bluuebunny/crossref_metadata_2025 huggingface dataset:
Particulate matter may have a limited influence on maternal vitamin D levels
Authors: Li Chong , Gong Ya-qin , Xia Yun-yu , Wang Xiao-chun , Chen Lin , Yan Shan-jun , Lu Rong-zhu , Lu Ke
Published: October 2022

Evidence for an association between the amount of particulate matter (PM) in the atmosphere and vitamin D status of pregnant women is limited. We aimed to examine the independent association between PM and maternal levels of serum 25-hydroxyvitamin D (25OHD) during the second trimester and to explore possible modifications to the association by meteorological factors. 27,768 pregnant women presenting for prenatal examination who were tested for serum 25OHD concentration during the second trimester between January 1, 2016, and December 31, 2020, were included in this retrospective analysis. Exposure to PM was evaluated based on daily average PM with an aerodynamic diameter of ≤ 2.5 μm (PM2.5) and PM with an aerodynamic diameter of ≤ 10 μm (PM10). Corresponding meteorological data for daily average atmospheric temperature, atmospheric pressure, relative humidity, sunshine duration, and wind speed were collected. The maximum cumulative effects of PM2.5 occurred at lag 45 days, and the maximum cumulative effects of PM10 occurred at lag 60 days. In crude models, 45-day moving daily average PM2.5 concentrations were negatively associated with 25OHD levels (β, − 0.20; 95% CI − 0.21 to − 0.19), as were 60-day moving daily average PM10 concentrations (β, − 0.14; 95% CI − 0.15 to − 0.14). After adjusting for temporal and meteorological factors, the effect values were drastically reduced (adjusted β of PM2.5, − 0.032; 95% CI − 0.046 to − 0.018; adjusted β of PM10, − 0.039; 95% CI − 0.049 to − 0.028). Our study showed there was a small, independent, negative association between PM in the atmosphere and maternal serum 25OHD levels during the second trimester of pregnancy after adjusting for temporal and/or meteorological factors, which indicates that PM may have a limited influence on maternal serum 25OHD levels. Besides taking vitamin D supplements, pregnant women should keep participating in outdoor activities while taking PM protection measures to improve their vitamin D levels when PM levels are high in winter and spring.
Combined transcriptome and metabolite profiling analyses provide insights into the chronic toxicity of carbaryl and acetamiprid to Apis mellifera larvae
Authors: Gao Jing , Yang Yang , Ma Shilong , Liu Feng , Wang Qiang , Wang Xing , Wu Yanyan , Zhang Li , Liu Yongjun , Diao Qingyun , Dai Pingli
Published: October 2022

Despite many studies have revealed that developing honey bee (Apis mellifera) larvae are posting a high risk on exposure to insecticides, the toxicology information on bee larvae remain limited. The present study demonstrated the first assessment of the effects of no observed adverse effect concentration (NOAEC) of carbaryl (CR) and acetamiprid (ACE) on transcriptome and metabolome in honeybee larvae reared in vitro. Chronic exposure to carbaryl caused transcriptional disorders associated with oxidative stress. In addition, a series of metabolic homeostasis were disrupted by carbaryl stress, such amino acid metabolism, purine and pyrimidine metabolism and flavone and flavonol biosynthesis. The activities of enzymic biomarkers including GST, P450, CAT, AChE and SOD were not influenced by ACE stress, while the CR exposure slightly decreased the activity of CAT and SOD. Our results clearly show that ACE and CR display different potential to modulate transcriptome and metabolome associated with their different toxicity against bee larvae.
Facial EMG sensing for monitoring affect using a wearable device
Authors: Gjoreski Martin , Kiprijanovska Ivana , Stankoski Simon , Mavridou Ifigeneia , Broulidakis M. John , Gjoreski Hristijan , Nduka Charles
Published: October 2022

Using a novel wearable surface electromyography (sEMG), we investigated induced affective states by measuring the activation of facial muscles traditionally associated withpositive(left/right orbicularis and left/right zygomaticus) andnegativeexpressions (the corrugator muscle). In a sample of 38 participants that watched 25 affective videos in a virtual reality environment, we found that each of the three variables examined—subjective valence, subjective arousal, and objective valence measured via the validated video types (positive, neutral, and negative)—sEMG amplitude varied significantly depending on video content. sEMG aptitude from “positive muscles” increased when participants were exposed topositively valenced stimulicompared withstimuli that was negatively valenced. In contrast, activation of “negative muscles” was elevated following exposure tonegatively valenced stimulicompared with positively valenced stimuli. High arousal videos increased muscle activations compared to low arousal videos in all the measured muscles except the corrugator muscle. In line with previous research, the relationship betweensEMG amplitudeas a function of subjective valence was V-shaped.
A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses
Authors: Gross Sean M. , Dane Mark A. , Smith Rebecca L. , Devlin Kaylyn L. , McLean Ian C. , Derrick Daniel S. , Mills Caitlin E. , Subramanian Kartik , London Alexandra B. , Torre Denis , Evangelista John Erol , Clarke Daniel J. B. , Xie Zhuorui , Erdem Cemal , Lyons Nicholas , Natoli Ted , Pessa Sarah , Lu Xiaodong , Mullahoo James , Li Jonathan , Adam Miriam , Wassie Brook , Liu Moqing , Kilburn David F. , Liby Tiera A. , Bucher Elmar , Sanchez-Aguila Crystal , Daily Kenneth , Omberg Larsson , Wang Yunguan , Jacobson Connor , Yapp Clarence , Chung Mirra , Vidovic Dusica , Lu Yiling , Schurer Stephan , Lee Albert , Pillai Ajay , Subramanian Aravind , Papanastasiou Malvina , Fraenkel Ernest , Feiler Heidi S. , Mills Gordon B. , Jaffe Jake D. , Ma’ayan Avi , Birtwistle Marc R. , Sorger Peter K. , Korkola James E. , Gray Joe W. , Heiser Laura M.
Published: October 2022

