bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship Between the Effectiveness of School Principals in the Communication Process and the Psychological Capital Levels of Teachers During the Covid-19
Authors: KARABAY Aydın , KORUMAZ Mithat , KOCABAŞ Prof. Dr. İbrahim
Published: August 2021

Purpose: This study was conducted to determine the relationship between the effectiveness of school principals in the communication process and the psychological capital of teachers.
Design/Methodology/Approach: The research was conducted in relational research design which is one of the quantitative research approaches. The universe of the study consists of primary, secondary, and high school teachers in Güngören district of Istanbul province. The stratified sampling method was determined as the sampling method and the sample consisted of 353 participants. The Scale of Effectiveness of School Principals in the Communication Process and the Short Form of the Psychological Capital Scale were used as data collection tools. The analysis of the data was executed with a well-known computer program.
Findings: Correlation analysis was conducted to determine the relationship between the two variables of the study, and as a result of the research, a moderate relationship was found between the effectiveness of school principals in the communication process and the psychological capital of teachers. As a result of this, regression analysis was made and it was determined that the effectiveness of school principals in the communication process explained 13% of teachers' psychological capital.
Highlights: As a result of the research, it was recommended to organize practical training for school principals and teachers on the use of digital communication platforms as a result of the pandemic, and to allocate time for psychological capital and communication process during the seminar periods.
«ЗЕЛЕНЫЕ» ПРЕДПОЧТЕНИЯ НЕФТЕГАЗОВЫХ ИНВЕСТОРОВ
Authors: Иванов Николай
Published: August 2021

Проблема изменения климата уверенно приобретает финансовое измерение. Климатические риски для финансовых организаций выходят на первый план при обсуждении обязательств стран в соответствии с Парижским соглашением. В последний год, после объявления Еврокомиссией «Европейского зеленого курса» (European Green Deal) и явственной перспективы введения углеродных пограничных налогов мировые инвестиционные объединения и инициативы заметно усилили свою активность.

Пандемия коронавируса внесла свой вклад в переоценку перспектив традиционной углеводородной энергетики. Например, долгосрочный прогноз развития мировой энергетики компании BP предложил один из наиболее радикальных взглядов на переход мировой энергетической системы на низкоуглеродный путь развития, но причина этого оказалась связанной именно с обрушением мировых рынков в результате пандемии. В отличие от авторов других долгосрочных прогнозов, BP заложила в свой прогноз вероятность второй волны распространения коронавируса и связанных с ней локдаунов, что должно было привести к дополнительному спаду потребления энергоносителей на мировых рынках. Окажется ли вторая волна столь же разрушительной для рынков, как первая – пока неясно, но возможным следствием таких прогнозов может стать необратимое изменение отношения инвесторов к ископаемым энергоресурсам. Сигналы к этому звучат всё явственнее.

Все больше стран объявляют национальные цели по достижению климатической нейтральности к 2050 году. Все больше крупнейших инвесторов объявляют об изменении стратегии инвестирования и отказе от вложений в высокорисковые углеводородные активы. Как говорится в заявлении крупнейшей инвестиционной компании Black Rock , климатические риски – это финансовые риски.

Российским компаниям необходимо внимательно отслеживать перемены настроения крупнейших мировых инвесторов. Потому что тенденция декарбонизации мировых финансов уже выглядит необратимой и климатические финансовые риски могут в скором времени оказаться чрезмерными.
Enhancement of High Strength Concrete Performance By Utilising Nano Waste Paper Sludge Ash
Authors:   Institute for Infrastructure Engineering and Sustainable Management, Faculty of Civil Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia, Newman Aidan , Halim Nuradila Izzaty ,   Institute for Infrastructure Engineering and Sustainable Management, Faculty of Civil Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia, Muhd Sidek Muhd Norhasri ,   Faculty of Civil Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia, Mohd Saman Hamidah ,   Faculty of Civil Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia, Alisibramulisi Anizahyati ,   Faculty of Civil Engineering, Universiti Teknologi MARA, 40450 Shah Alam, Selangor, Malaysia
Published: August 2021

High strength concrete (HSC) is an amazing breakthrough in the history of construction material. Due to its high strength, durability, and economic value, it has been used in large-scale construction with a unique structure design not achievable by conventional concrete. However, HSC uses a high amount of cement powder which contributes to its overall strength. However, it will require high cement consumption and increases carbon dioxide emission. Waste paper sludge ash (WPSA) is utilised in cement and has improved concrete properties. Nano engineered WPSA might further enhance HSC capabilities. This research focused on the physical and fresh properties of HSC with partial replacement of nano-engineered WPSA to cement through experimental investigation. The HSC produced in this research has a targeted strength of more than 40MPa with a fixed water-cement ratio of 0.2. The WPSA was oven-dried and was sieved to a particle size of 212 micrometers. Then, it was milled until a nano-size particle is obtained. The nano WPSA is used to replace cement in the HSC mix with a replacement percentage of 1%, 3%, 5%, 7%, and 10%. The new properties of the concrete were measured by conducting the flow table test, and the physical property was determined by conducting the compressive test. Compressive tests were conducted for 1, 3, 7, 14, and 28 days with a cube sample size of 50mm x 50mm x 50mm. This research shows that 1% of nano WPSA replacement tends to improve the compressive strength of the HSC concrete by 10.7% compared to the control sample. On the other hand, the 1% replacement of nano WPSA in HSC did not affect the concrete's workability compared to the control sample. The conventional HSC properties were improved with less usage of cement with the use of WPSA.
Theoretical Investigation of the Quasi-ring C–H…π Interactions
Authors:   Faculty of Applied Sciences, Universiti Teknologi MARA, Perlis Branch Arau Campus, 02600 Arau, Perlis, Lee Sin Ang , Ab Ghani Zaidi ,   Faculty of Applied Sciences, Universiti Teknologi MARA, Perlis Branch Arau Campus, 02600 Arau, Perlis, Yaakob Mohd Hafiz ,   Faculty of Applied Sciences, Universiti Teknologi MARA, Perlis Branch Arau Campus, 02600 Arau, Perlis, Mohamed-Ibrahim Mohamed Ismail ,   School of Distance Education, Universiti Sains Malaysia, 11800 USM, Pulau Pinang
Published: August 2021

