bluuebunny/crossref_metadata_2025 huggingface dataset:
REPRESENTASI DESA DALAM FILM-TARI â€œDONGENG DARI DIRAHâ€ Analisis Semiotika Barthesian
Authors: Hudoyo Sapto
Published: June 2022

Film is a collaborative work that combines multiple art forms. Every form of art donatesrespective roles and supports each other. Film is created as a means of communicationvia meaningful visual language and affirmed-narrative. A film raises aesthetic values andmeaning by offering interpretation from its audience. The story telling throughchoreography on the step of post-production (editing) will bring new meaning, it makesa dance film more superior than the performances of casual dance. Dance has becomea means of creating a depth of meaning on purpose to be conveyed. By using a semiotictheory, a â€œSocerres From Dirahâ€ dance film which has rural setting can be perceivedthrough culture and religion of rural communities. Of the signs systems (signifier/expression and signified/contents), it has obtained connotative meaning of the effort,praying and expression of excitement for all the work done by rural communities inmaking a living for his family.
Penciptaan Video Dokumenter â€œDinding-Dinding Cagar Budaya Kota Yogyakartaâ€
Authors: Nugroho Widhi
Published: June 2022

Old building representing the indies colony was abandoned in several heritage districtsin Yogyakarta. The Government did not conduct a serious plan and act to conservethe heritage buildings based on the rules of heritage law. The old buildings in Yogyakartahas been mostly over 50th years old, and they have been considered as the heritagebuildings based on the Yogyakartaâ€™s history and the unique architecture. The Governmentand society should be concerned to conserve the heritage buildings in the self ways orcollaborate. This documentary video is one of the efforts of conserving the heritagebuilding in Yogyakarta.
Representasi Kesenian Tradisi Lenong Betawi Pada Tayangan Drama Komedi Nglenong Nyok Di Trans TV
Authors: Sugihartono Ranang Agung , Falasifah Anna
Published: June 2022

This discussion is intended to know the form of display of comedy drama ofÂ Nglenong Nyok, and how this comedy drama representsÂ lenong BetawiÂ traditional art in its display. This study was a descriptive qualitative study using an embedded single strategy. Source of data obtained from informants, documents, books, audio-visual displays, and internet. The sampling technique used was purposive sampling. Data were analyzed using an interactive model. The results showed thatÂ Nglenong NyokÂ is an event with a sitcom format, which looks at the troubleshooting at the end of each episode within 30 minutes and the fourth element which is characteristic of a sitcom that is the fact that the story is presented, the language used, characters, and place. Overall, the comedy drama of Nglenong Nyok as an adaptation display can represent a lenong show into the display, although the production process has undergone development in some elements. Still keepholding on guidelines (grip, Java) of the showlenong BetawiÂ is evidence that the comedy drama ofÂ Nglenong NyokÂ is able to represent the lenong show in the middle of the television business that requires the program makers to be more concerned with profit than the quality. Keywords:Â representation, Lenong, Betawi, Nglenong Nyok, and Trans-TV
Eksplorasi Fenomena Waktu Sebagai Objek Penciptaan Seni Video
Authors: Triadiputra Stephanus Andre
Published: June 2022

The debate on the speed of time (travel time, the length of the process, working time) has been going on since time immemorial and continues to this day. At this time the meaning of the word quickly in human life not only be the size of an improvement, but it is also considered to be a measure for better circumstances. Around us, the conditions under which it can be said that the central human race by speed. Most of the time of the human life cycle of time spent on a job that runs in a high-tempo pace. Things like that make a man trapped inside a rhythm acceleration. Slow follow the changes are considered outdated. Not fast also believed would make the economic benefits will be slightly reduced. Instead, speed is believed to be able to make financial gains accrue and be used as an indicator of the progress of human life. That is, human life would be considered better if he is able to more quickly than any other human. Through research and phenomenological theory approach the author tries to trace the phenomenon of time. The rhythm of life of modern man feels faster tempo is the main focus. Anxiety that the authors feel the phenomenon push to make it into a work of video art. This video art is a medium of expression that is at once the author tries to explore the phenomenon of modern human life time which more quickly than before. Hopefully, this work could be stand as a contemplation media of the meaning of time for the audience. Keywords: time, fast, phenomenon, phenomenology, and expression
Komikalisasi Politik Pada Program Televisi Kabar Bang One: Episode Dipercaya (Analisis Visual Semiotika Roland Barthes )
Authors: Sjafiâ€™i Ahmad , Mujiyono Mujiyono
Published: June 2022

The focus of this study is the problem of how to structure political content displayedcomically in visual of the characters of the news program Bang One: Episode Dipercayain TV One, by Roland Barthes semiotic viewpoint. This study used a qualitative descriptivemethod. This research analyzes the characters and visual elements on the news BangOne: Episode Dipercaya. In order to assess the political concepts contained in newsprograms Bang One: Episode Dipercaya, used descriptive structure approach. The maindata sources in this study is a video news show Bang One: Episode Dipercaya equippedwith supporting data in the form of written sources and pictures. The results showedthat the visual concept characterizations of the characters in news programs Bang One:Episode Dipercaya based on conflict is relied on the work on the arrest of the criminalswho cause a crisis of confidence personal to the communal. This concept is shownthrough the medium of animation that describes the role of the characters and theirinteraction with the visual setting concept of location; supporting visual elements suchas text, bumper opening, and said balloon; and scenes each scene in news programs BangOne: Episode Dipercaya.Keywords: Bang One News, comicalization, visual, dan semiotics.
Kostum Dalam Membangun Karakter Tokoh Pada Film Soekarno
Authors: Sugihartono Ranang Agung , Sintowoko Dyah Ayu Wiwid
Published: June 2022

