bluuebunny/crossref_metadata_2025 huggingface dataset:
Wolfram syndrome 1 regulates sleep in dopamine receptor neurons by modulating calcium homeostasis
Authors: Hao Huanfeng , Song Li , Zhang Luoying
Published: July 2023

Sleep disruptions are quite common in psychological disorders, but the underlying mechanism remains obscure. Wolfram syndrome 1 (WS1) is an autosomal recessive disease mainly characterized by diabetes insipidus/mellitus, neurodegeneration and psychological disorders. It is caused by loss-of function mutations of the WOLFRAM SYNDROME 1 (WFS1) gene, which encodes an endoplasmic reticulum (ER)-resident transmembrane protein. Heterozygous mutation carriers do not develop WS1 but exhibit 26-fold higher risk of having psychological disorders. Since WS1 patients display sleep abnormalities, we aimed to explore the role of WFS1 in sleep regulation so as to help elucidate the cause of sleep disruptions in psychological disorders. We found in Drosophila that knocking down wfs1 in all neurons and wfs1 mutation lead to reduced sleep and dampened circadian rhythm. These phenotypes are mainly caused by lack of wfs1 in dopamine 2-like receptor (Dop2R) neurons which act to promote wake. Consistently, the influence of wfs1 on sleep is blocked or partially rescued by inhibiting or knocking down the rate-limiting enzyme of dopamine synthesis, suggesting that wfs1 modulates sleep via dopaminergic signaling. Knocking down wfs1 alters the excitability of Dop2R neurons, while genetic interactions reveal that lack of wfs1 reduces sleep via perturbation of ER-mediated calcium homeostasis. Taken together, we propose a role for wfs1 in modulating the activities of Dop2R neurons by impinging on intracellular calcium homeostasis, and this in turn influences sleep. These findings provide a potential mechanistic insight for pathogenesis of diseases associated with WFS1 mutations.
Thousands of Pristionchus pacificus orphan genes were integrated into developmental networks that respond to diverse environmental microbiota
Authors: Athanasouli Marina , Akduman Nermin , Röseler Waltraud , Theam Penghieng , Rödelsperger Christian
Published: July 2023

Adaptation of organisms to environmental change may be facilitated by the creation of new genes. New genes without homologs in other lineages are known as taxonomically-restricted orphan genes and may result from divergence or de novo formation. Previously, we have extensively characterized the evolution and origin of such orphan genes in the nematode model organism Pristionchus pacificus. Here, we employ large-scale transcriptomics to establish potential functional associations and to measure the degree of transcriptional plasticity among orphan genes. Specifically, we analyzed 24 RNA-seq samples from adult P. pacificus worms raised on 24 different monoxenic bacterial cultures. Based on coexpression analysis, we identified 28 large modules that harbor 3,727 diplogastrid-specific orphan genes and that respond dynamically to different bacteria. These coexpression modules have distinct regulatory architecture and also exhibit differential expression patterns across development suggesting a link between bacterial response networks and development. Phylostratigraphy revealed a considerably high number of family- and even species-specific orphan genes in certain coexpression modules. This suggests that new genes are not attached randomly to existing cellular networks and that integration can happen very fast. Integrative analysis of protein domains, gene expression and ortholog data facilitated the assignments of biological labels for 22 coexpression modules with one of the largest, fast-evolving module being associated with spermatogenesis. In summary, this work presents the first functional annotation for thousands of P. pacificus orphan genes and reveals insights into their integration into environmentally responsive gene networks.
Serum brain-derived neurotrophic factor (BDNF) and self-paced time-trial performance in older untrained men
Authors: Chia Eevon , Marino Frank E.
Published: July 2023

Purpose

This study examined the effect of 12 weeks of concurrent aerobic and resistance training on brain derived neurotrophic factor (BDNF) levels, neuromuscular performance and cerebral oxygenation on self-paced cycling exercise in previously untrained older men.

