bluuebunny/crossref_metadata_2025 huggingface dataset:
Ceratoconjuntivite seca e melanose corneal em cão: Relato de caso
Authors: Santos Emanuele Soares dos , Oliveira Karina de Camargo , Carniel Leandro Vinícius , Rodrigues Denise de Fátima
Published: December 2022

A ceratoconjuntivite seca, também conhecida como olho seco, é uma doença de rotina clínica na oftalmologia veterinária; é caracterizada pela diminuição da parte aquosa do filme lacrimal e por complicações da saúde ocular devido ao ressecamento da córnea. A ceratoconjuntivite seca é uma afecção sem cura, mas existem tratamentos de acordo com o quadro, que pode ser agudo, intermediário ou crônico. O diagnóstico precoce com tratamento adequado colabora para um prognóstico favorável. O presente estudo relata um caso de ceratoconjuntivite seca em cão da raça Pug, macho, três anos, que apresentava secreção mucopurulenta bilateral e opacidade da córnea. No exame ocular, foram observadas hiperpigmentação da córnea e opacidade corneal bilateral, cílios ectópicos bilaterais, sem a presença de prurido, incômodo ou deficiência visual. Para o diagnóstico, foi utilizado o teste com colírio a base de fluoresceína para avaliar a integridade do epitélio córneo-conjuntival, a tonometria, exame que avalia a pressão intraocular, e o teste de Schirmer bilateral, que tem como objetivo avaliar a produção lacrimal. Após os resultados, o cão foi diagnosticado com ceratoconjuntivite seca e melanose corneal. Como tratamento, foi instituída terapia tópica com pomada de tacrolimus a 0,04%, aplicada sobre as pálpebras uma vez ao dia por 6 meses. Foi observada uma resposta significativa na produção lagrimal e a melanose foi estabilizada e reduzida com o tratamento tópico, não sendo necessária intervenção cirúrgica.
Avaliação da ação antimicrobiana da própolis comercial
Authors: Pereira Luana Gomes , Medeiros Margareti
Published: December 2022

O objetivo do presente artigo foi avaliar se a própolis comercial é eficiente em inibir o crescimento bacteriano in vitro das bactérias Staphylococcus aureus e Salmonella Typhimurium, sendo que o delineamento experimental constituído por esquema fatorial foi de 2 (dias) x 2 (bactérias) x 4 (marcas de própolis comerciais) x 8 (distribuição das própolis comerciais nas placas). Com os resultados demostrou-se ausência de halo de inibição em todas as placas de petri avaliadas das quatro marcas comerciais de própolis. Concluindo-se que, para a metodologia a qual foi aplicada o resultado do experimento apresentou-se insatisfatório. Contudo, diversos outros autores encontraram potencial antimicrobiano sendo que a grande maioria utilizou a própolis bruta em distintas concentrações, logo é essencial realizar mais estudos aprofundados além disso, a referida temática possui grande relevância perante o risco iminente diante de uma resistência antimicrobiana.
Giardíase em cães e gatos, uma emergência em saúde única: Revisão
Authors: Beltrão Marina Soares , Silva Vera Lúcia Dias da , Souza Cleusely Matias de , Santos Thalita de Castro Carvalho , Moraes Iago de Sá
Published: December 2022

A Giardíase é uma infecção causada pelo protozoário Giárdia spp., que é adquirido por transmissão direta ou indireta, sendo de maior importância a via hídrica. É considerada uma das zoonoses mais importantes na rotina clínica veterinária, com ampla distribuição mundial e considerável prevalência no Brasil, sendo bastante relevante para a saúde única. A principal espécie que acomete os animais domésticos é a Giárdia duodenalis. Ela causa alterações no intestino delgado, provocando atrofia das vilosidades e aprofundamento das cristas e afetando a absorção de nutrientes. Em virtude de sua ação intestinal, promove diarreia intensa, a qual leva à severa desidratação, podendo causar a morte em animais jovens, se não tratada adequadamente. O diagnóstico é feito através dos exames de fezes dos animais suspeitos da infecção. A profilaxia consiste em executar uma higienização adequada do ambiente em que cães e gatos residem, e ter bons hábitos de higiene, como lavar bem as mãos. O presente trabalho tem por objetivo realizar uma revisão de literatura sobre a giardíase, descrevendo sua etiologia, aspectos epidemiológicos, patogenia, sinais clínicos, formas de diagnóstico, tratamento, prognóstico, medidas de prevenção e controle, e aspectos importantes em saúde pública. Para tanto, foi realizado um levantamento bibliográfico nas bases de dados do PubMed, Scielo e Google Scholar, entre os anos de 2010 a 2022. Foram utilizados os seguintes descritores: giardíase, cães, gatos, epidemiologia, diagnóstico, saúde pública e zoonose. Alguns trabalhos em diversas regiões do Brasil foram estudados e foi verificado que a prevalência para Giárdia spp. variou de 0,58 a 50% para cães, e em gatos os percentuais foram entre 0,6 à 60%, cabendo ressaltar, que o interstício das diferenças pode ser decorrente das diferentes amostragens consideradas nos estudos. A realidade encontrada no Brasil, neste estudo, provavelmente está subestimada, já que não há notificação compulsória. Assim, os números de casos deixam de aparecer nos boletins epidemiológicos de toda rede de saúde única do Brasil, e dificultam a análise da real situação em saúde da nação.
KRYZYS KLIMATYCZNY W DOŚWIADCZENIU INDYWIDUALNYM
Authors: Tucholska Kinga , Gulla Bożena
Published: December 2022

