bluuebunny/crossref_metadata_2025 huggingface dataset:
IMPLEMENTASI KEBIJAKAN PEMERINTAH DALAM MERESTRUKTURISASI ORGANISASI PERANGKAT DAERAH (OPD) DI KOTA PALEMBANG
Authors: Syarif Imran
Published: March 2024

Penataan organisasi Perangkat Daerah yang dilakukan oleh seluruh pemerintah daerah berdasarkan Peraturan Pemerintah Nomor 18 tahun 2016 membuat pemerintah daerah mengambil kebijakan berupa adanya perubahan Susunan Organisasi Tata Kerja di Kota Palembang. Tujuan dari penelitian ini adalah mengetahui implementasi restrukturisasi di dalam dunia struktur dan tatanan birokrasi di kota Palembang. Berdasarkan hasil penelitian, pasca implementasi Peraturan Pemerintah Nomor 18 tahun 2016, pemerintah kota Palembang tidak mengalami perubahan struktur organisasi secara signifikan, akan tetapi hanya merubah di bidang secretariat yang sebelumnya belum memiliki tugas dan fungsi secara jelas dan teraarah. Selain itu, restrukturasi di kota Palembang, terjadi pada perubahan nama dinas, dan lebih mengitegrasikan kepada satu dinas. Oleh karena itu, implementasi PP. No. 18 tahun 2016, implementasi terhadap perampingan struktur pada bidang OPD, pada kenyataan tidak memiliki perubahan yang signifikan. Justru, pemerintah kota Palembang hanya merubah nama dinas daerah kota saja. Disamping itu, upaya pemerintah melalui restrukturisasi OPD, bertujuan dalam mewujudkan sebuah birokrasi “miskin struktur, kaya fungsi”. Hal ini sesuai dengan paradigma rasionalisme kritis dalam mewujudkan sebuah tatanan birokrasi yang ramping, mini namun dihuni oleh tingkat efektifitas dan profesionalisme yang tinggi.
Effectiveness of the Spatial Domain Techniques in Digital Image Steganography
Authors: Selvamani Rosshini , Yusoff Yusliza
Published: March 2024

Digital steganography is a new and extremely demanding method for transmitting information securely over the internet while employing a covert device. Since its inception in the 1990s till the present, digital steganography has a lengthy history. Early steganography focused primarily on imperceptibility, security and embedding capacity. In addition to using statistics as a foundation, convolution neural networks (CNN), generative adversarial networks (GAN), coverless approaches, and machine learning are all used to construct steganographic methods. Robustness is becoming a crucial component of many innovative techniques. Spatial, Transform, and Adaptive domains serve as the understructure of those novel methods. This broadens the range of steganographic technique development and often concentrates the implementation of adaptive techniques. As a result, this study helps to analyze the fundamentals of image steganography, a comparative review on the spatial domain algorithms. As using evaluation tools is strongly tied to the effectiveness of steganography, this study also goes into great detail about its application. The purpose of this research is to determine the best and most effective algorithm among the three competitive spatial domain algorithms, which are Least Significant Bit (LSB), Optimum Pixel Adjustment Procedure (OPAP), and Pixel Value Differencing (PVD) which in regard demonstrated the efficacy of spatial domain algorithms.
Improved Ozone Level Detection through Feature Selection with Modified Whale Optimization Algorithm
Authors: L. Y. Yab , Wahid Noorhaniza , A Hamid Rahayu
Published: March 2024

This study presents a new approach for ozone level detection through feature selection by the modified Whale Optimization Algorithm (mWOA). This study aims to enhance the accuracy and efficiency of ozone level prediction models by selecting the most informative features from the dataset. As air quality deterioration poses significant risks to both human health and ecological equilibrium, pinpointing relevant features becomes essential for boosting prediction accuracy. The scope of the research includes comparing the performance of mWOA with the original WOA in two feature selection techniques: filter-based and wrapper-based. The experiments run proposed approaches on a multivariate time-series dataset with 20 repetitions. The evaluation criteria include processing time, number of features selected, and classification accuracy obtained by the kNN classifier. The statistical results demonstrate the effectiveness of the proposed mWOA approach, outperforming WOA due to the modified control parameter that enables a more precise exploration of the search area. The findings of this study reveal the improved performance of mWOA in selecting informative features, resulting in better prediction on average: 93.75% for filter-based and 94.49% for wrapper-based. In conclusion, the wrapper-based feature selection using the mWOA approach proves to be a valuable asset in enhancing the accuracy and efficiency of ozone level detection models. In the future, the proposed technique can be used for more applications in environmental science and engineering research.
Comparative Analysis of Process Innovation Strategies: A Study of Family and Non-Family Indian IT Firms
Authors: K. R. Phani , Mukul Kumar
Published: March 2024

This conceptual paper delves into the dynamic realm of process innovation within the Indian Information Technology (IT) sector, scrutinizing the unique strategies and methodologies adopted by both family and non-family-owned firms. Employing a comprehensive analysis, we aim to uncover distinct approaches employed by these entities to drive and effectively implement process innovation. This paper contributes valuable insights into the intricate interplay of familial structures and corporate innovation, shedding light on how these factors shape the trajectory of technological advancements in the Indian IT landscape.
Light Transmitting Concrete
Authors: Prof. Radha Ajay Powar  , Sanika Dilip Mohite  , Sonam Ashok Salavi  , Yogesh Nandkumar Patil
Published: March 2024

