bluuebunny/crossref_metadata_2025 huggingface dataset:
Parenting behaviours among mothers of pre-schoolers on the autism spectrum: Associations with parenting stress and children’s externalising behaviour problems
Authors: Madarevic Melinda , van Esch Lotte , Lambrechts Greet , Ceulemans Eva , Van Leeuwen Karla , Noens Ilse
Published: April 2020

BACKGROUND Parents of pre-schoolers diagnosed with Autism Spectrum Disorder (ASD) report increased parenting stress (i.e., stress related to the parent role) and more behaviour problems of the child compared with parents of non-autistic pre-schoolers. Parenting stress and children’s behaviour problems are both associated with parenting behaviours, but have not yet been investigated together. METHOD 42 mothers of autistic and non-autistic pre-schoolers were observed during mother-child interaction and they reported on parenting behaviours, parenting stress, and children’s externalising behaviour problems. Spearman correlations between all variables were calculated for the ASD group and the non-ASD group separately, and Linear Mixed Models were built to investigate whether parenting stress and externalising behaviour problems were similarly associated to parenting behaviours in both groups. RESULTS Mothers in the ASD group reported more parenting stress and more externalising behaviour problems than mothers in the non-ASD group. In the ASD group only, parenting stress was related to externalising behaviour problems but not to the level of autism characteristics. In both groups, more externalising behaviour problems were associated with more observed negative parenting behaviours (i.e., criticising and ignoring the child), and more parenting stress was associated with less reported autonomy support. CONCLUSIONS Our findings indicate that in the case of possibly problematic parenting behaviours, such as negativity and lack of autonomy support, it is important to investigate associated factors like parenting stress and children’s behaviour problems. An individualised strengths and needs assessment could then offer a tailored intervention to families with an autistic pre-schooler.
The study of ontogenesis of Centaurea bipinnatifida (Trautv.) Tzvel. in the condition of the city of Karaganda
Authors: Asanova G.K. , Dodonova А.Sh. , Ishmuratova М.Yu. , Push W.
Published: April 2020

The results of the study of the ontogenesis of Centaurea bipinnatifidain the conditions of introduction of the city of Karaganda are presented in the article. The introduction into the culture of this species is due to the need for its preservation and reproduction in order to obtain biologically active substances. Four age periods (latent, virgin, generative and senile) and nine age states (seedlings, juvenile, immature, adult vegetative, young generative, middle age generative, old generative, sub-senile and senile) have been identified. Morphological features of each period and state, degree of development of above-ground and underground organs are determined. The duration of the small cycle of ontogenesis in the culture of Centaurea bipinnatifida was 3–4 years, in nature — 6–8 years. There has been an excess of crop plants over wild-growing individuals in size. The ontogenesis phases in culture are faster than under natural conditions.
Indicators of the cardiovascular system of 7–11 years old girls residing in Northern and Southern Kazakhstan
Authors: Tasbulatova G.S. , Umbetov A.U. , Sadykova B.S.
Published: April 2020

Functional characteristics are the leading criterion for assessing the health status of school students’. The body of a schoolchild in its aforementioned signs differs from the body of an adult. Schoolchildren are more sensitive to environmental factors. Physical condition may depend on age, gender, and location. The indicators of the cardiovascular system (CVS) of girls in the ontogenesis of 7–11 years in the city of Pavlodar and Kyzylorda were studied. In the article the results of a study of such indicators as heart rate (HR), systolic and diastolic blood pressure (SBP, DBP) are presented. Based on these data, pulse pressure (PP), double product (DP), reflecting the cost-effectiveness of the cardiovascular system, systolic blood volume (SBV) and minute blood volume (MBV), an indicator of blood circulation efficiency (BCE); Kerdo's vegetative index (KVI), reflecting the vegetative balance are calculated. The adaptation mechanisms and features of the reaction of the cardiovascular system to physical activity are revealed. Under the conditions of performing standard steregometric physical activity, heart rate (HR), double product (DP) of girls have significantly increased compared with the state of rest.
O genitivo de posse em português: um exercício de análise em semântica cognitiva
Authors: Lisboa Júnior Jorge Luiz Ferreira
Published: April 2020

O presente estudo dedica-se a análise da estrutura semântica e da polissemia do genitivo de posse em português. Tendo em vista análises da posse genitiva em termos de metáfora conceptual (NIKIFORIDOU, 1991; LANGACKER 1991) e da mereologia estrutural (LYONS, 1980), consideramos o problema da insuficiência de tais argumentos para a descrição da polissemia da posse. Como alternativa teórica e descritiva, postula-se que as construções de genitivo correspondam a padrões metonímicos associados a domínios de contiguidade (PEIRSMAN GEERAERTS, 2006), seja via transformação entre esquemas imagéticos de experiências contíguas, seja pelo mapeamento metafórico entre domínios de contiguidade. ---DOI: http://dx.doi.org/10.31513/linguistica.2019.v15n2a21413
Subclinical imaging changes in cerebral cavernous angiomas during prospective surveillance
Authors: Carrión-Penagos Julián , Zeineddine Hussein A. , Polster Sean P. , Girard Romuald , Lyne Seán B. , Koskimäki Janne , Romanos Sharbel , Srinath Abhinav , Zhang Dongdong , Cao Ying , Stadnik Agnieszka , Piedad Kristina , Shenkar Robert , Awad Issam A.
Published: April 2020

OBJECTIVE

The purpose of this study was to systematically assess asymptomatic changes (ACs), including subclinical hemorrhage, growth, or new lesion formation (NLF) during longitudinal follow-up of cerebral cavernous angiomas (CAs), and to correlate these with symptomatic hemorrhage (SH) during the same period and with clinical features of the disease.

METHODS

One hundred ninety-two patients were included in this study, among 327 consecutive patients with CA, prospectively identified between September 2009 and February 2019. Included patients had undergone clinical and MRI follow-up, in conjunction with institutional review board–approved biomarker studies, and harbored ≥ 1 CA with a maximum diameter of ≥ 5 mm on T2-weighted MRI. Rates of AC and SH per lesion-year and patient-year were assessed using prospectively articulated criteria. In multifocal/familial cases, rates of NLF were also assessed.

