bluuebunny/crossref_metadata_2025 huggingface dataset:
Potential Benefits of Boswellia sacra Resin on Immunity, Metabolic Status, Udder and Uterus Health, and Milk Production in Transitioning Goats
Authors: Hashem Nesrein M. , Morsy Amr S. , Soltan Yosra A. , Sallam Sobhy M.
Published: September 2021

As an attempt to prevent transition-period-associated metabolic disorders and/or diseases, the potential benefits of Boswellia sacra (Bs) resin on hematology, immunity, metabolic status, udder and uterus health biomarkers, and milk production were examined in transitioning goats. From 2 weeks prepartum to 7 weeks postpartum, goats (n = 7/treatment) orally received 0 (control, nBS), 2 (BsL), or 4 (BsH) g of Bs resin/goat/day. The results showed that both Bs treatments significantly improved the activity of phagocytes. Both Bs treatments significantly decreased the concentrations of blood plasma urea, non-esterified fatty acids, hydroxybutyric acid, and interleukin-1β, whereas they increased the total antioxidant capacity compared with the nBS treatment. Both Bs treatments significantly decreased the uterine horn diameter and tended to decrease the intrauterine fluid content, indicating improved uterine involution compared with no treatment. Compared with the nBS treatment, both Bs treatments significantly decreased the milk somatic cell count. The lowest milk interleukin-1β content was observed in goats that received the BsL treatment, followed by those that received the BsH and nBS treatments. The BsL treatment significantly increased the concentration of immunoglobulin M (IgM) in the colostrum compared with the other treatments. Both Bs treatments significantly increased the daily milk yield compared with the nBS treatment but did not affect milk composition or the fat-to-protein ratio. In conclusion, supplementing lactating goats in the transition period with Bs resin at a dose of 2 g/goat/day positively affected the body lipid metabolism, udder and uterus health, colostrum IgM content, and milk yield due to its antioxidant and anti-inflammatory effects.
Evaluation of Methionine Sources in Protein Reduced Diets for Turkeys in the Late Finishing Period Regarding Performance, Footpad Health and Liver Health
Authors: Lingens Jan Berend , Abd El-Wahab Amr , de Paula Dorigam Juliano Cesar , Lemme Andreas , Brehm Ralph , Langeheine Marion , Visscher Christian
Published: September 2021

Footpad dermatitis and hepatic lipidosis are health problems in fattening turkeys where a positive influence of higher methionine content in feed is discussed. The effects of the methionine supplements DL-methionine (DLM) and liquid methionine hydroxyl analogue free acid (MHA-FA) under the aspect of low protein diets were investigated in this study based on performance parameters, footpad health, liver health and oxidative stress. In this study, 80 female turkeys (B.U.T. Big 6) of 63 day-old, were randomly assigned to four groups characterising a 2 × 2 factorial design with five replicates each over five weeks. The groups were fed with diets differing in methionine source (DLM vs. MHA-FA, assuming a biological activity of MHA-FA of 65%) and crude protein content (15% vs. 18%) for 35 days. The results showed no significant interactions between the protein content and methionine source. Strong protein reduction significantly impaired water intake, feed intake, weight gain and feed conversation ratio, but improved footpad health. DLM and MHA-FA addition had no significant effect on weight gain, crude fat and protein contents in the liver, but DLM resulted in a significant increase in livers antioxidative capacity compared to MHA-FA. Although the protein reduction resulted in reduced performance, the study showed that MHA-FA can be replaced by DLM in a 100:65 weight ratio without compromising performance but with certain advantages in the antioxidative capacity of the liver.
High Density and Uniform Plant Distribution Improve Soybean Yield by Regulating Population Uniformity and Canopy Light Interception
Authors: Xu Cailong , Li Ruidong , Song Wenwen , Wu Tingting , Sun Shi , Han Tianfu , Wu Cunxiang
Published: September 2021

Optimizing the spatial distribution of plants under normal conditions of water and fertilizer is widely used by farmers to improve soybean yield. However, the relationship between soybean yield and spatial plant distribution in the field has not been well studied. This study examined the effect of planting density and plant distribution pattern on soybean plant growth, yield components, canopy light interception, and dry matter accumulation. We also analyzed the relationship between photosynthetic rate, dry matter accumulation, and yield under different planting densities and plant distribution. A two year field experiment was conducted during the 2018 and 2019 soybean planting seasons. Two planting densities (1.8 × 105 and 2.7 × 105 plants ha−1) and two plant distribution patterns (uniform and non-uniform plant spacing) were tested. Higher planting density significantly increased the canopy light interception and dry matter accumulation during soybean growth, leading to increased soybean productivity. The seed yield of soybean under higher planting density was 22.8% higher than under normal planting density. Soybean planted under uniform spacing significantly reduced the differences plant-to-plant. Uniform plant spacing significantly increased the canopy light interception and dry matter accumulation of the soybean population. In addition, the coefficient of variation of seed weight per plant between individual plants under uniform plant distribution decreased by 71.5% compared with non-uniform plant distribution. Furthermore, uniform plant distribution increased soybean seed yield by 9.5% over non-uniform plant distribution. This study demonstrates that increasing planting density under uniform plant distribution can be useful to obtain higher seed yield without increasing other farm inputs.
Rumen (Calicophoron/Paramphistomum spp.) and Liver Flukes (Fasciola hepatica) in Cattle—Prevalence, Distribution, and Impact of Management Factors in Germany
Authors: Forstmaier Tanja , Knubben-Schweizer Gabriela , Strube Christina , Zablotski Yury , Wenzel Christoph
Published: September 2021

