bluuebunny/crossref_metadata_2025 huggingface dataset:
How I Treat Relapsed and/or Refractory Multiple Myeloma
Authors: Lee Hans , Cerchione Claudio
Published: September 2020

The expanding therapeutic landscape of relapsed and/or refractory multiple myeloma (RRMM) has contributed to significant improvements in patient outcomes. These have included combinations of proteasome inhibitors (PIs), immunomodulatory drugs (IMiDs), monoclonal antibodies (mAbs), histone deacetylase inhibitors, and/or alkylating agents. More recently, the approval of the first-in-class nuclear export inhibitor selinexor and the first-in-class B-cell maturation antigen (BCMA) antibody-drug conjugate (ADC) belantamab mafodotin has helped address the current unmet need in patients refractory to PI, IMiD, and anti-CD38 mAb directed therapy, otherwise known as triple class refractory myeloma. With the growing number of treatment options in the RRMM therapeutic landscape, the choice and sequencing of drugs and combinations has become increasingly complex. In this review we discuss our approach and considerations in the treatment of both early and late RRRM based on best available data and our clinical experience.
How I Manage Frontline Transplant-Ineligible Multiple Myeloma
Authors: Derudas Daniele , Capraro Francesca , Martinelli Giovanni , Cerchione Claudio
Published: September 2020

The Multiple Myeloma (MM) is a plasma cells hematological malignancy with a median age of 69 years at diagnosis. The autologous stem cell transplantation is the standard of care for this disease but less than half of newly diagnosed patients are assessed for this treatment due to comorbidities or complications of disease. The management of transplant ineligible MM patients is based on the balance safety and efficacy of the new available regimen and a careful assessment of the frailty status is mandatory to define the goals. In this review we discuss of the clinical dilemmas in the management and define how to manage them based on the evidence from clinical trials and “real life” experience.
Advancing Leukemia Diagnostics: Role of Next Generation Sequencing (NGS) in Acute Myeloid Leukemia
Authors: Haferlach Torsten
Published: September 2020

AML diagnostics, initially based solely on morphological evaluation, now relies on multiple disciplines to reach its full potential. Only by integrating the results of cytomorphology, cytochemistry, immunophenotyping, cytogenetics and molecular genetics it is possible to fulfil WHO classification and ELN prognostication systems. Especially molecular genetics has gained a lot of interest over the last decade, mainly through the introduction of next generation sequencing (NGS). NGS application ranges from the investigation of single genes and panels to even whole exomes, transcriptomes and genomes. In routine AML diagnostics panels are the preferred NGS methodology. Here, we will review the power and limitations of NGS in the context of diagnosis, prognosis and precision medicine. Due to high dimensionality, NGS data interpretation is challenging but it also offers a unique investigatory chance and the opportunity to apply data mining techniques such as artificial intelligence. We will also reflect on how the incorporation of the improved knowledge base into routine diagnostics can pave the way for better treatment and more cure in AML.
A Phase II Trial of Osimertinib as the First-Line Treatment of Non–Small Cell Lung Cancer Harboring Activating EGFR Mutations in Circulating Tumor DNA: LiquidLung-O-Cohort 1
Authors: Park Cheol-Kyu , Cho Hyun-Ju , Choi Yoo-Duk , Oh In-Jae , Kim Young-Chul
Published: September 2020

Purpose Osimertinib is a potent, irreversible third-generation epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor for both EGFR-activating and T790M resistant mutation. The treatment efficacy of osimertinib was assessed in previously untreated patients with metastatic non–small cell lung carcinoma (NSCLC) harboring activating EGFR mutations in circulating tumor DNA (ctDNA) as well as tumor DNA.Materials and Methods Patients with activating EGFR mutations in their tumor DNA underwent screening with ctDNA analysis using Mutyper and Cobas v2 assays. Enrolled subjects received osimertinib 80 mg, once daily. Primary endpoint was objective response rate (ORR) and secondary endpoints were ctDNA test sensitivity, progression-free survival (PFS), duration of response (DoR), and safety.Results Among 39 screened patients, 29 were ctDNA positive for activating EGFR mutations and 19 were enrolled (ex19del, n=11; L858R/L861Q, n=7; G719A, n=1). Median age was 70 and most patients had brain metastases (15/19, 79%). ctDNA test sensitivity for activating EGFR mutations was 74% using both methods and 62% (Mutyper) or 64% (Cobas v2) for individual methods. ORR was 68% (13/19), median PFS was 11.1 months (95% confidence interval [CI], 0.0 to 26.7), and median DoR was 17.6 months (95% CI, 3.5 to 31.7). ORR and median PFS were significantly superior with ex19del (91%; 21.9 months; 95% CI, 5.5 to 38.3) than with L858R/L861Q (43%; 5.1 months; 95% CI, 2.3 to 7.9). One patient discontinued the drug because of drug-related interstitial pneumonitis.Conclusion Osimertinib had favorable efficacy in the first-line treatment of metastatic NSCLC harboring activating EGFR mutations in ctDNA as well as tumor DNA.
On framings of links in 3-manifolds
Authors: Bakshi Rhea Palak , Ibarra Dionne , Montoya-Vega Gabriel , Przytycki Józef H. , Weeks Deborah
Published: September 2020

We show that the only way of changing the framing of a link by ambient isotopy in an oriented

$3$
-manifold is when the manifold has a properly embedded non-separating

$S^{2}$
. This change of framing is given by the Dirac trick, also known as the light bulb trick. The main tool we use is based on McCullough’s work on the mapping class groups of

$3$
-manifolds. We also relate our results to the theory of skein modules.
Recovering from Maastricht
Authors: Bénassy-Quéré Agnès
Published: September 2020

The euro area crisis was less a crisis of the euro than a crisis of the Maastricht doctrine. The latter was based on a triple ban: no monetization of fiscal deficits, no bail-out, no sovereign default. The euro architecture was also based on a strict division of tasks: the European Central Bank would stabilize prices in the euro area as a whole, whereas national governments would stabilize their own economies in case of idiosyncratic shocks. To make things even more dysfunctional, bank supervision remained under the competence of the member states. Although much has been done since the crisis to reform the Maastricht framework, there are still major flaws that weaken the single currency.
Fiscal and financial conditions for a stronger euro area
Authors: Constâncio Vítor
Published: September 2020

