bluuebunny/crossref_metadata_2025 huggingface dataset:
Study on the Effect of Different Endoscopic Auxiliary Treatment of Gastric Mucosal Microtumor
Authors: Zhong Xiongping , Wang Fuqun , Zeng Dehui , Chen Yijin , Wang Shengbing
Published: October 2022

Objective. To explore the effect of endoscopy in the treatment of gastric mucosal microtumors. Methods. A total of 229 patients with gastric mucosal microtumors were treated in our hospital from January 2016 to December 2021. All patients were divided into three groups group A, group B, and group C. Group A was treated with a transparent cap combined with circle-assisted endoscopic resection, group B with ligator combined with circle-assisted endoscopic resection, and group C with endoscopic mucosal tumor resection. The effects of the three groups were observed. Results. There were 47 patients in group A, 17 males, and 30 females, aged 36–69 years, with an average age of 55.6 ± 9.2 years. There were 54 patients in group B, 18 males, and 36 females, aged 38–72 years, with an average age of 57.6 ± 7.7 years. There were 128 patients in group C, 29 males, and 99 females, aged 33–78 years, with an average age of 55.6 ± 8.4 years. There is no significant difference in age and sex between group A, group B, and group C (

P
>
0.05

). The incidence of postoperative complications in group B (66.7%) was significantly higher than that in group A (57.4%) and group C (53.9%) (all

P
<
0.05

). The incidence of postoperative complications in group A (57.4%) was higher than that in group C (53.9%), and the difference was statistically significant (

P
<
0.05

). Conclusion. Endoscopic mucosal resection and ligation combined with circle-assisted endoscopic resection are effective and safe in the treatment of gastric mucosal microtumors, but it needs to be combined with targeted nursing measures. The transparent cap combined with ring-assisted endoscopic resection has a significant effect on the treatment of gastric mucosal micromasses, reducing operative complications.
An Empirical Analysis of Social Interaction in Online Teaching in Open Universities Based on Flipped Classroom
Authors: Wang Xinjie , Yuan Ding
Published: October 2022

As a teaching model, flipped classroom can stimulate students’ learning interests and promote students’ positive social interactions. As an adult university relying on information technology to carry out online teaching, open universities need to pay attention to the online learning quality of adult students. This study attempts to apply the concept of flipped classroom to online teaching in open universities. While exploring the feasibility of the online flipped classroom teaching model, it adopts an equal group experiment method, content analysis method, and social network analysis method to compare the social interaction level difference between online teaching based on flipped classroom and conventional online teaching. The results show that online flipped classroom has a positive and significant impact on student’s cognitive processing level and knowledge construction level and can promote groups to form complex knowledge network forms. This shows that network teaching based on flipped classroom can exercise students’ high-order thinking ability, enhance students’ cooperative consciousness and behavior, and stimulate students’ subjectivity in learning. The purpose of this study is to provide references for promoting interactive behavior and quality in online teaching.
Mittag-Leffler Stability and Attractiveness of Pseudo Almost Periodic Solutions for Delayed Cellular Neural Networks
Authors: Eidinejad Zahra , Saadati Reza , Repovš Dušan D.
Published: October 2022

We consider a class of nonautonomous cellular neural networks (CNNs) with mixed delays, to study the solutions of these systems which are type pseudo almost periodicity. Using general measure theory and the Mittag-Leffler function, we obtain the existence of unique solutions for cellular neural equations and investigate the Mittag-Leffler stability and attractiveness of pseudo almost periodic functions. We also present numerical examples to illustrate the application of our results.
[Retracted] The Burden of Psoriasis in China and Global Level from 1990 to 2019: A Systematic Analysis from the Global Burden of Disease Study 2019
Authors: Liu Simin , Yan Zhangren , Liu Qiao
Published: October 2022

Objectives. Psoriasis is a skin disease thought to be related to immune system dysfunction. Our study is aimed at analyzing the prevalence of psoriasis in China in multiple different categories and compared the prevalence at the global level, in order to bring insights to policymakers for treating this disease. Methods. We analyzed psoriasis trends from 1990 to 2019 in China as well as around the globe with data from the Global Burden of Disease 2019 study. Multiple metrics such as age‐standardized prevalence rates, percent change in age‐standardized prevalence rates, disability‐adjusted life years (DALYs), and age and sex patterns were included. We also predicted the trends of psoriasis prevalence and DALYs in the following 30 years. Results. In China, the age‐specific prevalence cases showed a right shift in 2019 compared to 1990 with a peak between the ages of 50 and 54 years and an obvious surpass in males between 40 and 69. Though China still had the largest number of psoriasis cases in 2019, the increase rate was below global level. A positive linear relationship between psoriasis prevalence and comorbidities was seen with rheumatoid arthritis, diabetes mellitus, multiple sclerosis, nonrheumatic valvular heart disease, cardiomyopathy and myocarditis, nonmelanoma skin cancer, non‐Hodgkin lymphoma, and multiple myeloma in China within the male group in 2019. Discussion. The burden of psoriasis, as measured by the absolute number of DALYs, continues to increase around the world. The scarcity of modifiable risks for most psoriasis burdens suggests that new knowledge is needed to develop effective prevention and treatment strategies.
Comprehensive Analysis and Validation of Solute Carrier Family 25 (SLC25) and Its Correlation with Immune Infiltration in Pan‐Cancer
Authors: Liu Ao-ran , Liu Ying-nan , Shen Shi-xuan , Yan Li-rong , Lv Zhi , Ding Han-xi , Wang Ang , Yuan Yuan , Xu Qian
Published: October 2022

