bluuebunny/crossref_metadata_2025 huggingface dataset:
Tibial nerve decompression for the prevention of the diabetic foot: a cost–utility analysis using Markov model simulations
Authors: Sarmiento Samuel , Pierre Jr James A , Dellon A Lee , Frick Kevin D
Published: March 2019

Objective

To determine whether tibial neurolysis performed as a surgical intervention for patients with diabetic neuropathy and superimposed tibial nerve compression in the prevention of the diabetic foot is cost-effective when compared with the current prevention programme.

Design

A baseline analysis was built on a 5-year model to determine the cumulative incidence of foot ulcers and amputations with each strategy. Subsequently, a cost-effectiveness analysis and cohort-level Markov simulations were conducted with a model composed of 20 6-month cycles. A sensitivity analysis was also performed.

Setting

A Markov model was used to simulate the effects of standard prevention compared with tibial neurolysis on the long-term costs associated with foot ulcers and amputations. This model included eight health states.

Participants

Each cohort includes simulated patients with diabetic neuropathy at different levels of risk of developing foot ulcers and amputations.

Primary and secondary outcome measures

The primary outcome was the long-term trends concerning the development of ulcers and amputations with each strategy. The secondary outcome measures were quality adjusted life years (QALYs), incremental cost-effectiveness and net monetary benefits of the optimal strategy.

Results

When compared with standard prevention, for a patient population of 10 000, surgery prevented a simulated total of 1447 ulcers and 409 amputations over a period of 5 years. In a subsequent analysis that consisted of 20 6-month cycles (10 years), the incremental cost of tibial neurolysis compared with current prevention was $12 772.28; the incremental effectiveness was 0.41 QALYs and the incremental cost-effectiveness ratio was $31 330.78. Survival was 73% for those receiving medical prevention compared with 95% for those undergoing surgery.

Conclusion

These results suggest that among patients with diabetic neuropathy and superimposed nerve compression, surgery is more effective at preventing serious comorbidities and is associated with a higher survival over time. It also generated greater long-term economic benefits.
The effect of intranasal oxytocin on the perception of affective touch and multisensory integration in anorexia nervosa: protocol for a double-blind placebo-controlled crossover study
Authors: Crucianelli Laura , Serpell Lucy , Paloyelis Yannis , Ricciardi Lucia , Robinson Paul , Jenkinson Paul , Fotopoulou Aikaterini
Published: March 2019

Introduction

Anorexia nervosa (AN) is an eating disorder characterised by restriction of energy intake, fears of gaining weight and related body image disturbances. The oxytocinergic system has been proposed as a pathophysiological candidate for AN. Oxytocin is a neuropeptide involved in bodily processes (eg, breast feeding) and in the onset of social behaviours (eg, bonding). Studies investigating the effect of intranasal oxytocin (IN-OT) in AN showed that it can improve attentional bias for high-calorie food and fat bodies stimuli, and related stress. However, less is known about the effect of IN-OT on bodily awareness and body image distortions, key features of the disorder linked to its development, prognosis and maintenance. Here, we aim to investigate the effect of IN-OT on the perception of affective, C-tactile-optimal touch, known to be impaired in AN and on multisensory integration processes underlying a body ownership illusion (ie, rubber hand illusion). For exploratory purposes, we will also investigate the effect of IN-OT on another interoceptive modality, namely cardiac awareness and its relationship with affective touch.

Design, methods and analysis

Forty women with AN and forty matched healthy controls will be recruited and tested in two separate sessions; self-administering IN-OT (40 IU) or placebo, intranasally, in a pseudo-randomised manner. The data from this double-blind, placebo-controlled, cross-over study will be analysed using linear mixed models that allow the use of both fixed (treatment levels) and random (subjects) effects in the same analysis. To address our main hypotheses, separate analyses will be run for the affective touch task, where the primary outcome dependent variable will be the pleasantness of the touch, and for the rubber hand illusion, where we will investigate multisensory integration quantified as subjective embodiment towards the rubber hand. In the latter, we will manipulate the synchronicity of touch and the size of the hand.

Ethics and dissemination

Ethics approval has been obtained by National Research Ethics Service NRES Committee London (Queen’s Square Committee, ref number 14/LO/1593). The results will be disseminated through conference presentations and publication in peer-reviewed journals.
Association between caesarean section delivery and obesity in childhood: a longitudinal cohort study in Ireland
Authors: Masukume Gwinyai , McCarthy Fergus P , Baker Philip N , Kenny Louise C , Morton Susan MB , Murray Deirdre M , Hourihane Jonathan O’B , Khashan Ali S
Published: March 2019

Objectives

To investigate the association between caesarean section (CS) birth and body fat percentage (BF%), body mass index (BMI) and being overweight or obese in early childhood.

Design

Prospective longitudinal cohort study.

Setting

Babies After Screening for Pregnancy Endpoints: Evaluating the Longitudinal Impact on Neurological and Nutritional Endpoints cohort.

Participants

Infants born to mothers recruited from the Screening for Pregnancy Endpoints study, Cork University Maternity Hospital between November 2007 and February 2011.

Outcome measure

Overweight or obese defined according to the International Obesity Task Force criteria.

Results

Of the 1305 infants, 362 (27.8%) were delivered by CS. On regression analysis, BF% at 2 months did not differ significantly by delivery mode. Infants born by CS had a higher mean BMI at 6 months compared with those born vaginally (adjusted mean difference=0.24; 95% CI 0.06 to 0.41, p value=0.009). At 2 years, no difference was seen across the exposure groups in the risk of being overweight or obese. At 5 years, the association between prelabour CS and the risk of overweight or obesity was not statistically significant (adjusted relative risk ratio, aRRR=1.37; 95% CI 0.69 to 2.69) and the association remained statistically nonsignificant when children who were macrosomic at birth were excluded from the model (aRRR=0.86; 95% CI 0.36 to 2.08).