The euro is irreversible but it needs reform to address well-known design deficiencies and also new challenges. Although progress has been made, further steps are needed, the most important of which are: revision of the fiscal rules, establishing a central stabilisation capacity, and completing the banking union (especially a deposit insurance, a capital market union based around a common safe asset, and improved macroprudential policy). This article sets out the necessary reforms in these areas in detail.
Pelaksanaan Proses Peradilan Dan Pemenuhan Hak Dalam Perlindungan Hukum Bagi Anak ( Menurut UU No. 11 Tahun 2012 )
Authors: Muhammad Surya Adi Wibowo
Published: September 2020

The purpose of this study is to find how the judicial proceedings for violations of the proven to have committed a criminal justice and criminal justice be face to face with the process , and what of sanctions and the protection laws will be provided to hak-hak children according to statute number 11 years 2012 about the criminal justice systems . By using the method of juridical normative , hence writers can conclude: 1 .The judicial process given to children is: trial should be done behind closed doors and decisions are openly to the public , investigators , the public prosecutor , the judge and legal adviser in conducting its function as law enforcement officials by not using dress uniform or bertoga; single presided over by a magistrate a trial, The judge spirit keeps the matter hidden blast of judgment and by the son was of a judge that are specially emphasised in the program of a justice of the woman who man having knowledge of god on the issue on psychiatric; the implementation of the son of due to go on trial the match will be held on the day there is a special levy; in the process of the trial the children must be accompanied by central on the part of parents .Was not allowed to be was covered by the reporters before those who surrender decisions which are carried out by the prosecutor and judges , have to being read the report a social worker who had been given authority and a court of law to scrutinize the conduct and the condition of residents such a child . 2. Protection laws against children s rights had received the very criminal according to a system and criminal justice , as for him who is the son of in the hour of the detention and placed in an institution the deployment of the son of while ( LPKS ) and institutions for the special building the son of ( LPKA ) , the kid for cancer and asked to undergo an incident in which she prior to taking over leadership of nought of the fulfilment of rudimentary living in the treatment of health and human services by the officers , have been able to take education and training as well as coaching and provide assistance , and in conjunction with adequate in accordance with the regulations statute .
Rüzgar Türbinlerinde İşletme ve Bakım
Authors: ÖZTÜRK Harun Kemal
Published: September 2020

Enerji tüketimi nüfus artışı, sanayileşme ve konfor seviyesinin artmasına bağlı olarak artmaktadır. Diğer yandan, günümüzde enerji tüketiminin çok büyük kısmının sağlandığı fosil yakıtlar, iklim değişikliği ve çevresel kirliliğe neden olmaktadır. Bu nedenle de, yenilenebilir enerji kaynakları ön plana çıkmaktadır. Yenilenebilir enerji kaynakları içerisinde ise rüzgar enerjisi, ilk yatırım ve işletme maliyetleri göz önüne alındığında ön plana çıkmaktadır. Rüzgar türbinlerinde arızalar nedeni ile meydana gelebilecek duraksamalar yatırımcıların istemediği konular içerisinde yer almaktadır. Rüzgar türbinlerinin mekanik ve elektriksel aksamları göz önüne alındığında, en çok arızanın elektriksel aksamlardan kaynaklandığı ancak mekanik arızalar sırasındaki duraksamaların ise daha uzun süreler aldığı gözlemlenmiştir. Rüzgar türbinlerinde yapılacak bakım çalışmaları ile hem arızaların önüne geçilebilmekte hem de duraksama süreleri kısıtlanmaktadır. Bu çalışmada, rüzgar türbinlerinde meydana gelen arızaların nedenleri ile işletme ve bakım konuları ele alınmıştır.
Fotovoltaik (PV) Pompa Sisteminin Bileşenlerinin Hesabı
Authors: DEMİR Ahmet , ARSLAN F.mertkan , GÜNERHAN Hüseyin
Published: September 2020

Çalışma kapsamında, bir fotovoltaik (PV) pompa sisteminin optimum olarak boyutlandırılması için bir programlama algoritması oluşturulmuştur. Boyutlandırma algoritması, sistemdeki enerji dengesini temel alarak çalışmaktadır. Algoritma, hem akülü hem de aküsüz PV pompa sisteminin boyutlandırılması için uygun olarak modellenmiştir. Akü içeren PV pompa sistemleri için optimizasyon, aküye giren-çıkan enerjilerin dengesi ile iterasyon yöntemi kullanılarak gerçekleşmektedir. Akü içermeyen sistemler için optimizasyon, pompanın kullandığı enerjiyi karşılayabilecek PV panel alanının bulunmasını temel almaktadır. Çalışmada oluşturulan algoritma, Temmuz ayında Manisa-Salihli ilçesinde 1 hektarlık alanda mısır bitkisi için uygulanmıştır. Bitkinin sulanması için damlama sulama yöntemi kullanıldığı kabulü yapılmıştır. Ek olarak, kuyu için gerekli kabuller ve varsayımlar yapıldıktan sonra, pompaya gereken güç 1,5 kW ve debi 9,55 m³/h olarak hesaplamalara eklenmiştir. Sonuç olarak, sistemde akünün bulunması dahilinde toplam 23 adet PV panel gerekli iken, akünün olmaması durumunda 36 adet PV panel gerekli olduğu hesaplanmıştır. Gerekli akü miktarı ise 3 adet olarak bulunmuştur. Bu sonuçlara göre, sistem içerisinde akü kullanılması halinde, gerekli PV panel miktarının önemli ölçüde düşürüldüğü hesaplanmıştır. Ek olarak, bir diğer önemli sonuç ise, sistemde akü bulunmaması durumunda, PV panelin elde edebileceği potansiyel enerji miktarının yarısı israf edilmektedir. Ancak akü kullanılması durumunda ise, israf edilecek bu enerji aküler tarafından toplanarak, sistemin daha optimize edilebilir bir hal alması sağlanmaktadır.
Heranças da paisagem semiárida: Os Relevos Residuais de Alexandria-RN, Brasil
Authors: Henriques Diógenys da Silva , Souza Anny Catarina Nobre de , Souza Sergio Domiciano Gomes de , Souza Maria Losângela Martins de
Published: September 2020

