bluuebunny/crossref_metadata_2025 huggingface dataset:
A coagulopathic conundrum of COVID-19
Authors: Iskander Peter , Zheng Jiayi , Zaidi Syed Muhammad Hussain , Iskander Anthony
Published: March 2023

We present a case of an elderly male who presented to the hospital with a worsening cough and shortness of breath. Previous outpatient COVID-19 polymerase chain reaction test was negative, and the patient’s symptoms failed to improve despite one-week course of antibiotics. He presented to the hospital a few days later with worsening symptoms and a positive COVID-19 polymerase chain reaction test at this time. Patient was febrile, tachycardic, hypertensive, and was admitted to the intensive care unit due to desaturation on room air ultimately leading to intubation. CBC with differential showed evidence of thrombocytopenia, elevated INR/D-Dimer/fibrin split products/inflammatory markers, as well as decreased fibrinogen. He was treated for COVID-19 pneumonia and given platelets/cryoprecipitate/Vit K for suspected diffuse intravascular coagulation.
Recurrent Neck Abscess in a Child: Is Fourth Branchial Arch Anomaly More Common than We Think?
Authors: D’Oliveiro Jo-Lynn Jean , Saniasiaya Jeyasakthy , Kulasegarah Jeyanthi
Published: March 2023

Branchial arch anomalies are the second most common cause of congenital lesions of the head and neck in children. We discuss a case of recurrent neck abscess in a young child, which eventually led to a third/fourth branchial cleft anomaly diagnosis. We aim to share our experience in the management of this patient along with a review of literature focusing on the presentation, diagnostic workup and treatment of third/fourth branchial arch anomaly.
Did Russia Invade International Law in Ukraine
Authors: Mahmutovic Adnan
Published: March 2023

Background: It has been a year since Russia heavily invaded Ukraine, leading to prolonged violence and devastation. Russia had previously disregarded international law by annexing Crimea, violating the principle of the use of force, and breaking numerous treaties that safeguard Ukraine’s sovereignty and territorial integrity. Despite the invasion occurring a year ago, Ukraine remains in a dire situation, with the conflict causing significant harm to its people and infrastructure. This paper aims to examine the legal implications of Russia’s invasion from an international perspective, and to consider the potential repercussions of such actions.
Methods: This research paper analyses the legal implications of the conflict between Russia and Ukraine, focusing on Russia’s invasion and annexation of Crimea. Through the application of legal positivism, which seeks to analyse the law in a way that is objective and value-neutral, the paper argues that Russia’s actions contravene Ukraine’s sovereignty and territorial integrity.
Conclusion and recommendations: The Russian Federation’s invasion of Ukraine and subsequent territorial seizure constitutes a violation of international law. While there are ways to address this violation, the possession of nuclear weapons by a state may make it difficult to take action. The ICC is investigating the situation in Ukraine and can prosecute individuals for international crimes, but national courts also have a crucial role in ensuring justice. Notwithstanding, it is imperative for the international community to unite and condemn aggression against independent nations, with a critical mass of states prepared to take measures to halt or decrease acts of aggression while also providing assistance to victims. It is vital to demonstrate that international law remains valid and binding, and that the illegitimate use of force will never be accepted or even tolerated.
Comparison of Optical Coherence Tomography Biomarkers between Bevacizumab Good Responders and Nonresponders Who were Switched to Dexamethasone Implant in Diabetic Macular Edema
Authors: Lee Jeong Hyun , Shin Joo Young , Ahn Jeeyun
Published: March 2023

Purpose: To compare volumetric optical coherence tomography (OCT) biomarkers in bevacizumab responsive and bevacizumab refractory diabetic macular edema (DME) patients switched to the dexamethasone implant to ultimately identify possible prognostic indicators.Methods: Retrospective analysis of DME patients treated with bevacizumab were done. Patients were divided into those who showed response to bevacizumab (bevacizumab only group) and others who were switched to the dexamethasone implant due to lack of response to bevacizumab (switching group). Volumetric OCT biomarkers such as central macular thickness (CMT), inner and outer cystoid macular edema (CME) volume, serous retinal detachment (SRD) volume, retinal volume (CME + SRD volume) within the 6-mm Early Treatment of Diabetic Retinopathy Study circle were calculated. OCT biomarkers were followed up throughout treatment.Results: Among total of 144 eyes, 113 patients were included in the bevacizumab only group and 31 patients were included in the switching group. Compared to the bevacizumab only group, the switching group showed higher baseline CMT (558.00 ± 209.60 µm vs. 454.96 ± 125.88 µm, p = 0.003), larger inner CME (6.02 ± 1.43 mm3 vs. 5.12 ± 0.87 mm3, p = 0.004) and SRD volume (0.32 ± 0.40 mm3 vs. 0.11 ± 0.09 mm3, p = 0.015) and higher proportion of patients with SRD (58.06% vs. 31.86%, p = 0.008). In the switching group, CMT, inner CME and SRD volume all showed significant reduction after switching to the dexamethasone implant.Conclusions: DME with large SRD and inner nuclear layer edema volume may be more effectively treated with the dexamethasone implant than bevacizumab.
A Case of Auricular Schwannoma After Trauma
Authors: Kim Bo Young , Kim Jung Yeon , Chang Young-Soo
Published: March 2023

Schwannoma is a slowly-growing, benign tumor that originates from the Schwann cell and is rarely found in the auricle. In this article, we describe a 20-year-old male patient with an approximately 2 cm auricular mass located in the antitragus of the left ear. The mass was slowlygrowing following an auricular trauma. The mass was completely removed by local excision and the histopathologic review confirmed the diagnosis as an auricular schwannoma. Characteristic immunohistochemical findings may be helpful in differential diagnosis of other tumors. Herein, we present with a literature review a rare case of auricular schwannoma following a trauma.
A Case of Inferior Turbinate Osteonecrosis Due to Denosumab
Authors: Cho Yongmin , Kim Dongha , Shin Jae-Min , Park Il-Ho
Published: March 2023

