bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Corticosteroid Treatment for Non-Severe COVID-19 Pneumonia: A Propensity Score-Based Analysis
Authors: Yuan Mingli , Xu Xiaoxiao , Xia Dongping , Tao Zhaowu , Yin Wen , Tan Weijun , Hu Yi , Song Cheng
Published: June 2020

Background and objective:

The effects of corticosteroid treatment on non-severe COVID-19 pneumonia patients are unknown. To determine the impacts of adjuvant corticosteroid administrated to patients with non-severe COVID-19 pneumonia.

Method:

A retrospective cohort study based on propensity score analysis was designed to explore the effects of corticosteroid on several clinical outcomes.

Results:

One hundred thirty-two patients satisfied the inclusion criteria and 35 pairs were generated according to propensity score matching. Compared to non-corticosteroid group, the CT score on day 7 was significantly higher in corticosteroid group (8.6 (interquartile range [IQR], 2.8–11.5) versus 12.0 (IQR, 5.0–19.3), P = 0.046). In corticosteroid group, more patients progressed to severe cases (11.4% versus 2.9%, P = 0.353), hospital stay (23.5 days (IQR, 19–29 d) versus 20.2 days (IQR, 14–25.3 d), P = 0.079) and duration of viral shedding (20.3 days (IQR, 15.2–24.8 d) versus 19.4 days (IQR, 11.5–28.3 d), P = 0.669) were prolonged, while fever time (9.5 days (IQR, 6.5–12.2 d) versus 10.2 days (IQR, 6.8–14 d), P = 0.28) was shortened; however, all these data revealed no statistically significant differences.

Conclusion:

Corticosteroid might have a negative effect on lung injury recovery in non-severe COVID-19 pneumonia patients; however, the results of this study must be interpreted with caution because of confounding factors.
Indirect, Non-Thermal Atmospheric Plasma Promotes Bacterial Killing in vitro and Wound Disinfection in vivo Using Monogenic and Polygenic Models of Type 2 Diabetes (Without Adverse Metabolic Complications)
Authors: Cooley Chris R. , McLain John Mark , Dupuy Samuel D. , Eder Adrianna E. , Wintenberg Molly , Kelly-Wintenberg Kimberly , Wintenberg Alan , Collier J. Jason , Burke Susan J. , Karlstad Michael D.
Published: June 2020

A novel atmospheric plasma device that uses indirect, non-thermal plasma generated from room air is being studied for its effects on wound disinfection in animal wounds of monogenic and polygenic murine models of type 2 diabetes. As a proof-of-concept report, the goal of this study was to demonstrate the efficacy and safety of the indirect non-thermal plasma (INTP) device in disinfecting polycarbonate filters established with Pseudomonas aeruginosa (PAO1) biofilms as well as wound disinfection in diabetic murine wounds. Dorsal excisional wounds in BALB/c, polygenic TALLYHO, and monogenic db/db mice established with PAO1 infection all demonstrated a 3-log colony-forming unit (CFU) reduction when subjected to a course of 20-min INTP treatments. Importantly, blood glucose and body weights in these animals were not significantly impacted by plasma treatment over the study period. Plasma safety was also analyzed via complete blood count and comprehensive metabolic panels, showing no deleterious systemic effects after 3 consecutive days of 20-min plasma applications. Therefore, the results obtained demonstrated the Pseudomonas aeruginosa isolates were highly sensitive to INTP in vitro, CFU reduction of infectious Pseudomonas in wounds of diabetic mice after INTP treatment is far superior to that of non-treated infected wounds, and the application of INTP shows no indication of toxic effects. Our results are consistent with indirect non-thermal atmospheric plasma as a promising adjunct to disinfecting wounds.
Impact of Belatacept Conversion on Renal Function, Histology, and Gene Expression in Kidney Transplant Patients With Chronic Active Antibody-mediated Rejection
Authors: Kumar Dhiren , Raynaud Marc , Chang Jessica , Reeve Jeff , Yakubu Idris , Kamal Layla , Levy Marlon , Bhati Chandra , Kimball Pamela , King Anne , Massey Davis , Halloran Philip , Gupta Gaurav
Published: June 2020

Background.

Here, we present our initial experience with a prospective protocol of belatacept conversion in patients with chronic active antibody-mediated rejection (caAMR) and a high degree of chronicity at the time of diagnosis.

Methods.

We converted 19 patients (mean age, 45 ± 12 y) with biopsy-proven caAMR from tacrolimus to belatacept at a median of 44 months post–kidney transplant.

Results.

At a median of 29 months (interquartile range, 16–46 mo) postconversion, death-censored graft and patient survivals were 89% and 95%, respectively. When compared to a 1:2 propensity-matched control cohort from the INSERM U970 registry maintained on calcineurin inhibitor, the belatacept group had progressive improvement (P = 0.02) in estimated glomerular filtration rate from a mean of 33.9 ± 10 at baseline to 37.8 ± 13 at 6 months and 38.5 ± 12 mL/min/1.73 m2 at 12 months postconversion, as compared to a steady decline noted in the controls (36.2 [baseline] → 33.1 [6 mo] → 32.7 mL/min/1.73 m2 [12 mo] of follow-up). A paired histologic comparison of preconversion and postconversion (performed at median 9.5 mo postconversion) biopsies showed no worsening in microvascular inflammation or chronicity. The paired tissue gene expression analysis showed improved mean total rejection score (0.68 ± 0.26–0.56 ± 0.33; P = 0.02) and a trend toward improved antibody-mediated rejection score (0.64 ± 0.34–0.56 ± 0.39; P = 0.06).