The quasi-ring C–H…π interactions have been reported to be responsible for the stability of crystalline materials. The statistical analysis, together with electronic structure calculations in the framework of density functional theory and Moller-Plesset have also provided positive data on the aforementioned interactions. However, improvements can be had in the theoretical calculations, where the basis set convergence is not explored. This is crucial as the interactions are of weak type, reported to be around 4 – 5 kcal mol–1. In this investigation, the idea is to combine the geometry, potential energy surface, and bonding analysis to provide different insights into the interactions. Our results show that the original configurations of the crystals, even with the substitutions of linear chains, are more favorable than the rotated ones. Further calculations are needed to verify the involvements of the π orbitals of the N, C, Cl, S and the d-orbital of Cu, and the s-orbital of hydrogen atoms.
Artikel Review: Potensi Kolagen sebagai Bahan Aktif Sediaan Farmasi
Authors: Rahman Vicania Raisa , Bratadiredja Marline Abdassah , Saptarini, M.Si, Apt. Nyi Mekar
Published: August 2021

Kolagen merupakan protein yang terdapat di kulit, tendon, tulang rawan, dan organ dengan kandungan sekitar 30% atau lebih dari protein total. Saat ini, kolagen telah ditemukan mempunyai 29 jenis dengan struktur dan urutan asam amino yang berbeda. Kolagen mempunyai karakteristik fisikokimia yang baik yaitu bersifat biokompatibel, biodegradable, antigenisitas yang rendah, dan nontoksik dengan berbagai aktivitas yang dapat mendukungnya sebagai sediaan farmasi. Review artikel dilakukan untuk mengumpulkan informasi tentang kolagen yang memiliki berbagai aktivitas sebagai sediaan farmasi. Artikel dikumpulkan dari 107 artikel penelitian. Artikel ini membahas tentang potensi kolagen sebagai sediaan farmasi untuk kesehatan. Hasil yang didapatkan adalah kolagen memiliki banyak peran dalam tubuh sehingga memiliki banyak aktivitas untuk kesehatan, terutama sebagai antiinflamasi, menyembuhkan luka, kondroprotektif, pertumbuhan dan homeostasis kulit, tendon, tulang, otot, dan saraf, dan antikanker. Kolagen sangat mempengaruhi tubuh dan dapat dijadikan sediaan farmasi sebagai suplemen, kosmetik, ataupun scaffolding material untuk kesehatan.
Review: Penerapan Metode Single-Minute Exchange of Dies Sebagai Upaya Peningkatan Produktivitas Kerja Di Industri Farmasi
Authors: Maharani Dian Amalia , Musfiroh Ida
Published: August 2021

Perusahaan industri farmasi yang semakin berkembang secara umum harus dapat menciptakan proses yang efektif dan efisien dalam produksi. Adapun pendekatan yang dapat diupayakan dalam mereduksi waktu set up produksi dengan menggunakan salah satu metode yang termasuk lean manufacturing system yaitu metode Single Minute of Exchange Die (SMED) dimana tujuan dari metode ini yaitu meminimalkan waktu set up. Metode yang digunakan adalah penyelusuran literatur secara elektronik diberbagai jurnal internasional maupun nasional yang diakses dari situs Google Scholar dan ScienceDirect dengan kata kunci “Penerapan Metode Single Minute Exchange of Dies (SMED) di Industri dan Lean Manufacturing System (LMS). Penelusuran literatur yang bersumber data primer diperoleh dari jurnal yang kemudian dilakukan skrining jurnal yang diterbitkan selama 10 tahun terakhir sebagai kriteria. Hasil kajian pustaka yang diambil dari beberapa literatur dengan menggunakan metode SMED di perusahaan industri dalam proses produksi. Dimana perbandingan waktu sebelum improvement dan setelah improvement waktu setup atau changeover dengan metode SMED memiliki penurunan yang cukup signifikan dengan persentase sebesar 39,97 %. Sehingga hasil yang telah diperoleh perlu diperhatikan oleh perusahaan-perusahaan industri terutama industri farmasi sehingga metode tersebut dapat diterapkan dalam pelaksanaan proses produksi untuk meningkatkan prokduktivitas perusahaan..
Neuroprotective effects of arbutin against oxygen and glucose deprivation-induced oxidative stress and neuroinflammation in rat cortical neurons
Authors: Tan Jingjing , Yadav Manoj Kumar , Devi Sushma , Kumar Manish
Published: August 2021

In this study, the neuroprotective potential of arbutin (100 µmol L−1) pre-treatment and post-treatment against oxygen/ glucose deprivation (OGD) and reoxygenation (R) induced ischemic injury in cultured rat cortical neurons was explored. The OGD (60 min) and reoxygenation (24 h) treatment significantly (p < 0.001) compromised the antioxidant defence in cultured neurons. Subsequently, an increase (p < 0.001) in lipid peroxidation and inflammatory cytokines (tumour necrosis factor-α and nuclear factor kappa-B) declined neuron survival. In pre- and post-condition experiments, treatment with arbutin enhanced both survival (p < 0.01) and integrity (p < 0.05) of cultured neurons. Results showed that arbutin protects (p < 0.05) against peroxidative changes, inflammation, and enhanced the antioxidant activity (e.g., glutathione, superoxide dismutase and catalase) in cultured neurons subjected to OGD/R. It can be inferred that arbutin could protect against ischemic injuries and stroke. The anti-ischemic activity of arbutin can arrest post-stroke damage to the brain.
Update on glasdegib in acute myeloid leukemia – broadening horizons of Hedgehog pathway inhibitors
Authors: Fersing Cyril , Mathias Fanny
Published: August 2021

