bluuebunny/crossref_metadata_2025 huggingface dataset:
Intraindividual Changes in Rheumatoid Factor and Anti-Cyclic Citrullinated Peptide Antibody Tests in Korean Patients Visiting Local Clinics and Hospitals
Authors: Choi Rihwa , Lee Sang Gon , Lee Eun Hee
Published: February 2022

Limited data are available on test utilization and intraindividual changes in rheumatoid factor (RF) and anti-cyclic citrullinated peptide antibody (anti-CCP) in Korean patients that visit local clinics and hospitals. We retrospectively reviewed longitudinally measured RF and anti-CCP data in Korean patients to investigate the utilization and changes in test results through a laboratory information system. During the 10-year study period, 256,259 specimens were tested for RF. Among them, 32,567 (12.7%) specimens from 31,110 Korean adults had simultaneously measured anti-CCP results. Among them, 1110 (3.6%) subjects had follow-up test results. Among 351 patients with initial positive RF results, 290 (82.6%) had no qualitative change in RF from positive to negative values during follow-up. About 3.8% (29/759) of patients with initial negative results experienced qualitative changes in RF that were positive on follow-up. Among 182 patients with an anti-CCP-positive result at initial measurement, 174 (95.6%) had no qualitative change in anti-CCP from positive to negative or equivocal results during follow-up. About 0.5% (5/928) of patients with initial negative values experienced qualitative changes in anti-CCP to positive values on follow-up. The agreement of qualitative results between RF and anti-CCP was 80.8% (95% confidence interval 78.4–83.1%) at initial measurement and 80.6% (95% confidence interval 79.0–82.1%) overall. The results of this study can help inform utilization of RF and anti-CCP testing for Korean patients visiting local clinics and hospitals.
Conversion of Hemiarthroplasty to Reverse Shoulder Arthroplasty with Humeral Stem Retention
Authors: Reuther Falk , Irlenbusch Ulrich , Kääb Max J. , Kohut Georges
Published: February 2022

The purpose of this study is to evaluate the mid-term clinical results of an ongoing case series on conversion reverse shoulder arthroplasty (RSA) with a modular prosthesis system. We included 17 elderly patients revised for failed hemiarthroplasty after proximal humeral fracture, of which 13 were converted using a modular reverse shoulder prosthesis. Four could not be converted due to overstuffing. For the conversion RSA, we determined the Constant score, American Shoulder and Elbow Surgeons Shoulder Score, visual analogue scale for pain and satisfaction, and range of motion preoperatively, at one year, and at the last follow-up. All measured clinical outcomes improved significantly at both follow-up time points (p < 0.05). The mean duration of surgery was 118.4 min (range: 80.0 to 140.0 min). We observed complications in three patients; these included one late infection and two aseptic stem loosenings. Modular shoulder arthroplasty is a suitable procedure for conversion RSA in elderly patients. All measured postoperative clinical outcomes improved significantly, the complication rate was acceptable, and no prosthesis-related complications occurred. Conversion RSA, although not feasible in every case, is a viable treatment option in the elderly, which can provide successful mid-term results.
Telemedicine for the Diagnosis and Management of Age-Related Macular Degeneration: A Review
Authors: Armstrong Grayson W. , Miller John B.
Published: February 2022

Use of ophthalmic telemedicine for patients with age-related macular degeneration (AMD) has shown remarkable advances over recent years. The recent COVID pandemic accelerated this transition since in-person evaluation of elderly patients at high risk for advanced AMD and severe vision loss were also at higher risk for complications from COVID infection. To date, ophthalmic telemedicine has been successfully used in remote retinal consultation by general ophthalmologists for AMD management, hybrid testing visits with both in-office testing and remote evaluation, as well as early successes in home-based remote monitoring of patients with high-risk AMD. We therefore review the current literature and evidence base related to ophthalmic telemedicine for AMD.
Expression of Iron Metabolism Proteins in Patients with Chronic Heart Failure
Authors: Kozłowska Bogna , Sochanowicz Barbara , Kraj Leszek , Palusińska Małgorzata , Kołsut Piotr , Szymański Łukasz , Lewicki Sławomir , Śmigielski Witold , Kruszewski Marcin , Leszek Przemysław
Published: February 2022

In heart failure, iron deficiency is a common comorbid disease that negatively influences exercise tolerance, number of hospitalizations and mortality rate, and this is why iron iv supplementation is recommended. Little is known about the changes in iron-related proteins in the human HF myocardium. The purpose of this study was to assess iron-related proteins in non-failing (NFH) vs. failing (FH) human myocardium. The study group consisted of 58 explanted FHs; control consisted of 31 NFHs unsuitable for transplantation. Myocardial proteins expressions: divalent metal transporter (DMT-1); L-type calcium channel (L-CH); transferrin receptors (TfR-1/TfR-2); ferritins: heavy (FT-H) or light (FT-L) chain, mitochondrial (FT-MT); ferroportin (FPN), regulatory factors and oxidative stress marker: 4-hydroxynonenal (4-HNE). In FH, the expression in almost all proteins responsible for iron transport: DMT-1, TfR-1, L-CH, except TfR-2, and storage: FT-H/-L/-MT were reduced, with no changes in FPN. Moreover, 4-HNE expression (pg/mg; NFH 10.6 ± 8.4 vs. FH 55.7 ± 33.7; p < 0.0001) in FH was increased. HNE-4 significantly correlated with DMT-1 (r = −0.377, p = 0.036), L-CH (r = −0.571, p = 0.001), FT-H (r = −0.379, p = 0.036), also FPN (r = 0.422, p = 0.018). Reducing iron-gathering proteins and elevated oxidative stress in failing hearts is very unfavorable for myocardiocytes. It should be taken into consideration before treatment with drugs or supplements that elevate free oxygen radicals in the heart.
Lung Congestion Severity in Kidney Transplant Recipients Is Not Affected by Arteriovenous Fistula Function
Authors: Letachowicz Krzysztof , Królicka Anna , Tukiendorf Andrzej , Banasik Mirosław , Kamińska Dorota , Gołębiowski Tomasz , Kuriata-Kordek Magdalena , Madziarska Katarzyna , Mazanowska Oktawia , Krajewska Magdalena
Published: February 2022

