bluuebunny/crossref_metadata_2025 huggingface dataset:
Predictors of hyporesponsiveness to erythropoietin in prevalent hemodialysis patients and its association with mortality
Authors:   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Roldão Marisa , Duarte Rui ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Escoli Rachele ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Gonçalves Hernâni ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Sofia Flora ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Lopes Karina ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal
Published: April 2022

Introduction: Erythropoietin-stimulating agents hyporesponsiveness is common among hemodialysis patients. The aim was to analyze factors predictive of Erythropoietin-stimulating agent resistance and its association with mortality. Subjects and methods: Retrospective analysis of prevalent hemodialysis patients. Dose–response effect of Erythropoietin-stimulating agent therapy was evaluated using Erythropoietin-stimulating agent resistance index (ERI). Patients were classified in groups (ERI≤10 and ERI>10). All-cause mortality was assessed using standard survival methods. Results: Among 59 patients, 24 had ERI>10. Patients with ERI >10 had more central venous catheters, higher C-reactive protein levels, lower body mass index, serum iron, transferrin saturation, albumin and intact parathormone levels. Hyporesponsive patients had an increased risk of one-year mortality. Discussion and conclusion: Our study confirmed that malnutrition, inflammation, and iron deficiency are the main causes of Erythropoietin-stimulating agent hyporesponsiveness, and intact parathormone levels and central venous catheter use may also play a role. Erythropoietin-stimulating agent resistance appear to be associated with an increased mortality risk among prevalent hemodialysis patients.
Low income is associated with late nephrology referral in Portugal: A retrospective study
Authors:   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Duarte Rui , Trigo Filipa ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Luz Ivan ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Santos Paulo ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Lopes Karina ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Gonçalves Hernâni ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Sofia Flora ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal, Vila Lobos Ana ,   Department of Nephrology, Centro Hospitalar do Médio Tejo, Torres Novas, Portugal
Published: April 2022

Introduction: Social disparities in chronic kidney disease are a reality. Low socioeconomic status is associated with increased incidence of chronic kidney disease and overall worse outcomes. In Portugal, similarly to many European countries, a National Health System was established to provide equity in healthcare access, but its impact in specialized chronic kidney disease care is unclear. This study aims to compare the effects of economic insufficiency in referral and overall specialized kidney care in a Portuguese center. Subjects and Methods: Retrospective cohort study evaluating maintenance hemodialysis patients of a Public Portuguese Nephrology Center from 2017 through 2021. Medical records were compared for presence of low-income status, with primary outcome as baseline estimated glomerular filtration rate at Nephrology referral and secondary outcomes as presence of kidney replacement therapy options appointment, timely vascular access assessment and time to dialysis from referral. Results: A total of 212 participants were evaluated, 96 with low-income status. This group presented higher serum creatinine and lower estimated glomerular filtration rate at referral (2.35 vs. 3.29 mg/dl, p<0.001; 27.63 vs. 18.47 ml/min/1.73 m2, p<0.001; respectively). Low-income status associated with absence of kidney replacement therapy options appointment (OR 2.7, 95% CI: 1.44-5.08; p=0.003) and late vascular access evaluation (OR 2.77, 95% CI: 1.55-4.98, p=0.001). Dialysis-free survival analysis revealed shorter time to dialysis in the low-income status group (15.77 vs. 20.71 months, p<0.001) with a higher cumulative incidence in dialysis at 24 months (HR: 2.11, 95% CI: 1.39-3.21, p < 0.001), a difference that was not verified after adjusting for estimated glomerular filtration rate at referral (HR: 1.16, 95 % CI: 0.74 – 1.80, p = 0.53). Conclusion: Low-Income chronic kidney disease Portuguese patients are at risk for late Nephrology referral, an established factor for adverse outcomes. Shorter time to dialysis appears significative in reducing adequate kidney care access, which can be attenuated through education of primary care providers and general population for chronic kidney disease.
Oral anticoagulation in patients with atrial fibrillation and end-stage kidney disease
Authors:   Instituto de Ciências Biomédicas Abel Salazar da Universidade do Porto (ICBAS/UP), Porto, Portugal, Azevedo Tânia , Correia Sofia ,   Serviço de Nefrologia, Centro Hospitalar Universitário do Porto (CHUP), Porto, Portugal
Published: April 2022

Atrial fibrillation is highly prevalent in patients with end -stage kidney disease. For patients with atrial fibrillation but normal kidney function, the net clinical benefit of oral anticoagulation with vitamin K antagonists and non -vitamin K oral anticoagulants in preventing stroke against the hemorrhagic risk is well -known. However, dialysis patients present unique risk factors that increase ischemic stroke and bleeding events that are not included in the traditional risk scores. These points, in addition to the pharmacokinetic issues related to the use of oral anticoagulants in end -stage kidney disease, raise the question of the safety of these drugs, making it difficult to predict whether the benefit outweighs the risk. Data on this topic in chronic kidney disease stages 4, 5, and 5D patients is sparse and the clinical guidelines are also inconsistent in which is the best approach for these patients. This review gives an overview of the state of the art on this topic, specifically the recommendations of the newest guidelines, then discusses the various risk scores and their pitfalls, and finally summarizes the current knowledge on the possible benefits of Non -vitamin K oral anticoagulants versus Vitamin K antagonists in dialysis patients.
The urine as a diagnostic key for a homozygous EGFR mutation
Authors:   Neonatal Intensive Care Unit. Women, Children and Adolescents Department, Maternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal, Santos Mafalda ,   Paediatrics Department, Hospital Vila Franca de Xira, Lisboa, Portugal, Almendra Margarida ,   Neonatal Intensive Care Unit. Women, Children and Adolescents Department, Maternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal, Bota Sofia ,   Neonatal Intensive Care Unit. Women, Children and Adolescents Department, Maternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal, Ramos Helena ,   Neonatal Intensive Care Unit. Women, Children and Adolescents Department, Maternidade Dr. Alfredo da Costa, Centro Hospitalar Universitário de Lisboa Central, Lisbon, Portugal, Francisco Telma ,   Nephrology Unit, Children and Adolescents Department, Hospital Dona Estefânia, Centro Hospitalar Universitário Lisboa Central, Lisbon, Portugal
Published: April 2022

