bluuebunny/crossref_metadata_2025 huggingface dataset:
The Rift Valley fever (RVF) vaccine candidate 40Fp8 shows an extreme attenuation in IFNARKO mice following intranasal inoculation
Authors: Borrego Belén , Alonso Celia , Moreno Sandra , de la Losa Nuria , Sánchez-Cordón Pedro José , Brun Alejandro
Published: August 2024

Rift Valley fever (RVF) is an important zoonotic viral disease affecting several species of domestic and wild ruminants, causing major economic losses and dozens of human deaths in various geographical areas of Africa, where it is endemic. Although it is not present in Europe, there is a risk of its introduction and spread linked to globalisation and climate change. At present, the only measure that could help to prevent the disease is vaccination of flocks in areas at risk of RVF. Available live attenuated vaccines are an effective means of controlling the disease, but their use is often questioned due to residual virulence, particularly in susceptible hosts such as pregnant sheep. On the other hand, no vaccine is currently licensed for use in humans. The development of safe and effective vaccines is therefore a major area of research. In previous studies, we selected under selective mutagenic pressure a highly attenuated RVFV 56/74 virus variant called 40Fp8. This virus showed an extremely attenuated phenotype in both wild-type and immunodeficient A129 (IFNARKO) mice, yet was still able to induce protective immunity after a single inoculation, thus supporting its use as a safe, live attenuated vaccine. To further investigate its safety, in this work we have analysed the attenuation level of 40Fp8 in immunosuppressed mice (A129) when administered by the intranasal route, and compared it with other attenuated RVF viruses that are the basis of vaccines in use or in development. Our results show that 40Fp8 has a much higher attenuated level than these other viruses and confirm its potential as a candidate for safe RVF vaccine development.
Reported healthcare-seeking of loiasis patients and estimation of the associated monetary burden in Gabon: Data from a cross-sectional survey
Authors: Veletzky Luzia , Schlicker Veronika , Hergeth Jennifer , Stelzl Daniel R. , Zoleko Manego Rella , Mombo-Ngoma Ghyslain , Eberhardt Kirsten Alexandra , McCall Matthew B. B. , Adegnika Ayôla A. , Lell Bertrand , Mordmüller Benjamin , Adegnika Scherif , Ramharter Michael , Budke Christine
Published: August 2024

Background

Loiasis is a disease of relevance in endemic populations and there has been advocacy for its inclusion on the World Health Organization’s neglected tropical diseases list. As loiasis-related healthcare-seeking behaviors and related costs are unknown, we aimed to evaluate these aspects in a population residing in an endemic region in Gabon.

Methods

Data were collected during a community-based, cross-sectional study assessing the disease burden due to loiasis. Diagnostics for microfilaremia were performed and a history of eyeworm was obtained. In addition, a standardized questionnaire about type of healthcare resources and frequency of use, as well as respective associated costs was administered to each participant. Loiasis related healthcare-seeking behaviors were evaluated, and the associated monetary burden was estimated as a secondary outcome of the study.

Findings

Individuals diagnosed with loiasis more frequently reported any healthcare-seeking (OR 1.52 (95%CI: 1.21–1.91)), self-medicating (OR 1.62 (1.26–2.08)), inability to work (OR 1.86 (1.47–2.35)), and consulting with traditional healers (logOdds 1.03 (0.52–1.53)), compared to loiasis negative individuals. The most frequently reported treatment for the eyeworm was traditional herbs. The estimated healthcare associated costs, per positive individual, was US-$ 58 (95% CI: 21–101) per year, which would correspond to 3.5% of the reported mean household income. Extrapolation to the rural population of Gabon (n = 204,000), resulted in an annual monetary burden estimate of US-$ 3,206,000 (1,150,000–5,577,000).

Interpretation

Loiasis patients have demonstrated healthcare needs, often consulted traditional healers, and used traditional treatments for disease specific symptoms. Further, loiasis seems to be associated with substantial direct and indirect costs for individuals and thus may cause a relevant economic burden for endemic populations and economies of affected countries.
Adolescent HIV prevent and care framework: A global scoping review protocol- BSGH 006
Authors: Abu-Ba’are Gamji Rabiu , Shamrock Osman Wumpini , Rodriguez Darcey , Agbemedu George Rudolph Kofi , Nelson LaRon E.
Published: August 2024

