bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengelolaan Program Pelatihan Kursus Komputer Microsoft Office di Lembaga Kursus GOLEVAT Kota Semarang
Authors: Kusuma Wardani Bhakti
Published: June 2023

Kursus dan pelatihan diperlukan dengan tujuan peningkatan skill komptenesi seorang individu maupun kelompok masyarakat dalam pendidikan non formal. Salah satu kemampuan yang dibutuhkan pada era sekarang ialah kemampuan skill komputer dengan program Microsoft Office. Lembaga GOLEVAT sebagai wadah penyelenggaraan peningkatan kemampuan kompetensi masyarakat yang berfokus pada bidang teknologi digital komputer. Penyelenggaraan dari suatu program memerlukan suatu pengelolaan yang terstruktur dan terencana untuk mencapai tujuan yang telah ditetapkan. penelitian ini bertujuan untuk mendeskripsikan pengelolaan program pelatihan kursus komputer Microsoft Office di lembaga kursus GOLEVAT Kota Semarang yang meliputi perencanaan, pelaksanaan, dan evaluasi serta mendeskripsikan faktor-faktor pendukung dan penghambat dari program.

Desain yang digunakan pada penelitian ini adalah menggunakan jenis penelitian kualitatif. Informan penelitian meliputi lima orang yang terdiri atas satu orang Pendiri, dua orang instruktur pengajar, dan dua orang peserta program. Pendiri disini merupakan informan utama dalam penelitian ini dan informan lainnya merupakan informan pendukung. Teknik keabsahan data yang digunakan dalam penelitian ini adalah triangulasi sumber dan triangulasi teknik, triangulasi ini dimulai dari menganalisis data menggunakan metode pengumpulan data, reduksi, penyajian dan penarikan kesimpulan.

Hasil penelitian menunjukkan bahwa dalam pengelolaan program pelatihan kursus komputer Microsoft Office meliputi tiga fungsi pokok pengelolaan yaitu perencanaan yang meliputi perumusan tujuan latar belakang, penetapan koordinasi pengajar, penetapan sasaran lokasi dan waktu yang berkaitan dengan biaya program, penggunaan modul materi yang berstandar Microsoft, pemilihan media, penentuan metode penyampaian, persiapan fasilitas sarana dan prasarana. Pelaksanaan meliputi kegiatan penggunaan media, modul, dan metode yang sudah direncanakan, menggerakkan peserta untuk bisa mengikuti kursus. Evaluasi program melalui soal latihan untuk mendapat sertifikat kompetensi. Evaluasi pengajar, modul, dan fasilitas media melalui link google form yang diisi langsung oleh peserta setelah program selesai yang digunakan seagai acuan Pimpinan untuk melakukan evaluasi dan perbaikan lembaga dan program.

Faktor pendukung program kursus pelatihan komputer Microsoft Office ialah minat peserta, pengajar yang berkompeten, media fasilitas yang mendukung. Faktor penghambat dari peserta adalah lupa akan rumus, untuk pengajar ialah naiknya tarif bahan bakar kendaraan. Saran yang bisa diberikan oleh peneliti ialah sebaiknya ada perekrutan pengajar yang resmi dan evaluasi dilakukan secara terstruktur dan terjadwal, kemudian padamateri untuk selalu update sesuai dengan perkembangan teknologi yang semakin maju.
An Analysis of the Gross Domestic Product of Municipalities: A Spatial Glance into the State of Paraná-Brazil
Authors: Cima Elizabeth Giron , da Rocha-Junior Weimar Freire , Uribe-Opazo Miguel Angel , Henrique Gustavo
Published: June 2023

The vast relevance of applications of spatial regression models has recently captured the interest of Economics and Agriculture, in the sense of better understanding the spatial behavior of the region under study, in the different forms of approaches. It is interesting to understand why some regions show greater variability than others, and why some forms of regional development are better explained. It is up to the researcher to understand, explore, and organize a series of observations, so that it is possible to make predictions, diagnoses, and recommendations to public policy managers and regional development agents. The municipalities’ Gross Domestic Product (Gdp) has driven studies involving spatial information. The objective of this study was to analyze the Gdp of the municipalities in Paraná-Brazil, in 2018, regarding soybean yield, corn yield, pig production, and the tax on the circulation of goods, through different approaches of spatial regression models. SAR and CAR models are global models, while the GWR model is considered a local one. Three spatial analysis models were used to perform this study: Spatial Autoregressive (SAR), Conditional Autoregressive (CAR), and Geographically Weighted Regression (GWR). The results were compared using the Akaike Information Criterion (AIC), Bayesian Information Criterion (BIC), Cross-Validation Criterion (CVC), and the descriptive graphic of residual diagnoses-Worm Plot. The best result obtained was for the GWR model, which best explained the GDP of the state of Paraná-Brazil in terms of its covariates.
Análisis empírico de los determinantes del comportamiento de consumo de hojas de coca en Bolivia periodo 2006-2021
Authors: Gutierrez Miranda Juan Marcelo
Published: June 2023

Este estudio permitió consolidar el conocimiento sobre los determinantes del consumo de hojas de coca en Bolivia. Estimando modelos pooled condicionales y aplicando técnicas de Machine Learning utilizamos las Encuestas de Hogares disponibles en el INE de Bolivia. Existen dos poblaciones en riesgo de convertirse en un problema de bienestar estructural de largo plazo, las naciones y pueblos originarios campesinos, y aquellos que están en extrema pobreza. Aparece el efecto compensatorio sustituyendo bienes de la canasta básica por hojas de coca y desaparece a mayor grado educativo e ingreso. El fumar y beber alcohol se comportan como bienes complementarios.
EXPLORING THE RELATIONSHIP BETWEEN YARN TYPE AND PACKING DENSITY: A STUDY OF SINGLE-PLY, TWO-PLY, AND SIRO-SPUN YARNS
Authors: Demir Murat
Published: June 2023