In rare cases, antiresoprtive medications for osteoporosis cause osteonecrosis. Necrotic bone lesions localized at the jaw after the use of antiresorptive medications is named medicationrelated osteonecrosis of the jaw (MRONJ). Although some cases with MRONJ affect the paranasal sinus, inferior turbinate necrosis have not been reported in South Korea yet. Here, we report a case of inferior turbinate osteonecrosis that developed after denosumab had been used.
Complicações na descompressão da pulseira hemostática compressiva: uma revisão integrativa
Authors: Lima Itamara Farias de , Calçado Fernanda Jacques , Simonetti Sérgio Henrique
Published: March 2023

Introdução: O cateterismo cardíaco é um exame invasivo com vista ao diagnóstico e/ou intervenção percutânea. A utilização da via radial é de grande interesse por delimitar inúmeras vantagens e custo-efetividade. O uso da pulseira compressiva como método de curativo compressivo vem sendo cada vez mais utilizado devido suas características que possibilitam melhor visualização do sítio de punção, entre outros. Objetivo: Identificar evidências na literatura sobre complicações relacionadas a descompressão da pulseira hemostática compressiva por profissionais que atuam neste cenário específico. Método: Trata-se de uma revisão integrativa, publicados nos idiomas português, espanhol e inglês do período de 2012 a 2022. A busca foi realizada nas seguintes bases de dados: Literatura Latino-Americana e do Caribe em Ciências da Saúde (LILACS), National Library of Medicine USA (MEDLINE) e Scientific Electronic Library On Line (SCIELO) e na biblioteca virtual Banca Virtual de Saúde (BVS) por meio dos operadores booleanos AND, NOT e OR. Resultados: Foram selecionados e analisados 11 artigos relacionados à temática, 54,54% dos artigos evidenciaram que a utilização da pulseira hemostática combinada a um menor tempo de compressão é um método seguro e eficaz. Conclusão: A utilização da pulseira hemostática é uma forma de curativo compressivo seguro. Tal evidência do método diminui complicações relacionadas à via de acesso como oclusão da artéria radial, pequenos sangramentos e hematomas.
Efeito dos inibidores do co-transportador sódio-glicose tipo 2 sobre o desfecho renal: Uma revisão integrativa
Authors: Araújo Cristiene Neta de Sá , Oliveira Letícia Macêdo de , Rodrigues Yasmim Campos , Santos Luciane de Jesus Mendes , Ferreira Rafaella Lopes , Carvalho Willyanna Ravanielly Oliveira de , Jardim Even Kaline Varella
Published: March 2023

A doença renal crônica (DRC) caracteriza-se por lesão renal de forma progressiva com queda na taxa de filtração glomerular por um período maior que três meses. As principais causas de DRC na população brasileira são o diabetes mellitus tipo 2 (DM2) e a hipertensão arterial sistêmica (HAS). A terapia medicamentosa com inibidores do co-transportador sódio-glicose tipo 2 (iSGLT-2), permite controle da perda da função renal e diminuição da necessidade de pacientes precisarem de terapia renal substitutiva como hemodiálise. Objetivo: Compreender os efeitos dos iSGLT-2 na redução do desfecho renal, a fim de conhecer seus benefícios e eventos adversos. Metodologia: Trata-se de uma revisão integrativa da literatura entre os períodos de janeiro de 2017 a janeiro de 2022, nas bases de dados eletrônicas SCIELO, PUBMED e LILACS, incluindo trabalho em língua portuguesa e inglesa. O diagrama de flow foi utilizado como ferramenta de organização e análise dos artigos. Os trabalhos de interesse foram analisados e, em seguida, os resultados com seus respectivos dados bibliográficos foram organizados em um quadro. Resultados: Foram analisados 12 ensaios clínicos randomizados, dos quais 5 (42%) estudos sobre canagliflozina, 4 (33%) estudos sobre a dapagliflozina, 2 (17%) sobre a empagliflozina e apenas 1 (8%) estudo com a ertugliflozina. Conclusão: Os inibidores de SGLT2 são uma nova classe de medicamentos que demonstrou nos diversos estudos, redução de desfechos renais desfavoráveis, com poucos efeitos colaterais, se mostrando uma ferramenta terapêutica importante no tratamento da população de pacientes com doença renal.
Práticas integrativas e complementares no cuidado de trabalhadores de saúde: uma revisão de escopo
Authors: Faria Josiane Aparecida Melo , Toma Tereza Setsuko
Published: March 2023

O estresse é considerado uma epidemia global que atinge mais de 90% da população, com consequências nefastas para a saúde. Os trabalhadores da saúde respondem por boa parte desses casos, o que ficou evidente durante a pandemia de Covid-19. Nesse contexto, o investimento em ações de promoção à saúde do trabalhador, como as Práticas Integrativas e Complementares em Saúde (PICS), tornam-se ferramentas potentes para o cuidado e melhoria da qualidade de vida. Objetivo: Mapear a literatura global sobre o uso das PICS para o cuidado de trabalhadores da saúde. Métodos: Realizou-se uma revisão de escopo, com busca em fontes de informação de literatura científica no período de outubro-novembro de 2021. O processo de seleção dos estudos foi feito por duas revisoras, de modo independente. A extração dos dados foi realizada por uma revisora e checada por outra. Resultados: De 32 estudos incluídos, metade são revisões sistemáticas. A maioria dos estudos foi conduzida em ambientes hospitalares e ambulatórios, com participantes principalmente da enfermagem, sendo a prática de mindfulness a que apresenta evidências mais robustas. Conclusões: Achados mostram que as PICS constituem ferramentas potentes para o cuidado de trabalhadores da saúde. No entanto, para serem efetivas precisam ser compatíveis com as agendas de trabalho.
O modelo TPACK no contexto da formação de professores: uma revisão sistemática de literatura
Authors: Gonçalves Antoniel Borges , Richit Andriceli
Published: March 2023

