bluuebunny/crossref_metadata_2025 huggingface dataset:
Design, Synthesis, and Anti-Breast Cancer Activity of Novel Fluorinated
7-O-Modified Genistein Derivatives
Authors: Xiang Yijun , Yao Xu , Zheng Xing , Yang Zhifang , Liu Yi , Liu Zhuo , Xu Qinfang , Liu Shun , Jiang Kailin , Shi Yuanlong , Xu Wenyu , Yang Zehua , Mi Pengbing
Published: June 2022

Background:

Genistein has been limited in clinical application due to its low bioavailability, extremely poor liposolubility, and fast glycosylation rate, though it possesses anti-breast cancer activity. Therefore, the discovery of novel genistein derivatives is an urgency.

Objective:

To enhance the anti-breast cancer activity of genistein, a series of novel fluorinated genistein derivatives were synthesized.

Method:

Their in vitro antitumor activity was investigated by the MTT assay against three cancer cell lines, via., MDA-MB-231, MCF-7 and MDA-MB-435, respectively.

Results:

Analogs 1d, 2b, 3b showed remarkable anticancer activities comparing to tamoxifen, a clinical anti-breast cancer drug on the market.

Conclusion:

The activities against breast cancer of genistein were enhanced by introducing 7-alkoxyl group and fluorine atom into the B-ring. Therefore, these compounds may be potential candidates for treating breast cancer.
Surface-Enhanced Raman Scattering: A Promising Nanotechnology for
Anti-Counterfeiting and Tracking Systems
Authors: Alkhuder Khaled
Published: June 2022

Surface-enhanced Raman Scattering (SERS) is a sensing method based on inelastic
scattering of a laser beam by a reporter molecule absorbed on a plasmonic substrate. The incident
laser beam induces a localized-surface plasmon resonance in the substrate, which generates an
oscillating electromagnetic field on the substrate dielectric surface. Under the influence of this
field, the reporter molecule absorbed on the plasmonic substrate starts to vibrate, causing inelastic
scattering of the laser beam. The laser-induced electromagnetic field is also the main contributor
to the enhancement observed in the intensity of the scattered light. Plasmonic substrates are
nanostructured surfaces often made of noble metals. The surface enhancement of a plasmonic
substrate is determined primarily by factors related to the substrate’s nano-architecture and its
composition. SERS-based labeling has emerged as a reliable and sophisticated anti-counterfeiting
technology with potential applications in a wide range of industries. This technology is based on
detecting the SERS signals produced by SERS tags using Raman spectroscopy. SERS tags are
generally made of a plasmonic substrate, a Raman reporter, and a protective coating shell. They
can be engineered using a wide variety of materials and methods. Several SERS-based anticounterfeiting
labels have been developed in the past two decades. Some of these labels have
been successfully combined with identification systems based on artificial intelligence. The purpose
of this review is to shed light on the SERS technology and the progress that has been
achieved in the SERS-based tracking systems.
Synthesis, Characterization, and Pharmacological Activities of Copper(II)
Complexes of Curcumin Derivatives
Authors: Kothari Richa , Agrawal Anurag
Published: June 2022

Background:

Curcuma longa L is a herbaceous plant of zingiberaceae family. Curcumin and its derivatives possess a vast varieties of biological activities like antimicrobial, antioxidant, anti-inflammatory, antimalarial, antirheumatic etc. Looking into the biological significance of curcumin and its derivatives, we have decided to synthesize novel derivatives of curcumin and their coordinated Copper (II) complexes and evaluate their pharmacological activities like antioxidant, antibacterial etc.

Methods:

Targeted derivatives of curcumin were prepared in good yield (95%) by the condensation reaction of carbohydrazide(1), Curcumin(2), in presence of copper salts using classical heating methods in the presence of absolute ethanol.

Results:

The targeted derivatives of Curcumin were evaluated for their collaborative antimicrobial activity against gram-positive and gram-negative bacterial strains. The zone of inhibition was measured by considering the disc diffusion method. In-vitro minimum inhibitory concentrations of targeted compounds were measured using the broth micro-dilution method. In addition to this, the invitro antioxidant activity of target compounds was also evaluated by adopting the DPPH method using ascorbic acid as a standard substance. Most of the compounds showed fascinating antibacterial and antioxidant activities as a contrast to pure curcumin.

Conclusion:

In conclusion, the present work explains the synthesis, characterization and evaluation of biological activities of novel derivatives of curcumin and their coordinated Copper (II) complexes. All the targeted compounds were screened for their pharmacological evaluation against selected human pathogenic bacteria. Antioxidant activity of the synthesized compounds was also evaluated against DPPH and ascorbic acid standard substances. Among the designed molecules, most of the compounds showed fascinating antibacterial and antioxidant activities as compared to pure curcumin.
FAMILIA COMPOSITAE: TRIBU CARDUEAE
Authors:   Colegio de Postgraduados-Campus Tabasco, García López Eustolia , Koch Stephen D. ,   Programa de Botánica Instituto de Recursos Naturales Colegio de Postgraduados
Published: June 2022

