bluuebunny/crossref_metadata_2025 huggingface dataset:
Outcomes of living‐donor liver transplantation for acute‐on‐chronic liver failure based on newly proposed criteria in Japan
Authors: Toshima Takeo , Harada Noboru , Itoh Shinji , Morita Kazutoyo , Nagao Yoshihiro , Kurihara Takeshi , Tomino Takahiro , Kosai‐Fujimoto Yukiko , Morinaga Akinari , Tomiyama Takahiro , Yoshizumi Tomoharu
Published: June 2022

Aim

Recently, new diagnostic criteria for acute‐on‐chronic liver failure (ACLF) were established in Japan. However, there is little evidence regarding the feasibility of classifying patients undergoing living‐donor liver transplantation (LDLT). The aim was to re‐evaluate the impact of these new diagnostic criteria on ACLF and the severity classification of patients undergoing LDLT.

Methods

We collected data of 82 recipients who underwent LDLT for liver failure between 1997 and 2020 and reviewed it retrospectively.

Results

Of the 82 patients with liver failure, 31 (37.8%) were diagnosed with ACLF; Grade 0 (n = 6), Grade 1 (n = 7), Grade 2 (n = 9), and Grade 3 (n = 9). There was no substantial difference in overall survival (OS) and the occurrence of postoperative complications between liver failure patients with and without ACLF. The OS after LDLT was significantly different among the four groups of ACLF patients (P = .036). Interestingly, ACLF Grade 3 patients had substantially lower OS compared to other ACLF groups even after LDLT (P = .006; 5‐year OS rates, 33.3% vs. 85.9%).

Conclusion

Proper use of the new diagnostic criteria for ACLF in Japan demonstrated that the presence and severity of ACLF, especially the presence of multiple organ failures, leads to morbidity and mortality even in an LDLT setting. Considering that the patients with ACLF Grade 3 do not have the favorable outcomes of LDLT, deceased‐donor liver transplantation usage, or LDLT before reaching the severity of Grade 3 may be suitable for further research.
Safety, pharmacokinetics and target engagement of novel RIPK1 inhibitor SAR443060 (DNL747) for neurodegenerative disorders: Randomized, placebo‐controlled, double‐blind phase I/Ib studies in healthy subjects and patients
Authors: Vissers Maurits F. J. M. , Heuberger Jules A. A. C. , Groeneveld Geert Jan , Oude Nijhuis Jerome , De Deyn Peter Paul , Hadi Salah , Harris Jeffrey , Tsai Richard M. , Cruz‐Herranz Andres , Huang Fen , Tong Vincent , Erickson Rebecca , Zhu Yuda , Scearce‐Levie Kimberly , Hsiao‐Nakamoto Jennifer , Tang Xinyan , Chang Megan , Fox Brian M. , Estrada Anthony A. , Pomponio Robert J. , Alonso‐Alonso Miguel , Zilberstein Moshe , Atassi Nazem , Troyer Matthew D. , Ho Carole
Published: June 2022

RIPK1 is a master regulator of inflammatory signaling and cell death and increased RIPK1 activity is observed in human diseases, including Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). RIPK1 inhibition has been shown to protect against cell death in a range of preclinical cellular and animal models of diseases. SAR443060 (previously DNL747) is a selective, orally bioavailable, central nervous system (CNS)–penetrant, small‐molecule, reversible inhibitor of RIPK1. In three early‐stage clinical trials in healthy subjects and patients with AD or ALS (NCT03757325 and NCT03757351), SAR443060 distributed into the cerebrospinal fluid (CSF) after oral administration and demonstrated robust peripheral target engagement as measured by a reduction in phosphorylation of RIPK1 at serine 166 (pRIPK1) in human peripheral blood mononuclear cells compared to baseline. RIPK1 inhibition was generally safe and well‐tolerated in healthy volunteers and patients with AD or ALS. Taken together, the distribution into the CSF after oral administration, the peripheral proof‐of‐mechanism, and the safety profile of RIPK1 inhibition to date, suggest that therapeutic modulation of RIPK1 in the CNS is possible, conferring potential therapeutic promise for AD and ALS, as well as other neurodegenerative conditions. However, SAR443060 development was discontinued due to long‐term nonclinical toxicology findings, although these nonclinical toxicology signals were not observed in the short duration dosing in any of the three early‐stage clinical trials. The dose‐limiting toxicities observed for SAR443060 preclinically have not been reported for other RIPK1‐inhibitors, suggesting that these toxicities are compound‐specific (related to SAR443060) rather than RIPK1 pathway‐specific.
Is conferralism descriptively adequate?
Authors: Alcoff Linda Martín
Published: June 2022

This paper will develop a set of concerns about a central feature of Ásta's account of social categories that she calls “conferralism.” I argue that generalist approaches to social categories such as Ásta provides are inadequate as a way of understanding the diverse formations of diverse categories, and that conferralism overemphasizes the power of top‐down forces (what she calls “persons with standing”) to confer social identities. This approach then underplays the horizontal and bottom‐up influences on category formation as well as the historical formation of many social identities, especially ethnicity and race. Conferralism sets aside not only physical differences that play a role in some categories but also group‐related historical experiences and practices that produce the “base properties” that justify the use of social identity categories.
Reducing the dependency of having prior domain knowledge for effective online information retrieval
Authors: Zammit Omar , Smith Serengul , Windridge David , De Raffaele Clifford
Published: June 2022