Conclusion

At 6 months of age, children born by CS had a significantly higher BMI but this did not persist into future childhood. There was no evidence to support an association between mode of delivery and long-term risk of obesity in the child.
Observational study protocol for evaluating control of hypertension and the effects of social determinants
Authors: Angier Heather , Huguet Nathalie , Marino Miguel , Green Beverly , Holderness Heather , Gold Rachel , Hoopes Megan , DeVoe Jennifer
Published: March 2019

Introduction

Hypertension is a common chronic health condition. Having health insurance reduces hypertension risk; health insurance coverage could improve hypertension screening, treatment and management. The Medicaid eligibility expansion of the Affordable Care Act was ruled not to be required by the US Supreme Court. Subsequently, a ‘natural experiment’ was produced with some states expanding Medicaid eligibility while others did not. This presents a unique opportunity to learn whether and to what extent Medicaid expansion can affect healthcare access and services for patients at risk for and diagnosed with hypertension, and patients with undiagnosed hypertension. Additionally, social determinants of health (SDH), at both the individual- and community-level, influence diagnosis and care for hypertension and it is important to understand how they interact with health insurance coverage changes.

Methods/design

We will use electronic health record (EHR) data fromtheAccelerating Data Value Across a National Community Health Center Network clinical data research network, which has data from community health centres in 22 states, some that did and some that did not expand Medicaid. Data include information on changes in health insurance, service receipt and health outcomes from 2012 through the most recent data available. We will include patients between the ages of 19 and 64 years (n=1 524 241) with ≥1 ambulatory visit to a community health centre. We will estimate differences in outcomes using difference-in-difference and difference-in-difference-in-difference approaches. We will test three-way interactions with insurance group, time and social determinants of health factors to compare the potential effect of gaining insurance on our proposed outcomes.

Ethics and dissemination

This study uses secondary data analysis and therefore approval for consent to participate was waived. The Institutional Review Board for OHSU approved this study. Approval reference number is: IRB00011858. We plan to disseminate our findings at relevant conferences, meetings and through peer-reviewed journals.

Trial registration number

NCT03545763.
Critical appraisal of adverse effects reporting in the ‘Treatment for Adolescents With Depression Study (TADS)’
Authors: Westergren Tone , Narum Sigrid , Klemp Marianne
Published: March 2019

Objective

To identify all publications from the ‘Treatment for Adolescents With Depression Study (TADS)’ and assess the findings regarding occurrence of any adverse effects in the treatment groups both for the short-term and long-term study stages.

Design

Descriptive analysis of TADS publications with any information on adverse effects.

Results

We identified 48 publications describing various aspects of the TADS, in which 439 adolescent patients received treatment with fluoxetine, cognitive–behavioural therapy, cognitive–behavioural therapy plus fluoxetine or placebo. Eight publications were assessed as providing some data on adverse effects. Risk of suicidal behaviour was the only adverse effect that was addressed in all publications. Several psychiatric and physical adverse effects were reported during the first 12 weeks, but not mentioned in reports from later study stages. Common adverse effects of fluoxetine, such as weight changes or sexual problems, were not identified or mentioned in the publications.

Conclusions

The TADS publications do not present a comprehensive assessment of treatment risk with fluoxetine in adolescents, especially for more than 12 weeks of treatment. Risk of suicidality was the only adverse effect that was reported over time. Reporting of adverse effects was incomplete with regard to the long-term safety profile of fluoxetine.
Dislocated distal radial fractures in adult patients: 4 weeks versus 6 weeks of cast immobilisation following reduction, a multicentre randomised controlled trial, study protocol
Authors: van Delft Eva A K , Bloemers Frank W , Sosef Nico L , Bonjer H J , Schep Niels W L , Vermeulen Jefrey
Published: March 2019

Introduction

Up to 30% of patients with a dislocated distal radial fracture (DRF) treated with closed reduction and cast immobilisation suffer from long-term functional restrictions. It remains unclear, whether duration of cast immobilisation influences functional outcome. The aim of this study is to evaluate whether the functional outcome of dislocated DRFs could be improved by shortening the period of immobilisation.

Methods and analysis

A single blinded multicentre randomised controlled trial is initiated. Four weeks of plaster cast immobilisation is compared with six week plaster cast immobilisation in adult patients with adequate reduced DRFs. Primary outcome parameters are functional outcome measured with the Patient Rated Wrist Evaluation after 1 year of follow-up (FU). Secondary outcomes are: Disability of Arm, Shoulder and Hand Score after 1 year, 36-Item Short Form Health Survey after 1 year, functional outcome earlier in FU (6 weeks, 12 weeks and 6 months), range of motion, pain level and complications: number of re-interventions, secondary dislocation, delayed and non-union.

Ethics and dissemination

The medical ethical committee VUmc approved the study protocol (2018.004, NL62861.029.17). The expectation of this study is that a shorter duration of plaster cast immobilisation is beneficial. This risk of specific complications is low and generally similar in both treatment options. FU is standardised according to current trauma guidelines. Present literature indicates that both treatment options that are used within this study are accepted protocols for treatment of dislocated DRFs. This trial will provide Level-I evidence for the comparison of functional outcome between the two treatment options for dislocated DRFs. Results of this study are expected to be published as a prospective, multicentre, randomised controlled trial article in 2021.

