bluuebunny/crossref_metadata_2025 huggingface dataset:
Improvement of permeable asphalt pavement by adding crumb rubber waste
Authors: Hussein Safa A. , Al-Khafaji Zainab , Alfatlawi Thair J. M. , Abbood Abdul-Kareem N.
Published: January 2023

Designing mixtures of asphalt with a porous structure to gain good trainability decreases both the propagation and generation of traffic noise. Porous asphalt (PA) mixtures use crushed stone, a small proportion of processing sand, admixtures, and asphalt binders. Therefore, this study aims to examine the impact of adding crumbed rubber into the mix of PA. However, the optimum amount of the binder used in the reference mixture without crumb rubber (CR) and the mixture with 10, 15, and 20% of crumbed rubber waste was identified by utilizing drain down. The test of Cantabro loss, air voids, and indirect tests of tensile and permeability were performed on samples to identify the influence of adding crumbed rubber on the features of the PA mixes. The optimum asphalt content achieved is 6.3%. The results indicated that CR decreases PA permeability, while the additional amount of crumbed rubber in PA negatively influences PA characteristics.
Estimation and application of matrix eigenvalues based on deep neural network
Authors: Hu Zhiying
Published: January 2023

In today’s era of rapid development in science and technology, the development of digital technology has increasingly higher requirements for data processing functions. The matrix signal commonly used in engineering applications also puts forward higher requirements for processing speed. The eigenvalues of the matrix represent many characteristics of the matrix. Its mathematical meaning represents the expansion of the inherent vector, and its physical meaning represents the spectrum of vibration. The eigenvalue of a matrix is the focus of matrix theory. The problem of matrix eigenvalues is widely used in many research fields such as physics, chemistry, and biology. A neural network is a neuron model constructed by imitating biological neural networks. Since it was proposed, the application research of its typical models, such as recurrent neural networks and cellular neural networks, has become a new hot spot. With the emergence of deep neural network theory, scholars continue to combine deep neural networks to calculate matrix eigenvalues. This article aims to study the estimation and application of matrix eigenvalues based on deep neural networks. This article introduces the related methods of matrix eigenvalue estimation based on deep neural networks, and also designs experiments to compare the time of matrix eigenvalue estimation methods based on deep neural networks and traditional algorithms. It was found that under the serial algorithm, the algorithm based on the deep neural network reduced the calculation time by about 7% compared with the traditional algorithm, and under the parallel algorithm, the calculation time was reduced by about 17%. Experiments are also designed to calculate matrix eigenvalues with Obj and recurrent neural networks (RNNS) models, which proves that the Oja algorithm is only suitable for calculating the maximum eigenvalues of non-negative matrices, while RNNS is commonly used in general models.
Sonic hedgehog N-terminal level correlates with adiponectin level and insulin resistance in adolescents
Authors: Takaya Junji , Tanabe Yuko , Kaneko Kazunari
Published: December 2022

Objectives

Extracellular vesicles (EVs) are small vesicles released by nearly all types of cells. They deliver different types of substances, including proteins and nucleic acids, to nearby or distant cells and play a role in the mediation of cell-to-cell communication. The aim of this study was to explore the association between EVs and insulin resistance in adolescents with obesity or type 2 diabetes mellitus (DM2).

Methods

The subjects were eight adolescents with DM2 (DM2 group; four males and four females; age: 18.1 ± 2.3 years), 18 adolescents with simple obesity (obesity group; 12 males and six females; age: 12.2 ± 3.4 years), and 20 controls (control group; 10 males and 10 females; age: 13.0 ± 1.4 years). As markers of EVs, serum CD9/CD63 and sonic hedgehog N-terminal (Shh-N) levels were measured using enzyme-linked immunosorbent assay.

Results

The CD9/CD63 level in the control group was similar to that in the DM2 group, whereas the obesity group had a significantly higher CD9/CD63 level. In the entire study group, correlations were observed between serum Shh-N level and Homeostasis Model Assessment of insulin resistance (HOMA-IR) score (r=0.371, p=0.0143), Homeostasis Model Assessment-β cell function score (r=0.382, p=0.0115), serum insulin level (r=0.350, p=0.0171), and serum adiponectin level (r=0.367, p=0.0122). Multiple regression analysis revealed that serum Shh-N level was the most significant risk factor for HOMA-IR score and serum insulin level.

Conclusions

Shh is correlated with insulin resistance via its association with adiponectin in adolescents.
Phrasal subcomparatives: a comparative coordination analysis based on evidence from Basque, Spanish, and English
Authors: Vela-Plo Laura
Published: January 2023

By analyzing an understudied type of comparative, namely, subcomparatives with surface-phrasal standards of comparison, this article offers an answer to three long-debated questions regarding the internal structure and semantic composition of comparative constructions in opposition to traditional assumptions and reductionist analyses. First I offer syntactic tests evidencing the non-clausal status of the standard in these subcomparatives in Basque, Spanish and English. Second, regarding the question of the linkage type between the compared elements (either a dependence relation or a coordination relation), I present previous and novel syntactic evidence showing that phrasal subcomparatives invariably behave like common phrasal coordinates. Therefore, I defend an architecture of these comparatives involving a phrasal coordinate structure and offer a transparent mapping between the surface syntax and semantic interpretation of these constructions. Third, subcomparatives involve the obligatory omission of a measure modifier from the standard. This process known ascomparative subdeletioncannot be explained as the result ofwh-movement within a clause, given the non-clausal status of the standard. Alternatively, comparative subdeletion is defined not as anad hocdeletion rule but rather as the result of an obligatory deletion operation independently attested in common coordinate structures.
Study on r-truncated degenerate Stirling numbers of the second kind
Authors: Kim Taekyun , Kim Dae San , Kim Hyekyung
Published: January 2023

