bluuebunny/crossref_metadata_2025 huggingface dataset:
Serum Biomarker Panel for Rapid Early Diagnosis of Lung Cancer
Authors: Wu Shucai , Zhang Jiawen , Wei Hongyan , Liu Ying , Dai Xianli , Xue Jinyu , Shen Ting , Liu Xinyan
Published: May 2022

Background:

Lung cancer is the leading cause of cancer death in most countries. Although
early diagnosis and treatment critically influence prognosis, lung cancers are generally only discovered
in the late stages of the disease.

Objective:

Widely-used screening and diagnostic methods are not suitable for preventive screening,
and high-throughput technologies based on serum biomarkers are needed.

Methods:

We screened 501 serum samples, including 224 lung cancer (LC), 126 disease control (DC),
and 151 healthy donor (HC) samples for new serum autoantibodies as biomarkers in the early diagnosis
of lung cancer. In phase I, we used HuProtTM microarrays to perform preliminary serum antibody
screening on 24 LC and 24 HC samples. In phase II, we screened 60 LC, 60 DC, and 60 HC serum
samples using focused arrays constructed with 22 of the candidate autoantibody biomarkers screened
out in phase I.

Results:

After data modeling and validation, we selected four potential early LC protein biomarker
candidates, IL2RB, CENPB, TP53, and XAGE1A, with individual specificities >90% and sensitivities
ranging from 21.2% to 32.2%. These four biomarkers had a specificity of >90% and a sensitivity
of >65.5% for early LC when they combined in a panel. Further evaluation of these four biomarker
candidates using ELISA assays and 273 serum samples (140 LC, 66 DC, and 67 HC) gave similar results
(specificity of >91.7%, sensitivity >61.43%).

Conclusion:

IL2RB, CENPB, TP53, and XAGE1A combined biomarker panel holds potential for rapid
screening and improving the diagnosis of early-stage LC, thus potentially also improving its prognosis.
In-silico Studies, Synthesis, and Evaluation of Anti-inflammatory Activity
of Novel Pyrimidine Scaffold
Authors: Munde Ganesh , Menghani Sunil , Rarokar Nilesh , Kerzare Deweshri , Chittur Md. Asif Iqbal , Khedekar Pramod
Published: May 2022

Background:

The heterocyclic nucleus pyrimidine is present in several natural and synthetic
chemical analogues and has proved its broad medicinal applications. Further, pyrimidine in the form of
parent structure or basic skeleton of RNA and DNA is involved in controlling the immune functioning,
and in turn, inflammatory reactions.

Objective:

The objective of the present study is to evaluate some novel pyrimidine analogues for antiinflammatory
action.

Methods:

Molecular docking studies of Indomethacin and selected analogues were carried out with the
COX-2 enzyme (PDB: 4ZOL). The synthesis of derivatives of 4-Phenyl-6-(phenylamino)pyrimidine-2-ol
derivatives was begun by following Perkin condensation between substituted acetanilides and substituted
aromatic aldehydes to yield an intermediate, which in turn produces the required nucleus for treatment
with urea. All synthesized compounds were evaluated for in vivo and in vitro anti-inflammatory activity.

Results:

The docking interaction reflects a good dock score when compared with indomethacin, a potent
Anti-inflammatory drug. In the majority of the compounds, pyrimidine was able to form hydrogen bonding
while the rest of the part was involved in hydrophobic bonding. All compounds were synthesized in
good yield and confirmed by physical and spectral studies. In vitro studies showed that compounds 5a and
5e were better at controlling inflammation than the conventional treatment Antipyrine, while in vivo data
showed that compounds 5a, 5c, 5e, and 5h were better at controlling inflammation than the standard drug
Antipyrine.

Conclusion:

The compound with more than one electron releasing group on the aniline moiety of pyrimidine
yields a decent result in the synthetic and experimental studies, but the absence of an electron withdrawing
group favours stronger anti-inflammatory activity on the target.
Virtual Screening, Molecular Docking, and Physiochemical Analysis of
Novel 1,3-diphenyl-2-propene-1-one as Dual COX-2/5-LOX Inhibitors
Authors: Mittal Roopal , Sharma Shailesh , Mittal Amit , Kumar Shubham , Kushwah Ajay Singh
Published: May 2022

Background:

Chronic inflammation is usually combated with non-steroidal anti-inflammatory
drugs (NSAIDs). However, long-term use of NSAIDs causes side effects comprising gastric ulceration,
abdominal discomfort, lack of anti-thrombolytic activity, and myocardial infarction. Emerging reports
indicate alteration of arachidonic acid metabolism, via cyclooxygenase and lipoxygenase pathways, being
investigated as potential anti-inflammatory agents. There is a dynamic balance shift toward lipoxygenase
on cyclooxygenase inhibition, therefore there is a need to identify naïve dual COX-2/5-LOX inhibitory
agents with better therapeutic and minimal side effects.