The phenotype of a cell and its underlying molecular state is strongly influenced by extracellular signals, including growth factors, hormones, and extracellular matrix proteins. While these signals are normally tightly controlled, their dysregulation leads to phenotypic and molecular states associated with diverse diseases. To develop a detailed understanding of the linkage between molecular and phenotypic changes, we generated a comprehensive dataset that catalogs the transcriptional, proteomic, epigenomic and phenotypic responses of MCF10A mammary epithelial cells after exposure to the ligands EGF, HGF, OSM, IFNG, TGFB and BMP2. Systematic assessment of the molecular and cellular phenotypes induced by these ligands comprise the LINCS Microenvironment (ME) perturbation dataset, which has been curated and made publicly available for community-wide analysis and development of novel computational methods (synapse.org/LINCS_MCF10A). In illustrative analyses, we demonstrate how this dataset can be used to discover functionally related molecular features linked to specific cellular phenotypes. Beyond these analyses, this dataset will serve as a resource for the broader scientific community to mine for biological insights, to compare signals carried across distinct molecular modalities, and to develop new computational methods for integrative data analysis.
Multivalent binding kinetics resolved by fluorescence proximity sensing
Authors: Schulte Clemens , Soldà Alice , Spänig Sebastian , Adams Nathan , Bekić Ivana , Streicher Werner , Heider Dominik , Strasser Ralf , Maric Hans Michael
Published: October 2022

Multivalent protein interactors are an attractive modality for probing protein function and exploring novel pharmaceutical strategies. The throughput and precision of state-of-the-art methodologies and workflows for the effective development of multivalent binders is currently limited by surface immobilization, fluorescent labelling and sample consumption. Using the gephyrin protein, the master regulator of the inhibitory synapse, as benchmark, we exemplify the application of Fluorescence proximity sensing (FPS) for the systematic kinetic and thermodynamic optimization of multivalent peptide architectures. High throughput synthesis of +100 peptides with varying combinatorial dimeric, tetrameric, and octameric architectures combined with direct FPS measurements resolved on-rates, off-rates, and dissociation constants with high accuracy and low sample consumption compared to three complementary technologies. The dataset and its machine learning-based analysis deciphered the relationship of specific architectural features and binding kinetics and thereby identified binders with unprecedented protein inhibition capacity; thus, highlighting the value of FPS for the rational engineering of multivalent inhibitors.
Rapid quantification of miRNAs using dynamic FRET-FISH
Authors: Kim Juyoung , Kang Chanshin , Shin Soochul , Hohng Sungchul
Published: October 2022

MicroRNAs (miRNAs) are short regulatory RNAs that control gene expression at the post-transcriptional level. Various miRNAs playing important roles in cancer development are emerging as promising diagnostic biomarkers for early cancer detection. Accurate miRNA detection, however, remains challenging because they are small and highly homologous. Recently developed miRNA detection techniques based on single-molecule imaging enabled highly specific miRNA quantification without amplification, but the time required for these techniques to detect a single miRNA was larger than 10 minutes, making rapid profiling of numerous miRNAs impractical. Here we report a rapid miRNA detection technique, dynamic FRET-FISH, in which single-molecule imaging at high probe concentrations and thus high-speed miRNA detection is possible. Dynamic FRET-FISH can detect miRNAs in 10 s at 1.2 μM probe concentration while maintaining the high-specificity of single-nucleotide discrimination. We expect dynamic FRET-FISH will be utilized for early detection of cancers by profiling hundreds of cancer biomarkers in an hour.
Opposing comparable large effects of fine aerosols and coarse sea spray on marine warm clouds
Authors: Liu Fan , Mao Feiyue , Rosenfeld Daniel , Pan Zengxin , Zang Lin , Zhu Yannian , Yin Jianhua , Gong Wei
Published: October 2022

Fine aerosols, by acting as cloud condensation nuclei, suppress rainfall and enhance the albedo and coverage of marine warm clouds, thereby partly counteracting the greenhouse-induced warming. While this is relatively well documented, the co-existing opposite effects of giant cloud condensation nuclei from coarse sea spray aerosols are poorly quantified. Here, satellite measurements show that the effects of coarse sea spray aerosols have comparable magnitudes with opposite sign to those of fine aerosols. For fixed cloud liquid water path and coarse sea spray aerosols, increasing fine aerosols decreased rainfall flux and cloud drop effective radius by a factor of 1/4 and 40%, respectively. Conversely, for fixed fine aerosols and cloud liquid water path, added coarse sea spray aerosols enhanced rainfall flux and cloud drop effective radius by a factor of 4 and 35%, respectively. These large and contrasting effects are independent on meteorological conditions. These processes must be fully incorporated into climate models to faithfully represent aerosol effects on clouds, precipitation, and radiative forcing.
Ecosystem productivity has a stronger influence than soil age on surface soil carbon storage across global biomes
Authors: Plaza César , García-Palacios Pablo , Berhe Asmeret Asefaw , Barquero Jesús , Bastida Felipe , Png G. Kenny , Rey Ana , Bardgett Richard D. , Delgado-Baquerizo Manuel
Published: October 2022

