bluuebunny/crossref_metadata_2025 huggingface dataset:
Monitoring Changes in Lower-Limb Strength and Power in Elite Athletes With the Countermovement-Jump and Keiser Leg-Press Tests
Authors: Nysether Sondre , Hopkins Will G. , Mentzoni Fredrik , Paulsen Gøran , Haugen Thomas A. , Solberg Paul A.
Published: July 2023

Purpose: To determine the utility of countermovement-jump and Keiser leg-press tests for tracking changes in elite athletes of different sports. Methods: Elite athletes of the Norwegian Olympic Federation (126 individuals from 18 sports) performed countermovement-jump and Keiser tests on 2 to 11 occasions between 2014 and 2021. Separate analyses were performed for male and female alpine skiing, male and female handball, male ice hockey, and males and females of other sports. Means and standard deviations of consecutive change scores were combined with short-term error of measurement (3.7%–7.0%) and smallest important changes (2.0%–3.6%, defined by standardization) to determine the proportions of athletes who experienced decisive changes in 2 senses: first, the athlete did not get substantially worse or better (>90% chance of either), and second, the athlete did get substantially worse or better (>90% chance of either). Results: Averaged over sports, Keiser peak power and relative peak power had the highest proportions of decisive changes in the first (60% and 55%) and second senses (25% and 28%). The velocity intercept of the force–velocity relationship had the lowest proportions in the first and second senses (29% and 11%), while jump height, Keiser mean power, relative mean power, the force intercept, and the slope of the force–velocity relationship had similar proportions (40%–53% and 15%–21%). Conclusions: With the possible exception of the Keiser test velocity intercept, the proportions of observed decisive changes in elite athletes using Keiser measures and countermovement-jump height between tests appear adequate for the measures to be useful for routine monitoring.
Systemic host inflammation induces stage-specific transcriptomic modification and slower maturation in malaria parasites
Authors: Lansink Lianne I. M. , Skinner Oliver P. , Engel Jessica A. , Lee Hyun Jae , Soon Megan S. F. , Williams Cameron G. , SheelaNair Arya , Pernold Clara P. S. , Laohamonthonkul Pawat , Akter Jasmin , Stoll Thomas , Hill Michelle M. , Talman Arthur M. , Russell Andrew , Lawniczak Mara , Jia Xiaoxiao , Chua Brendon , Anderson Dovile , Creek Darren J. , Davenport Miles P. , Khoury David S. , Haque Ashraful
Published: July 2023

Maturation rates of malaria parasites within red blood cells (RBCs) can be influenced by host nutrient status and circadian rhythm; whether host inflammatory responses can also influence maturation remains less clear. Here, we observed that systemic host inflammation induced in mice by an innate immune stimulus, lipopolysaccharide (LPS), or by ongoing acute
Plasmodium
infection, slowed the progression of a single cohort of parasites from one generation of RBC to the next. Importantly, plasma from LPS-conditioned or acutely infected mice directly inhibited parasite maturation during in vitro culture, which was not rescued by supplementation, suggesting the emergence of inhibitory factors in plasma. Metabolomic assessments confirmed substantial alterations to the plasma of LPS-conditioned and acutely infected mice, and identified a small number of candidate inhibitory metabolites. Finally, we confirmed rapid parasite responses to systemic host inflammation
in vivo
using parasite scRNA-seq, noting broad impairment in transcriptional activity and translational capacity specifically in trophozoites but not rings or schizonts. Thus, we provide evidence that systemic host inflammation rapidly triggered transcriptional alterations in circulating blood-stage Plasmodium trophozoites and predict candidate inhibitory metabolites in the plasma that may impair parasite maturation
in vivo
.

IMPORTANCE

Malaria parasites cyclically invade, multiply, and burst out of red blood cells. We found that a strong inflammatory response can cause changes to the composition of host plasma, which directly slows down parasite maturation. Thus, our work highlights a new mechanism that limits malaria parasite growth in the bloodstream.
Effectiveness of combined surgical and exercise-based interventions following primary traumatic anterior shoulder dislocation: a systematic review and meta-analysis
Authors: Chiddarwar Vaishnavi , de Zoete Rutger M J , Dickson Cameron , Lathlean Timothy
Published: July 2023

Objective

To investigate the effectiveness, risk of recurrence and return to activity (RTA) of surgery combined with exercise-based interventions (EBI) versus EBI alone after traumatic anterior shoulder dislocation (ASD).

Design

Systematic review and meta-analysis.

Data sources

Systematic literature search (MEDLINE, Web of Science, Scopus, Google Scholar).

Eligibility

Studies focused on EBI or EBI as a part of postoperative care for adults with an ASD, written in English, and published after 1990. We excluded diagnostic, assessment-based studies on individuals experiencing recurrent shoulder dislocations, concomitant shoulder injury, animal or cadaveric studies. Primary outcomes were dislocation RTA. Secondary outcomes were self-reported outcome measures, strength and range of motion. Random-effects meta-analysis was used to estimate the effect of EBI (SMD; Hedges’ g, RR). The Grading of Recommendations Assessment, Development and Evaluation approach was used to assess the certainty of evidence.

Results

Sixty studies were included (n=3598); seven were meta-analysed (n=345). The mean age of participants in the included studies was 26.71±9.19 and 56% of those included were male. Of the 60 studies included in the systematic review, 29 were fair quality (48.3%), 15 studies were good quality (25%) and 16 studies were poor quality (26.7%), (k=0.66). Individuals who underwent EBI alone were 2.03 times more likely to experience recurrent instability than individuals who underwent EBI in conjunction with surgery (RR 2.03, 95% CI 1.03 to 3.97). Individuals who underwent EBI with surgery appeared 1.81 times more likely to RTA than those who underwent EBI alone, although results were not statistically significant (RR 1.81, 95% CI 0.96 to 3.43).

