bluuebunny/crossref_metadata_2025 huggingface dataset:
GRAVIDEZ ECTÓPICA SEGMENTAR COM 21 SEMANAS DE IDADE GESTACIONAL: UM RELATO DE CASO
Authors: Faria Ulhoa Ana , Ferreira Resende Márcia , Rita de Souza Bertoloni Camila , De Neiva Granja Felippe
Published: November 2021

Gestação fora da cavidade corporal do útero é denominada gravidez ectópica, sendo esta a principal causa de morte materna no primeiro trimestre. Quando se desenvolvem na intimidade do miométrio de uma cicatriz de cesariana prévia, denomina-se gravidez em cicatriz de cesárea. O objetivo deste relato foi descrever um caso de gestante com 21 semanas apresentando gravidez ectópica segmentar na cicatriz uterina de cesárea prévia, na qual devido riscos em manter a gestação, bem como a inviabilidade da mesma, optado por interrupção da gestação. A implantação e o desenvolvimento da gestação na cicatriz de cesárea prévia é uma forma rara de gravidez ectópica com potencial risco de vida. O diagnóstico precoce e o tratamento adequado, podem prevenir as complicações. O tratamento deve ser individualizado pois depende de diversos fatores e varia em conduta expectante, medicamentosa e cirúrgica. Ainda é difícil indicar em qual caso terá um bom prognóstico. Portanto, o procedimento cirúrgico, tão logo seja firmado o diagnóstico, é a melhor forma de evitar as temíveis complicações.
INFLUÊNCIA DO ISOLAMENTO OBRIGATÓRIO NO SERVIÇO DE CIRURGIA E TRAUMATOLOGIA BUCOMAXILOFACIAL EM UM HOSPITAL DE TRAUMA NÍVEL 1 DURANTE A PANDEMIA DO NOVO CORONAVÍRUS 2019 (COVID-19).
Authors: Braga Laura Braga Figueiredo , Figueiredo Amaral Marcio Bruno , Soares Araújo Stella Cristina , Lanes Silveira Roger
Published: November 2021

INTRODUÇÃO: A pandemia do Novo Coronavírus 2019, afetou diversos países, devido à alta virulência do SARS-Cov-2, o protocolo recomendado para prevenir a infecção é o isolamento social.

OBJETIVO: Comparar o número de pacientes internados e seus dados epidemiológicos em um Hospital do Trauma após a declaração do estado de pandemia e na primeira semana de isolamento obrigatório, com o mesmo período em 2019.

METODOLOGIA: Estudo retrospectivo dos prontuários dos pacientes internados no Serviço de Cirurgia Bucomaxilofacial do Hospital João XXIII, entre 24 de março a 31 de março de 2020 e 2019. A coleta de dados contemplou um total de 129 prontuários.

RESULTADOS: Houve redução de 52,27% no total de pacientes e 76,34% no total de consultas do serviço durante o bloqueio. Todos os grupos apresentaram diminuição da significância com eventos de acidentes de trânsito, o grupo de 11-20 anos apresentou aumento na correlação com violência e quedas. Ao comparar os dois gêneros com as etiologias, o masculino apresentou aumento na correlação com violência e quedas. O gênero feminino apresentou correlação apenas com causas menores. Nenhuma significância válida foi observada ao comparar mulheres com eventos de violência.

 

 

CONCLUSÃO: O lockdown é uma forma eficaz de reduzir não só a transmissão do COVID-19, mas o uso e ocupação hospitalar, o que traz um duplo benefício ao sistema de saúde no momento da pandemia.
POBREZA MENSTRUAL: UMA QUESTÃO DE SAÚDE PÚBLICA
Authors: Marques Heck de Piau Vieira Lorena , Pereira Lopes Luíza , Gabriela Ferreira Carvalho Maria
Published: November 2021

INTRODUÇÃO: Pobreza ou precariedade menstrual é um conceito que engloba o desafio vivenciado por bilhões de pessoas, no Brasil e no mundo, que não tem acesso adequado à saneamento básico, itens de higiene pessoal, protetores menstruais ou banheiros. Segundo dados da ONU, 12,5% da população feminina sofrem com este obstáculo, o que pode ser penoso durante a menstruação. Trata-se de um tema que reflete uma problemática sistêmica de desigualdade social e de gênero.

 

OBJETIVOS: Analisar a realidade das mulheres brasileiras que menstruam, a dificuldade de acesso aos seus direitos menstruais e o impacto gerado na vida destas.

METODOLOGIA: Revisão sistemática de artigos científicos originais nas bases de dados do PubMed, Medline, Lilacs e Scielo. Ao enfatizar os termos “Mulher”, “Pobreza”, “Menstruação”, foram selecionados “10” artigos, dos anos 1997 a 2021, relacionados ao assunto abordado. Utilizou-se como critério de escolha: pesquisas científicas até o ano de 2021 escritas e publicadas em português e inglês, selecionando aquelas que abordaram dados epidemiológicos, definições e políticas públicas sobre a pobreza menstrual.

 

RESULTADOS: No Brasil aproximadamente 26% das mulheres sofrem o impacto da pobreza menstrual.  A falta de acesso a absorventes, por exemplo, leva ao uso inapropriado de papéis, sacolas plásticas, meias e jornais, com consequente surgimento de vulvovaginites, infecções do trato urinário e outras complicações. A situação se agrava para presidiárias, refugiadas e moradoras de rua. Ademais, além de afetar a saúde física e psíquica de inúmeras pessoas, faz perdurar a desigualdade entre homens e mulheres. 10% das meninas não comparecem às aulas quando estão menstruadas. Neste mesmo contexto, sabe-se que o nosso país possui uma das mais elevadas taxações sobre absorventes no mundo, com tributação média de 25% do produto. Isto, somado à não distribuição de tais produtos e o descaso na criticidade da situação demonstram a importante de se debater a respeito.

