bluuebunny/crossref_metadata_2025 huggingface dataset:
Mastitis in dairy goats from the state of Minas Gerais, Brazil: profiles of farms, risk factors and characterization of bactéria
Authors: Lima Magna C. , Souza Marina C.C. , Espeschit Isis F. , Maciel Pedro A.C.C. , Sousa Jéssica E. , Moraes Geórggio F. , Ribeiro Filho José D. , Moreira Maria A.S.
Published: November 2018

ABSTRACT: The Zona da Mata of Minas Gerais has a specialized goat milk production chain. Goat milk is superior in quality compared with milk of other domestic species, and the demand for milk and milk products for the public has increased. Data on dairy goat breeding in Minas Gerais are scarce and relatively old, and this lack of information has limited the implementation of prophylactic measures, especially for mastitis, which represents the biggest sanitary problem for dairy herds. The objective of this work was to characterize mastitis and bacteria associated with it in milking goats in the Zona da Mata of Minas Gerais. It also causes socioeconomic problems and market issues for dairy goat farming. A total of 539 lactating goats were examined and 268 individual samples (one for teat) were collected from animals positive for strip cup test and/or the California Mastitis Test (CMT). Microbiological cultures were carried out on blood agar medium and the bacteria were subjected to phenotypic, genotypic and antimicrobial susceptibility tests. The prevalence of subclinical mastitis was 28.0% and the clinical prevalence was 2.8%. Bacterial multiplication was obtained in 62% of samples. One hundred eighty seven total bacteria were identified. The most common species identified was Staphylococcus aureus (60%), followed Staphylococcus epidermidis (9.1%,), Escherichia coli (6.9%), Staphylococcus saprophyticus (5.9%) e Staphylococcus caprae (4.3%). Bacteria of the genus Staphylococcus presented a profile of resistance to antimicrobials belonging to the beta-lactam class (penicillin, ampicillin and oxacillin) in addition to tetracycline, in contrast to the other antimicrobials tested. Twelve percent of multidrug resistence (MDR) was found in five microregions. Among the bacteria with the highest prevalence of MDR, 38.5% were E. coli and 10.6% were S. aureus. The producers of the Zona da Mata of Minas Gerais are technicians who work with specialized dairy breeds and practise good management. However, some measures related to prophylaxis and control of diseases, such as vaccination, have low adherence or are not performed due to a lack of veterinary assistance. This is the first study focusing on this region, which is highly prominent in goat milk production in Brazil. It provides important information that can help in the implementation of measures for the prophylaxis and control of diseases, and for maintenance of a constant supply of products in sufficient quantities and of a quality suitable for the consumer population.
The return of relatives: processes of mobilisation and village construction among the Tupinambá of Serra do Padeiro, southern Bahia, Brazil
Authors: Alarcon Daniela Fernandes
Published: November 2018

Abstract The article examines land reclamations, actions of territorial recovery engaged in by the Tupinambá of the village of Serra do Padeiro, in southern Bahia, Brazil. It focuses on the return of relatives - i.e. the return of expropriated Indians as part of the reclamation process -, and seeks to examine the construction of the collective political subject that has engendered the reclamations, as it is engendered by them. The text presents a brief history of the process of territorialisation, indicating how the reclamations have become the group’s main form of political action. I argue that the process of land recovery is based on kinship, and is capable of activating latent ties or lead to the weakening or rupture of ties between relatives in opposing positions. I also propose that the reclamation process has extended the meaning of relative, providing nuance to the emphasis on blood and moving towards a definition of relative as those with whom you fight together.
Societies “against” and “in ” the State - from Exiwa to the Retakings: Territory, autonomy and hierarchy in the history of the indigenous peoples of Chaco-Pantanal
Authors: Ferreira Andrey Cordeiro
Published: November 2018

Abstract The purpose of this article is to conduct an exercise in historic anthropology and an anthropology of territory, based on an ethnography of the experiences of domination and resistance experienced by the indigenous peoples of Pantanal, in particular the Terena, within the processes of colonization, formation of nation states and capitalist development in South America. We will analyze experiences of indigenous autonomy against and in the state, and their dialectical territorial expression in the colonial world and in the contemporary dynamics of territorial and interethnic conflict in twenty-first century Brazil.
O RETORNO DA CENTRALIDADE DO HOSPITAL PSIQUIÁTRICO: RETROCESSOS RECENTES NA POLÍTICA DE SAÚDE MENTAL
Authors: Sousa Fernando Sérgio Pereira de , Jorge Maria Salete Bessa
Published: November 2018

Resumo Objetivou-se compreender a experiência da convivência entre os serviços substitutivos e o hospital psiquiátrico. Trata-se de um estudo com abordagem qualitativa hermenêutica. A pesquisa foi realizada no Nordeste brasileiro. Contemplou dois cenários: Centro de Atenção Psicossocial e Hospital Psiquiátrico. Contou com 14 participantes, dos quais oito trabalhadores do Centro de Atenção Psicossocial e seis trabalhadores de saúde do Hospital Psiquiátrico. Para alcançar as informações, utilizou-se a entrevista em profundidade e a observação sistemática. A coleta ocorreu no período de agosto a outubro de 2017. A análise das entrevistas ocorreu empregando-se a hermenêutica de Paul Ricoeur, por meio das seguintes etapas: transformação dos discursos em textos, leitura exaustiva, análise estrutural, compreensão do texto de forma abrangente, interpretação e análise. Os resultados denotaram que há uma convivência paradoxal entre os serviços de atenção psicossocial e o hospitalar psiquiátrico, mesmo que o serviço hospitalar não seja reconhecido e legitimado como parte da rede de saúde mental.
Diagnostic validity of different cephalometric analyses for assessment of the sagittal skeletal pattern
Authors: Ahmed Maheen , Shaikh Attiya , Fida Mubassar
Published: November 2018

