bluuebunny/crossref_metadata_2025 huggingface dataset:
Basidiomycetes Polysaccharides Regulate Growth and Antioxidant Defense System in Wheat
Authors: Tsivileva Olga , Shaternikov Andrei , Evseeva Nina
Published: June 2024

Higher-fungi xylotrophic basidiomycetes are known to be the reservoirs of bioactive metabolites. Currently, a great deal of attention has been paid to the exploitation of mycelial fungi products as an innovative alternative in crop protection. No data exist on the mechanisms behind the interaction between xylotrophic mushrooms’ glycopolymeric substances and plants. In this study, the effects of basidiomycete metabolites on the morphophysiological and biochemical variables of wheat plants have been explored. Wheat (Triticum aestivum L. cv. Saratovskaya 29) seedlings were treated with extracellular polysaccharides (EPSs) isolated from the submerged cultures of twenty basidiomycete strains assigned to 13 species and 8 genera. The EPS solutions at final concentrations of 15, 40, and 80 mg/L were applied to wheat seedlings followed by their growth for 10 days. In the plant samples, the biomass, length of coleoptile, shoot and root, root number, rate of lipid peroxidation by malondialdehyde concentration, content of hydrogen peroxide, and total phenols were measured. The peroxidase and superoxide dismutase activity were defined. Most of the EPS preparations improved biomass yields, as well as the morphological parameters examined. EPS application enhanced the activities of antioxidant enzymes and decreased oxidative damage to lipids. Judging by its overall effect on the growth indices and redox system of wheat plants, an EPS concentration of 40 mg/L has been shown to be the most beneficial compared to other concentrations. This study proves that novel bioformulations based on mushroom EPSs can be developed and are effective for wheat growth and antioxidative response. Phytostimulating properties found for EPSs give grounds to consider extracellular metabolites produced in the xylotrophic basidiomycete cultures as an active component capable of inducing plant responses to stress.
First Examples of s-Metal Complexes with Subporphyrazine and Its Phenylene-Annulated Derivatives: DFT Calculations
Authors: Chachkov Denis V. , Mikhailov Oleg V. , Girichev Georgiy V.
Published: June 2024

Using quantum chemical calculation data obtained by the DFT method with the B3PW91/TZVP and M062X/def2TZVP theory levels, the possibility of the existence of four Be(II) coordination compounds, each of which contains in the inner coordination sphere and the double deprotonated forms of subporphyrazine (H2SP), mono[benzo]subporphyrazine (H2MBSP), di[benzo]subporphyrazine (H2DBSP), and tri[benzo]subporphyrazine (subphthalocyanine) (H2TBSP) with a ratio Be(II) ion/ligand = 1:1, were examined Selected geometric parameters of the molecular structures of these (666)macrotricyclic complexes with closed contours are given; it was noted that BeN3 chelate nodes have a trigonal–pyramidal structure and exhibit a very significant (almost 30°) deviation from coplanarity; however, all three 6-membered metal-chelate and three 5-membered non-chelate rings in each of these compounds are practically planar and deviate from coplanarity by no more than 2.5°. The bond angles between two nitrogen atoms and a Be atom are equal to 60° (in the [BeSP] and [BeTBSP]) or less by no more than 0.5° (in the [BeMBSP] and [BeDBSP]). The presence of annulated benzo groups has little effect on the parameters of the molecular structures of these complexes. Good agreement between the structural data obtained using the above two versions of the DFT method was noticed. NBO analysis data for these complexes are presented; it was noted that, according to both DFT methods used, the ground state of the each of complexes under study is a spin singlet. Standard thermodynamic parameters of formation (standard enthalpy ΔfH0, entropy S0, and Gibbs free energy ΔfG0) for the above-mentioned macrocyclic compounds were calculated.
Environmental Enrichment Prevents Gut Dysbiosis Progression and Enhances Glucose Metabolism in High-Fat Diet-Induced Obese Mice
Authors: Manzo Rubiceli , Gallardo-Becerra Luigui , Díaz de León-Guerrero Sol , Villaseñor Tomas , Cornejo-Granados Fernanda , Salazar-León Jonathan , Ochoa-Leyva Adrian , Pedraza-Alva Gustavo , Pérez-Martínez Leonor
Published: June 2024

