bluuebunny/crossref_metadata_2025 huggingface dataset:
Unlocking the potential of carrot pomace: Enzymatic and impact-disintegrator-activator processing for elevated beta-carotene concentration in carrot powder
Authors: Baskovtceva Angelina , Barakova Nadezhda , Samodelkin Evgeniy , Kiprushkina Elena , Alkhateeb Reem , Tochilnikov Grigory
Published: October 2023

Backgrounds: Carrot pomace is a by-product of the juice industry, which quickly spoils due to its high moisture content and is usually considered waste. However, it is a valuable product containing a significant amount of bioactive compounds, particularly carotenoids.Context and purpose of this study:In this study, we aimed to develop a technology for obtaining carrot powder from carrot pomace with an increased availability of beta-carotene. The unique aspect of the technology involved the use of enzymatic and impact-disintegration-activation processing (IDAP) of the raw material to enhance the release of beta-carotene from plant cells.Objective of this study:To achieve the goal, we have set objectives to compare various dosages of enzyme preparation and to evaluate devices for grinding carrots that can be used to make powder. At all stages, it was necessary to measure the amount of beta-carotene in the samples.Results: It has been found that the yield of carotenoids from carrot pomace is 185% higher compared to whole carrots. Moreover, the application of enzymatic and impact-disintegration-activation processing significantly increases the carotenoid yield in the powder by 17 times compared to carrots (200% in terms of dry matter). This remarkable result was achieved through the described processing method and the selection of the enzyme preparation. Additionally, the mechanoactivation obtained by using the Desi-15 disintegrator played a crucial role. It was also observed that the use of impact-disintegration-activation processing for further grinding of dried carrots can increase the beta-carotene yield by 8 times. Conclusions: The carrot pomace was processed, resulting in a fine-dispersed carrot powder that shows promising applications in the food      or agricultural industries.Keywords: Carrot pomace, beta-carotene, impact-disintegrator-activator processing (IDAP), enzymatic processing, pectolytic enzyme preparations
Deep brain stimulation from past to future: research trends and global outcomes with bibliometric analysis during 1980-2022
Authors: ELİAÇIK Sinan , AYKAÇ Serdar
Published: October 2023

Aims: We aimed to summarize the intellectual structure of the deep brain stimulation (DBS), to reveal the global productivity, to identify and map the latest trends by analysing the social and structural relationships between the different research components of scientific articles published on DBS.

Methods: 5939 articles on DBS published during 1980 and 2022 were analysed utilized various statistical approaches. Network visualization maps were created to reveal trend topics, citation analysis, and international collaborations. Spearman's correlation analysis was used for correlation investigations. The exponential smoothing predictor was used to determine the article productivity trend.

Results: The most prolific author on DBS was Okun, Michael S. (209 articles) and the most productive institution was the University of Toronto (n=283). The top 3 productive countries were United States of America (n=2371, 39.9%), Germany (910, 15.3%), and United Kingdom (550, 9.2%). From past to present, the most studied topics were Parkinson's disease, subthalamic nucleus DBS, dystonia, globus pallidus, essential tremor, movement disorders, thalamus, functional neurosurgery, neuromodulation, depression, obsessive compulsive disorder, basal ganglia.

Conclusion: The primary trend topics that have been studied more in recent years are tractography, freezing of gait, Parkinson’s disease, Parkinson’, Parkinson#apos, autonomy, self, machine learning, non-motor symptoms, functional connectivity, globus pallidus interna, volume of tissue activated, adaptive deep brain stimulation, beta oscillations, medial forebrain bundle, and local field potential. The secondery trend topics were optogenetics, pediatric, frameless, closed-loop DBS, refractory epilepsy, satellite broadcasting, asleep DBS, optimization, biomarker, directional Leeds, nucleus bassals of meynert, personality, authenticity, and anterior nucleus of thalamus.
Prevalence of adrenal incidentaloma in patients performed thorax computed tomography for suspected COVID-19 infection
Authors: AKHANLI Pınar , HEPŞEN Sema , KAYHAN Sanem , DOĞAN Özlem , DÜZKÖPRÜ Yakup , ÇAKAL Erman
Published: October 2023

Aims: The primary purpose of this study is to make a retrospective evaluation of adrenal incidentaloma (AI) prevalence in patients performed thorax computed tomography (TCT), along with determining whether the diagnosed AIs were assessed functionally for adrenal gland hyperfunction and to detect the rate of hyperfunctional AI.

Methods: The patients who applied to with the suspected COVID-19 and performed TCT between January 2020 and December 2021, were included in the present study. However, the patients who were followed-up due to a known adrenal mass and a malignant tumor were excluded.

