bluuebunny/crossref_metadata_2025 huggingface dataset:
Il non-luogo della relazione tra famiglie e servizi per l’infanzia, nell’editoria accademica sull’educazione 0-6, in Brasile
Authors: Oliveira Canavieira Fabiana
Published: July 2024

The paper summarizes the results of a bibliographic investigation on how Brazilian academic production addresses the theme of the family (or, better, families), with particular attention to the education of children in the 0-6, and to ECEC services. The research, at the heart of which is the analysis of a selection of scientific papers published in the most qualified and representative Brazilian journals in the field of education – while not claiming to be exhaustive – was divided into three phases. 11 journals were taken into consideration, for a total of 95 issues/editions, published between 2020 and 2024, analyzing a total of 2.495 articles. Of the aforementioned contributions, only four fall within the delimited thematic scope, crossing the descriptors “Family” and “Families” and the boolean operator AND “Early Childhood Education”. After having noted the, therefore, limited national scientific production in this area and having analyzed the selected articles, we concluded that research involving the family(s) and education category does not yet have a relevant space in Brazilian academic production, which appears to be addressed this macro-topic in an overall superficial way, addressing such a complex topic in a generally banal and reductive way.
Educazione di genere e sostegno alla genitorialità. Una rete per le famiglie in tras-formazione
Authors: Forni Dalila , Dello Preite Francesca
Published: July 2024

The essay presents initial findings from an action-participatory research project that resulted from collaboration between the FORLILPSI Department of the University of Florence and the Early Childhood Education Services of the Municipality of Livorno. Starting with an analysis of the changes affecting contemporary society and families, this research aimed to identify the resources and actions that have been promoted in the Livorno area over the last five years for gender and parenting education. The ultimate goal is to design and build an inter-institutional and inter-professional network that supports intra- and inter-family relations through an inclusive and transformative approach. The paper presents the theoretical foundations, objectives, methodology, and initial results of the project. It also presents the hypothesis of the steps to be taken to establish and operationalize the network.
The Future Classroom: Analyzing the Integration and Impact of Digital Technologies in Science Education
Authors: Farooq Erum , Zaidi Erum , Shah Muhammad Meeran Ali
Published: July 2024

The present study is a systematic and bibliometric literature review aimed at evaluating the incorporation of digital technologies in science education and their subsequent impacts. The review exclusively utilizes the Scopus database and covers literature from January 2019 to December 2023. The primary focus is on empirical studies that investigate the use of digital technologies in science education and their effects on educational outcomes such as student engagement, motivation, and academic performance. Notably, the key findings reveal a significant increase in the number of publications during this period, indicating a growing interest in the role of digital technologies in enhancing science education. The review corroborates the transformation of science education through digital technologies such as augmented reality (AR), virtual reality (VR), and blended learning environments, which have made learning more interactive, personalized, and accessible. However, challenges such as the digital divide, resistance from educators, and the need for continuous professional development persist. These challenges emphasize the importance of strategies to enhance digital literacy among educators and promote equitable access to technology. The review recommends the development of comprehensive training programs for educators, ensuring that all students have access to the necessary digital tools, and maintaining robust data protection measures. By addressing these issues, the integration of digital technologies in science education can be optimized, resulting in enhanced educational outcomes and better preparation of students for a technology-driven world.
PERANCANGAN E-LEARNING BERBASIS WEB DI SMK SIDRATUL MUNTHAHA YAPIS WAMENA PAPUA DENGAN METODE BLACKBOX
Authors: Syarifah Syarifah , Abd Latif Kurniadin
Published: July 2024

Di era teknologi yang semakin berkembang pesat di segala bidang, proses pembelajaran di Daerah 3T khususnya SMK Sidratul Munthaha Yapis Wamena Papua masih melakukan proses pembelajaran secara konvensional. Hal tersebut membuat beberapa siswa dan guru belum maksimal dalam mengenal dan mengimplementasikan teknologi di bidang pendidikan. E-learning telah berkembang dan diaplikasikan di berbagai sekolah. Namun, belum sepenuhnya kemudahan tersebut dirasakan oleh siswa dan guru di Wamena Papua. Tujuan penelitian ini adalah merancang e-learninng berbasis web serta menguji tingkat kelayanan sistem e-learning dengan metode blackbox. Metode perancangann yang digunakan yaitu menggunakan metode waterfall dengan tahapan analisis, desain, pengkodean, dan pengujian. Pengujian dilakukan menggunakan metode black box. Hasil penelitian menunjukkan bahwa bahwa ada lima tampilan interface pada e-learing yang telah dirancang yang terdiri dari tampilan beranda, halaman login, form buat classroom, form posting materi, dan tampilan presensi. Berdasarkan hasil pengujian blackbox, membuktikan bahwa sistem e-learning dapat digunakan sesuai dengan fungsi yang diharapkan. Namun, ada beberapa catatan pada perancangan e-learning ini dari ahli media, diantaranya: perlu memberikan validasi pada deskripsi tugas, mengotomatisasi waktu terbit tugas, memberikan informasi halaman pengumpulan tugas, dan mengotomatisasi waktu upload tugas.
Knowledge, Attitude and Practices- A Concept
Authors: Tripathy Dr. Tridibesh , Das Shankar , Singh D. P. , Tripathy Byomakesh , Tripathy Anjali , Sahu D. R. , Dwivedi Rakesh , Gautam Dr. Mohini , Tripathy Ms. Sanskriti
Published: July 2024

The current article deals with the concept of Knowledge, Attitude& Practices (KAP) that emerged from the family planning programs after independence of the nation. Further, the concept of KAPGap emerged regarding the improvement of quality of the family planning programs. Development of the concept of KAP gap helped improved the quality of the family planning program & the program name changed to Family Welfare program. Further, it also provided a cafetoria approach of family planning methods where the people had to choice to chose from the available basket of methods of family planning/welfare. The current article traverses the history of the KAP approach, thereafter it sees how it sailed through finally reaching the current status of the KAP approach through the indicator of unmet need of family planning through the National Family Health Surveys of 4th& 5th rounds.
Evaluation of the Effectiveness of Streptomyces sp. Against Biofilm-Forming Bacteria and Starch-Protein degradation
Authors: Abdzaid Ahmed Majeed , Alkhuzaie Mohammed Mudhafar , Hezam Abbas Mayar
Published: July 2024

