bluuebunny/crossref_metadata_2025 huggingface dataset:
A preliminary, descriptive survey of rhotic and approximant fricativization in Northern Ecuadorian Andean Spanish varieties, Quichua, and Media Lengua
Authors: Stewart Jesse
Published: March 2020

This chapter examines acoustic data from six speech communities in the northern Andean region of Ecuador to describe variation in the Spanish rhotics /r, ɾ/ and approximants /ʎ, j/, as well as their relationship to the Quichua fricatives /ʐ, ʒ/. Data were collected from four dialects of Spanish, Imbabura Quichua, and Media Lengua, a mixed language containing Spanish lexicon and Quichua morphosyntax. Results from this preliminary, descriptive survey support claims that speakers of both urban and rural dialects of Spanish make extensive use of [ʐ] for /r/ and [ʒ] for /ʎ/, in addition to a wealth of phonetic variation. Similarly, /r/ and /ʎ/ from Spanish borrowings in Media Lengua and Quichua assimilate to [ʐ] and [ʒ], respectively, with little exception.
Spanish phonology in contact with Catalan
Authors: Davidson Justin
Published: March 2020

This study investigates sociophonetic variation in the production of the alveolar lateral /l/ in Catalan and Spanish, the velarization of which is considered the hallmark feature of Catalonian Spanish (Arnal, 2011; Casanovas Català, 1995; Hickey, 2012). Using an innovative combination of both gradient and categorical analyses to evaluate lateral production in Spanish and Catalan elicited from Catalan-Spanish bilinguals and Madrid monolinguals stratified by gender and exposure/usage of Catalan, we assess the degree to which lateral velarization pervades this contact setting. In so doing, we demonstrate that lateral velarization and the inventory of lateral categories in these languages are best approached using gradient and relative hierarchies of lateral darkness rather than discrete applications of intrinsically light [l] or dark [ɫ].
A conceptual framework for ex ante valuation of ecosystem services of brownfield greening from a systematic perspective
Authors: Zhong Qicheng , Zhang Lang , Zhu Yi , Konijnendijk van den Bosch Cecil , Han Jigang , Zhang Guilian , Li Yuezhong
Published: March 2020

Introduction:
Although Brownfield greening (BG) can be a crucial solution to green space deficiency in dense urban areas, the potential benefits of different BG initiatives have rarely been quantitatively pre-evaluated. Here, the concept and main features of BG and its costs and benefits are firstly depicted. Next, a conceptual framework is presented which combines ecosystem service (ESS) valuation, economic cost-benefit analysis, and spatial pattern analysis. The framework is used to perform ex ante valuation of the ESS value of BG in Xuhui District, Shanghai.

Outcomes:
The scenario comparison results show that it can spatially reflect a closer-to-reality value of ESS at the urban scale instead of a theoretical value at the site scale. The ultimate values of ESS (After economic and landscape adjustments) in the composite scenario is more than 21% higher than those in the full-eco scenario, whereas the initial values of ESS (before the adjustments) in the former was 14% lower than those in the latter. These results suggest that a considerable part of brownfield greening projects need to be implemented in the more populated and economically vibrant areas instead of solely in the ecological construction zone, thereby correspondingly providing more cultural and regulation services and forming a better urban green space network.

Conclusion:
The framework provides a simple, science-based, and feasible tool for making BG decisions from a systematic perspective in dense urban areas. It can help meet the need for applying ESS knowledge to BG-based green space planning and policy making in the context of urban sustainable development.
Fasting plastic: an intervention study to break habits of plastic consumption (Ayuno de plástico: una intervención para cambiar los hábitos de consumo de plásticos)
Authors: Heidbreder Lea Marie , Schmitt Manfred
Published: March 2020

Addressing the prevalent topic of plastic pollution, an intervention to break people’s consumption patterns was implemented. It was investigated if Lent could work as a ‘window of opportunity’ of habit change, expecting people to be open to try new behaviour in this period. An online survey was conducted before, during and after Lent. 140 persons in three different intervention groups, including an invitation to the plastic challenge (baseline), information about problems (group I) and information about action steps (group II) participated by the end. Mixed ANOVA revealed a reduction of plastic consumption during Lent ( d = 0.69). This effect was maintained even after Lent. Informational approaches showed no further effect. Path analysis revealed insights in antecedents of fasting behaviour and habit change. Intention, previous behaviour and moral norms were direct predictors of plastic reduction during Lent. In turn, people who reduced plastic consumption in this period continued it after Lent independent of other constructs. Implications of these results are discussed.
Drinking water quality from rural handpump-boreholes in Africa
Authors: Lapworth D J , MacDonald A M , Kebede S , Owor M , Chavula G , Fallas H , Wilson P , Ward J S T , Lark M , Okullo J , Mwathunga E , Banda S , Gwengweya G , Nedaw D , Jumbo S , Banks E , Cook P , Casey V
Published: March 2020