Obesity is a global health concern implicated in numerous chronic degenerative diseases, including type 2 diabetes, dyslipidemia, and neurodegenerative disorders. It is characterized by chronic low-grade inflammation, gut microbiota dysbiosis, insulin resistance, glucose intolerance, and lipid metabolism disturbances. Here, we investigated the therapeutic potential of environmental enrichment (EE) to prevent the progression of gut dysbiosis in mice with high-fat diet (HFD)-induced metabolic syndrome. C57BL/6 male mice with obesity and metabolic syndrome, continuously fed with an HFD, were exposed to EE. We analyzed the gut microbiota of the mice by sequencing the 16s rRNA gene at different intervals, including on day 0 and 12 and 24 weeks after EE exposure. Fasting glucose levels, glucose tolerance, insulin resistance, food intake, weight gain, lipid profile, hepatic steatosis, and inflammatory mediators were evaluated in serum, adipose tissue, and the colon. We demonstrate that EE intervention prevents the progression of HFD-induced dysbiosis, reducing taxa associated with metabolic syndrome (Tepidimicrobium, Acidaminobacteraceae, and Fusibacter) while promoting those linked to healthy physiology (Syntrophococcus sucrumutans, Dehalobacterium, Prevotella, and Butyricimonas). Furthermore, EE enhances intestinal barrier integrity, increases mucin-producing goblet cell population, and upregulates Muc2 expression in the colon. These alterations correlate with reduced systemic lipopolysaccharide levels and attenuated colon inflammation, resulting in normalized glucose metabolism, diminished adipose tissue inflammation, reduced liver steatosis, improved lipid profiles, and a significant reduction in body weight gain despite mice’s continued HFD consumption. Our findings highlight EE as a promising anti-inflammatory strategy for managing obesity-related metabolic dysregulation and suggest its potential in developing probiotics targeting EE-modulated microbial taxa.
19F-NMR Probing of Ion-Induced Conformational Changes in Detergent-Solubilized and Nanodisc-Reconstituted NCX_Mj
Authors: Nguyen Khiem , Strauss Tali , Refaeli Bosmat , Hiller Reuben , Vinogradova Olga , Khananshvili Daniel
Published: June 2024

Consecutive interactions of 3Na+ or 1Ca2+ with the Na+/Ca2+ exchanger (NCX) result in an alternative exposure (access) of the cytosolic and extracellular vestibules to opposite sides of the membrane, where ion-induced transitions between the outward-facing (OF) and inward-facing (IF) conformational states drive a transport cycle. Here, we investigate sub-state populations of apo and ion-bound species in the OF and IF states by analyzing detergent-solubilized and nanodisc-reconstituted preparations of NCX_Mj with 19F-NMR. The 19F probe was covalently attached to the cysteine residues at entry locations of the cytosolic and extracellular vestibules. Multiple sub-states of apo and ion-bound species were observed in nanodisc-reconstituted (but not in detergent-solubilized) NCX_Mj, meaning that the lipid-membrane environment preconditions multiple sub-state populations toward the OF/IF swapping. Most importantly, ion-induced sub-state redistributions occur within each major (OF or IF) state, where sub-state interconversions may precondition the OF/IF swapping. In contrast with large changes in population redistributions, the sum of sub-state populations within each inherent state (OF or IF) remains nearly unchanged upon ion addition. The present findings allow the further elucidation of structure–dynamic modules underlying ion-induced conformational changes that determine a functional asymmetry of ion access/translocation at opposite sides of the membrane and ion transport rates concurring physiological demands.
Purine-Rich Element Binding Protein Alpha, a Nuclear Matrix Protein, Has a Role in Prostate Cancer Progression
Authors: Inoue Takahiro , Bao Xin , Kageyama Takumi , Sugino Yusuke , Sekito Sho , Miyachi Shiori , Sasaki Takeshi , Getzenberg Robert
Published: June 2024

Solid tumors as well as leukemias and lymphomas show striking changes in nuclear structure including nuclear size and shape, the number and size of nucleoli, and chromatin texture. These alterations have been used in cancer diagnosis and might be related to the altered functional properties of cancer cells. The nuclear matrix (NM) represents the structural composition of the nucleus and consists of nuclear lamins and pore complexes, an internal ribonucleic protein network, and residual nucleoli. In the nuclear microenvironment, the NM is associated with multi-protein complexes, such as basal transcription factors, signaling proteins, histone-modifying factors, and chromatin remodeling machinery directly or indirectly through scaffolding proteins. Therefore, alterations in the composition of NM could result in altered DNA topology and changes in the interaction of various genes, which could then participate in a cascade of the cancer process. Using an androgen-sensitive prostate cancer cell line, LNCaP, and its androgen-independent derivative, LN96, conventional 2D-proteomic analysis of the NM proteins revealed that purine-rich element binding protein alpha (PURα) was detected in the NM proteins and differentially expressed between the cell lines. In this article, we will review the potential role of the molecule in prostate cancer.
The Current State of Knowledge Regarding the Genetic Predisposition to Sports and Its Health Implications in the Context of the Redox Balance, Especially Antioxidant Capacity
Authors: Sutkowy Paweł , Modrzejewska Martyna , Porzych Marta , Woźniak Alina
Published: June 2024

The significance of physical activity in sports is self-evident. However, its importance is becoming increasingly apparent in the context of public health. The constant desire to improve health and performance suggests looking at genetic predispositions. The knowledge of genes related to physical performance can be utilized initially in the training of athletes to assign them to the appropriate sport. In the field of medicine, this knowledge may be more effectively utilized in the prevention and treatment of cardiometabolic diseases. Physical exertion engages the entire organism, and at a basic physiological level, the organism’s responses are primarily related to oxidant and antioxidant reactions due to intensified cellular respiration. Therefore, the modifications involve the body adjusting to the stresses, especially oxidative stress. The consequence of regular exercise is primarily an increase in antioxidant capacity. Among the genes considered, those that promote oxidative processes dominate, as they are associated with energy production during exercise. What is missing, however, is a look at the other side of the coin, which, in this case, is antioxidant processes and the genes associated with them. It has been demonstrated that antioxidant genes associated with increased physical performance do not always result in increased antioxidant capacity. Nevertheless, it seems that maintaining the oxidant–antioxidant balance is the most important thing in this regard.
Mark–Release–Recapture (MRR) of Sterile Male Aedes albopictus (Skuse) in Sri Lanka: Field Performance of Sterile Males and Estimation of the Wild Mosquito Population Density
Authors: Hapugoda Menaka , Gunawardena Nilmini Silva , Ranathunge Tharaka , Bouyer Jeremy , Maiga Hamidou , Karunathilake Kankanige , Withanage Gayan Parakrama , Weerasinghe Indika , Sow Bazoumana B. D. , Harishchandra Jeevanie
Published: June 2024