Abstract Introduction: Numerous cephalometric analyses have been proposed to diagnose the sagittal discrepancy of the craniofacial structures. Objective: This study aimed at evaluating the reliability and validity of different skeletal analyses for the identification of sagittal skeletal pattern. Methods: A total of 146 subjects (males = 77; females = 69; mean age = 23.6 ± 4.6 years) were included. The ANB angle, Wits appraisal, Beta angle, AB plane angle, Downs angle of convexity and W angle were used to assess the anteroposterior skeletal pattern on lateral cephalograms. The sample was classified into Class I, II and III groups as determined by the diagnostic results of majority of the parameters. The validity and reliability of the aforementioned analyses were determined using Kappa statistics, sensitivity and positive predictive value (PPV). Results: A substantial agreement was present between ANB angle and the diagnosis made by the final group (k = 0.802). In the Class I group, Downs angle of convexity showed the highest sensitivity (0.968), whereas ANB showed the highest PPV (0.910). In the Class II group, ANB angle showed the highest sensitivity (0.928) and PPV (0.951). In the Class III group, the ANB angle, the Wits appraisal and the Beta angle showed the highest sensitivity (0.902), whereas the Downs angle of convexity and the ANB angle showed the highest PPV (1.00). Conclusion: The ANB angle was found to be the most valid and reliable indicator in all sagittal groups. Downs angle of convexity, Wits appraisal and Beta angle may be used as valid indicators to assess the Class III sagittal pattern.
Do premolar extractions necessarily result in a flat face? No, when properly indicated
Authors: Allgayer Susiane , Mezomo Maurício Barbieri
Published: November 2018

Abstract The esthetic benefits are among the main goals of orthodontic treatment; therefore, tooth extractions have been avoided as a protocol for orthodontic treatment because they may impair the facial profile. The present article discusses aspects as the magnitude and response of soft tissue profile due to changes in incisor positioning, and the effect of different sequences of premolar extraction. One case report illustrates the subject, with favorable and stable esthetic and occlusal outcomes five years after orthodontic treatment with extraction of second premolars.
Correlation between tooth size-arch length discrepancy and interradicular distances measured on CBCT and panoramic radiograph: an evaluation for miniscrew insertion
Authors: Tepedino Michele , Cornelis Marie A. , Chimenti Claudio , Cattaneo Paolo M.
Published: November 2018

Abstract Introduction: The selection of appropriate sites for miniscrew insertion is critical for clinical success. Objectives: The aim of the present study was to evaluate how interradicular spaces measured on panoramic radiograph compare with Cone-Beam Computed Tomography (CBCT), and how crowding can influence the presence of available space for miniscrew insertion, in order to define a new “safe zones” map. Methods: A total of 80 pre-treatment panoramic radiographs and 80 CBCT scans with corresponding digital models were selected from the archives of the department of Dentistry, Aarhus University. Crowding was measured on digital models, while interradicular spaces mesial to the second molars were measured on panoramic radiographs and CBCTs. For panoramic radiographs, a magnification factor was calculated using tooth widths measured on digital models. Statistical analyses were performed to investigate the correlation between the amount of crowding and the available interradicular space. Visual maps showing the amount of interradicular spaces measured were drawn. Results: The most convenient interradicular spaces are those between the second molar and the first premolar in the mandible, and between the central incisors in the maxilla. However, some spaces were revealed to be influenced by crowding. Conclusions: Calibration of panoramic radiographs is of utmost importance. Generally, panoramic radiographs underestimate the available space. Preliminary assessment of miniscrew insertion feasibility and the related selection of required radiographs can be facilitated using the new “safe zone” maps presented in this article.
Avaliação instrumentalizada do desenvolvimento infantil: nova realidade brasileira
Authors: Ferreira-Vasques Amanda Tragueta , Lamônica Dionísia Aparecida Cusin
Published: November 2018

RESUMO Objetivo Apresentar a Escala de Desenvolvimento Mental de Griffiths (EDMG), bem como sua adaptação transcultural para o Brasil. Método EDMG é um instrumento diagnóstico de avaliação do desenvolvimento infantil. O resultado de sua aplicação permite verificar se o desenvolvimento é típico ou se há diagnóstico de alteração em determinada área específica (motora grossa, pessoal-social, linguagem, motora fina-adaptativa e execução) ou do desenvolvimento global. Após contato com autores, permissão de utilização da EDMG e cumprimento dos aspectos éticos, a versão do instrumento em português europeu foi adaptada para o português brasileiro, com manutenção de equivalências semântica, idiomática, experimental e conceitual. A adaptação foi realizada por duas fonoaudiólogas, experientes em avaliação de lactentes, que realizaram o curso de capacitação para aplicar o instrumento. A versão final adaptada foi aplicada em 21 lactentes com desenvolvimento típico. Resultados Foram adaptados 39 itens, sem exclusão alguma. Todos os itens foram possíveis de serem aplicados, adequados à faixa etária alvo, sem ausência de resposta em nenhum item. Conclusão A EDMG é adaptada transculturalmente em diversos países e amplamente utilizada por realizar diagnóstico em faixa etária essencial para estimulação com a plasticidade cerebral em pleno desenvolvimento. Foi realizada a adaptação transcultural da EDMG para o Brasil, transformando o cenário brasileiro em relação à atenção a lactentes. Após normatização e verificação das medidas psicométricas, será possível, além de diagnóstico precoce, melhorar a qualidade dos atendimentos a esta população; realizar estudos transculturais e publicar em revistas internacionais com a viabilidade de a EDMG ser aceita e utilizada internacionalmente.
“Trocas nos sinais”: caracterização de processos fonológicos ocorridos durante a aquisição de Libras por pré-escolares surdos
Authors: Guimarães Cristhiane Ferreira , Campello Ana Regina e Souza
Published: November 2018