Objective:

The current research focused on identifying a prospective natural candidate molecule (1,3-
diphenyl-2-propene-1-one derivative) as a dual COX-2/5-LOX inhibitor by using structure-based
database screening, molecular modelling, and in-silico ADMET analysis.

Methods:

Virtual screening using the ZINC database, molecular docking of potential compounds, and
ADME analysis of hit compounds were performed.

Results:

A virtual library of 116 chalcone-based molecules was screened out. The molecules were docked
for COX-2 (PDB ID-3LN1) and 5-LOX (PDB ID-3V99) enzymatic active pockets and resulted in
compounds C96, C8, C83, C45, C20 better than zileuton. The potent compounds and zileuton showed
good binding affinity in the range of -8.0 to -8.7Kcal/mol in the COX-2 and -7.0 to -8.7Kcal/mol in the 5-
LOX active site respectively. These compounds were further subjected to ADME analysis giving two
plausible lead compounds C45 and C64 following ideal pharmacokinetic properties.

Conclusion:

The research work provides abundant opportunities to explore computational and medicinal
research areas which will facilitate the development of novel dual COX-2/5-LOX inhibitors in future
experimental studies.
Assessment of Binding Site and Development of Small Molecule Inhibitors Targeting Epidermal Growth Factor Receptor Mutations in Non-Small Cell Lung Cancer (NSCLC)
Authors: Wakte Pravin S. , Karnik Kshipra S. , Sarkate Aniket P. , Rajhans Aishwarya P.
Published: May 2022

Background:

Mutations occurring in the epidermal growth factor receptor of the tyrosine kinase family concerned with non-small cell lung cancer have been specifically targeted.

Objectives:

The library design and R-group enhancement technique have been carried out on the preexisting marketed drugs to increase the binding affinity of the designed novel compounds. The screening of compounds was done using a flexible docking protocol.

Methods:

Molecular docking studies provided information about binding pockets and interactions of molecules with the mutant (PDB: 4I1Z) as well as wild-type (PDB: 4I23) EGFR enzymes. The flexible docking was well supported by ADMET and molecular dynamic simulation studies.

Results:

On the basis of docking score and protein-ligand interactions, the highest-scoring molecule was selected for molecular dynamics simulation, providing a complete insight into the ligand interaction and saturation

Conclusion:

The screened molecules can act as potential EGFR inhibitors in the management of drug resistance.
Assessment of Alternative Medicine Use, Costs, and Predictors of
Medication Adherence among Diabetes Mellitus Patients in Palestine
Authors: Mosleh Rami , U’wais Ala’ , Hamdan Anas , Ghanim Mustafa , Jarrar Yazun
Published: May 2022

Background:

Diabetes Mellitus (DM) is considered the fourth leading cause of death in
Palestine, with a prevalence of 9.1% in patients aged 20-79 years, and has increased to 20.6% in 2020.

Aims:

This study aims to estimate DM costs, compare DM total health care cost among patient
characteristics and DM management (e.g. anti-diabetic medications and alternative medicine), as
well as assess MA and its predictors including patient characteristics, DM management, alternative
medicine use, and DM costs.

Methods:

A cross-sectional study was conducted for the past one year among 479 diabetic patients,
selected by convenience sampling and snowball sampling methods via electronic post of an online
questionnaire, including a web link to the questionnaire page in a Google Form via email or public
social media pages and applications. Data on patients’ socio-demographic and clinical characteristics,
medication profile, use of medicinal plants as alternative medicine, costs, and Medication Adherence
(MA) were collected. The Statistical Package for Social Sciences (SPSS v. 25) was used to
perform a descriptive, Kolmogorov-Smirnov test, univariate analysis, Mann-Whitney or Kruskal-
Wallis test, multiple linear regression, binary logistic regression, and multiple logistic regression
analysis. A p-value < 0.05 was considered statistically significant.

Results:

More than half of the participants were male and living in villages (50.7%, 59.1%, respectively).
Approximately 51.4% received Oral Hypoglycemic Drugs (OHDs) and only 16.1% received
insulin. The participants receiving ≤3 medications daily acquired the highest percentage
(55.7%), and less than half received medicinal plants as an alternative medicine for the management
of DM. The estimated total DM health care cost per year incurred by patients and family
members was Israeli Shekel 988,276 (US Dollar 307,590). More than half of the participants were
considered adherent with the Eight–Item Morisky Medication Adherence Scale (MMAS–8) score
≥6. It is noteworthy that the use of alternative medicine was significantly associated with total
health care cost and MA. Furthermore, DM duration was significantly associated with MA. These
results are worth taking into consideration.

