bluuebunny/crossref_metadata_2025 huggingface dataset:
Hubungan Ekspresi Tumor Infiltrating Lymphocytes dengan Klinikopatologi pada Subtipe Luminal A dan Triple Negative Kanker Payudara di Bali
Authors: Widiana I Gede Tuban Eling Tulus , Suryawisesa Ida Bagus Made , Widiana I Ketut
Published: July 2020

Tujuan: Untuk membuktikan adanya hubungan ekspresi TIL dengan klinikopatologi pada subtipe luminal A dan subtipe TNBC beserta ada tidaknya perbedaan antara kedua subjek tersebut. Metode: Penelitian ini merupakan penelitian observasional, dirancang secara potong-lintang di RSUP Sanglah Denpasar. Kriteria inklusi adalah penderita kanker payudara subtipe luminal A dan subtipe TNBC (triple negative breast cancer) sebagai subjek penelitian. Hasil: Pada penelitian ini terdapat 31 subjek dengan Luminal A dan 40 subyek dengan TNBC. Penelitian ini didapatkan hubungan signifikan antara stadium dengan kadar TIL pada kanker payudara subtipe TNBC (p=0,01). Pada kanker payudara subtipe TNBC stadium tinggi, kemungkinan TIL tinggi 3 kali dibandingkan dengan subjek dengan stadium I-II. Adanya hubungan yang bermakna pada penderita dengan TIL tinggi dengan stadium lanjut pada subtype TNBC dan luminal A (p=0,028; PR 1,8; 95%CI 0,54-5,9). Simpulan: Tidak terdapat hubungan signifikan yang diperoleh antara TIL dengan ukuran tumor, stadium klinis, grade histopatologi pada kanker payudara subtipe luminal A maupun TNBC. Tidak terdapat pula hubungan ukuran tumor dan grading tumor antara kanker payudara dengan subtipe TNBC dan luminal A yang memiliki TIL yang tinggi, tetapi terdapat perbedaan pada stadium tumor.
ASPEK ERGONOMI DARI RISIKO PSIKOSOSIAL DI TEMPAT KERJA
Authors: Sutjana IDP
Published: July 2020

Perkembangan ilmu pengetahuan dan teknologi (IPTEK) sangat pesat beberapa dekade terakhir ini telah terbukti memberikan manfaat yang sangat besar bagi kesejahteraan masyarakat, namun tanpa disadari juga menimbulkan dampak negatif seperti meningkatnya keluhan, penyakit akibat kerja, kecelakaan kerja, maupun stres. Disamping itu di era global para pekerja menghadapi 3 C (complexity, competition, changes), sehingga dituntut selalu harus mengikuti perkembangan IPTEK, kalau tidak akan ditinggal dan pasti akan selalu  ketinggalan.  Pada kondisi demikian itu bagi  yang kurang mampu mengikuti perkembangan akan mengalami kegelisahan yang diikuti dengan stres sebagai salah satu risiko psikososial dengan segala akibatnya. Oleh karena masalah yang dihadapi makin kompleks dengan persaingan yang makin ketat maka gejala gangguan psikososial itupun makin meningkat. Gangguan psikososial akan menimbulkan berbagai keluhan yang diikuti penurunan produktivitas kerja, bahkan bisa menimbulkan kecelakaan kerja. Ergonomi sebagai pendekatan multi/interdisiplin, dimana disiplin psikologi merupakan bagian dari pendekatan ergonomi juga membahas risiko psikososial yang dihadapi pekerja. Ergonomi berupaya menciptakan kondisi kerja yang sehat, aman, nyaman, efektif dan efisien atau serasi dengan pekerja untuk meningkatkan produktivitas dan kesejahteraan pekerja. Dalam hal ini diupayakan adanya keserasian antara task, organisasi dan lingkungan kerja terhadap kemampuan, kebolehan dan batasan manusia, sehingga seseorang mampu bekerja dengan maksimal, dengan risiko yang minimal, termasuk risiko psychosocial. Jadi semua aspek ergonomi tersebut juga merupakan faktor yang bisa menimbulkan risiko psycholsosial. Komponen dari task seperti jenis pekerjaan, beban kerja, tanggung jawab merupakan aspek ergonomi, juga sebagai faktor yang dapat menimbulkan risiko psikososial. Organisasi seperti pengaturan giliran kerja, jam kerja dan jam istirahat, hubungan antara pekerja atau dengan atasan atau bawahan, sistem penggajian, penghargaan dan sangsi, demikian jugafaktor lingkungan kerja seperti faktor sosial, perbedaan ras, etnis, budaya, agama adalah aspek ergonomi yang merupakan faktor yang dapat menimbulkan risiko psychsosial. Apabila ditinjau dari pendekatan ergonomi total dimana dibahas hubungan pekerja dengan task, organisasi dan lingkungan kerja maka aspek ergonomi hampir sama dengan faktor risiko psikososial
PERBEDAAN SKOR WORK ENGAGEMENT PADA GURU YANG BERSERTIFIKASI DENGAN GURU YANG BELUM BERSERTIFIKASI DI SMP NEGERI SE-KECAMATAN DENPASAR UTARA
Authors: Aditya Gede Andi , Adiputra I Nyoman
Published: July 2020