Objetivo: identificar na literatura científica dos últimos 10 anos (2013-2022) as principais compreensões acerca do modelo TPACK em relação as tecnologias educacionais na formação de professores. Metodologia: trata-se de uma revisão sistemática de literatura (RSL) e, a coleta de dados deu-se em janeiro de 2023, via serviço de busca da Universidade de Lisboa, Portugal, direcionado a meta-base de dados EBSCO Discovery Service (EDS). Utilizou-se duas equações de busca, uma em língua portuguesa e a outra na língua inglesa. Resultados: inicialmente foram identificados 162 estudos, submetidos a análise de consenso de dois experts na área de tecnologias na educação e formação de professores, identificando 9 artigos em conformidade aos critérios de elegibilidade. Quanto a temporalidade das publicações, observou-se um único artigo publicado no ano de 2022, e a maior frequência de publicação foi no período de 2016 a 2022, com sete estudos e o período de 2012 a 2015 com duas publicações. Conclusão: Considerando o processo formativo do professor fortemente tensionado pela necessidade de adotar e integrar as tecnologias digitais nos mais diversos espaços de ensino e aprendizagem, este movimento mostrou-se muito acentuado pela crise pandêmica da COVID-19. A literatura científica analisada aponta para o modelo TPACK como um eixo de ensino que se apropria de conceitos sobre o uso de tecnologias educativas, estruturado sobre conhecimentos recentes no contexto da formação de professores, porém, com lacunas a serem respondidas em investigações futuras.
Caracterização físico-química e botânica do mel de abelhas sem ferrão (Meliponini), de ocorrência no Vale do Taquari – RS, objetivando edição de RTIQ
Authors: Vieira Tatiana Regina , Noguez Caroline Savi , Santos Mauricio Ayres dos , Wagner Saionara Araujo
Published: March 2023

O Rio Grande do Sul não possui um Regulamento Técnico de Identidade e Qualidade (RTIQ) para o mel de Abelhas Sem Ferrão (ASF), assim sendo, a comercialização desse alimento ocorre informalmente e sem inspeção higiênico-sanitária que garanta sua inocuidade alimentar. Sendo assim, o presente estudo teve como objetivo gerar subsídios para a elaboração de um RTIQ para o mel gaúcho de ASF. Para tanto, foi realizada a caracterização físico-química de 24 amostras de mel de ASF, doadas por 9 associados da Associação dos Meliponicultores do Vale do Alto Taquari. As coletas foram realizadas entre os dias 25 de fevereiro a 05 de março de 2018, de acordo com a disponibilidade de mel excedente em cada meliponário. Realizaram-se as análises físico-químicas para os seguintes parâmetros: Acidez, Açúcares Redutores, Hidroximetilfurfural (HMF), Resíduos Minerais, Diastase, Sólidos Insolúveis e Umidade, além da identificação de predominância botânica. Os resultados deste estudo foram comparados com os RTIQ´s de mel de ASF dos estados da BA, AM, PR e SP e com a legislação nacional. Podemos concluir que, em relação aos parâmetros Açúcares Redutores, Umidade, Sólidos Insolúveis, Cinzas e Acidez todos enquadram-se nos regulamentos citados. Enquanto para os parâmetros Diastase e HMF o enquadramento foi parcial. Sendo assim, é possível, guardadas as particularidades de cada região e a diversidade de espécies de ASF, utilizar os RTIQ’s já existentes como parâmetro para a elaboração do documento para o RS.
Pré-Natal Psicológico: Revisão integrativa da literatura
Authors: Brito Neto Cláudio Soares , Martins Josenice Vasconcelos , Maia Rodrigo da Silva
Published: March 2023

O Pré-Natal Psicológico (PNP) é uma estratégia complementar ao modelo de pré-natal tradicional que busca promover a integralidade do cuidado e minimizar os riscos de depressão no pós-parto (DPP). Este artigo tem o objetivo de analisar os dados da produção acadêmica brasileira a respeito do modelo de PNP. O estudo foi realizado por meio de um levantamento bibliográfico pelo método da revisão integrativa da literatura. As buscas por produções científicas foram realizadas até janeiro de 2023, na base de dados da Biblioteca Virtual em Saúde (BVSalud), na base dos Periódicos CAPES e no Google Acadêmico, utilizando o termo “Pré-natal Psicológico” como descritor. Foram encontrados 32 artigos que, após os critérios de seleção, resultaram na análise de 07 estudos. A partir da análise dos artigos, observamos aspectos relacionados ao PNP atuando na prevenção de DPP; suas contribuições à saúde mental das gestantes; os fatores de risco e proteção para DPP e sobre a estrutura do programa. Desse modo, esta revisão integrativa evidencia o potencial preventivo e a importante ferramenta de promoção da saúde que o modelo de PNP propõe, bem como, a centralidade do profissional da psicologia para o sucesso da intervenção.
Automedicação entre profissionais da saúde durante a pandemia da COVID-19
Authors: Luca Marília Mendes de , Venturi Maria Theresa Iorio , Carvalho Beatriz Cortez de , Vitorino Luciano Magalhães , Cortez Paulo José Oliveira
Published: March 2023