Streptomyces sp. play important role in controlling pathogenic bacteria by using different mechanisms so this study aims to diagnose the Streptomyces sp. and select strains having the ability to inhibit biofilm-forming bacteria and degradation proteins and starch. The capacity of bacteria to produce biofilms was examined by staining with 1% crystal violet. The ability to inhibit biofilm-forming bacteria, proteolytic and amylolytic, were determined by bacterial drop and well diffusion methods. The bacteria capable of creating biofilms were isolated from urinary tract infection and identified by biochemical reactions and sequencing the 16S rRNA gene. The Selected 6 Streptomyces strains which were isolated from soil are capable of inhibiting the growth of Escherichia coli and capable of degrading protein and starch. The strain STV1 was selected for 16S rRNA gene sequencing with standard isolates. Isolation of Escherichia coli capable of forming biofilm from urinary tract infection. Selection of Streptomyces sp strains capable of inhibiting biofilm-forming bacteria. The research is the first step to studying the application of Streptomyces sp in inhibiting biofilm-forming bacteria and in treating organic matter.
Prevalence of Helicobacter pylori Infection in Diabetics Type 2 and Non-Diabetics Subjects in Brazzaville CHU
Authors: Boyina Gainze , Mikolélé Apendi Ahoui , Pouki Freddy Saturnin , Landry Miguel , Mbamognoua Nestor Ghislain Andzouana , Takale Ragive , Batchy Aladin Atandi- , Dobhat Choupette Ravelle , Ngouma Ange Malonga , Boumba Magloire Anicet , Mokondjimobe Etienne
Published: July 2024

H. pylori is a micro-aerophilic, gram-negative, S-curved, polar motility, spiral bacillus measuring 2.5 µm to 5 µm long and 0.3 µm wide. Type two diabetes of mellitus is a metabolic disorder characterized by chronic hyperglycemia associated with disturbances of the various metabolisms, in particular lipid, carbohydrate and protein. In this study, we aimed to determine the prevalence of H. pylori infection in the diabetic and non-diabetic population consulting in the gastroenterology and external medicine department of CHU-Brazzaville. We carried out a descriptive cross-sectional study over a period from June 20 to November 02, 2021, like a period of six months. Ninety patients were selected divided into two groups, each subdivided into two subgroups. 44 type two diabetes of mellitus patients and 46 non-diabetic patients were included. The average age of diabetic patients was 51 ± 11 years old with an average duration of diabetes evolution of 5.54 ± 4.58 years old. The average age of non-diabetic patients was 40±15 years old. Out of 90 patients in our study population, we had a predominance of women (68) compared to men (22). The overall frequency of H. pylori infection of the study population was 57%. It was 66% in diabetic patients and 48% in non-diabetics. The results of our study showed that H. pylori infection was more common in diabetics compared to non-diabetics.
Hypolipidemic And Testicular Cytoarchitecture Protective Effects of the Hydromethanol Leaf Extract of Craterispermum schweinfurthi in Male Wistar Rats
Authors: F Saronee,
Published: July 2024

Hyperlipidemia is implicated in many disease states, including arteriosclerosis, diabetes mellitus, hypertension, obesity and stroke amongst other illnesses. The present study describes the hypolipidemic and testicular cytoarchitecture protective effects of hydromethanol leaf extract of Craterispermum schweinfurthi using male Wistar rats as models. 64 male Wistar rats were acclimatized and subsequently randomly divided into 8 groups of 8 rats each. Diabetes was induced in all rat groups except Groups 1 and 8 using alloxan at a dose of 200mg/kg bw administered intraperitonially. Diabetes was confirmed after 72 hours of alloxan administration if the blood glucose level is ≥ 11.1 mmol/L (200mg/dl) and were daily treated with different concentrations of extract and phytosterol only for 28 days. Expectedly, significantly higher values of total cholesterol, triglyceride, low density lipoprotein, low values of high-density lipoprotein and significant reduction in the population of epithelial germ cells and normal matured spermatozoa in the testes were observed amongst group 2 (Untreated Diabetes) rats administered 200mg/kg bw of alloxan, compared to group 1 (Control) rats (p<0.05). Suggesting a possible hyperlipidemic and harmful testicular effects of alloxan in male Wistar rats. By corollary, extract administration significantly lowered values of total cholesterol, triglyceride, low density lipoprotein, increased values of high-density lipoproteins and reversed the reduction in germ cells and matured spermatozoa population amongst Groups 4 and 5 rats administered 500mg/kg bw and 750mg/kg bw of the extract of Craterispermum schweinfurthi compared to Group 2 (Untreated Diabetes) rats (p<0.05). Suggesting a possible reversal and protective effects of the extract. Craterispermum schweinfurthi extract administration lowered total cholesterol, triglyceride, low density lipoprotein, increased serum high density lipoprotein concentration and promoted germinal epithelial cells ...
Diverticulitis Surgery Outcomes: Insights from Our Clinical Practice
Authors: Topal Uğur , Kaycı Yunus , Yavuz Burak , Aydın İshak , Dalcı Kubilay , Yalav Orçun , Eray İsmail Cem
Published: July 2024

Aim: To assess outcomes of diverticulitis surgery, focusing on various patient phases at a tertiary center and incorporating literature insights.

Materials and Method: Analysis included diverticular disease surgeries at *** University's General Surgery Clinic over five years, examining demographics, disease specifics, surgical details, stoma aspects, and complications. Patients were categorized into emergency and elective groups for comparison based on Hinchey scores and stoma status.

