bluuebunny/crossref_metadata_2025 huggingface dataset:
Legislative Impact on Land Markets in Cities
Authors: Pethe Abhay , Nallathiga Ramakrishna
Published: August 2017

Land has recently been looked upon as having substantial value in the Indian cities, especially in Mumbai. However, the allocation of land is a contested area with conflicting views and experiences. Governments intervene in land allocation through legislations for achieving equity but they do so without understanding the institutional structure and changing political, social and economic order. The Urban Land (Ceiling and Regulation) Act (ULCRA) is a piece of legislation through which Indian government made an attempt to redistribute urban land by limiting private ownership of it and confiscating the surplus. A critical review of its performance in India points to the difficulty of achieving such lofty goals in the complex real world, wherein different players actively use a variety of tactics to protect their interest, and also negotiate the outcome in the event of its repeal. The weak institutional capacity of the government and the changing governance framework render the outcomes detrimental. The experience of Mumbai city presented further points to the fact that the multiple actors thus have evolved their strategies to protect their interests through lobbying, corruption and legal wrangling. The experience of ULCRA, therefore, points to ground-level impediments to implementation of law and varied responses of the actors so as to preserve (or, even enhance) their particular interests. ULCRA also went against the decentralization of urban governance that began after the 74th Constitutional Amendment Act.
The Impact of Subsidies and Charging Facilities on Demand for Electric Vehicles in China
Authors: Ma Shaohui , Gao Pingping , Tan Hui
Published: August 2017

The Chinese government has announced a trial programme to provide for private purchase of new battery-operated electric vehicles (EVs) and for plug-in hybrids in five cities. We investigate the potential impact of these subsidies and charging facilities on demand for EVs, using data from a survey of potential car buyers in China. Building on the understanding of factors and incentives that would likely encourage households to adopt EVs would help to improve policy interventions. Data collection is based on experimental design and stated choice methods through an Internet survey. Choice alternatives include a conventional gasoline, a plug-in hybrid and a pure electrical vehicle. In addition to subsidy and charging facilities, we also investigate the impact of common vehicle attributes such as purchase price, cruising range, refuelling time and the socio-demographic effect. Applying a multinomial logit (MNL) model, we find that subsidies would significantly encourage households to choose a plug-in hybrid or an EV. Compared to pure EVs, people in China are more willing to accept plug-in hybrids at present. Compared to the price factors, charging facilities are less of a concern when households consider the adoption of an EV. Willingness-to-pay and market share simulation are computed based on the estimated parameters for further analysis.
Organizational and Managerial Resources and Quality of Care in French Pediatric Oncology Nursing
Authors: Chevalier Séverine , Lejeune Julien , Fouquereau Evelyne , Coillot Hélène , Gillet Nicolas , Gandemer Virginie , Michon Jean , Colombat Philippe
Published: August 2017

The purpose of this study was to examine the relationships between nurses’ organizational and managerial resources (ie, perceived organizational support and transformational leadership) and their quality of patient care, and second, the mediating role of job satisfaction in these relationships. Participants were 510 nurses from 25 out of 29 French pediatric oncology units. Structural equation modeling results revealed that perceived organizational support and transformational leadership were related to nurses’ perceived quality of care and that job satisfaction acted as a mediator between these 2 antecedents (ie, organizational and managerial determinants) and this outcome (ie, quality of care). Based on these findings, practical suggestions and directions for future research are discussed.
The Transmission of Social Class and World of Work Information in Parent–Adolescent Dyads
Authors: Thompson Mindi N. , Her Pa , Nitzarim Rachel S. , Sampe Maggie , Diestelmann Jacob
Published: August 2017

The process by which information about social class and the world of work is transmitted between parents and adolescents within families was explored via Grounded Theory. Data were gathered from separate individual semistructured interviews with 18 participants (9 parents and 9 adolescents from the same family). The themes that emerged from the data are depicted by the grounded theory and reveal an interconnected storyline through which messages about social class and the world of work are communicated in explicit and implicit ways within parent–adolescent relationships. Within each of these themes, three similar subthemes further delineated the nature of these processes within the parent–adolescent dyads: shared emotional reactions between parents and adolescents, the process by which familial communication occurs within the parent–adolescent dyads, and the ways in which adolescents internalize messages from their parents and initiate their own self-learning. Limitations of this study and directions for future research are discussed.
Creativity in ADHD: Goal-Directed Motivation and Domain Specificity
Authors: Boot Nathalie , Nevicka Barbara , Baas Matthijs
Published: August 2017

Objective: This research aimed to provide explanations for the inconsistent findings regarding creativity in ADHD. Method: In Study 1, we assessed real-world creative achievements and intrinsic motivation during idea generation in adults with ADHD and compared these with controls. In Study 2, we manipulated competition during idea generation to investigate effects on idea originality in adults with ADHD versus controls, and assessed creativity in specific domains. Results: Adults with ADHD reported more real-world creative achievements. We did not observe differences in intrinsic motivation during idea generation between groups, but adults with ADHD generated more original ideas when competing for a bonus. Moreover, adults with ADHD rated themselves as more creative in specific creative domains. Conclusion: Our findings suggest that goal-directed motivation may drive the enhanced real-world creative achievements of people with ADHD. Moreover, people with ADHD may selectively engage and excel in creative domains that fit their skills and preferences.
Innovative Methods in Evaluation
Authors: Lamont Andrea E. , Markle Robert S. , Wright Annie , Abraczinskas Michelle , Siddall James , Wandersman Abraham , Imm Pam , Cook Brittany
Published: August 2017

