bluuebunny/crossref_metadata_2025 huggingface dataset:
Partitioning Human Dietary Exposure to Ammunition-Derived Lead in Meat from Game Animals Between Bullets and Shotgun Pellets
Authors: Green Rhys E. , Pain Deborah J.
Published: March 2024

In making recommendations for restricting uses of lead shotgun pellets and bullets for hunting, regulatory agencies, including those of EU and UK REACH, estimate human health risks from dietary exposure to lead from both ammunition types separately and attempt to monetise benefits of restriction options. However, available data from diet surveys are rarely sufficient to allow straightforward partitioning of dietary exposure between game killed with lead bullets and shotgun pellets. Because information on game meat consumption was limited, the UK REACH Agency’s draft socioeconomic analysis assigned all health-related economic benefits of lead ammunition restriction to shotgun pellets and none to bullets because a much higher tonnage of shotgun pellets than bullets is used. However, differences between the two ammunition types in exposure pathways make tonnage used an unreliable proxy for dietary exposure. Using primarily data for the UK, we partitioned exposure to lead by estimating tonnages of edible game meat shot with bullets and shotgun pellets separately and the mean lead concentrations in these meats. We estimated that ca.21% of human dietary exposure to ammunition-derived lead in the UK is from bullets and 79% from shotgun pellets. This new partitioning approach could be used to inform cost–benefit analysis in the UK and elsewhere when data from food consumption surveys are lacking.
Literature Survey for In-Vivo Reynolds and Womersley Numbers of Various Arteries and Implications for Compliant In-Vitro Modelling
Authors: Williamson P. N. , Docherty P. D. , Jermy M. , Steven B. M.
Published: March 2024

Purpose

In-vitro modelling can be used to investigate haemodynamics of arterial geometry and stent implants. However, in-vitro model fidelity relies on precise matching of in-vivo conditions. In pulsatile flow, velocity distribution and wall shear stress depend on compliance, and the Reynolds and Womersley numbers. However, matching such values may lead to unachievable tolerances in phantom fabrication.

Methods

Published Reynolds and Womersley numbers for 14 major arteries in the human body were determined via a literature search. Preference was given to in-vivo publications but in-vitro and in-silico values were presented when in-vivo values were not found. Subsequently ascending aorta and carotid artery case studies were presented to highlight the limitations dynamic matching would apply to phantom fabrication.

Results

Seven studies reported the in-vivo Reynolds and Womersley numbers for the aorta and two for the carotid artery. However, only one study each reported in-vivo numbers for the remaining ten arteries. No in-vivo data could be found for the femoral, superior mesenteric and renal arteries. Thus, information derived in-vitro and in-silico were provided instead. The ascending aorta and carotid artery models required scaling to 1.5× and 3× life-scale, respectively, to achieve dimensional tolerance restrictions. Modelling the ascending aorta with the comparatively high viscosity water/glycerine solution will lead to high pump power demands. However, all the working fluids considered could be dynamically matched with low pump demand for the carotid model.

Conclusion

This paper compiles available human haemodynamic information, and highlights the paucity of information for some arteries. It also provides a method for optimal in-vitro experimental configuration.
RGD-coated polymeric microbubbles promote ultrasound-mediated drug delivery in an inflamed endothelium-pericyte co-culture model of the blood-brain barrier
Authors: Hark Christopher , Chen Junlin , Blöck Julia , Buhl Eva Miriam , Radermacher Harald , Pola Robert , Pechar Michal , Etrych Tomáš , Peña Quim , Rix Anne , Drude Natascha I. , Kiessling Fabian , Lammers Twan , May Jan-Niklas
Published: March 2024

Drug delivery to central nervous pathologies is compromised by the blood-brain barrier (BBB). A clinically explored strategy to promote drug delivery across the BBB is sonopermeation, which relies on the combined use of ultrasound (US) and microbubbles (MB) to induce temporally and spatially controlled opening of the BBB. We developed an advanced in vitro BBB model to study the impact of sonopermeation on the delivery of the prototypic polymeric drug carrier pHPMA as a larger molecule and the small molecule antiviral drug ribavirin. This was done under standard and under inflammatory conditions, employing both untargeted and RGD peptide-coated MB. The BBB model is based on human cerebral capillary endothelial cells and human placental pericytes, which are co-cultivated in transwell inserts and which present with proper transendothelial electrical resistance (TEER). Sonopermeation induced a significant decrease in TEER values and facilitated the trans-BBB delivery of fluorescently labeled pHPMA (Atto488-pHPMA). To study drug delivery under inflamed endothelial conditions, which are typical for e.g. tumors, neurodegenerative diseases and CNS infections, tumor necrosis factor (TNF) was employed to induce inflammation in the BBB model. RGD-coated MB bound to and permeabilized the inflamed endothelium-pericyte co-culture model, and potently improved Atto488-pHPMA and ribavirin delivery. Taken together, our work combines in vitro BBB bioengineering with MB-mediated drug delivery enhancement, thereby providing a framework for future studies on optimization of US-mediated drug delivery to the brain.