Conclusion:

This study reflects the need for strengthening the patient-health care professionals’ relationship,
and to enhance the role of preventive education, and the importance of awareness about MA,
DSCMBs, and the use of alternative medicine based on evidence-based strategies to improve MA,
glycemic control, meanwhile reducing the costs incurred by patients and family members.
Electronic Method (Pro-Kin) for Improving and Speeding Up the
Recovery After Ankle Sprain
Authors: Marvulli Riccardo , Ianieri Giancarlo , Pignatelli Giovanni , Santagati Dario , Ranieri Maurizio , Megna Marisa
Published: May 2022

Background and Objective:

Ankle sprains, very common injuries occurred especially
during sports activities, are mainly caused by indirect trauma, which influences exaggerated stress
exceeding the strength of stabilization mechanisms. Up to 85% of such injuries result from a sudden
flexion and inversion of the foot. In this study, we analyzed the effectiveness of the platform
Pro-kin, an innovative system that has given us the possibility to combine the functionality of the
older proprioceptive boards with very accurate software in order to improve and accelerate the recovery
after ankle injuries.

Methods:

30 patients with moderate ankle sprain outcomes in two groups (A and B) were included
in this study. Group A was only treated with proprioceptive exercises for 3 weeks, while the group
B was trained with the innovative Pro-kin. In both groups, we evaluated VAS scale, the ratio between
the number of circumductions performed by the injured foot and the time spent on doing
them and the percentage of load among the injured and the healthy foot in statics and dynamics
with electronic baropodometry. Our data has been collected at t0 (beginning of study), t1 (one
week later), t2 (two weeks later), t3 (one month later), t4 (two months later), and then analyzed by
the two-way analysis of variance (2-way ANOVA) test.

Results:

At t0 no statistical differences of pain in the 2 groups (3.3 and 3.4); the values were similar,
as well as at time t1, t2, t3 and t4. Therefore we deduce that Pro-kin treatment is not painful.
The number of circumductions performed was definitely better in B group since the first week; for
the A group the values considerably increased only at t3 (one month later). Comparing the load percentages
on two feet detected by the electronic baropodometer in statics and in dynamics, we deduced
that the patients of A group tend to lean mostly on the healthy foot than B group.

Conclusions:

This study demonstrates that new technological resources (such as Pro-kin) may be
helpful to improve and speed up the recovery of ankle sprain in athletes.
Tomato as a Natural Source of Dyes in the Food Industry: A Patent Data
Analysis
Authors: de Lima Silva Vanessa , Leite Bruna Santos , do Espírito Santo de Jesus Fabiane , Martins Lissa Daltro , Assunção Larissa Santos , Leal Ingrid Lessa , Colauto Nelson Barros , Colauto Giani Andrea Linde , Souza Machado Bruna Aparecida , Ferreira Ribeiro Camila Duarte
Published: May 2022

Background:

Foods that promote health benefits are being increasingly used. Innovative
techniques, such as nanotechnology, have been used to improve functional properties, sensory characteristics,
or the conservation of foods.

Objective:

The objective of this study was to identify the technological domain of patents for tomato
products with or without nanotechnology and elucidate the technological advances associated with the
recent use of tomatoes as a natural food dye in the food industry by exploring patent documents.

Methods and Results:

The search was conducted using the Espacenet and INPI databases. There was
an increase in patent document applications employing nanotechnology in 2013, with a peak between
2017 and 2018. China is the lead country in the number of patent applications. In Brazil, the patent applications
are variable, and the food industry is most involved in studies on tomatoes as a natural food
dye. Most patent deposits using nanotechnology were from companies, and the main sources of the patent
application were the food and pharmaceutical industries.

Conclusion:

There is an increasing trend for the use of tomatoes as natural food dyes, produced with or
without nanotechnology, and number of patents filed yearly. New technologies are being developed in
several application areas.
A Detailed Insight into Nanostructured Lipid Carriers: A Versatile Drug
Delivery System
Authors: Jain Neha , Ghosh Samarjit , Tiwari Triveni , Nagaich Upendra
Published: May 2022

The advent of technology provides a solution to various drug delivery-related problems by
undertaking the development of a better drug delivery system, i.e., nano-sized drug delivery systems as
they have shown huge prospects for effective delivery of drugs in the body. Nanostructured lipid carriers
(NLCs) are such type of novel drug delivery system in which lipids of both solid and liquid types
are used as a core for the disorganized matrix, which prevents the solid lipid crystallization and increases
drug payload. They are generally composed of solid and liquid lipids, emulsifiers, drugs, and
other various additives, which are selected based on purity, chemical stability, the concentration of materials
required, compatibility, biodegradability, processing type, cost, and their regulatory status. Placing
bioactives into nanostructured lipid carriers (NLCs) has enhanced pharmacokinetic characteristics
by increasing therapeutic functionality and prolonging release from these carrier systems. In our opinion,
the search involves two steps viz. fabrication strategies, production methods, and the impact of various
types of substances on them, as well as the release mechanism and targeting modalities. In addition
to other applications, the use of NLCs in gene therapy has marked a promising path for new and
better drug delivery systems. Further development of various dosage forms using NLCs, like NLC
based hydrogels, is being done for improving the overall aesthetic properties, leading to the desired
therapeutic effect of the incorporated active. This review highlights several elements of NLCs, such as
structural model and types, excipients utilized, factors affecting NLC production, preparation techniques,
characterization, current applications, patents, challenges, and opportunities.
Coir Pith Lignin as a Reliable Bio-Source for Carbonaceous Nano-
Structures: Extraction and Characterization
Authors: Sherafuddeen Fathima , Deeraj Battula Durga Siva , George Gejo , Joseph Kuruvilla
Published: May 2022

Background:

This paper signifies using coir pith lignin as a cheap and reliable carbon source for preparing bio-based carbonaceous material.

