bluuebunny/crossref_metadata_2025 huggingface dataset:
PENGARUH PELAYANAN DAN SISTEM MUDHARABAH TERHADAP KEPUTUSAN NASABAH MENABUNG
Authors: Siti hariza  , Mohammad Usman
Published: September 2024

BMT Syariah Mawaddah Karang Penang Branch Sampang Madura with service activity programs with the mudharabah system in customer decisions to save there is a significant effect simultaneously, but partially only the mudharabah system has a significant effect.The purpose of this study is to determine the effect of the service and the mudharabah system on the customer's decision to save simultaneously, to determine the effect of the service and the mudharabah system to the customer's decision to save partially, to determine the influence of the dominant variable from the independent variable that affects the independent variable. This research is quantitative research with data analysis technique using multiple linear regression. The data used in the form of primary data through the distribution of questionnaires to customers of BMT Syariah Mawaddah Karang Penang Branch Sampang Madura in 2021. The sample used in this study was 83 respondents. The results of this study indicate that (1) the service and the mudharabah system simultaneously have a significant effect on the customer's decision to save by 0.050. (2) Service partially has no significant effect on the customer's decision to save by 0.282. (3) the mudharabah system partially has a significant effect on the customer's decision to save by 0.083
PELUANG DAN TANTANGAN PENGEMBANGAN UMKM HALAL DI INDONESIA
Authors: Zainorrahman  , Reza Zulfikri Robby
Published: September 2024

Artikel ini mencoba menjelaskan Peluang dan Tantangan Pengembangan UMKM di industri UMKM halal di Indonesia, mengingat jumlah konsumen Muslim yang potensial. Pentingnya pengetahuan tentang perilaku konsumen muslim Indonesia perlu agar UMKM halal Indonesia bisa memaksimalkan pasar domestik dan sekaligus ekspor. Potensi konsumen muslim tidak hanya di Indonesia, negara-negara Teluk dan negara Asia Tenggara lainnya dapat menjadi tujuan ekspor produk industri halal Indonesia. Adapun metode penelitian yang dilakukan oleh peneliti adalah Library Research (Studi Kepustakaan). Hasil dari artikel ini menunjukkan bahwa terdapat beberapa hal yang menjadi Peluang dan Tantangan Pengembangan UMK di industri UMKM halal di Indonesia mulai dari Aspek Demografi, Market, Ekonomi Digital, Pendanaan, dan juga Sertifikat Halal bagi UMKM di Indonesia.
PENGARUH ISLAMIC MARKETING MIX TERHADAP LOYALITAS PELANGGAN DALAM KONSUMSI BAJU MUSLIM PADA E- COMMERCE
Authors: Dawimatus sholihah
Published: September 2024

This Study aims to analyze and empirically test the variables in the study that have been formulated in the problem formulation classified as explanatory research, namely whether there is an influence between customer value (X1), Cost to Customer (X2), Communication (X3), Convenience (X4) on customer satisfaction (Z) and customer loyalty (Y). Sampling in this study using nonprobability sampling, and the form of sampling using purposive sampling where the determination of the sampel by selecting the sample among the population according to what the researcher wants (objectives or problem in the study), that is, some people in regency of Jember who subscribe to online shopping at Shopee. Data analysis was performed using multiple regression Analysis developed with path.
PENERAPAN CONTENT MARKETING TERHADAP MINAT PEMBELI DI TUKU-TUKU STORE BONDOWOSO
Authors: Nuril Qomariah  , Wildatul Jannah  , Haqiqotus Sa'adah
Published: September 2024

Tujuan dari penelitian ini adalah untuk menyelidiki bagaimana Penerapan Content terhadap Minat Beli Konsumen di Tuku-tuku Store Bondowoso. Penelitian ini menggunakan metode deskriptif kualitatif, yang mana merupakan peneliian yang di lakukan dengan menggali data langsung dari nara sumber, objek ataupun lokasi penelitian. Hasil penelitian menunjukkan bahwa, Content Marketing memiliki pengaruh positif terhadap Minat Beli Konsumen,Konsumen tertarik karena content yang dibuat dapat menyajikan kebutuhan ataupun kepentingan seperti yang mereka cari, Survei terhadap responden menunjukkan mayoritas dari mereka sangat setuju dengan beberapa indikator, seperti “Mudah Dipahami dan Up to date” yang menunjukkan bahwa pemasar menyediakan konten yang mudah dipahami dan dimengerti oleh konsumen dan menyediakan konten yang kekinian atau Up to date.  Oleh karena itu, penelitian ini memberikan pemahaman yang lebih baik tentang bagaimana Content Marketing dapat meningkatkan Minat Beli Konsumen di Tuku-tuku Store Bondowoso.
DAMPAK PENGUMUMAN PENERBITAN SUKUK, OBLIGASI KONVENSIONAL TERHADAP RETURN SAHAM PERUSAHAAN
Authors: Fariroh Isnain Badi' , Kusuma Wardana Guntur , Nur Holis Muhammad
Published: September 2024

