bluuebunny/crossref_metadata_2025 huggingface dataset:
Playing With Your Emotions
Authors: Veletsianos George , Houlden Shandell , Hodson Jaigris , Gosse Chandell , Thompson Christiani , O'Meara Victoria
Published: November 2023

As a result of the COVID-19 pandemic, online misinformation has proliferated, requiring innovative interventions to improve information literacy for the public. In this paper we report on an evaluation of an interactive narrative education intervention developed as part of a design-based research project into microlearning and COVID-19 misinformation. The intervention aimed to enable learners to (1) name the role that fear and anger play in the spread of misinformation, and (2) identify a strategy for interrupting the spread of misinformation driven by fear or anger. Using a pre- and post-test design, we surveyed 195 Canadian women to evaluate whether the intervention was effective at achieving its learning outcomes. Results indicate that the intervention was effective in improving understanding about emotionally-driven misinformation, the role of emotions in the circulation of misinformation, and self-efficacy with respect to this type of misinformation. Based on these results, we suggest that short interactive narratives may be useful in education efforts aimed to address online misinformation and that this technique may have wide appeal to educators seeking accessible web tools for teaching this type of content.
English Teaching Practice and Research Under the Joyful English Philosophy
Authors:   Yixin Publisher, Li Yanni
Published: November 2023

This paper examines English teaching practice and research under the Joyful English philosophy. It emphasizes the essence of the Joyful English philosophy, analyzes the characteristics of Joyful English teaching, and identifies the challenges faced in Joyful English education, and anticipates future trends, including the integration of education and technology, the fusion of interdisciplinary education and personalized learning, and the development of a multicultural education evaluation system. The paper underscores the value and impact of Joyful English teaching while also presenting methods to address challenges and seize future opportunities, aiming to continuously enhance the quality and effectiveness of English education.
IDENTIFIKASI MARKA MOLEKULER DAYA TAHAN INFEKSI Aeromonas hydrophila PADA LELE DUMBO Clarias gariepinus DENGAN METODE RAPD-PCR
Authors: Safitri Ika , Nasrullah Hasan
Published: November 2023

Pencegahan penyakit motile aeromonas septicemia (MAS) pada ikan lele dumbo (Clarias gariepinus)  dapat dilakukan melalui seleksi ikan berbasis marka molekuler menggunakan teknik random amplified polymorphic DNA PCR (RAPD-PCR) untuk mengidentifikasi keberadaan fragmen pita yang kemungkinan terkait dengan daya tahan terhadap penyakit MAS. Penelitian ini bertujuan untuk mengidentifikasi kandidat marka molekuler daya tahan penyakit pada ikan lele dumbo setelah diinfeksi bakteri Aeromonas hydrophila. Penelitian ini menggunakan 4 jenis primer RAPD dengan sekuen berbeda sebagai tahap optimasi kerja. Sampel DNA yang diamati berasal dari ikan yang tahan (resistant) dan rentan (susceptible) pascainfeksi masing-masing sebanyak 8 sampel. Hasil penelitian ini menunjukkan bahwa kandidat marka molekuler terkait daya tahan terhadap infeksi bakteri Aeromonas hydrophila pada lele dumbo bertahan hidup pasca penyuntikan bakteri A.hydrophila 107 CFU ml-1 memiliki pita DNA berukuran sekitar 1700 bp dengan peluang populasi resistan sebesar 87.5%.
INSIDENSI EKTOPARASIT PROTOZOA PADA IKAN AIR TAWAR DI KECAMATAN SERUYAN HILIR
Authors: Herlina Sri , Rozikin Ifisar , Purnamasari Tina , - Yudi
Published: November 2023

Tujuan penelitian ini adalah untuk mengetahui tingkat insidensi ektoprasit protozoa pada ikan air tawar dan jenis-jenis ektoparasit apa saja yang menginginfeksi ikan air tawar serta seberapa besar tingkat serangan ektoparasit terhadap ikan di Kecamatan seruyan Hilir. Penelitian dilaksanakan pada bulan Maret- April 2022. Metode pemeriksaan sampel adalah Metode Scraping yaitu melakukan pengerokan lendir dari kulit ikan dan Metode Biopsi yaitu mengambil sebagian dari jaringan insang. Analisa deskriptif digunakan untuk mengambarkan tingkat serangan ektoprasit protozoa pada air tawar. Ada 3 jenis ektoprasit protozoa yang ditemukan pada ikan sampel yang ada di Kecamatan Seruyan Hilir yaitu jenis parasit Oodinium sp., Tricodina sp. dan Chilodonella sp. Nilai Insidensi pada ikan Nila maupun Ikan Patin, yaitu sebesar (100%) masuk dalam kategori selalu (terinfeksi sangat Parah) dengan jenis parasit Oodinium sp. Nilai Intensitas tertinggi pada ikan Nila dan Patin jumlah tertinggi adalah jenis ektoparasit Oodinium sp. Nila (10,5 ind/ekor) dan ikan Patin (16,5 ind/ekor)
PENGARUH PEMBERIAN EKSTRAK DAUN RAMBUSA ( Passiflora foetida L) TERHADAP GAMBARAN DARAH IKAN PAPUYU (Anabas testudineus)
Authors: * Herliani , Herlina Sri
Published: November 2023

Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh ekstark daun rambusa terhadap gambaran darah ikan papuyu dan untuk mengetahui berapakah nilai hemoglobin, leukosit, ikan papuyu, eritrosit yang diberi pakan dengan tambahan ekstrak daun rambusa. Penelitian dilaksanakan selama 42 hari pada bulan April-Mei 2021. Penelitian mengunakan Rancangan Acak Lengkap (RAL) dengan 4 perlakuan dan 3 Ulang . Perlakuan A (EDR 50 ml), Perlakuan B (EDR 75 ml). Perakuan C (EDR 125 ml) dan Perlakuan D (Kontrol). Hasil penelitian menunjukan bahwa pemberian ekstrak daun rambusa memberikan pengaruh nyata terhadap gambaran darah ikan papuyu. Hemoglobin berkisar 5-8,9 gr %, eritrosit 87.657 - 154.467 sel/ mm3 , Leukosit 3.55 X106 – 4.35x106 dan Kelangsungan hidup sebesar 100%.
Hakikat Filsafat Hukum dalam Perspektif Filsafat Hukum Islam
Authors: Masruchi Zainal Aris
Published: November 2023

Philosophical discussion often makes it seem as though we are in an abstract setting, and legal philosophy is a subfield of philosophy. Legal philosophy has a crucial role in how Indonesian legislation is created. implying that in Islam, the rule of law applies to both this world and the afterlife since a just judgement or punishment not only affects people directly but also the Creator (Allah SWT). Therefore, humanity must always seek out the formula of truth that is spread throughout people's lives, namely a rule that will govern the path of society and the law that governs the heavenly (or, in Islam, direct) laws of God's revelation. It is essential to conduct a more thorough investigation of legal theory. This page seeks to explain what legal philosophy is, why it's beneficial to study it, and how Islamic legal philosophy differs from other legal systems.
Strategi Pengembangan Objek Wisata Teluk Biru (Selanggrong) di Kecamatan Muncar Kabupaten Banyuwangi
Authors: Yazid Azy Athoillah
Published: November 2023

Since tourism is growing more quickly and there is fierce rivalry, company owners in the industry work hard to provide every guest the greatest experience possible. Teluk Biru (Selanggrong) is one of the intriguing and well-known tourist sites in Banyuwangi nowadays. This tourism destination has undergone the most changes in managerial development in recent years. A strategy for creating tourist attractions that prioritizes the supply of facilities and infrastructure, expanding the involvement of the local community, quality of service, and promotion results in better tourism development. The purpose of this study is to outline the development plan for tourism attractions employed by Teluk Biru's (Selanggrong) management. In this study, descriptive methods are used with qualitative data. Interviews, observation, and documentation were the data gathering techniques employed. The findings of the study indicate that a well-executed development strategy may increase the number of tourists and the revenue from tourism attractions. Traveling to Teluk Biru (Selanggrong) may be made simpler for guests if adequate facilities and services are offered. One of the methods to draw guests is the Underwater Festival event. The administration runs effective marketing campaigns to promote Teluk Biru (Selanggarong) tourism.
DEVELOPING TOLERANCE IN PRESCHOOL CHILDREN: PROBLEMS AND APPROACHES
Authors: Chernova Anastasiya , Grigoryan Amalia
Published: November 2023

Tensions in interethnic relations complicate a person’s adaptation
to a multi-ethnic world. The high preschool age is a sensitive stage for
tolerance development. As a quality of personality, it determines value attitude
to the world, to others, and to oneself. The purpose of our research is
to examine the problems and approaches in the formation of tolerance in
preschool age. Methods. Theoretical analysis and synthesis of scientifi c literature
were used as methods of research. Main results. Theoretical analysis
demonstrated that there is no single view on the defi nition of tolerance. Foreign
and Russian scientists consider this concept as a quality of personality,
as an ability, as a position or attitude. It should also be noted that foreign
studies most often consider educational environment as a condition in the
formation of tolerance in older preschool children. In Russian studies the primary
role of the family in the formation of tolerance is considered. After analyzing
the psychological and pedagogical literature, it should be noted that
the methods of tolerance diagnostics are presented to a greater extent for
primary schoolchildren, adolescents, and adults. For the study of tolerance
at preschool age, most often methods that examine the emotional sphere of
the preschooler and the level of well-being in the children’s group are used.
Conclusion. Despite the actuality of this phenomenon and its wide dissemination,
there is no clear explanation of tolerance in psychological and pedagogical
science. Having analyzed the research on this topic, we came to the
conclusion that there are certain diffi culties with diagnostic tools, allowing
to study the formation of tolerance in the late preschool age. The infl uence
of the family on the formation of tolerance as a personality quality is insuffi -
ciently studied.
INTERPERSONAL RELATIONSHIPS OF ADOLESCENTS WITH COMPUTER ADDICTION
Authors: Zholudeva Svetlana
Published: November 2023

Online communication often attracts teenagers due to its anonymity
and the ability to openly express their points of view. A signifi cant
advantage is real-time communication. However, there is also a drawback of
developing teenagers’ addiction to computers. The dissatisfaction of teenagers
with business and personal relationships, the discrepancy between the
importance of communication spheres and the peculiarities of a teenager’s
age are among the most serious factors determining the emergence of socially
dangerous communication of teenagers on the Internet and leading to
deviations in the behavior of children. The purpose is to study the features of
interpersonal relationships of adolescents with computer addiction. To conduct
the study, we used the analysis and generalization of scientifi c literature
and psychodiagnostic methods as the scale of Internet addiction, Zhichkina
A.E. (into groups); the questionnaire “Perception of the Internet”, Shchepilina
E.A.; the method of diagnosing interpersonal relationships, T. Leary (adaptation
by L.N. Sobchik). To establish the reliability of the differences and
identify the relationships, the data were processed using descriptive statistics
methods. The subjects were  teenagers, aged from  to  years. According
to the results of the study, it can be concluded that the level of interpersonal
communication among adolescents tends to decline with increasing
dependence on the Internet, there are also features of self-acceptance and
dependence on the opinions of others. It was also found that teenagers who
are addicted to the Internet are more willing to take responsibility in decision-
making than teenagers who spend a moderate amount of time online.
Teenagers with Internet addiction have diffi culties in adapting, communicating
with their peers, because they are often withdrawn and shy, they are not
interested in engaging in social activities and do not want to make friends.
They also have signs of aggression that turn into antisocial behavior.
Sonographic evaluation of male anterior urethral strictures: Correlation with retrograde urethrography – A review
Authors: Samuel B  , Iya-Benson J
Published: November 2023

