bluuebunny/crossref_metadata_2025 huggingface dataset:
Diffusion
Authors: Roy Sunipa , Kumar Ghosh Chandan , Dey Sayan , Kumar Pal Abhijit
Published: July 2023

This chapter introduces the readers to the diffusion process of doping
intrinsic silicon. It discusses Fick’s Law of diffusion in-depth and the different types
of diffusion that may be observed. Towards the latter part of the chapter, the diffusion
process in semiconductors has been discussed in detail, explaining the diffusion-assisted doping process commonly employed for semiconductors, especially silicon.
Ion Implantation
Authors: Roy Sunipa , Kumar Ghosh Chandan , Dey Sayan , Kumar Pal Abhijit
Published: July 2023

This chapter discusses the ion implantation process of silicon processing
technology in depth. The chapter gives an in-depth insight into various aspects of the
ion implantation process and ion-implanted silicon systems commonly encountered
in a silicon process. After reading this chapter, the readers will have a sound
understanding of the ion implantation process and its various aspects.
Biological Importance of Some Functionalized Schiff Base-Metal Complexes
Authors: Thakur Mintu , Biswas Kinkar
Published: July 2023

Schiff base ligands or compounds are useful in modern inorganic chemistry.
Numerous transition metal-based catalysts have been synthesized with Schiff base
scaffolds. The application of such Schiff bases is also found in biological studies.
Herein, we have discussed the various synthetic procedures of diversified Schiff base
compounds and their metal complexes. The biological activity of those complexes has
also been delineated in this chapter with special emphasis. Various metal complexes
[Co(II), Ni(II), Cu(II), Zn(II) and Fe(III)] with different Schiff base compounds
displayed anti-fungal activity. Similarly, anti-viral activity was seen with Co(II) and
Pd(II) metal complexes. Many Schiff base-metal complexes are found, which showed
anti-cancer activity against various carcinoma cells like HpG2, MCF-7, A549,
HCT116, Caco-2 and PC-3. Similarly, the transition metal complexes (generally 1st and
2
nd row) of Schiff bases also exhibited good anti-bacterial activity against various
bacterial strains. The ionic-liquid-tagged Schiff bases have also been found to be good
anti-microbial agents
Probiotics-based Anticancer Immunity In Bladder Cancer
Authors: Sánchez Pellicer Pedro , Navarro López Vicente
Published: July 2023

Bladder cancer accounts for an estimated 500,000 new cases and 200,000
deaths annually. The prevalence of bladder cancer is high, with more than 1.6 million
people affected worldwide. Modern techniques not based on microbiological cultures,
such as Next Generation Sequencing (NGS) of the 16S rRNA gene, have provided
robust evidence that a urinary commensal microbiota exists. Few studies have shown a
detailed analysis of the urinary microbiota in patients with bladder cancer. Therefore,
the nature and role of many relevant bladder bacteria in the initiation and progress of
bladder cancer remain under investigation. This chapter describes the main studies in
this regard, as well as the underlying mechanisms, mainly immune-based. Moreover, if
we talk about bladder cancer and the feasibility of probiotics as an alternative treatment
acting on the microbiota, we must start by mentioning the functionality of the Bacille
Calmette-Guérin (BCG) vaccine. Based on the immunogenic performance of the BCG
vaccine, new therapies with probiotic bacteria were proposed, and in vivo and in vitro
studies were performed with positive results in terms of tumor size reduction and
recurrence reduction. Finally, the potential use of Bifidobacterium as a vector in
specific gene therapy against bladder cancer is described.
Probiotics-based Anticancer Immunity in Pancreatic Cancer
Authors: Mishra Swayambara , Dash Jayalaxmi , Mohapatra Amruta , Sethi Manisha , Senapati Shantibhusan
Published: July 2023

Pancreatic cancer is still one of the malignancies with a very poor prognosis
worldwide. In the recent past, the gut microbiota has been shown to have a role in
pancreatic cancer patients’ survival and response to the therapy. Out of the possible
mechanisms, the role of gut microbiota in shaping the microbial composition of
pancreatic tumor and its effect on intra-tumor immune modulation has emerged as a
potential therapeutic strategy. Modulation of gut microbiota for targeting pancreatic
cancer initiation, progression and therapy could be achieved through different
processes like treatment through faecal microbiota transplantation (FMT), antibiotics,
prebiotics, probiotics, and synbiotics. In the recent past, various clinical and
experimental pieces of evidence have demonstrated the efficacy of probiotics in cancer
prevention, treatment and management. In this chapter, efforts have been directed
towards summarizing the prospects and challenges associated with the use of probiotics
and probiotics-derived products against pancreatic cancer.
Unleashing Community Empowerment through A New Regional Autonomy Concept in the 2024 Elections
Authors: Podger Owen Main
Published: July 2023

