bluuebunny/crossref_metadata_2025 huggingface dataset:
Bringing fictional characters to life: reflections on co-creating a comic book with members of the public
Authors: Cairns Joanne Marie , Roberts Helen , Al-Khafaji Geraldine , Kwater Maria
Published: May 2023

There are growing calls for cancer screening to become more personalised by considering a range of risk factors, rather than a one-size-fits-all, age-based approach. The aim of this public involvement was to co-create a comic book about bowel cancer screening to be used as a visual elicitation tool in research focus groups with members of the public and healthcare professionals, as part of the At Risk study, to discuss their attitudes toward personalised bowel cancer screening, which would involve considering different risk factors. This article critically reflects on the co-creation process to develop the comic book, benefits and challenges, and some lessons learned to inform other researchers considering a similar approach. In total, ten public contributors (5 men and 5 women) from two public involvement networks participated in two successive online workshops to develop six fictional characters, two for each level of bowel cancer risk (low, moderate and high risk). This tool was then used in the At Risk study comprising five focus groups involving 23 participants, including members of the public (n = 12) and healthcare professionals (n = 11). The co-created comic book was a generally well-received research tool able to generate discussion about a complex topic, bowel cancer risk, in an accessible way. It was suggested that the comic book may also be extended beyond the research context to inform bowel cancer screening decisions and raise awareness of risk factors.
Management and outcome of intracranial chondroma of the dural origin: case report and review of the literature
Authors: Dokponou Yao Christian Hugues , El Kacemi Inas , Imoumby Fernand Nathan , El Akroud Sofia , Salami Mohcine , Elasri Abad Cherif , Gazzaz Miloud
Published: May 2023

Background

The intracranial chondroma is a sporadic type of benign tumor with an incidence of less than 0.5% of all intracranial tumors. Furthermore, this type of tumor has been reported more frequently at the skull base, less at the falx cerebri, and exceptionally of the dura, when it happened to be intracranial.

Case presentation

We report a challenging diagnosis and the successful management of a rare case of intracranial dural chondroma in a 19-year-old student without past medical history, revealed by secondary epilepsy with behavioral and mood disorder without neurological deficit.

Conclusion

The dural origin of intracranial chondroma is a rare type of tumor with nonspecific clinical manifestations, and diagnosis confirmation requires a histopathological finding. Surgical gross total resection of the lesion is the golden standard of its management.
Confidential computing and related technologies: a critical review
Authors: Sardar Muhammad Usama , Fetzer Christof
Published: May 2023

This research critically reviews the definition of confidential computing (CC) and the security comparison of CC with other related technologies by the Confidential Computing Consortium (CCC). We demonstrate that the definitions by CCC are ambiguous, incomplete and even conflicting. We also demonstrate that the security comparison of CC with other technologies is neither scientific nor fair. We highlight the issues in the definitions and comparisons and provide initial recommendations for fixing the issues. These recommendations are the first step towards more precise definitions and reliable comparisons in the future.
Association study between rs1571801 and rs16260 with prostate adenocarcinoma predisposition in Iranian population
Authors: Rahimi Abbas , Angaji Seyed Abdolhamid , Karimi Gilda , Beikzadeh Behnaz , Roudi Raheleh , Narouie Behzad
Published: May 2023

Background

Prostatic adenocarcinoma is the most frequent malignancy among elderly men after lung cancer, which has the second incidence and the fourth mortality rate in the Iranian population. The primary objective of this study was to investigate how single-nucleotide polymorphisms of the CDH1 gene (rs16260) and DAB2IP (rs1571801) are associated with the risk of prostate cancer through a multi-stage approach.

Results

In the first stage of the study (58 men), we compared the genotype frequency of polymorphisms rs16260 and rs1571801 in the case group to the control group to determine significant polymorphisms (P value < 0.4). No statistically significant difference was shown between the genotype frequency of rs1571801 in the case and control groups. Thus, rs1571801 polymorphism was eliminated at this stage, and only rs16260 polymorphism evaluated in the next stage. In the second stage, statistical analysis showed a significant difference between genotype frequency of rs16260 (P value = 0.037) in all participants. The effect of rs16260 on prostate cancer was not modified by age or PSA levels. Only the Gleason Score = 7 reveals a significant difference between the risk allele (A) and the allele (C) (rs16260).

Conclusions

According to the results of this study, rs16260 is associated with prostate cancer predisposition and might be used as a potential biomarker in prostate cancer. It should be noted that these results need to be confirmed in a larger population.
Use of the Behaviour Change Wheel to design an intervention to improve the provision of mental wellbeing support within the audiology setting
Authors: Bennett Rebecca J. , Bucks Romola S. , Saulsman Lisa , Pachana Nancy A. , Eikelboom Robert H. , Meyer Carly J.
Published: May 2023

Objective

This study describes the development of an intervention to increase the frequency of audiologists’ asking about and providing information regarding mental wellbeing within adult audiology services.

Design

The Behaviour Change Wheel (BCW), an eight-step systematic process, was followed to develop the intervention. Reports describing the first four steps are published elsewhere. This report describes the final four steps and details the intervention developed.

Results

A multifaceted intervention was developed to change audiologists’ behaviours relating to providing mental wellbeing support to adults with hearing loss. Specifically, three behaviours were targeted: (1) asking clients about their mental wellbeing, (2) providing general information on the mental wellbeing impacts of hearing loss, and (3) providing personalised information on managing the mental wellbeing impacts of hearing loss. A variety of intervention functions and behaviour change techniques were incorporated into the intervention, including instruction and demonstration, information about others approval, adding objects to the environment, use of prompts/cues, and endorsement from credible sources.

