bluuebunny/crossref_metadata_2025 huggingface dataset:
ОСНОВНІ ЗАСАДИ ВПРОВАДЖЕННЯ МОДЕЛІ «ЗЕЛЕНОЇ» ЕКОНОМІКИ В УКРАЇНІ
Authors: Фісуненко П.А.
Published: April 2024

Концептуальні зрушення парадигми функціонування економічної системи країни, в умовах повномасштабного воєнного вторгнення, зумовлюють необхідність докорінної зміни стратегічних векторів прогресивного розвитку «зеленої» економіки держави, акцентуючи увагу на трансформаційних зрушеннях та необхідності диверсифікації ступеню впливу потенційних зовнішньоекономічних загроз. Функціонування існуючої моделі «зеленої» економіки в таких умовах є малоефективним, а тому, - необхідними є структурні зміни парадигми становлення «зелених» інвестицій в державі, залучення додаткового фінансування державних проєктів та програм у сфері «зеленої» економіки, необхідності зміни інноватики програми стратегічного розвитку економічної системи в цілому. У статті проаналізовано основні засади впровадження комплексної моделі «зеленої» економіки в Україні та забезпечення аспектів її прогресивного розвитку. Наукова новизна дослідження полягає у проведенні комплексного аналізу пріоритетних аспектів інноваційної моделі «зеленої» економіки із врахуванням ступеню впливу факторів оточуючого економічного середовища.
Transportando el poder:
los palanquines en el Clásico maya
Authors: Romero Sandoval Roberto , Esparza Olguín Octavio Quetzalcóatl , Mumary Farto Pablo Alberto
Published: April 2024

En las vasijas tipo códice del periodo Clásico Tardío (600
a 900 d. C.), así como en diferentes tipos de monumentos,
existen representaciones de tronos portátiles en escenas
palaciegas que fueron utilizados como vehículos
para llevar al soberano a diferentes lugares del señorío,
o fuera de sus fronteras, con el fin de supervisar actividades
rituales, militares y diplomáticas, entre otras. En
este sentido, el objetivo del presente trabajo será analizar
las distintas representaciones de palanquines en el
arte maya, así como destacar su mención en los textos
jeroglíficos del Clásico maya, donde se asocian con el vocablo
piit, ‘litera, palanquín’.
In the codex-type vessels of the Late Classic period (600
to 900 AD), as well as in different types of monuments,
there are representations of portable thrones in palace
scenes that were used as vehicles to carry the sacred
ruler to different places in the kingdom, or outside its
borders, in ordert to supervise ritual, military, and diplomatic
activities, among others. In this sense, the objective
of the present paper will be to analyze the different
representations of palanquins in Mayan art, as well as
highlight their mention in the hieroglyphic texts of the
Classic Maya, where they are associated with the word
piit, “litter, palanquin.”
Mennyiben befolyásolja a jogi személyiség elméletét a közkereseti és a betéti társaság jogi személlyé nyilvánítása az új magyar Polgári Törvénykönyvben?
Authors: Prugberger Tamás
Published: April 2024

A tanulmány felvázolja a magyar társasági jogban 2013-ban az új Polgári Törvénykönyv által hozott jelentős változást, amely jogi személyiséget biztosít minden gazdasági társaságnak, tehát a közkereseti és a betéti társaságnak is, eltérve a korábbi német-osztrák elméleti megközelítéstől. A nyugat-európai jogban a betéti társaság és a tőkés társaság közötti különbségtétel a társasági méretre támaszkodik. Magyarország kiterjesztette a jogi személyiséget a közkereseti és a betéti társaságokra, igazodva a nyugat-európai gyakorlathoz. A Kft. és Bt. jogi státusza azonban továbbra is ellentmondásos, ami a gazdasági társaságok abszolút jogi személyiség fogalmának újraértékelésére késztet, tekintettel a fejlődő gyakorlatra. A szöveg ezt a német, angolszász és francia jogi keretekkel összehasonlítva vizsgálja.
Digital Narratives for Academic Success: Enhancing Student Achievement through Storytelling
Authors: Tamimi Murad A. Ahmed , Elahi Ehsan , Ramadan Jehad A.
Published: April 2024

This study looked at how Digital Story-telling (DST) affected high school students studying English as a second language in terms of their learning motivationm, critical thinking, and academic achievement. This year-long study included 48 10th-grade students from two English courses using a quasi-experimental design with pretest and posttest assessments. Information technology-integrated instruction at two levels—lecture-style (for the comparison group) and DST (for the experimental group)—was the independent variable. In order to assess how well DST improves learning outcomes, both quantitative and qualitative data were gathered. This included critical thinking and English language competence tests as well as questionnaire answers about learning motivation. The collected data underwent examination through descriptive analysis, analysis of covariance (ANCOVA), multivariate analysis of covariance (MANCOVA), and qualitative content analysis. Our findings show that participants in the DST group surpassed those in the lecture-style ITII group concerning critical thinking, learning motivation, and English proficiency. Insights gathered from interviews underscore the noteworthy educational impact of DST. Both the teacher and students expressed that DST elevated their understanding of course content, heightened their curiosity, and enhanced their critical thinking abilities—essential skills for equipping students for the dynamic challenges of the 21st century. Incorporating stories from Palestinian culture, rooted in the real-life experiences of students, has been successfully undertaken to enhance the cultural relevance of DST. This addition brings a valuable dimension to the research, providing a more comprehensive understanding of how DST impacts students' learning experiences. By integrating these authentic narratives, the study successfully captures the cultural richness and diversity inherent in the students' backgrounds, thereby enriching the overall research findings.
PARECERISTAS DE 2018
Authors: Equipe Editorial
Published: April 2024

