bluuebunny/crossref_metadata_2025 huggingface dataset:
The Angiotensin-Converting Enzyme Genotype and Microalbuminuria in Autosomal Dominant Polycystic Kidney Disease
Authors: VAN DIJK MARJAN A. , PETERS DORIEN J.M. , BREUNING MARTIJN H. , CHANG PETER C.
Published: April 2021

Autosomal dominant polycystic kidney disease (ADPKD) has a variable clinical course. Clinical parameters associated with a worse prognosis are hypertension and proteinuria or microalbuminuria (MA). Because chronic stimulation of the renin-angiotensin system is likely to be present in ADPKD patients, the effect of the angiotensin-converting enzyme insertion/deletion (ACE I/D) genotype on the variability of these clinical parameters was examined in untreated ADPKD patients. Proteinuria and MA were determined in 24-h urine collections. BP measurements were performed with an ambulatory monitor, over 24 h. With analysis of covariance, the ACE genotype was found to be significantly associated with MA, corrected for age, gender, GFR, mean arterial pressure, body surface area, and urinary Na+ excretion (P < 0.05). The patients homozygous for the deletion (DD) had the highest rate of MA (P < 0.05) compared to the patients homozygous for the insertion (II). There was no relationship between the ACE genotype and BP or renal function. A significant positive correlation was found between MA and mean arterial pressure (r = 0.31, P < 0.05), whereas a significant negative correlation was found between MA and renal function (r = -0.28, P < 0.05). In conclusion, in ADPKD patients, MA is partly determined by the ACE I/D polymorphism. Because MA is associated with an enhanced progression toward renal failure, the ACE genotype could help in identifying patients at risk for a worse prognosis.
Mycophenolate Mofetil Does Not Modify the Incidence of Cytomegalovirus (CMV) Disease after Kidney Transplantation but Prevents CMV-Induced Chronic Graft Dysfunction
Authors: GIRAL MAGALI , NGUYEN JEAN MICHEL , DAGUIN PASCAL , HOURMANT MARYVONNE , CANTAROVICH DIEGO , DANTAL JACQUES , BLANCHO GILLES , JOSIEN REGIS , ANCELET DARIA , SOULILLOU JEAN PAUL
Published: April 2021

Ganciclovir, which is used to treat cytomegalovirus (CMV) infection, has been shown in rodent models to abolish CMV-mediated chronic cellular damage and endothelial cell proliferation; when associated with mycophenolate mofetil (MMF), it has been shown to increase its anti—herpes virus activity. This study tested the hypothesis that kidney graft recipients who received antirejection prophylaxis with MMF and who were treated with ganciclovir for a declared CMV disease could be protected from chronic graft dysfunction. Investigated was the impact of ganciclovir-treated CMV diseases in consecutive first kidney recipients according to their immunosuppressive therapy. The azathioprine (Aza)-treated group (Aza group) included 319 patients. The MMF-treated group (MMF group) included 126 patients. CMV disease was clinically defined and confirmed by virological proof of CMV infection and was treated for at least 14 d with ganciclovir. Despite having the same incidence (21.6% in the Aza group versus 24.6% in the MMF group) and severity, CMV disease was significantly associated with graft loss independent of acute rejection episodes or other factors when tested in a Cox proportional model in the Aza group only (P < 10-4). It was shown for the first time that patients whose CMV disease is treated with ganciclovir while they are on MMF therapy are protected from the long-term deleterious consequences of CMV disease on graft survival, independent of acute rejection. It is suggested that the enhanced anti—herpes virus activity of ganciclovir by MMF could contribute to this reported effect, which may represent a significant contribution of MMF efficacy to graft survival.
Türkiye’de Yayımlanmış Resimli Çocuk Kitapları Üzerine Kültürel Bir Analiz
Authors: DEDEOĞLU Hakan , İNCE Nuri Barış , ULUSOY ÜNLÜ Ayşenur
Published: April 2021

Çocuk edebiyatı ve kültür ilişkisi uluslararası literatürde geniş bir yelpazede ele alınmasına karşın ülkemizdeki akademik çalışmaların ve çocuk kitapları yayıncılığının oldukça sınırlı düzeyde kaldığı görülmektedir. Bu çalışmada Türkiye’de yayımlanmış resimli çocuk kitapları seçkisinin Türk kültürünü yansıtma düzeyini incelemek amaçlanmıştır. Araştırmada yazarlar tarafından amaçlı örnekleme yöntemlerinden biri olan ölçüt örnekleme yöntemiyle oluşturulan 15 kitaplık bir resimli çocuk kitabı seçkisi değerlendirmeye alınmıştır. Bu amaçla, seçilen kitaplardaki olayların geçtiği yerler (topoğrafya, iklim, doğal kaynak, konut/işyeri); kitaplardaki karakterler (toplumsal ilişkiler, ekonomik ve politik temsiller) ve seçilen kitaplardaki ele alınan temalar (toplumsal ilişkiler, ekonomik ve politik temsiller) Türk kültürünü yansıtma düzeyi açısından incelenmiştir. Bulgular genel olarak değerlendirildiğinde kültürel temsillerin kıyafet, yemek, konut/işyeri tasvirleri ve geleneksel cinsiyet rolleri gibi yüzeysel kültürel sembollerle ağırlıklı olarak ilişkilendirildiği görülmektedir.
iDISCO protocol for whole-mount immunostaining and volume imaging v1
Authors: Huesing Clara , Muenzberg Heike , Burk David , Torres Hayden
Published: April 2021

