bluuebunny/crossref_metadata_2025 huggingface dataset:
Effects of Graphene Reinforcement on Static Bending, Free Vibration, and Torsion of Wind Turbine Blades
Authors: Kim Hyeong Jin , Cho Jin-Rae
Published: July 2024

Renewable energy markets, particularly wind energy, have experienced remarkable growth, predominantly driven by the urgent need for decarbonization in the face of accelerating global warming. As the wind energy sector expands and turbines increase in size, there is a growing demand for advanced composite materials that offer both high strength and low density. Among these materials, graphene stands out for its excellent mechanical properties and low density. Incorporating graphene reinforcement into wind turbine blades has the potential to enhance generation efficiency and reduce the construction costs of foundation structures. As a pilot study of graphene reinforcement on wind turbine blades, this study aims to investigate the variations of mechanical characteristics and weights between traditional fiberglass-based blades and those reinforced with graphene platelets (GPLs). A finite element model of the SNL 61.5 m horizontal wind turbine blade is used and validated by comparing the analysis results with those presented in the existing literature. Case studies are conducted to explore the effects of graphene reinforcement on wind turbine blades in terms of mechanical characteristics, such as free vibration, bending, and torsional deformation. Furthermore, the masses and fabrication costs are compared among fiberglass, CNTRC, and GPLRC-based wind turbine blades. Finally, the results obtained from this study demonstrate the effectiveness of graphene reinforcement on wind turbine blades in terms of both their mechanical performance and weight reduction.
ANN Prediction of Laser Power, Cutting Speed, and Number of Cut Annual Rings and Their Influence on Selected Cutting Characteristics of Spruce Wood for CO2 Laser Processing
Authors: Ružiak Ivan , Igaz Rastislav , Kubovský Ivan , Tudor Eugenia Mariana , Gajtanska Milada , Jankech Andrej
Published: July 2024

In this work, we focus on the prediction of the influence of CO2 laser parameters on the kerf properties of cut spruce wood. Laser kerf cutting is mainly characterized by the width of kerf and the width of the heat-affected zone, which depend on the laser power, cutting speed, and structure of the cut wood, represented by the number of cut annual rings. According to the measurement results and ANN prediction results, for lower values of the laser power (P) and cutting speed (v), the effect of annual rings (ARs) is non-negligible. The results of the sensitivity analysis show that the effect of v increases at higher energy density (E) values. With P in the range between 100 and 500 W, v values between 3 and 50 mm·s−1, and AR numbers between 3 and 11, the combination of P = 200 W and v = 50 mm·s−1, regardless of the AR value, leads to the best cut quality for spruce wood. In this paper, the main goal is to show how changes in the input parameters affect the characteristics of the cutting kerf and heat-affected zones for all possible input parameter values.
Comparison between Mechanical Properties and Joint Performance of AA 2024-T351 Aluminum Alloy Welded by Friction Stir Welding, Metal Inert Gas and Tungsten Inert Gas Processes
Authors: Milčić Miodrag , Klobčar Damjan , Milčić Dragan , Zdravković Nataša , Đurić Aleksija , Vuherer Tomaž
Published: July 2024

The aim of this work is to study joining Al 2024-T3 alloy plates with different welding procedures. Aluminum alloy AA 2024-T351 is especially used in the aerospace industry. Aluminum plates are welded by the TIG and MIG fusion welding process, as well as by the solid-state welding process, friction stir welding (FSW), which has recently become very important in aluminum and alloy welding. For welding AA2024-T35 with MIG and TIG fusion processes, the filler material ER 4043—AlSi5 was chosen because of reduced cracking. Different methods were used to evaluate the quality of the produced joints, including macro- and microstructure evaluation, in addition to hardness and tensile tests. The ultimate tensile strength (UTS) of the FSW sample was found to be 80% higher than that of MIG and TIG samples. The average hardness value of the weld zone of metal for the MIG- and TIG-produced AA2024-T3511 butt joints showed a significant decrease compared to the hardness of the base metal AA2024-T351 by 50%, while for FSW joints, in the nugget zone, the hardness is about 10% lower relative to the base metal AA2024-T3511.
Performance Evaluation of Thermal Insulation Materials from Sheep’s Wool and Hemp Fibres
Authors: Vėjelis Sigitas , Vaitkus Saulius , Skulskis Virgilijus , Kremensas Arūnas , Kairytė Agnė
Published: July 2024

In the current work, the performance properties of natural-fibre-based thermal insulation materials were examined. For this purpose, three different compositions of natural fibres were prepared: pure sheep wool (SW), wool and industrial hemp (SW/HF) fibres, and pure industrial hemp (HF) fibres. Low-melt bicomponent polylactide (PLA) fibres were used as a binding material. For specimens prepared from natural fibres, the dependence of the thermal conductivity, the tensile strength along and across the direction of product formation, and the short-term water absorption on the density of the specimens and the flammability parameters were determined. In addition, to reduce the water absorption and flammability, the specimens were coated with hydrophobic agents and flame retardants. The obtained research results were also statistically processed. The analysis of the results showed that the thermal conductivity of natural-fibre-based thermal insulation materials varied within the range of 0.0333 ÷ 0.0438 W/(m·K), the tensile strength varied from 2.5 to 130 kPa, the short-term water absorption varied from 0.5 to 8.5 kg/m2, and the water vapour diffusion resistance factor varied from 2.537 to 2.667. It was additionally determined that all the studied products were flammable. The water absorption and flammability values were significantly reduced by the use of hydrophobic agents and flame retardants.
The Mineral Apposition Rate on Implants with Either a Sandblasted Acid-Etched Implant Surface (SLA) or a Nanostructured Calcium-Incorporated Surface (XPEED®): A Histological Split-Mouth, Randomized Case/Control Human Study
Authors: Menhall Abdallah , Lahoud Pierre , Yang Kyung Ran , Park Kwang Bum , Razukevicius Dainius , Traini Tonino , Makary Christian
Published: July 2024

