bluuebunny/crossref_metadata_2025 huggingface dataset:
EFEITO DO ÓLEO DE COPAÍBA (COPAIFERA SP) COMO INSETICIDA NATURAL SOBRE O CARUNCHO COLLOSOBRUSCHUS MACULATOS EM FEIJÃO-DE-CORDA ARMAZENADO.
Authors: Silva Jonatas Tavares da , Silva Renato Augusto Da , Silva Vania Mirelly Bento Da , Lima Maria Danielle Gomes De , Santos José Romário Nunes Dos
Published: October 2021

Introdução: O inseto Callosobruchus maculatus, popularmente conhecido como caruncho, é uma das principais pragas do feijão-de-corda (Vigna ungguiculata (L) Walp) e tem causado perdas consideráveis na produção do grão. Diante disto, diversos produtos naturais são considerados promissores para o manejo integrado de C. maculatus nas unidades de armazenamento substituindo os inseticidas sintéticos. Objetivo: Avaliar o efeito do óleo de Copaíba (Copaifera sp) como inseticida natural contra o caruncho C. maculatus em feijão-de-corda armazenado. Material e Métodos: Os insetos foram criados por várias gerações em grãos de feijão-de-corda, acondicionados em recipientes plásticos de 2 litros, fechado de forma a permitir apenas a troca de gases. As amostras de feijões-de-corda e óleo de copaíba, foram adquiridos aleatoriamente na feira livre de Serra Talhada – PE. Os feijões foram previamente mantidos em freezer a uma temperatura de -10ºC por 7 dias, para eliminação de eventuais infestações de insetos e outras pragas provenientes do campo. Para avaliar a atividade inseticida, as doses utilizadas no experimento foram 0,0 (testemunha), de 9,6 mg; 18,2 mg; 28,8 mg; 38;4 mg e 48, 0mg do óleo/ 20g, com quatro repetições casualizadas. Cada repetição contava com 20 feijões acondicionados em recipiente de 100 mL, infestado com 10 insetos de C. maculatus com 0-72h de idade. O óleo de copaíba foi adicionado gota a gota e submetido a agitação manual por 1min. Após 48h, os insetos eram retirados e a mortalidade percentual foi avaliada. Resultados: A Concentração Letal Média (CL50) foi estimada em 17,25 mg do óleo/20g (863 mg/KG) de feijão por meio da curva de tendência utilizando o programa software Excel 2010, Office, da Microsoft. Conclusão: Percebe-se que óleo de copaíba se apresenta como uma alternativa simples e eficiente no controle da praga do feijão-de-corda, podendo substituir os inseticidas químicos sintéticos que são danosos a saúde.
Un centre-ville rose
Authors: Botes Jonathan
Published: October 2021

Johannesbourg, plus grande ville d’Afrique du Sud et cœur économique du pays, possède une riche histoire de culture queer. L’article se concentre sur le quartier de Hillbrow, dans les années 1970 et 1980, à une époque où il est considéré comme le centre gay de Johannesbourg. Il a pour objectif de montrer comment les homosexuels ont façonné, dans ce quartier du centre-ville, une culture urbaine propre, avec la création de clubs et de bars gays ou gay-friendly, avec la multiplication des fêtes privées et la constitution d’espaces publics de « drague » (cruising). Ces processus sont examinés dans le contexte de l’Immorality Amendment Act de 1969 qui criminalise les homosexuels. L’article analyse également la dynamique raciale entre homosexuels noirs et blancs, et la façon dont elle a compliqué la production d’espaces gays et queer dans la ville. Basée sur des archives et des entretiens oraux, cette recherche met en lumière l’importance de Hillbrow en tant qu’« espace sûr » (safe space) pour les personnes queer durant les années d’apartheid.
Melody As An Educational Instrument To Create A Better Environment In Elt Classroom
Authors: Kavitha Dr A.
Published: October 2021

Young children are learning a second language benefit extensively from songs. The usage of songs in English Language Teaching schools throughout the world is a witness to this. The concept of this study is to scrutinize why pieces may be helpful to teaching aids. It will examine how songs may be used to teach vocabulary and sentence structures and how they can assist learners in improving their listening skills and pronunciation. Integrating English songs into ELT is one pedagogical option. Song, which combines music and lyrics, has many inherent qualities, including a kaleidoscope of culture, expressiveness, reliability, and therapeutic effects, all of which make it an excellent resource for language instruction. This study presents both theoretical and practical justifications for utilizing English songs in ELT.
Affect on Alcheima Disease during Covid-19
Authors:   Laureate certified Student Researcher | Davidson Young Scholar., Gupta Amisha
Published: October 2021

The pandemic COVID-19 is generating worldwide disruption, straining health systems, causing morbidity and death, and placing people with ADRD in danger. In this article, we look at the present and anticipated implication son people with ADRD as a result of the epidemic. We examine and offer reducing measures and death in peopleCOVID-19’s effect on ADRD diagnosis and medical care in people with ADRD; and the COVID-19 repercussions of societal reactions in various ADRD care settings. COVID-19’s influence on physicians and caregivers of people with ADRD; stigma, mental health, and trauma during COVID19; and the prospective COVID-19 impact research on ADRD. Despite much uncertainty, we may be able to avoid or lessen the suffering caused by the epidemic of COVID-19implications for persons with ADRD and about their careers. Anticipated the potential patterns of COVID-19 effects in the world dependent on data gathered from Kaggle and used the Optum Labs Data Warehouse (OLDW),
Automatic Podcast Generation
Authors:   Post Graduate Department of Computer Science, University of Kashmir, Hazratbal., Zahoor Saniya , A.Sofi Shabir ,   Department of Information Technology, National Institute of Technology Srinagar.
Published: October 2021

