bluuebunny/crossref_metadata_2025 huggingface dataset:
Definition of an Intramolecular Eu‐to‐Eu Energy Transfer within a Discrete [Eu2L] Complex in Solution
Authors: Nonat Aline , Regueiro‐Figueroa Martín , Esteban‐Gómez David , de Blas Andrés , Rodríguez‐Blas Teresa , Platas‐Iglesias Carlos , Charbonnière Loïc J.
Published: May 2012

Ligand L, based on two do3a moieties linked by the methylene groups of 6,6′‐dimethyl‐2,2′‐bipyridine, was synthesized and characterized. The addition of Ln salts to an aqueous solution of L (0.01 M Tris‐HCl, pH 7.4) led to the successive formation of [LnL] and [Ln2L] complexes, as evidenced by UV/Vis and fluorescence titration experiments. Homodinuclear [Ln2L] complexes (Ln=Eu, Gd, Tb, Yb, and Lu) were prepared and characterized. The 1H and 13C NMR spectra of the Lu and Yb complexes in D2O solution (pD=7.0) showed C1 symmetry of these species in solution, pointing to two different chemical environments for the two lanthanide cations. The analysis of the chemical shifts of the Yb complex indicated that the two coordination sites present square antiprismatic (SAP) coordination environments around the metal ions. The spectroscopic properties of the [Tb2L] complex upon ligand excitation revealed conventional behavior with τH2O=2.05(1) ms and ϕH2O=51 %, except for the calculation of the hydration number obtained from the luminescent lifetimes in H2O and D2O, which pointed to a non‐integer value of 0.6 water molecules per TbIII ion. In contrast, the Eu complex revealed surprising features such as: 1) the presence of two and up to five components in the 5D0→7F0 and 5D0→7F1 emission bands, respectively; 2) marked differences between the normalized spectra obtained in H2O and D2O solutions; and 3) unconventional temporal evolution of the luminescence intensity at certain wavelengths, the intensity profile first displaying a rising step before the occurrence of the expected decay. Additional spectroscopic experiments performed on [Gd2−xEuxL] complexes (x=0.1 and 1.9) confirmed the presence of two distinct Eu sites with hydration numbers of 0 (site I) and 2 (site II), and showed that the unconventional temporal evolution of the emission intensity is the result of an unprecedented intramolecular Eu‐to‐Eu energy‐transfer process. A mathematical model was developed to interpret the experimental data, leading to energy‐transfer rates of 0.98 ms−1 for the transfer from the site with q=0 to that with q=2 and vice versa. Hartree–Fock (HF) and density functional theory (DFT) calculations performed at the B3LYP level were used to investigate the conformation of the complex in solution, and to estimate the intermetallic distance, which provided Förster radii (R0) values of 8.1 Å for the energy transfer from site I to site II, and 6.8 Å for the reverse energy transfer. These results represent the first evidence of an intramolecular energy‐transfer equilibrium between two identical lanthanide cations within a discrete molecular complex in solution.
DOTAGA–Anhydride: A Valuable Building Block for the Preparation of DOTA‐Like Chelating Agents
Authors: Bernhard Claire , Moreau Mathieu , Lhenry Damien , Goze Christine , Boschetti Frédéric , Rousselin Yoann , Brunotte François , Denat Franck
Published: May 2012

A DOTA derivative that contains an anhydride group was readily synthesized by reacting DOTAGA with acetic anhydride and its reactivity was investigated. Opening the anhydride with propylamine led to the selective formation of one of two possible regioisomers. The structure of the obtained isomer was unambiguously determined by 1D and 2D NMR experiments, including COSY, HMBC, and NOESY techniques. This bifunctional chelating agent offers a convenient and attractive approach for labeling biomolecules and, more generally, for the synthesis of a large range of DOTA derivatives. The scope of the reaction was extended to prepare DOTA‐like compounds that contained various functional groups, such as isothiocyanate, thiol, ester, and amino acid moieties. This versatile building block was also used for the synthesis of a bimodal tag for SPECT or PET/optical imaging.
Piezochromism in Nickel Salicylaldoximato Complexes: Tuning Crystal‐Field Splitting with High Pressure
Authors: Byrne Peter J. , Richardson Patricia J. , Chang John , Kusmartseva Anna F. , Allan David R. , Jones Anita C. , Kamenev Konstantin V. , Tasker Peter A. , Parsons Simon
Published: May 2012

The crystal structures of bis(3‐fluoro‐salicylaldoximato)nickel(II) and bis(3‐methoxy‐salicylaldoximato)nickel(II) have been determined at room temperature between ambient pressure and approximately 6 GPa. The principal effect of pressure is to reduce intermolecular contact distances. In the fluoro system molecules are stacked, and the Ni⋅⋅⋅Ni distance decreases from 3.19 Å at ambient pressure to 2.82 Å at 5.4 GPa. These data are similar to those observed in bis(dimethylglyoximato)nickel(II) over a similar pressure range, though contrary to that system, and in spite of their structural similarity, the salicyloximato does not become conducting at high pressure. Ni–ligand distances also shorten, on average by 0.017 and 0.011 Å for the fluoro and methoxy complexes, respectively. Bond compression is small if the bond in question is directed towards an interstitial void. A band at 620 nm, which occurs in the visible spectrum of each derivative, can be assigned to a transition to an antibonding molecular orbital based on the metal 3d(x2−y2) orbital. Time‐dependent density functional theory calculations show that the energy of this orbital is sensitive to pressure, increasing in energy as the Ni–ligand distances are compressed, and consequently increasing the energy of the transition. The resulting blueshift of the UV‐visible band leads to piezochromism, and crystals of both complexes, which are green at ambient pressure, become red at 5 GPa.
Strapped‐Porphyrin‐Based Molecular Turnstiles
Authors: Lang Thomas , Graf Ernest , Kyritsakas Nathalie , Hosseini Mir Wais
Published: May 2012

The synthesis of a series of molecular turnstiles that contained both H‐bond‐donor and ‐acceptor sites was achieved. Their structures were based on tetra‐aryl X2SnIV porphyrins (X=Cl or OH) as H‐bond‐acceptor sites that were equipped with a rotor that contained a pyridyldiamide moiety as a H‐bond donor. In the solution phase, 1D and 2D NMR spectroscopic analysis showed that switching between the closed state, which resulted from the formation of intramolecular H‐bonds, and the open state of the turnstile was achieved by using external H‐bond‐acceptor molecules, such as DMSO. The solid‐state structure of the closed state of the turnstile was established by single‐crystal X‐ray diffraction.
Controlling the Size and Morphology of Au@Pd Core–Shell Nanocrystals by Manipulating the Kinetics of Seeded Growth
Authors: Li Jing , Zheng Yiqun , Zeng Jie , Xia Younan
Published: May 2012