O presente artigo objetiva discutir acerca dos relevos residuais do semiárido nordestino, enfocando um estudo de caso realizado no município de Alexandria no Alto Oeste Potiguar, Rio Grande do Norte, através do qual apresenta-se como heranças das feições geomorfológicas marcantes da paisagem semiárida do sertão do oeste potiguar nordestino. No tocante os procedimentos metodológicos, a pesquisa é sistematizada em duas etapas: gabinete – levantamento bibliográfico e geocartográfico – e campo – visita e reconhecimento da área em estudo. Consideramos assim os estudos teóricos de Ab’Saber (2003), Bertrand (2004), Lima et. al. (2009), Maia e Nascimento (2015; 2018), Souza e Oliveira (2002), além de interpretações cartográficas acerca das características geológico-geomorfológicas da área com base na CPRM (2005). Neste trabalho, verificamos a presença de relevos residuais predominantes, bem como extensas áreas de lajedos, que conferem uma paisagem exuberante no interior do sertão potiguar nordestino, de uma morfologia granítica, resultante do processo formativo de processos endógenos e exógenos, como resposta à constituição da paisagem como herança, sobretudo os inselbergs.
PARADA CARDIORRESPIRATÓRIA: AVALIAÇÃO TEÓRICA DAS CONDUTAS EMERGENCIAIS DE PESSOAS LEIGAS
Authors: Souza Reginaldo Pereira de , Zanin Luciane , Motta Rogério Heládio Lopes , Ramacciato Juliana Cama , Flório Flávia Martão
Published: September 2020

Objetivo: avaliar o conhecimento e condutas relatadas por leigos frente a uma situação de parada cardiorrespiratória (PCR) em vítima adulta, considerando a vigente diretriz da American Heart Association (2015). Métodos: Estudo quantitativo, transversal, de caráter descritivo. Amostra probabilística, com representatividade municipal, de 397 transeuntes respondeu questionário estruturado pré testado. Resultados: Os respondentes tinham idade média de 31,1 (±11,9) anos e a maioria possuía ensino médio completo e/ou ensino superior incompleto (71,8%). A identificação teórica da PCR foi respondida corretamente por 51,6% dos participantes e 41,8% acertaram sobre as ações mais importantes de Suporte Básico de Vida (SBV) no adulto. O local da compressão no tórax foi respondido corretamente por 72,8% embora a minoria tenha referido corretamente a profundidade (11,3%) e o número de compressões (9,8%). Conclusão: Os participantes possuem conhecimentos limitados sobre o SBV e uso do desfibrilador externo automático (DEA), e diante de uma situação real, poderiam comprometer o prognóstico das vítimas de PCR.
ORTAOKUL ÖĞRETMENLERİNİN ALGILARINA GÖRE OKUL MÜDÜRLERİNİN YÖNETİCİ YETERLİKLERİ İLE ÖĞRETMENLERİN PSİKOLOJİK DAYANIKLILIK DÜZEYLERİ ARASINDAKİ İLİŞKİ
Authors: ÖZTÜRK Kübra , ERDEM Mustafa
Published: September 2020

Bu araştırmada Samsun il merkezindeki Milli Eğitim Bakanlığına bağlı resmi ortaokullarda görev yapan öğretmenlere göre okul müdürlerinin yönetici yeterlikleri ile öğretmenlerin psikolojik dayanıklılık düzeyleri arasındaki ilişki belirlenmiştir. Araştırma ilişkisel tarama modelindedir. Araştırmanın hedef evrenini Samsun il merkezinde yer alan Atakum, Canik ve İlkadım ilçelerinde 2017-2018 eğitim öğretim yılında görev yapan 2168 öğretmen oluşturmaktadır. Araştırmanın örneklemini bu ilçelerdeki 401 öğretmen oluşturmaktadır. Araştırma verilerinin toplanmasında “Kişisel Bilgi Formu”, “Okul Müdürlerinin Yeterlikleri Ölçeği” ve “Psikolojik Dayanıklılık Ölçeği” kullanılmıştır. Okul müdürlerinin yönetici yeterlikleri ile öğretmenlerin psikolojik dayanıklılık düzeyleri arasındaki ilişkiyi bulmak için Pearson korelasyon analizi; cinsiyet, medeni durum, yöneticilik yapma, yaş değişkenleri için t-testi; kıdem ve alan değişkenlerinde ANOVA kullanılmıştır. Araştırma bulgularına bakıldığında, okul müdürleri yönetici olarak yeterli ve öğretmenler psikolojik olarak dayanıklıdır. Yönetici yeterliklerinde öğretmenler en az kavramsal yeterlik, en fazla teknik yeterlik alt boyutlarına katılmışlardır. Psikolojik dayanıklılıkta öğretmenler en az kontrol, en fazla meydan okuma alt boyutlarına katılmışlardır. Cinsiyet, kıdem, alan, medeni durum ve yöneticilik yapıp yapmama değişkenlerinde, yönetici yeterlikleri ve psikolojik dayanıklılığa ilişkin öğretmenlerin algıları anlamlı farklılık göstermemektedir. 41 yaş ve üstü öğretmenler, 40 yaş ve altı öğretmenlere göre psikolojik olarak daha kontrollü ve daha dayanıklıdır. Okul müdürlerinin yönetici yeterlikleri ile öğretmenlerin psikolojik dayanıklılık düzeyleri arasında anlamlı, pozitif ve düşük düzeyde bir ilişki vardır. En yüksek ilişki kendini adama ile yönetici yeterlikleri toplam ve alt boyutları arasında çıkmıştır. En yüksek ilişki kendini adama ile insancıl yeterlikler arasında çıkmıştır. En düşük ilişki meydan okuma, kontrol ile yönetici yeterlikleri toplam ve alt boyutları arasında çıkmıştır.
Ritual Slaughtering of Livestock in “Aluk Rambu Solo”:
Authors: Salurante Tony
Published: September 2020

