bluuebunny/crossref_metadata_2025 huggingface dataset:
Phase 3 randomized study of loncastuximab tesirine plus rituximab versus immunochemotherapy in patients with relapsed/refractory (R/R) diffuse large B-cell lymphoma (DLBCL): LOTIS-5.
Authors: Hamadani Mehdi , Linhares Yuliya , Gandhi Mitul , Chung Michael , Adamis Helena , Ungar David , Carlo-Stella Carmelo
Published: June 2021

TPS7574

Background: Patients (pts) with DLBCL for whom frontline therapy is unsuccessful and who are ineligible for autologous stem cell transplantation have poor outcomes with salvage therapy. Single-agent loncastuximab tesirine (Lonca), an antibody-drug conjugate comprising a humanized anti-CD19 monoclonal antibody conjugated to a pyrrolobenzodiazepine dimer (PBD) toxin, showed antitumor activity and manageable toxicity in pts with R/R B-cell non-Hodgkin lymphoma in a Phase 1 trial (Hamadani et al. Blood 2020; blood.2020007512) and in pts with R/R DLBCL in a Phase 2 trial (Caimi et al. Blood 2020; 136(Suppl 1):35–37). Rituximab (R) is part of standard immunochemotherapy for DLBCL, both as frontline therapy and in subsequent treatments. LOTIS-5 aims to evaluate Lonca + R (Lonca-R) versus (vs) standard immunochemotherapy of R + gemcitabine + oxaliplatin (R-GemOx) in pts with R/R DLBCL. Methods: This is a Phase 3 randomized, open-label, 2-part, 2-arm, multicenter study (NCT04384484). A non-randomized safety run-in (Part 1) will compare the safety of Lonca-R with previous safety data for Lonca after the first 20 pts have completed Cycle 1. Part 2 will be started if no significant increase in toxicity occurs; ̃330 pts will be randomized 1:1 to receive Lonca-R or R-GemOx. The primary objective of the study is to evaluate the efficacy of Lonca-R vs R-GemOx. The primary endpoint is progression-free survival by independent review. Secondary endpoints include overall survival; objective response rate; complete response rate; duration of response; frequency and severity of adverse events; changes from baseline in safety laboratory and clinical variables; concentration and pharmacokinetic parameters of Lonca (conjugated and total antibody, and unconjugated warhead); immunogenicity; and changes in patient-reported outcomes. Time-to-event endpoints will be assessed for the intent-to-treat population using a stratified log-rank test. The dosing regimen of Lonca-R in both parts of the study will be 150 µg/kg Lonca + 375 mg/m2 R every 3 weeks (Q3W) for 2 cycles and then 75 µg/kg Lonca + 375 mg/m2 R for 6 cycles. The dose regimen of R-GemOx in Part 2 will be 375 mg/m2 R, 1000 mg/m2 Gem, and 100 mg/m2 Ox Q2W for 8 cycles. Key inclusion criteria include age ≥18 years; pathologic diagnosis of DLBCL (including pts with DLBCL transformed from indolent lymphoma) or high-grade B-cell lymphoma with MYC and BCL2 and/or BCL6 rearrangements; ≥1 line of prior systemic therapy; not a candidate for stem cell transplantation; and measurable disease per 2014 Lugano Classification. The study opened in September 2020 and enrollment is ongoing. The trial design was presented at 62nd American Society of Hematology Annual Meeting and Exposition, December 5–8, 2020. Research Funding: ADC Therapeutics SA. Clinical trial information: NCT04384484.
DREAM3R: Durvalumab with chemotherapy as first-line treatment in advanced pleural mesothelioma—A phase 3 randomized trial.
Authors: Forde Patrick M. , Nowak Anna K. , Kok Peey-Sei , Brown Chris , Sun Zhuoxin , Anagnostou Valsamo , O'Byrne Kenneth John , Yip Sonia , Cook Alistair , Lesterhuis Willem Joost , Hughes Brett Gordon Maxwell , Pavlakis Nick , Brahmer Julie R. , Kindler Hedy L. , Tsao Anne S. , Zauderer Marjorie Glass , Ramalingam Suresh S. , Stockler Martin R.
Published: June 2021

TPS8586

Background: Standard first line treatment for unresectable malignant pleural mesothelioma (MPM) is platinum-based chemotherapy with pemetrexed. Two recent, single-arm, phase 2 trials (DREAM1 and PrE05052) combining the PD-L1 inhibitor durvalumab and standard first line cisplatin and pemetrexed (CP) exceeded pre-specified criteria for proceeding to phase 3. DREAM3R aims to determine the effectiveness of adding durvalumab to first line CP chemotherapy in advanced MPM. Methods: Treatment-naïve patients with advanced MPM will be randomised (2:1) to EITHER durvalumab 1500 mg every 3 weeks plus doublet chemotherapy (cisplatin 75 mg/m2 and pemetrexed 500 mg/m2) every 3 weeks for 4-6 cycles, followed by durvalumab 1500 mg every 4 weeks until disease progression, unacceptable toxicity or patient withdrawal; OR doublet chemotherapy alone for 4-6 cycles, followed by observation. The target sample size is 480 patients (320 durvalumab, 160 control) recruited over 27 months, with follow up for an additional 24 months. This provides over 85% power if the true hazard ratio for overall survival is 0.70, with 2-sided alpha of 0.05, assuming a median survival of 15 months in the control group. Key inclusion criteria: MPM of any histological subtype; measurable disease as per RECIST 1.1 modified for mesothelioma (mRECIST 1.1) without prior radiotherapy to these sites; ECOG PS 0-1; and, adequate hematologic, renal, and liver function tests. Key exclusion criteria: prior systemic anticancer treatment for MPM; diagnosis based only on cytology or fine needle aspiration biopsy; contraindication to immunotherapy; and conditions requiring immunosuppressives or corticosteroids. Stratification: Age (18-70 years vs. > 70), sex, histology (epithelioid vs. non-epithelioid), and region (USA vs. ANZ). The primary endpoint is overall survival. Secondary endpoints include progression-free survival; objective tumour response (by mRECIST 1.1 and iRECIST); adverse events; health-related quality of life; and healthcare resource use. Tertiary correlative objectives are to explore and validate potential prognostic and/or predictive biomarkers (including features identified in the DREAM and PrE0505 studies, PD-L1 expression, tumour mutation burden, nuanced genomic characteristics, and HLA subtypes) in tissue and serial blood samples. An imaging databank will be assembled for validation of radiological measures of response, and studies of possible radiomic biomarkers in mesothelioma. Clinical trial information: NCT04334759. and ACTRN 12620001199909.
Assessment of the hyperbaric oxygen therapy effects in distal femoral necrosis using hyperspectral imaging
Authors: CALIN Mihaela Antonina , MACOVEI Adrian , MANEA Dragos
Published: May 2021

