bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Figure Legends from Dual Targeting of EGFR and HER3 with MEHD7945A Overcomes Acquired Resistance to EGFR Inhibitors and Radiation
Authors: Huang Shyhmin , Li Chunrong , Armstrong Eric A. , Peet Chimera R. , Saker Jarob , Amler Lukas C. , Sliwkowski Mark X. , Harari Paul M.
Published: April 2023

PDF file - 63KB, Supplementary Figure Legends
Supplementary Figure 2 from Selective Blockade of Matrix Metalloprotease-14 with a Monoclonal Antibody Abrogates Invasion, Angiogenesis, and Tumor Growth in Ovarian Cancer
Authors: Kaimal Rajani , Aljumaily Raid , Tressel Sarah L. , Pradhan Rutika V. , Covic Lidija , Kuliopulos Athan , Zarwan Corrine , Kim Young B. , Sharifi Sheida , Agarwal Anika
Published: April 2023

PDF file - 139K, MMP-14 antibody inhibits catalytic conversion of proMMP-2 to MMP-2 and binds specifically to MMP-14
Supplementary Data 1 from Generation of Prostate Tumor–Initiating Cells Is Associated with Elevation of Reactive Oxygen Species and IL-6/STAT3 Signaling
Authors: Qu Yi , Oyan Anne Margrete , Liu Runhui , Hua Yaping , Zhang Jigang , Hovland Randi , Popa Mihaela , Liu Xiaojun , Brokstad Karl A. , Simon Ronald , Molven Anders , Lin Biaoyang , Zhang Wei-dong , McCormack Emmet , Kalland Karl-Henning , Ke Xi-Song
Published: April 2023

XLS file 30K, Accumulation of chromosomal aberrations in stepwise generated cell lines.
Supplementary Figure Legend from CSF1R Signaling Blockade Stanches Tumor-Infiltrating Myeloid Cells and Improves the Efficacy of Radiotherapy in Prostate Cancer
Authors: Xu Jingying , Escamilla Jemima , Mok Stephen , David John , Priceman Saul , West Brian , Bollag Gideon , McBride William , Wu Lily
Published: April 2023

PDF file - 53K
Supplemental Figure S1 from Mast Cell–Derived Prostaglandin D2 Inhibits Colitis and Colitis-Associated Colon Cancer in Mice
Authors: Iwanaga Koichi , Nakamura Tatsuro , Maeda Shingo , Aritake Kosuke , Hori Masatoshi , Urade Yoshihiro , Ozaki Hiroshi , Murata Takahisa
Published: April 2023

Supplemental Figure S1
Supplementary Figure 2 from Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
Authors: Gutekunst Matthias , Mueller Thomas , Weilbacher Andrea , Dengler Michael A. , Bedke Jens , Kruck Stephan , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 31K, Oct-4 and Noxa determine the general sensitivity of TGCT cells to genotoxic and non-genotoxic agents
Supplementary Figure 1 from Cisplatin Hypersensitivity of Testicular Germ Cell Tumors Is Determined by High Constitutive Noxa Levels Mediated by Oct-4
Authors: Gutekunst Matthias , Mueller Thomas , Weilbacher Andrea , Dengler Michael A. , Bedke Jens , Kruck Stephan , Oren Moshe , Aulitzky Walter E. , van der Kuip Heiko
Published: April 2023

PDF file - 15K, Noxa, Puma and Bim are not cross-regulated
Supplementary Figure 2 from Myeloid WNT7b Mediates the Angiogenic Switch and Metastasis in Breast Cancer
Authors: Yeo Eun-Jin , Cassetta Luca , Qian Bin-Zhi , Lewkowich Ian , Li Jiu-feng , Stefater James A. , Smith April N. , Wiechmann Lisa S. , Wang Yihong , Pollard Jeffrey W. , Lang Richard A.
Published: April 2023

PDF file - 1920K, S2: Assessment of Vegfa and Notch target gene expression in flow sorted vascular endothelial cells.
Supplementary Figure Legend from The Insulin Receptor Negatively Regulates the Action of Pseudomonas Toxin-Based Immunotoxins and Native Pseudomonas Toxin
Authors: Liu Xiu Fen , FitzGerald David J. , Pastan Ira
Published: April 2023

PDF file - 125K
Supplementary Figures 1 - 5 from Notch3 Pathway Alterations in Ovarian Cancer
Authors: Hu Wei , Liu Tao , Ivan Cristina , Sun Yunjie , Huang Jie , Mangala Lingegowda S. , Miyake Takahito , Dalton Heather J. , Pradeep Sunila , Rupaimoole Rajesh , Previs Rebecca A. , Han Hee Dong , Bottsford-Miller Justin , Zand Behrouz , Kang Yu , Pecot Chad V. , Nick Alpa M. , Wu Sherry Y. , Lee Ju-Seog , Sehgal Vasudha , Ram Prahlad , Liu Jinsong , Tucker Susan L. , Lopez-Berestein Gabriel , Baggerly Keith A. , Coleman Robert L. , Sood Anil K.
Published: April 2023

PDF file - 765K, Overall Survival (OS) Analysis in Patients With High-Grade Serous Ovarian Cancer HGS-OvCa (S1); In Vitro Functional Studies of Notch3 siRNA or GSI and combined with Paclitaxel in OvCa Cells (S2); qRT-PCR Analysis of Expression of Gamma-Secretase Complex in Ovarian Cancer Cells (S3); In vitro effects of blocking endocytosis on Jagged-1/Notch3 pathway in cancer cells (S4); In vivo study of Notch3 siRNA in orthotopic mouse models of ovarian cancer (S5).
Supplementary Figure Legend from HTLV-1 bZIP Factor Suppresses Apoptosis by Attenuating the Function of FoxO3a and Altering Its Localization
Authors: Tanaka-Nakanishi Azusa , Yasunaga Jun-ichirou , Takai Ken , Matsuoka Masao
Published: April 2023

PDF file - 75K
Supplementary Figure 3 from Systems Analysis of BCL2 Protein Family Interactions Establishes a Model to Predict Responses to Chemotherapy
Authors: Lindner Andreas U. , Concannon Caoimhín G. , Boukes Gerhardt J. , Cannon Mary D. , Llambi Fabien , Ryan Deborah , Boland Karen , Kehoe Joan , McNamara Deborah A. , Murray Frank , Kay Elaine W. , Hector Suzanne , Green Douglas R. , Huber Heinrich J. , Prehn Jochen H.M.
Published: April 2023

