bluuebunny/crossref_metadata_2025 huggingface dataset:
PERAN OPINION LEADER DALAM SISTEM DAKWAH (Analisis Difusi Jaringan Komunikasi)
Authors: Hasanah Hasyim
Published: February 2019

This paper aims to explain the role of opinion leader in dakwah activities through the analysis of communication network diffusion. This paper uses a descriptive qualitative method, with a network analysis approach. The results showed that opinion leaders playan important role in accelerating and slowing the process of diffusion of dakwah information. The higher the ability of people to influence others, the higher the effort also in influencing behavior changes that  occur in  that  person.  This is because  the  opinion  leader has the characteristic of making himself a media through innovation into society as a social system. An opinion leader also becomes a reference for media behavior (media behavior). That is, when the opinion leader is a Dai, he is a information disseminator of dakwah information that makes himself as one of the media forming behavior to change the order of values, attitudes, and behavior of people in a systematic and structured. Double role of a Dai to achieve social system changes and realize the life of the people who Sallam, hasanah, and thayyibah, and getting of Ridho Allah SWT.

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Tulisan ini bertujuan untuk menjelaskan peran opinion leader dalam dakwah Islam melalui analisis difusi jaringan komunikasi. Tulisan ini menggunaakan metode kualitatif  deskriptif  dengan  pendekatan analisis jaringan. Hasil penelitian menunjukkan bahwa para pemimpin opini memegang peranan penting dalam mempercepat maupun memperlambat proses difusi informasi dakwah. Semakin tinggi kemampuan orang mempengaruhi orang lain, maka akan semakin tinggi pula usahanya dalam memengaruhi perubahan perilaku yang terjadi pada orang tersebut. Hal ini dikarenakan opinion leader memiliki karakteristik menjadikan dirinya sebagai media lewatnya  inovasi  ke dalam masyarakat sebagai  sebuah  sistem  sosial.  seorang opinion leader juga menjadi rujukan bagi perilaku media (media behavior). Artinya, ketika opinion leader adalah  seorang  dai,  maka  ia merupakan penyebar informasi  dakwah yang menjadikan dirinya sebagai salah satu media pembentuk perilaku untuk mengubah tatanan nilai, sikap, dan perilaku umat secara sistematis dan terstruktur.  Peran ganda seorang dai guna mencapai perubahan sistem sosial dan mewujudkan kehidupan umat yang salam, hasanah dan thayyibah serta memperoleh ridha Allah SWT.
STRATEGI DAKWAH AL BAYANUNI (Analisis Strategi Muhammad Abu Fatah Al Bayanuni Dalam Kitab Al Madkhal Ila Ilmi Dakwah)
Authors: Nizar Muklis
Published: February 2019

The strategy used in the da’wah must be in accordance with condition and activity-bused designed to realize the purpose da’wah. The complexity of the problems that develop tody. Da’wah always face different challenges according to the conditions of community life. Da’wah must be packed in such a way as to be accepted and understood by the community as mad’unya. Because it da’wah can not be done with perfunctory but must be with  careful planning and preparation understand the strategi steps to consider. The use of strategy or the right way is a benchmark of success from da’wah itself. But if the strategy used is not appropriate, will lead to the unexpected.

Depart from the above understanding shaykh Muhammad abu Fatah al Bayanuni contributed thoughts on the da’wah strategy contained in the book al madkhal ila ilmi da’wah. Strategy is a combination of planning, methods and tactics means/media to achieve the goal of da’wah.

Keywords : strategy, da’wah, muhammad abu fatah al bayanuni

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Strategi yang digunakan dalam dakwah harus sesuai dengan kondisi dan kegiatan yang dirancang untuk mewujudkan tujuan dakwah. Kompleksitas masalah yang berkembang goyah. Dakwah selalu menghadapi tantangan yang berbeda sesuai dengan kondisi kehidupan masyarakat. Dakwah harus dikemas sedemikian rupa agar diterima dan dipahami oleh masyarakat sebagai madunya. Karena itu dakwah tidak bisa dilakukan dengan asal saja tetapi harus dengan perencanaan dan persiapan yang matang memahami langkah-langkah strategis yang perlu dipertimbangkan. Penggunaan strategi atau cara yang benar adalah tolok ukur keberhasilan dari dakwah itu sendiri. Tetapi jika strategi yang digunakan tidak tepat, akan mengarah pada hal yang tidak terduga.

Berangkat dari pemahaman di atas shaykh Muhammad abu Fatah al Bayanuni mengkontribusikan pemikiran tentang strategi dakwah yang terkandung dalam buku al madkhal ila ilmi da'wah. Strategi adalah kombinasi dari perencanaan, metode dan taktik yang berarti / media untuk mencapai tujuan dakwah.

Kata kunci: strategi, dakwah, muhammad abu fatah al bayanuni
DAKWAH PADA MASYARAKAT MINANGKABAU (STUDI KASUS PADA KAUM PADRI)
Authors: Hati Putri Citra
Published: February 2019

Da’wah is a part that must exist in the life of religious people. One of the teachings of Islam, da’wah ia a duty that is charged to the adherents of religion. Padri movement oriented on renewal of society’s behavior and moral improvement of society in general and specially try to apply shariah which sourced from Al-Qur’an and as sunnah. And of course this Padri movement of da’wah thought that has philosophy value of da’wah which is closely related to improvement, renewal, and development. all these aspects is anticipative, creative, dynamic and relevant in its time. Islam in Minangkabau is known as egalitarian society. It is an open advice to anyone through local value (dimana bumi dipijak disitu langit dijunjung) and then expressed through a model of tolerance that is packaged in a cultural figure or more precisely the formula of social relationships naturally.

