bluuebunny/crossref_metadata_2025 huggingface dataset:
Afectaciones subjetivas y prácticas de resistencia de mujeres makaguán de Fortul, Arauca, víctimas del desplazamiento forzado
Authors: Ortiz-Piedrahita Vanessa , Baron-Gómez Aura
Published: September 2023

La presente investigación se enmarca en el campo de las ciencias sociales y tiene como objetivo primordial identificar las afectaciones subjetivas y las respectivas prácticas de afrontamiento y resistencia desarrolladas por un grupo de mujeres indígenas makaguán de Fortul, Arauca, víctimas del conflicto armado en Colombia. Esta investigación se desarrolló a través de un lente teórico interseccional. En otras palabras, se analizó historias de vida atravesadas por hechos violentos en Colombia, desde una perspectiva de género, etnicidad y clase social. En términos metodológicos y epistémicos, esta investigación se construyó a partir de un abordaje hermenéutico/cualitativo y decolonial, de modo que se privilegió las voces y discursos de aquellas mujeres víctimas del conflicto armado en Colombia. Uno de los principales hallazgos de la investigación hizo referencia al deseo de reintegración social a su resguardo de origen; territorio del cual fueron expulsadas hace una década. En efecto, producto del desplazamiento, las mujeres makaguán y sus familias han sufrido afectaciones materiales, subjetivas y simbólicas hasta el presente. Pese a que en 2018 la comunidad ganó una tutela interpuesta ante el Ministerio de Interior, ellas aún no se han reintegrado a su resguardo de origen. Se han realizado varios intentos por restituir sus derechos, sin embargo, no se ha logrado llegar a un consenso claro entre las autoridades del resguardo Cusay la Colorada en Fortul, Arauca, las mujeres desplazadas y la institucionalidad local (Alcaldía y Gobernación). Actualmente se están realizando acercamientos entre las partes involucradas, con el objetivo de restituir principios humanos violados, como los relacionados con el derecho a la vida, territorio, identidad cultural, autonomía y participación comunitaria. El artículo concluye con algunas sugerencias y recomendaciones para la efectiva implementación de la política pública de víctimas de la violencia en Fortul, con base en un enfoque de género, diferencial y acorde a los planes de vida de la comunidad makaguán.
Comparación ecotoxicológica al Cloruro de Sodio en Hydra vulgaris e Hydra viridissima
Authors: Barrera Herrera July Andrea , Espinosa Ramírez Adriana Janneth
Published: September 2023

El aumento de la salinidad en los ecosistemas de agua dulce genera preocupación sobre los efectos adversos que puede provocar sobre las especies dulceacuícolas y el suelo. Las concentraciones óptimas de iones de sodio y calcio para que las especies del género Hydra tengan condiciones fisiológicas adecuadas son relativamente bajas. Este trabajo se enfocó en comparar la sensibilidad de H. vulgaris e H. viridissima frente al cloruro de sodio (NaCl). Las especies fueron mantenidas bajo condiciones de fotoperiodo, iluminación y temperatura controladas. Se obtuvieron las tasas de crecimiento y en ensayos de toxicidad aguda se calcularon las CE50 (Concentración efectiva media) y CL50 (Concentración letal media) como indicadores de la sensibilidad al NaCl. H. vulgaris fue más sensible al NaCl dado que la CL50-96h fue de 1,0 g/l NaCl (entre 0,8 – 1,2 g/l como intervalo de confianza al 95%), mientras que H. viridissima presentó una CL50-96h promedio de 2,6 g/l (entre 2,0 – 3,3 g/l como intervalo de confianza del 95%). Se considera que esta última fue más tolerante al NaCl, probablemente por la relación simbiótica con la microalga Chlorella vulgaris, ya que podría generar un efecto protector. Se espera que comprender el comportamiento de estos biomodelos respecto al aumento de la salinización permita la evaluación temprana de riesgos ecológicos en ecosistemas acuáticos tropicales.
Evaluación y caracterización de la sirtuina 2.3 de Giardia duodenalis (GdSir2.3)
Authors: Suárez Jurado Aravy Geohanna , Ramirez Hernandez Maria Helena , Jair Diaz Gonzalo
Published: September 2023

La giardiasis es la enfermedad gastrointestinal de mayor incidencia mundial, causada por el protozoario Giardia duodenalis, para la cual no se cuenta con una vacuna o tratamiento eficiente. En aras de buscar nuevos blancos farmacológicos contra este parásito, se han estudiado las enzimas del metabolismo energético, como las sirtuinas, deacetilasas dependientes del dinucleótido de adenina y nicotinamida (NAD). Previamente se identificó a GdSir2.1 y GdSir2.2 como deacetilasas dependientes de NAD, con localizaciones subcelulares diferentes.
En este trabajo se estudió otro candidato a sirtuina (GdSir2.3) mediante herramientas bioinformáticas para la identificación de características típicas de la familia sirtuina en la secuencia del candidato, y experimentales como la obtención de la proteína recombinante 6xHis-GdSir2.3 que demostró actividad deacetilasa dependiente de NAD y que sirvió como antígeno en la producción de los IgY - α - 6xHis-GdSir2.3 para la localización subcelular de la proteína endógena en G. duodenalis. Lo anterior concuerda con otros estudios donde se señala a GdSir2.3 como un importante regulador de la enquistación, debido a su aumento de expresión durante esta etapa del ciclo de vida, constituyéndola como un blanco farmacológico promisorio para el control de esta parasitemia.
Síntesis y actividad antifúngica in vitro frente a Fusarium oxysporum de amidas N-alquilsustituidas derivadas de 2-aminoácidos
Authors: Borrego-Muñoz Paola , Quiroga Diego Enrique , Coy-Barrera Ericsson
Published: September 2023

