bluuebunny/crossref_metadata_2025 huggingface dataset:
An extended transcription factor regulatory network controls hepatocyte identity
Authors: Dubois‐Chevalier Julie , Gheeraert Céline , Berthier Alexandre , Boulet Clémence , Dubois Vanessa , Guille Loïc , Fourcot Marie , Marot Guillemette , Gauthier Karine , Dubuquoy Laurent , Staels Bart , Lefebvre Philippe , Eeckhoute Jérôme
Published: July 2023

Cell identity is specified by a core transcriptional regulatory circuitry (CoRC), typically limited to a small set of interconnected cell‐specific transcription factors (TFs). By mining global hepatic TF regulons, we reveal a more complex organization of the transcriptional regulatory network controlling hepatocyte identity. We show that tight functional interconnections controlling hepatocyte identity extend to non‐cell‐specific TFs beyond the CoRC, which we call hepatocyte identity (Hep‐ID)CONNECT TFs. Besides controlling identity effector genes, Hep‐IDCONNECT TFs also engage in reciprocal transcriptional regulation with TFs of the CoRC. In homeostatic basal conditions, this translates into Hep‐IDCONNECT TFs being involved in fine tuning CoRC TF expression including their rhythmic expression patterns. Moreover, a role for Hep‐IDCONNECT TFs in the control of hepatocyte identity is revealed in dedifferentiated hepatocytes where Hep‐IDCONNECT TFs are able to reset CoRC TF expression. This is observed upon activation of NR1H3 or THRB in hepatocarcinoma or in hepatocytes subjected to inflammation‐induced loss of identity. Our study establishes that hepatocyte identity is controlled by an extended array of TFs beyond the CoRC.
Longitudinal trajectories of maternal TSH in healthy pregnant women in Catalonia
Authors: Soldevila Berta , Velasco Inés , Muñoz Carla , Díaz Yesika , Egea-Cortés Laia , Ferrer-Escopiñan Laura , Pérez-Montes de Oca Alejandra , Martínez-Mondejar Raquel , Casabona Jordi , Puig-Domingo Manel
Published: July 2023

Objective

Longitudinal evaluation of thyroid function throughout pregnancy in the same subject could offer precise information about its dynamics as a physiological mechanism of adaption to the requirements. In this study, we evaluated longitudinal trajectories of maternal thyroid function during pregnancy by a latent class growth analysis and explored their association with maternal–fetal outcomes.

Methods

A prospective observational study was carried out, including 414 healthy pregnant women, from the first trimester to delivery. Thyroid function and autoimmunity were measured in the three trimesters. Clinical data during pregnancy were obtained. Longitudinal mixed model techniques were performed to explore trajectories of gestational thyroid function.

Results

Three different longitudinal trajectories were obtained from maternal thyrotropin (TSH) levels: low-increasing TSH (class 1) in 86% of cases, high-increasing TSH (class 2) in 9.7%, and decreasing TSH (class 3) in 4.3%. No statistical differences in free thyroxine levels were found among the three classes. Differences in maternal age (P = 0.027) and initial maternal weight (P = 0.043) were observed among the groups. In logistic regression analysis, maternal age correlated with longitudinal trajectories. The three longitudinal classes remain when women with thyroid autoimmunity (TAI) are excluded. Multinomial logistic regression showed maternal age correlated with longitudinal trajectories independently of TAI status.

Conclusions

Three differentiated TSH trajectories were found in healthy pregnant women living in Catalonia, as previously described. No association with obstetric outcomes was observed in these different chronological thyroid pathways, but maternal age might condition the longitudinal mechanism of thyroid function regulation throughout pregnancy.
МОДИФІКАЦІЯ ДОКУМЕНТУВАННЯ У КОНТЕКСТІ ЦИФРОВІЗАЦІЇ БУХГАЛТЕРСЬКОГО ОБЛІКУ
Authors: Shkromyda V.V. , Shkromyda N.Ya. , Gnatyuk T.M.
Published: July 2023

В статті розглянуто зміни і доповнення, які виникають у процесі документування бізнес-процесів на підприємстві у контексті цифровізації бухгалтерського обліку і звітності. Завдяки швидкому розвитку технологій та впровадженню цифрових інструментів, бухгалтерія перетворюється з традиційного паперового процесу в автоматизовану електронну систему, яка приносить ряд переваг в управлінні підприємством. До ключових переваг цифровізації бухгалтерського обліку слід віднести точність облікових даних, зручний і швидкий доступ до них, а також високий рівень захисту і безпеки.

Позитивним аспектом на рівні держави є те, що у напрямку використання цифрових технологій в обліку і звітності прийнято низку законодавчих актів. Це створює сприятливу базу для розгортання та прискорення процесу цифрової трансформації у сфері бухгалтерського обліку і фінансової звітності, а також економічних взаємовідносин. В умовах цифровізації обліку і звітності спостерігається розширення реквізитів електронних облікових документів, яких раніше не існувало у паперовому форматі. Цей процес супроводжується перенесенням документообігу до віртуального простору. За допомогою розширених метаданих електронний формат надає можливість в реальному часі та оперативно змінювати структуру, зміст та порядок оформлення документів. Крім того, цифровізація бухгалтерського обліку покращує умови для організації документообігу у підприємстві. Вона дозволяє застосовувати об'єктноорієнтований підхід до побудови документообігу, що означає, електронні документи можуть переміщатись як вертикально (по ієрархічній ланці підтвердження), так і горизонтально (між різними відділами та структурними підрозділами). Це дає змогу оперативно адаптувати маршрути проходження документів в залежності від об'єктів, що документально оформлюються, та виробничих потреб, які змінюються на підприємстві.