Long-term planning in all regions in Indonesia in 2025 provides a powerful opportunity to commit governments to community empowerment, an opportunity dependent on the intention of those who are elected to power in the 2024 elections, and their commitment to stress sustainable economic development in those long-term plans, and the regulations to implement the plan. As the culture of reglomania (gila peraturan) is a key inhibiter of empowerment there is a need to change that culture to one that empowers and directs development of the green economy. This paper identifies problems with legislation, including a failure to identify the public service of creating an ordered environment for community development, including regulations for economic linkages and collaboration while providing for diversity. This leads to a reconsideration of the role of provinces, further consideration of accessibility and management of land, and integrity in government. The paper concludes with changes needed in campaigning in 2024 in order to lay the foundation for medium-term and long-term plans for building community empowerment after the elections, and provides a set of recommendations.
Empowering Rural Communities in Papua: Exploring Village Fund Management Socialization in Tablasupa, Jayapura
Authors: Riani Ida Ayu Purba , Purwadi Marsi Adi , Urip Transna	Putra
Published: July 2023

This study investigates the effectiveness of training and socialization on village fund management in Tablasupa Village, Jayapura Regency, and its impact on participants' understanding of village fund management concepts and regulations. The uniqueness of Tablasupa Village as a case study lies in its rural setting and distinct socio-economic characteristics. By focusing on Tablasupa Village, this research presents a localized perspective on village fund management, emphasizing the need for tailored approaches that consider the specific needs and dynamics of rural areas. Prior to the training, participants had limited knowledge regarding key areas such as the definition of RPJMK (Regional Medium-Term Development Plan), the Village Law, types of village income, reporting of activity/program results, and accountability. However, after the training and discussions, participants showed significant improvement in their ability to answer questions correctly, indicating the effectiveness of the training. The study suggests that the training has practical implications in enhancing participants' understanding of financial management practices and empowering rural communities. However, it is important to consider the limitations of the study, such as its narrow focus on Tablasupa Village and the constraints of time and resources. Therefore, future research should encompass a larger sample size and explore multiple locations to obtain a more comprehensive understanding of village fund management in a broader context.
A THEORETICAL ANALYSIS OF SYSTEM DYNAMICS METHODOLOGY ON INFRASTRUCTURE PROJECTS WITHIN THE ENERGY SECTOR
Authors:   University of South Africa, Takalani Mashamba , Kanakana-Katumba Grace ,   Department of Engineering and the Built Environment, Tshwane University of Technology, Maladzhi Rendani ,   Department of Mechanical and Industrial Engineering, University of South Africa
Published: July 2023

The energy sector is critical to a country's economic and social development. Due to economic growth in South Africa, the state-owned firm has witnessed a demand for power supply over the last 20 years. To alleviate the existing supply restriction, it is now implementing capital expansion build programs. The completion of this project has been delayed. Over the last two decades, there has been a lot of system-based study such as considerable research that uses system dynamics (SD) as an analytical and modelling approach. However, merely limited critical reviews have been conducted to provide understanding of SD application in infrastructure projects. We summarize and analyse current research on SD models in infrastructure construction projects in the energy sector in this study, which is based on a thorough systematic literature review. Preferred Reporting Items for Systematic Reviews and Meta-Analysis (PRISMA) approach was used to conduct a search and only 15 studies out of 130 were found to be relevant. According to the findings of the literature analysis, four main feedback structures from prior SD project dynamics models have been recognized as major trends. Design errors, rework and change management, performance and effectiveness, resource management, and project planning and control are some of the topics covered.
THE INFLUENCING FACTORS IN CLEANER PRODUCTION ADOPTION ON THE ALUMINIUM PROCESSING INDUSTRY
Authors:   Urban and Regional Planning, Universitas Bawijaya, Agustina Devi
Published: July 2023

Cleaner Production (CP) practices comprised environmental strategy perpetually applied in the production, processes, and services to bolster efficiency, safety, and environmental friendliness. Some factors are to be considered to achieve a cleaner production strategy: stakeholders establishment, surveys, utilization, and impact, as well as how the top management devote their practices towards cleaner production. Combining with the mindset of sustainable stocks and resources, this exercise of cleaner production provides advantages of minimum toxic wastes and residues. In this study, we prioritize this practice to be applied in the aluminum industry, of which cleaner production action has not yet been employed. Small and medium businesses now no longer have enough monetary assets to put money into cleaner production practices because they require high-cost investment. This study aimed to determine the factors that have an impact on the application of cleaner production. The method used is regression analysis. The regression analysis results showed that three variables were tested to be significant and had a Root Mean Square Error (RMSE) value of 3.05 which means good. Three variables that affected the implementation of cleaner production include measurement of fuel usage, efforts to improve production process efficiency, and waste reuse by product. From the calculation results, the coefficient of determination (R2) was 0.550 (the influence was quite strong). The results of this study can be used as a recommendation for the government to increase the implementation cleaner production in Jombang Regency.
Közösségi média marketing stratégia elemzése – különböző szinten versenyző kézilabda klubok vizsgálatán keresztül
Authors: Pethő Ákos , Pfau Christa Sára
Published: July 2023

