bluuebunny/crossref_metadata_2025 huggingface dataset:
Doxorubicin-induced neurotoxicity differently affects the hippocampal formation subregions in adult mice
Authors: Dias-Carvalho Ana , Ferreira Mariana , Reis-Mendes Ana , Ferreira Rita , Bastos Maria Lourdes , Fernandes Eduarda , Sá Susana Isabel , Capela João Paulo , Carvalho Félix , Costa Vera Marisa
Published: November 2022

Doxorubicin (DOX) is an anthracycline used to treat a wide range of tumours. Despite its effectiveness, it is associated to a long range of adverse effects of which cognitive deficits stand out. The present study aimed to assess the neurologic adverse outcome pathways of two clinically relevant cumulative doses of DOX. Adult male CD-1 mice received biweekly intraperitoneal administrations for 3 weeks until reaching cumulative doses of 9 mg/kg (DOX9) or 18 mg/kg (DOX18). Animals were euthanized one week after the last administration, and biomarkers of oxidative stress and brain metabolism were evaluated in the whole brain. Coronal sections of fixed brains were used for specific determinations on the prefrontal cortex (PFC) and hippocampal formation (HF). In the whole brain, DOX18 tended to disrupt the antioxidant defences, affecting glutathione levels and manganese superoxide dismutase (MnSOD) expression. Considering the regional analysis, DOX18 increased the volume of all brain areas evaluated, while GFAP-immunoreactive astrocytes decreased in the dentate gyrus (DG) and increased in the CA3 region of HF both in a dose-dependent manner. Concerning apoptosis pathway, whereas Bax increased in the DOX9 group, it decreased in the DOX18 group, but only in the latter group, Bcl-2 levels also decreased. While p53 only increased in the CA3 region of the DOX9 group, AIF increased in the PFC and DG of DOX18. Finally, phosphorylation of Tau decreased with the highest DOX dose in DG and CA3, while TNF-α levels increased in CA1 of DOX18. Our results indicate new pathways not yet described that could be responsible for the cognitive impairments observed in treated patients.
Differentials in deaths of despair in Brazilian subpopulations: a joinpoint regression analysis from 2000 to 2020
Authors: Carvalho Wellington Roberto Gomes , Guimarães Raphael Mendonça
Published: November 2022

Purpose: The death rate from despair is rising among middle-aged non-Hispanic whites with low education and income in the United States. It is unclear whether these trends are the same in different economic contexts. The study's objective is to analyze the temporal trend in the rates of deaths due to despair in Brazil from 2000 to 2020 according to race, sex, and age group.
Methods: We used data stratified by sex, race, and age groups from the Brazilian Mortality Information System. We used joinpoint regression analysis to identify trends in death rates.
Results: Between 2000 to 2020, deaths due to despair increased in all age groups, races, and genders. There was an overall increase of 86.9%. Regarding the speed of increase, we observed that gains are more accelerated in middle-aged groups (mainly between 50 and 59 years old), primarily among black men (AAPC 0.54%, CI 95% 0.41% – 0.68%). The risk persists in these categories during all the time series (Range for RR: man vs women = 5.6 – 6.2; 50-59 yrs vs. 20 – 29 yrs = 1.9 – 2.2; black x white people = 1.1 – 1.6)
Conclusions: Trend analysis of subpopulations indicates that some groups, such as black and brown people, men, and middle-aged age groups, are more sensitive to adverse living conditions. The result, different from the pioneering study in the USA, suggests that the context is differential in explaining the volume and trend of deaths.
Engineering correlated insulators in bilayer graphene with a remote Coulomb superlattice
Authors: Wang Feng , Zhang Zuocheng , Xie Jingxu , Zhao Wenyu , Sanborn Collin , Wang Shaoxin , Kahn Salman , Watanabe Kenji , Taniguchi Takashi , Zettl Alex , Crommie Michael
Published: November 2022

Electron superlattices provide a powerful way to engineer novel correlated and topological quantum phenomena. Originally lithographic-patterned gate arrays were designed to create periodic superlattices in two-dimensional electron gases (2DEGs), where the superlattice potential can be continuously varied electrically. Fabricating superlattices at the nanometer scale with high precision, however, is challenging lithographically. Recently, moiré patterns in 2D materials have been found to offer near-perfect nanometer-scale electronic superlattices, which led to discoveries of exciting quantum phenomena in a variety of moiré heterostructures. However, the requirement of the moiré pattern poses a stringent limit on the material selection, and the moiré potential is not tunable for a given moiré heterostructure. To better engineer novel quantum phases, it will be desirable to create superlattices that combine the advantages of these two methods. Here we achieve this goal by engineering tunable correlated states in bilayer graphene with a remote Coulomb superlattice. The Coulomb superlattice is realized by localized electrons in a twisted bilayer WS2 that are 3 nm above the bilayer graphene. The period of the Coulomb superlattice is determined by the moiré period of the twisted bilayer WS2, and the strength of the superlattice potential is controlled by the number of localized electrons at the twisted bilayer WS2 moiré lattice site. We demonstrate that the 2DEG in encapsulated bilayer graphene is described by the Fermi liquid when the remote Coulomb superlattice is turned off. Electron correlation increases dramatically when the remote Coulomb superlattice is turned on, resulting in a series of correlated insulating states at both integer and fractional filling factors. This remote Coulomb superlattice can be applied to any 2D materials hosting a 2DEG. It opens a new route for in-situ control of correlated quantum phenomena in a wide variety of 2D systems.
Bevacizumab biosimilar candidate TAB008 compared to Avastin ® in patients with locally advanced, metastatic EGFR wild-type non-squamous non-small cell lung cancer: a randomized, double-blind, multicenter study
Authors: Lu S. , Qin S. , Zhou Z. , Chen J. , Gu K. , Sun P. , Pan Y. , Yu G. , Ma K. , Shi J. , Sun Y. , Yang L. , Chen P. , Liu A. , He J.
Published: November 2022