Graphical abstract
Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length
Authors: Gürel Satı , Pak Elif Nisa , Tek Nilüfer Acar
Published: March 2024

Purpose of Review

The number and proportion of individuals aged 60 and over are increasing globally. The increase in the elderly population has important social and economic effects. Telomere length is an important marker for healthy aging. Here, we review the relevance between telomere length and energy balance by determining the effects of physical activity, nutrients, dietary patterns, and foods on healthy aging and telomere length with related studies.

Recent Findings

Evidence emphasizes the importance of telomere length and integrity for healthy aging. It also focuses on the importance of potential interventions such as physical activity and a healthy diet to improve this process.

We suggest that ensuring energy balance with regular physical activity and healthy diets can contribute to the aging process by protecting telomere length. In addition, different methods in studies, short and inconsistent durations, different types of exercise, different diet patterns, and non-standard foods have led to conflicting results. More studies are needed to elucidate molecular-based mechanisms.
A hybrid modeling approach to simulate complex systems and classify behaviors
Authors: Boodaghian Asl Arsineh , Raghothama Jayanth , Darwich Adam , Meijer Sebastiaan
Published: March 2024

Many important systems, both natural and artificial, are complex in nature, and models and simulations are one of the main instruments to study them. In this paper, we present an approach where a complex social system is represented at a high level of abstraction as a network, thereby addressing several challenges such as quantification, intervention, adaptation and validation. The network represents the factors that influence the mental health and wellbeing in children and young people. In this article, we present an approach that links a system dynamics simulation to simulate the network and ranking algorithms to measure the vertices’ behaviors. The network is enhanced by adding edge strengths in the form of correlations between vertices (established through literature). Such an approach allows us to exploit the network structure to qualify and quantify the vertices of the network, to overlay different processes over the network topology, to add and remove new vertices, and therefore interact dynamically. This in turn allows for the qualification of vertices’ importance and network resilience. System dynamics simulation allows for policy analysis, where different scenarios are analyzed by stimulating a set of vertices and the effect over the network is observed. This approach allows for an abstract, flexible, yet comprehensive way of analyzing a complex social network at any scale.
Electrochemical decolorization of liquid digestate from coffee waste biomass using a boron-doped diamond anode
Authors: Chen H. B. , Yoshida G. , Andriamanohiarisoamanana F. J. , Ihara I.
Published: March 2024

Liquid digestate can be used to provide nutrients for microalgae cultivation but the medium needs to be clear and colorless. The aim of this work was to use liquid digestate from coffee waste biomass to produce a light-permeable medium for microalgae cultivation. A boron-doped diamond anode was applied for electrochemical decolorization of the digestate. The electrochemical oxidation process reduced the platinum-cobalt color value by up to 97% and the chemical oxygen demand by 84.1%. After electrochemical oxidation, 87.4% of the ammonium nitrogen (NH4-N) was retained. Decolorization of the spent coffee grounds liquid digestate was compared with that of dairy cow manure liquid digestate. It took 90 min longer to fully decolorize the spent coffee grounds liquid digestate compared with the dairy cow manure liquid digestate. The boron-doped diamond anode performed better in the decolorization than Ti/IrO2 and Ti/Pt anodes. The effects of the initial Fe2+ concentration and current on the electrochemical oxidation process were also evaluated. Increasing the initial Fe2+ concentration enhanced the Fenton reaction and chemical oxygen demand removal. A higher current enhanced the electrochemical decolorization process and side reactions. Electrochemical oxidation using a boron-doped diamond anode is a promising method for producing an appropriate medium for microalgae cultivation because it promotes decolorization of liquid digestate and retains most of the NH4-N.
Functional Optical Fiber Sensors Detecting Imperceptible Physical/Chemical Changes for Smart Batteries
Authors: Li Yiding , Wang Li , Song Youzhi , Wang Wenwei , Lin Cheng , He Xiangming
Published: March 2024

The battery technology progress has been a contradictory process in which performance improvement and hidden risks coexist. Now the battery is still a “black box”, thus requiring a deep understanding of its internal state. The battery should “sense its internal physical/chemical conditions”, which puts strict requirements on embedded sensing parts. This paper summarizes the application of advanced optical fiber sensors in lithium-ion batteries and energy storage technologies that may be mass deployed, focuses on the insights of advanced optical fiber sensors into the processes of one-dimensional nano–micro-level battery material structural phase transition, electrolyte degradation, electrode–electrolyte interface dynamics to three-dimensional macro-safety evolution. The paper contributes to understanding how to use optical fiber sensors to achieve “real” and “embedded” monitoring. Through the inherent advantages of the advanced optical fiber sensor, it helps clarify the battery internal state and reaction mechanism, aiding in the establishment of more detailed models. These advancements can promote the development of smart batteries, with significant importance lying in essentially promoting the improvement of system consistency. Furthermore, with the help of smart batteries in the future, the importance of consistency can be weakened or even eliminated. The application of advanced optical fiber sensors helps comprehensively improve the battery quality, reliability, and life.
Pathologies in the Asymptotics of low-Froude Free-surface Waves Over Smooth Bodies
Authors: Johnson-Llambias Yyanis , Trinh Philippe H.
Published: March 2024