Groundwater provides a vital source of drinking water for rural communities in many parts of Africa, particularly in the dry season when there are few safe alternative sources. This paper summarises results from a study (n = 428) assessing dry season water quality, both microbiological and inorganic chemistry, in handpump equipped boreholes (HPBs) across the Ethiopia Highlands (n = 142), Malawi (n = 162) and Uganda (n = 124) using a stratified, randomised sampling design. This study seeks to examine general water quality by randomly sampling rural groundwater supplies across larger areas with different geology and climate. The majority, 72%, of HPBs surveyed provide good quality dry season drinking water as defined by WHO drinking water quality criteria. Within this overall picture, the most notable constraints were from thermotolerant coliforms (TTCs), which exceeded the WHO drinking water guideline of zero colony forming units (cfu/100 ml) in 21% of sites (range 0–626 cfu/100 ml). TTC contamination was found to have a significant and positive correlation with annual average rainfall (ρ = 0.2, p = 0.00003). Across all three countries, WHO health based chemical drinking water quality values were exceeded at 9% of sites and were found for manganese (4%), fluoride (2.6%) and nitrate (2.5%); arsenic concentrations were below the guideline value of 10 μg l−1 (range < 0.5–7 μg l−1). The high percentage of Mn exceedances (14% ± 5.2% >400 μg l−1) found in drinking water sources in Uganda challenges the decision by WHO not to formalise a health-based guideline for Mn. While the overall level of microbiological contamination from HPBs is low, results from this study strongly suggest that at a national and regional level, microbiological contamination rather than chemical contamination will provide a greater barrier to achieving targets set for improved drinking water quality under the UN-SDG 6. Efforts should be made to ensure that boreholes are properly sited and constructed effectively to reduce pathogen contamination.
Attribution of the record-breaking heat event over Northeast Asia in summer 2018: the role of circulation
Authors: Ren Liwen , Zhou Tianjun , Zhang Wenxia
Published: March 2020

In summer 2018, an extraordinary heat wave with record-breaking high temperatures hit Northeast Asia. However, the contribution of atmospheric circulation to this heat wave remains unknown. In this study, we quantify the contribution of circulation by using the flow analogue method. It is found that Northeast China, Korea and Japan were the most affected areas by the heat event, from daily to monthly timescales. The persistent high temperature was associated with an anticyclonic anomaly over Northeast Asia, related to the record-breaking northward shift of the western Pacific subtropical high (WPSH). The persistent anomalous anticyclone played a dominant role in this heat event, explaining half of the magnitude of the heat event. Both thermodynamical change and dynamical change in recent decades have increased the probability of occurrence of this kind of heat event over Northeast Asia. Specifically, the change in dynamical flow explains a fraction of less than 20% of the increases in probability of heat events. The contribution of thermodynamical changes to heat events generally increases with the rarity of the extreme event.
Reducing stranded assets through early action in the Indian power sector
Authors: Malik Aman , Bertram Christoph , Despres Jacques , Emmerling Johannes , Fujimori Shinichiro , Garg Amit , Kriegler Elmar , Luderer Gunnar , Mathur Ritu , Roelfsema Mark , Shekhar Swapnil , Vishwanathan Saritha , Vrontisi Zoi
Published: March 2020

Cost-effective achievement of the Paris Agreement’s long-term goals requires the unanimous phase-out of coal power generation by mid-century. However, continued investments in coal power plants will make this transition difficult. India is one of the major countries with significant under construction and planned increase in coal power capacity. To ascertain the likelihood and consequences of the continued expansion of coal power for India’s future mitigation options, we use harmonised scenario results from national and global models along with projections from various government reports. Both these approaches estimate that coal capacity is expected to increase until 2030, along with rapid developments in wind and solar power. However, coal capacity stranding of the order of 133–237 GW needs to occur after 2030 if India were to pursue an ambitious climate policy in line with a well-below 2 °C target. Earlier policy strengthening starting after 2020 can reduce stranded assets (14–159 GW) but brings with it political economy and renewable expansion challenges. We conclude that a policy limiting coal plants to those under construction combined with higher solar targets could be politically feasible, prevent significant stranded capacity, and allow higher mitigation ambition in the future.
Synthesis of ZnO nanoparticles by two different methods & comparison of their structural, antibacterial, photocatalytic and optical properties
Authors: Haque Md Jahidul , Bellah Md Masum , Hassan Md Rakibu , Rahman Suhanur
Published: March 2020

In this work, two different methods (sol-gel and biosynthesis) were adopted for the synthesis of zinc oxide (ZnO) nanoparticles. The leaf extract of Azadirachta Indica (Neem) was utilized in the biosynthesis scheme. Structural, antibacterial, photocatalytic and optical performances of the two variants were analyzed. Both variants demonstrated a wurtzite hexagonal structure. The biosynthesized variant (25.97 nm) exhibited smaller particles than that of the sol-gel variant (33.20 nm). The morphological analysis revealed that most of the particles of the sol-gel variant remained within the range of 15 nm to 68 nm while for the biosynthesized variant the range was 10–70 nm. The antibacterial assessment was redacted by using the agar well diffusion method in which the bacteria medium was Escherichia coli O157: H7. The zone of inhibition of bacterial growth was higher in the biosynthesized variant (14.5 mm). The photocatalytic performances of the nanoparticles were determined through the degradation of methylene blue dye in which the biosynthesized variant provided better performance. The electron spin resonance (EPR) analysis revealed that the free OH · radicals were the primary active species for this degradation phenomenon. The absorption band of the sol-gel and biosynthesized variants were 363 nm and 356 nm respectively. The optical band gap energy of the biosynthesized variant (3.25 eV) was slightly higher than that of the sol-gel variant (3.23 eV). Nevertheless, the improved antibacterial and photocatalytic responses of the biosynthesized variants were obtained due to the higher rate of stabilization mechanism of the nanoparticles by the organic chemicals (terpenoids) present in the Neem leaf extract.
Welcome to Nano Express
Authors: Di Bartolomeo Antonio
Published: March 2020