Relação dos pareceristas externos do ano de 2018.
PARECERISTAS DE 2022
Authors: Equipe Editorial
Published: April 2024

Relação dos pareceristas externos do ano de 2022.
PARECERISTAS DE 2023
Authors: Equipe Editorial
Published: April 2024

Relação dos pareceristas externos do ano de 2023.
Effects of Globalization on Labor Standards and Working Conditions
Authors: Uwadinma Alex Iloba
Published: April 2024

The effects of globalization on labor standards and working conditions have been widely debated, with some arguing that globalization has improved labor standards and working conditions while others claim it has led to a deterioration of such standards. This paper aims to explore the effects of globalization on labor standards and working conditions. The study will examine the impact of globalization on the labor market, focusing on changes in labor laws and regulations, worker rights, and wages. The research will also investigate the impact of globalization on working conditions, including workplace safety and health, and the quality of jobs. Furthermore, the study will explore the role of multinational corporations in shaping labor standards and working conditions in different countries. The findings of this research will provide insights into the impact of globalization on labor standards and working conditions and will contribute to the ongoing debate on the implications of globalization for the labor market.

Dhaka University Law Journal, 2023, 34 (2), 133-151
Comparison between tubularisation of an intact and laterally augmented urethral plate urethroplasty and tubularised incised plate (TIP) urethroplasty for hypospadias repair
Authors: Shaheen Saifuddin , Biswas Ipsita , Alam Muhammad Rashedul
Published: April 2024

Objectives: The aim of this study was to compare the outcome of hypospadias repair by tubularisation of an intact and laterally augmented urethral plate urethroplasty and TIP urethroplasty. Methods: This prospective comparative study was conducted from July 2018 to January 2020 and included 35 patients with primary distal and mid penile hypospadias. All had urethral plate widths of 8–10 mm. Exclusion criteria were mega meatus intact prepuce, previous repair, circumcision, urethral plate of >10 mm or <8 mm in diameter, chordee >30°. In Group A underwent tubularisation of an intact and laterally augmented urethral plate urethroplasty and in Group B underwent tubularised incised-plate (TIP) urethroplasty. The follow up period was 06 months. Results: The success rate without any complication was 88.89% and 76.48% in Group A and B respectively. Meatal stenosis occurred 0% and 11.76% in Group A and B respectively. Wound dehiscence rate was 5.55% and 5.88% in Group A and B respectively. Urethrocutaneous fistula occurred 5.55% and 5.88% in Group A versus Group B. Overall complication occurred 11.11 in Group A and 23.52% in Group B. Conclusion: The outcome of tubularisation of intact and laterally augmented urethral plate urethroplasty was better than TIP urethroplasty.
Journal of Paediatric Surgeons of Bangladesh (2019) Vol. 10 (1 & 2): 32-36
HIV/AIDS Care and Support Services Satisfaction for Orphan and Vulnerable Children in Northwest Ethiopia: Mixed Method Study
Authors: Asmare Lakew , Yigzaw Zeamanuel , Alemu Tihtna
Published: April 2024

Background: The provision of comprehensive care and support services to orphans and disadvantaged children that are individualized and tailored through the use of child- and family-centered information is critical but little if any information is available on satisfaction with HIV/AIDS care among orphans and vulnerable children in Gondar. Therefore, this study aimed to assess the satisfaction of HIV/AIDS care and support service delivered to caregivers of Orphans and Vulnerable Children, Gondar City, 2023.

Methods: A facility-based cross-sectional study design with explanatory concurrent mixed methods was applied. A total of 424 Orphans and Vulnerable Children’s caregivers for interviewer-administered questionaries, 5 key informant interviews, and 385 Orphans and Vulnerable Children’s document reviews were conducted. The data were entered into the Kobo toolbox software and exported to STATA version 16 for analysis. A binary logistic regression analysis was performed to identify significant variables. The qualitative data were transcribed, translated, coded, and analyzed using thematic analysis.

Results: In this study, the Orphans and Vulnerable Children’s/ caregivers satisfaction of HIV/AIDS C&S services was 68.20% with (95%CI=63.20%,71.10%). In multivariable logistic regression analysis, separate waiting rooms (AOR=0.05, 95% CI: 0.005, 0.52), materials for Orphans and Vulnerable Children to take home (AOR=1.76, 95%CI: 1.67, 7.59), and provisions of attractive and friendly services to Orphans and Vulnerable Children (AOR=2.24, 95%CI: 1.08, 4.64) were significant variables.

