bluuebunny/crossref_metadata_2025 huggingface dataset:
Modelling Supply Chain Flexibility in the Indian Personal Hygiene Industry: An ISM-Fuzzy MICMAC Approach
Authors: Singh Rohit Kumar , Joshi Sudhanshu , Sharma Manu
Published: May 2020

With the changing business environment, firms are adopting flexible systems across their supply chains as a survival as well as a growth strategy. The aim of the article is to identity the key enablers of supply chain flexibility (SCF) adoption and to evaluate their fitness in the context of the personal hygiene industry in India. After a systematic literature review, 22 key dimensions of SCF have been extracted. A field investigation through interviews and a brainstorming session with industry experts have resulted in 11 dimensions, finally. Twenty-six experts participated in this interview and brainstorming session. These 11 dimensions have been exposed to interpretive structural modelling (ISM) to assess the hierarchal interaction among them. Fuzzy MICMAC has been employed to identify the driving dimensions of supply chain flexibility for the personal hygiene industry. The findings suggest that seven dimensions, namely process, manufacturing, sourcing, volume, market, new product development and coordination, have high dependence but weak driving power and are thus dependent on the other dimensions to influence the supply chain flexibility. Demand management and product flexibilities were found to have the strongest driving force and act as the key drivers for SCF. The originality of the conducted study lies in the multilevel hierarchical structure.
Perceiving Development Through Natives’ Lens: Field Experiences From Three Tribes of Arunachal Pradesh
Authors: Ramya Tame
Published: May 2020

Despite the acknowledgment that participatory approaches in development have potential in understanding and designing development programs and policies, perceptions of development continue to be dominated by outsiders including professionals and other development agents, most of whom do not experience the conditions. Using qualitative data collected based on the field experiences from three tribal communities of Kurung Kumey District, namely the Nyishi, the Puroik, and the Bangru, this article attempts to involve tribal community members in the conceptualization of development in their context and outlining possible strategies to address the identified development issues. The study finds people keen on participating in development and who can rank their development needs and priorities, emphasizing the significance of development, as well as its perceived hierarchical nature. The study advocates the use of both macro and micro approaches to development where development recipients are involved in development plans and decisions.
Progress of COVID-19 Epidemic in Pakistan
Authors: Abid Khadijah , Bari Yashfika Abdul , Younas Maryam , Tahir Javaid Sehar , Imran Abira
Published: May 2020

The outbreak of corona virus initiated as pneumonia of unknown cause in December 2019 in Wuhan, China, which has been now spreading rapidly out of Wuhan to other countries. On January 30, 2020, the World Health Organization (WHO) declared coronavirus outbreak as the sixth public health emergency of international concern (PHEIC), and on March 11, 2020, the WHO announced coronavirus as pandemic. Coronavirus is thought to be increasing in Pakistan. The first case of coronavirus was reported from Karachi on February 26, 2020, with estimated populace of Pakistan as 204.65 million. Successively, the virus spreads into various regions nationwide and has currently become an epidemic. The WHO has warned Pakistan that the country could encounter great challenge against the outbreak of coronavirus in the coming days. This short communication is conducted to shed light on the epidemic of coronavirus in the country. It would aid in emphasizing the up-to-date situation in a nutshell and the measures taken by the health sector of Pakistan to abate the risk of communication.
Bullying and the neoliberal university: A co-authored autoethnography
Authors: Zawadzki Michał , Jensen Tommy
Published: May 2020

The purpose of this article is to deepen the understanding of academic bullying as a consequence of neoliberal reforms in a university. Academics in contemporary universities have been put under pressure by the dominance of neoliberal processes, such as profit maximization, aggressive competitiveness, individualism or self-interest, generating undignifying social behaviours, including bullying practices. The presented story takes us – a junior academic and his conceptual encounterer – through our remembered experiences and field notes around a set of workday events in one European university reformed through managerial solutions as the object of the study. To do that, we employ co-authored analytic autoethnography to learn how neoliberal solutions reinforce paternalistic relationships as significant in career development, how such solutions enable the bullying of young academics and how neoliberalism in academia prevents young academics from contesting bullying. We are particularly interested in the bystander phenomenon: a person who shies away from taking action against bullying and thus strengthens bullying practices.
Listening to the autistic voice: Mental health priorities to guide research and practice in autism from a stakeholder-driven project
Authors: Benevides Teal W , Shore Stephen M , Palmer Kate , Duncan Patricia , Plank Alex , Andresen May-Lynn , Caplan Reid , Cook Barb , Gassner Dena , Hector Becca Lory , Morgan Lisa , Nebeker Lindsey , Purkis Yenn , Rankowski Brigid , Wittig Karl , Coughlin Steven S
Published: May 2020

Autistic adults are significantly more likely to experience co-occurring mental health conditions such as depression and anxiety. Although intervention studies are beginning to be implemented with autistic adults to address mental health outcomes, little is known about what research autistic adults feel is needed, or what mental health outcomes are of value to them. The purpose of this article is to describe a project that involved more than 350 autistic adults and other stakeholders as coproducers of research priorities on mental health. Through a variety of methods including a large online survey, two large stakeholder meetings, and three face-to-face focus groups, the project team identified five top priorities for mental health research which should be incorporated by researchers and practitioners in their work with autistic adults. These included research to inform trauma-informed care approaches; societal approaches for inclusion and acceptance of autistic individuals; community-available approaches for self-management of mental health; evaluation of adverse mental health outcomes of existing interventions; and improvements in measurement of quality of life, social well-being, and other preferred outcomes in autistic adults.