Science at the nanoscale is multidisciplinary and intersects communities extending across physics, materials science, engineering, chemistry, biology, medicine and environmental science as well as industry. Nano Express reflects this situation as a cross-disciplinary open access journal that builds upon IOP Publishing’s long-standing reputation of serving the whole nanoscience community.
Translation-invariant line bundles on linear algebraic groups
Authors: Rosengarten Zev
Published: March 2020

We study the Picard groups of connected linear algebraic groups and especially the subgroup of translation-invariant line bundles. We prove that this subgroup is finite over every global function field. We also utilize our study of these groups in order to construct various examples of pathological behavior for the cohomology of commutative linear algebraic groups over local and global function fields.
A high-order perturbation of envelopes (HOPE) method for scattering by periodic inhomogeneous media
Authors: Nicholls David
Published: March 2020

The interaction of linear waves with periodic structures arises in a broad range of scientific and engineering applications. For such problems it is often mandatory that numerical simulations be rapid, robust, and highly accurate. With such qualities in mind High-Order Spectral methods are often utilized, and in this paper we describe and test a perturbative method which fits into this class. Here we view the inhomogeneous (but laterally periodic) permittivity as a perturbation of a constant value and pursue (regular) perturbation theory. We demonstrate that not only does this lead to a fast and accurate numerical method, but also that the expansion of the field in this geometric parameter is valid for large deformations (up to topological obstruction). Finally, we show that, if the permittivity deformation is spatially analytic, then so is the field scattered by it.
Soluble tumour necrosis factor-alpha receptor improved the function, hypertrophy, and granular sparkling appearance of the left ventricular myocardium in systemic amyloid A amyloidosis: a case report
Authors: Miyagawa Sawa , Miyamoto Tadashi , Sato Yukihito
Published: March 2020

Background

About 7% of amyloid A (AA) amyloidosis cases are accompanied by heart disease. Although several studies have recently reported that specific biologicals improved renal function in AA amyloidosis, little evidence is available regarding heart disease in AA amyloidosis.

Case summary

A 57-year-old woman with rheumatoid arthritis presented with sudden worsening of renal function. Echocardiography revealed granular sparkling appearance in the ventricular septum and posterior wall (PW). Echocardiography indicated left ventricular (LV) diastolic dysfunction. Global longitudinal strain (GLS) exhibited an apical sparing pattern. Cardiac biopsy demonstrated amyloid A deposition on immunostaining. Soluble tumour necrosis factor-alpha receptor etanercept therapy was initiated. Four years later, echocardiography showed improved diastolic function, including E/A and E/e’, and decreased wall thickness in both the interventricular septum and PW of the left ventricle. Granular sparkling appearance had diminished. Moreover, the LV dysfunction improved on GLS. Five years later, the medication was gradually losing effect and the patient had worsening pain in the joints; moreover, articular destruction was observed on radiography. The patient was switched to abatacept therapy. Echocardiography showed recurrence of LV hypertrophy and electrocardiogram showed down-sloped ST depression in V4–6 leads.

Discussion

This case indicates that etanercept can be effective for heart disease in AA amyloidosis. Of particular, interest is the improvement of granular sparkling appearance in addition to cardiac function improvement noted in this case.
Secession with Natural Resources
Authors: Dhillon Amrita , Krishnan Pramila , Patnam Manasa , Perroni Carlo
Published: March 2020

We look at the formation of new Indian states in 2001 to uncover the effects of political secession on the comparative economic performance of natural resource rich and natural resource poor areas. Resource rich constituencies fared comparatively worse within new states that inherited a relatively larger proportion of natural resources. We argue that these patterns reflect how political reorganisation affected the quality of state governance of natural resources. We describe a model of collusion between state politicians and resource rent recipients that can account for the relationships we see in the data between natural resource abundance and post-break-up local outcomes.
Monopolizing War: Codifying the Laws of War to Reassert Governmental Authority, 1856–1874
Authors: Benvenisti Eyal , Lustig Doreen
Published: March 2020