Conclusion

This study is the first to use the Behaviour Change Wheel to develop an intervention targeting mental wellbeing support behaviours in audiologists and confirms the usability and usefulness of the approach in a complex area of clinical care. The systematic development of the Ask, Inform, Manage, Encourage, Refer (AIMER) intervention will facilitate a thorough evaluation of its effectiveness in the next phase of this work.
Ketamine and psychotherapy for the treatment of psychiatric disorders: systematic review
Authors: Kew Bess M. , Porter Richard J. , Douglas Katie M. , Glue Paul , Mentzel Charlotte L. , Beaglehole Ben
Published: May 2023

Background

Ketamine is an effective short-term treatment for a range of psychiatric disorders. A key question is whether the addition of psychotherapy to ketamine treatment improves outcomes or delays relapse.

Aim

To identify all studies combining psychotherapy with ketamine for the treatment of psychiatric disorders to summarise their effects and make recommendations for future research.

Method

The review protocol was prospectively registered with PROSPERO (registration number CRD42022318120). Potential studies were searched for in MEDLINE, Embase, PsycINFO, SCOPUS, the Cochrane library and Google Scholar. Eligible studies combined ketamine and psychotherapy for the treatment of psychiatric disorders and did not use case reports or qualitative designs. Key findings relating to psychotherapy type, diagnosis, ketamine protocol, sequencing of psychotherapy and study design are reported. Risk of bias was assessed using modified Joanna Briggs critical appraisal tools.

Results

Nineteen studies evaluating 1006 patients were included in the systematic review. A variety of supportive individual and group, manualised and non-manualised psychotherapies were used. The majority of studies evaluated substance use disorders, post-traumatic stress disorder and treatment-resistant depression. Ketamine protocols and sequencing of ketamine/psychotherapy treatment varied substantially between studies. Outcomes were largely positive for the addition of psychotherapy to ketamine treatment.

Conclusion

The combination of psychotherapy and ketamine offers promise for the treatment of psychiatric disorders, but study heterogeneity prevents definitive recommendations for their integration. Larger randomised controlled trials using manualised psychotherapies and standardised ketamine protocols are recommended to clarify the extent to which the addition of psychotherapy to ketamine improves outcomes over ketamine treatment alone.
The histone H3/H4 chaperone CHAF1B prevents the mislocalization of CENP-A for chromosomal stability
Authors: Shrestha Roshan L. , Balachandra Vinutha , Kim Jee Hun , Rossi Austin , Vadlamani Pranathi , Sethi Subhash Chandra , Ozbun Laurent , Lin Shinjen , Cheng Ken Chin-Chien , Chari Raj , Karpova Tatiana S. , Pegoraro Gianluca , Foltz Daniel R. , Caplen Natasha J. , Basrai Munira A.
Published: May 2023

Restricting the localization of the evolutionarily conserved centromeric histone H3 variant CENP-A to centromeres prevents chromosomal instability (CIN). The mislocalization of CENP-A to non-centromeric regions contributes to CIN in yeasts, flies and human cells. Even though overexpression and mislocalization of CENP-A have been reported in cancers, the mechanisms responsible for its mislocalization remain poorly understood. Here, we used an imaging-based high-throughput RNAi screen to identify factors that prevent mislocalization of overexpressed YFP-tagged CENP-A (YFP–CENP-A) in HeLa cells. Among the top five candidates in the screen – the depletion of which showed increased nuclear YFP–CENP-A fluorescence – were the histone chaperones CHAF1B (or p60) and CHAF1A (or p150). Follow-up validation and characterization experiments showed that CHAF1B-depleted cells exhibited CENP-A mislocalization, CIN phenotypes and increased enrichment of CENP-A in chromatin fractions. The depletion of DAXX, a histone H3.3 chaperone, suppressed CENP-A mislocalization and CIN in CHAF1B-depleted cells. We propose that in CHAF1B-depleted cells, DAXX promotes mislocalization of the overexpressed CENP-A to non-centromeric regions, resulting in CIN. In summary, we identified regulators of CENP-A localization and defined a role for CHAF1B in preventing DAXX-dependent CENP-A mislocalization and CIN.
Prediction of Half-Life Time in Thermal Back Reaction of Photochromic Diarylbenzenes by Screening Approach
Authors: Hamatani Shota , Kitagawa Daichi , Nakahama Tatsumoto , Kobatake Seiya
Published: May 2023

Diarylbenzenes (DABs) have been developed as a novel family of T-type photochromic compounds. In this work, we endeavored to predict the half-life time (t1/2) in the thermal back reaction of DABs by a screening approach. By the combination of experimental and theoretical studies, we found a good relationship between the t1/2 and the activation energy estimated by theoretical calculations. Our results would provide useful information for the design of DABs having a desired thermal stability.
Clinical outcome after pencil beam scanning proton therapy and dysphagia/xerostomia NTCP calculations of proton and photon radiotherapy delivered to patients with cancer of the major salivary glands
Authors: Walser Marc Andrea , Bachmann Nicolas , Kluckert Jonas , Köthe A. , Tully Carson , Leiser Dominic , Lomax Antony John , Bizzocchi Nicola , Langendijk Johannes Albertus , Weber Damien C
Published: May 2023

Objectives

The purpose of this study is to report the oncological outcome, observed toxicities and normal tissue complication probability (NTCP) calculation for pencil beam scanning (PBS) PT delivered to salivary gland tumour (SGT) patients.

Methods

We retrospectively reviewed 26 SGT patients treated with PBSPT (median dose, 67.5 Gy(RBE)) between 2005 and 2020 at our institute. Toxicities were recorded according to CTCAEv.4.1. Overall survival (OS), local control (LC), locoregional control (LRC) and distant control (DC) were estimated. For all patients, a photon plan was re-calculated in order to assess the photon/proton NTCP.

