bluuebunny/crossref_metadata_2025 huggingface dataset:
The Relationship between Rainfall Pattern and Epilithic Diatoms in Four Streams of Central-Western Korea for Three Years (2013–2015)
Authors: Hwang Eun-A , Cho In-Hwan , Kim Ha-Kyung , Yi Chen , Kim Baik-Ho
Published: February 2023

To study the effect of rainfall patterns on diatom communities in four major central western streams on the Korean Peninsula during the monsoon seasons of 2013 through 2015, we measured precipitation, environmental factors, and epilithic diatoms at 42 sites before (May) and after (August and September) each monsoon. The Mangyeonggang river and Sapgyocheon stream (SS) had a high percentage of low-permeability soil, and the stream had the highest proportion (49.1%) of surrounding land in urban areas. Precipitation and precipitation frequency was closely correlated with electrical conductivity and nutrients, and this was particularly evident in SS. Epilithic diatom abundance for the most abundant species as, Navicula minima, decreased in the stream in 2013 and 2014 and increased in 2015 when precipitation and precipitation frequency were low. This was not clearly distinguishable in the ecological characteristics of each watercourse’s indicator species, except in SS. The dynamic community index was highest in 2015 (ca. 5.50), and the annual changes in the index were clearly shown in SS. The precipitation pattern and the dynamic community index were negatively correlated (r = −0.026~−0.385), and the precipitation within 2 weeks (r = −0.480 for SS) before the second sampling and the frequency of 10 mm of precipitation were closely correlated in the stream (r = −0.450 for SS). The distribution of epilithic diatoms in the four watercourses is therefore affected by monsoon precipitation and precipitation frequency, and the dynamic community index is determined by soil characteristics and land use.
A Model for Predicting and Grading the Quality of Grain Storage Processes Affected by Microorganisms under Different Environments
Authors: Zhang Qingchuan , Li Zihan , Dong Wei , Wei Siwei , Liu Yingjie , Zuo Min
Published: February 2023

Changes in storage environments have a significant impact on grain quality. Accurate prediction of any quality changes during grain storage in different environments is very important for human health. In this paper, we selected wheat and corn, which are among the three major staple grains, as the target grains whose storage monitoring data cover more than 20 regions, and constructed a grain storage process quality change prediction model, which includes a FEDformer-based grain storage process quality change prediction model and a K-means++-based grain storage process quality change grading evaluation model. We select six factors affecting grain quality as input to achieve effective prediction of grain quality. Then, evaluation indexes were defined in this study, and a grading evaluation model of grain storage process quality was constructed using clustering model with the index prediction results and current values. The experimental results showed that the grain storage process quality change prediction model had the highest prediction accuracy and the lowest prediction error compared with other models.
Exploratory Factor Analysis (EFA) of the Short Functional Geriatric Evaluation (SFGE) to Assess the Multidimensionality of Frailty in Community-Dwelling Older Adults
Authors: Liotta Giuseppe , Lorusso Grazia , Madaro Olga , Formosa Valeria , Gialloreti Leonardo , Donnoli Clara , Riccardi Fabio , Orlando Stefano , Scarcella Paola , Apostolo Joao , Silva Rosa , Dantas Carina , van Staalduinen Willeke , De Luca Vincenzo , Illario Maddalena , Gentili Susanna , Palombi Leonardo
Published: February 2023

The Short Functional Geriatric Evaluation (SFGE) is a multidimensional and short questionnaire to assess biopsychosocial frailty in older adults. This paper aims to clarify the latent factors of SFGE. Data were collected from January 2016 to December 2020 from 8800 community-dwelling older adults participating in the “Long Live the Elderly!” program. Social operators administered the questionnaire through phone calls. Exploratory factor analysis (EFA) was carried out to identify the quality of the structure of the SFGE. Principal component analysis was also performed. According to the SFGE score, 37.7% of our sample comprised robust, 24.0% prefrail, 29.3% frail, and 9.0% very frail individuals. Using the EFA, we identified three main factors: psychophysical frailty, the need for social and economic support, and the lack of social relationships. The Kaiser–Meyer–Olkin measure of sampling adequacy was 0.792, and Bartlett’s test of sphericity had a statistically significant result (p-value < 0.001). The three constructs that emerged explain the multidimensionality of biopsychosocial frailty. The SFGE score, 40% of which is social questions, underlines the crucial relevance of the social domain in determining the risk of adverse health outcomes in community-dwelling older adults.
Finite Elements Analysis of Tooth—A Comparative Analysis of Multiple Failure Criteria
Authors: Moga Radu Andrei , Olteanu Cristian Doru , Daniel Botez Mircea , Buru Stefan Marius
Published: February 2023

