bluuebunny/crossref_metadata_2025 huggingface dataset:
Subcutaneous and orthotopic xenograft models of human bladder carcinoma in nude mice for epidermal growth factor receptor-targeted treatment
Authors: Vorontsova M. S. , Karmakova T. A. , Plotnikova E. A. , Morozova N. B. , Abakumov M. A. , Yakubovskaya R. I. , Alexeev B. Ya.
Published: November 2018

Introduction.Approaches based on the principles of a targeted therapy are considered a promising strategy that is capable to improve the effectiveness of treatment for bladder cancer (BC) patients.

The purposeof the study was to establish an orthotopic xenograft model of human BC in mice and to prove its suitability for experimental examination of drugs targeting the epidermal growth factor receptor (EGFR).

Materials and methods.The objects of the study were ectopic subcutaneous and orthotopic human BC xenografts established using EJ and 5637 human BC cell lines. The growth of orthotopic xenografts in vivo was assessed by magnetic resonance imaging. Tumor tissues were investigated using histological and immunohistochemical techniques.

Results.It was shown that EJ and 5637 xenografts exhibit a good reproducibility, a sufficient blood supply of the tumor tissues, a high level of EGFR expression, and different pattern of a subcellular receptor localization. Implantation and subsequent proliferation of human EJ or 5637 cells in the murine bladder mucosa presumably results in muscle-non-invasive tumor formation.

Conclusions.The EJ and 5637 xenograft models can be useful for investigation of the efficacy of EGFR-targeted biotherapeutic treatments.
Recombinant human PRAME immunization reducesPRAME-expressing tumor growth in mice
Authors: Finashutina Yu. P. , Lyzhko N. A. , Kasatkina N. N. , Kesaeva L. A. , Tikhonova V. V. , Misyurin V. A. , Baryshnikova M. A. , Misyurin A. V.
Published: November 2018

Intrоduction.Human antigen PRAME is preferentially expressed in a number of different tumor types and may be a potent target for anti-tumor immunotherapy.

Purpose.To study anti-tumor action of immunogenic mix recombinant PRAME protein and adjuvant in mice with innate immunity.

Materials and methods.C57BL/6 female mice were used for immunization with purified human recombinant protein PRAME. Human PRAME gene coding sequence was cloned in mammalian expressing vector pCEP4 and resulting plasmid was introduced in mouse melanoma B16F10 cells by transfection followed by RQ-PCR, Western blot and flow-cytometry analysis. Then stably PRAME-transfected melanoma cells were injected in mice.

Results.The mouse melanoma B16F10 cells stably expressing human PRAME protein were obtained. We demonstrate the 10-fold decreased tumor volume in mice with melanoma B16F10 expressing human PRAME after preventive immunization series with recombinant PRAME protein. The tumor volume reducing was correlated with high titer (6.14 × 10 5) of anti-PRAME antibodies in mice sera.

Conclusion.These data indicate that recombinant protein PRAME is immunogenic and may be a potent antigen for immunotherapuetics studies.
Preclinical trial of Bacteriosens used for the photodynamic therapyof malignant tumors, including prostate cancer
Authors: Morozova N. B. , Plotnikova E. A. , Plyutinskaya A. D. , Stramova V. O. , Vorontsova M. S. , Pankratov A. A. , Yakubovskaya R. I. , Makarova E. A. , Lukyanets E. A. , Kaprin A. D.
Published: November 2018

Introduction.Bacteriochlorins are the most promising photosensitizers absorbing in the near-infrared spectral region. Their use can enhance the efficiency of photodynamic therapy due to the deeper penetration of radiation into the tumor.

Objectiveto conduct a preclinical study of the photoinduced antitumor activity and biodistribution of Bacteriosens.

Materials and methods.Bacteriosens is a preparation based on meso-tetra(3-pyridyl)bacteriochlorin absorbing at 747 nm. Photoinduced cytotoxicity was investigated in vitro using human tumor cells: A549, Hep 2, BT-474, MCF-7, SK-BR-3, PC3, and EJ and murine tumor cells: S37, C26, and LLC. In vivo studies were performed in mice with large and small tumors (S37, LLC, and C26).

Results.In vitro investigation show that bacteriosens during optical irradiation led to the effective suppression of tumor cell growth in culture (the IC50 value varied from 0,08μМ to 1,21 μМ) and had no toxicity without exposure to light. The effective photodynamic therapy regimen using Bacteriosens in mice with inoculated small and large tumors of different genesis resulted in regression of a primary tumor node on 90–100 % of the animals in the absence of tumor recurrence within 90 days after treatment.

Conclusion.Bacteriosens is a promising agent for the photodynamic therapy of small and large tumors; it can be successfully used as an alternative, organ-sparing minimally invasive treatment for malignant tumors, including prostate cancer.
Equitoxicity Cisplatin-RONC® and Cisplatin-Teva at a single injection to mice and rats
Authors: Bukhman V. M. , Ermakova N. P. , Konyaeva O. I. , Kulbachevskaya N. Yu. , Sergeev A. A. , Chaley V. A.
Published: November 2018

Introduction.The development of high-quality domestic reproduced dosage form of сisplatin is necessary to improve the treatment conditions of cancer patients.

Purpose of research.Comparative preclinical study of acute toxicity of newly developed in SIC Oncology reproduced dosage form Cisplatin-RONC® with commercial preparation Cisplatin-Teva.

Materials and methods.The standard methods of estimation of acute toxicity of preparations on small laboratory rodents are used.

