bluuebunny/crossref_metadata_2025 huggingface dataset:
Terrorism and Government Budget: An Analysis of the Impact of Boko-Haram on Budgeting Processes in Nigeria
Authors: Adinoyi Julius , Ouma Martin , Nzau Mumo
Published: June 2023

Stable countries have tried to adequately deliver public goods and services to enhance economic governance. However, countries faced with terrorism in Africa cannot adequately check, advocate, and enable the delivery of public financial management (PFM). Systems theory was used to underscore the complex interactions between budget processes and terrorism. The activities of Boko-Haram in North-eastern Nigeria have disrupted public activities and affected key stakeholders’ involvement in the budget process, availability of budgeting information and budget performance. This study interrogates the impact of Boko-Haram on budgeting processes. The mixed research design was informed by 47 interviewees and documented studies. A diagnostic test was conducted on variables to confirm their reliability, validity and normality. Likert scale was used to find out the opinions of the interviewees. Descriptive and inferential analysis was adopted in this research. With a significant regression model (p-value <0.05), the analysis shows that terrorism accounts for 89% variation in budget execution. The authors noted fewer scholarly efforts to interrogate how terrorism undermines budgeting as an aspect of PFM in economic governance. Hence, this paper recommends more research in this subject area, particularly in other terror affected countries in Africa. This paper advocates for increased policy support by enhancing public accessibility of budget documents, engendering consultative forums for citizens' participation in the budget process in secure locations, and timely budgetary reports and audits by relevant government agencies
Beef handling practices at Abattoirs and Butcher shops in Uganda: implications for meat safety and health of consumers
Authors: Kyayesimira Juliet , Muheirwe Florence
Published: June 2023

Proper beef handling contributes to achieving sustainable development goals 3 (good health and well-being) and 12 (sustainable consumption and production patterns). This is because it ensures the safety of meat and consumers’ health. However, the meat sector is still underdeveloped in most African countries. In addition, there is limited research addressing meat safety challenges. In Uganda particularly, in the recent past, there was whistle-blowing over contaminated beef on the market, indicating a  loophole in food safety. Despite this, studies focusing on beef handling practices have remained scanty. Thus, this study aimed to examine beef handling practices at the abattoirs and butcher shops in Uganda's Central, Western, and Eastern regions. A mixed-methods approach was employed to collect data through a survey, in-depth interviews, and on-site observations. Findings revealed that beef handling practices were poor at abattoirs and butcher shops and that most facilities for safety measures were lacking or inadequate. Only 3% of the respondents had cold room storage facilities, and meat spoilage was relatively high (85.3%). Appropriate knowledge of meat safety among abattoir and butcher operators was inadequate, contributing to low compliance with food safety guidelines. Inappropriate handling practices and poor handling facilities may put consumers at a health risk. The study recommends that responsible authorities should ensure compliance mechanisms and sensitization initiatives are prioritized.
Study of Reaction Mechanisms in α + 69Ga reaction at ≈10 – 50 MeV
Authors: Amanuel F. K.
Published: June 2023

The excitation functions of 69Ga(α, n)72As, 69Ga(α, 2n)71As, 69Ga(α, 3n)70As, 69Ga(α, x)69Ge, 69Ga(α, x)68Ga and 69Ga(α, x)67Ga reactions produced in the interaction of α-projectile with 69Ga-target were studied at ≈ 10-50 MeV. The produced nuclei were different isotopes of As, Ge, and Ga, some of which have important medical applications. The theoretical model predictions were based on the statistical code COMPLETE, and the predicted results were compared and discussed with existing experimental data. Good agreement between the theoretical predictions and experimental results were obtained. Pearson's relational statistics showed moderate to strong positive correlations between the theoretically predicted and experimentally measured reaction cross-sections. Furthermore, the present investigation revealed significant pre-compound contributions in the studied energy range. Therefore, it is important to consider the admixture of pre-equilibrium and equilibrium modes of reactions when predicting the reaction cross-sections.
Assessment of nitrate, trace elements and bacterial contamination of groundwater in ilora area of southwestern nigeria
Authors: Akinfemiwa Akanbi Olanrewaju , Kofoworola Akinseye Eniola
Published: June 2023

Assessments of groundwater pollution parameters were carried out in groundwater samples collected from selected shallow hand-dug wells across Ilora township. The analysed parameters were nitrate, trace elements including, iron, cobalt, chromium, manganese, zinc, arsenic, cadmium and lead, and bacteria count in water; using spectrophotometric method, HM Metalyser 5000 and multiple tube techniques respectively. The pH of the samples was between 6.4 and 7.6 and TDS range was 50 - 640 mg/l. The concentration of nitrate (NO3) in water was 12.8 - 274 mg/l. For trace elements concentrations in µg/l   ; iron (Fe): 150 – 880, Cobalt (Co): 1 – 100, Manganese (Mn): 0.01 - 140, Chromium (Cr): 0.01 – 0.31, Zinc (Zn): 1.86 - 9.97, Arsenic (As): 3.11 - 20.80, Cadmium (Cd): 0.71 - 4.76, Lead (Pb): 1.00 – 6.82. Based on the average concentration of the trace elements the order of abundance was Fe > Co > Mn > As > Zn > Pb > Cd > Cr. Total coliform count (TCC) in groundwater samples were between 18 and 370 cfu/100mL.  From the evaluation of the degree of association between the parameters, a moderate to strong positive relationship occurred between Fe/Mn (0.59), Fe/Cr (0.85), Fe/TC (0.56), NO3/Co (0.56), NO3/Mn (0.48), NO3/Cd (0.51) and Mn/Pb (0.85). Presence of coliform bacteria in the groundwater samples indicated fecal contamination from surface environment. Comparing the parameters with guideline standards for drinking water, most of the hand-dug wells are contaminated with nitrate, five wells were contaminated with either arsenic and/or cadmium, while water from some of the wells may have objectionable taste due to high iron content. The high values of cadmium and arsenic in some wells are harmful to human health and appropriate treatment is needed. For bacteria contamination, deeper wells are recommended, and the water should to be treated and boiled prior to consumption.
Impacts of climate variability on the production of Dwarf x Tall and Tall x Tall coconut (Cocos nucifera L.) palm hybrids planted on the coast in Côte d'Ivoire
Authors: Agoh Charly Fernand , Saley Mahaman Bachir , Lekadou Tacra Thierry , Yao Saraka Didier Martial , Coffi Pierre-Marie Janvier , Hala N’klo François , Goula Bi Tié Albert
Published: June 2023