This study was carried out to determine the prevalence of rumen flukes on German cattle farms via the sedimentation technique, and to identify the rumen fluke species occurring in Germany. Additionally, the prevalence of patent Fasciola hepatica infections was determined. Furthermore, a short questionnaire was answered by the farmers. A prevalence of 5.5% and 9.5% was detected for rumen flukes and liver flukes, respectively. Coinfections occurred on 2.1% of farms. In northern Germany, the rumen fluke prevalence was higher than in southern Germany, while for liver fluke the distribution was reversed. Rumen flukes were mostly identified as Calicophoron daubneyi, but in four cases, sequencing revealed Paramphistomum leydeni for the first time in Germany. Grazing and feeding of fresh grass, as well as organic farming, were significantly associated with rumen and liver fluke occurrence. In contrast, suckler cow husbandry only had an influence on the occurrence of rumen flukes, but not liver flukes. Trematode eggs could be detected in both, farms with and without deworming. Since there were only a few studies about Paramphistomidosis in Germany, more attention should be paid to these parasitic diseases for animal welfare and animal health reasons.
Feed Intake Parameters of Horses Fed Soaked or Steamed Hay and Hygienic Quality of Hay Stored following Treatment
Authors: Glatter Maren , Bochnia Mandy , Wensch-Dorendorf Monika , Greef Jörg Michael , Zeyner Annette
Published: September 2021

Horses suffering from equine asthma must consume low-dust forage, with soaking and steaming being suitable methods of hay treatment. The impacts of this treated hay’s subsequent storage and effects on the horses’ chewing activity are largely unknown. Meadow hay was soaked (10–15 °C, 15 min) or steamed (100 °C, 60 min). Microbial counts (colony forming units (CFU)) were determined by culture before and after soaking or steaming, and subsequent storage at 10 and 25 °C for 6, 12 and 24 h (three replicates each). Six horses were fed native, soaked and steamed hay, according to a cross-over design, and chewing parameters were measured. Steaming reduced (p < 0.05) typical mold vs. soaking (0 vs. 50 CFU/g) and yeasts vs. native and steamed hay (0 vs. 102 and 90 CFU/g). Storing soaked hay elevated bacteria, mold, and yeasts (p < 0.05). Within the first 60 min of hay intake, the steamed hay and soaked hay were eaten slower (19.5 and 21.5 g dry matter/min, respectively; p < 0.05) and the steamed hay was chewed more intensely (steamed hay: 3537; native: 2622; and soaked: 2521 chewing cycles/kg dry matter, p < 0.05). Steaming particularly improves the hygienic quality of hay. Soaked hay is not stable when stored and is less accepted by horses.
The Conservation of Native Domestic Animal Breeds in Nordic Countries: From Genetic Resources to Cultural Heritage and Good Governance
Authors: Ovaska Ulla , Bläuer Auli , Kroløkke Charlotte , Kjetså Maria , Kantanen Juha , Honkatukia Mervi
Published: September 2021

Native breeds are domestic animal populations that have adapted to their habitats. The genetic value of breeds has been known for a long time, and recently more attention has been paid to their cultural value. Due to both ecological and cultural significance, it is important that native breeds continue to be bred in their native environments. This is supported by various financial support schemes. Support schemes rarely cover the financial gap in output compared to commercial breeds. A solution to this has been sought in special products, such as cheese or wool, and other businesses, such as animal-assisted care and tourism. Less attention has been paid to the role of administration and good governance in the maintenance of native breeds. In this study, a questionnaire was sent to all registered keepers of native breeds in Finland. This survey clarified their reasons for keeping native breeds and their ideas for improving governance structures and practices. The results were discussed in stakeholder workshops, and in a Nordic context. The results show that genetic and cultural values are recognised in several documents and programmes, but farmers need to be engaged more in the design of support schemes and practices.
Hormonal and Neurological Aspects of Dog Walking for Dog Owners and Pet Dogs
Authors: Akiyama Junko , Ohta Mitsuaki
Published: September 2021

The hormone oxytocin is involved in various aspects of the relationship between humans and animals. Dog walking is a common activity for dog owners and their dogs. The walk, of course, should be good for the health of the dog as well as its owner. In Experiment I, we assessed whether salivary oxytocin and cortisol in dog owners changed because of walking their dogs. Ten owners walked with their dogs and walked alone. Similar to other previous research, walking with a dog did not significantly change oxytocin and cortisol. Therefore, in Experiment II, we investigated the effect of dog walking on brain noradrenergic and GABAergic neural activity, as indicated by salivary MHPG and GABA, in 14 dog owners. Walking with a dog reduced salivary MHPG compared to walking alone, and MHPG was correlated negatively with GABA. Thus, dog walking activated GABAergic nerves in the brain and suppressed noradrenergic nerves, effectively relieving stress.
Effects of Garlic Allium sativum Powder on Nutrient Digestibility, Haematology, and Immune and Stress Responses in Eurasian Perch Perca fluviatilis Juveniles
Authors: Zare Mahyar , Tran Hung Quang , Prokešová Marketa , Stejskal Vlastimil
Published: September 2021