PDF file - 52K, Systems modeling can act as a clinical tool to determine therapeutic windows and to assess adjuvant treatments.
Supplementary Methods , Figure Legends 1-6 from CD40-Mediated Activation of Chronic Lymphocytic Leukemia Cells Promotes Their CD44-Dependent Adhesion to Hyaluronan and Restricts CCL21-Induced Motility
Authors: Girbl Tamara , Hinterseer Elisabeth , Grössinger Eva Melanie , Asslaber Daniela , Oberascher Karin , Weiss Lukas , Hauser-Kronberger Cornelia , Neureiter Daniel , Kerschbaum Hubert , Naor David , Alon Ronen , Greil Richard , Hartmann Tanja Nicole
Published: April 2023

PDF file - 105K
Supplementary Table 2 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: April 2023

XLSX file - 28K, RNA-QC, sequencing, and clinical metadata on the 106 samples sequenced in this study.
Supplementary Table 1 from Global Transcriptome Analysis of Formalin-Fixed Prostate Cancer Specimens Identifies Biomarkers of Disease Recurrence
Authors: Long Qi , Xu Jianpeng , Osunkoya Adeboye O. , Sannigrahi Soma , Johnson Brent A. , Zhou Wei , Gillespie Theresa , Park Jong Y. , Nam Robert K. , Sugar Linda , Stanimirovic Aleksandra , Seth Arun K. , Petros John A. , Moreno Carlos S.
Published: April 2023

XLSX file - 10K, Clinical characteristics of patients analyzed by RNAseq.
Supplementary Figure 1 from Polo-like Kinase 1: A Potential Therapeutic Option in Combination with Conventional Chemotherapy for the Management of Patients with Triple-Negative Breast Cancer
Authors: Maire Virginie , Némati Fariba , Richardson Marion , Vincent-Salomon Anne , Tesson Bruno , Rigaill Guillem , Gravier Eléonore , Marty-Prouvost Bérengère , De Koning Leanne , Lang Guillaume , Gentien David , Dumont Aurélie , Barillot Emmanuel , Marangoni Elisabetta , Decaudin Didier , Roman-Roman Sergio , Pierré Alain , Cruzalegui Francisco , Depil Stéphane , Tucker Gordon C. , Dubois Thierry
Published: April 2023

PDF file - 135K, Expression of PLK2, PLK3 and PLK4 in human breast cancers
Supplementary Methods from Homing of Human B Cells to Lymphoid Organs and B-Cell Lymphoma Engraftment Are Controlled by Cell Adhesion Molecule JAM-C
Authors: Doñate Carmen , Ody Christiane , McKee Thomas , Ruault-Jungblut Sylvie , Fischer Nicolas , Ropraz Patricia , Imhof Beat A. , Matthes Thomas
Published: April 2023

PDF file - 84K, Methods include Flow cytometry analysis, Histological staining of mouse, JAM-B expression analysis, and statistical analysis
Supplementary Figure 1 from Homing of Human B Cells to Lymphoid Organs and B-Cell Lymphoma Engraftment Are Controlled by Cell Adhesion Molecule JAM-C
Authors: Doñate Carmen , Ody Christiane , McKee Thomas , Ruault-Jungblut Sylvie , Fischer Nicolas , Ropraz Patricia , Imhof Beat A. , Matthes Thomas
Published: April 2023

PDF file - 5664K, Controls for human B cell quantification in NOD/SCID mice
Supplementary Figures 1 - 5 from Hypomethylating Therapy in an Aggressive Stroma-Rich Model of Pancreatic Carcinoma
Authors: Shakya Reena , Gonda Tamas , Quante Michael , Salas Martha , Kim Samuel , Brooks Jenna , Hirsch Steffen , Davies Justine , Cullo Angelica , Olive Kenneth , Wang Timothy C. , Szabolcs Matthias , Tycko Benjamin , Ludwig Thomas
Published: April 2023

PDF file - 261K, Reductions in global genomic 5mC in stromal myofibroblasts and malignant epithelial cells in progression from early to late PanIN. DNMT1 levels are reduced in human pancreatic CAFs and are dependent on cellular proliferation. The proliferation index assessed by Ki67 IHC is lower in CAFs than in malignant epithelial cells and is reduced in both components following DAC treatment of the KPC-Brca1 tumors. DAC leads to induction of mRNA expression of interferon response pathway genes. Large areas of sarcomatoid change and loss of CAFs in tumors that have escaped from growth inhibition by DAC.
Supplementary Figure 4 from Tumor Suppressor NF2/Merlin Is a Microtubule Stabilizer
Authors: Smole Zlatko , Thoma Claudio R. , Applegate Kathryn T. , Duda Maria , Gutbrodt Katrin L. , Danuser Gaudenz , Krek Wilhelm
Published: April 2023

PDF file - 1250K, NF2 is a stabilizer of microtubules.
Supplementary Figure S1 from Ex Vivo Expansion of Highly Cytotoxic Human NK Cells by Cocultivation with Irradiated Tumor Cells for Adoptive Immunotherapy
Authors: Lim Seon Ah , Kim Tae-Jin , Lee Jung Eun , Sonn Chung Hee , Kim Kwanghee , Kim Jiyoung , Choi Jong Gwon , Choi Il-Kyu , Yun Chae-Ok , Kim Jae-Hong , Yee Cassian , Kumar Vinay , Lee Kyung-Mi
Published: April 2023

Supplementary Figure S1 PDF file - 29K, Fold expansion of NK cells following co-cultivation of PBMC in IL-2 with irradiated solid tumor (A549, MCF7, Chang, Hela, HT29, MDA-MB-31, SK-BR-3), liquid tumor (CEM, K562, U937, KL-1) and PBMC (allogeneic and autologous) targets are shown
Supplementary Figure 3 from FGF-2 Disrupts Mitotic Stability in Prostate Cancer through the Intracellular Trafficking Protein CEP57
Authors: Cuevas Rolando , Korzeniewski Nina , Tolstov Yanis , Hohenfellner Markus , Duensing Stefan
Published: April 2023

PDF file - 374K, Supernumerary centrioles co-localize with CAP350.
Supplementary Figure 2 from FGF-2 Disrupts Mitotic Stability in Prostate Cancer through the Intracellular Trafficking Protein CEP57
Authors: Cuevas Rolando , Korzeniewski Nina , Tolstov Yanis , Hohenfellner Markus , Duensing Stefan
Published: April 2023

