bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical research of insulin glargine U300 in type 1 diabetes mellitus patients with frequent hypoglycaemia: real-world experience
Authors: Volkan Kişioğlu Savaş , Suat Demir Ahmet , Tufekci Damla , Emur Gunay Yasemin , Coskun Hulya , Ucuncu Ozge , Nuhoglu Irfan , Kocak Mustafa , Karakullukcu Serdar , Onder Ersoz Halil
Published: April 2021

Introduction

We aimed to see whether insulin glargine U300 can provide better blood glucose control while reducing hypoglycaemia in a more homogeneous population compared to previous studies.

Material and methods

The retrospective study included type 1 diabetes mellitus (T1DM) patients with frequent hypoglycaemia. For evaluation of fasting blood glucose, haemoglobin glycated (HbA1c) and weight at 6 months and 12 months (final), observation windows of 120–240 days (4–8 months) and 240–480 days (9–16 months) after insulin glargine U300 initiation, respectively, were permitted. Mean follow-up time was 12 months. Hypoglycaemia was defined as blood glucose level < 70 mg/dl, either symptomatic or asymptomatic, measured in hospital or at home.

Results

Forty-four patients were included in the study, and 35 patients completed the study – 20 (57.1%) females and 15 (42.9%) males, with a mean age of 24.1 ±6.6 years. Mean body mass index was 24.4 ±7.4 kg/m2. A significant decrease was not found between baseline and HbA1c values at 6 months (p = 0.199), but a significant decrease was found in the final period (between 9–16 months) (p = 0.025). Hypoglycaemic events occurred in all patients (100%) before using insulin glargine U300, while the incidence of hypoglycaemic events gradually decreased to 74.3%, 68.6%, and 68.6% between months 1–3, 3–6, and 6–9, respectively. Of the 26 patients who declared their level of satisfaction, 23 (88.5%) were satisfied, 2 (7.7%) indicated that there was no significant difference, and 1 (3.8%) patient was unsatisfied.

Conclusions

Over 9–16 months of follow-up, insulin glargine U300 led to a significant reduction not only of HbA1c levels but also of the frequency of hypoglycaemia, and also yielded high satisfaction rates.
Aspirin in primary prevention of cardiovascular disease in diabetes
Authors: K. Papazafiropoulou Athanasia , Melidonis Andreas , Antonopoulos Stavros
Published: April 2021

It is well established that people with diabetes are at an increased risk of cardiovascular disease compared with those without diabetes. Although the protective role of aspirin in secondary prevention is well documented, its role in primary prevention of cardiovascular disease in people with diabetes, after the results of major clinical trials and meta-analyses, is unclear. The observed discrepancies might be explained in part in terms of the differences between the background cardiovascular risks, follow-up periods, age and gender of the study populations. Recently, the results of the ASCEND trial in people with diabetes documented the cardiovascular benefit of aspirin for primary prevention, but with an increased risk of bleeding that might outweigh the observed cardiovascular benefit. Therefore, current guidelines recommend its use for primary prevention in people with and without diabetes under specific circumstances. The purpose of the present review is to summarize the existing literature data regarding the place that aspirin has in primary prevention of cardiovascular disease in people with diabetes.
Effect of leptin concentrations and leptin receptor gene polymorphisms on the outcome of renal transplantation
Authors: García-Pino Guadalup , Luna Enrique , Mota-Zamorano Sonia , González Luz María , Tormo María Ángeles , Gervasini Guillermo
Published: April 2021

Introduction

Leptin is a pro-inflammatory adipocytokine implicated in cardiovascular disease, insulin resistance, obesity and chronic kidney disease.

Material and methods

In a cohort of 236 renal transplant recipients, we aimed to determine whether circulating leptin concentrations and/or three polymorphisms in the leptin receptor (LEPR) gene, namely rs1137100, rs1137101 and rs1805094, were related to clinical outcomes in renal transplantation. Plasma leptin concentrations were measured by ELISA. Genetic variants were determined by conventional real-time PCR assays, and statistical associations with clinical outcomes were obtained by logistic regression modelling.

Results

Patients with elevated leptin levels were at higher risk of acute rejection (OR = 1.03 (1.01–1.05), p = 0.03) and displayed worse renal clearance (p = 0.001) than patients with lower levels. Leptin levels were not significantly affected by any of the three LEPR SNPs. The rs1137101 G variant showed an inverse association with the risk of delayed graft function (DGF) (OR = 0.42 (0.22–0.81), p = 0.009), whilst the homozygous rs1805094 CC genotype was associated with increased risk of acute rejection (OR = 11.38 (2.15–60.16), p = 0.004). A statistically significant association was also observed between the rs1137100 GG genotype and better renal function [mean difference vs. AA/AG = 20.20 (4.91–35.49) ml/min, p = 0.010].

Conclusions

Our results show that both leptin plasma concentrations and polymorphisms in the LEPR gene may affect clinical outcomes in renal transplant recipients, suggesting that the determination of these parameters could be useful in predicting post-transplant adverse events.
MicroRNA-126 modulates angiogenesis and tube formation through enhancing epidermal growth factor-like domain 7 expression and phosphorylating PI3K/AKT signaling pathway
Authors: Li Qiang , Wang Zhong-ming , Wang Ai-yue , Xu Qiong-Guan , Fu Zhou-feng , He Shao-yu , Xu Peng-xiang
Published: April 2021

Introduction

Dysregulated angiogenesis is a critical characteristic for endothelial dysfunction disorders. This study aimed to determine functions of microRNA-126 in formation of tube and investigated the potential mechanisms.

