bluuebunny/crossref_metadata_2025 huggingface dataset:
Early hemostatic derangements in patients with de novo acute leukemia: A single center experience
Authors: Laith Alnuaimy Sarah , P. Shamoon Rawand
Published: August 2023

Background and objective: Bleeding and thrombosis are major causes of morbidity and mortality in patients with acute leukemia (AL); they are attributed to hemostatic derangement and coagulation defects that are associated with leukemia. There is a paucity of information regarding coagulopathy in AL patients in our locality; this study, therefore, was employed to evaluate hemostatic parameters in patients with AL at the time of presentation. Methods: This prospective cross-sectional study included 84 newly diagnosed patients with AL. The study was carried out at Nanakali hemato-oncology center from September 2021 to May 2022. Patients were assessed for coagulation parameters including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen level (FBG), D-dimer (D-Di), antithrombin (AT), protein C (PC), and protein S (PS). Results: The median age of the studied patients was 26 years with a male to female ratio of 1.1:1. Acute myeloid leukemia (AML) patients constitutes 51.2% (43 patients), and the remaining 41 (48.8%) patients had acute lymphoblastic leukemia (ALL). PT was significantly prolonged, D-Di was significantly higher and AT, and PC were significantly decreased in AML compared to control groups. Only D-Di level was significantly higher in ALL compared to control groups. Bleeding manifestations were encountered in 40 (47.6%) patients with a higher incidence among the AML group (28 patients, 70%). Thrombosis occurred in 2 (2.4%) patients. Conclusion: Defects of coagulation were common in AL. Hemostatic derangement and bleeding at the time of presentation were more noticeable in patients with AML.
Evaluation of aberrant expression of CD markers in acute leukemia cells
Authors: kareem Shwani Lava , Sadiq Muhammad Nawsherwan , Hassan Hamza Hiwa
Published: August 2023

Background and objective: Worldwide immunophenotyping by flow cytometry (FCM) in acute leukemia (AL) is the golden step in the diagnosis. It’s very common for acute leukemias to aberrantly express antigens or cluster of differentiation (CD) markers which are usually expressed in other lineages of the disease hence this study aimed at determining the prevalence of aberrancy in AL and to find out the frequency of each aberrant CD marker and their association with the clinic-hematological profile of the cases. Methods: Following history and clinical examination of enrolled patients, blood and/or bone marrow aspirate was drawn for morphological examination and immunophenotyping by FCM from 86 newly diagnosed acute leukemia cases then multiple steps procedure was applied followed by interpretation of the results. Results: The prevalence of aberrant phenotype was 46.5%. The proportional frequency of aberrant phenotype in acute myeloid leukemia (AML) was 41%, in B-acute lymphoblastic leukemia (B-ALL) was 48.8% and in T-acute lymphoblastic leukemia (T-ALL) was 66.6%. The commonest aberrant CD markers in AML were CD22 and CD2, in B-ALL were CD66c and CD13 while in T-ALL were CD13 and CD33. The aberrant phenotype harbored lower white blood cell (WBC) count and blast percentage in PB, also splenomegaly was more frequent in lymphoid positive (Ly+) AML and myeloid positive (My+) T-ALL while in B-ALL, splenomegaly was more frequent in myeloid negative (My-) B-ALL. Conclusion: Aberrant phenotype prevalence in our study sample was comparable to other studies, considerable frequency of aberrant markers is present in cases of AL and some variations exist regarding the clinical and hematological profile of the aberrant group.
Characterizations of MnO2 doped TiO2 nanostructures and effective degradation of methylene blue dye under visible light irradition
Authors: Thambidurai R. , Gobi G. , Uthrakumar R. , Inmozhi C. , Kaviyarasu K.
Published: August 2023

Pure and TiO2 doped MnO2 nanoparticles were made using a simple sol-gel technique, and their structural, morphological, characteristics were characteristically examined using XRD, FTIR, and UV-Visible and photocatalytic analysis. Through XRD and SEM analyses, a tetragonal crystalline structure with spherical nanoparticles was discovered. The EDAX experiments provide additional evidence of TiO2's presence in the MnO2 crystal matrix. From UV spectral studies, the band gap energy of MnO2 doped was determined. Photo-degradation study was monitored using methylene blue (MB) and phenol dye solution under visible light irradiation. MnO2 doped catalyst displayed exceptional photocatalytic efficacy towards MB dye under ideal conditions
Synthesis of Ag-modified ZnO/MWCNT nanoparticles and their application as a catalyst in the degradation of methylene blue
Authors: López Alejandro E. M. , Ramírez Morales E. , Arellano Cortaza M. C. , Morán Lázaro J. P. , Pérez Hernández G. , Rojas Blanco L.
Published: August 2023

Ag-ZnO/MWCNT composites were obtained by microwave-assisted, varying-charge synthesis of multiwalled carbon nanotubes (MWCNT). The structural, morphological and optical properties were characterized by: XRD, SEM, TEM, Physisorption of N2 and UVVis. The incorporation of Ag ions and MWNTC caused changes in the structure tension and in the average crystallite size of ZnO. The micrographs revealed that ZnO agglomerates were distributed on the MWNTC and that Ag particles were deposited on the surface of the heterostructure, thus the energy gap decreased. The percentages of degradation of methylene blue were 98 and 75% under ultraviolet and visible radiation, respectively, in the Ag-ZnO/CNT composites.
Comparative analysis of adsorption and release properties of β-phenylethanol on two kinds of activated carbon
Authors: Zhang J. S. , Fang Z. H. , Wang L. , Chen Z. Y. , Zhou Y. , Liang M. , Huang S. J.
Published: August 2023

