bluuebunny/crossref_metadata_2025 huggingface dataset:
From entrepreneurship to established business: duration, challenges and coping tactics according to resource providers and successful entrepreneurs
Authors: De Sordi José Osvaldo , Paulo Wanderlei Lima de , Jorge Carlos Francisco Bitencourt , Bandiera Jeremias  , André André Rodrigues dos
Published: August 2024

Purpose

This paper aims to explore the perception of successful entrepreneurs and resource providers regarding the minimum operational time necessary to legitimize an enterprise as an established company, as well as the tactics used by the entrepreneurs to minimize the distrust of society during this initial period of the life cycle of the organization.

Design/methodology/approach

Data collection from two groups: (i) interviews with 62 entrepreneurs and founders of established companies; and (ii) a questionnaire completed by 77 sales managers of companies that provide businesses with resources (they practice business-to-business). Regarding analyses: (i) to analyze information, this study applied the content analysis technique; and (ii) for data, this study applied the one-sample t-test, mean comparison t-test, Pearson’s correlation test, chi-square test of association, Mann–Whitney U test and correspondence analysis technique.

Findings

In this study, a period of 42 months was identified for the legitimization of enterprises by society, in other words, the time necessary for enterprises to be recognized as an established company and a company of low risk by customers and resource providers. A set of managerial and behavioral actions practiced by successful entrepreneurs to face the difficulties they experience during the legitimization period was also identified.

Practical implications

In addition to establishing a period of 42 months for the legitimization of an enterprise in the eyes of society, a set of 15 strategies used by successful entrepreneurs was identified to combat the prejudice associated with the youthfulness of their companies. Of these, 12 are linked to managerial actions and 3 to the entrepreneur’s behavior. It should be highlighted that eight of these strategies are innovative and have yet to be addressed in the literature on mitigating risks associated with the liability of newness principle.

Originality/value

The authors discuss the legitimization of enterprises based on the perception of actors who play a fundamental role regarding entrepreneurial action: resource providers for companies, customers and successful entrepreneurs. This is a triangulation of sources, as well as a triangulation of collected data and qualitative and quantitative techniques, which sought to ensure the accuracy and reliability of the information that resulted from this analytical process.
Employee retention and company performance results: the mediating role of HRM outcomes in foreign subsidiaries of Central European MNCs
Authors: Stor Marzena
Published: August 2024

Purpose

The main goal of the article is to identify, analyze and evaluate the mediating role of HRM outcomes in the relationships between employee retention (ER) and company performance results, with a specific focus on discerning any shifts or differences in this mediation across non-crisis and crisis times in the foreign subsidiaries of MNCs.

Design/methodology/approach

The empirical research covered 200 MNCs headquartered in Central Europe. A Computer-Aided Telephone Interviewing (CATI) method was used for data collection. The raw data was adjusted using the Efficiency Index (EI) to accurately represent the relationships between the variables under study. The research hypotheses were examined, and the mediating effects were assessed through Partial Least Squares Structural Equation Modeling (PLS-SEM).

Findings

The research findings provide valuable insights by exploring the mediating role of HRM outcomes between ER and company performance results, highlighting HRM’s crucial role in enhancing results in finance, innovation and quality, particularly during crises. They underscore the strategic importance of HRM in fostering organizational resilience and innovation.

Originality/value

The study offers a new methodological contribution through introducing the EI for a precise quantitative evaluation of the relationships between ER, HRM and company performance results. However, the greatest added value of this article is the creation of the ER-HRM Mediation Theory of Organizational Resilience through Innovativeness in Crisis.
Recognize and thrive: predicting employees’ satisfaction towards fairness in reward and recognition system using explainable machine learning and text mining
Authors: Trivedi Shrawan Kumar , Srivastava Jaya , Patra Pradipta , Singh Shefali , Jena Debashish
Published: August 2024

Purpose

In current era, retaining the best-performing employees has become essential for businesses to compete in the dynamic technological landscape. Consequently, organizations must ensure that their star performers believe that company’s reward and recognition (R&R) system is fair and equal. This study aims to use an explainable machine learning (eXML) model to develop a prediction algorithm for employee satisfaction with the fairness of R&R systems.

Design/methodology/approach

The current study uses state-of-the-art machine learning models such as Naive Bayes, Decision Tree C5.0, Random Forest and support vector machine-RBF to predict employee satisfaction towards fairness in R&R. The primary data used in the study has been collected from the employees of a large public sector undertaking from an emerging economy. This study also proposes a novel improved Naïve Bayes (INB) algorithm, the efficiency of which is compared with the state-of-the-art algorithms.

Findings

It is seen that the proposed INB model outperforms the state-of-the-art algorithms in many scenarios. Further, the proposed model and feature interaction are explained using the explainable machine learning (XML) concept. In addition, this study incorporates text mining techniques to corroborate the results from XML and suggests that “Transparency”, “Recognition”, “Unbiasedness”, “Appreciation” and “Timeliness in reward” are the most important features that impact employee satisfaction.