Keywords:  padri , method of da’wah, minangkabau.

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Dakwah adalah bagian yang pasti ada dalam kehidupan umat beragama. Salah satu ajaran Islam, dakwah merupakan kewajiban yang dibebankan agama kepada pemeluknya. Gerakan kaum Padri tersebut, berorientasi pada pembaruan tingkah laku masyarakat dan perbaikan moral masyarakat secara umum dan secara khusus berupaya menerapkan syari`ah yang bersumber dari al-Quran dan as-Sunnah. Dan tentu saja gerakan purifikasi kaum Padri mempunyai suatu langkah gerakan pemikiran dakwah yang memiliki nilai filosofi dakwah yang erat kaitannya dengan perbaikan (ishlah), pembaharuan (tajdid), dan pembangunan. Kesemua aspek tersebut merupakan metode pengembangan dakwah yang bersifat antisipatif, kreatif, dinamis dan relevan pada masanya.  Islam di Minangkabau dikenal sebagai masyarakat yang egaliter. Untuk konteks anjuran terbuka kepada siapapun melalui nilai lokal (dimana bumi dipijak disitu langit dijunjung) kemudian diekspresikan melalui model toleransi yang dikemas dalam sosok kultural atau lebih tepatnya formula hubungan –hubungan sosial secara natural.

 

Kata Kunci :  padri,  metode dakwah, minangkabau.
PROSES DAN MOTIF PERUBAHAN MODE BERJILBAB STANDAR KE SYAR’I PADA PELAJAR MA AL IRSYAD GAJAH DEMAK
Authors: Choliq Abdul
Published: February 2019

Abstract

               Headscarves are something that is familiar to Muslim women who function as someone's Muslim identity. The change in the standard veil mode to the shari'ah that occurs in Madrasah Aliyah students is a new thing out of the ordinary in the Madrasah. The change in the veil style is feared to trigger a negative response from the public who often perceive as a dangerous Islamic group. This study discusses the process of change using the hijab syar'i on students, the motive behind it and the changing attributes after using the hijab syar'i. The method used in this study is a qualitative method with a phenomenological approach. Data collection is done through interview and observation techniques. The results of this study indicate that the process of change towards the headscarf is done slowly by learning the source of books and the internet without studying the scholars 'who understand the problem of syara' about hijab. Furthermore, there are two motives behind the student's decision to switch to the hijab syar'I, which is first: the motive for (motive because) in the form of: religious motives, psychological motives and defense motives. Second, the goal motive (in-order-to-motive) is: the motive for receiving charity and the motive for improving worship. While aspects that change after students wear the hijab syar'I, namely: first, changes in physical attributes, changes in aspects of psychology and changes in idealism in worship.

 
PERPADUAN NILAI DAKWAH DAN ESTETIKA DALAM NOVEL KAMBING DAN HUJAN KARYA MAHFUD IKHWAN
Authors: Naufal Mazka Hauzan
Published: February 2019

The growth of islamic literature keeps a problem. For some critics, many works of fiction labeled "islamic literature" are problematic in terms of writing techniques and the value of aesthetic. Amidst the stream of criticism that highlighted the weaknesses of islamic literary products, emerged several literary works, which although not specifically labeled "islamic literature", contained symbols and islamic moral teachings that won prestigious literary awards. One of them is the novel Kambing dan Hujan by Mahfud Ikhwan. Using Robert Stanton's structural analysis approach, this article intends to describe how the values of da'wah and aesthetic values are combined in the novel Kambing and Hujan. Based on the analysis, two conclusions were drawn. First, the novel Kambing dan Hujan has structural density. Every intrinsic element is interrelated in harmony. Second, the novel Kambing and Hujan succeeded in combining aesthetic values (marked by structural density and harmony between elements) with the value of da'wah (which was marked by the existence of the content of Islamic teachings in it).

 
NETIZEN JURNALISME DAN TANTANGAN DAKWAH DI MEDIA BARU
Authors: Aziz Mokhamad Abdul
Published: February 2019

Perubahan media lama ke media baru diikuti dengan budaya baru masyarakat informasi. Mereka menyerbu internet dengan berbagai kompleksitasnya. Hal ini telah menguatkan budaya jurnalisme warga yang telah muncul beberapa tahun sebelumnya. Era kini bisa disebut sebagai era netizen journalism, yang harapannya dapat memberikan manfaat besar bagi masyarakat. Namun, saat ini tidak bisa dielakkan, dampak negatif internet begitu nyata, terbukti dengan banyaknya pelanggaran dan penyalahgunaannya. Ketidakpahaman atau keterbatasan pengetahuan netizen mengenai etika dan prinsip yang harus digunakan dalam bermedia sosial, maka dampak buruk terhadap penggunanya tidak bisa dihindari. Oleh sebab itu, diperlukan literasi media yang menyeluruh dan kontestual untuk menjelajah seluruh netizen agar memahami netiket di media baru. Kini netizen telah Social media bahkan harus dimanfaatkan sebagai sarana dakwah. Para ulama perilaku mencari format strategi yang jitu untuk berdakwah di media sosial.

