bluuebunny/crossref_metadata_2025 huggingface dataset:
Çölyak Hastalığı Olan Çocukların Ağız ve Diş Sağlığı Durumu
Authors: Bektaş Özge
Published: October 2023

Çölyak hastalığı buğday, çavdar ve arpada bulunan glüten alımının neden olduğu otoimmün bir hastalıktır. Çocukların yaklaşık %1’ini etkiler, ancak vakaların %90’ının teşhis edilmediği kabul edilir. Klinik olarak diyare, şişkinlik, kilo kaybı ve karın ağrısı gibi gastrointestinal belirtileri bulunmaktadır. Aynı zamanda mine defektleri, dişlerde sürme gecikmeleri, tekrarlayan aftöz ülserler gibi ağız belirtileri bulunmaktadır. Diş hekimleri rutin muayene ve diş tedavisi sırasında özellikle klinik semptom göstermeyen sistemik hastalığı olan çocuklarda çölyak hastalığının erken tanısında yönlendirme yapabilir. Erken tanı ile hastalığın tedavisine yönelik glütensiz diyete başlanması semptomların giderilmesine, bağırsak mukozasının iyileşmesine ve uzun dönemde gelişebilecek komplikasyonların önlenmesine yardımcı olur.
Bu derleme çölyak hastalığının tanısı, klinik bulguları ve ağız bulguları konusunda literatürdeki bilgileri değerlendirmektedir. Diş hekimleri özellikle çocuk hastalarda çölyak hastalığının ağız bulgularını detaylı bir şekilde sorgulayıp hastayı uygun hekime yönlendirerek erken teşhis ve tedavinin başlatılmasında önemli rol oynamaktadır. Çölyak hastalığı olan çocuklarda çoklu organ bozukluğu gelişebileceği için pediatristler, gastroenterologlar ve diş hekimleri arasındaki iş birliğine dayalı çalışma önemlidir.
Identification and understanding association of differentially expressed RNA in Renal Cell Carcinoma
Authors: Paul Niyanta , Tripathi Ritankar , Chakraborty Sohini , Banerjee Satarupa
Published: October 2023

Renal cell carcinoma, sometimes referred to as kidney cancer, is a condition in which kidney cells develop into malignant (cancerous) tumours and expand rapidly. One of the 20 most prevalent malignancies in both male and female is kidney cancer (GLOBOCAN 2020). The risk of developing kidney cancer in the male population is about 1/46 (2.02%) and for women, it is about 1/80 (1.03%). Renal cancer is significantly easier to identify when the disease hallmarks are properly understood, boosting the likelihood of overall survival rates among patients. One of the key factors for promoting or inhibiting the renal cancer associated pathways is messenger RNA. Messenger RNAs are single stranded RNA coding protein formation and also influence their regulation. Differentially expressed RNAs are the genes which have a significant correlation with their coding protein. Hence, analysis of the differentially expressed RNAs linked with kidney cancer is required to understand their significance in the underlying biogenesis of cancer tumorigenesis. To identify all the differentially expressed RNAs, microarray analysis technique was used which is an efficient tool to carry out simultaneous evaluation of hundreds of genes' expression. By physically printing DNA sequence information encoding RNA for specific genes onto microarray "chips," it is feasible to detect the quantity of each RNA molecule in a biological sample. Using the data from microarray analysis in GEO2R, differentially expressed RNAs are retrieved and categorized according to their regulation. Enrichr is used to analyse these differentially expressed RNAs and identify their role in different signalling pathways, biological functions, cellular elements and molecular activities. The results from this comprehensive in silico platform shall aid in a novel understanding of the DEGs involved in cancer pathways which can further be utilized in an experimental setup. Hence, this study will help in better understanding of the role and expression of the differentially expressed RNAs in renal cell carcinoma.
Metabolite Profiling and Bioactivity Assessment of Beet Juice fermented by Lactobacillus spp.
Authors: Aphurvika M. , Hemalatha M. , Mohanasrinivasan V. , Subathra Devi C.
Published: October 2023

Probiotic drink from fermented beet juice (Beta vulgaris) using Lactobacillus acidophilus and Lactobacillus plantarum was studied for its bioactive properties. The samples were assessed after 24h and 48h of fermentation for their physico-chemical changes and cell viability. Fermented juice showed a significant antibacterial activity against Listeria monocytogenes. Fermented beet juice exhibited a prominent anti-oxidant activity. When compared to fresh beet juice, more amount of total polyphenol content was detected in the fermented beet juice. The probiotic drink also exhibited anti-inflammatory and anti-hemolytic activity which exposed the potential usage of this probiotic drink in the pharmaceutical industry. The antibacterial activity observed against Listeria monocytogenes demonstrated that the fermented beet juice can be used to treat Listeriosis. The FTIR analysis and GC-MS results confirmed the presence of bioactive compounds in the fermented beet juice.
Identification of differentially expressed hub genes in Alzheimer’s disease using microarray dataset
Authors: Vijayasarathy Sampath Kumar , Veerappapillai Shanthi
Published: October 2023