This study aimed to histologically evaluate the effects of XPEED® and SLA surface on the mineral apposition rate (MAR) at 3 and 5 weeks in titanium dental implants placed in human bone. In total, 17 titanium dental implants with XPEED® surface (n = 9) used as test and SLA surface (n = 8) used as control were included in this study. Each patient received four doses of tetracycline 500 mg at 12 h intervals 2 weeks prior to biopsy retrieval. Implant retrieval was performed, and retrieved biopsies were carefully treated for histomorphometric evaluation under epifluorescence microscopy. At 3 and 5 weeks, newly formed bone appeared in direct contact with both types of tested surfaces. At 3 weeks, the MAR value was, respectively, 2.0 (±0.18) μm/day for XPEED® implants and 1.5 (±0.10) μm/day for SLA implants (p = 0.017). At 5 weeks, lower MAR values for both XPEED® and SLA implants were noted, with 1.2 (±0.10) μm/day and 1.1 (±0.10) μm/day, respectively (p = 0.046). The overall evaluation by linear regression analysis for both time and implant surfaces showed a decreased osteoblast activity at 5 weeks compared to 3 weeks (p < 0.005). The results of the present study show that the bone apposition rate occurs faster around implants with XPEED® surface at 3 weeks and 5 weeks of healing. MAR values may support the use of implants with XPEED® surfaces in early loading protocols.
Electronic Properties of Group-III Nitride Semiconductors and Device Structures Probed by THz Optical Hall Effect
Authors: Armakavicius Nerijus , Kühne Philipp , Papamichail Alexis , Zhang Hengfang , Knight Sean , Persson Axel , Stanishev Vallery , Chen Jr-Tai , Paskov Plamen , Schubert Mathias , Darakchieva Vanya
Published: July 2024

Group-III nitrides have transformed solid-state lighting and are strategically positioned to revolutionize high-power and high-frequency electronics. To drive this development forward, a deep understanding of fundamental material properties, such as charge carrier behavior, is essential and can also unveil new and unforeseen applications. This underscores the necessity for novel characterization tools to study group-III nitride materials and devices. The optical Hall effect (OHE) emerges as a contactless method for exploring the transport and electronic properties of semiconductor materials, simultaneously offering insights into their dielectric function. This non-destructive technique employs spectroscopic ellipsometry at long wavelengths in the presence of a magnetic field and provides quantitative information on the charge carrier density, sign, mobility, and effective mass of individual layers in multilayer structures and bulk materials. In this paper, we explore the use of terahertz (THz) OHE to study the charge carrier properties in group-III nitride heterostructures and bulk material. Examples include graded AlGaN channel high-electron-mobility transistor (HEMT) structures for high-linearity devices, highlighting the different grading profiles and their impact on the two-dimensional electron gas (2DEG) properties. Next, we demonstrate the sensitivity of the THz OHE to distinguish the 2DEG anisotropic mobility parameters in N-polar GaN/AlGaN HEMTs and show that this anisotropy is induced by the step-like surface morphology. Finally, we present the temperature-dependent results on the charge carrier properties of 2DEG and bulk electrons in GaN with a focus on the effective mass parameter and review the effective mass parameters reported in the literature. These studies showcase the capabilities of the THz OHE for advancing the understanding and development of group-III materials and devices.
Bearing Health State Detection Based on Informer and CNN + Swin Transformer
Authors: Liu Chunyang , Zou Weiwei , Hu Zhilei , Li Hongyu , Sui Xin , Ma Xiqiang , Yang Fang , Guo Nan
Published: July 2024

In response to the challenge of timely fault identification in the spindle bearings of machine tools operating in complex environments, this study proposes a method based on a combination of infrared imaging with an Informer and a CNN + Swin Transformer. The aim is to achieve real-time monitoring of bearing faults, precise fault localization, and classification of fault severity. To accomplish this, an angular contact ball bearing was chosen as the research subject. Initially, an infrared image dataset was constructed, encompassing various fault positions and degrees, by simulating different forms of bearing faults. Subsequently, an Informer-based bearing temperature prediction model was established to select faulty bearing data. Lastly, the faulty data were input into the CNN + Swin Transformer model for bearing fault recognition and classification. The results demonstrate that the Informer model accurately identifies abnormal temperature rises during bearing operation, effectively screening out faulty bearings. Under steady-state conditions, the model achieves a classification accuracy of 97.8%. Furthermore, after employing the Informer screening process, the proposed model exhibits a recognition precision of 98.9%, surpassing other models such as CNN, SVM, and Swin Transformer, which are mentioned in this paper.
Simulations and Bisimulations between Weighted Finite Automata Based on Time-Varying Models over Real Numbers
Authors: Stanimirović Predrag S. , Ćirić Miroslav , Mourtas Spyridon D. , Brzaković Pavle , Karabašević Darjan
Published: July 2024