Conclusion: Orphan and vulnerable children caregiver satisfaction to HIV/AIDS C&S service was 68.20% with (95%CI=63.20%,71.10%). Separate waiting rooms, attractive and friendly service, and materials to take home were factors that affected Orphans and Vulnerable Children’s caregiver satisfaction to the HIV/AIDS C&S service. Rigorous efforts to build systems that apply the policy and principles of HIV C&S services are recommended. Therefore, the government, partners, programmers, and implementers should give attention to improving the HIV C&S services.
Lysimetric studies at the Federal Williams research center of forage production and agroecology turned 50 years old
Authors: Grechishnikov Nikolay , Trofimov Ilya
Published: April 2024

The study of ecosystems, biological and ecological features of perennial grasses, soils, groundwater and monitoring of their dynamics are impossible without lysimetric studies. Lysimeters serve as a reliable means of studying and managing agroecosystems and the entire complex of plant development factors. At the All-Union Williams feed research Institute, lysimetric studies on the study, regulation and forecasting of water, food and thermal regimes of reclaimed natural forage lands in the agroecosystem "soil — plant — infiltration runoff" on irrigated pastures in the conditions of the Central District of the Non-Chernozem zone (Moscow region) were started at the Lysimetric Station built in 1972. The station includes a laboratory building, a tunnel room with a depth of about 3 m and a length of more than 40 m, a hardware room, lysimetric devices and installations of a special design. The lysimetric installation allows you to jointly study the water balance, the balance of chemicals and automate the observation processes. The developed design of the measuring equipment increased the accuracy of the experiment, and due to its small dimensions, it allowed experiments to significantly expand the range of studied groundwater depths (from 0.75 m to 2 m). Lysimeters of 2 types (for water balance and agrochemical studies) are designed for year-round observations. The results of lysimetric studies are extrapolated to areas with similar environmental conditions.
Komparasi Metode Isolasi DNA dalam Mendeteksi Gen toxR Bakteri Vibrio parahaemolyticus pada Udang Vaname (Litopenaeus vannamei)
Authors: Lestari Nana
Published: April 2024

Vibrio parahaemolyticus bacteria is one of the dangerous pathogens in vaname shrimp farming (Litopenaeus vannamei). Infection with this bacterium can cause mass mortality in shrimp and considerable losses for farmers. This bacterium also has a specific gene, the toxR gene, which is used to detect its presence. The successful detection of this bacterium determines the success of handling the disease it causes. The purpose of the study was to determine the optimal DNA isolation method in detecting the toxR gene of Vibrio parahaemolyticus bacteria in vaname shrimp. The research was conducted by means of molecular biology-based identification using two DNA isolation protocols, namely Chloroform and Boilling lysis buffer. Visualization results showed that toxR gene DNA appeared in samples isolated with Boiling Lysis Buffer in Tryptic Soy Broth (TSB) media culture preparation. This means that the boiling lysis buffer method is a suitable DNA isolation method for detecting the toxR gene of the Vibrio parahaemolyticus bacteria in white shrimp.
POLIGAMI DALAM KAJIAN SAD DZARI’AH
Authors: Idrus Idrus , Fuadi Shifriyan
Published: April 2024

Basically in a marriage a man can only have one wife. A woman can only have one husband. Law number 1 of 1974 concerning marriage and the Compilation of Islamic Law provides an opportunity if the male party wishes to have more than one wife, the Court can give permission to a husband who wishes to have more than one wife if the parties wish to do so. One of the objectives of Islamic law is to create benefit and avoid damage (mafsadah). If an action that has not been committed is strongly suspected to cause damage (mafsadah), then things that lead to the action are prohibited. This legal method became known as Sad Zari'ah. The permissibility of polygamy contained in the Marriage Law indirectly, this rule has implemented the concept of sad dzari'ah, because sad dzari'ah itself (generic meaning: closing the road) is preventing an act from causing mafsadah (damage). if an intermediary will cause mafsadah. So the prevention of mafsadah is carried out, because it is forbidden. This is solely for the sake of benefit and rejecting mafsadah (damage) for all citizens in general, and for husband and wife in particular.
MEMBANGUN INKLUSIFITAS BERAGAMA MELALUI LITERASI DIGITAL DI MA’HAD ALY
Authors: Dakir Dakir , Zubaidi Ahmad , Hasanah Nur Silfiatun
Published: April 2024

The research aims to analyze and understand the efforts made by Ma'had Aly Nurul Jadid Paiton Probolinggo in building religious inclusiveness through digital literacy for the academic community. This study uses a qualitative approach to the type of phenomenology, in which the researcher tries to understand the phenomena that occur and develop. Data collection techniques are carried out through participant observation, interviews and documentation. The data analysis was carried out through the stages of presenting data, reducing data and drawing conclusions. The results showed that digital literacy carried out by Ma'had Aly Nurul Jadid Paiton Probolinggo in building religious inclusiveness was carried out through the utilization of digital books, scientific halaqoh, online recitation and virtual knowledge sharing.
PERKEMBANGAN PONDOK PESANTREN AL-FATAH LAHAT DALAM BINGKAI SEJARAH 2007-2015
Authors: Hafidhuddin Hafidhuddin , Syahputra Muhammad Candra
Published: April 2024

