bluuebunny/crossref_metadata_2025 huggingface dataset:
Left Atrial Strain as a Predictor of Early Anthracycline-Induced Chemotherapy-Related Cardiac Dysfunction: A Pilot Systematic Review and Meta-Analysis
Authors: Goyal Aman , Abbasi Haleema Qayyum , Yakkali Shreyas , Khan Abdul Moiz , Tariq Muhammad Daoud , Sohail Amir Humza , Khan Rozi
Published: July 2024

Background: Chemotherapy-related cardiac dysfunction (CTRCD) significantly affects patients undergoing anthracycline (AC) therapy, with a prevalence ranging from 2% to 20%. Reduced left ventricular ejection fraction (LVEF) and left ventricular global longitudinal strain (LV GLS) are prognostic parameters for CTRCD detection. Our study aimed to investigate the role of emerging parameters such as left atrial strain (LAS). Methods: We searched multiple databases for studies comparing LAS changes post-AC versus pre-AC therapy in patients with cancer. Primary outcomes included left atrial reservoir strain (LASr), left atrial conduit strain (LAScd), and left atrial contractile strain (LASct). RevMan (v5.4) was used to pool the standardized mean difference (SMD) under a random effects model, with p < 0.05 as the threshold for statistical significance. Results: In an analysis of 297 patients across five studies, AC therapy significantly lowered LASr (SMD = −0.34, 95% CI:−0.55, −0.14, I2 = 0%, p = 0.0009) and LAScd (SMD = −0.41, 95% CI: −0.59, −0.23, I2 = 0%, p < 0.00001) levels. Conversely, LASct demonstrated no significant change (SMD = 0.01, 95% CI: −0.21, 0.23, I2 = 9%, p = 0.95). AC therapy also significantly reduced LV GLS (SMD = −0.31, 95% CI: −0.51, −0.11, I2 = 0%, p = 0.003). While not statistically significant, LVEF decreased (SMD = −0.20, 95% CI: −0.42, 0.03, I2 = 0%, p = 0.09), and left atrial volume index trended higher (SMD = 0.07, 95% CI: −0.14, 0.27, I2 = 0%, p = 0.52) after AC therapy. Conclusions: AC treatment led to reduced LAS and LV GLS values, indicating its potential as an early CTRCD indicator. Larger trials are required to fully explore their clinical significance.
Production of Composite Cement Clinker Based on Industrial Waste
Authors: Kuandykova Aknur , Taimasov Bakhitzhan , Potapova Ekaterina , Sarsenbaev Bakhitzhan , Kolesnikov Alexandr , Begentayev Meiram , Kuldeyev Erzhan , Dauletiyarov Mukhtar , Zhanikulov Nurgali , Amiraliyev Baurzhan , Abdullin Aidana
Published: July 2024

The possibility of producing cement clinker using low-energy, resource-saving technologies is studied. The composition of industrial waste for low-energy-intensive production of Portland cement clinker at factories in Southern Kazakhstan is analyzed. The possibility of replacing the deficient iron-containing corrective additive with “Waelz clinker for zinc ores” is shown. “Waeltz clinker from zinc ores” as part of the raw material charge performs several tasks: it is a ferrous corrective additive, works as a mineralizer for clinker formation processes, introduces coal into the charge and allows one to reduce the consumption of natural fuel. The processes of burning raw mixtures, wholly or partially consisting of industrial waste, are completed at 1350 °C. This reduces the consumption of main burner fuel for clinker burning and reduces CO2 emissions into the atmosphere. High-quality cement clinker is obtained based on raw material mixtures with Waeltz clinker from zinc ores from the Achisai Metallurgical Plant, phosphorus slag, coal mining waste from Lenger mines and sodium fluoride. The phase composition and microstructure of low-energy clinkers are revealed. Involving industrial waste in raw material circulation will reduce environmental pollution and improve the environment.
Effects of the NeuroHAB Program on Low Back Pain and Oswestry Disability Index Scores: A Retrospective Wait-List Control Study
Authors: Williams Brogan , Johnson David
Published: July 2024

Movement theory and the study of movement dysfunction mark a paradigm shift in the treatment of low back pain symptoms, the majority of which are mechanical in origin at the outset. Treating movement dysfunction centers around unified and consistent rehabilitation that defines proficient movement for the lumbopelvic spine. The purpose of this study is to document the improvement in pain and disability of 290 patients who underwent NeuroHAB Functional Movement Therapy to reverse their lumbopelvic movement dysfunction attributed to causing their back pain symptoms between 2019 and 2023. Oswestry Disability Index (ODI) scores were collected from each participant on three occasions: the first consultation, after a waiting period/pre-intervention, and after the eight-week intervention. A single-factor ANOVA of all three ODI data sets was conducted, along with supporting descriptive statistics. A post-hoc t-test pairwise comparison was conducted for accuracy. The average ODI 1 score (taken at the first consultation) was 15.26 ± 6.1% (CI: 14.3–16.2); ODI 2 (after a waiting period, before NeuroHAB) was 14.71 ± 6.0% (CI: 13.82–15.59); and ODI 3 (post-intervention) was 9.09 ± 8.6% (CI: 8.305–9.875). There was no significant change from ODI 1 to ODI 2 (between the consultation and waitlist control periods). However, a significant reduction between ODI 2 and ODI 3 was observed (pre- and post-intervention) (mean difference: 5.62, p ≤ 0.001), and a 40.41% reduction was observed between ODI 1 (the ODI score taken at the first consultation) and ODI 3 (the ODI score taken after NeuroHAB, post-intervention) (mean difference: 6.17, p ≤ 0.001). A 50% ODI reduction was reported in the “Crippled” category (mean difference 16.15, p ≤ 0.001). The inclusion of functional movement proficiency and stability in future guidelines is a necessary step towards meaningful improvement in epidemic levels of back pain-related clinical and economic morbidity.
DICER1 Tumor Syndrome: A Retrospective Review and Future Perspectives
Authors: Cazzato Gerardo , Casatta Nadia , Lupo Carmelo , Ingravallo Giuseppe , Ribatti Domenico
Published: July 2024