Lung ultrasound is a bedside technique for the assessment of pulmonary congestion. The study aims to assess the severity of lung congestion in kidney transplant recipients (KTR) in relation to arteriovenous fistula (AVF) patency. One hundred fifty-seven patients at least 12 months after kidney transplantation were recruited to participate in a cross-sectional study. Apart from routine visits, lung ultrasound at 28 typical points was performed. The patients were assigned to either AVF+ or AVF− groups. The mean number of lung ultrasound B-lines (USBLs) was 5.14 ± 4.96 with no differences between groups: 5.5 ± 5.0 in AVF+ and 4.8 ± 4.9 in AVF−, p = 0.35. The number and proportion of patients with no congestion (0–5 USBLs), mild congestion (6–15 USBLs), and moderate congestion (16–30 USBLs) were as follows: 101 (64.7%), 49 (31.4%), and 6 (3.8%), respectively. In multivariate analysis, only symptoms (OR 5.90; CI 2.43,14.3; p = 0.0001), body mass index (BMI) (OR 1.09; CI 1.03,1.17; p = 0.0046), and serum cholesterol level (OR 0.994; CI 0.998,1.000; p = 0.0452) contributed significantly to the severity of lung congestion. Lung ultrasound is a valuable tool for the evaluation of KTR. Functioning AVF in KTR is not the major factor affecting the severity of pulmonary congestion.
Do Breast Cancer Patients Manage to Participate in an Outdoor, Tailored, Physical Activity Program during Adjuvant Breast Cancer Treatment, Independent of Health and Socio-Demographic Characteristics?
Authors: Stalsberg Ragna , Bertheussen Gro Falkenér , Børset Harriet , Thomsen Simon Nørskov , Husøy Anders , Flote Vidar Gordon , Thune Inger , Lundgren Steinar
Published: February 2022

Exercise could reduce the side-effects of adjuvant breast cancer treatment; however, socio-demographic, health, and intervention conditions may affect patients’ adherence to interventions. This study aimed to examine adherence to a 12-month outdoor post-surgery exercise program among newly diagnosed breast cancer patients during adjuvant treatment, and to identify socio-demographic and health-related predictors. In total, 47 women with invasive breast cancer stage I–II or ductal/lobular carcinoma grade 3 were included pre-surgery and randomized two weeks post-surgery to exercise (2 × 60 min/week). Patient characteristics (body-mass index (BMI), socioeconomic status, comorbidity, physical activity, and maximal oxygen uptake (VO2max)) were recorded pre-surgery. Correlations between adherence and patient characteristics and statistics for between-group differences were performed. The mean age was 54.2 years, mean BMI 27.8 kg/m2, and 54.2% received chemotherapy. Completers had a mean adherence of 81%, independent of season. Withdrawals (23%) occurred after a mean of 6.5 weeks (0–24 weeks), they were suggestively older, had lower socioeconomic status and pre-surgery VO2max, and higher BMI. Household income was significantly lower among withdrawals. There were insignificant correlations between adherence and health conditions. High adherence is achievable in a Nordic outdoor physical exercise program in breast cancer patients during adjuvant treatment, including chemotherapy. Additional studies are needed to clarify follow-up needs in some groups.
Gender-Related Biomechanical Properties of Masseter Muscle among Patients with Self-Assessment of Bruxism: A Comparative Study
Authors: Gałczyńska-Rusin Małgorzata , Pobudek-Radzikowska Małgorzata , Gawriołek Krzysztof , Czajka-Jakubowska Agata
Published: February 2022

It seems extremely important to know the biomechanical properties of the orofacial tissues among patients with increased activity of masticatory muscles, such as bruxism. The aim of this study was to evaluate biomechanical properties of the masseter muscle by using MyotonPRO in adults with probable bruxism and to define gender relations. This study was conducted in the Temporomandibular Disorders Department at Poznan University of Medical Sciences, Poland (June 2021–November 2021) among patients that reported bruxism symptoms The patients underwent a clinical examination, then the biomechanical properties of the masseter muscles were assessed. The MyotonPro measured masseter tone, stiffness and elasticity in 36 patients with a self-assessment of bruxism (18 women and 18 men). Data were collected from relaxed and contracted muscles. In relaxed masseter muscles there were no statistically significant differences between the sexes in muscle tone, stiffness and elasticity. During contraction significant differences were found between the sexes in the tension and the stiffness of the masseter muscles. Moreover, women often experienced headaches in the temporal region and pain in the masseter muscles during palpation. Among patients with a self-assessment of bruxism, accompanying pain was significantly more frequent in women. Male gender was associated with increased muscle tension and stiffness of the contracted masseter muscle.
Differential Expression of miRNA-223 in Coronary In-Stent Restenosis
Authors: Ganjali Shiva , Aghaee-Bakhtiari Seyed Hamid , Reiner Željko , Sahebkar Amirhossein
Published: February 2022