Originality/value

To the best of the authors’ knowledge, this is one of the first studies to use INB algorithm and mixed method research (text mining along with machine learning algorithms) for the prediction of employee satisfaction with respect to the R&R system.
Exploring the determinants of housing price bubbles in the Turkish economy: a COVID-related framework
Authors: Doruk Ömer Tuğsal
Published: August 2024

Purpose

This study aims to explore a novel framework for housing price bubbles in the Turkish economy during the pandemic. It examines the probability of housing bubble formation relative to the pre-pandemic period and identifies possible determinants of housing bubbles in the Turkish economy.

Design/methodology/approach

In this study, a two-stage novel estimation method is applied. In the first stage, bubble periods are identified through the right-tailed supremum augmented Dickey–Fuller test. In the second stage, the determinants of these bubbles are identified, and the housing bubble determinants during the COVID-19 pandemic are compared to the pre-pandemic period.

Findings

The findings indicate that there is an asset price bubble in the housing market during the pandemic period. Furthermore, mortgage credit expansion, mortgage credit rates and the depreciation of the Turkish Lira against the USD could increase housing bubble formation. However, housing sector sales to foreign investors do not contribute to housing bubble formation during the pandemic in the Turkish housing market.

Originality/value

To the best of the author’s knowledge, this is the first study to address the relative determinants of housing bubbles in an emerging market context during the pandemic.
Clinical decision support in Tanzanian healthcare facilities: an activity theory approach to analysing tools and procedures for enhanced patient care
Authors: Mwogosi Augustino , Mambile Cesilia
Published: August 2024

Purpose

The study aims to explore the utilisation of Clinical Decision Support (CDS) tools in Tanzanian healthcare facilities by identifying the tools used, the challenges encountered and the adaptive strategies employed by healthcare practitioners. It utilises an Activity Theory (AT) approach to understand the dynamic interactions between healthcare providers, CDS tools and the broader healthcare system.

Design/methodology/approach

The research adopts a qualitative approach in two prominent regions of Tanzania, Dar es Salaam and Dodoma. It involves semi-structured interviews with 26 healthcare professionals and key stakeholders across ten healthcare facilities, supplemented by document reviews. The study employs AT to analyse the interactions between healthcare professionals, CDS tools and the broader healthcare system, identifying best practices and providing recommendations for optimising the use of CDS tools.

Findings

The study reveals that Tanzanian healthcare practitioners predominantly rely on non-computerised CDS tools, such as clinical guidelines prepared by the Ministry of Health. Despite the availability of Health Information Systems (HIS), these systems often lack comprehensive decision-support functionalities, leading practitioners to depend on traditional methods and their professional judgement. Significant challenges include limited accessibility to updated clinical guidelines, unreliable infrastructure and inadequate training. Adaptive strategies identified include using non-standardised tools like Medscape, professional judgement and reliance on past experiences and colleagues’ opinions.

Research limitations/implications

The investigation was constrained by access limitations because it was challenging to get some respondents to share information. However, a sufficient number of individuals participated in the interviews, and their knowledge was very beneficial in understanding the procedures and tools for clinical decision support.

Originality/value

This study contributes to AT by extending its application to a low-resource healthcare setting, uncovering new dimensions of the theory related to socio-cultural and technological constraints in healthcare facilities in Tanzania. It provides valuable insights into the practical barriers and facilitators of HIS and CDS tool implementation in developing countries, emphasising the need for context-specific adaptations, robust training programs and user-centred designs. The findings highlight the resilience and imagination of healthcare practitioners in adapting to systemic limitations, offering recommendations to enhance clinical decision-making and improve patient care outcomes in Tanzania.
Designing sport and physical activity interventions for children and adolescents with ADHD: a conceptual framework
Authors: Meggs Jennifer
Published: August 2024

Purpose

This paper aims to present a theoretical framework and underpinning evidence to support researchers and practitioners to systematically design sport and exercise interventions.

Design/methodology/approach

The framework highlights the theoretical underpinnings and practical feasibility considerations that are important when designing sport and exercise interventions for children and adolescents with attention deficit hyperactivity disorder (ADHD).

Findings

Future research may wish to apply and evaluate the utility of this framework and research and practice and make recommendations for further refinement.

Originality/value

The quality and strength of conclusions from this body of research has been undermined by a lack of methodological quality and clarity in these studies. One criticism has been the lack of an evidence based, transparent and consistent approach to the design of physical activity and sport interventions and selection of outcome measures. This paper will facilitate the transparent and evidence-based decision-making to guide the design of sport/physical activity interventions for children/adolescents with ADHD.
Tourism routes development: critical success factors
Authors: Pedrosa André , Martins Filomena , Breda Zélia , Lois González Rubén , Costa António Pedro
Published: August 2024

Purpose

This study aims to identify Critical Success Factors (CSFs) for tourism route development and proposes a tailored conceptual model. It addresses a comprehensive range of tourism routes, considering their respective goals and performance.

Design/methodology/approach

The authors applied a qualitative approach to investigate five tourism routes, interviewing 31 current and former members and examining secondary data from organisational documents. A conceptual model was developed through content analysis of transcripts and secondary data.

Findings

Based on the identified CSFs, the model is organised into six components: Product, Goals, Resources, Governance, Activities and Performance assessment.

Research limitations/implications

The study analyses various tourism routes concerning their products, implementation levels, goals, performance and perceived success.

