bluuebunny/crossref_metadata_2025 huggingface dataset:
時間，被忽略的愛情要素:平衡時間觀、趨避承諾對愛情關係品質的影響
Authors: 游心慈 游心慈 , 陳慧娟 陳慧娟
Published: February 2024

本研究旨在探討平衡時間觀（Balanced Time Perspective， BTP）、趨避承諾與愛情關係品質之相關性，並以趨避承諾為中介變項，了解BTP對愛情關係品質之影響機制。本研究採便利取樣方式招募臺灣地區742位18-34歲之研究參與者，填寫研究者自編之測驗工具，包括時間觀量表、趨避承諾量表與愛情關係品質量表，有效樣本共計722份，其中男性佔30.61%、女性佔69.11%。本研究的BTP是採用Stolarski等人（2011）開發之「平衡時間觀離差值法」（Deviation from Balanced Time Perspective， DBTP），即計算每位參與者在各時間觀向度上觀察到分數和理想分數之間的總差距，做為估計BTP的基礎。接著以SPSS23、Lisrel 8.52統計軟體與拔靴法（Bootstrap）執行t考驗、變異數分析、皮爾森積差相關分析及中介效果分析考驗研究假設。研究結果顯示：（1）BTP及趨避承諾均可顯著預測愛情關係品質（含整體關係品質及五大子指標），且BTP可顯著預測趨避承諾;（2）趨向承諾對BTP與整體愛情關係品質及滿意度指標具有部分中介效果;迴避承諾在BTP與愛情關係品質中的兩大指標（反對與誤解、矛盾與衝突）亦扮演中介角色，代表BTP可顯著預測愛情關係品質，其中有部分效果是透過趨避承諾而產生的間接作用。文末對本研究結果進行討論，並提出後續研究與實務工作之建議。

 

This study aimed to understand the relationship between balanced time perspective, approach-avoidance commitment, and love relationship quality among 722 unmarried Taiwanese aged 18-34 years. We edited the Time Perspective Inventory, Approach-Avoidance Commitment Test, and Love Relationship Quality Form to test their approach-avoidance commitment and love relationship quality. Subsequently, we calculated their deviation from the balanced time perspective score to represent their balanced time perspective(DBTP). Data obtained in this study were tested using the t-test, analysis of variance, Pearson correlation analysis, and mediating effect analysis with statistical analysis systems, including SPSS 23 and Lisrel 8.52. The main findings revealed that balanced time perspective could significantly predict love relationship quality, including general quality and five indicators, and that balanced time perspective could significantly predict approach-avoidance commitment. Approach commitment could be a mediator between balanced time perspective and general relationship quality and relationship satisfaction; avoidance commitment could be a mediator between balanced time perspective and two indicators of relationship quality: objections and misunderstandings and conflict and ambivalence. To sum up, balanced time perspective could predict love relationship quality and, partially, through avoidance commitment. Finally, the limitations and contributions of the research were discussed, as well as suggestions for future applications in counseling and research directions.

 
Investigating Wasta Challenges in Audit Practices in the Middle East: A Critical Review
Authors: Shaikha Khalfan Shaikha Khalfan
Published: February 2024

Wasta is widespread across the Middle East, and practiced as a common and acceptable culture in most organizations. Wasta is based on misuse of power for personal gain, which has huge negative impacts on the business. The reviewed literature highlights the complex reality of auditing in the region, the complexity increased by existence of wasta and corruption. Auditors in the region face difficult ethical challenges as they attempt to balance their professional responsibilities with the pressures of wasta-driven environments. This paper seeks to further investigate these challenges and provide insights that can guide auditors, regulators, and organizations in addressing them.
General Ledger Computer Auditing Practice: Implementing a Smart Auditing Approach
Authors: Sherry Huang Sherry Huang
Published: February 2024

This paper showcases how JCAATs, an AI audit Software, can facilitate a smart auditing approach using General Ledger data compliant with the Audit Data Standards introduced by the American Institute of Certified Public Accountants (AICPA). We begin with an overview of the Audit Data Standards by the AICPA, followed by an exploration of the necessity for a smart auditing approach. Utilizing JCAATs, we demonstrate a smart auditing process for General Ledger accuracy testing to verify the correctness of amounts in the general ledger accounts, ensuring alignment with description and source documents.
Ecology and Gender in Sir Launfal
Authors: Frenze Maj-Britt
Published: February 2024

This article examines the relationship between landscape and gender in Marie de France’s Lanval and two of its adaptations: the fourteenth-century English romances Sir Launfal and Sir Landevale. Engaging with the ecofeminist principles of Val Plumwood, it contends that the character of the “fairy mistress” and the nature of her otherworldly realm undergo significant changes by adaptation into Middle English, specifically, changes that diminish female agency. As she is adapted into English texts, especially Sir Launfal, the Lanval fairy is made subject to patriarchal hierarchies, and the otherworld is similarly presented as an object of patrimony.
Experience from a light trap Lepidoptera survey in a populated settlement: effects of meteorological factors and changes in lunar phases
Authors:   Ferenc Rákóczi II Transcarpathian Hungarian College of Higher Education (Beregovo, Ukraine), Vass Gábor ,   University of Sopron (Sopron, Hungary), Hadnagy István ,   Ferenc Rákóczi II Transcarpathian Hungarian College of Higher Education (Beregovo, Ukraine), Kohut Erzsébet ,   Ferenc Rákóczi II Transcarpathian Hungarian College of Higher Education (Beregovo, Ukraine), Kolozsvári István ,   Ferenc Rákóczi II Transcarpathian Hungarian College of Higher Education (Beregovo, Ukraine)
Published: February 2024

