bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Dietary Supplementation with a Ferulic Acid-Rich Bioactive Component of Wheat Bran in a Murine Model of Graft-Versus-Host Disease
Authors: Preciado Silvia , Martínez-Villaluenga Cristina , Rico Daniel , Muntión Sandra , García-Macías María-Carmen , Navarro-Bailón Almudena , Martín-Diana Ana Belén , Sánchez-Guijo Fermín
Published: October 2023

Graft-versus-host disease (GvHD) is a common and severe complication following allogeneic hematopoietic stem cell transplantation (HSCT). Its prevention and treatment is a major challenge. Ferulic acid (FA) has anti-inflammatory and antioxidant properties that could be attractive in this setting. Our aim was to evaluate a bioactive ingredient derived from wheat bran (WB), selected for its high concentration of FA, in a murine model of GvHD. The ingredient was obtained via a bioprocess involving hydrolysis and spray-drying. GvHD was induced via HSCT between MHC-mismatched mouse strains. FA treatment was administered orally. Survival and disease scores (weight loss, hunching, activity, fur texture, and skin integrity, each scored between 0 and 2 depending on disease severity) were recorded daily, histological evaluation was performed at the end of the experiment, and serum inflammatory cytokines were analyzed on days 9 and 28. Treatment with FA did not protect GvHD mice from death, nor did it diminish GvHD scores. However, histological analysis showed that ulcers with large areas of inflammatory cells, vessels, and keratin were less common in skin samples from FA-treated mice. Areas of intense inflammatory response were also seen in fewer small intestine samples from treated mice. In addition, a slight decrease in INF-γ and TNF-α expression was observed in the serum of treated mice on day 28. The results showed some local effect of the ingredient intervention, but that the dose used may not be sufficient to control or reduce the inflammatory response at the systemic level in mice with GvHD. Higher dosages of FA may have an impact when evaluating the immunomodulatory capabilities of the hydrolyzed WB ingredient. Thus, further experiments and the use of technological strategies that enrich the ingredients in soluble ferulic acid to improve its efficacy in this setting are warranted.
Associations of Combined Lifestyle Factors with MAFLD and the Specific Subtypes in Middle-Aged and Elderly Adults: The Dongfeng-Tongji Cohort Study
Authors: Li Hongxia , Cao Zhiqiang , Li Jingxi , King Lei , Zhang Zhuangyu , Zhao Ying , Zhang Siyi , Song Yajing , Zhang Qian , Chen Liangkai , Tang Yuhan , Dai Lingling , Yao Ping
Published: October 2023

Metabolic dysfunction-associated fatty liver disease (MAFLD) is the crucial pathogenesis for intra-hepatic and extra-hepatic diseases, especially in elderly adults. Lifestyle management may be a modifiable cost-effective measure for MAFLD prevention, but the evidence is limited. A total of 23,408 middle-aged and elderly individuals were included in a longitudinal study from 2008 to 2018. Combined lifestyle scores (range 0–6) were evaluated by BMI, smoking, drinking, diet, physical activity, and sleep. Logistic regression models were used to calculate ORs for the risks of MAFLD and specific subtypes. The mean age of participants was 61.7 years, and 44.5% were men. Compared with poor lifestyle (scores 0–2), ORs (95% CIs) of the ideal lifestyle (scores 5–6) were 0.62 (0.57–0.68) for MAFLD, 0.31 (0.28–0.34) for MAFLD with excess weight and obesity, 0.97 (0.75–1.26) for MAFLD with diabetes, and 0.56 (0.51–0.62) for MAFLD with metabolic dysregulation. Additionally, lifestyle improvement was associated with lower risks of MAFLD (OR, 0.76; 95% CI, 0.68–0.86), MAFLD with excess weight and obesity (OR, 0.72; 95% CI, 0.63–0.81), MAFLD with diabetes (OR, 0.74; 95% CI, 0.54–1.02) and MAFLD with metabolic dysregulation (OR, 0.49; 95% CI, 0.43–0.55), respectively. Our findings suggest that adherence to a combined healthy lifestyle was associated with lower risks of MAFLD, particularly in excess weight/obese individuals or those with metabolic dysregulation.
A Link between Prenatal Stage of Life during the Great Chinese Famine and Subsequent Depressive Symptoms among Middle-Aged and Older Adults
Authors: Du Yushan , Luo Yanan , Nie Lirong , Ren Ziyang , Sun Jinfang , Liu Jufen
Published: October 2023

Prenatal malnutrition may increase the risk of depressive symptoms in adulthood. This study investigated the association between prenatal exposure to malnutrition with risk of depressive symptoms in middle-aged and older adults using the Chinese Great Famine of 1959–1961 as a natural experiment. Data were obtained from the China Health and Retirement Longitudinal Study baseline survey (2011). A total of 5391 individuals born from 1956 to 1965 were included in the study. Depressive symptoms were ascertained via the Center for Epidemiological Studies Depression Scale short form. Famine severity was measured using the cohort size shrinkage index. Difference-in-differences models were used to explore the association between prenatal famine exposure and later-life depressive symptoms. Compared with the post-famine cohort (1963–1965), famine cohorts (1959–1962) were 4.74 times (95% CI = 1.28–8.20) as likely to develop depressive symptoms. The stratified analysis found that prenatal exposure to famine was associated with depressive symptoms in rural residents but not those living in urban areas. In rural females, prenatal malnutrition was associated with a higher risk of depressive symptoms. However, there was no significant association between prenatal malnutrition and depressive symptoms in rural males. Our results indicated that prenatal malnutrition may contribute to a higher risk for depressive symptoms in later life among female rural residents.
The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism
Authors: Tencerova Michaela , Duque Gustavo , Beekman Kerensa M. , Corsi Alessandro , Geurts Jeroen , Bisschop Peter H. , Paccou Julien
Published: October 2023