Studying the fiber positioning in the yarn structure is the essential point to understand the different characteristics of yarns that counted as alternatives to each other. This study explores the packing densities of single-ply, two-ply and Siro-spun spun yarns that have been stated as the alternative yarn types considering the production method or yarn structure. In the study, Modal, Tencel, polyethylene teraphtalete, and cotton fibers represent micro, regenerated, synthetic, and natural fibers were used for the production of the 29.50 Tex yarns. Cross-sectional views of the yarns were acquired according to the hard sectioning method, and the packing densities of yarns were calculated with image processing tools. Yarn packing densities were calculated as the ratio of total fiber area within the yarn cross-section to yarn cross-section. Results showed that single ply ring-spun and siro-spun yarns are in a more circular shape and have greater packing densities values than two-ply yarns. Besides, yarns produced from cotton fibers have the least packing density values in each spinning technology. Similar packing density values were obtained for micro Modal, Tencel, and PET single-ply and siro-spun yarns. Packing density values were also compared with USTER diameter and density values and significant relations between those values were found.
Construction and validation of a novel IGFBP3-related signature to predict prognosis and therapeutic decision making for Hepatocellular Carcinoma
Authors: Chen Jianlin , Zhuang Wanzhen , Xia Yu , Yin Xiaoqing , Tu Mingshu , Zhang Yi , Zhang Liangming , Huang Hengbin , Zhang Songgao , You Lisheng , Huang Yi
Published: June 2023

Background

IGFBP3 plays a pivotal role in carcinogenesis by being anomalously expressed in some malignancies. However, the clinical value of IGFBP3 and the role of IGFBP3-related signature in HCC remain unclear.

Methods

Multiple bioinformatics methods were used to determine the expression and diagnostic values of IGFBP3. The expression level of IGFBP3 was validated by RT-qPCR and IHC. A IGFBP3-related risk score (IGRS) was built via correlation analysis and LASSO Cox regression analysis. Further analyses, including functional enrichment, immune status of risk groups were analyzed, and the role of IGRS in guiding clinical treatment was also evaluated.

Results

IGFBP3 expression was significantly downregulated in HCC. IGFBP3 expression correlated with multiple clinicopathological characteristics and demonstrated a powerful diagnostic capability for HCC. In addition, a novel IGRS signature was developed in TCGA, which exhibited good performance for prognosis prediction and its role was further validated in GSE14520. In TCGA and GSE14520, Cox analysis also confirmed that the IGRS could serve as an independent prognostic factor for HCC. Moreover, a nomogram with good accuracy for predicting the survival of HCC was further formulated. Additionally, enrichment analysis showed that the high-IGRS group was enriched in cancer-related pathways and immune-related pathways. Additionally, patients with high IGRS exhibited an immunosuppressive phenotype. Therefore, patients with low IGRS scores may benefit from immunotherapy.

Conclusions

IGFBP3 can act as a new diagnostic factor for HCC. IGRS signature represents a valuable predictive tool in the prognosis prediction and therapeutic decision making for Hepatocellular Carcinoma.
Electrochemical biosensors in healthcare services: bibliometric analysis and recent developments
Authors: Yunus Ghazala , Singh Rachana , Raveendran Sindhu , Kuddus Mohammed
Published: June 2023

Biosensors are nowadays being used in various fields including disease diagnosis and clinical analysis. The ability to detect biomolecules associated with disease is vital not only for accurate diagnosis of disease but also for drug discovery and development. Among the different types of biosensors, electrochemical biosensor is most widely used in clinical and health care services especially in multiplex assays due to its high susceptibility, low cost and small in size. This article includes comprehensive review of biosensors in medical field with special emphasis on electrochemical biosensors for multiplex assays and in healthcare services. Also, the publications on electrochemical biosensors are increasing rapidly; therefore, it is crucial to be aware of any latest developments or trends in this field of research. We used bibliometric analyses to summarize the progress of this research area. The study includes global publication counts on electrochemical biosensors for healthcare along with various bibliometric data analyses by VOSviewer software. The study also recognizes the top authors and journals in the related area, and determines proposal for monitoring research.
copLAB gene prevalence and diversity among Trinidadian Xanthomonas spp. black-rot lesion isolates with variable copper resistance profiles
Authors: Ramnarine Stephen DB Jr , Jayaraman Jayaraj , Ramsubhag Adesh
Published: June 2023

Background

There has been limited exploration of copLAB genotypes and associated copper resistance phenotypes in Xanthomonas spp. in the southern Caribbean region. An earlier study highlighted a variant copLAB gene cluster found in one Trinidadian Xanthomonas campestris pv. campestris (Xcc) strain (BrA1), with <90% similarity to previously reported Xanthomonas copLAB genes. With only one report describing this copper resistance genotype, the current study investigated the distribution of the BrA1 variant copLAB gene cluster and previously reported forms of copper resistance genes in local Xanthomonas spp.