Optimum performance is achieved when teacher has been engaged with his or her work. Teacher will not feel forced to run his or her job demand and even tend to give more than his or her job demand. These are ideal condition that must be maintained in teacher profession. Efforts to do so teacher engaged with his or her work is to provide an acknowledgment and appreciation.  It can be seen from one of the government's regulations implementing teacher certification.  Observational studies have been conducted with a cross-sectional analytical approach to the teacher at SMP Negeri inNorth District of Denpasar with a sample of 147 peoples. Data were analyzed with the Mann-Whitney test with a significance level of 0.05. Research data obtained an average scores of work engagement on the certified teachers is 86.23 + 8,31 while the average scores of work engagement on uncertified teachers is 79.25 + 11,93. Comparability of test results p = 0.003, showing that the average scores of work engagement among certified teachers and uncertified teachers significantly different (p <0.05). It can be said certification is one of the variables that affect the work engagement on teacher. It was concluded that there are differences in the average scores of work engagement oncertified teacher with uncertified teacher, where work engagement scores on certified teacher is higher than uncertified teacher. It is recommended for government to certify all teachers in Indonesia.
HUBUNGAN KELELAHAN DENGAN KEMAMPUAN KERJA KARYAWAN BAGIAN HOUSEKEEPING HOTEL BINTANG TIGA DI DENPASAR
Authors: Suastini Ni Kadek , Adiputra I Nyoman
Published: July 2020

Tourism has become one of the engines of socio-economic progress for many countries. The number of  users  star hotel facilities  makes  the hotel more  extra  employees  in negotiating the arrangement of the hotel especially the housekeeping employees who workwith emphasis on physical strength as the center of activities that affect the fatigue and employability.  This study analyzed  the correlation between  fatigue  and work ability. Research  conducted  observational  (non-experimental) with a  cross-sectional  analytic 59approach. The number of respondents consisted of 31 respondents consisting of employees of the housekeeping three stars hotel in Denpasar, to fill in the questionnaire Work AbilityIndex and the 30 item questionnaire rating scale of the Japan Association of IndustrialHealth and Industrial Fatigue Research Committee of Japan. From the research, there is40.81 ± 9.35 mean of fatigue. While, the average of work ability is 41.25 ± 4.15. There is asignificant relationship between the fatigue and the work ability with the value of (p =0.011) and values of (r = -0,450). The p-value indicates there is a significant relationshipbetween fatigue and work ability, the value of r indicates the direction opposite relationshipbetween fatigue and work ability. It can be concluded that there is a relationship betweenfatigue with the work ability of employees at the hotel housekeeping. For the hotel need to know the fatigue scores of each individual to improve the employees work especially those working in the field of physical and mental.
PERBAIKAN INTENSITAS CAHAYA MEMPERCEPAT WAKTU REAKSI PADA SISWA KELAS ENAM SEKOLAH DASAR NOMOR 8 DAUH PURI DENPASAR
Authors: Bhargah Agha , Muliarta Made
Published: July 2020

The learning process in a room with low intensity may cause the eyestrain amongstudents, it would be a disadvantage because it makes students become tired and sleepy. The assessment of fatigue used psychomotor reaction time test. This test provides a description of the fatigue that occurs among students. This study aims to investigate the influence of improvement of light intensity to the reaction time among sixth grade students at ElementarySchool Dauh Puri Number 8 Denpasar.This research was using pre experimental study with the one group pre test-post test design among sixth grade students at Elementary School Dauh Puri Number 8 Denpasar. This study used 22 subjects, 11 men and 11 women. The study was conducted first by measuring the reaction time after the first period of study is completed, and then the light intensity improved to meet the standards for one week. The second measurement of the reaction timedid after one week period of the intervention.The results showed a significant difference between the reaction time before the intervention (522 ms) and after the intervention (476 ms), CI 95% : 42.68 – 50.68, p = 0.000. There was additional data regarding the reaction time comparisons between men and women. The reaction time is faster in men (480 ms) than in women (564 ms), p = 0.004. It was concluded that the improvement of light intensity is able to accelerate the reaction time, and reaction time is faster in men than women.
PREVALENSI KELUHAN MUSKULOSKELETAL DAN KELUHAN KESEHATAN LAINNYA PADA PEKERJA PURA BATU PADAS DI DESA TAMBLANG DALAM KONSEP HEALTH ERGONOMIC
Authors: Sukedana Putu , Adiputra Luh Made Indah Sri Handari
Published: July 2020

Bali is known as the island of a thousand temples. Temple builders had to cut hard rock and assemble them. Musculoskeletal complaints often experienced among the workers. The purpose of the study was to find out the prevalence of musculoskeletal complaints on the temple builders at Tamblang Village.This research was using a cross-sectional study and the results were analyzed descriptively. Respondents were 32 temple builders as assemblers and stonecutter at Tamblang Village. Respondents were requested to filled Nordic Body Map questionnaire. The result showed that musculoskeletal complaints on assemblers are on the waist 75%, right and left elbow joints 45.8%, right and left shoulder 41.7%, and wrist 37.5%. Musculoskeletal complaints on locomotor are on knee 29.2%, calf 12.5% and ankle 25%. Musculoskeletal complaints on stonecutter are on the waist, arm, shoulder, neck, elbow, and back. Musculoskeletal complaints on locomotor are on knee 62.5%, calf 62.5%, and ankle 50%. Most of respondents complaint about elbow, wrist, waist, knee, and ankle.Other complaint on temple builders is on the respiratory system, nervous system, and others.15.6% of assemblers said tightness, and 6.25% of stonecutter. The nose complaint on assemblers is 3.1%. The numbness complaint on stone cutter is 6.25%. Other complaint is on the eye and chest, experienced only on assemblers as much as 6.25% of respondents
HUBUNGAN BEBAN OTOT TANGAN AKTIVITAS PENGETIKAN NASKAH BALI DENGAN KEYBOARD QWERTY TERHADAP HASIL BELAJAR
Authors: Suhartana I KG , . N Adiputra , . K Tirtayasa , Sutjana I Dewa Putu
Published: July 2020