This paper reviews the Light Emitting Concrete. The increase in population leads to the growth of construction sector and hence construction activities increases day by day. Construction of tall storied and multi storied buildings result in obstructing natural light in the building, thus leading to increase in artificial light. Light-transmitting concrete has property of passing artificial as well as natural light due to optical fibers present in it. Light Transmitting concrete, also known as translucent concrete. Light –transmissive properties due to embedded light optical elements. This paper describes historical development of Light Transmitting concrete. Light transmitting concrete (LTC) or ‘LiTraCon’ is an example of such phenomenal innovation. The aim is to promote translucent concrete as an attractive, promising, and innovative building material for the construction industry
NARRATIVE REVIEW AND ERIKSONIAN-SYNTHESIS OF LESSONS FROM ANIMALS: MUTUALITY OF RECOGNITION IN THE AGE OF THE PSEUDO SPECIES.
Authors:   , Wannenburg Nicola , Gasson James , Niekerk Roelf van
Published: March 2024

Violence in society has become more pervasive in all facets of life and is often rationalized by the formation of ‘unique identities’. Homes, communities, and places of education have all been implicated. On-going violence and destruction also lead to issues surrounding the sustainability of the environment and the potential long-term impact on humans and animals. Despite technological advancement making the world a smaller place, it has not necessarily brought people together. Increased alienation from the self as well as other people and nature has been associated with decreased stability and increased psychological distress. Post the Covid-19 pandemic there has been a call for greater focus on One Health, which views the health of humans, animals, and nature as interlinked. Animals as aids for healing is ever increasing in medical and therapeutic settings. Increased focus on retaining the healing aspects of nature and relationships with animals in an ever-changing society and technological world may assist a move to a holistic approach to living, education, and ethical treatment of others and the environment. Further research is needed on children's and adults’ understanding of affective empathy and ethical action. Research as well as guidance on the ethical treatment of others may inform school curriculums and may encourage an ethical stance to policy development as well as implementation. An Eriksonian synthesis on lessons from animals regarding mutuality of recognition in an ecologically bound universe is offered as one lesson and philosophy that may facilitate ethical thinking and action.
Penerapan UI/UX Jahit Buk Las di Kota Pekanbaru Menggunakan Metode Lean UX
Authors: Iyan Julian Nanda Mardiwanto , Rizki Muhammad , Eiva Fathda Syarifah
Published: March 2024

Menjahit adalah pekerjaan menyambung kain, bulu, kulit binatang, pepagan, dan bahan-bahan lain yang bisa dilewati jarum jahit dan benang. Menjahit dapat dilakukan dengan tangan memakai jarum tangan atau dengan mesin jahit. Orang yang bekerja menjahit pakaian disebut penjahit. Penjahit pakaian pria disebut tailor, sedangkan penjahit pakaian wanita disebut modiste. Masyarakat merasakan dampak akibat pemberlakuan serta pembatasan yang dilakukan pemerintah, yaitu kesulitan memenuhi kebutuhan yang harus dilakukan secara langsung sehingga harus berpindah menjadi online.

Namun juga banyak hal yang menjadikan jasa menjahit kurang diminati masyarakat sebelum pandemi yaitu oleh berbagai hal yaitu lokasi yang tidak diketahui atau jauh, pesanan kurang luas yang hanya terdiri dari orang sekitar, jahitan tidak sesuai keinginan konsumen dan waktu jahit yang lama. Untuk mengatasi permasalahan tersebut diperlukan aplikasi mobile membantu masyarakat sehingga diperlukan solusi untuk membantu menghubungkan antara penjahit dan masyarakat secara luas sebagai calon pelanggan. Untuk mewujudkan solusi tersebut peneliti mengusulkan desain solusi aplikasi jahit untuk membantu masyarakat menemukan penjahit sesuai keinginan dan kebutuhan.

Metode lean UX adalah metode yang merubah proses yang panjang menjadi singkat yang memiliki keberhasilan dan proses yang sangat cepat dan berfokus pada peningkatan pemahaman pengguna tentang design yang dirancang. Aplikasi ini akan memudahkan pengguna melakukan pemesanan pada Aplikasi Jahit Buk Las.
Perancangan Sistem Informasi Pemesanan Menu Berbasis Android
Authors: Niesa Chaeroen , Mutasar Mutasar , Hasanah Uswatul
Published: March 2024

MC Coffe Bireuen merupakan suatu tempat yang dikunjungi pelanggan untuk berbelanja makanan dan minuman, bisnis restoran sudah begitu banyak di minati oleh masyarakat pada umumnya, karena selain memiliki omset yang bagus juga mudah berkembang. Kondisi di MC cafe saat ini masih menggunakan cara memesan secara manual dan pembebasan penggunaan akses internet oleh pelanggan. Hal tersebut menyulitkan pemilik cafe dalam pengeluaran biaya tagihan akses internet, di tambah dengan sistem pembayaran pun masih manual yang menyebabkan perhitungan cukup memakan waktu. maka dirancang sebuah website lokal dan sistem manajemen penggunaan akses internet yang mampu memberikan solusi dalam mengerjakan layanan pemesanan. Pada rancangan sistem aplikasi ini menyediakan menu pemesanan secara android agar memudahkan bagi pelanggan maupun pekerjanya dalam menangani pemesanan maupun pembayaran.

