bluuebunny/crossref_metadata_2025 huggingface dataset:
Machine learning-guided high throughput nanoparticle design
Authors: Ortiz-Perez Ana , van Tilborg Derek , van der Meel Roy , Grisoni Francesca , Albertazzi Lorenzo
Published: August 2023

Designing nanoparticles with desired properties is a challenging endeavor, due to the large combinatorial space and complex structure-function relationships. High throughput methodologies and machine learning approaches are attractive and emergent strategies to accelerate nanoparticle composition design. To date, how to combine nanoparticle formulation, screening, and computational decision-making into a single effective workflow is underexplored. In this study, we showcase the integration of three key technologies, namely microfluidic-based formulation, high content imaging, and active machine learning. As a case study, we apply our approach for designing PLGA-PEG nanoparticles with high uptake in human breast cancer cells. Starting from a small set of nanoparticles for model training, our approach led to an increase in uptake from ~5-fold to ~15-fold in only two machine learning guided iterations, taking one week each. To the best of our knowledge, this is the first time that these three technologies have been successfully integrated to optimize a biological response through nanoparticle composition. Our results underscore the potential of the proposed platform for rapid and unbiased nanoparticle optimization.
Molecular Driving Forces in the Self-Association of Silaffin Peptide R5 from MD Simulations
Authors: Mao Coco , Sampath Janani , Pfaendtner Jim
Published: August 2023

The 19-residue silaffin-R5 peptide has been widely studied for its ability to precipitate uniform SiO2 particles through mild temperature and pH pathways, in the absence of any organic solvents. There is consensus that post-translational modification (PTM) of side chains has a large impact on the biomineralization process. Thus, it is imperative to understand the precise mechanisms that dictate the formation of SiO2 from R5 peptide, including the effects of PTM on peptide aggregation and peptide-surface adsorption. In this work, we use molecular dynamics (MD) simulations to study the aggregation of R5 dimer with multiple PTMs, with the presence of different ions in solution. Since this system has strong interactions with deep metastable states, we use parallel bias metadynamics with partitioned families to efficiently sample the different states of the system. We find that peptide aggregation is a prerequisite for biomineralization. We observe that the electrostatic interactions are essential in the R5 dimer aggregation; for wild type R5 that only has positively charged residues, phosphate ions HPO42- in the solution form a bridge between two peptides and are essential for peptide aggregation. Alternatively, the post translational modification phosphorylation, which renders neutral serine residues negative, enables R5 to aggregate without phosphate ion. The extent of phosphorylation and location of phosphorylated residues on R5 peptide results in different behavior and extent of aggregation - the aggregation trend of R5 peptide that we observe is in line with SiO2 precipitation observed in previous experimental studies, proving that peptide aggregation is a prerequisite for biomineralization.
Comparison of Coronavirus Anxiety, Sleep Quality and Quality of Life in Pregnant Women with Healthy Controls
Authors: BAŞAR KOCAGÖZ Zehra , SARIGEDİK Enes , SARIGEDİK Burcu
Published: August 2023

Objective: In the pandemic, pregnant women are at the forefront of the disadvantaged groups and need special needs related to more mental problems. This study aims to evaluate the pandemic anxiety of pregnant women and how their sleep and quality of life are affected.

Materials and Methods: 200 pregnant and 200 control patients were included in the study. Informed consent was obtained from the participants. They were asked to fill out the sociodemographic data form, The Coronavirus Anxiety Scale (CAS), the Pittsburgh sleep quality index (PSQI), and the 12-Item Short Form Survey (SF-12) Quality of Life scale.

Results: No statistically significant difference was found in the CAS between pregnant and healthy controls (p=0.093). While the physical score subscale of the SF-12 Quality of Life Scale (SF12-PCS) scored statistically significantly higher in pregnant women compared to the healthy controls, the mental score subscale (SF12-MCS) scored significantly lower (respectively: p
The Relationship between Tolerance, Forgiveness, and Depression Levels in Patients Diagnosed with Depression
Authors: MERSİN Sevinç , UYAR Sezai
Published: August 2023

Objective: This study aimed to determine the relationship between the level of tolerance, forgiveness, and depression in patients diagnosed with depression.

Materials and Methods: It was conducted with 80 patients in the outpatient psychiatry clinic of a hospital in Turkey. Data was collected with Beck Depression Inventory, Tolerance Scale and Heartland Forgiveness Scale. Data were evaluated using SPSS (21.0) statistical program.

Results: In this study, while it was determined that there was a statistically significant negative and moderately relationship between the mean Beck Depression Inventory and Tolerance Scale scores, a weak negative relationship was found between the mean Beck Depression Inventory and Heartland Forgiveness Scale scores. Also, it was determined that tolerance and forgiveness predicted depression negatively.

Conclusion: The results of this study can be used for interventions that include tolerance and forgiveness in reducing depression.
Evaluation of Thyroid Dysfunction in Patients with Atrial Fibrillation
Authors: VARIM Perihan , DEMİRCİ Taner
Published: August 2023

Objective: Atrial fibrillation is a common cardiac arrhythmia and is an important risk factor for ischemic stroke and heart failure. Thyroid hormones have important effects on the cardiovascular system. In this study, we aimed to evaluate the relationship between atrial fibrillation (AF) and thyroid disorders.