Traditional methods of evaluation are limited in their ability to answer key questions often of interest to process evaluators, such as heterogeneity in the ways individuals adopt new programs. In this article, we demonstrate how a statistical approach, Latent Class Analysis, can help improve the quality of process evaluations and illustrate its use in an evaluation of an educational technology integration program in a large school district. In this illustration, we were interested in detecting variability in the ways teachers adopted the new program. We defined classes based on a set of innovative teaching strategies associated with educational technology. Results showed five distinct subgroups of teachers, based on level of program adoption. Results also demonstrate that specific school support strategies (professional development and personalized computing devices) facilitated program adoption. These findings can help to inform individualized support for teachers to optimize the ease and quality with which they are able to adopt new skills in the classroom.
Qualitative Comparative Analysis as an Evaluation Tool: Lessons From an Application in Development Cooperation
Authors: Pattyn Valérie , Molenveld Astrid , Befani Barbara
Published: August 2017

Qualitative comparative analysis (QCA) is gaining ground in evaluation circles, but the number of applications is still limited. In this article, we consider the challenges that can emerge during a QCA evaluation by drawing on our experience of conducting one in the field of development cooperation. For each stage of the evaluation process, we systematically discuss the challenges we encountered and suggest solutions on how these can be addressed. We believe that sharing this kind of lessons learned can help evaluators become more familiar with QCA, shedding light on what it is to be expected when considering the application of QCA for an evaluation, at the same time reducing unfounded fears and promoting awareness of traps and requirements. The article can be insightful and potentially inspirational for both commissioners and evaluators.
In Search for Optimal Targets for Intraoperative Fluorescence Imaging of Peritoneal Metastasis From Colorectal Cancer
Authors: Hoogstins Charlotte ES , Weixler Benjamin , Boogerd Leonora SF , Hoppener Diederik J , Prevoo Hendrica AJM , Sier Cornelis FM , Burger Jacobus WA , Verhoef Cornelis , Bhairosingh Shadvhi , Farina Sarasqueta Arantza , Burggraaf Jacobus , Vahrmeijer Alexander L
Published: August 2017

Peritoneal metastasis (PM) occurs in about 10% of patients with colorectal cancer (CRC). Fluorescence imaging can enhance contrast between cancerous and benign tissue, enabling the surgeon to clearly visualize PM during cytoreductive surgery. This study assessed the suitability of different biomarkers as potential targets for tumor-targeted imaging of PM of CRC. Tissue samples from primary tumor and PM from patients with CRC were obtained from the pathology archives and immunohistochemical stainings were performed. Overexpression of the epithelial cell adhesion molecule (EpCAM) and carcinoembryonic antigen (CEA) was seen in 100% of PM samples and the expression was strong in >70% of samples. Tyrosine-kinase Met (C-Met) and folate receptor α overexpression was seen in 20% of PM samples. For successful application of tumor-targeted intraoperative fluorescence imaging of PM, biomarkers need to be identified. We demonstrated that both EpCAM and CEA are suitable targets for fluorescence imaging of PM in patients with CRC.
Profiles of family routines during adolescence associated with profiles of health behaviors in young adulthood
Authors: Abar Caitlin C , Koban Kaitlyn , Farnett Sarah , Mendola Kayla , Clark Gabrielle
Published: August 2017

This study examined associations between profiles of family routines in early adolescence and profiles of health behaviors during young adulthood. In a sample of 4565 individuals, latent transition analysis indicated individuals in a family characterized by low involvement in adolescence were most likely, across classes, to demonstrate a profile characterized by substance use in young adulthood. The high-involvement class during adolescence was least likely to be a substance user but was relatively likely to be in the poor diet and exercise class during young adulthood. Results highlight the utility of examining complex family influences on health using person-centered methods.
Gender differences in the experience of pain dismissal in adolescence
Authors: Igler Eva C , Defenderfer Ellen K , Lang Amy C , Bauer Kathleen , Uihlein Julia , Davies W Hobart
Published: August 2017

This study examined physician-generated pain dismissal experiences in adolescence between males and females. Young adults (ages 18–24, N = 178) with chronic or recurrent pain reported at least one pain dismissal experience in adolescence and answered a series of questions regarding the experience during this time period. Females were significantly more likely to report pain dismissal and a physician as the dismisser. Males were more likely to report that the dismisser expressed hostility toward them, feeling ambivalent regarding the dismissal experience, and a desire to avoid the dismisser. Females were more likely to report a desire to plead for understanding with the dismisser. Results suggest that female adolescents are more likely to report a pain dismissal experience with physicians, raising concerns that adolescent females may receive, or at least perceive, differential treatment for their chronic pain.
Mainstreaming Biodiversity in Development Practice: Can the Concept of PES Deliver?
Authors: Grima Nelson , Ringhofer Lisa , Singh Simron J. , Smetschka Barbara , Lauk Christian
Published: August 2017

