bluuebunny/crossref_metadata_2025 huggingface dataset:
PENYULUHAN PEMANFAATAN LAHAN PEKARANGAN WARGA DESA CIKARAGEMAN BEKASI SOLUSI TEPAT PENERAPAN STRATEGI GREEN MARKETING USAHA LELE DITENGAH PENDEMI COVID-19
Authors: Hasibuan Ahmad Nurdin , Aras Marsadi , Suharli Oktofiani , Hermasari Noor Oktavia , Syahrul Muhammad
Published: June 2022

Desa Cikarageman, Bekasi merupakan salah satu desa yang memanfaatkan pekarangan rumah untuk budidaya ikan lele. Desa Cikarageman Bekasi menjadi salah satu mitra IBI Kosgoro 1957 untuk mengembangkan kegiatan masyarakat untuk meningkatkan taraf hidup di masa pandemi. Usaha budidaya lele yang sudah berjalan ini harus dikelola dengan green marketing agar dapat berjalan dengan baik dan dapat diterima oleh semua kalangan. Upaya ini baik dilakukan pada setiap siklus panen, namun dalam beberapa bulan terakhir produksi belum sesuai dengan hasil yang diharapkan. Ketidaksesuaian tersebut disebabkan oleh rendahnya pemahaman masyarakat desa tentang budidaya ikan lele dengan tong di sekitar rumah, dan nilai jual yang masih rendah karena salah paham dalam meningkatkan nilai tambah ikan lele. Program kemitraan yang telah terbentuk diharapkan mampu menerapkan green marketing sehingga dapat berkelanjutan setiap tahunnya.
Recommendations for the modulation index choice of UWB radio systems with BPPM in indoor channels
Authors: Karbolin V. A. , Nosov V. I.
Published: June 2022

The impact of modulation index on the BER performance of BPPM in UWB radio is analyzed in multipath indoor channels. The recommendations for the optimal modulation index choice are drawn up with respect to minimum bit error rate in multipath indoor channel. The theoretical expression for BER performance of BPPM is derived. The BER performance figures for different data rates as a function of a signal to a noise ratio produced by using the theoretical expression and computer simulations are presented. MATLAB is used for computer simulations.
Researching the behavior of variables relative contributions to the total determination in regression equation estimated using the method of distorted coefficients straightening
Authors: Bazilevskiy M. P.
Published: June 2022

To solve the problem of multicollinearity in regression analysis a distorted coefficients straightening method developed by the author and based on the construction of fully connected linear regression model can be used. In the article, to assess the degree of independent variables influence on the dependent variable in the regression equation obtained by using this method, it is proposed to use the variables relative contributions to the total determination. It is proved that in such an equation in the case of linear functional dependence of the input variables their relative contributions to the total determination are equal. Then, with a strong correlation of the input variables, their contributions are distributed approximately in the same way. It is proved that the problem of estimating a fully connected regression does not depend on the choice of connecting variable. The obtained results have been successfully demonstrated using the example of the Russia's GDP modeling.
Plant Defense Proteins
Authors: Chakraborty Biswanath
Published: June 2022

Plants are compelled to withstand stresses of all kinds, be it biotic, abiotic or anthropogenic as a consequence of their immobility. The initial infection process involving adhesion/recognition events between plants and fungal pathogens is essential for the establishment of pathogenesis. The extracellular matrix (ECM) is a biologically active part of the cell surface composed of a complex mixture of macromolecules that, in addition to serving a structural function, profoundly affect the cellular physiology of the organism. During the past two decades it has become evident that the cell wall is a dynamic organization that is essential for cell division, enlargement and differentiation as well as responding to biotic and abiotic stress. ECM is also the source of signals for cell recognition within the same or between different organisms. Cell walls are natural composite structures, mostly made up of high molecular weight polysaccharides, proteins and lignins. Lignins are only found in specific cell types. Arabidopsis thaliana cell wall proteins (CWP) that can be involved in modifications of cell wall components, wall structure and signaling as well as interactions with plasma membrane proteins at the cell surface has been reviewed.
Anthrax and Bioterrorism
Authors: Chowdhury J , Sen Arnab
Published: June 2022

Bioterrorism is the deliberate discharge or dissemination of viruses, bacteria, or other germs used to cause sickness or death in people, animals, or plants. Though these agents are found in nature they are usually modified to increase their ability to cause disease, make them resistant to current antibiotics, or to increase their ability to be spread into the environment. Biological agents can be spread through the air, through water, or in food. Terrorists may use biological agents because they can be extremely difficult to detect and do not cause illness for several hours to several days. Among these biological agents, Anthrax is considered to be the Category-A agent because of its high potency for adverse public health impact and serious effect on large-scale dissemination. Though there is a big hue and cry in the recent past about bioterrorism particularly after 9/11 attack, the history of bioterrorism is fairly old. In the present paper, we have sketched the history and the evolution of bioterrorism with reference to anthrax, particularly microbiology and pathogenesis of the disease causing agent and its clinical symptoms and treatments.
IMPLEMENTASI EXPRESS JS UNTUK MEMBANGUN REST API WEBSITE STIKOM PGRI BANYUWANGI
Authors: Clinton Hatta Pradigi  , Tintin Harlina  , Solehatin
Published: June 2022