Results: TCT imaging, including adrenal glands, was performed on 2580 patients. The mean age for these patients was 54±16.8. However, when the patients were separated into groups in terms of adrenal pathology (AP), the mean age for the patients with and without AP was 61.4±11 and 53.8±16.9, respectively (p
A scientometric analysis and visualization of Pott's disease; 2000-2021
Authors: YILMAZ Selçuk , ALKAN Sevil , ÖNER Süleyman Kaan , DEMİRKIRAN Nihat Demirhan , KUYUBAŞI Numan , ARSLAN Cengiz
Published: October 2023

Aims: Spinal tuberculosis, or Pott's disease, is a bacterial infection of the spine, which is primarily brought on by the bacterium Mycobacterium tuberculosis. In this study, Pott's disease-related research papers from the Web of Science database were examined scientometrically. The study's time frame is between 2000 and 2021. To shed light on the trends and advancements in research on Pott's disease, bibliometric techniques are used in the analysis.

Methods: A literature search on spinal tuberculosis was carried out in November 2022 using the WOS search engine. Using specific retrieval keywords, the search covered the years 2000 through 2021. Titles, document types, publication years, author details, affiliations, keywords, funding sponsors, journal names, abstracts, and citations were examined. The data was further processed for both quantitative and qualitative analysis using VOSviewer (1.6.18).

Results: A total of 892 papers from 2000 to 2021 were examined based on search parameters. 430 of these were released as Open Access articles. 81.0% of them were in the Science Citation Index Expanded. The publications came from 77 different nations, China dominated research on Pott's disease with 306 papers, followed by India with 147 and the United States with 86. The investigation revealed a rising trend in recent years, pointing to a rise in interest in Pott's disease. Research fields like neurology and orthopedics made important advances. Notably, 7.7% of the research' funding for Pott's disease publications came from the Chinese National Natural Science Foundation. The leading publishing journal has become the European Spine Journal.

Conclusion: The data shows that China has played a significant role in Pott's disease research, followed by India and the United States. The survey also reveals a growing need for PD research, notably in the disciplines of orthopedics and neurology.
The transition from gel separatory serum tubes to lithium heparin gel tubes in the clinical laboratory
Authors: ZENGİ Oğuzhan
Published: October 2023

Aims: To assess the viability of replacing serum samples with plasma samples in various clinical chemistry and immunoassay tests and to examine the implications of turnaround time (TAT) and sample quality during the transition process.

Methods: We compared the results of 27 paired clinical chemistry and 13 immunoassay tests from samples obtained using gel separator serum and gel separator lithium heparinized plasma (LIH) tubes. We used regression analysis, bias values, and Bland-Altman plots to compare the performance of serum and LIH tubes in various clinical chemistry and immunoassay tests. We collected and evaluated sample aspiration errors, hemolysis index values, and TAT data from the laboratory information system before and after switching to plasma in our study.

Results: Most tests showed no significant difference between the serum and LIH. However, for some analytes, total error (TE) values exceeded the total allowable error (TEa) limits derived from the biological variation database. Notably, insulin TE value did not exceed TEa, but it consumed near all its error budget. Consequently, we determined the alternative allowable error limits for some tests and found that plasma tubes could be used instead of serum tubes for most tests, except for lactate dehydrogenase (LDH). Plasma tubes improved the sample quality, reduced the incidence of aspiration errors, and decreased TAT in the emergency laboratory. We observed significant reductions in TAT after switching to plasma tubes.

Conclusion: Our study showed that LIH tubes can replace serum tubes in most clinical chemistry and immunoassay tests. Using LIH tubes in clinical laboratories can improve healthcare quality and reduce the workload of the laboratory staff.
Does ramelteon have an ameliorative effect in MTX-induced testicular injury?
Authors: ULUSOY KARATOPUK Dilek , ATASOY Nureddin , KUMBUL DOĞUÇ Duygu
Published: October 2023

Aims: The aim of this study was to investigate the potential protective effect of Ramelteon (RMT), which exhibits antioxidant, anti-inflammatory and antiapoptotic properties, against testicular damage induced by Methotrexate (MTX), which is widely used in the treatment of various diseases, including chemotherapy.

Methods: 32 Wistar albino rats were equally divided into four groups: Control (group I), MTX (group II), MTX+RMT (group III) and RMT (group IV). Histologic evaluation was performed using Hematoxylin and Eosin (H&E) staining, immunohistochemical analysis using TNF-alpha and Cas-3, and biochemical evaluation using TAS, TOS and OSI.

Results: Histologic analysis using H&E staining revealed a significant difference between group I and groups II and III (p0.05). While normal histologic structures were observed in groups I and IV, histopathologic findings were noted in groups II and III. Immunohistochemical evaluation of TNF-alpha and Cas-3 showed a significant difference between group I and groups II and III (p0.05). The highest immunostaining intensity was observed in group II. Biochemical evaluation revealed statistically significant differences in TAS, TOS and OSI parameters reflecting oxidative stress differences between the groups (p
Evaluation of the relationship between mitral annular calcification and triglyceride-glucose index
Authors: GÖKALP Gökhan , ÖZBEYAZ Nail Burak , ÖZİLHAN Murat Oguz
Published: October 2023

Aims: Mitral annular calcification (MAC) is an echocardiographic condition with a multicomponent etiopathogenesis, one of which is insulin resistance. Triglyceride-glucose (TyG) index is an excellent biochemical parameter that has proven itself in determining insulin resistance in recent years. This study aims to reveal the relationship between the TyG index and the presence of MAC.

