bluuebunny/crossref_metadata_2025 huggingface dataset:
Prospects of Polymeric Nanofibers Loaded with Essential Oils for Biomedical and Food-Packaging Applications
Authors: Rather Anjum Hamid , Wani Taha Umair , Khan Rumysa Saleem , Pant Bishweshwar , Park Mira , Sheikh Faheem A.
Published: April 2021

Essential oils prevent superbug formation, which is mainly caused by the continuous use of synthetic drugs. This is a significant threat to health, the environment, and food safety. Plant extracts in the form of essential oils are good enough to destroy pests and fight bacterial infections in animals and humans. In this review article, different essential oils containing polymeric nanofibers fabricated by electrospinning are reviewed. These nanofibers containing essential oils have shown applications in biomedical applications and as food-packaging materials. This approach of delivering essential oils in nanoformulations has attracted considerable attention in the scientific community due to its low price, a considerable ratio of surface area to volume, versatility, and high yield. It is observed that the resulting nanofibers possess antimicrobial, anti-inflammatory, and antioxidant properties. Therefore, they can reduce the use of toxic synthetic drugs that are utilized in the cosmetics, medicine, and food industries. These nanofibers increase barrier properties against light, oxygen, and heat, thereby protecting and preserving the food from oxidative damage. Moreover, the nanofibers discussed are introduced with naturally derived chemical compounds in a controlled manner, which simultaneously prevents their degradation. The nanofibers loaded with different essential oils demonstrate an ability to increase the shelf-life of various food products while using them as active packaging materials.
Eigenfrequency-Based Bayesian Approach for Damage Identification in Catenary Poles
Authors: Alkam Feras , Lahmer Tom
Published: April 2021

This study proposes an efficient Bayesian, frequency-based damage identification approach to identify damages in cantilever structures with an acceptable error rate, even at high noise levels. The catenary poles of electric high-speed train systems were selected as a realistic case study to cover the objectives of this study. Compared to other frequency-based damage detection approaches described in the literature, the proposed approach is efficiently able to detect damages in cantilever structures to higher levels of damage detection, namely identifying both the damage location and severity using a low-cost structural health monitoring (SHM) system with a limited number of sensors; for example, accelerometers. The integration of Bayesian inference, as a stochastic framework, in the proposed approach, makes it possible to utilize the benefit of data fusion in merging the informative data from multiple damage features, which increases the quality and accuracy of the results. The findings provide the decision-maker with the information required to manage the maintenance, repair, or replacement procedures.
The Fate of Deroceras reticulatum Following Metaldehyde Poisoning
Authors: Campbell Amy , Audsley Neil , Port Gordon
Published: April 2021

The concentration of a pesticide used in agriculture not only has implications for effectiveness of pest control but may also have significant wider environmental consequences. This research explores the acceptability of metaldehyde slug pellets at different concentrations by Deroceras reticulatum (Müller, 1774) (Agriolimacidae), and the changes in the health status of the slug when allowed to recover. The highest metaldehyde concentration (5%) yielded the highest slug mortality; however, it also produced the highest proportion of unpoisoned slugs, suggesting the highest level of pellet rejection. Pellets with 1% metaldehyde were as effective as 3% pellets in paralysing a significant proportion of the population after initial pellet exposure; however, more slugs were able to recover from metaldehyde poisoning at 1% metaldehyde compared with 3%. There was no statistically significant difference between the mortality rate of slugs regardless of metaldehyde concentration, suggesting that a lower concentration of metaldehyde may be as effective as a higher concentration.
The Insect Pest Control Laboratory of the Joint FAO/IAEA Programme: Ten Years (2010–2020) of Research and Development, Achievements and Challenges in Support of the Sterile Insect Technique
Authors: Vreysen Marc J. B. , Abd-Alla Adly M. M. , Bourtzis Kostas , Bouyer Jeremy , Caceres Carlos , de Beer Chantel , Oliveira Carvalho Danilo , Maiga Hamidou , Mamai Wadaka , Nikolouli Katerina , Yamada Hanano , Pereira Rui
Published: April 2021

