bluuebunny/crossref_metadata_2025 huggingface dataset:
Antifungal Potential of Synthetic Peptides against Cryptococcus neoformans: Mechanism of Action Studies Reveal Synthetic Peptides Induce Membrane–Pore Formation, DNA Degradation, and Apoptosis
Authors: Aguiar Tawanny K. B. , Neto Nilton A. S. , Freitas Cleverson D. T. , Silva Ayrles F. B. , Bezerra Leandro P. , Malveira Ellen A. , Branco Levi A. C. , Mesquita Felipe P. , Goldman Gustavo H. , Alencar Luciana M. R. , Oliveira Jose T. A. , Santos-Oliveira Ralph , Souza Pedro F. N.
Published: August 2022

Cryptococcus neoformans is a human-pathogenic yeast responsible for pneumonia and meningitis, mainly in patients immunocompromised. Infections caused by C. neoformans are a global health concern. Synthetic antimicrobial peptides (SAMPs) have emerged as alternative molecules to cope with fungal infections, including C. neoformans. Here, eight SAMPs were tested regarding their antifungal potential against C. neoformans and had their mechanisms of action elucidated by fluorescence and scanning electron microscopies. Five SAMPs showed an inhibitory effect (MIC50) on C. neoformans growth at low concentrations. Fluorescence microscope (FM) revealed that SAMPs induced 6-kDa pores in the C. neoformans membrane. Inhibitory assays in the presence of ergosterol revealed that some peptides lost their activity, suggesting interaction with it. Furthermore, FM analysis revealed that SAMPs induced caspase 3/7-mediated apoptosis and DNA degradation in C. neoformans cells. Scanning Electron Microscopy (SEM) analysis revealed that peptides induced many morphological alterations such as cell membrane, wall damage, and loss of internal content on C. neoformans cells. Our results strongly suggest synthetic peptides are potential alternative molecules to control C. neoformans growth and treat the cryptococcal infection.
Bone-Targeted Delivery of Novokinin as an Alternative Treatment Option for Rheumatoid Arthritis
Authors: Ranjit Arina , Khajeh pour Sana , Aghazadeh-Habashi Ali
Published: August 2022

Rheumatoid arthritis (RA) is an autoimmune inflammatory bone destructive disorder that is orchestrated by multiple systems in the body, including Renin-Angiotensin System (RAS) and arachidonic acid (ArA) pathway. Current therapeutic options are not highly effective and are associated with severe side effects, including cardiovascular complications. Therefore, new safe and effective disease modulators are seriously needed. In this study, we investigate the anti-inflammatory effects of a synthetic peptide, novokinin, through Angiotensin Type (II) receptor (AT2R). Peptide drugs like novokinin suffer from plasma instability and short half-life. Thus, we developed a novel bone targeting novokinin conjugate (Novo Conj). It uses the bone as a reservoir for sustained release and protection from systemic degradation, improving stability and enhancing pharmacological efficacy. We tested Novo Conj’s anti-inflammatory effects in adjuvant-induced arthritis (AIA) rat model to prove our hypothesis by measuring various RAS and ArA pathway components. We observed that inflammation causes a significant imbalance in cardioprotective RAS components like ACE2, AT2R, and Ang 1-7 and increases the ArA inflammatory metabolites like hydroxyeicosatetraenoic acids (HETEs). Treatment with novokinin or Novo Conj restores balance in the RAS and favors the production of different epoxyeicosatrienoic acids (EETs), which are anti-inflammatory mediators. This study demonstrated that the bone-targeted delivery improved the stability and enhanced the anti-inflammatory effects of the parent peptide novokinin in AIA. These observations offer an efficacious alternative therapy for managing RA.
Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood–Brain Barrier
Authors: Kurosawa Toshiki , Tega Yuma , Uchida Yasuo , Higuchi Kei , Tabata Hidetsugu , Sumiyoshi Takaaki , Kubo Yoshiyuki , Terasaki Tetsuya , Deguchi Yoshiharu
Published: August 2022

A proton-coupled organic cation (H+/OC) antiporter working at the blood–brain barrier (BBB) in humans and rodents is thought to be a promising candidate for the efficient delivery of cationic drugs to the brain. Therefore, it is important to identify the molecular entity that exhibits this activity. Here, for this purpose, we established the Proteomics-based Identification of transporter by Crosslinking substrate in Keyhole (PICK) method, which combines photo-affinity labeling with comprehensive proteomics analysis using SWATH-MS. Using preselected criteria, the PICK method generated sixteen candidate proteins. From these, knockdown screening in hCMEC/D3 cells, an in vitro BBB model, identified two proteins, TM7SF3 and LHFPL6, as candidates for the H+/OC antiporter. We synthesized a novel H+/OC antiporter substrate for functional analysis of TM7SF3 and LHFPL6 in hCMEC/D3 cells and HEK293 cells. The results suggested that both TM7SF3 and LHFPL6 are components of the H+/OC antiporter.
Mucosal Delivery of Cannabidiol: Influence of Vehicles and Enhancers
Authors: Tabboon Peera , Pongjanyakul Thaned , Limpongsa Ekapol , Jaipakdee Napaphak
Published: August 2022

