bluuebunny/crossref_metadata_2025 huggingface dataset:
p38 Molecular Targeting for Next-Generation Multiple Myeloma Therapy
Authors: Morales-Martínez Mario , Vega Mario I.
Published: January 2024

Resistance to therapy and disease progression are the main causes of mortality in most cancers. In particular, the development of resistance is an important limitation affecting the efficacy of therapeutic alternatives for cancer, including chemotherapy, radiotherapy, and immunotherapy. Signaling pathways are largely responsible for the mechanisms of resistance to cancer treatment and progression, and multiple myeloma is no exception. p38 mitogen-activated protein kinase (p38) is downstream of several signaling pathways specific to treatment resistance and progression. Therefore, in recent years, developing therapeutic alternatives directed at p38 has been of great interest, in order to reverse chemotherapy resistance and prevent progression. In this review, we discuss recent findings on the role of p38, including recent advances in our understanding of its expression and activity as well as its isoforms, and its possible clinical role based on the mechanisms of resistance and progression in multiple myeloma.
The Role of Capsule Endoscopy in the Diagnosis and Management of Small Bowel Tumors: A Narrative Review
Authors: Fantasia Stefano , Cortegoso Valdivia Pablo , Kayali Stefano , Koulaouzidis George , Pennazio Marco , Koulaouzidis Anastasios
Published: January 2024

Small bowel tumors (SBT) are relatively rare, but have had a steadily increasing incidence in the last few decades. Small bowel capsule endoscopy (SBCE) and device-assisted enteroscopy are the main endoscopic techniques for the study of the small bowel, the latter additionally providing sampling and therapeutic options, and hence acting complementary to SBCE in the diagnostic work-up. Although a single diagnostic modality is often insufficient in the setting of SBTs, SBCE is a fundamental tool to drive further management towards a definitive diagnosis. The aim of this paper is to provide a concise narrative review of the role of SBCE in the diagnosis and management of SBTs.
Beneficial Use of the Combination of Gemcitabine and Dacarbazine in Advanced Soft Tissue Sarcomas: Real-World Data
Authors: Gurruchaga Sotés Ibon , Gómez-Mateo M. Carmen , Ortega Izquierdo María Eugenia , Martínez-Trufero Javier
Published: January 2024

Background: The combination of gemcitabine and dacarbazine has exhibited efficacy in terms of progression-free survival (PFS) and overall survival (OS) for aSTSs, albeit without robust confirmation from larger clinical trials. Methods: We conducted a retrospective study in a single institution involving aSTS patients treated with gemcitabine and dacarbazine. Results: 95 patients were assessed, pointing to a benefit in PFS of 3.5 months and an OS of 14.2 months. Patients with translocated histotypes had better PFS, while those with platelet–lymphocyte ratios (PLRs) surpassing a specific threshold or lower albumin levels had poorer overall survival. Conclusions: This study validates previous findings from three phase I–II trials, affirming the utility of this treatment approach in routine clinical practice.
Genetic, Epigenetic and Transcriptome Alterations in Liposarcoma for Target Therapy Selection
Authors: Lesovaya Ekaterina A. , Fetisov Timur I. , Bokhyan Beniamin Yu. , Maksimova Varvara P. , Kulikov Evgeny P. , Belitsky Gennady A. , Kirsanov Kirill I. , Yakubovskaya Marianna G.
Published: January 2024

Liposarcoma (LPS) is one of the most common adult soft-tissue sarcomas (STS), characterized by a high diversity of histopathological features as well as to a lesser extent by a spectrum of molecular abnormalities. Current targeted therapies for STS do not include a wide range of drugs and surgical resection is the mainstay of treatment for localized disease in all subtypes, while many LPS patients initially present with or ultimately progress to advanced disease that is either unresectable, metastatic or both. The understanding of the molecular characteristics of liposarcoma subtypes is becoming an important option for the detection of new potential targets and development novel, biology-driven therapies for this disease. Innovative therapies have been introduced and they are currently part of preclinical and clinical studies. In this review, we provide an analysis of the molecular genetics of liposarcoma followed by a discussion of the specific epigenetic changes in these malignancies. Then, we summarize the peculiarities of the key signaling cascades involved in the pathogenesis of the disease and possible novel therapeutic approaches based on a better understanding of subtype-specific disease biology. Although heterogeneity in liposarcoma genetics and phenotype as well as the associated development of resistance to therapy make difficult the introduction of novel therapeutic targets into the clinic, recently a number of targeted therapy drugs were proposed for LPS treatment. The most promising results were shown for CDK4/6 and MDM2 inhibitors as well as for the multi-kinase inhibitors anlotinib and sunitinib.
Evaluation of Ceramic Properties of Bauxitic Materials from SE of Iberian Range
Authors: Martín Domingo , Miras Adolfo , Romero-Baena Antonio , Guerrero Isabel , Delgado Joaquín , Barba-Brioso Cinta , Campos Paloma , Aparicio Patricia
Published: January 2024

