bluuebunny/crossref_metadata_2025 huggingface dataset:
Sonothrombolysis in Acute Ischemic Stroke: Current Status
Authors: Sharma Arvind , Navarro Jose C. , Escabillas Cyrus G. , Sharma Vijay K.
Published: August 2018

Transcranial Doppler (TCD) is an important tool in the armamentarium of stroke neurologists. This, bedsides modality, can help in establishing the presence, location, and severity of intracranial arterial occlusion in acute stroke cases. Various hemodynamic consequences of an acute arterial occlusion such as flow diversion and compensatory flow increase in other intracranial arteries can be monitored by TCD with reasonable accuracy. TCD monitoring during intravenous thrombolysis may demonstrate recanalization in real-time In addition, continuous ultrasound exposure during intravenous thrombolysis can enhance the rates of the recanalization of an acutely occluded intracranial artery. Therapeutic ultrasound or sonothrombolysis remains a widely debated application of TCD. We present the available evidence for sonothrombolysis as well as its current status in the hyperacute treatment of acute ischemic stroke.
Stroke Care Services in Brazil
Authors: Silva Gisele Sampaio , Rocha Eva Carolina Andrade , Pontes-Neto Octavio Marques , Martins Sheila Ouriques
Published: August 2018

The burden of stroke in Brazil, as in other developing countries, has considerably increased over the past years. With incidence rates ranging from 105 to 137 cases per 100 000 persons per year and mortality reaching 24%, stroke is a major public health issue in this continental country. Although most strokes in Brazil can be attributed to classic treatable cardiovascular risk factors, infectious diseases such as Chagas disease, arboviruses hemorrhagic fevers, neurocysticercosis, and malaria are also important risk factors. Socioeconomic disparities and population unawareness about stroke symptoms are great challenges in Brazil. There was an improvement in stroke awareness after the Brazilian Stroke Society and the World Stroke Organization launched several campaigns throughout the country. Another important step was taken in 2012, when the Brazilian Ministry of Health published the Brazilian National Stroke Act, including reimbursement for rtPA, creation of stroke centers qualified according to the hospital complexity, integration of the Brazilian Emergency Medical System, establishment of a budget for the rehabilitation system, and education and training of healthcare professionals and of the population. Since these measures, the number of stroke centers increased from 35 in 2008 to 149 in 2017 and stroke mortality in public stroke centers decreased from 17.9% in 2010 to 12.8% in 2014. Although much has improved, Brazil still has major social inequalities and further measures are needed to guarantee a high-quality stroke care.
Improving Undergraduate Life Science Education for the Biosciences Workforce: Overcoming the Disconnect between Educators and Industry
Authors: Thompson Christopher , Sanchez Joseph , Smith Michael , Costello Judy , Madabushi Amrita , Schuh-Nuhfer Natasha , Miranda Rommel , Gaines Brian , Kennedy Kathleen , Tangrea Michael , Rivers David
Published: August 2018

The BioHealth Capital Region (Maryland, Virginia, and Washington, DC; BHCR) is flush with colleges and universities training students in science, technology, engineering, and mathematics disciplines and has one of the most highly educated workforces in the United States. However, current educational approaches and business recruitment tactics are not drawing sufficient talent to sustain the bioscience workforce pipeline. Surveys conducted by the Mid-Atlantic Biology Research and Career Network identified a disconnect between stakeholders who are key to educating, training, and hiring college and university graduates, resulting in several impediments to workforce development in the BHCR: 1) students are underinformed or unaware of bioscience opportunities before entering college and remain so at graduation; 2) students are not job ready at the time of graduation; 3) students are mentored to pursue education beyond what is needed and are therefore overqualified (by degree) for most of the available jobs in the region; 4) undergraduate programs generally lack any focus on workforce development; and 5) few industry–academic partnerships with undergraduate institutions exist in the region. The reality is that these issues are neither surprising nor restricted to the BHCR. Recommendations are presented to facilitate improvement in the preparation of graduates for today’s bioscience industries throughout the United States.
A comparative study of texture attributes for characterizing subsurface structures in seismic volumes
Authors: Long Zhiling , Alaudah Yazeed , Ali Qureshi Muhammad , Hu Yuting , Wang Zhen , Alfarraj Motaz , AlRegib Ghassan , Amin Asjad , Deriche Mohamed , Al-Dharrab Suhail , Di Haibin
Published: August 2018

We have explored how to computationally characterize subsurface geologic structures presented in seismic volumes using texture attributes. For this purpose, we conduct a comparative study of typical texture attributes presented in the image processing literature. We focus on spatial attributes in this study and examine them in a new application for seismic interpretation, i.e., seismic volume labeling. For this application, a data volume is automatically segmented into various structures, each assigned with its corresponding label. If the labels are assigned with reasonable accuracy, such volume labeling will help initiate an interpretation process in a more effective manner. Our investigation proves the feasibility of accomplishing this task using texture attributes. We also identify the advantages and disadvantages associated with each attribute.
Psychotherapeutic leadership and containment in psychiatry
Authors: Gibson Russell , Till Alex , Adshead Gwen
Published: August 2018

Leadership is a key role for psychiatrists, with many models that can be adopted depending in part on the nature of the individual and their training, the primary task of the team and the nature of the organisation. In this article we suggest a new concept and model of leadership, ‘psychotherapeutic leadership’. We discuss the theoretical background to this model, its benefits and the implications for training and professional development.