The Ivorian coast is the main coconut production area where agriculture is mainly rainfed. However, in this area, climate variability poses a great threat to the growth and sustainable development of agriculture. This study aimed at highlighting the impacts of climate variability on the production of the most popular Dwarf x Tall and Tall x Tall coconut palm hybrids in the world. It is based on the evaluation of the production of the hybrids from statistical tests (ANOVA, STUDENT's T-test at 5%) and the results of the standardized precipitation and evapotranspiration indices (SPEI) during the period of 2009 to 2018 of the study area. The results obtained revealed that the NJM×GOA+ hybrid was significantly differentiated by its good production potential of bunches (10 bunches), fruits (151 nuts) and copra (3.69 t). The maximum fruit production per year was observed in the Dwarf × Tall hybrids (101 nuts). The highest mass productions of copra per tree and copra per hectare were recorded in the Tall × Tall hybrids. The maximum productions of the ten hybrids were observed in 2012, 2015 and 2018 and the lowest in 2014 and 2017. Productions gradually increase or remain stable for consecutive wet years (2009 to 2011) prior to harvest. The onset of drought in one year (2012, 2013, 2015, 2016) and pronounced for two consecutive dry years (2012 to 2013 and 2015 to 2016) prior to harvest significantly decrease the level of production. These cumulative effects of drought are most pronounced in NRC×GRL+, NRM×GTN, NJM×GD001, NJM×GD002, and NJM×GD003 hybrids. NJM×GOA+, GVT×GTN, GSL×GTN, NRM×GVT, and NVS×GVT hybrids are developing abilities to express themselves better under this climate variability. They could be taken into account in the crop improvement program and proposed to growers to improve the yield of coconut trees under rainfed conditions.
Disponibilité et valorisation des épluchures de manioc en alimentation animale en Côte d’Ivoire : cas de la commune de Yamoussoukro
Authors: Kobenan Kouakou N’guessan Stanislas , Angbo-Kouakou Cho Euphrasie Monique , Saoré Kouassi Arsène , Kouakou N’Goran David Vincent
Published: June 2023

En Côte d’Ivoire, la transformation agro-alimentaire du manioc engendre des épluchures dont la valorisation semble insatisfaisante dans plusieurs villes du pays tel que Yamoussoukro. Afin d’estimer les quantités d’épluchures collectées et d’identifier ses différents modes de valorisation dans la commune de Yamoussoukro, une enquête socio-économique a été réalisée auprès des transformateurs du manioc, des collecteurs et des utilisateurs d’épluchures. Il en ressort que les 46 transformateurs enquêtés dégagent une quantité estimée à 1 154,95 tonnes d’épluchures par an. Quant aux 5 collecteurs rencontrés, ils commercialisent 2 344 tonnes par an. Les épluchures sont valorisées chez les porcs, les bovins et ovins/caprins après avoir subies ou non des méthodes de traitement comme le séchage au soleil, la découpe et ou l’ajout de sel ou associées à d’autres sous-produits agricoles tels que : le son de maïs et de riz, la farine basse de riz, les épluchures de banane, d’igname, la papaye, la drêche de brasserie et le remoulage d'anacarde. Compte tenu des quantités d’épluchures et des besoins importants en alimentation animale, la mise au point d’un meilleur traitement de ces épluchures devrait améliorer significativement les revenus des transformateurs et la productivité des animaux.

In Côte d'Ivoire, the agro-food processing of cassava generates peelings whose valorization seems unsatisfactory in several cities of the country including Yamoussoukro. In order to estimate the quantities of peelings collected and to identify the different ways in which they are used in the commune of Yamoussoukro, a socio-economic survey was conducted among cassava processors, collectors and users of peelings. The 46 processors surveyed produce an estimated 1,154.95 tons of peelings per year. As for the 5 collectors interviewed, they market 2,344 tons per year. The peelings are valorized in pigs, cattle and sheep/goats after having undergone or not treatment methods such as sun-drying, cutting and/or addition of salt or combined with other agricultural by-products such as: maize and rice bran, rice flour, banana peelings, yam peelings, papaya peelings, brewer's grains and cashew nut milling. Given the large quantities of peelings and the high feed requirements, the development of better processing of these peelings should significantly improve the income of the processors and the productivity of the animals.
Parboiling effect on the rheological characteristics of Sahel 108, 328 and 329 rice varieties grown in Senegal River Valley
Authors: Sarr Fallou , Diouf Abdou , Faye Omar N. , Maganga Stephany E.A.T. , Fall Mariama , Sambe Mokhtar , Guiro Amadou Tidiane
Published: June 2023