Pesantren as the oldest Islamic educational institution in the archipelago is a place for the regeneration of ulama carried out by propagators of Islam to the indigenous population. Pesantren from its inception until now has been able to survive even though in its long journey it has faced many dynamics of changing times. The Pesantren  Al-Fatah Lahat is an Islamic boarding school located in Lahat Regency, South Sumatra Province, founded by Kyai H. Ramlan Fauzi bin H. Hasanuddin bin H. Husein bin Delames bin Reseh bin Rijal Penghulu bin Magdum on December 6, 2007 M., to coincide with the 26th Dzul-qa'dah 1428 H. This article is the first article to examine the development and teaching of the Pesantren Al-Fatah Lahat, which is a historical analysis from 2007 to 2015. This pesantren is located in the middle of a heterogeneous urban community life and is a pesantren with a comprehensive typology that combines traditional and modern teaching systems. The method used in this research is the historical method. At first (2007) Pesantren Al-Fatah Lahat prioritized the Qur’an with all aspects of its knowledge. Then established a formal education level MTs. The development of Al-Fatah in 2011 began to be recognized by MTs Al-Fatah around the Lahat district over time until 2015 this pesantren was not only students from the Lahat area, there were also from various areas outside the Lahat district.
NILAI-NILAI PENDIDIKAN TAUHID PERSPEKTIF SYEKH AHMAD AL-MARZUKI DALAM KITAB AQIDATUL AWAM
Authors: Sari Susi Siviana , Alfatah Akhid Ilyas
Published: April 2024

This research focuses on the Values of Tawhid Education. This study aims to find out how the education of monotheism according to Sayid Ahmad Al-Marzuki in the Aqidatul Awam book. Tawhid is the essential teaching because it contains instructions about the recognition of the oneness of Allah SWT as a consequence and pure existence and is a foundation and principle as a place for all deeds, and in essence, is to form a monotheistic human being. This research is library research, which focuses on discussing literature related to the focus of research, such as books that can be used as a reference source. In the results of this study, researchers found the value of monotheism education in Sheikh Ahmad Al-Marzuki that faith education consists of faith in Allah, Angels, books, Apostles, the last day, and qadha and qadar. The value of monotheism education is also closely related to Allah SWT, oneself, and fellow human beings.
Indigenous Islam and Puritan Islam in Indonesia through Nasr Hamid Abu Zayd's Hermeneutic Studies
Authors: Soedrajad Mochammad Rijaal , Tohir Naupal Asnawi
Published: April 2024

This paper studies the essence of Islam in the discourse of  Puritan Islam and Indigenous Islam in Indonesia. The Muslim community in Indonesia is now fragmented into two distinct groups. The first group considers that the essence of Islam must follow Middle Eastern traditions in all its aspects. The second group considers that the essence of Islam must adapt to local traditions/cultures as long as it does not conflict with the holy text of the Qur'anQur'an and Sunnah of Muhammad SAW. The purpose of this research is to explore what the essence of Islam in Indonesia should be. The method used in this paper is a literature study through Nasr Hamid  Abu Zayd's hermeneutic approach with his ideas related to the reading of the Qur'an through the historical context and criticism of Quranic verses. The results of the study indicate that the essence of Indonesian Islam is Indigenous Islam because Islam should be able to synergize with all times and places and thus be able to have a dialectic with the plurality of culture and society so that Islam can be accepted by all, including Indonesian cultures that is different from the Middle Eastern culture.
PENGEMBANGAN EKONOMI PESANTREN BERBASIS KEARIFAN LOKAL
Authors: Riadi Luthfi , Febrianto Achmad , Saifuddin Saifuddin
Published: April 2024

This study discusses the economic development of Islamic boarding schools in Probolinggo Regency by empowering coastal Muslim communities by producing marine processed products. Islamic boarding schools have provided a new nuance for coastal communities in the form of economic improvement. The researcher uses a qualitative phenomenological method with data collection techniques, namely observation and interviews and several references obtained from reputable books and journals related to empowerment and economic development. The results showed that; 1) The efforts made by the Nurul Jadid Islamic Boarding School in formulating a pattern of empowering coastal communities are based on two approaches, namely increasing the ability of the community independently and creating opportunities for economic development for the community; 2) Economic development of coastal communities is carried out through strengthening the social structure, economic equity, education on the values of economic independence, community participation, and community involvement in regional development.
Fostering Islamic Education: Embracing Multicultural Islamic Religious Education Values
Authors: Qornain Dzul , Sugiono Sugiono , Hakim Lukman , Rizquha Ach
Published: April 2024

This study aims to discuss the development of Islamic education by implementing the values of multicultural Islamic Religious Education in Madrasah. In order to obtain data from research results, research was carried out with a qualitative approach and this type of case study research. This research was conducted at MI Ihyaul Islam Pajarakan. Data collection techniques with participant observation, in-depth interviews, and documentation. The data collection technique uses the snowball sampling technique. The data sources used are primary and secondary. At the same time, the data analysis technique uses the Miles and Huberman model. The results of this study indicate that multicultural Islamic education is a response to the development of population diversity in Islamic educational institutions themselves, as well as demands for equal rights for each group. In broad terms, all students, regardless of their groups, such as gender, ethnicity, race, culture, social and religious strata, have the right to receive the same education. The implementation of the values of multicultural Islamic Religious Education in the development of Islamic educational institutions includes institutional aspects, curriculum aspects, and workforce aspects.
Nilai-Nilai Pendidikan Islam Ahlus Sunnah wal Jamaah (Aswaja) dalam Kumpulan Cerpen Santri Bejo Menantu Kyai
Authors: Sofyaningrum Rosita , Maulana Ahmad Irham
Published: April 2024