The supplementation of fish diets with phytogenics can increase growth performance and can modulate immune system response. European perch Perca fluviatilis (initial weight 25.0 ± 0.4 g) were fed a diet including 0 (Control), 10 (G10), 20 (G20), and 30 (G30) g kg−1 garlic powder. No significant difference in the growth parameters and somatic indices were observed. Significantly higher fat digestibility was observed in G10 and G30 diets compared to in the control and G20 diets(p < 0.05). Significantly greater red blood cell and white blood cell counts were observed with the G10 diet (p < 0.05). Garlic significantly decreased serum cholesterol in all of the experimental groups. Serum albumin was significantly higher in the G10 and G20 diets (p < 0.05). Immediately after the overcrowding stress challenge, the garlic groups showed significantly higher cortisol levels than the control group, while no significant difference was observed in the glucose concentration among groups. At 1 h post-stress, all of the groups that had been fed a garlic-supplemented diet showed lower cortisol levels than the control group, and this trend was maintained at 6 and 24 h post stress (p < 0.05), and glucose level in all garlic groups was significantly lower than control (p < 0.05). Garlic at 10 g kg−1 in feed can improve apparent fat digestibility and selected blood parameters and can enhance resistance against high-density and net handling stress in Eurasian perch.
Judgement Bias in Miniature Donkeys: Conditioning Factors and Personality Links
Authors: Pinto Maria , Navas González Francisco Javier , Heleski Camie , McLean Amy
Published: September 2021

Expectation-related bias may configure individuals’ perception of their surrounding environment and of the elements present in it. This study aimed to determine the repercussions of environmental (weather elements) or subject-inherent factors (sex, age, or personality features) on judgment bias. A cognitive bias test was performed in eight Miniature jennies and four jacks. Test comprised habituation, training and testing phases during which subjects were trained on how to complete the test and scored based on their latency to approach an ambiguous stimulus. A questionnaire evaluating eleven personality features was parallelly completed by three caretakers, five operators and two care assistants to determine the links between personality features and judgment bias. Adjusted latencies did not significantly differ between sexes (Mann–Whitney test, p > 0.05). Although Miniature donkeys can discriminate positive/negative stimuli, inter-individual variability evidences were found. Such discrimination is evidenced by significant latency differences to approach positive/negative stimuli (33.7 ± 43.1 vs. 145.5 ± 53.1 s) (Mann–Whitney test, p < 0.05). Latencies significantly increased with patience, indicative of an expression of pessimism. Better understanding judgement bias mechanisms and implications may help optimize routine handling practices in the framework of animal welfare.
Investigations on Transfer of Pathogens between Foster Cows and Calves during the Suckling Period
Authors: Köllmann Katharina , Wente Nicole , Zhang Yanchao , Krömker Volker
Published: September 2021

To date, there have been few studies on the health effects of foster cow systems, including the transmission of mastitis-associated pathogens during suckling. The present study aimed to compare the pathogens detected in the mammary glands of the foster cow with those in the oral cavities of the associated foster calves and to evaluate the resulting consequences for udder health, calf health and internal biosecurity. Quarter milk sampling of 99 foster cows from an organic dairy farm was conducted twice during the foster period. Oral cavity swabs were taken from 345 foster calves. Furthermore, quarter milk samples were collected from 124 biological dams to investigate possible transmission to the foster cows via the suckling calves. All samples were microbiologically examined and confirmed by MALDI-TOF (matrix-assisted laser desorption time-of-flight mass-spectrometry). Using RAPD-PCR (randomly amplified polymorphic DNA polymerase chain reaction), strain similarities were detected for Pasteurella multocida, Staphylococcus aureus, S. sciuri and Streptococcus (Sc.) suis. Transmission of P. multocida and S. aureus probably occurred during suckling. For S. sciuri and Sc. suis, environmental origins were assumed. Transmission from dam to foster cow with the suckling calf as vector could not be clearly demonstrated.
In Vitro Supplementation of Copper Modulates the Functional Th1/Th2 Phenotype of Peripheral Blood Mononuclear Cells in Cattle
Authors: Bunting Michaela , Challice Bethan , Gibson Amanda , van Winden Steven
Published: September 2021

This study investigated the association of copper levels and monocyte plasticity between M1 (CD14+ CD16−) and M2 (CD14− CD16++) phenotypes. Five samples of female bovine PBMCs were incubated in 0, 4, 8 and 16 μM copper and stimulated (PPD-A, TLR- 2 ligand (Pam3CSK4), or media alone) before they were washed and stained for cell surface expression analysis by flow cytometry. M1 function was measured through nitric oxide production using a Griess assay. Flow cytometry analysis showed a significant reduction in viability with increased copper (p < 0.001). Increasing copper had a significant impact on CD14 expression (p = 0.026) and in cows older than 4 years copper levels positively affected CD14 expression (p = 0.001), whereas in animals of four years or younger, Cu did not affect the CD14 expression (p = 0.701 and 0.939, respectively). CD14 expression affected both CD16 expression and NO production. For CD16 expression, there was a further significant negative effect of copper levels in cows older than 4 years, NO was not affected by varying copper levels. In our small sample, monocytes in the presence of a higher copper environment showed a stronger M1 support for better cellular immunity which might contain intracellular infections more effectively. To test this, a randomised clinical trial will be required to determine whether copper supplementation could prevent progression to Johne’s disease in MAP infected cows.
The Effect of Freezing Sheep’s Milk on the Meltability, Texture, Melting and Fat Crystallization Profiles of Fresh Pasta Filata Cheese
Authors: Biegalski Jakub , Cais-Sokolińska Dorota , Tomaszewska-Gras Jolanta , Baranowska Hanna M.
Published: September 2021