Penelitian ini bertujuan untuk mengetahui pengaruh dari penerbitan obligasi dan sukuk terhadap return saham yang diwakili oleh variabel ukuran perusahaan, leverage, ukuran obligasi atau sukuk dan perubahan laverage. Penelitian ini menggunakan metode kuantitatif dengan pendekatan event study. Populasi dalam penelitian ini sebanyak 117 perusahaan dan sampel penelitian sebanyak 21 perusahaan. Data diperoleh dari laporan keuangan yang diperoleh dari Bursa Efek Indonesia. Metode analisis data menggunakan model regresi linear berganda. Adapun hasil penelitian ini adalah tidak terdapat pengaruh variabel ukuran perusahaan, leverage, ukuran obligasi/ sukuk dan perubahan laverage terhadap return saham.
PERAN MAHASISWA KKN DALAM MENINGKATKAN MINAT BELAJAR SISWA MELALUI MEDIA PEMBELAJARAN DI SD GMIM RAANAN BARU
Authors: Supit Sugijanti , Palar Yolanda , Pangemanan Juwita , Hinonaung Gratia , Mangalo Yuliana , Makalisang Yudian , Tinengke Yudince I , Bulasing Maruanto , Rading Elsa , Makawalengke Yeremia
Published: September 2024

The problem that still often occurs in the world of education, especially at the elementary school level, is the lack of interest in learning from students. This is caused by the limitations of learning media. With these constraints, the researcher aims to play a role in increasing students' interest in learning at GMIM Raanan Baru Elementary School through learning media. This study uses qualitative research methods, using observation techniques. This observation technique is carried out by direct observation of the situation in the field. The location of this research was SD GMIM Raanan Baru, West Motoling district. This research is a form of KKN student service during the KKN period from 6 February – 8 March 2023. With the role of students through the service carried out, students at GMIM Raanan Baru Elementary School have an increased interest in learning.
Strategi Pemberdayaan Ekonomi Jemaat Sebagai Aksi Pastoral
Authors: Mangintiu Meylan , Nyortetma Devence , Salindeho Sri Apria , Bambung Charolin , Papehasen Christian , Amping Eunike , Inaku Rahel , Manggiwu Sindy , Biala Trisakti , Binilang Yanly , Hender Solistiyo , Piandatu Natasya
Published: September 2024

By exploring various plans that are prepared as an integral part of the church's pastoral action, through approaches that can improve the economic welfare of the congregation and practical spiritual support from the church. In several sections it can be seen how the church plays an active role in encouraging economic independence which strengthens community life and improves the quality of life of the congregation, and we need to know that the factor that drives congregational independence is the pastoral role in the community service program that has been implemented, so it is necessary for us to understand how step by step the pastoral service strategy is implemented at GMIST Wori Congregation in the "Community Service" (PKM) activity. In general, pastoral care is a fundamental aspect of church life that involves spiritual, emotional and social support for the congregation. A pastoral approach focuses on deep interpersonal relationships, supporting individuals in facing life's challenges, and helping them find meaning and purpose in the context of the Christian faith. What is discussed in the pastoral care program is so interesting, that there are ideas that are formulated related to teaching about economic empowerment, which are often forgotten and rarely discussed, so that this becomes a small part of what causes divisions within the congregation without realizing it. So we will examine how pastoral service can be used to empower the congregation's economy, with the title "Congregation Economic Empowerment Strategy as Church Pastoral Action".
Inklusivitas Dalam Gereja : Pendekatan Pastoral Konseling Bagi Jemaat Dengan Disabilitas
Authors: Bokko Lanny Sonia , Luma Subaedah
Published: September 2024

This article explores the concept of church inclusivity towards people with disabilities with a focus on the role and approach of pastoral counseling. Inclusivity is defined as the recognition and appreciation of diversity, including individuals with disabilities. The concept of pastoral counseling is discussed, emphasizing the importance of the church to provide support and approaches from the emotional, spiritual, and facilities support on the needs of congregants with disabilities. This research emphasizes the importance of disability inclusivity in the church context, with the important role of pastoral counseling in supporting individuals with disabilities to live fully and meaningfully in the community without feeling neglected by the church.
PENYEMBUHAN HOLISTIK DALAM PERSPEKTIF GMIST SEBAGAI STRATEGI PASTORAL KONSELING BAGI PASIEN DI RUMAH SAKIT DAERAH LIUN KENDAGE TAHUNA
Authors: Pratiwi Anggraini Makansing  , Olivia Cherly Wuwung  , Yohan Brek
Published: September 2024

Holistic healing is a healing method that takes into account different aspects such as spiritual, social, in addition to medical and psychological aspects. Pastoral counseling helps the healing process holistically, more specifically the spiritual aspect of the human being. Liun Kendage Tahuna Regional Hospital has not realized how important holistic healing is for patients with pastoral counseling strategies. The method used in this study is a descriptive qualitative that seeks to describe a social phenomenon, where the data collected is first described, then analyzed and formulated. The purpose of this study is to show how important the role of pastoral counseling for patients is in realizing holistic healing from the perspective of GMIST.
Meningkatkan Kualitas Pelayanan Pastoral Melalui Penguatan Spritualitas Di GMIST Pusirungang Gangga Satu
Authors: Kota Agnes , Adelin Bawues  , Anatasia Pangku  , Brilian Pondaag  , Feiby Feronika Kawangung  , Gloria Santa Klara  , Kesya Taarae  , Kristiani Makahingide  , Pingky Pedati  , Selna Bawental  , Suzzet Parauba  , Yusita Y Bulenoh
Published: September 2024

The PKM program at GMIST Pusirungang Gangga Satu, led by 12 active students from the Institute of Christian Studies in Manado, aimed to address several issues within the community that required pastoral care. The program employed a qualitative descriptive research method, involving data collection through observation, interviews, and documentation. The students observed that the community faced several challenges that needed to be addressed through pastoral care. To address these issues, the students organized a seminar for the pastoral care providers at GMIST Pusirungang Gangga Satu, focusing on strengthening spiritualities to enhance the quality of service. The seminar aimed to improve the resolution of issues within the community through pastoral care.
Menjinakan Kecemasan Kesehatan Online: Peran Pastoral Konseling Dalam Mengatasi Cyberchondria
Authors: Lanongbuka Amartya Lovelin , Takaendengan Arni Elsny
Published: September 2024

