bluuebunny/crossref_metadata_2025 huggingface dataset:
LAMA2 and LOXL4 Are Candidate FSGS Genes
Authors: Hack Saidah , Vijayan Poornima , Yao Tony , Qureshi Mohammad Azfar , Paterson Andrew , John Rohan , Davenport Bernard , Lennon Rachel , Pei York , Barua Moumita
Published: February 2021

Background: Focal and segmental glomerulosclerosis (FSGS) is a histologic pattern of injury that characterizes a wide spectrum of diseases. Many genetic causes have been identified in FSGS but even in families with comprehensive testing, a significant proportion remain unexplained. Results: In one FSGS family with 6 affected relatives, we performed linkage analysis and whole exome sequencing (WES). Linkage analysis narrowed the disease gene(s) to within 3% of the genome. Whole exome sequencing revealed 5 heterozygous rare variants, which were sequenced in 11 relatives where DNA was available. Two of these variants, in LAMA2 and LOXL4, remained as candidates after segregation analysis and encode extracellular matrix proteins of the glomerulus. Renal biopsies showed classic segmental sclerosis/hyalinosis lesion on a background of mild mesangial hypercellularity. Examination of basement membranes with electron microscopy showed regions of dense mesangial matrix in one individual and wider glomerular basement membrane (GBM) thickness in two individuals compared to historic control averages. Conclusions: Based on our findings, we postulate that the additive effect of digenic inheritance of heterozygous variants in LAMA2 and LOXL4 leads to adult-onset FSGS. Limitations to our study includes the absence of functional characterization to support pathogenicity. Alternatively, identification of additional FSGS cases with suspected deleterious variants in LAMA2 and LOXL4 will provide more evidence for disease causality. Thus, our report will be of interest to clinicians and genetic groups as sequencing in renal disease becomes more widespread. Overall, our results provide an example of more complicated genetic inheritance patterns that underlie glomerular disorders in unexplained families.
Fetal Lung Interstitial Tumor: Clinicopathologic Analysis of 4 Cases From China
Authors: ZhiJuan Deng , Nan Zhang , Le-jian He , Xing-feng Yao , Chao Jia , Meng Zhang
Published: February 2021

Background: The fetal lung interstitial tumor (FLIT) is a newly identified tumor and is extremely rare, with only five reports published in English. Here, we report 4 cases of FLITs in China and present a literature review, aiming to explore this rare tumor.Methods: The clinical and histological findings, immunophenotype, and ALK FISH of these 4 FLIT cases were evaluated, with a detailed review of the literature.Result: The 4 cases comprised 2 male and 2 female infants. Two cases had a lung or intrathoracic mass during pregnancy, as early as 28 gestational weeks, and tachypnea and groaning shortly after birth. The other two cases received clinical attention because of jaundice and weakness at 3 days and 10 minutes after birth. The two female patients had a high serum AFP level. CT showed a well-circumscribed solid-cystic mass in the lung. Surgical removal was performed at 6 days, 11 days, 18 days and 5 days respective. Grossly, the tumor was a well-0circumscribed, solid-to-spongy cut surface, and the largest diameter was 5.5-6.1 cm. Histological examination revealed an immature airspace and interstitium resembling fetal lung tissue at the canalicular stage (20-24 weeks of gestation). The epithelial cells coexpressed CK, EMA, TTF-1 and b-catenin, while the interstitial cells were strongly and diffusely positive for vimentin, with variable degrees of desmin, SMA, MSA and b-catenin. There was no ALK positivity among the four cases. One of the four cases had an ALK gene fusion by FISH. All four cases were in good condition after surgery.Conclusions: The FLIT is a recently reported type of congenital lung lesion with distinct pathological morphology. Some of the FLIT cases have high AFP levels, which represents an ALK gene fusion and may be related to ALK-positive tumors. The FLIT prognosis is good, and surgery is the preferred treatment. The differential diagnosis should include congenital pulmonary airway malformation (CPAM), pleuropulmonary blastoma (PPB), congenital inflammatory myofibroblastic tumor (CIMT) and pulmonary interstitial glycogenosis (PIG).
Inequality and Support for Government Responses to COVID-19
Authors: Dang Hai-Anh , Malesky Edmund , Nguyen Cuong
Published: February 2021

Despite a rich literature studying the impact of inequality on policy outcomes, there has been limited effort to bring these insights into the debates about comparative support for government responses to the COVID-19 pandemic. We fill in this gap by analyzing rich survey data from six countries spanning different income levels and geographical locations—China, Italy, Japan, South Korea, the United Kingdom, and the United States—in April 2020, when most countries were facing their first surge in infections and designing their response efforts. We find that poorer individuals are less supportive of strict government responses than other groups, and that poorest individuals are least supportive. Furthermore, poorer individuals residing in more economically unequal countries are the least supportive of stringent policies. We also find that both economic and non-economic factors could affect the poor’s decisions to support stringent government policies. These findings suggest that greater transfers to the poor may ameliorate their resistance, increase support for strict policies, and may reduce the potential deepening of social inequalities caused by the pandemic, given some recent evidence that the poor and the vulnerable are most affected by the pandemic. These findings offer relevant and implementable policy advice for the ongoing global fight against the pandemic.
Oseltamivir improved thrombocytopenia during veno-arterial extracorporeal membrane oxygenation in adults with refractory cardiac failure: A single-center retrospective real-world study
Authors: Li Yuan , Wang Lin , Zhang Jianning , Han Hui , Liu Han , Li Chaoyang , Guo Haipeng , Chen Yuguo , Chen Xiaomei
Published: February 2021

