bluuebunny/crossref_metadata_2025 huggingface dataset:
Temperature and Ambient Band Structure Changes in SnO2 for the Optimization of Hydrogen Response
Authors: Filippatos Petros-Panagis , Soultati Anastasia , Kelaidis Nikolaos , Davazoglou Dimitris , Vasilopoulou Maria , Drivas Charalampos , Kennou Stella , Chroneos Alexander
Published: February 2023

Tin dioxide (SnO2) is one of the most used materials for sensing applications operating at high temperatures. Commonly, “undoped SnO2” is made by precursors containing elements that can have a deleterious impact on the operation of SnO2 sensors. Here, we employ experimental and theoretical methods to investigate the structural properties and electronic structure of the rutile bulk and surface SnO2, focusing on unintentional doping due to precursors. Unintentional doping from precursors as well as intrinsic doping can play an important role not only on the performance of gas sensors, but also on the properties of SnO2 as a whole. The theoretical calculations were performed using density functional theory (DFT) with hybrid functionals. With DFT we examine the changes in the electronic properties of SnO2 due to intrinsic and unintentional defects and we then discuss how these changes affect the response of a SnO2-based gas sensor. From an experimental point of view, we synthesized low-cost SnO2 thin films via sol–gel and spin-coating processes. To further enhance the performance of SnO2, we coated the surface with a small amount of platinum (Pt). The crystalline structure of the films was analyzed using x-ray diffraction (XRD) and scanning electron microscopy (SEM), while for the determination of the elements contained in the sample, X-ray photoelectron spectroscopy (XPS) measurements were performed. Furthermore, we investigated the effect of temperature on the band structure of SnO2 in air, in a vacuum and in nitrogen and hydrogen chemical environments. To optimize the response, we used current–voltage characterization in varying environments. The aim is to associate the response of SnO2 to various environments with the changes in the band structure of the material in order to gain a better understanding of the response mechanism of metal oxides in different pressure and temperature environments. We found that the resistance of the semiconductor decreases with temperature, while it increases with increasing pressure. Furthermore, the activation energy is highly affected by the environment to which the thin film is exposed, which means that the thin film could respond with lower energy when exposed to an environment different from the air.
Pressure-Induced Reversible Local Structural Disorder in Superconducting AuAgTe4
Authors: Zamyatin Dmitry A. , Pankrushina Elizaveta A. , Streltsov Sergey V. , Ponosov Yuri S.
Published: February 2023

Here, we report results of the investigation of the lattice dynamics of the sylvanite mineral AuAgTe4 in a wide temperature and pressure range by Raman spectroscopy, together with the first-principle calculations. At ambient pressure, the experimental spectrum agrees well with the calculation data. The temperature behavior of the phonon self-energies (frequencies and linewidths) are described by an anharmonic mechanism and imply negligible contributions of electron–phonon interaction at low temperatures. A structural phase transition was recorded in the pressure range of 4–6 GPa, which is in accordance with theoretical predictions. At higher pressures, evidence of local structural disorder was found that made it possible to experimentally observe the spectrum of the density of vibrational states of AuAgTe4, which becomes superconducting under pressure.
Au(III) Cyclometallated Compounds with 2-Arylpyridines and Their Derivatives or Analogues: 34 Years (1989–2022) of NMR and Single Crystal X-ray Studies
Authors: Pazderski Leszek , Abramov Pavel A.
Published: February 2023

A review paper on Au(III) cyclometallated compounds with 2-arylpyridines (2-phenylpyridine, 2-benzylpyridine, 2-benzoylpyridine, 2-phenoxypyridine, 2-phenylsulfanylpyridine, 2-anilinopyridine, 2-(naphth-2-yl)pyridine, 2-(9,9-dialkylfluoren-2-yl)pyridines, 2-(dibenzofuran-4-yl)pyridine, and their derivatives) and their analogues (2-arylquinolines, 1- and 3-arylisoquinolines, 7,8-benzoquinoline), with 113 references. A total of 554 species, containing κ2-N(1),C(6′)*-Au(III), or analogous moiety (i.e., chelated by nitrogen of the pyridine-like ring and the deprotonated ortho- carbon of the phenyl-like ring) and, thus, possessing a character intermediate between metal complexes and organometallics, studied in the years 1989–2022 by NMR spectroscopy and/or single crystal X-ray diffraction (207 X-ray structures), are described. The compounds for which biological or catalytic activity and the luminescence properties were studied are also quoted.
Does ICT Usage Have a Positive or Negative Effect on Taiwanese Older Adults’ Emotional Experiences? The Moderating Role of Basic Psychological Needs Satisfaction
Authors: Liu Chih-Chi , Wang Ya-Ling
Published: February 2023

