bluuebunny/crossref_metadata_2025 huggingface dataset:
Event Study Design for Modeling Early Relaxation in Turkish Public with COVID-19 Vaccine
Authors: Keser Merve , Sariyer Gorkem , Kahraman Serpil
Published: September 2023

Objective:

Vaccination is crucial to fighting the coronavirus disease (COVID-19) pandemic. A large body of literature investigates the effect of the initiation of the COVID-19 vaccination in case numbers in Turkey, including the resistance and willingness to taking the vaccine. The effect of early relaxation in the Turkish public with the initiation of vaccination on new daily cases is unknown.

Methods:

This study performs an event study analysis to explore the pre-relaxation effect of vaccination on the Turkish public by using daily data of new cases, stringency index, and residential mobility. Two events are comparatively defined as the vaccination of the health personnel (Event 1) and the citizens age 65 and over (Event 2). The initial dates of these events are January 13 and February 12, 2021, respectively. The length of the estimation window is determined as 14 days for the 2 events. To represent only the early stages of the vaccination, the study period ends on April 12, 2021. Thus, whereas the event window of Event 1 includes 90 observations, Event 2 covers 60 observations.

Results:

While average values of residential mobility, stringency index, and daily numbers of cases are 15.36, 71.03, and 11 978.93 in the estimation window for Event 1, these averages are 8.89, 70.88, and 17 303.20 in the event window. For Event 2, the same average values are 9.14, 69.38, and 7 664.93 in the estimation window and 8.25, 71.12, and 22 319.10 in the event window. When 14-day abnormal growth rates of the daily number of cases for Event 1 and Event 2 are compared, it is observed that Event 1 has negative growth rates initially and reaches a 7.59% growth at most. On the other hand, Event 2 starts with a 1.11% growth rate, and having a steady increase, it reaches a 23.70% growth in the last 14 days of the study period.

Conclusion:

The preliminary result shows that, despite taking more strict governmental measures, while residential mobility decreases, the daily number of COVID-19 cases increases in the early stages of vaccination compared to short pre-periods of it. This indicates that the initiation of vaccination leads to early behavioral relaxation in public. Moreover, the effect of Event 2 on the case numbers is more significant and immediate, compared to that of Event 1, which may be linked to the characteristic of the Turkish culture being more sensitive to the older adult population.
Direct detonation initiation in hydrogen/air mixture: effects of compositional gradient and hotspot condition
Authors: Jia Xiongbin , Xu Yong , Zheng Hongtao , Zhang Huangwei
Published: September 2023

Two-dimensional simulations are conducted to investigate the direct initiation of cylindrical detonation in hydrogen/air mixtures with detailed chemistry. The effects of hotspot condition and mixture composition gradient on detonation initiation are studied. Different hotspot pressures and compositions are first considered in the uniform mixture. It is found that detonation initiation fails for low hotspot pressures and the critical regime dominates with high hotspot pressures. Detonation is directly initiated from the reactive hotspot, whilst it is ignited somewhere beyond the non-reactive hotspots. Two cell diverging patterns (i.e. abrupt and gradual) are identified and the detailed mechanisms are analysed. Moreover, cell coalescence occurs if many irregular cells are generated initially, which promotes the local cell growth. We also consider non-uniform detonable mixtures. The results show that the initiated detonation experiences self-sustaining propagation, highly unstable propagation and extinction in mixtures with a linearly decreasing equivalence ratio along the radial direction, i.e. 1 → 0.9, 1 → 0.5 and 1 → 0. Moreover, the hydrodynamic structure analysis shows that, for the self-sustaining detonations, the hydrodynamic thickness increases at the overdriven stage, decreases as the cells are generated and eventually becomes almost constant at the cell diverging stage, within which the sonic plane shows a ‘sawtooth’ pattern. However, in the detonation extinction cases, the hydrodynamic thickness continuously increases, and no ‘sawtooth’ sonic plane can be observed.
Superharmonic and triadic resonances in a horizontally oscillated stably stratified square cavity
Authors: Yalim Jason , Welfert Bruno D. , Lopez Juan M.
Published: September 2023

The response to harmonic horizontal oscillations of a stably stratified fluid-filled two-dimensional square container is examined as the forcing amplitude is increased. For the studied forcing frequency, the response flow at very small forcing amplitudes is a synchronous periodic flow with piecewise-constant vorticity in regions delineated by the characteristics emanating from the corners of the container, regularized by viscosity. The second temporal harmonic of the forced response flow resonantly excites an intrinsic mode of the stratified container, whose magnitude grows as the square of the forcing amplitude. Above a critical forcing amplitude, a sequence of pairs of other container modes are excited via triadic resonances with the second-harmonic-driven mode. The flows are computed from the Navier–Stokes–Boussinesq equations and the ensuing dynamics is analysed using Fourier techniques, providing a comprehensive picture of the transition to internal wave turbulence.
Wind turbine wakes: experimental investigation of two-point correlations and the effect of stable thermal stability
Authors: Placidi Marco , Hancock Philip E. , Hayden Paul
Published: September 2023

Wind tunnel experiments are performed in both neutral and stable boundary layers to study the effect of thermal stability on the wake of a single turbine and on the wakes of two axially aligned turbines, thereby also showing the influence of the second turbine on the impinging wake. In the undisturbed stable boundary layers, the turbulence length scales are significantly smaller in the vertical and longitudinal directions (up to 50 % and

