bluuebunny/crossref_metadata_2025 huggingface dataset:
Diagnóstico de un caso de hepatotoxicidad por fármacos y suplementos herbales en un hospital de Pasto, Colombia
Authors: Ordoñez Zarama Yalila Andrea , Muñoz Delgado Edison Ramiro , Ruiz Ruiz Julio Alexander , Risueño Blanco José Alirio
Published: March 2023

El hígado es un órgano crucial en el metabolismo y algunas sustancias pueden inducir hepatitis toxica con alta morbimortalidad. La enfermedad hepática inducida por sustancias químicas y medicamentos es un desafío tanto diagnostico como terapéutico, puesto que requiere la realización de estudios de extensión para descartar otras entidades. A continuación se presenta el caso de una paciente femenina de 51 años sin comorbilidades de base, ingresada por clínica de 2 días de evolución consistente en ictericia progresiva, episodios diarreicos sin acolia ni otra manifestación adicional. Aparentemente, su cuadro fue provocado por la administración de nimesulida, 2 tabletas al día por 2 días, contra el dolor secundario a un quiste mandibular diagnosticado en días anteriores. Durante su ingreso a urgencias la paciente describió consumo crónico, a diario desde hace 4 años, de productos de Herbalife®. Cursa con elevación de transaminasas, prolongación del tiempo de protrombina (TP) e hiperbilirrubinemia directa. Se descartan enfermedades infecciosas e inmunológicas. Se decidió iniciar el cubrimiento antibiótico y vitamina K. Finalmente y por exclusión, se realizó una biopsia hepática que sugirió un proceso inflamatorio compatible con hepatitis inducida por fármacos. La mujer evolucionó favorablemente al suspender la medicación y el suplemento dietético referido. En conclusión, el caso expuesto constituye un punto inicial en el avance hacia la investigación en hepatotoxicidad por mecanismos compartidos de diversas sustancias simultáneamente, como lo sucedido a la paciente con el uso paralelo de Herbalife® y de nimesulida.
Bilioma espontáneo: reporte de un caso y revisión de la literatura
Authors: Cortés José S. , Polanía Galindo Santiago Adolfo , Polanía Liscano Héctor Adolfo
Published: March 2023

Los biliomas son colecciones de bilis fuera del árbol biliar. Las etiologías más frecuentes son la iatrogenia y el trauma. Los casos de biliomas espontáneos o atraumáticos son poco frecuentes. El manejo de los biliomas depende del tamaño y la localización y puede incluir vigilancia solamente, si el tamaño es < 4 cm, puede haber intervención percutánea o endoscópica. El uso de antibióticos depende del estado clínico del paciente. Presentamos el caso de un hombre que presentó un bilioma espontáneo 8 años después de una colecistectomía laparoscópica que, además de signos de coledocolitiasis, presentaba una estenosis del conducto biliar común. En los pacientes con clínica de patología biliar debe considerarse el diagnóstico de bilioma aun en los casos que no presenten antecedente de trauma o cirugía reciente con el fin de iniciar el tratamiento adecuado tempranamente. Muchos casos son asintomáticos y se resuelven espontáneamente, pero en ocasiones requieren manejo percutáneo o endoscópico.
Research in Basic Sciences: Results of some math and physics projects
Authors: Riascos Landázuri Henry , Lopez Vargas Juan David , Cortés Zapata Daniel , Gutiérrez Gutiérrez Alexander , García López Alberto
Published: March 2023

Desde nuestra Facultad se presentan trabajos resultados de investigación que le aportan ignificativamente a las aplicaciones de las ciencias básicas y que son el resultado del compromiso y la dedicación de nuestros docentes investigadores, quienes trabajan para abordar problemas complejos y generar soluciones innovadoras y sostenibles. En el primer capítulo se presenta un estudio de las propiedades en nuevos materiales, en este caso del crecimiento de películas delgadas de grafeno en sustrato de silicio utilizando el método de deposición por láser pulsado (DLP) donde se utilizaron 6 técnicas de caracterización (Espectroscopía Raman, IRTF, MEB, SED, MFA, MACA) y como conclusión se tiene que las muestras similares al grafeno presentan propiedades de hidrofobicidad y las muestras de carbono amorfo tienen propiedades hidrofílicas. En el segundo capítulo se presenta un modelamiento matemático y una discusión sobre la existencia de soluciones de segunda clase en una ecuación de Tricomi, se plantea la existencia de soluciones periódicas de una generalización de la ecuación de Tricomi, el estudio se realiza mediante métodos perturbativos; de igual forma, se usa la función de Melnikov para encontrar las condiciones bajo las cuales se conservan las curvas homoclínicas. En el tercer capítulo se plantea una metodología de enseñanza-aprendizaje para enseñar la geometría descriptiva básica y la resolución de problemas a través del software Autocad.
Maternal folic acid supplementation and the risk of ankyloglossia (tongue-tie) in infants; a systematic review
Authors: Rubin Gal , Stewart Catherine , McGowan Laura , Woodside Jayne , Barrett Geraldine , Godfrey Keith , Hall Jennifer
Published: March 2023

