bluuebunny/crossref_metadata_2025 huggingface dataset:
Bioefficacy of diflubenzuron against subterranean termite
Authors: Aparna Kalawate
Published: April 2023

BACKGROUD & OBJECTIVE: Subterranian termite is a structure-infesting termite that accounts for a significantproportion of the damage wherever it occurs. One sustainable control strategy that usually helps to reduce the damage ofsubterranean termite is the use of insecticides which are safe to the environment. Hence, bioefficacy study ofdiflubenzuron, an environ friendly, chitin synthesis inhibitor was evaluated against subterranean termite.METHODOLOGY: It was achieved by testing by testing the three different concentrations of diflubenzuron againstsubterranean termite as per IS 4873. RESULTS: Diflubenzuron was found to be effective against subterranean termite.CONCLUSION: From the results of this study, it has been found that diflubenzuron at 1% concentration rate providedexcellent control of termite. This is the first report on the use of diflubenzuron in the glue line to control the termite.
Neutral α-mannosidase from fungus Aspergillus fischeri (NCIM 508) belongs to Class IIC subfamily
Authors: Shashidhara KS  , Prashanth Kumar HP  , Sameer Srivastava  , Gaikwad SM
Published: April 2023

BACKGROUD & OBJECTIVE: The α-mannosidase gene from Aspergillus fischeri was isolated by DNA and RNAmethod. METHODOLOGY: Cloning of gene, isolation of recombinant plasmid and sequencing of gDNA gene wascarried out and bioinformatic analysis was done for gene to get intron-exon information and for sequence homology.RESULTS:The α-mannosidase gene from Aspergillus fischeri is 1990 base pair long and sequence analysis showedpresence of three introns and four exons in the gene. BLAST analysis revealed 100% similarity to the Neosartoryafischeri (A. fischeri) and 94% with Aspergillus fumigatus class I α-mannosidase reported in NCBI Gene Data Bank.CONCLUSION: The neutral α-mannosidase from Aspergillus fischeri could belong to the Class IIC subfamily.
To study the mode and mechanism of interaction of Angiopoietin II with receptor tyrosine kinase Tie-2 using molecular mechanics and molecular dynamics approach
Authors: Manya Sharma  , Pradeep Kumar Naik
Published: April 2023

BACKGROUD & OBJECTIVE: Angiopoietins are protein growth factors which play key role in Angiogenesis.Angiogenesis is the process of forming blood vessels from pre-existing ones. Angiopoietin-1 (Ang-1) and Angiopoietin-2 (Ang-2) have been identified as ligands of the endothelial receptor tyrosine kinase Tie-2. ANG-2 is a key regulator ofangiogenesis that exerts context-dependent effects on endothelial cell (ECs). ANG-2 binds the endothelial-specificreceptor TIE2 and acts as a negative regulator of ANG-1/TIE2 signaling during angiogenesis, thereby controlling theresponsiveness of ECs to exogenous cytokines. The transmembrane tyrosine kinase TIE-2 and the receptor forangiopoietins have been shown to be involved in angiogenic processes. They are also known to play a role in tumorangiogenesis. However, the mode of interactions between ANG-2 and TIE2 receptor is not known because of theabsence of high resolution co-crystal structure. Therefore in this study attempts were made to investigate the mode andmechanism of molecular interactions between Tie2 with Ang2 using molecular modeling and molecular dynamicsstudies. METHODOLOGY: In the present study, both Tie2 (PDB Id: 2GY5) and Angiopoietins (PDB Id: 2GY7) werefirst prepared using protein preparation wizard (Schrodinger package). Protein-protein interaction between both theproteins was studied using ZDock followed by refinement using Rdock. The best docked pose was then subjected toMolecular dynamics (MD) simulations to study the precise interaction between TIE2 (Receptor) and Angiopoietin-2(Ligand) over a specific time span using AMBER 11.0. The obtained MD trajectories were further used to estimate thebinding free energy of the complex using the molecular mechanics/Poisson Boltzmann surface area (MM-PBSA)method. RESULTS: The binding energy (∆Gbinding) between both the proteins, Tie2 and Ang2 was predicted to be -28.77kcal/mol using Rdock. The other energy parameters between Tie2 and APC interactions such as electrostatic (Eelec), vander Waals (Evdw) and desolvation (Esol) energy are -44.68 kcal/mol, -99.83 kcal/mol and 6.10 kacal/mol respectively,demonstrating modest interactions between them. The interacting surface area between Tie2 and Ang2 is 842:858Å2.CONCLUSION: Results obtained from this study revealed that both Ang2 and Tie2 bind with high affinity with modestinteracting surface area. Further the results guided us in designing specific experiments for biological evaluations.
Knowledge, Attitude And Practices Regarding Tuberculosis Among Treatment Partners Attending Urban Health Care Centre, KMC, Mangalore-A Cross-Sectional Study
Authors: Sanam Jindal
Published: April 2023

Background and Objective : This study aims to describe the knowledge, attitudes and practices towards tuberculosis (TB) amongtreatment partners seen at the out-patient department (OPD) of the Lady Hill Urban Health Care Centre, KMC, Mangalore fromApril to May 2009. Methodology: A questionnaire-based survey was conducted to investigate the knowledge, attitudes andpractices towards TB among treatment partners (age more than 12 years old; pediatric age group was excluded) seen at the OPD. Apre-validated questionnaire, which consisted of 20 questions, was distributed to treatment partners of these patients. Results: Outof the 184 respondents, 154 (83.70%) were aware of and had good knowledge about TB. Eighty-one percent of the respondentshad acceptable attitudes and practices toward the disease. 96% were aware that TB is a highly infectious disease, while 79.3%believed that it is a curable disease. The main source of information about tuberculosis was the mass media (newspapers, televisionand radio) in 42.5% of the respondents. In the survey, only 16.3% patients were aware about DOTS and only 42.4% knew aboutfree treatment services. Conclusion: There is still a need to strengthen the educational activities on TB through mass media; theyare excellent venues for information-dissemination, thus, leading to better case detection.
Noscocomial Infections: A brief Review
Authors: Ashish Chauhan  , Bharti Mittu  , Priyanka Chauhan
Published: April 2023