Trial registration

The Netherlands National Trial Register: NTR 6600, ABR: NL62861.029.17. Medical Ethical Committee VUmc registration number: 2018.004.
What are the research priorities for idiopathic intracranial hypertension? A priority setting partnership between patients and healthcare professionals
Authors: Mollan Susan , Hemmings Krystal , Herd Clare P , Denton Amanda , Williamson Shelley , Sinclair Alexandra J
Published: March 2019

Objective

Idiopathic intracranial hypertension (IIH) is under-researched and the aim was to determine the top 10 research priorities for this disease.

Design

A modified nominal group technique was used to engage participants who had experience of IIH.

Setting

This James Lind Alliance Priority Setting Partnership was commissioned by IIH UK, a charity.

Participants

People with IIH, carers, family and friends, and healthcare professionals participated in two rounds of surveys to identify unique research questions unanswered by current evidence. The most popular 26 uncertainties were presented to stakeholders who then agreed the top 10 topics.

Results

The top 10 research priorities for IIH included aetiology of IIH, the pathological mechanisms of headache in IIH, new treatments in IIH, the difference between acute and gradual visual loss, the best ways to monitor visual function, biomarkers of the disease, hormonal causes of IIH, drug therapies for the treatment of headache, weight loss and its role in IIH and finally, the best intervention to treat IIH and when should surgery be performed.

Conclusions

This priority setting encouraged people with direct experience of IIH to collectively identify critical gaps in the existing evidence. The overarching research aspiration was to understand the aetiology and management of IIH.
Effectiveness of complex multiple-risk lifestyle interventions in reducing symptoms of depression: a study protocol for a systematic review and meta-analysis of randomised controlled trials
Authors: Gómez-Gómez Irene , Motrico Emma , Moreno-Peral Patricia , Rigabert Alina , Conejo-Cerón Sonia , Ortega-Calvo Manuel , Recio José-Ignacio , Bellón Juan A
Published: March 2019

Introduction

Many studies have explored the impact of lifestyle interventions on depression. However, little is known about the effectiveness of complex multiple-risk lifestyle interventions in reducing symptoms of depression. Our objective is to assess the effectiveness of complex multiple-risk lifestyle interventions in reducing depressive symptoms in the adult population by the acquisition of at least two healthy habits—healthy diet, physical activity and/or smoking cessation. For such purpose, a systematic review and meta-analysis of randomised controlled trials will be conducted.

Method and analysis

MEDLINE (through Ovid and PubMed), Scopus, Cochrane Central Register of Controlled Trials, Web of Science, PsycINFO, OpenGrey Register (System for Information on Grey Literature in Europe) and the International Clinical Trials Registry Platform will be searched for relevant articles. Additionally, a supplementary manual search will be performed using lists of references, references to expert authors and other systematic reviews and/or meta-analyses. Study selection, data extraction (target habits, country, target populations, conditions and statistical data to name a few) and assessment of the risk of bias will be performed separately by two independent researchers. The primary outcome measure will be the reduction of depression symptoms, as measured by validated instruments. We will calculate pooled standardised mean differences and 95% CIs using random-effect models. Heterogeneity, sensitivity and publication bias will be assessed, and sub-group analysis will be performed. Heterogeneity will be explored by random-effects meta-regression analysis.

Ethics and dissemination

Ethical approval is not required for this study. The results of this systematic review and meta-analysis will be presented in relevant conferences and published in a peer-review journal. The findings of this study could have important clinical and scientific implications for the improvement of symptoms of depression.

PROSPERO registration number

CRD42018100253; Pre-results.
Ultrasound imaging versus palpation method for diagnostic lumbar puncture in neonates and infants: a systematic review and meta-analysis
Authors: Olowoyeye Abiola , Fadahunsi Opeyemi , Okudo Jerome , Opaneye Oluwakare , Okwundu Charles
Published: March 2019

Importance

Lumbar puncture (LP) failure rates vary and can be as high as 65%. Ultrasound guidance could increase the success of performing LP.

Objective

To summarise the evidence on the use of ultrasound guidance versus palpation method for LP.

Data sources

We searched computerised databases and published indexes, registries and references identified from bibliographies of pertinent articles without any language restrictions to find studies that compared ultrasound guidance to palpation method for performing an LP.

Study selection

Studies were included if they were randomised or quasirandomised trials in neonates and infants that compared ultrasound guidance with palpation method for performing an LP.

Data extraction and synthesis

Standardised data collection tool was used for data extraction, and two reviewers independently assessed the quality of the studies

Main outcome(s) and measure(s)

The primary outcome was the risk of LP failure, while the risk of traumatic tap, needle redirections/reinsertions and procedure durations were secondary outcomes

Results

Data from four studies and 308 participants is included in the analysis. Ultrasound imaging reduced the risk of LP failure, risk ratio of 0.58 (95% CI 0.15 to 2.28), but it was not statistically significant (p=0.44). Ultrasound imaging significantly reduced the risk of a traumatic tap risk ratio of 0.33 (95% CI 0.13 to 0.82) and p=0.02. The included studies had low to moderate quality; the studies differed based on mean age and with variability on outcome definition.

Conclusions and relevance

This meta-analysis suggests that ultrasound imaging has no effect in increasing lumbar success but is beneficial in reducing the risk of traumatic taps in neonates and infants.

Trial registration number

CRD42017055800.
Age independent survival benefit for patients with hepatocellular carcinoma (HCC) without metastases at diagnosis: a population-based study
Authors: De Toni Enrico N , Schlesinger-Raab Anne , Fuchs Martin , Schepp Wolfgang , Ehmer Ursula , Geisler Fabian , Ricke Jens , Paprottka Philipp , Friess Helmut , Werner Jens , Gerbes Alexander L , Mayerle Julia , Engel Jutta
Published: March 2019

Objective

Hepatocellular carcinoma (HCC) is a major cause of death worldwide and its incidence is expected to increase globally. Aim of this study was to assess whether the implementation of screening policies and the improvement of treatment options translated into a real-world survival benefit in HCC patients.