While some studies have found that older adults’ use of information and communications technology (ICT) contributes to their positive emotions, others have not. According to previous research, basic psychological needs satisfaction may help us explore the relationships between older adults’ ICT usage and their emotional experience. This study aimed to investigate the moderation effect of older adults’ basic psychological needs satisfaction on the relationship between ICT usage and emotional experience using the experience sampling method via the communication application, Line. At the first phase of the study, we surveyed each participant’s age, gender and satisfaction with basic psychological needs, and afterward, each participant needed to complete their current situation each day throughout the 10-day period. A total of 788 daily experiences of 32 participants (Mage = 63.13; SDage = 5.97, ranging from 52 to 75; 81% women) were collected, and hierarchical linear modeling (HLM) was conducted. Results revealed that ICT usage generally enhanced older adults’ positive emotional experience. Those with satisfied competence needs had stable and positive emotional experiences with or without using ICT, while those without could further promote their positive emotional experience by using ICT. Those with satisfied relatedness needs had more positive emotional experiences when using ICT, while those without had similar emotional experiences with or without ICT.
The Delimitation of Geographic Distributions of Gobius bucchichi and Gobius incognitus (Teleostei: Gobiidae)
Authors: Kovačić Marcelo , Renoult Julien P. , Pillon Roberto , Bilecenoglu Murat , Tiralongo Francesco , Bogorodsky Sergey V. , Engin Semih , Kovtun Oleg , Louisy Patrick , Patzner Robert A. , Rothman Shevy Bat-Sheva , Soldo Alen , Yokes Mehmet Baki
Published: February 2023

After the description of Gobius incognitus Kovačić & Šanda, 2016, all previous knowledge about the geographic distribution of Gobius bucchichi Steindachner, 1870, as well as its ecology and biology, became obsolete, since it represented the data from the mixture of two species. The known geographic distribution of G. bucchichi and G. incognitus is revisited by validating previously published records, but also and foremost by integrating many new photographic records posted by anglers and divers on social media and on citizen science databases. The present research uses only positively identified records with exact data on locality, coordinates and date of collecting. A total of 1024 confirmed records were collected and retained for inferring distribution maps: 805 records of G. incognitus and 219 records of G. bucchichi. Gobius incognitus is a widespread Mediterranean Sea species with limited presence in the Lusitanian province of the Eastern Atlantic Ocean. It is absent from the Sea of Marmara and the Black Sea. Gobius bucchichi is recorded only in the eastern half of the Mediterranean Sea, from the Adriatic to the Aegean Sea, and in the Black Sea and Sea of Marmara.
Coupled Translational–Rotational Stability Analysis of a Submersible Ocean Current Converter Platform Mooring System under Typhoon Wave
Authors: Lin Shueei-Muh , Utama Didi Widya , Liauh Chihng-Tsung
Published: February 2023

This study proposes a mathematical model for the coupled translational–rotational motions of a mooring system for an ocean energy converter working under a typhoon wave impact. The ocean energy convertor comprises two turbine generators and an integration structure. The configuration of the turbine blade and the floating platform is designed. The two turbine blades rotate reversely at the same rotating speed for rotational balance. If the current velocity is 1.6 m/s and the tip speed ratio is 3.5, the power generation is approximately 400 kW. In the translational and rotational motions of elements under ocean velocity, the hydrodynamic parameters in the fluid–structure interaction are studied. Initially, the hydrodynamic forces and moments on the converter and the platform are calculated and further utilized in obtaining the hydrodynamic damping and stiffness parameters. The 18 degrees of freedom governing equations of the mooring system are derived. The solution method of the governing equations is utilized to determine the component’s motion and the ropes’ dynamic tensions. In the mooring system, the converter is mounted under a water surface at some safe depth so that it can remain undamaged and stably generate electricity under typhoon wave impact and water pressure. It is theoretically verified that the translational and angular displacements of the converter can be kept small under the large wave impact. In other words, the water pressure on the converter cannot exceed the predicted value. The relative flow velocity of the convertor to the current is kept fixed such that the power efficiency of convertor can be maintained as high. In addition, the dynamic tension of the rope is far less than its breaking strength.
Optimal Assimilation Number of Phytoplankton in the Siberian Seas: Spatiotemporal Variability, Environmental Control and Estimation Using a Region-Specific Model
Authors: Demidov Andrey B. , Belevich Tatiana A. , Sheberstov Sergey V.
Published: February 2023

The maximal value of the chlorophyll-specific carbon fixation rate in the water column or the optimal assimilation number (Pbopt) is an important parameter used to estimate water column integrated primary production (IPP) using models and satellite-derived data. The spatiotemporal variability in the Pbopt of the total and size-fractionated phytoplankton in the Siberian Seas (SSs) and its links with environmental factors were studied based on long-term (1993–2020) field and satellite-derived (MODIS-Aqua) observations. The average value of Pbopt in the SSs was equal to 1.38 ± 0.76 mgC (mg Chl a)–1 h–1. The monthly average values of Pbopt decreased during the growing season from 1.95 mgC (mg Chl a)–1 h–1 in July to 0.64 mgC (mg Chl a)–1 h–1 in October. The average value of Pbopt for small (<3 μm) phytoplankton 1.6-fold exceeded that for large (>3 μm) phytoplankton. The values of Pbopt depend mainly on incident photosynthetically available radiation (PAR). Based on the relationship between Pbopt and PAR, the empirical region-specific algorithm (E0reg) was developed. The E0reg algorithm performed better than commonly used temperature-based models. The application of E0reg for the calculation of Pbopt will make it possible to more precisely estimate IPP in the SSs.
What Is New in Pulmonary Mucormycosis?
Authors: Danion François , Coste Anne , Le Hyaric Coralie , Melenotte Clea , Lamoth Frederic , Calandra Thierry , Garcia-Hermoso Dea , Aimanianda Vishukumar , Lanternier Fanny , Lortholary Olivier
Published: February 2023