Methods

Xanthomonas spp. were isolated from black-rot infected lesions on leaf tissue from crucifer crops at intensively farmed sites with high agrochemical usage in Trinidad. The identity of morphologically identified isolates were confirmed using a paired primer PCR based screen and 16s rRNA partial gene sequencing. MGY agar amended with CuSO4.5H2O up to 2.4 mM was used to establish MIC’s for confirmed isolates and group strains as sensitive, tolerant, or resistant to copper. Separate primer pairs targeting the BrA1 variant copLAB genes and those predicted to target multiple homologs found in Xanthomonas and Stenotrophomonas spp. were used to screen copper resistant isolates. Select amplicons were sanger sequenced and evolutionary relationships inferred from global reference sequences using a ML approach.

Results

Only four copper sensitive/tolerant Xanthomonas sp. strains were isolated, with 35 others classed as copper-resistant from a total population of 45 isolates. PCR detection of copLAB genes revealed two PCR negative copper-resistant resistant strains. Variant copLAB genes were only found in Xcc from the original source location of the BrA1 strain, Aranguez. Other copper-resistant strains contained other copLAB homologs that clustered into three distinct clades. These groups were more similar to genes from X. perforans plasmids and Stenotrophomonas spp. chromosomal homologs than reference Xcc sequences. This study highlights the localisation of the BrA1 variant copLAB genes to one agricultural community and the presence of three distinct copLAB gene groupings in Xcc and related Xanthomonas spp. with defined CuSO4.5H2O MIC. Further characterisation of these gene groups and copper resistance gene exchange dynamics on and within leaf tissue between Xcc and other Xanthomonas species are needed as similar gene clusters showed variable copper sensitivity profiles. This work will serve as a baseline for copper resistance gene characterisation in Trinidad and the wider Caribbean region and can be used to boost already lacking resistant phytopathogen management in the region.
Bioeconomia do bambu nativo, Guadua spp. do Acre, Amazônia, Brasil
Authors: Bayma Márcio Muniz Albano , Pereira Jonny Everson Scherwinski , Do Amaral Eufran Ferreira , Siviero Amauri , De Oliveira Luís Cláudio , Malavazi Fernando Wagner , Moret Artur de Souza
Published: June 2023

Um dos principais desacordos entre a economia e a ecologia, sob ponto de vista ecológico, deriva do fato de que a natureza tem processos cíclicos, enquanto os sistemas produtivos são pensados linearmente, sem considerar que todo sistema tem entradas e saídas. As atividades econômicas extraem recursos naturais e transformam-nos em produtos e resíduos, em seguida transacionam esses produtos aos consumidores, que descartam ainda mais resíduos depois do consumo. Tal modelo precisa ser revisto diante do cenário exaurido já em alguns biomas, em função de intensos modelos de exploração econômica. Esta pesquisa analisa o potencial bioeconômico da oferta natural de bambu nativo no estado do Acre, Brasil. As florestas de bambu dominam as paisagens do Acre ocupando as tipologias florestais que ocorrem em 62% do território acreano. Em campo foi obtido através de inventários florestais o número de hastes áreas por tipologia florestal: Os resultados revelam um potencial de receita de 5,2 bilhões de dólares, rentabilidade a ser obtida através do fornecimento de matéria prima para a indústria moveleira, construção civil, energética, dentre outros segmentos produtivos, que utilizam está biomassa à base de bambu.
Back to Square One: Attempted Legal Amendments and Abortion Practices in Sri Lanka
Authors: Silva Indralal W. De , Suranga M. Suchira S. , Kumarasinghe Malith
Published: June 2023

The Sri Lankan law only permits induced or iatrogenic abortion to save the life of the mother. Despite the restricted law, law enforcement mechanisms, and reported high national contraceptive prevalence rate, a significant proportion of pregnant women terminate their pregnancy outside the law. Despite the existence of restrictions and inertia, numerous stakeholders concerned about women’s health have made several attempts to liberalize the abortion law in Sri Lanka. Although several amendments were proposed to rationalize the abortion law in Sri Lanka, nothing has been successful – we are back to square one.

Expansion of legal exceptions for induced abortions and improved safe abortion with the revolutionized medical abortion (MA) were observed in numerous countries globally during the past decade. On the other hand, some countries with broadly liberal laws, including the United States, have added restrictions. How these global changes have affected countries like Sri Lanka is worth studying. This article assesses the response of the Sri Lankan government and the society towards those global changes in terms of the policies and practices on induced abortion. Authors argue that the paradigm shift in abortion practices in Sri Lanka, driven by the emerging occurrence of medical abortion, has highlighted the disparity between the existing legal status and the aspirations of most Sri Lankans. Given the widespread support for legalizing abortion in cases of rape, incest, and fetal abnormalities, it is imperative the government seriously consider legal amendments.
A Finite Mixture of Convex Combination of Probability Models: Properties and Application
Authors: Sakthivel K. M. , Vidhya G.
Published: June 2023

In this paper, a new continuous probability distribution is developed by using a mixture of exponential and Rayleigh distributions for modeling lifetime data. It has been developed to increase flexibility and shows it can perform better than the existing mixture distributions. The forms of the probability density function and cumulative distribution function along with statistical properties such as moments, incomplete moments, survival function, hazard function, mean residual life, stochastic ordering, order statistics, and stress strength reliability of the proposed distribution are explained. We also obtained the Bonferroni index and Lorenz curve of the proposed distribution. The parameters of the proposed distribution are estimated using the maximum likelihood technique. Finally, data analysis is performed using real-time data to illustrate the suitability of the proposed distribution.
Vaccine Coverage: Resurgence of Measles Outbreak in Ghana
Authors: Amankwa Abdul-Mumin , Abdulai Yahaya , Offei Kwesibea , Malik Yussif Abdul , Adam Yushawu Adankah
Published: June 2023

