bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Pertumbuhan, Leverage, Profitabilitas, dan Kebijakan Dividen terhadap Nilai Perusahaan
Authors: Timotius Timotius , Setyawan Ignatius Roni
Published: February 2023

Penelitian ini bertujuan untuk memperoleh bukti empiris atas pengaruh dari pertumbuhan, leverage, profitabilitas dan kebijakan dividen terhadap nilai perusahaan pada perusahaan manufaktur di Bursa Efek Indonesia (BEI) tahun 2017-2020. Penelitian ini menggunakan 144 data sampel yang dipilih melalui metode purposive sampling dari 36 perusahaan. Data penelitian diolah menggunakan Eviews 9.0. Hasil penelitian membuktikan bahwa pertumbuhan berpengaruh positif dan signifikan terhadap nilai perusahaan, leverage berpengaruh positif dan signifikan terhadap nilai perusahaan, profitabilitas berpengaruh positif dan signifikan terhadap nilai perusahaan dan kebijakan dividen berpengaruh positif dan signifikan terhadap nilai perusahaan.

 

This research is made to obtain empirical evidence about the effect of growth, leverage, profitability, and dividend policy on firm value on manufacture companies in the Indonesian Stock Exchange in the period of 2017-2020. This research is conducted by taking 144 sample determined by purposive sampling method of 36 companies. Research data is processed using Eviews 9.0. The result indicate that growth has positive and significant effect on firm value, leverage has positive and significant effect on firm value, profitability has positive and significant effect on firm value and dividend policy has positive and significant effect on firm value.
Pengaruh Karakter dan Kondisi Ekonomi Nasabah terhadap Pembiayaan Bermasalah (Studi pada BMT Nurul Iman Madani Aek Nabara)
Authors: Andriani Rika , Rasyid Arbanur , Matondang Zulaika
Published: February 2023

Para pengusaha kecil dan menengah dan calon debitur yang bergerak di bidang bisnis menjadi sasaran pembiayaan yang dilakukan oleh Baitul Maal Wat Tamwil. Perbedaan dalam sifat atau karakter dan kondisi ekonomi nasabah menjadi salah satu penyebab terjadinya kredit macet atau pembiayaan bermasalah, dan tidak sedikit dari nasabah tersebut lari dari tanggung jawab mengembalikan pinjaman yang telah diberikan. Karakter merupakan sifat yang berkaitan dengan kejiwaan, akhlak kepribadian seseorang, yang menjadi pembeda satu dengan yang lainnya. Sementara Kondisi ekonomi dapat diartikan sebagai kondisi seseorang dapat menghasilkan keuangan untuk memenuhi kebutuhan pokok dan kebutuhan hidup lainnya, serta kemampuan untuk membayar pinjaman pembayaran. Non Performing Financing mengacu pada pembiayaan yang disebabkan oleh pelanggan tidak menempati waktu angsuran dan tidak memenuhi persyaratan kontrak. Hasil penelitian menunjukkan tidak terdapat pengaruh yang signifikan antara variabel karakter dengan variabel pembiayaan bermasalah, sedangkan terdapat pengaruh yang signifikan antara variabel kondisi ekonomi dengan variabel pembiayaan bermasalah. Variabel karakter dan variabel kondisi ekonomi memiliki pengaruh yang simultan terhadap pembiayaan bermasalah.Kata Kunci: Karakter, Kondisi Ekonomi, Pembiayaan Bermasalah
Santripreneur at Al-Ustmani: Efforts to Realize Sharia-Based Entrepreneurship in Islamic Boarding Schools
Authors: Adinugraha Hendri Hermawan
Published: February 2023

Abstrak Penelitian ini memiliki maksud untuk menjabarkan santripreneur di Al-Ustmani dalam upaya untuk mewujudkan kewirausahaan berbasis syariah di pondok pesantren. Pendekatan yang digunakan penulis yaitu pendekatan kualitatif. Teknik pengumpulan data yang digunakan dalam penelitian yaitu participan observation, in depth interview dan document review. Teknik pengolahan data dilakukan melalui tahapan editing dan organizing. Analisis data kualitatif mengikuti konsep Miles and Huberman and Spradeley. Teknik pengecekan keabsahan data adalah dilakukan dengan triangulasi. Hasil temuan penelitian ini menunjukkan bahwa kegiatan kewirausahaan yang ada di Al-Ustmani sudah mampu menumbuhkan jiwa wirausaha santri. Kegiatan kewirausahaan di Al-Ustmani juga menanamkan nilai-nilai kewirausahaan berbasiskan ekonomi syariah. Aktivitas kewirausahaan dalam perspektif ekonomi Islam seringkali dipraktikkan oleh Nabi, istrinya, para sahabat, dan juga para pengikutnya. Karena Islam bukan hanya mengkaji tentang entrepreneurship, tetapi langsung mempraktikkannya dalam kehidupan nyata. Al-Ustmani telah menyiapkan program kegiatan pembelajaran yang sungguh-sungguh dapat mendorong tumbuh dan berkembangnya spirit kewirausahaan para santri agar menjadi Santripreneur.Abstract This study aims to describe the santripreneurs in Al-Ustmani in an effort to realize sharia-based entrepreneurship in Islamic boarding schools. The approach used by the author is a qualitative approach. Data collection techniques used in the study were participant observation, in-depth interviews and document review. Data processing techniques are carried out through editing and organizing stages. Qualitative data analysis follows the concept of Miles and Huberman and Spradeley. The technique of checking the validity of the data is done by tringulation. The findings of this study indicate that entrepreneurial activities in Al-Ustmani have been able to foster the entrepreneurial spirit of students. Entrepreneurial activities at Al-Ustmani also instill entrepreneurial values based on sharia economics. Entrepreneurial activities in the perspective of Islamic economics are often practiced by the Prophet, his wife, his companions, and also his followers. Because Islam is not only studying entrepreneurship, but directly practicing it in real life. Al-Ustmani has prepared a program of learning activities that can truly encourage the growth and development of the entrepreneurial spirit of the students to become Santripreneurs.
Non-Muslim Determinants Using Islamic Financial Institutions
Authors: Zein Aliman Syahuri
Published: February 2023