In the framework of the research, light trap Lepidoptera collections were carried out in the territory of a settlement (Velyki Berehy, Zakarpatska Oblast, Ukraine), which is bordered by nature reserves, forests, and agricultural areas, as well as by the remains of a large marsh (Szernye bog) that had been drained in the past. A Jermy light trap with a household LED bulb was used to capture the moths and butterflies. In addition to assessing the Lepidoptera fauna of the area, the study aimed to find out which species of Lepidoptera are attracted to energy-saving light bulbs commonly used in households in a settlement located in a habitat-diverse environment. In addition to the artificial light pollution conditions and other anthropogenic influences of the settlement, the direction and magnitude of the effects of temperature, relative humidity, cloud cover, wind speed, and moon phase parameters at the time of collection on the flight trends of nocturnal Lepidoptera species were also investigated. A total of 97 days of collecting between May 2018 and May 2019 resulted in the collection of 122 Lepidoptera species from 16 families. In terms of their ecological requirements, species were found in closed and open forest, forest edge, scrub, meadow, actively cultivated and abandoned agricultural areas, as well as in dry and wet areas. Several species considered being agricultural, forestry, or horticultural pests were identified, but not in abundance. Among the environmental variables, temperature variation showed a strong significant positive correlation with daily species numbers and abundance, while relative humidity, wind speed, cloud coverage and moon phases showed varying degrees of negative correlation, but were generally weak. The effects of the interactions of natural and man-made environmental influences on living organisms are difficult to assess objectively, but their research is of paramount importance for the long-term effective conservation of habitats of particular conservation value and for the preservation of their biodiversity.
Dragonflies of Moldova: an updated checklist of the Odonatofauna
Authors:   Worldwide Dragonfly Association (Odesa, Ukraine), Dyatlova Olena
Published: February 2024

The present research compiles all known records of dragonflies in Moldova, including Transnistria (from the beginning of the 20th century until present), based on all known literature and other sources, and also the personal observations of the author in 2005, 2009, and 2011. Brief history of Moldovan odonatology is given with the gap of more than 50 years of odonatological studies in Moldova in the middle of the last century. The analysis shows that the checklist of Odonata in Moldova comprises 37 species. The presence of several species in Moldova needs confirmation. The probable absence of Nehalennia speciosa in the territory of Moldova is discussed in the article based on the opinion of other authors and the lack of favourable habitats in the area. The map presented illustrates the areas in Moldova with the lack of data on the presence of dragonflies. This elucidated the understudied regions. Unfortunately, some records from the literature sources are given without any coordinates, so they could not be mapped. This analysis will help in planning further research into dragonflies of Moldova. Moldova still remains poorly studied from an odonatological point of view. Further investigations will undoubtedly fill in the ‘white spots’ on the distribution of species in the territory of Moldova and will help in the development of modern recommendations of habitat protection, underline urgent conservation measures in the country and highlight priority species. We expect that 10 to 20 species of dragonflies remain to be discovered in Moldova. Also, field research in different phenological periods will presumably help to add some new species. The data about dragonflies of Moldova were amended after three field trips of the author in 2005 (the area near Saharna) and in 2009 and 2011 (the route covered the territory of Moldova from south to north). Based on the author’s field research, three species of dragonflies are listed for the first time for the territory of Moldova: Lestes macrostigma, Coenagrion ornatum, and Orthetrum brunneum. For one species, Coenagrion scitulum, the exact locations are given for the first time by the author. The presence of the species of European concern in Moldova include Lestes macrostigma and Coenagrion ornatum, and Gomhus flavipes might be considered as well by odonatologists from the neighbouring countries.
Analysis of the activity of bird communities in city parks: a case study of Dnipro City, Ukraine
Authors:   Dnipro National University (Dnipro, Ukraine), Komlyk Yuliia , Ponomarenko Oleksandr ,   Dnipro National University (Dnipro, Ukraine)
Published: February 2024

The article presents the results of the analysis of bird communities’ activity in the parks of the right-bank part of Dnipro City during the breeding season of 2022–2023. It was established that 51 bird species consistently exhibit activity in the city parks. Among them, more than half (68.6 %) belong to the order Passeriformes. The analysis of the obtained data indicates that common species such as the house sparrow, chiffchaff, great tit, and white wagtail demonstrate the highest activity in all investigated parks and squares. The widespread presence of these species suggests their flexible use of spatial resources in urban parks, indicating their adaptability to anthropogenic environments. Applying the Rodgers–Shannon overlap index allowed determining the similarity degree of bird community parameters. The results indicate significant similarity among communities in several parks in the right-bank part of Dnipro, associated with their small area, proximity to residential buildings, and common tree crown pruning stages. The correlation between bird diversity and the size and characteristics of park territories was investigated. The correlation matrix revealed a clear positive relationship between park area and the number of bird species exhibiting activity. This is attributed to the greater environmental heterogeneity and the presence of resources for survival, which, in turn, enables representatives of different ecological complexes to realise their ecological and spatial niches. This is explained by the greater heterogeneity and the availability of resources for survival, facilitating the realisation of various ecological and spatial niches for different species. Some parks in the right-bank part of the city exemplify a clear connection between park area and bird species diversity. It was found that with an increase in park area by an average of 2.9556 hectares, the number of bird species increases by one. Additionally, a correlation was observed between the number of tree species in the territory and the bird communities’ biodiversity of the park or square, emphasising the importance of the plant cover for preserving and attracting bird diversity.
Zoologist Sergiy Paramonov and his ‘Chemogenesis—A New Theory of Evolution’ (to the 130th anniversary of his birth)
Authors:   Ukrainian Theriological Society, NAS of Ukraine (Kyiv, Ukraine), Mikhalenok Dmytro
Published: February 2024