Given the intricate link between biodiversity and poverty, this article critically reflects on the role of mainstreaming biodiversity in development policy and practice. In order to better understand the operational challenges ‘on the ground’, we present some of the dominant development frameworks within which development organizations operate, all with a view to better understand how aid ‘thinks’ and ‘works’. The article then examines the concept of Payment for Ecosystem Services (PES) as a potential avenue to mainstream biodiversity into development.
Shape memory alloy sensory particles for damage detection: Experiments, analysis, and design studies
Authors: Bielefeldt Brent R , Hochhalter Jacob D , Hartl Darren J
Published: August 2017

Developing novel techniques for monitoring structural integrity has become an important area of research in the aerospace community. One new technique exploits the stress-induced phase transformation behavior in shape memory alloy particles embedded in a structure. By monitoring changes in the mechanical and/or electromagnetic behavior of such particles, the formation or propagation of fatigue cracks in the vicinity of these particles can be detected. This work demonstrates sensory particle response to local structural damage using finite element modeling for the first time. Using an optimization method to minimize the difference between experimentally measured strain and simulated results, a good approximation of sensory particle properties can be determined and the strong sensory response of the transforming particle demonstrated. To illustrate an application of this method, a multi-scale finite element model of sensory particles embedded in the root rib of an aircraft wing is then considered. In particular, this unique model utilizes substructure modeling to maintain computational efficiency while relating globally applied loads to local structural response, allowing for the consideration of predicted particle response to crack propagation during wing loading. The effect of particle position relative to the crack tip on particle sensory response is assessed. Finally, this work demonstrates how sensory particles can be used to approximate the location of structural damage by interpolating a stress field based on the responses of multiple sensory particles in the vicinity of a propagating crack.
Where and How Does Fitting in Matter? Examining New Students’ Perceived Fit With Their University, Instructors, and Classmates
Authors: Knapp Joshua R. , Masterson Suzanne S. , Kedharnath Uma
Published: August 2017

Researchers routinely find that individuals and organizations are better off when the personal characteristics of members fit with contextual organizational characteristics. Typically, this kind of research examines employees and the work environment. However, the dynamics of fit can be applied broadly, and some researchers have found fit-related theory to be a useful tool for examining students’ relationships with their universities. We build on this body of work by using new students’ perceptions of needs-based and values-based fit with their university, instructors, and classmates to predict both intention to recommend and turnover intention. For the purposes of recruitment and retention, results emphasize the importance of needs-based fit with the university and with classmates.
Patterns of Acute Ischemic Strokes After Carotid Endarterectomy and Therapeutic Implications
Authors: Lareyre Fabien , Raffort Juliette , Weill Caroline , Marsé Claire , Suissa Laurent , Chikande Julien , Hassen-Khodja Réda , Jean-Baptiste Elixène
Published: August 2017

Aim:

Acute ischemic strokes following surgical treatment of carotid stenosis lead to substantial disability and mortality, and vascular mechanisms underlying their development are not fully elucidated. The goal of this study was to analyze the topographic patterns of acute ischemic stroke following carotid endarterectomy (CEA) on diffusion-weighted and perfusion-weighted magnetic resonance imaging (MRI).

Material and Methods:

Data were retrospectively collected from consecutive patients who underwent CEA and developed postoperative acute ischemic stroke. Based on the MRI data sets, the lesion patterns of acute stoke were characterized. Morphology of the circle of Willis, the 3-D time-of-flight (3D-TOF) of the cerebral arteries, and status of the carotid circulation were also analyzed in order to determine the vascular mechanisms involved in stroke development.

Results:

Between January 2008 and May 2015, 821 patients were treated surgically for a symptomatic or asymptomatic carotid stenosis at the University Hospital of Nice. Nineteen (2.3%) patients had an acute ischemic stroke after surgery. Among them, 11 (57.9%) patients had a territorial infarction and 8 (42.1%) patients had an internal watershed infarction, cortical watershed infarction, or mixed border zone infarction. According to imaging data sets, embolic mechanism of stroke was reported for 12 (63.2%) patients, hemodynamic mechanism for 2 (10.5%) patients, and mixed mechanism for 5 (26.3%) patients. An asymmetry on 3D-TOF was observed in 60% and 50% of patients with hemodynamic and mixed stroke and in 25% of patients with embolic stroke. The latter 2 patients with embolic stroke underwent successful mechanical thrombectomy using stent-retriever devices.