In this article, we challenge the canonical narrative about civil society’s efforts to discipline warfare during the mid-19th century – a narrative of progressive evolution of Enlightenment-inspired laws of war, later to be termed international humanitarian law. Conversely, our historical account shows how the debate over participation in international law-making and the content of the law reflected social and political tensions within and between European states. While the multifaceted influence of civil society was an important catalyst for the inter-governmental codification of the laws of war, the content of that codification did not simply reflect humanitarian sensibilities. Rather, as civil society posed a threat to the governmental monopoly over the regulation of war, the turn to inter-state codification of IHL also assisted governments in securing their authority as the sole regulators in the international terrain. We argue that, in codifying the laws of war, the main concern of key European governments was not to protect civilians from combatants’ fire, but rather to protect combatants from civilians eager to take up arms to defend their nation – even against their own governments’ wishes. We further argue that the concern with placing ‘a gun on the shoulder of every socialist’ extended far beyond the battlefield. Monarchs and emperors turned to international law to put the dreaded nationalist and revolutionary genies back in the bottle. These concerns were brought to the fore most forcefully in the Franco-Prussian War of 1870–1871 and the subsequent short-lived, but violent, rise of the Paris Commune. These events formed the backdrop to the Brussels Declaration of 1874, the first comprehensive text on the laws of war. This Declaration exposed civilians to war’s harms and supported the growing capitalist economy by ensuring that market interests would be protected from the scourge of war and the consequences of defeat.
The EU’s Most Influential Economic Policy-maker: Mario Draghi at the European Central Bank
Authors: Waibel Michael
Published: March 2020

This article assesses the legacy of Mario Draghi as president of the European Central Bank (ECB) from 2011 to 2019, with particular reference to the Greek’s sovereign debt crisis. Most macro-economic indicators improved over the course of Draghi’s tenure at the ECB, including inflation, budget deficits, yield spreads among euro-area borrowers and unemployment. Draghi played a decisive role in turning the tide on the crisis of confidence that afflicted the euro area and threatened the survival of Europe’s single currency in the wake of Greece’s sovereign debt crisis. Yet the ECB’s unconventional policies prompted sustained controversy and contributed to a low level of trust in the central bank among people in the euro-area member states. The focus of controversy has been on possible asset-price bubbles and ‘hidden’ transfers between euro-area member states. When and how to normalize its policies is a major challenge for the ECB, as it is for other major central banks that adapted similar policies in response to the global financial crisis.
Introduction of covariance components in slip inversion of geodetic data following a non-uniform spatial distribution and application to slip deficit rate estimation in the Nankai Trough subduction zone
Authors: Agata Ryoichiro
Published: March 2020

Inappropriate mathematical treatment of prediction errors associated with inaccurate forward modelling in an inversion scheme may result in significant unnatural short-wavelength components in the estimated slip distribution, which is a typical consequence of overfitting data. When geodetic data in observation stations following a non-uniform spatial distribution are used in a geodetic slip inversion, the spatial non-uniformity of the observation can possibly influence the distribution pattern of the short-wavelength components significantly, which may be confused with slip patterns that are geophysically meaningful. Such situations often occur when land and seafloor geodetic data are used in combination in slip inversions. To avoid overfitting, this study proposes a method that incorporates covariance components in the covariance matrix of the misfit vector, which originate from prediction errors. Because the proposed method retains the linearity of the inversion problem, widely known approaches that introduce prior constraints to a linear inversion problem are easily combined with the proposed method. This study demonstrates a combination of the newly introduced covariance components with a prior constraint on the smoothness of slip distribution, constructing a Bayesian model with unknown hyperparameters, which are objectively determined by minimizing Akaike’s Bayesian information criterion. In the synthetic tests, the proposed method estimated slip deficit rate (SDR) distributions that are closer to the true one, avoiding overfitting the geodetic data with spatial non-uniformity. By contrast, a conventional approach, which does not introduce covariance components, estimates unnaturally rough SDR distributions using the same synthetic data. The proposed method was applied to the estimation of SDR in the Nankai Trough subduction zone, using geodetic data of displacement rates provided by land GNSS stations and seafloor GNSS-Acoustic stations. This method estimates a reasonably smooth distribution of SDR, avoiding overfitting. The spatial distribution of residuals of the displacement rates suggests that the proposed method avoids overfitting some portions of the observed displacement rates that the forward model set for the analyses could not fundamentally explain.
Honey Bee (Hymenoptera: Apidea) Pollen Forage in a Highly Cultivated Agroecosystem: Limited Diet Diversity and Its Relationship to Virus Resistance
Authors: Zhang Ge , St. Clair Ashley L , Dolezal Adam , Toth Amy L , O’Neal Matthew
Published: March 2020

Intensified agriculture reduces natural and seminatural habitats and plant diversity, reducing forage available to honey bees (Apis mellifera L. [Hymenoptera: Apidea]). In agricultural landscapes of Iowa, United States, we studied the impact of extrinsic agricultural intensification on the availability of pollen for honey bees by placing colonies next to soybean fields surrounded by either a low or high level of cultivation. The abundance and diversity of pollen returned to a colony were estimated by placing pollen traps on bee colonies during the summer and fall of 2015 and 2016. We observed no difference in abundance and diversity of pollen collected by colonies in either landscape, but abundance varied over time with significantly less collected in September. We explored if the most commonly collected pollen from these landscapes had the capacity to support honey bee immune health by testing if diets consisting of these pollens improved bee resistance to a viral infection. Compared to bees denied pollen, a mixture of pollen from the two most common plant taxa (Trifolium spp. L. [Fabales: Fabaceae] and Chimaechrista fasciculata (Michx.) Greene [Fabales: Fabaceae]) significantly reduced honey bee mortality induced by viral infection. These data suggest that a community of a few common plants was favored by honey bees, and when available, could be valuable for reducing mortality from a viral infection. Our data suggest a late season shortage of pollen may be ameliorated by additions of fall flowering plants, like goldenrod (Solidago spp. L. [Asterales: Asteraceae]) and sunflower (Helianthus, Heliopsis, and Silphium spp. [Asterales: Asteraceae]), as options for enhancing pollen availability and quality for honey bees in agricultural landscapes.
Extensive mediastinal thymolipoma mimicking pulmonary edema
Authors: Yusuf Mohamud Mohamed Farah , Ahmed Mohamed Abdi , Ali Ibrahim Hussein
Published: March 2020