A massive leap forward in the field of Human Computer Interaction in living memory has been achieved by the Google Duo system to sustain a natural sounding and coherent phone call with a human being without them being able to tell the difference. The computer system capitalized on recent developments in the field of Synthetic voice generation along with real time processing and response generation. The aim of this work is to replicate the success of that presentation as well as to build upon that body of work and generate useful content summaries which can be converted into high quality podcasts. In particular, our approach first comprises of extracting text data from web pages using various Natural Language Processing (NLP) tools as well as deep neural networks. After that it summarises text into byte sized chunks using extractive summarisation. Then, in the end it generates clear, high quality audio podcasts from the produced summaries using recently developed text to speech engines.
IMPACT OF THE USE OF THE SPEECH VALVE ON THE SWALLOWING AND DECANULATION PROCESS
Authors: Regina Nantes de Oliveira Karla , Galdino Franco Patrícia , Cristina Ribeiro Akamine Suellen
Published: October 2021

The speech valve can be safe and effective for tracheostomized, conscious patients with tolerance to deflated cuff. It can be coupled between 48 and 72 hours after tracheostomy, depending on the airway permeability. Objective: The objective of this study was to identify the impact of the use of the speech valve on adult patients hospitalized in the city of Campo Grande, in the state of Mato Grosso do Sul, aiming at swallowing, reintroduction of diet orally in a safe way and decannulation. Method: The longitudinal method with indirect and direct evaluation with PAP, PITA, PARD, BLUE DAY TEST, DECANULATION PROTOCOL AND SCALE was used in adult and hospitalized patients. Results: Regarding the criterion of time for decannulation, after the beginning of the training with the speech valve, we consider the following findings. All patients decannulated within a maximum of 15 days after the use of the speech valve. All started oral feeding in a maximum of 7 days after using the speech valve. And SNE was removed in all patients within 15 days after using the speech valve. There is evidence that the use of the speech valve has positive impacts on the swallowing process, reintroduction of the diet orally in a safe way and on the decannulation process. Conclusion: It was concluded that the use of the speech valve brought benefits to patients, in addition to facilitating the phonation process and the adjustment of the respiratory pattern closer to the physiological one before decannulation has an importance in swallowing and a decrease in the time of swallowing. Decannulation.
HEALTH INFORMATION SYSTEMS SUPPORTED BY MOBILE TECHNOLOGIES:
Authors: Cristina Ribeiro Akamine Suellen
Published: October 2021

Information systems have been standing out and constantly evolving due to changes and the economic impact they produce on organizations and society, and also due to the evolution of information technology itself. These systems are made up of a structure capable of guaranteeing the collection and transformation of data into information, and the involvement of professionals in processes of selection, collection, classification, storage, analysis, dissemination and data retrieval is essential. Mobile technologies offer support so that information systems can be implemented and used more efficiently and quickly, but there are many obstacles, such as the unavailability of technological resources by a large part of the population, difficulties in accessing and connecting, among others. The methodology used to carry out this study was the bibliographical research through literature analysis of scientific articles and other texts. It was concluded that health information systems and mobile technologies tend to conquer more space each day, as they provide more agility and quality in health services, but it is still necessary to improve the population's access to these technological resources.
IMPACT OF THE LABIOPALATINAL FISSURE ON THE QUALITY OF LIFE OF CHILDREN AND ADOLESCENTS IN PERNAMBUCO - BRAZIL
Authors: Gomes Moreira Andreia , Butini Oliveira Luciana
Published: October 2021

Cleft lip and palate are the most frequent anomalies of the face, which can compromise normal functions in addition to interfering with the patient's quality of life. Oral health problems can impact daily life, being more striking for these patients due to their functional and aesthetic changes. The aim of the study was to evaluate the oral health-related quality of life of patients with cleft lip and/or palate at the Center for Attention to Face Defects (CADEFI/IMIP-PE). The sample consisted of 348 patients, 174 aged 8 to 12 years and 174 aged 13 to 18 years. The collection instrument used to measure quality of life was PedsQL 4.0. Data analysis was performed using the STATA 9.0 software, descriptive, observing the absolute and relative frequencies in relation to the demographic and clinical characteristics of the sample and measures of central tendency for the PedsQL 4.0 score and domains. Poisson regression with robust variance was performed to associate the total scores and individual domains of the PedsQL 4.0 with the types of cravings, their prevalence and demographic conditions. Subsequently, the selected variables were tested in the adjusted multivariate model, which could only be maintained if the variables presented p≤ 0.05. Robust rate ratios (RTR) and 95% confidence intervals (95% CI) were calculated. Practically all respondents (99.9%) reported some impact in at least one of the instrument's domains. Children aged 13 to 18 years had a positive impact, better quality of life, compared to those aged 8 to 12 years. Multidisciplinary treatment protocols for the rehabilitation of patients with cleft lip and palate seek to restore function and aesthetics, helping to overcome stigma and integrating into social life, which can justify the favorable results of the assessment of the quality of life of these patients
CRANIAL CRUCIATE LIGAMENT RUPTURE IN THE DOG AND ITS RESOLUTION USING THE SURGICAL TECHNIQUE TPLO -
Authors: Alcantara Garcia Giovana , Gomes Vespoli Lucas , Plácido Guimarães Juliana , De Lara Shecaira Carolina
Published: October 2021

