bluuebunny/crossref_metadata_2025 huggingface dataset:
Planned Adaptation of Traditional Dwellings to Extreme Hydrometeorological Events in Indigenous Peoples in the Bolivian Gran Chaco
Authors: Rojas Molina Juan Marco , Zúñiga Libys
Published: May 2023

Las afectaciones ocasionadas por eventos hidrometeorológicos extremos de origen natural como sequías e inundaciones en las viviendas tradicionales en la provincia del Gran Chaco en Bolivia son frecuentes. En ellas inciden las técnicas de construcción usadas, los materiales de construcción empleados, la localización y el diseño de las viviendas, porque no resisten a las amenazas de dichos eventos extremos. Estos aspectos comprometen el hábitat de las poblaciones que las ocupan. Es por ello que esta investigación propone desarrollar desde las bases teóricas de la adaptación planificada como componente de la resiliencia urbano-territorial, la mejora de los sistemas socio- ambientales ante los efectos de los eventos hidrometeorológicos extremos a través de dichas viviendas tradicionales. Es desde la investigación cualitativa que se apoya esta pesquisa para reconocer variables y atributos apoyados desde los enfoques interdisciplinar y sistémico. Los mismos que permiten conectar la relación entre las afectaciones climáticas y los pueblos originarios, buscando desde la práctica social la mejora de las viviendas mediante soluciones ingeniería amparadas en un grupo de regulaciones territoriales en el ámbito rural, así como en la construcción de políticas públicas desde el ente regulador correspondiente.
MTest: a bootstrap test for multicollinearity
Authors: Morales Oñate Víctor , Morales-Oñate Bolívar
Published: May 2023

A nonparametric test based on bootstrap for detecting multicollinearity is proposed: MTest. This test gives statistical support to two of the most famous methods for detecting multicollinearity in applied work: Klein’s rule and Variance Inflation Factor (VIF for essential multicollinearity). As part of the procedure, MTest generates a bootstrap distribution for the coefficient of determination which: i) lets the researcher assess multicollinearity by setting a statistical significance "alfa", or more precisely, an achieved significance level (ASL) for a given threshold, ii) using a pairwise Kolmogorov-Smirnov (KS) test, establishes a guide for an educated removal of variables that are causing multicollinearity. In order to show the benefits of MTest, the procedure is computationally implemented in a function for linear regression models. This function is tested in numerical experiments that match the expected results. Finally, this paper makes an application of MTest to real data known to have multicollinearity problems and successfully detects multicollinearity with a given ASL.
Determinantes del Uso de Efectivo en América Latina
Authors: Delgado Olga , Barrera Vivero Jorge
Published: May 2023

Este documento caracteriza el uso de efectivo en América Latina. Se utilizó la encuesta Global Findex, base de datos del Banco Mundial, para modelar la influencia de diversos factores en la probabilidad de uso de efectivo, mediante un modelo de regresión binaria. El principal hallazgo es que la población femenina, con educación básica, en condiciones de pobreza y desempleo es más propensa a utilizar efectivo en sus transacciones, es decir, que el grado educativo, el nivel de ingresos y el empleo formal influyen en el uso de efectivo.
Pengaruh Latihan Variasi Knee Tuck Jump Terhadap Peningkatan Tinggi Loncatan Pada Siswa Ekstrakurikuler Bola Voli Putra SMP Negeri 2 Kota Bengkulu
Authors: Syahputra Raka , Permadi Andes , Deliyanto
Published: May 2023

Abstract
This study aimed to investigate the effectiveness of knee tuck jump variations on the jump height of male volleyball students’ extracurricular at SMP Negeri 2 Bengkulu City. The method of this study utilized an experimental method. The design of this study used a one group pretest-posttest design. By given the knee tuck jump variation exercise treatment to the sample of 30 people. The instrument for measure jump height was the vertical jump. The data analysis technique in this study used the t-test formula, with a significant level of = 0.05. The results of the study obtained that t arithmetic = 9.00 t table = 1.697. The calculation of the results stated that the value of t arithmetic was 9.00 > t table 1.697 with a level of = 0.05. In conclusion, there was a significant effect of knee tuck jump variations in the form of the jump height of male volleyball extracurricular students at SMP Negeri 2 Bengkulu City.
Keywords: Volleyball, Knee Tuck Jump, High Jump
Hubungan Siklus Menstruasi Terhadap Perfomance Atlet Atletik Lompat Jauh Putri PPLP Provinsi Bengkulu
Authors: Eben Ezer Pasaribu Rio , Yarmani  , Raibowo Septian
Published: May 2023

Abstract
The problem in this study is that female long jump athletes often feel a decrease in performance during menstruation, this study examines the relationship between the menstrual cycle and the performance of female long jump athletes. While the purpose of the study was to determine whether or not there was a relationship between the menstrual cycle and the performance of female long jump athletes. This research method is quantitative. The population of this study were 20 female long jump athletes from PPLP Bengkulu Province. The data obtained by the results of the study with the correlation test obtained the rᵪᵧ= 0.912 >  0.444. It can be concluded that there is a relationship between the menstrual cycle and the performance of female long jump athletes in PPLP Bengkulu Province. 
 Keywords: Athletics, Long Jump, Menstrual Cycle,  Performance
Desain Aplikasi Pencarian Jasa Fotografer (Capturar) dengan Menggunakan Metode Lean UX
Authors: Novialdi T  , Reski Mai Candra  , Muhammad Affandes  , Pizaini
Published: May 2023