Cyberchondria is someone who tends to search excessively for health information on the internet and feels anxious or worried about their health condition based on the information they find. Previous research has provided evidence that health information seeking has a relationship with anxiety, where individuals with higher levels of anxiety will generally browse and search for health information via the internet more often. One of the help services that can be done to overcome the anxiety of cyberchondria sufferers holistically is pastoral counseling services. The purpose of this study is to describe the role of pastoral counseling in overcoming Cyberchondria. The results of this study show that pastoral counseling has an important role in helping individuals overcome anxiety arising from cyberchondria. The pastoral approach offers emotional support, spiritual guidance, and assistance in finding meaning and purpose in life in the context of the health experience by reviewing pastoral functions as supportive, namely guiding, empowering, and reconciling. While pastoral counseling provides important support, more specific treatments such as Cognitive Behavioral Therapy (CBT), psychodynamic therapy, or group therapy may be required from mental health professionals to address cyberchondria in greater depth.
PELAYANAN PASTORAL KONSELING OLEH PELAYAN KHUSUS KEPADA ISTRI YANG TELAH BERCERAI
Authors: Opit Preysilia Kirey Eleison , Wagiu Meily M. , Brek Yohan
Published: September 2024

Divorce is something that is contrary to the teachings of the Bible, but in almost every church there are cases of divorce that occur. Divorce creates problems in the life of the congregation and if not handled well it will have negative impacts. The church needs to highlight the problem of divorce and find solutions to address existing problems, for example by providing pastoral counseling services to congregation members who have divorced. Women are still often considered as weak figures and are often victims in the household, there are many women who receive inappropriate treatment and become victims of violence. Pastoral counseling services can be used as a tool that can help churches provide assistance to congregations who are in trouble.
Dampak Penggunaan Gadget Berlebihan Terhadap Kesehatan Fisik dan Mental Remaja
Authors: Tengkue Anggreini Angelina , Manein Adika Putri , Angelica Elisabeth  , Ilat Irene Preisilia
Published: September 2024

Arikel ini dibuat dengan tujuan untuk mengetahui tentang dampak dari penggunaan gadget secara berlebihan terhadap kesehatan fisik dan mental remaja. Penelitian ini dilakukan dengan dilatar belakangi oleh keadaan yang ada di saat ini yang dimana perkembangan sudah semakin pesat terutama dalam hal perkembangan teknologi. Dimana teknologi sudah masuk dalam aspek kehidupan manusia dengan berbagai kemudahan yang diberikan. Terutama di kalangan remaja, gadged menjadi suatu hal yang sangat menarik, untuk itu banyak remaja yang memilih menghabiskan waktu mereka dengan gadged dari pada melakukan aktivitas lainnya. Berkaitan dengan ini maka sangat diperlukan untuk memberikan edukasi kepada remaja tentang dampak dari penggunaan gadget yang berlebihan bagi mereka. Karena gadget jika penggunaannya sudah tidak sesuai maka akan berdampak buruk pada remaja baik secara fisik maupun mental. Metode penelitian yang digunakan adalah metode studi kepustakaan atau kajian kualitatif deskriptif berbasis literatur yang berupa buku maupun jurnal ilmiah, dengan teknik pengumpulan datanya yaitu melalui analisis isi litaratur. Hasil dari penelitian ini yaitu penggunaan gadget secara tidak tepat dan berlebihan ini berdampak pada kesehatan remaja, yang jika dilihat dari pengaruh terhadap kesehatan fisik itu bisa mengakibatkan obesitas, gangguan tidur, sakit kepala, bahkan sampai kepada kanker otak sementara untuk dampak secara mental itu bisa membuat remaja mengalami stres, depresi, gangguan kecemasan, penurunan motivasi belajar dan ketergantungan terhadap gadget.
Aspectos clínicos e terapêuticos da parvovirose em cães naturalmente infectados: relato de 37 casos
Authors: Silva Thayná Emília Oliveira , Jacinto Judson Carlos Marques , De Melo Ubiratan Pereira , Ferreira Cintia
Published: September 2024

A parvovirose canina é uma doença viral infectocontagiosa, causada pelo parvovírus canino (CPV), e apresenta grande importância para a medicina veterinária devido a sua alta morbidade e mortalidade. Este trabalho teve como objetivo descrever os aspectos clínicos e terapêuticos da parvovirose em cães naturalmente infectados atendidos em um centro clínico privado na cidade de Macaíba, Rio Grande do Norte, Brasil. Os dados foram obtidos a partir dos registros de atendimento clínico realizados durante o período de setembro de 2022 a setembro de 2023. Para a triagem inicial, utilizou-se como critério de inclusão histórico de vômito ou diarreia. O segundo critério de inclusão foi a realização de teste sorológico rápido para parvovirose e/ou permanência do animal internado para tratamento. De 87 prontuários previamente selecionados, apenas 37 permaneceram no estudo. Todos os animais foram submetidos ao mesmo protocolo terapêutico durante o período de internamento. Dos cães positivos, 40,5% eram sem raça definida (SRD), enquanto 24,3% eram da raça Pitbull e 16,2% da raça Pinscher; outras raças corresponderam a 18,9% dos casos clínicos. Observou-se que 100% dos cães apresentavam quadro de leucopenia e 59,4% apresentavam anemia. A taxa de alta médica foi de 94,7%,corroborando a eficácia da terapêutica intensiva aos portadores do parvovírus.
Inclusive, Exclusive and Hierarchical Atlas of NFATc1+/PDGFR-α+ Cells in Dental and Periodontal Mesenchyme
Authors: Yang Xue , Han Chuyi , Yu Changhao , Zhou Bin , Ye Ling , Li Feifei , Yu Fanyuan
Published: September 2024

