bluuebunny/crossref_metadata_2025 huggingface dataset:
Anti-hyperglyceamic Effects of Psidium guajava LINN Crude Leaf Extracts and Fractions in Alloxan- induced Diabetic Mice.
Authors: Nwabunwanne Eze Uchenna , Anayaochukwu Eze Anthonius , Victor Ugwu Chukwuebuka , Maxwell Onuoha , Mary Ubenyi Stanley
Published: August 2021

In Nigeria, rural inhabitants often resort to herbal remedies and dietary control for the treatment and management of various forms of diabetes mellitus. This study was conducted to provide the rationale for the use of Psidium guajava leaves as a potent traditional antidiabetic remedy. The crude leaf extracts of n-hexane, methanol, and ethyl acetate of Psidium guajava were separately prepared by cold maceration. Then, the ethyl acetate crude extract of Psidium guajava leaves was fractionated by column chromatography to yield ethyl acetate bulked fractions: EF-I (1-75), EF-II (76-150), and EF- III (151-250). The n-hexane, ethyl acetate, and methanol crude leaf extracts and ethyl acetate bulked fractions (EF-I, EF-II, and EF-III) were evaluated for antidiabetic activity in alloxan-induced diabetic mice. The blood sugar levels of treated and untreated alloxan-induced diabetic mice were assayed as indices of antidiabetic effect. The phytochemical constituents of both crude extracts and ethyl acetate fractions of Psidium guajava leaves and the mean lethal dose (LD50) of ethyl acetate crude leaf extract of Psidium guajava were determined. The mean lethal dose (LD50) of ethyl acetate crude leaf extract was calculated to be 1500mg/kg b.w. The results indicated that oral administration of ethyl acetate, n-hexane, methanol crude extract, and ethyl acetate bulked fractions of Psidium guajava leaves at a dose of 100mg/kg b.w on treated groups exhibited much significant[p<0.001, p<0.01and p<0.05]anti- hyperglyceamic effect by ameliorating high blood sugar levels of alloxan-induced diabetic treated mice, while EF-II and EF-III showed non-significant[p>0.05] anti-hyperglyceamic activity for the reduction in blood sugar levels compared with the negative and positive control groups. The anti- diabetic potency of the crude leaf extracts and ethyl acetate fractions were in the order; EC>HC>MC>EF-I>EF-II>EF-III. The results of phytochemical screening of the crude extracts and ethyl acetate bulked fractions showed the presence of tannins, flavonoids, saponins, alkaloids, terpenoids, glycosides, and steroids while reducing sugar was absent. The results from this study give credence to the use of Psidium guajava as an antidiabetic agent in the management of diabetes mellitus.
Cementless Primary or Revision Stem in the First-time Revision Hip Arthroplasty for Aseptic Stem Loosening? A Retrospective Comparative Study.
Authors: Pai Fu-Yuan , Chou Te-Feng Arthur , Ma Hsuan-Hsiao , Chang Wei-Lin , Tsai Shang-Wen , Chen Cheng-Fong , Wu Po-Kuei , Chen Wei-Ming
Published: August 2021

IntroductionThe use of primary or revision stem during the first-time revision total hip arthroplasty(THA) procedure for aseptic stem loosening remains controversial. The aim of this study was to compare the outcome of patients that underwent revision THA with a primary or revision stem.Materials and MethodsWe retrospectively reviewed 78 patients that received first-time revision THA for aseptic stem loosening using primary(N=28) or revision stems(N=50). The bone defects were classified as Paprosky type I or II. The mean follow-up duration was 72.3±34.7 months. The primary outcome domains included surgical complications and implant failures. The secondary outcome domains included medical complications, 30-day and 90-day readmission, and Harris hip score (HHS).ResultsThe use of revision stem was associated with higher incidence of patient having complications (60.0% vs. 32.1%, p=0.018), including intraoperative femur fracture (28.0% vs. 7.1%, p=0.029) and greater trochanter fracture (16.0% vs. 0%, p=0.045), compared with the use of primary stem. The implant survival was comparable in both groups. HHS at the final follow-up was similar.ConclusionWith a lower risk of surgical complication and similar mid-term implant survival, cementless primary stem might be a better alternative to revision stem in the first-time revision THA for aseptic stem loosening.
Probing the Lubrication of Shear-Induced Self-Assembled Layer on Amorphous Carbon Films in Methane Atmosphere
Authors: Chen Lin , Wu Jian , Lu Zhibin , Shang Lunlin , Zhang Guangan , Xue Qunji
Published: August 2021

Demand for reduction in friction and improvement in wear resistance of moving parts propels exploration in frictional origin for amorphous carbon (a-C) film lubricating properties based on the interfacial states. Methane, as an ideal energy carrier and industrial raw material, is one of active gas. Consequently, the relations between the tribological behaviors of a-C film under methane atmosphere and load or interfacial states were discussed based on experimental and theoretical methods. Experimental results illustrated that, as the load increased, tribological system exhibited various interfacial shear strength at a load of zero and pressure dependence of the shear strength for tribological systems. And then the origin was revealed with theoretical calculation and resulted from the distributions of adsorbates across the sliding interface.
Cerebral Small Vessel Disease Phenotype and 5-year Mortality in Asymptomatic Middle-to-old Aged Individuals
Authors: Lee Wei-Ju , Chou Kun-Hsien , Lee Pei-Lin , Peng Li-Ning , Wang Pei-Ning , Lin Ching-Po , Chen Liang-Kung , Chung Chih-Ping
Published: August 2021