Mucormycosis is a rare but life-threatening fungal infection due to molds of the order Mucorales. The incidence has been increasing over recent decades. Worldwide, pulmonary mucormycosis (PM) presents in the lungs, which are the third main location for the infection after the rhino-orbito-cerebral (ROC) areas and the skin. The main risk factors for PM include hematological malignancies and solid organ transplantation, whereas ROC infections classically are classically favored by diabetes mellitus. The differences between the ROC and pulmonary locations are possibly explained by the activation of different mammalian receptors—GRP78 in nasal epithelial cells and integrin β1 in alveolar epithelial cells—in response to Mucorales. Alveolar macrophages and neutrophils play a key role in the host defense against Mucorales. The diagnosis of PM relies on CT scans, cultures, PCR tests, and histology. The reversed halo sign is an early, but very suggestive, sign of PM in neutropenic patients. Recently, the serum PCR test showed a very encouraging performance for the diagnosis and follow-up of mucormycosis. Liposomal amphotericin B is the drug of choice for first-line therapy, together with correction of underlying disease and surgery when feasible. After a stable or partial response, the step-down treatment includes oral isavuconazole or posaconazole delayed release tablets until a complete response is achieved. Secondary prophylaxis should be discussed when there is any risk of relapse, such as the persistence of neutropenia or the prolonged use of high-dose immunosuppressive therapy. Despite these novelties, the mortality rate from PM remains higher than 50%. Therefore, future research must define the place for combination therapy and adjunctive treatments, while the development of new treatments is necessary.
Improvement of Laccase Production by Thielavia terrestris Co3Bag1. Enhancing the Bio-Catalytic Performance of the Native Thermophilic TtLacA via Immobilization in Copper Alginate Gel Beads
Authors: Gutiérrez-Antón Marina , Santiago-Hernández Alejandro , Rodríguez-Mendoza Johan , Cano-Ramírez Claudia , Bustos-Jaimes Ismael , Aguilar-Osorio Guillermo , Campos Jorge E. , Hidalgo-Lara María Eugenia
Published: February 2023

A 32-fold increase in laccase activity production by the thermophilic biomass-degrading fungus T. terrestris Co3Bag1 was achieved when the microorganism was grown on a modified medium containing fructose, sodium nitrate, and copper. A 70 kDa laccase (TtLacA), produced under the above conditions, was purified, immobilized in copper alginate gel beads, and characterized. TtLacA, both free and immobilized enzymes, exhibited optimal activity at pH 3.0, at a temperature of 65 and 70 °C, respectively, although both displayed 70% of activity from 40 to 70 °C. Free and immobilized enzymes retained at least 80% of relative activity in the pH range from 3 to 4.6. Immobilized TtLacA manifested a 2.3-fold higher thermal stability than the free form of the enzyme at 60 and 70 °C. Immobilized TtLacA retained 95% initial activity for six consecutive reuse cycles at 60 °C, and also retained 86% of initial activity after 12 days of storage at 4 °C. Based on the biochemical features, thermophilic TtLacA may be an efficient enzyme for dye decolorization and other industrial applications at high temperatures or acidic conditions. This work represents the first report about the immobilization and biochemical characterization of a thermophilic laccase from a member of the genus Thielavia.
Research Trend, Logical Structure and Outlook on Complex Economic Game
Authors: Wu Fang , Ma Junhai
Published: February 2023

Diseases, natural disasters, and other emergencies force the economy and management system to confront nonlinear and random changes. In recent years, complexity science has attracted much attention. Complex economics believes that economic models are dynamic, stochastic, and unpredictable, and that equilibrium and stability are temporary. It is changing traditional economic theory. Based on complexity theory, bibliometric theory, nonlinear theory, and game theory, combined with knowledge graph methods, the article analyzed 200 papers from the Web of Science, covering the period 1998–2022. This research presents the research structure and theoretical evolution of complex economic games through visualization techniques. The clusters of keywords and the logical relationships between them are discussed. Then, the analysis of hot keywords and co-occurrence keywords is carried out. Finally, future research directions for complex economic games are given: (1) the market complexity that comes with intelligent expectations, (2) complex characteristics of the data trading market, and (3) complex risk control for emergencies. The innovation lies in the use of data analysis software combined with manual knowledge to overcome the shortcomings of inflexible software analysis, as well as weak manual storage and computation. This research builds a theoretical foundation for grasping the research direction and selecting advanced topics.
Modification of Learning Ratio and Drop-Out for Stochastic Gradient Descendant Algorithm
Authors: Teso-Fz-Betoño Adrian , Zulueta Ekaitz , Cabezas-Olivenza Mireya , Fernandez-Gamiz Unai , Botana-M-Ibarreta Carlos
Published: February 2023

The stochastic gradient descendant algorithm is one of the most popular neural network training algorithms. Many authors have contributed to modifying or adapting its shape and parametrizations in order to improve its performance. In this paper, the authors propose two modifications on this algorithm that can result in a better performance without increasing significantly the computational and time resources needed. The first one is a dynamic learning ratio depending on the network layer where it is applied, and the second one is a dynamic drop-out that decreases through the epochs of training. These techniques have been tested against different benchmark function to see their effect on the learning process. The obtained results show that the application of these techniques improves the performance of the learning of the neural network, especially when they are used together.
A Tumor MRI Image Segmentation Framework Based on Class-Correlation Pattern Aggregation in Medical Decision-Making System
Authors: Wei Hui , Lv Baolong , Liu Feng , Tang Haojun , Gou Fangfang , Wu Jia
Published: February 2023