Background:
Bevacizumab(Avastin®) is a monoclonal antibody targeting the vascular endothelial growth factor (VEGF). Used alone or in combination with chemotherapy and/or immunotherapy, bevacizumab has shown promising efficacy in many cancers. This study compared the efficacy and safety of TAB008 with bevacizumab(Avastin®) sourced from the EU (bevacizumab-EU), in patients with non-squamous non–small cell lung cancer (nsNSCLC).
Method:
In this randomized, double-blind, multicenter, phase III similarity study, treatment naive, EGFR wild-type, locally advanced, metastatic, or recurrent non-squamous, non-small cell, lung cancer (ns-NSCLC) patients were enrolled and randomized (1:1) into TAB008 or Bevacizumab-EU groups. Patients received TAB008 or bevacizumab-EU 15 mg/kg intravenously plus paclitaxel/carboplatin for 4-6 cycles followed by TAB008 or bevacizumab-EU 7.5 mg/kg until disease progression, unacceptable toxicity or death. The primary endpoint compared the objective response rate (ORR) within 6 cycles as read by an independent radiological review committee (IRRC). Secondary endpoints compared disease control rate (DCR) Within 6 cycles, duration of response (DoR), progression free survival (PFS), a year overall survival rate (OSR), overall survival (OS), safety, immunogenicity, and steady state pharmacokinetics.
Results:
A total of 549 nsNSCLC patients were enrolled (277 in TAB008 group and 272 in Avastin® group). In the full analysis set, ORRs were 55.957% for TAB008 and 55.720% for Avastin®, the ORR ratio was 1 (90% CI 0.89-1.14), well within the predefined equivalence margin of 0.75 to 1.33. No significant differences were found in DCR within 6 cycles（95.703% vs 95.367%, p=0.8536）, DoR (8.17 vs 7.3 months, p=0.3526), PFS (9.10 vs. 7.97 months, p=0.9457), 1 year overall survival rate (66.2% vs 68%, p=0.6793), or OS (20.4 vs 17.6 months, p=0.6549). Serious adverse events (SAEs) occurred in 37.55% (104/277) of patients in the TAB008 group and 34.32% (93/271) in the Avastin® group. Anti-drug antibodies were reported in 3 of 277(1.08%) TAB008 patients, and 5 of 271(1.85%) Avastin® patients, neutralizing antibody (Nab) was positive in 1 patient on Avastin®, which became negative upon follow-up. The steady-state trough concentrations (Cssmin) were 106.13μg/mL in TAB008 group and 96.03μg/mL in Avastin® groups, with the treatment group ratio of LS geometric means fully contained within the bioequivalence limits of 80.00–125.00% (90% CI was 101.74%-120.05%).
Conclusions:
TAB008 is similar to bevacizumab-EU in terms of efficacy, safety, and pharmacokinetic parameters, with comparable immunogenicity.
ClinicalTrials.gov number, NCT05427305）
Combined effects of Vitamin D and neferine on the progression and metastasis of Colorectal cancer
Authors: Yang Jinfeng , Zhang Qinyu , Huang Guanlin , Cong Jiacheng , Wang Ting , Zhai Xiaoya , Zhang Juzheng , Qi Guangying , Zhou Lihua , Jin Jiamin
Published: November 2022

Purpose
To investigate the synergistic effect of Vitamin D and neferine on colorectal cancer (CRC) growth and metastasis.
Methods
First, the biologically active form of vitamin D, VD3 was conducted to investigate significant synergistic effect with neferine on CRC treatment by bliss analysis. Next, the colony formation and wound healing ability, the migration and invasion ability, the epithelial mesenchymal transition of HCT-116 cells under combination treatment of VD3 and neferine were assessed.
Results
VD3 and neferine showed synergistic effect on CRC cell growth both in a relatively low dose. The wound healing and colony formation ability, cell migration and invasion abilities were all decreased by combination use of VD3 and neferine, in comparing with VD3 or Neferine single treated group. Moreover, VD3 and Neferine significantly decreased N-cadherin, vimentin, Snail and Slug expressions in HCT-116 cells.
Conclusion
These data suggest that neferine enhances the anticancer capability of VD3 and reduces VD3 dose dependency. Combination of Vitamin D with neferine seems to be a potential therapeutic strategy for CRC.
Study of a warfare differential game via dynamic programming approach
Authors: BOUREMANI Touffik , SLIMANI Yacine
Published: November 2022

We use some recent developments in Dynamics Programming Method to obtain the complete and theoretically justified solution of a differential game formulated and studied in \cite{CHE} using the Lanchester equation. We use a certain refinement of Cauchy's Method of characteristics for stratified Hamilton-Jacobi equations to describe a large set of admissible trajectories and identify a domain on which the value function exists and is generated by a pair of admissible feedback strategies. Its optimality, is justified by using of one of the well-known verification theorems as an argument for sufficient optimality conditions.
MSC Classification: 49N70 , 49N35 , 49N90 , 91A23 , 49L20 , 34A60
Urban scaling of cities in Israel
Authors: Yatzkan Or Nissim , Omer Itzhak , Burg David
Published: November 2022

Cities have been shown to exhibit empirical scaling behavior where numerous variables of urban performance are allometric, like greenhouse gas emissions. Polluting emissions have negative environmental and health impacts. Therefore, recently, this methodology of urban scaling has been implemented to study the dynamics of vehicle and industrial emissions into the environment. It has been shown that cities may be environmentally efficient with CO2 emissions that seem to be sublinear, so the large cities may be more "green". However, a number of reports suggest a superlinear relationship with respect to population size, so the large cities may be less "green". We report here the results of the nonlinear allometric power-law scaling properties of multiple air pollutants in the Israel urban system, expanding the analysis to include electricity consumption and atmospheric emissions of CO2, NOx, SO2, CO, NMVOC, PM10, PM2.5, benzene and 1,3-butadiene. The results show the recurring mathematical patterns of cities similar to those reported elsewhere. Electricity usage is superlinear. Pollutant emissions of these greenhouse gases tend to exhibit significant superlinear dynamics (β > 1), though NMVOC and Benzene were linear. The superlinear result was conserved when regressing against the number of vehicles. This evidence supports the hypothesis that large cities may be less "green". Indeed, different urban characteristics such as geography, local climate and weather conditions, population density, may also affect the pollution levels of cities. Taken together these results give evidence to the effect of urban agglomerations on the environment. With this perspective it may be possible to implement sustainable policy to improve the environment and increase human wellbeing.
Determination of Mold Diversity of Some Fruits Sold in Eastern Turkey
Authors: GHİMİRE Dipak , ERDOĞAN Ahmet , BARAN Alper , GÜRSES Mustafa , MERAL AKTAŞ Hacer
Published: November 2022

