bluuebunny/crossref_metadata_2025 huggingface dataset:
Central nervous system involvement in patients with diffuse large B cell lymphoma: analysis of the risk factors and prognostic from a single-center retrospective cohort study
Authors: Ma Jingjing , Li Qing , Shao Jie , Ma Yan , Lin Zhiguang , Kang Hui , Chen Bobin
Published: October 2019

Purpose The aim of this study was to identify the risk factors for central nervous system (CNS) involvement in systemic diffuse large B-cell lymphoma (DLBCL) patients and to explore prognostic for DLBCL patients with CNS involvement (relapse or progression). Method This was a retrospective cohort study in our hospital. Data were collected from all DLBCL patients diagnosed in our institutes from January, 2013 to June, 2018. Clinical information was collected from medical records. Result The participants included 138 patients with DLBCL. Among them, 38 patients were diagnosed as CNS lymphoma, including 15 patients exhibited CNS involvement while DLBCL were pathologically confirmed, and 23 patients developed CNS lymphoma during or after initial chemotherapy. The median disease-free interval to CNS involvement was 13 months. Multivariate analysis identified elevated serum lactate dehydrogenase(LDH) level [hazard ratio(HR)=4.035; 95% confidence interval(95%CI):1.147~14.195] was independent predictor of CNS involvement. The median progression-free survival (PFS) and overall survival (OS) time of DLBCL patients with CNS involved were 12.5 months and 22 months, respectively. Multivariate prognostic analysis showed that eastern cooperative oncology group (ECOG) score>2(P=0.018; HR=7.333; 95%CI:1.424~42.002), elevated serum LDH level (P=0.046; HR=6.510; 95%CI:1.035~40.949), deep lesion (P=0.005; HR=10.957; 95%CI:2.050~58.569), and CNS with systemic involvement (P=0.023; HR=2.730; 95%CI:1.151~6.479) were independent poor prognostic factors for the patients. The cases with lymphocyte absolute count >0.75×109/L (HR=0.047; 95%CI:0.003~0.732) had better prognosis. The OS of DLBCL patients with secondary CNS lymphoma was inferior to DLBCL patients without CNS involvement. There was no significant difference between the patients with CNS and extra-CNS involvement. There was no significant difference between the patients with CNS involvement and stage III-IV DLBCL cases without CNS lymphoma. Conclusion In conclusion, elevated serum LDH was independent high-risk factor for secondary CNS lymphoma. For patients DLBCL with CNS involvement, ECOG score>2, elevated serum LDH level, deep lesion, lymphocyte absolute count ≤0.75×109/L and CNS with systemic involvement retained a significant association with outcome.
Differences in fear of falling and fall risk indicators among white and black older adults: a cross sectional study
Authors: Bay Allison Anne , Ramachandran Smrithi , Silverstein Hayley A. , Song Jiayang , Hart Ariel R. , Bozorg Ariyana , Hackney Madeleine E.
Published: October 2019

Background Falling among older adults is common and can cause chronic health complications. This study investigated differences between White and Black community-dwelling older adults in fall history, fear of falling, and indicators of fall risk.Methods All assessments and analyses were conducted in a clinical laboratory at Emory University in the Department of General Medicine and Geriatrics on 84 diverse community-dwelling older adults (White, n=37; Black, n=47). Statistical analyses included one-way ANOVA for continuous variables, the Fisher exact test for categorical variables, the Mann-Whitney-Wilcoxon test for ordinal variables, and an ordinal logistic regression model to examine which factors predicted fear of falling. Measures included fall history, fear of falling, and fall risk indicators. The Montreal Cognitive Assessment, Activities-Specific Balance Confidence Score, Gait Speed, Short Form 12 Physical Component Score and Mental Component Score, fear of falling and quality of life rating scales and demographics questionnaires were administered.Results Falls history was not significantly different between groups. Black participants had significantly fewer years of education (p=.007), lower MoCA scores (p=0.002), and slower fast gait speed (p=0.032) than White participants. However, Black participants reported significantly less fear of falling (p=0.043). Race (Black/White) (p=<0.001), sex (p=0.028), preferred gait speed (p=0.036), and a dichotomous variable of use of assistive device for walking (p=0.023) were significant predictors of fear of falling in the logistical model.Conclusions These factors may explain the observed differences in fear of falling observed between white and black groups in this study. This work offers an explanation of possible factors related to the well-documented yet poorly understood fact that while Black older adults have more risk factors for falling, White older adults tend to fall more frequently and are more afraid of falling.
Medication omission rates in New Zealand Residential Aged Care Homes: a national description
Authors: Garratt Stephanie M , Kerse Ngaire M , Peri Kathryn , Jonas Monique F
Published: October 2019