 
Adapting to urban flooding: a case of two cities in South Asia
Authors: Pervin Ismat Ara , Rahman Sheikh Mohammad Mahbubur , Nepal Mani , Haque Abdul Kalam Enamul , Karim Humayun , Dhakal Ganesh
Published: February 2019

Cities in South Asia are experiencing storm water drainage problems due to a combination of urban sprawl, structural, hydrological, socioeconomic and climatic factors. The frequency of short duration, high-intensity rainfall is expected to increase in the future due to climate change. Given the limited capacity of drainage systems in South Asian cities, urban flooding and waterlogging is expected to intensify. The problem gets worse when low-lying areas are filled up for infrastructure development due to unplanned urban growth, reducing permeable areas. Additionally, solid waste, when dumped in canals and open spaces, blocks urban drainage systems and worsens urban flooding and waterlogging. Using hydraulic models for two South Asian cities, Sylhet (in Bangladesh) and Bharatpur (in Nepal), we find that 22.3% of the land area in Sylhet and 12.7% in Bharatpur is under flooding risk, under the current scenario. The flood risk area can be reduced to 3.6% in Sylhet and 5.5% in Bharatpur with structural interventions in the drainage system. However, the area under flood risk could increase to 18.5% in Sylhet and 7.6% in Bharatpur in five years if the cities' solid waste is not managed properly, suggesting that the structural solution alone, without proper solid waste management, is almost ineffective in reducing the long-term flooding risk in these cities.
O SENTIMENTO DE INVEJA SUSCITADO PELO CONSUMO DE PRODUTOS TURÍSTICOS DIVULGADO NO INSTAGRAM
Authors: De Souza Elnivan Moreira , Montenegro Rebeca Maria Bruno , Quezado Izabelle , Arruda Danielle Miranda de Oliveira
Published: February 2019

Este artigo verifica o papel do sentimento de inveja no consumo de viagens a partir do conteúdo visualizado no Instagram. Para tanto, foi realizada uma pesquisa quantitativa por meio de survey e os dados foram tratados com auxílio dos softwares SPSS, para análise descritiva e validação das escalas, e AMOS, para análise das relações regressoras entre as variáveis observáveis e os construtos. Constatou-se que os integrantes da amostra da pesquisa são potenciais consumidores de viagens, pois as realizam e acessam o Instagram com frequência, mas não são pessoas que tem o sentimento de inveja como determinante. Conclui-se afirmando que a mídia social Instagram não suscita o sentimento de inveja dos seus usuários no que se refere ao consumo de viagens. Como contribuição, ressalte-se a validação das escala de Inveja e Identificação Social que ainda não haviam sido validadas no Brasil. Para estudos futuros, propõe-se verificar a influência do sentimento por meio de outras mídias sociais como Facebook e Twitter, além de outros nichos de mercado relevantes. Metodologicamente, indica-se o uso de abordagens qualitativas, apoiada por técnica como análise do discurso, pois essa possibilitará uma análise minuciosa, capaz de detectar lacunas não cobertas pela abordagem quantitativa.
Uso de tecnologia no turismo cemiterial: Estudo sobre a visitação no Cemitério da Consolação, em São Paulo.
Authors: Bittencourt Dirceu Gonçalves , Moromizato Tatiane Kaori , Correa Cynthia
Published: February 2019

No âmbito do turismo cemiterial, a tecnologia mostra significativa relevância para auxiliar os visitantes a obterem informações detalhadas sobre as personalidades sepultadas e obras de arte dos túmulos. Todavia, o turismo cemiterial ainda é pouco difundido no Brasil, sendo o cemitério da Consolação pioneiro na promoção de visitas turísticas. Nesse sentido, o objetivo geral deste artigo é o de analisar a situação atual do turismo cemiterial na visitação ao Cemitério da Consolação em São Paulo. O estudo, de caráter qualitativo, foi desenvolvido com base em revisão bibliográfica e documental, visitas ao cemitério e condução de entrevistas com os responsáveis pela administração do serviço de visitação e tecnologia presente na necrópole selecionada. Como resultados, observa-se que é necessária uma pesquisa detalhada de demanda e perfil dos visitantes interessados no cemitério da Consolação como atividade de lazer/turismo, para que se possa implantar um projeto baseado em tecnologia de Realidade Aumentada (RA) incentivando a promoção de visitas autoguiadas.
The U-shaped Relationship Between Serum Methylene Tetrahydrofolate Reductase and Large-artery Atherosclerotic Stroke
Authors: He Yan , Zhu Zhengbao , Guo Daoxia , Zhang Huan , Zheng Xiaowei , Zeng Nimei , Zhang Qiu , Peng Hao , Zhong Chongke , Wang Aili , Xu Tan , Jin Jianhua , Zhang Yonghong , He Jiang
Published: February 2019

Background:

Methylene tetrahydrofolate reductase (MTHFR) gene polymorphisms
have been reported to be associated with ischemic stroke. However, the association between serum
MTHFR level and ischemic stroke has not yet been studied. We aimed to examine the association
between them in patients with large-artery atherosclerotic stroke and community-based healthy
controls.

Methods:

This study includes three hundred ninety-five patients with large-artery atherosclerotic
stroke from the China Antihypertensive Trial in Acute Ischemic Stroke (CATIS) and 395 age- and
sex-matched healthy controls from Chinese communities. Serum MTHFR concentrations were examined
and some conventional risk factors of stroke were collected. The association between serum
MTHFR and large-artery atherosclerotic stroke was evaluated.

Results:

A U-shaped association of serum MTHFR level with large-artery atherosclerotic stroke
was observed (p for nonlinearity =0.008). After multivariate adjustment, the odds ratios (95%
confidence intervals) of large-artery atherosclerotic stroke associated with the first, second, fourth,
and fifth quintiles of MTHFR were 5.62 (1.10-28.87), 2.13 (0.51-8.99), 1.08 (0.21-5.56), and 2.31
(0.57-9.34), respectively, compared with the third quintiles of MTHFR. Adding MTHFR quintiles
to a model containing conventional risk factors improved the predictive power for large-artery
atherosclerotic stroke (continuous net reclassification improvement=63.78%, p<0.001; categorical
net reclassification improvement=2.54%, p=0.012).