Отримані наукові результати сприятимуть розвитку теоретико-методичної основи процесу оцінювання ефективності впровадження цифрового документування на підприємстві та пошуку шляхів покращення оперативності і надійності обліково-аналітичної інформації.
Layer-by-layer nanoscale bondlines for macroscale adhesion
Authors: Zhou Yu , Renneckar Scott , Pillai Karthik V. , Li Qingqing , Lin Zhiyuan , Church W. Travis
Published: July 2023

The objective of this study was to test the bonding performance of nanoscale bondlines, which were fabricated with polyelectrolytes by layer-by-layer assembly process onto wooden substrates. In this study, environmental scanning electron microscopy (ESEM) was used to characterize adsorbed multilayers of polyacrylic acid and polyallylamine hydrochloride on the wood surface. Cross-linking between PAA and PAH layers at various temperatures was studied using Fourier Transform Infrared Spectroscopy (FTIR). The evaluation of polyelectrolyte multilayers as bonding agents for wood was conducted through compression shear block and flexural bending tests. Altogether, this research demonstrates a route to utilize nanoscale coatings as bonding agents.
Soda-anthraquinone pulp from Malaysian cultivated kenaf for linerboard production
Authors: Azizi Mossello Ahmad , Harun Jalaluddin , Resalati Hossein , Ibrahim Rushdan , Md Tahir Paridah , Fallah Shamsi Seyed Rashid , Mohamed Ainun Zuriyati
Published: July 2023

The goal of this study was to prepare soda- anthraquinone pulp from kenaf whole stem and to compare the resultant core and bast pulps for linerboard production. Pulping was done under mild cooking conditions (active alkali 12-15%) with a cooking time of 30-90 min and a temperature of 160ºC. During the pulping process, kappa numbers ranged from 56.0 to 20.6, while total yields varied from 58.4 to 54.2% with a rejection rate of 2.3 to 0.1%. Based on the quality of pulp produced, kappa numbers 49.4 and 25.4 was selected as symbolic of high and low pulps respectively. The results of the study revealed significant difference between the properties of core, whole stem (KHK and KLK), and bast pulps. Core pulps with low freeness and high drainage time the study found produced sheets with greater density, tensile index, burst index and RCT, with lower light scattering coefficient and tear index than bast pulp. Whole stem pulps showed properties between those of core and bast pulps. Moreover, KLK with high drainage time produced papers with significantly higher strength properties than KHK.
Enhanced biodegradation of pulping effluents by a statistical experimental design using microbial consortia
Authors: Chen Honglei , Chen Yuancai , Zhan Huaiyu , Fu Shiyu
Published: July 2023

Statistically based experimental designs were used to construct a mixed-culture community for maximizing the chemical oxygen demand (COD) degradation of pulping effluents by the use of six different strains, i.e., Agrobacterium sp., Bacillus sp., Enterobacter cloacae, Gordonia, Pseudomonas stutzeri, and Pseudomonas putida. Significant effects of single and mixed strains on COD degradation were quantified first by applying a fractional factorial design (FFD) of experiments, and four strains were selected as the main driving factors in the process of biodegradation of effluents. Then the Steepest Ascent method was employed to approach the experimental design space, followed by an application of response surface methodology to further optimize the proportion of cell concentration for different strains in pulping effluent. A quadratic model was found to fit COD removal efficiency. Response surface analysis revealed that the optimum levels of the tested variables for the degradation of COD, and optimized cells concentrations (OD600) of four strains in mixed-culture community were 0.35 Agrobacterium sp., 0.38 Bacillus sp., 0.43 Gordonia sp., and 0.38 P. putid., respectively. In a confirmatory experiment, three test runs were performed by using the optimized conditions, and a COD removal efficiency of (65.3 ± 0.5)% was observed, which was in agreement with the prediction.
The effects of several non-oxidizing biocides on fine paper wet-end chemistry
Authors: Huber Patrick , Carré Bruno , Zeno Elisa
Published: July 2023

Biocide programs have become necessary in most fine paper manufacturing circuits, as drastic reduction of fresh water consumption in the industry enhances microbial development. Depending on their chemical nature, biocides may interfere with typical wet-end chemistry additives and furnish. A reference wet-end chemistry was set (including fixing aid, dry strength aid, sizing agent, and retention system), then biocides were added to the furnish (bleached virgin fibres + mineral filler) prior to handsheet making. Four of the tested biocides (organo-sulfur, dibromonitrilopropionamide, isothiazoline, and glutaraldehyde) were not found to interact with wet-end chemistry. On the other hand, the tested quaternary ammonium salt biocide showed very detrimental effects: it reduced filler retention in the sheet, decreased sheet strength, and destroyed sizing (sheet hydrophobicity).
Solid state fermentation and characterization of partially purified thermostable mannanase from Bacillus sp. MG-33
Authors: Meenakshi  , Singh Gursharan , Bhalla Aditya , Hoondal Gurinder Singh
Published: July 2023

Bacillus sp. MG-33 was isolated from the desert of Rajasthan (India). The organism produced 500 and 200 Ug-1 of thermostable mannanase (after 96h) in solid state fermentation (SSF) of wheat bran and wheat straw rich-soda pulp at the moisture ratio of 1:1.5 and 1:3 at 30ºC, respectively. Two-step partially purified mannanase was optimally active at 65ºC and was 100% thermostable at 55 to 60ºC for 2h and also retained more than 50% residual activity at 65ºC for 2h. A pH of 6.5 was optimum for enzyme activity and 100% stability up to 4h at this pH. Mannanase activity was slightly enhanced by Ca2+, Fe3+, and Mg2+, while 100% activity was retained in the presence of Ba3+, Li+, and NiCl2 at 1.0-10mM. 1M NaCl and urea did not reduce the enzyme activity. The Km and Vmax of mannanase were 0.2mgml-1 and 60Umg-1ml-1, respectively. Hydrolysis of locust bean was rapid and linear between 5 and 20 min, and ~300µgml-1 mannose was obtained after 20 min of catalytic reaction by enzyme at 65ºC. TLC was used to confirm the mannose as an end product after hydrolysis of locust bean gum.
Applied study of birch pulp bleaching using dimethyldioxirane to obtain acetate-grade pulp
Authors: Zhou Shuke , Yao Sheng , Xing Mian , Pu Junwen
Published: July 2023