Sheep’s milk is produced in smallholdings, which hinders the continuity of production. Therefore, freezing during periods of high production can be a solution. Herein, we examined the effect of freezing on sheep’s milk and a mixture of sheep and cow’s milk (70:30, v/v) on the quality of fresh pasta filata cheeses produced from the milk. Frozen/thawed sheep’s milk contributes little to the development of innovative and reformulated cheeses. This was due to 24% higher hardness and greater extensibility and cutting force, as well as lower stretching and elasticity. Although their flowability increased (Oiling-off from 3 to 12%), the meltability (tube test, and Schreiber test) decreased. Additionally, the use of frozen milk caused consumer dissatisfaction. The consumer penalty analysis of the just–about–right showed that freezing of the milk caused the loss of the refreshing, elasticity and shininess of pasta filata cheeses.
Insights into the Genetic Evolution of Duck Hepatitis A Virus in Egypt
Authors: Rohaim Mohammed A. , Naggar Rania F. El , AbdelSabour Mohammed A. , Ahmed Basem A. , Hamoud Mohamed M. , Ahmed Kawkab A. , Zahran Osama K. , Munir Muhammad
Published: September 2021

Duck hepatitis virus (DHV) is one of the commercially important diseases of ducklings worldwide. It is an acute and highly infectious disease of ducklings caused by three different serotypes (1–3) of duck hepatitis A virus (DHAV), and serotype 1 is the most common in poultry. To date, little is known about the prevalence and genetic characterisation of DHAV-1 in Egypt. In the current study, isolation and complete genomic analyses of DHAVs circulating in commercial duck farms in different Egyptian governorates were conducted. A total of eighteen samples were collected from six Egyptian governorates of 3–11 days old ducklings (Pekin and Mullard) with a history of nervous signs and high mortality rates. Five out of eighteen (5/18) samples were screened positive for the DHAV-1 based on the VP1 gene. These samples were individually used for virus isolation in embryonated duck embryos (EDE), followed by complete genome sequencing. Phylogenomic analyses showed that DHAV serotype I; genotype I were diversified into four different groups (1–4). Most of the recent circulating Egyptian DHAV strains are clustered within group 4, while isolates characterised within this study were clustered within group 1. Recombination analyses revealed that the emergence of a new recombinant virus—DHAV-1 strain Egypt-10/2019—through recombination. Likewise, the selective pressure analyses showed the existence, inside or near areas of the viral attachment or related functions, of positive scores highlighting the importance of natural selection and viral evolution mechanism at different protein domains. The findings of this study provide updated information on the epidemiological and genetic features of DHAV-1 strains and underscore the importance of DHAV surveillance as well as re-evaluation for currently used vaccines.
Pet–Human Relationships: Dogs versus Cats
Authors: González-Ramírez Mónica Teresa , Landero-Hernández René
Published: September 2021

The study of human–animal interactions has increased, focusing on the dog–owner relationship, leaving a lag in research on the cat–owner relationship and practically a total absence of studies that compare the dog–owner relationship with the cat-owner relationship. Therefore, the objective of the present study was to make this comparison based on the perception of people living with both dogs and cats, considering interaction, emotional closeness, and perceived cost of the relationship. A total of 132 residents in Mexico participated. To evaluate the pet–human relationship, the dog and cat versions of the Monash dog owner relationship scale were used, thus obtaining comparable scores for the relationship with dogs and cats. Based on what the owners reported, significant differences were found. Relationships with cats were better than relationships with dogs, a finding that was confirmed when comparing male dogs and cats and when comparing female dogs and cats. It was concluded that relationships with cats are better because the perceived cost of such a relationship is lower. However, emotional closeness is greater with dogs than with cats.
Periprosthetic Infections of the Shoulder Joint: Characteristics and 5-Year Outcome of a Single-Center Series of 19 Cases
Authors: Bdeir Mohamad , Dally Franz-Joseph , Assaf Elio , Gravius Sascha , Mohs Elisabeth , Hetjens Svetlana , Darwich Ali
Published: September 2021

Periprosthetic shoulder infection (PSI) remains a devastating complication after total shoulder arthroplasty (TSA). Furthermore, there is a paucity in the literature regarding its diagnostic and therapeutic management, especially the absence of therapy concepts devised exclusively for PSI. The aim of the presenting study is to examine the characteristics and outcome of patients with PSI who were treated according to well-established algorithms developed originally for periprosthetic joint infection (PJI) of the hip and knee and determine if these algorithms can be applied to PSI. This single-center case series included all patients with a PSI presenting between 2010 and 2020. Recorded parameters included age, sex, affected side, BMI, ASA score, Charlson comorbidity index, preoperative anticoagulation, indication for TSA (fracture, osteoarthritis or cuff-arthropathy), and type of infection (acute or chronic PSI). The outcome was divided into treatment failure or infect resolution. Staphylococcus epidermidis and aureus were the commonest infecting pathogens. Acute PSI was mainly treated with debridement, irrigation, and retention of the prosthesis (DAIR) and chronic cases with two/multiple-stage exchange. The treatment failure rate was 10.5%. C-reactive protein was preoperatively elevated in 68.4% of cases. The mean number of operative revisions was 3.6 ± 2.6, and the mean total duration of antibiotic treatment was 72.4 ± 41.4 days. The most administered antibiotic was a combination of clindamycin and fluoroquinolone. In summary, the data of the current study suggest that therapeutical algorithms and recommendations developed for the treatment of PJI of the hip and knee are also applicable to PSI.
MaLang: A Decentralized Deep Learning Approach for Detecting Abusive Textual Content
Authors: Kompally Pranav , Sethuraman Sibi Chakkaravarthy , Walczak Steven , Johnson Samuel , Cruz Meenalosini Vimal
Published: September 2021

