bluuebunny/crossref_metadata_2025 huggingface dataset:
Network study of miRNA regulating traumatic heterotopic ossification
Authors: Lian Kun , Chen Zhiyan , Chen Leijie , Li Yongmei , Liu Luping
Published: February 2025

Objective

Objective: To identify and analyze the microRNAs that are expressed differently (DE-miRNAs) and forecast their potential roles in the pathophysiological process of traumatic heterotopic ossification (THO).

Methods

We conducted RNA sequencing on six samples of normal bone and THO tissues from the patients and conducted differential expression analysis of miRNA. The biological activities of the target genes of the differentially expressed microRNAs (DE-miRNAs) were investigated using Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses. The miRNA-mRNA network was constructed using Cytoscape software, incorporating miRNAs with varying expression levels and their corresponding target genes.

Results

In comparison to the normal control group, a total of 84 differentially expressed microRNAs (p<0.05, |log2FC|>1) were identified, with 27 microRNAs showing up-regulation and 57 microRNAs showing down-regulation. The functional enrichment analysis revealed that the target genes of the de-mirna were primarily enriched in biological processes such as the regulation of protein stability and the management of neuromuscular process balance. Additionally, a miRNA-mRNA expression regulatory network was established. The RT-qPCR analysis revealed that miR-142-3p, miR-150-5p, miR-421, miR-625-5p, miR-675-5p, and miR-940 exhibited a decrease in expression levels in THO tissues. Nevertheless, the expression levels of miR-181c-3p, miR-320c, miR-497-5p, and miR-99a-5p were increased in THO tissues.

Conclusions

Our investigation has uncovered the expression patterns and projected the potential activities of differentially expressed microRNAs (DE-miRNAs) in human THO. This research may contribute to a better understanding of the underlying mechanisms and offer new possibilities for therapeutic targets in THO.
Research on multi-condition optimization of centrifugal compressor impeller meridian profile
Authors: Yu Ning , Yu Xiaohan , Cai Zhi , Yang Xinle , Tian Liyong , Li Song
Published: February 2025

The turbocharger, a pivotal technology for energy conservation and emission reduction, offers substantial academic significance, particularly in the in-depth study of its core component: the centrifugal compressor impeller. This research aims to enhance the centrifugal compressor’s overall efficiency by optimizing its impeller meridional profile. By modifying the impeller meridional profile of a certain centrifugal compressor impeller to address the issue of discontinuous curvature, this paper aims to optimize the comprehensive average efficiency under variable speed and variable flow conditions. The optimization goal is to improve the overall average efficiency while maintaining the high pressure ratio based on the prototype scheme. The NSGA-III optimization algorithm is employed for multi-condition optimization, aiming to achieve comprehensive efficiency improvements under multiple operating speeds. The following conclusions are drawn: under multi-speed conditions, the optimized scheme exhibits comprehensive efficiency improvements over the prototype scheme, with an expanded stable operating flow range and maintained high-pressure ratio based on efficiency improvement, without sacrificing the operating flow range. Comparisons of internal flow conditions indicate that the optimized impeller features a smoother meridional passage and a reduced high-entropy region at the outlet, leading to lower entropy values. Additionally, pressure increases on both sides of the impeller blades while pressure differentials diminish, signifying enhanced internal flow conditions.
A guanidine-based coronavirus replication inhibitor which targets the nsp15 endoribonuclease and selects for interferon-susceptible mutant viruses
Authors: Van Loy Benjamin , Pujol Eugènia , Kamata Kenichi , Lee Xiao Yin , Bakirtzoglou Nikolai , Van Berwaer Ria , Vandeput Julie , Mestdagh Cato , Persoons Leentje , De Wijngaert Brent , Goovaerts Quinten , Noppen Sam , Jacquemyn Maarten , Ahmadzadeh Kourosh , Bernaerts Eline , Martín-López Juan , Escriche Celia , Vanmechelen Bert , Krasniqi Besir , Singh Abhimanyu K. , Daelemans Dirk , Maes Piet , Matthys Patrick , Dehaen Wim , Rozenski Jef , Das Kalyan , Voet Arnout , Vázquez Santiago , Naesens Lieve , Stevaert Annelies
Published: February 2025

The approval of COVID-19 vaccines and antiviral drugs has been crucial to end the global health crisis caused by SARS-CoV-2. However, to prepare for future outbreaks from drug-resistant variants and novel zoonotic coronaviruses (CoVs), additional therapeutics with a distinct antiviral mechanism are needed. Here, we report a novel guanidine-substituted diphenylurea compound that suppresses CoV replication by interfering with the uridine-specific endoribonuclease (EndoU) activity of the viral non-structural protein-15 (nsp15). This compound, designated EPB-113, exhibits strong and selective cell culture activity against human coronavirus 229E (HCoV-229E) and also suppresses the replication of SARS-CoV-2. Viruses, selected under EPB-113 pressure, carried resistance sites at or near the catalytic His250 residue of the nsp15-EndoU domain. Although the best-known function of EndoU is to avoid induction of type I interferon (IFN-I) by lowering the levels of viral dsRNA, EPB-113 was found to mainly act via an IFN-independent mechanism, situated during viral RNA synthesis. Using a combination of biophysical and enzymatic assays with the recombinant nsp15 proteins from HCoV-229E and SARS-CoV-2, we discovered that EPB-113 enhances the EndoU cleavage activity of hexameric nsp15, while reducing its thermal stability. This mechanism explains why the virus escapes EPB-113 by acquiring catalytic site mutations which impair compound binding to nsp15 and abolish the EndoU activity. Since the EPB-113-resistant mutant viruses induce high levels of IFN-I and its effectors, they proved unable to replicate in human macrophages and were readily outcompeted by the wild-type virus upon co-infection of human fibroblast cells. Our findings suggest that antiviral targeting of nsp15 can be achieved with a molecule that induces a conformational change in this protein, resulting in higher EndoU activity and impairment of viral RNA synthesis. Based on the appealing mechanism and resistance profile of EPB-113, we conclude that nsp15 is a challenging but highly relevant drug target.
HBV polymerase recruits the phosphatase PP1 to dephosphorylate HBc-Ser170 to complete encapsidation
Authors: Hsieh Chi-Ling , Chang Li-Yang , Chen Pei-Jer , Yeh Shiou-Hwei
Published: February 2025