Familia muy vasta, de alrededor de 1000 géneros y unas 20000 especies, de distribución cosmopolita. Se encuentra particularmente bien representada en nuestro país, donde constituye cerca de 15% de la flora vascular, concentrándose su diversidad en regiones de clima seco a semihúmedo y sobre todo en la vegetación secundaria. Las Compositae (o Asteraceae) incluyen algunas especies de mayor interés económico, como el cártamo (Carthamus tinctorius L.) y el girasol (Helianthus annuus L.), ambas de creciente importancia como plantas oleaginosas, la lechuga (Lactuca sativa L.) y otras. De las numerosas que se cultivan como ornamentales, no pocas son de origen mexicano, como el cempasúchil (Tagetes), la dalia (Dahlia) y el mirasol (Cosmos). Muchas, como la manzanilla (Matricaria), el gordolobo (Gnaphalium) y el estafiate (Artemisia) son de importancia medicinal. Cerca de 400 especies mexicanas de esta familia se comportan como malezas ruderales y arvenses. La tribu, también conocida bajo el nombre de Cynareae, está constituida por 83 géneros y unas 2500 especies, distribuidas principalmente en el norte de África y Eurasia, algunos géneros se extienden a Norteamérica, África tropical y en el Hemisferio Sur, a Australia y Sudamérica. Sus integrantes tienen importancia ecológica en bosques y comunidades secundarias; algunas de sus especies se cultivan como ornamentales, tal es el caso de varias especies de Centaurea, a otras se les atribuyen propiedades medicinales (Cirsium ehrenbergii) o alimenticias (Carthamus tinctorius y Cynara scolymus) y muchas se comportan como malezas (incluyendo varias especies de Cirsium).
FAMILIA COMPOSITAE: TRIBU VERNONIEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Rzedowski Jerzy , Calderón de Rzedowski Graciela ,   Instituto de Ecología, A.C. Centro Regional del Bajío
Published: June 2022

El grupo comprende alrededor de 70 géneros y unas 1500 especies, de las que cerca de mil corresponden a Vernonia. En su gran mayoría son de distribución tropical y de relativamente escaso interés económico. En la región de estudio representado por cuatro géneros.
FAMILIA VITTARIACEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Palacios-Rios Autores/as Mónica
Published: June 2022

Familia filogenéticamente algo aislada, constituida por un grupo muy natural de helechos leptosporangiados, bien adaptados al hábito epifítico y con estructuras notablemente simplificadas. Comprende seis géneros y alrededor de 100 especies distribuidas en las regiones de clima cálido del Globo. Algunos autores consideran a este grupo como subfamilia de Adiantaceae. El único género que se encuentra representado en la región de esta Flora es Vittaria, que destaca por su hábito epifítico, en combinación con escamas del rizoma clatradas, así como hojas simples, enteras y colgantes.
FAMILIA CECROPIACEAE
Authors:   Herbario del Instituto de Botánica Universidad de Guadalajara, Carvajal Servando , Peña-Pinela Cruz ,   Herbario del Instituto de Botánica Universidad de Guadalajara
Published: June 2022

Familia de distribución pantropical que comprende seis géneros y 180 a 200 especies; en nuestra área de estudio con un solo representante. Los miembros de Cecropiaceae tradicionalmente se incluían en Moraceae y por algunos autores en Urticaceae, pero en ambas familias constituían elementos discordantes a causa de diversos caracteres. En consecuencia, la propuesta de Berg (1978) de colocarlos en una familia independiente parece ser la decisión más acertada. De este modo pueden explicarse de manera más natural sus relaciones intergenéricas y su filogenia.
FAMILIA COMPOSITAE: TRIBU LACTUCEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Calderón de Rzedowski Graciela
Published: June 2022

Esta tribu, conocida anteriormente como Cichorieae, incluye alrededor de 70 géneros y 2300 especies ampliamente distribuidas, sobre todo en las zonas templadas del Hemisferio Norte. Muchas de las que habitan en México son adventicias del Viejo Mundo. Algunos de sus representantes tienen importancia económica desde el punto de vista alimenticio, como el "salsifí" (Tragopogon parvifolius L.) o la "achicoria" (Cichorium intybus L.), que se usa también como adulterante del café. Es asimismo notable la "lechuga" (Lactuca sativa L.) que independientemente de ser comestible, se usa como medicamento. Varias viven en lugares en disturbio o se comportan como malezas.
FAMILIA CROSSOSOMATACEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Calderón de Rzedowski Graciela
Published: June 2022

La familia comprende cuatro géneros con unas 12 especies, distribuidas desde el oeste y suroeste de Estados Unidos hasta el centro de México.
FAMILIA KOEBERLINIACEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Calderón de Rzedowski Graciela
Published: June 2022

Familia que comprende un solo género distribuido en regiones secas desde el suroeste de Estados Unidos hasta el centro de México, en forma discontinua se conoce también de una región semiárida de Bolivia. Algunos autores incluyeron a Canotia en las Koeberliniaceae, pero más recientemente se vio que tal género queda mejor colocado en Celastraceae. Por otro lado, es frecuente asimismo la ubicación de Koeberlinia en Capparidaceae. En esta contribución se sigue a Standley (op. cit.), así como a Correll y Johnston (op. cit.), quienes prefiren considerarla en una familia independiente.
FAMILIA CAMPANULACEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Rzedowski Jerzy , Calderón de Rzedowski Graciela ,   Instituto de Ecología, A.C. Centro Regional del Bajío
Published: June 2022

Se calculan unos 60 a 65 géneros y unas 1000 a 1500 especies ampliamente distribuidas por todos los continentes, pero sobre todo en regiones templadas o subtropicales. Algunos de sus representantes (principalmente de Campanula y Lobelia) se cultivan como ornamentales. En la zona de estudio se reconocen cuatro géneros.
FAMILIA BASELLACEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Calderón de Rzedowski Graciela
Published: June 2022