Lay Abstract

Autistic adults commonly experience mental health conditions. However, research rarely involves autistic adults in deciding priorities for research on mental healthcare approaches that might work for them. The purpose of this article is to describe a stakeholder-driven project that involved autistic adults in co-leading and designing research about priorities to address mental health needs. Through a large online survey, two large meetings, and three face-to-face focus group discussions involving over 350 stakeholders, we identified five priorities for mental health research desired by autistic adults. These priorities and preferred outcomes should be used to guide research and practice for autistic adults.
Looking good but feeling bad: “Camouflaging” behaviors and mental health in women with autistic traits
Authors: Beck Jonathan S , Lundwall Rebecca A , Gabrielsen Terisa , Cox Jonathan C , South Mikle
Published: May 2020

Autistic traits are associated with frequent psychological distress, suicidal ideation, and everyday functional challenges. These associations may be especially prominent in women. Some women with autistic traits “camouflage” feelings of awkwardness in typical social situations by effortfully engaging in expected social behaviors. We explored camouflaging because emerging evidence posits an association between camouflaging behaviors and poorer outcomes related to mental health, daily functioning, and access to mental health care. We recruited a sample of 58 women (age M = 25 years; IQ M = 115) who reported that they find social situations confusing and who scored high on a measure of broad autistic traits ( Broad Autism Phenotype Questionnaire score > 3). The majority of participants reported significant levels of psychological distress, suicidal ideation, and daily functioning difficulties. Regression models showed that camouflaging efforts ( Camouflaging Autistic Traits Questionnaire) and autistic traits ( Social Responsiveness Scale, Second Edition) modestly but significantly predicted psychological distress and functional challenges, respectively. In a subgroup of participants with high Camouflaging Autistic Traits Questionnaire scores, camouflaging scores were significantly associated with psychological distress and functional challenges. Camouflaging may help predict when clinicians should be concerned about higher mental health distress in autistic women and may be beneficial to measure as part of a comprehensive, multimethod assessment of mental health in women who report difficulties fitting into social situations.

Lay Abstract

Women who try to hide or “camouflage” their autistic traits are likely to report that they feel distressed, think of suicide, and/or struggle to function in everyday life. We asked 58 women with autistic traits to complete questionnaires about camouflaging and mental health. Most of these women did not have a formal diagnosis of autism, yet a majority reported that they camouflaged autistic traits, and a large majority reported significant mental health challenges. Some researchers have suggested that women with autistic traits are more likely than autistic men to experience mental health challenges because women may try more to “fit in” socially by camouflaging their autistic traits. Analyses showed that camouflaging was associated with feeling distressed (depressed, anxious, and/or stressed). For women who reported above-average levels of camouflaging, camouflaging was also associated with having thoughts about suicide and struggling to function in everyday life. Trying to camouflage autistic traits was associated with mental health challenges, regardless of whether those traits were very mild or more severe. The findings of this study may influence how mental health professionals evaluate and treat women with autistic traits.
A kinder, gentler drug war? Race, drugs, and punishment in 21st century America
Authors: Beckett Katherine , Brydolf-Horwitz Marco
Published: May 2020

This article assesses whether the kinder, gentler rhetoric through which the disproportionately white opiate crisis has been framed has been accompanied by changes in drug sentencing policy and drug law enforcement that mirror this sympathetic discourse. Toward these ends, state-level drug sentencing policies enacted from 2010 to 2016 as well as recent trends in drug law enforcement and drug-related imprisonment are analyzed. The legislative findings show that policymakers are not singling out opiate violations for particularly lenient treatment. Instead, it is the user/dealer distinction that animates recent shifts in drug policy: While state lawmakers are re-thinking their approach to drug possession, they are more likely to have enhanced penalties for drug distribution than to have reduced them. In addition, although significant racial disparities in arrests and incarceration persist, the main change that has occurred is a decline in the black share of arrests and imprisonments. The discussion explores possible explanations for these unexpected findings, including the possibility that political dynamics help explain the decline of the drug war in many urban areas and, as a result, the diminution of racial disparities in it.
When do generalists change more than specialists? Problem-driven and slack-driven change in labor allocation
Authors: Kim Yeojin , Rhee Mooweon
Published: May 2020