Website STIKOM PGRI BANYUWANGI adalah website informasi yang membantu perguruan tinggi tersebut dalam memberikan informasi terhadap calon mahasiswa baru maupun mahasiswa yang sudah terdaftar tentang jalur pendaftaran bagi mahasiswa baru, informasi - informasi kegiatan, fasilitas kampus, dan hal lain yang bersangkutan dengan STIKOM PGRI BANYUWANGI. Dimana sekarang teknologi Informasi berkembang semakin pesat dari waktu ke waktu maka dibutuhkan pengembangan untuk moderenisasi website. Dari permasalahan tersebut maka digunakan Express JS untuk membangun REST API sebagai penjembatan antara front-end dan back-end guna meningkatkan kinerja dan moderenisasi website tersebut. Karena Express JS memudahkan  dalam  pengelolaan model, tampilan, dan kontroler. Selain itu Express JS juga mempunyai skalabilitas aplikasi yang baik dan memiliki fitur caching dimana kita tidak harus mengeksekusi kode terus - menerus sehingga halaman web dapat memuat lebih cepat dan dapat berpengaruh terhadap sisi performa dari aplikasi yang dibuat. Dari hasil penelitian implementasi Express JS untuk membangun rest api ini diharapkan dapat membantu meningkatkan kinerja dan moderenisasi website STIKOM PGRI Banyuwangi
Somos um imenso bordado de nós: experiências escolares que escapam dos modelos cisheteronormativos
Authors: Ferreira Jucélia Pinto , De Souza Ana Paula Abrahamian , Botelho Denise Maria
Published: June 2022

Esse estudo tem o objetivo de problematizar as experiências escolares de cinco estudantes que escapam dos modelos cisheteronormativos de gênero e sexualidade. Utilizamos como aporte teórico-metodológico as contribuições dos estudos feministas, dos estudos gays e da Teoria Queer, centrando a aproximação com esses campos numa perspectiva pós-estruturalista. A presente investigação contou com a abordagem qualitativa e os dados foram construídos a partir da entrevista narrativa e do caderno de memórias. É possível dizer que na educação infantil e no ensino fundamental as experiências escolares das/os protagonistas dessa pesquisa se constroem a partir de referenciais negativos que as/os colocam em posições de subalternidade. Com a chegada do ensino médio, essas/es estudantes conseguiram se conectar com histórias, espaços e narrativas que produzem formas de inteligibilidade para seus grupos de pertença, ao passo que reafirmam e ressignificam suas identidades.
Materiały do rozmieszczenia porostów i grzybów naporostowych Polski, 2
Authors: Kossowska Maria , Krzewicka Beata , Kościelniak Robert , Kukwa Martin , Kowalewska Agnieszka , Szymczyk Rafał , Smoczyk Michał , Markiewicz Kamila , Adamski Marek
Published: June 2022

Streszczenie

W publikacji przedstawiono nowe stanowiska 39 gatunków porostów oraz 10 grzybów naporostowych (te ostatnie oznaczono gwiazdką), które są zagrożone w Polsce lub rzadkie w kraju lub regionie.Didymocyrtis epiphyscias. l. jest podawany poraz pierwszy z obszaru Polski. W zamieszczonych wykazach stanowisk, obok współrzędnych geograficznych, podano kwadraty siatki ATPOL, zmodyfikowanej na potrzebyAtlasu rozmieszczenia geograficznego porostów w Polsce(wydawnictwo Instytutu Botaniki im. W. Szafera PAN, 1993) przez Cieślińskiego i Fałtynowicza. Poza wykazem stanowisk, przy każdym z gatunków zamieszczono dane na temat ich cech diagnostycznych oraz rozmieszczenia w Polsce.
Skaldinnans rörelser på fältet
Authors: Lilja Eva
Published: June 2022

The poet Elsa Grave had lier public breakthrough with the collection Bortförklaring 194<S. This arlicle interprets her success in terms of Bourdieu s sociology of culture. His concept "synibolic capital" is proved usefnl for women studies. It helps in analysing how different vallies are applied to men and women. The concept of habitus is also found useful as it concentrates on the body as a social construction. The field-concept, however, might - wrongly used - easily t um into a trap. It focuses onlv public life and can thereby serve to hide vvomens reality and practice. It has to be used carefully. Grave is not a typical actor in the literary fteld. She manages to get into the avant garde position twice with a couple of years in between. She had a good symbolic capital in her university education, but in the long run she could better use her experience as a mother. Grave broke the tradition of pathetic women poets when she turnd into a grotesque style of writing. In her public image she represented the selfsufficient mother rather than the inspired muse. With her new and different habitus she introduced and broke new ways for women poets that followed.
I Skyddsängelns gränsland
Authors: Hällgren Anneli , Nilsson Ingrid
Published: June 2022

I traditionell film går berättandet patriarkatets ärenden menar forskaren Teresa de Lauretis. För att fä svar på frågan varför kvinnor ändå roas av att se sådan film, studerar hon berättelser i området där semiotik och psykoanalys överlappar varandra. Kvinnor förförs genom dubbel identifikation, menar hon. Men går det inte att i berättelser direkt rikta sig till kvinnliga åskådar subjekt ? Med hjälp av hennes teorier ser vi filmen Skyddsängeln med nya ögon.
Ensidig fokusering på särart istället för jämställdhet
Authors: Wikander Ulla
Published: June 2022

En central broschyr om skolans jämställdhetspolitik har ensidigt tagit fasta på könsskillnaden. För jämställdheten i skolan innebär det ett stort steg bakåt om kön blir en organiserande princip, oavsett individuella läggningar och prestationer.
Transfer, Contract and Work Relations in Esports: A Qualitative Research on the Game League of Legends
Authors: AYDIN Yusuf , ŞAŞMAZ ATAÇOCUĞU Muazzez
Published: June 2022