Celem artykułu jest przedstawienie aktualnego stanu wiedzy na temat spektrum ludzkich reakcji poznawczych, afektywnych oraz wyrażonych behawioralnie w obliczu kryzysu klimatycznego. Różnorodność postaw wobec zmian klimatu i stopień zaangażowania w działania, by tym zmianom przeciwdziałać, wynika z poziomu wiedzy i przekonań na temat aktualnej sytuacji, w tym stopnia wiary w mity klimatyczne. Konsekwencją świadomości niebezpieczeństwa, jakie stanowi postępujący kryzys ekologiczno-klimatyczny, jest nasilenie trudnych emocji i złożonych stanów uczuciowych, takich jak solastalgia, depresja klimatyczna czy ekożałoba. W odniesieniu do tej wiedzy wskazano, w jaki sposób można zapobiegać doświadczaniu kryzysu klimatycznego w kategoriach osobistego kryzysu i jak mobilizować do działania w odpowiedzi na wyzwania sytuacji klimatycznej
Peeking Behind the Curtains
Authors: Fratini Annamaria , Hemer Susan R. , Chur-Hansen Anna
Published: December 2022

Patchwork ethnography is a viable methodological and theoretical approach. Fieldwork can be accessible, achievable and accommodating of both personal and professional circumstances and responsibilities of the researcher, and external factors such as living within a COVID-19 world. In this article, we explain patchwork ethnography and showcase how the methodology was implemented during the first author's PhD fieldwork conducted in 2020–2021 relating to peeking behind the physical and metaphorical curtains of the death industry to understand the handling, management and conceptualisation of the dead human body in Adelaide, South Australia. We demonstrate how field sites were constructed and discuss the methodological tools utilised to produce an ethnographic experience. We also question the ongoing viability of notions of ‘traditional’ fieldwork practices.
‘I Certainly Wasn't as Patient-Centred’
Authors: Logan Ryan I.
Published: December 2022

This article explores how a group of paramedics were cross-trained as community health workers (CHWs) in Indiana. Cross-training paramedics as CHWs provided a foundation to better understand the social issues that occur outside of the hospital and clinic, thereby enabling further empathy among paramedics and seeking means to connect patients to other health and social services agencies. I detail how earning a certification as a CHW shifted the mindset of the paramedics and their approach toward caregiving. Ultimately, I argue how cross-training healthcare professionals can further expand the general awareness of CHWs and possible opportunities for employment. However, steps must be taken to ensure that reducing the CHW model to a cross-training opportunity will not minimise the impacts of hiring a full-time CHW.
PENGARUH KECERDASAN EMOSIONAL TERHADAP MOTIVASI BELAJAR SISWA PROGRAM KEAHLIAN AKUNTANSI
Authors: Nuraisyiah Nuraisyiah , Nurjannah Nurjannah , Rijal Abd.
Published: December 2022

Abstrak:Penelitian ini bertujuan untuk mengetahui pengaruh kecerdasan emosional terhadap motivasi belajar siswa program keahlian akuntansi di SMK Negeri 1 Makassar. Populasinya adalah seluruh siswa program keahlian akuntansi SMK Negeri 1 Makassar yang terdiri dari 414 siswa. Teknik pengambilan sampel menggunakan teknik proportionate stratified random sampling dengan sampel sebanyak 80 siswa yang diambil secara acak dan proporsional. Teknik pengumpulan data yang digunakan adalah kuesioner dan dokumentasi. Teknik analisis data yang digunakan adalah uji instrumen yang terdiri atas uji validitas dan uji reliabilitas, uji hipotesis yang terdiri atas analisis regresi linear sederhana, uji t, dan koefisien determinasi. Berdasarkan hasil analisis data yang telah dilakukan maka diperoleh model persamaan regresi linear sederhana = 18,280+0,669X yang berarti tiap penambahan 1 nilai kecerdasan emosional, maka nilai motivasi belajar mengalami kenaikan 0,669. Dari hasil analisis koefisien determinasi (r2) diperoleh nilai r2 = 38,9 % yang berarti kecerdasan emosional memiliki kontribusi terhadap motivasi belajar sebesar 38,9% dan sisanya 61,1% dipengaruhi oleh factor lain. Sementara dari hasil analisis uji-t diperoleh nilai signifikan 0,000<0,05 yang berarti kecerdasan emosional berpengaruh signifikan terhadap motivasi belajar, dengan demikian hipotesis diterima.Abstract:This study aims to determine the effect of emotional intelligence on students' motivation to study accounting skills program at SMK Negeri 1 Makassar. The population is all students of the accounting expertise program at SMK Negeri 1 Makassar which consists of 414 students. The sampling technique used is proportionate stratified random sampling with a sample of 80 students taken randomly and proportionally. Data collection techniques used are questionnaires and documentation. The data analysis technique used is instrument test which consists of validity and reliability test, hypothesis test which consists of simple linear regression analysis, t test, and coefficient of determination. Based on the results of data analysis that has been carried out, it is obtained a simple linear regression equation model Y = 18.280 + 0.669X, which means that for each addition of 1 emotional intelligence value, the value of learning motivation increases by 0.669. From the analysis of the coefficient of determination (r2), the value of r2 = 38.9% means that emotional intelligence has a contribution to learning motivation of 38.9% and the remaining 61.1% is influenced by other factors. Meanwhile, the results of the t-test analysis obtained a significant value of 0.000<0.05, which means that emotional intelligence has a significant effect on learning motivation, thus the hypothesis is accepted
MUHAMMADIYAH AND PROGRESSIVE EFFORTS FOR THE RIGHTS OF CHILDREN WITH SPECIAL NEEDS
Authors: Nurismawan Ach. Sudrajad , Fahruni Findivia Egga , Sartinah Endang Pudjiastuti , Purwoko Budi
Published: December 2022

