bluuebunny/crossref_metadata_2025 huggingface dataset:
A Novel Noise Reduction Method of UAV Magnetic Survey Data Based on CEEMDAN, Permutation Entropy, Correlation Coefficient and Wavelet Threshold Denoising
Authors: Zheng Yaoxin , Li Shiyan , Xing Kang , Zhang Xiaojuan
Published: October 2021

Despite the increased attention that has been given to the unmanned aerial vehicle (UAV)-based magnetic survey systems in the past decade, the processing of UAV magnetic data is still a tough task. In this paper, we propose a novel noise reduction method of UAV magnetic data based on complete ensemble empirical mode decomposition with adaptive noise (CEEMDAN), permutation entropy (PE), correlation coefficient and wavelet threshold denoising. The original signal is first decomposed into several intrinsic mode functions (IMFs) by CEEMDAN, and the PE of each IMF is calculated. Second, IMFs are divided into four categories according to the quartiles of PE, namely, noise IMFs, noise-dominant IMFs, signal-dominant IMFs, and signal IMFs. Then the noise IMFs are removed, and correlation coefficients are used to identify the real signal-dominant IMFs. Finally, the wavelet threshold denoising is applied to the real signal-dominant IMFs, the denoised signal can be obtained by combining the signal IMFs and the denoised IMFs. Both synthetic and field experiments are conducted to verify the effectiveness of the proposed method. The results show that the proposed method can eliminate the interference to a great extent, which lays a foundation for the further interpretation of UAV magnetic data.
Reconfigurable Morphological Processor for Grayscale Image Processing
Authors: Zhang Bin
Published: October 2021

Grayscale morphology is a powerful tool in image, video, and visual applications. A reconfigurable processor is proposed for grayscale image morphological processing. The architecture of the processor is a combination of a reconfigurable grayscale processing module (RGPM) and peripheral circuits. The RGPM, which consists of four grayscale computing units, conducts grayscale morphological operations and implements related algorithms of more than 100 f/s for a 1024 × 1024 image. The periphery circuits control the entire image processing and dynamic reconfiguration process. Synthesis results show that the proposed processor can provide 43.12 GOPS and achieve 8.87 GOPS/mm2 at a 220-MHz system clock. The simulation and experimental results show that the processor is suitable for high-performance embedded systems.
Effect of Divided Exhaust Period in a High Efficiency TGDI Engine
Authors: Oh Heechang , Jung Dongwon , Son Jinwook , Woo Soohyung , Roth David , Song Jerry , Kweon Youngmyung , Hwang Joonsik
Published: October 2021

The divided exhaust period (DEP) concept was applied to a high-efficiency gasoline engine and its impact on various engine performance aspects were investigated. To this end, key design parameters of DEP components were optimized through 1-D engine simulation. The designed DEP components were fabricated and experimental verification was performed through an engine dynamometer test. The developed DEP engine shows suitable performance for electrified vehicles, with a maximum thermal efficiency of 42.5% as well as a wide sweet spot area of efficiency over 40%. The improvement in thermal efficiency was mainly due to a reduction in pumping loss. Notably, the reduction in pumping loss was achieved under high exhaust gas recirculation (EGR) flow conditions, where further improvements in fuel consumption could be achieved through a synergistic combination of DEP implementation and high dilution combustion. Furthermore, a significantly improved catalyst light-off time, uncharacteristic in turbocharged engines, was confirmed through a simulated cold-start catalyst heating engine test.
Use Performance and Management of Biodegradable Fluids as Transformer Insulation
Authors: García Belén , Ortiz Alfredo , Renedo Carlos , García Diego Fernando , Montero Andrés
Published: October 2021

In recent years, the use of biodegradable fluids as liquid insulation for distribution and power transformers is spreading. The main biodegradable fluids used are natural and synthetic esters, although biodegradable hydrocarbons have been recently proposed. Biodegradable fluids have a much lower environmental impact than mineral oil, limiting the risk of soil contamination in leaks, which makes them a suitable solution for applications such as offshore transformers or railway transformers. Additionally, these fluids have a higher flash point than conventional mineral oils, which dramatically reduces the risk of fire and collateral damage derived from explosion and fire. Despite these advantageous factors, there are still some aspects that hinder the broadening of their use, such as the difference in thermal properties or the lack of accepted maintenance procedures for transformers that use them as liquid insulation. This paper presents the current status of biodegradable insulating fluids, analyzing some of their properties and discussing the aspects that are still to be investigated in order to make them a real alternative to petroleum-based fluids.
Costs to Reduce the Human Health Toxicity of Biogas Engine Emissions
Authors: Benato Alberto , Macor Alarico
Published: October 2021