Primary inherited epidermal growth factor receptor defects have recently been described in severe inflammatory skin disease and diarrhoea case reports. We describe two case reports of female preterm newborns of Roma consanguineous parents who presented both with alopecia and erythroderma/ichthyosis, in addition to nephromegaly at birth in case 1. Later, they both developed hypomagnesaemia and other severe hydroelectrolyte disturbances, recurrent life-threatening sepsis and failure to thrive. Exome sequencing identified a homozygous mutation in the epidermal growth factor receptor, rarely described. Despite optimization of medical supportive care, the prognosis was poor and both patients died before the first year of life. There are few similar cases of epidermal growth factor receptor homozygous mutation reported so far. Our manuscript describes the genetics, clinical presentation, and complex treatment of our two patients, aiming to contribute to new advances in the management of this condition.
Monitoring Multidrug-Resistant Acinetobacter baumannii Infections in the Neurosurgery ICU Using a Real-Time Surveillance System
Authors: Zhu Yuting , Ni Mingzhu , Fang Xiaofang , Lei Tonghua , Sun Yan , Ding Reng , Hu Xiuqiong , Bian Chengxiang
Published: April 2022

Multidrug-resistant Acinetobacter baumannii (MDR-AB) infections are becoming increasingly common. The Real-Time Nosocomial Infection (NI) Surveillance System (RT-NISS) was used to monitor MDR-AB NI in intensive care units (ICUs) to prevent NI outbreaks. Therefore, the RT-NISS was used in the current study to monitor MDR-AB infections in a neurosurgery ICU. Clinical interventions, including recommended antibiotics, bacterial distribution in the patient analysis, and bed adjustments, were carried out based on the monitoring results. The RT-NISS was also used to monitor clinical data, implement, and provide training on NI control. The RT-NISS detected a potential cluster of XDR-AB when five patients admitted to the neurosurgery ICU were tested positive for AB between 11 and 17 June 2019. Only two infected cases originated in the hospital, and there was no NI outbreak. The hospital Infection Control Department took appropriate measures to prevent cross-infection; specifically, an epidemiologic investigation and environmental assessment were conducted, and NI prevention and outbreak management training was provided. In summary, the RT-NISS enhanced the timeliness and efficacy of NI control and surveillance in a neurosurgery ICU.

In order to prevent NI outbreaks, the Real-Time Nosocomial Infection (NI) Surveillance System (RT-NISS) was employed to monitor MDR-AB NI in critical care units (ICU). Based on the monitoring data, clinical actions such as required antibiotics, bacterial distribution in the patient analysis, and bed changes were carried out. In a neurosurgery ICU, the RT-NISS improved the timeliness and efficacy of NI control and surveillance.
Expression Level of the mip, pmp18D, and ompA Genes in Chlamydia abortus Isolated from Aborted Ewes
Authors: Arif Eman Dhahir , Saeed Nahla Mohammad , Rachid Shwan Kamal , Dyary Hiewa Othman , Rashid Peshnyar M.A.
Published: April 2022

In this manuscript, we report the proteins macrophage infectivity potentiator (mip, CAB080), major outer membrane protein (momp, CAB048), and polymorphic outer membrane protein (pmp18D, CAB776) that are expressed in different times of pregnancy in mice infected with Chlamydia abortus. Enzootic abortion of ewes (EAE) by C. abortus, an obligate intracellular pathogen, is a critical zoonotic disease-causing significant economic loss to livestock farming globally. This study was carried out for the detection and characterization of macrophage infectivity potentiator (mip, CAB080), major outer membrane protein (momp, CAB048), and polymorphic outer membrane protein (pmp18D, CAB776) using RT-qPCR. These proteins are believed to be expressed as virulence factors in C. abortus isolated from aborted ewes. BALB/c mice (pregnant and nonpregnant) were used as an animal model to be injected intraperitoneally with C. abortus culture in Vero cells since the endometrial lymphoid tissues of these animals resembles that of ewes. Also, the short duration of pregnancy in mice makes them a suitable animal model for obstetric studies. Tissue samples were taken from the mice after 10, 15, and 20 days of pregnancy to compare the expression of the genes mip, pmp18D, and ompA. Transcription level was quantified using RT-qPCR, the GAPDH transcription quantification, as a normalization signal. Abortion occurred in pregnant mice, and apparent differences between the transcriptional levels of the mip, pmp18D, and ompA genes in the samples taken during different time intervals of pregnancy were not observed (p > 0.05). The result indicated that the three bacterial genes, mip, pmp18D, and ompA, play a role as virulence factors in abortion and are differentially expressed in pregnant and nonpregnant animals. Inactivation of the genes is suggested to confirm the hypothesis.
Propensity Score Matched Study of Tri-Weekly vs. Weekly Platinum-Based Chemotherapy Concurrent with Radiotherapy in the Treatment of Locally Advanced Cervical Cancer
Authors: Thephamongkhol Kullathorn , Lertkhachonsuk Arb-aroon , Sitathanee Chomporn , Alisanant Petch , Amornwichet Napapat , Khorprasert Chonlakiet , Bridhikitti Jidapa , Korpraphong Pornpim , Muangsomboon Kobkun , Phongkitkarun Sith , Srirattanapong Saowanee , Prapruttam Duangkamon , Dendumrongsup Thaworn , Sasiwimonphan Kewalee , Tanprasertkul Chamnan , Dhanachai Mantana , Patumanond Jayanton , Setakornnukul Jiraporn
Published: April 2022