Comprende cuatro géneros con alrededor de 20 especies, en su mayoría de zonas tropicales y subtropicales de América, sobre todo de su parte sur, aunque Basella es nativa del Viejo Mundo. Las Basellaceae han sido relacionadas y confundidas por diferentes autores con varias familias dentro del orden Centrospermae, pero en apariencia el grupo filogenéticamente más cercano lo constituyen las Portulacaceae. Varios de sus representantes se cultivan por ser de interés económico desde el punto de vista alimenticio. Este es el caso de Ullucus tuberosus Cald. ("papa lisa", "ullucu"), apreciado por sus tubérculos comestibles en la región andina, y de Basella alba L. ("espinaca de China"), que se consume como verdura en muchos países de Asia y de África. Algunas especies se estiman asimismo como ornamentales o medicinales. De la región de estudio sólo se conoce un género.
FAMILIA COMPOSITAE: TRIBU ANTHEMIDEAE
Authors:   Instituto de Ecología, A.C. Centro Regional del Bajío, Rzedowski Jerzy , Calderón de Rzedowski Graciela ,   Instituto de Ecología, A.C. Centro Regional del Bajío
Published: June 2022

Se calculan alrededor de 100 géneros con unas 1500 especies, principalmente de regiones de clima templado o frío del Hemisferio Norte. Algunas se cultivan como plantas de ornato, como las "margaritas" o "crisantemos" (Chrysanthemum spp.), o bien por ser de uso medicinal, como la "manzanilla" (Matricaria recutita L.) y la "milenrama" (Achillea millefolium). A esta tribu pertenecen varias especies de Tanacetum que contienen el principio activo llamado piretrina de propiedades insecticidas. Ciertas Anthemideae se utilizan como condimento, otras son malezas. En la región de estudio se reconocen seis géneros y diez especies, en su mayoría adventicias.
Improving the Engine Efficiency Using a New Combined Refrigeration Cycle for Low-Temperature Heat Source (Waste Heat Recovery)
Authors:   Yasouj University, Yasouj 75918-74831, Iran, Goudarzi Koorosh , Zare Mohammad Reza ,   Yasouj University, Yasouj 75918-74831, Iran
Published: June 2022

Passenger and commercial internal combustion engines have relatively large dissipated thermal energy sources that can be used for initiating thermodynamic refrigeration cycles at low temperatures while improving engine efficiency. Researchers have focused on combined power-refrigeration cycles in past studies. This paper presents the operation and performance of a new combined refrigeration system driven by waste heat recovery within the internal combustion engines. For this purpose, the effects of several parameters on the performance of the cycle are examined. Results show that an increase in the engine water temperature, exhaust gas temperature, part-load ratio (PLR), generator temperature, as well as adsorption evaporator temperature had a positive effect on the performance of the cycle. However, the rise in condenser temperature of the adsorption cooling system leads to bad performance. Also, the results indicate that the application of the adsorption refrigeration cycle in the combined cooling cycle, along with the increase in the refrigeration cycle performance by up to 65%, also improves the efficiency of the internal combustion engine.
eHealth Literacy and its Associated Factors Among Health Professionals During the COVID-19 Pandemic in Resource-Limited Settings: Cross-sectional Study
Authors: Tesfa Getanew Aschalew , Yehualashet Delelegn Emwodew , Ewune Helen Ali , Zemeskel Addisu Getnet , Kalayou Mulugeta Hayelom , Seboka Binyam Tariku
Published: June 2022

Background

The COVID-19 pandemic has wreaked havoc on health care systems and governments worldwide. Although eHealth literacy is acknowledged as a critical component of public health, it was overlooked during the pandemic. To assist patients and their families, health professionals should be knowledgeable about online health information resources and capable of evaluating relevant online information. In a resource-constrained situation, the level of eHealth literacy among health professionals is not well documented.

Objective

The aim of this study was to assess the eHealth literacy level and its associated factors among health professionals working in Amhara regional state teaching hospitals, Ethiopia.

Methods

A self-administered questionnaire was used in an institutional-based cross-sectional study design. Descriptive statistics were calculated to describe eHealth literacy statements and key variables using SPSS v.24. Bivariable and multivariable logistic regression models were fit to identify factors related to eHealth literacy. Variables with P<.05 were declared to be statistically significant predictors.

Results

A total of 383 participants completed and returned the questionnaire with a response rate of 90.5%. Health professionals demonstrated a moderate level of eHealth literacy (mean 29.21). Most of the professionals were aware of the available health resources located on the internet, and know how to search and locate these resources. However, they lack the ability to distinguish high-quality health resources from low-quality resources. Factors that were significantly associated with eHealth literacy were computer access, computer knowledge, perceived ease of use, and perceived usefulness of eHealth information resources.

Conclusions

It is crucial to provide training and support to health care workers on how to find, interpret, and, most importantly, evaluate the quality of health information found on the internet to improve their eHealth literacy level. Further research is needed to explore the role of eHealth literacy in mitigating pandemics in developing countries.
Investigating Microtemporal Processes Underlying Health Behavior Adoption and Maintenance: Protocol for an Intensive Longitudinal Observational Study
Authors: Wang Shirlene , Intille Stephen , Ponnada Aditya , Do Bridgette , Rothman Alexander , Dunton Genevieve
Published: June 2022

Background

Young adulthood (ages 18-29 years) is marked by substantial weight gain, leading to increased lifetime risks of chronic diseases. Engaging in sufficient levels of physical activity and sleep, and limiting sedentary time are important contributors to the prevention of weight gain. Dual-process models of decision-making and behavior that delineate reflective (ie, deliberative, slow) and reactive (ie, automatic, fast) processes shed light on different mechanisms underlying the adoption versus maintenance of these energy-balance behaviors. However, reflective and reactive processes may unfold at different time scales and vary across people.

