bluuebunny/crossref_metadata_2025 huggingface dataset:
A Proportional Sentiment Analysis of MOOCs Course Reviews Using Supervised Learning Algorithms
Authors: Singh Anuj Kumar , Kumar Sandeep , Bhushan Shashi , Kumar Pramod , Vashishtha Arun
Published: November 2021

When anyone is looking to enroll for a freely available online course so the first and famous name comes in front of the searcher is MOOC courses. So here in this article our focus is to collect the comments by enrolled users for the specified MOOC course and apply sentiment analysis over that data. The significance of our article is to introduce a proficient sentiment analysis algorithm with high perceptive execution in MOOC courses, by seeking after the standards of gathering various supervised learning methods where the performance of various supervised machine learning algorithms in performing sentiment analysis of MOOC data. Some research questions have been addressed on sentiment analysis of MOOC data. For the assessment task, we have investigated a large no of MOOC courses, with the different Supervised Learning methods and calculated accuracy of the data by using parameters such as Precision, Recall and F1 Score. From the results we can conclude that when the bigram model was applied to the logistic regression, the Multilayer Perceptron (MLP) overcomes the accuracy by other algorithms as SVM, Naive Bayes and achieved an accuracy of 92.44 percent. To determine the sentiment polarity of a sentence, the suggested method use term frequency (No of Positive, Negative terms in the text) to calculate the sentiment polarity of the text. We use a logistic regression Function to predict the sentiment classification accuracy of positive and negative comments from the data.
Ситуационные задачи на уроках географии
Authors: Джумагалиева К.М. , Булдакова Н.Б. Н.Б.
Published: November 2021

В статье автор подчеркивает актуальность применения активных методов обучения в учебно-воспитательный процесс на примере ситуационных задач, так как они способствуют развитию у учащихся умений ориентированию в ситуации и применению знаний на практике. Представлены разные авторские подходы к формулировке понятия «ситуационная задача». Ситуационные задачи составляются на основе возрастных особенностей учащихся. Проведен эксперимент по внедрению ситуационных задач в учебный процесс, с целью выявления уровня практических умений учащихся до и после применения в учебновоспитательном процессе по географии ситуационных задач. При использовании ситуационных задач на уроках географии у обучающихся формируются географическое мышление, умения ориентироваться в разнообразной информации, быстро и самостоятельно находить информацию, необходимую для решения задач. В статье показаны примеры ситуационных задач для учащихся 9-11 классов при изучении нового материала.
К вопросу об инклюзивном образовании в изучении иностранного языка в рамках технического вуза
Authors: Куцобина Н.В. , Пугачёва Л.М. Л.М.
Published: November 2021

В данной статье рассматриваются вопросы формирования интеллектуальных компетенций студентов с ограниченными возможностями в рамках технического вуза.
Проблемы дошкольного образования
Authors: Маренина Т.А.
Published: November 2021

В статье исследуются глобальные проблемы детских садов. В результате исследования сформулированы области, на которые необходимо обратить внимание и в дальнейшем найти оптимальные пути решения.
Развитие непрерывного образования современного педагога высшего образования
Authors: Островская И.Э.
Published: November 2021

Новые качества жизни становятся условиями развития образования, требуют обновления целей и предъявляют к образованию новоявленные притязания. Одним из таких притязаний является способность человека перманентно учиться – искать и находить знания, применять их на практике, не удовлетворяться достигнутым, постоянно обновлять, приводить в систему и ревизовать собственные знания. Данная способность становится способом адаптации и защиты от постоянно возникающих угроз и одновременно механизмом достижения собственного благополучия и относительной стабильности. Образование как смысл и ценность, как социальный институт и политика, как образ жизни приобретает актуальную характеристику «непрерывное». В настоящей статье автором проведен научный анализ и критическое осмысление проблемы развития непрерывного образования современного педагога высшего образования.
Двуязычие как фактор транслирования педагогических знаний в национальнорегиональной образовательной среде (на материале Республики Ингушетия)
Authors: Султыгова Л.М. , Кузнецова Н.В.
Published: November 2021

Предлагаемая широкой педагогической общественности статья посвящена проблеме двуязычия в ракурсе транслирования педагогического знания в национально-региональной среде. Материалом для изучения такой среды послужило образование в Республике Ингушетия. В статье рассмотрена феноменология двуязычия вообще, ингушско-русского, в частности. Выявлены его педагогические особенности. Произведена оценка обучения национальному и русскому языкам в республике.
Формирование высокого уровня двигательных способностей на секционных занятиях по баскетболу в общеобразовательном учреждении
Authors: Феуерман В.В. , Сейдаметов Р.Н.
Published: November 2021

Рассмотрен вопрос крайней важности – проведение регулярных секционных занятий, в рамках физкультурно-спортивного направления дополнительного образования, с обучающимися старшего школьного возраста общеобразовательных учреждений. Для формирования высокого уровня технического мастерства обучающихся старшего школьного возраста, занимающихся баскетболом, как показал, проведённый педагогический эксперимент, основным фактором является поддержание у последних должного уровня физической подготовленности.
Методика духовно-нравственного воспитания военнослужащих-контрактников в армейской среде
Authors: Шидов А.З.
Published: November 2021