In order to help State to ensure food security of the populations, technologies for substituting wheat flour with flour from local food resources such as rice are used in bread making. The aim of this study was to determine the rheological behavior of pastes obtained by incorporating parboiled and non-parboiled rice flour in the bread-making process. The results obtained revealed that parboiling improves the tenacity of the mixed wheat (85%) and rice (15%) paste. Indeed, the parboiled Sahel 328 and Sahel 329 rice varieties would give a tougher mixed paste (P/L = 1.24±0.030; 1.28±0.020 respectively) and closer to that of 100% wheat (P/L= 1.13±0.050). The incorporation of parboiled Sahel 329 rice flour resulted in a paste with a swelling index closest to that of the control (WS). The results also indicated that all the parboiled rice studied composite flours had satisfactory baking strength. Of all studied varieties, Sahel 329 when parboiled, gave the closest rheological properties to the control (100% wheat). In addition, we can consider from this study, the alternative use of rice in bread-making supports the idea that rice would be a better vehicle than the soft wheat flour used for iron and folic acid fortification in Senegal.
Implementation framework for energy efficient routing in wireless sensor network
Authors: Prithi S. , Sumathi S.
Published: June 2023

In recent years, designing of WSN becomes the leading domain for many researchers. In this paper an automaton system is suggested that dynamically  monitors and studies the behaviors of the network environment to detect the malicious activities that occur in the network, to identify the attacked nodes  and dead nodes in the wireless sensor network, and to transmit the message in the optimized route. The automaton system prevents the attacked  and dead nodes from affecting the wireless sensor network. Computational Intelligence technique such as the PSO algorithm is used along  with the automaton system so as to obtain the optimized route from the set of available paths. Once the optimized route is obtained the message is  transmitted through this optimized route. The transmission takes place at a high rate since the path does not contain dead and attacked nodes, as well as  the energy consumed by the optimal path will be minimal. Thus, the proposed model improves the utilization of energy, improves throughput,  reduces end-to-end delay, and enhances the lifetime of the network.
Linear annular antennas array design by evolutionary algorithms: A comparative study
Authors: Chaker Hichem , Mehadji Abri , Badaoui Hadjira
Published: June 2023

This paper exposes a comparative study that was made between the adaptive particle swarm optimization (APSO) and the hybrid model genetical swarm optimizer approaches (GSO) for the synthesis of 1-D equally spaced annular ring antenna arrays for both TM11 and TM12 modes. The synthesis of 1-D uniform antenna arrays is designed as a mono objective problem. The employed optimization techniques are compared in terms of convergence rate and side lobes level reduction. Several original numerical results are provided to demonstrate the performance of the proposed techniques. The results reveal that the suggested array antenna synthesis approach using genetical swarm optimizer outperforms the adaptive particle swarm optimi zation in terms of side lobes level reduction and convergence rate.
Toxicological screening method by HPLC-DAD with local spectral library and "home-made" internal standard
Authors: Sobhi Khaled , Mélaïne Souhila , Abdaoui Abderrahmane , Mammar Mohamed
Published: June 2023

A liquid-liquid extraction technique and HPLC-DAD method using a C18 column, 5μm (150x4.6mm i.d.) were developed for a toxicological drug screening. A home-made “N-acetylparoxetine” is used as internal standard. A local UV spectra library of over 130 drugs and some of their metabolites was created. This library covers the main therapeutic classes involved in intoxication cases. The developed procedure is successfully applied to different biological samples (serum, urine, gastric fluid and post mortem whole blood) and allows rapid and simultaneous detection and identification of a large number of substances and their semi-quantification in serum.
Decadal analysis of temporal variability in rainfall trends in Ogbomosho
Authors: Suleman Kamaldeen Olasunkanmi , Sunmonu Lukman Ayobami , Àlàgbé George Atilade , Sheu Akeem Lawal , Rasaq Suliat Kemi
Published: June 2023

Ten-year (2009-2018) monthly rainfall data was obtained from the Nigerian Meteorological Agency (NIMET). The data was processed and analysed using OriginPro 8.5 software. Statistical tools such as standard deviation and Coefficient of Variation (CV) were used for data presentation while analyses were done using the Mann-Kendall and Sen’s slope of linear regression to examine variations across the months and years. Results revealed higher values around July and September while lower values were recorded around December and January. Seasonal variability shows a remarkable increasing trend with the exception of post-wet which recorded an insignificant downward trend. The Mann-Kendall and Sen’s slope estimator analyses revealed both downward and upward trends in rainfall the study period and the changes are strongly marked for certain years and less for others. This result would contribute significantly to the effective management and sustainable development of the social economic activities which are heavily rain-dependent, within the study area.
Statistical study and analysis of annual rainfall in the Naama region (Algeria)
Authors: Boualem Abdelkader
Published: June 2023

Knowing the recent evolution and variability of the climate in arid and semi-arid regions is a necessity to anticipate what the consequences on the environments and societies of these regions could be, and thus define sustainable adaptation policies. In this modest work we studied the evolution of rainfall in an arid region. Thus, a good knowledge of the rainfall distribution both in time and in space, is essential to identify on the one hand the critical periods of drought to which the crops are exposed and on the other hand the favorable zones and the zones unfavorable. In this perspective, we have contributed to study the essential element of the balance which is the precipitations by using the statistical treatment and the analysis of the indices of dryness, also we adopted a methodology which is characterized by the Collection of the pluviometric data and creation from a computer database.