In this study, the mucosal permeation and deposition of cannabidiol (CBD) with neat and binary vehicles were investigated. Permeation experiments were performed using static diffusion cells coupled with fresh porcine esophageal mucosa. The CBD–vehicle solutions were applied at a fixed dose (~5 mg/cm2), and the corresponding permeation parameters were calculated. In neat vehicles, the permeation flux (Jss) ranged from 0.89 ± 0.15 to 179.81 ± 23.46 µg·cm−2·h−1, while the CBD deposition ranged from 11.5 ± 1.8 to 538.3 ± 105.3 μg·cm−2. Propylene glycol (PG) and diethylene glycol monoethyl ether (DEGEE) yielded the highest permeability (Ps) and CBD deposition, while medium-chain triglycerides (MCT) yielded the lowest Ps and deposition. This was due to the difference in apparent partition coefficient (K), which is related to the solubility of CBD in the vehicle. The PG:DEGEE binary vehicle boosted Jss (1.5–1.6 fold) and deposition (2.0–2.7 folds) significantly, compared to neat DEGEE. The combination of DEGEE with MCT dramatically enhanced Jss (11–44 fold) and deposition (1.6–4.7 fold). The addition of lipophilic enhancers, laurocapram, and oleic acid, to PG:DEGEE and DEGEE:MCT vehicles significantly reduced Jss (0.3–0.7 fold) and deposition (0.4–0.8 fold) while nerolidol had no effect. These permeation reductions were found to be related to modification of the K and/or diffusivity values. This study provides useful basic information for the development of CBD formulations intended for transmucosal delivery.
Development of Alectinib-Suspended SNEDDS for Enhanced Solubility and Dissolution
Authors: Park Eun Ji , Choi Seung Ah , Min Kyoung Ah , Jee Jun-Pil , Jin Sung Giu , Cho Kwan Hyung
Published: August 2022

Alectinib hydrochloride (ALH), a tyrosine kinase inhibitor, is a practically water-insoluble drug classified as BCS class IV. The present study aimed to develop novel suspended self-nanoemulsifying drug delivery system (Su-SNEDDS) to enhance the solubility and dissolution rate. The Su-SNEDDS was prepared by saturation and suspension of ALH in SNEDDS with ultrasonication energy. According to evaluation by the dispersion test and the results of particle size analysis, the selected SNEDDS composed of Kolliphor HS 15 and Capmul MCM C8 as surfactant and oil, respectively, showed a complete dissolution within 30 min. However, the SNEDDS loaded and solubilized only small amount of ALH (<0.6%, w/w). On the other hand, 10% ALH-loaded Su-SNEDDS containing small and micronized ALH particles of <5 μm had about 20-fold higher ALH-loading% than the SNEDDS and reached a 100% dissolution rate within 30 min in 1% sodium lauryl sulfate (SLS) pH 1.2 buffer. In the dispersion test and microscopic observation, micronized ALH particles in the Su-SNEDDS were readily dispersed in the dissolution medium with spontaneous nanoemulsion formation and instantly solubilized with the aid of SLS. Taken together, our results suggest that the Su-SNEDDS would be a potent oral dosage form to enhance the solubilization and dissolution rate of ALH in a new technological way.
Correction: Villalobos-González et al. Photoprotection Is Achieved by Photorespiration and Modification of the Leaf Incident Light, and Their Extent Is Modulated by the Stomatal Sensitivity to Water Deficit in Grapevines. Plants 2022, 11, 1050
Authors: Villalobos-González Luis , Alarcón Nicolás , Bastías Roberto , Pérez Cristobal , Sanz René , Peña-Neira Álvaro , Pastenes Claudio
Published: August 2022

In the original publication [...]
A Pipeline NanoTRF as a New Tool for De Novo Satellite DNA Identification in the Raw Nanopore Sequencing Reads of Plant Genomes
Authors: Kirov Ilya , Kolganova Elizaveta , Dudnikov Maxim , Yurkevich Olga Yu. , Amosova Alexandra V. , Muravenko Olga V.
Published: August 2022

High-copy tandemly organized repeats (TRs), or satellite DNA, is an important but still enigmatic component of eukaryotic genomes. TRs comprise arrays of multi-copy and highly similar tandem repeats, which makes the elucidation of TRs a very challenging task. Oxford Nanopore sequencing data provide a valuable source of information on TR organization at the single molecule level. However, bioinformatics tools for de novo identification of TRs in raw Nanopore data have not been reported so far. We developed NanoTRF, a new python pipeline for TR repeat identification, characterization and consensus monomer sequence assembly. This new pipeline requires only a raw Nanopore read file from low-depth (<1×) genome sequencing. The program generates an informative html report and figures on TR genome abundance, monomer sequence and monomer length. In addition, NanoTRF performs annotation of transposable elements (TEs) sequences within or near satDNA arrays, and the information can be used to elucidate how TR–TE co-evolve in the genome. Moreover, we validated by FISH that the NanoTRF report is useful for the evaluation of TR chromosome organization—clustered or dispersed. Our findings showed that NanoTRF is a robust method for the de novo identification of satellite repeats in raw Nanopore data without prior read assembly. The obtained sequences can be used in many downstream analyses including genome assembly assistance and gap estimation, chromosome mapping and cytogenetic marker development.
Synthesis of Carbosilane and Carbosilane-Siloxane Dendrons Based on Limonene
Authors: Ryzhkov Aleksei , Drozdov Fedor , Cherkaev Georgij , Muzafarov Aziz
Published: August 2022