Methods: The study included 159 patients with MAC and 167 control group. The control group has similar demographic characteristics such as age, gender, presence of hypertension (HT), and diabetes mellitus with the MAC group. TyG index was calculated as a formula: ln[fasting triglyceride (mg/dl) × fasting plasma glucose (mg/dl)/2].

Results: The mean age of the patients was 74.2 and 48.2% of the patients were male. Coronary artery disease (CAD) (p: 0.031), glucose (p:0.001), total cholesterol (p:0.009), low-density lipoprotein (LDL) (p:0.004), triglyceride (TG) (p
Applying Generative Models and Transfer Learning to Physiological Data Classification
Authors: Núñez José Fernando , Arjona Jamie , Tormos Adrián , García Darío , Béjar Javier
Published: October 2023

The scarcity and imbalance of datasets for training deep learning models in a specific task is a common problem. This is especially true in the physiological domain where many applications use complex data collection processes and protocols, and it is difficult to gather a significant number of subjects. In this paper, we evaluate generative deep learning algorithms by training them to create data based on open physiological datasets and conduct a study on their potential for transfer learning. We measure the performance change of classifiers when the training data is augmented with the synthetic samples and also perform experiments in which we fine-tune classification models trained with the generated data adding increasing amounts of the real data to investigate the transfer learning capabilities of synthetic datasets. Finally, we advise and provide the best option for researchers interested in augmenting ECG datasets using these algorithms and the best fine-tuning strategies that would generalize correctly when tested on new data from the same domain but for a different classification task.
Navigating Black Swan Events in Algorithmic Trading: A Reinforcement Learning Perspective
Authors: Villamarín Díaz Fernando , Guerrero-Mosquera Carlos
Published: October 2023

This study evaluates Reinforcement Learning (RL) techniques for financial trading during unpredictable market conditions, such as black swan events. Three experiments were conducted: one where the algorithms were trained and tested over the same period; another where they were trained and tested over different periods; and the final one where they were trained over a certain period and then tested during a period that included a black swan event (the market crash of March 2020). Results show that RL methods outperform traditional strategies in the in-sample period, but struggle to adapt during the black swan event. The results show the potential of RL techniques in financial trading with the right approach.
Capturing Young People’s Interest in Food Waste Reduction: An Approach Using Qualitative Reasoning
Authors: Zacharaki Konstantina , Nguyen Jennifer , Prat-I-Pubill Queralt , Agell Núria
Published: October 2023

According to the United Nations Food and Agriculture Organization (FAO) more than one third of the food produced globally is lost or wasted. This tremendous amount of food waste highlights the urgent need to investigate this phenomenon promptly with powerful methods in order to reduce it. In the present work, we consider a qualitative reasoning approach in an attempt to understand people’s interest in the food waste (FW) problem. To do so, we have run an in-person taste experiment and have acquired data from 188 participants. We apply a measure based on a cosine similarity to capture the degree of interest towards the environment as individuals respond to the New Environmental Paradigm scale (NEP). Previously, they had to decide on whether a piece of fruit allegedly coming from the supermarket is better than another one allegedly coming from an alternative source such as applications designed to reduce food waste. We are using the taste experiment and the questions as a base to gain a more in-depth understanding of the drivers behind FW.
Involving Patients into the LifeChamps Project: Preliminary Findings
Authors: Kokoroskos Emmanouil , Stathakarou Natalia , Rauhala Erica , Mantziari Despoina , Baxevanis George , Papachristou Nikolaos , Bilis Antonis , Bamidis Panagiotis , Papachristou Panagiotis
Published: October 2023

Patient involvement in research has been highlighted as a major requirement for the development of products and services that cover actual patients’ needs. However, there has not been an agreement on a commonly used standard for patient involvement in research, at least not in the EU, partially because of lack of common terminology and implementation methodology. Within the standardization activities of “LifeChamps: A Collective Intelligent Platform To Support Cancer Champions”, this qualitative study was developed to discover patients’ views for their engagement in research. This is an ongoing qualitative study of semi-structured interviews of cancer survivors aged over 65 years of age, exiting the feasibility studies of the LifeChamps project in Stockholm and Thessaloniki. Findings from the thematic analysis of this study are expected to indicate requirements for involvement of patients in research studies as participants.
Planning for a Crisis: Predicting Anxiety in a Population During COVID-19 Using Machine Learning
Authors: Kumari Bhawna , Goyal Nidhi , Elmorr Christo
Published: October 2023

COVID-19 impact on population mental health has been reported around the world. Statistics Canada has conducted a survey among Canadian population to gauge mental health challenges they experienced, specifically in terms of anxiety. We create a machine learning model to predict anxiety symptoms as measured by the General Anxiety Scale among the sample of 45,989 respondents to the survey. Eight algorithms including Logistic Regression, Random Forest, Naive Bayes, K Nearest Neighbours, Adaptive boost, Multi linear perceptron, XGBoost and LightBoost. LightBoost provided the highest performing model AUC score (AUC=87.45%). In addition, the features “perception of mental health compared to before physical distancing”, “perceived life stress”, and “perceived mental health” were found to be the most important three features to predict anxiety. A limitation of this study is that the sample is not representative of the Canadian population. Preparing for virtual care interventions during a crisis need to take into considerations these factors.
Challenges in Early Diagnosis of Melanoma Using Tele-Dermatology
Authors: Gudiu Adela-Vasilica , Stoicu-Tivadar Lacramioara
Published: October 2023