This article reports a systematic study of the seed‐mediated growth of Au@Pd core–shell nanocrystals with a variety of controlled sizes and morphologies. The key to the success of this synthesis is to manipulate the reaction kinetics by tuning a set of reaction parameters, including the type and concentration of capping agent, the amount of ascorbic acid used as the reducing agent, and the injection rate used for the precursor solution. Starting from Au nanospheres of 11 nm in diameter as the seeds, Au@Pd core–shell nanocrystals with a number of morphologies, including octahedra, concave octahedra, rectangular bars, cubes, concave cubes, and dendrites, could all be obtained by simply altering the reaction rate. For the first time, it was possible to generate Au@Pd nanocrystals with concave structures on the surfaces while their sizes were kept below 20 nm. In addition, the as‐prepared Au@Pd nanocubes can be used as seeds to generate Au@Pd@Au and Au@Pd@Au@Pd nanocrystals with multishelled structures.
ChemInform Abstract: 7Li and 29Si Solid State NMR and Chemical Bonding of La2Li2Si3.
Authors: Langer Thorsten , Dupke Sven , Eckert Hellmut , Matar Samir F. , Winter Martin , Poettgen Rainer
Published: May 2012

The title compound is synthesized from the elements (flowing Ar, Nb ampule, 1000 K, 48 h) and characterized by powder and single crystal XRD, 7Li and 29Si MAS NMR spectroscopy, and DFT electronic structure calculations.
ChemInform Abstract: Crystal Structure and Impedance Study of Samarium Substituted Perovskite: La1‐xSmxMnO3 (x: 0.1—0.3).
Authors: Chourasia Rashmi , Shrivastava O. P.
Published: May 2012

La1‐xSmxMnO3 (x = 0.1, 0.2, 0.3) ceramics are prepared from stoichiometric mixtures of La(NO3)3, Sm2O3, and MnCO3 (Pt crucible, 1200 °C, 12 h) and characterized by powder XRD, SEM, FTIR spectroscopy, and impedance measurements.
ChemInform Abstract: Synthesis of Nanometric LiMnPO4 via a Two‐Step Technique.
Authors: Pivko Maja , Bele Marjan , Techernychova Elena , Logar Natasa Zabukovec , Dominko Robert , Gaberscek Miran
Published: May 2012

LiMnPO4 particles with a size of 15—20 nm embedded in a carbon matrix are prepared as cathode materials for Li ion batteries from solutions of Mn(OAc)2, citric acid, and H3PO4 (Ar, 700 °C, 1 h) avoiding the presence of Li in the first step, followed by mixing the product with LiOH and thermal treatment at 700 °C for 12 h in Ar.
ChemInform Abstract: Facile Solvothermal Synthesis of Phase‐Pure Cu4O3 Microspheres and Their Lithium Storage Properties.
Authors: Zhao Lirun , Chen Han , Wang Yingli , Che Hongwei , Gunawan Poernomo , Zhong Ziyi , Li Hong , Su Fabing
Published: May 2012

Cu4O3 microspheres with diameters of 2—10 μm are solvothermally synthesized from Cu(NO3)2·3H2O dissolved in a mixture of DMF and EtOH (autoclave, 130 °C, 9 h) and characterized by XRD, SEM, TEM, XPS, and electrochemical measurements.
ChemInform Abstract: Elusive Fluoro Sulfinyl Nitrite, FS(O)NO, Produced by Photolysis of Matrix‐Isolated FS(O)2N.
Authors: Zeng Xiaoqing , Beckers Helmut , Neuhaus Patrik , Grote Dirk , Sander Wolfram
Published: May 2012

Triplet fluoro sulfonyl nitrene, FS(O)2N is generated by ArF excimer laser irradiation (λ = 193 nm) of FS(O)2N3 isolated in solid noble gas matrices.
ChemInform Abstract: Fluorination of closo,closo‐[B21H18]‐ with aHF and F2 to Yield closo,closo‐[B21H18‐xFx]‐ (x = 1—3) and closo,closo‐[B21F18]‐.
Authors: Schlueter Florian , Bernhardt Eduard
Published: May 2012

The reaction of [B21H18]‐ with anhydrous HF at 100 °C is studied.
ChemInform Abstract: Rapid Microwave Preparation of Highly Efficient Ce3+‐Substituted Garnet Phosphors for Solid State White Lighting.
Authors: Birkel Alexander , Denault Kristin A. , George Nathan C. , Doll Courtney E. , Hery Bathylle , Mikhailovsky Alexander A. , Birkel Christina S. , Hong Byung‐Chul , Seshadri Ram
Published: May 2012

Ce‐substituted Y3Al5O12 and Lu3Al5O12 garnet phosphors are prepared by microwave heating of mixtures of Y2O3 or Lu2O3, Al2O3, CeO2, and small amounts of NH4F as flux using mixtures of granular and powdered carbon as microwave susceptor.
ChemInform Abstract: {Sn10[Si(SiMe3)3]5}‐: An Anionic Metalloid Tin Cluster from an Isolable SnI Halide Solution.
Authors: Schrenk Claudio , Helmlinger Jens , Schnepf Andreas
Published: May 2012

A metastable, dark red solution of SnICl is prepared by reaction of Sn and HCl at 1240 °C followed by condensing the product at ‐196 °C with a mixture of toluene and PBu3 (10:1) and warming to ‐78 °C.
ChemInform Abstract: Reaction Products of Titanium(IV) Sulfate with the Two, Dimeric Precursors, 1,2,3‐Tri‐titanium(IV)‐ and 1,2‐Di‐titanium(IV)‐Substituted α‐Keggin Polyoxometalates (POMs), under Acidic Conditions. A Tetra‐titanium(IV) Oxide Cluster and One Coordinated Sulfate Ion Grafted on a Di‐lacunary Keggin POM.
Authors: Nomiya Kenji , Mouri Yuki , Sakai Yoshitaka , Matsunaga Satoshi
Published: May 2012

The new compound (III) containing a tetra‐titanium(IV) oxide cluster and one coordinated sulfate ion grafted on a di‐lacunary Keggin polyoxometalate is obtained from reactions of (II) with two precursors (I) and (IV) under strongly acidic conditions.
ChemInform Abstract: Organocatalytic “Difficult” Michael Reaction of Ketones with Nitrodienes Utilizing a Primary Amine—Thiourea Based on Di‐tert‐butyl Aspartate.
Authors: Tsakos Michail , Kokotos Christoforos G.
Published: May 2012

A novel aspartate‐based bifunctional thiourea—diamine organocatalyst is successfully applied in the asymmetric Michael addition of aryl methyl ketones (II), (IV) as well as acetone (VI) with nitrodienes (I).
ChemInform Abstract: Differentiation of Diastereotopic Bromine Atoms in SN2 Reactions of gem‐Dibromides.
Authors: Muenster Niels , Harms Klaus , Koert Ulrich
Published: May 2012

The reaction of gem‐dibromides (I) with sulfinate (II) is studied.
ChemInform Abstract: Organocatalytic Asymmetric Synthesis of 3‐Difluoroalkyl 3‐Hydroxyoxindoles.
Authors: Liu Yun‐Lin , Zhou Jian
Published: May 2012