The degenerate Stirling numbers of the second kind and of the first kind, which are, respectively, degenerate versions of the Stirling numbers of the second kind and of the first kind, appear frequently when we study various degenerate versions of some special numbers and polynomials. The aim of this article is to consider the r-truncated degenerate Stirling numbers of the second kind, which reduce to the degenerate Stirling numbers of the second for r = 1, and to investigate their explicit expressions, some properties and related identities, in connection with several other degenerate special numbers and polynomials.
Synthesis of PEITC-loaded gold nanoparticles and evaluation of the hepatoprotective effect on CCl4-induced damage through Nrf2 pathway
Authors: Uyumlu Ayşe Burçin , Çağlar Yılmaz Hatice , Satılmış Basri , Erdemoğlu Sema
Published: January 2023

Objectives

The purpose of the study was to prepare an effective and new drug delivery system for enhancing the stability of Phenethyl isothiocyanate (PEITC), and its hepatoprotective effect in the carbon tetrachloride (CCl4)-induced damage in hepatocellular carcinoma G2 (HepG2) cell line via nuclear factor (erythroid-derived 2)-like 2 (Nrf2) pathway.

Methods

Gold nanoparticles were synthesized and then characterized by XRD, SEM, SEM-EDX analysis, hydrodynamic diameter and zeta potential measurements. 1.0024 mM PEITC, a naturally occurring isothiocyanate, an active ingredient was loaded onto the characterized AuNPs. The cytotoxicity test of PEITC-AuNP and effects on ALT, AST, Nrf2 levels and total antioxidant capacity (TAC) of CCI4-induced HepG2 cells were investigated.

Results

PEITC-AuNPs and PEITC decreased ALT and AST levels (p<0.05). This reduction was greater with PEITC-AuNPs. PEITC-AuNPs increased Nrf2 level but it was nonsignificantly (p>0.05). PEITC didn’t increase the Nrf2 level in CCI4-induced HepG2 cells. TAC of both PEITC-AuNPs and PEITC administration increased significantly compared with CCl4 group (p<0.05). But PEITC-AuNPs enhanced the TAC level higher than PEITC significantly (p<0.05).

Conclusions

PEITC-AuNPs were more effective than PEITC which resulted in more hepatoprotective and antioxidant effects via Nrf2 activation against CCl4-induced liver injury in HepG2 cells.
Implementation of The Use Maternal and Child Health (MCH) Handbook
Authors: Kurnain Nadaa Julia , Zirmansyah Zirmansyah , Nurfadilah Nurfadilah
Published: December 2022

Health is one of the things that must reck in fulfill of child development. The aims the study is to find out implementation of the use Maternal and Child Health (MCH) Handbook in BKB PAUD Teratai Putih, Kuningan, South Jakarta. This research used a phenomenological qualitative method. This subject is the research were 1 principal, 3 teachers and 3 mothers in BKB PAUD Teratai Putih. The result of this study showed that (1) The three teachers and mothers (parents of students) BKB PAUD Teratai Putih very well know the MCH Handbook, they can apply the MCH Handbook according to the instructions. (2) The MCH Handbook is implemented in the activities of visits to posyandu, visits of health workers to schools, habituation of the clean and healthy behavior, school promotion and child development reports, reporting of child development achievement levels and parenting using the MCH Handbook as an information tool, monitoring growth and development. children, recording health services and communication tools, (3) Supporting factors in implementing the use of the MCH Handbook are cadres who are also teachers to make communication easier so that they can work together with parents in caring for and developing children's growth and development and one of the inhibiting factors is when There are parents who do not bring the MCH Handbook during the posyandu activities because they are missing or damaged.
Polemic and Reasons for Reusing Wayang and Gamelan as A Medium for Contemporary Preaching Islam Religion in Central Java, Indonesia
Authors: Setiawan Aris
Published: December 2022

This study aims to reveal the main reasons why wayang kulit (shadow puppets) and gamelan music were used again as tools of Islamic da’wah after the Wali Sanga era (Nine Saints). In Central Java (Banyumas, Solo, Demak, Pati), there has been a phenomenon of Islamic preaching and recitation performed by Kiai using wayang kulit and gamelan music. This study uses a phenomenological approach, which is to get an explanation of the apparent reality. This approach focuses on events that are seen as having an impact, polemic, and discourse on life. This study also uses a critical approach, looking critically at the phenomenon of -art- being researched to test how far the view that puts that wayang (and gamelan) is not by religious rules is accepted, rejected, and even opposed. The result shows that although da’wah using wayang and gamelan has sparked a lot of polemics, the use of wayang and gamelan music is considered more effective in spreading Islamic teachings to grassroots communities due to two factors. First, continuing the trace of tradition brought by the first Islamic missionaries in Java (Wali Sanga). Second, to make people aware, especially young santri (prospective preachers) or congregation today, realize that Islam is spread peacefully and without resistance through art.
Luwes and Philosophical: Dewaruci Puppet Performance in Suryomentaram’s Kasampurnan Concept
Authors: Zustiyantoro Dhoni , Nuryatin Agus , Supriyanto Teguh , Doyin Mukh
Published: December 2022

