Supplementary Methods, Figures S1 - S3 from Genome-Wide Meta-Analyses of Breast, Ovarian, and Prostate Cancer Association Studies Identify Multiple New Susceptibility Loci Shared by at Least Two Cancer Types
Authors: Kar Siddhartha P. , Beesley Jonathan , Amin Al Olama Ali , Michailidou Kyriaki , Tyrer Jonathan , Kote-Jarai ZSofia , Lawrenson Kate , Lindstrom Sara , Ramus Susan J. , Thompson Deborah J. , Kibel Adam S. , Dansonka-Mieszkowska Agnieszka , Michael Agnieszka , Dieffenbach Aida K. , Gentry-Maharaj Aleksandra , Whittemore Alice S. , Wolk Alicja , Monteiro Alvaro , Peixoto Ana , Kierzek Andrzej , Cox Angela , Rudolph Anja , Gonzalez-Neira Anna , Wu Anna H. , Lindblom Annika , Swerdlow Anthony , Ziogas Argyrios , Ekici Arif B. , Burwinkel Barbara , Karlan Beth Y. , Nordestgaard Børge G. , Blomqvist Carl , Phelan Catherine , McLean Catriona , Pearce Celeste Leigh , Vachon Celine , Cybulski Cezary , Slavov Chavdar , Stegmaier Christa , Maier Christiane , Ambrosone Christine B. , Høgdall Claus K. , Teerlink Craig C. , Kang Daehee , Tessier Daniel C. , Schaid Daniel J. , Stram Daniel O. , Cramer Daniel W. , Neal David E. , Eccles Diana , Flesch-Janys Dieter , Edwards Digna R. Velez , Wokozorczyk Dominika , Levine Douglas A. , Yannoukakos Drakoulis , Sawyer Elinor J. , Bandera Elisa V. , Poole Elizabeth M. , Goode Ellen L. , Khusnutdinova Elza , Høgdall Estrid , Song Fengju , Bruinsma Fiona , Heitz Florian , Modugno Francesmary , Hamdy Freddie C. , Wiklund Fredrik , Giles Graham G. , Olsson Håkan , Wildiers Hans , Ulmer Hans-Ulrich , Pandha Hardev , Risch Harvey A. , Darabi Hatef , Salvesen Helga B. , Nevanlinna Heli , Gronberg Henrik , Brenner Hermann , Brauch Hiltrud , Anton-Culver Hoda , Song Honglin , Lim Hui-Yi , McNeish Iain , Campbell Ian , Vergote Ignace , Gronwald Jacek , Lubiński Jan , Stanford Janet L. , Benítez Javier , Doherty Jennifer A. , Permuth Jennifer B. , Chang-Claude Jenny , Donovan Jenny L. , Dennis Joe , Schildkraut Joellen M. , Schleutker Johanna , Hopper John L. , Kupryjanczyk Jolanta , Park Jong Y. , Figueroa Jonine , Clements Judith A. , Knight Julia A. , Peto Julian , Cunningham Julie M. , Pow-Sang Julio , Batra Jyotsna , Czene Kamila , Lu Karen H. , Herkommer Kathleen , Khaw Kay-Tee , Matsuo Keitaro , Muir Kenneth , Offitt Kenneth , Chen Kexin , Moysich Kirsten B. , Aittomäki Kristiina , Odunsi Kunle , Kiemeney Lambertus A. , Massuger Leon F.A.G. , Fitzgerald Liesel M. , Cook Linda S. , Cannon-Albright Lisa , Hooning Maartje J. , Pike Malcolm C. , Bolla Manjeet K. , Luedeke Manuel , Teixeira Manuel R. , Goodman Marc T. , Schmidt Marjanka K. , Riggan Marjorie , Aly Markus , Rossing Mary Anne , Beckmann Matthias W. , Moisse Matthieu , Sanderson Maureen , Southey Melissa C. , Jones Michael , Lush Michael , Hildebrandt Michelle A.T. , Hou Ming-Feng , Schoemaker Minouk J. , Garcia-Closas Montserrat , Bogdanova Natalia , Rahman Nazneen , Le Nhu D. , Orr Nick , Wentzensen Nicolas , Pashayan Nora , Peterlongo Paolo , Guénel Pascal , Brennan Paul , Paulo Paula , Webb Penelope M. , Broberg Per , Fasching Peter A. , Devilee Peter , Wang Qin , Cai Qiuyin , Li Qiyuan , Kaneva Radka , Butzow Ralf , Kopperud Reidun Kristin , Schmutzler Rita K. , Stephenson Robert A. , MacInnis Robert J. , Hoover Robert N. , Winqvist Robert , Ness Roberta , Milne Roger L. , Travis Ruth C. , Benlloch Sara , Olson Sara H. , McDonnell Shannon K. , Tworoger Shelley S. , Maia Sofia , Berndt Sonja , Lee Soo Chin , Teo Soo-Hwang , Thibodeau Stephen N. , Bojesen Stig E. , Gapstur Susan M. , Kjær Susanne Krüger , Pejovic Tanja , Tammela Teuvo L.J. , Dörk Thilo , Brüning Thomas , Wahlfors Tiina , Key Tim J. , Edwards Todd L. , Menon Usha , Hamann Ute , Mitev Vanio , Kosma Veli-Matti , Setiawan Veronica Wendy , Kristensen Vessela , Arndt Volker , Vogel Walther , Zheng Wei , Sieh Weiva , Blot William J. , Kluzniak Wojciech , Shu Xiao-Ou , Gao Yu-Tang , Schumacher Fredrick , Freedman Matthew L. , Berchuck Andrew , Dunning Alison M. , Simard Jacques , Haiman Christopher A. , Spurdle Amanda , Sellers Thomas A. , Hunter David J. , Henderson Brian E. , Kraft Peter , Chanock Stephen J. , Couch Fergus J. , Hall Per , Gayther Simon A. , Easton Douglas F. , Chenevix-Trench Georgia , Eeles Rosalind , Pharoah Paul D.P. , Lambrechts Diether 
Published: April 2023

<p>Supplementary Figure S1. LocusZoom regional association plots for the seven new cross-cancer loci that were > 1 Mb from known index SNPs. Supplementary Figure S2A-B. Box plots showing eQTL associations between (A) rs9375701 and L3MBTL3 in normal breast and prostate tissues and (B) rs8037137 and RCCD1 in normal breast and ovarian tissues. Supplementary Figure S3. Interactions between BCL2L11 and the 32 Biocarta "Death Pathway" genes. Interactions were identified using the GeneMania server. Circles contain gene names, lines represent interactions, and the color of the line indicates a specific type of interaction as listed in the legend.</p>