Protocol documents how to dehydrate, immunolabel, and clear tissue in preparation for light sheet microscopy.
The Role of the ‘Cities for Change’ in Protecting the Rights of Irregular Migrants in Spain
Authors: Fernández-Suárez Belén , Espiñeira Keina
Published: April 2021

Have the new municipalist pro-migrant policies succeeded in protecting the rights of irregular migrants? Cities in Spain have powers to design and implement services and programs aimed at the reception and integration of immigrants. Cities can also include those who are in vulnerable conditions, guaranteeing them access to healthcare, minimum income coverage or labour training, regardless of the immigration status. However, old municipal politics have been characterised by pragmatism, being mainly focused on regular immigrants. Besides, there has been a restrictive and punitive turn in immigration policy directly connected to the economic recession and austerity as of 2008. To explore what possibilities do cities have to expand and protect the rights of irregular immigrants, we analyse in this contribution the cases of Madrid and Barcelona for the years 2015–2019 when progressive municipalists fronts ruled the cities. Based on the textual analysis of policy documents and in-depth interviews with political parties, street-level bureaucrats and activists, we first examine the competencies that municipalities have in migration matters and mainstream approaches in Spain. Then we discuss the action of the new municipalism, focusing the analysis on four political measures that have been rebel and innovative in protecting irregular immigrants, namely, the proactive census, the prevention of irregularity, access to healthcare and changes in police protocols. These real experiences allow us to argue that cities can achieve changes in the way state control is enforced. However, the analysis also shows tensions between the political will and institutional constraints.
Analysis of garden snail (Helix aspersa Muller) mucus for the presence of potential effectors of hemostasis system
Authors: Kyriachenko Y. , Halenova T. , Savchuk O.
Published: April 2021

Today, there are many approaches to new drugs development, but none of them can replace the important role of natural products in the discovery and development of drugs. Natural raw materials remain an extremely important source of medicines. A number of biologically active molecules of natural origin have already found a direct medicinal use, while many others can serve as chemical models or templates for the design and synthesis of new pharmaceutical agents. Snail mucus has been attracting the attention of scientists for many years as a source of natural biologically active substances. The components of snail mucus have been repeatedly tested for antimicrobial, antioxidant, anti-inflammatory and anti-cancer activities. In this work, the biological effects of components of the mucus of the garden snail Helix aspersa, distributed in Ukraine, were studied. The research results proved the
presence of protein molecules, some of which had a pronounced proteolytic potential with specificity for gelatin, collagen and fibrinogen. When mucus was added to blood plasma, its components initiated the formation of active thrombin, and also prolonged the clotting time of plasma in the coagulation test APTT. In addition, the components of H. aspersa mucus enhanced the effect of platelet aggregation inducer and inhibited their disaggregation. It was proved that the components of H. aspersa mucus had no cytotoxic effect. The obtained results indicate the prospects and importance of further experiments on the study of mucus protein fractions in order to identify individual biologically active molecules responsible for the manifestation of these effects. A detailed analysis of the composition and study of the properties of snail mucus will serve as a basis for obtaining potentially new substances with targeted activities and their further use in various industries, including pharmaceutical.
Analysis of functional changes under using of candesartan cilexetil with resveratrol in animals
Authors: Beliayeva A. , Garmanchuk L.
Published: April 2021

Cardiovascular diseases are widespread throughout the world. The incidence of diseases of the cardiovascular system has increased several times. Cardiovascular diseases have become the leading cause of death in many countries. Currently, the efforts of many researchers are aimed at studying and creating new, more effective and safe drugs and their combinations for the treatment of pathology of the cardiovascular system. Candesartan cilexetil is an angiotensin II receptor antagonist. It is used medicinally as a long-acting antihypertensive agent. However, this drug has a number of side effects. Resveratrol is a natural antioxidant. This substance exhibits pleiotropic effects, including antioxidant, anti-inflammatory, anti-aging, cardioprotective, and neuroprotective activities. The aim is investigation of acute toxicity of candesartan cilexetil and resveratrol in combination in vivo. Male and female ICR mice were used for the experiment. Animals received candesartan cilexetil and resveratrol intragastrically once. Evaluation of
the effects of substances on internal organs (heart, spleen, kidneys, lungs, liver and brain) was carried out in 2 weeks after the introduction of the substances. It was shown that candesartan cilexetil with natural resveratrol did not lead to functional changes. There were no changes of behavior during the observation period. The combination of candesartan cilexetil with resveratrol did not lead to the death of mice, therefore the mean lethal dose (LD50) was not determined. The new combination of substances was safe. No side effects have been reported. The combination of candesartan cilexetil with resveratrol is non-toxic, and the use of these substances is safe for animals.
Morphological characteristics pf Heifei saffron (Crocus heuffelianus Herb.) in the Podilsky Tovtry national nature park
Authors: Odukalets I. , Tsymbaljuk D. , Grigorchuk A.
Published: April 2021