 

CONCLUSÃO: Com base na análise feita, é imprescindível dizer que a pobreza menstrual impacta negativamente na vida de milhares de mulheres no Brasil. Assim, este atual cenário evidencia a necessidade de mais políticas públicas de saúde para zelar pela dignidade humana da população feminina que sofre diariamente com a escassez de condições adequadas para o período menstrual.
ANÁLISE DO DIMENSIONAMENTO DE PROFISSIONAIS DE ENFERMAGEM EM UMA UNIDADE DE INTERNAÇÃO PEDIÁTRICA
Authors: Rigo Felipe Leonardo , De Matos Costa Relbson , Iracy Alves Leite Elizabeth , Henriques Gomes Miranda Carolina
Published: November 2021

INTRODUÇÃO: As hospitalizações pediátricas são experiências complexas que se apresentam como um desafio para implantar modelos de assistência de enfermagem com foco na atenção ao paciente e sua família. A qualidade da assistência de enfermagem aos pacientes hospitalizados está diretamente relacionada aos aspectos quantitativos e qualitativos dos recursos humanos, isto é, ao dimensionamento de pessoal de enfermagem (DPE). OBJETIVO: Caracterizar o perfil dos pacientes hospitalizados em uma unidade de internação pediátrica em categorias de cuidado, determinar o Dimensionamento de Pessoal de Enfermagem adequado a este perfil e compará-lo à atual oferta de profissionais de enfermagem deste serviço. METODOLOGIA: Estudo descritivo, de caráter quantitativo, realizado na Unidade de Internação Pediátrica (UIP) de um hospital infantil público localizado em Belo Horizonte. A amostra do estudo foi composta por todos os pacientes hospitalizados na UIP. Os dados foram coletados de forma prospectiva, no período 05 de janeiro a 05 de fevereiro de 2019.  Para classificação dos pacientes em categorias de cuidados de enfermagem, foi aplicada a versão beta do ICPP(9), instrumento sugerido pela Resolução COFEN 0543/2017. Estudo aprovado pelo Parecer nº 4.197.135. RESULTADOS: Foram obtidos um total de 2501 classificações através do Instrumento de Classificação de Pacientes Pediátricos versão beta proposto por Dini e Guirardello. A maioria das classificações foi do sexo masculino (53,97) e a faixa etária de maior frequência foi Lactentes (45,92%), seguida de Pré-escolares (20,60%). As pontuações das classificações variaram entre 12 e 40 com mediana de 29 (IQ 27 - 31). A maioria dos pacientes hospitalizados foi classificada como PCAD (55,46%), seguido de PCSI (31,55%). Identificou-se um déficit de 67,6% para enfermeiros e um excedente de 15,34% para auxiliares/técnicos de enfermagem. CONCLUSÃO: Os achados desta pesquisa foram coerentes com outros estudos. A adequação do dimensionamento da equipe de enfermagem pode reduzir a sobrecarga de trabalho, o acúmulo de tarefas e o conflito nos papéis vivenciados pelos enfermeiros. Esta adequação pode ainda favorecer a implantação do PE e da SAE, favorecendo a melhora da qualidade assistencial a redução do risco de eventos adversos relacionados à assistência em saúde.

Palavras-chave: Enfermagem; Dimensionamento de Pessoal; Pediatria
Do avanço ao recuo
Authors: Nanci Izidro Gonçalves Fernanda Cristina , Oliveira dos Santos Nathan
Published: November 2021

Este artigo analisa a política externa estadunidense para Cuba durante os governos Barack Obama (2009–2017) e Donald Trump (2017–2020), buscando responder à pergunta: quais razões permitem compreender as diferenças na abordagem dos governos Obama e Trump em relação à Cuba? Para tanto, realiza-se um estudo de caso comparado e utiliza-se a abordagem teórica de Helen Milner, que explica quais são os interesses, as instituições e as informações que afetam o processo decisório. Conclui-se que a correlação das diferentes pressões domésticas, somadas aos interesses de reeleição dos presidentes, contribuíram para a formulação das diferentes abordagens dos governos.
Presentación
Authors: Navarro Mariano
Published: November 2021

Me permito dar la bienvenida a los lectores de este núme ro de la Revista Panamericana de Comunicación con mi deseo de que su contenido no solo sea una fuente de información sino, sobre todo, una base de reflexión que contribuya a originar nuevas ideas científicas. Y ello a partir de un tema monográfico que, en este número, se ocupa de algunos de los hitos esenciales en el devenir histórico de los medios de comunicación en México.
Los medios de comunicación en México
Authors: Fernández Fernández Iñigo
Published: November 2021

Vivimos en un mundo que se distingue, entre otros motivos, por el predominio de los medios masivos de comunicación. Asumimos que éstos, en sus distintas manifestaciones y plataformas, son auténticas ventanas que nos liberan de los grilletes del tiempo y del espacio para ser testigos en tiempo real de lo que acontece en nuestro entorno y en el mundo.
La presencia del colofón en la historia del libro en México
Authors: Fernández de Zamora Rosa María
Published: November 2021