Measles is a highly contagious viral disease that can lead to severe complications and even death, especially in young children. Children who are not vaccinated against measles are at a higher risk of contracting the disease. In the first 5 weeks of 2023, a total of 209 suspected cases were reported in 11 districts and they were all later confirmed to be positive by laboratory investigations. The low vaccination coverage rates have contributed to the recent measles outbreak in Ghana, which has had devastating consequences on children's health. The outbreak has been linked to several factors, including low immunization coverage, poor healthcare infrastructure, and inadequate disease surveillance systems. Improving vaccination coverage and strengthening surveillance and monitoring systems are critical steps in controlling and preventing the spread of measles.
Protective Efficiency of Pterocarpus erinaceus Leaves Extract in Carbon-tetrachloride-induced Hepatic and Hematological Injuries in Rats
Authors: Mohammed Usman , Mohammed Abdulrashid , Mhya Daniel Hassan , Gabriel Simon Mafulul , Dahiru Daniel
Published: June 2023

Aims: Chemical toxicity is one of the major leading causes of tissues injuries, which impair the tissue’s ability to maintain normal physiological functions. Pterocarpus erinaceus is a medicinal plant use as traditional remedy for the treatment of several disorders associated with tissues injuries. This study therefore aimed at investigating tissues protective efficiency of Pterocarpus erinaceus leaves extract in carbon-tetrachloride-induced hepatic and hematological injuries in rats.

Materials and Methods: Leaves of Pterocarpus erinaceous after collection were air-dried and pulverized. It was extracted with methanol and the methanolic extracts were used. Acute toxicity and hepatoprotective studies against CCl4 toxicity were conducted. Rats were grouped into; Group 1: Normal control (liquid paraffin, vehicle 1ml.kg), Group 2: Negative control (received 1ml/kg CCl4), Group 3: Positive control (received 1ml/kg CCl4 +100ml/kg Silymarin), Group 4-6: Extract treated rats (received 1ml/kg CCl4 + varied doses of Extracts at 100, 200, and 400mg/kg body weight of rats). The treatment was done daily via oral means for 14 days.

Results: The results of the acute toxicity study showed Pterocarpus erinaceus extract safe with LD50 greater than 5000mg/kg body weight. This study reveals Pterocarpus erinaceus able to ameliorate CCl4 toxicity by minimizing damage to hepatic and hematological tissues. Histological study of the rats’ hepatic cells further unveils the protective ability of the plant extract against severity of CCl4-mediate hepatic architectural damage.

Conclusion: Pterocarpus erinaceus leaves possess components with tissue-protective properties hence the need to harness it for utilization.
Waste in intensive care unit in the view of professionals by Bardin's methodology / O desperdício em uma unidade de terapia intensiva na visão dos profissionais pela metodologia de Bardin
Authors: Sodré Sarah Lopes Silva , Silva Roberto Carlos Lyra da , Bertolossi Marta Cristiano , De Freitas Peregrino Antônio Augusto , Santiago Luiz Carlos , Schutz Vivian
Published: June 2023

Objetivo: Avaliar a opinião dos profissionais de saúde sobre o desperdício, em uma Unidade de Terapia Intensiva. Método: O método utilizado foi o qualitativo. Foi realizada uma entrevista com 66 profissionais de uma Unidade de Terapia Intensiva e analisados pela método de Bardin. Resultados: Através dos discursos obtidos em cada quadro, foram identificadas e destacadas as unidades de registro que permitiram a criação de dois quadros, o primeiro possibilitou a construção da categoria que denominada “Gestão de custos em saúde: o desperdício de materiais em UTI”. Já o quadro 2, possibilitou a obtenção de duas categorias, “Capacitação profissional em saúde: a otimização da gestão de custos em UTI” e “a inserção do processo de gestão de custos em UTI”. Conclusão: O primeiro passo para o combate ao desperdício é conhecer a realidade institucional. Os gestores necessitam conhecer as fontes de desperdício de seu serviço e o impacto desses nos custos.
Exposure to Agent Orange and Risk of Bladder Cancer Among US Veterans
Authors: Williams Stephen B. , Janes Jessica L. , Howard Lauren E. , Yang Ruixin , De Hoedt Amanda M. , Baillargeon Jacques G. , Kuo Yong-Fang , Tyler Douglas S. , Terris Martha K. , Freedland Stephen J.
Published: June 2023

Importance

To date, limited data exist regarding the association between Agent Orange and bladder cancer, and the Institute of Medicine concluded that the association between exposure to Agent Orange and bladder cancer outcomes is an area of needed research.

Objective

To examine the association between bladder cancer risk and exposure to Agent Orange among male Vietnam veterans.

Design, Setting, and Participants

This nationwide Veterans Affairs (VA) retrospective cohort study assesses the association between exposure to Agent Orange and bladder cancer risk among 2 517 926 male Vietnam veterans treated in the VA Health System nationwide from January 1, 2001, to December 31, 2019. Statistical analysis was performed from December 14, 2021, to May 3, 2023.

Exposure

Agent Orange.

Main Outcomes and Measures

Veterans exposed to Agent Orange were matched in a 1:3 ratio to unexposed veterans on age, race and ethnicity, military branch, and year of service entry. Risk of bladder cancer was measured by incidence. Aggressiveness of bladder cancer was measured by muscle-invasion status using natural language processing.