Medical image analysis methods have been applied to clinical scenarios of tumor diagnosis and treatment. Many studies have attempted to optimize the effectiveness of tumor MRI image segmentation by deep learning, but they do not consider the optimization of local details and the interaction of global semantic information. Second, although medical image pattern recognition can learn representative semantic features, it is challenging to ignore useless features in order to learn generalizable embeddings. Thus, a tumor-assisted segmentation method is proposed to detect tumor lesion regions and boundaries with complex shapes. Specifically, we introduce a denoising convolutional autoencoder (DCAE) for MRI image noise reduction. Furthermore, we design a novel tumor MRI image segmentation framework (NFSR-U-Net) based on class-correlation pattern aggregation, which first aggregates class-correlation patterns in MRI images to form a class-correlational representation. Then the relationship of similar class features is identified to closely correlate the dense representations of local features for classification, which is conducive to identifying image data with high heterogeneity. Meanwhile, the model uses a spatial attention mechanism and residual structure to extract effective information of the spatial dimension and enhance statistical information in MRI images, which bridges the semantic gap in skip connections. In the study, over 4000 MRI images from the Monash University Research Center for Artificial Intelligence are analyzed. The results show that the method achieves segmentation accuracy of up to 96% for tumor MRI images with low resource consumption.
Multi-Stage Production and Process Outsourcing in Automobile-Part Supply Chain Considering a Carbon Tax Strategy Using Sequential Quadratic Optimization Technique
Authors: Alkahtani Mohammed , Hidri Lofti , Mrad Mehdi
Published: February 2023

This research focused on modeling and optimizing production and outsourcing operations in a supply chain (SC) while considering environmental challenges. The proposed mathematical model was nonlinear, implying outsourcing, and took into account reworking and carbon tax. It was solved using sequential quadratic programming (SQP) to achieve best solutions. Transportation significantly impacts carbon emission, which, herein, was considered the total cost of the SC. The model was tested using data from the automobile part industry, and sensitivity analyses were performed to understand the impacts of individual parameters on the total cost of the supply chain. The results could provide valuable insights for managers seeking to optimize production and outsourcing for a resilient supply chain.
Angiotensin-Converting Enzyme 2 Expression and Severity of SARS-CoV-2 Infection
Authors: Alabsi Sarah , Dhole Atharva , Hozayen Sameh , Chapman Scott A.
Published: February 2023

Angiotensin-converting enzyme 2 (ACE2), first discovered in 2000, serves as an important counterregulatory enzyme to the angiotensin II-mediated vasoconstrictive, pro-inflammatory, and pro-fibrotic actions of the renin–angiotensin system (RAS). Conversion of angiotensin II to the peptide angiotensin 1–7 (ANG 1–7) exerts protective vasodilatory, anti-inflammatory, and anti-fibrotic actions through interaction with the MasR receptor. There are many important considerations when noting the role of ACE2 in the pathogenesis and sequelae of COVID-19 infection. ACE2, in the role of COVID-19 infection, was recognized early in 2020 at the beginning of the pandemic as a cell membrane-bound and soluble binding site for the viral spike protein facilitating entering into tissue cells expressing ACE2, such as the lungs, heart, gut, and kidneys. Mechanisms exist that alter the magnitude of circulating and membrane-bound ACE2 (e.g., SARS-CoV-2 infection, viral variants, patient characteristics, chronic disease states, and the degree of cell surface expression of ACE2) and the influence these mechanisms have on the severity of disease and associated complications (e.g., respiratory failure, systemic inflammatory response syndrome, acute myocarditis, acute kidney injury). Several medications alter the ACE2 receptor expression, but whether these medications can influence the course of the disease and improve outcomes is unclear. In this review, we will discuss what is known about the interrelation of SARS-CoV-2, ACE2 and the factors that may contribute to the variability of its expression and potential contributors to the severity of COVID-19 infection.
Leukocyte Response to Campylobacter Intra-Abdominal Infection in One Day Old Leghorn Chickens
Authors: Genovese Kenneth J. , He Haiqi , Swaggerty Christina L. , Byrd J. Allen , Kogut Michael H.
Published: February 2023

Using a previously characterized and described abdominal model to define the avian immune response to Salmonella intra-abdominal challenge in chickens, we have adapted this technique for the study of chickens’ immune response to a Campylobacter intra-abdominal challenge. The intra-abdominal Campylobacter infection model facilitates the characterization of peripheral blood leukocyte dynamics and abdominal cell infiltrates. Day-of-hatch Leghorn chickens were injected intra-abdominally (IA) with Campylobacter jejuni [(CJ)1 × 108 colony-forming units (CFUs)]. Changes in peripheral blood leukocyte numbers and abdominal cell infiltrates were monitored at 0, 4, 8, and 24 h post-injection. Peripheral blood leukocyte numbers were also determined for 2 h post-injection. For mortality studies, birds were injected intra-abdominally with 1 × 108 CFUs CJ and mortalities were recorded for 72 h post-injection. In the peripheral blood of CJ-injected chicks, total white blood cell (WBC) numbers began increasing by 2 h post-injection, peaking at 4 h post-injection with the predominant cell type being polymorphonuclear leukocytes (heterophils). Total WBCs declined after 8 h and this decline continued at 24 h, with total WBC numbers approaching control values. The injection of CJ into the abdominal cavity caused a rapid rise in abdominal cell infiltrates with the predominant infiltrating leukocytes being heterophils. Peak abdominal heterophil infiltrates were observed at 8 h post-injection, declining only slightly by 24 h post-injection. Mortality in the CJ challenge groups reached 37%. Mortality in the Salmonella enteritidis positive control groups were greater than 50%. The data suggest that Campylobacter infection does stimulate the innate immune response in chickens when administered IA, however, the immune response and infection is not characterized with the high levels of mortality observed with a Salmonella infection. These data provide a basis for a more definitive characterization of chickens’ immune response to Campylobacter and a model to evaluate intervention strategies to prevent the infection and colonization of poultry.
Electro-Oxidative C3-Selenylation of Pyrido[1,2-a]pyrimidin-4-ones
Authors: Shi Jianwei , Wang Zhichuan , Teng Xiaoxu , Zhang Bing , Sun Kai , Wang Xin
Published: February 2023