In order to understand the adsorption and release properties of β-phenylethanol on activated carbon produced from different carbon sources, coconut shell activated carbon (CAC) and petroleum coke activated carbon (PAC) were selected for the immobilization β-phenylethanol. The structure and morphology of CAC and PAC were characterized by SEM, BET and TGA analysis. And then the effect of carbon sources and pore structure on β-phenylethanol adsorption and release properties were investigated by kinetic model. The results showed that the microporosity ratios for CAC and PAC were 89.13% and 77.12%, respectively, and both types of activated carbon were dominated by micropore structure. The adsorption behavior of β-phenylethanol on the CAC and PAC was both controlled by the physical adsorption, and the equilibrium adsorption capacity of CAC (391.2 mg/g) was 45.50% of that of PAC (859.8mg/g). Quasi primary equation can be used to describe the adsorption of β-phenylethanol on both types of activated carbon, i.e., the external transport resistance plays a major role in the adsorption process. The results of thermogravimetric analysis showed that the thermal stability of β-phenylethanol was obviously improved after the immobilization into activated carbon, accompanied with a higher temperature intervals for the release process and a decreased release rate. And the thermal stability of CAC loaded with β-phenylethanol was higher than that of PAC. Furthermore, the sustained release of β-phenylethanol from CAC and PAC was more consistent with the Korsmeyer-Peppas model and was dominated by Fick diffusion. The release rates of β-phenylethanol were 27.34% and 57.57% for CAC and PAC, respectively, under 35 days of storage at room temperature. The higher micropore ratio and lower mean pore width of CAC were responsible for the good stability and sustained release properties of immobilized β-phenylethanol.
Exfoliated carbon nitrides for corrosion prevention in radiators: Temperature-dependent corrosion analysis
Authors: Vasudevan D. , Kumaravel A. , Murugesan A. , Mugil A. , Karthi B. , Kumar K. K.
Published: August 2023

This article outlines the preparation and exfoliation of graphitic-carbon nitride (GCN) by thermal polymerization technique using urea proceeded by the hydrothermal approach for the application of corrosion resistance in radiators. The prepared sample was characterized by using various methods. X-ray powder diffraction (XRD) and Fourier-transform infrared spectroscopy (FT-IR) confirmed the purity of GCN, and Surface morphology results revealed the formation of spherical-shaped GCN. Herein, graphitic carbon nitride (GCN) was synthesized to enhance its corrosion-resistance performance on mild steel (MS) under a seawater atmosphere. The corrosion behaviour of the graphitic-carbon nitride (GCN) synthesized by the hydrothermal method was examined by conducting electrochemical corrosion tests in a 3.5% NaCl medium under three different temperatures. The excellent temperature dependant electro-catalytic activity of the prepared GCN was analysed. The hydrothermal exfoliation process highly enhances the structural, optical, and electrochemical properties like corrosion resistance and stability of the prepared GCN. This study demonstrates that hydrothermally exfoliated GCN exhibits low corrosion rates and high electrochemical corrosion resistance, which could be a potential candidate for corrosion inhibitors in radiators.
Al-ions effect on structural, optical, antibacterial, and photocatalytic activities of ZnO nanostructures
Authors: Ullah Z. , Qureshi M. T. , Sultana K. , Ullah F. , Khalid A. , Masood N. , Abdella F. I.A. , Elhag S. A.
Published: August 2023

In this work, Pure and aluminum doped zinc oxide nanostructures were successfully synthesized through a well-established hydrothermal method. The hexagonal wurtzite structure, and nano porous shape for Al dopant in ZnO were confirmed via XRD and SEM analysis. The reduction in energy band gap (3.40 to 3.19 eV) for Al dopant samples and enhancement in inhibition zones (7 mm- 17 mm) for pure and Al-doped ZnO were recorded. The photocatalytic activity of Al doped ZnO was shown to be several times more efficient than in prior studies. The enhancement in these parameters suggest that these materials are good candidates for biomedical and optoelectronic applications.
Biosynthesis and characterization of copper nanoparticles with andrographis paniculata for antimicrobial applications
Authors: Tamil Selvi E. , Uthrakumar R. , Inmozhi C. , Kaviyarasu K.
Published: August 2023

This study presents a synthesis of copper nanoparticles in which an intermediate aqueous extract of the leaves of Andrographis paniculata. The synthesis copper nanoparticles (CuNPs) was supervised by UV-visible spectroscopy at room temperature. FTIR analysis prepared nanoparticles exhibited the attendance of comparable peaks established in the leaves extract spectra. XRD analysis inveterate the crystalline structure of synthetic copper nanoparticles. SEM's images presented that greatest balls were a spherical, like a shaped one. Subsequently, CuNPs was further analyzed for anti-bacterial effects from the Gram positive and Gram negative was obviously detected.
Queuosine‐tRNA promotes sex‐dependent learning and memory formation by maintaining codon‐biased translation elongation speed
Authors: Cirzi Cansu , Dyckow Julia , Legrand Carine , Schott Johanna , Guo Wei , Perez Hernandez Daniel , Hisaoka Miharu , Parlato Rosanna , Pitzer Claudia , van der Hoeven Franciscus , Dittmar Gunnar , Helm Mark , Stoecklin Georg , Schirmer Lucas , Lyko Frank , Tuorto Francesca
Published: August 2023

Queuosine (Q) is a modified nucleoside at the wobble position of specific tRNAs. In mammals, queuosinylation is facilitated by queuine uptake from the gut microbiota and is introduced into tRNA by the QTRT1‐QTRT2 enzyme complex. By establishing a Qtrt1 knockout mouse model, we discovered that the loss of Q‐tRNA leads to learning and memory deficits. Ribo‐Seq analysis in the hippocampus of Qtrt1‐deficient mice revealed not only stalling of ribosomes on Q‐decoded codons, but also a global imbalance in translation elongation speed between codons that engage in weak and strong interactions with their cognate anticodons. While Q‐dependent molecular and behavioral phenotypes were identified in both sexes, female mice were affected more severely than males. Proteomics analysis confirmed deregulation of synaptogenesis and neuronal morphology. Together, our findings provide a link between tRNA modification and brain functions and reveal an unexpected role of protein synthesis in sex‐dependent cognitive performance.
Vascular endothelial mineralocorticoid receptors and epithelial sodium channels in metabolic syndrome and related cardiovascular disease
Authors: Jia Guanghong , Hill Michael A , Sowers James R
Published: August 2023

