bluuebunny/crossref_metadata_2025 huggingface dataset:
Is There a Relationship between Shared Decision Making and Breast Cancer Patients’ Trust in Their Medical Oncologists?
Authors: Engelhardt Ellen G. , Smets Ellen M. A. , Sorial Irini , Stiggelbout Anne M. , Pieterse Arwen H. , Hillen Marij A.
Published: December 2019

Background. Adjuvant systemic treatment for early stage breast cancer significantly reduces the risk of mortality but is associated with side effects, reducing patients’ quality of life. Decisions about adjuvant treatment are preference sensitive and are thus ideally suited to a shared decision making (SDM) approach. Whether and how SDM affects patients’ trust in their oncologist is currently unknown. We investigated the association between patients’ trust in their oncologist and 1) observed level of SDM in the consultation, 2) congruence between patients’ preferred and perceived level of participation, and 3) patient and oncologist characteristics. Methods. Decision consultations ( n = 101) between breast cancer patients and their medical oncologist were audio-recorded and transcribed verbatim. Patients’ trust in their oncologist was measured using the Trust in Oncologist Scale (TiOS). The observed level of SDM was scored using the 12-item Observing Patient Involvement In Decision Making scale (OPTION-12), preferred level of participation with the Control Preferences Scale, and perceived level of participation with an open question in telephonic interviews. Results. The average TiOS score was high overall (mean [SD] = 4.1 [.56]; range, 2.6–5.0). Low levels of SDM were observed (mean [SD] = 16 [11.6]; range, 2–56). Neither observed nor perceived level of participation in SDM was associated with trust. Patients’ preferred and perceived role in decision making was incongruent in almost 50% of treatment decisions. Congruence was not related to trust. A larger tumor size (β = 4.5, P = 0.03) and the use of a risk prediction model during the consultation (β = 4.1, P = 0.04) were associated with stronger trust. Conclusion. Patients reported strong trust in their oncologist. While low levels of SDM were observed, SDM was not associated with trust. These findings suggest it may not be necessary to worry about negative consequences for trust of using SDM or risk prediction models in oncological consultations. Considering the increased emphasis on implementing SDM, it is important to further explore how SDM affects trust in clinical practice.
Isaac rebounds: A video game retelling of the Aqedah
Authors: Welton Rebekah
Published: December 2019

This article engages with a video game retelling of the biblical Aqedah and particularly focuses on the interactive nature of video games. In the game The Binding of Isaac, Isaac runs away from his parent, ‘Mom’, and fights back, which contrasts significantly with the passive and silent Isaac of the biblical text. The interactivity and immersion created by a video game medium has a significant impact on a player’s interpretation of the biblical story. This article argues that the video game depicts the Aqedah as horrific as a means to critique corporal punishment as used in some conservative Christian child-rearing strategies. Unfortunately, the game’s misogynistic portrayal of Isaac’s mother is deeply problematic, which this article also addresses.
Do Community Structural Characteristics Moderate the Association Between Mental Health and the Frequency and Severity of Violent-Behavioral Outcomes in Community Respondents?
Authors: Shaffer Catherine S. , Douglas Kevin S. , Fuller Erin K. , Blanchard Adam J. E. , Viljoen Jodi L.
Published: December 2019

In this prospective study, we examined the association between three types of mental health symptom clusters (i.e., psychotic, internalizing, and externalizing) and the frequency and severity of violent-behavioral outcomes, and whether community disadvantage, residential instability, and criminogenic facility density moderated these associations. Study data were derived from 258 community-dwelling adults nested in 60 postal forward sortation areas (FSAs) in a large metropolitan area in Western Canada who were assessed twice over a 6-month period. In addition, census and administrative data were obtained on the same areas. Controlling for sociodemographic characteristics (i.e., age, gender, ethnicity, relationship status, and employment status), lifetime history of violent-behavioral outcomes, and community structural characteristics, internalizing and externalizing mental health symptoms were significantly positively associated with the frequency and severity of subsequent violence perpetration and with the severity of subsequent violent victimization. Several significant interactions were observed: internalizing symptoms increased the risk of frequent and severe violence perpetration in FSAs with high but not low disadvantage, and externalizing symptoms increased the risk of frequent violent victimization in FSAs with a high but not low criminogenic facility density. Only the interactive association of internalizing symptoms and community disadvantage with the severity of violence perpetration, however, remained significant after Bonferroni correction was applied. These findings provide tentative support that associations between mental health and violent-behavioral outcomes can vary with community context. The implication of these findings for assessing and managing violent-behavioral outcomes in the community is discussed.
Reactions of Novice Interviewers Conducting Trauma Research With Marginalized Communities: A Qualitative Analysis
Authors: Smith Amber M. , Hamilton Alison B. , Loeb Tamra , Pemberton Jennifer , Wyatt Gail E.
Published: December 2019