Among adolescents, HIV/AIDs remains a significant cause of death globally [1–4]. Given the unique stages in human development, adolescents have been shown to fall within a sexually active phase. Combined with other social and structural factors in their immediate environments, HIV prevention and care among adolescents can be filled with challenges for intervention. This paper outlines this protocol to systematically review peer-reviewed literature in prevention and care among adolescents 10–19 years. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews (PRISMA-ScR) will be used to report this scoping review. The review will involve screening and extracting data using covidence as the primary tool. The review will encompass quantitative, qualitative, and mixed methods studies, utilizing a search strategy from electronic databases such as PubMed (NCBI), Web of Science Core Collection (Clarivate), Embase (Elsevier), and Scopus (Elsevier). Additionally, a search will be conducted for grey literature using Global Index Medicus (WHO), MedNar (Deep Web Technologies), and Central Register of Controlled Trials (Cochrane). Duplicate removal and selection of articles that meet the inclusion criteria for the study will be performed using Covidence. Once the screening process is complete, data will be extracted from the full-text screened articles in Covidence. We will pilot the extracted data in Covidence to ensure that all relevant information has been captured, making necessary changes if required. Data extraction will be carried out by at least two authors, with any conflicts resolved by the same authors. If a conflict cannot be resolved between the two, a third author will make a final determination. We aim to analyze data thematically by employing a grounded theory approach to generate codes pertinent to the research question. The team will review and discuss codes to create a cohesive set of codes that will be instrumental in identifying knowledge gaps and constructing themes that summarize the data. The proposed systematic review will be among the pioneering efforts to rigorously assess global data on HIV prevention and care, with a specific focus on adolescents 10–19 years. It will consider the diverse socio-economic factors and experiences shaping these adolescents’ lives in HIV prevention and care. We expect this review to yield critical insights into the present landscape of HIV prevention and care for individuals aged 10–19. These findings will also play a pivotal role in shaping the development of a global framework that researchers and stakeholders can readily adopt and implement across socio-economic contexts. This framework will aim to address the unique needs of all adolescents concerning HIV prevention and care.
Physical activity in adult users of inpatient mental health services: A scoping review
Authors: Tew Garry A. , Peckham Emily , Ker Suzy , Smith Jo , Hodgson Philip , Machaczek Katarzyna K. , Faires Matthew
Published: August 2024

People with severe mental illness engage in considerably less physical activity than those without. They also experience premature mortality of around 10–25 years. A large proportion of these premature deaths are attributed to modifiable behaviours, including physical activity. The inpatient environment provides an opportunity to support people to become more physically active; however, there is limited evidence on which interventions are most successful and what contextual factors affect their delivery. A scoping review was conducted to help understand the extent and type of evidence in this area and identify research gaps. We included studies of physical activity correlates and interventions in adult inpatient mental health services published in peer-reviewed journals. Reviews, meta-analyses, and papers focusing on eating disorder populations were excluded. We searched the MEDLINE, CINAHL, PsycINFO, ASSIA and Web of Science databases for relevant studies published in English. We extracted data on study design, participant characteristics, intervention and control conditions, key findings, and research recommendations. We used a descriptive analytical approach and results are presented in tables and figures. Of 27,286 unique records screened, 210 reports from 182 studies were included. Sixty-one studies reported on correlates of physical activity, and 139 studies reported on physical activity interventions. Most intervention studies used a single-group, pre-post design (40%) and included fewer than 100 participants (86%). Ninety percent of interventions delivered physical activity directly to participants, and 50% included group-based sessions. The duration, type, frequency and intensity of sessions varied. Mental health was the most commonly reported outcome (64%), whereas physical activity was rarely an outcome (13%). Overall, there is a modest but growing body of research on physical activity in adult users of inpatient mental health services. More high-quality trials are needed to advance the field, and future research should target neglected intervention types, outcomes, populations and settings.
An optimized model based on adaptive convolutional neural network and grey wolf algorithm for breast cancer diagnosis
Authors: Alnowaiser Khaled , Saber Abeer , Hassan Esraa , Awad Wael A.
Published: August 2024

Medical image classification (IC) is a method for categorizing images according to the appropriate pathological stage. It is a crucial stage in computer-aided diagnosis (CAD) systems, which were created to help radiologists with reading and analyzing medical images as well as with the early detection of tumors and other disorders. The use of convolutional neural network (CNN) models in the medical industry has recently increased, and they achieve great results at IC, particularly in terms of high performance and robustness. The proposed method uses pre-trained models such as Dense Convolutional Network (DenseNet)-121 and Visual Geometry Group (VGG)-16 as feature extractor networks, bidirectional long short-term memory (BiLSTM) layers for temporal feature extraction, and the Support Vector Machine (SVM) and Random Forest (RF) algorithms to perform classification. For improved performance, the selected pre-trained CNN hyperparameters have been optimized using a modified grey wolf optimization method. The experimental analysis for the presented model on the Mammographic Image Analysis Society (MIAS) dataset shows that the VGG16 model is powerful for BC classification with overall accuracy, sensitivity, specificity, precision, and area under the ROC curve (AUC) of 99.86%, 99.9%, 99.7%, 97.1%, and 1.0, respectively, on the MIAS dataset and 99.4%, 99.03%, 99.2%, 97.4%, and 1.0, respectively, on the INbreast dataset.
Effects of calcium channel blockers in patients with heart failure with preserved ejection fraction: A protocol for systematic review and meta-analysis
Authors: Fukuta Hidekatsu , Goto Toshihiko , Kamiya Takeshi
Published: August 2024

Background

Nearly half of patients with heart failure (HF) have preserved ejection fraction (EF) and the mortality and morbidity of patients with HF with preserved EF (HFpEF) are high. Patients with HFpEF are often elderly and their primary chronic symptom is severe exercise intolerance. Due to the frequent coexistence of hypertension in HFpEF patients, the use of anti-hypertensive medications is common in their treatment. While many cohort studies and several randomized controlled trials (RCTs) have examined the effectiveness of various anti-hypertensive drugs such as beta-blockers and renin-angiotensin system inhibitors in HFpEF, the role of calcium channel blockers (CCBs) remains uncertain. Despite several RCTs and cohort studies exploring the effects of CCBs on prognosis and exercise capacity in HFpEF patients, the findings have been inconsistent, likely due to limited statistical power and/or variations in study design. Therefore, our aim is to conduct a systematic review and meta-analysis of studies on the effects of CCBs in these patients.