As the largest gene family functioning in protein transport among human solute carriers, the SLC25 family (mitochondrial carrier family) can participate in development of cancer. However, a comprehensive exploration for the exactly roles of SLC family remains lacking. In the present study, a total of 15 functional SLC25 family genes were retrieved from all current publications. And multidimensional analyses were systematically performed based on the transcriptome and genome data of SLC25 family from a variety of online databases for their expression, immune cell infiltration, and cancer prognosis. Validation by qPCR and immunohistochemistry were further conducted for the expression of partial SLC25 family members in some tumor tissue. We found that the SLC25 family had strong correlation with immune cells, such as macrophages M2, CD8+ T cell, CD4+ T cell memory activated, and memory resting. Among them, SLC25A6 was most correlated with Macrophage M1 in uveal melanoma (r = −0.68, P = 1.9e − 0.5). Expression of mRNA level showed that SLC25A4 was downregulated in stomach adenocarcinoma and colon adenocarcinoma. SLC25A7 was highly expressed in stomach adenocarcinoma and colon adenocarcinoma. SLC25A23 was decreased in colon adenocarcinoma. qPCR and immunohistochemistry validation results were consistent with our bioinformatics prediction. SLC25A8 was associated with the prognosis of cancer. All these findings suggested that the SLC25 family might affects the immune microenvironment of the cancer and then had the potential to be predictive biomarkers for early diagnosis and prognosis as well as novel targets for individualized treatment of cancer.
Meta-Analysis of Different Acupuncture Points in the Treatment of Ankylosing Spondylitis with Supervised Moxibustion
Authors: Cheng Jie , Wang Xinyi , Wang Leisheng , Zhang Yufei , Gu Yu , Mao Dan , Zhou Xingyu , Wang Xiaolong , Tian Yuansheng
Published: October 2022

Objective. To investigate the clinical efficacy of different acupuncture points in the treatment of ankylosing spondylitis with supervised moxibustion. Methods. Retrospective analysis of 61 AS patients (diagnosed as ankylosing spondylitis of kidney-yang deficiency type by Chinese medicine) admitted to our hospital from January 2020 to February 2021, randomly divided into 30 cases in the experimental group (Du moxibustion + basic western medicine treatment) and 31 cases in the control group (basic western medicine treatment alone). The changes in quantitative scores of the main symptoms and major signs (thoracic mobility, occipital-wall distance, finger-ground distance, and laboratory index (ESR)) were analyzed before and after treatment. Results. Of the 30 cases in the experimental group, 2 were clinically cured, 3 were apparently effective, 21 were effective, and 4 were ineffective, with an overall effective rate of 86.7%; of the 31 cases in the control group, 1 was clinically cured, 1 was apparently effective, 1 was effective. 24 were effective, and 5 were ineffective, with an overall effective rate of 83.9%. Comparing the efficacy by t-test,

P
<
0.05

, indicating that the effect of Du moxibustion + Western medicine treatment was better. Conclusion. The treatment of ankylosing spondylitis with kidney-yang deficiency by moxibustion + western medicine can improve the efficacy, alleviate the inflammatory response and improve the patient’s symptoms and signs, and immune indexes.
Development of Lightweight Polymer Laminates for Radiation Shielding and Electronics Applications
Authors: Vignesh S. , Winowlin Jappes J. T. , Nagaveena S. , Krishna Sharma R. , Adam Khan M. , More Chaitali V. , Rajini N. , Varol Temel
Published: October 2022

The present study portrays the development of lightweight epoxy laminates filled with boron carbide (B4C) and lead (Pb) particles through a novel layered molding and curing route. Six different laminates of single and tri-layers were prepared with varying compositions and were subjected to thermal, radiation shielding, and dielectric studies. Radiation shielding test were done using a narrow beam setup with six different sources such as Cobalt-57 (Co57-122 keV), Barium-133 (Ba133-356 keV), Sodium-22 (Na22-511 and 1275 keV), Cesium-137 (Cs137-662 keV), Manganese-54 (Mn54-840 keV), and Cobalt-60 (Co60-1170 and 1330 keV). The dielectric studies were done to understand the dielectric constant, dielectric loss factor, and AC conductivity at different temperature and frequency ranges. From the characterizations, it was found that the thermal stability of the single-layered sample increased with respect to the addition of B4C and Pb particles, which may be due to the thermally stable nature of the particles. The radiation shielding study of the samples witnessed the superior characteristics and radiation shielding ability of sample D (40% Pb) and sample E with Pb cladding at incident gamma radiation energy of 662 keV. The dielectric constant of the samples increased significantly at higher temperatures and the dielectric loss factor increased with an increase in temperature and decreased with an increase in frequency. The AC conductivity of the samples increased with respect to an increase in temperature and frequency.
Mechanical and Wear Behaviour of Nano‐Fly Ash Particle‐Reinforced Mg Metal Matrix Composites Fabricated by Stir Casting Technique
Authors: Santhosh M. S. , Natrayan L. , Kaliappan S. , Patil Pravin P. , Rao Y. Sesha , Kumar T. N. Suresh , Dhanraj Joshuva Arockia , Paramasivam Prabhu
Published: October 2022