Background Medication administration is a key service offered to individuals residing in residential aged care homes (RAC homes). A medication omission is an event where a prescribed medication is not taken by a resident before the next scheduled dose. Medication omissions are typically classed as errors, they have the potential to lead to harm if poorly managed, but may also stem from good clinical decision-making. Studies that critically appraise or support medication omissions in healthcare settings are limited. There is uncertainty around which medication omissions are problematic and how many on average a patient should experience. There have been several hospital-based studies, with limited sample sizes, timeframes, and inconsistent reporting of omissions. As the first population-level, RAC Home-specific study of its kind, this study quantifies the incidence, prevalence, and types of medication omissions in RAC homes on a national scale. Methods A retrospective review of de-identified, medication administration e-records from December 1 st 2016 to December 31 st 2017 was conducted. Demographic details of residents, care staff competency levels, medications, and RAC ownership types were included in the review and analysis. Results A total of 11, 015 residents from 374 RAC homes had active medication charts; 8,020 resided in care over the entire data collection period. A mean rate of 3.40 medications doses were omitted per 100 dispensed medications doses per resident (s.d. 7.27). Approximately 73% of residents had at least one dose omission. The most common selected omission category was ‘not-administered’ (49.9%), followed by ‘refused’ (34.6%). The mean rate of omission was found to be slightly higher in corporate operated RAC Homes (3.73 versus 3.33), with greater variation. The most commonly omitted medications were Analgesics and Laxatives. Forty-eight percent of all dose omissions were recorded without a comment justifying the omission. Conclusions Compared to other studies medication omissions within RAC homes in New Zealand are not as common as previously proposed. This study sets out the first national-level rate of medication omissions per resident over a one-year timeframe. Subsequent studies will address the medications omitted, the clinical significance of omissions and the place of medication omissions within clinical decision-making.
Sensor-based Characterization of Daily Walking: A New Paradigm in Frailty Assessment
Authors: Kumar Danya Pradeep , Toosizadeh Nima , Mohler Jane , Ehsani Hossein , Laksari Kaveh
Published: October 2019

Background Frailty is an increasingly recognized geriatric syndrome resulting in decline in reserve across multiple physiological systems. Impaired physical function is a prime indicator of frailty.Objective The goal of this study was to develop an algorithm that discriminates between frailty groups (non-frail, pre-frail, and frail) based on gait performance parameters derived from unsupervised daily physical activity (DPA).Methods DPA was acquired for 48 hours from older adults (≥65 years) using a tri-axial accelerometer motion-sensor. Purposeful continuous bouts of walking (≥60s) without pauses were identified from acceleration data. These were then used to extract qualitative measures (gait variability, gait asymmetry, and gait irregularity) and quantitative measures (total continuous walking duration and maximum number of continuous steps) to characterize gait performance. Association between frailty and gait performance parameters was assessed using multinomial logistic models with frailty as the dependent variable, and gait performance parameters along with demographic parameters as independent variables.Results 126 older adults (44 non-frail, 60 pre-frail, and 22 frail, based on the Fried index) were recruited. Step- and stride-times, frequency domain gait variability, and purposeful walking quantitative measures were significantly different between non-frail and pre-frail as well as non-frail and frail groups ( p <0.05). Using the logistic model pre-frail/frail group (vs. non-frail) was identified with 76.8% sensitivity and 80% specificity.Discussion Everyday walking characteristics were found to be associated with frailty. Along with quantitative measures of physical activity, qualitative measures are critical elements representing the early stages of frailty. In-home gait assessment offers an opportunity to screen for and monitor frailty.
Does the Medical Insurance System Play a Real Role in Reducing Catastrophic Economic Burden in Elderly Patients with Cardiovascular Disease in China? Implication for Accurately Targeting Vulnerable Characteristics.
Authors: Ma Meiyan , Li Ye , Wang Nianshi , Wu Qunhong , Jiao Mingli , Shan Linghan , Sun Tao , Li Heng , Gao Han , Fu Xuelian , Tian Wanxin , Xia Qi , Hao Yanhua
Published: October 2019

Abstract
Background:The vulnerability of cardiovascular disease (CVD) patients’ health abilities, combined with the severity of the disease and the overlapping risk factors, can cause such people to bear the economic burden of the disease due to the use of medical services.We estimated the economic burden of patients with CVD，and identified the weak link in the design of the medical insurance.
Methods:Data from 5,610 middle-aged and elderly with CVD were drawn from the 2015 wave of China Health and Retirement Longitudinal Study (CHARLS). The recommended method of the World Health Organization (WHO) was adopted to calculate catastrophic health expenditure (CHE), impoverishment by medical expenses (IME), and applied the treatment-effect model to analyze the determinants of CHE.
Results:The incidence of CHE was 19.9% of the CVD, compared to 7.6% of the sample households trapped in IME. The incidence of CHE in CVD participating in medical insurance was 2.6% higher than for uninsured families (16.3%).Family size, health satisfaction,combine with other chronic diseases, having hospitalization and disabled members, and participating in insurance were found to be significantly associated with the likelihood of CHE.
Conclusions:Elderly with physical vulnerabilities were more prone to CHE. The medical insurance only reduced barriers to accessing health resources for elderly with CVD, but lacked policy inclination for high-utilization populations,and had poorly accurate identification of vulnerable characteristics of CVD,which in turn affects the economic protection ability of the medical insurance. The dispersion between the multiple medical security systems leads to the existence of blind spots in the economic risk protection of individuals and families.
Keywords:cardiovascular disease, catastrophic health expenditure, impoverishment by medical expense, medical insurance, elderly households
A new approach to characterize postural deficits in chemotherapy-induced peripheral neuropathy and to analyze postural adaptions after an exercise intervention
Authors: Kneis Sarah , Wehrle Anja , Dalin Daniela , Wiesmeier Isabella Katharina , Lambeck Johann , Gollhofer Albert , Bertz Hartmut , Maurer Christoph
Published: October 2019