This review focuses on providing physicians with insights into the complex relationship between bone marrow adipose tissue (BMAT) and bone health, in the context of weight loss through caloric restriction or metabolic and bariatric surgery (MBS), in people living with obesity (PwO). We summarize the complex relationship between BMAT and bone health, provide an overview of noninvasive imaging techniques to quantify human BMAT, and discuss clinical studies measuring BMAT in PwO before and after weight loss. The relationship between BMAT and bone is subject to variations based on factors such as age, sex, menopausal status, skeletal sites, nutritional status, and metabolic conditions. The Bone Marrow Adiposity Society (BMAS) recommends standardizing imaging protocols to increase comparability across studies and sites, they have identified both water–fat imaging (WFI) and spectroscopy (1H-MRS) as accepted standards for in vivo quantification of BMAT. Clinical studies measuring BMAT in PwO are limited and have shown contradictory results. However, BMAT tends to be higher in patients with the highest visceral adiposity, and inverse associations between BMAT and bone mineral density (BMD) have been consistently found in PwO. Furthermore, BMAT levels tend to decrease after caloric restriction-induced weight loss. Although weight loss was associated with overall fat loss, a reduction in BMAT did not always follow the changes in fat volume in other tissues. The effects of MBS on BMAT are not consistent among the studies, which is at least partly related to the differences in the study population, skeletal site, and duration of the follow-up. Overall, gastric bypass appears to decrease BMAT, particularly in patients with diabetes and postmenopausal women, whereas sleeve gastrectomy appears to increase BMAT. More research is necessary to evaluate changes in BMAT and its connection to bone metabolism, either in PwO or in cases of weight loss through caloric restriction or MBS, to better understand the role of BMAT in this context and determine the local or systemic factors involved.
Effects of Lactobacillus plantarum and Weissella viridescens on the Gut Microbiota and Serum Metabolites of Mice with Antibiotic-Associated Diarrhea
Authors: Yan Zhiwei , Liu Zhuangzhuang , Ma Yong , Yang Zhao , Liu Gang , Fang Jun
Published: October 2023

Antibiotic-associated diarrhea (AAD) refers to diarrhea caused by gut microbiota disorders after the use of antibiotics, which seriously threatens the health of humans and animals. Therefore, it is necessary to find an effective therapy to treat AAD. This research aimed to explore the effects of Lactobacillus plantarum H-6 (L. plantarum H-6) and Weissella viridescens J-1 (W. viridescens J-1) on alleviating antibiotic-associated diarrhea induced by lincomycin hydrochloride (LH) in mice. The results show that L. plantarum H-6 could significantly reduce the expression of pro-inflammatory factors such as IL-1β and IL-6 in colon tissue. At the same time, L. plantarum H-6 significantly increased the abundance of Lactobacillus and Akkermansia, decreased the abundance of Bacteroides, and increased the contents of L-tryptophan, LysoPC (20:4 (8Z, 11Z, 14Z, 17Z)), reduced riboflavin, threoninyl–methionine, and N-palmitoyl in serum. However, W. viridescens J-1 had little effect on the treatment of AAD. It can be concluded that L. plantarum H-6 can regulate mice’s colonic microbial composition, improve their serum metabolic process, and alleviate antibiotic-associated diarrhea. This research may provide a novel therapeutic option for AAD.
Examining the Nutrition of Cardiological Patients in Hospitals: Evaluating the Discrepancy between Received Diets and Reference Diet Based on ESC 2021 Guidelines—Hospital Diet Medical Investigation) (HDMI) Study
Authors: Śliż Daniel , Jodczyk Alicja Monika , Łakoma Klaudia , Kucharska Alicja , Panczyk Mariusz , Rostkowska Olga Maria , Turlej Karolina , Młynarska Agnieszka , Drożdż Jarosław , Jarzębska-Wódka Milena , Wierzbiński Piotr , Grabowski Marcin , Ukleja Anna , Adamczyk Natalia , Baska Alicja , Wiecha Szczepan , Barylski Marcin , Poliwczak Adam Rafał , Mamcarz Artur
Published: October 2023

Cardiovascular diseases (CVDs) are the leading causes of death worldwide. CVDs have become the dominant cause of death and have been a significant health challenge since the second half of the 20th century in the Polish population. The aim of our HDMI (hospital diet medical investigation) study was to examine the quality of the hospital diets given to cardiac patients and assess how much they adhere to the European Society of Cardiology (ESC) 2021 guidelines. By comparing the diets received by patients with the recommended dietary patterns outlined in the ESC 2021 guidelines, we sought to identify discrepancies. The study was conducted in two steps: creating a 7-day model menu and comparing it with the received diets and then making comparisons with ESC 2021 guidelines. Additionally, we designed a survey to obtain the characteristics of the hospitals. The results show that the nutrition in hospitals remains substandard. None of the diets had an appropriate salt supply or predominance of plant-based food patterns. Only 1/7 diets avoided sweetened beverages, and 2/7 diets had an appropriate amount of fiber. This underscores a gap in the healthcare system to improve patients’ health by implementing dietary interventions that foster the development of healthy eating habits.
Neuroprotection with Bioactive Compounds
Authors: del Río Carmen , Segura-Carretero Antonio
Published: October 2023