Una serie de amidas N-alquilsustituidas 1-16 fueron sintetizadas a partir de malonato de dietilo y ésteres de alquilo derivados de los aminoácidos ʟ-triptófano, ʟ-alanina, ʟ-fenilalanina y ʟ-tirosina. Los métodos de síntesis empleados involucraron calentamiento por irradiación de microondas empleando tanto un ácido de Lewis (AlCl3) o 4-dimetilaminopiridina (DMAP) como catalizador y auxiliar nucleofílico, respectivamente. Los resultados sugieren que el uso de irradiación de microondas y de DMAP conlleva mejores rendimientos en un tiempo de reacción más corto. Para ilustrar las diferencias observadas, se presentan las propuestas mecanísticas de cada método de reacción para la formación de amidas N-alquilsustituidas. Finalmente, las amidas sintetizadas se evaluaron en condiciones in vitro frente a Fusarium oxysporum; mostraron actividad antifúngica a diferentes niveles (0,40 mM < IC50 < 29,1 mM), lo cual indicó que las variaciones de la actividad observada de este grupo de compuestos pueden deberse al efecto de la amida acíclica como bioisóstero no clásico de algunas fitoalexinas heterocíclicas.
Cultivo de explantes de adenocarcinoma gástrico humano: Modelo para la evaluación de la actividad oncolítica del rotavirus Wt1-5
Authors: Sossa-Rojas Henry , Franco-Maz Pedro Gabriel , Zapata-Acevedo Carlos Manuel , Guerrero-Fonseca Carlos Arturo
Published: September 2023

Introducción. A nivel mundial, el cáncer gástrico es el quinto cáncer más comúnmente diagnosticado y la cuarta mayor causa de mortalidad por cáncer. Los virus oncolíticos son un agente terapéutico potencial para el cáncer. Objetivo. Evaluar la capacidad de penetración, la selectividad y la eficiencia oncolítica del rotavirus Wt1-5 mediante un modelo de infección ex vivo en muestras tumorales obtenidas de pacientes con diagnóstico de adenocarcinoma gástrico. Materiales y métodos. Estudio experimental de laboratorio realizado en explantes de adenocarcinoma gástricos de subtipo-difuso e intestinal recolectados en el Hospital Universitario de la Samaritana (Bogotá D.C., Colombia). Estos explantes se infectaron con el rotavirus Wt1-5 y, mediante pruebas inmunohistoquímicas, se evaluó su capacidad de penetración y difusión a través del microambiente tumoral, así como su potencial como virus oncolítico. Los datos se describen usando medias y desviaciones estándar. Además, se realizó un análisis bivariado mediante la prueba de U de Mann-Whitney para determinar las diferencias entre los datos de los ensayos evaluados y el control empleado en cada uno. Se consideró un nivel de significancia estadística de p <0.05. Resultados. A las 12 horas post infección (h.p.i) se observó que el rotavirus Wt1- se había diseminado en todas las capas del tumor, lo cual favoreció la infección de las células tumorales y generó necrosis del tejido tumoral a partir de las 48 h.p.i. Por otro lado, los tejidos no-tumorales adyacentes no mostraron evidencia de infección con este rotavirus, ni lisis tisular (p<0.05). Conclusiones. El cultivo de explantes es un modelo útil para estudiar y predecir el comportamiento infeccioso ex vivo. El rotavirus Wt1-5 infecta de manera selectiva y eficiente las células tumorales en explantes de adenocarcinoma gástrico, tanto del subtipo difuso como del subtipo intestinal.
Bioimpresión 3D: imprimiendo oportunidades de vida
Authors: Medina Gamero Aldo , Regalado Chamorro Mónica , Rosario Pacahuala Emilio
Published: September 2023

La impresión 3D, por sí sola, es la adición de material en capas que corresponden a las sucesivas secciones transversales de un modelo 3D. Losplásticos y las aleaciones de metal son los materiales más usados en esteproceso, pero se puede utilizar casi cualquier material, desde hormigónhasta tejido vivo.1 Este último ha venido causando una revelación en elcampo de la Medicina, ya que esta tecnología permitiría obtener un nuevo tejido u órgano sin necesidad de un donador, lo cual salvaría muchasvidas, debido a que muchos pacientes mueren esperando un trasplante.
Viruela símica: ¿un peligro para la salud pública mundial?
Authors: Minchola-Castañeda Kevin , Mozo-Marquina Renzzo
Published: September 2023

La viruela símica o viruela del mono es una zoonosis causada por el virus monkeypox (MPXV, del inglés “monkeypox virus”), virus del género Orthopoxvirus de la familia Poxviridae, y que tiene como reservorio a primates y roedores pequeños de los bosques tropicales de África Occidental y Central, donde es una infección endémica.1
Study of the physicochemical and mechanical stability of an edible leather of mango (Mangifera indica) and pineapple (Ananas comosus) pulp
Authors: Bravo-Buitrago Jeinson Estiven , Ciro-Velásquez Hector José , Márquez-Cardozo Carlos Julio
Published: September 2023