An important factor that leads to the progression of Alzheimer’s disease is the amyloid-β peptide. Improper degradation of such molecules accompanied by reduced synaptic signaling contributes to the disease. Thus, a critical understanding of proteins interacting in peptide degradation, synaptic transmission and cognition is important to understand the disease progression. In this study, a dataset from public databases was taken and differential gene expression analysis was implemented along with network construction and gene ontology. This gives us more insights into the various biological parameters that are affected and their genetic basis to understand the disease. With a cut-off in adj P-value and log 2-fold change, differentially expressed (DEG) were identified using R. The enrichment analysis resulted in three hub genes which are SST, GFAP and GABRD. These genes have been found to dysregulate crucial processes in Alzheimer’s disease etiology. These three genes are the main drivers of disease and targeting them could essentially reduce disease progression. These could also be used as markers to identify the disease and can be used in diagnostics.
Bioplastic (Polyhydroxyalkanoate) producing Indigenous Bacteria from Agricultural Soil Samples
Authors: Kola Pratap Jyothirmayee , Badme Shravani Ratnakant , Tendulkar Siddhi Avadhut , Bhatt Sakshi , Kannabiran Krishnan
Published: October 2023

Polyhydroxyalkanoate (PHA) is the naturally occurring biopolymer produced by the microorganisms. It is biodegradable and having physicochemical properties similar to conventional synthetic plastics and it can be used as an alternative to plastics. PHA is produced by microorganisms including bacteria, archaea and fungi. It gets accumulated inside the microorganisms as crystal in the presence of excess source of carbon, nitrogen, sulphur, oxygen and limited source of other nutrients. In this study PHA producing strain was isolated from agricultural soil sample. All the isolates obtained were screened for PHA production by using Nile red and Sudan black dyes. The potential isolate was characterized by biochemical tests and identified using 16S rRNA sequencing. The isolate showed sequence similarity with Priestia aryabhattai B8W22 and was designated as Priestia aryabhattai VITJK01. For PHA production, seed culture was prepared and inoculated in mineral salt medium containing glucose as a carbon source. PHA was extracted from cell dry weight biomass using methanolysis. It produced polyhydroxybutyrate (PHB) compounds including dodecane, penta decanoic acid, octadecanoic acid and heptadecanoic acid identified by Gas Chromatography Mass Spectrometry. Based on the results, it can be concluded that Priestia aryabhattai VITJK01 is a potential source for PHA/PHB production.
Inhibitory Effect of Indian Spices on Selective Bacteria
Authors: Sairam A. , Mishra T. , Vuppu S.
Published: October 2023

The rise of antibiotic resistance due to the evolution of resistance mechanisms in bacteria and the enhanced tolerance in human bodies have proven to be serious threats. This is attributed to the critical impact antibiotics have on healthcare systems in addition to an extreme reliance on them for the treatment of infections. The rise of superbugs and antibiotic-resistant bacteria such as MRSA (Methicillin-Resistant Staphylococcus aureus) and the severe global pandemic of COVID-19 have increased the demand for novel antimicrobial compounds. The study aims to examine the efficacy of numerous Indian spices as well as various varieties of camphor and kumkum when dissolved in ethanol and distilled water against four bacterial cultures: Staphylococcus aureus, Pseudomonas spp., Bacillus subtilis and Escherichia coli. After 24 hours of incubation, the zones of inhibition of each culture were measured and docking studies were performed to determine the interaction between ligands (phytochemicals) and the bacterial receptors, thereby enhancing the antimicrobial properties of the compounds. The analysis revealed that turmeric-based Kumkum, black pepper and Tulasi (Ocimum tenuiflorum) are the most potent antibacterial compounds.
SARS-CoV-2 Screening on the Multiplex Real-Time RT-PCR Gene Cycle Threshold - A Machine Learning Approach
Authors: Karthik Sekaran , Gnanasambandan R. , Ramya Iyyadurai , Karthik G. , George Priya Doss C.
Published: October 2023

Early diagnosis of the lethal SARS-CoV-2 virus determines a patient’s survival rate. Highly transmissible novel coronavirus prevention is possible with effective, rapid diagnostic strategies. The reverse transcription polymerase chain reaction (RT-PCR), a globally adopted SARS-CoV-2 detection technique, provides better diagnosis results. The output of the RT-PCR test produces the amplified gene scores of ORF1a/b, S, N, E and RdRp. This study intends to evaluate the performance of the RT-PCR-based COVID-19 diagnosis using machine learning models. The confirmatory genes ORF1b, E and RdRp and their cycle threshold (Ct) values are the main parameters used to build the machine learning model for SARS-CoV-2 screening. The real-time dataset collected from the Indian Council of Medical Research (ICMR) database containing missing, redundant information is processed and eliminated. Statistical interpretations are performed with demographic information to understand the dynamics of the disease prevalence in India. Binary classification models delivered promising results in discriminating the samples of two classes. The models were examined further to scrutinize their performance via evaluation metrics such as balanced accuracy, f1-score, ROC curve, precision and recall. This algorithmic assessment exhibits a better outcome on the RT-PCR-based SARS-CoV-2 disease diagnosis.
Development of machine learning models for post-operative recurrence prediction in lung cancer patients
Authors: Dhakshinamoorthy Dhayanitha Ranganathan , Thirunavukkarasu Muthu Kumar , Veerappapillai Shanthi , Karuppasamy Ramanathan
Published: October 2023