RESUMO Objetivo Descrever as características dos processos fonológicos encontrados na língua de sinais de pré-escolares surdos. Métodos Participaram da pesquisa 15 crianças surdas, com idade entre 3 e 7 anos. A coleta de dados ocorreu por meio de filmagem da aplicação do Instrumento de avaliação fonológica da língua de sinais brasileira: FONOLIBRAS, que propõe nomear, em Libras (Língua Brasileira de Sinais), 50 figuras. Foi realizada transcrição em SignWriting e os sinais de Libras com processos fonológicos foram classificados quanto ao tipo, parâmetro e mão(s) envolvida(s). Por fim, os dados receberam tratamento estatístico. Resultados Todas as crianças surdas apresentaram produção de sinais com variações linguísticas, em relação ao padrão adulto, ou seja, processos fonológicos, confirmando que é um fenômeno natural do desenvolvimento infantil também nas línguas de sinais. O tipo mais frequente foi assimilação, também estando presentes substituição, epêntese, elisão e metátese. O parâmetro configuração de mão foi o mais afetado e a ocorrência maior, na mão passiva. Conclusão De que modo os processos fonológicos fazem parte da aquisição das línguas de sinais, podendo ser naturalmente suprimidos, ou não, é um assunto que merece a atenção dos profissionais que atuam na área da surdez, de modo a aperfeiçoar o desenvolvimento da comunicação dos usuários destas línguas.
Stability and microbial toxicity of HfO2 and ZrO2 nanoparticles for photolithography
Authors: Gonzalez-Estrella Jorge , Field Jim A , Ober Christopher K , Sierra-Alvarez Reyes
Published: November 2018

Hafnium dioxide (HfO2) and zirconium dioxide (ZrO2) nanoparticles (NPs) have gained attention as components of photoresists for next-generation photolithography. Coating of these NPs with organic ligands has been shown to increase their efficiency in photolithography. This study evaluated the microbial toxicity of hafnium dioxide and zirconium dioxide NPs coated with benzoate, isobutyrate or methacrylate toward heterotrophic aerobes, methanogens and the bioluminescent bacterium Aliivibrio fischeri. The stability of NPs in the media was assessed as a function of zeta potential, particle size distribution and leaching analyses. NP dispersions were unstable in all bioassay media, resulting in particle aggregation and settling. Leaching tests showed that dissolution of the organic ligands from the NPs varied widely depending on the nanomaterial and medium considered. The NPs were harmless to aerobic heterotrophs and methanogens at high concentrations (800–1200 mg/l). In contrast, they displayed low to moderate toxicity to A. fischeri (50% inhibition at 286–1372 mg/l), with benzoate-coated NPs causing the highest inhibition. Further analyses confirmed that the inhibition observed in assays with A. fischeri should be attributed to the coated NPs rather than to the dissolved organic ligands. Overall, the NP photoresists tested in this study are unlikely to exert acute microbial toxicity at environmentally relevant concentrations (sub-parts-per-million levels).
KİŞİLERİN “SEYAHAT TIBBI” KONUSUNDAKİ BİLGİ, TUTUM VE DÜŞÜNCELERİ
Authors: AKSÜT Ayşe Gülsün , ÖNGEL Kurtuluş , SOYSAL Nazlı , GÖK BALCI Umut
Published: November 2018

Ülkelerarası seyahatin artması seyahat ile
ilişkili enfeksiyonların ortaya çıkmasına yol açmış ve “Seyahat Tıbbı” kavramı
tartışılmıştır. Aynı zamanda uluslararası seyahatin her geçen gün arttığı
bilinmektedir. Bu durum seyahat tıbbı ve
aşılamanın önemini her geçen gün arttırmaktadır. Bu nedenle birçok kişi seyahatleri boyunca veya hemen
sonrasında seyahat ilişkili bir enfeksiyon nedeniyle tıbbi yardım almak zorunda
kalmıştır.Çalışmada
toplumun seyahat tıbbı ve aşılama hakkındaki bilgi düzeyini, tutumunu ve
düşüncelerini ortaya koymak
amaçlanmıştır.

Çalışma kesitsel tanımlayıcı bir anket
çalışmasıdır. Çalışmada 1.Ocak.2014-1.Mart.2014 tarihleri arasında 3 aylık
süreçte ulaşılabilen tüm olgular hedeflendiği için örneklem seçilmeden tüm
evrene ulaşılmaya çalışılmıştır.