Background

Severe thrombocytopenia is a common complication of extracorporeal membrane oxygenation (ECMO). Oseltamivir can be used to treat infection-associated thrombocytopenia.
Objective

To evaluate the effect of oseltamivir on attenuating severe thrombocytopenia during ECMO.
Methods

This was a single-center real-world study in critically ill patients supported with venous-arterial extracorporeal membrane oxygenation (VA-ECMO). Patients suspected or confirmed with influenza received oseltamivir according to the Chinese guidelines. Thrombocytopenia and survival were compared between the oseltamivir-treated and -untreated groups. The factors associated with survival were analyzed by multivariable Cox analysis.
Results

A total of 82 patients were included. All patients developed thrombocytopenia after initiating VA-ECMO. Twenty-three patients received oseltamivir (O+ group), and 59 did not (O− group). During the first 8 days of VA-ECMO initiation, the platelet counts in the O+ group were higher than in the O− group (all P < 0.05). The patients in the O+ group had higher median platelet counts at the nadir (77,000/µL, 6,000-169,000/µL), compared with the O− group (49,000/µL, 2,000-168,000/µL; P = 0.04). A platelet count nadir < 50,000/µL was seen in 26% of the patients in the O+ group, compared with 53% in the O− group (P = 0.031). No significant differences in survival to discharge were seen between the O+ and O− groups (48% vs. 56%, P = 0.508). Only the Sequential Organ Failure Assessment (SOFA) scores at the time of VA-ECMO initiation were independently associated with survival (OR = 1.12, 95% confidence interval (95% CI): 1.02–1.22, P = 0.015).
Conclusions

Oseltamivir could ameliorate VA-ECMO-related thrombocytopenia. These findings suggest the prophylactical potential of oseltamivir on severe thrombocytopenia associated with the initiation of VA-ECMO.
Impact of Alpha-Adrenergic Receptor Antagonists on outcomes in patients with heart failure. A post-hoc analysis using National Health Fund database
Authors: Symonides Bartosz , Lewandowski Jacek , Śliwczyński Andrzej
Published: February 2021

BackgroundThe alpha-adrenolytics (AA) are not recommended in patients with EF reduced heart failure due to safety concerns. The aim of our study was to assess the safety of AA in patients hospitalized due to exacerbation of HF and the influence of these drugs on long-term endpoints.MethodsData collected by the National Health Fund was used. Patients hospitalized due to HF exacerbation were included. The primary outcome was all-cause mortality and the secondary was the first readmission due to HF or all-cause death occurring more than 30 days after discharge.ResultsOf 140 668 patients hospitalized in the year 2013 n=53317 were included and followed for a median of 56.3 months. AA patients had lower long-term mortality (52.8% vs. 54.9%, unadjusted P=0.038). The treatment with AA positively and affected long-term survival (adjHR 0.82, 95%CI 0.78-0.87, P<0.001), as well as secondary endpoint (adjHR 0.85, 95%CI 0.81-0.90, P<0.001).Cox analysis in the subgroup treated with beta-blockers revealed that treatment with AA was associated with lower mortality (adjHR 0.82, 95%CI 0.75-0.90, P<0.001) and lower incidence of secondary endpoint (adjHR 0.85, 95%CI 0.78-0.92, P<0.001). ConclusionsIn compliant patients hospitalized due to HF exacerbation post discharge treatment with AA was safe and beneficial.
The Anxious-Depressive Attack Severity Scale: Development and Initial Validation and Reliability
Authors: Noda Shota , MATSUMOTO Satomi , KAWASAKI Naoko , MASAKI Mina , FUKUI Itaru , KAIYA Hisanobu
Published: February 2021

Background: Anxious-depressive attack (ADA) is a symptom complex that comprises sudden intense feelings of anxiety or depression, intrusive rumination of regretful memories or future worries, emotional distress due to painful thoughts, and coping behaviors to manage emotional distress. ADA has been observed transdiagnostically across various psychiatric disorders. Although the importance of ADA treatment has been indicated, a scale to measure the severity of ADA has not been developed. This study aimed to develop the Anxious-Depressive Attack Severity Scale (ADAS) for measuring the severity of ADA symptoms and examine its reliability and validity. Methods: A total of 242 outpatients responded to a questionnaire and participated in an interview, which were designed to measure the severity of ADA, depression, anxiety, anxious depression, and social anxiety symptoms. Based on the diagnostic criteria for ADA, 54 patients were confirmed to have ADA and were included in the main study analyses. Results: The results of the exploratory factor analysis showed that the ADAS had two factors: severity of ADA symptoms and ADA frequency and coping behaviors. McDonald's ωt coefficients were high for the overall scale and the first factor (ωt = .78 and ωt = .83, respectively) but low for the second factor (ωt = .49). The ADAS score was significantly positively correlated with clinical symptoms related to anxiety and depression.Conclusion: The present study demonstrated that the ADAS had sufficient reliability and validity; however, internal consistency was insufficient for the second factor. Overall, the ADAS has potential to be a valuable tool for use in clinical trials of ADA.
Acupuncture for Oculomotor Nerve Palsy: a Systematic Review Protocol
Authors: Zhang Xiaohui , Zheng Shumei , Liu Yijiang , Du Ruosang , Yuan Hongwen , Cui Hai
Published: February 2021