DICER1 syndrome, a rare autosomal dominant genetic disorder, stems from mutations in the DICER1 gene, disrupting RNA interference and leading to various tumors. These tumors, affecting organs like the lung, kidney, ovaries, and brain, pose diagnostic challenges due to diverse presentations. Understanding DICER1-associated tumors, including pleuropulmonary blastoma, ovarian Sertoli–Leydig cell tumors, and others, is vital for early detection and management. Surgical resection, chemotherapy, and targeted therapies are primary treatment modalities, with genetic counseling playing a crucial role. Multidisciplinary care is essential for optimal management, offering hope for improved outcomes in affected individuals.
VRAM Versus ALT Flap Reconstruction for Large Head and Neck Defects: Does Weight Influence Complication Rate?
Authors: Shires Courtney B. , Jackson Jataiveus , Moskovitz Jessica , Dewan Karuna
Published: July 2024

Background: Obesity remains a high-level risk factor for various cancers. Yet, some research has shown that higher BMIs may improve survival outcomes, particularly for head and neck squamous cell carcinoma (HNSCC). While this is a clear deviation from the norm, it raises the question of what other effects obesity may have on head and neck cancer patients, including surgical outcomes. Choosing the most appropriate flap for patients can be difficult for even experienced surgeons. Head and neck reconstructive surgeries are no exception to this rule and can be especially challenging. To produce the most favorable outcomes, a physician must be able to combine all flap attributes including donor and recipient site location, flap thickness, as well as each patient’s individual risk factors such as prior radiation. Purpose: The purpose of this study was to compare the outcomes of vertical rectus femoris myocutaneous (VRAM) and anterolateral thigh (ALT) flaps in overweight and obese individuals with varying head and neck cancers leaving large-sized defects to the outcomes in normal and underweight patients. Methods: A retrospective chart review was conducted of VRAM and ALT flaps performed over a period of 12 months at our university hospital for large head and neck reconstruction. Results: Of the 17 ALT patients, 80% (4/5) of the underweight patients, 57% (4/7) of the normal weight patients, 50% (1/2) of the overweight patients, and 33% (1/3) of the obese patients experienced complications. Of the 15 VRAM patients, 40% (2/5) of the underweight patients, 83% (5/6) of the overweight patients, and 50% (1/2) of the obese patients experienced complications. Conclusions: In our small sample size, a smaller percentage of obese patients with head and neck cancer who underwent flap reconstruction surgery had complications when undergoing ALT flaps than VRAM flaps, which contrasts with the normal and underweight patients, who had less complications with VRAM flaps than ALT flaps.
Would Managers Sacrifice Conservative Financial Reporting to Meet/Beat Market Earnings Expectations?
Authors: Ng Anthony C. , Xin Hua Christine , Jaggi Bikki
Published: July 2024

Prior studies show that engaging in conservative financial reporting (CON) positively affects earnings quality. However, managers also manage earnings to meet/beat market earnings expectations (MBME). This study asks three questions regarding the earnings that MBME. First, it investigates whether managers are willing to sacrifice CON when adopting strategies to MBME. Second, it tests whether managers prefer to use other earnings management (EM) strategies to MBME instead of sacrificing CON. Third, it tests whether information asymmetry between managers and shareholders affects managers’ decisions to sacrifice CON. Results show that managers are more likely to sacrifice CON to MBME but are less likely to do so if they can manage earnings using accrual-based or real EM. Also, managers are more likely to do so when information asymmetry with shareholders is higher. These findings contribute to the literature by examining the circumstances in which managers would sacrifice CON to MBME.
The Hellenic Archaeological Cadastre: A Land Administration System Specifically Designed for the Documentation and Management of Cultural Heritage
Authors: Basiouka Sofia
Published: July 2024

How is land management related to cultural policy and how do these two different scientific fields contribute to cultural heritage protection? How may archaeological sites, immovable monuments, and state property be recorded in a specific Land Administration System? What are the records of the system in numbers? These questions will be answered in this publication, and the example of the Hellenic Archaeological Cadastre (HAC) will be analyzed in detail. The HAC project is one of the most important projects that has been designed, implemented, and launched within the last decade by the Hellenic Ministry of Culture. The transition of the whole public sector in the digital era and the urgent need for reliable and updated geospatial documentation of public parcels of land and constructions, archaeological sites, and immovable monuments were the two main factors that led to the compilation and implementation of the specific LAS. This study presents the available tools, administrative procedures, records, qualitative and quantitative data, and prominent examples of public parcels of land accessible online in the open access web GIS platform. A SWOT analysis is also performed for its evaluation.
Productivity, Soil Health, and Tree Diversity in Dynamic Cacao Agroforestry Systems in Ecuador
Authors: Allen Summer L. , Robayo Lenin Alejandro , Martin Carla D. , Ganem José Lopez
Published: July 2024