Design

4078 patients diagnosed with HCC between 1998 and 2016 from the Munich Cancer Registry were analysed. Tumour characteristics and outcome were analysed by time period and according to age and presence of metastases at diagnosis. Overall survival (OS) was analysed using Kaplan-Meier method and relative survival (RS) was computed for cancer-specific survival. Cox proportional hazard models were conducted to control for prognostic variables.

Results

While incidence of HCC remained substantially stable, tumours were diagnosed at increasingly earlier stages, although the median age at diagnosis increased. The 3 years RS in HCC improved from 19.8% in 1998–2002, 22.4% in 2003–2007, 30.6% in 2008–2012 up to 31.0% in 2013–2016. Median OS increased from 6 months in 1998–2002 to 12 months in 2008–2016. However, analysis according to the metastatic status showed that survival improved only in patients without metastases at diagnosis whereas the prognosis of patients with metastatic disease remained unchanged.

Conclusion

These real-world data show that, in contrast to the current assumptions, the incidence of HCC did not increase in a representative German region. Earlier diagnosis, likely related to the implementation of screening programmes, translated into an increasing employment of effective therapeutic options and a clear survival benefit in patients without metastases at diagnosis, irrespective of age.
Orchiectomy in Testudo species: technical aspects and effect on courtship behaviour
Authors: Hatt Jean‐Michel , Kummrow Maya , Wenger Sandra , Clauss Marcus
Published: March 2019

Courtship behaviour of tortoises includes biting, ramming, chasing, same‐sex sexual behaviour, and it commonly is excessive in European tortoise species kept as pets. As a result, males are kept individually. To assess the effect of orchiectomy on excessive courtship behaviour in European tortoises, 50 tortoises (Testudo graeca, T hermanni and T marginata) underwent endoscopically assisted orchiectomy from April through September 2013 to 2017. Statistical analyses were performed in relation to species, body mass, testicular size and season and owners were invited to fill out a follow‐up questionnaire. Body mass of the tortoises ranged from 334 to 2645 g (mean 1056 g) and the age from 5 to estimated 60 years. Testicular length ranged from 1.4 to 7.0 cm (mean 2.7 cm) and testicular mass from 0.6 to 12.6 g (mean 3.9 g). A complete or partial reduction (allowing group‐housing) of the excessive courtship behaviour was noted by 95 per cent of owners and 59 per cent of the owners reported a noticeable change of behaviour within a month of surgery. Given the seasonal variation in testicular size, the best period for castrations in male European tortoises is shortly after brumation (April, May), when testes are proportionally smaller.
O JOGO POÉTICO DE ADÍLIA LOPES: O PASTICHE NA CRIAÇÃO DO SENTIR LÍRICO
Authors: Sales Paulo Alberto da Silva
Published: March 2019

Partindo dos estudos sobre o pastiche, diferenciando-o da paródia, além das relações tensas entre vida e obra, entre poesia e prosa, entre ficção e realidade, este artigo analisa alguns poemas da poetiza portuguesa contemporânea Adília Lopes presentes nos livros Antologia, publicado em 2002 e em Dobra, publicado em 2009.
FIGURAÇÕES DO FEMININO NA POESIA ERÓTICA DE ALBERTO PIMENTA
Authors: Cardoso Inês
Published: March 2019

Resumo: Pensar a erotização do corpo feminino na poesia portuguesa da segunda metade do século XX exige a revisitação de uma nova imagem da mulher, que à altura se apresentou espelhada numa visão libertária da sexualidade feminina e na ação reivindicativa da luta feminista. Partindo das três primeiras obras de Alberto Pimenta, cuja publicação coincidiu, em território nacional, com o período de vigência do Estado Novo, este artigo procura compreender o modo como as figuras femininas emergem num fazer poético onde o erotismo sempre caminhou a par de uma denúncia profundamente cáustica e irreverente.Palavras-chave: Alberto Pimenta, poesia portuguesa, poesia erótica, figurações do feminino, erotismo. Abstract: In order to contemplate the eroticisation of the female body in Portuguese poetry from the second half of the twentieth century, it is necessary to re-visit the new image of woman, which at that time was reflected in a libertarian vision of female sexuality and in the increasing activism of the feminist struggle. Focusing on the first three works of Alberto Pimenta, whose publication coincided, in the Portuguese context, with the “Estado Novo” dictatorship, this article seeks to understand the way in which female figures emerge from a poetic practice where eroticism always appeared in tandem with a deeply caustic and irreverent social criticism.Keywords: Alberto Pimenta, Portuguese poetry, erotic poetry, representations of the feminine, eroticism.
PASSAGENS: UMA MEDITAÇÃO
Authors: Barros Bruno Mazolini de
Published: March 2019

Resenha do romance Passagens, de Teolinda Gersão.
A PROSA TRANSGRESSORA DE THERESA MARGARIDA DA SILVA E ORTA
Authors: Cardoso Beatriz Amazonas
Published: March 2019

O fato de Theresa Margarida da Silva e Orta, autora de As Aventuras de Diófanes, não pertencer aos cânones da literatura portuguesa nem da feminina constitui uma problemática que instigou nossa leitura. Criadora de um protorromance inspirado em obras clássicas como Odisséia (de Homero) e Télémaque (de Fénelon), Theresa Margarida é vista aqui como um retratista feminino dos cenários políticos, religiosos, sociais e culturais da época, em um ambiente dominantemente masculino. Como das mulheres letradas só era esperada e permitida a produção poética, a postura da autora portuguesa tem a conotação de transgressora, à luz dos conceitos de Foucault.The fact that Theresa Margarida was not part of the canons of neither Portuguese nor feminine literature is the main point of our text. Inspired by Homer’s Odyssey and Fénelon’s Télémaque, Theresa Margarida, who created the “protorromance” As Aventuras de Diófanes, is faced by this work as a female portraitist of the political, religious, social, and cultural scenarios of her time, within a dominantly male environment. The Portuguese writer can be considered a transgressor of that time, through the thoughts of Foucault.
HUMANIDADE E ANIMALIDADE NO CONTEXTO PORTUGUÊS
Authors: Matangrano Bruno Anselmi , Sasaki Leonardo de Barros
Published: March 2019