Abstrak Lembaga keuangan syariah memiliki market share yang cukup besar, terdiri dari masyarakat Muslim maupun non Muslim. Berdasarkan data yang ada, jumlah non Muslim di Padangsidimpuan mencapai 8,27% dari total jumlah penduduk. Namun yang telah menjadi nasabah lembaga keuangan syariah belum mencapai 10% dari jumlah yang ada. Tujuan penelitian menganalisis pengaruh lokasi, pelayanan, fasilitas, keuntungan, religiusitas, produk, dan promosi terhadap perilaku nasabah. Penelitian ini merupakan jenis penelitian kuantitatif, dengan menggunakan analisis regresi linier berganda. Sampel penelitian berjumlah 57 orang nasabah non Muslim. Teknik sampling yang digunakan adalah acidental sampling. Hasil penelitian menyimpulkan bahwa secara parsial lokasi, fasilitas, stimulan religi, dan produk tidak memiliki pengaruh yang signifikan terhadap keputusan non Muslim memilih lembaga keuangan syariah di Padangsidimpuan. Sementara itu, secara parsial pelayanan, keuntungan, dan promosi memiliki pengaruh yang signifikan terhadap keputusan non Muslim memilih lembaga keuangan syariah di Padangsidimpuan. Namun secara simultan, semua variabel bebas memiliki pengaruh signifikan terhadap variabel terikat.  Abstract Islamic financial institutions have a large market share, consisting of Muslim and non-Muslim communities. Based on existing data, the number of non-Muslims in Padangsidimpuan reaches 8.27% of the total population. However, those who have become customers of Islamic financial institutions have not yet reached 10% of the existing amount. The research objective is to analyze the effect of location, service, facilities, benefits, religiosity, product and promotion on customer behavior. This research is a type of quantitative research. The research sample is 57 non-Muslim. The sampling technique used is accidental sampling. The results, that partially location, facilities, religious stimulants, and products did not have a significant effect on the decision of non-Muslims to choose an Islamic financial institution. Meanwhile, partially, services, benefits, and promotions have a significant influence on the decision of non-Muslims to choose Islamic financial institutions. But simultaneously, all independent variables have a significant influence on the dependent variable.
The Effect Of Relationship Marketing, Food Quality And Service Quality On Customer Satisfaction With Purchase Decisions As Intervening Variables
Authors: Dwiyanti Selvi Ainul Inayah , Saifuddin Muchammad
Published: February 2023

This study aims to know role of purchase decision as a mediating effect between relationship marketing, food quality dan service quality on customer satisfaction, the sampling used 100 respondents. The data was analyzed using Partial Least Square (PLS) which consists of two stages, outer model and the inner model with the help of the SmartPLS program. 3.2 The results show that Relationship Marketing has significant effect on customer satisfaction. Relationship Marketing has significant effect on purchasing decisions. Service Quality has significant effect on customer satisfaction. Purchase decisions have significant effect on customer satisfaction. Relationship Marketing through Purchase Decisions has significant effect on Customer Satisfaction. With the results of this study, it is hoped that it can be used as input and evaluation material to improve food quality and service quality in the hope that Nelongso fried chicken has more value than other restaurants in the minds of consumers.
Alpha 1 Antitrypsin Deficiency: Characterization of Patients in a Tertiary Hospital
Authors:   Paediatric Department, Hospital De Braga, Braga, Portugal, Vilaça Joana
Published: February 2023

AAT deficiency (AATD) is an autosomal recessive disorder characterized by decreased or dysfunctional AAT production
Studi Penambatan Molekuler dan Simulasi Dinamika Molekuler Senyawa Turunan Furanokumarin terhadap Reseptor Estrogen Alfa (ER-α) Sebagai Anti Kanker Payudara
Authors: Elfita Lina , Apriadi Anjas , Supandi Supandi , Dianmurdedi Shanifa
Published: February 2023