The aim of this study was to reveal the transfer processes, contracts and labor capital, relations, and working conditions of esports players within the electronic sports sector in Turkey. The findings obtained, it was aimed to identify the deficiencies in the esports industry and contribute to this field. Our study was designed according to the qualitative method and the semi-structured interview technique was used. Interviews were held online via Discord and Whatsapp in February 2021 and August 2021. The sample group of the study consisted of 13 participants who have retired or continue to wear uniforms in esports clubs. As a result of the findings obtained; there was no intermediary in the transfer process, the transfer process varied depending on the career of the player, esports players did not have information about social security, career times were shorter than in traditional sports, esports players were worried about the future, working hours were flexible, and there were some disputes between the esports players and esports teams. The results have been determined, such as the tendency of esports players to seek their rights on social media.
Ethical Decision Making in Soft lifting-A UAE Based Case Study
Authors: Mago Dr. Beenu , Abdullahi Aideed Amira , Salim Al Ali Hassan , Saeed Alnuaimi Sultan , Rashid Al Qahtani Fahad
Published: June 2022

Soft lifting is a type of software piracy that is prevalent in today's computer-dependent world. Soft lifting is a type of software piracy in which software is installed or duplicated in a system in violation of its license agreement. In software development, ethical decisions are critical, as they have a significant impact on end users, organizations, and the environment. As the problem of copying affects soft lifting behaviour, the research lends some credence to the postulates model. Most notably, the study found that one's ethical perspective of soft lifting has no bearing on one's softlifting activity. These findings have significant implications for both software companies and academics who are aiming to prevent piracy through ethics education.
The costs of road accidents in Poland
Authors: Krupińska Agnieszka
Published: June 2022

The article describes the problem of road accidents in statistical terms. The costs of road accidents were presented in a measurable and non-measurable context. Total and unit costs have been discussed.
APLIKASI KECANTIKAN DAN PERAWATAN WAJAH BERBASIS WEBSITE
Authors: Devi Indriani
Published: June 2022

Tujuan Penelitian ini untuk membuat Aplikasi yang memudahkan para wanita untuk mendapatkan informasi tentang Kesehatan kulit dan rekomendasi produk yang sesuai dengan jenis kulit maupun permasalahan kulit. website  katering ibu Ermina menggunakan php dan mysql yang diharapkan dapat  memberikan informasi pemesanan makanan – makanan katering secara Online kepada  pelanggan. Aplikasi ini menggunakan metode System Development Life Cycle (SDLC) dan Struktur navigasi digunakan sebagai alur dari suatu program yang menggambarkan rancangan yang dihubungkan dengan halaman lain melibatkan situs web. UML digunakan untuk merepresentasikan alur proses dari rangkaian pembuatan aplikasi ini. Hasil penelitian ini adalah dapat bermanfaat bagi pengguna serta informasi yang disediakan mudah dan  lebih dikenal oleh masyarakat karena mampu memenuhi kebutuhan para pelanggan yang sedang mencari produk Kesehatan kulit yang sesuai dengan jenis kulit maupun permasalahan kulit dari pelanggan.
Una visión sobre el emprendimiento en jóvenes universitarios: el caso de la Facultad de Ciencias Económicas Administrativas de la Universidad Autónoma del Carmen
Authors: Sulú Nancy Verónica Sánchez , Fernández Alberto Pérez , Hernández Luis Fernando Pulido
Published: June 2022

El crecimiento económico de los países implica la modificación de procesos productivos considerando la innovación. Este proceso innovador requiere de emprendedores que modifiquen bienes y servicios conforme la sociedad lo requiere y lo acepta. Esta investigación tiene por objetivo determinar las características que los alumnos de la Facultad de Ciencias Económicas- Administrativas de la Universidad Autónoma del Carmen consideran debe tener un emprendedor, además de las causas que ellos consideran limitan el emprendimiento. 93 % de los jóvenes entrevistados consideran importante recibir educación referente al emprendimiento para el desarrollo profesional, pero solo el 63 % mencionan que la educación de emprendimiento ayuda a determinar el futuro del joven universitario; y es que solo 33 % de los jóvenes consideran que el emprendedor exitoso requiere de estudios de nivel superior. 76 jóvenes iniciaron un negocio y de los cuales 27 mantenían el negocio en funcionamiento. Las tres causas principales por la que no se inician negocios es por falta de financiamiento, falta de experiencia para iniciar un negocio y miedo a fracasar en el negocio.
Penerapan Keterampilan Proses Dasar Berbasis Lingkungan Untuk Meningkatkan Hasil Belajar Siswa
Authors: Tyera Losicha , Megawati Merty , Rusli Mulyadi
Published: June 2022