LEARNING OBJECTIVES

•

Understand the concept and role of the psychiatrist in providing psychotherapeutic leadership at an individual patient, team and organisational level

•

Explore how applying an understanding of psychodynamic principles in practice can provide containment in psychiatry and aid clinical leadership

•

Understand the role of psychotherapeutically informed approaches in recognising factors influencing staff morale and burnout

DECLARATION OF INTEREST

None.
Disorganisation, thought disorder and socio-cognitive functioning in schizophrenia spectrum disorders
Authors: de Sousa Paulo , Sellwood William , Griffiths Martin , Bentall Richard P.
Published: August 2018

Background

Poor social cognition is prevalent in schizophrenia spectrum disorders. Some authors argue that these effects are symptom-specific and that socio-cognitive difficulties (e.g. theory of mind) are strongly associated with thought disorder and symptoms of disorganisation.

Aims

The current review tests the strength of this association.

Method

We meta-analysed studies published between 1980 and 2016 that tested the association between social cognition and these symptoms in schizophrenia spectrum disorders.

Results

Our search (PsycINFO, MEDLINE and Web of Science) identified 123 studies (N= 9107). Overall effect size asr= −0.313, indicating a moderate association between symptoms and social cognition. Subanalyses yielded a moderate association between symptoms and theory of mind (r= −0.349) and emotion recognition (r= −0.334), but smaller effect sizes for social perception (r= −0.188), emotion regulation (r= −0.169) and attributional biases (r= −0.143).

Conclusions

The association is interpreted within models of communication that highlight the importance of mentalisation and processing of partner-specific cues in conversational alignment and grounding.

Declaration of interests

None.
Effects of Altering Levothyroxine Dose on Energy Expenditure and Body Composition in Subjects Treated With LT4
Authors: Samuels Mary H , Kolobova Irina , Niederhausen Meike , Purnell Jonathan Q , Schuff Kathryn G
Published: August 2018

Background

It is unclear whether variations in thyroid status within or near the reference range affect energy expenditure, body mass, or body composition.

Methods

138 subjects treated with levothyroxine (LT4) for hypothyroidism with normal TSH levels underwent measurement of total, resting, and physical activity energy expenditure; thermic effect of food; substrate oxidation; dietary intake; and body composition. They were assigned to receive an unchanged, higher, or lower LT4 dose in randomized, double-blind fashion, targeting one of three TSH ranges (0.34 to 2.50, 2.51 to 5.60, or 5.61 to 12.0 mU/L). The doses were adjusted every 6 weeks to achieve target TSH levels. Baseline measures were reassessed at 6 months.

Results

At study end, the mean LT4 doses and TSH levels were 1.50 ± 0.07, 1.32 ± 0.07, and 0.78 ± 0.08 µg/kg (P < 0.001) and 1.85 ± 0.25, 3.93 ± 0.38, and 9.49 ± 0.80 mU/L (P < 0.001), respectively, in the three arms. No substantial metabolic differences in outcome were found among the three arms, although direct correlations were observed between decreases in thyroid status and decreases in resting energy expenditure for all subjects. The subjects could not ascertain how their LT4 dose had been adjusted but the preferred LT4 dose they perceived to be higher (P < 0.001).

Conclusions

Altering LT4 doses in subjects with hypothyroidism to vary TSH levels in and near the reference range did not have major effects on energy expenditure or body composition. Subjects treated with LT4 preferred the perceived higher LT4 doses despite a lack of objective effect. Our data do not support adjusting LT4 doses in patients with hypothyroidism to achieve potential improvements in weight or body composition.
Time to Separate Persistent From Recurrent Differentiated Thyroid Cancer: Different Conditions With Different Outcomes
Authors: Sapuppo Giulia , Tavarelli Martina , Belfiore Antonino , Vigneri Riccardo , Pellegriti Gabriella
Published: August 2018

Context

Differentiated thyroid cancer (DTC) has an excellent prognosis, but up to 20% of patients with DTC have disease events after initial treatment, indistinctly defined as persistent/recurrent disease.

Objective

To evaluate the prevalence and outcome of “recurrent” disease (relapse after being 12 months disease-free) compared with “persistent” disease (present ab initio since diagnosis).

Design

Retrospective analysis of persistent/recurrent disease in patients with DTC (1990 to 2016) with 6.5 years of mean follow-up.

Setting

Tertiary referral center for thyroid cancer.

Patients

In total, 4292 patients all underwent surgery ± 131I treatment of DTC.

Main Outcome Measures

DTC cure of disease persistence or recurrence.

Results

A total of 639 of 4292 (14.9%) patients had disease events after initial treatment, most (498/639, 78%) with persistent disease and 141 (22%) with recurrent disease. Relative to patients with recurrent disease, patients with persistent disease were significantly older (mean age 46.9 vs 45.7 years) and with a lower female to male ratio (1.9/1 vs 4.8/1). Moreover, in this group, structured disease was more frequent (65.7% vs 41.1%), and more important, distant metastases were significantly more frequent (38.4% vs 17.0%). At multivariate analysis, male sex (OR = 1.7), age (OR = 1.02), follicular histotype (OR = 1.5), T status (T3; OR = 3), and N status (N1b; OR = 7.7) were independently associated with persistent disease. Only the N status was associated with recurrent disease (N1b; OR = 2.5).