Trauma-focused research highlights the reactions of seasoned professionals when engaging with vulnerable clients; however, less is known about the common reactions of novices engaged in trauma research, who may lack the skills to cope and interact with traumatized participants. The purpose of this study is to (a) describe common reactions experienced by novice trauma interviewers; (b) examine whether the issues they face are similar to those of seasoned helping professionals; and (c) discuss ways in which training and supervision can increase the well-being of interviewers in trauma research. A semi-structured assessment was administered to novice interviewers who had previously conducted psychosocial and trauma assessments with diverse community participants. Participation was voluntary. The assessment elicited responses concerning secondary traumatic stress, vicarious trauma, posttraumatic growth, and self-help and resources. Audio files were transcribed; responses were compiled to explore themes and identify illustrative quotes. Eight interviewers (two males, six females) participated. Six reported no prior experience working with populations with histories of trauma. Novice interviewers described experiences of secondary traumatic stress, vicarious trauma, compassion fatigue, posttraumatic growth, and resilience. Novice interviewers described symptoms consistent with those reported by seasoned helping professionals; positive and negative symptoms often coexisted. Interviewers who completed more assessments described reactions of sadness, anger, insomnia, and changes in worldview. Interviewers who shared similar traumatic histories or environments reported more examples of countertransference. All reported similar feelings of posttraumatic growth, such as hope and optimism, for their participants and an increased appreciation of their resilience. Implications for training and supervision are discussed.
Who Are the Stalking Victims? Exploring the Victimization Experiences and Psychosocial Characteristics of Young Male and Female Adults in Hong Kong
Authors: Chan Heng Choon (Oliver) , Sheridan Lorraine
Published: December 2019

Most stalking studies are conducted in the West. Limited information is available on victims of stalking from the Asian continent. This study specifically explored the victimization experiences of young male and female adults in Hong Kong. Using a large sample of university students ( N = 2,496) aged between 18 and 40 years, the gender distribution of stalking incident characteristics was examined, along with prevalence of various stalking behaviors, and victim–offender relationships by types of stalking behaviors. The differential role of demographic and psychosocial characteristics in stalking victimization experience was also explored. The lifetime prevalence rate of stalking victimization was 8.2%, with a higher estimate in females than males (11.6% vs. 3.8%). The sample analyzed in this study was 196 stalking victims. Although surveillance-oriented behaviors were most frequently reported by both males and females, significant gender differences in types of stalking behaviors were noted. Multivariate analyses indicated that increases in age and levels of self-esteem were correlated with an increased probability of experiencing stalking victimization, while being a male and higher levels of life satisfaction were related to a lower likelihood of falling prey to stalking victimization. This study concludes with a call for anti-stalking legislation in Hong Kong given the devastating nature and consequences of stalking victimization.
Toward Affirming Care: An Initial Evaluation of a Sexual Violence Treatment Network’s Capacity for Addressing the Needs of Trans Sexual Assault Survivors
Authors: Du Mont Janice , Kosa Sarah D. , Abavi Rebecca , Kia Hannah , Macdonald Sheila
Published: December 2019

There is a global call to action to improve transgender (trans) health to achieve health equity for people of all gender identities. Trans persons experience high rates of sexual assault and have historically had limited or no access to health care that meets their needs. As an initial step in addressing this, we evaluated a sexual assault treatment network’s capacity for addressing the needs of trans sexual assault survivors. Working with an Advisory Group comprising trans community members and their allies who have expertise in trans health, a short online questionnaire was developed and distributed to the program leaders of Ontario’s 35 hospital-based Sexual Assault/Domestic Violence Centres (SA/DVTCs). A total of 27 program leaders completed the questionnaire for a response rate of 77%. The majority of respondents reported that their program collaborates with trans-positive services within their community (70.4%). However, only two in five (40.7%) program leaders indicated that the patient bill of rights at their hospital included a statement pledging nondiscrimination on the basis of gender, gender identity, and/or gender expression. All (100%) program leaders felt that the nurses and physicians working within their programs would benefit from (further) training in the care of trans persons who have been sexually assaulted. This study represents an important step in a research program aimed at enhancing Ontario SA/DVTCs’ response to trans persons.
Vickers hardness indentation size effect in selective laser melted MS1 maraging steel
Authors: Balos Sebastian , Rajnovic Dragan , Sidjanin Leposava , Eric Cekic Olivera , Moraca Slobodan , Trivkovic Mirjana , Dedic Milan
Published: December 2019

In this paper, selective laser melting fabricated specimens in non-heat-treated and heat-treated conditions were subjected to Vickers microhardness testing, by using a full range of loadings: 10, 25, 50, 100, 200, 300, 500, and 1000 g. Microhardness of longitudinal sections and cross-sections were correlated and the obtained values were plotted against loadings and indentation size effect was studied, in order to find the optimal loading range, that gives the material true microhardness, or load-independent hardness. The load dependence of the measured Vickers hardness values was described quantitatively through the application of the Meyer’s law, proportional specimen resistance, and the modified proportional specimen resistance model. It was found that the microhardness rises as the loading is higher, causing a reversed indentation size effect, clearly indicating the range of true hardnesses of the tested material. Also, proportional specimen resistance and modified proportional specimen resistance models were found to have the highest correlation factors indicating their higher adequacy compared to Meyer’s prediction model.
Knowledge recommender system for complex product development using ontology and vector space model
Authors: Wu Zhenyong , Liu Haotian , Goh Mark
Published: December 2019