В статье автор затрагивает актуальную в современном российском обществе проблему духовно-нравственного воспитания личности в условиях прохождения военной службы по контракту. В рамках исследования выявляется противоречие, между сложившимся традиционным подходом к воспитанию военнослужащих-контрактников, как «вчерашних призывников» и необходимостью поиска новых подходов к воспитанию данной категории военнослужащих, учитывающих их психолого-педагогические особенности и современные условия. Для разрешения данного противоречия автором предлагается разработка методики духовно-нравственного воспитания военнослужащих-контрактников, основанной на последовательном формировании у них духовно-нравственных качеств на когнитивном, деятельностном и рефлексивном уровне. Полученные результаты могут лечь в основу разработки программ духовно-нравственного воспитания военнослужащих в современных воинских коллективах.
Анализ показателей социально-психологической адаптации специалистов со стажем профессиональной деятельности до 1 года на предприятии пищевой промышленности
Authors: Нелюбина Е.Г.
Published: November 2021

В статье представлен результат по определению показателей социальнопсихологической адаптации специалистов со стажем профессиональной деятельности до 1 года на предприятии ООО «Шик» города Самары, подробно описана характеристика полученных результатов.
Факторы, влияющие на психику человека вследствие пандемии
Authors: Поджидаев А.А.
Published: November 2021

В статье приводятся факторы, влияющие на психику человека вследствие пандемии. Поясняется, почему пандемия стала причиной страха и тревоги для большей части населения планеты и оказала влияние на психическое здоровье миллионов людей - потеря близких, изоляция, экономические потрясения и неуверенность в завтрашнем дне. Сложившаяся ситуация стала тяжелым испытанием для многих жителей планеты. Психологическое утомление и истощение, бессонница, депрессия и страх, а также суицидальные настроения могут возникать на фоне глобальных потрясений. Согласно исследованиям, подобные настроения были нередки и во время эпидемии атипичной пневмонии в 2002 году, и во время пандемии испанского гриппа в 18-20 годах прошлого столетия. Пандемия коронавируса не исключение.
Особенности смысложизненных ориентаций как детерминанты процесса самоопределения в подростковом возрасте
Authors: Хасабова К.А.
Published: November 2021

В статье освещена проблема детерминант процесса самоопределения в подростковом возрасте. Автор дал психологическую характеристику явлению самоопределения, представлен обзор теоретических подходов к его изучению. Исследованы особенности формирования смысложизненных ориентаций в подростковом возрасте, которые оказывают влияние на самоопределение личности.
Роль музыки периода Великой Отечественной войны в духовной жизни России
Authors: Трегулова Н.П.
Published: November 2021

Автор статьи рассматривает песенное наследие Великой Отечественной войны как феномен отечественной музыкальной культуры XX века. Музыкальные произведения, посвященные тяжелой кровопролитной войне, суровым испытаниям и воле к победе, служили духовной опорой людей в годы Великой Отечественной войны. Они вдохновляли на подвиг ради своей Родины, обращались к патриотическим чувствам, призывали к полной самоотдаче в борьбе за свободу.
Statistična poslovna analiza: Gradiva za seminarske in laboratorijske vaje
Authors: Tominc Polona , Rožman Maja
Published: November 2021

Gradivo Statistična poslovna analiza vsebuje naslednje vsebinske sklope: opisna statistika in vzorčni pristop, preizkušanje domnev o statistično značilnih razlikah med povprečnimi vrednostmi spremenljivke v več vzorcih ter regresijska analiza. Študenti v okviru predmeta na katerega se nanaša gradivo, spoznajo uporabnost statističnih metod pri reševanju poslovnih problemov ter utrdijo in nadgradijo teoretično znanje na področju statističnih tehnik in metod, ki omogočajo spremeniti različne podatke v uporabne informacije za poslovno odločanje. Študenti usvojijo analitičen matematično statističen pristop k preučevanju poslovnih problemov, ki se sestoji iz naslednjih korakov: formulacija problema na statističen način, izbira ustrezne statistične metode, reševanje problema in interpretacija rezultatov v smislu možnih rešitev problema. V tej zbirki nalog opisujemo nekatere statistične kvantitativne metode, ki predstavljajo orodje v poslovnih raziskavah, pri čemer uporabljamo programsko orodje IBM SPSS.
Nano- and micromorphological evidences of the colloidal structure of ring silicate crystal inclusions
Authors:   Institute of Geology FRC Komi SC UB RAS, Piskunova N. N. , Kryazhev A. A.
Published: November 2021

The substance released naturally during mechanical opening of growth inclusions of aquamarine, beryl and tourmaline crystals (Transbaikalia, Russia) has been studied by scanning atomic force microscopy (AFM) and electron microscopy (SEM). The liquid part of the substance of the inclusions is a sufficiently concentrated colloidal sol-gel-silicate system. The diffused silicate colloid forms a film, poorly removable from the chip surface, which is reliably detected by AFM and transformed under prolonged exposure to an electron beam into a foam-glass. The latter fact can be used to create sub-micron textures that are stable under normal conditions by electron-beam lithography. The study of quartz and phenacite (Ural, Russia) did not reveal such films. In contrast to aquamarine, the inner walls of cavities of quartz and phenacite inclusions, according to AFM data, are covered with growth hills, grown by the dislocation mechanism. This indicates a relatively low degree of polymerization of the silicate component in the initial hydrothermal mother liquor for quartz and phenacite compared to the degree of polymerization in the mineral-forming media of ring silicate crystals.
Midiatização da saúde: as perspectivas de uma vida saudável no ecossistema jornalístico
Authors: Mascarelo da Silva Thalita , Gentilli Victor Israel
Published: November 2021

