bluuebunny/crossref_metadata_2025 huggingface dataset:
A Label-Free Fluorescent Sensor Based on the Formation of Poly(thymine)-Templated Copper Nanoparticles for the Sensitive and Selective Detection of MicroRNA from Cancer Cells
Authors: Ma Qian , Gao Zhiqiang , Dayal Hiranya , Li Sam Fong Yau
Published: July 2020

In this work, a simple and label-free fluorescence “off” to “on” platform was designed for the sensitive and selective detection of microRNA (miRNA) in cancer cells. This method utilized a padlock DNA-based rolling circle amplification (P-RCA) to synthesize fluorescent poly(thymine) (PolyT) which acted as a template for the synthesis of copper nanoparticles (CuNPs) within 10 minutes under mild conditions. While the repeated PolyT sequence was used as the template for CuNP synthesis, other non-PolyT parts (single strand-DNAs without the capacity to act as the template for CuNP formation) served as “smart glues” or rigid linkers to build complex nanostructures. Under the excitation wavelength of 340 nm, the synthesized CuNPs emitted strong red fluorescence effectively at 620 nm. To demonstrate the use of this method as a universal biosensor platform, lethal-7a (let-7a) miRNA was chosen as the standard target. This sensor could achieve highly sensitive and selective detection of miRNA in the presence of other homologous analogues for the combination of P-RCA with the fluorescent copper nanoparticle. Overall, this novel label-free method holds great potential in the sensitive detection of miRNA with high specificity in real samples.
Guided Endodontic Treatment of Calcified Lower Incisors: A Case Report
Authors: Ishak Georges , Habib Marc , Tohme Hani , Patel Shanon , Bordone Antonietta , Perez Cyril , Zogheib Carla
Published: July 2020

A 52-year-old female patient was diagnosed with chronic periapical periodontitis associated with severely calcified lower central incisors. Radiographic examination revealed no visible root canal in the coronal-third of the root. After choosing the guided endodontic treatment, an intraoral scan (Trios, 3shape, Copenhagen, Denmark), in conjunction with a cone beam computed tomography (CBCT) scan, was taken in order to design and fabricate a printed guide. Virtual implant software was used to visualize the surgical access into the sclerosed root canals. After locating the canals, the guide was removed, and the teeth were treated under a rubber dam. The guided approach allows predictable, efficient endodontic treatment of teeth presenting calcified canals, with minimal removal of sound dentine and less risk of root perforations.
Constructing of Digital Watermark Based on Generalized Fourier Transform
Authors: Dronyuk Ivanna , Fedevych Olga , Kryvinska Natalia
Published: July 2020

We develop in this paper a method for constructing a digital watermark to protect one-dimensional and two-dimensional signals. The creation of a digital watermark is based on the one-dimensional and two-dimensional generalized Fourier and Hartley transformations and the Ateb-functions as a generalization of trigonometric functions. The embedding of the digital watermark is realized in the frequency domain. The simulation of attacks on protected files is carried out to confirm the stability of the proposed method. Experiments proved the high stability of the developed method conformably to the main types of attacks. An additional built-in digital watermark can be used to identify protected files. The proposed method can be used to support the security of a variety of signals—audio, images, electronic files etc.—to protect them from unauthorized access and as well for identification.
A Novel Probabilistic Power Flow Algorithm Based on Principal Component Analysis and High-Dimensional Model Representation Techniques
Authors: Li Hang , Zhang Zhe , Yin Xianggen
Published: July 2020

Because the penetration level of renewable energy sources has increased rapidly in recent years, uncertainty in power system operation is gradually increasing. As an efficient tool for power system analysis under uncertainty, probabilistic power flow (PPF) is becoming increasingly important. The point-estimate method (PEM) is a well-known PPF algorithm. However, two significant defects limit the practical use of this method. One is that the PEM struggles to estimate high-order moments accurately; this defect makes it difficult for the PEM to describe the distribution of non-Gaussian output random variables (ORVs). The other is that the calculation burden is strongly related to the scale of input random variables (IRVs), which makes the PEM difficult to use in large-scale power systems. A novel approach based on principal component analysis (PCA) and high-dimensional model representation (HDMR) is proposed here to overcome the defects of the traditional PEM. PCA is applied to decrease the dimension scale of IRVs and eliminate correlations. HDMR is applied to estimate the moments of ORVs. Because HDMR considers the cooperative effects of IRVs, it has a significantly smaller estimation error for high-order moments in particular. Case studies show that the proposed method can achieve a better performance in terms of accuracy and efficiency than traditional PEM.
Musculoskeletal Complaints in Occupational Therapists Compared to the General Population: A Cross-Sectional Study in Germany
Authors: Zenker Ronny , Girbig Maria , Hegewald Janice , Gilewitsch Irina , Wagner Mandy , Nienhaus Albert , Seidler Andreas
Published: July 2020