The present study aimed to determine whether a recently proposed cerebral small vessel disease (CSVD) classification scheme could differentiate the 5-year all-cause mortality in middle-to-old aged asymptomatic CSVD. Stroke-free and non-demented participants recruited from the community-based I-Lan Longitudinal Aging Study underwent baseline brain magnetic resonance imaging (MRI) between 2011 and 2014 and were followed-up between 2018 and 2019. The study population was classified into control (non-CSVD) and CSVD type 1–4 groups based on MRI markers. We determined the association with mortality using Cox regression models, adjusting for the age, sex, and vascular risk factors. A total of 735 participants were included. During a mean follow-up of 5.7 years, 62 (8.4%) died. There were 335 CSVD type 1 (57.9 ± 5.9 years), 249 type 2 (65.6 ± 8.1 years), 52 type 3 (67.8 ± 9.2 years), and 38 type 4 (64.3 ± 9.0 years). Among the four CSVD types, CSVD type 4 individuals had significantly higher all-cause mortality (adjusted hazard ratio = 3.7, 95% confidence interval = 1.3−10.8) compared to controls. This novel MRI-based CSVD classification scheme was able to identify individuals at risk of mortality at an asymptomatic, early stage of disease and might be applied for future community-based health research and policy.
Extension of the KDO Turbulence/Transition Model to Account for Roughness
Authors: FANG Chunfei , Xu Jinglei
Published: August 2021

Wall roughness significantly influences both laminar-turbulent transition process and fully developed turbulence. This work has developed a wall roughness extension for the KDO turbulence/transition model. The roughness effect is introduced via the modification of the k and νt boundary conditions, i.e., the wall is considered to be raised at an extra height. The equivalent roughness height is linked to the actual roughness height, and the ratio between them is determined by reasoning. With such a roughness extension, the predictions of the KDO RANS model agree well with the measurements of turbulent boundary layer with a sand grain surface, while the KDO transition model yields accurate cross-flow transition predictions of flow past a 6:1 spheroid.
Metadherin (MTDH) Overexpression Significantly Correlates with Advanced Tumor Grade and Stages among Colorectal Cancer Patients
Authors: Sultan Aimen , Sahar Namood-e , Riaz Syeda Kiran , Qadir Javeria , Waqar Shahzad Hussain , Haq Farhan , Khaliq Tanwir , Malik Muhammad Faraz Arshad
Published: August 2021

BackgroundColorectal cancer is the 4th leading cause of cancer related deaths affecting both men and women worldwide. In the present study, any probable role of MTDH mRNA expression in CRC tumorigenesis was explored using both discovery and validation cohorts. Methods and resultsAfter prior ethical and biosafety approvals, tumor tissue samples along with their adjacent controls were collected for this study from Pakistani patients diagnosed with colorectal cancer. RNA was isolated using Trizol reagent, followed by cDNA synthesis. Transcript analysis of MTDH was performed by using qPCR. Moreover, genome-wide expression of MTDH was also determined through micro-array data analysis using BRB- Array Tools software. MTDH expression was significantly high in tumor tissue samples (p<0.05) compared to their respective controls. Likewise, results of microarray analysis also revealed overamplification of MTDH in tumor samples as compared to controls. Expression of MTDH was also found to be positively correlated with KI-67 index (p<0.05) and were observed to be significantly upregulated in advance tumor grade (p< 0.05) and stage (p< 0.05). However, no association of MTDH overexpression with age and gender could be established. ConclusionHence, it can be concluded that MTDH is a core element that plays a pivotal role in colorectal tumorigenesis irrespective of patient’s age and gender. Molecular insight into the tumor microenvironment revealed MTDH as a niche, representing distinctive framework for cancer progression, thus, making it an innovative target strategy for colorectal cancer treatment.
Impact of targeted bundles to reduce the nebulization time gap from prescription to administration among red triaged patients in emergency department: An quality improvement initiative
Authors: sachdeva Seema Sachdeva seema , Kumar Akshay Kumar Akshay , Aggarwal Parveen Aggarwal Parveen
Published: August 2021

BackgroundSevere exacerbation of asthma are potentially life-threatening and therefore require prompt care and frequent management. Important elements of early treatment includes recognition of early signs and symptoms of breathing difficulty and timely prescription and administration of therapeutic agents. A subsequent delay in receiving nebulization during an acute exacerbation of asthma can leads to cardiac arrest and even death. AimTo reduce the gap in administration of nebulization from its prescription time among red triaged patients by 50% from its baseline. Setting and designThis interventional study was conducted among red triaged patients in emergency department of tertiary care hospital, India . Material and MethodsBaseline information was collected during first 4 weeks to find gap in administration of nebulization from its prescription time. Fish bone analysis and process map were laid down to analyse the situation. The intervention using targeted bundles was done via 3 PDSA (PDSA1: indenting the nebulizers, PDSA 2: training of doctors and nurses, PDSA 3; introducing equipment checklist) to reduce the gap . A run chart using time series analysis model was used to compare the pre and post intervention nebulization gap. ResultsTotal 74 patients (30 in pre- intervention, 44 in post intervention) admitted in red triaged area were observed for nebulization gap from prescription to administration. Median time for nebulization gap before intervention was 46.5 minutes which reduced to 15 minutes in post intervention phase. ConclusionThis bundles of targeted interventions was successful to reduce the nebulization gap. Key words: nebulization gap, prescription time, administration time
Phase I Trial of a Multi-Peptide COVID-19 Vaccine for the Induction of SARS-CoV-2 T-Cell Immunity
Authors: Walz Juliane , Heitmann Jonas , Bilich Tatjana , Tandler Claudia , Nelde Annika , Maringer Yacine , Marconato Maddalena , Reusch Julia , Jäger Simon , Denk Monika , Richter Marion , Anton Leonard , Weber Lisa , Roerden Malte , Bauer Jens , Rieth Jonas , Wacker Marcel , Hörber Sebastian , Peter Andreas , Meisner Christoph , Fischer Imma , Löffler Markus , Klein Reinhild , Rammensee Hans-Georg , Salih Helmut
Published: August 2021