Este trabalho apresenta um breve panorama sobre a relação dos meios de comunicação com assuntos da saúde a partir do protagonismo das fontes de informação especializadas, suas particularidades e discussões. Portanto, o nosso objetivo é de compreender o papel da informação na construção de conceitos em saúde no atual contexto de midiatização social. Dessa forma, o percurso metodológico vislumbrou reunir vertentes de estudo sobre o tema midiatização da saúde e problematizar a lógica da prática da construção de perspectivas sobre vida saudável, a partir das fontes de informação no ecossistema jornalístico. Os resultados demonstraram que as novas mediações criam relações e interações complexas entre a utilização de conceitos nas novas mídias sociais pelos profissionais de saúde em suas dinâmicas com o público em geral.
Education as a subject of philosophy
Authors:   Namangan Engineerng Technological Institute, Mirzakhmedov A.M.
Published: November 2021

Discussed is upbringing as a socio-cultural characteristic of social experience, which makes it possible to form an idea of ​​upbringing as a necessity for social progress in philosophical thought. A complex of philosophical and pedagogical methods is used: analysis, synthesis, comparison, discourse analysis of educational programs, secondary analysis of the results of sociological research. It is determined that modern pedagogy is characterized by a crisis of the educational process, which has arisen with an urgent need for a philosophical understanding of the problem of education. The purpose of this work is to analyze the specifics of a philosophical approach to the phenomenon of education as a process of socio-philosophical research. In this regard, a need arose to study the essence of the phenomenon of education in the context of global information technology. According to the authors, the philosophy of upbringing is the most important factor in the interdisciplinary study of the problems of upbringing for the improvement of society. n arguing this issue, the authors are based on the pedagogical concepts of famous philosophers who determined the development of pedagogy of the last century. Thus, the authors propose to include in the curriculum the course “Philosophy of Education” that exists in the universities of the CIS. The authors of the articles identified the priorities of the effectiveness of higher and secondary specialized education in interdisciplinary research of the problem of education.
Distant professional training of additional education teachers at Pedagogical University
Authors:   Altai State Pedagogical University, Shatalova E.A.
Published: November 2021

Examined are possibilities of an innovative approach to improving the qualifications of teachers of additional education on the example of the Altai State Pedagogical University. The advanced training program for teachers of additional education “Professional activity of a teacher of additional education in modern socio-cultural conditions” contributes to the development of the competencies necessary for the professional activity of a teacher of additional education in accordance with the requirements of the professional standard “Teacher of additional education for children and adults”. The innovative content of distance education for this category of teachers is dictated by changes in the regulatory framework of pedagogical activity, namely, the approval of the 2018 “Professional standard for teachers of additional education for children and adults”, new requirements of innovative projects of the Development Program of an educational institution. The remote form of organizing advanced training courses for teachers of additional education at the Altai State Pedagogical University serves as an experimental platform for further designing retraining programs for teachers of additional education and contributes to obtaining high-quality advanced training for specialists from the most remote parts of the region without interruption from work. The presented program of distance courses for advanced training will have positive results in terms of promoting IR technologies in the educational space of the Altai Territory.
A Patient With Multiple Carbapenemase Producers Including an Unusual Citrobacter sedlakii Hosting an IncC blaNDM-1- and armA-carrying Plasmid
Authors: Moser Aline , Keller Peter , Campos-Madueno Edgar I. , Poirel Laurent , Nordmann Patrice , Endimiani Andrea
Published: November 2021

Background. Patients colonized with multiple species of carbapenemase-producing Enterobacterales (CPE) are increasingly observed. This phenomenon can be due to the high local prevalence of these pathogens, the presence of important host risk factors, and the great genetic promiscuity of some carbapenemase genes.
Methods. We analyzed 4 CPE (Escherichia coli, Klebsiella pneumoniae, Providencia stuartii, Citrobacter sedlakii), 1 extended-spectrum cephalosporin-resistant K. pneumoniae (ESC-R-Kp), and 1 carbapenemase-producing Acinetobacter baumannii simultaneously isolated from a patient transferred from Macedonia. Susceptibility tests were performed using a microdilution MIC system. The complete genome sequences were obtained by using both short-read and long-read whole-genome sequencing technologies.
Results. All CPE presented high-level resistance to all aminoglycosides due to the expression of the armA 16S rRNA methylase. In C. sedlakii and E. coli (ST69), both the carbapenemase blaNDM-1 and armA genes were located on an identical IncC plasmid of type 1a. The K. pneumoniae (ST268) and P. stuartii carried chromosomal blaNDM-1 and blaOXA-48, respectively, while the ESC-R-Kp (ST395) harbored a plasmid-located blaCTX-M-15. In the latter 3 isolates, armA-harboring IncC plasmids similar to plasmids found in C. sedlakii and E. coli were also detected. The A. baumannii strain possessed the blaOXA-40 carbapenemase gene.
Conclusions. The characterization of the genetic organization of IncC-type plasmids harbored by 3 different species from the same patient offered insights into the evolution of these broad- host-range plasmids. Moreover, we characterized here the first complete genome sequence of a carbapenemase-producing C. sedlakii strain, providing a reference for future studies on this rarely reported species.
Modulation of hemostasis by inhibiting enzymes with the extract of Averrhoa carambola leaves
Authors: Oliveira Daniela Aparecida , Cesar Pedro Henrique Souza , Trento Marcus Vinicius Cardoso , Braga Mariana Aparecida , Marcussi Silvana
Published: November 2021