Introdução: Estudos têm demonstrado que a automedicação é uma prática comum no Brasil entre os profissionais da saúde devido à uma tendência em evitar a procura por especialistas.  No entanto, poucos estudos avaliaram a automedicação entre esses profissionais durante a pandemia da COVID-19 no Brasil. Objetivo: Analisar a automedicação entre profissionais da saúde durante a pandemia da COVID-19 no Brasil. Métodos: Realizou-se um estudo observacional, transversal com 290 profissionais da área de saúde, que relataram automedicação. Os participantes responderam a um questionário autoaplicável enviado a profissionais de saúde por canais de comunicação online no período entre outubro de 2020 e janeiro de 2021. Resultados: A amostra de 290 profissionais da saúde relataram automedicação durante esse período. Dentre os medicamentos, os mais utilizados, 161, foram analgésicos e anti-inflamatórios, sendo que o motivo de destaque que levou a essa prática é a experiência anterior sobre o sinal/sintoma, majoritariamente cefaleia e enxaqueca, 131 (45,2%). Conclusão: Conclui-se que os profissionais da saúde mantiveram altos níveis de automedicação durante a pandemia da COVID-19, quando comparado com a literatura pré-COVID-19.
Religiosidade de indivíduos hospitalizados com síndrome coronariana aguda em um hospital de urgência e emergência do Acre
Authors: Santiago Mathews Barbosa , Nascimento Thais Oliveira , Amaral Felipe Cordeiro , Campos Sarah Bader , Conceição Matilde da Silva , Souza Christopher Wando da Silva , Maia Jair Alves , Costa Ruth Silva Lima da
Published: March 2023

Objetivou-se avaliar a religiosidade de indivíduos hospitalizados com síndrome coronariana aguda em um hospital de urgência e emergência do Acre. Trata-se de estudo transversal, descritivo e de abordagem quantitativa. A amostra foi composta por 65 indivíduos de ambos os sexos. Para a coleta de dados, utilizou-se a versão em português da escala de religiosidade da Duke (P-DUREL) e um formulário para coleta de dados sociodemográficos. A maioria encontrava-se na faixa etária de 50 a 60 anos 28 (43%), do sexo masculino 50 (70%), da raça/cor da pele parda 42 (65%), com ensino fundamental incompleto 21(32%) e da religião católica 33(51%). Quanto a religiosidade organizacional a maior parte demostrou frequentar a igreja uma vez por semana 18 (28%). Frente a religiosidade não organizacional a maioria evidenciou realizar a atividades religiosas individuais 26(40%). Sobre os índices de religiosidade intrínseca, observou-se que a maioria verbalizou sentir a presença de Deus 56 ( 86%), que as crenças religiosas estão realmente por trás de toda a sua maneira de viver 41 (63%) e que a maioria se esforça muito para viver a religião em todos os aspectos vida 35 (54%). Conclui-se que a religiosidade dos indivíduos hospitalizados com síndrome coronariana aguda foi considerada satisfatória podendo contribuir para desfechos favoráveis em saúde, no entanto no presente estudo a religião/religiosidade não influenciou no risco cardiovascular.
Birleşmiş Milletler Güvenlik Konseyi Kararlarının Filistin-İsrail Barış Sürecine Etkisi
Authors: ÇALIK TOPUZ Zuhal , ARAFAT Mohammad
Published: March 2023

Filistin-İsrail sorunu, Birleşmiş Milletler’de (BM), 1947’den beri, neredeyse kuruluşundan günümüze kadar hem Genel Kurulu’nun hem de Güvenlik Konseyi’nin gündeminin en üst sıralarında yer almıştır. Uluslararası barış ve güvenliğin sağlanmasına ilişkin birincil sorumluluğu olan Güvenlik Konseyi’nin, Filistinİsrail sorununa dahil olması küresel barış ve güvenliğin tesis edilmesi açısından merkezi konumunun bir yansıması niteliğinde olmuştur. Filistin-İsrail sorunu özelinde, 1946-2022 yılları arasında BM Güvenlik Konseyi’nde altmış iki (62) karar kabul edilmiştir. Bu çalışma kapsamında içerik analizi yöntemiyle BM Güvenlik Konseyi kararları analiz edilmiş ve barışa engel teşkil eden sorunlar; 1) Filistinli mülteciler, 2) Yerleşimciler, 3) Kudüs ve 4) Toprak bütünlüğü olmak üzere dört temel başlık altında sentezlenmiştir. Çalışmada Birleşmiş Milletler’in, çatışma çözümündeki rolüne atıfta bulunarak, Filistin-İsrail sorunu üzerindeki etkisine odaklanılmış ve BM’nin, Filistin-İsrail barış sürecinde hala bir etkisinin olup olmadığı ortaya konulmuştur. Bu yönüyle çalışma, güncel uluslararası çatışma tartışmalarına da farklı bir bakış açısı kazandıracağı için önem taşımaktadır.
Yönetim Kurulu Üye Yapısının Şirket Performansıyla İlişkisi: BİST 100’e İlişkin Ampirik Kanıtı
Authors: Savaşkan Elif
Published: March 2023