Conclusion:

There is a significant U-shaped relationship between serum MTHFR levels and largeartery
atherosclerotic stroke. Our findings raise the possibility that serum MTHFR may have a potential
role in the pathogenesis of large-artery atherosclerotic stroke.
Nanoparticle-assisted Therapeutic Strategies for Effective Cancer Management
Authors: Nandi Dinobandhu , Sharma Anshula , Prabhakar Pranav Kumar
Published: February 2019

Cancer is the second leading cause of death worldwide. There are various classes of medications
available for the management of cancer. Nanoparticles based drugs are the most preferred
category among them due to their specificity towards target and reduction in the dose of drugs.
Nanotechnology includes multiple subdisciplines like nanostructures, nanomaterials, and nanoparticles.
These nanostructure-based drugs have gained extrusion in the medical field because of their
small size, shape and high pharmacological efficacy. Nanomedicine is a booming field involving the
use of different types of nanoparticles to kill tumor and tumorous cells. Biodegradable nanometersized
particles have novel structural and physical properties that are attracting great interests from
pharmaceuticals for the targeted delivery of anticancer drugs and imaging contrast agents. These
nanoparticles are designed to increase more uptake of drugs or therapeutic genes into cancerous cells
while noncancerous cells are intact. In this review, different nanomaterials-based strategies for a
safe, fast, effective and targeted delivery system for drugs are discussed in relation to their anticancer
activities.
Study of Anti-inflammatory Activity of a New Non-opioid Analgesic on the Basis of a Selective Inhibitor of TRPA1 Ion Channels
Authors: Beskhmelnitsyna Evgeniya A. , Pokrovskii Mikhail V. , Kulikov Aleksandr L. , Peresypkina Anna A. , Varavin Evgeniy I.
Published: February 2019

Introduction:

Nowadays, the group of NSAIDs is used the most widely in order
to treat the inflammatory process. But its long-term administration increases the risk of
complications of pharmacotherapy. Therefore, today it is urgent to search for new molecules
that can selectively block biological targets that directly perceive inflammatory mediators.
One of such targets is TRPA1. ZC02-0012, a compound from the group of substituted
pyrazinopyrimidinones, which is a selective inhibitor of TRPA1 ion channel.

Objective:

The aim of our study was to study the anti-inflammatory activity of an innovative
molecule under the laboratory code ZC02-0012 from the group of selective inhibitors
of TRPA1 ion channel.

Materials and Methods:

Anti-inflammatory activity of ZC02-0012 was studied on the
model of acute exudative inflammation of the paw in response to subplantar injection in
the right hind paw of mice with 0.02 ml of 2% formaldehyde solution. The mass of the
paw was measured after 4 hours (peak edema) after phlogistic injection. The test substance
and the reference drug was administered intragastrically or intramuscularly 45 minutes before
the injection of formaldehyde solution. The presence and intensity of antiinflammatory
activity was judged by the inhibitory effect, represented in percent.

Results and Discussion:

Selective inhibitor of the TRPA1 ion channel ZC02-0012 revealed
the anti-inflammatory activity at doses of 3 and 9 mg/kg, its intensity is comparable to diclofenac
sodium.

Conclusion:

The selective inhibitor of the ion channel TRPA1, a substance under code
ZC02-0012, has an anti-inflammatory activity comparable with diclofenac sodium.
Acrylamide Induced Toxicity and the Propensity of Phytochemicals in Amelioration: A Review
Authors: Kunnel Shinomol George , Subramanya Sunitha , Satapathy Pankaj , Sahoo Ishtapran , Zameer Farhan
Published: February 2019

Acrylamide is widely found in baked and fried foods, produced in large amount in industries and is a prime component in toxicity. This review highlights various toxicities that are induced due to acrylamide, its proposed mode of action including oxidative stress cascades and ameliorative mechanisms using phytochemicals. Acrylamide formation, the mechanism of toxicity and the studies on the role of oxidative stress and mitochondrial dysfunctions are elaborated in this paper. The various types of toxicities caused by Acrylamide and the modulation studies using phytochemicals that are carried out on various type of toxicity like neurotoxicity, hepatotoxicity, cardiotoxicity, immune system, and skeletal system, as well as embryos have been explored. Lacunae of studies include the need to explore methods for reducing the formation of acrylamide in food while cooking and also better modulators for alleviating the toxicity and associated dysfunctions along with identifying its molecular mechanisms.
Antagonistic Property of G2013 (α-L-Guluronic Acid) on Gene Expression of MyD88, Tollip, and NF-κB in HEK293 TLR2 and HEK293 TLR4
Authors: Sharifi Laleh , Aghamohammadi Asghar , Aletaha Somaye , Bigdeli Razieh , Asgary Vahid , Bokaie Saied , Asgardoon Mohammad Hossein , Azizi Gholamreza , Mirshafiey Abbas
Published: February 2019

Introduction: Inhibition of Toll-like receptors (TLRs) signaling plays a crucial role in suppressing
the inflammation and available data presenting G2013 as an immunomodulatory agent, therefore,
we designed this study to answer whether G2013 can affect the signaling pathway of TLR2 and
TLR4.

Methods:

Cytotoxicity study of G2013 was performed by MTT assay. HEK293 TLR2 and HEK293
TLR4 cell lines were cultured and treated with low dose (5µg/ml) and high dose (25µg/ml) of G2013
for 24 hours. Gene expressions of MyD88, Tollip, and NF-κB were defined by quantitative real-time
PCR.