This study discusses the procedures of costumes and characters in the Sukarnofilm. This qualitative descriptive research apply the Sukarno film as source of data. Thecollection of data by purposive sampling, with the method of observation, interviews,and literature. Data were analyzed through data reduction, data display, drawingconclusions and verification process. The results showed that the costumes portraythe characterization of the characters. Costume adjusted with basic clothing, headclothing, body clothing, legs underwear, and accessories are known for costume parts.Each character has a unique costume and a differentiator from other figures. Costumealso build characterization of actors according to the physiological dimension (neatness,cleanliness, beauty, beauty, valor, charm, charisma, and authority). Sociological dimensionsindicate socioeconomic class, role in the family / community, ideology, ancestry, levelof education, religion, ethnicity / race, and interaction between the actors. While thepsychological dimensions adapted to the atmosphere and scene. Color and layoutcostume describing feelings, honesty, sincerity, emotion, desire, desire, passion, inneraction, as well as the vision of each character in the film.Keywords: costume, characterization, actor, film, and Soekarno
¿Qué se investiga sobre la tecnociencia en Iberoamérica?
Authors: Osorio García Maribel
Published: June 2022

El presente texto consiste en una aproximación al estado de conocimiento de la tecnociencia en la región de Iberoamérica y España, con el propósito de reconocer sus principales líneas de estudio. Se incluyen trabajos de acceso libre, de habla hispana y publicados en los últimos 10 años, privilegiando los artículos científicos de revistas arbitradas o indizadas, los cuales constituyen la mayoría de los documentos consultados. Se reconoce que la tecnociencia es un concepto de naturaleza multidisciplinaria, pero con mayor atención por parte de las ciencias sociales y humanidades; concentrando la mayor producción España, Colombia y México. Las líneas de estudio fueron: las posiciones ontológicas y teórico-epistemológicas, la deshumanización y ética, la construcción social, la democracia y el poder, y la educación.
The Ideal Concept of the Position Judges as State Officials in the Ius Constituendum in Indonesia
Authors: H. Adies Kadir
Published: June 2022

Problems regarding the position of judges that continue to continue will affect their duties in upholding law and justice. Provisions regarding the position of judges in several statutory provisions are also considered to have multiple interpretations and are inconsistent. To find out more fully, this paper will first analyze and criticize the concept of judges in the Draft Law on the Office of Judges, then provide the ideal concept of the position of judges as state officials in the ius constituendum in Indonesia. This study uses normative legal research with a statutory and conceptual approach. The results of the study are tThere are several crucial issues in the Draft Law on the Position of Judges, which among others are related to 1) The Government's Rejection of the Status of all Judges as State Officials; 2) Periodization of the position of Supreme Court Justices; 3) Sharing of Judges Recruitment Authority with the Judicial Commission; and 4) Reduction of Judge's Retirement Age. Then to realize the ideal position of judges in the future in the ius constituendum, changes need to be made through changes in concepts ranging from; 1) the concept of judges as State Officials; 2) Supreme Court Institutional Structure; 3) Mechanism of Promotion, Demotion, Mutation, Reword and Punishment of Judges; 4) Strengthening the Retirement Age of Judges in Indonesia; 5) Court of Appeals and Classification of Cases Entering the Supreme Court; 6) The concept of the Judicial Commission in Maintaining Judges' Dignity; 7) Regulation of Ad Hoc Judges and Special Courts in Indonesia; and 8) Recruitmentand Education of Candidates for Judges.
Impact and Strategy of PT. Dirgantara Indonesia (DI) to Get Out of the Crisis During the Covid 19 Pandemic
Authors: Tommy Rahadian Setiaji  , Muhammad Syaroni Rofii  , Achmad Sanusi
Published: June 2022

During the Covid-19 pandemic, it strikes all over the world. One of them is in the field of aviation, especially flights in Indonesia. The innovation process for public transportation companies that produce transportation services to the public who use transportation services (users), then in principle there are four functions of transportation service products, namely safe, orderly and regular, comfortable, and economical. The research methodology used is qualitative. The existence of the strategic defense industry of PT. Dirgantara Indonesia (DI) is a manifestation of the desire of the Indonesian people to use domestically produced defense equipment aimed at supporting the defense system.
FASILITASI KEBUTUHAN ATAS PENGHARGAAN DIRI UNTUK MENDUKUNG PEMBELAJARAN KIMIA DI ERA SOCIETY 5.0
Authors: Hanna S. R. P , Dera S. , Sali A.
Published: June 2022