Chinchona alkaloid derived urea and thiourea derivatives are successfully applied as catalysts in the enantioselective preparation of difluorinated oxindoles such as (III) and (VII).
ChemInform Abstract: Novel 1,3,4‐Heterodiazole Analogues: Synthesis and in vitro Antitumor Activity.
Authors: Taher Azza T. , Georgey Hanan H. , El‐Subbagh Hussein I.
Published: May 2012

Acylation of the amino group of (I) and subsequent cyclization on N‐3 afford the annulated imidazooxa/thiadiazolones (III) and (V) while reaction of (I) with malononitrile (VI) in the presence of a calculated amount of triethylamine yields the oxa/thiadiazolopyrimidines (VII).
ChemInform Abstract: Tandem Platinum Dichloride Catalysis and Thermal Reaction of Enynes: Versatile Synthetic Platform Based on Bicyclo[4.1.0]hept‐2‐enes.
Authors: Kim Sun Young , Park Yujung , Son Sori , Chung Young Keun
Published: May 2012

A new tandem PtCl2‐catalyzed cycloisomerization and rearrangement reaction of enynes leads to dienals, aryl‐tetrahydro‐1H‐indenes or methylenevinylcyclohexenes depending on the substituents.
ChemInform Abstract: Hofmann‐Type Rearrangement of Imides by in situ Generation of Imide‐Hypervalent Iodines(III) from Iodoarenes.
Authors: Moriyama Katsuhiko , Ishida Kazuma , Togo Hideo
Published: May 2012

The title reaction allows a new and mild access to various amino acid and anthranilic acid derivatives.
ChemInform Abstract: Reaction of Acetals with Various Carbon Nucleophiles under Non‐Acidic Conditions: C—C Bond Formation via a Pyridinium‐Type Salt.
Authors: Fujioka Hiromichi , Yahata Kenzo , Hamada Tomohito , Kubo Ozora , Okitsu Takashi , Sawama Yoshinari , Ohnaka Takuya , Maegawa Tomohiro , Kita Yasuyuki
Published: May 2012

Acetals react with various C‐nucleophiles like organocuprates, silyl enol ethers, enamines, and (iso)cyanides via intermediary pyridinium salts.
ChemInform Abstract: Oxidative Mizoroki—Heck‐Type Reaction of Arylsulfonyl Hydrazides for a Highly Regio‐ and Stereoselective Synthesis of Polysubstituted Alkenes.
Authors: Yang Fu‐Lai , Ma Xian‐Tao , Tian Shi‐Kai
Published: May 2012

The reaction tolerates a wide variety of functional groups.
ChemInform Abstract: Synthesis of (E)‐Vinyl Iodides via Pd‐Catalyzed Hydrostannation of Terminal Alkynes.
Authors: Darwish Alla , Chong J. Michael
Published: May 2012

A highly regioselective and simple one‐pot method for the synthesis of the title compounds is developed.
ChemInform Abstract: Asymmetric Synthesis of Cyclobutanones: Synthesis of Cyclobut‐G.
Authors: Darses Benjamin , Greene Andrew E. , Poisson Jean‐Francois
Published: May 2012

A simple and efficient method to prepare cis‐ and trans‐disubstituted cyclobutanones is reported.
ChemInform Abstract: TIPSOTf‐Promoted Tandem Reaction Through Rearrangement of Epoxides into Aldehydes with Selective Alkyl Migration Followed by Prins‐Type Cyclization to Cyclopentanes.
Authors: Kodama Takeshi , Harada Shingo , Tanaka Takeshi , Tachi Yoshimitsu , Morimoto Yoshiki
Published: May 2012

The intermediate aldehydes undergo direct cyclization to the ajacent isoprenyl substituent to give cyclopentane derivatives with moderate diastereoselectivity.
ChemInform Abstract: Hydroxy‐Rhodium(I) Catalyzed Regioselective Michael Addition of Cyclic Enones.
Authors: Kumaraswamy Gullapalli , Rambabu Dasa
Published: May 2012

The method is even suitable for base‐sensitive highly substituted enones.
ChemInform Abstract: Cyclopropylmethyl Palladium Species from Carbene Migratory Insertion: New Routes to 1,3‐Butadienes.
Authors: Zhou Lei , Ye Fei , Zhang Yan , Wang Jianbo
Published: May 2012

Both iodides and bromides can be used with similar results, whereas with chlorides the yields are significantly reduced.
ChemInform Abstract: Synthesis of Conjugated Allenes Through Copper‐Catalyzed γ‐Selective and Stereospecific Coupling Between Propargylic Phosphates and Aryl‐ or Alkenylboronates.
Authors: Yang Mingyu , Yokokawa Natsumi , Ohmiya Hirohisa , Sawamura Masaya
Published: May 2012

The reaction in the absence of H2O produces a complex mixture.
ChemInform Abstract: Selective Palladium‐Catalyzed C—F Activation/Carbon—Carbon Bond Formation of Polyfluoroaryl Oxazolines.
Authors: Yu Daohong , Shen Qilong , Lu Long
Published: May 2012

In the presence of PdCl2(MeCN)2/dppf, some polyfluorophenyl oxazolines are found to undergo efficient Suzuki—Miyaura reaction with aryl and vinylboronic acids to afford ortho‐substituted derivatives.
ChemInform Abstract: Zinc‐Mediated Highly α‐Regioselective Prenylation of Imines with Prenyl Bromide.
Authors: Zhao Li‐Ming , Zhang Shu‐Qing , Jin Hai‐Shan , Wan Li‐Jing , Dou Fei
Published: May 2012

A temperature of 120°C is necessary to keep the high α‐regioselectivity and to inhibit the undesired γ‐addition.
ChemInform Abstract: Direct Chemoselective Allylation of Inert Amide Carbonyls
Authors: Oda Yukiko , Sato Takaaki , Chida Noritaka
Published: May 2012

as an efficient access to various tertiary and secondary homoallylic amines
ChemInform Abstract: Amination of Electron‐Deficient Aryl Chlorides Promoted by Nanosized Mg(OH)2 under Transition Metal Free Conditions.
Authors: Cui Zhi Hao , Meng Zi Hui , Mi Yan Qing , Wang Peng , Wang Qi , Zhao Lin Man , Cui Ke Jian , Yu Fang , Xu Zhi Bin
Published: May 2012

The simple protocol allows the direct amination of acetophenone and benzophenone bearing a p‐chloro substituent with cyclic secondary amines.
ChemInform Abstract: Broensted Acid Catalyzed Asymmetric Propargylation of Aldehydes.
Authors: Jain Pankaj , Wang Hao , Houk Kendall N. , Antilla Jon C.
Published: May 2012

Under optimized conditions, aromatic or aliphatic aldehydes are propargylated by allenylboronic ester in the presence of a chiral phosphoric acid catalyst to give homopropargylic alcohols with up to 96% enantioselectivity.
ChemInform Abstract: Expedient One‐Pot Synthesis of N‐Aryliminoethers via Mild Electrophilic Activation of Secondary Amides.
Authors: Ghandi Mehdi , Hasani Mohammad , Salahi Saleh
Published: May 2012