Interactions between soil organic matter and minerals largely govern the carbon sequestration capacity of soils. Yet, variations in the proportions of free light (unprotected) and mineral-associated (protected) carbon as soil develops in contrasting ecosystems are poorly constrained. Here, we studied 16 long-term chronosequences from six continents and found that the ecosystem type is more important than soil age (centuries to millennia) in explaining the proportion of unprotected and mineral-associated carbon fractions in surface soils across global biomes. Soil carbon pools in highly productive tropical and temperate forests were dominated by the unprotected carbon fraction and were highly vulnerable to reductions in ecosystem productivity and warming. Conversely, soil carbon in low productivity, drier and colder ecosystems was dominated by mineral-protected carbon, and was less responsive to warming. Our findings emphasize the importance of conserving ecosystem productivity to protect carbon stored in surface soils.
Self-assembled DNA dendrons as signal amplifiers in a DNA probe-based chemiluminescence assay for enhanced colorimetric detection of short target cDNA
Authors: Do Ji Yoon , Jeong Ji Yun , Lee Chan Yeol , Lee Yun Jin , Hong Cheol Am
Published: October 2022

DNA dendrons are used as signal amplifiers to increase the colorimetric detection of short target cDNA.
Construction of a polyoxometalate-based magnetic composite MOF for the effective adsorption of cationic dyes
Authors: Gao Qiao , Zhao Yu , Gong Jiyu , Chen Xin , Liu Wei , Gao Wenyi
Published: October 2022

Adsorption and separation of dyes are extremely important as they damage the water environment and human health.
A ROS-responsive biomimetic nano-platform for enhanced chemo-photodynamic-immunotherapy efficacy
Authors: Yan Huixian , Zhang Yanan , Zhang Yu , Li Yingying , Kong Xinru , Liu Dongzhu , Li Jin , Xi Yanwei , Ji Jianbo , Ye Lei , Zhai Guangxi
Published: October 2022

Due to the complex bloodstream components, tumor microenvironment and tumor heterogeneity, traditional nanoparticles have a limited effect (low drug delivery efficiency and poor penetration to the deeper tumor) on eradicating tumors.
Recent research progress in galactose-based fluorescent probes for detection of biomarkers of liver diseases
Authors: Deng Xiaojing , Wu Yingxu , Xu Hu , Yan Jiawei , Liu Huanying , Zhang Boyu
Published: October 2022

This highlight illustrates the challenges and latest progress in galactose-based fluorescent probes for early diagnosis of liver diseases.
One-pot heteroannulation toward phosphaperylene diimides with high luminescence and out-of-plane anisotropy
Authors: Ma Zetong , Liu Yujian , Wang Zhaohui , Jiang Wei
Published: October 2022

This work presents a P-heteroannulation strategy on perylene diimides in one pot. The resulting phosphaperylene diimides demonstrate an out-of-plane dipole moment of 8.10 D and high fluorescence quantum yields of up to 94%.
Plasmon-controlled shaping of gold nanostar photothermal therapy agents
Authors: Siegel Asher L. , Polo-Parada Luis , Baker Gary A.
Published: October 2022

Synthesis of gold nanostars utilizing a novel reducing agent coupled with in situ plasmon-mediated growth is demonstrated.
Hexanitrato complexes and hybrid double perovskites of Am3+and Cm3+
Authors: Tarlton Michael L. , Skanthakumar Suntharalingam , Vallet Valérie , Wilson Richard E.
Published: October 2022

Isostructural, homoleptic twelve-coordinate nitrato complexes of the 5f-ions Am and Cm are reported that occur as hybrid double perovskites.
Design of coordination polymers based on combinations of 1,2-diphenylethane-1,2-diyl diisonicotinate with Cu(ii), Zn(ii), Cd(ii) and Co(ii)
Authors: Zazouli Sofia , Gruber Nathalie , Bulach Véronique , Ferlay Sylvie , Jouaiti Abdelaziz
Published: October 2022

Five new supramolecular coordination polymers of different dimensionalities (L-Cu(acac)2, L-Cu(hfac)2, L-ZnCl2, L-CdI2 and L-CoCl2) based on the use of the flexible organic ligand L (1,2-diphenylethane-1,2-diyl diisonicotinate) are reported.
Complexation and organization of doxorubicin on polystyrene sulfonate chains: impacts on doxorubicin dimerization and quenching
Authors: Gjerde Natalie Solfrid , Nardi Alessandro Nicola , Chen Cheng Giuseppe , Di Gianvincenzo Paolo , D’Abramo Marco , Scipioni Anita , Galantini Luciano , Moya Sergio E. , Giustini Mauro
Published: October 2022

The doxorubicin hydrochloride (DX) interaction with polystyrene sulfonate leads to fluorescence quenching due to dimer formation.
Understanding the tunable sodium storage performance in pillared MXenes: a first-principles study
Authors: Dai Li , Zhao Jiahao , Li Qin , Chen Maohui , Li Haibo , Qu Konggang , Li Rui
Published: October 2022

On the basis of first-principles calculations, we studied the influence of the interlayer spacing and stacking modes of pillared MXenes on the sodium storage performance, and predicted the optimum structure for sodium storage.
Spontaneous magnetic merons in a half-metallic Mn2I3Br3 monolayer with easy-plane anisotropy
Authors: Shen Zhong , Xue Yufei , Wu Zebin , Song Changsheng
Published: October 2022

Spontaneous magnetic merons are found to exist in a wide magnetic field range (0–6 T) stabilized by the large in-plane magnetic anisotropy and strong Dzyaloshinskii–Moriya interaction in a half-metallic Mn2I3Br3 monolayer.
Silent transcription intervals and translational bursting lead to diverse phenotypic switching
Authors: Yang Xiyan , Luo Songhao , Zhang Zhenquan , Wang Zihao , Zhou Tianshou , Zhang Jiajun
Published: October 2022

For complex process of gene expression, we use theoretical analysis and stochastic simulations to study the phenotypic diversity induced by silent transcription intervals and translational bursting.
MoSSe/Hf(Zr)S2 heterostructures used for efficient Z-scheme photocatalytic water-splitting
Authors: Wang Guangzhao , Chang Junli , Guo San-Dong , Wu Weikang , Tang Wenyi , Guo Hao , Dang Suihu , Wang Rui , Ang Yee Sin
Published: October 2022