Background: Maternal folic acid supplementation is protective
against the development of neural tube defects (NTDs) in babies.
However, recent public-facing communications have raised concerns about
a causal relationship between folic acid supplementation, particularly
after the first trimester, and ankyloglossia (tongue-tie) in infants.
Non-evidence-based communications are potentially harmful because they
could adversely affect adherence to folic acid supplementation,
increasing NTD occurrence. Objectives: To review evidence on
the relationships between maternal folic acid supplementation during
preconception and/or pregnancy and the risk of ankyloglossia in infants.
Search Strategy: We searched online bibliographic databases for
studies investigating the effect of maternal folic acid supplementation
during preconception or pregnancy on the occurrence of ankyloglossia in
offspring. Selection Criteria: Observational, interventional
studies, and systematic reviews assessing the relationships between
folic acid and ankyloglossia. Data Collection and Analysis: The
database searches yielded 93 articles. After removing duplicates and
screening titles and abstracts, 26 remained. One article was judged
relevant for inclusion in analyses; a case-control study that directly
mentions the relationship between folic acid supplementation and
ankyloglossia Main Results: One case-control study reported
that regular intake of folic acid supplements was higher in women with
infants with ankyloglossia. However, this study has limitations
regarding design, selection bias, and confounding, calling the findings
into question. Conclusions: Insufficient evidence exists for a
relationship between folic acid supplementation and ankyloglossia.
Currently, the benefits of folic acid supplementation far outweigh the
risks. This must be clearly communicated to patients by their clinicians
during preconception and antenatal care.
EFFICIENCY ANALYSIS USING FLYWHEEL ENERGY STORAGE TECHNOLOGY FOR REGENERATIVE BRAKE SYSTEMS IN ELECTRIC VEHICLES
Authors: Kurtulmuş Zeyneb , Karakaya Abdulhakim
Published: March 2023

The increase in fossil fuel consumption used in conventional vehicles
has adversely affected the amount of carbon emissions in the atmosphere.
Due to this negativity, many problems such as global warming, noise
pollution and cost have emerged. In order to find solutions to these
problems, many studies have been carried out to increase the energy
storage capacity of Electric Vehicles (EV) since 1835. EVs produced as a
result of these studies work more efficiently than traditional tools.
However, the driving range problem and charging time are the biggest
disadvantages of these vehicles. These disadvantages are a major
obstacle for EVs to replace traditional tools. In this study, an
experimental study was conducted on flywheel-battery in-vehicle
topologies, which are recommended to be used to increase the range in EV
and hybrid electric vehicles. In the application, two flywheels with the
same rotor radius and different masses were used. Energy was produced
from the generator through these flywheels. This energy was employed to
charge the batteries. The stored energy and power amounts were
investigated depending on the variation of the moment of inertia of both
flywheels at the maximum and minimum levels. As a result of this
examination, it has been determined which of the flywheels with the same
rotor radius but different masses is more suitable for electric
vehicles.
Land-use intensity influences European tetrapod food-webs
Authors: Botella Christophe , Gaüzère Pierre , O'Connor Louise , Ohlmann Marc , Renaud Julien , Dou Yue , Graham Catherine , Verburg Peter , Maiorano Luigi , Thuiller Wilfried
Published: March 2023

Land use intensification favours particular trophic groups which can
induce architectural changes in food-webs. These changes can deeply
impact ecosystem functioning, stability and robustness to extinctions.
However, the imprint of land management intensity on food-web
architecture has rarely been characterised across large spatial extent
and various land uses. We investigated the influence of land management
intensity on six facets of food-web architecture for 67,051 European
tetrapod communities, and its dependency on land use and climate. We
found that intensification promoted lower proportions of both apex and
basal species, with more connected and less compartmentalized food-webs,
and unexpectedly, favoured longer trophic chains in cities and decreased
omnivory in mediterranean climates. By favouring mesopredators and
undermining basal tetrapods, intensification might lead to new forestry
and agricultural pest outbreaks. Our results support mesopredator
regulation and apex predator protection where possible, but urban and
mediterranean contexts might need alternative strategies.
The role of education in Aristotle’s Politics
Authors: Dimic Zoran
Published: March 2023

Aristotle analyzed the problem of education in the seventh and eighth books
of Politics. Most researchers interpret his thoughts on education as ?the
education of the youth?. Some authors try to convince us of the significance
of contemplation and the problem of the best possible way of life in
analyzing Aristotle?s education theory. We would like to regard the problem
of education in another frame. The role of education is exceptionally
significant, judging from the central theme of Politics - the political
practice of human beings. Therefore, the critical question we want to ask
here is - what is the reason for creating a polis? Only when we understand
Aristotle?s answer to this question will we know why education plays such an
essential role in a polis. Aristotle avoids definitively prescribing and
ordering what music children and citizens should listen to. He leaves open
the critical question about ?how children and citizens should be educated?.
Disagreeing on the proper way of education is the very essence of education.
No ready-made best way to be educated has to be applied in every case. The
best way is only the one that is the outcome of the particular dispute. Just
as citizens, while in power, have to think about those who are subordinate
because they replace each other, when thinking about the aim of education,
they have to think about each other. Outside of that process, there is no
ideal form of education, the application of which would improve the
political community.
The Foucault effect in the sociology of knowledge
Authors: Ristic Dusan , Marinkovic Dusan
Published: March 2023

