SNEDDS enhanced the bioavailability, which, in turn, positively affected the therapeutic efficacy of this naturally bioactive compound, TMQ, which has delivery and bioavailability problems owing to poor aqueous solubility.
Structure–mechanical property relationships of 3D-printed porous polydimethylsiloxane films
Authors: Zhu Xiaowei , Li Yue , Shi Yilun , Hou Lanjie , Wang Guoxian , He Zhoukun , Lan Xiaorong
Published: January 2024

Complex microstructures can be produced from different base materials by combining three-dimensional (3D) printing technology and ink formulations. The surface wettability of the 3D-printed porous polydimethylsiloxane (PDMS), particularly its superhydrophobic property, strongly depends on its physical structure. However, the mechanism underlying the effect of the microporous structure on the mechanical properties is not understood, which seriously constrains the structural–functional integration design of the 3D-printed superhydrophobic porous PDMS. To solve this problem, we studied the influence of the printing parameters on the mechanical properties in the compression and tension directions using a finite element method. The results showed that the load transfer path of the 3D-printed porous PDMS was along the overlapping area of the adjacent filaments. As the filament spacing decreased or the filament diameter increased, the elastic modulus of the porous PDMS was enhanced, improving its resistance to tensile and compressive deformation. A quantitative relationship was established between the relative densities of the porous PDMS films and their relative elastic moduli. This study provides theoretical guidance for the structural–functional integration design of 3D-printed superhydrophobic porous PDMS.
Die italienische Besatzungsherrschaft in Montenegro 1941 bis 1943
Authors: Goddi Federico
Published: January 2024

Ziel dieses Aufsatzes ist es, die Beziehungen zwischen dem italienischen Besatzungssystem und der montenegrinischen Gesellschaft während des Zweiten Weltkriegs zu rekonstruieren. Der italienische Faschismus priorisierte praxisorientierte Maßnahmen, die vor allem darauf abzielten, eine Neue Ordnung im Mittelmeerraum zu errichten. Exemplarische Einblicke in dieses repressive System liefert die Geschichte der italienischen Divisionen „Venezia“ und „Pusteria“. Die von diesen Großverbänden angewandten Strategien illustrieren den allgegenwärtigen Konflikt im italienischen Machtapparat. Daher untersucht Federico Goddi verschiedene Aspekte des Alltagslebens während der Besatzung und beleuchtet diese auch im Kontext der militärischen Repression und der ökonomischen Ausbeutung.
Lernende Polizei?
Authors: Mecking Sabine
Published: January 2024

Die Anti-Atomkraftbewegung gehörte zu den wichtigsten Protestbewegungen in der Bundesrepublik, sowohl aus gesellschaftlicher als auch aus polizeilicher Sicht. Obgleich die Neuen Sozialen Bewegungen im 20. Jahrhundert bereits intensiv erörtert wurden, sind dennoch Fragen zu den Interaktionen zwischen Protestierenden und Polizei sowie überhaupt zu den polizeilichen Reaktionen auf das gesellschaftliche Aufbegehren und den zum Teil damit einhergehenden Ausschreitungen offen. Die jüngere Gewaltsoziologie geht davon aus, dass der konkreten Situation eine hohe Relevanz zukommt. Entsprechend lenkt Sabine Mecking den Blick auf den spezifischen Protestraum und die Akteurinnen und Akteure vor Ort an den Bauplätzen der nuklearen Anlagen. Die vergleichende Analyse des polizeilichen Protestmanagements bei den Großdemonstrationen der Anti-Atomkraftbewegung in den 1970er und 1980er Jahren ist ein Beitrag zur Protest-, Gewalt- und Demokratiegeschichte der Bundesrepublik Deutschland.
THE EFFECT OF PSYLLIUM FIBER AND CHOKEBERRY FIBRE ADDITION ON THE QUALITY OF PROBIOTIC FERMENTED MILK
Authors: ZNAMIROWSKA-PIOTROWSKA AGATA , PETRUSHA OKSANA , PAWLOS MAŁGORZATA , KOWALCZYK MAGDALENA , BUNIOWSKA-OLEJNIK MAGDALENA , SZAJNAR KATARZYNA
Published: January 2024