El colofón tiene una larga presencia en la historia del libro en México y, en el mundo, ha jugado un importante papel ya que ha proporcionado una información relevante para el conocimiento de las obras. Al llegar los incunables, el colofón poco a poco fue perdiendo importancia porque la portada daba la información necesaria, pero muchos incunables no tenían portada, entonces el colofón proporcionaba la información sobre el autor, el impresor, el lugar y la fecha de impresión y así continuó su presencia en los siglos siguientes hasta el presente. El artículo expone la evolución de las características del colofón en México basándose en una amplia selección de ilustraciones.
La cobertura informativa al Tercer Centenario de El Ingenioso Hidalgo Don Quijote de la Mancha en la prensa mexicana (1903-1905)
Authors: Vázquez Clavellina Iván Baruj
Published: November 2021

En mayo de 1905 se celebraron tres siglos de la publicación de la primera edición de El Ingenioso Hidalgo Don Quijote de la Mancha. La propuesta de celebrar el tercer centenario fue promovida inicialmente en la prensa por periodistas e intelectuales en España y posteriormente en México. El siguiente artículo analiza la cobertura informativa al tercer aniversario de la obra en la prensa mexicana. El objetivo fue identificar festejos, ceremonias y concursos a través de notas publicadas en periódicos, semanarios y revistas. Para obtener la información se utilizó el acervo de la Hemeroteca Digital Nacional de México (HNDM) y se localizaron notas que tratan la organización del homenaje y las fiestas establecidas por eruditos y funcionarios. Los resultados descubren publicaciones, periodistas y corresponsales que reportaron los festejos, y ayudaron a consolidar a Don Quijote como la obra literaria más importante en lengua castellana durante los primeros años del siglo XX.
Un periódico electoral : El 2 de abril (1880)
Authors: Vieyra Sánchez Lilia
Published: November 2021

El artículo analiza el periódico El 2 de Abril publicado el año de 1880 para promover como candidato a Carlos Pacheco a la gobernatura de Puebla. El objetivo de esta investigación es demostrar que ese semanario fue erigido como parte de la estrategia electoral que utilizó Porfirio Díaz en la que era fundamental obtener el sufragio a partir de recordar la batalla del 2 de abril de 1867 en la que Pacheco perdió un brazo y una pierna, pero contribuyó a derrotar el gobierno de Maximiliano de Habsburgo. Esa gesta heroica generó un símbolo patriótico que Díaz esgrimió tanto en el caso de Pacheco como en el de Manuel González y durante los procesos electorales en que se reeligió por varios cuatrienios. El aporte de esta investigación frente a los estudios especializados en la prensa electoral, que aquí se incluyen, es que utiliza los periódicos como fuente para documentar la vida de ese semanario sufragista de existencia fugaz del que poco se conoce y brinda datos de su recepción entre los periódicos partidarios de Díaz y los opuestos a su gobierno. Al mismo tiempo, contribuye a explicar los motivos que originaron su resguardo en la Colección de Misceláneas Mexicanas del Fondo Reservado de la Hemeroteca Nacional de México.
Las fuentes documentales de las que se sirvió Madame Calderón de la Barca en su libro La vida en México durante una residencia de dos años en ese país (1839-1841)
Authors: López García Ana Belén
Published: November 2021

En el siglo XIX es fundamental la lectura de los libros de viajes para conocer la identidad nacional de un país. Este artículo pretende analizar las fuentes documentales que utilizó Madame Calderón de la Barca en su obra La vida en México durante una residencia de dos años en ese país (1839-1843). Los principales temas que aparecen descritos en sus páginas están documentados en distintas publicaciones periódicas de la época como El Mosaico Mexicano,El Boletín del Gobierno,El Cosmopolita,Un periódico más,El Censor de Veracruz,El Mosquito Mexicano y la Gaceta del Gobierno, entre otros y en el libro de viajes del historiador alemán Humboldt. Un epistolario que generó muchas contradicciones y ambigüedades sobre la visión que la autora ofrece sobre el país mexicano incluso en el propio uso de las fuentes que lo documentan.
Estampas de la guerra de propaganda entre México y Estados Unidos en 1938
Authors: Sánchez de Armas Miguel Ángel
Published: November 2021

La expropiación de la industria petrolera extranjera en marzo de 1938 fue un momento clave en la vida del México posrevolucionario. Por su carga simbólica propició la cohesión ideológica en el proceso de formación de una nueva identidad nacional anclada en los postulados de la Revolución y de la Constitución de 1917. En lo económico, echó los cimientos del modelo de desarrollo mexicano que persiste al día de hoy. Y en materia de política internacional, una de sus consecuencias fue intensa y prolongada guerra de propaganda entre México, EUA Inglaterra.
La Asimilación de Discursos Mítico-Rituales Mexicas en Tetzapotitlan.
Authors: Márquez Lorenzo Emmanuel
Published: November 2021