The calculation of the indices for the different stations reveals the existence of two distinct wet and dry periods. Drought years are more notable as they can set in for 4 years. There is a decrease in rainfall during this study period but it is also interrupted by other years of high rainfall in certain regions such as El Kheiter and Mecheria. It is as if the further south you go, the more the drought impact is present.
Valorization of citrus sinensis wastes for the production of orange essential oil: identification of chemical composition and antibacterial activity
Authors: Seid Lamria , Lakhdari Delloula , Belgherbi Ouafia , Laourari Ines , Golzadeh Nasrin , Chouder Dalila
Published: June 2023

The objective of this study was to extract, characterize, and examine the antibacterial properties of orange essential oil obtained from citrus sinensis peels, using hydro-distillation method. Various components of the orange oil were characterized by FTIR, UV-Vis and GC- MS spectroscopic techniques. The extracted essential oil was conformed to AFNOR standards, and had a maximum yield of 3.4% (w/w). The obtained results showed that limonene was the major bioactive components of the orange essential oil (97.14%). The essential orange oil and its dilutions in DMSO showed an excellent antibacterial activity against Staphylococcus aureus (gram-positive bacteria) with a diameter of inhibition zone superior to 40 mm. However, it was ineffective antibacterial activity against Escherichia coli and Pseudomonas aerogenes (gram negative bacteria).
Evaluation of the chemical and bacteriological parameters of well and borehole waters in the city of Natitingou in the North West of Benin
Authors: Tossou Evariste , Chouti Waris Kéwouyèmi , Osseni Sèmiyou
Published: June 2023

The general objective of this research is to study the physico-chemical and bacteriological quality of the water supply sources in the Municipality of Natitingou. The methodological approach adopted revolves around the collection of data on sources of drinking water supply, water sampling, socio-anthropogenic data. The analysis of the results shows that water resources are not very diversified and are limited to rainwater and groundwater. The factors that explain the bacteriological pollution of these waters are linked to the conditions of transport and storage of water, the environment, the almost total absence of a wastewater management system and the behavior of the population. Chemical pollution is due to chemicals used in socio-economic activities and released into nature.
Rayleigh-Benard convection study in a cavity for a shear thinning fluid
Authors: Ali Benyahia B. , Ait Messouadene N.
Published: June 2023

Rayleigh-Bénard's convection is a classic problem of heat transfer. Since the 1900s, studies for Newtonian fluids have been widely developed in this field and phenomena well understood. On the other hand, the complexity of non-Newtonian behavior makes the number of studies much lower. Among the non-Newtonian behavior, the shear-thinning fluid studies are even rarer. This work focuses on a numerical study of natural convection for a non-Newtonian fluid shear thinning, in the Rayleigh-Bénard configuration. The Carreau-Yasuda model describes the shear thinning behavior. The convective flow considered is confined in a cavity, which is subjected to a vertical temperature gradient, heated from below and cooled from above. The transport equations are discretized by the finite volume method and are solved numerically using a CFD code: "Ansys Fluent". The influence of the control parameters on the flow and heat transfer such as the Rayleigh 𝑅𝑎 number, the aspect ratio, 𝐴, the Prandtl numbers, 𝑃𝑟, the power index 𝑛 and the time constant 𝐸, are studied.
Ruin probability of insurance companies in Nigeria using model with economic environment: Pre and post capitalization analysis
Authors: Oseni B M
Published: June 2023

The behavior of the reserve of insurance firms in Nigeria from 1996 to 2011 is investigated using ruin model with economic environment. The investment portfolios are classified according to the types of returns expected: Investments with fixed returns and investments with stochastic returns. Against the usual ways of monitoring the performances of insurance companies using regression and correlation, a risk reserve model in economic environment is used. The ruin probability is determined from the integro-differential equation for the model. The results show that there has been a positive growth in the reserve before recapitalization, though the rate of growth of the reserve after recapitalization is higher.  The total probability of ruin shows that there is a drop in the probability of ruin after recapitalization. Also, the ruin probabilities show that companies are more liable to get ruined from investment than from claims after the recapitalization against the converse before recapitalization.
Effect of Ramial Fragmented Wood amendments on the germination rate (%) of durum wheat
Authors: Kerrouche I. , Bazri K.E.M. , Zeltni A.E.S. , Ouahrani G.
Published: June 2023

The presence of organic matter in agricultural soils is an important factor in assessing the conditions of the soils. BRF and Manure are energy inputs that can improve the soil. The objective of our work is to study the influence of the contribution of Rameal Fragmented Wood (RFW) and cattle manure in the presence and absence of earthworms Octodrilus complanatus on the germination rate (%) of durum wheat (Tritucum durum) of the Hedba 3 variety. The study station is located in a semi-arid zone (Constantine, Algeria). the results obtained show that the contribution of RFW or RFW mixture and cattle manure in the presence and absence of earthworms Octodrilus complanatus has a beneficial effect on the the germination rate increased by 193.35% on average in the amended plots compared to the control plots.
A DFT study of Hyper-Rayleigh Scattering (HRS) first hyperpolarizability of substituted polyene: Part (ii)
Authors: Labidi N.S.
Published: June 2023

Several DFT functionals have been carried out to study the first hyperpolarizabilities βHRS of push-pull polyene as a function the basis sets, of electron  correlation, of the size, of the frequency dispersion and the geometry. These calculations confirm the huge effects of electron correlation, the Møller– Plesset (MP2) results reproduces the values of the first hyperpolarizability obtained with the reference CCSD(T) level. Among density functional theory  exchange- correlation functionals, B3LYP, M062X, B3P86 and CAM-B3LYP are comparable to the MP2 for characterizing the dynamic first  hyperpolarizability. The TDB3LYP/6-31+G* level show that, as increasing the the separation distance (dN···N /Å) and introducing a stronger donor the  avereage BLA value decreases and the βHRS increase. In addition, a quantitative relationship was established between the first hyperpolarizability HRS    and the separation distance (dN···N /Å) at MP2, B3LYP and M062X level of theory.
Développement d’une analyse du cycle de vie dynamique pour l’évaluation des effets d’incendie industriel. Cas de la raffinerie de skikda
Authors: Chettouh S.
Published: June 2023