Materials and Methods: 587 newly diagnosed AF patients who applied to the Cardiology Clinic between January and December 2022 were included in this study. Thyroid function tests of the patients were examined.

Results: The mean age of the patients included in the study was 62.2 ± 9.8 years. 62% of the patients were female, and 38% were male. Euthyroid in 539 patients (91.7%), hypothyroidism in 2 patients (0.3%), subclinical hypothyroidism in 11 patients (2%), hyperthyroidism in 23 patients (3.9%), and subclinical hyperthyroidism in 12 patients (2.1%).

Conclusion: Atrial Fibrillation is associated with both hyperthyroidism and hypothyroidism. Thyroid dysfunctions are more common in patients with AF than in the normal population. Patients with AF should be screened for thyroid disorders.
THE RELATIONSHIP BETWEEN CORPORATE SOCIAL RESPONSIBILITY AND MARKET SHARE: EVIDENCE FROM NIGERIA IN WEST AFRICA
Authors: Adekanmi Aderemi Daniel , Ololade Babatunde Moses , Adeoye Ebunoluwa Tokunbo
Published: August 2023

The study examined the effect of corporate social responsibility on market share of listed manufacturing firm in Nigeria. It specifically examined the effect of internal environmental cost on market share of listed manufacturing firms in Nigeria, it also examined the effect of external environmental cost on market share of listed manufacturing firms in Nigeria. The study predicated of stakeholder’s theory.
The study adopted Ex post facto research design and secondary data was gathered to analyse the relationship between the variables. The population of the study consisted of forty-two manufacturing listed in the Nigeria Stock Exchange, while ten samples were collected from the population. The data collected were analysed through descriptive statistic, Error Correction MODEL (Long and short run relationship), and correlation matrix regression analysis.
The result of the findings revealed that internal environmental cost has positive and significant effect on market share of listed manufacturing firms in Nigeria (p= 0.1.454 > 0.05) and external environmental cost has positive and significant effect on market share of listed manufacturing firms in Nigeria(p=0.6757 > 0.05)
The study concluded that CSR activities such as internal environmental cost and external environmental cost through donations to the society where they operate their business and other social and infrastructural facilities reflect in their annual financial statement as external cost incurred during the year.
The study recommended that Nigerian manufacturing firms take advantage of external environmental costs by investing more on the business's environment, notably via corporate social responsibility 
Key: Corporate Social Responsibility, Internal Environmental Cost, External Environmental Cost, Market Share
Risk Aversion and Self Insurance Utilisation: Evidence from Small and Medium Scale Business Owners in Lagos State
Authors: ABASS Olufemi Adebowale
Published: August 2023

This study is to examined the influence of risk aversion on the adoption and utilisation of self-insurance among Small Medium Enterprises (SME) owners in Lagos State. This study employed cross sectional class of survey research design. Three hundred and fifty SME owners were selected using Taro Yamane formula and the data obtained was analyzed using correlation and t-test inferential statistics. Questionnaires were administered through convenience sampling method. The result of the study revealed a significant relationship between risk aversion and self-insurance utilisation among SME owners in Lagos State. Additionally, the result of this study also revealed that there is no significant difference between preference for conventional insurance and self-insurance among Lagos State SME owners. Based on the findings of this study, it is recommended that conventional insurers should endeavour to develop products that address the actual needs of SMEs. It is also recommended that SME owners should be highly disposed to risk improvement measures as this would help to reduce the cost of market insurance and self-insurance even if both are taken up contemporaneously.
STANDARD COST EFFECT ON PERFORMANCE OF SELECTED LISTED FOOD AND BEVERAGE COMPANIES IN NIGERIA, WEST AFRICA
Authors: OLUWAYEMISI Ali-Momoh Betty , AYODEJI Adisa Lateef , OLUFEMI Ibifunmilola David , OLUWASEUN Deji-Oyeleye Bosede , KEHINDE Agbede Gabriel
Published: August 2023

The aim of this research was to determine whether or not a change in standard cost will improve the financial standing of a sample of Nigerian food and beverage manufacturers. This goal was reached by analyzing the relationship between the price of raw materials, the price of labor, and the price of manufacturing overhead on the bottom line of Nigerian food and beverage firms. Five manufacturing firms were chosen at random for the research. Nestle Plc, Cadbury Nig Plc, P.Z. Cussons Nig. Plc, and Presco Nig. Plc are the food and beverage companies that were included in the survey. In this case, we used secondary data that we had gathered over the previous decade (2010-2020). Panel estimation methods (pooled OLS, fixed effect estimation, and random effect) and a post estimation test were used to examine the compiled data. The results showed that a firm's performance in the manufacturing sector in Nigeria was significantly correlated with its manufacturing overhead costs, but negatively correlated with its raw material costs, and positively correlated with its labor costs. The research indicated that careful consideration of raw material costs and the maintenance of effective standard costing across all labor costs were necessary to obtain the desired results. Because of the significant savings in time and money that may be achieved via the use of standard costing principles and procedures, the research concludes that all food and beverage businesses in Nigeria should do so.
Annual Accounting Information and Stock Price Reactions: Evidence from Nigeria Deposit Money Banks in West Africa
Authors: OLAOYE Clement Olatunji , EKUNDAYO Temitope Ayodele , EKUNDAYO Temitope Ayodele
Published: August 2023