Background: Oculomotor nerve palsy(ONP) is a common clinical disease in neurology and ophthalmology which results in serious syndrome such as ptosis, diplopia, and limited eye movement. The major medications treating ONP usually make sense and side effects, while acupuncture is known as a safe and effective therapy for ONP. We aim to evaluate the safety and efficacy of acupuncture in the treatment of ONP.Methods: The following database will be required from PubMed, Cochrane Library, Medline, Chinese Biomedical Literature Database, China National Knowledge Infrastructure (CNKI), Wanfang data, Chinese Scientific Journal Database, including studies and published systematic review in the reference list and grey. Three reviewers will search these databases, select data and evaluate the quality of studies separately. The methodological quality will be measured by the Cochrane risk of bias tool. The Review Manager 5.3 will be used to synthesize collected data.Results: The systematic review will evaluate the safety and efficacy based on current evidence of acupuncture for ONP. The primary outcomes are the therapeutic efficiency, the sizes of palpebral fissure and pupil, the range of eye movement and scores of diplopia. Quality of life, and adverse effects will be assessed as secondary outcomes. Conclusion: The study will provide high-quality recently evidence for evaluating the efficacy of acupuncture for patients with ONP. PROSPERO registration number: CRD42020162140.
Malnutrition Affects Cholesterol Paradox in Coronary Artery Disease: a 41,229 Chinese Cohort Study
Authors: Wang Bo , Liu Jin , Chen Shiqun , Ying Ming , Chen Guanzhong , Liu Liwei , Lun Zhubin , Li Huanqiang , Huang Haozhang , Li Qiang , Yu Yaren , Lin Mengfei , Wei Wen , Huang Zhidong , Yang Yongquan , Chen Jiyan , Tan Ning , Liu Yong
Published: February 2021

Background: Several studies found that baseline low LDL-C concentration was associated with poor prognosis in patients with acute coronary syndrome (ACS), which was called “cholesterol paradox”. Low LDL-C concentration may reflect underlying malnutrition, which was strongly associated with increased mortality. We objected to investigate the cholesterol paradox in patients with CAD and the effects of malnutrition.Method: A total of 41,229 CAD patients admitted to Guangdong Provincial People's Hospital in China were included in this study from January 2007 to December 2018, and divided into two groups (LDL-C < 1.8 mmol/L, n=4,863; LDL-C ≥ 1.8 mmol/L, n = 36,366). We used Kaplan-Meier method and Cox regression analyses to assess the association between LDL-C levels and long-term all-cause mortality and the effect of malnutrition. Result: In this real-world cohort (mean age 62.94 years; 74.94% male), there were 5257 incidents of all-cause death during a median follow-up of 5.20 years [Inter-quartile range (IQR): 3.05-7.78 years]. Kaplan–Meier analysis showed that low LDL-C levels were associated with worse prognosis. After adjusting for baseline confounders (e.g., age, sex and comorbidities, etc.), multivariate Cox regression analysis revealed that low LDL-C level (<1.8mmol/L) was not significantly associated with all-cause mortality (adjusted HR, 1.04; 95% CI, 0.96-1.24). After adjustment of nutritional status, risk of all-cause mortality of patients with low LDL-C level decreased (adjusted HR, 0.90; 95% CI, 0.83-0.98). In the final multivariate Cox model, low LDL-C level was related to better prognosis (adjusted HR, 0.91; 95% CI, 0.84-0.99).Conclusion: Our results demonstrate that the cholesterol paradox persisted in CAD patients, but disappeared after accounting for the effects of malnutrition.
The use of A. mellifera drone's olfactory sensitivity towards pathological odours as a selection trait in the breeding against V. destructor
Authors: Ivanova Ivelina , Bienefeld Kaspar
Published: February 2021

The most effective strategy against brood diseases, such as infestation by the mite Varroa destructor, is the early detection and removal of sick brood. Recent findings suggest that genes associated with worker bees' olfactory perception play a central role in Varroa-sensitive hygiene (VSH). In the following approach, Apis mellifera drones' odour sensitivity was examined through a standardised Proboscis extension response (PER) test. Individuals with a positive/negative conditioning outcome to two parasitised-pupae extracts (extract-low and extract-high) were used for breeding. Twenty-one queens from a VSH selection line (SelQ) and nineteen queens from an unselected line (ConQ) were single-drone-inseminated with drones that showed either a positive (SenD+) or a negative (SenD-) PER test. Individual VSH behaviour of a total of 5072 offspring of these combinations (SelQ x SenD+, SelQ + x SenD-, ConQ x SenD+, ConQ x SenD-) was subsequently observed in a specially designed unit with infrared light. The results from the observation were also separately examined, considering the hygienic status of the participating queens and drones. The results of the PER test of the drones were not significantly reflected in the VSH results of the respective offspring. On the other hand, the participating queens/drones' hygienic status was crucial for the manifestation of VSH.
HOXC10 promotes growth and migration of melanoma by regulating Slug to activate the YAP/TAZ signaling pathway
Authors: Miao Yuanxin , Zhang Weina , Liu Su , Leng Xiangfeng , Hu Chunnan , Sun Hao
Published: February 2021