Herein Finite elements analysis (FEA) study assesses the adequacy and accuracy of five failure criteria (Von Mises (VM), Tresca, maximum principal (S1), minimum principal (S3), and Hydrostatic pressure) for the study of tooth as a structure (made of enamel, dentin, and cement), along with its stress absorption–dissipation ability. Eighty-one 3D models of the second lower premolar (with intact and 1–8 mm reduced periodontium) were subjected to five orthodontic forces (intrusion, extrusion, tipping, rotation, and translation) of 0.5 N (approx. 50 gf) (in a total of 405 FEA simulations). Only the Tresca and VM criteria showed biomechanically correct stress display during the 0–8 mm periodontal breakdown simulation, while the other three showed various unusual biomechanical stress display. All five failure criteria displayed comparable quantitative stress results (with Tresca and VM producing the highest of all), showing the rotational and translational movements to produce the highest amount of stress, while intrusion and extrusion, the lowest. The tooth structure absorbed and dissipated most of the stress produced by the orthodontic loads (from a total of 0.5 N/50 gf only 0.125 N/12.5 gf reached PDL and 0.01 N/1 gf the pulp and NVB). The Tresca criterion seems to be more accurate than Von Mises for the study of tooth as structure.
A Novel Approach for Spatially Controllable High-Frequency Forecasts of Park Visitation Integrating Attention-Based Deep Learning Methods and Location-Based Services
Authors: Lu Ming , Xie Qian
Published: February 2023

Forecasting tourism volume can provide helpful information support for decision-making in managing tourist attractions. However, existing studies have focused on the long-term and large-scale prediction and scarcely considered high-frequency and micro-scale ones. In addition, the current approaches are limited regarding forecasting the visitor volume of a designated sub-area in a tourist attraction. This sub-area forecast can assist local-scaled managing decisions of tourist attractions, particularly for large-scale tourist attractions. Therefore, to achieve high-frequency forecasts of tourist volume for finer scale areas such as parks and their sub-areas and generate more controllable and flexible forecasts, this study developed a novel method that incorporates a forecasting model composed of multiple deep learning components and a designed control mechanism. The control mechanism produces high-temporal-resolution sequences of tourist volume for designated sub-areas, and the forecasting model is built on an attention-based deep-bidirectional neural network to better capture the long-range dependencies of the sequence and enhance the forecasting accuracy and robustness. The experimental research was performed at Taiyangdao Park and its two designated sub-areas to validate the effectiveness and superiority of the proposed method compared to other widely used deep-learning methods; three types of performance evaluations were adopted including fitting methods, error measures, and Diebold–Mariano tests. The results demonstrated that the proposed method provided outstanding performance in high-frequency forecasts and yielded more desired forecasting outcomes than other widely used forecasting methods. Furthermore, the comparison with the performances of various other deep learning models provide insights concerning their forecasting capacity; for instance, bidirectional RNN models tend to achieve better forecasts than general RNN models in the high-frequency forecasts. The proposed method has significant practical applicability in aiding short-term micro-scale management decisions and can also serve as an alternative approach in the field of tourist volume forecasting.
Putative Role of Neutrophil Extracellular Trap Formation in Chronic Myeloproliferative Neoplasms
Authors: Marković Dragana C. , Maslovarić Irina S. , Kovačić Marijana , Vignjević Petrinović Sanja , Ilić Vesna Lj.
Published: February 2023

Myeloproliferative neoplasms (MPNs) are hematologic malignancies characterized by gene mutations that promote myeloproliferation and resistance to apoptosis via constitutively active signaling pathways, with Janus kinase 2-signal transducers and the activators of transcription (JAK-STAT) axis as a core part. Chronic inflammation has been described as a pivot for the development and advancement of MPNs from early stage cancer to pronounced bone marrow fibrosis, but there are still unresolved questions regarding this issue. The MPN neutrophils are characterized by upregulation of JAK target genes, they are in a state of activation and with deregulated apoptotic machinery. Deregulated neutrophil apoptotic cell death supports inflammation and steers them towards secondary necrosis or neutrophil extracellular trap (NET) formation, a trigger of inflammation both ways. NETs in proinflammatory bone marrow microenvironment induce hematopoietic precursor proliferation, which has an impact on hematopoietic disorders. In MPNs, neutrophils are primed for NET formation, and even though it seems obvious for NETs to intervene in the disease progression by supporting inflammation, no reliable data are available. We discuss in this review the potential pathophysiological relevance of NET formation in MPNs, with the intention of contributing to a better understanding of how neutrophils and neutrophil clonality can orchestrate the evolution of a pathological microenvironment in MPNs.
Mechanisms of Long Non-Coding RNA in Breast Cancer
Authors: Giuliani Bianca , Tordonato Chiara , Nicassio Francesco
Published: February 2023

The landscape of pervasive transcription in eukaryotic genomes has made space for the identification of thousands of transcripts that are difficult to frame in a specific functional category. A new class has been broadly named as long non-coding RNAs (lncRNAs) and shortly defined as transcripts that are longer than 200 nucleotides with no or limited coding potential. So far, about 19,000 lncRNAs genes have been annotated in the human genome (Gencode 41), nearly matching the number of protein-coding genes. A key scientific priority is the functional characterization of lncRNAs, a major challenge in molecular biology that has encouraged many high-throughput efforts. LncRNA studies have been stimulated by the enormous clinical potential that these molecules promise and have been based on the characterization of their expression and functional mechanisms. In this review, we illustrate some of these mechanisms as they have been pictured in the context of breast cancer.
Soluble Epoxide Hydrolase Contributes to Cell Senescence and ER Stress in Aging Mice Colon
Authors: Wang Weicang , Wagner Karen M. , Wang Yuxin , Singh Nalin , Yang Jun , He Qiyi , Morisseau Christophe , Hammock Bruce D.
Published: February 2023