Objective:

The coir pith is selected as it is abundantly available and has a very high lignin content of 38-59.5%. The soda extraction process does the extraction of lignin from coir pith with a yield of 45%.

Method:

This extracted lignin is then subjected to a different procedure to transform it into carbon nanofibers with an ID/IG ratio of 0.35 and carbon fillers with a high surface area of 1089.1 m2/g without the presence of an activating agent.

Results:

Thus prepared carbonaceous fillers are potential reinforcements for polymer matrices as these fillers may provide sufficient mechanical and thermal stability to the composites.

Conclusion:

Furthermore, due to their excellent electrical conductivity, 0.221 S/cm, the carbonaceous nanomaterials are suitable for multifunctional composite applications. This is the first work based on coir pith lignin as a carbon precursor to the best of our knowledge.
Contemporary Approaches to Analyze Non-stationary Time-series:
Some Solutions and Challenges
Authors: Dixit Ankit , Jain Shikha
Published: May 2022

Enhancement of technology yields more complex time-dependent outcomes for better understanding and analysis. These outcomes are generating more complex, unstable, and high-dimensional data from non-stationary environments. Hence, more challenges are arising day by day to fulfill the increasing demand for future estimation. Thus, in this paper, an extensive study has been presented to comprehend the statistical complexity and randomness of non-stationary time series (NS-TS) data at the atomic level. This survey briefly explains the basic principles and terms related to non-stationary time series (NS-TS). After understanding the fundamentals of NS-TS, this survey categorized non-stationarity into groups and their subgroups based on a change in statistical behavior. It is followed by a comprehensive discussion on contemporary approaches proposed by researchers in each category of non-stationarity. These algorithms include clustering, classification, and regression techniques to deal with different types of domains. Every category of non-stationarity consists of a separate table to draw some advantages and disadvantages of existing approaches. At the end of each non-stationarity type, a short discussion and critical analysis have been done. In the conclusion section, it observed that this research sphere still has so many open challenges that need to be addressed and demand more exploration. Furthermore, it discusses the possible solution of improvisation in future research.
Kaolinite-Starch based Nano-Composites and Applications
Authors: Gupta P.
Published: May 2022

Starch and kaolinite are low cost and easily available materials used in different domains. At the same time, they form biodegradable nanocomposites (NCs), attractive and important substitutes for non-biodegradable materials which are the major source of environmental pollution. Kaolinite-starch based NCs are promising materials because they possess good mechanical and thermal properties and water resistance capacity etc. Properties are dependent on the filler particles orientation, nature of kaolinite and starch interaction, filler–matrix interface and filler dosages. The properties also depend on the anisotropy of the particles of fillers, their surfaces and the filler dispersion. These NCs have enormous applications specially in food packaging, films, paper, etc. It is used in environmental remediation. In this chapter an overview of methods of preparation, characterization and applications of kaolinite-starch based nanocomposites have been discussed.
Enzyme Immobilized Nanoparticles Towards Biosensor Fabrication
Authors: Jeevanandam J.
Published: May 2022

In recent times, nanomaterials with semiconductor properties are introduced as a potential transducer in biosensors, which can be credited to their intrinsic, elevated surface-to-volume proportion, enhanced sensitivity, and improved surface properties. The surface properties of nanomaterials have made them a significant transducer matrix towards the immobilization of bioreceptors, which eventually enhances the identification threshold and the biosensor sensing capability. Several nanomaterials, such as polymer, metal oxide, metal and carbon-based, as well as nanocomposites, are used towards transducer manufacturing, eventually being incorporated in the biosensors. The current chapter lays an outline with respect to biosensors that are fabricated with nanomaterials as a transducer, where enzymes acting as a bioreceptor, are immobilized on their surface. In addition, the biosensing mechanisms of the enzyme immobilized nanomaterials, their efficiency, detection limit, and sensitivity, are also discussed.
Biomedical uses of Enzymes Immobilized by Nanoparticles
Authors: Naqvi S.A.R.
Published: May 2022