Fotografi sebagai bagian dari industri kreatif Indonesia merupakan sebuah industri yang mendorong penggunaan kreativitas individu. Fotografi juga berkembang seiring dengan bertambahnya manfaat fotografi di dalam kehidupan manusia. Pada dasarnya, fotografi dapat berhubungan dengan semua aspek industri karena kebutuhan foto dapat dijadikan sebagai dokumen penting. Perkembangan digital membuat pencarian barang dan jasa secara online sering ditemukan. Namun, pencarian jasa fotografer masih kurang maksimal karena belum adanya aplikasi khusus yang digunakan oleh fotografer dan pencari jasa fotografer.  Pencarian fotografer yang dilakukan saat ini menggunakan metode konvensional, yaitu dengan mencari fotografer melalui rekomendasi teman ataupun keluarga serta melalui sosial media yang tidak diperuntukkan khusus pencarian jasa fotografer. Tujuan penelitian ini adalah untuk merancang desain prototipe aplikasi pencarian jasa fotografer berdasarkan aspek user interface (UI) dan user experience (UX). Penelitian menggunakan metode Lean UX yang terdiri dari 4 tahapan yaitu, Declare Assumptions, Create an Minimum Viable Product, Run an Experiment dan Feedback and Research yang menghasilkan asumsi permasalahan, rancangan prototipe, eksperimen internal dan pengujian usability. Hasil akhir penelitian ini adalah prototipe yang dibangun menggunakan aplikasi Figma. Prototipe telah diuji kepada 25 responden menggunakan pengujian System Usability Scale (SUS) yang menghasilkan nilai 82.
Cost-minimization analysis of HYQVIA® in the treatment of primary immunodeficiency disease (PID) and secondary immunodeficiency disease (SID) in Italy
Authors: Ravasio Roberto , Ripoli Silvia
Published: May 2023

Background: Primary (PID) or secondary (SID) immunodeficiencies are diseases caused by quantitative and/or functional alterations of the different mechanisms involved in the innate and adaptive immune response. This economic evaluation was conducted to compare the cost of treatment of HYQVIA® (hyaluronidase-facilitated subcutaneous infusion of immunoglobulin, fSCIG) compared to intravenous immunoglobulin (IVIG) or subcutaneous immunoglobulin (SCIG), currently reimbursed in Italy, in the treatment of PIDs or SIDs.
Methods: A cost-minimisation analysis was carried out, considering the hospital’s perspective. The direct medical costs (cost of immunoglobulins and cost of administration) were assessed. The analysis was conducted considering one year (52 weeks) time horizon. The reference population included adult patients with PID with impaired antibody production or adult patients with SID with severe or recurrent infections, ineffective antimicrobial treatment and documented specific antibody defect (PSAF) or serum IgG level < 4 g/L.
Results: In the maintenance treatment of PID, HYQVIA® (€ 20,020.00) was the therapeutic alternative with the lowest mean annual cost compared to HIZENTRA® (€ 22,165.19) and VENITAL® (€ 24,967.68). Moreover, in the maintenance treatment of SIDs, HYQVIA® (€ 17,160.00) was the cost-saving therapeutic alternative compared to VENITAL® (€ 22,107.68). A sensitivity analysis confirmed the base case results.
Conclusion: Due to lower costs of administration and different scheme of administration, HYQVIA® was a cost-saving alternative to SCIG e IVIG in the treatment of PID and to IVIG in the treatment of SID
Elit Erkek Futbol, Basketbol ve Hentbol Oyuncularının Denge ve Fonksiyonellik Performanslarının Karşılaştırılması: Kesitsel Bir Çalışma
Authors: Haksever Bünyamin , Summakoğulları Sergen , Soylu Çağlar , Demir Pervin
Published: May 2023

Bu çalışma, futbol, basketbol ve hentbol branşlarında elit seviyede mücadele eden sporcuların denge ve fonksiyonellik bakımından performanslarını karşılaştırmak amacıyla planlanmıştır. Çalışmaya elit seviyede mücadele eden 66 (22 futbol, 22 hentbol ve 22 basketbol) erkek sporcu dahil edilmiştir. Çalışmaya katılan sporcuların dinamik denge performansları Y Denge Testi, statik denge performansları Standing Stork Testi, çeviklik performansı T Çeviklik Testi, esneklik performansları Otur-uzan Esneklik Testi ile değerlendirilirken sıçrama performansı değerlendirmelerinde ise yatay sıçrama için Tek Bacak Sıçrama testi ve dikey sıçrama performansı için VertiMetric cihazı kullanılmıştır. Çalışma sonucunda dikey sıçrama, yatay sıçrama dinamik denge ve statik denge performanslarında dominant ve non-dominant tarafta gruplar arasında anlamlı fark bulunurken (p<0.05) çeviklik ve esneklik performansında branşlar arasında anlamlı fark bulunmamıştır. Aynı zamanda futbol ve hentbol sporcularının dinamik denge performansının basketbol sporcularına göre daha iyi olduğu, basketbol sporcularının çift bacak ve her iki taraf tek bacak dikey sıçrama gücünün ve yatay sıçrama performansının diğer branşlara göre daha yüksek olduğu bulunmuştur. Her spor branşı kendi içerisinde spora özgü spesifik hareketler ve performans parametreleri barındırır ancak denge ve fonksiyonellik performansı bütün spor branşlarında başarı için sahip olunması gereken özelliklerdir. Bu nedenle sporcuların antrenman programları içerisinde denge ve fonksiyonellik becerilerinin geliştirilmesi için branşa özgü çalışmalar eklenmesi gerektiği önerilmektedir.
Rethinking the Republic of Letters
Authors:   , Scholten Koen
Published: May 2023