Knowledge recommendation has become a trend to improve the efficiency of acquiring knowledge during product development. As such, coping with the challenge of constantly discovering new knowledge is critical for knowledge reuse. This article proposes a knowledge recommendation framework based on design tasks, to facilitate the capturing and sharing of knowledge in manufacturing firms. An ontology-based knowledge representation model is designed and developed to organize the knowledge resources and a vector space model-based knowledge recommendation model is built to hasten the knowledge reuse process. A case study demonstrates the effectiveness of the proposed method.
Cellulitis: Home or Inpatient Intravenous Therapy in a Veteran Population
Authors: Wahking Rebekah A. , Clark Bonnie , Cheatham-Wilson Tasha
Published: December 2019

There are few studies describing outpatient parenteral antimicrobial therapy (OPAT) for cellulitis treatment. The Hospital in Home (HIH) program is a multidisciplinary team at the Cincinnati VA Medical Center (CVAMC) that provides acute care in patients’ homes similar to inpatient hospital care for a variety of indications, including cellulitis. Efficacy of OPAT for cellulitis treatment in the HIH program has not been directly compared with inpatient treatment. The primary objective of this retrospective review is to compare the rates of efficacy of intravenous (IV) antibiotics for cellulitis treatment for patients followed by HIH and inpatient settings. Treatment failure was defined as a change in IV antibiotic medications prescribed. A retrospective chart review was completed at CVAMC for patients enrolled in HIH ( n = 111) and patients who received inpatient treatment at CVAMC ( n = 111) with IV antibiotics for a primary diagnosis of cellulitis from January 1, 2014, through June 30, 2018. Six patients in the HIH group experienced IV antibiotic treatment failure compared with 11 in the inpatient group. The HIH group showed non-inferiority in rates of treatment failure compared with the inpatient group ( p = .21). OPAT with the HIH program appears to be non-inferior to inpatient IV antibiotic treatment for cellulitis infections. Tolerance issues and rates of adverse events do not appear to be worse in patients treated with OPAT in the Veteran population.
The performance of spiral groove dry gas seal under choked flow condition considering the real gas effect
Authors: Xu Hengjie , Song Pengyun , Mao Wenyuan , Deng Qiangguo
Published: December 2019

By taking carbon dioxide and hydrogen as lubricating gas, respectively, this paper presents an analysis on the pressure characteristics and temperature distribution of spiral groove dry gas seal which influenced by real gas effect under choked flow condition. Numerical results show that the deviation between real gas and ideal gas, which expressed by the deviation degree between compressibility factor Z and 1, is the main reason for real gas effect affecting sealing performance. Compared with ideal gas model, real gas effect raises exit pressure, opening force, leakage rate, Mach number in dam region, and temperature for carbon dioxide ( Z < 1), while it decreases those characteristics for hydrogen ( Z > 1) under the same operating conditions. In addition, choked flow effect increases opening force and reduces leakage rate and temperature-drop between entrance and exit of sealing clearance. Meanwhile, it may cause an unstable behavior for the seal.
Bullying Trends in the United States: A Meta-Regression
Authors: Kennedy Reeve S.
Published: December 2019

The current study used meta-regression to establish trends in bullying from 1998 to 2017, to identify factors that help explain variation in bullying trends, and to determine differences in the trends by gender and grade. This study focused on trends of face-to-face (FTF) bullying victimization and perpetration, cyberbullying victimization, relational bullying victimization, verbal bullying victimization, and physical bullying victimization, as well as characteristics of the youth involved. It also explored methodological and survey differences to help determine which factors contribute to variation from study to study. A systematic search found 91 studies reporting trends of bullying, from 1998 to 2017, that met predefined inclusion and exclusion criteria. The findings illustrate no significant time trend when looking at FTF bullying victimization, yet an increasing time trend for cyberbullying victimization. Additional trends begin to emerge when stratifying the findings by grade and gender, with FTF bullying victimization among boys declining, while FTF bullying victimization among girls is increasing. Across both FTF bullying victimization and cyberbullying victimization, younger adolescents report significantly more bullying than older adolescents, and this is consistent over time. Verbal and physical bullying victimization as well as FTF bullying perpetration have significantly declined over time. This study also identified key variables that contribute to the variation from trend study to trend study. The implications of these findings inform both policy and practice and provide insight into the overall scope of bullying within the United States.
Wireless power transfer from unmanned aerial vehicle to low-power wide area network nodes: Performance and business prospects for LoRaWAN
Authors: Tiurlikova Aleksandra , Stepanov Nikita , Mikhaylov Konstantin
Published: December 2019

