bluuebunny/crossref_metadata_2025 huggingface dataset:
JUSTIFICATION OF REINFORCEMENT PARAMETERS FOR PRODUCTS MADE OF NATURAL STONE WITH STEEL AND COMPOSITE CORES
Authors: Kotenko Volodymyr  , Ostafychuk Nelya  , Piskun Ihor  , Kunytska Maryna  , Sydorenko Andriy
Published: July 2023

Purpose. The objective of this study is to investigate the feasibility of using steel and composite reinforcement to enhance the strength characteristics of products made of natural stone.

Methodology. The preparation of specimens for conducting strength tests is performed and described. Recommendations are provided for the preparation, configuration, and utilization of the main tools and materials involved in the research. The components of the experiment aimed at determining the strength characteristics of the specimens are developed and described. Based on the obtained data, calculations of the primary force parameters during the failure of the specimens under bending loads are carried out.

Results. The research findings on the application of steel and composite reinforcement methods to improve the strength properties of stone products revealed that the use of composite reinforcement consistently increases deformation under higher loads, indicating better control of plastic deformation compared to steel reinforcement. However, the ultimate strength and load-bearing capacity of specimens reinforced with composite reinforcement are lower than those reinforced with steel reinforcement.

Scientific novelty lies in the systematic analysis and comparison of the effectiveness of different types of reinforcement in enhancing the strength characteristics of products made of natural stone, as well as in the development of methodology and experimental procedures for determining force parameters. The obtained results indicate the potential of composite reinforcement for controlled plastic deformation and establish limitations regarding ultimate strength and load-bearing capacity.

Practical significance of the research lies in providing recommendations and information that can be utilized by designers, engineers, and construction professionals in the manufacturing of products made of natural stone, as well as in the planning and implementation of construction projects involving natural stone.
ANALYSIS OF APPLICATION EFFICIENCY OF SINGLE AND DOUBLE ROW MECHANISED FIXTURES IN THE CONDITIONS OF SYNCHRONIZATION OF MINING WORKS AND FLOODING OF MINES
Authors: Vlasov Sergey , Sadovenko Ivan , Moldavanov Yavhen , Timchenko Svetlana
Published: July 2023

Purpose. Determination of a rational option for using a type of mechanized fastening in the conditions of simultaneous flooding of mines and mining operations, taking into account the manifestations of hydrostatic pressure formed in the main roof of the coal seam.

Method. The research used the method of numerical modelling and analysis of the displacement of the sole and roof of the coal seam and the prediction of the step-by-step progress of the cleaning pit in the layered transversely isotropic massif of rocks using the Solid Works 2019 software package.

Results. Obtained statistical parameters of the use of mechanized fastening in the hydrogeotechnical conditions of the mines of Western Donbas based on the collected actual data of the mining enterprises of PJSC «DTEK Pavlogradvugillia». The reasonable feasibility of using a supporting and fencing four-pillar, two-row mechanized fastening of the KD-80 type by comparing the results of modelling its operation with a two-pillar single-row fastening of the Ostroj-70/125 type in conditions of a layered massif with manifestations of hydrostatic pressure.

Scientific novelty. For the first time, a geotechnical forecast was performed on the basis of numerical comparative modelling of the operation of single- and double-row mechanized fasteners in the conditions of simultaneous flooding of the mine and mining operations, taking into account the manifestations of hydrostatic pressure, which is formed in the main roof of the coal seams of the mines of Western Donbas. When using two-pillar single-row fastening, the value of convergence can increase by more than 33%, in comparison with four-pillar two-row mechanized fastening of the support-fencing type.

Practical significance. The research results make it possible to determine a rational option for using the type of mechanized fastenings for the complicated hydrotechnical conditions of coal mining from ultra-thin coal seams of the mines of Western Donbas, as well as to develop recommendations for technological improvement of mining operations, to minimize accidents associated with the subsidence of sections of mechanized fastening «on hard base», which significantly increases the efficiency of coal mining.
EXPERIMENTAL RESEARCH AND DEVELOPMENT OF A METHOD FOR CALCULATING THE PARAMETERS OF BOREHOLE HYDROMONITOR DISINTEGRATION OF RICH IRON ORE IN PLACE
Authors: Tarasyutin Viktor  , Kosenko Andrii  , Khomenko Oleh  , Kononenko Maksym
Published: July 2023

Purpose. Study and development of a rational methodology for calculating the parameters of the process of downhole hydrodisintegration of martite ore massifs by pressure rotating water jets.

Methods. Mine experimental-methodical and experimental-experimental works on: stage-by-stage study of the engineering and geological situation of ore deposits and selection of experimental sites; development of technological schemes for the hydrodisintegration of the ore in place and the creation of appropriate experimental equipment; selection of means for providing hydro-extracting operations; the choice of methods for monitoring and measuring the parameters of the hydrodisintegration process; generalization and analysis of the results of experiments and development of recommendations for the creation of technology and equipment, taking into account the achieved indicators.

Results. A technique for calculating the parameters of hydrodisintegration of rich martite ores martite ore in places has been developed based on the study of the features of the formation of rotating compact water jets by borehole hydromonitors.

Scientific novelty. Relationships between the structural and morphological characteristics and jointing of martite ores (porosity, the ratio of the grain composition of the ore, the ultimate uniaxial compression strength of ore and lumpiness) and the parameters of the hydromonitoring effect (water pressure, the initial diameter of the jet and the speed of its movement along the exposure of the face), which make it possible to determine rational technological parameters of hydrodisintegration products.