Numerous new emerging therapies, including oral targeted chemotherapies, have recently entered the therapeutic arsenal against acute myeloid leukemia (AML). The significant shift toward the use of these novel therapeutics, administered either alone or in combination with intensive or low-intensity chemotherapy, changes the prospects for the control of this disease, especially for elderly patients. Glasdegib, an oral Hedgehog pathway inhibitor, showed satisfactory response rates associated with moderate toxicity and less early mortality than standard induction regimens in this population. It was approved in November 2018 by the FDA and in June 2020 by the EMA for use in combination with low-dose cytarabine as a treatment of newly-diagnosed AML in patients aged ≥ 75 and/or unfit for intensive induction chemotherapy. The current paper proposes an extensive, up-to-date review of the preclinical and clinical development of glasdegib. Elements of its routine clinical use and the landscape of ongoing clinical trials are also stated.
Initiation of insulin therapy in patients with type 2 diabetes: An observational study
Authors: Zerovnik Spela , Kos Mitja , Locatelli Igor
Published: August 2021

The aim of the study was to assess the initiation of insulin therapy in patients with type 2 diabetes using health claims data on prescription medicines. The study evaluated time to insulin initiation and prescribing patterns of other anti-diabetic medicines before and after insulin initiation. Five years after starting non-insulin antidiabetic therapy, 6.4 % of patients were prescribed insulin, which is substantially lower compared to other similar studies. Among all patients who initiated insulin therapy in 2013, 30 % did not continue any other antidiabetic therapy. However, this proportion was lowered to 20 % in 2018. Before insulin initiation in 2018, metformin was prescribed in only 67 % of patients and sulfonylureas in 78 % of patients. Moreover, metformin and sulfonylureas were discontinued after insulin initiation in 26 and 37 % of patients, resp. More attention should be paid to the continuation of oral anti-diabetics, particularly metformin, after insulin initiation.
Effect of feed pellet size and tank water level on growth performance in juvenile pikeperch, Sander lucioperca (L.), reared in a recirculating system
Authors: Kozłowski Michał , Piotrowska Iwona , Szczepkowska Bożena
Published: August 2021

Three 28-day experiments were performed to assess the impact of two sinking feed pellet sizes (0.5–1.0 and 0.9–1.6 mm for experiment I, 0.9–1.6 and 1.3–2.0 mm for experiment II, and 1.3–2.0 and 1.6–2.4 mm for experiment III) and two tank water levels (0.50 and 0.65 m) on the growth performance of juvenile pikeperch of different mean initial body weights in experiment I, II, III respectively (1.1 ± 0.1 g, 5.1 ± 0.2 g, 16.6 ± 0.5 g) at different ages (67, 102, and 137 days post hatch). Two-factor analysis of variance showed that the growth of pikeperch was positively correlated with feed pellet size in experiment I, both feed pellet size and water level in experiment II, and water level in experiment III. The feed pellet sizes of 0.9–1.6 and 1.3–2.0 mm at body weights of 1.1 g and 5.1 g, respectively, are recommended to promote more efficient pikeperch growth rates. In the case of pikeperch with a body weight of 16.6 g, the feed pellet size was less important than the tank water level.
How do You Feel in Virtual Environments? The Role of Emotions and Openness Trait Over Creative Performance
Authors: Agnoli Sergio , Zenari Sofia , Mastria Serena , Corazza Giovanni Emanuele
Published: August 2021

In the Dynamic Creativity Framework creativity is defined as a context-embedded phenomenon requiring potential originality and effectiveness. This definition indicates that the environmental conditions embedding the creative process have fundamental impact on the process itself and its outcomes. In particular, Virtual environments (VEs) are emerging as everyday contexts for a large part of the world population, affecting behaviors and feelings. VEs have been demonstrated to affect creative performance in several ways, even if the psychological mechanisms at the basis of the different modifications in the creative behavior are far from being completely explained. The aim of this study was to explore the influence of different types of VEs on creative performance, with a specific focus on participants’ emotional reactions and on their individual differences in the Openness personality trait. A total of 22 participants were exposed to four different types of environments: a real room environment (RE), a control virtual environment (CVE) resembling the physical characteristics of the RE, a positive virtual environment (PVE) and a negative virtual environment (NVE). Participants were free to explore each environment for two minutes, then they were asked to perform an Alternative Uses Task for five minutes, to measure divergent thinking performance. Openness and affective reactions in each environment were measured in all participants. Results showed that Openness was associated with higher originality of responses and that this effect was particularly significant in PVE. Importantly, the type of environment interacted significantly with participants’ affective reactions in explaining their creative performance, revealing that an increase of ideas originality was associated with an increase of positive affect, emerging as a consequence of experiencing a PVE. Affective reactions to VEs, in combination with individual differences in term of Openness, thus emerge as one of the possible explicatory mechanisms of the impact of virtual reality on creative performance.
Hypersensitivity pneumonitis – acceptance of the diagnosis
Authors: Hogea Patricia , Tudorache Emanuela , Vastag Zsolt , Gârjoabă Andrada , Oancea Cristian
Published: August 2021