Tujuan penelitian Perbaikan Pembelajaran ini untuk meningkatkan aktivitas dan hasil belajar Pembelajaran matematika dengan penerapan pendekatan keterampilan proses dasar berbasis lingkungan kelas VI SDN 156/III Tangil   Kabupaten Kerinci. Subjek penelitian ini adalah siswa kelas VI SDN 156/III Tangil   Kabupaten Kerinci berjumlah 16 orang Siswa. Prosedur penelitian tindakan kelas yang dilakukan oleh peneliti berdasarkan model PTK yaitu kemmis dan Mc Taggart yang terdiri dari kegiatan perencanaan, pelaksanaan, observasi dan evaluasi. Penelitian ini dilaksanakan sebanyak 2 siklus dengan masing-masing siklus sebanyak 2 pertemuan. Pada siklus I aktivitas siswa diperoleh dengan rata-rata secara klasikal 62,93% yang termasuk dalam kualifikasi Baik. Pada siklus 2 aktivitas siswa mengalami peningkatan dengan rata-rata persentase aktivitas siswa 71,16% dengan kualifikasi baik. Artinya terdapat peningkatan 6,23%. Hasil belajar siswa pada siklus 1 dengan rata-rata yang diperoleh 60,00 dengan kualifikasi cukup baik dan meningkat pada siklus 2 dengan rata-rata yang diperoleh 81,94 dengan kualifikasi Baik. Artinya terdapat peningkatan sebanyak 21,94. Berdasarkan hasil penelitian dapat disimpulkan bahwa penerapan pendekatan keterampilan proses dasar berbasis lingkungan dapat meningkatkan aktivitas dan hasil belajar pembelajaran matematika kelas VI SDN 156/III Tangil Kabupaten Kerinci.
Analysis Of Job Burden Using Method of FTE (Full Time Equivalent) at Puskesmas Pantoloan
Authors: Ayudina Yenita , Sudirman Sudirman , Nurjanah Nurjanah
Published: June 2022

Health development is an integral and important part of national development. The objective of implementing health development is to increase awareness, willingness, and ability to be alive healthy for everybody to create a degree of optimal public health. The advance of health development is not absent from health staffs in it, competent health staff s in their fields and an appropriate number of staffs at every facility of service decided given service quality. To meet the number of staff e appropriately with the demand of health service facilities. job burden analysis is carried out. There are some methods used to do job burden analysis. In this research, the researcher used the method of FTE (Full Time Equivalent) to carry out an analysis of job burden. This research used a descriptive with a qualitative approach, conducting observation, deep interview, and documentation. The informant of this research is ane staff whole plays role as the manager of ABK  data (analysis of job burden) at Puskesmas Pantoloan. Research findings show that the computation result of job burden analysis that used method of Full-Time Equivalent (FTE) job burden of health staffs at Puskesmas Pontoloan is overload category because FTE index which is obtained is 2,7. The conclusion of research findings shows that computation result of job burden analysis that used Full-Time Equivalent (FTE) show that job burden of nine kinds of health staffs at Puskesmas Pantoloan include overload category with FTE index 2,7 indicated that the number of health staffs is less than job burden accepted by health staff.
The Correlation Between Knowledge and Attitude About Covid-19 with Compliance with the use of Masks at Masombamarket
Authors: Nurhidaya Nurhidaya , Afni Nur , Nurjanah Nurjanah
Published: June 2022

Non-compliance with the application of health protocols can expand the spread of COVID-19, particularly in public places such as markets. In preoobservations at Masomba market, a small number had used masks properly, but some wore marks on their necks, and many of them did not use masks when trading. The purpose of this research is to determine the correlation between knowledge and attitude about COVID-19 with compliance with the use of masks at the Masomba market. This is quantitative research with a cross-sectional approach using the Chi-Square test and an alpha value = 0,05. The sample of this research is 83 respondents. The independent variables are knowledge and attitudes, and the dependent variable is compliance with the use of masks. The results of this research indicate that the value (p-value) = 0,003 ≤ 0,05 then Ho is rejected, which means that there is a correlation between knowledge of COVID-19 and compliance to the use of masks and the p-value = 0,019 ≤ 0,05 then Ho is rejected which means there is a correlation between attitude and compliance with the use of masks. Good knowledge and attitude of traders about COVID-19 can reduce the risk of COVID-19 transmission, which is supported by disciplined health protocols, especially obedience to using masks in public places, and if there are traders who do not comply with mask use, they can be given a warning both verbally and in writing and appropriate sanctions.
Channel Analysis and Marketing Margin of Instant Ginger Powder in Mpanau Village, Sigi Biromaru District, Sigi Regency
Authors: Endah Wahyunuing Asih
Published: June 2022

Dahlia Farmers Group has been engaged in the traditional instant powder drink industry, namely ginger. Of the various kinds of health drinks that this farmer group has produced, instant drink products are made from ginger, increasing sales every year. Currently, the Dahlia Farmers Group still has limitations in carrying out activities related to product marketing. This limitation impacts the lack of knowledge of producers regarding the marketing of instant red ginger powder. There are 3 (three) channels occur in the instant marketing of ginger powder in Mpanau Village, Sigi Biromaru District, Sigi Regency: Channel I: Producer Trader Consumer Retailer, Channel II: Consumer Online Producer, Channel III: Consumer Producer. Margin obtained from these three channels: First channel I: The margin earned in this channel is Rp.25,000,-/pack, Channel II: The margin obtained in this channel is Rp.15,000,-/pack. Channel III: Margin earned in this channel is Rp. 0,/pack. The Total Marketing Margin obtained in these three channels is Rp. 40,000.
The Role of Leadership on Sustainable Improvement in Improving Product Quality in the Division of PT. North Sumatra Coal Inalum
Authors: Kholilul Kholik  , Iman Sudirman  , Yusuf Arifin
Published: June 2022