Results:

The cytotoxicity assay showed that the concentrations lesser than 125μg/ml of G3012 had no
apparent cytotoxicity, however, the concentrations of 5µg/ml and 25µg/ml could suppress the mRNA
expression of MyD88, Tollip and NF-κB in HEK293 TLR2 and HEK293 TLR4 cell lines.

Conclusion:

in our study, we verified the linkage between the immunosuppressive property of G2013
and TLR2, TLR4 signaling cascade; but so far, the specific target of G2013 and its molecular mechanism
has not been detected yet. We recommend further studies on other Patten Recognition Receptors
(PRRs)and other mechanisms of inflammation like oxidative stress to be conducted in the future.
Imatinib Uptake into Cells is Not Mediated by Organic Cation Transporters OCT1, OCT2, or OCT3, But is Influenced by Extracellular pH
Authors: Mettral Jaurès B. , Faller Nicolas , Cruchon Sandra , Sottas Loïc , Buclin Thierry , Schild Laurent , Choong Eva , Nahimana Aimable , Decosterd Laurent A.
Published: February 2019

Background:

Cancer cells undergo genetic and environmental changes that can alter cellular
disposition of drugs, notably by alterations of transmembrane drug transporters expression. Whether the
influx organic cation transporter 1 (OCT1) encoded by the gene SLC221A1 is implicated in the cellular
uptake of imatinib is still controversial. Besides, imatinib ionization state may be modulated by the hypoxic
acidic surrounding extracellular microenvironment.

Objective:

To determine the functional contribution of OCTs and extracellular pH on imatinib cellular
disposition.

Methods:

We measured imatinib uptake in two different models of selective OCTs drug transporter expression
(transfected Xenopus laevis oocytes and OCT-expressing HEK293 human cells), incubated at
pH 7.4 and 6, using specific mass spectrometry analysis.

Results:

Imatinib cellular uptake occurred independently of OCT1- OCT2- or OCT3-mediated drug
transport at pH 7.4. Uptake of the OCTs substrate tetraethylammonium in oocytes remained intact at
pH 6, while the accumulation of imatinib in oocytes was 10-fold lower than at pH 7.4, irrespectively of
OCTs expressions. In OCT1- and OCT2-HEK cells at pH 6, imatinib accumulation was reduced by 2-
3-fold regardless of OCTs expressions. Since 99.5% of imatinib at pH6 is under the cationic form, the
reduced cellular accumulation of imatinib at such pH may be explained by the lower amount of uncharged
imatinib remaining for passive diffusion across cellular membrane.

Conclusion:

Imatinib is not a substrate of OCTs 1-3 while the environmental pH modulates cellular
disposition of imatinib. The observation that a slightly acidic extracellular pH influences imatinib cellular
accumulation is important, considering the low extracellular pH reported in the hematopoietic leukemia/
cancer cell microenvironment.
Comparison of Effectiveness of Germania Honey Compared to Manuka Honey in Methicillin-Resistant Staphylococcus aureus (MRSA) Killing
Authors: Bazzi Ali M. , Rabaan Ali A. , Al-Tawfiq Jaffar A. , Shannak Bilal M.
Published: February 2019

Purpose:

Manuka honey is currently used in medical-grade sterile wound treatment products and has been shown to be effective in methicillin-resistant Staphylococcus aureus (MRSA) killing in vitro and in wound healing in a number of case studies and series. Locally produced honey in Pakistan and Chile have been proposed to be as effective as Manuka honey in bacterial killing in vitro, presenting potentially more accessible and affordable alternatives. In this study, we compared the effectiveness of a local Germania honey from Saudi Arabia to Manuka honey MGO 550 for in vitro killing of MRSA.

Methodology:

Overnight Muller Hinton broth cultures of 50 wound culture isolates of MRSA from 50 patients were incubated with a series of dilutions of Manuka honey MGO 550 and corresponding Germania honey dilutions for 24 h. Turbidity was assessed to determine whether bacterial growth had occurred, and no growth was confirmed by a further 24 h sub-culture on blood agar.

Results/Key findings:

Manuka honey MGO 550 was significantly more effective than Germania honey at MRSA killing at 100% v/v, 50% v/v and 25% v/v (p=0.025, 0.000265, and 0.000112 respectively)

Conclusion:

Manuka honey MGO 550 is significantly more effective in killing MRSA in vitro than Germania honey. Germania honey does not appear to be a promising locally produced alternative to Manuka honey for the development of honey-based wound dressings. Further experiments could determine if Germania honey is effective against other bacterial species.
Identification and Validation of Decision Factors for Selecting Smart Food Packaging Technology: A Case of Thailand’s Food Industry
Authors: Komonwatthanapong Wasana , Manuspiya Hathaikarn , Chandrachai Achara , Pandejpong Toryos
Published: February 2019

Background:

The growing urban lifestyle of consumers in Thailand has been driving demand for packaged convenience food. New trends in packaging technologiese.g.smart packaging, active technology, RFID.,etc.can be used as a business tool for a competitive advantage in the food industry to comply with consumer lifestyles.

Aims:

This paper aims to identify and validate the decision factors for selecting new trends of food packaging technology to support the food packaging industry in Thailand in producer firms’ viewpoints. Firstly, the author reviewed the literature to find out general factors in selecting any technologies to set guideline for design questions in questionnaires about decision factors in selecting food packaging. Secondly, the questionnaires were distributed to 40 representatives of food packaging firms in Thailand to find out their decision factors concerned. By the facts that the development of new trends of packaging in Thailand is mostly driven by only large firms. Hence, thirdly, the author performed in-depth interviews with executives in 8 leading and top largest food firms in Thailand to confirm that advanced packaging technology whether has opportunities of growth in the food industry in Thailand or not.