Indonesia has entered Revolution 4.0 where technology has become the basis of human life. Slowly but sure, Indonesia is entering the Society 5.0 Era characterized by (1) freedom; (2) customization; (3) scrutiny; (4) integrity; (5) entertainment; (6) speed; and (7) innovation. Society 5.0 offers a human-centered society that makes a balance between economic progress and solving social problems through a highly connected system between the virtual and real world. According to the Japanese prime minister, Shinzo Abe, explained in the World Economic Forum (WEF) that the Society 5.0 is no longer about capital, but data that connects and mobilizes all fields such as education and health that must fill the gap in society. At this time, we will propose the role of education in the Era of Society 5.0, especially related to chemistry learning that facilitates the need for self-esteem. Human needs are the same, such as basic needs, described as the hierarchy of needs by Maslow's Theory. The need for self-esteem is one of the needs of human psychology that must be fulfilled, especially for students to face the challenges of the Era of Society 5.0 to enrich chemistry learning as a need for a more meaningful life. The participants are 34 Grade X students from Natural Science Class 2 of Public High School (SMA NEGERI) 18 Jakarta. The data are pretest by Likert Scale Questionnaire, and posttest by a simple chemistry learning module with topic acid-base equilibrium.

 

Keywords: Society 5.0; need for self-esteem; chemistry.
PEMBELAJARAN MATEMATIKA REALISTIK BERBASIS KONTEKSTUAL UNTUK MATERI GEOMETRI PADA SISWA KELAS VII SMPN 2 ENDE SELATAN
Authors: Mei A. , Naja F.Y. , Sa’o S.
Published: June 2022

The Role of mathematics in the development of science and technology in everyday life is increasingly important. Therefore it is necessary to find various strategies to improve students' ability to understand mathematics so that they are able to face the problems faced. In order for mathematics learning to be meaningful then classroom learning must associate mathematical concepts with everyday student experiences. The purpose of this study is to produce learning tools and find out student learning outcomes, the type of experimental research that begins with the development of devices, in this study used descriptive analysis to determine the effectiveness of learning tools and inferential statistical analysis to find out whether student learning outcomes following realistic contextual mathematics learning better than the learning outcomes of students who take conventional learning. The results of descriptive analysis obtained realistic mathematics learning based on effective context. And the results of inferential analysis obtained learning outcomes of students who take realistic mathematics learning is better than the learning outcomes of students who take conventional learning, this can be seen by using a significant level  = 5% obtained F (0.95; 2; 67) = 3.13 , means F *> F (0.95; 2; 67), then H0 is rejected. This means that the linear regression model of the experimental class and the control class are different. This shows that contextual based realistic mathematics learning can improve student learning outcomes in class VII of SMP Negeri 2 Ende Selatan
PEMBELAJARAN QUANTUM TEACHING TERHADAP HASIL BELAJAR SISWA KELAS VII SMP KATOLIK SINT ALOYSIUS NIKI-NIKI KABUPATEN TIMOR TENGAH SELATAN
Authors: Missa Hildegardis , Boy Baunsele Anselmus
Published: June 2022

This study aims to determine the effect of the Quantum Teaching model on the learning outcomes of seventh grade students of Sint Aloysius Niki-Niki Catholic Middle School. This type of research is quantitative research with a quasi-experimental method and the research design used is the Nonrandomized Control group Pretest-Posttest Design. The population in this study were all seventh grade students of Sint Aloysius Niki-Niki Catholic Middle School. The data analysis technique used descriptive analysis and inferential analysis. The results showed that the post test score in the experimental class that applied the Quantum Teaching model was higher, namely 86.37 compared to the control class who applied the conventional learning model, namely 69.13. Anacova test results show the calculated F value is 0,000 or less than 0.05. This shows that H0 which states that there is no effect of the Quantum Teaching model on the learning outcomes of seventh grade students of Sint Aloysius Niki-Niki Catholic Middle School is rejected and the consequence is that Ha states that there is an effect of the Quantum Teaching model on the learning outcomes of seventh grade students of SMP Catholic Sint Aloysius Niki Niki accepted. The results of the activities of students who took part in the experimental class were also higher at 90%. compared to the control class, namely 86.65%. And the teacher's ability to manage learning in the experimental class is included in the good category, namely 98.91%.
PENGARUH MODEL PEMBELAJARAN PROBLEM BASED LEARNING TERHADAP KEMAMPUAN PEMECAHAN MASALAH MATEMATIS
Authors: Muhammad Rizky Mazaly  , Doni Irawan Saragih  , Lavenia Ulandari
Published: June 2022

The objectives of this study were as follows firstly, to identify whether there was an improvement of students' mathematical problem solving ability treated with problem -  based learning, rather than those who obtained ordinary learning; and secondly, to recognize the process of students' answers in each learning.  This research was a quasi-experimental research.  The population in this study consisted of all students in class VIII at SMP Budi Agung Medan totaling 345 students, by a sample of two classes totaling 60 students.  Data analysis was performed with the Manova Statistical Test.  The results of this study showed that the improvement of students' mathematical problem solving abilities treated with problem basedearning was better than that of those obtaining regular learning, and the process of students' answer treated with problem based earning was more complete than that of the students' with ordinary learning.
SKRINING FITOKIMIA DARI SENYAWA METABOLIT SEKUNDER BUAH JAMBU BIJI MERAH (Psidium guajava L.)
Authors: Harahap Siti Nurlani , Nurbaity Situmorang
Published: June 2022