Bioactive compounds are found in foods in small quantities and represent extra nutritional constituents known to exert beneficial effects on health beyond their nutritional value [...]
Pharmacogenomic Analysis of Combined Therapies against Glioblastoma Based on Cell Markers from Single-Cell Sequencing
Authors: Liu Junying , Wu Ruixin , Yuan Shouli , Kelleher Robbie , Chen Siying , Chen Rongfeng , Zhang Tao , Obaidi Ismael , Sheridan Helen
Published: October 2023

Glioblastoma is the most common and aggressive form of primary brain cancer and the lack of viable treatment options has created an urgency to develop novel treatments. Personalized or predictive medicine is still in its infancy stage at present. This research aimed to discover biomarkers to inform disease progression and to develop personalized prophylactic and therapeutic strategies by combining state-of-the-art technologies such as single-cell RNA sequencing, systems pharmacology, and a polypharmacological approach. As predicted in the pyroptosis-related gene (PRG) transcription factor (TF) microRNA (miRNA) regulatory network, TP53 was the hub gene in the pyroptosis process in glioblastoma (GBM). A LASSO Cox regression model of pyroptosis-related genes was built to accurately and conveniently predict the one-, two-, and three-year overall survival rates of GBM patients. The top-scoring five natural compounds were parthenolide, rutin, baeomycesic acid, luteolin, and kaempferol, which have NFKB inhibition, antioxidant, lipoxygenase inhibition, glucosidase inhibition, and estrogen receptor agonism properties, respectively. In contrast, the analysis of the cell-type-specific differential expression-related targets of natural compounds showed that the top five subtype cells targeted by natural compounds were endothelial cells, microglia/macrophages, oligodendrocytes, dendritic cells, and neutrophil cells. The current approach—using the pharmacogenomic analysis of combined therapies—serves as a model for novel personalized therapeutic strategies for GBM treatment.
Preliminary Assessment of Polysaccharide-Based Emulgels Containing Delta-Aminolevulinic Acid for Oral Lichen planus Treatment
Authors: Szymańska Emilia , Potaś Joanna , Maciejczyk Mateusz , Sulewska Magdalena Ewa , Pietruska Małgorzata , Zalewska Anna , Pietruska Aleksandra , Winnicka Katarzyna
Published: October 2023

Photodynamic therapy using delta-aminolevulinic acid is considered a promising option in the treatment of oral lichen planus. In the present work, three emulgel compositions prepared from natural polysaccharide gums, tragacanth, xanthan and gellan, were preliminarily tested for oromucosal delivery of delta-aminolevulinic acid. Apart from cytotoxicity studies in two gingival cell lines, the precise goal was to investigate whether the presence of the drug altered the rheological and mucoadhesive behavior of applied gelling agents and to examine how dilution with saliva fluid influenced the retention of the designed emulgels by oromucosal tissue. Ex vivo mucoadhesive studies revealed that a combination of xanthan and gellan gum enhanced carrier retention by buccal tissue even upon dilution with the saliva. In turn, the incorporation of delta-aminolevulinic acid favored interactions with mucosal tissue, particularly formulations comprised of tragacanth. The designed preparations had no significant impact on the cell viability after a 24 h incubation in the tested concentration range. Cytotoxicity studies demonstrated that tragacanth-based and gellan/xanthan-based emulgels might exert a protective effect on the metabolic activity of human gingival fibroblasts and keratinocytes. Overall, the presented data show the potential of designed emulgels as oromucosal platforms for delta-aminolevulinic acid delivery.
Association of Single-Nucleotide Polymorphisms in Capecitabine Bioactivation Pathway with Adjuvant Therapy Safety in Colorectal Cancer Patients
Authors: Cura Yasmin , Sánchez-Martín Almudena , Márquez-Pete Noelia , González-Flores Encarnación , Martínez-Martínez Fernando , Pérez-Ramírez Cristina , Jiménez-Morales Alberto
Published: October 2023