Magyarországon kiemelt figyelmet és támogatottságot élvez a kézilabda, ez nem csupán hazánkra, hanem Európára is igaz, valamint egyre nagyobb teret hódít magának világszerte is a sportág. Az elmúlt két évtized egyik legnagyobb újdonsága minden a közösségi média, ami megreformálta az információ átadással és a hagyományos marketing tevékenységgel kapcsolatos alap stratégiákat. Ezeken a platformokon gyökeresen változtak meg a tartalomgyártás folyamatai, amire minden sportklubnak érdemes figyelmet fordítania, hiszen jelentős előnyökhöz juthatnak mind gazdasági-, marketing-, közösségépítés terén egyaránt, ha képesek jól kommunikálni. Három egymástól eltérő szinten versenyző sportklub került összehasonlításra kvalitatív vizsgálat során a közösségi média marketing stratégia tevékenységüket tekintve, amelyek név szerint a PICK Szeged, a Balatonfüredi KSE – BFKA Balatonfüred és a DEAC kézilabda csapata. Ezen vizsgálati modellnek az alapkoncepciója arra épült fel, hogy a különböző szinteken, különböző sportszakmai célokért küzdő klubcsapatok online marketingkommunikációs tevékenysége miben tér el egymástól, valamint mik azok a fejlődési lehetőségek, szempontok, amivel lehető leghatékonyabban lehet érvényesülni a social média felületeken. A kézilabda klubcsapatok több kutatási kérdésben is egyetértettek, de felfedezhető volt jelentős különbség is egy-egy területen, amiben a közösségi médiáért felelős szakemberek nem értettek egyet, vagy más nézőpontot képviseltek. Eredményeimet tekintve megállapítható, hogy egy sikeres online marketing stratégia mögött mindig komoly előkészületi és tervező munka áll, valamint a tartalomgyártás diverzifikálása kulcsfontosságú a különböző felületeken, mert a platformok fogyasztói közössége is eltérő egymástól.
Component development using Topological Methods
Authors: Szabó Kristóf
Published: July 2023

The article aims to briefly summarize the design aids which can be used nowadays, such as topology optimization and generative design, which are common in integrated CAD systems. A case study is used to present the results and comparisons provided by the previously mentioned methods.
Interobserver Variability in Contouring Hepatocellular Carcinoma at a Tertiary Center
Authors: DE LA PINTA CAROLINA , GARCÍA JUAN DAVID , SEVILLANO DAVID , COLMENARES RAFAEL , GARCÍA LATORRE RAQUEL , GARVÍ MANUEL , PINO VANESA , MURIEL ALFONSO , MARTÍN MERCEDES , FERNÁNDEZ EVA , HERNANZ RAUL , MARTÍN MARGARITA , DOMÍNGUEZ JOSE ANTONIO , MUÑÓZ TERESA , PERNA LUIS CRISTIAN , ALBILLOS AGUSTÍN , SANCHO SONSOLES
Published: July 2023

Background/Aim: The optimal imaging test for delineation of the gross tumor volume (GTV) in hepatocellular carcinoma has not been defined. The hypothesis is that magnetic resonance imaging (MRI) allows for better visualization of the extent of tumor and will optimize the accuracy of tumor delineation for liver stereotactic radiotherapy compared with computed tomography (CT) only. We evaluated the interobserver agreement in GTV of hepatocellular carcinoma in a multicenter panel and compared MRI and CT in GTV delineation. Materials and Methods: After the institutional review boards approved the study, we analyzed anonymous CT and MRI obtained from five patients with hepatocellular carcinoma. Eight radiation oncologists at our center used CT and MRI to delineate five GTVs of liver tumors. In both CT and MRI, the GTV volumes were compared. Results: The median GTV volume on MRI was 2.4 cm3 (range=0.59-15.6 cm3) compared to 3.5 cm3 (range=0.52-24.9 cm3) on CT (p=0.36). The GTV volume as defined on MRI was larger or at least as large as the GTV volume on CT in two cases. Variance and standard deviation between observers in CT and MRI were minor (6 vs. 7.87 cm3, and 2.5 vs. 2.8 cm3 respectively). Conclusion: In cases with well-defined tumors, CT is easier and reproducible. In cases with no defined tumor in CT, other tools are needed and MRI can be complementary. The interobserver variability in target delineation of hepatocellular carcinoma in this study is noteworthy.
Feasibility and Safety of Super Energy-dense Oral Nutritional Supplementation in Postoperative Gastric Cancer Patients
Authors: FURUTA RYUICHIRO , HATAO FUMIHIKO , ITOKAWA MASANARI , YAMAZAKI RYOTO , MORIKAWA YOSHIHIKO , HONDA MASATAKA , IMAMURA KAZUHIRO , ISHIBASHI YUJI , MORITA YASUHIRO
Published: July 2023

Background/Aim: Ensuring that postoperative gastric cancer patients receive sufficient oral nutritional supplementation (ONS) to prevent body weight loss (BWL) is a serious challenge. The present pilot study evaluated the feasibility and safety of small, frequent sip feeds (SIP) with super energy-dense ONS (SED ONS; 4 kcal/ml) in postoperative gastric cancer patients. Patients and Methods: Patients received 400 kcal/day of SED ONS in four, daily, 25 ml SIP for 12 weeks after gastrectomy. The primary outcome was the percentage of postoperative weight change. The expected mean weight change was 90% (10% standard deviation). A sample population of 14 patients, sufficient for a 95% confidence interval with a 10% margin of error, was enrolled. Results: The mean weight change for patients receiving SIP with SED ONS was 93.8%. The mean SED ONS intake was 348 kcal/day. Thirteen patients consumed more than 200 kcal/day of SED ONS. One patient with a mean intake of 114 kcal/day had undergone total gastrectomy followed by adjuvant chemotherapy. Conclusion: Small, frequent SIP with SED ONS was found to be feasible and safe in postoperative gastric cancer patients. A multicenter randomized controlled trial is warranted to determine whether SIP with SED ONS is effective in preventing BWL.
A Case Report of Aggressive Fumarate Hydrase-deficient Renal Cell Carcinoma With Loss of HLA Antigens
Authors: MIURA YUJI , MOTOSHIMA TAKANOBU , ANAMI TOSHIKI , TAKEMURA KOHJI , KINOWAKI KEIICHI , OKA SUGURU , URAKAMI SHINJI , KAMBA TOMOMI , KOMOHARA YOSHIHIRO
Published: July 2023