Abstrak: Jumlah kajian ilmiah terkait kontribusi nyata Muhammadiyah di bidang pendidikan sangatlah berlimpah. Akan tetapi, dalam konteks kontribusi Muhammadiyah di bidang pendidikan khusus/inklusif masih sangatlah minim, padahal dalam beberapa tahun belakangan lembaga pendidikan Muhammadiyah sangatlah progresif untuk memfasilitasi hal ini. Karena itu tulisan ini bertujuan untuk 1) mendeskripsikan upaya-upaya progresif Muhammadiyah di bidang pendidikan inklusif; 2) Menganalisis peluang dan tantangan pendidikan inklusi di sekolah Muhammadiyah, dan 3) Memberikan beberapa rekomendasi yang konstruktif untuk meningkatkan kualitas pendidikan inklusi di sekolah Muhammadiyah. Makalah ini menggunakan metode studi kepustakaan pada sumber-sumber yang relevan seperti jurnal ilmiah, buku, dan berita kemudian dianalisis secara sistematis sesuai kaidah-kaidah ilmiah. Hasil kajian menunjukkan bahwa Muhammadiyah telah banyak berkontribusi dalam pemenuhan hak pendidikan anak berkebutuhan khusus, terutama melalui program pendidikan inklusi di sekolah Muhammadiyah. Temuan penelitian ini dapat dijadikan acuan dan pedoman bagi para pemangku kepentingan dalam mengevaluasi dan mengembangkan kurikulum sumber daya manusia dan pendidikan inklusif di sekolah Muhammadiyah ke arah yang lebih baik.Abstract: The number of scientific studies related to the actual contribution of Muhammadiyah to education is abundant. However, the gift of Muhammadiyah in special/inclusive education is minimal, although, in recent years, Muhammadiyah educational institutions have advanced to facilitate this. Therefore, this paper aims to 1) describe Muhammadiyah's progressive efforts in the field of inclusive education, 2) Analyze the opportunities and challenges of inclusive education in Muhammadiyah schools, and 3) Provide some constructive recommendations to improve the quality of inclusive education in Muhammadiyah schools. This paper uses a literature study method on relevant sources such as scientific journals, books, and news, then analyzed systematically according to scientific principles. The study results show that Muhammadiyah has contributed much to fulfilling the educational rights of children with special needs, primarily through inclusive education programs in Muhammadiyah schools. The findings of this study can be used as a reference and guideline for stakeholders in evaluating and developing a human resource curriculum and inclusive education in Muhammadiyah schools in a better direction.
PENGEMBANGAN E-MODUL GEOMETRI BERBASIS BUDAYA SASAK SEBAGAI SUMBER BELAJAR DARING SISWA SEKOLAH DASAR
Authors: Mariyati Yuni , Hastuti Intan Dwi
Published: December 2022

Abstrak: Tujuan penelitian secara umum adalah untuk mendapatkan e-modul Geometri Berbasis Budaya Sasak. Sedangkan tujuan khususnya untuk mengetahui Bagaimana kevalidan media tersebut digunakan sebagai Sumber Belajar Daring Siswa SD. Desain penelitian ini menggunakan Borg and Gall. Adapun bentuk data yang digunakan merupakan bentuk data kuantitatif yang dilakukan dengan lembar angket validasi. Hasil penelitian menunjukan bahwa: (1) e-modul yang dibuat berupa link berbentuk online mencangkup materi geometri khusus bangun datar persegi, persegi panjang dan segitiga dengan mengeksplorasi unsur geometri pada bangunan adat di desa sade Lombok Tengah (2) e-modul berbasis budaya sasak yang dikembangkan memperoleh data kevalidan dari validator ahli media dan materi, serta praktisi, dengan rata-rata nlai 94%, sehingga dapat disimpulkan bahwa e-modul geometri berbasis budaya sasak yang telah didikembangkan sudah valid dan dapat digunakan siswa sebagai sumber belajar daring.Abstract:The general objective of the research is to obtain an e-module on Geometry Based on Sasak Culture. While the specific purpose is to find out how the validity of the media is used as an online learning resource for elementary school students. This research design uses Borg and Gall. The form of data used is a form of quantitative data which is carried out with a validation questionnaire sheet. The results of the study show that: (1) the e-module made in the form of an online link includes special geometry material for square, rectangular and triangular shapes by exploring the elements of geometric in traditional buildings in the village of Sade, Central Lombok (2) e-modules based on Sasak culture The developed data obtained validity data from media and materials expert validators, as well as practitioners, with an average value of 94%, so it can be concluded that the Sasak culture-based geometry e-module that has been developed is valid and can be used by students as online learning resources.
A BIOASSAY APPROACH TO COMPLEMENT CHEMICAL STANDARDIZATION OF ASHWAGANDHA ROOT EXTRACTS
Authors: Singh Vineet Kumar , Mundkinajeddu Deepak , Koshy Rojison , Bhat Deeksha , Nithin J.  , Balaji K. R. , A.G. Gayathri
Published: December 2022

Withania somnifera (L.) Dunal, popularly known as ashwagandha, is an Indian plant that has long been utilized in Ayurveda for its adaptogenic effects, as evidenced by several clinical and preclinical research publications. Using an in-vitro acetylcholinesterase inhibition assay (AChE), we performed bioassay-guided fractionation of the ethanolic extract of ashwagandha roots. The inhibitory activity was found to be concentrated in the fractions containing withanolides, and the active fractions were purified to yield nine distinct withanolides. Five of these had a considerable inhibitory effect against acetylcholinesterase (IC50 <10 µg/ml), with 12-deoxywithastramonolide being the most active (IC50-1.54 µg/ml). Ashwagandha extracts are typically standardized to the content of withanolides by chromatographic methods like HPLC. We evaluated if acetylcholinesterase inhibition assay can be utilized for biological standardization of commercial batches that can complement the current chromatographic methods. Nine different commercially produced batches of Ashwagandha extracts were evaluated with acetylcholinesterase inhibition in-vitro, HPLC profiling, and quantitative determination of nine withanolides. The IC50 values ranged from 15 µg/ml to 95 µg/ml, while the total content of nine withanolides varied between 2.78%w/w to 3.58%w/w. Given the inherent variability in withanolide content, an acetylcholinesterase inhibition assay can be utilized to enhance quality control of commercially available ashwagandha extracts.
DESIGNING OF STABLE CO-CRYSTALS OF AZITHROMYCIN USING SUITABLE COFORMERS
Authors: Srinivas Poojary Pooja , Prabhu Nishank , SG Vasantharaju , Patel Neel , Pai Aravind , Pai Vasudev , Badamane Sathyanarayana Muddukrishna
Published: December 2022