Mango (Mangifera indica) and pineapple (Ananas comosus) are two important fruits with many industrial uses and excellent sensory, nutritional and functional characteristics. In this research work, the development of intermediate moisture edible leathers obtained by convective drying technology of the mixture of mango and pineapple pulp at 60 and 70 °C was carried out, evaluating their physicochemical characterization and stability under controlled storage conditions at 25 and 35 °C. The results showed that leathers subjected to drying at 60 °C and stored at 35 °C presented a significant increase in water activity. Leathers stored at 35 °C showed greater browning due to the effect of storage temperature. The highest resistance to cutting and tension was observed in edible leathers dried at 70 °C and stored at 25 °C. The Young's Modulus in tension varied between 1.317 and 2.22 MPa. The greatest degradation of vitamin C (57%) was found in leathers dried at 70 °C and stored at 35 °C. It was possible to conclude that the mango and pineapple pulp-based leathers stored for 4 weeks presented physical-chemical and techno-functional characteristics that make them suitable for consumption.
The impact of credit on agricultural productivity of Musaceae: evidence from Valle Del Cauca, Colombia
Authors: Rivera-Acosta Javier , Xu Xiuchuan
Published: September 2023

This study evaluates the impact of agricultural credit on productivity of Musaceae (banana and plantain) in farmers from Valle del Cauca (Colombia) using data from National Agricultural Census of 2014. Additionally, the effect of credit on two productivity indices (PI1 y PI2) was evaluated, PI1 measured in tons of production per hectare and PI2 in ton of production per employee. To evaluate this impact, the counterfactual without treatment was estimated using the information of those farmers who obtained a credit and similar farmers who did not. Therefore, to control the selection bias, derived from the fact that the credits are not awarded randomly, this study uses the Propensity Score Matching (PSM) methodology applying the 4-nearest neighbor matching algorithm. In general, for banana producers, the results suggest that access to agricultural credit has positive and significant effects with an increase in productivity per hectare (PI1) of 8.4%; on the other hand, for PI2 the result was not statistically significant, however, it may be an indicator that the farmer is not using human resources efficiently to achieve the increase obtained in PI1 . Finally, this study suggests that access to agricultural credit may not be decisive in increasing the productivity of the plantain crop, given that the effect on the two indices evaluated was indeterminate.
Influence of drying air temperature on coffee quality during storage
Authors: Peñuela Martínez Aida Esther , Sanz Uribe Juan Rodriguez , Medina Rivera Rubén Darío
Published: September 2023

Drying is the most important stage for maintaining coffee quality. The temperature conditions at which drying is performed can affect bean integrity. This research was developed with the aim of determining the effect of mechanical drying air temperature on the quality of coffee during storage and verifying its effect on the generation of bleached beans evaluating two air temperatures at 50 and 40 °C, and solar drying was used as a control, using an experimental design of random blocks with 10 blocks. The response variables were related to beans color and sensory quality. The analysis of repeated measures indicated that there were differences in the initial color of the coffee beans due to the effect of the treatments and the storage time. A greater magnitude of color change was obtained for coffee dried at 50 °C and that dried with solar drying. Germination was lower and different for the 50 °C treatment. This treatment also showed greater fat content since the beginning of the storage; meanwhile, the two other treatments just presented greater fat content at the end of the experiment. Regarding to sample proportion of clean cups, the multiple comparison Tukey–Kramer test was significantly different in terms of favoring solar drying at 40 °C. The effect of the drying conditions on beans has not been appreciated; however, the deterioration generated during this stage occurs during storage and manifests itself in a loss of quality, with an increase in defects.
Patrón de tinción de anticuerpos antinucleares en pacientes con diagnóstico de enfermedades autoinmunes en Manabí, Ecuador
Authors: Urdaneta Bracho Johan , Rodríguez Peralta Juan Carlos , Callejas de Valero Diana , Cañarte Alcívar Jorge , Semprún Blanca Irene , Carrero Castillo Yenddy Nayghit
Published: September 2023

Objetivos Detectar el patrón de tinción de anticuerpos antinucleares (ANA) en pacientes con diagnóstico presuntivo de enfermedades autoinmunes (EIA).
Materiales y Métodos Se realizó un estudio en 2507 pacientes derivados a un laboratorio privado a los cuales se les detectó ANA mediante la técnica de Inmunofluorescen- cia indirecta (IFI) tomando en consideración criterios éticos.
Resultados Del total de pacientes estudiados, 743 pacientes (29,6 %) resultaron positivos. En cuanto a las características de la población, el sexo femenino y el grupo etario de 40 a 59 años fueron los más prevalentes, con 82,6 % y 41,2 %, respectivamente. Asimismo, 44,8 % mostraron títulos de 1/80. El patrón moteado fue el más frecuente, con 47,2 %, seguido del sub-patrón moteado fino, con un 35,7 %.
Conclusiones Es importante establecer parámetros asociados al diagnóstico de EAI en diversas zonas donde no se conocen datos precisos, así como otros hallazgos fortuitos ante la positividad de ANA. Es imperativo describir las características de la población, los patrones encontrados y los títulos. Resulta relevante la correlación de ANA con otras patologías en la actualidad, como la infección por SARS-CoV-2 y otros agentes de importancia clínica.
Demographic sustainability in Italian territories: The link between depopulation and population ageing
Authors: Reynaud Cecilia , Miccoli Sara
Published: September 2023