Results: Of the patients, 72% were male, with an average age of 58.46. The sigmoid colon was predominantly affected (84%). Percutaneous drainage was used preoperatively in 44%, and 56% required a stoma, primarily Hartmann colostomies (36%). The median stoma closure time was 5 months, with 10 patients unable to have their stoma closed. Emergency surgeries were associated with higher Hinchey stages (III-IV) and an increased need for stoma creation (81% vs. 16% in elective surgeries).

Conclusion: The study indicates a median 5-month duration for stoma reversal, with sigmoid colon being the common site regardless of gender. Emergency surgeries showed a higher rate of stoma creation, suggesting elective surgeries could reduce stoma necessity. Further investigation is needed for broader applicability.
Impactos da cirurgia robótica no tratamento da miomatose uterina: Desfechos e complicações
Authors: Dos Santos Medeiros Myckanne Mirelle , Barbalho Filho Eli Pinto , Cordeiro de Almeida Guilherme Vitor , Augusta de Melo Katiane Fernanda , Nunes Isaac de Santana , Menezes Heitor Keila Cristina , Rosa de Albuquerque Mayara Cavalcanti , Souza Laura Stankowich , Cordeiro de Almeida Caroline , Damaso Lisboa Costa Marcelo Danilo , Torres Magalhães Alexandre , Araújo de Lira Rayra Luiza
Published: July 2024

Introdução: Os leiomiomas são os tumores mais comuns de útero e pelve. Possuem alta morbidade e constituem a maioria das indicações cirúrgicas em ginecologia. Com a finalidade de preservar a fertilidade das mulheres jovens e garantir um procedimento menos traumático, a cirurgia robótica emergiu como uma técnica eficaz no tratamento dessa patologia. Metodologia: Realizou-se uma revisão ingrativa nas bases de dados PubMed e Biblioteca Virtual em Saúde, com a pergunta norteadora de pesquisa: Quais os impactos da cirurgia robótica no tratamento da miomatose uterina? Foram utilizados os descritores “cirurgia robótica” e “miomectmia”. Foram utilizadas 16 publicações entre 2014 e 2014, sem qualquer restrição de idioma.  Resultados e Discussão: A cirurgia robótica apresenta melhores resultados em relação à cirurgia aberta.  Consiste na menor formação de bridas, menor perda sanguinea, menos tempo de internamento hospitalar e complicações. É capaz de retirar um número maior de tumores e progredir em localizações desfavoráveis. Em comparação com a cirurgia laparoscópica, a modalidade robótica não demonstrou diferenças significativas quando realizada por um cirurgião ginecológico habilitado e com grande fluxo de pacientes. Não houve resultados distintos, embora a cirurgia robótica tenha apresentado tempo e custos maiores. Conclusão: Mesmo com uso crescente, a aplicação da cirurgia robótica enfreta desafios. As vantagens dessa modalidade cirúrgica não se mostraram suficientes para torná-la padrão-ouro no tratamento da miomatose uterina quando comparada à laparoscopia.
LEVANTAMENTO DE SEIO MAXILAR VIA CRISTA: PROPOSTA DE TÉCNICA HÍBRIDA
Authors: Alves Gusmão Nathalia , Dornelas Prates Freitas Iuri
Published: July 2024

A perda de dentes na região posterior superior resulta em remodelação óssea e pneumatização do seio maxilar, o que complica a reabilitação com implantes dentários devido à insuficiência de altura óssea. Este relato objetiva demonstrar uma técnica híbrida para levantamento do seio maxilar via crista, utilizando expansores e compactadores ósseos (Bone Expander). Uma paciente de 49 anos buscou atendimento para a instalação de um implante na região do dente 27. Foi proposto um implante unitário com levantamento do seio maxilar via crista, para a inserção de um implante Cone Morse (CM) 4.5 x 10 mm. A preparação do alvéolo do implante seguiu os princípios de Summers, utilizando alargadores ósseos do Kit Bone Expander® para compactação do alvéolo e garantir a estabilidade do implante. O soalho do seio maxilar foi rompido com a Trefina LSM® (Maximus) e o levantamento realizado com o Compactador de Summers com stop® (Maximus). Por fim, o último alargador foi usado para inserção do biomaterial no alvéolo conformado. O implante foi inserido com um travamento de 35 N/cm². A técnica híbrida apresentada é uma modificação da técnica de Summers, substituindo os osteotomos de Summers pelo Bone Expander. Além disso, obteve-se compactação da parede alveolar, melhorando o travamento primário e proporcionando maior conforto ao paciente.
Abordagens inovadoras no tratamento da mielomeningocele: uma revisão da literatura atual
Authors: Pereira Levada Leonardo , Lobo Ferreira Ingrid , Faria Mendes Mariana , Henrique Chies Filho Alexandre , Matheus Pongitory Cavalcante William , De Oliveira Castelo Lucas , Vitória Costa Bentes Rodrigues Emily , Da Silva Rampasio Enrico , Gabriel Olivoto Salgueiro João , Gomes de Oliveira Júlia , Flávia Duque Nunes Ana , Bruna Real Antonio Giovanna , Manuela Cecchini Souza Damasceno Nogueira Maria , Pinto Martins de Oliveira Rafael , De Freitas Jardim Juliano , Trindade de Abreu Camila , Cardoso Marco Tulio
Published: July 2024