The existing literature has reached contradictory empirical conclusions regarding the tendency for generalist and specialist organizations to change their status quo. Some have posited that generalists are less likely to change than specialists, while others have posited the opposite. This article explores when generalists and specialists change their allocations of labor resources by delving into two different mechanisms: (1) how they perform (problem-driven mechanism) and (2) how much extra resources they possess (slack-driven mechanism). Based on empirical evidence collected in the agricultural industry in South Korea, we find that specialists are more likely to change in accordance with a problem-driven mechanism, whereas generalists are more prone to react to a slack-driven mechanism.
Student Retention at a Higher Educational Institution: A Comparison Between Evaded and Nonevaded Groups Using Partial Least Square
Authors: de Rosa Fernando , de Oliveira Thiago Luiz
Published: May 2020

Students’ desertions can be a threat to the proper functioning and management of a Higher Educational Institution. Based on the theoretical model named the Relationship Quality-based Student Loyalty that combines relationship marketing to educational studies retention constructs, the main objective of this study is the evaluation of the Relationship Quality-based Student Loyalty constructs in a Brazilian Higher Educational Institution reality and the identification of significant differences when evaded and nonevaded students groups are compared. A survey was carried out with 314 undergraduate students along with their secondary data. Data analysis was performed using Partial Least Square technique to test the model validity, Partial Least Square–Multiple Group Analysis to compare groups, and Mann–Whitney U test to identify significant differences in the parameters. Six of the eight hypotheses were entirely or partially confirmed. Those results can help educational managers to adopt a different positioning about student retention factors, in attempt to improve commitment and perceived quality.
Framing Automatic Voter Registration: Partisanship and Public Understanding of Automatic Voter Registration
Authors: Mann Christopher B. , Gronke Paul , Adona Natalie
Published: May 2020

Automatic voter registration (AVR) is a recent innovation in voter registration in the United States, passed by 18 states plus DC in the last 4 years. AVR has generally escaped partisan polarization about election reform, having passed in Republican and Democratic controlled states. Using a survey experiment in the 2018 Cooperative Congressional Election Study, we investigate effects of source cues about support of AVR from different party elites and from election administrators on the public’s expectations about AVR’s impact on turnout, voter fraud, fairness, and election problems. Our experimental results show an asymmetric partisan effect. When AVR is endorsed by Democratic leaders, Republicans (and independents) expect AVR to reduce the fairness and legitimacy of elections, while Democrats are generally resistant to partisan cues.
AEDs and Cognition: One Small Fish in a Very Large Pond?
Authors: Martin Roy C.
Published: May 2020

[Box: see text]
Forelimb Cortical Stroke Reduces Precision of Motor Control in Mice
Authors: Becker April M. , Betz Dene M. , Goldberg Mark P.
Published: May 2020

Background and Objective. Rodent models of stroke impairment should capture translatable features of behavioral injury. This study characterized poststroke impairment of motor precision separately from strength in an automated behavioral assay. Methods. We measured skilled distal forelimb reach-and-grasp motions within a target force range requiring moderate-strength. We assessed whether deficits reflected an increase in errors on only one or both sides of the target force range after photothrombotic cortical stroke. Results. Pull accuracy was impaired for 6 weeks after stroke, with errors redistributing to both sides of the target range. No decrease in maximum force was measured. Conclusions. This automated reach task measures sustained loss of motor precision following cortical stroke in mice.
Evaluation of convolutional neural networks for the classification of falls from heterogeneous thermal vision sensors
Authors: López-Medina Miguel Ángel , Espinilla Macarena , Nugent Chris , Quero Javier Medina
Published: May 2020

The automatic detection of falls within environments where sensors are deployed has attracted considerable research interest due to the prevalence and impact of falling people, especially the elderly. In this work, we analyze the capabilities of non-invasive thermal vision sensors to detect falls using several architectures of convolutional neural networks. First, we integrate two thermal vision sensors with different capabilities: (1) low resolution with a wide viewing angle and (2) high resolution with a central viewing angle. Second, we include fuzzy representation of thermal information. Third, we enable the generation of a large data set from a set of few images using ad hoc data augmentation, which increases the original data set size, generating new synthetic images. Fourth, we define three types of convolutional neural networks which are adapted for each thermal vision sensor in order to evaluate the impact of the architecture on fall detection performance. The results show encouraging performance in single-occupancy contexts. In multiple occupancy, the low-resolution thermal vision sensor with a wide viewing angle obtains better performance and reduction of learning time, in comparison with the high-resolution thermal vision sensors with a central viewing angle.
Intramedullary Headless Screw Fixation of Metacarpal Fractures: A Radiographic Analysis for Optimal Screw Choice
Authors: Okoli Michael , Chatterji Rishi , Ilyas Asif , Kirkpatrick William , Abboudi Jack , Jones Christopher M.
Published: May 2020