Objective: To compare tumor control and toxicity between tri-weekly chemotherapy and weekly platinum-based chemotherapy in locally advanced cervical cancer using the propensity score matching method.Material and Methods: DESIGN: Retrospective cohort with propensity score matched population. SETTING: Four university hospitals. PARTICIPANTS: 781 advanced local cervical cancer patients. INTERVENTION: tri-weekly platinum-based chemoradiotherapy versus weekly chemoradiotherapy OUTCOMES: Overall survival (OS), local recurrence-free survival (LRFS), regional recurrence-free survival (RRFS), distant metastasis-free survival (DMFS), and toxicity, including hematological and renal toxicity.Results: Overall median follow-up time was 59.5 months. After the propensity score matching process was completed, 326 patients were analyzed (163 in each group). The five-year OS was 66% and 64% (p 0.630); five-year LRFS was 85% and 81% (p 0.209); five-year RRFS was 89% and 94% (p 0.307); and five-year DMFS was 75% and 79% (p 0.420) in the tri-weekly and weekly groups, respectively. The patients in the tri-weekly and the weekly group had grade 2-3 neutropenia (10.5% vs 2.5%). The other toxicities appeared to be similar in both groups in terms of white blood count, platelet and creatinine.Conclusion: There was a potential small benefit of local control (4%) and overall survival (2%) with the tri-weekly regimen but we could not demonstrate statistical significance. However, this came at the price of an increase of 7% to 8% in grade 2-3 neutropenia.
The first achievement of complete remission in childhood leukemia by treatment with the folic acid antagonist aminopterin
Authors: Izraeli Shai
Published: April 2022

TITLE Temporary remissions in acute leukemia in children produced by folic acid antagonist, 4-aminopteroyl-glutamic acid (aminopterin).

AUTHORS Farber S, Diamond LK. Mercer RD, Slyvester RF Jr, Wolff JA.

JOURNAL New England Journal of Medicine. 1948;238(23):787-793. https://pubmed.ncbi.nlm.nih.gov/18860765/
Cooperative routing in wireless multimedia sensor network with deep learning based decision making system
Authors: M Nagalingayya , Mathpati Basavaraj S
Published: April 2022

Wireless Multimedia Sensor Networks (WMSNs) provide great attention on various attractive applications and their scientific researches due to their potential impact. For the past few years, the most active area related to the research field is routing in WMSNs. Moreover, the multimedia data is transmitted based on the routing protocol for determining the efficient resources and stable path, and also provides different levels of Quality-of-Experience (QoE)/Quality-of-Service (QoS) assurance. Still, it is the difficult aspect based on the complicated operations of multimedia applications, dynamic changes of network condition and limited network resources. This paper intends to introduce a Deep Belief Network (DBN) oriented decision making system to select the suitable cooperative nodes. Moreover, constraints like (i) Tri-level energy consumption of nodes-Level 1: Low energy level for text information, Level 2: Medium energy level for text, image and video information, Level 3: High energy level for high definition pictures (ii) Reliability, and (iii) Delay are examined while transmitting the multimedia information in the network. To make the precise decision, it is planned to tune the optimal weight of DBN by a new hybrid Dragon Integrated Firefly (DIFF) algorithm that combines the concept of Firefly Optimization (FF) and Dragonfly Optimization (DA) algorithm. At last the performance of the adopted scheme is computed over other traditional schemes with respect to alive nodes, delay, residual energy, network lifetime and reliability analysis.
A novel Sugeno type 2 Fuzzy system for finding error positions applying localization in wireless sensor network
Authors: Ghosh Ramkrishna
Published: April 2022

In various usages where Wireless Sensor Networks (WSNs) have been utilized, this is vital to identify wherefrom Sensor nodes (SNs) or which position valuable details is attained. The Global Positioning System (GPS) is traditionally utilized to find out position. Nevertheless, GPS schemes are not perfect for various usages because of their extreme power utilization and high charge. As a substitute to GPS, distance and position may be approximated during the practice of more than three SNs with identified positions. Received Signal Strength Indication (RSSI) is the easiest and largely economical method applied to decide distance and position, and is a criterion aspect on each sensor. Howbeit, RSSI might be influenced through sound and ecological difficulties. Due to this, this is not easy to place up a statistical model for RSSI. The range free technique has various approaches to evaluate the location of SNs in a particular area. In our research work, Centroid localization is employed for development and investigation. RSSI is attained by evaluating the distance between every anchor node (AN) and the SN. Evaluating the position of every SN would be carried out with the help of centroid technique. However, the weights remain the chief metrics in the centroid connection; those are the output of the Sugeno Type 2 fuzzy scheme. Actually, the sugeno type 2 fuzzy technique is obtained RSSIs being inputs to depict the outputs; those are weights of every AN to the SN.
New approach to eliminate noise attendants ECG signal corrupted
Authors: Salih Thair. A.
Published: April 2022