Background. Fiber from fruit, vegetables and other sources of fiber can increase gut microbiota diversity and show anti-inflammatory activity. The use of fiber in the manufacture of probiotic fermented milk has excellent potential, as it can offer several benefits for both consumers and producers. In addition to its well-known physiological benefits, dietary fiber may reduce the risk of diseases of civilization. Consumers expect that current foods are health-promoting. Consumer awareness is increasing through an expanding variety of products and advertising campaigns favoring health-promoting foods, a trend that food manufacturers are also taking advantage of. The aim of the study was to determine the effect of psyllium fiber and chokeberry fiber addition in combination with probiotic cultures Bifidobacterium animalis ssp. lactis BB-12 and Lacticaseibacillus casei 431 on the quality of fermented milk. To investigate the effect of fiber on fermented milk quality, acidity, texture properties, syneresis and colorcolor were measured, moreover, an organoleptic evaluation and microbiological analysis were performed. Results and conclusion. Natural additives such as chokeberry fiber and psyllium fiber can be used in the production of milk fermented by Bifidobacterium BB-12 and L.casei. Psyllium fiber can be recommended for its syneresis-reducing properties. Whereas chokeberry fiber, due to its high polyphenol content, can be used as a natural colorcolorant and taste-enhancing additive. Adding fiber as chokeberry or psyllium positively stimulated the growth and survival of Bifidobacterium BB-12 and L. casei bacteria during storage. The hardness of the milk gel fermented by Bifidobacterium BB-12 or L. casei was significantly improved by adding psyllium fiber, increasing it by as much as about 2.5 N, and this trend was also maintained after 28 days of storage. Studies on using various fibers in fermented milk production should be continued to determine their health-promoting and technological potential.
PIERWIASTKI ŚLADOWE W PŁATKACH ŚNIADANIOWYCH - KORZYŚCI I ZAGROŻENIA ZWIĄZANE Z ICH KONSUMPCJĄ
Authors: POKORSKA-NIEWIADA KAMILA , SADOWSKA MILENA , WITCZAK AGATA , SZCZUKO MAŁGORZATA
Published: January 2024

Introduction. Breakfast flakes, contrary to their name, are eaten not only for breakfast, but also as snacks between meals. Children are considered to be the main consumers of flakes, but adults are also eager to choose this type of products. Such a great interest in breakfast flakes is, among others, due to a wide product range, the ease of preparation, low price and high content of nutrients, including trace elements. The aim of this study was to analyze the content of trace elements in breakfast flakes in terms of benefits and risks for consumers. Eleven types of breakfast flakes purchased at a local retail store were the material for the study. The analyses were carried out using ICP-AES (inductively coupled plasma atomic emission spectrometry) and GF-AAS (atomic absorption spectrometry with electrothermal atomization in a graphite cuvette). Results and conclusions. The analysis showed that the average iron content in all the analyzed flakes was 62.8 mg/kg, and the richest source of this element were multi-cereal flakes. Oatmeal was characterized by the largest amounts of zinc, copper and manganese. It was also noted that the consumption of a portion of oatmeal provides 57 % of the daily requirement of manganese for men and almost 73 % for women. Based on the results obtained, it was also found that the consumption of breakfast cereals does not pose a health risk related to the exposure of consumers to the adverse effects of elements supplied to the body while consuming these products.
CHARACTERISTIC OF VOLATILE COMPONENTS PROFILE IN POLISH WINES BY GC-MS
Authors: JAKKIELSKA DOROTA , WAWRZYNIAK RAFAŁ , FRANKOWSKI MARCIN , ZIOŁA-FRANKOWSKA ANETTA
Published: January 2024

Background. Wine is a complex mixture of various compounds with diverse structures and properties. Multiple factors influence the chemical composition of wine. Viticulture is at a disadvantage in Poland, compared to more traditional wine regions. Grapes grown in Poland have lower sugar content, which leads to lower alcohol content and higher acidity of produced wine, which could also be seen as an advantage. Aromatic compounds, which are the subject of this study, influence, along with other factors, the taste and aroma of wine. Results and conclusions. This paper presents results of gas chromatography-mass spectrometry (GCMS) analysis and characteristic of aroma profiles of Polish wines. We identified 94 volatile compounds in 13 red wines and 53 volatile compounds in 18 white wines, including the following groups of compounds: alcohols, acids, esters, carbonyl compounds, ethers, terpenoids, norisoprenoids, phenols, sulfur compounds and hydrocarbons. The wines were produced from various grape varieties. A comparison of obtained results, both between each other and with results obtained in different studies, showed differences in wine composition, based on various factors. Odor Activity Values (OAVs) were calculated to define the dominant aroma of the analyzed wines, the higher the OAV of a given compound is, the greater impact on wine aroma it has.
EIGHT OLD CULTIVARS OF APPLE TREES – AN EVALUATION OF THEIR POTENTIAL FOR USE BY THE PROCESSING INDUSTRY
Authors: OCHMIAN IRENEUSZ , SIKORA FRYDERYK , GAŁCZYŃSKA MAŁGORZATA , LACHOWICZ-WIŚNIEWSKA SABINA
Published: January 2024