Objective: In-stent restenosis (ISR) is an unfavorable complication that occurs in patients after coronary stenting. Despite the progress with advent of modern DES and new antiplatelet agents, restenosis still hampers PCI short- and long-term results. The aim of this study was to investigate whether circulating miRNA-223, which is associated with HDL particles and involved in cholesterol efflux pathway, have diagnostic capability for determining ISR. Methods: This case–control study comprised 21 ISR and 26 NISR patients. The level of miRNA-223 expression was evaluated by TaqMan Real-Time PCR, quantified by the comparative method (fold change) and normalized to U6 expression. Results: Patients in ISR and NISR groups were not different in terms of demographic, clinical, and biochemical parameters, except that the percentage of patients who had DES was significantly greater in the NISR group (88.9%) in comparison with the ISR group (50%). The serum expression of miRNA-223 in ISR patients was 3.277 ± 0.9 times greater than that in NISR group (p = 0.016). In addition, the results of binary logistic regression demonstrated that the high level of serum miRNA-223 was strongly and positively associated with the ISR risk (OR: 17.818, 95% CI: 1.115–284.623, p = 0.042) after adjustment for age, sex, HDL-C, LDL-C, FBS, and statin consumption. Conclusion: Elevated serum level of miRNA-223 might be helpful in predicting the occurrence of ISR. Further confirmation in future large-scale studies is warranted.
Cyclin D1 Binding Protein 1 Responds to DNA Damage through the ATM–CHK2 Pathway
Authors: Niwa Yusuke , Kamimura Kenya , Ogawa Kohei , Oda Chiyumi , Tanaka Yuto , Horigome Ryoko , Ohtsuka Masato , Miura Hiromi , Fujisawa Koichi , Yamamoto Naoki , Takami Taro , Okuda Shujiro , Ko Masayoshi , Owaki Takashi , Kimura Atsushi , Shibata Osamu , Morita Shinichi , Sakai Norihiro , Abe Hiroyuki , Yokoo Takeshi , Sakamaki Akira , Kamimura Hiroteru , Terai Shuji
Published: February 2022

Cyclin D1 binding protein 1 (CCNDBP1) is considered a tumor suppressor, and when expressed in tumor cells, CCNDBP1 can contribute to the viability of cancer cells by rescuing these cells from chemotherapy-induced DNA damage. Therefore, this study focused on investigating the function of CCNDBP1, which is directly related to the survival of cancer cells by escaping DNA damage and chemoresistance. Hepatocellular carcinoma (HCC) cells and tissues obtained from Ccndbp1 knockout mice were used for the in vitro and in vivo examination of the molecular mechanisms of CCNDBP1 associated with the recovery of cells from DNA damage. Subsequently, gene and protein expression changes associated with the upregulation, downregulation, and irradiation of CCNDBP1 were assessed. The overexpression of CCNDBP1 in HCC cells stimulated cell growth and showed resistance to X-ray-induced DNA damage. Gene expression analysis of CCNDBP1-overexpressed cells and Ccndbp1 knockout mice revealed that Ccndbp1 activated the Atm–Chk2 pathway through the inhibition of Ezh2 expression, accounting for resistance to DNA damage. Our study demonstrated that by inhibiting EZH2, CCNDBP1 contributed to the activation of the ATM–CHK2 pathway to alleviate DNA damage, leading to chemoresistance.
Diagnostic Interval in Extranodal Non-Hodgkin Head and Neck Lymphomas
Authors: Castro Alba Bello , Seoane Juan , Rodríguez Máximo Francisco Fraga , Sampedro Francisco Gude , Romero Javier Seoane , Martin-Biedma Benjamín , Castelo-Baz Pablo
Published: February 2022

The aim of this study is to measure the diagnostic interval (DI) of primary extranodal non-Hodgkin lymphomas (PE-NHL) affecting the head and neck and to discover any associated factors. With this aim, we performed a retrospective observational study in northwestern Spain on patients diagnosed between 1 January 2005 and 1 January 2016. A search was made across the electronic health records of the public health system of this region (SERGAS). DI was used as the dependent variable, and different clinicopathological data of the corresponding patients and tumors were analyzed as exposure variables. PE-NHLs were mostly located in Waldeyer’s ring, and they presented a B phenotype and had a median DI of 65 days. Shorter diagnostic intervals were observed in (1) PE-NHL patients who had comorbidities (p = 0.02), (2) PE-NHL that caused symptoms of dysphagia (p = 0.04), (3) tumors with the highest proliferative activity (Ki67 > 80%) (p = 0.04), and (4) tumors diagnosed in the advanced stages of the disease (p = 0.004). Univariate analysis revealed a significant association between dysphagia and a shorter DI. We conclude that raising awareness about these neoplasms and warning about the presenting symptoms can contribute to earlier diagnoses of these tumors and to better outcomes.
Effects of the Dental Caries Preventive Procedure on the White Spot Lesions during Orthodontic Treatment—An Open Label Randomized Controlled Trial
Authors: Shimpo Yudai , Nomura Yoshiaki , Sekiya Toshiko , Arai Chihiro , Okada Ayako , Sogabe Kaoru , Hanada Nobuhiro , Tomonari Hiroshi
Published: February 2022