Conclusions.

Here, we report that in patients diagnosed with caAMR who were not subjected to intensive salvage immunosuppressive therapies, isolated belatacept conversion alone was associated with stabilization in renal function. These results are bolstered by molecular evidence of improved inflammation.
Effects of Deep Brain Stimulation and Dopaminergic Medication on Excitatory and Inhibitory Spinal Pathways in Parkinson Disease
Authors: Andrews Jennifer C. , Roy François D. , Stein Richard B. , Ba Fang , Sankar Tejas
Published: June 2020

Purpose:

Abnormal activity within the corticospinal system is believed to contribute to the motor dysfunction associated with Parkinson disease. However, the effect of treatment for parkinsonian motor symptoms on dysfunctional descending input to the motor neuron pool remains unclear.

Methods:

We recruited nine patients with PD treated with deep brain stimulation and examined the time course of interaction between a conditioning pulse from transcranial magnetic stimulation and the soleus H-reflex. Patients with Parkinson disease were examined under four treatment conditions and compared with 10 age-matched control subjects.

Results:

In healthy controls, transcranial magnetic stimulation conditioning led to early inhibition of the H-reflex (76.2% ± 6.3%) at a condition-test interval of −2 ms. This early inhibition was absent when patients were OFF medication/OFF stimulation (132.5% ± 20.4%; P > 0.05) but was maximally restored toward control levels ON medication/ON stimulation (80.3% ± 7.0%). Of note, early inhibition ON medication/ON stimulation tended to be stronger than when medication (85.4% ± 5.9%) or deep brain stimulation (95.7% ± 9.4%) were applied separately. Late facilitation was observed in controls at condition-test intervals ≥5 ms but was significantly reduced (by 50% to 80% of controls) in Parkinson disease OFF stimulation at condition-test intervals ≥15 ms. The late facilitation was akin to control subjects when patients were ON stimulation.

Conclusions:

The present pilot study demonstrates that the recruitment of early inhibition and late facilitation is disrupted in untreated Parkinson disease and that medication and deep brain stimulation may act together to normalize supraspinal drive to the motor neuron pool.
Resident Use of EEG Cap System to Rule Out Nonconvulsive Status Epilepticus
Authors: Kyriakopoulos Paulina , Ding Joy Z. , Niznick Naomi , Lee Jong Woo , Sarkis Rani , Carpentier Josee , Fantaneanu Tadeu A.
Published: June 2020

Background:

Nonconvulsive status epilepticus (NCSE) requires an EEG for diagnosis and in many centers access may be limited. The authors aimed to test whether neurology residents can be trained to use and interpret full-montage EEGs using an EEG cap electrode system to detect NCSE while on-call.

Methods:

Neurology residents were trained to interpret EEG recordings using the American Clinical Neurophysiology Society critical care EEG terminology. Residents who achieved a score of 70% or higher in the American Clinical Neurophysiology Society certification test and attended a training session were eligible to use the EEG cap on-call with patients suspected of having NCSE. Residents' experience and interpretation of observed EEG patterns were evaluated using a questionnaire. Each EEG recording was independently reviewed by three epilepsy specialists to determine the interpretability of each study and whether the residents correctly identified the EEG patterns.

Results:

Sixteen residents undertook the training and 12 (75%) achieved a score of 70% or higher on the certification test. Seven of these residents performed 14 EEG cap studies between August 2017 and May 2018. The percent agreement between residents and electroencephalographers was 78.6% for EEG interpretability and 57.1% for description of EEG pattern. Residents did not miss any malignant patterns concerning for NCSE, which accounted for 1 of 14 EEGs but “overcalled” patterns as malignant in 3 of 14 recordings.

Conclusions:

This study suggests that neurology residents can be taught to perform and interpret EEGs using a cap system to monitor for NCSE. Additional training will help improve EEG interpretation and sensitivity.
Differentiation of Epileptic and Psychogenic Nonepileptic Seizures Using Single-Channel Surface Electromyography
Authors: Husain Aatif M. , Towne Alan R. , Chen David K. , Whitmire Luke E. , Voyles Shannon R. , Cardenas Damon P.
Published: June 2020

Purpose:

Epileptic seizures (ES) and psychogenic nonepileptic seizures (PNES) are difficult to differentiate when based on a patient's self-reported symptoms. This study proposes review of objective data captured by a surface electromyography (sEMG) wearable device for classification of events as ES or PNES. This may help clinicians accurately identify ES and PNES.

Methods:

Seventy-one subjects were prospectively enrolled across epilepsy monitoring units at VA Epilepsy Centers of Excellence. Subjects were concomitantly monitored using video EEG and a wearable sEMG epilepsy monitor, the Sensing Portable sEmg Analysis Characterization (SPEAC) System. Three epileptologists independently classified ES and PNES that contained upper extremity motor activity based on video EEG. The sEMG data from those events were automatically processed to provide a seizure score for event classification. After brief training (60 minutes), the sEMG data were reviewed by a separate group of four epileptologists to independently classify events as ES or PNES.