Hypersensitivity pneumonia (HP) is an inflammatory lung syndrome due to repetitive exposure to small organic particles. The etiological agents of the disease are diverse and can be represented by fungi, bacteria, small molecule chemical compounds, as well as proteins from animals or insects. We present the case of a 25-year-old male, who was admitted to our Pulmonology Clinic for the following symptoms: morning cough with mucosal sputum for about 2 years, moderate exertional dyspnea (mMRC 3) started for 2 months, weight loss of about 6 kg in the past 5 months and fatigue. Clinical examination revealed bilateral mid- basal crackling rales. Chest high-resolution computed tomography (HRCT) (multiple micronodular opacities, diffuse contoured, bilaterally disseminated), lung function tests (restrictive ventilatory dysfunction with decreased carbon monoxide diffusing capacity), bronchoalveolar lavage (BAL) (lymphocyte alveolitis) and serological tests (positive antibodies for pigeon heathers and dejections) pointed to the diagnosis of hypersensitivity pneumonitis. It was recommended to avoid exposure to pigeons, as the patient was a pigeon breeder. Prednisone treatment was initiated. The general condition of the patient 1 month after diagnosis had improved, the evolution being good under treatment.
Cardiac sarcoidosis: Case report and review of the literature
Authors: Tirziu Cristina Manuela , Zeca Vlad-Cristian , Tirziu Razvan Cristian
Published: August 2021

Sarcoidosis is a rare inflammatory multisystem disease, frequently underdiagnosed and often clinically silent, with a negative prognosis on patient’s survival should the cardiovascular system be involved. This occurs not only due to the direct involvement of the heart and blood vessels but also due to associated organ dysfunctions, most commonly pulmonary sarcoidosis. Cardiac sarcoidosis typically manifests as either conduction disturbances or, less commonly, as tachy- or bradyarrhythmia, sometimes even with signs and/or symptoms of heart failure. In this article, we present the case of a relatively young female patient with few significant comorbidities, who presented to the emergency department for palpitations with a high heart rate, which ultimately turned out to be caused by sustained ventricular tachycardia. The diagnostic steps undertaken thereafter reveal an underlying pulmonary sarcoidosis with cardiac involvement.
EKSISTENSI SENI HIAS RUMAH TRADISIONAL KUDUS
Authors: Suharson Arif , Dharsono Dharsono , Sunarto Bambang , Prihatin Nanik Sri
Published: August 2021

This study aims to understand the existence of Kudus traditional house decorative art that is formed in conjunction with the culture that enters the cultural life of the Kudus people. The presence of decorative art has an important meaning for the community because it is closely related to the noble values that become a learning vehicle for the next generation. Decorative art in Kudus traditional house made with a variety of decorative diversity that is behind it is a form of strong cultural perspective. The decorative art is deliberately made to have beautiful forms of stilisasi, magnificent but also related to the meaning of symbols. Grounded research with three steps of activity simultaneously, namely:  data reduction, data presentation, and verification or withdrawal of conclusions with inter-pretative model analysis conducted to produce valid research. As a result of human culture, the phenomenon of artifacts is certainly inseparable from the sociocultural context in art. The decorative art of Kudus traditional house characterized by coastal culture was born with the strengthening of socio-economic progress of the community with the concept of "gusjigang" “bagus, ngaji, and dagang” that upholds the values of teachings in Islam.Penelitian ini memiliki tujuan untuk memahami eksistensi seni hias rumah tradisional Kudus yang terbentuk bersamaan dengan budaya yang masuk dalam kehidupan budaya masyarakat Kudus. Kehadiran seni hias memiliki arti penting bagi masyarakat karena berkaitan erat dengan nilai-nilai luhur yang menjadi wahana pembelajaran bagi generasi penerusnya. Seni hias pada rumah tradisional Kudus yang dibuat dengan keberagaman ragam hias yang melatarbelakanginya merupakan wujud perspektif budaya yang kuat. Seni hiasnya sengaja dibuat agar memiliki bentuk-bentuk stilasi yang indah, megah, tetapi juga berkaitan dengan makna simbol. Pendekatan grounded research dengan tiga langkah kegiatan secara bersamaan, yaitu: reduksi data, penyajian data, dan verifikasi atau penarikan simpulan dengan  analisis model interpretatif dilakukan untuk menghasilkan penelitian yang valid. Sebagai hasil kebudayaan manusia, fenomena artefak ini sudah barang tentu tidak dapat dipisahkan dari konteks sosiokultural dalam berkeseniannya. Seni hias rumah tradisioal Kudus yang bercirikan budaya pesisiran lahir dengan menguatnya kemajuan sosial ekonomi masyarakat dengan konsep “gusjigang” “bagus, ngaji, dan dagang” yang memegang teguh nilai-nilai ajaran dalam agama Islam.
Firefighters occupational exposure assessment: a systematic literature review
Authors: Teixeira Tatiana , Dias Isabel , Santos Joana , Bustos Denisse , Guedes J.C.
Published: August 2021

Introduction: Over the years, the evolution of forest fires has occurred as a result of the evolution of the human species. However, forest fires are still a major challenge for society, placing firefighters with greater occupational exposure. The present study has as main objective to carry out a systematic review of the literature on the main techniques and variables for assessing the occupational exposure of firefighters, during the fight against forest fires.Methodology: The systematic review utilised The Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statementmethodology. This methodology was applied in the Scopus, Web of Science, Pubmed and Academic Search Complete databases with different keywords. The review will include articles written in English only. Results: In the present study, 34 articles were included, in which it was found that exposure to smoking is the most studied variable, and it was in 2019 that a greater evolution of studies in this area of research was observed. Regarding the variables, the studies were organised in groups. Here it is possible to check the different variables selected by the authors and the methods and equipment applied.Discussion: The fact that firefighters carry out their tasks in diverse scenarios and extreme conditions has hindered the application of innovative equipment. It is necessary to combine different variables and equipment for the assessment of occupational exposure. However, it is not always possible to develop this type of equipment in order to be inserted from the user's perspective, from the perspective of the environment, where it will be applied, and from an economic perspective, making it difficult to effectively apply it in the field. Conclusion: As future perspectives, it is recommended that new variables are introduced together, in order to improve the assessment of occupational exposure, namely, through the use of carbon monoxide (CO) and lactate assessment.
Fatigue detection through physiological assessment during real-life occupational situations: Preliminary results
Authors: Bustos D. , Guedes J.C. , Pratas P. , Vaz M.P. , Costa J.C. Torres , Fernandes R.J. , Baptista J. Santos
Published: August 2021