Aging, which is characterized by enhanced cell senescence and functional decline of tissues, is a major risk factor for many chronic diseases. Accumulating evidence shows that age-related dysfunction in the colon leads to disorders in multiple organs and systemic inflammation. However, the detailed pathological mechanisms and endogenous regulators underlying colon aging are still largely unknown. Here, we report that the expression and activity of the soluble epoxide hydrolase (sEH) enzyme are increased in the colon of aged mice. Importantly, genetic knockout of sEH attenuated the age-related upregulation of senescent markers p21, p16, Tp53, and β-galactosidase in the colon. Moreover, sEH deficiency alleviated aging-associated endoplasmic reticulum (ER) stress in the colon by reducing both the upstream regulators Perk and Ire1 as well as the downstream pro-apoptotic effectors Chop and Gadd34. Furthermore, treatment with sEH-derived linoleic acid metabolites, dihydroxy-octadecenoic acids (DiHOMEs), decreased cell viability and increased ER stress in human colon CCD-18Co cells in vitro. Together, these results support that the sEH is a key regulator of the aging colon, which highlights its potential application as a therapeutic target for reducing or treating age-related diseases in the colon.
Management of Panonychus ulmi with Various Miticides and Insecticides and Their Toxicity to Predatory Mites Conserved for Biological Mite Control in Eastern U.S. Apple Orchards
Authors: Joshi Neelendra K. , Phan Ngoc T. , Biddinger David J.
Published: February 2023

Panonychus ulmi (Koch) (Acari: Tetranychidae), commonly known as European red mite, is a polyphagous pest of various tree and small fruit crops, including apples. A field study was conducted to evaluate different pesticide options available for the management of P. ulmi, and their impact on the population of non-target predatory mite species complex consisting of Neoseiulus fallacis, Typhlodromus pyri, and Zetzellia mali in apple orchards. Pesticides were applied using a commercial airblast sprayer at the 3–5 mite/leaf recommended economic Integrated Pest Management (IPM) threshold or prophylactically in the spring ignoring IPM practices such as monitoring, reliance on biological control and economic thresholds. Effects on the motile and egg stages of P. ulmi were evaluated as were effects on the populations of predatory mites through frequent leaf counts during the season. We also recorded the subsequent overwintering eggs of P. ulmi from each pesticide treatment. The two prophylactic treatments containing a mixture of zeta-cypermethrin + avermectin B1 + 1% horticultural oil and abamectin + 1% horticultural oil provided effective control of P. ulmi population throughout the season without reducing predatory mite populations. In contrast, eight treatments applied at the recommended economic threshold of 3–5 mites/leaf were not effective in suppressing P. ulmi populations and most reduced predatory mites. Etoxazole had significantly higher number of overwintering P. ulmi eggs compared to all other treatments.
Effects of Prenatal Paracetamol Exposure on the Development of Asthma and Wheezing in Childhood: A Systematic Review and Meta-Analysis
Authors: Barańska Agnieszka , Kanadys Wiesław , Wdowiak Artur , Malm Maria , Błaszczuk Agata , Religioni Urszula , Wdowiak-Filip Anita , Polz-Dacewicz Małgorzata
Published: February 2023

The aim of the report was to evaluate whether in utero exposure to paracetamol is associated with risk towards developing respiratory disorders such as asthma and wheeze after birth. MEDLINE (PubMed), EMBASE and Cochrane Library databases were searched for articles published in English to December 2021. The study involved 330,550 women. We then calculated the summary risk estimates and 95% CIs and plotted forest plots using random effect models (DerSimonian–Laird method) and fixed effect models. We also performed a systematic review of the chosen articles and a meta-analysis of studies based on the guidelines outlined in the PRISMA statement. Accordingly, maternal exposure to paracetamol during pregnancy was associated with a significant increased risk of asthma: crude OR = 1.34, 95% CI: 1.22 to 1.48, p < 0.001; and significant increased risk of wheeze: crude OR = 1.31, 95% CI: 1.12 to 1.54, p < 0.002. Results of our study confirmed that maternal paracetamol use in pregnancy is associated with an enhanced risk of asthma and wheezing in their children. We believe paracetamol should be used with caution by pregnant women, and at the lowest effective dose, and for the shortest duration. Long-term use or the use of high doses should be limited to the indications recommended by a physician and with the mother-to-be under constant supervision.
Does PLEX® Elite 9000 OCT Identify and Characterize Most Posterior Pole Lesions in Highly Myopic Patients?
Authors: Arlanzon-Lope Pablo , Campos Miguel Angel. , Fernandez-Bueno Ivan , Coco-Martin Rosa M.
Published: February 2023