The Joint FAO/IAEA Centre (formerly called Division) of Nuclear Techniques in Food and Agriculture was established in 1964 and its accompanying laboratories in 1961. One of its subprograms deals with insect pest control, and has the mandate to develop and implement the sterile insect technique (SIT) for selected key insect pests, with the goal of reducing the use of insecticides, reducing animal and crop losses, protecting the environment, facilitating international trade in agricultural commodities and improving human health. Since its inception, the Insect Pest Control Laboratory (IPCL) (formerly named Entomology Unit) has been implementing research in relation to the development of the SIT package for insect pests of crops, livestock and human health. This paper provides a review of research carried out between 2010 and 2020 at the IPCL. Research on plant pests has focused on the development of genetic sexing strains, characterizing and assessing the performance of these strains (e.g., Ceratitis capitata), elucidation of the taxonomic status of several members of the Bactrocera dorsalis and Anastrepha fraterculus complexes, the use of microbiota as probiotics, genomics, supplements to improve the performance of the reared insects, and the development of the SIT package for fruit fly species such as Bactrocera oleae and Drosophila suzukii. Research on livestock pests has focused on colony maintenance and establishment, tsetse symbionts and pathogens, sex separation, morphology, sterile male quality, radiation biology, mating behavior and transportation and release systems. Research with human disease vectors has focused on the development of genetic sexing strains (Anopheles arabiensis, Aedes aegypti and Aedes albopictus), the development of a more cost-effective larvae and adult rearing system, assessing various aspects of radiation biology, characterizing symbionts and pathogens, studying mating behavior and the development of quality control procedures, and handling and release methods. During the review period, 13 coordinated research projects (CRPs) were completed and six are still being implemented. At the end of each CRP, the results were published in a special issue of a peer-reviewed journal. The review concludes with an overview of future challenges, such as the need to adhere to a phased conditional approach for the implementation of operational SIT programs, the need to make the SIT more cost effective, to respond with demand driven research to solve the problems faced by the operational SIT programs and the use of the SIT to address a multitude of exotic species that are being introduced, due to globalization, and established in areas where they could not survive before, due to climate change.
A Non-Invasive Photonics-Based Device for Monitoring of Diabetic Foot Ulcers: Architectural/Sensorial Components & Technical Specifications
Authors: Doulamis Anastasios , Doulamis Nikolaos , Angeli Aikaterini , Lazaris Andreas , Luthman Siri , Jayapala Murali , Silbernagel Günther , Napp Adriane , Lazarou Ioannis , Karalis Alexandros , Hoveling Richelle , Terzopoulos Panagiotis , Yamas Athanasios , Georgiadis Panagiotis , Maulini Richard , Muller Antoine
Published: April 2021

This paper proposes a new photonic-based non-invasive device for managing of Diabetic Foot Ulcers (DFUs) for people suffering from diabetes. DFUs are one of the main severe complications of diabetes, which may lead to major disabilities, such as foot amputation, or even to the death. The proposed device exploits hyperspectral (HSI) and thermal imaging to measure the status of an ulcer, in contrast to the current practice where invasive biopsies are often applied. In particular, these two photonic-based imaging techniques can estimate the biomarkers of oxyhaemoglobin (HbO2) and deoxyhaemoglobin (Hb), through which the Peripheral Oxygen Saturation (SpO2) and Tissue Oxygen Saturation (StO2) is computed. These factors are very important for the early prediction and prognosis of a DFU. The device is implemented at two editions: the in-home edition suitable for patients and the PRO (professional) edition for the medical staff. The latter is equipped with active photonic tools, such as tuneable diodes, to permit detailed diagnosis and treatment of an ulcer and its progress. The device is enriched with embedding signal processing tools for noise removal and enhancing pixel accuracy using super resolution schemes. In addition, a machine learning framework is adopted, through deep learning structures, to assist the doctors and the patients in understanding the effect of the biomarkers on DFU. The device is to be validated at large scales at three European hospitals (Charité–University Hospital in Berlin, Germany; Attikon in Athens, Greece, and Victor Babes in Timisoara, Romania) for its efficiency and performance.
The Impact of COVID-19 Pandemic on Children with Pulmonary Arterial Hypertension. Parental Anxiety and Attitudes. Follow-Up Data from the Polish Registry of Pulmonary Hypertension (BNP-PL)
Authors: Kwiatkowska Joanna , Meyer-Szary Jaroslaw , Mazurek-Kula Anna , Zuk Malgorzata , Migdal Anna , Kusa Jacek , Skiba Elzbieta , Zygielo Karolina , Przetocka Kinga , Kordon Zbigniew , Banaszak Pawel , Michalczyk Agata , Rzeznik-Bieniaszewska Alina , Surmacz Rafal , Bobkowski Waldemar , Wojcicka-Urbanska Barbara , Werner Bozena , Pluzanska Joanna , Ostrowska Katarzyna , Bazgier Magdalena , Kopec Grzegorz
Published: April 2021

The COVID-19 pandemic has impacted healthcare systems worldwide. Little is known about the impact of the pandemic on medical and psycho-social aspects of children with rare diseases such as pulmonary arterial hypertension and their parents. The study is based on children registered in The Database of Pulmonary Hypertension in the Polish Population and a parent-reported survey deployed during the first 6 months of the pandemic. The questionnaire consisted of six question panels: demographic data, fear of COVID-19, General Anxiety Disorder-7 (GAD-7), social impact of pandemic, patients’ medical status, and alarming symptoms (appearance or exacerbation). Out of 80 children registered, we collected 58 responses (72.5% response rate). Responders (parents) were mostly female (n = 55; 94.8%) at a mean age of 40.6 ± 6.9 years. Patients (children) were both females (n = 32; 55%) and males with a mean age of 10.0 ± 5.1 years. Eleven (19%) children had symptoms of potential disease exacerbation. Eight parents (72.7%) decided for watchful waiting while others contacted their GPs or cardiologists (n = 6; 54.5%). Three children had to be hospitalized (27.3%). Most planned hospitalizations (27/48; 56.2%) and out-patient visits (20/35; 57.1%) were cancelled, delayed, or substituted by telehealth services. Among the participating parents, the study shows very high levels of anxiety (n = 20; 34.5%) and concern (n = 55; 94.8%) and the need for detailed information (52; 89.6%) regarding COVID-19 and medical service preparedness during the pandemic. The COVID-19 pandemic has influenced child healthcare and caused high levels of anxiety among parents.
Influence of Age on Postoperative Neurological Outcomes after Surgery of Acute Type A Aortic Dissection
Authors: Salem Mohamed , Salib Michael , Friedrich Christine , Salem Mostafa , Puehler Thomas , Schoettler Jan , Schoeneich Felix , Cremer Jochen , Haneya Assad
Published: April 2021