Practical implication. Borehole hydromonitor disintegration of martite ores in place is a combined ore preparation process, including enrichment grinding operations and classification of destruction products according to their granulometric composition during their erosion. At the same time, there is a selective opening of ore-forming minerals that improve the quality of the ore by 0.5–1.5% compared to natural, a decrease in the mass fraction of silica from 2.0–1.2 to 0.5–0.3%, which ensures the production of iron ore raw materials of the highest quality – superconcentrates with an iron content of 69.0–69.5%. Control of the granulometric composition of hydrodisintegration products is achieved by adjusting the initial water pressure at the outlet of the jet nozzle, the speed of the jet along the face exposure and the orientation of the jet relative to the elements of occurrence and texture of the ores.
Aplicações da ozonioterapia na clínica veterinária
Authors: Penido Bruno Rocha , Lima Camila de Aguiar , Ferreira Luiz Fernando Lucas
Published: August 2023

Ozone, allotropic form of oxygen, is an unstable gas, colorless and odor characteristics at room temperature. Since 1840, this gas has been studied by doctors and researchers around the world. Besides being present in the stratosphere and contribute to filtration of UV light, ozone has been estimated to be used for medicinal purposes. This gas has a high oxidizing power, as well as antibacterial, fungicidal and viral. So, apparently the ozone can be used to treat various diseases, such as arterial circulatory diseases, external ulcers, skin lesions, immunodeficiency, hepatitis, supportive therapy in patients with cancer, inflammation and dental care. It should be emphasized however that the ozone therapy should not be the main therapy in the treatment of diseases and should be used as adjuvant therapy. The literature also cites several possibilities of using ozone therapy to both large and small animals, however, there are studies showing that the effectiveness of the treatment of certain diseases, it is necessary to use high concentrations of the gas, leading to significant adverse effects. Ozone also has other applications, such as sterilization of materials (since the gas rapidly inactivates microorganisms) and also water. Since its use in air purifier is still controversial. Considering these aspects, we see that the discussions on the subject are still controversial, and further studies are necessary for further elucidation on this therapy. It is worth noting that in veterinary medicine, there are even fewer studies, which once again reminds us of the need for further research.
Calcinose cutânea em cão com hipercortisolismo: Relato de caso
Authors: Bessa Lucas , Rafael Gabriel Henrique , Teixeira Monalisa Jales , Mencalha Renata Novais
Published: July 2023

Cutaneous calcinosis in dogs is a dermatological condition that involves the deposition of calcium salts in the animals' skin. Its etiology has not yet been fully established, but it is believed that genetic, nutritional and metabolic factors may play an important role in the development of the disease. It is divided into four subtypes, according to its pathogenesis: dystrophic; metastatic; idiopathic and iatrogenic, with dystrophic being the most common. Hypercortisolism, also known as Cushing's syndrome, is one of the main causes of cutaneous calcinosis in dogs. In this condition, there is excessive production of cortisol by the adrenal glands, leading to a series of metabolic, immune and inflammatory changes that contribute to the formation of calcium deposits in the skin. Symptoms can vary, but they usually manifest as the formation of hard, white subcutaneous nodules that may ulcerate or leak creamy material. Diagnosis is performed through clinical and laboratory examinations, such as cytology of the nodules, biopsy, and laboratory tests. Treatment aims to control the underlying disease and provide local care, but it is quite challenging as there is no specific established therapy. This study aimed to report the case of a dog diagnosed with hypercortisolism, presenting secondary cutaneous calcinosis.
Utilização do retalho de padrão subdérmico inguinal bilateral e da tela de polipropileno após ressecção de neoplasma mamário: Relato de caso
Authors: Silva Kamila Cristina Martins da , Martins Victoria Rabelo Vieira Assad , Nascimento Vitor Pereira , Rodrigues Robertson Bastos , Dos Santos Jenifer Oliveira , Madeira Matheus Costa , Souza Thiago Martins , Serra Thaís Bastos Rocha , De Oliveira Rudson Almeida , Martins Nathálya dos Santos
Published: July 2023

The use of reconstructive surgery techniques is increasingly common in veterinary medicine for the tissue reconstruction of wounds, whether due to trauma or tumor excision, improving functionality and maintaining pleasant aesthetics. The choice of technique to be used depends on the location of the wound, size, tension lines, skin availability and the surgeon's experience regarding the technique to be used. These procedures require a broad vascular anatomical knowledge from the surgeon, in order to achieve the success of the surgical technique, avoiding possible postoperative complications. The present work aims to evaluate the use of the bilateral inguinal subdermal pattern flap and the polypropylene mesh after resection of a mammary neoplasm in a cat, SRD, 15 years old, spayed and with a history of tumor recurrence. As postoperative complications there was only the formation of a small amount of inflammatory liquid, however the applied technique obtained a positive result in the repair of an extensive surgically created cutaneous defect.
Estafilectomia e rinoplastia em Bulldog francês: Relato de caso
Authors: Serra Thaís Bastos Rocha , Da Silva Kamila Cristina Martins , Martins Victoria Rabelo Vieira Assad , Mendes Ana Karoline Sampaio , Nascimento Vitor Pereira , Rodrigues Robertson Bastos , Madeira Matheus Costa , De Oliveira Rudson Almeida , Muller Fernanda , Martins Nathálya dos Santos
Published: July 2023