Many patients around the world suffer harm due to infections caused by viruses, bacteria, fungi, protozoa or helminthes that are nolonger susceptible to the common medicines used to treat them. Reports are most often generated on the basis of laboratory resultson microbes obtained from human patients. Nosocomial is one such common infection through-out the world. It is an infectionwhose growth and development is favored by hospital environment. This review elaborates the details of this infections in brief.The review presents its various types, bio-medical classification, pathogen responsible, effective antibiotics against this infection,antibiotic resistance in patients and general guidelines. This concise information could be useful for further research, bio-medicalapplications, disease management, pharmacy practice, drug administration and exploring the efficacious drug to treat the patient.
Antioxidant and nutraceutical potential of bamboo: an overview
Authors: Arvind Kumar Goyal  , Birendra Kumar Brahma
Published: April 2023

The mention of the traditional use of bamboo in Asian medicine dates back to the 6th century. Today people are switching overthe use of herbal medicine instead of the synthetic drugs and bamboo, the ‘Green gold’ has voluminous nutraceutical propertiesand thus forms a core ingredient for research in many laboratory. Scientists from round the globe are exploring bamboo forestablishing its pharmacological mechanism and also record the individual constituents responsible for it. This reviewsummarizes published information on the historical uses, nutritional composition of various parts together with theantioxidative potential and the possible role and mechanism of action of these phytochemical components with regards to theantimicrobial, anti-diabetic, anti-cancer, anti-inflammatory, anti-obesity, anti-fatigue, anti-lipidemic effect along with effects onthe cardiovascular diseases of this ‘Green gold’.
miRNA Database: A database on miRNA expressions in cell lines
Authors: Narayanaswamy RamachandraSwam  , DyaveGowda Padmashree
Published: April 2023

miRNAs are small non-coding RNA molecules which regulate the gene expression at translational and post-transcriptional level bytargeting mRNA. In today’s world miRNA have enormous role in various functions which involves vertebrates, invertebrates,plants and viruses etc., to know the importance of each miRNA candidates in human and mice, we designed this database called asmiRNA Database, which integrate the data from various sources and explain functions of each miRNA candidate and theirexpressions in cell lines. Currently miRNA Database gives the information of 100 miRNA lists and expression in different celltypes. Future approach: We are going to incorporate some of the remaining miRNAs and also update the existing miRNAs list.
Effect of biological and chemical elicitors on the photosynthetic pigments and antioxidant activities of Withania somnifera
Authors: Veena Pande  , Nitin Kumar Sharma  , Mayank Pandey
Published: April 2023

Background & aim: Withania somnifera, popularly known as Aswagandha has an immense value in Ayurveda. In the presentstudy we aimed to evaluate the Effect of different elicitors on the photosynthetic pigments and antioxidant activities of Withaniasomnifera. Methods: The seeds of W. somnifera were subjected to elicitors before sowing. Both the controlled as well as treatedplants were subjected to various biochemical analysis using standard methods. Results & conclusion: The chlorophyll, carotenoid,phenol, flavonoid, proline contents were found to be higher in elicitor treated plants compared to control. Among those treatedwith elicitor, plants treated with Pseudomonas flourescens showed the great increase in the phenolic and flavonoid contents,proving it to be a better elicitor.
Probiotics for Oral Health: An Upcoming Natural Way Forward
Authors: Mukut Seal  , RadhikaManiyar  , KartikPendharkar
Published: April 2023

The oral infections and tooth decay are now-a-day a common disease. This occurs mainly due to changes inenvironment by way of illness debility, diet, medication etc. To prevent this, an effective treatment by antimicrobialtherapy is in use, but some side effects are associated with this treatment. Hence, the researchers are searching forother alternative treatment of dental infection. One such alternative treatment is use of Probiotics which is apromising way to fight infections by using harmless bacteria. These products help in protecting health by promotingflora and also suppressing the pathogens. Various studies revealed anti-cariogenic effects of probiotics and their usein the treatment of periodontal diseases. However, an actual result on the use of probiotics for the treatment of oralcavity is still waited. The present review is an attempt in brief to focus the potential role of probiotics in improvingoral and dental health.
A pilot sero-survey for surra in livestock in Karnataka by ELISA using flagellar antigen of Trypanosoma evansi
Authors: Ligi Jose  , Sengupta P. P  , Rudramurthy G. R  , Rahman H
Published: April 2023

Background: Trypanosoma evansi causes trypanosomosis or ‘surra’ in domestic and wild animals and is transmittedby haematophagus tabanid fly. For successful control of the disease, it is important to detect the carrier animalsfollowed by successive treatment. For this purpose a reliable serological test is useful for mass screening of theanimals. Methodology: In the present study, emphasis was given to address the need for the development of a massscreening serological test by using purified flagellar antigen of T. evansi for the detection of antibody against surra.Also a pilot sero-epidemiological study for trypanosomosis in different species using purified flagellar (FLA) antigenbased indirect enzyme linked immunosorbant assay (I-ELISA) was conducted and compared with standard CATT/T.evansi test. The diagnostic potentiality of purified FLA antigen based I-ELISA (FLA-I-ELISA) was evaluated using197 sera samples from field animals including cattle, buffaloes, horses and donkeys. Results: The test showed anoverall 14.72% sero positivity (S.P). Among cattle, S.P was found to be 18.03%, in buffalo 25%, in horse 6.25% andin donkeys 5.5%. Conclusion: Thus, epidemiological survey were done with purified FLA antigen based I-ELISAtest in Karnataka reveals that, buffalo samples showed the maximum sero positivity for trypanosomosis.
Android Based Application for Searching Indekos In Pasar Minggu Jakarta South With Location Based Service (LBS) Method
Authors: Fauzan Farhan , Faizah NM , Koryanto Lucky
Published: April 2023