Occupational therapists (OTs) are exposed to physical factors at work, which can lead to an increased risk of musculoskeletal disorders. Most studies examining musculoskeletal complaints in OT report that the neck, shoulders, and lower back are most often afflicted. The aim of the present study was to examine the impact of work as an OT (focusing on specific work tasks) on specific musculoskeletal complaints compared to the general working population. A cross-sectional study involving a self-administered standardized questionnaire was conducted from January until October 2015 in Germany. In OT and the comparison group, the highest 12-month prevalence of musculoskeletal disorders were observed for the lower back, the neck, and the shoulders. In contrast, elevated prevalence ratios (PR) were found for OT in the thumbs (PR = 2.7; 95% CI = 1.9–3.8), the wrists (PR = 1.4; 95% CI = 1.1–1.8), and the elbows (PR = 1.5; 95% CI = 1.0–2.2). OTs were particularly exposed to high exertion hand activity and several stressful postures at work. In conclusion, OTs seem to be at risk of developing work-related musculoskeletal complaints in the thumbs, wrists, and elbows. Preventive measures should help to reduce the exposures caused by highly repetitive and forceful hand activities.
Adapting Citizen Science to Improve Health in an Occupational Setting: Preliminary Results of a Qualitative Study
Authors: van den Berge Mandy , Hulsegge Gerben , van der Molen Henk F. , Proper Karin I. , Pasman H. Roeline W. , den Broeder Lea , Tamminga Sietske J. , Hulshof Carel T. J. , van der Beek Allard J.
Published: July 2020

Health interventions often do not reach blue-collar workers. Citizen science engages target groups in the design and execution of health interventions, but has not yet been applied in an occupational setting. This preliminary study determines barriers and facilitators and feasible elements for citizen science to improve the health of blue-collar workers. The study was conducted in a terminal and construction company by performing semi-structured interviews and focus groups with employees, company management and experts. Interviews and focus groups were analyzed using thematic content analysis and the elements were pilot tested. Workers considered work pressure, work location and several personal factors as barriers for citizen science at the worksite, and (lack of) social support and (negative) social culture both as barriers and facilitators. Citizen science to improve health at the worksite may include three elements: (1) knowledge and skills, (2) social support and social culture, and (3) awareness about lifestyle behaviors. Strategies to implement these elements may be company specific. This study provides relevant indications on feasible elements and strategies for citizen science to improve health at the worksite. Further studies on the feasibility of citizen science in other settings, including a larger and more heterogeneous sample of blue-collar workers, are necessary.
Evaluation of the Suitability of an Existing Job–Exposure Matrix for the Assessment of Exposure of UK Biobank Participants to Dust, Fumes, and Diesel Exhaust Particulates
Authors: Dimakakou Eirini , Johnston Helinor J. , Streftaris George , Cherrie John W.
Published: July 2020

Many epidemiological studies have shown an association between outdoor particulate air pollutants and increased morbidity and mortality. Inhalation of ambient aerosols can exacerbate or promote the development of cardiovascular and pulmonary diseases as well as other diseases, such as type 2 diabetes mellitus (T2DM) and neurodegenerative diseases. Occupational exposure to dust, fumes and diesel exhaust particulates can also cause adverse health outcomes and there are numerous occupations where workers are exposed to airborne particles that are similar to ambient air pollution. An individual’s job title has normally been identified as a major determinant of workplace exposure in epidemiological studies. This has led to the development of Job–Exposure Matrices (JEMs) as a way of characterising specific workplace exposures. One JEM for airborne chemical exposures is the Airborne Chemical Exposure Job–Exposure Matrix (ACE JEM), developed specifically for the UK Biobank cohort. The objective of this paper is to evaluate the suitability of the ACE JEM in assessing occupational aerosol exposure of participants in the UK Biobank. We searched the scientific literature to identify exposure data linked to selected jobs in the ACE JEM and compared these data with the JEM assessments. Additionally, we carried out an independent expert-based assessment of exposure to compare with the JEM estimates. There is good published evidence to substantiate the high dust and biological dust assignments in the JEM and more limited evidence for diesel exhaust particulates. There is limited evidence in the published literature to substantiate moderate or low exposure assignments in the JEM. The independent expert-based assessment found good agreement at the two extremes of exposure in the JEM (high and no exposure), with uncertainty in all other classifications. The ACE JEM assignments are probably reliable for highly exposed jobs and for jobs assigned as unexposed. However, the assignments for medium and low exposures are less reliable. The ACE JEM is likely to be a good tool to examine associations between occupational exposures to particulates and chronic disease, although it should be used with caution. Further efforts should be made to improve the reliability of the ACE JEM.
“A Woman Is a Puppet.” Women’s Disempowerment and Prenatal Anxiety in Pakistan: A Qualitative Study of Sources, Mitigators, and Coping Strategies for Anxiety in Pregnancy
Authors: Rowther Armaan A , Kazi Asiya K , Nazir Huma , Atiq Maria , Atif Najia , Rauf Nida , Malik Abid , Surkan Pamela J
Published: July 2020

Common mental disorders are highly prevalent among pregnant women in low- and middle-income countries, yet prenatal anxiety remains poorly understood, particularly in the sociocultural context of South Asia. Our study explored sources, mitigators, and coping strategies for anxiety among symptomatic pregnant women in Pakistan, particularly in relation to autonomy in decision-making and social support. We interviewed 19 pregnant married women aged 18–37 years recruited from 2017–2018 at a public hospital in Rawalpindi who screened positive for anxiety. Thematic analysis was based on both inductive emergent codes and deductive a priori constructs of pregnancy-related empowerment. Gender norms emerged as an important dimension of Pakistani women’s social environment in both constraining pregnancy-related agency and contributing to prenatal anxiety. Women’s avenues of self-advocacy were largely limited to indirect means such as appeals to the husband for intercession or return to her natal home. The levels of autonomy during pregnancy depended on the area of decision-making, and peer/family support was a critical protective factor and enabling resource for maternal mental health. Women’s disempowerment is a key contextual factor in the sociocultural experience of prenatal maternal anxiety in South Asia, and further examination of the intersections between empowerment and perinatal mental illness might help inform the development of more context-specific preventive approaches.
Integrated 3D Information for Custom-Made Bone Grafts: Focus on Biphasic Calcium Phosphate Bone Substitute Biomaterials
Authors: Giuliani Alessandra , Gatto Maria Laura , Gobbi Luigi , Mangano Francesco Guido , Mangano Carlo
Published: July 2020