RESULTS

There were no differences in demographic or disease features among cases included or excluded in the study cohort, except for a higher proportion of included patients with CCM3 mutation. Follow-up was 411 patient-years (2503 lesion-years). The rate of AC was higher than the rate of SH (12.9% vs 7.5% per patient-year, and 2.1% vs 1.2% per lesion-year, both p = 0.02). Patients presenting with a prior history of SH had a higher rate of AC than those with other forms of presentation (19.7% and 8.2% per patient-year, respectively; p = 0.003). A higher rate of NLF on T2-weighted MRI (p = 0.03) was observed in patients with prior SH. Three of 6 solitary/sporadic and 2 of 28 multifocal/familial patients underwent resection of the lesion after AC.

CONCLUSIONS

Rates of AC are greater than SH during prospective follow-up of CAs, and greater in cases with prior SH. AC may be a more sensitive biomarker of lesional activity, and a more efficient surrogate outcome in clinical trials than SH. Patients experiencing an AC are more likely to undergo a surgical intervention when CAs are solitary/sporadic than when they are multifocal/familial.
Anterior selective stabilization combined with laminoplasty for cervical myelopathy due to massive ossification of the posterior longitudinal ligament: report of early outcomes in 14 patients
Authors: Nagamoto Yukitaka , Iwasaki Motoki , Okuda Shinya , Matsumoto Tomiya , Sugiura Tsuyoshi , Takahashi Yoshifumi , Furuya Masayuki
Published: April 2020

OBJECTIVE

Surgical management of massive ossification of the posterior longitudinal ligament (OPLL) is challenging. To reduce surgical complications, the authors have performed anterior selective stabilization combined with laminoplasty (antSS+LP) for massive OPLL since 2012. This study aimed to elucidate the short-term outcome of the antSS+LP procedure.

METHODS

The authors’ analysis was based on data from 14 patients who underwent antSS+LP for cervical myelopathy caused by massive OPLL and were followed up for at least 2 years after surgery (mean follow-up duration 3.3 years). Clinical outcome was evaluated preoperatively, at 6 months and 1 year postoperatively, and at the final follow-up using the Japanese Orthopaedic Association (JOA) scoring system for cervical myelopathy and the recovery rate of the JOA score. The following radiographic parameters were measured preoperatively, immediately after surgery, at 1 year after surgery, and at the final follow-up: the C2–7 angle, measured on lateral plain radiographs, and the segmental lordosis angle (SLA), measured on sagittal CT scans. The correlation between radiographic parameters and clinical outcomes was evaluated.

RESULTS

The mean JOA score increased from 10.4 before surgery to 13.6 and 13.8 at 6 months and 1 year after surgery, respectively; at the final follow-up the mean score was 13.4. This postoperative recovery was significant (p = 0.004) and was maintained until the final follow-up. No patient required revision surgery due to postoperative neurological deterioration. However, the C2–7 angle gradually deteriorated postoperatively. Similarly, the SLA was significantly increased immediately after surgery, but the improvement was not maintained. The recovery rate at the final follow-up correlated positively with the change in C2–7 angle (r = 0.60, p = 0.03) and the change in SLA (r = 0.72, p < 0.01).

CONCLUSIONS

AntSS+LP is safe and effective and may be an alternative to anterior decompression and fusion for the treatment of patients with massive OPLL. No postoperative neurological complications or significant postoperative exacerbation of neck pain were observed in our case series. Not only reducing intervertebral motion and decompressing the canal at the maximal compression level but also acquiring segmental lordosis at the maximal compression level are crucial factors for achieving successful outcomes of antSS+LP.
Sprawozdanie z czynności Archiwum i Muzeum Archidiecezjalnego oraz Biblioteki Kapitulnej we Wrocławiu za rok 1959
Authors: Urban Wincenty
Published: April 2020

-
Akta wizytacji podkrakowskiej parafii Zielonki z XVIII wieku w zasobie w Archiwum Kurii Metropolitalnej w Krakowie
Authors: Bulak Jan , Makarczyk Anna
Published: April 2020

W niniejszej publikacji autorzy prezentują osiemnastowieczne akta wizytacji podkrakowskiej parafii pw. Narodzenia Najświętszej Marii Panny w Zielonkach. Zabytkowy kościół z XIV wieku (większa część obecnego kościoła pochodzi z XVI wieku) przez lata był zależny od krakowskiej kapituły katedralnej, potem Akademii Krakowskiej (obecnie Uniwersytet Jagielloński) oraz kolegiaty św. Anny. Przybliżone zostały tutaj w formie edycji tekstu źródłowego trzy ostatnie wizytacje parafii Zielonki sprzed upadku Rzeczypospolitej: z 1727 roku (AVCap 61 oraz AV 23), z 1748 roku (AV 29 oraz Tabele Załuskiego 7) i z 1783 roku (AV 55). Księgi tych wizytacji są przechowywane w Archiwum Kurii Metropolitalnej w Krakowie (AKMKr), mieszczącym się przy ul. Franciszkańskiej 3. Wizytacje te to rękopisy w języku łacińskim oraz polskim z dużą liczbą zwrotów pochodzących z łaciny. Wyłącznie Tabele biskupa Załuskiego mają format drukowanego formularza, w którego rubryki odręcznie zostały naniesione stosowne informacje. Celem autorów było dokonanie możliwie wiernej edycji tych źródeł, aby udostępnić je szerszemu gronu odbiorców. Metodologia pracy skupiła się na rozwinięciu skrótów zastosowanych przez pisarzy, uwspółcześnieniu pisowni dla większej czytelności tekstu, a także dodaniu znaków diakrytycznych i znaków interpunkcyjnych w wymagających tego miejscach. Autorzy wzbogacili tekst przypisami tekstowymi, bibliograficznymi i terminologicznymi. Podjęte czynności edytorskie są zgodne z zasadami naukowej edycji źródeł historycznych dla tekstów nowożytnych. W rezultacie autorzy prezentują trzy pełne teksty wizytacji, wraz z inwentarzami, opatrzone wstępem, przypisami oraz bibliografią.
Ks. Johannesa Chrząszcza zapiski o I wojnie światowej. Sylwetka górnośląskiego historyka w 90. rocznicę śmierci
Authors: Górecki Piotr
Published: April 2020