Results:

Respondents from food packaging firms in Thailand expressed their interests in four areas in selecting new technology of packaging, including (1) the technology aspect, (2) marketing and business competition aspect, (3) financial and economical aspect, and (4) strategy, society and environment aspect.

Conclusion:

A lack of raw materials and local technology still make the cost prohibitive to boom the advanced packing.
Polyp Shape Recovery from Single Endoscope Image using Medical Suture
Authors: Usami Hiroyasu , Iwahori Yuji , Wang Aili , Bhuyan M. K. , Ogasawara Naotaka , Kasugai Kunio
Published: February 2019

Background:

Polyp shapes play an important role in colorectal diagnosis. However, endoscopy images are usually composed of nonrigid objects such as a polyp. Hence, it is challenging for polyp shape recovery. It is demanded to establish a support system of the colorectal diagnosis system based on polyp shape.

Introduction:

Shape from Shading (SFS) is one valuable approach based on photoclinometry for polyp shape recovery. SFS and endoscope image are compatible on the first sight, but there are constraints for applying SFS to endoscope image. Those approaches need some parameters like a depth from the endoscope lens to the surface, and surface reflectance factor . Furthermore, those approaches assume the whole surface which has the same value of for the Lambertian surface.

Methods:

This paper contributes to mitigating constraint for applying SFS to the endoscope image based on a cue from the medical structure. An extracted medical suture is used to estimate parameters, and a method of polyp shape recovery method is proposed using both geometric and photometric constraint equations. Notably, the proposed method realizes polyp shape recovery from a single endoscope image.

Results:

From experiments it was confirmed that the approximate polyp model shape was recovered and the proposed method recovered absolute size and shape of polyp using medical suture information and obtained parameters from a single endoscope image.

Conclusion:

This paper proposed a polyp shape recovery method which mitigated the constraint for applying SFS to the endoscope image using the medical suture. Notably, the proposed method realized polyp shape recovery from a single endoscope image without generating uniform Lambertian reflectance.
Low Power Wide Fan-in Domino OR Gate Using CN-MOSFETs
Authors: Bansal Deepika , Nagar Bal Chand , Singh Brahamdeo Prasad , Kumar Ajay
Published: February 2019

Background & Objective:

In this paper, a modified pseudo domino configuration has been
proposed to improve the leakage power consumption and Power Delay Product (PDP) of dynamic
logic using Carbon Nanotube MOSFETs (CN-MOSFETs). The simulations for proposed and published
domino circuits are verified by using Synopsys HSPICE simulator with 32nm CN-MOSFET
technology which is provided by Stanford.

Methods:

The simulation results of the proposed technique are validated for improvement of wide
fan-in domino OR gate as a benchmark circuit at 500 MHz clock frequency.

Results:

The proposed configuration is suitable for cascading of the high performance wide fan-in
circuits without any charge sharing.

Conclusion:

The performance analysis of 8-input OR gate demonstrate that the proposed circuit provides
lower static and dynamic power consumption up to 62 and 40% respectively, and PDP improvement
is 60% as compared to standard domino circuit.
DRI Table Based Traffic-Behaviour Analysis Approach for Detection of Blackhole Attack
Authors: Juneja Kapil
Published: February 2019

Background:

The blackhole infection can affect the collaborative communication in mobile networks.
It is man-in-middle attack that seizes and deflects the route and avoids packet-forwarding in the network.
The occurrence of collaborative-blackhole reduces the trust and trustworthiness over the network.

Objective:

A probabilistic and weighted analysis based protocol is proposed in this research for detection
of cooperative blackhole nodes and generating the preventing route over the network. The aim of the
work is to improve the communication reliability.

Methods:

In this paper, the communication behaviour is analyzed under associated and probabilistic
measures using Data Routing Information (DRI) table to discover the blackhole attack. It applies a dual
check based on participation and communication constraints to estimate the node criticality. The evaluation
is performed by neighbours and neighbour-on-neighbour nodes with weights and threshold specific
decisions. These measures are evaluated through composite and integrated measures and presented as
decision metrics. The parametric and probabilistic checks are conducted as a comprehensive evaluation
within the proposed PSAODV (Probabilistic Secure Adhoc On Demand Distance Vector) protocol.

Results:

The simulation of PSAODV protocol is conducted in NS2 environment on various scenarios with
mobility, density and traffic type variations. The scenarios are defined with a higher density of blackhole
nodes within the network. The adaptive weights are identified by simulating the network with different
weight combinations. These weights are employed within the PSAODV protocol to configure it with the
maximum benefits. The analytical evaluations are taken against AODV and SAODV protocols and identified
the performance enhancement in terms of Packet Delivery Ratio (PDR) Ratio, delay, attack detection
ratio parameters.

Conclusion:

A significant improvement in attack detection is achieved by this proposed PSAODV protocol.
The proposed protocol improved the reliability and effectiveness of mobile network.
Development of LOCAL-IP based Environmental Condition Monitoring using Wireless Sensor Network
Authors: Mallik Avijit , Hossain Shaik Asif , Karim Asif Bin , Hasan Shahajada Mahmudul
Published: February 2019

Background & Objective:

In this paper, environmental monitoring system is implemented
using a wireless sensor networking (WSN) via a local internet protocol (IP) utilizing Wi-Fi media.
For enchanting data, DHT-11 (Temperature and Humidity sensor) and MQ-6 (LPG gas sensor) are
being used.

Methods:

The basic objective of this research is to monitor and to develop a real-time monitoring of
humidity and temperature, as well as the availability of gas using the very available DHT-11 sensor,
MQ-6 sensor, and ESP-8266 NodeMCU module and then observe the data from a local IP based
webpage.