Agroforestry has the potential to support more resilient livelihoods, soil health, and biodiversity, when compared to monocropping. In Ecuador, the Union of Cacao Peasant Organizations (UNOCACE) has been working with producers since 2016 to transition cacao plots to a dynamic agroforestry system that includes timber and fruit species as well as ground cover in addition to cacao. This study evaluates the application of this model and its implications for agricultural production, livelihoods, and soil health through producer surveys and field-based sampling. The program is resulting in significantly more timber and fruit trees on the cacao plots. Despite this, cacao production and income have not decreased in a significant way, once accounting for the number of producing trees on the plots. In addition, while additional labor is utilized on the dynamic agroforestry plots, after utilizing a matching procedure, no significant difference is seen in total crop productivity for each day of labor utilized. Over time, total productivity could increase for the dynamic agroforestry plots as the companion crops and trees mature. As the program is relatively new and has undergone some changes, additional studies are needed to understand the benefits or challenges, especially for soil health, that might be realized further in the lifespan of the program.
An Improved Method to Identify Built-Up Areas of Urban Agglomerations in Eastern and Western China Based on Multi-Source Data Fusion
Authors: Lu Xiaoyi , Yang Guang , Chen Shijun
Published: July 2024

The rapid urbanization in China has significantly contributed to the vast expansion of urban built-up areas. Precisely extracting and monitoring these areas is crucial for understanding and optimizing the developmental process and spatial attributes of smart, compact cities. However, most existing studies tend to focus narrowly on a single city or on global scale with a single dimension, often ignoring mesoscale analysis across multiple urban agglomerations. In contrast, our study employs GIS and image-processing techniques to integrate multi-source data for the identification of built-up areas. We specifically compare and analyze two representative urban agglomerations in China: the Yangtze River Delta (YRD) in the east, and the Chengdu–Chongqing (CC) region in the west. We use different methods to extract built-up areas from socio-economic factors, natural surfaces, and traffic network dimensions. Additionally, we utilize a high-precision built-up area dataset of China as a reference for verification and comparison. Our findings reveal several significant insights: (1) The multi-source data fusion approach effectively enhances the extraction of built-up areas within urban agglomerations, achieving higher accuracy than previously employed methods. (2) Our research methodology performs particularly well in the CC urban agglomeration. The average precision rate in CC is 96.03%, while the average precision rate in YRD is lower, at 80.33%. This study provides an objective and accurate assessment of the distribution characteristics and internal spatial structure of built-up areas within urban agglomerations. This method offers a new perspective for identifying and monitoring built-up areas in Chinese urban agglomerations.
Spatial Differentiation Characteristics, Driving Mechanisms, and Governance Strategies of Rural Poverty in Eastern Tibet
Authors: Tian Jian , Sui Changqing , Zeng Suiping , Ma Junqi
Published: July 2024

Rural areas in Tibet, with its complex terrain, fragile ecology, and poor facilities, are subject to a combination of social–ecological system elements, facing the typical risks of recurrent, marginal, and potential poverty. At present, the spatial differentiation and driving mechanism of rural spatial poverty risk in Tibet are not clear, which adversely affects the formulation of differentiated and precise governance strategies. Thus, based on the social–ecological system perspective, 967 poor rural villages in eastern Tibet were taken as an example, using intelligent techniques such as random forest, geographic detector, and multi-scale geographically weighted regression to identify the spatial differentiation characteristics and the driving mechanism of poverty. The results indicated that (1) the high poverty incidence of rural areas in eastern Tibet showed a scattered block distribution, of which approximately 37% of the villages presented a spatial distribution characterised by a high degree of clustering of the high poverty incidence. (2) Topography and the level of public facilities were key factors influencing the poverty levels of rural areas in eastern Tibet, in which the coupling explanatory power between the construction land slope index (CLSI) and several poverty-causing factors was high. (3) Geological disaster, land surface temperature, CLSI, traffic accessibility, livestock resources, cropland per capita, and tourism resources differentially drove the poverty incidence of rural areas in eastern Tibet, forming spatial partitions dominated by the risks of potential, marginal, and recurrent poverty. For different partitions, differentiated governance strategies of upgrading ecological environments, optimising geographical locations, and revitalising social resources were proposed to provide references for solving the problem of relative poverty in the new period.
How Do the Home Country Regulations Promote the Responsibility for Overseas Farmland Investment?
Authors: He Wei , Luo Pingping , Lyu Qianxiu , Hu Jian
Published: July 2024