ECG signals have been largely utilized in cardiac pathology to detect heart ailments. ECG signals are commonly corrupted by disparate artifacts such as power line obtrusion exterior electromagnetic domain intervention, noise due to random object motions, breathing motions, and electromyography noise and these should be eliminated before diagnosis.This article explains the creation and performance of three types of band-stop filters based on FPAA technology to accurately estimate an ECG corrupted signal. The characteristics of these filters are improved and their parameters are calculated to minimize the corrupted ECG signals with noise. The Butterworth filter of the fourth order, Notch filters, and least-mean-square adaptive filter (LMSAF) stop-band are used to reduce noise interference from ECG signals. The performance of filters was analyzed by comparing signal power at 62 Hz before and after filtration and distortion to the ECG waveform. It is found that digital filters work satisfactorily. LMSAF gives the best performance as the QRST segment of the ECG signal is less modified compared to others
An instruction detection system with Support Vector Machine, Cuckoo-Genetic algorithm and principal component analysis
Authors: Nayebi F. , M.Noorimehr M.Noorimehr
Published: April 2022

Nowadays, with the abundant growth of internet users, attacks on computer systems have dramatically increased. This condition might increase the risk of security for Internet users or networks systems. Thus, Intrusion Detection Systems (IDS) is used for detection, identification and diagnosis of security issues on computer networks .As a data mining technique, Support Vector Machine (SVM) is considered in the design and implementation of IDS.SVM’s performance is influenced by its parameters and its input feature space respectively. So, in order to reach and achieve a reasonable efficiency of SVM, two values should be optimized: values of parameters for better accuracy, and set of input feature for shorter training time. In this paper, we used Principal Component Analysis (PCA) for feature extraction and dimension reduction of input data and the Cuckoo-Genetic algorithm, as a meta-heuristic optimization technique, to determine the optimum parameters of SVM for classification of normal and malicious data. The practical results, by using proposed method on NSL-KDD dataset, indicates that the proposed method reached a better detection rate Compared to genetic and cuckoo.
Secure medical image steganography based on Discrete Wavelet Transformation and ElGamal encryption algorithm
Authors: Jeevitha S. , N.Amutha Prabha N.Amutha Prabha
Published: April 2022

The latest development in computing methodologies and related steganography based applications had created a novel practice such as telemedicine where patient diagnosis images or allied information can be used diagnosis practices that are located in remote areas. In order to provide accurate and effective telemedicine the flawless or seamless biomedical information is required from patient. With respect to this the medical data may remain prone to get corrupted by hackers or might get manipulated when transmitted through an insecure channel. The cryptosystems which are available are not efficient enough to solve the above mentioned issues. Hence, in this research work a much efficient and effective image steganography technique has been proposed in order to hide the confidential and important image information. We have incorporated Discrete Wavelet Transformation (DWT) technique instead of wavelet transform techniques to embed the secret message in the required cover images. Also, to assure continuous communication through insecure channel, a new model called ElGamal encryption cryptosystem model has been implemented which contains the steganography scheme which has been proposed and developed. To maintain the content of Region of Interest (ROI), Region of Non- Interest (RONI) is used to embed the secret information. The overall performance analysis reveals that the DWT with ElGamal encryption provides more efficient and also have high embedding capacity, imperceptibility when compared to other methods like Hamming code, Syndrome-Trellis Code (STC) and Rivest-Shamir- Adleman (RSA) based methods.
A Study on Compressive Sensing based Clustering algorithms in Wireless Sensor Networks for reduced data transmissions
Authors: Shaamili Varsa G V Shaamili Varsa G V , Mathpati Basavaraj S
Published: April 2022

Energy Efficiency plays a vital role in Wireless Sensor Networks (WSN) because of the limited battery power of nodes. Data Aggregation techniques help in reducing the redundant data transmissions which results in reduced energy consumption. Compressive Sensing (CS) is one of the effective signal processing techniques which helps in reducing the number of transmissions resulting in improved energy efficiency. Clustering is also a proven method of energy efficient data transmission. Employing the CS technique in cluster based WSN gains advantages of both and the outcome of which is further reduction in energy consumption. In this paper, a review of algorithms which employ CS in cluster based WSN is made and explanation of the same is given in brief. Some algorithms employ plain-CS and some employ hybrid-CS techniques. Using the sparse representation of the data vector in some orthonormal basis, even with smaller number of measurements, the data can be reconstructed accurately. First, we have given the details of compressive sensing and the possible sparse transforms, measurement matrices and data reconstruction algorithms. Then, recent works which exploit CS in clustering algorithms are discussed and comparison of the same is provided.
LEVEL OF COMMUNITY ENVIRONMENTAL SUPPORT FOR STUDENT LEARNING AMONG SECONDARY SCHOOL CHILDREN IN SRI LANKA
Authors: CAREEMDEEN JALAL DEEN
Published: April 2022