T-cell immunity is central for the control of viral infections. CoVac-1 is a peptide-based vaccine candidate, composed of SARS-CoV-2 T-cell epitopes derived from various viral proteins, combined with the toll-like receptor 1/2 agonist XS15 emulsified in MontanideTM ISA51 VG, aiming to induce superior SARS-CoV-2 T-cell immunity to combat COVID-19. We conducted a Phase I open-label trial, including 36 participants aged 18 to 80 years, who received one single subcutaneous CoVAC-1 vaccination. The primary endpoint was safety analyzed until day 56. Immunogenicity in terms of CoVac-1-induced T-cell response was analyzed as main secondary endpoint until day 28. No serious adverse events and no grade 4 adverse events were observed. Expected local granuloma formation was observed in all study subjects, while systemic reactogenicity was absent or mild. SARS-CoV-2-specific T-cell responses targeting multiple vaccine peptides were induced in all study participants, mediated by multifunctional T-helper 1 CD4+ and CD8+ T cells. CoVac-1-induced interferon-γ T-cell responses by far surpassed those detected in COVID-19 convalescents and were unaffected by current SARS-CoV-2 variants of concern (VOC). Together, CoVac-1 showed a favorable safety profile and induced broad, potent, and VOC-independent T-cell responses, supporting the presently ongoing evaluation in a Phase II trial for patients with B-cell/antibody deficiency.

Funded by the Ministry of Science, Research and the Arts Baden-Württemberg, Germany; ClinicalTrials.gov number, NCT04546841.
Clinical Features of Excyclotorsion In The Non-Paretic Eye of Patients With Congenital Unilateral Superior Oblique Palsy
Authors: Cha Eun-Hyang , Ha Suk-Gyu , Suh Youngwoo , Kim Seung-Hyun
Published: August 2021

To investigate preoperative clinical features and postoperative results according to the correspondence between excyclotorsion and the paretic eye in patients with congenital unilateral superior oblique palsy (USOP). A retrospective review of medical charts was performed. The patients were divided into the accordance (preoperative fundus ocular excyclotorsion in the paretic eye) and discordance (preoperative ocular excyclotorsion in the non-paretic eye) groups. The degree of excyclotorsion (scale, 0–4) was measured. Age, sex, hypertropia at the primary position, fixation preference, inferior oblique overaction, and degree of excyclotorsion were measured at each visit. Ninety-eight patients were included in this study. There were 70 (71.4%) and 28 patients (28.6%) in the accordance and discordance groups, respectively. The mean age in the accordance and discordance groups was 9.2 ± 12.7 and 7.5 ± 8.9 years, respectively. Sixteen patients (22.9%) in the accordance group and 12 patients (42.9%) in the discordance group were aged under 2 years (p=0.04). A fixation preference for the paretic eye was observed in two (2.9%) and eight (28.6%) patients in the accordance and discordance groups, respectively (p < 0.01). The accordance group (2.3 ± 0.67) demonstrated a significantly higher degree of excyclotorsion than the discordance group (1.9 ± 0.64) (p = 0.03). The postoperative degree of excyclotorsion in the accordance group (0.14 ± 0.39) was lower than that in the discordance group (0.28 ± 0.71) (p = 0.01). The prevalence of residual postoperative excyclotorsion (>1) in the discordance group was significantly higher (14 patients, 50%) than that in the accordance group (16 patients, 22.9%) (p = 0.01).Twenty-eight percent of the patients with congenital USOP demonstrated excyclotorsion in the non-paretic eye. Preoperative discordance between excyclotorsion and the paretic eye was observed in patients who were under 2 years of age and preferred fixation of the paretic eye. The postoperative degree of excyclotorsion was significantly lower in the accordance group.
Comparison of Prospective and Retrospective Gated 4D Flow Cardiac MR Image Acquisitions in the Carotid Bifurcation
Authors: Hurd Elliott R. , Han Mengjiao , Mendes Jason K. , Hadley J. Rock , Johnson Chris R. , DiBella Edward V.R. , Oshinski John N. , Timmins Lucas
Published: August 2021