Material and methods

The synthesized microRNA-126 control and microRNA-126 inhibitor plasmids were transfected into human umbilical-vein endothelial cells (HUVECs) using lipofectamine 2000 reagent. Cell counting kit-8 (CCK-8) was employed to measure proliferative capability of HUVECs. Transwell analysis was used to evaluate HUVECs invasive ability. Real time PCR (RT-PCR) was utilized to access epidermal growth factor-like domain 7 (EGFL7) and microRNA-126 mRNA transcription. Tube-forming capability in HUVECs was determined. Dual-luciferase assay and linear-regression analysis were conducted to measure interaction between EGFL7 and microRNA-126 molecule. Phosphoinositide-3-kinase/protein kinase-B (PI3K/AKT) signaling pathway associated molecules were evaluated using western blot assay.

Results

Silencing of microRNA-126 significantly enhanced proliferative capability and invasive ability of HUVECs compared to those of microRNA-126 control group (p<0.05). microRNA-126 silencing remarkably promoted tube formation and significantly up-regulated EGFL7 compared to those of microRNA-126 control group (p<0.05). microRNA-126 could interact with EGFL7 molecule. microRNA-126 was also negatively correlated with EGFL7 molecule in HUVECs (p<0.05). Silencing of microRNA-126 significantly enhanced p-PI3K/PI3K ratio compared to that of microRNA-126 control group (p<0.05). microRNA-126 silencing also remarkably increased p-AKT/AKT ratio compared to that of microRNA-126 control group (p<0.05).

Conclusions

microRNA-126 modulated angiogenesis and tube formation through increasing EGFL7 expression and phosphorylating PI3K/AKT signaling pathway.
Telomere-telomerase system status in patients with acute myocardial infarction with ST-segment elevation – relationship with oxidative stress
Authors: Vukašinović Aleksandra , Ostanek Barbara , Klisic Aleksandra , Kafedžić Srdjan , Zdravković Marija , Ilić Ivan , Sopić Miron , Hinić Saša , Stefanović Milica , Memon Lidija , Gaković Branka , Bogavac-Stanojević Nataša , Spasojević-Kalimanovska Vesna , Marc Janja , Nešković Aleksandar , Kotur-Stevuljević Jelena
Published: April 2021

Introduction

Telomeres are protective chromosomal ends. Short telomeres are a proven biomarker of biological aging. We aimed to find an association of telomere length and telomerase activity in circulating leukocytes and thromboaspirates of patients with acute myocardial infarction. Furthermore, association of the telomere-telomerase system with oxidative stress markers (as common risk factors for coronary artery disease (CAD)) was tested.

Material and methods

Patients were selected from the patients admitted to the intensive care unit with acute myocardial infarction with ST-segment elevation (STEMI), with the following inclusion criteria – STEMI patients between 18 and 80 years old of both genders and candidates for primary percutaneous coronary intervention, with infarction pain present for a maximum of 12 h. In all the patients leukocyte telomere length, telomerase activity and scores related to oxidative-stress status (Protective, Damage and OXY) were evaluated.

Results

Patients were divided into different groups: with stable angina pectoris (AP) (n = 22), acute myocardial infarction with: STEMI (n = 93), non-obstructive coronary arteries (MINOCA) (n = 7), blood vessel rupture (n = 6) at three time points, and compared to the group of 84 healthy subjects. Telomerase activity was significantly higher in all CAD sub-groups compared to the control group (AP = 0.373 (0.355–0.386), STEMI = 0.375 (0.349–0.395), MINOCA = 0.391 (0.366–0.401), blood vessel rupture = 0.360 (0.352–0.385) vs. CG = 0.069 (0.061–0.081), p < 0.001), while telomeres were significantly shorter in STEMI, MINOCA and blood vessel rupture groups compared to the control group (STEMI = 1.179 (0.931–1.376), MINOCA = 1.026 (0.951–1.070), blood vessel rupture = 1.089 (0.842–1.173) vs. CG = 1.329 (1.096–1.624), p = 0.030]. Values of OXY score were significantly higher in STEMI and MINOCA patients compared to the control group and AP patients (5.83 (4.55–7.54) and 10.28 (9.19–10.72) vs. 4.94 (3.29–6.18) and 4.18 (2.58–4.86), p < 0.001). Longer telomeres and higher telomerase activity were found in thromboaspirates, compared to the peripheral blood leukocytes in the same patients (1.25 (1.01–1.84) vs. 1.18 (0.909–1.516), p = 0.036; and 0.366 (0.367–0.379) vs. 0.366 (0.367–0.379), p < 0.001, respectively). In addition, telomere length and telomerase activity had good diagnostic ability to separate STEMI patients from healthy persons.

Conclusions

Leukocyte telomere length and telomerase activity can differentiate CAD patients from healthy persons, and relate CAD to oxidative stress.
Tumor necrosis factor alpha inhibitors and demyelinating disease: what is behind it?
Authors: Kucharz Eugeniusz Józef , Kotulska-Kucharz Anna
Published: April 2021

The development of tumor necrosis factor alpha (TNF-) inhibitors is probably one of the most significant advancement in the management of a number of inflammatory rheumatic disorders to date. High efficacy of the treatment is associated with relatively rare and very heterogeneous adverse reactions. The reactions are gradually recognized with an increase in number of the patients receiving medication and prolonged period of the drug usage. Neurological adverse events in patients receiving TNF- inhibitors are not common. This finding emergence a question of coincidental occurrence of the nervous system involvements as opposite to suggestion of induction of the nervous system disease or unmasking of latent disease due to the drug administration. Potential association of anti-TNF- therapy with demyelination is one of neurological adverse reaction, and is an important concern for every day clinical practice of rheumatologist as well as is an interesting problem from pathophysiological point of view.
Microvascular damage – a marker of specific organ involvement in mixed connective tissue disease?
Authors: Ornowska Sylwia , Chojnowski Marek , Felis-Giemza Anna , Dudek Łukasz , Olesińska Marzena
Published: April 2021