The community environment wherein the school is situated is influenced by its members, leaders, and the availability of resources (social, human, and financial). The community environment plays a significant role in supporting the success of educational programmes and supporting the attainment of school goals. Such support can be understood as maintaining school safety, carrying out community learning hours and supporting various school programmes directly in contact with the community. This research was aimed at determining community environmental support for student learning, mainly taking into account gender differences as a factor among secondary school children in Sri Lanka. The study used a survey research design and a questionnaire instrument for data collection. A stratified random sampling technique was used to select 1350 secondary school students. To analyse the data, the research used descriptive analyses such as mean, standard deviation and MANOVA analysis. The results demonstrate that the community environmental support for student learning is was at a moderate level (overall mean of 3.522, overall S.D. of 0.931). MANOVA analysis shows significant differences in community environmental support based on gender as community support for female student learning is significantly higher than male students. The implications of the study indicate that community organisations can still increase their academic support in their city or village. Local community organisations can organise educational seminars and workshops, be involved in improving the school’s physical environment and infrastructure, sponsor events, provide financial assistance for specifically male students as well as female students.
FACTORS CONTRIBUTING TO ATTRITION IN ESL AMONG NAMIBIAN LEARNERS
Authors: UMA  , NAMUTENYA NAMUKOMBA AILI , BENJAMIN JEYARAJA SHEREEN SHAMALA , MANIAM MAHENDRAN
Published: April 2022

This study aimed to examine factors contributing to attrition in ESL among learners in Namibia. This study used the convergent parallel mixed methods. There were 50 participants randomly selected to participate in this research. The data was analyzed and merged to validate the findings. The findings indicated that most of the teachers have agreed that their learners do not use ESL often, lack motivation, and have an undesirable attitude towards learning ESL. There was no clear indication of whether age factors affect young learners from losing ESL. The study suggests further studies to validate the findings. The findings of this study is expected to assist curriculum designers in Namibia and other neighbouring countries.
Survival Analysis of Pediatric Wilms Tumor Based on Risk Identification
Authors: Andy Andy , Sigumonrong Yacobda
Published: April 2022

Background: Wilms Tumor (WT) or nephroblastoma is the most common primary malignant tumor of the kidney found in children (comprising about > 95% of all kidney tumors). The study of WT prognostic factors has not been elaborated enough in Indonesia. This study aimed to determine the prognostic factors of WT patients in Adam Malik Hospital, Medan. Methods: This study was conducted with a retrospective design due to the rarity of WT cases. A total of 21 WT patients diagnosed from 2003 to 2019 were taken from medical records at Adam Malik Hospital, Medan. Univariate and multivariate Cox regression analyses were performed to determine the independent prognostic factors of WT. The primary endpoint of this study was patients’ overall survival (OS) obtained by the Kaplan-Meier analysis on significant variables. Results: From the univariate Cox regression analysis, gender was found to be the sole significant factor (HR = 0.218, p = 0.005) where males have a lower hazard ratio. The multivariate Cox regression analysis yielded an age of diagnosis (HR = 13.860, p = 0.014) and complete tumor removals (HR = 0.056, p = 0.008). The Kaplan-Meier analysis was performed on three significant variables mentioned before. Only gender yielded a significant Mantel-Cox log-rank score (p = 0.002) with male patients found to have better survivability with a median survival of 476 days compared to that of females of 11 days. The three-year survival of males was 45.45% while all females did not survive until the cut-off. Conclusions: Three prognostic factors, including children’s gender, age of diagnosis, and tumor removal status, were confirmed to be prognostic factors for the overall survival of children with WT. Further studies covering broader demographic areas were suggested to confirm significant results.
Técnicas conservacionistas de solo e água na agropecuária: Caracterização da área de contribuição de barraginhas
Authors: Peixoto Rosimery Martins , Giongo Pedro Rogerio , Backes Clarice , Silva Patrícia Costa
Published: April 2022

Por meio desta pesquisa, objetivou-se caracterizar as áreas de implantação de barraginhas distribuídas em áreas com usos agropecuários com a utilização do geoprocessamento, além de avaliar a percepção dos produtores quanto a oferta de água. Foram utilizadas as coordenadas geográficas (pontos vetoriais) de locais de construção de barraginhas em propriedades rurais nos municípios de Corumbá de Goiás, Abadiânia, Alexânia e Silvânia, GO. Para caracterização dessas barraginhas, e sua área de influência foram aplicadas técnicas de geoprocessamento com produtos como: uso e cobertura do solo, classes de solos, hipsometria e declividade do terreno. Todas as informações foram inseridas e analisadas por meio do software QGIS 3.10. Para avaliar a percepção dos produtores quanto a oferta de água nas nascentes e período de seca, foi aplicado um questionário. A instalação das barraginhas tem sido distribuidas em áreas com acentuada declividade do terreno, comprimento de rampa inferior a 100m (na maioria das propriedades), o maior número de barraginhas implantada foram em áreas com maior declividade e comprimento de rampa, e solos da classe dos Latossolos. O uso de imagens de satélite, produtos morfométricos, e técnicas de geoprocessamento, indicam a utilização potencial dessas ferrametas para a aplicação em áreas de conservação do solo e água. Segundo os produtores, as barraginhas proporcionam benefícios para a agropecuária por meio do aumento da oferta de água em nascentes e nos períodos de seca nos corpos hidricos locais.
Eficiência reprodutiva e produtiva em ovelhas Corriedale brancas e naturalmente coloridas
Authors: Costa Pablo Tavares , Mendonça Gilson de , Vaz Ricardo Zambarda , Brum Larissa Picada , Bragagnollo Maurício Prestes , Vieira Thiago Pereira
Published: April 2022