Rethinking the Republic of Letters offers a revisionist look at the historiography of the Republic of Letters and the European, early modern community of learning. It suggests a new approach by conceptualising the learned world as an imagined community, since the members did not know all their peers. These learned communities formed through distinct memory cultures and the representation and identification with collective identities. Rethinking the Republic of Letters looks at early modern biographical dictionaries (vitae), eulogies, letters, travelogues, and funerary monuments of early modern learned man to trace the (re)formation of these communities. It thereby offers a novel perspective on early modern learned communities: the Republics of Letters.
PELATIHAN PENGGUNAAN MEDIA SOSIAL SEBAGAI LANGKAH PENCEGAHAN KEKERASAN TERHADAP PEREMPUAN DAN ANAK DI DESA PASIR GOMBONG
Authors: Setyaningsih Apris , Al Ramadhan M Fakhran
Published: May 2023

Violence against women and children has a number that tends to increase. Judging from the cases that are increasing every day. In preventing violence to woman and children the state and the people must prevent, protect, and take actions in accordance with the laws. This is the background for the author to make training related to the prevention of violence against women and children in the village of Pasir Gombong. Content creation training in the form of posters using Canva which will then be distributed in strategic places around the author's domicile and accompanied by education about violence against women and children. The purpose of this activity is through training on creating creative content on social media for young people, which is expected to help local communities participate in preventing violence against women and children. The implementation method is by using community education, training, and consultation.
EDUKASI DALAM MENINGKATKAN KEMAMPUAN KOMUNIKASI INTERPERSONAL ANTARA SISWA TERHADAP GURU Di MI Al-HIDAYAH SEGARJAYA
Authors: Sangadah Iftitah , Primasari Winda , Maysaroh Nurlaila
Published: May 2023

Many problems experienced by students in communicating. This is because students have different communication skills. Many problems experienced by students in communicating. This is because students have different communication skills. In this study, the research used educational methods to improve interpersonal communication in grade 1 to grade 3 students at MI Al Hidayah Segar Jaya Dusun Kali Asin 1, Batu Jaya sub-district. This education aims to provide knowledge about the importance of good and polite communication with friends and older people. With this education there are also changes in students at Mi Al-Hidayah, many students have applied the material provided.
PELATIHAN PERHITUNGAN HARGA POKOK PRODUKSI UMKM DI DUSUN KRAJAN 1B
Authors: Nabila Siti , Risa Nurma , Rusham Rusham
Published: May 2023

The confusion of the SMEs (Micro, Small and Medium Enterprises) in Kutagandok Krajan 1B village is very clear. When asked Perilla how to determine the selling price of the products they will produce. The confusion of MSME actors stems from not knowing exactly how much the production costs of the products they have produced. This service activity aims to train MSME actors in Kutagandok Krajan 1B village in terms of determining the cost of production of the products they have produced, so that MSME actors can determine the selling price that will affect the profits or losses of MSME actors in the Kutagandok Krajan IB village. There are three methods used in this service activity, namely the method of lecture method, training methods, and discussion methods. The results of this service activity will provide insight and understanding to MSME actors in Kutagandok Krajan IB village about calculating production costs. This insight and understanding is reflected in the discussion method. In the discussion method, there will be many MSME actors who will ask questions about material that has not been understood, thus showing the enthusiasm of MSME actors for training in calculating production costs which is quite high.
PELATIHAN PENCATATAN PEMBUKUAN SEDERHANA BAGI UMKM TERASI JEMBRET DI DUSUN KARANGMULYA
Authors: Haryani Sri , Yuniarti Tatik , Saepudin Saepudin
Published: May 2023

The problem that is often faced by the surrounding community, especially for Micro, Small and Medium Enterprises (MSMEs), is the difficulty in evaluating their business. Because many SMEs only focus on their business, they don't think about the importance of simple bookkeeping. The purpose of making this bookkeeping training is that students are expected to be able to channel some of their knowledge to be taught to MSMEs who do not understand how to do bookkeeping and MSMEs who are not familiar with bookkeeping in the preparation of simple financial reports, so that any problems that exist in MSMEs can be resolved and develop their business with a focus . . The implementation methods in bookkeeping training are: Socialization, Learning/Discussion, Training and Evaluation. Where this activity begins with socialization to MSMEs about the importance of bookkeeping, then a discussion session in the form of learning materials and guidance through videos is held followed by training in simple bookkeeping for MSMEs in Karangmulya Hamlet, Segarjaya Village. The results obtained from this activity are that the Terasi Jembret MSME actors have begun to understand simple bookkeeping training, and need to be carried out regularly so that it can be carried out better, and gives positive results knowing that the evaluation of their business experiences a gain or loss from recording profit financial statements. losses and can measure the ability of its business to be sustainable in the future.
PELATIHAN DESAIN SOLIDWORKS 2D & 3D KEPADA SISWA MENENGAH KEJURUAN DI DESA SEGARAN
Authors: Yasa Mahendri Cakra , Budiman Rido , Prihartini Sya’baningrum
Published: May 2023