Background: Fatigue is a significant health and safety-related problem among workers. In general, it decreases performance and physical strength, causing incidents and accidents in operational situations. During military activities, soldiers often encounter severe conditions, which combined lead to fatigue manifestations affecting their health and performance. Continuous monitoring of their overall health status would prevent its adverse effects. Objective: This work aimed to present the preliminary results of a retrospective assessment of military training physiological recordings using an alert-based fatigue detection algorithm to validate its accurate functioning. Methods: Three case studies from soldiers participating in military training tests were recruited for evaluation. The referred algorithm was developed to manage fatigue through the combined assessment of physiological variables and determine different fatigue levels warnings to advisetimely interventions and prevent potential health impact. Each examined case included the continuous recording of heart rate, breathing rate and core temperature. The algorithm translated physiological sensory data into minute alarms according to fatigue levels determined through the conjunction of normative and related research criteria. Results and Discussion: Outcomes revealed that the algorithm could evidence the different stages of training and the resulting physical demands on soldiers using their physiological response throughout the exercises. Retrieved fatigue alarms showed the high physiological cost of military practices and helped to overview the impact of each training period. Finally, results also demonstrated the importance of individual and contextualised assessment for accurately characterise the subject's fatigue status. Conclusions: It is concluded that the developed decision model can improve the management of real-time fatigue, allowing early detection of potential indicators of further physical impairments. Furthermore, it can lead to the enhancement of work-rest cycles, not only for tactical personnel but also for any safety-sensitive occupation. For future work, its validity will be tested through more participants, and other variableswill be added to improve its accuracy.
The role of resveratrol in hepatotoxicity caused by methotrexate
Authors: ÖZGÖÇMEN Meltem , YEŞİLOT Şükriye
Published: August 2021

Methotrexate is an immunosuppressive and antineoplastic drug that may induce hepatotoxicity. Resveratrol is a compound that has a protective effect thanks to its antioxidant role. In present study was aimed to investigate posibble protective effects of resveratrol in methotrexate induced hepatotoxicity. Eighteen Wistar Albino rats were equally divided into three groups: Control, Methotrexate, Methotrexate + Resveratrol. After a single dose of methotrexate (15 mg/kg, i.p.), resveratrol (10 mg/kg, orally) was applied for 7 days. Fallowing 7 days, rats were sacrificed. Histopathological (H-E staining), immunohistochemical (Tumor Necrosis Factor Alpha, inducible Nitric Oxide Synthases, Nuclear Factor Kappa) and biochemical (Total Oxidant Status, Total antioxidants Status and Oxidative Stress Index) analyses were assayed in liver tissue samples. Additionally, Aspartate Aminotransferase, Alanine Aminotransferase, Gamma Glutamyl Transferase and Total Biluribin activities were assayed in serum samples for biochemical analyses. Normal liver tissues were observed in control groups. Histopatholocigal changes, high staining of Tumor Necrosis Factor Alpha, inducible Nitric Oxide Synthases, Nuclear Factor Kappa, increasing levels of tissue Total Oxidant Status, Oxidative Stress Index and decreasing levels of tissue Total antioxidants Status were observed in methotrexate groups. Moreover, Aspartate Aminotransferase, Alanine Aminotransferase, Gamma Glutamyl Transferase and Total Biluribin levels increased in methotrexate groups too (p<0.05). However, these findings were lower in the Methotrexate + Resveratrol groups (p<0.05). In this study were observed that oxidant levels could increase after methotrexate applied in the liver, whereas resveratrol alleviated effects of hepatotoxicity by histopathological, immunohistochemical and biochemical analyses. However, molecular studies are needed to clearly understand mechanism of resveratrol.
ДИСТАНЦІЙНЕ НАВЧАННЯ МАТЕМАТИКИ В СУЧАСНИХ УМОВАХ ПАНДЕМІЇ ІЗ ВИКОРИСТАННЯМ НАВЧАЛЬНОГО СЕРЕДОВИЩА JETIQ
Authors: Тютюнник Оксана , Крупський Ярослав
Published: August 2021

Статтю присвячено з’ясуванню особливостей використання навчального середовища JetIQ для роботи студентів під час дистанційного навчання в умовах карантинних обмежень. У ній акцентовано увагу на можливостях JetIQ як для студентів так і для викладачів при викладанні вищої математики. Встановлено переваги й недолік окремих видів самостійної діяльності студентів в умовах карантинних обмежень. Також розписано основні модулі системи, які допомагають викладачеві в організації дистанційного навчання.
ПРАКСЕОЛОГІЧНА СПРЯМОВАНІСТЬ ФОРМУВАННЯ ПРОФЕСІЙНОЇ ПІДГОТОВКИ МАЙБУТНІХ УЧИТЕЛІВ ПОЧАТКОВИХ КЛАСІВ
Authors: Василиків Іван
Published: August 2021