O objetivo deste trabalho foi avaliar a influência do fenótipo na eficiência reprodutiva de ovelhas e o desempenho dos cordeiros do nascimento ao desmame. Foram utilizadas 111 ovelhas adultas da raça Corriedale (54 naturalmente coloridas e 57 brancas), mantidas em pastagem natural, suplementadas no terço final da gestação e pastoreadas em pastagem natural melhorada após o parto. Os acasalamentos foram realizados por inseminação artificial e monta controlada. Após o nascimento, os cordeiros foram pesados em intervalos médios de 28 dias e desmamados a idade média de 146 dias. O delineamento experimental foi o inteiramente casualizado, onde cada ovelha representou uma unidade experimental. As variáveis resposta contínuas foram submetidas à análise de variância e as discretas ao teste Qui-quadrado. O peso e a condição corporal pré-acasalamento das ovelhas, os percentuais de prenhez, parição, gemiparidade, perdas durante a gestação, peso dos cordeiros ao nascimento e a taxa de mortalidade até o desmame não diferiram entre os grupos (P>0,05). Ovelhas Corriedale brancas apresentaram maior taxa de desmame de cordeiros (P<0,05). O fenótipo (materno e filial) influenciou o ganho médio diário de peso e o peso ao desmame dos cordeiros (P<0,05). O fenótipo naturalmente colorido das ovelhas ou dos cordeiros determina maiores pesos ao desmame destes últimos, independente da coloração da progenitora.
Effects of m-Health interventions on physical activity level and sedentary behavior in pre-hypertensive and hypertensive individuals: a systematic review
Authors: Martins Aline de Oliveira , Goessler Karla Fabiana , De Marchi Ana Carolina Bertoletti
Published: April 2022

This study aims to identify the effects of m-Health interventions on physical activity (PA) level and sedentary behavior (SB) in pre-hypertensive and hypertensive adults. Therefore, a systematic literature search was conducted according to the guidelines defined by the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA), in the scientific databases Web Of Science, MEDLINE/PubMed, SciELO, Scopus, and ACM Digital Library. Eligibility criteria were: clinical trials; description of the functionalities of m-Health apps (reminders, goals, wearables); description of the intervention characteristics (i.e., duration, expertise of professionals involved in the supervision, and others) and blood pressure assessment. In the end, 1447 studies were identified, of which 147 were duplicates. Through the screening by titles and abstracts, 43 studies were classified as relevant. However, only 12 studies met the eligibility criteria and were included in this systematic review. Most studies presented favorable results with the use of m-Health apps to increase PA and reduce SB. In addition, increasing PA and reducing SB might be an important non-pharmacological therapy to decrease blood pressure in  hypertensive patients, when they follow the minimum recommendations proposed by the PA guidelines of the World Health Organization (WHO). However, further studies are still needed to assess the relationship between SB, PA and the use of m-Health interventions.
Impact on interprofessional collaboration and oral health-related quality of life from a prenatal care protocol: a mixed method study
Authors: Faquim Juliana Pereira da Silva , Buiatti Natália Bernardes Palazzo , Frazão Paulo
Published: April 2022

Objective. The aim was to evaluate the potential impact on interprofessional collaboration and oral health-related quality of life from a prenatal care protocol. Method. We conducted an intervention study, with a post-test control group within a mixed-methods approach. The study population comprised 60 pregnant and health professionals enrolled in primary healthcare units. In the tested protocol, oral health technician was an important link with other members of multi-professional teams in the conversation wheels within which values, perceptions, behaviors and needs of pregnant women were shared about changes experienced during the pregnancy. Numerical data and narratives were used to assess self-rated oral health, oral health-related quality of life measured by OHIP-14, perception of pregnant women on interprofessional practices. Results. Patients were young and had incomplete or complete high school with no significant differences between the test and control groups. The perception of women in relation to  interprofessional collaboration was greater in the intervention group than in control group. Self-rated oral health and oral health-related quality of life improved after intervention. Conclusions. The intervention encouraged the empowerment of the team to refocus the work process with greater involvement and collaborative professional interaction favored by oral health technician performance. The service organization protocol caused tensions and produced positive effects on interprofessional collaboration and on oral health-related quality of life. Clinical Relevance. The findings showed the relevance of the oral health technician’s performance integrating the activities between dental team and multidisciplinary professional team for quality of life related to oral health and interprofessional collaboration.
Potentialities of Fermented Cashew Apple Bagasse with Penicillium roqueforti ATCC 10110: Total Phenolics, Antifungal Activity and Cytotoxicity
Authors: Felix Antonio Carlos Santos , Fernandes Givanildo Luís , Sousa Aleson Pereira de , Oliveira Filho Abrahão Alves de , Lima Edeltrudes de Oliveira , Valasques Junior Gildomar Lima , Nascimento Junior Baraquizio Braga do
Published: April 2022