In the study of low-speed or low-Froude flows of a potential gravity-driven fluid past a wave-generating object, the traditional asymptotic expansion in powers of the Froude number predicts a waveless free-surface at every order. This is due to the fact that the waves are, in fact, exponentially small and beyond-all-orders of the naive expansion. The theory of exponential asymptotics indicates that such exponentially-small water waves are switched-on across so-called Stokes lines—these curves partition the fluid-domain into wave-free regions and regions with waves. In prior studies, Stokes lines are associated with singularities in the flow field, such as stagnation points, or corners of submerged objects or rough beds. In this work, we present a smoothed geometry that was recently highlighted by Pethiyagoda et al. [Int. J. Numer. Meth. Fluids. 2018; 86:607–624] as capable of producing waves, yet paradoxically exhibiting no obvious Stokes line according to conventional exponential asymptotics theory. In this work, we demonstrate that the Stokes line for this smooth geometry originates from an essential singularity at infinity in the analytic continuation of free-surface quantities. We discuss some of the difficulties in extending the typical methodology of exponential asymptotics to general wave-structure interaction problems with smooth geometries.
Hydrothermal synthesis of hydroxyapatite crystals with and without seed crystals and surfactant
Authors: Abdel-Aal E. A. , El-Sayed D. , Abdel-Ghafar H. M.
Published: March 2024

To the best of our knowledge for the first time the hydroxyapatite (HA) crystals were synthesized with different doses of HA seed crystals. HA crystals were synthesized from solutions containing the stoichiometric amounts of ammonium dihydrogen phosphate and calcium hydroxide. The various interactions of the NH4H2PO4 concentrations (0.5–5.5 Molar), surfactant {amino tris (methylene phosphonic acid) [N(CH2PO3H2)3] (ATMP)} [ATMP] concentrations (0–100 ppm), and HA seed crystals doses (0–50%) were investigated and their effects on the HA mean diameter and hardness were studied using the Box-Behnken experimental statistical design. Results have shown that no correlations were obtained between the mean diameters of the HA crystals and the obtained HA hardness. HA synthesis in the absence of surfactant resulted in formation of HA rod-like and/or tabular crystals whereas agglomerated crystals were obtained with surfactant. The results indicate that with increasing the % of HA crystal seed dose, an increase in the HA mean diameter was obtained. Moreover, with increase of surfactant concentration, a high increase in HA hardness was achieved. HA crystal particle sizes were ranged from about 11–18 µm whereas the crystallite sizes were ranged from 22 to 46 nm.
Adding Agricultural Topsoil and Growing Perennial Ryegrass (Lolium perenne L.) Enhanced the Rehabilitation of Metal/loids Enriched Iron Ore Mine Tailings
Authors: Sarathchandra Sajeevee S. , Rengel Zed , Solaiman Zakaria M.
Published: March 2024

Revegetating iron-ore mine tailings is difficult due to their poor physicochemical and microbial properties. This experiment aimed to improve tailings properties for better plant growth and rhizosphere activities. First, a pot experiment was conducted to assess the influence of topsoil amendment on the remediation of tailings collected from two sites (coded A and B) in Western Australia to promote the growth of perennial ryegrass (Lolium perenne L. cv Ausvic). Each pot was filled with pre-defined ratios of topsoil to mine tailings (0, 10, 20, 30, 50 and 100% w/w). Perennial ryegrass was harvested 60 days after sowing and analysed for plant growth, root morphological characteristics and metal uptake by shoots. Second, a study on biological attributes and an incubation study over 84 days were carried out. The addition of topsoil significantly decreased pH, but EC and total organic carbon (TOC) increased with an increased proportion of topsoil. Total concentrations of As, Co, Cr, Cu, Ni, Pb, Zn, Fe and Mn decreased with an increased ratio of topsoil in growth medium. The highest root dry biomass was observed in the treatments with 30% and 50% topsoil addition to tailings, whereas shoot dry biomass only increased with 50% topsoil. Total root length increased significantly with 50% topsoil addition to site A tailings. A significant increase in microbial biomass carbon (MBC) was found with 50% addition of topsoil compared with the control. Microbial quotient (MBC/TOC) decreased significantly with the addition of topsoil to both types of tailings. Metal contents in perennial ryegrass shoots decreased with the increasing rate of topsoil, but perennial ryegrass was an effective phytoextractor of Cu, Zn and Mn. Further, the incubation study revealed that 50% topsoil application increased cumulative respiration emissions in both A and B tailings after 42 days. Iron ore mine tailings can be improved in terms of physicochemical and biological attributes by adding topsoil. However, further investigation should be carried out to determine the speciation of metal/loids in amended iron ore tailings.
Efficient and Homogenous Precipitation of Sulfur Within a 3D Electrospun Heterocatalytic Rutile/Anatase TiO2-x Framework in Lithium–Sulfur Batteries
Authors: Feng Ping , Dong Kang , Xu Yaolin , Zhang Xia , Jia Haojun , Prell Henrik , Tovar Michael , Manke Ingo , Liu Fuyao , Xiang Hengxue , Zhu Meifang , Lu Yan
Published: March 2024