(1) Background: The aim of this study was to assess the preventive effect of tooth surface disinfection treatment, in addition to fluoride application, during fixed orthodontic treatment. (2) Methods: An open label randomized control trial for the evaluation of the dental caries preventive procedure was performed for the patients with high caries risk who had been visited at Department of Orthodontics, Tsurumi University Dental Hospital for orthodontics treatment. The follow-up period was six months. White spot lesions (WSLs) were evaluated by quantitative light-induced fluorescence (QLF). Cariogenic bacteria were monitored and evaluated by bacterial culture. In addition, the oral microbiome was evaluated by a next-generation sequence (NGS). (3) Results: By the mixed effect modeling, tooth surface disinfection treatment significantly reduced cariogenic bacteria and all parameters obtained by QLF. (4) Conclusions: Tooth surface disinfection treatment, in addition to PMTC and fluoride application, were effective for dental caries prevention and keeping a healthy microbiome during orthodontic treatment.
Do the Current Guidelines for Heart Failure Diagnosis and Treatment Fit with Clinical Complexity?
Authors: Severino Paolo , D’Amato Andrea , Prosperi Silvia , Dei Cas Alessandra , Mattioli Anna Vittoria , Cevese Antonio , Novo Giuseppina , Prat Maria , Pedrinelli Roberto , Raddino Riccardo , Gallina Sabina , Schena Federico , Poggesi Corrado , Pagliaro Pasquale , Mancone Massimo , Fedele Francesco ,   on behalf of the Italian National Institute for Cardiovascular Research (INRC)
Published: February 2022

Heart failure (HF) is a clinical syndrome defined by specific symptoms and signs due to structural and/or functional heart abnormalities, which lead to inadequate cardiac output and/or increased intraventricular filling pressure. Importantly, HF becomes progressively a multisystemic disease. However, in August 2021, the European Society of Cardiology published the new Guidelines for the diagnosis and treatment of acute and chronic HF, according to which the left ventricular ejection fraction (LVEF) continues to represent the pivotal parameter for HF patients’ evaluation, risk stratification and therapeutic management despite its limitations are well known. Indeed, HF has a complex pathophysiology because it first involves the heart, progressively becoming a multisystemic disease, leading to multiorgan failure and death. In these terms, HF is comparable to cancer. As for cancer, surviving, morbidity and hospitalisation are related not only to the primary neoplastic mass but mainly to the metastatic involvement. In HF, multiorgan involvement has a great impact on prognosis, and multiorgan protective therapies are equally important as conventional cardioprotective therapies. In the light of these considerations, a revision of the HF concept is needed, starting from its definition up to its therapy, to overcome the old and simplistic HF perspective.
Women in Advanced Reproductive Age: Are the Follicular Output Rate, the Follicle-Oocyte Index and the Ovarian Sensitivity Index Predictors of Live Birth in an IVF Cycle?
Authors: Carosso Andrea Roberto , van Eekelen Rik , Revelli Alberto , Canosa Stefano , Mercaldo Noemi , Benedetto Chiara , Gennarelli Gianluca
Published: February 2022

(1) Background: Several researchers have investigated alternative markers related to ovarian responsiveness in order to better predict IVF outcomes, particularly in advanced reproductive-aged women. The follicular output rate (FORT), the follicle-oocyte index (FOI) and the ovarian sensitivity index (OSI) are among the most promising. However, these three metrics have not been investigated as independent predictors of live birth in women of advanced reproductive age; neither have they been compared to the two ‘component’ characteristics that are used to calculate them. (2) Methods: A logistic regression model containing all relevant predictors of ovarian reserve or response was used to evaluate the potential of FORT, FOI and OSI as predictors of live birth. After, the non-linear associations between FORT, FOI and OSI and the probability of live birth were evaluated. Finally, we fitted multiple logistic regression models to compare whether FORT, FOI and OSI were more informative predictors than their components. (3) Results: 590 couples received a total of 740 IVF cycles, after which, 127 (17.5%) obtained a live birth. None of FORT, FOI and OSI showed a strength of association or a p-value even close to female age (odds ratio for live birth (95% confidence interval) 1.00 (0.99–1.01), 1.00 (0.99–1.01), 0.98 (0.88–1.11) and 0.58 (0.48–0.72), respectively). The three models comparing FORT, FOI and OSI with the number of oocytes retrieved, the AFC, the number of preovulatory follicles and the FSH total dose were not more informative. (4) Conclusions: In a population of women of advanced age with unexplained infertility, none of FORT, FOI and OSI were predictive of live birth or more predictive than the two ‘component’ characteristics that were used to calculate them. We suggest clinicians and researchers still use female age as the most reliable predictor of an IVF treatment.
In Patients with Obesity, Are Affective Temperaments Associated with Attrition? An Evaluation during and before the SARS-CoV-2 Pandemic
Authors: Marzola Enrica , Abbate-Daga Giovanni , Scumaci Elena , Ponzo Valentina , Goitre Ilaria , Pellegrini Marianna , D’Eusebio Chiara , Benso Andrea , Belcastro Sara , De Michieli Franco , Crespi Chiara , Broglio Fabio , Ghigo Ezio , Bo Simona
Published: February 2022

Timely data on attrition from weight loss programs for patients with obesity during the SARS-CoV-2 pandemic are lacking, so we aimed to contribute to filling this gap in the literature by comparing attrition during or outside of the SARS-CoV-2 pandemic and its possible association with patients’ affective temperaments, psychopathology, and clinical variables. Two-hundred and eleven outpatients with obesity were recruited and completed the Temperament Evaluation of Memphis, Pisa, and San Diego Auto-questionnaire, Binge Eating Scale, Beck Depression Inventory, and State-Trait Anxiety Inventory. Those who dropped out during the pandemic period were mostly men, with younger age of weight gain, and with a larger waist circumference than completers. Patients with obesity who dropped out outside of the SARS-CoV-2 pandemic showed marked levels of depression, anxiety, binge eating episodes, and higher affective temperaments (but the hyperthymic one) when compared to their counterparts. The cyclothymic temperament slightly increased attrition (OR = 1.13, 95% CI 1.00–1.27 p = 0.05) outside the pandemic, while during the pandemic, male gender (OR = 3.50, 1.04–11.7, p = 0.04) was associated with attrition. These findings suggested that male patients with obesity are at particular risk of drop-out from weight-loss treatment during the SARS-CoV-2 pandemic; contrariwise, outside the pandemic, affective temperaments could be a useful baseline assessment for defining the attrition risk in these patients.
Assessment of Patient Knowledge, Awareness, and Adherence in Heart Failure in a Real-Life Setting: Insights from Data Acquired in Pharmacies
Authors: Kobayashi Masatake , Wilcke Christophe , Girerd Nicolas
Published: February 2022