Background: Fumarate hydratase (FH)-deficient renal cell carcinoma (RCC) is a rare RCC subtype, and FH-deficient RCC may be misdiagnosed as another type of RCC, such as type 2 papillary RCC or collecting duct carcinoma. FH and 2-succinocysteine (2SC) are useful diagnostic markers for FH-deficient RCC and can be measured using immunohistochemistry (IHC). Case Report: A 30-year-old female with 3-month history of fatigue and left-flank mass was diagnosed with a 20×13×10 cm left-side renal mass with massive inferior vena cava (IVC) tumor thrombus that extended into the right atrium. She underwent nephrectomy and IVC thrombectomy, and a pathological diagnosis of type 2 papillary RCC was made. Four months after the surgery, computed tomography scan showed multiple liver metastases not observed immediately after surgery. Systemic treatment with sorafenib was initiated; however, she did not respond and died 3 months after treatment. Subsequent re-review of hematoxylin and eosin–stained sections indicated morphologic characteristics consistent with FH-deficient RCC, and IHC staining was negative for FH but positive for 2SC, indicating a diagnosis of FH-deficient RCC. Further immunological analyses revealed the loss of HLA-class I, b2 microglobulin, and HLA-DR antigens in cancer cells. In addition, a few CD8-positive cytotoxic T cells and CD163-positive tumor-associated macrophages were noted. Conclusion: An immunosuppressive tumor microenvironment that facilitates cancer immune evasion might be associated with the rapid progression and poor prognosis in our patient. Further investigation of the tumor immune microenvironment in patients with FH-deficient RCC is warranted.
Análisis de las diferencias entre las medias de los indicadores financieros de empresas pesqueras en el periodo 2018-2021
Authors: Rossi Valverde Ricardo Manuel , Rossi Ortiz Ricardo Gabriel
Published: July 2023

El objetivo de este estudio fue analizar las diferencias entre las medias de los indicadores financieros de empresas pesqueras peruanas y chilenas en el periodo 2018-2021. Esta investigación de enfoque mixto y diseño DEXPLOS, utilizó ANOVA de un factor para comprobar la hipótesis. La muestra estuvo conformada por cinco empresas. Se halló que sí existen diferencias significativas entre las medias de los indicadores analizados en el periodo de estudio, destacando en el análisis Austral Group de Perú y Camanchaca de Chile. Una limitación correspondió a la escasa disponibilidad de estudios previos similares, lo que implica que este trabajo de investigación es inédito. En este trabajo no se incluyó un análisis de la gestión de las operaciones y no se consideraron otras variables inherentes al sector pesquero, sin embargo, la gestión empresarial finalmente termina reflejándose en los Estados Financieros y en consecuencia en los indicadores financieros. Se recomienda realizar estudios similares para comparar los resultados hallados con empresas del sector pesquero de otros países, de tal forma que se valide el modelo o mejorar el mismo con otras propuestas.
Predicting Suicide Risk among South African University Students: Optimal Cutoff Score for the Center for Epidemiological Studies Depression Scale
Authors: Pretorius Tyrone , Padmanabhanunni Anita
Published: July 2023

University students have been identified as a particularly vulnerable group for adverse mental health outcomes owing to the distinctive implications of the COVID-19 prevention measures on the educational sector. Even prior to the pandemic, university students were identified as being at increased risk for adverse mental health outcomes and suicidality. Although various factors can enhance the risk of suicide, one of the strongest predictors of suicidality is the presence of depressive symptomology. The current study used receiver operating characteristic (ROC) analysis to determine the optimal cutoff score on the CES-D when screening for suicide risk in university students during COVID-19 in South Africa. Participants (n = 337) were students at a historically disadvantaged university in South Africa. The ROC analysis showed no statistically significant difference between men’s and women's area under the curve (AUC); thus, a single AUC can be used for the whole sample. The study found that a cutoff score of 30 with a sensitivity of 89.30 and a specificity of 62.60 represented an acceptable cutoff point. It is recommended that when the instrument is used among student populations, those with scores of 30 and above need to be followed up with a clinician-administered interview to confirm suicide risk and facilitate timely intervention.
Molecular identification of a Pseudomonas putida strain isolated from Machángara river (Quito-Ecuador) tolerant to carbamazepine
Authors: Méndez Gabriela , Morales Leslie , Coyago Elena , Garzón Valeria
Published: July 2023

Carbamazepine is a molecule used to treat specific pathologies; however, it has become an emerging contaminant that is dangerous to the environment. In marine species and humans, it causes cytotoxicity, genotoxicity, reproductive disorders, and infertility. Thus, this pollutant has been subjected to conventional wastewater treatment, achieving low purification. In Ecuador, only some studies are related to emerging contaminants, and these show quantification but not treatment. Therefore, the implementation of biological techniques is necessary. In this sense, the research aimed to identify a bacteria in water samples from the Machangara River with carbamazepine tolerance. Morphological, biochemical, and molecular characteristics identified bacteria. The results indicated the presence of several microorganisms, including molecularly identified Pseudomonas putida. This was tolerant to carbamazepine concentrations of 15, 50, and 100 mg/L, with higher growth at the first concentration. This information can be valuable in wastewater treatment investigations.