The paper present little-known aspects of the scientific activity of the famous expatriate scientist, world-renowned Ukrainian and Australian zoologist, theoretical biologist, and dipteriologist Sergiy Paramonov (1894–1967). The main purpose of this work is to give a detailed presentation to the scientific community on the important but little-known work of the scientist titled ‘Chemogenesis—A New Theory of Evolution’ (theory of chemogenesis). The role of the Kara Dag scientific station (Crimea, Ukraine) in the formation of the so-called points of scientific growth is shown. The scientist had visited the station several times to carry out dipteriologial research; in 1925, he met the famous Russian scientist S. L. Ivanov whose reconsidered research was used in creating the theory of chemogenesis. Paramonov’s theoretical works written in Ukraine in 1934–1943 and devoted to issues of systematics and its novel chemical methods and of species and speciation are briefly considered. Selected postulates of the theory of chemogenesis are described and analysed in short. The scientist drew special attention to the criticism of Darwin’s theory of natural selection and considered it a brilliant achievement of human thought of the 19th century. Noteworthy is that the theory of chemogenesis does not rely on the recognised scientific significance of related areas of knowledge such as geochemistry and biochemistry, but pulls away from them to prove its own correctness. Paramonov had been seeking the truth but did not claim it; he merely tried to show another way to understand the driving forces of evolution, to show that biologists are ‘barking up the wrong tree.’ A logical mistake keeps existing in biology, when the result (morphogenesis) is considered as the cause, and the cause (chemogenesis) as the results. Eliminating natural selection the scientist understood that he had opened a way to recognise various ‘mysterious’ forces. Although Paramonov did not present a respective philosophical basis for his theory, it is still worth mentioning that the solution for the existing antinomy between the mechanistic theory of natural selection and the theory of chemogenesis with certain elements of teleology lies in the combination of mechanistic and teleological explanation of nature. It is important to take the first steps into the unknown, to understand the incomprehensible, or even to admit ignorance than to engage in the simplification of the problem.
Yuri Dubrova (1955–2023)—a biologist from Ukraine heard by the world: notes on his biography
Authors:   National University of Life and Environmental Sciences of Ukraine (Kyiv, Ukraine), Prydatko-Dolin Vasyl
Published: February 2024

The future famous geneticist Prof. Yuri Dubrova (1955–2023) was born in Kyiv (Ukraine), where he received excellent secondary and higher education and was awarded with a gold medal upon graduating from school. Eventually, he became one of the best graduates of the Department of Vertebrate Zoology at the Faculty of Biology of Taras Shevchenko National University of Kyiv. His interests included theoretical biology, evolutionary theory, genetics, biometrics, and bionics (for some time he studied the lateral lineage of cyprinid fishes). In his last years at the university, he focused on the study of spontaneous mutations. At the Vavilov Institute of General Genetics in Moscow, Y. Dubrova continued his post-graduate studies and successfully defended his PhD thesis. After the collapse of the USSR, he moved to the UK in search of better scientific and technical opportunities, where he became a professor at the University of Leicester. The scientist lived and worked in Leicester until the end of his life. He devoted himself fully to science, especially to radiation, medical and population genetics, and to teaching, and tried to participate in the study of highly complex medical and genetic issues related, in particular, to the consequences of man-made disasters—Chornobyl (Ukraine, Belarus), Semipalatinsk (Kazakhstan)—and other cases of large-scale radiation effects on life. Dr. Dubrova is the author and co-author of more than 150 scientific articles published in leading journals, including the American Journal of Human Genetics, International Journal of Radiation Biology, Radiation Research, Molecular Biology and Evolution, International Journal of Cancer, British Journal of Cancer, Science, and Nature. He co-operated with many of the world’s leading geneticists and gave lectures in Ukraine, Russia, the USA, Canada, Japan, etc. The article uses fragments of the author’s long correspondence with Y. Dubrova, which may be of interest to biographers of F. Dobrzhansky, M. Tymofeiev-Resovsky, O. Sozinov, O. Yablokov, O. Kistiakowsky, as well as to students, teachers, and historians of Kyiv National University, Kaniv Nature Reserve, and the University of Leicester.
In silico docking study of selected compounds for its hepatoprotective activity
Authors: V. Moni Prashanth  , V. V. Rajesham  , P. Roshan Ali  , G. Supriya Reddy  , T. Rama Rao
Published: February 2024