This study explores the performance of Ki Manteb Soedarsono’s Dewaruci and Bima characters in it. As a carangan play (contemporary), Dewaruci is the most popular play. The purpose of this study is to describe the elements of Dewaruci puppet performance and how the concept of kasampurnan in Javanese cultural psychology was initiated by Suryomentaram (1892-1962). This is qualitative research with a psychological approach using the method of reading, taking notes, and studying literature. The data in a form of performances and texts were collected from Dewaruci scripts and puppet videos on Kanal Seni Gelar YouTube channel. We combine Dewaruci script with the puppeteer Ki Manteb and other sources, in addition, to conduct a critical analysis to identify kasampurnan life concept that Bima does in this play from Suryomentaram’s perspective. The result of the study shows that the Dewaruci puppet show by Ki Manteb has the advantage of being flexible and able to adapt to the context and needs of the audience. The concept of kasampurnan in Dewaruci as a representation of Javanese culture can be explained from the perspective of Suryomentaram indigenous psychology. This finding contradicts previous psychological analyses in literature and art. Previous psychology research used the theory of Sigmund Freud, C. G. Jung, and Alfred Adler. However, we argue that the theory cannot always explain the cultural context because of cultural differences between theory and objects. Therefore, this research is relevant in the spirit of science decolonization to see humans in Javanese culture according to their context and culture.
Children’s Trilingual Songs (Indonesian, English, and Javanese) as Media for Strengthening the Diversity Character of Elementary School Students
Authors: Sinaga Syahrul Syah
Published: December 2022

Bhineka Tunggal Ika reflects national identity, which contains cultural diversity values in Indonesia. Issues of intolerance and globalization often found in Indonesia are the main reasons for instilling children’s character values about diversity through children’s trilingual songs. This study aims to create and develop children’s songs in three languages (trilingual), namely Indonesian, English, and Javanese, as an effort to strengthen children’s character about tolerance and diversity. This research is a type of research and development (RD) using the ASSURE model by combining qualitative and quantitative methods (mixed method). Data collection was carried out using the method of observation, interviews, and written input on the assessment sheet. Meanwhile, quantitative data is collected through questionnaires and assessment sheets in percentage values from experts and users. The results of the study show that the song “Harmony in Diversity” can be used as an educational medium in educating children to have a global outlook but still love the national language and preserve regional languages. This is because they have studied, expressed, and appreciated songs with trilingual meanings and lyrics. The children’s song “Harmoni dalam Keberagaman” is declared feasible and applicable for learning at the elementary school level. This is evidenced by the data validation results, which show that all indicators, namely song components, language, appearance, audiovisual media engineering, and implementation, get very feasible criteria, with an average score of 89.59%. The aspect that gets the highest score is the display aspect, with a score of 90.48%, and the aspect with the lowest percentage is the visual media design component and the song component, with a score of 87.5%..
Pengaruh Konsep Diri dan Kreativitas Siswa Terhadap Prestasi Belajar Siswa dengan Menerapkan Pendekatan Kontekstual Pada Materi Termokimia
Authors: Seran Engelbertus Dedycandro
Published: January 2023

The aims of this study were (1) to determine the effectiveness of the application of a contextual approach to the subject matter of thermochemistry onstudent achievement in the odd semester students of class XI Science at Warta-Bakti High School Kefamenanu. (2) Knowing whether or not there is a relations between, self-concept and student creativity onstudent achievement by applying a contextual approach, to the subject matter of thermochemistry in class XI IPA SMA Warta-Bakti Kefamenanu. (3) Determine whether there is an influence of self-concept and student creativity onstudent achievement on the subject matter of thermochemistry. The variables in this study consisted of two independent variables, namely self-concept and student creativity and the dependent variable, namely student achievement. The analytical method used in this research is descriptive analysis and statistical analysis. From the data analysis obtained: (1). completeness of affective learning outcomes of 87%, completeness of cognitive learning outcomes of 85.11%, completeness of psychomotor learning outcomes on average of 87.70% and completeness of learning outcomes as a whole is said to be complete with a percentage of 86.12 %. C. Students' self concept and creativity are said to be very good, with an average of 86.85% and 86.14%, respectively. (2) Based on the calculation obtained Rxy = 0.8, the large contribution of variable X to variable Y is 64% and Ttable = 3.59, because Tcount ≥ Ttable is 9.64 3.59 then Ha is accepted and, Ho is rejected, which means, there is a relations between self-concept and student creativity on student achievement by applying a contextual approach, (3) There is an influence of self-concept and student creativity on student achievement by applying a contextual approach where, Fcount ≥ Ftable, which is 15.11≥3.59 at dk = 2 and dk = 20 at a significant level of 5%, then Ho is rejected and Ha is accepted.Keywords: Self-Concept, Creativity, Student Achievement, Contextual Approach.
Analisis Miskonsepsi Kimia dan Instrumen Diagnosisnya: Literatur Review
Authors: Rokhim Deni Ainur , Rahayu Sri , Dasna I Wayan
Published: January 2023