Sometimes Internet users struggle to find what they are looking for on the Internet due to information overload. Search engines intend to identify documents related to a given keyphrase on the Internet and provide suggestions. Having some background knowledge about a topic or a domain will help in building effective search keyphrases that will lead to accurate results in information retrieval. This is further pronounced among students that rely on the internet to learn about a new topic. Students might not have the required background knowledge to build effective keyphrases and find what they are looking for. In this research, we are addressing this problem, and aim to help students find relevant information online. This research furthers existing literature by enhancing information retrieval frameworks through keyphrase assignment, aiming to expose students to new terminologies, therefore reducing the dependency of having background knowledge about the domain under study. We evaluated this framework and identified how it can be enhanced to suggest more effective search keyphrases. Our proposed suggestion is to introduce a keyphrase Ranking Mechanism that will improve the keyphrase assignment part of the framework by taking into consideration the part‐of‐speech of the generated keyphrases. To evaluate the proposed approach, various data sets were downloaded and processed. The results obtained showed that our proposed approach produces more effective keyphrases than the existing framework.
Political ecologies of resettlement in river deltas
Authors: Neu Friedrich Nikolaus , Fünfgeld Hartmut
Published: June 2022

In river deltas, human interference with regional and global socio‐ecological systems has led to a plethora of gradual and more abrupt environmental changes that result in inundation, coastal and river bank erosion, land loss and, ultimately, displaced people. Often apolitically framed as protective, state‐led transfer of people to new housing grounds,resettlementhas become a common response to such displacements. In its process, existing arrangements of land tenure and occupancy and, at times more covertly, related arrangements of capital, labor and the social fabric become dislocated and reassembled. In line with emerging critical geographies of resettlement, this paper conceptualizes resettlement in river deltas against the background of environmental change as a highly political process with far‐reaching environmental, economic, social and cultural implications. For this article is based on an in‐depth review of both resettlement and political ecology literature, we first elucidate the concept of resettlement before providing a structured overview of categories and recent trends in resettlement literature. We then focus on river deltas that due to multi‐scale environmental change are about to become hotspots of future resettlement. Building on identified gaps in resettlement literature, the article concludes with opening up three analytical strands of political ecology as entry points to resettlement studies, understood as critical geographic research into localized manifestations of environmental change in river deltas. Overall, our paper aims to initialize conceptual debate, grounded in a thorough review of recent case study literature on resettlement that is informed by political ecology. The review challenges positivist reductions of resettlement processes as technocratic‐managerial tasks that so far have dominated scientific literature in this field and opens up new perspectives for critical research on resettlements in river deltas for human geographers.
Illegalities in the online trade of stingless bees in Brazil
Authors: Carvalho Antônio F.
Published: June 2022

Stingless bees are commercialised in Brazil through the internet. Such trade has mixed populations and introduced species, allows the potential dissemination of hitchhiker symbionts and diseases, and mostly does not follow national legislation policies.

At least 33 species of stingless bees have been exploited by e‐commerce; eight others were not confirmed. All transactions found are in the surface web and most sellers do not fulfil legal requirements. Such results suggest that there is little need of anonymity for sellers, a fact that strengthens conclusions on the recurrently reported lack of successful law enforcement against illegal wildlife trade in the country.

Critical geographical zones in Brazil, where sellers of stingless beehives are concentrated, are primarily in the Atlantic Forest. Urgent policy measures and scientific evaluations are necessary for both conservation of bees and risk control of pathogens. The most promising strategy to avoid the threats regarding movement of bees is the education of stingless bee keepers.
Assessment of executive functions and physical activity in girls and boys with normal weight, overweight and obesity
Authors: Patraca‐Camacho Lorena , Cibrián‐Llanderal Tamara , Acosta‐Mesa Héctor‐Gabriel , Rodríguez‐Landa Juan Francisco , Romo‐González Tania , Rosas‐Nexticapa Marcela , Herrera‐Meza Socorro
Published: June 2022

Objective

To evaluate the association between body mass index (BMI) and performance of executive functions (EFs) in girls and boys with 9‐ and 10‐year‐old schoolchildren with moderate‐ to vigorous‐intensity physical activity (MVPA) and sedentary behaviour.

Methods

A total of 120 schoolchildren (61 girls and 59 boys) were evaluated anthropometrically. The MVPA was evaluated with a self‐report questionnaire. EFs were measured using a neuropsychological battery of Executive Functions and Frontal Lobes‐2 (BANFE‐2).

Results

A high BMI was associated with longer delay in completing inhibitory control tests (p = 0.00, rp = 0.32) and working memory (p = 0.00, rp = 0.26). We observed correlations in time (p = 0.00, rp = −0.43) and hits (p = 0.04, rp = −0.27) of self‐directed signalling test in boys; and girls in alphabetical words order (p = 0.00, rp = −0.39). Active normal weight schoolchildren (ANw) performed better by successfully completed the working memory tasks (H = 26.97, p = 0.00) than sedentary schoolchildren with overweight and obesity. In addition, overweight‐active schoolchildren (AOw) showed better performance on working memory tests in time (p = 0.00) and hits (p = 0.01) than their sedentary peers. Multiple linear regression analysis revealed a significant association between BMI and EFs scores (F = 2.41, df = 98, p = 0.001).