Numerous classification systems have been developed over the years, systems which not only provide assistance to dermatologists, but also enable individuals, especially those living in areas with low medical access, to get a diagnosis. In this paper, a Machine Learning model, which performs a binary classification, and, which for the remainder of this paper will be abbreviated as ML model, is trained and tested, so as to evaluate its effectiveness in giving the right diagnosis, as well as to point out the limitations of the given method, which include, but are not limited to, the quality of smartphone images, and the lack of FAIR image datasets for model training. The results indicate that there are many measures to be taken and improvements to be made, if such a system were to become a reliable tool in real-life circumstances.
Robotic Process Automation Based Data Extraction from Handwritten Medical Forms
Authors: Gal-Nadasan Norbert , Stoicu-Tivadar Vasile , Gal-Nadasan Emanuela , Dinu Anca Raluca
Published: October 2023

This paper proposes to create an RPA(robotic process automation) based software robot that can digitalize and extract data from handwritten medical forms. The RPA robot uses a taxonomy that is specific for the medical form and associates the extracted data with the taxonomy. This is accomplished using UiPath studio to create the robot, Google Cloud Vision OCR(optical character recognition) to create the DOM (digital object model) file and UiPath machine learning (ML) API to extract the data from the medical form. Due to the fact that the medical form is in a non-standard format a data extraction template had to be applied. After the extraction process the data can be saved into databases or into a spreadsheets.
Roadmap for Aligning Cardiovascular Digital Health in Austria with the European Health Data Space (EHDS) Ecosystem
Authors: Hussein Rada , Sareban Mahdi , Treff Gunnar , Niebauer Josef
Published: October 2023

Translating the proposed European Health Data Space (EHDS) regulations and requirements into reality is a challenging task. In this work, we provide a roadmap for aligning the EHDS requirement into the cardiovascular (CV) digital health domain in Austria. To achieve that, we first examined the current eHealth infrastructure and initiatives in Austria. Then, we created a CV-connected health model and addressed the challenges facing cardiac telerehabilitation in Austria. Finally, we mapped the European CV strategies to the Austrian context for EHDS implementation. Accordingly, we were able to provide an Enterprise Architecture (EA) framework for aligning CV digital health with the Austrian EHDS context. The created EA model can be also used as a guiding framework for aligning other medical domains in Austria with EHDS.
International Clinical Research Data Ecosystem: From Data Standardization to Federated Analysis
Authors: Rinaldi Eugenia , Dellacasa Chiara , Puskaric Miroslav , Osmo Thomas , Gorska Anna , Stellmach Caroline
Published: October 2023

Within the HORIZON 2020 project ORCHESTRA, patient data from numerous clinical studies in Europe related to COVID-19 were harmonized to create new knowledge on the disease. In this article, we describe the ecosystem that was established for the management of data collected and contributed by project partners. Study protocols elements were mapped to interoperability standards to establish a common terminology. That served as the basis of identifying common concepts used across several studies. Harmonized data were used to perform analysis directly on a central database and also through federated analysis when data was not permitted to leave the local server(s). This ecosystem facilitates the answering of research questions and generation of new knowledge available for the scientific community.
The Patient’s Own Health Data Repository and Discharge Letters
Authors: Meijer Wouter
Published: October 2023

Discharge letters could be sent to the patients. This poster explores pros and cons of such a procedure.
Patients’ Experiences of Initiating Video Consultations
Authors: Muli Irene , Davoody Nadia , Taloyan Marina , Hvitfeldt Helena , Jäderlund Hagstedt Lovisa , Hägglund Maria
Published: October 2023

Implementation and adoption of video consultations (VCs) in healthcare are not straightforward. Experiences of initiating a VC could increase our understanding of adoption by patients. This study aims to report patients’ experiences of installing and booking a VC in primary care. Most people found it easy to find and install the VC application. Those with a higher self-reported ability and habit of using digital services and the internet found it easier than those reporting lower ability and habit. About half of our respondents had booked their recent VC themselves, most of whom had done so through a telephone call or the application “Alltid Öppet”. The booking process was perceived to be easy by most but more difficult compared to installation. The easy installation process might have led to higher adoption by older people. Nevertheless, during implementation more support should be provided to people with lower digital service and internet use abilities and habits as they might find VC set-up more difficult. More attention should be given to the booking process as it may be a barrier potentially influencing adoption.
Subjective Cognitive Load Evaluation of a Mobile Personal Health Record Application
Authors: Zayim Neşe , Yildiz Hasibe , Yüce Yılmaz Kemal
Published: October 2023