Dengue is an important mosquito-borne disease in Sri Lanka. The Sterile Insect Technique (SIT) is an environment-friendly and novel method that can suppress dengue vector mosquitoes in Sri Lanka. This study aimed to evaluate the field performance of sterile males and the density of wild male Aedes albopictus (Skuse) using a Mark–Release–Recapture (MRR) assay. Laboratory-colonized male pupae were exposed to 50 Gy gamma using a Co60 source. Sterile males (approx. 10,000) marked with fluorescent dust were released weekly for 4 consecutive weeks (January–February 2021) in a geographically isolated 30 ha site in Gampaha. Results show sterile males could disperse up to 543.8 m with a mean distance of 255.1 ± 44.6 m and survive up to 6 days with a mean life expectancy of 3.55 ± 2.32 days. A high field mating competitiveness of sterile males based on a Fried value of 0.47 ± 0.007 and significant induced sterility in the wild eggs in the second generation were found. The mean wild male mosquito population density was 163 males/ha. The data generated will be useful for designing future trials in Sri Lanka and other countries with similar situations.
The Current Status of Minimally Invasive Conduit Harvesting for Coronary Artery Bypass Grafting
Authors: Anderson Devon , Kiaii Bob , Catrip Jorge
Published: June 2024

The harvesting of conduits for coronary artery bypass surgery has evolved over the last decade to include endoscopic approaches to access the saphenous vein, radial artery, and internal mammary artery. These minimally invasive techniques reduce the morbidity associated with open procedures by decreasing pain and recovery time and increasing mobility post operatively. This review highlights the differences in morbidity, quality, and patency between the most common conduits that are harvested minimally invasively for coronary artery bypass grafting surgery.
Pyoderma Gangrenosum, a Challenging Postpartum Diagnosis—Case Report and Literature Review
Authors: Matasariu Daniela Roxana , Bujor Iuliana Elena , Mihălceanu Elena , Gîscă Tudor Cătălin , Stâncanu Alina , Andriescu Elena Corina , Popescu Ioana , Socolov Demetra , Vasiluță Ciprian , Ursache Alexandra
Published: June 2024

Background/Objectives: The infrequent occurrence of pyoderma gangrenosum (PG) during pregnancy and in postpartum, with its subsequent diagnostic intricacies, caused us to present the following case. Methods: This article describes a rare case of PG in postpartum in a patient without any prior pathology and a short review of the literature, aiming to identify similar rare instances. Results: We conducted a literature review to ascertain the prevalence of postpartum pyoderma gangrenosum, and we identified a total of 41 cases. Conclusions: Our article underlines again the importance of interdisciplinary collaboration for the prompt identification and commencement of necessary therapeutic interventions in postpartum women afflicted by pyoderma gangrenosum.
Pulmonary Function Tests: Easy Interpretation in Three Steps
Authors: Ora Josuel , Giorgino Federica Maria , Bettin Federica Roberta , Gabriele Mariachiara , Rogliani Paola
Published: June 2024

Pulmonary function tests (PFTs) are pivotal in diagnosing and managing a broad spectrum of respiratory disorders. These tests provide critical insights into lung health, guiding diagnoses, assessing disease severity, and shaping patient management strategies. This review addresses the complexities and nuances inherent in interpreting PFT data, particularly in light of recent updates from the European Respiratory Society (ERS) and American Thoracic Society (ATS). These updates have refined interpretive strategies, moving away from definitive diagnostic uses of spirometry to a more probabilistic approach that better accounts for individual variability through the use of Z-scores and lower limits of normal (LLNs). Significantly, this narrative review delves into the philosophical shift in spirometry interpretation, highlighting the transition from direct clinical diagnostics to a more nuanced evaluation geared towards determining the likelihood of disease. It critiques the reliance on fixed ratios and emphasizes the need for reference values that consider demographic variables such as age, sex, height, and ethnicity, in line with the latest Global Lung Function Initiative (GLI) equations. Despite these advances, challenges remain in ensuring uniformity across different predictive models and reference equations, which can affect the accuracy and consistency of interpretations. This paper proposes a streamlined three-step framework for interpreting PFTs, aiming to unify and simplify the process to enhance clarity and reliability across various medical specialties. This approach not only aids in accurate patient assessments but also mitigates the potential for misdiagnosis and ensures more effective patient management. By synthesizing contemporary guidelines and integrating robust physiological principles, this review fosters a standardized yet flexible approach to PFT interpretation that is both scientifically sound and practically feasible.
Peripheral Artery Disease among a High-Risk Asian Population with Ischaemic Stroke, Cardiovascular Disease, or Diabetes Mellitus
Authors: Venketasubramanian Narayanaswamy , Mak Koon Hou , Loh Keh Chuan , Tan John
Published: June 2024