High myopia (HM) is defined as an axial length (AL) ≥ 26 mm that may result in various pathologies that constitute pathologic myopia (PM). The PLEX® Elite 9000 (Carl Zeiss AC, Jena, Germany) is a new swept-source optical coherence tomography (SS-OCT) underdevelopment that allows wider, deeper and more detailed posterior-segment visualization; it can acquire ultra-wide OCT angiography (OCTA) or new ultra-wide high-density scans in one image. We assessed the technology’s ability to identify/characterize/quantify staphylomas and posterior pole lesions or image biomarkers in highly myopic Spanish patients and estimate the technology’s potential to detect macular pathology. The instrument acquired 6 × 6 OCTA, 12 × 12 or 6 × 6 OCT cubes, and at least two high-definition spotlight single scans. A hundred consecutive patients (179 eyes; age, 51.4 ± 16.8 years; AL, 28.8 ± 2.33 mm) were recruited in one center for this prospective observational study. Six eyes were excluded because images were not acquired. The most common alterations were perforating scleral vessels (88.8%), classifiable staphyloma (68.7%), vascular folds (43%), extrafoveal retinoschisis (24%), dome-shaped macula (15.6%), and more uncommonly, scleral dehiscence (4.46%), intrachoroidal cavitation (3.35%), and macular pit (2.2%). The retinal thickness of these patients decreased, and the foveal avascular zone increased in the superficial plexus compared with normal eyes. SS-OCT is a novel potent tool that can detect most main posterior pole complications in PM and may provide us with a better understanding of the associated pathologies; some pathologies were identifiable only with this new kind of equipment, such as perforating scleral vessels, which seem to be the most common finding and not so frequently related to choroidal neovascularization, as previously reported.
The Effects of Novel Pulsed Electromagnetic Field Therapy Device on Acute Distal Radius Fractures: A Prospective, Double-Blind, Sham-Controlled, Randomized Pilot Study
Authors: Factor Shai , Druckmann Ido , Atlan Franck , Rosenblatt Yishai , Tordjman Daniel , Krespi Raphael , Kazum Efi , Pritsch Tamir , Eisenberg Gilad
Published: February 2023

Background: this pilot study aimed at determining whether the application of a novel new method of generating pulsed electromagnetic field (PEMF), the Fracture Healing Patch (FHP), accelerates the healing of acute distal radius fractures (DRF) when compared to a sham treatment. Methods: 41 patients with DRFs treated with cast immobilization were included. Patients were allocated to a PEMF group (n = 20) or a control (sham) group (n = 21). All patients were assessed with regard to functional and radiological outcomes (X-rays and CT scans) at 2, 4, 6 and 12 weeks. Results: fractures treated with active PEMF demonstrated significantly higher extent of union at 4 weeks as assessed by CT (76% vs. 58%, p = 0.02). SF12 mean physical score was significantly higher in PEMF treated group (47 vs. 36, p = 0.005). Time to cast removal was significantly shorter in PEMF treated patients, 33 ± 5.9 days in PEMF vs. 39.8 ± 7.4 days in sham group (p = 0.002). Conclusion: early addition of PEMF treatment may accelerate bone healing which could lead to a shorter cast immobilization, thus allowing an earlier return to daily life activities and work. There were no complications related to the PEMF device (FHP).
Evaluation of Antidiabetic Effect of Luteolin in STZ Induced Diabetic Rats: Molecular Docking, Molecular Dynamics, In Vitro and In Vivo Studies
Authors: Kahksha  , Alam Ozair , Al-Keridis Lamya Ahmed , Khan Jalaluddin , Naaz Sameena , Alam Afshar , Ashraf Syed Amir , Alshammari Nawaf , Adnan Mohd , Beg Md Amjad
Published: February 2023

Despite the existence of modern antidiabetic medications, diabetes still affects millions of individuals worldwide, with a high death and disability rate. There has been a concerted search for alternative natural medicinal agents; luteolin (LUT), a polyphenolic molecule, might be a good choice, both because of its efficacy and because of it having fewer side effects, compared to conventional medicines. This study aims to explore the antidiabetic potential of LUT in diabetic rats, induced by streptozotocin (STZ; 50 mg/kg b.w.), intraperitoneally. The level of blood glucose, oral glucose tolerance test (OGTT), body weight, glycated hemoglobin A1c (HbA1c), lipidemic status, antioxidant enzymes, and cytokines were assessed. Also, its action mechanism was explored through molecular docking and molecular dynamics simulations. Oral supplementation of LUT for 21 days resulted in a significant decrease in the blood glucose, oxidative stress, and proinflammatory cytokine levels, and modulated the hyperlipidemia profile. LUT also ameliorated the tested biomarkers of liver and kidney function. In addition, LUT markedly reversed the damage to the pancreas, liver, and kidney cells. Moreover, molecular docking and molecular dynamics simulations revealed excellent antidiabetic behavior of LUT. In conclusion, the current investigation revealed that LUT possesses antidiabetic activity, through the reversing of hyperlipidemia, oxidative stress, and proinflammatory status in diabetic groups. Therefore, LUT might be a good remedy for the management or treatment of diabetes.
In-Vitro Evaluation of Photofunctionalized Implant Surfaces in a High-Glucose Microenvironment Simulating Diabetics
Authors: Kheur Supriya , Kheur Mohit , Madiwal Vaibhav , Sandhu Ramandeep , Lakha Tabrez , Rajwade Jyutika , Eyüboğlu Tan Fırat , Özcan Mutlu
Published: February 2023