The article performs the results of the study of morphological parameters of individuals of the population of Crocus heuffelianus Herb on the territory of the nature reserve fund in the conditions of the Podilski Tovtry National Nature Park. The aim of our research was to study the morphometric parameters of Crocus heuffelianus to establish the adaptive capacity of the species in the study area. The morphometry of 50 generative individuals of Crocus heuffelianus growing in the 10th quarter of the Chemerivtsi environmental scientific-research department was performed.The general characteristic of the dynamics of vegetative cover on the investigated territory is representes basing on the conducted geobotanical descriptions of phytocenoses with the participation of Crocus heuffelianus Herb. Crocus heufellianus grows within 10 quarters in the forest crops Quercus robur L. (twenty-five years old), plantations of Pinus sylvestris L. (forty years old) and in the area with the group of QUERCO-FAGETEA BR.-BL. ET VLIEGER 1937, Fagetalia sylvaticae Pawі. 1928, Carpinion betuli Issler 1931 em. Mayer 1937 where eighty-year-old Carpinus betulus L., Quercus robur L. predominate. The analysis of measurements was carried out in the studied population of the species: plant height together with inflorescence; length and width of leaves. According to the results of our study, it has been found out that the height of plants in the population ranged from 7.6 cm to 14 cm. On average, this figure was 10.3 ± 2.0 cm. The size of the leaves of the predominant number of individuals in the population was characterized by the following anatomical and morphological parameters: width – 0.2-0.7 cm, length – 4.9-10.7 cm. It is shown that the vast majority of individuals of the species have one flower. Crocus heuffelianus has some variability of morphological features in the studied population. This indicates a significant potential for the species to grow in different environmental conditions, which can not be realized under conditions of increased anthropogenic pressure. The unique plain localities of this Montana-Alpine species on the territory of the Podilski Tovtry National Nature Park have a high sozological and scientific significance and require systematic, long-term monitoring.
Effect of modulation of hydrogen sulfur and glutathione synthesis on oxidative and nitrosative metabolism under myocardial ischemia-reperfusion
Authors: Fedichkina R. , Korkach Yu. , Okhai I. , Goshovska Yu. , Sagach V.
Published: April 2021

Redox balance maintaining is a prerequisite for normal cardiomyocytes metabolism. Reperfusion injury of the heart is characterized by an explosive increase in ROS generation, cell membranes damage, dysfunction of proteins, the development of muscle contracture etc. It was shown that the hydrogen sulfide (H2S) and the precursor of its synthesis the amino acid L-cysteine provided cardioprotective effect against ischemiareperfusion, In addition, L-cysteine is one of amino acids that form an antioxidant glutathione (GSH). The aim of our work was to investigate the effect of GSH and H2S synthesis modulation on the oxidative and nitrosative stress in cardiac tissues under conditions of ischemia-reperfusion. The H2S synthesis inhibitor propargylglycine (PAG), the GSH synthesis inhibitor butionine sulfoxime (BSO) and L-cysteine were administered intraperitoneally. Next, ischemia-reperfusion of the Langendorff isolated rat heart was performed. In the tissues of rat's hearts, before and after ischemia, we determined the rate of ROS generation, content of POL products, the activity of NO synthesizing enzymes. Results of our study showed that pretreatment with PAG + L-cysteine combination prevented heart function disturbances, ROS formation, increased low molecular weight nitrosothiols content, preserved the activity of constitutive NOS and inhibited the activity of inducible NOS in the pre-ischemic period as well as in the period of reperfusion. Pretreatment with BSO in PAG + L-cysteine group significantly reduced the effectiveness of the combination and abolished cardioprotective effect. Generation of superoxide and hydroxyl anions was increased, activity of inducible NO-synthase was 3.5-fold increased comparing with PAG + L-cysteine pretreated group. Pretreatment with PAG + L-cysteine combination inhibited the formation of ROS and preserved the activity of constitutive NOS, thus providing stable production of NO. Pretreatment with BSO completely abolished an antioxidant effect of PAG + L-cysteine decreasing bioavailability of glutathione.
Manganese encephalopathy and interhemispheric asymmetry of the brain
Authors: Berezovchuk L. , Makarchuk M.
Published: April 2021

Patients suffering from manganese encephalopathy, which develops while taking surrogate drugs, suffer from pronounced subcortical pseudobulbar syndrome, pyramidal insufficiency and a complex of autonomic disorders. The most pronounced of them are disorders of motor functions. The work is devoted to the study of the bioelectrical activity of the brain of patients with manganese encephalopathy in order to develop an EEG-criterion for diagnosing this disease. The subjects underwent EEG recording using a 16-channel electroencephalograph "NeuroCom standart" (KhAI-Medika, Ukraine) in accordance with the international recording system "10-20". The following were analyzed: the power of the signals of the main rhythms of the background EEG, the relative characteristics of the power of the signals of the main EEG rhythms – the activation coefficient of the cortex, the activation coefficient of the sub cortex, the indices of interhemispheric asymmetries in terms of the power of bioelectric signals in bilaterally synchronous points of the head. It was found that in patients with manganese encephalopathy both the cortical activation coefficients and the sub cortex activation coefficients had values that can be observed in patients with аnother diseases. In turn, such indicators as interhemispheric
asymmetry in the power of signals of individual rhythms and interhemispheric asymmetry in the total power of signals at bilaterally synchronous points of the head in patients with manganese encephalopathy had values that significantly differed from those in patients with other types of pathology. So, with indicators of 16-18 interhemispheric asymmetries in healthy people and 9-25 in patients in coma, in patients with manganese encephalopathy, it was observed: in one patient – 12 interhemispheric asymmetries, in the other of the patients – 9, 7, 3 and 2 interhemispheric asymmetries in signal power of individual rhythms at bilaterally synchronous points of the head. The reason for such a pronounced smoothing of interhemispheric asymmetries in patients with manganese encephalopathy, obviously, may be those destructive changes in the subcortical parts of the GM that are present in this group of patients.
Desarrollo local y post-productivismo en territorios periféricos. Los olivares patrimoniales de Almería (SE de España) / Local development and post-productivism in peripheral territories. The heritage olive groves in Almeria (SE Spain)
Authors: Sánchez Escolano Luis Miguel , Ruiz Moya Noelia
Published: April 2021