Background: Patient knowledge is crucial for managing and/or monitoring patients with heart failure (HF). However, “real-life” evidence of knowledge level and awareness in HF is yet to be explored. We assessed unselected HF patients’ knowledge and awareness in a pharmacy setting. Methods: One hundred eight HF patients (mean age [SD], 70 (12) years, 61% men) were studied in pharmacies in the north-east region of France in 2019. All patients were interviewed by their pharmacist to quantify their knowledge in HF, self-assessment of symptoms of congestion, as well as their adherence to HF treatment and guideline-recommended lifestyle. Results: Overall, 40% of patients had not consulted their cardiologist in the past 6 months, and 89% never underwent an HF education program. Regarding HF knowledge, nearly half were unsure whether they had HF (43.5%). Only half of the patients knew how to self-assess HF symptoms (57.4%), while a quarter (25%) were unsure of the purpose of HF medications. Conclusions: In patients with HF assessed in their pharmacies, a majority lacked fundamental knowledge regarding HF, such as self-assessment of congestion, possibly due to a minimal proportion of patients undergoing an HF education program. These results suggest that interventions led by pharmacies may help improve HF education coverage in patients who may have poor access to specialized care.
Organomorphic Carbon Preform Formation Mechanism
Authors: Bogachev Evgeny
Published: February 2022

Looking for ways to increase the structural uniformity of ceramic matrix composites (CMC) resulted in the development of organomorphic composites (C/C, C/SiC, SiC/SiC) where the filament diameter is comparable to the space between the filaments. The structural uniformity of the aforesaid CMCs is determined by their reinforcing preform; however, the mechanism of formation of this structure from polymer fibers remains unclear. This paper discusses an investigation of pressed specimens of the OKSIPAN® nonwoven fabric based on Pyron® polyacrylonitrile (PAN) fibers that were underoxidized as was determined using the electron paramagnetic resonance and microtomography methods. Using electron scanning microscopy, thermomechanical analysis and X-ray tomography, cementation of the preform due to the release and condensation of readily-polymerizing resin-like substances on the fiber surface after pressing at 180 °C was shown to be mainly responsible for retaining the mutual positions occupied by the fibers during pressing. The carbonized residue of the resin-like substances binds the fibers after pyrolysis. The other reason for organomorphic carbon preform consolidation is autohesive interaction of insufficiently cross-linked cores of the PAN fibers, since their thermal oxidation during pyrolysis at up to 1000 °C is hindered by the relatively high density of the compressed polymer preforms. The combination of pressing, thermal stabilization and pyrolysis results in the formation of the organomorphic carbon preform that features a relative density of at least 0.3 and a collection of pores, their normalized diameter ranging between 4 and 40 μm.
An Open-Source Processing Pipeline for Quad-Dominant Mesh Generation for Class-Compliant Ship Structural Analysis
Authors: Grubišić Luka , Lacmanović Domagoj , Palaversa Marin , Prebeg Pero , Tambača Josip
Published: February 2022

We present an algorithm for the fully automatic generation of a class-compliant mesh for ship structural analysis. Our algorithm is implemented as an end-to-end solution. It starts from a description of a geometry and produces a class conforming surface mesh as a result. The algorithm consists of two parts, the automatic geometry refinement and the preconditioned Delaunay frontal quad dominant mesh generator. A geometry is described by a dictionary of elements and it contains points, rods, plates, and openings. A dictionary can contain modeling errors such as unintended overlaps or an unintended loss of connectivity between elements. The main contribution of the paper is the automatic geometry refinement algorithm and the virtual stiffener procedure designed to control the local mesh orientation of a marching front meshing algorithm. The geometry refinement algorithm guarantees that the output dictionary will be such that intersections of the boundary edges of plates are guaranteed to be nodes of any mesh generated by tessellating such geometry. The algorithm is implemented in Python, using the open-source Gmsh system together with the Open CASCADE kernel which is used to implement the automatic geometry refinement. We present several benchmark models from an engineering practice to illustrate our claims as well as to benchmark the efficiency of the various stages of the processing pipeline.
Correlations between Volumetric Capnography and Automated Quantitative Computed Tomography Analysis in Patients with Severe COPD
Authors: Diniz Odair Henrique Gaverio , Pereira Monica Corso , da Silva Silvia Maria Doria , Koenigkam-Santos Marcel , Paschoal Ilma Aparecida , Moreira Marcos Mello
Published: February 2022