Capecitabine, an oral prodrug of 5-fluorouracil (5-FU), is part of the standard treatment of colorectal cancer (CRC). Severe adverse dose limiting reactions that impair treatment safety and lead to treatment suspension remain a relevant concern. Single-nucleotide polymorphisms (SNPs) in genes involved in the activation of capecitabine may alter the bioavailability of 5-FU and thereby affect therapy outcomes. The aim of this study was to evaluate the association of these SNPs with severe toxicity and treatment suspension in patients with CRC treated with capecitabine-based therapy. An ambispective cohort study was conducted, including 161 patients with CRC. SNPs were analyzed using real-time PCR with TaqMan® probes. Toxicity was assessed according to the National Cancer Institute Common Terminology Criteria for Adverse Events v.5.0. CES1 rs71647871-A was associated with a severe hand–foot syndrome (p = 0.030; OR = 11.92; 95% CI = 1.46–73.47; GG vs. A). CDA rs1048977-CC (p = 0.030; OR = 2.30; 95% CI 1.09–5.00; T vs. CC) and capecitabine monotherapy (p = 0.003; OR = 3.13; 95% CI 1.49–6.81) were associated with treatment suspension due to toxicity. SNPs CES1 rs71647871 and CDA rs1048977 may act as potential predictive biomarkers of safety in patients with CRC under capecitabine-based adjuvant therapy.
The Other Side of Plastics: Bioplastic-Based Nanoparticles for Drug Delivery Systems in the Brain
Authors: Lamparelli Erwin Pavel , Marino Marianna , Szychlinska Marta Anna , Della Rocca Natalia , Ciardulli Maria Camilla , Scala Pasqualina , D'Auria Raffaella , Testa Antonino , Viggiano Andrea , Cappello Francesco , Meccariello Rosaria , Della Porta Giovanna , Santoro Antonietta
Published: October 2023

Plastics have changed human lives, finding a broad range of applications from packaging to medical devices. However, plastics can degrade into microscopic forms known as micro- and nanoplastics, which have raised concerns about their accumulation in the environment but mainly about the potential risk to human health. Recently, biodegradable plastic materials have been introduced on the market. These polymers are biodegradable but also bioresorbable and, indeed, are fundamental tools for drug formulations, thanks to their transient ability to pass through biological barriers and concentrate in specific tissues. However, this “other side” of bioplastics raises concerns about their toxic potential, in the form of micro- and nanoparticles, due to easier and faster tissue accumulation, with unknown long-term biological effects. This review aims to provide an update on bioplastic-based particles by analyzing the advantages and drawbacks of their potential use as components of innovative formulations for brain diseases. However, a critical analysis of the literature indicates the need for further studies to assess the safety of bioplastic micro- and nanoparticles despite they appear as promising tools for several nanomedicine applications.
Characterization of Graft Copolymers Synthesized from p-Aminosalicylate Functionalized Monomeric Choline Ionic Liquid
Authors: Mazur Aleksy , Neugebauer Dorota
Published: October 2023

An ionic liquid based on the monomeric choline, specifically [2-(methacryloyloxy)ethyl]-trimethylammonium chloride (TMAMA), underwent biofunctionalization through an ion exchange reaction with the model drug anion: p-aminosalicylate (PAS), a primary antibiotic for tuberculosis treatment. This modified biocompatible IL monomer (TMAMA/PAS) was subsequently copolymerized with methyl methacrylate (MMA) to directly synthesize the well-defined graft conjugates with regulated content of ionic fraction with PAS anions (up to 49%), acting as drug delivery systems. The length of the polymeric side chains was assessed by the monomer conversions, yielding a degree of polymerization ranging from 12 to 89. The density of side chains was controlled by “grafting from” using the multifunctional macroinitiators. In vitro drug release, triggered by the ion exchange between the pharmaceutical and phosphate anions in a PBS medium, occurred in the range of 71–100% (2.8–9.8 μg/mL). Owing to significant drug content and consistent release profiles, these particular graft copolymers, derived from biomodified IL monomers with ionically attached pharmaceutical PAS in the side chains, are recognized as potentially effective drug delivery vehicles.
An Improved Principal Component Analysis Method for the Interpolation of Missing Data in GNSS-Derived PWV Time Series
Authors: Zhu Dantong , Zhong Zhenhao , Zhang Minghao , Wu Suqin , Zhang Kefei , Li Zhen , Hu Qingfeng , Liu Xianlin , Liu Junguo
Published: October 2023

Missing data in precipitable water vapor derived from global navigation satellite systems (GNSS-PWV) is commonly a large hurdle in climatical applications, since continuous PWV is an important prerequisite. Interpolation using principal component analysis (PCA) is typically used to resolve this problem. However, the popular PCA-based interpolating methods, e.g., rank-deficient least squares PCA (RDPCA) and data interpolating empirical orthogonal function (DINEOF), often lead to unsatisfactory results. This study analyzes the relationship between missing data and PCA-based interpolation results and proposes an improved interpolation-based RDPCA (IRDPCA) that can take into account the PWV derived from ERA5 (ERA-PWV) as an additional aid. Three key steps are involved in the IRDPCA: initially interpolating missing data, estimating principal components through a functional model and optimizing the interpolation through an iterative process. Using a 6-year GNSS-PWV over 26 stations and ERA-PWV in Yunnan, China, the performance of the IRDPCA is compared with the RDPCA and DINEOF using simulation experiments based on both homogeneous data (i.e., interpolating ERA-PWV using available ERA-PWV) and heterogeneous data (i.e., interpolating GNSS-PWV using ERA-PWV). In the case of using homogeneous data, the root mean square (RMS) values of the interpolation errors are 3.45, 1.18 and 1.17 mm for the RDPCA, DINEOF and IRDPCA, respectively; while the values are 3.50, 2.50 and 1.55 mm in the heterogeneous case. These results demonstrate the superior performance of the IRDPCA in both the heterogeneous and homogeneous cases. Moreover, these methods are also applied to the interpolation of the real GNSS-PWV. The RMS, absolute bias and correlation of the GNSS-PWV are calculated by comparison with ERA-PWV. The results reveal that the interpolated GNSS-PWV using the IRDPCA is not impacted by the systematic discrepancies in the ERA-PWV and agrees well with the original data.
Multi-Label Radar Compound Jamming Signal Recognition Using Complex-Valued CNN with Jamming Class Representation Fusion
Authors: Meng Yunyun , Yu Lei , Wei Yinsheng
Published: October 2023