Conclusion:

In this cohort, embolic mechanism leading to postoperative stroke was more frequently observed than hemodynamic mechanism. Immediate characterization of the cerebral lesion by postoperative brain MRI is of utmost importance because it may rapidly identify patients eligible for treatments such as mechanical thrombectomy.
Path planning for mobile articulated robots based on the improved A* algorithm
Authors: Xu Yaru , Liu Rong
Published: August 2017

Mobile articulated robots system composed of tractor and multiple articulated trailers is a nonlinear and underactuated system subject to nonholonomic constraints. The significant achievements of path planning for mobile robots with single segment are very difficult to be applied to it directly. For resolving this problem, the kinematics model is established for the system with three segments connected by nonstandard connection type, as well as its trajectory. Equivalent size is introduced that includes two parameters: the distance parameter being the size for enlarging obstacles and the curvature parameter being the minimum turning radius of system. The distance parameter is used to enlarge obstacles in the environment to shrink the system to be a particle. The planning path adopted by the improved A* algorithm can ensure itself as a collision-free and feasible path as long as the maximum path curvature is no larger than the curvature parameter in free space. The comparisons of simulation result show that the improved A* algorithm makes the quality of path optimized and more suitable than A* algorithm under the complex environment.
Kindlin-1 is a key protein in hyperbaric oxygen therapy for the treatment of neuropathic pain
Authors: Zhao Baisong , He Erning , Pan Yongying , Xu Haiping , Song Xingrong
Published: August 2017

Background

Hyperbaric oxygen therapy is increasingly used in adjuvant therapies to treat neuropathic pain. However, the specific targets of hyperbaric oxygen treatment in neuropathic pain remain unclear. Recently, we found that hyperbaric oxygen therapy produces an antinociceptive response via the kindlin-1/wnt-10a signaling pathway in a chronic pain injury model in rats.

Methods

The rats received an intraperitoneal injection of AAV-FERMT1 or an adeno-associated virus control vector 20 days before the chronic constriction injury operation. During five consecutive days of hyperbaric oxygen treatment, mechanical withdrawal threshold and thermal withdrawal latency tests were performed. Then, kindlin-1 expression was examined by real-time polymerase chain reaction and Western blot analysis. Meanwhile, the activation of glial cells and the production of TNF-α, IL-1β, and fractalkine were also determined.

Results

Our findings demonstrated that hyperbaric oxygen therapy inhibited the chronic constriction injury–induced increase in kindlin-1 expression. Furthermore, overexpression of kindlin-1 reversed the antinociceptive effects of hyperbaric oxygen therapy. The observed hyperbaric oxygen–induced reductions in glial cell activation and neuroinflammation, as indicated by the production of TNF-α, IL-1β, and fractalkine, were also prominently diminished in the group with kindlin-1 overexpression.

Conclusions

Our findings demonstrate that kindlin-1 is a key protein in the action of hyperbaric oxygen therapy in the treatment of neuropathic pain. Indeed, interference with kindlin-1 may be a drug target for reducing the neuroinflammatory responses of the glial population in neuropathic pain.
Reversible splenial lesion syndrome (RESLES) coinciding with cerebral venous thrombosis: a report of two cases
Authors: Liu Jingyi , Liu Dacheng , Yang Bo , Yan Jing , Pu Yuehua , Zhang Jing , Wen Miao , Yang Zhonghua , Liu Liping
Published: August 2017

A total of two postpartum women with no noteworthy medical history presented with persistent headache. Brain magnetic resonance imaging (MRI) of both revealed extensive cerebral venous thrombosis, concurrently with abnormal signals of the splenium of the corpus callosum (SCC): The splenium appeared hyperintense on T2-weighted sequences, fluid-attenuated inversion recovery (FLAIR), and diffusion-weighted imaging (DWI) imaging, and hypointense on T1 sequences and apparent diffusion coefficient (ADC) map. The patients were given thrombolytic therapy. Clinically, both patients achieved recovery with no neurologic sequelae, and follow-up MRI revealed complete resolution of the lesion in the SCC at day 36 and day 37 after initial presentation, respectively.
Management of functional dyspepsia: state of the art and emerging therapies
Authors: Yamawaki Hiroshi , Futagami Seiji , Wakabayashi Mako , Sakasegawa Noriko , Agawa Shuhei , Higuchi Kazutoshi , Kodaka Yasuhiro , Iwakiri Katsuhiko
Published: August 2017

Patients with functional dyspepsia, defined in the 2016 Rome IV criteria as bothersome clinical dyspepsia symptoms, experience markedly reduced quality of life. Several etiologies have been associated with the disorder. In the Rome IV criteria, the brain–gut axis was acknowledged as an important factor in the etiology of functional gastrointestinal (GI) disorders. The distinct subgroups of functional dyspepsia, epigastric pain syndrome (EPS) and postprandial distress syndrome (PDS), are treated differently: acid secretion inhibitors are recommended with patients with EPS, whereas prokinetic drugs as mosapride and acotiamide are recommended for patients with PDS. A previous study has reported that proton pump inhibitors (PPIs) and H2-blockers were equally effective in functional dyspepsia. A new drug, acotiamide, a muscarinic antagonist and cholinesterase inhibitor, has been shown to improve gastric motility in rodents and dogs, and to reduce PDS symptoms in patients in double-blind multicenter studies. The pharmacological mechanisms of acotiamide remain unknown; whether acotiamide alters gastric emptying and gastric accommodation in patients with functional dyspepsia remains an open question. Other emerging treatment options include Rikkunshito, a herbal medicine that improves gastric emptying through 5-hydroxytryptamine (5-HT)2B-mediated pharmacological action, and tricyclic antidepressants (TCAs). Different drugs are needed to accommodate the clinical symptoms and etiology in individual patients.
A Case Report of Reconstruction of the Left Superior Vena Cava Using the Right Superior Vena Cava Autograft at Bilateral Bidirectional Superior Cavopulmonary Anastomosis
Authors: Shiraishi Shuichi , Sugimoto Ai , Moon Jiyong , Takahashi Masashi , Tsuchida Masanori
Published: August 2017