Restricted by economic and social development conditions and the level of domestic regulatory system construction, the traditional host country-centered regulatory approach makes it difficult to ensure “responsible investment” by overseas farmland investment companies. The jury is still out on whether international law can directly impose obligations and responsibilities on companies. Therefore, it is realistically necessary for the investor’s home country to regulate any behavior that infringes on the human rights and environment of residents of the host country during the company’s overseas farmland investment. We used a panel fixed effects model and the dummy variable method to construct regression indicators based on international treaties. This study finds that promulgating responsible investment treaties can significantly promote the scale and number of international farmland investments, which also further led to the problem of differentiation among overseas farmland investors. We further discussed the lack of binding force of current international rules and the difficulty in coordinating the interests of multiple parties. In the regulatory system of the home country, there are still problems, such as insufficient supply of adequate laws, and lack of administrative guidance. Measures such as deepening negotiations on international rules for responsible overseas farmland investment, further leveraging the role of land ownership in responsible overseas farmland investment, improving existing domestic legislation, and strengthening administrative guidance on overseas farmland investment can be used as countermeasures.
Characteristics, Relationships, and Anatomical Basis of Leaf Hydraulic Traits and Economic Traits in Temperate Desert Shrub Species
Authors: Tan Fengsen , Cao Wenxu , Li Xu , Li Qinghe
Published: July 2024

Shrubs are a key component of desert ecosystems, playing a crucial role in controlling desertification and promoting revegetation, yet their growth is often impeded by drought. Leaf hydraulic traits and economic traits are both involved in the process of water exchange for carbon dioxide. Exploring the characteristics, relationships, and anatomical basis of these two suites of traits is crucial to understanding the mechanism of desert shrubs adapting to the desert arid environment. However, the relationship between these two sets of traits currently remains ambiguous. This study explored the leaf hydraulic, economic, and anatomical traits of 19 desert shrub species. The key findings include the following: Relatively larger LT values and smaller SLA values were observed in desert shrubs, aligning with the “slow strategy” in the leaf economics spectrum. The relatively high P50leaf, low HSMleaf, negative TLPleaf, and positive HSMtlp values indicated that severe embolism occurs in the leaves during the dry season, while most species were able to maintain normal leaf expansion. This implies a “tolerance” leaf hydraulic strategy in response to arid stress. No significant relationship was observed between P50leaf and Kmax, indicating the absence of a trade-off between hydraulic efficiency and embolism resistance. Certain coupling relationships were observed between leaf hydraulic traits and economic traits, both of which were closely tied to anatomical structures. Out of all of the leaf traits, LT was the central trait of the leaf traits network. The positive correlation between C content and WPleaf and HSMleaf, as well as the positive correlation between N content and HSMtlp, suggested that the cost of leaf construction was synergistic with hydraulic safety. The negative correlation between SLA, P content, GCL, and SAI suggested a functional synergistic relationship between water use efficiency and gas exchange rate. In summary, this research revealed that the coupling relationship between leaf hydraulic traits and economic traits was one of the important physiological and ecological mechanisms of desert shrubs for adapting to desert habitats.
Myocardial, Valvular and Vascular Abnormalities in Repaired Tetralogy of Fallot
Authors: Nemes Attila
Published: July 2024

Tetralogy of Fallot is the most common heart defect associated with cyanosis characterized by the co-occurrence of pulmonary stenosis, right ventricular hypertrophy, and ventricular septal defect with over-riding of the aorta. The present review purposed to summarize myocardial, valvular and vascular abnormalities, which were described in a series of patients following repair of tetralogy of Fallot. It was also aimed to describe potential differences in these parameter using different surgical strategies.
Abrasive Waterjet Machining
Authors: Hashish Mohamed
Published: July 2024

The abrasive waterjet machining process was introduced in the 1980s as a new cutting tool; the process has the ability to cut almost any material. Currently, the AWJ process is used in many world-class factories, producing parts for use in daily life. A description of this process and its influencing parameters are first presented in this paper, along with process models for the AWJ tool itself and also for the jet–material interaction. The AWJ material removal process occurs through the high-velocity impact of abrasive particles, whose tips micromachine the material at the microscopic scale, with no thermal or mechanical adverse effects. The macro-characteristics of the cut surface, such as its taper, trailback, and waviness, are discussed, along with methods of improving the geometrical accuracy of the cut parts using these attributes. For example, dynamic angular compensation is used to correct for the taper and undercut in shape cutting. The surface finish is controlled by the cutting speed, hydraulic, and abrasive parameters using software and process models built into the controllers of CNC machines. In addition to shape cutting, edge trimming is presented, with a focus on the carbon fiber composites used in aircraft and automotive structures, where special AWJ tools and manipulators are used. Examples of the precision cutting of microelectronic and solar cell parts are discussed to describe the special techniques that are used, such as machine vision and vacuum-assist, which have been found to be essential to the integrity and accuracy of cut parts. The use of the AWJ machining process was extended to other applications, such as drilling, boring, milling, turning, and surface modification, which are presented in this paper as actual industrial applications. To demonstrate the versatility of the AWJ machining process, the data in this paper were selected to cover a wide range of materials, such as metal, glass, composites, and ceramics, and also a wide range of thicknesses, from 1 mm to 600 mm. The trends of Industry 4.0 and 5.0, AI, and IoT are also presented.
Nanoindentation Test of Ion-Irradiated Materials: Issues, Modeling and Challenges
Authors: Ma Hailiang , Fan Ping , Qian Qiuyu , Zhang Qiaoli , Li Ke , Zhu Shengyun , Yuan Daqing
Published: July 2024