Background: Peripheral artery disease (PAD) affects more than 100 million people globally. Most PAD studies have been performed among predominantly White populations—less is known about other ethnicities. The aim of this cross-sectional study was to determine the prevalence and risk factors of PAD in a high-risk Asian population with ischaemic stroke (IS), myocardial infarction, unstable angina (CVD), or diabetes mellitus (DM). Methods: Patients admitted for IS, CVD, or DM were recruited. Data were collected on age, sex, body mass index (BMI), index condition (CVD, IS, DM), history of hypertension, DM, hypercholesterolaemia, cigarette smoking, and claudication. The Edinburgh Claudication Questionnaire was administered, the ankle brachial index (ABI) was determined, and PAD was diagnosed if ABI was ≤0.9. Results: Of the 450 subjects recruited, 150 were placed in each index disease group, the mean age was 61.9 ± 10.32 years, 43.1% were female, and the mean BMI was 23.9 ± 4.3. Hypertension was reported in 59.3%, DM in 63.6%, hypercholesterolaemia in 39.6%, and smoking in 42.9% of patients. The prevalence of PAD was 27.1%, 22.0% in IS, 29.3% in CAD, and 30.0% in DM. PAD was associated with increasing age (adjusted odds ratio (aOR) 1.04/year, 95% confidence interval [CI] 1.01–1.06; p < 0.001), reduced BMI (aOR 0.94, 95% CI 0.89–0.99; p = 0.026), DM (aOR 1.59, 95% CI 1.20–3.18; p = 0.007), and hypercholesterolaemia (aOR 1.82, 95% CI 1.17–2.28; p = 0.007). It was more frequent in non-lacunar versus lacunar acute IS, non-ST segment elevation versus ST-segment elevation acute myocardial infarction, and insulin-treated versus non-insulin-treated DM. Conclusions: Our study showed a high prevalence of PAD among high-risk Asian patients. This was associated with increasing age, DM, and hypercholesterolaemia and inversely associated with BMI. Different rates were found in sub-groups of IS, CVD, and DM. Systematic approaches were used to identify these high-risk individuals and to improve their outcomes.
Traumatic Brain Injury in Patients under Anticoagulant Therapy: Review of Management in Emergency Department
Authors: Menditto Vincenzo G. , Rossetti Giulia , Sampaolesi Mattia , Buzzo Marta , Pomponio Giovanni
Published: June 2024

The best management of patients who suffer from traumatic brain injury (TBI) while on oral anticoagulants is one of the most disputed problems of emergency services. Indeed, guidelines, clinical decision rules, and observational studies addressing this topic are scarce and conflicting. Moreover, relevant issues such as the specific treatment (and even definition) of mild TBI, rate of delayed intracranial injury, indications for neurosurgery, and anticoagulant modulation are largely empiric. We reviewed the most recent evidence on these topics and explored other clinically relevant aspects, such as the promising role of dosing brain biomarkers, the strategies to assess the extent of anticoagulation, and the indications of reversals and tranexamic acid administration, in cases of mild TBI or as a bridge to neurosurgery. The appropriate timing of anticoagulant resumption was also discussed. Finally, we obtained an insight into the economic burden of TBI in patients on oral anticoagulants, and future directions on the management of this subpopulation of TBI patients were proposed. In this article, at the end of each section, a “take home message” is stated.
Biocomposite Based on Polyhydroxybutyrate and Cellulose Acetate for the Adsorption of Methylene Blue
Authors: Villabona-Ortíz Ángel , Ortega-Toro Rodrigo , Pedroza-Hernández Jenyfer
Published: June 2024

Industrialization and globalization have caused severe environmental problems, such as contaminating water bodies by toxic agents from various industries, generating a significant loss of biodiversity and health risks. Globally, approximately 80% of wastewater is discharged without treatment, worsening the situation. However, in Colombia, initiatives have been taken to improve wastewater management, with ambitious investments and targets to improve treatment infrastructure. Recently, advanced technologies have been developed to treat wastewater, including more efficient and sustainable biological methods, such as using coconut-derived adsorbent biomaterials, rich in useful properties for the adsorption of pollutants in solutions. This research focuses on developing a composite biomaterial using cellulose acetate (CA) extracted from coconut mesocarp and polyhydroxy butyrate (PHB), by the casting method, to treat wastewater. Adsorption tests with the tracer methylene blue (MB) were carried out in the Energy and Environment laboratory of the University of Cartagena. For this, MB solutions were prepared with 5 to 50 ppm concentrations. The analyses showed that the composite biomaterial is thermally stable and has good homogeneity and porosity. At a concentration of 40 ppm and a dosage of 10 mg of adsorbent, the adsorption efficiency was 89%, with an adsorption capacity of 35.98 mg/g. The above indicates that the composite biomaterial is presented as a sustainable, improved, and efficient solution to remove contaminants from wastewater, benefiting the environment and human health.
Effect of Shade and Light-Curing Intensity on Bulk-Fill Composite: Heat Generation and Chemo-Mechanical Properties (In Vitro Study)
Authors: Hussein Hawkar Abdalla , Saeed Hawzhen Masoud M.
Published: June 2024