Przypadająca w 2018 roku 90. rocznica śmierci ks. Johannesa Chrząszcza jest dobrą okazją, aby przybliżyć szerszemu gronu czytelniczemu sylwetkę tegoż górnośląskiego kapłana. Ks. Piotr Górecki w swoim artykule przybliża nie tylko sylwetkę ks. J. Chrząszcza, wspominając o najważniejszych wydarzeniach z jego kapłańskiego życia i prezentując spuściznę jego prac naukowych, liczącą 172 pozycje, głównie z historii Górnego Śląska. Na kanwie 100. rocznicy zakończenia I wojny światowej snuje przede wszystkim refleksję dotyczącą postawy tegoż śląskiego kapłana wobec władzy świeckiej. Źródłem badawczym stały się pozostawione przez ks. J. Chrząszcza zapiski kronikarskie, jakie zamieścił w książce o dziejach dwóch górnośląskich miejscowości – Toszka i Pyskowic. Lektura zapisków starszego już wówczas kapłana odkrywa przed nami ogromne dylematy, z jakimi borykał się on i współcześni mu duszpasterze. Wydaje się, że jego lojalna postawa miała na celu nie dopuścić do jakichkolwiek przewrotów i rewolt społecznych, nawet za cenę bezkompromisowej wierności względem władzy świeckiej i zachowania lansowanego przez wieki „sojuszu ołtarza z tronem”. Taka postawa cechowała także liczne grono innych duszpasterzy w okupowanych przez zaborców różnych częściach Polski. Dyskurs potwierdza tezę, że zarówno ks. J. Chrząszcz, jak i współcześni mu ludzie Kościoła byli swoistego rodzaju epigonami mijającej epoki. Nie zauważyli oni jutrzenki narodzin nowych czasów i nowego porządku, która przyniosła Polsce odrodzenie, a ziemi śląskiej nową nadzieję. W ocenie potomnych taka postawa ks. J. Chrząszcza była wystarczającym powodem do tego, aby nie uwzględniać jego osoby w badaniach historycznych. A szkoda, ponieważ znajomość jego dorobku naukowego może dopomóc w lepszym zrozumieniu dziejów Śląska, jak i uświadomienia sobie bogatej spuścizny wielokulturowości, która przez wieki cechowała Ślązaków.
Kanonik Michał Pisarski (1729-1794) w świetle akt czynności Chełmskiej Kapituły Katedralnej obrządku łacińskiego
Authors: Marczewski Jarosław
Published: April 2020

Księgi posiedzeń chełmskiej kapituły katedralnej obrządku łacińskiego stanowią pierwszorzędne źródło do poznania dziejów tej instytucji. Co więcej, znajdują się w nich informacje pozwalające na przybliżenie życia i działalność jej poszczególnych członków. Ks. Michał Pisarski urodził się w 1729 roku w rodzinie szlacheckiej. W młodości wstąpił do zakonu jezuitów, gdzie otrzymał staranną formację i bardzo dobre wykształcenie. W kilku jezuickich szkołach był nauczycielem retoryki, matematyki, filozofii, prawa kanonicznego i teologii. W wyniku kasaty zakonu został zmuszony do przejścia w szeregi duchowieństwa diecezjalnego. Został najpierw kanonikiem w jednej z kolegiat we Lwowie. W 1782 roku wszedł w skład kanoników chełmskiej kapituły katedralnej rezydującej w Krasnymstawie. Był gorliwy w wypełnianiu obowiązków związanych z uzyskaną nominacją. Regularnie uczestniczył w posiedzeniach kapituły, chętnie podejmował dodatkowe zobowiązania. Były mu powierzane odpowiedzialne misje natury administracyjnej i gospodarczej. Wielokrotnie reprezentował interesy kapituły w sytuacjach dotyczących dużych środków kapitałowych. Ks. M. Pisarski był także osobiście dobrodziejem kapituły, wnosząc w ciągu swojego życia znaczący, bo sięgający łącznie 51 000 złp, wkład finansowy w jej utrzymanie. Na podstawie części z tych środków kapituła podjęła zobowiązanie odprawiania co roku liturgii za jego duszę. Ks. M. Pisarski zmarł w 1794 roku. W 2015 roku został zidentyfikowany w zasobach Muzeum 200-lecia Archidiecezji Lubelskiej jego dobrze zachowany portret.
Parafialny kościół farny Świętych Joachima i Anny we Włodzimierzu Wołyńskim w 1831 roku
Authors: Żurek Waldemar Witold
Published: April 2020

Fundatorem obecnego kościoła farnego we Włodzimierzu Wołyńskim był w połowie XVIII wieku tamtejszy rodak, biskup Adam Woyna Orański, sufragan kamieniecki, który konsekrował świątynię. W kościele tym zostali osadzeni karmelici z Zakonu Braci Najświętszej Maryi Panny, popularnie nazywani karmelitami trzewiczkowymi. W samym tylko XIX wieku kościół ten ulegał dwukrotnie (1800, 1833) pożarowi. Dzięki zaangażowaniu tamtejszych pasterzy diecezji, proboszczów i wiernych nie tylko każdorazowo był odbudowywany, lecz także remontowany i modernizowany (1856). Na podstawie powyższego opisu kościoła parafialnego we Włodzimierzu dowiadujemy się o jego historii, odbudowach, wyposażeniu w sprzęt liturgiczny, wystroju oraz o proboszczach. Zamieszcza opis dóbr materialnych przynależnych do parafii, ilość i stan kaplic na terenie parafii.
[Recenzja]: W klasztornym skryptorium. Katalog wystawy, red. Gronowski OSB, Tyniec Wydawnictwo Benedyktynów, Kraków 2018, ss. 50 + nlb
Authors: Kardyś Piotr
Published: April 2020

-
Ks. Idzi Radziszewski 1870-1922 : (w czterdziestą rocznicę śmierci)
Authors: Nowodworski Witold
Published: April 2020

-
Z życia Biblioteki Wyższego Seminarium Duchownego w Lublinie w latach 1957-1963
Authors: Greniuk Franciszek
Published: April 2020

-
Katalog Archiwum Archidiecezjalnego we Wrocławiu : rękopisy
Authors: Urban Wincenty
Published: April 2020

-
Erekcja kolegiaty i kapituły pod wezwaniem Wszystkich Świętych w Bobowej
Authors: Kumor Bolesław
Published: April 2020

-
Katalog Archiwum Archidiecezjalnego we Wrocławiu: (c. d.) : III. Kapituła Katedralna
Authors: Urban Wincenty
Published: April 2020

-
Sprawozdanie z działalności Ośrodka Archiwów, Bibliotek i Muzeów Kościelnych przy KUL za rok 1965
Authors: Hałasa Marian , Łukasiewicz Elżbieta
Published: April 2020

-
Źródła do dziejów Instytutu Księży Komunistów w Polsce znajdujące się w Archiwum Parafialnym w Węgrowie
Authors: Budzisz Marian
Published: April 2020