Platelet-derived growth factor receptor alpha (PDGFR-α) activity is crucial in the process of dental and periodontal mesenchyme regeneration facilitated by autologous platelet concentrates (APCs), such as platelet-rich fibrin (PRF), platelet-rich plasma (PRP) and concentrated growth factors (CGF), as well as by recombinant PDGF drugs. However, it is largely unclear about the physiological patterns and cellular fate determinations of PDGFR-α
+
cells in the homeostasis maintaining of adult dental and periodontal mesenchyme. We previously identified NFATc1 expressing PDGFR-α
+
cells as a subtype of skeletal stem cells (SSCs) in limb bone, but their roles in dental and periodontal remain unexplored. To this end, in the present study we investigated the spatiotemporal atlas of NFATc1
+
and PDGFR-α
+
cells residing in dental and periodontal mesenchyme, their capacity for progeny cell generation, and their inclusive, exclusive and hierarchical relations in homeostasis. We utilized CRISPR/Cas9-mediated gene editing to generate two dual recombination systems, which were
Cre/loxP
-
Dre/Rox
combined intersectional and exclusive reporters respectively, to concurrently demonstrate the inclusive, exclusive, and hierarchical distributions of NFATc1
+
and PDGFR-α
+
cells and their lineage commitment. By employing the state-of-the-art transgenic lineage tracing techniques in cooperating with tissue clearing-based advanced imaging and three-dimensional slices reconstruction, we systematically mapped the distribution atlas of NFATc1
+
and PDGFR-α
+
cells in dental and periodontal mesenchyme and tracked their
in vivo
fate trajectories. Our findings extend current understanding of NFATc1
+
and PDGFR-α
+
cells in dental and periodontal mesenchyme homeostasis, and furthermore enhance our comprehension of their sustained therapeutic impact for future clinical investigations.
Vangl2 suppresses NF-κB signaling and ameliorates sepsis by targeting p65 for NDP52-mediated autophagic degradation
Authors: Lu Jiansen , Zhang Jiahuan , Jiang Huaji , Hu Zhiqiang , Zhang Yufen , He Lian , Yang Jianwu , Xie Yingchao , Wu Dan , Li Hongyu , Zeng Ke , Tan Peng , Xiao Qingyue , Song Zijing , Pan Chenglong , Bai Xiaochun , Yu Xiao
Published: September 2024

Van Gogh-like 2 (Vangl2), a core planar cell polarity component, plays an important role in polarized cellular and tissue morphology induction, growth development, and cancer. However, its role in regulating inflammatory responses remains elusive. Here, we report that Vangl2 is upregulated in patients with sepsis and identify Vangl2 as a negative regulator of The nuclear factor-kappaB (NF-κB) signaling by regulating the protein stability and activation of the core transcription component p65. Mice with myeloid-specific deletion of Vangl2 (Vangl2ΔM) are hypersusceptible to lipopolysaccharide (LPS)-induced septic shock. Vangl2-deficient myeloid cells exhibit enhanced phosphorylation and expression of p65, therefore, promoting the secretion of proinflammatory cytokines after LPS stimulation. Mechanistically, NF-κB signaling-induced-Vangl2 recruits E3 ubiquitin ligase PDLIM2 to catalyze K63-linked ubiquitination on p65, which serves as a recognition signal for cargo receptor NDP52-mediated selective autophagic degradation. Taken together, these findings demonstrate Vangl2 as a suppressor of NF-κB-mediated inflammation and provide insights into the crosstalk between autophagy and inflammatory diseases.
Language experience shapes predictive coding of rhythmic sound sequences
Authors: Morucci Piermatteo , Nara Sanjeev , Lizarazu Mikel , Martin Clara , Molinaro Nicola
Published: September 2024

Perceptual systems heavily rely on prior knowledge and predictions to make sense of the environment. Predictions can originate from multiple sources of information, including contextual short-term priors, based on isolated temporal situations, and context-independent long-term priors, arising from extended exposure to statistical regularities. While the effects of short-term predictions on auditory perception have been well-documented, how long-term predictions shape early auditory processing is poorly understood. To address this, we recorded magnetoencephalography data from native speakers of two languages with different word orders (Spanish: functor-initial vs Basque: functor-final) listening to simple sequences of binary sounds alternating in duration with occasional omissions. We hypothesized that, together with contextual transition probabilities, the auditory system uses the characteristic prosodic cues (duration) associated with the native language’s word order as an internal model to generate long-term predictions about incoming non-linguistic sounds. Consistent with our hypothesis, we found that the amplitude of the mismatch negativity elicited by sound omissions varied orthogonally depending on the speaker’s linguistic background and was most pronounced in the left auditory cortex. Importantly, listening to binary sounds alternating in pitch instead of duration did not yield group differences, confirming that the above results were driven by the hypothesized long-term ‘duration’ prior. These findings show that experience with a given language can shape a fundamental aspect of human perception – the neural processing of rhythmic sounds – and provides direct evidence for a long-term predictive coding system in the auditory cortex that uses auditory schemes learned over a lifetime to process incoming sound sequences.
Lymphoid origin of intrinsically activated plasmacytoid dendritic cells in mice
Authors: Araujo Alessandra Machado , Dekker Joseph D , Garrison Kendra , Su Zhe , Rhee Catherine , Hu Zicheng , Lee Bum-Kyu , Osorio Daniel , Lee Jiwon , Iyer Vishwanath R , Ehrlich Lauren IR , Georgiou George , Ippolito Gregory , Yi Stephen , Tucker Haley O
Published: September 2024