Brachycephalic obstructive respiratory syndrome (BRS) is characterized by anatomical and physiological changes that cause significant obstruction of the upper airways and predominantly affect dogs of brachycephalic breeds. These anatomical alterations can be classified as primary, such as nostril stenosis, soft palate prolongation and tracheal hypoplasia, and secondary, usually caused by increased turbulence and air resistance, such as eversion of laryngeal sacs, edema, nasopharyngeal inflammation, paralysis and laryngeal collapse. The evolution of these alterations may occur with age, developing into more serious respiratory diseases and even leading the patient to death. The objective of this report was to report the clinical surgical case of a canine, French bulldog, submitted to rhinoplasty and staphylectomy procedures. The patient was admitted with difficulty breathing when subjected to exercise, dyspnea, snoring, restlessness, and occasionally regurgitating food. Upon physical examination, this was found to be due to a brachycephalic syndrome, in which he had nostril stenosis and inspiratory stridor, suggesting soft palate prolongation. The patient was referred for corrective rhinoplasty surgery and staphylectomy. The procedure was performed, with a good prognosis and significant improvement in quality of life.
Estação curta de monta controlada com ovelhas Santa Inês criadas sob clima tropical úmido
Authors: Alvares Caio Tacito , Mondes Pedro Henrique Lima
Published: July 2023

The objective of this work was to evaluate the adoption of management techniques that could allow for a shorter controlled breeding season. In three consecutive mating seasons (MS1: September/2021, n=45; MS2: June/2022, n=42 and MS3: March/2023, n=43), lactating Santa Ines ewes, multiparous, aged between two and four years, mean live weight of 62.20 ± 4.60 kg and mean body condition score of 3.4 ± 0.4 (scale 1-5), two vasectomized males and two breeding rams with prior andrological evaluation, one Santa Ines and one Dorper. A pre-mating period was implemented with biostimulation using vasectomized males for 21 days. After this period, on day 0 (D0), an IM injection of 120.5µg of cloprostenol, a prostaglandin F2alpha analogue (PGF2α), was performed and estrus was observed until D3; ewes with identified estrus were mated by the breeding rams, as per controlled breeding. Ewes that did not show estrus were submitted to a second IM injection of PGF2α seven days after the first dose (D7), then repeating the management of estrus observation and controlled mating. Ewes were allowed three attempts at conception. Pregnancy diagnosis was performed by ultrasonography (D30). During biostimulation, 100% of the ewes showed estrus in the three mating seasons. There was no significant difference in performance between seasons (P>0.05). From the total of ewes in season (n= 130), 90.0% (n=117) became pregnant, 71.5% (n=93) in the first, 13.9% (n=18) in the second and 4.6% (n= 6) in the third mating. Prior biostimulation was efficient in inducing estrus to lactating Santa Ines ewes and the use of PGF2α was sufficient to synchronize estrus and generate a shorter controlled breeding season with up to three matings, presenting an efficient method to concentrate births and standardize allotments of lambs in a production system under humid tropical climate.
Impactos causados pela COVID-19 em indústrias de cárneos localizadas no Distrito Federal e Goiás
Authors: Cirqueira de Souza Fauane , Santana2 Ângela Patrícia
Published: July 2023

The SARS-CoV-2 virus, responsible for COVID-19, spreads more easily in crowded places, including slaughterhouses and meat processing factories, which employ over 560,000 workers in Brazil. However, there is still limited information on how the pandemic has affected meat processing plants in the Federal District and Goiás. Therefore, this study aimed to determine the main operational and structural changes adopted for disease control. The study involved the participation of 15 micro, small, and medium-sized companies, which together employ more than 1,500 workers in cattle, poultry, and swine slaughterhouses, meat processing units, and distribution centers. The study material was obtained through an online questionnaire directed at technical managers, agricultural inspectors, quality control teams and industry managers. The questions focused on potential structural and operational changes that occurred during this period, human resources and employee health, product logistics, and microbiological quality of the produced food. The statistical analysis revealed that 93% of the factories developed contingency plans. Among the changes implemented, 40% introduced a 1-meter distance between workstations, 33.3% increased the frequency of Sanitation Standard Operating Procedures (SSOPs), and 27% modified the layout of workstations to avoid face-to-face contact. Approximately 80% of the companies reported confirmed cases of COVID-19, with the majority (66.7%) choosing to isolate suspected employees and providing them paid medical leave (86%). Regarding finished products, there were challenges in customer delivery (71.4%), while 26.7% of the companies showed an improvement in microbiological quality. No establishments needed to close for procedure revisions related to pandemic control. The contingency plans followed Joint Ordinance nº 19/2020 (MAPA/MS/ME) and primarily aimed to ensure social distancing. However, promoting distance between workstations proved challenging due to the internal organization of meat factories. The pandemic recommendations did not replace existing legal obligations, and companies had to further emphasize their responsibility toward public health.
Model of NFT Implementation on Web SSO over OpenID Connect and Oauth 2.0 protocols
Authors: Fauzi Esa , Yuliani Sy , Syukriyah Yenie , Zakiah Azizah
Published: July 2023