Mixed connective tissue disease (MCTD) is a complex entity, which incorporates features of systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), systemic sclerosis (SSc) and polymyositis/dermatomyositis (PM/DM). Nailfold videocapillaroscopy (NVC) is a simple, safe and non-invasive technique of capillary vessel assessment, allowing for qualitative and quantitative assessment of microcirculation. NVC plays a pivotal role in the diagnostic algorithm of connective tissue diseases, especially in systemic sclerosis (SSc). Numerous studies have shown a correlation between organ involvement and disease progression in SSc.

In the current literature, there are limited data on relationship between NVC and organ involvement in MCTD patients. In the present article the relevant literature describing NVC examination in patients with MCTD and comparisons with some clinical situations are discussed.
Methodik zur 3D-Analyse der Laderaumauslastung von Transportfahrzeugen
Authors: Vukovic Denis
Published: April 2021

Den Themenschwerpunkt der Arbeit bildet die sensorische Erfassung von 3D-Laderaumdaten mittels mehrerer Tiefenbildsensoren, um die Volumenauslastung von Transportfahrzeugen quantifizieren zu können. Die herausgearbeiteten Inhalte sind für Ingenieure, Logistiker und Wissenschaftler als besondere Wissensgrundlage anzusehen, um die unvermeidbaren Transportfahrten fortan ökonomischer und ökologischer durchführen zu können. Anhand

einer detaillierten Analyse werden die Auslastungsdefizite verdeutlicht und die ungenutzten Leistungspotenziale aufgezeigt. Aufbauend auf verschiedenen Versuchsreihen erfolgt die Systemauslegung zur Generierung der erforderlichen 3D-Laderaumdaten. Die erarbei teten Erkenntnisse werden anschließend in eine Auswertsystematik überführt und im Rahmen eines Praxisszenarios validiert. Die Arbeitsergebnisse bilden einen innovativen Beitrag, um zukünftig eine höhere Transporteffizienz zu erzielen.

Inhaltsverzeichnis

Kurzfassung ....................... VIII

Abstract ...........IX

Abkürzungsverzeichnis ........... X

1 Einführung ....................... 1

1.1 Motivation und Problemstellung .................... 1

1.2 Zielsetzung ............... 4

1.3 Struktur d...
Lipid Emulsion Treatment in Tricyclic Antidepressant Poisoning in Children: An Observational Cohort Study
Authors: Türe Esra , Akın Fatih , Yazar Abdullah , Kılıç Ahmet Osman
Published: April 2021

Tricyclic antidepressant (TCA) poisonings are among the most common childhood poisonings because of being cheap and readily available. In this manuscript, we aimed to share our experience with Intravenous lipid emulsions (ILE) treatment in addition to basic treatment steps and discussion of effectiveness of treatment in cases of poisoning caused by high-dose TCA intake. From the patients under 18 years of age who admitted to Pediatric Emergency Department due to drug intoxication between January 2014 and December 2019; those who had history of exposure to TCAs were included in our study. In conclusion of examination of six-year patient records, it was determined that there were a total of 619 intoxication cases and 108 (17.4%) of these were TCA poisoning. 21 (19.4%) patients who had hypotension, tachycardia and ECG changes which were refractory to all basic treatment steps were administered ILE. After ILE treatment, a marked improvement was observed in patients’ clinical and ECG findings, as well as vital signs. Early administration of ILE treatment in emergency departments for cases with hypotension, conduction disorder, dysrhythmia or widened QRS which are refractory to sodium bicarbonate is thought to prevent potential cardiovascular complications.
Urinary Tract Infections in Children
Authors: Poyrazoğlu Hakan M. , Yel Sibel
Published: April 2021

Urinary tract infections are one of the most common bacterial infections in children. It may cause severe complications in both acute and chronic periods. Escherichia coli is the most common microorganism that causes urinary tract infections in children. Recurrent urinary tract infection is a significant risk factor for kidney scarring. Early diagnosis and appropriate treatment of urinary tract infection, as well as determination of risk factors and prevention of recurrent urinary tract infections, should be the most critical goals in managing children with urinary tract infections.
Persepsi Alumni terhadap Kecerdasan Intelektual, Kecerdasan Emosional, dan Kecerdasan Spiritual Guru SMKN di Kendari
Authors: Hariani Hariani
Published: April 2021

Penelitian ini bertujuan untuk: 1) menentukan persepsi alumni tentang kecerdasan intelektual guru; 2) menentukan persepsi alumni tentang kecerdasan emosi guru; 3) menentukan persepsi alumni tentang kecerdasan spiritual guru. Objek penelitian ini adalah SMKN di Kendari, yang meliputi: SMKN 1, SMKN 2, dan SMKN 3. Populasi dalam penelitian ini adalah seluruh alumni SMKN 1 Kendari alumni SMKN 2 Kendari dan alumni SMKN 3 Kendari yang tamat 3 tahun keatas. Prosedur pengumpulan data dalam penelitian ini, dilakukan melalui langkah-langkah: Menyebarkan kuisioner kepada responden, dan melakukan wawancara mendalam (indept interview). Penelitian ini menyimpulkan: 1) Persepsi alumni terhadap kecerdasan intelektual guru SMKN di Kota Kendari memiliki persentase rata-rata sebesar 73,7% atau memiliki interpretasi baik; 2) Persepsi alumni terhadap kecerdasan emosional guru SMKN di Kota Kendari memiliki persentase sebesar 71,5% atau memiliki interpretasi baik; dan 3) Persepsi alumni terhadap kecerdasan spiritual guru SMKN di Kota Kendari memiliki persentase sebesar 72,6% atau dengan interpretasi baik.
Upaya Pelestarian Kesenian dan Budaya Lokal di Kabupaten Lampung Barat
Authors: Meriwijaya  , Luth
Published: April 2021