Fungi that contaminate the fruits at stages such as ripening, harvesting, storage, transportation may cause deterioration and economic losses, and even some strains can produce mycotoxins known to be harmful to health. In this respect, it was examined that the mold diversity of some fruits sold in eastern Turkey. A total of 113 different fruits, both non-moldy and moldy, were collected and 395 strains were isolated and identified using classical methods from different parts of the fruits (surfaces, core cavities and rotten parts). It was found the 11 different genera of fungi including Penicillium spp. (34.43%), Cladosporium spp. (22.53%), Rhizopus spp. (21.01%), Alternaria spp. (8.10%), Botrytis spp. (7.34%), Aspergillus spp. (2.27%), Byssochlamys spp. (1.52%), Acremonium spp. (0.76%), Fusarium spp. (0.76%), Colletotrichum spp. (0.76%), and Geotrichum spp. (0.51%) in the analysed strawberry, grape, apple, cherry, pear, plum, pomegranate, apricot, peach, orange, tangerine, and quince fruits. It is noteworthy that the fungi known to produce mycotoxins such as Penicillium expansum and Penicillium italicum are among the fungi isolated within the scope of the study.
Defektif Homolog Rekombinasyon DNA Tamiri ve PARP İnhibisyonu Arasındaki Sentetik Letal Etkileşim
Authors: TOY Yusuf , GUNDOGDU Ramazan , SEVER Aydın , ERDOĞAN Mehmet Kadir
Published: November 2022

İnsan hücreleri endojen ve eksojen nedenlerle oluşan genomik hasarlara karşı kompleks bir DNA hasar yanıt
mekanizmasına sahiptir. Hücreler, DNA hasar yanıt işlevsizliği durumunda onarılmadıklarından genom stabilitesini tehdit
eden çeşitli DNA lezyonlarını biriktirmeye başlar. Yetersiz DNA hasar yanıt aktivitesi; neoplastik transformasyona, antikanser ilaç direncine ve ilgili tedaviler neticesinde oluşan ciddi yan etkilere neden olmanın yanı sıra, tedavi yanıtının
tahmininde kullanılabilir bir biyogösterge veya kanser hücrelerini mevcut tedavilere karşı daha duyarlı hale getirebilecek
farmakolojik bir hedef olarak da kullanılabilmektedir. Poli (ADP-riboz) (PARP) enzimleri, DNA tek zincir kırıklarının
onarılması dahil birçok hücresel mekanizmada rol oynamaktadır. BRCA1/2 proteinleri ise DNA çift zincir kırıklarının
homolog rekombinasyon yolağıyla tamir edilmesinde görev almaktadır. Yapılan çalışmalar, BRCA1/2 mutasyonu
neticesinde homolog rekombinasyon defektif hale gelen hücrelerin PARP inhibitörlerine karşı hassasiyet kazandığı
göstermiştir. BRCA1/2 ve PARP arasında tanımlanan söz konusu sentetik letal etkileşimin başarılı klinik uygulaması,
araştırmacıları homolog rekombinasyon durumunu bildirecek farklı biyogöstergeleri araştırmaya ve PARP inhibitör
direncinin üstesinden gelmek için diğer potansiyel sentetik letal etkileşimleri ortaya çıkarmaya yönlendirmiştir. Bu
derlemede öncelikle DNA hasar yanıt yolağının mevcut durumu özetlenmiş, sonrasında HR tamir sistemi ve PARP
inhibisyonu arasındaki sentetik letalite anlatılmıştır.
Iğdır ili arazi kullanımı/örtü değişiminin Corine izlemesi ile değerlendirilmesi
Authors: KARAOĞLU Mücahit , ERDEL Erhan
Published: November 2022

Arazi kullanımı/örtü (AK/AÖ) değişimlerinin milli ve milletlerarası seviyede doğru olarak izlenmesine, analizine ve hesaplanmasına imkân veren, uzaktan algılama (UA) ve coğrafi bilgi sistemlerinden (CBS) yararlanan yeni dijital veri kümeleri kullanımı yaygınlaşmıştır. Bu dijital veri kümelerinden birisi Avrupa ölçekli çevre ile ilgili veri elde etme görevini yürüten Avrupa Çevre Ajansı’nın (European Environment Agency-EEA) yöntemini geliştirdiği ve Türkiye’nin de dahil olduğu 39 ülke tarafından kullanılan CORINE izleme sistemidir. Bu çalışmada Çevresel Bilgi Koordinasyonu (Coordination of Information on the Environment-CORINE) izleme yöntemine göre Iğdır ili için 2000-2006-2012-2018 yıllarında arazi kullanımı/örtü mevcut durumu ve meydana gelen değişikliklerin alan ve oran olarak hesaplanması, değişimin sebeplerinin belirlenmesi hedeflenmiştir. Iğdır ili için CORINE yöntemine göre; AK/AÖ çeşitleri 1. düzeyde yer alan 5 ana başlık altında (yapay yüzeyler, tarım alanları, ormanlık ve doğal alanlar, sulak alanlar ve su kütleleri), 2. düzeyde 12 ve 3. düzeyde 23 farklı izleme sınıfı olarak belirlenmiştir. Bu sınıfların her altı yıllık dönemi için alansal ve oransal hesaplamaları yapılarak 2000-2018 döneminde arazi kullanımı/örtü durumundaki değişimler, yapay yüzeylerde 358.9 ha, tarım alanlarında 1850.8 ha, su kütlelerinde 18.5 ha artış; ormanlık ve doğal alanlarda 2187.9 ha, sulak alanlarda 153.6 ha azalış olarak belirlenmiştir. İl arazisi üzerinde en yaygın arazi kullanımı/örtü sınıfını (16407.6 ha) ve artışını (4165.6 ha), seyrek bitki örtüsü ile kaplı eğimli, sığ ve düşük verimli alanlar oluşturmaktadır.
Effects of Different Power Levels Used in Microwave Drying Method on Color Changes of Oyster Mushroom (Pleurotus Ostreatus)
Authors: ALTIKAT Sefa , ALMA Mehmet Hakkı , GULBE Alper , KÜÇÜKERDEM Kaan , KUŞ Emrah
Published: November 2022