Often the availability of the number of boarding houses is not comparable to the number of boarding house seekers, so boarding seekers must find information more quickly in order to get a place to live according to what they want. Boarding house owners promote their boarding houses in a conventional way, namely by word of mouth, distributing brochures, or posting announcements in public places. Based on these problems, an Android-based boarding house search application is needed, an application system that can be a place for out-of-towners who feel confused in finding boarding houses that suit their wishes, and can help boarding owners promote their boarding houses online via a smartphone based on android. The research objective was to design a boarding house search application in Pasar Minggu, South Jakarta, the method used was the waterfall methodology, which is a system method that begins with the requirements analysis stage, then system design, implementation of application development, and users are carried out. This application system was developed using the Java programming language and utilizing Location Based Services and Google Maps. The results of the research resulted in a boarding house search application that makes it easier for users to find boarding houses according to their needs and also this application can provide information about boarding facilities and this application can also make it easier for boarding house owners to publish their boarding houses.
Reimbursement Application Using Rest API Methods and Android-Based Flutter Framework (Case Study: PT. Protonema)
Authors: Renardi Febby , Faizah NM , Koryanto Lucky
Published: April 2023

PT. Protonema is a company engaged in the field of information technology, namely as a consulting partner in Jakarta. This company has provided various kinds of facilities to employees to support their work and simultaneously to improve their quality of life who are concerned about the importance of self-development and provide health insurance. Employees can submit claims to obtain these facilities by attaching receipts as further evidence that the company reimburses the costs that have been incurred, this is often referred to as reimbursement. Submission of reimbursement by employees based on the current process has problems, such as the absence of notification of claims submitted by employees whether the claim is accepted or rejected and still using Microsoft Word which is eventually printed into this archive, it is feared that it will be lost or forgot to save it because scattered archives. The purpose of writing this research is to produce an Android-based reimbursement submission application at PT. Protonema with the REST (Representational state transfer) API (Application Programming Interface) method as a data exchange medium and supported by MySQL so that data processing is precise and safe because it is stored in a database and other supports, namely the Flutter framework, are used to design Android applications. In making this software using the waterfall model and data collection techniques, namely observation, interviews and literature study. From this research, it can be concluded that an Android-based reimbursement application using the REST API method and supported by MySQL can help PT. Protonema in managing employee reimbursement applications more efficiently and effectively. By using this application, employees can submit reimbursement requests easily and quickly via their cellphones, and the data obtained will be recorded correctly and safely in the database. The use of the Flutter framework also helps in designing the appearance and functionality of applications that are easier to use and accessible to employees. Therefore, this application can be an effective solution to increase the efficiency and effectiveness of employee reimbursement management at PT. Protonema.
FİNANSAL RİSKLERİN SÜRDÜRÜLEBİLİR BÜYÜME VE KARLILIK ÜZERİNDEKİ ETKİLERİ: BIST100 ENDEKSİ FİRMALARI ÜZERİNE BİR UYGULAMA
Authors: YAMAN Serdar , GÜR Kevser Esra
Published: April 2023

Bu çalışmada, finansal risklerin firmaların karlılık ve sürdürülebilir büyümeleri üzerindeki etkileri panel regresyon analizi ile incelenmiştir. Çalışmada Ocak 2010-Kasım 2022 dönemine BIST100 endeksinde düzenli olarak yer alan firmalara ait finansal tablo verileri kullanılmıştır. Çalışmada firmaların finansal risklerini temsilen faiz riski, kredi riski, döviz kuru riski, likidite riski ve sermaye riski kullanılmıştır. Firma karlılığını temsilen aktif karlılığı, finansal sürdürülebilirliği temsilen ise içsel büyüme, sürdürülebilir büyüme ve Higgins (1977) sürdürülebilir büyüme oranları kullanılmıştır. Çalışmada finansal risklerin karlılık ve finansal sürdürülebilirlik üzerindeki etkileri dört farklı panel regresyon modeli geliştirilerek incelenmiştir. Analizler sonucunda, finansal risklerin karlılık ve finansal sürdürülebilirlik değişkenlerindeki değişimleri istatistiki olarak anlamlı bir şekilde açıkladığı tespit edilmiştir. Regresyon analizi sonucunda, likidite riski ve sermaye riskinin karlılık üzerinde negatif etkilerinin bulunduğu; faiz riski, döviz kuru riski, likidite riski ve sermaye riskinin içsel büyüme oranı ve sürdürülebilir büyüme oranı üzerinde negatif etkilerinin bulunduğu; faiz riski ve likidite riskinin Higgins (1977) sürdürülebilir büyüme oranı üzerinde negatif, sermaye riskinin ise pozitif etkilerinin bulunduğu tespit edilmiştir. Elde edilen bulgular risk yönetiminin gerek karlılık gerekse finansal sürdürülebilirlik üzerinde önemli etkilerinin bulunduğunu göstermektedir.
La déconstruction égalitariste de la (dé)raison pédagogique chez Jacques Rancière
Authors: Auclair David
Published: April 2023