Conclusions

Surgery combined with EBI is more effective in reducing the risk of recurrence and possibly increasing RTA than EBI alone after traumatic ASD.
Views of voluntary, temporary out-of-home firearm storage among individuals living in a firearm-owning home: results from a qualitative study in two states
Authors: Barnard Leslie M , Knoepke Christopher E , McCarthy Megan , Rowhani-Rahbar Ali , Siry-Bove Bonnie J , Betz Marian E
Published: July 2023

Introduction

Firearms account for the majority of suicide deaths in the USA. A recommended approach for suicide prevention is reducing access to firearms by temporarily removing them from the home. We sought to understand how firearm owners and those who reside with them view and might use voluntary, temporary out-of-home firearm storage.

Methods

From July to November 2021, we interviewed English-speaking adults in Colorado and Washington who own firearms or reside with them, using semistructured interviews. We used a team-based mixed deductive and inductive approach to code transcripts and identify themes.

Results

Half of the 38 interviewees were men (53%) aged 35–54 years (40%); 92% identified as white. The average age that participants reported first having a firearm was 20.4 years; 16% reported never owning a firearm themselves, only living in homes with firearms. Qualitative findings fell into broad themes: (1) storage with family members/friends, (2) concerns/challenges with storing a firearm with a business/organization, (3) importance of trust (4) outreach methods for out-of-home storage programmes.

Conclusion

Programmes for voluntary, temporary out-of-home firearm storage will not be impactful unless such storage is desired and used. Understanding views of potential storage users can help support development of acceptable and feasible programmes.
Concentrated disadvantage and functional disability: a longitudinal neighbourhood analysis in 100 US cities
Authors: Semenza Daniel , Silver Ian , Stansfield Richard , Boen Courtney
Published: July 2023

Background

Socioeconomic disadvantage related to poverty, unemployment and social disinvestment contributes to significant disparities in community health in the USA. Yet, there remains limited ecological research on the relationship between neighbourhood disadvantage and functional disability. Much of the work in this area has focused on elderly populations without attention to variation across age and sex groups.

Methods

Using a longitudinal dataset of almost 16 000 neighbourhoods, we examine the relationship between neighbourhood disadvantage and functional disability. Leveraging a series of cross-lagged panel models, we account for reciprocal dynamics and a range of pertinent covariates while assessing differences across age- and sex-specific groups.

Results

Accounting for reciprocal effects, we found that the association between concentrated disadvantage and functional disability varies across age and sex groups. Concentrated disadvantage is most consistently associated with increased functional disability among boys (5–17 years), young men (18–34 years) and middle-aged men (35–64 years). Similar associations are found among girls (5–17 years) and middle-aged women (35–64 years).

Conclusion

Local neighbourhood economic conditions are significantly associated with functional disability among relatively young populations of males and females. Exposure to neighbourhood disadvantage and deprivation may accelerate disablement processes and shift the age curve of disability risk.
The structure of the $$\mathcal{N}=4$$ supersymmetric linear $$W_{\infty }[\lambda ]$$ algebra
Authors: Ahn Changhyun
Published: July 2023

For the vanishing deformation parameter $$\lambda $$
λ
, the full structure of the (anti)commutator relations in the $$\mathcal{N}=4$$

N
=
4

supersymmetric linear $$W_{\infty }[\lambda =0]$$

W
∞

[
λ
=
0
]

algebra is obtained for arbitrary weights $$h_1$$

h
1

and $$h_2$$

h
2

of the currents appearing on the left hand sides in these (anti)commutators. The $$w_{1+\infty }$$

w

1
+
∞

algebra can be seen from this by taking the vanishing limit of other deformation parameter q with the proper contractions of the currents. For the nonzero $$\lambda $$
λ
, the complete structure of the $$\mathcal{N}=4$$

N
=
4

supersymmetric linear $$W_{\infty }[\lambda ]$$

W
∞

[
λ
]

algebra is determined for the arbitrary weight $$h_1$$

h
1

together with the constraint $$h_1-3 \le h_2 \le h_1+1$$

h
1

-
3
≤

h
2

≤

h
1

+
1

. The additional structures on the right hand sides in the (anti)commutators, compared to the above $$\lambda =0$$

λ
=
0

case, arise for the arbitrary weights $$h_1$$

h
1

and $$h_2$$

h
2

where the weight $$h_2$$

h
2

is outside of above region.
Molecular data needs for advanced collisional-radiative modelling for hydrogen plasmas
Authors: Bergmayr R. C. , Wünderlich D. , Fantz U.
Published: July 2023

Population models for molecular hydrogen (H2) are applicable in various fields of plasma physics and particularly in fusion research: they are necessary for the evaluation of plasma diagnostics (e.g. optical emission spectroscopy) or can be used to evaluate effective reaction rates for molecular processes (e.g. molecular-assisted recombination in divertor plasmas). The accuracy and completeness of population models for molecular hydrogen is strongly linked to the accuracy and availability of molecular reaction data. While there are recently huge improvements in the field of electron impact cross sections, the shortfalls regarding input data availability persist in the area of collisions between heavy particles and H2. An overview of the status of population models for H and H2 based on the Yacora solver is given. The data needs for collisional-radiative modelling are demonstrated by means of three examples comprising different detail levels, namely a purely electronic collisional-radiative model for the singlet system of H2, a corona model for the Fulcher-α band and a vibrationally resolved collisional-radiative model for the electronic ground state X1 of H2.