Supported by the remarkable progress across many technological domains, the Internet of Things (IoT) ecosystem demonstrates steady growth over the few past years. This growth enables a number of new exciting applications. Nonetheless, hardly one can say today that the utility of the IoT is used to its full potential. This fact is especially notable for the monitoring applications deployed in remote areas. To address the needs of these use cases, in the article we propose a solution based on the combination of three key technologies: the low-power wide area networks, the unmanned aerial vehicles, and the wireless power transfer. In the article, we first detail the novel concept of a wireless power transfer-enabled unmanned aerial vehicle employed to charge the LoRaWAN sensor nodes. Then, via extensive simulations and analysis of an illustrative LoRaWAN application, we investigate both technical and, notably, business performance indicators, and compare them against the ones for a baseline scenario with no unmanned aerial vehicle. Our results illustratively demonstrate that in the long-term perspective, the inclusion of a wireless power transfer-enabled drone may drastically reduce the system’s operating expenses. At the very same time, our results highlight the limits, bottlenecks, and trade-offs related to the proposed concept, thus providing the basis and calling for further investigation.
Enabling real-time road anomaly detection via mobile edge computing
Authors: Zheng Zengwei , Zhou Mingxuan , Chen Yuanyi , Huo Meimei , Chen Dan
Published: December 2019

To discover road anomalies, a large number of detection methods have been proposed. Most of them apply classification techniques by extracting time and frequency features from the acceleration data. Existing methods are time-consuming since these methods perform on the whole datasets. In addition, few of them pay attention to the similarity of the data itself when vehicle passes over the road anomalies. In this article, we propose QF-COTE, a real-time road anomaly detection system via mobile edge computing. Specifically, QF-COTE consists of two phases: (1) Quick filter. This phase is designed to roughly extract road anomaly segments by applying random forest filter and can be performed on the edge node. (2) Road anomaly detection. In this phase, we utilize collective of transformation-based ensembles to detect road anomalies and can be performed on the cloud node. We show that our method performs clearly beyond some existing methods in both detection performance and running time. To support this conclusion, experiments are conducted based on two real-world data sets and the results are statistically analyzed. We also conduct two experiments to explore the influence of velocity and sample rate. We expect to lay the first step to some new thoughts to the field of real-time road anomalies detection in subsequent work.
Are Men Being Left Behind (Or Catching Up)? Differences in HPV Awareness, Knowledge, and Attitudes Between Diverse College Men and Women
Authors: Preston Sharice M. , Darrow William W.
Published: December 2019

The aim of this cross-sectional survey was to assess awareness, knowledge, and attitudes in regard to human papillomavirus (HPV) and vaccination against HPV among college students. From 2015 to 2017, 386 diverse undergraduates were recruited from a south Florida university. A survey, part of which was researcher developed, of HPV awareness, knowledge, and attitudes was conducted. The majority (84%) of participants had heard of HPV, and 70% had favorable attitudes toward vaccination. Only 28% of men and 55% of women had received ≥1 dose vaccine ( p = .01), and 4% of all participants reported that they had received 3 doses. Those with ≥1 dose ( n = 123, 40.1%) were more knowledgeable about HPV ( p = .01). High knowledge scores were recorded for 30% of respondents and were strongly associated with HPV vaccine initiation among both men and women ( p < .001) and perceived knowledge among women only ( p < .001). Negative attitudes toward HPV vaccine acceptance were associated with low knowledge scores ( p = .01) and undervaccination ( p < .001). Vaccinated women ( n = 95) were over seven times more likely than were unvaccinated women ( n = 115) to report positive vaccine attitudes (relative risk = 7.1). HPV vaccination status was not associated with vaccine attitudes among men. HPV knowledge and vaccine uptake remain problematic among college students, and deficits in both are associated with negative HPV vaccine attitudes. Although the knowledge gap is narrowing, HPV vaccination efforts should target young men, as HPV-related cancer morbidity continues to rise in men.
Obesity and metabolic health status are determinants for the clinical expression of hypertrophic cardiomyopathy
Authors: Park Jun-Bean , Kim Da Hye , Lee Heesun , Hwang In-Chang , Yoon Yeonyee E , Park Hyo Eun , Choi Su-Yeon , Kim Yong-Jin , Cho Goo-Yeong , Han Kyungdo , Ommen Steve R , Kim Hyung-Kwan
Published: December 2019

Aims

We sought to investigate the association of obesity and metabolic health status with the incidence of clinical hypertrophic cardiomyopathy (HCM) diagnosis in the general population. Our goal was to identify modifiable risk factors to attenuate clinical expression of HCM, enabling management evolution from a mostly passive strategy of risk stratification to a proactive strategy of modifying disease expression.

Methods

Using nationwide population-based data from the Korean National Health Insurance Service, 28,679,891 people who were free of prevalent HCM and who underwent health examinations between 2009 and 2015 were followed until 31 December 2016. The primary outcome was clinical HCM that was defined as incident diagnosis of HCM during the follow-up, after a blanking period of 12 months.

Results

Over a median follow-up of 5.2 years, 0.027% (n = 7851) of the study participants were diagnosed as incident HCM. The incidence rate per 1000 person-years was 0.059. A significant association was found between body mass index (BMI) and the incidence of clinical HCM after multivariate adjustment, with a hazard ratio per 1 kg/m2 increase in BMI of 1.063 (95% confidence interval 1.051–1.075). Metabolically unhealthy participants had a greater incidence of HCM than metabolically healthy participants, regardless of obesity status. The effect of BMI was more pronounced in several subgroups, including participants with no hypertension, those aged less than 65 years and men.