The HBV core (HBc) protein contains an N-terminal domain (NTD) for capsid assembly and an arginine-rich C-terminal domain (CTD) for pregenomic RNA (pgRNA) encapsidation. Phosphorylation of the HBc CTD, especially at Ser162 and Ser170, is essential for nucleation with the polymerase (Pol) to initiate pgRNA encapsidation. As capsids mature, the HBc CTD undergoes dephosphorylation, suggesting the involvement of a phosphatase in the late stage of encapsidation, which remains to be determined. Using a C-S170 antibody specific for non-phosphorylated HBc-Ser170, we observed a transition from a phosphorylated to a dephosphorylated state during pgRNA packaging. The Pol-dependent dephosphorylation of HBc-Ser170 was confirmed by the substitution of one single amino acid at Val782 in the RNase H domain, which abolished the dephosphorylation of HBc-Ser170. Immunoprecipitation, mass spectrometry analyses, and the protein structural analyses showed that the recruitment of the host phosphatase PP1 is dependent on the Pol-Val782 domain. This recruitment does not require HBc but does require Pol via epsilon RNA signal, suggesting that the Pol-pgRNA complex plays a key role in PP1 recruitment. Pol-pgRNA-PP1-mediated dephosphorylation of HBc-Ser170 is essential for the completion of pgRNA encapsidation and appears to be associated with late endosomes/multivesicular bodies (MVBs). Therefore, HBV Pol may play a dual role by initially bringing pgRNA to phosphorylated HBc and recruiting PP1 for later completion of RNA packaging into the capsids. These findings not only decipher the mechanism by which Pol-mediated dephosphorylation of HBc regulates pgRNA encapsulation, but also reveal the possibility of PP1 as a potential target for antiviral development.
Digital Entrepreneurship in Brazil: Insights From The Digital Platform Economy Index Analysis
Authors: Kusumaningrum Sita Dewi , Wibisono Eristian
Published: February 2025

Digital Entrepreneurship Ecosystem (DEE) integrates the concepts of Digital Ecosystem (DE) and Entrepreneurship Ecosystem (EE). Developed over the last decade, research and application of DEE in developing countries remains limited. In this paper, we use a DEE in the form of the Digital Platform Economy (DPE) index, which measures the state of DEE in 116 countries, taking Brazil as a case study and comparing it with two benchmark countries (Uruguay and Argentina) that are members of the MERCOSUR group of economies. Through a five-step structured analysis, we first examine the general condition of Brazil's DEE in terms of development and then analyze the derived components of the DPE index to find the strengths and weaknesses of Brazil's DEE compared to the two benchmark countries. The results show a healthy balance between DE and EE in Brazil. However, through further analysis using the Penalty for Bottleneck (PFB) method, we recommend four main pillars of DEE, namely digital literacy, digital openness, digital adoption, and digital access, to maintain the balance between DE and EE and improve Brazil's DEE. Our results contribute to the development of DEE literature and promote DEE evaluation methods as a way to recommend DEE development in developing countries.

 
Keywords: Digital entrepreneurship, DPE index, digital ecosystem, entrepreneurial ecosystem.
Impact of National Quality Infrastructure Development on Export Performance in Sri Lanka
Authors: Bandara Willora Mudiyanselage Dulanjali Upamalika , Intarakumnerd Patarapong
Published: February 2025

This study examines the impact of National Quality Infrastructure (NQI) development on Sri Lanka’s export performance from the perspectives of Sri Lankan exporters, addressing a gap in the existing literature. Using a mixed-methods approach, this research integrates secondary data analysis, surveys of export-oriented businesses, and sector-specific case studies. Findings reveal a positive correlation between Quality Infrastructure for Sustainable Development (QI4SD) and export performance in countries such as China, Japan, and South Korea; however, moderate outcomes in Singapore and India suggest additional influencing factors. Survey data indicate that exporters employ Metrology, Standards, Testing, and Quality (MSTQ) frameworks to enhance productivity and product quality. Sector-specific case studies highlight distinct priorities, with edible goods exporters focusing on hygiene and safety standards, and non-edible goods exporters prioritizing efficiency and consistency. Despite MSTQ adoption, exporters encounter persistent challenges such as financial constraints and trade barriers. The study concludes with policy recommendations to improve knowledge dissemination, expand financial support, address import restrictions through collaborative policies, and enhance participation in Free Trade Agreements. These measures are crucial for fostering sustainable growth in Sri Lanka’s export sector.
From Education to Family Networks: Analyzing Demographic and Socio-Economic Drivers of Migration Intentions in Bangladesh Under the NELM Framework
Authors: Shawon Talukdar  , Habiba Umme
Published: February 2025

This study examines the impact of demographic and socioeconomic factors on migration intentions in Bangladesh within the New Economic Theory of Migration (NELM) framework. Using logistic regression and cluster analysis on convenience survey data, findings show that higher education (OR = 1.45, p < 0.01) and higher income (OR = 1.20, p < 0.05) significantly increase migration intentions. Having family members who migrated also elevates intentions (OR = 1.60, p < 0.01). Interaction effects reveal distinct patterns among younger-educated individuals (p < 0.05). Cluster analysis identifies younger, lower-income, and educated individuals as most likely to migrate, highlighting NELM’s policy relevance.
Multi-criteria analysis of optimal educational teacher allocation system
Authors: Gavriil Konstantinos , Giannikos Ioannis
Published: February 2025