Lithium–sulfur (Li–S) batteries can potentially outperform state-of-the-art lithium-ion batteries, but their further development is hindered by challenges, such as poor electrical conductivity of sulfur and lithium sulfide, shuttle phenomena of lithium polysulfides, and uneven distribution of solid reaction products. Herein, free-standing carbon nanofibers embedded with oxygen-deficient titanium dioxide nanoparticles (TiO2-x/CNFs) has been fabricated by a facile electrospinning method, which can support active electrode materials without the need for conductive carbon and binders. By carefully controlling the calcination temperature, a mixed phase of rutile and anatase was achieved in the TiO2-x nanoparticles. The hybridization of anatase/rutile TiO2-x and the oxygen vacancy in TiO2-x play a crucial role in enhancing the conversion kinetics of lithium polysulfides (LiPSs), mitigating the shuttle effect of LiPSs, and enhancing the overall efficiency of the Li–S battery system. Additionally, the free-standing TiO2-x/CNFs facilitate uniform deposition of reaction products during cycling, as confirmed by synchrotron X-ray imaging. As a result of these advantageous features, the TiO2-x/CNFs-based cathode demonstrates an initial specific discharge capacity of 787.4 mAh g−1 at 0.5 C in the Li–S coin cells, and a final specific discharge capacity of 584.0 mAh g−1 after 300 cycles. Furthermore, soft-packaged Li–S pouch cells were constructed using the TiO2-x/CNFs-based cathode, exhibiting excellent mechanical properties at different bending states. This study presents an innovative approach to developing free-standing sulfur host materials that are well suited for flexible Li–S batteries as well as for various other energy applications.

Graphical Abstract
The digital divide in action: how experiences of digital technology shape future relationships with artificial intelligence
Authors: Bentley Sarah V. , Naughtin Claire K. , McGrath Melanie J. , Irons Jessica L. , Cooper Patrick S.
Published: March 2024

The digital divide remains an ongoing societal concern, with digital exclusion shown to have a significantly detrimental impact on people’s quality of life. Artificial intelligence (AI), the latest wave of digitalisation, is being integrated into the fabric of society at an accelerated rate, the speed of which has prompted ethical concerns. Without addressing the digital divide, the AI revolution risks exacerbating the existing consequences of digital exclusion and limiting the potential for all people to reap the benefits provided by AI. To understand the factors that might contribute to experiences of AI, and how these might be related to digital exclusion, we surveyed a diverse online community sample (N = 303). We created a novel measure of digital confidence capturing individual levels of awareness, familiarity, and sense of competence with digital technology. Results indicated that measures of digital confidence were predicted by structural, behavioural, and psychological differences, such that women, older people, those on lower salaries, people with less digital access, and those with lower digital well-being, reported significantly less digital confidence. Furthermore, digital confidence significantly moderated the relationship between people’s experiences with everyday AI technologies and their general attitudes towards AI. This understanding of the spill-over effects of digital exclusion onto experiences of AI is fundamental to the articulation and delivery of inclusive AI.
Gender Tapestry: gender classification as color assignation
Authors: Rosenbaum J.
Published: March 2024

Gender Tapestry is a multi-stage interactive AI art project, challenging traditional gender classification systems. This project diverges from binary approaches by recognizing the individuality of the gender experience and expression. This paper draws parallels to the ways color perception differs amongst people and how gender is also experienced in different ways due to lived experiences. Gender Tapestry uses a multi-label classification system, with predictions extending across six gender categories, with a custom RGB color generated based on the outcomes. Participants receive binary images of their face in their personalized colors and styles, while their uploaded photos contribute to a live Generative Adversarial Network training process. This work was created in response to the very binary representations of gender in AI and the lack of representation for genders outside of the binary. The culmination is an evolving mosaic artwork, incorporating all users' custom colors, illustrating gender as a fluid construct. The mosaic gains in complexity as more images are added and more colors enter the mix, creating a community artwork on gender as a 3D color spectrum. This work contributes to the discourse on diversity and inclusion in AI, emphasizing the fluidity of gender and fostering unconventional artistic representations.
Maize multi-omics reveal leaf water status controlling of differential transcriptomes, proteomes and hormones as mechanisms of age-dependent osmotic stress response in leaves
Authors: Niu Liangjie , Wang Wenkang , Li Yingxue , Wu Xiaolin , Wang Wei
Published: March 2024