Kanker payudara menjadi salah satu jenis kanker dengan penderita terbanyak baik di dunia maupun di Indonesia, Reseptor Estrogen Alfa (ER-α) menjadi target utama karena dapat mengatur transkripsi gen dan jalur persinyalan interseluler. Penelitian ini bertujuan untuk menganalisis afinitas dan kestabilan ikatan kompleks ligan senyawa turunan furanokumarin dengan reseptor estrogen alfa. Metode yang digunakan secara in silico atau komputasi yaitu penambatan molekuler menggunakan software AutoDock dan simulasi dinamika molekuler menggunakan software Gromacs. Hasil penambatan molekuler senyawa Bergamottin sebagai senyawa uji paling baik dengan nilai ∆G = -8,98 kkal/mol. Sedangkan ligan pembanding 4-Hydroxytamoxifen dengan nilai ∆G = -11,34 kkal/mol. Hal tersebut menunjukkan bahwa afinitas 4-Hydroxytamoxifen masih lebih baik daripada Bergamottin. Kestabilan ikatan ligan-reseptor dikonfirmasi dengan simulasi dinamika molekuler menunjukkan 4-Hydroxytamoxifen lebih stabil berikatan dengan ER-α berdasarkan parameter Root Mean Square Deviation (RMSD), Root Mean Square Fluctuation (RMSF), Radius of Gyration dan ikatan hidrogen. 4-Hydroxytamoxifen memiliki afinitas dan kestabilannya lebih baik dalam berikatan dengan reseptor estrogen alfa (ER-α)
Measurements of T5 Shock Tunnel Freestream Temperature, Velocity, and Composition
Authors: Finch Peter M. , Girard Julian J. , Schwartz Tal , Strand Christopher L. , Hanson Ronald K. , Yu Wesley M. , Austin Joanna M. , Hornung Hans G.
Published: February 2023

We report on measurements of rotational and vibrational temperature, velocity, and concentrations of nitric oxide (NO) in freestream flows at the T5 reflected shock tunnel at California Instistute of Technology. Quantities were measured at 50 kHz by tunable diode laser absorption spectroscopy using five lasers simultaneously to sample 27 quantum state-specific transitions. To isolate core flow measurements from the shear flow surrounding it, optical flow-cutter arms were designed. Two sets of arms with differing optical path lengths were used to assess freestream spatial uniformity. This study consists of nine total experiments (“shots”) spanning four nominal conditions with reservoir enthalpy 8–21 MJ/kg and flow velocity 3.5–5.5 km/s. Freestream measurements generally imply thermal equilibrium of the rotational and vibrational temperatures except at lower-enthalpy conditions. We compare temperature measurements with predictions from five species air simulations and find reasonable agreement at lower-enthalpy conditions but underprediction of NO concentrations. At higher-enthalpy conditions, we observed transitory agreement in temperature but overprediction of NO concentrations. Measured and simulated velocity generally agree well across all conditions. Carbon monoxide, water, and potassium were also detected in the T5 flow, and their concentrations are reported where relevant.
Knowledge, Attitudes, Practices and Mental Health Status of Trainees in Selected Health Institutes Regarding COVID-19 in Uttar Pradesh, India
Authors: Bhoil Rohan , Paul Budhaditya , Srivastava Ankita
Published: February 2023

On 11 March 2020, the World Health Organization (WHO) declared the novel coronavirus (COVID-19) outbreak a global pandemic. Knowledge about COVID-19 is an important determinant towards successful disease control. This study was designed to elucidate the knowledge, attitudes and practices (KAP) and mental health status regarding COVID-19 amongst trainees of two institutes in the state of Uttar Pradesh, India. The cross-sectional study was conducted from January to March 2021. A bilingual survey recorded the responses of 400 participants from the institutes. Variables, such as sex, age, marital status, occupation, level of education, number of family members and living place, were collected in a structured proforma. Unstandardised regression coefficients (95%) were used for evaluating the association among variables with KAP and mental health during COVID-19. The statistical significance level was determined at p<0.05.The mean correct answer score regarding knowledge about COVID-19 was 23.5 (SD=2.1), indicating an overall 87% correct rate. The mean correct answer score regarding attitude towards COVID-19was 18.4 (SD=2.3), indicating an overall 87.2% correct rate. The mean correct answer score regarding practice towards COVID-19 was 35 (SD=3.4), indicating an overall 89.7% correct rate. The mean correct answer score regarding mental health status during COVID-19 was 24 (SD=4.7), indicating an overall 80% correct rate. Thus, the results showed that being female; belonging to a higher age group; having a healthcare related occupation; being married; and having a higher level of education were significantly associated with higher KAP test scores. Furthermore, belonging to a higher age group; having a healthcare related occupation; being married; and having a higher level of education were significantly associated with poor mental health.
Örgütsel Politika ve Duygusal Emeğin Örgütsel Yeniliğe Etkisi
Authors: AK Murat , KURTBOĞAN Hasan
Published: February 2023

Bu çalışmanın amacı örgütsel politika algısı ile duygusal emeğin; örgütsel yeniliği etkileyip etkilemediğinin ampirik olarak ortaya konulmasıdır. Çalışmada nicel araştırma yöntemlerinden tarama araştırma yöntemi kullanılmış olup analiz çeşidi olarak ilişkisel analiz kullanılmıştır. Örgütsel politika ve duygusal emeğin, örgütsel yenilik üzerindeki etkisini incelemek amacıyla, SPSS programı kullanılarak çoklu regresyon analizi gerçekleştirilmiştir. Analizler sonucunda, örgütsel politika ve duygusal emek puanlarının örgütsel yenilik puanını yordama gücü istatistiksel olarak anlamlı bulunmuştur. Bu bağlamda araştırma sonucunda; mevcut uygulanmakta olan politikaların ve çalışanların duygusal emeğinin, örgütsel yenilik algılamaları üzerinde anlamlı ve pozitif bir etkisinin söz konusu olduğu anlaşılmaktadır. Dolayısıyla örgütsel yenilik hedefleyen örgütlerin, örgütsel politikalarını bu yönde belirlemesinden ayrıca çalışanların duygusal emek algılamalarını da yenilik uygulamalarını besleyecek ve destekleyecek ölçüde yönlendirmeleri gerektiğinden söz edilebilir.
Features of the Style of the Letters of Bishop Theophan the Recluse: Lexical and Phraseological Aspects
Authors: Yao Song
Published: February 2023

Purpose. The purpose of this article is to analyze the characteristics of lexical terms in Russian texts from the perspective of lexical rhetoric. So the article analyzes the peculiarities of the vocabulary and phraseology of the letters from “Letters on the Christian Life” of the famous preacher, religious teacher Bishop Theophan the Recluse.