Conclusions

EFs are affected by a high BMI and sedentary behaviour in school children. Boys and girls reflected differences to solve the same challenges. The MVPA has a positive effect on executive control skills mainly in overweight children.
Supervising Art and Design Students Who Integrate Mental Health Experiences with Autobiographical Research
Authors: Ings Welby
Published: June 2022

This article discusses some implications of working supportively with art and design students who manage mental health conditions in a postgraduate environment in a New Zealand University. The paper begins with a discussion of contesting research that considers relationships between highly creative thinkers and certain mental health conditions. It then proposes that, irrespective of arguments around correlations, supervisors are able to make a significant contribution to supporting candidates who combine autobiographically sourced knowledge with artistic inquiries into the experience of living with a mental health condition. In considering this proposition, the paper employs two case studies that illustrate certain strategies that proved useful when seeking to maximise the chances of successful and productive thesis completions. Working in tandem with wider institutional and therapeutic support, these strategies functioned alongside each candidate's research journey. Eight of these approaches are discussed in relation to a pedagogically responsive, informed and creatively supportive environment in which the students were able to develop complex and insightful research projects.
Serum leucine‐rich alpha‐2 glycoprotein as a predictive factor of endoscopic remission in Crohn's disease
Authors: Abe Izuru , Shiga Hisashi , Chiba Hirofumi , Miyazawa Teruko , Oomori Shinya , Shimoyama Yusuke , Moroi Rintaro , Kuroha Masatake , Kakuta Yoichi , Kinouchi Yoshitaka , Masamune Atsushi
Published: June 2022

Background and Aim

The usefulness of fecal calprotectin (FC) and serum leucine‐rich alpha‐2 glycoprotein (LRG) assessing the activity of Crohn's disease (CD) remains to be fully demonstrated in Asia. The present study aimed to elucidate whether FC and LRG could predict endoscopic remission (ER) in Japanese patients with CD.

Methods

Between October 2018 and July 2021, we prospectively observed treatment courses of CD patients treated with biologic agents. The optimal cutoff values of Crohn's Disease Activity Index (CDAI), serum C‐reactive protein (CRP), serum albumin (Alb), FC, and LRG levels for predicting ER at week 52 were calculated using receiver operating characteristic (ROC) curves. We also analyzed the correlations between the achievement of clinical remission (CR) or biomarker remission (BR) at week 12/24/52 and ER at week 52.

Results

Among 53 patients who completed 52 weeks of observation, 20 (37.7%) achieved ER at week 52. Using the calculated cutoff values, patients who achieved CR (CDAI ≤ 112) or BR (CRP ≤ 0.42 mg/dL, Alb ≥ 3.8 g/dL, FC ≤ 287 μg/g, or LRG ≤ 13.6 μg/mL) at week 12/24/52 had a higher ER rate at week 52. FC‐BR at week 12/24 showed low sensitivity (0.58/0.60) but high specificity (0.78/0.74) for predicting ER; LRG‐BR at week 12/24 also showed low sensitivity (0.68/0.74) but high specificity (0.87/0.78). However, FC‐BR and LRG‐BR at week 52 had improved sensitivity (0.80/0.84) while specificity remained (0.79/0.85).

Conclusions

From the early phase of biologic treatment, both FC and LRG had high specificity for predicting ER at week 52. LRG showed higher sensitivity than FC.
Effects of 24‐week basketball programme on body composition and functional fitness on adults with Down syndrome
Authors: Cai W. , Baek S.‐S.
Published: June 2022

Background

The body index [body mass, body mass index (BMI), waist circumference and waist–height ratio] and functional fitness (aerobic capacity, muscular strength, balance, flexibility and functional ability) of people with Down syndrome (DS) are substantially lower than those in the general population, as DS has an overall negative impact on health.

Aims

This study explored the effect of a 24‐week basketball training programme on the body composition and functional fitness of adults with DS.

Methods and procedure outcomes

Twenty‐two adults with DS (24 ± 6 years; 25 ± 4 kg/m2) were randomly allocated to the experimental (n = 11, 67.04 kg) and control groups (n = 11, 69.36 kg). The experimental group performed 24 weeks of basketball programme training (3 times per week, 60 min per session), while the control group maintained their daily activities without any special physical training. Body composition and functional fitness parameters were measured before and after the intervention. To evaluate the differences between groups, an analysis of covariance (ANCOVA) was used while controlling for differences at baseline.

Results

Hip circumference and waist–height ratio were statistically different at baseline between the intervention and control groups. After the 24‐week basketball training programme, the results showed significant differences between the exercise and control groups for hip circumference, body mass, BMI, waist circumference, hip circumference, waist–height ratio, flexibility, aerobic capacity, static and dynamic balance, balance and basketball functional ability (P < 0.05). The exercise group showed significant improvements in all variables of body composition and functional fitness (P < 0.05) except for the waist–hip ratio. There was no statistical significance between all physical composition and functional health variables in the control group except for the standing long jump (P > 0.05), with effect sizes ranging from small to large.