-
Z zagadnień archiwistyki kościelnej na przykładzie archiwum parafialnego
Authors: Grygier Tadeusz
Published: April 2020

-
Oddział Gromadzenia i Uzupełniania Zbiorów w latach 1944-1970
Authors: Michalski Waldemar
Published: April 2020

-
Rytuał sakry - koronacji królewskiej jako źródło prawa i ustroju państw średniowiecznej Europy
Authors: Sawicki Witold
Published: April 2020

-
Sprawozdanie z działalności Ośrodka Archiwów, Bibliotek i Muzeów Kościelnych przy KUL za rok 1970
Authors: Hałasa Marian , Łukasiewicz Elżbieta
Published: April 2020

-
Bibliografia publikacji pracowników Sekcji Historii na Wydziale Nauk Humanistycznych i Instytutu Geografii Historycznej Kościoła w Polsce Katolickiego Uniwersytetu Lubelskiego z lat 1918-1971
Authors: Ziółek Jan
Published: April 2020

-
Sprawozdanie z działalności Ośrodka Archiwów, Bibliotek i Muzeów Kościelnych przy KUL za rok 1972
Authors: Hałasa Marian , Łukasiewicz Elżbieta
Published: April 2020

-
Biblioteki parafialne a prywatne księgozbiory duchowieństwa: Dekanat Nowa Góra w XVII-XVIII wieku
Authors: Kracik Jan
Published: April 2020

-
Projekt założenia Kolegium Medyczno-Chirurgicznego w Warszawie
Authors: Kumor Bolesław
Published: April 2020

-
Repertorium akt wizytacji kanonicznych dawnej archidiecezji gnieznieńskiej: część 2: akta przechowywane w Archiwum Archidiecezjalnym w Gnieźnie: zeszyt 2: sygnatury 21-50: akta z lat 1775-1820
Authors: Librowski Stanisław
Published: April 2020

-
Źródła do dziejów Seminarium Diecezjalnego w Sandomierzu w latach 1820-1926
Authors: Kotkowski Stanisław
Published: April 2020

-
Kolejny kongres archiwistów kościelnych
Authors: Boguniowski Wacław J.
Published: April 2020

-
Motywy chrześcijańskie w ikonografii monet polskich około 980-1173 r.
Authors: Okunek Marek
Published: April 2020

-
Konsystorz lubelski na przełomie XIX i XX wieku w świetle memoriałów i korespondencji biskupa F. Jaczewskiego
Authors: Stopniak Franciszek
Published: April 2020

-
[Zusammenfassung]: Die Bearbeitung der Sammlungen in den kirchlichen Bibliotheken in Polen - Tagund in Lublin, 18.-19. September 1995
Authors: Ulirch Herbert
Published: April 2020

-
分析核桃病虫害防治策略
Authors: 何 绍书
Published: April 2020

核桃树对于我国多种土壤都广泛适应,并且该树种的寿命相对较长。核桃树属于胡桃科植物,在一些相对比较温暖和干燥的地区,核桃树得到了大量种植。核桃中含有较高含量的亚油酸,可以有效降低人体内的胆固醇,同时核桃中含有的磷脂和蛋白质含量较高,可以对人类大脑发育起到促进作用,其属于一种公认的补脑食物[1]。在我国的几千年历史中,核桃都是餐点食品中比较重要的一种原料,由于核桃的营养价值较高,深受人们喜爱,所以核桃的经济价值也随之增高,因此我国各大地区都开始了核桃种植,而要想进一步促进核桃产业的稳定发展,就需要加强对病虫害的防治,应用科学合理的病虫害防治策略,为核桃种植产量提供进一步保障。
青海林业防沙治沙的对策与措施
Authors: 李 雪萍
Published: April 2020

在实施西部大开发战略中生态环境建设与保护,防沙治沙是我省的重点,是党中央、国务院的重大战略决策。为实现江泽民总书记“再造一个山川秀美的西北地区”的宏伟目标,保证青海省防沙治沙的可持续发展,提出了对策和建议。
探究农业气象灾害对农作物产量的影响
Authors: 雷 雨 , 袁 丽君
Published: April 2020

农业气象灾害是影响农作物产量的重要因素,虽然气象灾害的发生不可避免,但是我们可以根据气象灾害的特点采取相应的防御措施,防患于未然,尽可能的避免农作物的大规模减产。因此,熟悉认知各类气象灾害的特点,增强气象灾害的防范意识,采取应对气象灾害的基础设施建设,对保障农作物产量的具有重要意义。本文主要分析了农业气象灾害的特点,并针对农业气象灾害对农作物产量造成的不良影响提出了一些解决方法,以期减少农业灾害对农作物的影响,促进农业生产的健康发展。
农艺技术在农业生产中的应用
Authors: 陈 艳荣
Published: April 2020

中国是世界上排名靠前的传统农业大国,在我国国内的经济占比中,农业经济占据了重要的地位,做为农业经济发展的根本,农业生产是极其重要的生产活动。随着时代进步和科学技术的快速发展,我国的农艺技术也得到了进一步的提升,在农业生产里也发挥着越来越重要的作用,那么如何将农艺技术合理应用到农业生产中,有效提高农作物的产量,实现最大产量的目标,确保农业生产工作的积极开展,如何把农艺技术深入的提升,满足国家和人民对农作物产量的需要这些疑问都要逐渐提上日程的关键性农业问题。我们针对这些问题来进行分析,探究农业技术在农业生产中的应用和怎样更加完善的应用农业技术进行探讨。
海绵城市理论及其在风景园林规划中的应用
Authors: 潘 颖
Published: April 2020

近年来,生态学获得了快速发展,传统意义上的人与自然的关系逐渐被瓦解,关于新型人与自然关系的理念和方法层出不穷。其中,关于“海绵城市”这一新理念得到了人们的广泛关注。通过“渗、滞、蓄、净、用、排”等措施的综合应用,能够最大限度缓解城市水生态问题。因此,海绵城市建设不仅仅是一个追求建设目标的开发工程项目,而是综合了城市水生态修复、城市水环境改善、城市水安全保障等的生态工程,其建设是对新型城市发展理念的实践,有效推动了城市建设方式的转型。
浅谈水稻集中育秧技术
Authors: 邵 本昌
Published: April 2020