Background: The purpose of this study was to investigate variations in radiographic metacarpal anatomy as it relates to intramedullary (IM) fixation of metacarpal fractures and to compare this anatomy with available headless screw dimensions. Methods: We radiographically analyzed posteroanterior and lateral (LAT) radiographs of 120 metacarpals across 30 patients without structural abnormalities. Primary outcomes included IM isthmus diameter, isthmus location, metacarpal cascade, and head entry point collinear with IM canal. Measurements were compared with a list of commercially available headless screws used for IM fixation. Results: The average largest isthmus diameter was in the small metacarpal (3.4 mm), followed by the index (2.8 mm), long (2.7 mm), and ring (2.7 mm) metacarpals. The average cascade angle between long and index, long and ring, and long and small metacarpals was 0°, 24°, and 27°, respectively. The appropriate head entry point ranged between 25% and 35% from the dorsal surface of the metacarpal head on a LAT view. The retrograde isthmus location of the index and long finger was 39.2 and 38.1 mm, respectively. Twenty-five screws from 7 manufacturers were analyzed with sizes ranging from 1.7 to 4.5 mm. Only 8 of 17 screws between 2.3 and 3.5 mm had a length range above 35 mm. Conclusions: Metacarpal head entry point and cascade angle can help identify the appropriate reduction with the guide pin starting point in the dorsal 25% to 35% of the metacarpal head. Surgeons should be mindful to choose the appropriate fixation system in light of the variations between metacarpal isthmus size, isthmus location, and available screw lengths.
Joint design and torque feedback experiment of rehabilitation robot
Authors: Tang Liang , Liu Guanjun , Yang Min , Li Feiyang , Ye Fangping , Li Chenyu
Published: May 2020

The performance of the real-time dynamic force and torque compensation, flexible force interactive control, and the ability to compensate for the defect of the passive rehabilitation training are the important functions within the rehabilitation robot design process. In this investigation, the upper limb rehabilitation robot is designed, and the force sensor is used to measure the joint feedback torque with high precision, high sensitivity, and low cost. In the rehabilitation robot design process, the human–machine adaptability and lightweight flexible driving design are considered, and the static and dynamic moment detection performances of the driving joint are analyzed. Furthermore, the impedance control algorithm is used to control the force output of the single drive joint, and then the sinusoidal force output performance and step force output performance are tested under different amplitudes and frequencies. Finally, the passive rehabilitation mode of the prototype is tested to evaluate the performance of the rehabilitation robot. The results show that the force output accuracy and stability of the driving joint has a good performance, which can satisfy the force-assisted application of exoskeleton.
Structural and tribological properties of tungsten oxide thin film on a silicon substrate
Authors: Ziakhodadadian Siamak , Ren Tianhui
Published: May 2020

In this work, tungsten oxide thin films are deposited on silicon substrates using the hot filament chemical vapor deposition system. The influence of substrate temperature on the structural, morphological, and elemental composition of the tungsten oxide thin films is investigated using X-ray diffraction, field-emission scanning electron microscopy, and X-ray photoelectron spectroscopy techniques. Also, the mechanical and tribological properties of these thin films are considered using nanoindentation and scratch tests. Based on X-ray diffraction results, it can be concluded that tungsten oxide thin films are synthesized with a cubic WO3 structure. From field-emission scanning electron microscopy images, it can be seen that tungsten oxide thin films are made of crystal clusters which have grown vertically on the substrate surface. In addition, the results exhibit two asymmetric W4d5/2 and W4d7/2 peaks which can be assigned to W5+ and W4+ species, respectively. The mechanical results show that the hardness and the elastic modulus increase on raising the substrate temperature up to 600 °C. From the tribological performances, the friction coefficient of the tungsten oxide thin film decreases on increasing the substrate temperature.
Mesothelin expression in esophageal adenocarcinoma and squamous cell carcinoma and its possible impact on future treatment strategies
Authors: Moentenich Valeska , Comut Erdem , Gebauer Florian , Tuchscherer Armin , Bruns Christiane , Schroeder Wolfgang , Buettner Reinhard , Alakus Hakan , Loeser Heike , Zander Thomas , Quaas Alexander
Published: May 2020

Background:

Mesothelin is expressed at very low levels by normal mesothelial cells but is overexpressed in several human cancers. This makes mesothelin a promising target for immunotherapy. Limited data exist about mesothelin expression in esophageal carcinoma. In a current clinical trial, the highly potent anti-mesothelin antibody anetumab ravtansine is used in patients with mesothelin-positive tumors. Response rates are correlated with mesothelin expression (using the Ventana antibody) in tumor cells. No data are available on expression levels using the Ventana antibody. Most data have been generated using the Novocastra antibody. As patients are selected for clinical trials based on antibody staining of tumor samples, a comparison of these two available antibodies is crucial.

Methods:

We analyzed 481 esophageal carcinomas [373 esophageal adenocarcinomas (EACs), 108 esophageal squamous cell carcinomas (ESCCs)] using two different monoclonal antibodies (Novocastra and Ventana) for mesothelin expression (low–mid and high-level expression, as used in one clinical trial). We also checked for the correlation of these results with clinical and molecular data.