Objective

This paper describes the study design, recruitment, and data collection procedures for the Temporal Influences on Movement and Exercise (TIME) study, a 12-month intensive longitudinal data collection study to examine real-time microtemporal influences underlying the adoption and maintenance of physical activity, sedentary behavior, and sleep.

Methods

Intermittent ecological momentary assessment (eg, intentions, self-control) and continuous, sensor-based passive monitoring (eg, location, phone/app use, activity levels) occur using smartwatches and smartphones. Data analyses will combine idiographic (person-specific, data-driven) and nomothetic (generalizable, theory-driven) approaches to build models that may predict within-subject variation in the likelihood of behavior “episodes” (eg, ≥10 minutes of physical activity, ≥120 minutes of sedentary time, ≥7 hours sleep) and “lapses” (ie, not attaining recommended levels for ≥7 days) as a function of reflective and reactive factors.

Results

The study recruited young adults across the United States (N=246). Rolling recruitment began in March 2020 and ended August 2021. Data collection will continue until August 2022.

Conclusions

Results from the TIME study will be used to build more predictive health behavior theories, and inform personalized behavior interventions to reduce obesity and improve public health.

International Registered Report Identifier (IRRID)

DERR1-10.2196/36666
Methodologies Used to Study the Feasibility, Usability, Efficacy, and Effectiveness of Social Robots For Elderly Adults: Scoping Review
Authors: Mahmoudi Asl Aysan , Molinari Ulate Mauricio , Franco Martin Manuel , van der Roest Henriëtte
Published: June 2022

Background

New research fields to design social robots for older people are emerging. By providing support with communication and social interaction, these robots aim to increase quality of life. Because of the decline in functioning due to cognitive impairment in older people, social robots are regarded as promising, especially for people with dementia. Although study outcomes are hopeful, the quality of studies on the effectiveness of social robots for the elderly is still low due to many methodological limitations.

Objective

We aimed to review the methodologies used thus far in studies evaluating the feasibility, usability, efficacy, and effectiveness of social robots in clinical and social settings for elderly people, including persons with dementia.

Methods

Dedicated search strings were developed. Searches in MEDLINE (PubMed), Web of Science, PsycInfo, and CINAHL were performed on August 13, 2020.

Results

In the 33 included papers, 23 different social robots were investigated for their feasibility, usability, efficacy, and effectiveness. A total of 8 (24.2%) studies included elderly persons in the community, 9 (27.3%) included long-term care facility residents, and 16 (48.5%) included people with dementia. Most of the studies had a single aim, of which 7 (21.2%) focused on efficacy and 7 (21.2%) focused on effectiveness. Moreover, forms of randomized controlled trials were the most applied designs. Feasibility and usability were often studied together in mixed methods or experimental designs and were most often studied in individual interventions. Feasibility was often assessed with the Unified Theory of the Acceptance and Use of Technology model. Efficacy and effectiveness studies used a range of psychosocial and cognitive outcome measures. However, the included studies failed to find significant improvements in quality of life, depression, and cognition.

Conclusions

This study identified several shortcomings in methodologies used to evaluate social robots, resulting in ambivalent study findings. To improve the quality of these types of studies, efficacy/effectiveness studies will benefit from appropriate randomized controlled trial designs with large sample sizes and individual intervention sessions. Experimental designs might work best for feasibility and usability studies. For each of the 3 goals (efficacy/effectiveness, feasibility, and usability) we also recommend a mixed method of data collection. Multiple interaction sessions running for at least 1 month might aid researchers in drawing significant results and prove the real long-term impact of social robots.
Tuberculosis Treatment Compliance Under Smartphone-Based Video-Observed Therapy Versus Community-Based Directly Observed Therapy: Protocol for a Cluster Randomized Controlled Trial
Authors: Kumwichar Ponlagrit , Chongsuvivatwong Virasakdi , Prappre Tagoon
Published: June 2022

Background

The health care system in Thailand has struggled to cope with the COVID-19 pandemic, resulting in decreased administration of community-based directly observed therapy (DOT) for tuberculosis (TB). As an alternative to failed DOT, video-observed therapy (VOT) or the Thai asynchronous VOT system, “TH VOT,” was devised. We developed a protocol for a study to test the superiority of VOT over DOT in ensuring treatment compliance.

Objective

We aim to compare the mean cumulative compliance days of TB patients and their observers under the VOT program with that of individuals under the DOT program during the intensive phase of TB treatment.

Methods

A cluster randomized controlled trial of pulmonary TB patients and their observers will be conducted over a 2-month period. This study will be conducted in the Hat Yai and Meuang Songkhla districts of Songkhla Province, Southern Thailand. A total of 38 observers working at 38 primary care units (PCUs) will be randomized equally into VOT and DOT groups. The TH VOT system will be implemented in 19 PCUs in the VOT group while the other 19 PCUs will continue with the traditional DOT program. Approximately 1-5 TB patients will be under observation, depending on the PCU jurisdiction in which the patients reside. The inclusion criteria for TB patients will be as follows: patients diagnosed with newly active pulmonary TB with a positive acid-fast bacilli sputum smear, aged >18 years, own a smartphone, and are able to use the LINE (Line Corporation) app. The exclusion criteria will be patients with a condition that requires the intervention of a specialist, rifampicin resistance according to a cartridge-based nucleic acid amplification test (GeneXpert MTB/RIF), unable to continue the treatment, and/or alcohol dependence. After the 2-month observation period, all sessions and follow-up clinical outcomes recorded will be retrieved. An intention-to-treat analysis will be performed to assess the compliance of both patients undergoing drug administration and their observers.