Results.Acute toxicity of the compared forms of cisplatin is not significantly different from the effect on the survival and body weight of experimental animals.

Summary.Compared generic and commercial formulations cisplatin almost equitoxic after a single intravenous administration to mice and rats.
Redes sociales y estudiantes: motivos de uso y gratificaciones. Evidencias para el aprendizaje
Authors: García-Ruiz Rosa , Tirado Morueta Ramón , Hernando Gómez Angel
Published: November 2018

Aunque las nuevas generaciones utilizan las redes sociales como un medio de comunicación habitual, en el ámbito educativo aún no se han utilizado de manera generalizada por los docentes como recurso didáctico. Conocer las gratificaciones que encuentran las nuevas generaciones al usar las redes sociales, permitirá al profesorado hacer un uso estimulante de estos medios en la educación secundaria y universitaria. El objetivo de este trabajo es conocer cuáles son las gratificaciones que encuentran los estudiantes de educación secundaria y universitaria al utilizar intensamente las redes sociales Facebook, Instagram y YouTube. Utilizando la teoría de Usos y Gratificaciones, se recogen datos a través de un cuestionario de estudiantes españoles de educación secundaria (N=260) y universitarios (N=315).  Los resultados muestran que los estudiantes de secundaria buscan una mayor presencia social y velan por su propia imagen, mientras que los estudiantes universitarios buscan entretenimiento. Finalmente, se discuten los resultados y las implicaciones para un uso estimulante y didáctico de las redes sociales en contexto de enseñanza-aprendizaje.
GDP vs genuine progress quantification of economic performance in South Korea and Malaysia
Authors: Hashim Mastura , Mohammad Sifat Imtiaz , Mohamad Azhar
Published: November 2018

Malaysia and South Korea, successful graduates of Asian Financial Crisis, employed different paths to recovery via Capital Control and IMF bail-out respectively. This paper tracks recovery trajectories of the two nations via orthodox and emergent growth indicators: GDP and GPI. We report unemployment, open-trade, fixed capital accumulation, and prior crisis to be influential determinants of both metrics, while credit and foreign exchange rate lack significance.
Repetición y variación. Un comentario sobre la pintura de objetos a propósito de la exposición El arte de Clara Peeters en el Museo del Prado.
Authors: González Carmen
Published: November 2018

Clara Peeters fue una artista activa en Amberes entre 1607 y 1621. Su obra pictórica, centrada en la representación de lo que a partir de mediados del siglo XVII se denominarían bodegones o naturalezas muertas, es reflejo de la cultura material, del gusto, de las necesidades y los intereses de una época. Aunque fuertemente arraigada en la tradición artística de su tiempo, su pintura aporta sutiles rasgos distintivos. Desde la perspectiva del espectador contemporáneo, algunos de esos rasgos propios suponen innovaciones que justifican que se emprenda una revisión de la relevancia de una artista con una visión profunda y moderna de las posibilidades de la pintura de su época. En este artículo se analizan algunas características de la obra de Peeters a partir de la magnífica exposición que le ha dedicado el Museo del Prado, realizada en colaboración con el Koninklijk Museum von Schone Kusten Royal Museum de Amberes. Teniendo en consideración el conjunto de las obras expuestas, se establecen conexiones con otras obras artísticas desde las cualidades específicas de la pintura de objetos y cosas.
Redefiniendo fronteras: La poética de la road movie en American Greyhounds (Héctor Muniente y Mario Aranguren, 2010)
Authors: García Ochoa Santiago
Published: November 2018

La road movie es un género norteamericano que surge a finales de los 60, en plena crisis del cine clásico, y que posteriormente se exporta a las cinematografías de todo el mundo, conociendo un espectacular desarrollo a finales del siglo XX. En el cine español su aparición coincide con la transición a la democracia (1975-1982) y aparece ligado fundamentalmente a la comedia, pero a partir de los 90 se desarrolla en diversas corrientes, entre las que destaca el “documental road movie”, actualmente en pleno apogeo, como lo demuestra American Greyhounds (2010). Esta película recoge las entrevistas de una serie de personas de clase baja que viajan en los míticos autobuses Greyhound, coincidiendo con un cambio político trascendental: el triunfo electoral de Obama.
Estudio exploratorio de las competencias sociales en niños de una escuela primaria de la Ciudad de Mérida/Exploratory study of social skills in children from an elementary school in the city of Merida, México
Authors: Pinto Loria Maria Lourdes , Madera Farfán Claudia Maribel
Published: November 2018

La competencia social es la capacidad para mantener buenas relaciones con otras personas, esto implica dominar las habilidades sociales (Bisquerra, 2007). Durante la escolarización, es especialmente importantes el desarrollo de las competencias sociales (Plazas et. al, 2010). El objetivo fue explorar la estructura de las relaciones interpersonales que se presentan dentro del grupo de alumnos de cuarto grado de primaria, así como conocer cuáles son las competencias sociales que están presentes en los niños durante los procesos de interacción. Se emplearon tres instrumentos: la Sociometría, la Escala de Comportamiento Social en la Escuela (SSBS) y la Escala Matson de Evaluación de las Habilidades Sociales en Niños (MESSY). La muestra fue de 23 participantes. Los resultados arrojan una correlación moderada entre los factores de Autocontrol y Sobre-confianza y entre los índices de Antipatía y la Sobre-confianza. La correlación entre la antipatía con el autocontrol, el comportamiento académico y las relaciones con sus compañeros fueron negativas y moderadas.
Literatura infantil en la música para piano española de la segunda mitad del siglo XX/Children’s literature in spanish music for piano of the second half of the 20th century
Authors: Mancheño Delgado Miriam
Published: November 2018