随着全球化进程的不断深入,农业发展全球化已成了衡量一个国家发展的重要因素,我国作为人口大国,粮食刚需量不断提升,如何解决粮食供给问题,是目前农业发展最为迫切需要解决的问题之一。因此,本文将以水稻集中育秧为研究对象,对目前水稻集中育秧相关技术及发展着力点进行分析,并提出相应的提升水稻集中育秧技术的策略,希望帮助相关部门与个人,建立起一套适合自己的集中育秧技术体系,从而有效提升我国水稻产量,解决上述粮食供给问题。
Três anos em perspectiva
Authors: Leão Tarcisio F. , Drigo Evandro
Published: April 2020

Três anos após o primeiro editorial estamos de volta a nossa vocação como sociedade internacional. Foram quatro anos de inatividade da The Academic Society entre a desarticulação internacional (falecimento do secretário do Chile – Pedro Ivo Teixeira de Carvalho Antunes) e a primeira edição da TASJ (2013-2017). Três anos passados, muito crescimento. Que grande satisfação e agradecimento! Em 2017, mudamos a estratégia para aceitar artigos escritos em português visando à divulgação nacional. Ainda neste mesmo ano tivemos o primeiro artigo em inglês, mostrando que estávamos certo na estratégia de origem e que a internacionalização seria retomada. O ano de 2017 finaliza com 3 artigos em inglês. Ao longo das 12 edições, de 2017 a 2019, foram 79 artigos, dos mais complexos e emergentes problemas da sociedade acadêmica nacional e internacional. Foram 59 artigos escritos em português, 19 em inglês e 1 em espanhol. A última edição, V3, n4, foi uma grande conquista, pois tivemos a mesma quantidade de artigos em português e inglês (2 artigos), além do primeiro artigo escrito em espanhol. A inclusão do espanhol como uma das línguas aceitas para publicação surge da integração da TASJ com o Congresso de Engenharia e Ciências Aplicadas nas Três Fronteiras – MEC3F. Um grande acerto de estratégia na integração da nossa região e uma retomada da nossa vocação de integração na América Latina. Muito trabalho foi feito para que a semente de 2012 pudesse germinar. Muito trabalho ainda para que floresça. Muito mais que o trabalho é a vontade de partilhar a evolução do conhecimento. Muito maior é o prazer de fazer isso entre amigos, que não param de aumentar! Estamos felizes e honrados em convidá-los: juntem-se a nós! Estamos de braços abertos.
Nutrient losses of agricultural land due to brick manufacturing in the central region of Bangladesh
Authors: Rahman MK , Eunuch M , Haque GM Fazlul , Khan HR , Rouf AJM Abdur
Published: April 2020

Nutrient losses due to brick production were evaluated at 50 Upazilas in nine districts of the central region of Bangladesh. The average land area occupied by a brick kiln was 0.59 ha. Water‐ extractable N, P, K and S, and total N, P, K and S decreased by 67, 60, 62, 53, 67, 67, 87 and 33% in burnt bricks compared to unburnt one, respectively. Permanent loss of huge quantity of plant nutrients is occurring due to brick manufacturing every year in Bangladesh.

Dhaka Univ. J. Biol. Sci. 24(1): 53-57, 2015 (January)
Influence of gender differences on personality characteristics : A study of urban and rural children
Authors: Sultana Fahema , Pervin Mst Maleka
Published: April 2020

Effects of gender and place of residence on personality characteristics of children were studied. A total of 400 children were the sample of this study of which 200 were from urban and 200 from rural area. Results revealed that male children were more aggressive than female. There was no difference between urban and rural children in aggressiveness vs submissive‐ness. The effects of gender and residence on extroversion vs introversion were not significant. The male children were more relaxed than female children. The effect of residential status on relaxed vs tense was not significant.

Dhaka Univ. J. Biol. Sci. 24(1): 59-64, 2015 (January)
Quantative assesment of kato-katz thick smear and formol-ether concentration technique for the diagnosis of Ascaris lumbricoides
Authors: Khanum Hamida , Alam Mafruha , Khalil Imtiaz , Haque Rashidul
Published: April 2020

The quantitative analysis of A. lumbricoides eggs in stool of 205 subjects (male 101 and female 104) showed that the mean eggs per gram(EPG) by Kato‐ Katz (KK) (EPG = 11130.89) was markedly higher than those of Formal‐Ether concentration technique (FE) (EPG = 1593.32). Co‐efficient of correlation was significant (r = 0.453**) at p = 0.01 level. Age based comparison among the subjects also revealed that KK had a better quantification of A. lumbricoides eggs than FE.

Dhaka Univ. J. Biol. Sci. 24(1): 65-72, 2015 (January)
Prevalence of colour blindness in young Bangladeshis
Authors: Islam Md Shahidul , Roy Proyash , Shehreen Saadlee
Published: April 2020

Abstract not available

Dhaka Univ. J. Biol. Sci. 25(2): 201-205, 2016 (July)
Carriage of multi-drug resistant Gram-negative pathogenic bacteria by the house fly Musca domestica
Authors: Akter Tangin , Ahmed Sangita , Das Badhan Rani
Published: April 2020

Fifteen house flies were used to isolate bacteria from external body surface and alimentary tract. A total of 50 isolates were obtained from the house flies, of which 25 (50%) were collected from the external body surface and 25 (50%) from alimentary gut. Fifteen isolates (30%) were obtained from Shamsunnahar Hall (SN) dining room, 22 (44%) from Dhaka Medical College Hospital (DMCH) and 13 (26%) from Rokeya Hall (RH) canteen. Six Gram-negative bacteria were isolated from the house flies namely, Escherichia coli (36%), Shigella spp. (22%), Salmonella spp. (18%), Pseudomonas spp. (10%), Klebsiella spp. (8%) and Enterobacter spp. (6%). E. coli was the highest in number in all three study areas which was 33% in SN Hall dining, 36% in DMCH, and 39% in RH canteen. E. coli was present in 32 and 40% of external body surface and gut samples, respectively. Bacterial susceptibility to antimicrobial agents showed that E. coli isolates were highly resistant (66-77.7%) to ampicillin, ciprofloxacilin and penicillin antibiotics. Salmonella isolates were sensitive to chloramphenicol but it was (55.5%) resistant to ampicillin, penicillin, tetracycline, gentamycin and imipenem antibiotics. In case of Shigella and Pseudomonas, 72.72 and 80% isolates were resistant to tetracycline and chloramphenicol, respectively. Among the Enterobacter spp. 66.66% were resistant to chloramphenicol, imipenem, vancomycin and tetracycline, while Klebsiella showed 100% resistant pattern to tetracycline in the study. It was observed that house flies carry several multidrug resistant Gram-negative bacteria in their body surface and alimentary tract and played a role in the transmission of serious diseases to human.