Çalışma sonucunda; seyahat etme oranları
eğitim ve gelir düzeyi ile artmasına rağmen, kişilerin seyahat tıbbı
konusundaki bilgi düzeyleri, tutum ve davranışlarının kendi kendilerini ve
çevresindekilerini koruyacak düzeye ulaşamadığı düşünülmektedir.
Postoperative mortality following civilian firearms injury during war: A retrospective cohort study
Authors: OKŞAR Menekşe , AKKURT Cagla , TURHANOGLU Selim
Published: November 2018

Background: This study aims to identify
factors affecting mortality following surgery for civilian firearms injuries using surgical classification as a surrogate
marker of injury severity.

Methods: This was a retrospective study of patients who underwent surgery at a
tertiary university hospital in Turkey between 2011 and 2014. All patients had
sustained firearms injury and had an American Society of Anesthesiologists
score of I-II. A grading system
defined by the Communiqué on Health Practices in Turkey
was used based on the surgery
type and anesthetic procedure to determine the severity of injury and its
relation with patient outcome (survival or death).

Results: The median duration of hospital stay of patients who were discharged post
healing was significantly longer than those who died [12 (0–559).vs 7.5 (0–468)
days, respectively]. Overall mortality
was 11.3%; however, the mortality of patients was 8.1%,
40.3%, and 40.3% in groups A2, C, and D, respectively. Healing in groups A2, C,
and D was 2.4%, 54.1% and 25.8%, respectively. Independent variables affecting the coefficient
of patient discharge status for sex, age, and
surgical groups A2, C, and D were found to be significant.

Conclusion:
There
was an association between the surgical groups and the
firearms injuries sustained by civilians. Moreover, the coefficients associated with
surgical group in our model may help predict the mortality risk in similar
populations.
Efficacy of dequalinium chloride vaginal tablets in treatment of bacterial vaginosis
Authors: Khuraseva A. B. , Reminnaya T. V.
Published: November 2018

Aim: to evaluate the efficacy and duration of the therapeutic effect of dequalinium chloride (in comparison with clindamycin) in treatment of vaginal dysbiosis. Materials and methods. A total of 73 fertile-aged women (18-35 years old) with abnormal vaginal microbiota were examined. The patients were randomized into two groups: Group 1 (main) included 37 women receiving dequalinium chloride; Group 2 (control) included 36 women under clindamycin therapy. The efficacy was assessed by analyzing patients’ complaints, by gynecological examinations, pH values of the vaginal fluid, the Amsel criteria, the microscopy results and the polymerase chain reaction (PCR). Results. Before the treatment, the Amsel criteria were positive in 36 patients (97.29%) in the main group and in 31 patients (93.93%) in the control group; all patients showed an increase in the pH values of the vaginal fluid by more than 4.5 units. The state of vaginal microbiocenosis as evaluated with RT-PCR diagnostics (Femoflor 16 analysis) identified a variety of gram-positive and gram-negative bacteria with a marked decrease in the number of Lactobacilli. During the treatment period, there were no complaints of adverse events; pH values were normal in all patients; the Femoflor 16 analysis showed a significant decrease in the amounts of pathogenic microorganisms. As assessed in 1 month after the treatment, the therapeutic effect persisted. Conclusion. The dequalinium chloride has antibacterial effect on bacterial vaginosis. The results of the study showed that dequalinium chloride had the efficacy comparable with that of clindamycin.
The health status of children born through assisted reproductive technologies: probable risks and possible complications
Authors: Pitskhelauri E. G. , Strizhakov A. N. , Timokhina E. B. , Belousova V. S. , Bogomazova I. M. , Garina A. O.
Published: November 2018

Most of the negative consequences for the health and development of children born through assisted reproductive technologies are related to health status of their mothers, i.e. infertility, age and the related metabolic, genetic and epigenetic changes affecting the quality of gametes and pregnancy. Improvement of the current techniques of in vitro fertilization, preimplantation genetic diagnosis and other preventive measures will have a favorable effect on the health status of such children.
Pregnancy management and successful delivery in a patient with Bland-White-Garland syndrome and a prosthetic mitral valve
Authors: Arslanbekova M. O. , Khizroeva D. Kh. , Samburova N. V. , Egorova E. S.
Published: November 2018

The article presents a clinical case of a pregnant woman with a prosthetic mitral valve and Bland-White-Garland syndrome. The proper pregnancy management resulted in a successful delivery of a full-term healthy child, thanks to the team approach of all specialists involved.
Iron deficiency anemia in children younger than 1 year:the search for the formula of success of outpatient management of patients
Authors: Zhukova Larisa Y , Khartchev Alexandr V , Kolobova Oksana L , Sokolova Natalya E , Tarasenko Alexandra N
Published: November 2018

172 newly diagnosed cases of iron deficiency anemia (IDA) in children younger than 1 year who were hospitalized in the Department of Hematology Saint Petersburg Сhildren Hospital No 1 in St Petersburg 2010-2015 were analyzed. Anamnesis peculiarities of IDA and outpatient care of babies, including individual prevention of iron deficiency and ferrotherapy and the causes of identified deviations from the existing patient management recommendations were clarified. Defects of sideropenia prevention found in all examined children. The fundamental error of pediatricians during ferrotherapy were the lack of verification of the nature of anemia, violation of drug dosing iron, lack of monitoring the effectiveness of treatment, failure to comply with the required duration of the courses of therapy. Mistakes made by pediatricians during the prevention, diagnosis and treatment of iron deficiency anemia are primarily a reflection of the deficit of basic knowledge of doctors on this issue. The effectiveness of the prevention of iron deficiency in infants is largely determined by the individual outpatient pediatrician, the level of his training, psychological stability and ability to engage constructively with the parents of patients. Components of success of outpatient management of patients younger than 1 year with iron deficiency are: the presence of a modern background knowledge on the issue, understanding the health and social consequences of iron deficiency for the younger generation and the desire to make a personal contribution to improving the health of children in Russia.
Follow-up Study A Children Who Are Disordered Pneumonia
Authors: Oleinik Nina A , Romanyuk Fedor P
Published: November 2018