La provincia de Tetzapotitlan, sitio arqueológico correspondiente con la actual localidad de Castillo de Teayo, en el Norte de Veracruz, presenta una gran cantidad de monumentos arqueológicos que permiten conocer a profundidad las dinámicas políticas y religiosas públicas de sus poblaciones prehispánicas. Sin embargo, gran cantidad de las esculturas tetzapotecas reflejan parte de la ideología de otras sociedades, especialmente del Altiplano, lo cual ha requerido de una diversidad de estudios (Márquez, 2009, 2012a, 2012b, 2013, 2014, 2015a, 2015b, 2015c, 2017, 2019, 2020, 2021a, 2021b) que han permitido profundizar en el fenómeno complejo atravesado por esta localidad entre los años 1444 y 1521, durante los cuales ocurre una gran cantidad de guerras por parte de la Triple Alianza de México, Texcoco y Tlacopan. Estas acciones militares ocasionaron la sujeción definitiva de Tetzapotitlan en 1480, pero también el despoblamiento, esclavización y matanza de varones nativos de la localidad en México Tenochtitlan en 1487. A partir de este año, los discursos oficiales tetzapotecas se modificaron profundamente, debido a la presencia de una nueva población con un bagaje cultural en apariencia distinto, como se observa en las representaciones escultóricas, pero en esencia similar, de ahí que su culto haya sido asimilado (en honor de la tierra, la lluvia y el maíz). El poder político y religioso expresado propagandísticamente en las celebraciones y festividades orilló a los tetzapotecas a aceptar estos cambios culturales, y eso explica, a su vez, el por qué de la existencia de tales esculturas.
Práticas de manejo e conservação do solo da cultura cafeeira na bacia hidrográfica do Riacho Água Fria, Barra do Choça – Bahia.
Authors: Soares Bruno Souza
Published: November 2021

A Bacia hidrográfica do Riacho Água Fria, está localizada no município de Barra do Choça, possuindo uma área de 125 km². A cafeicultura é uma importante atividade agrícola desenvolvida na bacia. O presente trabalho teve como finalidade, principal, avaliar as práticas de manejo e conservação do solo na cultura cafeeira na bacia. A pesquisa de campo constou do levantamento da eficácia das práticas conservacionistas, através do preenchimento de uma matriz de campo, como também a aplicação de questionários junto aos produtores rurais. O trabalho de gabinete abrangeu os trabalhos teóricos e a sistematização e análise do dados e informações de campo. Como resultados o trabalho aponta que as práticas de manejo e conservação dos solos têm permitido o equilíbrio dos sistemas socioambientais, contribuindo para a manutenção de uma elevada capacidade hídrica da bacia e do Sistema Água Fria de abastecimento urbano. No entanto, vários são os pontos isolados em que foram constatadas diversas situações de conflitos entre o potencial de uso e o uso efetivo dos solos na bacia, podendo contribuir significativamente para uma situação de ameaça do seu potencial ambiental.
PROPOSTA PRELIMINAR DE MAPEAMENTO GEOMORFOLÓGICO DA BACIA DO RIO SERIDÓ RN/PB.
Authors: Rabelo Davi Rodrigues
Published: November 2021

O modo como a sociedade se apropria da natureza e de seus recursos naturais, modificando-a de acordo com seus interesses, faz com que esta mesma sociedade cause alguns impactos ao ambiente que é utilizado. A geomorfologia é um ramo da geografia física e estuda a evolução, descrição e análise do relevo, com isso servindo como base para os diversos planejamentos ambientais. A presente realizou um mapeamento geomorfológico da bacia hidrográfica do Rio Seridó com a finalidade de servir como planejamento ambiental e territorial da área. Foram utilizados produtos e softwares das geotecnologias, assim como revisões bibliográficas acerca do tema deste trabalho. Foram identificadas noves feições geomorfológicas divididas em dois grandes domínios morfoestruturais, com isso, analisadas e descrita essas feições. Portanto, o mapeamento geomorfológico auxilia no processo de análise territorial e ambiental dos municípios envolvidos em uma bacia hidrográfica.
The Prepropalustrin-2CE2 and Preprobrevinin-2CE3 Gene from Rana
chensinensis: Gene Expression, Genomic Organization and Functional
Analysis of the Promoter Activity
Authors: Zhang Ruifen , Gao Jing , Xie Hui , Sun Yan , Zhang Yuan , Song Jing , Xiang Nanshu , Li Zhi
Published: November 2021

Background:

For amphibians, antimicrobial peptides are innate immune molecules that
resist adverse external environmental stimuli. However, the regulation mechanism of antimicrobial
peptide gene expression in frogs is still unclear.

Objective:

The two antimicrobial peptides, palustrin-2CE2 and brevinin-2CE3, are produced under
external stimulation in Rana chensinensis. Using this model, we analyzed the gene structure and
regulatory elements of the two antimicrobial peptide genes and explored the regulatory effects of related
transcription factors on the two genes.

Method:

Different stimuli such as E. coli, S. aureus, and chemical substance lipopolysaccharide
(LPS) were applied to Rana chensinensis tadpoles at different developmental stages, and antimicrobial
peptide expression levels were detected by RT-PCR. Bioinformatics analysis and 5'-RACE
and genome walking technologies were employed to analyze the genome structure and promoter region
of the antimicrobial peptide genes. With dual-luciferase reporter gene assays, yeast one-hybrid
experiment and EMSA assays, we assessed the regulatory effect of the endogenous regulators
of the cell on the antimicrobial peptide promoter.

Results:

The transcription levels of prepropalustrin-2CE2 and preprobrevinin-2CE3 were significantly
upregulated after different stimulations. Genomic structure analysis showed that both genes
contained three exons and two introns. Promoter analysis indicated that there are binding sites for
regulatory factors of the NF-κB family in the promoter region, and experiments showed that endogenous
NF-κB family regulatory factors in frog cells activate the promoters of the antimicrobial
peptide genes. Yeast one-hybrid experiment and EMSA assay demonstrated that RelA and NF-κB1
might interact with specific motifs in the prepropalustrin-2CE2 promoter.