The aim of this study is to assess the effect of shade and light-curing intensity on the heat generation and degree of conversion of bulk-fill composite. A commercially available bulk-fill composite resin was used in this study. A total of 250 cylindrical specimens of each composite shade (n = 25/group) were prepared (125 for testing heat generation and 125 for testing degree of conversion, then cured using a monowave light-curing unit (LCU) with a single light intensity of 1470 mW/cm2 and a polywave LCU with three different light intensities (1200, 2000, and 3000 mW/cm2). Heat generation during polymerization was measured by five K-type thermocouples placed in each 1 mm layer from top to bottom. FTIR was used for evaluating the degree of conversion. Regarding heat generation, significant differences were seen in layers 4 and 5. Curing types and times also showed significant impacts on heat generation and the degree of conversion. Heat generation relates more to curing time than light intensity. Darker shades generate and retain more heat. Lighter shades exhibit higher degrees of conversion with longer curing.
Efficient Wheat Head Segmentation with Minimal Annotation: A Generative Approach
Authors: Myers Jaden , Najafian Keyhan , Maleki Farhad , Ovens Katie
Published: June 2024

Deep learning models have been used for a variety of image processing tasks. However, most of these models are developed through supervised learning approaches, which rely heavily on the availability of large-scale annotated datasets. Developing such datasets is tedious and expensive. In the absence of an annotated dataset, synthetic data can be used for model development; however, due to the substantial differences between simulated and real data, a phenomenon referred to as domain gap, the resulting models often underperform when applied to real data. In this research, we aim to address this challenge by first computationally simulating a large-scale annotated dataset and then using a generative adversarial network (GAN) to fill the gap between simulated and real images. This approach results in a synthetic dataset that can be effectively utilized to train a deep-learning model. Using this approach, we developed a realistic annotated synthetic dataset for wheat head segmentation. This dataset was then used to develop a deep-learning model for semantic segmentation. The resulting model achieved a Dice score of 83.4% on an internal dataset and Dice scores of 79.6% and 83.6% on two external datasets from the Global Wheat Head Detection datasets. While we proposed this approach in the context of wheat head segmentation, it can be generalized to other crop types or, more broadly, to images with dense, repeated patterns such as those found in cellular imagery.
First Data on the Investigation of Gut Yeasts in Hermit Beetle (Osmoderma barnabita Motschulsky, 1845) Larvae in Lithuania
Authors: Švedienė Jurgita , Raudonienė Vita , Mizerienė Goda , Rimšaitė Jolanta , Davenis Sigitas Algis , Ivinskis Povilas
Published: June 2024

In this study, yeasts from the gut of O. barnabita larvae were isolated and molecularly identified. It is worth noting that this research provides the first analysis of the gut yeast community in O. barnabita larvae in Lithuania, which is a significant contribution to the field. Two hermit-like L3-praepupa instars were collected from a decaying oak log in Lithuania. The isolation, morphology, biochemistry, and physiology of the yeast isolates were characterized using standards commonly employed in yeast taxonomy studies. The isolates were identified by sequencing the large subunit (26S) rDNA (D1/D2 domain of the LSU). All gut compartments were colonized by the yeast. A total of 45 yeast strains were obtained from the gut of both O. barnabita larvae, with 23 strains originating from Larva 1, 16 strains from Larva 2, and 6 strains from the galleries. According to our identification results of the 45 yeast strains, most of the species were related to Ascomycota, with most of them belonging to the Saccharomycetales order. Yeasts of the genera Candida, Debaryomyces, Meyerozyma, Priceomyces, Schwanniomyces, Spencermartinsiella, Trichomonascus, and Blastobotrys were present in gut of O. barnabita larvae. Species of the Trichosporonales order represented the Basidiomycota phylum.
Transforming Ontology Web Language Elements into Common Terminology Service 2 Terminology Resources
Authors: Mora Sara , Gazzarata Roberta , Blobel Bernd , Murgia Ylenia , Giacomini Mauro
Published: June 2024

Communication and cooperation are fundamental for the correct deployment of P5 medicine, and this can be achieved only by correct comprehension of semantics so that it can aspire to medical knowledge sharing. There is a hierarchy in the operations that need to be performed to achieve this goal that brings to the forefront the complete understanding of the real-world business system by domain experts using Domain Ontologies, and only in the last instance acknowledges the specific transformation at the pure information and communication technology level. A specific feature that should be maintained during such types of transformations is versioning that aims to record the evolution of meanings in time as well as the management of their historical evolution. The main tool used to represent ontology in computing environments is the Ontology Web Language (OWL), but it was not created for managing the evolution of meanings in time. Therefore, we tried, in this paper, to find a way to use the specific features of Common Terminology Service—Release 2 (CTS2) to perform consistent and validated transformations of ontologies written in OWL. The specific use case managed in the paper is the Alzheimer’s Disease Ontology (ADO). We were able to consider all of the elements of ADO and map them with CTS2 terminological resources, except for a subset of elements such as the equivalent class derived from restrictions on other classes.
Urban Geomorphology Methods and Applications as a Guideline for Understanding the City Environment
Authors: Pica Alessia , Lämmle Luca , Burnelli Martina , Del Monte Maurizio , Donadio Carlo , Faccini Francesco , Lazzari Maurizio , Mandarino Andrea , Melelli Laura , Perez Filho Archimedes , Russo Filippo , Stamatopoulos Leonidas , Stanislao Corrado , Brandolini Pierluigi
Published: June 2024