Single Sign-On (SSO) is a mechanism that allows users to access various services using a single set of login credentials. However, in SSO implementations, there are still challenges related to security and authentication management, particularly attacks targeting the Identity Provider (IDP). To address this, the use of Non-Fungible Tokens (NFTs) as proof of IDP ownership has been proposed as a solution to enhance security in the authentication mechanism. The utilization of NFTs in SSO with OpenID Connect and OAuth 2.0 has the potential to improve security and convenience in the authentication process due to the unique and non-duplicable nature of NFTs. The results of this research present a model and design of SSO with NFTs on OpenID Connect and OAuth 2.0. An SSO application with login, register, and password recovery features was also developed to provide convenience to users during the login process. The findings conclude that the utilization of NFTs in SSO with OpenID Connect and OAuth 2.0 has the potential to enhance security and convenience in the authentication mechanism. Further research is needed to explore aspects such as scalability, in-depth security analysis, testing in real-world scenarios, improvement of integration and interoperability, as well as comparative analysis with other SSO technologies.
Sistem Informasi Persewaan Alat Pesta Berbasis Web Pada Afiska Alat Pesta
Authors: Yuniar Endah Metta , Murti Hari
Published: July 2023

Afiska alat pesta adalah perusahaan yang menyewakan perlengkapan pesta seperti sound system, lighting, perlengkapan panggung, listrik dan tenda. Saat ini Afiska alat pesta masih menggunakan sistem tradisional untuk mencatat peristiwa, membuat laporan, dan menyimpan data. Hal ini dapat menyebabkan kesalahan dalam proses pendaftaran, kesalahan dalam laporan yang dihasilkan dan waktu yang dibutuhkan untuk mencari informasi yang diperlukan. Sistem informasi persewaan berbasis web dibuat untuk mengatasi permasalahan yang ada saat ini. Menyimpan, menyimpan, dan mengambil data menjadi mudah dengan sistem ini. Metode penelitian yang digunakan dalam pembuatan sistem ini adalah metode waterfall. Hasil dari penelitian ini berupa sistem informasi yang memudahkan kerja Afiska sebagai alat pihak dalam pencatatan, pelaporan dan penyimpanan data acara. Sistem ini dapat dikembangkan lebih lanjut lebih baik lagi sesuai dengan perkembangan teknologi saat ini, sehingga pada penelitian selanjutnya diharapkan dapat menambahkan fungsi yang lebih lengkap lagi.
Analisis Risiko Proses Bongkar Muat Curah Kering Dengan Menggunakan Metode FMEA (Failure Mode And Effect Analysis) Di PT.XYZ
Authors: Aufa Aqil Firdaus , Dahda Said Salim
Published: July 2023

Pelabuhan merupakan suatu lokasi yang memiliki peran penting dan krusial dalam perkembangan industri dan perdagangan di suatu wilayah, serta merupakan salah satu kegiatan perdagangan yang berpotensi memberikan kontribusi bagi pertumbuhan dan perkembangan suatu negara. Hal ini berdampak pada pengelolaan sektor usaha kepelabuhanan yang harus dibenahi sebelum kegiatan operasional dapat dilakukan secara efektif, efisien, dan profesional. Hanya dengan begitu layanan pelabuhan dapat disediakan dengan cara yang bebas gangguan, aman, dan cepat dengan harga yang wajar. Penelitian ini bertujuan untuk (1) mengestimasi nilai RPN (Risk Priority Number) untuk risiko kegagalan proses bongkar muat; dan (2) memberikan ide untuk meminimalkan yang terjadi selama proses bongkar muat. Kedua tujuan ini akan dicapai melalui pengumpulan data dan penggunaan analisis statistik. Pendekatan FMEA (Failure Mode and Effect Analysis) akan digunakan untuk tujuan penelitian ini. Hal ini dimaksudkan agar tingkat resiko yang tinggi dapat diketahui, dan penanggulangan dapat dilaksanakan, sehingga tidak mengganggu proses bongkar muat. Berdasarkan nilai RPN (Risk Priority Number), terdapat 3 (tiga) jenis risiko yang paling tinggi, yaitu salah satunya sirkulasi truk tidak lancar dengan nilai 192; lainnya adalah pengaruh cuaca, yang memiliki nilai 105; dan yang ketiga adalah adanya kendala saat penimbangan yaitu nilai 84. Dan setelah itu dilakukan prosedur settlement untuk resiko terbesar yaitu alokasi stockpile atau gudang yang dekat dengan pelabuhan perusahaan jika barang terlalu jauh atau terblokir di perusahaan.

Kata Kunci: Metode Failure Mode and Effect Analysis (FMEA), Risk Priority Number (RPN), Stock Pile
Türkiye ve Hindistan İlkokul 4. Sınıf Matematik Dersi Öğretim Programlarının Program Öğeleri Bağlamında Karşılaştırılması
Authors: ERSÖZ Sevgi , ABALI ÖZTÜRK Yasemin , DEMİR Mehmet Kaan
Published: July 2023