This paper presents a model for automatically selecting and allocating secondary education teachers to schools while considering various factors such as the diversity of sections and lessons, school distances, teacher specializations, teaching workloads, and other constraints. This poses a complex challenge that educational authorities in prefectures must address. Our proposed model is inherently multi-objective, as it encompasses a range of financial and pedagogical objectives. By employing this model, decision-makers can explore the competition between these objectives and the necessary trade-offs required to enhance performance in specific areas. To illustrate the model's practical applicability, we conducted a case study focusing on the Prefecture of Ilia in Western Greece.
SMART SYSTEM UNTUK PEMANTAUAN DAN OPTIMASI KINERJA PEMBANGKIT LISTRIK TENAGA SURYA
Authors: Taneza Erlan , Firdaus Firdaus
Published: February 2025

Pembangkit Listrik Tenaga Surya (PLTS) menjadi salah satu solusi utama dalam pemanfaatan energi terbarukan. Namun, tantangan dalam hal pemantauan, perawatan, dan optimasi kinerja PLTS masih menjadi isu utama yang perlu diatasi. Artikel ini mengeksplorasi peran smart system berbasis Internet of Things (IoT), kecerdasan buatan (AI), dan machine learning (ML) dalam meningkatkan efisiensi operasional PLTS. Melalui systematic literature review, penelitian ini mengidentifikasi berbagai metode dan teknologi yang telah digunakan untuk pemantauan, deteksi, prediksi, dan optimasi kinerja PLTS. Hasil menunjukkan bahwa teknologi smart system mampu meningkatkan efisiensi pemantauan hingga 95%, prediksi kerusakan hingga 110,8%, dan output energi hingga 130% dibanding dengan pendekatan manual-konvensional. Penggunaan teknologi ini memberikan solusi efektif dalam menghadapi tantangan operasional PLTS dan meningkatkan kinerja jangka panjangnya. Temuan ini menawarkan panduan praktis dan rekomendasi untuk pengembangan lebih lanjut dalam pengelolaan PLTS berbasis teknologi cerdas.
Production of virus-free quality planting material in banana (Musa spp.) variety CO 3 (ABB) through meristem culture
Authors: Thanuja K , Arulmozhiyan R , Saraswathi M S , Selvarajan R , Jegadeeswari V , Babu V R
Published: February 2025

The rapid spread of pest and disease infestations significantly affects agricultural productivity and food security. Diseases caused by fungi, bacteria, viruses and other pathogens can severely impact plant health, leading to substantial crop losses. Some crop species, like banana (Musa spp.), transmit viral diseases mostly through vegetative propagules but very rarely through seeds. To address this issue, meristem culture was employed in the present study on the banana variety CO 3 (ABB) to produce virus-free plantlets. Meristem tips, ranging from 20-30 mm in size, were established on fullstrength MS medium supplemented with vitamins, ascorbic acid, myoinositol,2 mg/L BAP and 0.5 mg/L IAA during the initiation phase. MS medium with 3 mg/L BAP and 0.5 mg/L IAA was optimal for multiple shoot formation, producing an average of 8.5 shoots per explant in 52.5 days. Regarding growth parameters, approximately 3.7 leaves per explant were observed, with an average leaf length of 4.56 cm and an average leaf width of 1.89 cm after the fifth subculture and before the rooting stage. The meristem tips (20-30 mm) of the CO 3 (ABB) variety produced approximately 92.5% virus-free plantlets with a survival rate of 86.5%. The derived plantlets were successfully hardened.
Poza agon. Dekolonizacje tradycji feministycznej w projektach lekturowych Arlety Galant i Agnieszki Gajewskiej
Authors: Świerkosz Monika
Published: February 2025

Artykuł jest próbą przyjrzenia się zmianom w sposobie uprawiania feministycznej krytyki literackiej w Polsce po roku 2005 w kontekście pojęć takich jak polityka tożsamości, polityka umiejscowienia, kobieca tradycja czy kobieca wspólnota czytelnicza. Na przykładzie dwóch projektów krytycznofeministycznych: Arlety Galant i Agnieszki Gajewskiej, autorka szkicu wskazuje na istotność kategorii „różnicy” (nie tylko płciowej) rozumianej w sposób nieesencjalistyczny, nomadyczny i nieantagonistyczny. Mimo wyraźnej rewizji narzędzi lekturowych wypracowanych na gruncie drugofalowych „studiów kobiecych” obie krytyczki pozostają wewnątrz feministycznej wspólnoty czytelniczej, poszukując jednak innych niż agonistyczne sposobów rozczytywania tego, co tożsame, i tego, co różne.
Figura filozoficznego autorytetu w polskiej postmodernistycznej krytyce literatury – na przykładzie Martina Heideggera
Authors: Orska Joanna
Published: February 2025

Artykuł przedstawia okoliczności lektury pism Heideggera w Polsce w latach 70. XX wieku oraz w okresie transformacji ustrojowej. Tak jak we Francji, także i w Polsce niemiecki reformator fenomenologii okazał się zasadniczym punktem odniesienia dla tekstocentrycznych metodologii poststrukturalizmu. Artykuł pokazuje, w jaki sposób krytycznoliterackie ujęcie tez filozoficznych autora Budować, mieszkać, myśleć w połączeniu z mocną inspiracją pismami Michela Foucaulta ukształtowały charakter krytyki jednej z bardziej oryginalnych postaci polskiej debaty o literaturze okresu transformacji ustrojowej – Tadeusza Komendanta. Specyficzny, filozoficzno-literacki styl autora Władz dyskursu oraz Upadłego czasu wraz z poetyckimi definicjami, za pomocą których usiłował uchwycić reguły poststrukturalizmu na polski użytek, wywarły, jak próbuję dowodzić, zasadniczy wpływ na dyskurs potransformacyjnej krytyki poezji.
Genetics and diagnostics of inherited retinal diseases in the era of whole genome sequencing
Authors: Stöhr Heidi , Weber Bernhard H. F.
Published: February 2025