The superior temporal coverage of retrospective versus prospective gating in 4D flow cardiac MRI (cMRI) imaging offers advantages in comprehensively evaluating the hemodynamic environment across the complete cardiac cycle; however, retrospective acquisitions may result in temporal smoothing. Thus, the purpose of this study was to evaluate the agreement of 4D flow cMRI-derived bulk flow features and fluid (blood) velocities in the carotid bifurcation using prospective and retrospective gating techniques. Prospective and retrospective ECG-gated three-dimensional (3D) cine phase-contrast cardiac MRI with three-direction velocity encoding (i.e., 4D flow cMRI) data were acquired in ten carotid bifurcations from men (n = 3) and women (n = 2) that were cardiovascular disease-free. Velocity magnitude data were extracted from the fluid domain within the image volumes and evaluated across the entire volume or at defined anatomic planes (common, internal, external carotid arteries). Vector magnitudes were decomposed into components to quantify flow direction and disturbances, including retrograde flow. Flow streamlines encoded for velocity magnitude and velocity profiles were generated. Qualitative and quantitative agreement was observed in bulk flow features and fluid velocity magnitudes derived from either prospective or retrospective ECG-gated 4D flow cMRI. No significant differences in velocity magnitudes or components (υr, υθ, υz) were observed. Importantly, retrospective acquisitions captured increased retrograde flow in the internal carotid artery (i.e., carotid sinus) compared to prospective acquisitions. Prospective and retrospective ECG-gated 4D flow cMRI acquisitions provide comparable evaluations of the hemodynamic environment in the carotid bifurcation. However, the increased temporal coverage of retrospective acquisitions depicts disturbed blood flow patterns not captured by the prospective gating technique.
Autotelic Immersion - Interdependence of the Experience and Autotelic Engagement
Authors: Mikicin Mirosław
Published: August 2021

The aim of this study is to explore the relationships between experienced immersion and autotelic engagement in computer gamers. As the tendency to act for the sake of acting or not, autotelic v/s exotelic engagement makes the gamer more or less susceptible to experiencing immersion. The interdependence of experiencing immersion and the sense of autotelic engagement corresponds to the level of autotelic immersion. Students from different university majors (N=87) participated in the study. They completed 2 questionnaires: The Immersiveness Inventory (ING) and the Engagement Questionnaire (FLOW). The results of this study indicate that the experience of autotelic immersion is enhanced by autotelic engagement, manifesting autotelic cognitive properties during computer game playing. In such cases, Interaction with the environment, Sensory Engagement, Sense of Control, balance between ability level and challenge, intrinsic rewarding, concentrating and focusing, control, feedback, and action awareness merging intertwine with each other. Strong positive correlations of interaction with the virtual environment and sense of control were observed with all dimensions of autotelic engagement: the balance between ability level and challenge, loss of the feeling of self-consciousness, clear goals, intrinsic rewarding, concentrating and focusing, control, and autotelic experience. There is a strong directly proportional relationship between autotelicity and immersion.
Regulation of Follicular Atresia by WIP1-Mediated Apoptosis and Autophagy
Authors: Zhou Su , Xi Yueyue , Chen Yingying , Yan Wei , Wu Meng , Li Milu , Wu Tong , Zhang Jinjin , Shen Wei , Luo Aiyue , Wang Shixuan
Published: August 2021

Female endocrine homeostasis and reproductive success depend on the number and quality of follicles. The follicle is the basic functional unit within mammalian ovaries. Excessive follicular atresia is responsible for the accelerated ovarian aging process. Therefore, exploring the molecular mechanism of follicle development and atresia is essential for protecting ovarian function. In this study, we interrogate the striking correlation between follicular atresia and wild-type p53-induced phosphatase 1 (WIP1) expression in mouse ovaries to understand how WIP1 phosphatase activity regulates follicle development. WIP1 is mainly expressed in granulosa cells of healthy growing follicles, and atretic follicles exhibit significantly weaker WIP1 expression compared with the healthy ones. Our in vivo study indicates that inhibition of WIP1 phosphatase activity causes endocrine disorder, fertility decline and decreased ovarian reserve by triggering excessive follicular atresia through promoting autophagy and apoptosis. By in vitro follicle culture, we determine that inhibiting the WIP1 activity impairs the follicle development, causing more follicular atresia and decreased oocyte quality. Besides, downregulating WIP1 expression in granulosa cells in vitro also promotes apoptosis and autophagy via WIP1-p53 and WIP1-mTOR signal pathway. Our findings from the in vitro and in vivo experiments revealed that appropriate Wip1 expression is required for follicle development. Downregulation of WIP1 expression accelerates follicle atresia via WIP1-p53 and WIP1-mTOR signal pathway related apoptosis and autophagy. It is speculated that moderate up-regulation of WIP1 expression may help delaying the decline of ovarian reserve.
Rapid brain atrophy after COVID-19 encephalitis;Disintegrata Furiosa!
Authors: MARAMATTOM BOBY VARKEY , Rao Tejaswi
Published: August 2021

Objectives: We had a patient with COVID-19 encephalitis who demonstrated striking brain atrophy on 3 MRI scans 60 days apart. We aimed to quantify the volume loss and brain atrophy. This is the first report that quantifies brain atrophy with COVID encephalitis.Methods: A 75 year old partially vaccinated man with COVID encephalitis underwent 3 serial MRI scans. Manual volumetry using PACS software was used to average and quantify brain atrophy between the three scans.Results: In 60 days, our patient had approximately 11.52 % (117 ml) of forebrain atrophy, which corresponded to 78 years of accelerated aging. Cerebellar atrophy of 6.2% (7.7 cc) was also noted. Discussion: We have demonstrated striking brain atrophy with COVID encephalitis. Brain involvement and atrophy or connectome disruptions might contribute to post COVID cognitive impairment. Serial MRI scans after COVID-19 and volumetric analysis may detect post COVID brain atrophy as a cause of cognitive dysfunction.
Covid-19 meets game theory: a proposed experiment
Authors: Stamatopoulos Giorgos
Published: August 2021