The anaerobic digestion of biodegradable substrates and waste is a well-known process that can be used worldwide to produce a renewable fuel called biogas. At the time of writing, the most widespread way of using biogas is its direct usage in combined heat and power internal combustion engines (CHP-ICEs) to generate electricity and heat. However, the combustion process generates emissions, which in turn have an impact on human health. Therefore, there is a need to: (i) measure the ICE emissions (both regulated and unregulated), (ii) compute the impact on human health, (iii) identify the substances with the highest impact and (iv) calculate the avoided damage to human health per Euro of investment in technology able to abate the specific type of pollutant. To this end, the authors conducted an experimental campaign and selected as a test case a 999 kWel biogas internal combustion engine. Then, the collected data, which included both regulated and unregulated emissions, were used to calculate the harmfulness to human health and identify the more impactful compounds. Thus, combining the results of the impact analysis on human health and the outcomes of a market analysis, the avoided damage to human health per Euro of investment in an abatement technology was computed. In this manner, a single parameter, expressed in DALY €−1, provided clear information on the costs to reduce each disability-adjusted life year (DALY). The impact analysis on human health, which was performed using the Health Impact Assessment, showed that NOx was the main contributor to damage to human health (approximately 91% of the total), followed by SOx (6.5%), volatile organic compounds (1.4%) and CO (0.7%). Starting from these outcomes, the performed investigation showed that the technology that guarantees the maximum damage reduction per unit of cost is the denitrification system or the oxidizing converter, depending on whether the considered plant is already in-operation or newly built. This is an unexpected conclusion considering that the most impacting emission is the NOx.
Efficient Link Scheduling Based on Estimated Number of Packets in Queue on Industrial Wireless Sensor Networks
Authors: Kim Myung-Kyun
Published: October 2021

The links of low power wireless sensor networks are error prone and the transmission on a wireless link is determined probabilistically by the packet reception rate (PRR) of the link. On the other hand, there is a very strict requirement in the end-to-end reliability and delay of sensor data in industrial wireless sensor networks (IWSNs). The existing approaches to provide the end-to-end reliability in IWSNs is retransmitting the packet when failure occurs. These approaches transmit a packet multiple times in successive time slots to provide the required reliability. These approaches, however, can increase the average delay of packets and the number of packets buffered in a queue. This paper proposes a new scheme to estimate the probabilistic amount of packets, called queue level (QL), in the buffer of each node based on the PRRs of the wireless links. This paper also proposes a QL-based centralized scheduling algorithm to assign time slots efficiently in TDMA-based IWSNs. The proposed scheduling algorithm gives higher priority to the nodes with higher QL. By assigning time slots first to the node with the highest QL, we can reduce the average end-to-end delay of packets and reduce the amount of buffered packets in the queue while satisfying the required end-to-end reliability. The performance of the proposed scheduling algorithm have been evaluated through a simulation using the Cooja simulator and compared with the existing approach. In the simulation on an sample network with the target end-to-end reliability of 99%, all of the flows were shown to guarantee the target reliability in both algorithms: on average, 99.76% in the proposed algorithm and 99.85% in the existing approach. On the other hand, the proposed algorithm showed much better performance than the existing approach in terms of the average end-to-end delay of packets (about 47% less) and the number of maximally buffered packets in the queue of each node (maximally, more than 90% less).
Optimization of a novel Hybrid Wind Bio Battery Solar Photovoltaic System Integrated with Phase Change Material
Authors: Mudgal Vijay , Singh Preeti , Khanna Sourav , Pandey Chandan , Becerra Victor , Mallick Tapas K. , Reddy K. S.
Published: October 2021

The intermittent nature of renewable sources, such as solar and wind, leads to the need for a hybrid renewable energy system (HRES) that can provide uninterrupted and reliable energy to a remote and off-grid location with the use of a biogas generator and battery. In the present study, conventional PV panels have been integrated with phase change material (PCM) for power enhancement. In addition, various configurations (i. PV-Wind-Battery system, ii. PV-PCM-Wind-Battery, iii. PV-Wind-Biogas-Battery and iv. PV-PCM-Wind-Biogas-Battery) have been compared for the hot and humid climatic location of Chennai, India. Optimization has been carried out to minimize the cost of energy and the net present cost has also been computed. It has been found that the integration of PCM with the PV-Wind-Biogas-Battery-based off-grid system results in savings of USD 0.22 million in terms of net present cost and reduces the cost of energy from USD 0.099/kWh to USD 0.094/kWh. Similarly, for another off-grid HRES configuration of PV-Wind-Battery, the integration of PCM results in savings of USD 0.17 million, and reduces the cost of energy from USD 0.12/kWh to USD 0.105/kWh.
Reduction of the Environmental Impact of Electric Field Generated by High Voltage Power Transmission Lines
Authors: Tarko Rafał , Kochanowicz Konrad , Nowak Wiesław , Szpyra Waldemar , Wszołek Tadeusz
Published: October 2021