Inherited retinal diseases are clinically and genetically highly heterogeneous conditions with many phenotypic overlaps, syndromic presentations and atypical manifestations. This article is a narrative review that offers an overview of the technical advancements improving the accuracy and efficiency of molecular genetic diagnostics for hereditary disorders in clinical practice. It focuses particularly on the integration of whole genome sequencing (WGS) into routine diagnostics, critically evaluating its potential by discussing recent data from cohort studies conducted worldwide.
Ultrasensitive metasurface sensor based on quasi-bound states in the continuum
Authors: Li Ning , Chen He , Zhao Yunxia , Wang Yongtian , Su Zhaoxian , Liu Yin , Huang Lingling
Published: February 2025

The quasi-bound state in the continuum (quasi-BIC) of dielectric metasurface provides a crucial platform for sensing, because its almost infinite Q-factor can greatly enhance the interactions between light waves and the analytes. In this work, we proposed an ultrasensitive all-dielectric metasurface sensor composed of periodic rectangular amorphous silicon pillars on a quartz substrate. By breaking symmetry of two pillars in unit cell, high Q quasi-BIC in the continuous near-infrared band can be excited. The magnetic toroidal dipole (MTD) is demonstrated to play a dominating role in the resonant modes by analyzing near-field distribution and multipole decomposition. The asymmetry degree has a significant impact on sensing performance of the proposed metasurface sensor, whose underlying physical mechanisms is analyzed by perturbation theory. The transmission spectrum and sensing performance of the fabricated metasurface sensor were measured. The experimental results show our designed metasurface sensor not only achieve a high sensitivity of 413/RIU, but also shows a high figure of merit (FOM) of 66 RIU−1. This work provides excellent prospects for the excitation of strong MTD resonance quasi-BIC in sensing applications.
Discordant risk factors between pancreatic neuroendocrine neoplasms and pancreatic ductal adenocarcinoma
Authors: Chandra Shruti , Halfdanarson Thorvardur R , Carlson Erin E. , Rabe Kari G , Mahipal Amit , Majumder Shounak , Bamlet William R , Horibe Masayasu , Tella Sri Harsha , Shariq Omair , Carr Ryan , Cleary Sean P. , Oberg Ann L. , Antwi Samuel O.
Published: February 2025

Pancreatic neuroendocrine neoplasm (panNEN) is a rare malignancy and the second most common type of pancreatic cancer, after pancreatic ductal adenocarcinoma (PDAC), but its etiology is poorly understood. We investigated whether the risk factors of panNEN are concordant with those known for PDAC. We performed the largest case-control study to date on panNENs comprising 927 sporadic nonfunctional panNEN cases and 1807 frequency-matched controls using data from the Mayo Clinic Biospecimen Resource for Pancreas Research. We assessed associations for obesity, first-degree family history of pancreatic cancer, cigarette smoking, overall type II diabetes mellitus (T2DM), new-onset T2DM (<1 year before panNEN diagnosis), longstanding T2DM (≥5 years), alcohol intake, and aspirin use. Multivariable logistic regression was used to calculate odds ratios and 95% confidence intervals (CIs). Our results show that overall T2DM (OR=1.71, 95% CI: 1.37-2.14) and new-onset T2DM (OR=2.65, 95% CI: 1.92-3.69) are associated with higher odds of panNEN, but not longstanding T2DM (OR=1.29, 95% CI: 0.94-1.75). A non-significant elevated odds of panNEN was observed among participants with a positive family history of pancreatic cancer (OR=1.44, 95% CI: 0.96-2.14). Alcohol use was inversely related to panNEN (OR=0.52, 95% CI: 0.42-0.66, ever-vs-never). No association was observed for smoking, obesity, or aspirin use. These findings indicate that overall T2DM and new-onset T2DM are associated with higher odds of panNEN. Unlike PDAC, alcohol use was inversely related to panNEN, and we found no associations for cigarette smoking, obesity, or aspirin use. These results indicate differences in the risk factor profiles of panNEN and PDAC.
Sistema recomendador de recursos académicos para estudiantes universitarios
Authors: Silva Gomez Giancarlo Ricardo , Sifuentes Marcelo Roberto
Published: February 2025

The pandemic generated a greater importance to online education. Hundreds of students sign up for online courses offered by universities or other institutions. However, due to the large number of options this poses a problem when choosing the course, in addition in the country there is an imbalance between supply and demand for labor. Companies are requesting professionals with more technological skills; therefore, the objective of the system is to improve the process of academic orientation for university students: Recommend courses based on their searches. The system was developed according to the methodology of the software development cycle consisting of 4 stages: Analysis, Design, Development and Testing, with an estimated duration of 2 months, where the datasets used were 3 of the Kaggle platform based on e-learning platforms as Udemy. To validate, a survey was carried out on 20 students at the last cycle of the Faculty of Systems Engineering of the UNMSM because these students are more qualified in the career and have more definite doubts about the competences they wish to acquire. The results showed that at least 75 per cent of respondents found the system useful; helps them in their academic orientation and saves them considerable search time by meeting the research objective at a considerable level in most respondents.
La Inteligencia artificial y sus implicancias en el Control Interno y la Gestión de los Inventarios
Authors: Cortez-Vásquez Augusto , García Conde Ronald Ulises
Published: February 2025