In this present study, a new co-crystal of azithromycin with nicotinamide and naringenin has been developed with improved solubility. Azithromycin is a class II drug with poor aqueous solubility; hence an attempt has been made to improve its solubility through co-crystallization technology. In this study, the coformers selected were nicotinamide and naringenin based on ease of hydrogen bond formation. The co-crystal of azithromycin with nicotinamide was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The co-crystal of azithromycin with naringenin was prepared in three ratios (1:1, 1:2, and 2:1) by dry grinding and slow solvent evaporation method. The formation of the co-crystal was confirmed by Fourier transform infrared spectroscopy (FTIR), differential scanning calorimetry (DSC), and powder X-ray diffractometry (PXRD). AzithromycinNicotinamide cocrystal 1:1 prepared by the dry grinding method was increased by 6.85 fold as compared to pure drug. Azithromycin-Naringenin cocrystal 1:1 prepared by solvent evaporation method was increased by 3.06 fold as compared to pure drug.
THE USE OF GC-MS AND FTIR SPECTROSCOPY COUPLED WITH MULTIVARIATE ANALYSIS FOR THE DETECTION OF RED GINGER OIL ADULTERATION
Authors: Syafri Suryati , Jaswir Irwandi , Yusof Faridah , Rohman Abdul , Hamidi Dachriyanus
Published: December 2022

The ginger oil traded worldwide could come from various sources. Standard quality is the most critical aspect of ensuring customer safety. This study aims to develop an analytical method for red ginger oil (RGO) authentication. Chemical compositions of red ginger oil were determined by Gas Chromatography-Mass Spectrometry (GC-MS). The Fourier Transform Infrared Spectroscopy (FTIR) coupled with multivariate analysis (discriminant analysis (DA), partial least square (PLS), and principal component regression (PCR) were used to identify and quantify the adulterant. The total terpenoid compounds were 55.72%, with the percentage of monoterpenes at 34.29% and sesquiterpenes at 21.43%. E-Citral (19.01%), Z-Citral (14.82%), Geranyl Acetate (11.90%), Geraniol (9.56%), 1,8-Cineole (5.84%), and camphene (4.92%) were identified as the main constituents. The best PLS model for quantifying the level of palm oil in RGO was at the wavenumber 3100–2700 cm–1, while the region of 3100 – 2700 and 1850 – 650 cm–1 was suitable for detection of soybean adulterants. FTIR spectroscopy coupled with chemometrics produced accurate and fast authentication of red ginger oil without the used solvent. Then, the GC-MS technique could identify the chemical constituents present in the red ginger oil.
BIODEGRADABLE, MORPHOLOGY, AND THERMAL ANALYSIS ON THERMOPLASTIC SAGO (Metroxylon Sagu Rottb.) STARCH/POLYETHYLENE/POLYETHYLENE GRAFTED MALEATE ANHYDRATE
Authors: Riyanto  , S. Hasibuan  , Tanjung D.A. , Z. Noer  , V. Sisca
Published: December 2022

The purpose of this study was to examine the effect of adding polyethylene to thermoplastic sago starch in the presence of a coupling agent (polyethylene grafting maleate anhydrate) on the degradation rate, morphology, thermal gravimetry, and differential thermal analysis. The compound of thermoplastic sago starch/polyethylene/polyethylene grafting Maleic Anhydrous was carried out using the mixing method in an internal mixer. Based on the results of the study, there was a shift in the wave number in the O-H, C-H, and CH2 groups in bioplastic composites. The surface morphology showed that the dispersed phase (Polyethylene) was evenly distributed over the entire surface of the matrix (sago starch). The gravimetric analysis of the thermal curves shows that the thermal degradation occurs in three stages: 2010C, 3500C, and 5000C. The addition of polyethylene can increase the thermal resistance from 3500C to 6000C. It can be seen that there are endothermic and exothermic peaks on the Thermal Differential Analysis curve. The addition of polyethylene resulted in a decrease in the rate of degradation in freshwater, seawater, and soil burial media.
OPTICAL STUDY OF SOL-GEL SPIN-COATING TiO2/Si3N4 MULTILAYERS ON GLASS SUBSTRATES
Authors: Sarvjeet Dubey Raghvendra , Saravanan Sigamani
Published: December 2022

In this work, we have adopted a sol-gel spin-coating technique and prepared alternative TiO2/Si3N4 multilayers on glass substrates. These alternating layers of TiO2/Si3N4 thin film samples were calcinated at two different temperatures and studied for their optical performance. The optical properties of fabricated thin films were investigated by UV-Visible spectrophotometer, X-ray diffractometer (XRD), Fourier transform infrared (FTIR), and Raman spectroscopy. UV-visible spectra showed broader and higher optical reflectance in the visible spectral region. FTIR transmission spectra show Ti-O-Ti and Si-N stretching modes at around 600 and 881 cm-1. XRD pattern confirmed the presence of anatase-TiO2 and α-Si3N4 phases. Finally, Raman spectra revealed the presence of anatase-TiO2 and N-Si vibration modes.
CRUDE PALM OIL GUM AS ADSORBENT TO REDUCE RESEARCH OCTANE NUMBER AND BOILING POINT OF BIOETHANOL FOR GASOHOL E-85
Authors: M. Supeno  , B. Aritonang  , Ritonga A.H. , R. Gurusinga  , K. Harefa  , R. Tambun
Published: December 2022