The zeroing neural network (ZNN) is an important kind of continuous-time recurrent neural network (RNN). Meanwhile, the existence of forward and backward simulations and bisimulations for weighted finite automata (WFA) over the field of real numbers has been widely investigated. Two types of quantitative simulations and two types of bisimulations between WFA are determined as solutions to particular systems of matrix and vector inequations over the field of real numbers R. The approach used in this research is unique and based on the application of a ZNN dynamical evolution in solving underlying matrix and vector inequations. This research is aimed at the development and analysis of four novel ZNN dynamical systems for addressing the systems of matrix and/or vector inequalities involved in simulations and bisimulations between WFA. The problem considered in this paper requires solving a system of two vector inequations and a couple of matrix inequations. Using positive slack matrices, required matrix and vector inequations are transformed into corresponding equations and then the derived system of matrix and vector equations is transformed into a system of linear equations utilizing vectorization and the Kronecker product. The solution to the ZNN dynamics is defined using the pseudoinverse solution of the generated linear system. A detailed convergence analysis of the proposed ZNN dynamics is presented. Numerical examples are performed under different initial state matrices. A comparison between the ZNN and linear programming (LP) approach is presented.
Disrupted Microbiota of Colon Results in Worse Immunity and Metabolism in Low-Birth-Weight Jinhua Newborn Piglets
Authors: Li Jiaheng , Wei Zeou , Lou Fangfang , Zhang Xiaojun , Duan Jiujun , Luo Chengzeng , Hu Xujin , Tu Pingguang , Liu Lei , Zhong Ruqing , Chen Liang , Du Xizhong , Zhang Hongfu
Published: July 2024

The Jinhua pig is well known in China due to its delicious meat. However, because of large litter size, low birth weight always happens. This experiment used this breed as a model to research bacterial evidence leading to growth restriction and provide a possible solution linked to probiotics. In this experiment, the differences in organs indexes, colonic morphology, short chain fatty acid (SCFA) concentrations, microbiome, and transcriptome were detected between piglets in the standard-birth-weight group (SG) and low-birth-weight group (LG) to find potential evidence leading to low birth weight. We found that LG piglets had a lower liver index (p < 0.05), deeper colonic crypt depth (p < 0.05), fewer goblet cells (p < 0.05), and more inflammatory factor infiltration. In addition, differentially expressed genes (DEGs) were mainly enriched in B-cell immunity and glucose metabolism, and LG piglets had lower concentrations of SCFAs, especially butyrate and isobutyrate (p < 0.05). Finally, most of the significantly differentially abundant microbes were fewer in LG piglets, which affected DEG expressions and SCFA concentrations further resulting in worse energy metabolism and immunity. In conclusion, colonic disrupted microbiota may cause worse glucose metabolism, immunity, and SCFA production in LG piglets, and beneficial microbes colonized in SG piglets may benefit these harmful changes.
Phylogeny, Taxonomy and Morphological Characteristics of Apiospora (Amphisphaeriales, Apiosporaceae)
Authors: Ai Congcong , Dong Zixu , Yun Jingxuan , Zhang Zhaoxue , Xia Jiwen , Zhang Xiuguo
Published: July 2024

Apiospora is widely distributed throughout the world, and usually identified as endophytes, pathogens or saprobes. In this study, six strains were isolated from Bambusaceae sp., Prunus armeniaca, Salix babylonica and saprophytic leaves in Shandong Province, China. Three new species were identified based on a multi-locus gene phylogenetic analysis using a combined dataset of ITS, LSU, TEF1α and TUB2 in conjunction with morphological assessments. Apiospora armeniaca sp. nov., Apiospora babylonica sp. nov., and Apiospora jinanensis sp. nov. have been comprehensively described and illustrated, representing significant additions to the existing taxonomy.
Epidemiological, Pathological, and Molecular Studies on Sheeppox Disease Outbreaks in Karnataka, India
Authors: Manjunatha Reddy Gundallahalli Bayyappa , Krishnappa Varun Kumar , Siddalingaiah Chandan Dypasandra , Rao Suguna , Nayakvadi Shivasharanappa , Harlipura Basavarajappa Chethan Kumar , Gualti Baldev Raj
Published: July 2024

An epidemiological study spanning twelve years has revealed that sheeppox disease is both widespread and endemic, predominantly surging during the winter and summer seasons. This investigation focused on sheeppox across 11 field outbreaks, involving 889 animals from non-migratory flocks across six districts in Karnataka, in the southern peninsula of India. Among these, 105 animals exhibited clinical signs suggestive of sheeppox, such as lesions on the body, and 95 cases were confirmed through PCR testing. The overall positivity rate for sheeppox stood at 10.68% (95 out of 889 animals). The incidence of sheeppox was notably higher in animals aged between 1 and 2 years and was more prevalent in females. Affected animals displayed symptoms including respiratory distress, weakness, fever, loss of appetite, depression, and various skin lesions ranging from papular to pock lesions across their bodies. There was a significant increase in total leukocyte count, while hemoglobin levels, red blood cell counts, and hematocrit values significantly decreased. On gross examination, sheeppox lesions, varying from vesicular to nodular forms, were predominantly found on hairless areas of the body. Microscopic examination of skin lesions revealed extensive changes, such as hyperkeratosis, parakeratosis, acanthosis, hydropic degeneration, and necrosis of epithelial cells, along with characteristic intracytoplasmic viral inclusions. The lungs exhibited type-II pneumocyte hyperplasia and proliferative bronchiolitis, also with intracytoplasmic inclusions. Confirmation of the sheeppox virus was achieved through PCR and subsequent sequence analysis. Phylogenetic analysis of the full-length P32 and RPO30 gene demonstrated homology with sheeppox isolates from various parts of India and neighboring countries, indicating that Indian sheeppox viruses are highly lineage-specific and correlate with the host of origin. Based on these findings, it is recommended to implement a homologous vaccination strategy, utilizing selective host/viral strains to enhance protection in susceptible animals.
Optimizing the Catalytic Performance of Ba1−xCexMnO3 and Ba1−xLaxCu0.3Mn0.7O3 Perovskites for Soot Oxidation in Simulated GDI Exhaust Conditions
Authors: Ghezali Nawel , Díaz-Verde Álvaro , Illán-Gómez María José
Published: July 2024