Background Postural instability presents a common and disabling consequence of chemotherapy-induced peripheral neuropathy (CIPN). However, knowledge about postural behavior of CIPN patients is sparse. With this pilot study, we used a new approach to i) characterize postural impairments as compared to healthy subjects, ii) allocate possible abnormalities to a set of parameters describing sensorimotor function, and iii) evaluate the effects of a balance-based exercise intervention.Methods We analyzed spontaneous and externally perturbed postural control in eight CIPN patients before and after a balance-based exercise intervention by using a modification of an established postural control model. These findings were compared to 15 matched healthy subjects.Results Spontaneous sway amplitude and velocity were larger in CIPN patients compared to healthy subjects. CIPN patients’ reactions to external perturbations were smaller compared to healthy subjects, indicating that patients favor vestibular over proprioceptive sensory information. The balance-based exercise intervention up-weighted proprioceptive information in patients.Conclusions CIPN patients’ major postural deficit may relate to underuse of proprioceptive information that results in a less accurate posture control as spontaneous sway results indicate. The balance-based exercise intervention is able to partially correct for this abnormality. Our study contributes to a better understanding of postural impairments in CIPN patients and suggests an effective treatment strategy.
Corneal wavefront guided versus aberration free transepithelial photorefractive keratectomy in myopic patients with high pre-existing corneal higher order aberrations
Authors: Ellakwa Amin Faisal , Zaki Marwa Ali , Ashour Rana Mohammed
Published: October 2019

Objectives:to compare the efficacy, safety and predictability of corneal wavefront guided (WFG) and aberration free ablation in single-step transepithelial photorefractive keratectomy (TransPRK) in myopic patients with high pre-existing corneal higher order aberrations (HOAs).
Background: Corneal WFG and aberration free treatments have been proposed as methods to achieve better visual, refractive, and optical outcomes.
Methods:Non-randomized controlled trialwas conducted in El-HekmaEye-LASIK center, Menoufia governorate, Egypt during the period from January 2017 to December 2017. TransPRK was performed to eligible myopic patients with or without astigmatism with corneal HOAs ≥ 0.35 µmat 6 mm diameter utilizing either optimized (aberration free) or corneal WFG patterns (SCHWIND eye-tech-solutions, Kleinostheim, Germany). Uncorrected distance visual acuity (UDVA), manifest and cycloplegic refractions, best spectacle corrected distance visual acuity (CDVA), thorough slit lamp examination and corneal topography were assessed and repeated six months postoperatively.
Results: Six months postoperatively, 97.6% and 100% of patients achieved MRSE within ± 1D with 76.2% and 66.67% of patients achieved UDVA of ≥20/20 in aberration free and corneal WFG groups respectively. Both groups showed increase in spherical and total corneal HOAs, with no significant difference in corneal WFG (p=0.08, p=0.28 respectively) while significantly higher postoperatively in aberration free group (p<0.001, p=0.001 respectively). Coma and trefoil aberrations declined after corneal WFG technique, yet increased after aberration free one.
Conclusions: both aberration free and corneal WFG TransPRK were safe, effective and predictable in treatment of myopia in patients with high pre-existing corneal HOAs at 6 mm diameter with better aberrometric outcomes in corneal WFG group.
Pituitary apoplexy accompanying temporal lobe epilepsy as a complication: case report
Authors: Shijo Katsunori , Yoshimura Sodai , Mori Fumi , Yamamuro Shun , Sumi Koichiro , Oshima Hideki , Yoshino Atsuo
Published: October 2019

Background : Pituitary apoplexy is an acute clinical syndrome caused by infarction and/or hemorrhage of pituitary adenoma, which typically presents with severe headache, visual deterioration, and endocrine abnormalities. However, temporal lobe epileptic seizure has not been viewed as a symptom of pituitary apoplexy in the literature.
Case presentation : To elucidate further such a rare complication of temporal lobe epilepsy-like seizure, we describe here the rare clinical manifestations of a 55-year-old previously healthy male with pituitary apoplexy harboring headache, combined palsies involving cranial nerves III to VI, endocrinologic disturbances, and temporal lobe epilepsy-like seizure. In addition, we discuss the temporal lobe epilepsy associated with pituitary adenoma based on the literature.
Conclusion : Although further accumulation of clinical data is needed, we would like to emphasize the importance of recognition of temporal lobe epilepsy-like seizure due to pituitary apoplexy, and to suggest that early surgery should be considered as an option in patients displaying such a rare complication.
Physiological and transcriptome analysis reveal molecular mechanism in Salvia miltiorrhiza leaves of near-isogenic male fertile lines and male sterile lines
Authors: Wang Ruihong , Jiang Han , Zhou Ziyun , Guo Hongbo , Dong Juane
Published: October 2019

Background: Our previous study finds that male sterility in Salvia miltiorrhiza could result in stunted growth and reduced biomass, but their molecular mechanisms have not yet been revealed. In this article, we investigate the underlying mechanism of male sterility and its impact on plant growth and metabolic yield by using physiological analysis and mRNA sequencing (RNA-Seq).
Results: In this study, transcriptomic and physiological analysis were performed to identify the mechanism of male sterility in mutants and its impact on plant growth and metabolic yield. Through Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) analysis, it is found that the pathways are mainly enriched in processes including organ development, primary metabolic process and secondary metabolic process. Physiological analysis show that the chloroplast structure of male sterile mutants of S. miltiorrhiza is abnormally developed, which could result in decrease in leaf gas exchange ( A , E and gs ), chlorophyll fluorescence (Fv, Fm and Fv/Fm), and the chlorophyll content. Expression level of 7 differentially expressed genes involved in photosynthesis-related pathways is downregulated in male sterile lines of S. miltiorrhiza , which could explain the corresponding phenotypic changes in chlorophyll fluorescence, chlorophyll content and leaf gas exchange. Transcriptomic analysis establishes the role of disproportionating enzyme 1 ( DPE1 ) as catalyzing the degradation of starch, and the role of sucrose synthase 3 ( SUS3 ) and cytosolic invertase 2 ( CINV2 ) as catalyzing the degradation of sucrose in the S. miltiorrhiza mutants. The results also confirm that phenylalanine ammonialyase ( PAL ) is involved in the biosynthesis of rosmarinic acid and salvianolic acid B, and flavone synthase ( FLS ) is an important enzyme catalyzing steps of flavonoid biosynthesis.
Conclusions: Our results from the physiological and transcriptome analysis reveal underlying mechanism of plant growth and metabolic yield in male sterile mutants, and provide insight into the crop yield of S. miltiorrhiza.
Seeds as Economical Production Platform for Recombinant Proteins
Authors: Khan Muhammad Sarwar , Joyia Faiz Ahmad , Mustafa Ghulam
Published: October 2019