L'évaluation de l'impact du cycle de vie (EICV) est la troisième phase de l'Analyse du Cycle de Vie (ACV) décrite dans la norme ISO 14042. L'objectif de l'ACV  est d'évaluer l'inventaire du cycle de vie (ICV) de produit afin de mieux comprendre son importance pour l'environnement. Cependant, l’EICV exclut  généralement les effets spatiaux, temporels, les seuils et la relation dose-réponse et combine les émissions ou les activités dans l'espace et/ou le temps.  Cela peut diminuer la pertinence du résultat de la méthode. La méthodologie ACV Dynamique orientée Incendie (ACVDI) proposée dans ce travail a pour  objectif de compléter la norme internationale ISO 14042 dans le domaine des incendies, Elle consiste à combiner la méthode ACV-Incendie avec le  Modèle Numérique de Dispersion (MND). Cette méthodologie est basée sur l'utilisation du MND pour évaluer les concentrations des polluants et les  effets thermiques résultants des scénarios d'accident. Dans cette étude, la méthodologie de l'ACV dynamique - Incendie est appliquée à une étude de cas  pour le pétrole la gestion des processus de production.
Effect of aqueous infusion of Plectranthus amboinicus (LOUR) Spreng leaves on humoral immune system in rats
Authors: Silitonga Melva , Silitonga Pasar Maulim , Sinaga Erlintan
Published: June 2023

Purpose: To examine the effect of an aqueous infusion of Plectranthus amboinicus (AIP) on the immunological development of rats in response to Bacille  Calmette-Guerin (BCG) antigen induction.

Methods: Twenty-four male rats, aged 3 months, were separated into six groups. Group 1 was normal control group without treatment, whereas groups  2 and 3 were the treatment groups induced with 100 μL BCG on days 7 and 14, followed by oral administration of AIP at doses of 19 and 31.5 g/kg, respectively. Groups 4 and 5 were treated only with AIP at doses of 19 and 31.5 g/kg respectively. Group 6 was a negative control group induced with 100  μL BCG on days 7 and 14. On day 31, IgG activity, antibody titer, lysozyme activity, relative organ weight, and lung histology were determined.

Results: The results showed that IgG levels, antibody titers, and lysozyme activity were significantly elevated in groups 4, 5, and 6 compared to normal  control group (p < 0.05). Aqueous infusion of Plectranthus amboinicus and BCG had no effect on the relative weight of spleen. However, the therapy administered to rats in group 3 significantly increased their liver and lung mass (p < 0.05).

Conclusion: Aqueous infusion of Plectranthus amboinicus  leaves stimulates the immune system in BCG-induced rats.
Efficacy of apatinib on advanced ovarian cancer patients who failed first and second-line chemotherapy
Authors: Wen Aiping , Zhao Lei , Luo Le , Du Chengchao , Luo Xin
Published: June 2023

Purpose: To investigate the efficacy and safety of apatinib in the treatment of advanced epithelial ovarian cancer (EOC) patients who failed first and second-line chemotherapy.

Methods: The clinical data of 100 patients diagnosed with advanced ovarian cancer were retrospectively analyzed. They were divided into two groups,  with 50 patients in each group. One group was treated with apatinib mesylate (Apatinib group), while the other group was treated with gemcitabine (Gemcitabine group). Clinical efficacy, adverse reactions, and quality-of-life scores were were assessed, while the survival status of patients was recorded during follow-up.

Results: After treatment, the objective response rate (ORR) and disease control rate (DCR) were 24.0 % (12/50) and 70.0 % (35/50) in Apatinib group, and  12.0 % (6/50) and 52.0 % (26/50) in Gemcitabine group. In terms of adverse reactions, the incidence of hand-foot syndrome and hypertension were significantly higher in Apatinib group than in Gemcitabine group, but the incidence of nausea and vomiting, anemia, neutropenia, and thrombocytopenia were significantly lower in Apatinib group than in Gemcitabine group (p < 0.05). Follow-up results revealed the median overall survival (OS) of patients to be 10.1 and 9.0 months, respectively, in Apatinib and Gemcitabine groups. Results of the log-rank test showed that OS in Apatinib group was significantly longer than that of Gemcitabine group.

Conclusion: Apatinib demonstrates clear effectiveness and a superior safety profile than Gemcitabine in the management of patients with advanced  ovarian cancer who did not respond effectively to multiple rounds of chemotherapy.
E2F6 promotes cell proliferation and invasion in gastric cancer through the regulation of lncRNA TUSC7
Authors: Huang Xingxing , Qiao Jia , Zheng Xiaoling , Yuan Maoling , Wang Long
Published: June 2023

Purpose: To examine the regulatory effects of E2F6/long noncoding ribonucleic acid (lncRNA) TUSC7 on the progression of gastric cancer (GC), and the underlying mechanism of action.

Methods: Relative levels of E2F6 and TUSC7 in GC tissues were determined by quantitative real-time polymerase chain reaction (qRT-PCR). The influence  of TUSC7 on the overall survival of patients with GC was analyzed using Kaplan-Meier method. Interaction between E2F6 and TUSC7 was analyzed by Spearman correlation test and dual-luciferase reporter gene assay. Changes in proliferation, invasion and apoptosis of BGC823 and SGC7901 cells  regulated by E2F6 and TUSC7 were assessed. The protein levels of MMP-2 and the activity of caspase-3 were evaluated in GC cells treated with E2F6 and TUSC7 using western blot and caspase-3 kit.

Results: TUSC7 was downregulated while E2F6 was upregulated in GC tissues and cells. A negative correlation was observed between the expression levels of TUSC7 and E2F6, and a low level of TUSC7 predicted poor prognosis in GC patients. The  knockdown of E2F6 attenuated cell viability and invasion, and stimulated the apoptosis of GC cells, but these were reversed by co-knockdown of TUSC7.  In addition, knockdown of E2F6 downregulated MMP-2 protein levels, and upregulated caspase-3 GC cells, but these changes were partially reversed by  co-transfection of si-TUSC7.