PDF file - 607K, Endogenous and overexpressed CEP57 localize to the centrosome in U-2 OS/centrin-GFP cells.
Supplementary Figure 1 from Phosphorylation of Ribosomal Protein S6 Attenuates DNA Damage and Tumor Suppression during Development of Pancreatic Cancer
Authors: Khalaileh Abed , Dreazen Avigail , Khatib Areej , Apel Roy , Swisa Avital , Kidess-Bassir Norma , Maitra Anirban , Meyuhas Oded , Dor Yuval , Zamir Gideon
Published: April 2023

PDF file - 3639K, Representative images of pancreatic lesions in wild type mice implanted with DMBA, or in Pdx1-Cre; LSL-Kras G12D mice.
Supplementary Table S1 from Arkadia Regulates Tumor Metastasis by Modulation of the TGF-β Pathway
Authors: Briones-Orta Marco A. , Levy Laurence , Madsen Chris D. , Das Debipriya , Erker Yigit , Sahai Erik , Hill Caroline S.
Published: April 2023

Supplementary Table S1 PDF File - 52K, Number of tumors observed in the lungs 20 and 30 days post-injection for parental NCI-H460 cells and clones NCI-H460 WT Ark 1 and NCI H460 Ark 11
Supplementary Figure Legends from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: April 2023

PDF file - 104KB
Supplementary Figure 6 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: April 2023

PDF file - 71KB, Expression of CAF marker by engineered fibroblasts.
Supplementary Figure 5 from Cancer-Associated Fibroblasts Expressing CXCL14 Rely upon NOS1-Derived Nitric Oxide Signaling for Their Tumor-Supporting Properties
Authors: Augsten Martin , Sjöberg Elin , Frings Oliver , Vorrink Sabine U. , Frijhoff Jeroen , Olsson Eleonor , Borg Åke , Östman Arne
Published: April 2023

PDF file - 59KB, NO and glutathione protect CXCL14-fibroblasts.
Supplementary Figure Legend, Methods, Tables 1 - 2 from Earlier Detection of Breast Cancer with Ultrasound Molecular Imaging in a Transgenic Mouse Model
Authors: Bachawal Sunitha V. , Jensen Kristin C. , Lutz Amelie M. , Gambhir Sanjiv S. , Tranquart Francois , Tian Lu , Willmann Jürgen K.
Published: April 2023

PDF file - 116K, Table S1: Summary of Sensitivity, Specificity, Positive and Negative Predictive Values for Differentiating Benign (Normal, Hyperplasia) from Malignant (DCIS, Invasive Cancer) Pathologies Based on Different Imaging Signal Threshold Levels; Table S2a: Summary of Sensitivity, Specificity, Positive and Negative Predictive Values for Differentiating Benign (Normal, Hyperplasia) from DCIS Based on Different Imaging Signal Threshold Levels; Table S2b: Summary of Sensitivity, Specificity, Positive and Negative Predictive Values for Differentiating Benign (Normal, Hyperplasia) from Invasive Cancer Based on Different Imaging Signal Threshold Levels.
Supplementary Figures 1 - 9 from T Lymphocytes Expressing a CD16 Signaling Receptor Exert Antibody-Dependent Cancer Cell Killing
Authors: Kudo Ko , Imai Chihaya , Lorenzini Paolo , Kamiya Takahiro , Kono Koji , Davidoff Andrew M. , Chng Wee Joo , Campana Dario
Published: April 2023

PDF file - 300K, Schematic representation of CD16 chimeric receptors used in this study (S1); Expression of CD16V-BB-Z receptor in T-cell subsets (S2); Relative capacity of CD16V-BB-Z and CD16F-BB-Z receptors to bind Trastuzumab and human IgG (S3); Results of 4-hour in vitro cytotoxicity assays (S4); Cytotoxicity of CD16V-BB-Z T lymphocytes is powerful, specific and is not affected by unbound IgG (S5); T lymphocytes expressing CD16V-BB-Z receptors exert anti-tumor activity in vivo (S6); Functional differences between T lymphocytes expressing CD16VBB-Z and CD16F-BB-Z receptors (S7); Expression of CD16V receptors with different signaling domains (S8); Cytotoxicity mediated by T lymphocytes expressing either CD16VBB-Z or anti-CD19-BB-Z receptors against Daudi cells in the presence of two different concentrations of Rituximab (S9).
Supplementary Figure 4 from Local and Systemic Protumorigenic Effects of Cancer-Associated Fibroblast-Derived GDF15
Authors: Bruzzese Francesca , Hägglöf Christina , Leone Alessandra , Sjöberg Elin , Roca Maria Serena , Kiflemariam Sara , Sjöblom Tobias , Hammarsten Peter , Egevad Lars , Bergh Anders , Östman Arne , Budillon Alfredo , Augsten Martin
Published: April 2023

PDF file - 66KB, Recombinant GDF15/MIC-1 stimulates prostate cancer cell growth and invasion.
Supplementary Methods from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: April 2023

PDF file - 174K, Description of the processing of bone marrow aspirates, as well as the source code for fitting of cell viability measurements into dose/response surfaces.
Supplementary Figure 6 from A Preclinical Assay for Chemosensitivity in Multiple Myeloma
Authors: Khin Zayar P. , Ribeiro Maria L.C. , Jacobson Timothy , Hazlehurst Lori , Perez Lia , Baz Rachid , Shain Kenneth , Silva Ariosto S.
Published: April 2023

PDF file - 40K, Computational modeling of in vivo response to therapy.
Supplementary Table S4 from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: April 2023

Supplementary Table S4 PDF file 59K, Relative gene copy number determined by qPCR analysis (ratio to adjacent normal tissue) of selected eight genes located on chromosome 12q13-15 of individual UHGPS
Supplementary Table S3 from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: April 2023

Supplementary Table S3 PDF file 147K, List of primers
Supplementary Table Legend from Amplification of FRS2 and Activation of FGFR/FRS2 Signaling Pathway in High-Grade Liposarcoma
Authors: Zhang Keqiang , Chu Kevin , Wu Xiwei , Gao Hanlin , Wang Jinhui , Yuan Yate-Ching , Loera Sofia , Ho Kimberley , Wang Yafan , Chow Warren , Un Frank , Chu Peiguo , Yen Yun
Published: April 2023

Supplementary Table Legend PDF file 58K, Legend for Supplementary Tables S1-S5
Supplementary Figure 2 from Taccalonolide Binding to Tubulin Imparts Microtubule Stability and Potent In Vivo Activity
Authors: Risinger A.L. , Li J. , Bennett M.J. , Rohena C.C. , Peng J. , Schriemer D.C. , Mooberry S.L.
Published: April 2023