Results

Among the 2 517 926 male veterans (median age at VA entry, 60.0 years [IQR, 56.0-64.0 years]) who met inclusion criteria, there were 629 907 veterans (25.0%) with Agent Orange exposure and 1 888 019 matched veterans (75.0%) without Agent Orange exposure. Agent Orange exposure was associated with a significantly increased risk of bladder cancer, although the association was very slight (hazard ratio [HR], 1.04; 95% CI, 1.02-1.06). When stratified by median age at VA entry, Agent Orange was not associated with bladder cancer risk among veterans older than the median age but was associated with increased bladder cancer risk among veterans younger than the median age (HR, 1.07; 95% CI, 1.04-1.10). Among veterans with a diagnosis of bladder cancer, Agent Orange was associated with lower odds of muscle-invasive bladder cancer (odds ratio [OR], 0.91; 95% CI, 0.85-0.98).

Conclusions and Relevance

In this cohort study among male Vietnam veterans, there was a modestly increased risk of bladder cancer—but not aggressiveness of bladder cancer—among those exposed to Agent Orange. These findings suggest an association between Agent Orange exposure and bladder cancer, although the clinical relevance of this was unclear.
Guanidinate Ligand Stabilized Alkaline Earth Metal Complexes, Synthesis, Reactivity, and Catalytic Applications
Authors: Mukhopadhyay Sayantan , Rajput Sagrika , Nembenna Sharanappa
Published: June 2023

Guanidines are important organic components in terms of their multidimensional application, such as crucial synthons in organic chemistry, potential Lewis basic nature, and finally, acts as a versatile ligand in the field of coordination chemistry. Its variational coordination modes with different metals across the periodic table are well summarized in the literature. Though the transition elements take the lead in the guanidinate metal chemistry, there are some reports on the main group metal guanidinate complexes. This piece of work summarizes a detailed study of the recent advances in the coordination chemistry of guanidinate alkaline earth metal complexes and their catalytic applications.
The Development of Metal‐Based Antioxidants as Anticancer Agents
Authors: Nilewar Shrikant , Afroz Tahmina , Dunn Sarah , Del Bosque Nora , Green Kayla N.
Published: June 2023

Cancer continues to be a worldwide challenge for therapeutic design. Metal complexes have played a strong role as anticancer agents and they continue to be explored thanks to their versatility and success to date. Recent studies have shown that delivery of an antioxidant concomitant to chemotherapy enhances positive patient outcomes. While metal complexes with antioxidant activity are abundant, the number of studies of such compounds with anticancer activity is low. As a result of this and other studies, dual‐acting antioxidant and anticancer agents are gaining interest. Examples of these studies are presented focusing on the coordination chemistry, anticancer results, and antioxidant mechanisms for complexes reported since 2015.
Epilepsy in hypothalamic hamartomas: semiology spectrum and predictor analyses of 78 patients
Authors: Wang Xiu , Liu Chang , Zheng Zhong , Hu Wenhan , Zhang Chao , Yang Xiaoli , Shao Xiaoqiu , Zhang Jian‐Guo , Zhang Kai
Published: June 2023

Objective

To assess seizure semiology and disease evolution in a large number of hypothalamic hamartoma (HH) patients.

Methods

Seizure semiology and associated medical records for 78 patients with HH‐related epilepsy were retrospectively reviewed. Potential predictors of seizure types were assessed through univariate and binary logistic regression analyses.

Results

57 (73.1%) patients presented with gelastic seizures at the onset of epilepsy, of whole 39 (68.4%) experienced additional seizure types with a mean latency interval of 4.59 years. Automatism, version, and sGTCs were increasingly common with disease evolution. The intraventricular size of HH was significantly negatively correlated with the disease evolution interval (r = −0.445,p = 0.009). A significantly higher rate of patients with automatism in the DF‐II group relative to the DF‐III group was found in bothχ2(X = 6.07,p = 0.014) and logistic regression analyses (B = 3.196,p = 0.020).

Interpretation

Gelastic seizures are the most common initial seizure type in HH patients, but variable semiologies occur with disease evolution. The intraventricular HH lesion size is an important determinant of epilepsy evolution. DF‐II HH lesions contribute to a higher chance of automatism evolution. The present study furthers our understanding of the dynamic organization of the seizure network affected by HH.
Sex Differences in Pain and Quantitative Sensory Testing in Patients With Rheumatoid Arthritis
Authors: Vogel Kelly , Muhammad Lutfiyya N. , Song Jing , Neogi Tuhina , Bingham Clifton O. , Bolster Marcy B. , Marder Wendy , Wohlfahrt Alyssa , Clauw Daniel J. , Dunlop Dorothy , Lee Yvonne C.
Published: June 2023

Objective

Women with rheumatoid arthritis (RA) have higher pain and worse functional outcomes compared to men, even when treated with similar medications. The objective of this study was to identify sex differences in pain intensity, pain interference, and quantitative sensory tests (QST), which are independent of inflammation, in patients with RA.

Methods

This study is a post hoc analysis of participants in the Central Pain in Rheumatoid Arthritis cohort. Pain intensity was assessed using a 0–10 numeric rating scale. Pain interference was measured using a Patient‐Reported Outcomes Measurement Information System computerized adaptive test. QST included pressure pain detection thresholds, temporal summation, and conditioned pain modulation. Women and men were compared using multiple linear regression, adjusted for age, education, race, research site, depression, obesity, RA disease duration, swollen joint count, and C‐reactive protein.

Results

Mean ± SD pain intensity was 5.32 ± 2.29 among women with RA, compared to 4.60 ± 2.23 among men with RA (adjusted difference 0.83 [95% confidence interval (95% CI) 0.14, 1.53]). Women with RA had lower pressure pain detection thresholds at the trapezius (adjusted difference –1.22 [95% CI –1.73, –0.72]), wrist (adjusted difference –0.57 [95% CI –1.07, –0.06]), and knee (adjusted difference –1.10 [95% CI –2.00, –0.21]). No statistically significant differences in pain interference, temporal summation, and conditioned pain modulation were observed.