:

The cost-effective production of high-quality and biologically active recombinant molecules especially proteins is extremely desirable. Seed-based recombinant protein production platforms are considered as superior choice owing to lack of human/animal pathogenic organisms, lack of cold chain requirements for transportation and long-term storage, easy scalability and development of edible biopharmaceuticals in plants with objective to be used in purified or partially processed form is desirable. This review article summarizes the exceptional features of seed-based biopharming and highlights the needs of exploiting it for commercial purposes. Plant seeds offer a perfect production platform for high-value molecules of industrial as well as therapeutic nature owing to lower water contents, high protein storage capacity, weak protease activity and long-term storage ability at ambient temperature. Exploiting extraordinarily high protein accumulation potential, vaccine antigens, antibodies and other therapeutic proteins can be stored without effecting their stability and functionality up to years in seeds. Moreover, ability of direct oral consumption and post-harvest stabilizing effect of seeds offer unique feature of oral delivery of pharmaceutical proteins and vaccine antigens for immunization and disease treatment through mucosal as well as oral route.
High Dietary Fat Modulates Neurobehavioural Effect of Lopinavir/ Ritonavir in Mice
Authors: Onaolapo Olakunle J. , Adeyemi Oluwole I. , Amujoyegbe Omolola J. , Fasola Eunice A. , Olofinnade Anthony T. , Onaolapo Adejoke Y.
Published: October 2019

Background:

Lopinavir/Ritonavir (LR) is a protease inhibitor used human immunodeficiency
virus infection management. There have been issues regarding the effects of fat on LR efficacy and
the possibility of neurological deficits following prolonged use, there is however a dearth of research
examining this.

Aims:

The effects of LR administered with normal or High-Fat Diet (HFD) on neurobehaviour, neurochemistry
and oxidative stress in healthy mice were examined.

Methods:

Mice were randomly-assigned into eight groups of ten (n=10) animals each. The groups
were normal control [Standard Diet, (SD)], HFD control, 3 groups of LR incorporated into SD
(100/25, 200/50 and 400/100 mg/kg of feed), and 3 groups of LR with HFD (100/25, 200/50 and
400/100 mg/kg of feed). Mice were fed daily for six weeks, following which open field, elevated-plus
maze (EPM), radial-arm maze and Y-maze behaviours were scored. Twenty-four hours after tests,
mice were euthanised and brains were homogenised for estimation of oxidative stress, L-glutamate
level and acetylcholinesterase activity.

Results:

LR was associated with a reduction in HFD-induced weight gain, suppression of open-field
behaviours with SD, and counteraction of HFD-induced changes in working-memory, open-field and
anxiety-related behaviours. Also, LR causes increased lipid peroxidation and superoxide dismutase activity;
and a decrease in brain glutamate, irrespective of dietary composition. Increased fat catabolism
leading to increased oxidative stress could possibly account for the weight changes, while a decrease in
brain glutamate could account for the changes in open-field behaviours in mice fed SD.

Conclusion:

LR alters neurobehaviour, oxidative stress and brain glutamate in mice; however, only its
effects on neurobehaviour are affected by diet.
Genomic Profiles and Current Therapeutic Agents in Neuroendocrine Neoplasms
Authors: Ohmoto Akihiro , Morizane Chigusa
Published: October 2019

Neuroendocrine neoplasms (NENs) are rare tumors that mainly occur in the gastroenteropancreatic
(GEP) tract and lungs. According to the current World Health Organization classification
for GEP-NENs and lung NENs, treatment strategies differ for well-differentiated and poorly differentiated
subtypes. For well-differentiated GEP-NENs, somatostatin analogues (SSA), peptide receptor
radionuclide therapy, and molecular-targeted agents are approved as the standards of care based on
phase III clinical trial data. Promising data regarding the use of everolimus and the novel SSA pasireotide
for lung NENs are emerging, though additional studies are required to confirm these effects. For
poorly differentiated tumors from the GEP tract and lung, a platinum-based cytotoxic regimen is
widely used. Genomic analysis has recently revealed a diverse pattern of primary organ-dependent
mutations, and the use of traditional treatment strategies versus organ-specific strategies is currently
under discussion. In addition, clinical trials for several molecular-targeted agents and immune checkpoint
inhibitors for the treatment of NENs are currently underway. Accumulating genomic information
is expected to contribute to the development of novel therapies for other organ-derived NENs or
poorly differentiated neuroendocrine carcinomas (NECs). Here, we provide an updated overview of
the current knowledge regarding genomic profiles and representative agents for NENs and highlight
the prospects for future investigations.
Sleep Terrors: An Updated Review
Authors: Leung Alexander K.C. , Leung Amy A.M. , Wong Alex H.C. , Hon Kam Lun
Published: October 2019

Background:

Sleep terrors are common, frightening, but fortunately benign events. Familiarity
with this condition is important so that an accurate diagnosis can be made.