Rekabetçi küreselleşen bir dünyada şirketlerin maddi ve maddi olmayan kaynaklarını kullanmak için politikalarını esnek ve verimli bir şekilde ayarlamaları gerekmektedir. İyi bir kurumsal yönetim, şirketlerin uzun vadeli büyümesinin temelini oluşturmaktadır. Şirketlerin kurumsal yönetim anlayışını benimsemesi kar maksimizasyonunun artması demektir. Günümüzde yoğun rekabet ortamında şirketlerin uzun vadede faaliyetlerinin sürdürülebilirliği yönetim kurulu üyelerinin esas görevidir. Yapılan bu çalışma, BİST 100 endeksinde olan şirketlerin yönetim kurulu ve bağımsız yönetim kurulu üye sayısını şirket performansı açısından değerlendirmesini amaçlamaktadır. Çalışmanın modelinde finansal performans ölçütleri olan karlılık oranlarından faydalanılmıştır. Çalışmanın metodolojisi, BİST 100 endeksindeki şirketlerin 2010-2021 yıllarına ait verileri Pearson korelasyon ve regresyon analizi ile gerçekleştirilmiştir. Çalışmanın sonuçlarına göre, yönetim kurulu üye yapısının şirket performansına yönelik ilişkisinde aktif karlılık oranı (ROA) ile negatif yönlü ve anlamlı bir ilişkisi; özsermaye karlılığı (ROE) ile ise herhangi bir anlamlı ilişki olmadığı sonucuna ulaşılırken, yönetim kurulu üye yapısının şirket performansına yönelik etkisinde aktif karlılık oranı (ROA) üzerinde negatif yönlü ve anlamlı bir etkisi olduğu; özsermaye karlılığı (ROE) üzerinde ise bir etkisi olmadığı sonucuna varılmıştır.
Integration of ternary I-III-VI quantum dots in light-emitting diodes
Authors: Islas-Rodriguez Nery , Muñoz Raybel , Rodriguez Jose A. , Vazquez-Garcia Rosa A. , Reyes Martin
Published: March 2023

Ternary I-III-VI quantum dots (TQDs) are semiconductor nanomaterials that have been gradually incorporated in the fabrication of light-emitting diodes (LEDs) over the last 10 years due to their physicochemical and photoluminescence properties, such as adequate quantum yield values, tunable wavelength emission, and easy synthesis strategies, but mainly because of their low toxicity that allows them to be excellent candidates to compete with conventional Cd-Pb-based QDs. This review addresses the different strategies to obtain TQDs and how synthesis conditions influence their physicochemical properties, followed by the LEDs parameters achieved using TQDs. The second part of the review summarizes how TQDs are integrated into LEDs and white light-emitting diodes (WLEDs). Furthermore, an insight into the state-of-the-art LEDs development using TQDs, including its advantages and disadvantages and the challenges to overcome, is presented at the end of the review.
Genomic analysis of chromosomal cointegrated blaNDM-1-carrying ICE and blaRSA-1-carrying IME from clinical multidrug resistant Aeromonas caviae
Authors: Luo Xinhua , Yin Zhe , Yu Lianhua , Zhang Jin , Hu Dakang , Xu Mengqiao , Wang Peng , Wang Fengling , Feng Jiao
Published: March 2023

Introduction

The objective of this study is to thoroughly analyze the detailed genomic characteristics of clinical strain 211703 of Aeromonas caviae, which co-carrying blaRSA-1 and blaNDM-1 genes. 211703 was isolated from the patient’s cerebrospinal fluid drainage sample in a Chinese tertiary hospital.

Methods

Carbapenemase NDM was detected by the immunocolloidal gold technique. The MIC values were determined by VITEK2. The whole genome sequence of 211703 was analyzed using phylogenetics, genomic comparison, and extensive dissection.

Results

This study revealed that 211703 only contained a single 4.78 Mb chromosome (61.8% GC content), and no plasmids were discovered in 211703. 15 different types of resistant genes were detected in the genome of 211703, including blaRSA-1 harbored on integrative and mobilizable element (IME) Tn7413a, and blaNDM-1 harbored on integrative and conjugative element (ICE). The ICE and IME were all carried on the chromosome of 211703 (c211703). Detailed comparison of related IMEs/ICEs showed that they shared similar conserved backbone regions, respectively. Comprehensive annotation revealed that blaRSA-1 was carried by the gene cassette of a novel integron In2148 on Tn7413a, and blaNDM-1 was captured by an insertion sequence ISCR14-like on the ICE of 211703. We speculated that mobile genetic elements (MGEs) such as ICE and IME facilitated the spread of resistance genes such as blaRSA-1 and blaNDM-1.

Discussion

In conclusion, this study provides an overall understanding of the genomic characterization of clinically isolated A. caviae 211703, and an in-depth discussion of multiple acquisition methods of drug resistance genes in Aeromonas. To the best of our knowledge, this is the first report of A. caviae carrying blaRSA-1 even both blaRSA-1 and blaNDM-1, and this is the first bacterium carrying blaRSA-1 isolated from the clinical setting.
Elevated albumin corrected anion gap is associated with poor in-hospital prognosis in patients with cardiac arrest: A retrospective study based on MIMIC-IV database
Authors: Hu Beiping , Zhong Lei , Yuan Meng , Min Jie , Ye Lili , Lu Jianhong , Ji Xiaowei
Published: March 2023

Background

Cardiac arrest(CA) is one of the most leading causes of death. Most of the indicators which used to predict the prognosis of patients with CA are not recognized. Previous studies have suggested that albumin corrected anion gap (ACAG) is associated with recovery of spontaneous circulation in patients with CA, but the predictive value of ACAG for prognosis has not been investigated. This study aims to explore the relationship between ACAG and prognosis during hospitalization in patients with CA.

Methods

The baseline data of adult patients with CA hospitalized in the intensive care unit (ICU) from 2008 to 2019 in the American Intensive Care Database (MIMIC-IV, version v2.0) were collected. According to the in-hospital prognosis, patients were divided into survival and non-survival group. Based on the criteria of ACAG level in the previous literature, patients enrolled were divided into normal ACAG (12–20 mmol/L) and high ACAG (>20 mmol/L) group. The basic information of patients during hospitalization were compared and analyzed between the two groups with propensity score matching (PSM). The Kaplan-Meier method was used to compare the cumulative survival rates of normal ACAG and high ACAG groups before and after matching. Restricted cubic spline (RCS) method and multivariate COX proportional hazards regressions were used to analyze whether elevated ACAG was associated with all-cause mortality during hospitalization.