Metabolic syndrome is a group of risk factors that increase the risk of developing metabolic and cardiovascular disease (CVD) and include obesity, dyslipidemia, insulin resistance, atherosclerosis, hypertension, coronary artery disease, and heart failure. Recent research indicates that excessive production of aldosterone and associated activation of mineralocorticoid receptors (MR) impair insulin metabolic signaling, promote insulin resistance, and increase the risk of developing metabolic syndrome and CVD. Moreover, activation of specific epithelial sodium channels (ENaC) in endothelial cells (EnNaC), which are downstream targets of endothelial-specific MR (ECMR) signaling, are also believed to play a crucial role in the development of metabolic syndrome and CVD. These adverse effects of ECMR/EnNaC activation are mediated by increased oxidative stress, inflammation, and lipid metabolic disorders. It is worth noting that ECMR/EnNaC activation and the pathophysiology underlying metabolic syndrome and CVD appears to exhibit sexual dimorphism. Targeting ECMR/EnNaC signaling may have a beneficial effect in preventing insulin resistance, diabetes, metabolic syndrome, and related CVD. This review aims to examine our current understanding of the relationship between MR activation and increased metabolic syndrome and CVD, with particular emphasis placed on the role for endothelial-specific ECMR/EnNaC signaling in these pathological processes.
Домішки впровадження у сплавах зі структурою В19
Authors: Zaginaichenko S.Yu. , Matysina Z.A. , Zolotarenko An.D. , Shvachko N.A. , Zolotarenko Ol.D. , Rudakova E.P. , Akhanova N.Y. , Ualkhanova M. , Schur D.V. , Gabdullin M.T. , Myronenko T.V. , Zolotarenko A.D. , Chymbai M.V. , Dubrova O.E.
Published: August 2023

У роботi розглянуто метал з гексагональною структурою В19, в мiжвузля якого впроваджуються атоми. Методом конфiгурацiй вивчено розчиннiсть впроваджених домiшок та параметри кореляцiї у замiщеннi вузлiв i мiжвузлiв, знайдено їх залежнiсть вiд складу металу, температури та ступеня дальнього порядку у вузлах. Знання параметрiв кореляцiї дозволяє оцiнити багато фiзичних характеристик сплавiв. Якщо ж параметри кореляцiї вiдомi з експериментiв, отриманi формули дозволяють визначити енергетичнi параметри сплавiв, що має наукову цiннiсть.
Dakwah Humanis: Studi tentang Etika Sosial Nurcholish Madjid
Authors: Masturi Ade , Utami Asih Dewi
Published: August 2023

Agama selama berabad-abad sering terseret jauh dari misi moralnya yang mulia dan luhur sehingga berubah menjadi sumber kebencian, permusuhan, dan peperangan. Berangkat dari analisis historis seperti ini, muncul sebuah seruan untuk mengembalikan agama kepada misi aslinya seperti disuarakan oleh para pembawanya, untuk kemanusiaan, untuk menampilkan wajah aslinya, wajah humanis, wajah ramah. Melihat kenyataan ini, tampak dakwah menghadapi tantangan yang tidak ringan. Ketika dakwah diartikan sebagai transformasi sosial, dakwah akrab dengan teori-teori perubahan sosial yang mengasumsikan terjadinya progress (kemajuan) dalam masyarakat. Agama yang dibutuhkan oleh umat manusia setiap zaman adalah agama yang humanis. Doktrin, paham, atau gerakan yang bertujuan meningkatkan harkat dan martabat manusia disebut humanisme. Sementara humanisme dalam Islam dipahami sebagai sebuah gerakan yang mempunyai spirit egaliter. Nurcholish Madjid termasuk tokoh yang giat menyuarakan pesan Islam yang damai, ramah dan sejuk. Ia dianggap lebih kontekstual dalam memahami doktrin-doktrin agama, dan pesan-pesan keagamaannya dianggap lebih humanis.Pemikiran Madjid yang tertuang dalam pesan-pesan dakwahnya yang berorientasi pada etika sosial khususnya menyangkut hubungan agama, baik internal dan eksternal agama, lebih spesifik lagi menyangkut persaudaraan, toleransi, keadilan sosial dan lain-lain, dapat dilacak dari ide-idenya tentang pembaruan pemikiran dalam Islam.
Gerakan Islam: Problem Ideologi Radikal, Global Jihad dan Terorisme Keagamaan
Authors: Tasman Tasman , Aisyah Aisyah
Published: August 2023

Dalam beberapa dasawarsa terakhir, peta dunia ditandai dengan gerakan Islam radikal. Meskipun agama bukan satu-satunya faktor, gerakan tersebut jelas banyak dipengaruhi (paham) agama. Misalnya tragedi serangan atas WTC 11 September 2001. Aksi terorisme ini dilancarkan oleh fundamentalisme (Islam) radikal yang menghalalkan segala cara untuk melawan kepentingan Amerika Serikat, Barat, dan modernitas beserta nilai-nilai yang dibawanya (HAM, demokrasi, liberalisme, dan lain-lain). Di Indonesia sendiri, kita juga melihat berbagai fenomena keagamaan yang seperti membenarkan asumsi bahwa fundamentalisme memang sedang mengukuhkan keberadaannya, fundamentalisme radikal sedang bangkit. Misalnya terjadi peristiwa peledakan bom Bali dan bom Mariot di Jakarta. Gerakan radikal mendapat perhatian utama di kalangan pengamat politik global sebagaimana dilansir oleh Karen Armstrong yang menyatakan: bahwa di abad 20 (dan berlanjut di abad 21) fundamentalisme sedang bangkit di setiap agama-agama besar (major religion) dan merupakan sebentuk revolusi yang tersebar luas di seluruh penjuru dunia melawan modernitas dan masyarakat sekular. Persoalannya adalah apakah gerakan radikal tersebut sesuai dengan karakter dan watak Islam? Jawaban terhadap pertanyaan ini tentu saja tidak mudah apalagi menempelkan istilah radikal kepada agama tertentu. Oleh karena itu, tulisan ini mencoba mengurai pengertian Gerakan Islam:, radikalisme, jihad, dan terorisme berbasis Agama. Kajian ini akan memfokuskan pada fenomena gerakan Islam kontemporer, pasca tahun 2000.
Keterwakilan Perempuan di Parlemen Mendorong Kebijakan Perlindungan Perempuan Terhadap Kekerasan
Authors: Anis Farida  , Afif Hidayatul Mahmudah  , Priyo Handoko
Published: August 2023