Penelitian tentang Upaya Pelestarian Kesenian dan Budaya Lokal di Kabupaten Lampung Barat ini difokuskan pada upaya pelestarian terhadap kesenian orkes gambus lampung. Metode yang digunakan pada penelitian ini adalah deskriftip kualitatif dengan berpedoman pada konsep-konsep studi kepustakaan dan wawancara. Hasil penelitian ini menunjukkan: Pertama, melakukan pendokumentasian dengan memanfaatkan kemajuan teknologi informasi yaitu pemanfaatan flatform digital youtube.com serta upaya pengenalan kepada generasi muda yang dilakukan dengan cara memberikan pelatihan-pelatihan cara berkesenian orkes gambus oleh para pegiat kesenian orkes gambus yang tersebar pada group-group orkes gambus yang ada di Kabupaten Lampung Barat. Kedua, membuat inovasi aransemen yang dihasilkan dari perpaduan antara kesenian orkes gambus dengan beberapa instrumen musik lainnya seperti alat musik keyboard dan Gamollan Pekhing. Ketiga, memberikan ruang tampil bagi para pegiat dan group-group kesenian orkes gambus pada acar-acara yang diselenggarakan oleh Pemerintah Daerah maupun acara yang dilaksanakan oleh masyarakat.
THE IMPACT OF JOB DESIGN, CONFLICT AND WORKPLACE STRESS ON ELEMENTARY THEACER’S JOB PERFORMANCE
Authors: M J Renwarin Joseph
Published: April 2021

This research aims to understand job performance of elementary teachers. This research is a explanatory and evaluative  research. The researcher want to know and analyze what are the impact of job design, conflict and stress to job performance. This research samples are 156 respondents with purposive samping method. The researchers use questionnaires disbursement by grouping of area. Data Calculation, For the relationship between two variables and analyze by Statistical Package for the Social Sciences (SPSS) software 22.0 version. All the variables as simultan and together had impact to job performance. Eventhough the results of research is all the variables have influence significants but there are some interesting points of view of this research result.
The Authority To Resolve Disputes For The Election Of Village Head In The Indonesian Area
Authors: Rosidi Ahmad , Nurcahyo Edy
Published: April 2021

The Village Head Dispute Resolution Mechanism should be regulated in detail and clearly in the norms that apply as law, which should also contain provisions regarding the Village Head dispute resolution mechanism, because these provisions are very important, where each region is required to make a Regional Regulation, related to the issue of the settlement of the village head election, which regulates the election of the village head, including providing arrangements for the settlement of village head election disputes. The Regional Regulation is the juridical basis used by the Head of government at the regional level, namely the Regent and Deputy Regent. This research is a nomative law research in which the approach used is the library or statutory approach through a study of the decisions on the results of the dispute over the village picades. The technique of collecting legal materials is carried out by means of library research. The analysis of legal materials is carried out in a qualitative deductive manner so that a conclusion can be drawn according to the needs of what has been studied. What has been researched is the regent's responsibility as a regional head which is carried out in accordance with the Regional Regulation to form an Election Committee, a Sub-District Supervisory Committee, a District Research Committee, and a Dispute Resolution Team formed directly by the East Lombok Regent. The pattern of village head election dispute resolution carried out by the local government is through deliberation with the roles of negotiator, mediator and conciliator.
Big Five Personality As Moderating The Effect Of Islamic Financial Planning
Authors: Aryandhana Mulyana Haris Dea , Taufiq Possumah Bayu , Abdul Fatah Dede
Published: April 2021

Islamic financial planning is a making process of financial planning in prudence to make it compatible with Islamic law in order to achieve the level of Al-Falah, that is the blessing of dunya and the salvation of akhira. Yet, with the importance of Islamic financial planning, the individuals who apply the Islamic financial planning in managing their wealth are still rare. So that this research intends to discover the influence of Islamic financial literacy towards each individual’s Islamic financial planning, and moderation effects given by the big five personality trait. The researcher used the simple regression test to find out the Islamic financial literacy effects towards the Islamic financial planning, and used the analysis of moderated multiple regression (MMR) to take the idea that the big five personality trait can moderate the Islamic financial literacy effects towards the Islamic financial planning. The data is collected by using the survey technique through questionnaire distribution to 115 moslem entrepreneurs in Bandung area. The result of this research shows that the Islamic financial literacy influences the Islamic financial planning significantly, and the big five personality trait partially moderates that influence. Furthermore, the conscientiousness and opennes to experience personality trait moderate the influence of Islamic financial literacy towards Islamic financial planning, while the other three of big five personality trait do not moderate.
Development of Teaching Material Supplement for Geography Subject Based on Local Wisdom of Kaili Da'a in Sigi Regency, Central Sulawesi
Authors: Abdul Latief Juraid , Listiqowati Ika , Abd Muis Arifuddin
Published: April 2021