In recent years, magnesium‐based alloys and composites have great attention in automobile, structural, and biomedical industries due to their desirable characteristics such as lower density, low elastic modulus, high specific strength, better damping properties, and excellent castability. The pure magnesium was used as a matrix material and reinforced with fly ash fillers of different compositions with a weight percentage of 2.5%, 5%, and 7.5% to compare with the pure magnesium. The three different weights (wt%) of fly ash/Mg samples were prepared using the bottom pouring stir casting method. Fabricated samples sliding wear characteristics and mechanical behaviour (ASTM standard) were studied. Wear, tensile, and hardness results portray that 7.5 wt% fly ash composites possess better elongation and hardness and good wear resistance. The tensile strength values were improved by 42% in sample 4 compared with pure Mg. Hardness values were also improved by 21% in sample 4 compared with pure Mg. The wear rate and coefficient of friction are also reduced by the increased weight percentage of fly ash reinforcement. SEM images display casted pure magnesium’s morphology and wear‐tested samples’ worn surface characteristics.
Multiobjective Approach to the Transit Network Design Problem with Variable Demand considering Transit Equity
Authors: Park Su Jin , Kang Seungmo , Byon Young-Ji , Kho Seung-Young
Published: October 2022

Existing research on the transit network design problem has tended to focus on minimizing the various costs for both transit operators and users. However, to implement an appropriate and effective transit network in urban environments, it is important not to overly simplify the intrinsically complex nature of real-life network designs. In particular, the minimization of variance in transit service levels typically employed in existing methods can be significantly improved by incorporating a transit equity component. This paper adopts a multiobjective approach that considers system efficiency, user inconvenience, and transit equity without the use of weights in order to design a more realistic and efficient transit network. In particular, the multiobjective Nondominated Sorting Genetic Algorithm-II and the neighborhood local search method are employed in a logit-based mode-choice model in order to incorporate the variable transit demand arising from the private vehicle traffic volume. A toy test network and a real-life network from the city of Goyang, Republic of Korea, are used to verify the effectiveness of the proposed model. The model finds a set of solutions that improve transit equity with minimal losses of other objectives when compared to existing approaches, which produce a significant variance in the level of service, mainly due to the spatially condensed and overlapping distribution of their transit networks. In addition, the relationship between the three objective functions and their resulting patterns in response to key influential factors are also analyzed to verify the robustness of the proposed method in response to changing future conditions.
Preparing Vocational High School Students’ 21st Century Skills Needed through Pair Work Strategy and YouTube Channel Integration
Authors: Riswanto Riswanto , Santiana Santiana , Inderawati Rita , Parmadi Bambang , Putra Pebri Prandika , Kasmaini Kasmaini , Sari Noni Purnama
Published: October 2022

There is no denying that the usage of digital media has extended throughout all parts of life as we enter the era of digital transformation. YouTube is the social media app on Android phones that people use the most, both in terms of total time and average time per user. Predicted outcomes of teaching and learning English with the use of YouTube are considered positive. This research aimed to get empirical evidence of the effect of a pair work strategy integrated with YouTube channels in increasing students’ speaking performance. This study applied a quasi-experimental design. The population of this research was the tenth-grade students at a State Vocational High School in Indonesia. There were 64 students who participated in this study. The instrument used in this research was the speaking test. A paired sample t-test was conducted to evaluate the impact of the intervention on students’ speaking performance. There was statistically significant improvement on students speaking score from Time 1 (M = 69, 41, SD = 5.988) to Time 2 (M = 86.16, SD = 4.444), t(31) = 15.516,P<0.0005. The eta squares statistic (eta squared = 0.886) indicated a large effect size. An independent sample t-test was also conducted to compare the score between experimental and control groups. The result indicated that there was significant difference in score between experimental (M = 86.16, SD = 4.444) and Control group (M = 78.50, SD = 42.65; t(62) = 7.031,p=0.001). The magnitude of the difference in the means was large (eta squared = 0.443). It indicated that 44.3% of students’ speaking score was influenced by the integration of paired work strategies and YouTube channels.
Nonenzymatic Glucose Sensor Based on Porous Co3O4 Nanoneedles
Authors: Sun Jianchun , Zhao Hongjing , Wang Zhongchang
Published: October 2022

Herein, porous Co3O4 nanoneedle arrays were synthesized on nickel (Ni) foam (Co3O4 NNs/NF) by one‐step hydrothermal method. Some electrochemical methods were used to investigate its nonenzymatic glucose sensing performance in alkaline solution. The results show that the sensitivity of Co3O4 NNs/NF electrode to glucose is 4570 μA mM-1 cm-2. The linear range is 1 μM‐0.337 mM, and the detection limit is 0.91 μM (S/N = 3). It also displays good selectivity and repeatability for glucose. The good electrochemical sensing performance of Co3O4 NNs/NF based sensor for glucose can be attributed to interconnected porous structure and large specific surface area of Co3O4.
Dynamics, Efficacies, and Adverse Effects of Maxillary Full‐Arch Intrusion Using Temporary Anchorage Devices (Miniscrews): A Finite Element Analysis
Authors: Mazhari Marzieh , Khanehmasjedi Mashallah , Mazhary Mohsen , Atashkar Nastaran , Rakhshan Vahid
Published: October 2022