Kebudayaan Indonesia sangat kaya dengan ritual keagamaan, menariknya salah satu kebudayaan yang usianya sangat tua adalah ritual pemotongan hewan, yang juga biasa dilakukan sejak zaman Abraham. Hampir semua tradisi dari berbagai dunia memiliki ritual kurban dengan memotong segala jenis hewan. Salah satu tradisi itu ada di Tana Toraja. Dalam penelitian ini penulis menyoroti suatu usaha untuk mengadopsi ritual mantunnu tedong untuk menjelaskan pemahaman orang percaya mengenai pengorbanan Kristus di atas kayu salib. Dalam tulisan meyakini adanya titik temu atau jembatan yang mampu menjelaskan ajaran Alkitab bagi orang-orang di Toraja sehingga mereka dapat memaknai ritual Rambu Solo beserta ritual pemotongan kerbau lebih alkitabiah.
Ceylalictus variegatus (Olivier) (Hymenoptera, Colletidae), espèce nouvelle pour l’Aquitaine (France)
Authors: Léglise Éric , Genoud David , Pauly Alain , Vereecken Nicolas J.
Published: September 2020

Ceylalictus variegatus (Olivier) (Hymenoptera, Colletidae), new species for Aquitaine (France)
Sphex funerarius Gussakovskij nouveau pour la Belgique (Hymenoptera, Sphecidae)
Authors: Barbier Yvan , Devalez Jelle
Published: September 2020

Sphex funerarius Gussakovskij new for Belgium (Hymenoptera, Sphecidae)
Observations en Loire-Atlantique (France) de Stenoria analis (Schaum) (Coleoptera, Meloidae), cleptoparasite de Colletes hederae Schmidt & Westrich (Hymenoptera, Colletidae)
Authors: Mahé Gilles
Published: September 2020

Observations in Loire-Atlantique (France) of Stenoria analis (Schaum) (Coleoptera, Meloidae), cleptoparasite of Colletes hederae Schmidt & Westrich (Hymenoptera, Colletidae). - In September 2007 the author observed in Loire-Atlantique (France) Stenoria analis Schaum during the mating, the egg-laying, the hatching of the triungulins (first instar larvae of the blister beetle). Pictures taken on the site of observations show how the triungulins cling to the males of Colletes hederae Schmidt & Westrich to reach the nest of their host bees where the larvae will complete their life cycle.
Dasypoda braccata Eversmann (Hymenoptera, Dasypodaidae), nouvelle espèce pour l’apidofaune italienne
Authors: Praz Christophe , Carron Gilles , Michez Denis
Published: September 2020

Dasypoda braccata Eversmann (Hymenoptera, Dasypodaidae), new species for the Italian apidofauna. - We detail the first Italian record of Dasypoda braccata Eversmann 1852 in the Val di Susa (Near Torino, Piemonte, Italy). This new occurrence shifts the occidental limit of this ponto-mediterranean species of several hundreds kilometres westwards. We describe the habitat and discuss the presence of this oriental species in the Alps. We compare the distribution of D. braccata with that of other insects that occur in the same region and exhibit a similar oriental distribution. This finding points out the entomological richness of this continental and xeric alpine valley.
Voice Controlled Wheelchair
Authors: Arsha M. S. , Raj A. Remya , Pooja S. R. , Manoj Rugma , Sabitha S. A. , Mohan Shimi
Published: September 2020

This paper is a design of Voice Controlled Wheel Chair for people who has any physical illness. Here Arduino, microcontroller and geetech voice recognition module are used to support the motion of the wheelchair. In order to provide the battery level, a battery level indicator is also provided. Based upon the direction specified in the commands, the Arduino will drive the 2 motors. People those who has disabilities with their hands, foot and lower body are unable to perform tasks on regular basis. So, there are many applications which help handicapped person to perform their tasks. The aim of this system to help people who cannot move properly without help others due to any physical illness or disabilities. Speech recognition technology will provide a new way of human interaction with machine.
HUBUNGAN KEKERABATAN TUMBUHAN FAMILI CUCURBITACEAE BERDASARKAN KARAKTER MORFOLOGI DI KABUPATEN PIDIE SEBAGAI SUMBER BELAJAR BOTANI TUMBUHAN TINGGI
Authors: Zuraida Zufahmi Ervina Dewi
Published: September 2020

Cucurbitaceae merupakan tumbuhan yang dapat tumbuh di daerah dataran tinggi maupun dataran rendah. Memiliki kandungan gizi yang tinggi dan serat buah yang halus sehingga mudah dicerna,Â  banyak digunakan sebagai obat tradisional sebagai anti diabetes, anti hipertensi, anti tumor, immunomodulasi, dan anti bakteri karena banyak mengandung nutrisi dan senyawa bioaktif seperti fenolat, flavonoid, vitamin (termasuk vitamin Î²-karoten, vitamin A, vitamin B2, Î±-tokoferol, vitamin C, dan vitaminE) ,asam amino, karbohidratdan mineral(terutamakalium), kandungan energirendah(sekitar 17 Kcal/100 glabusegar)dan serat dalam jumlah yang besar.Tujuan penelitian ini adalah untuk mengetahui hubungan kekerabatan jenis tumbuhan famili Cucurbitaceae berdasarkan karakter morfologi di Kabupaten Pidie. Penelitian dilaksanakan pada Juni-Agustus 2018 di Kabupeten Pidie, terdiri dari Kecamatan Pidie, Mila, Indrajaya, Peukan Baro, Mutiara, dan Tangse. Pengamatan morfologi dilakukan dengan mengamati organ batang, daun, bunga, buah dan biji. Analisis data dengan menggunakan software UPGMA NTSYS untuk memperoleh dendrogram hubungan kekerabatan.Hasil penelitian menunjukkan bahwa ditemukan 8 (delapan) jenis tumbuhan famili Cucurbitaceae terdiri dari Cucumis sativus (mentimun), Luffa acutangula (gambas/oyong), Ligenaria siceria (labu air), Cucurbita moschata (waluh), Sechium edule (labu siam), Citrullus vulgaris (semangka), Cucumis melo (melon), dan Momordica charantia (pare). Karakterisasi morfologi pada tumbuhan famili cucurbitaceae menunjukkan adanya variasi morfologi pada organ batang, daun, bunga, buah dan biji. Pada koefisien kemiripan 0.67, dendogram dibagi menjadi 4 (empat) kelompok. Kelompok 1 terdiri dari Cucumis sativus (mentimun), Luffa acutangula (gambas/oyong), Ligenaria siceria (labu air), dan Citrullus vulgaris (semangka). Kelompok 2 terdiri dari Cucurbita moschata (waluh) dan Cucumis melo (melon). Kelompok 3 terdiri dari Sechium edule (labu siam). Kelompok 4 terdiri dari Momordica charantia (pare).Kata kunci: Cucurbitaceae, Karakter Morfologi, Dendogram
KONSENTRASI DAN INTERVAL WAKTU APLIKASI POC POMI TERHADAP PERTUMBUHAN DAN PRODUKSI TANAMAN JAGUNG MANIS (Zea mays saccarata. L.)
Authors: Intan Munawarah Budi Al Hadi, Jamilah,
Published: September 2020