Editorial do n. 19 - O Imaginário Animal na Literatura Portuguesa
A "MÍMESIS" FANTÁSTICA NA OBRA SATÍRICA DE NICOLAU TOLENTINO E O "VT PHOTOGRAPHIA POESIS"
Authors: Pinto Rodrigo Gomes de Oliveira
Published: March 2019

Na obra satírica do poeta lusitano Nicolau Tolentino de Almeida (1740-1811), os sonetos “Aos toucados altos” e “O colchão dentro do toucado” podem ser lidos como exemplares de poesia cômico-fantástica composta no domínio da prescrição da arte mimética. Assim, feitos da nitidez, da clareza e da vivacidade efetuadas pela figura retórica da hipotipose, os versos desses sonetos fazem parecer empírico o fingido, a fim de escarnecer costumes vistos como desmedidos e fazer iteração moralizante do comedimento. Manuel Pinheiro  Chagas (1842-1895), leitor oitocentista de Nicolau Tolentino, afirma que o uso do verbo “photographar” não é capaz de dizer a vividez descritiva dos versos desses sonetos, de modo que não pareça conveniente ler a obra poética do satirista de acordo com parâmetros que postulem uma espécie de ut photographia poesis.
PEIXES E HOMENS: O PESCAR ALEGÓRICO DE ANTÓNIO VIEIRA
Authors: Thimóteo Saulo Gomes
Published: March 2019

Há, na obra de António Vieira, um movimento contínuo entre figuras, vindas não somente da Bíblia ou da vida dos santos, mas também de elementos da natureza e da sociedade. Isso se torna visível, por exemplo, no “Sermão de Santo António”, escrito em 1654, no qual a figura do santo se conecta a uma variedade de peixes. Cada um deles é evocado por Vieira como uma parte que forma uma rede de metáforas, construindo, por fim, uma pesca destinada aos homens.
MIURA, AQUELE QUE DÁ A VIDA, OU O DESVENDAR DA NOSSA ANIMALIDADE
Authors: Silva Marco
Published: March 2019

Unidas pela presença simbólica de um touro e pelas relações diretas e íntimas que esse animal desenvolve perante o ser humano, os contos «Miura», de Miguel Torga, e «Aquele que dá a vida», de Herberto Helder, instauram uma espécie de entrelaçamento que nos permite ter a percepção da animalidade que habita no ser humano, uma característica que foi sendo esquecida pelo sentimento de valorização do antropocentrismo e da racionalidade. Neste sentido, assiste-se, em ambas as narrativas, a um desvendar dessa animalidade que corresponde a um exercício de alteridade. O nosso objetivo aqui passa justamente por atestar esta realidade.
JOSÉ DE ALMADA NEGREIROS E O FIM DA ADIÇÃO
Authors: Barbosa Lopez Nicolas
Published: March 2019

Este artigo parte da quebra de códigos que simboliza da versão profana da álgebra que propõe José de Almada Negreiros. A análise concentra-se em um conjunto de aspectos centrais de A Cena do Ódio, poema que Almada Negreiros escreveu para publicar em Orpheu 3, em 1915, sob a luz da teoria que ele mesmo elucidou em um texto publicado dois anos depois, a 1ª Conferência Futurista. A análise, portanto, gira em torno das ideias da multiplicidade e da destruição, e sua manifestação ao longo de vários fios temáticos, como o ódio, o sexo e a própria linguagem.
A PARTITURA DO ORPHEU: O LUGAR DE "A CENA DO ÓDIO", DE ALMADA NEGREIROS
Authors: Amorim Orlando Nunes de
Published: March 2019

Variados trabalhos críticos têm acentuado o que se poderia chamar de "orquestração" dos textos da revista Orpheu (1915), ou seja, não só o estabelecimento dos lugares específicos e propositadamente escolhidos da colaboração de cada poeta na distribuição interna de cada número da revista, mas também certas relações paralelísticas entre os diferentes textos e autores de um número para outro. Para além de uma simples reunião de colaboração poética de certas afinidades eletivas, o Orpheu, no que respeitava à sua organização interna, parece mesmo ter sido cuidadosamente elaborada pelos seus idealizadores. Considerando que o terceiro número da revista, mesmo que não tenha vindo a público, também foi organizado para publicação, este trabalho tem por objetivo analisar o lugar de "A cena do ódio", de Almada Negreiros, na referida orquestração da aventura órphica, sobretudo no que se refere à observação das relações que o poema estabelece com os outros grandes poemas ditos revolucionários que pontuaram a publicação (a "Ode triunfal" em Orpheu 1, o "Manicure" e a "Ode marítima" em Orpheu 2).
PRÁTICA POÉTICO-NARRATIVA EM TORNO DE ORPHEU
Authors: Martins Dias Maria Heloísa
Published: March 2019