This research proposes that Foucault?s concepts of power/knowledge and
genealogy constitute a significant turning point, not only in philosophical
and historical terms but also in the research framework of the sociology of
knowledge. The first level of Foucault?s contribution to the sociology of
knowledge is widely recognized through the concept of discourse and its
dimensions of materiality, power and knowledge. The second level is the
analytical grid of power/knowledge itself, which focuses on the relays
established between them. The third level, which we consider a crucial area
open to further interpretation, is the concept of the history of the
present. Although Foucault?s contribution has already been acknowledged in
contemporary sociological research of knowledge, our objective is to expand
on this recognition by highlighting the significance of genealogy?s
dimensions to existing approaches, namely the historical sociology of
knowledge and sociology of knowledge approach to discourse.
Influence of structural and constructional parameters of knitted fabrics on the thermal properties of men's socks
Authors: Tasic Predrag , Trajkovic Dusan , Gersak Jelka
Published: March 2023

The research is focused on determining the influence of structural and constructional parameters of rib knitted fabrics on the thermal properties of men's socks. Men's socks are made in three different pattern constructions of three types of basic yarns: bamboo, cotton and a cotton/polyester blend with the additional filament polyamide yarn and wrapped rubber wire for the so-called render socks. For all analyzed sock rib patterns, the most important structural parameters of the yarn and construction parameters of the knitted fabrics were determined. Thermal properties of socks such as the cool touch feeling property, thermal conductivity, heat retention coefficient and thermal resistance were determined by using Thermal Labo and Thermal Mannequin measuring devices. The structural and constructional parameters of knitted fabrics were shown to affect the investigated thermal properties of the socks, making them more or less insulating or heat conducting. Values of the warm-cold feeling parameter as well as thermal conductivity vary depending on the construction pattern, showing a decrease as the number of face loops is increased i.e. in the sequence R1:1> R3:1> R7:1. The ability to retain heat decreases in the opposite sequence R7:1 > R3:1 > R1:1. The highest values of heat retention were determined for R7:1 rib knitted socks by both methods. A regression equation has been established with thickness, loop length, mass per unit area and porosity as independent variables, and thermal resistance (determined by the Thermo Labo method) as the dependent variable. The loop length and mass per unit area were shown to contribute significantly to the model.
Relative anchorage loss under reciprocal anchorage in mandibular premolar extraction cases treated with clear aligners
Authors: Tang Zhenxing , Chen Weichang , Mei Li , Abdulghani Ehab A. , Zhao Zhihe , Li Yu
Published: March 2023

Objectives

To compare mandibular relative anchorage loss (RAL) under reciprocal anchorage between first and second premolar extraction cases in bimaxillary protrusion mild crowding cases treated using clear aligner therapy (CAT).

Materials and Methods

Adult patients who met the following criteria were included: treated using CAT with bilateral mandibular premolar extractions and space closure using intra-arch reciprocal anchorage. RAL was defined as the percent molar mesial movement relative to the sum of molar mesial plus canine distal movement. Movements of the mandibular central incisor (L1), canine (L3), and first molar (L6) were measured based on superimposition of the pre- and post-treatment dentition and jaw models.

Results

Among the 60 mandibular extraction quadrants, 38 had lower first premolar (L4) and 22 had lower second premolar (L5) extracted. L6 mesial movement was 2.01 ± 1.11 mm with RAL of 25% in the L4 extraction group vs 3.25 ± 1.19 mm with RAL of 40% in the L5 extraction group (P < .001). Tooth movement efficacy was 43% for L1 occlusogingival movement, 75% for L1 buccolingual inclination, 60% for L3 occlusogingival movement, and 53% for L3 mesiodistal angulation. L1 had unwanted extrusion and lingual crown torquing whereas L3 had unwanted extrusion and distal crown tipping, on which the power ridges or attachments had little preventive effect.

Conclusions

The average mandibular reciprocal RAL is 25% or 40% for extraction of L4 or L5, respectively, in CAT cases. A RAL-based treatment planning workflow is proposed for CAT extraction cases.
Nestin gene expression in stromal precursor cells from the human bone marrow
Authors: Dorofeeva Alena I. , Savvateeva Tat'jana  F. , Shipounova Irina N.
Published: March 2023

INTRODUCTION: The hierarchy of stromal progenitors from the bone marrow is poorly characterized; multipotent mesenchymal stromal cells and colony-forming units of fibroblasts are isolated in culture. Mesenchymal stem cells do not have a unique combination of surface antigens, making it difficult to obtain the pure population. The expression of the nestin gene is often used as a marker of these cells.
AIM: To evaluate the level of expression of the nestin gene in multipotent mesenchymal stromal cells and in colony-forming units of fibroblasts and to characterize the change in its expression during the transition from oligopotent progenitor cells to monopotent ones.
MATERIALS AND METHODS: Stromal progenitors were analyzed in bone marrow samples from 19 donors by standard methods. A total of 296 individual clones of fibroblast colony-forming units were obtained from the same bone marrow samples. The cells were analyzed for the ability to differentiate toward the adipogenic and osteogenic lineages. Relative expression level of nestin gene was analyzed in all cells.
RESULTS: Mean relative expression level of nestin did not differ significantly in multipotent mesenchymal stromal cells (0.410.13) and in the total population of colony-forming units of fibroblasts (0.240.05). In individual clones of colony-forming units of fibroblasts, nestin expression was not significantly higher than in the total population (0.310.04). When analyzing colony-forming units of fibroblasts differing in their differentiation potential, the highest expression of nestin was found in the group of monopotent osteogenic progenitors, while its expression was significantly lower in oligopotent progenitors.
CONCLUSION: Nestin gene expression in mesenchymal stromal progenitors from the bone marrow is not specific for mesenchymal stem cells and cannot be used as a unique marker of this cell type. According to our data, a high level of nestin expression rather identifies monopotent osteogenic progenitors.
La tutoría universitaria: una necesidad de desarrollo en los contextos de la educación virtualizada
Authors: De la Peña Consuegra Geilert , Arteaga Loor Genny del Carmen , Arcentales Chaw Paul Fernando , Obando Mendoza Lesbia María
Published: March 2023