Methods

Eight untrained healthy males aged 53–64 years performed a familiarisation and a pre-training self-paced cycling time trial before 12 weeks of exercise training which combined aerobic and resistance exercise. The self-paced cycling time trial comprised a 30 s maximal effort sprint for every 4.5 min of lower intensity pace for a total of 25 min. Upon completion of 12 weeks of training, a comparison of the pre-training trial analysed for serum BDNF, neuromuscular performance, and cerebral oxygenation was undertaken.

Results

Serum BDNF decreased significantly from 10.02 ± 4.63 to 6.96 ± 3.56 ng/ml after 12 weeks of training. There was also attenuated physiological strain for a comparable self-paced cycling performance. Despite positive physiological responses during the time trial pacing strategy was not altered compared with pre training.

Conclusion

BDNF decreases following 12 weeks of concurrent training and might reflect neuroplasticity for this type of training stimulus. Exercise training in previously sedentary older men can result in a multitude of physical benefits, which may also confer a neuroprotective effect. However, specific training is required to improve pacing strategies in previously untrained older males.

Clinical trial registration

Australian New Zealand Clinical Trials Registry number ACTRN12622001477718.
Food frequency questionnaire for foods high in sodium: Validation with the triads method
Authors: Souza Diana S. , Santos Bianca I. , Costa Brenda M. , Santos Dalila M. , Aragão Laryssa G. S. , Pires Liliane V. , Vieira Diva A. S. , Freire Analícia R. S. , Barbosa Kiriaque B. F.
Published: July 2023

This study aimed to validate a food frequency questionnaire for foods high in sodium (FFQ-FHS) in a population aged ≥18 years and to test its reproducibility. This cross-sectional study included 50 individuals (≥18 years) of both sexes. In addition to the FFQ-FHS, four 24-h dietary recalls (24hRs) were conducted and a socioeconomic and lifestyle questionnaire was administered. Two 24-h urinary excretions were collected for sodium analysis, and anthropometry was performed. For validation, the triad method was applied using the validity coefficient (ρ). For reproducibility, the intraclass correlation coefficient (ICC), 95% confidence interval, kappa coefficient, and Bland–Altman plots were used to check for agreement. The Kolmogorov-Smirnov test was used to verify the data distribution. The validity coefficients for daily energy-adjusted sodium intake were high for the 24hR (ρRAI = 0.85) and weak for the FFQ-FHS (FFQAI = 0.26) and biomarker (ρBAI = 0.20). The ICC values were 0.68 for unadjusted sodium and 0.54 for energy-adjusted sodium intake. The weighed Kappa scores were 0.49 (p<0.01) and 0.260 (p = 0.02) for unadjusted and adjusted sodium intake, respectively. Although the FFQ-FHS is reproducible, it is not valid for the assessment of sodium intake and cannot be the sole instrument used for this purpose.
The synergistic effect of residues 32T and 550L in the PA protein of H5 subtype avian influenza virus contributes to viral pathogenicity in mice
Authors: Yang Hui , Dong Yurui , Bian Ying , Huo Chenzhi , Zhu Chuncheng , Qin Tao , Chen Sujuan , Peng Daxin , Liu Xiufan
Published: July 2023

The avian influenza virus (AIV) PA protein contributes to viral replication and pathogenicity; however, its interaction with innate immunity is not well understood. Here, we report that the H5 subtype AIV PA protein strongly suppresses host antiviral defense by interacting with and degrading a key protein in interferon (IFN) signaling, Janus kinase 1 (JAK1). Specifically, the AIV PA protein catalyzes the K48-linked polyubiquitination and degradation of JAK1 at lysine residue 249. Importantly, the AIV PA protein harboring 32T/550L degrades both avian and mammalian JAK1, while the AIV PA protein with residues 32M/550I degrades avian JAK1 only. Furthermore, the residues 32T/550L in PA protein confer optimum polymerase activity and AIV growth in mammalian cells. Notably, the replication and virulence of the AIV PA T32M/L550I mutant are attenuated in infected mice. Collectively, these data reveal an interference role for H5 subtype AIV PA protein in host innate immunity, which can be targeted for the development of specific and effective anti-influenza therapeutics.
Percepción de aprendizaje de estudiantes durante la pandemia y factores contextuales y pedagógicos asociados
Authors: Matamala Carolina , Claro Magdalena , Hinostroza Juan Enrique
Published: July 2023