Las áreas rurales periféricas mediterráneas, marcadas por una profunda descapitalización humana y económica, y con una débil presencia en los relatos que gobiernan la cultura de masas globalizada, encaran el siglo XXI con perspectivas precarias sobre su viabilidad productiva y, en ocasiones, sobre la pervivencia misma de sus estructuras territoriales. Las actividades agrarias tradicionales de estos espacios, debido a la pérdida de su histórica posición comercial, se han visto abocadas progresivamente a escenarios definidos por la desatención, incluso el abandono, si bien en ciertas ocasiones han apostado por la recreación de sus valores enfocada al ocio de las poblaciones urbanas, quedando, en consecuencia, cada vez más desvinculadas de la producción. La presente investigación, a través de la implementación de las estrategias y herramientas que propugna el paradigma del desarrollo endógeno y local, reconoce, analiza y sistematiza los valores patrimoniales de los olivares históricos de la provincia de Almería (Andalucía, España). Éstos, a través de un replanteamiento de su papel en las comunidades rurales en que se insertan, y revelando a la ciudadanía su exacta dimensión ecológica, cultural o paisajística, pueden erigirse en herramientas para la dinamización económica y social del territorio rural en el contexto post-productivista imperante; impulsando, asimismo, procesos de desarrollo sostenible, y ofreciendo, en definitiva, una oportunidad para la mejora de los estándares de calidad de vida de los habitantes de ese entorno.
El milagro y lo cotidiano: interiores domésticos y mobiliario popular en los exvotos andaluces
Authors: Fernández Martín Mª Mercedes
Published: April 2021

A través de la abundante presencia de exvotos pintados en Andalucía occidental se analizan diferentes aspectos de la vida cotidiana como el mobiliario y la presencia que éste tiene en la vivienda, como reflejo de la pertenencia social de sus propietarios. Obras en su mayor parte de autores anónimos y pintores no profesionales, la sencillez e ingenuidad de las pinturas contrasta con la gran cantidad de información que proporcionan. A diferencia del mueble culto, el popular evolucionó más lentamente, pudiéndose afirmar en muchas ocasiones que nos encontramos ante muebles de época indeterminada. De acuerdo con su clasificación cronológica podemos seguir la evolución de sus estructuras y tipologías, así como el cambio de gusto que repercutirá en los temas ornamentales y en la técnica, apreciándose la influencia del mueble culto sobre el popular, o la unión frecuente de ambas expresiones artísticas.
Two pedestal Tables by Jean-Charles-François Leloy in the Royal Collections of Patrimonio Nacional
Authors: Mateos Martín Mario
Published: April 2021

The aim of this paper is to provide an in-depth information of two pedestal tables (named Table du Sacre  and Guéridon Mauresque) designed by Leloy, and kept in the royal collections of Patrimonio Nacional (National Heritage).

Despite their differences, they both have some elements in common: not only Sèvres porcelain was used as their main decorative material offering painted historical scenes, but also both of them were gifts from French sovereigns to Spanish monarchs. The two pieces were also displayed in the 19th century at the Louvre Royale Manufactures Exhibitions as an example of the high quality that the Sèvres Manufacture achived.

Although the Table du Sacre (table of coronation due to its iconography) is of great interest, the decoration of the Guéridon Mauresque is specially remarkable as it provides an interesting insight between courts. It depicts Boabdil leaving the Alhambra, being directly inspired by the Nasrid Palace (15th century): a piece of furniture depicting a scene of the Spanish Moorish past, was made in France and later offered as a gift to the regent of the Spanish Kingdom María Cristina de Borbón.
Forma en movimiento: mecedoras valencianas de madera curvada.
Authors: Vives Chillida Julio Andrés
Published: April 2021

El objetivo del artículo es presentar visualmente un conjunto representativo de mecedoras de madera curvada fabricadas en Valencia entre 1900 y 1936. Tras la referencia a su origen en la empresa de Hermanos Thonet y su fabricación en Austria-Hungría, se examina la recepción de las mecedoras en Valencia y los diversos tipos y estilos de las piezas que se producían: con espiral, con aros, con lateral continuo, modernas, abarrocadas e infantiles. En algunos casos algunas mecedoras pueden calificarse como modernistas por sus formas.
Miguel Fisac and St. Peter Martyr Theological Center
Authors: Díaz del Campo Martín-Mantero Ramón Vicente
Published: April 2021

The fifties were important in Spain for the creation of a modern architecture. The architects, who began working in previous years, created his artistic languages inspired in modern styles. Miguel Fisac was one of the most popular Spanish architects in the second half of the twentieth century. In 1954 he received a request from the Dominican Order to design a theological centre for the youngest members. In view of the particular circumstances surrounding this case, the architect had many preparatory documents (sketches, memories, plans ...) and currently housed in the Miguel Fisac’s documentary archives and Foundation. Everything was done following Fisac’s drawings. In February 1958, Fisac carried out some furniture projects for the building while directing its construction. He wrote some documents where he explicitly detailed the place of each piece of furniture in each space.
Muebles y decorados de cine: Luis M. Feduchi, Luis Santamaría y su contribución a la película "El bailarín y el trabajador" (1936)
Authors: Muñoz Fernández Francisco Javier
Published: April 2021