It is known that the cranial cruciate legament is one of the main stabilizers of the knee, and problems in it can bring complications to the animal, including the rupture of the cranial cruciate ligament, which is classified as one of the biggest diseases in the pelvic limbs in dogs. Its diagnosis is made through a thorough consultation and, during the physical exam, the drawer and tibial compression tests. However, as a confirmatory diagnosis, complementary imaging exams are used for a better visualization of suspicious problems. Conservative and surgical treatments are included in its treatment, where the surgical ones include extracapsular, intracapsular, and corrective osteotomies, the latter being the most modern and safest in terms of possible relapse and future joint degeneration, because they are procedures that modify the bone anatomy, restoring stability and returning function to the limb; however, the choice of treatment is always made individually for each patient. Thus, the present study aims to report the case of a patient with rupture of the cranial cruciate ligament and the TPLO surgical technique as a solution, in order to contribute to advances in the field of orthopedics. The information was obtained through follow-up and review of the patient's medical record, photographic record of the exams for which the patient was submitted, and literature review in articles on the Scielo and Google Academic platforms.
The development of a teaching tool using Sketchup to enhance surveying competence at the Durban University of Technology
Authors:   , Stuart Darryl George
Published: October 2021

Surveying concepts are difficult to understand, especially when students are exposed to surveying for the first time. Surveying is best understood when linked to field applications; however, students are only exposed to surveying and related field operation procedures during practicals. Two-dimensional (2D) explanations of surveying equipment used is shown during class lectures, which makes understanding of field procedures difficult to teach and learn during normal class lectures. A new approach to lecture delivery is required to make lectures more interesting and visually stimulating via three-dimensional (3D) animated models of levelling equipment and simulation of field observations and data collection. Additionally the learning of basic surveying concepts cannot be limited to field practicals, but in conjunction with learning that takes place in the classroom. Students' ability to properly learn the correct use of surveying equipment during time-tabled practicals is limited. The students do not have sufficient time in their normal scheduled practicals to learn to use surveying equipment to the required proficiency level. The main objective of this research was to deal with these inadequacies by exposing students to (3D) animated models of surveying equipment during lectures and the corresponding field applications created within SketchUp software. Students were exposed to these animated 3D models during lectures, so that their actual field operation and application could be simulated. Quantitative analysis of the student achievement data revealed that there was a significant difference between the test scores of the control and experimental groups. Additional analysis of the developed Likert-type scale questionnaire revealed that students' had a positive attitude towards the teaching tool.
ОПЫТ ВЫРАЩИВАНИЯ ТИЛЯПИИ (OREOCHROMIS NILOTICUS) В ПРУДАХ НА ГЕОТЕРМАЛЬНОЙ ВОДЕ
Authors: Бадрызлова Нина
Published: October 2021

В статье представлены биотехнические приемы выращивания товарной продукции тиляпии в поликультуре с клариевым сомом в прудах на геотермальном воде. Отражены данные по выращиванию тиляпии при высоких плотностях посадки. Приведены результаты мониторинга основных показателей среды в прудах: температурного и кислородного режимов, водородного показателя. Представлены данные динамики абиотических факторов среды и их влияние на темп роста тиляпии и клариевого сома. Представлен анализ по основным рыбоводно-биологическим показателям  тиляпии, клариевого сома; определены факторы, влияющие на темп их роста и выживаемость. Приведены данные статистических исследований продукционных возможностей тиляпии и клариевого сома. Показана принципиальная возможность выращивания теплолюбивых объектов аквакультуры на геотермальной воде в условиях рыбоводных хозяйств Казахстана, выраженная в хорошей выживаемости и высокой рыбопродуктивности.
ОЦЕНКА ПРОДУКТИВНОСТИ И ПИТАТЕЛЬНОСТИ ПОЛИКОМПОНЕНТНЫХ СМЕСЕЙ И ОДНОВИДОВЫХ ПОСЕВОВ КОРМОВЫХ КУЛЬТУР В УСЛОВИЯХ СЕВЕРНОГО КАЗАХСТАНА
Authors: Baitelenova Aliya
Published: October 2021

В данной статье представлены результаты первого года исследований, изучающие продуктивность и питательность кормовых трав и травосмесей в системе конвейера в условиях сухостепной зоны Северного Казахстана. Исследования проводились в 2020 году на полях ТОО "Племенное хозяйство Зеренда", почва которой относится к темно-каштановым, тяжелая по механическому составу. Метеорологические условия в период проведения экспериментов не соответствовали биологическим потребностям кормовых трав, в виду высокой засушливости и повышенной температуры воздуха в летние месяцы. Однако, наличие почвенной влаги в июле месяце положительно повлияло на развитие культур, и способствовало достижению поставленных задач. Цель исследований заключается в проведении сравнительной оценки продуктивности и питательности травосмесей с читыми посевами кормовых культур, обеспечивающие стабильное повышение урожайности и качества кормов в условиях сухостепной зоны, для круглогодичного обеспечения полноценными кормами МРС. Эксперимент включал в себя многолетние и однолетние кормовые культуры, и их травосмеси. Оценка посевов проводилась по фенологическим наблюдениям, химическому составу, динамике роста растений, урожайности, продуктивности и питательности различных видов кормов. Минимальный период вегетации отмечен у двулетних кормовых трав – 49 дней, максимально продолжительный период вегетации - у пайзы, 116 дней. Максимальная высота среди однолетних растений отмечена у суданской травы, составив перед уборкой 160,2 см, с отставанием на 47 и 64,3 см, следующими по высоте отмечены просо кормовое и африканское просо соответственно. По продуктивности и питательности сена можно отметить среди однолетних трав посевы тритикале и африканского проса – 8,74 и 8,59 МДж/кг, среди двулетних донник волжский – 8,17 МДж/кг, и травосмеси – горох+овес и горох+суданская трава, 8,14 и 8,32 МДж/кг соответственно. В виду практического интереса сельхозтоваропроизводителей к разработке высокопродуктивного сырьевого конвейера для круглогодичного обеспечения полноценными кормами животных, данные исследования являются актуальными, и требуют продолжения, для точности эксперимента.
ОТРАБОТКА ТЕХНОЛОГИИ ВОЗДЕЛЫВАНИЯ КУКУРУЗЫ НА ЗЕРНО С ПРИМЕНЕНИЕМ ВОДОСБЕРЕГАЮЩИХ ТЕХНОЛОГИЙ ОРОШЕНИЯ
Authors: Байзакова Айгуль , Калашников Александр , Б.М. Куртебаев Болат , Мамучев Руслан
Published: October 2021

В настоящее время формируются новые тенденции мировой аграрной экономики и демографии, происходят глобальные климатические изменения в сторону усиления и удлинения периода жары и засухи, что резко отрицательно сказывается на урожайности многих важнейших сельскохозяйственных культур, включая кукурузу на зерно.