Homeobox C10 (HOXC10) has been reported to participate in various cancers. However, the involvement of HOXC10 in melanoma is still remains unknown. Here, we attempted to determine whether HOXC10 can affect the development of melanoma. We separated melanoma tissues and the matched tumor-adjacent normal tissues from melanoma patients, and examined HOXC10 expression in the melanoma cells and tissues. Comparing with the tumor-adjacent normal tissues, HOXC10 was up-regulated in melanoma tissues. Melanoma cells also displayed an up-regulation of HOXC10. Moreover, HOXC10 overexpression promoted cell proliferation, clone formation and inhibited apoptosis of melanoma cells. HOXC10 up-regulation also enhanced migration, invasion and epithelial-mesenchymal transition (EMT) in melanoma cells. Additionally, HOXC10 accelerated Slug expression by interacting with Slug, and activating the promoter of Slug. Slug activated the YAP/TAZ signaling pathway, which was reversed by HOXC10 silencing. The in vitro assays demonstrated that inhibition of HOXC10 significantly repressed tumor growth and lung metastasis of melanoma in mice by inhibiting Slug and YAP/TAZ signaling pathway. In conclusion, this work demonstrated that HOXC10 promoted growth and migration of melanoma by regulating Slug to activate the YAP/TAZ signaling pathway. Therefore, this study suggests that inhibition of HOXC10 has therapeutic potential in melanoma.
Complex rearrangement in acute myeloid leukemia M2 with RUNX1/RUNX1T1 fusion involving chromosomes 8, 17 and 21
Authors: Mishra Shiba Ranjan , Rawal Leena , Othman Moneeb A.K. , Thatai Atul , Sarkar Aditi , Lal Vandana , Bhattacharya Saurabh Kumar
Published: February 2021

BackgroundThe translocation t(8;21)(q22;q22) is one of the most frequent chromosomal abnormalities associated with acute myeloid leukemia (AML) sub type M2. About 3–5% of cases with additional chromosomal abnormalities, including structural and numerical ones, are reported to include a complex translocation t(8;21;N).Case PresentationHere we report a chromosome rearrangement observed in a 19 years-old female diagnosed with AML-M2. When subjected to (molecular) cytogenetic analyses a complex three-way translocation involving chromosomes 8, 17 and 21 was detected, forming not a t(8;21;17) as one would expect. Real time-polymerase chain reaction analysis using 6 AML specific markers showed the presence of RUNX1/RUNX1T1 fusion gene transcripts identical to those found in classical translocation t(8;21) coupled with presence of FLT3-ITD mutation identified by fragment analysis.ConclusionsThe present case highlights importance of complex rearrangements rarely encountered in AML, suggesting that all involved regions harbor critical candidate genes regulating the pathogenesis of AML, leading to novel as well as well-known leukemia associated chromosomal aberrations.
Dynamic analysis and experiment of QZS system with nonlinear hysteretic damping
Authors: Hu Xiaoying , Zhou Chunyan
Published: February 2021

Nonlinear Quasi-zero-stiffness (QZS) vibration isolation systems with linear damping cannot lead to displacement isolation with different excitation levels. In this study, a QZS system with nonlinear hysteretic damping was investigated. The Duffing-Ueda equation with a coupling nonlinear parameter 𝜂 was proposed to describe the dynamic motion of the QZS system. By using the harmonic balance method (HBM), the primary and secondary harmonic responses were obtained and verified by numerical simulations. The results indicated that nonlinear damping can guarantee a bounded response for different excitation levels. The one-third subharmonic response was found to affect the isolation frequency range even when the primary response was stable. To evaluate the performance of the QZS system, the effective isolation frequency Ω𝑒 and maximum transmissibility 𝑇𝑝 were proposed to represent the vibration isolation range and isolation effect, respectively. By discussing the effect of 𝜂 on Ω𝑒 and 𝑇𝑝, the conditions to avoid nonlinear phenomena and improve the isolation performance are provided. A prototype of the QZS system was then constructed for vibration tests, which verified the theoretical analysis.
Non-integrability of the Kepler and the two body problem on the Heisenberg group
Authors: Maciejewski Andrzej , Stachowiak Tomasz
Published: February 2021

The analog of the Kepler system defined on the Heisenberg group introduced by Montgomery and Shanbrom (2015) is integrable on the zero level of the Hamiltonian. We show that in all other cases the system is not Liouville integrable due to the lack of additional meromorphic first integrals. We prove that the analog of the two body problem on the Heisenberg group is not integrable in the Liouville sense.
Ethnic and Racial Differences in Adoption of Evidence-based Diabetes Prevention Strategies and Weight Loss Outcomes in a Shared Decision-Making Intervention
Authors: Castellon-Lopez Yelba , Duru O. Kenrik , Turk Norman , Moreno Gerardo , Norris Keith , Vu Amanda , Saju Rintu , Tseng Chi Hong , Skrine-Jeffers Kia , Mangione Carol , Frosch Dominick , Moin Tannaz
Published: February 2021