Cities all over the world have developed on different geological-geomorphological substrates. Different kinds of human activities have operated for millennia as geomorphic agents, generating numerous and various erosion landforms and huge anthropogenic deposits. Considering the increasing demand for land and the expansion of the built-up areas involving and disturbing any kind of natural system inside and surrounding the actual urban areas, it is not negligible how important the dynamics of the urban environment and its physical evolution are. In this context, this manuscript addresses insights into eight case studies of urban geomorphological analyses of cities in Italy, Greece, and Brazil. The studies are based on surveying and mapping geomorphological processes and landforms in urban areas, supporting both geo-hazard assessment, historical evolution, and paleomorphologies, as well as disseminating knowledge of urban geoheritage and educating about the anthropogenic impact on urban sustainability. We hypothesize that urban geomorphological analysis of several case studies addresses the physical environment of modern cities in a multi-temporal, multidisciplinary, and critical way concerning global changes. Thus, this study aims to illustrate and propose a novel approach to urban geomorphological investigation as a model for the understanding and planning of the physical urban environment on a European and global scale.
Revealing Topsoil Behavior to Compaction from Mining Field Observations
Authors: Richer-de-Forges Anne C. , Arrouays Dominique , Libohova Zamir , Chen Songchao , Beaudette Dylan E. , Bourennane Hocine
Published: June 2024

Soils are a finite resource that is under threat, mainly due to human pressure. Therefore, there is an urgent need to produce maps of soil properties, functions and behaviors that can support land management and various stakeholders’ decisions. Compaction is a major threat to soil functions, such as water infiltration and storage, and crops’ root growth. However, there is no general agreement on a universal and easy-to-implement indicator of soil susceptibility to compaction. The proposed indicators of soil compaction require numerous analytical determinations (mainly bulk density measurements) that are cost prohibitive to implement. In this study, we used data collected in numerous in situ topsoil observations during conventional soil survey and compared field observations to usual indicators of soil compactness. We unraveled the relationships between field estimates of soil compactness and measured soil properties. Most of the quantitative indicators proposed by the literature were rather consistent with the ordering of soil compactness classes observed in the field. The best relationship was obtained with an indicator using bulk density and clay (BDr2) to define three classes of rooting limitation. We distinguished six clusters of topsoil behaviors using hierarchical clustering. These clusters exhibited different soil behaviors to compaction that were related to soil properties, such as particle-size fractions, pH, CaCO3 and organic carbon content, cation exchange capacity, and some BDr2 threshold values. We demonstrate and discuss the usefulness of field observations to assess topsoil behavior to compaction. The main novelty of this study is the use of large numbers of qualitative field observations of soil profiles and clustering to identify contrasting behavior. To our knowledge, this approach has almost never been implemented. Overall, analysis of qualitative and quantitative information collected in numerous profiles offers a new way to discriminate some broad categories of soil behavior that could be used to support land management and stakeholders’ decisions.
Back to the Village: Assessing the Effects of Naturalness, Landscape Types, and Landscape Elements on the Restorative Potential of Rural Landscapes
Authors: Shen Hanbin , He Xuecong , He Jing , Li Danming , Liang Mingjie , Xie Xubin
Published: June 2024

Rural landscapes are acknowledged for their potential to restore human health due to natural characteristics. However, modern rural development has degraded these environments, thereby diminishing the restorative potential of rural landscapes. Few studies have systematically analyzed the impact of naturalness, landscape types, and landscape elements on restorativeness using both subjective and objective measurements. This study investigated the restorative effects of various rural landscapes in Guangzhou, employing electroencephalography and eye-tracking technologies to record physiological responses and using the Restorative Components Scale and the Perceived Restorativeness and Naturalness Scale to evaluate psychological responses. The results indicated the following: (1) There was a significant positive correlation between perceived naturalness and restorativeness, surpassing the impact of actual naturalness. (2) Different landscape types had varying impacts on restorativeness at the same level of perceived naturalness. Natural forest landscapes, artificial forest landscapes, and settlement landscapes exhibited the most substantial restorative effects among the natural, semi-natural, and artificial landscapes examined, respectively. (3) Restorative properties varied across landscape elements: trees and water significantly enhanced restorativeness, whereas constructed elements reduced it. Findings from this study can provide support for policymakers to make informed decisions regarding the selection and arrangement of rural landscape types and elements to enhance mental health and well-being.
“It Will Be a Desert”: Extreme Weather and the Effects of Climate Catastrophe on Vulnerable Riparian Spaces in Nairobi, Kenya
Authors: Howland Olivia
Published: June 2024

Urban riparian spaces are notoriously vulnerable, and pressure on water resources is growing. In the context of a fast-growing urban population and a lack of state-level structures and services to deal with water and sanitation, these spaces—including both land and water—are rapidly being degraded. Ongata Rongai, a satellite town in the Nairobi Metropolitan Area, is one of these spaces. Traditional livelihoods exist cheek-by-jowl with modern life; livestock are watered at the rivers, lions frequent the riverbanks, large commercial farms extract water for crops, industrial factories release heavy metal contaminants into the rivers, and rapidly constructed poor-quality apartment blocks with no provision for human waste release untreated sewage and dump trash into the rivers. Compounding these anthropogenic impacts is that of climate change. Riparian spaces have become sites where humans and animals fight for access to water and riparian space, and rain becomes less reliable or frequent, yet at other times, these spaces experience flash flooding and catastrophic water levels leading to the destruction of land. This study explores the dynamics of a rapidly changing riparian environment which finds itself dominated by urbanity, under the increasing pressure of anthropogenic climate change using a One Health perspective. This study contributes much needed human voices to a growing body of literature led by indigenous Kenyan scholars, calling for urgent structural level action to conserve urban riparian zones for the benefit of human and non-human actors.
Towards Just and Integrated Energy Transition in Taiwan: A Socio-Spatial Perspective
Authors: Liu Kuan-Ting , Dąbrowski Marcin
Published: June 2024