Conclusions

In patients with DTC not cured after initial treatment, persistent disease is more common and has a worse outcome than recurrent disease. Postoperative status evaluated during first-year follow-up may have important clinical implications for planning tailored treatment strategies and long-term follow-up procedures.
MicroRNA-dependent regulation of Hox gene expression sculpts fine-grain morphological patterns in a Drosophila appendage
Authors: Kaschula Richard , Pinho Sofia , Alonso Claudio R.
Published: August 2018

Disruptions of normal Hox gene expression can lead to severe morphological defects, revealing a link between the regulation of Hox expression and pattern formation. Here, we explore these links, focusing on the impact of microRNA regulation on the expression of the Drosophila Hox gene Ultrabithorax (Ubx) during haltere development. Through a combination of bioinformatic and transcriptomic analyses, we identify the miR-310/313 cluster (miR-310C) as a candidate regulator of Ubx. Several experiments confirm this. First, miR-310C and Ubx protein show complementary expression patterns in haltere imaginal discs; second, artificial activation of miR-310C expression in haltere discs leads to Ubx-like phenotypes. Third, expression of a fluorescent reporter bearing Ubx 3′UTR sequences is reduced when co-expressed with miR-310C. Fourth, deletion of miR-310C leads to Ubx upregulation and changes the array of mechanosensory sensilla at the base of the haltere. Fifth, an artificial increase of Ubx levels within the miR-310C expression domain phenocopies the mechanosensory defects observed in miR-310C mutants. We propose that miR-310C-mediated repression delimits Ubx fine-grain expression, contributing to the sculpting of complex morphologies in the Drosophila haltere with implications for flight control. Our work reveals a novel role of microRNA regulation in the control of Hox gene expression with impact on morphology.
Pitx2 maintains mitochondrial function during regeneration to prevent myocardial fat deposition
Authors: Li Lele , Tao Ge , Hill Matthew C. , Zhang Min , Morikawa Yuka , Martin James F.
Published: August 2018

Loss of the paired-like homeodomain transcription factor 2 (Pitx2) in cardiomyocytes predisposes mice to atrial fibrillation and compromises neonatal regenerative capacity. In addition, Pitx2 gain-of-function protects mature cardiomyocytes from ischemic injury and promotes heart repair. Here, we characterized the long-term myocardial phenotype following myocardial infarction (MI) in Pitx2 conditional-knockout (Pitx2 CKO) mice. We found adipose-like tissue in Pitx2 CKO hearts 60 days after MI induced surgically at postnatal day 2 but not at day 8. Molecular and cellular analyses showed the onset of adipogenic signaling in mutant hearts after MI. Lineage tracing experiments showed a non-cardiomyocyte origin of the de novo adipose-like tissue. Interestingly, we found that Pitx2 promotes mitochondrial function through its gene regulatory network, and that the knockdown of a key mitochondrial Pitx2 target gene, Cox7c, also leads to the accumulation of myocardial fat tissue. Single-nuclei RNA-seq revealed that Pitx2-deficient hearts were oxidatively stressed. Our findings reveal a role for Pitx2 in maintaining proper cardiac cellular composition during heart regeneration via the maintenance of proper mitochondrial structure and function.
Challenges and approaches to predicting RNA with multiple functional structures
Authors: Schroeder Susan J.
Published: August 2018

The revolution in sequencing technology demands new tools to interpret the genetic code. As in vivo transcriptome-wide chemical probing techniques advance, new challenges emerge in the RNA folding problem. The emphasis on one sequence folding into a single minimum free energy structure is fading as a new focus develops on generating RNA structural ensembles and identifying functional structural features in ensembles. This review describes an efficient combinatorially complete method and three free energy minimization approaches to predicting RNA structures with more than one functional fold, as well as two methods for analysis of a thermodynamics-based Boltzmann ensemble of structures. The review then highlights two examples of viral RNA 3′-UTR regions that fold into more than one conformation and have been characterized by single molecule fluorescence energy resonance transfer or NMR spectroscopy. These examples highlight the different approaches and challenges in predicting structure and function from sequence for RNA with multiple biological roles and folds. More well-defined examples and new metrics for measuring differences in RNA structures will guide future improvements in prediction of RNA structure and function from sequence.
Spontaneous HTLV-1 transcription is accompanied by distinct epigenetic changes in the 5′ and 3′ long terminal repeats
Authors: Miura Michi , Miyazato Paola , Satou Yorifumi , Tanaka Yuetsu , Bangham Charles R.M.
Published: August 2018

Background:The human retrovirus HTLV-1 inserts the viral complementary DNA of 9 kb into the host genome. Both plus- and minus-strands of the provirus are transcribed, respectively from the 5′ and 3′ long terminal repeats (LTR). Plus-strand expression is rapid and intense once activated, whereas the minus-strand is transcribed at a lower, more constant level. To identify how HTLV-1 transcription is regulated, we investigated the epigenetic modifications associated with the onset of spontaneous plus-strand expression and the potential impact of the host factor CTCF.

Methods:Patient-derived peripheral blood mononuclear cells (PBMCs) and in vitro HTLV-1-infected T cell clones were examined. Cells were stained for the plus-strand-encoded viral protein Tax, and sorted into Tax+and Tax–populations. Chromatin immunoprecipitation and methylated DNA immunoprecipitation were performed to identify epigenetic modifications in the provirus. Bisulfite-treated DNA fragments from the HTLV-1 LTRs were sequenced. Single-molecule RNA-FISH was performed, targeting HTLV-1 transcripts, for the estimation of transcription kinetics. The CRISPR/Cas9 technique was applied to alter the CTCF-binding site in the provirus, to test the impact of CTCF on the epigenetic modifications.

Results:Changes in the histone modifications H3K4me3, H3K9Ac and H3K27Ac were strongly correlated with plus-strand expression. DNA in the body of the provirus was largely methylated except for the pX and 3′ LTR regions, regardless of Tax expression. The plus-strand promoter was hypomethylated when Tax was expressed. Removal of CTCF had no discernible impact on the viral transcription or epigenetic modifications.