Color of dried edible material is one of the most essential considerations for consumers when making product purchases. The similarity between the color of the dried product and the color of the fresh product increases their marketability. The primary objective of drying operations is to dry products with minimal energy consumption, to prevent the growth of microorganisms, preserve their flavor and nutritional value, to make the moisture content suitable for storage, and to ensure that the color change after drying closely resembles that of the fresh product. This study seeks to dry Oyster mushrooms (Pleurotus spp.) at different drying power levels (90 W, 180 W, 360 W, and 600 W) using the microwave drying method of thin slices and to determine the color changes of the dried mushrooms. As a result of the trials carried out in the laboratory, it was discovered that the increase in drying power caused the samples to dry faster. At the end of the drying period, the colors of the mushrooms became darker than the initial levels. The highest change in brightness was recorded during the drying process at a power of 90 W. In the investigation, it was determined that the drying time was longer and the color change of the dried product was greater when the power was 90 W. Based on this, it can be stated that the color changes of the product will exhibit less deformation if the desired humidity level is obtained quickly during the drying process using the thin slice microwave drying method. However, this should just be viewed as a suggestion for minimizing color change. Numerous criteria, including color change, drying duration, nutrient content, and shelf life, should be assessed concurrently while determining the drying process.
Ana Ürün Olarak Yetiştirilen Bazı Yerfıstığı (Arachis hypogaea L.) Genotiplerinin Önemli Kalite Unsurlarının Belirlenmesi
Authors: KAYA Ali Rahmi , AYSABAR Zeliha
Published: November 2022

Bu araştırma, ana ürün olarak Kahramanmaraş ili şartlarında yetiştirilen 12 yerfıstığı (Arachis hypogaea L.) genotipinde önemli kalite unsurlarını tespit etmek amacıyla yapılmıştır. Çalışma Kahramanmaraş şartlarında 2016 yılında yürütülmüştür. Deneme, üç tekerrürlü ve tesadüf blokları deneme deseninde kurulmuştur. Denemede doymuş yağ asitlerinden olan, palmitik, stearik, araşidik, behenik, lignoserik asit, yine doymamış yağ asitlerinden ise; oleik, linoleik ve linolenik asit oranları incelenmiştir. Bunların yanında; yağ stabilite değeri olarak oleik / linoleik asit oranı ve iyodin değeri, doymamış yağ/doymuş yağ oranı ve verimi ve protein verimi gibi kalite unsurları da incelenmiştir. Çalışma sonucunda yerfıstığı genotiplerinde; oleik asit, linoleik asit, linolenik asit ve oleik / linoleik asit oranı, iyodin değeri ve doymamış/doymuş yağ oranı, yağ verimi ve protein verimi gibi önemli kalite unsurlarına ait değerleri sırasıyla, % 44.811-81.787, %3.955-36.066, % 1.109-1.465, % 1.242-20.677, % 77.197-101.012 ve % 4.684-7.674, 112.295-199.818 kg da-1 ve 56.311-105.204 kg da-1 arasında yer aldığı belirlenmiştir. Genotipler arasındaki farklılıklar ise incelenen bütün özellikler açısından çok önemli olduğu bulunmuştur. Kahramanmaraş şartlarında en yüksek yağ ve protein verimi eldesi için Osmaniye-2005 çeşidi önerilmektedir.
Dallı Darı (Panicum virgatum L.)’nın Silaj Olarak Değerlendirilme Potansiyeli
Authors: TUTAR Halit , KÖKTEN Kağan
Published: November 2022

Bu araştırma, Bingöl Üniversitesi Tarımsal Araştırma ve Uygulama Alanı’nda yetiştirilen 5 farklı dallı darı çeşidinin (Alamo, Cave in Rock, Cloud Nine, Kanlow ve Shawnee) silaj kalitesinin belirlenmesi amacıyla 2020 yılında yapılmıştır. Bitkiler çiçeklenme döneminden 10-15 gün sonra hasat edilmiş, parçalanan bitki örnekleri plastik bidonlara doldurulmuş ve oda sıcaklığında 45 gün süre ile fermantasyona bırakılmıştır. Silaj materyallerinde; fiziksel puan, kuru madde oranı, pH, asit deterjanda çözünmeyen lif (ADF), nötral deterjanda çözünmeyen lif (NDF), asit deterjan lignin (ADL), ham protein (HP), sindirilebilir kuru madde (SKM), kuru madde tüketimi (KMT) oranları, nispi yem değeri (NYD), asetik asit (AA), bütirik asit (BA), laktik asit (LA) ve propiyonik asit (PA) içerikleri incelenmiştir. Araştırma sonucuna göre; incelenen özelliklerin hepsinde dallı darı çeşitleri arasındaki farklılık istatistiki olarak p≤0.01 düzeyinde çok önemli bulunmuştur. Dallı darı çeşitlerine ait silajların fiziksel puanının 7-11 puan arasında, kuru madde oranının %40.21-47.21, pH değerinin 4.32-4.59, ADF oranının %40.72-49.67, NDF oranının %55.65-63.65, ADL oranının %12.50-15.07, HP oranının %4.82-8.42, SKM oranının %50.20-57.17, KMT oranının %1.90-2.17, NYD’nin 73.35-95.57, AA oranının %0.70-1.38, BA oranının %0.02-0.29, LA oranının %1.00-1.86 ve PA oranının %0.012-0.034 arasında olduğu tespit edilmiştir. Elde edilen verilere göre, dallı darı çeşitleri arasında en kaliteli silajın Cloud Nine çeşidinde olduğu tespit edilmiştir.
Günümüzün Sürdürülebilir Enerjisi Kentsel Katı Atıklar ve Türkiye Potansiyeli
Authors: EFE Şükran
Published: November 2022