У статті розглядається питання професійної підготовки майбутніх учителів початкових класів, шляхи її вдосконалення та оптимізації. Було вирішено, що підхід, розроблений в контексті ідеї створення праксеологічного навчального середовища, має особливе значення для вдосконалення професійної підготовки майбутніх учителів початкових класів. Висвітлено сутність, зміст та структура таких педагогічних категорій, як: “праксеологічний підхід”, “праксеологія”. Дослідження розкриває сутність функцій праксеологічного підхіду та аналізує його взаємозв’язок у праксеологічному навчальному середовищі для професійного розвитку вчителів початкових класів у майбутньому. Конкретний аналіз загальнонаукових концепцій, таких як праксеологічний підхід, розглядається в контексті професійного розвитку майбутнього вчителя початкових класів. Слід зазначити, що праксеологічний підхід формує та розвиває праксеологічні компетенції майбутнього вчителя початкових класів, такі як здатність планувати, організовувати та оцінювати якість своїх навчальних та професійних досягнень.
НОВІ ПІДХОДИ ДО ВИКОРИСТАННЯ ІНСТРУМЕНТІВ НАВЧАННЯ В УМОВАХ ДИСТАНЦІЙНОЇ ОСВІТИ
Authors: Миськів Ірина
Published: August 2021

Стаття присвячена дослідженню проблеми нових підходів до використання педагогічного інструментарію в умовах дистанційної освіти. Українська система освіти постійно змінюється і удосконалюється з огляду на внутрішні та зовнішні детермінанти, піддається корекції зміст і форми її організації задля відповідності кращим світовим та європейським зразкам. Ці процеси вимагають розробки нових стратегій і тактик організації освітнього процесу на всіх його рівнях. Вчені підходять до розгляду проблеми освіти в умовах сьогодення комплексно і цілісно, зокрема обґрунтовують змістову складову і тактичні шляхи удосконалення системи освіти на усіх рівнях.
ТВОРЧА ДІЯЛЬНІСТЬ ТА ЖИТТЄВИЙ ШЛЯХ ПРОВІДНИХ ДИЗАЙНЕРІВ ОДЯГУ СВІТОВОГО РІВНЯ, У КОНТЕКСТІ ПРОЄКЦІЙНОГО САМОВДОСКОНАЛЕННЯ СТУДЕНТІВ ФАКУЛЬТЕТУ ДИЗАЙНУ
Authors: Фещенко Наталія
Published: August 2021

У статті розкривається сутність творчого становлення найбільш відомих дизайнерів, основні віхи їх життя, освіту і схильності, лідерські якості. Основна увага приділена їх мотивам як рушійної творчої сили, їх генезису і реалізації. Креативна складова особи подібна до іскри, що може запалити весь світ потенціалом нових ідей і нового бачення, але цій іскрі вчасно треба допомогти спалахнути, надихнути вірою в успіх і в себе. Саме у цей ключовий момент близькі люди повинні підтримати художника і “підкинути хмизу” у вогонь творчості.

Виокремлено проблеми молоді, які повинні пам’ятати, що в сучасному світі необхідним елементом будь-якої діяльності є комерційний успіх, який визначає подальшу долю будь-якого підприємства, в тому числі і модного будинку. Історія знає багато прикладів феноменально талановитих кутюр’є, наприклад Крістіан Лакруа, що створили безліч цікавих образів і ідей, але, тим не менш, потерпіли комерційний крах. З метою недопущення подібних сценаріїв молоді фахівці повинні бути озброєні необхідним маркетинговим арсеналом впливу на публіку через ЗМІ, соціальні мережі і блоги. Історична тенденція моди зміщується у бік онлайн-сервісів, всіляких колаборацій і аутсорсингових послуг, тим більше це продиктовано нинішніми реаліями глобальних пандемій.
СТРУКТУРНО-ФУНКЦІОНАЛЬНА МОДЕЛЬ СИСТЕМИ ВИХОВАННЯ ГРОМАДЯНСЬКОЇ ВІДПОВІДАЛЬНОСТІ МАЙБУТНІХ ОФІЦЕРІВ ВІЙСЬКОВИХ ЗАКЛАДІВ ВИЩОЇ ОСВІТИ
Authors: Гарбар Євгеній
Published: August 2021

У статті обґрунтовано структурно-функціональну модель системи виховання громадянської відповідальності майбутніх офіцерів військових закладів вищої освіти, складові якої структуровані, взаємопов’язані та мають функціональну орієнтованість. Розроблена структурно-функціональна модель містить чотири взаємопов’язаних складових: змістову, методологічну, організаційну, функціональну. Розкрито змістове наповнення кожної із них. Схарактеризовано, що результативна складова структурно-функціональної моделі системи ГВ МО ВЗВО включає критерії, показники та рівні виховання ГВ МО ВЗВО, діагностичний інструментарій та результат. Доведено, що результатом взаємодії всіх складових структурно-функціональної моделі системи виховання ГВ МО ВЗВО має стати досягнення мети, а саме: підвищення рівня вихованості громадянської відповідальності майбутніх офіцерів військових закладів вищої освіти.
Synthesis of Silver Nanoparticles Using L.Rosa Flowers Extracts: Thermodynamic and Kinetic Studies on the Inhibitoty Effects of Nanoparticles on Creatine Kinase Activity
Authors: Khalaf Riyam Lateef , Ahmed Elham Majeed , Mathkor Thikra Hasan , AL-Zubaidi Hadeel Y.
Published: August 2021