Kata Kunci : Cafe, Sistem Informasi, Web, Android, Codeigniter
Rancang Bangun Alat Monitoring Suhu Blood Bank Refrigerator Dengan Sistem Database
Authors: Soeparli Alian Jerly , Muhtar Muhtar , Ruhyana Lili , Gunawan Gunawan
Published: March 2024

Blood Bank Refrigerator adalah peralatan yang digunakan sebagai pendingin. Biasanya alat ini digunakan untuk menyimpan darah, dan berbagai produk darah seperti plasma, trombosit, dan sel darah merah. Blood Bank Refrigerator dapat mempertahankan kualitas produk darah meskipun disimpan dalam waktu yang lama. Suhu yang tidak sesuai dapat membuat darah menggumpal atau pecah, sehingga tidak aman untuk diberikan kepada pasien. Masalah pada blood bank referigator yaitu tidak bisa dimonitoring, dan saat ini pemantauan suhu pada kulkas penyimpan darah masih dilakukan mandiri dengan mencatat manual.Berdasarkan uraian diatas, pada Tugas Akhir ini penulis akan membuat alat monitoring suhu  blood  bank referigator berbasis database. Penelitian ini menggunakan  metode System Development Life Cycle (SDLC) adalah proses pembuatan dan  pengubahan sistem serta model dan metodologi yang digunakan untuk mengembangkan sebuah sistem. Pada pengukuran suhu dilakukan dengan nilai 4°C  yang ditampilan pada  LCD dan database. Menggunakan waktu rata-rata 12 menit dan pengukuran setiap 2 menit pengujian sebanyak 6 kali dari 2 blood bank refrgator didapatkan rata-rata selisih kurang dari 0,2°C . Setelah dilakukan pengujian dan pendataan modul, dapat disimpulkan bahwa modul dan program berjalan dengan baik sesuai dengan perencanaan.
Gestión por procesos y pago a proveedores en una empresa de electrificación peruana
Authors: Arce-García Karoline , García-Vásquez Koraly Ximena , Ruiz-Saavedra Fernando
Published: March 2024

La investigación tuvo como objetivo determinar la relación entre la gestión por procesos y el pago a proveedores de la empresa Electro Oriente S.A. Se adoptó un enfoque de investigación básica con un diseño no experimental de nivel descriptivo correlacional. La población muestral consistió en 75 proveedores de la empresa mencionada. Se empleó la técnica de encuesta, para la cual se diseñaron dos cuestionarios estructurados y estandarizados para recopilar datos. Los resultados revelaron que el 40% de los proveedores calificaron la gestión por procesos como regular, mientras que el 36% la consideraron malo y un 24% la valoró como buena. En cuanto al grado de pago a proveedores, el 52% lo calificó como regular, el 22,7% como malo, y el 25,3% como bueno. Se concluye que dado el coeficiente de correlación Rho de Spearman de 0,182, existe correlación positiva muy baja entre la gestión por procesos y el pago a proveedores.
Análisis financiero y toma de decisiones en una empresa peruana de servicios turísticos
Authors: Solsol-Chávez Javier , García-Vásquez Koraly Ximena , Ruiz-Saavedra Fernando
Published: March 2024

Esta investigación buscó examinar la relación entre el análisis financiero y la toma de decisiones en la empresa de servicios turísticos Rioja EIRL, ubicada en el distrito de Rioja, Perú, durante los períodos 2019-2020. Para ello, se empleó un estudio de tipo básico, enfoque cuantitativo, nivel correlacional y diseño no experimental. La muestra consistió en 20 empleados, y para la recopilación de datos se utilizaron cuestionarios y análisis documental. Los resultados revelaron una correlación significativa entre el análisis horizontal, vertical y financiero, así como entre el análisis financiero y la toma de decisiones, con coeficientes de correlación de Spearman de 0,721, 0,594, 0,658 y 0,671 respectivamente. Además, se observó que todos estos coeficientes de correlación tuvieron un p-valor inferior a 0,05. En conclusión, se establece que existe una correlación positiva entre el análisis financiero y la toma de decisiones.
New possibilities of artificial intelligence in medicine: a narrative review
Authors: Litvin A. A. , Stoma I. O. , Sharshakova T. M. , Rumovskaya S. B. , Kyovalev A. A.
Published: March 2024

The purpose of the narrative review is to provide a descriptive analysis of the emerging capabilities of artificial intelligence (AI) to improve the diagnosis, prevention and treatment of various diseases.

   The article discusses which modern AI tools can be used in clinical practice, healthcare organization and medical education. The paper considers various aspects of medical AI systems, which are mainly computer support systems for medical decision-making in the process of clinical work. Much attention is paid to the possibilities of generative AI in medicine. Potential applications of AI in clinical practice have been investigated, highlighting promising prospects for both practitioners and their patients. The limitations associated with the use of AI in various fields of medicine are described, and possible ways of solving them are suggested. The problems of information security and ethical constraints associated with the introduction of AI are outlined. The broad integration of AI into public health will enhance clinical and management decision support, speed up disease diagnosis, and improve the overall quality and accessibility of healthcare services.
Comparative evaluation of the biological activity of quercetin-like compounds
Authors: Tsymbal D. O.
Published: March 2024

Objective. To determine the degree of manifestation of antioxidant, oncoprotective, anti-inflammatory properties of quercetin-like compounds of a number of flavonoids based on a comparative analysis of the complexing activity of oxygen-containing functional groups.

   Materials and methods. Analysis and systematization of literary data, a rationalistic method of modeling the properties of molecular systems.

   Results. The expediency of determining the structural identity of separate sections of molecules of various flavonoids for the subsequent determination of the degree of correlation of their biological properties is shown.

   Conclusion. Comparison of biological properties of substances of plant origin in combination with application of the latest extraction methods will help to accelerate drug development at the stage of obtaining a new active substance.
Unresolved issues in the use of imaging techniques in COVID-19-associated lesions of the stomach intestine
Authors: Yurkovskiy А. М. , Boika M. A.
Published: March 2024

Objective. To systematize and analyze data on the use of imaging techniques in COVID-19-associated gastric and intestinal lesions.