El objetivo de la investigación fue conocer la percepción de aprendizaje de estudiantes de primaria y secundaria durante la enseñanza remota y los factores contextuales y pedagógicos que explican dicha percepción. Se utilizó una metodología cuantitativa basada en la aplicación de una encuesta, validada a través de panel de expertos, a una muestra no probabilística de 8.538 estudiantes (4.598 de primaria y 3.940 de secundaria) de la Región de La Araucanía de Chile, quienes fueron seleccionados por su nivel educativo y por pertenecer a establecimientos públicos que aceptaron ser parte del estudio. Los resultados permiten determinar que, a pesar del cambio de modalidad de enseñanza, un poco más de un tercio de las y los estudiantes consideran haber aprendido mucho durante el primer año de pandemia, siendo estudiantes de enseñanza básica, del área urbana y con acceso a tecnología quienes presentaron una mayor percepción de aprendizaje. Los principales factores pedagógicos que permiten explicar dicha percepción de aprendizaje son la comunicación con docentes, asistir a clases por videoconferencia, responder guías o tareas y aprender la materia por cuenta propia utilizando diversos recursos. Estos resultados permiten concluir que aspectos centrales en la percepción de aprendizaje durante la enseñanza remota en pandemia fueron una interacción frecuente con los docentes y acceder a recursos, tanto para el estudio acompañado como autónomo. Por otra parte, confirman la desventaja de los estudiantes sin conectividad a Internet, particularmente aquellos de zonas rurales.
Hubungan Bayi Berat Lahir Rendah dengan Kejadian Hiperbilirubinemia di Rumah Sakit Umum Daerah Wangaya Kota Denpasar
Authors: Armatheina Putu Fristy , Suryawan I Wayan Bikin , Indrawan I Gde Doddy Kurnia
Published: July 2023

Latar belakang. Hiperbilirubinemia merupakan salah satu keadaan klinis yang paling sering ditemukan pada bayi baru lahir. Angka kejadian bayi hiperbilirubin berbeda di satu tempat ke tempat lainnya. Hal ini disebabkan oleh perbedaan faktor penyebab seperti berat bayi lahir. Berdasarkan data dari The Fifty Sixth Session of Regional Committee, World Health Organization kematian bayi terjadi pada usia neonatus dengan penyebab tersering hiperbilirubinemia. Pravelensi dan tingkat keparahan hiperbilirubinemia ditemukan lebih tinggi pada bayi berat lahir rendah (BBLR). Tujuan. Penelitian ini bertujuan untuk mengetahui hubungan bayi berat lahir rendah dengan kejadian hiperbilirubinemia.Metode. Penelitian ini merupakan penelitian observasional analitik dengan pendekatan potong lintang yang dilaksanakan pada bulan Agustus – September 2022 di Rumah Sakit Umum Daerah Wangaya. Subjek penelitian adalah bayi usia 0-28 hari yang dirawat serta berat lahir bayi dan hasil pemeriksaan kadar bilirubin tercatat dalam rekam medis periode juni 2021 sampai dengan juni 2022 yang memenuhi kriteria inklusi dan eksklusi. Pengambilan sampel penelitian dilakukan secara consecutive sampling. Dilakukan analisis bivariat menggunakan uji Chi-square. Data dianalisis dengan SPSS versi 20 untuk Windows. Hasil. Pada penelitian ini didapatkan 92 sampel. Sampel bayi berat lahir rendah didapatkan sebesar 58,7% dan 89,1 sampel di antaranya mengalami hiperbilirubinemia. Hasil uji hipotesis dengan uji Chi-square diperoleh nilai p=0,033. Kesimpulan. Terdapat hubungan yang bermakna antara bayi berat lahir rendah dengan hiperbilirubinemia pada nenonatus di Rumah Sakit Umum Daerah Wangaya.
Exploring the Impact of Diaspora and Skilled Migration on Developing Countries
Authors: Eslit Edgar  R.
Published: July 2023