This research aims is to analyse and identify the values of Islamic Education of Ahlus Sunnah wal Jamaah (Aswaja) contained in a collection of short stories entitled Santri Bejo Menantu Kyai. The research method used in this research is a qualitative descriptive method with an interpretative approach. The data used in this research are written data in the form of quotation from the short stories related to the characteristics of Ahlus Sunnah wal Jamaah in the collection of short stories entitled Santri Bejo Menantu Kyai. The data source on this research is the collection of short stories entitled Santri Bejo Menantu Kyai. The data collection technique used in this research is the read- and- note technique. The data analysis technique employs a character approach by examining the content and implied purposes within the literary work, interoperating the values of Ahlus Sunnah wal Jamaah. The research findings indicates that the values of Ahlus Sunnah wal Jamaah in the collection of short stories entitled Santri Bejo Menantu Kyai encompass five attitudes. These attitudes are i’tidal which means take the truth path, tasawuth which means acting justly and to strike a balance; tawazun which means maintaining balance in actions (by doing deliberation); tasamuh which means having tolerance, mutual respect, and appreciate differences; amar ma’ruf nahi munkar which means enjoining what is good and forbidding what is evil.
Strengthening Inclusive Islamic Education: Building Islamic Boarding School-Based Foundations
Authors: Maula Nikmatul , Jazilurrahman Jazilurrahman , Suhermanto Suhermanto
Published: April 2024

This study aims to describe how to strengthen Islamic boarding school-based inclusive education at the Subulus Salam Islamic boarding school Pajarakan Probolinggo. In order to obtain data from research results, researchers used a qualitative case type approach. This research was conducted at the Subulus Salam Islamic boarding school. Data collection techniques with participant observation, in-depth interviews and documentation. While the data analysis technique uses the Spradley model with four types of analysis, namely domain analysis, taxonomic analysis, component analysis, and theme analysis. The results of this study indicate that the strategies undertaken to strengthen inclusive Islamic education based on Islamic boarding schools at the Subulus Salam Islamic boarding school are inclusive Islamic education policies, development of inclusive Islamic education curricula, integration of inclusive values through learning in schools, internalization of inclusive values through religious activities. and social, Kiai's exemplary role model.
Dynamics of Salafiyah Islamic Boarding Schools: Enhancing Religious Identity and Fostering Independence
Authors: Rifa Moh
Published: April 2024

This study aims to analyze the efforts of the salaf Islamic boarding schools and their implications in strengthening identity at the Nurul Qadim Islamic boarding school, Probolinggo, East Java. This study uses a qualitative approach to the type of case study. Data collection techniques in this study used three techniques, namely: participant observation, in-depth interviews, and documentation. Data analysis was carried out using data reduction, data display, and conclusion drawing/verification. The research results show that; The efforts of the salaf Islamic boarding schools to strengthen identity at the Nurul Qadim Islamic boarding school are carried out by means of; strengthens its salafi identity, is not affected by the dynamics of the times, has its own curriculum, builds the image of the institution, and is not old-fashioned. The implications of strengthening the religion and independence of Islamic boarding schools for the identity of the Nurul Qadim Islamic boarding school are curriculum reconstruction, strengthening the concept of Islamic values, strengthening partnerships and strengthening work ethics.
Deciphering the role of CX3CL1-CX3CR1 in aortic aneurysm pathogenesis: insights from Mendelian randomization and transcriptomic analyses
Authors: Qian Xingyu , Zheng Yidan , Xu Li , Liu Zongtao , Chen Ming , Tong Fuqiang , Fan Pengning , Chen Zhe , Dong Nianguo , Zhang Chao , Liu Junwei
Published: April 2024

Background

The crucial role of inflammation in aortic aneurysm (AA) is gaining prominence, while there is still a lack of key cytokines or targets for effective clinical translation.

Methods

Mendelian randomization (MR) analysis was performed to identify the causal relationship between 91 circulating inflammatory proteins and AA and between 731 immune traits and AA. Bulk RNA sequencing data was utilized to demonstrate the expression profile of the paired ligand-receptor. Gene enrichment analysis, Immune infiltration, and correlation analysis were employed to deduce the potential role of CX3CR1. We used single-cell RNA sequencing data to pinpoint the localization of CX3CL1 and CX3CR1, which was further validated by multiplex immunofluorescence staining. Cellchat analysis was utilized to infer the CX3C signaling pathway. Trajectory analysis and the Cytosig database were exploited to determine the downstream effect of CX3CL1-CX3CR1.

Results

We identified 4 candidates (FGF5, CX3CL1, IL20RA, and SCF) in multiple two-sample MR analyses. Subsequent analysis of the expression profile of the paired receptor revealed the significant upregulation of CX3CR1 in AA and its positive correlation with pro-inflammatory macrophages. Two sample MR between immune cell traits and AA demonstrated the potential causality between intermediate monocytes and AA. We finally deciphered in single-cell sequencing data that CX3CL1 sent by endothelial cells (ECs) acted on CX3CR1 of intermediated monocytes, leading to its recruitment and pro-inflammatory responses.

Conclusion

Our study presented a genetic insight into the pathogenetic role of CX3CL1-CX3CR1 in AA, and further deciphered the CX3C signaling pathway between ECs and intermediate monocytes.
Positive association between insulin resistance and fatty liver disease in psoriasis: evidence from a cross-sectional study
Authors: Zhong Xiaoyuan , Huang Dawei , Chen Rongfen , Yao Lingling , Ma Rui , Yu Yingyuan , Jiang Yuxiong , Kong Luyang , Lu Jiajing , Li Ying , Shi Yuling
Published: April 2024

Background

Fatty liver disease (FLD) is a common comorbidity of psoriasis and is often referred to as non-alcoholic fatty liver disease (NAFLD). However, the role of inflammation or insulin resistance (IR) in FLD is inconclusive. The study aims to explore whether FLD in psoriasis patients is more related to insulin resistance or systemic inflammation level.