Results

The Human Research Ethics Committee, Faculty of Medicine, Prince of Songkla University approved the trial on February 19, 2021 (approval number 64-03618-9). The trial was funded in May 2021. The recruitment period will be from January 2022 to July 2022. The observation is scheduled to end by September 2022.

Conclusions

If the VOT shows superiority in observational compliance among patients and observers, the existing DOT policy will be replaced with VOT.

Trial Registration

Thai Clinical Trials Registry TCTR20210624002; https://www.thaiclinicaltrials.org/show/TCTR20210624002

International Registered Report Identifier (IRRID)

DERR1-10.2196/38796
Measurement of Adherence to mHealth Physical Activity Interventions and Exploration of the Factors That Affect the Adherence: Scoping Review and Proposed Framework (Preprint)
Authors: Yang Yang , Boulton Elisabeth , Todd Chris
Published: June 2022

BACKGROUND

Mobile health (mHealth) is widely used as an innovative approach to delivering physical activity (PA) programs. Users’ adherence to mHealth programs is important to ensure the effectiveness of mHealth-based programs.

OBJECTIVE

Our primary aim was to review the literature on the methods used to assess adherence, factors that could affect users’ adherence, and the investigation of the association between adherence and health outcomes. Our secondary aim was to develop a framework to understand the role of adherence in influencing the effectiveness of mHealth PA programs.

METHODS

MEDLINE, PsycINFO, EMBASE, and CINAHL databases were searched to identify studies that evaluated the use of mHealth to promote PA in adults aged ≥18 years. We used critical interpretive synthesis methods to summarize the data collected.

RESULTS

In total, 54 papers were included in this review. We identified 31 specific adherence measurement methods, which were summarized into 8 indicators; these indicators were mapped to 4 dimensions: length, breadth, depth, and interaction. Users’ characteristics (5 factors), technology-related factors (12 factors), and contextual factors (1 factor) were reported to have impacts on adherence. The included studies reveal that adherence is significantly associated with intervention outcomes, including health behaviors, psychological indicators, and clinical indicators. A framework was developed based on these review findings.

CONCLUSIONS

This study developed an adherence framework linking together the adherence predictors, comprehensive adherence assessment, and clinical effectiveness. This framework could provide evidence for measuring adherence comprehensively and guide further studies on adherence to mHealth-based PA interventions. Future research should validate the utility of this proposed framework.
mHealth Research for Weight Loss, Physical Activity, and Sedentary Behavior: Bibliometric Analysis (Preprint)
Authors: Wu Chieh-Chen , Huang Chih-Wei , Wang Yao-Chin , Islam Md.Mohaimenul , Kung Woon-Man , Weng Yung-Ching , Su Chun-Hsien
Published: June 2022

BACKGROUND

Research into mobile health (mHealth) technologies on weight loss, physical activity, and sedentary behavior has increased substantially over the last decade; however, no research has been published showing the research trend in this field.

OBJECTIVE

The purpose of this study was to provide a dynamic and longitudinal bibliometric analysis of recent trends of mHealth research for weight loss, physical activity, and sedentary behavior.

METHODS

A comprehensive search was conducted through Web of Science to retrieve all existing relevant documents published in English between January 1, 2010, and November 1, 2021. We developed appropriate research questions; based on the proven bibliometric approaches, a search strategy was formulated to screen the title for eligibility. Finally, we conducted bibliometric analyses to explore the growth rate of publications; publication patterns; and the most productive authors, institutions, and countries, and visualized the trends in the field using a keyword co-occurrence network.

RESULTS

The initial search identified 8739 articles, of which 1035 were included in the analyses. Our findings show an exponential growth trend in the number of annual publications of mHealth technology research in these fields. JMIR mHealth and uHealth (n=214, 20.67%), Journal of Medical Internet Research (n=71, 6.86%), and BMC Public Health (n=36, 3.47%) were the top 3 journals, publishing higher numbers of articles. The United States remained the leading contributor in these areas (n=405, 39.13%), followed by Australia (n=154, 14.87%) and England (n=125, 12.07%). Among the universities, the University of Sydney (n=36, 3.47%) contributed the most mHealth technology research in these areas; however, Deakin University (n=25, 2.41%) and the National University of Singapore (n=23, 2.22%) were in the second and third positions, respectively.