The mixture of bioethanol with gasoline (gasohol) as vehicle fuel can increase the research octane number (RON) to perfect combustion and reduce carbon monoxide pollution from exhaust gases. The difference in electronegativity polarity causes the two fuels to be incompatible. This study aims to produce a homogeneous and compatible mixture of gasoline (85%) and bioethanol (15%) after the addition of crude palm oil (CPO) gum using degumming and distillation methods. The RON index calculation and physical properties of gasohol E-85 showed that the existence of CPO gum in bioethanol reduced the boiling point from 78 °C to 69 °C and the RON from 120 to 109. FTIR results showed that gasohol E-85 contains phosphatides, hydrocarbons, carboxylic acids, and tocopherols characteristic of CPO gum. The DSC results obtained a melting point of 43.8 °C which indicated that the CPO gum had mixed with bioethanol in gasohol E-85. The GC results of gasohol-85 obtained seven peaks indicating the presence of butylated hydroxytoluene, 1,9-decadiene, 4,4,7,7-tetramethyl, n-hexadecanoic acid, hexadecanoic acid, 2-hydroxy-1-(hydroxyl methyl) ethyl ester, 1-(3-methyl-2-butenyl)-2-phenylcyclopropane, and 9,9-bis(1"-indazolyl) -thioxanthene.
SYNTHESIS, ANTIMICROBIAL, AND ANTITUBERCULAR ACTIVITIES OF NOVEL N-PYRAZOLYLBENZAMIDE DERIVATIVES
Authors: J. Prathyusha  , Deepti C. Asha
Published: December 2022

The current study investigated the antimicrobial and antitubercular activities of novel N-Pyrazolyl Benzamide derivatives. The study includes the synthesis, characterization, and ligand-based molecular docking of the designed molecules. Synthesis of N-Pyrazolyl Benzamide derivatives involves a two-step process in which 5-amino pyrazole (3) intermediate is produced by the condensation reaction of aryl hydrazine (1) and β-keto nitrile (2) in acidic conditions. The final N-Pyrazolyl Benzamide derivatives (5a-n) were synthesized by the reaction involving amide coupling between 5-amino pyrazole (3) and various substituted benzoyl halides (4a-n). The compounds (5a-n) were tested for antimicrobial activity against two gram-negative strains (E. coli and S. Typhi), two gram-positive strains (S. aureus and B. subtilis) and M. tuberculosis MTB H37Rv (ATCC 27294) strains were used for evaluating antitubercular activity. Molecular docking studies of designed derivatives were performed with the Schrodinger glide package against mycobacterial pantothenate synthetase (PDB ID: 4MQ6). All the tested compounds displayed moderate to good antimicrobial and antitubercular activity against the selected strains of bacteria. All the docked molecules were found occupying the active site and established a minimum of two hydrogen bond interactions in molecular docking studies
SYNTHESIS OF CERIA NANOPARTICLES: EFFECT OF ALCOHOL/WATER RATIO ON THE MORPHOLOGY AND CRYSTAL STRUCTURE
Authors: S. Rusdi  , M.S. A. Chafidz
Published: December 2022

In this study, ceria nanoparticles were synthesized via one of the simplest methods, which is the precipitation method. The effects of three different ethanol/DI water ratios (i.e. 1:1; 1:4; 0:1) and post-heat treatments (i.e. drying only and drying + calcination) on the crystal structure and morphology of the ceria nanoparticles have been investigated. The characterization of the ceria nanoparticles was conducted using X-Ray Diffractometer (XRD) for the crystal structure and Transmission Electron Microscopy (TEM) for the morphology. From XRD analysis results, the comparison of the highest XRD intensity peaks (at 2θ = 28.6°) of the ceria nanoparticles samples showed that all the ceria nanoparticles samples with drying + calcination treatment were higher than the ones with drying treatment only. Additionally, the XRD peaks were analyzed using a well-known Scherrer’s equation to determine the average crystallite size of the ceria nanoparticles. It was found that the ceria nanoparticles sample prepared using the ethanol/DI water ratio of 1:1 (i.e. Ceria-C1) had the biggest average crystallite size (i.e. 14 nm). Nevertheless, the TEM analysis showed that Ceria-C1 showed better morphology and dispersion compared to other Ceria samples and also clearly exhibited sphere-like nanoparticles. This finding can be associated with the dispersion stability analysis, which showed that the suspension of Ceria-C1 shows a little bit better dispersion compared to other Ceria samples.
New guidelines for choosing priority areas of economic diversification based on a system of situational centers
Authors: Afanasiev Mikhail
Published: December 2022

One of the important management functions of the situation center system is to ensure planning (strategic, medium term, and operational), which includes justification of goals, optimal allocation of resources to achieve the goals, taking into account economic complexity, evolutionary conditionality and innovation activity. There is no universal solution to promote economic development and structural change. It is necessary to take into account the peculiarities of the regions when developing and designing industrial and economic policies. An approach to assessing priority areas of diversification based on recommendations for the development of sectors is presented. The approach is focused on increasing the economic complexity of the regional economy, taking into account the evolutionary conditionality of its development, the impact of innovative activity of regions and the provision of sectors with resources. Its capabilities have been tested for 14 sectors of the economy of the Belgorod region on 2019 data. For each sector, estimates were obtained according to six criteria. Sectors whose characteristics have the property of Pareto optimality in the considered multiple choice problem are priority when choosing the direction of diversification of the regional economy. The implementation of the proposed approach using digital technologies in regional situation centers can ensure coordination of decisions taken by regions when choosing priority areas of diversification in order to increase economic security. The methodology used makes it possible to take into account and display in real time in the initial information considered by any region the decisions already taken by other regions, which is an urgent task for the system of situational centers.
Literature Review: The Effectiveness First Aid Pressure Immobilization Bandages Technique of Snake Bite
Authors: Nopita Dian , Kamaluddin Ridlwan
Published: December 2022