Conclusion

Women reported higher pain intensity and lower pressure pain detection thresholds (higher pain sensitivity) than men. However, pain interference, temporal summation, and conditioned pain modulation did not differ between men and women.

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An Efficient Intercalation Supramolecular Structure for Photocatalytic CO2 Reduction to Ethylene Under Visible Light
Authors: Ning Chenjun , Yang Jiangrong , Bai Sha , Chen Guangbo , Liu Guihao , Shen Tianyang , Zheng Lirong , Xu Si‐Min , Kong Xianggui , Liu Bin , Zhao Yufei , Song Yu‐Fei
Published: June 2023

Photocatalytic CO2 reduction (CO2PR) into multi‐carbon products (especially C2H4) is a highly attractive route for global carbon cycle, however, which is seriously limited by sluggish C‐C coupling kinetics and competitive hydrogen evolution reaction (HER) and so on. Herein, the fabrication of a novel supramolecular assembly of NiAl‐Fe‐TCPP is reported by intercalating iron porphyrin (Fe‐TCPP) into NiAl‐layered double hydroxide (NiAl‐LDH), and the resultant NiAl‐Fe‐TCPP exhibit superior catalytic performance on CO2PR to C2H4 under visible light irradiation in presence of photosensitizer. A high C2H4 selectivity up to 93.4% in the carbon‐containing products with the production rate as high as 24.7 µmol h−1 can be achieved over NiAl‐Fe‐TCPP. The ex/in situ X–ray absorption spectoscopy (XAS) indicates that the electron transfer between NiAl‐LDH and Fe‐TCPP can promote the generation of low‐valence of Fe sites, resulting in the efficient production of C2H4. The spin‐polarized density functional theory (DFT) calculations find that the synergistic mechanism that CO2 molecules are activated to CO on NiAl‐LDH and then spilled to Fe‐TCPP and coupled to COCHO#, which is further reduced to C2H4, are feasible in the perspective of Gibbs free energy. Moreover, the strong host‐guest interactions between NiAl‐LDH and Fe‐TCPP lead to the promoted photocatalytic activity and superior cycle stability.
Direct and Rapid High‐Temperature Upcycling of Degraded Graphite
Authors: Li Tangyuan , Tao Lei , Xu Lin , Meng Taotao , Clifford Bryson Callie , Li Shuke , Zhao Xinpeng , Rao Jiancun , Lin Feng , Hu Liangbing
Published: June 2023

Recycling the degraded graphite is becoming increasingly important, which can helped conserve natural resources, reduce waste, and provide economic and environmental benefits. However, current regeneration methods usually suffer from the use of harmful chemicals, high energy and time consumption, and poor scalability. Herein, we report a continuously high‐temperature heating (≈2000 K) process to directly and rapidly upcycle degraded graphite containing impurities. A sloped carbon heater is designed to provide the continuous heating source, which enables robust control over the temperature profile, eliminating thermal barrier for heat transfer compared to conventional furnace heating. The upcycling process can be completed within 0.1 s when the degraded graphite rolls down the sloped heater, allowing us to produce the upcycled graphite on a large scale. High‐temperature heating removes impurities and enhances the graphitization degree and (002) interlayer spacing, making the upcycled graphite more suitable for lithium intercalation and deintercalation. The assembled upcycled graphite||Li cell displays a high reversible capacity of ≈320 mAh g−1 at 1 C with a capacity retention of 96% after 500 cycles, comparable to current state‐of‐the‐art recycled graphite. The method is a chemical‐free, rapid, and scalable way to upcycle degraded graphite, and is adaptable to recycle other electrode materials.
Creation of Nanotips on ITO Electrode by Nanoparticle Deposition: An Easy Way to Enhance the Performance of Electrically Responsive Photonic Crystal and Fabricate Electrically Triggered Anticounterfeiting Tags
Authors: Yu Wenyuan , Zhao Yanxuan , Sheng Wenting , Ge Jianping
Published: June 2023

Electrically responsive photonic crystals (ERPC) are promising materials for electrophoretic displays, smart windows, and tunable optical devices. However, the high working voltage limits the application of most polar ERPCs because it damages color saturation, response stability, and reversibility. Herein, an easy but general method based on the modification of electrodes with nanoparticles is developed to improve ERPC's performance. The deposition of Au, Cu, or Cu2O nanoparticles created nanotip structures on the electrode, which enhanced the charge injection and local electric field strength, lowered 43% of the working voltage, and increased the color saturation. Meanwhile, the lowered voltage inhibited the electrodeposition of colloidal particles and the electrochemical reaction, which also improved the stability and reversibility of the electrical response. Based on the region‐selective modification of the electrode and the resulting asymmetric electrical response, an electrically triggered tag with a “pattern showing/hiding” effect is fabricated for anticounterfeiting purposes.
Ultrafast Optical Control of Polariton Energy in an Organic Semiconductor Microcavity
Authors: McGhee Kirsty E. , Guizzardi Michele , Jayaprakash Rahul , Georgiou Kyriacos , Jessewitsch Till , Scherf Ullrich , Cerullo Giulio , Zasedatelev Anton , Virgili Tersilla , Lagoudakis Pavlos G. , Lidzey David G.
Published: June 2023