Introduction. Hyperbaric oxygen therapy is a treatment option for an increasing number of conditions. The aim of this study was to assess its therapeutic effects in femoral condylar necrosis as well as in normal tissue using hyperspectral imaging. Material and method. A 47-year-old female patient diagnosed with avascular necrosis of the medial femoral condyle was included in this study. The patient received hyperbaric oxygen therapy for two consecutive days (the first day: three stages of 30 min each, separated by two breaks of 5 min at pO2 = 2 ATA; the second day: three stages of 30 min each, separated by two breaks of 5 min at pO2 = 2.4 ATA). The effects of hyperbaric oxygen therapy on the affected area (patient’s knee) and normal (patient’s hand) tissues oxygenation were assessed before and after each treatment session using hyperspectral imaging. Results and discussions. The results showed that hyperspectral imaging is quite good for monitoring the hyperbaric oxygen therapy efficacy in affected areas, even with deep tissue problems. Conclusions. In conclusion, the hyperspectral imaging-based approach for monitoring hyperbaric oxygen therapy could support physicians in extracting prognostic information and making the right treatment decisions.

Keywords: bone necrosis, image analysis, maps, oxyhemoglobin, deoxyhemoglobin, oxygen saturation,
The values, perception and attitudes of potential domestic tourists regarding the medical tourism offer of Romania
Authors: ILE Larisa-Florența , HOLOSTENCU Luciana-Floriana , ȚIGU Gabriela , DIACONESCU Vlad
Published: May 2021

Introduction. Apparently medicine and tourism have represented for a while distinct domains, both in terms of research and even in popular culture. While medicine is widely known as dedicated exclusively to healing and treating patients suffering from various diseases, tourism, popular since ancient times in relation to healing, is based on a person’s motivation towards obtaining a pleasant experience in optimal conditions that already require the existence of a good state of health. Considering the emergence of new challenges in medicine, mostly in terms of demand, there is a phenomenon of directing preferences or needs in order to obtain medical services in a relaxing touristic environment. Due to the rapid development of medical tourism, we consider opportune to study this phenomenon, both from the perspective of a social and economic impact and from the need to reorganize the tourism activity, emphasized with new forms and modern concepts.
Material and method. As a limited number of research can be found related to medical tourism, and generally covers travelling for medical treatments or interventions, and also a few publications are dealing with theoretical aspects of this form of tourism, the main purpose of the article is to bring a scientific contribution to the global field of medical tourism, especially regarding the tourist expectations and attitudes towards an internal medical tourism offer. Using a quantitative research methodology, we aimed to achieve the following secondary objectives: identifying the interest, intention and reasons of respondents to practice medical tourism, establishing the level of confidence in the medical specialization of certain cities, assessing the level of knowledge and general perception on a treatment specifics in spa resorts structured in galaxy clusters.
Results and discussions. Focusing on both national and international research, we have reached the conclusion that there is a lack of specific statistical indicators to analyze or compare the phenomenon of medical tourism. The shortcomings that are considered in the research may be caused mainly by inconsistencies of defining different concepts related to medical tourism or the confusion generated by the use of terms specific to medical or health tourism. Thus, the main objective of our research is to identify relevant aspects regarding the values, perception and attitudes of potential domestic medical tourists towards Romania’s medical tourism offer.
Conclusions. There are certain limitations to our research, but it can surely become a basis for further developments regarding galaxy clusters and their impact in relation to a tourist’s needs.

Keywords: medical tourism, spa resorts, medical providers, medical services demand, balneary tourism,
The role of cardiac rehabilitation after Streptococcus agalactiae Infective Endocarditis with Septic Embolic Complication in an Elderly Patient: Case Report
Authors: OPREA Alexandru , SCURTU Razvan , ENCICA Svetlana , LAPUSAN Emanuela , SERBAN Adela , SACUI Diana , BLENDEA Dan
Published: May 2021