Methods

This meta-analysis will include RCTs and cohort studies on the effect of CCBs in HFpEF patients. Information of studies will be collected from PubMed, Web of Science, and Scopus. The primary outcome of interest will be prognosis. The secondary outcome of interest will be exercise capacity.

Discussion

Synthesizing our meta-analytical results with expert consensus could contribute to the formulation of updated clinical guidelines. Our systematic review and meta-analysis will provide directions for future research on the use of CCBs in HFpEF patients.

Systematic review registration

INPLASY202430097.
BnVP1, a novel vacuolar H+ pyrophosphatase gene from Boehmeria nivea confers cadmium tolerance in transgenic Arabidopsis
Authors: Zhu Shoujing , Chen Lei , Zhang Zhonggui , Chen Gang , Hu Nengbing
Published: August 2024

Plants have developed precise defense mechanisms against cadmium (Cd) stress, with vacuolar compartmentalization of Cd2+ being a crucial process in Cd detoxification. The transport of Cd into vacuoles by these cation / H+ antiporters is powered by the pH gradient created by proton pumps. In this study, the full-length cDNA of a vacuolar H+-pyrophosphatase (V-PPase) gene from Boehmeria nivea (ramie), BnVP1, was isolated using the rapid amplification of cDNA ends (RACE) method. The open reading frame (ORF) of BnVP1 is 2292 bp, encoding a 763 amino acid V-PPase protein with 15 predicted transmembrane domains. Sequence alignment and phylogenetic analysis revealed that BnVP1 belongs to the Type I V-PPase family. Quantitative RT-PCR assays demonstrated that BnVP1 expression was significantly higher in ramie roots than in shoots. Cd treatments markedly induced BnVP1 expression in both roots and leaves of ramie seedlings, with a more pronounced effect in roots. Additionally, BnVP1 expression was significantly upregulated by the plant hormone methyl jasmonate (MeJA). Heterologous expression of BnVP1 in transgenic Arabidopsis significantly enhanced V-PPase activity in the roots. The growth performance, root elongation, and total chlorophyll content of transgenic plants with high tonoplast H+-PPase (V-PPase) activity were superior to those of wild-type plants. Overexpression of BnVP1 reduced membrane lipid peroxidation and ion leakage, and significantly increased Cd accumulation in the roots of transgenic Arabidopsis seedlings. This study provides new genetic resources for the phytoremediation of Cd-contaminated farmland.
Optimizing motion detection performance: Harnessing the power of squeeze and excitation modules
Authors: Mpofu Jabulani Brown , Li Chenglong , Gao Xinyan , Su Xinxin
Published: August 2024

This paper introduces an innovative segmentation model that extends the U-Net architecture with a Squeeze and Excitation (SE) mechanism, designed to enhance the detection of moving objects in video streams. By integrating this model into the ViBe motion detection algorithm, we have significantly improved detection accuracy and reduced false positive rates. Our approach leverages adaptive techniques to increase the robustness of the segmentation model in complex scenarios, without requiring extensive manual parameter tuning. Despite the notable improvements, we recognize that further training is necessary to optimize the model for specific applications. The results indicate that our method provides a promising direction for real-time motion detection systems that require high precision and adaptability to varying conditions.
Drug-induced QT interval prolongation in patients with heart failure with preserved ejection fraction
Authors: Huang Chien-Yu , Overholser Brian R. , Sowinski Kevin M. , Jaynes Heather A. , Kovacs Richard J. , Tisdale James E.
Published: August 2024

Heart failure (HF) with reduced ejection fraction (HFrEF) is a risk factor for drug-induced QT interval prolongation. It is unknown if HF with preserved ejection fraction (HFpEF) is also associated with an increased risk. Dofetilide and sotalol are potent QT interval-prolonging agents that are frequently used in patients with HFpEF, in whom atrial fibrillation is a common comorbidity. We tested the hypothesis that the risk of QT interval prolongation associated with dofetilide and sotalol is increased in patients with HFpEF. We conducted a retrospective cohort study conducted using electronic health records from the Indiana Network for Patient Care (January 31, 2010 –May 3, 2021). After removing patients with overlapping diagnoses of HFpEF and HFrEF, no diagnosis code, and absence of QT interval records, we identified patients taking dofetilide or sotalol among three groups: HFrEF (n = 138), HFpEF (n = 109), and no HF (n = 729). QT prolongation was defined as heart rate-corrected QT (QTc) > 500 ms during dofetilide/sotalol therapy. Unadjusted odds ratios (OR) for QT prolongation were determined by univariate analysis. Adjusted ORs were determined by generalized estimating equations (GEE) with logit link to account for an individual cluster with different times of hospitalization and covariates. QTc prolongation associated with dofetilide or sotalol occurred in 53.2%, 71.7% and 30.0% of patients with HFpEF, HFrEF, and patients with no HF, respectively. After adjusting for age, sex, race, serum potassium and magnesium concentrations, kidney function, concomitant drug therapy, and comorbid conditions, the adjusted odds of QTc prolongation were significantly higher in patients with HFpEF [OR = 1.98 (95% CI 1.17–3.33)], and in those with HFrEF [OR = 5.23, (3.15–8.67)], compared to those with no evidence of HF. The odds of QT prolongation among inpatients receiving dofetilide or sotalol were increased in patients with HFpEF and HFrEF compared to those who did not have HF.
Population immunity to varicella in Canada: A Canadian Immunization Research Network (CIRN) study
Authors: Wright James , Crowcroft Natasha , McLachlan Elizabeth , Perez-Iratxeta Carol , Joh Eugene , Osman Selma , Hatchette Todd , Deeks Shelley L. , Wilson Sarah E. , Hughes Stephanie L. , Halperin Scott A. , Buchan Sarah A. , Ward Brian J. , Gubbay Jonathan , Brisson Marc , Serhir Bouchra , Severini Alberto , Bolotin Shelly
Published: August 2024