Conclusion: TSUC7 is downregulated in GC, and its low level predicts poor prognosis in GC patients. E2F6 promotes  proliferation and invasion of GC cells by negatively regulating TUSC7. Therefore, E2F6/TUSC7 may be utilized as potential therapeutic targets for GC.
COLEC12 expression participates in trophoblast insulin resistance, and reverses celecoxib-mediated inhibition of COX2-PGE2 axis in gestational diabetes
Authors: Jin Beibei , Hu Mi , Chen Jie , Yu Lin
Published: June 2023

Purpose: To evaluate the contribution of collectin subfamily member 12 (COLEC12) in insulin resistance associated with gestational diabetes mellitus (GDM).

Methods: Insulin resistance was induced in human placental trophoblast (HTR-8/SVneo) cells in vitro by incubating them with 1 μM insulin for 48 h.  Expression of COLEC12 was assessed using western blot and quantitative real time-polymerase chain reaction (qRT-PCR). Distribution of glucose transporters GLUT1 and GLUT4 was visualized using immunofluorescent staining. Furthermore, the level of reactive oxygen species (ROS) was evaluated by flow cytometry.

Results: Insulin-resistant HTR-8/SVneo (IR-HTR-8/SVneo) cells showed significantly elevated COLEC12 expression (p < 0.001). Knocking down of COLEC12  in these cells led to a significant reduction in GLUT1 expression, and increase in both glucose consumption and GLUT4 expression (p < 0.001).  Furthermore, COLEC12 knockdown levels of ROS increased SOD expression in IR-HTR8/SVneo, while knockdown of COLEC12 reduced p-insulin receptor  substrate (IRS) (Ser307) protein expression, but increased p-IRS-1 (Tyr896), p-insulin receptor β (IRβ) (Tyr1361), and p-AKT levels. COLEC12 knockdown also  decreased cyclooxygenase-2 (COX-2) expression, resulting in lower prostaglandin E2 (PGE2) levels in IR-HTR-8/SVneo. COLEC12 over-expression  attenuated celecoxibinduced increase in glucose consumption, resulting in decreased COX2 and PGE2 levels.

Conclusion: COLEC12 in IR-HTR-8/SVneo  cells has antioxidant effects that protect against insulin resistance. This protective effect is achieved through the down-regulation of COX-2/PGE2. These findings provide a potential strategy for the treatment of GDM.
Sürekli Yenilenen Bir Hazine: Türk Edebiyatı Eserler Sözlüğü
Authors: KARAHAN Ali
Published: June 2023

Bilgiyi toplu olarak sunma amaçlı hazırlanan ansiklopedik sözlükler, öğrenimi kolaylaştıran başvuru kaynaklarıdır. Genel ağdaki çağdaş arama motorlarının işlevini çok önceleri gören bu çalışmalar, bilgiyi yaygınlaştırmakla kalmaz, aynı zamanda bilgiye erişimi de daha zahmetsiz kılar. Türk Edebiyatı Eserler Sözlüğü de bir ansiklopedik çalışma olmasının yanı sıra genel ağ erişimine de uygun bir projedir. Bu yönleriyle edebiyat okuru veya araştırmacısı için vazgeçilmez bir kaynak olan sözlük, Türk edebî birikiminin bütün bilinmezleriyle ve sınırlarıyla görünürleşmesini sağlamıştır. Yetkin editör ekibi, çalışma grubu ve alanında uzman yazarları sayesinde ortaya çıkan Türk Edebiyatı Eserler Sözlüğü, Türkçenin başlangıç deneyimlerinden yola çıkarak 20. yüzyılda yenileşen Türk edebiyatının ilk eserlerine kadar geniş bir kapsamı içerir. Akademik bir titizlikle hazırlanan sözlükte madde başı olan eser hakkında tanıtıcı bilgi gayet pratik, yeterli ve öz şekilde verilir. Bu incelemede Türk Edebiyatı Eserler Sözlüğü’nde, tanıtımına da hizmet edecek şekilde, Türk edebiyatını oluşturan eserlerin ne şekilde, hangi yöntemlerle ele alındığını, sözlüğün kapsam ve önemini göstermek amaçlanmaktadır.
GAMBARAN RED BLOOD CELL DISTRIBUTION WIDTH (RDW) PADA IBU HAMIL TRIMESTER II DI PUSKESMAS POASIA
Authors: Idris Sri Aprilianti , Susanti Susanti , Sari Fitrayana
Published: June 2023

ABSTRACT

Trimester II pregnant women is a pregnant woman with 15 weeks of gestation (week 13 to 27). Trimester II pregnant women often have iron deficiency anemia can affect the examination value of Red Blood Cell Distribution Width (RDW). Red Blood Cell Distribution Width (RDW) is the difference in size or extent of red blood cells. RDW changes are influenced by many factors such as anemia, renal dysfunction or liver dysfunction, hepatic dysfunction, thyroid disease, acute transfusion or chronic inflammation, neurohormonal activation, malnutrition (iron, vitamin B12 and folic acid), ethnicity, bone marrow suppression, and use of some medicines. This study aims to find out the description of Red Blood Cell Distribution Width (RDW) in Trimester II pregnant women at Puskesmas Poasia of Kendari City used analyzer hematology method. The type of this research is descriptive with sampling technique is accidental sampling technique, with the number of samples as much as 15 people. The results of a study of 15 patients of trimester II pregnant women at the Poasia Public Health Center in Kendari City, a normal RDW-SD score of 10 (66.7%) and a high of 5 (33.3%), a normal RDW-CV was 10 ( 66.7%) people and a high of 5 people (33.3%).