En el presente artículo se expresan las principales consideraciones resultantes de un estudio centrado en la determinación de los criterios consecuentes y perceptivos de los estudiantes sobre el proceso de tutoría en el contexto universitario, desde la perspectiva del desempeño del docente en el desarrollo de entornos virtuales de enseñanza y aprendizaje (EVEA). En consecuencia, se profundiza en aspectos teóricos que garantizan revelar y ofrecer una serie de funciones, cualidades y habilidades a tener en cuenta por los docentes en su labor tutorial.Para la obtención y procesamiento de información, se consideró el empleo de instrumentos y técnicas, así como el estudio documental para las aportaciones teóricas y su sistematización. Se aplicaron encuestas, entrevistas y observaciones al seguimiento y control del desarrollo de cursos virtuales y el desempeño tutorial de los docentes.La muestra fue conformada por 300 estudiantes de dos universidades, donde ellos se encontraban realizando sus estudios desde la presencialidad y la semipresencialidad, con el empleo de la EVEA.Los resultados obtenidos, confirman que los estudiantes perciben mayor atención tutorial en torno al área académica, en el que se garantizan niveles de ayuda y orientación, como complemento a los contenidos y seguimiento de su aprendizaje, sin ser suficientemente dirigido hacia áreas como la personal y la profesional.En esta realidad educativa las funciones como tutor son determinantes para el éxito de la actividad formativa centrada en el estudiante. Se entrega una visión general de dicho proceso, las áreas de su accionar, cualidades y habilidades requeridas por el docente.
Revitalization of Istihsan Bi Al 'Urfi in Sharia Financing: Fatwa Study 2010-2018
Authors: Mukri Syarifah Gustiawati , Harisah Harisah , Shapiulayevna Aliyeva Patimat
Published: March 2023

The community's need for sharia financing transactions is very urgent. So that Islamic law products are required to be able to provide guidelines for community economic transactions as a form of response to community needs. From this, this study examines how the concept of istihsan bi al 'urfi was revitalized in one fatwa from 49 fatwas set by the DSN-MUI during the 2010-2018 period as evidence for legal determination. Therefore, istihsan bi al 'urfi is a form of ijtihad scholars in establishing law. The research method used is a qualitative research method with a literature approach, namely by observing the use of the determination method with istihsan bi al 'urfi. The results of the study stated that there were 13 times the use of istihsan bi al 'urfi in determining the permissibility of financing based on sharia as a legal consideration. Although previously it was equipped with arguments from the Qur'an and hadith as well as ijma' and qiyas. This shows that DSN-MUI ijtihad always develops according to the demands of the times to develop Islamic legal products in the field of Islamic finance and economics without losing the basic values of sharia.
EVOLUSI TUBUH GUNUNGAPI DAN IMPLIKASI STRUKTUR GEOLOGI DI GUNUNG PESAWARAN-BETUNG, LAMPUNG
Authors: Natalia Happy Christin , Denhi Anjar Dwi Asterina
Published: March 2023

Provinsi Lampung didominasi oleh produk vulkanik yang membentuk berbagai pola morfologi, baik itu morfologi dataran, perbukitan, hingga kaldera. Aktivitas vulkanik di Provinsi Lampung erat kaitannya dengan aktivitas tektonik yang berkembang sejak Miosen. Namun, belum ada penelitian terperinci terkait aktivitas vulkanisme tersebut. Tujuan penelitian ini adalah untuk menentukan evolusi tubuh gunungapi strato di Gunung Pesawaran dan Betung serta menentukan implikasi struktur yang mempengaruhi sebaran produk gunungapi. Penelitian ini menggabungkan data analisis morfologi areal dan linear berdasarkan Digital Elevation Model (DEM) untuk menentukan evolusi tubuh gunungapi. Data area dan linear daerah penelitian dianalisis menggunakan peta topografi, hillshade, data kemiringan lereng, dan kelurusan yang diolah menggunakan perangkat lunak ArcGIS 10.5. Berdasarkan analisis area dan analisis linear terdapat empat domain area dan dua pola kelurusan yang ditunjukkan oleh perbedaan tekstur, morfologi, and produk vulkanik. Daerah penelitian memiliki morfologi kaldera purba yang dikenal dengan Kaldera Gebang, bagian dari domain 1, di bagian timur daerah penelitian, dataran vulkanik di bagian utara dan merupakan bagian dari domain 2, dan tubuh gunungapi strato tipe C, yaitu Gunung Pesawaran (domain 3) dan Gunung Betung (domain 4) yang menempati bagian tengah daerah penelitian. Dua pola kelurusan menunjukkan arah baratlaut-tenggara dan baratdaya-timurlaut. Kedua pola kelurusan ini menunjukkan bahwa perkembangan patahan dan morfologi gunungapi daerah penelitian dipengaruhi oleh aktivitas tektonik dan vulkanisme sejak umur Miosen.
Analysis of the Impact of the Distributed Generation Facilities on Protection Systems and Voltage Mode: Review
Authors:   Saint Petersburg Mining University, Ustinov D.A. , Aysar A.R. ,   Saint Petersburg Mining University
Published: March 2023