In this work, carbosilane dendrons of the first, second, and third generations were obtained on the basis of a natural terpenoid, limonene. Previously, we have shown the possibility of selective hydrosilylation and hydrothiolation of limonene. It is proved that during hydrosilylation, only the isoprenyl double bond reacts, while the cyclohexene double bond does not undergo into the hydrosilylation reaction. However, the cyclohexene double bond reacts by hydrothiolation. This selectivity makes it possible to use limonene as a dendron growth center, while maintaining a useful function—a double bond at the focal point. Thus, the sequence of hydrosilylation and Grignard reactions based on limonene formed carbosilane dendrons. After that, the end groups were blocked by heptamethyltrisiloxane or butyllithium. The obtained substances were characterized using NMR spectroscopy, elemental analysis and GPC. Thus, the proposed methodology for the synthesis of carbosilane dendrons based on the natural terpenoid limonene opens up wide possibilities for obtaining various macromolecules: dendrimers, Janus dendrimers, dendronized polymers, and macroinitiators.
Numerical Computation of Anisotropic Thermal Conductivity in Injection Molded Polymer Heat Sink Filled with Graphite Flakes
Authors: Brachna Robert , Kominek Jan , Guzej Michal , Kotrbacek Petr , Zachar Martin
Published: August 2022

The use of polymer composites as a replacement for commonly applied materials in industry has been on the rise in recent decades. Along with the development of computer software, the desire to predict the behavior of new products is thus increasing. Traditional additives in the form of fibers cause anisotropic properties of the whole product. The subject of the presented study is a polymer heat sink prototype with a thermally conductive filler in the form of graphite flakes, which differs from the commonly used fibers. Three simplified approaches are introduced to model the thermal conductivity anisotropy of an entire heat sink. Each model is subjected to an inverse heat conduction problem, the output of which are thermal conductivity values. These are optimized to minimize the difference between simulated and experimental temperatures at selected locations in the model. The approaches are compared with each other with respect to their error against the experimentally obtained results. The goal is to find a sufficiently simplified approach that can be applied to products of various geometries. This would remove the costly and time-consuming need for mold production and experimental testing.
Conducting Composite Material Based on Chitosan and Single-Wall Carbon Nanotubes for Cellular Technologies
Authors: Kodolova-Chukhontseva Vera Vladimirovna , Shishov Mikhail Alexandrovich , Kolbe Konstantin Andreevich , Smirnova Natalia Vladimirovna , Dobrovol’skaya Irina Petrovna , Dresvyanina Elena Nikolaevna , Bystrov Sergei Gennadievich , Terebova Nadezda Semenovna , Kamalov Almaz Maratovich , Bursian Anna Ericovna , Ivan’kova Elena Mikhailovna , Yudin Vladimir Evgenievich
Published: August 2022

Biocompatible electrically conducting chitosan-based films filled with single-wall carbon nanotubes were obtained. Atomic force microscopic studies of the free surface topography revealed a change in the morphology of chitosan films filled with single-wall carbon nanotubes. Introducing 0.5 wt.% of single-wall carbon nanotubes into chitosan results in an increase in tensile strength of the films (up to ~180 MPa); the tensile strain values also rise up to ~60%. It was demonstrated that chitosan films containing 0.1–3.0 wt.% of single-wall carbon nanotubes have higher conductivity (10 S/m) than pure chitosan films (10−11 S/m). The investigation of electrical stimulation of human dermal fibroblasts on chitosan/single-wall carbon nanotubes film scaffolds showed that the biological effect of cell electrical stimulation depends on the content of single-walled carbon nanotubes in the chitosan matrix.
Computational Modeling of Polymer Matrix Based Textile Composites
Authors: Šejnoha Michal , Vorel Jan , Valentová Soňa , Tomková Blanka , Novotná Jana , Marseglia Guido
Published: August 2022

A simple approach to the multiscale analysis of a plain weave reinforced composite made of basalt fabrics bonded to a high performance epoxy resin L285 Havel is presented. This requires a thorough experimental program to be performed at the level of individual constituents as well as formulation of an efficient and reliable computational scheme. The rate-dependent behavior of the polymer matrix is examined first providing sufficient data needed in the calibration step of the generalized Leonov model, which in turn is adopted in numerical simulations. Missing elastic properties of basalt fibers are derived next using nanoindentation. A series of numerical tests is carried out at the level of yarns to promote the ability of a suitably modified Mori–Tanaka micromechanical model to accurately describe the nonlinear viscoelastic response of unidirectional fibrous composites. The efficiency of the Mori–Tanaka method is then exploited in the formulation of a coupled two scale computational scheme, while at the level of textile ply the finite element computational homogenization is assumed, the two-point averaging format of the Mori–Tanaka method is applied at the level of yarn to serve as a stress updater in place of another finite element model representing the yarn microstructure as typical of FE2 based multiscale approach. Several numerical simulations are presented to support the proposed modeling methodology.
Antibacterial Films Made of Bacterial Cellulose
Authors: Sun Zhenbing , Li Xiaoping , Tang Zhengjie , Li Xiaobao , Morrell Jeffrey J. , Beaugrand Johnny , Yao Yao , Zheng Qingzhuang
Published: August 2022