$\approx$

40 %, respectively), compared with the neutral flow, while the lateral length scale is unaffected. The reductions are larger with the imposed inversion of a second stable case, except in the near-wall region. In the neutral case, the length scales in the wake flow of the single turbine are reduced both vertically and laterally (up to 50 % and nearly 40 %, respectively). While there is significant upstream influence of a second turbine (on mean and turbulence quantities), there is virtually no upstream effect on vertical length scales. However, curiously, the presence of the second turbine aids length-scale recovery in both directions. Longitudinally, each turbine contributes to successive reduction in coherence. The effect of stability on the turbulence length scales in the wake flows is non-trivial: at the top of the boundary layer, the reduction in the wall-normal length scale is dominated by the thermal effect, while closer to the wall, the wake processes strongly modulate this reduction. Laterally, the turbines’ rotation promotes asymmetry, while stability opposes this tendency. The longitudinal coherence, significantly reduced by the wake flows, is less affected by the boundary layer's thermal stability.
Lower Court Influence on High Courts: Evidence from the Supreme Court of the United Kingdom
Authors: Bowie Jennifer , Masood Ali S. , Savchak Elisha C. , Smith Natalie , Wieck Bianca , Abrams Cameron , Melkote Meghna
Published: September 2023

Do lower court judges influence the content of Supreme Court opinions in the United Kingdom? Leveraging original data, we analyze opinion language adoption practices of the UK Supreme Court. We advance a theory where the justices’ choices to adopt language from lower court opinions are influenced by Supreme Court-level attributes and Court of Appeal case characteristics. We uncover compelling evidence that UK Supreme Court justices incorporate language extensively from the written opinions of the Court of Appeal of England and Wales. Our findings have significant implications for opinion formulation, doctrinal development, and higher and lower court interactions within comparative courts.
Gender is conceptualized in different ways across cultures
Authors: Mazzuca Claudia , Borghi Anna M. , van Putten Saskia , Lugli Luisa , Nicoletti Roberto , Majid Asifa
Published: September 2023

Gender can be considered an embodied social concept encompassing biological and cultural components. In this study, we explored whether the concept of gender varies as a function of different cultural and linguistic norms by comparing communities that vary in their social treatment of gender-related issues and linguistic encoding of gender. In Study 1, Italian, Dutch, and English-speaking participants completed a free-listing task, which showed Italians and Dutch were the most distinct in their conceptualization of gender: Italian participants focused more on socio-cultural features (e.g., discrimination, politics, and power), whereas Dutch participants focused more on the corporeal sphere (e.g., hormones, breasts, and genitals). Study 2 replicated this finding focusing on Italian and Dutch and using a typicality rating task: socio-cultural and abstract features were considered as more typical of “gender” by Italian than Dutch participants. Study 3 addressed Italian and Dutch participants’ explicit beliefs about gender with a questionnaire measuring essentialism and constructivism, and consolidated results from Studies 1 and 2 showing that Dutch participants endorsed more essentialist beliefs about gender than Italian participants. Consistent with socio-cultural constructivist accounts, our results provide evidence that gender is conceptualized differently by diverse groups and is adapted to specific cultural and linguistic environments.
Combined effects in mixed local–nonlocal stationary problems
Authors: Arora Rakesh , Rădulescu Vicenţiu D.
Published: September 2023

In this work, we study an elliptic problem involving an operator of mixed order with both local and nonlocal aspects, and in either the presence or the absence of a singular nonlinearity. We investigate existence or nonexistence properties, power- and exponential-type Sobolev regularity results, and the boundary behaviour of the weak solution, in the light of the interplay between the summability of the datum and the power exponent in singular nonlinearities.
Energetic electron transport in magnetic fields with island chains and stochastic regions
Authors: Kostadinova E.G. , Orlov D.M. , Koepke M. , Skiff F. , Austin M.E.
Published: September 2023

This paper investigates energetic electron transport in magnetized toroidal plasmas with magnetic fields characterized by island chains and regions of stochastic field lines produced by coil perturbations. We report on experiments performed in the DIII-D tokamak, which utilize electron cyclotron heating and current drive pulses to ‘tag’ electron populations within different locations across the discharge. The cross-field transport of these populations is then inferred from electron cyclotron emission measurements and gamma emission signals from scintillator detectors. Two types of energetic particles are distinguished and discussed: non-relativistic suprathermal electrons and relativistic runaway electrons. The magnetic field topology in each discharge is reconstructed with field-line tracing codes, which are also used to determine the location and scale of magnetic islands and stochastic regions. Comparison of simulations and experiments suggests that suprathermal transport is suppressed when the tagging is performed at a smaller radial location than the location of the

$q = 1$

island chain and enhanced otherwise. Here q is the safety factor. We further demonstrate that increasing the width of the stochastic region within the edge plasma yields enhancement of the suprathermal electron transport.
The ‘Double Risk’ of Aging: Examining Vulnerability and (Un)supportive Built Environments in Canadian Cities
Authors: Biglieri Samantha , Hartt Maxwell
Published: September 2023