In general, the term urethral stricture refers to a fibrous scarring of the urethra caused by collagen and fibroblast proliferation.1-3 The scarring process can extend through the tissue of the corpus spongiosum into adjacent structures and this associated scarring in the surrounding corpus spongiosum is known as spongiofibrosis.1,4 Contraction of this scar reduces the width of the urethral lumen. Bulbar urethral strictures represent the overwhelming majority of cases, while prostatic urethral strictures are rare.5 The causes of anterior urethral strictures may be inflammatory (e.g., infectious urethritis, balanitis xerotica obliterans), traumatic (straddle injury, iatrogenic instrumentation) or congenital.1,6 However, most urethral strictures are the result of infection, instrumentation or other iatrogenic causes.1 The most common external cause of traumatic stricture is straddle injury.1,7 The male urethra is longer than that of the female and traverses through several anatomical structures such as the prostate, urogenital diaphragm, and corpus spongiosum of the penis, it is therefore more vulnerable to injury and stricture than the female urethra.1,8 Inflammatory strictures associated with gonococcal urethritis have become less common despite the fact that gonococcus remains the most common sexually transmitted disease.1 In developing countries, infection is the predominant cause of anterior urethral stricture, unlike in the developed world where trauma is the predominant cause.9-13 Iatrogenic trauma to the urethra may result from pressure necrosis at fixed points in the urethra from indwelling catheters.1 Instrumentation-related strictures usually occur in the bulbomembranous region and, less commonly, at the penoscrotal junction.1 Congenital hypospadias could be associated with urethral stricture, and following repair of hypospadias, there is an increased likelihood of post-surgical stricturing.14There is currently progressive increase in the incidence of urethral stricture due to the increased number of permanent catheter bearers, the surge of sexually transmitted diseases, and misuse of transurethral diagnostic or therapeutic instrumentation.1,6
Helpen behandelingen voor psychische stoornissen kinderen op de lange termijn?
Authors: Wienen Bert , De Jonge Peter , De Vries Ymkje Anna , Roest Annelieke
Published: November 2023

Verschillende instanties, waaronder gemeenten, worstelen met het vraagstuk van vroegdiagnostiek en vroege behandeling van kinderen. Moet je psychische stoornissen bij kinderen zo vroeg als mogelijk ‘vinden’ zodat je snel een diagnose kunt stellen en een behandeling kan starten? Dit lijkt een belangrijk beleidsuitgangspunt voor gemeenten; ‘vroeg erbij’ of ‘elke euro die je erin stopt, komt er op de lange termijn weer uit’. Op verzoek van een aantal gemeenten hebben we een wetenschappelijk literatuuronderzoek, een zogenaamde paraplu review, uitgevoerd naar wat er bekend is over de langetermijneffecten van behandelingen van de meest voorkomende stoornissen bij kinderen: ADHD, gedragsstoornissen, depressieve stoornissen en angststoornissen. We hebben alle beschikbare systematische reviews in de internationale literatuur op een rijtje gezet en op basis daarvan conclusies getrokken en aanbevelingen gedaan. Uit de paraplu review komt naar voren dat er geen overtuigend bewijs is dat interventies voor de meest voorkomende psychische stoornissen in kinderen een gunstige uitwerking hebben op de lange termijn (≥ 2 jaar). De wetenschappelijke literatuur kan daarom niet met zekerheid antwoorden geven op belangrijke vragen rondom het beleid van de gezondheidszorg aangaande de langetermijneffectiviteit en -veiligheid van behandelingen van psychische stoornissen in kinderen.
Ética y medicamentos
Authors: Peña Camarena Hugo
Published: November 2023

Utilizando los principios de la ética médica se analizaron las distintas fases del desarrollo de los medicamentos, encontrándose las siguientes faltas a la ética: uso inadecuado de fármacos en algunos ensayos clínicos en países en desarrollo, suspensión de la producción de medicamentos por falta de rentabilidad, información científica fraudulenta, manipulación de la información para favorecer la venta de ciertos productos farmacéuticos, promoción de medicamentos con folletos fraudulentos y la irresponsable publicidad de medicamentos en medios de información pública. Se proponen algunas alternativas de solución.
Cómo responder la pregunta de investigación. Elección del diseño de estudio adecuado
Authors: Padilla Ygreda Justo , Rojas Galarza Raúl , Lindo Pérez Felipe
Published: November 2023

La investigación se inicia con la observación. La idea de investigación puede ser originada de diversas fuentes y la calidad varía dependiendo de muchos factores. Una vez planteada la idea de investigación se debe definir el tipo de investigación a realizar.

Los estudios de investigación pueden ser clasificados de diferente forma. Pueden ser exploratorios, descriptivos, correlacionales y explicativos. Los diseños pueden ser descriptivos o analíticos y éstos últimos, observacionales o de intervención. Algunos ayudarán a generar hipótesis y otros ayudan a responderlas o corregirlas.