Guava (Psidium guajava L.) is a tropical plant come from southern Mexico and Central America. Red guava fruit has many benefits, one of them is to control fruit fly pests on plants. In red guava fruit is presumed to contain secondary metabolite compounds can be used as natural attractants for fruit fly pests. This study aims to determine the content of secondary metabolite compounds found in red guava (Psidium guajava L.). This research used the qualitative experimental methods. The research started with processing red guava fruit samples into the powder of simpilisa. The powder of simplicia was then macerated with methanol as a solvent at a ratio of 1: 3 for + 5 days. The maceration result was extracted again by rotary evaporator to obtain the concentrated extract. The concentrated extract was screened for phytochemicals to determine the metabolite compounds contained in the sample. The results showed that the secondary metabolites in red guava fruit (Psidium guajava L.) were positive for flavonoids, alkaloids, tannins / phenolics, terpenoids / steroids. whereas the saponin test showed negative results. We can concluded that guava fruit extract (Psidium guajava L.) contains flavanoids, alkaloids, terpenoids / steroids and tannins / phenolic.
PISANG BATU Musa Balbisana COLLA : KAJIAN BOTANI DAN PEMANFAATANNYA
Authors: Hastuti Hastuti
Published: June 2022

Indonesia is the center of the world's banana biodiversity, which is estimated to have 325 cultivated banana varieties and 12 wild banana species. One of the wild bananas that is still easy to find but has not been optimally utilized is the type of stones banana (Musa balbisiana). Apart from its leaves which are widely used as a wrapper for various kinds of traditional food, the heart of stone bananas is also widely used as a mixture of several types of traditional foods such as lawar. Stone bananas are also known to be used as traditional medicine in several areas. In addition, several research results reveal several pharmacological potentials of stone bananas such as anti-microbial, anti-malarial and antioxidant properties. The data used in this article were obtained through online and offline literature studies. The data obtained were then analyzed, synthesized then compiled and summarized to obtain information about the content and utilization of stone bananas. The purpose of this article is to gather information on the use of stone bananas in traditional medicine and some research that reveals its potential. This article is expected to provide information for the development of the potency of stone bananas both in traditional medicine and in modern medicine.
BILANGAN DOMINASI LOKASI PADA LINE PAN GRAPH DAN MIDDLE PAN GRAPH
Authors: Fran Fransiskus , Yohana Elishabet , Yundari Yundari
Published: June 2022

Let G is a simple, connected, and undirected graph. A set D is a subset of V. If every node of  V adjacent to at least one node D, then D is a dominating set of the graph G . One of the topics from dominating set is locating dominating set. Locating dominating set is dominating set on condition if every two vertices u,v elements of V-D satisfy the intersection of N(v) and D not equal to the intersection of N(u) and D  with u not equal to v. The locating domination number of a graph G  is the minimum cardinality of a locating dominating set in a graph G . In this study discussed the locating domination number on line pan graph (L(Tn,1)) and middle pan graph (M(Tn,1)). Locating domination number was obtained by finding dominating set from some graph. Then, does the dominating set meet the condition of locating dominating set? If it meets locating dominating set condition, then we can find the locating domination number of the graphs. In the last procedure, we get pattern location domination number of line pan graph and middle pan graph. The results of the study obtained the locating domination number of (L(Tn,1)) and  (M(Tn,1)) consecutive are floor function of (2n/5)+1  and floor function of ((2n+1)/3)+1.
Procesné a organizačné súvislosti zmeny názvu obce a jej časti
Authors: Tomáš Lukáš
Published: June 2022

In the presented article, the author analyzes the procedural and organizational aspects of changing the name of the municipality and its part. It formulates reflections on whether the beginning of the process of changing the name of the municipality is conditioned by procedural activity on the part of the municipality, or whether it is possible only at the initiative of the Government of the Slovak Republic. There have been different legal views on this issue in the application practice of the Government of the Slovak Republic, the Central State Administration and the administrative courts. The author also brings a comparative view of the modification of the name of the village and part of the village. He examines these aspects from the point of view of legal theory and applied practice. In the indicated contexts, the comparison of the Slovak legal regulation with the relevant diction of foreign municipal establishments does not omit either. It also presents its own proposals for a possible change in legislation in the future (de lege ferenda).
Action of granulopoiesis-stimulating cytokines rhG-CSF, rhGM-CSF, and rmGM-CSF on murine hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC).
Authors: Hofer M , Vacek A , Weiterová L
Published: June 2022

The aim of this study was to provide new data to the knowledge of mechanisms by which recombinant human granulocyte colony-stimulating factor (rhG-CSF), recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) and recombinant murine granulocyte-macrophage colony-stimulating factor (rmGM-CSF) enhance the numbers of colonies growing from hematopoietic progenitor cells for granulocytes and macrophages (GM-CFC) in the murine bone marrow. The in vitro technique for cultivating GM-CFC from normal bone marrow cells was used. For evaluation of stimulatory actions of the drugs studied, the factors themselves or sera of mice given these factors were added to the cultures. The factors or the sera were present in the cultures either as the only potentially stimulatory agents or acted jointly with a suboptimum concentration of recombinant murine interleukin-3 (rmIL-3). It was found that both rhG-CSF and rmGM-CSF stimulate the proliferation of GM-CFC by a combination of direct mechanisms (direct actions on the target cells) and indirect effects (effects mediated through the induction of other cytokines and/or growth factors in the murine organism). The rhGM-CSF exhibited somewhat weaker in vitro effects in comparison with the other two factors and only indirect effects were noted. Additional in vivo experiments documented that, in spite of differences in mechanisms of action of the individual drugs studied on murine bone marrow cells in vitro, equal in vivo doses of the factors induce quantitatively similar effects on the production of GM-CFC in vivo.
Spontaneous quantal and non-quantal release of acetylcholine at mouse endplate during onset of hypoxia.
Authors: Bukharaeva EA , Salakhutdinov RI , Vyskočil F , Nikolsky EE
Published: June 2022