Immobilized enzymes are now a significant and appropriate area of modern technologies. Immobilization of enzymes on nanoparticles (NPs) especially magnetic nanoparticles (MNPs) not only increase the stability of the enzymes by protecting the active site but also facilitates the separation mode. Immobilized technology is considered effective in context of running cost to exercise immobilized enzymes technique. Nowadays, variety of magnetic nanoparticles are available such as chitin-chitosan magnetic nanoparticles, Fe3O4 magnetic nanoparticles, bacteriophages T4 capsid novozym-435 etc. which are quite fit for loading enzymes and to use fruitfully. The main focus in this piece of work is that how immobilized enzymes are helpful in different biomedical uses and what kind of enzymes and nanoparticles could be hyphenated to take advantage in health care sectors. Different method of enzymes immobilization will also be discussed in details including both physical methods and chemical methods of loading enzymes on nanoparticles.
The effect of CPRT on North Korean fugitive mothers' empathy ability and their children's problem behavior
Authors:   Department of Child Welfare, Namseoul University, Cheonan, South Korea, Kim Minkyeong
Published: May 2022

The present research utilizes the statistical program SPSS 23.0. First, the non-parametric Mann-Whitney U test examined the homogeneity of the socio-demographic characteristics of the experimental group and the control group. The Mann-Whitney U Test and the Wilcoxon Singed-Rank Test were conducted through a nonparametric statistical method. The results are summarized. First, CPRT improved the empathy of the experiment group compared with the control group. Second, many positive behavioral changes were observed in the process of their therapy. They became more accepting of the emotion of their children and less playful and more supportive of the play-focusing program. Third, it was found that the experiment group’s behavior problems of the children were improved in contrast to those of the control group. The CPRT appeared to be significant in improving these behavior problems in children. The results of the analysis are expected to provide base data that can be used in the field to help young children increase such abilities.
The Importance of Digital Technologies in the Logistics of Seaports
Authors:   Vladivostok State University of Economics and Service, Zhokhova Valentina V. , Blyudik Angelina R.
Published: May 2022

Relevance. The article examines the impact of digitalization on the logistics activities of seaports. Optimization of the working operations of seaports is inextricably linked with the efficient movement and processing of a large amount of information between all participants in the logistics chain. The use of electronic document management, "digital twins", digital information platforms are considered in this article as one of the elements of modernization of logistics of seaports. In the Russian Federation, the issues of competitiveness and improving the efficiency of seaports, including using digital technologies, increasing the level of their innovation are particularly relevant. What is the significance of their application in the field under study, is it due to the introduction of "smart" network systems or the possibility of organizing work on a new basis? The purpose of the study is the need to identify the advantages of using digital technologies in the management system of logistics activities of seaports on the example of the Primorsky Territory. Objectives: to conduct a scientometric analysis of scientific articles studying the subject area; to analyze the main approaches to the definition of "digital technologies in logistics"; to identify the advantages of using digital technologies in logistics; to determine their significance for the development of logistics activities in seaports. Methodology. The research methodology is based on an integrated approach, including the analysis of scientific and normative literature, the study of international practice. The methods of comparative and system analysis are used to investigate the logistics activities of the seaports of the region. Results. The paper evaluates the results of a theoretical discussion in the study of the concept of digital technologies in logistics activities. The results of the study of the logistics management system of seaports using digital technologies on the example of the Primorsky Territory in the period 2020-2021 are presented. Conclusions. The main results of the research in the field of digitalization of logistics systems of transport and cargo flows can make a certain contribution to the development of theoretical knowledge in this field. And also to help the managers of seaports in the modernization of logistics activities.
"Color Revolutions" in the Post-Soviet Space: Socio-Economic Prerequisites and Consequences
Authors:   Southwest State University, Kuzmina Violetta M. , Parkhomchuk Marina A.
Published: May 2022

Relevance. The "color revolutions" that literally filled the entire post-Soviet space in the early 2000s are based not only on political roots, but to a large extent on a socio-economic basis, which manifested itself in the miserable existence of citizens of the post-Soviet space who saw the reason for their economic difficulties in power, in its inability to govern the state at this stage. The purpose is to reveal the influence of socio-economic factors on the process of the "color" revolutions on the example of such countries as Georgia, Ukraine, Kyrgyzstan. Methods. Objectives: consider the dynamics of the main macroeconomic indicators of the EU and the US from 2015 to 2020; to study and visualize the dynamics of GDP growth, GDP in PPP per capita, inflation in the EU member states for 2016–2020; investigate the dynamics of the total US government debt for 2015-2020. Metodology: the method of statistical and critical analysis of data from world agencies (Solidarity center, Center for International Private Enterprise CIPE, International Republican Institute, National Democratic Institute for International Affairs, National Security Council); the method of comparative analysis was used to compare the socio-economic causes and consequences of the “color revolutions” in Georgia, Kyrgyzstan and Ukraine. Results. "Color revolutions" in the post-Soviet space were developed according to the same technologies developed in the West and tested in the countries of the Near and Middle East during the period of "velvet" revolutions. The only basis for their course, which ensured their success, was the worse state of the country's economy, the poverty of the bulk of the population and the presence of youth groups financed from the West to incite protest and sometimes nationalist sentiments. Conclusions. After the events in Georgia and Ukraine in Russia, at the level of high-ranking government officials, decision-makers gradually formed a point of view according to which "revolutionary events" in the CIS republics are causing real damage to Russian national interests in the post-Soviet space. Key words: Ukraine, Kyrgyzstan, Georgia, post-Soviet space, "color revolutions".
Transformation of Employment Processes
Authors:   Southwest State University, Mamontova Svetlana V. , Malsagov Magomed K.
Published: May 2022