Cet article propose une lecture critique du Maître ignorant de Jacques Rancière. Devant les inégalités scolaires passées et actuelles, une question persiste et nous tenterons d’y répondre : est-ce que les processus de subjectivation des enfants doivent passer par les contraintes d’une autorité adulte ? Pour Rancière, « la vertu d’ignorance est d’abord une vertu de dissociation », c’est-à-dire que l’émancipation intellectuelle commande une séparation entre maîtrise et savoir. Le maître igno-rant n’ignore pas tout, il ignore les raisons sociales de l’inégalité. Cette posture politique est anti-institutionnelle. Seul l’individu peut s’émanciper et l’école n’a jamais émancipé personne, écrit ce philosophe. Dès lors, quelles sont les conditions sociales de l’autonomie ? Ce n’est pas sans danger que les adultes en position d’autorité se désengagent de leurs devoirs au nom d’un laisser-faire qui naturalise les rapports hors des institutions. Nous pensons que Rancière n’échappe pas à la contradiction qui conduit à empêcher l’émancipation au nom de l’égalité. Cela n’enlève rien à sa capacité d’identifier des problèmes scolaires qui semblent encore à ce jour insolubles.
Emiliano Barral-Pablo Iglesias. Análisis del Mausoleo erigido en su memoria
Authors: Guerrero Serrano Víctor
Published: April 2023

Durante su trayectoria vital, el escultor Emiliano Barral mantuvo una vinculación muy estrecha con el Partido Socialista. No en vano, fue autor del monumento funerario destinado a fijar una imagen canónica de su fundador, Pablo Iglesias. Sin embargo, la historiografía artística que previamente lo ha estudiado, no ha dado una respuesta precisa a la pregunta de en qué momento se inició la relación entre el artista y el líder socialista. En este artículo, aportamos una fuente documental esencial de cara a resolver dicha incógnita. Además de esta contribución, hemos centrado la investigación en el estudio tanto de los primeros retratos que realizó sobre su efigie, así como del Mausoleo del Cementerio Civil, obra clave y que marca un punto decisivo dentro de su producción artística. Hasta el momento actual, no se había realizado una revisión detallada del conjunto funerario. Para ello, hemos recopilado un importante número de fuentes documentales y hemerográficas, cuya lectura nos ha permitido realizar un análisis exhaustivo de la secuencia cronológica de su construcción, su estructura arquitectónica, así como de los detalles escultóricos que lo componen.
La reinterpretación del sonido de la metrópoli en las sinfonías urbanas
Authors: De Ortueta Hilberath Elena
Published: April 2023

Las sinfonías urbanas de la vanguardia cinematográfica reflejaron el pensamiento estético y filosófico del momento. La historiografía ha recalcado la trascendencia de la imagen, la técnica del montaje y el universo simbólico o el formal, pero ha desatendido, en cierta forma, el alcance de la banda sonora. El debate planteado por Schopenhauer, Valery o Benjamin sobre la percepción del ruido y del sonido fue un aspecto valorado en las composiciones musicales que buscaron la reinterpretación y la reproducción del ambiente de la metrópoli. El citadino estaba sometido a un sinfín de estímulos marcados por un ritmo frenético según Nietzsche y Simmel. Las sinfonías y documentales coetáneos inspirados en la ciudad trasladaron el escenario a las calles. Ruttmann durante el rodaje de Berlín, sinfonía de una gran ciudad (1927) prescindió del estudio y actores profesionales. Meisel compuso la música adaptada a los fotogramas. Pero, el director alemán también experimentó con los sonidos y los ruidos en sus filmes ópticos y en su programa de radio. Ello permite constatar la interrelación entre el cine experimental, la necesidad de pintar sonidos y la renovación de los instrumentos. En suma, presentamos una breve reflexión sobre el sonido y su repercusión en el cine mudo.
El arquitecto y académico Cristóbal Sales Gutiérrez (1763-1833) al servicio de la ciudad de Valencia y sucesores en el cargo hasta 1860
Authors: Pingarrón-Esaín Seco Fernando
Published: April 2023

El presente trabajo analiza fundamentalmente la intensa trayectoria del arquitecto y académico Cristóbal Sales Gutiérrez en la ciudad de Valencia durante su larga etapa como primer arquitecto de su Consistorio. Precisamente el edificio sede de esta institución es objeto de especial estudio bajo su dirección, así como de los casi treinta años posteriores a la muerte de Sales hasta resolverse la demolición de su señera fábrica. El estudio se completa con aportaciones biográficas, tales como su enlace matrimonial y su testamento.
L'església parroquial de Sant Bartomeu de Valldemossa (Mallorca). De la fàbrica medieval a la imatge contemporània
Authors: De Mirabò Concepció Bauçà
Published: April 2023

El trabajo constituye un estudio diacrónico sobre la Iglesia parroquial de San Bartolomé de Valldemossa e incide en la evolución de su configuración arquitectónica exterior, desde la primera fachada documentada hasta la actualidad. Utiliza fuentes documentales inéditas para reconstruir las distintas reformas que sufrió dicho frontis desde la tradición gótica mallorquina, pasando por la influencia del Clasicismo decimonónico, hasta el Regionalismo del siglo XX. Hoy su imagen sigue contribuyendo a la creación de un paisaje único en la Serra de Tramuntana.
Joan Cardona, pintor de la Ciudad de Valencia (1523-1556) y su versátil taller
Authors: Arciniega García Luis
Published: April 2023