A mielomeningocele, uma forma grave de espinha bífida aberta, é uma malformação congênita do sistema nervoso central. Caracterizada pela exposição da medula espinhal e meninges devido a um defeito no fechamento do tubo neural durante o desenvolvimento fetal, a condição apresenta diversas complicações neurológicas e médicas ao longo da vida. O tratamento inclui o fechamento precoce do defeito para prevenir infecções e danos adicionais à medula, além de uma abordagem multidisciplinar para gerenciar complicações como hidrocefalia, disfunção urológica e problemas musculoesqueléticos. Avanços como a cirurgia fetal oferecem novas perspectivas, embora exijam mais estudos para validar sua eficácia ampla. A suplementação com ácido fólico é crucial na prevenção da espinha bífida, destacando a importância da saúde materna. Considerações econômicas e éticas ressaltam a necessidade de políticas de saúde robustas para apoiar essas intervenções complexas.
FATORES DE NÃO ADESÃO DE MÃES DE CRIANÇAS ENTRE 05 A 11 ANOS AS VACINAS CONTRA COVID-19
Authors: Ellen Patricia Fonseca Alves  , Bruno Souza Miranda  , Emmilly Lucciane Alves Maria  , Eduardo Ferreira Moura Ribeiro  , Mariana Stefany Cardoso Nascimento  , Joice Fernanda Costa Quadros Pimenta  , Ana Carolina Costa Maia Pinheiro  , Marcell Gonçalves Grillo  , Fernandez Fonseca Almeida  , Marlete Scremin  , Lázaro Breno Antunes  , Maria Rafaela Alves Nascimento  , Brenda Letícia Moura Cruz  , Agna Soares da Silva Menezes  , Michelle Meira Vieira  , Amanda Caroline Rodrigues de Oliveira
Published: July 2024

Objetivo: compreender os fatores de não adesão de mães de crianças aos imunobiológicos contra covid-19 na faixa etária de 05 a 11 anos. Materiais e métodos: trata-se de um estudo qualitativo, descritivo e transversal realizado com participação de 14 mães que responderam a um questionário aberto composto por seis perguntas, elaborado pelas próprias autoras. Após a transcrição das respostas, realizou-se a categorização das falas das participantes como proposto pela metodologia de Bardin. Resultados: observou-se três categorias após a leitura minuciosa das respostas das mães: tempo de pesquisa curto das vacinas de Covid-19, medo em relação aos efeitos adversos nas crianças e influência de notícias sobre eventos adversos da vacina. Discussão: tem-se um cenário permeado por Fakes News, desarticulação na política e a pouca visibilidade de estudos científicos por parte da população como fatores contribuintes para não adesão por parte das mães as vacinas contra Covid-19. Considerações finais: é possível perceber que desde o início da vacinação nas outras faixas etárias houve um crescente declínio do número de casos da doença no país, assim a vacinação das crianças contribui para a menor transmissibilidade do vírus e no controle epidemiológico da doença.
AVANÇOS NO TRATAMENTO BIOLÓGICO DA PSORÍASE: EFICÁCIA E SEGURANÇA A LONGO PRAZO
Authors: Denise Krishna Holanda Guerra  , Beatriz de Melo Acioli  , Chung Won Chon  , Bene Rafael Jambo  , Luiz Henrique Caldas Lins  , Sheyla Milena Costa de Souza  , Italo Fernando Morais de Castro  , Juliana Ribas Souza  , Maria Ribeiro Gonçalves  , Mariana Alves da Costa  , Martina Albuquerque Santin
Published: July 2024

Os avanços nos tratamentos biológicos para a psoríase têm transformado significativamente o manejo desta doença crônica, proporcionando opções terapêuticas altamente eficazes e seguras a longo prazo. Este artigo de revisão aborda a evolução dos tratamentos biológicos, destacando os principais tipos, como inibidores de TNF, IL-12/23, IL-17 e IL-23. Estudos clínicos mostram que esses medicamentos oferecem alta eficácia, com muitos pacientes alcançando remissão duradoura e melhora significativa na qualidade de vida. No entanto, a segurança a longo prazo é uma preocupação importante, com riscos associados a infecções e, em alguns casos, malignidades. A monitorização rigorosa e a educação do paciente são essenciais para garantir a segurança e a adesão ao tratamento. Além disso, as análises de custo-efetividade indicam que, apesar do custo inicial elevado, os tratamentos biológicos são economicamente viáveis devido à redução da carga da doença e melhoria da produtividade. A pesquisa contínua e o desenvolvimento de novas terapias, bem como a personalização do tratamento, são fundamentais para otimizar os resultados terapêuticos. Este artigo conclui que os tratamentos biológicos representam uma opção poderosa no manejo da psoríase, com a necessidade de contínua avaliação de eficácia e segurança, e esforços para tornar esses tratamentos acessíveis a todos os pacientes.
WIKANG BAHAGHARI: ANALYSIS OF THE CONTEMPORARY VISAYAN GAY LINGO
Authors: Niño Paul T. Aguilar  , Cristine Joy S. Bughao  , Rhea L. Cingculan  , Kristel G. Entrada  , Shiello P. Juanico  , Jesha D. Pusa  , Mark B. Galdo
Published: July 2024

This research aims to identify Visayan gay-lingo's contemporary-Bekimong Bisaya. This study examines the unique gay language used in Southern Leyte, which includes the analysis of its meaning, importance, etymology, and usage in daily conversations. According to this study, the Visayan gay-lingo or bekimong Bisaya is a sociolinguistic, gender-based language medium that is been utilized by gay men in their interaction with other people. There are words spoken backward, words with added sounds, added letters, and words with different spellings. Some words originated from different celebrities and personalities with different, fresh meanings. The Visayan gay lingo (bekimong Bisaya), similar to the gay lingos spoken in the different regions of the Philippines, has no formal structure, specification, conventions, or subscriptions to grammatical rules. It is a dynamic, creative, and free-flowing language that shaped the gay perspective.
KEYWORDS – bekimon, Bisaya, Gay Lingo, gender-based language medium, sosyolek, Visayan
Factors Influencing Public University’s Role in Community Transformation
Authors: Asaf Adebua , George Oriangi , Elaijah Edekebon , Betty Ezati Akullu , Charles Amone
Published: July 2024