La selección del tipo de diseño de investigación dependerá del objetivo que se pretende conseguir con la realización de este.
Há respaldo para intervenções dietéticas nos transtornos psiquiátricos?
Authors: Torturella Igor Moreira , Okata Kelly Meyre Soares de Oliveira , Torturella Nilo Virgílio Gori , Alves Neto Celso , Peixer Carolina Malard , Aucélio João Pedro de Oliveira
Published: November 2023

Introdução: Funcionamento e composição do sistema nervoso central são dependentes da presença de macro e micronutrientes. Nesse sentindo, estudos demonstram que intervenções dietéticas apresentam resultados positivos em sintomas psiquiátricos. Tal fato, está relacionado à influência dos nutrientes nas funções cognitivas e no funcionamento cerebral. Objetivo: Descrever o impacto de intervenções dietéticas nos transtornos psiquiátricos. Métodos: revisão de literatura foi realizada com as palavras chaves “Macronutrients”, “Micronutrients”, “Mental health” e “Psychiatric Disorders” na base dados Pubmed e Science Direct. Foram utilizados artigos dos últimos 10 anos, nos idiomas inglês e português. Resultados: Na análise evidencia-se diversos mecanismos fisiopatológicos que sofrem influência de vitaminas e minerais no que tange o campo da saúde mental, como vitaminas do complexo B, vitamina D, ácidos graxos, zinco, magnésio, selênio e cálcio. Diversos estudos apresentam resultados positivos em indivíduos com sintomas de transtornos psicológicos, como depressão, TDAH e esquizofrenia, que realizaram a suplementação desses nutrientes, sendo que a suplementação em adultos saudáveis também apresenta benefícios sutis para sintomas de humor e ansiedade. Além disso, foram observados benefícios adicionais quanto ao uso de doses mais altas, acima da Ingestão Dietética Recomendada (Recommended Dietary Allowance - RDA). Conclusão: Os resultados demonstram que a prescrição baseada em nutrientes tem potencial auxiliador no manejo de transtornos psiquiátricos em nível individual e populacional, inclusive através de suplementações com dosagens acima da Ingestão Dietética Recomendada (RDA).
Nutrição e seu poder transformador na saúde mental
Authors: Torturella Nilo Virgílio Gori , Torturella Igor Moreira , Cunha Isabella de Almeida , Peixer Carolina Malard , Okata Kelly Meyre Soares de Oliveira , Alves Neto Celso
Published: November 2023

Introdução: Saúde mental compreende um importante aspecto da medicina atual e diversas evidências vêm associando a forte relação entre a alimentação e o bem-estar mental. Objetivo: Determinar o nível de evidência entre alimentação e saúde mental, visando a implementação de medidas alimentares para mitigar a exacerbação e o aparecimento de condições  neuropsiquiátricas, como uma prevenção primária. Metodologia: Revisão de literatura de artigos publicados nos últimos dez anos, utilizando as principais bases eletrônicas de dados, com publicações em inglês, português e espanhol. Foram utilizadas como palavras-chave “alimentação” e “saúde mental”. Resultados: Muitos estudos evidenciam que dietas ricas em polifenóis, gorduras poli-insaturadas e vitaminas associam-se com efeitos positivos na saúde mental, principalmente no humor, estresse, neuroinflamação e redução do risco de declínio cognitivo, principalmente em idosos. Notou-se que uma alimentação rica em gorduras e açúcares está relacionada a maior risco para manifestação de TDAH, bem como alimentos inflamatórios ao risco de depressão e ansiedade. Alguns estudos evidenciaram um menor risco de depressão à aderência da dieta mediterrânea, apresentando um efeito protetor ao desenvolvimento de possíveis transtornos. Ademais, o consumo de frutas e verduras relaciona-se com a redução do risco de déficit cognitivo e demência. Conclusão: O estabelecimento de uma dieta balanceada e saudável tem uma importante relevância na promoção de saúde mental no indivíduo de todas as idades, agindo como um fator protetivo.
Impacto negativo da alimentação na saúde mental
Authors: Torturella Nilo Virgílio Gori , Torturella Igor Moreira , Braz Juliana Vieira Torreão , Cunha Isabella de Almeida , Okata Kelly Meyre Soares de Oliveira , Alves Neto Celso
Published: November 2023

Introdução: O aumento dos casos de transtornos neuropsiquiátricos e o comprometimento da saúde mental representa um dos maiores desafios da saúde contemporânea. Porém, a maioria da população desconhece o impacto da alimentação na saúde mental.  Objetivo: Determinar o impacto nocivo de certos alimentos no desenvolvimento de transtornos neuropsiquiátricos, visando a mudança de padrões alimentares para a promoção da saúde mental. Metodologia: Revisão de literatura utilizando as principais bases eletrônicas de dados, utilizadas palavras-chave “alimentação” e “saúde mental”. Resultados: Estudos evidenciam que a gordura trans está relacionada a um maior risco de desenvolvimento da depressão1. Dietas ricas em frutose podem gerar um aumento dos comportamentos ansiosos e depressivos, e alterar os níveis de cortisol2. O consumo de bebidas com açúcar adicionado pode aumentar a prevalência de distúrbios mentais3, assim como alguns emulsificantes, como carboximetilcelulose e polissorbato-80, que alteram a microbiota intestinal e suas funções.4 Produtos ultraprocessados aumentam o risco de desenvolvimento de doenças crônicas não-transmissíveis e de sintomas de depressão e ansiedade5 devido às suas influências no sistema inflamatório, no estresse oxidativo e no microbioma intestinal6. Conclusão: O conhecimento dos efeitos nocivos de alguns alimentos e a implementação de uma dieta saudável tem influência direta sobre a saúde mental.
Serie histórica del Síndrome de Encefalopatía Posterior Reversible (PRES) en un hospital pediátrico de referencia nacional
Authors: Vélez Rosario , Benítez Andrea
Published: November 2023

El síndrome de encefalopatía posterior reversible (PRES) se considera una patología clínica-radiológica poco conocida. Se caracteriza por su presentación aguda o subaguda, de origen multifactorial. Entre sus manifestaciones clínicas predominan las neurológicas e hipertensión arterial. La resonancia magnética es el Gold estándar como método de diagnóstico en el que se puede observar afectación de la sustancia blanca, gris o ambas.