In recent decades, in the process of restructuring energy systems, centralized energy sources are being replaced by decentralized ones. This led to the emergence of a new concept (power generation) in power supply systems, especially in distribution systems, known as «distributed generation». Distributed generation was introduced into the power systems, especially at the low voltage level, to make them more reliable, safer and efficient. At the same time, various problems appeared in the power supply systems that require solving issues of ensuring the selectivity and sensitivity of the protection action, maintaining the required voltage level. Since the current and future trends in the development of electric power systems are aimed at increasing the integration of distributed generation, especially through installations, made based on renewable energy sources, it is required to conduct studies on the impact of these generation technologies on the distribution networks. When using distributed generation, setting up the protection system is associated with the problems associated with changes in the magnitude and direction of emergency currents. Distributed generation installations affect the fault current in a certain way, while influencing the overcurrent protection systems in terms of their coordination. In this regard, the alternative protection systems and algorithms can be used, such as directional overcurrent relays. In addition, highly penetrating distributed generation devices such as photovoltaic installations can cause overvoltage in the distribution systems, which must be effectively prevented. Thus, the paper considers the problems caused by the distributed generation and related to protection systems and voltage regulation in the distribution networks. Solutions for mitigating the negative impact of distributed generation on the power supply systems are proposed and considered in detail.
Penyuluhan Pencegahan Stunting Sejak Dini Bersama Mahasiswa KKN-T Universitas Alma Ata Yogyakarta
Authors: Azizah Dewi
Published: March 2023

Stunting is one of the nutritional problems as well as a serious threat to children in Indonesia. Currently, the stunting rate in Indonesia is 37.2% or equivalent to 8 million children with suboptimal growth[3]. This is behind our need to hold a stunting counseling program, especially in pringgading hamlet, Guwosari district, Pajangan District, Bantul Regency. The form of counseling is in the form of providing information services by collaborating with local posyandu cadres to convey information to the community to invite the community to carry out public health movements. The hope is that the holding of stunting counseling activities in pringgading hamlet can increase public awareness regarding the importance of child growth and development so that increasingly noticed and increasing, so as to prevent stunting and reduce the percentage of stunting in Indonesia, especially in pringgading hamlet, Guwosari District, Pajangan District, Bantul Regency

Keywords: Student, Counseling, Stunting
Railway Arc Bridge Analysis Through Dynamic Tests
Authors: Braz Waldeli , Martins Cláudio , Ortigão Cristiana , Couto Antonio
Published: March 2023

This paper presents the dynamic monitoring carried out on a 458 m long railway Papagaios Bridge in Brazil. This is a concrete arch bridge built over 60 years ago, which needed repairs. The dynamic monitoring was designed to carry out a structural integrity assessment and to calibrate a numerical model to be used for the structural rehabilitation design. Vibration measurements were carried out on the bridge in selected locations. This paper addresses data analysis, the impact measurements when a train enters the bridge and modal analysis.
Dinamika Pelaksanaan Kebijakan Keamanan Pangan Lokal dalam Pencegahan Stunting
Authors: Ariyanti Rizka , Yusran Rahmadani , Alhadi Zikri , Malau Hasbullah
Published: March 2023

This study aims to explain the dynamics of local food safety policy strategies in Agam District in preventing stunting in Nagari Kamang Hilia. Nagari Kamang Hilia has extensive land for agricultural and plantation growth and has the potential to become alternative land for the development of local crops to support local food security policies, especially in preventing stunting. This study uses a qualitative method. Data was collected through interviews and documentation. The research informants were determined by purposive sampling. The research results prove that the implementation of the local security policy strategy is not implemented in accordance with the policy objectives. This is caused by factors namely the food crops that are conserved are not in accordance with local commodities in Nagari, studies on local food are not carried out in depth; budget constraints; lack of program oversight from the Regency Government or Nagari Government for areas experiencing land problems, lack of professional experts in the field of local food safety and lack of transparency on stunting data from the cadre posyandu to Nagari Kamang Hilia.
Teoretyczne koncepcje kształtowania międzynarodowej konkurencyjności gospodarki narodowej
Authors: Schab Jakub
Published: March 2023

W artykule omówiono teoretyczne podejście do kształtowania koncepcji międzynarodowej konkurencyjności gospodarki narodowej. Wśród analizowanych koncepcji znalazła się koncepcja zlokalizowanego konkurowania i konkurencyjności międzynarodowej, a także koncepcja strategicznej polityki handlowej. W tekście wskazano, że obecnie obie strategie są realizowane na świecie z. Nie można jednak jednoznacznie stwierdzić, która jest skuteczniejsza. Za najlepsze rozwiązanie dla poszczególnych gospodarek można przyjąć połączenie elementów obu podejść.
Franczyza jako źródło finansowania działalności
Authors: Rychel Dominika , Skorża Monika , Zimoląg Monika
Published: March 2023