Since the Second World War, Italy has experienced major demographic changes, including increasing survival, decreasing fertility and higher rates of immigration. These changes have silently and slowly led to important shifts in the structure and the territorial distribution of the population. Thus, like in many other European countries, population ageing and depopulation have become the most relevant demographic phenomena in Italy. In this paper, we studied the relationship between depopulation and ageing in Italian territories in the 1971–2019 period using the census data of the Italian municipalities and applying spatial techniques. We found that high levels of depopulation later result in high levels of population ageing, and that recent population ageing processes are also connected to ongoing depopulation processes, thereby creating a vicious circle.
Experimental exposure of rainbow trout eggs to water mould, Saprolegnia parasitica (Oomycota): intraspecific differences in pathogenicity
Authors: Hardy Tímea , Erdei Noémi , Sipos Dóra , Verebélyi Viktória , Eszterbauer Edit
Published: September 2023

In in vivo infection trials, rainbow trout eyed eggs were exposed to three Saprolegnia parasitica (Oomycota) isolates, which differed in biological and genetic characteristics. Infection prevalence, hatching rate, hatching dynamics of fish eggs were quantified, and the study was complemented with histopathology and phylogenetic analyses. We experimentally detected intraspecific differences in the pathogenicity of S. parasitica on rainbow trout eggs. The isolate from rainbow trout eggs was the most virulent to eggs of the same host, whereas isolates from carp skin and fry did not cause as much damage to the eggs. Comparing the outcome of two experimental settings, we confirmed that invasion of fish eggs is more effective by hyphae growth than by the actively moving zoospores. In addition, our findings highlighted that S. parasitica isolates with 100% identical ITS DNA sequences, could differ significantly in virulence. These isolates can be clearly distinguished based on a 650-bp DNA fragment of the DNA-directed RNA polymerase II subunit (RPB2) gene.
Wybrane aspekty związane z akwakulturami makroglonów na przykładzie Neopyropia (Porphyra)
Authors:   Zakład Gleboznawstwa, Chemii Środowiska i Hydrologii, Noga Teresa , Kochman-Kędziora Natalia ,   Zakład Ekologii i Ochrony Środowiska, Uniwersytet Rzeszowski
Published: September 2023

For thousands of years algae have been used for food and agricultural purposes in Asian countries. In recent years they have become increasingly popular in aquaculture, especially in the integrated multitrophic aquaculture (IMTA), in which they process waste produced by fish, rich in, among others, into ammonia, phosphates and carbon, while producing new biomass. Products containing algae are characterized by a high content of protein, vitamins and minerals and are more often chosen by consumers, e.g. due to the trend towards healthy eating. Commercially grown species of the genus Neopyropia (syn. Porphyra, nori) are a valuable source of nutrients and can contribute to meeting the growing nutritional needs in the world. The article summarizes the latest literature on the use of Neopyropia macroalgae in aquaculture and food industry. Attention was also paid to the potential dangers resulting from contamination of algae products, mainly with heavy metals.
Kształcenie w zakresie podstaw statystyki na wybranych kierunkach studiów Uniwersytetu Rzeszowskiego – analiza SWOT
Authors:   Zakład Podstaw Rolnictwa i Gospodarki Odpadami, Kolegium Nauk Przyrodniczych, Instytut Nauk Rolniczych, Ochrony i Kształtowania Środowiska, Uniwersytet Rzeszowski, Podolak Agnieszka , Kasprzyk Karina ,   studentka kierunku Logistyka w sektorze rolno-spożywczym, Uniwersytet Rzeszowski, Semenowicz Kinga ,   studentka kierunku Logistyka w sektorze rolno-spożywczym, Uniwersytet Rzeszowski, Małek Małgorzata ,   studentka kierunku Logistyka w sektorze rolno-spożywczym, Uniwersytet Rzeszowski
Published: September 2023

The article makes an attempt at assessing the quality of education in the subject "Basics of statistics" and inidicates proposals for actions that may improve its effectiveness using the SWOT analysis. The results were obtained thanks to cooperation with first-cycle students of Renewable Energy Sources and Waste Management Logistics in the Agri-Food Sector, Environmental Protection and Agriculture at the College of Natural Sciences of the University of Rzeszów. The answers obtained indicate many positive aspects of the current education process, while highlighting weaknesses and signalling threats that may occur in the future. The findings received may therefore be helpful in increasing the effectiveness of teaching other subjects as well.
Skala transportu zwierząt gospodarskich w Unii Europejskiej
Authors:   Zakład Produkcji Zwierzęcej i Oceny Produktów Drobiarskich, Kolegium Nauk Przyrodniczych, Uniwersytet Rzeszowski, Topczewska Jadwiga
Published: September 2023