Practical implications

Most respondents are public authorities from European countries. Besides, consideration should be given to developing quantitative research to validate the derived theory.

Social implications

The model may facilitate participants in enhancing and developing tourism routes, thereby contributing to achieving sustainable development goals related to rural-urban connections and tourism partnerships.

Originality/value

The development of tourism routes is expected to impact socio-economic development in rural/peripheral areas positively.
Factors related to health literacy of recurrent stroke prevention among older adult stroke survivors
Authors: Toonsiri Chanandchidadussadee , Jullamate Pornchai , Sianghwong Harit , Acedera Louela Cordova
Published: August 2024

Purpose

This correlational study conducted at Ban Phaeo Hospital, Thailand, aimed to assess the health literacy levels of 105 older adult stroke survivors from November 2021 to February 2022.

Design/methodology/approach

The study uncovered a moderate level of health literacy among participants, as indicated by a mean score of 66.85 (SD = 8.151).

Findings

Significant positive correlations were observed between health literacy and several key factors, including patient-provider relationships (r = 0.550, p < 0.001), social support (r = 0.548, p < 0.001) and perceived health status (r = 0.484, p < 0.001). These findings emphasize the interconnectedness of health literacy with critical elements of healthcare engagement and well-being.

Research limitations/implications

To advance stroke prevention in the older adult population, future research should focus on evaluating nurse-led interventions designed to enhance health literacy.

Social implications

Raising awareness about the influence of patient-provider relationships, social support networks and perceived health status represents the initial stride toward a successful strategy for elevating health literacy and preventing recurrent strokes in this demographic.

Originality/value

This work is entirely original, all authors listed contributed to the project and have approved the final draft for submission. This work of art has not been published or is under consideration elsewhere. This study addresses the crucial gap in the literature by uncovering moderate health literacy levels among older adult stroke survivors. It delves into the intricacies of health literacy in this population, establishing correlations with patient-provider relationships, social support and perceived health status. The study emphasizes the critical role of health literacy in healthcare engagement and well-being, advocating for nurse-led interventions to enhance health literacy and prevent recurrent strokes in older adults.
Environmental sustainability in the digital age: unraveling the effect of social media on green purchase intention
Authors: Nazish Mohammed , Khan Mohammed Naved , Khan Zebran
Published: August 2024

Purpose

The unethical use of natural resources is contributing to the increasing environmental degradation. The depleting environment poses a threat to the sustainability of present and future generations. This paper aims to investigate the impact of social media on the green purchase intention of consumers. The research adopts the theory of reciprocal determinism to integrate the variables of social media, green product knowledge, green consumption values and drive for environmental responsibility, assessing their collective impact on green purchase intention.

Design/methodology/approach

Data were gathered from a sample of 310 young consumers using a structured close-ended questionnaire. The proposed hypothesis was tested by employing PLS-SEM.

Findings

The study validates that social media (SM) has the ability to shape consumers' intention to choose more eco-friendly products. In addition to social media, green consumption values and the drive for environmental responsibility exert a significant influence on green purchase intention. However, green product knowledge did not have a significant impact on green purchase intention nor did mediate the relationship between social media and green purchase intention.

Originality/value

The existing scholarly literature indicates that researchers have employed a variety of theories as the basis for their studies aimed at predicting intentions and behaviors related to environmentally conscious purchases. To our knowledge, this is the first study to incorporate social media in the theory of reciprocal determinism. Notably, the paper represents the inaugural investigation in the context of an emerging economy to incorporate green product knowledge as a mediating variable.
Decoupled responses of the stability of above‐ and belowground productivity to drought and clipping in an alpine meadow
Authors: Ma Fangfang , Zhang Ruiyang , Svenning Jens‐Christian , Zhang Fangyue , He Yunlong , Wang Jinsong , Tian Dashuan , Zhou Qingping , Niu Shuli
Published: August 2024

Extreme drought and intensification of land use pose substantial threats to ecosystem stability. However, existing studies that assess ecosystem stability focus primarily on the stability of aboveground net primary productivity (ANPP), while the stability of belowground net primary productivity (BNPP) is often not considered.

Here, we examined the response patterns and drivers of ANPP stability and BNPP stability in an alpine meadow to drought and clipping (simulating grazing and mowing) by the implementation of five levels of simulated precipitation (1/12, 1/4, 1/2, 3/4 and ambient precipitation) and clipping (unclipped vs. clipped) treatments over 7 years (2016–2022).

The results showed that extreme drought decreased ANPP stability, while moderate drought increased BNPP stability and net primary productivity stability. The findings highlight the importance of jointly considering above‐ and belowground processes when evaluating ecosystem stability. Moreover, clipping did not have an impact on ANPP stability but reduced BNPP stability, and clipping differentially affected the stability of ANPP and BNPP in response to extreme drought. Furthermore, ANPP stability was largely determined by species temporal asynchrony rather than richness, whereas dominant species stability strongly contributed to the variation in BNPP stability of this alpine meadow faced with drought and clipping.