Background: Acute type A aortic dissection (AAAD) is considered a fatal disease which requires an emergent surgical intervention. This study focuses onthe neurological outcome after surgical repair in cases of AAAD in comparison between elderly and young patients. Methods: a retrospective analysis of 368 consecutive patients who underwent emergency surgery of ascending aorta in moderate hypothermic circulatory arrest (MHCA) (20–24 °C) and antegrade cerebral perfusion after AAAD between 2001 and 2016. Patients were divided into two groups: those aged 75 years and older (68 (18.5%)) and those younger than 75 years (300 (81.5%)). Results: Comparing both groups, average age was 79.0 ± 3.2 vs. 59.2 ± 10.7 years (p < 0.001); female gender represents 58.8% of elderly patients vs. 28.7% in younger patients (p < 0.001). Intraoperatively, cardiopulmonary bypass time (155 min (131; 187) vs. 171 min (137; 220); p = 0.012), cross-clamping time (79 min (60; 105) vs. 93 min (71; 134); p = 0.001] and circulatory arrest time (29 min (22; 40) vs. 33 min (26; 49); p = 0.011) were significantly shorter in elderly than younger group. Postoperatively, there was no significant difference in delirium (11.8% vs. 20.5%; p = 0.0968) or stroke (11.8% vs. 16.1%; p = 0.369). The 30-day mortality was satisfactory for both groups but significantly higher in the elderly group (27.9% vs. 14.3%; p = 0.007). Conclusion: The current study concluded that surgical treatment of AAAD in elderly patients can be applied safely without increasing risk of neurological complication. However, minimizing operation time may help limit the occurrence of postoperative neurological complication.
[18F]fluoro-ethylcholine-PET Plus 4D-CT (FEC-PET-CT): A Break-Through Tool to Localize the “Negative” Parathyroid Adenoma. One Year Follow Up Results Involving 170 Patients
Authors: Smaxwil Constantin , Aschoff Philip , Reischl Gerald , Busch Mirjam , Wagner Joachim , Altmeier Julia , Ploner Oswald , Zielke Andreas
Published: April 2021

Background: The diagnostic performance of [18F]fluoro-ethylcholine-PET-CT&4D-CT (FEC-PET&4D-CT) to identify parathyroid adenomas (PA) was analyzed when ultrasound (US) or MIBI-Scan (MS) failed to localize. Postsurgical one year follow-up data are presented. Methods: Patients in whom US and MS delivered either incongruent or entirely negative findings were subjected to FEC-PET&4D-CT and cases from July 2017 to June 2020 were analyzed, retrospectively. Cervical exploration with intraoperative PTH-monitoring (IO-PTH) was performed. Imaging results were correlated to intraoperative findings, and short term and one year postoperative follow-up data. Results: From July 2017 to June 2020 in 171 FEC-PET&4D-CTs 159 (92.9%) PAs were suggested. 147 patients already had surgery, FEC-PET&4D-CT accurately localized in 141; false neg. 4, false pos. 2, global sensitivity 0.97; accuracy 0.96, PPV 0.99. All of the 117 patients that already have completed their 12-month postoperative follow up had normal biochemical parameter, i.e., no signs of persisting disease. However, two cases may have a potential for recurrent disease, for a cure rate of at least 98.3%. Conclusion: FEC-PET&4D-CT shows unprecedented results regarding the accuracy localizing PAs. The one-year-follow-up data demonstrate a high cure rate. We, therefore, suggest FEC-PET-CT as the relevant diagnostic tool for the localization of PAs when US fails to localize PA, especially after previous surgery to the neck.
Hot Topics on Fertility Preservation for Women and Girls—Current Research, Knowledge Gaps, and Future Possibilities
Authors: Rodriguez-Wallberg Kenny A. , Hao Xia , Marklund Anna , Johansen Gry , Borgström Birgit , Lundberg Frida E.
Published: April 2021

Fertility preservation is a novel clinical discipline aiming to protect the fertility potential of young adults and children at risk of infertility. The field is evolving quickly, enriched by advances in assisted reproductive technologies and cryopreservation methods, in addition to surgical developments. The best-characterized target group for fertility preservation is the patient population diagnosed with cancer at a young age since the bulk of the data indicates that the gonadotoxicity inherent to most cancer treatments induces iatrogenic infertility. Since improvements in cancer therapy have resulted in increasing numbers of long-term survivors, survivorship issues and the negative impact of infertility on the quality of life have come to the front line. These facts are reflected in an increasing number of scientific publications referring to clinical medicine and research in the field of fertility preservation. Cryopreservation of gametes, embryos, and gonadal tissue has achieved quality standards for clinical use, with the retrieval of gonadal tissue for cryopreservation being currently the only method feasible in prepubertal children. Additionally, the indications for fertility preservation beyond cancer are also increasing since a number of benign diseases and chronic conditions either require gonadotoxic treatments or are associated with premature follicle depletion. There are many remaining challenges, and current research encompasses clinical health care and caring sciences, ethics, societal, epidemiological, experimental studies, etc.
Admission High-Sensitive Cardiac Troponin T Level Increase Is Independently Associated with Higher Mortality in Critically Ill Patients with COVID-19: A Multicenter Study
Authors: Larcher Romaric , Besnard Noemie , Akouz Aziz , Rabier Emmanuelle , Teule Lauranne , Vandercamere Thomas , Zozor Samuel , Amalric Matthieu , Benomar Racim , Brunot Vincent , Corne Philippe , Barbot Olivier , Dupuy Anne-Marie , Cristol Jean-Paul , Klouche Kada
Published: April 2021