Joan Cardona es un pintor que, como muchos otros de su época, refleja la versatilidad que era necesaria, y, como pocos, el éxito profesional, aunque no se acompañe de reconocimiento historiográfico. Este se justifica en la escasez de obra identificable y en el prejuicio que ha supuesto reducirlo a una vertiente meramente decorativa, sustentada en el hecho de que figure como cortinero en la solicitud de colegio de pintores de Valencia de 1520; una propuesta en la que tuvo especial protagonismo. Sin embargo, el análisis de su trayectoria a través de distintos fondos documentales nos muestra amplia capacidad figurativa en distintos soportes. Durante el segundo cuarto del siglo XVI fue el pintor de mayor éxito socio-profesional a tenor de su contribución a los impuestos de la tacha real y de los cargos institucionales que ocupó. El de pintor de la Ciudad lo ostentó desde 1523 hasta su muerte en 1556, suponiendo la inflexión entre los pintores cajeros medievales y los retablistas de la segunda mitad del XVI. La vinculación con las principales instituciones y una pintura que va más allá de lo hagiográfico lo convierten en sólido candidato a algunas obras que con impronta de los Hernandos siguen bajo nombres de laboratorio
Un viaje de ida y vuelta al otro mundo. El Cabaret del Diavolo de Gino Gori y Fortunato Depero en Roma (1922-1925)
Authors: Mancebo Roca Juan Agustín
Published: April 2023

Los cabarets romanos vinculados al futurismo fueron espacios de encuentro en los que se aplicó el programa del manifiesto Ricostruzione futurista dell´universo. Tras las experiencias de Bragaglia y Marchi en el Circolo delle Cronache d´Atualità y la ambientación de Giacomo Balla en el Bal Tic Tac, el empresario y poeta Gino Gori encargó la decoración del Cabaret del Diavolo a Fortunato Depero. Basado en la Commedia dantesca, Depero realizaría un diseño integral de tres espacios que configuraban una alegórica lectura invertida del viaje al ultramundo del poeta florentino. Su originalidad y cuidada publicidad convirtieron al cabaret en uno de los espacios representativos de la noche romana que, pese a su éxito, terminó cerrando en 1925 perdiéndose la mayoría de los elementos de decoración y mobiliario. Este artículo reconstruye el proyecto del Cabaret del Diavolo a partir de las piezas de ambientación que lo sobrevivieron y a sus testimonios gráficos: fotografías, bocetos, notas de prensa y material de archivo reivindicando su importancia en la carrera de Fortunato Depero y en los programas futuristas sobre el teatro, la decoración y la escenografía.
Presentació del monogràfic «El complement directe preposicional: una visió panromànica»
Authors: Pineda Anna
Published: April 2023

Presentació del monogràfic «El complement directe preposicional: una visió panromànica», coordinat per Anna Pineda.
Differential Object Marking in Apulia: A descriptive overview
Authors: Andriani Luigi
Published: April 2023

This article describes the distribution of Differential Object Marking in Puglia/Apulia (Southeast Italy), where both Upper-Southern (Pugliese/Apulian) and Extreme-Southern (Salentino) Italo-Romance varieties are spoken. This first survey on DOM in Apulia presents evidence from both existing literature and an online questionnaire with native speakers. The latter tests a selection of referents sitting at different levels of the Definiteness Hierarchy, from personal pro- nouns to indefinite nouns, in order to ascertain whether specificity can(not) be considered the ultimate DOM-trigger in these varieties. In this respect, only animate direct object conveying new information are tested, whereas highly specific clitic-doubled topical structures are left for future research. In this first attempt at mapping the fine-grained microvariation of DOM throughout the Apulian peninsula, it appears that its distribution is very limited in Salentino, being restricted to personal pronouns, while Apulian varieties display more extended DOM systems; these may be sensitive to minimally different (lexico-)semantic factors for triggering DOM at the lower levels of the Definiteness Hierarchy.
ESTUDIO DE SALARIOS NOMINALES A TRAVÉS DE LA PRIMA DE HABILIDAD EN EL COLECTIVO DE TRABAJADORES DE LA SOTSOBRERIA DE MURS I VALLS DE VALENCIA (1380-1420).
Authors: Quiles Ruiz Jordi
Published: April 2023

El presente artículo expone la evolución de los salarios nominales pagados por la Junta de Murs i Valls de la ciudad de Valencia desde el año 1380 a 1420 desde el punto de vista de la prima de habilidad, concepto utilizado para cuantificar el diferencial de los salarios de dos colectivos. En este caso, el factor utilizado para segregar los grupos a comparar es el grado de especialización profesional, comparando tanto el nivel de máxima cualificación –supercualificados- contra el resto de colectivos profesionales como las categorías centrales –cualificados y no cualificados- entre ellas.
El treball de les dides als hospitals medievals valencians del segle XV
Authors: Martí Serrano Andrea
Published: April 2023

L’article tracta el treball de les dides als hospitals valencians d’En Clapers i de la Reina al segle XV. És centrarem en abordar les cinc qüestions següents: la gran quantitat de dides i els motius d’aquest nombre, les tasques que aquestes dones portaven a terme, la duració del seu treball, el seu salari i els orígens socials de les alletadores.
This article aims at discussing the work of the nursemaids in Valencia’s hospitals d’En Clapers and de la Reina in the 15th century. We will focus on five of the following sub-themes: the huge number of nursemaids and the cause of it, the tasks of these women, the length of their job, their salary, the location and the social origins of the nursemaids.
La tecnología de la escultura ibérica en piedra: el León de Bocairent
Authors: Cebrián Alonso Enriqueta , Gisbert Aguilar Josep
Published: April 2023

La tecnología de extracción, transporte y talla de la piedra en la antigüedad es todavía una de las más inexploradas líneas de investigación. Recientes estudios han facilitado la unificación de los métodos y la fijación de unas directrices de trabajo interdisciplinares. Su aplicación a la escultura ibérica se orienta hacia la caracterización de los materiales, la identificación de las canteras y las huellas de los instrumentos, siguiendo un camino de larga tradición en la escultura griega y romana. La sistematización de los datos permitirá en un futuro reconocer talleres, centros de fabricación de útiles y vías de transporte de los materiales, además de establecer una relación con la tecnología de otras producciones escultóricas mediterráneas.
Aproximación iconográfica a la representación de Malinche como intermediaria entre Cortés y Moctezuma II
Authors: Sola Rubio Nathaniel
Published: April 2023