As a pulp bleaching agent, dimethyldioxirane (DMD) is effective and selective. In this study, it was employed as a delignifying agent or as an activating agent for hydrogen peroxide treatment in bleaching acetate-grade pulp. Brightness, kappa number, degree of polymerization (DP), and alpha-cellulose content were evaluated to determine the optimal charges of DMD: 2.5% AO, and 4% HSO5-, respectively. Results from the totally chlorine-free (TCF) sequences MEQMPA, MEpQMPA, and OQMPA suggested that DMD is both effective and selective as a delignifying agent but not as a brightening agent as compared to oxygen. And in a long sequence for the bleaching of dissolving pulp, acid treatment can be used in two approaches: to remove the metal ions without washing before the chelation stage, and to reduce hemicellulose and ash in the final stage.
Study on lignin coverage of masson pine fiber
Authors: Wang Baoyu , He Beihai , Li Junrong
Published: July 2023

In order to obtain the adhesion force of fiber in a paper sheet easily, the relationships between internal bonding strength (IBS) and surface lignin content of masson pine CTMP treated with peracetic acid (PAA) have been investigated with XPS technique, and the surface morphology of fibers was also imaged by AFM. The results showed that the extent of lignin covered on the fiber surface was two times as high as that of whole pulp lignin, and the IBS was inversely proportional to surface lignin. The relationship between IBS and lignin coverage was formulated based on the experimental data. The mutual adhesion forces, cellulose-to-cellulose and lignin-to-lignin, were calculated using these equations, and the results were 28.69 mN/m and 2.487mN/m, respectively.
Prevalence of anxiety and depression of health care workers during COVID-19 – a systematic review and meta-analysis
Authors: Sialakis Christos , Antoniou Sialaki Panagiota , Frantzana Aikaterini , Iliadis Christos , Ouzounakis Peter , Kourkouta Lambrini
Published: July 2023

Introduction. During the COVID-19 pandemic, the workload of healthcare workers managing the disease, increased significantly. The objective of this review is to determine the anxiety and depression prevalence among healthcare workers during the pandemic period.
Methods. We searched systematically the literature in five electronic databases such as PubMed, CINAHL, ScienceDirect, MEDLINE, and Cochrane COVID-19 study register. The last online research was performed in May 2022. We included only cross-sectional studies and performed a meta-analysis of pooled prevalence. Publication bias was assessed with a funnel plot and Egger’s and Begg’s tests. A random effect was applied and heterogenicity I2 was calculated. Quality assessment of included studies was performed using the Joanna Briggs Institute tool.
Results. In this review, we included 14 cross-sectional studies comprising 7780 healthcare workers. Participants were from the whole spectrum of healthcare workers. The pooled prevalence of depression was 33.8% (95% CI: 24.6 – 43.6), heterogenicity I2: 98.69% . The pooled prevalence of anxiety was 41.3% (95% CI: 30.2 – 52.9), heterogenicity I2: 99.01%.
Conclusion. One-third of healthcare workers suffered from depression, and more than one-third suffered from anxiety during the COVID-19 pandemic. Increased measures of surveillance of mental health should have been taken, as well as the support of healthcare workers running a high risk of psychological distress during the COVID-19 pandemic.
The monthly average distributions of sea-surface wind speeds and directions in the East Vietnam Sea
Authors: Vu Van Tac
Published: July 2023

This paper analyzes a monthly global gridded sea-surface wind dataset from Jan 1991 to Dec 2020, sourced from the International Comprehensive Ocean-Atmosphere Data Set (ICOADS). The goal is to construct schematic maps depicting the monthly average distributions of sea-surface wind speeds and directions in the East Vietnam Sea. These maps provide a visual representation of the monsoon patterns at different points and areas in the region. The statistical and analytical findings reveal that the East Vietnam Sea is primarily influenced by two types of monsoons: Northeast and Southwest. When one is strong, the other is weak, and vice versa. The Northeast monsoon dominates from September to April of the following year, while the Southwest monsoon is more dominant from May to August. The intensity of the Northeast monsoon is usually greater than that of the Southwest monsoon. These results provide an overview of the monsoon distributions in the East Vietnam Sea, which can assist scientists and managers in proposing policies and measures suitable to the climate environment and wind seasons. These findings also help in the effective exploitation of abundant wind energy resources in coastal Vietnam and the East Vietnam Sea. Furthermore, the results are consistent with previous studies of monsoons in the East Vietnam Sea, indicating that the data source used in this study is reliable and can be utilized as input data for tidal, currents, or oil spread models.
Assessing the significance of some biomarkers in perioperative period after thoracic aortic reconstruction
Authors: Akselrod B. A. , Dymova O. V. , Gubko A. V. , Krasnoshchekova A. P. , Guskov D. A. , Goncharova A. V. , Gladysheva V. G. , Gubko K. V. , Kulinchenko O. S.
Published: July 2023

Aim. This study aims to assess the association between levels of biomarkers and postoperative complications in patients after thoracic and thoracoabdominal aortic reconstruction.