Results. Through the analysis of the selected specific vocabulary and idioms, we have obtained the following results. One of the distinguishing features of these epistolary texts is polystylism, which manifests itself in a free combination of vocabulary of foreign origin, colloquial words, and Church Slavonicisms. If borrowed vocabulary is used in a stylistically neutral function, then colloquial elements are stylistically marked and used in order to establish communication with addressees. Such vocabulary creates a kind of trusting relationship between the addresser and addressees. Phraseological units and constructions, which are author’s, occasional transformations of phraseological elements, serve the same purpose. Church Slavonic inclusions in letters are a kind of communicative fragments, intexts within letters, conditioned in thematic (definitions of theological concepts) and genre (quotations from the Bible and prayer addresses).

Conclusion. In summary, through this research, we can derive some new theories of linguistic application, and through it, we can enrich the interpretation of corpus and dictionaries.
Means of Expressing Permission in the Business Language of the 18th Century
Authors: Rudnev D. V. , Borisova T. Yu.
Published: February 2023

Purpose. The aim of the article is to describe the system of means of expressing permission in the language of documents of the 18th century. On the basis of linguistic material extracted from collections of published documents, patterns of expression of permission and their dynamics during the 18th century are revealed.

Results. In the time of Peter the Great, there was an activation of the means of expressing permission inherited from the previous era (constructions with the word volya, the predicative adverb vol'no and adjective volen), and at the same time new ways of expressing permission arose: the verbs dozvolyat'sya, pozvolyat'sya (polonisms), the phrase ne zapreshchat'sya. Later, new models remained in the Russian business language, and those inherited from the prePetrine business language mostly disappeared. Throughout the 18th century, there was a competition between the verbs dozvolyat'sya and pozvolyat'sya. In the Petrine era, the verb moch' also started to be used in documents, but its widespread use begins in the second half of the 18th century.

Conclusion. In the era of the reign of Catherine II, a new period of enrichment of the means of expressing permission began. European (most likely German) calques imet' pravo, imet' vlast', vlasten appeared in the language, of which the calque imet' pravo turned out to be particularly productive. A variety of models for expressing permission had different sources of origin and presented the idea of permission in different ways.
The Poetics of Color “Cattleya Labiata” in the Lyrics by Vladimir Nabokov: Data from the Dictionary of Lexical Combinations
Authors: Pavlova L. V. , Romanova I. V.
Published: February 2023

Purpose. The study is devoted to the description of the poetic world of V. V. Nabokov-lyricist, more precisely – its color fullness on the example of purple. The method of multidimensional lexicographic description of the color aspect of Nabokov's poetic world is proposed. The presented article offers observations on the dictionary of lexical combinations with a color component, the data for which were obtained using the original software system “Hypertext Search for Companion-words in Author’s Texts”.

Results. The use of the software package makes it possible to find stable groups of lexemes in the works of a poet, “passing” from poem to poem. Tokens are adjacent to each other at some distance and usually do not show obvious connections between themselves. These are lexical combinations. They mark common language, general poetic and individual author associations that arise unconsciously in authors. Some of purple’s satellites are obviously attracted by the sound. Purple partners organize the space, emphasizing the top of the vertical and outlining the horizontal landscape; indicate the time; note the presence of plants and humans, mark mystical (religious) consciousness. The properties and characteristics of objects and phenomena associated with purple are due to the play of light. A positive emotional state associated with purple is obvious.

Conclusion. In his “purple” lexical combinations Nabokov follows the golden age of Russian poetry, describing the celestial sphere or characterizing the earth's surface, but radically diverges, transferring this color association to the plant world, the mystical region and man. The proximity of purple to God or Russian, as well as to the characteristics of a cheerful disposition, is Nabokov’s idiosyncrasy.
Dermatitis Neglecta Presenting as Smegmolith in Healthy Adult Male
Authors: Singh Bhabani S. T. P. , Mohapatra Liza , Nayak Manoj Kumar , Dixit Nibedita
Published: February 2023

Smegmoliths are hard local accumulations of smegma, mostly seen in children with phimosis. This is due to difficulty in adequate cleansing of the subpreputial area. It is not a common finding in adults. We report a case of smegmolith occurring in an adult male as a manifestation of dermatitis neglecta. Dermatitis neglecta occurs secondary to improper hygiene when a person avoids cleansing a part of his body either due to physical disability, neurodeficits or psychiatric disorder. It should be diagnosed promptly as only cleansing the part with nwormal saline would effectively treat this condition without the need for any sophisticated investigation and intervention. In the index case, smegmolith has occurred because of dermatitis neglecta in an otherwise healthy male without any underlying comorbidity.
Images for publication – ten tips
Authors: Kaliyadan Feroze
Published: February 2023

The manuscript covers the most common errors seen in images submitted for publication and suggests some tips to avoid these errors.
How to Convert Thesis into Publication
Authors: De Dipankar , Das Nilay Kanti
Published: February 2023