Synthesis: In general, these results provide experimental evidence for the decoupling of the responses of above‐ and belowground productivity stability to extreme drought and clipping. Our findings indicate that aboveground responses should not be used as the sole indicator of the whole ecosystem consequences of extreme drought and disturbance factors such as grazing or mowing, emphasizing the need to evaluate ecosystem stability from a whole ecosystem perspective.
Origin and Evolution Process of Overpressure in the Shahezi Formation of Xujiaweizi Fault Depression in the Northern Songliao Basin, NE China
Authors: ZHANG Chengju , JIANG Zhenxue , LU Jiamin , SHI Lidong , BI Zhongyu , SUN Lidong , YANG Liang , LI Xiaomei , LIU Jiajun , MIAO Huan
Published: August 2024

It is of great significance for deep oil and gas exploration to understand the origin and evolution behind overpressure. Overpressure occurs in the deep Shahezi Formation of Xujiaweizi fault depression. However, due to limited degree of exploration, there are some problems in the study area, such as unclear understanding of the origin of overpressure and the vague investigation of overpressure evolution. To clarify the impact of overpressure on oil and gas migration and accumulation in the study area, this study focuses on the research of the origin and evolution of overpressure in the Shahezi Formation of the study area, utilizing single well logging parameters and combining methods such as microthermometry of fluid inclusions, laser Raman spectrum, and basin simulation. The results show that the overpressure of the Shahezi Formation in Xujiaweizi fault depression is primarily generated by hydrocarbon generation pressurization, and the evolution of overpressure is closely related to hydrocarbon generation. The development of overpressure can be divided into two evolutionary stages: early hydrocarbon generation pressurization and late uplift release, with slight variations in different regions. Tight glutenite gas reservoirs in the Shahezi Formation are characterized by continuous charging. The overall charging period ranges from the late Denglouku to the early Mingshui (110–67 Ma ago). There is an obvious paleo‐overpressure during the gas reservoir formation period. The gas generation period of source rocks occurred approximately 125–60 Ma ago, and the main gas generation period (112–67 Ma ago) highly coincides with the period of natural gas charging. The anomalously high pressure during the accumulation period is considered the significant driving force for natural gas charging. In addition, the sustained effect of overpressure provides better conditions for the preservation of tight gas reservoirs within the source. The results of the study are of guiding significance for the in‐depth exploration and development of deep tight sandstone gas in the Shahezi Formation of Xujiaweizi fault depression.
Norway: Political Developments and Data in 2023
Authors: BERGH JOHANNES , KARLSEN RUNE
Published: August 2024

An unusually large number of political scandals left their mark on Norwegian politics in 2023. Most of the scandals involved conflicts of interest for current and former government ministers, and they led to several Cabinet resignations and dismissals. The local elections in September were a big win for the two main parties on the right of Norwegian politics. The two centre‐left parties that constitute the national governing coalition fared poorly in the elections.
Systematic review of barriers, facilitators, and tools to promote shared decision making in the emergency department
Authors: Ubbink Dirk T. , Matthijssen Melissa , Lemrini Samia , van Etten‐Jamaludin Faridi S. , Bloemers Frank W.
Published: August 2024

Objective

The objective was to systematically review all studies focusing on barriers, facilitators, and tools currently available for shared decision making (SDM) in emergency departments (EDs).

Background

Implementing SDM in EDs seems particularly challenging, considering the fast‐paced environment and sometimes life‐threatening situations. Over 10 years ago, a previous review revealed only a few patient decision aids (PtDAs) available for EDs.

Methods

Literature searches were conducted in MEDLINE, Embase, and Cochrane library, up to November 2023. Observational and interventional studies were included to address barriers or facilitators for SDM or to investigate effects of PtDAs on the level of SDM for patients visiting an ED.

Results

We screened 1946 studies for eligibility, of which 33 were included. PtDAs studied in EDs address chest pain, syncope, analgesics usage, lumbar puncture, ureterolithiasis, vascular access, concussion/brain bleeding, head‐CT choice, coaching for elderly people, and activation of patients with appendicitis. Only the primary outcome was meta‐analyzed, showing that PtDAs significantly increased the level of SDM (18.8 on the 100‐point OPTION scale; 95% CI 12.5–25.0). PtDAs also tended to increase patient knowledge, decrease decisional conflict and decrease health care services usage, with no obvious effect on overall patient satisfaction. Barriers and facilitators were identified on three levels: (1) patient level—emotions, health literacy, and their own proactivity; (2) clinician level—fear of medicolegal consequences, lack of SDM skills or knowledge, and their ideas about treatment superiority; and (3) system level—time constraints, institutional guidelines, and availability of PtDAs.

Conclusions

Circumstances in EDs are generally less favorable for SDM. However, PtDAs for conditions seen in EDs are helpful in overcoming barriers to SDM and are welcomed by patients. Even in EDs, SDM is feasible and supported by an increasing number of tools for patients and physicians.
BNST GluN2D‐containing NMDARs contribute to ethanol intake but not negative affective behaviors in female mice
Authors: Doyle Marie A. , Salimando Gregory J. , Altemus Megan E. , Badt Justin K. , Bedenbaugh Michelle N. , Vardy Alexander S. , Adank Danielle N. , Park Anika S. , Winder Danny G.
Published: August 2024

Background

Alcohol use disorder (AUD) is a chronic, relapsing disease, highly comorbid with anxiety and depression. The bed nucleus of the stria terminalis (BNST) and Crh+ neurons in this region play a key role in chronic ethanol‐induced increases in volitional intake, hypothesized to be driven by emergent negative affective behaviors. Excitatory N‐methyl‐d‐aspartate receptors (NMDARs) are a major target of ethanol, and chronic ethanol exposure has been shown to regulate NMDAR function and expression. Specifically, GluN2D subunit‐containing NMDARs have emerged as a target of interest due to their limited distribution and potential roles in affective behavior.