Introduction. Absolute anchorages obtained from temporary anchorage devices (TADs, miniscrews) considerably facilitate dental movements and make some very difficult movements such as full‐arch intrusions possible. Despite the significance of assessing strategies to fully intrude the arch using mini‐implants, there is no study in this regard except a few case reports. Therefore, we simulated/tested 4 scenarios. Methods. Four maxilla models were created with different miniscrews/appliances: (1) two miniscrews were placed distal to laterals and one in the mid sagittal region. (2) Two mini‐implants were inserted in mesial of canines and 2 others between bilateral first and second molars, plus another TAD in the midpalatal area, plus a transpalatal arch (TPA). (3) Two mini‐implants were inserted between bilateral canines and first premolars and 2 others between bilateral first and second molars + TPA. (4) Two mini‐implants were installed between lateral‐and‐canine and 2 miniscrews between second premolars and first molars + TPA. Intrusive forces (80 g anterior, 150 g posterior) were exerted using stainless‐steel coil springs. Stresses/displacements were measured. Risk of external root resorption was evaluated. Results. The highest amounts of incisor/molar intrusion were seen in model 1. Model 2 had fewer intrusions, but its control over undesired movements was greater. Model 4 drastically reduced molar intrusion and considerably increased premolar intrusion. Overall amounts of intrusion were highest in the first 2 models, marking them as proper candidates for cases needing greater intrusion extents. Model 2 may be useful when miniscrew loosening/failure is a concern, while model 1 is recommended when fewer miniscrews are allowed. Overall, the highest and lowest root resorptions might occur in models 1 and 4, respectively. Conclusions. Each model showed certain efficacies/drawbacks and thus is recommended for a particular set of cases. Therefore, depending on the diagnosis and treatment plan, one or more of these scenarios might be desirable.
Study on Medication Rules of Traditional Chinese Medicine in Treating Constipation through Data Mining and Network Pharmacology
Authors: Xu Shu-Min , Bai Li-Peng , Lu Jin-Gen , Dong Qing-Jun , Cao Bo
Published: October 2022

Background. To explore the rules of TCM medication in the treatment of constipation in network pharmacology. Methods. Collect and screen the clinical intervention literature on TCM for constipation from China’s national knowledge infrastructure, Wanfang and VIP databases established a database of TCM for constipation, applied R software (3.3.1) to analyze the pattern of prescriptions for TCM for constipation, and summarized the core prescription. The effective active compounds and action targets in the core prescription were screened by Traditional Chinese Medicine Systems Pharmacology (TCMSP) and Traditional Chinese Medicine Integrated Databases (TCMID), constipation‐related targets were derived from the DisGeNET and GeneCards databases, Protein‐protein interaction network (PPI) was drawn by STRING database, and enrichment analysis was conducted by the Clusterprofiler package in R software (3.3.1). Finally, molecular docking was used to validate the binding ability of candidate compounds to potential targets. Results. Two hundred sixteen target prescriptions were screened through data mining, involving 226 herbs. Association rule analysis results suggested that the “Angelicae sinensis‐Radix‐dried rehmanniae‐Cistanche deserticola‐Atractylodes macrocephala‐Astragali Radix” was a strong affinity for medicine. Network pharmacology analysis of the core prescription resulted in the screening of 115 candidate compounds, such as quercetin, kaempferol, mangostin, eugenol A, and beta‐sitosterol; 131 potential targets, such as PTGS2, PTGS1, and CHRM3; and 160 signaling pathways, such as lipid and atherosclerosis, proteoglycans in cancer, hepatitis B, Kaposi’s sarcoma‐associated herpesvirus infection, and PI3K/AKT pathways. Molecular docking showed that PTGS1‐formononetin, PTGS2‐kaempferol, and CHRM3‐kaempferol were all well bound and well matched. Conclusions. This study provides a new method and ideas for clinical applications of integrated Chinese and western medicine in treating constipation.
Application Value of Management Model Based on “Zero Tolerance” Concept in Pressure Ulcer Management
Authors: Liu Yufei , Zhou Changming , Li Nan , Gong Xiaoxue
Published: October 2022