Franczyza z roku na rok staje się coraz bardziej powszechną formą prowadzenia działalności i dostarczania produktów i usług. W wielu branżach taki sposób prowadzenia działalności staje się coraz bardziej popularny. Na przykład w branży gastronomicznej wiele przedsiębiorstw to marki należące do sieci franczyzowych, np. McDonald, czy KFC. W opracowaniu przedstawiono główne założenia tej formy dystrybucji, rodzaje franczyzy, jej zalety i wady, metody jej finansowania oraz liczby przedstawiające ilość marek franczyzowych w Polsce na przestrzeni lat.
A new species of Arenallianassa (Decapoda: Axiidea: Callianassidae) from hydrothermal vents with notes on its ecology and a redescription of Arenallianassa arenosa (Poore, 1975)
Authors: Schnabel Kareen E. , Rowden Ashley A. , Poore Gary C. B.
Published: March 2023

The hitherto monotypic genus Arenallianassa Poore, Dworschak, Robles, Mantelatto and Felder, 2019 is revised following the discovery of a new species, Arenallianassa katrinae sp. nov. from New Zealand and Tonga. The original description of the type species Arenallianassa arenosa (Poore, 1975) is augmented. The new species has been found in localised high abundance in the vicinity of shallow (111–181 m depth) hydrothermal vents at each end of the Kermadec–Tonga Volcanic Arc system. This brings the number of callianassoids in New Zealand to six.
AD822, AW199, AW200 and AW201 antibodies against the human Fas receptor (CD95) bind the surface of HEK293 cells as revealed by flow cytometry
Authors: Dawit Soyan , Schwitzguebel Valerie , Seddiki Wissem , Soulie Paola , Anagbogu Nneka , Bennani Kenza , Brun Elise , Butterworth Hannah , Carry Jennifer , Aubry-Lachainaye Jean-Pierre , Gameiro Cécile , Durual Stéphane , Jauslin Tania , Ruetsche Audrey , Roch Laura , Diep Meg-Mai-Ly , Fer Odyssee , Guertler Maxime , Gureu Catalina , Herren Margaux , Leyss Simon , Liborova Karolina , Maître Marie , Manghetti Livia , Mencier Lucie , Moudarres Lana , Najand Gaelle , Guilhen Cyril
Published: March 2023

The recombinant antibodies AD822, AW199, AW200 and AW201 bind HEK293 cells expressing the human Fas receptor protein as assessed by flow cytometry.
Evaluation of effects on hepatocellular carcinoma cell line of Cocos nucifera: In vitro study
Authors: Tasdan Zeynep , Avci Gülçin Alp , Avci Emre
Published: March 2023

Objective: Cancer is one of the most important diseases today. The use of chemical drugs, surgical operations, and transplants is very common in its treatment. In addition to these treatment methods, studies include the effects of natural and plant-derived substances. Various substances are used in these studies, which are called phytotherapy. The antioxidant activity and cytotoxic effects of Cocos nucifera on hepatocellular carcinoma HepG-2 and the mouse fibroblast L929 cell line were investigated in this study.

Methods: In this study, in vitro cytotoxic effects of C. nucifera at different concentrations (7.81-500 mg/ml) were investigated on the L929 Mouse Fibroblast cell line and HepG-2 Hepatocellular Carcinoma cell line. In addition to these studies, their antioxidant capacity was evaluated via spectrophotometric methods. In this work, different concentrations of C. nucifera were examined.

Results: According to the results, C. nucifera had a cytotoxic effect in HepG-2 and ensured the proliferative effect of cells in the L929 cell line. Among C. nucifera extracts according to total antioxidant capacity results, C. nucifera extract was found to be the richest in antioxidants with 2.79 mmol/L, while the material with the lowest antioxidant capacity was determined to be C. nucifera milk. DPPH free radical scavenging activity results show the opposite.

Conclusion: In line with the data we obtained, it is thought that C. nucifera can be used in liver cancer studies, and its antioxidant effect may play an important role in balancing against oxidative stress. Simultaneously, the data show that the exposure time and concentrations of the active substance are related to the cytotoxic effect. However, it may be considered that the use of C. nucifera water, extract, and milk in cancer patients may be supported by more comprehensive clinical studies.
Comparison of two different file systems on postoperative pain after root canal instrumentation: A randomized controlled trial
Authors: Shahnawaz Saad , Shahroz Nabiya , Zafar Muhammad Ahmed , Sajjad Shahroz , Pasha Mehwish , Hussain Arfa Sabir
Published: March 2023

Introduction: In this study post instrumentation pain is evaluated between rotary hyflex CM files and conventional k-files at different time intervals.

Methodology: fifty patients were equally assigned into two groups and instrumented using hyflex cm or conventional files. VAS for pain was noted before the start of a root canal and after the procedure at 12, 24, and 48 hours.

Results: There was no significant difference at 12, 24, and 48 hours with P values being 0.127, 0.867, and 0.846 respectively.