Conclusions:The histone modifications H3K4me3, H3K9Ac and H3K27Ac are highly dynamic in the HTLV-1 provirus: they show rapid change with the onset of Tax expression, and are reversible. The HTLV-1 provirus has an intrinsic pattern of epigenetic modifications that is independent of both the provirus insertion site and the chromatin architectural protein CTCF which binds to the HTLV-1 provirus.
AUTHENTIC TELEVISION MATERIALS IN THE PRACTICE OF TEACHING RUSSIAN AS A FOREIGN LANGUAGE: METHODICAL DEVELOPING A LESSON BASED ON A TV REPORTAGE
Authors: Безрукова Ольга , Bezrukova Ol'ga
Published: August 2018

The article is devoted to the issues of practical use of authentic TV materials at the lessons of Russian as a foreign language. The methodical model of work with authentic television material is considered, the author’s methodical developing of a lesson on the base of original TV reportage is presented
Inconsistent Models (and Infinite Models) for Arithmetics with Constructible Falsity
Authors: Ferguson Thomas Macaulay
Published: August 2018

An earlier paper on formulating arithmetic in a connexive logic ended with a conjecture concerning C♯ , the closure of the Peano axioms in Wansing’s connexive logic C. Namely, the paper conjectured that C♯ is Post consistent relative to Heyting arithmetic, i.e., is nontrivial if Heyting arithmetic is nontrivial. The present paper borrows techniques from relevant logic to demonstrate that C♯ is Post consistent simpliciter, rendering the earlier conjecture redundant. Given the close relationship between C and Nelson’s paraconsistent N4, this also supplements Nelson’s own proof of the Post consistency of N4♯ . Insofar as the present technique allows infinite models, this resolves Nelson’s concern that N4♯ is of interest only to those accepting that there are finitely many natural numbers.
Greedy-Like Algorithms for Dynamic Assortment Planning Under Multinomial Logit Preferences
Authors: Aouad Ali , Levi Retsef , Segev Danny
Published: August 2018

We study the joint assortment planning and inventory management problem, where stock-out events elicit dynamic substitution effects, described by the multinomial logit (MNL) choice model. Special cases of this setting have been extensively studied in recent literature, notably the static assortment planning problem. Nevertheless, to our knowledge, the general formulation is not known to admit efficient algorithms with analytical performance guarantees before this work, and most of its computational aspects are still wide open.

In this paper, we devise what is, to our knowledge, the first provably good approximation algorithm for dynamic assortment planning under the MNL model. We derive a constant-factor guarantee for a broad class of demand distributions that satisfy the increasing failure rate property. Our algorithm relies on a combination of greedy procedures, where stocking decisions are restricted to specific classes of products and the objective function takes modified forms. We demonstrate that our approach substantially outperforms state-of-the-art heuristic methods in terms of performance and speed, leading to an average revenue gain of 4% to 12% in computational experiments. In the course of establishing our main result, we develop new algorithmic ideas that may be of independent interest. These include weaker notions of submodularity and monotonicity, shown sufficient to obtain constant-factor worst-case guarantees, despite using noisy estimates of the objective function.
Improving end-of-life care in an intensive care unit: a collaborative quality improvement project
Authors: Le François Lisa , Tapp Diane
Published: August 2018

Background:

The shift from curative to palliative care is one of the most challenging situations in intensive care units.

Aims:

The purpose of this collaborative project was to develop and implement a pilot intervention aimed at improving end-of-life care for patients in an open intensive care unit in Quebec City, Canada.

Methods:

Individual and group interviews were first conducted to identify strengths and needs for improvement in care. After the main needs for improvement were determined, interventions were implemented in a concerted manner. These included training in end-of-life care as well as the adaptation of tools to promote communication with the patient and his or her family, or to facilitate interdisciplinary work.

Results:

Preliminary results obtained through individual interviews indicate participant satisfaction with the project, but additional data need to be gathered to evaluate improvements in practice.

Conclusions:

Other collaborative quality improvement projects need to be implemented to improve end-of-life practices in intensive care units.
Research roundup
Authors: Heggs Karen
Published: August 2018

Synopses of a selection of recently published research articles of relevance to palliative care
LARVAL DEVELOPMENT OF THE INDONESIAN BLUE SWIMMING CRAB, PORTUNUS PELAGICUS (L) (CRUSTACEA : DECAPODA : PORTUNIDAE) REARED IN THE LABORATORY
Authors: Juwana Sri , Aswandy Indra , Pangabean M.G. Lily
Published: August 2018

A number of 137,870 freshly hatched larvae of Portunus pelagicus (L) were reared in one thousand litre container. The combination of Brachionus plicatilis and newly hatched nauplii of Artemia salina were fed to the larvae. The number of megalopa obtained was only 277. Ecological factor such as temperature, salinity, pH and dissolved oxygen were recorded. The effect of different food sources of the previous authors are compared. The detail description of the four zoeal stages and one megalopal stage are made and figured with emphasis on the number and type of setae on each appendages. A pattern of zoeal chromatophores is also sketched and described.
WATER QUALITY INDICATOR BACTERIA IN BENGAWAN SOLO AND PORONG RIVERS AND THEIR ESTUARIES
Authors: Thayib Soeminarti S. , Ruyitno - , Kunarso Djoko Hadi , Razak Hamidah
Published: August 2018