Conclusion:

In this paper, we found that the gene expression levels of the antimicrobial peptides,
palustrin-2CE2 and brevinin-2CE3, in R. chensinensis will increase under environmental stimuli,
and we verified that the changes in gene expression levels are affected by the transcription factors
RelA and NF-κB1. The yeast one-hybrid experiment and EMSA assay confirmed that RelA and
NF-κB1 could directly interact with the frog antimicrobial peptide gene promoter, providing new
data for the regulatory mechanism of antimicrobial peptides in response to environmental stimuli.
Effects of Co-Solvents on Loading and Release Properties of Self-
Assembled Di-Peptide Building Blocks, Towards Drug Delivery
Applications
Authors: Yazdani Sara , Ghoreishi Seyed Mohammad , Habibi Neda
Published: November 2021

Background:

Due to their solid-like porous structure, molecular organogel and microcrystal
structures have the capabilities of loading drug molecules, encapsulation, and extended release,
all considered as essential properties in drug delivery applications. Phases of these structures,
however, depend on the solvent used during the gelation process.

Objective:

Understanding the phase transition between organogel and microcrystal structures
through adjusting the mixture ratio of different co-solvents.

Method:

Short peptide Diphenylalanine as the gelation building block was used due to its amino
acid sequences that can be exactly selected at its molecular levels. Ethanol as a polar solvent was
used in combination with four other co-solvents with different polarity levels, namely Xylene,
Toluene, Acetone, and Dimethyl Sulfoxide. The morphology of molecular structures of each co-solvent
combination at each ratio level was examined as well as the loading and release properties for
a non-polar Flufenamic Acid drug.

Results:

The resultant structure wasaffected by the polarity of the co-solvents; in particular, in the
sample containing 25 μg/ml of the drug, 94% of the drug amount was loaded inside the organogel.
By increasing the drug concentration to 50, 75, and 100 μg/ml, the loading capability decreased to
76%, 47%, and 33%, respectively.

Conclusion:

Molecular organogels have excellent capabilities of loading drug molecules, while microcrystal
structures have higher release capacity. The findings of this study reveal how to best design
a gelation method to obtain maximum loading or release properties for a particular peptide-
based drug delivery application.
D-amino Acids as Novel Blood-based Biomarkers
Authors: Murtas Giulia , Pollegioni Loredano
Published: November 2021

Background:

D-amino acids are present in the human body originating from
diet, bacterial flora, and endogenous synthesis (at least for D-serine and, probably, D-aspartate).
D-amino acids are involved in important physiological processes (e.g., D-serine
and D-aspartate act on the N-methyl-D-aspartate receptor as co-agonist and agonist, respectively)
and increasing evidence links D-amino acids to different pathological states.

Methods:

Determination of D-amino acids levels in blood is mainly based on enantiomeric
separations by high performance liquid chromatography. Because of the low amount
of D-enantiomers compared to the corresponding L-amino acids and the high background
noise associated with biological matrices, positive and negative controls are absolutely
required to obtain reliable values.

Results:

Altered levels of D-serine in blood have been reported in several neurological
and psychiatric disorders: it has been proposed as promising biomarker in schizophrenia,
Alzheimer’s disease, and amyotrophic lateral sclerosis. Indeed, D-serine levels seem an
appropriate predictor of anti-depressant response in major depressive disorder and post--
traumatic stress disorder, as well as a prognostic biomarker of early cognitive decline, especially
when considering D-serine and D-proline levels simultaneously. Furthermore,
D-amino acids seem useful biomarkers for pathologies not related to the central nervous
system, such as pancreatic cancer and chronic kidney diseases.

Conclusion:

This is the first review focusing on the determination of blood levels of Damino
acids as diagnostic and prognostic biomarkers. The experimental evidence of involvement
of D-amino acids in various physiological pathways suggest investigating
their levels in additional pathologies too, such as diabetes mellitus. In conclusion, the levels
of D-amino acids in blood may represent novel diagnostic peripheral biomarkers for
various disorders. Further studies are required to standardize/automatize the determinations
and for confirming their clinical effectiveness.
The Use of Berberine in Diabetes and Metabolic Syndrome: Two Sides of
the Same Coin. A Bibliometric Analysis
Authors: Infantino Vittoria , Riva Antonella , Petrangolini Giovanna , Allegrini Pietro , Perna Simone , Iannello Giancarlo , Peroni Gabriella , Gasparri Clara , Rondanelli Mariangela
Published: November 2021

:

The increased prevalence of obesity, metabolic syndrome and type 2 diabetes has
prompted scientists to look for new active and safe molecules that may help the prevention of metabolic
disorders: hyperglycemia, insulin-resistance and dyslipidemia. Berberine is an alkaloid
compound derived from plants, and it is largely used in traditional Chinese medicine. The aim of
this study is to investigate in SCOPUS and Web of Science (WOS) databases how the scientists
focused on the use of berberine against metabolic disorders, in human subjects. We carried A bibliometric
analysis of scientific literature and performed 2 searches: 1) “Berberine” AND “Diabetes”
AND “Diabetes Type 2”, 2) “Berberine” AND “Metabolic Syndrome”, both in ARTICLE
(Title/Abstract/Keyword) with a time limitation of 1st January, 2000 through 31st December,
2018, with the filter on “HUMAN” AND/OR “HUMANS”. The research sorted out 500 papers,
finding about 300 (60 %) in the first search definition and 200 (40 %) in the second. The refined
research sorted out 46 papers regarding the use of berberine in diabetes, and 40 articles on the use
of the alkaloid compound in metabolic syndrome. For both topics, we found increasing interest
between 2008 and 2009, with citation trends in a constant crescendo in the overall period studied.
These findings underlined that berberine is a safe and interesting botanical compound, especially
against chronic-metabolic disorder that affects billions of people globally, and emphasized that
scientists are interested in searching for long-term therapies that show no major adverse effects.
Acute Myocardial Infarction and Cardiogenic Shock Interventional Approach
to Management in the Cardiac Catheterization Laboratories
Authors: Tehrani Behnam N. , Damluji Abdulla A. , Batchelor Wayne B.
Published: November 2021