   Materials and methods. An analysis of publications in PubMed, EMBASE and Web of Science systems was carried out in the period 2020-2023, describing the use of imaging techniques in patients with a confirmed diagnosis of COVID-19-associated gastrointestinal lesions.

   Results. The most frequent signs of COVID-19-associated gastric and intestinal lesions on abdominal imaging were identified, their incidence and approximate diagnostic significance were evaluated.

   Conclusion. The use of computed tomography and ultrasonography for the diagnosis of COVID-19-associated gastrointestinal lesions is hampered by the lack of clear ideas regarding the sensitivity, specificity, and prognostic value of the previously described radiologic signs of gastrointestinal lesions. In addition, there is no clear algorithm for the use of imaging methods in COVID-19-associated abdominal pain syndrome. The solution of these issues will optimize the use of imaging methods and reduce the time of diagnostic search.
Ultrasound predictors of outcome of traumatic brain injury
Authors: Markevich D. P. , Viktorovich N. E. , Denisenko T. V.
Published: March 2024

Objective. To evaluate the possibility of ultrasound monitoring of optic nerve sheath diameter and blood flow velocity in cerebral arteries as predictors of craniocerebral trauma outcome.

   Materials and methods. 35 patients with traumatic brain injury (TBI) were produced ultrasound monitoring of the optic nerve sheath diameter (ONSD) and blood flow velocity (BFV) in the middle cerebral artery (AMC) before surgery and for 10 days after craniotomy. A comparative analysis of blood flow in the A MC and ONSD was carried out between groups of patients with a favorable (group 1) and unfavorable (group 2) outcome of TBI.

   Results. Between the groups of patients with different outcome`s TBI, significant differences were revealed in the diameter of the optic nerve sheaths at the preoperative period and in the diastolic blood flow velocity in the MCA on the 9th day after surgery. In group 1, the ONSD was 4.7 [4.5; 5.1] mm, and in group 2 – 5.6 [5.4; 6] mm, p=0.003. On the 9th day after surgery, BFV at diastole in group 1 was 43.9 [38.7; 49.4] cm/sec, in group 2 – 28.7 [24.8; 36.7] cm/sec, p = 0.001. For ONSD in the preoperative period as a predictor of unfavorable outcome of TBI AUC=0.83, Se=88.8%, Sp=61.2%. For diastolic BFV in the AMC on the 9th day after surgery – AUC = 0.84, Se=93%, Sp = 52 %.

   Conclusion. In patients with traumatic brain injury, ultrasound examination shows that the diameter of the optic membranes before surgery is ≥5.6 mm and the blood flow velocity in the middle cerebral artery in diastole ≤28.7 cm/sec can be considered as predictors of an unfavorable outcome of TBI.
Features of structural and geometric cardiac remodeling in patients with diabetes mellitus depending on chronic kidney disease stages
Authors: Vasilkova V. N. , Pchelin I. Yu. , Naumenava Ya. L. , Borovets Ya. A. , Yarets Yu. I. , Mokhort T. V.
Published: March 2024

Objective. To study the features of structural and geometric cardiac remodeling in patients with diabetes mellitus (DM) depending on the stage of chronic kidney disease (CKD).

   Materials and methods. We examined 499 patients (127 men and 322 women) with type 1 DM (133 people) and type 2 DM (316 people) aged 62 [52;69] years. The comparison group consisted of 65 randomly selected volunteering individuals (54 women and 11 men) without disorders of carbohydrate metabolism and kidney damage aged 59 [46;66] years. The laboratory examination of the patients included the measurement of serum creatinine, eGFR according to the CKD-EPI equation. An echocardiographic investigation was performed to study structural and geometric heart parameters. Left ventricular hypertrophy (LVH) was diagnosed when the left ventricular myocardial mass index (LVMI) exceeded 115 g/m2 in men and 95 g/m2 in women.

   Results. LVH was detected in 57.7 % of patients with DM, while in the comparison group – in 35.4 %. The frequency of LVH increased with a decrease in eGFR and was diagnosed in 100 % of cases with CKD 5. In patients with DM, the left ventricular concentric remodeling significantly predominated (29.2%). Multiple linear regression analysis demonstrated the influence of age (ß=0.30, p=0.01) and serum creatinine (ß = 0.15, p < 0.0001) on the LVMI, independent of other factors, which confirms their independent pathogenetic significance.

   Conclusion. Thus, patients with DM regardless of the CKD stage have structural and functional changes in the LV myocardium. Regardless of the nitrogen-excretion function of the kidneys, the predominant pattern of LV remodeling is concentric. The study of the features of structural and functional restructuring of the left heart in patients with diabetes should be taken into account in determining the cardiovascular prognosis.
Comparative assessment of hemodynamic parameters during anesthesia in orthopedic and traumatological operations on the lower extremities in children
Authors: Rozin Yu. E.
Published: March 2024

Objective. To conduct a comparative analysis of hemodynamic parameters during orthopedic and traumatological operations on the lower extremities in children performed under conditions of multicomponent balanced general and combined anesthesia.

   Materials and methods. A single-center prospective study. The present study included 60 children aged 6 to 17 years who underwent planned orthopedic and trauma surgery interventions on the lower extremities. Patients were divided into two groups depending on the method of anesthesia: Group 1 (n = 25) - multicomponent balanced general anesthesia, Group 2 (n = 35) - combined anesthesia (multicomponent balanced general anesthesia in combination with regional blocks of the sciatic and femoral nerves). To solve these problems, a comparative analysis of heart rate, systolic, diastolic and mean arterial blood pressure was carried out at seven stages of the study: 1st stage - initial, child on the operating table; 2nd stage - induction of anesthesia; 3rd stage - placement of the laryngeal mask; 4th stage - start of the operation; 5th stage - traumatic stage of the operation; 6th stage - completion of the operation; 7th stage - after removal of the laryngeal mask.