A lo largo de la historia de la técnica e interpretación pianística varios han sido los compositores que han mostrado interés por el joven intérprete, bien con la creación de métodos pianísticos bien con la composición de obras con un destacado componente infantil. En el conjunto de composiciones para piano de la segunda mitad del siglo XX en España se pueden encontrar un amplio número de obras donde se halla un interés renovado por el pianista novel. El estudio y análisis de este repertorio permite apreciar las diferentes maneras de acercarse a la literatura infantil de los compositores españoles en activo durante este período, siguiendo una línea no tan alejada a la marcada por la historiografía musical. En este artículo se pretende mostrar una serie de obras destinadas al intérprete principiante, clasificadas en cuatro grupos: 1) cuadernos con finalidad específicamente pedagógica; 2) obras que utilizan el folklore con valor formativo; 3) ciclos y cuadernos donde el componente infantil sirve de inspiración; 4) obras que incluyen nuevas técnicas pianísticas contemporáneas.
¿Cómo influye el tamaño del campo de texto en las respuestas a preguntas abiertas? Evidencias de un diseño experimental/The influence of box size on responses to open-ended questions: Results from a split-ballot experiment
Authors: León Carmen María , Aizpurúa Eva , Vázquez David
Published: November 2018

RESUMENEl diseño visual de los cuestionarios puede afectar a la calidad de los datos obtenidos, especialmente cuando se formulan preguntas abiertas donde los encuestados responden con sus propias palabras. En este trabajo se analizan los efectos de manipular el tamaño del espacio proporcionado para la respuesta en un conjunto de preguntas abiertas incluidas en un cuestionario auto-administrado sobre opiniones hacia la administración de justicia en España. Para ello se recurrió a un experimento split-ballot, dividiendo la muestra (N = 100) en dos mitades equivalentes que recibieron dos cuestionarios con el mismo contenido, pero con diferentes tamaños de campo de respuesta (pequeño y grande) en 16 preguntas abiertas. Los resultados muestran que los participantes que recibieron campos de texto grandes escribieron un mayor número de palabras en sus respuestas. Sin embargo, la manipulación en el campo de texto no influyó en 1) el número de temas abordados; ni en 2) el tiempo empleado para cumplimentar los cuestionarios. Sobre la base ABSTRACTThe visual design of questionnaires can affect the quality of the data obtained, especially when asking open-ended questions that respondents answer in their own words. In this paper, we analyze the effects of manipulating the size of the text boxes provided for answers to a set of open-ended questions in a self-administered questionnaire about opinions of the Criminal Justice system in Spain. For this, a split-ballot experiment was conducted dividing the sample (N = 100) into two equivalent halves. One half received questionnaires with small box sizes for the answers to the 16 open-ended questions while the other half received questionnaires with larger box sizes. The content on the questionnaires was the same. The results showed that those participants who received larger text boxes provided longer answers. However, manipulation of the text box did not influence 1) the number of issues addressed; or 2) response times. The results and their implications for questionnaire design are discussed.
Mecanismos para la formación de foliaciones tectónicas superpuestas a pliegues: ejemplos en el orógeno varisco del NW de España Mechanisms for the formation of tectonic foliations superimposed on folds: examples in the Variscan orogen of NW Spain
Authors: Aller J. , Bastida F. , Bobillo-Ares N. C.
Published: November 2018

Resumen: En algunos sectores de las zonas Cantábrica y Asturoccidental-leonesa se ha desarrollado un clivaje incongruente con posterioridad a los principales pliegues variscos. Para su análisis se han considerado los siguientes mecanismos: anti-flexural flow, anti-deformación longitudinal tangencial inversa, deformación homogénea y deformación en las capas incompetentes por traslación de las competentes. Los tres primeros corresponden a mecanismos de plegamiento operando en sentido inverso. En la Zona Cantábrica, el mecanismo esencial de formación del clivaje incongruente es la deformación homogénea con máximo acortamiento subvertical. Cuando el clivaje tiene distinta orientación en los dos flancos, esta es probablemente debida a un plegamiento posterior, como lo indica la presencia frecuente de clivaje de crenulación. En el caso de la Zona Asturoccidental-leonesa, el clivaje incongruente tiene siempre distinta orientación en ambos flancos y su formación ha sido interpretada como debida a deformación en las capas incompetentes por traslación de las competentes a la que se superpone una deformación homogénea con dirección de máximo acortamiento paralela al plano axial.Palabras clave: clivaje, plegamiento, deformación, modelización de estructuras, Orógeno varisco.Abstract: In specific areas of the Cantabrian and Westasturian-Leonese zones, an oblique cleavage develops subsequently to the formation of the main Variscan folds. Several mechanisms have been considered for its analysis: anti-flexural flow, anti-tangential longitudinal strain, homogeneous strain and deformation of the incompetent layers by translation of the competent ones. The first three correspond to folding mechanisms operating in a reverse sense. In the Cantabrian Zone the main mechanism for the formation of the oblique cleavage is homogeneous strain with a subvertical maximum shortening. When the cleavage has a different orientation in both limbs, this is probably due to a subsequent folding event, as indicated by the common existence of crenulation cleavage. In the Westasturian-Leonese Zone the cleavage has always a different orientation in both limbs and its formation has been interpreted as a result of deformation of the incompetent layers by translation of the competent ones with a superposition of homogeneous strain with máximum shortening parallel to the axial plane.Keywords: cleavage, folding, strain, modelling of structures, Variscan orogeny.
El peculiar registro del tránsito Bashkiriense/Moscoviense en la Zona Cantábrica (Carbonífero, Norte de España) The peculiar record of the Bashkirian/Moscovian transition in the Cantabrian Zone (Carboniferous, north of Spain)
Authors: Villa E. , Merino-Tomé O.
Published: November 2018