Cyberbullying is a growing and significant problem in today’s workplace. Existing automated cyberbullying detection solutions rely on machine learning and deep learning techniques. It is proven that the deep learning-based approaches produce better accuracy for text-based classification than other existing approaches. A novel decentralized deep learning approach called MaLang is developed to detect abusive textual content. MaLang is deployed at two levels in a network: (1) the System Level and (2) the Cloud Level, to tackle the usage of toxic or abusive content on any messaging application within a company’s networks. The system-level module consists of a simple deep learning model called CASE that reads the user’s messaging data and classifies them into abusive and non-abusive categories, without sending any raw or readable data to the cloud. Identified abusive messages are sent to the cloud module with a unique identifier to keep user profiles hidden. The cloud module, called KIPP, utilizes deep learning to determine the probability of a message containing different categories of toxic content, such as: ‘Toxic’, ‘Insult’, ‘Threat’, or ‘Hate Speech’. MaLang achieves a 98.2% classification accuracy that outperforms other current cyberbullying detection systems.
Effects of Simulated Gastric Acid Exposure on Surface Topography, Mechanical and Optical Features of Commercial CAD/CAM Ceramic Blocks
Authors: Pîrvulescu Ioana Ligia , Pop Daniel , Moacă Elena-Alina , Mihali Ciprian-Valentin , Ille Codruța , Jivănescu Anca
Published: September 2021

Gastric acid exposure produces tooth structure demineralization and dental ceramic degradation. The most affected patients are those who suffer from gastroesophageal reflux disease, bulimia nervosa, and pregnant women with prolonged severe nausea. In order to protect this kind of patient, the purpose of this study was to determine whether simulated gastric acid exposure leads to microstructural changes in surface topography, hardness, color changes, and translucency of some ceramic materials, which are already on the market. Forty disks (Triluxe Forte, Cerasmart, Enamic and Empress CAD) were analyzed before and after immersion in simulated gastric acid juice, in terms of microhardness, surface roughness, translucency, and surface morphology using scanning electron microscopy. Color change was assessed by using a spectrophotometer based on CIELab parameters and the results showed that, after exposure, ∆Eab remained under the threshold of acceptability and perceptibility. In terms of microhardness, Cerasmart is the only material that did not undergo changes after immersion. SEM images illustrated observable changes surface topography after acid exposure for all the tested materials. In conclusion, Triluxe Forte suffered the most important changes after simulated gastric acid juice exposure, and Cerasmart proved to be the least affected material.
Intra-Articular Hybrid Hyaluronic Acid Injection Treatment in Overweight Patients with Knee Osteoarthritis: A Single-Center, Open-Label, Prospective Study
Authors: Scaturro Dalila , Vitagliani Fabio , Terrana Pietro , Cuntrera Daniele , Falco Vincenzo , Tomasello Sofia , Letizia Mauro Giulia
Published: September 2021

Background: A BMI > 25 is the most decisive, albeit modifiable, risk factor for knee osteoarthritis (KOA). This study aimed at assessing the efficacy of intra-articular injections of hybrid hyaluronic acid (HA) complexes (Sinovial® H-L) for the treatment of KOA in overweight patients in terms of disease severity, cardiocirculatory capacity, and quality of life. Materials: In this single-site, open-label, prospective trial, 37 patients with symptomatic knee OA were assessed at baseline and 3 months after ultrasound-guided intra-articular injection of hybrid HA complexes (Sinovial® H-L). Results: Primary variables displaying a statistically significant improvement after treatment were pain (VAS), disease severity (WOMAC), and cardiopulmonary capacity (6 min walk test). Among secondary variables, quality of life (SF-12) improved significantly, as did analgesic intake for pain control. No statistically significant difference was observed in body fat and muscle mass percentage measured by bioelectrical impedance analysis. Conclusions: Intra-articular hybrid HA injections are significantly effective in improving OA-related disease severity, cardiopulmonary function, and analgesic intake. This supports the role of hybrid HA viscosupplementation as a nonpharmacological treatment to relieve pain, reduce disability, improve quality of life, and limit the risk of polypharmacy in overweight patients with knee OA.
Light Propagation in Confined Nematic Liquid Crystals and Device Applications
Authors: d’Alessandro Antonio , Asquini Rita
Published: September 2021