Tujuan dari penelitian adalah untuk mengetahui pengaruh konsentrasi dan interval waktu pemberian pupuk cair POMI terhadap pertumbuhan dan produksi tanaman jagung manis. Penelitian dilaksanakan di kebun percobaan Fakultas Pertanian Universitas Jabal Ghafur Sigli, dari Januari sampai Maret 2017. Bahan yang digunakan adalah benih jagung manis varietas Bonanza F-1, pupuk organik cair POMI, pupuk NPK, air serta kelengkapan lain dalam menunjang penelitian. Penelitian ini menggunakan Rancangan Acak Kelompok pola faktorial. Ada 2 faktor yang diteliti yaitu faktor sistem konsentrasi (K) 3 taraf; K1 = 2,5 ml/ liter air/plot, K2 = 5 ml/ liter air/plot, K3 = 7,5 ml/  liter air/plot dan faktor interval waktu pemberian pupuk (I) 3 taraf; I1 =  7 HST, I2 =  22 HST, I3 = 32 HST. Hasil penelitian menunjukkan, kosentrasi POMI berpengaruh sangat nyata terhadap parameter tinggi tanaman umur 32 HST dan panjang tongkol per sampel, berpengaruh nyata terhadap lebar daun  umur 32 HST dan berat tongkol per plot, tidak berpengaruh nyata terhadap tinggi tanaman  umur 7 HST dan 22 HST, lebar daun umur 7 HST dan 22 HST. Perlakuan terbaik dijumpai pada dosis pemberian 7,5 ml/liter (K3). Interval POMI berpengaruh sangat nyata terhadap parameter tinggi tanaman umur 22 HST, berat tongkol per plot dan panjang tongkol per sampel serta berpengaruh nyata terhadap lebar daun umur 22 dan 32 HST. Perlakuan terbaik dijumpai pada (I2) Interval POMI 22 HST. Kata kunci: jagung, interval waktu, konsentrasi POMI
POTENSI BAHAN-BAHAN HAYATI SEBAGAI SUMBER ZAT PENGATUR TUMBUH (ZPT) ALAMI
Authors: Emilda Emilda,
Published: September 2020

Pertanian organik makin diminati karena kecenderungan masyarakat untuk hidup sehat, termasuk di masa pandemi Covid 19 saat ini. Salah satu ciri pertanian organik adalah menghindari penggunaan zat pengatur tumbuh (growth regulator) sintetis. Bahan-bahan hayati dari tumbuhan dan hewan diketahui memiliki potensi sebagai sumber ZPT alami. Tujuan penulisan artikel ini adalah untuk menjelaskan potensi beberapa bahan hayati sebagai ZPT alami dan mengetahui senyawa ZPT yang terkandung didalamnya. Sedangkan metode yang digunakan adalah kajian kepustakaan. Berdasarkan sejumlah hasil penelitian yang dikaji diketahui bahwa ekstrak bawang merah, air kelapa, ekstrak tauge (kecambah kacang hijau) serta ekstrak dari hewan moluska memiliki potensi sebagai ZPT alami. Ekstrak bawang merah, tauge dan hewan-hewan moluska mengandung auksin yang dapat memacu pertumbuhan akar, tunas dan bibit. Sedang air kelapa mengandung auksin, berbagai sitokinin, giberelin dan asam absisat. Hanya saja pengaplikasiannya belum mencapai hasil yang optimal, sehingga perlu penelitian lebih lanjut untuk pengembangan.Kata kunci: ZPT alami, ekstrak bawang merah, air kelapa, auksin, sitokinin
PENERAPAN METODE PROBLEM SOLVING UNTUK MENINGKATKAN PRESTASI BELAJAR SISWA KELAS XI-MIA2 POKOK BAHASAN DINAMIKA PERAN INDONESIA DALAM PERDAMAIAN DUNIA PADA SMA NEGERI 1 KEMBANG TANJONG
Authors: Suryani Lilis,
Published: September 2020

Penelitian ini dilakukan di SMA Negeri 1 Kembang Tanjong selama tiga bulan sejak bulan Februari sampai April 2019 bertujuan untuk meningkatkan prestasi belajar siswa kelas XI-MIA2 pokok bahasan dinamika peran Indonesia dalam perdamaian dunia melalui penerapan metode problem solving pada SMA Negeri 1 Kembang Tanjong. Metode penelitian yang digunakan adalah penelitian tindakan kelas yang terdiri dari 2 siklus. Subjek penelitian adalah siswa-siswiKelas XI-MIA2 SMA Negeri 1 kembang Tanjong tahu pelajaran 2018/2019 sebanyak 21 orang. Analisis data menggunakan teknik analisis deskriptif komparatif dengan membandingkan kondisi awal dengan hasil-hasil yang dicapai pada setiap siklus, dan analisis deskriptif kualitatif hasil observasi dengan membandingkan hasil observasi dan refleksi pada siklus I dan siklus II. Persentase ketuntasan yang diperoleh pada siklus I sebesar 61,9% dengan nilai rata-rata kelas sebesar 68,6 dan meningkat pada siklus II menjadi 90,5% dengan nilai rata-rata kelas 78,1. Pada kedua siklus ini terjadi perubahan aktivitas dan perolehan nilai yang signifikan bila dibandingkan dengan pra siklus dengan ketuntasa belajar yang hanya mencapai 42,9% dan nilai rata-rata adalah 61,4. Dengan demikian, melalui penerapan metode problem solving dapat meningkatkan prestasi belajar siswa kelas XI-MIA2 pada pokok bahasan dinamika peran Indonesia dalam perdamaian dunia pada SMA Negeri 1 Kembang Tanjong Kata Kunci : Prestasi Belajar, Metode Problem Solving, Dinamika Peran Indonesia dalam Perdamaian Dunia
THE EFFECT OF USING ENGLISH SONGS ON THE STUDENTS’ SPEAKING SKILL
Authors: Nora Vita Mustakim Sagita, Ramlan,
Published: September 2020