O presente texto toma como material fragmentos, versos e passagens de obras de Fernando Pessoa, sobretudo o ortônimo, com o propósito de recriá-los ao inseri-los em novo contexto. O propósito é mostrar como as motivações líricas contidas na “modernidade” proposta pelo poeta português podem se abrir a revisitações criativas, desde que o olhar crítico com elas dialogue. Tal diálogo reforça a importância de uma obra que parece solicitar a intensa participação do leitor como sujeito ativo, participativo e, por que não, também criador. Nesse sentido, pode-se atingir um dos efeitos desejados por Pessoa no conjunto de sua obra: o caráter dramático ou performático de sua poética.
BREVE DEPOIMENTO SOBRE A REVISTA ORPHEU
Authors: Berardinelli Cleonice
Published: March 2019

Em razão do centenário da revista Orpheu, a Professora Doutora Gilda da Conceição Santos gravou um depoimento da Professora Doutora Cleonice da Motta Berardinelli, pioneira dos estudos pessoanos no Brasil e sem a qual nosso congresso comemorativo 100Orpheu não estaria completo. Agora trazemos uma versão transcrita e editada de sua fala para a seção de entrevistas da edição sobre “Modernismos” da Revista Desassossego.
A LENDA DE FERNANDO PESSOA
Authors: Silva Cassia Alves
Published: March 2019

O texto que segue apresenta uma resenha da obra A lenda de Fernando Pessoa, da escritora e professora da Universidade Federal de Pernambuco Lucila Nogueira. O livro resenhado se destaca por sua singularidade no que diz respeito aos estudos sobre Fernando Pessoa, apresentando um olhar atento e sensível à poesia dos três principais heterônimos e do ortônimo. Assim, destacaremos a análise proposta por Lucila Nogueira em quatro capítulos, dando ênfase ao seu olhar diferenciado.
APRESENTAÇÃO: DESASSOSSEGO E ORPHEU
Authors: Jacoto Lilian
Published: March 2019

Apresentação do dossiê “100 anos da Revista Orpheu”.
"I FUTURISTI" E OS FUTURISTAS DE "ORPHEU" (SANTA-RITA PINTOR E ALMADA NEGREIROS)
Authors: Pereiro Carlos Paulo Martínez
Published: March 2019

I futuristi e os futuristas de Orpheu(Santa-Rita Pintor e Almada Negreiros) RESUMO: Este artigo parte da (re)conhecida ideia almadiana de a revista Orpheu ter representado o “encontro português das letras e da pintura” – isto é, o entrecruzado affaire verbale et visuelle que a delimita de maneira basilar e a que a publicação obedece como princípio reitor. Trata-se, por um lado, de analisar criticamente o obstinado rigor interartístico derivado da dupla obediência criativa do (para)futurista e poliapto criador Almada Negreiros e, por outro lado, de dissertar, in absentia, dos quatro hors-texte duplos do (pro)futurista e mitificador Santa-Rita Pintor, reproduzidos no segundo número da efémera e marcante publicação literária portuguesa.Destarte, inter alia, além de dissertarmos sobre a questão dos futuristi primários no que diz respeito desses dois ‘futuristas derivados’, ponderando a pensée contraditória e o pensum amalgamático que alicerzam a sua elaboração, procuramos ler as transitivas e concretas criações em palavras e/ou imagens de Almada e Santa-Rita – isto é, distantes de qualquer ‘imaculada concepção’, pretendemos decifrá-las, decodificá-las e/ou interpretá-las dentro dos referentes programáticos e efetivos de um futurismo tou court.  I futuristi and the Futurists of Orpheu(Santa-Rita Pintor and Almada Negreiros)ABSTRACT: This article takes as its starting point the (well-) known Almadian idea that the magazine Orpheu represented the “Portuguese meeting point for literature and painting” – that is, the crossroads for affaire verbale et visuelle which defines it fundamentally and which the publication takes as its guiding principle. It is our intention, on the one hand, to review the obstinate inter-artistic rigor which is derived from the dual creative obedience to the (para) futuristic and multi-faceted creator Almada Negreiros and, on the other hand, to discuss, in absentia, of the four dual hors-texte by the (pro) futuristic myth-maker Santa-Rita Pintor, reproduced in the second number of this ephemeral and remarkable Portuguese literary publication.Thus, inter alia, in addition to discussing the question of the first futuristi with respect to these two 'derived futurists', considering the contradictory pensée and the amalgamated pensum that lay the foundation for their preparation, we endeavour to read the transitive and concrete creations in the words and / or pictures of Almada and Santa-Rita – that is, far from any 'immaculate conception', we aim to decipher them, decode them and / or interpret them within the programmatic and effective respect of a tou court futurism.
MEMÓRIAS DO FUTURO PASSADO: a história de um horizonte desejado
Authors: Ribeiro Leonardo Lima
Published: March 2019

O texto de ficção propõe descrever como narrativa modos de inconsciência humana, modos de inconsciência que estão a subsidiar, como passado histórico infinitamente repetível, a elaboração concreta de descaminhos vertiginosos os quais, espandindo-se, servem ao homem como horizonte ineludível.
SEGUINDO OS PASSOS DE PAULA E CLB: A TENTATIVA DE TRANSGRESSÃO EM PEDRO E PAULA, DE HELDER MACEDO E EM A CASA DOS BUDAS DITOSOS, DE JOÃO UBALDO RIBEIRO
Authors: Marinho Ingrid Da Silva
Published: March 2019

O desejo de transgressão sempre foi algo que impulsionou, de certa forma, a vida da mulher, mesmo que inconsciente. Paula e CLB são personagens que expressam esse desejo, mas que, por algum motivo ou em algum momento da narrativa, são impedidas de continuar no caminho da transgressão. Isso reforça a ideia de que a tradição patriarcal instaurada na sociedade ainda subjuga a mulher mesmo quando ela tenta seguir um caminho diferente, as raízes do machismo tornam-se mais fortes. Através da análise das narrativas e do suporte teórico de Simone de Beauvoir e Judith Butler, percebemos que, ainda assim, a tentativa de transgressão não é em vão, uma vez que ambas as personagens alcançam, até certo ponto, certas liberdades, entre elas a liberdade sexual.
CASIMIRO DE BRITO: O “RIGOR E A CLARIDADE ENIGMÁTICA DO PENSAMENTO”
Authors: Barros Teixeira Claudio Alexandre
Published: March 2019