At 20 (0)C, both quantal and non-quantal spontaneous acetylcholine release (expressed as miniature endplate potential frequency [f-MEPPs] and the H-effect, respectively) increased during the first 30 min of hypoxia in solution with normal extracellular calcium ([Ca(2+)](o) = 2.0 mM). The hypoxia-induced tenfold increase of the f-MEPPs was virtually absent in low calcium solution([Ca(2+)](o) = 0.4 mM) whereas there was still a significant increment of non-quantal release. This indicates that each of these two processes of acetylcholine release is influenced by mechanisms with different oxygen sensitivity. The rise of f-MEPPs during the onset of hypoxia apparently requires Ca(2+) entry into the nerve terminal, whereas the non-quantal release can be increased by another factors such as a lower level of ATP.
Pemanfaatan Teknologi Pembelajaran Di Masa Pandemi Covid-19
Authors: Nahariah Nahariah
Published: June 2022

Penelitian ini bertujuan untuk membahas tentang pentingnya Teknologi Informasi dalam mengatasi wabah virus covid-19. Berdasarkan laporan terbaru. Berdasarkan data yang diperoleh, menyatakan bahwa ada 175,4 juta pengguna internet di Indonesia telah menggunakan internet. Berdasarkan hasil analisa kualitatif, pengamatan langsung, dapat disimpulkan bahwa internet telah menjadi media yang memberikan informasi ke masyarakat tentang bahaya dan upaya pencegahan Covid 19. Namun, kelemahan dari teknologi informasi diantaranya sulitnya menyaring informasi yang benar atau salah sehingga pengguna harus memilah dan menyikapi setiap informasi yang dibaca dari teknologi internet. Masyarakat perlu mewaspadai wabah virus covid-19 yang telah menyebar ke ratusan negara di dunia, termasuk negara Indonesia. Oleh karena itu, teknologi informasi seharusnya menjangkau ke pelosok desa. Berkaitan dengan aspek kesehatan, teknologi informasi sepatutnya menjangka hingga satuan puskesmas dan terintegrasi dengan rumah sakit perkotaan.
Learning Motivation in Educational Psychology: A Comparative Study between General Educational Psychology and Islamic Educational Psychology
Authors: Badridduja Faiz , Lessy Zulkipli , Latipah Eva , Subaidi Subaidi
Published: June 2022

This article tries to uncover and unravel the essence of learning motivation from two different perspectives or starting points, namely General Educational Psychology and Islamic Educational Psychology. The purpose of writing this article is to describe the similarities and differences between these two educational psychology ideas when explaining one of the core discussions in them, that is learning motivation by comparing the both (comparison). The research method used is library research, have as a source from books and scientific journals that have a relation in this research, while the type or substancial of writing this article is descriptive comparative. The results of the main findings are that there are differences between general educational psychology and Islamic educational psychology, where western theories are only worldly and short-term, while in Islamic thoughts they are more ukhrawi or to life after death. Although both of them think that motivation has a very important role in the world of education.

Keywords: Learning Motivation, Educational Psychology, Islamic Educational Psychology
Relationships Weight Loss Mother With Hormonal Birth Control Usage
Authors: Herawati Rika
Published: June 2022

Family planning, according to WHO (world health organization) expert commite 1970 is action that helps couples to avoid unwanted pregnancies, getting birth highly desired, set the interval between pregnancies and determine the number of children in the family (Sulistyawati, 2018). Objective To determine the relationship research Mom Weight Loss with use of hormonal birth control in the village Pekan Tebih Puskesmas Rokan Hulu. The research method used is Analytical Survey and the type of cross-sectional study. The population in the study were all women taking hormonal birth control as many as 129 people and the sample is saturated sample as many as 129 people. Results of research on the relationship of maternal weight with the use of hormonal birth control only get 69 respondents who are willing to be investigated, while the rest are not willing to study for a variety of reasons given by the respondents. Based on the data obtained is processed using computerized women taking birth control pills that there were 18 respondents (23.1%) and taking injections were 51 people (73.9%). Conclusion There is a relationship Weight Mom With Hormonal birth Pemakian Pekan Tebih Village Puskesmas Kepenuhan Hulu. Expected advice for other researchers can continue research on the use of mother Weight Loss Hormonal birth control and be used as a reference / reading especially things related about hormonal birth control.