The choice of graft material for reconstruction of the vena cava in pediatric patients remains controversial. We successfully treated an eight-month-old female patient with single ventricle physiology and long segment obstruction of the left superior vena cava using the right superior vena cava autograft at the time of bilateral bidirectional superior cavopulmonary anastomosis. Postoperative computed tomography confirmed the patency of the reconstruction.
STEM Pathways: Do Men and Women Differ in Why They Enter and Exit?
Authors: Maltese Adam V. , Cooper Christina S.
Published: August 2017

To remedy the disparity between sexes in science, technology, engineering, and mathematics (STEM) fields, it is important to understand the factors critical to initiating and maintaining STEM interest. To this end, we created and administered a survey to almost 8,000 individuals in and outside of STEM fields. Our results shed light on the various factors that are critical for sparking STEM interest and persisting in STEM fields for each sex as well as the differences in movement in and out of STEM pathways for each. These results reveal that although there is no singular pathway into STEM fields, self-driven interest is a large factor in persistence, especially for males, and females rely more heavily on support from others.
An Exploratory Descriptive Study to Evaluate Florida Nurse Leader Challenges and Opportunities in Nursing Homes Settings
Authors: Sherman Rose O. , Touhy Theris
Published: August 2017

By 2020, more than 25% of the population in Florida will be more than the age of 65 years, and the population more than the age of 85 years is expected to increase by 40%. Among people more than 65 years today, 69% are expected to need some form of long-term care as they age. It is anticipated that Florida’s 680 licensed nursing homes will have challenges keeping pace with the needs. This article presents findings from an exploratory descriptive study designed to examine the leadership challenges and opportunities in nursing home settings today from the perspective of long-term care nurse leaders in the State of Florida. The target population for the study was directors of nursing in the 680 state licensed nursing homes in Florida. The final sample included 183 completed surveys from directors of nursing in 27% of the nursing homes that were surveyed. An exploratory descriptive survey design was used in this research. An online survey with 40 closed-ended questions and 2 open-ended questions was designed by the authors with input from an expert panel of long-term care nurse leaders who served in an advisory capacity. While less than 50% of the directors of nursing in this study were prepared at the baccalaureate level or higher, these leaders have complex roles and shoulder significant responsibilities. They have seen their roles expand into the management of more medically complex patients as their organizations try to adapt to a changing health-care reimbursement environment. Succession planning is a key concern for these aging leaders but only 40% of facilities had succession plans in place. The highest ranked leadership challenges involved issues with recruiting and retaining staff with the right skill sets. A poor image of long-term care nursing has contributed to recruitment and retention challenges.
Conducting Midterm Performance Reviews: An Exercise for Teaching Performance Management
Authors: Bull Schaefer Rebecca A.
Published: August 2017

Although the annual performance review has received much criticism from practitioners and researchers alike, organizations continue to use coaching and/or reviews to maximize employee effectiveness and minimize liabilities. A semester class is a great context to practice skills relating to tracking and reviewing performance. This article describes how management instructors can implement performance reviews as an experiential exercise designed to improve students’ confidence related to receiving performance feedback. During a “Performance Appraisal Week,” instructors conduct individual performance reviews designed to discuss individual students’ class performance and elicit student–teacher feedback. Students experience the emotions of a professional face-to-face review, practice multiple-source and multiple-measure feedback interpretation, engage in performance-related dialogue, and consider plans to meet goals. During a full-class reflection and debrief, students apply concepts and discuss elements of performance management systems, and they build their confidence in how to navigate performance-related feedback discussions.
Utilizing Abdominal Sonography in the Diagnosis of Ascites Caused by Heart Failure: A Patient With Cirrhosis
Authors: Knox Spencer , Madruga Mario , Carlan S. J.
Published: August 2017

Abdominal sonography is the most common imaging method used in the detection of ascites. In the presence of cirrhosis, the most likely etiology of ascites is portal hypertension, secondary to the chronic liver disease. A case study is presented of a male with hepatitis C cirrhosis, with symptoms of ascites, which was confirmed with abdominal sonography. Ascitic fluid obtained by paracentesis confirmed the etiology of the ascites was cardiogenic. Significant improvement was documented after heart failure protocol was implemented. Abdominal sonography can detect the presence of ascites with accuracy but lacks the accuracy to diagnose the precise cause.
One-way wave-equation migration of multiples based on stereographic imaging condition
Authors: Li Zhina , Li Zhenchun , Wang Peng , Zhang Mingqiang
Published: August 2017