The use of aluminum-rich clays and bauxites as refractory materials is common. Upon firing, these materials form mullite crystals in the shape of needles embedded in a siliceous and vitreous matrix, with mullite being responsible for the refractory properties. In this study, bauxite samples for use in refractory applications have been characterized. Chemical analysis revealed that the alumina content varied between 34 and 40%, with silica values generally being high (around 40%), except for one sample (26%). Two samples were found to be the most suitable for use as “refractory clay” refractories. However, high silica or Fe oxide contents can affect mineralogical transformations at high temperatures. Mineralogical analysis confirmed the presence of several minerals in the bauxite materials, including kaolinite, halloysite, anatase, rutile, gibbsite and boehmite. Differential thermal analysis (DTA) showed the decomposition of gibbsite and its partial transformation to boehmite and alumina, and the dehydroxylation of kaolinite, with primary mullite crystallization observed at a high temperature. These findings provide valuable information for the selection and optimization of bauxite materials for refractory applications, considering their chemical composition and mineralogical characteristics.
Effect of Gut Microbiota-Directed Complementary Food Supplementation on Fecal and Plasma Biomarkers of Gut Health and Environmental Enteric Dysfunction in Slum-Dwelling Children with Moderate Acute Malnutrition
Authors: Mostafa Ishita , Sthity Rahvia Alam , Lamiya Umme Habiba , Tariqujjaman Md. , Mahfuz Mustafa , Hasan S. M. Tafsir , Ahmed Tahmeed
Published: January 2024

Dietary supplementation with a gut microbiota-directed complementary food (MDCF-2) significantly improved weight gain and repaired gut microbiota, as reported in a recent randomized controlled trial on Bangladeshi children with moderate acute malnutrition (MAM). Environmental enteric dysfunction (EED) is a small bowel disorder, and recent evidence shows that it is linked to growth failure in children. Therefore, we intended to investigate whether supplementation with MDCF-2 has any role in modifying gut health by changing the levels of biomarkers of EED and gut inflammation in children with MAM. We randomly assigned 124 children aged 12–18 months to one of two intervention diets, either MDCF-2 or ready-to-use supplementary food (RUSF). Approximately 50 g of the diet was administered in two feeding sessions daily for 12 weeks. Stool and plasma biomarkers were assessed to evaluate intestinal health. Results showed that the average change in citrulline concentration (µmol/L) significantly increased among children who consumed MDCF-2 compared to those who consumed RUSF (mean difference-in-differences: 123.10; 95% CI: 3.60, 242.61; p = 0.044). The research findings demonstrated that MDCF-2 might have a beneficial effect on improving the gastrointestinal health of malnourished children.
Haulout Patterns of Harbour Seal Colonies in the Norwegian Skagerrak, as Monitored through Time-Lapse Camera Surveys
Authors: van Meurs Elsa , Moland Even , Bjørge Arne , Freitas Carla
Published: January 2024

Harbour seals (Phoca vitulina) are part of the Norwegian coastal ecosystem and can be observed on skerries, islands, and sandbanks along the coastline, sometimes in close proximity to inhabited areas. In this study, we used time-lapse camera surveys to monitor the haulout patterns of harbour seals at two selected sites in the Norwegian Skagerrak, Lyngør and Østre Bolæren, over 12 and 4 months, respectively. The goal was to investigate how the number of seals hauling out on land varied seasonally and how it was influenced by environmental parameters (wind speed, air temperature, and water level), the time of the day, and anthropogenic disturbances. As expected, the number of seals hauled out increased with increasing air temperature and decreased with increasing wind speed and water level. Clear circadian patterns in the seal haulout behaviour were identified during autumn and winter when a significantly higher number of seals were observed on land at night. Moreover, haulout patterns showed significant seasonal variation, with a peak in haul outs being observed during the moulting season in August. Despite an expected high usage of land during the breeding season in early summer, the number of seals hauled out at the Lyngor study site was low during this period, especially during weekends and summer holidays, maybe due to increased disturbance from boats. This study provides valuable insights into the factors influencing the haulout behaviour of the species in the region and suggests possible effects of human disturbance on harbour seal behaviour in the area.
The Dancing Marsenia: The First Record of a Swimming Velutinid Mollusc
Authors: Fassio Giulia , Bas Johan
Published: January 2024

Among gastropods, the ability to swim has developed independently several times, mostly among Heterobranchia. Only a few species of Caenogastropoda are known to have swimming adults. Velutinidae Gray, 1840, is a family of caenogastropods with a fragile shell enclosed by the mantle. The adults of this family are benthic and ectoparasites of ascidians. Here, we present the first recorded instance of a swimming velutinid, Marsenia cf. gemma, filmed in New Caledonia. The swim propulsion method was based on the movement of the snail’s foot, which followed a ∞-shaped curve. This first report changes our perspective on the biology of this family, unexpectedly placing it within the restricted group of swimming caenogastropods.
Innovations in Chest Imaging: How Can Patients Benefit?
Authors: Booz Christian
Published: January 2024

This Special Issue of Diagnostics entitled “Leading Diagnosis on Chest Imaging” provides an overview of recent technical developments in chest imaging and their clinical relevance, with a special focus on dual-energy CT (DECT) imaging [...]
A Systematic Scoping Review on Research Focusing on Professionals’ Attitudes toward School Attendance Problems
Authors: Hamadi Selina Eckhoff , Furenes May Irene , Havik Trude
Published: January 2024