Exposure of metals to neutron irradiation results in an increase in the yield strength and a significant loss of ductility. Irradiation hardening is also closely related to the fracture toughness temperature shift or the ductile-to-brittle transition temperature (DBTT) shift in alloys with a body-centered cubic (bcc) crystal structure. Ion irradiation is an indispensable tool in the study of the radiation effects of materials for nuclear energy systems. Due to the shallow damage depth in ion-irradiated materials, the nanoindentation test is the most commonly used method for characterizing the changes in mechanical properties after ion irradiation. Issues that affect the analysis of irradiation hardening may arise due to changes in the surface morphology and mechanical properties, as well as the inherent complexities in nanoscale indentation. These issues, including changes in surface roughness, carbon contamination, the pile-up effect, and the indentation size effect, with corresponding measures, were reviewed. Modeling using the crystal plasticity finite element method of the nanoindentation of ion-irradiated materials was also reviewed. The challenges in extending the nanoindentation test to high temperatures and to multiscale simulation were addressed.
Experimental Investigation of Water Vapor Concentration on Fracture Properties of Asphalt Concrete
Authors: Chen Yu , Huang Tingting , Wen Xuqing , Zhang Kai , Li Zhengang
Published: July 2024

The effect of moisture on the fracture resistance of asphalt concrete is a significant concern in pavement engineering. To investigate the effect of the water vapor concentration on the fracture properties of asphalt concrete, this study first designed a humidity conditioning program at the relative humidity (RH) levels of 2%, 50%, 80%, and 100% for the three types of asphalt concrete mixtures (AC-13C, AC-20C, and AC-25C).The finite element model was developed to simulate the water vapor diffusion and determine the duration of the conditioning period. The semi-circular bending (SCB) test was then performed at varying temperatures of 5 °C, 15 °C, and 25 °C to evaluate the fracture energy and tensile strength of the humidity-conditioned specimens. The test results showed that the increasing temperature and the RH levels resulted in a lower peak load but greater displacement of the mixtures. Both the fracture energy and tensile strength tended to diminish with the rising temperature. It was also found that moisture had a significant effect on the tensile strength and fracture energy of asphalt concrete. Specifically, as the RH level increased from 2% to 100% (i.e., the water vapor concentration rose from 0.35 g/m3 to 17.27 g/m3), the tensile strength of the three types of mixtures was reduced by 34.84% on average, which revealed that the water vapor led to the loss of adhesion and cohesion within the mixture. The genetic expression programming (GEP) model was developed to quantify the effect of water vapor concentrations and temperature on the fracture indices.
Structure and Spectral Properties of Er3+-Doped Bismuth Telluride Near-Infrared Laser Glasses
Authors: Tan Fang , Xie Guoxing , Ma Yuqin , Zhang Yunlong , Gao Binhao , Cui Shunfa , Chen Dexiao , Ban Yumeng , Zhou Dechun
Published: July 2024

TeO2-Bi2O3-B2O3-ZnO laser glasses doped with Er3+ were synthesized through an optimized melt-quenching method. The absorption spectra at 808 nm LD pumping were studied. Various spectral tests and data analyses indicate that the maximum fluorescence emission intensity can be obtained when the Er3+ doping concentration reaches 2%. In this case, the emission cross-section can reach up to 9.12 × 10−21 cm2 and the gain coefficient at 1.55 μm is 6.17 cm−1. Simultaneously, the sample has a lower phonon energy in the high-frequency band at 1077 cm−1, which reduces the probability of non-radiative relaxation. The calculated energy transfer coefficient CD-A is 13.8 × 10−40 cm6/s, reflecting the high cross-relaxation probability of Er3+ in the sample, which promotes the luminescence of 1.55 μm and favors the emission in the near-infrared region. The comprehensive results demonstrate that the prepared Er3+-doped bismuth telluride laser glass can be used as a promising and high-quality gain material for near-infrared lasers.
Enhancing Computation-Efficiency of Deep Neural Network Processing on Edge Devices through Serial/Parallel Systolic Computing
Authors: Moghaddasi Iraj , Nam Byeong-Gyu
Published: July 2024

In recent years, deep neural networks (DNNs) have addressed new applications with intelligent autonomy, often achieving higher accuracy than human experts. This capability comes at the expense of the ever-increasing complexity of emerging DNNs, causing enormous challenges while deploying on resource-limited edge devices. Improving the efficiency of DNN hardware accelerators by compression has been explored previously. Existing state-of-the-art studies applied approximate computing to enhance energy efficiency even at the expense of a little accuracy loss. In contrast, bit-serial processing has been used for improving the computational efficiency of neural processing without accuracy loss, exploiting a simple design, dynamic precision adjustment, and computation pruning. This research presents Serial/Parallel Systolic Array (SPSA) and Octet Serial/Parallel Systolic Array (OSPSA) processing elements for edge DNN acceleration, which exploit bit-serial processing on systolic array architecture for improving computational efficiency. For evaluation, all designs were described at the RTL level and synthesized in 28 nm technology. Post-synthesis cycle-accurate simulations of image classification over DNNs illustrated that, on average, a sample 16 × 16 systolic array indicated remarkable improvements of 17.6% and 50.6% in energy efficiency compared to the baseline, with no loss of accuracy.
Influence of High-Temperature Deformation on the Dissolution of δ-Ferrite in Stainless Steels
Authors: Bajmalu Rostami Rahman , de Souza Ciacco Pedro , Viali Muñoz Mauricio Claudio , Simoes Luis Fellipe , Garcia Calixto Isaac
Published: July 2024