Objective:

To familiarize physicians with the clinical manifestations, diagnosis, and management
of children with sleep terrors.

Methods:

A PubMed search was completed in Clinical Queries using the key terms " sleep terrors"
OR " night terrors". The search strategy included meta-analyses, randomized controlled trials,
clinical trials, observational studies, and reviews. Only papers published in the English literature
were included in this review. The information retrieved from the above search was used in the
compilation of the present article.

Results:

It is estimated that sleep terrors occur in 1 to 6.5% of children 1 to 12 years of age. Sleep
terrors typically occur in children between 4 and 12 years of age, with a peak between 5 and 7
years of age. The exact etiology is not known. Developmental, environmental, organic, psychological,
and genetic factors have been identified as a potential cause of sleep terrors. Sleep terrors tend
to occur within the first three hours of the major sleep episode, during arousal from stage three or
four non-rapid eye movement (NREM) sleep. In a typical attack, the child awakens abruptly from
sleep, sits upright in bed or jumps out of bed, screams in terror and intense fear, is panicky, and has
a frightened expression. The child is confused and incoherent: verbalization is generally present but
disorganized. Autonomic hyperactivity is manifested by tachycardia, tachypnea, diaphoresis,
flushed face, dilated pupils, agitation, tremulousness, and increased muscle tone. The child is difficult
to arouse and console and may express feelings of anxiety or doom. In the majority of cases,
the patient does not awaken fully and settles back to quiet and deep sleep. There is retrograde amnesia
for the attack the following morning. Attempts to interrupt a sleep terror episode should be
avoided. As sleep deprivation can predispose to sleep terrors, it is important that the child has good
sleep hygiene and an appropriate sleeping environment. Medical intervention is usually not necessary,
but clonazepam may be considered on a short-term basis at bedtime if sleep terrors are frequent
and severe or are associated with functional impairment, such as fatigue, daytime sleepiness,
and distress. Anticipatory awakening, performed approximately half an hour before the child is
most likely to experience a sleep terror episode, is often effective for the treatment of frequently
occurring sleep terrors.

Conclusion:

Most children outgrow the disorder by late adolescence. In the majority of cases, there
is no specific treatment other than reassurance and parental education. Underlying conditions, however,
should be treated if possible and precipitating factors should be avoided.
Compressive Strength and Slump Prediction of Two Blended Agro Waste Materials Concretes
Authors: Onikeku Oluwaseye , Shitote Stanley M. , Mwero John , Adedeji Adeola. A. , Kanali Christopher
Published: October 2019

Background:

Agro industrial wastes such as Bamboo Leaf Ash (BLA) and Bagasse Ash (BA) need to be employed so as to replace cement in order to produce cheaper concrete, which, in turn, save the environment.

Objective:

This research focuses on the compressive strength and slump based on Artificial Neural Network (ANN) and Multiple Linear Regression (MLR) models for forecasting of compressive strength and slump value for concrete by blending BLA and BA as partial supplementary cement materials accordingly.

Methods:

Three-layer perceptron was constructed through R (nnet package). A sum total of eleven artificial neural networks were formulated using 214 data sets attained from 27 laboratory concrete mixtures performed.

Results:

The neural network model forecasted the compressive strength for training, testing and validation with predicted errors of 0.802 MPa and 1.380 MPa. The model over forecasted the compressive strength averagely by 0.644 MPa and 1.905 MPa. The forecasted compressive strength changed averagely by 2.328% and 3.946%. The average difference between the predicted and experimental values was 0.588 MPa and 1.050 MPa. The coefficients of determination were 0.961 and 0.905. The MLR model predicted the slump with predictive error values of 6.634 mm and 8.374 mm. The predicted slump deviated on average by 3.633% and 8.034%. The residual error was 3.075 on 12 degrees of freedom. The multiple R2 and adjusted R2 were 0.9336 and 0.9115. The P-value was found to be 5.639e-07.

Conclusion:

The results show that ANN and MLR are potent tools for forecasting the compressive strength and slump of concrete blending bamboo leaf ash and baggage ash. Hence, this contributes towards forecasting of the compressive strength and slump of BLA and BA blended concrete. They extends 28 days compressive strength usually found in the literature to 56 and 90 days compressive strength and there was a remarkable improvement as curing age increases. The slump of combined effect of blending BLA and BA at different percentage replacements was tested. In this study, we used BLA blended with BA to produce concrete which is an innovation.
Karakterisasi Grinding Balls Produksi CV Baja Ellips
Authors: Leman Arianto , Tiwan Tiwan , Nurdjito Nurdjito
Published: October 2019