This systematic scoping review was conducted to determine the extent of existing research on professionals’ attitudes toward school attendance problems (SAPs), including school refusal (SR), truancy (TR), school withdrawal (SW), and school exclusion (SE), in basic education. Five databases (ERIC, Academic Search Ultimate, Scopus, PsycINFO, and Web of Science) were systematically searched for relevant literature. Forty-five studies met the inclusion criteria that were set prior to the search and were eligible for inclusion. The results of this systematic scoping review reveal that there has been a continuous increase in studies addressing professionals’ attitudes toward SAPs since 2000, with the greatest number of studies published after 2019 and in Europe. Most studies were descriptive, cross-sectional, and used a qualitative approach and the most common informants were school-based professionals (i.e., teachers, school administrators, and other school staff). The included studies used a variety of concepts referring to SAPs and types of SAPs, underlining the present challenges in terminology and definitions that characterize the research field. The results of this review contribute to identifying gaps in knowledge and offer guidelines for future research as a prerequisite to enhance the contemporary comprehension of SAPs in research and in practice.
Impacts of Electric Vehicles Charging in Low-Voltage Distribution Networks: A Case Study in Malta
Authors: Azzopardi Brian , Gabdullin Yesbol
Published: January 2024

A high penetration of electric vehicle (EV) charging in low voltage (LV) networks can challenge grid stability due to voltage variations and limited feeder capacity. This research paper examines the integration of electric vehicle (EV) charging in real-life residential low voltage (LV) networks in Malta. The study utilizes smart metering data and presents a methodology framework and tools to analyze the impacts of EV charging on grid stability. The likelihood of challenges in the LV network is assessed by conducting simulations and deriving cumulative distribution functions (CDFs). The study also evaluates the impact of EV charging on the occurrence of network challenges and identifies predominant issues through multi-feeder analyses. Additionally, a regression analysis tool is developed to predict the impacts based on feeder characteristics. The results show strong relationships between feeder characteristics and EV charging processes, offering valuable insights for network planning and operations. However, it should be noted that the current EV charging penetration in the Maltese grid is below 1% in any LV feeder, suggesting the absence of significant technological hurdles at present.
Switching Behavior in the Polish Energy Market—The Importance of Resistance to Change
Authors: Lipowska Ilona , Lipowski Marcin , Dudek Dariusz , Mącik Radosław
Published: January 2024

(1) Background: Consumer switching behavior was one of the expected outcomes of the ongoing competitive reform in the European electricity industry. The aim of this study is to analyze the factors that affect the intention of consumers to switch from their incumbent supplier, who has a strong market position. This article follows the trend of describing and analyzing the situation of incumbent energy suppliers after energy market liberalization. (2) Methods: The research goal was to verify seven research hypotheses regarding switching intentions on the Polish energy market. For this purpose, structural equation modeling analysis using AMOS 29 was conducted. The survey was carried out in 2020, before the SARS-CoV-2 pandemic in Poland, and the research sample consisted of 1216 adults (clients of the incumbent supplier). (3) Results: Special attention was given to customers’ resistance to change, as it was found to be a factor that can impact customers’ decisions to switch, both directly and indirectly. Resistance to change can affect the trust that customers have in their current supplier’s brand, their perception of the costs involved in switching, and their intention to switch. The research also highlighted the importance of brand trust and perceived ease of change in the customers’ decision-making process. (4) Conclusions: An important factor that reduces switching behavior is the customer’s resistance to change; brand trust is a valuable asset that also reduces switching intention.
Cunninghamia lanceolata (Lambert) Hooker: A Promising Candidate for Phytoremediation of Cd-Contaminated Soils
Authors: Dai Dachuan , Hu Hongling , Wen Jing , Chen Hong , Chen Gang , Cui Xinglei
Published: January 2024

Cadmium (Cd) is one of the most common toxic heavy metal elements in soil pollution, which can be continuously enriched in the food chain and eventually threaten human health. Phytoremediation, which is using plants to transfer heavy metal elements from soils, is a promising solution for the remediation of heavy metal-contaminated soils. In this study, we evaluated whether Cunninghamia lanceolata (Lambert) Hooker (Chinese fir), a widely planted timber tree worldwide, had the potential to remediate Cd-contaminated soils through 90 days pot of experiments with different Cd concentration soils (0, 5, 10, 20, 50, 100 mg kg−1). C. lanceolata did not show obvious toxic symptoms in Cd-contaminated soils, although Cd inhibited plant growth and decreased net photosynthetic rate slightly. The activities of antioxidant enzymes increased significantly under Cd stress, indicating that C. lanceolata had a strong self-regulation ability and can tolerate Cd stress. The Cd bioconcentration factor (Cd concentration in plant divided by Cd concentration in soil) of C. lanceolata were greater than 1 at all Cd concentrations, indicating that C. lanceolata had a strong ability to absorb Cd, although Cd was mainly accumulated in roots. Our results indicated that C. lanceolata had a strong tolerance and phytostabilization ability of Cd. Considering the wide distribution worldwide, large biomass, and rapid growth of C. lanceolata, it could be a promising candidate for phytoremediation of Cd-contaminated soils.
Comparison of Xylem Anatomy and Hydraulic Properties in Black Locust Trees at Two Growth Stages in Semiarid China
Authors: Ma Changkun , Zhang Xi , Yao Qian , Zhou Beibei , Wang Quanjiu , Shao Mingan
Published: January 2024