CONCLUSIONS

Although the number of papers published on mobile technologies for weight loss, physical activity, and sedentary behavior was initially low, there has been an overall increase in these areas in recent years. The findings of the study indicate that mobile apps and technologies have substantial potential to reduce weight, increase physical activity, and change sedentary behavior. Indeed, this study provides a useful overview of the publication trends and valuable guidance on future research directions and perspectives in this rapidly developing field.
The impact of question format on teenagers’ self-disclosure when answering health-related questions: a within-subject experimental design (Preprint)
Authors: Nassih Oumaima , Senecal Sylvain , Coursaris Constantinos , Léger Pierre-Majorique , Rochon Laurie-Jade
Published: June 2022

UNSTRUCTURED

Nowadays, adolescents have more access to electronic devices and the internet than ever before. The fast adoption of social networking for everyday life purposes has made it difficult for them to refrain from being in a perpetual state of connectivity. In parallel with that, a mental-health epidemic affecting this same generation has emerged, linking the excessive use of technology to the development of mood-related disorders like depression and anxiety. That being said, efforts are being made, by researchers and clinicians, in developing online tools, like chatbots, to provide a much-needed support to younger individuals in their mental health struggles. The purpose of this research is to help improve the efficacy of online mental-health interventions by exploring how variations of question formats lead to greater levels of self-disclosure, which, in turn, improve the efficacy of the mental health intervention.
This study explores how different question formats affect adolescents’ likelihood to self-disclose when answering health-related questions. For that, we evaluated the effect of variations in context, language and emojis on the likelihood to provide answers. In order to verify our hypotheses, we conducted a within-subject online survey with teenagers (N=125). Results showed that there is a significant correlation between the three independent variables (i) context, (ii) emojis and (iii) language, and adolescents’ self-disclosure for health-related questions. Several theoretical and managerial implications of this study are outlined in this paper.
m-Health Technologies for Managing Problematic Pornography Use: A Literature Review and Content Analysis of Current Apps (Preprint)
Authors: Henry Nathan , Donkin Liesje , Williams Matt , Pedersen Mangor
Published: June 2022

BACKGROUND

Several mobile apps are currently available that purportedly help with managing pornography addiction. However, the utility of these apps is unclear, given the lack of literature on the effectiveness of m-Health solutions for problematic pornography use (PPU).

OBJECTIVE

This study aimed to characterize the purpose and content of mobile apps that claim to manage pornography addiction.

METHODS

The phrase ‘pornography addiction’ was entered as a search term for the two major mobile phone platforms (Android and iOS). Apps were included in the analysis if they were described as reducing pornography use, and data were extracted from the store descriptions of the apps.

RESULTS

In total, 170 apps from both app stores met the inclusion criteria. The five most common and popular features, both in terms of number of apps with each feature (NAF) and minimum possible number of installations (MPNI) were the ability to track the time since last relapse (NAF=42%, 72/170; MPNI=6,388,000), tutorials and coaching (NAF=37%, 63/170; MPNI=9,286,505), access to accountability partners or communities (NAF=30%, 51/170; MPNI=5,544,500), content blocking or monitoring (NAF=27%, 46/170; MPNI=17,883,000), and badges (NAF=20%, 34/170; MPNI=4,425,300). Of these features, content blocking or monitoring had the highest MPNI. Content blocking was also the most detected feature combination in a combinations analysis (with 28 apps having only this feature), but also had the lowest mean consumer satisfaction rating (4.04) and second-lowest median rating (4.00) out of 5 stars.

CONCLUSIONS

There are several apps with the potential to provide low- or zero-cost, real-time interventions for people struggling to manage PPU, particularly those who are unable or unwilling to access a therapist. However, there is currently little evidence to support the effectiveness and safety of these apps. Further research is required to be able to provide recommendations about which apps (and app features) are safe for public consumption. This research strategy may enable the creation of combination therapies that employ a ‘Defence in Depth’ approach to manage PPU.

CLINICALTRIAL

pornography; pornography addiction; m-Health; problematic pornography use (PPU); mobile intervention; Just-In-Time Adaptive Intervention; smartphone-based therapy; addiction; psychology; Internet addiction
The agreement between virtual patients and unannounced standardized patients in evaluating primary healthcare quality: a multicentred, cross-sectional study in seven provinces of China (Preprint)
Authors: Zeng Minrui , Cai Yiyuan , Cao Jin , He Qianyu , Wang Xiaohui , Lu Yun , Liang Huijuan , Xu Dong Roman , Liao Jing
Published: June 2022

BACKGROUND

The unannounced standardized patient (USP) is the gold standard for primary healthcare (PHC) quality assessment but has many restrictions associated with high human and resource costs. Virtual patient (VP) is a valid, low-cost software for simulating clinical scenarios, and is widely used in medical education. Whether it can be used to assess the quality of PHC remains unknown.

OBJECTIVE

This study aimed to examine the agreement of VP and USP in the PHC quality assessment, and to identify factors influencing the VP-USP agreement.

METHODS

Eleven matched USP-VP cases were developed based on clinical guidelines and were implemented on a convenient sample of urban PHCs in the capital city of the seven-study provinces. 720 USP visits were conducted, whereby on-duty primary healthcare providers who met inclusion criteria were randomly selected by the USPs and further received a VP assessment of the same case condition at least a week later. The VP-USP agreement was measured by concordance correlation coefficient (CCC) for continuity scores and weighted kappa for diagnosis. Multiple linear regression was applied to identify factors influencing VP-USP agreement.

RESULTS

Only 146 VP scores were matched with original USP scores. The CCC of medical history was 0.37 (95%CI 0.24, 0.49), physical examination was 0.27 (95%CI 0.12, 0.42), laboratory and imaging test was -0.03 (95%CI -0.20, 0.14), and treatment was 0.22 (95%CI 0.07, 0.37). The weighted kappa of diagnosis was 0.32 (95%CI 0.13, 0.52). The multiple linear regression model indicated that VP tests were significantly influenced by the different case conditions and the cities studied.