Researchers around the globe are searching for a "combo-drug" against Covid-19 by trying to combine various existing drugs. Given a set of such drugs, various algorithms (based, for example, on artificial intelligence) are used to identify the efficacy of different shares of the constituent drugs in the combo-drug. Namely, the relative weight of each drug in a "cooperative" scheme of therapy is sought-after. In the current note we propose to identify these weights using the theory of cooperative games, and in particular the Shapley value, one of the fundamental solution concepts of such games. We derive the weight of each drug by its (normalized) average marginal contribution over all possible "coalitions" of drugs it is used with, where a drug's marginal contribution to a coalition is defined as the increase in the coalition's probability to act against a virus should the drug become its "member". Hence we endow each drug with a consistent measure of significance (which is due to the consistency that Shapley value is associated with). At a theoretical level, we build the cooperative game, and compute the Shapley values, within a milestone model in drug combination theory, the Bliss independence model. At a practical level, the predictions of our game-theoretic model can be tested by using in-vitro experiments, namely experiments that are conducted in test tubes.
LA MOBILITE DU MARCHE DU TRAVAIL : MATERIAU POUR UNE ANALYSE SOCIO-ANTHROPOLOGIQUE DES PROFESSIONS ET CATEGORIES SOCIOPROFESSIONNELLES
Authors:   Maitre-Assistant en Sociologie du Travail et des organisations, Enseignant Chercheur au departement de Sociologie-Anthropologie, Universite dAbomey-Calavi, (Benin)., B. Jaures Kouin
Published: August 2021

What future for the socio-professional categories in an economy and a society in profound mutations?Thats the question posed by the mobility of work and its world, characteristic of excessive globalization. Indeed, the central place that work, in the diversity of its forms, occupies for man and society has been called into question since the end of the last century with the emergence of new codes of work market access and new job categories. We are attending a categorical recomposition of work where some professional groups have disappeared to give birth to others. The sociodemographic variables are strongly correlating the supply of job which is coated in social inequity. By renewing the debate on the job crisis, the economic and social transformations have engendered a deconfiguration of economic activities by inducing a real overhaul of the work world with as a corollary a destructuration of the job structure.This article restores a survey that analyzes the anteriority of socioeconomic mutations to the deconfiguration of socio-professional categories in professional sphere in central and southern Benin. Thus, this paper aims, as a general objective, to examine the impact of changes of the work world in a globalized economy on socio-professional categories. Specifically, it involves, on the one hand, to inventory the various changes that have occurred in socio-professional categories and their effects and, on the other hand, to elucidate the process of the reconfiguration of the socio-professional categories, which will lead us to explain the configuration of the new nomenclature of socio-professional categories.
HAND HYGIENE COMPLIANCE, KNOWLEDGE AND PERCEPTION AMONG HEALTHCARE WORKERS IN A TERTIARY CARE CENTER IN SOUTH INDIA
Authors:   Department of Microbiology, Gandhi Medical College and Hospital, Secunderabad,Telangana, India., Swetha G. , Shailaja V.V. ,   Department of Microbiology, Gandhi Medical College and Hospital, Secunderabad,Telangana, India., Rajeshwar Rao S. ,   Department of Microbiology, Gandhi Medical College and Hospital, Secunderabad,Telangana, India., Nagamani K. ,   Department of Microbiology, Gandhi Medical College and Hospital, Secunderabad,Telangana, India.
Published: August 2021

Aim and objective of the study: To assess the compliance, knowledge and perception among health care workers regarding hand hygiene by conducting regular surveillance and educational programs. This surveillance program objective is to evaluate the effect of three different educational programs on improving hand hygiene compliance, knowledge and perception among health care workers in a tertiary care center in South India Materials and Methods: It is an observational and knowledge perception study conducted ina tertiary care center, over a period of 6 months (Jan 2018 to June 2018) using WHO tools. Questionnaires were distributed to 180 participants which included Doctors, Nurses, technicians, Residents & Medical students in 5 units of the hospital (3 ICUs and 2 post-operative wards) The study is divided into Pre interventional, Interventional and Post interventional phase. The interventions included.1. Role model training. 2. Lectures with PowerPoint presentations, 3. Posters and charts representing hand hygiene protocols & motivational messages Results: Hand hygiene compliance was observed during 2153 hand hygiene opportunities and knowledge perception was assessed among 180 participants in the pre intervention and 180 participants in the post interventional period. After intervention the Hand hygiene compliance rate significantly improved in two post-operative wards and two ICUs (total four out of five units targeted). In the perception survey improvement in knowledge was observed. Strong smell of alcoholic hand rub was mentioned as a common reason for noncompliance in one ICUs. Some wrong practices like using hand rub over the glove were corrected. Conclusion: The surveillance and training program improved the hand hygiene compliance and knowledge among health care workers in four out of five units intertiary care center. Role model training had the most impact. However consistent and continuous educational and training programs are necessary to further improve and maintain the compliance rates of hand hygiene.
THE MANAGERIAL COMPETENCIES OF THE PRINCIPALS OF STATE ISLAMIC JUNIOR HIGH SCHOOL (MADRASAH TSANAWIYAH) AT LAMPUNG SELATAN REGENCY
Authors:   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., Lestari Sri , Etek Yurnalis ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., Hadiati Eti ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia., a Sugianto ,   Post-Graduate Program of Islamic Education Management Study Program, Raden Intan State Islamic University of Lampung, Indonesia.
Published: August 2021