The confluence of rapid population aging and the overwhelming desire of older adults to age in place begs the question: Do our cities support the health and well-being of aging populations? Using a neighbourhood-by-neighbourhood approach, this macro-scale investigation explores the “double risk” that many older adults live with – the potential of being disadvantaged by socio-demographic risk factors (being older, living alone, low income) and by living in an unsupportive built environment. It is an integration of what we know about supportive built form for older adults and applies this knowledge to Canadian cities, using a spectrum approach to classifying built environments. We found that most older adults with socio-demographic risk factors are living in unsupportive built environments in Canada; however, the distribution between built environments along the spectrum and between municipalities reveals a variegated landscape of double risk. Previous research suggests that unsupportive built environments can be supplemented with services, small-scale improvements in the built environment, and larger-scale retrofitting of neighbourhoods. Since the spatial distribution of vulnerability varies greatly within the 33 Canadian cities analysed, it highlights the need for this kind of inquiry to target age-friendly policy interventions.
Moringa induces its beneficial effect via hormesis
Authors: Calabrese Edward J. , Dhawan Gaurav , Kapoor Rachna , Agathokleous Evgenios , Calabrese Vittorio
Published: September 2023

Moringa oleifera, a traditional Indian herb, is widely known for its capacity to induce antioxidant, anti-inflammatory and other chemoprotective effects in a broad range of biomedical models. These perspectives have led to an extensive number of studies using various moringa extracts to evaluate its capacity to protect biological systems from oxidative stress and to explore whether it could be used to slow the onset of numerous age-related conditions and diseases. Moringa extracts have also been applied to prevent damage to plants from oxidative and saline stresses, following hormetic dose–response patterns. The present paper provides the first integrated and mechanistically based assessment showing that moringa extracts commonly induce hormetic dose responses and that many, perhaps most, of the beneficial effects of moringa are due to its capacity to act as an hormetic agent.
Critical examination of resilience and resistance in African American families: Adaptive capacities to navigate toxic oppressive upstream waters
Authors: Murry Velma McBride , Nyanamba Juliet M. , Hanebutt Rachel , Debreaux Marlena , Gastineau Kelsey A.B. , Goodwin Aijah K.B. , Narisetti Lipika
Published: September 2023

African American families navigate not only everyday stressors and adversities but also unique sociocultural stressors (e.g., “toxic upstream waters” like oppression). These adverse conditions are consequences of the historical vestiges of slavery and Jim Crow laws, often manifested as inequities in wealth, housing, wages, employment, access to healthcare, and quality education. Despite these challenges, African American families have developed resilience using strength-based adaptive coping strategies, to some extent, to filter these waters. To advance the field of resilience research, we focused on the following questions: (1) what constitutes positive responses to adversity?; (2) how is resilience defined conceptually and measured operationally?; (3) how has the field of resilience evolved?; (4) who defines what, when, and how responses are manifestations of resilience, instead of, for example, resistance? How can resistance, which at times leads to positive adaptations, be incorporated into the study of resilience?; and (5) are there case examples that demonstrate ways to address structural oppression and the pernicious effects of racism through system-level interventions, thereby changing environmental situations that sustain toxic waters requiring acts of resilience to survive and thrive? We end by exploring how a re-conceptualization of resilience requires a paradigm shift and new methodological approaches to understand ways in which preventive interventions move beyond focusing on families’ capacity to navigate oppression and target systems and structures that maintain these toxic waters.
Linked head injury and conduct problem symptom pathways from early childhood to adolescence and their associated risks: Evidence from the millennium cohort study
Authors: Carr Hannah R. , Brandt Valerie C. , Golm Dennis , Hall James E.
Published: September 2023

Conduct problems and head injuries increase the risk of delinquency and share a bidirectional association. However, how they link across development is unknown. The present study aimed to identify their linked developmental pathways and associated risk factors. Latent class analysis was modeled from Millennium Cohort Study data (n = 8,600) to identify linked pathways of conduct problem symptoms and head injuries. Head injuries were parent-reported from ages 3 to 14 and conduct problems from ages 3 to 17 using the Strengths and Difficulties Questionnaire (SDQ). Multinomial logistic regression then identified various risk factors associated with pathway membership. Four distinct pathways were identified. Most participants displayed low-level conduct problem symptoms and head injuries (n = 6,422; 74.7%). Three groups were characterized by clinically relevant levels of conduct problem symptoms and high-risk head injuries in childhood (n = 1,422; 16.5%), adolescence (n = 567; 6.6%), or persistent across development (n = 189; 2.2%). These clinically relevant pathways were associated with negative maternal parenting styles. These findings demonstrate how pathways of conduct problem symptoms are uniquely linked with distinct head injury pathways. Suggestions for general preventative intervention targets include early maternal negative parenting styles. Pathway-specific interventions are also required targeting cumulative risk at different ecological levels.
Cereal rye residue management tactics influence interrow and intrarow weed recruitment dynamics in field corn when planting green
Authors: Wallace John M. , Mazzone Tosh , Larson Zachary
Published: September 2023