Leaders in organizations including company managers who have a goal to increase production and efficiency in order to maximize results for the organization they lead. A leader must be able to bring the organization or company and all its employees with a clear vision. Only with a clear vision, concepts and organizational goals can be described properly, but leaders must also be able to mobilize all resources within the company to move together and work together to achieve goals effectively. Leaders must have a clear vision in building and developing a business, especially those related to product quality improvement. A clear vision and mission of the company and implemented together is the key to the company's success to compete in the business world, such as PT. Inalum Coal North Sumatra which produces quality products and is able to compete in the world. The objectives of this study are 1) to determine the role of leadership in continuous improvement and its implications for the quality of the product division of PT. North Sumatra Coal Inalum; 2) to determine the factors that affect the improvement of product quality in the Division of PT. North Sumatra Coal Inalum. This research is a case study which was analyzed with a qualitative approach. This research shows that the role of leadership is very large in making continuous improvements so as to produce quality products that can compete in the business world on a national and international scale.
Experiência do cliente com cateter venoso central de inserção periférica (PICC)
Authors: Machado Juliana Pereira , Rodrigues Carolina Barbosa Costa , Silva Cássia Carolina da Costa , Santos Rouver Henrique Gouvêa dos
Published: June 2022

O cateter venoso Peripherally Inserted Central Venous Catheter (PICC), é inserido por punção venosa superficial ou profunda, geralmente nos membros superiores, até a veia cava, o que lhe confere funções de cateter central. Ao redor do mundo, tem sido atribuído ao enfermeiro o procedimento de inserção. Até o momento, pouco se sabe sobre experiências dos clientes com PICC. O objetivo foi identificar, na literatura científica, a experiência do cliente com relação ao uso do PICC. Revisão integrativa, realizada na base de dados EBSCO, de artigos publicados nos últimos 10 anos, em inglês ou português, cujo tema central fosse a experiência de pacientes com uso de PICC. A amostra conta com 6 artigos, sendo 1 de 2014, 1 de 2016, 3 de 2017 e 1 de 2019, com autores enfermeiros, médicos e psicólogos, oriundos dos Estados Unidos, Austrália, Inglaterra e Coreia do Sul. As principais experiências relatadas versam sobre alívio pela interrupção de múltiplas punções e liberdade de movimentos que o dispositivo proporciona. Das experiências com conotação negativa, os artigos falam de trombose venosa, medo, dor, vergonha, dificuldades para o banho, para realizar atividades de vida diária e a falta de conhecimento dos profissionais para manusear o dispositivo. Todos os artigos desta revisão possuem baixa força de evidência. Ressalta-se a necessidade de educação continuada nas unidades hospitalares direcionadas à orientação permanente e envolvimento dos clientes em seu cuidado, desde a toma da de decisão baseada em riscos e benefícios, a fim de melhorar suas experiências com o cateter PICC.
Wahrheitsdetektionssysteme mit künstlicher Intelligenz
Authors: Trentmann Christian H. W.
Published: June 2022

The book deals with lie detection systems based on artificial intelligence (AI) in the context of white-collar crime, internal investigations, and legal tech. It is an impressive technical and legal assessment of the status quo of “lie detection 2.0” yet unique in research and practice.

Christian H. W. Trentmann worked at the University of Tuebingen and is a lawyer in Hamburg with a focus on the practice area Technology, Media & Telecoms (TMT). His special expertise is in the field of the digitalisation of law (legal tech) as well as national and European criminal law and criminal procedure law, especially IT criminal law (cybercrime).
Association of Helicobacter pylori Infection with Papillary Thyroid Carcinoma: A Case-control Study
Authors: Bakhshipour Alireza , Amirian Maryam , Heidari Zahra
Published: June 2022

Background: The thyroid nodules incidence has risen worldwide. Although factors such as increasing the use of imaging techniques and more rapid detection of small thyroid nodules have been implicated in the recent rise in thyroid cancer incidence, some environmental parameters such as infectious agents may be involved. Helicobacter pylori infection is an environmental risk factor, which may mimic the antigenic properties of membranes of thyrocytes. Objectives: This study aimed at evaluating the association of H. pylori infection with benign and malignant thyroid nodules in comparison with the control group. Methods: Patients with benign thyroid nodules, papillary thyroid cancer (PTC), and euthyroid healthy controls without thyroid nodules that had just been diagnosed were included in the study. All participants underwent clinical examination. Various biochemical parameters such as serum H. pylori Ab (IgG) and thyroid function tests were measured. Comparisons were made between groups. Results: Finally, 370 patients with benign thyroid nodules, 364 patients with PTC, and 360 healthy subjects without nodules participated as a control group. In the patients with PTC, the prevalence of H. pylori infection was 89.6%, while in the group of patients with benign thyroid nodules and the control group was 81.1% and 75%, respectively (P < 0.001). Helicobacter pylori antibody (Ab) titer was not significantly associated with any of the anthropometric and biochemical variables. Conclusions: Helicobacter pylori infection was significantly higher in patients with benign thyroid nodules and PTC than in the control group. Also, the rate of infection was significantly higher in the malignant nodule group than in the benign thyroid nodules group.
Gut Microbial Profile in Patients with Pancreatic Cancer
Authors: Wang Xue-Yuan , Sun Zao-Xi , Makale Emmanuel Costantine , Sun Zheng-Ke , Wang Tai-Cheng , Hou Zhi-Ying , Yu Xing-Yue , Long Wenfang , Du Guan-Kui , Huang Hairong
Published: June 2022