Conclusion

We found that individuals with obesity and/or metabolic abnormalities had a significantly higher incidence of clinical HCM diagnosis than their counterparts. Efforts to manage obesity and metabolic abnormalities may be important in modifying clinical expression of HCM.
Experiences of women receiving mhealth-supported antenatal care in the village from community health workers in rural Burkina Faso, Africa
Authors: Arnaert Antonia , Ponzoni Norma , Debe Zoumanan , Meda Mouoboum M , Nana Noufou G , Arnaert Stijn
Published: December 2019

Objective

This qualitative study explored the experiences of women receiving mhealth-supported antenatal care in a village, from community health workers (CHWs) in rural Burkina Faso, Africa.

Intervention

CHWs entered patient clinical data manually in their smartphone during their home visits. All wireless transferred data was monitored by the midwives in the community clinic for arising medical complications.

Methods

Semi-structured interviews were conducted with 19 pregnant women, who were housewives, married and their age ranged from 18 to 39 years. None had completed their formal education. Depending on the weeks of gestation during their first antenatal care visit, length of enrollment in the project varied between three and eight months. Transcripts were content-analyzed.

Results

Despite the fact that mhealth was a novel service for all participants, they expressed appreciation for these interventions, which they found beneficial on three levels: 1) it allowed for early detection of pregnancy-related complications, 2) it was perceived as promoting collaboration between CHWs and midwives, and 3) it was a source of reassurance during a time when they are concerned about their health. Although not unanimous, certain participants said their husbands were more interested in their antenatal care as a result of these services.

Conclusion

Findings suggested that mhealth-supported visits of the CHWs have the potential to increase mothers’ knowledge about their pregnancy and, as such, motivate them to attend more ANC visits. In response to this increased patient engagement, midwives approached women differently, which led to the mothers’ perception of improvement in the patient–provider relationship. Results also indicated that mhealth may increase spousal involvement, as services are offered at home, which is an environment where spouses feel more comfortable.
Mobile learning device increased study efficiency for radiology residents but with risk of temporary novelty effect
Authors: Björkman Ann-Sofi , Spångeus Anna , Woisetschläger Mischa
Published: December 2019

Background

Digital resources in learning are increasingly available and offer new possibilities in education. Mobile learning devices (MLD) such as tablets provide easy and flexible access for users.

Purpose

To investigate whether the introduction of MLDs in radiology education affected time spent on studies over a longer time frame and whether learning behavior and attitudes changed.

Material and Methods

The radiology residents employed during 2015–2016 were invited to participate in this 12-month MLD intervention study. Results were evaluated using online questionnaires at six months (6 m) and 12 months (12 m).

Results

Thirty-one residents were included, of whom half were in the early stages of residency (<2 years). After the MLD introduction, most participants (91% [6 m] and 83% [12 m]) estimated increased time spent on studies. Of these, 32% stated “a lot more” at 6 m but only 8% at 12 m ( P = 0.12). The MLDs showed positive effects on the experience of radiology studies, as a majority of participants stated better quality and effectiveness in their studies (100% [6 m]–92% [12 m]), that MLD facilitated access to educational materials to a high degree (83% [6 m]–75% [12 m]), and that studies had become better and more fun (96% [6 m]–100% [12 m]).

Conclusion

The use of MLDs seems to facilitate learning effectively for radiologic residents. However, a larger scale study is required as a trend of decreasing figures in the longer term was seen, but our results did not show a significant reduction of time spent on radiology studies.
Evaluation of Surface Roughness of Composite, Compomer and Carbomer After Curing Through Mylar Strip and Glycerin: A Comparative Study
Authors: Topaloglu-Ak Asli , Çayırgan Dilara , Uslu Melisa
Published: December 2019

Aim:

To compare the effect of mylar strip and glycerin topical application on the surface roughness of composite, compomer, and carbomer during polymerization.

Materials and Method:

Each of 45 disc-shaped specimens of Z250, Dyract, Carbomer, were prepared according to manufacturer’s instructions and molded in silicone rubber molds by one operator (5 mm diameter × 2 mm thickness; n = 135). Each restorative group was divided into 3 groups as oxygen group (control), mylar strip, and glycerin group (n = 15). In the control group, specimens were light cured in the open air for 40 s, whereas in the test groups they were covered either with a mylar strip or a drop of glycerin solution and cured for 40 s. Glycerin was rinsed off before polishing. Sof-Lex discs were used for polishing before the surface roughness measurements by a profilometer. The obtained data were statistically analyzed using two-way analysis of variance at a confidence level of 95% ( P < .05).

Results:

The mean surface roughness values of composite, compomer, and carbomer polymerized in air, through mylar strip and glycerin showed no statistically significant difference ( P > .05).