Water samples taken from rivers and estuaries stations in Bengawan Solo and Porong rivers in East Java were analyzed for the pollution of indicator bacteria in July-August and NovemberDecember 1984, to determine the influences of domestic wastes on the quality of these waters. Higher frequency of occurrences of high total coliform, fecal coli and fecal streptococci were observed in water samples collected in river stations, river mouths and in the vicinity of dense populated areas. The distribution of saprophytes, freshwater bacteria and indicator bacteria were also studied. The changes in the bacterial population as funciton of the salinity were shown during the observations. Some pathogenic bacteria like Salmonella, Yarsinia, and Vibrio parahaemolyticus and others have been isolated from waste and mud samples.
SEABIRDS IN THE BANDA SEA IN FEBRUARY/MARCH 1985
Authors: Cadee G. C.
Published: August 2018

Quantitative seabird data were collected in February/March 1985 in the Banda Sea. Comparison with similar data for August 1984 indicated no monsoonal influence on seabrid abundance; the median for both periods falls within the 1-5 birds per hour class.The area around the breeding island Manuk was relatively rich in both periods. Birds breeding here are "blue ocean" seabirds, foraging over large areas. Apparently, not food abundance but suitable breeding place determines their abundance here. Manuk has an enormous importance for the seabird population in the Banda Sea area, fortunately, it is a nature reserve since 1981. The breeding period on Manuk is not short and related to the NE monsoon, but extended over a larger period of the year. Manuk was known already as a breeding island in the 17th cnetury, but this knowledge was lost and only recently Manuk was "rediscovered" as such.A second relatively rich area occurred again south of Irian Jaya. Migrating birds dominated here. They probably visit this area because of relatively high food availability. Species differed for both periods. Streaked Shearwaters which breed on the northern hemisphere had in February/ March replaced the antarctic Wilson's Stormpetrel which abounded here in August 1984, but had now returned to its breeding area.
ECOTYPIC VARIATION IN GROWTH AND SURVIVAL TEMPERATURE OF CLADOPHORA VAGABUNDA (CHLOROPHYCEAE) ISOLATES FROM DIFFERENT CLIMATIC ZONES
Authors: Hatta Agus M. , Breeman A. M.
Published: August 2018

The effect of temperature on relative growth rates (RGR) and the ability to survive at stress temperatures have been investigated in isolates of the green algal species Cladophora vagabunda from Roscoff (Eastern Atlantic, temperate), Corsica (Mediterranean, subtropical), Western Australia (Indian Ocean, subtropical) and Curacao (Western Atlantic, tropical). Growth was observed between 1O°-35°C, except in the Roscoff isolate which grew between 10°-30°C and a temperature of 5°C was too low for growth in all isolates. Those indicate that all isolates were comparatively eurythermal. Variations in RGR were observed with a high maximum RGR in the W. Australian and Roscoff isolates with ca. 74% increase in length per day at 30°C, and a lower maximum RGR in the Corsican and Curacao isolates with ca. 30-50% increase in length per day at 20°-25°C. The broadest optimum range (between 15°-30°C) was shown by the Corsican isolate and the narrowest optimum range (between 25°-30°C) by the Curacao isolate. At a low stress temperature of 0°C, all isolates survived for at least 30 days without damage, after 30-50 days the Roscoff and Curacao isolates showed damage (cell bleaching) but they recovered at 20°C. The W. Australian and the Corsican isolates survived undamage for 60 days. At a high stress temperature of 35°C, the W. Australian and the Curacao isolates survived for 60 days, but the other two isolates died within 30 days. The different temperature responses of the isolates demonstrated the ability of Cladophora vagabunda to exist in varied temperature environments.
UPPER LAYER CIRCULATION IN THE BANDA SEA IN RESPONSE TO THE ONSET OF MONSOON WINDS
Authors: Hutahean W. , Wilson R. E.
Published: August 2018

Aspects of the upper layer circulation in the interior of the Banda Sea, Indonesia, associated with local forcing by monsoon winds are examined numerically through the use of a reduced gravity model. The basin is located between approximately 4°S and 8°S and is partially enclosed by chains of islands. The primary emphasis is an evaluation of the free wave response which contributes to the steady or slowly varying circulation. Basin response appears to be characterized by interacting Kelvin waves and Rossby at low frequencies, and by evanescent Poincare waves of higher frequencies. Passages between islands along the perimeter of the basin appear to be nearly, impermeable to Rossby waves, which contribute to a pattern of westward propagating quasi geostrophic eddies. This pattern would persist during periods of wind transition.
STUDY ON SEA LEVEL RISE IN THE WESTERN INDONESIA
Authors: Hadikusumah -
Published: August 2018

Study on mean sea level (MSL) rise has been done on tide data at some locations in the Western Indonesia. To account the effect of climate change, air temperature analyses from some weather stations are also performed. The results showed that air temperature has changed between 0.0 to 0.44°C per ten years. The sea level analysis showed that mean sea level at Western Indonesia rise between 3.10 to 9.27 mm per year. Based on the results, the prediction on mean sea level change in the years of 2000, 2030, 2050 and 2100 for Cirebon location are 17 cm, 39 cm, 55 cm, and 92 cm, respectively.
THE SUCCESSFUL TRANSPLANTATION OF ACROPORA MICROPHTHALMA AT BARRANG LOMPO REEF EDGE< SOUTH SULAWESI
Authors: Yuliantri A. R. , Moka W. , Jompa J. , Litaay M.
Published: August 2018