Conclusions and implications

The basketball training programme improved body composition and functional fitness of adults with DS.
No innovation without entrepreneurship: From passion to practice
Authors: Hölzle Katharina
Published: June 2022

In his Catalyst article, Kenneth Kahn takes an institutional perspective on innovation and entrepreneurship, arguing that a lack of differentiation between these two terms results in a missing demarcation of entrepreneurship and innovation centers at universities. This leads to research and teaching activities in the respective areas that are not clearly differentiated and therefore create suboptimal results. I reflect on Kenneth's thoughts but argue that we should not aim for two different centers or estranged disciplines of entrepreneurship and innovation but rather take a joint perspective centering on the challenges of creating and bringing the new to the world. I call for a joint core (aka the entrepreneurial mindset) of entrepreneurship and innovation at universities but different curricula and instruments for the individual challenges of entrepreneurship and innovation, differentiating along the source of the problem or idea, the disciplines involved, the instruments and conditions needed, and the ecosystems to be built.
Trajectory, recovery, and orbital history of the Madura Cave meteorite
Authors: Devillepoix Hadrien A. R. , Sansom Eleanor K. , Shober Patrick , Anderson Seamus L. , Towner Martin C. , Lagain Anthony , Cupák Martin , Bland Philip A. , Howie Robert M. , Jansen‐Sturgeon Trent , Hartig Benjamin A. D. , Sokolowski Marcin , Benedix Gretchen , Forman Lucy
Published: June 2022

On June 19, 2020 at 20:05:07 UTC, a fireball lasting was observed above Western Australia by three Desert Fireball Network observatories. The meteoroid entered the atmosphere with a speed of  km  and followed a ° slope trajectory from a height of 75 km down to 18.6 km. Despite the poor angle of triangulated planes between observatories (29°) and the large distance from the observatories, a well‐constrained kilo‐size main mass was predicted to have fallen just south of Madura in Western Australia. However, the search area was predicted to be large due to the trajectory uncertainties. Fortunately, the rock was rapidly recovered along the access track during a reconnaissance trip. The 1.072 kg meteorite called Madura Cave was classified as an L5 ordinary chondrite. The calculated orbit is of Aten type (mostly contained within the Earth’s orbit), only the second time a meteorite was observed on such an orbit, after Bunburra Rockhole. Dynamical modeling shows that Madura Cave has been in near‐Earth space for a very long time. The dynamical lifetime in near‐Earth space for the progenitor meteoroid is predicted to be ~87 Myr. This peculiar orbit also points to a delivery from the main asteroid belt via the resonance, and therefore an origin in the inner belt. This result contributes to drawing a picture for the existence of a present‐day L chondrite parent body in the inner belt.
Delimiting Legal Interpretation: The Problem of Moral Bias and Political Distortion—the Case of Criminal Intention
Authors: Skoczeń Izabela , Poggi Francesca
Published: June 2022

This essay criticizes Dworkin’s and Greenberg’s interpretivism using one concrete example, namely, the interpretation of rules of criminal law pertaining to intentionality ascriptions. In fact, according to interpretivism, some judicial interpretations of criminal intention can be explained as practices that depart from legislatively communicated content to implement moral principles. We distinguish between a Kantian and a consequentialist approach to criminal intention and claim that judicial practice can be viewed as an implementation of the consequentialist approach which pulls apart the Kantian criteria communicated by the legislator. However, we argue that, in doing so, judges open the door to folk biases, political pressures, and stereotypes that produce distorted and unfair results. To deal with this objection, interpretivism would have to both claim that judicial practice is erroneous and provide a theory of objective moral truth, yet it fails in both respects.
Asymptotics of solutions to periodic problem for the Korteweg–de Vries–Burgers equation
Authors: Naumkin Pavel I. , Villela‐Aguilar José de Jesús
Published: June 2022

We consider the periodic problem for the Korteweg–de Vries–Burgers (KdVB) equation with pumping
where , . We study the solutions, which satisfy the periodic boundary conditions for all and , with the 2π—periodic initial data . Our aim is to find large time asymptotic profile of solutions. The large time asymptotic behavior of solutions to the Cauchy problem for the KdVB equations with different dissipative terms was extensively studied. In the present paper we find the asymptotic profile of solutions for large time. We develop the approach started in Refs. [1, 2, 3]. We prove the following asymptotics for the solutions:
as uniformly with respect to , where , , , , , Λ is a constant.
Representations of dementia and their role in social expectations regarding ageing
Authors: Marhánková Jaroslava Hasmanová
Published: June 2022

This paper reviews existing research on dementia worry and its role in general fears and expectations regarding one's ageing. Understanding older people's knowledge regarding dementia, the way they construct meanings regarding dementia and older age, and their attitudes toward people already experiencing dementia is essential in formulating adequate social and health policy, as well as for our understanding of the experience of ageing (with, without or in addition to dementia). This paper explores dementia as a significant framework for the construction of anxieties regarding advanced old age and also a symbolic reference point for the representations of the third and fourth ages — successful and less successful ageing. We point out a crucial role on the part of dementia in the social images of ageing, not only as a symbolic embodiment of frailty but also as an essential framework through which the distinction between desirable “successful”, “active” ageing, and “failed”, “horrific” old age is (re)constructed.
Discovery of the novel HLA‐B*13:173 allele in a Taiwanese individual
Authors: Yang Kuo‐Liang , Li Chi‐Cheng , Lin Py‐Yu
Published: June 2022

A nucleotide mutation in exon 1 of HLA‐B*13:01:01:01 results in the novel allele HLA‐B*13:173.
Retrospective evaluation of pre‐surgical electroretinography results in a mixed‐breed canine population presented for cataract removal surgery
Authors: Wegg Michaela L. , Pollard Danica , Ofri Ron
Published: June 2022

Objective

Electroretinography (ERG) is used prior to cataract removal surgery to assess retinal function. We aimed to replicate and improve upon previous studies by performing a full ECVO protocol and by examining the retina post‐surgery in all patients.