Conclusion: There is no significant difference in causing post-instrumentation pain between hyflex CM and conventional files at different time intervals. However, when accessing preop pain of the conventional file group, it had more pain mean score compared to hyflex group. According to this study, Conventional files may be able to slightly decrease the chances of post-instrumentation pain more than hyflex CM instrumentation.
Management of denture stomatitis: An overview
Authors: Navabi Nader , Shakibaei Parham , Hassani Alireza Ranjbar
Published: March 2023

Denture stomatitis is a common inflammation of the palatal mucosa beneath removable dentures. The objective of this article was to examine the systematic reviews and clinical trials pertaining to the treatment of denture stomatitis. For this research, electronic databases (PubMed, Embase, Scopus, and ISI Web of Science) were searched from January 2000 to June 2021 using specified MESH keywords. Irrelevant articles were eliminated in three steps based on their titles, abstracts, and body texts. In the final analysis, 47 papers were selected, which included 12 systematic reviews and 35 clinical trials. Herbal compounds and denture disinfection were the interventions most commonly indicated. We concluded that, possibly due to the complex nature of this lesion’s etiology, there is no present definitive therapy guideline for this prevalent lesion.
Blood biomarkers predicting adverse clinical outcomes in congenital heart disease patients, with consideration for pulmonary valve replacement
Authors: Kainlauri Milla Marika , Kosovski Irina-Bianca
Published: March 2023

Objective: This review aims to make a brief overview of blood biomarkers’ clinical decision limits, possibly aiding in outcome prediction in all-aged Tetralogy of Fallot patients. Potentially, these biomarkers could also assist in necessity and timing of pulmonary valve replacement.

Methods: Studies with all-aged patients with Tetralogy or Pentalogy of Fallot and blood biomarkers, BNP, NT-proBNP and hs-cTn, usage in clinical outcome prediction were included. Additionally, pulmonary valve replacement indications were considered. Other congenital heart diseases, biomarkers irrelevant to clinical outcome and associated pathologies or physiological status were the exclusion criteria. Keywords, Tetralogy and Pentalogy of Fallot, pulmonary valve replacement, blood biomarkers, yielded 69 suitable studies from Google Scholar, PubMed and Web-of-Science. 30 studies were selected.

Results: Blood biomarkers were increased in TOF patients in comparison to controls; the higher the values, the worse adverse outcomes. Blood biomarkers combined with other biomarkers, imagistic methods or parameters showed promising results in outcome prediction.

Conclusions: Blood biomarkers are validated as follow-up predictors in congenital heart disease paediatric patients. Further research is required to establish age-appropriate clinical decision limits. Pulmonary valve replacement timing remains controversial.
Oral cancer chemoprevention: A review
Authors: Sujir Nanditha , Priyanka G , Ahmed Junaid , Saha Anindita , Chhaparwal Yogesh , Shenoy Nandita
Published: March 2023

Oral cancer is increasing in prevalence and its treatment is associated with high degree of morbidity and mortality. Thus, prevention of oral cancer is of utmost importance. Chemoprevention is the use of natural, synthetic, or biologic compounds to halt, reverse, or prevent the initial phases of carcinogenesis or the progression of neoplastic cells to cancer. This modality has been extensively researched in the last two decades for the prevention of oral cancer with the emergence of new information. Retinoids were the first chemopreventive agents to be tested in clinical settings. Since then, a number of new agents such as COX2 inhibitors, EGFR inhibitors, p53 targeted agents, thiazolidinediones and several natural agents have shown promise in oral cancer prevention. Chemopreventive trials in oral cancer tend to be long term studies and are thus challenging. This review article looks into the clinical evidence for the application of chemopreventive agents in clinical settings and also highlights the recent trends in oral cancer chemopreventive trials.
Clinical characteristics and endoscopic findings in autoimmune gastritis – A retrospective study
Authors: Gabos Gabriella , Nădășan Valentin , Nădășan Iris , Petruț Mădălina , Bernatchi Ioana , Bălășescu Mădălin , Nicolau Carmen
Published: March 2023

Objectives: Autoimmune gastritis (AG) is a rare condition that increases the risk of developing stomach adenocarcinomas or carcinoid tumours. The objectives of the present research were to summarise the clinical traits of AG patients, together with gastroscopic and histopatho-logic findings, demographic data, and hematologic characteristics.

Patients and methods: A medical centre assessed 58 AG patients from January 2019 to December 2022.

Results: The majority of the patients were female (73.7%), and the mean age of the participants at the time of the diagnosis was 57.7 ± 12.1 years. We identified pernicious anaemia (54.4%), iron deficiency anaemia (21.1%), as well as autoimmune disorders (96.5%). Though 78.9% of patients reported having gastrointestinal symptoms, 69% presented exclusively upper gastrointestinal symptoms, 17% only had lower, and 14% had concurrent upper and lower gastrointestinal symptoms. All 58 AG patients were examined for associated gastric lesions, although abnormal injuries were detected in only 22 of them. One patient (1.8%) had adenocarcinoma, while five patients (8.8%) had type 1 neuroendocrine tumours (NET). In addition, hyperplastic polyps were found in 16 (28.1%) individuals.