   Results. In all cases, the surgical interventions were successful. The study found that in the group of children who underwent multicomponent general anesthesia at the 4th (start of surgery), 5th (traumatic stage of surgery) and 6th (end of surgery) stages, heart rate (HR) was higher compared to the group of combined anesthesia. Systolic and mean arterial blood pressure during the traumatic phase of surgery were also higher in children undergoing multicomponent general anesthesia. The values of diastolic blood pressure did not differ between groups throughout the study with the exception of the 3rd stage (laryngeal mask placement) where lower values were observed in patients of the Group 1. Diastolic blood pressure values did not differ between groups throughout the study, with the exception of 3th stage (laryngeal mask placement), where lower values were noted in Group 1 patients.

   Conclusion. Combined methods of anesthesia based on the combination of multicomponent general anesthesia and conductive peripheral nerve blocks provide the greatest hemodynamic stability during orthopedic and traumatologic surgeries on the lower extremities in children.
The significance of light chronodestruction in the development of the embryotoxic effect in the experiment
Authors: Pashinskaya E. S. , Sobolevskaya I. S. , Pashinskaya A. K. , Ignateva I. V. , Pobyarzhin V. V. , Sobolevsky S. L. , Chicherova K. A.
Published: March 2024

Objective. To assess the significance of light chronodestruction in the development of the embryotoxic effect in the experiment.

   Materials and methods. The experiment was conducted on 60 female rats of the Wistar line. To assess the significance of chronodestruction in the development of embryotoxic effect, the uterus was isolated in the experiment, in which the number of implantation sites, the total number of embryos, the number of live and dead embryos, and the number of resorptions were estimated. The number of corpus luteum in the harvested ovaries was estimated. In addition, the mean embryo weight (g) and mean craniocaudal size (mm) were recorded. Indicators of embryotoxic effects of light deprivation were determined by pre- and post-implantation death, which was calculated in accordance with methodological recommendations.

   Results. Exposure to light deprivation reduces the number of implantation sites as of 7th, 14th and 21st days by 1,5-1,8 times, the total number of embryos by 1,6-1,8 times, the number of living embryos by 2,2-9 times and increases the number of dead embryos as of 14th and 21st days by 4-5,5 times, the number of resorptions – 1,6-11 times. The average craniocaudal size (mm) of embryos in experimental animals was recorded below control values by 1,5 times, 1,3 and 3,7 times by 7th, 14th, 21st days respectively. In females exposed to light deprivation, there was a significant increase in pre-implantation mortality by 35-41,8 times and post-implantation mortality by 7,2-20,4 times compared to the control.

   Conclusion. Light deprivation may have a negative effect on pregnancy and fetal development in female rats, which is confirmed by an increase in pre- and post-implantation mortality.
Methods of intrinsic and probe fluorescence in assessment of the effect of therapeutic radiation doses in vitro on the albumin molecule
Authors: Puzan N. D. , Cheshik I. A. , Belyakovsky V. N.
Published: March 2024

Objective. To study in vitro the effect of therapeutic doses of radiation on the albumin molecule using intrinsic and probe fluorescence methods.

   Materials and methods. In order to study radiation-induced changes in serum albumin during in vitro irradiation with therapeutic doses (2 Gy, 40 Gy and 70 Gy), the study was conducted in 2 directions: therapeutic doses of ionizing radiation irradiated a buffer, which was then used to prepare an albumin solution (pre-irradiation of the buffer); therapeutic doses of ionizing radiation irradiated an albumin buffer solution. The presence of structural and functional (conformational) changes in the albumin molecule was judged by changes in the values of intrinsic (λexc=280 nm) and probe (λexc=280nm, λexc=320 nm) fluorescence. Statistical processing of the obtained data was carried out using the program GraphPad Prism 6.0.

   Results. Irradiation with therapeutic doses of 2 Gy, 40 Gy and 70 Gy causes conformational changes (a statistically significant decrease in fluorescence intensity) in the albumin molecule, both during preliminary irradiation of the buffer solution used later for the preparation of albumin, and during irradiation of the buffer solution of albumin.

   Conclusions. Quantitative changes in the fluorescence intensity, both intrinsic and probe, differ under different modes of albumin irradiation.
Changes in energy metabolism of rat myocardium during exposure to ionizing radiation
Authors: Koval A. N.
Published: March 2024

Objective. To study the effect of incorporated 137Cs on the energy metabolism of the myocardium of white rats.

   Materials and methods. The work was carried out on 8 male white rats divided into 2 experimental groups, which were fed products contaminated with 137Cs for 7 days. Polarography was used to study the rate of oxygen consumption by myocardial tissue preparations on endogenous substrates, with the addition of exogenous succinic and glutamic acids, and with the addition of an uncoupler of oxidative phosphorylation, 2,4-dinitrophenol.Results. An increase in the rate of respiration on endogenous substrates caused by the uncoupling of oxidative phosphorylation was noted. At the same time, no statistically significant change in the amount of endogenous substrates was found.

   Conclusion. The revealed violation of energy production in the myocardium of experimental animals is caused by the uncoupling of oxidative phosphorylation, and can be explained by a change in the operation of potassium channels, which can explain the development of cardiovascular pathology under the action of ionizing radiation.
Study of the sensitivity of methicillin-resistant Staphylococcus aureus to antibiotics and bacteriophage preparations
Authors: Lagun L. V. , Kulvinsky Ya. A. , Kulvinskaya N. A.
Published: March 2024

Objective. To evaluate the sensitivity of methicillin-resistant Staphylococcus aureus strains to antibiotics and therapeutic and prophylactic preparations of bacteriophages.