Background. Pressure injuries are the most prevalent health problem worldwide. Improving the quality of hospital pressure injury management is an important indicator to improve the quality of hospital management. Objective. To explore the application value of the management model centered on the concept of “zero tolerance” in the management of pressure ulcers (PU). Methods. The effects of conventional management mode and management mode centered on the concept of “zero tolerance” on PU patients and nursing staff were retrospectively analyzed. The patients were evaluated by the general comfort questionnaire (GCQ), Generic Quality of Life Inventory 74 (GQOL-74), and pressure ulcer healing scale (PUSH). At the same time, the satisfaction of PU patients and nursing staff with different management modes was investigated. Results. When comparing the conditions of patients under different management modes, it was found that the “zero tolerance” management mode can improve the comfort and quality of life of patients during hospitalization. Compared with the conventional management mode, the “zero tolerance” management mode can significantly improve the degree of pressure ulcer healing in patients. In addition, the “zero tolerance” management model can not only improve the satisfaction of patients with management but also improve the satisfaction of nursing staff with management. Conclusion. Standardized management of PU patients with the concept of “zero tolerance” as the core can improve the health status and quality of life of patients, promote wound healing, and improve the satisfaction of patients and nurses with the management plan.
The Cross-Postgraduate Training Mode Driven by Intelligent Signal Processing Technology: Taking the Major of Finance as an Example
Authors: Zou Jian , Zhang Yue
Published: October 2022

At present, various economic and social problems have become more complex, requiring a multidisciplinary perspective to seek solutions, and thus more complex and innovative talents are needed. Deepening the reform of postgraduate interdisciplinary education, improving the quality of postgraduate interdisciplinary education, and cultivating high-level technical talents with a multidisciplinary background, innovation ability and comprehensive quality have also become the core issues to be solved urgently in postgraduate education. This paper takes the interdisciplinary training mode of postgraduates in finance as the research object and uses interdisciplinary education theory, systems science theory, and higher education theory to explore the components and main characteristics of the postgraduate interdisciplinary training mode. On this basis, this paper investigates the current situation of interdisciplinary training of postgraduates in finance in Chinese universities and then analyzes and discusses the problems existing in the current mode of interdisciplinary cultivation of postgraduates in finance in my country. Finally, based on the above research results, relevant suggestions for improving the interdisciplinary training of postgraduates in finance in my country are put forward. The research results show that postgraduate interdisciplinary training is a new form of talent training that readjusts the source and composition of each training link after introducing the concept of interdisciplinary education. The components of the postgraduate interdisciplinary training model include interdisciplinary support elements and postgraduate training elements. The former provides interdisciplinary external support for postgraduate training, and the latter constitutes the main content of postgraduate interdisciplinary training. The research results can be used to guide the interdisciplinary educational practice of other types of postgraduates and provide certain theoretical and empirical references for cultivating more high-level compound talents urgently needed by society.
Study on the Testing Method of Relaxation Modulus under Spherical Indenter Loading
Authors: Li Xiong , Wan LunLun , Lin Fuyan , Liu Chang
Published: October 2022

Viscoelastic materials are widely used in various fields. In order to better use viscoelastic materials in various working conditions, it is necessary to master the material properties of viscoelastic materials. Relaxation modulus is a characterization method of viscoelastic material properties. In this paper, by analyzing that viscoelastic materials are time-domain related parameters, the load-time curves are obtained by using the spherical indentation instrument to carry out the ramp loading indentation test at different speeds. According to the law of ramp strain history loading, the data at different velocities are summarized and a method for judging the linear viscoelastic boundary of viscoelastic materials in spherical indentation tests is obtained. Aggregate the load-time data at different speeds to obtain a set of valid data for a longer period of time. A method of measuring the relaxation modulus using the ramp-constant strain history is proposed. Compared with the ramp loading test method, it is simple and easy to operate, and it can make up for the short time period of the measured data in the ramp loading test. The experiment verifies the feasibility of the method of ramp-constant strain history.
Development Strategy of Intelligent Digital Library without Human Service in the Era of “Internet +”
Authors: Wang Hongmei , Ding Jian
Published: October 2022

Internet technology has a great impact on the application and development of libraries. In order to provide users with more convenient and efficient services, this paper puts forward the development strategy of unmanned intelligent digital libraries in the era of “Internet +.” Design by IntelliSense module, network transmission module, data storage and analysis module, and intelligent service module of no wisdom digital library service mode, IntelliSense module using RFID technology, close range wireless communication technology, and other Internet technologies to collect the wisdom of unmanned services of all kinds of information in the digital library; use network transmission module of the wireless LAN network, Internet technology such as RFID network to transmit information collected to store in a data storage and analysis module; and at the same time using k-means clustering algorithm in data mining techniques such as analysis of collected data, based on the analysis results provide users with intelligence services such as search, wisdom is recommended. The experimental results show that the developed strategy meets the expected functional requirements, can accurately perceive the location of data, and effectively realize the intelligent service function.
An Analysis of BMP1 Associated with m6A Modification and Immune Infiltration in Pancancer
Authors: Zhou Yiyi , Xu Shuangshuang , Sun Qinying , Dong Yuchao
Published: October 2022