The manipulation of exciton–polaritons and their condensates is of great interest due to their applications in polariton simulators and high‐speed, all‐optical logic devices. Until now, methods of trapping and manipulating such condensates are not dynamically reconfigurable or resulted in an undesirable reduction in the exciton–photon coupling strength. Here, a new strategy for the ultrafast control of polariton resonances via transient modification of an optical cavity mode is presented. Multilayer organic semiconductor microcavities that contain two absorbers are constructed: one strongly‐coupled to the cavity photon mode and one that is out‐of‐resonance. By selectively exciting the out‐of‐resonance absorber using ultrashort laser pulses, the cavity refractive index is modulated, and fully‐reversible blueshifts of the lower polariton branch by up to 8 meV in sub‐ps timescales with no corresponding reduction in the exciton–photon coupling strength are generated. This work demonstrates the ability to manipulate polariton energy landscapes over ultrafast timescales with important applications in emerging computing technologies.
Synthesis of Bulky N‐Acyl Heterocycles by DMAPO/Boc2O‐Mediated One‐Pot Direct N‐Acylation of Less Nucleophilic N‐Heterocycles with α‐Fully Substituted Carboxylic Acids
Authors: Umehara Atsushi , Shimizu Soma , Sasaki Makoto
Published: June 2023

This report describes a general method for the one‐pot direct N‐acylation of N‐heterocycles using our previously developed 4‐(N,N‐dimethylamino)pyridine N‐oxide (DMAPO)/di‐tert‐butyl dicarbonate (Boc2O) system. This system enables one‐pot N‐acylation reactions to provide bulky N‐acyl heterocycles starting from a wide variety of less nucleophilic N‐heterocycles and sterically hindered α‐fully substituted carboxylic acids in high yields. Moreover, this one‐pot method does not involve pre‐activation of substrates. The protocol has been successfully extended to one‐pot N‐acylation of 7‐azaindoles.
Self‐Immolative Nanobody‐Cysteine Residue Modification for Controlled Immunodrug Delivery
Authors: Scherger Maximilian , Pilger Yannick A. , Stickdorn Judith , Komforth Patric , Schmitt Sascha , Arnouk Sana M. , Lebegge Els , Koynov Kaloian , Räder Hans‐Joachim , Van Ginderachter Jo A. , Nuhn Lutz
Published: June 2023

Applications of antibody‐drug conjugates are rapidly growing, however, arduous fabrication of antibodies and impairment of highly potent drugs by covalent fixation to the protein is urging for alternatives to these conventional strategies. Here, a procedure on genetically engineered single domain antibodies, so‐called nanobodies, is demonstrated for their site‐specific reversible bioconjugation using self‐immolative linkers (SILs). Straight‐forward fluorescent labelling at their C‐terminal cysteine can be reversed under reductive conditions due to its disulfide‐containing SIL. Flow cytometry and microscopy images demonstrate cellular uptake and confirm the integrity of the nanobodies’ biological affinity notwithstanding being modified. Following this strategy, a potent small molecular immunomodulator can be installed and its stimulatory effect on a cellular level is boosted in vitro compared to non‐degradable alternatives. Furthermore, this protocol is extended to further therapeutically relevant representatives of nanobodies, underlining the versatility of this reversible reductive‐responsive bioconjugation for a broad field of applications.
Facet‐Termination Promoted Uniform Zn (100) Deposition for High‐Stable Zinc‐Ion Batteries
Authors: Wang Yifan , Mo Li'e , Zhang Xianxi , Ren Yingke , Wei Tingting , Li Zhaoqian , Huang Yang , Zhang Hong , Cao Guozhong , Hu Linhua
Published: June 2023

Reversibility, usually evaluated by Coulombic efficiency (CE) and limited by dendrite growth, has become the major roadblock toward the widespread commercialization of zincion batteries. Tailoring the Zn deposition behavior is vital to prevent dendrite growth. In this work, the facet‐terminator serine is introduced to modulate the interface and obstruct the rampant growth of the Zn (100) plane. The serine cation (Ser+) is revealed to preferentially adsorb onto the electrode/electrolyte interface, suppressing the interfacial parasitic reaction. Theoretical analysis and postmortem/operando experimental techniques indicate that the Ser+ bestows (100)‐dominated morphology to zinc anodes, enabling a highly reversible and dendrite‐free Zn anode. These features endow the Zn anode with a long cyclic life of more than 800 h for Zn//Zn batteries and a high average Coulombic efficiency of 99.8% at 5 mA cm−2 and 5 mAh cm−2 for Zn//Cu batteries. When assembling with commercial V2O5, the full battery delivers a high capacity of 345.1 mAh g−1 at 5 A g−1 with a retention of 74.1% over 2000 cycles.
Addressing diversity in the physician workforce through social determinants of medical education
Authors: Smith Teresa Y. , Landry Alden , Schneider Jeffrey I.
Published: June 2023

Social determinants of medical education are the most impactful aspects of recruiting, retaining, and producing the next generation of a diverse physician workforce. We can use the same framework well known to describe social determinants of health to identify social determinants that impact medical education learners and their ability to enter the workforce and succeed to completion. Efforts aimed at recruitment and retention should not exist in isolation and must be matched with those that continuously assess and evaluate the learning environment. The development of a climate where all can bring their full selves to learn, study, work, and care for patients is critically important in the creation of a learning environment where every participant can grow and thrive. If we are to address the need to diversify the workforce, we must be intentional with strategic plans, which includes addressing the social determinants that are prohibitive for some of our learners.
Do Dutch farmers invest in expansion despite increased policy uncertainty? A participatory Bayesian network approach
Authors: Yanore Lotte , Sok Jaap , Oude Lansink Alfons
Published: June 2023