Bacterial cellulose (BC) is naturally degradable, highly biocompatible, hydrophilic, and essentially non-toxic, making it potentially useful as a base for creating more sophisticated bio-based materials. BC is similar to plant-derived cellulose in terms of chemical composition and structure but has a number of important differences in microstructure that could provide some unique opportunities for use as a scaffold for other functions. In this study, bacterial cellulose was alkylated and then esterified to produce a carboxymethyl bacterial cellulose (CMBC) that was then used to produce six different composite films with potential antibacterial properties. The films were assessed for antibacterial activity against Staphylococcus aureus and Escherichia coli, pyrolysis characteristics using thermogravimetric analysis (TGA), microstructure using scanning electron microscopy (SEM), and mechanical properties. The addition of nano-silver (nano-Ag) markedly improved the antimicrobial activity of the films while also enhancing the physical and mechanical properties. The results indicate that the three-dimensional reticulated structure of the bacterial cellulose provides an excellent substrate for scaffolding other bioactive materials. Thus, the nano-BC was added into the CMBC/nano-Ag composites furthermore, and then the antibacterial and mechanical properties were improved 44% for E. coli, 59% for S. aureus, and 20% for tensile strength, respectively.
The Potential of Pharmaceutical Hydrogels in the Formulation of Topical Administration Hormone Drugs
Authors: Ostróżka-Cieślik Aneta
Published: August 2022

Hormones have attracted considerable interest in recent years due to their potential use in treatment of many diseases. Their ability to have a multidirectional effect leads to searching for new and increasingly effective drugs and therapies. Limitations in formulating drug forms containing hormones are mainly due to their low enzymatic stability, short half-life and limited bioavailability. One of the solutions may be to develop a hydrogel as a potential hormone carrier, for epidermal and transdermal application. This review discusses the main research directions in developing this drug formulation. The factors determining the action of hormones as drugs are presented. An analysis of hydrogel substrates and permeation enhancers that have the potential to enhance the efficacy of hormones applied to the skin is reviewed.
THE CONSTRUCTION OF SOCIALISM IN A SINGLE COUNTRY AND THE CRITICAL EVOLUTION OF THE SOCIALIST IDEAL
Authors: Lyubinin Aleksandr B.
Published: August 2022

The final article in the series of materials published by the author in the “Russian Economic Journal” in the period 1917–1921 on the history, methodology and theory of Soviet socialism. It shows the objective influence of the Bolsheviks’ transition to the concept of building socialism in a single, poorly industrialized country on the socio-economic, political and spiritual appearance of Soviet society, the theoretical ideas about socialism that have arisen. The causes, role and future consequences of the current mobilization pattern focused on the survival of the USSR in an unfriendly environment are investigated; the significance of the combination of ideological and national tasks. The article analyzes the history of the formation of the imperfection of the socialist ideal, which was gradually formed as a high and inevitable payment for the positive result achieved in the formation of socialism and the dissemination of its ideas. It is emphasized that it was this circumstance, existential in its significance for the fate of socialism, that set an ambiguous socio-political situation in the life of a Soviet person, on the one hand, who was really able to think about the motherland before, and only then about himself, and on the other, who did not come to the war for this very homeland, having lost during the years of hard work the struggle and the difficult life of faith in the ideological and moral ideals and advantages of socialism.
A future educational role for the family to deal with the phenomenon of divorce in Jordan
Authors: Al Momani Amal
Published: August 2022

The study aims to build a future educational role for the family to deal with the phenomenon of divorce that is by identifying the reasons leading to divorce from the point of view of divorced wives and husbands, the implications of divorce on both the wife and children, and the degree of difference in the reasons leading to divorce, according to gender, age, level of education and income for wives and divorced husbands in Jordan. The study population consisted of all divorce cases in the Kingdom in  the last five years from 2012 to 2016, which number (24898) divorces. Based on this, the study recommends spreading awareness about the dangers of domestic violence and its repercussions leading to divorce, holding seminars on family issues and the rights of both husband and wife, and making them aware of the problems that both spouses may encounter.
The Degree of Democratic Relationship between University Teacher and Student in the Internet Age from Student's Point of View
Authors: Nathir Darwazeh Afnan
Published: August 2022