Delaying cover crop termination until cash crop planting (i.e., planting green) is an emerging no-till practice. Improved management recommendations are needed for optimizing weed suppression benefits while minimizing other pest, fertility, and crop management risks when planting green in corn production systems. In a 2-yr field experiment, we evaluated the interaction between cereal rye residue management tactics (standing residue, roll-crimping, roll-crimping with row cleaners) and herbicide programs (1-pass preemergence [PRE], 2-pass postemergence [POST]) when planting green on weed recruitment spatial patterns and corn performance compared to standard termination (14 d preplant [DPP]) and ryelage harvest (14 DPP) practices. In a 2-yr on-farm experiment, we evaluated corn performance in response to the same residue management tactics. Cereal rye biomass production varied significantly across years in on-station experiments, with average (4.9 Mg ha−1) and anomalous (9.9 Mg ha−1) levels observed in 2020 and 2021, respectively. In 2020, planting green with an integrated roll-crimper/row cleaner system resulted in greater intrarow weed density compared with planting green into standing cereal rye. Interrow weed density was lower when roll-crimping was employed compared to early termination (14 DPP). Planting green into standing cereal rye resulted in greater mean corn height (V5 stage) compared to other treatments, but corn population and yield did not differ. In 2021, few differences in weed recruitment patterns were observed, but corn population and yield were significantly lower in planting green treatments compared to early termination. In both years, late-season weed biomass was lower in two-pass POST programs compared to one-pass PRE programs. On-farm trials showed that planting green into standing residue increases corn height and can reduce corn populations, which may lead to reduce yields. Our results suggest that management recommendations for optimizing herbicide application timing should consider intrarow and interrow weed recruitment dynamics associated with residue management tactics needed to optimize corn performance.
Using Template Matching to Detect Hidden Fluid Release Episodes Beneath Crater Lakes in Ruapehu, Copahue, and Kawah Ijen Volcanoes
Authors: Ardid A. , Dempsey D. , Caudron C. , Cronin S. J. , Miller C. A. , Melchor I. , Syahbana D. , Kennedy B.
Published: September 2023

Volcano crater lakes, while picturesque, can sometimes mask the occurrence of small eruptions or hydrothermal fluid release events. However, these seemingly hidden events hold a wealth of valuable information about the underlying volcanic conduit and may pose risks to those near the volcano’s summit. This study presents a novel method for identifying these hard‐to‐detect fluid release events by examining seismic data from Ruapehu volcano in New Zealand. We undertake a multi‐timescale template‐matching analysis that uses a newly discovered seismic eruption precursor, to identify patterns related to the rapid consolidation of hydrothermal seals, pressurization processes, and the subsequent release of hydrothermal fluids. As a result, we identified a potential instance of sudden fluid‐release events that were previously unnoticed due to the presence of the crater lake. Our findings support a conceptual model of cyclic pressure variation within the conduit beneath an active crater lake. This model involves the formation and disruption of seals, followed by depressurization through hydrothermal fluid release events. Fluid discharge recession recorded as seismic amplitude decay, provides information about the properties of the reservoir, conduit, and the fluid being discharged. We also applied this technique to Kawah‐Ijen (Indonesia) and Copahue (Chile‐Argentina), identifying multiple potential events at these volcanoes. These findings enhance our understanding of the conditions leading to explosive eruptions, including those that could breach the crater lake.
A High‐Resolution Shear Velocity Model of the Crust and Uppermost Mantle Beneath Westernmost Mediterranean Including Radial Anisotropy
Authors: Feng Lili , Diaz Jordi
Published: September 2023

Using seismic data from 1,186 stations deployed across the westernmost Mediterranean, we construct a high‐resolution 3‐D radially anisotropic model from a joint inversion of receiver functions and Rayleigh and Love wave dispersions. The Rayleigh and Love data are extracted from both ambient noise interferograms and earthquake waveforms, and a new three‐station ambient noise interferometry method is used to further improve the data coverage. The obtained crustal thickness map reproduces independently the Moho depth maps compiled from previous data, showing crustal roots beneath the Pyrenean‐Cantabrian range and the Gibraltar Arc and thicker crust beneath the Variscan Iberian Massif than in the area affected by Alpine orogenesis. TheVsvcrustal model outlines the Iberian Massif as a high shear wave velocity block and shows extremely low velocities in the Gulf of Cadiz and Gibraltar Arc. At mantle levels, a sharp boundary between the Aquitanean Basin and the Massif Central is imaged, with lowVsvbeneath the Massif Central probably reflecting a remaining signature of the magma. To the south of Iberia, the geometry of the Alboran slab is captured by the model, while beneath the Atlas Mountains, widespread lowVsvand positive radial anisotropy is observed, favoring the edge‐driven convection model explaining the lithospheric thinning. The most relevant contribution of this work is mapping, for the first time at this scale, the radial anisotropy anomalies at crustal level, with higher values observed in the Alpine Iberia, dominated by present‐day extensional tectonics.
Continuity of Global MODIS Terrestrial Primary Productivity Estimates in the VIIRS Era Using Model‐Data Fusion
Authors: Endsley K. Arthur , Zhao Maosheng , Kimball John S. , Devadiga Sadashiva
Published: September 2023