Ba1−xCexMnO3 (BM-Cex) and Ba1−xLaxMn0.7Cu0.3O3 (BMC-Lax) perovskite-type mixed oxides were synthesized using the sol–gel method adapted for aqueous media with different values of x (0, 0.1, 0.3, 0.6) to estimate the effect of the degree of the partial substitution of Ba by Ce or La on the structure and properties that are relevant for their use as catalysts for gasoline direct injection (GDI) soot oxidation. The samples were deeply characterized by ICP-OES, XRD, XPS, N2 adsorption, H2-TPR, and O2-TPD, and their potential as catalysts for soot oxidation has been analyzed in various scenarios that replicate the exhaust conditions of a GDI engine. By comparing the catalytic performance for soot oxidation of the two tested series (BM-Cex and BMC-Lax) and in the two conditions used (100% He and 1% O2 in He), it could be concluded that (i) in the absence of oxygen in the reaction atmosphere (100% He), BMC-La0.1 is the best catalyst, as copper is also able to catalyze the soot oxidation; and (ii) if oxygen is present in the reaction atmosphere (1% O2/He), BM-Ce0.1 is the most-active catalyst as it presents a higher proportion of Mn(IV) than BMC-La0.1. Thus, it seems that the addition of an amount of Ce or La higher than that corresponding to x = 0.1 in Ba1−xCexMnO3 and Ba1−xLaxCu0.3Mn0.7O3 does not allow us to improve the catalytic performance of BM-Ce0.1 and BMC-La0.1 for soot oxidation in the tested conditions.
Optimization of HS-SPME/GC-MS Method for Determining Volatile Organic Compounds and Sensory Profile in Cocoa Honey from Different Cocoa Varieties (Theobroma cacao L.)
Authors: Nascimento Manuela B. , Amorim Lívia R. , Nonato Marcos A. S. , Roselino Mariana N. , Santana Ligia R. R. , Ferreira Adriana C. R. , Rodrigues Frederico M. , Mesquita Paulo R. R. , Soares Sergio E.
Published: July 2024

This study aimed to develop an analytical method using HS-SPME/GC-MS to determine the volatile organic compound (VOC) profiles and evaluate the sensory attributes of cocoa honey from four cocoa varieties (CCN51, PS1319, SJ02, and Parazinho). Using a multivariate factorial experimental design, the HS-SPME/GC-MS method was optimized to determine the VOC profiles. Twenty previously trained tasters participated in the ranking descriptive analysis, while 108 consumers participated in the acceptance and purchase intention tests. A total of 84 volatile organic compounds were identified from various chemical classes, including acids, alcohols, aldehydes, esters, ketones, monoterpenes, oxygenated monoterpenoids, sesquiterpenes, and oxygenated sesquiterpenoids. Palmitic acid was the compound found in the highest concentration in all varieties (5.13–13.10%). Multivariate analysis tools identified key compounds for differentiation and grouping of the samples. The results revealed that the variety significantly influenced both the VOCs’ concentrations and sensory profiles. The CCN51, PS1319, and SJ02 varieties exhibited the highest diversity of VOCs and sensory attributes. Notably, the SJ02 and CCN51 varieties demonstrated superior acceptability and purchase intention, with means ranging from 7.21 and 7.08 to 3.71 and 3.56, respectively. These results indicate their potential as promising sources of cocoa honey for the food industry.
Hetero-Diels–Alder and CuAAC Click Reactions for Fluorine-18 Labeling of Peptides: Automation and Comparative Study of the Two Methods
Authors: Maujean Timothé , Ramanoudjame Sridévi M. , Riché Stéphanie , Le Guen Clothilde , Boisson Frédéric , Muller Sylviane , Bonnet Dominique , Gulea Mihaela , Marchand Patrice
Published: July 2024

Radiolabeled peptides are valuable tools for diagnosis or therapies; they are often radiofluorinated using an indirect approach based on an F-18 prosthetic group. Herein, we are reporting our results on the F-18 radiolabeling of three peptides using two different methods based on click reactions. The first one used the well-known CuAAC reaction, and the second one is based on our recently reported hetero-Diels–Alder (HDA) using a dithioesters (thia-Diels–Alder) reaction. Both methods have been automated, and the 18F-peptides were obtained in similar yields and synthesis time (37–39% decay corrected yields by both methods in 120–140 min). However, to obtain similar yields, the CuAAC needs a large amount of copper along with many additives, while the HDA is a catalyst and metal-free reaction necessitating only an appropriate ratio of water/ethanol. The HDA can therefore be considered as a minimalist method offering easy access to fluorine-18 labeled peptides and making it a valuable additional tool for the indirect and site-specific labeling of peptides or biomolecules.
The Role of Quercetin as a Plant-Derived Bioactive Agent in Preventive Medicine and Treatment in Skin Disorders
Authors: Zaborowski Michał Kazimierz , Długosz Anna , Błaszak Błażej , Szulc Joanna , Leis Kamil
Published: July 2024