Thymolipoma is a rare benign slow-growing encapsulated tumor of anterior mediastinum that accounts for 2–9% of all thymic neoplasms. About 30–50% of them are asymptomatic and found incidentally. Less than 200 cases have been published in the world literature so far. Here we report a case of thymolipoma of an adult female presented with progressive dyspnea, chest tightness and non-productive chough for 2-month duration. All blood investigations were normal. Radiological examinations suggested the presence of fat and soft tissue within the tumor without invading the neighboring structures. We concluded that the only curative treatment of thymolipoma is surgical excision. Unfortunately, the patient did not give consent despite telling her the outcomes if we do not do the surgical procedure, and a week later she passed away due to respiratory distress secondary to the mass effect of the tumor.
Aviation-Modeled Investigation of Significant Obstetric Events
Authors: Powell-Dunford Nicole , Deuster Patricia , McPherson Mark , Gaydos Steven J
Published: March 2020

Introduction

In this research, the authors attempted to ascertain whether or not the Root Cause Analysis Event Support and Engagement Team (RESET) investigates the use of U.S. Army aviation-based techniques by staff members or organizations in which serious obstetrical events have occurred. Root cause analysis (RCA), originating in the manufacturing and engineering sectors, attempts to elucidate an underlying cause of a problem. Most recently, this process has been applied to the investigation of medical error. RESET was established in order to perform centralized investigation of significant medical error within U.S. Army medical and dental treatment facilities based on request from a hospital commander or general officer. Significant obstetric events are high profile, discussed in multiple safety forums, and an area of close RESET focus. Yet it is unclear if RESET investigates the use of aviation-based techniques by staff and/or organizations involved in serious obstetrical events. Therefore the present survey study was conducted.

Materials and Methods

A structured, anonymous, voluntary survey was fielded to RESET staff in order to assess whether or not the RESET investigates the use of aviation-based techniques by staff members or organizations in which serious obstetrical events have occurred.

Results

Five of six members of this small team completed the survey. Prebriefs, debriefs, and checklist use were consistently investigated. The employment of a sterile cockpit, first-name introductions, annual check ride, and emergency procedure rehearsal were infrequently investigated.

Conclusion

Obstetric RESET investigations inconsistently ascertain whether or not some of the aviation-based techniques are utilized by staff members or organizations in which serious obstetrical events have occurred. Standardization of investigative procedures and education directed at under-investigated practices may optimize medical investigation using proven tenets of an aviation-based approach.
Verification of Ocular Trauma Score for Intraocular Foreign Bodies in Lethal-Weapon-Related Ocular Injuries
Authors: Guven Soner
Published: March 2020

Introduction

The ocular trauma score (OTS) is a widely used predictive tool in determining the visual prognosis of ocular injuries. Intraocular-foreign-body (IOFB)-type injuries comprise the leading type of open-globe injuries (OGI) in ocular combat injuries. However, there are scarce reports evaluating the efficacy of OTS in IOFB-type injuries. Only one study is available that explored the validity of OTS in combat-related IOFB injuries with a limited number of eyes. The aim of this study is to confirm the predictive value of OTS in lethal-weapon (LW)-related OGI with IOFB.

Material and Methods

The charts of 488 patients with IOFB-type-eye injuries between January 1998 and January 2018 were analyzed. Only the LW-related ocular injuries were included. Baseline details (patient demographics, surgeries, OTS categories, and visual acuity [VA]) were recorded. To test the validity of OTS, Fischer exact test was used to compare the likelihood of the final VAs for every OTS subgroups between OTS study group and this study.

Results

The complete data of 206 eyes of 142 patients including two civilians were analyzed in the study. No subjects had ocular protection at the time of the injury. OTS study and this current study did not show an exact validation in first three OTS categories in various final VA subgroups (no light perception (NLP) subgroup (P: 0.001), light perception/hand movements subgroup (P: 0.033), 20/200 to 20/50 subgroup (P: 0.047) in OTS category 1; NLP subgroup (P: 0.000), 20/200 to 20/50 subgroup (P: 0.036), 20/40 subgroup (P: 0.018) in OTS 2; and 20/200 to 20/50 subgroup (P: 0.01), 20/40 subgroup (P: 0.003) in OTS 3, respectively). The above results indicate that in first three OTS categories, OTS study was not useful in visual prognosis prediction in the mentioned VA subgroups. The results predicted the final VA only in OTS categories 4 and 5 in which all P values were greater than 0.05.