The world of education is currently facing an industrial revolution, for the younger generation it is necessary to prepare in terms of abilities in the computer field. For vocational students, the ability that must be improved is to be skilled at using computers to design as a development in drawing technique subjects. Based on the school's mission, one of which is to strive for the quality of vocational education services in accordance with the demands of the business community and the industrial world, so training on computer drawing techniques needs to be added specifically. One of the developments required is skillful use of SolidWork software. Students can improve their skills in using the software by participating in training held by Mechanical Engineering students at UNISMA BEKASI. SolidWork's training method uses direct instruction, which includes orientation activities, presentations, structured exercises, guided exercises, and independent exercises.
PENINGKATAN KAPASITAS APARATUR PEMERINTAH DESA KUTAJAYA
Authors: Basri Ardana Rahmat Diffa , Muslimah Alfiana Indah , Ash Shabah Musyaffa Amin
Published: May 2023

The problems that exixt in the Kutajaya village government are that optimal administration has not been implemented, this can be seen in the incomplete population administration in kutajaya village and the issuance of decrees to community empowerment institutions and youth organizations. The method of implementation in the activity program is public education, a socialization seminar, in which the author collaborates with university education academics as resource persons to be able to provide material related to increasing the capacity of the village apparatus. With this socialization seminar, village officials can bring the knowledge provided by professional speakers in their fields. The results provided from the program are able to provide understanding to village officials regarding administration and community empowerment. It can be concluded that increasing the capacity of the village apparatus is very important for strengthening human resources in the village government. With efforts to increase the capacity of village government officials, it can bring human resources of village apparatus to optimize performance and be able to see the potential that exists in rural communities in kutajaya village. So it is very important for village officials to be able to improve their skills. Thus increasing the village government apparatus is an important part for the village government to be carried out by the village head as an effort to improve the skills pf the village apparatus.
MEMBANGUN KEUNGGULAN BERSAING DENGAN PEMASARAN SYARIAH
Authors: Rahayu Fatik , Hardjanti Adiati , Sukmanti Adi , Yusran Fadhel Audia , Wijanarko Khansa Fara , Gunarto Gunarto
Published: May 2023

This community service activity aims to increase understanding and skills on how to compete by implementing sharia marketing strategies. Understanding this strategy is very important as a first step in successful marketing in the future considering that there are great opportunities for implementing sharia marketing in Indonesia, where the majority of the population is Muslim. PKM activities are carried out using education, training and discussion/consultation methods. Submission of material followed by practice solving cases and continued with discussion and consultation of problems faced by participants as small business actors considered appropriate to the characteristics of PKM participants. The participants of this activity were 25 students of the Cordova College of Entrepreneurship. The activity was carried out effectively because it succeeded in increasing the participants' knowledge, understanding and skills regarding the concept of Sharia marketing.
PELATIHAN PEMBUATAN MEDIA PEMBELAJARAN BERBASIS ANDROID
Authors: Baharuddin Baharuddin , Kuswandi Aos , Suharyat Yayat
Published: May 2023

The purpose of this service is to provide teachers with an understanding of how important Android-based media learning is in supporting the learning process. This community service program has the goal of conducting learning media training that can be used as an option for teachers and can be implemented in the learning process at school. Community service is carried out by providing training on making learning media based on Android applications in the learning process in the classroom for teachers in Tamansari Village, Setu District, Bekasi Regency. The service participants are the school heads and teachers from various levels in Tamansari Village, Setu District, Bekasi Regency. Dedication and limited facilities and infrastructure, 10 principals and 20 teachers were taken. The training was held at the Tamansari Village Office, Setu District, Bekasi Regency for 1 day on August 11, 2022. The implementation of community service can be categorized as successful in terms of the participation of participants and village officials who really helped carry out the activity, considering the target of 30 participants who were invited to attend as many as 30 people. Participants were very enthusiastic in participating in this service activity because it was a very new knowledge and made it easy to carry out learning, in addition to contemporary learning as well as developing Android-based learning media that they would use in learning in their respective schools. The participants' responses and responses to the service activities carried out stated that from the quality of the presenters, the quality of the modules was very good and they hoped that there would be ongoing training for special teachers in their schools who could be said to be still behind with technology.
PELATIHAN TATA KELOLA PENYEMBELIHAN HALAL DAN THOYYIB DI MUSHOLA AL-IKHLASH KECAMATAN CIBUGEL, SUMEDANG
Authors: Putra Purnama , Hambali Yoyo , Hasibuan Akmal Rizki , Ash Shabah4 Musyafa Amin , Rahmawati Rafika , Mulyadi Acep , Suprihatin Suprihatin , Asiah Siti , Supriyanto Agus
Published: May 2023