In this work, we achieved a C3-selenylation of pyrido[1,2-a]pyrimidin-4-ones using an electrochemically driven external oxidant-free strategy. Various structurally diverse seleno-substituted N-heterocycles were obtained in moderate to excellent yields. Through radical trapping experiments, GC-MS analysis and cyclic voltammetry study, a plausible mechanism for this selenylation was proposed.
Comparison of the Determination of Some Antihypertensive Drugs in Clinical Human Plasma Samples by Solvent Front Position Extraction and Precipitation Modes
Authors: Jaglińska Kamila , Polak Beata , Klimek-Turek Anna , Fornal Emilia , Stachniuk Anna , Trzpil Alicja , Błaszczyk Robert , Wysokiński Andrzej
Published: February 2023

The determination of the selected antihypertensive drugs in human plasma samples with the novel solvent front position extraction (SFPE) technique is presented. The SFPE procedure combined with LC-MS/MS analysis was used for the first time to prepare a clinical sample containing the drugs mentioned above from different therapeutic groups. The effectiveness of our approach was compared with the precipitation method. The latter technique is usually used to prepare biological samples in routine laboratories. During the experiments, the substances of interest and the internal standard were separated from other matrix components using a prototype horizontal chamber for thin-layer chromatography/high-performance thin-layer chromatography (TLC/HPTLC) with a moving pipette powered by a 3D mechanism, which distributed the solvent on the adsorbent layer. Detection of the six antihypertensive drugs was performed by liquid chromatography coupled to tandem mass spectrometry (LC–MS/MS) in multiple reaction monitoring (MRM) mode. Results obtained by SFPE were very satisfactory (linearity R2 ≥ 0.981; %RSD ≤ 6%; LOD and LOQ were in the range of 0.06–9.78 ng/mL and 0.17–29.64 ng/mL, respectively). The recovery was in the range of 79.88–120.36%. Intra-day and inter-day precision had a percentage coefficient of variation (CV) in the range of 1.10–9.74%. The procedure is simple and highly effective. It includes the automation of TLC chromatogram development, which significantly reduced the number of manual operations performed, the time of sample preparation and solvent consumption.
Dyeing Properties, Color Gamut, and Color Evaluation of Cotton Fabrics Dyed with Phellodendron amurense Rupr. (Amur Cork Tree Bark)
Authors: Ji Xinyu , Zhao Zhijun , Ren Yulu , Xu Fei , Liu Jianhong
Published: February 2023

The application of plant dyes in the textile industry has been very limited due to their limited sources, incomplete color space, and narrow color gamut, etc. Therefore, studies of the color properties and color gamut of natural dyes and the corresponding dyeing processes are essential for completing the color space of natural dyes and their application. In this study, water extract from the bark of Phellodendron amurense (P. amurense) was used as a dye. Dyeing properties, color gamut, and color evaluation of dyed cotton fabrics were studied, and optimal dyeing conditions were obtained. The results showed that the optimal dyeing process was pre-mordanting with liquor ratio at 1:50, P. amurense dye concentration at 5.2 g/L, mordant concentration (aluminum potassium sulfate) at 5 g/L, dyeing temperature at 70 °C, dyeing time of 30 min, mordanting time of 15 min, and pH 5. Through the optimization of the dyeing process, a maximum color gamut range was obtained with lightness L* value from 74.33 to 91.23, a* value from −0.89 to 2.96, b* value from 4.62 to 34.08, chroma C* value from 5.49 to 34.09, and hue angle h° value from 57.35° to 91.57°. Colors from light yellow to dark yellow were obtained, among which 12 colors were identified according to the Pantone Matching Systems. The color fastness against soap-washing, rubbing, and sunlight on the dyed cotton fabrics all reached grade 3 level or above, further expanding the applicability of natural dyes.
It Takes Two to Tango, Part II: Synthesis of A-Ring Functionalised Quinones Containing Two Redox-Active Centres with Antitumour Activities
Authors: Oliveira Joyce C. , de Carvalho Renato L. , Sampaio Hugo G. S. , Honorato João , Ellena Javier A. , Martins Felipe T. , Pereira João V. M. , Costa Pedro M. S. , Pessoa Claudia , Ferreira Rafaela S. , Araújo Maria H. , Jacob Claus , da Silva Júnior Eufrânio N.
Published: February 2023