Paucity of knowledge exists on the factors that influence the capacity of universities to transform communities, particularly in the Ugandan context. This study examined the internal factors that influence the capacity of Gulu University to contribute to community transformation in Gulu City in Northern Uganda. A cross-sectional study design was used while employing self-administered questionnaire to sample 390 households. Logistic regression model was used to evaluate the influence of internal factors on Gulu University’s role in transforming the surrounding communities. Findings revealed that scholarships by the university (p=.000), enterprises developed within the community through Gulu University’s engagement (p=.007), religious meetings for spiritual transformation (p=.036), and the teaching done at the university (p=.045) had a statistically significant influence on the university’s role in transforming the surrounding community in Gulu city. The study concludes that universities, the central government, and other stakeholders need to focus more on scholarships for further education, enterprise development, supporting the church, and teaching in the university to realise multiplied transformation of the surrounding communities
Structural biology of HER2/ERBB2 dimerization: mechanistic insights and differential roles in healthy versus cancerous cells
Authors: Santhanakrishnan Jayasree , Meganathan Prabhu , Vedagiri Hemamalini
Published: July 2024

Aim: Present study was done to understand the dimerization of HER2/ERBB2 in normal and cancer cells using in-silico study. Methods: Pathway analysis was done using Reactome. Structure of HER2/ERBB2 protein was obtained from PDB database, and using Schrödinger software protein structure was analysed and dimerization was done. Results: In normal cells, HER2/ERBB2 is present at low levels and forms a stable complex with HSP90 (heat shock protein 90), CDC37 (cell division cycle 37), and ERBIN (an adaptor protein of the HER2/ERBB2 receptor). HER2/ERBB2 lacks a ligand-binding site, so it cannot bind ligands to activate HER2/ERBB2 signaling directly. Instead, it heterodimerizes with other EGFR family members, using their ligand-binding sites to activate cell proliferation signaling cascades. In cancer, overexpression of HER2/ERBB2 leads to ligand-independent activation of signaling through dimerization. During this process, HER2/ERBB2 dissociates from the HSP90 complex. Normally, HSP90 helps to correct misfolded and aggregated proteins, but it fails to correct mutated HER2/ERBB2 in cancer cells. Conclusions: This discussion focuses on the structural changes that HER2/ERBB2 undergoes, particularly in the form of homodimers, under normal and cancerous conditions. This analysis highlights the mutated state of HER2/ERBB2 and the role of HSP90 in this context. Notably, a single-point mutation outside a protein’s active site can significantly alter its structure. This is a critical consideration in drug discovery, underscoring the need to evaluate the entire protein conformation during simulations.
المرأة الأغريقية في الالياذة والاوديسة
Authors: سالم رزيق كمال
Published: July 2024

In the Iliad and the Odyssey, Greek women are portrayed differently according to the role they play in the story. In the Iliad, there are several influential women in the novel. Women in this work are usually depicted as wives, mothers or sisters, who are supporters of heroic men and a source of inspiration for them. They are portrayed as strong and wise characters who use their wisdom and cooperation to preserve the family and society. As for the Odyssey, a variety of female characters are presented. Women in this work are sometimes depicted as attractive and exotic beings, like the breathtaking nympho Kirke. Some of them possess divine qualities and supernatural power, such as the witch Helena and the virgin princess nausica. However, many of the women in the two novels appear weakly and impressively, portrayed exceptionally for male narrators. They are often considered royalty, be it the wives of Odysseus, victims of wars or sculptures representing the sexual passions of the hero. In general, the role of Greek women in the Iliad and the Odyssey is described in a diverse and complex way, reflecting the traditional image of women in ancient Greek society. Women may be influential and inspiring forces, but they also suffer from cultural and social limitations and challenges.
مقومات زراعة الخضر بمنطقة المرج ومعوقاتها "دراسة في الجغرافية الزراعية"
Authors: محمود المهدي د. فضل الله
Published: July 2024

تناولت هذه الدراسة جانب مهم من النشاط الزراعي ممثلا في زراعة محاصيل الخضر بمنطقة المرج في محاولة لتحديد العوامل الجغرافية المؤثرة في محاصيل الخضر ونوع وتوزيع مساحات الخضر والتركيب المحصولي، وإبراز معوقات زراعة محاصيل الخضر بالمنطقة، ضمن ثلاثة محاور رئيسية هي مقومات الاقليم الطبيعية والبشرية، وتوزيع محاصيل الخضر وتركيبها المحصولي، والعقبات المؤثرة في مساحتها وكمية انتاجها، وقد استخدمت هذه الدراسة عدة مناهج أهمها المنهج الاقليمي لتحديد منطقة الدراسة والمنهج الاصولي لتتبع أثر المقومات الجغرافية بالنشاط الزراعي. وانتهت هذه الدراسة بجملة من النتائج والتوصيات المرتبطة بتنمية النشاط الزراعي بشكل عام وزراعة محاصيل الخضر بشكل خاص.
دراسة أثر جودة الحياة الوظيفية على فاعلية اتخاذ القرارات الإدارية - دراسة تطبيقية على جامعة اجدابيا
Authors: الـــزوي أ. الأمين
Published: July 2024

هدفت هذه الدراسة الى التعرف على اثر جودة الحياة الوظيفية على فاعلية اتخاذ القرارات الادارية في جامعة اجدابيا، وقد اعتمد فيها على المنهج الوصفي التحليلي للوصول الى نتائج، وتم توزيع استبيان كوسيلة لجمع البيانات من مجتمع الدراسة، والمتمثل في القيادات الادارية في جامعة اجدابيا، ابتداء من رئيس الجامعة الى العمداء ورؤساء اقسام، البالغ عددهم (26) حيث تم توزيع الاستبيان وقد تم استرداد (24) استبيان بنسبة (92.30%)
وتوصلت الدراسة الى عدة نتائج اهمها ما يأتي:

وجود موافقة الى حد ما من قبل مجتمع الدراسة على مجال ابعاد جودة الحياة الوظيفية في جامعة اجدابيا بنسبة (71.45%). ايضا وجود موافقة الى حد ما من قبل مجتمع الدراسة على مجال فاعلية اتخاذ القرارات الادارية في جامعة اجدابيا بنسبة (62.15%).
وجود علاقة بين ابعاد جودة الحياة الوظيفية، وفاعلية اتخاذ القرارات الادارية في جامعة اجدابيا.
وجود تأثير ايجابي لجودة الحياة الوظيفية على فاعلية اتخاذ القرارات الادارية في جامعة اجدابيا.