Animals studied

One hundred twenty‐seven eyes from 67 dogs were included in the study.

Procedures

A full ECVO protocol electroretinography, which includes extensive rod and cone analysis, was performed on all dogs presenting for cataract surgery.

Results

Our main findings were that amplitudes, but not implicit times of rod responses decreased with advanced cataracts. Amplitudes of the single flash rod and rod flicker responses were significantly lower in eyes with mature cataracts, and the former also decreased in hypermature cataracts. Cone flicker amplitude responses were also significantly lower in eyes with mature and hypermature cataracts. However, mixed single flash rod‐cone and cone responses, with the exception of the mixed rod‐cone a‐wave amplitude in eyes with hypermature cataracts, were unaffected by cataract stage. The b‐wave amplitude of the scotopic, mixed rod‐cone, and photopic cone responses were affected by age and decreased by an average of 2.9, 7.5, and 1.5 μV/year, retrospectively (p < 0.01).

Conclusions

Lower ERG amplitudes in canine cataract patients may result from aging or the presence of advanced cataracts and may not indicate the presence of retinal disease.
Comparison of single strain, natural algal communities and a native algal bloom: Application for wastewater treatment and biomass generation in cassava biogas effluent
Authors: Padri Mohamad , Boontian Nittaya , Piasai Chatlada
Published: June 2022

Phycoremediation of Chlorella sorokiniana P21 as indigenous strain (P21), four algal communities from different wastewater treatment ponds (P1, P2, P3 and P4) and a native algal bloom (CTRL) were examined to treat cassava biogas effluent wastewater (CBEW) and generate algal biomass. All cultures showed higher biomass production in unsterilized CBEW than in the sterilized CBEW, whereas nutrient removal efficiency was not significantly different in both conditions for all cultures. Verhulst kinetics models showed P21 culture has the highest maximum biomass (1440.94 mg L−1), whereas P3 showed the highest growth rate (0.68 day−1). The removal efficiencies of these cultures for nitrate, phosphate and chemical oxygen demand were above 75%. Iron coagulants attained the removal to be more than 90% only in P21 culture. Indigenous and algal community cultures had similar potencies to treat wastewater, and thus, this result showed vast potency of phycoremediation using various inoculum sources.
Prediction of sludge settleability through artificial neural networks with optimized input variables
Authors: Zheng Yue , Peng Zhaoxu , Xia Houbing , Zhang Wangcheng
Published: June 2022

Sludge bulking is a major problem in activated sludge processes. It is of great practically useful to predict the sludge settleability through water quality (influent and effluent) and the operation patterns. In this study, the artificial neural network (ANN) to predict the variation of sludge settleability was established with MLSS, organic loading rate and NH4+‐N loading rate as basic input variables. Additional input variables were optimized through comparing the performance of multilayer perceptron artificial neural network (MLPANN) with different combinations. The results showed that excellent nitrification will improve sludge settleability, and the famine phase would promote the growth of filamentous bacteria. Furthermore, the model performance of MLPANN and long short‐term memory networks (LSTM) were compared by using optimized input variables. The results indicated the MLPANN performed better than LSTM with optimized inputs. This study provided a reference of optimizing variables to predict the variation of sludge settleability in activated sludge process. This study will provide a reference for selecting appropriate variables to predict sludge settleability in activated sludge processes.
Preparation of porous biomass‐based sponge with zein‐alginate for oil absorption
Authors: Liu Xiaoqing , Huang Peng , Wang Jianfeng , He Yufeng , Song Pengfei , Wang Rongmin
Published: June 2022

In order to effectively promote the treatment of pollution containing organics or crude oil, many oil‐absorbing materials were explored. However, most of them were synthetic polymers, which was difficult to be decomposed and easily cause secondary pollution. In this study, zein and sodium alginate (SA), two cheap natural polymer materials, were used as eco‐friendly and biodegradable biomass materials; a novel porous biomass‐based sponge (ZS‐PBSp) was synthesized. Then, by impregnating with SiO2 nanoparticle (nano‐SiO2) and octadecanethiol (OCT), the modified porous sponge (ZSSiOsp) was obtained. ZSSiOsp was characterized by scanning electron microscopy (SEM), infrared (IR), X‐ray diffraction (XRD) and thermogravimetric analysis (TGA) and applied to adsorb organics, such as organic solvents, petroleum products and cooking oil. It indicated that the surface of ZSSiOsp was rough, and its water contact angle (WCA) increased to 131.5°. ZSSiOsp effectively adsorbed organics, its absorption capacity got to 115.7% for chloroform and 77.6% for rapeseed oil, respectively. It also effectively separated oily substances from oil–water mixture. In summary, the obtained ZSSiOsp was an eco‐friendly material for oil absorption and separation, which was a kind of promising candidate in water treatment and environmental protection.
Promoting wastewater treatment in India: Critical questions of economic viability
Authors: Bassi Nitin , Kumar Saurabh , Kumar M. Dinesh , Van Ermen Sofie , Campling Paul
Published: June 2022