Research on transplantation of Acropora microphthalma was conducted at Barrang Lompo Island reef edge of South Sulawesi from September to December 2002. The aim of this research was to know the successful rate of several coral transplantation methods for rehabilitation of coral reefs, covering the survival and growth rates. The methods used were framework earthenware (FE), iron stake (IS), dead coral tying (DCT), where the mother colony (MC) was used as control. These transplantation techniques were applied at five meter depth in two stations, north and south sites of the island. The survival rate for each method FE, IS, DCT and MC at the northern station was 85.71; 42.86; 85.71; 57.14%, while for southern station was 85.71; 85.71; 71.43 and 85.71%, respectively. The growth rates observed for each method at the first station were 2.18; 2.02; 1.40; 1.05 cm, and for the second station were 2.56; 2.21; 1.61; 1.04 cm, respectively.
A FORMULATION APPROACH TO QUANTIFY THE ABUNDANCE OF CORAL GENERA
Authors: Suharsono - , Giyanto -
Published: August 2018

A formulation approach to quantify the abundance of coral genera is considered important to obtain basic information necessary in determining the potency and condition of coral, and one application can also be used to set quota for coral trade. The line intercept method has been used in five different area throughout Indonesian archipelago representing prestine area to heavy disturbances. Based on the number of occurrence, the genera dominance, the size of colony and the coral coverage in each study area was assigned scale, weight and value. The calculation gave the range of Total Value (TV) from 5 -20 and the assignment abundance category of coral genera is 17-20 very common, 14-16 common, 11-13 uncommon, 8 -10 rare, and 5-7 very rare. The categorization of each coral genus of certain area can be used to consider whether it can be harvested or not. Suggestion based on this study as follow: coral genera categorized as "very common" can be harvest, coral genera categorized as "common" can be harvest with caution, coral genera categorized as "uncommon", harvest are limited, coral genera as "rare", harvest are strictly limited and coral genera as "very rare" are prohibited to harvest.
EXPERIMENT ON FISSION STIMULATION OF HOLOTHURIA ARTA (HOLOTHUROIDEA, ECHINODERMATA): CHANGING IN BODY WEIGHT AND MORPHOLOGY
Authors: Purwati Pradina , Dwiono Sigit A.P.
Published: August 2018

Experiment on Holothuria atra provided evidence that asexual reproduction by fission was possible to be stimulated at laboratory. The success of the experiment was determined based on the high survival of stimulated individuals that grew into intact. After being tightened, induced individuals divided into anterior- and posteriorend individuals. During regenerating into intact individuals, the body weight decreased to relatively minimum weight. Developing of new tentacles in posterior-end individuals and anal aperture in anterior-end individuals required 7-8 weeks after fission. These indicators may lead to anatomical recovery which may be a sign of feeding necessity.
PATTERNS OF RELATIVE GROWTH IN TROPICAL NERITIDS, NERITA UNDATA, BASED ON OPERCULUM ANALYSIS
Authors: Uneputty Prulley A.
Published: August 2018

Growth is one of the important events in the life history of an organism beside reproduction. The objective of the present study was to evaluate the possibility of using the operculum to determine the growth pattern of tropical neritids (Nerita undata). Shell and operculum dimension were measured using a vernier caliper to the nearest 0.01mm. The results showed that there was a relationship between operculum dimensions (length and width) and shell, and it was also shown allometric growth pattern. The study also indicated the relationship between operculum dimension and the shell parameters.
Qualidade do leite cru refrigerado e características da produção leiteira na mesorregião oeste paranaense, Brasil
Authors: Lampugnani Camila , Perin Ana Paula , Ziech Rosangela Estel , Caxias  Júnior Osiris Antunes de , Montanhini Maike Taís Maziero , Bersot Luciano Dos Santos
Published: August 2018

O presente trabalho objetivou avaliar o perfil tecnológico e a qualidade do leite cru refrigerado produzido na mesorregião oeste paranaense, região sul do Brasil, bem como a adequação do produtoaos padrões de qualidaderequeridos pela legislação brasileira. O estudo consistiu na avaliação de 50 unidades produtoras de leite;as amostras de leite cru foram coletadas a partir do tanque de refrigeração e foram realizadas análises decontagem bacteriana total (CBT), contagem de bactérias psicrotróficas (CBP) e contagem de células somáticas (CCS).Aos produtores, foi aplicado um questionário referente ao sistema e manejo de ordenha, sistema de refrigerador, conhecimento técnico dos funcionários e informações sobre o transporte do leite à indústria de processamento. A CCSestava acima do limite legal em 47,5% das amostras avaliadas, com contagem média de 9,8x105 UFC/mL; 46% das amostras estavam igualmente acima dos limites máximos previstos para CBT. O sistema de ordenha mais comumente encontrado(em 50% das unidades produtoras) foi o de ordenha mecânica tipo“balde ao pé” e o modelo de tanque de refrigeração prevalente foi o de expansão (em 70% das unidades). A ordenha manual apresentou os melhores resultados de CBP (p<0,05), comparativamente aos demais sistemas de ordenha, emelhorCBT (p<0,05), comparado à ordenha “balde ao pé”.Os resultados obtidos evidenciam que a maioria das unidades produtoras de leite cru presentes na mesorregião deste estudo não se enquadra aos padrões de qualidade preconizados pela legislação vigente, sugerindo a necessidade de esforços e comprometimento de todos os envolvidos no setor para a obtenção de um produto de qualidade.
Obtenção de Petit Suisse com baixo teor de lactose e adição reduzida de açúcares
Authors: Renhe Isis Rodrigues Toledo , Francisquini Júlia D’Almeida , Pereira Danielle Braga Chelini , Stephani Rodrigo , Carvalho Antônio Fernandes de , Perrone Ítalo Tuler
Published: August 2018