Agricultural policy and the profitability of production are conducive to the movement of animals not only for slaughter, but also for pig fattening or cattle fattening. The largest producers transport animals both in intra-EU trade and to third countries. Transporting animals, especially over long distances, involves significant environmental costs. In contrast, the transport of carcasses or meat is more beneficial in terms of its impact on the environment and climate change. It appears that changes in this area may be accelerated by pressure from consumer choices.
Development of Theoretical Ideas About the City: Cartography and Mental Maps in Sociological Discourse
Authors:   Volgograd State University, Fursaev Lev , Poltavskaya Mariya ,   Volgograd State University
Published: September 2023

The relevance of urban studies is growing with the increase population in cities, these trends have been observed worldwide for more than half a century. The main task of the presented work is to identify the stages of development of theoretical ideas about the city: from theories based on the historical and comparative method developed by the classics of sociological thought (F. Tönnies, G. Simmel, M. Weber) before the research of the second half of the 20th century, in which the accumulated sociological knowledge and methods allow enriching interdisciplinary research matrices (K. Lynch, S. Milgram). The transformation of urban research is determined by socio-cultural, economic, demographic and political factors in a particular space and time, which allows us to constantly formulate new hypotheses. The perception of the city changes with the development of knowledge: from utilitarian to meaning-forming, spiritual space. The concept of "image of the city" is considered in this study as a key one that determines the strategy of scientific research and the inclusion in the research discourse of works devoted to cartography and the development of mental maps (K. Lynch, S. Milgram, I.I. Mitin et al.). K. Lynch created mental maps based on the logic of perception of the fabric of the urban environment; maps revealed the connection between the real objects of the city and the respondents' ideas about them; the townspeople perceived the city individually, extrapolating their meanings to familiar streets and architectural objects. S. Milgram continued to develop the ideas of mental mapping. He transferred the research to the plane of personal perception: a person emotionally colors the city. These methods of studying the city make it possible to evaluate its functionality and infrastructure, to identify the daily practices of citizens, which becomes the basis formation of the "image of the city", definitions elements that make the city safe and accessible or vice versa lead to alienation. The conclusions obtained as a result of the study make it possible to form an interdisciplinary research matrix within the framework of urban sociology, to obtain a sociological interpretation of the knowledge obtained about the object of research in history, geography, cultural studies, philosophy, demography, which contributes to the expansion of research prospects and the development of related fields of knowledge.
Ideas of Postmodernism Philosophy as a Tool for Social Reality Representation in Leonid Gaidai Movie Films
Authors:   Volgograd State University, Gorkov Aleksandr
Published: September 2023

The author initiates research for Leonid Gaidai works ideology concept, challenging the point of view stating that Leonid Gaidai movie films have no ideas at all, presenting "simple comedies". The article is analyzing Leonid Gaidai typical movie film plots and movie making methods correlation to primary ideas of postmodernism philosophy. Based on such examples as "The Diamond Arm", "Kidnapping, Caucasian Style", "Ivan Vasilievich: Back to the Future", "A Groom from the Other World", "Operation Y and Shurik's Other Adventures" the author justifies typical film plots and movie making methods relevance to postmodernism ideas of hypertextuality, temptation subjugating human will (loss of subjectivity), constant facing to and power of simulacrum, focus on competing micronarratives. The author uses data of social reality research in USSR at 1930-s and 1950-s to state hypothesis about routes and reasons of Leonid Gaidai representing exactly postmodernism philosophy ideas. The author justifies catharsis effect is the reason for Leonid Gaidai movie films success, the catharsis causing merge of film audience recognition with art representation image and consequent decrease or elimination of anxiety, stress because of conflicts, frustration feeling. The author demonstrates consistent patterns of destructive, pessimistic tendencies of postmodernism situation appearance within social reality utilizing Leonid Gaidai movie films data, philosophy of postmodernism works (Baudrillard, Liotar) and classical philosophy (Aristotle). The author states hypothesis that Leonid Gaidai movie films success with audience right after distribution start and nowadays, when being showed on the most popular Russian TV channels at prime time, justifies postmodernism ideas relevance to soviet and post-soviet, modern social reality.
THE COOLING CAPACITY OF NATURAL GASES FOR CIRCULAR/RECTANGULAR GEOMETRIES BY IMPINGING JET
Authors: Mardani Mohammad , Pesteei Seyyed Mehdi
Published: September 2023

In this work, influences of the variety of parameters on the heat-transfer forced convection of two confined impinging jets, such as inlet geometry and mass-flow rate, have been investigated numerically. Simulations were done using a 3D k - ε model for incompressible flow on two jet exit geometries comprising rectangular and circular jets at the dimensionless jet-to-plate distance of 2. A finite-volume method was employed to discretize the equations. Local Nusselt number was obtained for various mass-flow rates and geometries for air and pure gases of oxygen, nitrogen, argon, and carbon dioxide at a dimensionless jet-to-plate distance of 2. As the mass-flow rate increases, heat-transfer enhancement is obtained. The CO2 gas has the highest level of the Nusselt number in comparison with others, and around 40% increases the rate of heat transfer compared to the air; thus, it could be beneficial in the cooling process rather than other gases. Also, this study revealed that the forced-convection heat transfer in the circular jet has a higher amount than the rectangular jet.
Bio-cementation of tailings sands using ultraviolet-induced urease-producing bacteria
Authors: Xu Kai , Huang Ming , Zhang Jinxuan , Cui Mingjuan , Xu Chaoshui
Published: September 2023