The NASA Terra and Aqua satellites have been successfully operating for over two decades, exceeding their original design life. However, the era of NASA's Earth Observing System may be coming to a close as early as 2023. Similarities between the Moderate Resolution Imaging Spectroradiometer (MODIS), aboard Aqua and Terra, and the Visible Infrared Imaging Radiometer Suite (VIIRS) sensors aboard the Suomi NPP, NOAA‐20 and NOAA‐21 satellites enable potential continuity of long‐term earth observational records in the VIIRS era. We conducted a comprehensive calibration and validation of the MODIS MOD17 product, which provided the first global, continuous, weekly estimates of ecosystem gross primary productivity (GPP) and annual estimates of net primary productivity (NPP). Using Bayesian model‐data fusion, we combined 18 years of tower fluxes with prior data on plant traits and hundreds of field measurements of NPP to benchmark MOD17 and to develop the first terrestrial productivity estimates from VIIRS. The updated mean global GPP (NPP) flux from the future MOD17 Collection 7 product and new VNP17 product for 2012–2018 is 127 ± 2.8 Pg C year−1 (58 ± 1.1 Pg C year−1), which compares well with independent top‐down and bottom‐up estimates. MOD17 and VNP17 depict upward productivity trends over recent decades, with 2000–2018 MOD17 GPP (NPP) rising by 0.47 (0.25) Pg C year−2 but slowing to 0.35–0.44 (0.11–0.13) Pg C year−2 over 2012–2021, with a greater reduction in the NPP growth rate. The new VIIRS VNP17 product has the potential to extend these estimates of global, terrestrial primary productivity beyond 2030.
Study on the Supercooling Characteristics of Freezing Soil Based On Nucleation Theory
Authors: Wang Chong , Li Kunyu , Lin Zhikun , Yang Zhijie , Cai Honghong , Lai Yuanming , Li Shuangyang
Published: September 2023

The clarification of freezing in a soil‐water system is critical for assessing the formation of a freezing zone and liquid water flow. The supercooling phenomenon of soil pore solutions has been found during the freezing process, but the mechanism remains poorly understood. In this study, we propose a free energy function of soil‐water systems based on the Classical Nucleation Theory. The analytical solution of the critical nucleation problem of saline soil‐water system is obtained by combining the initial freezing temperature model and Pitzer activity coefficients model in electrolyte solutions. Then, the freezing‐thawing experiments of saline soil with various salt contents were conducted for verifying the analytical solution. The derived boundary nucleation rate is the quantitative solution of the critical condition for the supercooling. The findings suggested that the theory results agreed well with the experiment results. For the salt‐free soil‐water system, the critical maximum radius of supercooling was 7.15 nm. We compared eight classical ice‐water interfacial tension models, and the “Reinhardt & Doye” and “DeMott & Rogers” models showed excellent performance when using the new free energy theoretical framework to predict the crystallization nucleation rate of soil‐water systems. A positive correlation between the boundary nucleation rate and soil‐water potential is detected. According to the influencing factors, the boundary nucleation rate of soil‐water system can be divided into three zones: salt nature control zone (R > 100 μm), salt‐pore mixed control zone (100 μm > R > 100 nm), and pore size control zone (R < 100 nm).
Effects of renal denervation on kidney function in patients with chronic kidney disease: a systematic review and meta-analysis
Authors: Mohammad Ahmed A. , Nawar Khaled , Binks Olivia , Abdulla Mohammed H.
Published: September 2023

The present study aims to evaluate the clinical outcomes following renal denervation (RDN) for hypertensive patients with chronic kidney disease (CKD). Prospective studies published between January 1, 2010 and November 15, 2022 where systematically identified for RDN outcomes on office and ambulatory blood pressure, estimated glomerular filtration rate (eGFR), creatinine and procedural characteristics from three online databases (Medline, PubMed, EMBASE). Random effects model to combine risk ratios and mean differences was used. Where possible, clinical outcomes were pooled and analyzed at 6, 12 and 24 months. Significance was set at p ≤ 0.05. 11 prospective trials, with a total of 226 patients with treatment resistant HTN receiving RDN met the inclusion criteria. Age ranged from 42.5 ± 13.8 to 66 ± 9. Main findings of this review included a reduction in systolic and diastolic office blood pressure at 6 [−19.8 (p < 0.00001)/−15.2 mm Hg (p < 0.00001)] and 12 months [−21.2 (p < 0.00001)/−9.86 mm Hg (p < 0.0005)] follow-up compared to baseline. This was also seen in systolic and diastolic 24-hour ambulatory blood pressure at 6 [−9.77 (p = 0.05)/−3.64 mm Hg (p = 0.09)] and 12 months [−13.42 (p = 0.0007)/−6.30 mm Hg (p = 0.001)] follow-up compared to baseline. The reduction in systolic and diastolic 24-hour ambulatory blood pressure was maintained to 24 months [(−16.30 (p = 0.0002)/−6.84 mm Hg (p = 0.0010)]. Analysis of kidney function through eGFR demonstrated non-significant results at 6 (+1.60 mL/min/1.73 m2, p = 0.55), 12 (+5.27 mL/min/1.73 m2, p = 0.17), and 24 months (+7.19 mL/min/1.73 m2, p = 0.36) suggesting an interruption in natural CKD progression. Similar results were seen in analysis of serum creatinine at 6 (+0.120 mg/dL, p = 0.41), 12 (+0.100 mg/dL, p = 0.70), and 24 months (+0.07 mg/dL, p = 0.88). Assessment of procedural complications deemed RDN in a CKD cohort to be safe with an overall complication rate of 4.86%. With the current advances in RDN and its utility in multiple chronic diseases beyond hypertension, the current study summarizes critical findings that further substantiate the literature regarding the potential of such an intervention to be incorporated as an effective treatment for resistant hypertension and CKD.
Electronic health records and stratified psychiatry: bridge to precision treatment?
Authors: Grzenda Adrienne , Widge Alik S.
Published: September 2023