Multiples are usually regarded as noise in conventional seismic data processing. However, multiples are also real reflections from structural interfaces in the subsurface. Compared with primaries, multiples usually provide more balanced illumination and contain more structural information because of the smaller reflection angles and longer wavepaths. Instead of multiple suppression, multiple imaging has attracted increasingly more attention in recent years. The most commonly used migration method for multiples is performed by replacing the source wavelet with recorded data and using separated multiples as the receiver record. Then, the image of the multiples is obtained by the application of the crosscorrelation imaging condition, which is widely used in conventional migration. However, during the imaging procedure, events are matched based on their propagation times only. Crosscorrelation of unrelated events leads to heavy crosstalk, and image artifacts are introduced in the image of multiples. To overcome this shortcoming, we have introduced the stereographic imaging condition for the one-way wave-equation migration of multiples. By adding a local-slope constraint (the local slope of the extrapolated wavefields at every position and time), the stereographic imaging condition takes the local spatial coherence of the extrapolated wavefields into account. Events can be matched based not only on the propagating times but also the local slopes. Therefore, crosstalk artifacts caused by the interference of unrelated events can be efficiently suppressed. Furthermore, to improve the computational accuracy and efficiency of our approach, plane-wave destructors are introduced to estimate the reflector slopes. In this way, the need for excessive loops over the local slopes in the [Formula: see text]-[Formula: see text] domain during application of the stereographic imaging condition can be avoided by selecting the local slopes in a proper range. Better migration results of multiples are obtained in numerical tests, which verify the feasibility and effectiveness of our approach.
Source to sink studies between the Shaleitian uplift and surrounding sags: Perspectives on the importance of hinterland relief and catchment area for sediment budget, Western Bohai Bay Basin, China
Authors: Zhu Xiaomin , Li Shunli , Liu Qianghu , Zhang Zili , Xu Changgui , Du Xiaofeng , Li Huiyong , Shi Wenlong
Published: August 2017

Source-to-sink system analysis, a cutting-edge topic in the field of earth science, encompasses the whole system, from erosion and transportation to sediment accumulation on the earth’s surface, and involves multidisciplinary collaboration. This current analysis, based on high-precision 3D seismic data, well logs, and other drilling data, using quantitative characterization of the source-to-sink elements, documents that Archean-Proterozoic migmatitic granite, Cambrian-Ordovician carbonate and clastic rocks, and Mesozoic volcaniclastic rocks are developed in the Shaleitian uplift from south to north across large relief differences (up to 2300 m). The relief and size of the catchment in the source area were calculated by denudation recovery, time-depth conversion and high-resolution interpretation on seismic data. Three types of sediment-transporting channel system and 20 catchment areas ([Formula: see text]) were documented around the edges of the uplift: paleovalley channels, fault-controlled channels, and fault-transfer channels. The Paleogene sink is dominated by near-source coarse-grained depositional systems, with the lithofacies characteristics of low lake level (sand rich), lake transgressive (mud rich), and uplift period (sand rich). Three types of boundary conditions developed in the region of the Shaleitian uplift: fault-related steep-slopes (single or multiple), fault ramps, and slope patterns. The bedrock composition, catchment area, channel systems, and fault-border patterns in the Shaleitian uplift jointly controlled the types and scales of sedimentary sandbodies. The south Shaleitian tectonic zone functioned as a high-efficiency coupling system in which reservoir sandbodies were developed (extensive length distance, with well-sorted and round-grained sediments, but weak physical properties). The coupling system for the southwest and west Shaleitian tectonic zones is subordinate (near source and sand rich, sand and mud interbedded, and weak physical properties). The coupling system of the northeast Shaleitian tectonic zone is lowest in efficiency (relatively mud rich).
An Architecture for Translational Cancer Research As Exemplified by the German Cancer Consortium
Authors: Lablans Martin , Schmidt Esther Erika , Ückert Frank
Published: August 2017

Networking of medical institutions by means of a capable data infrastructure has the potential to open up vast amounts of routine data to translational cancer research. However, the secondary use of information collected independently in several institutions is a challenging task of data integration. In this review, we discuss the requirements and common challenges involved in the establishment of such a platform. We present methods and tools from the field of medical informatics as solutions to semantic and technical heterogeneity, questions of data protection and record linkage, as well as issues of trust and data ownership. We also describe the architecture of an existing cancer research network as an exemplary application of these methods.
Post-Transplantation Cyclophosphamide-Based Haploidentical Transplantation as Alternative to Matched Sibling or Unrelated Donor Transplantation for Hodgkin Lymphoma: A Registry Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation
Authors: Martínez Carmen , Gayoso Jorge , Canals Carmen , Finel Hervé , Peggs Karl , Dominietto Alida , Castagna Luca , Afanasyev Boris , Robinson Stephen , Blaise Didier , Corradini Paolo , Itälä-Remes Maija , Bermúdez Arancha , Forcade Edouard , Russo Domenico , Potter Michael , McQuaker Grant , Yakoub-Agha Ibrahim , Scheid Christof , Bloor Adrian , Montoto Silvia , Dreger Peter , Sureda Anna ,   on behalf of the Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
Published: August 2017

Purpose

To compare the outcome of patients with Hodgkin lymphoma who received post-transplantation cyclophosphamide–based haploidentical (HAPLO) allogeneic hematopoietic cell transplantation with the outcome of patients who received conventional HLA-matched sibling donor (SIB) and HLA-matched unrelated donor (MUD).