Günümüzde enerji kadar önemli bir diğer problem de gelişen teknolojinin, artan nüfus ve yaşam standartlarının en önemli sonucu olan artan atık miktarıdır. Kentlerde oluşan atıklar, şehrin nüfus yoğunluğuna ve bölgenin tüketim alışkanlıklarına bağlı olarak değişmektedir. İçerisinde sıvı ve gaz atıkların bulunmadığı kentsel katı atıkları düzenli depolama alanları kullanarak hem bertaraf etmek hem de enerji elde etmek mümkündür. Çünkü katı atıklar biyolojik olarak bozunmakta ve bozunma sonucunda ortama %45-60 oranında metan, %40-60 oranında karbondioksit gazı salmaktadır. Depo gazı olarak da tanımlanan bu gazın potansiyeli, ülke nüfusunun ortalama 84 milyon, kişi başı atık miktarının ortalama 1,13 kg olduğu göz önüne alınırsa ne kadar yüksek olduğu aşikardır. Bu nedenle tüketimin ana sebebi olan insanoğlu doğada var olduğu sürece, kentsel katı atıklar sürdürülebilir bir enerji kaynağıdır. Bu çalışmada; 2020 yılı TUİK verileri kullanılarak her geçen gün artan düzenli katı atık depolama alanlarımızdan elde edilebilecek depo gazının güncel enerji potansiyeli araştırılmış ve diğer enerji kaynakları ile karşılaştırılması yapılmıştır.
Tellurium-containing Thiol-peroxidase-like Antioxidants and their Catalytic
Mechanism
Authors: Capperucci Antonella , Tanini Damiano
Published: November 2022

The development of novel small molecules with effective catalytic antioxidant properties is
highly sought after. A wide array of structurally diverse selenium- and tellurium-containing glutathione
peroxidase mimics have been studied over the past two decades. Within this arena, organotellurium
compounds generally exhibit higher catalytic properties with respect to selenium-containing analogues.
Different mechanisms accounting for the thiol-peroxidase-like activity of various classes of
organotellurium derivatives have been proposed. This review documents developments in this area
and provides an overview of the catalytic mechanisms proposed for the various classes of telluriumcontaining
thiol-peroxidase-like-catalysts.
The Aston Forensic Linguistic Databank (FoLD)
Authors: Petyko Marton , Busso Lucia , Grant Tim , Atkins Sarah
Published: November 2022

The Aston Forensic Linguistic Databank (FoLD) is a permanent,controlled access online repository for forensic linguistic data. We broadlyunderstand forensic linguistics as any academic research with a potential toimprove the delivery of justice through the analysis of language. FoLD thuscomprises a wide range of datasets with relevance to forensic linguistics andlanguage and law, including commercial extortion letters, investigative interviewsin police and other contexts, legal documents, forum posts from far-right onlinegroups, and comment threads from political blogs. This paper outlines how FoLDworks and its potential impact on the general discipline of forensic linguistics.
Peningkatan Kesadaran Internet Sehat Menggunakan Blog Berbasis Internet of Things bagi Pemuda Desa Miru-Kabupaten Lamongan
Authors: Suharto Miko Aditiya , Apriyani Maria Novita , Safitri Eristya Maya
Published: November 2022

Pandemi Covid-19 menyebabkan pergeseran aktifitas  manusia ke arah digitalisasi. UU ITE digunakan sebagai kontrol untuk memberikan kewajiban dan memberikan hak dari tiap-tiap Individu yang menggunakan Internet di Indonesia. Masyarakat Indonesia sebagai pengguna Internet yang awam terkadang belum paham betul aturan-aturan yang telah diatur pada UU ITE ini sehingga pada saat menggunakan Internet secara tidak sengaja Masyarakat tersebut melakukan pelanggaran-pelanggaran atau bahkan beberapa oknum sengaja menggunakan teknologi Internet ini secara melawan hukum. Tujuan pengabdian ini yaitu untuk meningkatkan kesadaran dan edukasi terhadap remaja-remaja Indonesia yang merupakan agen perubahan tentang penggunaan internet dengan baik dan benar khususnya di Desa Miru Kabupaten Lamongan. Pengabdian ini bertujuan agar nantinya para remaja ini dapat menggunakan internet dengan aman dan tidak ada indikasi melawan hukum. Metode yang digunakan dalam pengabdian ini yaitu sosialisasi dan pendampingan pembuatan blog. Edukasi penggunaan internet yang sehat dan aman dapat dilakukan dengan memanfaatkan blog berbasis Internet of Things. Blog ini nantinya akan menjadi media dalam penyebaran informasi internet sehat dan informasi lainnya seputar hukum siber di Indonesia sehingga para pengunjung dari blog tersebut dapat teredukasi dan wawasan mengenai cara penggunaan internet yang baik dan tidak melawan hukum bertambah.
 