Introduction. In the past, Streptococcus agalactiae was known to be associated with invasive infections in pregnant women and newborns. More recently, given a more appropriate antibiotic prophylaxis and treatment, the incidence among pregnant women and infants diminished. However, an increasing number of cases with infective endocarditis with Streptococcus agalactiae has been reported in the recent years in older patients with underlying comorbidities.
Case report. An 80-year-old female patient presented with dyspnea, weight loss, fever, fatigue, chills, dry cough and bilateral lower limb edema. The work-up revealed complicated infective endocarditis with Streptococcus agalactiae on the native aortic valve with severe aortic regurgitation as a result of the valvular destruction and a metastatic spleen abscess. Antibiotic treatment was started with resolution of the fever and chills. The patient however developed congestive heart failure due to the valvular regurgitation. A decision was made to proceed urgently with aortic valve replacement and splenectomy, which were performed at the same time, followed by a good recovery.
Results and discussion. An increasing number of cases with IE with GBS in elderly patients has been reported in the recent years, with high rate of complications and mortality. The underlying comorbidities are important risk factors for S. agalactiae IE. Considering our case, a patient in her eighties with significant abdominal surgical history and multiple medical conditions could be a typical host. Recovery after cardiac surgery is one of the most important indications of physical training. This includes patients post-coronary artery bypass grafting, after valve prosthetic replacement, after surgery for congenital diseases and after heart transplantation. Early mobilization is particularly important in avoiding immobility and cardiac deconditioning.
Conclusions. Despite the fact that mortality in Group B Streptococcus endocarditis is 40%, a combined medical and surgical strategy individualized to the specific situation of each patient have led to a positive outcome in a number of cases. We present such a combined treatment approach in a case of complicated infective endocarditis with metastatic spleen abscess in an elderly patient. The aortic valve replacement and splenectomy were performed at the same time.

Keywords: endocarditis, septic emboli, valve replacement, splenectomy
Η Αγία Γραφή στην Πατερική Γραμματεία
Authors: Δομουχτσής Κωνσταντίνος
Published: June 2021

Η παρούσα διατριβή έχει σκοπό τη μελέτη της χρήσης της Αγίας Γραφής στην Πατερική γραμματεία με την βοήθεια της επιστήμης της Πληροφορικής. Για την υλοποίηση αυτού του σκοπού αξιοποιήθηκε η βάση δεδομένων που είχε δημιουργηθεί από τον γράφοντα στα πλαίσια της μεταπτυχιακής του εργασίας (Οι Σειρές Catenae ως ερμηνευτικό εργαλείο για τη μελέτη της Αγίας Γραφής. Από τη χειρόγραφη παράδοση στην Τεχνολογία της Πληροφορίας. Πιλοτική εφαρμογή στο Βιβλίο της Γένεσης, ΑΠΘ 2013). Στη μεγάλων διαστάσεων αυτή βάση δεδομένων εμπεριέχεται όλο το κείμενο της Αγίας Γραφής στην ελληνική γλώσσα, με προοπτική να περιλάβει το κείμενό της και σε άλλες γλώσσες, οργανωμένο και δομημένο σύμφωνα με τις απαιτήσεις και τους κανόνες μιας βάσης δεδομένων. Το κείμενο αυτό συνδυάστηκε με την ελληνική έκδοση Patrologia Graeca του J.P. Migne μέσω ενός εκτενούς καταλόγου αναφορών των πατερικών κειμένων στην Βίβλο, που καταρτίσθηκε από τους καθηγητές Στέργιο Σάκκο και Παυσανία Κουτλεμάνη (Κέντρο Πατερικών Εκδόσεων, Αθήνα 1985).Με βάση τις δυνατότητες όμως που παρέχει σήμερα η υπολογιστική τεχνολογία και εκμεταλευόμενοι τη βάση δεδομένων που ήδη δημιουργήσαμε, εφαρμόσαμε νέες ψηφιακές μεθόδους ανάλυσης, μεγάλων σε όγκο και πολυπλοκότητα συλλογών δεδομένων με στόχο την εξαγωγή και διαχείριση χρήσιμων προτύπων γνώσης, έτσι ώστε η «Ψηφιακή Ερμηνευτική Σειρά στην Αγία Γραφή Ελλήνων Πατέρων της Εκκλησίας» να αποτελέσει ένα πλήρες και αξιόπιστο ψηφιακό εργαλείο διαχείρισης δεδομένων, ανάκτησης πληροφορίας και εξόρυξης γνώσης (Data Management, Information Retrieval and Data mining) που να λειτουργεί ως δεξαμενή επιστημονικών πληροφοριών για όλους τους ερευνητές με βάση τη συσχέτιση της χριστιανικής λογοτεχνίας με την Αγία Γραφή. Αυτό το πληροφοριακό σύστημα μπορεί να προσφέρει σημαντική βοήθεια σε όλους τους ερευνητές των ανθρωπιστικών επιστημών, και δικαιολογεί τον πρωταγωνιστικό ρόλο που θα πρέπει να έχει η έρευνα στην πολιτιστική κληρονομιά της Χριστιανικής λογοτεχνίας.
Introduction
Authors: -
Published: May 2021

-
Of Promises Delivered and Failed: Post‑9/11 America through the Eyes of The Reluctant Fundamentalist by Mohsin Hamid
Authors: Gasztold Brygida
Published: May 2021

Mohsin Hamid’s novel The Reluctant Fundamentalist offers an interesting voice in the discussion about post‑9/ 11 America and shows how a successful immigrant story changes to a racially charged case of ethnic discrimination. Despite the fact that Hamid’s protagonist may believe in his successful assimilation into American culture, the general feeling of xenophobia that gripped American society in the wake of the 9/11 attacks forces him to re‑evaluate his position. His personal dilemma, oscillating between the desire for material affluence and ethnic loyalty, is presented in a broader context that depicts the world divided along financial and political lines. The conflicting pull between the economic interests lying in the West – represented by the U.S. and the subaltern position of less‑developed countries, such as Pakistan – becomes a source of anguish for the protagonist. This paper examines how the borders of conflict shift from public to personal, complicating the issue of identity for Muslim immigrants. The discourse of the war on terror is presented from the perspective of an Other, offering a counter‑narrative to the hegemonic narrative of Western culture.
Paleoconservatism and the Issue of Immigration and Multiculturalism
Authors: Machnik Barbara
Published: May 2021