Introduction

The incidence of varicella in Canada has decreased by almost 99% since vaccination was introduced. However, variation in the timing and eligibility of vaccination programs across the country has resulted in some cohorts being under-vaccinated and therefore potentially susceptible to infection.

Methods

We used nationally representative specimens from the Biobank of Statistics Canada’s Canadian Health Measures Survey (CHMS) as well as residual specimens from Ontario collected between 2009–2014 to estimate population immunity across age-groups and geography, and identify any groups at increased risk of varicella infection.

Results

The weighted proportion of specimens with antibody levels above the threshold of protection was 93.6% (95% CI: 92.4, 95.0). Protection was lowest among those aged 3–5 years (54.3%; 95% CI: 47.3, 61.4), but increased with age. Individuals born outside Canada had more than twice the odds of varicella susceptibility than those born in Canada (aOR: 2.7; 95% CI: 1.4, 5.0; p = 0.004). There were no differences by sex or geography within Canada, and there were no statistically significant differences when Ontario CHMS sera were compared to Ontario residual sera, apart from in participants aged 12–19 year age-group, for whom the CHMS estimate (91.2%; 95% CI: 86.7, 95.7) was significantly higher (p = 0.03) than that from residual specimens (85.9%, 95% CI: 81.1, 90.8).

Discussion

Varicella immunity in Canada is changing. Children appear to have low population immunity, placing them at greater risk of infection and at increased risk of severe disease as they age. Our results underscore the importance of performing periodic serosurveys to monitor further population immunity changes as the proportion of vaccine-eligible birth-cohorts increases, and to continually assess the risk of outbreaks.
N6-methyladenosine RNA methyltransferase CpMTA1 mediates CpAphA mRNA stability through a YTHDF1-dependent m6A modification in the chestnut blight fungus
Authors: Zhao Lijiu , Wei Xiangyu , Chen Fengyue , Yuan Luying , Chen Baoshan , Li Ru
Published: August 2024

In eukaryotic cells, N6-methyladenosine (m6A) is the most prevalent RNA epigenetic modification that plays crucial roles in multiple biological processes. Nevertheless, the functions and regulatory mechanisms of m6A in phytopathogenic fungi are poorly understood. Here, we showed that CpMTA1, an m6A methyltransferase in Cryphonectria parasitica, plays a crucial role in fungal phenotypic traits, virulence, and stress tolerance. Furthermore, the acid phosphatase gene CpAphA was implicated to be a target of CpMTA1 by integrated analysis of m6A-seq and RNA-seq, as in vivo RIP assay data confirmed that CpMTA1 directly interacts with CpAphA mRNA. Deletion of CpMTA1 drastically lowered the m6A level of CpAphA and reduced its mRNA expression. Moreover, we found that an m6A reader protein CpYTHDF1 recognizes CpAphA mRNA and increases its stability. Typically, the levels of CpAphA mRNA and protein exhibited a positive correlation with CpMTA1 and CpYTHDF1. Importantly, site-specific mutagenesis demonstrated that the m6A sites, A1306 and A1341, of CpAphA mRNA are important for fungal phenotypic traits and virulence in C. parasitica. Together, our findings demonstrate the essential role of the m6A methyltransferase CpMTA1 in C. parasitica, thereby advancing our understanding of fungal gene regulation through m6A modification.
The Art of Response: Art-Based Research on Art Psychotherapy, Maria Konti (2023)
Authors: Nash Gary
Published: August 2024

Review of: The Art of Response: Art-Based Research on Art Psychotherapy, Maria Konti (2023)

Athens: ΕΜΣΤ, 132 pp.,

ISBN 978-6-18550-712-1, p/bk, €20.00
Productivity Analysis in the Production Process Using the Six Sigma Method (Case Study at the XSMK Company)
Authors: Worldailmi Elanjati
Published: August 2024