Background: Pancreatic cancer is a lethal tumor with a poor prognosis. The connection between pancreatic cancer and gut microbiota is less reported. Objectives: This study analyzed microbial characteristics in patients with pancreatic cancer from the tropical area of China and explored the potential impact of the characteristic microflora on pancreatic cancer. Methods: Stool samples and blood test indices of participants were collected in Hainan, China. Metagenomic sequencing was used to analyze the gut microbiota characteristics. The R corrplot package was used to analyze the correlation between gut microbiota and blood test indices. Results: The microbial community in pancreatic cancer were clustered together and significantly separated from controls. The Simpson index was increased significantly in pancreatic cancer compared to controls. The abundances of butyrate-producing bacteria (Anaerostipes hadrus, Lachnoclostridium phocaeense, and Romboutsia ilealis), Bifidobacteria, and [Eubacterium] eligens were significantly decreased, while Fusobacterium, Enterobacter, and Enterococcus were significantly increased in pancreatic cancer. Prevotella copri may have a vital role in the bacterial interaction network. Pathways connected to metabolism, environment (bacterial secretion system), genetic information (protein export and ribosome), and human diseases (infectious diseases and drug resistance) were increased in the pancreatic cancer group. Butyrate-producing bacteria (butyrate-producing bacterium SS3/4, A. hadrus, R. intestinalis, and Faecalibacterium prausnitzii) and Bifidobacteria were significantly negatively correlated with the neutrophil-to-lymphocyte ratio. Conclusions: The gut microbiome was distinct in patients with pancreatic cancer from the tropical area of China. Changes in intestinal flora abundance and metabolic pathways may play an essential role in the occurrence and development of pancreatic cancer.
Median Arcuate Ligament Syndrome with Common Hepatic and Splenic Arteries Directly Originating from the Abdominal Aorta: A Case Report
Authors: Mehrnahad Mersad , Hasanian Mohammad , Mehrnahad Mohammad Mosahar
Published: June 2022

Introduction: Knowledge of the unpaired abdominal vasculature is important for uncomplicated operations. The absent celiac trunk has previously been reported; however, developmental alterations can result in a variety of branching patterns of the downstream arteries from the abdominal aorta. Case Presentation: A 53-year-old female patient with lymphoma underwent abdominopelvic computed tomography (CT) for staging. She had a history of postprandial off-and-on abdominal pain since her youth. CT scan revealed an absent celiac trunk with common hepatic and splenic arteries directly originating from the abdominal aorta. Compression of the median arcuate ligament had narrowed and angulated the 2 branches. Conclusions: When the celiac trunk is absent, its main branches may separately arise from the abdominal aorta. Also, due to the displacement of these branches, their path and diameter can vary from the normal.
Explainable Artificial Intelligence (XAI)
Authors: Ridley Michael
Published: June 2022

The field of explainable artificial intelligence (XAI) advances techniques, processes, and strategies that provide explanations for the predictions, recommendations, and decisions of opaque and complex machine learning systems. Increasingly academic libraries are providing library users with systems, services, and collections created and delivered by machine learning. Academic libraries should adopt XAI as a tool set to verify and validate these resources, and advocate for public policy regarding XAI that serves libraries, the academy, and the public interest.
”Det känns som att jag bara sitter och väntar på att det ska explodera” - politisk påverkan på de kommunala folkbibliotekens verksamhet i sex sydsvenska regioner.
Authors: Carlsson Hanna , Hanell Fredrik , Hansson Joacim
Published: June 2022

Public libraries are one of several institutions that uphold Swedish democracy. The representative liberal democratic model, expressed in the Library Act, is increasingly being questioned and challenged. Political actors, mainly from the radical right, advocate a democracy focused on the will of the people at the expense of the rights of individuals. With the notion of plural agonistics, public libraries can be seen as important arenas for debates and meetings between people, offering ways to handle conflicts within democratic institutions. Methodologically, this study employs the perspective of institutional ethnography, and the aim of this paper is to develop knowledge about public libraries’ experiences of political pressure and how this is enacted in a time of political turbulence. This paper reports findings from the first stage of a survey study directed at public library managers in 77 municipalities from the six southernmost regions of Sweden. Based on replies in these surveys, interviews were conducted with seven of the participating library managers. Findings show that the interplay between libraries and the local political level, and between national and local political levels, generally functions without notable opposition. Illegitimate political pressure is uncommon, but when it occurs, it is primarily triggered by issues connected to cultural diversity. Results further indicate that local public libraries tend to respond to illegitimate political pressure by development and use of professional policy documents, but also, in some cases, by avoiding certain activities.
Calculations of electron capture rates of 66Fe in astrophysical enviroment
Authors: Qing Wen-Tao , Zhi Qi-Jun , Yang You-Chang ,   School of Physics and Electronic Science, Guizhou Normal University, Guiyang 550001, China,   Guizhou Provincial Key Laboratory of Radio Astronomy and Data Processing, Guizhou Normal University, Guiyang 550001, China,   Guizhou University of Engineering Science, Bijie 551700, China,   Zunyi Normal University, Zunyi 563006, China
Published: June 2022