Methods

Male and female mice underwent a home cage chronic drinking forced abstinence model (CDFA) to assess the impact of 1 day or 2 weeks of ethanol abstinence on BNST synaptic transmission and BNST Grin gene expression. Constitutive and conditional BNST GluN2D knockout mice were used to assess the impact of GluN2D deletion on continuous access ethanol intake as well as negative affect behaviors, using the open field, elevated zero maze, and forced swim tasks.

Results

We report here that excitatory transmission undergoes time‐dependent upregulation in BNST Crh+ cells. Further, knockdown of dorsal BNST (dBNST) GluN2D expression significantly decreases ethanol intake in female, but not male, mice. While BNST Grin2b expression was significantly increased in protracted abstinence following CDFA, no differences in Grin2d expression were observed in the dBNST or dBNST Crh+ neurons. Finally, we find that deletion of GluN2D fails to alter negative affect in ethanol‐naïve female mice.

Conclusions

These data suggest a role for BNST GluN2D‐containing NMDARs in ethanol drinking but not ethanol abstinence, highlighting sex differences and behavioral specificity. Overall, these data further suggest roles for BNST synaptic signaling in volitional ethanol intake that are partially independent of actions on affective behavior.
Rising to the challenge: The motivation to champion routine intimate partner violence screening in rural emergency departments
Authors: Saberi Elham , Hutchinson Marie , Hurley John
Published: August 2024

Objective

To understand the motivations of champions who worked to bring about system and practice change that supported routine screening for intimate partner violence (IPV) in two rural emergency departments (EDs).

Introduction

Practice changes are required to achieve routine and effective identification and response to IPV. Nurses play a significant role in affecting such practice change. This paper identifies the motivations of champions in the ED setting who successfully brought about such change.

Setting

The EDs of two Level 5 tertiary hospitals within a rural Local Health District (LHD) of New South Wales, Australia.

Participants

Twenty‐three individuals who identified as champions and worked to introduce routine IPV screening in two rural hospital EDs.

Design

Qualitative longitudinal semi‐structured interviews employing a process of constant comparison and an interpretive framework to analyse data thematically. Interviews were carried out between June and August 2017 and again between July and August 2019.

Results

Over the period of the study, routine screening was established, and screening rates steadily increased from a low baseline to a significantly higher rate. Three aspects of champion motivation emerged from the analysis: formation of an identity as a champion, making a difference to a significant social justice issue and providing quality and community‐relevant care.

Conclusions

This study is the first study to report on champions and their motivation as they supported IPV practice change in the ED. The findings highlight the capacity for innovation in rural health services, with important implications for other settings looking to translate similar programs. Understanding motivating factors may assist in improved utilisation and support for champions. This is vital if champions are to bring about required practice change within their service and ensure the needs of individuals experiencing IPV are effectively met.
Aspirin hypersensitivity diagnostic index (AHDI): In vitro test for diagnosing of N‐ERD based on urinary 15‐oxo‐ETE and LTE4 excretion
Authors: Mastalerz Lucyna , Trąd Gabriela , Szatkowski Piotr , Ćmiel Adam , Gielicz Anna , Kacorzyk Radosław , Plutecka Hanna , Szaleniec Joanna , Gawlewicz‐Mroczka Agnieszka , Jakieła Bogdan , Sanak Marek
Published: August 2024

Background

15‐oxo‐eicosatetraenoic acid (15‐oxo‐ETE), is a product of arachidonic acid (AA) metabolism in the 15‐lipoxygenase‐1 (15‐LOX‐1) pathway. 15‐oxo‐ETE was overproduced in the nasal polyps of patients with nonsteroidal anti‐inflammatory drug–exacerbated respiratory disease (N‐ERD). In this study we investigated the systemic biosynthesis of 15‐oxo‐ETE and leukotriene E4 (LTE4) and assessed their diagnostic value to identify patients with N‐ERD.

Methods

The study included 64 patients with N‐ERD, 59 asthmatics who tolerated aspirin well (ATA), and 51 healthy controls. A thorough clinical characteristics of asthmatics included computed tomography of paranasal sinuses. Plasma and urinary 15‐oxo‐ETE levels, and urinary LTE4 excretion were measured using high‐performance liquid chromatography and tandem mass spectrometry. Repeatability and precision of the measurements were tested.