Purpose: Several studies showed that the sintering temperature of 1250 °C could affect the formation of α-Ca3(PO4)2, which is responsible for the reduction of the hardness value of biphasic calcium phosphate biocomposites, but they did not evaluate the inference of the sintering time at peak temperature on transition of β-Ca3(PO4)2 to α-Ca3(PO4)2. This analysis explored, in an innovative way, inferences and correlations between volumetric microstructure, mechanical properties, sintering temperature, and time at peak temperature in order to find the best sintering conditions for biphasic calcium phosphate composites grafted in severe alveolar bone defects. Methods: Sintered biphasic calcium phosphates (30%-hydroxyapatite/70%-tricalcium phosphate) were tested by microCT imaging for the 3D morphometric analysis, by compressive loading to find their mechanical parameters, and by X-ray diffraction to quantify the phases via Rietveld refinement for different sintering temperatures and times at the peak temperature. Data were analysed in terms of statistical inference using Pearson’s correlation coefficients. Results: All the studied scaffolds closely mimicked the alveolar organization of the jawbone, independently on the sintering temperatures and times; however, mechanical testing revealed that the group with peak temperature, which lasted for 2 hours at 1250 °C, showed the highest strength both at the ultimate point and at fracture point. Conclusion: The good mechanical performances of the group with peak temperature, which lasted for 2 hours at 1250 °C, is most likely due to the absence of the α-Ca3(PO4)2 phase, as revealed by X-ray diffraction. However, we detected its presence after sintering at the same peak temperature for longer times, showing the time-dependence, combined with the temperature-dependence, of the β-Ca3(PO4)2 to α-Ca3(PO4)2 transition.
The Impacts of International Political and Economic Events on Japanese Financial Markets
Authors: Sultonov Mirzosaid
Published: July 2020

Information about the possibilities of changes in national and international macroeconomic variables affects the expectations and behavior of individuals and firms more quickly than real changes in those macroeconomic variables. In this research, we investigate the impacts of international information (news) on the financial markets in Japan. We examine how news about the results of the Brexit referendum (BR) and the United States presidential election (USE) affected foreign exchange rates and stock market indexes. This research reveals evidence of statistically significant changes in exchange rates and stock market indexes within two weeks after the BR and USE, statistically significant changes in the exchange rate variance within the first week after the BR, and changes in the causality relationship between the variables after each event.
Spatial Data Science
Authors: Bacao Fernando , Santos Maribel Yasmina , Behnisch Martin
Published: July 2020

The field of data science has had a significant impact in both academia and industry, and with good reason [...]
Innate Biomineralization
Authors: Tian Erming , Watanabe Fumiya , Martin Betty , Zangari Maurizio
Published: July 2020

In vertebrates, biomineralization is a feature considered unique to mature osteoblasts and odontoblasts by which they synthesize hydroxyapatite (HAP), which is deposited in the collagen matrix to construct endoskeleton. For many decades, the mechanisms that modulate differentiation and maturation of these specialized cells have been sought as a key to understanding bone-remodeling defects. Here, we report that biomineralization is an innate ability of all mammalian cells, irrespective of cell type or maturation stage. This innate biomineralization is triggered by the concomitant exposure of living cells to three indispensable elements: calcium ion, phosphoester salt, and alkaline phosphatase. Any given somatic cell, including undifferentiated mononuclear cells, can undergo a biomineralization process to produce calcium-phosphate agglomerates. The biologically generated minerals under such conditions are composed of genuine HAP crystallites of Ca10(PO4)6(OH)2 and 5–10 nanometer (nm) in size. This discovery will profoundly improve our understanding of bone metabolism and ectopic calcifications.
Anti-Metastatic Effects of Plant Sap-Derived Extracellular Vesicles in a 3D Microfluidic Cancer Metastasis Model
Authors: Kim Kimin , Jung Jik-Han , Yoo Hye Ju , Hyun Jae-Kyung , Park Ji-Ho , Na Dokyun , Yeon Ju Hun
Published: July 2020

Natural medicinal plants have attracted considerable research attention for their potential as effective drugs. The roots, leaves and stems of the plant, Dendropanax morbifera, which is endemic to southern regions of Asia, have long been used as a folk medicine to treat variety of diseases. However, the sap of this plant has not been widely studied and its bioactive properties have yet to be clearly elucidated. Here, we isolated extracellular vesicles from D. morbifera sap with the goal of improving the intracellular delivery efficiency and clinical effectiveness of bioactive compounds in D. morbifera sap. We further investigated the anti-metastatic effects of D. morbifera sap-derived extracellular vesicles (DMS-EVs) using a cancer metastasis model based on 3D microfluidic system that closely mimics the in vivo tumor environment. We found that DMS-EVs exerted a concentration-dependent suppressive effect on cancer-associated fibroblasts (CAFs), which are important mediators of cancer metastasis. DMS-EVs also altered expression level of genes, especially growth factor and extracellular matrix (ECM)-related genes, including integrin and collagen. Our findings suggest that DMS-EVs can act as anti-CAF agents to reduce CAFs in the tumor microenvironment. They further indicate the utility of our 3D microfluidic model for various drug-screening assays as a potential alternative to animal testing for use in validating therapeutic effects on cancer metastasis.
Evolution and Structure of the Kuroshio Extension Front in Spring 2019
Authors: Wang Jiahao , Mao Kefeng , Chen Xi , Zhu Kelan
Published: July 2020