The objective of the study was to get the empirical data about the effect of using song on students’ speaking skill at the second year students of SMP Negeri 1 Mila, Pidie. The method of this study was quantitative method. To get the sample, researcher used random sampling as the technique. The sample of this study were class VIII.B as the experimental class and VIII.A as the control class. Both of the class were consisted of 22 students. In collecting the data, the researcher conducted pre test and post test by asking students singing songs. In the control class, the result of pre test(x1) score was 1285. The result of post test(x2) score was 1462. The gained(dx) both of pre test and post test was 182. The mean(Mx) score was 8,2. in the experimental class, the result of pre test(y1) score was 1190. The result of post test(y2) score was 1608. The gained(dy) both of pre test and post test was 418. The mean(My) score was 19. The testing of hypothesis was analyzed using t-test formula. The result ttest (t0) both of the classes was 3,14. The result of this study showed that there was significant difference on students’ speaking skill that was taught by using English song. In the table of significance, it could be seen on the significance degree or ? = 0.05 and df=42. The ttable (t095(42))=2,68. Then, by comparing the result t0 is bigger than ttable, that is 3.14 2,68. The hypothesis (Ha)  was accepted and the null hypothesis (Ho) was rejected. It can be concluded that the using of English song was effective in teaching speaking.Key words: Speaking, English song.
MENINGKATKAN MOTIVASI BELAJAR SISWA KELAS XI-B1 SMK-PP NEGERI SAREE MELALUI PENDEKATAN MATEMATIKA REALISTIK
Authors: Yustina Yustina
Published: September 2020

Yustina (2014). Improving Learning Motivation of Students in XI-B1 SMK-PP Negeri Saree through Realistic Mathematics Education.

This study aims to analyse the improvemet of studentsâ€™ motivation and to describe the activities of students during Math class using realistic mathematics education. This study is classroom action reasearch. It was conducted in XI-B1 SMK-PP Negeri Saree school year 2013/2014 within 22 pupils that were consisted of 13 boys and 9 girls. This study was done in two cycles. The result of study in cycle I showed that only 4 students (18%) achieved the comprehensiveness. On the other hand, in cycle II, 20 students (91%) completed the target grade. The enhancement of studentsâ€™ motivation can be seen from studentsâ€™ comment from one through five statements. In the first statement, 12 students (55%) responded strongly agree with the learning process, 8 students (36%) agree, and 2 students (9%) concerned doubtful. Second statement showed that 14 students (64%) were strongly agree with the learning approachment, 6 students (27%) were agree, and only 2 students (9%) were doubtful. From statement 3, 6 students (27%) responded with strongly agree, 2 students (9%) agree, 4 students (14%) doubthful and 2 students (9%) responded not agree. In the fourth statement, 11 students (50%) said strongly agree with the lesson taught, 10 students (46%) commented agree, and only one student (4%) was doubtful. Statement five, indicated that 11 students (50%) stated strongly agree with the class and the other 11 students (50%) voted agree. Based on study data analysis result, it can be concluded that the implementation of realistic mathematic education is able to improve studentsâ€™ motivation in class XI-B1 of SMK-PP Negeri Saree.

Key words : Learning with Realistic Mathematics Education, Motivation of Students, Activities of Student
PENGARUH TEKNOLOGI BUDIDAYA DAN DOSIS PEMUPUKAN NPK TERHADAP SIFAT KIMIA TANAH DAN PRODUKSI PADI SAWAH (Oryza sativa L.)
Authors: Sufardi Fajri Andria Syah Putra
Published: September 2020

The objectives of this research aimed to study effects of cultivation technology and appropriate dosages of NPK on Characteristics of Soil Chemistry and rice product. The experiment was arranged in a factorial split plot design with three replicates. Factor of cultivation technology consisted of four levels, i.e. legowo system cultivating, conventional system cultivating, salibu technology, and ratooning technology. Factor of appropriate dosages of NPK consisted of three levels i.e. 100 kgs ha-1 NPK Phonska, 200 kgs ha-1 NPK Phonska, 300 kgs ha-1 NPK Phonska. The result showed that cultivation technology exerted higgly significant effect on N-total, pH (H2O), KTK, Câ€“organic, weight of 1000 grains, numbers of productive tillers, yields, and exert a significant effect on Kdd. Appropriate dosages of NPK exerted highly significant effects on yields and exerted a significant effect on N-total and numbers of productive tillers. Interaction between cultivation technology and appropriate dosages of NPKshowed highly significant on N-total, numbers of production tillers and yields. The highest yields of rice showed by cultivation technologylegowo system with appropriate dosages of 300 kgs ha-1 NPK Phonska, however based on financial analysis cultivation technology of salibu turned out the best of other cultivation technology since it required minimum cost.
Kekerasan terhadap Perempuan dalam Novel Bidadari Hitam Karya T.I. Thamrin
Authors: Fitriani Dewi
Published: September 2020

Penelitian ini bertujuan mendeskripsikan dan menganalisis bentuk kekerasan terhadap tokoh perempuan dalam novel Bidadari Hitam karya T.I. Thamrin. Pendekatan yang digunakan adalah pendekatan kualitatif dengan metode deskriptif analisis. Sumber data adalah novel Bidadari Hitam karya T.I. Thamrin. Data yang dijadikan objek dalam penelitian ini adalah kata-kata, kalimat, dan dialog pada sumber data yang mendeskripsikan bentuk-bentuk kekerasan yang dialami tokoh perempuan. Teknik analisis yang digunakan adalah teknik deskriptif kualitatif. Hasil penelitian menunjukkan bahwa bentuk-bentuk kekerasan terhadap perempuan dalam novel Bidadari Hitam karya T.I.Thamrin adalah kekerasan fisik, kekerasan psikis, kekerasan seksual, dan kekerasan ekonomi. Dengan demikian, dapat disimpulkan bahwa kekerasan terhadap perempuan terjadi berulang- ulang pada korban dan keluarganya sehingga mengakibatkan penderitaan dan kesengsaraan yang berkepanjangan. Di samping itu, konflik bersenjata yang terjadi di Aceh pada tahun 1989-2001 menambah kuantitas kekerasan yang dilakukan oleh aparat keamanan (TNI/POLRI), GAM (Gerakan Aceh Merdeka), dan warga sipil. Semua kekerasan tersebut tidak dapat diterima oleh tokoh-tokoh perempuan baik secara psikis maupun batin.