Graphical abstract
On the free convection of magneto-micropolar fluid in association with thermal radiation and chemical reaction and optimized heat transfer rate using response surface methodology
Authors: Baithalu Rupa , Mishra S. R.
Published: July 2023

An analysis is carried out for the free convection of magneto-micropolar liquid via a stretching surface for the inclusion of thermal radiation and chemical reaction. The transverse magnetic field is employed on the normal direction of flow with the impact of Peclet number relating to thermal and solutal transfer profiles. Referring to the current applications in several engineering problems, industrial applications, and more importantly the peristaltic pumping processes, blood flow phenomena, etc. the role of micropolar fluid is significant. Therefore, the objective of thismodel is to develop by incorporating thermal radiation which has several applications in aforesaid areas. However, the proposed model is solved analytically using the differential transform method (DTM) and prior to that transformation to ordinary system is obtained by using similarity transformations. The characteristic of various physical components associated with the governing equations is deployed graphically. The analysis of these parameters is described briefly in the discussion section. Further, a statistical approach response surface methodology (RSM) is used to optimize the heat transfer rate for the factors such as magnetic parameter, thermal radiation, and Peclet number.
Fast Loosely-Timed Deep Neural Network Models with Accurate Memory Contention
Authors: Arasteh Emad M. , Dömer Rainer
Published: July 2023

The emergence of data-intensive applications, such as Deep Neural Networks (DNN), exacerbates the well-known memory bottleneck in computer systems and demands early attention in the design flow. Electronic System-Level (ESL) design using SystemC Transaction Level Modeling (TLM) enables effective performance estimation, design space exploration (DSE), and gradual refinement. However, memory contention is often only detectable after detailed TLM-2.0 approximately-timed or cycle-accurate RTL models are developed. A memory bottleneck detected at such a late stage can severely limit the available design choices or even require costly redesign.

In this work, we propose a novel TLM-2.0 loosely-timed contention-aware (LT-CA) modeling style that offers high-speed simulation close to traditional loosely-timed (LT) models, yet shows the same accuracy for memory contention as low-level approximately-timed (AT) models. Thus, our proposed LT-CA modeling breaks the speed/accuracy tradeoff between regular LT and AT models and offers fast and accurate observation and visualization of memory contention.

Our extensible SystemC model generator automatically produces desired TLM-1 and TLM-2.0 models from a DNN architecture description for design space exploration focusing on memory contention. We demonstrate our approach with a real-world industry-strength DNN application, GoogLeNet. The experimental results show that the proposed LT-CA modeling is 46× faster in simulation than equivalent AT models with an average error of less than 1% in simulated time. Early detection of memory contentions also suggests that local memories close to computing cores can eliminate memory contention in such applications.
Faster Implementation of Ideal Lattice-Based Cryptography Using AVX512
Authors: Lei Douwei , He Debiao , Peng Cong , Luo Min , Liu Zhe , Huang Xinyi
Published: July 2023

With the development of quantum computing, the existing cryptography schemes based on classical cryptographic primitives will no longer be secure. Hence, cryptographers are designing post-quantum cryptographic (PQC) schemes, and ideal lattice-based cryptography has emerged as a prime candidate. Today, as ideal lattice-based cryptography becomes more mature, its performance becomes an important optimization goal. In ideal lattice-based cryptography, polynomial arithmetic and polynomial sampling are the most time-consuming operations and therefore need to be accelerated. In this article, taking advantage of the parallelism of new 512-bit advanced vector instructions (AVX512), we present parallel implementations of polynomial arithmetic and polynomial sampling, thus comprehensively improving their performance. We conduct experiments with the Dilithium scheme(one scheme of NIST PQC Standardization Process Round-4). Our implementation gets a nice performance boost compared to its pure C language and 256-bit advanced vector instructions (AVX2) implementation.
Discrete Listwise Content-aware Recommendation
Authors: Luo Fangyuan , Wu Jun , Wang Tao
Published: July 2023

To perform online inference efficiently, hashing techniques, devoted to encoding model parameters as binary codes, play a key role in reducing the computational cost of content-aware recommendation (CAR), particularly on devices with limited computation resource. However, current hashing methods for CAR fail to align their learning objectives (e.g., squared loss) with the ranking-based metrics (e.g., Normalized Discounted Cumulative Gain (NDCG)), resulting in suboptimal recommendation accuracy. In this article, we propose a novel ranking-based CAR hashing method based on Factorization Machine (FM), called
Discrete Listwise FM
(DLFM), for fast and accurate recommendation. Concretely, our DLFM is to
optimize NDCG in the Hamming space
for preserving the listwise user-item relationships. We devise an efficient algorithm to resolve the challenging DLFM problem, which can directly learn binary parameters in a relaxed continuous solution space, without additional quantization. Particularly, our theoretical analysis shows that the optimal solution to the relaxed continuous optimization problem is approximately the same as that of the original discrete optimization problem. Through extensive experiments on two real-world datasets, we show that DLFM consistently outperforms state-of-the-art hashing-based recommendation techniques.
On the Luminescence of HfGeO4:Ti4
+
X-ray Phosphor and Luminescence Thermometer
Authors: Jedoń Joanna , Pasiński Damian , Zych Eugeniusz
Published: July 2023