PDF file - 207K, High magnification electron micrographs (20,000x and 50,000x) of microtubules formed in the presence of 2 mg/ml tubulin with 10 - 30 microM AJ 60 min after tubulin reactions were warmed to 37 degrees C.
Supplementary Table 1 from Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer
Authors: Lin Wan-chi , Rajbhandari Nirakar , Liu Chengbao , Sakamoto Kazuhito , Zhang Qian , Triplett Aleata A. , Batra Surinder K. , Opavsky Rene , Felsher Dean W. , DiMaio Dominick J. , Hollingsworth Michael A. , Morris John P. , Hebrok Matthias , Witkiewicz Agnieszka K. , Brody Jonathan R. , Rui Hallgeir , Wagner Kay-Uwe
Published: April 2023

PDF file - 22K, Immunostaining of selected pancreatic cell lineage markers in ducal and poorly differentiated cancerous lesions of Pdx1-Cre/CAG-tTA/TetOMyc transgenic mice.
Supplementary Methods from Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer
Authors: Lin Wan-chi , Rajbhandari Nirakar , Liu Chengbao , Sakamoto Kazuhito , Zhang Qian , Triplett Aleata A. , Batra Surinder K. , Opavsky Rene , Felsher Dean W. , DiMaio Dominick J. , Hollingsworth Michael A. , Morris John P. , Hebrok Matthias , Witkiewicz Agnieszka K. , Brody Jonathan R. , Rui Hallgeir , Wagner Kay-Uwe
Published: April 2023

PDF file - 28K, Supplemental Methods describing the genetic background of genetically engineered mice and methodology to quantify the expression of Myc in human pancreatic cancer.
Supplementary Figures 1 - 8 from Dormant Cancer Cells Contribute to Residual Disease in a Model of Reversible Pancreatic Cancer
Authors: Lin Wan-chi , Rajbhandari Nirakar , Liu Chengbao , Sakamoto Kazuhito , Zhang Qian , Triplett Aleata A. , Batra Surinder K. , Opavsky Rene , Felsher Dean W. , DiMaio Dominick J. , Hollingsworth Michael A. , Morris John P. , Hebrok Matthias , Witkiewicz Agnieszka K. , Brody Jonathan R. , Rui Hallgeir , Wagner Kay-Uwe
Published: April 2023

PDF file - 719K, Elevated c-MYC expression in human pancreatic cancer cell lines (S1); c-Myc is highly upregulated in a mouse model for pancreatic cancer (S2); Levels of c-Myc (exogenous and endogenous) in ductal and poorly differentiated pancreatic adenocarcinomas that were induced through upregulation of this oncogene in comparison to pancreatic tumors from Pdx1-Cre LSL-KrasG12D animals that carry two wildtype or one mutant allele of p53 (S3); Expression of Muc1, E-Cadherin, Pdx1, and Sox9 in the normal pancreas as well as ductal carcinomas and poorly differentiated carcinomas of transgenic mice expressing exogenous c-Myc (S4); Elevated levels of exogenous c-Myc induces expression of Bax and active Caspase-3 (S5); Ablation of c-Myc expression leads to reduced proliferation, increased expression of p53 as well as autophagy-related protein LC3 but a reduction in the levels of active Caspase-3 (S6); Downregulation of active Caspase-3 and upregulation of LC3 in pancreatic cancers that lack Cdkn2a (S7); Residual cancer cells do not express c-Myc, lack nuclear staining of Ki67 and are TUNEL negative (S8).
Supplementary Methods from G-protein Inactivator RGS6 Mediates Myocardial Cell Apoptosis and Cardiomyopathy Caused By Doxorubicin
Authors: Yang Jianqi , Maity Biswanath , Huang Jie , Gao Zhan , Stewart Adele , Weiss Robert M. , Anderson Mark E. , Fisher Rory A.
Published: April 2023

PDF file - 34K
Supplementary Figures 1 - 4 from G-protein Inactivator RGS6 Mediates Myocardial Cell Apoptosis and Cardiomyopathy Caused By Doxorubicin
Authors: Yang Jianqi , Maity Biswanath , Huang Jie , Gao Zhan , Stewart Adele , Weiss Robert M. , Anderson Mark E. , Fisher Rory A.
Published: April 2023

PDF file - 251K, Figure S1. RGS6 is an essential mediator of Dox-induced increases in p53 in mouse atrium. Figure S2. Quantification of key apoptotic signaling proteins in ventricles of mice treated with Dox. Figure S3. Induction of RGS6 by Dox is transient and requires de novo protein synthesis. Figure S4. Schematic illustration of RGS6-mediated ventricular dysfunction induced by Dox.
Supplementary Table 2 from MAPK Kinase 3 Is a Tumor Suppressor with Reduced Copy Number in Breast Cancer
Authors: MacNeil Adam J. , Jiao Shun-Chang , McEachern Lori A. , Yang Yong Jun , Dennis Amanda , Yu Haiming , Xu Zhaolin , Marshall Jean S. , Lin Tong-Jun
Published: April 2023

XLSX file - 176K, Supplementary Table S2. Gene expression profile for MKK3dn and MKK3ca cells (vs. WT / MDA-MB-468) using the human breast cancer array (Qiagen, PAHS-131A ), summary of n = 3 experiments.
Supplementary Video 5 from Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation
Authors: Martínez-Bosch Neus , Fernández-Barrena Maite G. , Moreno Mireia , Ortiz-Zapater Elena , Munné-Collado Jessica , Iglesias Mar , André Sabine , Gabius Hans-Joachim , Hwang Rosa F. , Poirier Françoise , Navas Carolina , Guerra Carmen , Fernández-Zapico Martin E. , Navarro Pilar
Published: April 2023

AVI file - 2563KB, Supplementary video 5 (Related to Supplementary Figure 4C). Time lapse video microscopy in SK-PC-1 cells infected with a Gal1 shRNA (shGal1#1). Frames were collected every 15 min for 12h.
Supplementary Results, Materials and Methods, Movie Legends, Figures 1 - 7, Tables 1, 3 - 4 from Galectin-1 Drives Pancreatic Carcinogenesis through Stroma Remodeling and Hedgehog Signaling Activation
Authors: Martínez-Bosch Neus , Fernández-Barrena Maite G. , Moreno Mireia , Ortiz-Zapater Elena , Munné-Collado Jessica , Iglesias Mar , André Sabine , Gabius Hans-Joachim , Hwang Rosa F. , Poirier Françoise , Navas Carolina , Guerra Carmen , Fernández-Zapico Martin E. , Navarro Pilar
Published: April 2023