Keterwakilan perempuan di parlemen diharapkan dapat melahirkan kebijakan yang berpihak pada perempuan. Harapan besar tersebut juga diamanatkan pada anggota legislatif perempuan di DPRD Jawa Timur. Artikel ini mengangkat isu hukum,  tentang keterwakilan perempuan anggota Legislatif dalam proses legislasi yang melahirkan kebijakan  perlindungan  perempuan dari tindak kekerasan. Untuk menjawab isu hukum tersebut digunakan metode penelitian hukum empiris dengan pendekatan socio legal studies. Hasil penelitian ini menunjukkan bahwa keterwakilan perempuan di DPRD Jawa Timur menghasilkan kebijakan yang berpihak pada perempuan, yaitu melalui produk hukum yang memberikan perlindungan terhadap perempuan dari tindak kekerasan yang semakin meningkat di masa pandemi covid-19. Proses legislasi yang dilakukan oleh anggota legislatif perempuan dalam melahirkan kebijakan perlindungan perempuan tidak lepas dari  hambatan budaya patriarki yang masih kuat di masyarakat; keterbatasan anggaran; serta minimnya keterwakilan perempuan di parlemen. Peran keterwakilan perempuan sangat dibutuhkan dalam meningkatkan IDG di Jawa Timur dalam mewujudkan demokrasi yang berkeadilan gender.
Kepemimpinan Perempuan Yogyakarta Menurut Putusan Mahkamah Konstitusi Nomor 88/PUU-XIV/2016 dan Kepemimpinan Dalam Islam
Authors: Nisvi Dwi Sakiya , Junianto  , Firyal Afifah Huda  , Moh. Khoirul Umam
Published: August 2023

Persyaratan untuk menjabat sebagai Gubernur DIY diatur dalam pasal 18 ayat (1) huruf m Undang-Undang No. 13 Tahun 2012 tentang Keistimewaan Daerah Istimewa Yogyakarta. Rumusan dalam pasal tersebut dinilai diskriminatif karena secara tersurat ada frasa “istri” yang menimbulkan tafsir bahwa jabatan Gubernur maupun Wakil Gubernur selalu seorang laki-laki. Artikel ini mengajukan isu hukum tentang putusan MK No 88/PUU-XIV/2016 tentang kepemimpinan politik perempuan di DIY dalam perspektif hukum positif dan perspektif sejarah Islam. Jenis penelitian yang digunakan adalah penelitian hukum normatif dengan pendekatan perundang-undangan, pendekatan kasus dan pendekatan sejarah.  Hasil dari penelitian ini menunjukkan bahwa Pasal 18 ayat (1) huruf m UU No. 13 Tahun 2012 menimbulkan pro dan kontra sehingga dalam Putusan Mahkamah Konstitusi Nomor 88/PUU-XIV/2016 memberikan koreksi tentang frasa istri, sehingga dengan dihilangkannya frasa istri, maka laki-laki atau perempuan dapat menjabat sebagai Gubernur DIY.  Sedangkan menurut kepemimpinan dalam Islam pembatasan pemimpin tidak sesuai dengan perkembangan zaman dan jika ditinjau dari berbagai syarat-syarat imam tidak ada larangan seorang perempuan menjadi pemimpin.
Penegakan Hukum Terhadap Pelanggar Protokol Kesehatan Pada Masa Pandemi Covid-19
Authors: Maulidah Faizah , Farida Anis , Yahya Khoirul , Saifullah Hafizh Itsaar
Published: August 2023

Kesadaran hukum untuk taat pada protokol kesehatan merupakan sebuah keniscayaan yang harus dilaksanakan setiap individu yang mengutamakan kesehatan di masa pandemi Covid-19. Pemerintah dalam mengupayakan dan menjaga keselamatan rakyat di masa Pandemi Covid-19 dengan cara menegakkan berbagai peraturan dan menjatuhkan berbagai sanksi. Adagium keselamatan rakyat adalah hukum tertinggi (Salus Populi Suprema Lex Esto) idealnya dijadikan pedoman utama, bahkan menjadi prinsip dasar bagi semua komponen bangsa Indonesia dalam menjalani kehidupan sehari-hari di masa pandemi covid-19. Namun kenyataannya di masyarakat, kesadaran untuk taat pada hukum tersebut sering kali diabaikan, sehingga tidak mengherankan manakala dilakukan razia, akan terdapat banyak anggota masyarakat yang terjaring dan harus menjalani sidang. Penelitian ini merupakan penelitian hukum empiris dengan menggunakan pendekatan sociological jurisprudence. Penelitian ini dilakukan di Kabupaten Sidoarjo dikarenakan pemerintah setempat cukup intensif dalam melakukan penegakan hukum bagi para pelanggar protokol kesehatan. Penelitian ini akan mengkaji lebih mendalam terkait komitmen pemerintah daerah Sidoarjo dalam menggelar razia, menyidangkan, dan menjatuhkan sanksi kepada para pelanggar protokol kesehatan. Para pelanggar protokol kesehatan mempunyai berbagai alasan untuk menunjukkan bahwa tindakannya benar. Ketidakmampuan membeli masker sering kali dikemukakan sebagai alasan, demikian pula ketika mereka berada di sekitar tempat tinggalnya juga merasa tidak perlu menggunakan masker. Dengan adanya rutinitas penegakan protokol kesehatan, serta penindakan, dapat menurunkan angka pelanggaran terhadap protokol kesehatan.
TFR1-Mediated Iron Metabolism Orchestrates Tumor Ferroptosis and Immunity in Non-Small Cell Lung Cancer
Authors: Wang Zunqiao , Yao Xingkai , Wang Keping , Wang Bin
Published: August 2023