Прогнозы синоптиков подтверждают, что в последующие годы жара и засуха будут все более усиливаться. В этих условиях, чтобы противостоять негативным факторам, требуется существенное изменение элементов технологии возделывания различных сельскохозяйственных культур, которые должны быть направлены в сторону снижения отрицательного воздействия критических факторов на урожайность и продуктивность.

Поэтому, совершенствование технологии возделывания сельскохозяйственных культур, с применением водосберегающих технологий орошения является важнейшей задачей современного сельскохозяйственного производства.
ИЗМЕНЕНИЕ ВОДОПОТРЕБЛЕНИЯ СЕЛЬСКОХОЗЯЙСТВЕННЫХ КУЛЬТУР В АЛМАТИНСКОЙ ОБЛАСТИ В ПЕРИОД ГЛОБАЛЬНОГО ПОТЕПЛЕНИЯ КЛИМАТА
Authors: Цхай Михаил , Кван Юрий , Калашников Павел , Калдарова Салтанат
Published: October 2021

. Климатические и погодные условия определяют условия роста, развития и формирования урожая сельскохозяйственных культур. За последние 70 лет произошли значимые изменения климата и биоклиматического потенциала территории [1]. Изменение климатических факторов (температура и влажность воздуха, осадки) предопределили важность пересмотра величин водопотребления сельскохозяйственных культур, возделываемых на территории РК.

В статье обосновывается изменения водопотребления сельскохозяйственных культур в Алматинской области на основе проведенной информационно-аналитической работы в части нормирования водопотребления и методов установления их показателей. В процессе работы проводились исследования (сбор информационных данных, анализ обобщение, систематизация) по агроклиматическим показателям, структуре посевов сельскохозяйственных культур по административным районам Алматинской области.

Корректировка норм водопотребления районированных сельскохозяйственных культур позволит сельхозтоваропроизводителям обеспечить оптимальный режим орошения и повышение урожайности сельскохозяйственных культур.
KONTEKSTUALISASI NILAI-NILAI PENDIDIKAN KI HAJAR DEWANTARA DI ERA COVID 19
Authors: Dwi Astuti Kartika , Arif Mahmud
Published: October 2021

Penjajahan memiliki dampak yang sangat kuat terhadap sistem pendidikan di Indonesia sehingga mendorong Ki Hajar Dewantara untuk melakukan langkah revolusioner untuk mengubahnya. Menurut pandangannya, sistem pendidikan Indonesia harus dibangun berdasarkan pada budaya nasional dan pengembangan karakter yang mendorong kesadaran siswa untuk memegang teguh falsafah hidup nasional. Sistem pendidikan yang mengedepankan among di antara guru dan siswa lebih cocok untuk diterapkan bagi masyarakat Indonesia. Selain itu, Ki Hajar Dewantara juga menyusun tri pusat pendidikan dan trilogi kepemimpinan pendidikan. Trilogy kepemimpinan pendidikan yang dimaksud adalaj Ing Ngarsa Sun Tulada (di depan guru memberikan teladan), Ing Madya Mangun Karsa (di tengah guru menciptakan karsa dan ide), dan Tut Wuri Handayani (di belakang guru memberikan dorongan untuk maju). Apakah nilai-nilai tersebut relevan dengan kondisi pandemi covid-19? Artikel ini menggunakan metode kajian pustaka untuk menunjukkan relevansi nilai-nilai Ki Hajar Dewantara di masa pademi. Kajian ini menunjukkan bahwa implementasi nilai-nilai pendidikan Ki Hajar Dewantara masih relevan di masa pandemic covid-19. Berdasarkan konsep tri pusat pendidikan, para orang tua merupakan pengganti guru selama belajar di rumah. Selain itu, berdasarkan trilogi kepemimpinan pendidikan, para orang tua memiliki peran yang sama dengan guru di sekolah.
STRATEGI GURU DALAM MENINGKATKAN KEMAMPUAN MEMBACA PESERTA DIDIK KELAS II SEKOLAH DASAR
Authors: Setiawan Tri Yudha Setiawan
Published: October 2021

Penelitian ini memiliki tujuan untuk mendeskripsikan tentang strategi guru dalam meningkatkan kemampuan membaca peserta didik. Penelitian ini merupakan penelitian kualitatif yang berisi tentang data deskripsi dari hasil wawancara mengenai startegi yang digunakan oleh guru dalam meningkatkan kemampuan membaca peserta didik. Penelitian dilaksanakan di kelas II Sekolah Dasar Negeri. Hasil penelitian menunjukan bahwa startegi guru yang digunakan untuk meningkatkan kemampuan membaca telah sesuai dengan kebutuhan peserta didik. Guru melakukan langkah-langkah pembelajaran dalam meningkatkan kemampuan membaca peserta didik yaitu: (1) Perencanaan pembelajaran terdiri dari persiapan media pembelajaran, materi pembelajaran yang dibuat kedalam RPP. (2) Pelaksanaan pembelajaran menggunakan strategi pembelajaran  langsung dan startegi mandiri. (3) Evaluasi pembelajaran dilihat dari hasil tes lisan.
Penggunaan Media Kartu Suku Kata untuk Meningkatkan Kemampuan Membaca Permulaan Siswa Sekolah Dasar
Authors: Yampap Umar , Hasyda Suryadin
Published: October 2021