In this study, cashew apple (Anacardium occidentale L.) bagasse, a residue from the industrial extraction of the juice, was subjected to a solid-state fermentation process with the fungus Penicillium roqueforti ATCC 10110 and the total phenolic content was evaluated, as well as the activity of extracts against strains of dermatophyte fungi of the genera Trichophyton and Microporum; cytotoxicity was analyzed through hemolytic potential in human erythrocytes. The results showed that the fermented cashew apple bagasse had a higher content of total phenolics compared to the unfermented bagasse, a potent antifungal activity with minimum inhibitory concentrations (MIC) ranging from 256 to 512 μg/mL against the strains: T. rubrum (LM-115 and LM-629), T. mentagrophytes LM-119, M. gypseum LM-512 and M. canis (LM-68 e LM-110), with low cytotoxicity. Therefore, the fermented extracts of cashew apple bagasse can be considered as a promising natural non-toxic product for studies in the development of agents against skin diseases, especially for the treatment of dermatophytosis.
Análise sistemática da literatura sobre o uso do rejeito de lama vermelha para a produção de agregados sintéticos leves
Authors: Cunha Júnior Adiel José Passos da , Costa Dênis Carlos Lima , Macêdo Alcebíades Negrão
Published: April 2022

A lama vermelha é o principal subproduto proveniente do beneficiamento da bauxita, conhecido mundialmente como processo Bayer. Sua produção é crescente em todo o mundo, tendo como destaque no Brasil, os estados do Pará e Minas Gerais. No entanto, devido às características químicas deste rejeito, bem como a alta quantidade que é gerada, os órgãos ambientais vêm exigindo cada vez mais que as fontes geradoras criem métodos de reutilização deste rejeito, a fim de colaborar com a logística reversa deste material. Nesse sentido, diversos estudos têm sido realizados visando o reaproveitamento da lama vermelha para a produção de novos materiais, dentre os quais se destaca o agregado leve, que pode ser empregado no setor da construção civil, que é uma das maiores fontes consumidoras deste tipo de produto. Neste viés, o presente estudo avaliou, a partir de uma revisão sistemática da literatura, o potencial de aplicação da lama vermelha na fabricação de agregados leves. Dados importantes como: composição química; densidade; granulometria; resistência mecânica; absorção de água; temperatura de sinterização e aplicação em concretos foram analisados e comparados com as normas pertinentes sobre o assunto. Os resultados são animadores, comprovando que em todos os parâmetros analisados os agregados reciclados produzidos atenderam aos padrões normativos exigidos atualmente, tendo desempenho semelhante aos de agregados convencionais. Concluiu-se, portanto, que a lama vermelha possui viabilidade técnica para fabricação de agregados leves, confirmando a potencialidade da logística reversa do rejeito para este fim.
Bora Jogar: desenvolvimento de jogos para auxiliar na aprendizagem de programação
Authors: Bezerra Ana Paula Berto , Batista Ewerthon Dyego de Araújo , Sousa Jamile Farias de , Olegário Taynná de Almeida , Evangelista Eliel Bento , Lira Romeryto Vieira
Published: April 2022

Introdução: a desistência de alunos sempre foi um problema na área da tecnologia da informação, e uma das principais causas que influenciam é a dificuldade que os estudantes apresentam em aprender programação. Visando amenizar esse problema, o presente artigo se baseia na gamificação para aprimorar e facilitar o estudo de programação através da criação de jogos de tabuleiro e digitais. Objetivo: criar jogos de tabuleiro e digitais para auxiliarem no ensino e no aprendizado de programação para alunos iniciantes. Metodologia:  o projeto foi dividido em quatro fases:  busca de artigos relacionados à utilização de jogos e a facilitação do aprendizado de alunos na programação; logo após, a partir das respostas de um survey, desenvolvido anteriormente, os temas usados para criar os jogos foram escolhidos, houve a implementação da versão em tabuleiro e da versão digital dos jogos. Resultados: a partir da busca de materiais que tivessem relação com o tema, foram selecionados seis artigos relevantes para análise, de acordo com os critérios de inclusão e exclusão pré-determinados; a partir dos resultados da pesquisa que foi produzida com o intuito de detectar as maiores dificuldades dos alunos na disciplina de Algoritmos e Lógica de programação, foram obtidas as respostas que ajudaram a nortear a produção dos jogos. As versões em tabuleiro foram produzidas com o draw.io, um editor de gráficos online, e as versões digitais foram desenvolvidas com a ferramenta Flippity, usada para criar diferentes tipos de jogos.
Manifestações clínicas relacionadas ao sistema nervoso decorrentes da COVID-19: uma revisão integrativa
Authors: Lima Bianca Sampaio , Cardoso Brenda Ellen Meneses , Teixeira Louise Ribeiro , Bastos André Pessoa Silva de , Paz Francisco Lucas Lima , Ferreira José Guilherme de Oliveira Rodrigues , Mendonça Gabriela de Souza , Pacheco Rafaela Costa , Araújo Larruama Soares Figueiredo de , Albuquerque Humberto Gabriel de , Sousa Filho Charles Ponte de , Araujo Ligia Viana de , Jesus Joilson Ramos de , Souza Luan Kelves Miranda de
Published: April 2022