Resumen: El Carbonífero de la Zona Cantábrica muestra en el tránsito entre los pisos Bashkiriense y Moscoviense un contenido en foraminíferos (principalmente fusulinas) excepcionalmente rico, en el que aparecen asociaciones faunísticas desconocidas en la Cuenca de Moscú (estratotipo del límite inferior del Moscoviense). Este hecho podría indicar que la sucesión de la Cuenca de Moscú es incompleta, presentando una posible laguna estratigráfica en la base de la misma.Palabras clave: Bashkiriense, Moscoviense, base del Moscoviense, Zona Cantábrica, fusulinas.Abstract: The Carboniferous strata embracing the Bashkirian/Moscovian transition of the Cantabrian Zone exhibits a fusuline succession that is not recorded in the Moscow Basin, typearea for the lower Moscovian boundary. The time recorded in this strata interval is interpreted as coinciding with a gap at the base of the Moscovian succession in the Moscow Basin.Keywords: Bashkirian, Moscovian, lower Moscovian boundary, Cantabrian Zone, fusulines.
Aprovechamiento de metano en la cuenca carbonífera central asturiana: trabajos recientes The use of methane in the asturian central coal basin: recent work
Authors: Canto Toimil Noel
Published: November 2018

Resumen: La explotacion de hidrocarburos no convencionales, entre ellos el del metano contenido en las capas de carbón (cbm: Coal Bed Methane), ha experimentado un gran auge en los últimos anos. La Cuenca Carbonífera Central Asturiana (ccca) ofrece un gran potencial para desarrollar proyectos de este tipo, como lo atestiguan las investigaciones y valoraciones llevadas a cabo en esta zona desde los años 90 del siglo xx. Hunosa, la empresa minera estatal que opera actualmente en la ccca, ha realizado una serie de investigaciones en los últimos años encaminadas al estudio de las posibilidades de desarrollar proyectos vinculados al aprovechamiento de metano del carbón, ya sea vam, amm, cmm o cbm. Los resultados obtenidos muestran que el cbm es el tipo de proyecto más adecuado actualmente para desarrollar en la ccca.Palabras clave: carbón, cbm, Cuenca Carbonífera Central Asturiana, hunosa, metano.Abstract: The exploitation of unconventional hydrocarbon deposits has increased in recent years. Methane from coal seams represents one of these gas resources. The Central Asturian Coalfield (cac) has a high potential to develop these types of projects, as many studies and research carried out since the 90’s (20th century) confirm. Hunosa, the stated-owned coal-mining company that currently operates in this area, has performed research for the last years focused on assessing the feasibility of developing projects related to methane exploitation: vam, amm, cmm and cbm. These studies have concluded that cbm projects would be the most adequate technique to be implemented in cac.Keywords: coal, cbm, Central Asturian Coalfield, hunosa, methane.
Enterramientos Infantiles Altomedievales en La Cabilda, Hoyo de Manzanares, Madrid. Early Middle Ages infant burials in La Cabilda, Hoyo de Manzanares, Madrid (Spain)
Authors: Gomez Osuna Rosario
Published: November 2018

Se presentan tres inhumaciones infantiles documentadas en el yacimiento Altomedieval de La Cabilda, Hoyo de Manzanares, Madrid, en la campaña de excavaciones del año 2017. Tienen la peculiaridad de localizarse asociadas a una estructura no funeraria, habitacional y de carácter auxiliar. El yacimiento de La Cabilda es un asentamiento aldeano rural situado en el pie de la Sierra de Guadarrama, con cronologías del siglo VII d.C. Cuenta con 23 estructuras de habitación y productivas, y con enterramientos dispersos en sepulturas excavadas en roca granítica, de tipo ovalado, en las proximidades de los edificios. Para la interpretación de las tumbas infantiles aparecidas y del espacio funerario elegido, se realiza un análisis de datos conocidos sobre este tipo singular de enterramientos y se incluyen ejemplos de inhumaciones infantiles de similar cronología de los yacimientos Altomedievales de la Sierra de Guadarrama.Results of the study of three infant burials located in the Early Middle Ages archaeological site of La Cabilda, Hoyo de Manzanares, Madrid (Spain), as found during the excavation campaign of 2017. The burials have the peculiarity of being linked to an auxiliar dwelling structure, not associated with funerary purposes.The La Cabilda archaeological site, in Hoyo de Manzanares, corresponds to a farming settlement dated in the 7th century CE and located at the hem of Madrid’s Guadarrama Mountain Range. The site is comprised of 23 farming and housing building structures with additional scattered burials, oval-shaped and excavated in granite rock, located in the vicinity of the buildings.In order to interpret the infant burials and their associated funerary area, we perform an analysis of known data on this type of sepultures, including examples of other, similarly dated, infant burials found in Early Middle Ages archaeological sites in the Guadarrama Mountain Range.
Comparative study of outcome following primary posterior sagittal ano-rectoplasty and primary anterior sagittal ano-rectoplasty for vestibular fistula
Authors: Saoji Rajendra , Nagdeve Nilesh G.
Published: November 2018