The growing interest in the negative environmental impact of overhead power lines of high and extra-high voltage stems from the increasing ecological awareness of societies. Consequently, a number of respective legal restrictions have been issued and actions have been undertaken to reduce this impact, especially in the electric field of the power frequency. The aim of this paper is to analyze the possibilities of reducing the width of electric field influence zones by changing the design parameters of power lines and defining the spatial distribution of its conductors. This analysis was carried out using the developed and experimentally verified models for determining the electric field and audible noise in the power line environment. The computational models were used to analyze the width of the electric field influence zones of 400 kV lines and the noise levels at the borders of these zones. The research focused on single and double circuit 400 kV power lines. It was revealed that a reduction in electric field emissions is accompanied by an increase in noise emission. However, the analyses confirmed that the width of the electric field influence zones can be significantly reduced if the most important design and construction parameters of the line are properly selected. The obtained conclusions are valid not only for 400 kV lines, but also set directions to follow when changing the parameters of high voltage transmission lines of other rated voltages (above 100 kV).
Oxidation Experiments and Kinetics Analysis of Nuclear Graphite ET-10 by Gas Analysis and Microstructure Observation
Authors: Zhao Yumeng , Dong Yujie , Zhou Yangping , Li Zhengcao , Zhang Zuoyi
Published: October 2021

Nuclear graphite can be used in fission and fusion systems due to its excellent nuclear performance and mechanical properties where the ability of oxidation resistance is usually concerned. Although the excellent performance of new graphite ET-10 was revealed by previous experiments regarding the accident conditions of a fission reactor, further studies are needed to oxidize the graphite under the conditions recommended by the ASTM D7542 standard. A test facility was designed and developed to oxidize the cylindrical specimen with a 10 L/min airflow. According to oxidation rates and microstructures of specimens, the chemical kinetics-controlled regime was determined as 675–750 °C, where the activation energy was obtained as 172.52 kJ/mol. The experiment results revealed the excellent ability of graphite ET-10 for oxidation resistance with lower oxidation rates and longer oxidation times compared with some mainstream graphite. The main reasons are the low contents of some impurities and the binder and the low active surface area due to the non-impregnation baking process undertaken to produce graphite with coal tar pitch coke. It should be noted that the evolution of oxidation behavior at the bottom part of the specimen (facing the airflow) was quicker than that at the upper part of the specimen. We also suggest that the abundance of oxygen supply and the good linearity of the Arrhenius plot are prerequisites of the chemical kinetics-controlled regime rather than sufficient conditions.
Stable Semi-Transparent Dye-Sensitized Solar Modules and Panels for Greenhouse Application
Authors: Barichello Jessica , Vesce Luigi , Mariani Paolo , Leonardi Enrico , Braglia Roberto , Di Carlo Aldo , Canini Antonella , Reale Andrea
Published: October 2021

Our world is facing an environmental crisis that is driving scientists to research green and smart solutions in terms of the use of renewable energy sources and low polluting technologies. In this framework, photovoltaic (PV) technology is one of the most worthy of interest. Dye-sensitized solar cells (DSSCs) are innovative PV devices known for their encouraging features of low cost and easy fabrication, good response to diffuse light and colour tunability. All these features make DSSCs technology suitable for being applied to the so-called agrovoltaic field, taking into account their dual role of filtering light and supporting energy needs. In this project, we used 40 DSSC Z-series connected modules with the aim of combining the devices’ high conversion efficiency, transparency and robustness in order to test them in a greenhouse. A maximum conversion efficiency of 3.9% on a 221 cm2 active area was achieved with a transparency in the module’s aperture (312.9 cm2) area of 35%. Moreover, different modules were stressed at two different temperature conditions, 60 °C and 85 °C, and under light soaking at the maximum power point, showing a strong and robust stability for 1000 h. We assembled the fabricated modules to form ten panels to filter the light from the roof of the greenhouse. We carried out panel measurements in outdoor and greenhouse environments in both sunny and cloudy conditions to find clear trends in efficiency behaviour. A maximum panel efficiency in outdoor conditions of 3.83% was obtained in clear and sunny sky conditions.
Comparative Analysis of Strength and Modal Characteristics of a Full Tubular Pump and an Axial Flow Pump Impellers Based on Fluid-Structure Interaction
Authors: Shi Lijian , Zhu Jun , Wang Li , Chu Shiji , Tang Fangping , Jin Yan
Published: October 2021

Fluid-structure interaction (FSI) was used to determine the structural mechanical characteristics of full tubular and axial-flow pumps. The results showed that as the flow rate increases, the total deformation and equivalent stress are significantly reduced. The max total deformation (MTD) and the max equivalent stress (MES) of the full tubular pump impeller occur on the outer edge of the blade. There are two stress concentrations in the full tubular pump impeller, one of which is located in the outlet area of the rim, and the other is located in the outlet area of the hub. However, the MES of the axial-flow pump appears in the center of the blade hub. The performance difference between the full tubular pump and the axial-flow pump is mainly caused by the clearance backflow. The natural frequency of the full tubular pump is lower than that of the axial-flow pump on the basis of the modal results. The MES of the full tubular pump is mainly concentrated at the junction of the blade and the motor rotor, and the max thickness of the rim is 6mm, which can be more prone to cracks and seriously affect the safety and stability of the pump.
Systemic Risk Spillovers in the European Energy Sector
Authors: Lupu Radu , Călin Adrian Cantemir , Zeldea Cristina Georgiana , Lupu Iulia
Published: October 2021