The disposal of tailings in a safe and environmentally friendly manner has always been a challenging issue. The microbially induced carbonate precipitation (MICP) technique is used to stabilise tailings sands. MICP is an innovative soil stabilisation technology. However, its field application in tailings sands is limited due to the poor adaptability of non-native urease-producing bacteria (UPB) in different natural environments. In this study, the ultraviolet (UV) mutagenesis technology was used to improve the performance of indigenous UPB, sourced from a hot and humid area of China. Mechanical property tests and microscopic inspections were conducted to assess the feasibility and the effectiveness of the technology. The roles played by the UV-induced UPB in the processes of nucleation and crystal growth were revealed by scanning electron microscopy imaging. The impacts of elements contained in the tailings sands on the morphology of calcium carbonate crystals were studied with Raman spectroscopy and energy-dispersive X-ray spectroscopy. The precipitation pattern of calcium carbonate and the strength enhancement mechanism of bio-cemented tailings were analysed in detail. The stabilisation method of tailings sands described in this paper provides a new cost-effective approach to mitigating the environmental issues and safety risks associated with the storage of tailings.
A Novel High-Content Screening Assay Identified Belinostat as Protective in a FSGS—Like Zebrafish Model
Authors: Schindler Maximilian , Siegerist Florian , Lange Tim , Simm Stefan , Bach Sophia-Marie , Klawitter Marianne , Gehrig Jochen , Gul Sheraz , Endlich Nicole
Published: September 2023

Background

FSGS affects the complex three-dimensional morphology of podocytes, resulting in loss of filtration barrier function and the development of sclerotic lesions. Therapies to treat FSGS are limited, and podocyte-specific drugs are unavailable. To address the need for treatments to delay or stop FSGS progression, researchers are exploring the repurposing of drugs that have been approved by the US Food and Drug Administration (FDA) for other purposes.

Methods

To identify drugs with potential to treat FSGS, we used a specific zebrafish screening strain to combine a high-content screening (HCS) approach with an in vivo model. This zebrafish screening strain expresses nitroreductase and the red fluorescent protein mCherry exclusively in podocytes (providing an indicator for podocyte depletion), as well as a circulating 78 kDa vitamin D—binding enhanced green fluorescent protein fusion protein (as a readout for proteinuria). To produce FSGS-like lesions in the zebrafish, we added 80 µM metronidazole into the fish water. We used a specific screening microscope in conjunction with advanced image analysis methods to screen a library of 138 drugs and compounds (including some FDA-approved drugs) for podocyte-protective effects. Promising candidates were validated to be suitable for translational studies.

Results

After establishing this novel in vivo HCS assay, we identified seven drugs or compounds that were protective in our FSGS-like model. Validation experiments confirmed that the FDA-approved drug belinostat was protective against larval FSGS. Similar pan-histone deacetylase inhibitors also showed potential to reproduce this effect.

Conclusions

Using an FSGS-like zebrafish model, we developed a novel in vivo HCS assay that identified belinostat and related pan-histone deacetylase inhibitors as potential candidates for treating FSGS.
Sensing As… From Quorum Sensing to Immersion – A Posthuman Symptomatology
Authors: Psarologaki Liana
Published: September 2023

This is an investigative attempt to create a hopeful new becoming of thought. It comes in response to contemporary issues of care, the schism between, and respective weaknesses of both sciences and humanities to advance with each other and pressing issues of climate and social justice. It aims to determine the potential of a new interdisciplinarity (an inter-disciplination) of posthumanities through three critical and contextual tactics: Deleuze’s symptomatology, Shaviro’s science fiction and Frichot’s dirty theory maintaining an ecofeminist perspective. It examines maladies of anthropocentricism, problematics of institutionalised interdisciplinarity and lost cultures of contemplation. It uses science fiction and what-if/what-it-is-like scenarios to advocate for a new organism-environment entity defined as ‘slyborg’ (a slut-cyborg). It starts with definitions of posthuman life and zöe by Rosi Braidotti which, together with studies on neurobiology, lead us to an affirmation of organism-environment survival necessity. Helene Frichot’s creative ecology of dirty theory brings methodological inoculations that consider the unclean and smudged, the ambivalent and non-linear as potentiality for hopeful futures. These are not bound to the bias created by Eurocentric male-dominated traditions of superiority and lead to hypotheses freed from normative and institutionalised constructs. The essay explores sensing with the world affirming life around two concepts: quorum sensing and immersion. It assigns these to the slyborg as definitive characteristics beyond species and territory, implying therefore that the slyborg is post-anthropocentric – an entity-topos. It concludes with a hopeful scenario that the slyborg is ready to emerge as hopeful ecosystemic transformation born out crisis
Redistribution of Resources between the Private and Public Sectors of the Spatial Economy: An Agent-Based Approach
Authors:   Institute of Economics and Industrial Engineering of the Siberian Branch of RAS, Suslov V. I. ,   Novosibirsk State University, Tsyplakov A. A. ,   Institute of Economics and Industrial Engineering of the Siberian Branch of RAS,   Novosibirsk State University, Novikova T. S. ,   Institute of Economics and Industrial Engineering of the Siberian Branch of RAS,   Novosibirsk State University,   Novosibirsk State Technical University
Published: September 2023