En el siguiente artículo se analizará, a través de tres imágenes pertenecientes a los documentos pictográficos y códices coloniales más significativos del siglo XVI, la figura de Malinche, mediante el tema de su imagen entre Cortés y el tlatoani Moctezuma II. Por medio de este estudio comparativo, se realizará una aproximación a los significados de dichas representaciones, teniendo en cuenta, principalmente, la efigie primigenia de Malinche como intercesora del encuentro entre el mundo indígena y el europeo.
LA CONSTRUCCIÓN DE LA IMAGEN FÍLMICA DE ENRIQUE VIII. Los referentes histórico-artísticos de The Private Life of Henry VIII (1933)
Authors: Ávila Valverde Andrés
Published: April 2023

Los Tudor son una de las dinastías más icónicas de la historia, despertando el interés no solo de la pintura sino también del cine. Esto es debido tanto al dramatismo de su historia como a su vinculación con el discurso histórico-nacional del Reino Unido. De este modo, la gran cantidad de contenido audiovisual dedicado a los Tudor anima a descubrir cuáles han sido las características compartidas y cuál es la base sobre la que se ha creado dicho contenido. El presente estudio se centra en la construcción visual de la imagen fílmica del rey Enrique VIII (1491-1547) a partir del análisis de la película británica The Private Life of Henry VIII (1933) del director húngaro Alexander Korda (1893-1956). Esta investigación ha sido posible gracias a la dependencia entre el audiovisual contemporáneo y la imagen del monarca, creada en el siglo XVI por Hans Holbein el Joven (ca. 1497-1543), así como de la interpretación que tanto la historiografía como la literatura han hecho de la misma. Con todo ello, la obra de Korda, inserta en la continuidad y variación de la imagen del monarca, supone una interpretación propia tanto de los sucesos pretéritos del pasado como de los vestigios visuales y arquitectónicos que de este nos han llegado.
Sindicalisme socialista a la Vall d'Albaida durant la Segona República i la Guerra Civil: un espai de convivència entre treballadors i treballadores?
Authors: Benavent Montoro Isabel
Published: April 2023

Resum: Durant la Segona República s’aprovaren diverses lleis per regular els drets cívics i polítics de les dones, però dintre del socialisme continuaren existint posicionaments i concepcions diferents sobre el treball femení i el paper que havien de tenir les dones en les seues agrupacions i en la societat. El present article analitza la presència de les dones al sindicalisme socialista a la comarca de la Vall d’Albaida durant la Segona República i la Guerra Civil, atenent especialment a les relacions entre treballadors i treballadores sindicats en un context d’organització de societats socialistes.  
Abstract: During the Second Republic several laws were passed to regulate the civic and political rights of women, but within socialism there were still different positions and conceptions about women’s work and the role that women should play in their groups and in society. This paper analyses women’s presence in socialist trade unionism in the region of Vall d'Albaida during the Second Republic and the Civil War, especially taking into account the relations between workers in a context of organizing socialist societies.
INFLUENCIA PATERNA. MOVILIDAD SOCIAL Y GEOGRÁFICA EN LA FORMACIÓN DE LOS NÚCLEOS FAMILIARES A PARTIR DE CONTRATOS MATRIMONIALES Y DONATIONES INTER VIVOS (VALENCIA, SIGLO XV)
Authors: Tortosa Quirós Jaime
Published: April 2023

En este artículo se ha analizado un considerable abanico de contratos matrimoniales y donationes inter vivos de la Valencia del siglo XV para tratar de observar la influencia paterna en la concertación nupcial. Igualmente, se ha estudiado la flexibilidad de la institución matrimonial, para comprobar hasta qué punto facilitaba o entorpecía la unión entre individuos de distinta zona o estatus, con el consiguiente desplazamiento social y geográfico que ello supondría. En definitiva, se ha intentado conocer mejor los mecanismos de transmisión patrimonial intergeneracional y las posibilidades que ofrecía el matrimonio de cara a la creación de una nueva familia.
Immunopeptidomics reveals determinants of Mycobacterium tuberculosis antigen presentation on MHC class I
Authors: Leddy Owen , White Forest M , Bryson Bryan D
Published: April 2023

CD8+ T cell recognition of Mycobacterium tuberculosis (Mtb)-specific peptides presented on major histocompatibility complex class I (MHC-I) contributes to immunity to tuberculosis (TB), but the principles that govern presentation of Mtb antigens on MHC-I are incompletely understood. In this study, mass spectrometry (MS) analysis of the MHC-I repertoire of Mtb-infected primary human macrophages reveals that substrates of Mtb’s type VII secretion systems (T7SS) are overrepresented among Mtb-derived peptides presented on MHC-I. Quantitative, targeted MS shows that ESX-1 activity is required for presentation of Mtb peptides derived from both ESX-1 substrates and ESX-5 substrates on MHC-I, consistent with a model in which proteins secreted by multiple T7SSs access a cytosolic antigen processing pathway via ESX-1-mediated phagosome permeabilization. Chemical inhibition of proteasome activity, lysosomal acidification, or cysteine cathepsin activity did not block presentation of Mtb antigens on MHC-I, suggesting involvement of other proteolytic pathways or redundancy among multiple pathways. Our study identifies Mtb antigens presented on MHC-I that could serve as targets for TB vaccines, and reveals how the activity of multiple T7SSs interacts to contribute to presentation of Mtb antigens on MHC-I.
Antisense, but not sense, repeat expanded RNAs activate PKR/eIF2α-dependent ISR in C9ORF72 FTD/ALS
Authors: Parameswaran Janani , Zhang Nancy , Braems Elke , Tilahun Kedamawit , Pant Devesh C , Yin Keena , Asress Seneshaw , Heeren Kara , Banerjee Anwesha , Davis Emma , Schwartz Samantha L , Conn Graeme L , Bassell Gary J , Van Den Bosch Ludo , Jiang Jie
Published: April 2023