Keywords: Hormonal Birth Control, Birth Control, Weight Loss
Thermal Conditioning Can Improve Thermoregulation of Young Chicks During Exposure to Low Temperatures
Authors: Ouchi Yoshimitsu , Chowdhury Vishwajit S. , Cockrem John F. , Bungo Takashi
Published: June 2022

The risk of climate change is increasing year by year and changing environmental temperatures will increasingly have effects on productivity in the poultry industry. Thermal conditioning is a method of improving thermotolerance and productivity in chickens (Gallus gallus domesticus) that experience high ambient temperatures. Thermal conditioning involves exposure of chickens to high temperatures at an early age. This conditioning treatment can affect tolerance to other type of stress. However, the effect of thermal conditioning on tolerance of low temperatures has not been investigated. Therefore, in this study we investigated the effect of thermal conditioning in chickens on thermoregulation during exposure to low temperatures. Three day-old female broiler chicks were exposed to high ambient temperatures (40°C for 12 h) as a thermal conditioning treatment. A control group of chicks was kept at 30°C. At 7 days-old, both groups of chicks were exposed to low temperatures (16 ± 0.5°C) for 3 h. Thermal conditioning treatment reduced the decrease in rectal temperature during cold exposure that occurred in control chicks. In addition, hypothalamic mRNA expression of brain derived neurotrophic factor, thyrotropin-releasing hormone and arginine vasotocin genes was higher in thermal conditioning treated chicks than control chicks. The mRNA expression of avian uncoupling protein in the liver was also higher in thermal conditioning chicks. These results suggest that thermal conditioning treatment can improve thermoregulatory mechanisms of chicks under low temperature environments.
Determination of Pleiotropic Effect of Warfarin in VKORC1 and CYP2C9 Genotypes in Patients With Heart Valve Replacement
Authors: Shafique Huma , Ashraf Naeem Mahmood , Rashid Amir , Majeed Asifa , Afsar Tayyaba , Daly Ann K. , Almajwal Ali , Alruwaili Nawaf W. , Khan Azmat Ullah , Razak Suhail
Published: June 2022

Warfarin has been widely used as an oral anticoagulant agent. In past, efforts have been done to study the contribution of genetic variation on warfarin dose requirements. The possible therapeutic dose determination of warfarin is very challenging, i.e., extremely low dose leading to unusable antithrombotic therapy or high dose causes particularly bleeding complications. Our study aimed to investigate these observations in more detail, we determined the correlation of interleukin-6 (IL-6), cyclooxygenase-2 (COX-2), and tumor necrosis factor-α (TNF-α) among VKORC1 and CYP2C9 genetic variants in patients with heart valve replacement who were treated with a range of warfarin doses and compared with levels in healthy controls. A total of 107 human subjects were recruited with low < 5 mg, medium 5–10 mg/day, and high > 10 mg/day warfarin doses. The genetic study of VKORC1–1639G/A, C1173T, 3730G > A, CYP2C9*2, and CYP2C9*3 was performed using TaqMan genotyping and DNA sequencing. The gene expression of IL-6, TNF-α, and COX-2 mRNA was analyzed. IL-6, TNF-α, and COX-2 protein expressions were determined by ELISA and Western blot analysis to evaluate the pro- and anti-inflammatory effects of warfarin. A statistically significant difference was found among the haplotypes of VKORC1 rs9934438 (C1173T), rs9923231 (−1639G > A), rs7294 (3730G > A) and CYP2C9 *2 p. Arg144 Cys (rs28371674), CYP2C9 *3 p. Ile359Leu (rs1057910) genotypes with warfarin dose requirements (p = 0.001). The increased levels of COX-2, IL-6, and TNF-α proteins were observed when a high dose of warfarin (>10 mg/ml) was administered. However, a lower concentration (1.0 mg/ml) was observed with decreased warfarin dose (<5 mg/day). The present study reported that in addition to its anticoagulant action, the genetic variants of warfarin may have a pleiotropic effect by influencing IL-6 depending on the dosing regimen and inducing the expression of COX-2.
Comparison of the Effect of Two Hybrid Models of Problem-Based Learning Implementation on the Development of Transversal and Research Skills and the Learning Experience
Authors: Carrió Mar , Baños Josep-E , Rodríguez Gemma
Published: June 2022

Problem-based learning (PBL) provides an encouraging learning environment to develop transversal and research thinking skills. However, how PBL is implemented into a curriculum can be critical for achieving these outcomes. This study compares two hybrid PBL implementation models applied in a health sciences school: a PBL-module integrated into the subjects of a traditional curriculum and full interdisciplinary PBL-courses. 651 students were involved, with 330 taking the PBL-module and 277 taking the PBL-courses. Students’ and tutors’ perceptions about the acquisition of the skills as well as their satisfaction with the learning experience were compared. The results showed that in the interdisciplinary PBL-courses, both students and tutors perceived a significantly higher acquisition of these skills. In addition, they also find the methodology more useful and are more satisfied with the learning experience than in the PBL-modules. A strong correlation was also observed between the acquisition of transversal and research skills and the perceived usefulness of PBL and overall satisfaction with the experience. This study provides new evidence on the characteristics of PBL that favor the development of these skills.
Toxoplasma gondii CDPK3 Controls the Intracellular Proliferation of Parasites in Macrophages
Authors: Wu Minmin , An Ran , Zhou Nan , Chen Ying , Cai Haijian , Yan Qi , Wang Ru , Luo Qingli , Yu Li , Chen Lijian , Du Jian
Published: June 2022