Conclusions

Visual outcome of this type of ocular injury may be unpredictable due to more frequent discouraging results. OTS failed to predict visual outcome in first three OTS categories in this study. Therefore, OTS appears to be verified only in better (OTS categories 4 and 5) categories.
The role of galaxies and AGN in reionizing the IGM – III. IGM–galaxy cross-correlations at z ∼ 6 from eight quasar fields with DEIMOS and MUSE
Authors: Meyer Romain A , Kakiichi Koki , Bosman Sarah E I , Ellis Richard S , Laporte Nicolas , Robertson Brant E , Ryan-Weber Emma V , Mawatari Ken , Zitrin Adi
Published: March 2020

We present improved results of the measurement of the correlation between galaxies and the intergalactic medium transmission at the end of reionization. We have gathered a sample of 13 spectroscopically confirmed Lyman-break galaxies (LBGs) and 21 Lyman-α emitters (LAEs) at angular separations 20 arcsec ≲ θ ≲ 10 arcmin (∼0.1–4 pMpc at z ∼ 6) from the sightlines to eight background z ≳ 6 quasars. We report for the first time the detection of an excess of Lyman-α transmission spikes at ∼10–60 cMpc from LAEs (3.2σ) and LBGs (1.9σ). We interpret the data with an improved model of the galaxy–Lyman-α transmission and two-point cross-correlations, which includes the enhanced photoionization due to clustered faint sources, enhanced gas densities around the central bright objects and spatial variations of the mean free path. The observed LAE(LBG)–Lyman-α transmission spike two-point cross-correlation function (2PCCF) constrains the luminosity-averaged escape fraction of all galaxies contributing to reionization to $\langle f_{\rm esc} \rangle _{M_{\rm UV}\lt -12} = 0.14_{-0.05}^{+0.28}\, (0.23_{-0.12}^{+0.46})$. We investigate if the 2PCCF measurement can determine whether bright or faint galaxies are the dominant contributors to reionization. Our results show that a contribution from faint galaxies ($M_{\rm UV} \gt -20 \, (2\sigma)$) is necessary to reproduce the observed 2PCCF and that reionization might be driven by different sub-populations around LBGs and LAEs at z ∼ 6.
The White Dwarf Binary Pathways Survey −III. Contamination from hierarchical triples containing a white dwarf
Authors: Lagos F , Schreiber M R , Parsons S G , Zurlo A , Mesa D , Gänsicke B T , Brahm R , Caceres C , Canovas H , Hernandez M-S , Jordan A , Koester D , Schmidtobreick L , Tappert C , Zorotovic M
Published: March 2020

The White Dwarf Binary Pathways Survey aims at increasing the number of known detached A, F, G, and K main-sequence stars in close orbits with white dwarf companions (WD+AFGK binaries) to refine our understanding about compact binary evolution and the nature of Supernova Ia progenitors. These close WD+AFGK binary stars are expected to form through common envelope evolution, in which tidal forces tend to circularize the orbit. However, some of the identified WD+AFGK binary candidates show eccentric orbits, indicating that these systems are either formed through a different mechanism or perhaps they are not close WD+AFGK binaries. We observed one of these eccentric WD+AFGK binaries with SPHERE and find that the system TYC 7218-934-1 is in fact a triple system where the WD is a distant companion. The inner binary likely consists of the G-type star plus an unseen low-mass companion in an eccentric orbit. Based on this finding, we estimate the fraction of triple systems that could contaminate the WD+AFGK sample. We find that less than 15 per cent of our targets with orbital periods shorter than 100 d might be hierarchical triples.
Bevacizumab-based treatment as salvage therapy in patients with recurrent symptomatic brain metastases
Authors: Berghoff Anna Sophie , Breckwoldt Michael Oliver , Riedemann Lars , Karimian-Jazi Kianush , Loew Sarah , Schlieter Franziska , Furtner Julia , Cinci Marc , Thomas Michael , Strowitzki Moritz J , Marmé Frederik , Michel Laura L , Schmidt Thomas , Jäger Dirk , Bendszus Martin , Preusser Matthias , Wick Wolfgang , Winkler Frank
Published: March 2020

Background

Salvage treatment for recurrent brain metastases (BM) of solid cancers is challenging due to the high symptomatic burden and the limited local treatment options.

Methods

Patients with recurrent BM with no option for further local therapies were retrospectively identified from BM databases. Bevacizumab-based treatment was initiated as a salvage treatment. Radiological imaging before and after bevacizumab-based treatment was reevaluated for treatment response using the Response Assessment in Neuro-Oncology (RANO) BM criteria.

Results

Twenty-two patients (36.4% male) with recurrent BM from breast cancer (40.9%), colorectal cancer (31.8%), or lung cancer (27.3%) were identified. Previous BM-directed therapies were radiosurgery in 16/22 (72.7%) patients, whole-brain radiotherapy in 8/22 (36.4%), and neurosurgical resection in 11/22 (50.0%). Time since BM diagnosis to initiation of bevacizumab treatment was 16.5 months. Of 22 patients 14 (63.6%) received concurrent systemic therapies. Neurological symptom improvement could be achieved in 14/22 (63.6%) and stabilization in 6/22 (27.3%) patients, resulting in a clinical benefit in 20/22 (90.9%) patients. Steroids could be reduced or stopped in 15/22 (68.2%) patients. Rate of improvement on T1-weighted imaging was 15/19 (78.9%; median reduction: −26.0% ± 32.9) and 19/20 (95%; median reduction: −36.2% ± 22.2) on T2-weighted FLAIR imaging. According to RANO-BM best response was partial response in 7/19 (36.8%), stable disease in 9/19 (47.3%), and progressive disease in 3/19 (15.7%) patients. Median CNS-specific progression-free survival was 8 months and median overall survival after initiation of bevacizumab treatment was 17 months.