HfS2/SMoSe, HfS2/SeMoS, ZrS2/SMoSe, and ZrS2/SeMoS heterostructures are promising overall water-splitting photocatalysts.
Electrifying the production of sustainable aviation fuel: the risks, economics, and environmental benefits of emerging pathways including CO2
Authors: Grim R. Gary , Ravikumar Dwarak , Tan Eric C. D. , Huang Zhe , Ferrell Jack R. , Resch Michael , Li Zhenglong , Mevawala Chirag , Phillips Steven D. , Snowden-Swan Lesley , Tao Ling , Schaidle Joshua A.
Published: October 2022

Emerging CO2 to SAF pathways facilitates diversification of fuel production with the potential for a near carbon neutral footprint.
Novel methane activation by sulfur dioxide and molecular oxygen via trifluoroacetylsulfuric acid
Authors: Kim Sungah , Wang Jen-Chieh , Lee Joo Ho , Jung Kyung Woon
Published: October 2022

In an effort to combat air pollutants, we developed a new strategy to convert the greenhouse gas methane and toxic sulfur dioxide into value-added liquid methanesulfonic acid in high yield with the use of molecular oxygen under mild conditions.
The meaning of life … cycles: lessons from and for safe by design studies
Authors: Guinée Jeroen B. , Heijungs Reinout , Vijver Martina G. , Peijnenburg Willie J. G. M. , Villalba Mendez Gara
Published: October 2022

The meaning of the term ‘life cycle’ in relation to chemical, material and product in Safe-by-Design (SbD) studies is discussed. We recommend including explicit definitions and graphical representations of life cycles in future SbD work.
A green solvent-to-polymer upgrading approach to water-soluble LCST poly(N-substituted lactamide acrylate)s
Authors: Palà Marc , El Khannaji Hafssa , Garay-Sarmiento Manuela , Ronda Juan Carlos , Cádiz Virginia , Galià Marina , Percec Virgil , Rodriguez-Emmenegger César , Lligadas Gerard
Published: October 2022

A solvent-to-polymer upgrading strategy was developed to convert green solvents of the lactic acid portfolio into LCST-type acrylic polymers and hydrogels.
Electroreductive cross-coupling between aldehydes and ketones or imines via cathodically generated dianions
Authors: Wang Lu-Jun , Ye Peng , Tan Ninghua , Zhang Bo
Published: October 2022

An operationally simple electrochemical method for cross-coupling of aldehydes with ketones or imines using electrons as safe reductants is reported.
Tissue clearing of human iPSC-derived organ-chips enables high resolution imaging and analysis
Authors: Ondatje Briana N. , Sances Samuel , Workman Michael J. , Svendsen Clive N.
Published: October 2022

Optimization of SCALE protocol for organ-chips and organ-chip sections for improved visualization.
Orientational control of molecular scale thermoelectricity
Authors: Alshammari Majed , Al-Jobory Alaa A. , Alotaibi Turki , Lambert Colin J. , Ismael Ali
Published: October 2022

Through a comprehensive study, we demonstrate that single-molecule junctions formed from asymmetric molecules with different terminal groups can exhibit Seebeck coefficients, whose sign depends on the orientation of the molecule within the junction.
3D-phosphorus doped mesoporous graphitic carbon nitride based immunosensor for swine flu detection
Authors: Nirbhaya Vishakha , Kumar Yogesh , Chandra Ramesh , Kumar Suveen
Published: October 2022

Illustrative representation of the immunosensing platform and its electrochemical response for the detection of swine flu.
Radical spirocyclization of biaryl ynones for the construction of NO2-containing spiro[5.5]trienones
Authors: Xia Dong , Shen Liu-Yu , Zhang Yicheng , Yang Wen-Chao
Published: October 2022

An efficient 6-exo-trig radical cascade reaction of biaryl ynones with NaNO2 was developed to afford nitro-functionalized spiro[5.5]trienones with yields of up to 88%.
Hydrogenated ceria nanoparticles for high-efficiency silicate adsorption
Authors: Lee Kangchun , Kim Sungmin , Sun Seho , Lee Ganggyu , Kwon Jiseok , Hwang Junha , Seo Jihoon , Paik Ungyu , Song Taeseup
Published: October 2022

The enriched Ce3+ ions were confirmed on the surface of hydrogenated ceria nanoparticles which play a key role as active sites in various chemical reactions including silicate adsorption.
An electrochemical sensor–adsorbent for lead (Pb2+) ions in an aqueous environment based on Katiragum–Arginine Schiff base
Authors: Saren Rakesh Kumar , Banerjee Shankha , Mondal Barun , Senapati Sanjib , Tripathy Tridib
Published: October 2022

A dual functional material fulfilling twin objectives; simultaneous sensing and adsorption of Pb2+ ions in an aqueous medium.
Benzylic bromide induced peptide cross-linking for nanofiber assembly
Authors: Hu Xiao-Xiang , Zhang Meng , Xu Fei
Published: October 2022

Herein, we report a cross-linking method for the assembly of coiled-coil peptides into long fibers under mild conditions.
A straightforward access to trifluoromethylated natural products through late-stage functionalization
Authors: Li He-Ping , He Xiang-Hong , Peng Cheng , Li Jun-Long , Han Bo
Published: October 2022

This review summarizes the applications of late-stage strategies in the direct trifluoromethylation of natural products in the past ten years, with particular emphasis on the reaction model of each method.
Control of triboelectrification on Al–metal surfaces through microstructural design
Authors: Feng Min , Ma Shaochen , Liu Ying , Zheng Youbin , Feng Yange , Wang Hanchao , Cheng Jiahui , Wang Daoai
Published: October 2022