Background. This research explores the underlying link between diagnosis and therapy between bone morphogenetic protein 1 (BMP1) and various cancers. Methods. Three immunotherapeutic cohorts, by the composition of IMvigor210, GSE35640, and GSE78220 were obtained from previously published articles and the Gene Expression Omnibus database. The different expressions of BMP1 in various clinical parameters were conducted, and prognostic analysis was executed utilizing Cox proportional hazard regression and Gene Expression Profiling Interactive Analysis. Moreover, the correlation between BMP1 and tumor microenvironment was analyzed using ESTIMATE and CIBERSORT algorithms. Tumor mutational burden and microsatellite instability were also included. The correlation between m6A modification and the gene expression level was analyzed using Tumor IMmune Estimation Resource, the University of Alabama at Birmingham Cancer data analysis portal. Gene Set Cancer Analysis analyzed the correlation of BMP1 expression level with copy number variations and methylation. Furthermore, the correlation between BMP1 and therapeutic response after antineoplastic drug use was illustrated for further discussion. Results. BMP1 expression had significant differences in 14 cancers. It presented an intimate relationship with immune-relevant biomarkers. A variation analysis indicated that BMP1 had a significant association with immunotherapeutic response. The expression level of BMP1 was closely associated with insulin-like growth factor binding protein 3, an m6A modification relative gene. Except for a few cancer types, methylation negatively correlated with BMP1, and copy number variations positively correlated with BMP1. Notably, low BMP1 expression was connected with immunotherapeutic response in the cohorts, and its expression was related to increased sectional sensitivity of drugs. Conclusion. BMP1 may serve as a potential biomarker for prognostic prediction and immunologic infiltration in diversified cancers, providing a new thought approach for oncotherapy.
Application of BIM Technology in the Seismic Performance of “Wood Weaving” Structure of Wooden Arcade Bridges
Authors: Deng Hua
Published: October 2022

The wood arch bridge has good seismic performance, and the “wood weaving” of its arch system is closely related. Wood weaving has the isolation function similar to that of rubber bearing isolation layer under earthquake, which is the key to ensuring good isolation performance of wood arch bridges. However, it is difficult to measure the seismic performance of the “wood woven” structure of the wooden arch bridge, which leads to its limited application. In order to solve this problem, building information model (BIM) technology is introduced into this field, and the application of BIM technology in the seismic performance of “wood woven” structures of wooden arch bridges needs research. First, the design principle of “wood weaving” is described, and then the seismic principle of “wood weaving” is analyzed. Finally, from the perspective of the structural strength index, the seismic performance of the wooden arch bridge “wooden woven” structure is analyzed in depth with BIM technology in order to provide some help for understanding the seismic performance of the wooden arch bridge “wooden woven” structure and promoting the effective application of wooden arch bridge.
Analysis on the Particularity of Higher Education Subject Development under the Background of Artificial Intelligence
Authors: Wang Yancai
Published: October 2022

Subject development plays a crucial role in higher education (HE), improving student academic performance. The HE continuously requires conceptual and empirical development to deliver valuable content to the students. The subject reforms offer quality, accessibility, affordability, accountability, and equity to accomplish continual learning. The changes in higher education subjects require a continuous assessment to understand the relationship between the reform and student performance. The subject development quality is evaluated using machine learning (ML) and artificial intelligence (AI) techniques. The existing researchers use intelligent techniques to identify student academic performance. However, the exact relationship between student performance and subject changes fails to address. Therefore, higher education learning (HEL) requires improvement to manage the Higher Education Subject Development (HESD). To achieve the research goal, AdaBoost Adaptive-Bidirectional Associative Memory (AA-BAM) network is introduced in this work. The network model uses the Hebbian supervised learning (HSL) process to create the training model. The learning process has a network parameter updating procedure that reduces the total error and deviation between the academic details. In addition, the neural model uses the memory cell that stores every processing information that recalls the output patterns with maximum accuracy. The output pattern identifies the student’s academic performance, which helps to analyze the quality of the subject development in institutions. The created system ensures 98.78% accuracy, showing that subject development correlates highly with student academic performance.
Activation of PTEN/P13K/AKT Signaling Pathway by miRNA-124-3p-Loaded Nanoparticles to Regulate Oxidative Stress Attenuates Cardiomyocyte Regulation and Myocardial Injury
Authors: Cheng Yuan , He Qing , Li Na , Luo Mengdi
Published: October 2022

As a common cardiovascular disease, acute myocardial infarction seriously affects the health and life of patients. miRNAs play an important role in acute myocardial infarction. Based on miRNA obtained from the previous sequencing, this study investigated whether miRNA (miR)-124-3p-loaded nanoparticles (NPs) affect the phenotype of the acute myocardial infarction (AMI) rat. Nano-miR-124-3p decreased the myocardial infarction area, improved the myocardial tissue structure, and increased the degree of fibrosis. Nano-miR-124-3p decreased apoptosis and the expression of cleaved caspase 3, indicating its role in protecting and repairing the myocardium. To further verify the action mechanism of miRNA, a potential target gene of miR-124-3p, PTEN was identified by STARBASE and further confirmed using double luciferase assays. Following cotransfection of nano-miR-124-3p and PTEN, the areas of tissue structure damage, myocardial infarction, and fibrosis were substantially elevated. The expression of cleaved caspase 3 and the apoptosis rate in the nano-miR-124-3p and PTEN cotransfection group was also significantly increased. Bioinformatics analysis revealed that miRNA-124-3 may regulate oxidative stress injury by targeting PTEN. Taken together, miR-124-3p could protect and repair myocardial tissues through targeting PTEN.
[Retracted] Juvenile Delinquency from the Perspective of Socialization and Social Control
Authors: Zhang Tingting
Published: October 2022