Liver fibrosis is a condition characterized by the excessive accumulation of scar tissue in the liver. It is typically caused by chronic liver diseases, such as chronic viral hepatitis (e.g., hepatitis B and C), alcoholic liver disease, non-alcoholic fatty liver disease (NAFLD), autoimmune hepatitis, and certain genetic conditions. Ephrin receptor A2 (EphA2) is identified as potential anti-inflammatory target which influences inflammatory process and immune response, impacting the recruitment and activation of immune cells and as a host cofactor for Hepatitis C Virus (HCV) entry. Andrographolide a diterpenoid lactone, Scoulerine a natural alkaloid possess anti-inflammatory activity. The present work was done to evaluate anti-inflammatory activity of andrographolide and scoulerine using software Autodock 4.2. Phyto-constituents were fetched from the PubChem database. 3D structure of EphA2 were downloaded from Protein Data Bank (PDB). Among two phyto compounds, andrographolide had highest binding energy of -7.58 which is a clear evident of potential anti-inflammatory activity and prevent hepatic fibrosis. The active site of the target protein was predicted by using CASTP (Computed atlas of surface topography of proteins). Protein ligand interaction information is obtained by Protein ligand interaction profiler.
Healthy Singing Practices: An Analysis of Body Mapping Education on Undergraduate Vocalists
Authors: Stapleton Sarah
Published: February 2024

Abstract: Singers are unique among musicians because their instrument is their body. Undergraduate singers studying at Ontario universities participated in a study investigating the effectiveness of Body Mapping education for undergraduate-level voice students, in the belief that an understanding of the body aids a deeper understanding of singing, leading to enhanced performances, heightened personal discoveries, and reduced instances of injury. This article describes key findings of the study, including students’ experiences of greater ease and improved vocal function following Body Mapping, while panelists’ bias and their ability to rate students objectively was also observed. The article ends with the author’s observations of lessons learned as a new researcher.
Feminist psychology: Values and visions
Authors: Wilkinson Sue
Published: February 2024

In this paper, I offer an overview of the historical and international context within which feminist psychology has developed, locating my own work within this context. I suggest that feminist psychology encompasses a diverse range of research traditions, and I identify and briefly outline five of the main traditions within the field to date. These traditions are: the mismeasure of women; overcoming internalised oppression; listening to women’s voices; displacing sex differences; and reconstructing sex difference. Finally, I propose a key project for the future development of feminist psych ology: the exploration of issues relating to diversity.
Gender and BDSM revisited: Reflections on a decade of researching kink communities
Authors: Barker Meg
Published: February 2024

This paper reflects upon the ways in which my understandings of BDSM and gender have shifted over the past 10 years of studying kink communities. I begin with my early work on women who identified with both BDSM and femin.ism, and how they presented their positions. Then I touch upon ethical issues of how we research precarious communities, and our role as researchers in making certain narratives available or not. Following this, I summarise an analysis of a BDSM blog which complicates common views of female domination, and raises important questions about gejider in kink communities. Finally I mention my most recent work on shifting understandings of consent within kink communities, and how these are in line with certain strands of feminist thought, pointing to important directions for future research. Throughout the paper I endeavour to draw out implications both for research practice and for how we understand the operation of gender and power in kink communities and beyond.
Cultural cisgenderism: Consequences of the imperceptible
Authors: Kennedy Natacha
Published: February 2024

At the 2012 POWS Annual Conference, Natacha Kennedy delivered a powerful and challenging keynote on cultural cisgenderism. Her talk is reproduced here.
Cutting her nose to spite his face: Violence against women in India and the collusion of power
Authors: Soans Sonia
Published: February 2024

In the last few years crime against women in India has increased dramatically. What stands out about these crimes is how the perpetrators of these crimes use violence to disable a woman; through, for example, acid attacks, ‘honour crime’ and public stripping. The perpetrators often claim to do this in order to preserve their notion of ‘Indian culture’. These notions are tied within understandings of women’s roles as submissive, chaste, modest and ‘traditional’. Women’s bodies are the primary site for this violence as disfiguring the female body sends out a cautionary message to other women not to transgress boundaries that have been laid out by those who feel they must preserve this culture.

These understandings of ‘Indian culture’ are often invented and are tied to nationalism which poses a threat to ‘Westernised Indians’ particularly women. Cases such as the Delhi Gang Rape case or the attack on pubs in Mangalore which led to the ‘pink chuddi campaign’ have caught the eye of the media, however, one sees them being justified by the perpetrators on the grounds of protecting ‘Indian culture’. When these crimes are presented in the Western media they are often collude with the perpetrators of these crimes by using these notions of ‘tradition’. Western ideas of India and how Eastern values must be preserved from Western civilisation often undermine the victim’s ordeal.
INVESTIGATION OF THE HEPATOPROTECTIVE POTENTIAL OF FRACTIONS AND PHYTOSOMAL COMPLEXES OF TELFAIRIA OCCIDENTALIS HOOK F LEAF EXTRACTS ON ALCOHOL-INDUCED HEPATOTOXICITY IN RAT MODELS
Authors:   Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani – Enugu State, Nigeria, Omeh Romanus C. , Okolo Kenneth O. ,   Department of Pharmacology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani, Enugu State, Nigeria, Ugwueze Mercy E. ,   Department of Pharmaceutics and Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Enugu State University of Science and Technology, Agbani – Enugu State, Nigeria, Mbah Chukwuemeka C ,   Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria, Atamma Anthony A. ,   Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria, Momoh Mumuni A. ,   Department of Pharmaceutics, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria, Ogbonna Josephat I. ,   Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria, Ugorji Lydia O. ,   Department of Pharmaceutical Technology and Industrial Pharmacy, Faculty of Pharmaceutical Sciences, University of Nigeria, Nsukka, Enugu State, Nigeria
Published: February 2024