The aim of the research was to develop a supplement of teaching materials for classXI geography subjects based on the local wisdom of the Kaili Da'a tribe in SigiRegency, Central Sulawesi, which is valid and feasible. Before developing thesupplement of teaching materials, first make preparations, namely: (1) Kaili Da'aresearch community in Dombu village, Marawola Sub district, Sigi Regency relatedto local wisdom values that are relevant to the geography material of XI high schoolclass. (2) Examines the Content Competency, Basic Competence, Teaching Materialand values of local wisdom that can be implemented in the geography learningmaterials of class XI high school. Teaching material supplements developed werevalidated by material experts and linguists. Products validated by material expertsand linguists show a percentage of 85% with qualifications that are very suitable foruse, after which a revision is made. The revised teaching material supplement wasthen tested for eligibility in small groups. The small group was 20 students of SMA 4Sigi, 20 students of SMA AL-Khairat Kalukubula, and 20 students of SMA 2 Sigi.The results of the feasibility test in the small group were 86.15% for SMA Negeri 4Sigi, 87.30% for SMA AL-Khairat Kalukubula and 86.73% for SMA Negeri 2 Sigi.These percentages respectively showed that the results of the development ofteaching material supplements received responses. Positive and qualify as eligible tobe used as a supplement of teaching materials.
The History of Conflict between Institutional and Native Hebrew in Israel
Authors: Mor Uri
Published: April 2021

Contemporary popular discourse on Hebrew prescriptivism betrays an interesting ambivalence: acceptance of institutional standards on the one hand and objection to normative intervention on the other. This ambivalence can be traced to the tension between the Language Committee and the Palestine Teachers’ Association during the Second Aliyah. Both advocated that Israel adopt a modern national language, but the former was in favor of a systematic language planning, while the latter was in favor of spontaneous language adoption. In the 1950s, a similar tension developed between the older generation and the Sabras (native speakers), whose generational identity had crystallized during the pre-State period. The language promoted by the former group was an institutional variety bound to a prescriptive norm, while that promoted by the latter was a native variety bound to conventional norms and real-life experience. The tension in these two episodes led to a deep cultural rift—one that is familiar to every Hebrew speaker in Israel—between the formal language of the state and the natural language of Hebrew speakers. A crosslinguistic perspective reveals a resemblance between Israeli Hebrew and European Late Dialect Selection languages, suggesting that the ambivalence towards prescriptivism in fact indicates ambivalence towards the national language, which is perceived, simultaneously, as a manifestation of a
REFLEXÕES SOBRE O ENSINO CONTEMPORÂNEO: REALIDADE E VIVÊNCIA
Authors: Vinhas Cleidson Teixeira , Schneider Vinícius Peter , Dilli Clóvis , Ginar Cristiano Telles
Published: April 2021

Esse trabalho tem por objetivo ressaltar as minhas experiências sobre o contexto da educação contemporânea. A educação visa propiciar condições para analisar e refletir criticamente sobre a realidade do ensino, o papel do educador reflexivo, investigador da própria ação, além de propiciar a vivência do cotidiano da escola como prática pedagógica e ética profissionalizante. Nesse trabalho, relato minhas experiências e pensamentos em relação á situação da educação na atualidade, e, sobretudo mostro uma reflexão acerca dessa experiência e sua importância para o desenvolvimento das competências necessárias para o exercício da profissão de orientador.
INEFICÁCIA SOCIAL DA REABILITAÇÃO CRIMINAL
Authors: Vinhas Cleidson Teixeira , Schneider Vinícius Peter , Dilli Clóvis , Ginar Cristiano Telles
Published: April 2021

O presente trabalho tem como objetivo analisar a evolução do Instituto da Reabilitação Criminal até os dias atuais, observando o contexto histórico deste instituto considerado por excelência, em países da Europa e América Latina. Seus pressupostos, aspectos humanos e sociais, e sua real eficácia na reinserção social do indivíduo egresso do sistema carcerário, bem como os que apenas foram submetidos a procedimentos de inquéritos policiais que restaram arquivados. Serão enfocados alguns casos práticos demonstrando a divergência doutrinária e jurisprudencial, quanto à eficácia e utilidade deste instituto no Brasil. As consequências suportadas pelos indivíduos estigmatizados no contexto social, as violações da honra, imagem, privacidade, e presunção de inocência.
SISTEMA CARCERÁRIO NO BRASIL
Authors: Estrella Robinson Daniel , Duarte Fernanda dos Santos , Nogueira Jacira Maria Muller , Moraes Luis Eduardo Machado , Lago Crisciani , Quevedo Diogo Silva de
Published: April 2021

A finalidade deste artigo é buscar conhecer como funciona o sistema carcerário brasileiro buscando o saber do que é prisão e pena e  apresentar um breve relato de um de seus maiores problemas a superlotação. Assim este artigo teve como objetivo buscar o saber o que é a Prisão e conhecendo os tipos de estabelecimentos prisionais citados na Lei de Execução Penal, o conhecimento do que é  Pena e suas modalidades citadas pelo Código Penal Brasileiro e apontar a problemática da Superlotação carcerária no Brasil que é um dos grandes problemas que impede a ressocialização.
LA IMPORTANCIA DE LAS TIC EN LA ASIGNATURA MATEMÁTICA
Authors: Vera Espinoza Luis Alberto , Yánez Rodríguez Marcos Alejandro
Published: April 2021