Penelitian ini bertujuan untuk menganalisis trend penelitian miskonsepsi kimia peserta didik pada tingkat SMA dan instrumen diagnosisnya. Metode penelitian ini menggunakan metode Systematic Literature Review (SLR). Data penelitian diperoleh, dari 20 artikel yang diseleksi pada basis data Eric, Scopus, Google Schoolar, Crosccef yang terindikasi dari tahun 2015 hingga 2021. Artikel yang dipilih memiliki kesamaan topik terhadap analisis miskonsepsi. Hasil analisis data menunjukkan bahwa publikasi artikel miskonsepsi peserta didik di tingkat SMA enam tahun terakhir mengalami penurunan miskonsepsi, dan ditemukan lagi miskonsepsi yang lain, yang berarti penelitian miskonsepsi masih menjadi fokus penelitian saat ini dan masalah miskonsepsi kimia masih sering terjadi pada peserta didik SMA. Penyebab miskonsepsi kimia pada peserta didik mayoritas terjadi karena faktor internal berupa ketidaksesuaian prakonsepsi peserta didik dengan konsep ilmuwan. Pengembangan instrumen diagnostik yang digunakan tes Two-Tier, tes Three-Tier, tes Four-Tier, tes Five-Tier, Kuesioner dan soal pilihan ganda bersifat open –ended Jager, dan Essay Diagnostic Test of Chemistry merupakan metode untuk mendeteksi miskonsepsi kimia yang sering dikembangkan dalam penelitian. Selain itu, penelitian ini juga mengungkap bahwa tidak ada perbedaan hasil tentang instrumen yang digunakan dan miskonsepsi yang ditemukan antar lintas negara
Weakly symmetric functions on spaces of Lebesgue integrable functions
Authors: Vasylyshyn T.V. , Zahorodniuk V.A.
Published: December 2022

In this work, we present the notion of a weakly symmetric function. We show that the subset of all weakly symmetric elements of an arbitrary vector space of functions is a vector space itself. Moreover, the subset of all weakly symmetric elements of some algebra of functions is an algebra. Also we consider weakly symmetric functions on the complex Banach space $L_p[0,1]$ of all Lebesgue measurable complex-valued functions on $[0,1]$ for which the $p$th power of the absolute value is Lebesgue integrable. We show that every continuous linear functional on $L_p[0,1],$ where $p\in (1,+\infty),$ can be approximated by weakly symmetric continuous linear functionals.
A new kind of soft algebraic structures: bipolar soft Lie algebras
Authors: Çıtak F.
Published: December 2022

In this paper, basic concepts of soft set theory was mentioned. Then, bipolar soft Lie algebra and bipolar soft Lie ideal were defined with the help of soft sets. Some algebraic properties of the new concepts were investigated. The relationship between the two structures were analyzed. Also, it was proved that the level cuts of a bipolar soft Lie algebra were Lie subalgebras of a Lie algebra by the new definitions. After then, soft image and soft preimage of a bipolar soft Lie algebra/ideal were proved to be a bipolar soft Lie algebra/ideal.
Generalized integral type mappings on orthogonal metric spaces
Authors: Acar Ö. , Erdoğan E. , Özkapu A.S.
Published: December 2022

This study is devoted to investigate the problem whether the existence and uniqueness of integral type contraction mappings on orthogonal metric spaces. At the end, we give an example to illustrative our main result.
Pathogenesis and Nutritional Intervention of Chronic Obstructive Pulmonary Disease-Associated Frailty
Authors: Heo Jung
Published: December 2022

Frailty, as a type of geriatric condition, has been a major focus of geriatrics researchers in recent years. COPD is one of the major risk factors associated with frailty. Consequently, chronic obstructive pulmonary disease-related frailty has become the focal point of numerous investigations. However, the majority of studies focus on cross-sectional investigations of the incidence of frailty in COPD and their associations. The study of its pathophysiology and intervention methods is dispersed, and there is a paucity of literature reviews. Moreover, in-depth research into the pathophysiology of such patients and the implementation of efficient therapeutic strategies are crucial for enhancing the long-term quality of life of patients. The purpose of this article is to provide a reference for creating nutritional intervention programs for chronic obstructive pulmonary disease and a debilitated population by describing the etiology of these patients and summarizing potential nutritional therapies based on recent research.
Sacred corruption in sacred places: the case of some selected Neo Pentecostal Churches in Nigeria
Authors: Olalekan Dairo Afolorunso
Published: December 2022

It is no longer news that corruption is a persistent phenomenon in Nigeria; in which there is official misuse of funds and resources. If dishonesty or fraudulent practices are found in the mist of those in political power and among public servants, should such then be found in a place where the agitation day and night is on “holiness unto the Lord”? When “sacred corruption are found where the “so called people of God” dwells, then such a country is finished. The Church should be the precursor of anti-corruption campaign. But unfortunately, corruption in the Church is “a new thinking in reverse order”. Corruption in today’s Church takes many forms and can be interpreted in various ways. The faces of corruption in the Church are many. These as observed in this paper includes, misinterpretation of the word of God to suit their purposes, extortion, ethical problems, charismagic and so forth. The paper then examines the high rate of corruption in some selected new generation Churches in Ibadan Metropolis; with the view to establishing the level of greed and how efforts to maintain self-imposed ostentatious life style leads them into “sacred corruption in sacred places”. Phenomenological and descriptive methods were employed in carrying out the research. It is our belief that the results of the research will go a long way in reducing the level of “sacred corruption in sacred places” in Nigeria.
A review of the human resource management dilemma for SMEs: case of central Uganda
Authors: Basika Elisa , Mutumba Raymonds , Menya James , Kabeng Isa , Kiggundu Nicholas , Oshaba Brenda
Published: December 2022