Liquid crystals are interesting linear and nonlinear optical materials used to make a wide variety of devices beyond flat panel displays. Liquid crystalline materials can be used either as core or as cladding of switchable/reconfigurable waveguides with either an electrical or an optical control or both. In this paper, materials and main device structures of liquid crystals confined in different waveguide geometries are presented using different substrate materials, such as silicon, soda lime or borosilicate glass and polydimethylsiloxane. Modelling of the behaviour of liquid crystal nanometric molecular reorientation and related refractive index distribution under both low-frequency electric and intense optical fields is reported considering optical anisotropy of liquid crystals. A few examples of integrated optic devices based on waveguides using liquid crystalline materials as core for optical switching and filtering are reviewed. Reported results indicate that low-power control signals represent a significant feature of photonic devices based on light propagation in liquid crystals, with performance, which are competitive with analogous integrated optic devices based on other materials for optical communications and optical sensing systems.
Quantitative Interpretation of TOC in Complicated Lithology Based on Well Log Data: A Case of Majiagou Formation in the Eastern Ordos Basin, China
Authors: Hu Shuiqing , Zhang Haowei , Zhang Rongji , Jin Lingxuan , Liu Yuming
Published: September 2021

Source rock evaluation plays a key role in studies of hydrocarbon accumulation and resource potential. Total organic carbon (TOC) is the basis of source rock evaluation and it is a key parameter that influences petroleum resource assessment. The Majiagou formation in the eastern Ordos Basin has complicated lithology and low abundance of organic matters. There are different opinions over the existence of scale source rocks. Due to inadequate laboratory data of TOC in the Ordos Basin, it is difficult to accurately describe source rocks in the region; thus, log interpretation of TOC is needed. In this study, the neural network model in the artificial intelligence (AI) field was introduced into the TOC logging interpretation. Compared with traditional ΔlogR methods, sample optimization, logging correlation analysis and comparative optimization of computational methods were carried out successively by using measured TOC data and logging data. Results show that the neural network model has good prediction effect in complicated lithologic regions and it can identify variations of TOC in continuous strata accurately regardless of the quick lithologic changes.
Treatment Option Criteria for Open Bite with Receiver Operating Characteristic Analysis—A Retrospective Study
Authors: Tachiki Chie , Nishii Yasushi , Yamamoto Masae , Takaki Takashi
Published: September 2021

Temporary anchorage devices (TADs) allow molar intrusion as an additional treatment option to conventional treatment for open bite cases. We investigated the treatment option criteria for open bite treatment. A total of 33 patients with skeletal Class I to Class II open bite who had stable occlusion one year after treatment were enrolled in the study, including 15 patients who had undergone surgical orthodontic treatment, 8 patients who had undergone treatment with molar intrusion, and 10 patients who had undergone treatment with anterior teeth extrusion. Pre-treatment cephalometric analysis of these patients was used for comparison. Furthermore, receiver operating characteristic (ROC) curve analysis was employed to examine the measurement parameters that would be valid as treatment criteria. In the results, FMA showed that patients treated with molar intrusion had a moderately high angle, while those treated with surgical orthodontic treatment had a severe high angle. The area under the curve (AUC) of the ROC curve indicated that FMA is the most appropriate parameter for treatment option criteria. In addition, the cutoff value indicated that the borderline between molar intrusion and surgical orthodontic treatment was 37.5° for FMA. In this study, we suggested criteria for the treatment of open bite with molar intrusion.
Reusing Monolingual Pre-Trained Models by Cross-Connecting Seq2seq Models for Machine Translation
Authors: Oh Jiun , Choi Yong-Suk
Published: September 2021

This work uses sequence-to-sequence (seq2seq) models pre-trained on monolingual corpora for machine translation. We pre-train two seq2seq models with monolingual corpora for the source and target languages, then combine the encoder of the source language model and the decoder of the target language model, i.e., the cross-connection. We add an intermediate layer between the pre-trained encoder and the decoder to help the mapping of each other since the modules are pre-trained completely independently. These monolingual pre-trained models can work as a multilingual pre-trained model because one model can be cross-connected with another model pre-trained on any other language, while their capacity is not affected by the number of languages. We will demonstrate that our method improves the translation performance significantly over the random baseline. Moreover, we will analyze the appropriate choice of the intermediate layer, the importance of each part of a pre-trained model, and the performance change along with the size of the bitext.
Parametric Optimization of the GMAW Welding Process in Thin Thickness of Austenitic Stainless Steel by Taguchi Method
Authors: Nobrega Glauco , Souza Maria Sabrina , Rodríguez-Martín Manuel , Rodríguez-Gonzálvez Pablo , Ribeiro João
Published: September 2021

In the present work, an analysis of different welding parameters was carried out on the welding of stainless-steel thin thickness tubes by the Gas Metal Arc Welding (GMAW) process. The influence of three main parameters, welding voltage, movement angle, and welding current in the quality of the welds, was studied through a specifically designed experimental process based on the establishment of three different levels of values for each of these parameters. Weld quality is evaluated using destructive testing (macrographic analysis). Specifically, the width and root penetration of the weld bead were measured; however, some samples have been disregarded due to welding defects outside the permissible range or caused by excessive melting of the base metals. Data are interpreted, discussed, and analyzed using the Taguchi method and ANOVA analysis. From the analysis of variance, it was possible to identify the most influential parameter, the welding voltage, with a contribution of 43.55% for the welding penetration and 75.26% for the bead width, which should be considered in the designs of automatic welding processes to improve the quality of final welds.
Chemical Composition and Source Apportionment of Total Suspended Particulate in the Central Himalayan Region
Authors: Sheoran Rahul , Dumka Umesh Chandra , Kaskaoutis Dimitris G. , Grivas Georgios , Ram Kirpa , Prakash Jai , Hooda Rakesh K. , Tiwari Rakesh K. , Mihalopoulos Nikos
Published: September 2021