This paper examined the value relevance of accounting information and stock prices in Deposit Money Banks in Nigeria. Specifically, it assessed the behaviour of share prices in relation to accounting information in terms of earnings per share, book value per share, dividends per share and return on assets. The study adopted the expo-facto research design and the study elements covered all the 18 listed Deposit Money Banks; out of which, 10 Banks were selected as the study participants and this was achieved through a random sampling technique. The study covered 10 years, spanning from 2010-2019 and data were sourced from the fact book of the Nigeria Stock Exchange (NSE) and audited annual financial reports of the sampled banks. The estimation technique adopted in this study was panel data analysis technique. This was carried out after descriptive statistics and Pearson correlation. It was discovered that earnings per share, book value per share and dividends per share exert a positive and significant effect on stock prices and that return on assets exerts a positive and insignificant effect on stock prices. Based on the findings, it was established that accounting information has a positive effect on stock prices. Thus, it was recommended that timely and adequate accounting information should be made available by the management of Deposit Money Banks in Nigeria to induce the interest of investors and that investors are urged to pay more attention to earnings per share, book value per share and dividend per share in their investment decisions
Aspects of Career Management and Success in Educational Organizations
Authors: CHIRIMBU Sebastian Cristian
Published: August 2023

A modern educational institution should create the necessary conditions for the integration and development of the personal and professional competences of the teachers in order to obtain a successful career. In the current context of the educational system in the Republic of Moldova and Romania, the capitalization of human resources is a priority objective of the managers of educational institutions. The difficulties they face, the constantly changing educational reforms, the unpredictable and challenging situations are known partially or impartially theoretically and practically by teachers who are beginning to integrate into the institution, and the process of insertion from educational institutions is often not effective. We will analyse the characteristics of a successful career but also the motivation for achievement as an important component of the professionalization process, teachers thus tending to pursue challenging careers, complex enough, but not so difficult as to end in failure. Therefore, if professional motivation is an important endeavor, because it starts from the idea that a large part of everyone's life spends at work, performance denotes the achievement and ability of the teacher to respond to tasks and to be a model for those in the organization when it comes to involvement and responsibility.
Research on the Economic Effects of China's Integrated Circuit Industry from the Perspective of Input-Output
Authors: 戴 艳娟 , 李 鸿
Published: August 2023

集成电路产业在以互联网为代表的信息时代起着决定性作用,已凸显成为我国最重要的战略产业之一。本文编制了集成电路产业投入产出表,通过投入产出表的各类系数来分析我国集成电路的产业关联和波及效应。结果表明:(1)我国集成电路产业作为中间投入品与电子元器件、计算机、通信设备等制造业联系最为密切,产业整体对经济的拉动能力较强,且不易受到其他行业的影响,但集成电路材料部门对经济拉动能力明显低于其他部门,集成电路封装测试部门对经济的推动程度最高;(2)集成电路产业整体属于“出口依赖型”产业且进口依赖出口需求,分部门来看集成电路材料、制造、封装测试部门的生产和出口诱发依存特征符合产业整体趋势,集成电路设备、设计部门属于“投资依赖型”产业且进口依赖投资需求;(3)集成电路产业及其5个子部门的生产诱发系数:出口>投资,进口诱发系数的结论恰好相反。最后本文从实际角度提出增加社会资本注入、构建良好产业生态环境、加强与台湾台积电等企业的联系以及在封装测试业实现定点突破等建议;从投入产出的角度提出加强上下游协同关联、以集成电路封装测试业和制造业为产业核心、加大集成电路产业“引进来”和“走出去”对外开放力度等建议。
The Transformational Development of Socialist Foreign Trade with Chinese Characteristics and its Strategic Significance: A Review of Professor Shuli Song's “The Transformational Development of Socialist Foreign Trade with Chinese Characteristics: Based on the Empirical Study of Zhejiang's Private Economy”
Authors: 卓 勇良
Published: August 2023

中国经济在改革开放以来的增长奇迹主要源于中国外贸的持续转型发展。对中国外贸发展经验的研究发现,中国外贸出口企业所有制转型是21世纪以来外贸转型的最重要事件,尤其是民营企业以其灵活的体制机制,为中国经济稳健增长作出了积极贡献。而出口商品工业化是外贸转型的基本面,是出口快速增长的基本因素。出口市场结构也有了较大变化,从转口贸易和日本为主的狭窄出口市场,到美欧日成为重要出口目标市场,再到出口目标市场的趋于多元化。更重要的是,制度转型是关键,尤其是外贸体制改革,有效启动了中国外贸的迅猛发展。总体来看,基于外贸视角,中国改革开放进程可区分为三个阶段,分别是:改革开放至“入世”前的“序幕”,内生化改革初步形成市场主体及自主交易的体制机制;“入世”至今的“上半场”,借力境外市场形成了发展导向的改革;当下至未来相当长一段时期的“下半场”,出口遭遇天花板,形成了问题倒逼的改革,弱化乃至消除其“内生阻尼”是贯彻落实二十大精神的重要举措。
Verd – novoodkrito kolišče iz 5. tisočletja pr. Kr. na Ljubljanskem barju
Authors: Velušček Anton , Horjak Šuštaršič Mojca , Tolar Tjaša , Toškan Borut , Merela Maks , Čufar Katarina
Published: August 2023