The increasing interest in human resource practices is driven by the hypothesis that employees and their management are critical to the success of an organization. Small and medium enterprises (SMEs) contribute significantly to several countries’ economies in terms of gross domestic product, employment fraction and exports. Human resource management (HRM) on the other hand plays a pivotal role in the growth and survival of SMEs if systematically understood and implemented in these businesses. As such, this paper aims to analyze factors that affect successful HRM and implementation in small and medium enterprises. Our findings demonstrate that SMEs need to make an effort to close the gap between demand and supply of labor for them to be able to compete with larger firms in the market. We conclude that the factors that affect human resource management are mainly due to the internal organization of these businesses and if HRM is properly implemented, it almost guarantees sustainability and competitive advantage of small firms. An “employee retention model” was formulated which can be used by SMEs to guide the retention of employees hence reducing staff turnover.
Thinking about Japan’s future public health policy from data-driven reforms and social security reforms
Authors: Tomoko Tachibana
Published: December 2022

This study examine what should be promoted in future public health policies from the perspective of "social security reform / data-driven reform" that we are promoting. The new Society 5.0, which Japan is aiming for in the future, is a human-centered society that achieves both economic development and resolution of social issues through a system that highly integrates cyber space (virtual space) and physical space (real space). The field of disability health, where data is overwhelmingly scarce, is an international subject of public health. The WHO Secretariat should play a role as a member state in the "report of the highest health standards reachable by persons with disabilities" required by the end of 2022. We propose to contribute to the enhancement of the social security system with the aim of becoming a "health data system in a value co-creation type community symbiotic society" through a health monitoring system and PHR that utilize mobile devices, by further promoting social security reform by transforming into the latest data-driven organization.
Distribution of ear, nose and throat (ENT) lesions: an eleven year retrospective study
Authors: Macdonald Dike , J Ayodele Omotoso , I Theophilus Ugbem , Ernest Naomi
Published: December 2022

Aim/objective: The study is to determine the distribution of Ear, Nose and Throat lesions in the university of Calabar Teaching hospital (UCTH) as recorded in the Department of Pathology. Background: Ear, nose, and throat (ENT) diseases are responsible for considerable morbidity among infants and young children. Acute infections of upper respiratory as well as recurrent disease and disorder of Ear, Nose and Throat are more common in early stages of life. In developing countries, otorhinolaryngological services are overcrowded, with patients suffering from acute and chronic complaints. Methodology: The study consists of all patients who presented ENT lesions seen in the pathology Department of University of Calabar Teaching Hospital from 2009-2019. The data obtained was analysed Results: The data collected were for a period of eleven years (2009-2019). A total of 1051 lesions were seen. Adenoid and tonsil (throat) were the most common lesion; followed by nasal and paranasal sinus and then other regions. There were more benign lesions than malignant and inflammatory. The peak incidence of the lesions was in 2012. Conclusion: Our study showed throat as the most common location of ENT lesion. There is a need for the Nigerian otolaryngologist to embark on a national survey of ENT diseases, so as to find the probable aetiological factors, establish regional variation in the incidence of ENT diseases and to stimulate research into the development of preventive measures.
Relationship of help in the community outpatient program for people in situation with predatory consumption and / or dependence on alcohol and other drugs: a case study in the municipality of osorno, Chile
Authors: Pérez Aros Silvia Andrea , Constanzo Alba Zambrano
Published: December 2022

The People in Situation of Calle are one of the most vulnerable groups in terms of physical and mental health. In Chile, around the middle of them present problems with the consumption of substances, increasing its condition of social exclusion. To obtain a comprehensive measure of the mode in which the assistance relationship is established with persons in a situation where the prejudicial consumption of alcohol and other drugs is aborted, from the perspective of women interviewed in a psychosocial intervention program in Chile, the way in which the intervention in practice is configured. For this purpose, a case study of a program is carried out, conducting semi-structured interviews with the integrants of the psychosocial intervention team. Complementary documentary analysis of program acts and information was carried out. The main results are arrojan that, in the configuration of the relationship of ayuda, the emotional and relational angle that is established with the users of the daily support, the active listening, the empathy, are the central elements for the development of the work that allows users to adhere to their treatment plan. These dimensions are complementary to work routines with institutional redundancies for better logarization of the living conditions of the people involved in the program are the key elements for the development of a psychosocial intervention that allows users to adhere to their treatment plan. These dimensions are complementary to work routines with institutional redundancies for better logarization of the living conditions of the people involved in the program are the key elements for the development of a psychosocial intervention that allows users to adhere to their treatment plan. These dimensions are complementary to work routines with institutional redundancies for better logarization of the living conditions of the people involved in the program.
Effect of the application of organic amendment and microorganisms that promote plant growth on tomato production (Solanum lycopersicum L.)
Authors: Andrada Horacio , Barbaro Gabriela Di , Basso Valeria Gonzalez , Viale Sixto , Felicetti Julieta
Published: December 2022