Metodología: Se efectuó un estudio descriptivo, retrospectivo, transversal de 23 casos de PRES del Hospital Pediátrico Roberto Gilbert Elizalde de enero 2013 a diciembre del 2022. Se recabaron variables sociodemográficas, epide- miológicas, clínicas y bioquímicas. Resultados: Se identificaron 23 pacientes con diagnóstico de PRES de los que 21 pacientes cumplieron los criterios de inclusión. El sexo femenino fue predominante con el 61.9 %, edad media de 9 a 17 años con el 66.8 %, las patologías asociadas fueron: lupus eritematoso, síndrome nefrótico, enfermedades hematológicas como leucemia mieloide y linfoblástica aguda con el 4.7 % respectivamente. Los fármacos relacionados fueron los inmunosupresores como levetircentam, prednisona, metilprednisolona, rituximab y tiroglobulina. En cuanto a los hallazgos de neuroimagen la lesión de sustancia blanca parieto-occipital fue la más frecuentemente descrita. Conclusión: La PRES se considera una entidad grave pero reversible con el adecuado abordaje y diagnóstico precoz por lo que el manejo precoz resulta fundamental para evitar daños irreversibles en el paciente pediátrico
Neuropatía periférica crónica como presentación de Síndrome de POEMS. Reporte de caso
Authors: Sabando Brenner , Amancha Margarita , Baño Viviana , Carpio Emily , Sarmiento Gabriela , Loor Yaira
Published: November 2023

El síndrome de POEMS es una variante poco frecuente de discrasia de células plasmáticas; la forma de presentación de esta enfermedad es variable, sin embargo, la polineuropatía es uno de los síntomas clave perteneciente a este síndrome. La neuropatía periférica se caracteriza por ser de inicio distal, simétrico y progresivo, durante un período de semanas a meses, que se deriva en debilidad muscular severa hasta limitación de la marcha. Presentamos a un paciente con polineuropatía sensitivo-motora de larga evolución, agregándose hipotiroidismo, lesiones en piel, banda monoclonal, organomegalia y lesiones osteoescleróticas en cuerpo vertebral, donde fue confirmado la infiltración de células plasmáticas otorgando el diagnóstico de Síndrome de POEMS.
Detectando lo inusual: nódulo de la hermana María José
Authors: Franco Heydi , Cuenca Luis Cuenca , Torres Cedeño Stefanie , Marquez Katherine Lozada
Published: November 2023

El nódulo de la hermana María José, una rareza médica, representa un hallazgo insólito en la región umbilical que puede indicar la presencia de una neoplasia intraabdominal maligna. Se reporta el caso de un paciente con antecedente patológico personal de gastritis crónica que luego del examen físico y métodos de diagnósticos, se identificó un adenocarcinoma gástrico con metástasis. El objetivo de este reporte es resaltar la necesidad de una exploración física minuciosa para la detección temprana y manejo oportuno en un contexto donde el pronóstico a menudo es desafiante.
ÇAĞDAŞ RESİM SANATINDA NEO-EKSPRESYONİZM EĞİLİMİ: IKB/ERBİL ÖRNEĞİ (1991-2015)
Authors: Othman Dana
Published: November 2023

Ekspresyonizm, bireyin ve toplumun trajik ve psikolojik durumlarının bir yansımasıdır. Irak'ın durumu ve bölgede yaşanan trajik olaylar, bu akım için iyi bir zemin olmuş ve sanatçılar bu eğilimde resim yapmaya yönelmiştir. İkinci dünya savaşından sonra dünyada ortaya çıkan ekspresyonist eğilimli eserler, Neo-Ekspresyonist bir sanat çerçevesinde değerlendirilmektedir. Bu araştırmada Erbil'deki Neo-Ekspresyonist Sanat'a eğilimli eserler ele alınmaya çalışılmıştır.
Bu araştırma, resim sanat tarihi çerçevesinde betimsel analiz yöntemine dayalı bir çalışmadır veErbil sanatçılarının 1991–2015 yılları arasında ürettikleri Neo-Ekspresyonizm resimlerini incelemektedir. Araştırmanın amacı, Erbil çağdaş sanatında Neo-Ekspresyonizm resimlerin özelliklerini ve temalarını keşfetmektir. Ayrıca, araştırmada Erbil çağdaş resminin tarihi ve Neo-Ekspresyonizm eserlerinin ortaya çıkışı da tartışılmıştır.
Erbilli sanatçıların kendi görsel ve biçimsel karakteristik özelliklerini kazanmaları bir süreç almıştır. Psikolojik boyutlar, Erbil Neo-Ekspresyonizmi'nde eserlerin yapımında temel bir rol oynamıştır. Neo-Ekspresyonizm akımının benimsediği gibi bazı farklı ve yerel özellikler Erbilli sanatçıların eserlerinde bulunmaktadır. Bütün özelliklere rağmen Erbilli sanatçıların Neo-Ekspresyonizmin genel prensipleri çerçevesinde kalmış oldukları ve bu üsluptan çıkamadıkları da belirtilebilir.
Després de Flordeneu. La fada modernista
Authors: Sunyer Magí
Published: November 2023