Conclusions

Bevacizumab-based treatment had clinically relevant intracranial activity in the vast majority of patients suffering from recurrent, symptomatic BM. The data supports a prospective clinical trial of bevacizumab as a salvage treatment in BM.
Prevalence and Discordance of the “Startle Response” with True Discogenic Pain According to Spine Intervention Society Guidelines for Provocation Discography: A Cohort Study
Authors: DeFrancesch Fred , Sperry Beau P , Aprill Charles N , Choe Douglas , McCormick Zachary L
Published: March 2020

Summary of Background Data

The literature on cervical provocation discography (C-PD) is sparse. A “Startle Response” during C-PD is a known phenomenon that might be mistaken as an indicator of discogenic pain at the provoked disc level, but this has not been quantitatively described.

Objectives

To determine the incidence of the Startle Response and its concordance/discordance with true-positive C-PD in patients referred for surgical planning or evaluation after ruling out other axial pain generators.

Methods

Retrospective cohort study of consecutive patients who received C-PD at an outpatient spine center. The primary outcome was the rate of discordance of the Startle Response with true-positive C-PD according to the operational criteria of the Spine Intervention Society (SIS) guidelines.

Results

One hundred five discs were provoked in 36 individuals (19 female, mean age [SD] = 45.7 [10.9] years). C-PD was performed at a median of three levels (range = 1–5) with C4/5 (N = 30), C5/6 (N = 30), and C6/7 (N = 31) the most commonly evaluated. Twenty-six of 36 patients reported responses consistent with true-positive C-PD. A Startle Response was observed in 14 patients (39%, 95% confidence interval [CI] = 23–57%), and 22 of 105 (21%, 95% CI = 14–30%) provoked discs. Of the 14 patients who exhibited a Startle Response, four had negative C-PD results (29%, 95% CI = 8–58%). As assessed per disc, C-PD results were positive in 12 of the 22 (55%, 95% CI = 32–76%) provoked discs that generated a Startle Response.

Conclusions

The present data demonstrate high discordance, 45% (95% CI = 24–68%), between the Startle Response and true-positive C-PD. Clinicians should be aware of this phenomenon and take care to distinguish it from a true-positive response during C-PD, as defined by the SIS guidelines. Misinterpretation of the Startle Response as a positive C-PD result may lead to inappropriate future care decisions in a substantial proportion of patients.
Identification of Reproducible BCL11A Alterations in Schizophrenia Through Individual-Level Prediction of Coexpression
Authors: Chen Junfang , Cao Han , Kaufmann Tobias , Westlye Lars T , Tost Heike , Meyer-Lindenberg Andreas , Schwarz Emanuel
Published: March 2020

Previous studies have provided evidence for an alteration of genetic coexpression in schizophrenia (SCZ). However, such analyses have thus far lacked biological specificity for individual genes, which may be critical for identifying illness-relevant effects. Therefore, we applied machine learning to identify gene-specific coexpression differences at the individual subject level and compared these between individuals with SCZ, bipolar disorder, major depressive disorder (MDD), autism spectrum disorder (ASD), and healthy controls. Utilizing transcriptome-wide gene expression data from 21 independent datasets, comprising a total of 9509 participants, we identified a reproducible decrease of BCL11A coexpression across 4 SCZ datasets that showed diagnostic specificity for SCZ when compared with ASD and MDD. We further demonstrate that individual-level coexpression differences can be combined in multivariate coexpression scores that show reproducible illness classification across independent datasets in SCZ and ASD. This study demonstrates that machine learning can capture gene-specific coexpression differences at the individual subject level for SCZ and identify novel biomarker candidates.
Artificial selection versus natural selection: Which causes the Matthew effect of science funding allocation in China?
Authors: Zhang Gupeng , Xiong Libin , Wang Xiao , Dong Jianing , Duan Hongbo
Published: March 2020

To investigate either artificial or natural selection leads to the Matthew effect in the science funding allocation and its consequences, this study retrieves 274,732 publications by Chinese scientists from the Web of Science and examines how the disparity of science funding determines scientists’ research performance. We employ the Negative Binomial Model and other models to regress the publication’s citation times, which measures the research performance, on the number of funding grants and their amounts of currency that the publication receives, which measures the disparity of science funding. The empirical results suggest an inverted U-shaped relationship. However, the optimum number of funding grants far exceeds the actual number that most publications receive, implying that increasing the funding for academic research positively impacts scientists’ research performance. The natural disparity thus plays a major role in distributing the science funding. Additionally, China’s publication-based academic assessment system may be another main cause.
Identifying Races ofFusarium oxysporumf. sp.niveumin South Carolina Recovered From Watermelon Seedlings, Plants, and Field Soil
Authors: Keinath Anthony P. , DuBose Virginia B. , Katawczik Melanie M. , Wechter W. Patrick
Published: March 2020