Tree species transitioning between different developmental phases requires homeostatic adjustments in order to maintain the integrity of the tree hydraulic system. Hence, adjustments related to hydraulic traits (e.g., xylem conduit diameter) are of key functional significance. However, critical information on the differences between different developmental stages is rare. Using sapwood samples from 36 black locust trees with different growth stages (actively growing and declining stages) and a soil water gradient along a hillslope, xylem conduits at stem apexes and breast height (1.3 m above ground) stems were measured. The results showed marked differences in vascular traits between actively growing and declining trees. In contrast to actively growing trees, declining trees exhibited a reduction in conduit diameters accompanied by increased frequency with a positively skewed distribution and a subsequent decline in cumulative theoretical hydraulic conductivity. Across all sampled trees, the hydraulically weighted mean conduit diameter tapered acropetally from breast height to the stem apex. The extent of conduit tapering in actively growing trees (0.244, 95% CI 0.201–0.287) aligned with predictions from the hydraulic optimality model. Conversely, trees in a declining status displayed significantly reduced conduit tapering (0.175, 95% CI 0.146–0.198), indicating an elevation in hydraulic resistance with increasing tree height. Variations in hydraulic properties predominantly resulted from differences in tree height rather than variations in stem diameter or soil water content. The correlation between conduit diameter and soil water content in both actively growing and declining trees stemmed indirectly from variations in tree height rather than presenting a direct response to drought stress.
Identifying the Biological Characteristics of Anthracnose Pathogens of Blueberries (Vaccinium corymbosum L.) in China
Authors: Feng Wei-Kun , Wang Chong-He , Ju Yun-Wei , Chen Zeng-Xin , Wu Xue , Fang Dong-Lu
Published: January 2024

Vaccinium corymbosum L., commonly known as blueberry, is a valuable small fruit tree in terms of its economic significance and is primarily found in China within the regions of Heilongjiang and Jilin provinces. Additionally, it thrives in the areas spanning the middle and lower reaches of the Yangtze River. Beyond their economic value, blueberries play a crucial role within forest ecosystems, serving as a significant energy source and source of nutrients. Their presence contributes significantly to fostering stability, enhancing biodiversity, and acting as an indicator of environmental quality within forest ecosystems. Since August 2022, an unknown leaf disease has been found on a large scale in blueberry fields in Nanjing, Jiangsu Province, China. The disease causes leaf curling, wilting, and even early defoliation, severely reducing the yield and production value of blueberries. The pathogenicity test confirmed the virulence of the isolates (NG5-1, NG5-2, NG5-3, NG5-4, N2-1, and N2-2) against V. corymbosum. The two pathogens were identified as Colletotrichum fructicola and C. aenigma by observing the morphological characteristics of the isolates and combined with multilocus phylogenetic analyses (ITS, CAL, ACT, TUB2, ApMat, and GAPDH). Blueberry anthracnose, caused by C. aenigma, is the first report of this disease in China. The biological characteristics of C. aenigma were investigated under different conditions, including temperature, pH, light conditions, culture medium, and carbon and nitrogen sources. The optimal temperature for growth was determined to be within the range of 25–30 °C; C. aenigma exhibits optimal growth at a pH of 7–8. Mycelial growth is favored under conditions of partial light, whereas complete darkness promotes spore production. It was found that PDA medium was the most favorable medium for C. aenigma mycelial growth, and MM medium was the best medium for spore production; the most suitable carbon sources for colony growth and spore production were sorbitol and glucose, respectively, and the most suitable nitrogen source was peptone. This study furnishes a theoretical foundation for a more scientifically informed approach to the prevention and control of anthracnose on V. corymbosum.
Growth, Morphological Alterations, and Enhanced Photosynthetic Performance Promote Tolerance of Distylium chinense to Alternate Drought–Flooding Stresses
Authors: Yue Lei , Yu Chengrui , Abdoussalami Andlia , Li Xiaoling , Lv Kun , Huang Guiyun , Hu Meixiang , Yang Zhengjian
Published: January 2024

Disentangling the underlying processes of plant adaptations to multiple abiotic stressors is crucial regarding promissory species for the restoration of riparian ecosystems prone to suffering extreme flood and drought events in the context of global climate change and human activities. Distylium chinense is a dominant evergreen shrub, distributed in the riparian areas of the Yangtze River in China. Here, one field study and five controlled experiments (Control, CK; single drought, D; single flooding, FF; from drought to recovery to full flooding, D-R-FF; from full flooding to recovery to drought, FF-R-D) were conducted. More hypertrophied lenticels, adventitious roots, and the increased stem-base hypertrophy of D. chinense were observed under the D-R-FF condition compared with FF and FF-R-D. Interestingly, the increase of the net photosynthetic rate (Pn) coincidentally occurred with the increase of heme degradation by heme oxygenase (r = 0.608, p = 0.003). Pn of D. chinense in D-R-FF was about twice as much as that in FF-R-D. The enhanced photosynthetic performance was functionally coupled with the adequate water supply to promote the tolerance of D. chinense to alternate drought–flooding condition compared with no any flooding condition. The accumulation of soluble sugar was highest under D, followed by FF-R-D, FF and D-R-FF, which showed that soluble sugar accumulation over the drought period could trigger the recovery growth of flooded plants in later flooding. These data provided the first insights into the tolerance mechanisms by a suite of morphological alterations and physiological adaptations, especially in the enhanced photosynthetic performance of D. chinense under alternating drought and flooding stresses. So, D. chinense could be considered as a prominent shrub species in the restoration practices of wetlands, riparian areas, and other flood-prone forests.
Sex-Dependent Lipid Profile Differences in Skin Mucus between Non-Parental and Parental Discus Fish (Symphysodon haraldi) Determined by Lipidomics
Authors: Zhao Shichen , Wen Bin , Liang Hua , Gao Jianzhong , Chen Zaizhong
Published: January 2024