Relevance. The active introduction of digital technologies increases competition in the labor market, increasing the requirements for employees and employers, their professional competencies. The use of Internet resources and digital technologies provides ample opportunities in the process of activity, but with all the advantages, there are also disadvantages concerning the risks of social and labor relations that require research on remote employment. The purpose is to identify the problems, more precisely, advantages and disadvantages associated with new forms of employment caused by the transformation of the economic system on the basis of the conducted research. Objectives: To analyze the modernization of employment in the conditions of the current economic situation, to study the factors of the development of the remote form of employment of the labor market, to consider the policy in the field of non-standard employment, as well as the mechanisms of its regulation. Methodology: content analysis of leading specialists and the legislative framework in the field of employment, systematic and logical analysis, processing and description of the research results. Results. The article studies the development of non-standard forms of employment, considers changes in labor legislation, problems that characterize social and labor relations, methods of organizing remote labor. A comparative analysis of the transformation of employment of the population, including the problems of social and labor relations, is given. Conclusions. In the process of globalization of the economic system that is at a transformational stage of development, when we are witnessing the transition to post-industrialism, informatization and globalization, the formation of a unified world information and communication system using Internet resources, the content of work that requires in – depth analysis and study is radically changing.
Investment Image Characteristics in the Factor Space of the Region in the Context of Ensuring Economic Security
Authors:   Southwest State University, Starovoit Roman V. , Emelyanov Sergey G. , Afanasyeva Lubov V.
Published: May 2022

Relevance. In the system of economic security, the problem of investment provision is one of the key ones, since the formation of the investment process in the region is largely determined by the peculiarity of the economic mechanism for regulating investment activity, the emerging trends in demand for financial, credit and monetary resources, the presence of business structures that contribute to the implementation of the objectives of regional investment policy. For the normal functioning of the economic security system of the region, material resources are necessary. However, in the conditions of fierce competition for development resources, it is important to search for other factors, namely non-material ones, such as image characteristics. In the conditions of objectively existing resource opportunities of the regions, it is the practice of forming a positive image that is considered as a necessary component of the system of strategic development in the competition for investment resources. The purpose of the study: to identify the image characteristics in the composition of the factor space of the region, formed by national ratings. Objectives: to determine the information and communication model of the process of forming the image of the region, to decompose the image characteristics in the factor space of the region in the system of ensuring economic security, to build profiles of investment risk and investment potential of the Kursk region. Methodology. General scientific methods were used in the study: theoretical and methodological analysis of sources, illustrative-graphic, abstract-logical. Results. It is established that the investment image characteristics in the factor space are the competitive advantages of the region and are considered as an intangible factor that allows stimulating the socio-economic development of the territory. Conclusions. The integrated assessment of territories implemented in ratings and indexes serves as a reference point for decision-making by target groups. Effective attraction of investment resources is considered as a necessary condition for the implementation of strategic initiatives, so the parameters involved in the formation of the investment image of the region should be linked and coordinated with the objectives, resources and deadlines for achieving the target indicators and indicators of state programs.
Resource Potential of the Region as the Basis for Innovative Development of Bioeconomy Sectors
Authors:   Southwest State University, Bessonova Elena A. , Rudenko Ivan R.
Published: May 2022

Relevance. Against the background of the active development of biotechnologies around the world, research aimed at improving methods for determining the place and role of regions in the unified economic and biotechnological space of the country, by assessing their resource potential and opportunities for innovative development of bioeconomics industries, is becoming particularly relevant. The purpose of this study is to clarify and improve the methodology for assessing the resource potential of the region from the point of view of the possibilities of innovative development of bioeconomics industries. Objectives: to review approaches to assessing the resource potential of the region; to present a methodology for assessing the resource potential in the form of a single set of tools, methods, forms of assessment, as well as the procedure and conditions for its application; to propose and characterize the levels of the resource potential of the region, as well as to test the methodology within the regions of the Central Federal District. Methodology. The theoretical and methodological basis of the research was the methods and approaches presented in the works of scientists in the field of resource potential research. In the course of the scientific research, empirical, theoretical, statistical methods and methods of graphical representation were used. Results. The author proposes a methodology for assessing the resource potential of the region as a single set of tools, methods, forms of assessment, as well as the procedure and conditions for its application. The proposed methodology is aimed at determining the level of the resource potential of the regions and the possibilities of implementing biotechnological complexes in the studied territory. Conclusions. The paper formulates and substantiates the methodological aspects of assessing the resource potential of the region as the basis for the innovative development of bioeconomics industries, which make it possible to make a rating of regions in the form of a list of potential territories capable of implementing a biotechnological complex.
Determination of Potassium Bromate in Bread Brands in Sulaimani City, Kurdistan-Iraq
Authors: Hama Abdullah
Published: May 2022