CONCLUSIONS

The agreement was low between VP and USP in PHC quality assessment. It may reflect the know-do gap, while VP test results were also influenced by different case conditions, VP’s interactive design and usability. Further modifications for VP’s usability should be user-centred, paying attention to balance usability enhancement and hints avoidance.
"Examining concurrent validity and item selection of the Wants and Needs Outcome Measure (SWAN-OM) in a web-based therapy service" (Preprint)
Authors: De Ossorno Garcia Santiago , Edbrooke-Childs Julian , Salhi Louisa , Ruby Florence , Sefi Aaron , Jacob Jenna
Published: June 2022

BACKGROUND

Single-session mental health interventions are frequently attended by children and young people in both web-based and face-to-face therapy settings. The Session “Wants” and “Needs” Outcome Measure (SWAN-OM) is an instrument developed in a web-based therapy service to overcome challenges of collecting outcomes and experiences of single-session therapies. It provides pre-defined goals of the session, selected by the young person prior to the intervention, on which progress towards achievement is scored at the end of the session.

OBJECTIVE

To evaluate the instrument’s psychometric properties, including concurrent validity against other frequently used outcome and experience measures, at a web-based service.

METHODS

The SWAN-OM was administered for a period of six months to 1401 children and young people (aged 10 to 32; 79.3% White; 77.59% female) accessing single-session therapy in a web-based service. Item correlations with comparator measures and hierarchical logistic regressions to predict item selection were calculated for concurrent validity and psychometric exploration.

RESULTS

Most frequently selected items are “Feel better” (N= 431; 11.61%) and “Find ways I can help myself” (N= 411; 11.07%); unpopular items are “Feel safe in my relationships” (N= 53; 1.43%) and “Learn the steps to achieve something I want” (N= 58; 1.56%). The SWAN-OM is significantly correlated with the Experience of Service Questionnaire (ESQ), particularly the item: “Feel better”(rs(109) = .48, p < .001), the Youth Counselling Impact Scale (YCIS), particularly the item: “Learn the steps to achieve something I want” (rs(22) = .76, p < .001), and the Positive and Negative Affect Schedule (PANAS), particularly the items: item “Learn how to feel better” (rs(22) = .72, p < .001) and were “Explore how I feel” (rs(70) = -.44, p < .001).

CONCLUSIONS

The SWAN-OM demonstrates good concurrent validity with common measures of outcome and experience. Analysis suggests that lesser endorsed items may be removed in future iterations of the measure, to improve functionality. Future research is required to explore SWAN-OM’s potential to measure meaningful change, in a range of therapeutic settings.
COVID-19 and Mental Health; A Syndemic Perspective (Preprint)
Authors: Saqib Kiran , Qureshi Afaf Saqib , Butt Zahid Ahmad
Published: June 2022

BACKGROUND

The COVID-19 pandemic is an epidemiological and psychological crisis; what it does to the body is quite well known by now, and more research is underway, but the syndemic impact of COVID-19 and mental health on underlying chronic illnesses among the general population is not completely understood.

OBJECTIVE

This review was conducted to understand the impact of COVID-19 and mental health on underlying chronic illnesses and their interactions among the general population from a syndemic perspective.

METHODS

We carried out a literature review to identify the potential impact of COVID -19 and related mental health issues on underlying comorbidities that could affect the overall health of the population.

RESULTS

Many available studies have highlighted the impact of COVID-19 on mental health only, but how complex their interaction is in patients with comorbidities and COVID-19, the absolute risks and how they connect with the interrelated risks in the general population remain unknown. COVID-19 pandemic can be recognized as a syndemic due to; synergistic interactions among different diseases and other health conditions, increasing overall illness burden, emergence, spread and interactions between infectious zoonotic diseases leading to new infectious zoonotic diseases; and social and health interactions leading to increased risks in vulnerable populations and exacerbating clustering of multiple diseases.

CONCLUSIONS

There is a need to develop evidence to support appropriate and effective interventions for overall improvement of health and psychosocial wellbeing of at risk populations during this pandemic. The syndemic framework is an important framework that can be used to investigate and examine the potential benefits and impact of codesigning COVID-19/NCDs/Mental Health programming services which can tackle these epidemics concurrently.

CLINICALTRIAL

N/A
Prevalencia, tipos y factores etiológicos de apiñamiento mandibular tardío en pacientes de ortodoncia en Tabasco, México, 2015-2016
Authors: González Amaral Maury Gabriela , Rodríguez López Luz Verónica
Published: June 2022

El apiñamiento mandibular tardío es una maloclusión frecuente que se desarrolla entre los 15 y 20 años de edad, y que se ha asociado con diversos factores etiológicos, principalmente, a la erupción de los terceros molares inferiores, así como la discrepancia dentaria anterior, la longitud mandibular y el patrón de crecimiento de la misma. El objetivo de la presente investigación fue evaluar la prevalencia, tipos y factores etiológicos de apiñamiento mandibular tardío, en pacientes de ortodoncia, en Tabasco, México, 2015-2016. Fue un estudio observacional, analítico, de casos y controles. La muestra se conformó por 74 pacientes de nuevo ingreso de la Clínica de Posgrado de Ortodoncia de la Universidad Juárez Autónoma de Tabasco, entre agosto del 2015 y diciembre del 2016. Se revisaron expedientes clínicos, modelos y radiografías. Se obtuvo que la prevalencia de apiñamiento mandibular tardío fue de 83.7%, los tipos más comunes fueron el severo 26% y muy severo 27%. El 70% de los pacientes presentó mayor discrepancia dentaria anteroinferior. 26% de pacientes con apiñamiento mostraron longitud mandibular reducida. El patrón de crecimiento horizontal predominó en grupo de casos con 49% y en grupo control con 58%. La posición C de los terceros molares predominó tanto en ambos lados. Se concluye que ningún paciente con apiñamiento presentó un cuerpo mandibular disminuido ni patrón de crecimiento vertical. El apiñamiento puede presentarse independientemente de si están o no presentes los terceros molares inferiores
Sensibilidad y especificidad de un análisis radiográfico, tomográfico y de modelos digitales en la determinación de discrepancias transversales**
Authors: Guerra González Andrea , Fernández López Antonio , Tavira Fernández Silvia , Meléndez Ocampo, Arcelia , Escamilla Valencia Jair
Published: June 2022