Results:

We revealed different staining results for both antibodies in EACs: Ventana: 53.6% (low expression: 25.3%; high expression: 28.3%) and Novocastra: 35.7% (low expression: 21.2%; high expression 14.5%). In ESCC we found comparable staining results: Ventana: 13.3% (low expression: 9.5%; high expression: 3.8%) and Novocastra: 13% (low expression: 11.1%; high expression: 1.9%). ARID1a-deficient EAC patients demonstrated significantly higher rates of mesothelin-positive tumors than ARID1a intact EAC patients. No correlations were found with other molecular alterations ( TP53 mutation, ERBB2 amplification) or survival rates.

Conclusion:

To the best of our knowledge, this is the largest study analyzing the importance of mesothelin expression in esophageal carcinoma. This study revealed a significant number of mesothelin-positive esophageal carcinomas, especially adenocarcinomas. New therapeutic targets are urgently required to improve the outcome of patients with locally advanced or metastasized esophageal carcinoma. The inhibition of mesothelin can be a new attractive target.
Improved efficiency of patient admission with electronic health records in neurosurgery
Authors: Polanski Witold H , Danker Adrian , Zolal Amir , Senf-Mothes David , Schackert Gabriele , Krex Dietmar
Published: May 2020

Background:

Electronic health records (EHRs) may be controversial but they have the potential to improve patient care. We investigated whether the introduction of an electronic template-based admission form for the collection of information about the patient’s medical history and neurological and clinical state at admission in the neurosurgical unit might have an impact on the quality of documentation in a discharge record and the amount of time taken to produce this documentation.

Method:

A new digital template-based admission form (EHR) was developed and assessed with QNOTE, an assessment tool of medical notes with standardised criteria and the possibility to benchmark the quality of documentations. This was compared to 30 prior paper-based handwritten documentations (HWD) regarding the utilisation of these medical notes for dictation of medical discharge records.

Results:

Implementation of the EHR significantly improved the quality of patient admission documentation with a QNOTE mean grand score of 87 ± 22 ( p < 0.0001) compared to prior HWD with 44 ± 30. The mean documentation time for HWD was 8.1 min ± 4.1 min and the dictation time for discharge records was 10.6 min ± 3.5 min. After implementation of EHR, the documentation time increased slightly to 9.6 min ± 2.3 min (n.s.), while the time for dictation of discharge records was reduced to 5.1 min ± 1.2 min ( p < 0.0001). There was a clear correlation between a higher quality of documentation and a higher needed documentation time as well as higher quality of documentation and lower dictation times of discharge records.

Conclusion:

Implementation of the EHR improved the quality of patient admission documentation and reduced the dictation time of discharge records.

Implications:

It is crucial to involve stakeholders and users of EHRs in a timely manner during the stage of development and implementation phase to ensure optimal results and better usability.
Postoperative admission to paediatric intensive care after tonsillectomy
Authors: Levi Eric , Alvo Andrés , Anderson Brian J , Mahadevan Murali
Published: May 2020

Objectives:

To review interventions required by children admitted for intensive care management following tonsillectomy or adenotonsillectomy either as elective or unplanned admission in a tertiary children’s hospital.

Methods:

A retrospective chart review over a 10-year period between April 2007 and March 2017 was performed. Charts were interrogated for treatments that were administered in the paediatric intensive care unit. Respiratory support therapies such as supplemental oxygen administration, high-flow nasal oxygen, positive pressure ventilation, continuous positive airway pressure, airway interventions and tracheal intubation were reviewed.

Results:

There were 103 children admitted to the paediatric intensive care unit following tonsillectomy or adenotonsillectomy. The average age was 6.2 years (range 7 months–17 years). The main indications for the procedure were sleep disordered breathing or obstructive sleep apnoea syndrome. In all, 53 children had syndromes with medical comorbidities, 31 were current continuous positive airway pressure users and 5 had a tracheostomy in situ. Forty children admitted to paediatric intensive care unit did not require any high-level care. Ten children who had an unplanned admission had their respiratory interventions started in the theatre or in the post-anaesthetic care unit, before paediatric intensive care unit admission, and did not require escalation of care.

Conclusion:

Children may not require admission for intensive care after tonsillectomy if they have had an incident-free period in the post-anaesthetic care unit. Some of those who required high-flow nasal oxygen could have been managed on the ward provided with adequate training and monitoring facilities. The level of care they require in post-anaesthetic care unit reflected the level of care for the immediate postoperative period in the paediatric intensive care unit.
Comparative analysis of the access to health-care services and breast cancer therapy in 10 Eastern European countries
Authors: Dimitrova Maria , Lakic Dragana , Petrova Guenka , Bešlija Semir , Culig Josip
Published: May 2020

Aim:

The aim of this study is to compare the differences in breast cancer therapy, health-care service practices, and their availability in ten European countries—Albania, Bosnia and Herzegovina, Bulgaria, Kosovo, Montenegro, Republic of North Macedonia, Croatia, Romania, Slovenia, and Republic of Serbia.