Results

Plasma 15‐oxo‐ETE levels were the highest in N‐ERD (p < .001). A receiver operator characteristic (ROC) revealed that 15‐oxo‐ETE had certain sensitivity (64.06% in plasma, or 88.24% in urine) for N‐ERD discrimination, while the specificity was rather limited. Modeling of variables allowed to construct the Aspirin Hypersensitivity Diagnostic Index (AHDI) based on urinary LTE4‐to‐15‐oxo‐ETE excretion corrected for sex and the Lund‐Mackay score of chronic rhinosinusitis. AHDI outperformed single measurements in discrimination of N‐ERD among asthmatics with an area under ROC curve of 0.889, sensitivity of 81.97%, specificity of 87.23%, and accuracy of 86.87%.

Conclusions

We confirmed 15‐oxo‐ETE as a second to cysteinyl leukotrienes biomarker of N‐ERD. An index based on these eicosanoids corrected for sex and Lund‐Mackay score has a similar diagnostic value as gold standard oral aspirin challenge in the studied group of patients with asthma.
Innovative all‐in‐one exome sequencing strategy for diagnostic genetic testing in male infertility: Validation and 10‐month experience
Authors: Oud Manon S. , de Leeuw Nicole , Smeets Dominique F. C. M. , Ramos Liliana , van der Heijden Godfried W. , Timmermans Raoul G. J. , van de Vorst Maartje , Hofste Tom , Kempers Marlies J. E. , Stokman Marijn F. , D'Hauwers Kathleen W. M. , Faas Brigitte H. W. , Westra Dineke
Published: August 2024

Background

Current guidelines indicate that patients with extreme oligozoospermia or azoospermia should be tested for chromosomal imbalances, azoospermia factor (AZF) deletions and/or CFTR variants. For other sperm abnormalities, no genetic diagnostics are recommended.

Objectives

To determine whether exome sequencing (ES) with combined copy number variant (CNV) and single nucleotide variant (SNV) analysis is a reliable first‐tier method to replace current methods (validation study), and to evaluate the diagnostic yield after 10 months of implementation (evaluation study).

Materials and Methods

In the validation study, ES was performed on DNA of patients already diagnosed with AZF deletions (n = 17), (non‐)mosaic sex chromosomal aneuploidies or structural chromosomal anomalies (n = 37), CFTR variants (n = 26), or variants in known infertility genes (n = 4), and 90 controls. The data were analyzed using our standard diagnostic pipeline, with a bioinformatic filter for 130 male infertility genes. In the evaluation study, results of 292 clinical exomes were included.

Results

All previously reported variants in the validation cohort, including clinically relevant Y‐chromosomal microdeletions, were correctly identified and reliably detected. In the evaluation study, we identified one or more clinically relevant genetic anomalies in 67 of 292 of all cases (22.9%): these included aberrations that could have been detected with current methods in 30 of 67 patients (10.2% of total), (possible) (mono)genetic causes in the male infertility gene panel in 28 of 67 patients (9.6%), and carriership of cystic fibrosis in nine of 67 patients (3.1%).

Conclusion

ES is a reliable first‐tier method to detect the most common genetic causes of male infertility and, as additional genetic causes can be detected, in our evaluation cohort the diagnostic yield almost doubled (10.2%–19.8%, excluding CF carriers). A genetic diagnosis provides answers on the cause of infertility and helps the professionals in the counseling for treatment, possible co‐morbidities and risk for offspring and/or family members. Karyotyping will still remain necessary for detecting balanced translocations or low‐grade chromosomal mosaicism.
Are listed SMEs ready for the corporate sustainability reporting directive? Evidence from Italy
Authors: Pizzi Simone , Coronella Lorenzo
Published: August 2024

This paper explores the sustainability reporting practices of listed small‐ and medium‐sized enterprises (SMEs) in the context of the Corporate Sustainability Reporting Directive (CSRD). Utilizing institutional theory as a framework, this study employs dynamic panel data and logistic regressions to investigate how these SMEs respond to isomorphic pressures. The findings reveal a significant presence of mimetic isomorphism, where these companies tend to imitate the sustainability reporting behaviours of all listed companies, not just those of their direct SME competitors. Interestingly, the study also finds that geographical factors do not significantly influence the sustainability reporting practices of these SMEs. This research makes a notable contribution to the ongoing discussion about mandatory sustainability reporting in Europe, being one of the first in‐depth analyses of how European‐listed SMEs are adapting to new sustainability reporting regulations.
A novel index combining fecal immunochemical test, DNA test, and age improves detection of advanced colorectal adenoma
Authors: Inoue Yukari , Ishiguro Akiyo , Suehiro Yutaka , Kunimune Yuki , Yamaoka Yuko , Hashimoto Shinichi , Nakamura Katsuhiko , Goto Atsushi , Hamabe Koichi , Matsumoto Toshihiko , Tomochika Shinobu , Higaki Shingo , Fujii Ikuei , Suzuki Chieko , Koga Michiko , Tsutsumi Takeya , Lim Lay Ahyoung , Matsubara Yasuo , Yotsuyanagi Hiroshi , Nagano Hiroaki , Yamamoto Naoki , Sakaida Isao , Takami Taro , Nishioka Mitsuaki , Yamasaki Takahiro
Published: August 2024