It is important to conserve and improve water use efficiency and crop productivity in arid and semi-arid zones. For which, the use of beneficial microorganisms and water retainers can help in the tolerance of plants to drought conditions. Therefore, the objective of this work was to determine the effect of inoculation with MPCV- plant growth promoting microorganisms (Azospirillum brasilense and mycorrhizal fungi) and the application of organic amendment of potassium acrylate on the production of tomato plants (Solanum lycopersicum L.). A greenhouse trial was carried out with a completely randomized experimental design with 4 treatments (T1: Control without application of amendment or MPCV; T2: application of K acrylate amendment; T3: with MPCV inoculation; T4: with joint application of K acrylate amendment and MPCV), with 15 replicates. The highest production and size of tomato fruits was achieved with the inoculation of MPCV (T3) and with the application of K acrylate (T2) individually. The inoculation with Azospirillum brasilense and mycorrhizal fungi, and the application of the organic amendment of potassium acrylate at the time of transplanting tomato (Solanum lycopersicum L.) improves growth and increases its production.
A retrospective study assessing different techniques for Suprascapular Nerve Block for chronic shoulder pain
Authors: Azher Imran , Bustamante Sara
Published: December 2022

Shoulder pain is a common complaint associated with significant pain and disability. Chronic shoulder pain is common cause of functional disability in the community. A supra scapular nerve block is a safe and effective technique for treatment of both acute and chronic shoulder pain, resulting from inflammatory and degenerative disorders. It can be done using a number of different techniques including but not limited to landmark technique, USG guided, X-ray guided and CT guided and PRF. Methods: We did a retrospective study looking at efficacy of supra-scapular nerve block done in our centre over the last 2 years using different techniques. We audited a total of 80 procedures over two years. We looked at effective pain relief and any potential complications over 3- 6 months. Result and conclusion: This was a retrospective study looking at a number of patients over 2 years having had multiple procedures. Because of the nature and the limitations of an audit, it was not possible to suggest that any particular technique is superior over the other. We need to do at prospective study with better randomization, follow up and more specific disability and pain scoring tools like shoulder pain and disability index (SPADI) and VAS scoring systems.
Revisiting the proposed hypotheses for trigeminal neuralgia with a note on its co-existence with Glossopharyngeal neuralgia. a review
Authors: Gautam Dr. R K , Paswan Dr. A K
Published: December 2022

Objective – to summarize the various hypotheses regarding the development of Trigeminal Neuralgia with a brief discussion about the causes for its co-existence with Glossopharyngeal Neuralgia, which has been seen infrequently. Summary of background - Cranial nerve neuralgia is one of the most common pain syndromes attributed to the extreme (extremely) detrimental effects on middle age population who are more productive. The first documentation of Trigeminal neuralgia (TN) dates back second century AD by Aretaeus of Cappadocia, a contemporary of Galen.1 A study conducted from 1992 to 2002 in the UK reported an incidence of 26 per 100000 population per year.2 Its incidence is more prevalent amongst (the) female population with the ratio of 1.7:1, and increases with the age. The purpose of my paper is to summarise all the possible mechanisms that lead to the development of Trigeminal neuralgia and to create an update regarding what we know about it now. My paper would also like to explore certain possibilities, which according to me, is (are) responsible for its infrequent occurrence with Glossopharyngeal neuralgia.
Cardiorespiratory parameters monitoring during moderate sedation at different oxygen flow rates in patients undergoing endoscopic intervention
Authors: Zekry Attia Josef , A.M. Hassanin Abeer
Published: December 2022

Background: Cardiorespiratory parameters before, during and after administration of sedation/analgesia in patients undergone endoscopic procedure should have monitored. Aim of the study: In this study we evaluated the effect of different O2 flow rates on the non-invasive CO2 monitoring (EtCO2) in patients that are breathing spontaneously under moderate sedation undergoing endoscopic procedures. Methods: 120 patients of both sexes aged between 25 and 60 years with ASA- I and II scheduled for undergoing upper GIT endoscopy for gastric ulcer patients. Patients were randomized to three equal groups. Group I: 40 patients will receive O2 supply at rate of 2 liters per minute and then cabnographic and other measures will be recorded throughout the procedure. Group II: 40 patients will receive O2 supply at rate 4 liters per minute and then cabnographic and other measures will be recorded throughout the procedure. Group III: 40 patients will receive O2 supply at rate 6 liters per minute and then cabnographic and other measures will be recorded throughout the procedure. Results: EtCO2 differences between the three studied groups were statistically significant at preoperative, induction, 5, 10, 20 and 30 min but with no any clinical significance or adverse outcome. HR, MBP, RR and Spo2 difference between group were statistically insignificant throughout the procedure with no serious complications were recorded and patients satisfaction results were comparable between the three studied groups. Conclusion: Our study demonstrated that different O2 flow rates did not affect noninvasive EtCO2 measurement during moderate sedation in patients undergoing upper GIT endoscopy for gastric ulcer patients.
Posterior reversible encephalopathy syndrome in a patient with mixed connective tissue disorder: a case report
Authors: Khanal Sushil , KC Kripa , Shrestha Marisha , Sainju Chandani
Published: December 2022