Herbal medicines represent an advantageous alternative for the prevention and treatment of several diseases when compared to allopathic medicines. Averrhoa carambola (Oxalidaceae) is a plant rich in phenolic compounds and popularly known for its medicinal properties such as anti-inflammatory, antioxidant, and hypoglycemic. Different enzymes of the human organism participate in physiological processes which involve hemostasis, inflammation, and formation of new tissue. These enzymes are highlighted as pharmaceutical targets for the treatment of numerous pathologies. The present work evaluated the aqueous and ethanolic extracts from A. carambola leaves on phospholipase, hemolytic, caseinolytic, thrombolytic, coagulant, and fibrinogenolytic activities induced by phospholipases A2 and proteases. Phenolic compounds and total flavonoids were quantified in the aqueous and ethanolic extracts of the leaves of Averrhoa carambola. These extracts were evaluated, in vitro, on phospholipase, proteolytic, hemolytic, thrombolytic and fibrinogenolytic activities induced by snake venoms. The results confirm the pharmacological potential of A. carambola since the extracts were able to modulate all evaluated activities related to hemostasis through inhibitions or potentiation of the enzymatic activities (phospholipases A2 and proteases). The constituents of A. carambola may act interfering in processes such as coagulation, thrombus dissolution, and fibrinogenolysis.
Factors Associated With Chronic Kidney Disease in Patients With Type 2 Diabetes in Bangladesh
Authors: Islam Sheikh Mohammed Shariful , Salehin Masudus , Zaman Sojib Bin , Tansi Tania , Gupta Rajat Das , Barua Lingkan , Banik Palash C , Uddin Riaz
Published: November 2021

Diabetes and chronic kidney disease (CKD) are a major public health burden in low-and-middle-income countries. This study aimed to explore factors associated with CKD in patients with type 2 diabetes (T2D) in Bangladesh. A cross-sectional study was conducted among 315 adults with T2D presenting at the outpatient department of Bangladesh Institute of Health Sciences (BIHS) hospital between July 2013 to December 2013. CKD was diagnosed based on estimated Glomerular Filtration Rate using the ‘Modification of Diet in Renal Disease’ equations and presence of albuminuria estimated by the albumin-to-creatinine ratio. Multivariate logistic regression analysis was used to determine the factors associated with CKD. The overall prevalence of CKD among patients with T2D was 21.3%. In the unadjusted model Factors associated with CKD were: aged 40-49 years (OR: 5.7, 95% CI: 1.3-25.4), age 50-59 years (7.0, 1.6-39), age ≥60 years (7.6, 1.7-34); being female (2.2, 1.2-3.8), hypertensive (1.9, 1.1-3.5) and household income between 128.2-256.4 US$ (2.9, 1.0-8.2) compared with income ≤128.2$. However, after adjustment of other covariates, only duration of hypertension and household income (128.2-256.4 US$) remained statistically significant. There is a need to implement policies and programs for early detection and management of hypertension and CKD in T2D patients in Bangladesh.
Monte Carlo Radiative Transfer Simulation to Analyze the Spectral Index for Remote Detection of Oil Dispersed in the Southern Baltic Sea Seawater Column: The Role of Water Surface State
Authors: Otremba Zbigniew , Piskozub Jacek
Published: November 2021

The presented results of simulations take into account the optical parameters of the selected sea region (from literature data on the southern Baltic Sea) and two optically extreme types of crude oil (from historical data) which exist in the form of a highly diluted oil-in-water emulsion (10 ppm). The spectral index was analyzed based on the results of modelling the radiance reflectance distribution for almost an entire hemisphere of the sky (zenith angle from 0 to 80o). The spectral index was selected and is universal for all optically different types of oil (wavelengths 650 and 412 nm). The possibility of detecting pollution in the conditions of the wavy sea surface (as a result of wind of up to 10 m/s) was studied. It has been also shown that if the viewing direction is close to a direction perpendicular to the sea surface, observations aimed at determining the spectral index are less effective than observation under the zenith angle of incidence of sunlight for all azimuths excluding the direction of sunlight specular reflection.
Autologous Gradient Formation Under Differential Interstitial Fluid Flow Environments
Authors: Stine Caleb , Munson Jennifer
Published: November 2021

Fluid flow and chemokine gradients play a large part in not only regulating homeostatic processes in the brain, but also in pathologic conditions by directing cell migration. Tumor cells in particular are superior at invading into the brain resulting in tumor recurrence. One mechanism that governs cellular invasion is autologous chemotaxis, whereby pericellular chemokine gradients form due to interstitial fluid flow (IFF) leading cells to migrate up the gradient. Glioma cells have been shown to specifically use CXCL12 to increase their invasion under heightened interstitial flow. Computational modeling of this gradient offers better insight into the extent of its development around single cells, yet very few conditions have been modelled. In this paper, a computational model is developed to investigate how a CXCL12 gradient may form around a tumor cell and what conditions are necessary to affect its formation. Through finite element analysis using COMSOL and coupled convection-diffusion/mass transport equations, we show that velocity (IFF magnitude) has the largest parametric effect on gradient formation, multidirectional fluid flow causes gradient formation in the direction of the resultant which is governed by IFF magnitude, common treatments and flow patterns have a spatiotemporal effect on pericellular gradients, exogenous background concentrations can abrogate the autologous effect depending on how close the cell is to the source, that there is a minimal distance away from the tumor border required for a single cell to establish an autologous gradient, and finally that the development of a gradient formation is highly dependent on specific cell morphology.
Pandemic-induced Reductions on Swim Training Volume and Performance in Collegiate Swimmers
Authors: Martinez Perez Gloria , VanSumeren Matthew , Brown Michael , Hew-Butler Tamara
Published: November 2021