In the complex battlefield electromagnetic environment, multiple jamming signals can enter the radar receiver simultaneously due to the development of jammers and modulation technology. The received compound jamming signals aggravate the difficulty of recognition and subsequent counter-countermeasure. In the face of strong overlapping signals and unseen jamming signal combinations, the performance of existing recognition methods usually seriously degrades. In this paper, an end-to-end multi-label classification framework combining a complex-valued convolutional neural network (CV-CNN) and jamming class representations is proposed to automatically recognize the jamming signal components of compound jamming signals. A basic multi-label CV-CNN (ML-CV-CNN) is first designed to directly process time–domain complex signals and fully retain jamming signal information. Then, the jamming class representations are generated using prototype clustering implemented by learning vector quantization, and they are fused with the ML-CV-CNN using class decoupling implemented by the attention mechanism to construct a multi-label class representation CV-CNN (ML-CR-CV-CNN), which can better learn the class-related features required for recognition. Finally, an adaptive threshold calibration is adopted to obtain optimal recognition results by multi-threshold discrimination. Simulation results verify that the proposed method has superior recognition performance, which is reflected in the strong robustness to the varying jamming-to-noise ratio (JNR) and power ratio, faster convergence speed with high JNRs, and better generalization for unseen jamming signal combinations.
Spatiotemporal Analysis of Urban Blue Space in Beijing and the Identification of Multifactor Driving Mechanisms Using Remote Sensing
Authors: Chen Ya , Zhen Weina , Li Yu , Zhang Ninghui , Shi Yishao , Shi Donghui
Published: October 2023

With rapid urban development in Beijing, there is a critical need to explore urban natural resources and understand their underlying mechanisms. Urban blue space (UBS) has gained increasing attention due to its potential to drive microcirculation, mitigate heat islands, and enhance residents’ well-being. In this study, we used remote sensing data to extract UBS in Beijing and employed exploratory spatial data analysis (ESDA) methods to examine its spatial and temporal development over the past two decades. We adopted a mesoscopic perspective to uncover the full spectrum of landscape patterns and quantitatively simulate the mechanisms influencing the area of UBS and landscape patterns. Our findings are as follows: (1) The UBS area in Beijing exhibited fluctuating growth from 2000 to 2020. (2) Spatial clustering of UBS was stable with subtle changes. (3) The ecological conditions in Beijing improved over the last 21 years, indicated by increased habitat diversity and richness, while notable landscape fragmentation posed significant challenges. (4) Science and technology management-related factors, such as UEM, EDUI, and STI, emerged as the most influential mechanisms for the UBS area. The coefficients for these factors were 0.798, 0.759, and 0.758, respectively. Following closely were vegetation conditions (NDVI) with a coefficient of 0.697 and an annual average temperature (T) with a coefficient of 0.692. (5) Precipitation was identified as the most vital influencing factor for the UBS landscape, with a significant correlation coefficient of 0.732. It was followed by residential population (POP), with a coefficient of 0.692, and economic conditions represented by gross domestic product (GDP), with a coefficient of 0.691.
Combining Satellite Optical and Radar Image Data for Streamflow Estimation Using a Machine Learning Method
Authors: Wang Xingcan , Sun Wenchao , Lu Fan , Zuo Rui
Published: October 2023

River water surface extent can be extracted from optical and radar satellite images; this is useful for estimating streamflow from space. The radiation characteristics of open water from the visible and microwave bands are different and provide independent information. In this study, for the purpose of improving streamflow estimation from space for data-sparse regions, a method that combines satellite optical and radar images data for streamflow estimation using a machine learning technique was proposed. The method was demonstratedthrough a case study in the river segment upstream of the Ganzi gauging station on the Yalong River, China. Utilizing the support vector regression (SVR) model, the feasibility of different combinations of water surface area derived from Sentinel-1 synthetic aperture radar images (AREA_SAR), modified normalized difference water index derived from Landsat 8 images (MNDWI), and reflectance ratios between NIR and SWIR channels derived from MODIS images (RNIR/RSWIR) for streamflow estimation were evaluated through three experiments. In Experiment I, three models using AREA_SAR (Model 1), MNDWI (Model 2), and a combination of AREA_SAR and MNDWI (Model 3) were built; the mean relative error (MRE) and mean absolute error (MAE) of streamflow estimates corresponding to the SVR model using both AREA_SAR and MNDWI (Model 3) were 0.19 and 31.6 m3/s for the testing dataset, respectively, and were lower than two models using AREA_SAR (Model 1) or MNDWI (Model 2) solely as inputs. In Experiment II, three models with AREA_SAR (Model 4), RNIR/RSWIR (Model 5), and a combination of AREA_SAR and RNIR/RSWIR (Model 6) as inputs were developed; the MRE and MAE for the model using AREA_SAR and RNIR/RSWIR (Model 6) were 0.25 and 56.5 m3/s, respectively, which outperformed the two models treating AREA_SAR (Model 4) or MNDWI (Model 5) as single types of inputs. In Experiment III, three models using AREA_SAR (Model 7), MNDWI, and RNIR/RSWIR (Model 8) and the combination of AREA_SAR, MNDWI and RNIR/RSWIR (Model 9) were built; combining all three types of satellite observations (Model 9) exhibited the highest accuracy, for which the MRE and MAE were 0.18 and 18.4 m3/s, respectively. The results of all three experiments demonstrated that integrating optical and microwave observations could improve the accuracy of streamflow estimates using a data-driven model; the proposed method has great potential for near-real-time estimations of flood magnitude or to reconstruct past variations in streamflow using historical satellite images in data-sparse regions.
Sustainable Tourism Development and Ramsar Sites in Serbia: Exploring Residents’ Attitudes and Water Quality Assessment in the Vlasina Protected Area
Authors: Milanović Pešić Ana , Jojić Glavonjić Tamara , Denda Stefan , Jakovljević Dejana
Published: October 2023