The HfGeO4:Ti phosphor was investigated, focusing on its thermoluminescence properties in the range of 30−500 °C and photoluminescence in the 13–600 K. The nominal Ti content was 1%, while 0.2% concentration was proved by EDS. The thermoluminescence exposed three TL peaks at 70, 120, and 180 °C whose properties were analyzed. Emissions peaking at 430 nm under 255 nm excitation, 580 nm under 320 nm, and 790 nm under 355 nm were identified and characterized. The latter two were not reported earlier. The 790 nm emission is suggested to result from slight contamination with rutile-TiO2. Contrary to the emission intensity, which slightly increased from 13 K to about 200 K, the decay time of the 430 nm luminescence started shortening at just about 40 K. The 580 and 790 nm luminescence is thermally quenched within ∼30–400 K range. Relative thermal sensitivity of 7.67%/K at 62 K (430 nm luminescence), and 6.04%/K at 73 K (580 nm) were achieved using decay time as the thermometric parameter. The HfGeO4:0.2%Ti appeared to be a very good luminescence thermometer operating in a wide range of 30–600 K, with sensitivities higher than 0.4%/K.
Neurovascular coupling and cerebrovascular hemodynamics are modified by exercise training status at different stages of maturation during youth
Authors: Talbot Jack S. , Perkins Dean R. , Dawkins Tony G. , Douglas Andrew J. M. , Griffiths Thomas D. , Richards Cory T. , Owen Kerry , Lord Rachel N. , Pugh Christopher J. A. , Oliver Jon L. , Lloyd Rhodri S. , Ainslie Philip N. , McManus Ali M. , Stembridge Mike
Published: July 2023

We report that the change in cerebral blood velocity during a neurovascular coupling task (NVC) is similar in pre- and postpubertal youth, regardless of exercise-training status. However, prepubertal untrained youth demonstrated a greater increase in cerebral blood pulsatility during the NVC task when compared with their trained counterparts. Our findings highlight that childhood represents a unique opportunity for exercise-mediated adaptations in cerebrovascular hemodynamics during NVC, which may confer long-term benefits in cerebrovascular function.
Central Sets Theorem Near of an Idempotent in Wap-Compactification
Authors: Pashapournia Ali , Akbari Tootkaboni Mohammad , Ebrahimi Bagha Davood
Published: July 2023

A small part of real line which is very close to zero has rich combinatorial properties. The aim of this paper is to express and then prove some locally combinatorial concepts near a virtual idempotent by considering the

wap

-compactification of a semitopological semigroup

S

. The

wap

-compactification of a semitopological semigroup

S

, denoted by

S

w

, is the collection of all ultrafilters near

η
∈

S

w

that forms a compact subsemigroup of

β

S

d

, where

S

d

denotes

S

as discrete space.
A Comprehensive Technoeconomic and Environmental Evaluation of a Hybrid Renewable Energy System for a Smart Farm in South Korea
Authors: Rabea Karim , Michailos Stavros , Udeh Godfrey T. , Park Jiseon , Lee YongWoon , Kim Seongil , Yang Won , Hughes Kevin J. , Ma Lin , Pourkashanian Mohamed
Published: July 2023

The farming sector like any other industry needs to be decarbonized. Hence, it is essential to meet the energy demands of the farms by adopting energy systems with a low-carbon footprint. Depending on the weather conditions, heating or cooling is needed. Within this context, this study presents a new hybrid renewable decentralized energy system that is designed to satisfy the requirements for heating, cooling, and electricity of a smart farm in South Korea. The under-investigation energy system comprises solar PV arrays, heat pumps, thermal energy storage tanks, and a wood pellet boiler. This study is the first to conduct an inclusive techno-enviroeconomic assessment of such a hybrid energy system by utilizing actual meteorological data on an hourly basis. This enables the model to be dynamic and facilitate accurate and reliable assessments. The modelling efforts have been performed in Aspen Plus and MATLAB to investigate the thermodynamic behaviour of the system. The investigation shows that the proposed system has achieved a daily average temperature of around 23.9°C inside the farm throughout the year with a standard deviation of 2.16°C. For the economic assessment, the levelized cost of energy has been selected as the main economic indicator, and this has been estimated at $0.218/kWh. It is found that the PV panels and the biomass boiler dominate the capital expenditures, and the biomass feedstock is the major contributor to the operating expenditures. Further, the proposed energy system reduces CO2 emissions, by up to 88.94%, when compared to conventional fossil-based energy systems. The outcomes of this study represent a holistic evaluation for such a low-carbon hybrid energy system when applied to greenhouses in Korea and in similar locations.
Prediction Model for Long-Term Bridge Bearing Displacement Using Artificial Neural Network and Bayesian Optimization
Authors: Asad Ali Turab , Kim Byunghyun , Cho Soojin , Sim Sung-Han
Published: July 2023

Bridge bearings are critical components in bridge structures because they ensure the normal functioning of bridges by accommodating the long-term horizontal movements caused by changing environmental conditions. However, abnormal structural behaviors in long-term horizontal displacement are observed when the structural integrity of bridge structures is degraded. This study aims to construct an accurate prediction model for long-term horizontal displacement under varying external environmental conditions to support the reliable assessment of bridge structures which has not been fully explored in previous studies. The main challenge in developing an accurate prediction model lies in modeling the influencing factors that accurately simulate the effect of external environmental conditions on long-term horizontal displacement. To enhance the prediction accuracy in the proposed study, the surrounding environmental effects by considering the relationship between the current and past displacements in addition to air temperature, thermal inertia, and solar radiation are modeled as critical influencing factors. In addition, a data-driven method based on an artificial neural network (ANN) integrated with Bayesian optimization (BO) is employed to model and predict long-term horizontal displacement with the adopted critical influencing factors. An overpass bridge equipped with bearing displacement monitoring and temperature sensors is used to validate the robustness and effectiveness of the proposed method. The analysis of the results concludes that the proposed method can generate an accurate and robust long-term horizontal displacement prediction model that supports a reliable anomaly detection approach for early warning systems of bridge structures.
Two Sites of Obstruction with Gallstones: A Case Report of Bouveret Syndrome with a Concurrent Biliary Ileus
Authors: Bergeron Eric , Pichette Maude
Published: July 2023