GGGGCC (G4C2) hexanucleotide repeat expansion in the C9ORF72 gene is the most common genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). The repeat is bidirectionally transcribed and confers gain of toxicity. However, the underlying toxic species is debated, and it is not clear whether antisense CCCCGG (C4G2) repeat expanded RNAs contribute to disease pathogenesis. Our study shows that C9ORF72 antisense C4G2 repeat expanded RNAs trigger the activation of the PKR/eIF2α-dependent integrated stress response independent of dipeptide repeat proteins that are produced through repeat-associated non-AUG-initiated translation, leading to global translation inhibition and stress granule formation. Reducing PKR levels with either siRNA or morpholinos mitigates integrated stress response and toxicity caused by the antisense C4G2 RNAs in cell lines, primary neurons, and zebrafish. Increased phosphorylation of PKR/eIF2α is also observed in the frontal cortex of C9ORF72 FTD/ALS patients. Finally, only antisense C4G2, but not sense G4C2, repeat expanded RNAs robustly activate the PKR/eIF2α pathway and induce aberrant stress granule formation. These results provide a mechanism by which antisense C4G2 repeat expanded RNAs elicit neuronal toxicity in FTD/ALS caused by C9ORF72 repeat expansions.
Prognostic value of sirtuin family members and experimental verification identify SIRT5 as diagnostic biomarkers in clear cell renal cell carcinoma
Authors: Peng Lu-Shan , Duan Sai-Li , Li Run-Qi , Bai Zi-Yuan , Ou Chun-Lin , Wang Jun-Pu
Published: April 2023

Background

The sirtuins (SIRTs) family is a nicotinamide adenine dinucleotide (NAD+) family of dependent deacetylases, which includes SIRT1-7. This family is related to the development and progression of various tumors. However, a comprehensive analysis of the role of SIRTs in clear cell renal cell carcinoma (ccRCC) is still lacking, and there are few reports on the inhibitory role of SIRT5 in ccRCC.

Methods

We used immunohistochemical analysis, and several bioinformatic databases to perform an integrated analysis of the expression and prognostic value of SIRT5 and other SIRT family members in ccRCC along with the associated immune cell infiltration. These databases include TIMER, THPA, cell culture, UALCAN, cBioPortal, WebGestalt, Metascape, DiseaseMeth, STRING database, and Cytoscape.

Results

The protein expression of SIRT1, 2, 3, 6, and 7 were upregulated in ccRCC for the Human Protein Atlas database, whereas the expression of SIRT4 and SIRT5 was decreased. The expression based on tumor stage, and grade followed a similar trend. Kaplan–Meier analysis showed that high SIRT4 and SIRT5 expression was positively related to better overall survival (OS), whereas SIRT6 and SIRT7 expression was positively related to worse OS. Further, high SIRT3 expression was related to worse relapse-free survival (RFS), whereas high SIRT5 expression was related to better RFS. To explore the mechanism underlying the function of SIRTs in ccRCC, we also used several databases to perform the functional enrichment analysis and explore the relationship between infiltrating immune cells and seven SIRT family members in ccRCC. The results showed that several SIRT family members, and particularly SIRT5, are correlated with the infiltration of some important immune cells. The protein expression of SIRT5 was significantly lower in tumor tissue compared to normal tissue and was negatively related to the age of the patient ccRCC individual tumor stages, and grades. In human ccRCC samples, strong IHC staining expression of SIRT5 was displayed in adjacent normal tissue than in tumor tissues.

Conclusion

SIRT5 may be a prognostic marker and a novel strategy for the treatment of ccRCC.
Corporate social responsibility: a model for companies in the solidarity sector
Authors: Soto José Andrés Bayona , Claro Genny Torcoroma Navarro , Pineda Jairiny Alejandra Jaime
Published: April 2023

Resumen

Propósito: El propósito de este estudio es analizar el grado de implementación de la Responsabilidad Social Empresarial en las organizaciones solidarias y desarrollar una propuesta para mejorar su gestión.

Diseño/metodología/enfoque: la investigación es descriptiva, el diseño es de fuente mixta, por lo que se analizó el evento a través de la combinación de fuentes vivas y la revisión de documentos de organizaciones solidarias. Según la temporalidad el estudio es transeccional-contemporáneo; de acuerdo al enfoque de la investigación es univariado, se utilizaron las técnicas revisión documental, observación directa e indirecta y se aplicó encuestas y entrevistas a trabajadores y líderes de las empresas.

Hallazgos: En cuanto a las variables de Responsabilidad Social Empresarial se puede observar que las organizaciones solidarias presentan debilidades en las suyas, las empresas han realizado algunos acercamientos, pero desconocen todas las actividades que se deben realizar para lograr la efectividad del proceso. Es posible que requieran mayor conocimiento y orientación, por lo que los investigadores proponen un modelo como herramienta orientadora en la integración de la responsabilidad social empresarial en los diferentes procesos de las organizaciones objeto de estudio.