We identified a novel mouse plasmacytoid dendritic cell (pDC) lineage derived from the common lymphoid progenitors (CLPs) that is dependent on expression of Bcl11a. These CLP-derived pDCs, which we refer to as ‘B-pDCs’, have a unique gene expression profile that includes hallmark B cell genes, normally not expressed in conventional pDCs. Despite expressing most classical pDC markers such as SIGLEC-H and PDCA1, B-pDCs lack IFN-α secretion, exhibiting a distinct inflammatory profile. Functionally, B-pDCs induce T cell proliferation more robustly than canonical pDCs following Toll-like receptor 9 (TLR9) engagement. B-pDCs, along with another homogeneous subpopulation of myeloid-derived pDCs, display elevated levels of the cell surface receptor tyrosine kinase AXL, mirroring human AXL+ transitional DCs in function and transcriptional profile. Murine B-pDCs therefore represent a phenotypically and functionally distinct CLP-derived DC lineage specialized in T cell activation and previously not described in mice.
Potential acetylcholine-based communication in honeybee haemocytes and its modulation by a neonicotinoid insecticide
Authors: Pamminger Tobias , Basley Kate , Goulson Dave , Hughes William O. H.
Published: September 2024

There is growing concern that some managed and wild insect pollinator populations are in decline, potentially threatening biodiversity and sustainable food production on a global scale. In recent years, there has been increasing evidence that sub-lethal exposure to neurotoxic, neonicotinoid pesticides can negatively affect pollinator immunocompetence and could amplify the effects of diseases, likely contributing to pollinator declines. However, a direct pathway connecting neonicotinoids and immune functions remains elusive. In this study we show that haemocytes and non-neural tissues of the honeybee Apis mellifera express the building blocks of the nicotinic acetylcholine receptors that are the target of neonicotinoids. In addition, we demonstrate that the haemocytes, which form the cellular arm of the innate immune system, actively express choline acetyltransferase, a key enzyme necessary to synthesize acetylcholine. In a last step, we show that the expression of this key enzyme is affected by field-realistic doses of clothianidin, a widely used neonicotinoid. These results support a potential mechanistic framework to explain the effects of sub-lethal doses of neonicotinoids on the immune function of pollinators.
Infection Control Awareness and Practices among Dental Students in Gujarat: A Questionnaire Based Cross-sectional Study
Authors: Rami Diptesh Sureshbhai , Chauhan Chirag , Sutaria Bhagyashree Shreyansh
Published: September 2024

Introduction: In recent years, medical advancements have led to significant progress in infection control, reducing risks in healthcare settings. However, Healthcare-Associated Infections (HAIs) remain a major global concern, affecting millions of patients each year and increasing morbidity, mortality, and healthcare costs. Dental clinics are susceptible environments for disease transmission, exposing dentists to blood-borne pathogens. Vigilance and strict infection control measures are essential in dental settings to protect both practitioners and patients. Implementing universal precautions in dental schools is crucial for controlling cross-infection, as it ensures that students are equipped with the necessary knowledge and attitudes for effective infection control. Aim: To evaluate the knowledge, attitudes, and practices of infection control among undergraduate dental students in the state of Gujarat. Materials and Methods: A cross-sectional questionnaire study involving 229 undergraduate dental students assessed knowledge and attitudes towards infection control at Ahmedabad Dental College and Hospital in October 2020. Approval was obtained, and a structured questionnaire adapted from previous literature was utilised. Rigorous content validation and analysis were conducted, revealing strong internal consistency. Data collection was conducted online and analysed using Chi-square tests for significance. Results: In the study, 185 (80.7%) of the respondents were female, and the majority of subjects were “Interns” (81, or 35.4%). The study shows significant gender differences in Hepatitis B vaccination (p=0.038), with both genders mostly vaccinated. However, attitudes and practices towards infection control did not significantly differ by gender. The study also reveals associations between the year of study and Hepatitis B vaccination (p=0.013), as well as attitudes and practices related to infection control. Notably, a considerable proportion of students across all years did not use protective eyewear during aerosol procedures. Overall, the study highlights awareness of infection control, with some variations by gender and year of study. Conclusion: The participants in this study demonstrated good knowledge and a positive attitude regarding infection control protocols. However, the practice of infection control methods varied, and consistency was not found.
Unravelling Anaesthetic Challenges in Patient with Diffuse Systemic Sclerosis: A Case Report
Authors: . Madhu , Jain Shally , Kumar Vikas , Das Anurag , Lakhanpal Harsh
Published: September 2024