XSMK company is a company engaged in the furniture sector that produces various kinds of shelving products in Indonesia. There are problems that hinder the productivity of the company, namely waste in the production process. Six Sigma is an organized and systematic method for process improvement strategy and new product development that relies on statistical methods and scientific methods to create reductions in product defect rates. With the Six Sigma method, the company implements a vision of quality improvement towards the target of 3.4 failures per million opportunities DPMO (Defects Per Million Opportunities). For this reason, a study was conducted which aimed to determine the value of six sigma, the causes of product rejects, as well as suggestions for improvements to the company. From the results of data processing, the company has an average sigma level of 4,336 with a possible damage of 5,867.5 units for one million productions. There are 4 out of 11 processes that cause rejected products, namely Pond, Bending Plate, Spot, Welding. The main cause of Reject is plate Bending with the percentage of total Reject being 48.077%. From the problems that occur, actions can be taken to minimize Reject products in the production process at the company in the form of making improvements to the Pond Process, Plate Bending Process, Spot Process, Welding Process, Machines, Workers, Raw Materials, and Systems that exist in the company.
Building Material Inventory Planning Using Always Better Control (ABC) and Economic Order Quantity (EOQ)
Authors: Irwan Sukendar
Published: August 2024

Langgeng Jaya is a retail business engaged in the sale of construction materials and building tools. TB. Langgeng Jaya has erratic demand historical data. So the problem arises how much inventory is needed. Building materials in TB. Langgeng Jaya is obtained from quite a lot of distributors or suppliers with different lead times for each company. Inefficient management results in problems in product inventory such as out of stock and excess stock of building materials being sold. To overcome this problem, the method used in this research is Always Better Control (ABC) and Economic Order Quantity (EOQ) analysis. The ABC method is used to classify a large number of product types into three groups, namely group A, group B, and group C. In this approach it results that those included in group A are 30 types of products with a monetary value percentage of 77.46%. group B there are 31 types of products with a monetary value of 12.57%, while for group C there are 89 types of products with a monetary value of 9.97%. Group A has a higher cumulative price percentage value than groups B and C which will later become the focus for further processing using the EOQ method. By using the EOQ (Economic Order Quantity) multi-item multi-supplier and single item single-supplier policies, this can reduce the costs incurred from ordering goods from suppliers. The results of the EOQ (Economic Order Quantity) method approach, namely the difference in costs incurred by the average company, are Rp. 1,192,537.
Productivity Analysis Using the Multi Factor Productivity Measurement Model (MFPMM) as an Effort to Increase Competitiveness (Case Study: WL Alumunium Yogyakarta)
Authors: Dewi Grita Supriyanto , Nadiyah Khairun
Published: August 2024

It is known that the national economy is dominated by Cooperatives and Small & Medium Enterprises (SMEs), this proves that Cooperatives and SMEs have competitiveness and potential that must be maintained. WL Aluminum is an SME located in the Yogyakarta area which is engaged in the metal casting industry with products that include frying pans, citel, pans and other kitchen utensils. In order for a business to survive and continue to grow, it must be able to compete by preparing various strategies so that the products it produces will always exist in the market. One form of strategy that can be used is by measuring the company's productivity. This is used to determine the extent to which the effectiveness of the product produced and the efficiency of the use of available resources. Several variables that affect productivity include raw materials, energy and labor. The purpose of this research is to find out what the productivity index (PI) is for WL Aluminum using the MFPMM, and to find out whether there is an influence between the profitability received by WL Aluminum and productivity and price changes using the Multiple Linear Regression method. The results of productivity calculations using the MFPMM show that PI was in a row October-November 2015, November-December 2015; December-January 2016; January-February 2016; February-March 2016; March-April 2016; April-May 2016 of 1.0064; 1.2370; 0.8545; 0.9016; 0.9607; 1,1,068; 0.7348. The results of the mathematical equation using Multiple Linear regression are profitability (Y): -0.952+ 1.001 productivity (x1) + 0.951 price recovery (x2). Testing with the F test shows that the calculated F value is 1401891.948 with a significance value of 0.000 <0.05. This proves that profitability is influenced by productivity and price changes.
Tabu Search Algorithm for Optimization of Blood Distribution Routes
Authors: Mulyadi Agus , Meirizha St. Nova , Andriyas Ari , Pratama Irsan
Published: August 2024

PMI Blood Transfusion Unit (UTD PMI) is an agency that provides or a health service agency that organizes blood donation and blood supply. The observations and interviews showed that some existing cases were not carried out immediately and accurately, and there was no distance to align the duration with blood cells. The formation of blood distribution routes only stems from the highest number of requests and the delay in the distribution in several hospitals. Therefore, it is necessary to determine vehicle routes to meet demand due to the limited number of vehicles. The distribution time limit is another obstacle in the distribution process due to delays in delivering blood products from UTD to hospitals or hospital blood banks. In this study, the CCVRPTW solution was determined using a metaheuristic algorithm, namely the Tabu Search algorithm, to minimize blood distribution routes and distances at UTD PMI Pekanbaru. The solution for blood distribution is solved using a programming language through MATLAB software based on the Tabu Search algorithm. Based on the study results, the route 0-1-14-8-18-6-2-17-11-10-4-3-15-9-5-7-16-19-12-13-0 with a distance of 55, 9 KM in 67.1 Minutes. The initial distribution route is 0-1-2-6-5-4-3-7-17-8-13-11-12-14-16-15-18-9-10-19-0 with a distance of 130.7 KM in 156.8 minutes. UTD PMI uses one coolbox with 100 bags of blood capacity, but there is a delay because it only uses one vehicle. The optimized route is divided into two routes: car 1 has a route of 0-1-14-8-18-6-0 with a total distance of 9.2 KM, and car 2 has a route of 0-2-17-11-10-4 -3-15-9-5-7-16-19-12-13-0 with a total distance of 50.6 KM
Child Friendly Markets As A Means Of Public Learning Space For Children
Authors: Awaliyah Dien F , Pangestuti Dinik Fitri Rahajeng , Pandu Tauladan Ihsan , Nurhayati Anifa , Siami Wahyu Lisma
Published: August 2024

