Clinical and microbiological features and metabolic activity of fecal microorganisms in the rehabilitation of children with post-COVID-19 syndrome
Authors: Feklisova L.V. ,   M.F.Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russian Federation, Zatevalov A.M. , Likhanskaya E.I. , Elezova L.I. , Mekhtiev E.R. , Khadisova M.K. , Shmakov N.A. , Guseva E.N. , Nikolaeva S.V. , Gorelov A.V. ,   G.N.Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation,   G.N.Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation,   Central Clinical Sanatorium "Malakhovka", Federal Medico-Biological Agency of the Russian Federation, Moscow region, Russian Federation,   G.N.Gabrichevsky Moscow Scientific Research Institute of Epidemiology and Microbiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation,   M.F.Vladimirsky Moscow Regional Research Clinical Institute, Moscow, Russian Federation,   Central Clinical Sanatorium "Malakhovka", Federal Medico-Biological Agency of the Russian Federation, Moscow region, Russian Federation,   Central Clinical Sanatorium "Malakhovka", Federal Medico-Biological Agency of the Russian Federation, Moscow region, Russian Federation,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation,   Central Research Institute of Epidemiology, Federal Service for Surveillance on Consumer Rights Protection and Human Wellbeing, Moscow, Russian Federation,   Russian University of Medicine, Moscow, Russian Federation
Published: July 2024

The significant occurrence of a cohort of children who do not achieve complete recovery after the acute period of coronavirus infection has drawn the attention of researchers to elucidate the etiopathogenetic reasons for the lack of process termination. Objective. To study clinical-anamnestic and microbiologic parameters of fecal samples as possible predictors of the prolongation of the post-COVID state on the basis of laboratory tests performed at admission to the sanatorium at different time periods after COVID-19 infection. Patients and methods. In 61 children aged 4 to 17 years, a comprehensive clinical and laboratory investigation was performed in the rehabilitation of the post-COVID-19 condition. Results. The main complaints on admission: rapid fatigability, decreased appetite, decreased tolerance of habitual physical and mental exertion, tendency to constipation, increased frequency of episodes of acute respiratory diseases. In the microbiota of fecal excretions the reduced level of high-grade Escherichia coli, bifido- and lactobacilli was established. Inhibition of functional activity of microbiota was noted. Abnormal amount of fatty components was detected at scatoscopy. General health-improving measures promoted clinical and laboratory recovery processes. Conclusion. Commonly accepted recreational sanatorium activities contribute to the rehabilitation of children with post-COVID condition and can be recommended as a mandatory program. Key words: children, microbiota, post-COVID-19 syndrome, rehabilitation