Background: To compare the postoperative complications and bowel function following primary PSARP and primary ASARP.Methods: This prospective study was carried out over a period of 4 years. Patients above 4 months, who needed surgical repair for vestibular fistula were included in study.  They were randomly allocated into PSARP group and ASARP group. After surgical intervention, patients of both groups were compared with respect to post-operative complications, voluntary bowel control, constipation, need for laxatives.Results: 44 patients were enrolled in the study. Of these, 22 patients were allocated to primary PSARP group while remaining patients underwent ASARP. One patient from each group was lost to follow‑up and hence, excluded from the final analysis. The two groups were comparable with respect to age, maturity at birth, weight at the time of surgery, blood investigations. Total 16 patients had associated congenital anomalies. During the postoperative period, four patients from PSARP group and two patients from ASARP group had superficial wound infection of perineal incision which was managed conservatively. One patient in PSARP group had a major breakdown of perineal wound with retraction of pulled rectum which required colostomy. There was no recurrence of fistula in any patient. No patient had stenosis of neo-anus or anterior displacement of rectum. Functional assessment of bowel function was done in 25 patients who completed 3 years of age. Voluntary bowel movements were observed in 75% of cases in the ASARP group compared to 38 % in PSARP group.  15% patients of PSARP group and 7.5% patients with ASARP had soiling. Though the difference was not statistically significant, nearly 38% of the patients after PSARP, needed laxative for normal bowel habit compared to 8% patients in ASARP group.Conclusions: ASARP promises many advantages in the treatment of vestibular fistula in comparison to PSARP. Comparable post-operative complications, good cosmetic results, excellent continence with less need for laxatives are the advantages of ASARP.
Definitive surgical treatment for diabetic forefoot ulcer
Authors: Rajendran M. K.
Published: November 2018

Background: Diabetic foot ulcers are common among 15% of the diabetic population, at one stage of life that may progress to minor or major amputation, because of not healing with all modalities of the treatment. Since recurrent rate is >90%. But the surgical treatment of the forefoot ulcer so-called surgery offloading will heal the ulcer within a short time and prevent minor of major amputation. The purpose of this study was to compare different outcome measures in the audit of the management of diabetic foot ulcers.Methods: Totally 20 diabetic patients were included in the study. The study was conducted in the department of plastic surgery, Government Mohan Kumaramangalam Medical College Hospital, from 2016-2018. Followed 20 patients with a surgical procedure called surgical offloading is by removing pressure element in head and neck of metatarsal bone involved.Results: Among the 20 patients wound healed, in about 12 patients within 4 to 5 week and its remaining 5 patients wound healed in 5 to 6 weeks are in other 2 patients it takes. More than 6 weeks to heal. We followed the patients for the past 1 year, out of 20 patients, 2 patients have developed an ulcer in another site, not the same site. In all other patients wound healed completely without any recurrence.Conclusions: In our study reducing the foot pressure by doing an excision of head and neck metatarsal surgically will completely remove the foot pressure over the ulcer site that helps to heal the ulcer without recurrence.
Efficacy of nano silver dressings over conventional dressings in chronic wounds
Authors: Suhas K. , Manvi P. Manvi Naga
Published: November 2018

Background: Chronic wounds give rise to serious health problems, accompanied by a decrease in quality of life. Silver has been an effective agent with documented efficacy against wide spectrum of bacterial, viral, and fungal infections. Recently, many silver-based preparations are available for effective management of wounds. Among them silver nano particles, exhibit significantly novel and distinct physical, chemical, and biological properties. Due to their nano scale size, they have been elicited much interest in wound management. This study aims to compare the efficacy of nano silver dressing in chronic wounds with that of conventional dressings.Methods: This was a prospective study conducted in the Department of General Surgery, Alluri Sita Rama Raju Academy of Medical Sciences from August 2017 to August 2018. A total of 100 patients with chronic wounds were included in the study and were equally divided into-Study group and Control group randomly. Swab cultures were sent in all the patients. The study group received nano silver dressings while the controls received daily dressings with normal saline soaked gauges, betadine and hydrogen peroxide. Data regarding the time required for healing, number of days required for healing and percentage of healing are noted.Results: Nano silver dressings in the treatment of chronic wounds are found to be safe, effective, promoter of wound healing, promotes epithelization, accelerates healing, eliminates anaerobes and breaks microbial synergy more effectively than conventional dressing. Hence Nano silver spray prove to be more effective in the management of chronic wounds. In study group, 50% of patients stay for 3-4 weeks whereas in control group, 70% of patients stay for 5-6 weeks. 91-99% reduction in size of ulcer is seen in 43 out of 50 patients in study group whereas in control group only 8 out of 50 shows 91-99% reduction in size.Conclusions: Nano silver dressings is a cost effective option in ulcer management. It decreases the period of hospitalization and reduces the burden on the health care system.
A novel treatment protocol in acute pancreatitis: the first double blinded comparative trial of omega 3 fatty acid infusion versus octreotide
Authors: Rudraiah H. G. M. , Kalke Siddharth Vijay , Desai Aniruddha
Published: November 2018