Discus fish, Symphysodon spp., have a unique parental care strategy where the fry feed on their parents’ skin mucus after hatching. Here, lipidomics was employed to compare the skin mucus lipid profiles of male or female discus fish during parental and non-parental care. By multivariate statistical analysis, clear separations were found between parental and non-parental female and between parental and non-parental male discus. In the comparison between female discus in the parental and non-parental stages, a total of 107 differentially expressed lipids (DELs) were observed, of which 23 showed increased levels during parental care. For male discus, a total of 108 DELs were found, of which 46 displayed increased levels during parental care. The main DELs were phosphatidyl ethanolamine and phosphatidylinositol, mainly involved in arachidonic acid and sphingolipid metabolism pathways. Further, by comparing parental male and female discus, we found 47 DELs involved in the glycerophospholipid metabolism pathway. Diglyceride showed a higher concentration in the skin mucus of parental females, while phospholipids showed a higher level in that of parental males. Our results revealed changes in the skin mucus lipid profiles of discus fish during parental care, as well as sex-dependent differences between parental fish.
Simultaneous Analysis of Organic Acids, Glycerol and Phenolic Acids in Wines Using Gas Chromatography-Mass Spectrometry
Authors: Garcia-Viñola Violeta , Ruiz-de-Villa Candela , Gombau Jordi , Poblet Montse , Bordons Albert , Reguant Cristina , Rozès Nicolas
Published: January 2024

Fermented beverages, particularly wines, exhibit variable concentrations of organic and phenolic acids, posing challenges in their accurate determination. Traditionally, enzymatic methods or chromatographic analyses, mainly high-performance liquid chromatography (HPLC), have been employed to quantify these compounds individually in the grape must or wine. However, chromatographic analyses face limitations due to the high sugar content in the grape must. Meanwhile, phenolic acids, found in higher quantities in red wines than in white wines, are typically analyzed using HPLC. This study presents a novel method for the quantification of organic acids (OAs), glycerol, and phenolic acids in grape musts and wines. The approach involves liquid-liquid extraction with ethyl acetate, followed by sample derivatization and analysis using gas chromatography-mass spectrometry (GC-MS) in selected ion monitoring (SIM) detection mode. The results indicated successful detection and quantification of all analyzed compounds without the need for sample dilution. However, our results showed that the method of adding external standards was more suitable for quantifying wine compounds, owing to the matrix effect. Furthermore, this method is promising for quantifying other metabolites present in wines, depending on their extractability with ethyl acetate. Fermented beverages, particularly wines, exhibit variable concentrations of organic and phenolic acids, posing challenges in their accurate determination. Traditionally, enzymatic methods or chromatographic analyses, mainly high-performance liquid chromatography (HPLC), have been employed to quantify these compounds individually in the grape must or wine. The approach of this proposed method involves (i) methoximation of wine compounds in a basic medium, (ii) acidification with HCl, (iii) liquid-liquid extraction with ethyl acetate, and (iv) silyl derivatization to analyze samples with gas chromatography-mass spectrometry (GC-MS) in ion monitoring detection mode (SIM). The results indicated successful detection and quantification of all analyzed compounds without the need for sample dilution. However, our results showed that the method of adding external standards was more suitable for quantifying wine compounds, owing to the matrix effect. Furthermore, this method is promising for quantifying other metabolites present in wines, depending on their extractability with ethyl acetate. In other words, the proposed method may be suitable for profiling (targeted) or fingerprinting (untargeted) strategies to quantify wine metabolites or to classify wines according to the type of winemaking process, grape, or fermentation.
Development of Pectin Particles as a Colon-Targeted Marjoram Phenolic Compound Delivery System
Authors: Siles-Sánchez María de las Nieves , García-Ponsoda Paula , Fernandez-Jalao Irene , Jaime Laura , Santoyo Susana
Published: January 2024