PDF file - 6308KB, Supplementary Figure S1. Gal1 expression in Ela-myc:Gal1 tumors. Supplementary Figure S2. Analysis of ADM-related genes in Ela-myc:Gal1 tumors. Supplementary Figure S3. Effects of Gal1 depletion in necrosis and tumoral stroma in Ela-myc mice. Supplementary Figure S4. Effects of Gal1 downregulation in SK-PC-1 cells in vitro. Supplementary Figure S5. Effects of Gal1 downregulation in PDA cells in vivo.Supplementary Figure S6. PANC-1 xenograft tumor characterization. Supplementary Figure S7. Gal1 downregulation affects genes involved in tumor progression, adhesion and migration. Supplementary Table 1. Tumor invasion and intraperitoneal hemorrhage in Ela-myc:Gal1+/+, Ela-myc:Gal1+/� and Ela-myc:Gal1�/� pancreatic tumors. Supplementary Table 3. Biological Process GO Terms with P < .0005 obtained from the differentially expressed genes in PANC-1 cells control or with low Gal1 levels.
Supplementary Figure Legends from EGFR-Mediated Chromatin Condensation Protects KRAS-Mutant Cancer Cells against Ionizing Radiation
Authors: Wang Meng , Kern Ashley M. , Hülskötter Marieke , Greninger Patricia , Singh Anurag , Pan Yunfeng , Chowdhury Dipanjan , Krause Mechthild , Baumann Michael , Benes Cyril H. , Efstathiou Jason A. , Settleman Jeff , Willers Henning
Published: April 2023

PDF file - 34KB
Supplementary Table 4 from A DNA Methylation Prognostic Signature of Glioblastoma: Identification of NPTX2-PTEN-NF-κB Nexus
Authors: Shukla Sudhanshu , Pia Patric Irene Rosita , Thinagararjan Sivaarumugam , Srinivasan Sujaya , Mondal Baisakhi , Hegde Alangar S. , Chandramouli Bangalore A. , Santosh Vani , Arivazhagan Arimappamagan , Somasundaram Kumaravel
Published: April 2023

XLSX file - 304K, Table ST4: Differentially expressed genes between low and high risk.
Supplementary Figure 3 from Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia
Authors: Bunda Severa , Kang Michelle W. , Sybingco Stephanie S. , Weng Julie , Favre Helene , Shin Danielle H. , Irwin Meredith S. , Loh Mignon L. , Ohh Michael
Published: April 2023

PDF file - 609K, Dasatinib, but not imatinib, markedly inhibits JMML colony formation in the absence or presence of GM-CSF
Supplementary Figure 2 from Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia
Authors: Bunda Severa , Kang Michelle W. , Sybingco Stephanie S. , Weng Julie , Favre Helene , Shin Danielle H. , Irwin Meredith S. , Loh Mignon L. , Ohh Michael
Published: April 2023

PDF file - 4783K, Dasatinib inhibits growth of primary JMML cells from patients with CBL, NF1, NRAS, or PTPN11 mutation in a dose dependent manner
Supplementary Figure 1 from Inhibition of SRC Corrects GM-CSF Hypersensitivity That Underlies Juvenile Myelomonocytic Leukemia
Authors: Bunda Severa , Kang Michelle W. , Sybingco Stephanie S. , Weng Julie , Favre Helene , Shin Danielle H. , Irwin Meredith S. , Loh Mignon L. , Ohh Michael
Published: April 2023

PDF file - 137K, Cbl follows similar temporal course of phosphorylation as GMRβc upon GM-CSF treatment
Supplementary Methods from Targeting the Deregulated Spliceosome Core Machinery in Cancer Cells Triggers mTOR Blockade and Autophagy
Authors: Quidville Virginie , Alsafadi Samar , Goubar Aïcha , Commo Frédéric , Scott Véronique , Pioche-Durieu Catherine , Girault Isabelle , Baconnais Sonia , Le Cam Eric , Lazar Vladimir , Delaloge Suzette , Saghatchian Mahasti , Pautier Patricia , Morice Philippe , Dessen Philippe , Vagner Stéphan , André Fabrice
Published: April 2023

PDF file - 68K
Supplementary Figure 4 from Chemotherapy Alters Monocyte Differentiation to Favor Generation of Cancer-Supporting M2 Macrophages in the Tumor Microenvironment
Authors: Dijkgraaf Eveline M. , Heusinkveld Moniek , Tummers Bart , Vogelpoel Lisa T.C. , Goedemans Renske , Jha Veena , Nortier Johan W.R. , Welters Marij J.P. , Kroep Judith R. , van der Burg Sjoerd H.
Published: April 2023

PDF file - 60K, CAOV3 (an ovarian cancer cell line) was untreated, cultured with tocilizumab or cisplatin. After 24h, intracellular pSTAT-levels were measured by flow cytometry. A) Example of staining pSTAT3 for CAOV3, CAOV3 treated with tocilizumab and CAOV3 treated with cisplatin. B) Geometric mean (background subtracted is depicted. Representative experiment of three experiments. CAOV3 treated with cisplatin shows an increased pSTAT3 and decreased pSTAT1 and 6. Treatment with Tocilizumab reduced STAT3 activation.
Supplementary Figure 7 from RNAi-Mediated Silencing of Myc Transcription Inhibits Stem-like Cell Maintenance and Tumorigenicity in Prostate Cancer
Authors: Civenni Gianluca , Malek Anastasia , Albino Domenico , Garcia-Escudero Ramon , Napoli Sara , Di Marco Stefano , Pinton Sandra , Sarti Manuela , Carbone Giuseppina M. , Catapano Carlo V.
Published: April 2023

PDF file - 100K, Normal prostate epithelial cells (PrECs) were transfected with GL3 and Myc13 siRNA in 12-well plates and counted w/ Neubauer haemocytometer chamber over 9-day period.
Supplementary Figure Legend from Telomere Length and Telomerase Activity Impact the UV Sensitivity Syndrome Xeroderma Pigmentosum C
Authors: Stout Gerdine J. , Blasco Maria A.
Published: April 2023

PDF file - 98K
Supplementary Table 1 from Loss of TGF-β Adaptor β2SP Activates Notch Signaling and SOX9 Expression in Esophageal Adenocarcinoma
Authors: Song Shumei , Maru Dipen M. , Ajani Jaffer A. , Chan Chia-Hsin , Honjo Soichiro , Lin Hui-Kuan , Correa Arlene , Hofstetter Wayne L. , Davila Marta , Stroehlein John , Mishra Lopa
Published: April 2023