Quercetin, a bioactive plant flavonoid, is an antioxidant, and as such it exhibits numerous beneficial properties including anti-inflammatory, antiallergic, antibacterial and antiviral activity. It occurs naturally in fruit and vegetables such as apples, blueberries, cranberries, lettuce, and is present in plant waste such as onion peel or grape pomace which constitute good sources of quercetin for technological or pharmaceutical purposes. The presented study focuses on the role of quercetin in prevention and treatment of dermatological diseases analyzing its effect at a molecular level, its signal transduction and metabolism. Presented aspects of quercetin potential for skin treatment include protection against aging and UV radiation, stimulation of wound healing, reduction in melanogenesis, and prevention of skin oxidation. The article discusses quercetin sources (plant waste products included), methods of its medical administration, and perspectives for its further use in dermatology and diet therapy.
High-Performance One-Dimensional Sub-5 nm Transistors Based on Poly(p-phenylene ethynylene) Molecular Wires
Authors: Chen Zhilin , Tan Xingyi , Li Qiang , Wan Jing , Xu Gang
Published: July 2024

Poly(p-phenylene ethynylene) (PPE) molecular wires are one-dimensional materials with distinctive properties and can be applied in electronic devices. Here, the approach called first-principles quantum transport is utilized to investigate the PPE molecular wire field-effect transistor (FET) efficiency limit through the geometry of the gate-all-around (GAA) instrument. It is observed that the n-type GAA PPE molecular wire FETs with a suitable gate length (Lg = 5 nm) and underlap (UL = 1, 2, 3 nm) can gratify the on-state current (Ion), power dissipation (PDP), and delay period (τ) concerning the conditions in 2028 to achieve the higher performance (HP) request of the International Roadmap for Device and Systems (IRDS, 2022 version). In contrast, the p-type GAA PPE molecular wire FETs with Lg = 5, 3 nm, and UL of 1, 2, 3 nm could gratify the Ion, PDP, and τ concerning the 2028 needs to achieve the HP request of the IRDS in 2022, while Lg = 5 and UL = 3 nm could meet the Ion and τ concerning the 2028 needs to achieve the LP request of the IRDS in 2022. More importantly, this is the first one-dimensional carbon-based ambipolar FET. Therefore, the GAA PPE molecular wire FETs could be a latent choice to downscale Moore’s law to 3 nm.
Film Coating of Phosphorylated Mandua Starch on Matrix Tablets for pH-Sensitive Release of Mesalamine
Authors: Malik Mayank Kumar , Kumar Vipin , Kumarasamy Vinoth , Singh Om Prakash , Kumar Mukesh , Dixit Raghav , Subramaniyan Vetriselvan , Singh Jaspal
Published: July 2024

Chemically modified mandua starch was successfully synthesized and applied to coat mesalamine-loaded matrix tablets. The coating material was an aqueous dispersion of mandua starch modified by sodium trimetaphosphate and sodium tripolyphosphate. To investigate the colon-targeting release competence, chemically modified mandua starch film-coated mesalamine tablets were produced using the wet granulation method followed by dip coating. The effect of the coating on the colon-targeted release of the resultant delivery system was inspected in healthy human volunteers and rabbits using roentgenography. The results show that drug release was controlled when the coating level was 10% w/w. The release percentage in the upper gastric phase (pH 1.2, simulated gastric fluid) was less than 6% and reached up to 59.51% w/w after 14 h in simulated colonic fluid. In addition to in vivo roentgenographic studies in healthy rabbits, human volunteer studies proved the colon targeting efficiency of the formulation. These results clearly demonstrated that chemically modified mandua starch has high effectiveness as a novel aqueous coating material for controlled release or colon targeting.
Interrelationship between Altered Left Ventricular Ejection Fraction and Nutritional Status in the Post-Acute Myocardial Infarction Patient
Authors: Czinege Maria Gențiana , Nyulas Victoria , Halațiu Vasile Bogdan , Țolescu Constantin , Cojocariu Liliana-Oana , Popa Teodora , Nyulas Tiberiu , Benedek Theodora
Published: July 2024