وقد قُدمت مجموعة من التوصيات من اهمها ما يأتي:

الاهتمام بموضوع جودة الحياة الوظيفية في ادارة الموارد البشرية والاهتمام والمعرفة بكافة ابعادها من قبل ادارة الجامعة.
ضرورة قيام جامعة اجدابيا بتطوير انماطها القيادية السائدة فيها التي تدعم تطبيق جودة الحياة الوظيفية.
ضرورة التكفل بالتأمينات الصحية وغيرها للعاملين واسرهم في جامعة اجدابيا مما يعطي نتائج افضل للاستقرار والامان الوظيفي.
اشراك العاملين في جامعة اجدابيا في اتخاذ القرار لكي تزيد من درجة قبولهم للقرار الذي شاركوا بصياغته.
An evaluation of a final year multiple choice questions examination at Faculty of medicine-university of Benghazi
Authors: Alawgali Saleh M
Published: July 2024

Background: Multiple choice questions (MCQs) are widely used in medical education, they have the feature of sampling broad domains of knowledge efficiently and reliably. They represent one of the most important examination tools used in undergraduate and postgraduate medical examinations. Exam analysis is an assessment tool that provides important information about validity and reliability of test. Item analysis is used to analyze the difficulty and the discrimination ability of individual items and the total test scores. The purpose of this study is to examine the quality of one of the final exam papers, that is composed of single best of five MCQs, and to examine the correlation between the difficulty and discrimination index of each item. Subject and method: The authors collected the exam results of 425 students who set for the final exam at the end of the a academic year 2021- 2022. The exam consisted of 70 MCQs and was aiming to assess the students` knowledge, understanding, application and analysis of the subject matter. The test was analyzed regarding content validity and reliability of the test as a whole as well as the difficulty coefficient and discrimination coefficient for each item. Results: Out of the 425 students who set for the exam about 86% has passed (scored ≥ 60% of the total marks), the test reliability was excellent (0.91) and the mean difficulty index (P) was 75.22 ± 19.4 (easy exam). Out of the 70 items six (8.57%) had a poor discrimination (D < 0.1). When comparing the exam questions with the blueprint 90% of the topics of the subject materials were either over or under represented. About 77% of the exam questions were testing either students` knowledge or understanding. The correlation between the difficulty index and discrimination index was moderately positive which was statistically significant (0.633, P = 0.000). Conclusion: although the current study showed a good exam reliability, however the exam content validity was suffering from many weakness regarding the total number of the items, and distribution of the items according to the topics and the cognitive levels, therefore the number of exam questions should be increased and a blueprint should be developed for assessment. The overall exam difficulty was low as there were too many easy questions and this could impair both exam validity and reliability. The number of average and difficult questions should be considerably increased.
Optimization of Single-user Task Migration based on Improved DDPG
Authors: Ning Cao , Yang He , Can Hu
Published: July 2024

Aiming at the problems of slow convergence and unstable convergence of traditional reinforcement learning algorithms in minimizing computational cost on edge servers with random task arrivals and time-varying wireless channels, an improved DDPG algorithm (IDDPG) was proposed. The Critic network structure of DDPG was replaced by the Dueling structure, which converged faster by splitting the state value function into an advantage function and a value function. The update frequency of the Critic network was adjusted to be higher than that of the Actor-network to make the overall training more stable. The Ornstein- Uhlenbeck noise was added to the actions selected through the Actor-network to improve the algorithm exploration ability, and the action noise size was set in segments to ensure the stability of convergence. Experimental results show that, compared with other algorithms, the IDDPG algorithm can better minimize the computational cost and has a certain improvement in the convergence speed and convergence stability.
THE SCALE OF DIGITALIZATION: FROM TEXT TO SCIENTIFIC DATA
Authors: Сметана Владимир Васильевич
Published: July 2024

Данная статья рассматривает масштабы цифровизации знаний, охватывающей разнообразные формы информации, от традиционных текстов до современных научных данных. В статье анализируется концепция цифровизации знаний как процесса перевода знаний в цифровой формат для более эффективного хранения, доступа и использования. В этой статье, подробно описываются различные типы знаний, подвергаемые оцифровке, включая тексты, изображения, аудио, видео и научные данные, а также приводятся примеры ключевых проектов и инициатив в этой области, таких как Google Книги, Википедия и Интернет-архив. В заключение обсуждаются основные проблемы и возможности, связанные с масштабной цифровизацией знаний, подчеркивая необходимость решения технических трудностей, соблюдения авторских прав и преодоления цифрового разрыва для обеспечения равного доступа к знаниям для всего человечества.

This article examines the scale of digitalization of knowledge, covering a variety of forms of information, from traditional texts to modern scientific data. The article analyzes the concept of digitalization of knowledge as a process of transferring knowledge into a digital format for more efficient storage, access and use. This article describes in detail the various types of knowledge being digitized, including texts, images, audio, video, and scientific data, and provides examples of key projects and initiatives in this area, such as Google Books, Wikipedia, and the Internet Archive. In conclusion, the main challenges and opportunities associated with the large-scale digitalization of knowledge are discussed, emphasizing the need to solve technical difficulties, respect copyrights and bridge the digital divide to ensure equal access to knowledge for all mankind.
PROMOTION OF ANTI-CORRUPTION STANDARDS OF CONDUCT AS A TOOL TO COMBAT CORRUPTION
Authors: Вильгоненко Ирина Михайловна , Теске Дарья Алексеевна
Published: July 2024

Статья посвящена раскрытию антикоррупционных стандартов поведения граждан как инструментов борьбы с коррупцией и нахождению способов продвижения антикоррупционных стандартов поведения.