This article deals with paleoconservative attitudes toward the issue of immigration to the United States and the problem of multiculturalism and assimilation on American soil. Representatives of paleoconservatism present these phenomena as a significant threat to the American way of life. Their words are filled with anxiety for the future of American society, which is instilled with the positive meaning of the idea of open borders, and which is becoming permeated with alien cultures and losing its own cultural identity. Starting with an explanation of the essence of the American nation’s homogeneity, this article presents the threats which come with the ‘mixing’ of cultures and liberal immigration as well as phenomena directly linked to such immigration, namely the problem of terrorism and Islam.
Research Roundup
Authors: Winter George
Published: June 2021

George Winter provides an overview of recently published articles that are of interest to practice nurses. Should you wish to look at any of the papers in more detail, a full reference is provided.
Geometry of Ball Seat Valves
Authors: Fischer Felix , Bauer Niklas , Murrenhoff Hubertus , Schmitz Katharina
Published: June 2021

The macroscopic geometry of ball seat valves is important for the quality of the seal. This works discusses the influence of different geometric properties on the contact area, the contact pressure and their relation to the leakage. The leakage is calculated using the results of finite element method (FEM) calculations and Persson’s percolation based method. The following properties of the seat are examined: the angle, the curvature and the eccentricity.
Case Study on PV Integrated Grid Independent Electric Bus
Authors: Vantagodi Nihal Vishnu , Rao Anand Raghavendra
Published: June 2021

In this paper, it has been theoretically and conceptually examined the techni-cal, design, and economic viability of using Photovoltaic (PV) technologyin combination with battery operated Electric vehicle (EV) in Public Bussector in India, where solar energy is readily available. The study is furtheranalyzed to propose the utilization and economics of “PV integrated EV”technology along with solar and battery integrated solution. The availablebattery chemistries are studied, and the best suited solution based on parame-ters such as cost, weight NMC battery is chosen. Finally, the number of solarpanel and battery requirement is calculated based on the power consumptionof the vehicle and concluded.
Optical nano-imaging via microsphere compound lenses working in non-contact mode
Authors: Wu Guangxing , Hong Minghui
Published: May 2021

Microsphere lens for nano-imaging has been widely studied because of its superior resolving power, real-time imaging characteristic, and wide applicability on diverse samples. However, the further development of the microsphere microscope has been restricted by its limited magnification and small field-of-view. In this paper, the microsphere compound lenses (MCL) which allow enlarged magnification and field-of-view simultaneously in non-contact imaging mode have been demonstrated. A theoretical model involving wave-optics effects is established to guide the design of MCL for different magnifications and imaging configurations, which is more precise compared with common geometric optics theory. Experimentally, using MCL to image the specimen with a tunable magnification from 2.8× to 10.3× is realized. Due to the enlarged magnification, a high-resolution target with 137 nm line width can be resolved by a 10× objective. Besides, the field-of-view of MCL is larger than that of a single microsphere and can be further increased through scanning working manner, which has been demonstrated by imaging a sample with ∼76 nm minimum feature size in a large area. Prospectively, the well-designed MCL will become irreplaceable components to improve the imaging performances of microsphere microscope just like the compound lens in the conventional macroscopic imaging system.
Towards underwater coherent optical wireless communications using a simplified detection scheme
Authors: Tang Xinke , Kumar Rupesh , Sun Caiming , Zhang Long , Chen Zhen , Jiang Rui , Wang Hongjie , Zhang Aidong
Published: May 2021

In this paper, an effective method of underwater coherent optical wireless communication (UCOWC) with a simplified detection scheme is proposed. The proof-of-concept experiments with M-ary PSK have been conducted with a common laser used for the signal source and local oscillator (LO). The BER performance has been evaluated at different underwater channel attenuations and the maximum achievable attenuation length (AL) with a BER below the forward error correction (FEC) limit of 3.8×10−3 is investigated. The tested system offers data rates of 500 Mbps, 1 Gbps, and 1.5 Gbps with the BPSK, QPSK and 8PSK modulated signals, respectively. The corresponding maximum achievable attenuation lengths are measured as 13.4 AL 12.5 AL, and 10.7 AL. In addition, the performance degradation of the practical system with separate free running lasers for the signal and LO is also estimated. To the best of our knowledge, the UCOWC system is proposed and experimentally studied for the first time. This work provides a simple and effective approach to take advantages of coherent detection in underwater wireless optical communication, opening a promising path toward the development of practical UCOWC with next-generation underwater data transmission requirements on the capacity and transmission distance.
Achieving efficient inverse design of low-dimensional heterostructures based on a vigorous scalable multi-task learning network
Authors: Du Shiyin , You Jie , Tang Yuhua , Ouyang Hao , Tao Zilong , Jiang Tian
Published: May 2021