Introducción: El diagnóstico en ortodoncia debe ser realizado en los tres planos del espacio para lograr una coordinación y armonía de arcadas al fi nal del tratamiento. Objetivo: Determinar la validez y sensibilidad del análisis radiográfi co de Ricketts, el análisis cefalométrico de Penn y el análisis de modelos de Hayes con el CAC utilizados para diagnosticar discrepancias transversales. Material y métodos: Se realizó un estudio descriptivo, transversal y comparativo en 100 tomografías Cone-Beam, 100 radiografías posteroanteriores y 100 modelos digitales pertenecientes a 50 pacientes con normoclusión y 50 pacientes con discrepancia transversal esquelé- tica; donde se hicieron el análisis tomográfi co de Penn, el análisis radiográfi co de la PA de Ricketts y el análisis de modelos de Hayes con el CAC. Resultados: En todas las comparaciones de los análisis transversales, la sensibilidad, la especifi cidad, el valor predictivo del test positivo y del test negativo, superaron el 85%. Conclusiones: El análisis de la PA de Ricketts posee más especifi cidad diagnóstica; mientras que, el análisis tomográfi co de Penn y el  análisis de modelos de CAC poseen más sensibilidad diagnóstica.
Tratamiento ortodóncico con sustitución funcional y estética de caninos con primeros premolares. Presentación de un caso
Authors: Bohórquez Jerez Yizzeth Nathalia , Vásquez Estrada Hugo Alberto
Published: June 2022

El diagnóstico y tratamiento de los órganos dentales ectópicos son necesarios con el fin de evitar complicaciones que comprometan la función, estabilidad y estética dental. El canino es el órgano dental que presenta mayor porcentaje de problemas de espacio en la arcada dental y es frecuente su erupción en una zona alta. Para tal fi n, se plantea un trabajo multidisciplinario, lo cual servirá para lograr los objetivos planteados que la ortodoncia por sí misma no podría conseguir de manera completa. Este artículo presenta a un paciente, clase I esquelética con el canino superior izquierdo ectópico, el cual presenta recesión gingival, canino inferior izquierdo retenido con raíz dilacerada, clase I molar bilateral, clase canina III derecha y clase canina izquierda no valorable, línea media desviada, dirección de crecimiento horizontal y birretroquelia. Se logró clase I molar bilateral, clase I canina derecha y clase I premolar izquierda, alineación y nivelación de arcos dentales, sobremordida horizontal y vertical adecuada, y línea media centrada.
ORTAOKUL MÜZİK KİTAPLARINDAKİ MAKAMSAL İÇERİKLİ ŞARKILARIN EŞLİKLENMESİNE YÖNELİK MÜZİK ÖĞRETMENİ GÖRÜŞLERİ
Authors: KOÇ Onur , GÜRPINAR Engin , EROY Ozan
Published: June 2022

Bu araştırmada, ortaokul müzik ders kitaplarındaki makamsal içerikli şarkıların eşliklenmesine yönelik müzik öğretmenlerinin görüşlerinin alınması ve değerlendirilmesi amaçlanmıştır. Ortaokul 5, 6, 7 ve 8. sınıflara ait müzik ders kitaplarındaki makamsal içerikli okul şarkıları; makam, karar sesleri ile usülleri bakımından incelenmiş ve sınıflara göre tasnif edilmiştir. Araştırmada mevcut durumların tespitine yönelik tarama ve müzik öğretmenlerinin mezuniyet türlerine göre öz-yeterlilikleriyle ilgili düşüncelerinin belirlenmesi amacıyla gerçekleştirilen bir nedensel karşılaştırma yöntemi kullanılmıştır. Araştırma kapsamında, müzik öğretmenlerine uygulanan anketin birinci bölümü; kişisel bilgilere yönelik sorular, ikinci bölümü ise makamsal içerikli şarkılara eşlik yapabilme durumlarını belirlemeye yönelik 34 anket sorusundan meydana gelmiştir. Ortaokullarda görev yapan müzik öğretmenlerine, makamsal içerikli şarkıların eşliklenmesine yönelik nicel veriler elde etmek için anket uygulanmıştır.

Araştırmanın örneklemini, maksimum çeşitlilik örnekleme yöntemine göre SEGE-2017 verileri dikkate alınarak oluşturulan 6 kademede yer alan 55 ilde görev yapan 300 müzik öğretmeni oluşturmuştur. Ortaokullarda görev yapan müzik öğretmenlerine, makamsal içerikli şarkıların eşliklenmesine yönelik nicel veriler elde etmek için anket uygulanmıştır.

Araştırmanın sonuçlarına göre; müzik öğretmenlerinin çoğunluğunun derslerinde eşlik yaptıkları, makamsal içerikli şarkıların eşliklenmesinde makamların genel olarak tanındığı ve bu eserlere eşlik yapabildikleri tespit edilmiştir.