Surgical treatment is one of the best approaches to provide a better cure for lung cancer patients. Despite the technological advancements, the increase in lung cancer recurrence rate urges the development of an early-stage predictive model. Therefore, we carried out machine learning algorithms to predict post-operative recurrence in lung cancer patients. It is to note that 80% of patient data was used for the model development and 20% of patient data was used for validation of the model. Besides, the important parameters were found using the extra tree classifier and correlation analysis. Notably, OS, DFS time and tumor size were ensured higher importance during the feature selection process. Random forest achieved the highest accuracy score of 96% than the other algorithms investigated in this study. Indeed, prior consideration of the important features together with the random forest algorithm will help surgeons to make effective treatment progress in lung cancer patients.
Micro-RNAs and lung cancer: A focus on signaling pathways and therapeutics
Authors: Banerjee Sohom , Koilerian Sharanya , Mandal Abul Kalam Azad
Published: October 2023

Micro-RNAs are short sequences of single-stranded RNA that do not code for proteins but play a crucial role in modulating gene expression in the cell. Micro-RNAs can downregulate the expression of genes and can modify different pathways that are important for proper functioning of the cells. Micro-RNAs are effective as potential biomarkers and therapeutic targets against various diseases including lung cancer. In this review, we take a look at the different micro-RNAs expressed in lung cancer and their targets in various signaling pathways like Wnt, RAS/RAF, PI3K/Akt pathway etc. We also evaluate the current status of micro-RNA - based therapeutics against Small Cell Lung Cancer and Non-Small Cell Lung Cancer, both in the context of pre-clinical studies as well as clinical studies conducted on humans to date.
A critical review of the food colourants effects on Human Health and Environment
Authors: Jananipriya R. , Usha S.
Published: October 2023

Food colour is a common food additive. Colour is essential for food which enhances the specific appearance of the food product and freshness. Hence, the use of artificial food colourants has increased tremendously during the past decades. Studies have reported that usage of synthetic food colouring in food products leads to severe health issues. The continuous use of synthetic food colourants causes behavioural changes like attention deficit, hyperactivity disorder in children and allergic reactions. Several researchers have reported that food-borne diseases are mainly caused by non-permitted colours. Synthetic food colours not only affect individuals, but They are also a potential cause of water contamination and much more environmental effects. Taking this into account, this study reviews the effect of synthetic colourants on humans and environment.
Urgent imperatives and perspectives of Antimicrobial resistance
Authors: Ashwin Venkatasubramanian , Chandra Veluchamy , Rajasekaran Chandrasekaran , Kalaivani Thiagarajan
Published: October 2023

Antimicrobial resistance (AMR) is a pressing global health issue that threatens the effectiveness of antibiotics in treating infectious diseases. This study examines the current landscape of AMR with a specific focus on the emergence and spread of multidrug-resistant bacteria. The factors contributing to the development and spread of AMR including the overuse and misuse of antibiotics in human and animal health sectors are discussed. The mutations of bacterial genes causing AMR, highlighting their role in promoting the survival and proliferation of drug-resistant bacteria are analyzed. The consequences of AMR are far-reaching and include increased morbidity, mortality and healthcare costs. The assessment highlights the impact of medical wastes such as patient samples, clinical and drug wastes and agro-based wastes such as surface runoff of poultry and cattle medication on AMR. To address the challenge of AMR, the analysis emphasizes the need for novel antimicrobial agents. The importance of public awareness, awareness among decision makers and appropriate attention and schemes is also discussed as a promising approach to combat AMR. In conclusion, this appraisal sheds light on the escalating problem of AMR and the urgent need for effective strategies to wrestle it. The findings underscore the importance of a multidisciplinary approach involving healthcare professionals, researchers, policymakers and the public to mitigate the impact of AMR and to ensure the availability of effective treatments for infectious diseases in the future. By addressing the challenges posed by AMR, we can safeguard public health and promote sustainable use of antibiotics.
Platon Oyunsky as a writer of romanticism: to his 130th anniversary
Authors: Okorokova V. B. , Filippov G. G.
Published: October 2023

Platon Alekseevich Oyunsky (1893 – 1939) was the founder of Yakut Soviet literature, a revolutionary, and a major statesman. Considering the Russian writer of revolutionary-romantic style Maksim Gorky as his teacher, Oyunsky founded the poetry of struggle and storm. Oyunsky was a bearer of the Yakut folklore and an olonkhohut storyteller. That is why his works at the levels of language, images and plots are closely connected with the oral folk art. As a scholar, he was the first to conduct a research on the Yakut heroic epic "Yakut tale (olonkho), its plot and content" (1927). He was also the first to compose a classic sample of the Yakut olonkho "Nurgun Botur the Swift" of 40 thousand lines (1932), thanks to which the whole world learnt this work, and the olonkho was recognised by UNESCO as a universal masterpiece (2005). The article aims to investigate the origins of Oyunsky's artistic method – romanticism. The question of topical importance is the definition of his creative method and style. The article aims to investigate the origins and principles of Oyunsky's artistic method on the basis of historical and specific method and genesis of the writer's creative quest. The study substantiates the conclusion that Oyunsky's romanticism determined his original and unique style in Yakut literature.
Mythological and folklore poetics of the novel "Zuleikha opens her eyes" by Guzel Yakhina
Authors: Oshchepkova A. I. , Sleptsova V. N.
Published: October 2023