An important but understudied factor influencing strategic decisions of farmers is policy uncertainty. Increased policy uncertainty may expedite the timing of investments in expansion, a phenomenon that has been observed in the Dutch dairy sector in recent years. Using a participatory Bayesian network, we aimed to identify and assess the farm, farmer, and environmental characteristics that explain and predict investment strategies. The variable policy uncertainty is modeled as a multidimensional concept that is a function of objective and subjective variables. We found that the most important variables influencing investment timing are succession, risk attitude, perceived policy uncertainty, and earning capacity. The insights derived from this study are useful for policy advisors, finance providers, farm advisors, and also farmers themselves to enhance their understanding of why and when farm investments are likely to occur despite the high level of policy uncertainty. [EconLit Citations: Q180 Agricultural Policy; Food Policy; Animal Welfare Policy G410 Behavioral Finance: Role and Effects of Psychological, Emotional, Social, and Cognitive Factors on Decision Making in Financial Markets].
Readability and quality analysis of patient education materials in aspirin‐exacerbated respiratory disease
Authors: Panara Kush , Grose Elysia , Lee Daniel J. , Safadi Jenelle , Douglas Jennifer E. , Kohanski Michael A. , Palmer James N. , Lee John M. , Adappa Nithin D. , Bosso John V.
Published: June 2023

KEY POINTS

Patients are increasingly turning to online education materials to aid with disease management.

Patient education materials on aspirin‐exacerbated respiratory disease are of poor readability with significant room for improvement.
Myocardial‐Targeting Tannic Cerium Nanocatalyst Attenuates Ischemia/Reperfusion Injury
Authors: Wang Liping , Qiu Shuwen , Li Xi , Zhang Yabing , Huo Minfeng , Shi Jianlin
Published: June 2023

Ischemic heart disease (IHD) is one of the leading causes of death worldwide. Medications or surgery have been considered as effective protocols to treat IHD for decades. Yet the reperfusion of the blood flow frequently leads to the generation of excessive reactive oxygen species (ROS), causing prominent and irreversible damage to the cardiomyocytes. In the present work, tannic acid‐assembled tetravalent cerium (TA−Ce) nanocatalysts with appealing cardiomyocyte‐targeting and antioxidation capability have been synthesized and applied for the effective and biocompatible ischemia/reperfusion injury therapeutics. TA−Ce nanocatalysts could effectively rescue the cardiomyocytes from oxidative stress induced by H2O2 challenge as well as oxygen‐glucose deprivation in vitro. In the murine ischemia/reperfusion model, cardiac accumulation and intracellular ROS scavenging could be achieved against the pathology, substantially reducing the myocardial infarct area and recovering heart functionality. This work illuminates the design of nanocatalytic metal complexes and their therapeutic prospects in ischemic heart diseases with high effectiveness and biocompatibility, paving the way for the clinical translation from bench to bedside.
Improved Thermal and Chemical Stability of Oxynitride Phosphor from Facile Chemical Synthesis for Vehicle Cornering Lights
Authors: Wen Dawei , Liu Hongmin , Ma Zhe , Zhou Lei , Li Junhao , Guo Yue , Zeng Qingguang , Tanner Peter A. , Wu Mingmei
Published: June 2023

Orange Eu2+‐doped phosphors are essential for light‐emitting diodes for cornering lights to prevent fatal road accidents at night, but such phosphors require features of high thermal, chemical stability and facile synthesis. This study reports a series of yellow‐orange‐red emitting SrAl2Si3ON6:Eu2+ oxynitride phosphors, derived from the SrAlSi4N7 nitride iso‐structure by replacing Si4+−N3− with Al3+−O2−. The introduction of a certain amount of oxygen enabled the facile synthesis under atmospheric pressure using the air‐stable raw materials SrCO3, Eu2O3, AlN and Si3N4. SrAl2Si3ON6 has a smaller band gap and lower structure rigidity than SrAlSi4N7 (5.19 eV vs 5.50 eV, Debye temperature 719 K vs 760 K), but exhibits higher thermal stability with 100 % of room temperature intensity remaining at 150 °C compared to 85 % for SrAlSi4N7. Electron paramagnetic resonance, thermoluminescence and density functional theory revealed that the oxygen vacancy electron traps compensated the thermal loss. Additionally, no decrease in emission intensity was found after either being heated at 500 °C for 2 hours or being immersed in water for 20 days, implying both of the thermal and chemical stability of SrAl2Si3ON6:Eu2+ phosphors. The strategy of oxynitride‐introduction from nitride promotes the development of low‐cost thermally and chemically stable luminescent materials.
Assessing the Value of Huddle Implementation in the Perioperative Setting
Authors: Thomas Tina , Hampton Debra , Butler Karen , Hudson Julie L.
Published: June 2023

Communication is essential for safe, effective patient care. In perioperative services, where interdisciplinary teamwork is crucial, communication breakdowns may lead to increased errors, decreased staff member satisfaction, and poor team performance. This process improvement project focused on instituting perioperative huddles for two months and measuring the effect that they had on staff members’ satisfaction, engagement, and communication effectiveness. We used validated, Likert‐style survey tools to gauge participants’ satisfaction, level of engagement, communication practices, and opinions about the value of huddles before and after implementation, in addition to an open‐ended descriptive question in the postsurvey. Sixty‐one participants completed the presurvey and 24 participants completed the postsurvey. Scores across all categories increased post huddle implementation. Benefits of the huddles noted by participants included timely and consistent messaging, sharing essential information, and increased feelings of connection between perioperative leaders and staff members.