Drought-induced osmotic stress severely affects the growth and yield of maize. However, the mechanisms underlying the different responses of young and old maize leaves to osmotic stress remain unclear. To gain a systematic understanding of age-related stress responses, we compared osmotic-stress-induced changes in maize leaves of different ages using multi-omics approaches. After short-term osmotic stress, old leaves suffered more severe water deficits than young leaves. The adjustments of transcriptomes, proteomes, and hormones in response to osmotic stress were more dynamic in old leaves. Metabolic activities, stress signaling pathways, and hormones (especially abscisic acid) responded to osmotic stress in an age-dependent manner. We identified multiple functional clusters of genes and proteins with potential roles in stress adaptation. Old leaves significantly accumulated stress proteins such as dehydrin, aquaporin, and chaperones to cope with osmotic stress, accompanied by senescence-like cellular events, whereas young leaves exhibited an effective water conservation strategy mainly by hydrolyzing transitory starch and increasing proline production. The stress responses of individual leaves are primarily determined by their intracellular water status, resulting in differential transcriptomes, proteomes, and hormones. This study extends our understanding of the mechanisms underlying plant responses to osmotic stress.
Mapping the distribution of tension across paxillin upon shear stress with FRET-based biosensor
Authors: Shao Shuai , Deng Sha , Li Na , Zhang Zhengyao , Zhang Hangyu , Liu Bo
Published: March 2024

Paxillin communicates with multiple signalling molecules in focal adhesions (FAs) and participates in the intracellular force transmission upon shear stress. Thus, paxillin is likely to contribute to establishing the shear stress induced-cell polarity. However, it is still unclear whether the tension across FAs proteins can direct the polarity establishments by providing spatial features, due to a lack of efficient manners. This work proposes a visualization approach containing a DNA-encoded biosensor and fluorescent image processing algorithm to collect the spatiotemporal features of tension across paxillin. The results indicate that the tension across paxillin shows polarity between the upstream and downstream zones of the cell along the direction of shear stress, which was mediated by the membrane fluidity and integrity of the cytoskeleton. It demonstrates that the spatial information from the upper surface of cells upon shear stress can be transmitted to the interior of FAs on the basal layer by the architecture consisting of plasma membrane and cytoskeleton. Paxillin is a potential participant in activating cell polarity by providing a spatial mechanical guide to related signaling molecules upon shear stress.

Graphical Abstract
Status of Sustainability Management Education in African MBA Programmes: A Web-based Research Approach
Authors: Muposhi Asphat , Shamhuyenhanzva Roy
Published: March 2024

Emerging evidence suggests that business schools in Africa are lagging behind in promoting sustainability education. Grand challenges that point to a limited focus on transformative sustainability education such as environmental pollution, conflicts, inequalities and unemployment still persist in African economies, with the profit motive remaining central to businesses’ operating philosophy. Informed by the clarion call for business schools to be key drivers of sustainability education, this study reviews the African master of business administration (MBA) curricula with the objective of assessing the status of sustainability management education. The content of the MBA curricula of 42 African business schools accredited with the Association of African Business Schools was analysed using a web-based research approach. The findings indicate that the concept of sustainability has not been sufficiently embedded into the African MBA curricula. The values and mission statements of the majority of business schools were found not to be aligned with the principles of sustainability education. It was also found that shareholder value oriented modules constitute the core curriculum of the majority of MBA programmes reviewed. An incremental elective approach was found to be the most dominant strategy used by African business schools to incorporate sustainability education in the MBA curricula. An integrative approach of embedding sustainability education focusing on re-orientation of the business schools’ values, mission, curriculum, systems, operations and governance is recommended. The increased use of experiential learning is also recommended as an effective teaching pedagogy for equipping MBA students with practical aspects of sustainability education.
Using the Five Safes to structure economic evaluations of data governance
Authors: Ritchie Felix , Whittard Damian
Published: March 2024

As the world has become more digitally dependent, questions of data governance, such as ethics, institutional arrangements, and statistical protection measures, have increased in significance. Understanding the economic contribution of investments in data sharing and data governance is highly problematic: outputs and outcomes are often widely dispersed and hard to measure, and the value of those investments is very context-dependent. The “Five Safes” is a popular data governance framework. It is used to design and critique data management strategies across the world and has also been used as a performance framework to measure the effectiveness of data access operations. We report on a novel application of the Five Safes framework to structure the economic evaluation of data governance. The Five Safes was designed to allow structured investigation into data governance. Combining this with more traditional logic models can provide an evaluation methodology that is practical, reproducible, and comparable. We illustrate this by considering the application of the combined logic model-Five Safes framework to data governance for agronomy investments in Ethiopia. We demonstrate how the Five Safes was used to generate the necessary context for a more traditional quantitative study, and consider lessons learned for the wider evaluation of data and data governance investments.
Full employment and working future
Authors: Quiggin John
Published: March 2024

Working Nation is not the radical break with the existing policy framework implied by Albanese’s pre-election rhetoric. However, restoring a meaningful definition of full employment as an objective of government policy is a step in the right direction.
From Opposition to Creativity: Saba Mahmood's Decolonial Critique of Teleological Feminist Futures
Authors: Velji Muhammad
Published: March 2024