Satellite data products and high-resolution in situ observations were combined to investigate the evolution and structure of the Kuroshio Extension Front in Spring 2019. The former reveals the variation of the front is influenced by the northward movement of the Kuroshio Extension through transporting warm and saline water to a cold and brackish water region. The latter indicates steep upward slopes of the isopycnals, tilting northward in the frontal zone, as well as several ~300 m thick blobs of North Pacific Intermediate Water between 26.25 and 26.75 kg/m3, where conspicuous thermohaline intrusions occur. Further analysis indicates these thermohaline intrusions prefer to alternate salt fingering and diffusive convection interfaces, and are affected by strong shears.
In Vitro Interaction between Isavuconazole and Tacrolimus, Cyclosporin A, or Sirolimus against Aspergillus Species
Authors: Schwarz Patrick , Dannaoui Eric
Published: July 2020

The interaction of isavuconazole with immunosuppressors (tacrolimus, cyclosporin A, or sirolimus) against 30 Aspergillus isolates belonging to the most common species responsible for invasive aspergillosis in humans (Aspergillus flavus, Aspergillus fumigatus, Aspergillus nidulans, Aspergillus niger, and Aspergillus terreus) was evaluated in vitro by a microdilution checkerboard technique based on the EUCAST reference method for antifungal susceptibility testing. The interpretation of the results was performed based on the fractional inhibitory concentration index. The combination of isavuconazole with tacrolimus, cyclosporin A, or sirolimus, was synergistic for 56, 20, or 10% of the isolates, respectively. Interestingly synergy of the combination of isavuconazole with tacrolimus was also achieved for the majority of azole-resistant isolates of A. fumigatus, and for all A. niger isolates with isavuconazole minimal inhibitory concentrations ≥ 8 µg/mL. Antagonistic interactions were never observed for any combination tested.
Use of Nanomaterials in the Stabilization of Expansive Soils into a Road Real-Scale Application
Authors: Rosales Julia , Agrela Francisco , Marcobal José Ramón , Diaz-López José Luis , Cuenca-Moyano Gloria M. , Caballero Álvaro , Cabrera Manuel
Published: July 2020

Stabilization is a traditional strategy used to improve soils with the main objective of ensuring that this base is compliant with the technical specifications required for the subsequent development of different infrastructures. This study proposes the use of commercial nanomaterials, based on a solution of silicates, to improve the technical characteristics and bearing capacity of the expansive soil. A physical–chemical property study was carried out on the additive nanomaterial. Subsequently, different mixtures of expansive soil, selected soil and artificial gravel with quicklime and commercial nanomaterials were developed to evaluate the improvement obtained by the use of nanomaterials in the technical characteristics of the soil. Compressive strength and the Californian Bearing Ratio index were considerably increased. A full-scale study was carried out in which the nanomaterial product was applied to two different sections of stabilized road compared to a control section. The results obtained showed that the use of nanomaterial led to the possibility of reducing the control section by 30 cm, thus achieving less use of quicklime and a mechanical means for preparing the road section. The use of commercial nanomaterial improved the behavior of the stabilized sub-base layer. Through life cycle assessment, this study has shown that the use of nanomaterials reduces the environmental impact associated with soil stabilization.
Low Velocity Impact Response and Tensile Strength of Epoxy Composites with Different Reinforcing Materials
Authors: Sławski Sebastian , Szymiczek Małgorzata , Kaczmarczyk Jarosław , Domin Jarosław , Świtoński Eugeniusz
Published: July 2020

This paper presents the results of research concerning multilayered epoxy composites reinforced with different materials. The strength of multilayered composites depends, to a large extent, on the reinforcing material. The authors decided to compare the low velocity impact response and perform tensile strength tests on several composites, to ascertain the mechanical properties of the prepared composites. Five different reinforcing materials were provided for the research (two fabrics made from aramid fibers, two fabrics made from carbon fibers and one fabric made from polyethylene fibers). The composites were manufactured by the vacuum supported hand laminating method. The low velocity impact response tests were conducted with the use of a pneumatic launcher. Three strikers with different geometry (conical striker, hemispherical striker and ogival striker) were used. A comparison of the resulting damage to the composites after the impact of the strikers was based on the images obtained using an optical microscope; tensile tests were also performed. The experimental investigation showed significant differences in the mechanical properties of the composites, depending on the applied reinforcing material. It was found that, as a result of the impacts, less damage occurred in the composites which were characterized by a lower Young’s modulus and a higher tensile strength.
Impact of Substituting Coke with Biomass on the Mineralogical Composition of the Iron Ore Agglomerate
Authors: Fröhlichová Mária , Findorák Róbert , Legemza Jaroslav , Džupková Martina
Published: July 2020