Results

With a median follow-up time of 46 months (range, 3–118), 5 (19%), 2 (8%), 3 (12%) and 2 (8%) patients presented after PT with distant, local, locoregional failures and death, respectively. The estimated 4 year OS, LC, LCR and DC were 90%, 90%, 87 and 77%, respectively. Grade 3 late toxicity was observed in 2 (8%) patients. The estimated 4 year late high-grade (≥3) toxicity-free survival was 78.4%. The calculated mean difference of NTCP-values after PBSPT and VMAT plans for developing Grade 2 or 3 xerostomia were 3.8 and 2.9%, respectively. For Grade 2–3 dysphagia, the grade corresponding percentages were 8.6 and 1.9%. Not using an up-front model-based approach to select patients for PT, only 40% of our patients met the Dutch eligibility criteria.

Conclusion

Our data suggest excellent oncological outcome and low late toxicity rates for patients with SGT treated with PBSPT. NTCP calculation showed a substantial risk reduction for Grade 2 or 3 xerostomia and dysphagia in some SGT patients, while for others, no clear benefit was seen with protons, suggesting that comparative planning should be performed routinely for these patients.

Advances in knowledge

We have reported that the clinical outcome of SGT patients treated with PT and compared IMPT to VMAT for the treatment of salivary gland tumour and have observed that protons delivered significantly less dose to organs at risks and were associated with less NTCP for xerostomia and dysphagia. Noteworthy, not using an up-front model-based approach, only 40% of our patients met the Dutch eligibility criteria.
Translation regulation by a guanidine-II riboswitch is highly tunable in sensitivity, dynamic range, and apparent cooperativity
Authors: Focht Caroline M. , Hiller David A. , Grunseich Sabrina G. , Strobel Scott A.
Published: May 2023

Riboswitches function as important translational regulators in bacteria. Comprehensive mutational analysis of transcriptional riboswitches has been used to probe the energetic intricacies of interplay between the aptamer and expression platform, but translational riboswitches have been inaccessible to massively parallel techniques. The guanidine-II (gdm-II) riboswitch is an exclusively translational class. We have integrated RelE cleavage with next-generation sequencing to quantify ligand-dependent changes in translation initiation for all single and double mutations of thePseudomonas aeruginosagdm-II riboswitch, a total of more than 23,000 variants. This extensive mutational analysis is consistent with the prominent features of the bioinformatic consensus. These data indicate, unexpectedly, that direct sequestration of the Shine–Dalgarno sequence is dispensable for riboswitch function. Additionally, this comprehensive data set reveals important positions not identified in previous computational and crystallographic studies. Mutations in the variable linker region stabilize alternate conformations. The double mutant data reveal the functional importance of the previously modeled P0b helix formed by the 5′ and 3′ tails that serves as the basis for translational control. Additional mutations to GU wobble base pairs in both P1 and P2 reveal how the apparent cooperativity of the system involves an intricate network of communication between the two binding sites. This comprehensive examination of a translational riboswitch's expression platform illuminates how the riboswitch is precisely tuned and tunable with regard to ligand sensitivity, the amplitude of expression between ON and OFF states, and the cooperativity of ligand binding.
Aural Simulacra
Authors: Μεσσηνέζης Λουκάς
Published: May 2023

Η έννοια της υπερπραγματικότητας και το φαινόμενο της προπόρευσης των ομοιωμάτων έχει συζητηθεί στο παρελθόν από λόγιους του μεταμοντερνισμού. Κάτι τέτοιο ωστόσο δεν έχει πραγματοποιηθεί στον ίδιο βαθμό, όσον αφορά το πεδίο μελέτης της ακουστικής πραγματικότητας. Με την παρούσα έρευνα θελήσαμε να εξετάσουμε τα παραπάνω φαινόμενα στο πλαίσιο μελέτης των τεχνών του ήχου. Ως συνέπεια η συζήτηση μετατοπίστηκε στην έννοια της ηχητικής υπερπραγματικότητας και την αναγνώριση και ανάλυση των αντίστοιχων ακουστικών ομοιωμάτων. Με την υπόθεση εργασίας πως το ηχητικό σήμα μπορεί να αναγνωσθεί ως ένα σύστημα σημαίνοντος-σημαινομένου, πραγματοποιήσαμε μία αναγωγή των διαδοχικών τάξεων της εικόνας, όπως τις ορίζει ο J. Baudrillard, στις αντίστοιχες τάξεις του ακούγεσθαι. Με αυτό τον τρόπο αναδύθηκε η μυστηριακή τάξη, η τάξη του κακού, η τάξη της μαγείας και εκείνη των αμιγών ακουστικών προσομοιωμάτων. Η μυστηριακή τάξη αφορά ακουστικά ομοιώματα, τα οποία είναι ακριβή αντίγραφα κάποιας ριζικής ακουστικής πραγματικότητας. Τα ακουστικά ομοιώματα της τάξης του κακού διαστρεβλώνουν κάποια αφηρημένη ακουστική πραγματικότητα. Στην τάξη της μαγείας τα ομοιώματα αποκρύπτουν την απουσία κάποιας ακουστικής πραγματικότητας, ενώ τέλος τα αμιγή ακουστικά προσομοιώματα δεν έχουν σχέση με οποιαδήποτε ακουστική πραγματικότητα. Μέσα από τη φωνογραφία και την αμαλγάμωση πραγματικοτήτων, την ακουστική βιομιμητική και διάφορους αυτοποιητικούς τρόπους δημιουργίας, την ακουστικοποίηση πραγμάτων από το τίποτα και τη δημιουργική χρήση της επιστήμης της ηχητικής αρχαιολογίας, το παραγόμενο καλλιτεχνικό έργο ανέδειξε τα ιδιαίτερα χαρακτηριστικά της εκάστοτε τάξης ακουστικών ομοιωμάτων, τη σχέση τους με την ακουστική πραγματικότητα και τον καταλυτικό ρόλο των μέσων και της αντίληψης κατά την οντολογική μεταμόρφωση του ηχητικού σήματος.
Έλεγχος της αποτελεσματικότητας ενός προγράμματος για ενίσχυση του ευ ζην των εκπαιδευτικών υπό το πρίσμα της θετικής ψυχολογίας
Authors: Χαραλάμπους Βίκυ
Published: May 2023