ÖZ

Bu araştırmada Türkiye ilkokul 4. Sınıf Matematik Dersi Öğretim Programı ile Hindistan ilkokul 4. Sınıf Matematik Dersi Öğretim Programının hedef, içerik, eğitim durumu ve ölçme-değerlendirme ögeleri bağlamında karşılaştırması, benzerlik ve farklılıklarının ortaya konması amaçlanmıştır. Araştırma ülkeler-arası (cross-national) karşılaştırmalı eğitim araştırmasıdır, yatay yaklaşım ve tanımlayıcı yaklaşım birarada kullanılmıştır. Araştırmada veri toplama yöntemi olarak doküman incelemesi kullanılmış ve verilerin kaynağını Hindistan ve Türkiye’de uygulamada olan, ülkelerin resmi genel ağ siteleri ile ulaşılan ilkokul 4. Sınıf Matematik Dersi öğretim programları ve ders kitapları oluşturmaktadır. Araştırmada toplanan verilerin analizinde; betimsel analiz yönteminden yararlanılmıştır. Araştırmadan elde edilen bulgular doğrultusunda Türkiye’ye göre Hindistan’ın çok daha esnek öğretim programlarına sahip olduğu, Türkiye ilkokul 4. Sınıf Matematik Dersi Öğretim Programında Hindistan ilkokul 4. Sınıf Matematik Dersi Öğretim Programına göre daha çok teori, kavram ve tanımların öğrenilmesinin amaçlandığı, Hindistan ilkokul 4. Sınıf Matematik Dersi Öğretim Programının ise daha çok matematiğin pratik kullanımının geliştirilmesini amaçladığı vurgulanabilir. Bu farklılıkların yanısıra her iki öğretim programının da matematiğin günlük hayatta kullanımına önem verdiği, yapılandırmacı kurama dayanan öğrenmeyi öğrenme, yaparak-yaşayarak öğrenme anlayışlarına dayandığı da elde edilen sonuçlar arasındadır.

Anahtar Kelimeler: Karşılaştırmalı eğitim, ilkokul matematik öğretim programı, Türkiye eğitim sistemi, Hindistan eğitim sistemi
Treatment outcome of metastasis to the pituitary gland: a case series of 21 patients with pathological diagnosis
Authors: Hong Sukwoo , Atkinson John L. , Erickson Dana , Kizilbash Sani H. , Little Jason T. , Routman David M. , Van Gompel Jamie J.
Published: August 2023

OBJECTIVE

The aim of this study was to report the treatment course of histologically confirmed metastases to the pituitary gland (pituitary metastasis).

METHODS

The Mayo data explorer was used to find patients with pituitary metastasis. Twenty-one patients were identified between the years 2001 and 2021, and their data were retrospectively collected.

RESULTS

The most common primary cancer origin was lung in men (45%) and breast in women (33%). The median age was 66 years (IQR 56–68 years). Patients presented with headache (67% [14/21]), vision problems (86% [18/21]), anterior hypopituitarism (71% [15/21]), and arginine vasopressin deficiency (38% [8/21]). Pituitary metastases were found before the diagnosis of the primary cancer in 5 patients (24%). The mean ± SD tumor size was 2.0 ± 0.7 cm, and 90% (19/21) presented as a solitary pituitary mass with no other intracranial metastatic lesions. Common radiological features were pituitary stalk thickening (90% [19/21]), cavernous sinus involvement (71% [15/21]), and constriction at the diaphragma sellae (52% [11/21]). Transsphenoidal surgery was performed in 20 patients, and subtotal resection was most frequently attained (76% [16/21]). Fourteen patients (67%) had adjuvant radiation therapy, and 15 patients (71%) were treated with systemic therapy. The median time from surgery to the initiation of radiation therapy was 16 days (IQR 11–21 days), and that from surgery to the initiation of systemic therapy was 5.0 months (IQR 1.5–14 months). During management, headaches improved in 57% (8/14) and vision problems improved in 61% (11/18) of cases; new hypopituitarism occurred in 5 patients. Six patients developed recurrence, and the median progression-free survival was 24 months (95% CI 5.4–43 months). After recurrence, 1 patient with adenoid cystic carcinoma was treated with rescue radiotherapy twice, and 4 patients responded well to systemic therapy. The median overall survival (OS) was 25 months (95% CI 7.1–43 months). The mean OS was better in patients with neuroendocrine lung tumor (261 months) and papillary thyroid carcinoma (80 months) and worse in patients with small cell lung cancer (4 months) and unknown origin (5 months).

CONCLUSIONS

Surgery with or without adjuvant radiotherapy is effective for mass reduction, rapid symptomatic improvement of vision and headaches, and definitive diagnosis. Even after local tumor control failure, some patients still benefit from radiation and/or systemic therapy.
Prophylactic cranial irradiation effect on survival in patients with small cell lung cancer: a comprehensive systematic review and meta-analysis
Authors: Maroufi Seyed Farzad , Fallahi Mohammad Sadegh , Kankam Samuel Berchi , Sheehan Jason P.
Published: August 2023

OBJECTIVE

Prophylactic cranial irradiation (PCI) is a companion treatment option for small cell lung cancer (SCLC) patients. However, its efficacy and associated risk factors have not been clearly defined. In this study, the authors aimed to systematically assess the effectiveness and role of PCI in the treatment plan of SCLC.

METHODS

The PubMed, Scopus, Web of Science, and Cochrane databases were searched using the following key terms and their equivalents: "brain," "radiotherapy," "metastases," "prophylactic," and "small cell lung cancer." Studies comparing overall survival (OS), progression-free survival (PFS), brain metastasis–free survival (BMFS), and incidence of brain metastases between patients receiving PCI and those not receiving it were considered eligible. Risk of bias was assessed using the Risk of Bias in Non-Randomized Studies–of Interventions (ROBINS-I) tool. Meta-analysis was conducted on the mentioned outcomes with subgrouping based on different factors.

RESULTS

The authors identified 74 studies published between 1983 and 2022 with 31,551 SCLC patients, of whom 26.7% received PCI. The studies were a mix of prospective randomized and retrospective observational studies. Patients with limited-stage disease receiving PCI had better OS, PFS, and BMFS than those not receiving PCI. Patients receiving PCI also had significantly longer OS times and developed brain metastases significantly later. However, findings regarding extensive-stage SCLC were not as promising.