Kata kunci: Kekerasan, Perempuan, Novel
Pola Pembinaan Prestasi Olahraga Usia Dini Pada SD Negeri 2 Percontohan Tijue
Authors: Amirzan Amirzan
Published: September 2020

Dukungan seluruh unsur yang terkait dalam pengembangan prestasi siswa di sekolah dipandang sebagai suatu hal yang sangat penting dalam program peningkatan prestasi olahraga usia dini di sekolah, dengan penyelenggaraan pembelajaran PJOKyang berfungsi untuk mengembangkan potensi fisik siswa yang mengarah kepada pembinaan aspek psikomotor, karena semua akan bermuara dan bermanfaat bagi siswa untuk mengembangkan potensi kemampuan berolahraga yang ia miliki. Penelitian yang berjudul Pola Pembinaan Prestasi Olahraga Usia Dini Pada SD Negeri 2 Percontohan Tijue bertujuan untuk mengetahui bagaimana sistem pembinaan prestasi olahraga usia dini di sekolah, dan bagaimana peran guru bidang studi, karyawan dan Kepala Sekolah dalam membina prestasi olahraga di sekolah. Penelitian yang menentukan sampel Kepala Sekolah, wakil kepala sekolah Guru PJOK, Guru Kelas, karyawan dan siswa sebanyak 25 orang.Sedangkan isntrumen penelitian dengan mengedarkan angket.Bedasarkan bukti-bukti yang telah dikumpulkan bahwa Pembinaan prestasi olahraga usia dini di SD Negeri 2 Percontohan Tijue dilaksanakan dengan kegiatan pembinaan yang terprogram, didukung oleh guru PJOK yang memenuhi keriteria kelayakan, mendapat persetujuan dari semua guru kelas yang ada, kegiatan pembinaan dibiayai seluruhnya oleh sekolah dan wali siswa, kepala sekolah membina dengan baik, hasil penelitian membuktikan bahwa pembinaan cabang olahraga telah berjalan sebagai mana mestinya.

Kata Kunci : Prestasi, Olahraga, Usia dini
PENGARUH IMBALAN, PENGAWASAN, KONDISI KERJA, PENGEMBANGAN KARIER, PENGHARGAAN DAN KELOMPOK KERJA TERHADAP KEPUASAN KERJA PERAWAT PELAKSANA DI RUANG RAWAT INAP RUMAH SAKIT UMUM DAERAH TGK.CHIK DITIRO SIGLI
Authors: Yuanita Tristi
Published: September 2020

Job satisfaction of nurses is an important aspect that needs to get the attention of the hospital in an effort to improve services to patients. If the job satisfaction of nurses are met, then the nurse will tend to have high motivation to work, otherwise if would lead to lower job satisfaction, absenteeism, strikes and other acts that harm the hospital. This study aims to examine the effect of compensation, supervision, working conditions, career development, rewards, and the working group on job satisfaction.

This study used cross sectional design with quantitative approach in the General Hospital of TGK. Chik Ditiro Sigli in September and October 2015. The sample amounted to 57 nurses, using a questionnaire. Data analysis methods are univariate, bivariate and multivariate by using multiple linear regression.

The results showed that in exchange, supervision, working conditions, rewards, working groups, no significant effect on job satisfaction. While the career development of a significant effect on job satisfaction. Influential variable is the most dominant career development.

Suggested to the leadership of the hospital to provide an opportunity for nurses to improve education, allocation of funds for training, draw up a clear policy for the promotion and provision of equal opportunities to nurses for structural positions.
Pengaruh Implementasi SistemPengembangan Sumberdaya Manusia Terhadap Kinerja Karyawan (Studi Kasus Pada Biro Rektorat Universitas Jabal Ghafur)
Authors: Abdullah Husaini
Published: September 2020

Penelitian ini bertujuan untuk Mengetahui â€œManajemen, Judul: â€œPengaruh Implementasi Sistem Pengembangan Sumberdaya Manusia Terhadap Kinerja Karyawan (Studi Kasus Pada Biro Rektorat Universitas Jabal Ghafurâ€.Dimana variabel independen yaitu Pendidikan, Pelatihan dan Kinerja Karyawan (Y) sebagai variabel dependennya.Populasi dalam penelitian ini adalahsemua karyawan Biro Rektorat Universitas Jabal Ghafur sebanyak 55 Orang Karyawan.Sampel diambil menggunakan total sample yaitu seluruh populasi di jadikan sampel.Sampel penelitian ini sebanyak 55 Orang.Data yang dihimpun dalam penelitian ini terdiri dari data primer dan data sekunder, baik data kualitatif maupun data kuantitatifdan melalui kuesioner yang diisi oleh responden.Kemudian data yang diperoleh dianalisis dengan menggunakan analisis regresi berganda. Analisis ini meliputi Uji Normalitas, Uji Multikolinearitas, Uji HeterokedastisitasUji Asumsi Klasik, Uji Hipotesis melalui Uji F dan Uji t, serta analisis Koefisien Determinasi (RÂ²). Berdasarkan hasil penelitian, diperoleh persamaan regresi:Y = 1,070 + 0,362 X1 + 0,390 X2. Hasil analisis diatas dapat disimpulkan bahwa berdasarkan uji t diketahui bahwa Variabel Pendidikan berpengaruh secara positif dan signifikan terhadap Kinerja Karyawan Biro Rektorat Universitas Jabal Ghafur. Hal ini terlihat dari nilai signifikan (0,000) lebih kecil dari 0,05 dan nilai thitung 4,292 > ttabel 2,006, Variabel Pelatihan berpengaruh secara positif dan signifikan terhadap Kinerja Karyawan Biro Rektorat Universitas Jabal Ghafur. Hal ini terlihat dari nilai signifikan (0,000) lebih kecil dari 0,05 dan nilai thitung 4,550 > ttabel 2,006. Berdasarkan perhitungan koefisien determinasi (R2), menunjukkan bahwa Angka Adjusted R2 atau determinan sebesar 0,681 berarti 68.1% faktor-faktor kinerja karyawan dapat dijelaskan oleh Pendidikan (X1), Pelatihan (X2), sedangkan sisanya 31,9% dapat dijelaskan oleh faktor-faktor lain yang tidak diteliti dalam penelitian ini.