Σκοπός της παρούσας διατριβής ήταν η δημιουργία, η υλοποίηση και ο έλεγχος της αποτελεσματικότητας ενός ψυχοεκπαιδευτικού προγράμματος υπό το πρίσμα της Θετικής Ψυχολογίας για την ενίσχυση του ευ ζην των εκπαιδευτικών. Για να επιτευχθεί ο σκοπός αυτός, σχεδιάστηκαν και υλοποιήθηκαν δύο πιλοτικές εκδοχές του προγράμματος στη βάση του μοντέλου PERMA (Seligman, 2011): η μία εκδοχή αποτελείτο από δώδεκα συναντήσεις διάρκειας ογδόντα λεπτών και η δεύτερη εκδοχή, η οποία αποτελείτο από πέντε συναντήσεις διάρκειας δυόμιση ωρών η καθεμία. Το πρόγραμμα βασίστηκε σε έξι πυλώνες: Θετικά Συναισθήματα, Δυνατά στοιχεία του χαρακτήρα, Θετικές Σχέσεις, Ανθεκτικότητα, Νόημα και Επιτεύγματα. Χορηγήθηκαν ψυχομετρικά εργαλεία που μετρούν το ευ ζην (PERMA Profiler), τα συμπτώματα του στρες, του άγχους και της κατάθλιψης (DASS) και την ανθεκτικότητα (CD-RISC) πριν και μετά την παρέμβαση. Για τον έλεγχο της αποτελεσματικότητας του προγράμματος διενεργήθηκαν δύο πιλοτικές έρευνες. Η πρώτη μελέτη αφορούσε στον έλεγχο της αποτελεσματικότητας της υλοποίησης του προγράμματος μεγάλης διάρκειας σε τρεις ομάδες εκπαιδευτικών. Τα αποτελέσματα έδειξαν ότι η συμμετοχή των εκπαιδευτικών στο συγκεκριμένο πρόγραμμα ενίσχυσε όχι μόνο το ευ ζην, αλλά αύξησε επίσης και τα επίπεδα της ψυχικής τους ανθεκτικότητας. Η δεύτερη μελέτη είχε ως βασικό στόχο την εξέταση της αποτελεσματικότητας της δεύτερης εκδοχής του προγράμματος σε δύο ομάδες εκπαιδευτικών. Τα αποτελέσματα έδειξαν ότι ενισχύθηκε το ευ ζην των συμμετεχόντων στο πρόγραμμα αλλά επίσης παρατηρήθηκε μείωση και στο επίπεδο στρες. Ωστόσο, τα επίπεδα της ψυχικής τους ανθεκτικότητας δεν σημείωσαν μεταβολή. Συνολικά, τα ευρήματα της παρούσας διατριβής δείχνουν ότι το πρωτότυπο ψυχοεκπαιδευτικό πρόγραμμα που δημιουργήθηκε μπορεί να αποτελέσει χρήσιμο εργαλείο και στρατηγική αυτοδιαχείρισης για την ενίσχυση του ευ ζην των εκπαιδευτικών. Τα ευρήματα της διατριβής συζητήθηκαν ως προς τη συνεισφορά τους στην προαγωγή της επιστημονικής θεωρίας και έρευνας, στην εκπαίδευση και το χώρο εργασίας. Επιπλέον, συζητήθηκαν οι θεωρητικοί και μεθοδολογικοί περιορισμοί και διατυπώθηκαν προτάσεις για μελλοντικές έρευνες. Γενικά, και οι δύο εκδοχές του ψυχοεκπαιδευτικού προγράμματος οδήγησαν σε σημαντική αύξηση τόσο των επιμέρους διαστάσεων του PERMA, όσο και του συνολικού ευ ζην των συμμετεχόντων, γεγονός που επιφέρει σημαντική συνεισφορά κατά τον σχεδιασμό μελλοντικών εκπαιδευτικών προγραμμάτων που στοχεύουν στην ενίσχυση της ευζωίας των εκπαιδευτικών.
Temporomandibular joint disorders prevalence and health-seeking preferences among Al-Madinah community: A prospective cross sectional study
Authors: Alolayan Albraa , Alsayed Shayma S. , Salamah Ruwaa M. , Ali Khadija M. , Alsousi Mashael , Elsayed Shadia
Published: May 2023

Background:  Painful temporomandibular joint disorders (TMDs) are of musculoskeletal origin and are considered the most common cause of non-odontogenic pain in the orofacial region.  The purpose of this study was to investigate the prevalence and awareness of temporomandibular joint (TMJ) disorders in Almadinah Almunawwarah community.

Methods: A prospective observational cross-sectional study with convenience sampling was conducted. The patients were selected from the dental college and the hospital at Taibah University in Al-Madinah, Saudi Arabia.  A translated Arabic version of Fonseca's questionnaire was employed. The questionnaire asked about the participant's personal information, if they thought they had TMDs, and who to visit for therapy if necessary. These were followed by 10 items from Fonseca's questionnaire, each with a three-point scale.