Mobile Personal Health Records (mPHRs), which make it possible to track and manage users’ health information, can be an important aid in improving people’s health. Despite its potential benefits, poor usability of systems can hinder the adoption and use of mPHRs. This study aims to evaluate the usability of a mobile health application in terms of perceived cognitive workload and performance. The cognitive workload experienced by 30 volunteers (15 experienced and 15 inexperienced), was measured while performing the given tasks with the NASA-Task Load Index (NASA-RTLX) scale, and the duration of the fulfillment of the tasks by eye tracking device. While there was no significant difference between the two user groups in the completion time of the tasks, a significant difference was found in the perceived cognitive load. “Making an appointment”, which could take much longer to complete than other tasks, resulted in the highest cognitive load for all users. Further usability research using think-aloud protocols and user interviews could provide insights into design improvements for reducing cognitive load and enhancing performance.
Age-Specific Diagnostic Classification of ASD Using Deep Learning Approaches
Authors: Jain Vaibhav , Singh Sengar Sandeep , Agastinose Ronickom Jac Fredo
Published: October 2023

Autism Spectrum Disorder (ASD) is a highly heterogeneous condition, due to high variance in its etiology, comorbidity, pathogenesis, severity, genetics, and brain functional connectivity (FC). This makes it devoid of any robust universal biomarker. This study aims to analyze the role of age and multivariate patterns in brain FC and their accountability in diagnosing ASD by deep learning algorithms. We utilized functional magnetic resonance imaging data of three age groups (6 to 11, 11 to 18, and 6 to 18 years), available with public databases ABIDE-I and ABIDE-II, to discriminate between ASD and typically developing. The blood-oxygen-level dependent time series were extracted using the Gordon’s, Harvard Oxford and Diedrichsen’s atlases, over 236 regions of interest, as 236x236 sized FC matrices for each participant, with Pearson correlations. The feature sets, in the form of FC heat maps were computed with respect to each age group and were fed to a convolutional neural network, such as MobileNetV2 and DenseNet201 to build age-specific diagnostic models. The results revealed that DenseNet201 was able to adapt and extract better features from the heat maps, and hence returned better accuracy scores. The age-specific dataset, with participants of ages 6 to 11 years, performed best, followed by 11 to 18 years and 6 to 18 years, with accuracy scores of 72.19%, 71.88%, and 69.74% respectively, when tested using the DenseNet201. Our results suggest that age-specific diagnostic models are able to counter heterogeneity present in ASD, and that enables better discrimination.
Real-Time Detection of Emotions Based on Facial Expression for Mental Health
Authors: Turcian Darius , Stoicu-Tivadar Vasile
Published: October 2023

When it comes to health, a very widespread problem nowadays is mental health, where almost 18% of the world’s population suffers from certain mental illnesses. Artificial intelligence (AI) is a concept that evolves strongly and is expected in the near future to bring improvements and help to humans in various fields. The field of mental health is not excluded, so AI can help in the performance of medical services, either by helping the medical staff or patients. In terms of mental health, it has been observed that by recognizing facial expressions, depression, schizophrenia, or other similar conditions can be detected. However, for automatic learning, a very large data set is required for good accuracy. In this paper, we present a facial expression recognition method using only a few training data, which could be used remotely through a mobile or web application.
Exploring the Operational and Technical Changes in the Healthcare Sector During the COVID-19 Pandemic
Authors: Muzaik Suhail , Davoody Nadia
Published: October 2023

The COVID-19 pandemic has affected the healthcare sector globally including Sweden, creating subsequent operational and technical changes to the wide range of digital healthcare services utilized by healthcare professionals or end consumers. A qualitative study using a self-assessment survey based on the national health services digital maturity assessment was used to study these changes from the perspective of personnel working in Swedish healthcare-related organizations. The number of 30 respondents was selected using purposive sampling, out of them 11 responded. The study highlighted positively perceived changes such as boosting digitalization, improving the procurement process, and introducing crisis management teams. Improving the offered digital services, the tools’ effectiveness, efficiency, and technical support were also some of the results. On the contrary, the negatively perceived changes were limiting access to the services, limiting technical support, and reprioritizing non-essential services and projects.
Digital Health and Health Promotion: A Scoping Review of Systematic Reviews
Authors: Margariti Artemis , Stathopoulou Agathi , Koulouvari Areti-Dimitra , Sakellari Evanthia , Lagiou Areti
Published: October 2023

Introduction and Methodology: Health Promotion is moving into a new technological era, that of Digital Health Promotion (DHP). The aim was to collect systematic reviews of digital health promotion interventions. Results and Discussion: 147 articles met the criteria and were included in the present study. A diverse range of digital health promotion topics was identified, with certain topics garnering significant attention. While this scoping review provides valuable insights into the field of digital health promotion interventions, a more detailed analysis of their alignment with health prevention stages will serve as a critical next step.
Panax ginseng C.A. Mey. as a potential raw material in the treatment of negative effects of alcohol consumption
Authors: Kompała Monika , Kuc Julia , Skotnicki Zbigniew , Jasińska-Balwierz Agata , Hudz Nataliia , Balwierz Radosław Jerzy , Lipok Jacek
Published: October 2023