Background: Over decades the treatment of acute pancreatitis remains debatable with no common consensus on treatment guidelines, with some workers using octreotide infusion and some workers only relying on fluid therapy and symptomatic management. This is the first of its kind double blinded comparative trial between omega 3 fatty acid infusion versus octreotide infusion and its response in cases of acute pancreatitis.: Our aim is to study the efficacy of omega 3 fatty acid infusion and set a new treatment protocol in cases of acute pancreatitis with the use of omega 3 fatty acid infusion in all admitted cases of acute pancreatitis unless otherwise contraindicated.Methods: This is the first study where a doubled blinded randomised control trial was undertaken in proven cases of acute pancreatitis and patients were given omega 3 fatty acid infusion and octreotide infusion and the observations were documented and followed upon.100 cases of proven acute pancreatitis were randomised with double blinded closed envelop method. 50 cases were given omega 3 fatty acid infusion and other 50 were given octreotide infusion and the clinical response, symptomatic improvement was assessed and compared using BISAP and Marshal scoring systems and lipase levels. Chi Square test was used along with unpaired t test and p value was obtained in both groups.Results: Omega 3 fatty acid infusion was found to be highly significant as compared to octreotide in cases of acute pancreatitis in terms of clinical improvement, reduced hospital stay, reversal of organ dysfunction and SIRS.Conclusions: Omega 3 fatty acid infusion is the future in cases of acute pancreatitis which is cheap and easily available with no side effects and reduces the morbidity and mortality in acute pancreatits with reduced hospital stay in turn resulting in overall reduced medical expenditure.
AKILLI CİHAZ KULLANICILARININ MARKA SADAKATLERİNİ ETKİLEYEN FAKTÖRLER ÜZERİNE BİR ARAŞTIRMA
Authors: UZUNKAYA Tuğba , YÜKSELEN Cemal
Published: November 2018

Teknolojinin
hızla gelişmesiyle, akıllı cihazlar daha fonksiyonel ve ayırt edici özelliklere
sahip hale gelmiştir. Özellikle iletişim teknolojisi, her geçen gün daha
yaratıcı yeniliklerle, tüketicilere ürünlerini sunmaktadır. Tüketicileri için akıllı
cihazların ayırt edici özellikleri hakkında bilgilendirmeleri, diğer bir
deyişle marka farkındalığı yaratmaları firmalar için son derece önemlidir.
Ancak marka farkındalığının yaratılması, rekabetin yoğun olarak yaşandığı rekabet
ortamında yeterli değildir. Tüketicilerin zihninde markaya üstünlük katan
algılanan kalite düzeyi arttırılmalı ve olumlu marka bağlılığı yaratılarak
geliştirilmelidir.

Çalışmanın amacı; akıllı
cihaz alımında algılanan kalite, marka farkındalığı ve marka imajının marka
sadakatini olumlu yönde etkileyip etkilemediğini analiz etmektir. Ayrıca bu
etkinin tüketicilerin cinsiyet, yaş grupları, gelir dağılımı ve öğrenim
düzeyine göre farklılık gösterip göstermediği de incelenmiştir.
I Know Why the Caged Bird Sings
Authors: DePass Cecille
Published: November 2018

Call for submissions to a  CPI issue that will explore minority resistance, resilience, and defiance when encountering systemic restrictions and man-made forms of oppression.
Nobilitazione come scelta traduttiva. Il caso di Tre metri sopra il cielo di Federico Moccia nella traduzione polacca
Authors: Sosnowski Roman
Published: November 2018

L’analisi riguarda il romanzo di Tre metri sopra il cielo in italiano e la sua traduzione polacca. Partendo dal differente valore degli indici di ricchezza lessicale nel prototesto e nel testo tradotto viene analizzata la resa in polacco di espressioni stereotipate selezionate con il metodo semiautomatico. L’analisi rivela che alle ripetizioni di Moccia nella traduzione polacca corrispondono piu soluzioni lessicali. In base all’analitica della traduzione di Berman esse vengono interpretate come casi di nobilitazione. Oltre a interpretarlo si cerca di giustificare il ricorso alla nobilitazione nel caso della paraletteratura.
Nietypowe rozwiązania translatorskie w tłumaczeniu tekstu naukowego na przykładzie Nadzorować i karać Michela Foucault
Authors: Masłowska Patrycja
Published: November 2018

Artykuł omawia tłumaczenia wybranej terminologii Nadzorować i karać (tłum. Tadeusz Komendant) Michela Foucault, a także podejmuje charakterystykę pracy jako tekstu naukowego. Ta charakterystyka oraz analizowane pojęcia dowodzą jednak, że tekst naukowy może wykazywać również cechy innych typów tekstów, co dowodzi ich płynności gatunkowej.
Mixed integer programming approach for seasonal anomalies in stock markets: A case study for BIST
Authors: Arik Oguzhan Ahmet
Published: November 2018

This paper proposes a mixed integer programming approach for seasonal anomalies in stock markets and presents a case study for the XU030 index in the stock market of Istanbul Stock Exchange (BIST). Stock markets are significant for economies of countries all over the world. Investors get economical wealth or lose some of their investment by selling and buying stocks. Therefore, buying and selling times of stocks are so important. This paper investigates a well-known effect called as â€˜Sell in May and Go Awayâ€™ by proposing a MIP approach that searches best times for buying and selling of stocks in a year. Furthermore, this paper includes a numerical example of XU030 stock prices for the past 5 years and shows that most of the XU030 stocks have seasonal anomalies.Keywords: First keyword, second keyword, third keyword, forth keyword.
The next frontier: Open innovation and knowledge absorptive capacity in business incubators: Towards the experience from Chile, Israel and Italy
Authors: Martins Oliveira Selma Regina , Trento Sandro
Published: November 2018