Bouveret syndrome is a gastric outlet obstruction, and biliary ileus is an obstruction of the small bowel, and both are caused by a gallstone that escaped the gallbladder through a bilio-enteric fistula. The concurrent occurrence of obstruction at both sites is encountered very rarely, and only two such cases associated with Bouveret syndrome were reported before. We now present a case involving a 78-year-old female with simultaneous obstruction at both the duodenum and jejunum. The literature is reviewed to evaluate the incidence of such a situation and to discuss the management of the case.
Supplementary Table 2 from Targeting CD44 Variant 5 with an Antibody–Drug Conjugate Is an Effective Therapeutic Strategy for Intrahepatic Cholangiocarcinoma
Authors: Bei Yuncheng , He Jian , Dong Xuhui , Wang Yuxin , Wang Sijie , Guo Wan , Cai Chengjie , Xu Zhiye , Wei Jia , Liu Baorui , Zhang Nan , Shen Pingping
Published: July 2023

amino acid sequences of mAbs in this study
Table S2 from Ccr2+ Monocyte-Derived Macrophages Influence Trajectories of Acquired Therapy Resistance in Braf-Mutant Melanoma
Authors: Kim Dahihm , An Luye , Moon Jiwon , Maymi Viviana I. , McGurk Alexander I. , Rudd Brian D. , Fowell Deborah J. , White Andrew C.
Published: July 2023

Primers used for quantitative real-time PCR (qRT-PCR)
Data from Wnt Signaling Stimulates Cooperation between GREB1 and HNF4α to Promote Proliferation in Hepatocellular Carcinoma
Authors: Matsumoto Shinji , Harada Akikazu , Seta Minami , Akita Masayuki , Gon Hidetoshi , Fukumoto Takumi , Kikuchi Akira
Published: July 2023

Abstract
Wnt signaling is known to maintain two cell states, hepatocyte differentiation and proliferation, in hepatocellular carcinoma (HCC). On the other hand, activation of Wnt signaling in colon cancer promotes uncontrollable stereotypic proliferation, whereas cells remain undifferentiated. To elucidate the unique mode of Wnt signaling in HCC, we comprehensively investigated HCC-specific Wnt pathway target genes and identified GREB1. Wnt signaling induced expression of GREB1 coupled with HNF4α and FOXA2, master transcription factors that maintain hepatic differentiation. Moreover, GREB1 was enriched at the regulatory region of atypical HNF4α target genes, including progrowth genes, thereby stimulating HCC proliferation. Therefore, GREB1 acts as a unique mediator of versatile Wnt signaling in HCC progression, bridging the roles of the Wnt pathway in differentiation and proliferation.
Significance:
GREB1 is a liver cancer–specific Wnt signaling target gene that induces an oncogenic shift of HNF4α, a putative tumor suppressor, and may represent a therapeutic target in Wnt-activated hepatocellular carcinoma.
Supplementary Table S3 from Outcomes in Patients with High-Risk Features after Fixed-Duration Ibrutinib plus Venetoclax: Phase II CAPTIVATE Study in First-Line Chronic Lymphocytic Leukemia
Authors: Allan John N. , Flinn Ian W. , Siddiqi Tanya , Ghia Paolo , Tam Constantine S. , Kipps Thomas J. , Barr Paul M. , Elinder Camburn Anna , Tedeschi Alessandra , Badoux Xavier C. , Jacobs Ryan , Kuss Bryone J. , Trentin Livio , Zhou Cathy , Szoke Anita , Abbazio Christopher , Wierda William G.
Published: July 2023

Representativeness Data
Supplementary Table S4 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
Authors: Cortellini Alessio , D'Alessio Antonio , Cleary Siobhan , Buti Sebastiano , Bersanelli Melissa , Bordi Paola , Tonini Giuseppe , Vincenzi Bruno , Tucci Marco , Russo Alessandro , Pantano Francesco , Russano Marco , Stucci Luigia Stefania , Sergi Maria Chiara , Falconi Martina , Zarzana Maria Antonietta , Santini Daniele , Spagnolo Francesco , Tanda Enrica T. , Rastelli Francesca , Giorgi Francesca Chiara , Pergolesi Federica , Giusti Raffaele , Filetti Marco , Lo Bianco Francesca , Marchetti Paolo , Botticelli Andrea , Gelibter Alain , Siringo Marco , Ferrari Marco , Marconcini Riccardo , Vitale Maria Giuseppa , Nicolardi Linda , Chiari Rita , Ghidini Michele , Nigro Olga , Grossi Francesco , De Tursi Michele , Di Marino Pietro , Queirolo Paola , Bracarda Sergio , Macrini Serena , Inno Alessandro , Zoratto Federica , Veltri Enzo , Spoto Chiara , Vitale Maria Grazia , Cannita Katia , Gennari Alessandra , Morganstein Daniel L. , Mallardo Domenico , Nibid Lorenzo , Sabarese Giovanna , Brunetti Leonardo , Perrone Giuseppe , Ascierto Paolo A. , Ficorella Corrado , Pinato David J.
Published: July 2023