Energy justice remains relatively under-researched outside of the Western context, especially in Asia. This paper addresses that gap by investigating the process of energy transition in Taiwan through the socio-spatial lens and institutional points of view. The paper underscores the urgency of recognizing and addressing the overlooked social injustices across different territories, advocating an integrated planning approach that incorporates a just energy transition perspective to reduce the uneven negative impacts of deploying renewable energies across communities and regional territories. Drawing on a case study of the Changhua region, the paper identifies conflicts arising from the rapid deployment of renewable energy, such as land use changes that displace farming activities and negatively affect rural stakeholders. The findings suggest the need to urgently address the gap between top–down goals in energy transition and bottom–up considerations to raise awareness and prevent injustices that risk deepening the existing socio-economic inequities. This paper also proposes a new framework for both new research and policy for (just) energy transition, incorporating distributional, procedural, and recognitional concerns together with a critical view on the cross-scale and cross-sectoral integration as part of the spatial planning process.
Cultural–Cognitive Study of Selected Death-Oriented Personal Names in Igbo
Authors: Kamalu Ikenna , Onumonu Ugo P. , Udisi Arnold Stanley
Published: June 2024

Working chiefly within the tenets of Cultural Linguistics (CL), this study examines the cultural and cognitive motivations that underlie selected death-oriented personal names among the Igbo of South-eastern Nigeria. Based on the cultural linguistic perspective, the analytical tool for the study is shaped by insights from cultural schemas, cultural categories and cultural metaphors as signifiers of ideation and social meaning. The cultural frames enable the language user to have a better understanding of the cultural and cognitive motivations that underlie the conceptualization of names and naming among the Igbo. Much has been done on the structure and sociological forms of Igbo personal names and their meanings, but only a few studies have been undertaken on the names that express the notions of death and dying in Igbo. More importantly, no previous study has used insights from Cultural Linguistics (CL) or the Conceptual Metaphor Theory (CMT) to explain the motivations for the preponderance of death-oriented names among the Igbo people. Thus, this study specifically aims to address the lacuna. The study reveals that the Igbo, like most African and other human societies, recognize and accept the inevitability of death. Consequently, they use language in diverse forms and contexts to express their perceptions of the horrors and pains associated with the inevitability of death. Songs, proverbs and ritual practices are some of the verbal and social semiotic forms through which the Igbo express their knowledge of and attitude toward death and dying. However, names and naming are the most vivid cultural cognitive patterns by which the Igbo show their understanding of the nature of death and dying and their psychological effects on the living. Constrained by space and scope, this study identified and classified six major death-oriented names among the Igbo, as follows: names that depict the overwhelming power of death; names that make an appeal to death; names that depict death as wicked/evil/terror; names that depict death as no respecter of wealth/social class; names that challenge/mock the assumed power of death; and names that depict death as an insensitive entity. Thus, the above frames constitute the major paradigms by which the Igbo express their knowledge of and attitudes toward death and dying.
Variable Acceptability of Differential Object Marking in Bilingual Galician–Spanish Speakers: An Exploratory Study
Authors: Delicado Cantero Manuel , Parafita Couto M. Carmen
Published: June 2024

This paper presents an initial study of the acceptability of differential object marking (DOM) by Galician–Spanish bilinguals in Galicia. The research explores judgments provided by these bilinguals (n = 69) on DOM in both Galician and Spanish and it also explores data from a monolingual Spanish control group (n = 12). The surveys target contexts covering key syntactic and semantic–pragmatic contexts for DOM in Galician and Spanish, based on the existing literature. The Galician data reveal a tendency towards reduced acceptability of DOM compared to Spanish, but without a generalized rejection of DOM in any of the contexts. The Spanish data show variability in both groups. The study contributes insights from an under-studied language pair and aims to open avenues for further work. More generally, it enhances our understanding of DOM in bilingual grammars, particularly in microcontact situations.
Intravesical Gemcitabine and Docetaxel Therapy for BCG-Naïve Patients: A Promising Approach to Non-Muscle Invasive Bladder Cancer
Authors: Bakula Mirko , Hudolin Tvrtko , Knezevic Nikola , Zimak Zoran , Andelic Jerko , Juric Ilija , Gamulin Marija , Gnjidic Milena , Kastelan Zeljko
Published: June 2024