This research is aimed to study the characteristics of cast grinding balls produced by CV Baja Ellips Ceper, Klaten. The samples were taken from three tapping. One group was quenched in water while the other was not. The studied characteristics comprised of chemical composition, microstructure, hardness and wear. The result shows that the grinding balls have the chemical composition of medium-strength cast iron. However, the microstructure shows cementite and pearlite that indicates the structure of a white cast iron. The hardness of quenched and unquenched grinding balls are 60 HRC and 57 HRC, respectively. The hardness is consistent from the edges to the middle of the grinding balls. The specific wear of quenched grinding balls and unquenched grinding balls is 3.32963 x 10-06 mm2/kg and 5.032 x 10-06 mm2/kg, respectivelyPenelitian ini bertujuan untuk mengetahui karakteristik grinding balls produksi CV Baja Ellips Ceper Klaten yang dibuat dengan menggunakan proses pengecoran. Sampel grinding balls diambil dari tiga kali tapping yang berbeda. Satu kelompok dicelup dingin dalam air dan yang tidak dicelup dingin. Karakterisasi yang dilakukan meliputi komposisi kimia, struktur mikro, kekerasan dan keausan. Hasil penelitian menunjukkan bahwa komposisi kimia dari bola penggiling termasuk dalam kelas besi tuang kekuatan sedang. Struktur mikro yang tampak adalah sementit dan perlit yang menunjukkan struktur besi tuang putih. Kekerasan grinding balls yang dicelup dingin adalah 60 HRC sedangkan yang tanpa dicelup dingin sebesar 57 HRC. Kekerasan grinding balls konsisten dari bagian tepi sampai bagian tengah. Keausan spesifik grinding balls yang dicelup dingin dan tanpa dicelup dingin berturut-turut 3,32963 x 10-06 mm2/kg dan 5,032 x 10-06 mm2/kg
Perbedaan Unjuk Kerja Mesin Menggunakan Electronic Control Unit Tipe Racing dan Tipe Standar pada Sepeda Motor Automatic
Authors: Rahman Rifki Mufti , Widjanarko Dwi , Wijaya M. Burhan Rubai
Published: October 2019

The achievement of electronic-based motorcycle engine or Fuel Injection (FI) has better capability or power compared to conventional system vehicles. This research aims to determine the performance difference of using racing electronic control unit (ECU) compared to standard ECU of an automatic motorcycle. The experiment was carried out on a Honda Vario 125cc motorcycle manufactured in 2013. The research method is experimental research and uses descriptive statistic method. Research findings inform that the maximum torque of the standard ECU is 16.63 Nm at 3500 rpm, and the maximum power is 6.36 KW at 4500 rpm. The racing ECU (Iquteche) has a maximum torque of 22.42 Nm at 2500 rpm, and maximum power of 7.70 kW. The apparent increase in torque is around 36.58 % and in power is around 33.9 %. It can be concluded that the Iquteche ECU provides a more optimized engine performance on an automatic motorcycle.Prestasi mesin sepeda motor berbasis elektronik atau Fuel Injection (FI) memiliki kemampuan atau tenaga yang lebih baik dibandingkan dengan kendaraan sistem konvensional. Penelitian ini bertujuan untuk mengetahui perbedaan unjuk kerja mesin menggunakan Electronic Control Unit tipe racing dan tipe standar pada sepeda motor automatic. Objek penelitian dilakukan pada kendaraan Honda Vario 125cc tahun pembuatan 2013. Penelitian dilakukan dengan menggunkan metode experimental serta analisis data statistik deskriptif. Hasil penelitian menunjukkan bahwa diperoleh data torsi maksimal ECU standar sebesar 16.63 N.m pada putaran 3500 rpm, dan daya tertinggi sebesar 6.36 kW pada putaran 4500 rpm. Sedangkan hasil pengujian menggunakan ECU Iquteche diperoleh torsi tertingi sebesar 22.42 N.m pada putaran 2500 rpm, dan daya tertinggi sebesar 7.70 kW. Selain itu juga diketahui adanya peningkatan torsi mesin sebesar 36.58% dan peningkatan daya sebesar 33.99%, serta diketahui juga bahwa penggunaan ECU Iquteche lebih efektif untuk meningkatkan unjuk kerja mesin pada kendaraan jenis sepeda motor automatic.
Corrupción entre particulares:
Authors: Artaza Varela Osvaldo
Published: October 2019

The phenomenon of criminalization of corruption in the private sector by considering a series of distinctions, detected in a comparative criminal law analysis, regarding the justification of its criminalization: the problem of the legal interests that may be protected through this crime. But also, by identifying a series of interpretative problems that may present as an outcome of the specific criminalization formula adopted by the legislator. In this sense, it is pretended to account for a series of difficulties associated to its criminalization, related to the possibility of emergence of some misunderstandings that may diminish the correct application of the crime, especially considering the legal interests that it pretends to protect.
Cuantificación química de lípidos en cultivos semihidropónicos de tomate en estrés salino – alternativa para proyectos en cursos semestrales
Authors: Salas Asencios Ramsés , Monteghirfo Gomero Mario
Published: October 2019

Se evaluó el contenido de lípidos totales, triglicéridos y esteroles de cultivos semihidropónicos de tomate (Solanum lycopersicon) en condiciones de estrés salino, utilizando métodos químicos de cuantificación.  Los resultados muestran una movilización de las fracciones lipídicas en respuesta a la salinidad similar a lo reportado por otros trabajos de investigación, lo que permite concluir que los métodos químicos utilizados son una buena alternativa para realizar experimentos similares dentro de un curso de pregrado.
Experiencias con el empleo del Zn y aleaciones Zn-Al en la enseñanza de materiales y manufactura
Authors: Barba-Pingarrón Arturo , Gonzalez Parra Jesús Rafael , Covelo Villar Alba , Valdez Navarro Raúl Gilberto , Martínez Flores Esperanza Elizabeth , Hernández Gallegos Miguel Angel , Cabrera Marrero José María , Torres Villaseñor Gabriel Jorge
Published: October 2019