The aim of this work was to evaluate the hepatoprotective potential of fractions and phytosomal complexes of Telfairia occidentalis leaf extracts on ethanol-induced hepatotoxicity in rat models. Phytosomal complexes of ethanol extract fractions were prepared by the thin film hydration technique. Hepatoprotective activities were evaluated by biochemical assays and histopathological examination of liver sections. Intoxication of animals with pure ethanol significantly (p < 0.05) elevated their liver enzyme titers, whereas co-administration with various extracts and phytosomal complexes reversed the increases. Histopathological findings revealed liver tissue protective effects of the extracts with the phytosomal complexes exhibiting greater effects (p < 0.05). Significant differences at p ≤ 0.05 were observed in the liver indices of animals treated with co-administered ethanol and extract fractions or phytosomes complexes versus the positive control group. T. occidentalis leaf extract formulated as phytosomes, therefore, has good potential of enhancing the hepatoprotective activities of the extract.
MOLECULAR FIELD ANALYSIS AND DYNAMIC SIMULATION STUDIES OF 1,5-DISUBSTITUTED PYRAZOLINE-BASED MAO-A INHIBITORS FOR THE MANAGEMENT OF DEPRESSION
Authors:   Department of Pharmaceutical Chemistry, ISF College of Pharmacy, G.T. Road, Ghal Kalan, Mogato - 142 001, Punjab, India, Shome Abhimannu , Chawla Pooja A. ,   Department of Pharmaceutical Chemistry, ISF College of Pharmacy, G.T. Road, Ghal Kalan, Mogato - 142 001, Punjab, India, Rangra Naresh K. ,   Department of Pharmaceutical Chemistry, ISF College of Pharmacy, G.T. Road, Ghal Kalan, Mogato - 142 001, Punjab, India, Eyupoglu Volkan ,   Department of Chemistry, Cankırı Karatekin University, Cankırı Türkiye Cumhuriyeti - 18100, Rawat Ravi ,   School of Health Sciences & Technology, UPES University, Dehradun-248 007, Uttarakhand, India
Published: February 2024

Depression, along with grief and anxiety, is currently one of the most common mental illnesses. It was placed 25th among the major diseases. QSAR (CoMFA) of 37 compounds with MAO-A inhibitory activity yielded the most significant QSAR model, m.3, with r2 = 0.963, SDEC= 0.129, q2 = 0.742, SDEP= 0.34. Using the lead likeness matrix, thirty-seven 1,5-disubstituted MAO-A inhibitors were developed and tested based on the QSAR models. The top 13 compounds were identified. Furthermore, compound 2B (ΔG: -10.3 kcal mol-1, RMSD: 0.151 Å) was selected among the top 13 hits obtained from molecular docking experiments. Significant interactions were also observed, including π-π contacts with Phe208, Tyr444, Trp407, and hydrogen bond interactions with Ala68 and Tyr69. Furthermore, dynamic modelling demonstrated that compound 2B (0.11 nm) has higher overall stability than clorgyline, with a lower RMSD value, and may reach equilibrium in the final 20-25 ns. In terms of RMSF, 2B produced around 0.34 nm with less variation than clorgyline. Throughout the simulation, 2B (No. of H-bond: 6) had more hydrogen bonding than clorgyline (No. of H-bond: 3) with the highest occupancy, i.e. 117.39% for GLU216, 29% for TYR444, and 49% for PRO72, and so on. Compound 2B was proven to be the most essential throughout the experiments. These new chemicals will be optimized in vitro and in vivo in the future. This study will surely contribute to the development of novel MAO-A inhibitors for the treatment of depression.
DIALKYL ISOMERS OF BENZENESULFONAMIDPHENYLPYRIMIDINE-4(1H)-ONE: SYNTHESIS, STRUCTURE AND PHARMACOLOGICAL STUDIES
Authors:   Department of Pharmaceutical Chemistry and Drugs Technology, Federal State Autonomous Educational Institution for Higher Education, North-Caucasus Federal University, Stavropol, Russian Federation - 355017, Russia, Anenko Denis S. , Kodonidi Ivan P. ,   Department of Organic Chemistry, Pyatigorsk Medical and Pharmaceutical Institute - Branch of Volgograd State Medical University, Pyatigorsk, Russian Federation - 357532, Russia, Kirik Sergey D. ,   Nonferrous Metal Institute,Siberian Federal University, Krasnoyarsk, Russian Federation - 660075, Russia,   X-ray Laboratory, Institute of Chemistry and Chemistry Technology SB RAS, Krasnoyarsk, Russian Federation - 660036, Russia, Glizhova Tamara N. ,   Department of Pharmaceutical Chemistry and Drugs Technology, Federal State Autonomous Educational Institution for Higher Education, North-Caucasus Federal University, Stavropol, Russian Federation - 355017, Russia, Saidov Narzullo B. ,   Department of Pharmaceutical Chemistry and Pharmacy Management and Economics, Tajik National University, Dushanbe - 734025, Tajikistan
Published: February 2024