The direct transformation of various secondary amides into N‐aryliminoethers (III) and (V) is achieved via mild electrophilic activation with triflic anhydride in the presence of 2‐chloropyridine as base.
ChemInform Abstract: Direct Asymmetric Aldol Reactions in Water Catalyzed by a Highly Active C2‐Symmetrical Bisprolinamide Organocatalyst.
Authors: Delaney Joshua P. , Henderson Luke C.
Published: May 2012

A new organocatalyst is used for reactions of cyclohexanone and cyclopentanone in water, performed with low catalyst loadings and without any additives and co‐catalysts.
ChemInform Abstract: Copper‐Catalyzed Direct Oxidative Synthesis of α‐Ketoamides from Aryl Methyl Ketones, Amines, and Molecular Oxygen.
Authors: Du Feng‐Tian , Ji Jian‐Xin
Published: May 2012

The method is limited to aryl/heteroaryl methyl ketones, and cyclic or acyclic amines.
ChemInform Abstract: Convenient and Useful Esterification of Bulky Tertiary Alcohols Using Strontium Compounds.
Authors: Miyoshi Norikazu , Asaoka Masashi , Miyazaki Yasuaki , Tajima Takahiro , Kikuchi Makoto , Wada Makoto
Published: May 2012

The reaction of various esters with metallic Sr and alkyl iodides followed by adding acid chlorides or anhydrides affords the corresponding bulky tertiary alcohol esters in good yields.
ChemInform Abstract: Aerobic Oxidation of Thiols to Disulfides by Heterogeneous Gold Catalysts.
Authors: Corma Avelino , Rodenas Tania , Sabater Maria J.
Published: May 2012

Aromatic thiols (I) and naturally occurring ones, i.e.
ChemInform Abstract: Ligand‐Free Ni‐Catalyzed Reductive Cleavage of Inert Carbon—Sulfur Bonds.
Authors: Barbero Nekane , Martin Ruben
Published: May 2012

Based on benzenethiol (XIII), a functionalization in the ortho‐ and para‐positions succeeds without a special ortho‐directing group.
ChemInform Abstract: Rhodium‐Catalyzed Cleavage Reaction of Aryl Methyl Ethers with Thioesters.
Authors: Arisawa Mieko , Nihei Yuri , Suzuki Takaaki , Yamaguchi Masahiko
Published: May 2012

The Rh‐catalyzed treatment of aryl methyl ethers with appropriate thioesters results in formation of aryl esters, accompanied by methyl sulfides such as (IV).
ChemInform Abstract: Selective Oxidation of Organic Sulfides by Mononuclear and Dinuclear Peroxotungsten(VI) Complexes.
Authors: Das Siva Prasad , Boruah Jeena Jyoti , Chetry Hiran , Islam Nashreen S.
Published: May 2012

A neutral monomeric peroxotungsten complex (I) as well as anionic dinuclear analogues (II) and (III) are found to be stoichiometric reagents for the highly selective oxidation of diorganyl sulfides to sulfoxides or sulfones, depending on the reagent ratio.
ChemInform Abstract: Transition‐Metal‐Free Direct Arylation of Anilines.
Authors: Pirali Tracey , Zhang Fengzhi , Miller Anna H. , Head Jenna L. , McAusland Donald , Greaney Michael F.
Published: May 2012

The method uses in situ generated benzynes to synthesize aminobiaryls.
ChemInform Abstract: An Efficient Stille Cross‐Coupling Reaction Catalyzed by ortho‐Palladated Complex of Tribenzylamine under Microwave Irradiation.
Authors: Hajipour Abdol R. , Karami Kazem , Rafiee Fatemeh
Published: May 2012

In contrast to aryl iodides and bromides, less reactive aryl chlorides require longer reaction times.
ChemInform Abstract: An Environmentally Friendly Synthesis of Michler′s Ketone Analogues in Water.
Authors: Shirinian Valerii Z. , Shimkin Alexey A. , Lonshakov Dmitry V. , Mailyan Artur K. , Lvov Andrey G. , Krayushkin Michail M.
Published: May 2012

A simple synthesis of the analogue (VII) of Michler′s ketone and a variety of related compounds is achieved by nucleophilic substitution of aromatic fluorine with cyclic secondary aliphatic amines in refluxing water.
ChemInform Abstract: Synthesis of 1,3‐Diarylpropenes Through Palladium‐Catalyzed Mizoroki—Heck and Allyl Cross‐Coupling Reactions Using Hydrazones as Ligands.
Authors: Mino Takashi , Koizumi Tomoko , Suzuki Saori , Hirai Kiminori , Kajiwara Kenji , Sakamoto Masami , Fujita Tsutomu
Published: May 2012

The method renders possible the access to various unsymmetrical target compounds as exclusive (E)‐isomers.
ChemInform Abstract: Dimerization of Terminal Arylalkynes in Aqueous Medium by Ruthenium and Acid Promoted (RAP) Catalysis: Acetate‐Assisted (sp)C—(sp2)C Bond Formation.
Authors: Coniglio Alessandra , Bassetti Mauro , Garcia‐Garrido Sergio E. , Gimeno Jose
Published: May 2012

Dimerization of terminal arylalkynes (I) proceeds under heterogeneous conditions affording enyne derivatives (II) with high (E)‐selectivity.
ChemInform Abstract: Site‐Selective Sonogashira Reactions of 1,4‐Dibromo‐2‐fluorobenzene — Synthesis and Properties of Fluorinated Alkynylbenzenes.
Authors: Reimann Sebastian , Sharif Muhammad , Hein Martin , Villinger Alexander , Wittler Kai , Ludwig Ralf , Langer Peter
Published: May 2012

A variety of symmetrical (III) and unsymmetrical bis‐alkynylated fluorobenzenes (V) is prepared starting from dibromofluorobenzene (I) using regioselective Sonogashira cross‐coupling reactions.
ChemInform Abstract: A Copper‐ and Amine‐Free Sonogashira Reaction Employing Chlorophosphine as New and Efficient Ligand.
Authors: Mai Wen Peng , Yuan Jin Wei , Li Zhi Cheng , Sun Gang Chun
Published: May 2012

It is shown that the sterically congested CPP is an efficient ligand for the Sonogashira coupling of aryl bromides.
ChemInform Abstract: Efficient Palladium‐Catalyzed Cross‐Coupling Reaction of Alkynyl Halides with Organoboronic Acids under Aerobic Conditions.
Authors: Tang Jian‐Sheng , Tian Mi , Sheng Wen‐Bing , Guo Can‐Cheng
Published: May 2012

A general protocol is developed for the synthesis of unsymmetrical diarylalkynes by Suzuki—Miyaura cross‐coupling of different alkynyl halides with boronic acids under ligand‐free conditions.
ChemInform Abstract: Gold‐Catalyzed Furan/Yne Cyclizations for the Regiodefined Assembly of Multisubstituted Protected 1‐Naphthols.
Authors: Wang Chengyu , Chen Yifeng , Xie Xin , Liu Jun , Liu Yuanhong
Published: May 2012