CONCLUSIONS

PCI is an effective option for limited-stage SCLC patients. It improves OS and PFS, delays brain metastases, and reduces the incidence of brain metastases. However, it might not benefit patients with extensive-stage SCLC under adequate follow-up with MRI surveillance. Finally, the heterogeneity of the included studies and publication bias were the main limitations of this study.
MR-guided focused ultrasound–induced blood-brain barrier opening for brain metastasis: a review
Authors: Grasso Giovanni , Torregrossa Fabio , Noto Manfredi , Bruno Eleonora , Feraco Paola , Buscemi Felice , Bartolotta Tommaso Vincenzo , Gagliardo Cesare
Published: August 2023

Although the therapeutic armamentarium for brain metastases (BMs) has been expanded from innovative surgical techniques and radiotherapy to include targeted therapies and immunotherapy, the prognosis of BMs remains poor. Despite the proven efficacy of numerous compounds in preclinical studies, the limited penetration of promising therapeutic agents across the blood-brain barrier (BBB) remains an unaddressed issue. Recently, low-intensity magnetic resonance–guided focused ultrasound (MRgFUS) in combination with microbubbles has been shown to overcome vascular and cellular transport barriers in the brain and tumor microenvironment, resulting in increased drug diffusion and preliminary effective results. Preclinical studies have investigated the increased penetration of many therapeutic agents including doxorubicin, trastuzumab, and ipilimumab into the CNS with promising results. Furthermore, anticancer drugs combined with MRgFUS-induced BBB opening have been demonstrated to improve animal survival and slow tumor progression. Accordingly, the first clinical trial has recently been launched and hopefully the results will provide evidence for the safety and efficacy of drug delivery enhanced by MRgFUS-induced BBB opening in BMs. This review aims to provide an overview of transcranial low-intensity MRgFUS application for BBB disruption and a comprehensive overview of the most relevant evidence in the treatment of BMs.
Two-stage radiosurgery for large brain metastases: a systematic review and meta-analysis of clinical outcomes
Authors: Terry Fernando , Merenzon Martin A. , Daggubati Lekhaj , Zullo Kyle , Levy Adam S. , Bhatia Shovan , Luther Evan , Komotar Ricardo J. , Shah Ashish H. , Ivan Michael E.
Published: August 2023

OBJECTIVE

Brain metastases (BMs) are the most common intracranial tumors. In several cases, they present as large masses, which are related to a worse prognosis and more complex therapeutic alternatives. Staged radiosurgery is reported to achieve local control with minimal radiation-related adverse events in BMs. However, no methodological consensus has been achieved in its use for large brain metastases (LBMs; > 2 cm). Therefore, the authors aimed to determine the effectiveness and safety of 2-stage Gamma Knife radiosurgery (GKRS) for LBMs, in order to optimize patients’ postoperative course.

METHODS

A systematic review of available literature was run in PubMed/MEDLINE, Scopus, Web of Science, Cochrane (OvidSP), and Google Scholar for works published up to December 14, 2022. Nonrandomized clinical trials, case series, and cohort studies were included. The risk of bias was assessed using the Risk of Bias in Nonrandomized Studies–of Interventions (ROBINS-I) and Joanna Briggs Institute tools. Pooled mean difference and rates estimates were calculated by a random-effects model meta-analysis. The degree of heterogeneity was expressed using the I2 statistic. A subgroup analysis was performed. Ultimately, the certainty of evidence was evaluated using the Grading of Recommendations Assessment, Development, and Evaluation (GRADE) assessment.

RESULTS

Fourteen studies met the eligibility criteria (cohorts, case series, and nonrandomized clinical trials), including 958 patients. A total pooled mean volume reduction of 6.27 cm3 (95% CI 5.67–6.88 cm3) and 54.36% (95% CI 39.92%–68.79%) after 2-stage GKRS was reported. Pooled rates of complete response (44.63%; 95% CI 26.50%–64.31%), neurological mortality (16.19%; 95% CI 7.68%–30.98%), and all-cause mortality (47.92%; 95% CI 28.04%–68.49%) were calculated. Overall certainty of evidence ranged from very low to moderate.

CONCLUSIONS

Two-stage GKRS is an effective and safe approach for the treatment of LBMs. Nevertheless, the lack of available literature and the weak methodological approaches used determine a low to very low certainty of evidence and cannot provide robust evidence to recommend this intervention. Therefore, it is necessary to conduct higher-quality primary studies.
Langerhans cell histiocytosis located in the spheno-orbital bone and the pons: illustrative case
Authors: Cekic Efecan , Karagoz Ahmet , Sakar Mustafa , Senay Rabia Emel , Akar Kadriye Ebru , Bozkurt Suheyla , Dagcinar Adnan
Published: August 2023

BACKGROUND

This is a case of aggressive Langerhans cell histiocytosis (LCH) with an atypical intracranial location.

OBSERVATIONS

In this report, the authors present the diagnosis and treatment of a 12-year-old male patient diagnosed with LCH. The patient was admitted to the emergency department with left-sided facial palsy, and a solid lesion with mass effect in the pons was found. A biopsy was performed via suboccipital craniotomy, and the diagnosis was LCH. A chemotherapy regimen was started since the LCH sample was the resistant type. The patient showed improvement in his neurological deficit following treatment.