The postgraduate medical education regulation demands that the postgraduates should have publications and presentations to their credit to make them eligible to appear at the postgraduate degree examination. Unless the thesis is published, the scientific world won’t be updated of the research finding and the entire effort a postgraduate has put forward in conceptualising, designing and implementing the research goes into vain. The present article aims to give an overview to residents on how to proceed about planning and execution of publication of their thesis. Although everyone wants to submit in the best journal, there are limitations to be considered and choosing the right journal is an important step. Knowing the thrust area and readership of the journal and also the quality of the thesis helps to make the choice. The article highlights into the introspection of the quality of the thesis and tips to choose the article type best suited for publication. Drafting of the different sections of the article is highlighted with reference to CONSORT guidelines. Drafting of the title along with choosing the running title and key words, abstract, introduction, methodology, results, discussion, limitations and conclusion are highlighted along with tips on drafting the references too. In the end, we also discuss on how to face rejection and the way forward.
Undergraduate Dermatology: Interactive Teaching Strategies in a Lecture
Authors: Arora Pooja
Published: February 2023

An evolving need for learner centric approach in teaching calls for innovative methods that can be utilised by teachers in the classroom and clinical setting. In this article, we have outlined few teaching strategies that can be used to make lectures more engaging and participative. These methods not only promote active learning but also increase attention, and encourage critical thinking in the audience.
Investigation of the structure-properties relationship of modified green PBS-DLS copolymers and their processability by 3D printing and electrospinning
Authors: Zarei Moein , Żwir Marek J. , Wiśniewska Ewa , Michalkiewicz Beata , El Fray Miroslawa
Published: February 2023

In this study, the synthesis and physico-chemical properties of poly(butylene succinate-dilinoleic succinate) (PBS-DLS) copolymers modified with hydrophilic poly(ethylene glycol)(PEG) differing in segmental composition are discussed in order to determine their structure-properties relationship and translate it to their processability. The copolymers, containing bio-based monomers such as succinic acid and dilinoleic diol, were successfully synthesized by two-step transesterification and polycondensation, and collected directly from the reactor as crystallized filaments suitable for 3D printing. Chemical characterization indicated the formation of expected functional ester groups and incorporation of PEG into polymer chain. Crystallized copolymers revealed spherulitic morphology and phase transitions which were dependent from the segmental composition. Interestingly, incorporation of 5 wt% PEG into copolymers containing higher hard segments content (70 wt%) disturbed the banded spherulitic morphology of copolymers, contributed to the increase of elasticity up to 830%, and reduced the water contact angle indicating improvement of copolymers hydrophilicity. We examined the role of segmental composition on 3D printing and demonstrate that copolymers can also be turned into 400 to 600 nm nanofibers via electrospinning. Further, all copolymers showed excellent cell proliferation thus confirming the suitability of these materials for biomedical applications.
Kinetic quantitative analysis reveals the suppression of Sup35NM amyloid fibril nucleation by liquid-liquid phase separation.
Authors: Fukuyama Mao , Nishinami Suguru , Maruyama Yoko , Ozawa Taiki , Tomita Shunsuke , Ohhashi Yumiko , Kasuya Motohiro , Gen Masao , Chatani Eri , Shiraki Kentaro , Hibara Akihide
Published: February 2023

Elucidating the link between amyloid fibril formation and liquidliquid phase separation (LLPS) is crucial in understanding the pathologies of various intractable human diseases. However, the effect of condensed protein droplets generated by LLPS on nucleation (the initial step of amyloid formation) remains unclear because of the lack of available quantitative analysis techniques. In this study, we developed a method to fix micrometer-sized droplets in gel to examine the kinetics of amyloid nucleation in droplets. This method allows long-term observation of protein droplets with known droplet volumes. By combining this method with image analysis, we determined the nucleation dynamics in droplets of a prion disease model protein, Sup35NM, at the single-event level. We found that the nucleation was unexpectedly suppressed by LLPS above the critical concentration (C*) and enhanced below C*. We also revealed that the lag time in the Thioflavin T assay, a semi-quantitative parameter of amyloid nucleation rate, does not necessarily reflect nucleation tendencies in droplets. Our results suggest that LLPS can suppress amyloid nucleation, contrary to the conventional hypothesis that LLPS enhances it. We believe that the proposed quantitative analytical method will provide insights into the role of LLPS from a pathological perspective.
Analysis of Resources Applied to Rationalize Elimination Mechanisms
Authors: Gao Sean , Outlaw Taylor , Liang-Lin Jason , Feng Alina , Shimomura Reika , Roizen Jennifer , Cox Charles
Published: February 2023

Acid-base chemistry, an essential component of the undergraduate chemistry curriculum, is introduced in general chemistry and expanded on in organic chemistry. Previous research has linked student understanding of acid-base chemistry to success in organic chemistry. However, there remains a paucity of information regarding how students apply acid-base chemistry concepts in the context of organic reaction mechanisms. The purpose of this study was to analyze the resources activated in second-semester organic chemistry students understanding while solving problems on E1, E2, and E1cB elimination reactions. The resources activated were probed using a mixed-methods approach comprising survey assessments and think-aloud interviews, and the data were analyzed both quantitatively and qualitatively following a validated set of scoring criteria. The results align with existing findings that students focus upon surface level structural information and use more familiar resources when solving organic problems. Acid-base resources were activated more often than reaction-specific resources such as conformational analyses or carbocation rearrangements. Acid-base resources aid students in successfully analyzing reaction mechanisms, but in general, additional resources must be activated to rationalize specific mechanisms and explain the products formed. The implications for teaching, assessment, and future research are discussed.
Desafíos del Aprendizaje Profundo en la Visión por Computador
Authors: Ayma Quirita Victor Hugo , Achanccaray Diaz Pedro Marco , Arauco Canchumuni Smith Washington , Soto Vega Pedro Juan
Published: February 2023