Idhul Adha is a holiday for Muslims around the world where on that day there is an activity, namely the slaughter of sacrificial animals, but there are issues and focuses that are faced first, the lack of knowledge of the general public about halal slaughter, second, namely the management of packaging and processing Qurbani meat. Community Service at the Faculty of Islamic Religion focuses on Eid al-Adha/qurban governance, especially in the management of sacrificial animals starting from slaughtering to packaging and processing of the meat. Community service activities related to halal slaughter training and qurban meat packaging and processing governance aim to improve skills and knowledge about halal slaughtering and management of qurban meat packaging and processing for the Sukaraja Village Community and the Management of the Al-ikhlas Mushala RT.06/RW.02. The Community Service Team of the Faculty of Islamic Religion, Islamic University 45 (UNISMA) uses the training method. This activity was carried out offline by providing descriptions and examples indoors for the next stage to be practiced together with the residents of the Al-ikhlas Cibugel Mosque, Sumedang. The results of the implementation of community service activities which were manifested in the form of training on the slaughter and processing of halal and thoyyib sacrificial animals for the management of the Al-Ikhlas Mosque in Cibugel, Sumedang as a whole ran smoothly and were able to increase public understanding. This is evidenced by the enthusiasm, active involvement, contentment in the discussions and practices of most of the management. Another impact that the community received from this activity was in the form of increasing the community's sense of belonging to their religion and nation, dividing some of the qurbani meat, increasing community sensitivity and the spirit of mutual cooperation which in Sundanese terms is known as the concept of sabilulungan.
Comportamiento de la notificación de enfermedades huérfanas al Sivigila, Colombia, 2019
Authors: González Toloza Nidia Esperanza
Published: May 2023

Introducción: las enfermedades huérfanas corresponden a condiciones de salud crónicamente debilitantes de muy baja frecuencia, en Colombia la fuente oficial de información de enfermedades huérfanas es el Registro Nacional de Pacientes con Enfermedades Huérfanas administrado por el Ministerio de Salud y Protección Social. En este documento se pretende describir el comportamiento de la notificación de enfermedades huérfanas al Sivigila en Colombia durante el 2019. Materiales y métodos: informe descriptivo retrospectivo de los resultados de la vigilancia rutinaria de enfermedades huérfanas – raras en Colombia durante 2019, los datos fueron recolectados por las Instituciones Prestadoras de Servicios de Salud y las Empresas Administradoras de Planes de Beneficios en el nivel local (municipios y distritos) y notificados al Instituto Nacional de Salud a través del Sistema Nacional de Vigilancia en Salud Pública – Sivigila. El análisis de los datos se realizó mediante estadística descriptiva en términos de lugar y tiempo, se incluyó la variable nombre de la enfermedad para establecer diferencias en la distribución de las enfermedades notificadas con mayor frecuencia. Resultados: durante 2019 se notificaron a Sivigila 17 743 casos de enfermedades huérfanas, las entidades territoriales que notificaron el mayor número de casos fueron Bogotá, Antioquia y Cali, las enfermedades notificadas con mayor frecuencia fueron: esclerosis múltiple, déficit congénito del factor VIII, enfermedad de Von Willebrand, síndrome de Guillain-Barre y drepanocitosis. Conclusión: el aumento en la notificación de enfermedades huérfanas en Colombia puede estar relacionado con el fortalecimiento del Sivigila y con la expedición de normatividad nacional que establece la notificación como requisito para el recobro de tecnologías en salud no financiadas con recursos de la UPC.
La malaria en Colombia, la antesala a la eliminación
Authors: Ferro Mendez Carolina
Published: May 2023

Introducción: la malaria es una enfermedad febril aguda, causada por parásitos del género Plasmodium spp, que puede generar desde cuadros asintomáticos y sintomáticos leves hasta la muerte. Es un problema de salud pública, en Colombia, ya que hay focos de alta transmisión. En este estudio se realizó un análisis del comportamiento del evento durante el 2019, el año de preparación en el país para la eliminación de la malaria. Materiales y métodos: se analizó la base de datos del Sistema Nacional de Vigilancia en Salud Pública – Sivigila. Se realizó una descripción de las variables demográficas y básicas de interés del evento; se calcularon frecuencias absolutas, incidencias y análisis bivariados; se realizaron análisis de tendencia basándose en la elaboración de canales endémicos. Resultados: en 2019 se notificaron 80 415 casos de malaria, el 98,3 % clasificado como malaria no complicada y prevaleció la infección por P. falciparum con el 51,1 % de los casos; el 44,6 % de casos se presentó en afrocolombianos y el 22,2 % en indígenas. Se confirmaron 3 muertes por malaria, causadas por P. vivax, una de ellas en menor de cinco años. El país se encontró en situación de brote y se obtuvo un Índice Parasitario Anual (IPA) de 10,01 casos por cada 1 000 habitantes en riesgo. El 67,0 % de los casos procede de la región Pacífica, el municipio de Quibdó – Chocó fue el que más casos de malaria notificó (8,4 %), seguido de Tierralta – Córdoba (6,6 %) y Tibú – Norte de Santander (5,4 %). Conclusión: el 2019 fue un año hiper endémico para malaria, se registró uno de los IPA más altos durante los últimos años y la mayor proporción de casos se presentó e el Pacífico. Predominó la infección por P. falciparum como se observó en 2010 y 2016, también años epidémicos.
Transporte aéreo de pasajeros asintomáticos desde la zona afectada por COVID-19 en Wuhan, China a Bogotá DC, Colombia. Febrero 2020 “Una experiencia de país”
Authors: Rizo Tello Víctor Z. , Díaz Moreno Jorge L. , Prieto Alvarado Franklyn E. , Walteros Acero Diana M. , González Duarte Maritza A. , Huguet Aragón Claudia M. , Sánchez Ayala Brian I. , Alarcón Cruz Ángela P. , Madero Reales Javier A.
Published: May 2023