The dissolution behavior of δ-ferrite in two commercial stainless steels, 15-5PH and M-154, was studied. In this work, a new approach combining hot deformation and additional post-treatment was investigated and compared with conventional annealing heat treatments for the dissolution of δ-ferrite. The results showed the acceleration in the dissolution of δ-ferrite using the new methodology. Samples from each steel were subjected to conventional annealing heat treatments at 1000 °C and 1150 °C, with soaking times of 1, 2, and 3 h. A second set of samples was subjected to hot compression experiments at 900 °C, under different strain rates, followed by post-processing heat treatments at 1000 °C and 1150 °C, while keeping the holding time constant for 10 min. Advanced microstructural characterization techniques such as Scanning Electron Microscopy (SEM), and Electron Probe Micro-Analysis (EPMA) were employed to investigate δ-ferrite dissolution in terms of changes in area fraction and chemical composition. The results indicated a strong correlation between the dissolution behavior of δ-ferrite and the processing parameters. In addition, thermodynamic calculations using Thermo-Calc software (version 2021.2.87071-368) were used to assess the diffusion of elements during the dissolution of δ-ferrite as a function of temperature and time.
Editorial for the Special Issue on Photonic Chips for Optical Communications
Authors: Xu Jing , Pu Minhao
Published: July 2024

In this era of data explosion, optical communications have endowed the digital world with the capability for high-speed, large-capacity data flow transmission [...]
Porous CuO Microspheres as Long-Lifespan Cathode Materials for Aqueous Zinc-Ion Batteries
Authors: Ai Yuqing , Pang Qiang , Liu Xinyu , Xin Fangyun , Wang Hong , Xing Mingming , Fu Yao , Tian Ying
Published: July 2024

Cathode materials with conversion mechanisms for aqueous zinc-ion batteries (AZIBs) have shown a great potential as next-generation energy storage materials due to their high discharge capacity and high energy density. However, improving their cycling stability has been the biggest challenge plaguing researchers. In this study, CuO microspheres were prepared using a simple hydrothermal reaction, and the morphology and crystallinity of the samples were modulated by controlling the hydrothermal reaction time. The as-synthesized materials were used as cathode materials for AZIBs. The electrochemical experiments showed that the CuO-4h sample, undergoing a hydrothermal reaction for 4 h, had the longest lifecycle and the best rate of capability. A discharge capacity of 131.7 mAh g−1 was still available after 700 cycles at a current density of 500 mA g−1. At a high current density of 1.5 A g−1, the maintained capacity of the cell is 85.4 mA h g−1. The structural evolutions and valence changes in the CuO-4h cathode material were carefully explored by using ex situ XRD and ex situ XPS. CuO was reduced to Cu2O and Cu after the initial discharge, and Cu was oxidized to Cu2O instead of CuO during subsequent charging processes. We believe that these findings could introduce a novel approach to exploring high-performance cathode materials for AZIBs.
Xc- System as a Possible Target for ConBr Lectin Interaction in Glioma Cells
Authors: Pinto-Junior Vanir Reis , Seeger Rodrigo Lopes , Souza-Filho Cláudio Henrique Dahne , França Angela Patricia , Sartori Nicole , Oliveira Messias Vital , Osterne Vinicius Jose Silva , Nascimento Kyria Santiago , Leal Rodrigo Bainy , Cavada Benildo Sousa
Published: July 2024

Studies have revealed the dependence of glioma cells on iron, making them sensitive to ferroptosis. Ferroptosis can be triggered by inhibition of the xc- system, resulting in redox imbalance and membrane lipid peroxidation. The xc- system is composed of two coupled proteins, xCT and CD98hc. The control of transporters, such as xCT, by the CD98hc glycoprotein suggests that molecules targeting glycans may have an impact on the treatment of glioma. This study evaluated the effect of the Canavalia brasiliensis (ConBr) lectin on C6 glioma cells and compared it with erastin, an xc- system inhibitor. Both induced dose-dependent cell death, accompanied by an increase in the production of reactive oxygen species and a decrease in reduced glutathione. However, co-treatment did not show an additive effect. The analysis was updated by molecular dynamics assessments of the xc- system interacting with ConBr or erastin. The interaction of erastin with the xc- system affects its interaction with ConBr, reducing the antagonistic effect when both are in the protein complex. The data show that ConBr is effective in inducing cell death in glioma cells and regulates the xc system through interaction with CD98hc glycans, showing that lectins have the potential to promote ferroptosis in glioma cells.
Correction: Micheli et al. Treatment of Non-Alcoholic Steatosis: Preclinical Study of a New Nutraceutical Multitarget Formulation. Nutrients 2020, 12, 1819
Authors: Micheli Laura , Pacini Alessandra , Di Cesare Mannelli Lorenzo , Trallori Elena , D’Ambrosio Roberta , Bianchini Carlo , Lampertico Pietro , Ghelardini Carla
Published: July 2024

In the original publication [...]
A Comparison between the Production of Edible Macroalgae Worldwide and in the Mediterranean Sea
Authors: Jelić Mrčelić Gorana , Krstulović Šifner Svjetlana , Nerlović Vedrana
Published: July 2024