La visión por computador es un área de estudio en la inteligencia artificial que se enfoca en el desarrollo de técnicas computacionales para percibir el mundo a través de entradas visuales, como videos o imágenes. El aprendizaje profundo ha demostrado ser una técnica eficiente para el análisis e interpretación de datos visuales. Sin embargo, afronta innumerables desafíos según su aplicación en las diferentes tareas de la visión por computador. Este panel reúne un grupo de expertos en aprendizaje profundo, quienes ofrecerán información sobre su aplicación y los desafíos en sus respectivas áreas de investigación con relación a la visión por computador.
HYDROGEOLOGICAL CHARACTERIZATION OF LOCAL GROUNDWATER RESERVOIRS IN THE KŁODZKO LAND (SUDETES - SW POLAND) BASED ON AN ANALYSIS OF THE DISCHARGES OF SPRINGS
Authors:   University of Wroclaw, Institute of Geological Sciences, pl. M. Borna 9, 50-204 Wroclaw, Poland, OLICHWER Tomasz
Published: February 2023

The hydrogeological characteristics of the two types of local groundwater reservoirs found in the Kłodzko Land (Sudetes) have been made based on the analysis of the discharge of springs in Szczytna and Różanka. In the first of these spring discharge points, water flows out of Upper Cretaceous sandstones and mudstones. The other spring is associated with fractured and weathered mica schists and gneisses. The Różanka spring characterized by greater discharge variability than the fissured porous outflow in Szczytna. The latter one, due to the slower rate of water filtration in the rock medium, belongs to stable springs in terms of discharge. The local groundwater reservoir located in sedimentary rocks characterized by a much higher value of the groundwater volume stored (264,000 m3) than the reservoir consisting of weathered and fractured crystalline rocks (1,918 m3). In the case of the reservoir draining by Szczytna spring, the rate of groundwater exchange in the active zones is about 66 weeks. A distinctly shorter time (12 weeks) is necessary to exchange water in the fractured crystalline bedrock. The hydraulic conductivity for the aquifers in Szczytna and Różanka, calculated based on the recession coefficient, differ substantially from each other. They are 4.64 and 24.9 m/d, respectively.
The effects of β-myrcene on simulated driving and divided attention: A double-blind, placebo-controlled, crossover pilot study
Authors: Johnson Mark B. , McKnight Scott , Taylor Eileen P. , Mechtler Laszlo , Ralyea Christopher C.
Published: February 2023

Background. β-myrcene, one of the most common terpenes found in cannabis, has been associated with sedation. We propose that β-myrcene contributes to driving impairment even in the absence of cannabinoids. Aim. To conduct a double-blind, placebo-controlled crossover pilot study of the effect of β-myrcene on performance on a driving simulator. Method. A small sample (n=10) of participants attended two experimental sessions, one in which they were randomized to receive 15 mg of pure β-myrcene in a capsule versus a canola oil control. Each session, participants completed a baseline block and three follow-up blocks on a STISIM driving simulator. Results. β-myrcene was associated with statistically significant reductions in speed control and increased errors on a divided attention task. Other measures did not approach statistical significance but fit the pattern of results consistent with the hypothesis that β-myrcene impairs simulated driving. Conclusions. This pilot study produced proof-of-principle evidence that the terpene β-myrcene, an agent commonly found in cannabis, can contributes to impairment of driving-related skills. Understanding how compounds other than THC affect driving risk will strengthen the field’s understanding of drugged driving.
Understanding Changes in Social Cannabis Use among Young Adults During the COVID-19 Pandemic: A Social Network Analysis
Authors: DiGuiseppi Graham , Fedorova Ekaterina , Conn Bridgid , Lankenau Stephen , Davis Jordan , Ataiants Janna , Wong Carolyn
Published: February 2023

Introduction. As the COVID-19 pandemic has caused historic morbidity and mortality and disrupted young people’s social relationships, little is known regarding change in young adults’ social cannabis use following social distancing orders, or other factors associated with such changes before and during the pandemic. Methods. 108 young adult cannabis users in Los Angeles reported on their personal (egocentric) social network characteristics, cannabis use, and pandemic-related variables before (July 2019 – March 2020) and during the COVID-19 pandemic (August 2020 – August 2021). Multinomial logistic regression identified factors associated with increasing or maintaining the number of network members (alters) participants used cannabis with before and during the pandemic. Multilevel modeling identified ego- and alter-level factors associated with dyadic cannabis use between each ego and alter during the pandemic. Results. Most participants (61%) decreased the number of alters they used cannabis with, 14% maintained, and 25% increased. Larger networks were associated with a lower risk of increasing (vs. decreasing); more supportive cannabis-using alters was associated with a lower risk of maintaining (vs. decreasing); relationship duration was associated with a greater risk of maintaining and increasing (vs. decreasing). During the COVID-19 pandemic (August 2020 – August 2021), participants were more likely to use cannabis with alters they also used alcohol with and alters who were perceived to have more positive attitudes towards cannabis. Conclusions. The present study identifies significant factors associated with changes in young adults’ social cannabis use following pandemic-related social distancing. These findings may inform social network interventions for young adults who use cannabis with their network members amid such social restrictions.
ARTOSVITA FOR CHILDREN OF EARLY AGE: ASPECTS OF PEDAGOGICAL SUPPORT
Authors: Polovina О. , Kondratets I.
Published: February 2023