Material and methods. This study included 132 patients. The most of them underwent ascending aortic and aortic arch reconstruction (65 and 57, respectively).

The concentrations of proadrenomedullin, presepsin, procalcitonin, troponin I and N-terminal brain natriuretic peptide were measured before induction anesthesia, at the end of the surgical operation and in 6 hours after surgery.

Results. 69 patients had postoperative complications. Among them, inflammatory (27,3%) and cardiovascular complications (12,1%) prevailed. At the end of the surgical operation, the levels of the biomarkers in patients without postoperative complications and with postoperative complications were for presepsin 326 [206; 451] и 620 [332; 829] p<0,00001, tropononin I 0,77 [0,46; 1,39] and 1,49 [0,59; 3,39], p=0,01, proadrenomedullin 0,894 [0,683; 1,221] and 1,201 [0,944; 1,762], p=0,0002, procalcitonin 0,206 [0,147; 0,452] and 0,563 [0,307; 2,107], p=0,0002, respectively. According to log-linear regression model, the level of prepepsin at the end of the surgical operation >459,5 (odds ratio (OR) 6,84, 95% confidence interval (CI): 3,14-14,87) or proadrenomedullin >0,788 (OR 5,47, 95% CI: 1,52-19,68) are associated with the increased risk of postoperative complications. The level of presepsin >519,5 pg/ml at the end of the surgical operation (OR 4,55, 95% CI: 1,97-10,47) is associated with the increased risk of inflammatory complications. Regarding the prognosis of the risk of prolonged cardiotonic drug infusions, threshold values for troponin were >1,04 at the end of the surgical operation (sensitivity 75%, specificity 71,3%, AUC 0,785), >1,57 in 6 hours after surgery (sensitivity 81,3%, specificity 71,6%, AUC 0,794).

Conclusion. High levels of presepsin at the end of the surgical operation may be useful to predict the postoperative complications in patients who underwent the aortic surgery however, the low levels of presepsin do not exclude the development of postoperative complications. The increased level of troponin I at the end of the surgical operation and in 6 hours after surgery can be a predictor of the need for cardiotonic support in the postoperative period.
Single-stent strategy for left coronary artery bifurcation lesions in patients with chronic ischemic heart disease: protocol of a randomized trial
Authors: Khokhlunov S. M. , Salamov G. V. , Kislikhin Т. V. , Kostyrin E. Yu. , Tumanov A. I. , Titov A. L. , Patrikeeva A. A.
Published: July 2023

Aim. This study aims to compare the intraoperative, immediate postoperative and long-term postoperative results of stenting followed by final kissing balloon angioplasty (FKB) and without FKB for left coronary artery (LCA) bifurcation lesions in patients with chronic ischemic heart disease.

Material and methods. We plan to perform an open-label, prospective, randomized, single-center, cohort trial that will include 40 patients with left main coronary artery bifurcation lesion, who will undergo stenting procedure followed by FKB or without FKB, using the second-generation drug-eluting stents. Randomization into two groups will be done after performing coronary angiography, confirming the inclusion criteria and the absence of non-inclusion criteria and signing a written consent in 2 copies. Group 1 — stenting followed by FKB. Group 2 — stenting without FKB. The total follow-up period is 24 weeks. It is planned to contact by phone on 30th and 180th day (±7 days) of postoperative period to obtain the information about patient condition, general survival rate, the events of combined controlled points and drug therapy. During 2d phone contact, on 180th day (±7 days), a patient will be invited to undergo multispiral computed tomography of the coronary arteries.

The primary combined end-point: cardiac death, nonfatal myocardial infarction, acute cerebrovascular accident and the repeat target vessel revascularization. The secondary combined end-point: thrombosis and stent restenosis.

Conclusion. Our study will optimize the approach to the choice of stenting strategy (with or without FRB) for left main coronary artery bifurcation lesions in patients with chronic ischemic heart disease.
Association of cystatin C with changes of left ventricular structure and function in individuals with different cardiovascular risk
Authors: Murkamilov I. Т. , Fomin V. V. , Sabirov I. S. , Yusupov F. A.
Published: July 2023

Aim. This study aims to investigate the association of cystatin C with changes of left ventricular structure and function in individuals with different cardiovascular risk (CVR).

Material and methods. 267 patients with low-moderate (group I, n=58), high (group II, n=80) and extremely high (group III, n=129) CVR were examined. The level of serum cystatin C, creatinine and blood lipid spectrum, filtration rate of the kidneys and echocardiography indicators were estimated.

Results. Among all the study participants (n=267), 194 patients (72,6% of cases) had the increased level of serum cystatin C; 165 patients (61,7% of cases) showed the signs of the left ventricular hypertrophy (LVH). The increased level of serum cystatin C was observed in 51,7% of cases in group I; 75,0% — in group II and 80,6% — in group III. The values of glomerular filtration rate (GFR) calculated using the CKD-EPI and F. Hoek formula were the following: 100,2±17,0 ml/min/1,73 m2 and 84,8±15,5 ml/min/1,73 m2, p<0,05 in group I; 81,2±21,6 ml/min/1,73 m2 and 63,1±18,3 ml/min/1,73 m2, p<0,05 in group II; 63,0 (32,0;93,0) ml/min/1,73 m2 and 55,1 (22,1;70,7) ml/min/1,73 m2 — in group III. The LVH detection increased with the increase of the CVR degree (43,1% — in group I; 66,2% — in group II and 67,4% in group III). Relative wall thickness (RWT, units) increased significantly from the patients of group I (0,34±0,04 units) to the patients of group II (0,37±0,08 units) and III (0,38±0,06 units). Eccentric variant of LVH significantly prevailed in all the groups. On one side, it was found that the level of serum cystatin C was in direct correlation with left ventricular mass index (LVMI, r=0,268, p<0,05) and left ventricular RWT (r=0,190, p<0,05), and on the other side, the inverse relationship between LVMI and GFR for cystostatin C was observed (r=-0,324, p<0,05).