A mild and highly efficient approach to protected 1‐naphthols having enal or enone moieties is reported.
ChemInform Abstract: Synthesis of α‐Indanones via Intramolecular Direct Arylation with Cyclopropanol‐Derived Homoenolates.
Authors: Rosa David , Orellana Arturo
Published: May 2012

Optimal reaction conditions are found for the palladium‐catalyzed transformation of tetrasubstituted cyclopropane derivatives (I) and (III) into α‐indanones (II) and (IV).
ChemInform Abstract: Heterocyclic Analogues of 5,12‐Naphthacenequinone. Part 10. Synthesis of Furanoquinizarine and Its New Derivatives.
Authors: Tikhomirov A. S. , Shchekotikhin A. E. , Luzikov Yu. N. , Korolev A. M. , Preobrazhenskaya M. N.
Published: May 2012

Starting from the hitherto unknown salicylaldehyde analogue (I), the targeted 4,11‐dihydroxyanthra[2,3‐b]furan‐5,10‐dione (VII) is obtained in a 5‐step procedure.
ChemInform Abstract: A Facile Domino Protocol for the Stereoselective Synthesis of trans‐2,3‐Dihydrobenzofurans and cis‐5,6‐Dihydrofuro[2,3‐d]pyrimidines.
Authors: Vinosha Beermohamed , Perumal Subbu , Renuga Subbiah , Almansour Abdulrahman I.
Published: May 2012

Cyclocondensation of cyclohexanediones with sulfonylbispropenones under microwaves offers a selective route to trans‐2,3‐disubstituted dihydrofurans (III) in good yields.
ChemInform Abstract: Catalytic Asymmetric [3 + 2] Annulation of Allylsilanes with Isatins: Synthesis of Spirooxindoles.
Authors: Hanhan Nadine V. , Ball‐Jones Nicolas R. , Tran Ngon T. , Franz Annaliese K.
Published: May 2012

In the presence of chiral ScCl2(SbF6)·BIOP, prepared in situ, and TmsCl as an essential promoter, the desired spirooxindoles are obtained with excellent enantioselectivities at room temperature.
ChemInform Abstract: Friedel—Crafts 3‐(2‐Bromobenzoylation) of Indoles and Intramolecular Direct Arylation: An Efficient Route to Indenoindolones.
Authors: Guchhait Sankar K. , Kashyap Maneesh
Published: May 2012

ZrCl4‐mediated Friedel—Crafts acylation of indoles (I) with 2‐bromobenzyl chlorides followed by Pd‐catalyzed intramolecular C‐2 arylation of the resulting 3‐acylated indoles (III) offers a convenient synthesis of indenoindolones (IV).
ChemInform Abstract: Synthesis, Antimicrobial, Antimycobacterial and Structure—Activity Relationship of Substituted Pyrazolo‐, Isoxazolo‐, Pyrimido‐ and Mercaptopyrimidocyclohepta[b]indoles.
Authors: Yamuna Ezhumalai , Kumar R. Ajay , Zeller Matthias , Prasad Karnam Jayarampillai Rajendra
Published: May 2012

Claisen condensation of tetrahydrocycloheptaindolones (I) with ethyl formate (II) yields the intermediates (III) which in one‐pot addition reactions with appropriate nucleophiles afford a library of new title indoles.
ChemInform Abstract: Synthesis and QSAR Study of Novel Cytotoxic Spiro[3H‐indole‐3,2′(1′H)‐pyrrolo [3,4‐c]pyrrole]‐2,3′,5′(1H,2′aH,4′H)‐triones.
Authors: Girgis Adel S. , Stawinski Jacek , Ismail Nasser S. M. , Farag Hanaa
Published: May 2012

Pyrrolediones (III) react in a 1,3‐dipolar cycloaddition reaction with non‐stabilized azomethine ylides, generated in situ via decarboxylative condensation of isatins (I) and sarcosine (II), to afford spiro compounds (IV) in good yields.
ChemInform Abstract: N‐Aryl‐2‐phenyl‐2,3‐dihydro‐imidazo[1,2‐b]pyrazole‐1‐carboxamides 7‐Substituted Strongly Inhibiting both fMLP‐OMe‐ and IL‐8‐Induced Human Neutrophil Chemotaxis.
Authors: Brullo Chiara , Spisani Susanna , Selvatici Rita , Bruno Olga
Published: May 2012

Title compounds (VI),(VII), and (XIII) are designed and synthesized as multi‐target antiinflammatory agents.
ChemInform Abstract: Microwave‐Assisted Cerium(III)‐Promoted Cyclization of Propargyl Amides to Polysubstituted Oxazole Derivatives.
Authors: Bartoli Giuseppe , Cimarelli Cristina , Cipolletti Roberto , Diomedi Simone , Giovannini Riccardo , Mari Margherita , Marsili Laura , Marcantoni Enrico
Published: May 2012

The 5‐exo‐dig cyclization of propargylic amides proceeds efficiently in the system CeCl3—NaI—I2 under microwave irradiation to afford polysubstituted oxazoles, e.g. (II) and (IV), in moderate to high yields.
ChemInform Abstract: Tandem Migration—Carboalkoxylation of o‐Isocyanophenyl Acetals Leading to Benzoxazoles.
Authors: Okitsu Takashi , Nagase Kenta , Nishio Nobuhiko , Wada Akimori
Published: May 2012

Both a Lewis acid and base work cooperatively in the process.
ChemInform Abstract: Palladium‐Catalyzed Intramolecular Diamination of Acrylic Esters Using Sulfamates as Nitrogen Source.
Authors: Chavez Patricia , Kirsch Jonathan , Streuff Jan , Muniz Kilian
Published: May 2012

The title reaction selectively provides trans‐substituted bicyclic sulfamates of type (II), which can be converted into derivatives like (III) and (V).
ChemInform Abstract: Ru(II) Complexes Bearing Tertiary Phosphine Ligands: A Novel and Efficient Homogeneous Catalyst for One‐Pot Synthesis of Dihydropyrano[3,2‐c]chromene and Tetrahydrobenzo[b]pyran Derivatives.
Authors: Tabatabaeian Khalil , Heidari Hannaneh , Mamaghani Manouchehr , Mahmoodi Nosrat O.
Published: May 2012

The three‐component condensation results in formation of title compounds (IV) and (IX), mostly within short times.
ChemInform Abstract: A Facile Synthetic Route to 2‐Trifluoromethyl‐Substituted Polyfunctionalized Chromenes and Chromones.
Authors: Wen Lele , Zhang Honghai , Lin Hao , Shen Qilong , Lu Long
Published: May 2012

NEt3‐mediated reaction of salicylaldehydes (I) with (Z)‐butenoate (II) provides an easy access to 2‐trifluoromethylchromenols (III), which can readily be oxidized to corresponding chromones (IV).
ChemInform Abstract: CuO Nanoparticles: An Efficient and Recyclable Nanocatalyst for the Rapid and Green Synthesis of 3,4‐Dihydropyrano[c]chromenes.
Authors: Mehrabi Hossein , Kazemi‐Mireki Maryam
Published: May 2012