Dhaka Univ. J. Biol. Sci. 26(1): 91-99, 2017 (January)
Fungi associated with leaves of Sonneratia apetala Buch. Ham and Sonneratia caseolaris (L.) Engler from Rangabali coastal zone of Bangladesh
Authors: Shamsi Shamim , Hosen Sarowar , Ahmed Ashfaque
Published: April 2020

A total of six species and one genus of fungi associated with black leaf spot of Sonneratia apetala Buch. Ham (Kewra); and anthracnose and small leaf spot of S. caseolaris (L.) Engler (Choila) were isolated following “Tissue planting” method. The fungi associated with black spot of S. apetala were Aspergillus fumigatus Fresenius, Colletotrichum lindemuthianum (Sacc. & Magn.) Br. & Cav., Pestalotiopsis guepinii (Desm.) Stey. and Phoma betae Frank. Anthracnose of S. caseolaris showed the association of A. fumigatus and P. guepinii. The fungi associated with leaf spot of S. caseolaris were Curvularia fallax Boedijn, Fusarium Link, Penicillium digitatum (Pers.) Sacc. and P. betae. Frequency percentage of association of P. guepinii was highest (74.10) in black spot of S. apetala whereas the same fungus showed highest frequency percentage (85.70) in case of anthracnose of S. caseolaris. Phoma betae showed highest frequency percentage (60.00) in leaf spot of S. caseolaris. Phoma betae is first time recorded from Bangladesh.

Dhaka Univ. J. Biol. Sci. 27(2): 155-162, 2018 (July)
Executive functions of people with drug addiction
Authors: Hakeem Marzia Al , Chowdhury Kamal Uddin Ahmed
Published: April 2020

This study aimed to see the impairments of executive functions in people with drug dependence. Participants were selected using a purposive sampling method and the sample size was 120, among them 60 were in drug user group and 60 were healthy control. Neuropsychological assessment tools were used – Frontal Assessment Battery (FAB) and Rey-Osterreith Complex Figure Test (RCFT), for assessing the executive functioning of the participants. Data were analyzed using SPSS software, version 20. Independent-Samples t-test was carried out and the result has shown that the control group performed better in all tests. In FAB, significant difference was found in performance between the drug users and control group, t (90.9) = 9.89, p = 0.00, α = 0.01. Both in copy and immediate recall phase of RCFT, there were significant differences of performance between the drug users and control group, t(70.9) = 8.11, p = 0.00, α = 0.01 and t (118) = 11.9, p = 0.00, α = 0.01, respectively. Results indicate that the executive functions of drug dependent people are significantly impaired. Therefore, this issue should be taken in consideration for creating individualized treatment programs and can also assist in taking preventive measures.

Dhaka Univ. J. Biol. Sci. 29(1): 27-36, 2020 (January)
Searching for humpback whales in a historical whaling hotspot of the Coral Sea, South Pacific
Authors: Garrigue C , Derville S , Bonneville C , Baker CS , Cheeseman T , Millet L , Paton D , Steel D
Published: April 2020

Humpback whalesMegaptera novaeangliaewere severely depleted by commercial whaling. Understanding key factors in their recovery is a crucial step for their conservation worldwide. In Oceania, the Chesterfield-Bellona archipelago was a primary whaling site in the 19thcentury, yet has been left almost unaffected by anthropogenic activities since. We present the results of the first multidisciplinary dedicated surveys in the archipelago assessing humpback whale populations 2 centuries post-whaling. We encountered 57 groups during 24 survey days (2016-2017), among which 35 whales were identified using photographs of natural markings (photo-ID), 38 using genotyping and 22 using both. Humpback whales were sparsely distributed (0.041 whales km-1): most sightings concentrated in shallow inner-reef waters and neighbouring offshore shallow banks. The recently created marine protected area covers most of the areas of high predicted habitat suitability and high residence time from satellite-tracked whales. Surprisingly for a breeding area, sex ratios skewed towards females (1:2.4), and 45% of females were with calf. Connectivity was established with the New Caledonia breeding area to the east (mtDNAFST= 0.001, p > 0.05, 12 photo-ID and 10 genotype matches) and with the Australian Great Barrier Reef breeding area to the west (mtDNAFST= 0.006, p > 0.05). Movement of satellite-tracked whales and photo-ID matches also suggest connections with the east Australian migratory corridor. This study confirms that humpback whales still inhabit the Chesterfield-Bellona archipelago 2 centuries post whaling, and that this pristine area potentially plays a role in facilitating migratory interchange among breeding grounds of the western South Pacific.
PERLINDUNGAN PASIEN DALAM PELAYANAN KESEHATAN OLEH FASILITAS KESEHATAN BPJS DI KOTA BANDUNG DIHUBUNGKAN DENGAN UNDANG-UNDANG NO. 24 TAHUN 2011 TENTANG BADAN PENYELENGGARA JAMINAN SOSIAL DAN PERATURAN MENTERI KESEHATAN NO. 71 TAHUN 2013 TENTANG PELAYANAN KESEHATAN PADA JAMINAN KESEHATAN NASIONAL
Authors: Sholehah Balqis Mar’atus , Sudjana U. , Suryaman Aam
Published: April 2020