Coke breeze is a special type of fossil fuel that significantly contributes to environmental pollution. Therefore, ways and opportunities to reduce its negative impact on climate change are being sought. Alternative fuels constitute one of the opportunities where biomass can play an important role. Biomass represents a new fuel for the sintering process and an attractive way to decrease CO2 emissions. Today, biomass is not considered for complete substitution of coke. Opportunities for its partial substitution are instead being sought. Each type of fuel is characterized by different properties and thus also by an appropriate scope of its substitution in an agglomeration mixture. This study covers the available options and the potential impact of this substitution on the structural and mineralogical composition of the agglomerate. These experiments were carried out by substituting coke breeze with biomass (hydrolyzed lignin). To perform the experimental sintering, a sintering apparatus—laboratory sintering pan (LSP)—was used, which was fully equipped with measuring devices and analyzers. The samples of agglomerates prepared by substituting 0%, 20%, 50% and 86% of coke breeze with biomass (hydrolyzed lignin) in dried form were analyzed by chemical and microscopic analysis-The representation of individual minerals in agglomerates was determined by powder X-ray diffraction analysis. Based on the results of the study regarding the impact of partial coke substitution with biomass on the mineralogical composition of the agglomerate, it can be stated that it is possible to substitute about 50% of coke with lignin in the sintering process. When lignin was used to substitute up to 50% of coke, agglomerates with minimal variations in the chemical and mineralogical composition were produced.
Recent Developments of PFAS-Detecting Sensors and Future Direction: A Review
Authors: Rodriguez Kelsey L. , Hwang Jae-Hoon , Esfahani Amirsalar R. , Sadmani A H M Anwar , Lee Woo Hyoung
Published: July 2020

Per- and poly-fluoroalkyl substances (PFASs) have recently been labeled as toxic constituents that exist in many aqueous environments. However, traditional methods used to determine the level of PFASs are often not appropriate for continuous environmental monitoring and management. Based on the current state of research, PFAS-detecting sensors have surfaced as a promising method of determination. These sensors are an innovative solution with characteristics that allow for in situ, low-cost, and easy-to-use capabilities. This paper presents a comprehensive review of the recent developments in PFAS-detecting sensors, and why the literature on determination methods has shifted in this direction compared to the traditional methods used. PFAS-detecting sensors discussed herein are primarily categorized in terms of the detection mechanism used. The topics covered also include the current limitations, as well as insight on the future direction of PFAS analyses. This paper is expected to be useful for the smart sensing technology development of PFAS detection methods and the associated environmental management best practices in smart cities of the future.
Exploring the Diets of Adults with Obesity and Type II Diabetes from Nine Diverse Countries: Dietary Intakes, Patterns, and Quality
Authors: Willey Jade , Wakefield Marian , Silver Heidi J.
Published: July 2020

Background: Calorie-dense diet is a main driver of the global epidemics of obesity and type 2 diabetes (T2DM). While various dietary strategies and patterns are efficacious in reducing risk and improving glycemic control, dietary intake and diet quality have been inadequately studied among individuals who remain living in their native environments. There is also little published on dietary patterns of diverse ethnic, cultural, or regional populations. Objective: To explore dietary intakes, patterns and overall diet quality in adults with obesity and T2DM from diverse countries. We hypothesized that individuals sharing a common clinical phenotype (age, BMI, years since T2DM diagnosis and inadequate glycemic control) would demonstrate comparable high calorie “western” dietary patterns and low diet quality despite differences in geographic regions and cultures. Design: Diet data were acquired from 611 adults in Argentina, Germany, Poland, Serbia, Slovakia, Slovenia, Spain, Turkey and the USA via three 24-h diet recalls. Contribution of 168 foods to 14 primary food groups was confirmed by Spearman’s rank-order correlations and Principle Component Factor Analysis identified dietary patterns. Diet quality was assessed using the Healthy Eating Index 2015. Results: Eleven dietary patterns were extracted; the most common were a “Mediterranean-like” pattern shared by six countries and a “Calorie Dense” pattern shared by five countries. Also common were “Lacto-Vegetarian, “Pesco-Vegetarian,” and “Vegan” patterns. Only 2.1% of subjects had good diet quality (HEI-2015 score >80). Conclusions: The diet pattern data suggest that influences of more traditional region-specific diets remain. However, overall diet quality was poor and may contribute to inadequate glycemic control, possibly due to excess intake of high calorie/nutrient poor foods, which may be associated with global transitions occurring in the available food supply.
The Effects of Prebiotic Supplementation with OMNi-LOGiC® FIBRE on Fecal Microbiome, Fecal Volatile Organic Compounds, and Gut Permeability in Murine Neuroblastoma-Induced Tumor-Associated Cachexia
Authors: Obermüller Beate , Singer Georg , Kienesberger Bernhard , Klymiuk Ingeborg , Sperl Daniela , Stadlbauer Vanessa , Horvath Angela , Miekisch Wolfram , Gierschner Peter , Grabherr Reingard , Gruber Hans-Jürgen , Semeraro Maria D. , Till Holger , Castellani Christoph
Published: July 2020