Results:

According to video EEG review, 17 subjects experienced 34 events (15 ES and 19 PNES with upper extremity motor activity). The automated process correctly classified 87% of ES (positive predictive value = 88%, negative predictive value = 76%) and 79% of PNES, and the expert reviewers correctly classified 77% of ES (positive predictive value = 94%, negative predictive value = 84%) and 96% of PNES. The automated process and the expert reviewers correctly classified 100% of tonic–clonic seizures as ES, and 71 and 50%, respectively, of non-tonic–clonic ES.

Conclusions:

Automated and expert review, particularly in combination, of sEMG captured by a wearable seizure monitor (SPEAC System) may be able to differentiate ES (especially tonic–clonic) and PNES with upper extremity motor activity.
Cyclic Alternating Pattern Analysis in Periodic Leg Movements in Sleep in Patients With Obstructive Sleep Apnea Syndrome Before and After Positive Airway Pressure Treatment
Authors: Benbir Senel Gulcin , Ozcelik Emel Ur , Karadeniz Derya
Published: June 2020

Purpose:

Cyclic alternating pattern (CAP) is known to increase in many conditions of sleep disruption and sleep disorders, including obstructive sleep apnea syndrome and periodic limb movements in sleep (PLMS). Periodic limb movements in sleep associated with obstructive sleep apnea syndrome may vanish after positive airway pressure treatment, may persist, or emerge at treatment night. Here, the authors aimed to investigate the underlying pathophysiology of nonvanishing, vanishing, or newly emergent PLMS.

Methods:

The authors designed a prospective study and included 10 patients with nonvanishing PLMS during positive airway pressure therapy, 10 patients with vanishing PLMS, 10 patients with newly emergent PLMS, and 10 patients without PLMS at both nights. The CAP analysis was performed in detail at diagnostic polysomnography recording and at positive airway pressure titration. The changes in CAP parameters were evaluated in regard to nonvanishing, vanishing, or newly emergent PLMS.

Results:

Periodic limb movements in sleep related to A1 subtype of CAP were observed to decrease under positive airway pressure titration more than PLMS related to A3 subtype of CAP. The A3 subtype of CAP was higher in patients with vanishing PLMS than those with newly emergent PLMS. The newly emergent PLMS were mostly related to A1 subtype of CAP compared with A3 subtype of CAP.

Conclusions:

This study showed that vanishing, nonvanishing, or newly emerging PLMS may indeed represent different underlying pathophysiology. The authors suggest that organization of sleep and preservation of ultradian rhythms during titration may determine whether PLMS will be vanished or persist. Newly emergent PLMS may probably arise from a separate central generator by the activation of higher cortical areas.
Insular Magnetoencephalography Dipole Clusters in Patients With Refractory Focal Epilepsy
Authors: Chourasia Nitish , Quach Michael , Gavvala Jay
Published: June 2020

Purpose:

The clinical significance of magnetoencephalography (MEG) dipole clusters in the insular region in patients with focal epilepsy, when present in conjunction with MEG dipole clusters in other regions of the brain is not known.

Methods:

All patients (adult and pediatric) with MEG dipole clusters involving the insula were retrospectively evaluated. Patients who underwent any form of surgical intervention were included in the study. Data obtained included age, sex, seizure characteristics, MRI brain, EEG, MEG, intracranial EEG, type of intervention, and seizure outcomes.

Results:

Twenty-four patients (12 adults and 12 pediatric) were included. Eight patients had one staged intervention and 16 had intracranial evaluation. Ten of 11 patients (91%) with insular coverage by stereotactic EEG had interictal insular spikes, and 5 of 11 patients (45%) had ictal onset from the insula. Combined Engel (I & II) outcomes were seen in five patients with resections/ablations involving the insula MEG dipole clusters as compared with eight patients where the insular MEG dipole clusters were not resected/ablated.

Conclusions:

Insular MEG dipole clusters identified on surface MEG correlated with interictal spikes in intracranial stereotactic electrode contacts in the insula. The presence of insular MEG dipole clusters, however, does not definitively imply a primary insular onset epilepsy.
Sperm sex ratio adjustment in a mammal: perceived male competition leads to elevated proportions of female-producing sperm
Authors: Firman Renée C. , Tedeschi Jamie N. , Garcia-Gonzalez Francisco
Published: June 2020

Mammal sex allocation research has focused almost exclusively on maternal traits, but it is now apparent that fathers can also influence offspring sex ratios. Parents that produce female offspring under conditions of intense male–male competition can benefit with greater assurance of maximized grand-parentage. Adaptive adjustment in the sperm sex ratio, for example with an increase in the production of X-chromosome bearing sperm (CBS), is one potential paternal mechanism for achieving female-biased sex ratios. Here, we tested this mechanistic hypothesis by varying the risk of male–male competition that male house mice perceived during development, and quantifying sperm sex ratios at sexual maturity. Our analyses revealed that males exposed to a competitive ‘risk’ produced lower proportions of Y-CBS compared to males that matured under ‘no risk’ of competition. We also explored whether testosterone production was linked to sperm sex ratio variation, but found no evidence to support this. We discuss our findings in relation to the adaptive value of sperm sex ratio adjustments and the role of steroid hormones in socially induced sex allocation.
Breastfeeding dynamically changes endogenous oxytocin levels and emotion recognition in mothers
Authors: Matsunaga Michiko , Kikusui Takefumi , Mogi Kazutaka , Nagasawa Miho , Ooyama Rumi , Myowa Masako
Published: June 2020