Fusarium wilt of watermelon (Citrullus lanatus), caused by the soilborne fungus Fusarium oxysporum f. sp. niveum, is the most serious disease of watermelon in South Carolina and other southeastern U.S. states. Isolates of F. oxysporum collected from field-grown plants, greenhouse-grown seedlings, and field soil between 1999 and 2018 were inoculated onto three differential watermelon cultivars to identify races. Of 197 isolates obtained from plants, 12% were nonpathogenic, 2% were race 0, 23% were race 1, and 63% were race 2. One collection of isolates from greenhouse seedlings was exclusively race 1 and the other was exclusively race 2. Seventeen of 81 soil isolates were pathogenic: five were race 1 and 12 were race 2. Reactions of C. amarus PI 296341-FR, Carolina Strongback, and SP-6, cultigens with resistance to race 2, did not differ significantly among five highly virulent race 2 isolates and a standard race 2 isolate, indicating a lack of a race 3 phenotype. Forma specialis-specific primers matched phenotypic race identification for 74% of the isolates. Race-specific primers based on a secreted-in-xylem elicitor present in race 0 and 1 isolates matched phenotypic race identification for 66% of the isolates. Because a majority of the F. oxysporum f. sp. niveum isolates from South Carolina were race 2, integrated management practices should be used until commercial cultivars with resistance to race 2 are available.
An Evaluation of a Continuing Education Workshop for Audiologists on the Assessment and Management of Tinnitus
Authors: Searchfield Grant D. , Fok Christine , Donaldson Tom , Durai Mithila , Kleinstäuber Maria , Linford Tania , Maslin Maslin
Published: March 2020

Introduction:

Tinnitus assessment and management is an important component of audiology. The benefits of continuing education (CE) workshops in the field of tinnitus have not been published. This study evaluated the outcomes of a workshop centered around a Sound Therapy and Aural Rehabilitation for Tinnitus (START) framework. Our hypotheses were that a CE workshop would (1) be useful, (2) improve clinician's knowledge and willingness to undertake tinnitus practice, and (3) result in learners using knowledge gained in their practice.

Methods:

Twenty-five participants attending a 3-day tinnitus workshop were invited to complete an evaluation immediately and 3 months after the workshop’s completion. The workshop consisted of seminars and practical sessions. The pedagogical approaches employed were experiential (theory building, reflection, and testing) and community of practice (shared experiences).

Results:

Participants reported on a 5-point Likert scale (1 = not useful—5 = excellent) a high level of satisfaction both immediately after the workshop (ratings of usefulness: mean, 4.8; SD, 0.4; willingness to practice: 4.6; SD. 0.6; ability to manage: 4.6; SD, 0.5; all “excellent” ratings) and 3 months later (ratings of usefulness: mean, 4.2; SD, 0.9, “very useful;” willingness to practice: 4.6; SD, 0.6, “excellent;” ability to manage: 4.1; SD. 0.5, “very useful”). Open-ended questions indicated participants made changes in their practice that reflected material provided in the CE.

Conclusion:

The workshop was successful in improving knowledge and confidence of audiologists in undertaking tinnitus assessment and management, but the need for ongoing support and supervision was a common theme.
Association Between Vaccine Exemption Policy Change in California and Adverse Event Reporting
Authors: Hause Anne M. , Hesse Elisabeth M. , Ng Carmen , Marquez Paige , McNeil Michael M. , Omer Saad B.
Published: March 2020

Background:

California Senate Bill 277 (SB277) eliminated non-medical immunization exemptions. Since its introduction on February 19, 2015, the rate of medical exemptions in the state has increased. Filing a report to Vaccine Adverse Event Reporting System (VAERS) may be perceived as helpful in applying for a medical exemption. Our objective was to describe trends in reporting to VAERS from California coincident with introduction of SB277.

Methods:

This was a retrospective study of Californian children <18 years for whom a VAERS report was submitted between June 1, 2011 and July 31, 2018. VAERS is a national, passive, vaccine safety surveillance program co-managed by Centers for Disease Control and Prevention and FDA. The main outcomes were the proportion of VAERS reports submitted by parents (vs. other reporter types), time from immunization to VAERS report (reporting time), and adverse event type. We also performed spatial analysis, mapping reports pre- and post-mandate by county.

Results:

We identified 6703 VAERS reports from California during the study period. The proportion of reports received from parents increased after implementation of SB277, from 14% to 23%. The median reporting time by parents increased from 9 days in 2013–2014 to 31 days in 2016–2017. After the introduction of SB277, we observed an increase in reports describing behavioral and developmental symptoms among reports submitted >6 months after immunization.

Conclusions:

These recent changes in reporting patterns coincident with the introduction of SB277 may indicate that more parents are using VAERS to assist in applying for a medical exemption for their child.
High-dose Dexamethasone in a Child With Enteric Encephalopathy Caused by Salmonella enterica serovar Typhi
Authors: Laps Alexandra M. , Foster Cortney B. , Laurens Matthew B.
Published: March 2020

Increased antimicrobial resistance to Salmonella species threatens successful treatment of typhoid and other infectious diseases. Consequently, rare complications arising from incompletely treated typhoid could increase in frequency. We describe a case of enteric encephalopathy caused by Salmonella enterica serovar Typhi and the utility of adjunct treatment with corticosteroids.