Interaction of N-acetyl-2-phenylacetamide with sulfanilamide and N-(2-phenylacetyl)propanamide with sulfanilamide led to the preparation of the two isomeric benzenesulfonamidphenylpyrimidin-4(1H)-ones. In positions 2 and 6, the synthesized phenylpyrimidin-4(1H)-ones contained methyl and ethyl as substituents in the first case (IIa), and ethyl and methyl – in the second one (IIb), respectively. The crystal structures of the compounds have been determined by X-ray powder diffraction. It has been established that the positions of substituents significantly affect the conformation of molecules. In molecule IIa, the phenyl ring is rotated to the pyrimidine one by 84°; in IIb, the both rings lie in the same plane. Due to different conformations, the packing of molecules in the crystal lattice changes significantly. Pharmacological properties of isomeric pyrimidinones have been studied in relation to the anti-inflammatory and cerebroprotective activity in chronic traumatic encephalopathy. A comparative analysis of the drug similarity has been carried out. Screening of anti-inflammatory and cerebroprotective activities has shown that compound IIa surpassed its structural isomer in the pharmacological action, which was interpreted as a greater elasticity result of molecule IIa compared to IIb due to the less extended π-system.
ENHANCING GASTRIC ULCER MANAGEMENT: NOVEL INSIGHTS FROM TERAZOSIN-PANTOPRAZOLE COMBINATION THERAPY
Authors:   Department of Pharmacology, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, V. M. Road, Vile Parle (W), Mumbai- 400 056, Maharashtra, India, Vadakutt Teresa J. , Doshi Gaurav M. ,   Department of Pharmacology, SVKM’s Dr. Bhanuben Nanavati College of Pharmacy, V. M. Road, Vile Parle (W), Mumbai- 400 056, Maharashtra, India
Published: February 2024

In this present study, we explored a novel approach to gastric ulcer management by investigating the therapeutic potential of terazosin, an alpha-1 adrenergic receptor inhibitor, in combination with pantoprazole, a common anti-ulcer agent. Employing an ethanol-induced rat-gastric ulcer model, the study demonstrated that terazosin pre-treatment significantly reduced ulcer formation, with the terazosinpantoprazole combination exhibiting superior mucosal protection compared to pantoprazole alone. Histopathological analysis revealed preserved mucosal structure and reduced neutrophil infiltration, indicating an anti-inflammatory effect. At a molecular level, the combination treatment groups exhibited elevated levels of phosphoglycerate kinase 1 (PGK-1), a vital enzyme in cellular energy metabolism, while inflammatory markers IκB kinase (IKK) and interleukin- 6 (IL-6) were significantly reduced, signifying mitigation of inflammation. These findings of the three different combinations of terazosin with pantoprazole indicate that this can be a potential approach for the treatment of gastric ulcers and can help in reducing the existing pantoprazole dose.
LIVING WITH THE GHOST: CAN WE EVER ESCAPE COVID-19’S SHADOW?
Authors: Chawla Pooja A. ,   University Institute of Pharmaceutical Sciences and Research Baba Farid University of Health Sciences, Faridkot, Punjab, India
Published: February 2024

Dear Reader, A strange virus flipped our world upside down, two and a half years ago, making us feel like we were living in a science-fiction film. Lockdowns, masks, and social isolation were all terms we had to learn. Uncertainty reigned supreme and terror became our constant companion. In 2024, a separate worry persists: Will we ever completely move on from COVID-19? We overcame COVID, but the next variant is JN.1. We don’t know about long-term immunity or “Long JN.1 effects,” but we must learn to live with it. More research, mental health assistance, healthcare reform and international collaborations are critical. It’s terrifying, but humans are strong. We can adapt and win again.
Os impactos da perfuração de poços artesianos no Cariri Oriental Paraibano: um estudo de caso no assentamento Serra do Monte Cabaceiras – PB
Authors: Da Silva José Erivaldo , Martins Maria de Fátima
Published: February 2024

A água é fator condicionante à vida e está diretamente ligada as relações sociais de poder, travada historicamente entre os homens. Sendo assim, tem sido objeto de discussões em debates nas conferências mundiais, especialmente relacionadas a Agenda 2030, objetivo de número seis, que discorre sobre a garantia, a disponibilidade e o manejo sustentável da água e do esgotamento sanitário. Em regiões semiáridas, as águas superficiais são mais escassas que o normal, sendo necessário recorrer ao uso das águas subterrâneas, a partir de poços artesianos, como forma de garantir a sobrevivência humana e animal. O objetivo desse trabalho foi mapear os poços artesianos existentes no Assentamento Serra do Monte no Município de Cabaceiras – PB, a partir de uma análise da política de recursos hídricos local, identificando os impactos na renda das famílias, sob a ótica da sustentabilidade e dos ODS – Objetivos de Desenvolvimento Sustentável. O trabalho fundamentou-se nos textos da Agenda-21, da Agenda 2030, Brasil (2023), ASA (2023), Blank (2008), ONU (2014), Queiroz Rezende (2015), Souza (2007), Azevedo (2015), Furtado (1967) e Gomes (2012). A pesquisa justifica-se pela necessidade de compreender e valorar os efeitos das políticas dos recursos hídricos, o desenvolvimento regional, local e sustentável, aos recursos hídricos e a capacidade das pessoas de participação na sociedade com potencial ao processo de desenvolvimento. Os principais resultados obtidos foram: melhoria da renda das famílias; ampliação nos anos de estudos dos filhos dos assentados, especialmente das mulheres; maior participação da renda por recursos oriundos da propriedade, que de fontes externas.
Importance
of quality control in sample preparation workflow of forensic degraded
samples for massively parallel sequencing (MPS)
Authors: Belakaposka Srpanova Viktorija , Risteski Sasho , Bitoljanu Natasha , Stankov Aleksandar , Jakovski Zlatko
Published: February 2024