This research aims to describe the managerial competencies of Madrasah Tsanawiyah principals, which cover the conceptual roles, human relations, teaching competencies, technical competencies, and cognitive competencies at South Lampung Regency. The researchers applied the descriptive qualitative approach. The data was collected using three techniques: observation, interviews, and documentation. Then, the data were analyzed within two stages: individual case data analysis and cross-case data analysis. The sources of data for this research were the principals, vice-principals, teachers, and employees. The results of this study indicate that, first, in conceptual competencies, madrasah principals can develop various levels of planning, develop madrasah organizations according to the needs, lead the madrasah to optimize resource utilization, have the right strategy to improve the performance of education personnel and create a conducive madrasah climate. Second, the human relations competencies of the principals of madrasah include planning activities with teachers and implementing the program, organizing teacher activities, directing the implementation of actions to achieve organizational goals, and involving teachers in decision making. Third, in terms of directing the performance of activities to achieve organizational goals, the principals apply the teachers in decision making. Third, in terms of directing actions to achieve organizational goals, the principles involve teachers in decision making. Third, in terms of teaching competencies, the principals possess numerous competencies, such as mastery of the latest learning materials. Fourth, in terms of technical competencies, the principals possess unique knowledge in utilizing facilities and infrastructure. Fifth, the principals have good cognitive as evidenced by their vision and mission, goals, and work programs.
EMPLOYEES ATTITUDE TOWARDS STRESS AND ABSENTEEISM DURING COVID-19 CRISIS IN INDIAN HEALTHCARE INDUSTRY
Authors: M.P. Ashika , Ghosh Nitu , Tabassum Fazeelath
Published: August 2021

The recent Covid-19 pandemic has created shockwaves across the globe and caused mental stress and depression leading to significant impact on an employees personal and professional life. Stress has profound impact on employees job performance, morale, job-satisfaction, behaviour, commitment and long-term productivity. Its malicious impact on employee wellbeing, job conduct and absenteeism cannot be ignored.The covid-19 crisis has imposed myriad of challenges on the healthcare professionals and stress levels have invariably soared, leading to depression, absenteeism, attrition, illness and lower morale to tackle the daily challenges in the healthcare industry. Thus, it becomes mandatory to focus on employees mental health, their attitude towards stress and absenteeism, especially during the crisis. The study attempts to understand the impact of work pressure of health-care workers during current pandemic as they have suffered maximumwork-stress due to overtime, workload and distressful work environment, leading to low job morale and absenteeism. The research design adopted is empirical involving a survey conducted on 108 healthcare workers through stratified sampling technique in sub-groups such as doctors, nurses, and frontline workers of private and government hospitals in the IT capital of India, Bangalore. The data was evaluated using descriptive analysis, regression test, correlation test, ANOVA, Chi square test through SPSS software.Findings show that the stress level among the employee in health-care sector leads to absenteeism and it has been particularly high during the current pandemic. Thus, healthcare sector should focus on such HR interventions that de-stress these employees and improve their morale to reduce absenteeism.
SUPPRESSION TO PROTEST: A JOURNEY OF STRUGGLE OF A DALIT WOMAN IN BABURAO BAGULS NOVEL SOOD
Authors:   Associate Professor and Head, Department of English, RNC Arts, JDB Commerce & NSC Science College, Nasik., S. Baviskar Ghansham
Published: August 2021

Gender violence in any form is a punishable crime in India but still it is prevailing in society. Indian constitution safeguards womens rights and guarantees them equal status. Despite the strong measures taken by the constitution makers, the loopholes in the entire system of the law implementing authority and the government machineries do not act responsible and consider the atrocities on women seriously.The largenumber of atrocity cases registered in the police station and pending in the courts makes it clear.Though Hindu society worships women and regards themgoddesses,they areperceivedsexual beings, play things, commodities and mens possession in reality.This paper is an attempt to present this reality and highlight the plight of women in caste gender-based society that Baburao Bagul projects in his Marathi novel, Sood. Janki, the protagonistis a victim of gender violence perpetuated in the caste prejudiced society. Her rebel against the caste and gender discrimination proves to be a milestone in her struggles with the upper caste mentalities those ones who subjugate and oppress women. Her voice is the voice of entire Dalit community that that she raises to assert her resistance for asserting the identities of entire community and demands for a more open and equal egalitarian society for the welfare of entire humanity on this beautiful planet that has already been turned into a hell by the conformist religious ideologies of the priests.
FERTILITY AND ABORTION RATES FOLLOWINGHYSTEROSCOPIC RESECTION OF UTERINE SEPTA
Authors: Abdullah Mostafa , Mahmoud Elsayed
Published: August 2021

Objectives: the presented work studied the effect of uterine septum resection in patients with short and long septa on obstetric outcomes specially the abortion rates and preterm deliveries Subjects and methods: 100 hundred patients known to have uterine septum had been recruited to a private clinic in Benha city â€“Egypt and classified into two groups according to the length of septum, group A with short septum<2.5cmand groupB with long septum >2.5 cm, all patients subjected to hysterosopic resection of septa after counseling and signed informed consent. Results: The infertility rate was significantly lower in group b after surgery (39.47% vs 10.53%, Pâ€Š=â€Š.006). However, no significant difference was observed in the infertility rate between groups A and B. There were no significant differences in pregnancy rate, and preterm live births rate among the 2 groups (Pâ€Š>.05 for all). In Group A the change is only in the rate of term and preterm which was significant but abortion rate didnt differ, this was the group of the smalls septum <2.5cm.Significant change occurred in the rate of abortion in group b (25 before resection dropped to 10 after with p value of 0.001 a high significant difference also there were a significant change in all other items including the pregnancy rate and term pregnancy (pregnancy rate elevated from 35 cases to 40 cases with p value 0.01 also the rate of term pregnancy highly increased from25 cases before septum resection to 38 cases after resection with p value 0.007 Conclusion: large uterine septum >2.5cm resection associated with increase in fertility and decreased rates of abortions.
POTENTIAL FOR PRODUCING STANDARD COMPOST FROM BEEF CATTLE AND CORN WASTES
Authors:   Agro-Industrial Engineering Study Program, Graduate School, IPB University, Bogor.16880, Indonesia., Paramuji Muji ,   Department of Agricultural Product Technology,Islamic University of North Sumatra, Medan., a Suprihatin ,   Department of Agro-Industrial Technology, IPB University, Bogor.16880, Indonesia., Candra Sunarti Titi ,   Department of Agro-Industrial Technology, IPB University, Bogor.16880, Indonesia., b Sukardi ,   Department of Agro-Industrial Technology, IPB University, Bogor.16880, Indonesia.
Published: August 2021