The child-friendly market is one of the programs that has begun to be developed in several markets in Indonesia. This program was designed to meet the needs of a safe, comfortable, and accessible environment for families, where children can play, learn, and interact with others while their caregivers carry out buying and selling activities. Child-friendly market is one of some agenda that support Sleman regency to withstand as a Child Friendly City and as a market that located in Sleman regency, Kowen market have the amenability to construct its environment as a child friendly market. Therefore, the aim of this study is to provide material for consideration for policy makers, in this case the management of Kalurahan Sidokarto in the discourse on establishing a child-friendly market at Pasar Kowen. This study is conducted with qualitative method that will be developed in an analytical descriptive manner. Researchers collected data through field research and literature research by applying a sociological approach to produce accurate data.
Forecasting Demand for Electric Batik Stoves Using Moving Average Method in CV. A B C
Authors: Susilo Gunawan Budi
Published: August 2024

Today's economic problems cause companies to be able to manage finances. For companies engaged in production, it is essential to manage finances so that the company does not experience losses. To overcome this, companies need to make optimal production and demand planning. Demand planning, in general, is better known as forecasting. The single-moving average method uses actual demand data to generate forecast values for future demand. This method will be effectively applied if the product's market demand remains stable. This method has two unique properties: making a forecast requires historical data within a certain period, and the longer the moving average, the smoother the moving average will be. The results showed three samples of stoves, namely, type A-AS001 with a MAD value of 118.16, an MSE value of 44015.27, and a MAPE value of 3.93. The type A-AS002 stove shows a MAD value of 7.81, an MSE value of 92.23, and a MAPE value of 0.27. The type A-SD001 stove has a MAD value of 16.16, an MSE value of 550.75, and a MAPE value of 3.72.
Seller Perception Analysis on Purchase Decision Using Analytical Hierarchy Process Method
Authors: Dwijayanti Khusna
Published: August 2024

Purchasing decisions can be used as a competitive advantage for companies or retailer. Purchasing decisions are important aspects of consumer behavior to determine or make a decision whether to buy a product or not. Price, product quality, service quality, and social media promotion can be good strategies to win over existing competitors. There are many studies on consumer perception, and a few studies on seller perception. Therefore, this study aims to analyze the effect of price, product quality, service quality, and social media promotion on purchasing decisions at ABC Store by measuring the perceptions of the sellers. The questionnaires in this study are given to sellers and marketing managers who are experienced in selling the product. The analysis conducted using Analytical Hierarchy Process (AHP). The results of this study indicate that from the perception of the seller, the order of importance that influences the purchase decision for gadget at ABC Store is social media promotion 30%, price 28%, product quality 26%, and lastly service quality 15%.
Layout Design and Product Bundling Strategy Using Overall Variability of Association Rules (OCVR) Method
Authors: Pramudyo Cahyono Sigit
Published: August 2024

Alfazzamart is a minimarket that sells various daily needs. For several months, the number of transactions per month at Alfazzamart fluctuated. Alfazzamart owners want to achieve sales targets so that profits increase. This is a challenge for employees to determine the right product bundling strategy and product layout according to buyer behavior. Therefore, this research was conducted to provide product bundling strategies and layout suggestions based on buyer behavior. This study uses the OCVR method to determine consistent purchasing patterns in each period. Based on this method, the results of the OCVR method are used as a reference in product bundling and product layout. Data processing was carried out following CRISP-DM. Based on the findings of this study, 17 bundling packages were obtained that could be implemented. Bundling package offers can be made by placing the product on the promo shelf or by the cashier offering product bundling recommendations directly. In addition, regarding the proposed change in product layout, it can be done by bringing noodle products closer to snack and soft drink products, swapping the location of bread products with syrup, bringing wafer products closer to candy products, and bringing toy products closer to ice cream so that empty shelves can be filled with accessories.
Measurement of Machine Effectiveness Using the Overall Equipment Effectiveness (OEE) Value Approach on the BX-75 Machine (A Case Study)
Authors: Indro Prakoso  , Andiya Nur Wibowo Denny
Published: August 2024