Predstavljamo rezultate interdisciplinarnih raziskav na novoodkritem kolišču Verd na zahodnem robu Ljubljanskega barja. Za oceno starosti najdišča so bili ključni rezultati dendrokronoloških raziskav in radiokarbonskega datiranja lesa, podprtega z metodo wiggle-matching, ki posek lesa dveh pilotov z Verda postavljajo v obdobje 4674 ± 42 cal BC, kar je nekoliko starejše ali sočasno doslej najstarejšemu odkritemu kolišču Resnikov prekop pri Igu. Keramične najdbe so tipološko podobne tistim z Resnikovega prekopa. Arheozoološke raziskave ugotavljajo zastopanost izključno lovnih in odsotnost domačih živali. Arheobotanične raziskave kažejo, da je bilo naselje Verd umeščeno v dokaj naravno in vodnato okolje brez večjih vplivov človeka. Vse raziskave nakazujejo, da najdišče Verd z ostanki neolitskega kolišča iz 5. tisočletja pr. Kr., ne glede na majhnost izkopnega polja in razmeroma skromno število najdb, najverjetneje predstavlja eno najstarejših znanih koliščarskih poselitvenih točk na Ljubljanskem barju.
A Conceptual Model for Evaluating Digital Intellectual Assets
Authors: Loseva O. V. , Fedotova M. A. , Abdikeev N. M.
Published: August 2023

The object of the study is the valuation and commercialization of digital intellectual assets. The subject of the study is a conceptual model for assessing the value of digital intellectual assets, reflecting the regulatory framework, objects, subjects, principles, approaches and methods of evaluation involved in civil turnover. The relevance of the study is related to the development of the digital economy and emerging new types of digital assets, including digital intellectual assets, which require their identification and the formation of a theoretical and methodological basis for valuation. The purpose of the study is to build a conceptual model for estimating the value of digital intellectual assets for subsequent commercialization with consideration of the identified identification characteristics, substantiated principles, factors, approaches and methodological tools. The methods of comparative analysis, generalization, classification, logical, semantic and functional modeling, cost estimation are used in the paper. The trends of digitalization of the economy are analyzed, the identification features of digital intellectual assets are determined based on the study of the concepts of “digital asset”, “intellectual asset”, “object of valuation”. A semantic model of the valuation of digital intellectual assets is proposed, illustrating the relationship of its conceptual elements. A process-functional model for estimating the value of digital intellectual assets in IDEF0 notation is constructed. It is concluded that digital intellectual assets as objects of valuation in the conditions of the current regulatory regulation are: 1) the results of intellectual activity created with the use of digital technologies, for which digital rights are fixed in the information system in the form of NFT tokens; 2) digital rights to use intellectual property objects that exist in digital or other forms. Their cost can be determined by the method of analogues, the method of discounted cash flows or the cost of creation method, depending on the purpose of the assessment, the identified factors and taking into account the principles of evaluation.
Is There Any Impact of CSR on Financial Performance? Evidence from Indian Firms
Authors: Sawhney R. K. , Goel P. , Bhardwaj S. B.
Published: August 2023

The sceptical attitude towards linking corporate social responsibility (CSR) and corporate financial performance (CFP) forms the basis of this study. The available literature concentrates only on the positive side of CSR activities and benefits derived from them. The Companies Act, 2013, has made it mandatory for Indian companies of a certain turnover and profit to use 2% of their profits from the past three years on CSR activities. Given this background, this study examines the impact of CSR on the financial performance of the business itself. The economic legitimacy of CSR is also probed, that is, does CSR have a positive economic impact? For this examination, the Pearson Fixed effects panel regression analysis was performed on Nifty 50 companies during the period 2010–2018. Data regarding financial performance variables was obtained from Prowess IQ database. The CSR data was collected from the companies’ annual reports and content analysis was done using NVIVO software. The results of the study provide insights into the corporate response to the mandatory requirement of CSR activities and their impact on the company’s financial performance. The results of the study conclude that there is no significant influence of CSR on the financial performance of Indian companies.
Retirement Wealth Adequacy Estimation Based on Income Group Classification: A Case Study in Malaysia
Authors: Adnan A. A. , Alaudin R. I. , Yaakob A. M. , Ismail N.
Published: August 2023

The inadequacy of retirement wealth can significantly impact a country’s social support system. The increase of the size of the elderly population in line with the constant growth of life expectancy among Malaysians has triggered a question, are there enough resources to cover needs in retirement years? The main objective of this study is to estimate the retirement income adequacy of future retirees under a defined contribution (DC) plan, which is the Employee Provident Fund (EPF). The projection of retirement income adequacy uses cross-sectional data from the Malaysian Household Income Survey (HIS) 2014, based on 14,169 sample households. The households are categorized according to three different income groups, including Top 20% (T20), Middle 40% (M40) and Bottom 40% (B 40). In addition, this research also investigates the demographic and socio-economic determinants of retirement wealth adequacy using OLS and logistic regression. The result shows that 26% of households in the sample have inadequate retirement income, especially households in the B 40 group.
Analysis of the Share of Corporate Property Tax in the Structure of Tax Revenues by Regions and Economic Activities
Authors: Balakin R. V. , Popov A. A. , Shatalov S. D.
Published: August 2023