Penelitian ini bertujuan untuk meningkatkan kemampuan membaca permulaan dengan menggunakan media kartu suku kata kelas 2 SD Inpres Kampung Baru Merauke. Jenis penelitian ini adalah penelitian tindakan kelas yang bersiklus melalui empat tahap yaitu, perencanaan, pelaksanaan, observasi, dan refleksi. Hasil penelitian dapat diketahui bahwa dengan menggunakan media kartu suku kata siklus I pertemuan I sebesar 2.45, pertemuan II 2.54. Sedangkan aktivitas siswa pertemuan pertama 2.52 dan pertemuan kedua 2.54 dengan kategori cukup aktif. Hasil nilai rata-rata kemampuan membaca permulaan siklus I sebesar 64.063 dengan kategori cukup. Keaktifan guru siklus II pertemuan I sebesar 3.65, pertemuan II 3.75 kategori sangat baik. Aktivitas siswa pertemuan I 3.55, pertemuan kedua 3.65  kategori baik. Sedangkan hasil kemampuan membaca permulaan dapat dilihat dari nilai rata-rata siklus II 75.39 kategori baik. Dengan demikian, penggunaan media kartu suku kata dapat meningkatkan kemampuan membaca permulaan siswa kelas 2 SD Inpres Kampung Baru Merauke.
Effect of X-ray radiation on the nanomechanical properties of the erythrocyte surface of rats on a high-cholesterol diet
Authors: Chelnokova I. A. , Shkliarava N. M. , Tsukanava A. U. , Nikitina I. A. , Starodubtseva M. N.
Published: October 2021

Objective.To reveal changes in the structural and nanomechanical properties of the erythrocyte surface caused by the action of X-ray radiation in vitro on the whole blood of rats on a high-cholesterol diet using the method of atomic-force microscopy.

Materials and methods.The blood of male Wistar rats being on a high-cholesterol diet for two months was exposed to X-ray radiation (320 kV) at doses of 1 and 100 Gy. The structural, elastic and adhesive properties of the surface of isolated and glutaraldehyde-fxed erythrocytes at the nanoscale were studied using the atomic- force microscope BioScope Resolve in PeakForce QNM mode in air.

Results.The study has identifed an increase in the stiffness of the erythrocyte surface at a dose of 1 Gy and its decrease to almost control values at a dose of 100 Gy, which was accompanied by an increase in the size of the average cell of the erythrocyte membrane skeleton. At the same time, no signifcant changes in the morphology, adhesive properties and roughness of the relief of erythrocytes have been found.

Conclusion.The obtained data indicate that X-ray radiation (1–100 Gy) induces the dose-depending reorganization of the structure and changes in the stiffness of the erythrocyte surface layer at the nanoscale without changing the cell morphology for rats on a high-cholesterol diet.
Features of simulation-based learning in students of medical colleges
Authors: Laptieva L. N. , Rublevskaya E. I.
Published: October 2021

Objective.To determine the order of the application of simulation-based learning (SBL) elements during the period of professional training in a medical college.

Materials and methods.We analyzed literature sources on the research problem, regulatory documents and academic programs of medical colleges, used the methods of questioning and survey.

Results.Each of the identifed stages (preclinical, clinical, professional) of the SBL model of training has its own characteristics and potentialities for the implementation of certain SBL elements. The application of SBL elements occurs in steps depending on the term of training and is aimed at overcoming diffculties arising in the process of professional adaptation.

Conclusion.The step-by-step introduction of SBL elements depending on the stages of professional adaptation in a medical college makes it possible to regulate the preparatory process for students depending on their understanding of educational material, which allows them to acquire clinical experience of professional activity during the training period and to improve psychological readiness for unsupervised professional activity.
Complicated aneurysmal bone cyst of the paranasal sinuses in a 9-year-old child
Authors: Yadchenko E. S. , Shlyaga I. D. , Radzko D. D. , Novik A. V.
Published: October 2021

Objective. To analyze a rare clinical case of the aneurysmal bone cyst (ABC) of the paranasal sinuses in a 9-year-old patient.

Materials and methods. We studied the data of the anamnesis, diagnostic and treatment methods contained in the medical history of the inpatient. We examined the patient and kept her under clinical observation during the process of the examination and treatment.

Results. The fnal diagnosis of the ABC of the paranasal sinuses in the 9-year-old patient was verifed after the obtainment of the results of the performed clinical and morphological studies. The neoplasm was surgically removed. One year after the surgery, the MRI investigation showed no relapse. The child is in a fair condition.

Conclusion. To diagnose an ABC, it is required to perform a histological examination of the tumor including the use of immunohistochemical methods.
Importance of GPER1, HO-1, HO-2 expression in the endometrium in patients with chronic endometritis
Authors: Lyzikova Yu. A. , Zinovkin D. A. , Voropaev E. V.
Published: October 2021

Objective.To evaluate the expression of G protein-coupled estrogen receptor (GPER1), heme oxygenase-1 (HO-1), and heme oxygenase-2 (HO-2) in patients with chronic endometritis and to determine the importance of these markers in the diagnosis of the disease.

Materials and methods.The results of GPER1, HO-1, and HO-2 expression were analyzed in patients with a confrmed diagnosis of chronic endometritis and in patients of the comparison group.

Results.The expression of GPER1 ≤ 79 % (sensitivity — 100.00 %; specifcity — 95.83 %; +PV — 94.00 %; -PV — 100 %), the expression of HO-1 positive cells > 5 % (sensitivity — 100.00 %; specifcity -100%; +PV — 100 %; -PV — 100 %) are signifcant for the development of chronic endometritis. The endometrial glands in the patients with chronic endometritis express the markers of inﬂammation HO-1 and HO-2 signifcantly more often than in the comparison group (p < 0.001).