Results

A total of 764 patients were included. A matched cohort (n = 310) was obtained after PSM analysis. The mortality rate before and after matching in the high ACAG group was higher than that in the normal ACAG group (χ2 = 25.798; P < 0.001; χ2 = 6.258; P = 0.012) The Kaplan-Meier survival analysis before and after matching showed that the cumulative survival rate of the high ACAG group was lower (P < 0.05). RCS analysis showed that ACAG had a non-linear relationship with the risk of in-hospital all-cause mortality (χ2 = 6.060, P < 0.001). Multivariate COX regression analysis before and after PSM suggested that elevated ACAG was an independent risk factor for all-cause mortality in patients with CA during hospitalization (P < 0.01).

Conclusions

Elevated ACAG is associated with increased all-cause mortality in patients with CA during hospitalization, it can be an independent risk factor for poor prognosis in patients with CA and remind clinicians to pay more attention to these patients.
Protection of diabetes in aortic abdominal aneurysm: Are antidiabetics the real effectors?
Authors: Picatoste Belén , Cerro-Pardo Isabel , Blanco-Colio Luis M. , Martín-Ventura Jose L.
Published: March 2023

Aortic aneurysms, including abdominal aortic aneurysms (AAAs), is the second most prevalent aortic disease and represents an important cause of death worldwide. AAA is a permanent dilation of the aorta on its infrarenal portion, pathologically associated with oxidative stress, proteolysis, vascular smooth muscle cell loss, immune-inflammation, and extracellular matrix remodeling and degradation. Most epidemiological studies have shown a potential protective role of diabetes mellitus (DM) on the prevalence and incidence of AAA. The effect of DM on AAA might be explained mainly by two factors: hyperglycemia [or other DM-related factors such as insulin resistance (IR)] and/or by the effect of prescribed DM drugs, which may have a direct or indirect effect on the formation and progression of AAAs. However, recent studies further support that the protective role of DM in AAA may be attributable to antidiabetic therapies (i.e.: metformin or SGLT-2 inhibitors). This review summarizes current literature on the relationship between DM and the incidence, progression, and rupture of AAAs, and discusses the potential cellular and molecular pathways that may be involved in its vascular effects. Besides, we provide a summary of current antidiabetic therapies which use could be beneficial for AAA.
Prediction models for cardiovascular disease risk among people living with HIV: A systematic review and meta-analysis
Authors: Yu Junwen , Liu Xiaoning , Zhu Zheng , Yang Zhongfang , He Jiamin , Zhang Lin , Lu Hongzhou
Published: March 2023

Background

HIV continues to be a major global health issue. The relative risk of cardiovascular disease (CVD) among people living with HIV (PLWH) was 2.16 compared to non-HIV-infections. The prediction of CVD is becoming an important issue in current HIV management. However, there is no consensus on optional CVD risk models for PLWH. Therefore, we aimed to systematically summarize and compare prediction models for CVD risk among PLWH.

Methods

Longitudinal studies that developed or validated prediction models for CVD risk among PLWH were systematically searched. Five databases were searched up to January 2022. The quality of the included articles was evaluated by using the Prediction model Risk Of Bias ASsessment Tool (PROBAST). We applied meta-analysis to pool the logit-transformed C-statistics for discrimination performance.

Results

Thirteen articles describing 17 models were included. All the included studies had a high risk of bias. In the meta-analysis, the pooled estimated C-statistic was 0.76 (95% CI: 0.72–0.81, I2 = 84.8%) for the Data collection on Adverse Effects of Anti-HIV Drugs Study risk equation (D:A:D) (2010), 0.75 (95% CI: 0.70–0.79, I2 = 82.4%) for the D:A:D (2010) 10-year risk version, 0.77 (95% CI: 0.74–0.80, I2 = 82.2%) for the full D:A:D (2016) model, 0.74 (95% CI: 0.68–0.79, I2 = 86.2%) for the reduced D:A:D (2016) model, 0.71 (95% CI: 0.61–0.79, I2 = 87.9%) for the Framingham Risk Score (FRS) for coronary heart disease (CHD) (1998), 0.74 (95% CI: 0.70–0.78, I2 = 87.8%) for the FRS CVD model (2008), 0.72 (95% CI: 0.67–0.76, I2 = 75.0%) for the pooled cohort equations of the American Heart Society/ American score (PCE), and 0.67 (95% CI: 0.56–0.77, I2 = 51.3%) for the Systematic COronary Risk Evaluation (SCORE). In the subgroup analysis, the discrimination of PCE was significantly better in the group aged ≤40 years than in the group aged 40–45 years (P = 0.024) and the group aged ≥45 years (P = 0.010). No models were developed or validated in Sub-Saharan Africa and the Asia region.

Conclusions

The full D:A:D (2016) model performed the best in terms of discrimination, followed by the D:A:D (2010) and PCE. However, there were no significant differences between any of the model pairings. Specific CVD risk models for older PLWH and for PLWH in Sub-Saharan Africa and the Asia region should be established.