Background: To promote health equity, interventions should achieve similar clinical outcomes among all subgroups. However, evidence from real-world Diabetes Prevention Program (DPP) translation studies suggests that adoption of diabetes prevention strategies and weight loss outcomes may vary by race and ethnicity.Methods: In this retrospective analysis, we examined adoption of diabetes prevention strategies and weight change outcomes among participants who received a shared decision making (SDM) intervention as part of the Prediabetes Informed Decisions and Education (PRIDE) study. We compared (1) uptake of DPP and/or metformin and (2) percent weight change at 12 months stratified by race/ethnicity using generalized linear mixed effects models. Results: SDM participants (n=515) were on average 56 years old (SD=11.0) with HbA1c 6.0% (SD=.20) and BMI of 30.3 (SD=5.2) who self-identified as non-Hispanic White (NHW) (39.2%), non-Hispanic Asian/Pacific Islander (NHAPI) (18.4%), Hispanic (16.7%), or non-Hispanic Black (NHB) (14.4%). There were no significant differences in adoption of DPP and/or metformin between racial/ethnic groups. NHB and Hispanic participants lost significantly less weight at 12 months as compared to NHW participants (-1.0% and -1.2%, respectively, vs. -3.3%, both comparisons p<.01). Conclusion: While adoption of evidence-based options for diabetes prevention did not vary, Hispanics and NHB lost significantly less weight than NHW at 12-months follow-up after SDM. Minority groups have a higher risk of type 2 diabetes and racial/ethnic disparities in weight change outcomes after adoption of diabetes prevention strategies can further compound risk. These findings have important implications for ongoing efforts to augment diabetes prevention and health equity nationally.
Feasibility of a Nutrition and Lifestyle Focused Shared Medical Appointment Program in a Resource-Challenged Community Setting
Authors: Bharmal Nazleen , Beidelschies Michelle , Alejandro-Rodriguez Marilyn , Alejandro Kayla , Guo Ning , Jones Tawny , Bradley Elizabeth
Published: February 2021

Background: In order to address disparities in preventable chronic diseases, we adapted a nutrition and lifestyle focused shared medical appointment (SMA) program to be delivered in an underserved community setting. The objective was to determine the feasibility of the community-based SMA pilot.Methods: The SMA program was a community benefit for community residents regardless of their participation in the research study. We evaluated pre-post changes in wellness indices, biometrics, self-efficacy, and trust in medical researchers. To understand the barriers and facilitators for implementation and scalability, we conducted two participant focus groups and five stakeholder interviews and used content analysis to determine major themes. Key Results: Fifteen participants attended 10 weekly sessions. The majority were older adult, African American women. There were pre-post improvements in mean systolic (-10.5 [7.7] mmHg, p=0.0001) and diastolic (-4.7 [6.7] mmgHg, p=0.17) blood pressures and weight (-5.7 [6.3] pounds, p=0.0034) at 3 months though these were not significant at 6 months. More individuals reported improvements in health status, daily fruit and vegetable intake, and sleep than at baseline. There were no significant pre-post changes in other wellness indices, self-efficacy, trust in medical researchers, hemoglobin A1c, insulin, or LDL cholesterol. Participants discussed positive health changes as a result of the SMA program, program preferences, and facilitators and barriers to continuing program recommendations in focus groups. SMA implementation was facilitated by clinical staff who adjusted content to a low health literacy group and partnership with a trusted community partner. Sustainability barriers include heavy personnel time and in-kind resources to deliver the program. Conclusion: Lifestyle-focused community-based SMAs can be a feasible and acceptable intervention for patients with neighborhood disadvantage, especially in partnership with trusted organizations.
Feminitives in the Ukrainian Language: the Linguistic and Social context
Authors: Stezhko Yuriі
Published: February 2021

The article highlights the problems of new spelling, in particular, the introduction of feminitives, in social and linguistic aspects. The idea is made that the feminitivization of language is a natural consequence of the Ukrainization of all spheres of social life. The relevance of the topic of our research is due to the incompleteness of linguo-social reflection regarding the assessment and boundaries of the use of feminitives. Therefore, the purpose of the article is to research the feminitization of the Ukrainian language in the linguistic and social aspects, the conditionality of the applied form of feminitives by the phonosemantic context and articulatory performance. A retrospection of spelling developments by Ukrainian linguists is carried out in the projection on the modern update of Ukrainian spelling. The social aspect of the introduction of feminitives is revealed as a manifestation of national identity and gender equality. In the linguistic aspect, the feminitivization of the language is the ordering of morphological and syntactic norms of the Ukrainian language, violated by masculinitives (designation of the female sex by male names). It is noted that the formation of feminitives using this or that suffix has a phonosemantic and contextual conditionality. In addition, an indication of the expediency / inexpediency of using one or another suffix when creating a feminitive should be the compatibility of the sounding of adjacent words, their articulatory performance and tolerance in relation to public opinion. In general, the introduction of feminitives, like the new spelling, is assessed as an adequate response to modern public demands.
Specificity of Understanding the Problem of Gender Relations in Jhumpa Lahiri`s Writing
Authors: Yalovenko Olha
Published: February 2021

The article deals with the specificity of understanding the problem of gender relations in Jhumpa Lahiri`s writing (the American writer of Bengali origin). The article`s aim is to explore the peculiarities of gender relations in the context of the transculture paradigm in Jhumpa Lahiri`s writing. Research methods: historical and typological (determining the specifics of themes, motifs, images, story features of the writer`s works), hermeneutic (interpretation of various aspects of the literary text), narratological analysis (specifics` analysis of J. Lahiri`s narrative manner).
It is indicated that the study of gender issues is important in the modern literature discourse. The differences between the adaptation of men and women to the new cultural environment are clearly seen in Jhumpa Lahiri`s writing. Yes, men`s purpose is to realize their “American dream”, as most of them emigrate in search of a better life, scientific and academic goals (an example is the man from the story “Mrs. Sen`s”). Like Bengali families, men have every right to make all the important decisions in the family. The features of Indian women's adaptation to the new culture, which are seen not only in overcoming the language barrier, but are traced in everyday life and in relations with men, are analyzed.
Women have completely different adaptation experiences. The problem of gender relations is traced to the identity crisis of the Indian woman in America, who balances between cultures and lives in two worlds: wants to be American and at the same time not forget her “desh” (literally “homeland” in Bengali).
A stereotyped image of an Indian woman who “sacrifices” herself and remains in despair within the American apartment`s walls is portrayed in Jhumpa Lahiri`s works. Gender specificity is seen in the role of “invisible existence”: heroines are associated with maids who can cook dinner and wash socks only. Women seek refuge in the past and avoid the present.
Unlike men, the assimilation process is much more difficult for women. It is mentioned that J. Lahiri shows the material dependence of women on men. The problem of gender relations that is also associated with the decline of family values, where marriage becomes a temporary matter, is no less important.
Encyclopedia of Genealogical Memory, National Identity and Self-respect
Authors: Serebrianska I.
Published: February 2021