Conclusion. The results of the study showed that the level of serum cystatin C and LVMI value significantly increase with the increase of the CVR degree. The high levels of serum cystatin C are closely associated with the increase of LVMI and the changes in the RWT value. In turn, the increase of LVMI negatively correlated with filtration rate of the kidneys in patients with different CVR. Concerning the structural changes in the left ventricle, eccentric HLV prevailed in all the three groups.
EARLY POSTOPERATIVE OUTCOMES OF THE ESOPHAGECTOMY MINIMALLY INVASIVE IN ESOPHAGEAL CANCER
Authors: Francischetto Thiago , Pinheiro Vaner Paulo da Silva Fonseca , Viana Eduardo Freitas , Moraes Eduardo Dias de , Protásio Bruno Mendonça , Lessa Marco Antônio Oliveira , Almeida Gustavo Lousado de , Barretto Victor Rivera Duran , Albuquerque Alexandre Farias de
Published: July 2023

ABSTRACT BACKGROUND: The incidence of esophageal cancer is high in some regions and the surgical treatment requires reference centers, with high volume, to make surgery feasible. AIMS: To evaluate patients undergoing minimally invasive esophagectomy by thoracoscopy in prone position for the treatment of esophageal cancer and to recognize the experience acquired over time in our service after the introduction of this technique. METHODS: From January 2012 to August 2021, all patients who underwent the minimally invasive esophagectomy for esophageal cancer were retrospectively analyzed. In order to assess the factors associated with the predefined outcomes as fistula, pneumonia, and intrahospital death, we performed univariate and multivariate logistic regression analyses, accounting for age as an important factor. RESULTS: Sixty-six patients were studied, with mean age of 59.5 years. The main histological type was squamous cell carcinoma (81.8%). The incidence of postoperative pneumonia and fistula was 38% and 33.3%, respectively. Eight patients died during this period. The patient's age, T and N stages, the year the procedure was performed, and postoperative pneumonia development were factors that influenced postoperative death. There was a 24% reduction in the chance of mortality each year, associated with the learning curve of our service. CONCLUSIONS: The present study presented the importance of the team's experience and the concentration of the treatment of patients with esophageal cancer in reference centers, allowing to significantly improve the postoperative outcomes.
Privacidade no século 21: proteção de dados, democracia e modelos regulatórios
Authors: Meireles Adriana Veloso
Published: July 2023

Resumo: A partir da teoria política sobre a distinção público privado, o artigo investiga a proteção de dados pessoais como um desdobramento contemporâneo da privacidade. Para fundamentar empiricamente a discussão, são analisados três diferentes marcos normativos de proteção de dados: da União Europeia, dos Estados Unidos e do Brasil. O objetivo é examinar como as legislações compreendem o papel do Estado, a atuação do setor privado e os direitos de seus cidadãos. A metodologia adotada é a de análise comparada com foco nas correlações e controvérsias entre as normas. Como resultado, o artigo sistematiza as principais regras adotadas em cada uma das regiões em um quadro comparativo. O diagnóstico aponta para a conclusão de que as divergências entre os modelos regulatórios refletem entendimentos sobre o próprio sistema democrático. Os resultados da discussão buscam contribuir para reflexões das ciências sociais com ênfase em tecnologia e política.
Indicadores de mobilização de capacidades do pensamento crítico em estudantes do Ensino Médio
Authors: Cher Gabriela Gonzaga , Silveira Marcelo Pimentel da , Passos Marinez Meneghello
Published: July 2023

Resumo Neste artigo trazemos os resultados de uma investigação que objetivou elaborar uma unidade didática temática (UDT) acerca dos plásticos, tendo como eixo norteador os pressupostos do Pensamento Crítico (PC) e sua posterior aplicação em uma turma do Ensino Médio. Após a aplicação, investigou-se o potencial deste material em mobilizar as capacidades do PC nos estudantes e quais foram seus possíveis indicadores. Este artigo está centrado na releitura e reorganização de dados oriundos da aplicação da UDT, delimitando-nos na análise de uma etapa que intentava mobilizar a capacidade de fazer e responder a questões de clarificação. Tal processo conduziu-nos a assumir duas categorias a priori, intituladas Fatos e Exemplos e a emergência de 19 subcategorias, as quais foram compreendidas como indicadores da mobilização da capacidade do PC. A UDT revelou possuir potencial em mobilizar tal capacidade do PC em razão do material didático-pedagógico ter sido intencionalmente planejado para este fim.
Estágio Supervisionado Obrigatório em Ciências Biológicas durante o Ensino Remoto Emergencial
Authors: Barreto Edna Silva , Araújo Monica Lopes Folena
Published: July 2023

Resumo Este artigo tem como objetivo analisar como professores de Estágio Supervisionado Obrigatório (ESO) do curso de licenciatura em Ciências Biológicas de uma universidade pública foram se constituindo professores de estágio mediante suas histórias de vida. Para tanto, investigou-se a trajetória e/ou atuação dos professores durante a pandemia. Participaram da pesquisa duas professoras de Estágio e, junto a elas, foram realizadas entrevistas, de forma on-line, pela plataforma Google Meet, em dias e horários pré-agendados. Com o fim dessa etapa, realizaram-se as transcrições dos áudios e a análise dos dados, fundamentada na análise de conteúdo. As análises proporcionaram duas unidades de registro: o Período Letivo Excepcional (PLE) e as aulas dos estágios. Os dados permitiram inferir, dentre outros aspectos, que a universidade, as escolas campo de estágio e as professoras do ESO foram obrigadas a se reinventar com aulas síncronas e assíncronas, muitas vezes sem condições adequadas de infraestrutura.
Construção de um medidor de campo magnético para utilização em processos de geração e manipulação de correntes puras de spin
Authors: Silva Wenderson R.F. , Freitas Leonardo V. , Cunha Rafael O.R.R. , Mendes Joaquim B.S.
Published: July 2023