Conclusions: Other autoimmune diseases were present with AG, which showed a female predominance. Clinicians should give AG more significant thought by allowing access to interdisciplinary teams.
Opuntia fragilis (Nutt.) Haw. (Cactaceae) in the Bulgarian flora
Authors: Zahariev Dimcho
Published: March 2023

Opuntia fragilis (Nutt.) Haw. (Cactaceae) is the smallest and most cold-hardy species of genus Opuntia in North America. In Bulgaria it is grown as an ornamental plant, but in 2019 a population of this species was discovered by other researchers in natural habitats in Lozenska Mt (Western Bulgaria) at 630–660 m a.s.l. on an area (extent of occurrence) of ca. 100 m2. In July 2020, we established a population of this species on the Black Sea coast near the town of Primorsko (Eastern Bulgaria) at 5 m a.s.l. on an area of ca. 300 m2. The distance between the two populations is 360 km in a straight line and their origins are independent of each other. The two localities of this species are so far the only ones described not only for the territory of Bulgaria, but also for Europe.

Data are given on the conditions characterizing each of the localities. The possible reasons for the appearance in natural habitats of this alien plant species for the Bulgarian flora are considered. The impacts and threats this species may have on biodiversity in natural habitats are indicated. Measures have been proposed to control the populations of the species.
Tourism in Varna Black sea area – current situation and prospects for development
Authors: Sabrieva Sevdzhan
Published: March 2023

Tourism is one of the fastest growing industries of the new millennium. Bulgaria is a destination with an extremely large variety of natural and anthropogenic tourism resources and a relatively well-developed tourism sector of the economy, which brings significant income to the country’s economy. Varna tourist region is one of the leaders in the development of tourism, both for sea vacations and specialized types of tourism. Despite the great potential of the country and the researched tourist areas in particular, there are a number of problems related to uneven tourist development, seasonality, deteriorated tourist infrastructure and the quality of the services offered. The purpose of this paper is to study the current state of tourism and the opportunities for its development in the region.
Tourism as a prerequisite for changing the national identity
Authors: Metodieva Tsvetelina
Published: March 2023

The report reveals the impact of tourism on changing national identity. The interaction between tourism and cultural identity as social phenomena is noted. Globalization as a prerequisite for cultural disorientation is examined. The concept of anthropotok, as a mass self-sustaining process of identity change, is examined.
Community Involvement in Place-Making: Present Map Methodology
Authors: Zaleckis Kestutis , Vitkuviene Jurga , Jankauskaite-Jureviciene Laura , Grazuleviciute-Vileniske Indre , Karvelyte-Balbieriene Vilma
Published: March 2023

The aim this research was to develop and test the mapping methodology, that would be applicable in the process of community involvement into place-making process and would focus on functioning and usage of public spaces. The methodology is referred to a Present Map methodology and is structured as a one-day mapping workshop involving drawing from memory, fieldwork, identifying the locations in the geographical map, structuring of the collected information and entering data into interactive online Present Map. The application of the methodology in Sanciai historic district has demonstrated that this methodology allows both collecting the material about the people’s experiences in public spaces of the locality necessary for research and planning, as well as connecting community with the place and empowering it by providing the working tools for exploration and understanding of the place and platform for expression in a form of interactive online Present Map.
IT reliability as a source of sustainability for organisations operating during the COVID-19 pandemic
Authors: Tworek Katarzyna
Published: March 2023

The article aims to show that reliable IT support was crucial for the survival and sustainability of organisations during the COVID-19 pandemic. The article considers the negative effect of the crisis caused by the COVID-19 pandemic on the organisational sustainability of an organisation (i.e., organisational performance through employee job performance). It explores the role of IT reliability in mitigating such a negative effect. To verify the hypotheses, the empirical studies were performed during the COVID-19 crisis with 1160 organisations operating in Poland, Italy and the USA. The data were analysed using multiple linear regression models with mediators and moderators. The results confirmed that due to the ability to limit the severity of a crisis-induced negative effect on employee job performance (influencing organisational performance), IT reliability could be considered a mitigator for the negative effect of the COVID-19 crisis on the sustainability of organisations. The results indicate that IT reliability should be fostered among organisations operating during the COVID-19 pandemic to maintain sustainability.
Exploring the critical success factors of a resilient supply chain
Authors: Azam Mehreen Kausar , Hasan Syed Mehmood , Qureshi Sheheryar Mohsin
Published: March 2023

This study aims to identify and analyse critical success factors (CSFs) for an organisation aiming for a resilient supply chain. The methodology followed is the systematic analysis of big databases, such as Emerald, Science Direct, and Taylor & Francis, by using a specific set of keywords for filtering. The systematic literature review leads the author to the exploration of several CSFs, followed by their prioritisation by using principal component analysis. The paper highlighted eleven vital CSFs: top management commitment, development of an effective SCM strategy, logistics synchronisation, use of modern technologies, robust information and communication technology, information sharing with SC members, collaborative partnership, improved forecasting, trust development in SC partners, collaborative partnership, strategic partnership, development of reliable suppliers, continuous improvement in the preparedness and response practices, capacity building and training and staff development. The CSFs highlighted in the paper relate to all small and medium-sized enterprises (SMEs). This paper identifies the CSFs for developing a resilient supply chain that is comprehensive and has the potential to address uncertain circumstances. This work is the first of its kind on CSF assessment and categorisation in resilient supply chains.