Pneumonia is one of significant problems among infections of low airways in children. Morbidity of common-acquired pneumonia (CAP) continues to go in last year’s. Data available in the literature show, that pneumonia with empyema possibly associated with high risk of chronic obstructive pulmonary diseases, asthma and recurrent case of pneumonia in last life. Fatal pneumonia or developing chronic obstruction lung diseases occur mainly in children after severe and complicated forms of pneumonia, this information is presented in native and foreign literature. Currently pneumonia with the heavy and complicated current is a major cause of infant mortality or promotes development of a chronic obstruction lung diseases. Mortality from pneumonia is 3-19% according to different authors. The risk of respiratory diseases in the 3-6 months after pneumonia increased in children who underwent pneumonia. After complicated CAP the complete resolution of the inflammatory happens on 6-9 month. After not complicated САР forms at 10-30% of children radiological changes within 2-6 weeks were noted. In one research it is reported that the full recovery from slow resolving pneumonia at 96% of children has come on 6-8 month of the dispensary period. Some authors in the scientific works use immunomodulators and vaccinations to reduce the residual variation in the lungs and improve recovery time dramatically of pneumonia. In follow up study the important task is a identifying and elimination of risk factors for improvement of treatment and dispensary period for slow resolving pneumonia, recurrent case of pneumonia, sever pneumonia.
Psychological Rehabilitation of Patients with Physical Trauma Consequences by means of Micro-Motion Reactions Restoration Method
Authors: Petrova Elena Y , Pakhomova Maria A
Published: November 2018

Physical trauma and treatment of its consequences lies in the domain of medical specialists: traumatologists, rehabilitologists. However rehabilitation of patients with physical trauma consequences may be also successfully treated by psychologists using “unfinished tasks” expressive approach. This method utilizes micro-motion reactions differentiation principle. Micro-motion reactions restoration method (MRR) is suggested and described. It is primarily oriented at clinical psychologists and rehabilitologists. The unique nature and originality of MRR method lies in ability to trigger development of various multidirectional and contradictory impulses and reactions that had been temporarily stalled in the episode of past physical trauma. This method does not aim at relaxation of tension by means of anesthesia or other forms of isolation of strain. The treatment permits each unfinished motion impulse born during trauma to fully bloom and develop completely. As a result self-reliance and trust in spontaneity of movement is restored. MRR method is best suited for acute trauma consequences. Besides psychologists MRR method may be used by traumatologists, rehabilitologists, and also relatives of patients and parents of children patients. MRR method in the hands of relatives and parents is especially useful for rehabilitation after trauma and surgery not only for the patients but also for the relatives and parents themselves for it helps them to cope with stress of their usual helplessness during long restoration period. Bearing in mind the prospects of development of special rehabilitation units in traumatological and orthopedic departments it is obviously highly advisable to enroll psychologists mastering MRR method in these teams for it may greatly improve the potential of proper successful rehabilitation of patients with trauma consequences.
Immunohistochemical value to treat patients with chronic endometritis
Authors: Kolmyk Vera A , Nasyrov Ruslan A , Kutusheva Galiya F , Petrov Vitaliy V , Grigoryev Stepan G
Published: November 2018

One of the main causes of violations of women’s fertility is the pathology of the endometrium. Structural and functional inferiority of endometrium due to pathological inflammation, naturally leads to disruption of the implantation process and clinically infertility and prenatal losses. Finding solutions treatment of endometrial pathology exclusively relevant for the prevention of reproductive health of society. The main causes of diseases of the endometrium is inadequate hormonal regulation, acute and chronic inflammation (endometritis). Consistently high frequency CE denies membership issues to the category of banal, more kontraversii recent years postulate avoiding one-sided perception of the disease solely as a classic suppurative inflammation. For chronic endometritis is often characterized by a long asymptomatic and complexity of initial diagnosis. Important role in the development of chronic endometritis today belongs to obligate anaerobes - Bacteroides and peptostreptokokki, combined with microaerophiles and facultative anaerobic microorganisms. A special place in the development of chronic endometritis takes herpes infection. Its prevalence in all, including reproductive age is quite high. Special attention is paid to the verification of chronic endometritis immunohisto-chemical (IHC) study of the endometrium. The method can not only identify the type of infectious agent, but also to establish phase process, which has an important role to determine the treatment strategy. A special role is played by immunohistochemistry in the identification of viral etiology of chronic endometritis, as this method can reliably detect the presence of antigens to a variety of viral agents.
Expression of CD68 and Fas Ligand in Colon Mucosa of Patients with Inflammatory Bowel Disease as Prognostic Markers of Cancerogenesis
Authors: Santimov Andrey V , Kolobov Andrey V , Karev Vadim E , Kolobova Oksana L , Kostik Mikhail M , Dubko Margarita F , Kalashnikova Olga V , Masalova Vera V , Snegireva Lyudmila S , Volkova Natalia L , Khvatov Andrey A , Belogurova Margarita B , Chasnyk Vyacheslav G
Published: November 2018