In 2021, our research group published the prominent anticancer activity achieved through the successful combination of two redox centres (ortho-quinone/para-quinone or quinone/selenium-containing triazole) through a copper-catalyzed azide-alkyne cycloaddition (CuAAC) reaction. The combination of two naphthoquinoidal substrates towards a synergetic product was indicated, but not fully explored. Herein, we report the synthesis of 15 new quinone-based derivatives prepared from click chemistry reactions and their subsequent evaluation against nine cancer cell lines and the murine fibroblast line L929. Our strategy was based on the modification of the A-ring of para-naphthoquinones and subsequent conjugation with different ortho-quinoidal moieties. As anticipated, our study identified several compounds with IC50 values below 0.5 µM in tumour cell lines. Some of the compounds described here also exhibited an excellent selectivity index and low cytotoxicity on L929, the control cell line. The antitumour evaluation of the compounds separately and in their conjugated form proved that the activity is strongly enhanced in the derivatives containing two redox centres. Thus, our study confirms the efficiency of using A-ring functionalized para-quinones coupled with ortho-quinones to obtain a diverse range of two redox centre compounds with potential applications against cancer cell lines. Here as well, it literally takes two for an efficient tango!
Metal and Ligand Effect on the Structural Diversity of Divalent Coordination Polymers with Mixed Ligands: Evaluation for Photodegradation
Authors: Govindaraj Manivannan , Zhong Shih-Ying , Lin Chia-Her , Chen Jhy-Der
Published: February 2023

Eight coordination polymers constructed from divalent metal salts, N,N′-bis(pyridin-3-ylmethyl)terephthalamide (L), and various dicarboxylic acids are reported, affording [Co(L)(5-ter-IPA)(H2O)2]n (5-tert-H2IPA = 5-tert-butylisophthalic acid), 1, {[Co(L)(5-NO2-IPA)]⋅2H2O}n (5-NO2-H2IPA = 5-nitroisophthalic acid), 2, {[Co(L)0.5(5-NH2-IPA)]⋅MeOH}n (5-NH2-H2IPA = 5-aminoisophthalic acid), 3, {[Co(L)(MBA)]⋅2H2O}n (H2MBA = diphenylmethane-4,4′–dicarboxylic acid), 4, {[Co(L)(SDA)]⋅H2O}n (H2SDA = 4,4-sulfonyldibenzoic acid), 5, {[Co2(L)2(1,4-NDC)2(H2O)2]⋅5H2O}n (1,4-H2NDC = naphthalene-1,4-dicarboxylic acid), 6, {[Cd(L)(1,4-NDC)(H2O)]⋅2H2O}n, 7, and {[Zn2(L)2(1,4-NDC)2]⋅2H2O}n, 8, which were structurally characterized by using single-crystal X-ray diffraction. The structural types of 1–8 are subject to the metal and ligand identities, showing a 2D layer with the hcb, a 3D framework with the pcu, a 2D layer with the sql, a polycatenation of 2-fold interpenetrated 2D layer with the sql, a 2-fold interpenetrated 2D layer with the 2,6L1, a 3D framework with the cds, a 2D layer with the 2,4L1, and a 2D layer with the (102⋅12)(10)2(4⋅10⋅124)(4) topologies, respectively. The investigation on the photodegradation of methylene blue (MB) by using complexes 1–3 reveals that the degradation efficiency may increase with increasing surface areas.
Involvement of GABAergic and Serotonergic Systems in the Antinociceptive Effect of Jegosaponin A Isolated from Styrax japonicus
Authors: He Lei , Zhou Ying , Ma Li , Wang Wencui , Yao Lei
Published: February 2023

The antinociceptive activity of the flower extracts of Styrax japonicus was confirmed in our previous study. However, the key compound for analgesia has not been distinguished, and the corresponding mechanism is obscure. In this study, the active compound was isolated from the flower by multiple chromatographic techniques and structurally illustrated using spectroscopic methods and referring to the related literature. The antinociceptive activity of the compound and the underlying mechanisms were investigated using animal tests. The active compound was determined to be jegosaponin A (JA), which showed significant antinociceptive responses. JA was also shown to possess sedative and anxiolytic activities but no anti-inflammatory effect, implying the association of the antinociceptive effects with the sedative and anxiolytic activities. Further antagonists and calcium ionophore tests showed that the antinociceptive effect of JA was blocked by flumazenil (FM, antagonist for GABA-A receptor) and reversed by WAY100635 (WAY, antagonist for 5-HT1A receptor). Contents of 5-HT and its metabolite (5-HIAA) increased significantly in the hippocampus and striatum tissues after JA administration. The results indicated that the antinociceptive effect of JA was regulated by the neurotransmitter system, especially GABAergic and serotonergic systems.
The Ultrashort Spike–Ring Interaction in Substituted Iron Maiden Molecules
Authors: Jabłoński Mirosław
Published: February 2023

The in forms of molecular iron maidens are known for their unique ultrashort interaction between the apical hydrogen atom or its small substituent and the surface of the benzene ring. It is generally believed that this forced ultrashort X⋯π contact is associated with high steric hindrance, which is responsible for specific properties of iron maiden molecules. The main aim of this article is to investigate the influence of significant charge enrichment or depletion of the benzene ring on the characteristics of the ultrashort C-X⋯π contact in iron maiden molecules. For this purpose, three strongly electron-donating (-NH2) or strongly electron-withdrawing (-CN) groups were inserted into the benzene ring of in-[34,10][7]metacyclophane and its halogenated (X = F, Cl, Br) derivatives. It is shown that, despite such extremely electron-donating or electron-accepting properties, the considered iron maiden molecules surprisingly reveal quite high resistance to changes in electronic properties.
Heterogenization of Heteropolyacid with Metal-Based Alumina Supports for the Guaiacol Gas-Phase Hydrodeoxygenation
Authors: Nunes Rita F. , Costa Daniel , Ferraria Ana M. , Botelho do Rego Ana M. , Ribeiro Filipa , Martins Ângela , Fernandes Auguste
Published: February 2023