Micro/nano-AAO was fabricated on the surface of Al, and the short-circuit current was reduced 8.77 times through microstructure and composition regulation. Besides, a positive correlation between the contact area and the charge density was demonstrated.
Alloying strategies for tuning product selectivity during electrochemical CO2reduction over Cu
Authors: Mosali Venkata Sai Sriram , Bond Alan M. , Zhang Jie
Published: October 2022

Alloying is efficient for tuning product selectivity of copper in electrochemical reduction of CO2. Different alloying strategies and their impacts on product formation paths, the key challenges and future directions of the field have been reviewed.
Biomass derived self-assembled DNA-dot hydrogels for enhanced bacterial annihilation
Authors: Nayak Suman , Kumar Prakash , Shankar Ravi , Mukhopadhyay Asish Kumar , Mandal Debabrata , Das Prolay
Published: October 2022

Sustainable antibacterial hydrogel from hybridization mediated self-assembly of DNA Quantum Dot and genomic DNA extracted from onion.
Parallel DNA circuits by autocatalytic strand displacement and nanopore readout
Authors: Zhu Jinbo , Kong Jinglin , Keyser Ulrich F. , Wang Erkang
Published: October 2022

Parallel DNA circuits are constructed using autocatalytic strand displacement reactions and measured using a nanopore multiplexed sensing platform.
In situ Cu single atoms anchoring on MOF-derived porous TiO2 for the efficient separation of photon-generated carriers and photocatalytic H2 evolution
Authors: Ma Yuxiang , Zhang Yumin , Ma Yiwen , Lv Tianping , Xiao Bin , Kuang Xinya , Deng Xiyu , Zhang Jin , Zhao Jianhong , Liu Qingju
Published: October 2022

Reaction mechanism and photocatalytic hydrogen production of MOF-derived Cu-TiO2 single atom catalysts.
Facile chemoenzymatic synthesis of unmodified anticoagulant ultra-low molecular weight heparin
Authors: Zhang Guijiao , Yang Kaihua , Wang Lin , Cheng Yanzhen , Liu Chunhui
Published: October 2022

A chemoenzymatic approach, mimicking the biosynthetic pathway of heparin and heparan sulfate (HS), has been well developed to prepare a series of structurally well-defined heparin oligosaccharides with excellent anticoagulant activity in good overall yields.
Catalyst-free aerobic radical cascade reactions of o-vinylphenylisocyanides with thiols to access 2-thio-substituted quinolines
Authors: Wang Jin , Liu Haitao , Liu Yaohui , Hao Wanting , Yang Yingqi , Sun Yanan , Xu Xianxiu
Published: October 2022

We herein report an efficient and green aerobic radical cascade reaction of o-vinylphenylisocyanides with thiols to access a broad range of 2-thio-substituted quinolines without the need for additional catalysts or oxidants.
Salicornia dolichostachya organosolv fractionation: towards establishing a halophyte biorefinery
Authors: Monção Maxwel , Wretborn Tobias , Rova Ulrika , Matsakas Leonidas , Christakopoulos Paul
Published: October 2022

An organosolv method was developed for the fractionation of fibers of a halophyte plant in a biorefinery approach. Salicornia dolichostachya was used as raw material allowing the production of cellulose, hemicellulose, and lignin fractions.
Superiority of biomimetic micelle-entrapped nanoporous silica xerogel to deliver poorly water-soluble itraconazole
Authors: Li Xuejun , Li Dongyan , Liu Zhining
Published: October 2022

Micelle-entrapped silica xerogel (M-Silica xerogel) was biomimetically synthesized to combine the advantages of micelles and silica xerogel to load poorly water-soluble drug itraconazole (ITZ).
Quantum chemical modification of indaceno dithiophene-based small acceptor molecules with enhanced photovoltaic aspects for highly efficient organic solar cells
Authors: Rashid Ehsan Ullah , Hadia N. M. A. , Alaysuy Omaymah , Iqbal Javed , Hessien M. M. , Mersal Gaber A. M. , Mehmood Rana Farhat , Shawky Ahmed M. , Khan Muhammad Imran , Khera Rasheed Ahmad
Published: October 2022

In this work, with the aim of boosting the ultimate efficiency of organic solar cells, seven small acceptor molecules (IDST1–IDST7) were proposed by altering the terminal-acceptor of reference molecule IDSTR.
Retraction: The PI3K/Akt and NF-κB signaling pathways are involved in the protective effects of Lithocarpus polystachyus (sweet tea) on APAP-induced oxidative stress injury in mice
Authors: Yang Jia-yu , Zhong Yu-te , Hao Wei-nan , Liu Xiang-xiang , Shen Qiong , Li Yan-fei , Ren Shen , Wang Zi , Li Wei , Zhao Li-Chun
Published: October 2022

Retraction of ‘The PI3K/Akt and NF-κB signaling pathways are involved in the protective effects of Lithocarpus polystachyus (sweet tea) on APAP-induced oxidative stress injury in mice’ by Jia-yu Yang et al., RSC Adv., 2020, 10, 18044–18053. https://doi.org/10.1039/D0RA00020E.
Imaging strategies for monitoring the immune response
Authors: Liu Xiaohan , Pan Limeng , Wang Kaiye , Pan Wei , Li Na , Tang Bo
Published: October 2022

Immune-related imaging strategies, current problems and development direction are summarized and discussed in this paper.
All-natural gelatin-based bioorthogonal catalysts for efficient eradication of bacterial biofilms
Authors: Nabawy Ahmed , Huang Rui , Luther David C. , Zhang Xianzhi , Li Cheng-Hsuan , Makabenta Jessa Marie , Rotello Vincent M.
Published: October 2022

An all-natural biopolymer-based nanoemulsion catalyst for combatting MDR bacterial biofilms while maintaining excellent biocompatibility and biodegradability.
Organothianthrenium salts: synthesis and utilization
Authors: Meng Huan , Liu Ming-Shang , Shu Wei
Published: October 2022