Kesejahteraan sosial merupakan bangunan dasar bagi setiap negara dalam membangun dan memberikan perlindungan kepada segenap bangsanya. Salah satu unsur kesejahteraan umum sekaligus hak asasi manusia yang harus diwujudkan sesuai dengan cita-cita bangsa Indonesia yaitu kesehatan. Badan Penyelenggara Jaminan Sosial (BPJS) Kesehatan merupakan badan hukum publik dibentuk dengan Undang-Undang untuk menyelenggarakan program jaminan sosial nasional. Faktanya dalam pemberian pelayanan kesehatan oleh salah satu fasilitas kesehatan yang berada di Kota Bandung yaitu Rumah Sakit, masih terdapat pasien peserta BPJS yang belum terpenuhi haknya untuk mendapatkan pelayanan kesehatan yang optimal. Permasalahan yang sering terjadi yaitu kelangkaan obat yang telah dijamin dalam Daftar Obat Esensial (DOEN) serta keterlambatan pelayanan kesehatan oleh petugas kesehatan di salah satu Rumah Sakit X di Kota Bandung. Penelitian ini bertujuan untuk mendapatkan gambaran tentang pemberian pelayanan kesehatan oleh fasilitas kesehatan yang bekerjasama dengan BPJS dan perlindungan terhadap pasien peserta BPJS Kesehatan. Penelitian ini disusun dengan menggunakan metode pendekatan yuridis normatif yaitu metode penelitian yang difokuskan untuk mengkaji penerapan kaidah-kaidah atau norma-norma dalam hukum positif yang kemudian dianalisis secara normatif kualitatif. Hasil penelitian dapat disimpulkan bahwa pemberian pelayanan kesehatan terhadap pasien peserta BPJS di rumah sakit dan puskesmas belum sepenuhnya memadai, hal ini dapat dilihat dari tidak terpenuhnya hak yang dimiliki pasien untuk medapatkan obat dan pelayanan kesehatan sesuai dengan kebutuhan pasien, sesuai dengan Pasal 13 UU BPJS memiliki kewajiban memberikan manfaat kepada seluruh peserta untuk mendapatkan hak dan memenuhi kewajibannya, serta Permenkes No.71 Tahun 2013 Pasal 13 ayat 1 bahwa manfaat jaminan kesehatan, mencakup pelayanan promotif, preventif, kuratif, dan rehabilitatif, termasuk pelayanan obat, alat kesehatan, dan bahan medis habis pakai. Hal ini Rumah Sakit bertanggung jawab atas kerugian yang ditimbulkan akibat pelayanan kesehatan yang diberikan oleh petugas kesehatan terhadap pasien peserta BPJS.
PELAKSANAAN DIVERSI DALAM PERKARA ANAK PADA TINGKAT PEMERIKSAAN PENGADILAN
Authors: Waluyadi Waluyadi
Published: April 2020

Penyelesaian kasus pidana anak,  wajib mengutamakan pendekatan Keadilan Restoratif, yaitu penyelesaian perkara pidana dengan melibatkan pelaku, korban, keluarga pelaku/korban, dan pihak lain  yang terkait untuk bersama-sama mencari penyelesaian yang adil dengan menekankan pemulihan kembali pada keadaan semula. Penerapan pendekatan Restoratif Justice dalam perkara anak, diwujudkan dalam bentuk diversi. Permasahan yang muncul adalah bagaimanakah kebijakan prosedural  dalam pelaksanaan Diversi dan realitas praktiknya di tingkat pemeriksaan pengadilan. Dalam penelitian ini menggunakan paradigma positivistik. Hukum.  Data yang digunakan data sekunder. Pengumpulan data dilakukan dengan studi pustaka. Analisisnya menggunakan  analisis kualitatif dengan model interaktif. Kebijakan prosedural dalam pelaksanaan diversi pada tingkat pemeriksaan Pengadilan berpedoman pada UU No. 12 Tahun 2011 dan pada Peraturan Mahkamah Agung No. 4 Tahun 2014. . Dalam praktik di lapangan, terdapat kendala tidak dapat  dilakukanya Diversi karena terkendala oleh persyaratan yang kaku sebagaimana tersebut pada pasal 7 ayat  (2) huruf a. Undang-Undang No. 12 Tahun 2011.
Teaching Music Composition: A Poetic Interdisciplinary Path Through Art and Life
Authors: Yampolschi Roseane
Published: April 2020

In this essay I introduce some ideas and experiences that have been the object of numerous studies and resource materials for composition for several years. This whole information has to do, firstly, with an interdisciplinary context of studies and music creation that refers back to my doctoral thesis; secondly, with research and creative experiences based on the musical gesture and that one under the perspective of "enactment" ; and thirdly, with a poetic view of the sonorous architecture of the artistic work from an intrinsic relation between sound and silence.
Recalibrating Veterinary Medicine through Animal Welfare Science and Ethics for the 2020s
Authors: De Paula Vieira Andreia , Anthony Raymond
Published: April 2020

What should leading discourses and innovation regarding animal welfare look like for the veterinary profession in the 2020s? This essay considers four main challenges into which veterinarians are increasingly being drawn, as they respond to increasing public expectation for them to be scientific and moral authorities in animal welfare in addition to their traditional role as trusted health experts. They include: (1) to go beyond traditional conceptions of health by adopting a holistic view that also considers animal welfare, not only disease treatment; (2) to reimagine their professional duties when it comes to disease prevention at the intersection of animal-human-ecosystem health; (3) to develop core competencies/proficiency in animal welfare science and ethics in order to navigate discourses concerning competing priorities and socio-political ideologies and to provide professional leadership in animal welfare; (4) to provide feedback on novel networked devices, monitoring technologies and automated animal welfare solutions and their impact on animals’ welfare. To competently navigate the intricacies of the socio-political and connected world as trusted authorities and conduits for innovation in and through animal welfare, veterinarians and veterinary students are encouraged to: (a) develop core competencies in veterinary ethics, animal welfare science and deliberative capacities that are well-informed by current multidisciplinary frameworks, such as One Health; (b) engage interested parties in more effective collaboration and ethical decision-making in order to address animal welfare related concerns within their immediate sphere of influence (e.g., in a given community); and (c) participate in the process of engineering and technological design that incorporates animals’ welfare data (such as their preferences) for real-time animal monitoring through adding animal scientific and values-aware evidence in information technology systems. In order to tackle these challenges, four pillars are suggested to help guide veterinarians and the veterinary profession. They are: Collaboration, Critical Engagement, Centeredness on Research, and Continuous Self-Critique.
Polyketide-Derived Secondary Metabolites from a Dothideomycetes Fungus, Pseudopalawania siamensis gen. et sp. nov., (Muyocopronales) with Antimicrobial and Cytotoxic Activities
Authors: Mapook Ausana , Macabeo Allan Patrick G. , Thongbai Benjarong , Hyde Kevin D. , Stadler Marc
Published: April 2020

Pseudopalawania siamensis gen. et sp. nov., from northern Thailand, is introduced based on multi-gene analyses and morphological comparison. An isolate was fermented in yeast malt culture broth and explored for its secondary metabolite production. Chromatographic purification of the crude ethyl acetate (broth) extract yielded four tetrahydroxanthones comprised of a new heterodimeric bistetrahydroxanthone, pseudopalawanone (1), two known dimeric derivatives, 4,4′-secalonic acid D (2) and penicillixanthone A (3), the corresponding monomeric tetrahydroxanthone paecilin B (4), and the known benzophenone, cephalanone F (5). Compounds 1–3 showed potent inhibitory activity against Gram-positive bacteria. Compounds 2 and 3 were inhibitory against Bacillus subtilis with minimum inhibitory concentrations (MIC) of 1.0 and 4.2 μg/mL, respectively. Only compound 2 showed activity against Mycobacterium smegmatis. In addition, the dimeric compounds 1–3 also showed moderate cytotoxic effects on HeLa and mouse fibroblast cell lines, which makes them less attractive as candidates for development of selectively acting antibiotics.
Human PCNA Structure, Function and Interactions
Authors: González-Magaña Amaia , Blanco Francisco J.
Published: April 2020