The article is devoted the disclosure of anti-corruption standards of behavior of citizens as tools for combating corruption and finding ways to promote anti-corruption standards of behavior.
ОСОБЕННОСТИ СТИЛЕЙ ПРИНЯТИЯ РЕШЕНИЙ В НЕОПРЕДЕЛЕННОЙ СИТУАЦИИ У ДЕТЕЙ С СИНДРОМОМ ГИПЕРАКТИВНОСТИ И ДЕФИЦИТА ВНИМАНИЯ
Authors: Сергиенко Алексей Анатольевич
Published: July 2024

Пилотное исследование стилей принятия решений в неопределенной ситуации у детей с СДВГ.

A pilot study of decision-making styles in an uncertain situation in children with ADHD.
THE CURRENT STATE OF ARTIFICIAL INTELLIGENCE: FROM INTEGRATION INTO EVERYDAY LIFE TO ETHICAL CHALLENGES
Authors: Сметана Владимир Васильевич
Published: July 2024

Данная статья посвящена актуальному состоянию искусственного интеллекта (ИИ) и его многогранному влиянию на современный мир. В статье анализируются ключевые тренды и достижения в исследованиях и разработках искусственного интеллекта, такие как экспоненциальный рост данных и вычислительной мощности, прогресс в области машинного обучения, а также смещение фокуса в сторону создания общего искусственного интеллекта (ОИИ). Особое внимание уделяется все более глубокой интеграции искусственного интеллекта в различные аспекты повседневной жизни, от потребительской электроники и здравоохранения до финансов и транспорта. В то же время поднимаются важнейшие этические и социальные вопросы, связанные с развитием искусственного интеллекта, такие как потенциальная утрата рабочих мест, проблемы предвзятости и дискриминации, защита конфиденциальности и риски, связанные с автономным оружием. В заключении подчеркивается необходимость ответственного подхода к развитию искусственного интеллекта, основанного на этических принципах и направленного на то, чтобы искусственный интеллект служил на благо всего человечества.

This article is devoted to the current state of artificial intelligence (AI) and its multifaceted impact on the modern world. The article analyzes key trends and achievements in research and development of artificial intelligence, such as exponential growth of data and computing power, progress in machine learning, as well as a shift in focus towards the creation of Artificial general intelligence (AGI). Special attention is being paid to the increasingly deep integration of artificial intelligence into various aspects of everyday life, from consumer electronics and healthcare to finance and transportation. At the same time, the most important ethical and social issues related to the development of artificial intelligence are being raised, such as the potential loss of jobs, problems of bias and discrimination, privacy protection and the risks associated with autonomous weapons. In conclusion, the need for a responsible approach to the development of artificial intelligence based on ethical principles and aimed at ensuring that artificial intelligence serves the benefit of all mankind is emphasized.
ВЛИЯНИЕ НЕСЪЕМНЫХ ОРТОДОНТИЧЕСКИХ АППАРАТОВ НА ПАРАМЕТРЫ СМЕШАННОЙ СЛЮНЫ
Authors: Солдатов В.С.
Published: July 2024

В настоящей работе по результатам проведенного исследования представлены данные о физико-химических показателях смешанной слюны у пациентов, проходящих ортодонтическое лечение на несъемной дуговой аппаратуре (брекет-системе) по сравнению с пациентами, посещающими стоматолога с профилактической целью. Целью данного исследования была оценка скорости выделения слюны, рН и буферной емкости до начала лечения и через 24 месяца после установки аппаратуры с использованием простого и доступного тест-набора.
ИНСТРУМЕНТЫ И МЕТОДЫ ГОСУДАРСТВЕННОГО ФИНАНСОВОГО КОНТРОЛЯ, ИСПОЛЬЗУЕМЫЕ ЦЕНТРАЛЬНЫМ БАНКОМ РОССИИ
Authors: Бородин А.Е.
Published: July 2024

В статье освещены вопросы деятельности ЦБ РФ в финансовом секторе государства. В наше время государственный контроль за финансами является одной из ключевых задач для стабильности и процветания экономики. Это система инструментов и методов, которые помогают отслеживать и регулировать денежные и финансовые операции. В рамках Российской Федерации Центральный банк играет особенно важную роль в этой системе, принимая различные меры для обеспечения экономической жизнеспособности.
ФИЗИЧЕСКОЕ РАЗВИТИЕ ДЕТЕЙ ДОШКОЛЬНОГО ВОЗРАСТА, ЗАНИМАЮЩИХСЯ ТХЭКВОНДО
Authors: Зобнин Е.А. , Рязанцев А.И. , Ячменев Н.В.
Published: July 2024

в настоящей работе рассмотрены вопросы физического здоровья детей дошкольного возраста. Как показывает научная литература, на протяжении последних десятилетий наблюдается тенденция к ухудшению показателей физической, функциональной, психо-эмоциональной, интеллектуальной подготовленности. В связи с чем изучение основных показателей здоровья детей является приоритетной задачей современной медицины и образования. В процессе исследования были изучены антропометрические (длина и масса тела, индекс Кетле-1, индекс Кетле-2) и физиометрические (кистевая сила правой и левой рук, кистевой индекс, жизненная емкость легких, жизненный индекс) показатели здоровья мальчиков в возрасте 4-5 лет. По результатам исследования оказалось, что наилучшим приростом показателей обладала экспериментальная группа.
ИЗУЧЕНИЕ СВЯЗЕЙ ОСОБЕННОСТЕЙ РЕПРЕЗЕНТАЦИЙ ОБ ОТНОШЕНИЯХ ПРИВЯЗАННОСТИ И ХАРАКТЕРИСТИК ПАМЯТИ У МЛАДШИХ ШКОЛЬНИКОВ ИЗ НЕПОЛНЫХ МАЛООБЕСПЕЧЕННЫХ СЕМЕЙ
Authors: Тишевской И.А. , Брижанина Т.В.
Published: July 2024