Keywords: carbamazepine, degradation, Machangara river, Pseudomonas putida.
The Impact of Social Media Use Interventions on Mental Well-Being: Systematic Review
Authors: Plackett Ruth , Blyth Alexandra , Schartau Patricia
Published: July 2023

Background

There is some evidence that more social media use is related to poorer mental well-being and that social media use can become problematic when it starts to interfere with a person’s daily life and mental well-being. To address this issue and improve users’ mental well-being, social media use interventions (eg, abstinence from social media) have been developed and evaluated. However, there is limited understanding of the effectiveness of these interventions in improving mental well-being.

Objective

This systematic review aimed to synthesize the literature on the effectiveness of social media use interventions in improving mental well-being in adults.

Methods

A systematic search (January 1, 2004, to July 31, 2022) was completed across 3 databases in accordance with the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. Experimental studies evaluating the impact of social media use interventions on mental well-being in adults were included. Outcomes related to mental well-being, such as depression, anxiety, stress, and loneliness, were included. A narrative synthesis without meta-analysis was completed to summarize the study characteristics and effectiveness by outcome and intervention type. The Effective Public Health Practice Project Quality Assessment Tool was used to measure the quality of the studies.

Results

Of the 2785 studies identified through the systematic search, 23 (0.83%) were included in the analysis. Many of the included studies (9/23, 39%) found improvements in mental well-being, some (7/23, 30%) found mixed effects, and others (7/23, 30%) found no effect on mental well-being. Therapy-based interventions that used techniques such as cognitive behavioral therapy were more effective than limiting use of social media or full abstinence from social media, with 83% (5/6) of these studies showing improvements in mental well-being compared with 20% (1/5) and 25% (3/12), respectively. Depression was the most frequently investigated and improved outcome with 70% (7/10) of the studies showing a significant improvement in depression after the intervention, whereas other outcomes showed more varied results. Quality was poor, with 96% (22/23) of the studies receiving a weak global score, mostly for issues related to selection bias because most of the studies (16/23, 70%) used a convenience sampling of university students.

Conclusions

This review provides some evidence that social media use interventions are effective in improving mental well-being, especially for depression and when using therapy-based interventions. Further experimental and longitudinal research is needed with representative samples to investigate who may benefit most from social media use interventions. This will help to develop guidance and recommendations for policy makers and clinicians on how best to manage problematic social media use.
Null Hypothesis Proven in Sebum Infectant to Immune Reflex through Sebaceous Immunobiology by COVID-19 Vaccine (Preprint)
Authors: Pachankis Yang
Published: July 2023

BACKGROUND

The on-going interventional trial was conceived from the phenomena of COVID-19 post-vaccination adverse events. The accumulated evidence has proven the null hypothesis with significant results that falsify the predominant belief in the vaccination method. The alternative hypothesis is adjusted with proton equilibrium and sebaceous immunobiology’s correlations with immune reflex.

OBJECTIVE

The research purposes to locate the infection path.

METHODS

The sole-participant interventional trial compared the main medicines in myocarditis treatment from Nifedipine to angiotensin-converting enzyme inhibitor (ACEI) and angiotensin receptor-neprilysin inhibitor (ANRI) with increasing power level. T values and Z statistics are calculated for statistical analysis, and the introduction of proton-pump inhibitor is uncertain with the case’s neurodivergent conditions.

RESULTS

Inter-ACEI comparison suggests the introduction of beta blockers regulated the immune reflex through heart rate with the blood-borne pathogen. ANRI superiority suggests S2 pathogens can be more severe without S1 constraints, and raises alerts on SARS-CoV-2 mutational directions from Omicron. Historic data from the participant after the second COVID-19 vaccine shot recorded the viral entry through low-density lipoprotein cholesterol (LDL-C).

CONCLUSIONS

The study protocol with data refers to SARS-CoV-2’s S2 infection concentration and viral characteristics in LDL-C in human host. It is highly probable that S2 pathogen starts with LDL-C in vaccine poisoning. It is possible that HDL-C levels are responsible for the cytokine storms in neurologically infected cases. The placebo effect is maximized by the vaccine mandates, and the mass psychological biases need time to be narrowed down.