This study aims to present the potential for sustainable tourism development on Vlasina Lake, which is, along with its surroundings, declared as a Ramsar site, Natural Asset of Exceptional Importance, IBA, IPA, PBA and Emerald area. A survey conducted among the residents indicated that they expressed positive attitudes towards sustainable tourism development, even though a small percentage of them are employed in tourism. Considering the lake as the most valuable part of this area, this study emphasized water quality assessment as the necessary condition for sustainable tourism development. Water quality indices (SWQI, CWQI and WPI) were used for water quality assessment for the period 2013–2022. Based on SWQI, Vlasina Lake has a good to excellent water quality and, according to WPI, has clean water suitable for tourism and recreation. The CWQI for overall water quality ranged from marginal to good. It is the highest for recreation, but it is based on only one parameter (pH), which is the limitation of this methodology. Based on field research, survey, water quality assessment and previous studies, it is concluded that this area has favorable conditions for developing various types of tourism, which could contribute to the future development of this undeveloped and unpopulated area.
Estimation of the Impact of Climate Change on Spinach Cultivation Areas in Türkiye
Authors: Deveci Huzur
Published: October 2023

Climate change is one of the most important problems that needs to be dealt with in Türkiye and worldwide. One of the sectors that will be most affected by climate change is the agriculture sector. For this reason, it is very important to adapt to changing climatic conditions, take the necessary precautions, and ensure sustainability in the agricultural sector today. The land suitability for spinach (Spinacia oleracea L.) cultivation, a vegetable that is rich in nutrients, has never been investigated in Türkiye. Therefore, it is important to investigate the suitability of spinach cultivation areas in Türkiye in the case of possible climatic changes in future years. The most important original value of this research is that three separate climate change prediction models were used, as opposed to using only a single climate change prediction model, to determine the land suitability for spinach cultivation. The aim of this study is to determine the land suitability for spinach in line with possible climate change prediction models and scenarios in Türkiye and its evaluation by comparing it with the current model. To achieve this goal, HADGEM2_ES, CNRM_CM5, and MPI_ESM_LR climate models and RCP 4.5 and RCP8.5 scenarios were used, and land suitability was determined and evaluated with the help of Ecocrop integrated into DIVA-GIS for spinach in Türkiye currently and in the 2050s. The results found that there will be decreases in suitable, very suitable, and excellent areas for spinach cultivation and increases in not-suited, very marginal, and marginal areas. Considering the possible temperature and precipitation changes, it has been observed that the areas in which spinach can be grown in Türkiye in the 2050s will be negatively affected by climate change due to the increasing temperature and decreasing precipitation in general, and solutions are proposed in this study to ensure sustainability.
Enzyme Activity and Dissolved Organic Carbon Content in Soils Amended with Different Types of Biochar and Exogenous Organic Matter
Authors: Bednik Magdalena , Medyńska-Juraszek Agnieszka , Ćwieląg-Piasecka Irmina , Dudek Michał
Published: October 2023

Biochars are proposed as a strategy for long-term carbon sequestration. High resistance for decomposition, low decay rate and long estimated lifetime allow for stable forms of carbon to be retained in the environment. Nevertheless, the application of pyrolyzed feedstock, particularly along with exogenous organic matter, may affect carbon dynamics in soil through the introduction of labile compounds and the stimulation of extracellular enzymes. The aim of this research was to evaluate the influence of biochars and unprocessed organic amendments in two agricultural soils on the dissolved organic carbon (DOC) content and activity of three enzymes involved in carbon turnover. In the incubation experiment, the activity of dehydrogenase, β-glucosidase, and cellulase and the DOC content were measured on days 30, 60, 90, 180, and 360. The addition of biochars stimulated dehydrogenase and β-glucosidase, while cellulase was suppressed. Fresh biomass enhanced the activity of the enzymes through a priming effect. DOC content was the highest in treatments with high enzyme activity, suggesting that it acted as a source of energy for microbes. The findings suggest that the biochar properties and the presence of exogenous organic matter affect microbial response in soil, which might be crucial for carbon sequestration. However, long-term studies are recommended to fully understand the mechanisms that determine the response of soil biota to biochar.
Slow Collecting: Sustainability and the Need for a Paradigm Shift by Iberian Collectors
Authors: Duarte Adelaide , Pérez-Ibáñez Marta
Published: October 2023