In this article, we aim to study systemic risk spillovers for European energy companies and to determine the spillover network of the energy sector with other economic sectors. To examine the spillovers within the energy sector, we employ three systemic risk measures. We then embed the results of these models into a Diebold–Yilmaz framework. Moreover, we consider an entropy procedure to extract a Bayesian formulation of its systemic risk spillover. This allows us to determine which company in our sample contributes the most to systemic risk, which company is the most vulnerable to systemic risk, and the place of the energy sector within risk networks. Our results reveal the fact that all companies manifest enhanced spillovers during 2008, early 2009, and 2020. These episodes are associated with the dynamics of the global financial crisis and the pandemic crisis. We notice that specific companies are risk drivers in the sector in both times of market turbulence and calm. Lastly, we observe that several economic sectors such as banks, capital goods, consumer services, and diversified financials generate relevant spillovers towards the energy sector.
Genetic Diversity and Population Structure of the Asian Tiger Mosquito (Aedes albopictus) in Vietnam: Evidence for Genetic Differentiation by Climate Region
Authors: Duong Cuong-Van , Kang Ji-Hyoun , Nguyen Vinh-Van , Bae Yeon-Jae
Published: October 2021

Aedes albopictus is a native mosquito to Southeast Asia with a high potential for disease transmission. Understanding how Ae. albopictus populations that develop in the species’ native range is useful for planning future control strategies and for identifying the sources of invasive ranges. The present study aims to investigate the genetic diversity and population structure of Ae. albopictus across various climatic regions of Vietnam. We analyzed mitochondrial cytochrome oxidase I (COI) gene sequences from specimens collected from 16 localities, and we used distance-based redundancy analysis to evaluate the amount of variation in the genetic distance that could be explained by both geographic distance and climatic factors. High levels of genetic polymorphism were detected, and the haplotypes were similar to those sequences from both temperate and tropical regions worldwide. Of note, these haplotype groups were geographically distributed, resulting in a distinct population structure in which northeastern populations and the remaining populations were genetically differentiated. Notably, genetic variation among the Ae. albopictus populations was driven primarily by climatic factors (64.55%) and to a lesser extent was also influenced by geographic distance (33.73%). These findings fill important gaps in the current understanding of the population genetics of Ae. albopictus in Vietnam, especially with respect to providing data to track the origin of the invaded regions worldwide.
The Dominance of Chitosan Hydrochloride over Modern Natural Agents or Basic Substances in Efficacy against Phytophthora infestans, and Its Safety for the Non-Target Model Species Eisenia fetida
Authors: Žabka Martin , Pavela Roman
Published: October 2021

Growing pressure to reduce the environmental pesticide burden has the greatest impact on agriculture and crop protection. There is an enormous increase in the demand for research on new, effective, naturally based agents that do not pose an environmental risk. Phytophthora infestans is one of the most destructive phytopathogens, especially in cases where synthetic fungicides are not allowed. This paper describes the high efficacy and safety of the natural polymer chitosan under in vitro and in vivo conditions and its dominance over other natural agents or products. Chitosan demonstrated the highest efficacy against P. infestans. A concentration of 0.2–0.4% was highly effective. The protective effect of chitosan was 99.3% in natural conditions. Direct activity, equivalent to synthetic fungicides (MIC50 0.293 mg/mL), was confirmed. Chitosan was rated non-toxic to useful non-target species. We promote further chitosan expansion within legislation and implementation of chitosan as a safe substance that could reduce the pesticide burden, particularly in eco-friendly plant protection and production of non-harmful foods.
An 8-Week Program of Plyometrics and Sprints with Changes of Direction Improved Anaerobic Fitness in Young Male Soccer Players
Authors: Aloui Ghaith , Hermassi Souhail , Khemiri Aymen , Bartels Thomas , Hayes Lawrence D. , Bouhafs El Ghali , Souhaiel Chelly Mohamed , Schwesig René
Published: October 2021

This study examined the effects of 8 weeks of twice-weekly combined plyometric and sprint with change-of-direction (CPSCoD) training into habitual training regimes of young male soccer players. Participants were randomly allocated to an experimental group (n = 17, age: 14.6 ± 0.44 years, body mass: 61.2 ± 7.34 kg, height: 1.67 ± 0.09 m, body fat: 11.2 ± 1.56%) and a control group (n = 16, age: 14.6 ± 0.39 years, body mass: 61.1 ± 3.96 kg, height: 1.67 ± 0.05 m, body fat: 11.8 ± 1.47%). Measures obtained pre- and post intervention included vertical and horizontal jump performance (i.e., squat jump (SJ), countermovement jump (CMJ), and standing long jump (SLJ)), and sprint performance (i.e., 5 m and 20 m sprint). In addition, Measures obtained pre- and post-intervention included change-of-direction ability (4 × 5 m sprint test (S 4 × 5 m) and sprint 9–3–6–3–9 m with backward and forward running (SBF)), repeated change of direction (RCoD), and static balance performance (stork balance test). The training group experienced superior jump (all p < 0.05; d ≥ 0.61), sprint (all p < 0.05; d ≥ 0.58), change-of-direction (CoD) ability (all p < 0.05; d ≥ 0.58), RCoD (all parameters except the fatigue index p < 0.01; effect size (d) ≥ 0.71), and static balance (all p < 0.05; d ≥ 0.66) improvement. Adding twice-weekly CPSCoD training to standard training improves the anaerobic performance of U15 male soccer players.
Regul-A: A Technological Application for Sensory Regulation of Children with Autism Spectrum Disorder in the Home Context
Authors: Reis Helena , Eusébio Inês , Sousa Margarida , Ferreira Mariana , Pereira Raquel , Dias Sara , Reis Catarina I.
Published: October 2021