Popovsky A. «A little bit about Ukrainian surnames».
The Cognitive-communicative Dimension of the Reproduction of Cultural Information in Literary Translation
Authors: Liashenko Tetiana
Published: February 2021

The paper highlights the strategies of reproduction of cultural specific information and overcoming cultural differences on the material of German translation. As the methodological basis for defining strategies of reproducing cultural information serves the definition of translation as a unity of process and result, as a cognitive-communicative activity that unfolds in a three-phase process - interpretation of the megaconcept of the original, modeling of the megaconcept of translation, and its implementation at the text level. To outline the integrative conceptual image of the original, the method of field modeling of the concept has been applied. The conceptual, image and value components of the hierarchical structure of a megaconcept of the work have been characterized. The transfer of the conceptual image of the original onto the worldview of the German language revealed the differences and lacunarity of cultural information as well as divergence of its value interpretations. As a result of the study, the foreignization was identified as a global strategy for preserving the cultural component of the original text. On the material stated the problems of translation, connected with reproduction of cultural information were studied. The primary focus is on the reproduction of realia, imagery, dialect, national specifics of emotions and overcoming the temporal distance. The correlation between the use of the local strategies of domestication and estrangement and the nature of cultural information reproduction problems was investigated. The tactics and techniques of translation of culturally specific elements of the text were identified.
Concept «Destiny»: Features of Representation in Polish Lingvoculture
Authors: Lutsenko Valentyna , Lutsenko Olga
Published: February 2021

Concept «los» («destiny») as a key in the Polish culture has many lexical representation. «Destiny» in Polish is the life, the existence of someone or something; future, sequence of events; the supreme regulatory beginning. Destiny is thought of as contradictory, ambivalent beginning. It is able to help or hinder. Carriers of the Polish language are ambivalent in their relation to the destiny. Presence of the destiny may either be approved or denied. Poles have different views on the nature of destiny. On the one hand, destiny is presented as unchangeable and predefined from above. On the other, there is a view that it is created during the life (existence), and, for example, a person can have a significant influence on it. Metaphorically in Polish destiny is represented by the signs of person, connecting or disconnecting, gracious or formidable beginning.
Communicative and Pragmatic Functions of Lexical Blends in Advertising Discourse
Authors: Medvid Olena , Vashyst Kateryna , Solomka Alyona
Published: February 2021

The article examines the communicative and pragmatic functions of lexical blends in advertising discourse. It determines that advertising discourse is an area that actively uses lexical blends due to its accuracy, information compression, and simplicity of formation. The concept of advertising, which is defined as a special type of communication, the purpose of which is to have a communicative impact on a potential consumer, has been clarified.
The article also describes the classification of advertising types according to various criteria. The main goal of advertising is defined, that is, influencing both specific individuals and society as a whole, and the main purpose of an advertising text is determined, that is to attract attention and promote sales of goods and services.
The concept of blending as one of the most productive ways of word formation in the English language (the language of analytical structure) has been clarified. The authors determine that blending represents the great potential for giving the word an expressive and evaluative color compared to other word-formation ways. They consider and describe the potential of blends not only in Germanic (English and German), but also in Slavic (Ukrainian) languages, having the different — synthetic structure. Examples of blends in English, German, and Ukrainian advertising discourse are analyzed.
The research studies the communicative and pragmatic functions that reflect both the speaker's attitude to the content of the message and its recipient. The article defines that the communicativeness of the blend is in its ability to establish contact with the message recipient, and the pragmatic aspect is to convince the consumer to buy the advertised product.
This article provides an up-to-date idea of the communicative and pragmatic functions of blends in English, German and Ukrainian advertising discourse, as these lexical units strive for expressiveness, evaluation, brevity, and help to attract the attention of the reader or listener.
DEL AULA PRESENCIAL A LA REMOTA Y DE REGRESO: LA ENSEÑANZA EN SITUACIONES DE PANDEMIA E INCERTIDUMBRE
Authors: González Fernández Karen
Published: February 2021

La pandemia provocada por el virus del COVID 19 trajo cambios importantes para muchos modelos educativos. La enseñanza presencial se convirtió, de manera brusca e inesperada, en enseñanza en entornos digitales remotos. El objetivo de este artículo es presentar una discusión sobre uno de los mayores retos que los sistemas educativos enfrentan en contextos como el presente: la incertidumbre generada por el cambio de la enseñanza presencial a la enseñanza remota y viceversa. Para lograr el objetivo: 1) muestro de qué manera el cambio de la enseñanza presencial a la remota provoca un problema al nivel de la planeación y el diseño de los cursos, y un reto específico para la labor docente, y 2) ofrezco el esbozo de una propuesta para enfrentar este tipo de situaciones, recurriendo al modelo de diseño instruccional ADDIE y considerando algunas competencias docentes específicas. Finalmente propongo unas reflexiones sobre algunos retos que la pandemia ha generado para la pedagogía en general y los diversos modelos educativos en particular.
Treatment of Catatonia with Asenapine in a Patient with Schizotypal Personality Disorder, Psychotic Depression and Septic Shock from SARSCoV- 2 - A Case Report
Authors: Fiaschè Federica , Adriani Barbara , Mancinelli Iginia , Taranto Aldo
Published: February 2021