En este trabajo se reúnen una serie de actividades experimentales que se han generado,  usando al Zinc y a las aleaciones Zn-Al como recurso didáctico para la enseñanza  de materias del ámbito de los Materiales, de la Manufactura y de la Ingeniería de Superficies. Se proponen, asimismo, experiencias que se pueden incluir en el futuro y se presenta un análisis de las ventajas y limitaciones de la utilización del zinc y las aleaciones Zn-Al, todo esto como una alternativa atractiva para mejorar los resultados del proceso enseñanza-aprendizaje en estas asignaturas. Entre las ventajas de estos recursos conviene señalar que el procesamiento ocurre a temperaturas mucho menores de las convencionalmente empleadas con aceros y que se puede tener una gama de opciones adicionales para la enseñanza de novedosos procesos.
A INFLUÊNCIA ESTRANGEIRA E AS IDEIAS DE BERNARDO SOUZA FRANCO SOBRE A QUESTÃO BANCÁRIA NO ÂMBITO REGIONAL E NACIONAL: PARÁ-BRASIL (1846-1848)
Authors: Gambi Thiago Fontelas Rosado
Published: October 2019

Este estudo explora as ideias de Souza Franco sobre a questão bancáriaem âmbito regional e nacional e, com base nisso, objetiva apresentar seu diagnósticosobre o sistema bancário brasileiro, analisar seus argumentos em defesa da criaçãode bancos no Brasil e na província do Pará e identificar aspectos que indiquem aassimilação de ideias e experiências estrangeiras e sua adaptação à realidade brasileira.No primeiro caso, analisa-se uma série de cinco artigos sobre a criação de um bancocomercial na província do Pará publicados em 1846 no jornal paraense Treze deMaio. No segundo caso, consideram-se o diagnóstico e a proposta sobre o sistemabancário brasileiro apresentados no livro Os bancos do Brasil, publicado originalmenteem 1848. A argumentação de Souza Franco apresentada nos textos analisados nestetrabalho revelam que as ideias econômicas estrangeiras eram conhecidas, assim comoas experiências vindas do exterior. Esse conhecimento era assimilado criticamente eadaptado às circunstâncias regionais e nacionais. Considerar as ideias de Souza Francobaseadas em assimilações críticas e adaptações de ideias e experiências estrangeirasnão implica dizer que elas significassem mudanças qualitativas na estrutura econômicae política do império.
OS SENTIDOS DA AÇÃO ESTATAL NOS ANOS 1930: CENTRALIZAÇÃO POLÍTICA E INTERVENCIONISMO NA CONSTITUIÇÃO DE 1934
Authors: Varaschin Jorge Armindo Aguiar
Published: October 2019

O presente trabalho apresenta-se como um esforço de interpretação donovo sentido da ação estatal institucionalizado na Constituição de 1934, primeira cartaconstitucional elaborada no pós-Revolução de 1930, período em que se desmanchao bloco de poder hegemônico durante a Primeira República. Dessa forma, atravésda análise das contradições específicas do momento histórico, busca-se compreenderas descontinuidades apresentadas pela nova conjuntura, na medida em que a formaassumida pelo Estado nacional estabelece um processo de centralização política e deconstrução de instrumentos jurídico-institucionais para o intervencionismo econômico,marcando uma nítida diferença em relação ao liberalismo da Constituição de 1891.
Enhanced sintering and nonlinear dielectric properties of Ba0.6Sr0.4TiO3 ceramics with a small amount of lithium additive
Authors: Zhang Xiao-Fei , Xie Xiao-Bin , Xu Qing , Chen Min , Chen Dong-Chu , Huang Duan-Ping , Zhang Feng
Published: October 2019

The powders with the nominal compositions of Ba0.6Sr0.4TiO3+x wt.% Li2CO3
(x=0 and x=1.0) were synthesized by a citrate precursor method. The
sintering behavior, structure and dielectric properties of the ceramic
specimens were investigated. Compared with the lithium-free specimen (x=0),
the lithium-added specimen (x=1.0) showed appreciably enhanced sintering
properties, achieving a relative density of 96.0% after sintering at 900?C.
The enhanced sintering properties were related to a liquid-phase sintering
mechanism. The origin of the liquid-phase was explained. The effects of the
liquid-phase on the densification progress of the lithium-added specimen in
different sintering stages were elucidated. The lithium addition was found
to be beneficial to the nonlinear dielectric properties. The ceramic
specimen with x=1.0 exhibited a figure-of-merit of 106 under a bias electric
field of 20 kV/cm, higher by ~60% than the value (67) for the specimen with
x=0.
Spectroscopic characterization of LiFePO4 as cathode material for Li-ion battery prepared in the pulse thermo-acoustic reactor
Authors: Lazarevic Zorica , Krizan Gregor , Krizan Janez , Milutinovic Aleksandra , Gilic Martina , Kuryliszyn-Kudelska Izabela , Romcevic Nebojsa
Published: October 2019

Lithium iron phosphate (LiFePO4) is a cathode material for the
rechargeable-lithium batteries. In this paper is presented a novel method of
fabrication carbon-coated LiFePO4 in a pilot reactor built according to the
principles of the thermo-acoustic burner of Helmholtz-type. Crystalline
powder with a high percentage of LiFePO4 was synthesized by incomplete
combustion, i.e. in the reductive atmosphere, and calcined at 700?C for 6
h. The obtained samples were characterized by X-ray diffraction, IR and
Raman spectroscopy. The aim of this study was to demonstrate the production
of the high-quality lithium-ion cathode material by the incomplete
combustion. The synthesis of LiFePO4 is completed during calcination and an
ordered structure is attained. Fast synthesis in the reactor (less than 2 s)
is achieved due to the reduction in the size of reactant's particles and a
huge number of collisions owing to their strong turbulent flow associated
with explosive combustion.
Bacteriological Study Of Dental Caries Infection In Baquba
Authors: Turki Somya Hassan , Mubaruk Kareem I.
Published: October 2019