The article shows that while there is rich literature on the cost‐effectiveness of wastewater treatment systems, little analysis exists on their economic viability that goes beyond direct benefits and costs to include externalities, which is very crucial for developing countries like India. This article first presents the results of life cycle cost assessment of various wastewater treatment technologies used in India. The article then shows that the direct benefits from treated wastewater are unlikely to be high in most situations due to lack of orientation towards the demand. It argues that for sustainable investments in wastewater treatment, the indirect benefits including public health benefits due to protection of drinking water sources, environmental benefits due to maintenance of aquatic life and improvement of soil health, which are determined by the socio‐economic and ecological conditions that vary across regions, should also be considered and quantified.
Triangular Cooperation of China-Japan in ASEAN Countries: Empirical Analysis and Path Selection
Authors: Shigang Yan , Peng Yu , Meng Zhang
Published: June 2022

In the post COVID-19 Era, ASEAN countries continue to focus on alleviating the impact of the pandemic and supporting an economic recovery. The active promotion of triangular cooperation will be of great significance to the economic recovery and regional integrated development. The paper analyzed trade complementarity between China, Japan with ASEAN countries, estimated revealed comparative advantage index of China and Japan in comparison to ASEAN countries. Based on the empirical result, the paper put forward several suggestions to promote TC of China-Japan in ASEAN, which including to improve regional supply chain, strengthen financial cooperation, and promote local governments and association’s cooperation.
Reviewer Acknowledgements for International Journal of English and Cultural Studies, Vol. 5, No. 1
Authors: Howard Nina
Published: June 2022

International Journal of English and Cultural Studies (IJECS) would like to acknowledge the following reviewers for their assistance with peer review of manuscripts for this issue. Many authors, regardless of whether IJECS publishes their work, appreciate the helpful feedback provided by the reviewers. Their comments and suggestions were of great help to the authors in improving the quality of their papers. Each of the reviewers listed below returned at least one review for this issue. Reviewers for Volume 5, Number 1 Alvaro Recio, University of Salamanca, SpainEmmanuel Chibuzor Okereke, National Examinations Council, NigeriaEsther Pujolràs-Noguer, Autonomous University of Barcelona, SpainHerman, University of HKBP Nommensen, IndonesiaJelena Timotijevic, University of Brighton, United KingdomMohammed Nasser, Wasit University, IraqShashi Naidu, Ball State University, United States Nina HowardEditorial AssistantInternational Journal of English and Cultural StudiesRedfame Publishing9450 SW Gemini Dr. #99416Beaverton, OR 97006-6018, USAWebsite: http://ijecs.redfame.com
Analysis of Modified Reverse Brayton Cycle-Based Systems for Cold Generation at Low Temperature Using Exergoeconomics
Authors: Dhillon Aman Kumar , Ghosh Parthasarathi
Published: June 2022

High-temperature superconductor (HTS)-based technology is getting increased attention as the most appropriate technology for electric power transmission towards reduction in CO2 emissions and augmentation of the energy supply. However, this cryogenic technology demands highly efficient and economically reliable cooling systems, having a cooling capacity of 2–10 kW at a temperature range of 65–80 K. The refrigeration cost is one of the critical issues for such superconducting technologies to penetrate the marketplace. Thus, cryocoolers with modification based on reverse Brayton cycle (RBC) comprising different turbine arrangements are analyzed to meet the demand of cryogenic technologies. The exergoeconomic analysis which combines the exergy and economic analysis is performed to identify the source of exergy destruction that affects the economy and performance of the systems based on RBC. The optimized RBC configurations using the exergoeconomic tool are evaluated and compared to find a thermodynamically enhanced configuration with reduced refrigeration cost. These configurations are compared using exergy, economic, exergoeconomic, design evaluation parameters, and environmental footprint. The results indicate that the cost of exergy destruction reduces around 30% while optimizing these novel RBC configurations. The saving with successful running for ten years is around 6% of the total investment using parallel expansion with different pressure ratio (PED) RBC configuration, which is one of the best performances with 41.1% exergy efficiency. Based on the study, recommendations based on exergoeconomic parameters are also provided for further improvement in the cycles.
Coaching and Coach Education in Turkey: History, Status, and Future
Authors: Işık Arda Alan , Moustakas Louis
Published: June 2022

Coaching and coach education have been part of government policies in Turkey since the foundation of the Republic in 1923. Nevertheless, the current state of coaching and coach education in Turkey has been criticized due to its disjointed nature. Added to that, there has been a lack of comprehensive mapping of the different elements of coaching and coach education, which in turn inhibits evaluation and growth. Therefore, the purpose of this paper is to provide a practical historical overview of coaching and coach education in Turkey to identify strengths, weaknesses, and future directions for the overall sport coaching system. Findings for this paper are generated via an analysis of policy and academic texts, as well as interviews with two academics working directly in coach education. In the end, future recommendations established from a review of the coaching and coach education literature addressing the weaknesses in the Turkish coaching system are suggested.
Comment on “Improper molecular ferroelectrics with simultaneous ultrahigh pyroelectricity and figures of merit” by Li
et al.
Authors: Szafrański Marek , Katrusiak Andrzej
Published: June 2022