Systematic Review Registration: PROSPERO CRD42022322024.
Medical device regulation (MDR) from a dental perspective
Authors: Mohn Dirk , Zehnder Matthias
Published: March 2023

A new regulation for the marketing and application of medical devices has become applicable in the European Union as of May 2021. This regulation is termed EU 2017/745 or Medical Device Regulation (MDR). Initially published and entered into force in 2017, it replaces the former Medical Device Directive 93/42/EEC (MDD), but is still under amendment. The implication of this legislation have broad effects on manufacturers, importers, distributors, users of medical devices, and patients. This article discusses the MDR from the dental perspective. As is illuminated in this text, the MDR will create more red tape for industrial players to get their products CE (Conformitée Européenne) marked, and more documentation work for dentists. This also means that smaller companies acting out of Europe are affected in a disproportionally negative manner compared to their globally acting counterparts. The MDR could and most probably will result in a considerable reduction and price increase of the products that are available to European dentists. Moreover, the MDR could create a rift between dental materials scientists working at universities and the dental industry, because the latter now has to direct more money towards regulatory affairs rather than product development or innovation. On the other hand, the MDR may also act as an antetype for similar regulations in other parts of the world, and could offer new career opportunities for individuals in dental materials research, especially in the regulatory field.
A parallel numerical algorithm by combining MPI and OpenMP programming models with applications in gravity field recovery
Authors: Lu Biao , Luo Zhicai , Zhong Bo , Zhou Hao
Published: March 2023

Satellite gravimetry missions have enabled the calculation of high-accuracy and high-resolution Earth gravity field models from satellite-to-satellite tracking data and gravitational gradients. However, calculating high maximum degree/order (e.g., 240 or even higher) gravity field models using the least squares method is time-consuming due to the vast amount of gravimetry observations. To improve calculation efficiency, a parallel algorithm has been developed by combining Message Passing Interface (MPI) and Open Multi-Processing (OpenMP) programming models to calculate and invert normal equations for the Earth gravity field recovery. The symmetrical feature of normal equations has been implemented to speed up the calculation progress and reduce computation time. For example, the computation time to generate the normal equation of an IGGT_R1 test version of degree/order 240 was reduced from 88 h to 27 h by considering the symmetrical feature. Here, the calculation was based on the high-performance computing cluster with 108 cores in the School of Geodesy and Geomatics, at Wuhan University. Additionally, the MPI parallel Gaussian-Jordan elimination method was modified to invert normal equation matrices and scaled up to 100 processor cores in this study while the traditional method was limited in a certain number of processors. Furthermore, the Cholesky decomposition from the ScaLAPACK library was used to compare with the parallel Gauss-Jordan elimination method. The numerical algorithm has effectively reduced the amount of calculation and sped up the calculation progress, and has been successfully implemented in applications such as building the gravity field models IGGT_R1 and IGGT_R1C.
A rockburst grade evaluation method based on principal component analysis and the catastrophe progression method
Authors: Lou Ying-hao , Li Ke-gang
Published: March 2023

Rockburst disasters always have a great influence on engineering practice. In order to accurately predict the occurrence of rockburst hazards, this paper proposes a rockburst rating evaluation method based on principal component analysis (PCA) and the catastrophe progression method, taking into account several influencing factors. In this paper, 15 indicators, such as strength brittleness factor (R), stress factor (P), and rock quality index (RQD) (reflecting the strength and fragmentation degree of rock mass), were selected from seven samples and were analyzed and downscaled by principal component analysis. Combined with the catastrophe progression method, each layer index was dimensionless and normalized to determine the mutation level value of each layer. Based on the principle of complementarity or non-complementarity, to determine the total mutation level value, the layer index was used to divide the rockblast-level interval and predict the rockblast level. The results show that the method proposed in this paper can be used to not only distinguish the importance of each of the same level of indicators but also avoid the impact of superimposed factor correlations between the same level of indicators, making the results more objective. This paper presents accurate rock explosion assessment results and an actual engineering situation. The number of factors affecting the assessment of the rock explosion level provides new insights.
Education quality and student satisfaction nexus using instructional material, support, classroom facilities, equipment and growth: Higher education perspective of Pakistan
Authors: Ikram Maryam , Kenayathulla Husaina Banu
Published: March 2023

Purpose

The primary purpose is to examine the impact between education quality (EQ) and student satisfaction (SS) in terms of instructional materials, support, classroom facilities and equipment, and growth in Pakistani private higher education institutes.

Design/methodology/approach

This study utilized correlation-focused quantitative research by randomly distributing a 54-item questionnaire to 440 postgraduate students in Pakistan’s private higher education institutions (HEIs). SPSS (V.23) and PLS-SEM (V.3.3.3) were employed to investigate the data.

Findings

The findings demonstrate that EQ has a direct and significant positive effect on student satisfaction with instructional materials, support, classroom facilities and equipment, and growth in private higher education institutions.

Research implications

The current study will help policymakers, the Higher Education Commission (HEC), and institutions to pay greater attention to the significance of education quality indicators in making a difference in higher education, which may contribute to student satisfaction. In addition, their efforts will significantly contribute to the nation’s progress. Furthermore, it will contribute to the betterment of the world by accomplishing the sustainable development goal of quality education set by the United Nations. The recent findings will also have far-reaching advantages for society, demonstrating the positive effects that high-quality education may have on a nation’s progress by creating competent and productive students.

Limitations

Only private universities in Pakistan’s higher education sector were considered for this study, and students enrolled in post-graduate degrees were the subjects of this investigation. This study was restricted to testing in only one province, Punjab, Pakistan. Another limitation of this study is that it is based on a research framework deduced from previous underpinnings and literature.

Originality

These findings contribute to the existing area of research on the direct and significant effects of EQ on SS in HEIs. These findings may positively impact student satisfaction in private higher education institutions. The findings can guide higher education institutions (HEIs) regarding the importance of EQ in achieving desirable student satisfaction (SS). Because the Higher Education Commission (HEC) efforts will contribute considerably to the growth of higher education institutions (HEIs) and the nation, this study is vital for policymakers and practitioners working in higher education.
Non-linear association of fasting C-peptide and uric acid levels with renal dysfunction based on restricted cubic spline in patients with type 2 diabetes: A real-world study
Authors: Chen Lu , Hu Yifei , Ma Yongjun , Wang Huabin
Published: March 2023

Background

Previous studies had showed divergent findings on the associations of C-peptide and/or uric acid (UA) with renal dysfunction odds in patients with type 2 diabetes mellitus (T2DM). We hypothesized that there were non-linear relationships between C-peptide, UA and renal dysfunction odds. This study aimed to further investigate the relationships of different stratification of C-peptide and UA with renal dysfunction in patients with T2DM.