As a human tools, computer is used in various sectors of human life, for examples: writing documents, playing  multimedia  and so on.  Making document withBalinese charactersusing a computer has many obstacles such as letters, points, and sign in Balinese charactershave different forms with letters, points, and sign in alphabetic. Another difficulty is the keyboard that is commonly used is not specific to type Balinese script. This research was aimed to determine the correlation between a decrease of  hand muscles load activity typing Balinese scripts with QWERTY keyboard on the increase in learning outcomes. This research was done by using descriptive correlation. Samplesof this research were 23 students who meet the inclusion and exclusion criteria were selectedrandomly. The correlation test results showed that there is a strong correlation between a decrease hand muscle load with the learning outcomes of r xy = -0.963 and p = 0.001. This shows that there is a significant correlation between a decrease hand muscle load with increase learning outcomes with p <0.05. There is a strong correlation and significant between a decrease hand muscle load with increase learning outcomes on Balinese typing activity usingQWERTYkeyboard
The Economic Efficiency of Buffalo Business (Bubalus Bubalis) With the Shepherd
Authors: Rusdiana Supardi , Praharani Lisa , Sianturi Riasari Gail
Published: July 2020

Buffalo has a very big role to the family economy of stockbreeders. But until now, buffalo business in Banten Province is still small, and has not led to commercial business. The research was conducted in Cibarani Village, Cisata District, Pandeglang Regency, Banten in 2016. This study used interview and questionnaire filling methods to the 24 buffalo breeders. By accidental sampling, sampling of respondents was found in the cage, house, paddy field and fields. Primary data were obtained from stockbreeders and secondary data were obtained from the local institution. Primary and secondary data were analyzed descriptively, quantitatively, t-test analysis and economic analysis. The aim of this research was to determine the economic efficiency of buffalo business (bubalus bubalis) with the shepherds in stockbreeders. The results showed that, the factors that influenced the increased economic efficiency of buffalo business in breeders had a significant effect on (P <0.05) to the breeders profits variable. The female buffalo business by breeding, breeders' profits was Rp.7.889.000 / year, with R / C 1.02 higher. The male buffalo business by fattened up, breeders’ profits amounting to Rp.7.575.000 with R / C of 1.05 lower. The buffalo business in breeders by shepherded, through male fattened up or breeding, was economically worth to try.
The Development Strategy of ‘Cinta Mangrove Park’ Ecotourism In Mempawah Regency
Authors: Kurniati Dewi , Dolorosa Eva
Published: July 2020

Mempawah Regency is an area located on the coast that has a wide area of mangrove forest. The mangrove forest is used to prevent abrasion and as an ecotourism area. This regency has three mangrove ecotourism; they are Mempawah Mangrove Park, Polaria Tanjung Pagar Mangrove Park and Cinta Mangrove Park. Cinta Mangrove Park is the newest mangrove ecotourism in Mempawah Regency. As the latest ecotourism, there are still some shortages, upgrading and developments that need to be done in terms of human resources, facilities and less of promotion. The aim of this research was to determine the development strategy of the Cinta Mangrove Park ecotourism. The location of the research was carried out at the Cinta Mangrove Park Ecotourism in Sungai Bakau Besar Laut Village Sungai Pinyuh Sub-District Mempawah Regency with the consideration that this location was the latest ecotourism that still has a lot of shortages and need improvement.  The selected respondents were the key informants. The analysis used was SWOT and QSPM analysis. The results of the research described that the mangrove ecotourism development strategy was a weakness-opportunity (WO) strategy. The main priority of the Cinta Mangrove Park ecotourism development strategy was to seek funding sources and attract investors to collaborate to build tourism facilities. The results of this research were expected to be a contribution in determining policies for the government and society for the development of the Cinta Mangrove Park ecotourism.
The KoBoCollect for Research Data Collection and Management (An experience in Researching the Socio-Economic Impact of Blood Disease in Banana)
Authors: Nampa I Wayan , Mudita I Wayan , Riwu Kaho Norman Patrick Lucky Bire , Widinugraheni Sri , Lasarus Natonis Remi
Published: July 2020

In the research field, smartphone began to be used for field data collection. One application that was used was KoBoCollect. This article shared the experience of using KoBoCollect in research on the socio-economic impact of blood diseases on banana in Sumba Island. The research was conducted by interviewing 64 banana farmers that spread proportionally in four regencies in Sumba Island. The use of KoBoCollect/toolbox made it easy to collect, save and manage research data. KoBoCollect/toolbox provided the advantages of conducting paperless research, able to record data in complex formats such as numeric data, descriptive data, photos, videos, sounds, coordinates and other data, dynamically making forms changes when conducting research, and displaying interactive applications. KoBoCollect can be run off-line, made it possible to collect field data in remote locations and no internet network. The research data was transmitted online so that the data tabulation process was automatic. Simple data analysis such as median values, mode, graphs and distribution maps of data collection were provided in KoBotoolbox. With KoBoCollect/toolbox, researchers quickly find out the results of the research, as in this research it was known that blood disease had an impact on the decrease in the banana population revealed by 81.54% of farmers.
The Fulfillment of Hierarchy of Needs of Elinor in The "Sense And Sensibility" Novel by Jane Austen: A Study of Humanism Psychology of Abraham Maslow
Authors: Ghozali Imam
Published: July 2020

This research was intended to find and describe the fulfillment of hierarchy of needs of Elinor in the “Sense and Sensibility” by Jane Austen which mostly about the story of Dashwood family, Elinor and Marianne Dashwood. The story began with their father’s death, Henry Dashwood. He left only a small fortune to Elinor, Marianne, their mother and younger sister, while most of Dashwood's wealth and property were handed over to John, Henry's son from his previous marriage. Elinor's struggles to fulfill her needs began with discomfort that occurred in her family. The method used was a qualitative descriptive, in which the data were in the form of words, sentences, and paragraphs that identified the fulfillment of hierarchy of needs. The data source was the "Sense and Sensibility" novel by Jane Austen and the data collection techniques were reading and note-taking. The data were analyzed by identifying, classifying, describing and drawing conclusions. The results and discussion in this article showed that in fulfilling her physiological, safety, love and belonging, and esteem needs, Elinor faced struggles and twist and turn. Those four needs were found sequentially in the story, but the need for self-actualization had not been reflected in the novel.
The US-Turkey Relations Endure Despite Crises
Authors: Ustun Kadir
Published: July 2020