Marjoram is a culinary herb that has been widely employed in folk medicine and presents a high content in phenolics. Thus, the aim of this project was to design formulations to encapsulate phenolic compounds from marjoram to allow their release in the colon. For this purpose, pectin was used as an encapsulating agent, applying two different encapsulation techniques (ionic gelation and spray-drying), followed by a CaCl2 bath. The ionic gelation technique showed a higher yield (77%) compared to spray-drying (31%), and the particles obtained were smaller (267 nm). However, the microparticles obtained by spray-drying presented a higher encapsulation efficiency (93%). Moreover, spray-dried microparticles protected a higher percentage of the encapsulated phenolics from the action of gastrointestinal pHs and enzymes. Hence, the results showed that spray-drying was a more appropriate technique than ionic gelation for the encapsulation of marjoram phenolics in order to protect them during the gastrointestinal step, facilitating their arrival in the colon. These microparticles would also be suitable for inclusion in food matrices for the development of phenolic colon delivery systems.
Differences in the Chromogenic Effect of Corn Starch and Potato Starch on Paprika Red Pigment and Structural Characterisation
Authors: Su Fan , Wu Yongqiang , Cao Yanping , Wang Shaojia
Published: January 2024

The present study aims to investigate the chromogenic effect and the interaction between starch-pigment complexes of corn starch (CS) and potato starch (PS) complexed with paprika red pigment. Compared to PS, CS showed 12.5 times higher adsorption capacity for paprika red pigment. Additionally, the a* value of CS-P (26.90 ± 0.23) was significantly higher than that of PS-P (22.45 ± 1.84), resulting in a corn starch-paprika red pigment complex (CS-P) with a more intense red colour. The addition of paprika red pigment significantly decreased the particle size and porosity of CS by 48.14 ± 5.29% and 17.01 ± 3.80%, respectively. Conversely, no significant impact on PS was observed. Additionally, the Fourier transform infrared (FT-IR) spectroscopy results revealed that the starch molecules and paprika red pigment were bound to each other through strong hydrogen bonds. X-diffraction (XRD) results indicated that the starch-paprika red pigment complexes have a V-shaped structure. Furthermore, the relative crystallinity of the complexes between starch and red pepper pigment showed an increasing trend, however, the relative crystallinity of CS increased significantly by 11.77 ± 0.99–49.21 ± 3.67%. Consequently, the CS-P colouring was good.
Implantation of In Situ Gelling Systems for the Delivery of Chemotherapeutic Agents
Authors: Bakhrushina Elena O. , Mikhel Iosif B. , Buraya Liliya M. , Moiseev Egor D. , Zubareva Irina M. , Belyatskaya Anastasia V. , Evzikov Grigory Y. , Bondarenko Alexey P. , Krasnyuk Ivan I. , Krasnyuk Ivan I.
Published: January 2024

Implantation is a modern method of administering chemotherapeutic agents, with a highly targeted effect and better patient tolerance due to the low frequency of administration. Implants are capable of controlled release, which makes them a viable alternative to infusional chemotherapy, allowing patients to enjoy a better quality of life without the need for prolonged hospitalization. Compared to subcutaneous implantation, intratumoral implantation has a number of significant advantages in terms of targeting and side effects, but this area of chemotherapy is still poorly understood in terms of clinical trials. At the same time, there are more known developments of drugs in the form of implants and injections for intratumoral administration. The disadvantages of classical intratumoral implants are the need for surgical intervention to install the system and the increased risk of tumor rupture noted by some specialists. The new generation of implants are in situ implants—systems formed in the tumor due to a phase transition (sol–gel transition) under the influence of various stimuli. Among this systems some are highly selective for a certain type of malignant neoplasm. Such systems are injected and have all the advantages of intratumoral injections, but due to the phase transition occurring in situ, they form depot forms that allow the long-term release of chemotherapeutic agents.
Liquid Biopsy: A New Avenue for the Diagnosis of Kidney Disease: Diabetic Kidney Disease, Renal Cancer, and IgA Nephropathy
Authors: Dybiec Jill , Frąk Weronika , Kućmierz Joanna , Tokarek Julita , Wojtasińska Armanda , Młynarska Ewelina , Rysz Jacek , Franczyk Beata
Published: January 2024

Kidney diseases are some of the most common healthcare problems. As the population of elderly individuals with concurrent health conditions continues to rise, there will be a heightened occurrence of these diseases. Due to the renal condition being one of the longevity predictors, early diagnosis of kidney dysfunction plays a crucial role. Currently, prevalent diagnostic tools include laboratory tests and kidney tissue biopsies. New technologies, particularly liquid biopsy and new detection biomarkers, hold promise for diagnosing kidney disorders. The aim of this review is to present modern diagnostic methods for kidney diseases. The paper focuses on the advances in diagnosing three common renal disorders: diabetic kidney disease, renal cancer, and immunoglobulin A nephropathy. We highlight the significance of liquid biopsy and epigenetic changes, such as DNA methylation, microRNA, piRNAs, and lncRNAs expression, or single-cell transcriptome sequencing in the assessment of kidney diseases. This review underscores the importance of early diagnosis for the effective management of kidney diseases and investigates liquid biopsy as a promising approach.
Rumpelstiltskin, Kung Fu Panda, Jacques Derrida, and Conspiracy Theory: The Role and Function of Secrecy in Conspiracy Narrative and Practice
Authors: Bodner John
Published: January 2024

The article argues that where secrecy and secrets are key aspects of conspiracy theory narratives and practice, the genealogies of the/a secret have not been well understood. We argue that two forms of the secret, one a premodern notion of the secret as truth and revelation, the other a post-Derridean non-secret, inform two distinct forms and functions of contemporary conspiracy practice.
Adoption Processes of Innovations in Health Systems: The Example of Telemedicine in Germany
Authors: Rauner Yvonne , Stummer Harald
Published: January 2024