RESUMO O artigo aborda o trabalho desenvolvido por Casimiro de Brito para a divulgação da poesia japonesa em Portugal por meio da tradução, da reflexão crítica e do próprio exercício poético na forma do haicai, adaptada às possibilidades da língua portuguesa. Entre as questões teóricas apresentadas no presente texto está a discussão sobre a atividade tradutória compreendida como recepção criativa, que estabelece uma tensão entre a língua de partida e a de chegada, entre diferentes repertórios culturais e tempos históricos, transformando o texto original em um novo artefato semântico.
NO ESPAÇO DO POEMA: A PRESENÇA DO REAL - UMA RELAÇÃO ENTRE O POEMA E A FOTOGRAFIA NA POESIA DE SOPHIA DE MELLO BREYNER ANDRESEN
Authors: Nahas Nathália Macri
Published: March 2019

A partir da análise de “No poema”, propomos uma leitura de analogia entre as percepções sobre poesia para a autora portuguesa Sophia de Mello Breyner Andresen e a noção de “fotografia”, ressaltando a visão dela sobre o fazer poético ser uma busca pelo real. Desse modo, o poema surge como um elemento presentificador do mundo, por meio dele, podemos ver, sentir, logo nos conectamos ao real. Esses aspectos são lidos em comparação com a fotografia e seu papel também de reprodução da realidade, de presentificador dos elementos do mundo.
QUANDO APARECE O LOBO, PORTANTO QUANDO APARECE O MAL, COMEÇA A LITERATURA. ENTREVISTA A GONÇALO M. TAVARES
Authors: Jacoto Lilian
Published: March 2019

A entrevista busca mapear as relações entre a ficção de Gonçalo M. Tavares e a Ética.
JUDITE: NOME DE UMA HISTÓRIA RESIDUAL
Authors: Martins Elizabeth Dias , Leitão Mary Nascimento da Silva
Published: March 2019

A personagem Judite em Nome de Guerra de Almada Negreiros é a representação de uma imagem feminina ainda atrelada a preceitos de tempos remotos, principalmente medievais. Esse olhar voltado para remanescências de outras épocas em vigor na modernidade é procedido à luz da teoria da residualidade (PONTES, 1999), que identifica traços de mentalidade do passado arraigados em obras literárias dos diversos períodos literários posteriores. Assim, a mulher vista da perspectiva do olhar masculino, bem como, as nuanças de um perfil feminino engendradas na mente do homem e a relação fraqueza versus fortaleza como concepção estereotipada do feminino/frágil/inferior versus masculino/forte/superior, são alguns dos aspectos a serem discutidos ao longo desse trabalho.
ERA UMA VEZ... ENTRE A TRADIÇÃO E A MODERNIDADE NAS VERSÕES DO CONTO “BRANCA DE NEVE”
Authors: Batista Adriane Figueira
Published: March 2019

A figura da mulher foi e ainda é motivo de grandes contrastes dentro do cenário social e político, e isso se reflete no discurso literário. É por essa razão que faço emergir um olhar estético sobre duas personagens distantes, e, ao mesmo tempo próximas: Brancas de Neve; a princesa que habita no imaginário dos contos de fadas e Maria da Graça, a gerente bancária e personagem central do conto de Lídia Jorge. A primeira do século XIX, menina perdida na floresta, após ser deixada lá pelo caçador a mando de sua “madrasta” invejosa e cercada por sete anões; e a segunda do século XXI, mulher perdida na “selva de pedras” de uma grande cidade que, após um longo e produtivo dia de trabalho, se vê cercada por sete crianças, que caminham na aba de seu casaco durante uma noite fria de véspera de natal.
Fraturas, carste e cavernas nos calcários Jandaíra em Felipe Guerra, Rio Grande do Norte
Authors: Gomes Iris Pereira , Veríssimo César Ulisses Vieira , Bezerra Francisco Hilário Rego , Santos Jefferson Lima dos , Câmara José Ronaldo De Freitas
Published: March 2019

Condicionantes estruturais e geológicos foram estudados no lajedo do Arapuá em Felipe Guerra, oeste da Bacia Potiguar, com objetivo de avaliar sua influência no controle e na evolução de feições cársticas em carbonatos cretáceos da Formação Jandaíra. O arranjo estrutural das descontinuidades mostra a existência de quatro famílias de fraturas com direções preferenciais: NW-SE, NE-SW, N-S e E-W, as quais coincidem tanto com os principais sistemas de falhas da Bacia Potiguar como com a direção de desenvolvimento de cavernas na área de estudo. A caverna de Arapuá, principal cavidade da área, foi mapeada em escala de detalhe e realizado o levantamento estrutural das descontinuidades presentes no seu interior. As galerias principais que delimitam o contorno da caverna, as fendas e os alinhamentos de estalactites no teto, obedecem ao controle estrutural similar observado na superfície do lajedo. A simulação estocástica booleana aplicada às descontinuidades da área estudada permitiu a geração de gráficos tridimensionais que forneceram uma visão tridimensional (3D) da intensidade e da orientação espacial das estruturas em três profundidades distintas, reforçando a tendência das direções de fraturamento reconhecidas em superfície, com grande redução da ocorrência e penetratividade das direções E-W e N-S com a profundidade. O arranjo estrutural local coincide com o regional observado na Bacia Potiguar, configurado por um sistema de falhas extensionais que limitam altos e baixos estruturais orientados segundo NE-SW e NW-SE, herdados da fragmentação do supercontinente Gondwana e da abertura do Atlântico Sul. Pequenas falhas NE-SW com movimentação direcional dextral sugerem associação com estruturas reativadas em regime transcorrente. Entre as diferentes fácies reconhecidas nas seções da caverna de Arapuá, os mudstones e os carbonatos cristalinos correspondem
Acute Effects of Heat‐Not‐Burn, Electronic Vaping, and Traditional Tobacco Combustion Cigarettes: The Sapienza University of Rome‐Vascular Assessment of Proatherosclerotic Effects of Smoking (SUR‐VAPES) 2 Randomized Trial
Authors: Biondi‐Zoccai Giuseppe , Sciarretta Sebastiano , Bullen Christopher , Nocella Cristina , Violi Francesco , Loffredo Lorenzo , Pignatelli Pasquale , Perri Ludovica , Peruzzi Mariangela , Marullo Antonino G.M. , De Falco Elena , Chimenti Isotta , Cammisotto Vittoria , Valenti Valentina , Coluzzi Flaminia , Cavarretta Elena , Carrizzo Albino , Prati Francesco , Carnevale Roberto , Frati Giacomo
Published: March 2019