Aquest article examina la presència i la significació de les fades en la literatura modernista catalana. D’entrada, descarta els abundants personatges assimilables a les fades per via de metàfora, tant les dones-àngel com la versió negativa i perversa relacionada amb la prostitució i el vici. Un cop centrat en les fades d’origen folklòric, i després d’uns apartats contextualitzadors sobre la fada en el folklore, sobre la llegenda en el Modernisme català i sobre el poema Canigó, de Jacint Verdaguer, s’hi analitza el tema central de l’estudi. Llavors s’observa que, des d’estètiques i plantejaments diferents, les tres caracteritzacions bàsiques del personatge són la fada seductora d’homes, les que se simbolitzen com a esperits de la natura i, dintre d’aquestes darreres, les que formen part de textos que enfoquen la qüestió des d’un plantejament ecologista.
Enric Querol Coll, 'Cultura i lletres a Tortosa (1700-1821). Llums i contrallums', Benicarló, Onada Edicions, 2022, 255 p.
Authors: Sogues Marco Marc
Published: November 2023

Ressenya sobre el llibre d'Enric Querol Coll, Cultura i lletres a Tortosa (1700-1821). Llums i contrallums, Benicarló, Onada Edicions, 2022, 255 p., ISBN: 978-84-18634-80-2.
Gabriel Garcia Frasquet, «El teatre valencià (1845-1945). La rellevància de les actrius», València, Institut Interuniversitari de Filologia Valenciana / Institució Alfons el Magnànim - Centre Valencià d’Estudis i d’Investigació, 2022, 386 p.
Authors: Gallén Enric
Published: November 2023

Ressenya sobre el llibre de Gabriel Garcia Frasquet, El teatre valencià (1845-1945). La rellevància de les actrius, València, Institut Interuniversitari de Filologia Valenciana / Institució Alfons el Magnànim - Centre Valencià d’Estudis i d’Investigació, 2022, 386 p., ISBN: 978-84-7822-939-0.
VI Almanzora Comparte: cooperación, conocimiento y corazón
Authors: Sanz Martos Sandra
Published: November 2023

El pasado 19 de octubre tuvo lugar la VI edición de la Jornada Almanzora Comparte, la tercera en formato hackathon. La Escuela del mármol de Fines, centro de referencia nacional y excelente anfitriona, volvió a acoger a medio centenar de agentes clave de la comarca del Almanzora en los ámbitos institucional, empresarial y social para intercambiar ideas y experiencias, identificar oportunidades y realizar propuestas para impulsar esta región.
Full-atomistic molecular dynamics analysis of p53 active tetramer
Authors: Zhou Han , Geng Yi-Zhao , Yan Shi-Wei ,   Department of Physics, Beijing Normal University, Beijing 100875, China,   Faculty of Science, Hebei University of Technology, Tianjin 300131, China,   Faculty of Arts and Sciences, Beijing Normal University, Zhuhai 519085, China
Published: November 2023

p53 is a tumor suppressor protein that plays a crucial role in inhibiting cancer development and maintaining the genetic integrity. Within the cell nucleus, four p53 molecules constitute a stable tetrameric active structure through highly cooperative interactions, bind to DNA via its DNA-binding domain, and transcriptionally activate or inhibit their target genes. However, in most human tumor cells, there are numerous p53 mutations. The majority of these mutations are formed in the p53 DNA-binding domain, importantly, the p53 DNA-binding domain is critical for p53 to form the tetrameric active structures and to regulate the transcription of its downstream target genes. In this work, the all-atom molecular dynamics simulation is conducted to investigate the mechanism of interaction within the wild-type p53 tetramers. This study indicates that the symmetric dimers on either side of the DNA are stable ones, keeping stable structures before and after DNA binding. The binding of two monomers on the same side of the DNA depends on protein-protein interaction provided by two contact surfaces. DNA scaffold stabilizes the tetrameric active structure. Such interactions crucially contribute to the tetramer formation. This study clarifies the internal interactions and key residues within the p53 tetramer in dynamic process, as well as the critical sites at various interaction interfaces. The findings of this study may provide a significant foundation for us to further understand the p53’s anticancer mechanisms, to explore the effective cancer treatment strategies, and in near future, to develop the effective anti-cancer drugs.
Catecholaminergic neuromodulation and selective attention jointly shape perceptual decision-making
Authors: Nuiten Stijn A. , De Gee Jan Willem , Zantvoord Jasper B. , Fahrenfort Johannes J. , van Gaal Simon
Published: November 2023

Perceptual decisions about sensory input are influenced by fluctuations in ongoing neural activity, most prominently driven by attention and neuromodulator systems. It is currently unknown if neuromodulator activity and attention differentially modulate perceptual decision-making and/or whether neuromodulatory systems in fact control attentional processes. To investigate the effects of two distinct neuromodulatory systems and spatial attention on perceptual decisions, we pharmacologically elevated cholinergic (through donepezil) and catecholaminergic (through atomoxetine) levels in humans performing a visuo-spatial attention task, while we measured electroencephalography (EEG). Both attention and catecholaminergic enhancement improved decision-making at the behavioral and algorithmic level, as reflected in increased perceptual sensitivity and the modulation of the drift rate parameter derived from drift diffusion modeling. Univariate analyses of EEG data time-locked to the attentional cue, the target stimulus, and the motor response, further revealed that attention and catecholaminergic enhancement both modulated pre-stimulus cortical excitability, cue- and stimulus-evoked sensory activity as well as parietal evidence accumulation signals. Interestingly, we observed both similar, unique, and interactive effects of attention and catecholaminergic neuromodulation on these behavioral, algorithmic, and neural markers of the decision-making process. Thereby, this study reveals an intricate relationship between attentional and catecholaminergic systems and advances our understanding about how these systems jointly shape various stages of perceptual decision-making.
RIM-BP2 is required for rapid neurotransmitter release through regulation of Ca2+ channel clustering at hippocampal mossy fiber terminals
Authors: Miyano Rinako , Sakamoto Hirokazu , Hirose Kenzo , Sakaba Takeshi
Published: November 2023