Breastfeeding behaviours can significantly change mothers' physiological and psychological states. The hormone oxytocin may mediate breastfeeding and mothers' emotion recognition. This study examined the effects of endogenous oxytocin fluctuation via breastfeeding on emotion recognition in 51 primiparous mothers. Saliva oxytocin was assessed before and after the manipulation (breastfeeding or holding an infant), and emotion recognition tasks were conducted. Among mothers who breastfed daily, mothers with more increased levels of oxytocin after breastfeeding showed more reduced negative recognition and enhanced positive recognition of adult facial expressions. These oxytocin functions accompanying breastfeeding may support continued nurturing behaviours and also affect the general social cognition of other adults beyond any specific effect on infants.
Populations of genetic circuits are unable to find the fittest solution in a multilevel genotype–phenotype map
Authors: Catalán Pablo , Manrubia Susanna , Cuesta José A.
Published: June 2020

The evolution of gene regulatory networks (GRNs) is of great relevance for both evolutionary and synthetic biology. Understanding the relationship between GRN structure and its function can allow us to understand the selective pressures that have shaped a given circuit. This is especially relevant when considering spatio-temporal expression patterns, where GRN models have been shown to be extremely robust and evolvable. However, previous models that studied GRN evolution did not include the evolution of protein and genetic elements that underlie GRN architecture. Here we use
toy
LIFE, a multilevel genotype–phenotype map, to show that not all GRNs are equally likely in genotype space and that evolution is biased to find the most common GRNs.
toy
LIFE rules create Boolean GRNs that, embedded in a one-dimensional tissue, develop a variety of spatio-temporal gene expression patterns. Populations of
toy
LIFE organisms choose the most common GRN out of a set of equally fit alternatives and, most importantly, fail to find a target pattern when it is very rare in genotype space. Indeed, we show that the probability of finding the fittest phenotype increases dramatically with its abundance in genotype space. This phenotypic bias represents a mechanism that can prevent the fixation in the population of the fittest phenotype, one that is inherent to the structure of genotype space and the genotype–phenotype map.
Sensitivity of collective outcomes identifies pivotal components
Authors: Lee Edward D. , Katz Daniel M. , Bommarito Michael J. , Ginsparg Paul H.
Published: June 2020

A social system is susceptible to perturbation when its collective properties depend sensitively on a few pivotal components. Using the information geometry of minimal models from statistical physics, we develop an approach to identify pivotal components to which coarse-grained, or aggregate, properties are sensitive. As an example, we introduce our approach on a reduced toy model with a median voter who always votes in the majority. The sensitivity of majority–minority divisions to changing voter behaviour pinpoints the unique role of the median. More generally, the sensitivity identifies pivotal components that precisely determine collective outcomes generated by a complex network of interactions. Using perturbations to target pivotal components in the models, we analyse datasets from political voting, finance and Twitter. Across these systems, we find remarkable variety, from systems dominated by a median-like component to those whose components behave more equally. In the context of political institutions such as courts or legislatures, our methodology can help describe how changes in voters map to new collective voting outcomes. For economic indices, differing system response reflects varying fiscal conditions across time. Thus, our information-geometric approach provides a principled, quantitative framework that may help assess the robustness of collective outcomes to targeted perturbation and compare social institutions, or even biological networks, with one another and across time.
Physiological silicon incorporation into bone mineral requires orthosilicic acid metabolism to SiO
4
4−
Authors: Chappell Helen F. , Jugdaohsingh Ravin , Powell Jonathan J.
Published: June 2020

Under physiological conditions, the predominant form of bioavailable silicon (Si) is orthosilicic acid (OSA). In this study, given Si's recognized positive effect on bone growth and integrity, we examined the chemical form and position of this natural Si source in the inorganic bone mineral hydroxyapatite (HA). X-ray diffraction (XRD) of rat tibia bone mineral showed that the mineral phase was similar to that of phase-pure HA. However, theoretical XRD patterns revealed that at the levels found in bone, the ‘Si effect’ would be virtually undetectable. Thus we used first principles density functional theory calculations to explore the energetic and geometric consequences of substituting OSA into a large HA model. Formation energy analysis revealed that OSA is not favourable as a neutral interstitial substitution but can be incorporated as a silicate ion substituting for a phosphate ion, suggesting that incorporation will only occur under specific conditions at the bone-remodelling interface and that dietary forms of Si will be metabolized to simpler chemical forms, specifically

SiO

4

4
−

. Furthermore, we show that this substitution, at the low silicate concentrations found in the biological environment, is likely to be a driver of calcium phosphate crystallization from an amorphous to a fully mineralized state.
On the coupling of mechanics with bioelectricity and its role in morphogenesis
Authors: Leronni A. , Bardella L. , Dorfmann L. , Pietak A. , Levin M.
Published: June 2020