Proliferating cell nuclear antigen (PCNA) is an essential factor in DNA replication and repair. It forms a homotrimeric ring that embraces the DNA and slides along it, anchoring DNA polymerases and other DNA editing enzymes. It also interacts with regulatory proteins through a sequence motif known as PCNA Interacting Protein box (PIP-box). We here review the latest contributions to knowledge regarding the structure-function relationships in human PCNA, particularly the mechanism of sliding, and of the molecular recognition of canonical and non-canonical PIP motifs. The unique binding mode of the oncogene p15 is described in detail, and the implications of the recently discovered structure of PCNA bound to polymerase δ are discussed. The study of the post-translational modifications of PCNA and its partners may yield therapeutic opportunities in cancer treatment, in addition to illuminating the way PCNA coordinates the dynamic exchange of its many partners in DNA replication and repair.
Kynurenic Acid Levels are Increased in the CSF of Alzheimer’s Disease Patients
Authors: González-Sánchez Marta , Jiménez Javier , Narváez Arantzazu , Antequera Desiree , Llamas-Velasco Sara , Martín Alejandro Herrero-San , Molina Arjona Jose Antonio , López de Munain Adolfo , Lleó Bisa Alberto , Marco M.-Pilar , Rodríguez-Núñez Montserrat , Pérez-Martínez David Andrés , Villarejo-Galende Alberto , Bartolome Fernando , Domínguez Elena , Carro Eva
Published: April 2020

Kynurenic acid (KYNA) is a product of the tryptophan (TRP) metabolism via the kynurenine pathway (KP). This pathway is activated in neurodegenerative disorders, such as Alzheimer´s disease (AD). KYNA is primarily produced by astrocytes and is considered neuroprotective. Thus, altered KYNA levels may suggest an inflammatory response. Very recently, significant increases in KYNA levels were reported in cerebrospinal fluid (CSF) from AD patients compared with normal controls. In this study, we assessed the accuracy of KYNA in CSF for the classification of patients with AD, cognitively healthy controls, and patients with a variety of other neurodegenerative diseases, including frontotemporal dementia (FTD), amyotrophic lateral sclerosis (ALS), and progressive supranuclear palsy (PSP). Averaged KYNA concentration in CSF was higher in patients with AD when compared with healthy subjects and with all the other differentially diagnosed groups. There were no significant differences in KYNA levels in CSF between any other neurodegenerative groups and controls. These results suggest a specific increase in KYNA concentration in CSF from AD patients not seen in other neurodegenerative diseases.
Multidirectional Changes in Parameters Related to Sulfur Metabolism in Frog Tissues Exposed to Heavy Metal-Related Stress
Authors: Kaczor-Kamińska Marta , Sura Piotr , Wróbel Maria
Published: April 2020

The investigations showed changes of the cystathionine γ-lyase (CTH), 3-mercaptopyruvate sulfurtransferase (MPST) and rhodanese (TST) activity and gene expression in the brain, heart, liver, kidney, skeletal muscles and testes in frogs Pelophylax ridibundus, Xenopus laevis and Xenopus tropicalis in response to Pb2+, Hg2+ and Cd2+ stress. The results were analyzed jointly with changes in the expression of selected antioxidant enzymes (cytoplasmic and mitochondrial superoxide dismutase, glutathione peroxidase, catalase and thioredoxin reducatase) and with the level of malondialdehyde (a product of lipid peroxidation). The obtained results allowed for confirming the role of sulfurtransferases in the antioxidant protection of tissues exposed to heavy metal ions. Our results revealed different transcriptional responses of the investigated tissues to each of the examined heavy metals. The CTH, MPST and TST genes might be regarded as heavy metal stress-responsive. The CTH gene expression up-regulation was confirmed in the liver (Pb2+, Hg2+, Cd2+) and skeletal muscle (Hg2+), MPST in the brain (Pb2+, Hg2+), kidney (Pb2+, Cd2+), skeletal muscle (Pb2+, Hg2+,Cd2+) and TST in the brain (Pb2+) and kidney (Pb2+, Hg2+, Cd2+). Lead, mercury and cadmium toxicity was demonstrated to affect the glutathione (GSH) and cysteine levels, the concentration ratio of reduced to oxidized glutathione ([GSH]/[GSSG]) and the level of sulfane sulfur-containing compounds, which in case of enhanced reactive oxygen species generation can reveal their antioxidative properties. The present report is the first to widely describe the role of the sulfane sulfur/H2S generating enzymes and the cysteine/glutathione system in Pb2+, Hg2+ and Cd2+ stress in various frog tissues, and to explore the mechanisms mediating heavy metal-related stress.
Inhibition of Kv10.1 Channels Sensitizes Mitochondria of Cancer Cells to Antimetabolic Agents
Authors: Hernández-Reséndiz Ileana , Pacheu-Grau David , Sánchez Araceli , Pardo Luis A.
Published: April 2020

Reprogramming of energy metabolism constitutes one of the hallmarks of cancer and is, therefore, an emerging therapeutic target. We describe here that the potassium channel Kv10.1, which is frequently overexpressed in primary and metastatic cancer, and has been proposed a therapeutic target, participates in metabolic adaptation of cancer cells through regulation of mitochondrial dynamics. We used biochemical and cell biological techniques, live cell imaging and high-resolution microscopy, among other approaches, to study the impact of Kv10.1 on the regulation of mitochondrial stability. Inhibition of Kv10.1 expression or function led to mitochondrial fragmentation, increase in reactive oxygen species and increased autophagy. Cells with endogenous overexpression of Kv10.1 were also more sensitive to mitochondrial metabolism inhibitors than cells with low expression, indicating that they are more dependent on mitochondrial function. Consistently, a combined therapy using functional monoclonal antibodies for Kv10.1 and mitochondrial metabolism inhibitors resulted in enhanced efficacy of the inhibitors. Our data reveal a new mechanism regulated by Kv10.1 in cancer and a novel strategy to overcome drug resistance in cancers with a high expression of Kv10.1.