Bacillus Calmette-Guérin (BCG) therapy for patients with non-muscle invasive bladder cancer (NMIBC) faces limitations in efficacy and significant side effects, aggravated by a recent global shortage. In this prospective clinical study, we report the outcomes of sequential intravesical administration of gemcitabine and docetaxel (Gem/Doce) as a first-line treatment for BCG-naïve patients with high-risk NMIBC (HR NMIBC). From October 2019 until April 2022, we enrolled 52 patients and followed the treatment protocol set forth by the University of Iowa. Follow-up assessments were conducted every 3 months. In this cohort, 25 (48.1%) patients were diagnosed with high-grade T1 (T1HG) bladder cancer, 10 (19.2%) patients had carcinoma in situ (CIS), and 17 (32.7%) patients had a combination of T1HG+CIS. The median time to first recurrence in the T1HG, CIS, and T1HG+CIS groups was 11, 10.5, and 8.8 months, respectively. The recurrence-free survival was 98.1%, 94.2%, and 80.8% at 6, 9, and 12 months, respectively. The rate of progression-free survival was 100%, 98.1%, and 92.3% at 6, 9, and 12 months, respectively. We demonstrated the safety and efficacy of Gem/Doce therapy in BCG-naïve patients with HR NMIBC during a one-year follow-up. Further research with extended follow-ups, as well as direct comparisons of Gem/Doce with other anticancer agents, is essential.
Self-Generated Lower Body Negative Pressure Exercise: A Low Power Countermeasure for Acute Space Missions
Authors: Velichala Suhas , Kassel Ryan , Ly Victoria , Watenpaugh Donald , Lee Stuart , Macias Brandon , Hargens Alan
Published: June 2024

Microgravity in spaceflight produces headward fluid shifts which probably contribute to Spaceflight-Associated Neuro-Ocular Syndrome (SANS). Developing new methods to mitigate these shifts is crucial for preventing SANS. One possible strategy is the use of self-generated lower body negative pressure (LBNP). This study evaluates biological or physiological effects induced by bed rest to simulate adaptations to microgravity. Participants were tested during powered LBNP and dynamic self-generated (SELF) LBNP at 25 mmHg for 15 min. The results were compared to the physiologic responses observed in seated upright and supine positions without LBNP, which served as controls for normal gravitational effects on fluid dynamics. Eleven participants’ (five male, six female) heart rates, blood pressures, and cross-sectional areas (CSA) of left and right internal jugular veins (IJV) were monitored. Self-generated LBNP, which requires mild to moderate physical activity, significantly elevated heart rate and blood pressure (p < 0.01). Self-generated LBNP also significantly reduced right IJV CSA compared to supine position (p = 0.005), though changes on the left side were not significant (p = 0.365). While the effects of SELF and traditional LBNP on IJV CSA were largely similar, traditional LBNP significantly reduced IJV CSA on both sides. Given its low mass, volume, and power requirements, SELF LBNP is a promising countermeasure against SANS. Results from this study warrant longer-term studies of SELF LBNP under simulated spaceflight conditions.
Structural Elucidation of a New Puzzling Compound Emerged from Doebner Quinoline Synthesis
Authors: Al-Matarneh Cristina Maria , Nicolescu Alina
Published: June 2024

The quinoline ring is found in many biologically active natural alkaloids and is still being highly exploited by researchers due to its numerous potential applications in fields ranging from pharmacology to material science. During our synthetic attempts for new quinoline-4-carboxylic acids, using an extended version of the Doebner reaction, a new puzzling compound emerged when para-iodine aniline was reacted with salicylaldehyde and pyruvic acid in acetic acid as a reaction medium. The chemical structure of this new compound was established based on the information obtained from 1D and 2D NMR experiments (1H-, 13C-, and 15N-NMR), corroborated with MS spectrometry and IR spectroscopy. The photophysical properties (UV–vis and fluorescence) were also investigated. The proposed structure contains as the main elements a 1,4-dioxane-2,5-dione core symmetrically substituted with a propylidene chain that has attached to it a salicylaldehyde fragment and a pyrrole-2-one ring containing two 4-iodophenyl fragments. The isolation of this compound, reported here for the first time, is direct evidence that unexpected compounds can emerge from “classical” synthetic pathways when the right components are combined.
Environmentally Friendly o–Cresol–Furfural–Formaldehyde Resin as an Alternative to Traditional Phenol–Formaldehyde Resins for Paint Industry
Authors: Depta Marta , Napiórkowski Sławomir , Zielińska Katarzyna , Gębura Katarzyna , Niewolik Daria , Jaszcz Katarzyna
Published: June 2024

This paper describes studies on the preparation of an o–cresol–furfural–formaldehyde resin in the presence of an alkaline catalyst and its modification with n-butanol or 2-ethylhexanol. The novelty of this research is to obtain a furfural-based resin of the resole type and its etherification. Such resins are not described in the literature and also are not available on the market. The obtained resin based on furfural, which can be obtained from agricultural waste, had a low minimum content of free o–cresol < 1 wt.%, furfural < 0.1 wt.%, and formaldehyde < 0.1 wt.%. The resin structure was characterized by mass spectrometry (ESI-MS), FT-IR, and NMR spectroscopy, which showed the presence of hydroxymethylene groups in the resin before modification and alkyl groups derived from n-butanol and 2-ethylhexanol after modification. The etherified resins had a lower viscosity and were more flexible (DSC) than the resin before modification and they can be used as an environmentally friendly, safe, and sustainable alternative to traditional phenol–formaldehyde resins in the paint industry. They demonstrate the ability to create a protective coating with good adherence to metal substrates and an excellent balance of flexibility and hardness.