:

Despite advances in early reperfusion and a technologic renaissance in the space of mechanical
circulatory support (MCS), cardiogenic shock (CS) remains the leading cause of in-hospital
mortality following acute myocardial infarction (AMI). Given the challenges inherent to conducting
adequately powered randomized controlled trials in this time-sensitive, hemodynamically
complex, and highly lethal syndrome, treatment recommendations have been derived from AMI patients
without shock. In this review, we aimed to (1) examine the pathophysiology and the new classification
system for CS; (2) provide a comprehensive, evidence-based review for best practices for
interventional management of AMI-CS in the cardiac catheterization laboratory; and (3) highlight
the concept of how frailty and geriatric syndromes can be integrated into the decision process and
where medical futility lies in the spectrum of AMI-CS care. Management strategies in the cardiac
catheterization laboratory for CS include optimal vascular access, periprocedural antithrombotic
therapy, culprit lesion versus multi-vessel revascularization, selective utilization of hemodynamic
MCS tailored to individual shock hemometabolic profiles, and management of cardiac arrest. Efforts
to advance clinical evidence for patients with CS should be concentrated on (1) the coordination
of multi-center registries; (2) development of pragmatic clinical trials designed to evaluate innovative
therapies; (3) establishment of multidisciplinary care models that will inform quality care
and improve clinical outcomes.
Reducing Vehicle Submersions and Consequent Fatalities on Highway I-75 in Florida (Alligator Alley): Effectiveness of a Cable Safety Barrier System
Authors: McDonald Gerren , Giesbrecht Gordon G.
Published: November 2021

Objective:

We evaluated the effectiveness of a Cable Safety Barrier (CSB) system in preventing Run-Off-Road (ROR) Vehicle Immersions (VIs) and fatalities in canals along the I-75 freeway (Alligator Alley) in Collier County, Florida. The CSB system, which runs along both sides of the 80-km stretch of freeway and was installed between 2003 and 2004.

Methods:

Data from the Fatal Analysis Reporting System (FARS) were used to compare annual VIs and VI fatalities between pre-installation of the CSB system (1995-2002) to post-installation (2005-2012). As well, post-installation data from the Florida Department of Transport (FDOT) (2007-2011) and police reports were reviewed to determine the number of, and manner in which, vehicles were either contained by, or crossed, the CSB by either penetrating or overriding the barriers.

Results:

Pre- to post-installation, total accidents increased from 81.4/y to 106.2/y, accidents resulting in VIs decreased from 13.8% to 2.4%, and accidents resulting in VI fatalities decreased from 3.4% to 0.4% (FDOT). Fatal vehicle immersions decreased from 2.4/y to 0.9/y (P<0.01) and vehicle immersion fatalities decreased from 3.3/y to 1.4/y (P<0.05) (FARS). Post-installation, 531 accidents occurred with 110 ROR vehicles travelling towards the canals; 91 vehicles contacted the CSB with only 14 vehicles (15.4%) penetrating the barrier, and 7 (7.7%) overriding the barrier (FDOT).

Conclusion:

The CSB system along I-75 in Collier County dramatically decreased ROR vehicles from reaching the parallel canals, and consequent vehicle immersion fatalities. Results support the installation of lateral CSB systems on other high-risk roadways to reduce ROR crashes into water, or with other secondary hazards.
Trends in economic development and education of future economists
Authors: Filippova Olga Vladimirovna , Grigoriev Alexander Vladimirovich , Murzagalina Gulnaz Minnulovna , Sorgutov Ilya Valerievich , Latifzoda Dilovar Nazrishoevich , Kalimullin Dilovar Dilovarowish
Published: November 2021

It is known that the human factor is one of the most important production factors contributing to economic growth, interest in investing in education has increased.  In modern conditions, recognition of the effective role of investment in education in achieving comprehensive economic and social development has intensified. Many Governments have realized the value of investing in education and the need to create knowledge based on the benefits of economic growth. The profession of an economist in modern conditions is a rather promising area of training in higher education. Of particular interest in modern conditions is the need to analyze the existing economic conditions, when the epidemic of coronavirus infection radically changed the established trade and production ties. For this reason, the need to educate and train future specialists in the field of economics, who possess both theoretical and practical knowledge, is quite high, since the future of many countries of the world depends on them and they will be able to develop the necessary anti-crisis plan for states to break the economic impasse.
Open access information as a platform for sustainable development
Authors: Mohanan Neethu , Thanuskodi S.
Published: November 2021

Open Access (OA) literature is digital, online, free of charge, and free of most copyright and licensing restrictions, what makes it possible are the internet and the consent of the author or copyright holder. In most fields, scholarly journals do not pay authors, who can, therefore, consent to OA without losing revenue. In this respect, scholars and scientists are very differently situated from most musicians and movie-makers, and controversies about open access to music and movies do not carry over to research literature. Open access is entirely compatible with peer review, and all the major open access initiatives for scientific and scholarly literature insist on its importance, just as authors of journal articles donate their labor, journal editors, and referees participating in peer review. The study shows that out of 456 respondents considered for the study 203 [44.5%] belongs to Arts, 169 [37.1%] belong to Science, 33 [7.2%] Education and 51 [11.2%] belongs to Management. The findings of the study also show that out of 456 respondents considered for the study among which 81 [17.8%] belong to the M. Phil program, 102 [22.4%] belong to Ph.D. Program and 273 [59.9%] are faculty members.
impact of technology on teaching and teaching English to elementary school students
Authors: Erbas İsa , Çipuri Ramadan , Joni Altjon
Published: November 2021