Li
et al
. (
Science Advances
, 29 January, p. eabe3068) claim the discovery of two improper ferroelectrics, dabcoHClO
4
and dabcoHBF
4
(dabco = 1,4-diazabicyclo[2.2.2]octane), and that these materials exhibit superior pyroelectric figures of merit. This information is misleading because of the fundamental methodological errors and false conclusions, not to mention that these ferroelectrics were reported more than 20 years ago. They are proper ferroelectrics, for which the spontaneous polarization is the macroscopic order parameter. We show that the useful pyroelectric coefficients of dabcoHClO
4
and dabcoHBF
4
are about 1000 times lower than the coefficients reported by Li
et al
.
Response to Comment on “Improper molecular ferroelectrics with simultaneous ultrahigh pyroelectricity and figures of merit”
Authors: Li Wenru , Tang Gang , Zhang Guangzu , Hong Jiawang , Huang Houbing , Wang Qing
Published: June 2022

Szafrański and Katrusiak stated that [Hdabco]ClO
4
and [Hdabco]BF
4
are proper ferroelectrics and exhibit much smaller pyroelectric coefficients than our results. We disagree with the arguments and provide a detailed answer highlighting misunderstandings in their interpretation.
An integrated photonics engine for unsupervised correlation detection
Authors: Ghazi Sarwat Syed , Brückerhoff-Plückelmann Frank , Carrillo Santiago García-Cuevas , Gemo Emanuele , Feldmann Johannes , Bhaskaran Harish , Wright C. David , Pernice Wolfram H. P. , Sebastian Abu
Published: June 2022

With more and more aspects of modern life and scientific tools becoming digitized, the amount of data being generated is growing exponentially. Fast and efficient statistical processing, such as identifying correlations in big datasets, is therefore becoming increasingly important, and this, on account of the various compute bottlenecks in modern digital machines, has necessitated new computational paradigms. Here, we demonstrate one such novel paradigm, via the development of an integrated phase-change photonics engine. The computational memory engine exploits the accumulative property of Ge
2
Sb
2
Te
5
phase-change cells and wavelength division multiplexing property of optics in delivering fully parallelized and colocated temporal correlation detection computations. We investigate this property and present an experimental demonstration of identifying real-time correlations in data streams on the social media platform Twitter and high-traffic computing nodes in data centers. Our results demonstrate the use case of high-speed integrated photonics in accelerating statistical analysis methods.
Luminescence sediment tracing reveals the complex dynamics of colluvial wedge formation
Authors: Gray Harrison , DuRoss Christopher , Nicovich Sylvia , Gold Ryan
Published: June 2022

Paleoearthquake studies that inform seismic hazard rely on assumptions of sediment transport that remain largely untested. Here, we test a widespread conceptual model and a new numerical model on the formation of colluvial wedges, a key deposit used to constrain the timing of paleoearthquakes. We perform this test by applying luminescence, a sunlight-sensitive sediment tracer, at a field site displaying classic colluvial wedge morphostratigraphy. The model and data comparison reveals complex sediment transport processes beyond the predictions of either conceptual or numerical models, including periods of simultaneous debris and wash facies forming processes, erosion, and reworking. These processes could lead to preservation bias, such as incomplete or overinterpretable paleoearthquake records, given the right environmental conditions. Attention to the site-specific mechanics of fault zone depositional systems, such as via sediment tracing, may buffer against the possible effects of preservation bias on paleoseismic study.
Formation of the elusive tetrahedral P
3
N molecule
Authors: Zhang Chaojiang , Zhu Cheng , Eckhardt André K. , Kaiser Ralf I.
Published: June 2022

The tetrahedral 1,2,3-triphospha-4-azatricyclo [1.1.0.0
2,4
] butane (P
3
N) molecule—an isovalent species of phosphorus (P
4
)—was prepared in low-temperature (5 K) phosphine-nitrogen ices and was identified in the gas phase through isomer-selective, tunable, soft photoionization reflectron time-of-flight mass spectrometry. Theoretical calculations reveal that the substitution of a single phosphorus atom by nitrogen in the P
4
molecule results in enhanced spherical aromaticity while simultaneously increasing the strain energy from 74 to 195 kJ mol
−1
. In P
3
N, the P─P bond is shortened compared to those in P
4
by 3.6 pm, while the P─N─P bond angle of 73.0° is larger by 13.0° compared to the P─P─P bond angle of 60.0° in P
4
. The identification of tetrahedral P
3
N enhances our fundamental understanding of the chemical bonding, electronic structure, and stability of binary, interpnictide tetrahedral molecules and reveals a universal route to prepare ring strained cage molecules in extreme environments.
A Two Amino Acid Duplication, L167E168, in the Ω-Loop Drastically Decreases Carbapenemase Activity of KPC-53, a Natural Class A β-Lactamase
Authors: Piccirilli Alessandra , Cherubini Sabrina , Celenza Giuseppe , Rossolini Gian Maria , Brisdelli Fabrizia , Segatore Bernardetta , Principe Luigi , Luzzaro Francesco , Andriani Lilia , Amicosante Gianfranco , Perilli Mariagrazia
Published: June 2022