CLINICALTRIAL

The study protocol is retrospectively registered on ClinicalTrials.gov with the identifier number NCT05711810.
Exploration and Research on the Mixed Mode Curriculum of “Competition, Training and Teaching”
Authors: ZHANG C. N. , YU Y. , GUAN X. L. , LI Y. R.
Published: July 2023

In response to the many problems encountered in the teaching of the “SSM Framework” course, a project-driven hybrid teaching model is proposed. The reform integrates “Competition, Training and Teaching” into one, utilizes online teaching platforms to arrange pre-class activities, carry out interactive teaching in class, and improve post-class practice. In teaching, the roles of teachers and students should be exchanged to fully mobilize students’ learning initiative and cultivate their ability to solve and analyze problems. In the assessment, a process evaluation mechanism is introduced to incorporate project construction into the assessment scope and improve practical application capabilities. The practical results indicate that the application of the new model in curriculum significantly enhances students’ learning interest and practical abilities, which is feasible for promotion.
CAFFEINE INDUCED CERVICAL DYSTONIA-A CASE STUDY
Authors: CHAVAN ROHINI , KUMBHAR ANJALI , MANOCHA VINAY , RANE PRITISH
Published: July 2023

Dystonia is a movement disorder characterised by involuntary, extended, patterned, and often repetitive muscle contractions of skeletal muscles, frequently causing twisting movements or abnormal postures. Recent studies have shown that stress and coffee consumption can precipitate dystonic attacks. Many people, due to their diligent life schedules and increased physical inactivity due to less work-life balance, have been identified as the major cause of this neurological movement disorder. The action of caffeine and other CNS stimulants may be related to dystonic episodes in an individual. Cervical dystonia is specifically characterised by involuntary muscle contraction of the trapezius muscle, pain in the cervical region, numbness in one or both arms, and restricted movement. Proper understanding and management of spasmodic torticollis are necessary to avoid discomfort and progress towards a healthy life. The case study aims to highlight the role of physical activity along with proper work-life balance to live a healthy lifestyle and minimise the frequency of muscle spasm attacks caused by spasmodic torticollis. The role of clinicians such as physicians and clinical pharmacists in understanding and managing the disease is critical and crucial for a better quality of life and leading a stress-free life.
8th Graders’ Attitude Toward the Implementation of Project-Based Learning Method in Teaching English Reading Skills. A Case Study at Public Secondary School in Ho Chi Minh City, Vietnam
Authors: An Quach Hong
Published: July 2023

Teaching English reading skills in the Vietnamese educational context traditionally emphasizes direct-teaching methods, which often limit students' active involvement and real-world application of knowledge. This study aimed to explore a different pedagogical approach, Project-Based Learning (PBL), to teach English reading skills, with an objective to understand students' attitudes toward this innovative method. The research was conducted at a public secondary school in District 7, Ho Chi Minh City, Vietnam. The participants comprised of 50 eighth graders aged 14-15 years, offering a diverse group of English learners for the study. A mixed-methods research design was employed, using both a questionnaire and semi-structured interviews to collect data. The questionnaire, featuring 24 items across cognitive, behavioral, and affective domains, was designed to gauge students' perceptions and experiences with PBL in their English reading classes. Semi-structured interviews provided qualitative insights into these experiences, offering a richer understanding of student attitudes. The results revealed that implementing PBL in teaching English reading skills significantly improved students' engagement and learning outcomes. Cognitively, students reported enhanced understanding and retention of new English vocabulary, increased ability to infer meanings of unknown words, and better analytical skills. Behaviorally, PBL encouraged active participation, greater collaboration, and increased English reading beyond the classroom. Affectively, students felt more confident and accomplished, with reduced anxiety and a more positive attitude towards English reading. Nevertheless, certain challenges were reported, including initial project ambiguity and unequal group contribution. These findings suggest that PBL can be an effective strategy for teaching English reading skills, promoting active learning, and fostering positive learning experiences in the Vietnamese context. Future research could focus on optimizing PBL implementation, addressing reported challenges, and exploring its long-term impacts on English reading proficiency. This study hopefully contributes to the broader literature on PBL in English language learning and provides practical insights for educators aiming to enhance English reading skills among secondary school students.
Estudo funcional sobre a microconstrução [sabe (-se) lá que] como conector na língua portuguesa contemporânea
Authors: Ramos Nice Da Silva
Published: July 2023

Investigamos o estatuto da microconstrução [sabe (-se) lá que] utilizada com a função de conector textual na língua portuguesa atual, estabelecendo relações semânticas, além das discursivo-pragmáticas, entre as partes do texto, conforme Koch (2015, 2017). O escopo de atuação do objeto pesquisado não é limitado ao encadeamento de orações como estabelecido pela tradição no tocante à função dos elementos conectores. Conforme Rodríguez (2017), defendemos a existência da sintaxe de unidades superiores à sentença – a macrossintaxe. O aporte teórico utilizado é a Linguística Funcional Centrada no Uso, aliada aos pressupostos da Gramática de Construções. Justificamos essa escolha pelo relevo dado ao uso real da língua, aos aspectos linguísticos e extralinguísticos envolvidos nas análises, além da semântica e da pragmática, lócus do uso linguístico, que alimenta a mudança linguística. As instanciações de [sabe (-se) lá que] provêm do Corpus do Português NOW, com dados que figuram entre 2012 e 2019. Sobre a frequência token de [sabe (-se) lá que], encontramos 25 ocorrências assim distribuídas: [sabe-se lá que], com maior produtividade (24) e [sabe lá que], com menor produtividade (uma). Sintaticamente, verificamos seis posições em que a microconstrução é recrutada, bem como quatro valores semântico-pragmáticos a ela aferidos.
An Appraisal for the Working of Solar Water Heater System on Tribal of Himalayan Areas
Authors: Tamhid Ar. Varisha
Published: July 2023