NSCLC cohort - summary of baseline characteristics’ distribution after the propensity score matching procedure between patients on diabetes medications and those who were not receiving diabetes medications (ratio 1:1, caliper 0.1).
Supplementary Figure S1 from Type 2 Diabetes Mellitus and Efficacy Outcomes from Immune Checkpoint Blockade in Patients with Cancer
Authors: Cortellini Alessio , D'Alessio Antonio , Cleary Siobhan , Buti Sebastiano , Bersanelli Melissa , Bordi Paola , Tonini Giuseppe , Vincenzi Bruno , Tucci Marco , Russo Alessandro , Pantano Francesco , Russano Marco , Stucci Luigia Stefania , Sergi Maria Chiara , Falconi Martina , Zarzana Maria Antonietta , Santini Daniele , Spagnolo Francesco , Tanda Enrica T. , Rastelli Francesca , Giorgi Francesca Chiara , Pergolesi Federica , Giusti Raffaele , Filetti Marco , Lo Bianco Francesca , Marchetti Paolo , Botticelli Andrea , Gelibter Alain , Siringo Marco , Ferrari Marco , Marconcini Riccardo , Vitale Maria Giuseppa , Nicolardi Linda , Chiari Rita , Ghidini Michele , Nigro Olga , Grossi Francesco , De Tursi Michele , Di Marino Pietro , Queirolo Paola , Bracarda Sergio , Macrini Serena , Inno Alessandro , Zoratto Federica , Veltri Enzo , Spoto Chiara , Vitale Maria Grazia , Cannita Katia , Gennari Alessandra , Morganstein Daniel L. , Mallardo Domenico , Nibid Lorenzo , Sabarese Giovanna , Brunetti Leonardo , Perrone Giuseppe , Ascierto Paolo A. , Ficorella Corrado , Pinato David J.
Published: July 2023

Kaplan-Meier survival estimates according to the receipt of any diabetes medication. A) Overall Survival NSCLC matched cohort; patients on any diabetes medication: 14.2 months (95%CI: 9.0 – 17.5; 99 events), patients not receiving diabetes medications: 17.5 months (95%CI: 14.2 – 26.6; 77 events). B) Progression Free Survival NSCLC matched cohort; patients on any diabetes medication: 7.9 months (95%CI: 5.4 – 10.8; 113 events), patients not receiving diabetes medications: 10.1 months (95%CI: 7.7 – 13.8; 99 events). C) Overall Survival Melanoma matched cohort; patients on any diabetes medication: 22.9 months (95%CI: 12.0 – NR; 25 events), patients not receiving diabetes medications: NR months (95%CI: 28.8 – NR; 52 events). D) Progression Free Survival Melanoma matched cohort; patients on any diabetes medication: 11.4 months (95%CI: 4.9 – 23.4; 37 events), patients not receiving diabetes medications: 13.8 months (95%CI: 8.7 – 26.0; 77 events). NR: not reached; PSM: propensity score matching.
Supplementary Table S4 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: July 2023

Table S4. Hazard ratio of disease-free survival, overall survival, time to recurrence by quartiles of predicted vitamin D score
Supplementary Figure S3 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: July 2023

Figure S3. Multivariable hazard ratio and 95% confidence intervals for disease-free survival (A), overall survival (B), and time to recurrence (C), comparing plasma 25-hydroxyvitamin D ≥12 versus <12 ng/ml, across strata of potential effect modifiers
Supplementary Figure S2 from Plasma 25-Hydroxyvitamin D Levels and Survival in Stage III Colon Cancer: Findings from CALGB/SWOG 80702 (Alliance)
Authors: Wang Qiao-Li , Ma Chao , Yuan Chen , Shi Qian , Wolpin Brian M. , Zhang Yin , Fuchs Charles S. , Meyer Jeffrey , Zemla Tyler , Cheng En , Kumthekar Priya , Guthrie Katherine A. , Couture Felix , Kuebler Philip , Kumar Pankaj , Tan Benjamin , Krishnamurthi Smitha , Goldberg Richard M. , Venook Alan , Blanke Charles , Shields Anthony F. , O'Reilly Eileen M. , Meyerhardt Jeffrey A. , Ng Kimmie
Published: July 2023

Figure S2. Dose-response relationship and test of linearity for the hazard ratio (HR) of disease-free survival (A), overall survival (B), and time to recurrence (C) by continuous predicted vitamin D scores, with reference of plasma 25-hydroxyvitamin D set at 12 ng/ml
Supplementary Figure S4. from Multi-Maintenance Olaparib Therapy in Relapsed, Germline BRCA1/2-Mutant High-Grade Serous Ovarian Cancer (MOLTO): A Phase II Trial
Authors: Morgan Robert D. , Clamp Andrew R. , White Daniel J. , Price Marcus , Burghel George J. , Ryder W. David J. , Mahmood Reem D. , Murphy Alexander D. , Hasan Jurjees , Mitchell Claire L. , Salih Zena , Wheeler Chelsey , Buckley Emma , Truelove Joanna , King Georgia , Ainaoui Yasmina , Bhaskar Sanjeev S. , Shaw Joseph , Evans D. Gareth R. , Kilerci Bedirhan , Pearce Simon P. , Brady Gerard , Dive Caroline , O'Connor James P.B. , Wallace Andrew J. , Rothwell Dominic G. , Edmondson Richard J. , Jayson Gordon C.
Published: July 2023

Cell-free circulating DNA copy-number profiles.
Supplementary Figure 3 from Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes
Authors: Hwang Justin , Shi Xiaolei , Elliott Andrew , Arnoff Taylor E. , McGrath Julie , Xiu Joanne , Walker Phillip , Bergom Hannah E. , Day Abderrahman , Ahmed Shihab , Tape Sydney , Makovec Allison , Ali Atef , Shaker Rami M. , Toye Eamon , Passow Rachel , Lozada John R. , Wang Jinhua , Lou Emil , Mouw Kent W. , Carneiro Benedito A. , Heath Elisabeth I. , McKay Rana R. , Korn W. Michael , Nabhan Chadi , Ryan Charles J. , Antonarakis Emmanuel S.
Published: July 2023