PDF file - 740K, Pathological lymph node positivity categorized by SOX9 nuclear staining intensity.
Supplementary Table 1 from CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells
Authors: Jia Jinping , Bosley Allen D. , Thompson Abbey , Hoskins Jason W. , Cheuk Adam , Collins Irene , Parikh Hemang , Xiao Zhen , Ylaya Kris , Dzyadyk Marta , Cozen Wendy , Hernandez Brenda Y. , Lynch Charles F. , Loncarek Jadranka , Altekruse Sean F. , Zhang Lizhi , Westlake Christopher J. , Factor Valentina M. , Thorgeirsson Snorri , Bamlet William R. , Hewitt Stephen M. , Petersen Gloria M. , Andresson Thorkell , Amundadottir Laufey T.
Published: April 2023

XLS file - 29KB, Results from an affinity purification screen searching for CLPTM1L interacting proteins.
Supplementary Figure 5 from CLPTM1L Promotes Growth and Enhances Aneuploidy in Pancreatic Cancer Cells
Authors: Jia Jinping , Bosley Allen D. , Thompson Abbey , Hoskins Jason W. , Cheuk Adam , Collins Irene , Parikh Hemang , Xiao Zhen , Ylaya Kris , Dzyadyk Marta , Cozen Wendy , Hernandez Brenda Y. , Lynch Charles F. , Loncarek Jadranka , Altekruse Sean F. , Zhang Lizhi , Westlake Christopher J. , Factor Valentina M. , Thorgeirsson Snorri , Bamlet William R. , Hewitt Stephen M. , Petersen Gloria M. , Andresson Thorkell , Amundadottir Laufey T.
Published: April 2023

PDF file - 34KB, Knock-down efficiency of MYH9 expression using a specific siRNA.
Supplementary Figures 1 - 7 from Re-engineering Vesicular Stomatitis Virus to Abrogate Neurotoxicity, Circumvent Humoral Immunity, and Enhance Oncolytic Potency
Authors: Muik Alexander , Stubbert Lawton J. , Jahedi Roza Z. , Geiβ Yvonne , Kimpel Janine , Dold Catherine , Tober Reinhard , Volk Andreas , Klein Sabine , Dietrich Ursula , Yadollahi Beta , Falls Theresa , Miletic Hrvoje , Stojdl David , Bell John C. , von Laer Dorothee
Published: April 2023

PDF file - 6330KB, Schematic representation of the recombinant vesicular stomatitis virus (VSV) genomes and its replication potential (S1). rVSV(GP) administration i.c. is associated with marginal inflammation (S2). rVSV(GP) tissue distribution after systemic application is almost consistent with rVSV (S3). rVSV(GP) is comparable to rVSV with regard to its in vitro antitumour efficacy (S4). Replication fitness of rVSV(GP) vs. rVSV in glioma cells (S5). Intratumoural virus administration in s.c. G62 human glioblastoma xenografts leads to productive infection and massive viral burst (S6). U87rfp tumour relapse was not due to OV therapy resistance (S7).
Supplementary Figures 1-6 from Trp53 Inactivation in the Tumor Microenvironment Promotes Tumor Progression by Expanding the Immunosuppressive Lymphoid-like Stromal Network
Authors: Guo Gang , Marrero Luis , Rodriguez Paulo , Del Valle Luis , Ochoa Augusto , Cui Yan
Published: April 2023

Supplementary Figures 1-6 PDF file - 340K, Supplemental Figure S1. Trp53 inactivation in hosts results in an augmented immunotolerant tumor microenvironment. Supplemental Figure S2. Trp53 inactivation in B16F1 tumor bearing hosts does not impose significant effects on the splenic effector T cell function as compared with those in WT tumor bearing mice. Supplemental Figure S3. Tumor associated MDSCs from WT and p53null mice share similar phenotype and suppressor function on per cell basis. Supplemental Figure S4. Analyses of cell surface marker expression profile of MEF from p53null mice. Supplemental Figure S5. Differential differentiation of BM-MDSCs from WT and p53null mice stimulated by different myeloipoietic cytokines. Supplemental Figure S6. SPSCs from p53null mice enhanced BM-MDSCs differentiation in part by suppressing apoptosis of myeloid precursors.
Supplementary Table 1 from ATR Pathway Inhibition Is Synthetically Lethal in Cancer Cells with ERCC1 Deficiency
Authors: Mohni Kareem N. , Kavanaugh Gina M. , Cortez David
Published: April 2023

XLSX file - 201K, Results from the ATRi sensitivity screen.
Supplementary Methods from Differential Effects of RUNX2 on the Androgen Receptor in Prostate Cancer: Synergistic Stimulation of a Gene Set Exemplified by SNAI2 and Subsequent Invasiveness
Authors: Little Gillian H. , Baniwal Sanjeev K. , Adisetiyo Helty , Groshen Susan , Chimge Nyam-Osor , Kim Sun Young , Khalid Omar , Hawes Debra , Jones Jeremy O. , Pinski Jacek , Schones Dustin E. , Frenkel Baruch
Published: April 2023

PDF file - 55KB
Supplementary Material and Methods from CDK4/6 and IGF1 Receptor Inhibitors Synergize to Suppress the Growth of p16INK4A-Deficient Pancreatic Cancers
Authors: Heilmann Andreas M. , Perera Rushika M. , Ecker Veronika , Nicolay Brandon N. , Bardeesy Nabeel , Benes Cyril H. , Dyson Nicholas J.
Published: April 2023

Supplementary Methods with additional experimental procedures
Supplementary Figure 3 from Anti-CD20 Antibody Promotes Cancer Escape via Enrichment of Tumor-Evoked Regulatory B Cells Expressing Low Levels of CD20 and CD137L
Authors: Bodogai Monica , Lee Chang Catalina , Wejksza Katarzyna , Lai Jinping , Merino Maria , Wersto Robert P. , Gress Ronald E. , Chan Andrew C. , Hesdorffer Charles , Biragyn Arya
Published: April 2023

PDF file - 126K, Activity of tBregs is efficiently blocked by CpG-ODN
Supplementary Materials from Erlotinib Prolongs Survival in Pancreatic Cancer by Blocking Gemcitabine-Induced MAPK Signals
Authors: Miyabayashi Koji , Ijichi Hideaki , Mohri Dai , Tada Motohisa , Yamamoto Keisuke , Asaoka Yoshinari , Ikenoue Tsuneo , Tateishi Keisuke , Nakai Yousuke , Isayama Hiroyuki , Morishita Yasuyuki , Omata Masao , Moses Harold L. , Koike Kazuhiko
Published: April 2023