Redistribution of resources between the private and public sectors is a key issue of state policy analysis, including at the regional level. The article examines how changes in tax rates and social transfers affect the redistribution of financial resources, fixed capital and labour. The study utilised a spatial agent-based model focused on microeconomic decisions of households and enterprises. Fixed capital depends on investment policies of private and public companies; demand and supply are balanced in the labour market for a given total labour force. Tax rates and distribution of social transfers are seen as the institutional framework for making microeconomic decisions. At the meso- and macro-levels, state policy changes affect the economic structure of regions, industries, public and private sectors. The use of capital, labour and financial resources was assessed to calculate the relative size of the public sector. Simulations of changes in transfers and taxes show opposite trends in the proportion of the sectors. At given tax rates, the expansion of social transfers reduces social inequality and causes profound structural changes in the economy due to decreased provision of public goods and increased income of recipient households. The size of the public sector in terms of the use of financial resources remains practically unchanged: its share in gross domestic product decreased from 32.2 % to 30.4 %. However, the shares of capital (by 9.9 %) and labour (by 14.7 %) noticeably declined in this sector, indicating a redistribution of capital and labour from the public to the private sector. On the contrary, tax hike leads to an increase in the main indicators characterising the share of the public sector, while most of the private sector indicators fall sharply and social inequality rises significantly.
Creative Reindustrialisation of the Second-Tier Cities in the Digital Transformation Era: A Study Using SciVal Tools
Authors:   Ural Federal University, Turgel I. D. , Antonova I. S. ,   Tomsk Polytechnic University,   Tomsk State University
Published: September 2023

Nowadays, creative industries are becoming a driving force for urban economic development, inspiring the emergence of a new conceptual framework in regional economy, which includes the notion of «creative reindustrialisation of cities». Traditionally, scientific review is used to present theoretical and methodological foundations of a new subject area. However, individual use of such tools as author search or information systems analysis does not allow for a comprehensive scientific review on the emerging topic. The study aims to substantiate the creation of a new subject area, focused on the creative reindustrialisation of the second-tier cities in the digital transformation era, and to identify theoretical and practical trends in its development. To this end, the following steps were performed: identifying specific elements and establishing a general model of the subject area; comparing model and existing elements; modelling the new subject area using the developed logical scheme; analysing the new subject area and comparing it with existing ones. Since the examined subject area is not presented in the SciVal system, this paper developed the logical scheme for creating a new subject area through keywords, and proposed four models. After the models were tested using the SciVal tools, the subject area of regional economics called Creindustrialisation was established. It identified a pool of the most relevant publications on regional economy, confirming the importance of the creative reindustrialisation of cities, including second-tier cities, and assessing the impact of the digital context on cultural transformations. It was revealed that digitalisation of creative industries leads to the convergence of social classes. However, mindless replication of creative practices at the local level reduces their efficiency, hindering the widespread of the creative reindustrialisation tools, requiring further research.
Stakeholder Approach to the Regional Sustainable Development: Empirical Study
Authors:   Perm National Research Polytechnic University, Tretiakova E. A. ,   HSE University Perm, Kurganov M. A. ,   HSE University Perm
Published: September 2023

Introduction of the concept of sustainable development (SD) led to the transformation of values and interests of key stakeholders: the government, population and business. Since consideration of regional stakeholder interests is crucial for ensuring SD of large countries like Russia, a methodology is needed to assess their fulfilment, balance and consistency. However, previous studies of regional sustainable development have not yet proposed such a methodology. The present paper examined and classified regional stakeholder interests and developed an indicator framework to evaluate their fulfilment. We proposed an algorithm for calculating 9 group and 7 integral indices which were subsequently used to measure the socio-economic-environmental balance and inter-stakeholder consistency of interests. The methodology was applied to 17 regions of the Volga and Ural Federal Districts of Russia. The research discovered that sustainable development in most regions was at a medium level. There was no significant difference in the fulfilment of interests among the different stakeholders, which can be interpreted as a factor strengthening social cohesion. Additionally, a socio-economic-environmental imbalance was revealed: the fulfilment of social interests was the highest and that of environmental interests was the lowest. Regression modelling has shown that the presence of this imbalance has a negative impact on SD of Russian regions. The proposed methodology may contribute to broaden the scope of analytical research in the field of sustainable development.
Digital Transformation and its Impact on the Socio-Economic Development of Russian Regions
Authors:   Perm State University, Mirolubova T. V. , Radionova M. V. ,   Perm State University
Published: September 2023

The modern world economy is transforming into the digital economy. Digital transformation can be a driver of socio-economic and technological development of various states and regions. As shown by the experience of developed countries, digital transformation contributes to the creation of new business opportunities, emergence of new markets and niches, and consequently affects regional socio-economic development. However, this process is uneven across countries, leading to significant differences between regions. Additionally, the connection between digital transformation and regional sustainable development should be considered. The paper presents the authors’ perspective on digital transformation and analyses the impact of digital transformation on the socio-economic development of Russian regions in terms of sustainable development priorities. The research aims to develop and verify a multilevel multiple regression model, which illustrates regional digital transformation through integral indicators and describes its impact on regional sustainable development. In particular, the study examined the integral indicator of digital transformation and integral indicator of sustainable development, revealing a correlation between them for Russian regions. The regions were clustered according these indicators. Panel data econometric models for different clusters showed that such factors as digital labour and digital capital greatly influence socio-economic indicators of Russian regions. The direct correlation between the share of manufacturing in gross regional product and regional digital transformation was established. The calculation of integral indicators for all Russian regions identified significant spatial heterogeneity of Russian regions in terms of their sustainable development and digital transformation. At the same time, an increase in the share of manufacturing share in gross regional product causes a decrease in regional sustainable development.
Dyadic Assessment of Perceived Partner Forgiveness and Relationship Investment Model in Turkish Romantic Couples
Authors: EKER DURMUŞ Esra , ÖZBAY Yaşar
Published: September 2023