Antecedentes: la COVID-19 es considerada una Emergencia de Salud Pública de Interés Internacional desde el 30 de enero de 2020. Debido a la evolución de la epidemia en Wuhan y a la necesidad de proteger a connacionales residentes en China, Colombia realiza su repatriación en un vuelo humanitario bajo estrictos protocolos de bioseguridad, para evitar la introducción del virus al país. Objetivo: describir la preparación, el traslado y el desembarco de los connacionales para la prevención y control del riesgo durante el transporte de pasajeros colombianos asintomáticos para COVID-19 desde Wuhan a Colombia en febrero de 2020. Métodos: elaboración del plan de trabajo integral que consideró el riesgo biológico y eventos clínicos; selección del personal y de la aeronave; configuración interna de la cabina; abordaje del riesgo durante el traslado (tamizaje y control), condiciones de bienestar y seguridad al interior de la aeronave y protocolo para el desembarque y transporte al sitio final de cuarentena. Resultados: delimitación de las zonas de riesgo en la cabina, para la ubicación de la tripulación y pasajeros, traslado de 25 pasajeros: 17 colombianos, 3 mexicanos y 5 españoles; ejecución de protocolos de seguridad de forma adecuada por las tripulaciones de vuelo, médica y de los pasajeros. La aeronave se adaptó a lo planeado, no hubo incidentes durante el vuelo, fue activado el protocolo de “emergencia” al descenso, se mantuvo el confort, bioseguridad y seguridad del vuelo en todas sus fases. Conclusión: se realiza el transporte de connacionales asintomáticos, garantizando su bienestar, seguridad y bioseguridad y la de la tripulación médica y de vuelo que ejecutó la misión “Regreso a casa”.
Algorithm for managing patients with papulopustular acne
Authors: Kruglova L. S. , Tamrazova A. V. , Gryazeva N. V. , Stenko A. G.
Published: May 2023

The aim of the study was to study the efficacy and tolerability of the sequential use of the fixed combination of clindamycin + BPO in various clinical situations in real practice. Under our supervision there were 32 patients with mild-to-moderate and severe acne of papulo-pustular acne. Among them, 21 (65.6 %) female patients and 11 (34.4 %) male patients. The patients were divided into two groups: group 1 (teenage acne) of 17 people, group 2 (adult acne) of 15 people. The therapy algorithm included the use of a fixed combination of clindamycin + BPO (Zerkalin Intensive) for 4–5 weeks with a sequential transition to the use of a topical agent with adapalene for 6 months. All patients were prescribed specialized dermatocosmetics on an ongoing basis. As a result of therapy, after a week, there was a significantly significant change in all clinical symptoms of acne. So VAS (comedones) at the end of therapy decreased by 88.9 % (p < 0.01) and by 90.5 % (p < 0.01) in groups 1 and 2, respectively. Similar dynamics was noted in relation to inflammatory elements (papules, pustules). VAS (papules) in groups 1 and 2 decreased by 85.4 % (p < 0.01) and by 88.1 % (p < 0.01), VAS (pustules) – by 100 %. Thus, the use of a fixed combination of clindamycin + BPO causes a high therapeutic effect in relation to all clinical symptoms of acne.
Evaluation of effectiveness of complex therapy for atopic dermatitis in children and adolescents using transcranial magnetic therapy
Authors: Iskra A. S. , Iskra E. L. , Suslova G. A. , Zaslavsky D. V.
Published: May 2023

Today, the development and implementation of modern physiotherapeutic treatment options, including those safe for home use by patients, is promising.

Purpose of the study. Studying the safety and effectiveness of transcranial magnetotherapy with mild and moderate severity of atopic dermatitis.

Material and methods. The study was attended by 104 patients, aged 5 to 16 years, with a prescription of the disease from 2 months to 16 years. Patients were divided into groups: the 1st group received standard therapy, in the 2nd group they combined standard therapy and placebo in physiotherapeutic treatment, patients of the 3rd groups used transcranial therapy in monotherapy, participants of the 4th group were on combined therapy – transcranial magnetotherapy and standard.

Results. According to the study, the effectiveness of transcranial magnetotherapy is based on a positive effect on the state of the central nervous system and its autonomic department, which is accompanied by the relief of clinical symptoms, itching and helps to improve psychoemotional status.

Conclusions. The use of transcranial magnetotherapy in a complex with standard therapy helps to relieve clinical symptoms of atopic dermatitis and the quality of life of patients.
Prevalence of Injuries and Comorbidities among People with Autism Spectrum Disorder
Authors:   Korean Association For Persons With Autism, Sim Boram , Hwang Soo-Hee , Lee Hyejin , Yun Jieun , Lee Jin Yong
Published: May 2023

This study is an initial study providing nationwide statistics regarding the prevalence of injuries and comorbidities in people with Autism Spectrum Disorder (ASD). The prevalence of injuries and comorbidities in pleple with ASD was examined in the National Health Insurance Service (NHIS) data spanning from 2010 to 2019. We found that the prevalence of injuries in people with ASD was not higher than in the general population. However, this had increased steadily over 10 years. The most common comorbidities with ASD were found to be mental and behavioral disorders. Outpatient visits for mental diseases such as schizophrenia and hospitalization for dental treatment were more prevalent than in the general population.
Studying and Teaching Gender-Caste Histories in India: Problems, Possibilities, and Pleasures
Authors: Gupta Charu
Published: May 2023