In recent years, the crime rate of minors in our country has risen steadily, laying a hidden danger for the harmonious and orderly development of the country and society. The healthy growth of teenagers is not only related to the harmony of a family and the future of a nation but also to the destiny of a country. Therefore, in order to ensure the healthy growth of young people and prevent juvenile delinquency, we should start with the causes of juvenile delinquency, identifying the core issues, so as to better study juvenile delinquency. In schools and families, strengthen the education of minors and guide them to develop positively. In terms of law, strengthen the supervision of minors to prevent them from breaking the law.
Evaluation of Scientific and Technological Innovation Ability of Free Trade Zone Based on Random Forest Weighting Method
Authors: Meng Ling Yan
Published: October 2022

The scientific and technological innovation ability of the economic free trade zone is crucial to the depth and breadth of its economic development. There are too many subjective factors in the evaluation of the scientific and technological innovation ability of traditional economic free trade zones. In order to objectively evaluate the scientific and technological innovation ability of the free trade zone, this paper uses the random forest weighting method and the weighted linear combination to construct the evaluation index system, designs the evaluation model of the scientific and technological innovation ability of the free trade zone, and makes a specific analysis and evaluation based on the operation data of the economic and technological innovation ability of China’s four key free trade zones in 2020. The results show that the scientific and technological innovation ability of Guangdong economic free trade zone is the strongest, followed by Guangdong economic and trade zone, Shanghai economic and trade zone, Zhejiang economic and trade zone, and Tianjin economic and trade zone; Guangdong free trade zone has strong scientific and technological innovation ability. Compared with other free trade zones, Guangdong’s main advantages lie in the integration and aggregation ability of the industrial chain, strong policy support, and talent attraction. The scientific and technological innovation ability forms a virtuous circle. The analysis of the model example shows that the introduction of the random forest weighting method into the scientific and technological evaluation of the free trade zone can more objectively compare and analyze the scientific and technological innovation ability of the free trade zone, which is of great significance to help the free trade zone find out the problems and shortcomings in the scientific and technological innovation ability and improve the level of scientific and technological innovation.
[Retracted] Analysis of the Relationship between National Image Building and International Communication Ability from the Perspective of Ecology under the Media Environment
Authors: Zhu Ziyuan , Zhang Chao
Published: October 2022

With the gradual expansion of China’s political, economic, and military strength, the rapid rise of China has become a globally recognized fact. At present, although China’s international image as the world’s second largest economy, military power, and political power has been increasingly accepted by the global community, China’s image construction, as an important part of national soft power, is still facing many problems. This chapter focuses on defining the basic concepts of international publicity, China’s soft power, and China’s image construction in the context of new media integration, analyzes the international development trend of international publicity and the important functions and limitations of foreign publicity in establishing China’s image construction, and analyzes the ecological environment of media integration development. Considering that there are great unfairness in the environment and the conflict of communication values is not conducive to the establishment of China’s urban image, the article focuses on how to use global publicity values to establish China’s national image and puts forward corresponding countermeasures.
Optimization Model of Employment and Entrepreneurship Guidance for University Graduates Using Credible Neural Network and Spark Big Data Technology
Authors: Su Kaimin
Published: October 2022

China’s economy has grown significantly since the turn of the century, and its domestic situation has become more stable. The employment and employment issues that college graduates encounter across the nation, however, demonstrate the opposite tendency. The general public’s attention has turned to “difficulty in getting employment,” which has emerged as a crucial component of the overall social employment problem. Additionally, it examines the environment and elements that influence college students’ employment, such as the social, economic, and policy elements as well as the university, employer, and individual elements. This study examines the development of college students’ entrepreneurial service system by using colleges and universities as the research object and integrating theoretical analysis with empirical research. The M Apriori technique is then parallelized using a Spark and Credible neural network-based approach. This solution makes full use of Spark’s benefits based on in-memory processing and data item RDD storage by adopting data parallelism and a local rather than global strategy. The M Apriori algorithm is parallelized and ported to the Spark platform for parallelization, enhancing Spark MLlib. The simulation test and analysis are completed in the end. The study’s findings demonstrate the algorithm’s excellent accuracy, which is 8.65% greater than that of the Apriori method. Finally, the experimental findings demonstrate the effectiveness of the method used in this paper.
Vibration Isolation and Noise Reduction Method Based on Phononic Crystal
Authors: Li Haiqing , Sun Ping
Published: October 2022

Phononic crystal is a new kind of sound insulation material, which has an elastic wave gap. When the elastic wave falls within the band gap, it will attenuate strongly in phononic crystal, and its attenuation degree is far greater than the predicted value of the mass density theorem. In this paper, the practical application of phononic crystals in low frequency sound insulation is taken as the breakthrough point. Firstly, the theory of phononic crystal band gap generation is calculated and analyzed, and the band structure of one-dimensional two-component Bragg scattering phononic crystals is calculated. Hypermesh is used to build the model, and the sound insulation performance of phononic crystals is simulated and analyzed through Nastran. A sound isolation test platform was built for the local resonant phononic crystal samples to verify its sound isolation ability.
A Case Report of Adrenal Teratoma: Huge but Easy to Misdiagnose
Authors: Zhou Feng , Sun Junjie , Chen Xiaoyi , Sun Guoliang , Jin Baiye
Published: October 2022