Целью исследования было выявление взаимосвязей особенностей памяти младших школьников из неполных малообеспеченных семей с типоспецифическими характеристиками их репрезентаций отношений привязанности к матери. Были изучены характеристики репрезентаций отношений привязанности к значимым взрослым у детей изучены особенности памяти, выявлены значимые различия в характеристиках памяти детей с различными репрезентациями отношений привязанности, а также разработана программа, нацеленная на улучшение показателей и характеристик памяти у младших школьников из неполных малообеспеченных семей, учитывающей различия репрезентаций отношений привязанности.
ДОСУДЕБНОЕ УРЕГУЛИРОВАНИЕ НАЛОГОВЫХ СПОРОВ, КАК СПОСОБ ЗАЩИТЫ ПРАВ НАЛОГОПЛАТЕЛЬЩИКОВ В ЭПОХУ ЦИФРОВИЗАЦИИ
Authors: Белоус Д.М.
Published: July 2024

На сегодняшний день перед налоговыми органами Российской Федерации поставлена важная задача по минимизации конфликтных ситуаций с налогоплательщиками, однако полностью избежать их невозможно. В связи с этим, не теряет своей актуальности досудебный порядок урегулирования налоговых споров, который позволяет не только обеспечить защиту прав налогоплательщика, но и избежать излишних финансовых, временных и репутационных потерь.
ШАХМАТЫ КАК ИНСТРУМЕНТ ОБРАЗОВАНИЯ ДЕТЕЙ МЛАДШЕГО ШКОЛЬНОГО ВОЗРАСТА
Authors: Пронин Е.А. , Абрамов Д.Н.
Published: July 2024

В статье рассматривается вопрос о введении образовательной программы «шахматы» в начальной школе. В настоящее время во многих регионах России реализуется проект «Шахматы в школах», проводимый Федерацией шахмат России и Фондом Геннадия Тимченко. Цель работы: изучение отношения сообщества родителей будущих первоклассников, детей младшего школьного возраста к обучению в школе игре в шахматы.
ПОДХОДЫ К ОБНАРУЖЕНИЮ ПОТЕНЦИАЛЬНЫХ ДЕФЕКТОВ В ПРОГРАММНОМ ОБЕСПЕЧЕНИИ
Authors: Николаев А.А. , Кожухов Н.К.
Published: July 2024

В данной статье рассматривается вопрос обнаружения потенциальных дефектов в программном обеспечении с целью предупреждения и смягчения негативных последствий. Работа включает анализ современных методов тестирования приложений, исследование процесса автоматизации поиска дефектов, а также разработку программы для автоматического обнаружения уязвимостей. Особое внимание уделяется статическому и динамическому анализу, а также использованию базы данных CVE для идентификации известных уязвимостей. Проведённый эксперимент подтверждает эффективность предложенных методов и алгоритмов, позволяя значительно сократить временные и финансовые затраты на разработку программного обеспечения.
Уголовное законодательство в условиях цифровой трансформации
Authors: Юмагулов И.Т.
Published: July 2024

в статье отмечается, что Россия, как и остальные государства планеты находится на сложном пути перехода от индустриального общества к информационному обществу, для которого характерны проникновение телекоммуникационных технологий во все сферы общественной жизнедеятельности. Не осталась в стороне и область уголовного судопроизводства. Интересным представляется вывод автора: применение новых технологий несомненно позволит сделать более конкурентным само содержание состязательного процесса. В любом случае решающим здесь остается человеческий фактор и степень юридической достоверности речевой и мыслительной деятельности, направленной на разрешение уголовно-правового спора. В каждом конкретном случае отправления правосудия остается и будет оставаться судья (присяжный заседатель).
Интернет и правовая культура
Authors: Ахметова А.Р.
Published: July 2024

Общепринятым стала в литературе точка зрения о начале процесса создания новой социально-коммуникационной электронной реальности. На этом фоне представители молодого поколения, в силу своей природной тяги к новому и неизбежного отторжения старого, стали питательной средой для насаждения Интернета, где они выступают не только в качестве безропотных слушателей, но и в кратчайшие сроки превращаются в активных поборников внедрения новых технологий в жизнь, активно продвигающего их не только среди своих сверстников, но и навязывающими их представителям старших поколений
RESULTS OF MOLECULAR DIAGNOSTICS OF ALLERGENS CAUSING ALLERGY AMONG THE POPULATION OF UZBEKISTAN
Authors: Alimova N.N. ,   Tashkent Medical Academy Republican Scientific Specialized Center Of Allergology, Tashkent, Uzbekistan, N.I. Vafoyeva ,   Tashkent Medical Academy Republican Scientific Specialized Center Of Allergology, Tashkent, Uzbekistan
Published: July 2024

Molecular allergological diagnostics is a modern method of determining sensitization, which allows to diagnose specific IgE with higher accuracy than traditional diagnostic methods, especially skin tests. This study was conducted in order to determine the types of allergenic molecules to which patients with allergic diseases are sensitive.
THE PRINCIPLES OF TRANSFERRING IDIOMS IN TRANSLATION FROM ENGLISH INTO UZBEK
Authors: G.I. Raximidinova ,   TUITFB, Department of Foreign Languages, English teacher, Uzbekistan
Published: July 2024

The given article copes with determining and systemizing the phonological and semantic transition of English phraseologies and idioms into Uzbek language by means of translation, taking into account the lingua-cultural aspects of two given languages, represented in the article as main objects of my work. The possibilities of adequate transmission of meanings and images, the mechanisms and principles of literary translation of idioms, and also the work includes suggestions for the translator on working with phraseological units.
PEDAGOGICAL ASPECTS OF CONTINUOUS DEVELOPMENT OF SPIRITUAL AND MORAL QUALITIES OF ADOLESCENT STUDENTS UNDER GLOBALIZATION
Authors: Ozoda Mamatkulova ,   Doctoral student of the Research Institute of Pedagogical Sciences of Uzbekistan named after T. N. Kori Niyozi, Uzbekistan
Published: July 2024

This article describes the pedagogical aspects of the continuous development of the spiritual and moral qualities of adolescent students in the context of globalization and its importance for today, as well as draws relevant conclusions on this topic.