The use of a stratified psychiatry approach that combines electronic health records (EHR) data with machine learning (ML) is one potentially fruitful path toward rapidly improving precision treatment in clinical practice. This strategy, however, requires confronting pervasive methodological flaws as well as deficiencies in transparency and reporting in the current conduct of ML-based studies for treatment prediction. EHR data shares many of the same data quality issues as other types of data used in ML prediction, plus some unique challenges. To fully leverage EHR data’s power for patient stratification, increased attention to data quality and collection of patient-reported outcome data is needed.
Molecular basis of RNA-binding and autoregulation by the cancer-associated splicing factor RBM39
Authors: Campagne Sébastien , Jutzi Daniel , Malard Florian , Matoga Maja , Romane Ksenija , Feldmuller Miki , Colombo Martino , Ruepp Marc-David , Allain Frédéric H-T.
Published: September 2023

Pharmacologic depletion of RNA-binding motif 39 (RBM39) using aryl sulfonamides represents a promising anti-cancer therapy but requires high levels of the adaptor protein DCAF15. Consequently, novel approaches to deplete RBM39 in an DCAF15-independent manner are required. Here, we uncover that RBM39 autoregulates via the inclusion of a poison exon into its own pre-mRNA and identify the cis-acting elements that govern this regulation. We also determine the NMR solution structures of RBM39’s tandem RNA recognition motifs (RRM1 and RRM2) bound to their respective RNA targets, revealing how RRM1 recognises RNA stem loops whereas RRM2 binds specifically to single-stranded N(G/U)NUUUG. Our results support a model where RRM2 selects the 3’-splice site of a poison exon and the RRM3 and RS domain stabilise the U2 snRNP at the branchpoint. Our work provides molecular insights into RBM39-dependent 3’-splice site selection and constitutes a solid basis to design alternative anti-cancer therapies.
Inherent spatiotemporal uncertainty of renewable power in China
Authors: Wang Jianxiao , Chen Liudong , Tan Zhenfei , Du Ershun , Liu Nian , Ma Jing , Sun Mingyang , Li Canbing , Song Jie , Lu Xi , Tan Chin-Woo , He Guannan
Published: September 2023

Solar and wind resources are vital for the sustainable energy transition. Although renewable potentials have been widely assessed in existing literature, few studies have examined the statistical characteristics of the inherent renewable uncertainties arising from natural randomness, which is inevitable in stochastic-aware research and applications. Here we develop a rule-of-thumb statistical learning model for wind and solar power prediction and generate a year-long dataset of hourly prediction errors of 30 provinces in China. We reveal diversified spatiotemporal distribution patterns of prediction errors, indicating that over 60% of wind prediction errors and 50% of solar prediction errors arise from scenarios with high utilization rates. The first-order difference and peak ratio of generation series are two primary indicators explaining the uncertainty distribution. Additionally, we analyze the seasonal distributions of the provincial prediction errors that reveal a consistent law in China. Finally, policies including incentive improvements and interprovincial scheduling are suggested.
Suppression of hollow droplet rebound on super-repellent surfaces
Authors: Zhou Ying , Zhang Chenguang , Zhao Wenchang , Wang Shiyu , Zhu Pingan
Published: September 2023

Droplet rebound is ubiquitous on super-repellent surfaces. Conversion between kinetic and surface energies suggests that rebound suppression is unachievable due to negligible energy dissipation. Here, we present an effective approach to suppressing rebounds by incorporating bubbles into droplets, even in super-repellent states. This suppression arises from the counteractive capillary effects within bubble-encapsulated hollow droplets. The capillary flows induced by the deformed inner-bubble surface counterbalance those driven by the outer-droplet surface, resulting in a reduction of the effective take-off momentum. We propose a double-spring system with reduced effective elasticity for hollow droplets, wherein the competing springs offer distinct behavior from the classical single-spring model employed for single-phase droplets. Through experimental, analytical, and numerical validations, we establish a comprehensive and unified understanding of droplet rebound, by which the behavior of single-phase droplets represents the exceptional case of zero bubble volume and can be encompassed within this overarching framework.
Manipulations of multi-frequency waves and signals via multi-partition asynchronous space-time-coding digital metasurface
Authors: Wang Si Ran , Dai Jun Yan , Zhou Qun Yan , Ke Jun Chen , Cheng Qiang , Cui Tie Jun
Published: September 2023

Manipulations of multiple carrier frequencies are especially important in a variety of fields like radar detection and wireless communications. In conventional radio-frequency architecture, the multi-frequency control is implemented by microwave circuits, which are hard to integrate with antenna apertures, thus bringing the problems of expensive system and high power consumption. Previous studies demonstrate the possibility to jointly control the multiple harmonics using space-time-coding digital metasurface, but suffer from the drawback of inherent harmonic entanglement. To overcome the difficulties, we propose a multi-partition asynchronous space-time-coding digital metasurface (ASTCM) to generate and manipulate multiple frequencies with more flexibility. We further establish an ASTCM-based transmitter to realize wireless communications with frequency-division multiplexing, where the metasurface is responsible for carrier-wave generations and signal modulations. The direct multi-frequency controls with ASTCM provides a new avenue to simplify the traditional wireless systems with reduced costs and low power consumption.
Evolution of phenotypic disparity in the plant kingdom
Authors: Clark James W. , Hetherington Alexander J. , Morris Jennifer L. , Pressel Silvia , Duckett Jeffrey G. , Puttick Mark N. , Schneider Harald , Kenrick Paul , Wellman Charles H. , Donoghue Philip C. J.
Published: September 2023