The subjectof the study is the revenues from the corporate property tax in the context of types of economic activity and regions.The purposeof the study is to determine the role of corporate property tax in the structure of tax revenues in terms of economic activity to identify areas for potential growth of revenues from this tax and determine the fiscal and economic consequences of the transition to the cadastral valuation of real estate with the appropriate development of proposals to improve the taxation of real estate.The relevanceof the research is due to the fact that the article is devoted to a little researched topic — analysis of property taxation in the Russian Federation in the economic activity context.The main methodof research is the calculation of indicators characterizing the structure and dynamics of the corporate property tax and other property taxes, analysis and synthesis of the obtained results and their inter-sectoral comparison.As a result, a comprehensive view of the situation with the tax on the property of organizations in the context of economic activity is presented, which serves as a basis for finding bottlenecks in this part, identifying the factors that hinder the expansion of property taxation and other promising areas for research in this area. The interpretation of the obtained results in terms of the role of corporate property tax and other property taxes at different levels of the budget system should be attributed to themain conclusions. The cross-section allowed us to identify points for the potential growth of tax revenues from the corporate property tax in terms of objects, for which the tax base is the cadastral value.
AI Language Models as Educational Allies: Enhancing Instructional Support in Higher Education
Authors: Zekaj Ramiz
Published: August 2023

Incorporating artificial intelligence (AI) to support academic faculty is the main topic of the systematic literature review. The purpose of the study is to examine the potential advantages and disadvantages of such implementation, with a particular emphasis on how the use of AI in educational settings may impact teaching methods, individualised learning experiences, and administrative procedures. For the literature review, the Science Direct, Taylor & Francis, and Emerald Insight databases were carefully examined. In order to thoroughly analyse the integration of AI in instructional faculty support, each article was evaluated for its quality of content and relevance to the research questions. According to the findings, AI-driven tools like ChatGPT and intelligent tutoring systems have the potential to significantly improve instruction and foster adaptive learning, which would result in better educational outcomes. The use of AI can enhance administrative procedures and promote personalised learning for students. By highlighting its advantages and drawbacks, this study advances knowledge of AI's function in instructional faculty support for education. By highlighting critical gaps and difficulties, this study lays the groundwork for further research and the development of best practices for AI integration in educational contexts.
Channel Effects of Korean Fund Distributors and Affiliates: Focusing on Historical Return-Chasing Phenomenon and Financial Regulations
Authors: Bae Jongwon , Song Inwook , Park Young Kyu
Published: August 2023

This study investigates the channel effects of fund distributors, specifically in terms of past return chasing, while also considering whether these fund distributors are affiliated with asset management firms or not. The empirical findings are summarized as follows. First, affiliated funds exhibit about 24% lower past return chasing compared to their non-affiliated counterparts. This result suggests that the criteria employed for selection and management of affiliate funds are notably less stringent in their reliance on past performance compared to non-affiliated funds. Second, the past return chasing behavior of affiliated funds has increased subsequent to the implementation of regulations governing fund distribution for such funds. In other words, the management of return rates for affiliate funds has become more stringent. Third, affiliate funds sold by fund distributors have higher searching costs or higher sales remuneration, particularly evident among small and low-age funds, compared to non-affiliated funds. This indicates that there is a difference in fund attributes depending on the affiliation status. This paper make a substantive contribution by providing empirical evidence on the impact of financial sales regulations, such as restrictions imposed on sales of affiliated funds.
Implementasi program literasi kesehatan dalam penanganan stunting di Desa Tambak Kalisogo
Authors: Afrizal Arrasyidin Diva , Rodiyah Isnaini
Published: August 2023

The importance of health in preventing stunting requires solutions that involve the community so that the problem of stunting becomes a shared responsibility. For this reason, the implementation of the program through health literacy is present to fix the high number of stunting cases in Tambak Kalisogo Village. This study uses a qualitative approach. Data collection techniques were carried out through direct observation at the Kalisogo pond village office. Interview technique with the village secretary. The documentation section contains village profiles. The research data analysis technique used an interactive model with four stages, namely data collection, data condensation, data presentation and drawing conclusions. Where the variables of power, interests and strategies involved in implementing the policy already involve village health cadres who are responsible for village health. The second variable is the Characteristics of the Tambak Kalisogo Village Institution consisting of 848 families, totaling 2,468 people, with details of 1,229 male residents and 1,239 female residents. The third variable is the level of compliance with the response from the program implementers of the Prosperous Child Village who are considered to be quite enthusiastic.
25-hydroxy vitamin D levels in patients with myelofibrosis and potential relationships with disease severity: A case-control study
Authors: Ipek Yildiz
Published: August 2023