This review summarizes the synthesis of diverse organothianthrenium salts from various precursors and their applications in organic synthesis to forge new C–C, C–H and C–heteroatom bonds by C–S bond cleavage with different mechanistic considerations.
A stable platinum porphyrin based photocatalyst for hydrogen production under visible light in water
Authors: Orfanos Emmanouil , Ladomenou Kalliopi , Angaridis Panagiotis A. , Papadopoulos Theodoros , Charalambidis Georgios , Vasilopoulou Maria , Coutsolelos Athanassios G.
Published: October 2022

A stable system containing a Pt metalated porphyrin as a molecular solid photocatalyst in acidic aqueous solution is able to produce hydrogen efficiently, under visible light irradiation.
Equilibrium morphology of tactoids in elastically anisotropic nematics
Authors: Schimming Cody D. , Viñals Jorge
Published: October 2022

Anisotropic elasticity in nematic liquid crystals leads to sharper surface defects in negative tactoids and more elongated positive tactoids. In addition, the growth kinetics of tactoids is highly sensitive to the anisotropic elastic energy.
Development of a transferable coarse-grained model of polydimethylsiloxane
Authors: Cambiaso Sonia , Rasera Fabio , Rossi Giulia , Bochicchio Davide
Published: October 2022

Development of a transferable coarse-grained model of polydimethylsiloxane, a popular silicon based polymer with advanced applications in microfluidics and nanocomposites.
Correction: Interpenetration of fractal clusters drives elasticity in colloidal gels formed upon flow cessation
Authors: Dagès Noémie , Bouthier Louis V. , Matthews Lauren , Manneville Sébastien , Divoux Thibaut , Poulesquen Arnaud , Gibaud Thomas
Published: October 2022

Correction for ‘Interpenetration of fractal clusters drives elasticity in colloidal gels formed upon flow cessation’ by Noémie Dagès et al., Soft Matter, 2022, 18, 6645–6659, https://doi.org/10.1039/D2SM00481J.
Eco-Evo-Devo of petal pigmentation patterning
Authors: Fairnie Alice L.M , Yeo May T.S. , Gatti Stefano , Chan Emily , Travaglia Valentina , Walker Joseph F. , Moyroud Edwige
Published: October 2022

Colourful spots, stripes and rings decorate the corolla of most flowering plants and fulfil important biotic and abiotic functions. Spatial differences in the pigmentation of epidermal cells can create these patterns. The last few years have yielded new data that have started to illuminate the mechanisms controlling the function, formation and evolution of petal patterns. These advances have broad impacts beyond the immediate field as pigmentation patterns are wonderful systems to explore multiscale biological problems: from understanding how cells make decisions at the microscale to examining the roots of biodiversity at the macroscale. These new results also reveal there is more to petal patterning than meets the eye, opening up a brand new area of investigation. In this mini-review, we summarise our current knowledge on the Eco-Evo-Devo of petal pigmentation patterns and discuss some of the most exciting yet unanswered questions that represent avenues for future research.
Pathogens transported by plastic debris: does this vector pose a risk to aquatic organisms?
Authors: Bowley Jake , Baker-Austin Craig , Michell Steve , Lewis Ceri
Published: October 2022

Microplastics are small (<5 mm) plastic particles of varying shapes and polymer types that are now widespread global contaminants of marine and freshwater ecosystems. Various estimates suggest that several trillions of microplastic particles are present in our global oceanic system, and that these are readily ingested by a wide range of marine and freshwater species across feeding modes and ecological niches. Here, we present some of the key and pressing issues associated with these globally important contaminants from a microbiological perspective. We discuss the potential mechanisms of pathogen attachment to plastic surfaces. We then describe the ability of pathogens (both human and animal) to form biofilms on microplastics, as well as dispersal of these bacteria, which might lead to their uptake into aquatic species ingesting microplastic particles. Finally, we discuss the role of a changing oceanic system on the potential of microplastic-associated pathogens to cause various disease outcomes using numerous case studies. We set out some key and imperative research questions regarding this globally important issue and present a methodological framework to study how and why plastic-associated pathogens should be addressed.
A modified extended min‐sum algorithm based on posterior probability thresholding for non‐binary low‐density parity‐check codes
Authors: Zhao Yatong , Wang Liqian , Zhu Miao , Wang Weiming , Tao Kai , Shi Yinlong , Chen Xue
Published: October 2022

This letter focuses on improving the error correction performance of the extended min‐sum (EMS) decoding algorithm. Introducing factor/offset modifications in the check node update process of the EMS algorithm can improve the performance. Based on this, the authors propose a novel threshold‐based modified EMS algorithm that introduces the factor/offset in a targeted manner by setting a threshold for the posterior probability. Simulation results show that an additional performance gain of the order of 0.08 dB is obtained with the proposed method without significantly increasing the complexity of the method.
Improving CME evolution and arrival predictions with AMR and grid stretching in Icarus
Authors: Baratashvili T. , Verbeke C. , Wijsen N. , Poedts S.
Published: October 2022

Context.Coronal mass ejections (CMEs) are one of the main drivers of disturbances in interplanetary space. Strong CMEs, when directed towards the Earth, cause geomagnetic storms upon interacting with the Earth’s magnetic field, and can cause significant damage to our planet and affect everyday life. As such, efficient space weather prediction tools are necessary to forecast the arrival and impact of CME eruptions. Recently, a new heliospheric model called Icarus was developed based on MPI-AMRVAC, which is a 3D ideal magnetohydrodynamics model for the solar wind and CME propagation, and it introduces advanced numerical techniques to make the simulations more efficient. In this model the reference frame is chosen to be co-rotating with the Sun, and radial grid stretching together with adaptive mesh refinement (AMR) can be applied to the numerical domain.