Neste trabalho apresentamos a construção de um medidor de campo magnético (gaussímetro) com alta sensibilidade e detecção de 1 a 80 mT, constituído de componentes eletrônicos simples, com proposta de aplicação em uma montagem experimental para geração de correntes puras de spin por meio do efeito spin Seebeck. Através de um cabo USB, o dispositivo é alimentado e troca dados com um computador via comunicação em linguagem C + + com o Arduino Uno, em conjunto com uma interface gráfica LabVIEW. Para realizar medidas em ambientes de profundidade, como no interior de eletroímãs, desenvolveu-se uma sonda Hall. O equipamento também dispõe de uma tela LCD. O sensor de campo magnético utilizado é o SS49E, com o qual foi possível obter medidas com resolução e alcance apropriadas. O gaussímetro foi empregado no desenvolvimento de uma montagem experimental para investigações dos efeitos spin Seebeck e spin Hall, onde estimamos o ângulo Hall de spin para bicamadas formada por um filme de platina (Pt) crescido sobre um filme magnético isolante de YIG. Portanto, o gaussímetro desenvolvido tem potencial para ser utilizado tanto em ambientes de ensino como os de pesquisa e tem como principal vantagem o baixo custo de produção, de aproximadamente 22 dólares.
Saúde da Família, territórios quilombolas e a defesa da vida
Authors: Alves Hayda Josiane , Soares Maria Raimunda Penha , Costa Rute Ramos da Silva , Santos Letícia de Assis
Published: July 2023

Resumo Este artigo apresenta e discute elementos históricos de luta e resistência quilombolas, aspectos significativos para a produção de saúde e defesa da vida nesses territórios. Articula e tece reflexões sobre a importância e os limites da Estratégia Saúde da Família no reconhecimento, na valorização e na integração de saberes e práticas de comunidades quilombolas ao cuidado profissional em saúde com foco em seus processos de trabalho. Trata-se dos resultados de uma pesquisa-ação participativa em saúde desenvolvida com trabalhadores de uma unidade de Saúde da Família em uma comunidade quilombola no norte do Rio de Janeiro no período da pandemia da Covid-19. Concluiu-se com a pesquisa que, apesar das potencialidades da Estratégia Saúde da Família, os desafios para a integralidade da atenção à saúde no território estudado tendem a comprometer o protagonismo da comunidade - especialmente das mulheres - e a efetividade do cuidado. Não são valorizados, no âmbito da Estratégia, saberes, experiências e memórias ancestrais de cuidado do quilombo - aspectos com pouco rebatimento na atenção territorializada da saúde e, por conseguinte, distantes de uma política pública de direitos.
Fluoride in Mozambique: retrospective study
Authors: DOMINGOS Marta Artemísia Abel Mapengo , SALES PERES Sílvia Helena de Carvalho
Published: July 2023

ABSTRACT Objective: The study aims to analyse the fluoride concentration in the water supply of the capital of each province of Mozambique, 2019 and compare with previous data 1978 and 2008. Methods: The water supply in cities of Mozambique were analysed in 1978, 2008 and 2019 and water from Tete’s River in 1978 and 2019. The fluoride concentration of the water samples was determined in duplicate, using the ion-sensitive electrode (Orion 9609), coupled to a potentiometer (Procyon, model 720), adopting a significance level of 5%. Results: The average fluoride concentration found in the years 1978, 2008 and 2019 was 0.31, 0.33 and 0.14 mg F/L, respectively. The fluoride concentrations collected from household taps in 1978, 2008 and 2019 were: Cabo Delgado/Pemba (0.62, 0.28 and 0.07 mg F/L), Niassa/Lichinga (0.18, 0.98 and 0.07 mg F/L), Nampula/Nampula (0.18, 0.01 and 0.06 mg F/L), Zambézia/Quelimane (0.81, 0.37 and 0.15 mg F/L), Tete/Tete (1.00, 0.97 and 0 .46 mg F/L), Sofala/Beira (0.00, 0.01 and 0.10mg F/L), Manica/Chimoio (0.04, 0.01 and 0.07 mg F/L), Inhambane/Inhambane (0.00, 0.05 and 0.19 mg F/L), Gaza/Xai-Xai (0.01, 0.06 and 0.06 mg F/L) and Maputo (0.23, 0.36 and 0.23 mg F/L), respectively. In the waters of the Zambeze River was 5.5 mg F/L in 1978 and 0.12 mg F/L in 2019. There was no significant change between the fluoride concentrations in the water collected from the taps during the periods studied (p=0.83), however there was a significant difference in the water collected from the river (p<0.05). Conclusion: Tete’ River showed a significant reduction in fluoride concentration, and in the piped water collected in all municipalities, the fluoride content was below optimum.
Telas na Infância: Postagens de Especialistas em Grupos de Cuidadores no Facebook
Authors: Puccinelli Mariana Farias , Marques Fernanda Martins , Lopes Rita de Cássia Sobreira
Published: July 2023