There is currently little research on the effects of reduced left ventricular ejection fraction and altered nutritional status in patients with acute myocardial infarction. We therefore examined the interrelationship between the parameters of left ventricular dysfunction after acute myocardial infarction and changes in the Geriatric Nutrition Risk Index (GNRI) and the Nutrition Status Control Index (CONUT). Based on the evidence, frailty is considered to be an important factor affecting the prognosis of cardiovascular disease, so it is important to detect malnutrition early to prevent adverse cardiovascular events. This study was an observational, prospective study that included a total of 73 subjects who presented at the 3-month AMI follow-up. All subjects were subjected to laboratory tests and the groups were divided as follows: group 1, in which we calculated the CONUT score, (CONUT < 3 points, n = 57) patients with normal nutritional status and patients with moderate to severe nutritional deficiency (CONUT ≥ 3, n = 16). In group 2, the GNRI score was calculated and out of the 73 patients we had: GNRI ≥ 98, n = 50, patients with normal nutritional status, and GNRI < 98, n = 23, patients with altered nutritional status. The results of this study showed that we had significant differences between LVEF values at 3 months post-infarction where, in the CONUT group, patients with altered nutritional status had lower LVEF values (46.63 ± 3.27% versus 42.94 ± 2.54%, p < 0.001) compared to CONUT < 3. Also, in the GNRI group, we had lower LVEF values in patients with impaired nutritional status (46.48 ± 3.35% versus 44.39 ± 3.35%, p = 0.01). It can be seen that LVEF values are improved at 3 months post infarction in both groups, in patients with impaired nutritional status and in patients with good nutritional status. Patients with impaired nutritional status have lower ejection fraction and worse outcomes in both the CONUT and GNRI groups at 3 months post acute myocardial infarction.
The Effectiveness of Nutritional Interventions Implemented through Lady Health Workers on the Reduction of Stunting in Children under 5 in Pakistan: The Difference-in-Difference Analysis
Authors: Ashraf Khizar , Huda Tanvir M. , Ikram Javeria , Ariff Shabina , Sajid Muhammad , Khan Gul Nawaz , Umer Muhammad , Ahmed Imran , Dibley Michael J. , Soofi Sajid Bashir
Published: July 2024

In Pakistan, the 2018 National Nutrition Survey reported that 40% of children under five years old were stunted. This study assessed the effectiveness of nutritional supplementation in reducing stunting among children under five years old in two rural districts in Sindh, Pakistan. This was a mixed-method quasi-experimental study comprising intervention and control populations, with 3397 and 3277 children under five years old participating in the baseline and end-line surveys, respectively. The study areas were similar in terms of demographic and economic circumstances. In the intervention group, pregnant and lactating women (first six months post-partum) received wheat soy blend, children 6–23 months old received Wawamum (lipid-based supplement), and children 24–59 months old received micronutrient powders, all through lady health workers. This was underpinned by nutrition behaviour change communication for appropriate complementary feeding practices and hygiene promotion targeted at primary caregivers. The control group received no intervention. The impact was assessed using the difference-in-difference analysis with kernel propensity score matching to adjust the differences among the control and intervention populations. The overall DID analysis indicated that the intervention did not significantly reduce the prevalence of stunting (under 5 years) [DID = −5.1, p = 0.079]. The adjusted DID indicated a significant decrease of 13% [DID = −13.0, p = 0.001] in the number of stunted children 24–59 months of age at the endline survey. A significant reduction in underweight among children 24–59 months old was also observed (DID = −9.4%, p = 0.014). In conclusion, this evidence further establishes that nutrient uptake through an intervention for a short duration cannot effectively reduce stunting. It requires continuous nutritional supplementation for mothers during the pregnancy and an initial six months of lactation and then nutritional supplementation for children 6–59 months of age underpinned by effective behaviour change communication targeting mothers and other caregivers for improving complementary feeding practices and hygiene promotion.
Antihypertensive Potential of Pistacia lentiscus var. Chia: Molecular Insights and Therapeutic Implications
Authors: Efentakis Panagiotis , Symeonidi Lydia , Gianniou Despoina D. , Mikropoulou Eleni V. , Giardoglou Panagiota , Valakos Dimitrios , Vatsellas Giannis , Tsota Maria , Kostomitsopoulos Nikolaos , Smyrnioudis Ilias , Trougakos Ioannis P. , Halabalaki Maria , Dedoussis Georgios V. , Andreadou Ioanna
Published: July 2024

Background: Hypertension poses a significant global health burden and is associated with cardiovascular morbidity. Chios mastic gum (CMG), derived from Pistacia lentiscus var. Chia, shows potential as a phytotherapeutic agent, due to its multifaceted beneficial effects. However, its anti-hypertensive effects and vascular, circulatory, and renal-related dysfunction, have not been thoroughly investigated. Herein, we aimed to explore the antihypertensive potential of CMG, focusing on vascular and renal endothelium, in vivo. Methods: Two models of hypertension in male rats, induced by Angiotensin II and Deoxycorticosterone acetate (DOCA)–high-salt administration, were utilized. CMG was administered at 220 mg/kg daily for four weeks after hypertension onset and blood pressure was measured non-invasively. Whole blood RNA sequencing, metabolomics, real-time PCR, and Western blot analyses of kidney and aorta tissues were additionally performed. Results: CMG significantly lowered systolic, diastolic, and mean blood pressure in both models. RNA sequencing revealed that CMG modulated immunity in the Angiotensin II model and metabolism in the DOCA–HS model. CMG downregulated genes related to oxidative stress and endothelial dysfunction and upregulated endothelial markers such as Vegfa. Metabolomic analysis indicated improved endothelial homeostasis via lysophosphatidylinositol upregulation. Conclusions: CMG emerges as a potent natural antihypertensive therapy, demonstrating beneficial effects on blood pressure and renal endothelial function.
Rupture Test: A New Method for Evaluating Maize (Zea mays) Seed Vigour
Authors: Li Heqin , Yue Haiwang , Lu Miaomiao , Jia Ru , Jiang Xuwen
Published: July 2024