Luis M. Feduchi y Luis Santamaría se encargaron de los decorados y el mobiliario de la comedia-musical de inspiración hollywoodiense “El bailarín y el trabajador” que Luis Marquina dirigió en 1936. Se trató de diseños realizados por los propios decoradores, que también utilizaron muebles de José Manuel Aizpúrua y su colaborador Joaquín Labayen, así como sillas inspiradas en la casa Thonet. El filme se rodó, principalmente, en platós de cine por lo que el mobiliario fue el principal elemento para su ambientación; a la vez que le dotaron de un carácter moderno y dinámico, poco habitual en el cine español de la época, pero acorde con el carácter de la película.
Pasión por lo sintético. El mobiliario pop en la Barcelona del "desarrollismo", 1960-1975
Authors: Mellado Lluch Maria Pilar , Campi Valls Isabel
Published: April 2021

Este trabajo es la continuación de la investigación que iniciamos hace dos años sobre los objetos de plástico en la Barcelona del “desarrollismo”. En esta ocasión nos hemos centrado más en la relación entre el pop-art catalán y los muebles de plástico, en la cultura del ocio entendida, según las teorías de Lees-Maffei, como un conjunto de mediadores y en el análisis de los muebles de poliéster, los únicos que han llegado hasta nuestros días. El mueble pop constituyó un auténtico desafío a los parámetros del Good Design que en adelante encontrarían una fuerte oposición por parte de los diseñadores más jóvenes.
Una lectura de Rayuela desde el Fantasma de la Maga = A Reading of Rayuela from Maga’s Ghost
Authors: Plaza Morales Natalia
Published: April 2021

En el presente trabajo llevamos a cabo una lectura de Rayuela, con el propósito de profundizar en aquellosaspectos de estilo que nos resultan pertinentes en cuanto a la relación que mana entre los personajes de Horacio Oliveira y de La Maga en esta novela. En este sentido, pretendemos elucidar la caracterización de estos dos personajes por medio de la neutralidad como modo de lectura para comprender el juego narrativo cortazariano y reforzar la idea de una búsqueda de ruptura dicotómica en la narrativa del escritor argentino. El vínculo de Oliveira con las mujeres nos llevará a la lectura del goce como estadoperseguido por el personaje.In the present work we carry out a reading of Rayuela, with the purpose of deepening into those aspects of style which are relevant to us with respect to the relationship that springs between the characters of Horacio Oliveira and La Maga. In this sense, we intend to elucidate the portrayal of these two characters through neutrality as a reading hypothesis, in order to understand the narrative of Cortázar and reinforce the idea of a search for a dichotomous rupture in the narrative of the Argentine writer. Oliveira’s bond with women will lead us to the reading of enjoyment as a state pursued by the character.
Olivante de Laura y la reflexión sobre el vestido = Reflections upon clothing in Olivante de Laura
Authors: Pastrana Santamarta Tomasa Pilar
Published: April 2021

Antonio de Torquemada nos ofrece en su obra Olivante de Laura las alusiones a prendas propias de los libros de caballerías; sin embargo, aporta una novedad frente a otras de su género pues la trama cuestiona la validez del vestido como elemento marcador de jerarquía. La noción medieval de «cada uno según su estado» se convierte así en objeto de debate por parte de los propios personajes. El héroe viste con ropas no acordes con su estatus para poder acercarse a su amada, al igual que hacían las gentes dela época para poder conseguir sus fines. A partir de este hecho, Torquemada muestra sutilmente los cambios que la sociedad está sufriendo y cómo se hace necesario establecer en vez del vestido, otro elemento más eficaz que pueda representar las jerarquías sociales, como pudiera ser el linaje o la sangre.Antonio de Torquemada displays in Olivante de Laura the typical references to clothing and textiles used in other chivalric books. However, he innovates as he questions the capacity for dress to convey hierarchy. The medieval notion of dressing «according to one´s status» becomes now the central topic for debate about which the main characters discuss. Following the Renaissance trend, the hero disguiseshimself as a shepherd in order to approach his loved one. His behavior is a reflection of the times, when people also wear clothes not appropriate to their status. It is from here that Torquemada subtly shows the way society is changing and claims for a new and more effective method to determine and measure hierarchy. Clothing will no longer be valid, he then proposes linage.
ELSA MARGARITA RAMÍREZ LEYVA (coord.) La enseñanza de la lectura en la universidad, México DF, UNAM, 2017, pp. 216.
Authors: Dominguez Mariana
Published: April 2021

El presente texto reseña el libro La enseñanza de la lectura en la universidad (2017), coordinado por la Doctora y Bibliotecóloga Elsa Ramírez Leyva y surgido a partir del Seminario “La enseñanza de la lectura en la universidad”, realizado en 2015 y organizado bajo los auspicios de la Red Internacional de Universidades Lectoras, el Instituto de Investigaciones Bibliotecológicas y de la Información de la UNAM, y el Instituto de comunicación de la Universidad Panamericana, Escuela de Comunicación, campus Ciudad de México. El volumen reúne diversas investigaciones sobre la lectura en distintas universidades de México y España.
JUAN ANTONIO GALLARDO, Después del invierno (Cuadernos), Sevilla, Ediciones En huida, 2018, 181 pp.
Authors: Balcells José María
Published: April 2021