The article considers the representation of mythological and folklore poetics in the Guzel Yakhina's novel "Zuleikha opens her eyes". The article attempts to show the productivity of the fairy tale archetype in the plot structure of this work. The analysis of the spatial structure of the novel shows that the components of the archetypal model of the initiatory myth are isolated in the composition. The narrative structure of the work recreates folklore poetics, which reveals a transformational model of a fairy tale with the interpenetration of the more archaic mythological semantics behind it. The methodological basis of the study is the individual provisions of the works of V. Y. Propp, Y. M. Lotman, E. M. Meletinsky, S. Yu. Neklyudov, and V. I. Tyupa.
The economic condition of a bakery enterprise
Authors: Borisova O. I. , Barakhoeva A. A. , Bagaeva N. Yu.
Published: October 2023

The article examines the economic condition of a bakery enterprise in the context of a financial analysis of the activities of JSC “Yakut Bakery”. During the study period, the research showed that its condition is in a rather unstable position. The situation is characterized by a considerable decrease in the company’s profit and net profit, compared to previous periods, by 37.89%. The main reason for this situation is the excess of non-current assets over current assets, and this is a consequence of the fact that there are current assets that are not involved in economic turnover and have not been used in the production for a long time. The authors found out that it is necessary to extract non-current funds and ensure their liquidity so as to attract their own funds to increase the economic activity of the enterprise. In the process of settlement and economic measures, the authors revealed the ability of the bakery enterprise to meet its obligations in the current time; however, the financial and economic situation of JSC “Yakut Bakery” is not able to attract additional borrowed funds. This result represents the calculations of the liquidity ratio and profitability indicators of the bakery enterprise. The indicators of financial stability and the coefficient of financial stability, the dynamics of which is negative, are also quite weighty evidence. Therefore, the authors formed recommendations for the liquidation of the working capital to ensure the possibility of attracting borrowed funds and strengthen the market and competitive positions of the bakery enterprise
Developing a Complex of Measures for the Entry of the Enterprise to the International Market: The Case of Tuymaada Real Estate LLC
Authors: Daybannyrova N. K. , Sibileva E. V.
Published: October 2023

Today, one can often hear that enterprises are trying to export their products abroad. We often come across the concept of “foreign goods”. All this is done in order to find new clients outside of their home country. The article focuses on the development of a set of activities necessary for the Tuymaada Real Estate Agency to enter the international market. The relevance of the research topic is due to the need to reduce competitors and enter the global market, with the necessary experience and a sufficient satisfied client base. The purpose of the article is to identify key factors for successful market entry and develop recommendations for the effective development of Tuymaada Real Estate LLC. The research utilizes market analyses of potential competitors, as well as a SWOT analysis and a comprehensive approach to developing business strategy and activities. The research identified the key advantages and competitive advantages of the company on the global market, as well as growth and development areas. In addition to that, recommendations and activities for the effective entry of Tuymaada Real Estate Agency into the international market and achieving successful business development were developed. The prospects for promoting the company in the global market are promising, which makes this research timely and relevant. Methods: descriptive method, analysis method, synthesis method, abstract-logical evaluation method. As a result of the study, theoretical aspects of the strategies for entering enterprises into international markets were formulated; an analysis of the economic indicators of Tuymaada Real Estate LLC was carried out, a set of strategic measures was developed to bring Tuymaada Real Estate LLC to the international market of Dubai.
TO THE QUESTION OF THE INITIAL HISTORY OF THE CITY OF PLES
Authors: Несмиян О.А. , Несмиян В.Г. , Кузьмичёва О.В.
Published: October 2023

В статье сделана попытка разобраться в начальной истории Плеса с привлечением данных археологии, топонимики и историографии, а также отойти от дилетантских построений и историографических легенд. В статье вводятся в научный оборот новые материалы из раскопок в Плесе 2016–2018 гг.

The article makes an attempt to understand the initial history of Ples using data from archeology, toponymics and historiography, as well as to move away from amateur synthesis and historiographical legends. The article introduces into scientific discourse new materials from the excavations in Ples in 2016–2018.
ABOUT IMITATION OF «SUZDAL HYSTERA-AMULET»
Authors: Лапшин А.Г.
Published: October 2023

Ближайшей аналогией «Суздальскому змеевику» является «составной каменный змеевик» из коллекции А. А. Бобринского. Эти два амулета сближает иконография, материал, надписи на русском языке. Амулет А. А. Бобринского принято считать антикварной подделкой. Однако компаративный анализ амулетов позволяет заключить, что «составной каменный змеевик» является не подделкой, но аналогией «Суздальскому змеевику», относится к категории изделий медицинского назначения и воплощает медицинскую традицию с историей более 2000 лет.

The closest analogy to the «Suzdal hystera-amulet» is the «composite stone hystera-amulet» from the collection of A. A. Bobrinsky. These two amulets are brought together by iconography, material, inscriptions in Russian. The amulet of A. A. Bobrinsky is considered to be an antiquarian imitation. However, results of comparative analysis of both amulets bring us to conclude that the «composite stone hystera-amulet» is not an immitation, but an analogy to the «Suzdal hystera-amulet», belongs to the category of medical device and embodies a medical tradition with a history of more than 2000 years.
A FRAGMENT OF A BONE RELIEF FROM THE EXCAVATIONS OF 2021 IN THE GREAT ALEXANDROVSKAYA SLOBODA
Authors: Томсинский С.В.
Published: October 2023

представляет первый памятник портативной пластики эпохи Московского царства из материалов раскопок 2021 г. в Александровской слободе – резиденции Василия III и Ивана IV Грозного в 1513–1582 гг. Изображение милостивого блудника на миниатюрном костяном рельефе может быть признано уникальным для сакрального искусства XVI в.