Patients and Methods

We retrospectively evaluated 709 adult patients with Hodgkin lymphoma who were registered in the European Society for Blood and Marrow Transplantation database who received HAPLO (n = 98), SIB (n = 338), or MUD (n = 273) transplantation.

Results

Median follow-up of survivors was 29 months. No differences were observed between groups in the incidence of acute graft-versus-host disease (GVHD). HAPLO was associated with a lower risk of chronic GVHD (26%) compared with MUD (41%; P = .04). Cumulative incidence of nonrelapse mortality at 1 year was 17%, 13%, and 21% in HAPLO, SIB, and MUD, respectively, and corresponding 2-year cumulative incidence of relapse or progression was 39%, 49%, and 32%, respectively. On multivariable analysis, relative to SIB, nonrelapse mortality was similar in HAPLO ( P = .26) and higher in MUD ( P = .003), and risk of relapse was lower in both HAPLO ( P = .047) and MUD ( P < .001). Two-year overall survival and progression-free survival were 67% and 43% for HAPLO, 71% and 38% for SIB, and 62% and 45% for MUD, respectively. There were no significant differences in overall survival or progression-free survival between HAPLO and SIB or MUD. The rate of the composite end point of extensive chronic GVHD and relapse-free survival was significantly better for HAPLO (40%) compared with SIB (28%; P = .049) and similar to MUD (38%; P = .59).

Conclusion

Post-transplantation cyclophosphamide–based HAPLO transplantation results in similar survival outcomes compared with SIB and MUD, which confirms its suitability when no conventional donor is available. Our results also suggest that HAPLO results in a lower risk of chronic GVHD than MUD transplantation.
Lecture skills
Authors: Михальская  , Mihal'skaya Anna
Published: August 2017

System of essential elements of lecturing skills is described on the base of modern speech and PR theory necessary for learning new lecturing technologies; exercises and assignments are presented. For doctoral candidates, postgraduate and master students, all public speakers.
Corresponds to the last generation of Federal State Educational Standard for higher education.
Service Systems Analysis Methods and Components: A Systematic Literature Review
Authors: Frost Robert , Lyons Kelly
Published: August 2017

The service system has been proposed as the basic abstraction of service science and, as a result, there has been much interest in the study and analysis of service systems in recent years. This paper presents the results of a systematic literature review of recent literature on service systems through which we characterize recent changes in direction and focus in service system research and identify new emphases and areas of focus. We discuss three approaches to service system analysis: descriptive, prescriptive, and evaluative. We also discuss new research focused on studying the components of service systems. Based on research gaps observed in our review, we identify eight specific opportunities and three broad directions for future research: (1) refocusing attention on a greater diversity of research designs and analytical approaches, (2) leveraging new perspectives to perform more ontological work on system components, and (3) fostering a better understanding of the role of innovation. We present a framework of our key findings, depicting the overarching logic linking research questions, opportunities, and directions.
Benders Decomposition for the Design of a Hub and Shuttle Public Transit System
Authors: Mahéo Arthur , Kilby Philip , Van Hentenryck Pascal
Published: August 2017

The BusPlus project aims at improving the off-peak hours public transit service in Canberra, Australia. To address the difficulty of covering a large geographic area, proposes a hub and shuttle model consisting of a combination of a few high-frequency bus routes between key hubs and a large number of shuttles that bring passengers from their origin to the closest hub and take them from their last bus stop to their destination. This paper focuses on the design of the bus network and proposes an efficient solving method to this multimodal network design problem based on the Benders decomposition method. Starting from a mixed-integer programming (MIP) formulation of the problem, the paper presents a Benders decomposition approach using dedicated solution techniques for solving independent subproblems, Pareto-optimal cuts, cut bundling, and core point update. Computational results on real-world data from Canberra’s public transit system justify the design choices and show that the approach outperforms the MIP formulation by two orders of magnitude. Moreover, the results show that the hub and shuttle model may decrease transit time by a factor of two, while staying within the costs of the existing transit system.
Enormous opportunities
Authors: Dixon's Michael
Published: August 2017

A précis of Dr Michael Dixon's speech to the NHS Alliance conference.
The cost of sickness
Authors: Symon Liz
Published: August 2017

Liz Symon outlines the rules.
Planning for 2014
Authors: Densley Liz
Published: August 2017

Liz Densley offers some tips on getting the practice in shape for the year ahead.
Step on the property ladder
Authors: Mileham Phil
Published: August 2017

Phil Mileham considers the housing market.
A key issue
Authors: Cobley Rachel
Published: August 2017

Rachel Cobley adds up the costs.
Setting up a GP federation
Authors: McKenzie Scott , Taylor Keith
Published: August 2017

Scott McKenzie and Keith Taylor outline the process.
The future of employment law
Authors: Sibbald Janice
Published: August 2017

Janice Sibbald spells out the changes.
A fan of Federation
Authors: Amarant
Published: August 2017

Amarant takes the route to intergalactic peace.
A litte more conversation…
Authors: Baker Chris
Published: August 2017

…a little more action, please. Satisfaction's guaranteed with Chris Baker's fours steps to shaking up your practice profile online
Take the plunge!
Authors: Murphy Matt
Published: August 2017