   Materials and methods. The antibiotic sensitivity of strains of methicillin-resistant S.aureus was studied by the disco-diffusion method, the determination of the minimum inhibitory concentrations of vancomycin and linezolid by broth microdilution method, and ceftaroline by E-tests. The sensitivity of methicillin-resistant S.aureus to bacteriophage preparations was studied.

   Results. It has been established that linezolid and vancomycin are quite active drugs against methicillin-resistant S.aureus (MRSA), however, resistance to them begins to develop. MRSA resistance to fluoroquinolones and cefoxitin was the highest of all antibiotics tested; the results obtained with cefoxitin can be interpreted for other cephalosporins (except ceftaroline) and all penicillins. Only 67.9% of MRSA strains retained sensitivity to ceftaroline, but ceftaroline-resistant strains had low levels of minimal inhibitory concentration. The preparations of the bacteriophages “Sextaphage” and “Piobacteriophage Phagio” showed their lytic activity only in relation to 35.8% and 18.9% of MRSA isolates, respectively.

   Conclusion. Monitoring the development of antibiotic resistance in methicillin-resistant S.aureus is an important part of the strategy of rational antibiotic therapy for staphylococcal infections. Only taking into account the preliminary step-by-step determination of the phage sensitivity of the causative agent of the disease, bacteriophage preparations can be considered as a completely possible alternative to antibiotics for the treatment of purulent inflammatory diseases caused by MRSA.
Dynamics of morbidity and mortality from cancer in Gomel region: statistical analysis and forecast using ARIMA model up to 2030
Authors: Volchek V. S. , Sharshakova T. M. , Los’ D. M.
Published: March 2024

Objective. To analyze the time series of morbidity and mortality from breast cancer, prostate cancer, colorectal cancer and cervical cancer in Gomel region for the period from 1982 to 2022 using ARIMA method and to make a prediction up to 2030.

   Materials and methods. We analyzed morbidity and mortality data from these cancers using statistical methods, including ARIMA modeling. Data on age at diagnosis, stage of disease, percentages of cancer detected at different stages, percentages of mortality and its dynamics after diagnosis were used.

   Results. On the basis of data analysis using ARIMA model, a model for predicting the incidence of cancer in the near future was developed. According to the forecast, it should be expected that there will be an increase in the incidence of breast, prostate, cervical and colorectal cancer until 2030, a decrease in the age of patients at first detection, a change in the pattern of detection at different stages and an increase in the percentage of disease detection in preventive examinations. Mortality from these types of cancer is projected to increase, with some changes in the average age of patientsof death indicators and stage dynamics.

   Conclusion. Predicting cancer incidence and mortality rates emphasizes the need for increased screening and early diagnosis of malignant neoplasms. This can improve earlier detection of the disease and increase the effectiveness of treatment, reducing overall cancer mortality.
Gender peculiarities of cortisol, testosterone and vitamin D blood levels in athletes
Authors: Brel Yu. I. , Medvedeva G. A. , Khaustava A. S.
Published: March 2024

Objective. To assess the gender characteristics of the concentration of cortisol, testosterone and vitamin D in blood serum in athletes, and to analyze the correlations between vitamin D levels and the hormonal status of athletes.

   Materials and methods. 52 athletes (32 men and 20 women) were examined, their age was 17-23, their sports specialization was cyclic sports (kayaking) and acyclic sports (gymnastics, martial arts), and qualification – candidates for master of sports, masters of sports. Venous blood was taken in the morning on an empty stomach before training loads. Determination of total testosterone and cortisol concentration and assessment of vitamin D level by determination of its metabolite 25(OH)D (25-hydroxyvitamin D) in blood serum was performed by immunochemiluminescent method.

   Results. In male athletes with vitamin D deficiency, serum testosterone concentration and anabolic index were significantly lower (p = 0.0093 and p = 0.0015, respectively) compared to the same indices in the group of athletes with normal vitamin D content. Correlation analysis in male athletes revealed a positive correlation between serum 25(OH)D (25-hydroxyvitamin D) content and testosterone concentration (r = 0.36; p < 0.05), as well as between 25(OH)D content and anabolic index (r = 0.42; p < 0.05). The group of female athletes with vitamin D deficiency showed significantly lower serum testosterone concentration compared to athletes with normal vitamin D levels (p = 0.0112). No significant relationships were found between vitamin D levels and cortisol concentrations in both male and female athlete groups. 

   Conclusion. The study results can be the evidence of modulation effect of vitamin D on testosterone levels in male athletes, indicating the importance of controlling and correcting vitamin D content in the dynamics of the training process.
Crohn’s disease as a debut of common variable immunodeficiency
Authors: Novikova I. A. , Ramaniva A. A. , Khoduleva S. A. , Kadochkina N. G. , Prokopovich S. S.
Published: March 2024

The article presents a case of common variable immunodeficiency without clinically significant infectious syndrome with manifestation in the form of Crohn’s disease. The article emphasizes the expediency of including in the complex of examination in chronic inflammatory diseases of the gastrointestinal tract the test for assessing the level of immunoglobulins of the main classes in serum.
Clinical observation of a patient with mixed connective tissue disease in an outpatient practice
Authors: Spoda N. N. , Nikiforova O. L. , Gorbach D. S. , Lin N. V.
Published: March 2024