Keywords             : Trimester II pregnant women, Red Blood Cell Distribution Width

ABSTRAK

Ibu hamil trimester II adalah ibu hamil dengan usia kehamilan 15 minggu (minggu ke-13 hingga ke-27). Ibu hamil trimester II sering kali mengalami anemia defisiensi zat besi yang dapat mempengaruhi  nilai pemeriksaan Red Blood Cell Distribution Width (RDW). Red Blood Cell Distribution Width (RDW) adalah perbedaan ukuran atau luas dari sel darah merah. Perubahan RDW dipengaruhi oleh banyak faktor seperti anemia, disfungsi ginjal atau disfungsi hati, penyakit tiroid, tranfusi, akut atau peradangan kronis, aktivasi neurohormonal, malnutrisi (zat besi, vitamin B12 dan asam folat), etnis, tulang depresi sumsum, dan penggunaan beberapa obat. Penelitian ini bertujuan untuk mengetahui Gambaran Red Blood Cell Distribution Width (RDW) pada Ibu Hamil Trimester II di Puskesmas Poasia Kota Kendari, menggunakan metode hematologi analyzer. Jenis penelitian ini adalah deskriptif dengan teknik pengambilan sampel accidental sampling, dengan jumlah sampel sebanyak 15 orang. Hasil penelitian terhadap 15 pasien ibu hamil trimester II di Puskesmas Poasia Kota Kendari diperoleh nilai RDW-SD normal sebanyak 10 (66,7%) orang dan yang tinggi sebanyak 5 orang (33,3%), RDW-CV normal sebanyak 10 (66,7%) orang dan yang tinggi sebanyak 5 orang (33,3%) .

Kata Kunci     : Ibu Hamil Trimester II, Red Blood Cell Distribution Width
GAMBARAN KADAR KOLESTEROL TOTAL PENDERITA DIABETES MELLITUS DI RUMAH SAKIT BENYAMIN GULUH KOLAKA
Authors: Firdayanti Firdayanti , Fusvita Angriani , Irdayanti Irdayanti
Published: June 2023

Diabetes mellitus is a hyperglycemia disease charactherized by absolute absence of insulin or a relative decrease in insulin insensitivity to insulin., diseases of the eyes, kidneys and nerves. Cholesterol and diabetes mellitus have a related , where factors that can increase total cholesterol (hyperglycemia), namely nutrition, drugs, obesity and age are also factors that cause a person suffering from diabetes mellitus. This study aims to determine the picture of total cholesterol levels in people with diabetes mellitus in Benyamin guluh hospital Kolaka. The sample taken in this study is the outpatient plasma at the Benyamin guluh hospital Kolaka that was diagnosed with diabetes mellitus. In this study the number of samples studied were 30 samples as many as 30 people were obtained by accidental sampling . The results of the study were from the examination of 30 patiens with diabetes mellitus at Benyamin Guluh Kolaka Hospital. Normal kolesterol result were 11 people (37%), and abnormal 19 people (30%).

Keywords : Diabetes mellitus, Total cholesterol levels, Hyperglycemia
UJI DAYA HAMBAT FRAKSI n-HEKSAN EKSTRAK ETANOL BUAH TOMAT (Lycopersicum esculentum Mill.) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus
Authors: Sernita Sernita
Published: June 2023

Tomato (Lycopersicumesculentum Mill.) Is a vegetable plant that plays an important role in meeting community nutrition. In addition, tomatoes can also be used as medicine. The chemical content of tomatoes such as alkaloids, saponins can be as antibacterial. This study was conducted to determine whether the n-hexane fraction of tomato fruit extracts could inhibit the growth of Staphylococcus aureus bacteria. This research was conducted experimentally, tomato fruit was extracted by maceration method using ethanol 96% solvent then fractionated by partitioning method using n-hexane solvent. The n-hexane fraction was then made in concentrations of 10%, 15% and 20% with ampisillin as a positive control and distilled water as a negative control, tested using the wells method. The results showed that the n-hexane fraction of tomato fruit extract could inhibit the growth of Staphylococcus aureus bacteria with an average diameter of inhibitory zone at a concentration of 10% at 16,0 mm, a concentration of 15% at 17,4 mm and a concentration of 20% at 17,7 mm and ampisillin positive control at 27,9 mm. From the results of the One Way Anova test obtained sig value <0.05 which means that the n-hexane fraction of tomato extract with 3 repetitions of each treatment showed that the average treatment had a significant effect on the growth of Staphylococcus aureus bacteria.

 Keywords: Tomato Fruit, n-hexane fraction, Staphylococcus aureus.
A quantitative perspective on the correlation between students’ cumulative grade point average and their results in the Doctor of Pharmacy programme in Saudi Arabia
Authors: Albekairy Abdulkareem M. , Obaidat Aiman A. , Alqasomi Abdulmajeed A. , Alsayari Abdulrahman S. , Albarraq Ahmed A. , Aljabri Ahmed A. , Alrasheedy Alian A. , Alsuwayt Bader H. , Aldhubiab Bandar E. , Alrobaian Majed M. , Altwaijri Najla A. , Alkahtani Saad A. , Alotaibi Gallab H. , Alghamdi Saleh A. , Almuqbil Mansour S. , Alswelmi Farhan K. , Alahmadi Yaser M.
Published: June 2023