An alcohol hangover is a complex set of adverse symptoms that occur after excessive consumption of alcoholic beverages. Hangovers are not solely caused by ethanol, but mainly by its toxic metabolites, such as acetaldehyde and acetic acid. Most of the negative symptoms occur when the concentration of alcohol in the blood decreases after drinking. Given that a large percentage of people consume alcohol and experience negative effects from its consumption, potential supplementation to help eliminate these adverse effects has been proposed. One promising ingredient is ginseng, which has been used in Eastern culture and traditional Chinese medicine for over 2,000 years. The aim of this study was to present the potential of Panax ginseng C.A. Mey. as an aid for the adverse effects of alcohol consumption and its protective effect on liver function. The literature analysis was based on data indexed in medical databases PubMed, Scopus, and Medline since 2010, using keywords such as "Panax ginseng," "hangover," "alcohol consumption," and "metabolism," connected by the logical conjuction “and.” The analysis confirmed the effectiveness of P. ginseng in the treatment and prevention of hangovers. Preparations containing P. ginseng can support ethanol metabolism by inducing enzymes such as alcohol dehydrogenase, aldehyde dehydrogenase, and the cytochrome P450 isoform 2E1 system. An additional advantage of using P. ginseng may be its hepatoprotective effect.
Insulin resistance and iatrogenic hyperinsulinemia in type 1 diabetes - norm or complication? Role of metformin in type 1 diabetes mellitus
Authors: Bekier Małgorzata , Uruska Aleksandra , Szkutnik-Fiedler Danuta
Published: October 2023

There is a rising trend of overweight and obesity among individuals with type 1 diabetes. This is often associated with decreased insulin sensitivity, increased insulin dose requirements and poor glycemic control. Insulin resistance is a state of diminished effect of insulin on target tissues, despite normal or elevated serum insulin levels. Metformin as an adjunct to insulin in treating overweight or also not specific image of insulin resistance (without overweight or hormonal disorders) adults with type 1 diabetes is increasingly used. The main goal of this off-label type 1 diabetes treatment method is to improve insulin signaling leading to a subsequent increase in glucose uptake by skeletal myocytes, inhibition of hepatic gluconeogenesis and, as a result, a reduction in the need for a daily dose of insulin. The use of metformin as an addition to insulin may increase the chance of achieving target glucose control and reduce the anabolic effect of this hormone. Metformin can improve insulin sensitivity, glycemia and modulate cardiovascular disease risk factors or nonalcoholic fatty liver disease. In the vast majority of clinical trials conducted with metformin in type 1 diabetes, the effect of the drug on daily insulin doses, improvement in lipid parameters, and decline in body fat was assessed without correlating pre-specified outcomes with drug plasma concentrations.
Modern Monads: Leibniz, Continuity, and the Stream of Consciousness
Authors: Edwards Jonathan
Published: October 2023

What is a perceiving ‘me’ or ‘soul’ and does it endure, perhaps for eternity, or is it merely one of a sequence of evanescent events? Conscious perception poses several puzzles in relation to subject identity and continuity that Leibniz paid close attention to. Re-applying Leibniz’s principles in a modern context suggests two conclusions. Firstly, his search for fundamental indivisible (monadic) perceiving dynamic units looks as motivated as ever. Secondly, modern physics may suggest ways to mitigate the temporal paradox raised for Leibniz by Russell, in which events of experience may be both distinct and part of a continuum. Recent condensed matter physics provides a hierarchy in indivisible dynamic units that invites a more subtle application of Leibniz’s ideas on continuity and divisibility. Our experience as a ‘string of mental pearls’ may be peculiar to certain types of fundamental dynamic unit with a ‘constant internal principle of change’ but variable energy content, typified by collective modes of excitation in condensed matter. In simple terms, a local domain of the electromagnetic field may ‘inform’ a collective mode (such as an acoustic mode) both by bringing it into existence and, in addition, through ongoing variation, updating the mode about changing events to which the mode can respond with shifts in energy content. These shifts will divide the mode into individual indivisible excitations - perhaps the best candidates for individual events of experience. Leibniz’s monadic analysis may not escape intact, but his guiding principles may.
Business projects need to be handled differently from construction projects
Authors: Einhorn Frank
Published: October 2023

Any change in how an organisation does things, or in the products that it offers, is a business project. Such projects differ greatly from a pure construction project where something is built according to an approved design. Project management techniques apply to both, but the way in which they are applied is usually very different. Text books and courses tend to cover the techniques but seldom explain which need adaptation for business projects. This paper contrasts a typical construction project with a typical business project. It then shows some of the techniques that need to be applied differently. It also indicates possible areas for future research.
Penetrasi Sosial Pada Pasangan Homoseksual Di Jakarta
Authors: Azhari Robby Nova
Published: October 2023