Primary adrenal teratoma is a rare lesion with a high misdiagnosis rate. In view of the fact that adrenal teratoma and adrenal gland are often inseparable, the removal of the affected adrenal gland seems inevitable. Thus, it is necessary for clinicians to differentiate adrenal teratoma from common adrenal lipoma diseases, such as adrenal angiomyolipoma, adrenal myelolipoma, lipoma, gangliocytoma, and so on. In this study, we reported the clinical and pathologic features of 7 patients surgically treated for adrenal mature teratomas from 2007 to 2020 in our hospital. We compared the clinical characteristics and surgical management in literature review cases with our cases. All patients were females and underwent open adrenalectomy or laparoscopic adrenalectomy, respectively. In our cases, there was no recurrence during the longest follow-up of 13 years. Adrenal teratoma is rare and easy to ignore. And once misdiagnosed, the surgeon may need to adjust the operation temporarily, extend the operation time and finally increase the operative risks. Our aim is mainly to help clinicians to raise awareness of adrenal teratomas, improve the diagnosis rates and optimize the treatment decision-making of this disease.
Recent Advances in Castleman Disease
Authors: Hoffmann Christian , Hentrich Marcus , Tiemann Markus , Rosenwald Andreas , Weber Florian , Willenbacher Wolfgang , Hübel Kai
Published: October 2022

Background: Castleman disease (CD) encompasses a spectrum of rare disorders with characteristic histopathological features. Unicentric CD (UCD) is a benign, local hyperplasia of lymphoid tissue that is usually curable. Multicentric CD (MCD) manifests as a potentially life-threatening systemic disease with complex symptomatology which is mostly due to an overproduction of interleukin-6 (IL-6) or dysregulation of IL-6-related signaling pathways. From a therapeutic perspective, it is important to distinguish idiopathic MCD (iMCD) from those cases that are associated with the human herpesvirus-8 (HHV-8 + MCD). Summary: During recent years, it has become increasingly clear that even HHV-8-negative MCD is not a homogeneous entity and that there are clinically distinct variants. International consensus guidelines for diagnosis and treatment have been developed for iMCD and UCD. Key Messages: We herein summarize recent advances in diagnosis, treatment, and novel insights into the pathogenesis of this disease.
Pacientes jóvenes con CPCNP: Ofrecer siempre un diagnóstico histológico y molecular si se sospecha una neoplasia
Authors: Sánchez-Ríos Carla Paola
Published: October 2022

Background: We investigated the correlation between genetic mutations and clinical-pathological features in young patients with NSCLC. Methods: Clinicopathologic information of 102 young NSCLC patients was collected. Direct ctDNA sequencing of a portion of these patients was performed. The correlation between EGFR mutation and ALK fusions with clinicopathologic parameters was analyzed. Results: In young NSCLC patients, adenocarcinoma is the major histology (86.9%), and the misdiagnosis rate was as high as 45.7%. EGFR gene mutation was found in 13 patients (31.7%) and common mutations were with EGFR19del mutation (7 cases, 17.1%) and EGFR21L858R mutation (4 patients, 9.7%). EGFR mutation was constantly found in adenocarcinoma and male gender, and ever smokers (100%, P < 0.05). Furthermore, ALK fusions were found in 7 patients (31.8%), which include EML-4-ALK fusions; there was a trend that ALK fusions were associated with adenocarcinoma and female gender. However, there was no significant difference in overall survival between patients with or without gene mutations. Conclusions: EGFR mutation and ALK fusions are related to histology, gender, and smoke exposure in young NSCLC patients, and may be effective predictive factors.
(Re)Formação docente em Contabilidade: uma reflexão sobre os programas de doutorado no Brasil
Authors: Nganga Camilla Soueneta Nascimento , Casa Nova Silvia Pereira de Castro , Lima João Paulo Resende de
Published: October 2022

No presente trabalho problematizamos a formação docente em Contabilidade no Brasil, por meio da análise dos componentes curriculares voltados para o ensino e pesquisa dos cursos de doutorado da área de Ciências Contábeis. A coleta de dados foi realizada na plataforma Sucupira, considerando as seguintes informações da coleta CAPES de 2019 dos 15 cursos de doutorado existentes no país: objetivos do doutorado; linhas de pesquisa; projetos de pesquisa; disciplinas (formação para o ensino); disciplinas (formação para a pesquisa); e estágio docência. No tocante à formação voltada para o ensino, o cenário atual é preocupante, pois apresenta poucas mudanças em relação aos estudos anteriores, demonstrando poucas iniciativas para a formação pedagógica inicial, fazendo com que os docentes se autorresponsabilizem por seu desenvolvimento didático-pedagógico. Acerca da formação para a pesquisa, os resultados indicam uma formação pautada por disciplinas de caráter metodológico e métodos quantitativos, demonstrando uma formação voltada para o mainstream. A partir desses resultados, esperamos contribuir para a reflexão sobre a (re)formação docente nos programas de doutorado em Contabilidade no Brasil, em um momento de expansão e consolidação da área.