Systemic sclerosis or scleroderma is an uncommon autoimmune condition with a global incidence of 8 to 56 new cases per million per year, which commences from skin and progresses to affect multiple systems in the body. It is marked by abnormalities in blood vessels, sclerosis of connective tissues and atrophy of skin and internal organs. The systemic sclerosis treatment depends on the disease manifestation and are usually treated with vasodilators (for vasculopathy improvement and prevention of Raynaud’s phenomenon), prostacyclin analogues (for the prevention of Raynaud’s phenomenon refractory to oral vasodilators), immunosuppressants like methotrexate, cyclophosphamide, mycophenolate mofetil, low dose corticosteroids (for the treatment of skin hardening, interstitial lung disease and inflammatory arthritis) and antifibrotics like endothelin receptor antagonists (for the treatment of pulmonary artery hypertension). Avascular necrosis in systemic sclerosis can arise as a result of the macrovascular and microvascular effects of vasculitis and corticosteroid therapy. The multisystem involvement of systemic sclerosis can impact every aspect of anaesthetic care especially airway management. During perioperative management, numerous systemic manifestations like pulmonary artery hypertension, interstitial lung disease and cardiac arrhythmia should be considered. The regional anaesthesia serves as a safe alternative to general anaesthesia and useful adjunct in the management of postoperative pain, but can be technically challenging. This case report described a 61-year-old female patient who had a history of systemic sclerosis for past 25 years and was scheduled for a total hip replacement due to avascular necrosis and secondary osteoarthritis of the left hip. The patient was having difficult cannulation, interstitial lung disease and anticipated difficult airway because of microstomia, limited mouth opening and limited flexion and extension at atlantooccipital joint. But the patient was successfully managed with combined spinal epidural anaesthesia, which provided effective pain control and minimised the perioperative risk associated with general anaesthesia.
Prevalence and Severity of Pulmonary Hypertension in Patients with Chronic Kidney Disease Stage 4 and 5: A Cross-sectional Study
Authors: Dhadwad Jagannath , Chitnis Anish
Published: September 2024

Introduction: Chronic Kidney Disease (CKD) is a multifaceted medical condition characterised by the gradual loss of kidney function over time, often leading to a myriad of complications affecting various organ systems in the body. Among these complications, Pulmonary Hypertension (PH) has emerged as a significant yet under-recognised co-morbidity, particularly in patients with advanced CKD stages 4 and 5. PH is defined by elevated mean Pulmonary Arterial Pressure (PAP) and increased Pulmonary Vascular Resistance (PVR). Understanding the intricate relationship between CKD and PH is essential for effective management and improved patient outcomes. Aim: To study the prevalence and severity of PH in patients with CKD stages 4 and 5 and to explore the relationship between PH and co-morbidities such as Type 2 Diabetes Mellitus (DM2) and systemic Hypertension (HTN) in these patients. Materials and Methods: This cross-sectional analysis was performed in the Department of General Medicine at Dr. D.Y. Patil Medical College, Hospital and Research Centre, Dr. D. Y. Patil Vidyapeeth (Deemed to be University), Pune, Maharashtra, India on 100 cases from September 2022 to May 2024. The patients were divided into CKD stages 4 and 5 based on the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation. PH was diagnosed based on 2D Echocardiography (ECHO) and categorised into mild, moderate and severe. Quantitative variables were compared using an unpaired t-test between CKD stages 4 and 5. Qualitative variables were compared using the Chi-square or Fisher’s-exact test. Results: The mean age of the study participants was 56.25±12.45 years. A total of 66% of the study participants were diagnosed with stage 4 CKD. In this study, a statistically non significant association was seen between the stages of CKD and the grades of PH (p-value=0.74). No significant association was found between diabetes and PH (p-value=0.97) in CKD stages 4 and 5. The median Pulmonary Artery Systolic Pressure (PASP) was found to be higher in non diabetics and non hypertensives in CKD stages 4 and 5 and this was statistically significant (p<0.0001). Conclusion: The prevalence of PH among CKD patients was 78%. However, the severity of PH was not found to be significantly associated with the severity of CKD. Co-morbidities were present in a substantial number of cases, but no significant correlation was identified.
Collagen-based Mesh in the Treatment of Posthernioplasty Mesh Infection in Ventral Hernias: A Case Series
Authors: Narayan Naveen , Rajesh KN , Shivannaiah Chethan , Gowda Suhas N
Published: September 2024

Posthernioplasty mesh infection in ventral hernias presents significant clinical challenges, including increased morbidity and prolonged treatment courses. The use of Surgicoll-Mesh® (collagen-based) in the management of infected posthernioplasty abdominal wounds has yet to be explored. It is thought to offer potential advantages in reducing infection rates and promoting tissue integration. Here, a case series showcasing the successful treatment of three patients with infected posthernioplasty abdominal wounds using Surgicoll-Mesh® to cover the defects is presented. All three cases demonstrated excellent outcomes, including resolution of infection, effective wound healing and no recurrence of hernias. This series highlights the potential of Surgicoll-Mesh® in managing complex abdominal wall infections.
Diversity and Utilization of Forestry Resources for Enhancing Household Food Security in the Leh Himalaya, India
Authors: Khan F.A. Shah , Islam M.A. , Gatoo A.A. , Bhat G.M. , Parrey A.A. , Bakshi M.R. , Atta Ummar , Chandramolly
Published: September 2024