Resumo Apesar das crescentes investigações sobre uso de telas na infância, essa é uma temática complexa e ainda recente, que traz diversos desafios para pesquisadores e cuidadores. Comunidades virtuais em redes sociais são utilizadas por mães e pais para esclarecer dúvidas e receber conselhos acerca da parentalidade e saúde infantil, podendo, simultaneamente, assumir uma função prescritiva e normativa quanto ao seu modo de agir. Sendo assim, este artigo pretende compreender como o uso de telas na infância vem sendo abordado por especialistas em grupos de mães e pais no Facebook. Foi realizado um estudo qualitativo envolvendo 49 postagens de especialistas, sobretudo psicólogos e educadores, extraídas de cinco grupos públicos de mães e pais nessa rede social. Os textos das publicações foram verificados por meio de análise temática e discutidos com base no referencial teórico psicanalítico. Os resultados mostraram que os especialistas destacam os possíveis prejuízos do uso de telas na infância, além de fornecer orientações aos pais sobre como lidar com sua presença no cotidiano das crianças e de suas famílias. Concluiu-se que apesar dos grupos de cuidadores no Facebook serem uma ferramenta de divulgação de informações acerca do uso de telas na infância, cabe não naturalizar a presença de especialistas nesses espaços virtuais criados por pais e mães, interpondo-se nos saberes e nas trocas horizontalizadas entre os cuidadores.
Percepções de acadêmicos e equipe de enfermagem sobre o projeto de extensão: “Caminhando pelo hospital”
Authors: Rosa Yasmin Lorenz da , Boni Fernanda Guarilha , Leite Renata Meirelles , Cunha Jéssica Rosa Thiesen , Echer Isabel Cristina
Published: July 2023

RESUMO Objetivo: Conhecer a percepção de acadêmicos(as) e equipe de enfermagem sobre o projeto de extensão “Caminhando pelo hospital”. Método: Estudo qualitativo realizado em hospital universitário brasileiro de novembro/2019 a abril/2022 com acadêmicos e profissionais de enfermagem participantes de um projeto de extensão universitária. Os dados foram coletados por meio de instrumentos na plataforma Google Forms® e submetidos à Análise da Temática de Conteúdo. Projeto aprovado pelo Comitê de Ética. Resultados: Participaram do estudo 15 acadêmicos, quatro enfermeiros e seis técnicos de enfermagem. Da análise, emergiram quatro categorias: “Conhecendo o ambiente/dinâmica hospitalar”, “Articulação entre teoria e prática”, “Vínculo entre acadêmicos e profissionais da saúde” e “Processo de trabalho da unidade”. Considerações finais: Os achados evidenciam a importância da extensão universitária ao proporcionar conhecimentos e experiências da prática clínica hospitalar, o que pode contribuir no fortalecimento do ensino e da formação acadêmica em enfermagem.
Apoio matricial na atenção especializada respaldado no modelo de atenção às condições crônicas: pesquisa avaliativa
Authors: Marques Francielle Renata Danielli Martins , Pires Grazieli Adrieli Rodrigues , Baldissera Vanessa Denardi Antoniassi , Paiano Marcelle , Carreira Lígia , Salci Maria Aparecida
Published: July 2023

RESUMO Objetivo: Analisar o apoio matricial para equipes de saúde na Atenção Ambulatorial Especializada, segundo o Modelo de Atenção às Condições Crônicas. Método: Pesquisa avaliativa qualitativa, conduzida pelo Modelo de Atenção às Condições Crônicas, realizada de fevereiro a julho de 2020. Para coleta de dados, foram feitas entrevistas com 21 profissionais de saúde, observação da assistência e análise documental do serviço. Os dados foram analisados pela triangulação de dados, com auxílio do software MAXQDA, respeitando todos os aspectos éticos. Resultados: O matriciamento proporcionou aproximação entre Atenção Primária e Secundária; implantou a gestão de casos e qualificou a integralidade da assistência às pessoas com condições crônicas. Fragilidades na comunicação e na compreensão das bases teóricas do apoio matricial foram obstáculos para a adequada implementação das estratégias matriciais. Considerações finais: O apoio matricial para as equipes de saúde especializadas qualificou a atenção profissional dispensada às pessoas com condições crônicas atendidas no serviço.
Intervención educativa de enfermería en mujeres histerectomizadas: protocolo de estudio de método mixto
Authors: Izurieta María Indira López , Molina Alide Alejandrina Salazar , -Barboza Vivian Vílchez , Saez-Carrillo Katia Lorena
Published: July 2023

RESUMEN Objetivos: Conocer el significado de la educación en periodo perioperatorio, en mujeres sometidas a histerectomía por causa benigna y determinar eficacia de intervención educativa de enfermería en mejoramiento de la función sexual femenina, calidad de vida y autoestima en mujeres sometidas a histerectomía por causa benigna. Métodos: Diseño mixto, exploratorio secuencial. Fase cualitativa entrevistas semiestructuradas y análisis de contenido. Fase cuantitativa estudio cuasi experimental, grupo control no equivalente.26 mujeres en 2 grupos. Instrumentos: Biosociodemográfico, Índice de Función Sexual Femenina, Cuestionario SF-36, Escala de Rosenberg. Ambos grupos recibirán atención tradicional y grupo experimental recibirá intervención educativa de enfermería con apoyo de página web. Serán considerados requisitos éticos. Resultados esperados: Las mujeres del grupo experimental mejoraran su función sexual, calidad de vida relacionada con salud y autoestima en relación al grupo comparación. Conclusiones: La educación en periodo perioperatorio de histerectomía es básica para la recuperación de las mujeres que viven esta experiencia.
Children and adolescents living with HIV: participatory health care proposal
Authors: Kinalski Daniela Dal Forno , Antunes Bibiana Sales , Motta Maria da Graça Corso da
Published: July 2023