This qualitative study delves into the complexities of diaspora, migration, and brain drain within the Philippines, surpassing the confines of the traditional economic lens to explore their social, cultural, and psychological dimensions. Drawing on a robust theoretical framework, the research unveils key insights by conducting in-depth analysis of empirical data, shedding light on diaspora dynamics, migration patterns, and the factors influencing migration decisions. Additionally, it examines the wide-ranging impacts of diaspora and migration on sending and receiving societies, elucidating their social, economic, and cultural implications. Informed by these findings, the study offers valuable policy recommendations to stakeholders and decision-makers, emphasizing the importance of leveraging the potential of diaspora, promoting social integration, and addressing knowledge gaps. By contributing to the existing body of knowledge and informing evidence-based strategies, this comprehensive research aims to facilitate sustainable development and enhance social well-being through a profound understanding of diaspora, migration, and brain drain.
Sprint design – aplicação em portal web de serviços públicos de São Paulo - SP, Brasil
Authors: Pelinson Taís , Campese Carina
Published: July 2023

O sprint design é um método aplicado em cinco dias utilizado pelo google venture para gerar novas ideias conectadas à gestão estratégica, inovação, ciência comportamental e design para softwares, marketing, serviços e outras áreas, além de garantir uma busca de soluções mais eficiente, rápida e focada nos desafios. A abrangência de assuntos nos quais o sprint design pode ser aplicado permitiu a escolha de um tema a ser tratado, que é o objetivo desse trabalho: a execução do método em um projeto de arquitetura da informação de um portal web de serviços públicos do município de São Paulo. Neste trabalho éapresentado um ciclo de sprint design aplicado junto a uma equipe de transformação digital de serviços públicos, cidadãos e servidores públicos da cidade de São Paulo para encontrar soluções ao desafio proposto de dificuldade em entender as informações do site em questão.  Pelo resultado do método executado no contexto da gestão pública com algumas adaptações, foi possível perceber a eficácia e garantia de entrega de uma solução co-construída entre governo e cidadãos de forma rápida, eficiente, testada e focada nos munícipes. Além disso, tornou-se perceptível que a inclusão de servidores públicos e de cidadãos no processo do sprint design contribuiu para expandir uma cultura de fomento à inovação e construção de políticas públicas da agenda de governo digital junto à sociedade.
Assistive technology for autism spectrum disorder children that experiences stress and anxiety
Authors: Pergantis Pantelis , Drigas Athanasios
Published: July 2023

With the development of current technology and influences that have been made by the Industry 4.0 utilizing ICTs, IoT, smart systems and products and many others, Assistive Technology (AT) is an important and integral part of the daily life of many people who experience disabilities. Autism Spectrum Disorder (ASD) is a special category of disorder that can greatly benefit from its use. The purpose of this research is to collect data of Assistive Technology aimed at the detection, prevention and improvement of anxiety and stress (a characteristic of which has been proven to exist and is expressed in various ways in people with ASD). In the introduction, basic definitions regarding the neurobiology of stress and ASD are analyzed. In the main part AT, stress and anxiety correlations are made with ASD and AT devices are described and documented regarding their use for anxiety and stress in children and adolescents with ASD. The Assistive equipment and devices are divided into 2 main categories, 1) Low-tech and 2) Mid-High tech. The results of the research reveal a significant research gap in the use of AT to combat stress and anxiety and the difficulty of many promising options (especially in the domain of Mid-High tech) to be an easy and economical solution in integrating them into the daily life of people with ASD.
Analysis of Data on Accidental Falls from the Hospital Incident Reporting in a General Hospital
Authors: Jang Yu-ri , Park Jeong Yun
Published: July 2023