CuO‐nanoparticles are described as recyclable heterogeneous catalyst for the three‐component synthesis of the title compounds (IV).
ChemInform Abstract: Features of the α‐Azolyl‐2‐hydroxyacetophenones Reaction with Chloroacetyl Chloride.
Authors: Shokol T. V. , Gorbulenko N. V. , Khilya V. P.
Published: May 2012

For unknown reasons, the cyclization of title acetophenones proceeds only in the presence of thiazole rings.
ChemInform Abstract: Regioselective Synthesis of Isocoumarins by Ruthenium‐Catalyzed Aerobic Oxidative Cyclization of Aromatic Acids with Alkynes
Authors: Chinnagolla Ravi Kiran , Jeganmohan Masilamani
Published: May 2012

21 examples
ChemInform Abstract: 1,3‐Dichloro‐tetra‐n‐butyl‐distannoxane: A New Application for Catalyzing the Direct Substitution of 9H‐Xanthen‐9‐ol at Room Temperature.
Authors: Liu Ling‐yan , Zhang Yan , Huang Kai‐meng , Chang Wei‐xing , Li Jing
Published: May 2012

Tin‐catalyzed direct substitution reactions of xanthenol (II) with indoles (I) afford xanthenylindole derivatives (III) in high yields.
ChemInform Abstract: Stereoselective Piperidine Synthesis Through Oxidative Carbon—Hydrogen Bond Functionalizations of Enamides.
Authors: Brizgys Gediminas J. , Jung Hyung Hoon , Floreancig Paul E.
Published: May 2012

In the presence of DBU, N‐vinyl carbamates, sulfonamides, and amides that contain pendent π‐nucleophiles such as allylsilane, enolsilane, propargylsilane, and enol acetate, give the piperidines within minutes.
ChemInform Abstract: Facile One‐Pot Synthesis of Polysubstituted Quinolines under Solvent‐Free Conditions Using Sulfamic Acid as a Reusable Catalyst.
Authors: Zhang Min , Xiong Biao , Yang Wei , Kumar D. N. T. , Ding Yu‐Qiang
Published: May 2012

The reaction proceeds regioselectively in the case of disubstituted anilines such as (VI) or β‐naphthylamine (IV).
ChemInform Abstract: Biocatalytic Production of Tetrahydroisoquinolines.
Authors: Ruff Bettina M. , Braese S. , O'Connor Sarah E.
Published: May 2012

The enzyme is efficiently employed as biocatalyst for the synthesis of a variety of tetrahydroisoquinolines by cyclizing dopamine with aldehydes.
ChemInform Abstract: Synthesis of Annulated Pyridines by Intramolecular Inverse‐Electron‐Demand Hetero‐Diels—Alder Reaction under Superheated Continuous Flow Conditions.
Authors: Martin Rainer E. , Morawitz Falk , Kuratli Christoph , Alker Andre M. , Alanine Alexander I.
Published: May 2012

The reaction of various pyrimidine alkynes proceeds with the expulsion of cyanides and provides facile access to the novel annulated pyridine building blocks.
ChemInform Abstract: Three‐Component Spiro Heterocyclization of 1H‐Pyrrole‐2,3‐dione by the Action of 3‐Arylamino‐1H‐inden‐1‐ones.
Authors: Dmitriev M. V. , Silaichev P. S. , Aliev Z. G. , Maslivets A. N.
Published: May 2012

A previously inaccessible spiro[diindeno[1,2‐b:2′,1′‐e]pyridine‐11,3′‐pyrrole] heterocyclic system is obtained.
ChemInform Abstract: Synthesis of Novel Alkyl and Aryl Substituted Dibenzo[b,h][1,6]naphthyridines.
Authors: Manoj M. , Prasad K. J. Rajendra
Published: May 2012

Title dibenzonaphthyridines (III) can be prepared in a one‐ or two‐step procedure.
ChemInform Abstract: A Synthesis of Dihydroimidazo[5,1‐a]isoquinolines Using a Sequential Ugi—Bischler—Napieralski Reaction Sequence.
Authors: Seganish W. Michael , Bercovici Ana , Ho Ginny D. , Loozen Hubert J. J. , Timmers Cornelis M. , Tulshian Deen
Published: May 2012

The two‐step sequence is optimized to give fair yields of the biologically interesting title compounds (V).
ChemInform Abstract: Isoxazoles Incorporated N‐Substituted Decahydroquinolines: A Precursor to the Next Generation Antimicrobial Drug.
Authors: Babu Mariappan , Pitchumani Kasi , Ramesh Penugonda
Published: May 2012

A simple access to N‐substituted decahydroisoxazoloquinolines (IV) with substituents at position 3 and 4 is achieved from readily available substrates in appreciable yields.
ChemInform Abstract: One‐Pot Synthesis of 2,6‐Diamino‐4‐sulfonamidopyrimidines from Sulfonyl Azides, Terminal Alkynes and Cyanoguanidine.
Authors: Yavari Issa , Nematpour Manijeh , Ghazanfarpour‐Darjani Majid
Published: May 2012

Addition of copper acetylides to sulfonyl azides generates ketenimines which are readily trapped by cyanoguanidine to yield the pyrimidines.
ChemInform Abstract: Green Synthesis of Quinazolinone Derivatives Catalyzed by Iodine in Ionic Liquid.
Authors: Wang Shu‐Liang , Yang Ke , Yao Chang‐Sheng , Wang Xiang‐Shan
Published: May 2012

Iodine‐catalyzed cyclization of o‐aminobenzamides (I) with triethyl orthoformate (II) or triphosgene (IV) proceeds smoothly in ionic liquid as solvent to afford quinazolinones (III) and (IV) in high yields.
ChemInform Abstract: Facile and Efficient Synthesis of 3,10‐Disubstituted‐bis‐1,2,4‐triazolo[4,3‐a][3′,4′‐c]quinoxalines Using Copper Dichloride as an Oxidant.
Authors: Aggarwal Ranjana , Sumran Garima , Yadav Mamta , Anju Anju
Published: May 2012

Copper dichloride is a nontoxic, inexpensive, and readily available reagent, which offers a general access to the synthesis of bis‐triazoloquinoxalines, which are not obtainable by use of iodobenzene diacetate.
ChemInform Abstract: First Synthesis of 4‐Aminopyrido[2′,3′:4,5]furo[3,2‐d]pyrimidines.
Authors: Loidreau Yvonnick , Marchand Pascal , Dubouilh‐Benard Carole , Nourrisson Marie‐Renee , Duflos Muriel , Besson Thierry
Published: May 2012

The novel precursor (II) is prepared following the procedure published for its 6‐bromo analogue.
ChemInform Abstract: Highly Efficient and Broad‐Scope Protocol for the Preparation of 7‐Substituted 6‐Halopurines via N9‐Boc‐Protected 7,8‐Dihydropurines.
Authors: Kotek Vladislav , Tobrman Tomas , Dvortak Dalimil
Published: May 2012