Masih banyak masyarakat Indonesia yang masih belum bisa menerima adanya kaum homoseksual di dalam kehidupan sosialnya. Karena menurut masyarakat, homoseksual itu dianggap sebuah hal yang menyimpang. Namun, seiring dengan perkembangan zaman, banyak kaum homoseksual yang sudah mulai membuka dirinya ke publik atau masyarakat dengan mengakui bahwa mereka adalah gay. Penelitian ini bertujuan mengetahui bagaimana proses penetrasi sosial yang dilakukan oleh kaum homoseksual di dalam membangun sebuah hubungan yang personal. Penelitian ini menggunakan metode deskriptif kualitatif dengan pendekatan metode penelitian analisis deskriptif. Penelitian ini dilaksanakan di Kota Jakarta. Jenis dan sumber data yang digunakan adalah data primer dan data sekunder. Data primer atau data utama berupa hasil wawancara dengan informan dan data sekunder atau data pendukung berupa buku, jurnal, artikel, dan internet. Informan terdiri atas dua orang atau satu pasangan homoseksual. Data yang dikumpulkan berupa hasil wawancara mendalam dengan informan. Penelitian ini menggunakan dua jenis teori, teori penetrasi sosial dan teori komunikasi antar pribadi. Hasil penelitian ini menunjukkan bahwa komunikasi yang dilakukan antara kaum homoseksual sama seperti komunikasi yang dilakukan oleh masyarakat lainnya di dalam membangun sebuah hubungan. Ada banyak cara yang dilakukan oleh kaum homoseksual di dalam mencari pasangan seperti menggunakan aplikasi kencan.
Child and adolescent anthropometric dynamics in ontogeny of 10–17 age in regional aspect of Magadan
Authors:   Scientific Research Center “Arktika” FEB RAS, Karl Marks Street, 24, Magadan, 685000, Russia, Karandasheva Victoria Olegovna
Published: October 2023

Introduction. Physical development of younger generation is considered to be important part of age biology issues. This research aimed to conduct the assessment study on physical development of modern children and adolescents born and permanently living in extreme conditions of the North-East of Russia, and compare it to the 2001 survey. Materials and methods. Four thousand two hundred and seven schoolchildren aged 10–17, both males and females, participated in the 2019 monitoring. Basic anthropometric parameters were measured for each student: Body Length, Body Mass, Chest Circumference in pause, and Body Mass Index was calculated. We comparatively analyzed the age dynamics of the studied anthropometric indicators and the rate of change in these indicators during the year within each age group, as well as differences between the same age groups of the 2001 and 2019 surveys. Results. Modern adolescents tend to be higher in somatometric indices as compared to those of previous years. Modern boys exhibited higher BM within the age of 13–16 (p<0.05), BL within the age of 11–16 (p<0.05), and CC at the age of 17 (p<0.05). They experience the active increase in their BM, BL, and CC starting at 12–13 while the boys from the 2001 survey demonstrated the comparable increase (p<0.05), they are higher in BM at the age of 12–15 (p<0.05), and CC at ages of 11 and 13–14 (p<0.05). Modern girls show the active increase in their BM, BL, and CC starting at 11–13, while it lasted until the age of 14 in the girls from the 2001 survey. The BMI variables proved to increase towards overweight and obesity: boys gained 2.2 kg and 5.4 kg, and girls 9.5 kg and 5 kg, respectively. Conclusion. We found the shift of the growth leaps in BL, BM, and CC to younger ages as characteristic of the modern adolescents. In general, higher variables of the studied indicators are evidence of the ongoing acceleration processes in physical development. @ 2023. This work is licensed under a CC BY 4.0 license
A Case series of Tinea corporis caused by Microsporum audouinii: sharing is not always caring
Authors: Jangla Sunayana Mukesh
Published: October 2023

Tinea corporis caused by Microsporum audouinii is reported herein from two Indian adult females of age 27 and 33 years who are sisters. The fungus was reported from both based on microscopic and culture findings. Both cases had a satisfactory response to the ketoconazole and tolnaftate combination. Infections by this dermatophyte barring tinea capitis are few and far between and hardly reported. Hence, this is an exquisite case series to be reported in the literature. This report also highlights measures to be taken to prevent the transmission of fungal mold through fomites.
Acute heart failure and cardiogenic arterial thromboembolism in cats: clinical and echocardiographic features
Authors: Petrushko A. S. , Grushanska N. H.
Published: October 2023