Increasing Awareness of Healthy Internet Using Internet of Things-Based Blog for Youth in Miru Village-Lamongan Regency
The Covid-19 pandemic has caused a shift in human activity towards digitalization. The ITE Law is used as a control to provide obligations and give rights to each individual who uses the Internet in Indonesia. Indonesian people as ordinary Internet users sometimes do not understand the rules that have been regulated in the ITE Law so when they use the Internet they accidentally commit violations or even some people intentionally use this Internet technology against the law. The purpose of this service is to increase awareness and education of Indonesian teenagers who are agents of change about using the internet properly and correctly, especially in Miru Village, Lamongan Regency. This service is intended so that later these teenagers can use the internet safely and there is no indication that they are against the law. The method used in this service is socialization and mentoring for blog creation. Education on healthy and safe internet usage can be done by utilizing Internet of Things-based blogs. This blog will later become a medium for disseminating healthy internet information and other information about cyber law in Indonesia so that visitors from the blog can be educated and gain insight into how to use the internet properly and not against the law.
Evidence-based social cohesion interventions in local government
Authors: van der Waldt Gerrit , Fourie David J.
Published: November 2022

Promoting social cohesion is particularly critical in South Africa given the context of widening inequality, growing unemployment, and persistent racial inequalities. Without measurement, potential key contributing factors that may influence social cohesion (inequality, poverty, violence, gender conflicts, mistrust, etc.) will remain elusive, thereby complicating the formulation of effective policies and programmes in the local sphere of government towards improved social cohesion and inclusive development (Palmary, 2015; Rocha, Kunc, & Audretsch, 2020). Following a mixed method design, inclusive of a literature review, desktop survey, case study analyses and semi-structured interviews with three cohorts (n = 32), the purpose of this article was to outline the framework dimensions of an evidence-based measurement instrument (i.e., Municipal Social Cohesion Barometer) to gauge the extent to which municipalities succeed in promoting social cohesion. The findings revealed dimensions and indicators for such an instrument and concluded that without a measurement instrument, potential key determinants that influence social cohesion in local communities remain largely hidden, making it difficult to design initiatives aimed at enhancing social cohesion through a more inclusive approach to local development. The relevance of the findings is centred on the utilisation of an instrument for measuring social cohesion that enables policymakers to target key domains that currently limit national unity.
Radial Distribution of Solids Concentration in Downer
Authors: Yiping Fan , Zhao Yafei , Lu Chunxi
Published: November 2022

Two different radial solids concentration distributions in downer have
been reported, i.e. the ˄ shape combining with reverse-core-annulus and
the core-annulus structures. The occurrence of these two patterns has
not been quantitatively interpreted. In this paper, the aerodynamic
theory is used in two-phase flow analysis. A transverse force on the
particles, i.e. the Kutta-Joukowski transverse force, is introduced to
explain and quantify the formations of these two radial solids
concentration distributions in downer. This force is the function of the
particle velocity gradient, the slip velocity and the gas density. Based
on the available experimental data proposed in the published
literatures, the distribution of the Kutta-Joukowski transverse force in
downer is discussed. The results show that this force is the main factor
for these two profiles occurrence.
Anti-War Actionism (Art-Actionism): Features, Forms, and Evaluation of Possibilities
Authors: Khoma Natalia
Published: November 2022

In the article, the author elucidates the features of the postmodern approach to asserting the value of peace using the techniques of actionism (performance, happening, art installation, flash mob, etc.). Anti-war actionism is considered as an element of the system of sociopolitical actionism. A set of spectacular forms of non-violent public protest against armed aggression and its consequences are analyzed. The fact that today’s anti-war actionism has gone beyond the narrow artistic environment and entered the broad social dimension is proved. The empirical basis for the conceptualization of anti-war actionism includes two groups of actions: (1) anti-war actions carried out since the 1960s in the United States and Western Europe; 2) anti-war actions carried out in various countries in response to the Russian invasion of Ukraine in 2022. The author argues that anti-war actionism corresponds to its nature and purpose only if those who initiate and conduct actions are participant types of political culture. In other cases, only external form will be borrowed from actionism, but not content (pseudo-actionism). The symbolic language of anti-war actionism, which is based on objects, images related to the nature of war and its consequences, is investigated. The structure of anti-war actionism is determined: 1) professional actions of representatives of the artistic environment, which are elaborated in terms of artistic characteristics; 2) actions of public activists who use avant-garde artistic tools at the amateur level to organize and hold actions. The advantages and disadvantages of anti-war actionism as a technology of peace building are identified. The functions of anti-war actionism are determined.
Are You Scared of Humanity Re-engineering? Review of : Frischmann, B., Selinger, E. (2018). Re-engineering Humanity. Cambridge, United Kingdom; New York, NY: Cambridge University Press. 235p.
Authors: Somko Pavlo , Danko Anastasia
Published: November 2022

In the book “Re-engineering Humanity”, the authors show how strongly we should hold the development of technology and humanity in our hands. They convey all the responsibility we should be aware of, showing incredible examples of re-engineering humanity. This book will convince us why it’s so important we embed technologies with human values before they embed us with their own.
MANAJEMEN DINAS KEBUDAYAAN DAN PARIWISATA KOTA PEKANBARU DALAM MENGELOLA INFORMASI PASAR BAWAH SEBAGAI DESTINASI WISATA BELANJA TRADISIONAL
Authors: Almukarrom Iqbal Mahbub , Hartono Toni
Published: November 2022

Kota Pekanbaru sebagai ibu Kota dari Provinsi Riau merupakan salah satu Kota berkembang terutama dalam jasa serta perdagangan, ini merupakan salah satu alasan tingginya angka wisatawan yang berkunjung ke Kota Pekanbaru setiap tahunnya. Penelitian Menggunakan teori Manajeman Terry George R yaitu POAC, yaitu Planning (perencanaan), Organizing (pengorganisasian), Actuating (Pelaksanaan) dan Controling (Pengevaluasian). Berdasarkan hasil penelitian dan pembahasan, perencanaan yang disusun oleh Dinas Kebudayaan dan Pariwisata Kota Pekanbaru seperti pemanfaatan penyiaran informasi mengenai Pasar Bawah di media cetak, Penyelenggaraan agenda kepariwisataan dan lainnya.Kata Kunci : Manajeman, Pengelolaan, Objek Wisata Pasar Bawah Kota Pekanbaru.
PENERAPAN STANDAR AKUNTANSI KEUANGAN ENTITAS TANPA AKUNTABILITAS PUBLIK UNTUK MENJADI PENGUSAHA SUKSES
Authors: Sulistyowati Endah , Kusmaeni Emi , Setyawardani Lydia
Published: November 2022