Saba Mahmood's anthropological work studies the gain in skills, agency, and capacity building by the women's dawa movement in Egypt. These women increase their virtue toward the goal of piety by following dominant, often patriarchal norms. Mahmood argues that “teleological feminism” ignores this gain in agency because this kind of feminism only focuses on opposition or resistance to these norms. In this paper I defend Mahmood's “anti-teleological” feminist work from criticisms that her project valorizes oppression and has no vision for a nonoppressive feminist future. I argue the future envisioned by teleological feminists gets caught in “the Hegelian” trap of replicating past oppression in their feminist future. I find in Mahmood's work the tools to escape this trap. I argue, rather than a movement of overcoming oppression, Mahmood's work suggests an immanent and creative movement that emphasizes difference for a truly new future. I turn to a Bergsonian metaphor and argue that this movement can be seen as akin to the movement of biological evolution. I conclude using the work of Eve Sedgwick that the Egyptian women that Mahmood studies are being read in a “paranoid” fashion and demonstrate using Leila Ahmed a better “reparative” reading of these women.
Spontaneous locomotion of a symmetric squirmer
Authors: Cobos Richard , Khair Aditya S. , Schnitzer Ory
Published: March 2024

The squirmer is a popular model to analyse the fluid mechanics of a self-propelled object, such as a micro-organism. We demonstrate that some fore–aft symmetric squirmers can spontaneously self-propel above a critical Reynolds number. Specifically, we numerically study the effects of inertia on spherical squirmers characterised by an axially and fore–aft symmetric ‘quadrupolar’ distribution of surface-slip velocity; under creeping-flow conditions, such squirmers generate a pure stresslet flow, the stresslet sign classifying the squirmer as either a ‘pusher’ or ‘puller’. Assuming axial symmetry, and over the examined range of the Reynolds number

$Re$

(defined based upon the magnitude of the quadrupolar squirming), we find that spontaneous symmetry breaking occurs in the puller case above

$Re \approx 14.3$

, with steady swimming emerging from that threshold consistently with a supercritical pitchfork bifurcation and with the swimming speed growing monotonically with

$Re$

.
Mass transport at gas-evolving electrodes
Authors: Sepahi Farzan , Verzicco Roberto , Lohse Detlef , Krug Dominik
Published: March 2024

Direct numerical simulations are utilised to investigate mass-transfer processes at gas-evolving electrodes that experience successive formation and detachment of bubbles. The gas–liquid interface is modelled employing an immersed boundary method. We simulate the growth phase of the bubbles followed by their departure from the electrode surface in order to study the mixing induced by these processes. We find that the growth of the bubbles switches from a diffusion-limited mode at low to moderate fractional bubble coverages of the electrode to a reaction-limited growth dynamics at high coverages. Furthermore, our results indicate that the net transport within the system is governed by the effective buoyancy driving induced by the rising bubbles and that mechanisms commonly subsumed under the term ‘microconvection’ do not significantly affect the mass transport. Consequently, the resulting gas transport for different bubble sizes, current densities and electrode coverages can be collapsed onto one single curve and only depends on an effective Grashof number. The same holds for the mixing of the electrolyte when additionally taking the effect of surface blockage by attached bubbles into account. For the gas transport to the bubble, we find that the relevant Sherwood numbers also collapse onto a single curve when accounting for the driving force of bubble growth, incorporated in an effective Jakob number. Finally, linking the hydrogen transfer rates at the electrode and the bubble interface, an approximate correlation for the gas-evolution efficiency has been established. Taken together, these findings enable us to deduce parametrisations for all response parameters of the systems.
Nourishing food, clean air and exercise: medical debates over environment and polar hygiene on Robert Falcon Scott’s British National Antarctic expedition, 1901–1904
Authors: Armston-Sheret Edward
Published: March 2024

The late nineteenth and early twentieth century saw dramatic new developments in climatic medicine, particularly the institutionalisation of thinking about tropical hygiene. There were also more limited efforts to understand how hygiene theories should be applied in a polar environment. Studying the British National Antarctic Expedition (1901–1904), led by Robert Falcon Scott, helps us understand how these practices had both similarities and differences from applications of hygiene in other contexts. The expedition offers unique insights into debates about hygiene, environment, and health because of the important, and well documented, role that medics, naval officers and scientists played in organising logistical arrangements for the journey to Antarctica. In analysing the writings of expedition members and organisers, this paper examines the ways that the universal tools of hygiene theories were applied and developed in a polar environment. Many of the most acute threats seemed to come not from the outside environment but from the explorers’ supplies and equipment. There was general agreement on many issues. Yet the expedition’s organisers, medics and leadership had numerous arguments about the best way to preserve or restore health. These disagreements were the product of both competing medical theories about the cause of disease and the importance of embodied (and somewhat subjective) observations in establishing the safety of foods, atmospheres and environments in this period.
Predicting the scaling relations between the dark matter halo mass and observables from generalised profiles I: Kinematic tracers
Authors: Sullivan A. , Power C. , Bottrell C.
Published: March 2024

We investigate the relationship between a dark matter halo’s mass profile and measures of the velocity dispersion of kinematic tracers within its gravitational potential. By predicting the scaling relation of the halo mass with the aperture velocity dispersion,

$M_\mathrm{vir} - \unicode{x03C3}_\mathrm{ap}$

, we present the expected form and dependence of this halo mass tracer on physical parameters within our analytic halo model: parameterised by the halo’s negative inner logarithmic density slope,