The plant kingdom exhibits diverse bodyplans, from single-celled algae to complex multicellular land plants, but it is unclear how this phenotypic disparity was achieved. Here we show that the living divisions comprise discrete clusters within morphospace, separated largely by reproductive innovations, the extinction of evolutionary intermediates and lineage-specific evolution. Phenotypic complexity correlates not with disparity but with ploidy history, reflecting the role of genome duplication in plant macroevolution. Overall, the plant kingdom exhibits a pattern of episodically increasing disparity throughout its evolutionary history that mirrors the evolutionary floras and reflects ecological expansion facilitated by reproductive innovations. This pattern also parallels that seen in the animal and fungal kingdoms, suggesting a general pattern for the evolution of multicellular bodyplans.
Spatial multimodal analysis of transcriptomes and metabolomes in tissues
Authors: Vicari Marco , Mirzazadeh Reza , Nilsson Anna , Shariatgorji Reza , Bjärterot Patrik , Larsson Ludvig , Lee Hower , Nilsson Mats , Foyer Julia , Ekvall Markus , Czarnewski Paulo , Zhang Xiaoqun , Svenningsson Per , Käll Lukas , Andrén Per E. , Lundeberg Joakim
Published: September 2023

We present a spatial omics approach that combines histology, mass spectrometry imaging and spatial transcriptomics to facilitate precise measurements of mRNA transcripts and low-molecular-weight metabolites across tissue regions. The workflow is compatible with commercially available Visium glass slides. We demonstrate the potential of our method using mouse and human brain samples in the context of dopamine and Parkinson’s disease.
Plant traits and associated data from a warming experiment, a seabird colony, and along elevation in Svalbard
Authors: Vandvik Vigdis , Halbritter Aud H. , Althuizen Inge H. J. , Christiansen Casper T. , Henn Jonathan J. , Jónsdóttir Ingibjörg Svala , Klanderud Kari , Macias-Fauria Marc , Malhi Yadvinder , Maitner Brian Salvin , Michaletz Sean , Roos Ruben E. , Telford Richard J. , Bass Polly , Björnsdóttir Katrín , Bustamante Lucely Lucero Vilca , Chmurzynski Adam , Chen Shuli , Haugum Siri Vatsø , Kemppinen Julia , Lepley Kai , Li Yaoqi , Linabury Mary , Matos Ilaíne Silveira , Neto-Bradley Barbara M. , Ng Molly , Niittynen Pekka , Östman Silje , Pánková Karolína , Roth Nina , Castorena Matiss , Spiegel Marcus , Thomson Eleanor , Vågenes Alexander Sæle , Enquist Brian J.
Published: September 2023

The Arctic is warming at a rate four times the global average, while also being exposed to other global environmental changes, resulting in widespread vegetation and ecosystem change. Integrating functional trait-based approaches with multi-level vegetation, ecosystem, and landscape data enables a holistic understanding of the drivers and consequences of these changes. In two High Arctic study systems near Longyearbyen, Svalbard, a 20-year ITEX warming experiment and elevational gradients with and without nutrient input from nesting seabirds, we collected data on vegetation composition and structure, plant functional traits, ecosystem fluxes, multispectral remote sensing, and microclimate. The dataset contains 1,962 plant records and 16,160 trait measurements from 34 vascular plant taxa, for 9 of which these are the first published trait data. By integrating these comprehensive data, we bridge knowledge gaps and expand trait data coverage, including on intraspecific trait variation. These data can offer insights into ecosystem functioning and provide baselines to assess climate and environmental change impacts. Such knowledge is crucial for effective conservation and management in these vulnerable regions.
2DeteCT - A large 2D expandable, trainable, experimental Computed Tomography dataset for machine learning
Authors: Kiss Maximilian B. , Coban Sophia B. , Batenburg K. Joost , van Leeuwen Tristan , Lucka Felix
Published: September 2023

Recent research in computational imaging largely focuses on developing machine learning (ML) techniques for image reconstruction, which requires large-scale training datasets consisting of measurement data and ground-truth images. However, suitable experimental datasets for X-ray Computed Tomography (CT) are scarce, and methods are often developed and evaluated only on simulated data. We fill this gap by providing the community with a versatile, open 2D fan-beam CT dataset suitable for developing ML techniques for a range of image reconstruction tasks. To acquire it, we designed a sophisticated, semi-automatic scan procedure that utilizes a highly-flexible laboratory X-ray CT setup. A diverse mix of samples with high natural variability in shape and density was scanned slice-by-slice (5,000 slices in total) with high angular and spatial resolution and three different beam characteristics: A high-fidelity, a low-dose and a beam-hardening-inflicted mode. In addition, 750 out-of-distribution slices were scanned with sample and beam variations to accommodate robustness and segmentation tasks. We provide raw projection data, reference reconstructions and segmentations based on an open-source data processing pipeline.
Effects of sowing date on photosynthetic characteristics, chlorophyll fluorescence and yield of different Echium plantagineum L. cultivars
Authors: Wang Wu , Wei Longxue , Li Hongming , Xu Huifeng , Xu Zhen , Yan Chengming , Wu Ying , Ji Shengzhen , Wang Tao
Published: September 2023