El objetivo del presente artículo es demostrar la importancia del uso de las TIC en la asignatura matemática ahora que el mundo se está convirtiendo en una sociedad digitalizada debido a la pandemia mundial. En este siglo XXI sin lugar a dudas los docentes deben recurrir a herramientas tecnológicas que le permitan de una u otra manera llevar el aprendizaje, para ello, deben tener en cuenta cuáles serían los aspectos relevantes en la creación de contenidos digitales que aporten innovación en la modalidad de enseñanza a distancia, la falta de investigaciones que permitan reflexionar sobre la importancia de usar herramientas digitales enfocadas en la asignatura matemática, influye en que no se apliquen, por lo que se debe evolucionar, aprender sobre el tema y pasar de esa manera tradicional de enseñar en esta área a una creativa que use metodologías activas, que involucre el uso de tecnologías que permitan realizar una enseñanza más dinámica y gamificada. Aparte de hacer ver esa importancia que tienen las nuevas tecnologías en la educación, también se desea hacer conocer ciertas herramientas que se pueden utilizar para enseñar matemática como: GeoGebra, Descartes, MathStudio, 3Dtin, entre otras. El tipo de investigación fue documental, con un enfoque cualitativo, además se usó el método deductivo, se determinó que realmente el uso de las tecnologías en la asignatura matemática es realmente necesario para motivar a los estudiantes y hacer las clases más innovadoras.
O RESGATE INTERDISCIPLINAR CONTEMPORÂNEO: UM ENGAJAMENTO CRÍTICO
Authors: Nunes Pires Guilherme
Published: April 2021

O objetivo do presente artigo é compreender o processo de resgate da interdisciplinaridade na atualidade a partir de um ponto de vista crítico. O processo de disciplinarização dos campos do conhecimento humano como conhecemos atualmente é algo recente na história humana. Contudo, vem se intensificando ao longo dos últimos dois séculos. As limitações em compreender a complexidade do mundo em disciplinas isoladas tem como resposta nas últimas décadas a tentativa de resgatar a perspectiva interdisciplinar do conhecimento humano. No entanto, procuraremos compreender esse processo a partir de uma perspectiva materialista, isto é, analisando os desdobramentos da evolução da moderna sociedade capitalista. É somente com a análise da relação entre conhecimento e as relações sociais determinadas é possível visualizar o grande panorama da disciplinarização do conhecimento e o atual resgate da interdisciplinaridade.
OPERACIONALIZAÇÃO E EFETIVAÇÃO DA POLÍTICA DE EDUCAÇÃO INCLUSIVA: O CASO DE UMA ESCOLA MUNICIPAL DE ILHÉUS-BA
Authors: de Carvalho Souza Eli Cristina , Trindade Clement Jessely , Barreto Santana Murilo
Published: April 2021

A educação inclusiva, diante da importância social envolvida, ganha cada vez mais destaque na literatura nacional e internacional. Este artigo objetiva analisar os avanços promovidos pela educação inclusiva na escola de Ilhéus-BA, bem como os aspectos operacionais limitam a efetivação das políticas públicas de inclusão. Como forma de chegar aos resultados esperados, a os dados coletados por meio de observação, bibliográfica e documental foram analisados qualitativamente. Como resultados observou-se que existem condições favoráveis ao desenvolvimento da educação inclusiva na escola pesquisada. Todavia, existem também aspectos operacionais que limitam a concretização da política de inclusão, a exemplo dos problemas e da falta de infraestrutura e materiais exclusivos. Conclui-se, portanto, que algumas questões operacionais contribuem e também atrapalham o correto desenvolvimento das políticas educacionais.
UMA ANÁLISE DISCURSIVA DO CORDEL CHUVA DE BALAS, DE GUALTER ALENCAR: SINTAXE, SENTIDO E HISTORICIDADE
Authors: Freire Tavares Edgley , Aianne Rebouças Marcela
Published: April 2021

Na cidade de Mossoró (RN), desenvolve-se um dispositivo cultural, político e econômico relativo a uma produção de memória acerca da cidade e do seu passado, sobretudo em torno da história da Resistência local frente ao ataque de Lampião e seu bando em 1927, que é amplamente propagada nos meios publicitários, jornalísticos, artísticos e literários do município. Todos esses veículos de informação pintam um quadro glorioso para a cidade, atribuindo uma reputação negativa e vil aos cangaceiros. Neste artigo, demonstraremos como esse cenário se constrói, respaldando-se nos elementos da Análise do Discurso Francesa, tomando por escopo analítico o cordel Chuva de balas, de Gualter Alencar, cuja análise discursiva nos permitirá elencar elementos argumentativos e discutir a relação entre sintaxe, sentido e história.
SUMAK KAWSAY: OS SABERES DOS POVOS ORIGINÁRIOS, O NOVO CONSTITUCIONALISMO E A EDUCAÇÃO BOLIVIANA
Authors: Leopoldina da Silva Ana , Antonio Fávero Lucas , Bonfim Fernandes Viviane
Published: April 2021

O presente artigo trata da nova Constituição da Bolívia e sua relação com os povos originários baseados no Bem Viver. Objetiva compreender os novos parâmetros estabelecidos pela nova carta bem como o rompimento com os ideais europeus neoliberais. Como objetivo específico trata da valorização dos conhecimentos dos povos originários e como esses saberes influenciam os processos educativos e as relações de cidadania. O método utilizado é o decolonialismo como propugnado por Aníbal Quijano, buscando trazer à tona as problemáticas latino-americanas e a revisão histórica das transformações ocorridas. O Bem Viver é característico dos povos originários, que possuem uma relação de complementaridade com a natureza. Assim conclui que a as normas constitucionais devem estar de acordo com as concepções adotadas pela maioria da sociedade. A Bolívia com maioria indígena mais de 36 etnias, corrige um erro histórico de interferência do pensamento europeu nas leis do país.
AÇÃO DIRETA DE INCONSTITUCIONALIDADE Nº 4234 E PATENTES PIPELINE: UMA PERSPECTIVA DECISÓRIA SOB A ÓTICA DA TEORIA INTERPRETATIVA DE RONALD DWORKIN
Authors: Carvalho de Lima Joyce Melo , Kallas Filho Elias
Published: April 2021