This research aims to verify the relationship between the open innovation practices and knowledge absorptive capacity in business incubators from Chile, Israel and Italy. Furthermore, this research examines how this affects the outcomes (business incubators performance). The research was conducted in the light of theoretical excerpts and application of a survey to specialists, with knowledge about the investigated object, selected by scientific and technical criteria. The data were extracted by means of a matrix of judgement in which experts made their judgments about the variables investigated. In order to reduce subjectivity in the results achieved, the following methods were used: multicriterial analysis and neurofuzzy technology. The produced results were satisfactory, validating the presented proposal.Keywords: Open innovation practices, knowledge absorptive capacity, business incubators, business incubators performance, experience from Chile, Israel and Italy.
An approach for sustainable innovation: TRIZ
Authors: Ozkeser Banu
Published: November 2018

TRIZ, a Russian acronym for the Theory of Inventive Problem Solving, is an approach for systematic innovation planning. In the Theory of Inventive Problem Solving (TRIZ), the overall aim is the development of an enhanced methodology for a smooth innovation mapping. It is also a way of technology management. The base of TRIZ depends on organisational ecology and sustainability concepts. Should a foundation use this scientific method, then, sustainable innovation can easily occur there. In this paper, conceptualised combinations will be further investigated, tested and applied in subsequent phases and results. The organization of this paper has four major phases. The first part is composed of general terminology, benefits of the method and rules. The second part gives information about the definition of the problem and the details of the way which is used. Concept of the third phase is about the implementation. The results, comments and recommendations form the last phase.Keywords: TRIZ, sustainability, innovation.
Knowledge transfer requirements for the management of social enterprises and organisations
Authors: Zontek Zbigniew , Whitworth Christopher
Published: November 2018

The authors have extensively researched motivation and situated learning in social organisations and enterprises via qualitative processes. This was an original work in an under-researched area. The use of open interpretative phenomenological analysis allowed an in-depth study of over 30 individualâ€™s motivations and processes. Their findings clearly demonstrate the role of, and need for, knowledge acquisition, restructuring and transfer into new and evolving NGOâ€™s and similar not-for-profit ventures. Study of 10 very different organisations in two European countries revealed common mechanisms for gaining and utilising knowledge in new ways and for new applications. All were Communities of Practice (CoPs) with a well-defined purpose and rationale. Almost all those interviewed reported utilising their knowledge from earlier experiences, in new ways, and situations. This need for internal and external knowledge transfer was stressed by almost all participants, and how they solved it in their CoP forms a key outcome of the research.Keywords: Management, social enterprise, knowledge transfer.
Determination of the effect of information and communication technologies (ICTs) to unit labour cost: G7 countries examples
Authors: Ozturk Serdar , Bicimveren Lutfi
Published: November 2018

Following the realisation of the revolutions in various fields on Earth, the field of information and communication has also been incorporated into these developed fields. Where information and communication technologies (ICTs) are not enough for human power, they are confronted as a field that seizes work, or even accelerates them in practice. The main purpose of this study is to determine whether there is a relationship between investment of ICTs and unit labour costs (ULCs) in the G7 countries between 1990 and 2010. In the study panel, vector autoregressive and Granger Causality tests were applied. As a result of the analysis made, a negative and significant relationship has been determined between the investments made in the ICTs and the ULC.Keywords: ICT, labour cost, causality, relationship.Jel Classification Codes: O3, J2.âˆ—
The inefficiency of the justice in Portugal: Causes and consequences
Authors: Silva N. Jesus
Published: November 2018

Given the breach of trust that the justice system in Portugal is facing, it is fundamental to analyse the reasons why the judicial system is considered inefficient. This study contributes to the identification of the underlying factors that contribute most to the inefficiency of justice in Portugal by analysing the frequency of the most relevant contents enunciated by the participants. The survey consists of two parts: the first consists of the following socio-demographic variables: occupation, region, age, gender and remuneration; the second consists of an open question, to which participants can state which factors contribute most to the ineffectiveness of justice in Portugal. The answers obtained were submitted to a content analysis with the aim of identifying the content underlying the inefficiency of justice in Portugal, with 18 subcategories emerging according to the contents expressed by the participants. In this way, the way above all of simplification, justice will go to what really matters: efficiency, celerity and transparency.Keywords: Justice, inefficiency, transparency, judicial systems
Estimating the maximal oxygen uptake with new prediction models for college-aged students using feature selection algorithm
Authors: Akay Mehmet Fatih , Ozciloglu Mustafa Mikail , Cetin Ebru , Yarim Imdat , Daneshvar Shahaboddin
Published: November 2018

Maximum oxygen consumption (VO2max) is important to observe the endurance of the athletes and evaluate their performance.. Aim is to develop new prediction models for college-aged students using Support Vector Machine (SVM) with Relief-F feature selection algorithm. Ten different models consisting of the predictor variables gender, age, weight, height, maximal heart rate (HRmax), time, speed, Perceived Functional Ability scores (PFA-1 and PFA-2) and Physical Activity Rating score (PA-R) have been created by Relief-F scores for prediction of VO2max. The prediction modelsâ€™ standard error of estimates (SEEâ€™s) and multiple correlation coefficients (Râ€™s) have been calculated for evaluating their performances. For comparison purposes, Tree Boost (TB) and Radial Basis Function Network (RBFN) based models have also been developed. The results show that the prediction model including PAR, speed, time, weight, PFA-1, gender and HRmax gives the lowest SEE with 6.42 mL.kgâˆ’1.minâˆ’1 and highest R with 0.79. Also, this study shows that the predictor variables HRmax and gender play a considerable role in VO2max prediction.