The COVID-19 pandemic caused significant training disruptions during the 2020-21 season due to lockdowns, quarantines, and strict adherence to pandemic protocols. The main purpose of this study was to determine how pandemic training restrictions affected training volume and performance in one collegiate swim team. Cumulative training volume data, across a 28-week season, were compared between a pandemic (2020-2021) versus non-pandemic (2019-2020) season. Swimmers were categorized into three groups (Sprinters, Mid-Distance, and Long-Distance) based on training group. Performance times in 25 swimmers who competed in Regional Championships, during both the non-pandemic and pandemic year, were compared via 1-way ANOVA. 26 male and 22 female swimmers commenced the 2020-21 (pandemic) season, with 23% of swimmers voluntarily opting out. Three COVID-19 cases were confirmed (2%) by the medical staff with no long-term effects. Significant reductions in average swim volume were verified in Sprinters (32,867±10,135 vs.14,800±7,995yards;p<0.001), Mid-Distance (26,457±10,692 vs.17,054±9.923yards;p<0.001), and Long-Distance (37,600±14,430 vs.22,254±14,418yards;p<0.001) swimmers (non-pandemic vs. pandemic season, respectively). In the Regional performance analyses, the Sprinters swam faster (n=8;-0.5±0.6secs), while Mid-Distance (n=10;0.17±2.1secs) and Long-Distance (n=7;6.0±4.9secs) swimmers swam slower (F=11.76;p=0.0003;r2=0.52). Thus, the pandemic caused significant reductions in swim training volume, with Sprinters performing better and Long-Distance swimmers performing worse at Regional Championships.
Thermodynamic Stability of Fenclorim and Clopyralid
Authors: Almeida Ana R.R.P. , Pinheiro Bruno D.A. , Lobo Ferreira Ana I.M.C. , Monte Manuel J.S.
Published: November 2021

The present work reports an experimental thermodynamic study of two nitrogen heterocyclic organic compounds, fenclorim and clopyralid, that have been used as herbicides. The sublimation vapor pressures of fenclorim (4,6-dichloro-2-phenylpyrimidine) and of clopyralid (3,6-dichloro-2-pyridinecarboxylic acid) were measured, at different temperatures, using a Knudsen mass-loss effusion technique. The vapor pressures of both crystalline and liquid (including supercooled liquid) phases of fenclorim were also determined using a static method based on capacitance diaphragm manometers. The experimental results enabled accurate determination of the standard molar enthalpies, entropies and Gibbs energies of sublimation for both compounds and of vaporization for fenclorim, allowing a phase diagram representation of the (p,T) results, in the neighborhood of the triple point of this compound. The temperatures and molar enthalpies of fusion of the two compounds studied were determined using differential scanning calorimetry. The standard isobaric molar heat capacities of the two crystalline compounds were determined at 298.15 K, using drop calorimetry. The gas phase thermodynamic properties of the two compounds were estimated through ab initio calculations, at the G3(MP2)//B3LYP level, and their thermodynamic stability was evaluated in the gaseous and crystalline phases, considering the calculated values of the standard Gibbs energies of formation, at 298.15 K.
Uji Efektivitas Anthelmintik Ekstrak Etanol Daun Kemangi (Ocimum americanum L.) Terhadap Cacing Gelang (Ascaris lumbricoides) Secara In Vitro
Authors: Karim Suhrah Febrina , Farid Nurfiddin , Wahid Hilmiati , Musdalifa Musdalifa
Published: November 2021

Penyakit kecacingan merupakan salah satu penyakit infeksi yang disebabkan oleh masuknya parasit berupa telur cacing kedalam tubuh manusia melalui saluran pencernaan manusia karena adanya pencemaran melalui tanah. Penelitian ini bertujuan untuk mengetahui efek anthelmintik ekstrak etanol daun kemangi (Ocimum americanum L.) terhadap cacing gelang Ascaris lumbricoides dan untuk mengetahui konsentrasi ekstrak etanol daun kemangi (Ocimum americanum L.) yang efektif sebagai anthelmintik terhadap cacing gelang (Ascaris lumbricoides). Penelitian ini merupakan metode eksperimental dengan rancangan acak lengkap. Daun Kemangi di lakukan ekstraksi dengan metode maserasi kemudian dilakukan skrining fitokimia. Hewan uji dibagi menjadi 5 kelompok yaitu Kelompok 1 (ekstrak daun kemangi dosis 10%), Kelompok 2 (ekstrak daun kemangi dosis 20%), Kelompok 3 (ekstrak daun kemangi dosis 30%), Kelompok 4 Kontrol Positif (pirantel pamoat 5 mg/ml) dan Kelompok 5 Kontrol Negatif (NaCl 0,9%). Pengamatan dilakukan tiap 1 jam setelah perendaman sampai semua cacing mati. Hasil penelitian menunjukkan 100% kematian cacing yaitu ekstrak etanol daun kemangi Konsentrasi 10% pada jam ke 24, Konsentrasi 20% pada jam ke 16, dan Konsentrasi 30% pada jam ke 8, Kelompok kontrol positif pada jam ke 2, Kontrol negatif (larutan NaCl 0,9%) pada jam ke 76. Hasil penelitian menunjukkan bahwa konsentrasi ekstrak etanol daun kemangi (Ocimum americanum L.) konsentrasi 30% memberikan efek anthelmintik terhadap cacing gelang (Ascaris lumbricoides) pada jam ke 8.
Activity Test of Durian Peels Essential Oil (Durio zibethinus) as an Antipediculosis Against Pediculus humanus capitis Linn. (Anoplura: Pediculidae)
Authors: Mulyani Yuli Wahyu Tri , Nurjanah Siti , Samsuar Samsuar , Susanti Laila
Published: November 2021