Results: The questionnaire was completed by 518 people. Females made up 57.1% of the participants. TMDs were present in 61% of the population, with varying degrees of severity. Males (44.3%) were less affected than females (55.7%). The difference, however, was not statistically significant (P = 0.354). Out of the 61% TMDs Positive patients, 74.1% had mild TMDs symptoms, while 20.8% and 5.1%, respectively, had moderate and severe TMDs symptoms (P = 0.05). The severity of the symptoms was unaffected by demographic data (P > 0.05). Only 40% seek care, with 64.6% selecting for a dentist or orofacial pain specialists for their management  and 24.6% preferring for an orthopaedic specialist (P= 0.008).

Conclusions: Participants from Al-Madinah had a greater prevalence of mild TMDs. The majority of the participants had no idea who to go to for treatment. The findings of this study highlight the importance of educational activities to enhance public awareness
Integration of single-cell RNA-Seq and CyTOF data characterises heterogeneity of rare cell subpopulations
Authors: Repapi Emmanouela , Agarwal Devika , Napolitani Giorgio , Sims David , Taylor Stephen
Published: May 2023

Background: The simultaneous measurement of cellular proteins and transcriptomes of single cell data has become an exciting new possibility with the advent of highly multiplexed multi-omics methodologies. However, mass cytometry (CyTOF) is a well-established, affordable technique for the analysis of proteomic data, which is well suited for the discovery and characterisation of very rare subpopulations of cells with a wealth of publicly available datasets.

Methods: We present and evaluate the multimodal integration of single cell RNA-Seq and CyTOF datasets coming from both matched and unmatched samples, using two publicly available datasets.

Results: We demonstrate that the integration of well annotated CyTOF data with single cell RNA sequencing can aid in the identification and annotation of cell populations with high accuracy. Furthermore, we show that the integration can provide imputed measurements of protein markers which are comparable to the current gold standard of antibody derived tags (ADT) from CITE-Seq for both matched and unmatched datasets. Using this methodology, we identify and transcriptionally characterise a rare subpopulation of CD11c positive B cells in high resolution using publicly available data and we unravel its heterogeneity in a single cell setting without the need to sort the cells in advance, in a manner which had not been previously possible.

Conclusions: This approach provides the framework for using available proteomic and transcriptomic datasets in a unified and unbiased fashion to assist ongoing and future studies of cellular characterisation and biomarker identification.
Phytochemical profiling of Piper crocatum and its antifungal mechanism action as Lanosterol 14 alpha demethylase CYP51 inhibitor: a review
Authors: Siswina Tessa , Miranti Rustama Mia , Sumiarsa Dadan , Kurnia Dikdik
Published: May 2023

Mycoses or fungal infections are a general health problem that often occurs in healthy and immunocompromised people in the community. The development of resistant strains in Fungi and the incidence of azole antibiotic resistance in the Asia Pacific which reached 83% become a critical problem nowadays. To control fungal infections, substances and extracts isolated from natural resources, especially in the form of plants as the main sources of drug molecules today, are needed. Especially from Piperaceae, which have long been used in India, China, and Korea to treat human ailments in traditional medicine. The purpose of this review is to describe the antifungal mechanism action from Piper crocatum and its phytochemical profiling against lanosterol 14a demethylase CYP51. The methods used to search databases from Google Scholar to find the appropriate databases using Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) Flow Diagram as a clinical information retrieval method. From 1.150.000 results searched by database, there is 73 final results article to review. The review shows that P. crocatum contains flavonoids, tannins, terpenes, saponins, polyphenols, eugenol, alkaloids, quinones, chavibetol acetate, glycosides, triterpenoids or steroids, hydroxychavikol, phenolics, glucosides, isoprenoids, and non-protein amino acids. Its antifungal mechanisms in fungal cells occur due to ergosterol, especially lanosterol 14a demethylase (CYP51) inhibition, which is one of the main target sites for antifungal activity because it functions to maintain the integrity and function of cell membranes in Candida. P. crocatum has an antifungal activity through its phytochemical profiling against fungal by inhibiting the lanosterol 14a demethylase, make damaging cell membranes, fungal growth inhibition, and fungal cell lysis.
The association between the distance from the epicenter of the Haiti earthquake (2021) and medical diagnoses: A report from the field
Authors: Levy Einav , Alkan Michael , Shaul Sharon , Livni Gillerman Yael , Gidron Yori
Published: May 2023

Background: Following the earthquake of August 2021 in Haiti, humanitarian agencies provided support to the local population. NATAN, a voluntary based non-governmental organization, had arrived in the field five days after the earthquake and provided medical support based on a mobile clinic in seven villages close to the epicenter of the earthquake.

Methods: We conducted a cross-sectional study on data collected from 331 persons of concern, as part of ‘good clinical practice’. They received basic treatment such as antibiotics and minor surgical interventions following a diagnosis. The main variables that were collected in this intervention included demographic data, main diagnoses, and main treatments. We also examined the distance from the earthquake epicenter (DfE) and its effects on the diagnoses and treatments.

Results: Several interesting findings were observed. A significant association between the DfE and the diagnoses was found, where within the group closest to the epicenter, the most prevalent diagnosis was internal medicine problems (40.3%).

Conclusions: It is possible that since five days had passed since the earthquake, the expected diagnoses of traumatic injuries were reduced, leaving sub-acute problems to be diagnosed and treated.  Finally, mental health symptoms and stress levels should be assessed  systematically and with validated measures.
Assessment of work-related stress and burnout among clinical research occupations
Authors: Flores Luna Raul , De la Rocha Carmen , Cid López Marco Antonio , Venegas López Ivette , Gómez Méndez Sandra Carolina , López Romero Wendy , Alvarado García Brenda A. , Almeida Zarate Brandon A. , Mejía Morales Claudia
Published: May 2023

Background: Burnout syndrome is included by the World Health Organization (WHO) in the International Classification of Diseases, and it has a direct impact on the health of workers and also on the performance of companies. In this work, we propose a comprehensive methodology for evaluating work stress and burnout in various occupations within a healthcare organization.