A random sample of (632) male and female undergraduate students was taken from northern Palestinian Universities: (239) from An-Najah (NU), (200) from Arab-American (AAU), and (109) from Palestine-Technical University/Khaduri (PT/KU). A questionnaire of (37) items measuring the teacher-student democratic relationship in two domains: academic and social domains were administered on the sample.  The data was manipulated by using the descriptive statistics on one hand, and the analytic statistics using "t-test" and "f-test" at (p<.05) level of significant on the other.  Accordingly, the study founded that the general mean of democratic relationship between the teacher and student in three universities was (3.46) pints out of five.  F-test revealed that the mean of (PTUK) was higher significantly than (AAU) and (NU).  The results also revealed that the mean of democratic relationship in the academic domain was higher significantly than that in the social domain. With respect to the other related independent variables, the study revealed that the means of democratic relationship of freshmen and sophomore were higher than that of junior and senior; that of students whose age between 18-20 was higher than that of older ones who aged between 21-23, 24-26, or 27 and more; that of students who had a scientific background in General High School Exam was higher than that of students who had a literature or commercial back ground; and that of students who see themselves as cultured was higher than that of those who see their culture medium or weak.

These results came along with discussions, recommendations for further future studies.
History of Democratization in Contemporary Spain Since (1936-1978)
Authors: Al-Shunnaq Abdulmajeed , Hussain Shawkat
Published: August 2022

This study addresses the issue of the history of democratic transformation from the general dictatorial regime of General Francois to his death, which opened the door for transformation through gradual political reform, especially after the return of the monarchy led by Juan Carlos. The democratic forces succeeded in light of an open policy that believes in pluralism, and the freedom of Parties and unions, and the freedom of the media which guaranteed by the Constitution issued in 1978.  In addition to these factors, European countries and the United States of America have played a supporting moral, cultural and economic role in the process of democratization in Spain in the contemporary history.
The Effect of Self-Sufficiency in Interior Design and Its Reflection on User’s Behavior within Built Environments
Authors: Obeidat Islam
Published: August 2022

This research studies the importance of self-sufficiency and its relationship to interior design and its effect on user behavior within built environments. Interior designers must take into account design elements that achieve self-sufficiency in the built environments, such as: energy, ventilation, lighting, water treatment and self-maintenance. The research problem lies in the lack of a clear vision and basis on which to draw upon to know the impact of self-sufficiency in interior design and the dangerous effects it has on the built environment and on the behavior of users and the effective impact of these elements, directly or indirectly, which in turn affect comfort, well-being, health and safety, and the privacy of individuals within their environments. The main question comes to know what the importance of achieving self-sufficiency in interior design is and how it might affect the behavior of users within the built environments. The methodology used in this research is descriptive and analytical, whereby questionnaires and personal interviews were made with a group of users within their built environments, the results were analyzed and the necessary recommendations were made in this research. The results of the research revealed that self-sufficiency affects the behavior of users positively and is reflected in their daily activities within the built environments, self-sufficiency in interior design plays a clear role in influencing the comfort, well-being, health, safety and privacy of users, and finally, this effect is tangibly reflected on their performance, productivity and loyalty to their environments.
The Relationship between Interior Design and Historical Society (An Analytical Study)
Authors: Thabit Al-Baldawi Mohammed
Published: August 2022

The interior design is a living and honest expression of the culture of people, it shows  the strong and clear relationship of the community in architecture and inte

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* Digital Arts & Design , Khwarizmi University Technical College.

Received on 23/1/2020 and Accepted for Publication on 8/2/2021.

rior design throughout history since the beginning of creation. This study aims to shed light on the following lines: The relationship of interior design to society, the study of internal design and its historical development, and analysis by using the analytical descriptive approach to residential houses in Amman. The study concluded with a set of recommendations: Highlight developments that accompanied architecture, Dealing with the latest developments of technology in terms of subjecting the thought of the designer and the philosophy of his community by adapting them to this thought, and Dealing with the environment in an overall concept to achieve the concept of sustainability in design and in order to reach the highest quality.
The Spatial Displacement in the Drawings of Hashim Hanoun
Authors: Obaid Nasser Mohammed , Aziz Nasser Ali
Published: August 2022

The research consists of four chapters, the first of which included the problem of research, its importance, its purpose and its limits. The second chapter contains three topics ; the first of which is entitled displacement - the term and the concept, while the second title relation displacement in place, the third focused on the intellectual references to the artist (Hashim Hanoun) Chapter  three (Research Procedures) is limited in terms of the limitation of the research community and its design and guidance, while Chapter four the results of the research and its conclusions, and from the results, displacement is a functional component of the art that awakens the language of art of semantic semantic lexicon iconic, to perform a function of inspiration, because it gives it pluralism of meaning
Childhood Abuse as Experienced by Early Childhood Education Students
Authors: Ahmad Jamal
Published: August 2022

The study aims to survey childhood abuse (CA) experiences among early childhood education students in Jordan. An open-ended survey question was used to collect data from 311 students. Data were analyzed using thematic analysis. Results revealed that all participants reported exposure to abuse during childhood, but differed in the types of abuse experienced. Participants reported verbal abuse most frequently and sexual abuse least frequently. Results also revealed that the most frequent abuser reported was the child’s teacher and the least frequent was the child’s friend. The effects of the abuse on the victims are presented
The importance of modern digital technologies in the Jordanian film industry The movie "Captain Abu Raed" as a model
Authors: Alfaleh Ahmad , Fayad Ali
Published: August 2022