The role of endogenous bioelectricity in morphogenesis has recently been explored through the finite volume-based code
BioElectric Tissue Simulation Engine
. We extend this platform to electrostatic and osmotic forces due to bioelectrical ion fluxes, causing cell cluster deformation. We further account for mechanosensitive ion channels, which, gated by membrane tension, modulate ion fluxes and, ultimately, bioelectrical forces. We illustrate the potentialities of this combined model of actuation and sensing with reference to cancer progression, osmoregulation, symmetry breaking and long-range signalling. This suggests control strategies for the manipulation of cell networks
in vivo
.
Coupling protocol of interlocked feedback oscillators in circadian clocks
Authors: Rashid Md. Mamunur , Kurata Hiroyuki
Published: June 2020

Circadian rhythms (approx. 24 h) show the robustness of key oscillatory features such as phase, period and amplitude against external and internal variations. The robustness of
Drosophila
circadian clocks can be generated by interlocked transcriptional–translational feedback loops, where two negative feedback loops are coupled through mutual activations. The mechanisms by which such coupling protocols have survived out of many possible protocols remain to be revealed. To address this question, we investigated two distinct coupling protocols: activator-coupled oscillators (ACO) and repressor-coupled oscillators (RCO). We focused on the two coupling parameters: coupling dissociation constant and coupling time-delay. Interestingly, the ACO was able to produce anti-phase or morning–evening cycles, whereas the RCO produced in-phase ones. Deterministic and stochastic analyses demonstrated that the anti-phase ACO provided greater fluctuations in amplitude not only with respect to changes in coupling parameters but also to random parameter perturbations than the in-phase RCO. Moreover, the ACO deteriorated the entrainability to the day–night master clock, whereas the RCO produced high entrainability. Considering that the real, interlocked feedback loops have evolved as the ACO, instead of the RCO, we first proposed a hypothesis that the morning–evening or anti-phase cycle is more essential for
Drosophila
than achieving robustness and entrainability.
Fear the reaper: ungulate carcasses may generate an ephemeral landscape of fear for rodents
Authors: Frank S. C. , Blaalid R. , Mayer M. , Zedrosser A. , Steyaert S. M. J. G.
Published: June 2020

Animal carcasses provide an ephemeral pulse of nutrients for scavengers that use them. Carcass sites can increase species interactions and/or ephemeral, localized landscapes of fear for prey within the vicinity. Few studies have applied the landscape of fear to carcasses. Here, we use a mass die-off of reindeer caused by lightning in Norway to test whether rodents avoided larger scavengers (e.g. corvids and fox). We used the presence and abundance of faeces as a proxy for carcass use over the course of 2 years and found that rodents showed the strongest avoidance towards changes in raven abundance (
β =
−0.469, s.e. = 0.231,
p
-value = 0.0429), but not fox, presumably due to greater predation risk imposed by large droves of raven. Moreover, the emergence of rodent occurrence within the carcass area corresponded well with the disappearance of raven during the second year of the study. We suggest that carcasses have the potential to shape the landscape of fear for prey, but that the overall effects of carcasses on individual fitness and populations of species ultimately depend on the carcass regime, e.g. carcass size, count, and areal extent, frequency and the scavenger guild. We discuss conservation implications and how carcass provisioning and landscapes of fear could be potentially used to manage populations and ecosystems, but that there is a gap in understanding that must first be bridged.
The sustainable development of coal mines by new cutting roof technology
Authors: Yu Bin , Tai Yang , Gao Rui , Yao QiangLing , Li Zhao , Xia Hongchun
Published: June 2020

China consumes more than 3.6 billion tons of coal every year. In the meanwhile, coal accounts for over 60% of the energy consumption sector. Therefore, the sustainable development of coal mines is a problem that needed to be solved by the Chinese government. During the coal resources recovery process, the protective coal pillars between the adjacent working faces lead to a vast waste of coal resources. In order to mitigate the resource-wasting issue, a new technology of roof cutting with chain arm retaining roadway was put forward in this paper. First, the procedures of retaining roadway, roof-cutting parameters and the damage ranges of roadway surrounding rock induced by roof cutting with chain arm were analysed. Then, the working resistance of the temporary support equipment is given when using the new technology to retain the roadway. Next, the roof-cutting height, the temporary support equipment selection, working resistance of portal support and support parameters of the bolt and anchor cables were optimized based on the numerical calculation. The industrial experiment of retaining roadway by roof cutting with chain arm was carried out in a working face. The surrounding rock damage was lowered and controlled with the application of chain arm roof-cutting technology. Also, it was found that the variation range of the uniaxial compressive strength was only 5%, resulting in the roof damage range of 82 mm. The new technology has proved a potentially wide application in the coal mining industry with prosperous economic and safety improvement.
Is the perception of intent by association football officials influenced by video playback speed?
Authors: Mather George , Breivik Simon
Published: June 2020