Abstract: As the study proposed an appraisal for the working of Solar Water Heater System on tribal of Himalayan Areas is important to keen learn the power of nature. Our nature blessed us with so many blessings and one of them is sun. The continous change in climate that affects the ambient temperature and water in so many ways. So its our time to take an action to save our nature's earth by utilising different locally available materials, techniques to stop such activities that harm us and our surrounding. As water is one of the important and basic requirements for everyone. And in hilly areas where the temperature is low , the basic requirement is hot water. As the basic source of income for the local residents at these areas are mostly depend on tourist visits . So their restful environment and needs must be a provision. As the Solar water Heater system is costly way as one time investment but later it helps in several ways. Solar energy is one the best alternative way to replace the traditional requirement to heat the water like coal, gas, diesel etc. This system is designed to meet the energy demands. The size of the system depend upon the availability of the solar radiation, temperature and the orientation of the building. The given comprehension helps to understand the requirement and its working
Finite Element Analysis of Spur Gear
Authors: Sudarsanan Gowtham , R Ailan , Nair Anandhu. S. , R Palani
Published: July 2023

Abstract: Gear drive is crucial in control transmission businesses, as they are subjected to fluctuating loads, creating bowing and compressive stresses. Analyzing these stresses is crucial for safety operation and weight reduction. Gears are analyzed using AUTO CAD and ANSYS for inactive and modular examinations, considering materials like cast iron, carbon steel, brass, and copper
Experimental Study on Bacterial based Self-Healing Concrete
Authors: Sharma Vaidik , Singi Prof. Mayur
Published: July 2023

Abstract: The potential of concrete to self-heal has been studied in several works, hence in this study we are analyzing the strength properties of self-healing bacterial concrete by mixing bacteria (Bacillus Subtilis) with calcium source. In the study, bacteria (Bacillus Subtilis) were introduced at 3% and 5%, while calcium lactate was added at 5% and 10%, respectively. As a result, the study addresses economic issues not just for building but also for upkeep. The purpose of this experiment was to look into the strength qualities of bacterial self-healing concrete with varied ratios of Bacillus subtilis and calcium lactate. The researchers prepared concrete specimens with varied ratios of bacterial solution and calcium lactate and tested their compressive and flexural strength. The results revealed that adding Bacillus subtilis and calcium lactate to the concrete enhanced its compressive and flexural strength, with the maximum strength values recorded at a 3% bacterial solution and 5% calcium lactate combination. Furthermore, the concrete's self-healing potential was assessed by putting the samples to crack-healing experiments. The results demonstrated that the bacterial self-healing concrete containing Bacillus subtilis and calcium lactate performed better than the control samples without bacteria. The study reveals that using Bacillus subtilis and calcium lactate in concrete might increase the material's strength and self-healing capabilities, leading to enhanced durability and sustainability of concrete buildings.
Implementation halal product certification through self-declare program for MSEs products in Cirebon Regency
Authors: Umami Muhimatul , Nada Shofwatun , Anisa Nur Lulu
Published: July 2023

Cirebon is one of the regions of West Java which has around 54,306 MSMEs. However, currently, there are still many MSEs actors who don't understand the urgency of halal certification and incomprehensible how to apply for a halal certificate for their products. This community service activity aims to socialize and assist in applying for halal product certification for MSEs through the self-declaration program. The research method is Community Education through training and counselling conducted in the Pasaleman and Beber area with the category of food and beverage products. The data were used descriptive analysis. The results show that the mentoring participants gave a positive response to these activities, and MSEs received assistance in the practice of submitting halal products to the SIHALAL application. Some MSEs actors were able to apply for halal certification with the verification application status completed by National Fatwa Committee, LP3H, some were still in the draft submission and some had not yet submitted because business actors were more focused on product sales, so the time to complete the submission documents was limited. Furthermore, the community service team evaluates activities and monitors tracking periodically after submitting halal certification until release certificate halal product.
Improving knowledge and attitude to tackle covid-19 transmission in a health care facility of North Sumatra’s village
Authors: Mayasari Evita , Lubis Lokot D. , Meutia Nuraiza , Megawati Eka R.
Published: July 2023

COVID-19 hits Indonesia with massive social restrictions in many aspects of life. In some Indonesian rural areas, information related to the pandemic through online platforms and social media is accessible. However, most of the information is inaccurate. Improving individual knowledge is crucial to support the government’s campaign for COVID-19 prevention. This cross-sectional, pretest-posttest study aims to evaluate the knowledge and attitude of health personnel toward COVID-19 prevention in a primary healthcare facility in a rural area of North Sumatra. All twenty-two health personnel who worked in the hospital during the study were asked to fill in a two-sectioned questionnaire. The first section contained questions related to knowledge, and the second section was related to attitude toward COVID-19. Following the educational activity, each health personnel filled in the same questionnaire again. We analyzed the data statistically using two-way ANOVA (p<0.05, 95% CI). There were increases in knowledge (p < 0.001) and attitude (p = 0.0002) of the health personnel after the educational activity. Educational activity improves health personnel’s knowledge and attitude regarding COVID-19 prevention.
Health education on disaster triage as an effort to change the attitudes of people living in tsunami-prone areas
Authors: Islamy Aesthetica , Lasman L. , Yuliastuti Wiwid , Suharyoto S. , Anggraini Ria , Suciati S. , Nurhidayati N. , Audilla Amita , Masruroh Eny
Published: July 2023