(1) Background: Sensory processing disorder is now recognised as a core feature of autism spectrum disorder that influences children’s adaptive behaviours, which, in turn, may interfere with their participation in life situations. This study describes the process of developing a technological platform, in the form of an app, to help families regulate children with ASD, aged 3–6 years old, by applying sensory strategies to improve the child’s participation in daily routines in the home context. (2) Methods: A focus group formed by four specialised occupational therapists who intervene with children with ASD was selected in order to understand and discuss content that should be included in the app. At a later stage, a group of three was involved to ensure quality and veracity in technological platform elaboration. (3) Results: The purpose of the app, named Regul-A, is to help parents regulate children with ASD regarding their participation in home routines. The sensory strategies provided by the focus group in the three major occupations of the child were the first results obtained, followed by the development of the app structure. (4) Conclusions: The next phase of the study will be the use of the platform by families of children with ASD and occupational therapists. It is believed that, in the future, Regul-A will be used as a tool to gather, analyse and manage data on the occupational performance of children with ASD in the home context, particularly for activities of daily living, sleep, rest and play, facilitating the implementation of strategies and the sharing of information between parents and occupational therapists.
Experiences and Perceptions of Nursing Students during the COVID-19 Crisis in Spain
Authors: Rodríguez-Almagro Julián , Hernández-Martínez Antonio , Romero-Blanco Cristina , Martínez-Arce Alejandro , Prado-Laguna Maria del Carmen , García-Sanchez Francisco Jose
Published: October 2021

In the early stages of the 2019 coronavirus pandemic in Spain, the Spanish health system was overwhelmed, mainly due to a lack of personnel, and many hospital centers collapsed by following avalanche of patients with COVID-19; this meant that the National System of Health called for fourth-year nursing students to come to the hospital as health care personnel. Our aim was to describe the perceptions and experiences of a sample of nursing students during the early stages of the outbreak. We conducted a qualitative study with an empirical-phenomenological approach. Twenty nursing students in their final year of study in Spain were recruited using purposive and snowball sampling. They participated in in-depth interviews between 20 April and 10 May 2020. The interviews were transcribed and then analyzed using Haase’s adaptation of Colaizzi’s phenomenological method. Four main themes emerged from data analysis: “social responsibility and pride as a health worker”, “pressure caused by working with COVID-19 patients”, “feeling defenseless and let down”, and “personal growth as a health worker”. These main themes were further divided into 11 theme categories. Due to an intense work day for several days in a row, the students were tired and mentally exhausted. Even so, they managed to overcome any difficulties, demonstrating their professional dedication and resilience. Greater preparatory support should be provided to safeguard the well-being of these future healthcare providers. More intensive preparatory training is necessary for health sciences students to facilitate crisis preparedness and effective crisis management. It is necessary to implement support from healthcare systems, including sufficient personal protective equipment, as well as contracts that accurately reflect the work they do. It is necessary for nursing supervisors to have effective communication in the performance of their functions with nursing students; this dialogue helps to clearly explain which are the functions that students must perform when they are carrying out their internships. There is also a need for preparatory training in managing infectious diseases such as COVID-19.
Motivational Factors in the Use of Videoconferences to Carry out Tutorials in Spanish Universities in the Post-Pandemic Period
Authors: Infante-Moro Alfonso , Infante-Moro Juan C. , Gallardo-Pérez Julia , Luque-de la Rosa Antonio
Published: October 2021

Many of the tools used for virtual teaching during the pandemic had not been used previously, but they could continue to be used when traditional teaching returns. For this reason, this study focused on locating the key motivational factors for the possible continuation of the use of one of these tools, videoconferencing, to carry out tutorials in Spanish universities as a complement to face-to-face tutorials. For this, a literary review was conducted to obtain a list of motivational factors that may influence teachers to continuing using it, and a causal study was performed with university professors (through fuzzy cognitive maps) to identify the causal relationships among these factors and classify them by their relevance in making a decision. The most influential factors are intention, attitude and perceived compatibility with how tutorials are given, and the negative factors include quality management and trust.
Assistive Technology Provider Experiences during the COVID-19 Pandemic
Authors: Puli Louise , Layton Natasha , Mont Daniel , Shae Kylie , Calvo Irene , Hill Keith D. , Callaway Libby , Tebbutt Emma , Manlapaz Abner , Groenewegen Inge , Hiscock Diana
Published: October 2021