Methods

Data for this study were collected from the Shanghai Psoriasis Effectiveness Evaluation Cohort, a prospective cohort that examines psoriasis characteristics in the Chinese population. IR was assessed using the triglyceride glucose (TyG) and TyG-body mass index (TyG-BMI) indicators. Systemic non-specific inflammation was assessed using the neutrophil-to-lymphocyte ratio (NLR), derived neutrophil-to-lymphocyte ratio (dNLR), and systemic immune inflammation index (SII).

Results

The analysis included a total of 647 patients. Subsequent logistic regression analysis revealed that NLR, dNLR, and SII were not significantly associated with FLD in psoriasis patients, while TyG and TyG-BMI showed significant associations with FLD. Subgroup analysis indicated that in the majority of subgroups, TyG and TyG-BMI were significantly associated with FLD, particularly TyG-BMI. Excluding individuals with methotrexate and acitretin resulted in consistent findings with the main analysis. Further analysis revealed a significantly higher diagnosis rate of metabolic-associated fatty liver disease (MAFLD) compared to NAFLD.

Conclusions

Metabolic factors play a crucial role in FLD in patients with psoriasis, and TyG and TyG-BMI are potential predictors of FLD. Therefore, MAFLD can be recommend as a term to describe FLD in psoriasis patients.

Trial registration

https://www.chictr.org.cn/showproj.html?proj=58256, identifier ChiCTR2000036186. A multi-center clinical study of systemic treatment strategies for psoriasis in Chinese population. Registered 31 August 2020.
Where the wild things aren’t: exploring the utility of rapid, small-scale translocations to improve site selection for shellfish restoration
Authors: Alder Al , Hillman Jenny R.
Published: April 2024

The assessment of site suitability is a crucial step for informing future successful species reintroductions. It ensures that translocated species have the highest chance of survival in their new environment while minimising ecological risks. However, it can be challenging when risk factors are unknown, especially when working with sessile species that cannot easily relocate to more favourable conditions. Under these scenarios, rapid (1-2 week-long), small-scale (< 1 m2) experimental translocations can help reduce uncertainty and improve restoration outcomes. This study conducted small-scale experimental translocations of green-lipped mussels, Perna canaliculus, to 11 shallow coastal sites spread across Tīkapa Moana/the Hauraki Gulf, Aotearoa/New Zealand to investigate the relationship between predator abundance, environmental factors, and mussel loss to help refine existing site selection criteria. The total number of known mussel predators counted from timelapse images was used as a proxy for potential predator pressure. Translocated mussel survival ranged from 10 - 99% and was best predicted by current speed, wind direction, predator abundance, water clarity, and depth (adjusted R2 = 0.505). Predator abundance was best explained by site location (p = 0.001) and had weak correlations among environmental parameters (Rho = 0.067). These results suggest that small, short-term (1-2 week) experimental translocations can help to refine site selection criteria and reduce uncertainty in the site-selection process for larger-scale shellfish reintroduction efforts with unknown and/or hard-to-control risk factors.
Cell-type specific inhibitory plasticity in subicular pyramidal cells
Authors: Guinet Alix , Grosser Sabine , Özbay Duru , Behr Joachim , Vida Imre
Published: April 2024

The balance between excitation and inhibition is essential to the proper function of cortical circuits. To maintain this balance during dynamic network activity, modulation of the strength of inhibitory synapses is a central requirement. In this study, we aimed to characterize perisomatic inhibition and its plasticity onto pyramidal cells (PCs) in the subiculum, the main output region of the hippocampus. We performed whole-cell patch-clamp recordings from the two main functional PC types, burst (BS) and regular spiking (RS) neurons in acute rat hippocampal slices and applied two different extracellular high-frequency stimulation paradigms: non-associative (presynaptic stimulation only) and associative stimulation (concurrent pre-and postsynaptic stimulation) to induce plasticity. Our results revealed cell type-specific differences in the expression of inhibitory plasticity depending on the induction paradigm: While associative stimulation caused robust inhibitory plasticity in both cell types, non-associative stimulation produced long-term potentiation in RS, but not in BS PCs. Analysis of paired-pulse ratio, variance of IPSPs, and postsynaptic Ca2+ buffering indicated a dominant postsynaptic calcium-dependent signaling and expression of inhibitory plasticity in both PC types. This divergence in inhibitory plasticity complements a stronger inhibition and a higher intrinsic excitability in RS as compared to BS neurons, suggesting differential involvement of the two PC types during network activation and information processing in the subiculum.
Efficacy of endovascular therapy for cerebral vasospasm following aneurysmal subarachnoid hemorrhage: a systematic review and meta-analysis
Authors: Ma Yu-Hu , Shang Rui , Li Si-Hao , Wang Ting , Lin Sen , Zhang Chang-Wei
Published: April 2024

Background

Cerebral vasospasm (CV) is a common complication of aneurysmal subarachnoid hemorrhage (aSAH), leading to increased morbidity and mortality rates. Endovascular therapy, particularly intra-arterial vasodilator infusion (IAVI), has emerged as a potential alternative treatment for CV.