It is demonstrated that a Boc‐protecting group is suitable for the synthesis of a variety of 7,9‐disubstituted derivatives which can be readily deprotected and oxidized to 7‐substituted purines in excellent overall yields.
ChemInform Abstract: Desulfurization of Pyrido[3′,2′:4,5]thieno[2,3‐f]pyrrolo[1,2‐a][1,4]diazepines.
Authors: Red'kin V. M. , Stroganova T. A. , Vasilin V. K. , Krapivin G. D.
Published: May 2012

The thieno[2,3‐b]pyridine fragment in (I) undergoes desulfurization in the presence of activated Raney nickel.
ChemInform Abstract: Rapid Synthesis of Benzodiazepines by Ring Expansion of Aziridines with Anthranilic Acids by Using a Grinding Technique.
Authors: Singh Atul K. , Yadav Lal Dhar S.
Published: May 2012

A direct synthesis of potentially pharmaceutically relevant benzo‐1,4‐diazepines is developed by LiBr‐catalyzed reaction of anthranilic acids with aziridines.
ChemInform Abstract: Preparation of Chiral Multifunctional Thiourea—Phosphanes and Synthesis of Chiral Allylic Phosphites and Phosphane Oxides Through Asymmetric Allylic Substitution Reactions of Morita—Baylis—Hillman Carbonates.
Authors: Deng Hong‐Ping , Shi Min
Published: May 2012

The reactions apply chiral multifunctional thiourea‐phosphane catalyst (TPB) to afford allylic phosphites and phosphane oxides in high yields and enantioselectivities.
ChemInform Abstract: Synthesis of Novel Heterocyclic Systems 3,9‐Dihydro‐2H‐[1,3]selenazolo[3,2‐a]benzimidazol‐4‐ium Derivatives.
Authors: Borisov A. V. , Matsulevich Zh. V. , Osmanov V. K. , Borisova G. N.
Published: May 2012

The novel fused selenazole heterocycles (V) and (VII) are formed both diastereo‐ and regioselectively.
ChemInform Abstract: Unusual Reactivity of Dimethylsulfoxonium Methylide with Esters.
Authors: Leggio Antonella , De Marco Rosaria , Perri Francesca , Spinella Mariagiovanna , Liguori Angelo
Published: May 2012

The title reaction affords the corresponding free acids after an acidic work‐up through an ester hydrolysis mechanism.
ChemInform Abstract: Rapid Access to Polycyclic Indolines Related to the Stephacidin Alkaloids Using a Radical Cascade.
Authors: Simpkins Nigel , Pavlakos Ilias , Male Louise
Published: May 2012

This radical cascade reaction initiated from sulfur‐substituted diketopiperazine (I) affords indolines as key stepping stones to avrainvillamide, stephacidin B, and their bioactive analogues.
ChemInform Abstract: Expedient Total Synthesis of Triciribine and Its Prodrugs.
Authors: Shen Wei , Kim Jae‐Seung , Hilfinger John
Published: May 2012

Key step of the novel synthesis of triciribine (VIa) is the regioselective cyanation of compound (I).
ChemInform Abstract: Design, Synthesis, Antiviral and Cytostatic Evaluation of Novel Isoxazolidine Nucleotide Analogues with a 1,2,3‐Triazole Linker.
Authors: Piotrowska Dorota G. , Balzarini Jan , Glowacka Iwona E.
Published: May 2012

Replacing the furanose ring by an isoxazolidine system and introduction of a triazole linker between isoxazolidine and the nucleobase or another aromatic function afford the title analogues (V) and (VI).
ChemInform Abstract: Four New Stilbenoids from the Orchids Coelogyne ochracea and Coelogyne cristata
Authors: Majumder P. L. , Bandyopadhyay Saswati , Pal Suparna
Published: May 2012

isolation and structure of ochracinone (Ia), ochracinanthrone (Ib), coeloginone (Ic) and coeloginanthrone (Id)
ChemInform Abstract: Metal Oxide Hollow Nanostructures for Lithium‐Ion Batteries
Authors: Wang Zhiyu , Zhou Liang , Lou Xiong Wen
Published: May 2012

Review: 76 refs.
ChemInform Abstract: Colloidal CIGS and CZTS Nanocrystals: A Precursor Route to Printed Photovoltaics
Authors: Akhavan Vahid A. , Goodfellow Brian W. , Panthani Matthew G. , Steinhagen Chet , Harvey Taylor B. , Stolle C. Jackson , Korgel Brian A.
Published: May 2012

Review: CIGS: Cu(In1‐xGax)Se2, CZTS: Cu2ZnSnS4; 63 refs.
ChemInform Abstract: Recent Developments in Asymmetric Organocatalytic Domino Reactions
Authors: Pellissier Helene
Published: May 2012

Review: ca. 200 refs.
ChemInform Abstract: Recent Developments in the Chemistry of Pyrazolo[4,3‐c]quinolines
Authors: Mekheimer Ramadan A. , Ahmed Eltaib A. , Sadek Kamal U.
Published: May 2012

Review: 124 refs.
ChemInform Abstract: Dual Super‐Electrophilic and Diels—Alder Reactivity of Neutral 10π Heteroaromatic Substrates
Authors: Terrier Francois , Dust Julian M. , Buncel Erwin
Published: May 2012

Review: ca. 100 refs.
ChemInform Abstract: Small Molecule Organic Semiconductors on the Move: Promises for Future Solar Energy Technology.
Authors: Mishra Amaresh , Baeuerle Peter
Published: May 2012

Review: 258 refs.
ChemInform Abstract: Cu‐Mediated Organic Transformations in Water
Authors: Marinelli Fabio
Published: May 2012

Review: 90 refs.
ChemInform Abstract: The Chemistry of N‐Hydroxyamidoximes, N‐Aminoamidoximes, and Hydrazidines
Authors: Katritzky Alan R. , Huang Longchuan , Chahar Mamta , Sakhuja Rajeev , Hall C. Dennis
Published: May 2012

Review: 79 refs.
ChemInform Abstract: Nafion—Silica Nanocomposites: A New Generation of Water‐Tolerant Solid Acids of High Efficiency — An Update
Authors: Molnar Arpad
Published: May 2012

Review: 182 refs.
ChemInform Abstract: Fluorine‐Containing Chiral Drugs
Authors: Qiu Xiao‐Long , Yue Xuyi , Qing Feng‐Ling
Published: May 2012

Review: 146 refs.
ChemInform Abstract: Synthesis of 1,3‐Dienes by Aldol and Related Condensation Reactions
Authors: Minbiole K. P. C.
Published: May 2012

Review: 125 refs.
ChemInform Abstract: Synthesis of 1,3‐Dienes by Alkene Metathesis
Authors: Diver S. T.
Published: May 2012

Review: 151 refs.
ChemInform Abstract: Metal‐Free Oxidative C—H Bond Amination at Ambient Temperature
Authors: Samanta Rajarshi , Antonchick Andrey P.
Published: May 2012