Methods:

An inquire survey was conducted among oncologists in the participating countries. The questionnaire was of qualitative character and focused on several key areas as screening practices, diagnosing, treatment, and health-care procedures utilization. The results were processed through comparative and percentage analysis.

Results:

All of the observed countries have national registries for breast cancer, but only in five, a mechanism of controlled action of early detection is implemented. Ninety percent of the countries have implemented in the national guidelines the European Society of Medical Oncology recommendations, while National Comprehensive Cancer Network is considered in only 50%. In all countries, digital mammography is a universal diagnostic method. Pathohistological analysis, including HER2 receptor expression and determination of the level of progesterone and estrogen receptors, is routinely performed in all countries prior to therapy. Some differences are observed in terms of FISH/CISH methods, determination of Ki-67 volume, and prognostic molecular assays. Trastuzumab is used as neo-adjuvant therapy in HER2-positive disease in all countries, while in Bosnia and Herzegovina and Croatia, only pertuzumab is used. Psychological support is integrated into the professional guidelines for treatment and monitoring in Bosnia and Herzegovina, Bulgaria, and Serbia.

Conclusions:

The international guidelines should be followed strictly, and some improvements in the health policies should be made in order to decrease the differences and inequalities in the availability of the breast cancer (BC) health services in the Central and Eastern European countries.
Rapid decline in ejection fraction and persistent elevation of troponin associated with cardiac amyloidosis
Authors: Abe Temidayo , Chang Eric Y , De Allie Gabrielle , Ajose Taiwo , Nwokike Chukwuemeka , Bakinde Nicolas
Published: May 2020

Cardiac amyloidosis is an increasingly recognized cause of heart failure. It remains underdiagnosed despite a significant morbidity and mortality rate. The mean survival in patients with cardiac amyloidosis is less than 1 year in untreated primary light-chain amyloidosis and less than 4 years in wild-type transthyretin amyloidosis. We report a unique case of a 78-year-old male with transthyretin cardiac amyloidosis, who presented with persistently elevated troponin and progressive heart failure unresponsive to conventional therapy. With this case, we would like to highlight the role of cardiac biomarkers in the early diagnosis of cardiac amyloidosis.
Building Social Media Observatories for Monitoring Online Opinion Dynamics
Authors: Willaert Tom , Van Eecke Paul , Beuls Katrien , Steels Luc
Published: May 2020

Social media house a trove of relevant information for the study of online opinion dynamics. However, harvesting and analyzing the sheer overload of data that is produced by these media poses immense challenges to journalists, researchers, activists, policy makers, and concerned citizens. To mitigate this situation, this article discusses the creation of (social) media observatories: platforms that enable users to capture the complexities of social behavior, in particular the alignment and misalignment of opinions, through computational analyses of digital media data. The article positions the concept of “observatories” for social media monitoring among ongoing methodological developments in the computational social sciences and humanities and proceeds to discuss the technological innovations and design choices behind social media observatories currently under development for the study of opinions related to cultural and societal issues in European spaces. Notable attention is devoted to the construction of Penelope: an open, web-services-based infrastructure that allows different user groups to consult and contribute digital tools and observatories that suit their analytical needs. The potential and the limitations of this approach are discussed on the basis of a climate change opinion observatory that implements text analysis tools to study opinion dynamics concerning themes such as global warming. Throughout, the article explicitly acknowledges and addresses potential risks of the machine-guided and human-incentivized study of opinion dynamics. Concluding remarks are devoted to a synthesis of the ethical and epistemological implications of the exercise of positioning observatories in contemporary information spaces and to an examination of future pathways for the development of social media observatories.
The Psychometric Properties of the Turkish Version of the Trait Emotional Intelligence Questionnaire–Child Form
Authors: Beyazit Utku , Yurdakul Yeşim , Ayhan Aynur Bütün
Published: May 2020

The aim of this study was to adapt the Trait Emotional Intelligence Questionnaire–Child Form (TEIQue-CF) into Turkish and to examine the psychometric properties of the Turkish version of the form. The participants of the study consisted of 208 children between the ages of 8 and 12 who were recruited from a primary and a secondary school in Antalya, Turkey. In terms of validity, construct and criterion-related validity analyses were conducted. The confirmatory factor analysis revealed a construct of nine facets and two factors. In terms of the criterion-related validity, significant correlations ( p < .01) were found between the scores of the Index of Empathy for Children and Adolescents (IECA) and the Socioemotionality, Emotion Control, and total scores of TEIQue-CF. For the examination of the reliability, the internal consistency coefficients were computed. Cronbach’s alpha coefficient for the total questionnaire was found to be .91. According to the results, this study provides an instrument that can be used for assessing the trait emotional intelligence of children in a Turkish sample.
Development and Validation of a Patient Version of Person-Centered Critical Care Nursing Questionnaire: A Methodological Study
Authors: Hong Jiwon , Kang Jiyeon
Published: May 2020