Pediculosis is a disease caused by infestation of head lice (Pediculus humanus capitis) which is a blood-sucking obligate ectoparasite. The essential oil of durian fruit peel has active compounds that have the potential as vegetable pediculosides that can kill head lice. This study aimed to find the best concentration of essential oil from durian fruit peels that can kill head lice. The research design used with an essential oil concentration of 100%, 75%, 50%, 25%, distilled water as negative control and permethrin 1% as positive control, three repetitions and each concentration consisting of 10 flea tails. The parameters observed were the condition of lice morphologically based on the activity of limb movement, antenna movement and digestion, then the calculation of mortality was observed based on the time of the test. The results showed that the concentration of durian peel essential oil as an antipediculosis had a significant effect on the time of death of head lice, limb movement and digestion. The test result showed that the concentration is 100%, has a death time of 12 minutes 32 seconds, 75% concentration was 16 minutes 28 seconds, 50% concentration was 21 minutes 11 seconds, 25% concentration was 32 minutes 23 seconds, negative control was 61 minutes 15 seconds. The fastest time of death in positive control for chemical pediculosides was 10 minutes 15 seconds. The conclusion in this study was that essential oils the dominan one is 1,5-naphthyridin-2-amine were proven to kill head lice and the best concentration was close to positive control, namely at a concentration of 100%.
Penggunaan Low Molecular Weight Heparin untuk Pasien COVID-19 dengan Kehamilan: Studi Literatur
Authors: Juanita Rr Asih , Meriyani Herleeyana , Sanjaya Dwi Arymbhi , Siada Nyoman Budiartha , Purnamasari Putu Sukma
Published: November 2021

COVID-19 atau Coronavirus Disease 2019 merupakan penyakit yang disebabkan oleh virus SARS-CoV-2. COVID-19 dengan kehamilan sangat meningkatkan risiko Tromboemboli Vena (TEV), sehingga diperlukan terapi antikoagulan. Heparin jenis low molecular weight heparin atau LMWH dipilih untuk kehamilan dan menyusui. Tujuan dari penelitian ini yaitu memuat informasi mengenai pemberian profilaksis TEV berupa LMWH pada ibu hamil dengan COVID-19. Metode yang digunakan adalah studi kajian pustaka yang mengumpulkan dan menelaah informasi dari beberapa jurnal atau pedoman terkait dosis pemberian, efek samping, dan rekomendasi pemberian LMWH pada pasien COVID-19 dengan kehamilan oleh badan kesehatan dunia. Hasil kajian yang telah dilakukan, dosis LMWH sebagai profilaksis TEV adalah 4000 IU (40 mg) melalui subkutan sekali sehari. Efek samping penggunaan LMWH memiliki efek yang tidak diinginkan, diantaranya trombositopenia, hipersensitivitas pada kulit, nekrosis pada kulit, pendarahan, osteoporosis dan fraktur. Dalam penggunaannya untuk ibu hamil dengan resiko TEV akibat COVID-19, LMWH memberikan manfaat yang lebih besar. LMWH berperan penting dalam terapi antikoagulan yang dibutuhkan dalam pengobatan modern. Penggunaan LMWH pada pasien COVID-19 dengan kehamilan, harus mempertimbangkan rasio manfaat dan efek samping agar tidak membahayakan kondisi ibu dan janin.
Surface Slip Distribution and Earthquake Rupture Model of the Fuyun Fault, China, Based on High-Resolution Topographic Data
Authors: Liang Zihan , Wei Zhanyu , Sun Wen , Zhuang Qitian
Published: November 2021

The characteristics of earthquake surface ruptures, such as geometry, slip distribution, and coseismic deformation, contain important information about the earthquake rupture process, and so investigations and analyses of earthquake surface rupture have played a crucial role in modern earthquake hazard studies, especially with the increasing availability of high-resolution topographic and imagery data for tectono-geomorphic interpretation. In this study, we use Structure from Motion (SfM) photogrammetry to build a 1 m resolution digital elevation model (DEM) of the fault and combine this with filed observations to map the surface ruptures of the 1931 M8.0 Fuyun earthquake, China. These high-resolution topographic data enable to identify and measure the displaced gullies, and so the rupture locations and along-strike slip distribution are obtained in detail. Four paleoearthquake events are identified through the offset cluster characteristics. The coseismic offset of the 1931 Fuyun earthquake is extracted from the offset distribution, which shows four continuous undulations along the fault strike, corresponding to the four segments of surface rupture. Moreover, a high offset gradient is observed in the step area connected by the rupture segment. These findings, combined with the width and bending angle of the step area at the joint of the rupture segment, indicate that the 1931 Fuyun earthquake was a cascade rupture formed by four rupture segments. This study expands the available offset measurement data of Fuyun fault and confirms the applicability of high-resolution topographic data to active tectonic research.
Integrated Mechanical Earth Modeling for Predicting Sand Production: A Case Study
Authors: Al-Ameri Aymen
Published: November 2021

Sand production is a serious problem in oil and gas wells, and one of the main concerns of production engineers. This problem can damage downhole equipment and surface production facilities. This study presents a sand production case and quantifies sanding risks for an oil field in Iraq.

The study applies an integrated workflow of constructing 1D Mechanical Earth Modeling (MEM) and predicting the sand production with multiple criteria such as shear failure during drilling, B index, and critical bottomhole pressure (CBHP) or critical drawdown pressure (CDDP). Wireline log data were used to estimate the mechanical properties of the formations in the field. The predicted sand production propensity was validated based on the sand production history in the field.