The present study aimed to assess the efficacy of photofunctionalization on commercially available dental implant surfaces in a high-glucose environment. Discs of three commercially available implant surfaces were selected with various nano- and microstructural alterations (Group 1—laser-etched implant surface, Group 2—titanium–zirconium alloy surface, Group 3—air-abraded, large grit, acid-etched surface). They were subjected to photo-functionalization through UV irradiation for 60 and 90 min. X-ray photoelectron spectroscopy (XPS) was used to analyze the implant surface chemical composition before and after photo-functionalization. The growth and bioactivity of MG63 osteoblasts in the presence of photofunctionalized discs was assessed in cell culture medium containing elevated glucose concentration. The normal osteoblast morphology and spreading behavior were assessed under fluorescence and phase-contrast microscope. MTT (3-(4,5 Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and alizarin red assay were performed to assess the osteoblastic cell viability and mineralization efficiency. Following photofunctionalization, all three implant groups exhibited a reduced carbon content, conversion of Ti4+ to Ti3+, increased osteoblastic adhesion, viability, and increased mineralization. The best osteoblastic adhesion in the medium with increased glucose was seen in Group 3. Photofunctionalization altered the implant surface chemistry by reducing the surface carbon content, probably rendering the surfaces more hydrophilic and conducive for osteoblastic adherence and subsequent mineralization in high-glucose environment.
Use of Robot-Assisted Ankle Training in a Patient with an Incomplete Spinal Cord Injury: A Case Report
Authors: Koseki Kazunori , Takahashi Kazushi , Yamamoto Satoshi , Yoshikawa Kenichi , Abe Atsushi , Mutsuzaki Hirotaka
Published: February 2023

Rehabilitation interventions are crucial in promoting neuroplasticity after spinal cord injury (SCI). We provided rehabilitation with a single-joint hybrid assistive limb (HAL-SJ) ankle joint unit (HAL-T) in a patient with incomplete SCI. The patient had incomplete paraplegia and SCI (neurological injury height: L1, ASIA Impairment Scale: C, ASIA motor score (R/L) L4:0/0, S1:1/0) following a rupture fracture of the first lumbar vertebra. The HAL-T consisted of a combination of ankle plantar dorsiflexion exercises in the sitting position, knee flexion, and extension exercises in the standing position, and stepping exercises in the standing position with HAL assistance. The plantar dorsiflexion angles of the left and right ankle joints and electromyograms of the tibialis anterior and gastrocnemius muscles were measured and compared using a three-dimensional motion analyzer and surface electromyography before and after HAL-T intervention. Phasic electromyographic activity was developed in the left tibialis anterior muscle during plantar dorsiflexion of the ankle joint after the intervention. No changes were observed in the left and right ankle joint angles. We experienced a case in which intervention using HAL-SJ induced muscle potentials in a patient with a spinal cord injury who was unable to perform voluntary ankle movements due to severe motor–sensory dysfunction.
Functional Activity in the Effect of Transcranial Magnetic Stimulation Therapy for Patients with Depression: A Meta-Analysis
Authors: Deng Yongyan , Li Wenyue , Zhang Bin
Published: February 2023

Depression is a long-lasting mental disorder that affects more than 264 million people worldwide. Transcranial magnetic stimulation (TMS) can be a safe and effective choice for the treatment of depression. Functional neuroimaging provides unique insights into the neuropsychiatric effects of antidepressant TMS. In this meta-analysis, we aimed to assess the functional activity of brain regions caused by TMS for depression. A literature search was conducted from inception to 5 January 2022. Studies were then selected according to predetermined inclusion and exclusion criteria. Activation likelihood estimation was applied to analyze functional activation. Five articles were ultimately included after selection. The main analysis results indicated that TMS treatment for depression can alter the activity in the right precentral gyrus, right posterior cingulate, left inferior frontal gyrus and left middle frontal gyrus. In resting-state studies, increased activation was shown in the right precentral gyrus, right posterior cingulate, left inferior frontal gyrus and left superior frontal gyrus associated with TMS treatment. In task-related studies, clusters in the right middle frontal gyrus, left sub-gyrus, left middle frontal gyrus and left posterior cingulate were hyperactivated post-treatment. Our study offers an overview of brain activity changes in patients with depression after TMS treatment.
A Multi-Task Convolutional Neural Network for Semantic Segmentation and Event Detection in Laparoscopic Surgery
Authors: Marullo Giorgia , Tanzi Leonardo , Ulrich Luca , Porpiglia Francesco , Vezzetti Enrico
Published: February 2023

The current study presents a multi-task end-to-end deep learning model for real-time blood accumulation detection and tools semantic segmentation from a laparoscopic surgery video. Intraoperative bleeding is one of the most problematic aspects of laparoscopic surgery. It is challenging to control and limits the visibility of the surgical site. Consequently, prompt treatment is required to avoid undesirable outcomes. This system exploits a shared backbone based on the encoder of the U-Net architecture and two separate branches to classify the blood accumulation event and output the segmentation map, respectively. Our main contribution is an efficient multi-task approach that achieved satisfactory results during the test on surgical videos, although trained with only RGB images and no other additional information. The proposed multi-tasking convolutional neural network did not employ any pre- or postprocessing step. It achieved a Dice Score equal to 81.89% for the semantic segmentation task and an accuracy of 90.63% for the event detection task. The results demonstrated that the concurrent tasks were properly combined since the common backbone extracted features proved beneficial for tool segmentation and event detection. Indeed, active bleeding usually happens when one of the instruments closes or interacts with anatomical tissues, and it decreases when the aspirator begins to remove the accumulated blood. Even if different aspects of the presented methodology could be improved, this work represents a preliminary attempt toward an end-to-end multi-task deep learning model for real-time video understanding.
No Differences in Rotational Thromboelastometry Measurements between Portal and Peripheral Circulation in Cirrhotic Patients Undergoing TIPS
Authors: Bedreli Sotiria , Manka Paul , Buechter Matthias , Jahn Michael , Theysohn Jens M. , Canbay Ali , Katsounas Antonios
Published: February 2023