To explore the application of seed germination biomechanical event(s) in seed vigour tests, a new procedure for the evaluation of maize seed vigour tests based on pericarp–testa rupture (PR) and coleorhiza rupture (CR) during seed germination was developed. Twenty–four lots of hybrid maize were used to determine the feasibility of the rupture test (RT) as a seed vigour test in Zea mays. The results showed that the physiological quality pattern of 24 maize seed lots assessed through RT was similar to that obtained through analysis with other seed test methods. Correlation and regression analyses revealed that the percentage of CR and percentage of PR + CR at “15 ± 0.5 °C for 120 h ± 1 h” and “20 ± 0.5 °C for 72 h ± 15 min” exhibited positive correlations with the field seedling emergence data (p < 0.01). Hence, the proposed method (the rupture test) is cogent and effective, thus providing an important reference for more crops to select for seed germination event(s) and establishing corresponding new methods for seed vigour tests in the future.
Overexpression of AcWRKY31 Increases Sensitivity to Salt and Drought and Improves Tolerance to Mealybugs in Pineapple
Authors: Wai Myat Hnin , Luo Tiantian , Priyadarshani S. V. G. N. , Zhou Qiao , Mohammadi Mohammad Aqa , Cheng Han , Aslam Mohammad , Liu Chang , Chai Gaifeng , Huang Dongping , Liu Yanhui , Cai Hanyang , Wang Xiaomei , Qin Yuan , Wang Lulu
Published: July 2024

Pineapple is a globally significant tropical fruit, but its cultivation faces numerous challenges due to abiotic and biotic stresses, affecting its quality and quantity. WRKY transcription factors are known regulators of stress responses, however, their specific functions in pineapple are not fully understood. This study investigates the role of AcWRKY31 by overexpressing it in pineapple and Arabidopsis. Transgenic pineapple lines were obtained using Agrobacterium-mediated transformation methods and abiotic and biotic stress treatments. Transgenic AcWRKY31-OE pineapple plants showed an increased sensitivity to salt and drought stress and an increased resistance to biotic stress from pineapple mealybugs compared to that of WT plants. Similar experiments in AcWRKY31-OE, AtWRKY53-OE, and the Arabidopsis Atwrky53 mutant were performed and consistently confirmed these findings. A comparative transcriptomic analysis revealed 5357 upregulated genes in AcWRKY31-OE pineapple, with 30 genes related to disease and pathogen response. Notably, 18 of these genes contained a W-box sequence in their promoter region. A KEGG analysis of RNA-Seq data showed that upregulated DEG genes are mostly involved in translation, protein kinases, peptidases and inhibitors, membrane trafficking, folding, sorting, and degradation, while the downregulated genes are involved in metabolism, protein families, signaling, and cellular processes. RT-qPCR assays of selected genes confirmed the transcriptomic results. In summary, the AcWRKY31 gene is promising for the improvement of stress responses in pineapple, and it could be a valuable tool for plant breeders to develop stress-tolerant crops in the future.
Analyzing Spatio-Temporal Dynamics of Grassland Resilience and Influencing Factors in the West Songnen Plain, China, for Eco-Restoration
Authors: Wang Gefei , Shi Zhenyu , Wen Huiqing , Bo Yansu , Li Haoming , Li Xiaoyan
Published: July 2024

Grassland plays an indispensable role in the stability and development of terrestrial ecosystems. Quantitatively assessing grassland resilience is of great significance for conducting research on grassland ecosystems. However, the quantitative measurement of resilience is difficult, and research on the spatio-temporal variation of grassland resilience remains incomplete. Utilizing the Global Land Surface Satellite (GLASS) leaf area index (LAI) product derived from MODIS remote sensing data, along with land cover and meteorological data, this paper constructed the grassland resilience index (GRI) in the west Songnen Plain, China, a typical region with salt and alkali soils. This paper analyzed the spatio-temporal changes of the GRI and explored the contribution of climate factors, human activities, and geographical factors to the GRI. The results revealed that from 2000 to 2021, the GRI in the study area ranged from 0.1 to 0.22, with a multi-year average of 0.14. The average GRI exhibited a pattern of high-value aggregations in the north and low-value distributions in the south. Trend analysis indicated that areas with an improved GRI accounted for 59.09% of the total grassland area, but there were still some areas with serious degradation. From 2000 to 2015, the latitude and mean annual temperature (MAT) were principal factors to control the distribution of the GRI. In 2020, the mean annual precipitation (MAP) and MAT played important roles in the distribution of the GRI. From 2000 to 2021, the influence of human activities was consistently less significant compared to geographical location and climate variables.
Integrating Proteomics and Metabolomics Approaches to Elucidate the Mechanism of Responses to Combined Stress in the Bell Pepper (Capsicum annuum)
Authors: Morales-Merida Brandon Estefano , Grimaldi-Olivas Jesús Christian , Cruz-Mendívil Abraham , Villicaña Claudia , Valdez-Torres José Benigno , Heredia J. Basilio , León-Chan Rubén Gerardo , Lightbourn-Rojas Luis Alberto , Monribot-Villanueva Juan L. , Guerrero-Analco José A. , Ruiz-May Eliel , León-Félix Josefina
Published: July 2024

Bell pepper plants are sensitive to environmental changes and are significantly affected by abiotic factors such as UV-B radiation and cold, which reduce their yield and production. Various approaches, including omics data integration, have been employed to understand the mechanisms by which this crop copes with abiotic stress. This study aimed to find metabolic changes in bell pepper stems caused by UV-B radiation and cold by integrating omic data. Proteome and metabolome profiles were generated using liquid chromatography coupled with mass spectrometry, and data integration was performed in the plant metabolic pathway database. The combined stress of UV-B and cold induced the accumulation of proteins related to photosynthesis, mitochondrial electron transport, and a response to a stimulus. Further, the production of flavonoids and their glycosides, as well as affecting carbon metabolism, tetrapyrrole, and scopolamine pathways, were identified. We have made the first metabolic regulatory network map showing how bell pepper stems respond to cold and UV-B stress. We did this by looking at changes in proteins and metabolites that help with respiration, photosynthesis, and the buildup of photoprotective and antioxidant compounds.
Anti-Microbial, Thermal, Mechanical, and Gas Barrier Properties of Linear Low-Density Polyethylene Extrusion Blow-Molded Bottles
Authors: Alkarri Saleh , Naveed Muhammed , Alali Fatimah , Vachon Jérôme , Walworth Aaron , Vanderberg Abigail
Published: July 2024