Methods

A systematic review and meta-analysis were conducted to compare the efficacy of endovascular therapy with standard treatment in patients with CV following aSAH. The primary outcomes assessed were in-hospital mortality, discharge favorable outcome, and follow-up favorable outcome. Secondary outcomes included major infarction on CT, ICU stay duration, and total hospital stay.

Results

Regarding our primary outcomes of interest, patients undergoing intervention exhibited a significantly lower in-hospital mortality compared to the standard treatment group, with the intervention group having only half the mortality risk (RR = 0.49, 95% CI [0.29, 0.83], p = 0.008). However, there were no significant differences between the two groups in terms of discharge favorable outcome (RR = 0.99, 95% CI [0.68, 1.45], p = 0.963) and follow-up favorable outcome (RR = 1.09, 95% CI [0.86, 1.39], p = 0.485). Additionally, there was no significant difference in major infarction rates (RR = 0.79, 95% CI [0.34, 1.84], p = 0.588). It is important to note that patients undergoing endovascular treatment experienced longer stays in the ICU (MD = 6.07, 95% CI [1.03, 11.12], p = 0.018) and extended hospitalization (MD = 5.6, 95% CI [3.63, 7.56], p < 0.001). Subgroup analyses based on the mode of endovascular treatment further supported the benefits of IAVI in lowering in-hospital mortality (RR = 0.5, 95% CI [0.27, 0.91], p = 0.023).

Conclusion

Endovascular therapy, particularly IAVI, holds promising potential in reducing in-hospital mortality for patients with CV following aSAH. However, it did not show significant improvement in long-term prognosis and functional recovery. Further research with larger sample sizes and randomized controlled trials is necessary to validate these findings and optimize the treatment strategy for cerebral vasospasm in aSAH patients.

Systematic Review Registration

https://www.crd.york.ac.uk/PROSPERO/, identifier: CRD42023451741.
Brain MRI sequence and view plane identification using deep learning
Authors: Ali Syed Saad Azhar
Published: April 2024

Brain magnetic resonance imaging (MRI) scans are available in a wide variety of sequences, view planes, and magnet strengths. A necessary preprocessing step for any automated diagnosis is to identify the MRI sequence, view plane, and magnet strength of the acquired image. Automatic identification of the MRI sequence can be useful in labeling massive online datasets used by data scientists in the design and development of computer aided diagnosis (CAD) tools. This paper presents a deep learning (DL) approach for brain MRI sequence and view plane identification using scans of different data types as input. A 12-class classification system is presented for commonly used MRI scans, including T1, T2-weighted, proton density (PD), fluid attenuated inversion recovery (FLAIR) sequences in axial, coronal and sagittal view planes. Multiple online publicly available datasets have been used to train the system, with multiple infrastructures. MobileNet-v2 offers an adequate performance accuracy of 99.76% with unprocessed MRI scans and a comparable accuracy with skull-stripped scans and has been deployed in a tool for public use. The tool has been tested on unseen data from online and hospital sources with a satisfactory performance accuracy of 99.84 and 86.49%, respectively.
Clinical efficacy of prophylactic intravenous immunoglobulin for elderly DLBCL patients with hypogammaglobulinemia in the COVID-19 pandemic era
Authors: Baek Dong Won , Song Ga-Young , Lee Ho Sup , Do Young Rok , Lee Ji Hyun , Yhim Ho-Young , Moon Joon Ho , Yang Deok-Hwan
Published: April 2024

Background

Elderly patients diagnosed with diffuse large B-cell lymphoma (DLBCL) undergoing reduced intensity R-CHOP therapy are at a heightened risk of acquiring infections, notably coronavirus disease 2019 (COVID-19) infection. This study aimed to evaluate the efficacy of intravenous immunoglobulin (IVIG) as prophylaxis against COVID-19 in this vulnerable population.

Methods

A total of 125 elderly patients with DLBCL undergoing reduced intensity R-CHOP therapy were analyzed in this prospective, multicenter study. Patients with hypogammaglobulinemia were categorized into IVIG and non-IVIG groups, while those with normal immunoglobulin levels constituted the observation group. The study evaluated COVID-19 infection rates, therapy response, and safety outcomes.

Results

Among the enrolled patients (median age: 77 years), 89 patients (71.2%) presented with hypogammaglobulinemia at diagnosis, and 56 patients enrolled in the IVIG administration group. IVIG administration remarkably reduced COVID-19 infection rates compared to non-IVIG recipients (8.9% vs. 24.6%; p =0.040). Notably, patients over 80 years old were more susceptible to COVID-19. Patients on IVIG exhibited good tolerance with manageable adverse events. Among patients with hypogammaglobulinemia who received IVIG, 40.5% of patients developed additional immunoglobulin deficiencies during chemotherapy. One or more new hypogammaglobulinemia occurred during chemotherapy in 72% of patients with hypogammaglobulinemia who did not receive IVIG, and in 61.3% of patients who did not have hypogammaglobulinemia at diagnosis.