Methods: The work stress questionnaire and the Maslach Burnout Inventory were administered to employees of 7 different occupations within a company. The effect of the stressors is established using Cohen's d test, as well as the relationship between the main stressors, burnout and occupation.

Results: The results of the study indicated that medical service personnel had the highest levels of stress and burnout syndrome, but significant stress levels and burnout scores were also identified among finance, clinical operations, and marketing professionals.

Conclusions: Stress and burnout can vary by department, team, or individual in a company. Based on the study, it was concluded that a single approach to assessing stress and burnout may not provide a complete understanding, in fact, a better alternative is to assess each occupation specifically.
Control study of Musca domestica (Diptera, Muscidae) in Misan Province
Authors: Alsaad Rasha
Published: May 2023

Background: Houseflies are the most common type of Diptera, specifically Muscidae, worldwide, representing more than 90% of all species. This family has over 170 genera and 4200 species, but a few are of medical significance. This study aimed to estimate and assessing the measures to control and prevent grow-up inside houses and flying of the housefly (Musca domestica Linnaeus, 1758) in Misan.

Methods: The study occurred over 12 months, from December 2020 to December 2021. Using plastic containers, Musca flies were collected from all potential breeding sites in the study region (inside and around houses). Sticky oil paper and traps were used to collect the insects. The collected insects were transferred to sealed plastic containers and then to the laboratory of the Department of Microbiology.

Results: Out of 200 randomly selected houses, 150 (75%) contained insects. Light traps and sticky oil papers were the most effective control measures, with 26.7% and 25.9% of the Musca collected from these methods, respectively. The ratio of male (233) to female (456) Musca was 1:2, with a significant difference between the frequencies (P<0.05). A large population of houseflies was collected during the hot season (501, 72.7%), whereas fewer Musca were collected during the cold months (188, 27.3%), with a strongly significant difference (P<0.05). The percentage of HI was 54.4%, the CI was 21.9%, and the BI was 79.9%. The overall larval densities (LD) were at a medium level.

Conclusions: Misan has a high density of Musca houseflies, with females being more prominent than males. Hot climate, humid sites, and dirty places are responsible for the breeding of houseflies. The overall larval density was medium. Therefore, the risk of transmitting infectious diseases by houseflies is high within the boundaries of Misan province, and effective control parameters should include measures like light traps and sticky oil.
In-air Hand Gesture Signature Recognition: An iHGS Database Acquisition Protocol
Authors: Khoh Wee How , Pang Ying Han , Yap Hui Yen
Published: May 2023

Background: With the advances in current technology, hand gesture recognition has gained considerable attention. It has been extended to recognize more distinctive movements, such as a signature, in human-computer interaction (HCI) which enables the computer to identify a person in a non-contact acquisition environment. This application is known as in-air hand gesture signature recognition. To our knowledge, there are no publicly accessible databases and no detailed descriptions of the acquisitional protocol in this domain.

Methods: This paper aims to demonstrate the procedure for collecting the in-air hand gesture signature’s database. This database is disseminated as a reference database in the relevant field for evaluation purposes. The database is constructed from the signatures of 100 volunteer participants, who contributed their signatures in two different sessions. Each session provided 10 genuine samples enrolled using a Microsoft Kinect sensor camera to generate a genuine dataset. In addition, a forgery dataset was also collected by imitating the genuine samples. For evaluation, each sample was preprocessed with hand localization and predictive hand segmentation algorithms to extract the hand region. Then, several vector-based features were extracted.

Results: In this work, classification performance analysis and system robustness analysis were carried out. In the classification analysis, a multiclass Support Vector Machine (SVM) was employed to classify the samples and 97.43% accuracy was achieved; while the system robustness analysis demonstrated low error rates of 2.41% and 5.07% in random forgery and skilled forgery attacks, respectively.

Conclusions: These findings indicate that hand gesture signature is not only feasible for human classification, but its properties are also robust against forgery attacks.
The mutual benefits of comparing energy system models and integrated assessment models
Authors: Henke Hauke , Dekker Mark , Lombardi Francesco , Pietzcker Robert , Fragkos Panagiotis , Zakeri Behnam , Rodrigues Renato , Sitarz Joanna , Emmerling Johannes , Fattahi Amir , Dalla Longa Francesco , Tatarewicz Igor , Fotiou Theofano , Lewarski Michał , Huppmann Daniel , Kavvadias Kostas , van der Zwaan Bob , Usher Will
Published: May 2023

Background: The transition to a carbon neutral society such as that envisaged in the European Union Green Deal requires careful and comprehensive planning. Integrated assessment models (IAMs) and energy system models (ESMs) are both commonly used for policy advice and in the process of policy design. In Europe, a vast landscape of these models has emerged and both kinds of models have been part of numerous model comparison and model linking exercises. However, IAMs and ESMs have rarely been compared or linked with one another.

Methods: This study conducts an explorative comparison and identifies possible flows of information between 11 of the integrated assessment and energy system models in the European Climate and Energy Modelling Forum. The study identifies and compares regional aggregations and commonly reported variables We define harmonised regions and a subset of shared result variables that enable the comparison of results across the models.

Results: The results highlight similarities and differences on final electricity demand, electricity supply and hydrogen across three levels of aggregation. However, the differences between the regional aggregation of the models limit detailed analysis.