Interferon-γ (IFN-γ)-activated macrophages restrain the replication of intracellular parasites and disrupt the integrity of vacuolar pathogens. The growth of the less virulent type II strain of Toxoplasma gondii (such as ME49) was strongly inhibited by IFN-γ-activated murine macrophages. However, the mechanism of resistance is poorly understood. Immunity-related GTPases (IRGs) as well as guanylate-binding proteins (GBPs) contributed to this antiparasitic effect. Previous studies showed the cassette of autophagy-related proteins including Atg7, Atg3, and Atg12-Atg5-Atg16L1 complex, plays crucial roles in the proper targeting of IFN-γ effectors onto the parasitophorous vacuole (PV) membrane of Toxoplasma gondii and subsequent control of parasites. TgCDPK3 is a calcium dependent protein kinase, located on the parasite periphery, plays a crucial role in parasite egress. Herein, we show that the less virulent strain CDPK3 (ME49, type II) can enhance autophagy activation and interacts with host autophagy proteins Atg3 and Atg5. Infection with CDPK3-deficient ME49 strain resulted in decreased localization of IRGs and GBPs around PV membrane. In vitro proliferation and plaque assays showed that CDPK3-deficient ME49 strain replicated significantly more quickly than wild-type parasites. These data suggested that TgCDPK3 interacts with the host Atg3 and Atg5 to promote the localization of IRGs and GBPs around PV membrane and inhibits the intracellular proliferation of parasites, which is beneficial to the less virulent strain of Toxoplasma gondii long-term latency in host cells.
Benchmarking and Automating the Image Recognition Capability of an In Situ Plankton Imaging System
Authors: Le Kevin T. , Yuan Zhouyuan , Syed Areeb , Ratelle Devin , Orenstein Eric C. , Carter Melissa L. , Strang Sarah , Kenitz Kasia M. , Morgado Pedro , Franks Peter J. S. , Vasconcelos Nuno , Jaffe Jules S.
Published: June 2022

To understand ocean health, it is crucial to monitor photosynthetic marine plankton – the microorganisms that form the base of the marine food web and are responsible for the uptake of atmospheric carbon. With the recent development of in situ microscopes that can acquire vast numbers of images of these organisms, the use of deep learning methods to taxonomically identify them has come to the forefront. Given this, two questions arise: 1) How well do deep learning methods such as Convolutional Neural Networks (CNNs) identify these marine organisms using data from in situ microscopes? 2) How well do CNN-derived estimates of abundance agree with established net and bottle-based sampling? Here, using images collected by the in situ Scripps Plankton Camera (SPC) system, we trained a CNN to recognize 9 species of phytoplankton, some of which are associated with Harmful Algal Blooms (HABs). The CNNs evaluated on 26 independent natural samples collected at Scripps Pier achieved an averaged accuracy of 92%, with 7 of 10 target categories above 85%. To compare abundance estimates, we fit a linear model between the number of organisms of each species counted in a known volume in the lab, with the number of organisms collected by the in situ microscope sampling at the same time. The linear fit between lab and in situ counts of several of the most abundant key HAB species suggests that, in the case of dinoflagellates, there is good correspondence between the two methods. As one advantage of our method, given the excellent correlation between lab counts and in situ microscope counts for key species, the methodology proposed here provides a way to estimate an equivalent volume in which the employed microscope can identify in-focus organisms and obtain statistically robust estimates of abundance.
False-Positive Results of SARS-CoV-2 RT-PCR in Oropharyngeal Swabs From Vaccinators
Authors: Kong Xiang-Qi , Wang Yong-Jing , Fang Zan-Xi , Yang Tian-Ci , Tong Man-Li
Published: June 2022

Real-time reverse transcription-polymerase chain reaction (RT-PCR) is the gold standard for diagnosing coronavirus disease 2019 (COVID-19). However, RT-PCR may yield false-positive results, leading to unnecessary countermeasures. Here, we report a “positive” nucleic acid test on a 10-pooled sample during the routine screening that caused many adverse societal effects, and financial and resource losses. However, they were subsequently determined to be a case of vaccine contamination. This case study increases awareness of false-positive RT-PCR results for SARS-CoV-2, especially when participants are vaccinators. Moreover, it could provide relevant suggestions to prevent the recurrence of such incidents.
Disqualification of Donor and Recipient Candidates From the Living Kidney Donation Program: Experience of a Single-Center in Germany
Authors: Grigorescu Melissa , Kemmner Stephan , Schönermarck Ulf , Sajin Isidora , Guenther Wolfgang , Cerqueira Tiago Lemos , Illigens Ben , Siepmann Timo , Meiser Bruno , Guba Markus , Fischereder Michael , Johannes Stangl Manfred
Published: June 2022

Background

Kidney transplantation is the best treatment option for patients with end-stage kidney disease (ESKD) with a superiority of graft survival after living kidney donation (LKD) compared to deceased donation. However, a large part of potential donors and recipients are ineligible for LKD. Here, we analyze the leading causes for disqualification of potential living donor-recipient pairs from the LKD program and the health-related consequences for ESKD patients excluded from the LKD program in a German transplant center.

Methods

In this single-center retrospective cohort study we evaluated all candidates (potential donors and recipients) presenting for assessment of LKD from 2012 to 2020 at our transplant center. Thereby we focused on candidates excluded from the LKD program. Main reasons for disqualification were categorized as medical (donor-related), psychosocial, immunological, recipient-related, and unknown.