The article is devoted to the issue of the art world of young children at the current stage of preschool education development. Scientific research that solves the problems of the development of young children and the implementation of psychological and pedagogical support for various types of artistic and creative activities of children of the specified category has been analyzed. The theoretical foundations of the art world of young children are substantiated. The specifics and potential of the art world are revealed: a guide to the beauty and properties of sound, color, material, examination of materials and their properties, experience of manipulative actions, awakening of an emotional response to works of art. The positions on which educational interaction with young children should be built are outlined: the development of interest in knowledge, activity, curiosity of the child, hisopennesstocooperationandcommunication, initiative, readiness forexperimentation, self-testing

The peculiarities of artistic and creative types of activities of young children are characterized, namely, artistic- productive, musical, theatrical. Aspects of psychological and pedagogical support of the art world of young children are highlighted: 1) orientation to the aesthetic perception of the environment and the feeling of beauty in the environment; 2) motivation of children for research and artistic activity; 3) providing freedom of choice and independence in acquiring experience of actions with various materials; 4) development of children’s volitional sphere and desire to get results; 5) laying the foundations of emotional, sensory and empathic culture of young children; 6) supporting the initiative and personal potential of each child; 7) a sense of the natural rhythms, needs and aspirations of a young child. In the context of the topic, specific situations that help teachers to ensure the effectiveness of interaction with young children are considered. The constructive experience of providing psychological and pedagogical support to the art world of young children has been updated.
REALITIES OF INNOVATION IN THE DEVELOPMENT OF HIGHER PEDAGOGICAL EDUCATION, OR WHEN THE INTERNET DISAPPEARS
Authors: Leontieva I.
Published: February 2023

The article attempts to explore and highlight the peculiarities of innovative development of higher pedagogical education in Ukraine at the present stage, to outline the possible “modernization” risks of such progress. The relevance of the chosen topic is due, on the one hand, to the fact that innovation in education is a requirement of the time, on the other hand, the sphere of innovation is extremely complex and multifaceted, so it is quite difficult to study and predict. The following theoretical methods were used for the study: systematic analysis of researches of domestic scientists on the problems of innovative development of society and education, meta-analysis of applied research; structural and logical analysis of the studied processes. Five main featuresof the development of higher pedagogical education and related “modernization risks” were outlined the first two key features of the innovative development of higher education in Ukraine: formalization and regulation of innovative activities in the field of education («top-down» position) and the rapid accumulation of scattered empirical data on certain aspects of innovation in education; the third feature of innovative development of higher pedagogical education in Ukraine is the dominance of empirical findings on certain innovative aspects with low productivity of innovative solutions. Higher education in the information society really needs innovations and can no longer be imagined without digital technologies, but, in our opinion, there is a phenomenon of certain identification and sometimes substitution of the concepts of «innovation» and «digitalization». This is the fourth feature of the innovative development of higher pedagogical education in Ukraine. The last (fifth) feature of the innovative development of higher pedagogical education that we have identified is closely related to the concept of «digital divide»
Aprendizagem da docência para a educação superior em um contexto de pandemia
Authors: Sousa Raylson Francisco Nunes de , Gurgel Iure Coutre , Castro Francisco Mirtiel Frankson Moura
Published: February 2023

Este artigo analisa como as experiências e as aprendizagens constituídas durante o Estágio de Docência contribuem para a formação pedagógica do futuro professor com vistas ao exercício do magistério na Educação Superior. Realizada em 2022 em um Programa de Pós-graduação em Educação, a pesquisa de abordagem qualitativa foi consolidada por meio de fundamentação teórica e em narrativas de experiências. As aprendizagens e as experiências constituídas quando da realização do Estágio de Docência concorrem, em destaque, para a formação pedagógica e a apropriação de conhecimentos sobre a docência na Educação Superior, principalmente em um contexto desafiador de ensino remoto na pandemia da covid-19.
Simulación de curvas de rompimiento con un modelo fenomenológico para describir la adsorción de Cu (II) y de Pb (II) en columna empacada de lecho fijo empleando isotermas de adsorción de Langmuir, Freundlich y Redlich - Peterson
Authors: González J. Botello , Guzmán N.E Dávila , No- Córdova F. J. Ceri
Published: February 2023

Los metales pesados como el cobre y plomo son fuente de contaminación de forma natural y antropogénica y son considerados tóxicos a concentraciones superiores a los límites tolerables por el ser humano y representan un peligro para la salud dada sus características de acumulación, no biodegradabilidad y toxicidad. Las aportaciones del presente trabajo será la simulación gráfica en tres dimensiones para describir el proceso de adsorción dinámica en columna empacada con residuos sólidos sustentables de café modificados químicamente con ácido cítrico 0.6 M para la remoción de Cu (II) y Pb (II) resolviendo un modelo fenomenológico matemático considerando dispersión axial y adsorción en equilibrio basada en los modelos de isotermas de adsorción de Langmuir, Freundlich y Redlich - Peterson. Las gráficas obtenidas muestran concordancia con los resultados de mejor ajuste obtenidos en un estudio previo en lote entre los modelos estudiados, los cuales, se verifica con los coeficientes de regresión de cada uno de ellos; si sus coeficientes son similares, sus superficies también lo son.
Kajian Yuridis Terhadap Klausula Baku Barang Yang Sudah Di Beli Tidak Dapat Ditukar Kembali Menurut Undang-Undang Nomor 8 Tahun 1999
Authors: Achmad Salmin , Saleh Moh.
Published: February 2023