Conclusions: This first-of-its-kind comparison and analysis of modelling results across model type boundaries provides modellers and policymakers with a better understanding of how to interpret both IAM and ESM results. It also highlights the need for community standards for region definitions and information about reported variables to facilitate future comparisons of this kind.
Drivers of Resistance in Uganda and Malawi (DRUM): a protocol for the evaluation of One-Health drivers of Extended Spectrum Beta Lactamase (ESBL) resistance in Low-Middle Income Countries (LMICs)
Authors: Cocker Derek , Sammarro Melodie , Chidziwisano Kondwani , Elviss Nicola , Jacob Shevin T. , Kajumbula Henry , Mugisha Lawrence , Musoke David , Musicha Patrick , Roberts Adam P. , Rowlingson Barry , Singer Andrew C. , Byrne Rachel L. , Edwards Thomas , Lester Rebecca , Wilson Catherine N. , Hollihead Beth , Thomson Nicholas R. , Jewell Christopher P. , Morse Tracy , Feasey Nicholas A.
Published: May 2023

In sub-Saharan Africa (sSA), there is high morbidity and mortality from severe bacterial infection and this is compounded by antimicrobial resistance, in particular, resistance to 3rd-generation cephalosporins. This resistance is typically mediated by extended-spectrum beta lactamases (ESBLs). To interrupt ESBL transmission it will be important to investigate how human behaviour, water, sanitation, and hygiene (WASH) practices, environmental contamination, and antibiotic usage in both urban and rural settings interact to contribute to transmission of ESBL E. coli and ESBL K. pneumoniae between humans, animals, and the environment.

Here we present the protocol for the Drivers of Resistance in Uganda and Malawi (DRUM) Consortium, in which we will collect demographic, geospatial, clinical, animal husbandry and WASH data from a total of 400 households in Uganda and Malawi. Longitudinal human, animal and environmental sampling at each household will be used to isolate ESBL E. coli and ESBL K. pneumoniae. This will be complimented by a Risks, Attitudes, Norms, Abilities and Self-Regulation (RANAS) survey and structured observations to understand the contextual and psychosocial drivers of regional WASH practices.

Bacterial isolates and plate sweeps will be further characterised using a mixture of short-,long-read and metagenomic whole-genome sequencing. These datasets will be integrated into agent-based models to describe the transmission of EBSL resistance in Uganda and Malawi and allow us to inform the design of interventions for interrupting transmission of ESBL-bacteria.
Structure of the transmembrane protein 2 (TMEM2) ectodomain and its apparent lack of hyaluronidase activity
Authors: Niu Muyuan , McGrath Molly , Sammon Douglas , Gardner Scott , Morgan Rhodri Marc , Di Maio Antonio , Liu Yan , Bubeck Doryen , Hohenester Erhard
Published: May 2023

Background: Hyaluronic acid (HA) is a major polysaccharide component of the extracellular matrix. HA has essential functions in tissue architecture and the regulation of cell behaviour. HA turnover needs to be finely balanced. Increased HA degradation is associated with cancer, inflammation, and other pathological situations. Transmembrane protein 2 (TMEM2) is a cell surface protein that has been reported to degrade HA into ~5 kDa fragments and play an essential role in systemic HA turnover.

Methods: We produced the soluble TMEM2 ectodomain (residues 106-1383; sTMEM2) in human embryonic kidney cells (HEK293) and determined its structure using X-ray crystallography. We tested sTMEM2 hyaluronidase activity using fluorescently labelled HA and size fractionation of reaction products. We tested HA binding in solution and using a glycan microarray.

Results: Our crystal structure of sTMEM2 confirms a remarkably accurate prediction by AlphaFold. sTMEM2 contains a parallel β-helix typical of other polysaccharide-degrading enzymes, but an active site cannot be assigned with confidence. A lectin-like domain is inserted into the β-helix and predicted to be functional in carbohydrate binding. A second lectin-like domain at the C-terminus is unlikely to bind carbohydrates. We did not observe HA binding in two assay formats, suggesting a modest affinity at best. Unexpectedly, we were unable to observe any HA degradation by sTMEM2. Our negative results set an upper limit for kcat of approximately 10-5 min-1.

Conclusions: Although sTMEM2 contains domain types consistent with its suggested role in TMEM2 degradation, its hyaluronidase activity was undetectable. HA degradation by TMEM2 may require additional proteins and/or localisation at the cell surface.
Especie humana y naturaleza: El vínculo roto.
Authors: Troncoso Campos Adrián José
Published: May 2023

El autor investiga sobre el impacto ejercido por la especie humana sobre el Medio Ambiente ya desde los primeros tiempos, lo que ha llegado a producir la ruptura del hombre con la naturaleza: el Vínculo Roto. Estudia asimismo la vinculación natural del hombre con el arte y cómo la naturaleza es consustancial a toda manifestación artística desde la Prehistoria, abordando también los problemas ecológicos más cruciales y aún remediables a medio plazo, para favorecer mediante programas interdisciplinares un cambio de actitud y mentalidad en la especie humana a través de la educación y de una nueva cultura y filosofía medioambiental, donde el binomio Naturaleza-arte, ya sea plástico, cinematográfico, literario ... jugará un papel fundamental.
Modernismo, música y literatura: “La habitación propia” de Virginia Woolf y Etherl Smyth.
Authors: Camino Navarro Consolación
Published: May 2023

La relevancia que la historiografía ha atribuido a una figura como Ethel Smyth (1858-1944) reside en que fue la primera mujer que compuso y estrenó una ópera, Fantasio (1898), y en el referente que dicha compositora supuso para el movimiento feminista de su época, llegando incluso a influenciar a la afamada escritora Virginia Woolf (1882-1941), quien hasta el momento no había reflejado una notoria literatura política en su obra. Ambas mujeres son consideradas como las precursoras del modernismo inglés en sus respectivos campos artísticos y este artículo refleja cómo gracias al contacto que estas mantuvieron en vida, enriquecieron las características de esta corriente, además de contribuir a la necesaria geanología artística femenina.
ERCILIA, el nombre griego de la poetisa Antonia Díaz en los versos de Lamarque de Novoa.
Authors: Troncoso García Jesús
Published: May 2023