Systemic connective tissue diseases are a heterogeneous group of diseases with unclear etiology, the pathogenesis of which is represented by an autoimmune process, a heterogeneous clinical picture and a variable course. Classical variants of the disease that do not cause difficulties in their verification are most common in clinical practice. But some patients have signs characteristic of various connective tissue diseases. This combination of symptoms is called mixed connective tissue disease or “cross syndrome” (Overlap-syndrome). The multi-organ nature of the clinical picture of the disease presents a diagnostic difficulty for the clinician and leads to late diagnosis, ineffective therapy, and disability of the patient. The article presents a clinical case of mixed connective tissue disease in a middle-aged patient. An analysis of literary sources, clinical data, and laboratory results was carried out.
Interactions of humoral immune response indicators and parameters of systemic inflammatory response in patients with post-COVID-19 syndrome
Authors: Nikiforova O. L. , Osipkina O. V. , Galinovskaya N. V. , Voropaev E. V.
Published: March 2024

Objective. To assess the state of the systemic inflammatory response and humoral immune response in middle-aged patients came through COVID-19 infection in mild and moderate severity.

   Materials and methods. A cohort single-center study involving 83 patients came through COVID-19 infection in mild and moderate severity (women - 69.9% (58 patients), men - 30.1% (25 patients); median age 53 years [49; 56] was conducted over the period 2022-2023. All patients underwent clinical examination, evaluation of humoral response with determination of IgG and IgM antibodies to SARS-CoV-2 virus, as well as concentration of interleukins: interleukin-1β, interleukin-4, interleukin-6, interleukin-8, interleukin-10, high-sensitivity C-reactive protein, tumour necrosis factor α, transforming growth factor β1 and procalcitonin concentrations. Patients were divided into three groups: 1-3 months; 3-6 months; and 6 months to 1 year after COVID-19 infection.

   Results. Within a year the percentage of IgM-positive patients in all patient groups was about a quarter (25 %, 21 % and 25 % respectively). While remaining within the reference values for the whole group, procalcitonin and interleukin-10 levels in the selected cohort exceeded those of the test-negative cohort (p = 0.0053 and p = 0.0044, respectively), which we considered as persistent chronic compensated inflammation.

   Conclusion. A quarter of patients who came through COVID-19 infection in mild and moderate severity have persistently positive IgM levels for a year, combined with proinflammatory status according to systemic inflammatory response parameters.
4-Carboxyanilinium dihydrogen phosphate monohydrate, an organophosphate adducts of 4-amino benzoic acid: Structural, vibrational, thermal, and computational studies
Authors: Panicker Lata
Published: March 2024

4-Carboxyanilinium dihydrogen phosphate monohydrate (4-CAH2PO4·H2O), an organophosphate adduct, was synthesized and characterized by single-crystal X-ray diffraction, Fourier transform infrared (FTIR), Differential scanning calorimetry (DSC) and computational analysis performed using CrystalExplorer 21, Gaussian 09W and Multiwfn 3.7 software. The complex 4-CAH2PO4·H2O crystallized in the triclinic space group, P-1, with two molecules each of 4-carboxyanilinium (4-CA) cations, H2PO4– anions, and water, respectively, in an asymmetric unit. Crystal data for C7H12NO7P: triclinic, space group P-1, a = 8.5238(2) Å, b = 8.9068(2) Å, c = 14.4976(4) Å, α = 106.456(2)°, β = 90.195(2)°, γ = 92.811(2)°, V = 1054.13(5) Å3, Z = 4, T = 293 K, μ(Cu Kα) = 2.587 mm-1, Dcalc = 1.595 g/cm3, 18182 reflections measured (6.358° ≤ 2Θ ≤ 146.396°), 4149 unique (Rint = 0.1018, Rsigma = 0.0521) which were used in all calculations. The final R1 was 0.0584 (I > 2σ(I)) and wR2 was 0.1712 (all data). The organic layer containing 4-CA cations and the inorganic layer containing phosphate anions and water molecules in 4-CAH2PO4·H2O crystals are connected through a three-dimensional network of strong charge-assisted N–H···O and C-OH···O hydrogen bonds. The fingerprint plot of 4-CAH2PO4·H2O obtained indicated that the most prominent interaction corresponds to the short O···H contact, followed by the H···H and H···C contacts. The intermolecular interaction topology of 4-CAH2PO4·H2O has been quantitatively analyzed. The 4-CAH2PO4·H2O complex was optimized by density functional theory (DFT) with B3LYP/6-31G basis set and the theoretical IR vibrational spectra determined. The noncovalent interaction (NCI) and quantum theory of the atom in the molecule (QTAIM) analysis were done using Multiwfn 3.7 software. 4-CAH2PO4·H2O complex structure and its computational analysis are also compared with that of 4-carboxyanilinium dihydrogen phosphate (4-CAH2PO4).
Synthesis, crystal structure, and spectroscopic characterization of a new non-centrosymmetric compound, 1-(2-chloroquinolin-3-yl)-N-(4-fluorobenzyl)methanimine
Authors: Hachicha Maha , Nasri Rawia , Zid Mohamed Faouzi , Mrabet Hedi
Published: March 2024