The U.S.-Turkey relationship has been tested through some of the most serious crises in recent years. The continuing strength of the relationship, despite all the tensions which have resulted from some difficult strategic disagreements and diverging interests, requires a closer look. The two NATO allies appear to have learned to ‘agree to disagree’ and compartmentalize some of the seemingly most deal breaking issues. As Turkey sought to protect its national interests, some in Washington have tried to depict Turkey as a bad actor working against U.S. interests in the region and beyond. The recurring theme of Turkey, somehow leaving the West and aligning itself with the East, has convinced many in the U.S. that Turkey cannot not be trusted. However, the U.S.-Turkey relationship has survived despite years of mutual mistrust, strategic divergences, and policy differences. Explaining how this has been possible is not simple by any means, but it is worth exploring.
The Post-COVID-19 Economic Recovery: U.S.-Turkey Commercial Ties that Bind
Authors: Miel Jennifer
Published: July 2020

This paper examines the commercial opportunities that will endure in key sectors for the United States and Turkey in the midst of the coronavirus pandemic and its aftermath. These sectors include financial services and capital markets; supply chains and logistics; healthcare; digital economy; defense and aerospace; energy; travel and tourism; and women in business. While defense and security ties have traditionally led the U.S.-Turkey relationship, this piece argues that the pandemic offers the two countries mutual benefits from more robust economic and commercial cooperation in less prominent sectors such as healthcare, the digital economy, and finance.
Social Media and Fake News in the Post-Truth Era: The Manipulation of Politics in the Election Process
Authors: Yerlikaya Turgay , Toker Seca
Published: July 2020

This article focuses on how virtual social networks affect socio-political life. The main theme of the article is how social networks such as Facebook and Twitter can direct voters’ electoral preferences, especially during election time, through the dissemination of manipulative content and fake news. The use of social media, which was initially thought to have a positive effect on democratization, has been extensively discussed in recent years as threat to democracy. Examples from the 2016 U.S. presidential elections, France, Brexit, Germany, the UK and Turkey will be used to illustrate the risks that social networks pose to democracy, especially during election periods.
Clinical and Immunological Response to Doxycycline Versus Doxycycline Plus Vitamin C in Patients with Acne Vulgaris
Authors: Al Mukhtar Entisar J. , Shubber Zahraa I. J. , Al-Shibly Ifad K.
Published: July 2020

Objective: Study the influence of doxycycline versus doxycycline with vitamin C drugs in the management of acne vulgaris on some immunological parameters which include [Interleukin 1 beta (IL-1β), interleukin 1 (IL-8), interferon gamma (IFN-γ), tumor necrosis factor alpha (TNF-α), and toll-like receptor 2 (TLR2)] and the following objectives were adapted: 1-Selection of population for the study (control, patients) groups and follow up the patients after one month of treatment, the first group receive doxycycline and the second group receive doxycycline with vitamin C,2- Blood samples collection and separation of serums for immunological analysis, 3- Statistical analysis.
Methods: This study is a randomized clinical trial carried out in clinical dermatology in Merjan Medical city in Babylon from September 2018 to March 2019. The number of subjects enrolled in the present study was 60; their age was between (14–30 years), among whom 30 were acne patients, the remaining 30 subjects were apparently healthy individuals, and they were served as control. A dermatologist diagnosed a total of 30 acne patients to having moderate to severe acne and divided into two groups (15 patients in each group). Patients in the first group were treated with doxycycline (100mg) once daily after meal for 30 days, while in the second group patients were treated with doxycycline (100mg) capsule once daily after a meal in combination with vitamin C (500mg) chewable tablets once daily. After 1-month of therapy, the response was evaluated clinically and immunologically by measure the concentration of pro-inflammatory cytokines (IL-8, IL-1β, IFN-γ, TNF-α) and (TLR-2 ) by using enzyme-linked immunosorbent assay (ELISA) and the results were compared to their levels before treatment and that in the control group.
Results: Significant elevation in the serum levels (p less than or equal to 0.001) of immunological parameter IL-8, IL-1β, IFN-γ, TNF-α, and TLR-2 among acne patients in comparison to the control. The clinical response in the first group was good, moderate and poor in 5 (33%), 7(47%) and 3(20%) respectively, while in the second group was good, moderate and poor in 7 (47%), 7(47%) and 1(6%) respectively, the immunological results showed that the serum levels to the (IL-1β, IL-8, IFN-γ, TNF-α) and (TLR-2) were more reduced in the second group compared to their levels in the first group.
Conclusion: Significant elevation (p less than 0.001) in the serum levels of (IL-8, IL-1β, IFN-γ, TNF-α, and TLR-2) among moderate to severe acne patients in comparison to control group. Clinically the combination of doxycycline plus vitamin C was more efficient as therapeutically in comparison to doxycycline alone. Immunologically doxycycline plus vitamin C was more effective in reducing serum levels of (IL-8, IL-1β, IFN-γ, TNF-α, and TLR-2) in comparison to doxycycline alone.
The Therapeutic Efficacy of Microneedling Combined with Topical Tacrolimus vs. Microneedling Alone in Treatment of Stable Vitiligo. A Comparative Study.
Authors: Dahash Muqdad A. , Ahmed Ahmed A. , Fateh Dalya M. , Najim Wisam S.
Published: July 2020