The article presents the first monument of portable plastics of the era of the Moscow Kingdom from the materials of excavations in 2021 in the Alexandrovskaya Sloboda – the residence of Vasily III and Ivan IV the Terrible in 1513–1582. The image of the merciful fornicator on a miniature bone relief can be recognized as unique for the sacred art of the XVI century.
RESULTS OF PALEOECOLOGICAL RESEARCH IN THE VYzHEGSHA FORTIFIED SETTLEMENT: MALT BARLEY, METALwORKING, AND RADIOCARBON CHRONOLOGY OF OCCUPATIONS
Authors: Пономаренко Е.В. , Александровский А.Л. , Леонтьев А.Е.
Published: October 2023

В статье представлены результаты естественнонаучных исследований на городище Выжегша и радиоуглеродная хронология памятника. Всего получены 32 даты, среди которых выявляются две основные группы – раннего Средневековья и раннего железного века. Из культурного слоя в заполнении постройки второй половины VIII – IX в. на уровне материка с помощью мокрого просеивания выделены многочисленные обугленные зерна ячменя и единично – обугленные зерна пшеницы, проса и гороха. Сорняки посевных культур были представлены единичными семенами неслии метельчатой – растения, типичного для более восточных регионов. Все семена ячменя были проросшими и ферментированными перед обугливанием, что свидетельствует о производстве солода. Возраст зерна – середина VI – начало VII в. н. э. – совпадает с возрастом погребенного горизонта подсеки, вскрытого под валом на верхней площадке городища, и подтверждает существование здесь поселения до устройства вала. Кроме того, были обнаружены отходы кузнечного и литейного производства: мелкие пластинки железа и капли застывшего черного и цветного металла.

The paper presents results of paleoecological studies and radiocarbon chronology of Vyzhegsha fortified settlement. The 32 radiocarbon dates are clustered in two groups, dated by the Early Iron Age and the Early Middle Ages. Analysis of macrofossils from infill of a semisubterranean dwelling dated by the late 8th to 9th cent. AD revealed presence of charred seeds of barley, wheat, millet, and pea, with barley seeds being the most numerous. The only weed seeds were of ball mustard (Neslia paniculata), a weed typical for the Mid-Volga and Cis-Kama regions. All barley grains were germinated and fermented prior to charring, indicative of malt production. Radiocarbon dating of the grains yielded age of mid-6th to early 7th cent. AD. Charcoal from a swidden layer buried under the earth fortification wall had a similar age, indicating that a settlement existed here prior to the construction of fortification walls. Besides the charred grains, the infill contained iron working refuse: thin plates of forged iron and drops of both ferrous and non-ferrous alloys.
RESEARCH OF THE HILLFORT OF VYzHEGSHA IN 2021
Authors: Леонтьев А.Е.
Published: October 2023

В продолжение работ 2019–2020 гг. на центральной площадке городища в раскопе 1 было завершено исследование участка ремесленной мастерской второй половины VIII – IX в., связанной с ювелирным и кузнечным ремеслом. Рентгенофлюоресцентный анализ отходов литья показал преобладание серебряных сплавов высокой пробы. Находки обломков дирхемов подтверждают вероятность использования в качестве сырья монетного серебра. Среди предназначенного для переплавки металлического лома есть фрагменты импортных изделий, а также украшений, характерных для финноязычного населения Верхнего Поволжья. Две находки по своему возрасту значительно старше и датируются первыми веками н. э. В шурфе у восточной кромки мыса обнаружены следы заглубленного в материк сооружения. Шурф в западной части напольной площадки показал отсутствие в этом месте культурного слоя.

In continuation of works started in 2019–2020 a study of a plot in the central part of Vyzhegsha fortified settlement where a craft workshop which existed in the second half of the 8th and in the 9th centuries and was connected with jewellery and ironmongery has been accomplished. The roentgen and fluorescent analysis of cast wastes showed predominance of silver alloys with high content of silver. Findings of dirham fragments attest probability and possibility of monetary silver use as raw stuff. Among metal scraps designated for remelting there are fragments of imported items. Two findings are much older than the rest: they are dated by the first centuries A. D. In a hole dug at the eastern edge of the cape traces of a construction which had been deepened into mainland were found. A hole dug in the western part of floor field showed that the occupation layer was absent there.
OPEN TRADE AND CRAFT SETTLEMENT GOROzHANE ON THE wATERSHED OF LOVAT AND VELIKAjA: THE ARCHAEOLOGICAL RESEARCH IN THE YEAR 2016–2021
Authors: Михайлов А.В.
Published: October 2023

Поселение Горожане располагается в юго-восточной части Бежаницкой возвышенности, на водоразделе бассейнов рек Великой и Ловати. Площадь поселения составляет около 3 га, мощность культурных отложений – 0,6–0,8 м. Под слоем распашки сохранился непотревоженный культурный слой мощностью до 0,4 м, который содержит следы крупного пожара. В слое пожара встречены остатки нескольких отопительных устройств. Предварительная датировка пожара – конец X в. Керамический комплекс на 85 % состоит из лепной керамики. Находки гончарной керамики единичны. Коллекция индивидуальных находок представлена 1000 предметами. Значительную часть коллекции составляют стеклянные и каменные бусы. Кроме того, среди находок представлены предметы вооружения, украшения, торговый инвентарь, бытовые предметы, несколько дирхемов. Поселение Горожане можно считать одним из ключевых пунктов торгового пути между бассейнами Ловати и Великой. Этот памятник по ряду параметров (достаточно узкая датировка (X в.), мощность и хорошая сохранность культурных отложений, вещевая коллекция) является значимым археологическим объектом для изучения ранней истории Древней Руси.