Reseña de JUAN ANTONIO GALLARDO, Después del invierno (Cuadernos), Sevilla, EdicionesEn huida, 2018, 181 pp.
CONCEPCIÓN VALVERDE, El último fado, Córdoba, Almuzara, 2018, 238 pp.
Authors: Balcells José María
Published: April 2021

Reseña deCONCEPCIÓN VALVERDE, El último fado, Córdoba, Almuzara, 2018, 238 pp.
SANTIAGO MONTOBBIO, Poesía en Roma, Alhaurín el Grande, El Bardo, 2018, 542 pp.
Authors: Balcells José María
Published: April 2021

Reseña de SANTIAGO MONTOBBIO, Poesía en Roma, Alhaurín el Grande, El Bardo, 2018,542 pp.
ANTONIO CHAS AGUIÓN (ed.), Escritura y reescrituras en el entorno literario del «Cancionero de Baena», Berlín, Peter Lang, 2018, 252 pp.
Authors: Trincado Sabín María Cristina
Published: April 2021

Reseña de ANTONIO CHAS AGUIÓN (ed.), Escritura y reescrituras en el entorno literariodel «Cancionero de Baena», Berlín, Peter Lang, 2018, 252 pp.
Portada del número 14 (2019). Imagen de Yolanda Castaño.
Authors: Cuesta Torre María Luzdivina
Published: April 2021

Motivo cubierta. Autora: Yolanda Castaño Pérez. "Joarilla de las Matas, León, en fotografía de Valentín Costó". Óleo sobrelienzo. 73x54 cm. Año 2018.
Teresa de Ávila y la poesía cancioneril = Teresa de Ávila and the songbook poetry
Authors: López de Castro Armando
Published: April 2021

Teresa de Jesús escribió poesía porque tenía un alma musical y sabía dar ritmo a sus poemas. Es una música que surge de la oscuridad y habla de lo profundo, destinada a elevarse desde la fuerza de su dolorosa espera, de ahí que invite a la plegaria con el estremecimiento de ser sustancia viva. Vueltos hacia su propio interior, sus poemas potencian su energía sonora desde la desnudez de su fingida retórica y nos hacen volar el oído hacia lo sobrenatural, buscando la recuperación del orden perdido. Teresa de Jesús wroter poetry because she had a musical soul and knew how to give rhythm to her poems. It is a music that emerges from the darkness and speaks from the deep, destined to rise from the force of its painful waiting, hence the invitation to prayer with the shudder of being living substance. Turned towards his own interior, his poems enhance his sound energy from the nakedness of his feigned rhetoric and make us blow our ears towards the supernatural, seeking the recovery of the lost order.
Mario Paz González. Ángel Fernández Fernández, La huerta de los manzanos. Madrid, Visor Libros, 2019, 74 p.
Authors: Paz González Mario
Published: April 2021

Reseña literaria
Gender Qualities and Roles of Villains: Presented in North-American Web Comic Homestuck by Andrew Hussie
Authors:   Tsukuba University, Japan, Ilina Olga
Published: April 2021

In this article, using the popular North American comic Homestuck by Andrew Hussie (2009-2016), we look at the roles assigned to various antagonistic characters based on their gender. In the 21st century, the world has become more complicated and has ceased to be divided into black and white, absolute good and absolute evil. Literature and popular culture have become more complex, and with it the image of the antagonist has changed, the antagonist has ceased to be just a villain who does evil just because this is his role in the story. The idea of non-binary gender situations, when the usual traditional stereotypes could not describe reality, appeared. A revision of the traditionally masculine and feminine qualities took place, and feminine softness, diplomacy, and compliance began to be viewed not as a weakness, but as a privilege. At the same time, traditionally masculine qualities such as aggressiveness, self-confidence, and intransigence are no longer viewed exclusively in a positive way. This article discusses what the image of modern villains is and how their villainous role relates to their gender qualities.
Final year medical students versus interns: information seeking behaviour about COVID-19 therapy in India
Authors: David Rosme , George Deepthi Mary , Chandra Shalini , Marwaha Vishal , Palatty Princy Louis
Published: April 2021

Background: Doctors alone must be capable of taking ultimate responsibilities for making decisions in clinical uncertainties. A right clinical judgement and management was the ultimate priority for health care workers during the COVID-19 pandemic. The objective of our study was to access knowledge about COVID-19 treatment among the final year bachelor of medicine and bachelor of surgery (MBBS) students and interns and thereby to understand the information seeking behaviour.Methods: Multicentric cross-sectional questionnaire-based study among the final year MBBS students and interns. The google form questionnaire was sent to the participants through whatsapp or mail. The questions were related to the drugs, the precautionary measures and the dead body disposal in COVID-19. Attitude regarding seeking information about the new disease, updated treatment guidelines as well as the preferred resource materials was also studied. The sample size was calculated based on a pilot study.Results: Out of 316 participants, 30.7% had good, 53.2% had adequate and 16.1% had inadequate knowledge regarding the updated treatment guidelines.  In one of the questions about hydroxychloroquine, 51.5% final year MBBS students (n=200) and 63.8% interns (n=116) responded correctly (p<0.034). 65.4% gathered information by self-directed learning through various sources. 45.8% gathered information from social media while 44.4% read printed materials and 39.3% heard online/offline lectures.Conclusions: We conclude that the final year MBBS students and interns have satisfactory knowledge about COVID-19 treatment. Interns had better awareness than the final year MBBS students. Retaining the theoretical knowledge during internship will make the young doctors more confident while practicing.
Coronary artery disease prescribing pattern and risk factor assessment in the patients undergoing angioplasty
Authors: Solanki Nilay D. , Patel Nisha , Desai Shubha , Patel Varsha
Published: April 2021