Conclusion:

This paper also makes a compact distinction between conventional and the local IP
based observing system of an environment. The sensor's data are saved in an IP based webpage by
which we can monitor the sensor’s data without any access to the internet.
Investigating Structural Requirements of Some Pyrimidine-linked Benzimidazole Derivatives as Anticancer Agents Against MCF-7 Cancerous Cell Line Through the use of 2D and 3D QSARs
Authors: Mayura Kale , Sharuk Khan , Jyoti Hature
Published: February 2019

Background:

Cancer is an extremely fast, unrestrained and pathological propagation
of cells. Yet there is no cancer treatment that is 100% efficient against scattered cancer.
Heterocycles have been considered as a boon to treat several cancers of which pyrimidine is
a core nucleus and holds an important place in cancer chemotherapy which is reflected in the
use of drugs such as 5-fluorouracil, erlotinib, gefitinib and caneratinib. Also, many good antitumor
active agents possess benzimidazoleas its core nucleus.

Objective:

To design novel pyrimidine-linked benzimidazoles and to explore their structural
requirements related to anticancer potential.

Methods:

2D and 3D Quantitative structure–activity relationship (QSAR) studies were carried
out on a series of already synthesized 27 pyrimidine-benzimidazole derivatives.

Results:

Statistically significant and optimum 2D-QSAR model was developed by using
step-wise variable multiple linear regression method, yielding correlation coefficient r2 =
0.89, cross-validated squared correlation coefficient q2 = 0.79 and external predictive ability
of pred_r2 = 0.73 Best 3D-QSAR model was developed by employing molecular field analysis
using step-wise variable k-nearest neighbor method which showed good correlative and
predictive abilities in terms of q2 =0.77 and pred_r2= 0.93.

Conclusion:

These 2D and 3D models were found to give dependable indications which
helped to optimize the pyrimidine-benzimidazole derivatives of the data set. The data yielded
by 2D- QSAR and 3D-QSAR models will aid in giving better perceptions about structural
requirements for developing newer anticancer agents.
Human-Centered Design for Women’s Health Screening Tool Redevelopment: Participant Experiences (Preprint)
Authors: Ostrach Bayla
Published: February 2019

BACKGROUND

Human-Centered Design (HCD) is an innovation or design process that emphasizes collective input from stakeholders. A growing body of literature examines the science of patient and community engagement in health research yet little qualitative research to date examines how community members recruited to collaborate on designing health practice variations and delivery of care perceive and experience such a process.

OBJECTIVE

Examine perceptions of a Human-Centered Design process as an engagement tool to inform delivery of care and practice innovation in women’s health screening.

METHODS

Primary qualitative data collected at a medical education center/network of clinics, and in the surrounding community. Qualitative study used opportunistic and purposive sampling recruiting participants from an earlier HCD process undertaken to redesign screening tools. Participants were purposively and sampled from among eligible participants who participated in the Human-Centered Design process to develop women’s health screening tools and who were community members and/or clinicians/clinical staff. All eligible participants who agreed to participate were interviewed using a semi-structured, open-ended guide. Interviews were audio-recorded, transcribed, hand-coded, and analyzed using modified Grounded Theory.

RESULTS

Community members and clinicians reported divergent views of the HCD process; both groups valued the opportunity to participate. Some found the process easy to engage; others found it confusing or even embarrassing.

CONCLUSIONS

Community members and clinicians valued being part of determining the best process for healthcare delivery and practice innovation or variation; concerns remained about access to and full participation in the process. Though a promising option and valuable process, the HCD process was not equally comfortable or accessible for all. Community engagement beyond the clinical team to developing practice variation is important but must be undertaken thoughtfully.

CLINICALTRIAL

Not applicable
How the ICT (Information and Communication Technology) Influences Work and Private Life
Authors: Novak David
Published: February 2019

The purpose is about the influence of ICT on increasing the efficiency and performance of employees, the workload and the increasing complexity of the requirements and the constantly increasing pressure to perform at all employee levels.

The used methodology is as follows: An evaluation of the scientific literature is carried out here. The point of departure of the considerations is the fact that the ICT changes the world and with it also the professional and private life of the users.

The results of the analysis show a constantly changing environment, which is both cause and effect of the changes.

The influence of the ICT on people is given, no matter if it concerns direct users or indirect affected persons. This relationship must be realized and further investigated. Employers should generally note that the actual work changes massively for their own employees. Interestingly, it does not play a significant role in how far they systematically deal with hardware and software. Future research has to deal much more with the consequences of constantly changing boundary conditions. This includes the efficiency measurement through ICT use, which is completely missing so far.

The ICT has a massive impact on all people, regardless of whether they like it or not and whether or not they handle it themselves.
Prescription Patterns of Antidepressants: The Effect of the Black Box Warning among Pediatric Patients
Authors: Sher H. , Perry Z.H. , Arbel S. , Reuveni H.
Published: February 2019

Introduction: Our aim was to investigate the prescription patterns of antidepressant in the southern Israel during the years 2000 to 2005, before and after the FDA black box warning issued regarding the prescription of antidepressants in children.

Patients and methods: A cross sectional study. Data regarding prescription of anti-depressant drugs was examined retrospectively. All information was obtained from the computerized databases of the Clalit Health care services, southern county. Data was analyzed by using descriptive statistics, and analytical statistics. Multi-variate analysis was performed when applicable.