This study reveals the impact of technology on teaching and teaching English to elementary school students, and shows how technology can help the process teaching and learning. The aim of the study is to show the importance of technology and to present the main points of teaching with technology. To have a wider understanding about the topic a survey and the overall observation is conducted in three elementary schools. The data are collected by using qualitative and quantitative research methods, using questionnaires with 400 elementary school students and the observations in the classrooms. The study was completed using primary data which were the questionnaires and the secondary data which were books, journals, articles and different websites. This study provides important information about teaching English with technology and how to integrate technology in everyday teaching. It helps teachers and educators understand technology and improve teaching.
Olympic rule 50
Authors: Chanda Subhrajit , Sahoo Sidheswar , Sahni Shruti
Published: November 2021

In the Tokyo Olympics, Raven Saunders, Bao Shanju and Zhong Tianshi were questioned by the IOC and got warnings due to their “performance of political demonstration” at the Olympic podium. We saw something similar during the 2012 London Olympic Summer Games when an indigenous boxer of Australia, Damien Hooper, was nearly disqualified from the Olympic competition for entering the ring wearing the Aboriginal flag shirt of Australia. The Olympics has had a history of maintaining a hypocritical form of political neutrality over the years. The Olympic Charter talks about sport being an essential medium in advancing the human rights of various individuals from different countries. However, it also chooses to stay neutral and gives preference to host nations. “Freedom of opinion and expression”, is a fundamental right enshrined in core international and regional human rights treaties and national laws. But it is also to be taken note that this freedom is restricted due to the “legitimate aims” of these treaties and laws. The Olympic Charter has followed suit and enacted a certain rule that prevents athletes from making demonstrations at the Olympic sites under the threat of disciplinary sanctions.
Impact of inquiry-based English teaching through digital applications on primary schoolchildren's reading comprehension and autonomy in pandemic situation
Authors: Pipia Ekaterine , Chikovani Irina
Published: November 2021

Considering the urgency of integrating technologies in the contemporary classrooms, the aim of the presented study has been shaped to outline the impact of inquiry-based English language teaching through digital applications on primary learners’ reading comprehension and autonomy development during a pandemic outbreak of COVID-19. The research context has been designed in a quantitative manner to analyze experiment results and compare control and treatment group learners’ reading comprehension and academic achievement levels as well as to measure primary schoolchildren’s level of autonomy before and after the treatment. The subjects’ autonomy level, curiosity and interest in reading through digital applications before and after the experiment have been evaluated through pre and post-experimental questionnaires. Learning processes of two experimental and two control groups were compared to create four research contexts for the study. Discrepancy between inquiry-based teaching through a digital library and a traditional way of teaching reading has been emphasized in the study results. The obtained data has been analyzed using SPSS to compare the academic performance results. The study revealed that inquiry-based English language teaching through digital applications highly enhanced the primary learners’ academic performance in reading and increased their motivation level to study independently.
Formalisation of agricultural research
Authors: Holikova Olena
Published: November 2021

As an independent component of modern research in natural sciences, branch research developed as a result of the accumulation of knowledge from three spheres of public activity – agriculture, branch-specific education, and agricultural research – under the influence of a complex interaction of many external factors. The purpose of this study is to investigate the initial stage of formalization of agricultural research as a branch of natural sciences with the development of corresponding sign-symbolic systems and terminology. Based on the study of printed and archival research of the Imperial Free Economic Society (IFES), adjustments were made to the scientific periodization of the history of research as a branch of knowledge, considering the personalized contribution of its luminaries. Forgotten or little-known studies of pioneers of Ukrainian research – the IFES members: Swiss mathematician L. Euler; Russian scientist of Swedish origin, botanist and chemist E.G. Laxman; a native of Chernihiv Region, Professor of agriculture V. P. Prokopovich, and others were introduced into scientific discourse. The present paper analyses the areas of diverse research activities in agriculture, which were conducted by IFES figures at the early stages of the first scientific and economic association in the Russian Empire.
Communicative sabotage, suicide and avoidance as evidences of communicative discomfort
Authors: Koroliova Valeria , Hurko Olena , Popova Iryna , Holikova Nataliia , Maiboroda Nataliia
Published: November 2021

Purpose of the study: The purpose of the article is to compare and distinguish between the communication phenomena of sabotage, suicide, and avoidance displayed in the speech of characters of modern Ukrainian plays; to define them as communicative tactics that do not always violate communicative comfort and lead to conflict in communication; to characterize the main communicative goals and maxims affected by these communicative tactics. The key methods of the study, in addition to general scientific ones, were such dedicated linguistic methods as contextual and situational, speech and action analysis of communicative sabotage, suicide, and avoidance, as well as the method of structural and pragmatic analysis to provide characteristics of speech abnormal behavior of characters in modern Ukrainian plays, to identify of the consequences of communicative sabotage, suicide, and avoidance. The tactics violating the rules of the communication code are communicative sabotage, communicative suicide, and communicative avoidance. Communicative sabotage is mainly used by characters in a negative psychoemotional state as a way to express irritation and contempt, which causes changes in the focus of communication and hinders the achievement of the objective, informative and communicative goals of communication.
Peculiarities of psychological assistance in overcoming the consequences COVID-19
Authors: Melnychuk Tetiana , Grubi Tamara , Alieksieieva Svitlana , Maslich Svitlana , Lunov Vitalii
Published: November 2021