The interpretation results of some wells anticipated in this study showed that when a shear failure occurs during drilling, the B index is around 2 × 104 MPa or less and the CBHP is equal to the formation pore pressure. For this case, sand control shall be carried out in the initial stage of production. On the other hand, when the shear failure does not exist, the B index is always greater than 2 × 104 MPa, and the CBHP is mostly less than the formation pore pressure. In this case, implementing sand control methods could be postponed as the reservoir pressure undergoes depletion. However, for the anticipated field, sand control is recommended to be carried out in the initial stage of well production even when the CBHP is less than the formation pore pressure since sanding will be inevitable when the reservoir pressure depletes to values close to the initial reservoir pressure.

The tentative evaluation of the stress regime showed that a normal fault could be the stress regime for the formations. For a normal fault stress regime, the study explained that when the reservoir permeability is isotropic, an openhole vertical wellbore has less propensity for sand production than a horizontal wellbore. Moreover, when the wellbore azimuth is in the direction of the minimum horizontal stress, the CBHP will be lower than in any other azimuth, and sanding will take place at higher wellbore inclination angles. For the anticipated field, because of the casedhole well completion and the anisotropic reservoir permeability, a horizontal well drilled in the direction of minimum horizontal stress with oriented perforation in the direction of maximum horizontal stress is an alternative method for controlling sand production.
Bioinformatics analysis of NSCLC multi-omics data
Authors: Lehtiö Janne , Arslan Taner , Siavelis Ioannis , Pan Yanbo , Socciarelli Fabio , Berkovska Olena , Umer Husen M. , Mermelekas Georgios , Pirmoradian Mohammad , Jönsson Mats , Brunnström Hans , Brustugun Odd Terje , Purohit Krishna Pinganksha , Cunningham Richard , Asl Hassan Foroughi , Isaksson Sofi , Arbajian Elsa , Aine Mattias , Karlsson Anna , Kotevska Marija , Hanson Carsten Gram , Haakensen Vilde Drageset , Helland Åslaug , Tamborero David , Johansson Henrik J. , Branca Rui M. , Planck Maria , Staaf Johan , Orre Lukas M.
Published: November 2021

The associated publication reports proteogenomic analysis of non-small cell lung cancer (NSCLC), where we identified molecular subtypes with distinct immune evasion mechanisms and therapeutic targets, and validated our classification method in separate clinical cohorts. This protocol describes sections of the bioinformatics analysis of the multi-omics data, namely, data analysis and processing for panel sequencing, identification of cancer- and driver-related proteins in proteomics data, proteogenomics search, and machine learning-based classifiers for NSCLC subtyping. Specifically, a cohort classifier was built using support-vector machine-recursive feature elimination (SVM-RFE) algorithm applied to in-depth proteomics data from a cohort of 141 samples. The classifier was then validated in three external datasets. Another classifier, suitable for single-sample subtyping, was built using k-top scoring pairs (k-TSP) algorithm applied to label-free data from a cohort of 136 samples. The k-TSP-based classifier was validated in two independent cohorts and an additional external dataset.
Lifestyle Medicine Strategies for Combating Sleepiness and Fatigue in Professional Drivers - The "Highway 2 Health" study
Authors: Ntoumas Ilias , Karatzaferi Christina , Dardiotis Efthimios , Sakkas Giorgos K.
Published: November 2021

Sleep has a number of health benefits, including memory and learning, vitality and energy as well as high quality of life levels. Lack of sleep impairs judgment, impacts longevity and safety, and increases the risk of a number of diseases including obesity, hypertension, heart disease, diabetes, mood disorders, and impaired immune function. In addition lack of sleep or disturbance of normal sleep cycle could have a major impact on people's lives and working performance such as driving. Daily sleepiness is a problem concerning professions with a non-fixed schedule. Specifically, professional long-haul drivers confront sleepiness problems and in combination with fatigue, they are prone to driving accidents and other incidents. Sleep quality and quantity are closed related to fatigue which is one of the most common reasons for driving and working accidents. In recent years, car accidents involving professional drives have increased significantly. The main reasons for those accidents were fatigue and sleepiness due to long hours of driving or difficult working conditions according to the recent European report (Driver Fatigue in European Road Transport - etf-europe.org).Lifestyle Medicine addresses health risk factors in primary, secondary, and tertiary prevention of developing disease rather than on acute care and reacting to illness, injury, and disease. Lifestyle Medicine strategies target modifiable risk factors, such as diet, sleep, stress, and physical activity. By applying those regimes the investigators could improve physical and mental health levels that can affect the quality of sleep, reducing daily sleepiness and fatigue, in professional drivers operating coaches and trucks. Any intervention that could improve alertness and reduce fatigue and sleepiness in those people, will automatically improve safety, reduce driving accidents and save lives and resources.The study is registered on the ClinicalTrials.gov public website (NCT05096130).
Assessment of The Renewable Energy Offshore and Wind Energy Markets Affects During The COVID-19 Virus
Authors: Jamali Riaz Hussain , Bughio Amanullah , Das Ghansham , Jamali Rizwan , Niroula Shova , Baloch Zulfiqar Ali
Published: November 2021