The seed oil of Echium plantagineum L. is rich in unsaturated fatty acids. With the gradual development of the value of echium oil in food, medical care and cosmetics, the corresponding market demand has also increased. The selection of suitable cultivars and the increase of yield per unit area has also become one of the main objectives of current breeding and cultivation of E. plantagineum. To effectively use the local photothermal resources, to improve the use of light energy by E. plantagineum, and to enhance the growth and yield of E. plantagineum. E. plantagineum cultivars Blue Bedder and Mixed Bedding were used as research subjects to study the effects of different sowing dates (1 May, 8 May, 15 May, 22 May and 29 May) on the photosynthetic characteristics and yield of E. plantagineum. Under the same cultivar conditions, with the delay in sowing date, the leaf chlorophyll content (SPAD), photosynthetic rate (Pn), transpiration rate (Tr), stomatal limitation value (Ls), photochemical quenching (qP), electron transfer rate (ETR), actual photochemical efficiency (ΦpsII) and yield of Blue Bedder decreased and reached a maximum at T1, while the SPAD, Pn, Tr, water use efficiency (WUE), Ls, initial fluorescence (Fo), maximum fluorescence (Fm), qP, ETR, ΦpsII and yield of Mixed Bedding reached the maximum at T4. Blue Bedder should be sown early at T1 and Mixed Bedding late at T4 during planting, which will help to improve the photosynthetic characteristics and grain yield of E. plantagineum.
Vibrational-mechanical properties of the highly-mismatched Cd1−xBexTe semiconductor alloy: experiment and ab initio calculations
Authors: Elmahjoubi A. , Shoker M. B. , Pagès O. , Torres V. J. B. , Polian A. , Postnikov A. V. , Bellin C. , Béneut K. , Gardiennet C. , Kervern G. , En Naciri A. , Broch L. , Hajj Hussein R. , Itié J.-P. , Nataf L. , Ravy S. , Franchetti P. , Diliberto S. , Michel S. , Abouais A. , Strzałkowski K.
Published: September 2023

The emerging CdTe–BeTe semiconductor alloy that exhibits a dramatic mismatch in bond covalency and bond stiffness clarifying its vibrational-mechanical properties is used as a benchmark to test the limits of the percolation model (PM) worked out to explain the complex Raman spectra of the related but less contrasted Zn1−xBex-chalcogenides. The test is done by way of experiment ($$x\le 0.11$$

x
≤
0.11

), combining Raman scattering with X-ray diffraction at high pressure, and ab initio calculations ($$x$$
x
 ~ 0–0.5; $$x$$
x
~1). The (macroscopic) bulk modulus $${B}_{0}$$

B
0

drops below the CdTe value on minor Be incorporation, at variance with a linear $${B}_{0}$$

B
0

versus $$x$$
x
increase predicted ab initio, thus hinting at large anharmonic effects in the real crystal. Yet, no anomaly occurs at the (microscopic) bond scale as the regular bimodal PM-type Raman signal predicted ab initio for Be–Te in minority ($$x$$
x
~0, 0.5) is barely detected experimentally. At large Be content ($$x$$
x
~1), the same bimodal signal relaxes all the way down to inversion, an unprecedented case. However, specific pressure dependencies of the regular ($$x$$
x
~0, 0.5) and inverted ($$x$$
x
~1) Be–Te Raman doublets are in line with the predictions of the PM. Hence, the PM applies as such to Cd1−xBexTe without further refinement, albeit in a “relaxed” form. This enhances the model’s validity as a generic descriptor of phonons in alloys.
Perceived stress of mothers and fathers on two NICUs before and during the SARS-CoV-2 pandemic
Authors: Deindl Philipp , Witting Andrea , Dür Mona , Berger Angelika , Klebermass-Schrehof Katrin , Singer Dominique , Giordano Vito , Fuiko Renate
Published: September 2023

Parents of very low birth weight (VLBW) infants in a neonatal intensive care unit experienced additional stress during the SARS-CoV-2 pandemic due to the related restrictions in hospital visiting policies. Our study aimed to compare parents' burdens before and during the pandemic. This survey included 121 parents of 76 VLBW infants in two European Level IV perinatal centers before and during the pandemic. We performed standardized parent questionnaires with mothers and fathers separately to evaluate their emotional stress and well-being. The pandemic worsened the emotional well-being of parents of VLBW infants, particularly of mothers. During the pandemic, mothers reported significantly higher state anxiety levels (48.9 vs. 42.9, p = 0.026) and hampered bonding with the child (6.3 vs. 5.2, 0 = 0.003) than before. In addition, mothers felt more personally restricted than fathers (6.1 vs. 5.2, p = 0.003). Fathers experienced lower levels of stress than mothers; they were equally burdened before and during the pandemic. Restrictions in visiting policies for families of VLBW infants during the SARS-CoV-2 pandemic have a significant negative impact on parental stress and should therefore be applied cautiously.