La Inteligencia Artificial (IA) está transformando significativamente el control interno y la gestión de inventarios en las organizaciones modernas. El control interno y la gestión de los inventarios, tiene como fin establecer la asociación que hay entre el control interno que efectúan las compañías y la gestión de sus inventarios para lograr administrar de manera eficiente y eficaz sus bienes o recursos, maximizando sus ganancias. El análisis permitió proponer estrategias que usen la Inteligencia artificial para mejorar su situación tanto económica como financiera. Al finalizar se consignan las conclusiones y recomendaciones resultado de esta indagación.
Cambios tecnológicos y el capital humano
Authors: Estela Estela Adán Humberto , Villacorta Huapaya José Antonio
Published: February 2025

En el siglo XXI, las tendencias innovadoras y el acelerado avance tecnológico han motivado a las empresas a implementar mejoras digitales. No obstante, pocas organizaciones logran integrar estos cambios con la gestión del capital humano, pese a que la tecnología afecta todos los niveles de la estructura organizacional. Este ensayo examina cómo la globalización y el entorno digital han transformado las áreas de recursos humanos, alterando tanto las expectativas de los colaboradores como el rol de los directivos. Se concluye que es fundamental reconocer el valor intangible del capital humano en la adaptación organizacional y que los líderes deben fortalecer las habilidades y competencias de sus equipos para afrontar un entorno digital en constante evolución.
La redacción académica y las competencias comunicativas en la escritura de los estudiantes universitarios
Authors: Roldán Rodríguez Erika Aurora
Published: February 2025

El tema del artículo de investigación a presentar tiene por título La redacción académica y las competencias comunicativas en la escritura de los estudiantes universitarios. Para lograr el propósito se revisó diversos artículos aplicándose el criterio narrativo, esta incluye un conjunto de investigaciones realizadas sobre la escritura académica en los estudiantes, abordando no solo los aspectos técnicos de la redacción, sino también las experiencias individuales de los estudiantes en su proceso de aprendizaje. Se trata de identificar las dificultades significativas de los estudiantes de pregrado en el proceso de redacción de documentos académicos indispensables en el trabajo universitario, así como el nivel de logro en las competencias comunicativas de la escritura. Se llegó a concluir, en la redacción es necesario seguir una estrategia o pauta que desarrolle y consolide la práctica de la redacción en los estudiantes universitarios. Esta incluye la preparación del estudiante en cuanto a las tipologías textuales, aplicación de estrategias para desarrollar el discurso escrito y la aplicación de los procesos de redacción.
The Fibularis Quartus Muscle: A Cadaveric Case Report with Historical, Embryological, Molecular and Clinical Considerations
Authors: Borthakur Dibakar , Kumar Rajesh , G R Namaschivayam , Ansari Mohammed Ahmed , Singh Seema
Published: February 2025

Introduction: The fibularis quartus (FQ) or peroneus quartus (PQ) is a supernumerary muscle occasionally seen in the lateral compartment of the human leg. It is a weak evertor and has a role in pronation and lateral stabilization of the foot. FQ arises from the fibularis brevis (FB) in most instances and distally gets attached to the lateral aspect of the base of the fifth metatarsal or the cuboid or the calcaneus bone. The muscle has been implicated in a variety of clinical problems ranging from ankle pain to subluxation and tear of peroneal tendons. We report here a rare bitendinous variant of FQ which might provide new insight to clinical problems related to the presence of this muscle and its possible utility as an autograft in reconstruction.Methods: Institutional guidelines for use of human cadaver were followed. Routine dissection was performed on a 71-year-old male donated cadaver in both the lower limbs. Gross anatomical features were meticulously noted, photographed and measurements were recorded with digital Vernier callipers.Results: A bitendinous muscle was observed in the lateral compartment of the left leg and identified as FQ. The FQ was proximally attached to the FB and adjacent distal third of the fibula, which then formed a flat fusiform muscle belly and eventually terminated through a rounded tendon via its attachment to the peroneal trochlea of the calcaneus. The dimensions of the proximal tendon, muscle belly and the distal tendon were 4.2 cm x 0.7 cm, 5.6 cm x 1.9 cm and 2.6 cm x 0.3 cm, respectively.Conclusions: Clinicians should be aware about all possible variants of the supernumerary FQ muscle considering its role in several lateral ankle pathologies. FQ can prove as an excellent autograft for peroneal tendon tear and can be utilized for strengthening weakened peroneal tendons.
El rompecabezas familiar: fragmentación y repetición en Quiénes somos ahora, de Katya Adaui
Authors: Campaña Fimbres Jesús Adalberto
Published: February 2025

La obra narrativa de Katya Adaui (1977) posee varios aspectos en común, tales como la fragmentación formal y la temática en sintonía con las relaciones familiares complejas. Quiénes somos ahora (2022), su novela más reciente, no es la excepción a las tendencias estéticas de la autora peruana. La escritora despliega una construcción sumamente interesante que se cimenta en la hibridación mediante la instrumentalización constante de dos recursos principales: la fragmentación y la repetición que reorienta repetidamente las temáticas de lo familiar con un lenguaje cercano a la poesía. Este artículo pretende indagar en las implicaciones de la fragmentación y de la repetición, cuya utilización representa de maneras diferentes la difícil relación del personaje principal con su madre. Se analizan escenas con énfasis en los recursos que se disponen en la narración, cuya preocupación por las formas supone un pilar dentro del tejido narrativo, además de que reconstruyen una relación fracturada. Dicha reconstrucción reúne los escombros que quedan entre madre e hija con la que carga la narradora y el personaje principal de Quiénes somos ahora.
El regreso del no-muerto: vampiros vegetales, plantas fantásticas, monstrificaciones botánicas en “La orquídea” de León Fernández Guardia y “Orquídea” de Andrés F. Wassington
Authors: Huertas Arredondo Kimberly
Published: February 2025