Matt Murphy says now is the time to take dive into the world of online services and join the growing number of GP practices and patients who have already taken that leap of faith
Break down the barriers
Authors: Jones-Tinsley Lisa
Published: August 2017

For business manager Lisa Jones-Tinsley, ‘minding’ languages is all in a day's work
all sewn up!
Authors: Wood Deborah
Published: August 2017

Accountant Deborah Wood pieces together the essential pattern to forming a federation
Lisa Jones-Tinsley
Authors: Jones-Tinsley Lisa
Published: August 2017

Bevan Healthcare CIC cares for the homeless, refugees and asylum seekers in Bradford. Its business manager reveals why being ‘chief cook and bottle washer’ is vital in a practice that saw its patient base rise by 1,000 in the last year
Blow the house down
Authors: Wells Sheila
Published: August 2017

Building works can pull apart a practice team as tempers fray and relationships falter. Reception manager Sheila Wells dons a hard hat to offer some constructive advice on how best to stop your builders turning into a demolition mob
First port of call
Authors: Rogers Greg
Published: August 2017

A look at how practices are key in helping patients to live with epilepsy
Route planning
Authors: Miles-Jenkins Alison
Published: August 2017

How to drive your team in the right direction so they go that extra mile to give great service
after-school activities
Authors: Bissett Julie
Published: August 2017

Editor Julie Bissett suggests why the practice of ‘handholding’ – so often left behind at the school gates – should be part of every A-star team
Characterization of Emergence of the Coulomb Blockade in a Pearl-Like DNA-AuNP Assembly
Authors: Tapio Kosti , Toppari J. Jussi
Published: August 2017

Due to its superior self-assembly properties and vast functionalization pos-sibilities DNA has long been one of the most promising candidates forfabrication of nanoscale electrical components using molecular buildingblocks. There exist already many demonstrations on optical devices based onorganizing metallic nanoparticles (NP) via DNA self-assembly, but despite thepromises only few DNA based electrical devices or studies have been realizedso far. Here we study the gold NP conjugated and metallized DNA TX-tile-structure, which we recently showed to exhibit the room temperature Coulombblockade, the pre-requisition for a single electron transistor. The properties ofthe obtained Coulomb blockade are further characterized via the differentialconductance measurements at temperatures ranging from 4.2 K to 10.2 K.The results show sharp blockade plateaus with varying threshold voltages,which yields further evidence of a gating effect by background charges. Thisstrongly indicates that the DNA-NP assembly functions as a single electrontransistor. Also, the additional growth of gold NPs and electrodes via chemicalgold deposition process, needed to achieve the Coulomb blockade, is studiedhere in more details, yielding more insight to the process, and thus helping torealize better control of it.
Differential Relationships of Anxiety and Autism Symptoms on Social Skills in Young Boys With Fragile X Syndrome
Authors: Reisinger Debra L. , Roberts Jane E.
Published: August 2017

Social skills are critical for academic, social, and psychological success of children with both typical and atypical development. Boys with fragile X syndrome (FXS) are at high risk for social skill impairments, given intellectual impairments and secondary conditions. The present study examines the impact of adaptive behavior, autism symptoms, and anxiety symptoms to social skills at the composite and subdomain level in boys with FXS across age. This cross-sectional study included boys with FXS (3–14 years) contrasted to age-matched typical control boys. Results revealed that social skills are generally within developmental expectations, with adaptive behavior as the primary predictor. Anxiety and autism symptoms emerged as additive risk factors, particularly in the areas of responsibility and self-control.
Extracellular Distribution of Collagen II and Perifibrillar Adapter Proteins in Healthy and Osteoarthritic Human Knee Joint Cartilage
Authors: Firner Sara , Zaucke Frank , Michael Joern , Dargel Jens , Schiwy-Bochat Karl-Heinz , Heilig Juliane , Rothschild Markus Alexander , Eysel Peer , Brüggemann Gert-Peter , Niehoff Anja
Published: August 2017

Perifibrillar adapter proteins, interconnecting collagen fibrils, and linking the collagen network with the aggrecan matrix seem to play a crucial role in the pathogenesis of osteoarthritis (OA). Therefore, we examined immunohistochemically the extracellular distribution of collagen II and the main perifibrillar adapter proteins—collagen IX, decorin, cartilage oligomeric matrix protein (COMP), and matrilin-3—in human samples of healthy (n=4) and OA (n=42) knee joint cartilage. Histopathology assessment was performed using an OA score. Staining patterns were evaluated in relation to the disease stage. The perifibrillar adapter proteins were uniformly distributed in the upper zones of healthy cartilage. In moderate OA (n=8; score 14.3 ± 4.7), all proteins analyzed were locally absent in the fibrillated area or the superficial and upper mid zone. In advanced OA (n=20; score 18.9 ± 5.3), they were uniformly distributed in these zones and accumulated pericellularly. Perifibrillar adapter proteins are important for the stabilization of the collagen network in the upper zones of healthy cartilage. Their degradation might be a critical event in early OA. In advanced OA, there are indications for an increased synthesis in an attempt to regenerate the lost tissue and to protect the remaining cartilage from further destruction.