The success of the corn agro-industry is greatly influenced by fertilizeravailability. A notable effort to support that situation is to increase compost production through the utilization and processing of beef cattle and corn wastes. Thisresearch proposed to produce compost from the utilization of beef cattle and corn wastes by following the Indonesian National Standard (SNI). The composting process was carried out by preparing several materials consisting of beef cattle manure (BCM), wet/dry stover (WS/DS), and EM4 solution. These materials were fermented anaerobically, then checked and stirred every three days.The fermentation was stopped after 40 days. This study used a Randomized Block Design (RBD) consisting of five levels of compost materials treatments, namely P0, P1, P2, P3, and P4, with three replications. The parameters observed were the characteristics of cattle and corn waste, the physical feature of the compost, and the nutrient content of the compost (yield, water content, pH, P2O5, K2O, organic C, total N, and C/N ratio). P2 treatment (BCM:WS:DS:EM4 =1:2:1:1) produced compost with the best characteristics, namely blackish brown color and crumbly with slightly sour aroma. The yield obtained was 32.95%, water content was 10.08%, pH was 5.59, P2O5was 0.50%, K2O 1.26%, organic C was 52.34%, total N was 1.34% and C/N ratio was 39.06. These characteristics are by following under the SNI cheap, practical in manufacture and application in the field, and environmentally friendly.
SLUDGE CHARACTERIZATION OF KHARTOUM PETROLEUM REFINING WASTEWATER TREATMENT PLANT- KHARTOUM-SUDAN
Authors:   Dept. of Environmental Health -College of Health Sciences-Jumeira University-Dubai- UAE., Haroun Mahdi , Mohd Altawil Abdelazim ,   Environment, Natural Resources, and Desertification Research Institute (ENDRI), National Center for Research, Khartoum, Sudan., A.M. Osman Gammas ,   Sudan Academy of Sciences, Khartoum, Sudan., Elrashid Diab Eiman ,   Environment, Natural Resources, and Desertification Research Institute (ENDRI), National Center for Research, Khartoum, Sudan., Khalid Tisser ,   Environment, Natural Resources, and Desertification Research Institute (ENDRI), National Center for Research, Khartoum, Sudan.
Published: August 2021

Clearance of sludge has made a major task in latest periods. In the current study sludge from KPRWTP were investigated concerning physicochemical characteristics & disposal options. Organic content of petroleum sludge & clay soil was 0.23 Â±0.09% and 0.186Â±0.1%, respectively. Metals average concentration: Chromium: 130.95Â±27.32 mg/kg Arsenic: 0.899Â±0.434 mg/kg lead: 47.83Â±21.44 mg/kg Cadmium: 18.33Â±9.04 mg/kg Copper: 209Â±31.18 mg/kg Zinc: 631Â±159.57 mg/kg Nickel: 6.6Â±2.44 mg/kg cobalt: 35.54Â±10.08 mg/kg manganese: 35.54Â±10.08 mg/kg: iron: 501Â±5490.04 mg/kg: titanium: 108.3Â±18.33 mg/kg, and zirconium: 2.54Â±0.246 mg/kg respectively. Sludge was made up of particles to some extent of bigger portion compared to soil (sludge: clay and silt 58.9%, sand 41.1% soil: clay and silt 76%, sand 34%). Core constituents of petroleum sludge were Fe2O3 (38.45%), SiO2 (8.55%), CaO (30.35%), MgO (0.85%). According to standards of (NJDEPSCC) As, Cd, Cu, Pb, Ni, & Zn have significantly lower concentration in sludge comparing guideline for residential and nonresidential utilization. On the other hand, FDEPSCTL showed Cu and Zn were only metals in sludge significantly have high concentration regarding guideline for residential applications only. The study confirmed that heavy metals under investigation were significantly lesser than quantities controlled by (TCLP) of (RCRA), with exception for chromium content.
OCCLUSION INTESTINALE ET GROSSESSE: A PROPOS DUN CAS ET REVUE DE LA LITTERATURE
Authors:   Service De Maternite Au Centre Hospitalier Abderrahim Harouchi De Casablanca., S. Benbouchaib , R. Samhari ,   Service De Maternite Au Centre Hospitalier Abderrahim Harouchi De Casablanca., L. Daif ,   Service De Maternite Au Centre Hospitalier Abderrahim Harouchi De Casablanca., K. Fichtali ,   Service De Maternite Au Centre Hospitalier Abderrahim Harouchi De Casablanca., S. Bouhya ,   Service De Maternite Au Centre Hospitalier Abderrahim Harouchi De Casablanca.
Published: August 2021