(1) Background: Individual adoption experiences represent important factors in implementing innovations. In the context of health systems, where the implementation of innovations aims to improve the quality of care, they provide an important basis for developing and adapting implementation strategies. (2) Methods: This study examines the adoption experiences of (tele-)medical experts (n = 13) using the example of telemedicine in the German healthcare system by means of a qualitative, guideline-based interview study. The interview guide, as well as the deductive–inductive analysis, is based on Rogers’ adoption theory. The transcription and analysis process was carried out according to Kuckartz. (3) Results: A total of 304 interview statements could be coded and assigned to the five main categories of persuasion, knowledge, implementation, decision and confirmation. More than half of all statements were coded under the main category persuasion, with its subcategories of convictions regarding the implementation of telemedicine (n = 89), international comparison of Germany’s development (n = 50), telemedicine as a way of optimizing resources (n = 22) and conviction to understand telemedicine as an overall system (n = 10). (4) Conclusions: This study provides insight into how the implementation of telemedicine in the German healthcare system is perceived by experts and allows for adjustments to the ongoing implementation strategy.
Biological Sex as a Moderator of Work Determinants of Health: Implications for Work and Stress
Authors: Hart Joy L. , Shuck Brad , Owen Jesse , Walker Kandi L. , Keith Rachel J.
Published: January 2024

This study examined whether biological sex moderates the relationship between experiences of workplace culture and urinary levels of catecholamines and their metabolites. We conducted a series of regression analyses (predictors: 3-methoxytyramine (3MT), 5-hydroxyindolacetic (5HIAA), and dopamine (DA); outcomes: employee engagement and workplace culture) in a sample of 218 participants. Compared to men, women rated workplace culture less positively (r = −0.210; p < 0.01) and had stronger positive associations with 3MT (r = 0.328; p < 0.001), DA (r = 0.376; p < 0.001), and 5HIAA (r = 0.168; p < 0.01). There was a significant moderation effect between 3MT and sex on employee engagement (b = −1.76 (SE = 0.84); p < 0.01), and 3MT had a positive significant association for men with engagement (p < 0.05); however, there was no significant association for women. Findings suggest that for women, less positive experiences with workplace culture could elevate 3MT, stimulating sympathetic nervous tone and potentially amplifying risks for negative health outcomes. Conversely, men who reported higher employee engagement had higher levels of 3MT, suggesting possible health risks associated with high levels of engagement, rather than lack of engagement. Overall, study findings suggested differential health risks based on biological sex, potentially impacting health risk policy development.
Comparison of the Life-Sustaining Treatment, Cardiopulmonary Resuscitation, and Palliative Care Implementation Rates between Homebound Patients with Malignant and Nonmalignant Disease Who Died in an Acute Hospital Setting: A Single-Center Retrospective Study
Authors: Miura Hisayuki , Goto Yuko
Published: January 2024

Objective: This study investigated and compared the implementation of life-support treatment (LST), cardiopulmonary resuscitation (CPR) implementation rates, and the influence of acute illnesses on the introduction of palliative care (PC) to homebound patients with malignant and nonmalignant disease, who subsequently died in an acute hospital setting. Methods: Among the homebound patients admitted to the ward in our hospital from 2011 to 2018, we investigated and compared the attributes, underlying diseases, causes of death, and rates of implementation of LST, CPR, and PC between patients with malignant and nonmalignant disease who died in the ward, using data obtained from hospitalization records. Furthermore, acute illnesses related to the introduction of PC were examined. Results: Of the 551 homebound patients admitted to the ward of an acute hospital, 119 died in the ward. Of the deceased patients, 60 had malignant disease and 59 had nonmalignant disease. Patients with nonmalignant disease had higher rates of LST implementation and CPR and a lower rate of PC. Patients with infectious disease, who required antimicrobial drugs, had significantly lower PC introduction rates. Conclusion: Understanding the influence of the timing of PC introduction in acute care for homebound patients with advanced chronic illness are issues to be considered.
Body Posture and Low Back Pain: Differences between Folk and Ballroom Dancers
Authors: Kochman Maciej , Cmela Gabriela , Kasperek Wojciech , Guzik Agnieszka , Drużbicki Mariusz
Published: January 2024