Background: In coronavirus disease 2019 (COVID-19) patients, increases in high-sensitive cardiac troponin T (hs-cTnT) have been reported to be associated with worse outcomes. In the critically ill, the prognostic value of hs-cTnT, however, remains to be assessed given that most previous studies have involved a case mix of non- and severely ill COVID-19 patients. Methods: We conducted, from March to May 2020, in three French intensive care units (ICUs), a multicenter retrospective cohort study to assess in-hospital mortality predictability of hs-cTnT levels in COVID-19 patients. Results: 111 laboratory-confirmed COVID-19 patients (68% of male, median age 67 (58–75) years old) were included. At ICU admission, the median Charlson Index, Simplified Acute Physiology Score II, and PaO2/FiO2 were at 3 (2–5), 37 (27–48), and 140 (98–154), respectively, and the median hs-cTnT serum levels were at 16.0 (10.1–31.9) ng/L. Seventy-five patients (68%) were mechanically ventilated, 41 (37%) were treated with norepinephrine, and 17 (15%) underwent renal replacement therapy. In-hospital mortality was 29% (32/111) and was independently associated with lower PaO2/FiO2 and higher hs-cTnT serum levels. Conclusions: At ICU admission, besides PaO2/FiO2, hs-cTnT levels may allow early risk stratification and triage in critically ill COVID-19 patients.
Flexible Modeling of Net Survival and Cure by AML Subtype and Age: A French Population-Based Study from FRANCIM
Authors: Mounier Morgane , Romain Gaëlle , Callanan Mary , Alla Akoua Denise , Boussari Olayidé , Maynadié Marc , Colonna Marc , Jooste Valérie
Published: April 2021

With improvements in acute myeloid leukemia (AML) diagnosis and treatment, more patients are surviving for longer periods. A French population of 9453 AML patients aged ≥15 years diagnosed from 1995 to 2015 was studied to quantify the proportion cured (P), time to cure (TTC) and median survival of patients who are not cured (MedS). Net survival (NS) was estimated using a flexible model adjusted for age and sex in sixteen AML subtypes. When cure assumption was acceptable, the flexible cure model was used to estimate P, TTC and MedS for the uncured patients. The 5-year NS varied from 68% to 9% in men and from 77% to 11% in women in acute promyelocytic leukemia (AML-APL) and in therapy-related AML (t-AML), respectively. Major age-differenced survival was observed for patients with a diagnosis of AML with recurrent cytogenetic abnormalities. A poorer survival in younger patients was found in t-AML and AML with minimal differentiation. An atypical survival profile was found for acute myelomonocytic leukemia and AML without maturation in both sexes and for AML not otherwise specified (only for men) according to age, with a better prognosis for middle-aged compared to younger patients. Sex disparity regarding survival was observed in younger patients with t-AML diagnosed at 25 years of age (+28% at 5 years in men compared to women) and in AML with minimal differentiation (+23% at 5 years in women compared to men). All AML subtypes included an age group for which the assumption of cure was acceptable, although P varied from 90% in younger women with AML-APL to 3% in older men with acute monoblastic and monocytic leukemia. Increased P was associated with shorter TTC. A sizeable proportion of AML patients do not achieve cure, and MedS for these did not exceed 23 months. We identify AML subsets where cure assumption is negative, thus pointing to priority areas for future research efforts.
Evidence-Based Aerobic Exercise Training in Metabolic-Associated Fatty Liver Disease: Systematic Review with Meta-Analysis
Authors: Słomko Joanna , Zalewska Marta , Niemiro Wojciech , Kujawski Sławomir , Słupski Maciej , Januszko-Giergielewicz Beata , Zawadka-Kunikowska Monika , Newton Julia , Hodges Lynette , Kubica Jacek , Zalewski Paweł
Published: April 2021

Background: This meta-analysis evaluates the overall effect of the non-pharmacological intervention, aerobic exercise, upon serum liver enzymes levels, glucose metabolism and anthropometric measures amongst patients with metabolic associated fatty liver disease (MAFLD). It also examines whether the effects on these outcomes are moderated by the aerobic training protocol when considered according to the American College of Sports Medicine (ACSM) recommended FITT (frequency, intensity, time, type) principles. Approach and Results: Fifteen randomized control trials were included in the meta-analysis. Compared with usual care, continuous and interval training showed significant efficacy in alanine aminotransferase (ALT) level improvement (MD = −2.4, 95% CI: −4.34 to −0.46 p = 0.015, I2 = 9.1%). Interventions based on all types of aerobic exercise protocols showed significant improvement of intrahepatic triglycerides (MD = −4.0557, 95% CI: −5.3711 to −2.7403, p < 0.0001, I2 = 0%) and BMI (MD = −0.9774, 95% CI: −1.4086 to −0.5462, p < 0.0001, I2 = 0). Meta-regression analysis demonstrated a significant correlation between total intervention time and ALT level (for all aerobic protocols: 6.0056, se = 2.6896, z = 2.2329, p = 0.02; as well as for continuous and interval aerobic protocols: 5.5069, se = 2.7315, z = 2.016, p = 0.04). Conclusions: All types of aerobic exercise protocols are effective at improving intrahepatic triglycerides and lead to a reduction in body mass index. In addition, continuous and interval aerobic exercise may be more effective at improving ALT ≤12 weeks intervention time benefits the management of MAFLD.
Epidemiology of Primary Epithelial Salivary Gland Tumors in Southern Poland—A 26-Year, Clinicopathologic, Retrospective Analysis
Authors: Gontarz Michał , Bargiel Jakub , Gąsiorowski Krzysztof , Marecik Tomasz , Szczurowski Paweł , Zapała Jan , Wyszyńska-Pawelec Grażyna
Published: April 2021