Backgrounds: Snake bites are a medical emergency that can cause permanent disability and even death (Wintoko and Prameswari 2020). The main principle recommended for the first treatment of a snakebite is to immobilize the area with a pressure bandage (pressure immobilization bandages) then immediately referred to the hospital for further treatment.Objective: To know the effectiveness of pressure immobilization bandages (PIB) first aid against snake bite.Methods: Article searches were conducted electronically using Google Scholar, PubMed, Science direct, National Library and Pro quest databases. Articles used from 2016 to 2021. The keywords in this article search were “pressure immobilization bandages” and “snake bite. So that 5 research articles were reviewed. Inclusion criteria included articles published in 2016-2021, articles in Indonesian and English, involving snake bite patients and being given the Pressure immobilization bandage technique intervention. Meanwhile, the exclusion criteria include articles that cannot be accessed, based on meta-analysis, and journals that discuss snake bites but are not in accordance with the topic to be reviewed.Results: Pressure immobilization bandages (PIB) can be used in first aid because they can inhibit the spread of snake venom and are 20 times faster in the healing process if done in first aid.Conclusion: Pressure immobilization bandages (PIB) are effective in first aid for snake bites.Keywords: Pressure immobilization bandages; snake bite
CR Image Optimization and Radiation Dose Limitation With Collimation Adjusting on Cervical Radiography
Authors: Prastanti Agustina Dwi , Abimanyu Bagus , Kurniawan Andrey Nino , Nurbaiti Salis
Published: December 2022

Background: Radiological examination in cervical services, Radiographers often opening the collimation wider of the size of the imaging plate for fear of being cut. This is done because it is supported by the image cropping facility on the CR. So there is a habit of opening the collimation width as wide as the imaging plate, which is often done with the assumption that it is better to widen the collimation than cut off the object. Obviously this will increase the radiation dose in patients with basic limitations. According to ICRP, patient safety must refer to the principle of radiation protection ALARA namely in the shortest possible time to get quality radiographs and patients receive the most minimum radiation exposure as possible.Methods: This research is a descriptive analytic research conducted with a cross sectional approach. The study was conducted by varying the radiation field area to be used for cervical examination. There are 10 variations of collimation area with 3 (three) exposures in each collimation. Then measured contrast, noise and radiation dose. Radiation dose is calculated by means of a babyline device.Results: The results showed that the collimation setting did not affect contrast radiography in CR because collimation was not the main factor that could affect contrast radiography on CR. The collimation setting on cervical radiography has an effect on the radiation dose, so it is necessary to adjust the collimation to get the minimum dose possible. The most optimal collimation area on cervical radiographic examination was obtained at a size of 12 x 24 cm with the smallest noise reception and dose compared to others and had higher contrast. Average contrast value achieved was 0.45 with a dose of 39.23 µGy.Conclusion: The collimation setting on cervical radiography has an effect on the radiation dose, so it is very necessary to adjust the collimation to get the minimum dose possible. The most optimal collimation area on cervical radiographic examination is obtained at a size of 12 x 24 cm with the smallest noise reception and dose compared to others and has a higher contrast.
Keragaman Jenis Pohon dan Peresapan Air di Lahan Terbiarkan Setelah Kebun Tradisional
Authors: Karyati Karyati , Purwanti Emi , Mulyadi Rachmad , Ramadhanti Dita Putri Dwi , Setyono Dicky , Widiati Kusno Yuli , Sribianti Irma , Karmini Karmini
Published: December 2022

Ecological aspects of abandoned lands can be determine from many aspects, including the family diversity and the ability to absorb water. This study aims to determine the important value index based on tree family and the ability to absorb water (infiltration rate and permeability) on abandoned land after traditional gardens. The vegetation survey of trees with a diameter at breast height (DBH) >5 cm was carried out on 10 sub-plots each measuring 20 m × 20 m. Infiltration rate and permeability measurements were carried out 3 times with 3 repetitions each. The highest family significance values (FIV) were Euphorbiaceae (104.07), Moraceae (84.75), and Sapindaceae (20.94). The infiltration rates were 12.8 cm/hour in secondary forest (gentle slope), 6.0 cm/hour in secondary forest (a rather steep slope), 1.6 cm/hour in open land (gentle slope), and 1.2 cm/hour in open land (a slightly steep slope). Permeability in secondary forest (gentle slope), secondary forest (a rather steep slope), open land (gentle slope), and open land (a rather steep) were 15.45 cm/hour, 11.15 cm/hour, 9.82 cm/hour, and 8.93 cm/hour, respectively. Information about the diversity and water absorption can be used as a basis for consideration in managing abandoned lands in the future.
A Review on Bilayer Tablet Technology for Multi Modal Drug Delivery
Authors: Jangid Vikash , Chatterjee Dr. Arindam , Agrawal Dr. Vikash , Kumar Gupta Manoj , Garg Pradeep
Published: December 2022

Bilayer tablets are cutting-edge drug delivery technologies that enable the delivery of two medicines with various release patterns combined in a single unit. Bilayer tablets can deliver two incompatible medications in a single formulation, prolong the effect of the drug(s), and increase patient compliance. Bilayer tablets feature an active substance in one layer that is released immediately and another layer that is released later, either as a second dosage or in a prolonged release manner. The drawbacks of single-layered tablets are being overcome by the advancement of useful technology in bilayer tablets. Bilayer tablet technology requires a lot of resources, though. For each technical stage, a careful selection of excipients and manufacturing conditions is also necessary. High blood pressure patients frequently struggle or fail to control their BP with a single medication. To achieve treatment objectives, the majority of hypertension patients will require the use of two or more antihypertensive medications. When treating hypertension in patients whose blood pressure cannot be well controlled with monotherapy, combinations of antihypertensive medications from different categories have been demonstrated to be more successful than either medication alone. Combining two antihypertensive drugs with complementary modes of action may decrease blood pressure more effectively than using any one of these drugs by alone.