Background: In chronic obstructive pulmonary disease (COPD), morphological analysis made by computed tomography (CT) is usually correlated with spirometry as the main functional tool. In this study, quantitative CT analysis (QCT) was compared with volumetric capnography (VCap), alongside spirometry and the 6-min walk test (6MWT). Methods: Twenty-seven patients with severe/very severe COPD were included, compared with nineteen control subjects. All participants performed spirometry and chest high resolution CT scans that were analyzed with fully-automated software. The COPD group was also submitted to VCap and 6MWT. Results: COPD patients (65.07 ± 8.25 years) showed an average FEV1 of 1.2 L (44% of the predicted) and the control group (34.36 ± 8.78 years). VCap × QCT: positive correlations were observed with bronchial wall thickening and negative correlations with diameter and area of the bronchial lumen. Spirometry × QCT: positive correlations were observed between post-BD FVC, FEV1 and FEF 25–75% and diameter and luminal area of the airways and FVC and lung and vascular volumes (emphysema). Negative correlation was observed between post-BD FVC and FEV1 when compared with Pi10 (internal perimeter of 10 mm). 6MWT vs. QCT: negative correlations were observed between the distance covered with relative wall thickness (airways) and vascular volume and peripheral vascular volume (vasculature). Conclusion: Relevant correlations between QCT and pulmonary function variables were found, including the VCap, highlighting the importance of structural analysis in conjunction with a multidimensional functional assessment. This is the first study to correlate airway and parenchyma QCT with VCap.
Impact of Single Amino Acid Substitutions in Parkinsonism-Associated Deglycase-PARK7 and Their Association with Parkinson’s Disease
Authors: Anjum Farah , Joshia Namrata , Mohammad Taj , Shafie Alaa , Alhumaydhi Fahad A. , Aljasir Mohammad A. , Shahwan Moyad J. S. , Abdullaev Bekhzod , Adnan Mohd , Elasbali Abdelbaset Mohamed , Pasupuleti Visweswara Rao , Hassan Md Imtaiyaz
Published: February 2022

Parkinsonism-associated deglycase-PARK7/DJ-1 (PARK7) is a multifunctional protein having significant roles in inflammatory and immune disorders and cell protection against oxidative stress. Mutations in PARK7 may result in the onset and progression of a few neurodegenerative disorders such as Parkinson’s disease. This study has analyzed the non-synonymous single nucleotide polymorphisms (nsSNPs) resulting in single amino acid substitutions in PARK7 to explore its disease-causing variants and their structural dysfunctions. Initially, we retrieved the mutational dataset of PARK7 from the Ensembl database and performed detailed analyses using sequence-based and structure-based approaches. The pathogenicity of the PARK7 was then performed to distinguish the destabilizing/deleterious variants. Aggregation propensity, noncovalent interactions, packing density, and solvent accessible surface area analyses were carried out on the selected pathogenic mutations. The SODA study suggested that mutations in PARK7 result in aggregation, inducing disordered helix and altering the strand propensity. The effect of mutations alters the number of hydrogen bonds and hydrophobic interactions in PARK7, as calculated from the Arpeggio server. The study indicated that the alteration in the hydrophobic contacts and frustration of the protein could alter the stability of the missense variants of the PARK7, which might result in disease progression. This study provides a detailed understanding of the destabilizing effects of single amino acid substitutions in PARK7.
Does Locally Advanced Thyroid Cancer Have Different Features? Results from a Single Academic Center
Authors: Dell’Aquila Marco , Tralongo Pietro , De Ruggieri Giuseppe , Curatolo Mariangela , Revelli Luca , Lombardi Celestino Pio , Pontecorvi Alfredo , Fadda Guido , Larocca Luigi Maria , Raffaelli Marco , Pantanowitz Liron , Rossi Esther Diana
Published: February 2022

Background: Despite the fact that the majority of thyroid cancers are indolent, 15% of patients with well-differentiated carcinoma including papillary thyroid carcinoma (PTC) present with locally advanced thyroid cancer (LATC) at diagnosis. The current study analyzes a cohort of patients with LATC focusing on their risk for local recurrence, distant metastases, and overall survival. Materials and methods: From January 2010 to December 2020, 65 patients with LATC were retrieved, including 42 cases with preoperative cytological samples. BRAFV600E and TERT mutations were performed on both cytology and histopathology specimens in this cohort. Results: Among the 65 cases, 42 (65%) were women. The median age was 60.1 years. Histological diagnoses included 25 (38.4%) with classic PTC and 30 (46.1%) aggressive variants of PTC, mostly tall cell variant (17 cases, 26.1%). Multifocality was seen in 33 cases (50.8%). All patients had nodal metastases. The most common site of extrathyroidal extension was the recurrent laryngeal nerve (69.2%). Staging revealed 21 cases were stage I, none were stage II, 33 were stage III, and 7 were stage IVa and 4 stage IVb. No differences were found between well and poorly/undifferentiated thyroid cancers. Conclusion: These data suggest that locally advanced thyroid cancers, including variants of PTC, exhibit a more aggressive biological course and should accordingly be more assertively managed.
Evidence for Cardiorenal Protection with SGLT-2 Inhibitors and GLP-1 Receptor Agonists in Patients with Diabetic Kidney Disease
Authors: Georgianos Panagiotis I. , Vaios Vasilios , Roumeliotis Stefanos , Leivaditis Konstantinos , Eleftheriadis Theodoros , Liakopoulos Vassilios
Published: February 2022