The Gorozane settlement is located in the South-Eastern part of Bezhanitsky highland, on the watershed between the basins of the Velikaya and Lovat rivers. The settlement area is about 3 ha, the cultural deposits density is 0,6–0,8 m. There is an intact cultural layer of up to 0,3 m thickness containing traces of big fire under the plowing layer. There are remnants of an adobe oven and a heater in the fire layer. The fire dates from the end. 10th c. 85 % of the ceramics are molded ones. There are only several finds of pottery ceramics. Individual findings are presented by 1000 items. The significant part of them consists from glass and stone beads. There are weaponry, adornments, trading equipment, household utensils and several dirhams too. The Gorozhane settlement is certainly one of the key points on the trading route between Lovat river and Velikaya river basin areas. The features of this monument (rather narrow dating (10th c.), density and good preservation of cultural deposits, material collection) make it an important archaeological site for the early history of Ancient Rus.
Utilizing an Improved EXAFS Structure Analysis Method to Reveal Site-Specific Bonding Properties of Ag44(SR)30 Nanoclusters
Authors: Chen Ziyi , Chevrier Daniel , Conn Brian , Bigioni Terry , Zhang Peng
Published: October 2023

Atomically precise nanoclusters (NCs) are of great interest due to their well-defined structures and molecule-like properties. Understanding their structure-property relationship is an important task because it can help tailor their structures to achieve specific desired properties. In this study, the temperature-dependent bonding properties of Ag44(SR)30 have been revealed by the extended X-ray absorption fine structure (EXAFS) with a new structure analysis method, which includes two Ag-S and two Ag-Ag fitting shells. It has been proven that the EXAFS fitting quality can be improved significantly compared with the conventional method. New insights into Ag-S bondings were discovered based on the fitting results obtained from the new method. It allows us to observe two different bonding properties within the Ag-S motifs, which cannot be discovered by using the conventional method. Additionally, the metal core of Ag44(SR)30 exhibits uncommon thermal behavior, which could be connected to the absence of the center atom in the icosahedral core. Our results demonstrate that the new structure analysis method can provide a more reliable comparison of NCs structural changes than the conventional method and it could be applicable to other NCs. The revealed temperature-dependent bonding properties can provide insights into the structure-property relationship of Ag44(SR)30, which can help design new NCs materials with tailored properties.
Massive Molecular Motion in Crystal Lattice Leads to an Unexpected Product in a Topochemical Polymerization
Authors: Sureshan Kana , Ravichandran Khazeber , Kana Gautham
Published: October 2023

We synthesized a designed proline-derived monomer decorated with azide and alkene for topochemical ene-azide cycloaddition (TEAC) polymerization. The monomer, in its crystal, assembles as supramolecular helices along the ‘a’ axis by exploiting various non-covalent interactions. Along the ‘c’ axis, the molecules are head-to-tail arranged in a wave-like topology such that the azide and alkene of adjacent molecules are proximally and anti-parallelly organized, obeying Schmidt’s criteria for topochemical reaction. This ready-to-react arrangement, resembling the transition-state arrangement for their cycloaddition, is expected to facilitate a smooth topochemical polymerization forming 1,4-triazoline-linked polymer along the ‘c’ direction. Upon heating, the monomer underwent regio- and stereospecific TEAC polymerization in a single-crystal-to-single-crystal fashion, as evidenced by SCXRD analysis. Surprisingly, it produced an unexpected 1,5-disubstituted-triazoline-linked covalent helical polymer along the ‘a’ axis rather than the expected 1,4-disubstituted-triazoline-linked wave-like polymer along ‘c’ axis. The polymerization linked the monomer molecules within the supramolecular helix via the cycloaddition between azide and alkene groups that are neither proximal nor in a suitable orientation. Interestingly, the crystal avoided a ready-to-react arrangement and chose an unexpected path involving a massive rotation of 134o of the alkene group, leading to a transient but new reactive arrangement followed by TEAC polymerization. This is the first regiospecific ene-azide cycloaddition reaction that yielded the 1,5-disubstituted product. This study cautions that the use of topochemical postulates for the prediction of reactivity can sometimes be misleading.
Deep Learning Based Anticancer Drug Combination Discovery Through Natural Compounds and Pharmaceutical Drugs
Authors: Cao Elton
Published: October 2023