Synaptic vesicles dock and fuse at the presynaptic active zone (AZ), the specialized site for transmitter release. AZ proteins play multiple roles such as recruitment of Ca
2+
channels as well as synaptic vesicle docking, priming and fusion. However, the precise role of each AZ protein type remains unknown. At phasic synapses having high release probability, Rab3-interacting molecule-binding protein2 (RIM-BP2) is known to affect Ca
2+
channel localization at AZs. In order to dissect the role of RIM-BP2 at tonic synapses having low release probability, we applied electrophysiological recording and super-resolution imaging to hippocampal mossy fiber terminals of RIM-BP2 KO mice. By using whole cell capacitance measurements, we found that reduced Ca
2+
currents were responsible for the decreased rates of transmitter release in RIM-BP2 KO terminals. Consistently, STED microscopy pictured lower densities of P/Q-type Ca
2+
channels at AZs deficient in RIM-BP2. Our results suggest that the RIM-BP2 function differs between phasic and tonic synapses.
A novel metabolism-related gene signature in patients with hepatocellular carcinoma
Authors: Ru Bin , Hu Jiaqi , Zhang Nannan , Wan Quan
Published: November 2023

Hepatocellular carcinoma (HCC) remains a global challenge as it is the sixth most common neoplasm worldwide and the third leading cause of cancer-related death. A key feature of HCC is abnormal metabolism, which promotes cancer cell proliferation, survival, invasion, and metastasis. However, the significance of metabolism-related genes (MRGs) in HCC remains to be elucidated. Here, we aim to establish a novel metabolism-related prognostic signature for the prediction of patient outcomes and to investigate the value of MRG expression in the prognostic prediction of HCC. In our research, a Metabolism-Related Risk Score (MRRS) model was constructed using 14 MRGs (DLAT, SEPHS1, ACADS, UCK2, GOT2, ADH4, LDHA, ME1, TXNRD1, B4GALT2, AK2, PTDSS2, CSAD, and AMD1). The Kaplan-Meier curve confirmed that the MRRS has a high accuracy in predicting the prognosis of HCC patients (p < 0.001). According to the MRRS model, the area under the curve (AUC) values for predicting the prognosis of patients with hepatocellular carcinoma at 1, 3, and 5 years reached 0.829, 0.760, and 0.739, respectively. Functional analyses revealed that signaling pathways associated with the cell cycle were largely enriched by differential genes between high and low-risk groups. In addition, dendritic cells (DCs) (p < 0.001), CD4+ T cells (p < 0.01), CD8+ T cells (p < 0.001), B cells (p < 0.001), neutrophils (p < 0.001), macrophages (p < 0.001) had a higher proportion of infiltrates in high-risk populations. Low GOT2 expression is associated with poor prognosis in patients with hepatocellular carcinoma. Knockdown of GOT2 significantly increased the migration capacity of the Huh7 and MHCC97H hepatocellular carcinoma lines. Our research reveals that GOT2 is negatively related to the survival of patients with hepatocellular carcinoma and GOT2 may contribute to tumor progression by inhibiting the ability of tumor cells to migrate.
On the morphological variations in a population of Cladonema radiatum (Hydrozoa: Cladonematidae): New evidence from the southern Gulf of Mexico
Authors: Ahuatzin-Hernández José María , Canul-Cabrera Jesús Andrés , Ordóñez-López Uriel , León-Deniz Lorena Violeta
Published: November 2023

The lack of knowledge on the morphological variability in hydrozoan populations has resulted in numerous misidentifications over history. Cladonema radiatum Dujardin, 1843 is characterized by presenting different morphologies in different localities of the world, which has caused many taxonomic confusions within the group. In this study, the morphological variability in a population of C. radiatum is analyzed. The material came from a coastal lagoon in the southern Gulf of Mexico. The samplings were carried out for 3 months in 2017. Salinity, dissolved oxygen, and temperature were recorded at each sampling site. Cladonema radiatum was more abundant and bigger when the lagoon showed the lowest levels of salinity. Six different morphologies were recognized. The presence of gelatinous papillae on the abaxial surface of marginal bulbs and an abaxial arrangement of nematocysts in the shortest branches of the tentacles are features recorded for the first time in the species. These considerations enrich the taxonomic description of C. radiatum and contribute to the knowledge on the taxonomy of Hydrozoa in Mexico. The taxonomy of Cladonema continues to be confusing, and the present work sets a basis for further integrative studies clarifying the morphological boundaries of the genus. However, only integrative works based on the morphology and molecular analyses of the species would be able to decode its cryptic nature.
ICTs and Smart Agriculture in Bangladesh: Way of Sustainable Development
Authors: Ahmed Mustak , Raha Sabrina Mehreen
Published: November 2023

This paper analyzes how the farmers of Bangladesh use the modern technology of information and communication for gathering different agricultural data. Farmers of Bangladesh are being encouraged to use smart devices of information and technology such as smart phones, android phones, laptops, desktops, electronic television for getting updates on different agricultural products, harvesting, and competitive markets. Information and communication technology includes all the devices with inbuilt human to human and device to human interaction systems. Thus, information and technology have a direct and indirect impact on rising farmers’ productivity and growth for sustainable management. This study sheds light on the understanding of the effect of information and communication technology in agricultural growth of Bangladesh for sustainable development with the help of conclusive research design and secondary method of data collection has adopted in this research for understanding of the importance of using information and technology in smart agriculture.
Assessing the Awareness, Attitude and Practice of Liquefied Petroleum Gas Station Workers to Fire Emergency Response in Ikotun, Lagos, Nigeria
Authors: Ekong Akaninyene Edet , Michael Ogunbanwo Babatunde
Published: November 2023