Although the fecal immunochemical test for hemoglobin (FIT) is a widely used screening test for colorectal cancer, it is not sensitive enough to detect advanced colorectal adenoma. To address this issue, we performed this study to investigate whether combining the FIT and fecal DNA testing of methylated somatostatin (SST) could improve diagnostic performance for advanced colorectal adenoma. We collected feces from 79 healthy subjects with negative results on colonoscopy, 43 patients with non‐advanced colorectal adenoma, 117 patients with advanced colorectal adenoma, and 126 patients with colorectal cancer. After fecal DNA was incubated with methylation‐sensitive restriction enzymes, SST methylation levels were measured by droplet digital PCR. Using logistic multivariate analysis, we established a prediction formula for detecting colorectal neoplasia and named it the FAMS (FIT, age, methylated SST) index. The diagnostic performance of a single use of FIT for advanced colorectal adenoma showed a sensitivity of 29.1% (34/117) and specificity of 89.3% (109/122). In contrast, the FAMS index showed a sensitivity of 56.4% (66/117) at a similar specificity point of 91.0% (111/122). Furthermore, even at the higher specificity point of 94.3% (115/122), the sensitivity was still higher than that of FIT, reaching 42.7% (50/117). As the FAMS index showed better diagnostic performance for advanced colorectal adenoma than a single use of FIT, the FAMS index could be a promising tool for detecting advanced colorectal adenoma.
Complication, vertical bone gain, volumetric changes after vertical ridge augmentation using customized reinforced PTFE mesh or Ti‐mesh. A non‐inferiority randomized clinical trial
Authors: Cucchi Alessandro , Bettini Sofia , Tedeschi Lucia , Urban Istvan , Franceschi Debora , Fiorino Antonino , Corinaldesi Giuseppe
Published: August 2024

Objective

The aim of this non‐inferiority randomized clinical trial was to compare the surgical and healing complications, vertical bone gain, and volumetric bone changes after vertical ridge augmentation using two different approaches: customized Ti‐reinforced d‐PTFE mesh versus customized CAD/CAM Ti‐mesh.

Materials and Methods

Fifty patients with vertical bone defects were randomly treated with Ti‐reinforced d‐PTFE mesh (control group) or CAD/CAM Ti‐mesh (test group) and a mix of autogenous bone and deproteinized bovine bone matrix. Surgical and healing complication rates (SCR‐HCR), vertical bone gain (VBG), regenerated bone volume (RBV), and regeneration rates (RR and ERR) were recorded and analysed [significance level (α) of 0.05].

Results

Of the 50 patients, 48 underwent bone augmentation surgery. SCR were 4% and 12% in PTFE and Ti‐mesh, whereas HCR were 12.5% and 8.3%. VBG were 5.79 ± 1.71 mm (range: 3.2–8.8 mm) in the PTFE group and 5.18 ± 1.61 mm (range: 3.1–8.0 mm) in the Ti‐mesh group (p = .233), whereas RBV were 1.46 ± 0.48 cc and 1.26 ± 0.55. RR was 99.5% and 87.0%, demonstrating a statistically significant difference (p = .013). Finally, the values related to pseudo‐periosteum, bone density, and implant stability were similar in the two study groups. Osseointegration rates were 98.2% and 98.3%.

Conclusions

This study confirmed the non‐inferiority of customized CAD/CAM titanium meshes with respect to reinforced PTFE meshes in terms of surgical and healing complications. Although PTFE meshes showed higher vertical bone gain and regeneration rates than Ti‐meshes, no significant differences were found.
Effects of high‐intensity chronic noise on spatial memory in male versus female rats
Authors: Zhvania Mzia G. , Japaridze Nadezhda , Tizabi Yousef , Pochkhidze Nino , Lobzhanidze Giorgi
Published: August 2024

The detrimental effects of high‐intensity noise on the auditory system and emotional status, including the induction of anxiety, are well documented. Preclinical as well as epidemiological and clinical studies have solidly established differential responses between males and females to various stressful stimuli, including high‐intensity white noise (HIWN). However, whether chronic exposure to noise affects cognitive functions and whether this effect is sex dependent has not been adequately addressed. In this study, we used two cognitive test paradigms, such as the Morris water maze (MWM) and the multi‐branch maze (MBM), to test the effect of chronic HIWN on indices of spatial learning and memory in both male and female Wistar rats. Our findings indicate that daily (1 h) exposure to 100 dB of noise for 30 consecutive days induces different task‐dependent responses in male versus female rats. For example, in the acquisition phase of MWM, female rats exposed to noise outperformed their male counterparts at twice the speed. Similarly, in the MBM test, noise‐exposed female rats outperformed the male rats in reaching the nest box. It is clear from these studies that noise impairs cognitive functions twice as negatively in male rats as in female rats. Thus, sex‐related differences in spatial learning and memory in response to HIWN must be taken into consideration when investigating the neurobiological components and/or treatment modalities.
The effect of restructuring internationalized companies on performance: Evidence from European firms
Authors: Forcadell Francisco Javier , Romero‐Jordán Desiderio , Sanchez‐Riofrio Angelica , Guerras‐Martín Luis Ángel
Published: August 2024