(1) Background: Epidemiological studies of epithelial salivary gland neoplasms are difficult to conduct effectively due to tumor rarity, histological heterogeneity, tumor location diversity, and a lack of national registries collecting data. This study presents 26 years of epidemiological data from a single institution in southern Poland that estimates incidence rates of primary epithelial salivary gland tumors. (2) Methods: The charts of 805 patients with epithelial salivary gland tumors were retrospectively reviewed. (3) Results: Pleomorphic adenomas occurred less frequently in elderly patients; however, Warthin tumors were more common (p < 0.001). Pediatric patients mainly suffered from mucoepidermoid carcinoma. The estimated crude and European age-standardized incidence rates of all primary epithelial salivary gland tumors were 6.7 and 6.02 per 100,000 population, respectively. The incidence rates of salivary gland tumors increased in recent years; however, this is attributed to an increase in benign tumors (p < 0.001). (4) Conclusions: The incidence of primary epithelial salivary gland tumors in southern Poland has increased over the past 26 years. This increase is attributed to a rise in the number of patients with benign tumors, particularly Warthin tumors in elderly patients. Moreover, the incidence of malignant salivary gland tumors appears to be higher in pediatric patients.
Comorbidities and Susceptibility to COVID-19: A Generalized Gene Set Data Mining Approach
Authors: Beckman Micaela F. , Mougeot Farah Bahrani , Mougeot Jean-Luc C.
Published: April 2021

The COVID-19 pandemic has led to over 2.26 million deaths for almost 104 million confirmed cases worldwide, as of 4 February 2021 (WHO). Risk factors include pre-existing conditions such as cancer, cardiovascular disease, diabetes, and obesity. Although several vaccines have been deployed, there are few alternative anti-viral treatments available in the case of reduced or non-existent vaccine protection. Adopting a long-term holistic approach to cope with the COVID-19 pandemic appears critical with the emergence of novel and more infectious SARS-CoV-2 variants. Our objective was to identify comorbidity-associated single nucleotide polymorphisms (SNPs), potentially conferring increased susceptibility to SARS-CoV-2 infection using a computational meta-analysis approach. SNP datasets were downloaded from a publicly available genome-wide association studies (GWAS) catalog for 141 of 258 candidate COVID-19 comorbidities. Gene-level SNP analysis was performed to identify significant pathways by using the program MAGMA. An SNP annotation program was used to analyze MAGMA-identified genes. Differential gene expression was determined for significant genes across 30 general tissue types using the Functional and Annotation Mapping of GWAS online tool GENE2FUNC. COVID-19 comorbidities (n = 22) from six disease categories were found to have significant associated pathways, validated by Q–Q plots (p < 0.05). Protein–protein interactions of significant (p < 0.05) differentially expressed genes were visualized with the STRING program. Gene interaction networks were found to be relevant to SARS and influenza pathogenesis. In conclusion, we were able to identify the pathways potentially affected by or affecting SARS-CoV-2 infection in underlying medical conditions likely to confer susceptibility and/or the severity of COVID-19. Our findings have implications in future COVID-19 experimental research and treatment development.
Prognostic Value of Bioactive Adrenomedullin in Critically Ill Patients with COVID-19 in Germany: An Observational Cohort Study
Authors: Simon Tim-Philipp , Stoppe Christian , Breuer Thomas , Stiehler Lara , Dreher Michael , Kersten Alexander , Kluge Stefan , Karakas Mahir , Zechendorf Elisabeth , Marx Gernot , Martin Lukas
Published: April 2021

The coronavirus disease 2019 (COVID-19) pandemic has placed a significant burden on hospitals worldwide. Objective biomarkers for early risk stratification and clinical management are still lacking. The aim of this work was to determine whether bioactive adrenomedullin can assist in the risk stratification and clinical management of critically ill COVID-19 patients. Fifty-three patients with confirmed COVID-19 were included in this prospective observational cohort study between March and April 2020. Bioactive adrenomedullin (bio-ADM) plasma concentration was measured daily for seven days after admission. The prognostic value and clinical significance of bio-ADM plasma levels were evaluated for the severity of respiratory failure, the need for extracorporeal organ support and outcome (28-day mortality). Bio-ADM levels increased with the severity of acute respiratory distress syndrome (ARDS; p < 0.001) and were significantly elevated in invasively ventilated patients (p = 0.006) and patients in need of extracorporeal membrane oxygenation (p = 0.040) or renal replacement therapy (RRT; p < 0.001) compared to patients without these conditions. Non-survivors showed significantly higher bio-ADM levels than survivors (p = 0.010). Bio-ADM levels predicted 28-day mortality (C-index 0.72, 95% confidence interval 0.56–0.87, p < 0.001). Bio-ADM plasma levels correlate with disease severity, the need for extracorporeal organ assistance, and outcome, and highlight the promising value of bio-ADM in the early risk stratification and management of patients with COVID-19.
Cardiovascular Calcification as a Marker of Increased Cardiovascular Risk and a Surrogate for Subclinical Atherosclerosis: Role of Echocardiography
Authors: Faggiano Andrea , Santangelo Gloria , Carugo Stefano , Pressman Gregg , Picano Eugenio , Faggiano Pompilio
Published: April 2021