Bread is the most consumed and staple food in many countries worldwide. It is made from dough of flour such as wheat and barley, and water. It usually contains flour improver potassium bromate (KBrO3) which is used by bakers. However, many studies have confirmed the deleterious effects of KBrO3 on human health. Therefore, this study aimed to determine the rate of KBrO3 in five main types of bread in Sulaimani city, Kurdistan-Iraq. The duration of the study was from August 2021 to November 2021. Thirty bread samples were collected from five main products that are extremely consumed by Kurdish citizens. The bread-type products were bakery bread (Nani frn), white hamburger bread (Samun), white bread known as Kurdish bread (Nani Hawrami), pizza, and brown barley bread. Single beam UV–visible spectrophotometer APEL-303 was used for the quantification of KBrO3 in bread samples. The results found that all 30 samples were had KBrO3 residues in their products with different concentrations. Samples of brown barley bread were having the least content of KBrO3 while samples from pizza dough were having the highest concentration of KBrO3. The present study concludes that all bread samples from five major bread types had potassium bromate above the permitted levels allowed by the United States Food and Drug Agency (FDA).
Measuring Health-Related Quality of Life With Multimodal Data: Viewpoint
Authors: Clay Ieuan , Cormack Francesca , Fedor Szymon , Foschini Luca , Gentile Giovanni , van Hoof Chris , Kumar Priya , Lipsmeier Florian , Sano Akane , Smarr Benjamin , Vandendriessche Benjamin , De Luca Valeria
Published: May 2022

The ability to objectively measure aspects of performance and behavior is a fundamental pillar of digital health, enabling digital wellness products, decentralized trial concepts, evidence generation, digital therapeutics, and more. Emerging multimodal technologies capable of measuring several modalities simultaneously and efforts to integrate inputs across several sources are further expanding the limits of what digital measures can assess. Experts from the field of digital health were convened as part of a multi-stakeholder workshop to examine the progress of multimodal digital measures in two key areas: detection of disease and the measurement of meaningful aspects of health relevant to the quality of life. Here we present a meeting report, summarizing key discussion points, relevant literature, and finally a vision for the immediate future, including how multimodal measures can provide value to stakeholders across drug development and care delivery, as well as three key areas where headway will need to be made if we are to continue to build on the encouraging progress so far: collaboration and data sharing, removal of barriers to data integration, and alignment around robust modular evaluation of new measurement capabilities.
Assessing the Initial Validity of the PortionSize App to Estimate Dietary Intake Among Adults: Pilot and Feasibility App Validation Study
Authors: Saha Sanjoy , Lozano Chloe Panizza , Broyles Stephanie , Martin Corby K , Apolzan John W
Published: May 2022

Background

Accurately assessing dietary intake can promote improved nutrition. The PortionSize app (Pennington Biomedical Research Center) was designed to quantify and provide real-time feedback on the intake of energy, food groups, saturated fat, and added sugar.

Objective

This study aimed to assess the preliminary feasibility and validity of estimating food intake via the PortionSize app among adults.

Methods

A total of 15 adults (aged 18-65 years) were recruited and trained to quantify the food intake from a simulated meal by using PortionSize. Trained personnel prepared 15 simulated meals and covertly weighed (weigh back) the amount of food provided to participants as well as food waste. Equivalence tests (±25% bounds) were performed to compare PortionSize to the weigh back method.

Results

Participants were aged a mean of 28 (SD 12) years, and 11 were female. The mean energy intake estimated with PortionSize was 742.9 (SD 328.2) kcal, and that estimated via weigh back was 659.3 (SD 190.7) kcal (energy intake difference: mean 83.5, SD 287.5 kcal). The methods were not equivalent in estimating energy intake (P=.18), and PortionSize overestimated energy intake by 83.5 kcal (12.7%) at the meal level. Estimates of portion sizes (gram weight; P=.01), total sugar (P=.049), fruit servings (P=.01), and dairy servings (P=.047) from PortionSize were equivalent to those estimated via weigh back. PortionSize was not equivalent to weigh back with regard to estimates for carbohydrate (P=.10), fat (P=.32), vegetable (P=.37), grain (P=.31), and protein servings (P=.87).