In this work, we report the synthesis and characterization of a new condensed aromatic heterocycle (1-(2-chloroquinolin-3-yl)-N-(4-fluorobenzyl)methanimine) useful in various fields, mainly in medicinal and therapeutic chemistry, with interesting biological properties. Characterization of the title compound was carried out by 1H, 13C, 19F nuclear magnetic resonance and X-ray diffraction techniques. The crystal structure reveals that title compound crystallizes in the monoclinic system and crystal data for C17H12ClFN2: monoclinic, space group P21 (no. 4), a = 7.2253(10) Å, b = 5.7720(10) Å, c = 17.105(2) Å, β = 95.338(10)°, V = 710.26(18) Å3, Z = 2, T = 298(2) K, μ(MoKα) = 0.274 mm-1, Dcalc = 1.397 g/cm3, 5010 reflections measured (4.784° ≤ 2Θ ≤ 54.324°), 3160 unique (Rint = 0.0501, Rsigma = 0.0506) which were used in all calculations. The final R1 was 0.0339 (I > 2σ(I)) and wR2 was 0.0907 (all data). The obtained molecular structure has an antiparallel arrangement of the molecular unit leading to a one-dimensional framework.
Synthesis and structural depiction of the isomeric benzimidazole pair and its in-silico anti-SARS-CoV-2 activities
Authors: Debnath Ananya , Mahato Shreya , De Abhranil , Verma Himanshu , Silakari Om , Biswas Bhaskar
Published: March 2024

The present work presents a straightforward synthesis, spectroscopic and structural depiction, and in silico anti-SARS-CoV-2 activity of an isomeric monosubstituted benzimidazole pair, 2-(1H-benzo[d]imidazol-2-yl)-6-methoxyphenol (L1O) and 4-(1H-benzo[d]imidazol-2-yl)-2-methoxyphenol (L1P). The derivatives were synthesized by a coupling of aromatic aldehydes and o-phenylenediamine in ethanol under reflux. Different spectroscopic methods and X-ray structural analysis were employed to characterize the compounds. The crystal structure of L1O reveals that the o-vanillin substituted benzimidazole compound crystallizes in a monoclinic system and adopts a planar geometry. In silico anti-SARS-CoV-2 proficiencies of synthetic derivatives were evaluated against the main protease (Mpro) and nonstructural proteins (nsp2 and nsp7) of SARS-CoV-2. Molecular docking reveals the binding scores for the L1O-Mpro, L1O-nsp2 and L1O-nsp7 complexes as -11.31, -6.06 and -8.13 kcal/mol, respectively, while the binding scores for the L1P-Mpro, L1P-nsp2 and L1P-nsp7 complexes as -10.62, -5.09 and -6.91 kcal/mol, respectively, attributing the excellent conformational stability for both the isomeric benzimidazole derivatives.
Effect of air pollution on plant life in the city of Chittagong, Bangladesh
Authors: Jubaer Ahmed , Ali Mohammed Khorshed , Hassan Saiyed Mahmud Tanvir , Islam Md.Shahidul , Alam Muhammad Mahabub , Islam Sajia , Talukder Mohammad Zahirul Islam , Sourav Rubayat Tahrim
Published: March 2024

Bangladesh faces a serious problem with air pollution, which has a negative impact on human health and tree health. Leaf damage, slow development, and decreased photosynthetic activity are just a few of the harmful effects on trees that have been linked to high concentrations of pollutants such as particulate matter, sulfur dioxide, and nitrogen oxides. These consequences affect the aesthetic value of green spaces in addition to interfering with the functions of the ecosystem that trees offer, such as air filtration and carbon sequestration. Given the seriousness of the problem, the present study plan was implemented to evaluate the amount of pollutants such as SOx, NOx, O3, hydrocarbons, particulate matter 2.5, particulate matter 10 and suspended particulate matter in the air in several urban areas of Chittagong and to evaluate the amount of chlorophyll from the leaves of affected and without affected leaves so that it may understand how the photosynthesis process of plants is interrupted by air pollution. 2 Number Gate Circle, Akbarsha Lane Circle, Alongkar Mor Bus Stop, Barik Building Circle, BDR Field Circle, Halishahar Access Road, Artillery Center-North Halishahar, Bangladesh Forest Research Institute and CRB Circle were selected as sampling location based on their heavy traffic and crowdedness. For the analysis of chlorophyll, each plant leaves were collected in three sections such as unaffected, slightly affected, and affected for comparison. The data studied showed that the most polluted zone with particulate matter had a lower chlorophyll concentration in the surrounding tree leaves. This can indicate that particulate matter can hinder photosynthesis reactions.
Graphical Contents
Authors: Arslan Hakan
Published: March 2024

Graphical Contents
Multidimensional Intervention for Social Anxiety (MISA) program: Patient's workbook
Authors: Caballo Vicente , Salazar Isabel , Garrido Laura
Published: March 2024

This "Patient's Workbook" is aimed primarily at those who suffer from social anxiety and are looking for a therapeutic alternative that will significantly change their lives. This book is an essential part of the Multidimensional Intervention for Social Anxiety (MISA) program and is the inseparable complement to the "Therapist's Guide" for health professionals who apply this program. The "Patient's Workbook" is an eminently practical work, designed for those affected by social anxiety to learn in more detail the clinical characteristics of the problem and to follow step by step the adventure of personal change through the numerous self-monitoring (up to 59 tables), explanatory and recording figures (38), exercises (up to 121) and tasks that comprise the MISA program. Through the various activities you will practice values education, acceptance of emotions and sensations, mindfulness, detachment (defusion) from dysfunctional thoughts, acting in the opposite direction, cognitive restructuring, exposure, and social skills training. A remarkable utility of this book will be to be able to write directly in it, thus keeping a real diary of the active involvement of the interested persons. The program consists of 15 intervention sessions, in addition to assessment sessions, before and after treatment, and follow-up sessions. This "Patient Workbook" also includes all the homework assignments from the program, designed to help generalize what has been learned in the clinical sessions to real life. The MISA program incorporates many strategies to address social anxiety and the problems it causes for those who suffer from it, and we are confident that, if they complete the program, they will greatly improve not only their social life but their life in general.