Background: In patients with liver cirrhosis, transjugular intrahepatic portosystemic shunt (TIPS) is considered a standardized treatment of refractory ascites or variceal bleeding. TIPS thrombosis (TT) and/or portal vein thrombosis (PVT) are possible complications during/after TIPS placement. Previous studies suggested increased clotting activity in portal circulation (PORC). This pilot study aimed to evaluate alterations and differences of coagulation function in PORC and in peripheral circulation (PERC) via rotational thromboelastometry during TIPS. Methods: Blood samples were collected from cirrhotic patients (n = 13; median Model of End Stage Liver Disease, MELD Score: 12; median age: 60 years) undergoing TIPS (10/13 TIPSs were elective procedures due to refractory ascites) as follows: median cubital vein (MCV; PERC)—confluence of the three hepatic veins to the inferior cava vein (HV/ICV; PORC)—portal vein (PV; PORC)—TIPS (PORC). This research utilized four variables of the extrinsic test EXTEM, i.e., clotting time (CT), clot formation time (CFT), maximum clot firmness (MCF), and maximum lysis (ML). Results: EXTEM results [mean, M (range) ± standard deviation, SD (range)] showed no significant differences for CT [M (70–73) ± SD (9–13); p = 0.93] or CFT [M (137–155) ± SD (75–112); p = 0.97] or MCF [M (51–54) ± SD (9–10); p = 0.90] or ML [M (9–10) ± SD (4–5); p = 0.89] between the compartments, i.e., MCV vs. HV/ICV vs. PV vs. TIPS. Overall, we detected no differences in coagulation function between PERC and PORC. Conclusion: These results are in contrast to previous reports suggesting increased clotting activity in PORC vs. PERC in association with liver cirrhosis. Rotational thromboelastometry-based evaluation of coagulation function in PERC appears to reliably reflect coagulation function in PORC with respect to risk estimation for TT and/or PVT in cirrhotic patients undergoing TIPS.
Influence of Landscape Characteristics on Wind Dispersal Efficiency of Calotropis procera
Authors: Menge Enock O. , Lawes Michael J.
Published: February 2023

Rubber bush (Calotropis procera), a perennial invasive milkweed, infests large swathes of pastoral land in northern Australia and Queensland, diminishing pasture productivity. The seeds of rubber are small with fluffy pappi that confer buoyancy during wind dispersal. Long-distance seed dispersal (LDD) by wind is dependent in part on seed terminal velocity, the height of release above the ground, the surrounding vegetation, and wind parameters such as speed and vertical turbulence. Using empirical dispersal data, spatial population distribution, and historical knowledge of three experimental sites, we examine how seed traits can interact with environmental features to promote dispersal. We expected naturalised rubber bush populations to have the following: (1) higher spatial autocorrelation on open plains where dispersal distances are maximised compared to hilly habitats or those with tall vegetation; (2) southeast to northwest directional bias aligned to prevailing winds; and (3) patchy satellite populations ahead of an infilled continuous main front. Seed dispersal kernels were estimated by releasing seeds from dehiscent fruit for four periods of ten minutes each at three locations from a fixed height while monitoring wind speed. Five alternative models were fitted to the seed dispersal data, of which the log-logistic (Kolgomorov–Smirnov test p = 0.9998), 3-parameter Weibull model (K-S p = 0.9992), and Weibull model (K-S p = 0.9956) provided the best fit in that order. Stem size distribution was similar at the leading edges of populations at all sites (F10, 395 = 1.54; p = 0.12). The exponential semivariogram model of the level of spatial autocorrelation was the best fit and was adopted for all sites (Tennant Creek (TC), Helen Springs (HS) and Muckaty (MU) sites (R2 = 63.8%, 70.3%, and 93.7%, respectively). Spatial autocorrelation along the predicted southeast-to-northwest bearing was evident at all sites (TC kriging range = 236 m; HS = 738 m and MU = 1779.8 m). Seed dispersal distance was bimodal and dependent on prevailing wind conditions, with short distance dispersal (SDD) up to 55 m, while the furthest propagules were 1.8 km downwind in open environments. Dispersal directions and distances were pronounced on plains with short or no vegetation, compared to hilly locations or areas with tall vegetation. In designing management strategies, it should be noted that invasion risk is greater in frequently disturbed open landscapes, such as pastoral landscapes in Northern Australia. Infestations on open xeric grassland plains with shrubby vegetation should be a priority for rubber bush control to maintain high levels of productivity in beef production systems.
The Longevity of Fruit Trees in Basilicata (Southern Italy): Implications for Agricultural Biodiversity Conservation
Authors: Palli Jordan , Baliva Michele , Biondi Franco , Calcagnile Lucio , Cerbino Domenico , D’Elia Marisa , Muleo Rosario , Schettino Aldo , Quarta Gianluca , Sassone Nicola , Solano Francesco , Zienna Pietro , Piovesan Gianluca
Published: February 2023