Recent research on motion perception indicates that when we view actions in slow-motion, the perceived degree of intent behind those actions can increase. Slow-motion replays are widely used in the checking and review of refereeing decisions by video assistant referees (VAR) in association football. To test whether the decisions of referees are subject to such a bias, 80 elite English professional football officials made decisions about 60 incidents recorded in professional European leagues (recorded as fouls, yellow-card offences or red-card offences by the on-field referee). Both real-time (1×) and slow-motion (0.25×) playback speeds were used. Participants had no prior knowledge of the incidents, playback speeds or disciplinary sanctions relating to each clip. Three judgements were made about each incident: extent of contact, degree of intent, and disciplinary sanction. Results showed an effect of playback speed on decision-making, but not a consistent bias due to slow-motion. Instead the distinction between yellow-card and red-card offences was clearer: Under slow-motion, yellow-card incidents were judged as less severe, and red-card incidents are judged as more severe, thus enhancing the distinction between these offences. These results are inconsistent with previous scientific reports that perceived intent is heightened by slow video playback speed.
Timing of geological events in the lunar highlands recorded in shocked zircon-bearing clasts from Apollo 16
Authors: Joy K. H. , Snape J. F. , Nemchin A. A. , Tartèse R. , Martin D. M. , Whitehouse M. J. , Vishnyakov V. , Pernet-Fisher J. F. , Kring D. A.
Published: June 2020

Apollo 16 soil-like regolith breccia 65745,7 contains two zircon-bearing clasts. One of these clasts is a thermally annealed silica-rich rock, which mineralogically has affinities with the High Alkali Suite (Clast 1), and yields zircon dates ranging from 4.08 to 3.38 Ga. The other clast is a KREEP-rich impact melt breccia (Clast 2) and yields zircon dates ranging from 3.97 to 3.91 Ga. The crystalline cores of both grains, which yield dates ofca3.9 Ga, have undergone shock pressure modification at less than 20 GPa. We interpret that the U-Pb chronometer in these zircon grains has been partially reset by the Imbrium basin-forming event when the clasts were incorporated into the Cayley Plains ejecta blanket deposit. The zircon grains in Clast 1 have been partially decomposed, resulting in a breakdown polymineralic texture, with elevated U, Pb and Th abundances compared with those in the crystalline zircon. These decomposed areas exhibit younger dates around 3.4 Ga, suggesting a secondary high-pressure, high-temperature event, probably caused by an impact in the local Apollo 16 highlands area.
Biomechanical modelling of spinal tumour anisotropic growth
Authors: Katsamba Ioanna , Evangelidis Pavlos , Voutouri Chrysovalantis , Tsamis Alkiviadis , Vavourakis Vasileios , Stylianopoulos Triantafyllos
Published: June 2020

Biomechanical abnormalities of solid tumours involve stiffening of the tissue and accumulation of mechanical stresses. Both abnormalities affect cancer cell proliferation and invasiveness and thus, play a crucial role in tumour morphology and metastasis. Even though, it has been known for more than two decades that high mechanical stresses reduce cancer cell proliferation rates driving growth towards low-stress regions, most biomechanical models of tumour growth account for isotropic growth. This cannot be valid, however, in tumours that grow within multiple host tissues of different mechanical properties, such as the spine. In these cases, structural heterogeneity would result in anisotropic growth of tumours. To this end, we present a biomechanical, biphasic model for anisotropic growth of spinal tumours. The model that accounts for both the fluid and the solid phase of the tumour was used to predict the evolution of solid stress and interstitial fluid pressure in intramedullary spinal tumours and highlight the differences between isotropic and anisotropic growth. Varying the degree of anisotropy, we found considerable differences in the shape of the tumours, leading to tumours of more realistic ellipsoidal shapes.
Frequency dispersion in the fractional Langmuir approximation for the adsorption–desorption phenomena
Authors: Barbero Giovanni , Evangelista Luiz Roberto , Lenzi Ervin K.
Published: June 2020

We propose that a kinetic equation of fractional order may be used to account for the frequency dispersion of the effective parameters in the framework of the Langmuir approximation for the adsorption–desorption phenomena. A frequency dependence of these parameters naturally arises in this formalism, indicating that it may play a similar role of a generalization of the Langmuir isotherm obtained from a homogeneous distribution of relaxation times. The fractional approach formalism opens the possibility to consider different relaxation regimes characterizing the interfacial behaviour of electrolytic cells, and may be a powerful tool to interpret complex impedance spectroscopy data.
On the modelling and testing of a laboratory-scale Foucault pendulum as a precursor for the design of a high-performance measurement instrument
Authors: Cartmell Matthew P. , Faller James E. , Lockerbie Nicholas A. , Handous Eva
Published: June 2020

An integrated study is presented on the dynamic modelling and experimental testing of a mid-length Foucault pendulum with the aim of confirming insights from the literature on the reliable operation of this device and setting markers for future research in which the pendulum may be used for the measurement of relativistic effects due to terrestrial gravity. A tractable nonlinear mathematical model is derived for the dynamics of a practical laboratory Foucault pendulum and its performance with and without parametric excitation, and with coupling to long-axis torsion is investigated numerically for different geographical locations. An experimental pendulum is also tested, with and without parametric excitation, and it is shown that the model closely predicts the general precessional performance of the pendulum, for the case of applied parametric excitation of the length, when responding to the Newtonian rotation of the Earth. Many of the principal inherent performance limitations of Foucault pendulums from the literature have been confirmed and a general prescription for design is evolved, placing the beneficial effect of principal parametric resonance of this inherently nonlinear system in a central mitigating position, along with other assistive means of response moderation such as excitational phase control through electromagnetic pushing, enclosure, and the minimization of seismic and EMC noise. It is also shown, through a supporting analysis and calculation, that although the terrestrial measurement of the Lense–Thirring (LT) precession by means of a Foucault pendulum is certainly still within the realms of possibility, there remains a very challenging increase in resolution capability required, in the order of 2 × 10
9
to be sure of reliable detection, notwithstanding the removal of extraneous motions and interferences. This study sets the scene for a further investigation in the very near future in which these challenges are to be met, so that a new assault can be made on the terrestrial measurement of LT precession.
Dilation of subglacial sediment governs incipient surge motion in glaciers with deformable beds
Authors: Minchew B. M. , Meyer C. R.
Published: June 2020