(1) Background: Dance is extremely diverse in its styles. Each of them presents different training, dynamics, and figures that may impact the body posture and the occurrence of low back pain. This observational study aimed to compare the sagittal curvatures and the range of motion (ROM) of the spine, as well as the low back pain occurrence and its intensity between folk and ballroom dancers. (2) Methods: Fifty-one participants took part in the study (nineteen folk dancers, fifteen ballroom dancers, and seventeen non-dancers) aged 18–32. Study groups did not differ in anthropometric parameters as well as in dancing experience and training frequency. Study procedures included a self-administered questionnaire and a physical examination of the sagittal spine curvatures and ROM. The questionnaire included questions about epidemiological data and the occurrence of chronic pain and its intensity using a Visual Analogue Scale (VAS). (3) Results: There was a significant difference in thoracic kyphosis angle between study groups (p = 0.02). The greatest angle was found in folk dancers and the lowest in ballroom dancers (40 vs. 33 respectively). We have found no significant differences in spine ROM, low back pain occurrence, and intensity between study groups (p > 0.05). We have found no correlation between low back pain and spine curvatures and ROM in dancers (p > 0.05), however, we found a very strong and negative correlation between thoracic spine range of motion and the pain intensity in non-dancers (R= −0.95, p = 0.003). The analysis also revealed that only in folk dancers, but not in ballroom dancers, the BMI correlates positively with dancing experience (R = 0.67, p = 0.002). (4) Conclusions: There are no differences in low back pain occurrence and pain intensity between folk and ballroom dancers, however, the prevalence of low back pain in dancers is very high. Folk dancers seem to have more flexed body posture compared to ballroom dancers.
Digital Care Program for Urinary Incontinence in Females: A Large-Scale, Prospective, Cohort Study
Authors: Janela Dora , Areias Anabela C. , Molinos Maria , Moulder Robert G. , Magalhães Ivo , Bento Virgílio , Cardeano Marta , Yanamadala Vijay , Correia Fernando Dias , Atherton Jennesa , Costa Fabíola
Published: January 2024

Female urinary incontinence (UI) is highly prevalent in the US (>60%). Pelvic floor muscle training (PFMT) represents first-line care for UI; however, access and adherence challenges urge new care delivery models. This prospective cohort study investigates the feasibility and safety of a remote digital care program (DCP) combining education and PFMT with real-time biofeedback with an average duration of 10 weeks. The primary outcome was the change in the Urinary Impact Questionnaire—short form (UIQ-7) from baseline to program-end, calculated through latent growth curve analysis (LGCA). Secondary outcomes included the impact of pelvic conditions (PFIQ-7), depression (PHQ-9), anxiety (GAD-7), productivity impairment (WPAI), intention to seek additional healthcare, engagement, and satisfaction. Of the 326 participants who started the program, 264 (81.0%) completed the intervention. Significant improvement on UIQ-7 (8.8, 95%CI 4.7; 12.9, p < 0.001) was observed, corresponding to a response rate of 57.3%, together with improvements in all other outcomes and high satisfaction (8.9/10, SD 1.8). This study shows the feasibility and safety of a completely remote DCP with biofeedback managed asynchronously by a physical therapist to reduce UI-related symptoms in a real-world setting. Together, these findings may advocate for the exploration of this care delivery option to escalate access to proper and timely UI care.
Knowledge and Visual Differentiation Ability of the Pressure Injury Classification System and Incontinence-Associated Dermatitis among Hospital Nurses: A Descriptive Study
Authors: Park Seungmi , Kim Eun Jung , Lee Son Ja , Kim Eun Jeong , Lee Ji Yeon , Hong Jung Eun
Published: January 2024

This study investigated clinical nurses’ knowledge and visual differentiation ability of the pressure injury classification system (PICS) and incontinence-associated dermatitis (IAD), additionally analyzing possible influencing factors. A convenience sample of 248 nurses took the PICS and IAD knowledge test (KT) and completed the visual differentiation ability test (VDAT), consisting of 21 photographs with clinical information. The overall mean score for correct answers was 12.65 ± 2.90 points in PICS and IAD KT and 11.43 ± 4.57 points in VDAT. Incorrect responses were most common for statements related to stage II, III, IAD for PICS and IAD KT, and deep tissue pressure injury (DTPI), unstageable, and stage III for VDAT. Significant correlations were found between PICS and IAD KT and VDAT (r = 0.252, p < 0.001). Factors affecting scores for VDAT were the scores of PICS and IAD KT, debridement experience in nursing patients with PI, and the management frequency of PI and IAD. Results indicate that nurses have an overall understanding of PICS and IAD, but low visual differentiation ability regarding stage III, DTPI, and unstageable PI. Continuing education is needed to further improve knowledge and visual differentiation ability for PICS and IAD.
Climate Change, Pressures, and Adaptation Capacities of Farmers: Empirical Evidence from Hungary
Authors: Lennert József , Kovács Katalin , Koós Bálint , Swain Nigel , Bálint Csaba , Hamza Eszter , Király Gábor , Rácz Katalin , Váradi Monika Mária , Kovács András Donát
Published: January 2024

This paper aims to analyze comprehensively the climate exposure, sensitivity, perception, adaptive capacity, vulnerability, and resilience of the Hungarian agricultural sector, particularly focusing on fruit, vegetable, and grape producers. Four distinct Hungarian case studies were examined, representing different regions with diverse environmental and socioeconomic conditions. The research combined quantitative and qualitative methods, including statistical and GIS analysis of climate, agricultural, and socioeconomic data, as well as field research and semi-structured interviews. The study investigated exposure, sensitivity, perception, and adaptation, leading to the identification of key components and influencing factors. Qualitative research revealed that farms operating in geographically close proximity, in the same regulatory and support environment, can have different adaptive capacities. In the current state of the adaptation process, the extent to which farmers can rely on supportive professional networks and seek out and adopt new practices is crucial. Field experience suggests that without a strong and supportive producer organization (extension network), farmers may prefer to resort to extensification (afforestation) to mitigate production risks. From a development policy perspective, it is worthwhile to present good practices and provide information on possible adaptation techniques through existing local sectoral organizations.