Background: Vitiligo is an acquired depigmentary disorder of multifactorial etiology. Several treatment modalities have been attempted with partial success, but the recent focus on surgical treatment like micro-needling.
Objective: To compare the safety and ability of micro-needling alone in the induction of pigmentation in stable vitiligo versus combined tacrolimus treatment and micro-needling.
Patients and methods: Twenty three patients with stable vitiligo were recruited from the Department of Dermatology and Venereology of Salah Aldeen General Hospital. The patients then subjected to micro-needling of the two vitiliginous patches after that application of topical tacrolimus to the left patch. This procedure was repeated every two weeks for a maximum of 5 months ( 10 sessions).
Results: Microneedling with topical tacrolimus showed better but non-significant response than micro-needling alone ( p = 0.519). Moderate improvement occurred in 13% of patches treated with micro-needling alone, while only 9% show moderate improvement in combined treatment. Although 9% show good improvement in combined treatment.
Conclusion: Micro-needling induces pigmentation in vitiligo patients, and the addition of topical tacrolimus induces a better response.However, no statistically significant response was observed in any group.
Modulation of GILZ and Erg upon Non-Steroidal Treatment
in Chicken Leukemic Cells
Authors: Al-ibad Israa N A , Atyia Hiba T , Khudeir Mahasen A A , Alrammahi Miran A A A , Mutter Hala M , Neamah Ahmed J
Published: July 2020

Background and aims: Glucocorticoids (GCs) have been successfully employed in the treatment of human leukemia; however, those effects can be deteriorated as the metabolic side effects occurred due to the activation glucocorticoid-induced leucine zipper (GILZ) leading to the induction of the GC resistance which is initiated via the Ets-related gene (Erg). In the present work, we recruited this antagonist influence on ERG for aiming to understand the physiological potential that might be of benefit in the treatment of leukemia using a non-steroidal compound (CPDA).
Methods: We examined the effect of dexamethasone, as a steroid, and CPDA, as a non-steroid substance, on the GILZ and ERG receptor gene expression in The chicken leukemia cells (CLCs), DT40 cells, after treating them with the drug at 1μM followed by a 24-hour incubation. A real-time-polymerase chain reaction (RT-PCR) method was used to measure gene expression.
Results: An increase (two-fold) in the expression of GILZ receptor was unveiled. This enhanced-GILZ model presents the steroidal positive actions and refers to the CPDA ability to mimic this action of steroids. The results also demonstrated a downregulation in the mRNA expression level of ERG, indicating of antagonism of steroids in responding cells and as a positive finding for the effect of the non-steroidal compound A tested.
Conclusions: Steroid-induced upregulation in the GILZ receptor provides proof of GC undesirable effects leading to correlated ERG-initiated resistance to the steroids used in exposed cells. Interestingly, CPDA has a GC-based treating activity low GILZ expression.
Simulated Role-Playing in Pharmacy
Authors: Alshammari Elham
Published: July 2020

Role-play refers to a situation that allows learners to examine realistic situations by interacting with other individuals in a controlled way to develop experience and try different strategies within a supported environment. Depending on the objective of the activity, learners may play a role that is related to their own or could take on an opposite part as well. In this study, the author sought to investigate the satisfaction and perception of pharmacy students toward role-playing. The study used a prospective study design and collected data from students at Princes Nourah bint Abdulrahman University (PNU). The researcher used a rubric that allowed the learners to select their responses as either “Poor,” “Average,” “Proficient,” or “Excellent.” The rubric was distributed to 6th level pharmacy students who experienced role-play for the first time in a classroom session. The findings showed that role play helped in the development of professional skills, recognized possible arguments and solutions, facilitated better understanding, developed the confidence of the learners, enhanced their communication skills, promoted effective discussion, and encouraged active participation. These observations were discussed in light of past studies that have focused on the domain of role-playing. Based on these findings, the study recommends the use of simulation and role-play in teaching pharmacy programs.
Mutfak Çalışanlarında Algılanan Dışsal Prestij ve İşe Adanmışlığının Yenilik Performansına Etkisi: Nevşehir İlinde Bir Uygulama
Authors: BALKI Selcen , İLHAN İbrahim , ÖZKOÇ Aziz
Published: July 2020

Bu çalışmanın amacı,
Nevşehir ilinde faaliyet gösteren konaklama işletmelerinde mutfak personelinin
algılanan dışsal prestij ve işe adanmışlığa yönelik eğilimlerini ölçerek
yenilik performansına etkisini belirlemektir. Bu amaçla, algılanan dışsal
prestij, işe adanmışlık ve yenilik performansı arasındaki etkileşimin teorik
arka planı irdelenerek yapısal bir model önerilmiş ve bu model uygun
istatistiksel analizler ile test edilmiştir.  Çalışma kapsamına Nevşehir ilinde faaliyet
gösteren konaklama işletmelerinde görev yapan mutfak çalışanları dahil edilmiştir.
Veriler anket tekniği ile toplanmıştır. Araştırma sonucunda algılanan dışsal
prestij ile işe adanmışlık arasında pozitif yönlü anlamlı bir etkileşimin
olduğu ve ayrıca bu iki bağımsız değişkenin yenilik performansını olumlu yönde
etkilediği sonucuna ulaşılmıştır.
Bilgi Yoğun Hizmetler Alt Sektörlerinde Öğrenme Eğrileri
Authors: ÇALMAŞUR Gürkan , DAŞTAN Hüseyin , KARACA Zeynep
Published: July 2020