Originalidad/valor: Los hallazgos del estudio contribuyen con una mejor orientación para la comprensión de la responsabilidad social empresarial y su implementación efectiva en las organizaciones del sector solidario.
Mid Upper Arm Circumference as the Best Surrogate Marker for Identification of Low Birth Weight in Newborns within the First 24 Hours of Life- A Cross-sectional Study
Authors: Sawale Jayashri Chandrakant , Dhande Leena Ajay , Nagrale Pooja Bhimashankar
Published: April 2023

Introduction: Birth weight is a very important determinant factor regarding perinatal morbidity and mortality. However, in developing countries like India weighing facility may not be available in rural areas where an alternative anthropometric parameter like Mid Upper Arm Circumference (MUAC) may be considered alternative to birth weight. Aim: To determine the accuracy of MUAC by comparing it with different anthropometric parameters for identification of LBW in neonates within the first 24 hours of life. Materials and Methods: The present study was a hospital based cross-sectional study conducted in labour ward, Postnatal Care (PNC) wards and Neonatal Intensive Care Unit (NICU) of Indira Gandhi Medical College, Nagpur. Total 640 babies were enrolled over a period of 2 years from September 2018 to September 2020. Anthropometric parameters like weight, length, head circumference, Chest Circumference (CC), MUAC, ponderal index were taken by a researcher using standard techniques within first 24 hours of life and correlated with birth weight by using Pearson’s correlation coefficient. The comparison of the quantitative and qualitative variables was analysed using independent t-test and chi-square test, respectively. Receiver Operating Characteristic (ROC) curve was used to find out cut- off point of anthropometric parameters for predicting birth weight (<2000 gm, <1500 gm, <1000 gm). DeLong test was used for comparison of area under curve between different anthropometric parameters for predicting birth weight (<2000 gm, <1500 gm, <1000 gm). Univariate linear regression was used to assess the effect of anthropometric parameters on birth weight. The data entry was done in the Microsoft EXCEL spreadsheet and final analysis was done with the use of Statistical Package for Social Sciences (SPSS) software version 21.0. Results: Among 640 newborns, 334 (59.19%) were females and 306 (47.81%) were males. The mean birth weight was 1903.93 grams and MUAC of 8.3cm. All the chosen parameters showed significant correlation with birth weight (p<0.001). However, MUAC showed strongest correlation (r=0.890) with birth weight and easy to measure. Cut-offs of MUAC ≤8.45 cm, ≤7.5 cm, ≤6.8 cm predict birth weight of <2000gm, <1500gm, <1000gm with sensitivity of 91.22%, 92.81%, 100% and specificity of 88.95%, 89.12%, 89.35%, respectively. Conclusion: MUAC is the most simple and best surrogate measure that can be used in domiciliary outreach when it is impossible to record weight of baby at birth.
Evaluation of Proximate, Minerals, Vitamins and Antinutrient Composition of Combretum platypterum (Welw.) Hutch. & Dalziel. (Combretaceae) Leaves
Authors: Onyegbulam Chukwuma Michael , Chidinma Mba Theodora , Estella Odoh Uchenna , Ezugwu Christopher Obodoechi , Obisike Chukwube Vincent , Ugorji Chima
Published: April 2023

Background: Combretum platypterum (Welw.) Hutch. & Dalziel. (Combretaceae) leaves are used in treatment of jaundice and hepatitis in South-Eastern Nigeria. Evaluations of the nutritional composition of medicinal plants can enhance their profile as sources of food and medicines. This research aims to determine the proximate composition, minerals, vitamins, and anti-nutrients contents of Combretum platypterum (Welw.) Hutch. & Dalziel (Combretaceae) leaves.

Methods: Proximate, minerals, and vitamins analysis are done according to the standard methods described by AOAC. Spectrophotometric methods and AAS were used to determined minerals. For the ANFs, oxalate concentration was determined using the permanganate titration method, phytate determination was based on the analysis of phosphorus in a ferric phytate complex, assuming a constant 4Fe: 6P molecular ratio in the complex. Tannins, trypsin inhibitors, and hemagglutinins were evaluated using other standard methods. 

Results: Mineral content: Cal 1.14 mg/100g, Mg1.58 mg/100g, Mn 0.268 mg/100g, Cu 0.176 mg/100g, Zn 5.9 mg/100g, Se 0.957 mg/100g, Fe 3.596 mg/100g, K 1.537 mg/100g, Na 0.6 mg/100g, phosphorus 0.58mg/100g. Proximate analysis: protein 3.327 %, moisture 4.45 %, ash 2.65%, fibre 4.3%, fat 2.20 %, carbohydrates 83.07 %. Anti-nutrients content: oxalate: 0.577mg/100g, phytate 0.567mg/100g, hemagglutinin 0.428HU/mg, tannins 123.53 mg/100g), trypsin inhibitor 0.647±.003HIU/mg. Vitamin analysis: Vitamin C 0.328 mg/100g, vitamin D 0.227 mg/100g, vitamin E 0.59 mg/100g, vitamin K 0.137 mg/100g, and vitamin A (retinol) 4.507 µg/g  

Conclusion: Combretum platypterum (Welw.) Hutch. & Dalziel (Combretaceae) leaves are rich in proximate elements, vitamins and essential minerals and low levels of antinutrients.
Study on the Incidence of Sucking Pests and Pink Bollworm in Cotton
Authors: Rajasekhar N. , Subbaiah P. Venkata , Prasad P. N. Siva , Narasimha M. Raja , Reddy I. Venkata
Published: April 2023

Sucking pests and pink bollworm are serious pest of cotton one after the other in India by causing serious yield losess. The present investigation was carried out in three major cotton growing mandals of NTR district to understand the level of pest incidence in Bt cotton during Kharif, 2022-23 on regular interval. Among the sucking pests only thrips population recorded 32.26 no/3 leaves and crossed the ETL at 45 DAS. Remaining sucking pests such as Leafhopper, whitefly and aphid did not crossed ETL during crop growth period and highest incidence of 5.92, 4.04 and 27.14 no/3 leaves was recorded respectively at 45, 60 and 120 DAS. Whereas pink bollworm recorded 23.10% rosette flowers, 44.04% boll damage in Bheemavaram village of Vastavai mandal and 40.83% locule damage in Konakanchi village of Penuganchiprolu mandal.