Acute heart failure and arterial thromboembolism are common complications of hypertrophic cardiomyopathy in cats. These conditions have many common links in pathogenesis, so analyzing the differences between them improves the understanding of the impact of vessel occlusion on the body. In the study, 40 clinical cases were analyzed and two groups were formed: the first – cats with arterial thromboembolism and the second – cats with acute heart failure. The data from anamnesis, clinical examination and echocardiographic examination were collected. Age, sex, breed, weight, temperature, frequency of respiratory movements, signs of dyspnea, presence of pulmonary edema, presence of free fluid in the chest and pericardial cavities were analyzed. The following echocardiographic parameters were analyzed: left ventricular wall thickness, left ventricular end-systolic and end-diastolic dimensions, diameters of the aorta and left atrium, heart rate and left ventricular contraction fraction.  It was established that the majority of animals from both groups were males. Acute heart failure was registered mainly in young cats (M = 3.7), in contrast to animals with arterial thromboembolism (M = 6.7), (P < 0.01). There was no significant difference in the values of rectal temperature, weight, heart rate, aortic diameter, and left ventricular contraction fraction. Most animals from both groups had signs of dyspnoea. The difference in the frequency of respiratory movements was significant (P < 0.01). In cats with acute heart failure, pulmonary edema was diagnosed in 85%, free fluid in the thoracic and/or pericardial cavities in 55 %. In animals with thromboembolism, edema was found in 45 %, and effusion in the chest and/or pericardial cavities in 30 % of animals. The established differences indicate that arterial thromboembolism develops in animals that have had heart pathology for a longer period of time, whereas acute heart failure occurs more suddenly in cats.
Effect of mineral feed additive on productivity of broiler chickens
Authors: Poberezhets J. M. , Ohorodnichuk G. M. , Razanova O. P. , Gutyj B. V. , Skoromna O. I. , Farionik T. V.
Published: October 2023

Mineral elements play an essential role in the metabolic processes carried out in the animal body at the cellular level. They support homeostasis, acid-base balance, and osmotic pressure. Lack of mineral elements leads to disturbances in metabolic metabolism, reduced productivity, and increased morbidity in poultry. Therefore, the research aimed to establish the effect of selenium-containing feed additives on broiler chickens' live weight, gains, feed consumption, slaughter, and hematological indicators. Selenium – exchanges proteins, fats, and carbohydrates to regulate enzymatic and redox reactions. The introduction of selenium into animals' rations contributes to the normalization of metabolism, preventing the accumulation of toxic oxidation products and damage to the cell membrane. The experiment lasted 42 days. Two groups of Ross-308 cross-broiler chickens, 20 heads each, were selected for the experiment. In addition to compound feed, the second experimental group used a mineral feed additive at the rate of 100 g per 1 ton of compound feed. When broiler chickens were fed a mineral feed additive, live weight increased by 4.9 %, average daily weight gain by 4.8 %, and absolute weight gain by 5.0 %, relative to control counterparts. It was established that using a mineral feed additive in feeding broiler chickens of the 2nd group, the consumption of feed per 1 kg of growth decreased by 9.0 %, compared to control analogs. It was found that the pre-slaughter live weight of broiler chickens of the 2nd group increased by 5.0 %, the weight of non-carcass carcass by 5.6 %, half-carcass by 5.5 %, and carcass weight by 6.2 %, compared to the control value. In addition, under the influence of the studied feed additive, the mass of the pectoral muscles in broilers of the 2nd group increases by 16.0 % (Р ≤ 0.05) and thigh muscles by 36.0 % (Р ≤ 0.001) relative to control indicators. It was found that in the broilers of the 2nd group, under the influence of the additive, the slaughter yield of the thigh muscles increased by 29.4 % (Р ≤ 0.05) compared to the control group. It was established that under the action of the mineral supplement, the level of hemoglobin in broiler chickens of the 2nd group increased by 5.3 % (Р ≤ 0.05) relative to the control value.
Determination of heart rate variability as an indicator of the influence of the tone of the autonomic nervous system in goats
Authors: Boychuk B. I. , Karpovskyi V. I. , Hryshchuk I. A. , Tomchuk V. A. , Hryshchuk A. V. , Gutyj B. V. , Karpovskyi V. V.
Published: October 2023

The relevance of the topic lies in the studied role of the autonomic nervous system in regulating the cardiovascular system in goats. The variability of the heart rate is a good indicator in the study of the animal's health quality and the analysis of its psychophysiological state in the farm. The purpose of the study is to establish the influence of the tone of autonomous nervous regulation on the body of goats, which is reflected in changes in the sympatho-vagal balance. Experimental studies were carried out on goats of the Zaanenska breed. A cardiograph was used to diagnose the variability of the heart rate, followed by the determination of the main indicators according to Baevsky's method, which included the determination of mode, mode amplitude, variation range, autonomic balance index, autonomic rhythm index, and stress index. Based on the results of the study, three research groups were formed: normotonics, vagotonics, and sympathotonics. Sympathotonic animals had high values of heart rate 96.80 ± 6.62, intensity of the R-R interval 35.30 ± 1.18, and low values of the value of the R-R interval 0.63 ± 0.04 (Р ≤ 0.05; Р ≤ 0.001). Vagotonic goats had the opposite features, characterized by a decrease in heart rate 58.4 ± 2.21, the intensity of the R-R interval 12.44 ± 1.11, and an increase in the value of the R-R interval 1.03 ± 0.04 (Р ≤ 0.01; Р ≤ 0.001). Normotonic animals, compared to other experimental groups, had average values. Based on the obtained results, goats, depending on the influence of the tone of the autonomic nervous system, have differences in the activity of the cardiovascular system. Due to this, their response to the stress factor will differ, which in turn will affect productivity. Determination of heart rate variability can become one of the indispensable indicators in the analysis of animal health on dairy farms. Therefore, this question is quite relevant, especially when studying the metabolic processes of the body of goats, to improve the efficiency of productivity while preserving the physiological state of the animal.