$\unicode{x03B1}$

, its concentration parameter, c, and its velocity anisotropy parameter,

$\unicode{x03B2}$

. For these idealised halos, we obtain a general solution to the Jeans equation, which is projected over the line of sight and averaged within an aperture to form the corresponding aperture velocity dispersion profile. Through dimensional analysis, the

$M_\mathrm{vir} - \unicode{x03C3}_\mathrm{ap}$

scaling relation is devised explicitly in terms of analytical bounds for these aperture velocity dispersion profiles: allowing constraints to be placed on this relation for motivated parameter choices. We predict the

$M_{200} - \unicode{x03C3}_\mathrm{ap}$

and

$M_{500} - \unicode{x03C3}_\mathrm{ap}$

scaling relations, each with an uncertainty of

$60.5\%$

and

$56.2\%$

, respectively. These halo mass estimates are found to be weakly sensitive to the halo’s concentration and mass scale, and most sensitive to the size of the aperture radius in which the aperture velocity dispersion is measured, the maximum value for the halo’s inner slope, and the minimum and maximum values of the velocity anisotropy. Our results show that a halo’s structural and kinematic profiles impose only a minor uncertainty in estimating its mass. Consequently, spectroscopic surveys aimed at constraining the halo mass using kinematic tracers can focus on characterising other, more complex sources of uncertainty and observational systematics.
Spatiotemporal dynamics of subarctic intertidal macrobenthos: going their own ways
Authors: Azovsky Andrey I. , Chikina Margarita V. , Kolobov Mikhail Yu. , Naumov Andrey D. , Udalov Alexei A.
Published: March 2024

Intertidal macrobenthos at the small Chernaya Bight (the White Sea) was surveyed six times during 1993–2018 in order to study spatiotemporal variability. Distributions of sediments and macrophytes were highly variable in both space and time, as were most macrofaunal community attributes. Biomass slightly increased with time, while no long-term trends were found in total abundance, diversity, or functional structure. All community attributes were patchily distributed across the beach, and their patterns were not spatially autocorrelated and poorly associated with sediment properties, but changed considerably from year to year. Temporal changes in the community composition were considerable but less substantial compared with the spatial variations. The overall dynamics of species structure did not show any regular trend-like pattern but formed quasicyclic trajectories in ordination space, with nondirectional, spatially noncorrelated fluctuations around some relatively stable state. Comparison with two other neighbouring intertidal sites, studied annually in 1987–2017, showed that macrofauna at every site had similar average biomasses and common dominant species; however, the communities maintained their specificity in structure and exhibited distinct types of dynamics. In particular, the communities demonstrated different long-term trends in total biomass and diversity and followed their own paths in dynamics, appearing as differently oriented interannual trajectories. Nine most abundant species revealed no significant among-site correlations in abundance, and only two bivalve species showed good intersite agreement in dynamics of biomass. We suggest that local benthic communities are largely influenced by site-specific environmental conditions, resulting in independent and even opposite patterns of dynamics in neighbouring localities.
Effects of residential acaricide treatments on patterns of pathogen coinfection in blacklegged ticks
Authors: Ostfeld Richard S. , Adish Sahar , Mowry Stacy , Bremer William , Duerr Shannon , Evans Andrew S. , Fischhoff Ilya R. , Keating Fiona , Pendleton Jennifer , Pfister Ashley , Teator Marissa , Keesing Felicia
Published: March 2024

Medically important ixodid ticks often carry multiple pathogens, with individual ticks frequently coinfected and capable of transmitting multiple infections to hosts, including humans. Acquisition of multiple zoonotic pathogens by immature blacklegged ticks (Ixodes scapularis) is facilitated when they feed on small mammals, which are the most competent reservoir hosts for Anaplasma phagocytophilum (which causes anaplasmosis in humans), Babesia microti (babesiosis) and Borrelia burgdorferi (Lyme disease). Here, we used data from a large-scale, long-term experiment to ask whether patterns of single and multiple infections in questing nymphal I. scapularis ticks from residential neighbourhoods differed from those predicted by independent assortment of pathogens, and whether patterns of coinfection were affected by residential application of commercial acaricidal products. Quantitative polymerase chain reaction was used for pathogen detection in multiplex reactions. In control neighbourhoods and those treated with a fungus-based biopesticide deployed against host-seeking ticks (Met52), ticks having only single infections of either B. microti or B. burgdorferi were significantly less common than expected, whereas coinfections with these 2 pathogens were significantly more common. However, use of tick control system bait boxes, which kill ticks attempting to feed on small mammals, eliminated the bias towards coinfection. Although aimed at reducing the abundance of host-seeking ticks, control methods directed at ticks attached to small mammals may influence human exposure to coinfected ticks and the probability of exposure to multiple tick-borne infections.
A comprehensive hierarchical comparison of structural connectomes in Major Depressive Disorder cases v. controls in two large population samples
Authors: Thng Gladi , Shen Xueyi , Stolicyn Aleks , Adams Mark J. , Yeung Hon Wah , Batziou Venia , Conole Eleanor L. S. , Buchanan Colin R. , Lawrie Stephen M. , Bastin Mark E. , McIntosh Andrew M. , Deary Ian J. , Tucker-Drob Elliot M. , Cox Simon R. , Smith Keith M. , Romaniuk Liana , Whalley Heather C.
Published: March 2024