A scalable multi-task learning (SMTL) model is proposed for the efficient inverse design of low-dimensional heterostructures and the prediction of their optical response. Specifically, several types of nanostructures, including single and periodic graphene-Si heterostructures consisting of n×n graphene squares (n=1∼9), 1D periodic graphene ribbons, 2D arrays of graphene squares, pure Si cubes and their periodic array counterparts, are investigated using both traditional finite element method and SMTL network, with the former providing training data (optical absorption) for the latter. There are two important algorithms implemented in SMTL model: one is the normalization mechanism that makes different parameters of different structures on the same scale, ensuring that SMTL network can deal with tasks with different dataset impartially and without bias; the other one is used to capture the impact of nanostructures’ dimensions on their optical absorption and thus improve the generalization ability of SMTL. Utilizing SMTL model, we first study the absorption property of the multiple shaped nanostructures and look deeper into the impacts of n×n graphene squares and Si cuboid on the optical absorption of their heterostructures. Equally important, the multi-structure inverse design functionality of SMTL is confirmed in this context, which not only owns high accuracy, fast computational speed, and excellent generalizable ability, but also can be applied to contrive new structures with desired optical response. This work adds to the rapidly expanding field of inverse design in nanophotonics and establishes a multi-task learning framework for heterostructures and more complicated nanoparticles.
Ensemble averaging laser speckle contrast imaging: statistical model of improvement as function of static scatterers
Authors: Földesy Péter , Siket Máté , Jánoki Imre , Demeter Kornél , Nagy Ádám
Published: May 2021

The appearance of the common artifacts of laser speckle contrast imaging (LSCI), namely the granularity in flow rate estimation caused by static scatterers, is a well-known phenomenon. This artifact can be greatly reduced in spatial speckle contrast calculation using interframe decorrelated illumination, forcing true ensemble averaging. We propose a statistical model, which describes the effect of multiple image acquisitions on the contrast map quality when the illumination stable and when the illumination is decorrelated frame by frame. We investigate the improvement as a function of the ratio of dynamic and static scatterers by formulating a statistical distribution based model, using in simulation, flow phantom and in vivo experiments. Our main finding is that the ensemble averaging yields limited improvement in several practical cases due to the highly heterogeneous scatterer structure of living tissues.
Modelling non-Markovian dynamics in photonic crystals with recurrent neural networks
Authors: Burgess Adam , Florescu Marian
Published: May 2021

We develop a recurrent neural network framework to model the non-Markovian dynamics exhibited by two-level atoms interacting with the radiation reservoir of a photonic crystal. Despite the strong non-Markovianity of the atomic dynamics induced by the rapid spectral variation in photonic density of states of the photonic reservoir, our recurrent neural network approach is able to capture precise details in the atomic evolution, including the fractional steady-state atomic population inversion and spectral splitting of the atomic transition. We demonstrate the robustness of the recurrent neural network setup against reduced data sets and its effectiveness to deal with systems of increased complexity.
The epizootic situation of cattle moraxellosis in several economic entities of the Republic of Kazakhstan
Authors: Ivanov N. P. , Bakiyeva F. A. , Namet A. M. , Sattarova R. S. , Issakulova B. Zh. , Akmyrzayev N. Zh.
Published: May 2021

Background and Aim: Infectious bovine keratoconjunctivitis (IBK; conjunctivitis) is a widespread eye disease in cattle. In 1960, the Gram-negative bacillus Moraxella bovis was discovered as one of IBK's etiological causal agents. This study aimed to clarify the epidemiological (epizootic) situation of cattle moraxellosis in the Republic of Kazakhstan. The study also maps the quantitative and qualitative indicators of the epidemiological (epizootic) process to develop more effective antiepizootic measures. Materials and Methods: We clinically examined both imported and local cattle species based on existing epidemiological (epizootological) units of economic entities in Kazakhstan. Then, we selected biomaterials for laboratory tests to screen for moraxellosis. Results: We clarified the epizootic situation for moraxellosis of cattle in Kazakhstan using data from the Meat Union of Kazakhstan, veterinary reports from the Veterinary Control and Surveillance Committee of the Ministry of Agriculture, Kazakhstan, and our results, obtained during visits to farms in the various regions of the republic. Conclusion: Based on the data of the conducted studies, we developed epizootic visualization maps with quantitative indicators of the cattle moraxellosis epizootic-transfer processes within various regions of Kazakhstan for 2019. The data obtained from studies of the properties of the isolated cultures compared with the characteristics of reference strains gave grounds to classify them as belonging to the Moraxella genus.
A Study of Relationship of Bone Mineral Density with Age, Body Mass Index, Obesity and Serum Magnesium Level
Authors: Jaiswal Jyoti , Mahilange Anchala
Published: May 2021

BACKGROUND Menopause is defined as the permanent cessation of menstruation following loss of ovarian activity. One of the most important problems associated with menopause is osteoporosis. This study was conducted to evaluate the relationship between bone mineral density, body mass index, age, serum calcium, and serum magnesium in 120 women. METHODS Present study was an observational study done from Feb 2017 to July 2017 in Pt. J.N.M. Medical College to evaluate the relationship of bone mineral density with age, body mass index (BMI), obesity and serum magnesium in 120 postmenopausal women. A detailed medical, obstetrical, menstrual, and drug history was recorded in a proforma designed for the study. Past fracture history, family history of fracture and osteoporosis, socioeconomic status, occupation, educational level and weightbearing exercises were collected and recorded. RESULTS Average age of women with normal bone health was 30.5 + 0.58 years, while the age of osteopenic and osteoporotic women was 43.11 + 6.79 years and 54.64 + 11.92 years respectively. Most of the osteopenic women belonged to the age group of 40 – 49 years. Osteoporotic patients (78.57 %) had a high (> 0.85) waist-hip ratio, while women with normal bone mineral density had a normal waist-hip ratio. Most of the women with normal bone mineral density (100 %), osteopenia (85.29 %) and osteoporosis (57.14 %) had normal serum magnesium levels. CONCLUSIONS We found that the bone mineral density reduced with advancing age, decreasing BMI and obesity, while we found no correlation of serum magnesium level with bone mineral density (BMD). KEY WORDS Bone Mineral Density, Body Mass Index, Perimenopause, Magnesium, Calcium
Cardiac Manifestations in Adult Sickle Cell Disease Patients at a Tertiary Care Hospital in Chhattisgarh, India
Authors: Shrivastava Smit , Chaudhary Animesh , Pandey Prabhat
Published: May 2021