KPC-53 enzyme is a natural KPC variant which showed a duplication of L167E168 residues in the Ω-loop structure. The
bla
KPC-53
gene was cloned both into pBC-SK and pET-24a vectors, and the recombinant plasmids were transferred by transformation in
Escherichia coli
competent cells to evaluate the antimicrobial susceptibility and to produce the enzyme.
Microbial Turnover and Dispersal Events Occur in Synchrony with Plant Phenology in the Perennial Evergreen Tree CropCitrus sinensis
Authors: Ginnan Nichole A. , De Anda N. Itzel , Campos Freitas Vieira Flavia , Rolshausen Philippe E. , Roper M. Caroline
Published: June 2022

Research at the forefront of plant microbiome studies indicates that plant-associated microbes can alter the timing of plant development (phenology). However, it is unclear if host phenological stage affects microbial community assembly.
Divergent Viruses Discovered in Swine Alter the Understanding of Evolutionary History and Genetic Diversity of the
Respirovirus
Genus and Related Porcine Parainfluenza Viruses
Authors: Zhao Jin , Sun Jiumeng , Li Xinxin , Xing Gang , Zhang Yifang , Lai Alexander , Baele Guy , Ji Xiang , Su Shuo
Published: June 2022

Livestock have emerged as critically underrecognized sources of paramyxovirus diversity, including pigs serving as the source of Nipah virus (NiV) and swine parainfluenza virus type 3, and goats and bovines harboring highly divergent viral lineages. Here, we identified a new species of
Respirovirus
genus named PPIV-2 in swine and proposed to revise the species demarcation criteria of the
Respirovirus
genus.
Allantodapsone is a Pan-Inhibitor of Staphylococcus aureus Adhesion to Fibrinogen, Loricrin, and Cytokeratin 10
Authors: Prencipe Filippo , Alsibaee Aishah , Khaddem Zainab , Norton Padraig , Towell Aisling M. , Ali Afnan F. M. , Reid Gerard , Fleury Orla M. , Foster Timothy J. , Geoghegan Joan A. , Rozas Isabel , Brennan Marian P.
Published: June 2022

S. aureus
colonization of the nares and the skin provide a reservoir of bacteria that can be transferred to wounds that can ultimately result in systemic infections. Antibiotic resistance can make these infections difficult to treat with significant associated morbidity and mortality. We have identified and characterized a first-in-class small molecule inhibitor of the
S. aureus
clumping factors A and B, which has the potential to be developed further as a colonization inhibitor.
Curettage and electrodessication combined with photodynamic therapy in the treatment of large squamous cell carcinomas in unfit and frail patients
Authors: Luu Henrik , Cornefjord Måns , Svensson Åke , Svensson Henry
Published: June 2022

A Caucasian female patient in her 90s was referred to the department of plastic and reconstructive surgery for surgical removal of a large invasive squamous cell carcinoma on the anterior chest wall. A skin biopsy prior to the referral indicated that the tumour was moderately differentiated. The patient suffered from severe congestive heart failure with a mechanical valve prosthesis and atrial fibrillation, and was therefore treated with anticoagulants. Hence, a surgical procedure would be hazardous. Therefore, other treatment options were considered. The principal aim was to reduce the amount of tumour tissue to an appropriate size suitable for later excision with primary wound closure. After interdisciplinary discussions, curettage and electrodessication combined with photodynamic therapy was judged the best alternative treatment in this case. At the 1.5 years follow-up after the intervention there was no indication for further surgery. The patient was at that stage content with the treatment and its outcome.
Deep Transfer Learning-Based Fall Detection Approach Using IoMT-Enabled Thermal Imaging-Assisted Pervasive Surveillance and Big Health Data
Authors: Rezaee Khosro , Khosravi Mohammad R. , Neshat Najmeh , Moghimi Mohammad Kazem
Published: June 2022

People’s need for healthcare capacity has become increasingly critical as the elderly population continues to grow in most communities. Approximately 25–47% of seniors fall annually, and early detection of poor balance can significantly reduce their risk. Automated fall detection with big data analytics is key to maintaining the safety of the elderly in smart cities. Visible image systems (VIS) in smart buildings, on the other hand, visible image systems (VIS) in smart buildings may compromise the privacy of seniors by enabling technologies for intelligent big data analytics (IBDA). Thermal imaging (TI) is less obtrusive than visual imaging and can be used in combination with machine vision to perform a wide range of IBDAs. In this study, we present a novel two-step method for detecting falls in TI frames using deep learning (DL). As the first step, tracking tools are used to locate people’s locations. A novel modified deep transfer learning (TL) technique is used to classify the trajectory created by the tracking approach for people who are at risk of falling. Fall detection by the IBDA will be connected to the Internet of medical things (IoMT) and used as smart technology in the process of big data-assisted pervasive surveillance and health analytics. According to an analysis of the publicly available thermal fall dataset, our method outperforms traditional fall detection methods, with an average error of less than 3%. Additionally, IoMT platforms facilitate data processing, real-time monitoring and healthcare management. Our smart scheme for using big data analytics to enable intelligent decisions is compatible with the various spaces and provides a comfortable and safe environment for current and future elderly people.