This Study was done form the period October 2016 Until June 2017 In the central laboratory of a hospital belonging to Diyala Health governorate, to isolate and diagnoses Streptococcus mutans bacteria form dental caries infection , their ability in biofilm formation, and the detection of the sensitive antibiotic isolates the inhibitory effect of plant extracts for Green tea and Capsicum annuum on the growth of the bacteria.The results showed that 68 Isolates belonged to Oral Streptococci from 150 samples taken from dental caries infection, 20 isolates (13.3%) of S. mutans bacteria were obtained .the ability of isolate to format of biofilms by (80%), The isolates varied in their sensitivity to antibiotic, Where the percentages of sensitivity for Tetracycline (70), Erythromycin (%65), Streptomycin (% 60), Ciprofloxacin (50)% , While whereas resistance to antibiotics Amoxicillin , Ampicillin, Cefepime, Optochin (100%).the Value of Minimum Inhibition Concretion (MIC) of Tetracycline ranging from (256-1024) micrograms \ ml ,While For antibiotic Erythromycin ranged from (64-1024 ) micrograms \ ml. The highest inhibitory effect of chili pepper and Green tea extracts was (30 and 27) mm respective , So we conclude that the extracts for the chili pepper, green tea have inhibitory ability than more those antibiotics against S.mutansBacteria .This refers to the possibility of benefiting from those extracts in the manufacture of an alternative treatment, for the purpose of minimizing the risks of resistance of bacterial as well as redactor side effects that can result from the use of such antibiotics, in addition, advantages are easy to get and cheaply priced.
Simulation Effect of Stability Classes on SO 2 Concentration in Daura Refinery and Neighboring Regions
Authors: Anad Abbas majeed , Al-Jiboori Monim H. , Hassoon Ahmed F.
Published: October 2019

Sulfur dioxide (SO 2 ) is one of the most dangerous pollutants in the air. Most of the gas isemitted from industrial sources, mainly steam power plants, which account for more than 50%of it. Its consider toxic gas that cause irritating respiratory effects in this study the effect of airpollution around Durra refinery and its neighborhood. Where adopted in the study. the data ofgaseous pollutants in the air (sulfur dioxide) were analyzed in the area south of Baghdad atJanuary month that is have high frequent of stability condition . The data provided by theMinistry of Oil / Baghdad for 2017. In addition, the effect of air stability classes on thequantities of this pollutant. The results of the study showed that the in atmospheric stabilityclass (F) concentrations of sulfur oxides is (54442mg/m 3 ) at distance 100m and (5127 mg/m 3 )at distance 10000m were the highest in the region. Overall results show that the concentrationrates reached relatively high values during the stable and very stable atmospheric stability andthat the values for the month of January for sulfur dioxide were found to be high and areinversely proportional to the speed of the wind.
Determination of Cefixime Using Batch, Cloud Point Extraction and Flow Injection as New Spectrophotometric Methods
Authors: Abood Nisreen kais , M. Hassan Mohammed Jasim , AL-Da'amy Muneer A.
Published: October 2019

Three simple, sensitive, selective, accurate and efficient spectrophotometric methodsfor determining cefixime in bulk drug and pharmaceutical formulations havedescribed. The first method involved conversion of NH 2 in cefixime to diazoniumsalt, which has coupled with Bisphenol A in an alkaline medium. The orange coloredproduct showed λ max at 490 nm and followed Beer's law over a concentration range of1-50 μg mL -1 , with molar absorptivity of 0.866×10 4 L.mol -1 .cm -1 and the detectionlimit was 0.157 μg.mL -1 . The second method involved pre-concentration of a traceamount of cefixime-azo dyes using cloud point extraction (CPE). The extracted drug-dye was spectrophotometrically measured at λ max 500. The constructed calibrationcurve to determine cefixime followed Beer’s law in a range of 0.25-6 μg.mL -1 , with acorrelation coefficient of 0.9998, molar absorptivity of 0.961×10 5 L.mol -1 .cm -1 andthe detection limit was equal to 0.031 μg.mL -1 . The pre-concentration factor was 25and distribution coefficient (D) was 314.03.A diazotization of the studied drug (cefixime) and its coupling with Bisphenol A wasstudied using a developed flow injection analysis method, based on the detection ofthe absorption of the diazotization product. Chemical and physical properties [ofwhat??] were studied to develop the suggested method and to determine the stabilityof the colored of product. A flow rate of 2.5 mL.min -1 , 50 cm reaction coil and 100μL sample volume were used to operate the system and the orange colored productwas detected at 490 nm. The proposed three methods were successfully applied todetermine cefixime in pharmaceutical formulation, where results were satisfactory
Analytical Approximations for Nonlinear Integro-Differential Equations
Authors: Hasan Nabaa najdi , Nasif Majid R.
Published: October 2019

In this work, we are concerned with how to find a solution for the nonlinear integralandointegro-differentialeequationsuusingttwoomethodsoLaplaceotransformiseriesidecomposition method (LTSDM) and Sumuduutransform series decomposition method(STSDM). In these methods, the nonlinear part of the equation described in Adomianidecomposition series. The Laplace and Sumudu methods are found to be reliable andaccurate. Four examples are discussed to check the applicability and the simplicity of thesemethods. Finally, the results are tabulated and displayed graphically to make comparisonsbetween the approximate and exact solutions.