Modern digital technologies in cinema have added a great development in many fields; the most important of which is the field of cinematography, lighting, and the field of film editing. This research highlights the important role of these technologies in the development of the Jordanian digital cinematic film industry by analyzing one film as a sample, the Jordanian digital film "Captain Abu Raed", which used modern digital technologies in its production in cinema in 2008. The film is analyzed qualitatively and the role of modern digital technologies in making is examined. The research consists of four sections, where the first section includes the definition of the research problem, objectives, significane, the procedural definitions, and the research sample. The second section includes the theoretical framework for the research, where the research discusses the importance of modern digital technologies in Jordanian cinema and their development, and presents a theoretical framework regarding the basic elements in digital cinematography as follows: cinematography, lighting, and film editing. The third section also analyzes the research sample, which is a Jordanian digital cinematic film "Captain Abu Raed", and it highlights the digital technical aspects in its production. The fourth section includes the research results related to the research.
The association of home quarantine during the Covide-19 pandemic on the lifestyle and mental wellbeing of citizens in Jordan
Authors: M. Al-Nawaiseh Ali , Kilani Hashem , F. Bataineh Mo’ath , Atiyat Khaled , Al-Kilani Maher , Mansi Tayseer , Jaber Ruba , Swidan Ahmad
Published: August 2022

During the COVID-19 pandemic a home confinement was enforced in Jordan, We investigated the physical activity, dietary status and sleep quality and mental wellbeing during the lockdown, A sample of Jordanian adults (N =1088, 18-65 Years Old) answered the survey which employed the use of the following tools to conduct information:1- Food Frequency Questionnaire (FFQ), 2- International Physical Activity Questionnaire (IPAQ), 3- WHO-5 Mental wellbeing score, and 4- Pittsburgh Sleep Quality Index (PSQI). Participants of the study (565 females and 523 males) who completed the online survey consented to answer the survey questions after being assured that all their responses will be kept unanimous and no questions will reveal their identity. Statistical analysis (ANOVA) showed differences in the mental wellbeing index according to the physical activity level (F (2, 1087) = 49.181; P <0.0001). T-test also showed that there was a significant difference in the mental wellbeing index according to sleep quality (t = (1086) = -13.476; P <0.0001), and participants’ nutritional status (t = (1086) = -6.078; P <0.0001). Pearson correlation coefficient analysis indicated significant positive relationship between mental wellbeing and daily physical activity level (r = 0.324; P) <0.0001). Furthermore, results revealed that mental wellbeing was negatively correlated with sleep quality (r = -0.419; P <0.0001) and noticed to be higher among participants with better dietary status (r = 0.255; P <0.0001). It is concluded that enhancing nutritional status and increasing physical activity are keys to maintain mental wellbeing during home confinement associated with the Corona pandemic
Réseau sociaux et expression identitaire féminine: quelle présentation de soi?
Authors: Jaradat Riham
Published: August 2022

Basée sur un corpus recueilli de posts publiés sur Facebook par une population de jeunes femmes jordaniennes (18-22 ans), cette étude se veut une réflexion pragmatico-énonciative qui tend d’identifier et d’analyser les procédés discursifs propres aux affirmations identitaires dans leurs différentes configurations linguistiques de subjectivité. Il s’agit également de découvrir le rôle que joue le rapport à l’altérité dans la construction de toute représentation identitaire. L’étude démontre que l’extériorisation d’un soi positif, prestigieux et optimiste se trouve plus accentué sur Facebook que dans les interactions de face-à-face, et que les posts sont publiés pour être appropriés par le public de lecteurs.
Youth Awareness Level of the Indicators of Achieving Gender Equality as One of Sustainable Development Goals
Authors: Alarab Asmas , Alrawashdeh Alaa , Siraj Eldeen F. Ahmed Osman
Published: August 2022

The study aims at identifying the Youth Awareness level of the indicators of achieving Gender equality as one of sustainable development goals.A descriptive and historical approach has been used to achieve the goals of the study.A questionnaire was used as tool to collect data from(362) respondents who were chosen by the simple random sampling method ,appropriate statistical methods were used to process the data.The study concluded that:Youth have a very high awareness of the indicators of achieving gender equality as on goal of sustainable development through their awareness of the concept of gender,the arithmetic averages ranged between (1.374- 2.026).And the majority of young people with a general average (1.887) believe that gender equality means a situation in which men and women enjoy equal rights, in the educational field with general average of (1.374): Increasing women`s participation in higher education, and in the field of health and life with general average (2.026).In the political sphere with general average (1.856).And in the field of economic empowerment with a general average of (1.768): Equality between men and women in the workplace, The study recommended a number of theoretical and practical recommendations.
Contribution of Heirarchy Ambiguity and Dysfunctional Boundaries in Predicting Emotional Cutoff among Married Women Who Attend Mental Health Centers
Authors: Al-Tamimi Rasha , Tannous Adel
Published: August 2022