Conclusion.The presented data indicate defects of the enzymes of iron metabolism and non-canonical pathways of estrogen reception in chronic endometritis. The determination of GPER1, HO-1, HO-2 expression in the endometrium in patients with chronic endometritis is a reliable criterion and may be used in the diagnosis of the disease.
Genetic control of the predisposition to suicide and aggressive behavior
Authors: Kostiuk S. A. , Davidouskij S. V. , Kostiuk D. D. , Poluyan O. S.
Published: October 2021

It has been established recently that both genes and the environment contribute to the risk of suicide. In this case, a combination of genes predisposing to certain qualities is of paramount importance. In the article, the authors provide an analytical review of literature devoted to the study of the genetic aspects of suicidality.
Increasing the effciency of spinal anesthesia in a cesarean section in pregnant women with diabetes mellitus
Authors: Rymasheuski U. V. , Kanus I. I. , Aletski V. E.
Published: October 2021

Objective. To increase the effciency of spinal anesthesia (SA) in operative delivery of pregnant women with type 1 diabetes mellitus (DM).

Materials and methods. A dynamic assessment of the clinical effciency of spinal anesthesia in cesarean sections was performed in 123 pregnant women with DM. The level of the sensor and motor block was determined depending on the dose of a 0.5% hyperbaric solution of bupivacaine calculated according to the original method.

Results. The SA method in cesarean sections in pregnant women with diabetes mellitus has been proposed taking into account the dosage of a hyperbaric solution of bupivacaine depending on the patient`s height and gestational age. The application of this method provided the development of the necessary degree of the sensory and motor block by the eight minute and created the requisite conditions for a cesarean section.

Conclusion. The proposed method of the calculation of the hyperbaric solution dosage for subarachnoid anesthesia taking into account the patients` height and gestational age makes it possible to ensure the necessary degree of the sensor block at the level of 4-5 thoracic segments and suffcient relaxation in the surgical area during a cesarean section.
Rational selection of treatment methods in recurrent clubfoot
Authors: Divovich G. V.
Published: October 2021

Objective.Based on an analytical assessment of the results of surgical treatment of children with equinovarus foot deformity of various origins (idiopathic clubfoot, syndromic clubfoot), to determine a way of rational selection of surgical techniquesin each specifc case.

Materials and methods.The results of the treatment of 78 children with congenital idiopathic clubfoot over the period 2010–2018 were assessed in comparison with the results of the treatment of 41 children with recurrent congenital clubfoot, whose primary treatment had been carried out before 2010. We have gained the experience in treating 30 children with severe clubfoot syndrome (meningomyelocele, CNS lesions, chromosomal diseases and others).

Results.In the treatment of congenital clubfoot with the Ponseti method, recurrences occur in 21.79 % of the cases, and in the traditional treatment — in 57.74 %. The Ponseti surgical treatment of recurrences consists in performing release operations on the tendon-ligament apparatus from mini-accesses. Cases of rigid, long-standing deformities require extensive releases on soft tissues, as well as resection and arthrodesis interventions on the joints of the foot. The treatment of clubfoot syndrome requires “surgically aggressive” methods of correction in early childhood.

Conclusion.In the idiopathic variants of clubfoot and its relapses, it is possible to correct the vicious position of the feet by minimally invasive operations with minimal damage to the tissues of the circumﬂex joints and without damage to the ﬂexor tendons and their sheaths in the medial ankle area. Long-standing recurrent rigid variants, as well as syndromic clubfoot, presuppose the performance of extensive releases, osteotomies and arthrodetic resections of the joints of the foot at an early age. A promising direction for clubfoot correction in the process of child development is a surgery with the use of the bone growth potential of the lower leg and foot.
INFLUENCE OF THE NATURE OF THE MODIFIER ON THE SORPTION PROPERTIES OF SHANKANAI ZEOLITE
Authors:   JSC ", Kaiynbayeva R.А. ,   Institute of Chemical Sciences named afterA.B.Bekturova, Almaty, Kazakhstan, Kojabekova N.N. ,   JSC "Institute of Chemical Sciences named afterA.B.Bekturova, Almaty, Kazakhstan, Sultanbayeva G.Sh. ,   JSC "Institute of Chemical Sciences named afterA.B.Bekturova, Almaty, Kazakhstan, Аgatayeva А.А. ,   JSC "Institute of Chemical Sciences named afterA.B.Bekturova, Almaty, Kazakhstan, Chernyakova R.М. ,   JSC "Institute of Chemical Sciences named afterA.B.Bekturova, Almaty, Kazakhstan, Jussipbekov U.Zh. ,   JSC "Institute of Chemical Sciences named afterA.B.Bekturova, Almaty, Kazakhstan
Published: October 2021