Microbial contamination can occur on the surfaces of blow-molded bottles, necessitating the development and application of effective anti-microbial treatments to mitigate the hazards associated with microbial growth. In this study, new methods of incorporating anti-microbial particles into linear low-density polyethylene (LLDPE) extrusion blow-molded bottles were developed. The anti-microbial particles were thermally embossed on the external surface of the bottle through two particle deposition approaches (spray and powder) over the mold cavity. The produced bottles were studied for their thermal, mechanical, gas barrier, and anti-microbial properties. Both deposition approaches indicated a significant enhancement in anti-microbial activity, as well as barrier properties, while maintaining thermal and mechanical performance. Considering both the effect of anti-microbial agents and variations in tensile bar weight and thickness, the statistical analysis of the mechanical properties showed that applying the anti-microbial agents had no significant influence on the tensile properties of the blow-molded bottles. The external fixation of the particles over the surface of the bottles would result in optimum anti-microbial activity, making it a cost-effective solution compared to conventional compounding processing.
Failure Characteristics and Cooperative Control Strategies for Gob-Side Entry Driving near an Advancing Working Face: A Case Study
Authors: Wu Wenda , Wang Tianchen , Bai Jianbiao , Liu Jinhu , Wang Xiangyu , Xu Haiyun , Feng Guorui
Published: July 2024

Gob-side entry driving near an advancing working face can improve the recovery rate of coal resources and keep the balance between mining and development. However, the large displacement of the gob-side entry caused by the mining dynamics of abutment pressure challenges the safety and processes of coal mining. This article takes the 15102 tailentry of Xizhang Coal Mine in Changzhi City, Shanxi Province, as an example to study the stability of the coal pillar and the failure characteristics of the surrounding rock and proposes cooperative control strategies of surrounding rock stability. Field tests indicated that when the coal pillar width was 15 m, the displacements of the entry floor, roof, coal pillar side, and solid coal side were 1121 mm, 601 mm, 783 mm, and 237 mm, respectively. A meticulously validated numerical model, incorporating a double-yield model for the gob materials and calibrated parameters, was developed to investigate the stress changes and yield zone distribution across the coal pillar with different sizes. The results of the simulation indicate that the influence range of the dynamic abutment pressure caused by mining in the upper section of gob-side entry driving is 30 m ahead and 70 m behind. When the coal pillar width increases from 7 m to 20 m, the internal stress of the coal pillar increases continuously, while the internal stress of the solid coal decreases continuously. It is estimated that the reasonable coal pillar width should be 7 m, which is subjected to a lower load. The cooperative control strategies comprising a narrow coal pillar, hydraulic fracturing roof cutting for pressure relief, and entry dynamic support were proposed and applied in the 15103 tailentry. The final displacements of the floor, roof, coal pillar side, and solid coal side were 66.01%, 62.06%, 61.05%, and 63.30% lower than that of the 15102 tailentry in the same period, respectively, which effectively controlled the stability of surrounding rock. In addition, this finding for the gob-side entry driving near an advancing working face in this study can potentially be applied to other similar projects.
Geochemical Characteristics and Hydrocarbon Generation Potential of Coal-Measure Source Rocks in Julu Sag
Authors: Wang Yang , Zhang Hanyu , Yang Liu , Zhu Yanming , Chang Zhixiang
Published: July 2024

To uncover the reservoir characteristics and enrichment law of coal-measure gas in Julu sag, Hebei Province, and achieve co-exploration and co-mining, it is necessary to conduct a comprehensive analysis. In this study, we investigated the characteristics of coal-measure gas accumulation in the Taiyuan Formation and Shanxi Formation in the Julu area. This was achieved by collecting data on coal-measure source rocks and organic geochemistry, which were then combined with regional geological conditions. This study indicates that the coal seams and shales of Shanxi Formation and Taiyuan Formation in the study area serve as the primary source rocks. The predominant macerals found in coal rock are vitrinite. Furthermore, the organic matter type present in shale is primarily categorized as type II2, with the organic matter maturity falling within the immature–mature stage. Based on the simulation results of tectonic-burial history, thermal evolution history, and hydrocarbon generation history in the study area, it is evident that the coal-measure source rocks experienced their first peak of hydrocarbon generation during the Mesozoic era as a result of deep metamorphism. Subsequently, the area experienced uplift and erosion, leading to the release of coal-bearing natural gas. Since the Paleogene period, the coal-bearing source rocks have undergone sedimentary burial and entered the secondary hydrocarbon generation stage, resulting in significant production of oil and gas. Based on the analysis of gas content, buried depth, source rock thickness, and sealing conditions in the study area, it is evident that the potential of coal-measure gas resources in the study area is primarily comprised of shale gas with supplementary coalbed methane. It can be inferred that the deeper areas within the study area hold greater exploration prospects.