Molecular genetic analyzes occupy a significant part of laboratory tests in forensic practice. Pre-prepared commercial kits used for DNA extraction are an excellent choice for samples provided by living people, but in forensic practice, most of the samples that undergo molecular processing are often degraded and may pose a challenge in the laboratory. A special challenge is to provide quality genetic material from post-mortem samples that would be suitable for further analysis with massively parallel sequencing. The aim of this paper is to evaluate the applicability of two silica-based DNA extraction methods for post-mortem blood samples with varying storage time and degrees of degradation, and also, to establish proper quality control in sample preparation workflow for Massively Parallel Sequencing using Ion Torrent GeneStudio™ S5 platform. The study was performed on 48 blood samples with different storage time. Silica-based DNA extraction protocols was applied and quantification was made using Qubit 3.0 fluorimeter, followed by Real-Time PCR quantification. The results indicate high variability between the obtained DNA quantities from post-mortem blood samples with different storage time. Correlation was determined between storage time and sample quantity and quality. The Qiagen Mini Kit & Micro Kit are applicable for DNA extraction from blood samples with various storage periods and degradation levels, which can be used for further NGS analyses after careful quality control and optimization of library preparation conditions.
Development of creative thinking of students by means of project activities
Authors: Анисимов Д.Г.
Published: February 2024

Развитие креативного мышления является важной составляющей обучения воспитанников кадетского военного корпуса, так как военная служба подразумевает работу в переменчивых и иногда экстремальных условиях, а военные технологии постоянно развиваются. Креативное мышление способствует развитию лидерских навыков (способность к инновациям, умение вдохновлять и мотивировать других, умение принимать ответственные решения в сложных ситуациях), помогает кадетам более эффективно управлять ресурсами в сложных условиях и принимать обоснованные решения, основанные на творческом подходе. Авторами представлен взгляд на проблему развития креативности средствами групповых и индивидуальных проектов на предметах социально-гуманитарного цикла. Результаты исследования помогают понять, как развивать креативное мышление у обучающихся, чтобы они могли успешно адаптироваться к быстро меняющемуся миру и успешно решать новые проблемы, как выявить факторы, влияющие на развитие креативности у обучающихся кадетского военного корпуса, какие именно методы проектного обучения наиболее эффективны, а именно проблемный подход, самостоятельность, работа в команде, анализ и синтез информации, наличие исследования, поиск инновационных решений. Охарактеризован принцип подбора пакета диагностических методик, позволяющих оценить уровень креативного мышления.

The development of creative thinking is an important component of cadet military education, as military service involves working in variable and sometimes extreme conditions, and military technology is constantly evolving. Creative thinking contributes to the development of leadership skills (ability to innovate, ability to inspire and motivate others, ability to make responsible decisions in complex situations), helps cadets manage resources more effectively in complex environments and make informed decisions based on creativity. The authors present a view on the problem of creativity development by means of group and individual projects in the subjects of social and humanitarian cycle. The results of the study help to understand how to develop creative thinking in schoolchildren so that they can successfully adapt to the rapidly changing world and successfully solve new problems, how to identify the factors influencing the development of creativity in students of the military cadet corps, what exactly are the most effective methods of project-based learning, namely problem-based approach, independence, teamwork, analysis and synthesis of information, availability of research, search for innovative solutions. The principle of selecting a package of diagnostic techniques to assess the level of creative thinking is characterized.
Learning by Gaming: Investigating the Effectiveness of Kahoot! on Young ESL Learners’ Language Performance
Authors: Navinkumar Akshaya , B Sivakami
Published: February 2024

Educators turn to game-based language education to offer immersive and interactive learning experiences that foster language acquisition. This fun and engaging mode of learning is resultant of the rapid growth of technology and the rising popularity of internet-based games. The present study investigated the effectiveness of gamification of Kahoot! to enhance grammar acquisition of young ESL learners. In a pre-experimental quantitative research setting, a purposive sample of 68 sixth-grade ESL learners is utilized, employing research instruments like pre-tests, post-tests, and questionnaires to evaluate the efficacy of gamified learning for grammar acquisition. The SPSS analysis suggests a statistically significant improvement in students' post-test scores in grammar, affirming Kahoot!'s positive impact on student motivation and engagement. This study strongly highlights gamification as a powerful strategy in enhancing language acquisition and nurturing a positive learning experience.
Exploring Lexico-grammatical Patterns in Doctoral Dissertations: A Multidimensional Analysis
Authors: Abdulhaleem Ebtesam , Ali Sadia
Published: February 2024