The urgency of the study is due to the appearing of an emergency caused by an extremely dangerous outbreak of the COVID -19 pandemic. Every emergency, especially one which threatens health, is characterized by increased anxiety and depression among the population, causes chronic emotional disorders and requires providing psychological and psychosocial assistance to the individual. In this regard, this article aims to disclose and summarize theoretical and empirical research that will help identify the factors that shape the appropriate resource strategies for the development of resilience in overcoming the consequences of COVID - 19. At the same time, this study revealed the role of resilience as a potential protective factor for mental health during an outbreak of the COVID - 19 pandemic. The leading method of research is theoretical and methodological analysis, comprehension, comparison, classification and generalization of the main provisions of bibliographic sources that are relevant to the problem and purpose of the study. The article presents the factors influencing resilience in the individualovercoming the consequences of COVID - 19 taking into account the world experience. The main approaches to providing psychological assistance to a person in difficult life circumstances caused by a pandemic are identified.
After-covid development of services in the framework of sustainable development
Authors: Zharova Liubov , Raksha Natalia , Spitsyna Anhelina , Karolop Olena , Mirzodaieva Tetiana
Published: November 2021

The COVID-19 epidemic has hit the world economy hard, leaving no industry without consequences. The travel and tourism industries have been hit hardest by partial and complete lockdowns around the world. Exit from the recession and recovery of the sector should take place in the format of a new normal. In the framework of this study, it was argued that another framework for the development of tourism and hospitality is sustainable development. The necessity of rethinking the industry in the direction of sustainability is substantiated in connection with nature conservation, reassessment of the socio-cultural environment, and the benefits of active participation in the economy and local development. Emphasis is placed on the need for a solution that is primary - rethinking or rapid recovery. Underlined, that sustainable tourism should have a positive impact by improving the livelihoods of local communities. The most important thing is the employment of locals in the tourism business. Ensuring their financial security is important, especially during periods such as the decline in tourists caused by the pandemic. Sustainable tourism is financially profitable and profitable for stakeholders.
The first famine in Ukraine was organized by the communist regime of Russia in 1921-1923
Authors: Cherneha Petro M. , Cherneha Andriy P. , Baranova Natalia V. , Mokhnatyuk Ihor O. , Oblovatska Nataliia O.
Published: November 2021

The urgency of the study necessitates participation in the coverage of wars of aggression, which require participation in the struggle against four members of Lenin to replenish the power of the Ukrainian People's Republic, as well as the establishment of a communist regime that helps mass terror and voting in Ukrainian organizations. The purpose of the articles is to reveal the main forms, methods and means of the Russian communist regime's next turn of Ukrainian lands, the overthrow of the independent UPR, total increase of agricultural and industrial products that use mass terror and food dictatorship, which caused the terrible Holodomor. To solve the problems, chronological, historical-legal, historical-comparative, structural, analytical-critical and statistical methods are used, which contribute to the objective and comprehensive study of the problem. The results of the study: a critical analysis of the ideological and political principles of decrees, resolutions, directives and orders of the Central Committee of the RCP (B) and the RSFSR SNC, which testified to their purposeful content and nature of the Russian Bolsheviks' aggressive policy towards Ukraine.
The importance of state ensuring the right of citizens to quality medical care in the conditions of COVID-19 vaccination
Authors: Artemenko Olena , Krupnova Lubov , Kurylo Lіudmyla , Kovalova Svitlana , Kniazka Liliia
Published: November 2021

The article analyzes the state guarantee of the right of citizens to quality medical care in terms of vaccination from COVID-19. It is determined that in today's conditions it is extremely important to ensure the proper functioning of health care, the provision of quality medical services which in turn will guarantee proper medical care. The state must provide the citizens of Ukraine not only with the vaccine, but also with reliable information about the need for vaccination. It turns out that the small number of vaccinated in Ukraine is not only due to the slow pace of procurement and vaccination, but also the lack of awareness of citizens about all the benefits of the need for vaccination. It is concluded that the positive in today's conditions are: the efforts of the legislator still not to influence the subjective choice of every resident of Ukraine on the need for vaccination; regulatory support of the Center for Public Health, which in turn will strengthen the network of regional Centers for Disease Control and Prevention (CCP); creation of a Roadmap for the introduction of a vaccine against acute respiratory disease COVID-19 caused by the coronavirus SARS-CoV-2.
alienation phenomenon and the communicative model of the human society evolution
Authors: Chursin Mykola M. , Siliutina Iryna M. , Smolina Olha O. , Ukhov Oleksandr S. , Petrenko Maksym O.
Published: November 2021

The subject of research is the large-scale alienation as a social phenomenon. The aim of this work is the consideration of individual symptoms and areas of alienation in the history of mankind and in the modern information society, and the disclosure of its logic and patterns. Methodologically, the study is based on the historical, information and cybernetic approaches. The paper points to a positive feedback between the amount of knowledge in alienated form and figures of society, the development of its comprehensive intelligence. The number of stages and directions of alienation are indicated. Interaction between the material and direct forms of alienated knowledge with the formation of a positive feedback between them is marked. A number of forms of alienated knowledge that appeared in the last two centuries are listed. New forms of exclusion, which exist in the form of artificial intelligence, robotics, and global computer networks, are analysed. The question of the limits of alienation as a process in the context of the paradigm of the limits of destruction is discussed.