Malignant diseases can cause tumor-associated cachexia (TAC). Supplementation with prebiotic non-digestible carbohydrates exerts positive metabolic effects in experimental oncologic diseases. The aim of this project was to assess the effect of prebiotic supplementation with OMNi-LOGiC® FIBRE on intestinal microbiome, bacterial metabolism, gut permeability, and inflammation in a murine model of neuroblastoma (NB)-associated TAC. For this study, 2,000,000 NB cells (MHH-NB11) were implanted into athymic mice followed by daily supplementation with water or 200 mg prebiotic oligosaccharide (POS) OMNi-LOGiC® FIBRE (NB-Aqua, n = 12; NB-POS, n = 12). Three animals of each tumor group did not develop NB. The median time of tumor growth (first visibility to euthanasia) was 37 days (IQR 12.5 days) in the NB-Aqua group and 37 days (IQR 36.5 days) in the NB-POS group (p = 0.791). At euthanasia, fecal microbiome and volatile organic compounds (VOCs), gut permeability (fluorescein isothiocyanate-dextran (FITC-dextran), and gut barrier markers were measured. Values were compared to sham animals following injection of culture medium and gavage of either water or OMNi-LOGiC® FIBRE (SH-Aqua, n = 10; SH-POS, n = 10). Alpha diversity did not differ significantly between the groups. Principal coordinate analysis (PCoA) revealed clustering differences between Aqua and POS animals. Both NB and POS supplementation led to taxonomic alterations of the fecal microbiome. Of 49 VOCs, 22 showed significant differences between the groups. NB animals had significantly higher gut permeability than Aqua animals; POS did not ameliorate these changes. The pore and leak pathways of tight junctions did not differ between groups. In conclusion, our results suggest that NB-induced TAC causes increased gut permeability coupled with compositional changes in the fecal microbiome and VOC profile. Prebiotic supplementation with OMNi-LOGiC® FIBRE seemed to induce modifications of the fecal microbiome and VOC profile but did not improve gut permeability.
D-Pinitol from Ceratonia siliqua Is an Orally Active Natural Inositol That Reduces Pancreas Insulin Secretion and Increases Circulating Ghrelin Levels in Wistar Rats
Authors: Navarro Juan A. , Decara Juan , Medina-Vera Dina , Tovar Rubén , Suarez Juan , Pavón Javier , Serrano Antonia , Vida Margarita , Gutierrez-Adan Alfonso , Sanjuan Carlos , Baixeras Elena , Fonseca Fernando Rodríguez de
Published: July 2020

To characterize the metabolic actions of D-Pinitol, a dietary inositol, in male Wistar rats, we analyzed its oral pharmacokinetics and its effects on (a) the secretion of hormones regulating metabolism (insulin, glucagon, IGF-1, ghrelin, leptin and adiponectin), (b) insulin signaling in the liver and (c) the expression of glycolytic and neoglucogenesis enzymes. Oral D-Pinitol administration (100 or 500 mg/Kg) resulted in its rapid absorption and distribution to plasma and liver compartments. Its administration reduced insulinemia and HOMA-IR, while maintaining glycaemia thanks to increased glucagon activity. In the liver, D-Pinitol reduced the key glycolytic enzyme pyruvate kinase and decreased the phosphorylation of the enzymes AKT and GSK-3. These observations were associated with an increase in ghrelin concentrations, a known inhibitor of insulin secretion. The profile of D-Pinitol suggests its potential use as a pancreatic protector decreasing insulin secretion through ghrelin upregulation, while sustaining glycaemia through the liver-based mechanisms of glycolysis control.
The Relationship between Protein Intake and Source on Factors Associated with Glycemic Control in Individuals with Prediabetes and Type 2 Diabetes
Authors: Akhavan Neda S. , Pourafshar Shirin , Johnson Sarah A. , Foley Elizabeth M. , George Kelli S. , Munoz Joseph , Siebert Shalom , Clark Elizabeth A. , Basiri Raedeh , Hickner Robert C. , Navaei Negin , Levenson Cathy W. , Panton Lynn B. , Daggy Bruce P. , Arjmandi Bahram H.
Published: July 2020

Type 2 diabetes (T2D) is a major contributor to morbidity and mortality largely due to increased cardiovascular disease risk. This study examined the relationships among protein consumption and sources on glycemic control and cardiovascular health in individuals with prediabetes and T2D. Sixty-two overweight or obese participants with prediabetes or T2D, aged 45–75 years were stratified into the following three groups based on protein intake: <0.8 g (gram)/kg (kilogram) body weight (bw), ≥0.8 but <1.0 g/kg bw, and ≥1.0 g/kg bw as below, meeting, and above the recommended levels of protein intake, respectively. Body mass, body mass index (BMI), hip circumference (HC), waist circumference (WC), lean mass, and fat mass (FM) were significantly higher in participants who consumed below the recommended level of protein intake as compared with other groups. Higher animal protein intake was associated with greater insulin secretion and lower triglycerides (TG). Total, low-density, and high-density cholesterol were significantly higher in participants who met the recommended protein intake as compared with the other groups. These data suggest that high protein consumption is associated with lower BMI, HC, WC, and FM, and can improve insulin resistance without affecting lipid profiles in this population. Furthermore, higher intake of animal protein can improve β-cell function and lower plasma TG.
MODELING OF THE SYSTEM OF MANAGEMENT OF EDUCATIONAL PROCESS AS A BASIS FOR IMPROVING THE QUALITY OF MATHEMATICAL AND NATURAL EDUCATION IN SECONDARY EDUCATION INSTITUTIONS
Authors: Kyrychkov Yuriy
Published: July 2020

The author researches the management of educational processes. Author's developments on management of these processes are presented, as well as the model of “Conflict-free education” which give positive results in practice.
KETIADAAN ANAK LAKI-LAKI: AKANKAH MENJADI FAKTOR PENGHALANG PEMAKAIAN KONTRASEPSI?
Authors: Trisnani Dwi
Published: July 2020