This study aimed to investigate the underlying molecular mechanisms of transferrin receptor (TFR1) in non-small cell lung cancer (NSCLC). Histological analysis was performed using hematoxylin-eosin (HE) staining. The number of CD8+ T cell were determined by flow cytometry and immunofluorescence assays. mRNA levels were analyzed by qRT-PCR. Protein expression was detected by western blot. Ferroptosis was detected by using propidium iodide (PI) staining. Xenograft experiment was applied for determining tumor growth. The results showed that interferon (IFN)-γ plus iron dextran (FeDx) induced iron overload and the ferroptosis of NSCLC cells. Moreover, IFN-γ-mediated upregulation of TFR1 promoted ferritinophagy and tumor cell ferroptosis via blocking via blocking ferritin heavy chain 1 (FTH1)/ ferritin light chain (FTL) signaling. However, TFR1 knockout suppressed the ferroptosis of tumor cells. Furthermore, FeDx-mediated iron overload promoted the sensitivity of anti-programmed death ligand 1 (PD-L1) therapies. Clinically, TFR1 was downregulated in NSCLC patients. Low levels of TFR1 predicted decreased CD8+ T cells. Taken together, IFN-γ combined with iron metabolism therapies may provide a novel alternative for NSCLC.
Data Integrity as a Code (DIAC)
Authors: Sasidhar (Sunny) Duggineni
Published: August 2023

Data integrity is critical in many industries, including healthcare, finance, and manufacturing. It involves maintaining the accuracy, completeness, and consistency of data throughout its lifecycle. Data Integrity as a Code (DiaC) is an approach that uses programming techniques to enforce data integrity principles. This chapter will explore the concept of DiaC and its benefits in ensuring data integrity.
Development of the Clinical Interview for Bipolar Disorder (CIBD) – Rational and experts’ panel evaluation
Authors: Julieta Azevedo , Paula Castilho , Diogo Carreiras , Maria João Martins , Célia Barreto Carvalho , Sónia Cherpe , Ana Telma Pereira , António Macedo
Published: August 2023

Bipolar Disorder (BD) is underdiagnosed, and the average time gap between the onset and diagnosis due to poor screening is 7 years. This study aims to describe the development of the semi-structured Clinical Interview for Bipolar Disorder (CIBD) for diagnosing bipolar spectrum disorders and assessing the impact of psychological interventions, using a mixed method approach of clinician and interviewee ratings, with a recovery approach. Methods: CIBD was based on DSM-5 and developed by a multidisciplinary team. Firstly, a research review on BD assessment was conducted, and published guidelines from international BD experts were incorporated into the interview. Secondly, an expert panel formed by 9 psychiatrists, 8 psychologists, a nurse, and a neuropsychologist with expertise in BD was asked to assess it for clarity, pertinence, and completeness. Results: CIBD structure and sections were rated with high scores (range: 0-80) regarding usefulness (78.63), clarity (74.53), and completeness (77.63). The expert panel gave suggestions to clarify, add and change some instructions in the introduction, suicide risk scale for BD, and the empowerment scale, and an index was also added to help navigate the interview. Conclusion: CIBD is an acceptable and comprehensive tool for assessing BD and related disorders contributing to a recovery perspective and might be useful for tracing intervention improvements. Experts highlight the CIBD’s unique contributions, including the suicidality scale encompassing BD-specific risk factors, BD specifiers, and the assessment of clients’ empowerment. Overall, the CIBD seems to be a promising innovative instrument for diagnosing and assessing BD.
U54 SCENT Adult Colonoscopy Tissue Collection Procedure v1
Authors: Garman Katherine
Published: August 2023

This protocol outlines the inclusion and exclusion criteria as well as collection and processing of adult colon tissue at Duke University
[RETRACTED] Can light be used to treat obesity and diabetes? v3
Authors: Daoudi Rédoane
Published: August 2023

[RETRACTED]

This document is highly theoretical lab method paper. It may be used to perform thermogenesis from several cells in a living organism instead of only brown adipocytes. We perform thermogenesis from white adipocytes. The purpose is to uptake the blood glucose and lipids to produce heat and subsequent weight loss and to diminish blood glucose levels for people who suffering from diabetes and obesity. In fact thermogenesis consumes energy (i.e blood glucose and blood lipids). So we now describe a novel and original lab method based on thermogenin (called thermogenin-like system, UCP1-like system or TLS) that is involved in heat production and glucose/lipids capture by white adipocytes.
YÜKSEKÖĞRETİM ÖĞRENCİLERİNİN DEPREM SONRASINDA ÇEVRİMİÇİ CANLI DERSLERDEKİ MOTİVASYON KAYNAKLARI VE SORUNLARI
Authors: Şahin Kölemen Cansu
Published: August 2023