The aim of this study is to investigate the relationship between perceived partner forgiveness and relationship investment variables [relationship satisfaction, quality of alternatives, investment size,] in dyadic context. The data were collected from 116 heterosexual romantic couples (n = 232) in the 18-30 age group having at least six months of romantic relationship. This study employed cross-sectional correlational study design. Actor-Partner Interdependence Model (APIM) was used to examine the predictive effect of independent variables of the couples on their dependent variables (actor) and their partners’ dependent variables (partner). In this study, dependent variables are relationship satisfaction, quality of alternatives and investment size, independent variable is subjective partner forgiveness. Subjective Partner Forgiveness Scale, The Investment Model Scale were used for data collection. The results suggest that as the level of forgiveness experienced by men and women increase relationship satisfaction increases in the relations between relationship satisfaction and perceived partner forgiveness. Results of the quality of the options and perceived partner forgiveness indicate that the partners' assessment of the quality of alternative decrease as the perceived forgiveness level of both men and women increase. Results of relationship investment and perceived partner forgiveness indicate that the partners' assessment of relationship investment increases as perceived forgiveness in women and men increase. The results were discussed in the context of relevant literature.
SELECTION OF TECHNOLOGICAL PARAMETERS OF MODES FOR MANUAL ARC WELDING OF SHUT-OFF VALVES MADE OF STEEL ALLOYED WITH 3–4 % NICKEL
Authors: Khudyakov A. O. , Shafikov R. T. , Valiakhmetov R. I. , Golik A. V. , Matrosov E. A. , Korobov Yu. S.
Published: September 2023

Body of ball valves can be manufactured from A350-LF3 steel according to the US standard ASTM A350, alloyed with nickel up to 4 %. This steel has a tendency to harden in the heat affected zone during welding. The results of computer simulation showed that cooling rates during shielded metal arc welding exceed the recommended range. This can lead to the formation of hardening structures, the development of cold cracks and a decrease in the performance properties of welded joints of ball valves made of A350-LF3 steel.

To prevent the formation of cold cracks, the preheating and concurrent heating temperatures were calculated. According to the results of computer simulation, it was found that pre-heating and concurrent heating provide the cooling rate of heat affected zone in the recommended range.

The technology has been developed for welding ball valves made of A350-LF3 steel with mounting nozzles. This technology prevents the formation of cold cracks and provides a high level of strength and toughness of welded joints. The high level of mechanical properties of welded joints is confirmed by results of  mechanical tests and metallographic studies.
USE OF SECONDARY ENERGY RESOURCES TO PROVIDE HOT WATER SUPPLY TO BUILDINGS AND CONSTRUCTIONS
Authors: Khabirov Yu. M. , Hamidullin I. S. , Lapshakova I. V.
Published: September 2023

The paper assesses the possibility of using secondary energy resources to provide hot water supply to buildings and constructions. The introduction of recovery systems by using previously unused cheap waste heat energy helps to reduce the amount of energy produced and consumed, increase energy efficiency, and reduce greenhouse gas emissions, which correspond to the development strategy of the construction industry and housing and communal services in the field of environmental protection and energy saving. A method for using the waste heat energy of refrigeration plants to provide hot water supply to an apartment building is proposed. This method makes it possible to ensure uninterrupted supply of hot water to consumers with minimal dependence on the operation of centralized heat supply systems. The minimum power of waste thermal energy sources necessary for the organization of such systems is calculated, and possible sources of secondary energy resources are proposed.
PROBABILISTIC FORECASTING OF THE SERVICE LIFE OF REINFORCED CONCRETE AT ARCTIC OIL AND GAS FACILITIES, CONSIDERING DEFECTS AND DAMAGE
Authors: Fedorov P. A. , Lucyk E. V. , Latypova T. V. , Latypov V. M.
Published: September 2023

Currently, large fuel and energy companies are conducting intensive development of the Arctic territories of the Russian Federation by commissioning new capital construction facilities. At the same time, new formulations of modified concrete with improved performance properties are used. However, in extreme construction conditions, defects and damages can form, which affect the durability of structures. The paper presents the results of probabilistic modeling of the failure-free operation of reinforced concrete according to the criterion of the impact of carbon dioxide on concrete for the conditions of the new shift settlement Sabetta. Concretes with a water-cement ratio of 0.35 and 0.5 on slag-Portland cement were taken as calculated values. The results showed that without defects and damage, the period of normal operation generally corresponds to the design value of 50 and 100 years. If there are defects, the first local areas will appear in 40 years. Recommendations on repair of the considered defects and damages are given.