Considerando-se as atuais tendências de mercado e orientações do governo brasileiro para a diminuição dos teores de açúcar nos produtos industrializados, faz-se necessária a adaptação das tradicionais tecnologias por outras que permitam modificações nos produtos que atendam à nova realidade sem, contudo, perder em qualidade. O desenvolvimento do presente trabalho teve como objetivo atender ao crescente público que procura por produtos com baixo teor de lactose, em função do crescimento do número de pessoas intolerantes. Associada a essa diminuição da lactose, esperava-se reduzir a quantidade de sacarose adicionada. Os resultados mostraram que a redução proposta de 20% na adição de açúcar não foi suplantada pela hidrólise da lactose e os produtos foram sensorialmente diferentes. Os produtos também apresentaram valores estatisticamente diferentes para EST, açúcares redutores, açúcares não redutores e acidez. Apesar das diferenças, os resultados indicam que esse é um produto com potencial e que se pode chegar a um produto mais próximo do original com pequenas alterações na tecnologia de obtenção.
Inferior petrosal sinus sampling in differential diagnosis of ACTH-dependent hypercortisolism
Authors: Sitkin Ivan I. , Malygina Anastasia A. , Belaya Zhanna E. , Rozhinskaya Lyudmila Y. , Buryakina Svetlana A.
Published: August 2018

Survival rate of patients with endogenous hypercortisolism, as well as complications reversibility and treatment effectiveness depends on on-time and precise diagnosis. In case of apparent clinical picture with all laboratory tests confirmation, the most challenging appears the differential diagnosis of ACTH-dependent hypercortisolism as none laboratory test can reveal the genesis of ACTH hypersecretion. When there is no visualization of the pituitary adenoma, the only method to confirm the diagnosis is bilateral inferior petrosal sinus sampling (BIPSS). Nevertheless, around 16% of patients have inactive pituitary incidentalomas in combination with carcinoid tumor of other localization. Epidemiologic researches show that the size of such incidentalomas tend to be less than 6 mm. According to clinical guidelines in case of such small neoplasms it’s recommended to perform bilateral inferior petrosal sinus sampling. This clinical case represent a rare exception to the rules when there is a pituitary adenoma more than 6 mm and mild hypercortisolism, possibly as the result of lung carcinoid tumor.
Pemodelan dan Analisis Perilaku Balok Beton Bertulang yang Berbeda Diameter Akibat Variasi Tata Letak Tulangannya
Authors: Suku Yohanes Laka
Published: August 2018

Analysis of the effect of the layout of reinforcement in reinforced concrete beams with different diameters to understand behavior and layout position of reinforcement produces the maximum of load capacity and ductility. Modeling and analysis using ANSYS program, the experimental test beam type OA1 and A1 from the University of Toronto (Vichio & Shim, 2004) was used as a benchmark and models which varies in layout of reinforcement. The number of models analyzed is a total of fourteen models consisting of seven models without stirrups and seven with stirrups. Beam behavior observed in the form of load capacity, deflection, ductility, stiffness and crack patterns. Results showed that: the layout of reinforcement affects the behavior of reinforced concrete beam; on the same width of reinforcedment, one layer reinforcement has greater load capacity and rigidity but smaller ductility than two layers; the layout of reinforcement in general does not affect the pattern of cracks; the collapse of the beam without stirrups is caused by the diagonal tension and  the beam with stirrups by shear and rupture due to the press; the layout of reinforcement produces the largest load capacity and ductility of the largest is model OA1 and OA1,4 on the beams without stirrups and models A1 and A1,5 on beam with stirrups.
Analisis Ketahanan Gempa Rumah Tembokan Beton Bertulang di Perumahan Graha Arradea
Authors: Yoresta Fengky Satria
Published: August 2018

The concept of earthquake resistant houses is basically that all building components must be well tied each other. In addition, quality of materials and workmanship must also be good so as to produce a strong building when receiving shocks. This study aims to determine whether houses in Perumahan Graha Arradea (Tahap 3 in Ciherang Village, Dramaga Subdistrict, Bogor District - West Java are built following the design principles of earthquake  resistant houses. The research is conducted by observing the construction process at the location. Every stage of the construction process is recorded using a digital camera (Sony Cyber-shot DSC-W730). Interviews are also conducted on related parties to obtain accurate informations. The results conclude that the houses that are built have not met minimum requirements for design of earthquake resistant masonry houses with reinforced concrete frame. In addition to quality of some materials that have not met minimum requirements, the quality of workmanship of building component is also still low. The ties of all building components have not been properly connected.
Evaluasi Kinerja Campuran Beraspal dengan Bitumen Hasil Ekstraksi Penuh dari Asbuton
Authors: Suaryana Nyoman , Susanto Iwan , Ronny Yohannes , Sembayang Ida Rumkita
Published: August 2018