Conclusion:

Mylar strip and glycerin application did not affect the surface roughness of the composite, compomer, and carbomer. Polishing may mask the effect of different curing conditions.
Chronic Eosinophilic Pneumonia in an Airbrush Painter With Poor Response to Systemic Steroids
Authors: Taha Ahmed , Ahmed Roaa , Merza Nooraldin , Bharadwaj Ravindra , Vo Thien , Patel Manish
Published: December 2019

Airbrush paints contain low-molecular-weight chemicals that can cause occupational asthma, respiratory sensitization, and hypersensitivity pneumonitis; however, its relationship to chronic eosinophilic pneumonia (CEP) has never been reported. In this article, we are presenting a unique association between CEP and prolonged exposure to acrylic airbrush paints. Unlike the vast majority of CEP patients who exhibit an excellent response to systemic steroids, our patient did not respond to systemic steroids. We believe that his prolonged exposure to airbrush paints and the evolution of organizing pneumonia might have contributed to the unsatisfactory response to systemic steroids, prolonged hypoxia, and the overall worse prognosis. There are no current data that correlate acrylic paints to the development of CEP; our report is the first to introduce a probe to further investigate this association.
Scapula Fractures in Elite Soccer and Rugby Players
Authors: McIntosh Jerome , Akhbari Pouya , Malhas Amar , Funk Lennard
Published: December 2019

Background:

Scapula fractures are uncommon in sports and are poorly understood in this patient group.

Purpose:

To report on scapula fractures in contact and collision athletes and assess the injury patterns of different mechanisms of injury.

Study Design:

Case series; Level of evidence, 4.

Methods:

A retrospective case series was performed of all sports-related scapula fractures treated at a single institution between 2007 and 2015. The mechanisms of injury were divided into direct lateral impact, fall onto an outstretched arm, or abduction/external rotation.

Results:

A total of 11 patients were identified: 9 professional rugby players, 1 professional soccer player, and 1 amateur soccer player. The mean age was 28 years (range, 18-35 years). The mean return to play was 127 days in those treated nonoperatively and 163 days in those treated operatively. A direct impact mechanism occurred in 7 patients, all of whom sustained glenoid neck and body fractures and were treated nonoperatively. Two rugby players had a concomitant suprascapular nerve injury. An outstretched arm mechanism occurred in 2 cases, leading to posterior and inferior glenoid fractures. Both patients were treated operatively. An abduction/external rotation mechanism occurred in 2 cases, resulting in an anteroinferior and an anterior glenoid rim fracture. One case was treated operatively and the other was treated nonoperatively. Of those with glenoid fractures, 75% were not visible on plain radiographs and required further imaging.

Conclusion:

Scapula fractures acquired in sports are a serious injury with a prolonged recovery period. The mechanism of injury can help predict the injury pattern and highlight the need for further imaging. There is a high association with suprascapular nerve injuries.
Childhood and Adolescent Obesity in the United States: A Public Health Concern
Authors: Sanyaolu Adekunle , Okorie Chuku , Qi Xiaohua , Locke Jennifer , Rehman Saif
Published: December 2019

Childhood and adolescent obesity have reached epidemic levels in the United States. Currently, about 17% of US children are presenting with obesity. Obesity can affect all aspects of the children including their psychological as well as cardiovascular health; also, their overall physical health is affected. The association between obesity and other conditions makes it a public health concern for children and adolescents. Due to the increase in the prevalence of obesity among children, a variety of research studies have been conducted to discover what associations and risk factors increase the probability that a child will present with obesity. While a complete picture of all the risk factors associated with obesity remains elusive, the combination of diet, exercise, physiological factors, and psychological factors is important in the control and prevention of childhood obesity; thus, all researchers agree that prevention is the key strategy for controlling the current problem. Primary prevention methods are aimed at educating the child and family, as well as encouraging appropriate diet and exercise from a young age through adulthood, while secondary prevention is targeted at lessening the effect of childhood obesity to prevent the child from continuing the unhealthy habits and obesity into adulthood. A combination of both primary and secondary prevention is necessary to achieve the best results. This review article highlights the health implications including physiological and psychological factors comorbidities, as well as the epidemiology, risk factors, prevention, and control of childhood and adolescent obesity in the United States.
Outcomes of Rhegmatogenous Retinal Detachment Repair With Nonrestricted Postoperative Positioning
Authors: Soliman Mohamed Kamel , Nithianandan Harrish , McDonald Heather , Lingley Alexander J. , Tuli Raman
Published: December 2019

Purpose:

To investigate the anatomical success rate associated with rhegmatogenous retinal detachment (RRD) repair without postoperative head positioning.

Methods:

Data on 182 individuals undergoing pars plana vitrectomy (PPV) with or without phacoemulsification or scleral buckle for primary RRD with intraocular tamponade were retrospectively reviewed. The primary outcome was the initial anatomical success rate. Secondary outcome measures were the change in best-corrected visual acuity and the final reattachment rate.

Results:

A total of 122 eyes from 122 patients who underwent RRD repair without postoperative positioning were included in this study. PPV alone was performed in 39% of cases, whereas the remaining patients had PPV combined with phacoemulsification (35%), with scleral buckle (19%), or both (7%). Inferior breaks between the 4 o’clock and 8 o’clock positions were present in 47% of cases. Primary and final anatomical success was achieved in 86% and 98% of cases, respectively. The most common cause for redetachment was proliferative vitreoretinopathy. Age and combined inferior retinal and superior breaks were predictive of recurrence in the logistic regression model. The mean baseline best-corrected visual acuity improved from 1.2 (Snellen equivalent, 20/320) to 0.76 (Snellen, 20/125) logarithm of the minimum angle of resolution after retinal reattachment ( P < .001).