Method

We conducted a cross-sectional real-world observational study of 411 patients with T2DM. The levels of fasting C-peptide, 2h postprandial C-peptide, the ratio of fasting C-peptide to 2h postprandial C-peptide (C0/C2 ratio), UA and other characteristics were recorded. Restricted cubic spline (RCS) curves was performed to evaluated the associations of stratified C-peptide and UA with renal dysfunction odds.

Results

Fasting C-peptide, C0/C2 ratio and UA were independently and significantly associated with renal dysfunction in patients with T2DM as assessed by multivariate analyses (p < 0.05). In especial, non-linear relationships with threshold effects were observed among fasting C-peptide, UA and renal dysfunction according to RCS analyses. Compared with patients with 0.28 ≤ fasting C-peptide ≤ 0.56 nmol/L, patients with fasting C-peptide < 0.28 nmol/L (OR = 1.38, p = 0.246) or fasting C-peptide > 0.56 nmol/L (OR = 1.85, p = 0.021) had relatively higher renal dysfunction odds after adjusting for confounding factors. Similarly, compared with patients with 276 ≤ UA ≤ 409 μmol/L, patients with UA < 276 μmol/L (OR = 1.32, p = 0.262) or UA > 409 μmol/L (OR = 6.24, p < 0.001) had relatively higher odds of renal dysfunction.

Conclusion

The renal dysfunction odds in patients with T2DM was non-linearly associated with the levels of serum fasting C-peptide and UA. Fasting C-peptide and UA might have the potential role in odds stratification of renal dysfunction.
Ovarian dysfunction in women with Turner syndrome
Authors: Fukami Maki
Published: March 2023

Ovarian dysfunction is one of the most common features of women with Turner syndrome. In these women, oocyte apoptosis is markedly accelerated from the early stage of fetal life. Reduction in the number of germ cells disturbs primordial follicle development and thereby leads to the formation of streak gonads. There are three possible causes of accelerated germ cell loss in 45,X ovaries. First, chromosomal pairing failure due to X chromosomal aneuploidy is believed to induce meiotic arrest. Indeed, it has been suggested that the dosage of the X chromosome is more critical for the survival of the oocytes than for other cells in the ovary. Second, impaired coupling between oocytes and granulosa cells may also contribute to germ cell apoptosis. Previous studies have shown that 45,X ovaries may tend to lose tight junctions which are essential for intercellular interactions. Lastly, ovarian dysfunction in women with Turner syndrome is partly attributable to the reduced dosage of several genes on the X chromosome. Specifically, BMP15, PGRMC1, and some other genes on the X chromosome have been implicated in ovarian function. Further studies on the mechanisms of ovarian dysfunction are necessary to improve the reproductive outcomes of women with Turner syndrome.
Vertical distribution differences of the understory herbs and their driving factors on shady and sunny slopes in high altitude mountainous areas
Authors: Han Jiahua , Yin Huiyan , Xue Jie , Zhang Zhiwei , Xing Zhen , Wang Shunke , Chang Jingjing , Chen Xiaoqiang , Yu Bo
Published: March 2023

The vertical distribution understanding of undergrowth herbaceous plants in high altitude mountain areas is of great significance to reveal the environmental gradient change law of plant diversity. However, the species composition of herbaceous plants at different altitude gradients and the relationship between diversity and environmental factors is still vague. This study takes the Sejila Mountain in southeast Tibet at an altitude of 2,000–3,300 m as the study area to analyze the vertical distribution differences of the understory herbs and their driving factors on shady and sunny slopes. The results showed that: (1) The number of families, genera and species of herbaceous plants on sunny slope is greater than that on shady slope. Asteraceae on shady and sunny slopes has the largest number of species; (2) The α diversity index of the herbs on shady slope shows a U-shaped trend. The Cody heterogeneity index (βC) is negatively correlated with the β diversity index. The herb richness index (R) on sunny slope is unimodal. The β diversity index displays the same as that of shady slope; (3) Different environmental factors have different effects on herb diversity. The correlation between environmental factors and diversity indicators indicates that there is a certain degree of clustering among samples. The environmental factors of shady slope and sunny slope are separated; and (4) The difference of water and heat conditions caused by altitude and slope aspect is an important driving factor for the diversity of herbage species, followed by soil clay content, silt content and slope gradient. This study will help to understand the species diversity and ecosystem characteristics of the region, and provide a reference for the study of plant community structure and function and rational utilization of understory plant resources in high-altitude mountain areas.
Novel AGL variants in a patient with glycogen storage disease type IIIb and pulmonary hypertension caused by pulmonary veno-occlusive disease: A case report
Authors: Shindo Akito , Ueda Kazutaka , Minatsuki Shun , Nakayama Yukiteru , Hatsuse Satoshi , Fujita Kanna , Nomura Seitaro , Hatano Masaru , Takeda Norifumi , Akazawa Hiroshi , Komuro Issei
Published: March 2023

Glycogen storage disease type III (GSD-III) is an autosomal recessive metabolic disorder caused by mutations in the AGL gene, and may develop various types of pulmonary hypertension (PH). Here, we report a case of 24-year-old man with GSD-IIIb with two novel null variants in AGL (c.2308 + 2T>C and c.3045_3048dupTACC). He developed multi-drug-resistant pulmonary veno-occlusive disease (PVOD) and was registered as a candidate for lung transplantation. No pathogenic variants were detected in previously known causative genes for pulmonary hypertension and the underlying mechanism of coincidence of two rare diseases was unknown. We discuss the association of the loss of glycogen-debranching enzyme with incident PVOD.