Amid a larger context of political and social changes in India, this article reflects on a personal-academic trajectory and the problems, possibilities, and pleasures of teaching and researching histories of gender and caste in modern India at the University of Delhi for more than three decades. As a feminist historian, the author first points to some of the limitations in her early years of teaching courses on gender, where she occluded caste as a category of analysis. However, an examination of the conjunctions between anti-caste thought and gender through a Dalit feminist pedagogical lens led to shifts in her curriculum and academic scholarship. The article goes on to discuss how preparing and teaching courses on gender-caste histories pose many challenges in terms of queries from the university administration, curriculum design, pedagogic practices, and student responses. Classroom spaces are highly politicized in India, with pronounced gender, caste, class, and linguistic identities that often overlap with each other, which has implications for teaching and research. Finally, the article deliberates on the creative possibilities of such courses and pedagogical strategies, as students critique the crafting of mainstream history writing, feel drawn to new theoretical tools and methodologies that rely on different archival registers, and question the erasure of caste as an analytic, in the process also making the classroom a more democratic space.
Experiências em Musicoterapia sob a Perspectiva da Música Ubíqua
Authors: Alcântara-Silva Tereza Raquel , Rocha do Nascimento Sandra , Alves Ribeiro Mayara Kelly , Keller Damián
Published: May 2023

Relatamos as estratégias e os procedimentos adotados no desenvolvimento do Programa de musicoterapia para profissionais da saúde (PROMUS). A proposta insere-se no contexto das iniciativas ubimus que visam o incentivo ao bem-estar através da disponibilização e o estudo do impacto do suporte tecnológico em contextos cotidianos. Em particular, atentamos para a utilização de ambientes que previamente não eram considerados como espaços com potencialidade de aplicação musicoterapêutica. Outro aspecto inovador da presente proposta é o reaproveitamento de tecnologia já disponível nas atividades do dia a dia do público-alvo. Essa utilização de tecnologia leve, de baixo custo operativo e compatível com um perfil diverso de potenciais participantes está fortemente alinhada às práticas estabelecidas dentro da comunidade ubimus. Discutimos as implicações desta proposta para a ampliação do vínculo entre ubimus e os usos terapêuticos dos recursos musicais.
Energy-based procedures for seismic fragility analysis of mainshock-damaged buildings
Authors: Pedone Livio , Gentile Roberto , Galasso Carmine , Pampanin Stefano
Published: May 2023

In recent decades, significant research efforts have been devoted to developing fragility and vulnerability models for mainshock-damaged buildings, i.e., depending on the attained damage state after a mainshock ground motion (state-dependent fragility/vulnerability relationships). Displacement-based peak quantities, such as the maximum interstory drift ratio, are widely adopted in fragility analysis to define both engineering demands and structural capacities at the global and/or local levels. However, when considering ground-motion sequences, the use of peak quantities may lead to statistical inconsistencies (e.g., fragility curves’ crossings) due to inadequate consideration of damage accumulation. In this context, energy-based engineering demand parameters (EDPs), explicitly accounting for cumulative damage, can help address this issue. This paper provides an overview of recent findings on the development of aftershock-fragility models of mainshock-damaged buildings. Particular focus is given to state-of-the-art frameworks for fragility analyses based on cumulative damage parameters. Moreover, a literature review on damage indices and energy-based concepts and approaches in earthquake engineering is reported to better understand the main advantages of the mostly adopted energy-based parameters, as well as their limitations. Different refinement levels of seismic response analyses to derive fragility relationships of mainshock-damaged buildings are also discussed. Finally, the benefits of adopting energy-based EDPs rather than, or in addition to, peak quantities in state-dependent fragility analyses are demonstrated on a reinforced concrete frame building. Specifically, a refined lumped plasticity modeling approach is adopted, and sequential cloud-based time-history analyses of a Multi-Degree-of-Freedom (MDoF) model are carried out. The results highlight that energy-based approaches for fragility analysis effectively capture damage accumulation during earthquake sequences without inconsistencies in the obtained statistical models. On the other hand, estimating global or local structural capacity in terms of cumulative EDPs is still challenging. Further experimental data are needed to better calibrate the quantification of energy-based damaged states.
Hyperinsulinemia: an early biomarker of metabolic dysfunction
Authors: Vaidya Rama A. , Desai Sharvari , Moitra Panchali , Salis Sheryl , Agashe Shubhada , Battalwar Rekha , Mehta Anushree , Madan Jagmeet , Kalita Soumik , Udipi Shobha A. , Vaidya Ashok B.
Published: May 2023

Introduction

Hyperinsulinemia in the absence of impaired glucose tolerance and normal HbA1c is considered indicative of pre-diabetes. Very few Indian studies have focused on hyperinsulinemia particularly in young adults. The present study aimed to determine whether hyperinsulinemia may be present despite HbA1c being normal.

Methods

This was a cross–sectional study conducted on adolescents and young adults aged 16-25 years living in Mumbai, India. The participants attended various academic institutions and were those who underwent screening as the first step of a clinical trial for studying the efficacy of almond intake in prediabetes.

Results

Among this young population (n=1313), 4.2% (n=55) of the participants were found to be prediabetic (ADA criteria) and 19.7% of them had HbA1c levels between 5.7%-6.4%. However, almost, 30.5% had hyperinsulinemia inspite of normal blood glucose levels and normal HbA1c. Among those with HbA1c<5.7 (n=533), 10.5% (n=56) participants had fasting insulin>15 mIU/L and a higher percentage (39.4%, n=260) had stimulated insulin above 80 mIU/L. These participants had higher mean anthropometric markers than those with normal fasting and/or stimulated insulin.