Conclusions:

PPV combined with or without phacoemulsification or scleral buckle for primary RRD in pseudophakic eyes or those rendered pseudophakic is associated with good anatomical outcomes without restricted postoperative head positioning. Retinal detachment in eyes with combined retinal inferior and superior breaks may have a lower success rate, and whether this is due to lack of postoperative positioning needs further evaluation in prospective, controlled studies.
Expression profiles of long noncoding RNAs and messenger RNAs in the border zone of myocardial infarction in rats
Authors: Meng Qingkun , Sun Zhijun , Gu Hui , Luo Jiaying , Wang Jingjing , Wang Chuanhe , Han Su
Published: December 2019

Background

The participation of long noncoding RNAs (lncRNAs) in myocardial infarction has recently been noted. However, their underlying roles in the border zone of myocardial infarction remain unclear. This study uses microarrays to determine the profiles of lncRNAs and mRNAs in the border zone.

Methods

Bioinformatics methods were employed to uncover their underlying roles. Highly dysregulated lncRNAs was further validated via PCR.

Results

Four hundred seven lncRNAs and 752 mRNAs were upregulated, while 132 lncRNAs and 547 mRNAs were downregulated in the border zone of myocardial infarction. A circos graph was constructed to visualize the chromosomal distribution and classification of the dysregulated lncRNAs and mRNAs. The upregulated mRNAs in the border zone were most highly enriched in cytokine activity, binding, cytokine receptor binding and related processes, as ascertained through Go analysis. Pathway analysis of the upregulated mRNAs showed the most significant changes were in the TNF signaling pathway, cytokine–cytokine receptor interaction and chemokine signaling pathway and similar pathways and interactions. An lncRNA–mRNA co-expression network was established to probe into the underlying functions of the 10 most highly dysregulated lncRNAs based on their co-expressed mRNAs. In the co-expression network, we found 16 genes directly involved in myocardial infarction, including Alox5ap, Itgb2 and B4galt1. The lncRNAs AY212271, EF424788 and MRAK088538, among others, might be associated with myocardial infarction. BC166504 is probably a key lncRNA in the border zone of myocardial infarction.

Conclusions

The results may have revealed some aberrantly expressed lncRNAs and mRNAs that contribute to the underlying pathophysiological mechanisms of myocardial infarction.
Prevalence and associated factors of scabies among schoolchildren in Dabat district, northwest Ethiopia, 2018
Authors: Dagne Henok , Dessie Awrajaw , Destaw Bikes , Yallew Walelegn Worku , Gizaw Zemichael
Published: December 2019

Background

Scabies is a skin infestation caused by the mite Sarcoptes scabiei that causes a pruritic skin eruption. In Ethiopia, the disease is common especially during natural or manmade disasters such as flooding, drought, civil war and conflict, poor water supply and sanitation, and overcrowding living condition. Though scabies is becoming a major public health problem, especially in low resource settings, there has been no study that reported the prevalence of scabies in the study area. The aim of this study, therefore, was to assess the prevalence of scabies and associated factors among students in primary schools in Dabat district, northwest Ethiopia.

Method

An institutional-based cross-sectional study was employed to determine the prevalence of scabies and associated factors among schoolchildren in Dabat district. A total of 494 students selected by a multi-stage sampling technique were included in this study. Scabies was diagnosed by medical practitioners based on lesions observed on body surfaces after a physical examination. Bivariable and multivariable binary logistic regression analyses were performed using SPSS version 20. Significance level was obtained at p value < 0.05.

Result

The prevalence of scabies was 9.3% (46/494) with 95% CI (5.66%, 12.94%). Among schoolchildren who were infested by scabies, 65.22% (30/46) had a mild, 28.26% (13/46) had moderate, and 6.52% (3/46) had severe lesions. Studying at a rural school (AOR = 2.99, 95% CI 1.33, 6.71), had illiterate father (AOR = 5.11, 95% CI 2.25, 11.58), being grade level 1–4 (AOR = 3.91, 95% CI 1.69, 9.05), rarely taking a bath (AOR = 3.54, 95% CI 1.36, 9.25), contact with a person with itching symptom (AOR = 2.66, 95% CI 1. 21, 5.83), a family member with itchy symptoms (AOR = 4.76, 95% CI 2.20, 10.28), not living with both parents (AOR = 2.49, 95% CI 1.02, 6.06), and using water only for hand washing (AOR = 4.38, 95% CI 1.78, 10.76) were factors associated with scabies infestation among schoolchildren.