Glacier surges are quasi-periodic episodes of rapid ice flow that arise from increases in slip rate at the ice–bed interface. The mechanisms that trigger and sustain surges are not well understood. Here, we develop a new model of incipient surge motion for glaciers underlain by sediments to explore how surges may arise from slip instabilities within a thin layer of saturated, deforming subglacial till. Our model represents the evolution of internal friction, porosity and pore water pressure within the till as functions of the rate and history of shear deformation, and couples the till mechanics to a simple ice-flow model. Changes in pore water pressure govern incipient surge motion, with less permeable till facilitating surging because dilation-driven reductions in pore water pressure slow the rate at which till tends towards a new steady state, thereby allowing time for the glacier to thin dynamically. The reduction of overburden (and thus effective) pressure at the bed caused by dynamic thinning of the glacier sustains surge acceleration in our model. The need for changes in both the hydromechanical properties of the till and the thickness of the glacier creates restrictive conditions for surge motion that are consistent with the rarity of surge-type glaciers and their geographical clustering.
Predicting population extinction in lattice-based birth–death–movement models
Authors: Johnston Stuart T. , Simpson Matthew J. , Crampin Edmund J.
Published: June 2020

The question of whether a population will persist or go extinct is of key interest throughout ecology and biology. Various mathematical techniques allow us to generate knowledge regarding individual behaviour, which can be analysed to obtain predictions about the ultimate survival or extinction of the population. A common model employed to describe population dynamics is the lattice-based random walk model with crowding (exclusion). This model can incorporate behaviour such as birth, death and movement, while including natural phenomena such as finite size effects. Performing sufficiently many realizations of the random walk model to extract representative population behaviour is computationally intensive. Therefore, continuum approximations of random walk models are routinely employed. However, standard continuum approximations are notoriously incapable of making accurate predictions about population extinction. Here, we develop a new continuum approximation, thestate-space diffusion approximation, which explicitly accounts for population extinction. Predictions from our approximation faithfully capture the behaviour in the random walk model, and provides additional information compared to standard approximations. We examine the influence of the number of lattice sites and initial number of individuals on the long-term population behaviour, and demonstrate the reduction in computation time between the random walk model and our approximation.
Cretaceous diversity and disparity in a lacewing lineage of predators (Neuroptera: Mantispidae)
Authors: Lu Xiumei , Wang Bo , Zhang Weiwei , Ohl Michael , Engel Michael S. , Liu Xingyue
Published: June 2020

Mantidflies (Mantispidae) are an unusual and charismatic group of predatory lacewings (Neuroptera), whereby the adults represent a remarkable case of morphological and functional convergence with praying mantises (Mantodea). The evolutionary history of mantidflies remains largely unknown due to a scarcity of fossils. Here, we report the discovery of a highly diverse palaeofauna of mantidflies from the mid-Cretaceous (lowermost Cenomanian) of Myanmar. The raptorial forelegs of these mantidflies possess highly divergent morphological modifications, some of which are unknown among modern mantidflies, e.g. the presence of forked basal profemoral spines or even the complete loss of foreleg spine-like structures. A phylogenetic analysis of Mantispidae reveals a pattern of raptorial foreleg evolution across the family. The high species diversity and disparate foreleg characters might have been driven by diverse niches of predator–prey interplay in the complex tropical forest ecosystem of the mid-Cretaceous.
From disorganized equality to efficient hierarchy: how group size drives the evolution of hierarchy in human societies
Authors: Perret Cedric , Hart Emma , Powers Simon T.
Published: June 2020

A manifest trend is that larger and more productive human groups shift from distributed to centralized decision-making. Voluntary theories propose that human groups shift to hierarchy to limit scalar stress, i.e. the increase in cost of organization as a group grows. Yet, this hypothesis lacks a mechanistic model to investigate the organizational advantage of hierarchy and its role on its evolution. To fill this gap, we describe social organization by the distribution of individuals’ capacity to influence others. We then integrate this formalization into models of social dynamics and evolutionary dynamics. First, our results demonstrate that hierarchy strongly reduces scalar stress, and that this benefit can emerge solely because leaders and followers differ in their capacity to influence others. Second, the model demonstrates that this benefit can be sufficient to drive the evolution of leader and follower behaviours and ultimately, the transition from small egalitarian to large hierarchical groups.
Skull morphology diverges between urban and rural populations of red foxes mirroring patterns of domestication and macroevolution
Authors: Parsons K. J. , Rigg Anders , Conith A. J. , Kitchener A. C. , Harris S. , Zhu Haoyu
Published: June 2020