As patentes pipeline, previstas na Lei nº 9.279/96, possibilitam o reconhecimento retroativo de patentes de revalidação, divergindo dos requisitos exigidos na análise de outras patentes. O debate reside na sua constitucionalidade, quanto ao conceito e extensão do princípio da novidade e a ofensa ao direito adquirido. Assim, caberá ao Supremo Tribunal Federal atuar na Ação Direta de Inconstitucionalidade nº 4234, de modo a oferecer uma resposta justa e legítima à lide, propondo-se, para tanto, a teoria interpretativa de Dworkin, que sustenta ser possível uma resposta correta no direito, por uma questão de coerência e integridade. O objetivo deste estudo é constatar a resposta correta ao direito em litígio, por meio da aplicação de aludida teoria, com cerne na adequação e na justificação. Adota-se o método analítico qualitativo, expondo-se considerações a respeito do pipeline, bem como argumentos da ADI em debate, com fulcro nas etapas da interpretação construtiva de Dworkin, permitindo-se inferir o abuso da proteção conferida ao inventor pelo pipeline, por sobrepor interesses privados sobre públicos, e implicar negativamente em importantes setores do país.
ANÁLISE COLETIVA DO TRABALHO DOS TRABALHADORES DE APLICATIVOS
Authors: Pedroso Silveira Jorge William , Fontana de Laat Erivelton
Published: April 2021

As inovações tecnológicas aliadas à momentos economicamente instáveis gera a necessidade de uma reestruturação produtiva que acarreta na exclusão de alguns postos de trabalho para o surgimento de outros. Quando essa reestruturação por algum motivo se torna imediata, não há postos de trabalho para absorver a demanda excedente, o que consequentemente gera a informalidade e a busca por meios de sobrevivência em ocupações temporárias que por muitas vezes acabam se tornando fixas. O objetivo do presente estudo foi descrever como ocorre a relação entre trabalho e trabalhador nesse formato de prestação de serviços. Em grandes centros, motoristas e entregadores por aplicativos têm se tornado cada vez mais frequentes e entender, quem são e como se desenvolvem essas ocupações nessa condição, e para tal, utilizou-se a análise coletiva do trabalho em 39 motoristas e/ou entregadores do município de Curitiba-PR comparando os relatos destes trabalhadores com as definições expostas em estudos prévios. As respostas dos entrevistados corroboraram com a literatura que apresenta maioria para o sexo masculino, e predominância de adultos jovens, contudo, quanto à escolaridade, o presente estudo mostrou que o perfil tem se alterado, já que abrange em grande parte graduandos e até mesmo graduados, estes começando durante a graduação como temporário e não conseguindo se inserir no mercado; acabam se mantendo através desta prática. Apesar de o trabalho real exceder o prescrito nota-se que os trabalhadores têm buscado meios de executar da melhor maneira possível sua ocupação, tornando-se protagonistas em sua representação social.
AS ESTRATÉGIAS DE COMERCIALIZAÇÃO DOS MINIMERCADOS NA CIDADE DE PARINTINS-AM
Authors: Macêdo Ferreira Rosielen , do Socorro Pinto Simões Dayna , de Souza Barreto William
Published: April 2021

O objetivo deste estudo é compreender como as estratégias utilizadas pelos empreendedores, impactam no volume de vendas de seus empreendimentos no município brasileiro de Parintins no estado do Amazonas. A natureza do estudo consiste em uma pesquisa quantiqualitativa, descritiva, bibliográfica e de campo, no qual foi empregado como instrumento de coleta de dados, questionários semiestruturados, aplicado aos proprietários e clientes dos minimercados. O estudo demonstra que o município possui uma expressiva aglomeração de minimercados, os quais buscam se diferenciar dos concorrentes na conquista do seu público-alvo, por meio da identificação do perfil dos consumidores e o emprego de novas para sua fidelização. Portanto, os minimercados focam na qualidade, segurança, preço e localização, uma vez que, as compras realizadas nos mercados de grande porte se tornam, cada vez mais, um peso elevado no orçamento familiar da população que vivem na extrema pobreza. Os minimercados são influenciados pelos fatores culturais, sociais e econômicos, obrigando os pequenos empreendedores a investir em inovações para manter atuantes no mercado local nas regiões de baixa renda.
OS IMPACTOS NO PROCESSO DE COMPRAS DURANTE O PERÍODO DA PANDEMIA (COVID-19): UMA INVESTIGAÇÃO SOBRE A ROTINA DOS PROFISSIONAIS DE COMPRAS
Authors: Alexandre Miranda Pessoa Cavalcante Ricardo , Léo Ramos Gomes Rickardo
Published: April 2021