Globally, health systems face challenges in the delivery of assistive technology (AT) and only 10% of people are currently able to access the assistive products they need. The COVID-19 pandemic presented an uncharted path for AT providers to navigate, placing them under pressure to be agile and rapidly adapt. This article, part of a series, explores the experiences and impacts of the COVID-19 pandemic on AT providers and aims to inform how AT providers can be better prepared and supported in the future. A mixed methods approach was used to gather service data and perspectives from AT providers via a survey. A total of 37 responses were received from 18 countries. Service data showed extensive service disruption throughout 2020. Thematic analysis suggested significant changes to routine AT service delivery including rapid momentum towards home-based, decentralised, and digital services for which many AT providers were not prepared. Providers were required to make difficult decisions and deliver services in new ways to balance meeting demands, complying with government restrictions, and ensuring the safety of staff and clients. Few but important positives were expressed including the belief that expanded capacity to use remote and digital AT service delivery would remain useful in the future.
Impact of COVID-19 on Life of Students: Case Study in Hong Kong
Authors: Lee Albert , Keung Vera M. W. , Lau Vincent T. C. , Cheung Calvin K. M. , Lo Amelia S. C.
Published: October 2021

COVID-19 has an impact on the day-to-day life of students, with school closure and detrimental effects on health and well-being that cannot be underestimated. A study collected data reflecting the health and well-being of secondary school students entering a programme entitled “Healthy Life Planning: Assist Students to Acquire and Practice Health Knowledge and Skills” (ASAP study) in September and October 2019 before the outbreak of COVID-19. Follow-up data were collected in June and July 2020, over half a year since the spread of COVID-19, which facilitated analyses of its impact on the health behaviours and well-being of young people. Comparative analyses between baseline and the follow-up period were conducted on weight status, sleep pattern and quality, pattern of sedentary lifestyle, pattern of physical activity, attitudes and perceived barriers for exercise, and hand hygiene. Attitudes toward precautionary measures and influenza vaccination, self-reported changes in hygiene practices, exercise habits and eating habits were analysed. Although hygiene habits and risk perceptions among young people have improved in many aspects, the level of physical activity has declined as well as the beliefs and attitudes on increasing time on electronic media and change in sleep hygiene. Attitudes and beliefs towards influenza vaccination have declined, which would reflect the slow increase in the uptake rate of COVID-19 vaccination. Health education should equip students with the knowledge and skills to cultivate beliefs and attitudes to face health challenges.
Coping with Stress in Complicated Pregnancy and Gestational Weight Gain
Authors: Rolińska Agnieszka , Aftyka Anna , Samardakiewicz Marzena
Published: October 2021

Maternal obesity is one of the leading health problems in the world. Excessive gestational weight gain (GWG) can lead to many complications during pregnancy, especially when it is accompanied by diabetes. Moreover, the risk of excessive GWG in pregnant women is significant, irrespective of prenatal counseling. Studies on this subject concerning coping with stress are lacking in the literature. The present work is aimed at evaluating the styles of coping with stress and their relation to GWG in pregnant women with gestational diabetes (GDM) for whom sudden adaptation to dietary management during this period can be challenging. It was indicated that women with GDM reported high stress related to potential maternal-fetal complications and worries about compliance with dietary management. The overall weight gain of participants in pregnancy was determined in connection to their prepregnancy body mass index (BMI) and classified based on the Institute of Medicine guidelines. A standardized psychological scale was used to assess coping styles. The results showed that almost half of the participants did not meet the Institute of Medicine recommendations for weight gain during pregnancy. There were significant correlations between the styles of coping with stress and the GWG. Additionally, low correlations were indicated between emotional, avoidant, task-oriented coping styles and the age of pregnant women with GDM. Regression analysis showed that the stress-coping style that focused on emotions was the most predictive of overall weight gain. There is a need for a better understanding of psychological barriers in achieving the recommended GWG and potential limitations in providers’ interventions, particularly for GDM.
Different Pitch Configurations Constrain the Playing Tactics and the Creation of Goal Scoring Opportunities during Small Sided Games in Youth Soccer Players
Authors: González-Rodenas Joaquín , Aranda-Malavés Rodrigo , Tudela-Desantes Andrés , de Matías-Cid Pedro , Aranda Rafael
Published: October 2021

The aim of this study was to explore the tactical effects of different pitch configurations on the collective playing tactics and the creation of goal scoring opportunities (GSO) during small sided soccer games (SSG) in youth players. A total of 22 players performed a 7 vs. 7 + 1 floater (including goalkeepers) under three different pitch configurations (“Standard”, 53 × 38 m; “Long”, 63 × 32 m; and “Wide”, 43 × 47 m). Eleven tactical indicators related to the development and the end of the team possessions were evaluated by systematic observation. Friedman tests (non-parametric ANOVA for repeated measures) revealed that the long and wide configurations produced more counterattacks (p = 0.0028; ES = 0.3), higher offensive penetration (p = 0.007; ES = 0.41), and more GSO (p = 0.018; ES = 0.30) than the standard format. Regarding the creation of GSO, the wide configuration produced more assists in the form of crosses than the long and standard formats (p = 0.025; ES = 0.31), more utilization of wide subspaces to assist the final player (p = 0.022; ES = 0.35), more number of headers as the final action (p = 0.022; ES = 0.32), and less assists in the form of passes in behind the defense (p = 0.034; ES = 0.28), than the long configuration. The modulation of the pitch configuration during SSG produced different tactical demands, requiring players to implement different tactical solutions to create GSO.
The COVID-19 Pandemic and Intimate Partner Violence against Women in the Czech Republic: Incidence and Associated Factors
Authors: Plášilová Leona , Hůla Martin , Krejčová Lucie , Klapilová Kateřina
Published: October 2021