Human activity is drastically altering the habitat use of natural populations. This has been documented as a driver of phenotypic divergence in a number of wild animal populations. Here, we show that urban and rural populations of red foxes (Vulpes vulpes) from London and surrounding boroughs are divergent in skull traits. These changes are primarily found to be involved with snout length, with urban individuals tending to have shorter and wider muzzles relative to rural individuals, smaller braincases and reduced sexual dimorphism. Changes were widespread and related to muscle attachment sites and thus are likely driven by differing biomechanical demands of feeding or cognition between habitats. Through extensive sampling of the genusVulpes, we found no support for phylogenetic effects on skull morphology, but patterns of divergence found between urban and rural habitats inV. vulpesquantitatively aligned with macroevolutionary divergence between species. The patterns of skull divergence between urban and rural habitats matched the description of morphological changes that can occur during domestication. Specifically, urban populations of foxes show variation consistent with ‘domestication syndrome’. Therefore, we suggest that occurrences of phenotypic divergence in relation to human activity, while interesting themselves, also have the potential to inform us of the conditions and mechanisms that could initiate domestication. Finally, this also suggests that patterns of domestication may be developmentally biased towards larger patterns of interspecific divergence.
Does concomitant bacteraemia hide the fungi in blood cultures? An in vitro study
Authors: Oz Yasemin , Onder Sukran , Alpaslan Ekin , Durmaz Gul
Published: June 2020

Introduction. Polymicrobial infections including yeasts and bacteria are not rare and patients with polymicrobial bloodstream infection have higher early and overall case fatality rates. The diagnosis of invasive fungal and bacterial infections is mainly based on blood culture.

Aim. The aim was to reveal the effect of concomitant bacteraemia on the detection of fungi from blood cultures in the presence of polymicrobial bloodstream infections involving Candida and non-Candida fungi and to show the superiority of blood culture bottles including selective fungal media in such situations.

Methodology. Twenty-four polymicrobial bloodstream infection models – involving one fungus and one bacterium – were constituted by using clinical blood culture isolates (

Escherichia coli

,

Staphylococcus aureus

,

Pseudomonas aeruginosa

, Candida albicans, Candida glabrata, Fusarium solani and Trichosporon asahii). The Plus Aerobic/F (PAF) and Mycosis IC/F (MICF) culture bottles were used with the BACTEC 9240 device. After a bottle signalled positive, direct microscopic examination and subcultures on agar plates were performed.

Results. All of fungi that were inoculated alone and in combination were detected by both direct microscopic examination and subcultures on agar plates from MICF bottles, whereas direct microscopic examination only revealed the bacterial agents from PAF bottles including combinations. Furthermore, fungal growth was hidden by bacterial growth on blood agar subcultures from PAF bottles including combinations of F. solani, C. glabrata or T. asahii with bacteria.

Conclusion. Blood culture bottles including selective fungal media that can allow selective growth of fungi and earlier detection of some species should be preferred in addition to non-selective blood culture bottles, especially in specific patient populations. Further, the use of selective agar plates such as inhibitory mould agar may contribute to the solution of this problem in clinical laboratories.
The impact of the undetected COVID-19 cases on its transmission dynamics
Authors: Saha Sujata , Saha Sumanta
Published: June 2020

Objective

The COVID-19 pandemic is currently ongoing. Presently, due to the unavailability of a definitive vaccine to decrease its acquiring, it’s essential to understand its transmissibility in the community by undetected cases to control its transmission. This study aims to study this context using mathematical modelling.

Methods

A COVID-19 transmission model was framed that estimated the basic reproduction number (R0, a measurement of disease risk) using the next-generation method. It explored the contribution of exposed and infected (detected and undetected) individuals, and environmental pathogen to the overall risk of infection spreading, utilizing the publicly reported data of this infection in Maharashtra between March 22, 2020, and May 4, 2020. A sensitivity analysis was performed to study the effect of a rising number of undetected cases to R0.

Results

The estimated basic reproduction number is R0 = 4.63, which increases rapidly with the rise in the undetected COVID-19 cases. Although the exposed individuals made the largest contribution to infection transmission (R1 = 2.42), the contaminated environment also played a significant role.

Conclusions

It is crucial to identify the individuals exposed and infected to COVID-19 disease and isolate them to control its transmission. The awareness of the role of fomites in infection transmission is also important in this regard.
Psychological consequences of the Flint Water Crisis: A systematic review
Authors: Brooks Samantha K. , Patel Sonny S.
Published: June 2020

Given the COVID-19 outbreak, these unprecedented times pose many urgent dilemmas about how to support the mental health of communities. The goal of this research is to summarize existing literature on the mental health impact of the recent Flint Water Crisis. In March 2020, we searched five databases for literature exploring the psychological consequences of the crisis. Main findings were extracted. 132 citations were screened and eleven included in the review. Results suggest a negative psychological effect caused by the water crisis, including anxiety and health worries, exacerbated by lowered trust in public health officials, uncertainty about the long-term impacts of the crisis, financial hardships, stigma, and difficulties seeking help. There was evidence that concerns about tap water continued even after the state of emergency was lifted. With a possible compounded effect to residents of Flint with the recent COVID-19 pandemic, the results highlight the need for more resources for psychological health interventions in Flint as well as a need for local governments and health authorities to regain the trust of those affected by the Flint Water Crisis.