Sorbents modified with hydrochloric acid and chitosan based on the Shankanai bridge formation zeolite were obtained, and the effect of drying temperature on the sorption properties of sorbents was studied. It was found that 25 °C is the optimal temperature for obtaining acid-modified zeolite. A chitosan-modified sorbent with good sorption characteristics can be obtained at 25 °C with cation-exchange (COE 68.05 mg-eq/g) and 70°C with anion-exchange (SEC 70.16 mg-eq/g) properties. Physicochemical analysis of modified zeolites showed an increase in the size of voids and channels on the surface of acid-modified zeolite, and when modified with chitosan, the latter is crosslinked with the surface of natural zeolite.
CONVENTIONAL AND NONCONVENTIONAL METHODS OF SYNTHESIS AND GROWTH-STIMULATING ACTIVITY OF 3-CHLORO-N,N-DIETHYL-N-(2-(MESITYLAMINO)-2-OXOETHYL)PROPAN-1-AMINIUM IODIDE
Authors:   PhD  student, Dauletbakov A.A. ,   e-mail: dayletbakovanuar@gmail.com,   ORCID ID: 0000-0003-1941-6121, Belyankova E.O. ,   PhD  student;  e-mail: belyankovae@gmail.com;  ORCID  ID:  0000-0002-7418-0564, Tursynbek S.Y. ,   Kazakh-British Technical University, Department of Chemical Engineering, Almaty, Kazakhstan, Anapiyayev B.B. ,   professor; e-mail: anapiyayev@gmail.com;  ORCID  ID:  0000-0002-3130-0212, Zolotareva D.S. ,   scientific  researcher;  e-mail: zolotareva.2909@mail.ru;  ORCID ID: 0000-0002-4809-2616, Ten A.Yu. ,   Kazakh-British Technical University, Department of Chemical Engineering, Almaty, Kazakhstan, Zazybin A.G. ,   professor; e-mail: azazybin@yahoo.com;   ORCID  ID: 0000-0002-6244-9327
Published: October 2021

Synthesis of 3-chloro-N,N-diethyl-N-(2-(mesitylamino)-2-oxoethyl)propan-1-aminium iodide (1) was performed by via N-alkylation in conventional conditions and using microwave irradiation and ultrasound activation. The synthesized ionic compound was characterized using IR, 1H and 13C NMR, growth-stimulating activity had been tested for ten varieties and hybrids of sweet sorghum seeds.
PLANT SUBSTANCES AS POTENTIAL SOURCE OF ORIGINAL ANTI-VIRUS AGENTS
Authors:   JSC “International Research and Production Holding “Phytochemistry”, Karaganda, Kazakhstan, Adekenov S.M. ,   e-mail:  info@phyto.kz
Published: October 2021

This article summarizes the literature data and the results of our own studies on the search for antiviral compounds based on terpenoids, flavonoids, alkaloids. New bimolecular and ketoamide derivatives based on sesquiterpene γ-lactones arglabin, grossheimin and α-santonin were synthesized in quantitative yields up to 80%. The molecular docking method was used to study the “structure-activity” relationship of natural compounds and their derivatives in relation to SARS-Cov-2. The results obtained in silico demonstrated that sesquiterpene γ-lactones and their derivatives inhibit the SARS-Cov-2 spike protein and proteases, as well as the angiotensin-converting enzyme 2. The identified molecules can be considered as candidates for the development of new drugs with antiviral activity on their basis.
SYNTHESIS OF 1,2,3-TRIAZOLO-QUINOLIZIDINES BASED ON THE QUINOLIZIDINE ALKALOID LUPININE
Authors:   Candidate  of  Chemical  Sciences,  Leading  researcher  of  the  Laboratory  of  synthesis  of  biologically  active  substances, Nurmaganbetov Zh.S. ,   e-mail:  nzhangeldy@yandex.ru,   ORCID ID: https://orcid.org/0000-0002-0978-5663, Hurkenov O.A. ,   Doctor    of    chemical    sciences,    Professor;    e-mail: nurkenov_oral@mail.ru; ORCID ID: https://orcid.org/0000-0002-2771-0411, Fazylov S.D. ,   Academician  of  National  Academy  of  Sciences,  Doctor  of  chemical  sciences,  Professor;  e-mail:  iosu8990@mail.ru;  ORCID  ID:  https://orcid.org/0000-0002-4240-6450, Mukusheva G.K. ,   Candidate  of  Chemical  Sciences,  Leading  researcher  of  the  Laboratory  of  synthesis  of  biologically  active  substances;  e-mail:  mukusheva1977@list.ru;ORCID ID: https://orcid.org/0000-0001-6706-4816, Gazaliyev A.M. ,   Academician  of  the  National  Academy  of  Sciences  of  the  Republic  of  Kazakhstan,  Deputy  Director  for  Research;  ORCID  ID:  https://orcid.org/0000-0003-2161-0329, Muldakhmetov Z.M. ,   Academician  of  of  the  National  Academy  of  Sciences   of   the   Republic   of   Kazakhstan,   Doctor   of   Chemical   Sciences,   Professor;   e-mail: iosu.rk@mail.ru; ORCID ID: https://orcid.org/0000-0001-9497-2545
Published: October 2021

The modification of the quinolysin alkaloid lupinine was carried out with the intro-duction of 1,2,3-triazolyl substituents for the hydroxymethylene group in the C-1 position of the quinolysin backbone. The reaction of lupinine with methanesulfochloride in the presence of triethylamine smoothly led to lupinine methanesulfonate, whose further reaction with sodium azide in DMFA led to lupinilazide. 1,3-Dipolar [4+2]-cycloaddition of the resulting azide to alkynes produced more stable 1,2,3-triazole compounds. The interaction of lupinilazide with 2-ethinylpyridine and with alcohols containing a terminal acetylene group (propargyl alcohol, 2-methylbut-3-in -2-ol or hex-5-in -1-ol) proceeded smoothly in the DMFA medium. The reactions were carried out in the presence of an aqueous solution of CuSO4 and sodium ascorbate in DMFA and allowed the corresponding 4-substituted (1S,9aR)-1H-1,2,3-triazol-1-yl to be synthesized with good yields)methyl)octahydro-1H-quinolysins. The results of studying the structural features of synthesized compounds by 1H - and 13C - NMR spectroscopy, as well as data from the two-dimensional COSY (1H-1H) and HMQC (1H-13C) spectra are presented. The values of chemical shifts, multiplicity and integral intensity of 1H and 13C signals in one-dimensional NMR spectra are determined. In the spectra of all synthesized new quinolizi-dinotriazoles, there is a peak of the fragmentary C10H17N ion (150-151 cu), corresponding to the cleavage of the molecule by the C-10 atom of the quinolizidine backbone.
Mellan mission och sionism
Authors: Bengtsson Håkan
Published: October 2021