This paper analyzes the effect of restructuring internationalized companies on financial performance. We hypothesize that companies implementing restructuring strategies in internationalized companies obtain better financial performance than non‐internationalized companies that restructure. Both strategies exploit resource complementarities that promote improved resource access, generation, and use. We empirically analyze a sample of 932 companies from 15 European Union countries from 1998 to 2011, including periods of economic growth and financial crisis. Our study extends the internationalization literature by demonstrating that internationalization improves financial performance (return on assets) for companies facing narrowing or refocusing their scope.
Dissecting Henipavirus W proteins conformational and fibrillation properties: contribution of their N‐ and C‐terminal constituent domains
Authors: Pesce Giulia , Gondelaud Frank , Ptchelkine Denis , Bignon Christophe , Fourquet Patrick , Longhi Sonia
Published: August 2024

The Nipah and Hendra viruses are severe human pathogens. In addition to the P protein, their P gene also encodes the V and W proteins that share with P their N‐terminal intrinsically disordered domain (NTD) and possess distinct C‐terminal domains (CTDs). The W protein is a key player in the evasion of the host innate immune response. We previously showed that the W proteins are intrinsically disordered and can form amyloid‐like fibrils. However, structural information on W CTD (CTDW) and its potential contribution to the fibrillation process is lacking. In this study, we demonstrate that CTDWS are disordered and able to form dimers mediated by disulfide bridges. We also show that the NTD and the CTDW interact with each other and that this interaction triggers both a gain of secondary structure and a chain compaction within the NTD. Finally, despite the lack of intrinsic fibrillogenic properties, we show that the CTDW favors the formation of fibrils by the NTD both in cis and in trans. Altogether, the results herein presented shed light on the molecular mechanisms underlying Henipavirus pathogenesis and may thus contribute to the development of targeted therapies.
Effectiveness of mass marking of juvenile sterlet (Acipenser ruthenus) with alizarin red S stain on field detection
Authors: Šindler Martin , Buřič Miloš , Plesch Martin , Franta Pavel , Drozd Bořek
Published: August 2024

Sterlet (Acipenser ruthenus), one of the last sturgeons in the Danube basin, is regularly stocked in national and international restoration programs, but the efficacy of stocking has not yet been evaluated. Effectiveness of stocking should involve marking and evaluating growth and survival of juveniles. Chemical marking with alizarin red S (ARS) was evaluated to establish optimal ARS staining approaches for juvenile sterlet. Bathing in a 100–200 mg l−1 ARS concentration for 12 h had no affect on fish mortality or growth. Use of a green laser on the upper five external structures (dorsal, lateral, and ventral scutes and rostral and anal plates) allowed easy detection for at least a year. Simultaneous use of multiple external structures was effective for distinguishing stocked from wild fish without harm or sacrifice. We conclude that ARS staining enabled a cost‐effective, quick, and labour‐nonintensive way to mark sterlet, with a high‐field detectability and minimal previous experience required.
LOST AT SEA: MARITIME MODERNITY AND THE NEGOTIATION OF IDENTITY IN THEODOR STORM'S ‘HANS UND HEINZ KIRCH’
Authors: Hammarfelt Linda Karlsson
Published: August 2024

This article explores the depiction of the sailor and the conflict between bourgeois life and its fluid ‘other’ in Theodor Storm's novella ‘Hans und Heinz Kirch’ (1883). The analysis brings together spatial theory, in particular Deleuze and Guattari's understanding of ‘smooth’ and ‘striated’ spaces, and reception aesthetics. Next to the ‘smooth’, fluid border of the ocean, the article identifies other in‐between areas which play a central role in the novella as spheres of negotiating story and identity: the sailor's skin as the border between self and other; and the omissions of language and narration. It argues that the many ‘Leerstellen’ of the text correspond to the openness of the sea and open up to a ‘travelling’ reading. Readers are invited to actively explore the open spaces and ambiguities of the text and thus contribute to the production of meaning. Placing Storm's novella in the context of maritime modernity and regarding correspondences between the narrative discourse and the conflict between ‘smooth’ and ‘striated’ space, this article offers a new perspective on Storm.
THE INFLUENCE OF BRIGITTE REIMANN'S FRANZISKA LINKERHAND ON THE POLITICAL SONGS OF GERHARD GUNDERMANN
Authors: Robb David
Published: August 2024

Gerhard Gundermann was an East German open cast miner and ‘Liedermacher’ who died prematurely in 1998 at the age of forty‐three. Although he is known for his controversial involvement with the Stasi in his early career, very little has been written about his art, including the ‘Liedertheater’ work he performed with Brigade Feuerstein in the GDR. This article looks at the role of literary intertextuality in the productions of this group between 1978 and 1988. It specifically examines Gundermann's connection with Brigitte Reimann's socially critical novel Franziska Linkerhand, particular themes from which recur in his songs and theatrical scenes. These include ‘waiting’, as Gundermann and his contemporaries struggled to assert themselves, faced with the older generation's stranglehold on power and information. The Brigade Feuerstein productions will be examined against the background of Gundermann's own protracted conflict with the Sozialistische Einheitspartei Deutschlands (SED) in the years 1978 to 1984. Another theme of Franziska Linkerhand which appears in his work are the portraits of characters from the margins of society that conflict with ideal heroic depictions of workers as propagated by the SED. In the final decade of Gundermann's life, society's ‘losers’ continue to be portrayed in songs such as ‘Und musst du weinen’.