Conclusion

IVIG showed promise in reducing COVID-19 infections among elderly patients with DLBCL receiving reduced intensity R-CHOP therapy. This highlights IVIG’s potential as a prophylactic measure, necessitating further investigation to optimize dosing, administration schedules, and potential interactions with vaccination strategies.
Tumor burden affects the progression pattern on the prognosis in patients treated with sorafenib
Authors: Sun Jun , Xia Dongdong , Bai Wei , Li Xiaomei , Wang Enxing , Yin ZhanXin , Han Guohong
Published: April 2024

The progression pattern of tumors has an impact on the survival of patients with advanced hepatocellular carcinoma (HCC) and has been applied in the design of clinical trials for multiple second-line drugs. Previous research results have been contradictory, and the clinical impact of different progression patterns and their role in survival are still in question.

Purpose

The study aims to analyze the impact of different progression patterns and tumor burden size on survival of HCC patients, as well as their interactions, through a retrospective cohort study.

Patients and methods

The study involved 538 patients who had undergone treatment with sorafenib and had shown radiographic progression. The progression pattern was analyzed using Cox regression by including an interaction term between progression pattern and tumor burden, which was then visualized through a graphical analysis. Tumor burden was categorized into low, medium, and high subgroups based on the six-and-twelve criteria, allowing for an exploration of the effect of progression pattern on survival in different tumor burden situations.

Results

Compared to patients with only intrahepatic progression (NIH/IHG) with an overall survival (OS) of 14.1/19.9 months and post-progression survival (PPS) of 8.1/13.1 months respectively, patients with extrahepatic lesions (NEH/EHG) had worse overall and postprogressive survival (OS: 9.3/9.2 months, PPS: 4.9/5.1 months). The hazard ratio for extrahepatic progression (NEH/EHG) compared to intrahepatic progression (NIH/IHG) at low, medium, and high tumor burden were [HR 2.729, 95%CI 1.189-6.263], [HR 1.755, 95%CI 1.269-2.427], and [HR 1.117, 95%CI 0.832-1.499], respectively.

Conclusion

The study concluded that the interaction between the tumor progression patterns and tumor burden significantly affects the prognosis of HCC patients. As the tumor burden increases, the sensitivity of the patient’s risk of death to the progression pattern decreases. These findings are valuable in personalized treatment and trial design.
Sex-specific cardiovascular risk factors in the UK Biobank
Authors: St. Pierre Skyler R. , Kaczmarski Bartosz , Peirlinck Mathias , Kuhl Ellen
Published: April 2024

The lack of sex-specific cardiovascular disease criteria contributes to the underdiagnosis of women compared to that of men. For more than half a century, the Framingham Risk Score has been the gold standard to estimate an individual’s risk of developing cardiovascular disease based on the age, sex, cholesterol levels, blood pressure, diabetes status, and the smoking status. Now, machine learning can offer a much more nuanced insight into predicting the risk of cardiovascular diseases. The UK Biobank is a large database that includes traditional risk factors and tests related to the cardiovascular system: magnetic resonance imaging, pulse wave analysis, electrocardiograms, and carotid ultrasounds. Here, we leverage 20,542 datasets from the UK Biobank to build more accurate cardiovascular risk models than the Framingham Risk Score and quantify the underdiagnosis of women compared to that of men. Strikingly, for a first-degree atrioventricular block and dilated cardiomyopathy, two conditions with non-sex-specific diagnostic criteria, our study shows that women are under-diagnosed 2× and 1.4× more than men. Similarly, our results demonstrate the need for sex-specific criteria in essential primary hypertension and hypertrophic cardiomyopathy. Our feature importance analysis reveals that out of the top 10 features across three sexes and four disease categories, traditional Framingham factors made up between 40% and 50%; electrocardiogram, 30%–33%; pulse wave analysis, 13%–23%; and magnetic resonance imaging and carotid ultrasound, 0%–10%. Improving the Framingham Risk Score by leveraging big data and machine learning allows us to incorporate a wider range of biomedical data and prediction features, enhance personalization and accuracy, and continuously integrate new data and knowledge, with the ultimate goal to improve accurate prediction, early detection, and early intervention in cardiovascular disease management. Our analysis pipeline and trained classifiers are freely available at https://github.com/LivingMatterLab/CardiovascularDiseaseClassification.
“When I need help, I ask my friends”: experiences of Spanish autistic women when disclosing their late diagnosis to family and friends
Authors: Garcia-Molina Irene
Published: April 2024

Family and friends may play an important role both in the identification and diagnosis of any condition, as well as in the provision of support afterwards. However, when the diagnosis is autism and it arrives late, as is often the case with autistic women, we find the double stigma of experiencing the repercussions of a late diagnosis, along with the disbelief of those closest to them. This study aims to analyse and understand the experiences of autistic women with their family and friends throughout the diagnostic process and subsequent help-seeking endeavors. A total of 21 Spanish autistic women aged between 20 and 58 years answered a series of open-ended questions—respecting the participants' preferred modality. From the thematic analysis, two main themes emerged regarding the reactions of family and friends, dividing the experiences into two temporal phases: when disclosing the diagnosis and sometime later. Most participants noted that their relatives did not believe them, reacted in a hostile way, or did not give it any importance at the time of disclosure. As a result, their relationship deteriorated even further over time. In contrast, their friends served as pillars of support from the beginning, along with their partners and the associations they attended, because of which they met more autistic women who became their “family”. Thus, another consequence of late diagnosis in autistic women is highlighted, the incomprehension or disbelief from their relatives, and the important role of friendships among women and among autistic women.