Tujuan pendampingan ini memberikan pemahaman, semangat dan memanfaatkan peluang untuk berwirausaha. Faktor pendorong peningkatan perekonomian Indonesia adalah kewirausahaan melalui usaha mikro kecil menengah (UMKM) dapat meningkatkan kreativitas, kemampuan masyarakat dalam menyalurkan ide dan kreasi dengan memanfaatkan sumber daya alam yang tersedia. Hal tersebut dikarenakan Sekolah Tinggi Agama Islam Al Fithrah memiliki lokasi yang dekat dengan lingkungan Pondok Pesantren Assalafi. Memanfaatkan peluang usaha untuk memenuhi kebutuhan pendidikan para santriawan santriwati mulai dari Sekolah Dasar, Sekolah Menengah Pertama, Sekolah Menengah Atas, Perguruan Tinggi, dan memberikan solusi dalam bisnis yang dijalankan timbul permasalahan seperti kesulitan pembukuan usaha, cara menyusun laporan keuangan dianggap rumit dan kurang memperhatikan bisnis yang dijalankan dengan etika maka perlu metode yang digunakan untuk memberikan pelatihan adalah pengetahuan tentang etika bisnis, bimbingan pencatatan transaksi keuangan usaha dagang yang tertib teratur sampai penyusunan laporan keuangan sesuai penerapan Standar Akuntansi Keuangan Entitas Tanpa Akuntabilitas Publik (SAK ETAP).
Road to Polarisation. Analysis of Swiss Party Programmes 2015-2019
Authors: Jeřábek Martin , Hlaváčová Nicole
Published: November 2022

The polarisation in the Swiss party system increased in the last three decades. Party competition led individual parties to find instruments to strengthen party unity at the national level. Because of the unification at the national level it is important to study election party programmes. The main goal of the article was to investigate in what respect have these changes affected party election programmes. We compared contemporary programmatic positions of relevant political parties in the Swiss lower house which succeeded with more than 4 % of votes in the 2015 parliamentary elections. The findings of our detailed content analysis of the party programmes in predetermined categories (A-E) pointed to a growing level of polarisation on the right-left axis. We argued that the election programmes reflect the level of polarisation. We succeeded to set the parties on the right-left axis. There is no party we located in the exact centre of the spectrum according to their programme. The left part of the scale is more polarised than the right, the Green party (GPS) is located on the very end of the left part of the right-left axis, the Social democratic party (SP) and the Green liberals (GLP) are on the moderate left. FDP, BDP and CVP are according our study located on the right part of the spectrum. SVP was located almost on the very end of the right part of the spectrum. Our research concludes that the level of polarisation of current Swiss party system is high.
Results of the Total Hip Arthroplasty Using 3D Printing Technology
Authors: Kang Alamusi , Orgoi Sergelen , Sonomjamts Munkhbayarlakh , Dagvasumberel Gonchigsuren
Published: November 2022

Objectives: To study the value of 3D printing of custom THA femoral prostheses with conventional femoral prostheses in total hip arthroplasty for severe hip deformity. Methods: Total hip arthroplasty was used in the treatment of 107 severe hip joint deformity cases from June 2018 to June 2019. Fifty-six patients received conventional hip replacement stems and 51 patients received a custom 3D printed hip replacement stem designed to address their proximal deformity and leg length discrepancy. The operation time, intraoperative blood loss, postoperative weight-bearing time, Harris score before and after the operation, complications after surgery and the main angle measurement of compared to their contralateral hip were evaluated to determine the short-term efficacy of 3D printed total hip replacement femoral prosthesis compared to the common total hip replacement femoral prosthesis. Results: A total of 107 patients were followed up for an average of 12 months. The use of 3D printing technology in the preoperative design and custom prosthesis fabrication was associated with shortened operation time, less intraoperative blood loss, quicker time to postoperative full weight-bearing, and improved the Harris score in 1 year after the operation compared to conventional total hip replacement stem (p<.05). Our results revealed that there was a significant reduction in the femoral anteversion with a value of 13.06 ± 1.93 degrees (mean ± SD) in the custom prosthesis group compared to the conventional hip replacement group. However, there was no significant difference in neck-shaft angle, acetabular angle, and Sharp angle between both groups (p>.05). Conclusion: 3D printing technology created a virtual and realistic simulation, and personalized operation plan for patients with severe hip deformity, which was helpful for surgical treatment. The anatomical characteristics of patients with complex deformities were better addressed using the 3D printed femoral component and resulting in better patient outcomes and provided a new option for surgeons to manage these difficult cases.
Relationship between Uterine Cervical Cytopathology and Histopathology in Mongolia
Authors: Gotov Uyanga , Tsedenbal Batchimeg , Sharkhuu Enkhtuya , Dondov Oyunchimeg , Enkhbat Bayarmaa
Published: November 2022

Objectives: This study aimed to evaluate the correlation between uterine cervical squamous cell abnormalities by conventional cytology and corresponding histopathology, and to assess the accuracy between them. Methods: A total of 192 cytological smears of patients with squamous cell abnormalities who underwent colposcopy examination from April – December 2015 were included in this study. The final agreement between cytology and histopathology was defined by the evaluation of histology as a golden standard. Results: The agreement between cytology and histopathology evaluation was 65.6%, and the discrepancy was 33.6% (k=0.512). When the classes of cytology were evaluated for accuracy, it was discovered that NILM* had a higher sensitivity of 77.0%, a specificity of 87.0%, a false positive of 23% and a false negative of 13.0% (k=0.711). Among the LSIL cases a sensitivity was discovered of 39.0%, a specificity of 82.7%, a false positive of 61.0% and a false negative of 17.3% (k=0.392. However, in HSIL sensitivity dropped to 37.8%, specificity increased to 91.6%, false positive were 62.0% and false negative were 8.4% (k=0.501). Conclusion: The agreement for diagnosis of uterine cervical cytology and histopathology was 65.6% (n = 126) and the discrepancy was 33.6% (n = 64) (p = 0.001). The correlation between cervical cytology and histopathology remained moderate (kappa=0.512). Thus, it is proposed that an appropriate quality control system for the cytopathological confirmation may contribute to the further detection and treatment for uterine cervical cancer in Mongolia.
Basic & Clinical Pharmacology 14th Edition
Authors: Dorjsuren Narantungalag
Published: November 2022