This study aimed to develop a questionnaire to evaluate person-centered critical care nursing from a patient perspective (PCCNPq). We created a 26-item preliminary questionnaire based on a literature review and qualitative interviews and administered it to 411 patients who had experienced critical care. We assessed the questionnaire’s reliability and validity using exploratory factor analysis and confirmatory factor analysis and tested internal consistency and test–retest reliability. The final version of the PCCNPq comprised five factors: compassion, expertise, communication, comfort, and respect. The model fit was satisfactory, and the items demonstrated good convergent and discriminant validity. In conclusion, the 20-item PCCNPq has acceptable reliability and validity and is applicable for assessing person-centered critical care nursing from a patient perspective.
The Employee Attributions of Corporate Hypocrisy in Corporate Social Responsibility: An Explore Research Based on Grounded Theory
Authors: Zhao Hongdan , Xu Jing , Chen Yuanhua , Sun Wenyuan
Published: May 2020

From a global perspective, the hypocrisy of enterprises in fulfilling their social responsibilities has become a common phenomenon. However, theoretical research on corporate hypocrisy, especially in the micro level, is still insufficient. To enrich the theoretical achievements of corporate hypocrisy in the micro level, this study adopted the grounded theory methods to explore the employee attributions of corporate hypocrisy in Corporate Social Responsibility (CSR) and dig deeper into the internal links and role paths between the attributions. After the process of defining problems, collecting data, three-level coding, construction theory, and saturation test, we used dates from 21 employees and found that the employee attributions of corporate hypocrisy consist of six major categories: capacity limitation, external pressure promotion, lack of supervision, sincerity of keeping promises, speculation, and external tolerance. Besides, this study proposed a mechanistic model of the employee attributions of corporate hypocrisy in CSR and pointed out that the degree of external tolerance, the sincerity of keeping promises, and speculation play moderating roles in the main effect. Moreover, the speculation also plays a mediating role in the moderation effect of external tolerance’ moderation.
Postoperative lymphocyte percentage and neutrophil–lymphocyte ratio are useful markers for the early prediction of surgical site infection in spinal decompression surgery
Authors: Inose Hiroyuki , Kobayashi Yutaka , Yuasa Masato , Hirai Takashi , Yoshii Toshitaka , Okawa Atsushi
Published: May 2020

Purpose:

Although the neutrophil–lymphocyte ratio (NLR) is a simple biomarker for inflammation, its diagnostic value for predicting surgical site infection (SSI) after spinal decompression surgery has not been extensively investigated. We aimed to determine the predictive value of NLR for SSI in patients undergoing spinal decompression surgery.

Methods:

We performed a retrospective observational study of patients who underwent spinal decompression surgery. Consecutive 254 patients were divided into an SSI group and a non-SSI group based on the presence of SSI. We evaluated which markers, including NLR, differed significantly between groups. We then determined the diagnostic cutoff values of these markers for the prediction of SSI based on the significance in the univariate analysis.

Results:

The incidence of SSI was 7 of 254 patients (2.8%). Univariate analysis showed that there were significant differences in the C-reactive protein (CRP) level at 1 day postoperatively; neutrophil and lymphocyte percentage and NLR at 3–4 days postoperatively; and CRP level, white blood cell count, neutrophil count and percentage, lymphocyte percentage, and NLR at 6–7 days postoperatively between SSI and non-SSI groups. Among these markers, the cutoff values of lymphocyte percentage and NLR at 3–4 days postoperatively for the prediction of SSI were ≤15.1% and ≥4.91, respectively. The cutoff values of lymphocyte percentage and NLR at 6–7 days postoperatively were ≤19.8% and ≥3.21, respectively.

Conclusions:

Lymphocyte percentage and NLR at 3–4 and 6–7 days postoperatively were useful markers for the early prediction of SSI in patients who had undergone spinal decompression surgery. These parameters may aid in identifying patients at higher risk of SSI after spinal decompression surgery.
Multiple needle puncture combined with repetitive knee manipulation in total knee arthroplasty for correcting varus deformity
Authors: Yuenyongviwat Varah , Iamthanaporn Khanin , Tuntarattanapong Pakjai , Dissaneewate Kantapon , Tangjatsakow Preyanun , Liawrungrueang Wongthawat , Hongnaparak Theerawit
Published: May 2020

Purpose:

Multiple needle punctures (MNPs), for gap balancing in total knee replacement, have less variability in gap widening compared to the conventional released technique. This study aimed to evaluate the outcome of gap-balancing techniques in varus osteoarthritis (OA) knees, by serial MNP, after a total knee prosthesis trial component was placed, combined with repetitive knee manipulation.