Because of the global necessity to decrease CO2 emissions, biomass-based fuels have become an interesting option to explore; although, bio-oils need to be upgraded, for example, by catalytic hydrodeoxygenation (HDO), to reduce oxygen content. This reaction generally requires bifunctional catalysts with both metal and acid sites. For that purpose, Pt-Al2O3 and Ni-Al2O3 catalysts containing heteropolyacids (HPA) were prepared. HPAs were added by two different methods: the impregnation of a H3PW12O40 solution onto the support and a physical mixture of the support with Cs2.5H0.5PW12O40. The catalysts were characterized by powder X-ray diffraction, Infrared, UV-Vis, Raman, X-ray photoelectron spectroscopy and NH3-TPD experiments. The presence of H3PW12O40 was confirmed by Raman, UV-Vis and X-ray photoelectron spectroscopy, while the presence of Cs2.5H0.5PW12O40 was confirmed by all of the techniques. However, HPW was shown to strongly interact with the supports, especially in the case of Pt-Al2O3. These catalysts were tested in the HDO of guaiacol, at 300 °C, under H2 and at atmospheric pressure. Ni-based catalysts led to higher conversion and selectivity to deoxygenated compound values, such as benzene. This is attributed to both a higher metal and acidic contents of these catalysts. Among all tested catalysts, HPW/Ni-Al2O3 was shown to be the most promising, although it suffered a more severe deactivation with time-on-stream.
Tn5 DNA Transposase in Multi-Omics Research
Authors: Penkov Dmitry , Zubkova Ekaterina , Parfyonova Yelena
Published: February 2023

Tn5 transposase use in biotechnology has substantially advanced the sequencing applications of genome-wide analysis of cells. This is mainly due to the ability of Tn5 transposase to efficiently transpose DNA essentially randomly into any target DNA without the aid of other factors. This concise review is focused on the advances in Tn5 applications in multi-omics technologies, genome-wide profiling, and Tn5 hybrid molecule creation. The possibilities of other transposase uses are also discussed.
The Early History of Hydrogen and Other Gases in Respiration and Biological Systems: Revisiting Beddoes, Cavallo, and Davy
Authors: Hancock John T. , LeBaron Tyler W.
Published: February 2023

In 2007 a paper in Nature Medicine sparked a new wave of interest in the use of molecular hydrogen (H2) for medical treatments. Since then there has been a flurry of papers looking at a range of medical aspects, from neurodegenerative disease to sports injuries. Several methods of application have been developed, including breathing the gas, or making a hydrogen-rich solution that can be ingested, or administered as saline. H2 treatments are deemed to be safe and can be used in agricultural practice as well as in the biomedical arena. However, the first studies to investigate the use of H2 in medicine were carried out by those interested in the use of a range of gases and how this may affect respiration in humans. Beddoes was published in 1793 and Cavallo in 1798, with Davy following shortly after in 1800. With so many papers now appearing on H2 in biological systems, it seems timely, and interesting, to revisit the early papers, to humbly remind us of what these pioneers of respiratory research did.
Ultrabroadband OPA in YCOB with a sub-ps Pump Source
Authors: Pires Hugo , Alves Joana , Hariton Victor , Galletti Mario , João Celso , Figueira Gonçalo
Published: February 2023

We demonstrate the broadband optical parametric amplification of near-infrared laser pulses using a single yttrium calcium oxyborate (YCOB) crystal pumped in a noncollinear geometry by a sub-picosecond, milijoule-level source. The crystal uses an optimized orientation for phase matching outside of the principal planes, enabling ultrabroadband amplification (gain of ∼800) in the range of 750–950 nm and supporting down to 7 fs pulses.
The Activity and Stability of Promoted Cu/ZnO/Al2O3 Catalyst for CO2 Hydrogenation to Methanol
Authors: Berahim Nor Hafizah , Zabidi Noor Asmawati Mohd , Ramli Raihan Mahirah , Suhaimi Nur Amirah
Published: February 2023

Cu/ZnO/Al2O3 catalyst with the addition of tri-promoters (Mn/Nb/Zr) was investigated with respect to their catalytic activity and stability in a prolonged reaction duration in methanol synthesis. Spent catalysts were characterized using N2 adsorption-desorption, FESEM/EDX, TEM, N2O chemisorption, and XPS for their physicochemical properties. The catalyst longevity study was evaluated at two days, seven days, and 14 days at 300 °C, 31.25 bar, 2160 mL/g.hr GHSV, and H2:CO2 at 10:1. The CO2 conversion and methanol yield decreased by about 5.7% and 7.7%, respectively, when the reaction duration was prolonged to 14 days. A slight reduction in catalytic activity under prolonged reaction duration was found due to thermal degradation.
Inter-Weaving of Local and Global Discourses: History of Early Pentecostals in Kerala
Authors: Abraham Jose , Oommen George
Published: February 2023