En este artículo analizamos el vampirismo vegetal en “La orquídea” (1907) del escritor costarricense León Fernández Guardia y “Orquídea” (2006) del argentino Andrés Federico Wassington, a través de herramientas teórico-metodológicas provenientes de la literatura comparada (tematología), la botánica, plant-horror y Ecogothic. Esta perspectiva crítica nos permite sostener que dichos relatos son, quizás, los primeros textos del fantástico vegetal, en la literatura latinoamericana, interesados en reproducir, de manera explícita y durante el siglo XX y XXI, la figura del vampiro, a partir de la flora orquideológica. Las textualidades seleccionadas aportan una renovación de la especificidad del discurso de lo fantástico, en tanto ofrecen una mirada novedosa mediante la inserción de nuevos códigos que reviven y resignifican a la planta monstruosa moderna y,  de paso, al monstruo vampiro manifestado en la tradición vampírica gótico-fantástica europea, precisamente con la tropicalización del sentimiento o efecto de lo fantástico (i.e., la monstruosidad del personaje, lo grotesco y el cuerpo abyecto) y la incorporación de vampiros vegetales
Historia, tipología y funcionalidad de las narrativas biográficas antiguas: un examen a la luz del caso euripideo y el exemplum socrático
Authors: Alfonzo Bruno D.
Published: February 2025

El estudio de la biografía antigua ha experimentado un interés creciente en décadas recienteslas últimas décadas,consolidándose como un área de investigación autónoma. Este artículo examina sus metodologías, destacando trabajos quedesde el siglo XX han explorado la literatura biográfica desde una perspectiva histórico-cronológica, para luego orientar suabordaje hacia una indagación tipológica. El artículo propone un estudio aplicado a un caso particular —el del dramaturgogriego Eurípides—, cuyo objeto es discutir los límites de la concepción tipológica habitual sobre la literatura biográficaseñalando una tercera vía de análisis (la funcional), considerada aquí una síntesis superadora de las anteriores, cuyosbeneficios hermenéuticos son puestos de manifiesto en el examen propuesto. En tal sentido, se postula una interpretaciónsobre el relato acerca de la muerte de Eurípides a partir de su relación con el proceso que llevó a la muerte a Sócrates.
Capillary electrophoresis and high-performance liquid chromatography methods for simultaneous determination of rufinamide, lamotrigine, and zonisamide in pharmaceutical formulations
Authors: Çeçen Selen Duygu , Dal Poçan Arın Gül
Published: February 2025

In this study, a simple, rapid, and sensitive capillary electrophoresis (CE) method was developed that allows simultaneous analysis of zonisamide (ZNS), rufinamide (RFN), and lamotrigine (LMT) in pharmaceutical preparations. This study introduces the first application of CE for the simultaneous determination of ZNS, RFN, and LMT in pharmaceutical dosage forms. For the comparison a High-Performance Liquid Chromatography (HPLC) method was developed. In CE method, detection was achieved using a photodiode array detector (DAD) at a wavelength of 210 nm. A capillary with an internal diameter of 75 µm and an effective length of 40 cm was used for separation. The optimum conditions were achieved using 35 mM SDS, 6 mM borate, 10 mM phosphate buffer (pH 9.00) containing 5% isopropyl alcohol (IPA), and applying a potential of 15 kV. Under these conditions, the migration times of ZNS, RFN and LMT were observed to be 5.99 min, 6.77 min and 8.46 min, respectively. In HPLC method, detection was achieved using a photodiode array detector at a wavelength of 210 nm. A C18 column (4.6 × 100.0 mm, 3.5 µm i.d.) was used for separation, with a mobile phase consisting of acetonitrile and pH 4.0 50 mM phosphate buffer (18:82, v/v) at a flow rate of 1.0 mL min−1. In this method, the retention times of ZNS, RFN and LMT were observed to be 6.41 min, 7.29 min and 4.95 min, respectively. The validity of the developed methods was examined through parameters such as linearity, precision, accuracy, sensitivity, stability, and robustness. In CE method, the limit of detection (LOD) values for ZNS, RFN and LMT were calculated as 0.035 μg mL−1, 0.016 μg mL−1 and 0.007 μg mL−1, respectively. For HPLC method, the LOD values were determined as 0.003 μg mL−1, 0.002 μg mL−1 for RFN and 0.001 μg mL−1 for LMT. Both developed methods were successfully applied to pharmaceutical dosage forms and shown to be compliant with United States Pharmacopeia (USP 47 - NF 42). In conclusion, both methods developed in our study yielded comparable results in terms of robustness and analysis time. HPLC demonstrated higher sensitivity compared to CE and is preferred for analyses at very low concentrations, while CE is ideal for green chemistry applications due to its minimal solvent and sample consumption.
Implications of behavioural economics for public regulation: An experimental study among officials of regulatory bodies in Poland
Authors: Szkudlarek Piotr
Published: February 2025