Methods:

This study was a retrospective, case-matched study of 161 patients. The data were collected from varus OA knee patients, who had total knee arthroplasty by a single surgeon. Sixty-eight patients required MNP, combined with repetitive knee manipulation for gap balancing, and 93 patients did not. Both groups of MNP patients underwent the same surgical technique and postoperative care protocols.

Results:

Knee society scores, in terms of knee score and functional score, were not different in both groups when we started the study, at 6-month and 1-year follow-ups ( p > 0.05). The femorotibial angle was not significantly different between groups at the start of the study, initial postoperative, 6 months, and 1 year ( p = 0.74, 0.45, 0.99, and 0.82, respectively). Medial joint opening in knee radiographic was found in 3% of the patients in the MNP group and in 4% of patients in the control group at 1-year follow-up ( p = 0.65).

Conclusion:

This study found MNP combined with repetitive knee manipulation was effective, reproductive, and a safe method for varus OA knee. We believe that the cycle of performed needle punctures, knee manipulation, and reevaluation could gradually lengthen the medial soft tissue without risk of over lengthening or medial collateral ligament rupture.
Meta-analyses in management: What can we learn from clinical research?
Authors: Sartal Antonio , González-Loureiro Miguel , Vázquez Xosé H.
Published: May 2020

We analyze the weaknesses of meta-analyses (MAs) in management research using as benchmark a scientific field where this technique shows a longer tradition: clinical research. We suggest four areas in which management research MA practices should improve: (1) availability of information and replicability of primary research, (2) correct application of statistical support, (3) execution of heterogeneity analyses, and (4) standardization of result reporting. Using a representative MA on an operations management topic, we identify qualitatively the aspects to be improved at each stage. We show the different results that could have been achieved by following standard procedures in clinical research, incorporating different “good practices” from this research field. Overall, these recommendations aim at improving the transparency and replicability of MAs, which can not only facilitate the accumulation of scientific knowledge but also intensify the dialogue between academia and practitioners.

JEL CLASSIFICATION: C01; M11; M1
Secondary leukemia in patients with germline transcription factor mutations (RUNX1, GATA2, CEBPA)
Authors: Brown Anna L. , Hahn Christopher N. , Scott Hamish S.
Published: May 2020

Recognition that germline mutations can predispose individuals to blood cancers, often presenting as secondary leukemias, has largely been driven in the last 20 years by studies of families with inherited mutations in the myeloid transcription factors (TFs) RUNX1, GATA2, and CEBPA. As a result, in 2016, classification of myeloid neoplasms with germline predisposition for each of these and other genes was added to the World Health Organization guidelines. The incidence of germline mutation carriers in the general population or in various clinically presenting patient groups remains poorly defined for reasons including that somatic mutations in these genes are common in blood cancers, and our ability to distinguish germline (inherited or de novo) and somatic mutations is often limited by the laboratory analyses. Knowledge of the regulation of these TFs and their mutant alleles, their interaction with other genes and proteins and the environment, and how these alter the clinical presentation of patients and their leukemias is also incomplete. Outstanding questions that remain for patients with these germline mutations or their treating clinicians include: What is the natural course of the disease? What other symptoms may I develop and when? Can you predict them? Can I prevent them? and What is the best treatment? The resolution of many of the remaining clinical and biological questions and effective evidence-based treatment of patients with these inherited mutations will depend on worldwide partnerships among patients, clinicians, diagnosticians, and researchers to aggregate sufficient longitudinal clinical and laboratory data and integrate these data with model systems.
Genetics of progression from MDS to secondary leukemia
Authors: Menssen Andrew J. , Walter Matthew J.
Published: May 2020

Our understanding of the genetics of acute myeloid leukemia (AML) development from myelodysplastic syndrome (MDS) has advanced significantly as a result of next-generation sequencing technology. Although differences in cell biology and maturation exist between MDS and AML secondary to MDS, these 2 diseases are genetically related. MDS and secondary AML cells harbor mutations in many of the same genes and functional categories, including chromatin modification, DNA methylation, RNA splicing, cohesin complex, transcription factors, cell signaling, and DNA damage, confirming that they are a disease continuum. Differences in the frequency of mutated genes in MDS and secondary AML indicate that the order of mutation acquisition is not random during progression. In almost every case, disease progression is associated with clonal evolution, typically defined by the expansion or emergence of a subclone with a unique set of mutations. Monitoring tumor burden and clonal evolution using sequencing provides advantages over using the blast count, which underestimates tumor burden, and could allow for early detection of disease progression prior to clinical deterioration. In this review, we outline advances in the study of MDS to secondary AML progression, with a focus on the genetics of progression, and discuss the advantages of incorporating molecular genetic data in the diagnosis, classification, and monitoring of MDS to secondary AML progression. Because sequencing is becoming routine in the clinic, ongoing research is needed to define the optimal assay to use in different clinical situations and how the data can be used to improve outcomes for patients with MDS and secondary AML.