Öğrenme eğrisi, firmanın kümülatif toplam üretimi arttıkça ortalama maliyetlerindeki düşüşü göstermektedir. Tek değişkenli ve çok değişkenli olmak üzere farklı öğrenme eğrisi modelleri vardır. Geleneksel tek değişkenli öğrenme eğrisi, üretim maliyeti gibi bir bağımlı değişkeni kümülatif üretim miktarı vb. Bağımsız değişkenler açısından açıklamaya çalışmaktadır. Tek değişkenli modeller arasında Log-Lineer model, S-eğrisi, Stanford-B modeli, DeJong'un öğrenme formülü, Levy'nin adaptasyon fonksiyonu, Glover'ın öğrenme formülü, Pegel'in üstel fonksiyonu, Knecht'in yükselme modeli, Yelle'nin ürün modeli sayılabilir. Söz konusu modeller içinde S-eğrisi veya kübik öğrenme modeli, öğrenme seviyesinin zaman içinde değiştiğini varsaymaktadır. Öğrenme eğrileri geleneksel olarak sanayi ve hizmet sektörlerinde kullanılmaktadır. Hizmetler sektörü, nihai ürünlerden ziyade hizmetin üretildiği bir endüstri koludur. Bu çalışmanın ana amacı, 2003-2017 dönemi için Türk Bilgi Yoğun Hizmetler alt sektörlerine ait öğrenme eğrilerini detaylı bir biçimde analiz etmektir. Bu amacı gerçekleştirmek için kübik öğrenme modeli, 2003 ve 2017 yılları arasında Bilgi Yoğun Hizmetler alt sektörleri için öğrenme (ilerleme) oranı değerleri tahmin edilmiş ve hesaplanmıştır. Çalışmadan elde edilen bulgulara göre, Bilgi Yoğun Hizmetler sektörlerinde her bir alt sektördeki öğrenme eğrisinin dış bükey, içbükey, negatif ve pozitif eğimli olmak üzere dört farklı şekle sahip olduğu görülmüştür.
Kamu Hizmeti Anlayışındaki Değişimin Türk Yönetim Geleneği Çerçevesinde Değerlendirilmesi
Authors: ARSLAN Şadiye
Published: July 2020

Yirminci yüzyılın son çeyreğinde kamu hizmeti sunumunda meydana gelen değişimler birçok araştırmanın konusu olmuştur. Daha önce geçerli olan yönetim araçlarının kökten değişimine yol açan bu süreç, çok geçmeden tüm dünyayı etkisi altına almayı başarmıştır. Artık kamu hizmeti anlayışı da iki farklı perspektifte yorumlanmaktadır. Bunlardan ilki klasik bağlamda devlet iktidarı veya kamu yararı adına hareket etmeye dayalı kamu hizmeti anlayışı, diğeri bir işletme tekniği olarak kamu hizmeti anlayışıdır. Bu çalışmanın amacı kamu hizmeti anlayışında yaşanan değişimin genel aşamalarına değinerek Türkiye’deki yönetim geleneği çerçevesinde incelenmesidir. Kamu hizmeti anlayışında yaşanan değişimi teorik zeminde ele alan çalışma, konuya ilişkin literatür taranarak değerlendirilmiştir. Bu kapsamda kamu hizmeti anlayışındaki değişim Robert B. Denhardt ve Janet V. Denhardt’ın üç aşamada ele aldığı gibi Klasik Kamu Yönetimi, Yeni Kamu İşletmeciliği ve Yeni Kamu Hizmeti yaklaşımlarından yola çıkılarak incelenmiştir. Çalışmada söz konusu yaklaşımların Türk kamu hizmeti anlayışındaki değişimine olan katkısı yerleşik yönetim geleneği ve kültürü çerçevesinde ele alınmıştır.
Target-Templated de novo Design of Macrocyclic D-/L-Peptides: Inhibitors of the PD-1/PD-L1 Interaction
Authors: Guardiola Salvador , Varese Monica , Roig Xavier , Garcia Jesús , Giralt Ernest
Published: July 2020

NOTE: This preprint has been retracted by consensus from all authors. See the retraction notice in place above; the original text can be found under "Version 1", accessible from the version selector above.

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Peptides, together with antibodies, are among the most potent biochemical tools to modulate challenging protein-protein interactions. However, current structure-based methods are largely limited to natural peptides and are not suitable for designing target-specific binders with improved pharmaceutical properties, such as macrocyclic peptides. Here we report a general framework that leverages the computational power of Rosetta for large-scale backbone sampling and energy scoring, followed by side-chain composition, to design heterochiral cyclic peptides that bind to a protein surface of interest. To showcase the applicability of our approach, we identified two peptides (PD-i3 and PD-i6) that target PD-1, a key immune checkpoint, and work as protein ligand decoys. A comprehensive biophysical evaluation confirmed their binding mechanism to PD-1 and their inhibitory effect on the PD-1/PD-L1 interaction. Finally, elucidation of their solution structures by NMR served as validation of our de novo design approach. We anticipate that our results will provide a general framework for designing target-specific drug-like peptides.
Semisynthetic Analogs of the Antibiotic Fidaxomicin – Design, Synthesis, and Biological Evaluation
Authors: Dorst Andrea , Berg Regina , Gertzen Christoph , Schäfle Daniel , zerbe katja , gwerder myriam , Schnell Simon , Sander Peter , Gohlke Holger , Gademann Karl
Published: July 2020

The glycoslated macrocyclic antibiotic fidaxomicin (1, tiacumicin B, lipiarmycin A3) displays good to excellent activity against Gram-positive bacteria and was approved for the treatment of Clostridium difficile infections (CDI). Main limitations of the compound include low water solubility, which impacts further clinical use. We report on the synthesis of new fidaxomicin derivatives based on structural design and utilizing an operationally simple one-step protecting group-free preparative approach from the natural product. An increase in solubility of up to 25-fold with largely retained activity was observed. Furthermore, hybrid antibiotics were prepared that show improved antibiotic activities
A Novel Enzyme-Triggered Domino Reaction Producing Fluorescent Quinoxalin-2(1H)-One-Based Heterocycles
Authors: Dejouy Garance , Renault Kevin , Bonnin Quentin , Chevalier Arnaud , Michaudet Cédric , Picquet Michel , Valverde Ibai E. , ROMIEU Anthony
Published: July 2020