The present study analyzes data from total suspended particulate (TSP) samples collected during 3 years (2005–2008) at Nainital, central Himalayas, India and analyzed for carbonaceous aerosols (organic carbon (OC) and elemental carbon (EC)) and inorganic species, focusing on the assessment of primary and secondary organic carbon contributions (POC, SOC, respectively) and on source apportionment by positive matrix factorization (PMF). An average TSP concentration of 69.6 ± 51.8 µg m−3 was found, exhibiting a pre-monsoon (March–May) maximum (92.9 ± 48.5 µg m−3) due to dust transport and forest fires and a monsoon (June–August) minimum due to atmospheric washout, while carbonaceous aerosols and inorganic species expressed a similar seasonality. The mean OC/EC ratio (8.0 ± 3.3) and the good correlations between OC, EC, and nss-K+ suggested that biomass burning (BB) was one of the major contributing factors to aerosols in Nainital. Using the EC tracer method, along with several approaches for the determination of the (OC/EC)pri ratio, the estimated SOC component accounted for ~25% (19.3–29.7%). Furthermore, TSP source apportionment via PMF allowed for a better understanding of the aerosol sources in the Central Himalayan region. The key aerosol sources over Nainital were BB (27%), secondary sulfate (20%), secondary nitrate (9%), mineral dust (34%), and long-range transported mixed marine aerosol (10%). The potential source contribution function (PSCF) and concentration weighted trajectory (CWT) analyses were also used to identify the probable regional source areas of resolved aerosol sources. The main source regions for aerosols in Nainital were the plains in northwest India and Pakistan, polluted cities like Delhi, the Thar Desert, and the Arabian Sea area. The outcomes of the present study are expected to elucidate the atmospheric chemistry, emission source origins, and transport pathways of aerosols over the central Himalayan region.
Success of Thrombectomy in Management of Ischemic Stroke in Two Patients with SynCardia Total Artificial Heart in Bridge-to-Transplantation
Authors: Le Picault Brendan , David Charles-Henri , Alexandre Pierre-Louis , Lenoble Cédric , Bizouarn Philippe , Lepoivre Thierry , Groleau Nicolas , Rozec Bertrand , Desal Hubert , Roussel Jean-Christian , Sénage Thomas
Published: September 2021

Introduction: Circulatory assistance from a SynCardia Total Artificial Heart (SynCardia-TAH) is a reliable bridge-to-transplant solution for patients with end-stage biventricular heart failure. Ischemic strokes affect about 10% of patients with a SynCardia-TAH. We report for the first time in the literature two successful thrombectomies to treat the acute phase of ischemic stroke in two patients treated with a SynCardia-TAH in the bridge-to-transplant (BTT). Case report: We follow two patients with circulatory support from a SynCardia-TAH in the bridge-to-transplant for terminal biventricular cardiac failure with ischemic stroke during the support period. An early in-hospital diagnosis enables the completion of a mechanical thrombectomy within the first 6 h of the onset of symptoms. There was no intracranial hemorrhagic complication during or after the procedure and the patients fully recovered from neurological deficits, allowing a successful heart transplant. Conclusion: This case report describes the possibility of treating ischemic strokes under a SynCardia-TAH by mechanical thrombectomy following the same recommendations as for the general population with excellent results and without any hemorrhagic complication during or after the procedure.
Idebenone Decreases Aβ Pathology by Modulating RAGE/Caspase-3 Signaling and the Aβ Degradation Enzyme NEP in a Mouse Model of AD
Authors: Lee Hyun-ju , Jeong Ha-Ram , Park Jin-Hee , Hoe Hyang-Sook
Published: September 2021

The coenzyme Q10 analogue idebenone is an FDA-approved antioxidant that can cross the blood–brain barrier (BBB). The effects of idebenone on the pathology of Alzheimer’s disease (AD) and the underlying molecular mechanisms have not been comprehensively investigated. Here, we examined the impact of idebenone treatment on AD pathology in 5xFAD mice, a model of AD. Idebenone significantly downregulated Aβ plaque number via multi-directional pathways in this model. Specifically, idebenone reduced the RAGE/caspase-3 signaling pathway and increased levels of the Aβ degradation enzyme NEP and α-secretase ADAM17 in 5xFAD mice. Importantly, idebenone significantly suppressed tau kinase p-GSK3βY216 levels, thereby inhibiting tau hyperphosphorylation at Thr231 and total tau levels in 5xFAD mice. Taken together, the present study indicates that idebenone modulates amyloidopathy and tauopathy in 5xFAD mice, suggesting therapeutic potential for AD.
Stress-Induced Epstein-Barr Virus Reactivation
Authors: Sausen Daniel , Bhutta Maimoona , Gallo Elisa , Dahari Harel , Borenstein Ronen
Published: September 2021