The calculation of weak interaction rates plays a very important role in studying nuclear physics and nuclear astrophysics. In this work, we calculate the electron capture rate of 66Fe in the framework of shell model. We mainly focus on the contribution of allowed transition and forbidden transition to the total rate. It is found that in some astrophysical environments the forbidden transition is very important in contribution to the electron capture rate, in which the non-unique forbidden transition plays a major role. This is very important for nuclear structures and astrophysics.
Projected resurgence of COVID-19 in the United States in July—December 2021 resulting from the increased transmissibility of the Delta variant and faltering vaccination
Authors: Truelove Shaun , Smith Claire P , Qin Michelle , Mullany Luke C , Borchering Rebecca K , Lessler Justin , Shea Katriona , Howerton Emily , Contamin Lucie , Levander John , Kerr Jessica , Hochheiser Harry , Kinsey Matt , Tallaksen Kate , Wilson Shelby , Shin Lauren , Rainwater-Lovett Kaitlin , Lemairtre Joseph C , Dent Juan , Kaminsky Joshua , Lee Elizabeth C , Perez-Saez Javier , Hill Alison , Karlen Dean , Chinazzi Matteo , Davis Jessica T , Mu Kunpeng , Xiong Xinyue , Pastore y Piontti Ana , Vespignani Alessandro , Srivastava Ajitesh , Porebski Przemyslaw , Venkatramanan Srinivasan , Adiga Aniruddha , Lewis Bryan , Klahn Brian , Outten Joseph , Orr Mark , Harrison Galen , Hurt Benjamin , Chen Jiangzhuo , Vullikanti Anil , Marathe Madhav , Hoops Stefan , Bhattacharya Parantapa , Machi Dustin , Chen Shi , Paul Rajib , Janies Daniel , Thill Jean-Claude , Galanti Marta , Yamana Teresa K , Pei Sen , Shaman Jeffrey L , Healy Jessica M , Slayton Rachel B , Biggerstaff Matthew , Johansson Michael A , Runge Michael C , Viboud Cecile
Published: June 2022

In Spring 2021, the highly transmissible SARS-CoV-2 Delta variant began to cause increases in cases, hospitalizations, and deaths in parts of the United States. At the time, with slowed vaccination uptake, this novel variant was expected to increase the risk of pandemic resurgence in the US in summer and fall 2021. As part of the COVID-19 Scenario Modeling Hub, an ensemble of nine mechanistic models produced 6-month scenario projections for July–December 2021 for the United States. These projections estimated substantial resurgences of COVID-19 across the US resulting from the more transmissible Delta variant, projected to occur across most of the US, coinciding with school and business reopening. The scenarios revealed that reaching higher vaccine coverage in July–December 2021 reduced the size and duration of the projected resurgence substantially, with the expected impacts was largely concentrated in a subset of states with lower vaccination coverage. Despite accurate projection of COVID-19 surges occurring and timing, the magnitude was substantially underestimated 2021 by the models compared with the of the reported cases, hospitalizations, and deaths occurring during July–December, highlighting the continued challenges to predict the evolving COVID-19 pandemic. Vaccination uptake remains critical to limiting transmission and disease, particularly in states with lower vaccination coverage. Higher vaccination goals at the onset of the surge of the new variant were estimated to avert over 1.5 million cases and 21,000 deaths, although may have had even greater impacts, considering the underestimated resurgence magnitude from the model.
Recurrent neural networks enable design of multifunctional synthetic human gut microbiome dynamics
Authors: Baranwal Mayank , Clark Ryan L , Thompson Jaron , Sun Zeyu , Hero Alfred O , Venturelli Ophelia S
Published: June 2022

Predicting the dynamics and functions of microbiomes constructed from the bottom-up is a key challenge in exploiting them to our benefit. Current models based on ecological theory fail to capture complex community behaviors due to higher order interactions, do not scale well with increasing complexity and in considering multiple functions. We develop and apply a long short-term memory (LSTM) framework to advance our understanding of community assembly and health-relevant metabolite production using a synthetic human gut community. A mainstay of recurrent neural networks, the LSTM learns a high dimensional data-driven non-linear dynamical system model. We show that the LSTM model can outperform the widely used generalized Lotka-Volterra model based on ecological theory. We build methods to decipher microbe-microbe and microbe-metabolite interactions from an otherwise black-box model. These methods highlight that Actinobacteria, Firmicutes and Proteobacteria are significant drivers of metabolite production whereas Bacteroides shape community dynamics. We use the LSTM model to navigate a large multidimensional functional landscape to design communities with unique health-relevant metabolite profiles and temporal behaviors. In sum, the accuracy of the LSTM model can be exploited for experimental planning and to guide the design of synthetic microbiomes with target dynamic functions.
Nanoscale architecture and coordination of actin cores within the sealing zone of human osteoclasts
Authors: Portes Marion , Mangeat Thomas , Escallier Natacha , Dufrancais Ophélie , Raynaud-Messina Brigitte , Thibault Christophe , Maridonneau-Parini Isabelle , Vérollet Christel , Poincloux Renaud
Published: June 2022

Osteoclasts are unique in their capacity to degrade bone tissue. To achieve this process, osteoclasts form a specific structure called the sealing zone, which creates a close contact with bone and confines the release of protons and hydrolases for bone degradation. The sealing zone is composed of actin structures called podosomes nested in a dense actin network. The organization of these actin structures inside the sealing zone at the nano scale is still unknown. Here, we combine cutting-edge microscopy methods to reveal the nanoscale architecture and dynamics of the sealing zone formed by human osteoclasts on bone surface. Random illumination microscopy allowed the identification and live imaging of densely packed actin cores within the sealing zone. A cross-correlation analysis of the fluctuations of actin content at these cores indicates that they are locally synchronized. Further examination shows that the sealing zone is composed of groups of synchronized cores linked by α-actinin1 positive filaments, and encircled by adhesion complexes. Thus, we propose that the confinement of bone degradation mediators is achieved through the coordination of islets of actin cores and not by the global coordination of all podosomal subunits forming the sealing zone.
Lactococcus lactis NCDO2118 exerts visceral antinociceptive properties in rat via GABA production in the gastro-intestinal tract
Authors: Laroute Valérie , Beaufrand Catherine , Gomes Pedro , Nouaille Sébastien , Tondereau Valérie , Daveran-Mingot Marie-Line , Theodorou Vassilia , Eutamene Hélène , Mercier-Bonin Muriel , Cocaign-Bousquet Muriel
Published: June 2022