BACKGROUND Sickle cell disease is the commonest haemoglobinopathy. Recent advanced therapeutic approaches are enabling the sickle cell patients to survive beyond adulthood. METHODS The study provides important data on cardiovascular abnormalities in sickle cell disorder in Chhattisgarh by employing a non-invasive method of two-dimensional colour Doppler echocardiography. RESULTS The present study suggests that sickle cell disease has association with left ventricular diastolic dysfunction and pulmonary artery hypertension and no association with other echocardiographic findings including left ventricular dimensions and functions. The association is further affected by the presence of moderate to severe anaemia (haemoglobin < 8.9 gm %), higher urea (> 19 mg / dL), creatinine (0.8 mg / dL) and diastolic blood pressures (< 69 mmHg). The age, gender and systolic blood pressures of the subject were not found to impact echocardiographic parameters. CONCLUSIONS The present study suggests that sickle cell disease affects left ventricular diastolic dysfunction and pulmonary artery hypertension but does not affect the other echocardiographic dimensions and functions. The association is further affected by the presence of moderate to severe anaemia, higher urea, creatinine and diastolic blood pressures. The age, gender and systolic blood pressure do not influence echocardiographic parameters. KEY WORDS Adult, Sickle Cell Disease, Echocardiography, Ventricular Function, Anaemia
Biodentine Total Pulpotomy as an Effective Alternative to Conventional Endodontic Therapy for Young Permanent Teeth – A Study from Calicut, India
Authors: Adyanthaya Amith , P Prathyusha , K Risana , Sivaraman Aparna , K Nazreen Ayub , Aloysious Reshma , C. R. Sangeetha , Nair Swetha S.
Published: May 2021

BACKGROUND The vitality of dental pulp is essential for long-term survival of the tooth. Vital pulp therapy (VPT) intends to maintain healthy pulp tissue by eliminating bacteria from the dentin-pulp complex. There are many treatment options for vital pulp therapy in extensively decayed teeth. Pulp capping or pulpotomy procedures rely upon an accurate assessment of the pulp status, and careful management of the remaining pulp tissue. We wanted to evaluate as to whether biodentine total pulpotomy is an effective alternative to conventional endodontic therapy for young permanent teeth. METHODS Full coronal pulpotomy was performed in young permanent molars diagnosed with acute irreversible pulpitis with Biodentine as the pulpotomy medicament. Follow up evaluation was done clinically and radiographically at 3, 6 and 12 months. RESULTS During follow-up periods clinical signs/symptoms were absent including pulpal pain, swelling or presence of sinus and percussion pain. Continuous root development and healing of periapical radiolucency were noticed in the study which were indicative of maintenance of vitality of the pulp. CONCLUSIONS Within the limitations of this clinical study, it is concluded that total pulpotomy with Biodentine has a promising scope in regenerative approaches in the treatment of carious young permanent teeth. KEY WORDS Biodentine, Coronal Pulpotomy, Permanent Teeth, Total Pulpotomy
Dental Caries and the Influence of Associated Factors – A Cross-Sectional Study
Authors: Ehsan Aliya , Afridi Jawwad Iqbal , Abid Hina , Yusuf Muhammad
Published: May 2021

BACKGROUND The study was carried out to determine the prevalence of dental caries among urban and suburban population in Pakistan to assess the association of dental caries with oral hygiene status, socioeconomic status, and dental service availability. METHODS A total of 200 patients was enrolled in this cross-sectional study. Decayed, filled, and missing teeth (DMFT), oral hygiene status, socioeconomic status (SES), and presence / absence of dental care facility were recorded. A specially designed proforma was used to record the data regarding oral hygiene practices, dental treatment availability and socioeconomic background, for the study. The data obtained was statistically analysed using SPSS version 15 software. Chi-square test was applied for association between categorical variables. Analysis of variance (ANOVA) was done to test the difference in DMFT scores of various age groups. Student t test was applied to test the difference in DMFT scores in both sexes. RESULTS Comparison of mean D, M and F status revealed a high tendency towards decayed teeth. Mean DMFT score was found to be 4.41. Maximum DMFT was recorded among 50 years and above age group, followed closely (2.39) by 40 - 49 years. Increased caries prevalence was seen in people with poor oral hygiene and belonging to low socioeconomic status. Caries rate was also high in areas with lack of dental care facilities. CONCLUSIONS Oral hygiene practices, dietary habits, and access to dental care services played an important role in prevalence of dental caries. Socio-economic status has been found to play an important role in access to dental care facilities. From the current report, importance for public health was noted; the socioeconomic status, educational status of parents, and family structure, affect oral health in under-privileged communities. The prevalence of dental caries also plays an important role in oral hygiene procedures, eating patterns, and access to dental care services. KEY WORDS Dental Caries, SES, Oral Hygiene, Dental Care Facility, DMFT.
Toward an Affective Sense of Life: Artificial Intelligence, Animacy, and Amusement at a Robot Pet Memorial Service in Japan
Authors: White Daniel , Katsuno Hirofumi
Published: May 2021