Objetivo: analisar as principais afecções neurológicas decorrentes da infecção pelo vírus SARS-CoV-2 (síndrome respiratória aguda grave de coronavírus 2) através de uma revisão integrativa. Metodologia: trata-se de um estudo de revisão integrativa da literatura. Para a seleção dos artigos foram usadas duas bases de dados: PUBMED e Scielo, e estabeleceram-se como critérios de inclusão: estudos de relato de caso e estudos clínicos, realizados em seres humanos, disponíveis em inglês, espanhol e português, atribuindo-se o recorte de tempo de 1 ano (2020-2021). A amostra final utilizada nesta revisão foi de 36 artigos. Resultados e discussão: apesar de o alvo principal ser o sistema respiratório humano, o coronavírus apresenta potencial neurotrópico e neuroinvasivo, possuindo capacidade de atingir o sistema nervoso central (SNC). Assim, os estudos mostraram associações entre a infecção por SARS-Cov-2 e a ocorrência de cefaleia, encefalopatia, doença cerebrovascular, hemorragia cerebral, encefalomielite, prejuízo da consciência e delírio, convulsões tônico-clônicas, prejuízos no olfato e no paladar, síndrome de Guillain-Barré, rabdomiólise, doença de Parkinson, Alzheimer e esclerose múltipla. Conclusão: a partir da atual revisão de literatura, infere-se que as taxas de comprometimento neurológico em casos de COVID-19 são significativas e demandam o desenvolvimento de mais estudos sobre o tema.
Análise temporal da precipitação no município de Paudalho-PE nos últimos 25 anos
Authors: Medeiros Raimundo Mainar de , Araújo Wagner Rodolfo de , Holanda Romildo Morant de , Saboya Luciano Marcelo Fallé , Cunha Filho Moacyr , França Manoel Vieira de
Published: April 2022

The semi-arid region has peculiar characteristics, among them the lack of rainfall for a long period of time. The objective is the temporal analysis of the behavior of the pluviometric regime in the municipality of Paudalho in the last 25 years. The rainfall data were acquired from the Northeast Development Superintendence and the Pernambuco Water and Climate Agency covering the period from 1992 to 2016. The averages, standard deviation, coefficient of variance, maximum and minimum absolute values of the study area were calculated. The local contributions, the Intertropical Convergence Zone, the Maddem - Juliem Oscillation acted with intensity and caused mostly above-normal rainfall in some decades, registering disasters of moderate to intense proportions. In the climatological analysis of rainfall in the municipality under study, the months March to August had the highest rainfall with 77.5% of the annual total and the months from September to February had the lowest rainfall with 22.5% of the annual rainfall.
Aprendizagem da docência no estágio curricular supervisionado em um IF: entre as possibilidades e os desafios
Authors: Oliveira Adrielly Aparecida de , Paniago Rosenilde Nogueira , Nunes Patrícia Gouvêa , Almeida Gisele Assis de
Published: April 2022

O presente estudo almeja identificar as possibilidades e as fragilidades do processo de Estágio Curricular Supervisionado (ECS) do curso de Licenciatura em Química de um Instituto Federal de Educação, Ciência e Tecnologia, denominado IF Campus, para a aprendizagem da docência. Como procedimento metodológico, utilizamos documentos e recolhemos narrativas de oito estagiários de um de Curso de Licenciatura em Química. As questões que conduziram a pesquisa foram: o ECS do IF Campus contribui para a aprendizagem docente? Em que sentido, ocorrem estas contribuições? Quais os limites e fragilidades deste processo? Os resultados sinalizam que o ECS tem contribuído significativamente para a aprendizagem da docência dos estagiários por propiciar a sua aproximação com o ambiente escolar e o desenvolvimento de atividades que possibilitam iniciação à pesquisa. Entretanto, constatamos fragilidades, tais como, falta de articulação entre o ECS e as demais disciplinas do curso e ausência de um efetivo uso de referenciais teóricos para dar suporte ao desenvolvimento de atividades e reflexões no âmbito do ECS.
Prospecção Científica e Tecnológica de Montrichardia linifera (Arruda) Schott com Enfoque na Atividade Anti-helmíntica
Authors: Lima Cleiane Dias , Pires Camila Jorge , Moreira Gleidiany da Costa , Andrade Dallyla Sousa de , Mesquita Emerson Bruno Castro , Sousa Angelo Afonso Ferreira , Carvalho André dos Santos , Fraz Matheus Araújo , Bastos Ruan Sousa , Passos Ionara Nayana Gomes , Rocha Jefferson Almeida
Published: April 2022

A Montrichardia linifera (Arruda) Schott é uma macrófita aquática da família Araceae bastante difundida na medicina tradicional e pouco explorada do ponto de vista científico. Diante disso torna-se uma excelente espécie para exploração do seu potencial biotecnológico. Portanto, objetivou-se com esta pesquisa realizar uma prospecção científica e tecnológica sobre a Montrichardia linifera com enfoque na atividade anti-helmíntica. A prospecção tecnológica foi realizada através da busca de patentes nas bases: EPO, USPTO, DII, INPI e WIPO. Já a busca de trabalhos científicos, foi feita nas bases de dados: SciELO, Bireme, Web of Science, Scopus e Science Direct de 2010
a 2022. Os resultados para patentes mostraram que obteve apenas 3 (três) publicação nas bases internacionais DII e WIPO e na base brasileira INPI 2 (duas) publicações. Na busca científica obteve-se o total de 50 (cinquenta) publicações para o descritor “Montrichardia linifera”, em todas as bases analisadas. Já para o descritor “Montrichardia linifera” and “anthelmintic” obteve-se apenas uma publicação. Dessa forma, percebe-se que ainda são escassos os trabalhos científicos relacionados à M. linifera, necessitando assim mais incentivos. Contudo, investimentos são necessários para a realização de mais pesquisas relacionadas a essa planta com intuito de desvendar suas atividades terapêuticas.