As it is known, colon carcinogenesis is associated with the inflammatory bowel disease (IBD). Colorectal cancer (CRC) being observed in 5.5-13.5 % of patients with ulcerative colitis (UC) and in 0.4-0.8 % of patients with Crohn disease (CD). The gut mucosa of patients with CD, but not with UC, as well as the stroma of CRC have elevated numbers of CD68(+) macrophages. It is known also that the expression of Fas Ligand (FasL), representing another branch of immunoreactivity, in the lesions of CRC and UC but not of CD is upregulated. The fact that enterocyte apoptosis is increased in lesions of CD and lymphocytes in UC are resistant to Fas-mediated apoptosis can be the keypoint for understanding the hypothesis [17], suggesting that cells express FasL and are able to kill Fas-expressing activated lymphocytes and escape rejection by the immune system, which can be the basis for differences in association of UC and CD with CRC. The aim of this study was to evaluate the number of CD68(+) macrophages and to analyze FasL expression in colon mucosa of patients with UC, CD and CRC in order to assess its value for prognosis of CRC. Expression of CD68 and FasL was analyzed immunohistochemically in the samples of colon mucosa taken from the affected areas of 4 patients with UC, 6 patients with CD and 10 patients with CRC. In addition in 7 CRC patients the samples taken from unaffected areas were analyzed. We find average expression of FasL in both unaffected and affected areas of CRC patients was higher than in CD patients (p = 0.04, p = 0.00). Average expression of FasL in affected areas of CRC patients was higher (p = 0.02) than in UC patients and the same (p = 0.23) as in unaffected areas of CRC patients. The revealed associations support the possibility to use expression of CD68 and FasL as prognostic markers for transformation of IBD to CRC.
Constitutional features of connective tissue as a risk factor of chronic pain in adolescents
Authors: Arsentev Vadim G , Voloshina Ekaterina A , Vyutrih Elena V , Sergeev Yuriy S , Shabalov Nikolai P
Published: November 2018

A total of 504 male adolescents aged 14-18, cadet schools students were examined to identify primary head pain and functional abdominal pain. A 4-stage-blind clinical laboratory and case-control psychological examination, in which are formed two groups: basic - 90 boys with primary head pain and functional abdominal pain, and 93 healthy children (control group). Total number of teens with headaches was 76 (48 isolated headaches and 28 - headaches in conjunction with abdominal pain). The number of cadets with abdominal pain was 42, 14 was manifested monosemeiotic and 28 - in conjunction with headaches. Complex research revealed pathogenetic common primary headaches and functional abdominal pain, to identify risk factors for their development. The analysis of the results of complex examination adolescents univariate statistics significant association features of the connective tissue with the presence of primary headache, especially in combination with functional abdominal pain. Obtained significant differences in many biological, psychological and social characteristics. This fact indicates eligibility review genesis of functional disorders with painful symptoms in adolescents from the perspective of the biopsychosocial model. The present results indicate the importance of the state of the connective tissue as an essential component of the formation of predisposition to chronic pain. Other predictors of pain were advancing sexual development, emotional instability, additional sports classes.
Assessment of vegetative regulation in young people
Authors: Reeva Svetlana V
Published: November 2018

Purpose. To estimate the prevalence and type of disturbance of the vegetative regulation in young adults and to compare the frequency of autonomic dysfunction with the severity of the phenotypic manifestations of inherited connective tissue disorders (ICTD).Methods. 350 young adults were examined in a clinical study (collection of complaints), and with help the special “questionnaire for detection of signs of autonomic dysfunction”. At 61 young men was performed Holter ECG monitoring and cardiovascular tests D. Ewing. Results. The average number of complaints in the group of 317 healthy students was 6.5 ± 1.7. Almost all of the complaints have found significantly more frequent in girls. Examination with help special questioning for detection of autonomic dysfunction (AD) revealed AD a bit more often in girls than in boys (79 % and 64 %, respectively). Due to gender differences, further study carried out in a group of 61 young men. Нeart rate variability and autonomic test results in the groups of young men with and without AD according to the questionnaire did not reveal significant differences. At the same time in 30 % of young men without AD according to questionnaire have found an abnormal result in the active orthostatic test (AOT). Estimation of anthropometric indices and clinical features of inherited connective tissue disorders revealed that young men with AD based on the results of the questionnaire have more of skeletal and skin symptoms than that of young men without AD. The involvement of the skeletal system was present significantly frequently in young men with abnormal result AOP than that of young men with a normal result of AOP (90% and 55% respectively, p < 0,001).Conclusion. Our study showed that AD present in the majority of young people. However, most often both subjective and objective signs of autonomic disorders common in young people with signs ICTD.
Contemporary aspects of pathogenetically substantiated therapy of adenomyosis
Authors: Arutyunyan Arutyun F , Gaydukov Sergey N , Kustarov Vitaly N
Published: November 2018