Tingkat penggunaan alat kontrasepsi (CPR) dan fertilitas (TFR) yang berbeda antar provinsi menimbulkan pertanyaan apakah ada pengaruh budaya terhadap  pemakaian alat kontrasepsi modern yang merupakan program pemerintah melalui BKKBN. Perbedaaan TFR dan CPR antara Provinsi Sumatera Utara yang memperlihatkan masih tingginya TFR dan rendahnya CPR dibandingkan dengan Jawa Tengah menimbulkan dugaan bahwa hal ini terjadi karena adanya budaya yaitu sistem kekerabatan patrilineal pada Suku Batak yang merupakan suku yang dominan di Sumatera Utara. Budaya patrilineal yang memberi nilai lebih anak laki-laki menyebabkan berkurangnya keikutsertaan wanita dalam menggunakan alat kontrasepsi karena adanya keinginan untuk memiliki anak laki-laki. Penelitian ini bertujuan untuk mengetahui pengaruh komposisi jenis kelamin anak masih hidup yang dimiliki wanita terhadap penggunaan alat KB modern di Provinsi Sumatera Utara dan Jawa Tengah. Data yang digunakan adalah data dari Survei Demografi dan Kesehatan Indonesia (SDKI). Dalam studi ini, data yang digunakan adalah data cross-sectional untuk survei tahun 2017 di wilayah Sumatera Utara dan Jawa Tengah. Hasil analisis menunjukkan bahwa di Sumatera Utara wanita yang mempunyai anak laki-laki saja berpeluang lebih besar untuk memakai alat kotrasepsi modern daripada wanita yang tidak mempunyai anak laki-laki yang menunjukkan masih adanya son preference, sedangkan di Jawa Tengah komposisi jenis kelamin mempengaruhi penggunaan alat kontrasepsi.

 

Differences in levels of contraceptive use (CPR) and fertility (TFR) between provinces raise the question of whether there is a cultural influence on the use of modern contraception which is a government program through the BKKBN. The difference of TFR and CPR between North Sumatra Province which shows high TFR and low CPR compared to Central Java raises suspicion this is caused by patrilineal kinship culture in the Batak tribe which is the dominant tribe in North Sumatra. A patrilineal culture that gives more value to boy/s leads to reduced participation of women in using contraception because of the desire to have a son. This study aims to determine the effect of children sex composition on the use of modern family planning in North Sumatra and Central Java Province. The data used are data from the Indonesian Demographic and Health Survey (IDHS). In this study, the data used were cross-sectional data for the 2017 survey in North Sumatra and Central Java. In North Sumatra, the analysis showed that women who only had boys had a greater chance of using modern contraception than women who did not have boys who showed preference for boys, whereas in Central Java the sex composition does not affect contraceptive use.
KORELASI KELUHAN KESEHATAN IBU DAN ANGKATAN KERJA PEREMPUAN TERHADAP PEROKOK ANAK
Authors: Mayasari Shaela
Published: July 2020

Persentase jumlah perokok anak (?18 tahun) terus mengalami kenaikan tiap tahunnya. Merokok di usia sangat muda tentu berpengaruh pada kesehatan anak. Tidak hanya sekarang, tapi di masa depan. Untuk itu, diharapkan peran orang tua bisa membuat anak menjauhi aktifitas merokok. Maka penting untuk mengetahui kualitas kesehatan ibu dan ketersediaan waktu luangnya dalam mendidik anak. Penelitian ini bertujuan untuk menggambarkan pengaruh keluhan kesehatan yang dialami ibu dan pengaruh ibu bekerja yang masuk sebagai angkatan kerja perempuan terhadap perokok anak.  Jenis penelitian ini kuantitatif.  Dengan metode analisis uji korelasi sederhana dan statistik deskriptif. Adapun sumber datanya ialah data sekunder BPS tahun 2016-2018.  Hasil dari penelitian ini menyatakan hubungan antara keluhan kesehatan yang dialami ibu berkorelasi kuat dengan perokok anak, dimana nilai R2 =0.9663. Hubungan antara perokok anak dengan jumlah angkatan kerja perempuan, juga menunjukkan korelasi positif yang kuat dimana nilai R2 nya 0.9289. Karena keterbatasan data dan waktu, penelitian ini hanya bisa menggambarkan perkembangan pekerja anak, perkembangan keluhan kesehatan ibu, dan perkembangan angkatan kerja perempuan. Selanjutnya diperlukan penelitian lebih komperehensif lagi terhadap hubungan ketiganya.

 

The percentage of child smokers (?18 years) continues to increase every year. Smoking at a very young age certainly affects the health of children. Not only now, but in the future. For this reason, it is hoped that the role of parents can make children stay away from smoking. So it is important to know the quality of maternal health and the availability of free time in educating children. This study aims to describe the effect of health complaints experienced by mothers and the influence of working mothers who enter the female workforce on child smokers. This type of research is quantitative. With the simple correlation test analysis method and descriptive statistics. The source of the data is BPS secondary data for 2016-2018. The results of this study stated the relationship between health complaints experienced by mothers strongly correlated with child smokers, where the value of R2 = 0.9663. The relationship between child smokers and the number of female workforce, also shows a strong positive correlation where the R2 value is 0.9289. Because of limited data and time, this study can only describe the development of child labor, the development of maternal health complaints, and the development of the female workforce. Furthermore, more comprehensive research is needed on the relationship of the three.
Perancangan Ajri Learning Journal Center Menggunakan Tools Invision Untuk Mewujudkan Creative Innovation Soft Skill
Authors: Hariguna Taqwa , Wahyuningsih Tri
Published: July 2020