This article discusses the establishment of the Swedish Theological Institute in Jerusalem in 1951. My claim is that the missionary plan of the Swedish Mission to the Jews was mitigated towards a programme of biblical studies. Several factors contributed to this transformation. The change facilitated the relations with the Israeli authorities. Another challenge was to overcome the common Christian negative comprehension of Zionism as a mere materialistic, political enterprise. Such attitudes complicated a connection to political Zionism, however the Swedish Theological Institute related rather to the cultural Zionist agenda of promoting Jewish culture and the Bible and could later connect to the topic of the Bible and the land. The experiences of the Swedish Mission in Vienna during the Second World War and their anti-Nazi stance also en­abled the founding of the institute. Two former missionaries, Greta Andrén and Hans Kosmala, were appointed as heads of the institute. Andrén had previously experienced that missionary work in Jerusalem was considered as utterly suspicious. Thereto both the Anglican and the Swedish missionaries had under ambivalent presuppositions supported an evacuation of baptized Jews, so-called "Hebrew Christians", from Palestine to England in April and May 1948. This enterprise, named "Operation Mercy", was later proved to be primarily an excuse for these Hebrew Christians to leave the country. The links to any overt mission­ary work was thus disengaged when negotiating permits for the Swedish Theological Institute. Instead, a qualified study programme in the Bible, the land, and Judaism was initiated; concepts that reflected esteemed values of the new Israeli state.
Efectos de la actividad física en la calidad de vida de sobrevivientes de cáncer pulmonar
Authors: Pardo Gallego José Miguel , Aguirre Badillo Juan Camilo , Marcucci Campo Daniel Arturo , Cuervo Diego Mateo , Patiño Unibio Cesar Felipe , Castro Rebolledo Rodrigo
Published: October 2021

Objetivo: ​El cáncer pulmonar es una de las neoplasias más frecuentes y tiene bajas tasas de supervivencia. Se buscó identificar los efectos de la Actividad Física (AF) regular en la Calidad de Vida (CV) de los sobrevivientes de cáncer pulmonar y aclarar los parámetros de AF en términos de frecuencia, intensidad y capacidad en los pacientes con esta patología, a fin de determinar la escala más útil para evaluar la CV. Métodos: ​Se realizó una revisión narrativa, donde se recopilaron diferentes tipos de estudios. Asimismo, se eligieron estudios en los cuales se fomentaba la actividad física como un factor modificador de la calidad de vida y se analizaron los resultados que incluyeran tipo e intensidad del ejercicio y que fueran adecuados para mejorar la CV en estos pacientes. Resultados: ​Se analizaron siete artículos (cuatro observacionales prospectivos, uno experimental, uno de factibilidad - prospectivo y un estudio transversal) que emplearon diferentes escalas de calidad de vida en pacientes sobrevivientes de cáncer pulmonar. Uno empleó la escala SF-36 (Formulario Corto-36 Encuesta de salud), dos usaron la escala SF-36v2 (Formulario Corto-36 Encuesta de salud modificado), dos utilizaron LASA Score (Autoevaluación analógica lineal personal), uno empleó el QLQ-LC13 (Cuestionario calidad vida versión LC-13), el cual también incluyo la LCSS (Escala de Síntomas del Cáncer de Pulmón) y uno FACT-L (Evaluación Funcional de la Terapia de Cáncer Pulmonar). Se evidenció una mejoría en la mayoría de los subítems evaluados por cada escala de calidad de vida. El estudio reveló un aumento en la supervivencia de los pacientes que realizaron actividad física. Conclusión​: La actividad física ha mostrado un impacto positivo en la calidad de vida en los subítems destacados en el estudio y en el control de síntomas de los pacientes. Durante la revisión se concluyó que las escalas más idóneas para evaluar la CV a largo plazo y a corto plazo fueron: la escala SF-36 y la LASA score respectivamente.
Tratamiento citorreductor disponible en Colombia para la trombocitemia esencial. Revisión panorámica de la evidencia
Authors: Abello Polo Virginia , Rosales Oliveros Carmen , Gálvez Cárdenas Kenny Mauricio , Saavedra José Domingo , Duque Ortega Juan Guillermo
Published: October 2021

La trombocitemia esencial (TE) es una neoplasia mieloproliferativa crónica BCR-ABL negativa, caracterizada por la producción excesiva de plaquetas clonales. La prevalencia mundial varía, siendo aproximadamente 38 a 57 por 100.000. El tratamiento de la TE tiene como objetivo reducir el riesgo de trombosis o complicaciones hemorrágicas.Objetivo: el objetivo de la presente revisión panorámica es evaluar la evidencia actual sobre el tratamiento citoreductor de la trombocitemia esencial disponible en Colombia. Métodos: se realizó una búsqueda estructurada de literatura respecto a la efectividad y seguridad de los tratamientos citoreductores en el paciente con trombocitemia esencial. A partir de la pregunta de investigación con estructura PICO, se definieron los criterios de inclusión: pacientes con trombocitemia esencial, en manejo con Anagrelida y/o Hidroxiurea. Se incluyeron estudios de revisiones sistemáticas, metanálisis, ensayos clínicos aleatorizados. Resultados: se realizó una búsqueda en MEDLINE, EMBASE, LILACS, Cochrane Database of systematic Reviews, que arrojó 119 referencias de las cuales se incluyeron cuatro estudios, que cumplían con las características de la población, intervención y comparador. Conclusiones: la terapia citorreductora es fundamental para el manejo de la trombocitemia esencial. La evidencia sugiere que tanto Hidroxiurea como Anangrelida son agentes que brindan una protección similar contra eventos trombo-hemorrágicos clínicamente significativos.