ABSTRACT Objective: To present a proposal for participatory health care based on the Human Rights of children and adolescents living with HIV. Method: Qualitative study with participatory approach that used the Sensitive Creative Method. The participants were 16 health professionals from three Specialized Care Services in southern Brazil. Data were submitted to Discourse Analysis in the French current. Results: The first thematic category highlighted the perspectives on the right to participation as a new meaning in the science of care. The second category revealed the construction of a participatory care proposal by health professionals, that can be implemented in the daily practice of teamsin six moments. Final considerations: The implementation has the potential to promote the legitimacy of the right to participation and, consequently, the qualification of health care.
Fourth Generation Evaluation as a path for Knowledge Translation in mental health
Authors: Pavani Fabiane Machado , Pires Ananda Ughini Bertoldo , Wetzel Christine , Olschowsky Agnes , Duarte Maria de Lourdes Custódio
Published: July 2023

ABSTRACT Objective: To discuss the use of the Fourth Generation Evaluation methodology as a powerful theoretical-methodological path for the implementation of Knowledge Translation in child and adolescent mental health. Method: It comprises the description of the stages and fieldwork of a research that evaluated mental health practices aimed at adolescents in a Child and Adolescent Psychosocial Care Center, between August and December 2018, with the health care team. Results: Using strategies to involve workers in all stages, a dialectical construction of knowledge, the adaptation of the path to the field - with the implementation of interventions suggested by the participants - and the research path itself, in its condition of product/result, enable the interface with Knowledge Translation. Final considerations: The characteristics discussed allow to suggest using the Evaluation as an alternative to the implementation of Translation, especially in the field of mental health.
Quality of life at work and Burnout in family health strategy workers
Authors: Borges Marta Maria Souza , Nunes Viviane Reis , Pires Mateus Portilho , Lima Bianca Guimarães , Hipólito Ulisses Vilela , Almeida Mirian Cristina dos Santos
Published: July 2023

ABSTRACT Objective: To analyze the correlation between quality of life at work and Burnout in workers in the Family Health Strategy. Methods: Correlational, cross-sectional study carried out with 112 workers, in the pandemic period (October/2020 to June/2021), in Palmas/Tocantins. The Quality of Work Life Assessment Questionnaire (QWLQ-bref) and the Maslach Burnout Inventory - Human Services Survey (MBI-HSS) were used. Results: A strong negative correlation was identified between Emotional Exhaustion and the Physical/Health, Professional and Total Quality of Life Score at work; and moderate negative correlation between Depersonalization and all domains of Quality of Work Life. Professional Achievement showed a moderate positive correlation with the Psychological and Personal domains and with the Total Quality of Work Life Score. Conclusion: The best Quality of Work Life indices were correlated with lower Emotional Exhaustion and Depersonalization scores and higher scores of Professional Achievement.
The representation of touristification in media through mapping: the case of Malaga
Authors: Chamizo-Nieto Francisco José , Salazar Nuria Nebot-Gómez de , Rosa-Jiménez Carlos , Castro-Martínez Andrea
Published: July 2023

Abstract The touristification agenda has had considerable representation in the media in recent years because of tourism specialisation in cities. Existing literature has focused on using content analysis; however, previous content analyses have not typically been mapped. The main objectives were to conduct an in-depth measurement of urban tourism issues covered in the press and the stakeholders involved, but spatially. To show the spatial representation of touristification, Malaga is used as a case study as it is an emerging tourist city. The article analyses the content of 166 news items on touristification in Malaga published in the most-read local newspapers up to and including the year 2020. Data categorised were mapped to assign a sum of news articles about touristification issues at neighbourhood level. Density mapping shows a common pattern for each category: an over-representation of the city centre and a reduction in the number of news items per neighbourhood as we move away from the old town. A Pearson correlation coefficient shows a high spatial correlation between neighbourhoods in the press with several citizen initiatives geolocated on them. A spatial analysis shows where the negative impacts of tourism intensification happen, which may serve as a basis for the local administrations to develop an urban policy to safeguard residential use in those neighbourhoods under tourism pressure. This work serves as a basis for new research on touristification: the addition of case studies to identify common urban patterns and the definition of a social conflict index through the geolocation of the stakeholders involved.
Social Occupational Therapy, pandemic, and interculturalities: thematic workshops in the context of international student mobility
Authors: Andrade Rafaela Ruivo , Galvani Debora
Published: July 2023

Abstract Introduction The Covid-19 pandemic triggered profound changes in people’ ways of life, with significant impact on the forms of socialization and teaching-learning practices. Objective To present the experience of creating and developing intercultural thematic workshops. They were part of a set of welcoming actions and teaching of Portuguese to international students linked to the Student Program of the Graduation Agreement (PEC-G) of Federal University of Sao Paulo (Unifesp), coordinated by teacher of languages—Portuguese as a Foreign Language (PLA)—and social occupational therapy. Method The critical interpretation of the experience, its ordering and reconstruction were guided by the perspective of the systematization of experiences (SE) proposed by Oscar Jara Holliday. The fieldwork involved two perspectives: analysis of field diaries with records of occupational therapy interns between April and October 2020 and a conversation circle with foreign students. Results Four interdependent axes of analysis were thematized, presenting perceptions and reinterpretations of the initial moments of the pandemic and its effects in Brazil, specifically in the contexts of migration and higher education. Conclusion This study provides interdisciplinary, intercultural, and multilingual reflections on social occupational therapy actions in the context of mobility for the purposes of study and internationalization of higher education, as well as analysis technologies developed in times of social distancing and weakening of support networks.