Food resources extracted from forestry landscapes enhance the quality of diets, improve health care, and ensure income diversification for local communities in developing countries. This paper explores the diversity, seasonality, distribution, mode of use, frequency of use, and reliance of forestry food resources on livelihoods in the Leh Himalaya. Data were collected from 185 sample families that were selected from five blocks and nine villages using a multi-stage random sampling procedure. Descriptive statistics were applied to the data analysis. Results revealed that 37 forestry food resources were harvested from 27 herbs, 3 shrubs, and 3 trees belonging to 28 genera and 19 families, and consumed as vegetables (15), fruits (5), dye or flavour (4), pot herb (4), salad (3), beverage (2), sauce (2), condiment (1), oil seeds (1), flatbread (1), sour (1), and tantur (1). Over 63.18% of sample households extracted and utilised all the forestry food resources extremely often for cash earnings and sustenance during the peak period. Forestry food resources constitute a key source of food, nutrition, health care, subsistence, cash income, and safety nets. This study gives insights to promote the conservation of forestry foods, develop management strategies that could be harmonised with rural development, poverty alleviation, food security, and livelihood sustainability for rural communities in Leh Himalaya, and accordingly design useful policy implications.
Analysis of Functional Properties of Fuzzy \(\tilde{L}\) \(^p\Omega\) Spaces
Authors: MAZONI Grace NKWESE , KASOKI Clara PALUKU , LONDJIRINGA Emilien LORANU , ENGOMBANGI Jonathan OPFOINTSHI , BINENE Camile LIKOTELO
Published: September 2024

This paper proposes a study of fuzzy \(\tilde{L}\)p (Ω) spaces, incorporating functions with triangular fuzzy coefficients. These fuzzy functional spaces provide a better adaptation to fuzzy or imprecise functions. We establish the theoretical foundations of these spaces by examining key functional properties, such as the fuzzy scalar product and the fuzzy norm.
To do this, we checked the bilinearity, symmetry, positivity, homogeneity and triangular inequality in a fuzzy environment and in the presence of functions whose coefficients are triangular fuzzy numbers, by the \(\alpha\) -cut Dubois and Prade approach.
The aim of this paper is to address observations identified in the existing literature, where some functional properties of \(\tilde{L}\)p (Ω) fuzzy spaces are often addressed in a too general manner, without specifying the types of fuzzy functions. This study aims to provide a more detailed and rigorous analysis, thus enriching mathematical understanding and paving the way for practical applications in diverse fields such as: fuzzy differential equations, artificial intelligence, information processing, and decision making in uncertain environments.
Assessment of Bacterial Biocontrol agents Formulations against Anthracnose of Cashew (Anacardium occidentale L.) in Côte d’Ivoire
Authors: Armist Tehua Amoa , Fulgence Koffi Yao , Francine Ake Moussan Désirée , Kouabenan Abo , Mireille Alloue-Boraud Waze Aimée , Daouda Kone
Published: September 2024

The cashew tree (Anacardium occidentale L.) is of vital importance to the Ivorian economy. Côte d’Ivoire is first world producer. However, its cultivation faces several constraints linked to anthracnose. The aim of this study was to assess the efficacy of two formulated bacterial biocontrol agents against anthracnose of cashew. To this end, in vitro confrontation tests were carried out against Colletotrichum gloeosporioides with two previously formulated bacterial biopesticides. Biocontrol tests were then carried out against anthracnose in greenhouses and cashew plantations. The results showed that the two bacterial biocontrol agents tested controlled in vitro the proliferation of Colletotrichum gloeosporioides responsible for anthracnose and significantly reduced the disease severity index on cashew seedlings in the greenhouse. In vitro, inhibition rates ranging from 70.16±6.9 to 72.65±6.5% were observed on the mycelial growth of Colletotrichum gloeosporioides. In the greenhouse and in cashew plantations, a sharp reduction in the anthracnose severity index was observed. In the greenhouse, anthracnose reduction rates by the two bacterial biocontrol agents ranged from 62.80 ± 5.2% to 85.95 ± 2.8%. In cashew plantations, the reduction rates varied from 42.24 to 41.05%. In view of the above, these two bacterial biocontrol agents could be used for biological control of cashew anthracnose in Côte d'Ivoire.
Computational Screening of Phytochemicals from Trigonella foenum-graecum as Potential Inhibitor of Alpha-Amylase and Maltase-Glucoamylase in Treatment of Type 2 Diabetes
Authors: Akinsulure Simbo T. , Alao Oluwadamilola P. , Bodun Damilola S.
Published: September 2024

Introduction: Diabetes mellitus is a major illness suffered by several individuals, a metabolic dysfunction of glucose that leads to life-threatening complications. Type 2 diabetes is a combination of insulin action resistance, insufficient insulin production, and excessive glucagon secretion.
Aim: Numerous medications have been developed to manage diabetes mellitus by inhibiting various glucose metabolism enzymes and transporter proteins. However, the several adverse effects and high cost of treatment cannot be ignored. Thus, discovering and designing a small-molecule inhibitor with minimal side effects targeting vital proteins linked to glucose metabolism is essential.
Methodology: This study utilizes a computer-aided drug design approach to identify bioactive compounds from Trigonella foenum-graecum with inhibitory potential against alpha-amylase and maltase-glucoamylase, which are glucose-metabolizing proteins. The compounds retrieved from the PubChem database were screened against the protein retrieved from the Protein Data Base using molecular docking analysis, binding energy study, and ADME Toxicity Screening.
Result: Inositol, Isovitexin, Luteolin, Miglitol, Mimosine, Quercetin, Riboflavin, and Vitexin were identified to have high inhibitory potentials. These compounds showed impressive binding to the target proteins and admirable double-action inhibition of the proteins. The ADME Toxicity screening of the compounds also revealed that they are good drug candidates.
Conclusion: The lead compounds are potential inhibitors of Alpha-Amylase and Maltase-Glucoamylase. Further preclinical investigation is advised to validate this study.
Evaluation of Irrigation Efficiency in the Boghol Valley, Rural Commune of Dabaga, Aïr Massif, Niger
Authors: OUMAROU Maman Bachar IBRAHIMA , ADAMOU Mahaman Moustapha
Published: September 2024