The present work investigates the synthesis of silver nanoparticles (AgNPs) by a biological method using L.Rosa flower extract and silver nitrate as precursors. Optimum conditions of synthesis were studies, such as pH, temperature, concentration of extract, concentration of silver nitrate, and stability with time. Characterization of AgNPs was carried out using UV-visible Spectroscopy, Scanning Electron Microscopy, X-Ray Diffraction, Fourier Transform Infrared and Transmission Electron Microscopy. The biosynthesized AgNPs exhibited inhibitory effects on creatine kinase activity in the sera of patients with myocardial infarction, compared with control subjects. Thermodynamic and kinetic studies of creatine kinase were performed. Further studies on other biological activities were performed to exploit AgNPs full potential. In conclusions, the present study utilize a simple, cheap and environmentally green method to synthesize silver nanoparticles. This single step procedure is more suitable for large scale production as it is rapid and eliminates the elaborate processes employed in the other bio-based protocols (e.g. by using fungi and bacteria).
Investigation of Commuting Graphs for Elements of Order 3 in Certain Leech Lattice Groups
Authors: Azeez Duha Abbas , Aubad Ali Abd
Published: August 2021

Assume that G is a finite group and X is a subset of G. The commuting graph is denoted by С(G,X) and has a set of vertices X with two distinct vertices x, y Î X, being connected together on the condition of xy = yx. In this paper, we investigate the structure of Ϲ(G,X) when G is a particular type of Leech lattice groups, namely Higman–Sims group HS and Janko group J2, along with  X as a G-conjugacy class of elements of order 3. We will pay particular attention to analyze the discs’ structure and determinate the diameters, girths, and clique number for these graphs.
Development of a Job Applicants E-government System Based on Web Mining Classification Methods
Authors: Salman Rasha Hani , Shiltagh Nadia Adnan , Abdullah Mahmood Zaki
Published: August 2021

Governmental establishments are maintaining historical data for job applicants for future analysis of predication, improvement of benefits, profits, and development of organizations and institutions. In e-government, a decision can be made about job seekers after mining in their information that will lead to a beneficial insight. This paper proposes the development and implementation of an applicant's appropriate job prediction system to suit his or her skills using web content classification algorithms (Logit Boost, j48, PART, Hoeffding Tree, Naive Bayes). Furthermore, the results of the classification algorithms are compared based on data sets called "job classification data" sets. Experimental results indicated that the algorithm j48 had the highest precision (94.80%) compared to other algorithms for the aforementioned dataset.
The Utilization of Remote Sensing Imagery and Inverse Distance Weighted Scheme to Simulate the White Oil Effects on Soil Geotechnical Properties
Authors: Jawad L. A. , Abdulwadud H. W. , Hameed Z. A.
Published: August 2021

This research aims to utilize a complementarity of field excavations and laboratory works with spatial analyses techniques for a highly accurate modeling of soil geotechniques properties (i.e. having lower root mean square error value for the spatial interpolation). This was conducted, for a specified area of interest, firstly by adopting spatially sufficient and  well distributed samples (cores). Then, in the second step, a simulation is performed for the variations in properties when soil is contaminated with commonly used industrial material, which is white oil in our case. Cohesive (disturbed and undisturbed) soil samples were obtained from three various locations inside Baghdad University campus in AL-Jadiriya section of Baghdad, Iraq. The unified soil categorization system (USCS) was adopted and soil was categorized  as clayey silt of low plasticity (CL). The cores were contaminated in a synthetically manner using two specified values of white oil (5 and 10 % of its dry weight). Then, the samples were left for three days to certify homogeneity. The results of laboratory tests were enhanced by spatial interpolation mapping, using Inverse Distance Weighted scheme for normal soil samples and those with synthetic pollution. The liquid limit rates were raised slightly as contamination rates raised, while particle size was reduced; in contrary, shear strength parameter values were decreased.
Association of Serum Urotensin-II Levels with Insulin Resistance and Endothelin-I in Type-II Diabetes Mellitus Patients
Authors: Khidhir Sara M. , Mahmud Almas MR , Maulood Ismail M.
Published: August 2021

Urotensin-II (UII), a pluripotent vasoactive cyclic peptide, exhibits the progression of cardiovascular diseases and the glucose metabolic disorder of insulin resistance. Type 2 Diabetes Mellitus (T2DM) is entirely associated with insulin resistance. This study aimed to demonstrate the association of UII with insulin resistance in diabetic and non-diabetic subjects. A total of 73 male and female subjects aged 40-60 years were recruited in this case-control study. They included 35 non- diabetic subjects with a body mass index of (BMI) ≤ 25 and 38 patients with Diabetes Mellitus and BMI ≥ 25. UII levels were assessed beside other vasoactive and clinical parameters.     The results revealed that patients with T2DM had elevated UII and Endothelin-I (ET-I) levels, along with positive correlations with the insulin-resistance marker of Homeostatic Model Assessment for Insulin Resistance (HOMA-IR), blood pressure (BP), fasting blood glucose (FBG), hemoglobin A1c (HbA1C), and asymmetric dimethylarginine (ADMA). Results from stepwise multiple regressions indicated that UII correlated positively with the increases in the levels of serum cholesterol, ET-I, urea, ADMA, and FBG. This study concludes that the increase in UII level has a positive relation with insulin-resistance and the increase in ET-I level. However, UII could inhibit glucose-induced insulin secretion and, hence, can be utilized as a marker for T2DM and its complications through inflammatory microangiopathy.
Authors: Rengkung Jeremy , Cardiah Tita
Published: August 2021

Improved design adjustable desk is related to a table that can be adjusted in position. This table can be used not only in a forward and backward tilted position, but can also be used in left and right side tilted position, so there will be more activities that can be adjusted to the needs and desires of the user. The purpose of this study is to develop a design by providing innovation to the adjustable desk that is already on the market so that the table is more multifunctional when used by users. This study uses an adjustable desk design development method, through data collection from observations, interviews, questionnaires, literature studies, data analysis, and design results. Based on the results of the discussion, it was found that the adjustable desk will add several buffer components to the table for one person with the table surface that can be adjusted according to the user's wishes, in 30o, 45o, 60o, and 90o tilted positions. The tilt position of the table is regulated by a tilt lock to make it easier for users to adjust the position of the table surface by moving the table surface to the desired position. The results of this design development will be a guide for industrial design.