Aim: Identification and determination of the importance of behavioural factors in public regulation. The study also delved into whether officials working in public regulatory bodies exhibit behavioural patterns similar to those of non-officials when making regulatory decisions. Methodology: The author used the results from experimental studies conducted among officials from regulatory bodies in Poland, specifically the Office of Electronic Communications (OEC, n = 107) and the Energy Regulatory Office (ERO, n = 157). A control group comprised non-officials (Non-officials, n = 102). The research was conducted during the transition between 2022 and 2023. Results: The findings revealed that officials in public regulatory bodies (regulators) overseeing network sectors in Poland are not free from behavioural influences. These include the certainty effect – leading to risk aversion (positive prospect), loss avoidance effect – causing risk-seeking behaviour (negative prospect) and the reflection effect in line with prospect theory. Additionally, they demonstrated the risk aversion effect stemming from the tendency to overestimate losses and underestimate gains, uncertainty effect, status quo effect, anchoring heuristic – the effect of asymmetric domination and the better-than-average effect, calibration effect and overconfidence effect, however, the prevalence of these effects varied. Furthermore, statistically significant differences in the occurrence of these behavioural effects were observed between officials of various regulatory bodies and the Non-experts group (78.6% of cases), which were more pronounced than the differences between the regulatory bodies themselves (21.4% of cases). Implications and recommendations: The research results underline the necessity of augmenting the conventional approach to regulation with an understanding of the behavioural factors that influence regulatory decision-making. Further research and the replication of the article’s findings are necessary, primarily due to the limitations of the research results. The experiments provided an opportunity to test the behavioural effects but they did not explore their relationship with the personality traits of the subjects. This aspect will be the focus of analysis in the forthcoming article. Additionally, future experiments may uncover other behavioural effects. Originality/value: The conclusions presented in this article contribute a unique perspective to the discourse on public regulation, drawing from empirical research results. This presents findings from a study involving officials from two distinct regulatory bodies. The novelty of research into the behavioural determinants of decisions made by officials in regulatory bodies expands the realm of regulatory research. This could potentially open new avenues for resolving regulatory dilemmas.
Komodifikasi Agama Halal Tourism dalam Perspektif Dakwah
Authors: Trifita Amjad , Ar’rahmah Fat’hiyah Khasanah
Published: February 2025

Halal tourism merupakan sebuah konsep pariwisata halal yang menjadi trend saat ini. Konsep wisata halal merupakan pariwisata yang menerapkan standar Islam dalam prakteknya. Tujuan tulisan ini adalah untuk mengatahui komodifikasi agama halal tourism dalam tinjauan dakwah. Kajian ini menggunakan metode kualitatif dengan pendekatan studi pustaka. Meskipun menimbulkan pro kontra dalam realitasnya, komodifikasi agama dalam halal tourism dapat dipandang secara positif karena komodifikasi dalam wisata halal tidak menurunkan nilai atau merusak agama. Wisata halal yang mengamalkan prinsip-prinsip Islam dapat menjadi sebuah terobosan baru dalam syiar dakwah Islam dan wisatawan dapat mengenal nilai-nilai Islam dari konsep tersebut. Penelitian ini melihat proses dakwah yang terjadi pada halal tourism sehingga memiliki daya pikat sebagai objek wisata berbasis islam. Ditemukan bahwa terdapat komodifikasi halal dalam konsep halal tourism dan pesan dakwah aqidah, syari’ah, mu’amalah dan akhlak yang terkandung dalam konsep tersebut.
Strategi Dakwah Tarekat Qadiriyah wa Naqsabandiyah di Desa Bluto Kec. Bluto Kab. Sumenep
Authors: Krisdiantoro  , Tabaika Mohammad A’lan
Published: February 2025

The advancement of world civilization has brought society into the era of modernity, which forms a society that tends to be materialistic and puts aside the spiritual side. Tarekat Qodiriyah wa Naqsabandiyah is a tarekat group that is consistent with the spiritual side of humans. This research aims to find out the Qodiriyah wa Naqsabandiyah tarekat's da'wah strategy. This research uses a phenomenological approach with a qualitative research type. Data collection techniques include interviews and observations. The da'wah uses a sentimental strategy, which focuses on the inner feelings of its da'wah partners through sharing, discussion. The strategies applied in preaching are individual approaches and collective approaches. Individual da'wah is carried out by providing individual spiritual guidance. This spiritual guidance is intended so that an individual always taqarrub to Allah Subhanahu Wa Ta'ala. While collective da'wah is aimed at a group of people, in this case, a group of people can be followers of Tarekat Qadiriyah wa Naqsabandiyah or people who have not become members of the order.
Lansia Menyikapi Misinformasi
Authors: Rohmah Nurliya Ni'matul
Published: February 2025

Peningkatan populasi penduduk Lansia di Indonesia, terutama di Provinsi Nusa Tenggara Barat (NTB), telah menciptakan dampak kompleks, termasuk dalam konteks teknologi digital. Lansia, sebagai kelompok yang rentan terhadap terpengaruh penyebaran misinformasi, khususnya selama Pemilu 2024. Dengan pertumbuhan akses lansia terhadap internet, kekurangan literasi digital dan pemahaman politik yang kurang dapat meningkatkan risiko penyebaran informasi palsu. Merespons fenomena tersebut, program literasi digital terfokus pada generasi muda, meninggalkan lansia terabaikan. Lansia, sebagai digital immigrant, sering menjadi korban penyalahgunaan perangkat digital dan kurangnya perlindungan terhadap privasi online. Penelitian menunjukkan bahwa mayoritas pelaku penyebar hoaks berusia di atas 45 tahun, juga berarti bahwa Lansia di NTB memiliki tingkat literasi digital rendah, meningkatkan rentan mereka terhadap penyebaran misinformasi. This study is kualitatif dengan menggunakan metode  study kasus pada peserta pelatihan Akademi Digital Lansia dan dianalisis melalui pendekatan Interaction-Adaptation Theory. Sedangkan  dalam pelatihan Akademi Digital Lansia menggunakan metode KAP (Komunikasi Antar Personal). Penelitian ini bertujuan memberikan kontribusi pada pengembangan strategi melindungi lansia dari dampak negatif misinformasi selama Pemilu 2024 di NTB melalui program-program yang memberdayakan lansia melalui workshop literasi digital berbasis riset. Temuan dalam study ini adalah bahwa Program Akademi Digital Lansia  sebagai strategi yang efektif dalam menyikapi misinformasi di kalangan Lansia yaitu telah memberikan pengetahuan, tetapi juga menciptakan pengalaman berkomunikasi yang positif, menunjukkan efek kognitif, afektif, dan konatif.
Analisis Semiotika Kehidupan Jurnalis dalam Drama Korea HUSH
Authors: Ellyda Retpitasari  , Nurul Fadilah  , Risky Maulana
Published: February 2025