Asbuton is a natural rock asphalt that can be found on the island of Buton in Southeast Sulawesi province, has a large deposits but not yet well utilized. This research aims to find out the performance of asphalt mixtures AC-WC (Asphaltic Concrete Wearing Course) and HRS-WC (Hot Rolled Sheet Wearing Course) using bitumen results from full extraction of asbuton. The research was done by experimental methods through laboratory tests then its performance was compared to convensional mixtures using asphalt oil with penetration grade of 60. The results obtained showed that the bitumen of asbuton did not meet the specification of bitumen based on penetration grade. Characteristics of hot mixture asphalt using bitumen of asbuton showed better performance in terms of the Marshall stability namely 1871 kg higher than the convensional hotmixture of asphalt, with 1100 kg for AC-WC and 1241.9 kg compared with 1094 kg for HRS-WC. In addition, the results of deformation resistance tests showed asphalt mix with pure asbuton  more resistant to rutting shown by higher dynamic stability value namely 4200 track/mm compared with 492 track/mm for AC-WC and 2739 track/mm compared with 325 track/mm. The modulus resilient value of mix with pure asbuton is also higher at temperature of 25°C and relatively the sameat temperatures of 35°C and 45°C. While the resistance of  fatigue for AC-WC and HRS-WC on the test tensile strain of 150 µs were relatively the same as hotmix asphalt using asphalt oil penetration grade of 60, but on test of  a larger tensile strain has worse fatigue resistance, especially for AC-WC.
Faktor yang Mempengaruhi Keberhasilan Penerapan Teknologi Bidang Jalan dengan Kontrak Rancang Bangun
Authors: Hendrawan Hendra
Published: August 2018

Research and development in the roads sector is one of the coaching tasks of roads authority. To disseminate the results of research or technology that has been developed required the transfer of technology which one of them through technology implementation project. In the Year 2015-2017 Institute of Road Engineering has carried out the technology transfer process through limited project of implementation technology  by using Design and Build contract. In the implementation project there are some constraints or factors that affect the implementation performance so that the resulting output is not optimal. The purpose of the study is to identify the critical determinants of project success of technology implementation with Design and Build contract and to give weighting. The method used in the study is descriptive qualitative analysis using data collection tools in the form of interviews and questionnaires to further analyzed by Analytical Hierarchy Process method. The results of the study showed that the factors that affect the successful of implementation technology projects is qualification of providers. The sub aspect that is considered has big influence is the financial ability for the qualification aspect, and the basic knowledge to the technology developed for technical aspect.
PENGARUH FLUKTUASI INDUSTRIALISASI TERHADAP KAPABILITAS MASYARAKAT PEDESAAN DI MAGELANG: PERSPEKTIF PERENCANAAN WILAYAH
Authors: Pramono Retno Widodo Dwi
Published: August 2018

Industrialisasi sebagai pemicu transformasi struktur ekonomi, sangat penting bagi proses perkembangan wilayah. Namun, industrialisasi dapat mengalami fluktuasi. Wilayah yang bergantung pada investasi luar, sering mengalami de-industrialisasi akibat migrasi industri ke wilayah yang dianggap lebih menguntungkan, misalnya karena tenaga kerja yang lebih murah dan pasar yang sedang berkembang. Bagaimana akibat perkembangan industrialisasi dan de-industrialisasi pada masyarakat lokal yang agraris? Tulisan ini bertujuan untuk menjawab pertanyaan tersebut dari perspektif perencanaan wilayah. Dengan mengambil kasus pada 2 kecamatan di Magelang dan berdasarkan data series  dari tahun 1970-an hingga 2010 serta  observasi investigatif secara langsung ke masyarakat, penelitian mengungkap akibat positif dan negatif dari perkembangan industri di wilayah ini, dan sisi positif maupun negatif dari fase de-industrialisasi. Pada masa perkembangan industri, hal yang paling positif adalah meningkatnya rasio lahan per petani yang memberi peluang bagi unit usaha petani untuk meningkatkan skala ekonominya melalui sewa-menyewa lahan. Temuan lain yang menarik adalah de-industrialisasi Industri skala menengah dan besar yang investasinya dari luar, memicu re-industrialisasi oleh masyarakat lokal dalam bentuk pertumbuhan industri rumah tangga. Dari tulisan ini, dalam melakukan tugasnya, perencana wilayah harus mengantisipasi dinamika seperti arahan alokasi penggunaan lahan serta manajemen pemanfaatanya.
PENGEMBANGAN FUNGSI KAWASAN RTH WADUK BATUJAI SEBAGAI RUANG PUBLIK DI KOTA PRAYA, KABUPATEN LOMBOK TENGAH, NTB
Authors: Saputra Iqbal Prayadi
Published: August 2018

Kawasan RTH waduk Batujai yang berperan sebagai ruang publik perkotaan Praya Kabupaten Lombok Tengah saat ini belum berfungsi dengan baik terhadap meningkatnya perkembangan kota. Meningkatnya pemanfaatan dan aktivitas di kawasan RTH sebagai tempat rekreasi, bermain, maupun olahraga tidak diikuti dengan peningkatan kualitas lingkungan serta penyediaan fasilitas penunjang yang memadai. Permasalahan lainnya adalah belum dikembangkannya kawasan RTH waduk Batujai ini secara optimal, sehingga diperlukan suatu kajian arahan pengembangan kawasan RTH waduk Batujai sebagai ruang publik. Penelitian ini menggunakan pendekatan kuantitatif dengan metode penelitian survei melalui kuesioner terhadap 175 responden yang terdiri masyarakat setempat dan pengunjung RTH serta 100 wisatawan, dengan teknik simple random sampling. Teknik analisis menggunakan deskriptif kuantitatif dengan model gravitasi, distribusi frekuensi dan SWOT. Hasil penelitian menunjukkan bahwa pengembangan kawasan RTH Batujai berada pada posisi Stable growth strategy dengan arahan pengembangan; Dikembangkan sebagai rekreasi Taman Kota (urban park) dan hutan kota serta pengembangan rekreasi olahraga air; Peningkatan kuantitas dan kualitas fasilitas wisata; meningkatkan potensi daya tarik dan menambah atraksi wisata; meningkatkan kualitas aksesibilitas; penataan vegetasi; pelestarian perairan waduk, serta penataan area sempadan waduk dan sungai sekitar.