AR activities and NEPC signatures in ATM- and BRCA2- mutated tumors.
Supplementary Figure 2 from Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes
Authors: Hwang Justin , Shi Xiaolei , Elliott Andrew , Arnoff Taylor E. , McGrath Julie , Xiu Joanne , Walker Phillip , Bergom Hannah E. , Day Abderrahman , Ahmed Shihab , Tape Sydney , Makovec Allison , Ali Atef , Shaker Rami M. , Toye Eamon , Passow Rachel , Lozada John R. , Wang Jinhua , Lou Emil , Mouw Kent W. , Carneiro Benedito A. , Heath Elisabeth I. , McKay Rana R. , Korn W. Michael , Nabhan Chadi , Ryan Charles J. , Antonarakis Emmanuel S.
Published: July 2023

Tumor mutation burden (muts/Mb) of ATM and BRCA2 mutant mPCs.
Supplementary Figure 1 from Metastatic Prostate Cancers with BRCA2 versus ATM Mutations Exhibit Divergent Molecular Features and Clinical Outcomes
Authors: Hwang Justin , Shi Xiaolei , Elliott Andrew , Arnoff Taylor E. , McGrath Julie , Xiu Joanne , Walker Phillip , Bergom Hannah E. , Day Abderrahman , Ahmed Shihab , Tape Sydney , Makovec Allison , Ali Atef , Shaker Rami M. , Toye Eamon , Passow Rachel , Lozada John R. , Wang Jinhua , Lou Emil , Mouw Kent W. , Carneiro Benedito A. , Heath Elisabeth I. , McKay Rana R. , Korn W. Michael , Nabhan Chadi , Ryan Charles J. , Antonarakis Emmanuel S.
Published: July 2023

Overall survival of ATM, BRCA2 mutant, and HRDother mPCs.
Supplementary Table S3 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Authors: Heiduk Max , Klimova Anna , Reiche Charlotte , Digomann David , Beer Carolin , Aust Daniela E. , Distler Marius , Weitz Jürgen , Seifert Adrian M. , Seifert Lena
Published: July 2023

Frequencies of CD8+ T cells, Tconv and Treg among all CD3+ T cells ± standard deviation according to clinicopathological parameters. Statistics (Stat.) with unpaired two-sided t-test or one-way ANOVA, respectively. *, P < 0.05
Supplementary Table S1 from Additional Oncogenic Alterations in RAS-Driven Differentiated Thyroid Cancers Associate with Worse Clinicopathologic Outcomes
Authors: Bikas Athanasios , Ahmadi Sara , Pappa Theodora , Marqusee Ellen , Wong Kristine , Nehs Matthew A. , Cho Nancy L. , Haase Jacob , Doherty Gerard M. , Sehgal Kartik , Barletta Justine A. , Alexander Erik K. , Landa Iñigo
Published: July 2023

Supplementary Table S1. List of all variants detected by Oncopanel in 78 RAS-mutant thyroid tumors
Supplementary Figure S2 from TIGIT Expression Delineates T-cell Populations with Distinct Functional and Prognostic Impact in Pancreatic Cancer
Authors: Heiduk Max , Klimova Anna , Reiche Charlotte , Digomann David , Beer Carolin , Aust Daniela E. , Distler Marius , Weitz Jürgen , Seifert Adrian M. , Seifert Lena
Published: July 2023

Survival analyses for clinicopathological parameters and for TIGIT and PD-1 expression in blood.
Data from Patient-Reported Outcomes as Interradiographic Predictors of Response in Non–Small Cell Lung Cancer
Authors: Bhatt Ambika S. , Schabath Matthew B. , Hoogland Aasha I. , Jim Heather S.L. , Brady-Nicholls Renee
Published: July 2023

AbstractPurpose:
Minimally invasive biomarkers have been used as important indicators of treatment response and progression in cancers such as prostate and ovarian. Unfortunately, all biomarkers are not prognostic in all cancer types and are often not routinely collected. Patient-reported outcomes (PRO) provide a non-obtrusive, personalized measure of a patient's quality of life and symptomatology, reported directly from the patient, and are increasingly collected as part of routine care. Previous literature has shown correlations between specific PROs (i.e., insomnia, fatigue) and overall survival. Although promising, these studies often only consider single time points and ignore patient-specific dynamic changes in individual PROs, which might be early predictors of treatment response or progression.
Experimental Design:
In this study, PRO dynamics were analyzed to determine if they could be used as interradiographic predictors of tumor volume changes among 85 patients with non–small cell lung cancer undergoing immunotherapy. PRO questionnaires and tumor volume scans were completed biweekly and monthly, respectively. Correlation and predictive analysis were conducted to identify specific PROs that could accurately predict patient response.
Results:
Changes in tumor volume over time were significantly correlated with dizziness (P < 0.005), insomnia (P < 0.05), and fatigue (P < 0.05). In addition, cumulative changes in insomnia could predict progressive disease with a 77% accuracy, on average 45 days prior to the next imaging scan.
Conclusions:
This study presents the first time that patient-specific PRO dynamics have been considered to predict how individual patients will respond to treatment. This is an important first step in adapting treatment to improve response rates.
Data from The GENIE BPC NSCLC Cohort: A Real-World Repository Integrating Standardized Clinical and Genomic Data for 1,846 Patients with Non–Small Cell Lung Cancer
Authors: Choudhury Noura J. , Lavery Jessica A. , Brown Samantha , de Bruijn Ino , Jee Justin , Tran Thinh Ngoc , Rizvi Hira , Arbour Kathryn C. , Whiting Karissa , Shen Ronglai , Hellmann Matthew , Bedard Philippe L. , Yu Celeste , Leighl Natasha , LeNoue-Newton Michele , Micheel Christine , Warner Jeremy L. , Ginsberg Michelle S. , Plodkowski Andrew , Girshman Jeffrey , Sawan Peter , Pillai Shirin , Sweeney Shawn M. , Kehl Kenneth L. , Panageas Katherine S. , Schultz Nikolaus , Schrag Deborah , Riely Gregory J.
Published: July 2023