PT XYZ is a company engaged in the pipe industry with various types of HDPE pipe products according to consumer needs. PT XYZ has problems with the BX-75 engine because it has a high breakdown value and is obtained from historical production data. The high breakdown caused the production process of the BX-75 engine to be hampered and the daily production target was reduced. To determine the effectiveness of the BX-75 engine, measurements using the Overall Equipment Effectiveness (OEE) method are needed. The research was conducted using the OEE method to identify whether it is in accordance with world class standards, if the OEE value is still low, a Six Big Losses analysis will be carried out from the pareto chart which will determine what losses affect the low OEE value and analyze the details of the causes of each fishbone diagram. The average OEE value on BX-75 machines in November-December 2022 was 78.86%. The result is still below 85% so six big losses analysis is still needed. There are two types of losses that dominate, namely downtime losses and setup & adjustment losses. Downtime losses have an average loss of 13.50% and setup losses have an average of 9.53%.
Raw Material Inventory Control on Probabilistic Demand and Lead Time Using Continuous Review System
Authors: Parkhan Ali , Widodo Imam Djati , Fausa Erlangga , Qurtubi
Published: August 2024

Excess inventory will lead to high inventory costs caused, among others, by damage and possible loss of stored goods embedded capital; on the other hand, a list is needed to ensure fulfillment of needs and reduce demand fluctuations and supply fluctuations to avoid loss of profit opportunities. This study aims to manage the uncertainty of usage and lead time in a wooden toy company, which can result in an excess or shortage of raw materials in the inventory system. It is necessary to control inventory to ensure optimal inventory; that is, needs can be met with minimal inventory costs and adequate service levels. The result, optimal condition is achieved if the company orders wood when the amount of inventory is (r) = 24,422 units with an order quantity of (Q) = 10,010 units each time you place an order, with a total inventory cost in 2023 of IDR 362,156,168, this policy will result in a service level (η) = 95.14%.
Design Maintenance System on Mixer Machine to Prevent the Breakdown Using Reliability Centered Maintenance
Authors: Kusuma Budhi Santri , Syahputra Mhd. Ardian , Yanti Roaida , Muthawali Dede Ibrahim
Published: August 2024

Equipment, machinery, and labor are fundamental assets of an organization. Therefore, companies must have an appropriate and scheduled maintenance system. However, many manufacturing companies neglect maintenance, leading to frequent machine breakdowns that can result in machine downtime and financial losses. This research aims to determine the machine maintenance interval and the types of actions to be taken. The method employed is Reliability Centered Maintenance with the Failure Mode and Effect Analysis approach to identify failure patterns in a system and formulate the best strategies for designing a maintenance system. The results indicate that the CS-20 Type B mixer is the most critical machine, which can significantly reduce the company's production output due to machine downtime during the repair process. Based on the Reliability Maintenance method, the maintenance interval for components with potential failures is 273.17 hours for the bearing component, experiencing breakdowns three times with the highest damage occurrence within one year.
Perceived Styles of Parents on Alexithymia: The Mediating Role of Emotional Schemas in Married People with Migraine
Authors: Mansoury Jam Maryam , Dokanehei Fard Farideh
Published: August 2024

The purpose of this research is to investigate the perceived styles of parents on alexithymia with the mediating role of emotional schemas in married people with migraine. In terms of practical purpose, the current research is a descriptive-correlation with structural equations. The statistical population includes all married men and women in Tehran who referred for migraine treatment to hospitals in 2022, the number of whom is 440. Therefore, with the help of Cochran's formula, 208 people were selected and the questionnaire was distributed among them in a convenient and simple random method. Cronbach's alpha coefficient was used to determine the validity of the questionnaire using the method of content validity and reliability of the questionnaire. Finally, the coefficients showed that the data collection tool has high reliability. In order to check the validity of the questionnaire, confirmatory factor analysis and in order to check the research hypotheses from structural equation modeling, the structural equation modeling (SEM) method was used with the help of SmartPLS 3 software. Conclusion: In the end, all research hypotheses have been confirmed and suggestions and solutions have been presented to improve the physical and mental states of families and the perceived styles of parents.
Optimization Supporting Facilities for Perormance Security Officers at Banyuwangi Airport
Authors: Islam Fajar , Rusdyansyah Arief
Published: August 2024

The purpose of this research is to optimize work facilities and security facilities for security officers at Banyuwangi Airport, with the hope of increasing the performance and efficiency of security officers in carrying out their duties. The research method used is a quantitative research method using questionnaires distributed to 50 security officers at Banyuwangi Airport to obtain data which is then analyzed. The results of the F test show that simultaneously or together the Work Facilities and Security Facilities have a significant effect on the Performance of Security Officers. Furthermore, the results of the t-test show that Work Facilities and Security Facilities each have a significant effect on Security Officer Performance. Therefore, it is important for airport management to pay attention to and improve Work Facilities and Security Facilities in order to improve the Performance of Security Officers at Banyuwangi Airport. The results of this study, it can be concluded that Work Facilities (X1) and Security Facilities (X2) have a significant effect on Security Officer Performance (Y) at Banyuwangi Airport. Work Facilities and Security Facilities factors affect 79% of Security Officer Performance, while 21% are influenced by other factors not examined in this study.
Pengaruh literasi keuangan dan sikap keuangan terhadap pengelolaan keuangan pada usaha Depot air minum di Ternate
Authors: M. Sumadayo Karlina
Published: August 2024