No abstract  in English
Vitamin Regulation of Osteoclast Differentiation
Authors: Odkhuu Erdenezaya , Narmandakh Shijir , Zinamyadar Munkhjargal , Bold Juramt , Amgalanbaatar Avirmed , Sundui Enebish
Published: November 2022

Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This review focused on the positive or negative effect of vitamins on osteoclast differentiation in vivo and in vitro, especially signal transduction. Methods: A systematic review of the literature regarding the contributions of the osteoclast differentiation and vitamins was performed, and the most relevant findings on the effect of vitamins on osteoclast differentiation were selected. Results: Vitamin D, E, B1, B5, B6, and B12 have mainly anti-osteoporotic effects; however, their mechanism on osteoclast differentiation and activation are variable. Vitamins A and C have been considered to activate osteoclast differentiation and function, but some report a suppressive effect on osteoclast function. Vitamin K and B2 exert an inhibitory effect on osteoclast differentiation and activation both in vitro and in vivo. In contrast, a direct action of niacin, biotin, and folic acid on osteoclast differentiation and activation remains unclear. Conclusions: Collectively, vitamins act on osteoclast differentiation and function in various ways depending on cell type, cell maturation and microenvironment
Mycosis Fungoides: A Case Report
Authors: Nyamjav Bayartogtokh , Aleksai Nyamdari , Yadamsuren Enkhtur , Munkhbayar Ariunaa
Published: November 2022

Objectives: Mycosis fungoides (MF) is the most common group of cutaneous T-cell lymphomas. We reported this rare diagnosed case of MF in National Dermatology Center of Mongolia. Methods: Diagnosis was based on physical examination and laboratory testing. Bioethical permission for this research was given by the Biomedical Ethics Committee of Ministry of Health in Mongolia, May 23, 2017. Results: A 78-year-old woman presented for evaluation of a 7-year history of recurrent pruritic lesions that appeared as red patches and plaques on non-sun exposed areas. She was given the initial clinical diagnosis of psoriasis. Upon examination, the morphology, histopathology and immunohistochemistry indicated MF, IB stage. Conclusions: A reliable diagnosis of mycosis fungoides might be feasible only in conjunction with clinical, histopathological, and molecular criteria.
Burden of Chronic Hepatitis D in Mongolia
Authors: Gidaagaya Sarantuya , Namdag Bira , Batmunkh Munkhbat
Published: November 2022

No abstract in English
Position and Stability of the Prosthesis in Severely Deformed DDH Artificial Total Hip Replacement
Authors: Kang Alamusi , Liang-jia Ding , Bin Liu , Orgoi Sergelen , Dagvasumberel Gonchigsuren
Published: November 2022

Objectives: To analyze the correlation of prosthesis position selection during total hip replacement with clinical short and middle-term effects of Crowe III and Crowe IV hip dislocation. Methods: Clinical data of 28 cases of dysplasia and dislocation of the hip joint combined with severe osteoarthritis were retrospectively analyzed. During 2-year follow-up, patients were rechecked by imaging regularly to analyze the imaging changes of acetabulum prosthesis position and bone graft fusion. Harris hip score was used to assess the recovery of hip function. The correlation of prosthesis position and short and middle-term effects was analyzed. Results: The filling rate of medullary cavity of prosthesis was above 75%. The initial position was fixed and stable. The stability rate of femur-prosthesis interface reached 100%. Compared with pre-replacement, hip function was significantly improved at 6 months post surgery (p < 0.05). Conclusion: These results indicate that total hip replacement for Crowe III and Crowe IV hip dislocation can effectively reconstruct the acetabulum, recover hip function, and stabilize prosthesis. Total hip replacement is characterized by good filling rate, high stability of femoral prosthesis interface, and stable initial fixation. The clinical repair effect is strongly associated with the position of the prosthesis.
Indirect Impact of the COVID-19 Pandemic on Child and Adolescent Health and Possible Interventions for Low- and Middle-Income Countries
Authors: Mandakh Undram
Published: November 2022

No abstract in English
Evaluating Features of Congenital Primary Hypothyroidism and Its Outcomes in Mongolia
Authors: Tsevgee Altantuya , Munkhchuluun Tsolmon , Khurelbaatar Naranchimeg , Zagd Gerelmaa , Ganbaatar Erdenetuya
Published: November 2022

Objectives: Our goal was to assess the outcomes of congenital primary hypothyroidism and evaluate forms of dysgenesis forms among children diagnosed with congenital primary hypothyroidism Methods: A cross-sectional study recruited all children diagnosed with congenital primary hypothyroidism between 2013 and 2020. All data, including demographic, clinical examination report, laboratory test results, and results of hand x-ray and ultrasound of thyroid glands, was collected from parents and medical records at hospitals. Results: Thyroid dysgenesis accounted for 76.3% of the causes of congenital primary hypothyroidism. Of all participants, 43% had an intellectual disability, and their average delayed bone age was 12.74 months. The most common abnormality of the thyroid gland was hypoplasia (76.3%). The age at diagnosis was the significant predictor for skeletal maturity delay (k = 0.25; 95% Cl = 0.17 - 0.33; p < 0.001) and for intellectual disability (a OR = 1.04; p < 0.004). Conclusions: Dysgenesis of the thyroid gland was the main cause of congenital hypothyroidism. Age of diagnosis of congenital primary hypothyroidism was a significant determinant of irreversible adverse later outcomes among children in Mongolia.