Macroalgae are beneficial for consumers and producers due to their high productivity, their chemical composition and their efficient cultivation without additional feed. Asia dominates global macroalgae production, while European production is still marginal and mainly based on wild harvesting in the North Atlantic. The European Commission has launched initiatives to promote the sustainable production, safe consumption and innovative use of macroalgae products in European regional seas, including the Mediterranean Sea. A variety of coastal and seabed types and a wide range of environmental conditions make the Mediterranean a hotspot of marine biodiversity while providing good conditions for the cultivation of macroalgae. The aim of this paper is to compare the global macroalgae production and macroalgae production in the Mediterranean Sea, focussing on the cultivation of edible macroalgae. The paper also discusses the limitations and possibilities of macroalgae production in the region. Macroalgae production is one of the most promising sectors of the blue economy in the Mediterranean. The production of edible macroalgae suitable for human consumption has great potential, considering future population growth and related food security and health issues, as well as the additional ecosystem benefits of macroalgae production.
Does the Oxygen Functionality Really Improve the Thermodynamics of Reversible Hydrogen Storage with Liquid Organic Hydrogen Carriers?
Authors: Verevkin Sergey P. , Samarov Artemiy A. , Vostrikov Sergey V.
Published: July 2024

Liquid organic hydrogen carriers (LOHCs) are aromatic molecules that are being considered for the safe storage and release of hydrogen. The thermodynamic properties of a range of aromatic ethers were investigated using various experimental and theoretical methods to assess their suitability as LOHC materials. The absolute vapour pressures were measured for benzyl phenyl ether, dibenzyl ether and 2-methoxynaphthalene using the transpiration method. The standard molar enthalpies and entropies of vaporisation/sublimation were derived from the temperature dependence of the vapour pressures. The combustion energies of benzyl phenyl ether and dibenzyl ether were measured using high-precision combustion calorimetry, and their standard molar enthalpies of formation were derived from these data. High-level quantum chemical calculations were used to calculate the standard molar enthalpies of formation in the gas phase for benzyl phenyl ether, dibenzyl ether and 2-methoxynaphthalene. The latter values agreed very well with the experimental results obtained in this work. The thermodynamic properties of the hydrogenation/dehydrogenation reactions in liquid phase in LOHC systems based on methoxy–benzene, diphenyl ether, benzyl phenyl ether, dibenzyl ether and 2-methoxynaphthalene were derived and compared with the data for similarly structured hydrogen carriers based on benzene, diphenylmethane, 1,2-diphenylethane, 1,3-diphenylpropane and naphthalene. The influence of the oxygen functionality on the thermodynamic properties of the hydrogenation/dehydrogenation reactions was evaluated.
Diagnostic Utility of N-Terminal Pro-B-Type Natriuretic Peptide in Identifying Atrial Fibrillation Post-Cryptogenic Stroke: A Systematic Review and Meta-Analysis
Authors: Patel Jay , Bhaskar Sonu M. M.
Published: July 2024

Background: Atrial fibrillation (AF) significantly contributes to acute ischemic stroke, with undetected AF being a common culprit in cryptogenic strokes. N-terminal pro-B-type natriuretic peptide (NT-proBNP), indicative of myocardial stress, has been proposed as a biomarker for AF detection, aiding in the selection of patients for extended cardiac monitoring. However, the diagnostic accuracy of NT-proBNP remains uncertain. Methods: We conducted a meta-analysis to evaluate the diagnostic accuracy of NT-proBNP in detecting AF among cryptogenic stroke patients. A comprehensive literature search was conducted across PubMed, Embase, and Cochrane databases to identify relevant studies. Studies reporting NT-proBNP levels in stroke patients and data on the proportion of patients with AF above a specified cut-off were included. Meta-analyses were performed using the midas command in STATA. Results: Seven studies encompassing 2171 patients were included in the analysis, of which five studies contained cohorts with cryptogenic strokes. Among patients with cryptogenic stroke, NT-proBNP demonstrated a diagnostic accuracy of 80% (Area Under the Receiver Operating Curve 0.80 [95% CI 0.76–0.83]), with a sensitivity of 81% (95% CI 0.68–0.89) and a specificity of 68% (95% CI 0.60–0.75). Conclusion: Our meta-analysis indicates that NT-proBNP exhibits a good-to-very-good diagnostic accuracy for detecting AF in patients with cryptogenic stroke. These findings suggest potential implications for utilizing NT-proBNP in guiding the selection of patients for prolonged cardiac monitoring, thereby aiding in the management of cryptogenic stroke cases.
Antiproliferative Effect of 7-Ketositosterol in Breast and Liver Cancer Cells: Possible Impact on Ceramide, Extracellular Signal-Regulated Kinases, and Nuclear Factor Kappa B Signaling Pathways
Authors: Barut Zerrin , Aslan Mutay , Çırçırlı Bürke , Çeker Tuğçe , Yılmaz Çağatay
Published: July 2024

Background: This study aimed to examine the effect of 7-Ketositosterol (7-KSS), on sphingomyelin/ceramide metabolites and apoptosis in human breast MCF-7 and human liver HepG2 cancer cells. Methods: Anti-proliferative effects of 7-KSS treatment were assessed at different concentrations and periods. Cell viability was assessed through MTT analysis, whereas the levels of sphingosine-1-phosphate (S1P), sphingomyelins (SMs), and ceramides (CERs) were measured using LC-MS/MS. Phosphorylated 44/42 ERK1/2 and NF-κB p65 (Ser536) protein levels were measured by Western blot analysis and immunofluorescence staining. Apoptosis was evaluated by TUNEL staining and flow cytometric assessment of annexin-V and propidium iodide (PI) labeling. Results: Treatment with 7-KSS significantly decreased cell survival and S1P, p-44/42 ERK1/2, and p-NF-κB p65 protein levels in cancer cells compared to controls. A substantial rise was detected in intracellular amounts of C16-C24 CERs and apoptosis in cancer cells incubated with 7-KSS. Conclusions: 7-KSS stimulated ceramide accumulation and apoptosis while decreasing cell proliferation via downregulating S1P, p-44/42 ERK1/2, and p-NF-κB p65 protein levels.
Nalbuphine Potentiates Reversal of Fentanyl Overdose by Naloxone
Authors: Cernea Mihai , Nikonov Georgiy , Ataiants Janna , Ştefănuţ Cristina , Abernethy John , Voronkov Michael
Published: July 2024