LESSONS

This rare localized and aggressive case’s diagnosis process and treatment choices may apply to future cases.
Анатолій Васильович Козлов – український учений-літературознавець і педагог-новатор (до 85-річного ювілею професора Криворізького державного педагогічного інституту / університету) : біобібліографічний покажчик
Authors: Дікунова Олена , Кравченко Олена
Published: July 2023

Покажчик присвячено Анатолію Васильовичу Козлову – українському літературознавцю, доктору філологічних наук, професору Криворізького державного педагогічного інституту / університету. У покажчику репрезентовано бібліографію праць А. В. Козлова. Представлено наукові видання, підручники, навчальні посібники, публікації в збірниках наукових праць і матеріалах наукових конференцій та статті у фахових періодичних виданнях. У покажчику також подано матеріали про наукову й педагогічну діяльність професора А. В. Козлова. Покажчик адресовано літературознавцям, викладачам філологічних дисциплін закладів вищої освіти, аспірантам, здобувачам вищої освіти – майбутнім філологам з метою популяризації наукової спадщини А. В. Козлова.
Judges' Considerations In Implementing Criminal Sanctions To Persons Of The Crime For Forcing Children To Perform Abusive Actions (Decision Number: 150/Pid.Sus/2021/PN Gdt)
Authors: Adinata Muhammad Umar , S. Endang P  , Indah Satria
Published: July 2023

Abstract

One example of the crime of forcing a child to commit obscene acts is based on Decision Number: 150/Pid.Sus/2021/PN Gdt which states that the Defendant Nuzul Hairi Bin Nurul Huda has been legally and convincingly proven guilty of committing a crime of committing violence and threats of forceful violence child commits obscene acts. Factors that cause perpetrators to commit crimes of forcing children to commit obscene acts based on Decision Number: 150/Pid.Sus/2021/PN Gdt are educational factors, environmental factors or place of residence. The criminal act of sexual intercourse with a child in the jurisdiction of the Pesawaran Resort Police is indicated by the process of development of culture and civilization. Displacement of norms of behavior in western cultural areas and studied as a mental conflict or as a clash of cultural values. Economic factor theory is fundamental to all social structures. Economic development in the jurisdiction of the Pesawaran Resort Police tends to be uneven, there are still many people who have not found work or are unemployed. This condition causes social deviations in society, such as the crime of sexual intercourse with a child in the jurisdiction of the Pesawaran Resort Police. The judge's considerations in applying criminal sanctions to perpetrators of the crime of forcing children to commit obscene acts based on Decision Number: 150/Pid.Sus/2021/PN Gdt consist of 2 (two) things, namely aggravating things and mitigating things. What was aggravating was that the actions of the defendant had damaged the future of the witness-victim, the parents of the witness-victim felt very objection to the actions of the defendant, and the actions of the defendant had violated religious norms. Meanwhile, the mitigating factors are that the defendant admits and regrets his actions and promises not to repeat his actions, and the defendant has never been punished.
Criminological Analysis of Criminal Actions Motor Vehicle Theft Based Victimological Perspective (Decision Number: 168/Pid.B/2022/PN.Kla)
Authors: Bernaditya Albertus Hazel , Lukmanul Hakim  , Gindha Ansori Wayka
Published: July 2023

Criminology is the science that studies crime. Crime is an act that harms society so that a negative reaction is given to it. One of the crimes that often occurs in society is the crime of motor vehicle theft. It is said to be detrimental because of the crime of theft of a motorized vehicle whose target object is a motorized vehicle that has high mobility and has high economic value. While victimology is the study of victims. It is said as a victim because there are several factors that make people commit these crimes. The problems in this study are the factors that cause the crime of motor vehicle theft and legal protection for the perpetrators of theft who participate in helping the main perpetrators based on a victimological perspective. The results of this research and discussion show that the factors that cause the crime of motor vehicle theft are environmental and economic factors. This was due to an invitation from a friend of the defendant who invited him to commit the theft as well as economic factors due to the high level of poverty which made the defendant not hesitate to take part in the theft of motorized vehicles. As well as legal protection for the perpetrators of theft who participate in helping the main actors based on the perspective of victimology is to get justice as fair as possible because the defendant behaves well and surrenders himself to the authorities.
Legal Security Of Land Ownership By The System Law In Indonesia And Judicia Practice
Authors: Barita Sidabutar
Published: July 2023

Cases of land title certificates issued by the National Land Agency are still officially available in several regions in Indonesia. A certificate of ownership is a guarantee to provide legal certainty and protection to the holder of a right to a plot of land so that the party who proves is the true owner of the parcel of land. In this study, having proof of land ownership in the form of a Certificate of Ownership over land does not guarantee legal certainty for landowners. This study aims to determine the legal certainty of ownership of certificates of land rights based on several applicable laws and regulations, and based on the decision of the Medan District Court Number 784/Pdt.G/2019/PNMdn; Pekanbaru District Court decision Number 178/Pdt.G/2021/PNPbr; and Jambi District Court decision Number 40/Pdt.G/2021/PNJmb. The results of this study are that legal certainty of ownership of land rights according to the legal system in Indonesia does not provide absolute certainty of rights because even if someone already has a letter as proof of land ownership, other parties can still sue the owner of the land.
The Contradiction Of Diversion Become An Option For Handling And Resolving Cases Against Children Who Complete Criminal Actions
Authors: Retno Dwi Astuti  , Sitinjak Anggi Dwita Clara Afrilia , Yusabbihu Zafarina Sa`diah  , Surya Afif Rahmandika  , Herli Antoni
Published: July 2023