The risk prediction of future cardiovascular events is mainly based on conventional risk factor assessment by validated algorithms, such as the Framingham Risk Score, the Pooled Cohort Equations and the European SCORE Risk Charts. The identification of subclinical atherosclerosis has emerged as a promising tool to refine the individual cardiovascular risk identified by these models, to prognostic stratify asymptomatic individuals and to implement preventive strategies. Several imaging modalities have been proposed for the identification of subclinical organ damage, the main ones being coronary artery calcification scanning by cardiac computed tomography and the two-dimensional ultrasound evaluation of carotid arteries. In this context, echocardiography offers an assessment of cardiac calcifications at different sites, such as the mitral apparatus (including annulus, leaflets and papillary muscles), aortic valve and ascending aorta, findings that are associated with the clinical manifestation of atherosclerotic disease and are predictive of future cardiovascular events. The aim of this paper is to summarize the available evidence on clinical implications of cardiac calcification, review studies that propose semiquantitative ultrasound assessments of cardiac calcifications and evaluate the potential of ultrasound calcium scores for risk stratification and prevention of clinical events.
Personalized Biomechanical Analysis of the Mandible Teeth Behavior in the Treatment of Masticatory Muscles Parafunction
Authors: Gribov Denis , Antonik Mikhail , Butkov Denis , Stepanov Alexandr , Antonik Pavel , Kharakh Yaser , Pivovarov Anton , Arutyunov Sergey
Published: April 2021

A 3D finite element model of the mandible dentition was developed, including 14 teeth, a periodontal ligament (PDL), and a splint made of polymethylmethacrylate (PMMA). The study considered three design options: 1—the case of splint absence; 2—the case of the splint presence installed after manufacture; and 3—the case of splint presence installed after correction (grinding) performed to ensure a uniform distribution of occlusal force between the teeth. For cases of absence and presence of splint, three measurements of the functional load were performed using the T-Scan III software and hardware complex (TekScan, Boston, MA, USA). It was found that the presence of a splint led to a decrease in the total value of the occlusive load and to a uniform distribution between all the mandible teeth. The occlusal force was considered as a static vertical force evenly distributed between the nodes belonging to the occlusive surface of the corresponding tooth for the first design option and the occlusal surface of the splint for the second and third ones, respectively. As a result of the study, it was concluded that the splint usage was effective in order to change the distribution of the functional load during the treatment of proved masticatory muscles’ parafunction; the safety of using a splint for teeth and surrounding tissues under the influence of the considered functional load was shown; the potential applicability of PMMA as a structural material of a splint that had been used for the treatment of masticatory muscles’ parafunction was established.
Further Development of Wear Calculation and Wear Reduction in Cold Forging Processes
Authors: Behrens Bernd-Arno , Brunotte Kai , Hübner Sven , Wester Hendrik , Müller Felix , Müller Philipp , Wälder Jonas , Matthias Tim
Published: April 2021

Tools are of strategic importance for industrial manufacturing processes. Their behaviour has a great influence on the productivity of the process and the quality of the product. A material saving and efficient technique for processing metallic workpieces is cold forging. One major challenge of this production method is the handling of high contact normal stresses in the tool contact, which can lead to severe tool wear. To investigate promising approaches for understanding wear modelling and wear reduction a demonstrator process based on the first stage of a total five-staged cold forging process for the manufacturing of a bolt anchor is considered in the scope of this research. This work aims at the further development of a numerical wear calculation based on an adapted Archard model in order to be able to realistically predict the tool wear in cold forging processes. Therefore, the material characterization of the used workpiece material as well as an investigation of the worn tool dies takes place to validate a numerical wear calculation model. Furthermore, this research addresses a reduction in wear by identifying critical areas and changing the inlet geometry of the investigated demonstrator tool die. This way, conclusions can be drawn about the wear sensitivity during numerical process design, and particularly critical areas can be geometrically modified in terms of the design.
Decarbonization in Shipping Industry: A Review of Research, Technology Development, and Innovation Proposals
Authors: Mallouppas George , Yfantis Elias Ar.
Published: April 2021

This review paper examines the possible pathways and possible technologies available that will help the shipping sector achieve the International Maritime Organization’s (IMO) deep decarbonization targets by 2050. There has been increased interest from important stakeholders regarding deep decarbonization, evidenced by market surveys conducted by Shell and Deloitte. However, deep decarbonization will require financial incentives and policies at an international and regional level given the maritime sector’s ~3% contribution to green house gas (GHG) emissions. The review paper, based on research articles and grey literature, discusses technoeconomic problems and/or benefits for technologies that will help the shipping sector achieve the IMO’s targets. The review presents a discussion on the recent literature regarding alternative fuels (nuclear, hydrogen, ammonia, methanol), renewable energy sources (biofuels, wind, solar), the maturity of technologies (fuel cells, internal combustion engines) as well as technical and operational strategies to reduce fuel consumption for new and existing ships (slow steaming, cleaning and coating, waste heat recovery, hull and propeller design). The IMO’s 2050 targets will be achieved via radical technology shift together with the aid of social pressure, financial incentives, regulatory and legislative reforms at the local, regional and international level.
Small–Scale Experimental Investigation of Fatigue Performance Improvement of Ship Hatch Corner with Shot Peening Treatments by Considering Residual Stress Relaxation
Authors: Gan Jin , Gao Zi’ang , Wang Yiwen , Wang Zhou , Wu Weiguo
Published: April 2021