AbstractPurpose:
We describe the clinical and genomic landscape of the non–small cell lung cancer (NSCLC) cohort of the American Association for Cancer Research (AACR) Project Genomics Evidence Neoplasia Information Exchange (GENIE) Biopharma Collaborative (BPC).
Experimental Design:
A total of 1,846 patients with NSCLC whose tumors were sequenced from 2014 to 2018 at four institutions participating in AACR GENIE were randomly chosen for curation using the PRISSMM data model. Progression-free survival (PFS) and overall survival (OS) were estimated for patients treated with standard therapies.
Results:
In this cohort, 44% of tumors harbored a targetable oncogenic alteration, with EGFR (20%), KRAS G12C (13%), and oncogenic fusions (ALK, RET, and ROS1; 5%) as the most frequent. Median OS (mOS) on first-line platinum-based therapy without immunotherapy was 17.4 months [95% confidence interval (CI), 14.9–19.5 months]. For second-line therapies, mOS was 9.2 months (95% CI, 7.5–11.3 months) for immune checkpoint inhibitors (ICI) and 6.4 months (95% CI, 5.1–8.1 months) for docetaxel ± ramucirumab. In a subset of patients treated with ICI in the second-line or later setting, median RECIST PFS (2.5 months; 95% CI, 2.2–2.8) and median real-world PFS based on imaging reports (2.2 months; 95% CI, 1.7–2.6) were similar. In exploratory analysis of the impact of tumor mutational burden (TMB) on survival on ICI treatment in the second-line or higher setting, TMB z-score harmonized across gene panels was associated with improved OS (univariable HR, 0.85; P = 0.03; n = 247 patients).
Conclusions:
The GENIE BPC cohort provides comprehensive clinicogenomic data for patients with NSCLC, which can improve understanding of real-world patient outcomes.
Poor Outcome in Postpartum Breast Cancer Patients Is Associated with Distinct Molecular and Immunologic Features
Authors: Lefrère Hanne , Moore Kat , Floris Giuseppe , Sanders Joyce , Seignette Iris M. , Bismeijer Tycho , Peters Dennis , Broeks Annegien , Hooijberg Erik , Van Calsteren Kristel , Neven Patrick , Warner Ellen , Peccatori Fedro Alessandro , Loibl Sibylle , Maggen Charlotte , Han Sileny N. , Jerzak Katarzyna J. , Annibali Daniela , Lambrechts Diether , de Visser Karin E. , Wessels Lodewyk , Lenaerts Liesbeth , Amant Frédéric
Published: July 2023

Purpose:

Patients with postpartum breast cancer diagnosed after cessation of breastfeeding (postweaning, PP-BCPW) have a particularly poor prognosis compared with patients diagnosed during lactation (PP-BCDL), or to pregnant (Pr-BC) and nulliparous (NP-BC) patients, regardless of standard prognostic characteristics. Animal studies point to a role of the involution process in stimulation of tumor growth in the mammary gland. However, in women, the molecular mechanisms that underlie this poor prognosis of patients with PP-BCPW remain vastly underexplored, due to of lack of adequate patient numbers and outcome data.

Experimental Design:

We explored whether distinct prognostic features, common to all breast cancer molecular subtypes, exist in postpartum tumor tissue. Using detailed breastfeeding data, we delineated the postweaning period in PP-BC as a surrogate for mammary gland involution and performed whole transcriptome sequencing, immunohistochemical, and (multiplex) immunofluorescent analyses on tumor tissue of patients with PP-BCPW, PP-BCDL, Pr-BC, and NP-BC.

Results:

We found that patients with PP-BCPW having a low expression level of an immunoglobulin gene signature, but high infiltration of plasma B cells, have an increased risk for metastasis and death. Although PP-BCPW tumor tissue was also characterized by an increase in CD8+ cytotoxic T cells and reduced distance among these cell types, these parameters were not associated with differential clinical outcomes among groups.

Conclusions:

These data point to the importance of plasma B cells in the postweaning mammary tumor microenvironment regarding the poor prognosis of PP-BCPW patients. Future prospective and in-depth research needs to further explore the role of B-cell immunobiology in this specific group of young patients with breast cancer.
Supplementary table 2 from Spectrum of Response to Platinum and PARP Inhibitors in Germline BRCA–Associated Pancreatic Cancer in the Clinical and Preclinical Setting
Authors: Stossel Chani , Raitses-Gurevich Maria , Atias Dikla , Beller Tamar , Glick Gorman Yulia , Halperin Sharon , Peer Eyal , Denroche Robert E. , Zhang Amy , Notta Faiyaz , Wilson Julie M. , O'Kane Grainne M. , Haimov Talmoud Elina , Amison Nora , Schvimer Michael , Salpeter Seth J. , Bar Vered , Zundelevich Adi , Tirosh Itay , Tal Rotem , Dinstag Gal , Kinar Yaron , Eliezer Yonatan , Ben-David Uri , Gavert Nancy S. , Straussman Ravid , Gallinger Steven J. , Berger Raanan , Golan Talia
Published: July 2023

Clinical data of analyzed BRCA PDAC patients