The main aims of the current study are to determine during the COVID-19 epidemic effects on renewable and green energy and control the raising the cost of utilizing renewable energy to power for country energy plants using the Levelized Cost of Energy methods. Objective 1) The COVID-19 pandemic can be provided through green financial policies such as coal pricing, transferable green certificates, and loans for renewable energy markets. Objective 2) examined the cost of offshore wind power in china before and after the COVID-19 outbreak, using data from 100 offshore wind power projects constructed between 2000 and 2020. Based on results, wind power's fixed average cost of electricity fell from 0.98 Chinese yuan in 2000 to 0.79 Chinese RMB in March 2019, and subsequently to 0.75 Chinese RMB in 2020, a 13.99 percent increase. Other results average electricity generation price down to 0.79 RMB, 0.99 RMB, and 0.79 RMB and average carbon oxide emissions was 50 RMB/ton increase. The green fiscal policies will be required during the COVID-19 epidemic to promote offshore wind energy generation investment.
Global Burden of Female Breast Cancer: Age-period-cohort Analysis of Incidence Trends from 1990 to 2019 and Forecasts for 2035
Authors: Li Yizhen , Zheng Jinxin , Deng Yujiao , Deng Xinyue , Lou Weiyang , Wei Bajin , Xiang Dong , Hu Jingjing , Zheng Yi , Xu Peng , Yao Jia , Zhai Zhen , Zhou Linghui , Yang Si , Wu Ying , Kang Huafeng , Dai Zhi-Jun
Published: November 2021

Background This study aimed to describe the latest epidemiology of female breast cancer globally, analyze the change pattern of the incidence rates and the disease’s association with age, period, and birth cohort, and subsequently present a forecast of breast cancer incidence.Methods Data for analysis were obtained from Global Burden of Disease (GBD) Study 2019 and World Population Prospects 2019 revision by the United Nations (UN). We described the age-standardized incidence rates (ASIRs) from 1990 to 2019 and then calculated the relative risks of period and cohort using an age-period-cohort model, and predicted the trends of ASIRs to 2035.Results In 2019, the global incidence of breast cancer in women increased to 1,977,212 (95% uncertainty interval = 1 807 615 to 2 145 215), with an ASIR of 45.86 (41.91 to 49.76) per 100 000 persons. Among the six selected countries facing burdensome ASIRs, only the USA showed a downward trend from 1990 to 2019, whereas the others showed an increasing or stable trend. The overall net drift was similar in Japan (1.78%), India (1.66%), and Russia (1.27%), reflecting increasing morbidity from 1990 to 2019. The increase in morbidity was particularly striking in China (2.60%) and not significant in Germany (0.42%). The ASIRs were predicted to continue to increase globally, from 45.26 in 2010 to 47.36 in 2035. In most countries and regions, the age specific incidence rate is the highest in those aged over 70 years and will increase in all age groups until 2035. In high-income regions, the age specific incidence rates are expected to decline in women aged over 50 years. Conclusions The global burden of female breast cancer is becoming more serious, especially in developing countries. Raising awareness of the risk factors and prevention strategies for female breast cancer is necessary to reduce future burden.
The difference of the retinal structural and microvascular characteristics in patients with MOGAD-ON and AQP4-ON
Authors: Yao Yajun , Li Xindi , Xu Yun , Liang Xiaofang , Yang Liu , Shi Fu-Dong , Zhang Xinghu , Tian De-cai
Published: November 2021

Background
Antibodies against myelin-oligodendrocyte-glycoprotein (MOG-Abs) associated disorders (MOGAD) have been recognized as a disease entity in their own right. Optic neuritis (ON) is the most common symptom in MOGAD.
Objective
To demonstrate the differences in retinal microvascular characteristics between patients with MOGAD-ON and aquaporin-4 antibody (AQP4-Ab) positive ON.
Methods
A prospective study in which optical coherence tomography (OCT) and optical coherence tomography angiography (OCTA) were used to measure retinal and microvascular parameters.
Results
22 MOGAD-ON eyes, 32 AQP4-ON eyes and 60 control eyes were included in the study. The thickness of RNFL and GCC in MOGAD-ON eyes is significantly lower than that of HC (p <0.001, respectively), but comparable to AQP4-ON eyes. The vessel density in retina capillary plexus (RCP) reduced significantly in MOGAD-ON than that in AQP4-ON (p < 0.05, respectively). Unlike AQP4-ON, the visual accuracy in MOGAD-ON was positivitly correlated with vessel density of superficial RCP (P = 0.010) and ON relaspe times (P = 0.038).
Conclusion
The retinal neuro-axonal damages between MOGAD-ON and AQP4-ON were comparable. Unlike AQP4-ON eyes, microvascular densities were significantly reduced in MOGAD-ON, and was positively correlated with the deterioration of visual acuity in MOGAD-ON.
Assessing Biomarker Stability and Assay Performance Parameters for the Use of Biomarkers in Mental Disorders; A Study of Early Stage Biomarker Assay Method Development
Authors: jentsch Mike , de Strate Barry van , Meddens Marjolein , Meddens Marcus , Schoevers Robert
Published: November 2021

Within the field of psychiatry the development of biomarker based assay methods is relatively young. Recent efforts focused on combining several biomarkers within a panel to increase discriminative power. However, most biomarker panels have failed to advance to the stage of clinical application. An important prerequisite is a proper sampling and storage procedure, based on a priori identified stability properties of all biomarker/body fluid combinations present in the panel. Second, is the performance requisites of the assays in use, such as Enzyme-Linked Immunosorbent Assays (ELISA), in order to assure reliable results within and between runs. In this study, we analyzed 24 biomarker assays in 32 biomarker/body fluid combinations. Each biomarker body fluid combination was tested for stability and assay performance. We found hampering stability in almost all cases expect three biomarkers in urine and three in serum. Variability in biomarker stability either indicates decreased biomarker stability or issues in assay performance. This study indicates that basic biomarker/body fluid combination stability provides a good starting point for biomarker panel assay development. However, assay performance plays an important role in the correct interpretation of those results. Along the way of assay development, other quality assurance parameters might be implemented focused on a fit for purpose principle ultimately providing reliable data necessary for diagnostical method implementation.