Our case report includes a 42-year-old female patient; a known case of Mixed Connective Tissue Disorder (MCTD) who presented with focal seizure. Magnetic Resonance Imaging (MRI) brain showed the features of Posterior Reversible Encephalopathy syndrome (PRES) to be the cause of seizure. Given the timely diagnosis of PRES, the seizure was controlled with anti-epileptic drug and the possibility of having poor neurological outcome was successfully prevented. Although Mixed Connective Tissue Disorder is rarely associated with PRES, MCTD should be considered when there are supportive clinical and radiological findings as in our case.
Food-borne pathogens survival of Yersinia enterocolitica and molecular analysis of 16SrRNA sequencing of Salmonella typhi & Salmonella enterica from frozen buffalo meat in India
Authors: Sen Ujjal , Vishnoi Nidhi , Garode Anil Mahadeo
Published: December 2022

French Bacteriologist Alexander Yersinia in 1894 first described Yersinia eniterocolitica as causative organisms for food-borne illness. Yersinia enterocolitica is an enteropathogenic organism and causes “yersiniosis” that denotes infections such as, gastroenteritis in infants and young children and it considered as bacillary dysentery or campylobacter - like enterocolitis with abdominal pain and diarrhea. Even it give rise to acute terminal ileitis or mesenteric lymphadenitis, cause septicemia with high fatality rate, abortion, pneumonia, ileocaecal appendix, proximal colon level, acute enterocolitis, immunological complications like erythema nodosum, polyarthritis, Reiter’s syndrome, some time leading to death etc. In frozen buffalo meat at very freezing temperature the organisms common and isolated can cause spoilage. Y. enterocolitica is gram negative, pleomorphic, asporogenous short, capsulated, motile with peritrichous flagella microscopically and grown at 22oC. Y. enterocolitica is aerobe and facultative anaerobe and actively porn to zoonosis. Salmonella species also a risky food borne pathogen and causes typhoid and salmonellosis. In present research investigation 51 samples of frozen buffalo meat processed microbiologically whereas 39 samples are positive and 11 samples are negative for Y. enterocolitica. Hence, It is observed load of tolerance are in littile higher in frozen meat. MacConkey agar showed as small, irregular, pinpointed, pinkish - reddish or pale pink or reject red color lactose negative colonies at 37oC and form pinpoint colonies at 22oC. Antibiotic assay test of Y. enterocolitica revealed that 10µg amoxyclave disc is sensitive to Y. enterocolitica but, 5µg methicillin disc is resistant to Y. enterocolitica. The positive Salmonella species colonies from specific media such as (e.g. XLD, BGA, BSA, HEA) isolated and subjected to molecular analysis of 16SrRNA sequencing identified as Salmonella typhi strain T9 16S ribosomal RNA gene, partial sequence and Salmonella enterica subsp. enterica serovar enteritidis strain DY60 16S ribosomal RNA gene, partial sequence, causes the spoilage in meat at low temperature and threaten public health safety. The overall result indicates poor management of hygiene at abattoir and inefficient cleaning condition can augment low temperature spoilage of meat and serious issue for the reassessment of public health importance.
INFLUENCE OF THE LIPID COMPOSITION ON THE PROPERTIES, TECHNOLOGY AND QUALITY INDICATORS OF LIPOSOMAL DRUGS
Authors:   State Biotechnological University, Ukraine, Kharkiv, Pylypenko D. М.
Published: January 2023

Liposomal drug delivery system is an example of the use of nanodrugs in medical practice. Encapsulation of active pharmaceutical ingredients in liposomal nanoparticles allows increasing their bioavailability and efficacy. Aim. The article is devoted to the analysis of the lipid composition of liposomal drugs developed in Ukraine, its influence on the choice of technology and control parameters. Results. The lipid compositions of liposomal drugs developed in Ukraine in recent years were reviewed. The advantages and disadvantages of natural phosphatidylcholine as the main membrane-forming lipid were analyzed. Data on the influence of anionic phospholipids and cholesterol in the liposomal membrane composition on the stability of liposomal nanoparticles and the level of active pharmaceutical ingredient encapsulation were given. The main technological stages of obtaining liposomes with hydrophilic and hydrophobic active pharmaceutical ingredients were considered. The main groups of quality indicators of liposomal dosage forms have been determined. Conclusions. The lipid composition determines the structure and physicochemical properties of the lipid membrane, the mechanism and level of active pharmaceutical ingredient encapsulation, which significantly influences the pharmacological efficacy of liposomal drug delivery systems.
PHYTOCHEMICAL CONSTITUENTS AND ANTILEUKEMIC EFFECTS OF JUNIPERUS OXYCEDRUS EXTRACT
Authors:   Department of Bioengineering, Faculty of Engineering and Natural Sciences, Üsküdar University, Istanbul, Turkey., TURAK Berfin Tugba
Published: January 2023