For almost two decades, the management of patients with type 2 diabetes mellitus (T2DM) and chronic kidney disease (CKD) was based on the optimal glycemic and blood pressure control as well as on the adequate blockade of the renin-angiotensin-system. Over the past few years, sodium-glucose co-transporter 2 (SGLT-2) inhibitors and glucagone-like peptide 1 receptor agonists (GLP1-RAs) were added to our therapeutic armarhatum, offering promise for more effective mitigation of the substantial residual cardiorenal risk of these patients. Large randomized controlled trials (RCTs) designed to demonstrate the cardiovascular safety of SGLT-2 inhibitors and GLP1-RAs showed that these novel anti-diabetic medications improve cardiovascular outcomes in patients with T2DM. RCTs conducted specifically in CKD patients with or without T2DM demonstrated that SGLT-2 inhibitors were also effective in retarding the progression of kidney injury to end-stage kidney disease. The kidney protective effects of GLP1-RA are not yet proven, but RCTs are currently ongoing to investigate this crucial research question. In this article, we review the available clinical-trial evidence supporting the use of SGLT-2 inhibitors and GLP1-RAs for cardiorenal protection in patients with T2DM and CKD. We provide clinical practice recommendations for a personalized approach in the use of these novel therapies, according to the severity of CKD and the presence of other cardiometabolic risk factors.
Traditional Thoughts and Modern Development of the Historical Urban Landscape in China: Lessons Learned from the Example of Pingyao Historical City
Authors: Li Xinpeng , Hou Wei , Liu Meng , Yu Zhenlin
Published: February 2022

In the past 40 years, China has undergone a rapid urbanization process which has led to a significant contradiction between the desire to develop modern urban spaces and the need to protect historic urban sites. Urban construction has brought not only the destruction of the physical space of the historic urban sites, but also the fragmentation of the natural landscape and its structural disconnection to the historic urban landscape. Ancient Chinese planners had their own thoughts regarding urban construction and the specific patterns of the urban landscape. The urban landscape of Chinese historic cities focuses predominantly on the structural relationship to its neighborhood. This paper aims to explore the value and character of the historic landscape of the ancient city, finding the key causes of its decline in the process of urbanization. The World Cultural Heritage city Pingyao is taken as a case study. Firstly, an analysis of its historical spatial structure and urban planning ideas of the ancient city of Pingyao using ancient maps and historical documents is presented. Then, a quantitative analysis of the urban space expansion in Pingyao city from 1989 to 2016 is conducted and its land use structure further analyzed. Additionally, four editions of the urban master plan in Pingyao have comprehensively shown that modern urban construction and planning tend to focus more on urban economic functions and social needs. In contrast, ancient urban planning relied on the spatial connection between urban space and its natural environment to construct a higher urban cultural connotation. As a result, the different development mode between modern urbanization and construction of ancient cities could be the key reason for the decline of spatial structure and landscape fragmentation of historical cities in China. With respect to the experience and thoughts of Pingyao’s ancient urban planning and construction, technical ideas and suggestions are put forward as reference in future spatial planning for Pingyao’s urban development and cultural protection. Our findings have been incorporated into the relevant sections of the spatial planning of Pingyao.
Synthesis and Antimicrobial Evaluation of 2-(6-Imidazo[1,2-a]pyridin-2-yl-5-methyl-2,4-dioxo-3-phenyl-3,4-dihydrothieno[2,3-d]pyrimidin-1(2H)-yl)-N-arylacetamide Derivatives
Authors: Vlasov Sergiy V. , Severina Hanna I. , Borysov Oleksandr V. , Krolenko Konstantin Yu. , Shynkarenko Pavlo E. , Saidov Narzullo B. , Vlasov Vitaliy S. , Georgiyants Victoriya A.
Published: February 2022

6-Heteryl-5-methylthieno[2,3-d]pyrimidin-2,4(1H,3H)-diones are of great interest as the promising objects for the search of antibacterials. In this communication, we obtained 6-(imidazo[1,2-a]pyridin-2-yl)-5-methyl-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione by interaction of 6-(bromoacetyl)-5-methyl-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dione with 2-aminopyridine. The obtained heterocyclic hybrid was further modified by alkylation with 2-chloroarylacetamides. Antimicrobial activity studies for the synthesized compounds using the agar well diffusion method revealed their moderate activity against S. aureus, E. coli and B. subtilis. According to the double dilution assay MIC value results for 6-(imidazo[1,2-a]pyridin-2-yl)-5-methyl-3-phenylthieno[2,3-d]pyrimidine-2,4(1H,3H)-dioneagainst P. aeruginosa was less than the value determined for the reference drug streptomycin. The docking study of the synthesized compounds to the active site of TrmD isolated from P. aeruginosa did not show their effective inhibitory activity.
Unveiling the Hidden Entropy in ZnFe2O4
Authors: Cobos Miguel Angel , Hernando Antonio , Marco José Francisco , Puente-Orench Inés , Jiménez José Antonio , Llorente Irene , García-Escorial Asunción , de la Presa Patricia
Published: February 2022

The antiferromagnetic (AFM) transition of the normal ZnFe2O4 has been intensively investigated with results showing a lack of long-range order, spin frustrations, and a “hidden” entropy in the calorimetric properties for inversion degrees δ ≈ 0 or δ = 0. As δ drastically impacts the magnetic properties, it is logical to question how a δ value slightly different from zero can affect the magnetic properties. In this work, (Zn1-δFeδ)[ZnδFe2-δ]O4 with δ = 0.05 and δ = 0.27 have been investigated with calorimetry at different applied fields. It is shown that a δ value as small as 0.05 may affect 40% of the unit cells, which become locally ferrimagnetic (FiM) and coexists with AFM and spin disordered regions. The spin disorder disappears under an applied field of 1 T. Mossbauer spectroscopy confirms the presence of a volume fraction with a low hyperfine field that can be ascribed to these spin disordered regions. The volume fractions of the three magnetic phases estimated from entropy and hyperfine measurements are roughly coincident and correspond to approximately 1/3 for each of them. The “hidden” entropy is the zero point entropy different from 0. Consequently, the so-called “hidden” entropy can be ascribed to the frustrations of the spins at the interphase between the AFM-FiM phases due to having δ ≈ 0 instead of ideal δ = 0.
Microstructural Evolution and Mechanical Properties of Pure Aluminum upon Multi-Pass Caliber Rolling
Authors: Guo Shulong , Yu Hui , Wang Zhifeng , Yu Wei , Cheng Weili , Huang Lixin , Liu Chunhai , Yin Fuxing , Zhao Weimin , Qin Chunling
Published: February 2022