In the Mediterranean basin, agriculture and other forms of human land use have shaped the environment since ancient times. Intensive and extensive agricultural systems managed with a few cultured plant populations of improved varieties are a widespread reality in many Mediterranean countries. Despite this, historical cultural landscapes still exist in interior and less intensively managed rural areas. There, ancient fruit tree varieties have survived modern cultivation systems, preserving a unique genetic heritage. In this study, we mapped and characterized 106 living fruit trees of ancient varieties in the Basilicata region of southern Italy. Tree ages were determined through tree ring measurements and radiocarbon analyses. We uncovered some of the oldest scientifically dated fruit trees in the world. The oldest fruit species were olive (max age 680 ± 57 years), mulberry (647 ± 66 years), chestnut (636 ± 66 years), and pear (467 ± 89 years). These patriarchs hold a unique genetic resource; their preservation and genetic maintenance through agamic propagation are now promoted by the Lucan Agency for the Development and Innovation in Agriculture (ALSIA). Each tree also represents a hub for biodiversity conservation in agrarian ecosystems: their large architecture and time persistence guarantee ecological niches and micro-habitats suitable for flora and fauna species of conservation significance.
Social Use through Tourism of the Intangible Cultural Heritage of the Amazonian Kichwa Nationality
Authors: Maldonado-Erazo Claudia Patricia , del Río-Rama María de la Cruz , Andino-Peñafiel Erica Estefanía , Álvarez-García José
Published: February 2023

The traditional trend in heritage management focuses on a conservationist strategy, i.e., keeping heritage in a good condition while avoiding its interaction with other elements. This condition results in the link between heritage and tourism to be established as juxtaposed process, which gives rise to the need to broaden the concept of heritage and how it can be used through tourism to contribute to the local development of communities. The objective of this study is to show the different mechanisms of social use that the intangible cultural heritage of the different peoples and nationalities of Ecuador can have. For this purpose, the San Antonio de Killu Yaku community, parish of Puerto Napo, canton Tena, Napo province, is taken as a case study, based on an analysis of the current situation of tourism in the community. The cultural resources of the territory are taken as a starting point to transform them into tourist attractions for the construction of a thematic heritage space, in order to minimize the concern about the erosion and lack of appreciation of the ancestral manifestations and knowledge that the nationality possesses, due to the accelerated globalization of society. The analysis corresponds to a descriptive process of all the information collected with the proposed exploitation mechanisms through tourism activities. During the process, an increase in the exchange of knowledge was shown, as well as a constant cultural insurgency in which people maintain themselves to safeguard their cultures.
Exploring Farmers’ Decisions on Agricultural Intensification and Cropland Expansion in Ethiopia, Ghana, and Zambia through Serious Gaming
Authors: Adolph Barbara , Jellason Nugun P. , Kwenye Jane Musole , Davies Jo , Dray Anne Giger , Waeber Patrick O. , Jeary Katy , Franks Phil
Published: February 2023

This paper explores how increasing agricultural productivity through agricultural intensification may influence farmland expansion decisions of smallholder farmers in Ethiopia, Ghana, and Zambia. Six pairs of farmers at each site (72 in total) from different wealth groups were involved in serious games sessions that simulated different institutional, economic, and governance contexts, with players choosing their resource allocation accordingly. The approach was used to explore with farmers, in a ‘safe space’, whether an increase in agricultural productivity and profitability via intensification would reduce or end farmland expansion into natural habitats. The results show that, under certain conditions (such as poor forest governance and lack of alternative income-generating and investment opportunities), agricultural intensification can lead to more agricultural expansion at the expense of natural habitats, such as forests and grasslands. This suggests that intensification strategies to promote increased productivity may need companion strategies to protect forest ecosystems from expansion at the agricultural frontier.
Detecting the Spatial Network Structure of the Guanzhong Plain Urban Agglomeration, China: A Multi-Dimensional Element Flow Perspective
Authors: Meng Bao , Zhang Jifei , Zhang Xiaohui
Published: February 2023

Element flow has gradually become an important method for studying urban spatial structure. This study examined 11 prefectural cities in the Guanzhong Plain urban agglomeration; constructed a measurement model for information, traffic, migration, and composite networks; and analyzed the spatial structure of the urban network of the urban agglomeration through social network analysis and spatial visualization. The spatial structure of the composite flow network had Xi’an as the center and Xianyang, Baoji, Weinan and Tianshui as important nodes; Yuncheng, Linfen and Qingyang were the secondary nodes, radiating to the surrounding three cities. Element flow connection strength was unbalanced, and only three city pairs were in the first level of the composite flow network. Network density was low-middle, and the network connection was weak. Xi’an was the primary central city of the Guanzhong Plain urban agglomeration with the strongest agglomeration and radiation capabilities; it could communicate with other cities without intermediate cities and was a bridge for other cities. Tongchuan, Pingliang, Shangluo, and Qingyang were at the edge of the urban agglomeration and had weak agglomeration, radiation, and intermediary capabilities. The inner cities of cohesive subgroups were closely related with weak connections between subgroups. The single-polarization of the Guanzhong Plain urban agglomeration was serious, and the single-core spatial structure centered on Xi’an had limited impact on the urban agglomeration. Development of small and medium-sized cities should be strengthened in the future.
Contemporary Review of Multi-Modality Cardiac Imaging Evaluation of Infective Endocarditis
Authors: Arockiam Aro Daniela , Agrawal Ankit , El Dahdah Joseph , Honnekeri Bianca , Kafil Tahir S. , Halablab Saleem , Griffin Brian P. , Wang Tom Kai Ming
Published: February 2023