Conclusion

The prevalence of human scabies among schoolchildren in Dabat district northwest Ethiopia was high. The school localization, first cycle level of education, paternal educational status, frequency of taking a bath, and contact with a person having itchy lesions, presence of a family member with itchy lesion, and type of frequently used hand washing material were the factors significantly impacting the occurrence of scabies. Special attention should be given to students at first cycle education as they are at the highest risk of infestation.
Human-specific mutations in VMAT1 confer functional changes and multi-directional evolution in the regulation of monoamine circuits
Authors: Sato Daiki X. , Ishii Yuu , Nagai Tomoaki , Ohashi Kazumasa , Kawata Masakado
Published: December 2019

Background

Neurochemicals like serotonin and dopamine play crucial roles in human cognitive and emotional functions. Vesicular monoamine transporter 1 (VMAT1) transports monoamine neurotransmitters, and its variant (136Thr) is associated with various psychopathological symptoms and reduced monoamine uptake relative to 136Ile. We previously showed that two human-specific amino acid substitutions (Glu130Gly and Asn136Thr/Ile) of VMAT1 were subject to positive natural selection. However, the potential functional alterations caused by these substitutions (Glu130Gly and Asn136Thr) remain unclear. To assess functional changes in VMAT1 from an evolutionary perspective, we reconstructed ancestral residues and examined the role of these substitutions in monoamine uptake in vitro using fluorescent false neurotransmitters (FFN), which are newly developed substances used to quantitatively assay VMATs.

Results

Immunoblotting confirmed that all the transfected YFP-VMAT1 variants are properly expressed in HEK293T cells at comparable levels, and no significant difference was seen in the density and the size of vesicles among them. Our fluorescent assays revealed a significant difference in FFN206 uptake among VMAT1 variants: 130Glu/136Asn, 130Glu/136Thr, and 130Gly/136Ile showed significantly higher levels of FFN206 uptake than 130Gly/136Asn and 130Gly/136Thr, indicating that both 130Glu and 136Ile led to increased neurotransmitter uptake, for which 136Thr and 136Asn were comparable by contrast.

Conclusions

These findings suggest that monoamine uptake by VMAT1 initially declined (from 130Glu/136Asn to 130Gly/136Thr) in human evolution, possibly resulting in higher susceptibility to the external environment of our ancestors.
Comparative gene expression profiling of muscle reveals potential candidate genes affecting drip loss in pork
Authors: Zhao Xueyan , Wang Cheng , Wang Yanping , Lin Haichao , Wang Huaizhong , Hu Hongmei , Wang Jiying
Published: December 2019

Background

Drip loss is a key aspect of meat quality. Transcriptome profiles of muscle with divergent drip loss would offer important insight into the genetic factors responsible for the trait. In this study, drip loss and other meat quality traits of 28 purebred Duroc pigs were measured, muscles of these individuals were RNA sequenced, and eight individuals with extremely low and high drip loss were selected for analyzing their transcriptome differences and identifying potential candidate genes affecting drip loss.

Results

As a result, 363 differentially expressed (DE) genes were detected in the comparative gene expression analysis, of which 239 were up-regulated and 124 were down-regulated in the low drip loss group. The DE genes were further filtered by correlation analysis between their expression and drip loss values in the 28 Duroc pigs measured and comparison of them with QTLs affecting drip loss. Consequently, of the 363 DE genes, 100 were identified as critical DE genes for drip loss. Functional analysis of these critical DE genes revealed some GO terms (extracellular matrix, cell adhesion mediated by integrin, heterotypic cell-cell adhesion), pathway (ECM-receptor interaction), and new potential candidate genes (TNC, ITGA5, ITGA11, THBS3 and CD44) which played an important role in regulating the variation of drip loss, and deserved to carry further studies to unravel their specific mechanism on drip loss.

Conclusions

Our study revealed some GO terms, pathways and potential candidate genes affecting drip loss. It provides crucial information to understand the molecular mechanism of drip loss, and would be of help for improving meat quality of pigs.
Effect of tetracycline treatment regimens on antibiotic resistance gene selection over time in nursery pigs
Authors: Græsbøll Kaare , Larsen Inge , Clasen Julie , Birkegård Anna Camilla , Nielsen Jens Peter , Christiansen Lasse Engbo , Olsen John Elmerdahl , Angen Øystein , Folkesson Anders
Published: December 2019

Background

The majority of antimicrobials given during the production of pigs are given to nursery pigs. The influence of antimicrobial use on the levels of antimicrobial resistant (AMR) genes is important to quantify to be able to assess the impact of resistance on the food chain and risk to human and animal health.

Results

This study investigated the response on the levels of nine AMR genes to five different treatment strategies with oxytetracycline, and the dynamics of gene abundance over time by following 1167 pigs from five different farms in Denmark.

The results showed no significant difference between treatments and an increase in abundance for the efflux pump encoding tet(A) gene and the genes encoding the ribosomal protection proteins tet(O) and tet(W) tetracycline resistant genes following treatment, while tet(M) showed no response to treatment. However, it was also observed that the levels of tet(O), tet(W), and ermB in some farms would drift more over time compared to a single treatment-course with antibiotic.

Conclusion

This study underlines the large variation in AMR levels under natural conditions and the need for increased investigation of the complex interactions of antimicrobial treatment and other environmental and managerial practices in swine production on AMR gene abundance.