Doctoral dissertations occupy a prominent place in academic communication and advancement. This genre applies its intricate lexical and grammatical patterns to shape its effectiveness and these patterns need to be studied. The study aims to investigate the discussion section of the doctoral dissertations from ten leading British universities. The objective of the study is to explore the lexico-grammatical similarities and differences between ELT and Linguistics dissertations. It also attempts to analyze how far the lexico-grammatical choices used in the discussion section of ELT dissertations are similar to or different from those of Linguistics. The corpus used in this study consists of 200 discussion sections: 100 from ELT and 100 from Linguistics. A random sampling technique was used to collect data which consisted of publicly available dissertations. Biber’s Tagger was used to annotate grammatical and lexical features. To find out the significant interaction between the selected disciplines, a factorial ANOVA was used. The study is significant in terms of providing insight into the preferred lexico-grammatical patterns used by the students. It further explains how two different disciplines – Linguistics and ELT, make various lexico-grammatical choices. The findings of the study will help the researcher from around the world, particularly the ones from non-English speaking countries, in terms of familiarizing them with the conventions involved in writing a dissertation.
The Effects of Using Scientific Genre to Promote Undergraduate Students’ English Academic Writing in an ESP Course
Authors: Khammee Kultida , Liang-itsara Apiwit , Nomnian Singhanat , Rhee Seongha
Published: February 2024

Argumentative writing is problematic for Thai EFL learners. This study aims to determine the effects of an argumentative correspondence writing course in an ESP for Science classroom. The course was designed from the genre-based approach, including stance and engagement by Hyland (2005) and ESP material design by Hutchinson and Waters (1987). The experiment involved 40 participants studying in a science field in a public university in Thailand. The study used a one-group pretest and posttest design. The research instruments were a knowledge test and a writing test for scientific argumentative correspondence. The results revealed statistically meaningful differences between the pretest and posttest scores, indicating that the students increased their abilities and gained higher test scores through completing the course. The findings suggest that instruction of writing scientific argumentative correspondences is effective and should be included in ESP science courses, especially as a foundation for writing longer texts in scientific genres.
Pengenalan Prinsip Kaizen Dan Penanganan Barang Berbahaya (Dangerous Goods) pada PT. Kereta Api Logistik (KALOG) di Jakarta Pada Tahun 2020
Authors: Lesmini Lis , Rizaldy Wynd , Chaerudin Irwan
Published: February 2024

PT. Railway Logistics (KALOG) as a partner in this PKM is a company engaged in the field of rail-based freight transportation with business fields in the form of logistics distribution, container terminal management, loading and unloading, warehousing, packing, labeling, transportation, tracking, logistics escort and logistics management. The problem of partner priority is the lack of human resources who understand specifically about the application of Kaizen principles and the handling of dangerous goods, especially for the delivery of goods by train. The purpose of this activity is; Provide basic knowledge of kaizen principles, handling dangerous goods and the formation of a profitability mindset for employees. The event was held on Thursday, March 12, 2020 at the Office of PT. KALOG, Railway Warehousing Complex, Kp Bandan Rt. 2/4, Jakarta 14430. Methods of Activities with training, Q&A and video playback. The stages of the activity are: a. Stage of Proposal Making, b. Survey Stage: Review of the location of devotion to PT. KALOG and conducted an interview with the Chairman of PT. Local KALOG, c. The stage of identification of partner problems and identification of equipment needs for socialization, d. Stages of Implementation of activities and the final stage, namely the creation of reports and articles of PKM journals. The result of this activity is the increasing knowledge and understanding of participants about the importance of applying the principles of Kaizen and Dangerous Goods in creating profitability and safety and security of freight by train. Participants of the activity are 26 people consisting of leaders, employees and stake holders from PT. KALOG numbered plus 4 Lecturers and 5 ITL students The survey results showed that socialization was effective because it was able to increase the knowledge and understanding of participants in the principles of Kaizen and Dangerous Goods in handling goods, especially by train
curso “Aspectos da Cultura Brasileira” do Programa de Português para Estrangeiros da UFPel
Authors: Röpke da Silva Lucas , Doumid Damasceno Vanessa , Selbach Helena Vitalina , Rezende Ramires Helena
Published: February 2024

Este trabalho tem o objetivo de apresentar o curso "Aspectos da Cultura Brasileira", ofertado pelo Programa de Português para Estrangeiros da Universidade Federal de Pelotas. O curso, que enfoca aspectos culturais das diferentes regiões do Brasil por meio de gêneros discursivos, integra as ações de ensino da instituição voltadas à internacionalização, ao acolhimento e à formação em língua portuguesa de falantes de outras línguas. Apresenta-se os pressupostos teórico-metodológicos que embasam o curso para, então, analisar-se as tarefas de um exemplar de plano de aula sobre a Região Centro-Oeste que se constitui em um exemplar de ação docente que proporciona, aos alunos, a oportunidade de se engajar em práticas sociais consoante com a noção de indissociabilidade entre língua e cultura. A partir da reflexão sobre as práticas de ensino e aprendizagem específicas do contexto descrito, espera-se contribuir com as discussões da área de Português como Língua Adicional no que diz respeito à atividade docente e à construção de tarefas.