Aim: Many genetic and environmental factors can be effective in the process of cancerization. Preventing the progression of leukemia may be possible by controlling the pathways involving mechanisms such as apoptosis and autophagy. When the literature is examined, there are studies showing the effects of various types of juniper on various cancer cell lines, including human chronic myeloid leukemia cells, but the signal pathways in which they act are not fully known. In this study, the anticancer effects of Juniperus oxycedrus extract on K-562 human chronic myeloid leukemia cells were investigated. Method: After the cells were treated with the Juniperus oxycedrus extract, cytotoxicity and gene expression analyzes were performed. Changes in the expression of Akt, the member of the PI3K/Akt/mTOR signaling pathway; caspase 3, which is one of the main effective genes in the pathways regulating apoptosis; and the apoptosis suppressor BCL-2 gene, which is an oncogene, were investigated. Results: According to the MTT test results, Juniperus oxycedrus extract showed over approximately 50% cell viability in K-562 cells at all doses. The most appropriate dose of Juniperus oxycedrus fruit extract in this research was determined as 50 µg/ mL considering cell viability. After the gene expression analysis, it was observed that Akt expression increased 1.092 times, BCL-2 expression decreased approximately 0.3 times, and caspase 3 expression increased 1.2 times. Conclusions: Constituents of Juniperus oxycedrus plant may have apoptotic effects on chronic myeloid leukemia cells.
Effect of Carbonization Temperature on Properties of Char from Canarium schweinfhurthii (Atili) Seed Shell.
Authors:   Chemistry Advanced Research Center, Sheda Science and Technology Complex, Abuja, Sallau Alhassan , Hassan Umar ,   Department of Chemistry, Abubakar Tafawa Balewa University Bauchi, Bauchi State., Kolo Alhaji ,   Department of Chemistry, Abubakar Tafawa Balewa University Bauchi, Bauchi State, Jauro Aliyu ,   National Environmental Standards and Regulations Enforcement Agency (NESREA), Abuja, Ekanem Okon ,   Department of Chemistry, Federal University Otuoke, Bayelsa State
Published: December 2022

The effect of carbonization temperature on canarium schweinfhurthii seed shell was investigated. Atili seed shell particles was carbonized at different temperatures of 600, 800, 1000 and 1150°C under inert condition for 60 mins each to obtain char products. The effect of temperature on the properties of char was investigated in detail, using several characterization techniques including, mass yield, elemental analysis, and electrical property measurements while structural transformations were monitored using X-ray diffraction, Fourier transform infrared (FTIR) spectroscopy and scanning electron microscope (SEM) techniques. The char yield decreased from 30.50 % to 26.55 % as the temperature increases from 600°C to 1150°C. The fixed carbon (82.3 to 92.66 %) and ash content (1.35 to 1.72 %) increase as temperature increase while the volatile matter (12.61 to 4.18 %) and moisture content (3.81 to 1.44 %) decreases. Ultimate analysis showed elemental carbon to increase from 85.96 % to 95.79 %. The electrical conductivity of obtained char improved significantly (1.99 x 10-9 to 7.24 x 10-2 S/cm) as well as the structural, morphology and near graphitization of char. Statistical analysis of the FTIR and XRD data via the principal component analysis showed similarity trend on the effect of temperature on the carbonization products. The improved electrical property, pore development in char morphology as well as the development of near graphitization features suggest possible use as electrode materials.
DEVELOPMENT OF MOBILE LEARNING BASED ON AN INTEGRATED PREDICTION GUIDE AS A SUPPORT OF PHYSICS LEARNING IN HIGH SCHOOL ON THE TOPIC OF WAVES
Authors: Purwani Aprilia , Astuti Irnin Agustina Dwi , Dewati Maria
Published: December 2022

This research aimed to develop Android-based Mobile Learning media that is integrated with the Prediction Guide learning model using Smart Apps Creator software as research supporting high school physics learning on wave material. The research method used in this research is Research and Development (R &D) using the ADDIE development model (Analysis, Design, Development, Implementation, and Evaluation). However, due to the condition of the Covid-19 pandemic, this development research is only carried out until the development stage. The techniques used in analyzing data are descriptive analysis techniques by calculating the percentage of expert validation scores and student response tests. The analysis of this study obtained an average of 83% from media experts, 89% from material experts, and 86% from linguists. Thus, the overall average percentage of expert validation obtained an average percentage value of 86%, with very feasible information, and can be used in school. Meanwhile, the average percentage obtained from the student response test was 74% which describes a good response from the students.
Impact of Ethical Leadership on Employee Performance in the Public Sector: Does Leader-Member Exchange Matter?
Authors: Oladimeji Kazeem Adebayo , Abdulkareem Abdulrazaq Kayode , Akindele Iyiola Tomilayo , Adejumo Abdulhakeem
Published: January 2023

This study assessed the impact of ethical leadership on employee performance in the public sector using leader-member exchange as a mediator. Data for this quantitative study was gathered using a structured questionnaire administered to Nigerian federal public officials in some selected ministries. A conceptual model was drawn and put to the test using the PLS-SEM. Based on the results, all hypotheses were significant at p < 0.001. More importantly, ethical leadership positively and significantly impacts leader-member exchange and employee productivity. More so, leader-member exchange mediates the relationship between ethical leadership and employee performance. This study’s findings improve on earlier studies on ethical leadership and leader-member exchange relationships. Also, it suggests the importance of leaders’ moral behaviour and their relationship with subordinates in the workplace, by imbibing workplace ethics. This study has added to the continuing discussion on ethical leadership and its implications in the public sector in a developing nation like Nigeria.