Diversion is a system of handling outside the formal justice system process due to criminal cases involving child perpetrators who are underage. Settlement through diversion is reserved for children in conflict with the law. This journal writing research method uses normative theory. Therefore, according to Article 108 of Law of the Republic of Indonesia Number 11 of 2012 concerning the Juvenile Criminal Justice System, the diversion system is used for reasons of distancing and separating underage perpetrators from settlement through the formal justice system so that discrimination does not occur against child offenders. Through prevention efforts in the form of diversion, it does not provide a deterrent effect so that underage criminals underestimate the existence of these diversion efforts. Efforts so that child victims are protected from children who commit acts against the law or perpetrators are maximally not giving diversion to children who return to committing crimes after a judge's decision.
Copyright And Music And Song Art Works In The Digital Era
Authors: Dwi Anindya Harimurti
Published: July 2023

In the last two decades, art and technology have become increasingly inseparable. Technology, in this case the internet, has given birth to a new era known as the digital era, followed by the emergence of many problems, one of which is in the field of copyright. A number of cases of copyright infringement were committed by art creators and the public in general, both consciously and unconsciously due to the lack of knowledge about copyright, especially now that all the information needed is readily available on the Internet. This condition provides a huge opportunity to plagiarize a work of art. Through library research, this study focuses on the perspective of limitations and exceptions to copyrights for works of art in the digital era and describes the concepts of regulation and protection.
Professional Competence Enhancement of High School Teachers	through Scientific Paper Writing Training
Authors: Rahim Fanny Rahmatina , Kher Dinovia Fannil , Harisman Yulianti
Published: August 2023

The study fulfils the gap in teachers' scientific paper writing skills, which benefits both the academic community and pupils. Teachers' competence can be improved so that they can engage in evidence-based practices, contribute to academics, and deliver engaging educational experiences that develop critical thinking in their pupils. Scientific paper writing training is critical for developing high school teachers' professional competency. The purpose of this study was to look into the efficiency of such training in improving teacher abilities and knowledge. A quantitative descriptive method was employed in the study to evaluate the efficiency of a scientific paper writing training programme for high school teachers. Data was gathered by assessing the quality of the teachers' papers using a quality assessment form. The data was analysed using statistical procedures such as the t-test and N-Gain analysis. The t-test compared pre- and post-treatment scores, while the N-Gain analysis assessed the training's effectiveness. These methodologies aided in determining the program's impact on teachers' writing skills and quantifying the level of development in their scientific paper writing competence. These data indicate the training program's effectiveness in improving teachers' understanding and skills in scientific paper writing. Training in scientific paper writing improves high school teachers' professional competency by increasing their understanding of article components, scholarly practices, and writing abilities. It emphasizes the importance of continuing professional growth and filling gaps in critical thinking and interdisciplinary writing.
Experiences of Student Teachers in Thailand: A Pre-service Teacher Training Encounter
Authors: Tique Rhoda
Published: July 2023

COVID-19 greatly impacted the lives of students in universities worldwide, more so for the students who are to take their last year of schooling and are about to enter their pre-service teacher training. Students who wished to become teachers before and even during the pandemic needed their pre-service teaching training or teaching internship. It can be done locally or abroad. This study aimed to explore the professional experiences of student teachers while having their pre-service teacher training and on-the-job training abroad. This study aimed to determine the future teachers' professional needs as demonstrated by the challenges experienced by these student teachers, especially in addressing the call of the global community. A qualitative design was used employing individual interviews of the nine (9) Student Teachers participants based on purposive sampling. Then, it was supported by a group interview after the first interview round. Through thematic analysis, the professional experiences of the student teachers were determined and analyzed. Results showed that the student teachers had unique professional experiences, such as dealing with the English level of students, multi-level classroom teaching experience, use of different strategies, professional development, learning the Thai Language, and use of good facilities. The student teachers also faced challenges along with their professional experiences. These are challenges related to the difficulty in teaching English, teaching in multi-level classes, teaching more than the expected class size, multiple co-curricular tasks, and difficulty in learning the Thai language. However, despite these challenges, the student teachers learned and improved themselves in their pre-service teacher training abroad. They managed to equip themselves to become fit regarding the call of Internationalization and Globalization through quality education.
Water Flow & Temperature Control to Increase Extraction Yield of Light-roasted Coffee Beans
Authors: Hutagalung Samuel
Published: July 2023

Using light-roasted coffee beans for brewing espresso poses a general problem for pump-based espresso machines. Soluble in light-roasted coffee beans is more challenging to extract and requires a higher EY percentage because it has a relatively higher acidity level than dark-roasted coffee beans. The extraction range of 18% - 22% in light-roasted coffee beans for espresso brewing with an 8% - 12% TDS is qualitatively considered insufficient to produce espresso with a balanced taste. To improve the extraction ability of the espresso machine on coffee soluble. We design two features that hypothetically can solve the problem: Temperature Control Module to increase water temperature stability as a replacement for the thermostat, and Flow Control Module to regulate the speed of the vibration pump by adjusting the voltage resistance to reduce the water pressure/ flow rate used during the initial extraction at the preinfusion phase. Based on the results of trials using an espresso machine that has added temperature and flow control modules, there is an increase in the average percentage of extraction compared to the results of trials using stock machines; the average extraction percentage increased by 4.83 points. Qualitatively, this increase of %EY also significantly impacts the espresso taste, which tasted very sour and unbalanced, became relatively more balanced and comfortable to enjoy.