Results: When comparing the prescription rate of fluoxetine and fluvoxamine versus other SSRI’s included in the health agencies warnings during the years mentioned, there was a gradual increase in the percentage of the other SSRI’s until 2003 from 12.2% in 2000 to 64.2% in 2003 and then a reversal of this trend from 51.9% in 2004 to 47.8% in 2005.
Discussion and conclusions: This study shows that the CSM advice has not had a significant effect in reversing the rising prevalence of antidepressant prescribed to children and adolescents in primary care. It has however changed the choice of antidepressant medication chosen within the group of SSRI’s.
La instrumentalización política del espacio público y la condición ideológica de una geopolítica de la razón. Narrativas y subjetividades neoliberales desde la Ciudad de México
Authors: Filipe Narciso Carla
Published: February 2019

En los últimos 20 años, el concepto de espacio público se ha vuelto dominante tanto en los discursos gubernamentales como académi- cos, sobre todo en regímenes políticos progresistas y democráticos de América Latina, y que dado su arbitrio ideológico y abstracto de lo pú- blico, del orden democrático y de la opinión pública moderna, ha sido determinante como marco legitimador de prácticas geopolíticas y dis- cursos hegemónicos que determinan un status quo que ha permitido al sistema capitalista seguir reproduciendo a partir de las estructuras urbanas y el desarrollo urbanístico. Por consiguiente, el presente tra- bajo procura reflexionar sobre la forma como se ha espacializado la instrumentalización del concepto a partir de las relaciones de poder, el desarrollo urbano neoliberal y las nuevas dinámicas de acumulación de capital en la Ciudad de México.
Clasificación de los conceptos jurídicos I
Authors: García Máynez Eduardo
Published: February 2019

Clasificación de los conceptos jurídicos I
Catolicismo y modernismo en la conciencia iberoamericana
Authors: Zea Leopoldo
Published: February 2019

Catolicismo y modernismo en la conciencia iberoamericana
La metafísica de Empédocles
Authors: García Díaz Adolfo
Published: February 2019

La metafísica de Empédocles
José Ortega y Gasset: algunos temas capitales de su filosofía
Authors: Recaséns Siches Luis
Published: February 2019

José Ortega y Gasset: algunos temas capitales de su filosofía
Leopoldo Zea, La filosofía en México
Authors: Villegas Abelardo
Published: February 2019

Leopoldo Zea, La filosofía en México
Armando Correia Pacheco, Ensayistas del Brasil. Escuela de Recife
Authors: Villegas Abelardo
Published: February 2019

Armando Correia Pacheco, Ensayistas del Brasil. Escuela de Recife
Ph. Wheelwright, The Burning Fountain. A Study in the Language of Symbolism
Authors: Bueno Miguel
Published: February 2019

Ph. Wheelwright, The Burning Fountain. A Study in the Language of Symbolism
Louis de Broglie, La physique quantique restera-t-elle indéterministe?
Authors: De Gortari Eli
Published: February 2019

Louis de Broglie, La physique quantique restera-t-elle indéterministe?
La sabiduría en Aristóteles
Authors: Gómez Robledo Antonio
Published: February 2019

La sabiduría en aristóteles
Algunas aclaraciones sobre el Contrato Social de Rousseau
Authors: Recaséns Siches Luis
Published: February 2019

Algunas aclaraciones sobre el Contrato Social de Rousseau
Sobre el método de la filosofía
Authors: Abbagnano Nicola
Published: February 2019

Sobre el método de la filosofía
Los comienzos de la teoría europea del Derecho y del Estado en Hesíodo
Authors: Von Verdross Alfred
Published: February 2019

Los comienzos de la teoría europea del Derecho y del Estado en Hesíodo
Platón. La teoría del Estado justo
Authors: Llambías de Azevedo Juan
Published: February 2019

Platón. La teoría del Estado justo
El historicismo y el problema de la verdad
Authors: Frondizi Risieri
Published: February 2019

El historicismo y el problema de la verdad
Louis Rougier, Traité de la Connaissance
Authors: García Máynez Eduardo
Published: February 2019

Louis Rougier, Traité de la Connaissance
Ernesto Mayz Vallenilla, Fenomenología del conocimiento. El problema de la constitución del objeto en la filosofía de Husserl
Authors: Villoro Luis
Published: February 2019

Ernesto Mayz Vallenilla, Fenomenología del conocimiento. El problema de la constitución del objeto en la filosofía de Husserl
Evert W. Beth, Les fondements logiques des mathémathiques
Authors: De Gortari Eli
Published: February 2019

Evert W. Beth, Les fondements logiques des mathémathiques
M. Rosental, Voprosi dialectiki v "Kapitale" Marxa (Los problemas de la dialéctica en "El Capital" de Marx)
Authors: Sánchez Vázquez Adolfo
Published: February 2019

M. Rosental, Voprosi dialectiki v "Kapitale" Marxa (Los problemas de la dialéctica en "El Capital" de Marx)
Mario Bunge, La edad del universo
Authors: De Gortari Eli
Published: February 2019

Mario Bunge, La edad del universo
Antonio Gómez Robledo, Filosofía y lenguaje
Authors: Recaséns Siches Luis
Published: February 2019

Antonio Gómez Robledo, Filosofía y lenguaje
Paulo Dourado de Gusmão, Introdução a Ciencia do Direito
Authors: Recaséns Siches Luis
Published: February 2019

Paulo Dourado de Gusmão, Introdução a Ciencia do Direito
Winfried Menninghaus, Saber de los umbrales. Walter Benjamin y el pasaje del mito, trad. Mariela Vargas y Martín Simensen de Bielke, Biblos, Buenos Aires, 2013, 135 pp.
Authors: Quijano Omar
Published: February 2019

Las reseñas no incluyen resumen.