Conclusion

Hyperinsulinaemia in the absence of impaired glucose tolerance and normal HbA1c may provide a much earlier indicator of detection for risk of metabolic disease and progression to metabolic syndrome and diabetes mellitus.
Knowledge mapping and current trends of global research on CRISPR in the field of cancer
Authors: Liu Han , Lv Zongwei , Zhang Gong , Wang Xia , Wang Yuan , Wang Kefeng
Published: May 2023

Background: Gene editing tools using clustered regularly interspaced short palindromic repeats (CRISPR) and CRISPR-related systems have revolutionized our understanding of cancer. The purpose of this study was to determine the distribution, collaboration, and direction of cancer research using CRISPR.

Methods: Data from the Web of Science (WoS) Core Collection database were collected from 4,408 cancer publications related to CRISPR from 1 January 2013to 31 December 2022. The obtained data were analyzed using VOSviewer software for citation, co-citation, co-authorship, and co-occurrence analysis.

Results: The number of annual publications has grown steadily over the past decade worldwide. The United States was shown, by far, to be the leading source of cancer publications, citations, and collaborations involving CRISPR than any other country, followed by China. Li Wei (Jilin University, China), and Harvard Medical School (Boston, MA, United States) were the author and institution with the most publications and active collaborations, respectively. The journal with the most contributions was Nature Communications (n = 147) and the journal with the most citations was Nature (n = 12,111). The research direction of oncogenic molecules, mechanisms, and cancer-related gene editing was indicated based on keyword analysis.

Conclusion: The current study has provided a comprehensive overview of cancer research highlights and future trends of CRISPR, combined with a review of CRISPR applications in cancer to summarize and predict research directions and provide guidance to researchers.
Metal interactions of α-synuclein probed by NMR amide-proton exchange
Authors: Gonzalez-Garcia Mario , Fusco Giuliana , De Simone Alfonso
Published: May 2023

The aberrant aggregation of α-synuclein (αS), a disordered protein primarily expressed in neuronal cells, is strongly associated with the underlying mechanisms of Parkinson’s disease. It is now established that αS has a weak affinity for metal ions and that these interactions alter its conformational properties by generally promoting self-assembly into amyloids. Here, we characterised the nature of the conformational changes associated with metal binding by αS using nuclear magnetic resonance (NMR) to measure the exchange of the backbone amide protons at a residue specific resolution. We complemented these experiments with 15N relaxation and chemical shift perturbations to obtain a comprehensive map of the interaction between αS and divalent (Ca2+, Cu2+, Mn2+, and Zn2+) and monovalent (Cu+) metal ions. The data identified specific effects that the individual cations exert on the conformational properties of αS. In particular, binding to calcium and zinc generated a reduction of the protection factors in the C-terminal region of the protein, whereas both Cu(II) and Cu(I) did not alter the amide proton exchange along the αS sequence. Changes in the R2/R1 ratios from 15N relaxation experiments were, however, detected as a result of the interaction between αS and Cu+ or Zn2+, indicating that binding to these metals induces conformational perturbations in distinctive regions of the protein. Collectively our data suggest that multiple mechanisms of enhanced αS aggregation are associated with the binding of the analysed metals.
Inhibitory effects of vaginal Lactobacilli on Candida albicans growth, hyphal formation, biofilm development, and epithelial cell adhesion
Authors: Takano Tomonori , Kudo Hayami , Eguchi Shuhei , Matsumoto Asami , Oka Kentaro , Yamasaki Yukitaka , Takahashi Motomichi , Koshikawa Takuro , Takemura Hiromu , Yamagishi Yuka , Mikamo Hiroshige , Kunishima Hiroyuki
Published: May 2023

Introduction

Antifungal agents are not always efficient in resolving vulvovaginal candidiasis (VVC), a common genital infection caused by the overgrowth of Candida spp., including Candida albicans, or in preventing recurrent infections. Although lactobacilli (which are dominant microorganisms constituting healthy human vaginal microbiota) are important barriers against VVC, the Lactobacillus metabolite concentration needed to suppress VVC is unknown.

Methods

We quantitatively evaluated Lactobacillus metabolite concentrations to determine their effect on Candida spp., including 27 vaginal strains of Lactobacillus crispatus, L. jensenii, L. gasseri, Lacticaseibacillus rhamnosus, and Limosilactobacillus vaginalis, with inhibitory abilities against biofilms of C. albicans clinical isolates.

Results

Lactobacillus culture supernatants suppressed viable fungi by approximately 24%-92% relative to preformed C. albicans biofilms; however, their suppression differed among strains and not species. A moderate negative correlation was found between Lactobacillus lactate production and biofilm formation, but no correlation was observed between hydrogen peroxide production and biofilm formation. Both lactate and hydrogen peroxide were required to suppress C. albicans planktonic cell growth. Lactobacillus strains that significantly inhibited biofilm formation in culture supernatant also inhibited C. albicans adhesion to epithelial cells in an actual live bacterial adhesion competition test.

Discussion

Healthy human microflora and their metabolites may play important roles in the development of new antifungal agent against C. albicans-induced VVC.