Keywords: Improved design, adjustable desk, Multifunction Furniture
УСТРОЙСТВО ДЛЯ УЛЬТРАЗВУКОВОЙ УСКОРЕННОЙ СУШКИМАКАРОННЫХ ИЗДЕЛИЙВ ПОЛЕ ИНФРАКРАСНОГО ИЗЛУЧЕНИЯ
Authors: Романчиков С.А.
Published: August 2021

Сушка полуфабрикатов макаронных изделий сложный, многоступенчатый и продолжительный процесс, влияющий на качество готовых изделий. Понижение влажности структуры полуфабрикатов макаронных изделий путем увеличения температуры позволяет значительно снизить развитие микробиологических, биохимических и других процессов, а также существенно влияет на сроки хранения готовых изделий. В работе предложено устройство, работа которого основана на принципах высокотемпературной сушки макаронных изделий в поле инфракрасного излучения при непрерывном воздействии ультразвука. Рассмотрены и описаны особенности и преимущества модернизации сушильного шкафа. Предложенное техническое решение позволяет в автоматическом режиме осуществить ускорение процесса сушки, стабилизации и охлаждения полуфабрикатов макаронных изделий, без снижения их качественных характеристик. Модернизация сушильного шкафа обеспечивает ускорение интенсификации скорости высокотемпературной сушки на 24 – 26 %. Работа устройства основано на комплексном использовании ультразвуковых волн и инфракрасного излучения в процессе сушки, стабилизации и охлаждения макаронных полуфабрикатов. Комбинированное воздействие инфракрасного излучения с ультразвуком обеспечивает равномерное распределение влаги между частицами теста, позволяет быстрее увлажнять частицы дисперсной фазы. Это приводит к образованию расслабляющей клейковины, которая вызывает адгезийный и когезийный эффекты и упрочняет «склеивание» теста. Проведенные экспериментальные исследования позволили установить, что основными факторами ускорения сушки полуфабрикатов макаронных изделий являются повышенный коэффициент теплоотдачи и снижение вязкости жидкости от ультразвука. Воздействие ультразвука способствует ускорению перемещения влаги по капиллярам из глубины макаронного теста на поверхность и высокочастотным колебаниям кавитирующих пузырьков газа, находящихся в структуре изделий, которые выдавливают воду из капилляров. В процессе исследования установлены наиболее рациональные значения параметров уровня давления ультразвука и диапазона инфракрасного излучения.
Классификация параметров и показатели качества выбора элементов рентгенооптической системы
Authors: Чичерина Н.В. , Плотникова И.В. , Баус С.С.
Published: August 2021

Научно-образовательный процесс сегодня должен представлять систему, в которой формируется представление об изменяющемся мире, где закрепляются и передаются традиции ответственности перед будущими поколениями за предложенные инженерные решения. В настоящее время при проектировании новых модификаций рентгеновских томографов встает задача подбора значений некоторых параметров, таких как: напряжения на рентгеновской трубке и тип исследуемого материала. Для сокращения времени и трудоемкости проектирования необходимо определить основные параметры и характеристики элементов. В работе большее внимание уделяется ключевым элементам рентгенооптической системы – рентгеновской трубке, детектору рентгеновского излучения, а также геометрических и пространственных размеров самой рентгенооптической системы, так как от выбора правильного расстояния зависит конечное качество теневого изображения, в частности, его резкость, четкость, оптимальный масштаб, возможность воссоздать трехмерное изображение. Определены основные параметры качества изображения, полученных с помощью цифровых детекторов. Получены ключевые характеристики, основные зависимости параметров, показатели качества, а также рекомендации по выбору элементов рентгеновских систем. Показана зависимость размера вокселя детектора от изменения значений расстояний от рентгеновской трубки до оси вращения объекта.
МОДЕЛИРОВАНИЕ РЕГУЛИРУЮЩЕГОУСТРОЙСТВА С ЗАКРУЧИВАНИЕМ ПОТОКА
Authors: Фоминых А.В. , Пономарева О.А. , Ездина А.А.
Published: August 2021

Изложены устройство и работа шлангового регулирующего устройства. При вращении регулирующего элемента из шланга образуются спиралевидные каналы, обеспечивающие закручивание потока проводимой среды. В такой трубе несущая способность и эффективность работы течения возрастает благодаря уменьшению трения и предотвращению осадкообразования.

Предложено регулирующее устройство с закручиванием потока проводимой среды, в котором образуются конфузор и диффузор за счет наклонных к оси регулирующего устройства четырех одинаковых каналов.

На основе уравнения Бернулли разработана методика расчёта регулирующего устройства, позволяющая определить его коэффициент сопротивления и потери давления. В открытом положении регулирующее устройство является полнопроходным и имеет минимальный коэффициент сопротивления.

Выявлено, что в конфузоре вихреобразование, отрыв потока от стенки с одновременным сжатием потока не возникают, поэтому потери давления в конфузоре обусловлены только потерями на трение по длине. Полную потерю давления в диффузоре рассматриваем как сумму потерь давления на трение и расширение (на вихреобразование).

Выполнено моделирование и исследование течения проводимой среды в программном обеспечении SolidWorks 2017. После регулирующего устройства проводимая среда движется по спиралевидным траекториям. Моделирование в программном комплексе SolidWorks 2017 подтверждает закручивание потока предлагаемым регулирующим устройством.