Tujuan Penelitian ini adalah: 1. Untuk mengetahui dan menganalisis pengaruh literasi keuanganterhadap pengelolaan keuangan pada usaha depot air minum di ternate. 2. Untuk mengetahui danmenganalisis pengaruh sikap keuangan terhadap pengelolaan keuangan pada usaha depot airminum di ternate. Jumlah sampel dalam penelitian ini adalah 73 responden depot air minum diTernate. Alat uji yang digunakan adalah analisis regresi linier berganda dengan menggunakanStatistical Package For Sosial Scientist (SPSS) 29 sebagai alat uji statistic. Hasil penelitianmenunjukan:(1).Literasi keuangan berpengaruh dan signifikan terhadap pengelolaan keuanganpada usaha depot air minum di Ternate. (2)Sikap keuangan berpengaruh dan signifikan terhadappengelolaan keuangan pada usaha depot air minum di Teranet.
A detailed survey on fungal distribution and characterization under Bankura District, West Bengal, India
Authors: Ganguly Arindam , Mukhopadhyay Pabitra , Ghanta Rebeca , Mallick Shyamal Kanti , Mandal Asish , Mukherjee Samir Kumar
Published: August 2024

Fungi are the eukaryotic organism which shows heterotrophic nutrition. Wild edible mushrooms, which are abundant in proteins, are prepared as delicious cuisine. This attribute makes it a lucrative venture for numerous indigenous communities, particularly during the rainy season. Many fungi have medicinal properties. A total of 14,000 species are verified, among them 7000 are known for edible nature and only 10% thought to be poisonous. Now many researchers are showing their interest on fungi to gain knowledge about their diversity, morphological, anatomical features and bio-chemical nature. In the present study 3 different places namely Bishnupur, Ramsagar and Onda of Bankura District have been surveyed. A total of 24 fungal species have been collected and identified among which total number of edible fungi are 8, total numbers of poisonous fungi are 4 and total numbers of inedible fungi are 12. It has been known that 5 fungi are medicinally used by the local tribal people. The anatomical study shows that the gills are parallelly arranged, basidia mostly club shaped, spores are bilayered and brown in colour. The majority of collected fungi are under different families of division Basidiomycota and only one species that is Daldinia concentrica falls under the family Xylariaceae belonging to the division Ascomycota. The present study also shows that Agaricaceae family contains highest number of genus of total fungal population and Basidiomycota members (with 95.8% occurrence) so dominant in the region in comparison to those of Ascomycota  (with 4.2% occurrence) members.
Carbon Taxes and CO2 Emissions: A Replication of Andersson (American Economic Journal: Economic Policy, 2019)
Authors: Yu Yanxia
Published: August 2024

Do carbon taxes reduce CO2 emissions in the countries that adopt it? Andersson (2019. Carbon taxes and CO2 emissions: Sweden as a case study. American Economic Journal: Economic Policy, 11(4), 1–30) provides a clear, affirmative answer. His article has been widely cited as evidence that carbon taxes “work.” To check whether the estimates from Andersson (2019) are reliable, I replicate his article using its publicly available data and codes. I modify his synthetic control method (SCM) by using a more restricted set of control units (excluding one potentially treated unit). I also use a more efficient methodology, the Prais-Winsten estimator, to estimate price effects on gasoline consumption. In addition, I compute prediction intervals (PIs) and add these to the SCM estimates, using the newly developed scpi R package. My best estimate is that carbon taxes reduced per-capita CO2 emissions in Sweden’s transport sector by 7.7%, confirming Andersson’s main finding. I then extend Andersson’s approach to the Norwegian transport sector, estimating a smaller reduction of 2.4%. However, this effect falls within the PIs of the estimates assuming no carbon taxes. When I extend the analysis to the national level in Sweden, I estimate wide PIs and obtain inconclusive results.
Wideband circularly polarized reconfigurable metasurface antenna for 5G applications
Authors: Ellusamy Sivakumar , Balasubramanian Ramachandran
Published: August 2024

A framework of a metasurface (MTS) – based wideband circularly polarized (CP) reconfigurable antenna for fifth generation (5G) wireless systems operating in the sub-6 GHz mid-frequency range is presented in this article. The proposed structure contains a simple patch antenna, which serves as the primary source, a shorting pin, two ring slots, and a metasurface superstrate. The shorting pin and two ring slots produce perturbation resulting in circular polarization with a narrow axial ratio (AR) bandwidth. A metasurface (MTS) superstrate composed of 4 × 4 rectangular patches stacked over the primary source antenna generates additional resonances that significantly improve the −10 dB impedance and 3 dB axial ratio (AR) bandwidth. Two PIN diodes are employed to alter the circular polarization between left-hand circular polarization (LHCP) and right-hand circular polarization (RHCP). The prototype is made using an FR-4 epoxy substrate and has an overall size of 50 mm × 35 mm × 4.2 mm. The antenna has a −10 dB bandwidth of 44 % (4.0–6.2) and a 3 dB axial ratio bandwidth of 28 % (4.2–5.6). It also has a 3 dB beam width of 74° and 85° in the E and H planes, a gain of 7.1 dBi, cross-polar isolation of more than 15 dB, and a unidirectional radiation pattern. The simulated and measured results confirm that the implemented antenna is promising for sub-6 GHz 5G communication systems, particularly cognitive radio, wireless body area networks (WBAN), and satellite communication systems.