Supplementary Materials PDF file - 91K, Supplementary Methods and Figure Legends
Supplementary Figure 5 from Erlotinib Prolongs Survival in Pancreatic Cancer by Blocking Gemcitabine-Induced MAPK Signals
Authors: Miyabayashi Koji , Ijichi Hideaki , Mohri Dai , Tada Motohisa , Yamamoto Keisuke , Asaoka Yoshinari , Ikenoue Tsuneo , Tateishi Keisuke , Nakai Yousuke , Isayama Hiroyuki , Morishita Yasuyuki , Omata Masao , Moses Harold L. , Koike Kazuhiko
Published: April 2023

Supplementary Figure 5 PDF file - 1755K, Gemcitabine-induced EGFR/ErbB2-MAPK signal activation was a common phenomenon in PDAC and lung cancer cells irrespective of KRAS mutation status and gemcitabine sensitivity.
Supplementary Methods and Figures 1 - 6 from The Planar Cell Polarity Pathway Drives Pathogenesis of Chronic Lymphocytic Leukemia by the Regulation of B-Lymphocyte Migration
Authors: Kaucká Markéta , Plevová Karla , Pavlová Šárka , Janovská Pavlína , Mishra Archana , Verner Jan , Procházková Jiřina , Krejčí Pavel , Kotašková Jana , Ovesná Petra , Tichý Boris , Brychtová Yvona , Doubek Michael , Kozubík Alois , Mayer Jiří , Pospíšilová Šárka , Bryja Vítězslav
Published: April 2023

PDF file - 695K, S. figure 1mRNA from CD19+ cells of healthy individuals. S. figure 2 Expression of Wnt-5a in the samples shown in Fig. 1 was determined by qRT-PCR. S. figure 3 Viability of primary CLL cells stimulated with the indicated compounds have been assessed by the WST1 test. S. figure 4 mRNA from MEC1 cells and from B-cells of healthy individuals was isolated and the expression of the indicated genes was analyzed by real time qRT-PCR. S. figure 5 Flow-cytometric analysis of apoptosis in patient CLL cells used for transplantation. S. Figure 6 Expression of PRICKLE1.
Supplementary Figures 1 - 3 from Predictive Performance of Microarray Gene Signatures: Impact of Tumor Heterogeneity and Multiple Mechanisms of Drug Resistance
Authors: Ng Charlotte K.Y. , Weigelt Britta , A'Hern Roger , Bidard Francois-Clement , Lemetre Christophe , Swanton Charles , Shen Ronglai , Reis-Filho Jorge S.
Published: April 2023

PDF file - 2863K, Impact of unevenly distributed resistance mechanisms between training and test sets on signature performance (S1); Impact of different distributions of resistance mechanisms in training and test sets on signature performance (S2); Impact of cohort sub-stratification on signature performance (S3).
Supplementary Materials and Methods from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: April 2023

PDF file - 116KB
Supplementary Methods, Figure Legends, Tables 1 - 5 from HNRNPAB Induces Epithelial–Mesenchymal Transition and Promotes Metastasis of Hepatocellular Carcinoma by Transcriptionally Activating SNAIL
Authors: Zhou Zheng-Jun , Dai Zhi , Zhou Shao-Lai , Hu Zhi-Qiang , Chen Qing , Zhao Yi-Ming , Shi Ying-Hong , Gao Qiang , Wu Wei-Zhong , Qiu Shuang-Jian , Zhou Jian , Fan Jia
Published: April 2023

PDF file - 209K, Supplementary Table S1. Clinicopathologic characteristics of HCC patients. Supplementary Table S2. Primer sequences used in this study. Supplementary Table S3. Primary antibodies used in western blot, immunohistochemistry and immunofluorescence tests. Supplementary Table S4. Correlation between hnRNPAB and Snail expression and clinicopathologic characteristics in HCC (n=323). Supplementary Table S5. Univariate and Multivariate analyses of prognostic factors with TTR and OS in HCC patients (n=323).
Supplementary Table 3 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: April 2023

XLSX file - 613K, Genes significantly downregulated in samples with either CUL3 or NRF2 mutations
Supplementary Figure Legend from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: April 2023

PDF file - 88K
Supplementary Methods from Activation of HIF2α in Kidney Proximal Tubule Cells Causes Abnormal Glycogen Deposition but not Tumorigenesis
Authors: Fu Leiping , Wang Gang , Shevchuk Maria M. , Nanus David M. , Gudas Lorraine J.
Published: April 2023

PDF file - 75K, GGT-HIF2αM3 transcript quantification
Supplementary Figure Legend from HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients
Authors: Munir Shamaila , Andersen Gitte Holmen , Met Özcan , Donia Marco , Frøsig Thomas Mørch , Larsen Stine Kiaer , Klausen Tobias Wirenfeldt , Svane Inge Marie , Andersen Mads Hald
Published: April 2023

PDF file - 88K
Supplementary Figure 4 from Low PIP4K2B Expression in Human Breast Tumors Correlates with Reduced Patient Survival: A Role for PIP4K2B in the Regulation of E-Cadherin Expression
Authors: Keune Willem-Jan , Sims Andrew H. , Jones David R. , Bultsma Yvette , Lynch James T. , Jirström Karin , Landberg Goran , Divecha Nullin
Published: April 2023

PDF file - 60K, A. The gene expression profiles of PIP4K2B in normal and tumour tissues were extracted (GSE10780) and compared. PIP4K2B levels were significantly lower in tumor samples (P=0.04) B. Breast tumour samples from 17 data sets representing 2999 tumours were clustered into the molecular subtypes shown. The PIP4K2B expressions are shown as box plots. Significant differences were determined between different subtyps and the p values for the comparisons are shown in the inset.
Supplementary Methods from Chromosome Instability Modulated by BMI1–AURKA Signaling Drives Progression in Head and Neck Cancer
Authors: Chou Chun-Hung , Yang Neng-Kai , Liu Ting-Yun , Tai Shyh-Kuan , Hsu Dennis Shin-Shian , Chen Ya-Wei , Chen Yann-Jang , Chang Cheng-Chi , Tzeng Cheng-Hwai , Yang Muh-Hwa
Published: April 2023

PDF file - 94KB, Includes quantitative PCR, western blot and immunoprecipitation, wound healing assay, transwell invasion assay, HNSCC sample collection, statistical analysis and one supplementary reference
Supplementary Figure Legends from Chromosome Instability Modulated by BMI1–AURKA Signaling Drives Progression in Head and Neck Cancer
Authors: Chou Chun-Hung , Yang Neng-Kai , Liu Ting-Yun , Tai Shyh-Kuan , Hsu Dennis Shin-Shian , Chen Ya-Wei , Chen Yann-Jang , Chang Cheng-Chi , Tzeng Cheng-Hwai , Yang Muh-Hwa
Published: April 2023