Keywords: Bi-layer tablet, Tablet manufacturing, Bi-layer tableting techniques.
The Definition of Covert Intelligence and the Examination of Its Efficiency
Authors: Csizner Zoltán
Published: December 2022

The exploration of the dreaded secrets of others, the collection of secret information and intelligence have been present in human communities since ancient times. Acquiring knowledge protected from unauthorised access has, over time, become a monopoly of a society organised into a state, and its implementation has been constrained by strict legislation. However, in addition to legitimacy, an equally important feature of covert intelligence is efficiency, which shows the relationship between the resources expended and the results achieved.How can their components be defined in an abstract way, can general criteria be named, and how can the results be measured and compared?The study seeks to answer these questions, which is a key part of research examining the relationship between the effectiveness and legitimacy of covert intelligence.It is also essential to present a complex and intricate system that helps to understand the regulation of covert intelligence and the organisations responsible for its implementation.
Windt Szandra: A láthatatlan emberek – Az emberkereskedelem jelensége Magyarországon
Authors: Tamási Erzsébet
Published: December 2022

Windt Szandra: A láthatatlan emberek. Az emberkereskedelem jelensége Magyarországon. OKRI, 2021, 236 o.
Raszternyomozás a kábítószer-bűncselekmények felderítésében
Authors: Jámbor Gellért
Published: December 2022

A raszternyomozás a számítógépes bűnügyi nyilvántartási rendszerekre épülő speciális adatelemző, tetteskutató módszer. A modern infrastruktúrát használó szervezett bűnözéssel szemben – mint amilyen az illegális kábítószerpiac is – a magyar rendőrségnek is folyamatosan fejlesztenie kell a kriminalisztikai logisztikát, a számítógépes rendszerektől egészen a titkosszolgálati eszköztárig.
ДЕПЕРСОНАЛІЗАЦІЙНО-ДЕРЕАЛІЗАЦІЙНИЙ РОЗЛАД З ГОСТРИМ І ПРОГРЕДІЄНТИМ ПОЧАТКОМ: ПОРІВНЯННЯ КЛІНІЧНИХ ВИПАДКІВ
Authors: КОБЗАР Оксана , ПИЛЯГІНА Галина
Published: December 2022

Анотація. Вступ. Поширеність деперсоналізаційно-дереалізаційного розладу (ДДР) серед психіатричних пацієнтів обумовлює актуальність теми дослідження. Аналіз останніх досліджень і публікацій. Патофізіологічний механізм деперсоналізації досі залишається нез’ясованим. Пусковими механізмом розвитку деперсоналізаційно-дереалізаційного розладу можуть бути: психотравмуючі події, дія психоактивних речовин, дія медикаментозних препаратів, розвиток іншого психічного захворювання тощо. В деяких випадках хвороба починається гостро, в інших – симптоми прогредієнтно наростають. Ппацієнти з ДДР схильні до надцінної саморефлексії з компульсивним скануванням своїх відчуттів. В якості психологічних захисних механізмів їм притаманні такі стрес-копінгові стратегії як соціальна ізоляція, самозвинувачення і румінації . Постановка проблеми. Феномен деперсоналізації – це «негативний» симптом», тому для пацієнта він складно піддається вербалізації та поясненню, що ускладнює його своєчасного виявлення у пацієнтів та проведенню якісної диференційної діагностики. Формулювання мети дослідження. Мета – ретельне вивчення випадків ДДР у окремих пацієнтів задля удосконалення діагностики та терапевтичних підходів при цих порушеннях. Матеріали та методи дослідження. В дослідженні були використані аналітичний, клінічний, клініко-психопатологічний, патопсихологічний, психодіагностичний, порівняльний методи. Для психометричної оцінки стану пацієнтів використовувався блок психометричних шкал: шкала Гамільтона для оцінки тривоги (HAM-A), шкала безнадійності Бека (BHI), шкала самооцінки тривоги Шихана (SPRAS), Кембріджський Деперсоналізаційний опитувальник (CDS), Шкала Дисоціації (DES), тест сенсо-життєвих орієнтацій в адаптації Леонтьєва (СЖО), тест Велика П’ятірка (Big Five Inventory). Результати дослідження. Незважаючи на відмінності в етіологічних факторах, патогенетичний механізм розвитку ДДР був спільний в обох клінічних випадках. Застосування комбінації есциталопрама та ламотриджину дало значне покращення для обох пацієнтів, але без повної редукції симптоматики. Висновки та перспективи подальших досліджень. Виявлено відмінності в етіологічних факторах розвитку ДДР, але схожість патогенетичного механізму розвитку, що має враховуватися при визначенні стратегії комплексного лікування пацієнтів із застосуванням психофармакотерапії та психотерапевтичного втручання для підвищення його ефективності. Відсутність однозначного погляду на нейробіологічні та нейрохімічні процеси, що лежать в основі ДДР, потребує подальшого вивчення патогенетичних механізмів цих розладів.
STRATEGI PENGEMBANGAN KAWASAN KESULTANAN BANTEN LAMA SEBAGAI WISATA HALAL DI PROVINSI BANTEN
Authors: Sajida Zia Permata , Syafrida Ida
Published: December 2022