Background. Fruit of old cultivars may contain more micro- and macronutrients and polyphenols than modern tree cultivars. This paper presents the results of a study on eight old cultivars of apple trees. The fruit was gathered in the Wolin National Park (Woliński Park Narodowy) from old uncultivated trees. Results and conclusions. Despite the lack of tree care, the fruit of all the cultivars studied contained small amounts of harmful heavy metals and nitrates. Different criteria are used to evaluate fruit by consumers and the processing industry. For consumers, taste is important, and a low sugar-to-acid ratio makes fruit much tastier. The Roter Herbstkalvill cultivar, despite containing the least sugar of all the cultivars tested, has the lowest sugar-to-acid ratio (3.3). The highest content of health-promoting polyphenolic compounds was found in the fruit of the following cultivars: Roter Herbstkalvill (734 mg/100 g DM) and Kaiser Alexander (701 mg/100 g DM). Due to their high dry matter content, the Geflammter Kardinal and Boikenapfel cultivars will be the best choice for the processing industry. Whereas cultivars with a low sugar content, which caramelizes at high temperatures - Roter Herbstkalvill and Weisser Winterkalvill - will be useful for flour production and baking.
ANALIZA UKŁADÓW EMULSYJNYCH Z OLEJEM Z KONOPI JAKO SUPLEMENTÓW WITAMINY K
Authors: JARZĘBSKI MACIEJ , NIYOBUHUNGIRO SHALOME , SMUŁEK WOJCIECH , FIUTAK GRZEGORZ , FILIPCZAK-FIUTAK MAGDA , SADY MAREK
Published: January 2024

Introduction. Vitamin K plays an important role in the blood clotting process, improving bone health, reducing vascular calcification and cardiovascular risk, and has anti-inflammatory properties. The poor water solubility of vitamin K is a barrier to its introduction into functional foods. This makes it necessary to develop innovative forms of vitamin K supplements based on emulsion systems. Emulsions with submicron-sized droplets shows greater stability compared to macroscopic emulsions. Another challenge for the food technology is the need for alternatives to artificial surfactants. Plant extracts containing saponins in their structure, such as the soap nut extract used in this work, can be considered an alternative. Results and conclusions. This study shows three optimal compositions of emulsions based on hemp oil (from Cannabis sativa L. seeds), stabilized with a soap nut extract in the amount of 0.025, 0.250 and 0.500 cm3 per 25 cm3 of the entire composition. Vitamin K was used as a health-promoting ingredient in an amount of 0.2 mg. After the emulsion systems were produced, they were examined in terms of particle/droplet sizes using dynamic light scattering. Their homogeneity was evaluated using an optical microscope. The dynamic viscosity was determined with a rotational rheometer. An ATR-FTIR analysis, as well color and pH measurements, of the emulsion were also carried out. All three emulsions tested were characterized by a high degree of stability after one month. The emulsions based on hemp oil whose droplet size is below 1 micrometer can provide an alternative to vitamin carriers. Whereas the soap nut extract may become an effective stabilizer/surfactant used in the food technology.
Comparative Analysis of Schistosoma japonicum from Pairing-to-Sexual Maturation based on iTRAQ Proteomics
Authors: Yang Wen-Bin , Luo Fang , Zhang Rui-Xiang , Zhang Wei , Sun Cheng-Song , Wu-Yun Qi-Mu-Ge , Quan Jing-Wei , Luo Yang , Hu Wei
Published: January 2024

Objective:

Schistosomiasis, which is caused by the schistosome worm, poses significant health challenges. Understanding the sexual development and maturation of schistosomes would provide valuable insight for preventing the transmission of schistosomiasis and pathologic damage to the host.

Methods:

Isobaric tags for relative and absolute quantitation (iTRAQ)-based proteomics was performed to monitor the dynamic proteomic profiles in Schistosoma japonicum during development from pairing-to-maturation. RNA interference (RNAi) experiments were used to elucidate sex-biased gene function.

Results:

Of the 2927 identified proteins, 58.6% showed differential expression after comparing sexes and developmental stages. Both male and female worms displayed a similar number of gender-differentially expressed proteins after pairing. However, these proteins exhibited significant gender-specific functions, with reproduction central in females, while males were enriched in metabolic processes. Females exhibited 73% of their time-variant protein expression during 22-26 days post-infection (dpi), while males had 62% during 18-22 dpi, indicating earlier maturation in males. Functional analysis revealed different peptidases expressed during male and female development and maturation. Sex-biased SjU2AF exhaustion led to worm development delay, abnormal reproductive organ development, and death.

Conclusions:

Comparative proteomics enhances our understanding of mechanisms underlying schistosome maturation and reveals a new potential target for chemotherapy and vaccines.
On the zeros of a new zeta-function
Authors: Šleževičienė Rasa
Published: January 2024

There is not abstract.