The Aïr Massif is located in northern Niger. It is characterized by an arid climate that makes rain-fed agriculture impossible. To adapt, the population has developed irrigation from alluvial aquifers. The latter are dependent on rain and have a recurrent drying out. This results in the loss of crops or even abandonment of vegetable gardens leading to a subsequent decrease in production. In this context of aridity, the rational use of water is essential and necessarily involves knowledge of the water needs of crops and those delivered to these crops. The objective of this study is to assess the efficiency of irrigation water use in the Boghol Valley. The methodological approach is based on the calculation of water needs of crops using cropwat 8.0 software which required an inventory of soils, crops and areas they occupy according to the season. Then, the volume of water delivered at local scale was quantified using a volumetric meter. Finally, a comparison of the needs and quantities delivered at the valley level was made after extrapolation of data from the local scale. The results of the study show that irrigation is mainly carried out by gravity throughout the year. The quantities of water delivered are for all crops exceeding their needs. Overall irrigation efficiency of 71.07% was recorded. However, there are disparities with values of 80.75% and 49.70 % in the cold dry season and hot dry season respectively. This reflects considerable water losses in this arid environment. It is therefore necessary to improve efficiency by diagnosing irrigation practices.
Developing a Model for Open Channel Fluid Flow with a Segment Base having Lateral Inflow Channel
Authors: Nyaga Charles Mwaniki , Okongo Mark , Kirimi Jacob
Published: September 2024

An open channel fluid flow is characterized by presence of a free surface. The interface between two homogeneous fluids of different densities is regarded as free surface. It is the surface of the liquid that is in contact with air. Generally, this interface is subject to zero parallel shear stress. The survival of lives and livelihoods has greatly been hampered by occurrence of floods. When there is heavy downpour, accumulation of flooded water has led to bridges being washed away, increased pot holes on the roads and this has led to increased cases of accidents leading to loss of lives. This has posed a huge financial burden to the Government in terms of budgetary allocations to import human capital for maintenance and repair of worn out roads and bridges. This study has developed a model for fluid flow past an open channel with a trapezoidal cross-section with a segment base having lateral inflow channel that has optimal dimensions for maximum discharge. The fluid particles throughout the flow do not crisscross each other and hence the entire flow is assumed to be laminar. The developed model equations are non-dimensionalized, discretized and solved using finite-difference method and numerical values are simulated using Matlab Mathematical software. The findings are discussed, analyzed and presented graphically. It is reported that an increase in length of the lateral channel leads to decrease in flow velocity of the main channel. An angle of inclination of the lateral channel at a range of 300 to 450 exhibit higher values of flow velocity in the main channel compared to other angles. However, maximum velocity at the main channel is attained at an inclination angle of 300. At this angle, there is minimum shear stress hence less resistance to the flow profile. The results of this study is highly applicable in the design of drainage systems for road construction, sewer building, street drainage, airport construction and dams for electric power plants in Kenya and elsewhere.
Performance Optimization of a Terracotta Tube-Based Direct Evaporative Cooling System
Authors: Windnigda ZOUNGRANA , Makinta BOUKAR , Ousmane COULIBALY , Christian TUBREOUMYA Guy , Antoine BERE
Published: September 2024

This study presents the design and testing of a lab-scale Terracotta Flat Tubular direct evaporative cooler constructed from locally sourced materials. The key components of the system include a galvanized steel box, hollow baked clay tubes with a flat geometry, an axial fan, and a low-power submersible water pump. Experiments were conducted to evaluate the effects of varying intake air velocity, and water temperature. The experiment was carried out between 2:30 PM and 5:00 PM where air temperature and humidity in the test room stabilize. The results demonstrated temperature reductions ranging from 5.9°C to 15.7°C, outlet relative humidity levels between 52% and 95%, and cooling effectiveness values from 0.41 to 1.11. The optimal performance of the cooler was achieved at air velocities of up to 1 m/s and water temperatures around 18°C, at which the Feasibility Index is less than 11, which is in the range of the recommended value. The prototype achieved a cooling capacity of 62 W, with a coefficient of performance ranging from 3.3 to 5.6. Recommendations for future work include scaling up the system and enhancing its compactness to improve performance, making it suitable for enhancing indoor air quality and thermal comfort in rural households, schools, and offices with limited power access, as well as assisting small-scale farmers in reducing postharvest losses of horticultural products.
A β‐mannan utilization locus in Bacteroides ovatus involves a GH36 α‐galactosidase active on galactomannans
Authors: Reddy Sumitha K. , Bågenholm Viktoria , Pudlo Nicholas A. , Bouraoui Hanene , Koropatkin Nicole M. , Martens Eric C. , Stålbrand Henrik
Published: June 2016

The Bacova_02091 gene in the β‐mannan utilization locus of Bacteroides ovatus encodes a family GH36 α‐galactosidase (BoGal36A), transcriptionally upregulated during growth on galactomannan. Characterization of recombinant BoGal36A reveals unique properties compared to other GH36 α‐galactosidases, which preferentially hydrolyse terminal α‐galactose in raffinose family oligosaccharides. BoGal36A prefers hydrolysing internal galactose substitutions from intact and depolymerized galactomannan. BoGal36A efficiently releases (> 90%) galactose from guar and locust bean galactomannans, resulting in precipitation of the polysaccharides. As compared to other GH36 structures, the BoGal36A 3D model displays a loop deletion, resulting in a wider active site cleft which likely can accommodate a galactose‐substituted polymannose backbone.