Salah satu wisata yang dikemas dengan konsep halal di Provinsi Banten adalah Kawasan Kesultanan Banten Lama. Potensi wisatanya begitu besar, namun kurangnya tata kelola yang baik membuat potensinya menurun. Oleh karena itu tujuan dalam penelitian ini adalah untuk merumuskan strategi pengembangan Kawasan Kesultanan Banten Lama sebagai wisata halal di Provinsi Banten dengan mengidentifikasi manfaat, biaya, dan risiko yang muncul serta faktor strategis internal dan eksternal yang terdiri dari kekuatan, kelemahan, peluang, dan ancaman. Metode yang digunakan pada penelitian ini adalah dengan menggunakan metode matrik IFAS dan EFAS serta analisis SWOT. Dari hasil analisis IFAS dan EFAS diperoleh gambaran bahwa pengembangan wisata halal Kawasan Kesultanan Banten Lama harus terus ditingkatkan. Oleh karena itu strategi yang paling tepat digunakan adalah dengan menggunakan strategi progresif yakni dengan memanfaatkan seluruh kekuatan dan memanfaatkan peluang sebsar-besarnya. Hal tersebut dapat dilakukan dengan meningkatkan publikasi daya tarik objek di media sosial, menjadikan sektor pelaku usaha sebagai ekonomi kreatif, serta meningkatkan nilai tambah sejarah Kerajaan Islam dan nilai religi pada kesan wisatawan yang berkunjung ke Kawasan Kesultanan Banten Lama. Ketiga hal tersebut dilakukan untuk memaksimalkan pengembangan Kawasan Kesultanan Banten lama sebagai wisata halal di Provinsi Banten.

Kata kunci: wisata halal, matriks IFAS dan EFAS, analisis SWOT
Complicações do extravasamento de hipoclorito de sódio na Endodontia: artigo de revisão
Authors: Lazari Isabella Botelho
Published: December 2022

O hipoclorito de sódio (NaOCl) é útil para a desinfecção dos canais radiculares durante o preparo químico-mecânico do tratamento endodôntico e é uma substância muito tóxica e irritante aos tecidos, por isso, quando utilizada de forma incorreta pode extravasar para tecidos periapicais e desencadear reações alérgicas e acidentes, gerando complicações durante o procedimento endodôntico. Aos pacientes provoca alguns sinais e sintomas graves como, dor severa, edema, hemorragias, áreas de necroses e até infecções secundárias. Este trabalho foi desenvolvido para responder a seguinte questão norteadora: É possível trabalhar com hipoclorito de sódio em Endodontia mesmo com o risco de ocorrer complicações após o extravasamento? O objetivo foi realizar estudos e apresentar as consequências das complicações que possam vir a ocorrer com o uso inadequado do hipoclorito de sódio e apresentar medidas preventivas para evitar essa intercorrência. Foram realizadas pesquisas e incluídos artigo com ano de 2001 a 2021, através dos sites da pubmed, scielo e google acadêmico, foi utilizado palavras-chaves como “extravasamento de hipoclorito de sódio´´, “complicações com o uso de hipoclorito de sódio em Endodontia“. O resultado dos estudos informa que a irrigação pode ocorrer de forma segura e eficaz caso a substância seja utilizada de forma correta como, utilizar isolamento absoluto, evitar uso de força excessiva no momento da irrigação, uso de seringas de até 5 ml e agulha com saída lateral. Conclui-se que o extravasamento não é tão comum, mas há possibilidade de a extrusão ocorrer, e assim, é importante que o profissional esteja ciente sobre medidas preventivas e seu tratamento. O tratamento inclui alívio imediato da dor, amenizar o edema e prevenir infecções secundárias.
Evaluation of the invasion potential of monk parakeet, Myiopsitta monachus, in Natural Protected Areas in Mexico
Authors: Huerta–Sánchez S. A. , Huerta–Martínez F. M. , Muñoz–Urias A. , Neri–Luna C. , Sahagún–Sánchez F. J. , Castruita–Domínguez J. P.
Published: December 2022

The monk parakeet, Myiopsitta monachus, is a species of parrot that is native to South America. By 2016 it had become invasive in Mexico and its populations have since increased dramatically, particularly in urban areas. It is currently difficult to predict whether it will expand into non–urban areas of the country. The aim of this work was to assess the risk of invasion of this parakeet into the Natural Protected Areas (NPAs) of Mexico, where interaction with the native parrots is worrisome due to the aggressive nature of this parakeet. Using potential distribution models we evaluated this risk using MaxEnt. We performed a functional analysis of all native parrots of Mexico and M. monachus seeking possible competition or displacement of the species. According to the MaxEnt model, the Biosphere Reserve Tehuacán–Cuicatlán is the NPA with the highest risk of such invasion (~42 % of its area presents climatically suitable values ≥ 0.75). The functional trait assessment revealed that the barred parakeet, Bolborhynchus lineola, is the species most similar (97 %) to the invasive monk parakeet. It is naturally distributed in the Biosphere Reserve of Tehuacán–Cuicatlán and, from all functional traits considered, differs only in nesting type. This study shows the potential risk that the invasive monk parakeet represents in Mexican NPAs, and emphasizes the need for effective actions in order to avoid further potential invasions and expansions of the species occur across Mexico.
Speaker Recognition Based on Mutated Monarch Butterfly Optimization Configured Artificial Neural Network
Authors: Lakshmi Namburi Dhana , Sai Ram M Satya
Published: December 2022

Speaker recognition is the process of extracting speaker-specific details from voice waves to validate the features asserted by system users; in other words, it allows voice-controlled access to a range of services. The research initiates with extraction features from voice signals and employing those features in Artificial Neural Network (ANN) for speaker recognition. Increasing the number of hidden layers and their associated neurons reduces the training error and increases the computational process's complexity. It is essential to have an optimal number of hidden layers and their corresponding, but attaining those optimal configurations through a manual or trial and the process takes time and makes the process more complex. This urges incorporating optimization approaches for finding optimal hidden layers and their corresponding neurons. The technique involve in configuring the ANN is Mutated Monarch Butterfly Optimization (MMBO). The proposed MMBO employed for configuring the ANN achieves the sensitivity of 97.5% in a real- time database that is superior to contest techniques.