Lobstruction intestinale est une complication rare de la grossesse qui peut saccompagner dune mortalite maternelle et fÅ“tale importante. Bien que les signes et symptomes soient similaires a ceux des patientes non gravides, la coexistence dune grossesse complique et retarde le plus souvent le diagnostic de cette affection. Par ailleurs, son traitement comporte quelques particularites et principes que les auteurs rapportent a la lumiÃ¨re de leur experience recente et dune revue de la litterature.
DERIVATION OF A NEW EQUATION FOR CALCULATING THE NUMBER OF ELECTRONS CORRESPONDING TO DIFFERENT VALUES OF THE PRINCIPAL QUANTUM NUMBER
Authors:   Kazakh National Pedagogical University named after Abay, Almaty, Kazakhstan., Akhmetov N.K.
Published: August 2021

This paper deals with a new approach in the formation of periods in the Mendeleevs Periodic Table. Using a newly suggested formula and newly suggested quantum states for the external electron shells of atoms of chemical elements, the author proposed the reconfiguration of periods in the Mendeleevs table. The reducing of the number of periods in the table is assumed, andthe material represented in the paper proves it.The following order of formation of electron layers is suggested: the principle quantum number (n), followed by the quantum state of electrons (first and second) which constitute the electron configurations of subperiods, and only after that - the remaining quantum orbitals (s, d, f, and p).
A QUALITATIVE ANALYSIS OF THE IMPACT OF CULTURAL INERTIA ON STUDYNET/CANVAS USE IN TEACHING AND LEARNING AT A POST-92 UNIVERSITY
Authors: Kakay Sheku
Published: August 2021

Since this line of inquiry is underrepresented in the literature on technology adoption, this study investigates the effect of inertia on technology usage and acceptance in Higher Education institutions. The paper considers the benefits and drawbacks of using technology, especially studynet/canvas and its effect on teaching and learning, as well as why some people embrace technology more slowly than others. The researcher used open-ended questions to assess the views of UH academics and students on a variety of topics, including self-efficacy, for example, self-confidence and self-belief in ones ability to master new technology compatibility instructor effectiveness and facilitating conditions and then analysed their overall influence on teaching and learning, especially in relation to technology use, adoption and acceptance in HEIs. The researcher discovered that users have a high level of self-efficacy, and compatibility has also been suggested to play a significant role in user adoption of the platform.
CHEMICAL AND PHARMACOLOGICAL EVOLUTION OF SOME SYNTHESIZED CHALCONES AND HETROCYCLIC COMPOUNDS
Authors: N Lodhi Geeta , Nayak Amit
Published: August 2021

Pharmaceutical chemistry is focused on quality aspects of medicines and aims to assure fitness for the purpose of medicinal products. With centuries medicinal chemistry had emerged as a magnanimous field of science getting a facelift from the available natural compounds for synthesis of newer and complex molecules possessing medicinal activity while the transit from the earth to a synthetically furnished laboratory. Medicinal chemistry or pharmaceutical chemistry is a discipline at the intersection of chemistry and pharmacology involved with designing, synthesizing and developing pharmaceutical drugs. Chalconesis a generic term given to compounds bearing the 1,3-diarylprop2-en-1-one, which can be functionlized in the propane chain by the presence of olefinic, keto and/or hydroxyl group. Chalcones belongs to the flavonoid family. Chemically chalcones consisted of open chain flavonoids in which the two aromaticrings are joined by a three carbon a,ÃŸ-unsaturated carbonyl system (Dhar, 1981). Microorganisms are a heterogeneous group of several distinct classes of living beings. They were classified under third kingdom, theProstita. Based on differences in cellular organization and biochemistry, the kingdom prostita has been divided into two groups, Prokaryotes and Eukaryotes. Bacteria and blue green algae are prokaryotes while fungi, other algae, slime moulds and protozoa are eukaryotes. Anti-fungal drugs are among the most frequently prescribed preparations because of their fungal activity. They are widely used for the treatment of the fungal diseases such as Candidiasis and Apergillosis. These agents prevent from fungal infection. Anti-oxidant drugs are among the most frequently prescribed preparations prevent Oxidation.
CONCUSSION OF PLAYERUNKNOWNS BATTLE GROUNDS OFSECONDARY SCHOOLSTUDENTS
Authors:   St. Xaviers College of Education (Autonomous), DighaGhat, Patna - 800011, Bihar., Topno Ignatius , Jha Shweta ,   St. Xaviers College of Education (Autonomous), DighaGhat, Patna - 800011, Bihar.
Published: August 2021

Through Education,one has to be better adaptand adjust oneselfin order to change oneself and the society at large. In such stable and sustainable situation one can develop with individuals possessing the best mental and moral qualities. As a result, education enables an individual to face all kinds of challenges in life.The main purpose of the study was to investigate the playingof Player Unknowns Battle Grounds(PubG)of Secondary school students. The objectives of the study wereto study playing of PubG of Secondary school students on the basis of gender, standard of the students, boards of study, type of school and medium of study of secondary school students. The researcher employed survey method by executing Self-constructed and validated tool on 135secondary school students ofPatna in Bihar to assess the objectives of the study.The scholar used mean, Median, S.D. and t testfor the calculation of the collected data. The result revealed that there is no significant difference between the mean scores of male and female, IX and X standard students, CBSE and ICSE students intheir playing of PubG of Secondary School students whereas there is a significant difference between the mean scores of ICSE and BSEB, CBSE and BSEB, Private and Government,English and Hindi mediumsecondary school students in their playing of PubG.