This essay analyzes the organization of Buddhist memorial services for robot pets in Japan against the backdrop of emerging markets for robots equipped with artificial emotional intelligence. It demonstrates how an evocative “sense of life” (seimeikan) becomes both a target of design for robotics engineers and an affective capacity of robot users who care for and through companion robots. Documenting how users cultivate a sense of amusement toward robots that neither neglects nor negates analytical distinctions between the artificial and the living but rather playfully holds them together in the figure of a living robot, the article illustrates how practices of care become affective tools for understanding life altered by developments in AI. Such findings render animacy as an open and exercisable capacity, responsive to technoscientific change, and generative of theoretical inspiration for how anthropologists might similarly exercise affect as a particularly productive method of fieldwork within machine-inclusive multispecies societies.

抄録

本論文は 感情認識AI（人工知能）を搭載した一般消費者向けロボットの登場を背景に営まれるようになった日本におけるペットロボットの法要について考察するものである。特に「生命感」の喚起がいかにロボット開発におけるデザインのターゲットになると同時に、ユーザーがロボットとケアを介した関係性を結ぶ際の情動的能力の所産の対象にもなっているかということを明らかにする。ロボットと接するなかでユーザー達は分析的に対置される人工物と生命体との違いを無視したり否定したりするのではなく、むしろそれらを享楽的に結合させてロボットの存在を捉えるアミューズメントの心を高めている。この記述を通して、本論文はロボットへのケアの実践が人工知能の発展によって変わりつつある生命のあり方を理解する情動的手段になっていることを描き出す。このような知見は、対象物に生物性や生物らしさを感じるアニマシーの知覚が柔軟で状況に応じて発揮することが可能な能力であり、科学技術の変化にも応じることが出来るということを表しているだけでなく、機械を含むマルチ・スピーシーズ社会における有益なフィールドワークの手法として人類学者自身もどのように情動をうまく取り込むことができるかという理論的な閃きを生成する契機にもなったのである。
The Limits of Corporate Chains and Brand Management: “Loyalty” and the Efficacy of Vernacular Markets in the Andes
Authors: Müller Juliane
Published: May 2021

This article offers a nuanced ethnographic description of the encounter between multinational corporations and the economic actors who distribute and commercialize their commodities. By analyzing the labor of lower-level employees and the strategies of the middle management of Samsung Electronics Bolivia against traders’ practices and understandings and the vernacular market infrastructure, I offer a substantive interpretation of the obstacles and unintended outcomes of corporate commodity chain and brand management as it expands into an “emerging” market such as that in Bolivia. Street vendors, shopkeepers, and wholesalers are teased with personalized attention, gifts, and monetary incentives to sell the high-priced premium brands and build legible inventory, but they have remained notoriously disloyal. By focusing on the agreements and tensions between corporations and traders about how to move, store, categorize, advertise, and price the products, this article engages with the literature on urban marketplace trade and commercial transactions, counterfeit commodities, and economic power in globalized markets and supply chains. To think about the appeal and effectiveness of vernacular market channels and arrangements offers a conceptual lens to critically address the efficiency paradigm in supply-chain thinking, as well as to analyze discrepancies and power struggles not only among economic actors (such as traders and corporations) but also between different forms of valuation that co-exist and compete in markets.

RESUMEN

Este artículo ofrece una detallada descripción etnográfica del encuentro entre empresas multinacionales y los actores económicos que distribuyen y comercializan sus mercancías. Al analizar la labor y las estrategias de los empleados de Samsung Electronics Bolivia frente a las prácticas y visiones de los comerciantes, así como la infraestructura social, material y afectiva del mercado vernáculo, ofrezco una interpretación sustantiva de los obstáculos en la gestión corporativa de la cadena de productos (supply chain management) y en el marketing (branding) a medida que se expanden hacia mercados “emergentes” como el boliviano. Al centrarme en los acuerdos y las tensiones entre las empresas y los comerciantes sobre cómo mover, almacenar, categorizar, valorar y comercializar los productos, este artículo reconsidera la literatura sobre el comercio de las plazas de mercado, las mercancías falsificadas y los procesos de economización. Pensar en el atractivo y la eficacia de los canales y arreglos del mercado vernáculo ofrece una lente conceptual para abordar críticamente el paradigma de la eficiencia en el pensamiento sobre las cadenas de suministro, y permite observar discrepancias y luchas de poder no sólo entre unos agentes económicos (como los comerciantes y las empresas), sino también entre diferentes formas de valoración que conviven y compiten en los mercados.
Becoming-After: The Lives and Politics of Quinine’s Remains
Authors: Middleton Townsend
Published: May 2021

This article explores the aftermath of quinine in India. Derived from cinchona, the fever tree, quinine was once malaria’s only remedy—and, as such, vital to colonial power. But it has left grave uncertainty in its wake. Today, little market exists for Indian quinine, but government cinchona plantations established by the British remain in Darjeeling. What will become of these dilapidated plantations and their 50,000 inhabitants is unclear. Crumbling quinine factories and overgrown cinchona may evoke ruination, but these remains are not dead. They have instead become the site of urgent efforts—and a periodically charged politics—to redefine land and life for the twenty-first century. This essay develops an analytics of becoming-after to ask not only, how do empires and human beings become-with world-historical substances like quinine but also, what do we make of life after they run their course?
Legal Care and Friction in Family Detention
Authors: Routon Erin
Published: May 2021