Collectors are major actors in the global art market as they often spend large sums of money fostering the business. Concerning sustainable collecting practices—i.e., the balance between what is the best for people and for the environment—collectors’ actions seem contradictory. Firstly, ontologically, to collect is to accumulate artworks; secondly, art—the object of the collectors’ desire—and the global art world are not closely aligned with the climate crisis. The art ecosystem encourages trips to participate in art events worldwide, increasing the carbon footprint impact, and rarely uses recycled materials, causing waste. The economic model of the art market lacks sustainability, raising the question: how can we promote a sustainable collecting attitude? In this exploratory study, we will observe art market players, especially the Iberian Peninsula collectors’ actions, in terms of their contribution to reducing the environmental impact of purchases. Based on data, reports, interviews, and published sources, we will investigate collectors’ awareness of the subject and evaluate their adopted actions. As, to date, no analysis has been carried out on the trends of Iberian collecting in the field of climate sustainability, we have focused our study on finding data from the primary source par excellence: the collectors themselves. The aim is to fuel the need for a paradigm shift, concluding on a slow collecting attitude.
Effect of Nanosilica on the Strength and Durability of Cold-Bonded Fly Ash Aggregate Concrete
Authors: Peng Xiuzhong , Wang Qinghua , Wu Jing
Published: October 2023

Cold-bonded Fly Ash Aggregate (CFAA), as an alternative to natural coarse aggregates, can prepare more lightweight, economical, and sustainable concrete. However, CFAA concrete has insufficient durability, which hinders its application in a salt-corrosion environment. Nanosilica (NS) has an advantage of high activity and is generally used as an efficient mineral admixture in engineering. This study aims to improve the strength and durability of CFAA concrete by incorporating NS. To this end, compression tests, splitting tensile tests, and microscopic analyses were performed to investigate the mechanical properties of the concrete containing different NS dosages. Subsequently, the dry–wet and freeze–thaw durability tests were conducted to evaluate the salt-corrosion resistance and the frost resistance in the water, Na2SO4 solution, and Na2CO3 solution. The results show the compressive and splitting tensile strength peak at 2 wt% NS dosage. In this instance, the concrete has an optimum microstructure and exhibits desirable salt-corrosion resistance in the late stage of dry–wet cycles. During freeze–thaw cycles, NS could improve the frost resistance of the concrete but scarcely diminished internal damage under sulfate attack. The study explores the long-term performance of NS-modified CFAA concrete, providing a simple and effective method to mitigate the concrete deterioration in a harsh environment.
Tourism and Environment: Ecology, Management, Economics, Climate, Health, and Politics
Authors: Buckley Ralf C. , Underdahl Sonya
Published: October 2023

We review research on tourism and the environment using a temporal framework, distinct from previous reviews. We identify six main phases, all still active, but with different histories. Initially, tourism was treated as a low-impact component of transport and urban accommodation, and the focus was on recreation, ecology and visitor management in parks. Interest then turned to environmental management and corporate social responsibility: wastes, resources, and ecolabels. The third phase analysed positive economic contributions to conservation by a small number of tourism enterprises, principally through private reserves and park funding. The fourth focussed on climate change and carbon offsets, and the fifth on mental health and human capital. The sixth and newest phase is political. Tourism developers, industry associations, and lobbyists have stepped up their longstanding efforts to gain control of parks and protected areas, in order to profit from preferential access to public resources. These efforts now include international instruments as well as policies, practices, and legislation in individual countries. Tourism has become a catspaw for a new form of land grab by private wealth portfolios for high-value nature property. We draw attention to tourism development land grabs in public protected areas as a key priority for urgent research.
Two-Way Slab Punching Shear Resistance: Experimental Insights into Basalt-FRP Bar as Flexural Reinforcement
Authors: Salihi Brwa , Hamad Feirusha
Published: October 2023

This study seeks to experimentally evaluate the punching shear performance of two-way concrete slabs reinforced with conventional steel and basalt fiber-reinforced polymer (basalt-FRP) bars subjected to punching loading condition. Basalt-FRP bars offer high tensile strength and corrosion resistance but are understudied in two-way concrete slabs concerning punching shear. This study aims to fill this gap, with key implications for future structural design considerations. To achieve the objectives of the study, six large-scale square slabs were fabricated and subjected to a concentric load until failure. The parameters of the experiment included are the type of reinforcement used (either basalt-FRP or steel), the percentage of basalt-FRP used (ranging from 0.88% to 1.77%), the size of the basalt-FRP bars used (either 16 or 12 mm), and the concrete’s compressive strength (25, 30, and 35 MPa). The findings from the tests showed that incorporating basalt-FRP bars with one-quarter equivalent axial stiffness (ρ(Ef/Es)) to that of steel significantly enhanced the punching shear resistance of flat slabs, achieving approximately 65% of the capacity observed in steel-reinforced control sample. Moreover, increasing the amount of basalt-FRP bar reinforcement to half of the equivalent axial stiffness of steel had a substantial effect in improving shear strength, reaching approximately 89% of the capacity observed in the steel-reinforced specimen and concurrently reducing deflection during the failure. Additionally, the reinforcement type and concrete compressive strength played a crucial role in determining the ultimate load, failure modes, and crack propagation patterns. The study reveals discrepancies between experimental results and existing models for punching shear in FRP-reinforced slabs. Certain prevalent models prove to be conservative in their estimates, while others offer more accurate predictions, indicating the need for comprehensive model refinement. The investigation found that one model, encompassing the majority of variables affecting punching shear, exhibited the highest level of precision, with a slight adjustment recommended to enhance its accuracy further. This study suggests a sustainable, more durable way to reinforce concrete in bridges and high-rise buildings, potentially improving construction efficiency, enhanced service life, and potential updates to building codes.
Physical-Mechanical Behavior of CDW and Tire Flake Integration in Building Block Manufacturing
Authors: Arreola-Sanchez Mauricio , Martinez-Molina Wilfrido , Chavez-Garcia Hugo Luis , Navarrete-Seras Marco Antonio , Borrego-Perez Jorge Alberto , Velazquez-Perez Judith Alejandara , Ruiz-Ruiz Rosalia , Cervantes-Servin Adrian Ixcoatl , Pelagio-Chávez Adriana , Alonso-Guzman Elia Mercedes
Published: October 2023