Background/Aim: Although vitamin D deficiency has been associated with cancer and its prognosis, data is unclear regarding associations with myelofibrosis. This study aimed to measure 25-hydroxy vitamin D levels in patients with myelofibrosis and to evaluate its relationship with prognoses. Methods: This case-control study consisted of 72 patients with myelofibrosis and 75 controls. The Dynamic International Prognostic Scoring System was used to determine prognostic risk groups, and patients were divided into two subgroups: intermediate-1 (low risk) and intermediate-2 (high risk). Results: The median 25-OHD levels were decreased in the myelofibrosis group more so than in the controls (13.05 vs. 23.0 ng/mL, P<0.001). A cut-off value of ≤ 16.5 ng/mL yielded a sensitivity of 84.72% and a specificity of 80% for the identification of patients with myelofibrosis. This impact was also evident when adjusted for age and sex, showing that patients with low 25-hydroxy vitamin D (≤16.5) had a 23.787-fold higher probability to have myelofibrosis (OR: 23.787, 95% CI: 9.676-58.479, P<0.001). When examined for the two prognostic subgroups, 25-hydroxy vitamin D was found to be significantly lower in the intermediate-2 and high subgroup (P=0.017). For a cut-off value of ≤13.7 ng/mL, 25-hydroxy vitamin D level was able to discriminate patients in the intermediate-2 and high subgroup from those with lower risk (sensitivity: 77.8%, specificity: 55.6%). Conclusion: A serum 25-hydroxy vitamin D level may serve as a biomarker associated with myelofibrosis diagnosis and prognosis; however, the discriminatory value for prognostic groups was low, indicating the need for larger and longitudinally-designed studies.
Contemporary Issues in Collection Management
Authors: Cameron Kelsey , Chiovelli Chelsea , Deschamps Danielle , Grande-Sherbert Marty , Hakimizadeh Sadaf , Ip Andrew , Komarnytska Olesya , Nowakowsky Amy , Pei Winston , Pope Nicole , Pouliot Reis , Ramsey Melissa , Sieben Julia , Trotter Maia , Turnbull Grace , Voy Kat , Wang Dandi , Willauer Faye
Published: August 2023

This edited, openly licensed, textbook examines several different issues in collection management. Topics covered include physical vs. digital collections; the impact of BookTok on collections; challenges to 2SLGBTQ+ collections ; ebook licensing; ebook pricing; accessible collections for users with physical disabilities; accessible collections for users with invisible disabilities; "just in time"/demand-driven acquisitions; climate change and collections and research data collections.
El aula invertida como estrategia en la enseñanza híbrida: Una propuesta orientada al desarrollo del aprendizaje activo
Authors: Rodríguez Núñez José Alejandro
Published: August 2023

Tradicionalmente, los procesos de enseñanza y aprendizaje han sido desarrollados desde la teoría hacia la práctica, convertida el aula en un espacio magistral donde prevalece el método expositivo por parte del docente. En efecto, el control epistemológico se centra en el maestro, quien teoriza, conceptualiza y explica. En ese sentido, los procesos de enseñanza y aprendizaje requieren de una reinvención estratégica por parte de la planificación del docente y la acción del estudiante. Es por ello que se propone un proyecto áulico innovador, encaminado al desarrollo de estrategias en las que el discente se convierta en un ente activo y deje de ser un receptor de informaciones. En vista de lo planteado, el objetivo de este escrito es presentar el relato de la implementación del aula invertida durante la modalidad de enseñanza híbrida, con el fin de reflexionar sobre sus posibles implicaciones en el desarrollo del aprendizaje activo. Para ello se partirá de la metodología de  aprendizaje activo y el aula invertida. El enfoque metodológico empleado en esta propuesta es de carácter cualitativo, pues se pretende observar, describir y ponderar la participación del estudiantado correspondiente a una sección del curso de Español. En definitiva, los resultados de esta propuesta llevan a la innovación de un cambio activo en la docencia, exaltando dos cualidades significativas: autonomía en el estudiantado y creatividad en el profesorado. Esto se implementa sin distinción de la disciplina, grado, ciclo o nivel; lo que permite que esta sea una propuesta abierta, dinámica, integral y transversal.
Predictive Factors for Impacted Ureter Stones in Children: A Retrospective Analysis
Authors: Coşkun Burhan , Turan Levent , Bakirov Javanshir , Günseren Kadir Ömür , Kaygısız Onur
Published: August 2023

Objective: This study aimed to ascertain predictive indicators for the occurrence of impacted ureteral calculi in pediatric patients. Methods: A retrospective investigation of 68 pediatric cases that underwent ureteroscopy (URS) for
ureteral calculi between March 2012 and July 2022 was undertaken. Within this cohort, 19 patients were diagnosed with impacted calculi. Non-contrast thin-section abdominal computed tomography (NCCT) scans were utilized to assess
stone dimensions, density, the incidence of hydronephrosis, and calculi positioning. The cohort was segregated into two groups: Group 1, comprising patients with impacted stones, and Group 2, those without. A statistical evaluation
was performed to identify the significant predictors of calculi impaction. Results: In the impacted stone cohort, a higher mean calculi diameter was noted (p=0.053). A higher incidence of calculi impaction was observed in the proximal
ureter, and a positive correlation was found between the severity of hydronephrosis and the detection of impacted calculi. For proximal ureteral stones, a diameter exceeding 8.5mm demonstrated increased propensity for impaction.
Logistic regression analysis revealed that the occurrence of calculi in the proximal ureter was associated with a 3.195-fold increased risk of impaction compared to the distal ureter, while severe hydronephrosis corresponded with
a 39-fold elevated likelihood of calculi impaction compared to low-grade or absent hydronephrosis. Conclusion: In pediatric patients with proximal ureteral stones, severe hydronephrosis and stone diameters surpassing 8.5mm were
indicative of calculi impaction, thereby advocating endoscopic stone surgery as the primary therapeutic intervention.
The Politics and Economics of Brazilian Competition Law
Authors: Kira Beatriz
Published: August 2023