O atual contexto mundial de pandemia exigiu novas competências e habilidades. O objetivo geral deste estudo é a análise, através de dados levantados, do real cenário da rotina dos profissionais de compras durante a Pandemia da COVID-19, buscando o desenvolvimento de parâmetros norteadores, para os profissionais da área, para o enfrentamento de situações similares que fogem da curva da normalidade. Os objetivos específicos são os seguintes: verificar o impacto e os principais problemas na rotina dos profissionais de compras durante o período da Pandemia da COVID-19 no Brasil; demonstrar as oportunidades e alternativas criadas para a resolução de problemas no setor de suprimentos dentro das empresas; analisar os novos fatores que se tornaram decisórios na aquisição de insumos e matérias primas ou contratação de serviços. O procedimento metodológico adotado constituiu-se em uma investigação amparada por uma revisão bibliográfica quando buscou-se analisar, durante o período da pandemia da COVID-19, os impactos e reflexos do mercado perante a rotina do profissional de suprimentos. Ao final da investigação, à luz das opiniões coletadas, constata-se que o ajuste das empresas a essa nova realidade volátil, onde os números de vendas estão imprevisíveis e as dificuldades na compra de insumos têm exigido dos profissionais de compras um comportamento embasado em resiliência e flexibilidade, já que todos os elos da corrente de suprimentos (Supply Chain) estão tentando reduzir os impactos financeiros sem que ocorra a ruptura de estoques, evitando o descolamento entre os exigíveis e o faturamento de vendas.
LA AUDITORÍA Y SU INCIDENCIA EN LOS EMPRENDIMIENTOS SOSTENIBLES FUNDAMENTADOS EN EL FACTOR TRABAJO
Authors: Iza López Karina Johanna
Published: April 2021

La intención permanente de algunos sectores interés es determinar si el trabajo en los emprendimientos satisface o no las necesidades presentes del mercado sin afectar a las futuras y esto lo pretenden hacer mediante la práctica de una auditoría. Por ende, el propósito del presente estudio es abordar la incidencia de la auditoría en la sostenibilidad empresarial fundamentada en el factor trabajo. La indagación fue cuali-cuantitativa, con un diseño no experimental, tipo descriptiva y con un nivel documental. La micro, pequeñas y medianas empresa en el cantón Guaranda representan 969, mismas que pertenecen al sector económico popular y solidario y a partir de éste número se trabajó con 554. Para la recolección de datos se utilizó la encuesta misma que está integrada por preguntas dicotómicas y polinómicas. La auditoría si incide en los emprendimientos sostenibles fundamentados en el factor trabajo en inherencia a medir el cumplimiento de algunos elementos como: lo ético, económico, legal y filantrópico.
GESTIÓN CONTABLE DE LOS INVENTARIOS EN LOS AUTOSERVICIOS
Authors: Cedeño Cobos Melissa Nicole , Arroba Salto Inés
Published: April 2021

El tema de investigación la Gestión contable de los inventarios en los autoservicios, tiene como problema a investigar la compra en exceso o déficit de stock de los inventarios y el tratamiento contable del inventario por desconocimiento al aplicar la NIC 2 de inventarios y NIC 12 impuestos a las ganancias. Para poder sustentar, son citados temas como: la gestión contable de los inventarios, sistemas de inventarios, método de valuación de los inventarios, se utiliza herramientas de gestión contable de los inventarios. La metodología que se utilizó fue un diseño no experimental, con enfoque cualitativo aplicando el método deductivo y para poder llevar a cabo la investigación, las técnicas aplicadas fueron la observación, entrevista y análisis documental. Se diseña una propuesta de solución que consiste en un modelo de gestión que está dividido en cuatro fases: diagnosticar la situación actual del autoservicio, establecer lineamientos contables, aplicar herramientas de gestión contable de los inventarios y validar los resultados mediante los estados financieros y posteriormente en los indicadores financieros. Como conclusión al validar la aplicación de este modelo dio como resultado que el autoservicio va poder diversificar los productos, esto permitirá tener mayores ventas, el costo de venta va a disminuir al tener mejor control en la planificación de pagos, el inventario justo a tiempo diversificación de productos, de esta manera la empresa mejore su rentabilidad.
Realismo Crítico
Authors: De Carvalho Azevedo Anache Marcelo , Da Costa Laurencel Luiz
Published: April 2021

Partindo da concepção de que grande parte da realidade existe e opera independentemente da nossa consciência ou conhecimento dela e ainda de que a mesma não responde totalmente ao levantamento empírico ou ao exame hermenêutico, o presente artigo contempla as concepções filosóficas que abarcam o realismo crítico e lança luz sobre a problemática envolvida na relação entre teoria e realidade. Através das contribuições do precursor do movimento filosófico britânico contemporâneo do realismo crítico, Roy Bhaskar, pretende-se destacar a importância da ontologia na compreensão da realidade social, demonstrando que os Realistas abordam a causalidade de forma crítica, usando as regularidades parciais, fatos e eventos que encontramos no mundo social como um trampolim ou portal para entender os processos ou estruturas complexas, em camadas e contingentes que causam essas regularidades.
LONG TERM RESULTS OF REVERSE TRANSOSAL SUTURE OF FINGER FLEXOR TENDON TO DISTAL PHALANGE
Authors: Strafun S. , Bezuhlyi A. , Lysak A.
Published: April 2021

Aim: To analyze results of proposed reverse transosal suture. Materials: 264 cases (187 patients; 143 men, 44 women, age between 5 to 75 y. o.) of tendon fixation to distal phalanx by proposed technique was accepted in our research, after two stages flexor tendon grafting, in 2008—2019. On 2nd day after surgery - early full amplitude movement rehabilitation protocol (modification of Kleinart technique) was applied. Results: In an interim analysis of 109 patients treatment results, we noted complications associated with a transossal tendon suture to distal phalanx in 7.5 % (8/159) of cases: infectious complication — 1 case, serious nail growth disorders — 1, slight deformation of the nail plate — 5 cases, periodic pain in distant period — 1 case. To avoid complications associated with nail plate disorders, suture technique was modified by displacing the transcutaneous canal to the side of the nail germinal zone without incision on the back of the finger. No deformation of the nail plate was observed after changing of suture technique. Conclusions: flexor digitorum profundus tendon fixation technique minimizes trauma to surrounding tissues. Strong internal fixation of the tendon gives the possibility of early movements. Intermediate material analysis made it possible to change the suture technique to effectively eliminate the most common complications.