The incidents of fire associated with Liquefied Petroleum Gas (LPG) has been on a rampage, particularly since it has become a popular alternative to other energy sources. The study assessed the impact of level of awareness on attitude and practice of gas station workers on fire emergency. The Swiss cheese model was used to underpin the work. The study utilised a descriptive research design. The sample size was 60 managements and non-management staff from 5 LPG stations in Ikotun, Lagos. Data was collected by means of questionnaire. The data was analysed using descriptive statistics which is frequency and percentage; inferential statistics used includes Chi Square and Bivariate Correlation. The result revealed the following: There is no relationship between the level of awareness and the attitude of the gas stations’ workers on fire emergency; There is relationship between the level of awareness and the practice of the gas stations’ workers on fire emergency. The study recommended that management should spell out rules and policies to guide workers’ attitude and practice towards fire emergency and state punishment for gas workers whose practices are contrary to the policies of the organisation. Management should conduct regular fire emergency training to ensure increased awareness among staff.
A SMOOTH DIFFUSION RATE MODEL OF WOOD DRYING:A SIMULATION TOWARD MORE EFFICIENT PROCESS IN INDUSTRY
Authors: Cahyono Edi , Soeharyadi Yudi , Mukhsar Mukhsar
Published: November 2023

In this paper we consider modeling of wood drying process in an industry. The process is conducted in a kiln oven. Mathematically, the drying inside the wood is considered as an initial and boundary value problem. The model is a diffusion equation where the diffusion rate depends on the moisture content of the wood. We investigate a smooth diffusion rate and we compare the model with real data from an industry. The model shows a good agreement with the real data. Moreover, the model shows a smoother process of drying, which is more desirable by the timber and lumber industries to improve their current methods of drying.
Sistem Supply Chain Crude-Palm-Oil Indonesia dengan Mempertimbangkan Aspek Economical Revenue, Social Welfare dan Environment
Authors: Widodo Kuncoro Harto , Abdullah Aang , Dwi Arbita Kharies Pramudya
Published: November 2023

Crude-Palm-Oil (CPO) is an agro-industrial commodity which has a strategic value to be developed for Indonesian economy and social welfare. Production and export of Indonesian CPO increase progressively in the view years so that CPO is one of the pre-eminent products of Indonesia. On the other hand, however, they could give two negative impacts. First, a less CPO supply for domestic market as a result of export growing. Second, a worse environment as an effect of the opening new palm plantations. We, therefore, construct and simulate the system model for analyzing the relationships between the components and for describing their behaviour within the supply chain of CPO by using a dynamic model. The result shows that in the next 30 years, the revenue of Indonesian CPO industries tends to increase. The biggest revenue will be achieved in the year 23rd. The maximum addition of plantation employees is in the year 7th as well as in the year 17th. Deforestation would be the highest in the year 7th and 17th in which 2008 as a basic year.
A MULTI CRITERIA APPROACH TO DESIGNING THE CELLULAR MANUFACTURING SYSTEM
Authors: Hadiguna Rika Ampuh
Published: November 2023

Cellular manufacturing system design problems such as design framework, manufacturing cells layout and layout evaluation. The research objective is developing the framework to designing manufacturing cells with considering the organization and management aspects in shopfloor. In this research have compared the existing layout with proposed layout which applied the multi criteria approach. The proposed method is combining Analytical Hierarchy Process (AHP), Clustering and heuristic approach. The result has show that grouping with Single Linkage Clustering (SLC) to be selected as manufacturing cells. The comparison of clustering weight is 0,567, 0,245 and 0,188 for SLC, Complete Linkage Clustering (CLC) and Average Linkage Clustering (ALC), respectively. This result shows that generating layout by using grouping result from SLC. The evaluation result shows that types of manufacturing cells better than process layout which used the existing system.
A REPLENISHMENT POLICY FOR ITEM WITH PRICE DEPENDENT DEMAND AND DETERIORATING UNDER MARKDOWN POLICY
Authors: Wee Hui Ming , Widyadana Gede Agus
Published: November 2023

Many researches on deteriorating inventory model have been developed in recent years. This paper develops deteriorating inventory model with price-dependent demand and uses markdown policy to increase profit. Two examples are used to explain the model and some interesting results are derived. Markdown policy can increase total profit, but the best markdown time and price depend are case dependent.
Construction and application of milk-feed price ratio model - based on data from large scale dairy farms in China
Authors: Liu Hao , Peng Hua , Zhang Chao , Dong Xiaoxia
Published: November 2023

Despite rapid development, the Chinese dairy industry still faces problems such as the lack of pricing power for dairy farmers, high fluctuations in raw milk and feed prices, imbalances between supply and demand, and low farming motivation. As an indicator with important geographical characteristics, the milk-feed price ratio (MF) is a critical reference indicator for setting raw milk prices and measuring farm profitability. The main aim of this study is to construct an appropriate milk-feed ratio model for China using statistical data for 2018-2020, which provides references for other developing countries. A vector error correction model was used to illustrate the long-term covariance between raw milk prices and feed prices in China and to analyze the feed structure of large-scale Chinese farms. The study found that the price weights of corn, soybean meal, corn silage, and alfalfa were 27%, 17%, 30%, and 26%, respectively, which are significantly different from those of developed countries, and the parameters of the model for the MF in different production areas in China also varied significantly. The milk-feed ratio in China has remained above 1.89 in the last three years. Seasonal variations in raw milk prices lead to a U-shaped trend in the MF. In recent years the MF in China has changed from a low level to a medium level, showing an upward trend, with large-scale farms at a profitable level.

Keywords: Application of MF; Granger causality test; MF model; Large scale farm