A simple and effective biocompatible domino reaction triggered by a model protease and leading to formation of strongly fluorescent quinoxalin-2(1H)-one N-heterocycles is described. Some positive attributes including versatility and ability to provide outstanding fluorescence "OFF-ON" responses were revealed by this work. They open the way for practical applications of this novel type of "covalent-assembly" based fluorescent probes in the fields of sensing and bioimaging.
The effectiveness of endovascular revascularization of the carotid basin performed before coronary artery bypass grafting in patients with combined atherosclerotic lesions of cerebral and coronary arteries
Authors: Grigoruk S.P.
Published: July 2020

Objective – to determine the effectiveness of endovascular revascularization of the carotid pool (carotid stenting) in patients with combined atherosclerotic lesions of the cerebral and coronary arteries, which showed coronary artery bypass grafting (CABG). Materials and methods. 40 patients with combined atherosclerotic lesions of the cerebral and coronary arteries were included in the study. All patients for 14 days before CABG were stented carotid artery. The number of complications and the treatments results were determined. Survival functions were determined to evaluate long-term treatment outcomes over a 10-year follow-up period. Results. 32.5 % of patients had complications after carotid pool revascularization: angina pectoris – 12.5 %, acute myocardial infarction – 2.5 %, transient ischemic attack – 12.5 %, ischemic stroke – 2.5 %, arterial hypotension – 2.5 %. 98.2 % of patients observed positive results of treatment for neurological status. After revascularization of the coronary pool, 45 % of patients had complications: angina – 27.5 %, cardiac arrhythmia – 27.5 %, acute myocardial infarction – 2.5 %, transient ischemic attack – 7.5 %, ischemic stroke – 7.5 %. 83.5 % of patients received positive results of treatment. The 10-year survival rate after surgery was 19 % [34 %; 7 %]. Decrease in survival function was observed uniformly throughout the observation period: 3-year survival – 83 % [92 %; 67 %], 5-year survival – 56 % [70 %; 39 %].Conclusions. Positive results of treatment in patients with combined atherosclerotic lesions of the cerebral and coronary arteries, which performed stenting of the carotid arteries before CABG, are observed in 98.5 % of patients. Carotid artery stenting before CABG is an effective method of preventing cerebral complications in the early postoperative and distant periods. Long-term results of treatment are accompanied by low rates of 5-year and 10-year survival after revascularization of the carotid and coronary pools.
AM MODE: Using AM and FM Synthesis for Acoustic Drum Augmentation
Authors: Champion Cory , Zareei Mohammad
Published: July 2020

No description supplied
Green Prescriptions And Therapeutic Landscapes: A New Zealand Study
Authors: Marques Bruno , McIntosh Jacqueline , Popoola Tosin
Published: July 2020

No description supplied
Extended reality for chronic pain relief
Authors: Wang J , Anslow Craig , Robinson Brian , McCallum Simon
Published: July 2020

© 2019 Copyright held by the owner/author(s). Chronic pain is ongoing pain lasting for long periods of time after the initial injury or disease has healed. Chronic pain is difficult to treat and can affect the daily lives of patients. Distraction therapy is a proven way of relieving pain by redirecting the focus of patients' attention. Virtual reality is an effective platform for distraction therapy as it immerses the user visually, aurally, and even somewhat physically in a virtual world detached from reality. There is little research done on the effects that physical interactions have on pain management. This project aims to evaluate different types of extended reality (XR) interactions, including full body movement, for chronic pain patients to determine which is the best for pain relief. We are building a prototype for participants to interact both mentally and physically and measuring the reduction in subjective pain ratings at various points of the XR experience.
Design patterns for Angular Hotdraw
Authors: Escott KR , Noble Robert
Published: July 2020

© 2019 Association for Computing Machinery. The number of web frameworks available for use is growing. Web developers need to learn how to use them effectively and efficiently. Working through the design patterns presented in this paper for the Angular Hotdraw application assists web developers in this task. Web developers should be able to make a start with a the Angular web framework and have a foundation to learn from.
Te Rangatiratanga o te Reo: Sovereignty in Indigenous Languages
Authors: Ritchie Jenny , Skerrett Mere
Published: July 2020

No description supplied
Restorative Justice and Children's Rights in Aotearoa New Zealand - Convergence and Divergence
Authors: Lynch Nessa , Păroşanu Andrea
Published: July 2020

No description supplied
Generating Knowledge-Guided Discriminative Features Using Genetic Programming for Melanoma Detection
Authors: Ain Qurrat Ul , Al-Sahaf Harith , Xue Bing , Zhang Mengjie
Published: July 2020

No description supplied
Technological enablers for preventing service failure with e-commerce websites
Authors: Nili A , Barros A , Johnstone David , Tate M
Published: July 2020

© 27th European Conference on Information Systems - Information Systems for a Sharing Society, ECIS 2019. All rights reserved. Problems with digital services still occur at times, even for the most reliable services. Considering the consequences of these failures and their effects on the customer's overall service quality perception and satisfaction, preventing these failures, and delivering reliable digital services, is a critical business competency. In addition, the fact that digital services are often co-produced by both service providers and their customers, shows the increasing role of both service providers and customers in preventing digital service failures (or service problems). In this study, we view the concept of digital service failure from the perspective of expectation-conformation theory, develop an Archimate architecture model and use it to design a typology of technological enablers (technologies and technological approaches) that can be used by businesses and their customers to prevent service failures at different stages of online purchase via e-commerce websites. The typology is relevant and useful for management information systems (MIS) academics and practitioners, particularly for information technology and digital service management researchers and the practitioner community.
Access to Justice vs Access to Justice for Small and Medium-sized Enterprizes: The Case for a Bilateral Arbitration Treaty
Authors: Butler Petra , Herbert C
Published: July 2020