Drug combination therapies have shown effective performance in treating cancer through increased efficacy and circumvention of drug resistance through drug synergy. Two avenues can be used to discover drug combinations: a novel approach that utilizes natural products compared with the textbook approach of utilizing existing chemotherapy drug combinations. Many natural products achieve efficacy due to synergistic interactions between the active ingredients. Therefore, the pharmacophore relationships in herbal compounds which synergize can potentially be applied to chemotherapy drugs to drive combination discovery. Machine learning approaches have been developed to identify drug combinations, especially deep neural networks (DNN), which have achieved state-of-the-art performance in many drug discovery tasks. Here, we developed a drug protein interaction (DPI) prediction DNN, DeepDPI, to employ DPI drug representations and achieved state-of-the-art performance. Two DNNs were also developed to predict novel drug combinations: DeepNPD, which predicts combinations in herbs, and DeepCombo, which predicts synergy in chemotherapy drugs. We used an ensemble architecture enhanced with a novel similarity based weight adjustment (SBWA) approach and both models accurately predicted drug combinations for both known and unknown drugs. Lastly, a screening was conducted using each model where DeepNPD predicted combinations where drugs had similar targets, while DeepCombo predicted combinations where one agent potentiated the other, with both models’ predicted combinations investigated through a network-based analysis and identifying as a synergistic combinations in literature. DeepNPD illustrates how natural products are a novel path where new drug combinations can be discovered.
Development of First-in-Class Dual Sirt2/HDAC6 Inhibitors as Molecular Tools for Dual Inhibition of Tubulin Deacetylation
Authors: Sinatra Laura , Vogelmann Anja , Friedrich Florian , Tararina Margarita , Neuwirt Emilia , Colcerasa Arianna , König Philipp , Toy Lara , Yesiloglu Talha , Hilscher Sebastian , Gaitzsch Lena , Papenkordt Niklas , Zhai Shiyang , Zhang Lin , Romier Christophe , Einsle Oliver , Sippl Wolfgang , Schutkowski Mike , Groß Olaf , Bendas Gerd , Christianson David , Hansen Finn , Jung Manfred , Schiedel Matthias
Published: October 2023

Dysregulation of both tubulin deacetylases sirtuin 2 (Sirt2) and the histone deacetylase 6 (HDAC6) has been associated with the pathogenesis of cancer and neurodegeneration, thus making these two enzymes promising targets for pharmaceutical intervention. Herein, we report the design, synthesis, and biological characterization of the first-in-class dual Sirt2/HDAC6 inhibitors as molecular tools for dual inhibition of tubulin deacetylation. Using biochemical in vitro assays and cell-based methods for target engagement, we identified Mz325 (33) as a potent and selective inhibitor of both target enzymes. Inhibition of both targets was further confirmed by x-ray crystal structures of Sirt2 and HDAC6 in complex with building blocks of 33. In ovarian cancer cells, 33 evoked enhanced effects on cell viability compared to single or combination treatment with the unconjugated Sirt2 and HDAC6 inhibitors. Thus, our dual Sirt2/HDAC6 inhibitors are important new tools to study the consequences and the therapeutic potential of dual inhibition of tubulin deacetylation.
Palladium-Catalyzed, Highly Regio-, Stereo-, and Enantioselective Anti-Carboxylation of Unactivated Internal Allenes
Authors: Nagtilak Prajyot Jayadev , Mane Manoj V. , Hirapara Deveen Rajeshbhai , Jain Akshat , Kapur Manmohan
Published: October 2023

Presented herein is the first report of a directing group-controlled, palladium-catalyzed, regio-, stereo-, and enantioselective anti-carboxylation of unactivated, internal allenes enabled via the synergistic interplay of rationally designed bidentate directing groups, palladium catalyst, and multifunctional acetate ligand. The corresponding trans allyl ester was obtained in excellent yields with exclusive delta-regioselectivity and anti-carboxypalladation stereocontrol. The pair of palladium catalysts coordinated with the bidentate directing group control regio-, and stereo- and enantioselectivity in the desired transformation. The potential of this concept has been demonstrated by the development of the first example of a chiral version of this transformation by using axial-to-central chirality transfer with high yields and good enantioselectivities. Several control experiments were conducted to validate the ligand-assisted nucleopalladation process and the rationale behind the racemization of chiral allenes. Detailed investigations, including kinetic studies, order studies, and DFT studies, were performed to elucidate the mechanism of this transformation, indicating that the anti-carboxypalladation step was the rate-limiting as well as the stereo- and enantio-determining step.
TomoSuitePY: A Pythonic Workflow for Noisy and Sparse Angle Tomography
Authors: Judge William , De Andrade Vincent , Bicer Tekin , De Carlo Francesco , Cabana Jordi , Allen Eva
Published: October 2023

Advancements in machine learning have introduced innovative approaches for analyzing and enhancing tomographic datasets. However, many of these neural networks pose challenges for non-technical users, limiting their practical application at high-speed synchrotron tomography instruments. This manuscript introduces TomoSuitePY, a Python-based module that streamlines multiple neural networks into a user-friendly workflow for tomographic denoising and upsampling sparse angles. Within this framework, we propose a novel approach to address sparse angle datasets by interpolating frames between projections. To validate this method, we present various performance metrics applied to an ex-situ study of a neural network on a cathode material, specifically LiNi0.8Mn0.1Co0.1O2.
Management of Sialocele Secondary to Iatrogenic Parotid Duct Injury: A Case Report
Authors: Singh Rajdeep , Sharma Anshul , Elizabeth Thomas Amy , Mishra Yashi , Majumdar Basumita , Vindhya Vasini Dasari
Published: October 2023