Against the renewed international debate on the relationship between competition law and wider social and economic goals, this paper examines the underpinnings of Brazilian competition law. It describes the evolution of the law against the backdrop of the wider transformations in capitalism, and reveals how legal, political, and economic disputes – both domestically and internationally – have shaped its design and implementation. The paper argues that while the foundation of modern Brazilian competition law can be found in a progressive Constitution and in principles that guide the economic order towards the promotion of substantive justice, competition enforcement and scholarship in Brazil have been gradually decoupled from the promotion of socioeconomic rights. This insulation of Brazilian competition practice from wider socio-political concerns was deeply influenced by the epistemological assumptions and the economic methodology of the Chicago School, that have directed competition – in the US and in other jurisdictions – towards formalist notions of efficiency.
El derecho de la competencia de la Comunidad Andina frente a la sostenibilidad ambiental
Authors: Kahl Sonja , Luyo Castañeda Michael
Published: August 2023

This article aims at sparking a debate on how Andean competition law could be improved in order to contribute to environmental protection. Although regional competition law is currently distant from environmental issues, the discipline may well play a key role in protecting the environment in the countries that make up the Andean Community. Indeed, on the one hand, competition law can incentivize certain corporate behavior that is beneficial to environmental sustainability; and, on the other hand, it can prevent and sanction business activities that have harmful effects on the environment. This article points out several mechanisms that could enable this “greening” of competition law.
Keragaman dan Prediksi Kehilangan Hasil Kedelai (Glycine max L. Merrill.) Akibat Kompetisi Gulma Teki dan Rumput-rumputan di Lahan Kering
Authors: I Ketut Ngawit  , A. Farid Hemon  , Herni Hariani
Published: August 2023

Penelitian bertujuan untuk mengetahui keanekaragaman gulma teki dan rumput-rumputan serta spesies yang paling berpengaruh menurunkan hasil tanaman kedelai di lahan kering. Metode penelitian yang digunakan adalah deskriptif dengan teknik survey. Penentuan petak sampel dilakukan secara sistematik random sampling. Petak-petak sampel diletakkan pada 5 titik yang berbeda dengan ukuran 1 m x 1 m. Spesies gulma yang ditemukan pada setiap petak sampel populasinya dihitung dan masing-masing spesies didokumentasikan untuk proses identifikasi. Hasil penelitian menunjukkan bahwa ditemukan sebanyak 2 spesies gulma teki yaitu Cyperus rotondus L., dan Cyperus iria L. dan10 spesies gulma rumput-rumputan pada saat kedelai berumur 20 - 50 HST. Tujuh spesies dominan dengan nilai SDR selama tumbuh tanaman ≥ 6% - ≤ 12% dan tiga spesies gulma rumput-rumputan yaitu Brachiaria reptans L. Gardner., Axonopus compressus (Swartz.) dan Echinochloa colonum L. Link. ditemukan tidak dominan dengan nilai SDR kurang dari 1%. Daya saing dan dominansi terbobot gulma Leersia hexandra L. Sw., Cyperus Rotondus L., Digitaria spp., Paspalum vaginatum  L. Sw., Cynodon dactylon L., Cyperus iria L. dan Eleusine indica Gaertn., lebih besar dibandingkan dengan spesies gulma lainnya, sehingga mampu menghilangkan hasil bobot kering kedelai selama tumbuh tanaman sebanyak 2-5%. Ketujuh spesies gulma ini, harus dikendalikan sejak awal pertumbuhan kedelai, karena mampu mendominansi areal pertanaman dengan keragaman, penyebaran dan kelimpahan yang tinggi. Gulma Brachiaria reptans L. Gardner., Axonopus compressus (Swartz.) dan Echinochloa colonum L. Link., keberadaannya pada tanaman kedelai menyebabkan kehilngan hasil tanaman kedelai sangat rendah, yaitu kurang dari 1%.
MOBILIDADE E ACESSIBILIDADE DE PESSOAS COM DEFICIÊNCIA VISUAL: UM PARALELO ENTRE AS INSTITUIÇÕES "ACIDE" E UESB
Authors: Araújo Maria Luiza Barbosa
Published: August 2023

A presente pesquisa de campo foi realizada na Associação Conquistense de Integração do Deficiente (ACIDE), instituição sem fins lucrativos fundada em 1989. Este trabalho propõe a análise dos aspectos
New Onset Seizures in a Child Taking 0.01% Atropine Drops
Authors: Caitlyn Mulcahey , Steve Gerber
Published: August 2023

Introduction: Myopia is a refractive disorder commonly diagnosed in childhood that follows a progressive course. It is considered a global epidemic with nearly 23% of the world’s population being diagnosed with this condition. Moreover, myopia is increasing in prevalence worldwide, demonstrated by studies in Asian and Western populations. This has important implications as myopic progression to high myopia is associated with significant morbidity and visual disability if left untreated. Of these treatments, the pharmacologic agent atropine has demonstrated the greatest efficacy in reducing myopia progression. Case report: This is a case report of an 11-year-old male treated with 0.01% atropine drops for myopia progression that developed new-onset seizures. The seizures were characterized as benign epilepsy with central temporal spikes and ceased when drops were discontinued. Discussion: Atropine 1% drops have previously been associated with new or increased seizure activity in a handful of case reports, however, it is our knowledge that this is the first report associated with 0.01% drops. This is important given the growing use of 0.01% drops as well as higher concentrations such as 0.025 % and 0.05% for the treatment of pediatric myopia. Conclusion: While it cannot be proven that the drops were causative in the seizure events, it is important to consider prior seizures as a relative contraindication to the use of these drops. Atropine has the potential to exacerbate seizure activity, so it is possible that the 0.01% atropine drops played a role in the patient’s seizures. Also, any diagnosis of new-onset seizures in pediatric patients should prompt discontinuation of drops at seizure onset.
High Magnification in Dentistry; Postural Benefits using Magnification Loupes to Improve Dental Work Performance
Authors: Juan Carlos Ortiz Hugues
Published: August 2023