Intimate partner violence (IPV) is a burning social issue worldwide. According to global statistics, the incidence of IPV has increased during the COVID-19 pandemic due to restrictive measures (e.g., reduced social contacts, the need to stay at home often with a perpetrator in the same household). This study aims to provide data about the incidence of IPV and its associated factors during the COVID-19 pandemic in the Czech Republic. A representative online sample of 429 Czech women living with a partner at least 3 months before COVID-19 participated in the study. In an online interview, women reported IPV incidents 3 months before and during the first and second waves of the COVID-19 pandemic. Using non-parametric repeated measures ANOVA, a significant difference between the total IPV score and the given time periods was found. In addition, the results of the research showed a significant effect of the tension in the relationship with the partner, depression rate, and partner support on the total IPV score in the first and second wave of the COVID-19 pandemic. These results bring important insights into IPV incidence during the COVID-19 pandemic and suggest factors that might lead to an increased risk of IPV.
Mortality among People with Epilepsy: A Retrospective Nationwide Analysis from 2016 to 2019
Authors: Puteikis Kristijonas , Mameniškienė Rūta
Published: October 2021

We estimated age-adjusted mortality and investigated the dominant causes of death as well as comorbidities among people with epilepsy (PWE) in Lithuania, a country with frequent deaths from external causes. From 2016 to 2019, the age-adjusted rate of death among PWE in Lithuania was compared with mortality data in the general population. Each year of analysis, individuals who were diagnosed with epilepsy comprised a retrospective cohort. The standardized mortality ratio (SMR) of PWE varied from 2.93 (95% CI 2.78 to 3.07) to 3.18 (95% CI 3.02 to 3.34). PWE died at least one decade earlier than expected in the general population. The dominant causes of death were cardiovascular diseases (their proportion ranged from 44.8% to 49.3%), cancer (16.7% to 21.3%) and external causes of death (8.5% to 10.9%). The proportion of the latter decreased over time (r = −0.99, p = 0.01), whereas the SMR for external causes of death remained relatively constant. Epilepsy was the underlying cause of death in 163 cases (2.6%), and noted as a condition contributing to death in 1010 cases (15.9%). Cerebrovascular and cardiological conditions and dementia were the most frequent comorbidities among PWE before their death. Epilepsy-unrelated causes of death are relevant contributors to mortality among PWE. There is a need for PWE-oriented societal interventions to reduce the frequency of external deaths beyond the trend in the general population.
Complex Multimorbidity and Incidence of Long-Term Care Needs in Japan: A Prospective Cohort Study
Authors: Kato Daisuke , Kawachi Ichiro , Saito Junko , Kondo Naoki
Published: October 2021

Complex multimorbidity (CMM) has been proposed as a more nuanced concept of multimorbidity (MM). We sought to quantify the association of CMM and MM on the incidence of long-term care (LTC) needs in a cohort of older Japanese people. Our follow-up was based on a nationwide longitudinal cohort study of people aged over 65 years who were functionally dependent at baseline. Our outcome was incident LTC needs, based on certification under the Japanese LTC insurance scheme. We used both propensity score matching and inverse probability of treatment weights (IPTW) to compare individuals with and without MM versus CMM. A total of 38,889 older adults were included: 20,233 (52.0%) and 7565 (19.5%) adults with MM and CMM, respectively. In propensity-matched analyses, both MM (n = 15,666 pairs) and CMM (n = 7524 pairs) were statistically significantly associated with the six-year LTC insurance certification rate (MM, hazard ratio (HR) 1.07, 95% confidence interval (95%CI) 1.02–1.12; CMM, HR 1.10, 95%CI 1.04–1.16). Both MM and CMM were associated with a modest but statistically significantly higher rate of LTC insurance certification. These findings support the inclusion of multimorbidity in the assessment of LTC insurance needs, although the Japanese government currently has not adopted this.
Role of Human Primary Renal Fibroblast in TGF-β1-Mediated Fibrosis-Mimicking Devices
Authors: Hwang Seong-Hye , Lee Yun-Mi , Choi Yunyeong , Son Hyung Eun , Ryu Ji Young , Na Ki Young , Chin Ho Jun , Jeon Noo Li , Kim Sejoong
Published: October 2021