Background: The colleges of pharmacy in Saudi Arabia share a set of unified programme learning outcomes for their Doctor of Pharmacy (Pharm.D.) programmes. Based on this, a unified progress test for pharmacy students has been implemented over the past five years. The aim of this study is to correlate the students’ results in the test to their cumulative grade point average (cGPA).
Methods: The progress test is usually composed of 100 multiple choice questions, 30 of which cover basic pharmaceutical sciences and 70 cover pharmacy practice. The questions were selected from a question bank for this purpose prepared by the participating colleges. The test was administered online to all undergraduate students in the professional programmes of the participating colleges.
Results: The attendance percentage was approximately 72% of the total number of students enrolled in 16 participating colleges. The results indicated positive correlation between the students’ results in the test and their cGPA, however, there was some negative correlation, especially in the first professional levels of some programmes.
Conclusion: The results showed an overall good and reasonable correlation mainly for professional third and fourth year students. It was difficult to draw conclusions about the strength of the test in assessing the programme learning outcomes.
Representações sociais do judô na Educação Física: teses e dissertações em programas brasileiros de pós-graduação
Authors: Silva Vinícius Ribeiro da , Andrade Marconi Silva de , Triani Felipe da Silva
Published: June 2023

O objetivo desta pesquisa foi investigar e analisar a apropriação da Teoria das Representações Sociais enquanto referencial teórico e metodológico para o desenvolvimento de estudos acerca do judô no campo da Educação Física brasileira. Foi utilizado o catálogo de teses e dissertações da CAPES para o desenvolvimento da pesquisa. Os resultados apontaram a existência de 9 dissertações e 1 tese entre os anos de 2017 e 2021.Os principais autores foram Moscovici e Abric. Os professores de Educação Física foram os participantes mais comuns nos estudos.O teste de associação livre de palavras e o questionário correspondem aos instrumentos mais frequentemente empregados. A pesquisa mostra que os estudos sobre o Judô, na Educação Física, têm adotado pouco a Teoria das Representações Sociais na qualidade de referencial teórico e metodológico.
Padrões de jogo no sistema ofensivo: características dos jogadores de voleibol da Superliga Brasileira
Authors: Nascimento Marcos Henrique do , Batista Gilmario Ricarte , Costa Gustavo De Conti Teixeira
Published: June 2023

O objetivo do presente estudo foi o de identificar padrões de jogoofensivo no voleibol masculino por equipe, após a realização da recepção que permite o ataque organizado com todas as opções de ataque, uma vez que é nessa condição que há maior oportunidade de variabilidade para a construção ofensiva. A amostra foi composta por 22 jogos de cada uma das 12 equipes participantes da Superliga de Voleibol Masculina Brasileira de 2021-2022, sendo analisadas 5524 ações de ataque após as recepções que permitiram o ataque organizado com todas as opções. Os resultados mostraram que as equipes apresentaram padrões de jogo ofensivo conforme as características dos jogadores que compunham a rede de ataque e que a distribuição, em uma análise geral, se concentrou na zona P3, indicando que a estratégia ofensiva se mostrou alicerçada no atacante central e pouco modificou-se em relação à fase do set. A partir disso, concluiu-se que há idiossincrasias que especificam o desempenho das equipes de voleibol de alto nível.
Análise do mando de campo nos clássicos estaduais presentes em campeonatos brasileiros
Authors: Sandoval Gabriel Orenga , Gonçalves Rodrigo Baldi , Scaglia Alcides José
Published: June 2023

O presente artigo busca compreender a implicação do resultado em clássico (vitória, empate ou derrota) e sua relação com mando de campo levando em conta os três jogos posteriores, sabendo que clássico são jogos tradicionais entre equipes da mesma região. Para isto, analisou-se todos os clássicos no Campeonatos Brasileiros de 2018 a 2022. O objetivo do trabalho se pautou em observar os seguintes aspectos: resultado do clássico (vitória do mandante; empate ou vitória do visitante) e os pontos conquistados no clássico pelo mandante e visitante nos três jogos posteriores ao clássico, analisando a situação (mandante ou visitante), resultado do jogo (vitória, empate ou derrota) e os pontos conquistados do time que foi mandante e visitante do clássico. Os dados obtidos para a realização do estudo foram retirados do site Globo Esporte) e sua tabulação foi organizada no Software Microsoft Excel 2021. Primeiramente, observa-se que o mandante tem melhor aproveitamento nos clássicos com 44,44% de vitórias, seguido por 29,41% de empates e, por fim, 26,14% de vitórias do visitante. De modo geral, ganhar o clássico não significa uma promessa de vitória nos três jogos seguintes, neste campeonato. Contudo, perder o clássico na condição de mandante, prospera, na média, um desempenho pior em jogos posteriores.
Modelo Medellín. Fortalecimiento de las capacidades de innovación en ecoturismo en un Gobierno Municipal en el Perú
Authors: Saldarriaga Villegas Ana Luisa , Morales Salazar Pedro Otoniel , Rodríguez Beas Tomás Leoncio Hope , Céspedes Cáceres Gina Katherine
Published: June 2023

Considerando la necesidad de desarrollar y fortalecer las capacidades de innovación en el sector ecoturismo en un gobierno municipal en la República de Perú; surgió la iniciativa de diseñar un programa integral de gestión basado en el Modelo Medellín, el cual se expone en el presente libro; abordando en toda su magnitud la experiencia vivida en la ciudad de Medellín, el proceso de su reforma social, cultural, urbana y económica tras la aplicación de un plan de desarrollo integral que apostó por la innovación, la tecnología y la cultura del emprendimiento, es así que haciendo un análisis desde un enfoque de competitividad sistémica en el sector ecoturismo de nuestra región nos encontramos ante diversos problemas: falta de capacidad de innovación, asignación insuficiente de recursos en la economía, escasa formación de estructuras a nivel de la sociedad para una interacción estratégica, deficiente gestión y organización. Nuestro deseo es fomentar y fortalecer las capacidades de innovación, así como, un nuevo espíritu empresarial a través de un trabajo organizado tras un objetivo común: transformar el balneario de Huanchaco y otros y convertirlos en destinos turísticos dignos de una postura de calidad inminente.