Developing an effective antidote for fentanyl-induced overdose to achieve timely reversal is an unmet public health need. Previously, we found that naloxone derivative NX90 with mild κ-opioid agonistic properties was three-fold more effective than the parent naloxone in reversing a fentanyl overdose in rats. To investigate whether κ-agonistic properties could indeed augment the robustness of overdose reversal, we evaluated a κ-agonist/µ-antagonist nalbuphine (NB) as well as its combinations with naloxone (NX) in a fentanyl overdose model in rodents. An administration of either NB or NX as single agents at 0.1 mg/kg doses produced a full recovery in 90 ± 9.9 min and 11.4 ± 2.7 min, respectively. A higher dose of NX at 0.2 mg/kg reversed an overdose within 4.8 ± 1.0 min. In contrast to that, the coadministration of NB and NX at 0.1 mg/kg each produced a synergistic effect, with overdose reversal in 3.4 ± 0.2 min. The coadministration of NX and NB at sub-therapeutic doses of 0.05 mg/kg each was also 1.2-fold more effective than NX at 0.2 mg/kg. We further found that co-administration of NB at different doses (0.025, 0.05, 0.1 mg/kg) and ratios (1:4 and 1:1) with NX had differential effects on overdose reversal, cardiorespiratory liabilities, and analgesia.
Research on the Mechanism and Material Basis of Corn (Zea mays L.) Waste Regulating Dyslipidemia
Authors: Wang Xiaodong , Cao Lewei , Tang Jiajun , Deng Jiagang , Hao Erwei , Bai Gang , Tang Pei Ling , Yang Jieyi , Li Huaying , Yao Lihao , He Cuiwei , Hou Xiaotao
Published: July 2024

Corn (Zea mays L.) is an essential gramineous food crop. Traditionally, corn wastes have primarily been used in feed, harmless processing, and industrial applications. Except for corn silk, these wastes have had limited medicinal uses. However, in recent years, scholars have increasingly studied the medicinal value of corn wastes, including corn silk, bracts, husks, stalks, leaves, and cobs. Hyperlipidemia, characterized by abnormal lipid and/or lipoprotein levels in the blood, is the most common form of dyslipidemia today. It is a significant risk factor for atherosclerosis and can lead to cardiovascular and cerebrovascular diseases if severe. According to the authors’ literature survey, corn wastes play a promising role in regulating glucose and lipid metabolism. This article reviews the mechanisms and material basis of six different corn wastes in regulating dyslipidemia, aiming to provide a foundation for the research and development of these substances.
From Drug Discovery to Drug Approval: A Comprehensive Review of the Pharmacogenomics Status Quo with a Special Focus on Egypt
Authors: Elgarhy Fadya M. , Borham Abdallah , Alziny Noha , AbdElaal Khlood R. , Shuaib Mahmoud , Musaibah Abobaker Salem , Hussein Mohamed Ali , Abdelnaser Anwar
Published: July 2024

Pharmacogenomics (PGx) is the hope for the full optimization of drug therapy while minimizing the accompanying adverse drug events that cost billions of dollars annually. Since years before the century, it has been known that inter-individual variations contribute to differences in specific drug responses. It is the bridge to what is well-known today as “personalized medicine”. Addressing the drug’s pharmacokinetics and pharmacodynamics is one of the features of this science, owing to patient characteristics that vary on so many occasions. Mainly in the liver parenchymal cells, intricate interactions between the drug molecules and enzymes family of so-called “Cytochrome P450” occur which hugely affects how the body will react to the drug in terms of metabolism, efficacy, and safety. Single nucleotide polymorphisms, once validated for a transparent and credible clinical utility, can be used to guide and ensure the succession of the pharmacotherapy plan. Novel tools of pharmacoeconomics science are utilized extensively to assess cost-effective pharmacogenes preceding the translation to the bedside. Drug development and discovery incorporate a drug-gene perspective and save more resources. Regulations and laws shaping the clinical PGx practice can be misconceived; however, these pre-/post approval processes ensure the product’s safety and efficacy. National and international regulatory agencies seek guidance on maintaining conduct in PGx practice. In this patient-centric era, social and legal considerations manifest in a way that makes them unavoidable, involving patients and other stakeholders in a deliberate journey toward utmost patient well-being. In this comprehensive review, we contemporarily addressed the scientific leaps in PGx, along with various challenges that face the proper implementation of personalized medicine in Egypt. These informative insights were drawn to serve what the Egyptian population, in particular, would benefit from in terms of knowledge and know-how while maintaining the latest global trends. Moreover, this review is the first to discuss various modalities and challenges faced in Egypt regarding PGx, which we believe could be used as a pilot piece of literature for future studies locally, regionally, and internationally.