This study aims First, to determine the Levels of the emotional Cutoff, the Dysfunctional Boundaries, and the Hierarchy Ambiguity among  Married Wives Who Attend Mental Health Services Centers in Jordan, Second, to explore the relationship between the Wives Emotional Cutoff and their dysfunctional Boundaries, and the Relationship between the Wives Emotional Cutoff and their hierarchy Ambiguity. Third, to reveal the Contribution of Hierarchy Ambiguity and Dysfunctional Boundaries in predicting emotional Cutoff among the Sample. In order to achieve the Study Goals, it was guided by the descriptive correlational predictive Method, A convenience Sampling Technique was adopted to collect the Data from the Participants consisted of (163) Wives with specific terms, after examining the Psychometric Properties (Validity and Reliability). Data were gathered applying emotional cutoff, dysfunctional boundaries, and hierarchy ambiguity scales developed by the researcher. The Study Results Indicated that the Levels of the Emotional cutoff and the Enmeshment among wives were High, the Disengagement level was Moderate, and a Low Level for Hierarchy Ambiguity. Moreover, the Result Revealed a Positive significant Relationship between the wives` Emotional Cutoff and their dysfunctional Boundaries and hierarchy Ambiguity, also, the Variables of the Enmeshment, Disengagement, and the Influence Strategies were predictors of emotional cutoff among Participants in Row. However, the dimension of ambiguity decision making was not a predictor of emotional cutoff. The study recommends developing preventive and therapeutic programs to increase the awareness with study variables and to treat the Problematic Cases.
Participation in the Elections of the 19th Jordanian Parliament: Incentives and Constraints
Authors: Alazzam Abdelbaset , Al-Shara’a Mohammad
Published: August 2022

Aims: The study aims to reveal the incentives and constraints of the participation in the elections of the 19th Jordanian Parliament.

Methods: A survey was distributed to 840 electors from the study population. This study adopts the analytical descriptive approach.

Results: The results of the study showed that the evaluation of the incentives of the electors' participation came in a medium degree. They were in the following order: first, the axis of “Motivational achievement”, with a high degree; second, the axis of "Striving for needs", with a medium degree; third, the axis of "Integration into participation", with a medium degree; and finally, the axis of "Participation preference", with a medium degree. The evaluations of the constraints of the electors' participation came in a medium degree for all axes, the first of which was the "Economic constraints", followed by the "Political constraints", the “social constraints”, and the "Cultural constraints", respectively. The results also showed that there were no statistically significant differences (α≤0.05) between the field of electoral participation incentives and the study variables, with the exception of the variables: “gender,” age, “education”, and “occupation”. In addition, this study revealed that there were no statistically significant differences between the variables in the field of constraints of the electoral participation and the study variables, with the exception of the two variables: "gender" and "age."

Conclusion: The government and civil society institutions should make participation in the parliamentary elections a supreme national interest, and be based on impartiality, integrity and transparency.
Nonexistence in the Syntactic Intellect: Between Perceptions and Manifestations
Authors: Abu Nawas Omar
Published: August 2022

This study is aimed to investigate the impact of the proposition of nonexistence and its manifestations in the syntactic intellect by considering the syntactic structures attributed to nonexistence, examining the most important related linguistic issues in the linguistic studies of the ancient and modern linguists, analyzing its impact on the codification of structural types in the Arabic language, and its impact on the syntactic structures in terms of perception, performance and communication. The study includes an introduction, a preface and three major topics. The first topic studies nonexistence and syntactic components; the second one tackles the nonexistence and perceptive, interpretive components in the syntactic intellect; and due to the importance of nonexistence in linguistic communication and specifying its standards of, it has been ultimately necessary that the third topic analyzes the impact of nonexistence on the components of linguistic communication. These issues have been investigated by means of a descriptive, analytical method in the light of the essential role that the proposition of nonexistence plays in the syntactic intellect. The study ends with a conclusion confirming the most important findings.
The Role of Palestinian Universities in Enhancing Self-management of Myrters’ Wives and Widows among Their Students and Methods to Developing it
Authors: Adnan M. Najim Munawwar , Khalil S. Abu Daff Mahmoud , Ibrahim H. Salahat Roaa
Published: August 2022

The study aims to identify the role of Palestinian universities in enhancing self-management by their student widows and martyrs’ wives from their point of view, and to reveal the presence of differences between the average estimates of the sample members for this role. The researchers used the descriptive analytical approach and designed a questionnaire consisting of (33) items distributed into four areas. The questionnaire was applied to a sample of (200) student widows and martyrs' wives from Islamic University, Al-Quds Open University, Al-Aqsa University, and Al-Azhar University. The constructivist approach was used in order to suggest ways to develop this role through interviews conducted by the researchers with a number of experts. Among the most important findings of the study are the following: The role of the Palestinian universities practice in promoting self-management among widows and martyrs’ wives had a relative weight (72.44%), i.e., to a large degree, and the areas obtained large degrees, arranged in descending order as follows: personal planning, self-confidence, managing social relations, managing emotions. There are no statistically significant differences between the average degrees of the sample members' estimate of the degree to which Palestinian universities practice their role in promoting self-management among widows and wives of martyrs due to the study variables (university, age, cause of death of the husband), while there are significant ones due to the variables of academic qualification, and the differences are in favor of widows and wives of martyrs whose academic qualifications are postgraduate. The study found a set of ways to develop the role of Palestinian universities in promoting self-management of widows and wives of martyrs.
An Account to n-realization in Standard and Jordanian Arabic
Authors: Jaradat Abdulazeez A.
Published: August 2022