Background

Little clinical research on new‐generation heat‐not‐burn cigarettes (
HNBC
) in comparison with electronic vaping cigarettes (
EVC
) and traditional tobacco combustion cigarettes (
TC
) has been reported. We aimed to appraise the acute effects of single use of
HNBC
,
EVC,
and
TC
in healthy smokers.

Methods and Results

This was an independent, cross‐over, randomized trial in 20
TC
smokers, with allocation to different cycles of
HNBC
,
EVC
, and
TC
. All participants used all types of products, with an intercycle washout of 1 week. End points were oxidative stress, antioxidant reserve, platelet activation, flow‐mediated dilation, blood pressure, and satisfaction scores. Single use of any product led to an adverse impact on oxidative stress, antioxidant reserve, platelet function, flow‐mediated dilation, and blood pressure.
HNBC
had less impact than
EVC
and
TC
on soluble Nox2‐derived peptide (respectively,
P
=0.004 and 0.001), 8‐iso‐prostaglandin F2α‐
III
(
P
=0.004 and <0.001), and vitamin E (
P
=0.018 and 0.044).
HNBC
and
EVC
were equally less impactful than
TCs
on flow‐mediated dilation (
P
=0.872 for
HNBC
versus
EVC
), H
2
O
2
(
P
=0.522), H
2
O
2
breakdown activity (
P
=0.091), soluble
CD
40 ligand (
P
=0.849), and soluble P‐selectin (
P
=0.821). The effect of
HNBC
and, to a lesser extent
EVC
, on blood pressure was less evident than that of
TC
, whereas
HNBC
appeared more satisfying than
EVC
(all
P
<0.05).

Conclusions

Acute effects of
HNBC
,
EVC,
and
TC
are different on several oxidative stress, antioxidant reserve, platelet function, cardiovascular, and satisfaction dimensions, with
TCs
showing the most detrimental changes in clinically relevant features.

Clinical Trial Registration

URL
:
http://www.clinicaltrials.gov
. Unique identifier:
NCT
03301129.
Contemporary Outcomes in Low‐Gradient Aortic Stenosis Patients Who Underwent Dobutamine Stress Echocardiography
Authors: Sato Kimi , Sankaramangalam Kesavan , Kandregula Krishna , Bullen Jennifer A. , Kapadia Samir R. , Krishnaswamy Amar , Mick Stephanie , Rodriguez L. Leonardo , Grimm Richard A. , Menon Venu , Desai Milind Y. , Svensson Lars G. , Griffin Brian P. , Popović Zoran B.
Published: March 2019

Background

Detection of flow reserve (
FR
) by dobutamine stress echocardiography is used for risk stratification in low‐gradient aortic stenosis (
AS
). Prognostic significance of dobutamine stress echocardiography in the transcatheter aortic valve replacement era is unclear. We aimed to assess the current relevance of
FR
.

Methods and Results

We studied 235 patients with low‐gradient severe
AS
(rest aortic valve area ≤1.0 cm
2
or indexed aortic valve area ≤0.60 cm
2
/m
2
; mean aortic valve gradient <40 mm Hg) and left ventricular ejection fraction <50%) with dobutamine stress echocardiography done September 2010 through July 2016.
FR
was defined by ≥20% stroke volume increase. We diagnosed “true‐severe
AS
” if peak aortic valve velocity ≥4 m/s occurred with aortic valve area ≤1.0 cm
2
(or indexed aortic valve area ≤0.6 cm
2
/m
2
). At a median time of 51 days, 128 patients underwent aortic valve replacement,either surgical aortic valve replacement (n=42) or transcatheter aortic valve replacement (n=86).
FR
was observed in 138 patients, while 86 patients had true‐severe
AS
. During median follow‐up of 2.3 years, 138 patients died. In a multivariable model, aortic valve replacement (hazard ratio 0.41, 95%
CI
: 0.29–0.58,
P
<0.001) and lower Society of Thoracic Surgeons score (hazard ratio 1.06, 95%
CI
: 1.04–1.09,
P
<0.001) were associated with better survival, while
FR
was not predictive. aortic valve replacement was associated with survival regardless of the presence or absence of
FR
or
AS
severity stratification.

Conclusions

In low‐gradient
AS
with reduced ejection fraction,
FR
or
AS
severity stratification by dobutamine stress echocardiography was not associated with survival. Aortic valve replacement was associated with better survival in low‐gradient
AS
independent of
FR
.