Gut disorders associated to irritable bowel syndrome (IBS) are combined with anxiety and depression. Evidence suggests that microbially produced neuroactive molecules, like γ-aminobutyric acid (GABA), can modulate the gut-brain axis. Two natural strains of Lactococcus lactis and one mutant were characterized in vitro for their GABA production and tested in vivo in rat by oral gavage for their antinociceptive properties. L. lactis NCDO2118 significantly reduced visceral hypersensitivity induced by stress due to its glutamate decarboxylase (GAD) activity. L. lactis NCDO2727 with similar genes for GABA metabolism but no detectable GAD activity had no in vivo effect, as well as the NCDO2118 ΔgadB mutant. The antinociceptive effect observed for the NCDO2118 strain was mediated by the production of GABA in the gastro-intestinal tract and blocked by GABAB receptor antagonist. Only minor changes in the faecal microbiota composition were observed after the L. lactis NCDO2118 treatment. These findings reveal the crucial role of the microbial GAD activity of L. lactis NCDO2118 to deliver GABA into the gastro-intestinal tract for exerting antinociceptive properties in vivo and open avenues for this GRAS (Generally Recognized As safe) bacterium in the management of visceral pain and anxious profile of IBS patients.
A nucleation barrier spring-loads the CBM signalosome for binary activation
Authors: Rodriguez Gama Alejandro , Miller Tayla , Lange Jeffrey J , Unruh Jay R , Halfmann Randal
Published: June 2022

Immune cells activate in binary, switch-like fashion via large protein assemblies known as signalosomes, but the molecular mechanism of the switch is not yet understood. Here, we employed an in-cell biophysical approach to dissect the assembly mechanism of the CARD-BCL10-MALT1 (CBM) signalosome, which governs nuclear transcription factor-κB activation in both innate and adaptive immunity. We found that the switch consists of a sequence-encoded and deeply conserved nucleation barrier to ordered polymerization by the adaptor protein BCL10. The particular structure of the BCL10 polymers did not matter for activity. Using optogenetic tools and single-cell transcriptional reporters, we discovered that endogenous BCL10 is functionally supersaturated even in unstimulated human cells, and this results in a predetermined response to stimulation upon nucleation by activated CARD multimers. Our findings may inform on the progressive nature of age-associated inflammation, and suggest that signalosome structure has evolved via selection for kinetic rather than equilibrium properties of the proteins.
Adapting mark-recapture methods to estimating accepted species-level diversity: a case study with terrestrial Gastropoda
Authors: Rosenberg Gary , Auffenberg Kurt , Bank Ruud , Bieler Rüdiger , Bouchet Philippe , Herbert David , Köhler Frank , Neubauer Thomas A. , Neubert Eike , Páll-Gergely Barna , Richling Ira , Schneider Simon
Published: June 2022

We introduce a new method of estimating accepted species diversity by adapting mark-recapture methods to comparisons of taxonomic databases. A taxonomic database should become more complete over time, so the error bar on an estimate of its completeness and the known diversity of the taxon it treats will decrease. Independent databases can be correlated, so we use the time course of estimates comparing them to understand the effect of correlation. If a later estimate is significantly larger than an earlier one, the databases are positively correlated, if it is significantly smaller, they are negatively correlated, and if the estimate remains roughly constant, then the correlations have averaged out. We tested this method by estimating how complete MolluscaBase is for accepted names of terrestrial gastropods. Using random samples of names from an independent database, we determined whether each name led to a name accepted in MolluscaBase. A sample tested in August 2020 found that 16.7% of tested names were missing; one in July 2021 found 5.3% missing. MolluscaBase grew by almost 3,000 accepted species during this period, reaching 27,050 species. The estimates ranged from 28,409 ± 365 in 2021 to 29,063 ± 771 in 2020. All estimates had overlapping 95% confidence intervals, indicating that correlations between the databases did not cause significant problems. Uncertainty beyond sampling error added 475 ± 430 species, so our estimate for accepted terrestrial gastropods species at the end of 2021 is 28,895 ± 630 species. This estimate is more than 4,000 species higher than previous ones. The estimate does not account for ongoing flux of species into and out of synonymy, new discoveries, or changing taxonomic methods and concepts. The species naming curve for terrestrial gastropods is still far from reaching an asymptote, and combined with the additional uncertainties, this means that predicting how many more species might ultimately be recognized is presently not feasible. Our methods can be applied to estimate the total number of names of Recent mollusks (as opposed to names currently accepted), the known diversity of fossil mollusks, and known diversity in other phyla.
Workbench in the Teaching of Optics to Junior High School
Authors: Cuzzamu Emerson B.
Published: June 2022

Over the last 20 years, not much research has been carried out on improving teaching and learning process of Optics. The new technology in Optics teaching has a lot of advantages, which is impossible to be offered by any book. The study determined the status of textbooks in Physics of Optics in terms of availability, relevance of content, scope of subject-matter, and suitability; the degree of need for workbench in Optics; the validity of the proposed developed workbench in Optics as rated by Physics experts in terms of introduction, learning competencies, presentation of concepts, and exercises. The descriptive-developmental research design was used in the development of the workbench patterned from the ADDIE model. The content of the workbench was based on the competencies present in the K-12 science curriculum guide. The validity of the developed workbench was determined with the use of questionnaires. Results revealed that there is a limited number of textbooks for the subject Physics of Optics and there is an urgent need for a workbench in Optics. The content of the developed workbench is highly valid in terms of introduction, objectives, presentation of concepts and exercises. The developed workbench is strongly acceptable as instructional materials for students of Optics.