Keywords: Maximum oxygen uptake, machine learning, feature selection.
The possible reasons for misunderstanding the meanings of puns in the Holy Quran from Arabic into English
Authors: Al Aqad Mohammed H. , Thabet Ahmad Thabet Ahmad , Bin Sapar Ahmad Arifin , Hussin Mohammad Bin , Mokhtar Ros Aiza Mohd , Mohad Abd Hakim
Published: November 2018

Translation of the Qurâ€™an is still a problematic issue for each translator in the Islamic theology, because the Quran has numerous Islamic terms/words that hold multiple or double meanings, which cause problems in translation. These problems are due to the dissimilar translations of puns (tawriyah) and the misinterpretations between the intended meanings of puns with their inherent notions, which could result in a certain amount of ambiguity. and end up translating in superficial sense. This research deals with the challenges of translating the meanings of puns (tawriyah) from the Quran into English. The research corpus is based on several verses (Ayat) selected from the Holy Quran. The objectives of the study are to determine the types of English puns in the Quranic text to identify causes for misunderstanding the meanings of puns in the Holy Quran from Arabic into English.Keywords: The Holy Quran, puns misunderstanding, delabastita strategies, reasons for misinterpreting the Quran.
A case study of evaluation and introduction of â€˜An Ecomodernist Manifestoâ€™ by John Asafu-Adjaye et al. in ESP classes
Authors: Nigmatzyanova Yulia , Valeeva Nailya , Guslyakova Alla , Merkushina Natalia
Published: November 2018

The paper presents the experience of the Department of Foreign Languages, Ecological Faculty, RUDN University, in teaching English for specific purposes (ESP). A case study of the introduction of â€˜An Ecomodernist Manifestoâ€™ in ESP classes is discussed in the article. â€˜An Ecomodernist Manifestoâ€™ is a 25-page essay written by 18 environmental scientists, activists and scholars. The present study is an attempt to consider the value of the manifesto for teaching English to upper-intermediate and advanced students of environmental studies faculties. It is found that the manifesto can serve this purpose in terms of its content and language. Implementation of the manifesto in ESP courses has positive aspects as well as challenges outlined in the conclusion. Taking into account the obtained results, the manifesto can be recommended for students with upper-intermediate and advanced levels of language proficiency. This study might be interesting for teachers of foreign languages and contribute to the field of didactics.Keywords: Teaching and studying foreign languages, English for specific purposes (ESP), teaching material, case study.
Impact of ecologic education and values on pupilsâ€™ ecologic consciousness
Authors: Jancius Rutenis , Vaznoniene Gintare , Gavenauskas Algirdas , Pekarskas Juozas
Published: November 2018

Ecological challenges encourage thinking about the quality of education, the need to develop a person who is responsible and able to live in harmony with the environment and is distinguished by ecological competences. The purpose of the research is to identify the ecological consciousness of pupils and values of pupils, which are developed based on the â€˜Concept of the development of ecology and environmental technologiesâ€™. For the purpose of the research, a case study was applied, a quantitative research was carried outâ€”the first school in Lithuania was analysed, where the concept of ecology and environmental technology development has been implemented since 2015. The research involved 11thand 12th grade pupils (N = 80). The results of the research were analysed using descriptive statistics, factor analysis, correlation analysis and comparison method.Keywords: Ecologic education, pupils, values, ecologic consciousness
A comparison with the competencies of English language teaching program
Authors: Cinar Saadet , Babadogan Mustafa Cem
Published: November 2018

In this study, the competencies of the Undergraduate English Language Teaching Programmes belonging to the universities selected as samples from seven regions of our country were examined by using the document analysis method. It has been understood that the concepts of â€˜knowledgeâ€™, â€˜skillâ€™ and â€˜competenceâ€™ which are the components of the â€˜competencyâ€™ concept as well as differences in the expression are not fully distinguishable. It was also observed that while the competencies were being written, universities did not adopt the same grammatical rules. In this study, arrangements were made with the focus was on providing a common framework both conceptually and formally, and suggestions were tried to be developed. It is thought that this work will be useful for programmes that have difficulty in expressing their competencies correctly.Keywords: Bologna process, English language teaching programme, competency.
A comparison with English language and literature department programme competencies
Authors: Kizil Figen , Babadogan Mustafa Cem
Published: November 2018

The idea of establishing the European Higher Education Area (EHEA), aiming to establish a balance between diversity and unity among higher education institutions, started with the Sorbonne Declaration, first published in 1998.The EHEA seeks to ensure that higher education systems are compatible and comparable to one another while preserving their unique differences. This study is aimed to examine the programme competencies of the Department of English Language and Literature. To represent the universe, a state university offering education in English Language and Literature from Turkeyâ€™s seven regions are chosen, aimed to create a common language for writing the competencies and correct the existing programme competencies. In order to bring the programmes together on a common ground and to be recognised both nationally and internationally, it is important to ensure that the programme competencies are written in a more simplified way without creating comorbidity and classified in the right sub-categories. The study was carried out with case studies from qualitative research methods.Keywords: European Higher Education Area, Bologna process, Bologna information system, competence.