Background

The brain can be represented as a network, with nodes as brain regions and edges as region-to-region connections. Nodes with the most connections (hubs) are central to efficient brain function. Current findings on structural differences in Major Depressive Disorder (MDD) identified using network approaches remain inconsistent, potentially due to small sample sizes. It is still uncertain at what level of the connectome hierarchy differences may exist, and whether they are concentrated in hubs, disrupting fundamental brain connectivity.

Methods

We utilized two large cohorts, UK Biobank (UKB, N = 5104) and Generation Scotland (GS, N = 725), to investigate MDD case–control differences in brain network properties. Network analysis was done across four hierarchical levels: (1) global, (2) tier (nodes grouped into four tiers based on degree) and rich club (between-hub connections), (3) nodal, and (4) connection.

Results

In UKB, reductions in network efficiency were observed in MDD cases globally (d = −0.076, pFDR = 0.033), across all tiers (d = −0.069 to −0.079, pFDR = 0.020), and in hubs (d = −0.080 to −0.113, pFDR = 0.013–0.035). No differences in rich club organization and region-to-region connections were identified. The effect sizes and direction for these associations were generally consistent in GS, albeit not significant in our lower-N replication sample.

Conclusion

Our results suggest that the brain's fundamental rich club structure is similar in MDD cases and controls, but subtle topological differences exist across the brain. Consistent with recent large-scale neuroimaging findings, our findings offer a connectomic perspective on a similar scale and support the idea that minimal differences exist between MDD cases and controls.
Assessment of optimal combinations of therapeutic probiotics for depression, anxiety, and stress
Authors: Yang Yafang , Yang Ligang , Wan Min , Pan Da , Sun Guiju , Yang Chao
Published: March 2024

Background

Accumulating data show that probiotics may be beneficial for reducing depressive, anxiety, and stress symptoms. However, the best combinations and species of probiotics have not been identified. The objective of our study was to assess the most effective combinations and components of different probiotics through network meta-analysis.

Method

A systematic search of four databases, PubMed, Web of Science, Cochrane, and Embase, was conducted from inception to 11 January 2024. The GRADE framework was used to assess the quality of evidence contributing to each network estimate.

Results

We deemed 45 trials eligible, these included 4053 participants and 10 types of interventions. The quality of evidence was rated as high or moderate. The NMA revealed that Bifidobacterium exhibited a greater probability of being the optimal probiotic species for improving anxiety symptoms (SMD = −0.80; 95% CI −1.49 to −0.11), followed by Lactobacillus (SMD = −0.49; 95% CI −0.85 to −0.12). In addition, for multiple strains, compared with the other interventions, Lactobacillus + Bifidobacterium (SMD = −0.41; 95% CI −0.73 to −0.10) had a positive effect on depression.

Conclusion

The NMA revealed that Lactobacillus and Bifidobacterium had prominent efficacy in the treatment of individuals with anxiety, depression, and combination of Lactobacillus + Bifidobacterium had a similar effect. With few direct comparisons available between probiotic species, this NMA may be instrumental in shaping the guidelines for probiotic treatment of psychological disorders.
What calibrating variable-value population ethics suggests
Authors: Spears Dean , Stefánsson H. Orri
Published: March 2024

Variable-Value axiologies avoid Parfit’s Repugnant Conclusion while satisfying some weak instances of the Mere Addition principle. We apply calibration methods to two leading members of the family of Variable-Value views conditional upon: first, a very weak instance of Mere Addition and, second, some plausible empirical assumptions about the size and welfare of the intertemporal world population. We find that such facts calibrate these two Variable-Value views to be nearly totalist, and therefore imply conclusions that should seem repugnant to anyone who opposes Total Utilitarianism only due to the Repugnant Conclusion.
Comparing parent-child interaction during wordless book reading, print book reading and imaginative play
Authors: Mathers Sandra J. , Hodgkiss Alex , Kolancali Pinar , Booton Sophie A. , Wang Zhaoyu , Murphy Victoria A.
Published: March 2024

This study investigated differences in adult-child language interactions when parents and their three-to-four-year old children engage in wordless book reading, text-and-picture book reading and a small-world toy play activity. Twenty-two parents recorded themselves completing each activity at home with their child. Parent input was compared across contexts, focusing on interactive and conceptual domains: use of open prompts, expansions or extensions of children’s utterances, and use of decontextualised (abstract) language. Use of linguistic expansions was greater during book reading than toy play. Parents used open questions and added contingent conceptual information more often when reading wordless books than in both other conditions. Findings suggest that wordless books may combine the benefits of open-endedness and linguistic content based around a narrative. Parents’ use of abstract language also varied by condition. This study extends understanding of the role of activity context in shaping children’s language learning environments.