Tujuan penelitian ini untuk mengetahui pengaturan klausula baku dalam Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen dan untuk mengetahui bentuk tanggung jawab pelaku usaha karena menerapkan klausula baku barang yang sudah dibeli tidak dapat ditukar kembali yang merugikan konsumen. Jenis penelitian yang digunakan jenis penelitian normatif dan menggunakan metode pendekatan perundang-undangan, pendekatan konseptual, dan pendekatan kasus. Berdasarkan hasil penelitian menunjukkan bahwa aturan pencantuman klausula baku yang benar diatur dalam Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen dan pertanggung jawaban pelaku usaha yang melanggar ketentuan Undang-Undang Nomor 8 Tahun 1999 Tentang Perlindungan Konsumen dalam mencantumkan klausula baku dikenakan sanksi ganti rugi akibat perbuatan melawan hukum sesuai dengan Pasal 1365 KUHPerdata, selain tanggung jawab perdata pelaku usaha juga dimintai tanggung jawaba secara pidana sesuai Pasal 62 ayat (1) dan Pasal 383 KUHP.
Analisis Tanggung Jawab Direksi Perusahaan Terhadap Wanprestasi Kaitannya Dengan Prinsip Piercing The Corporate Veil
Authors: Kirana Nitia Nanda , Fitrahady Khairus Febryan
Published: February 2023

Tujuan penelitian ini adalah untuk mengkaji apakah direksi perusahaan bertanggung jawab secara pribadi atas wanprestasi dan kaitannya dengan prinsip piercing the corporate veil serta bagaimana pertimbangan hakim dalam menjatuhkan putusan dan menerapkan prinsip piercing the corporate veil dalam beberapa putusan. Metode penelitian yang digunakan adalah metode penelitian normatif. Berdasarkan hasil penelitian bahwa, pertama direksi dapat bertanggung jawab secara pribadi jika melakukan wanprestasi yang disebabkan oleh kelalaian direksi dan jika perbuatan tersebut merugikan perusahaan secara langsung. Kedua, hakim memberikan pertimbangan untuk memutus direksi bertanggung jawab secara pribadi apabila direksi telah wanprestasi disebabkan karena kelalaian direksi dan dianggap melanggar Pasal 3 UUPT.
Conducting Grounded Theory Research in the Early Days of the Coronavirus Pandemic: Process Interruptions, Barriers, and Innovative Approaches to Study Design
Authors: Corr Patrick G. , Davidson Leslie F.
Published: February 2023

The COVID-19 pandemic changed the ways by which qualitative research is designed, participants are recruited and engaged, and results are shared regardless of research disciplines or epistemological perspectives. As a result of on-going requirements for social distancing and remote working or learning, researchers have had to redefine effective research methods by reimaging recruitment and data collection, investing in VoIP technology, and developing innovative ways to build trust across digital platforms. This manuscript explores how one Grounded Theory research study evolved in response to the emergence of COVID-19 and presents recommendations for innovative approaches to study design, data collection, and continuous participant interaction. We also briefly discuss ethical considerations that have emerged over the past two years.
Media geométrica. Contando bichos.
Authors: Manuel Molina
Published: February 2023

La media geométrica se utiliza cuando los valores de la distribución de datos cambian de forma multiplicativa, y no aditiva. Esto la hace ideal para promediar datos de progresión geométrica, como razones, interés compuesto en economía o crecimientos de bacterias en microbiología.
Processes on the glass surface under irradiation with medium-energy electrons
Authors:   JSC “Kompozit”, Khasanshin R. H. ,   Bauman Moscow State Technical University, Novikov L. S. ,   D.V. Skobeltsyn Research Institute of Nuclear Physics, Lomonosov Moscow State University
Published: February 2023

The results of experimental studies of the processes occurring on the surface of protective glasses of solar batteries and elements of reflective coatings of high-orbit artificial Earth satellites (AES) under irradiation with electrons with an energy of 30 keV are presented. The studied samples were made on the basis of K-208 glass, while the samples of reflective coatings differed in the presence of silver and stainless steel layers on the reverse surface of the glass plates, deposited sequentially by the magnetron sputtering method. Electron irradiation of the samples was carried out in a vacuum of 10–4 Pa at a particle flux density (φ) from 1·109 to 8·1012 cm–2s–1; the surfaces of the samples before and after irradiation were examined by atomic force microscopy (AFM). On the irradiated surface of glass samples, electrostatic discharges (ESD) arose, the parameters of which were characterized by oscillograms of generated electromagnetic pulses; for elements of reflective coatings, leakage currents to the metal substrate were additionally measured. It was found that changes in the structure of the irradiated surface of the samples are due to the appearance of traces of ESD and the formation of gas-filled bubbles on it, and changes in the back surface of glass plates are caused, presumably, by shock waves formed when ESD occurs on the irradiated surface. The ESD frequency and leakage currents increase with increasing electron flux density in the specified range, but these dependences differ significantly. Measurements at a constant value of φ = 2.0·1010 cm–2s–1 showed that with an increase in the electron fluence from 1014 to 5·1016 cm–2, the ESR frequency increases, but the amplitude of electromagnetic pulses decreases.