Platform penyedia layanan pelatihan dan materi penulisan karya ilmiah secara online untuk memotivasi  civitas akademik untuk melakukan penelitian. Dengan memanfaatkan metode pengembangan sistem yaitu waterfall dalam menganalisis agar platform yang dikembangkan berjalan sesuai dengan apa yang direncanakan. Pada saat ini sangat jarang penyedia layanan dalam pelatihan penulisan yang dilakukan secara online. Biasanya dilakukan conference yang mengharuskan seseorang hadir dalam ruangan dan mendengarkan pembicara berjam-jam. Maka pelatihan secara online dianggap sangat efektif untuk mendorong civitas akademik dalam membuat karya ilmiah karena dapat dilakukan dimanapun dan kapanpun. Dengan diimplementasikannya platform ini akan ada 2 manfaat yaitu (1) Termotivasinya civitas akademik untuk melakukan penelitian, karena ada banyak kemudahan untuk berlatih dalam penulisan yang dapat dilakukan dimanapun dan kapanpun. (2) Jumlah penelitian di Indonesia akan meningkat dalam rangka mendukung program Tridharma Perguruan Tinggi. Penelitian ini akan diimplementasikan pada sebuah website yang mampu diakses secara online, yang berisi pelatihan penulisan secara online berupa video pembelajaran dengan beberapa coach yang profesional. Disediakan pula materi pembelajaran bagaimana cara menulis sebuah karya ilmiah sesuai dengan standar yang benar.
Comparison of CAS and Manage Oauth in Single Sign on (SSO) Client Applications
Authors: Watini Sri , Nursaputri Pipit , Iqbal Muhammad
Published: July 2020

Single Sign On is one of the systems that have been developed long ago to meet the expectations of developers to provide ease and convenience of accessing data. In the development of the system, methods and protocols have been formed in varied ways to suit the needs of the developers . In a variety of methods and protocols , a developer can choose the architecture and protocols that can be used to develop the system. Central Authentication Service and Open authorization is two Single Sign On systems most widely used in the manufacture of a web log . Both can be used as the basis for the application of the system of Single Sign On for developers who intend to design a login system that is safe and comfortable , so that developers can create a system that suits his desire .
Implementation of Student Performance Management Guidance to Improve Quality Study at Colleges
Authors: Dolan Ellen , Bein Adrian Sean
Published: July 2020

Student attendance activities can take place well and smoothly With a very active student to attend each attendance Student guidance in completing the research. With it, it takes Attentive attention to the student's attendance. Known systems that have an important role for student guidance are the Attendance assessment system and the higher education service system that is absolutely necessary for lecturers Supervisor for monitoring research at higher education. One of the media information is a very important Viewboard in the The Pen System (attendance Assessment) on the Viewboard Pen used for Assessment of attendance of students to get complete data and accuracy. However, existing Viewboard Pens do not currently have a Viewboard Performance that can be a benchmark in comparing Student attendance. There are 3 (three) issues that cause Alternative problems include the absence of information to display Reanytime Student attendance for a certain period of time. Furthermore, the absence of Performance graphs that can measure the performance of student attendance, And the absence of search filters for a certain period of time. Therefore, Designed a Viewboard using the Bootstrap template and also Using the SWOT method. Using 4 (four) methods System analysis using user requirement, design method Using Prototype, HIPO, Flowchart and UML (Unified Modelling Language). The Viewboard Pen is designed using Yii Framework and hopefully helpful in solving problems Attendance at the previous system and motivating students Guidance to be more active.
Design and Physical Modelling Series Elastic Actuator for Ankle-Foot Orthosis
Authors:   Manufacturing Section, Universiti Kuala Lumpur Malaysian Spanish Institute, Kulim HiTech Park, Kulim, Kedah, Malaysia., Abdullah Aznizam , Mazelan Marzuki Azwani bin ,   Student, Bechelor of Engineering (Hons) Mechatronics (Automotive), Universiti Kuala Lumpur Malaysian Spanish Institute, Kulim HiTech Park, Kulim, Kedah, Malaysia, Ahmad Fathul Hazrimy ,   Electrical Electronic and Automation Section, Universiti Kuala Lumpur Malaysian Spanish Institute, Kulim HiTech Park, Kulim, Kedah, Malaysia., Krishnan Pranesh ,   Electrical Electronic and Automation Section, Universiti Kuala Lumpur Malaysian Spanish Institute, Kulim HiTech Park, Kulim, Kedah, Malaysia, Yaacob Sazali ,   Intelligent Automotive Systems Research Cluster, Electrical Electronic and Automation Section, Universiti Kuala Lumpur Malaysian Spanish Institute, Kulim HiTech Park, Kulim, Kedah, Malaysia.
Published: July 2020

This paper describes the development of Physical Modelling of Series Elastic Actuator for Active Ankle-Foot Orthosis by using Simscape Multibody Link. Active Ankle-Foot Orthosis is essential that can be used for the rehabilitation process to the patient. It is useful in medicine to help a patient who loses their walking ability, due to ankle weakness, to regain the walking ability. This project focuses on the design, simulate and physical modelling for Ankle-Foot Orthosis. This project was used Solidworks as a platform to design the Active Ankle-Foot Orthosis and using MatLab/Simulink for simulation by using Simscape Multibody Link tools. The Active Ankle-Foot Orthosis moves in 2 basic movement of ankle that is dorsiflexion and plantar flexion for rehabilitation. So, this project focuses on the physical modelling for the Series Elastic Actuator that drives the ankle movement mimicking the normal gait cycle.