Conclusions

Due to power limitations, the equivalence tests had large equivalence bounds. Though preliminary, the results of this small pilot study warrant the further adaptation, development, and validation of PortionSize as a means to estimate energy intake and provide users with real-time and actionable dietary feedback.
Impact of Government policy and Infodemic Attitudes on Public Action during COVID-19 Pandemic (Preprint)
Authors: Wang Hsin , Wei Chih An , Liu Yu Hsin , Lu Chun Jui , Chang Luan Yin , Lai Fei Pei
Published: May 2022

BACKGROUND

COVID-19 has caused millions of deaths since 2020 in the world. Governments in different countries have implemented a variety of policies to prevent the outbreak . At the same time, whether people obey these regulations also plays a role in the practice of policies.

OBJECTIVE

The aim of this study is to explore the relationship between government policies, people’s beliefs and actions about policies of COVID-19 pandemic control.

METHODS

We utilize the data from the Facebook surveys, the Oxford Covid-19 Government Response Tracker and Taiwan Ministry of Health and Welfare. After the validation of these data, we applied the Pearson correlation coefficient and Spearman correlation to investigate the relationship among policy, public action, mental health, channels of information receiving, public attitudes towards these channels, and COVID-19 incidence/death rate.

RESULTS

Our results indicated that policies not only influence people’s actions, but also their health. Stricter policies can greatly decline people’s outdoor activity and make them keep social distance. However, these strict restrictions also cause people’s anxiety and depression. Meanwhile, how the information related to COVID-19 is transmitted and what attitudes that people have towards these media can also affect their behavior on epidemic prevention. Our results further show that some behaviors are strongly related to the decrease of COVID-19 incidence and death cases, especially wearing masks and keeping social distance.

CONCLUSIONS

This research provides evidence that government policy and infodemic attitudes can have impacts on public action, and these impacts are related to the extent of COVID-19 pandemic control. Since the data we used are open and global, the method in this research can apply worldwide.
Intelligent physical robots in healthcare: a systematic literature review (Preprint)
Authors: Huang Rong , Suomi Reima , Li Hongxiu , Peltoniemi Teijo
Published: May 2022

BACKGROUND

Various intelligent physical robots based on artificial intelligence have been developed and it has been argued that they will bring about dramatic change in our lives and society. Intelligent physical robots have gained the attention of practitioners and academics in the healthcare field. Though studies have researched intelligent physical robots in specific healthcare contexts, there is a lack of a full picture of these research streams.

OBJECTIVE

This study aimed to synthesize extant knowledge on intelligent physical robots in the healthcare literature, with an integrative framework towards a holistic understanding of the topic and the identification of promising agendas for future research.

METHODS

We conducted a systematic literature review on intelligent physical robots in the healthcare field, following the guidelines of Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA). The steps were: database search, study selection, screening, data extraction, analysis, and synthesis.

RESULTS

We systematically reviewed a body of 95 research articles on intelligent physical robots in the healthcare context and identified the applied theories, research methods, research contexts, target users and robotic devices in the literature. We then reviewed the antecedents and consequences of intelligent physical robot use in the healthcare context and developed an integrative framework to illustrate the prior research findings on these. Building on our analysis of these results, we propose some future research agendas in the related research area with respect to research concept, research theme, research method, and technology.

CONCLUSIONS

This study contributes to the literature by summarizing the current knowledge in the field of intelligent physical robots in healthcare and by proposing potential future research agendas in the specific area based on the research findings in the literature and the identified knowledge gaps.
Waiting lists for psychotherapy and provider attitudes towards digital and non-digital low-intensity interventions (Preprint)
Authors: Peipert Allison , Krendl Anne C. , Lorenzo-Luaces Lorenzo
Published: May 2022

BACKGROUND

Common mental disorders (CMDs), including depression and anxiety, are leading causes of disability worldwide. Digital mental health interventions (DMHIs), like online self-help, and other low-intensity treatments (LITs) that are not digital, such as bibliotherapy, have potential to reach many individuals by circumventing common barriers present in traditional mental health care but it is unclear how often they are used in clinical practice.

OBJECTIVE

The aims of the present study were to: 1) describe current practices for treatment waiting lists, 2) describe providers’ attitudes towards digital and non-digital LITs for patients on a waiting list, and 3) explore providers’ willingness to use and decisions to learn about digital and non-digital LITs.

METHODS

We surveyed 141 practicing mental health care providers and provided an opportunity to learn about LITs.

RESULTS

Most participants reported keeping a waiting list. Few participants reported currently recommending digital or non-digital LITs, though most were willing to use at least one for patients on their waiting list. Attitudes towards digital and non-digital LITs were neutral to positive. Guided digital and non-digital LITs were generally perceived to be more effective but less accessible, and unguided interventions were perceived to be less effective but more accessible. Most participants selected to access additional information on LITs, with the most popular being online self-help.

CONCLUSIONS

Results suggest providers are currently not recommending LITs for patients on treatment waiting lists but would be willing to recommend them. Future work should explore barriers and facilitators to implementing digital and non-digital LITs for patients on treatment waiting lists.