Ship hatch corner is a common structure in a ship and its fatigue problem has always been one of the focuses in ship engineering due to the long–term high–stress concentration state during the ship’s life. For investigating the fatigue life improvement of the ship hatch corner under different shot peening (SP) treatments, a series of fatigue tests, residual stress and surface topography measurements were conducted for SP specimens. Furthermore, the distributions of the surface residual stress are measured with varying numbers of cyclic loads, investigating the residual stress relaxation during cyclic loading. The results show that no matter which SP process parameters are used, the fatigue lives of the shot–peened ship hatch corner specimens are longer than those at unpeened specimens. The relaxation rate of the residual stress mainly depends on the maximum compressive residual stress (σRSmax) and the depth of the maximum compressive residual stress (δmax). The larger the values of σRSmax and δmax, the slower the relaxation rates of the residual stress field. The results imply that the effect of residual stress field and surface roughness should be considered comprehensively to improve the fatigue life of the ship hatch corner with SP treatment. The increase in peening intensity (PI) within a certain range can increase the depth of the compressive residual stress field (CRSF), so the fatigue performance of the ship hatch corner is improved. Once the PI exceeds a certain value, the surface damage caused by the increase in surface roughness will not be offset by the CRSF and the fatigue life cannot be improved optimally. This research provides an approach of fatigue performance enhancement for ship hatch corners in engineering application.
Blockchain-Based Address Alias System
Authors: Bodziony Norbert , Jemioło Paweł , Kluza Krzysztof , Ogiela Marek R.
Published: April 2021

In recent years, blockchains systems have seen massive adoption in retail and enterprise environments. Cryptocurrencies become more widely adopted, and many online businesses have decided to add the most popular ones, like Bitcoin or Ethereum, next to Visa or Mastercard payments. Due to the decentralized nature of blockchain-based systems, there is no possible way to revert confirmed transactions. It may result in losses caused by human error or poor design of the user interface. We created a cryptocurrency wallet with a full on-chain solution for aliasing accounts and tokens to improve user experience and avoid unnecessary errors. The aliasing system consists of a number of smart contracts deployed on top of the blockchain network that give the ability to register aliases to accounts and tokens and use them instead of opaque addresses. Our solution shows how performant modern blockchains are and presents a way of building fully decentralized applications that can compete with centralized ones in terms of performance.
Verb Errors in 5th-Grade English Learners’ Written Responses: Relation to Writing Quality
Authors: Fumero Keisey , Wood Carla
Published: April 2021

The ability to express oneself through written language is a critically important skill for long-term educational, emotional, and social success. However, despite the importance of writing, English Learner students continue to perform at or below basic levels which warrants additional efforts to identify specific areas of weakness that impact writing quality. To that end, this study aims to describe the effect of verb accuracy on writing quality ratings of 5th-grade written expository samples. This study examines the responses of 243 students in the 5th grade who differed in English proficiency. The sample included 112 English Learners and 131 English-proficient students. Verb error patterns in written samples by English Learner students are described and compared to the patterns of their monolingual English-proficient peers. Group differences were examined in verb accuracy, types of verb errors, and overall grammaticality. A regression analysis was used to examine verb accuracy as a predictor of writing quality. Findings showed that English Learner students demonstrated more verb errors than their English-speaking peers and the total number of verb errors was a significant predictor of writing quality ratings.
Shall We All Unmute? A Conversation Analysis of Participation in Online Reflection Sessions for General Practitioners in Training
Authors: van Braak Marije , Huiskes Mike , Schaepkens Sven , Veen Mario
Published: April 2021

The COVID-19 pandemic has induced many changes to education in many contexts. In this study, we describe how general practitioners in training (residents) accomplish participation in collaborative reflection sessions conducted on Zoom. In this online setting, taking part in interactions is understood to be crucial to the creation of educational value. To study forms of participation used on Zoom, we recorded three group reflection sessions and examined them with Conversation Analysis. We focused on how participation is shaped by and is contingent upon the affordances of the online environment. Our analyses show that participants explicitly orient to the interactional accomplishment of participation in frameworks that change in the various phases of case discussion. Participants establish new procedures to deal with both familiar and sometimes new problems of participation introduced by the online environment. We describe these procedures in detail to contribute to the understanding of the accomplishment of participation through situated practices such as embodied talk-in-interaction. The findings can serve training purposes in online education across both medical and non-medical curricula.
Improving the Water Quality Monitoring System in the Yangtze River Basin—Legal Suggestions to the Implementation of the Yangtze River Protection Law
Authors: Qiu Qiu , Dai Liping , Van Rijswick Helena F. M. W. , Tu Gang
Published: April 2021