The modern instantiation of migrant family detention in the United States has resulted in the creation of carceral spaces in which conflict and care intermingle in everyday encounters. While legal advocates traversing these spaces offer critical aid to the detained, asylum-seeking parents and children confined within, legal advocacy is rarely recognized as caregiving work. Drawing from my ethnographic research with voluntary legal advocates working at family detention facilities in South Texas, this article demonstrates the potential for deploying a lens of care to such encounters, which I ultimately frame as “legal care.” I argue that cross-disciplinary conceptualizations of care, which emphasize its interdependency, relationality, and contested terrains (Puig de la Bellacasa 2017), as well as its practices as being marked by a continuous tinkering (Mol 2010), offer windows to reconfigurations of care and power that reside amid both the mundane and unpredictable frictions that characterize these environments.
PEMODELAN JUMLAH KASUS DEMAM BERDARAH DENGUE (DBD) DI JAWA TENGAH DENGAN GEOGRAPHICALLY WEIGHTED NEGATIVE BINOMIAL REGRESSION (GWNBR)
Authors: Suryani Indah , Yasin Hasbi , Kartikasari Puspita
Published: May 2021

Dengue Hemorrhagic Fever (DHF) is one of the diseases with unsual occurrence in Central Java and spread throughout the regency/city. The number sufferers of this disease is still high because the mortality rate is still above the national target. Regarding the less handling of DHF spread, it is necessary to make a plan by identify the factors that allegedly affect that case. Characteristics of data the DHF cases is count data, so this research is carried out using poisson regression. If in poisson regression there is overdispersion, it can be overcome using negative binomial regression. Meanwhile to see the spatial effect, we can use the Geographically Weighted Negative Binomial Regression (GWNBR) method. GWNBR modeling uses a fixed exponential kernel for weighting function. GWNBR is better at modeling the number of DHF cases because it has the smallest AIC value than poisson regression and negative binomial regression. The results of research with poisson regression obtained three variables that have a significant effect on dengue cases. For negative binomial regression, two variables have a significant effect on DHF cases. While the GWNBR method obtained two groups of districts/cities based on significant variables. The variables affecting the number of DHF cases in all districts/cities in Central Java are the percentage of healthy houses, the percentage of clean water quality, and the ratio of medical personnel.Keywords: DHF, GWNBR, Poisson Regression, Binomial Negative Regression, Fixed Exponential Kernel
METODE MODIFIED JACKKNIFE RIDGE REGRESSION DALAM PENANGANAN MULTIKOLINIERITAS (STUDI KASUS INDEKS PEMBANGUNAN MANUSIA DI JAWA TENGAH)
Authors: Arrasyid Arya Huda , Ispriyanti Dwi , Hoyyi Abdul
Published: May 2021

The human development index is a value where the value showed the measure of living standards comparison in a region. The Human Development Index is influenced by several factors, one of them is the education factor that is the average years of schooling and expected years of schooling. A statistical method to find the correlation between the independent variable and the dependent variable can be conducted using the linear regression method. Linear regression requires several assumptions, one of which is the multicollinearity assumption. If the multicollinearity assumption is not fulfilled, another alternative is needed to estimate the regression parameters. One method that can be used to estimate regression parameters is the ridge regression method with an ordinary ridge regression estimator. Ordinary ridge regression then developed more into several methods, such as generalized ridge regression, jackknife ridge regression, and modified jackknife ridge regression method. The generalized Ridge Regression method causes a reduction to variance in linear regression, while the jackknife ridge regression method is obtained by resampling jackknife process on the generalized ridge regression method. Modified jackknife ridge regression is a combination of generalized ridge regression and jackknife ridge regression method. In this journal, the three ridge regression methods will be compared based on the Mean Squared Error obtained in each method. The results of this study indicate that the jackknife ridge regression method has the smallest MSE value. Keywords: Generalized Ridge Regression, Jackknife Ridge Regression, Modified Jackknife Ridge Regression, Multicolinearity
MODERATING STRUCTURAL EQUATION MODELING DENGAN PARTIAL LEAST SQUARE PADA PEMODELAN PENERIMAAN DAN PENGGUNAAN DOMPET DIGITAL DI KOTA SEMARANG
Authors: Nisa Mukrimatun , Sudarno Sudarno , Sugito Sugito
Published: May 2021

Digital wallets (e-wallets) are a technology that provides a new perspective for the public on non-cash payments that are far more practical and secure in transactions. The purpose of this study is to determine the factors that influence the success or failure of implementing digital wallets (e-wallets) using the variant-based Structural Equation Modeling method (Partial Least Square). In this decade, an approach has been developed that allows the relationship between an independent variable to the dependent variable which is influenced by other latent variables called Moderating Structural Equation Modeling (MSEM), so this study uses MSEM by measuring it using the ping method. The results of the analysis show that the factors that influence acceptance defined as interest in using the technology are social influences, faciliating conditions and consumer habits. Meanwhile, the factors that influence the use of digital wallets which are defined as usage behavior are interest in use and conditions that facilitate. The use of digital wallets (e-wallets) is also indirectly influenced by social influences, conditions that facilitate and consumer habits. the factor of supporting facilities from the issuer of digital wallets (e-wallets) is a factor that affects directly and indirectly the use of digital wallets (e-wallets). Analysis of Moderating Structural Equation Modeling (MSEM) using the ping method results that experience does not affect the acceptance and use of digital wallets (e-wallets) as moderation Keywords: Acceptance and Use Model, Digital Wallet (E-wallet), Partial Least Square, Moderating Structural Equation Modeling.