Motivasyon, kişiyi eyleme geçiren, gerçekleştirdiği eylemi sürdürmesine sebep olan bir durumdur. Bireyin içinde bulunduğu duruma göre motivasyonunu arttıran ya da azaltan birçok etken bulunmaktadır. Birey motivasyonsuz olduğu zamanlarda davranışı gerçekleştirmek istememektedir. Bu sebeplerden biri bu eylemin kendisine fayda sağlamayacağı düşüncesinin hâkim olmasıdır. Buna ek olarak bireylerin tekrarladığı davranışların, sonuçlarında tutarsızlık görmesiyle birlikte motivasyonları da düşmektedir. Bireylerin motivasyona ihtiyaç duyduğu alanlardan biri öğrenme sürecidir. Çünkü öğrenme sürecinde öğrencilerin öğrenme isteği farklı motivasyon kaynaklarından etkilenmektedir. 6 Şubat’ta yaşanılan deprem sonrası ani bir karar ile uzaktan eğitime geçilerek dersler çevrimiçi canlı olarak yürütülmektedir. Bu süreçte öğrencilerin öğrenme sürecine dair motivasyonu olumlu ya da olumsuz bir şekilde etkilendiği söylenebilir. Bundan dolayı bu çalışmanın amacı öğrencilerin deprem sonrası çevrimiçi canlı derslere yönelik motivasyon kaynaklarını ve sorunlarını ortaya koymaktır. Çalışmanın amacına uygun olarak nitel araştırma yöntemlerinden durum çalışması tercih edilmiştir. Çalışma grubu amaçlı örneklem yöntemiyle oluşturulmuştur. Ayrıca çalışma grubu 2022-2023 eğitim-öğretim yılının güz dönemini örgün eğitimle tamamlayıp bahar dönemini uzaktan eğitim ile yürüten 19 yükseköğretim öğrencilerinden oluşmaktadır. Veri toplama aracı olarak görüşmelerden faydalanılmıştır. Görüşme sürecinde yarı yapılandırılmış görüşme formu kullanılmıştır. Görüşme formu demografik bilgilerden ve üç sorudan oluşmaktadır. Elde edilen veriler nitel veri analiz yaklaşımlarından içerik analizi ile çözümlenmiştir. Çalışmanın sonucunda öğrencilerin içsel ve dışsal motivasyon kaynakları belirlenerek, motivasyonsuzluğa sebep olan durumlar ortaya konulmuştur. Bu motivasyonsuzları ortadan kaldırmak adına önerilerde bulunulmuştur.
Power generation system on Saturn’s Titan moon using geothermal energy
Authors: Voronov Vladimir A. , Zharov Anton A. , Apsit Konstantin A.
Published: August 2023

BACKGROUND: Because Saturns satellite, Titan, is of particular research interest with respect to planning future missions, considering the issue of power generation on the surface of Titan is necessary. This study shows that the use of geothermal sources is one of the most promising methods of generating electricity on Titan.
AIM: The purpose of the study is to explore the best way to utilize geothermal energy from the surface of Titan.
METHODS: Therefore, energy installations operating according to the precritical Rankine, postcritical Rankine, two-cascade Rankine, and Brighton cycles were investigated in this study. The selection of working fluids for these cycles would be based on the fluids present in the atmosphere of Titan to reduce the amount of materials transported from Earth. The power cycle efficiencies for different working fluids, degree of preturbine steam superheating, and pressures were calculated to enable the comparison of the maximum possible efficiency for each cycle under conditions equivalent to those on Titan.
RESULTS: In general, the calculations herein revealed that all cycles under consideration are feasible under the given conditions. Notably, a simple precritical Rankine cycle with methane as the working fluid exhibits the highest efficiency under the given conditions.
Seismogenic Structure of the Hidden Haicheng Fault System in China Revealed by Seismic Observations from 2008 to 2018
Authors: Zhang Pengda , Dai Zhiyang , Yang Shichao , Zha Xianjie
Published: August 2023

The hidden Haicheng fault system is an earthquake-prone zone on the Liaodong Peninsula, China. Its seismogenic structure is still unclear and needs further study. In this study, we used the differential evolution algorithm to invert the waveform data of the 2008 ML 4.8 Haicheng earthquake and the 2012 ML 4.8 Gaizhou earthquake and obtained an updated 1D crustal velocity model. The model reveals a low-velocity zone with a depth of 18–24 km below the Haicheng fault zone. Based on the velocity model, we used the arrival-time data to accurately locate the earthquakes that occurred in the Haicheng area from 2008 to 2018. The relocated earthquakes show that the Az 300°-trending Haicheng fault consists of two segments spaced about 2 km apart, namely the western and the eastern segments. They are about 12 and 22 km long and inclined to the northeast with dips of 70° and 80°, respectively. These seismogenic structures of the Haicheng fault zone are important for assessing the future seismic risk in the region.
Investigation of Site Characterization and Vulnerability in Antakya (Turkey) under Basin Effect
Authors: BÜYÜKSARAÇ Aydın , BEKTAŞ Özcan , IŞIK Ercan , ÖVER Semir , KAÇIN Selçuk
Published: August 2023

It is very important and necessary to know the depth of the bedrock in determining the soil behavior. However, determining the depth of bedrock spatially is a very difficult and costly process. The depth of the bedrock can be obtained by using the dominant vibration frequency obtained by the microtremor data. The bedrock depth map was created with the correlation produced from the dominant vibration frequencies obtained from microtremor measurements made in Antakya (Turkey). In bedrock calculations at low frequencies, the value range shows scattering. In the vulnerability analysis for Antakya soils, a low level of vulnerability (Kg = 6) was obtained in the east and northeast of the area. It has been observed that the S-wave velocity (Vs) in this area is lower than 406 ms-1. In this case, this value has been accepted as the vulnerability threshold value in Antakya soils. Peak Ground Acceleration (PGA) and Peak Ground Velocity (PGV) were obtained for each location by using earthquake ground motion levels with 2%, 10%, 50%, and 68% probability of exceedance in 50-year periods. The PGA values in the region range from 0.43 to 0.47 g for earthquakes with a return period of 475 years.
A Class of Skew-Cyclic Codes over (Z_(2^m ) [u])/〈u^2-r〉 with Derivation
Authors: ÖZİMAMOĞLU Hayrullah
Published: August 2023

Let R_r=Z_(2^m )+uZ_(2^m ) be a finite ring, where u^2=r for r∈Z_(2^m ), m is a positive integer, and m≥2. In this paper, we study a class of skew-cyclic codes using a skew polynomial ring over R_r with an automorphism θ_r and a derivation δ_(θ_r ). We generalize the skew-cyclic codes over Z_4+uZ_4; u^2=1 to the skew-cyclic codes over R_r, and call such codes as δ_(θ_r )-cyclic codes. We investigate the structures of a skew polynomial ring R_r [x,θ_r,δ_(θ_r ) ]. A δ_(θ_r )-cyclic code is showed to be a left R_r [x,θ_r,δ_(θ_r ) ]-submodule of (R_r [x,θ_r,δ_(θ_r ) ])/〈x^n-1〉 . We give the generator matrix of a δ_(θ_r )-cyclic code of length n over R_r. Also, we present the generator matrix of the dual of a free δ_(θ_r )-cyclic code of even length n over R_r.
On Existence and Uniqueness of Some Fractional Order Integro-Differential Equation
Authors: CONA Lale , BAL Esmahan
Published: August 2023