This paper focuses on n-liaison which is a phonological process in Arabic. There are two types of liaison in Arabic: the case of the feminine -t and the -n of the sound masculine plural and the dual. Several proposals have been suggested to account for the (non-)application of t-liaison. It has been proposed that its application is determined by its distribution in its spell-out domain in Jordanian Arabic (Jaradat, to appear), its maximal syntactic projection in Standard Arabic (Abdelghani 2010) and its containing phonological phrase in both varieties (Yasin 2012). As for n-liaison, no previous studies accounted for this process. In this study, following Jaradat (to appear), I will show that n-liaison in Standard Arabic is relatively similar to t-liaison. Its realization and omission is adequately predicted by Phase Theory (Chomsky 2001). Its realization is determined based on its distribution in its spell-out domain: it must be omitted in a spell-out domain-internal position. Otherwise, it must be realized. As for n-liaison in Jordanian Arabic, it cannot be fully explained and predicted by the multiple spell-out algorithm since the -n with the dual form must be realized in all possible distributions. With regard to the sound plural, -n is optionally omitted in a spell-out domain-internal position and obligatorily preserved in final position
Aprendizajes interculturales en el proceso formativo de migrantes venezolanos
Authors: Mera José
Published: August 2022

Intercultural learning that takes place with migrants in border areas should be understood as a resource and not as an obstacle in schools. In recent years, the flow of migrants has increased, especially from Venezuela, who have the right to education. Therefore, the objective of the investigation was to analyze how intercultural learning contributes to the training process of Venezuelan migrant students of the Tomas Arturo Sánchez Educational Institution, residents of the Municipality of Ipiales - Nariño. The research was developed with a qualitative approach, with a research-action design, using the interview and participant observation. Three types of intercultural learning were defined, managed by the teachers of the Tomas Arturo Sánchez Educational Institution in the municipality of Ipiales, with Venezuelan migrant students, which are: Learning in everyday work situations, learning in migration processes, and learning and research with proposals or contributions. didactic. It was established that learning in migration processes and learning and research with proposals or didactic contributions, present greater frequency in their use, as greater acceptance by students, with high mastery of the teacher and high coverage with reference to the total of migrants enrolled in the institution. Finally, new intercultural learning is proposed to help contribute to the training process of Venezuelan migrant students.
Urgensi MP-ASI Pada Ibu Balita Sebagai Upaya Peningkatan Status Gizi Balita
Authors: Asmi A.Syamsinar
Published: August 2022

Pendahuluan: Makanan Pendamping ASI atau MP-ASI merupakan makanan yang diberikan kepada bayi saat usia 6 bulan untuk menunjang kebutuhan pertumbuhan dan perkembangan bayi disamping ASI.
Tujuan: Meningkatkan pengetahuan ibu balita dalam pemberian Makanan Pendamping Asi yang direkomedasikan oleh WHO.
Metode: Menggunakan penyuluhan dan praktek pembuatan MP-ASI . 37 ibu balita.
Hasil: Menunjukkan bahwa pengetahuan ibu mengalami peningkatan tentang Makanan Pendamping ASI dan mengetahui metode baru dalam pembuatan MP-ASI yang benar.
Kesimpulan: Bahwa terjadinya peningkatan pengetahuan ibu balita dalam memberikan Makanan Pendamping ASI yang lebih sehat dan bergizi
Forming ecosystem structure from the perspective of configuration
Authors: Neganov S. A. , Neganova V. P.
Published: August 2022

Aim. The presented study aims to propose an integrated approach to ecosystem structure formation in modern realities.   Tasks. The authors analyze and assess existing research approaches to the formation of ecosystem structure; propose its major components from the perspective of interaction between subjects; briefly formulate conclusions relevant to practical guidance for the managers of platform holders.   Methods. This study uses the methodology of complementarity and relationship marketing, as well as methods for identifying cause-effect relationships, descriptive research, research and historical design.   Results. An analysis of theoretical developments and business practices shows that ecosystem structure is composed not only of entities jointly creating value and having a certain status, role, and contribution of each platform participant. The conceptualization of the construct should consider the interdependence between companies and their activities, making allowance for the many nonlinear interactions that sometimes lead to unexpected, disproportionate consequences. The structural components of an ecosystem are defined in two aspects: in the context of its understanding as a set of integrated entities and from the perspective of the configuration of their interactions. A pool of new questions for future research is proposed.   Conclusions. The rapid platformization of the sectors of the Russian economy and the transition from dual to multilateral market relations with a synergetic effect make it possible to consider the formation of optimal ecosystem architectonics as a key component that needs to be studied and understood in the context of global and national digital transformation. In this regard, the developing business practices of companies are ahead of their scientific and methodological justification. Thus, it is important to study and scientifically substantiate processes that content undergoes. Brief conclusions serve as a basis for making the right management decisions to choose the optimal structure options for a particular ecosystem.