Among the construction products manufactured with Portland cement (PC) are (in addition to hydraulic concrete) construction blocks. These elements are used as masonry materials for the elaboration of walls in all types of construction. For the elaboration of these elements, large amounts of geomaterials such as sand are utilized. The aim of this investigation was to reduce the consumption of geomaterials using block manufacturing that incorporates construction and demolition waste as a substitute for gravel and tire flakes as a substitute for sand. These blocks were characterized by their resistance in a compression test, flexion, modulus of elasticity, electrical resistivity, moisture absorption, and MEB microscopy, as well as an analysis of the unit price for different mixtures. The results show that the addition of tire flakes severely decreased the blocks’ physical-mechanical performance and increased the production costs, while the incorporation of 50% construction and demolition waste achieved a performance very close to that of the control blocks and presented improvements in the modulus of elasticity, although the costs could be higher than those for the control blocks.
Analyzing Public Environmental Concerns at the Threshold to Reduce Urban Air Pollution
Authors: Yang Jialiang , Yin Wen , Jin Yi
Published: October 2023

This work focuses on the extraction and analysis of large-scale data from the Internet, specifically using panel data consisting of 273 prefecture-level cities spanning the period from 2011 to 2021. The data are processed using both the panel fixed-effect model and the panel smooth transformation model (PSTR). This study examines the relationship between public environmental concern and urban air pollution, as well as the impact of various city area divisions on public environmental concern and urban ambient air pollution. The regression analysis reveals several key findings: (1) It is observed that the impact of public participation in environmental pollution control on suppressing air pollution exhibits a lag of approximately three periods. This implies that it takes some time for the power of public participation to manifest its effect in reducing air pollution. (2) The study finds that urban public environmental concern, as measured by the Baidu Index, has a suppressive effect on air pollution once it surpasses a threshold value of 20,455.36. (3) This effect is found to be strengthened as the level of public concern increases. Lastly, it is noted that public environmental concern exhibits regional heterogeneity, which can be attributed to factors such as economic development and scientific and technological advancements. These factors influence the level of public environmental concern in different regions. The findings may be succinctly summarized as follows: geographical variations in public environmental concern can be attributed to the impact of economic growth and advancements in science and technology. Regional variability may arise from several sources, including economic growth, scientific and technical advancements, and other influences, all of which impact public environmental concerns.
Hybrid Fuzzy AHP and Frequency Ratio Methods for Assessing Flood Susceptibility in Bayech Basin, Southwestern Tunisia
Authors: Ali Zaineb , Dahri Noura , Vanclooster Marnik , Mehmandoostkotlar Ali , Labbaci Adnane , Ben Zaied Mongi , Ouessar Mohamed
Published: October 2023

Flash floods are a significant threat to arid and semi-arid regions, causing considerable loss of life and damage, including roads, bridges, check dams and dikes, reservoir filling, and mudslides in populated areas as well as agricultural fields. Flood risk is a complex process linked to numerous morphological, pedological, geological, anthropic, and climatic factors. In arid environments such as where Bayech basin is located in southwestern Tunisia, the hydrometric data are insufficient due to the absence of measuring points. Using the hybrid fuzzy Analytical Hierarchy Process (F-AHP) and the frequency ratio statistical methods, this study aims to map flooding risks in an ungauged basin that is extremely prone to flooding. Data related to soil texture, slope, land use, altitude, rainfall, drainage density, and distance from the river were used in the risk analysis. The obtained flood risk maps from both F-AHP and FR models were validated on the basis of the Receiver Operating Characteristic (ROC), the Area Under the Curve (AUC), and the inventory map. Results revealed that areas of high and very high susceptibility to flooding are mainly located in the downstream part of the basin, where the town of Gafsa is located. Other upstream sites are also at risk. In this basin, slope is predominantly behind runoff accumulation, whereas soil type plays a major role in amplifying waterproofing and therefore overflow. The results derived from both methods clearly demonstrate a viable and efficient assessment in flood-prone areas. The F-AHP and FR methods have ROC values of 95% and 97%, respectively. Considering these results in the decision-making process, these outputs would enable the implementation of the necessary measures to mitigate flood risk impacts ensure sustainable development along with an effective management in Tunisian arid environments, for the well-being of local communities at risk.