Review: 54 refs.
ChemInform Abstract: Development of Noncovalent Supported Ionic Liquid Phase Catalyst (SILPC) for Liquid‐Phase Reaction as a Benign and Sustainable Protocol to Immobilize Homogeneous Catalyst
Authors: Hagiwara Hisahiro
Published: May 2012

Review: ca. 100 refs.
ChemInform Abstract: Physico‐Chemical Properties and Phase Behavior of Piperidinium‐Based Ionic Liquids
Authors: Domanska Urszula , Krolikowska Marta , Paduszynski Kamil
Published: May 2012

Review: 47 refs.
ChemInform Abstract: Recent Patents on Oligonucleotide Synthesis and Gene Synthesis
Authors: Yu Tingsheng , Bao Xiao , Piao Wenxian , Peng Jingli , Li Wei , Yang Cui , Xing Meng , Zhang Yiliu , Qi Jinhuan , Xu Lei , et al. et al.
Published: May 2012

Review: 37 refs.
ChemInform Abstract: Chemistry of Steroidal Sapogenins — New Advances in a Classical Field
Authors: Jastrzebska Izabella
Published: May 2012

Review: 95 refs.
ChemInform Abstract: F. Gordon A. Stone: The Chemist′s Chemist
Authors: Maitlis Peter M. , Hill Anthony F.
Published: May 2012

Review: 110 refs.
ChemInform Abstract: Asymmetric Hydrogenation of Heteroarenes and Arenes
Authors: Wang Duo‐Sheng , Chen Qing‐An , Lu Sheng‐Mei , Zhou Yong‐Gui
Published: May 2012

Review: 177 refs.
ChemInform Abstract: Synthetic Routes to Chiral Nonracemic and Racemic Dihydro‐ and Tetrahydrothiophenes
Authors: Benetti Simonetta , De Risi Carmela , Pollini Gian P. , Zanirato Vinicio
Published: May 2012

Review: 217 refs.
ChemInform Abstract: Syntheses and Reactivity of Calixarenes Functionalized at the meso Positions
Authors: Sliwa Wanda , Deska Malgorzata
Published: May 2012

Review: 70 refs.
ChemInform Abstract: Recent Developments on Rotaxane‐Based Shuttles: An Update to 2010
Authors: Rescifina Antonio , Chiacchio Ugo , Corsaro Antonino , Romeo Giovanni
Published: May 2012

Review: 58 refs.
ChemInform Abstract: Proline‐Derived Organocatalysis and Synergism Between Theory and Experiments
Authors: Sunoj Raghavan B.
Published: May 2012

Review: 106 refs.
ChemInform Abstract: Recent Applications of gem‐Dichloroepoxide Intermediates in Synthesis
Authors: Snowden Timothy S.
Published: May 2012

Review: 67 refs.
ChemInform Abstract: Alkylidene β‐Ketoesters in Asymmetric Catalysis: Recent Developments
Authors: Schotes Christoph , Mezzetti Antonio
Published: May 2012

Review: 86 refs.
ChemInform Abstract: A Basic Tutorial on Cyclic Voltammetry for the Investigation of Electroactive Microbial Biofilms
Authors: Harnisch Falk , Freguia Stefano
Published: May 2012

Review: 52 refs.
ChemInform Abstract: Small‐Molecule Stabilization of Protein—Protein Interactions: An Underestimated Concept in Drug Discovery?
Authors: Thiel Philipp , Kaiser Markus , Ottmann Christian
Published: May 2012

Review: 62 refs.
ChemInform Abstract: Self‐Assembled Gelators for Organic Electronics
Authors: Babu Sukumaran Santhosh , Prasanthkumar Seelam , Ajayaghosh Ayyappanpillai
Published: May 2012

Review: 80 refs.
ChemInform Abstract: Applicative Performances of Fluorinated Carbons Through Fluorination Routes: A Review
Authors: Guerin Katia , Dubois Marc , Houdayer Axel , Hamwi Andre
Published: May 2012

Review: 33 refs.
ChemInform Abstract: Inorganic Material Coatings and Their Effect on Cytotoxicity
Authors: Richards David , Ivanisevic Albena
Published: May 2012

Review: 67 refs.
ChemInform Abstract: Signal Amplification Using Functional Nanomaterials for Biosensing
Authors: Lei Jianping , Ju Huangxian
Published: May 2012

Review: 64 refs.
ChemInform Abstract: Biological and Chemical Sensors Based on Graphene Materials
Authors: Liu Yuxin , Dong Xiaochen , Chen Peng
Published: May 2012

Review: 312 refs.
ChemInform Abstract: Metal—Organic Framework Growth at Functional Interfaces: Thin Films and Composites for Diverse Applications.
Authors: Bradshaw Darren , Garai Ashesh , Huo Jia
Published: May 2012

Review: 138 refs.
Synthesis of a Heparan Sulfate Mimetic Library Targeting FGF and VEGF via Click Chemistry on a Monosaccharide Template
Authors: Liu Ligong , Li Caiping , Cochran Siska , Jimmink Shane , Ferro Vito
Published: May 2012

A disulfated methyl 6‐azido‐6‐deoxy‐α‐D‐mannopyranoside template was used as a core structure for binding to the angiogenic growth factors FGF‐1, FGF‐2, and VEGF. The core structure was diversified in a rapid, parallel manner by employing the CuI‐catalyzed Huisgen azide–alkyne cycloaddition (“click”) reaction. The diversity was further extended by incorporating a Swern oxidation–Wittig reaction sequence on a click adduct of propargyl alcohol. Thus, the sulfated core was linked by various spacers to selected hydrophobic or polar motifs, which were designed to probe the protein surface surrounding the cationic heparan sulfate binding sites of the growth factors in order to improve affinity and selectivity. The affinities of the compounds for the growth factors were measured by surface plasmon resonance solution affinity assays. A lead compound was identified with micromolar binding affinity toward both FGF‐1 and VEGF (Kd=84 and 49 μM, respectively) and good selectivity over FGF‐2 (29‐ and 51‐fold, respectively).
A robust and efficient valve model based on resistive immersed surfaces
Authors: Astorino Matteo , Hamers Jeroen , Shadden Shawn C. , Gerbeau Jean‐Frédéric
Published: May 2012

A procedure for modeling the heart valves is presented. Instead of modeling complete leaflet motion, leaflets are modeled in open and closed configurations. The geometry of each configuration can be defined, for example, from in vivo image data. This method enables significant computational savings compared with complete fluid–structure interaction and contact modeling, while maintaining realistic three‐dimensional velocity and pressure distributions near the valve, which is not possible from lumped parameter modeling. Leaflets are modeled as immersed, fixed surfaces over which a resistance to flow is assigned. On the basis of local flow conditions, the resistance values assigned for each configuration are changed to switch the valve between open and closed states. This formulation allows for the pressure to be discontinuous across the valve. To illustrate the versatility of the model, realistic and patient‐specific simulations are presented, as well as comparison with complete fluid–structure interaction simulation. Copyright © 2012 John Wiley & Sons, Ltd.