This journal is an analysis of semiotics that focuses on the life of an idealistic senior journalist in the Korean drama HUSH. Through a semiotic approach, this journal reveals how the signs and symbols in the drama influence the main character and play a significant role in the plot's development. Semiotic analysis Roland Barthes is used to understand the meaning conveyed by the signs that appear in this drama. The journal author investigates how visual signs, such as facial expressions, body language, and the characters' attire, are employed to depict emotions, personalities, and character transformations. Furthermore, the author examines the use of symbols in the background, objects, and scene setups, which add a narrative dimension to the story. In this journal, the main focus is on the central character, Lee Ji-soo, a senior journalist with a strong sense of idealism. The author explains how the signs surrounding Ji-soo, such as the events she experiences and interactions with other characters, influence her transformation into a more experienced and mature journalist. Additionally, the journal highlights the role of internal conflicts faced by Ji-soo in carrying out her profession. The author discusses how the signs and symbols that emerge in the drama reflect the moral and ethical dilemmas Ji-soo encounters in reporting news and their impact on her integrity as an idealistic journalist. Drama Hush provides a strong depiction of journalistic ethics and provides an understanding of the complexity of the world of journalism in South Korea, in the perspective of the Qur'an and Hadith in viewing the film Hush emphasizes journalistic ethics, especially honesty in accordance with the Qur'an al-Ahzab verse 70 Prophetic Hadith narrated by Abdullah Bin Mas'ud from Hadith History Muslim.
Nilai Persahabatan Sebagai Pesan Dakwah
Authors: Nisak Lailatul Khoirun , Nurdin Ali
Published: February 2025

Film merupakan media yang efektif untuk merefleksikan nilai-nilai sosial, termasuk persahabatan, melalui narasi visual dan verbal. Penelitian ini menyoroti bagaimana nilai persahabatan direpresentasikan dalam film Hangout karya Raditya Dika, yang memadukan genre komedi dan thriller. Penelitian ini bertujuan untuk menganalisis simbol-simbol dan interaksi antar karakter yang mencerminkan nilai-nilai persahabatan sebagai pesan dakwah. Penelitian ini menggunakan pendekatan semiotika Roland Barthes untuk menganalisis representasi nilai persahabatan dalam film Hangout karya Raditya Dika. Analisis dilakukan pada adegan-adegan yang menunjukkan hubungan persahabatan, dengan fokus pada makna denotatif, konotatif, dan mitos. Hasil penelitian menunjukkan bahwa film Hangout karya Raditya Dika mencerminkan nilai persahabatan sebagai pesan dakwah melalui simbol dan interaksi antar karakter. Pada tingkat denotatif, persahabatan tergambar melalui tindakan nyata seperti pengorbanan Titi Kamal yang mencerminkan nilai itsar (mendahulukan orang lain) dan dialog kejujuran Radit kepada Soleh yang menekankan pentingnya menjaga amanah. Pada tingkat konotatif, simbol kehilangan seperti foto yang dicoret merah mengingatkan pentingnya menghargai sesama dan mempersiapkan diri untuk akhirat (dzikrul maut), sedangkan dukungan emosional memperkuat ukhuwah Islamiyah. Pada tingkat mitos, nilai budaya seperti gotong royong dan kebersamaan selaras dengan ajaran Islam tentang ta’awun. Pesan dakwah yang tersirat adalah bahwa persahabatan sejati melibatkan kejujuran, pengorbanan, dan solidaritas, yang memperkuat hubungan manusia sekaligus mendekatkan diri kepada Allah SWT.
Anti-corruption measures in German local government using the example of the city of Bremen
Authors:   State Higher Vocational School in Włocławek, Zariczny Piotr
Published: February 2025

Germany, as one of the leading European countries, is also engaged in comprehensive anti-corruption efforts. It is worth taking a look at anti-corruption practices in German local government, and particularly focusing on the case of the city of Bremen. German local government is characterized by a high degree of autonomy, which gives local authorities a great deal of freedom in managing their affairs. However, with this autonomy comes challenges in preventing and combating corruption. The city of Bremen, as one of the 16 states of the Federal Republic of Germany, represents a compelling research case because of its approach to fighting corruption. Understood as a free Hanseatic city (Freie Hansestadt Bremen) and a federal state (Bundesland), the city of Bremen exhibits advanced anti-corruption structures. Central to this is the Anti-Corruption Commission, which focuses on monitoring and combating all forms of corruption at the local level. This commission works in close cooperation with police authorities and internal control bodies. Bremen is taking proactive measures to prevent corruption. One of the key instruments is training programs aimed at local government employees, which cover public service ethics, accountability, and rules of conduct. In addition, there is a clear and transparent code of conduct for local government employees that specifies expected ethical standards. The City of Bremen recognizes the important role of civil society in combating corruption. These efforts focus on working with NGOs, conducting educational campaigns, and establishing communication channels for citizens to report cases of corruption. Public trust in local government institutions is therefore crucial, which confirms the introduced effectiveness of the anti-corruption measures. The case of the city of Bremen shows that the fight against corruption in German local government requires an integrated approach, combining proactive measures, cooperation with civil society and monitoring structures.