The purpose of our study was to assess the effectiveness of the use of drugs containing indole-3-carbinol and epigallocatechin-3 gallate in combination with effective natural methods (TES-therapy and hirudotherapy) depending on the degree of morphological adenomyosis. The study involved 205 women with diffuse adenomyosis. Based on survey data from 205 women surveyed in 67 verified adenomyosis first degree (Group 1), 79 - second degree adenomyosis (group 2), and 59 - third degree adenomyosis (group 3). Doppler results showed that in patients with adenomyosis first degree nizkorezistentny uterine blood flow was observed. Improvement of clinical symptoms of the disease, increasing the numerical values of R & D in the uterine arteries at the first degree adenomyosis indicates pathogenic effects of the proposed treatment. At the same time in patients with adenomyosis II-III degree was observed with highly bloodstream, indicating the deterioration of blood flow in the uterine vascular basin, as evidenced by some of hemostasis. Thus, studies have provided credible evidence pathogenesis mediated relations between the characteristics of the circulation of the uterus, the processes of neoangiogenesis, proliferation in the myometrium and the extent of spread of the disease, which will choose the appropriate methods of conservative treatment. Using drugs and Indinol epigallat affecting the basic pathogenetic mechanisms of adenomyosis, opens a new direction in the treatment of this disease, and effective natural methods - new opportunities in the treatment of adenomyosis.
Medical Illiteracy of Parents and its Impact on Children’s Health
Authors: Ostrovskiy Igor M , Prokhorov Evgeniy V , Narizhnyy Maksim Ju
Published: November 2018

Purpose —to find out the impact of the medical illiteracy of parents on children’s health.Materials and Methods:the research method —a questionnaire. Questionnaires distributed among parents of children of all ages —between one year old and seventeen. Analyzed 564 questionnaires. It was indicated the position witnessing about the medical illiteracy of parents. Determined medical illiteracy of parents group and detected medical illiteracy of parents coefficient.Data.It was found that in the group of medical illiteracy of parents complaints about the health of children was significantly more than in the group without an medical illiteracy of parents and in the total sample. The incidence of bronchitis, pneumonia, tonsillitis (chronic tonsillitis) and children’s infections in the group with the medical illiteracy of parents significantly more than in the whole sample and the group without medical illiteracy of parents. Children from group with medical illiteracy of parents significantly more often complain and consist at a dispensary. In the subgroup of medical illiteracy of parents with a high coefficient obtained even higher morbidity rates. Communication between medical illiteracy of parents and the pathology of pregnancy, the incidence of ARVI and the frequency of antibiotics absent.Conclusions.The revealed regularities allow to predict the possible violations in the health status of children with medical illiteracy of parents, depending on the coefficient.
Echocardiography in the differential diagnosis of patent ductus arteriosus in children
Authors: Prijma Nikolaj F , Popov Valeriy V , Ivanov Dmitry O
Published: November 2018

The aim of this study was to attempt to carry out the analysis and interpretation of the clinical course of the disease in children with documented congenital heart disease - patent ductus arteriosus. To compare the data with the size of auscultation of patent ductus arteriosus and the direction to be bypassed through the blood stream, obtained during routine echocardiography. Using echocardiography to examine abnormal diastolic flow in the pulmonary artery trunk, simulating patent ductus arteriosus. Echocardiography was performed in 2173 a child under the age of 1 day of life to 18 years. Of these outpatient echocardiographic study was performed in 1503 children permanently surveyed 670 children. Patent ductus arteriosus was diagnosed in 66 children, which made up 3% of the total surveyed. Of these, 48 girls and 18 boys (ratio 2.6 : 1). In the classification of the identified patent ductus arteriosus, we have a new form of it has been identified and proposed - a continuously recurrent, which met in 5 children. When comparing the data auscultation with different kinds of patent ductus arteriosus was found that the classic “machine” systolic-diastolic murmur, accompanied by only 20% of defects, 60% of the children to listen to a systolic murmur in the 2-3 intercostal space on the left in the sternum, in some cases accompanied by focus 2nd tone of the pulmonary artery. The remaining 20% of the children surveyed, a significant auscultatory pattern generally absent. The paper presents the criteria for echocardiographic diagnosis between patent ductus arteriosus, and pulmonary and aorto-coronary-pulmonary fistulas, and fistulas. It is shown that when rendering the bifurcation of the pulmonary artery from the left parasternal short-axis access, deficiency or complete absence of tissue in the projection of aorto-pulmonary ligaments (ligamentum arteriosum), may indicate the presence of a patent ductus arteriosus.
Manifestation of cardiomyopathy in patients with Marfan syndrome and marfanoid habitus
Authors: Luneva Ekaterina B , Malev Eduard G , Korshunova Alexandra L , Reeva Svetlana V , Timofeev Evgeniy V , Zemtsovsky Eduard V
Published: November 2018

Marfan syndrome is a common genetically determined pathology of connective tissue. It was showed a reduction in systolic and diastolic left ventricular function in patients with Marfan syndrome, as well as the increase in left ventricle size, regardless of previous surgical intervention. Now in literature use the term “cardiomyopathy in Marfan syndrome,” denoting changes of the left ventricular function, in the absence of hemodynamic reasons for its deterioration. In this paper we evaluated the morphological and functional characteristics of the left ventricle, not only in patients with Marfan syndrome, but also in patients with marfanoid habitus.Materials and methods. The study included 98 people, 8 of them – patients with Marfan syndrome, 24 examinees with marfanoid habitus and 66 healthy examinees – control group. To all patients entered into the study, echocardiography was performed. Additionally global and local deformation of the myocardium using techniques speckle tracking was assessed.Resultssignificant difference circumferental deformation parameters of the anterior and lateral walls of the left ventricle and its statistically significant reduction in the group with marfanoid habitus was obtained.Conclusionsimpaired regional contractility may be the first sign of cardiomyopathy in patients with Marfan syndrome and in such a dysplastic phenotype as marfanoid habitus that is likely associated with hereditary disorders of the structure and function of connective tissue in various states of dysplastic phenotipes.
Жилищные исследования в Российской Федерации: состояние, цели, институты
Authors: Гареев Ильнур Фаилович
Published: November 2018