Epstein-Barr virus (EBV) is typically found in a latent, asymptomatic state in immunocompetent individuals. Perturbations of the host immune system can stimulate viral reactivation. Furthermore, there are a myriad of EBV-associated illnesses including various cancers, post-transplant lymphoproliferative disease, and autoimmune conditions. A thorough understanding of this virus, and the interplay between stress and the immune system, is essential to establish effective treatment. This review will provide a summary of the interaction between both psychological and cellular stressors resulting in EBV reactivation. It will examine mechanisms by which EBV establishes and maintains latency and will conclude with a brief overview of treatments targeting EBV.
Role of UPR Sensor Activation in Cell Death–Survival Decision of Colon Cancer Cells Stressed by DPE Treatment
Authors: Benedetti Rossella , Gilardini Montani Maria Saveria , Romeo Maria Anele , Arena Andrea , Santarelli Roberta , D’Orazi Gabriella , Cirone Mara
Published: September 2021

Polyphenols have been shown to possess several beneficial properties, including properties involved in the prevention or treatment of cancer. Among these polyphenols, a leading role is played by dihydroxyphenylethanol (DPE), the most powerful antioxidant compound contained in the olive oil. DPE has been previously reported to induce endoplasmic reticulum (ER) stress and to reduce cell survival in colon cancer, one of the most common and aggressive cancers in developed countries. In this study, we further investigated the activation of UPR by DPE and explored the roles of the three UPR sensors, inositol-requiring enzyme (IRE) 1 alpha, protein kinase RNA-like endoplasmic reticulum kinase (PERK), and activating transcription factor (ATF6), in the cell death–survival decision of wt and mutp53 colon cancer cells and the underlying mechanisms involved. We also unveiled a new interplay between ATF6 and wt, as well as mutp53, which may have important implications in cancer therapy.
Nutraceuticals and Herbs in Reducing the Risk and Improving the Treatment of COVID-19 by Targeting SARS-CoV-2
Authors: Tagde Priti , Tagde Sandeep , Tagde Pooja , Bhattacharya Tanima , Monzur Shams , Rahman Md. , Otrisal Pavel , Behl Tapan , ul Hassan Syed , Abdel-Daim Mohamed , Aleya Lotfi , Bungau Simona
Published: September 2021

The worldwide transmission of acute respiratory syndrome coronavirus 2 (SARS-CoV-2) as a deadly or devastating disease is known to affect thousands of people every day, many of them dying all over the planet. The main reason for the massive effect of COVID-19 on society is its unpredictable spread, which does not allow for proper planning or management of this disease. Antibiotics, antivirals, and other prescription drugs, necessary and used in therapy, obviously have side effects (minor or significant) on the affected person, there are still not clear enough studies to elucidate their combined effect in this specific treatment, and existing protocols are sometimes unclear and uncertain. In contrast, it has been found that nutraceuticals, supplements, and various herbs can be effective in reducing the chances of SARS-CoV-2 infection, but also in alleviating COVID-19 symptoms. However, not enough specific details are yet available, and precise scientific studies to validate the approved benefits of natural food additives, probiotics, herbs, and nutraceuticals will need to be standardized according to current regulations. These alternative treatments may not have a direct effect on the virus or reduce the risk of infection with it, but these products certainly stimulate the human immune system so that the body is better prepared to fight the disease. This paper aims at a specialized literary foray precisely in the field of these “cures” that can provide real revelations in the therapy of coronavirus infection
Secondary Cerebellar Cortex Injury in Albino Male Rats after MCAO: A Histological and Biochemical Study
Authors: Alrafiah Aziza R.
Published: September 2021

The present study focused on secondary injury following the middle cerebral artery (MCA) occlusion in rats not linked to the MCA’s feeding zone. This entity has been very rarely studied. Additionally, this study investigated the rates of expression of five fundamental angiogenic biomarkers called endoglin, vascular endothelial growth factors-A (VEGF-A), endothelin-1 (ET-1), 2granulocyte colony-stimulating factor (G-CSF), and angiopoietin-using the MCA occlusion (MCAO) model. The random allocation of twelve adult male albino rats was in two groups. As a sham control group, six rats were used. This group was subjected to a sham operation without MCAO. The MCAO group consisted of six rats that were subjected to MCAO operation. After three days, the rats were sacrificed. The cerebellar specimens were immediately processed for light microscopic examination. An angiogenic biomarkers multiplex assay from multiplex was used to assess endoglin levels, VEGF-A, ET-1, angiopoietin-2, and G-CSF in serum samples. Hematoxylin and eosin-stained sections showed that the cerebellar cortex of rats of the MCAO group was more affected than the sham control group. Furthermore, Nissl stain and immunohistochemical analysis revealed an apparent increase in the number of positive immunoreactive in the cerebellar cortex and an evident decrease in Nissl granules in Purkinje cells of the MCAO rats, in contrast to the control rats. In addition, there was a significant increase in angiogenic factors VEGF-A, ET-1, angiopoietin-2, and endoglin. Interestingly, there was an increase in the G-CSF but a non-significant in the MCAO rats compared to the control rats. Furthermore, there was a significant correlation between the angiopoietin-2 and ET-1, and between G-CSF and ET-1. VEGF-A also exhibited significant positive correlations with the G-CSF serum level parameter, Endoglin, and ET-1. Rats subjected to MCAO are a suitable model to study secondary injury away from MCA’s feeding zone. Additionally, valuable insights into the association and interaction between altered angiogenic factors and acute ischemic stroke induced by MCAO in rats.