Background: Coronary artery disease is caused by an obstruction in vascular supply to the heart. Angioplasty is a frequently used intervention for the management of CAD patients. Supportive and preventive therapies are additionally provided to these patients. Objective of current study was to assess the associated risk factors as well as prescribing trends in CAD patients.Methods: A prospective study was conducted in 88 patients undergoing coronary angioplasty. Patients were assessed for risk factors of CAD. Medication history of patients was recorded in case record form for analysis of prescribing trend and its rationality. Data were statistically analyzed using prism software.Results: In present study most of the CAD patients were male (80.68%) and mean age of patient was 59.19 years. Majority of patients (39.77%) were in age range of 61-70 years. Most common associated conditions at admission were hypertension and diabetes. In this study, BMI, stress, lack of exercise, hypertension, diabetes, family history of CVD were risk factors of CAD and significant correlation observed with risk factors and coronary artery disease. (p<0.05) Frequently prescribed drugs were antiplatelet, antibiotics, antihypertensive, antiulcer, antihyperlipidemic, antidiabetic agents. In 19.31% cases, drug interaction was detected out of which two cases recorded severe. Medical stents coated with everolimus, sirolimus were also prescribed.Conclusions: It was concluded that history of cardiovascular disease, hypertension, diabetes are major risk factors of CAD. Certain level of irrationality in the prescribing trend was observed. Proper patient counselling and care can help in preventing CAD and reduces health burden.
Self medication among elderly poses challenges in urban settings
Authors: Hingorani Sadhana K. , Desai Anupama S. , Desai Sakshi S. , Bansal Raj Kumar , Agarwal Shubham , Solanki Naisargee , Desai Ishaan
Published: April 2021

Background: Self-medication can be defined as obtaining and consuming one (or more) drug(s) without the advice of a physician. Using over the counter medicine is a common practice in developing countries including India. Studies have shown relatively high rates of self-medication among elderly and suggested awareness programmes among this group. Objectives of current study are to determine the prevalence of self-medication among geriatric population and to educate them about self-medication by an interactive session.Methods This was a cross sectional, questionnaire based study to evaluate the prevalence of self-medication in geriatric population in senior citizen club of Adajan and Ghoddod area of Surat city. Questionnaires were designed and modified from previous studies. Written informed consent was taken from those willing to participate in the study. After filling of pre-questionnaire, an interactive session was arranged and post-questionnaire were given to all participants. Data obtained were subjected to statistical analysis.Results: Number of participants in present study was 100. Self-medication was most common in age group of 65 to 75 years (48%) followed by less than 65 years (33%). 85% participants reported having taken non-prescription drugs. Drugs commonly used for self-medication were analgesics (85) and antacids (80). Side effects due to self-medication were reported by 22 participants. Main reasons for self-medication cited were to save expenses (65) and to save time (62). Post study awareness increased to 98%.Conclusions: Prevalence of self-medication is high in elderly. Interactive session can increase awareness regarding self-medication.
Licofelone in osteoarthritis: is this the awaited drug? a systematic review
Authors: P. Vinod Kumar
Published: April 2021

Osteoarthritis is a progressive joint disease associated with aging in elderly is, characterized by pain, inflammation, and difficulty in movement. The pathways involved in the progression of this disease remain unclear. The mediators, eicosanoids and leukotrienes are produced by COX-1/COX-2 or 5-LOX. Physicians have always used nonsteroidal anti-inflammatory drugs to treat the pain associated with osteoarthritis. A competitive inhibitor of LOX-5 and COX-2 that has both analgesic and anti-inflammatory activity is licofelone; one of the most promising candidates for the treatment of osteoarthritis is under clinical trial in treatment. A significant reduction in cartilage volume was displayed. A significant improvement over baseline on the WOMAC index and GI tolerance was also observed. Improving the symptoms related pain sensation with a happier life. With new strategies in OA, new methods to target pain, inflammation and movement restrictions would be the ultimate goal in patient satisfaction for the future. Licofelone was found to be effective compared to NSAIDs or coxibs in the treatment of OA. Does this mean this could be the answer?
Therapeutic potential of seaweeds
Authors: Goel Rajeev , Saini Tushar , Mahendru Binny
Published: April 2021

Seaweeds in general are known to contribute to the maintenance of health through their nutritional and medicinal properties and are served in soups and salads, cooked with grains, legumes or miso-soup broth, vegetable pies, stews and even consumed dried. The medicinal properties of seaweeds or vegetables have long been known in many cultures of people particularly those living in the coastal regions who are consuming these from centuries. Traditional Chinese dietotherapy (TCD) makes good use of natural marine nutrients and food to preserve health. Koreans wrap their bodies in seaweeds to get rid of deadly body toxins and Japanese who eat large quantities of seaweeds have very low incidence of cancers. The compounds with diverse biological activities such as antioxidant, antiviral, antifungal, antineoplastic, antimicrobial etc. have been isolated from the flora in the sea. A score of these bio-medicinal compounds are in different stages of clinical trials & analysis and are the focus of this article.
Microbiological profile and antibiotic resistance pattern of urinary tract infection in a tertiary care hospital
Authors: R. Vismaya V. , Shajihan Naiema , Ramesh Midhun , Devi Ambika
Published: April 2021