Introduction:

Catatonia is a psychomotor syndrome that presents with severe symptoms
which can lead to dangerous and lethal conditions if not diagnosed and treated properly. SARS--
CoV-2 is a positive-sense single-stranded RNA virus that can occur in severe cases with acute
pneumonia, ARDS, sepsis and septic shock. In these cases, ICU admission is necessary.

Case Summary:

A 59-year-old Caucasian man with septic shock and bilateral interstitial pneumonia
from SARS-CoV-2 and schizotypal personality disorder presented with catatonic behaviour
manifested by soporous state, response to intense painful stimuli with the opening of the eyes, execution
of simple verbal commands, maintenance of the same position, catalepsy, immobility, rigidity
and mutism. At the same time, there were symptoms of septic shock and catatonic symptoms,
causing greater difficulty in the correct formulation of the diagnosis. During the course of his hospitalization,
he was treated with asenapine 20 mg/day. The catatonia responded rapidly and significantly
to the asenapine.

Discussion:

To date, the pathophysiology of catatonia is unclear, and few guidelines are available
for the treatment of catatonia. In the literature, studies have reported the efficacy of benzodiazepines
such as lorazepam and diazepam, GABAA agonists such as zolpidem, NMDA receptor antagonists
such as memantine, antidepressant SSRIs such as fluoxetine and paroxetine, and antipsychotics
such as olanzapine, clozapine and aripiprazole. We demonstrate that the antipsychotic asenapine
is also effective in treating catatonic symptoms in psychiatric disorders.

Conclusion:

Asenapine produced a rapid and significant reduction in catatonic symptoms in our patient
with schizotypal personality disorder.
The Impact of Vitiligo on Patients' Psychological Status and Sexual Function: Cross-Sectional Questionnaire-Based Study
Authors: Alhetheli Ghadah I
Published: February 2021

Introduction:

Vitiligo is a chronic pigmentary cutaneous disorder. Although vitiligo is not a life-threatening disease, it seriously affects patients' psychological status and Quality-of-Life (QoL). Moreover, the effect of vitiligo on genital image severely affects sexual function, especially in females.

Patients & Methods:

This cross-sectional questionnaire-based study had targeted patients with vitiligo of both genders. 173 patients who had responded to the given questionnaires were included and their responses were statistically analyzed. Patients’ files were revised for extraction of demographic and clinical data and the previous evaluation of the Vitiligo Area Scoring Index (VASI) score.

Results and Discussion:

Median VIS-22 score was in the range of 21-49, but 109 patients had a median score of 28. Seventy-eight patients had mild and 15 patients had moderate depression. Regression analysis defined the sense of being unattractive, disappointed in self and discouragement about the future as the most significant underlying causes of depression. Ninety-two patients had sexual dysfunction and scoring of satisfaction by the sexual act was the highest while scoring for the desire was the lowest. Regression analysis revealed that female gender, high ASEX and VASI scores are the significant predictors for high BDI-II. ROC curve analysis defined a high ASEX score as a significant predictor for a high BDI-II score.

Conclusion:

The obtained results indicated a deleterious effect of vitiligo on patients’ psychological status that may progress to depression. The effects of the disease on body image, especially the genital area, induced sexual dissatisfaction with an impact on sexual function. Altogether, raise a suggested adjuvant role for psychotherapy in patients with vitiligo which might even indirectly lead to improvement of vitiligo.
Nanofabrication of Iron-Cobalt (FeCo) Alloy by Sol-gel Method
Authors: Farahmandjou Majid , Khalili Parastoo
Published: February 2021

Background and Introduction:

Metal oxides (MOs) have been extensively used in a
large range of engineering and medical applications.

Methods:

FeCo nanoparticles (NPs) were successfully synthesized by the solgel method in the presence
of a powerful reducing agent-sodium borohydride (NaBH4). The structure, morphology, and
optical properties of NPs were analyzed by X-ray diffraction (XRD), field effect scanning electron
microscopy (FESEM), transmission electron microscopy (TEM), and Fourier transform infrared
spectroscopy (FTIR) at room temperature.

Results:

The XRD spectrum showed the body center cubic (BCC) structure of the samples after
heat treatment at 500 °C. The SEM analysis exhibited that the particle size of as-synthesized and annealed
samples was approximately 40 nm and 22 nm, respectively.