Jesús Troncoso, autor del presente artículo, descubre que la poetisa Antonia Díaz, la juvenil amiga y posterior amantísima esposa del poeta Lamarque de Novoa aparece en sus versos arropada bajo el seudónimo griego de Ercilia en varios poemas recogidos a m0do de antología en sus Poesías Líricas de 1895. En ellos se observa la evolución de un excelso amor idealizado que asciende desde la amistad hasta su dolorosa muerte en un romántico escenario modernista: el palacete de la Alquería del Pilar, construido para el disfrute de su amada en Dos Hermanas.
Abuso del derecho de asociación sindical. El caso colombiano
Authors: Quintero Martínez Saida Andrea
Published: May 2023

Este libro expone la realidad del movimiento sindical en Colombia evi-denciando una paradoja: un incremento exponencial de sindicatos, pero con una tasa afiliación que no crece y se mantiene alrededor del 5 %. Con estadísticas sólidas, la autora evidencia malas prácticas generadas por la creación de sindicatos con los mismos afiliados, así como la proliferación de fueros sindicales. De igual modo, examina otras situaciones de abuso como las dificultades para levantar los fueros por las demoras en procesos judiciales, consecuencia de la estrategia dilatoria de sindicatos; abusos en permisos y auxilios sindicales; violación al derecho negativo de asociación; abusos de algunos sindicatos por negarse a resolver el conflicto colectivo y retirar a conveniencia el pliego de peticiones.
Recursive Importance Sketching for Rank Constrained Least Squares: Algorithms and High-Order Convergence
Authors: Luo Yuetian , Huang Wen , Li Xudong , Zhang Anru
Published: May 2023

Solving Rank Constrained Least Squares via Recursive Importance Sketching

In statistics and machine learning, we sometimes run into the rank-constrained least squares problems, for which we need to find the best low-rank fit between sets of data, such as trying to figure out what factors are affecting the data, filling in missing information, or finding connections between different sets of data. This paper introduces a new method for solving this problem called the recursive importance sketching algorithm (RISRO), in which the central idea is to break the problem down into smaller, easier parts using a unique technique called “recursive importance sketching.” This new method is not only easy to use, but it is also very efficient and gives accurate results. We prove that RISRO converges in a local quadratic-linear and quadratic rate under some mild conditions. Simulation studies also demonstrate the superior performance of RISRO.
PENGARUH ZAKAT DAN MODAL INTELEKTUAL PADA KINERJA PERBANKAN SYARIAH DI INDONESIA
Authors: Salampessy Andy Passyada
Published: May 2023

The banking industry, especially Islamic Banking in Indonesia, experiences rapid yearly development. This development is influenced by increasing performance. This study aims to examine the effect of zakat and intellectual capital on the performance of Islamic Banking in Indonesia. The sampling technique used was the purposive sampling method. Data obtained from the annual report of Islamic Banking in Indonesia registered with The Central Bank of Republic of Indonesia and The Financial Services Authority from 2011-2020. Data analysis is carried out with validity tests, reliability tests, and hypothesis tests with the help of SPSS applications. The results showed that zakat and intellectual capital variables proved to have no effect on the performance of Islamic Banking in Indonesia for the 2011-2020 period.
PERAN KECERDASAN EMOSIONAL SEBAGAI VARIABEL PEMODERASI PADA PENGARUH KONFLIK PEKERJAAN KELUARGA TERHADAP KESEJAHTERAAN
Authors: Khoirunnisa Rikha Muftia , Rizky Kusuma Desta , Rahmi Mustika
Published: May 2023

Work and family life are two domains of human activity where people spend two-thirds of their lives in these two domains. Each individual has a role in each of these domains and strive to be able to fulfill its role. However, when one role demands more attention it will interfere with the fulfillment of the other role. This study aims to determine the effect of work-family conflict on welfare. Then this study will examine the role of moderating emotional intelligence on these influences. The sample in this study were all Ahmad Dahlan University Hospital employees, amounting to 104 people. The sampling technique used in this study is saturated sampling. The research data was obtained through a questionnaire filled out by Ahmad Dahlan University Hospital employees. Hypothesis testing uses multiple regression and multilevel regression (hierarchy). The results showed that work-family conflict and emotional intelligence affect welfare. However, the effect of moderating emotional intelligence on the effect of work-family conflict on well-being is not proven.
PENGUKURAN KINERJA SUMBER DAYA MANUSIA MENGGUNAKAN METODE HUMAN RESOURCE SCORECARD
Authors: Karlina Aulia , Samanhudi Didi
Published: May 2023

In recent research, employee performance evaluations have not been carried out comprehensively. However, problems related to employee performance are the increasing number of complaints and the achievement of project targets on time. This study aims to determine the level of employee performance and provide suggestions for improving  key performance indicator (KPI) below the target. The sampling method is non-probability sampling with purposive sampling. The method used is the Human Resource Scorecard (HRS) supported by the Analytical Hierarchy Process (AHP) and Traffic Light System (TLS). The results showed that the performance measurement score of PT. Modern Pulsa Investama in 2021 is 2,23 (less) with a TLS of 2,90; in 2022, it is 2,99 (medium), with a TLS of 5,86, indicating satisfactory performance. Based on 15 KPIs in 2021, 4 were obtained in the green group, 5 in the yellow group, and 6 in the red group. Of the 15 KPIs in 2022, 6 were obtained in the green group, 6 in the yellow group, and 3 in the red group. KPIs that go on a yellow to red scale are the focus of improvement. PT. Modern Pulsa Investama is a company that develops bill payment applications and online product purchases.