Kata kunci: Implementasi Sistem, Pengembangan Sumber Daya Manusia, Kinerja Karyawan
KINERJA DOSEN DALAM PENGEMBANGAN BUDAYA AKADEMIK PADA SEKOLAH TINGGI ILMU TARBIYAH AL-HILAL SIGLI
Authors: Mustakim Sagita Muhammad Iqbal
Published: September 2020

Sekolah Tinggi Ilmu Tarbiyah Al-Hilal Sigli merupakan suatu lembaga pendidikan tinggi dan pusat kajian strategis ilmu pengetahuan Agama Islam, membutuhkan tenaga dosen yang memiliki kemampuan dan kinerja yang handal. Penelitian ini bertujuan untuk mengetahui kinerja dosen pada SekolahTinggiIlmuTarbiyah Al-Hilal Sigli. Penelitian ini menggunakan pendekatan deskriptif dan metode kualitatif dengan teknik pengumpulan data dokumentasi, observasi dan wawancara. Subjek penelitian para ketua sekolah tinggi, ketua prodi, dosen, kepala tata usaha, dan mahasiswa. Analisis data dilakukan dengan cara: reduksi data, penyajian data, dan penarikan kesimpulan. Penelitian ini menunjukkan bahwa: 1) Kinerja dosen dalam melaksanakan proses perkuliahan telah mengikuti prinsip-prinsip pembelajaran, hal ini dilihat dari perencanaan, pelaksanaan dan evaluasi perkuliahan yang dilaksanakan oleh dosen. 2) Motivasi dosen dalam melaksanakan perkuliahan tercermin pada kemauan dan kesadaran dosen dalam melaksakan tugas-tugas yang diembankan kepadanya.

Kata kunci : Kinerja, Dosen, Akademik.
PELAKSANAAN SUPERVISI AKADEMIK PENGAWAS SEKOLAH SEBAGAI UPAYA PENINGKATAN PROFESIONALISME GURUDI SDN ANTARA
Authors: Marsalin Marsalin
Published: September 2020

Academic supervision is an activity planned to help teachers in the learning process in order to improve studentsâ€™ learning outcomes. This study aimed at investigating the supervision of schoolâ€™s supervisor in improving the professionalism of teachers and improve the quality of education at SD Negeri Antara. The type of this research is qualitative and the data were obtained by observation, documentation and interview. The results of this study (1) supervision conducted by applying the official approach, partners, and kinship, and the techniques developed by supervisors in implementing academic supervision vary considerably;

(2)supervisory obstacles in carrying out academic supervision is the number of teachers were too many, however it only had limited time; (3) the implementation of general academic supervision is good enough and able to carry out its duties and functions properly; (4) aspects that have been targeted by the supervision of schoolâ€™s supervisors are still limited, not all aspects of academic supervision; (5) the frequency of visits by schoolâ€™s supervisors in conducting academic supervision is considered lack because it is not evenly distributed; teachers receive class visits by supervisors; and (6) efforts made by supervisors in carrying out academic supervision at SD Negeri Antara have not been optimal in providing guidance to teachers.

Keywords: Academic Supervision; Schoolâ€™s Supervisor; Teachersâ€™ Profesionalism
PERAN ORANG TUA TUNGGAL (IBU) DALAM MENGEMBANGKAN MORALITAS ANAK DI KELURAHAN TLOGO MULYO KECAMATAN PEDURUNGAN SEMARANG
Authors: Nurdiana Nurdiana
Published: September 2020

Keutuhan sebuah keluarga (ayah, ibu, anak) merupakan salah satu faktor dalam menguatkan moral anak, hal ini akan berbeda bila keluarga tidak utuh atau single parent, dalam hal ini bagi orang tua tunggal (ibu) dalam mengembangkan moralitas anak. Penelitian ini bertujuan untuk menganalisis bagaimana bentuk keluarga fungsional dari orang tua tunggal (ibu), Menganalisis hasil dari penanaman pengetahuan moral, perasaan moral, dan mewujudkan tindakan moral bagi anak yang memiliki orang tua tunggal(ibu) dalam mengembangkan moralitas anak. Metode penelitian yang digunakan metode kualitatif. Hasil penelitian menunjukkan meskipun orang tua tunggal (ibu)memiliki kesibukan dalam mencari nafkah akan tetapi orang tua tunggal (ibu) bisa membagi waktunya dalam membimbing,memantau dan mengarahkan tumbuh kembang anak dan mampu memberikan putra-putrinya pendidikan formal,informal dan nonformal. Orang tua tunggal (ibu) bisa menanamkan pengetahuan moral, perasaan moral dan mewujudkan tindakan moral bagi anak-anaknya.

Kata kunci: Single Parent, Moralitas Anak
PENERAPAN METODE TGT (TEAM GAME TOURNAMENT) MENINGKATKAN HASIL BELAJAR BAHASA INGGRIS PADA SISWA KELAS VIII DI SMP NEGERI 1 BANDAR BARU
Authors: Nasruddin Nasruddin
Published: September 2020

This study aims to determine the increase in learning motivation which in turn will improve student learning outcomes in learning Class VIII English with the application of TGT (Team Game Tournament) on the self-test unit material at Bandar Baru 1 Junior High School, second semester 2015/2016 academic year .This type of research includes action research. The subjects of this study were Class VIII students at SMP Negeri 1 Bandar Baru. The results of this study indicate: Through the results of classroom action research at SMP Negeri 1 Bandar Baru there was an increase in learning motivation, namely in the first cycle the average was 68.10 while in the second cycle was 80.00. Before learning with the TGT (Team Game Tournament) Method, the student score is 60.71. In the first cycle, the results of student evaluations in the eyes of English Language Subjects The self-test unit gets an average score of 70.00, while in the second cycle it gets an average score of 80.00. From the study there was an increase in learning completeness as much as in the first cycle of 33% and in the second cycle by 95%. Thus, it can be concluded that the implementation of classroom action research through the TGT (Team Game Tournament) Method of learning English in the material The self-test unit can increase learning motivation which by itself can improve learning outcomes for Class VIII students at SMP Negeri 1 Bandar Baru.

Keywords: TGT Method (Game Tournament Team), Learning Outcomes