Renal fibrosis is a progressive chronic kidney disease that ultimately leads to end-stage renal failure. Despite several approaches to combat renal fibrosis, an experimental model to evaluate currently available drugs is not ideal. We developed fibrosis-mimicking models using three-dimensional (3D) co-culture devices designed with three separate layers of tubule interstitium, namely, epithelial, fibroblastic, and endothelial layers. We introduced human renal proximal tubular epithelial cells (HK-2), human umbilical-vein endothelial cells, and patient-derived renal fibroblasts, and evaluated the effects of transforming growth factor-β (TGF-β) and TGF-β inhibitor treatment on this renal fibrosis model. The expression of the fibrosis marker alpha smooth muscle actin upon TGF-β1 treatment was augmented in monolayer-cultured HK-2 cells in a 3D disease model. In the vascular compartment of renal fibrosis models, the density of vessels was increased and decreased in the TGF-β-treated group and TGF-β-inhibitor treatment group, respectively. Multiplex ELISA using supernatants in the TGF-β-stimulating 3D models showed that pro-inflammatory cytokine and growth factor levels including interleukin-1 beta, tumor necrosis factor alpha, basic fibroblast growth factor, and TGF-β1, TGF-β2, and TGF-β3 were increased, which mimicked the fibrotic microenvironments of human kidneys. This study may enable the construction of a human renal fibrosis-mimicking device model beyond traditional culture experiments.
Strengths and Weaknesses of Cell Synchronization Protocols Based on Inhibition of DNA Synthesis
Authors: Ligasová Anna , Koberna Karel
Published: October 2021

Synchronous cell populations are commonly used for the analysis of various aspects of cellular metabolism at specific stages of the cell cycle. Cell synchronization at a chosen cell cycle stage is most frequently achieved by inhibition of specific metabolic pathway(s). In this respect, various protocols have been developed to synchronize cells in particular cell cycle stages. In this review, we provide an overview of the protocols for cell synchronization of mammalian cells based on the inhibition of synthesis of DNA building blocks—deoxynucleotides and/or inhibition of DNA synthesis. The mechanism of action, examples of their use, and advantages and disadvantages are described with the aim of providing a guide for the selection of suitable protocol for different studied situations.
Weak Interactions of the Isomers of Phototrexate and Two Cavitand Derivatives
Authors: Preisz Zsolt , Nagymihály Zoltán , Kollár László , Kálai Tamás , Kunsági-Máté Sándor
Published: October 2021

The interactions of two conformers of newly synthesized photoswitchable azobenzene analogue of methotrexate, called Phototrexate, with two cavitand derivatives, have been investigated in dimethyl sulfoxide medium. Photoluminescence methods have been applied to determine the complex stabilities and the related enthalpy and entropy changes associated to the complex formation around room temperature. Results show opposite temperature dependence of complex stabilities. The structure of the upper rims of the host molecules and the reordered solvent structure were identified as the background of the opposite tendencies of temperature dependence at molecular level. These results can support the therapeutic application of the photoswitchable phototrexate, because the formation of inclusion complexes is a promising method to regulate the pharmacokinetics of drug molecules.
The Sphingosine Kinase 2 Inhibitor ABC294640 Restores the Sensitivity of BRAFV600E Mutant Colon Cancer Cells to Vemurafenib by Reducing AKT-Mediated Expression of Nucleophosmin and Translationally-Controlled Tumour Protein
Authors: Grbčić Petra , Eichmann Thomas O. , Kraljević Pavelić Sandra , Sedić Mirela
Published: October 2021

Vemurafenib (PLX4032), small-molecule inhibitor of mutated BRAFV600E protein, has emerged as a potent anti-cancer agent against metastatic melanoma harboring BRAFV600E mutation. Unfortunately, the effect of PLX4032 in the treatment of metastatic BRAF mutated colorectal cancer (CRC) is less potent due to high incidence of fast-developing chemoresistance. It has been demonstrated that sphingolipids are important mediators of chemoresistance to various therapies in colon cancer. In this study, we will explore the role of major regulators of sphingolipid metabolism and signaling in the development of resistance to vemurafenib in BRAF mutant colon cancer cells. The obtained data revealed significantly increased expression levels of activated sphingosine kinases (SphK1 and SphK2) in resistant cells concomitant with increased abundance of sphingosine-1-phosphate (S1P) and its precursor sphingosine, which was accompanied by increased expression levels of the enzymes regulating the ceramide salvage pathway, namely ceramide synthases 2 and 6 and acid ceramidase, especially after the exposure to vemurafenib. Pharmacological inhibition of SphK1/SphK2 activities or modulation of ceramide metabolism by exogenous C6-ceramide enhanced the anti-proliferative effect of PLX4032 in resistant RKO cells in a synergistic manner. It is important to note that the inhibition of SphK2 by ABC294640 proved effective at restoring the sensitivity of resistant cells to vemurafenib at the largest number of combinations of sub-toxic drug concentrations with minimal cytotoxicity. Furthermore, the obtained findings revealed that enhanced anti-proliferative, anti-migratory, anti-clonogenic and pro-apoptotic effects of a combination treatment with ABC294640 and PLX4032 relative to either drug alone were accompanied by the inhibition of S1P-regulated AKT activity and concomitant abrogation of AKT-mediated cellular levels of nucleophosmin and translationally-controlled tumour protein. Collectively, our study suggests the possibility of using the combination of ABC294640 and PLX4032 as a novel therapeutic approach to combat vemurafenib resistance in BRAF mutant colon cancer, which warrants additional preclinical validation studies.