No description supplied
PENGEMBANGAN MODUL PEMBELAJARAN SENI RUPA KOMPETENSI DESAIN POSTER UNTUK SMA
Authors: Nurfadilah Nurfadilah , Arifin Irfan , Ahmad Abd Aziz
Published: July 2020

Penelitian ini bertujuan: untuk membuat modul pembelajaran desain poster yang mengacu pada model pengembangan 4-D. Modul ini diperuntukkan bagi siswa Sekolah Menengah Atas, berisi materi tentang teknik mendesain poster. Responden yang terlibat pada penelitian pengembangan ini adalah 2 (dua) orang yaitu ahli materi dan ahli media. Data yang digali dalam penelitian ini adalah data validasi dari dosen ahli materi dan ahli media berupa aspek isi materi, aspek tampilan sampul (cover), dan aspek tampilan isi. Analisis data pada penelitian ini menggunakan teknik analisis deskriptif kuantitatif yang dikonversikan ke data kualitatif. Hasil penelitian menunjukkan bahwa nilai yang diperoleh dari validasi ahli terhadap aspek isi, aspek tampilan sampul (cover), dan aspek tampilan isi pada modul yang dikembangkan keseluruhan masuk dalam kategori bagus dan jelas, dengan rata-rata nilai aspek isi 4.43 atau 34,1%, aspek tampilan sampul 4.14 atau 31.8%, dan aspek tampilan isi 4.13 atau 34.1% yang jika dikonverskan dari rata-ratanya 4.23 untuk keseluruhan aspek modul mendapat nilai B dengan ketegori  “Jelas dan Bagus”. Sesuai dengan kriteria yang telah ditentukan, yaitu jika hasil penilaian ahli materi dan media dinyatakan baik maka produk yang dikembangkan telah memenuhi persyaratan dan layak digunakan sebagai media pembelajaran desain poster untuk siswa Sekolah Menengah Atas.
SENIMAN DAN JIWA ZAMAN: Tinjauan Perspektif Ide dan Proses Kreativitas Popo Iskandar
Authors: M Yabu
Published: July 2020

Penelitian ini mengkaji karya-karya Popo Iskandar yang dibuat sejak tahun 1960-an hingga 1990-an guna menelusuri gagasan yang melandasi penciptaan karyanya, proses kreativitas, citra dan pemikiran-pemikirannya. Teknik pengumpulan datanya dilakukan melalui penelaahan pustaka, katalog pameran, dan pengamatan. Analisis datanya menggunakan teknik analisis deskriptif-kualitatif melalui pendekatan interpretatif. Hasil penelitian menunjukkan bahwa (1) konsep yang mendasari penciptaan karya-karya Popo Iskandar adalah keteguhannya dalam menerapkan sistem nilai keabadian seni secara universal, (2) Popo Iskandar melukis berdasarkan ingatan terhadap pengalaman pribadinya, berdasarkan imajinasi dan perasaannya untuk mengungkap misteri alam dan kehidupan dengan latar belakang sosial-budaya yang diungkapkan melalui bentuk-bentuk deformatif, (3) karya-karya Popo Iskandar dapat dikelompokkan ke dalam karya representatif, abstraksi dan esensi, sedangkan tema utama yang sering muncul dalam karyanya adalah kucing, macan tutul, ayam jago, kuda, dan sosok manusia, (4) hampir setiap karya Popo Iskandar selalu terdapat gambar bulan atau matahari sebagai imbangan komposisi – sekaligus sebagai ciri khasnya.
PERANCANGAN BUKU ILUSTRASI CERITA RAKYAT LEBONNA MASSUDILALONG
Authors: Safitri Fetia , Said Abdul Azis
Published: July 2020

Perancangan ini bertujuan untuk membuat media informasi mengenai cerita rakyat atau legenda Lebonna Massudilalong di daerah Tana Toraja bagi remaja dalam bentuk buku ilustrasi. Metode perancangan yang digunakan adalah Research and Development atau penelitian dan pengembangan. Model pengembangan yang digunakan adalah model 4-D yaitu Define (pendefinisian), Design (perancangan), Develop (pengembangan) dan Disseminate (penyebaran). Namun, langkah-langkah penelitian yang dilakukan hanya (1) Define (pendefinisian), (2) Design (perancangan). Data penelitian didapatkan dari data pustaka, data dari narasumber ahli cerita dan ahli visual serta tanggapan siswa-siswi sekolah menengah atas terhadap materi komunikasi cerita rakyat Lebonna Massudilalong. Adapun konsep perancangan yakni antara lain, memilih versi cerita, menyiapkan sinopsis dan narasi cerita, membuat storyline dan storyboard, m embuat konsep karakter, membuat sketsa ilustrasi cerita, digitalisasi, dan layout, serangkaian finalisasi akhir untuk memperkenalkan dan menarik perhatian serta minat remaja terhadap produk yang dibuat.Hasil perancangan ini berupa ilustrasi cerita rakyat Lebonna Massudilalong dengan buku fisik sebagai media utamanya. Sedangkan untuk media pendukung yang berfungsi sebagai media penyalur informasi dan publikasi yaitu berupa poster, x-banner, totebag, mug, sticker, t-shirt, dan gantungan kunci
Doświadczanie rzeczywistości szkolnej przez uczniów edukacji początkowej
Authors: Michalak Renata
Published: July 2020

The teacher, especially at the stage of primary education, has a significant impact on the child’s development. The research intends to seek an answer to the main problem: How do early school teachers organize the education process for students due to key competences important for their functioning at subsequent stages of education? For that purpose, the experience of 387 children was examined in the following areas: possibilities of carrying out tasks in group work; the presence of outdoor education in school’s everyday life; the participation of experts from outside the school in the implementation of school tasks; using students’ various teaching resources, including multimedia, and undertaking research tasks. According to the following research results, teachers do not create conditions conducive to the acquisition of key competences by the students for their important function in the present and the future in school and beyond.