In this study, a sufficient condition for the existence and uniqueness of some fractional order Integral-Differential equations is obtained. Therefore, the fixed point method is used to solve the differential equation problem involving nonlinear degree integrals. In addition, the results found is supported by examples.
Synthesis and Characterization of Terpolymer Adsorbents Using Photopolymerization: Investigation of Heavy Metal Adsorption Capacity
Authors: MURAT SALTAN Gözde
Published: August 2023

In this study, poly(allylphenol-co-methylmethacrylate-co-vinyl imidazole) (PAMV) terpolymer adsorbents were synthesized using the photopolymerization method with 1-vinyl imidazole, methyl methacrylate, and 2-allylphenol monomers. Structural and surface analyzes of PAMV polymers obtained using different mole ratios 1H-Nuclear Magnetic Resonance, Fourier-Transform Infrared Spectroscopy, X-Ray Photoelectron Spectroscopy, Scanning Electron Microscopy-Energy Dispersive X-Ray and thermal characterization were performed using Thermogravimetry methods. Inductively Coupled Plasma Mass Spectrometry was used for adsorption studies. Optimization studies were carried out at different pH values. According to the results obtained, the pH range in which adsorbents operate at maximum efficiency is between 6-10. Although many different metals have been studied, the holding capacity of the obtained polymeric adsorbent on cadmium, chromium and mercury metal ions is quite remarkable.
Changes in Salivary Fluoride Levels with a 2-minute Toothbrush Timer
Authors: Prihastari Lisa , Rosdi Ramdha Al Farabi , Rintoko Bimo
Published: August 2023

The duration of tooth brushing deserves special attention since it is a factor that affects oral hygiene. The recommended duration for tooth brushing is 120 seconds, yet many people do not follow this suggestion. The relationship between the duration of tooth brushing and the fluoride level in saliva after brushing is still debatable. The study aims to determine the effectiveness of brushing teeth for 2 minutes on fluoride levels in the saliva of children aged 7-8 years. This experiment employed a pretest-posttest design with the control group. This single-blind study involved students from SDN 03 Pagi Pasar Minggu as a group with a manual toothbrush (control group) and SDN 19 Cempaka Putih as a group brushing teeth with a timer (intervention group), each of which consisted of 20 students selected using simple random sampling. Measurement fluoride level in saliva using UV-VIS Spectrophotometer TECAN Infinite M200 Pro®. The study lasted for approximately 3 weeks. The results of the independent t-test indicated no significant difference in fluoride levels between the intervention and the control group (p0.05), although the mean score of the intervention group was higher than the control group. In conclusion, a 2-minute toothbrush timer had the same ability as a manual toothbrush to increase the fluoride level in the saliva of children aged 7-8 years.
ACE Inhibitors-Induced Skin Reaction: A Case Report
Authors: Ezzahraoui R. , Salmi N. , Ouartassi H. El , Bourouhou Z. , Cherti M.
Published: August 2023

Angiotensin-converting enzyme (ACE) inhibitors are widely used as antihypertensives, remodeling agents in heart failure, to stop the progression of diabetic nephropathy, as well as for a variety of other clinical purposes. Some side effects of ACE inhibitors are well recognized such as dry cough, hypotension, hyperkaliemia, proteinuria, renal failure. Also, these substances are known to have a wide range of dermatological side effects in addition to their adverse effects on other systems. (1,2)
We report the case of a 46-year-old man treated for dilated cardiomyopathy with severe left ventricle dysfunction, who developed a cutaneous reaction secondary to the introduction of an ACE inhibitor.
Managing Helicobacter pylori infection: transitioning from conventional to alternative treatment approaches
Authors: ÖCAL Serhat
Published: August 2023

Helicobacter pylori, an essential constituent of the gastric microbiome in those infected, is commonly associated with medical conditions such as chronic gastritis, peptic ulcer disease, and gastric cancer. In recent years, the growing resistance to antibiotics worldwide has emerged as a substantial hurdle in the effective treatment of H. pylori infection. Consequently, it has necessitated the exploration of innovative treatment strategies aimed at bolstering the potency of existing antibiotic-based eradication therapies. Such avant-garde strategies include the incorporation of probiotics and prebiotics as complementary measures to H. pylori treatment, the use of antimicrobial peptides as potential replacements for traditional antibiotics, and the application of photodynamic therapy via ingestible devices. Other advanced methodologies entail deploying drug delivery systems that utilize microparticles and nanoparticles, the invention of vaccines, the exploration of natural products, and the potential use of phage therapy. This review offers a contemporary synopsis of these burgeoning strategies designed to suppress H. pylori, delving into their strengths, hurdles, and aspects to consider during their development. A significant achievement would be the creation of an efficient human vaccine; however, previous attempts at developing such vaccines have met with obstacles or even cessation. Numerous natural products have displayed anti-H. pylori properties, predominantly in laboratory environments. Nonetheless, a requirement remains for more extensive clinical studies to fully comprehend their role in exterminating H. pylori. Finally, phage therapy, while demonstrating potential as a suitable alternative, grapples with considerable challenges, chiefly the isolation of highly virulent bacteriophages that specifically target H. pylori.
OS APINAJÉ E O ISOLAMENTO SOCIAL
Authors: Conceição Wellington da Silva
Published: August 2023