Urinary tract infection (UTI), of varying severity is one of the most commonly encountered ailments in nephrology outpatient department (OPD). The commonest pathogens causing community acquired UTI (CAUTI) are E. Coli, Proteus mirabilis, Pseudomonas aeruginosa and Klebsiella pneumonia. There is a rapidly rising trend of antibiotic resistance among these uropathogens, may be due to indiscriminate antibiotic usage and poor patient compliance. We conducted a retrospective analysis of all culture proven UTI cases that attended the nephrology OPD of S. K. hospital, Trivandrum from August 2017 to July 2019 (24 months). 130 males and 121 females were included in the study. The mean age of the study group was 62.8 years with a male predominance in the age group above 50 years and a female predisposition in less than 50 years group. Commonest pathogen isolated in urine culture was E. coli (52.98%) followed by Klebsiella (39.09%), Citrobacter (8.76%), Pseudomonas (8.37%), Enterobacter (2.39%), Enterococci (1.99%), Candida (1.59%), Acinetobacter (1.2%), Proteus (1.2%), Streptococci (1.2%) and Serratia (0.4%).
Assessment of functional outcome of operative vs conservative management of displaced clavicle fractures
Authors: Singh Harpreet , Saoji Krushna , Tyagi Sangam , Patel Dhruv , Patel Parth , Patel Tilak
Published: April 2021

Background: clavicle fractures account for approximately 2.6% of all fractures. Middle third fractures account for 80% of all clavicle fractures. Historically, clavicle fractures have been treated mostly nonoperatively with clavicular brace, but due to increase rate of complications such as nonunion and malunion, clavicle fractures are now increasingly being treated surgically which results in lower rate of such complications, besides improved patient oriented outcome and early mobilization.

Methods: Current study is a prospective and observational comparative study, conducted over 30 patients diagnosed with displaced clavicle fractures coming to the department of orthopaedics in a tertiary care hospital in South Rajashthan between January 2019 to June 2020. Patients were then allotted alternatively into two groups. Patients selected for conservative treatment were treated with the figure of eight clavicle brace and arm sling pouch. Patients selected for operative treatment were treated with plating. Functional outcomes were assessed using Constant and Murley score in every follow up at 3 month and 6 month; and fracture union was assessed by serial radiographs taken at sixth week, third month and sixth month.

Results: Among 30 patients, 15 patients were treated conservatively and rest 15 patients were treated surgically with plating. Functional outcome at the end of third and sixth months of follow up were measured by using Constant Murley score and found significantly higher in operative group than conservative group.

Conclusions: In our study, it was found that at the end of 6 month follow up, patients treated surgically with plating had better functional outcomes than conservatively treated patients as measured by Constant and Murley score. It was also seen that, the duration of union and the incidence of complications was less in the operative group as compared to the conservative group.

 
Arthroscopic anterior cruciate ligament reconstruction using single bundle hamstring tendon autograft
Authors: Singh Harpreet , Patel Tilak , Agarwal Kamal Kumar , Patel Parth , Patel Dhruv , Saoji Krushna
Published: April 2021

Background: The present study was designed to analyze the postoperative outcome of arthroscopic anterior cruciate ligament (ACL) reconstruction with anatomical single bundle hamstring tendons autograft fixed in femoral tunnel using endobutton and in the tibial tunnel using interference screws and reinforced by anterior half of peroneus longus tendon (AHPLT), wherever required.

Methods: 39 patients of complete ACL tear underwent arthroscopic anatomical single bundle ACL reconstruction using quadrupled hamstring tendon autograft. It was ensured that the quadrupled graft had a length of at least 7 cm and thickness of at least 8 mm. If either of these requirements were not met, then the graft was supplemented by AHPLT. For functional assessment, international knee documentation committee (IKDC) knee score was taken and clinical tests for antero-posterior stability were done. In addition, the foot and ankle disability index (FADI) scores were used to evaluate the ankle donor site of the AHPLT.

Results: The average graft diameter was 8.74 mm and average graft length was 9.12 cm. There was significant improvement in post op IKDC score when compared with pre op score. There was no antero-posterior instability seen in any of the patients during follow up. 10 patients required an additional graft augmentation with AHPLT. There was no complaint about weakness of the ankle joint after surgery.

Conclusions: Arthroscopic ACL reconstruction with anatomical single bundle hamstring tendon autograft is an excellent treatment option for ACL deficient knees. It gives excellent functional outcome with minimal complications. Graft if small in diameter can be reinforced by AHPLT without any detrimental effect on ankle function.
A five year learning experience with sequence of events in a child with closed femur shaft fracture
Authors: Kulkarni Shrihari L. , Mannual Sunil , Daragad Manjunath , Patil Naveenkumar , Sharan Prateek M.
Published: April 2021

Femur shaft fractures are the most common fractures requiring hospitalization in children. Management of these fractures mainly depend on the age of the child. Associated injuries, fracture pattern, weight of the child and overlying soft tissue condition also influence the management. Still, the definitive treatment remains controversial in children between 5-16 years. We present our experience in management of 5 year old boy with mid shaft femur fracture and its complications. In his paper we want to highlight the importance of sticking to the basic principles and the recommendations in the management of the paediatric femur shaft fractures.