Results

Overall, 601 donor-recipient pairs were referred to our transplant center for LKD assessment during the observation time. Out of those, 326 (54.2%) discontinued the program with 52 (8.7%) dropouts and 274 (45.6%) donor-recipient pairs being ineligible for LKD. Donor-related medical contraindications were the main reason for disqualification [139 out of 274 (50.7%) potential donors] followed by recipient-related contraindications [60 out of 274 (21.9%) of potential donor-recipient pairs]. Only 77 out of 257 (29.9%) potential recipients excluded from the LKD program received a kidney transplant afterward with a median waiting time of 2 (IQR: 1.0–4.0) years. Overall, 18 (7.0%) ESKD patients initially declined for LKD died in this period.

Conclusion

A large percentage of donor-recipient pairs are disqualified from the German LKD program, mostly due to medical reasons related to the donor and with partly severe consequences for the potential recipients. For these, alternative solutions that promptly enable kidney transplantation are essential for improving patient quality of life and survival.
Metagenomic Screening for Lipolytic Genes Reveals an Ecology-Clustered Distribution Pattern
Authors: Lu Mingji , Schneider Dominik , Daniel Rolf
Published: June 2022

Lipolytic enzymes are one of the most important enzyme types for application in various industrial processes. Despite the continuously increasing demand, only a small portion of the so far encountered lipolytic enzymes exhibit adequate stability and activities for biotechnological applications. To explore novel and/or extremophilic lipolytic enzymes, microbial consortia in two composts at thermophilic stage were analyzed using function-driven and sequence-based metagenomic approaches. Analysis of community composition by amplicon-based 16S rRNA genes and transcripts, and direct metagenome sequencing revealed that the communities of the compost samples were dominated by members of the phyla Actinobacteria, Proteobacteria, Firmicutes, Bacteroidetes, and Chloroflexi. Function-driven screening of the metagenomic libraries constructed from the two samples yielded 115 unique lipolytic enzymes. The family assignment of these enzymes was conducted by analyzing the phylogenetic relationship and generation of a protein sequence similarity network according to an integrated classification system. The sequence-based screening was performed by using a newly developed database, containing a set of profile Hidden Markov models, highly sensitive and specific for detection of lipolytic enzymes. By comparing the lipolytic enzymes identified through both approaches, we demonstrated that the activity-directed complements sequence-based detection, and vice versa. The sequence-based comparative analysis of lipolytic genes regarding diversity, function and taxonomic origin derived from 175 metagenomes indicated significant differences between habitats. Analysis of the prevalent and distinct microbial groups providing the lipolytic genes revealed characteristic patterns and groups driven by ecological factors. The here presented data suggests that the diversity and distribution of lipolytic genes in metagenomes of various habitats are largely constrained by ecological factors.
Early Serum Metabolism Profile of Post-operative Delirium in Elderly Patients Following Cardiac Surgery With Cardiopulmonary Bypass
Authors: Huang He , Han Jingjing , Li Yan , Yang Yonglin , Shen Jian , Fu Qiang , Chen Yu
Published: June 2022

Background

Cardiac surgery with cardiopulmonary bypass (CPB) is considered to be one of the surgical types with the highest incidence of post-operative delirium (POD). POD has been associated with a prolonged intensive care and hospital stay, long-term neurocognitive deterioration, and increased mortality. However, the specific pathogenesis of POD is still unclear. Untargeted metabolomics techniques can be used to understand the changes of serum metabolites in early POD to discover the relationship between serum metabolites and disease.

Materials and Methods

The present study recruited 58 elderly patients undergoing cardiac surgery with CPB. Serum was collected within the first 24 h after surgery. The Confusion Assessment Method (CAM) and ICU-CAM assessments were used to identify patients who experienced POD. All patients with normal post-operative cognitive assessment were included in the non-POD groups. Moreover, we collected serum from 20 healthy adult volunteers. We performed untargeted analyses of post-operative serum metabolites in all surgical groups, as well as serum metabolites in healthy non-surgical adults by using liquid chromatography mass spectrometry (LC/MS) and analyzed metabolic profiles and related metabolites.

Results

The probability of POD after cardiac surgery were 31%. There were statistically significant differences in post-operative mechanical ventilation time, ICU stay time and post-operative hospital stay between POD and non-POD group (P < 0.05). And ICU stay time was an independent risk factor for POD. The analysis revealed that a total of 51 differentially expressed metabolites (DEMs) were identified by comparing the POD and non-POD group, mostly lipids and lipid-like molecules. Three phosphatidylinositol (PI) were down-regulated in POD group, i.e., PI [18:0/18:2 (9Z, 12Z)], PI [20:4 (8Z, 11Z, 14Z, 17Z)/18:0], and PI [18:1 (9Z)/20:3 (8Z, 11Z, 14Z)]. The receiver operating characteristic (ROC) curve analysis showed that three kinds of PI metabolites had the highest area under the curve (AUC), which were 0.789, 0.781, and 0.715, respectively. Correlation analysis showed that the expression of three PIs was negatively correlated with the incidence of POD.

Conclusion

Our findings suggest that lipid metabolism plays an important role in the serum metabolic profile of elderly patients with POD in the early post-operative period. Low serum lipid metabolic PI was associated with incidence of POD in elderly following cardiac bypass surgery, which may provide new insights into the pathogenesis of POD.