Stress, pain, injuries, and errors in dental procedures are situations highly linked to dentistry derived from multiple factors making this profession a profession with high physical and mental demand to achieve quality treatment without deteriorating the health of those who perform it, in this case, the dentist, the assistant, and hygienist. The effects of wrong postures, but above all, the lack of knowledge of the proper postures, the modeling of bad habits acquired during the training stage in dental school, and the lack of work guidelines that not only take into account the dentist but also to all the work staff and the methodological organization of dental tasks can be found in the scientific literature. Magnification devices are known to improve vision, precision, and ergonomics in dentistry; advances in the area of ​​high magnification in dentistry are taking place by leaps and bounds. In recent years, a new magnification loupes design has appeared on the market, called ergonomic magnification loupes appeared that stands out from conventional Galilean and Keplerian through the lens (TTL) Flip-up loupes in terms of their postural benefits and is part of the arsenal of magnification loupes to consider in the market. The postural approach of high magnification equipment is necessary for professional practice, where the design of Ergonomic magnification loupes with consideration not only for magnification but also for the operator’s postural health which can have a significant impact on the performance and overall health of the dentist and hygienist, more if incorporated from the beginning of dental school education and training.
GREEN ECONOMY AS A FACTOR OF SUSTAINABLE DEVELOPMENT
Authors: Tomashuk Inna , Baldynyuk Vasyl , Boltovska Liudmyla
Published: August 2023

The purpose of the article is to study the directions of development of the green economy in Ukraine as a factor of ensuring the transition to sustainable development of the country. Methodology. One of the main elements of the methodology for conducting research on the green economy as a factor of ensuring sustainable development are evaluation methods. Comparative, balance, graphic, economic-mathematical and other methods of economic justification are used in the work. The methods of systematisation and generalisation were used to study the principles of further ecologically balanced development, economic-statistical, structural-logical and analytical – for the development of methods and indicators for the analysis of the system of directions of the green economy, graphic – for the visual presentation of the dynamics of indicators of sustainable development. The results of the work show that the growth of income and employment in the green economy is guaranteed at the expense of public and private investments aimed at increasing energy efficiency, reducing the negative impacts of economic activity and increasing the diversity and productivity of the biosphere, in the interests of the entire population, especially the poorest. It is important to emphasise that the concept of the green economy does not replace the concept of sustainable development, but develops it and is a means of putting it into practice. Green development can only be ensured if environmental and economic policies are integrated in such a way that social progress, economic growth and improvement in the quality of life of the population take place against a background of reduced threats to the surrounding natural environment. Practical implications. The concept of green growth emphasises the importance of integrating environmental and economic policies in order to identify new potential sources of economic growth without placing an "unsustainable" burden on the quantity and quality of natural resources. The transition to a green economy requires the application of a wide range of measures, including economic instruments (taxes, subsidies, emissions trading schemes), government regulatory measures (setting standards) and non-economic measures (voluntary initiatives, provision of information). Value/originality. Important economic indicators of sustainable environmental and economic development are a nature-intensive economy and a structural indicator that reflects the specific weight of products and investments in the natural resource-based sectors of the economy.
FOREIGN EXPERIENCE IN IMPLEMENTING DIGITAL EDUCATION IN THE CONTEXT OF DIGITAL ECONOMY TRANSFORMATION
Authors: Voronkova Valentyna , Nikitenko Vitalina , Vasyl'chuk Gennadiy
Published: August 2023

The relevance of the research topic is that the study of foreign experiences in the implementation of digital education in the context of digital economic transformation is of great importance. In the context of digitalisation, developed countries are implementing digitalisation policies to promote the digital transformation of education, focusing on improving digital literacy and digital competence. The purpose of the study is to conceptualise the foreign experience of implementing digital education in the context of digital economy transformation. This study aims to examine the global implementation of digital education as a social and economic phenomenon. This study focuses on exploring the impact of the digital economy on the transformation of digital education. The research will focus on: (1) reflections on the concepts of digitalisation of education in advanced countries such as the USA, Japan, India, South Korea, Australia, the UK, Germany and China; (2) definition of connotations and attributes of the digital economy; (3) identification of smart education as a condition for the transformation of the digital economy. According to the study, advanced countries are adopting smart education concepts as a crucial step towards digitalising education to achieve a balance in developing high-quality education, enhancing its quality, expanding opportunities, and promoting the formation of lifelong digital competenciesIt is concluded that the promotion of higher education as a "smart digital transformation reform" contributes to the creation of a new educational environment in the digital age, providing convenient channels for obtaining digital resources. Informatisation of education as a factor of digital transformation has created new opportunities, provided students with intelligent data for learning, given a new impetus to education reform, facilitated large-scale individualised learning, and formed innovative concepts for implementing smart education as an extension of the capabilities of digital technologies and the impact of the digital economy on the transformation of digital education.