The Yangtze River Basin is the largest river basin in China and has the most complex trans-boundary problems. The water quality monitoring system of the provincial boundary sections in the basin is the typical go-to system to show the interaction between administrative regions and basins. In this article, we discuss the water quality monitoring system in the basin from a legal perspective, explore the achievements and deficiencies of the system, and identify the main elements that constrain the effective operation of the system in the basin, including the fragmented competencies of monitoring institutions, the different monitoring techniques, the overlapping monitoring contents and scopes, the different data releasing channels, and the different applications of the data. We provide legislative suggestions to implement the newly enacted Yangtze River Protection Law and valuable lessons for the design of monitoring systems in other countries or (trans-boundary) basins that face a similar situation.
Laboratory Characterization of Porous Asphalt Mixtures with Aramid Fibers
Authors: Gupta Anik , Lastra-Gonzalez Pedro , Castro-Fresno Daniel , Rodriguez-Hernandez Jorge
Published: April 2021

Recent studies have shown that fibers improve the performance of porous asphalt mixtures. In this study, the influence of four different fibers, (a) regular aramid fiber (RegAR), (b) aramid fiber with latex coating (ARLat), (c) aramid fiber with polyurethane coating (ARPoly), (d) aramid fiber of length 12 mm (AR12) was evaluated on abrasion resistance and toughness of the mixtures. The functional performance was estimated using permeability tests and the mechanical performance was evaluated using the Cantabro test and indirect tensile strength tests. The parameters such as fracture energy, post cracking energy, and toughness were obtained through stress-strain plots. Based on the analysis of results, it was concluded that the addition of ARLat fibers enhanced the abrasion resistance of the mixtures. In terms of ITS, ARPoly and RegAR have positively influenced mixtures under dry conditions. However, the mixtures with all aramid fibers were found to have adverse effects on the ITS under wet conditions and energy parameters of porous asphalt mixtures with the traditional percentages of bitumen in the mixture used in Spain (i.e., approximately 4.5%).
Facilitated Synthesis of Mg2Ni Based Composites with Attractive Hydrogen Sorption Properties
Authors: Grigorova Eli , Tzvetkov Petar , Todorova Stanislava , Markov Pavel , Spassov Tony
Published: April 2021

Composites based on Mg2Ni with 5% activated carbon from apricot stones (ACAP) have been prepared by ball milling and subsequent annealing in hydrogen atmosphere. The purpose of the primary metal (Mg, Ni, and V) milling was to reduce the particle size and achieve a good contact between them, without forming intermetallic compounds. During hydriding/dehydriding at 300 °C the amount of the Mg2Ni phase progressively increased, and after 10 cycles about 50% Mg2(Ni,V) was achieved. The hydrogenation produced mainly Mg2NiH4, but small amounts of MgH2 and VHx were also detected in the powder mixture. Relatively high hydrogen storage capacity and fast hydriding/dehydriding kinetics of the Mg2.1Ni0.7V0.3—5 wt.% ACAP composite were determined both from hydrogen gas phase and electrochemically.
Effect of Stirring Pin Rotation Speed on Microstructure and Mechanical Properties of 2A14-T4 Alloy T-Joints Produced by Stationary Shoulder Friction Stir Welding
Authors: Yang Haifeng , Zhao Hongyun , Xu Xinxin , Zhou Li , Zhao Huihui , Liu Huijie
Published: April 2021

In this study, 2A14-T4 Al-alloy T-joints were prepared via stationary shoulder friction stir welding (SSFSW) technology where the stirring pin’s rotation speed was set as different values. In combination with the numerical simulation results, the macro-forming, microstructure, and mechanical properties of the joints under different welding conditions were analyzed. The results show that the thermal cycle curves in the SSFSW process are featured by a steep climb and slow decreasing variation trends. As the stirring pin’s rotation speed increased, the grooves on the weld surface became more obvious. The base and rib plates exhibit W- or N-shaped hardness distribution patterns. The hardness of the weld nugget zone (WNZ) was high but was lower than that of the base material. The second weld’s annealing effect contributed to the precipitation and coarsening of the precipitated phase in the first weld nugget zone (WNZ1). The hardness of the heat affect zone (HAZ) in the vicinity of the thermo-mechanically affected zone (TMAZ) dropped to the minimum. As the stirring pin's rotation speed increased, the tensile strengths of the base and rib plates first increased and then dropped. The base and rib plates exhibited ductile and brittle/ductile fracture patterns, respectively.
Discontinuous Dissolution Reaction in a Fe-13.5 at. % Zn Alloy
Authors: Zięba Paweł , Chronowski Mateusz , Opara Jarosław , Kogtenkova Olga A. , Straumal Boris B.
Published: April 2021

The dissolution process of a lamellar structure with α and Γ phases formed during a discontinuous precipitation reaction is investigated here with a Fe-13.5 at. % Zn alloy by means of optical microscopy and scanning and transmission electron microscopy. The α phase is a solute-depleted solid solution and the Γ phase is the intermetallic compound Fe3Zn10. The examination reveals that the dissolution occurs in a discontinuous mode by a receding of the former reaction front of the discontinuous precipitation towards the position of the original grain boundary. A new solid solution in the post-dissolution area is especially inhomogeneous and reflects the former locations of the Γ lamellae (“ghost images”) and the receding reaction front (“ghost lines”). A simulation procedure is applied to determine the Zn concentration profiles left in the post-dissolution region. Their shapes are mostly affected by the Zn content at the positions where the Γ lamellae have just been dissolved, which was also confirmed by the quantitative microchemical analysis.