Indonesia as an archipelagic country located on the equator, between the continents of Asia and Australia and between the Pacific and Indian Oceans. Indonesia's geographical location lies on an unstable earth plate. Indonesia is also one of the disaster-prone areas, so that people in coastal areas must know what disaster management is most important to provide. This encourages community knowledge to provide first aid in a disaster situation using the principle of triage. The purpose of this activity is for the community to know about disaster management, especially the triage system in disaster-prone areas. The target of this activity is the community in Kalibatur Village, RT 05 RW 02, Kalidawir District, Tulungagung Regency. The implementation of this activity was carried out by pre-test and post-test. Data analysis was performed using the Wilcoxon Signed Range test analysis. Statistical test results obtained p value = 0.001 < α = 0.05. After the implementation of health education and counseling, the community has a positive attitude and a change in attitude regarding disaster triage as an effort to deal with and control victims of preventive natural disasters.
Enhancing the productivity of farmer community in producing organic fertilizer and local plant-based pesticide
Authors: Widnyana I Ketut , Pandawani Ni Putu , Yastika Putu Edi , Partama I GD Yudha , Wijaya I Made Wahyu
Published: July 2023

These activities are expected to improve the agriculture community resilience in Batukaang Village to achieve a sustainable agriculture practice. Through a training and assisting program, the farmer community will get improved their skill to make their own fertilizer and pesticide by utilizing organic waste and local material. These activities contribute to the achievement of SDG 2: Zero hunger, since agriculture in Batukaang Village is the most sector that support the economics and food security. The activities resulted in increasing the knowledge and skill of farmer community in Batukaang Village. By enhancing the farmers with the knowledge, skills, and resources required to produce their own organic fertilizer and pesticide, they can promote soil health, reduce environmental pollution, and enhance the well-being of agricultural communities as a whole. It support resilient agricultural systems that promote sustainable practices, safeguard natural resources, and enhance farmers' livelihoods in Batukaang Village.
Optimalisasi Aplikasi SIDeKa-Pro Dalam Upaya Peningkatan Kedisiplinan Pengisian Data 10 Besar Penyakit Rawat Jalan Melalui Pembuatan Standar Operasional Prosedur (SOP)
Authors: Suryanto Hikmawan , Subekti Hakim
Published: July 2023

Pencatatan dan pelaporan kini telah mengalami proses evolusi dari kertas ke digital. Demikian pula pencatatan dan pelaporan pelayanan kesehatan di Kota Probolinggo menggunakan aplikasi SIDeKa-Pro. Pada prakteknya masih terdapat fasilitas pelayanan kesehatan yang terlambat dalam pengisian data di aplikasi SIDeKa-Pro. Sebanyak 56% fasilitas pelayanan kesehatan di Kota Probolinggo pada tahun 2020 terlambat mengisi 10 besar data penyakit rawat jalan di aplikasi SIDeKa-Pro. Kemudian, sebanyak 38% fasilitas pelayanan kesehatan di Kota Probolinggo pada Januari – Maret 2021 terlambat mengisi data 10 besar penyakit rawat jalan di aplikasi SIDeKa-Pro. Tujuan dari penelitian ini adalah untuk mengetahui tingkat keterisian data 10 besar penyakit rawat jalan sebelum dan sesudah standar operasional prosedur (SOP). Penelitian ini menggunakan studi kohort. Jenis penelitian ini adalah eksperimen, yaitu one shoot case study. Populasi dalam penelitian ini adalah seluruh pengelola data di fasilitas kesehatan yang telah terdaftar di aplikasi SIDeKa-Pro sebanyak 32 fasilitas pelayanan kesehatan. Teknik pengambilan sampel yang digunakan adalah total sampling. Hasil penelitian menunjukkan bahwasannya adanya SOP pengisian data di SIDeKa-Pro ternyata mampu meningkatkan kedisiplinan pengelola fasilitas pelayanan kesehatan dalam pengisian data 10 besar penyakit rawat jalan di aplikasi SIDeKa-Pro. Saran adalah semua semua organisasi yang memiliki aplikasi, hendaknya dibuatkan SOP.
E. JUNGER AND THE ASSERTION OF THE NAZI GOVERNMENT: AN INTELLECTUAL'S SURVIVAL STRATEGY DURING THE YEARS OF NAZI DOMINATION
Authors:   Academician I.G. Petrovskii Bryansk State University (Russia), Artamoshin S. V.
Published: July 2023

The article discusses the issues of developing a strategy of behavior and survival of an intellectual in the conditions of the Nazi dictatorship on the example of the German conservative thinker and writer Ernst Junger. The formation of the Nazi government in January 1933 marked the end of the deep crisis of the Weimar Republic in the early 1930s. As a result of the formation of Hitler's Nazi-conservative coalition cabinet in the German state, the process of structural transformation of the state towards the Fuhrer state, assuming total control and management of the entire life of society, began. Under these conditions, the existence of an intellectual required a choice between conformity and nonconformism. The example of Ernst Junger, a well-known nationalist publicist, shows how non-trivial the ways of existence of a thinker can be in the conditions of the beginning regulation of public life and repression against opposition forces and ideas.