Aims.Grid stretching and AMR speed up simulation results and performance. Our aim is to combine the advanced techniques available in the Icarus model in order to obtain better results with fewer computational resources than with the equidistant grid. Different AMR strategies are suggested, depending on the purpose of the simulation.

Methods.In this study, we model the CME event that occurred on July 12, 2012. A cone model was used to study the CME’s evolution through the background solar wind, and its arrival at and impact with the Earth. Grid stretching and AMR were combined in the simulations by using multiple refinement criteria, to assess its influence on the simulations’ accuracy and the required computational resources. We compare simulation results to the EUHFORIA model.

Results.We applied different refinement criteria to investigate the potential of solution AMR for different applications. As a result, the simulations were sped up by a factor of ∼17 for the most optimal configuration in Icarus. For the cone CME model, we found that limiting the AMR to the region around the CME-driven shock yields the best results. The results modelled by the simulations with radial grid stretching and AMR level 4 are similar to the results provided by the original EUHFORIA and Icarus simulations with the ‘standard’ resolution and equidistant grids. The simulations with 5 AMR levels yielded better results than the simulations with an equidistant grid and standard resolution.

Conclusions.Solution AMR is flexible and provides the user the freedom to modify and locally increase the grid resolution according to the purpose of the simulation. We find that simulations with a combination of grid stretching and AMR can reproduce the simulations performed on equidistant grids significantly faster. The advanced techniques implemented in Icarus can be further used to improve the forecasting procedures, since the reduced simulation time is essential to make physics-based forecasts less computationally expensive.
Using LSST late-time photometry to constrain Type Ibc supernovae and their progenitors
Authors: Dessart Luc , Prieto Jose L. , Hillier D. John , Kuncarayakti Hanindyo , Hueichapan Emilio D.
Published: October 2022

Over its lifespan, theVera C. RubinObservatory Legacy Survey of Space and Time (LSST) will monitor millions of supernovae (SNe) from explosion to oblivion, yielding an unprecedentedugrizyphotometric dataset based on their late-time evolution. Here, we show that the photometric evolution of Type Ibc SNe can be used to constrain numerous properties of their ejecta, without the need for expensive spectroscopic observations. Using radiative-transfer simulations for explosions of He-star progenitors of different initial masses, we show that theg-band filter primarily follows the strength of the Fe IIemission, ther-band [O I]λλ6300,  6364 and [N II]λλ6548,  6583, thei-band [Ca II]λλ7291,  7323, and thez-band the Ca IIλλ 8498 − 8662 triplet, hence providing information on nucleosynthetic yields. Information on weaker lines that may be used, for example, to constrain clumping is absent. However, this deficiency may eventually be resolved by improving the physical realism of radiative-transfer simulations through a closer connection to physically consistent 3D explosion models, as well as through the judicial selection of a much smaller set of spectral observations. Degeneracies inherent to the SN radiation will affect the interpretation of photometric measures, but line fluxes from nebular-phase spectra are similarly compromised. Importantly, our “family” of Type Ibc SN models follows a distinct trajectory in color-color magnitude diagrams as the ejecta evolve from 100 to 450 d, allowing for the disentanglement of different progenitors or explosions. This photometric procedure provides a promising approach to studying statistical samples of SNe Ibc and confronting them with consistently improving progenitor and explosion models, as well as capturing the onset of late-time interaction with circumstellar material or identifying events currently unknown.
Analyses of the composite yield per recruit model CYPR14 for inferring plausible fishing mortality targets of fish in the tropics
Authors: Munyandorero Joseph
Published: October 2022

Stocks' yield and size per recruit are widely used to provide fisheries management guidance. This study provides details for analyzing the composite (i.e. age-aggregated or stage-structured) yield per recruit (CYPR) model CYPR14, and proposes CYPR14 as a management tool for tropical fisheries. The fishing mortality rates maximizing CYPR (FCYPR) and associated with the marginal increase in CYPR (F0.1) and a target composite spawning potential ratio (CSPR;F35%CSPRorF40%CSPR) were suggested as candidate fishing mortality targets, provided assessments employ the delay-differential model underlying CYPR14. Using Monte Carlo (MC) simulations relying on growth parameters and natural mortality of Lake Tanganyika'sLates stappersiiand Lake Victoria'sLates niloticus, CYPR14 analyses involving maximum survivorship or declining survivorship were carried out to show howFCYPR,F0.1,F35%CSPR, andF40%CSPRcould be generated, given an age of knife-edge recruitment (r). Baseline MC employedr = 1 year and yielded mean annual rates ofFCYPR = 0.52,F0.1 = 0.33, andF35%CSPR = 0.51 forL. stappersiiandFCYPR = 0.23,F0.1 = 0.14, andF40%CSPR = 0.16 forL. niloticus. CYPR14 with maximum survivorship produced CYPR isopleths such that the CYPR maximized at an infiniterand finite, higherF. For CYPR14 involving a declining survivorship, the CYPR declined with increasedrand maximized with innermost closed-loop contours at lowerFand an optimal age. The CSPR isopleths from both types of CYPR14 analyses were first concave down, and the optimal age served as their inflection point. In terms of benchmarks based on the maximum sustainable yield and of proxies thereof, CYPR14 should be for its underlying delay-differential model what the age-structured pool models are for age-structured assessment models.
Vérités scientifiques et enjeux sociaux
Authors: Gargani Julien , Jacq Annick , Gispert Hélène , Brunet Philippe
Published: October 2022