The paper presents the microstructure and mechanical property of pure aluminum (Al) fabricated by multi-pass caliber rolling at room temperature. The finite element modeling (FEM) simulation was performed to explore the changes in rolling force, effective stress and strain, and temperature under various rolling passes. As the number of rolling passes increased, the overall temperature, effective stress, and strain gradually increased, while the maximum rolling force decreased. In addition, due to the dynamic recrystallization (DRX), the average grain size reduced from 1 mm to 14 µm with the increase in rolling passes. The dislocation density increased and it gradually evolved into the high-angle grain boundaries (HAGBs). Moreover, the initial cubic texture rotated to the brass component and finally changed to a mixture of Cube and Brass types. The highest tensile yield strength (TYS), ultimate tensile strength (UTS) and elongation (El.) of caliber rolled pure Al (116 MPa, 135 MPa, and 17%, respectively) can be achieved after 13 rolling passes, which mainly attributed to grain refinement.
Laser Deposited 18Ni300 Alloy Powder on 1045 Steel: Effect of Passes and Preheating on Microstructure
Authors: Emadinia Omid , Gil Jorge , Amaral Rui , Lopes Cláudia , Rocha Rui , Reis Ana
Published: February 2022

The application of maraging steels such as 18Ni300 alloy is noteworthy for mould industries, applying repair purposes through direct energy deposition process. This objective requires microstructural characterizations and the evaluation of mechanical behaviour such as hardness. The state of substrate material, including the heat-affected zone (HAZ) and the interface between the HAZ and deposited layer, is essential, the formation of hard phases and abrupt transitions. Thus, the influence of the number of deposited layers or the pre-heating condition appears noteworthy. In the current study, microscopy observations did not reveal the presence of any crack in the cross-sections of deposited 18Ni300 alloy powder on AISI 1045 sheet steel; however, pores were observed in deposited layers. Besides, microscopic analyses revealed the achievement of a smooth HAZ in the deposited layers composed of three-layered depositions or that received preheating, confirmed by hardness measurements as well. Dilution effect ensured a metallurgical bonding between depositions and substrate, strongly affected by preheating. The HAZ microstructure, mainly martensitic transformation, distribution of chemical composition, epitaxial growth at the interface, and the size of crystals and grains were affected by preheating or the number of layers. Moreover, the heat propagation and/or dissipation across the deposited layers influenced the dendrite morphology and the texture of grains. The preheating condition provoked the formation of cellular/equiaxed dendrites that was highlighted in the three-layered deposition, increase in dendrite interspace growth.
Rare Earth Group Separation after Extraction Using Sodium Diethyldithiocarbamate/Polyvinyl Chloride from Lamprophyre Dykes Leachate
Authors: Allam Eman M. , Lashen Taysser A. , Abou El-Enein Saeyda A. , Hassanin Mohamed A. , Sakr Ahmed K. , Cheira Mohamed F. , Almuqrin Aljawhara , Hanfi Mohamed Y. , Sayyed M. I.
Published: February 2022

This study presents the first application of sodium diethyldithiocarbamate/polyvinyl chloride (DdTC/PVC) as a novel adsorbent for rare earth element (REE) sorption from leach liquors. DdTC/PVC has higher adsorption properties than other sorbents, the synthesis of DdTC/PVC is more accessible than other resins, and it is considered a more affordable sorbent. The three-liquid-phase extraction technique (TLPE) was applied to separate REEs into light, middle, and heavy rare earth elements as groups. The TLPE is an excellent achievable technique in the separation of REEs. DdTC/PVC was prepared as a sorbent to sorb rare-earth ions in chloride solution. It was described by XRD, SEM, TGA, and FTIR. The factors pH, initial rare-earth ion concentration, contact time, and DdTC/PVC dose were also analyzed. The ideal pH was 5.5, and the ideal equilibration time was found to be 45 min. The rare-earth ion uptake on DdTC/PVC was 156.2 mg/g. The rare-earth ion sorption on DdTC/PVC was fitted to Langmuir and pseudo-2nd-order models. The rare-earth ions’ thermodynamic adsorption was spontaneous and exothermic. In addition, rare-earth ion desorption from the loaded DdTC/PVC was scrutinized using 1 M HCl, 45 min time of contact, and a 1:60 S:L phase ratio. The obtained rare earth oxalate concentrate was utilized after dissolving it in HCl to extract and separate the RE ions into three groups—light (La, Ce, Nd, and Sm), middle (Gd, Ho, and Er), and heavy (Yb, Lu, and Y)—via three-liquid-phase extraction (TLPE). This technique is simple and suitable for extracting REEs.
Kelvin Probe Microscopy Investigation of Poly-Octylthiophene Aggregates
Authors: Bermejo Joaquin , Colchero Jaime , Palacios-Lidon Elisa
Published: February 2022

Conductive polymers have fundamental relevance as well as novel technological applications in the organic optoelectronics field. Their photophysical and transport properties strongly depend on the molecular arrangement, and nanoscale characterization is needed to fully understand the optoelectronic processes taking place in organic devices. In this work, we study the electrostatic properties of poly-3-octylthiophene isolated structures: disordered low-packed polymer chains and crystalline layered lamellar assemblies. We characterize the electronic ground state using Kelvin probe microscopy. This allows us to resolve a rich variety of surface potential regions that emerge over the different polymer structures. These SP regions are correlated with different molecular aggregates.