PDF file - 104KB
Supplementary Figures S1-S5 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Authors: Santo Evan E. , Stroeken Peter , Sluis Peter V. , Koster Jan , Versteeg Rogier , Westerhout Ellen M.
Published: April 2023

Supplementary Figures S1-S5 PDF file - 807K, Baseline FACS data to Figure 3b (S1); Total FOXO3a and phosphorylated FOXO3a levels correlate with apoptosis across a cell line panel following MK-2206 treatment (S2); Genes regulated by PI3K/AKT signaling and FOXO3a are highly prognostic in the NB88 (S3); Gene regulatory activity of FOXO3a (S4); Kaplan-Meier survival curves for individual FOXO target genes in the NB88 dataset (S5)
Supplementary Figure 6 from Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
Authors: Spassov Danislav S. , Wong Ching Hang , Wong Sunny Y. , Reiter Jeremy F. , Moasser Mark M.
Published: April 2023

PDF file - 428K, Wound healing in Trask+/+ and Trask-/- mice
Supplementary Figure 3 from Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
Authors: Spassov Danislav S. , Wong Ching Hang , Wong Sunny Y. , Reiter Jeremy F. , Moasser Mark M.
Published: April 2023

PDF file - 485K, Neoplasia in SmoM2-induced mice epidermis
Supplementary Methods from Monoclonal Antibody Targeting of the Cell Surface Molecule TM4SF5 Inhibits the Growth of Hepatocellular Carcinoma
Authors: Kwon Sanghoon , Choi Kyung-Chan , Kim Young-Eun , Ha Yang-Wha , Kim Dongbum , Park Byoung Kwon , Wu Guang , Kim Doo-Sik , Lee Younghee , Kwon Hyung-Joo
Published: April 2023

PDF file - 158KB
Supplementary Figure 4 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: April 2023

PDF file - 1318K, Fig S4. DTNB or AS101 sensitize high VLA-4 expressing lekemic cells from AML patients, to chemotherapy.
Supplementary Figure 1 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: April 2023

PDF file - 1027K, Fig. S1: AS101 induces chemotherapy-induced apoptotic death by decreasing VLA-4 activity.
Supplementary Figure 3 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: April 2023

PDF file - 457K, Circadian gene expression patterns in liver and colon mucosa according to chronotoxicity Class.
Supplementary Table 2 from Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer
Authors: Zhou Zhuan , Liu Fangfang , Zhang Zhi-Song , Shu Feifei , Zheng Yangyang , Fu Li , Li Lu-Yuan
Published: April 2023

PDF file - 63KB, Amino acid sequences of peptides resembling potential phosphorylation sites on the RHBDF1 protein.
Supplementary Figures 1 - 6 from Human Rhomboid Family-1 Suppresses Oxygen-Independent Degradation of Hypoxia-Inducible Factor-1α in Breast Cancer
Authors: Zhou Zhuan , Liu Fangfang , Zhang Zhi-Song , Shu Feifei , Zheng Yangyang , Fu Li , Li Lu-Yuan
Published: April 2023

PDF file - 440KB, Immunohistochemical analyses of RHBDF1 and HIF1a expression in breast cancer clinical specimens (S1). RHBDF1 action on HIF1a stability does not involve HIF1a mRNA levels (S2). Prediction of transmembrane topology and phosphorylation sites of RHBDF1 (S3). Effects of peptide VR56 on the expression of HIF1a targeted genes and breast cancer cell viability (S4). Inhibitory effect of RHBDF1 gene silencing in MCF7 cells on HIF1a stability (S5). Western blotting analysis showing involvement of RACK1 and RHBDF1 in HIF1a stabilization in breast cancer cell MCF7 or T47D (S6).
Supplementary Figure Legend from Inhibition of Protein Kinase CK2 Reduces Cyp24a1 Expression and Enhances 1,25-Dihydroxyvitamin D3 Antitumor Activity in Human Prostate Cancer Cells
Authors: Luo Wei , Yu Wei-Dong , Ma Yingyu , Chernov Mikhail , Trump Donald L. , Johnson Candace S.
Published: April 2023

PDF file - 69K
Supplementary Figure 2 from Inhibition of Protein Kinase CK2 Reduces Cyp24a1 Expression and Enhances 1,25-Dihydroxyvitamin D3 Antitumor Activity in Human Prostate Cancer Cells
Authors: Luo Wei , Yu Wei-Dong , Ma Yingyu , Chernov Mikhail , Trump Donald L. , Johnson Candace S.
Published: April 2023

PDF file - 2492K, Effect of 25D3 in combination with TBBz on CYP24A1 mRNA expression and cell proliferation in PC3 cell.
Supplementary Table 1 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: April 2023

PDF file - 382K, Peptide description. ID and sequence in single letter amino acid code of each peptide is shown
Supplementary Figures 1 - 6 from Phenotypic Profiling of DPYD Variations Relevant to 5-Fluorouracil Sensitivity Using Real-time Cellular Analysis and In Vitro Measurement of Enzyme Activity
Authors: Offer Steven M. , Wegner Natalie J. , Fossum Croix , Wang Kangsheng , Diasio Robert B.
Published: April 2023

PDF file - 497K, Supplementary Figures: 1. Determining the range of linear response for DPD expression and enzyme activity. 2. Analysis of CI profiles using a single analysis time. 3. Establishment of measurement times independently for each culture. 4. Comparison of slope at the toxicity time point. 5. Comparison of slope at the recovery time point. 6. Location of amino acids 534 and 543 within the 5-FU binding pocket of DPD.
Supplementary Figure 6 from Regulation of CD4+NKG2D+ Th1 Cells in Patients with Metastatic Melanoma Treated with Sorafenib: Role of IL-15Rα and NKG2D Triggering
Authors: Romero Ana I. , Chaput Nathalie , Poirier-Colame Vichnou , Rusakiewicz Sylvie , Jacquelot Nicolas , Chaba Kariman , Mortier Erwan , Jacques Yannick , Caillat-Zucman Sophie , Flament Caroline , Caignard Anne , Messaoudene Meriem , Aupérin Anne , Vielh Philippe , Dessen Philippe , Porta Camillo , Mateus Christine , Ayyoub Maha , Valmori Danila , Eggermont Alexander , Robert Caroline , Zitvogel Laurence
Published: April 2023

PDF file - 94K, 2D Clustering of LogRatios (D21/D0) of gene expression post- (D21) and pre-therapy (D0) with sorafenib/temozolomide.