Antes do distanciamento e isolamento social por conta do Covid-19, investigávamos - em Tocantinópolis (TO) - a circulação dos indígenas Apinajé pelos comércios da cidade e a presença de alguns como moradores de um povoado rural, em posição intermediária entre a área de reserva indígena e a cidade. Diante dos desafios impostos pela pandemia, a presença dos indígenas na área urbana e rural da cidade sofreu profundas alterações, e tomaram grande importância em nossa investigação. O problema explorado nesse artigo é a compreensão dos efeitos da pandemia do coronavírus nos trajetos e nas relações interétnicas dos Apinajé em Tocantinópolis, que já apresentavam um processo marcado por tensões. Partindo da premissa de que os grupos sociais mais vulneráveis sofreram com maior drasticidade as consequências da pandemia, os dados em nossa pesquisa nos permitiram registrar como isso se deu na dinâmica de um povo indígena na região norte do Brasil. Nossos objetivos foram descrever como esse processo se configurou na relação dos Apinajé com os demais citadinos, assim como identificar as resistências e demais formas de enfrentamentos por parte desse povo para garantir sua sobrevivência diante de tal evento, mantendo assegurada sua circulação pela cidade. Trata-se de uma pesquisa de caráter etnográfico, com recurso a entrevistas
A ROTA DO FIM DO MUNDO
Authors: Duarte Joana das Flores
Published: August 2023

O presente artigo é resultado de uma pesquisa concluída sobre mercado global de drogas, trabalho, informalidade e a situação de homens e mulheres brasileiros e estrangeiros presos na tipificação penal da Lei 11.343, de 2006. Estruturado em três partes, na primeira objetiva-se situar o caráter qualitativo e quantitativo da pesquisa, ao privilegiar o uso de dados abertos de fontes nacionais e internacionais e a análise marxista dialógica do discurso para o exame das entrevistas semiestruturadas. Em seguida, busca- se desvendar as relações entre fluxos, rotas e conflitos geopolíticos desencadeados pelo mercado global da cocaína e a atuação estratégica da América do Sul e da região Amazônica no setor de produção e exportação para a Europa e África. Nas considerações finais, faz-se apontamentos sobre a tríade: regularização, descriminalização e legalização como responsabilidade do Estado
LUTA E RESISTÊNCIA NA PRODUÇÃO DOS ATINGIDOS POR GRANDES PROJETOS EM BARCARENA, NO PARÁ
Authors: Rodrigues Robert Damasceno Monteiro , Reis Junior Leandro Passarinho , Lemos Flávia Cristina Silveira
Published: August 2023

Este artigo tem como objetivo apresentar um recorte de uma análise sobre o modo como são produzidos os atingidos por grandes projetos no município de Barcarena, no estado do Pará, o que pode ser observado a partir de reflexões, histórias, apontamentos e experiências dos próprios atingidos em relação aos seus processos de luta e resistência. A produção dos atingidos é concebida na perspectiva da psicologia social crítica e, portanto, fundamenta-se nos pressupostos do materialismo histórico-dialético, por considerar os sujeitos como produtores da história e da realidade e, deste modo, de si próprios. Ao analisar as transformações nos modos de vida dos atingidos, o artigo conclui que é um conjunto de fatores sociais, econômicos, ideológicos, objetivos e subjetivos, macro e microestruturais que se articulam para determinar a produção dos atingidos na medida em que eles lutam e resistem contra os grandes projetos.
Puzles en dispositivos móviles como herramienta de apoyo al aprendizaje de fundamentos de programación
Authors: Cela Ingrid , Rodríguez Manne , Erazo Orlando , Chávez Betty
Published: August 2023

Existe una búsqueda constante de más y nuevas herramientas que ayuden a enfrentar la problemática que implica fomentar la motivación para adquirir conocimientos y desarrollar habilidades en áreas o asignaturas complejas como lo es la programación. Una opción son los juegos serios, que se han convertido en una herramienta cada vez más utilizada en educación como un apoyo al proceso de enseñanza-aprendizaje, ayudando a los estudiantes a adquirir o reforzar los conocimientos de las asignaturas de manera entretenida. Con esta referencia, en este trabajo se propone el uso de puzles como un apoyo en el aprendizaje de los fundamentos de programación. Para ello, se diseñó un prototipo de juego serio basado en puzles para dispositivos móviles. El prototipo fue evaluado con la participación de estudiantes que cursaban un primer nivel de programación. Los resultados de esta evaluación fueron positivos, sugiriendo los participantes que el prototipo era atractivo y fácil de utilizar. Esto permite concluir que el empleo de puzles en dispositivos móviles al aprender programación por primera vez es una idea válida que puede apoyar el aprendizaje.
Importancia de la interculturalidad en la enseñanza de idiomas extranjeros y la adaptación cultural
Authors: Estupiñán Lince María Lorena , Galarza Pucha Jairo Patricio
Published: August 2023

Este trabajo sobre la comunicación intercultural contiene ejemplos de tradiciones de diversas culturas y experiencias de estudiantes internacionales que ilustran la forma en que es comprendido el mundo y la urgente importancia de la enseñanza de la interculturalidad. En la actualidad, la educación debe preparar a los jóvenes para el diálogo cultural, por lo tanto los objetivos del estudio fueron socializar la importancia de la educación intercultural en la enseñanza de idiomas extranjeros, identificar las diferencias y similitudes en la cultura que influyen en el proceso de adaptación en un país distinto y determinar los signos y síntomas del choque cultural experimentados por los estudiantes internacionales en países extranjeros. En esta investigación sociolingüística se utilizaron entrevistas y cuestionarios con preguntas cerradas y abiertas. Al ser una investigación mayormente cualitativa, las opiniones, vivencias y consejos de los participantes registrados de manera escrita permitieron agrupar los resultados en tres aspectos generales a considerar por los docentes que enseñan idiomas extranjeros: la imagen del mundo interior (mental y emocional), los estereotipos y el choque cultural. Como conclusión se obtuvo que los participantes desconocían los conceptos de interculturalidad; las variaciones en la imagen del mundo interior fueron significativas de una cultura a la otra, los estereotipos afectaron negativamente la comunicación intercultural y que el desconocimiento de la cultura influyó en el choque cultural.