Infective endocarditis (IE) remains to be a heterogeneous disease with high morbidity and mortality rates, which can affect native valves, prosthetic valves, and intra-cardiac devices, in addition to causing systemic complications. The combination of clinical, laboratory, and cardiac imaging evaluation is critical for early diagnosis and risk stratification of IE. This can facilitate timely medical and surgical management to improve patient outcomes. Key imaging findings for IE include vegetations, valve perforation, prosthetic valve dehiscence, pseudoaneurysms, abscesses, and fistulae. Transthoracic echocardiography continues to be the first-line imaging modality of choice, while transesophageal echocardiography subsequently provides an improved structural assessment and characterization of lesions to facilitate management decision in IE. Recent advances in other imaging modalities, especially cardiac computed tomography and 18F-fluorodeox-yglucose positron emission tomography, and to a lesser extent cardiac magnetic resonance imaging and other nuclear imaging techniques, have demonstrated important roles in providing complementary IE diagnostic and prognostic information. This review aims to discuss the individual and integrated utilities of contemporary multi-modality cardiac imaging for the assessment and treatment guidance of IE.
Relationships between Easily Available Biomarkers and Non-Dipper Blood Pressure Pattern in Patients with Stable Coronary Artery Disease
Authors: Drugescu Andrei , Roca Mihai , Zota Ioana Mădălina , Costache Alexandru-Dan , Leon-Constantin Maria-Magdalena , Gavril Oana Irina , Gavril Radu Sebastian , Vasilcu Teodor Flaviu , Mitu Ovidiu , Ghiciuc Cristina Mihaela , Mitu Florin
Published: February 2023

Introduction. Chronic inflammation plays an essential role in the pathophysiology of both arterial hypertension (HTN) and coronary artery disease (CAD), and is more pronounced in individuals with a non-dipper circadian blood pressure (BP) pattern. A non-dipping BP pattern is in turn is associated with increased cardiovascular morbi-mortality, and a higher risk of atherosclerotic events. Neutrophil to lymphocyte ratio (NLR), monocyte to lymphocyte ratio (MLR) and platelet to lymphocyte ratio (PLR) are readily available predictors of systemic inflammation and cardiovascular risk. The purpose of our study is to evaluate whether NLR, MLR and PLR can be used as cost-effective predictors of a non-dipping blood pressure pattern in hypertensive patients with stable CAD. Materials and Methods: We performed a cross-sectional retrospective analysis that included 80 patients with hypertension and stable CAD (mean age 55.51 ± 11.83 years, 71.3% male) referred to a cardiovascular rehabilitation center. All patients underwent clinical examination, 24 h ambulatory blood pressure monitoring (ABPM) and standard blood analysis. Results: Baseline demographic characteristics were similar in both groups. Patients with non-dipper pattern had significantly higher NLR (median = 2, IR (2–3), p < 0.001), MLR (median = 0.31, IR (0.23–0.39), p < 0.001) and PLR (median = 175, IR (144–215), p < 0.001) compared to dippers. Conclusion: Our results suggest that MLR and PLR are inexpensive and easily accessible biomarkers that predict a non-dipping pattern in hypertensive patients with stable CAD.
Effects of Temperature and Humidity on Soil Gross Nitrogen Transformation in a Typical Shrub Ecosystem in Yanshan Mountain and Hilly Region
Authors: Hu Xiaoxia , Zhang Yuanxun , Wang Dong , Ma Jian , Xue Kaibing , An Zhaobo , Luo Wenxing , Sheng Yizhi
Published: February 2023

Shrubland is a pivotal terrestrial ecosystem in China. Soil nitrogen transformations play a crucial role in maintaining the productivity of this ecosystem, yet the driving forces underlying it have not been sufficiently addressed, particularly under ongoing climate changes. Herein, by incorporating 15N isotope pool dilution method in laboratory incubation, the rates of gross N ammonification, nitrification, and inorganic N consumption in soils in response to varying temperature and humidity conditions were determined at different depths (SL10: 0–10 cm, and SL20: 10–20 cm) in a typical shrub ecosystem in the Yanshan mountain and hilly region, North China. The gross rates of ammonification and nitrification of soils in SL10 were higher than those in SL20, which was likely affected by the higher soil organic matter and total N contents at a shallower depth. Both temperature and humidity significantly affected the N transformations. The gross ammonification and nitrification were significantly stimulated as the incubation temperature increased from 5 to 35 °C. The gross ammonification increased exponentially, while the gross nitrification increased differently in different temperature ranges. The increment of soil water contents (from 30% WHC to 60% and 100% WHC) promoted the gross nitrification rate more significantly than the gross ammonification rate. The gross nitrification ceased until soil water content reached 60%WHC, indicating that soil water availability between 60% and 100% WHC was not a limiting factor in the nitrification process for the shrubland soils in this study. The ammonium (NH4+) immobilization was significantly lower than nitrification irrespective of varying environmental conditions, even though the NH4+ consumption rate might be overestimated, uncovering two putative processes: (1) heterotrophic nitrification process; (2) and more competitive nitrifying bacteria than NH4+-immobilizing microorganisms. Our study is indispensable for assessing the stability and sustainability of soil N cycling in the shrub ecosystem under climate changes.