Even though the Pentecostal movement in Kerala, South India, is a unique expression of Global Christianity, it has not been given due recognition either in the history of Kerala Christianity or Global Pentecostalism. It was rooted in both local and global discourses of the early 20th century. So, in order to understand the origin and early history of the Pentecostal movement, we need to delve deep into the history of socio-religious reform movements, which were enthusiastically embraced by Dalits, women, and other marginalized sections of Kerala. Unique features of Kerala Pentecostalism were shaped by various revival and reform movements among Christians in Kerala. With the arrival of American missionaries associated with the Azusa Street revival, the homegrown brand of Kerala Pentecostalism engaged in the global discourse on Pentecostalism. It equipped Pentecostals with the language and interpretations to make a break with the past and carve out a new identity for themselves. The usual method of approaching it as an extension of global Pentecostalism will not help us to understand how Pentecostals in Kerala creatively engaged in local and global discourses at the turn of the 20th century.
Secured and Privacy-Preserving Multi-Authority Access Control System for Cloud-Based Healthcare Data Sharing
Authors: Gupta Reetu , Kanungo Priyesh , Dagdee Nirmal , Madhu Golla , Sahoo Kshira Sagar , Jhanjhi N. Z. , Masud Mehedi , Almalki Nabil Sharaf , AlZain Mohammed A.
Published: February 2023

With continuous advancements in Internet technology and the increased use of cryptographic techniques, the cloud has become the obvious choice for data sharing. Generally, the data are outsourced to cloud storage servers in encrypted form. Access control methods can be used on encrypted outsourced data to facilitate and regulate access. Multi-authority attribute-based encryption is a propitious technique to control who can access encrypted data in inter-domain applications such as sharing data between organizations, sharing data in healthcare, etc. The data owner may require the flexibility to share the data with known and unknown users. The known or closed-domain users may be internal employees of the organization, and unknown or open-domain users may be outside agencies, third-party users, etc. In the case of closed-domain users, the data owner becomes the key issuing authority, and in the case of open-domain users, various established attribute authorities perform the task of key issuance. Privacy preservation is also a crucial requirement in cloud-based data-sharing systems. This work proposes the SP-MAACS scheme, a secure and privacy-preserving multi-authority access control system for cloud-based healthcare data sharing. Both open and closed domain users are considered, and policy privacy is ensured by only disclosing the names of policy attributes. The values of the attributes are kept hidden. Characteristic comparison with similar existing schemes shows that our scheme simultaneously provides features such as multi-authority setting, expressive and flexible access policy structure, privacy preservation, and scalability. The performance analysis carried out by us shows that the decryption cost is reasonable enough. Furthermore, the scheme is demonstrated to be adaptively secure under the standard model.
Fast and Robust Infrared Small Target Detection Using Weighted Local Difference Variance Measure
Authors: Zheng Ying , Zhang Yuye , Ding Ruichen , Ma Chunming , Li Xiuhong
Published: February 2023

Infrared (IR) small-target-detection performance restricts the development of infrared search and track (IRST) systems. Existing detection methods easily lead to missed detection and false alarms under complex backgrounds and interference, and only focus on the target position while ignoring the target shape features, which cannot further identify the category of IR targets. To address these issues and guarantee a certain runtime, a weighted local difference variance measure (WLDVM) algorithm is proposed. First, Gaussian filtering is used to preprocess the image by using the idea of a matched filter to purposefully enhance the target and suppress noise. Then, the target area is divided into a new tri-layer filtering window according to the distribution characteristics of the target area, and a window intensity level (WIL) is proposed to represent the complexity level of each layer of windows. Secondly, a local difference variance measure (LDVM) is proposed, which can eliminate the high-brightness background through the difference-form, and further use the local variance to make the target area appear brighter. The background estimation is then adopted to calculate the weighting function to determine the shape of the real small target. Finally, a simple adaptive threshold is used after obtaining the WLDVM saliency map (SM) to capture the true target. Experiments on nine groups of IR small-target datasets with complex backgrounds illustrate that the proposed method can effectively solve the above problems, and its detection performance is better than seven classic and widely used methods.
Endosome and Lysosome Membrane Properties Functionally Link to γ-Secretase in Live/Intact Cells
Authors: Houser Mei C. Q. , Mitchell Shane P. C. , Sinha Priyanka , Lundin Brianna , Berezovska Oksana , Maesako Masato
Published: February 2023

Our unique multiplexed imaging assays employing FRET biosensors have previously detected that γ-secretase processes APP C99 primarily in late endosomes and lysosomes in live/intact neurons. Moreover we have shown that Aβ peptides are enriched in the same subcellular loci. Given that γ-secretase is integrated into the membrane bilayer and functionally links to lipid membrane properties in vitro, it is presumable that γ-secretase function correlates with endosome and lysosome membrane properties in live/intact cells. In the present study, we show using unique live-cell imaging and biochemical assays that the endo-lysosomal membrane in primary neurons is more disordered and, as a result, more permeable than in CHO cells. Interestingly, γ-secretase processivity is decreased in primary neurons, resulting in the predominant production of long Aβ42 instead of short Aβ38. In contrast, CHO cells favor Aβ38 over the Aβ42 generation. Our findings are consistent with the previous in vitro studies, demonstrating the functional interaction between lipid membrane properties and γ-secretase and provide further evidence that γ-secretase acts in late endosomes and lysosomes in live/intact cells.