Le colloque « Vérités scientifiques et enjeux sociaux » a permis de nourrir une réflexion sur l’organisation des sciences en lien avec la production des preuves scientifiques et leurs modes de partage. Comment faire émerger la diversité des enjeux sociaux dans les sciences ? Comment partager plus largement la production scientifique et celle des preuves ? Les modes de production, de validation et de partage des preuves ne sont pas figés, ce qui les rend difficiles à appréhender. Les écueils et les mécanismes favorisant la fabrication de l’ignorance ont ainsi été abordés. L’interdisciplinarité, les sciences inclusives et les synthèses scientifiques collectives, thèmes évoqués lors du colloque, sont autant de pistes pour éclairer les débats publics, partager autrement les preuves et la capacité d’expertise, et définir collectivement les enjeux.
Nahrungsmittelunverträglichkeiten – „wenn
Essen krank macht“
Authors: Magistro Manuel
Published: October 2022

Unklare abdominelle Beschwerden wie Bauchschmerzen, Durchfälle,
Blähungen, Verstopfung oder Unwohlsein sind häufige
Beratungsanlässe in der allgemeinmedizinischen Sprechstunde. Oft
verbergen sich hinter diesen Beschwerden
Nahrungsmittelunverträglichkeiten, vor allem in Bezug auf Laktose,
Fruktose und Histamin. Der Beitrag erklärt die pathophysiologischen
Mechanismen und stellt praxisnah (Differenzial-) Diagnosen und therapeutische
Optionen vor.
Head and Neck Ultrasound – EFSUMB Training Recommendations
for the Practice of Medical Ultrasound in Europe
Authors: Todsen Tobias , Ewertsen Caroline , Jenssen Christian , Evans Rhodri , Kuenzel Julian
Published: October 2022

Different surgical and medical specialists increasingly use head and neck
ultrasound and ultrasound-guided interventions as part of their clinical
practice. We need to ensure high quality and standardized practice across
specialties, and this position paper of the European Federation of Societies for
Ultrasound in Medicine and Biology (EFSUMB) describes the training requirements
for head and neck ultrasound. Traditionally, a minimum number of ultrasound
examinations indicates competence, but this is unreliable, and a general shift
towards competence-based training is ongoing. For each EFSUMB level, we will
outline the theoretical knowledge and skills needed for clinical practice. The
recommendations follow the three EFSUMB competency levels for medical ultrasound
practice. Level 1 describes the skills required to perform essential head and
neck ultrasound examinations independently, level 2 includes ultrasound-guided
interventions, while level 3 involves the practice of high-level neck ultrasound
and use of advanced technologies. Our goal is to ensure high quality and
standardized head and neck ultrasound practice performed by different clinical
specialists with these recommendations.
Associations of PNPLA3 rs738409 Polymorphism with Plasma Lipid
Levels: A Systematic Review and Meta-Analysis
Authors: Luo Zhi , Liu Yang , Li Hang , Zhou Yawen , Peng Yuanyuan , Lin Xuan , Fang Ying , Wan Jing , Wei Baozhu
Published: October 2022

Accumulating evidence has shown that the rs738409 polymorphism of patatin-like
phospholipase domain-containing 3 (PNPLA3) is associated with non-alcoholic
fatty liver disease (NAFLD). Since NAFLD has been reported to be associated with
lipid metabolism, this study is conducted to explore whether the rs738409
polymorphism of PNPLA3 was associated with lipid levels. By searching PubMed and
the Cochrane database from May 31, 2020, to June 30, 2021. Sixty-three studies
(81 003 subjects) were included for the analysis. The consistent findings for
the associations of rs738409 polymorphism with lipid levels were the
significantly decreased triglycerides (TG) (SMD=−0.04,
95% CI=−0.07 to −0.01, p=0.02) and total
cholesterol (TC) (SMD=−0.03, 95%
CI=−0.05 to −0.01, p<0.01) levels. Subgroup
analysis indicated that the associations of rs738409 polymorphism with TG and TC
levels were stronger in Caucasians, obesity patients, and adult subjects than in
Asians, T2DM patients, and children subjects. The rs738409 polymorphism of
PNPLA3 was associated with lower TG and TC levels in Caucasians, obese and adult
subjects, which may contribute to the reduced coronary artery disease (CAD) risk
between PNPLA3 rs738409 polymorphism and CAD.
Effect of Cabergoline Treatment on Disease Control in Acromegaly
Patients
Authors: Hacisahinogullari Hulya , Yalin Gulsah Yenidunya , Selcukbiricik Ozlem Soyluk , Gul Nurdan , Bilgic Bilge , Uzum Ayse Kubat , Tanakol Refik , Aral Ferihan
Published: October 2022

The aim of this study was to evaluate the efficacy of cabergoline in normalizing
plasma IGF-I levels in acromegaly patients with elevated IGF-I levels after
surgery and/or SRL therapy. Acromegaly patients (n: 143) were evaluated
retrospectively. Patients with elevated IGF-I levels after surgery
and/or SRLs therapy and a fixed dose of SRLs treatment for the last six
months with no history of radiotherapy in the last three years were included in
the study (n: 12). Previous treatment regimens, baseline PRL and IGF-I levels
(ULNR), sella MRI, and immunohistochemical findings were evaluated. Cabergoline
was used as an add on (n: 11) or single medical treatment (n: 1). The median
duration of treatment with SRL alone was 12 months (range 6–48 months).
The mean IGF-I value before cabergoline therapy was 1.45±0.4 ULNR. The
mean cabergoline dose and duration of treatment were
1.55±0.75 mg/week and 9±6.3 months,
respectively. IGF-I normalization was only achieved in patients with serum IGF-I
concentration<1.5×ULNR before the onset of cabergoline treatment
(n: 9). In some of the patients with IGF-I normalization, baseline prolactin
levels were normal (n: 3). Immunopositivity for prolactin in adenoma tissue was
found in three patients with IGF-I normalization. Cabergoline therapy is
effective in the normalization of IGF-I levels even in normoprolactinemic
acromegaly patients when IGF-I levels are mildly or moderately elevated during
SRL therapy.