Conclusion:

The TEM investigations showed the rod-shaped sample of annealed NPs. The optical
studies of the FTIR analysis revealed the starching bound of Fe-Co at the frequencies of 673 cm-1,
598 cm-1, and 478 cm-1.
SARS-CoV-2: Molecular Biology and Therapeutic Targets
Authors: Pandey Vivek , Pathak Ankita , Yar Mohammad Shahar , Pokharel Yuba Raj
Published: February 2021

A century after the outbreak of the Spanish flu, the world is suffering from another pandemic
because of the coronavirus. The virus took a toll on more than millions of lives worldwide
and continues to affect the health and socio-economic infrastructure all over the world. This study
explores the epidemiology, etiology, and transmission of the virus and its phylogenetic relationship
with SARS and MERS coronavirus responsible for the 2002 and 2012 viral outbreak. Furthermore,
this review highlights the key features of the viral genome and essential viral proteins responsible
for the viral life cycle, evading host immune response, and viral immunopathology with therapeutics
from “Recovery” and “Solidarity” trials. The review culminates with a discussion on different
classes of prominent vaccines and their efficacy. An overall understanding of essential viral proteins
and their role
Peripartum Cardiomyopathy (PPCM): How to Diagnose and Deal with?
Authors: Sitio Monika , Tri Tjahjono Cholid , Martini Heny , Kurnianingsih Novi
Published: February 2021

Peripartum cardiomyopathy (PPCM) is a diagnosis of exclusion, where patients present with heart failure (HF) secondary to left ventricular (LV) systolic dysfunction without any other cause of HF identified in the last month of pregnancy or within first five months after delivery, abortion, or miscarriage. PPCM is a life-threatening condition which frequently under diagnosed and inadequately treated, whereas the morbidity and mortality rate ranges between 7% and 50%. Early diagnosis is important to decrease morbidity and mortality. Therefore, it is necessary to report the case related to this condition. A 34-year-old woman was referred to RSSA with worsening shortness of breath (SOB). She has given birth about 2.5 months prior to admission. History taking and supporting findings form this case were supported to diagnosis of PPCM. She was treated with diuretic, aldosterone antagonist, ACE-I, beta blocker, anticoagulant, and bromocriptine. The symptoms were improved in the following days. She was discharged with better condition and educated to comply with medication.
Pengaruh Berbagai Konsentrasi Giberelin (GA3) terhadap Pertumbuhan dan Hasil Bunga Krisan (Chrysanthemum morifolium L.) di Dataran Medium
Authors: Sembiring Elsi Kris Dayanti , Sulistyaningsih Endang , Shintiavira Herni
Published: February 2021

Tanaman krisan merupakan tanaman sub tropis yang apabila dibudidayakan di daerah tropis seperti Indonesia membutuhkan lingkungan tumbuh yang tepat. Intensitas yang tinggi, suhu udara yang tinggi serta kelembaban yang rendah tentu dapat menurunkan kualitas hasil bunga krisan. Oleh karena itu pemberian giberelin diharapkan mampu memperbaiki kualias hasil bunga krisan potong seperti diameter bunga. Penelitian ini dilakukan untuk menentukan konsentrasi Giberelin (GA3) yang lebih efisien untuk pertumbuhan dan kualitas hasil bunga krisan. Penelitian ini dilakukan di desa Gerbosari, Kecamatan Samigaluh, Kabupaten Kulon Progo, DIY tepatnya 485 m dpl (dataran medium) pada bulan September 2018-Januari 2019. Bahan utama yang digunakan yaitu bunga krisan tipe spray varietas Yastayuki yang ditanam pada rumah plastik dan giberelin. Penelitian ini menggunakan metode Rancangan Acak Kelompok Lengkap (RAKL) dengan empat perlakuan konsentrasi giberelin yang terdiri dari 200 ppm, 400 ppm dan 600 ppm serta aquades sebagai kontrol. Perlakuan giberelin diaplikasikan dengan penyemprotan selama tiga kali berturut- turut, pada umur 8, 9 dan 10 minggu setelah tanam. Pemberian giberelin dengan konsentrasi 400 ppm sudah mampu meningkatkan panjang tangkai bunga dan lama kesegaran bunga (vase life), namun tinggi tanaman dan kelas mutu bunga grade AA terlihat signifikan ketika pemberian giberelin konsentrasi 600 ppm. Pada umur panen bunga, perbedaan yang signifikan telah terlihat pada pemberian konsentrasi terendah yaitu 200 ppm, semakin tinggi konsentrasi giberelin yang diberikan maka semakin cepat umur panen bunga yang dihasilkan.
Pengaruh Konsentrasi Kitosan Udang dan Kepiting sebagai Edible Coating terhadap Mutu dan Daya Simpan Tomat Ceri (Solanum lycopersicum var. Cerasiforme)
Authors: Marganingsih Anggraeni , Putra Eka Tarwaca Susila
Published: February 2021

Cherry tomatoes are one of horticultural comodity which have high prices. Lost of postharvest of cherry tomatoes causing a proper postharvest management. Chitosan is one of method which can be applied and have edible coating character. This study aims to determine better source and optimum concentration of chitosan to mantain quality and make longer shelf life cherry tomatoes fruit. This study held in Sub-Laboratory of Horticulture, Agriculture of Universitas Gadjah Mada on July until August 2019. This study has designed by random group complete design (RCBD) with one factore and three blocks as reiteration. Treatments tested were source and concentration of chitosan. Source of chitosan consists of crab and shrimp with five concentrations which are 1%, 1,5%, 2%, 2,5%, and 3%. Observation were made on several microclimate variables in the laboratory, several variables of fruit quality, and shelf life of cherry tomatoes. Data analyzed by analysis of variance (ANOVA) a 95% confidence level and continued with Honestly Significance Difference (HSD) test if there are significant differences between treatments. The result shows that crab and shrimp application to 3% concentration  have not positive contribution to mantain quality and make longer shelf life cherry tomatoes. Further study is needed with crab and shrimp chitosan coating with more than 3% concentrations.