Состояние жилищных исследований в России в сравнении с западными странами мира не отличается системностью и широким разнообразием. В нашей стране малое количество заказчиков и профессиональных участников, заинтересованных в результатах качественных жилищных исследований. При этом и академическое сообщество не характеризуется единым движением, что отражается рваным ритмом исследований, отсутствием глобальных стратегических задач и последовательности. В связи с этим нами была поставлена цель по анализу состояния жилищных исследований в России, выявлению институтов, занимающихся исследованиями в данной области и разработке предложений, направленных на становление специализированной научно-практической информационной системы, способной обеспечить организовать жилищные исследования. По результатам исследования нами выявлен круг ведущих участников рынка недвижимости, осуществляющих жилищные исследования и заинтересованных в их результатах. Разработана концепция информационной системы, способной обеспечить накопление и приращение знаний о жилищной сфере. Сформулированы новые метрики, позволяющие выявлять наиболее сильных исследователей и журналы, специализирующиеся на жилищной тематике. Представленные выводы адресованы академическим исследователям, профессиональному сообществу и органам государственного управления как потенциальным заказчикам жилищных исследований.
Structural analysis of the Aβ(15-40) amyloid fibril based on hydrophobicity distribution
Authors: Dułak Dawid , Banach Mateusz , Gadzała Malgorzata , Konieczny Leszek , Roterman Irena
Published: November 2018

The Aβ42 amyloid is the causative factor behind various neurodegenerative processes. It forms elongated fibrils which cause structural devastation in brain tissue. The structure of an amyloid seems to be a contradiction of protein folding principles. Our work focuses on the Aβ(15-40) amyloid containing the D23N mutation (also known as the “Iowa mutation”), upon which an in silico experiment is based. Models generated using I-Tasser software as well as the fuzzy oil drop model – regarded as alternatives to the amyloid conformation – are compared in terms of their respective distributions of hydrophobicity (i.e. the existence of a hydrophobic core). In this process, fuzzy oil drop model parameters are applied in assessing the propensity of selected fragments for undergoing amyloid transformation.
Control of Contribution of Cracking and Intermolecular Hydrogen Transfer in Cracking of Gasoline Fractions in Fixed and Circulating Catalyst Bed Reactors
Authors: Potapenko O. V. , Lutchenko A. S. , Doronin V. P. , Sorokina T. P. , Plekhanov M. A. , Gurievskikh S. Yu. , Khrapov D. V.
Published: November 2018

The studies were focused on the influence of key parameters (temperature, pressure, dilution of the reaction medium with an inert gas) of catalytic processes (cracking of vacuum gasoil, hydrogen-free upgrading and cracking of gasoline fractions) on the ratio of selectivities to cracking and intermolecular hydrogen transfer. Controlling the ratio of these reactions allows the required products to be obtained on the feedstock processing. Lengthening of the feedstock-catalyst contact time, a decrease in the proportion of the diluting inert gas, and the pressure rise provides an increase in the selectivity to hydrogen transfer. Fixed and circulating catalyst bed setups were used for the experiments. Transformations of the feedstock containing deuterated compounds were studied.
Application of Thermostable Lipolytic Bacterial Enzymes for Modern Biotechnological Processes: Review
Authors: Samoilova Yu. V. , Sorokina K. N. , Piligaev A. V. , Parmon V. N.
Published: November 2018

In the review paper, the modern investigations on the application of thermostable lipolytic bacterial enzymes for biotechnology are discussed, the properties of these enzymes discussed including their activity and functional stability at various temperatures, pH in organic solvents, as well as the substrate specificity and activity in the presence of various chemical compounds. The paper contains data on the development of recombinant producers of lipolytic bacterial enzymes and on approaches to improving their productivity. The application of the bacterial lipases for biotechnological processes of synthesis of biofuel, various chemicals and detergents, for food industry and wastewater treatment is considered.
Survey of the status of iron and sclerostin in major Thalassemia Patients
Authors: Moinzadeh Leila , Reza Keramati Mohammad , Taha Jalali Mohammad , Keikhaei Bejan , Saki Najmaldin , Saki Malehi Amal , Mohammadi Zahra , Mirdoraghi Mohammad , Fatemeh Shams Seyyede , Hadi Sadeghian Mohammad
Published: November 2018

Background and Aims: Thalassemia is one the most prevalent genetic anemia in the world; homozygote patients usually suffer from severe disturbances. Osteopenia and osteoporosis are of various types of thalassemia complications which are increase in rate in patients with iron overload conditions. Sclerostin is a protein which enhances bone loss by inhibiting osteoblasts. The aim of this study was to measure sclerostin protein and its association with iron overload in major thalassemia patients.
Materials and Methods: Forty patients with major beta-Thalassemia and 40 healthy control individuals were includedin the study; Sclerostin protein and ferritin were evaluated using ELISA method.
Results: Mean sclerostin protein was 100.7 pg/ml, in the case group; it was 143.1 pg/ml in the control group.There was a significant differences between sclerostin protein in case and control groups (p= 0.015). The association of sclerostin and ferritin was not significant in the case group (p= 0.7), while  it was meaningful in the control individuals (p= 0.037).
Conclusion: Our findings suggest that sclerostin protein can play an important role in the pathogenesis of osteoporosis.