Sialocele is extra glandular subcutaneous collection of saliva. Etiology ranges from trauma or laceration to the salivary duct or the gland parenchyma itself. The injurious cause can be trauma or insult from surgeries involving the salivary gland like superficial parotidectomy. The objective of this study is to bring in light the potential of iatrogenic trauma to the Stensonrsquos duct. The paper also includes the key to diagnosis and surgical technique to correct the sialocele resulting from the ductal injury. The surgical procedure of ductal repair of two patients of Sialocele was conducted in the Department of Oral and Maxillofacial Surgery CDCRI. The treatment included distal canulation of the duct intra-orally extra-oral surgical exploration removal of the cystic lining in one patient and catheterising with a paediatric feeding tube the distal part of the duct up to the site of saliva accumulation. Post-operative monitoring done with thorough irrigation and pressure dressing. After 21 post operative days the patency of the tract for saliva drainage was marked. Removal of the feeding tube also showed intact saliva drainage on stimulation. Treatment spectrum ranges from conservative medicinal treatment anti-cholinergic drugs administration and surgical intervention. Enucleation and Catheterization is a promising treatment modality.
A One-Year Comparative Evaluation of Clinical Performance of Activa™ Bioactive composites with Microhybrid Composite In Abfraction Lesions: A Randomized Control Study
Authors: B J Prathima , Karale Rupali
Published: October 2023

Aim This double-blind randomized controlled study aimed to compare and evaluate the clinical performance of Activatrade bioactive composites with microhybrid composites in abfraction lesions. Methodology Thirty-four teeth having abfraction were randomly divided into two groups n17 per group depending on the restorative material used. Group Andash Microhybrid composite and Group B ndash Activa composite. Initially occlusal contacts were evaluated for the patients and required occlusal adjustments were carried out. Restorations were done according to the manufacturerrsquos guidelines. Evaluation of the restorations was done at baseline 1 month 6 months and 1-year time interval by two blinded examiners as per the modified United States Public Health Service USPHS criteria. The statistical analysis was carried out and the results were tabulated.Results The clinical performance of microhybrid and Activa showed no statistically significant difference at post-op 1 month 6 months and 1 year pgt0.05. In intragroup assessment between baseline and 6 months both groups yielded similar clinical behavior whereas at 1 year a statistically significant difference p0.046 was noted with marginal adaptation in microhybrid group.Conclusion Acceptable clinical performance was shown by both groups by the end of 1 year. However discrepancies were noted in the marginal adaptation criteria for microhybrid. Active composites can be considered as the material of choice for restoring abfraction.
Dentophobia, Exploring Parental Factors - A Cross-sectional Survey
Authors: Bhatt Sahana , Nihala K Fathimath , Nagar Priya , Saseendran Anagha
Published: October 2023

Aim To examine the relationship between parentsrsquo socioeconomic status parental dental anxiety parenting style on childrenrsquos oral health behaviour childrenrsquos dental anxiety and dental visit frequency.Methods A cross-sectional study was designed with a sample of 101 physically and mentally healthy children in the age group of 6-13 years. Two google forms were formulated. One for the parents to fill out and the other form for the child. Form 1 to be filled by the parent included four sections - Socio-demographic details Dental anxiety scale CORAHrsquoS revised DAS-R Parenting style and dimension questions PSDQ Childrenrsquos fear survey schedule CFSS-DS. Form 2 to be filled by the child included three sections - Dental anxiety scale CORAHrsquoS revised DAS-R Oral health behaviour perception scale and Childrenrsquos fear survey schedule CFSS-DS.Using the results of the two formsThe proportion of children with dental anxiety was assessed.Comparison of childrenrsquos dental anxiety to those of their parents was done.The correlation between parenting style to a childrsquos dental anxiety was assessed.Childrsquos oral health behaviour was correlated to their anxiety.Socioeconomic status with oral health behaviour was assessed.Childrsquos degree of anxiousness was determined.Results This study investigated the association between childrenrsquos dental fear and anxiety DFA and family-related factors. It showed significant correlation between dental anxiety of children and dental anxiety of parents oral health behaviour of parents fear in parents. Oral health behaviour perception of children was found to be significantly associated with dental anxiety of parents oral health behaviour perception of parents and fear in parents. Fear in children was found associated with dental anxiety of parents oral health behaviour perception of parents.Conclusion It can be concluded that parentsrsquo dental fear and anxiety are reflected in their children. It in turn affects the childrsquos oral hygiene behaviour
Implant Compression Necrosis: A Scrupulous Review
Authors: Kaur Sunpreet , Bhardwaj Amit
Published: October 2023

Currently when the implant is placed it deals with various mechanical stresses before it integrates with the bone. The stresses may cause micromovement that jeopardises the healing process in early stages. These stresses aggravate as the implant goes deeper into the bone and somewhat accounts for increased friction and torque. Excess torque at the insertion time may lead to bone compression which if crosses its physiologic limit may lead to a bloodless field i.e. ischemia following necrosis or sequestrum formation which in turn will cause implant failure. This is termed as compression necrosis. Too much torque levels may result in high levels of strain transmitted to adjacent bone. The crestal area around the implant is mainly comprised of cortical bone which has minimum blood supply and is exposed to extreme strain making it more vulnerable to bone necrosis and which is paramount to the failure of implant. An attempt has been made to review the physiologic effect of alveolar bone on compression necrosis the mechanism and histopathology behind compression necrosis factors leading to compression necrosis like excess torque strain macrogeometry of implants implant design and methods to avoid compression necrosis.
A Matter of Fact: Cold Atmospheric Plasma in Periodontics
Authors: Arif Salma , Melath Anil , Kayakool Subair , . Vishnusripriya , Chandran Nanditha
Published: October 2023

Atmospheric plasma is the fourth state of matter. Although the natural state of plasma is of higher temperature production of non-thermal atmospheric plasma in laboratory conditions has paved way to its numerous applications in the vast array of disciplines such as food science medicine and dentistry. In the recent years its role in Periodontics and Implantology cannot go unnoticed.