Purpose: The purpose of this study was to analyze data on fall incidents based on a general hospital’s incident reporting system.Methods: This study conducted secondary data analysis to gather statistics on fall reports, general characteristics of patients, results of falls, and improvement strategies for fall prevention using the 2017-2019 fall incidents from the incident report system.Results: There were 693 cases reported over three years. Among the fall incidents, three hundred twenty (46.2%) were adverse events, three hundred seventy-three (53.8%) were near misses, and none were related to sentinel events. Five hundred ninety-five (85.9%) were male, with an average age of 74.08±8.99. The falling incidents happened mostly in patients' rooms (410, 59.1%). At the time of the fall, the patients were conscious and alert (607, 87.6%). As a result of the fall, three hundred sixty (51.9%) caused no harm, permanent damage, side effects, or death.Conclusion: The study findings suggest that the fall characteristics of older patients should be considered to establish a fall-prevention strategy tailored to the institution.
Analysis of Communication Content on Bedside Rounds in a Hospital - Implications for Patient Centered Communication
Authors: Jang Yeon-Hoon , You Myoung-Soon , Park Gi-Beom , Suh Bong-Won , Song Chang-Eun
Published: July 2023

Purpose: Few studies on bedside rounds have focused on the principles of patient-centered communication (PCC). This study pursued three objectives. First, we investigated the verbal contents of bedside rounds from the PCC perspective. Next, we analyzed inpatient surveys concerning patients’ experience of and perspective regarding bedside rounds. Finally, we identified which factors affect patient satisfaction levels.Methods: To evaluate doctor-patient communication, the contents of bedside rounds from 151 patients (88 in medical wards and 63 in surgical wards) were analyzed using the Roter Interaction Analysis System. An inpatient survey was also conducted to obtain further information about patient experience.Results: The average duration of bedside rounds was 71.3 seconds. The distribution of conversations between doctors and patients was significantly different, with doctors accounting for 62% and patients for 38% of the total (p<.001). Both doctors (44.7%) and patients (40.5%) considered provision of biomedical information as the most important aspect of communication. On the other hand, the proportion of psychological-social communication was relatively low in both groups, at 2.3% and 4.2%, respectively. In the inpatient survey, 40.8% of respondents reported being uninformed about the ward round in advance, while 44.7% stated that the rounds did not take place at the pre-informed time. While 66.7% of participants felt that the interaction during rounds was sufficient, those who felt that they had insufficient round time were the least satisfied. There was a positive correlation between sufficiency of the bedside round duration and overall satisfaction with bedside round (p<.01).Conclusion: The findings of this study indicate that neither the verbal contents of the bedside rounds nor the overall patient satisfaction adequately meet the conditions for patient centeredness.
Trends in Second Victim Support Programs for Healthcare Providers: A Literature Review
Authors: Choi Eun Young , Pyo Jeehee , Jang Seung Kyoung , Lee Won , Ock Minsu , Lee Haeyoung
Published: July 2023

Purpose: This study aimed to review second victim support programs to identify effective evidence-based strategies for supporting healthcare providers involved in patient safety incidents.Methods: A comprehensive review search was conducted, including a search of databases, gray literature, and a hand-search of related fields, with “second victim” as the main search term.Results: We reviewed nine second victim support programs, focusing on their development process, operating form, and performance. These were (a) Peer Support Services, (b) forYOU team, (c) YOU Matter, (d) Resilience in Stressful Events, (e) Clinician Peer Support Program, (f) SWADDLE, (g) Surgery Second Victim Peer Support Program, (h) Caring for the Caregiver, and (i) Code Lavender.Conclusion: Second victim support programs help solve the emotional problems of medical staff caused by patient safety incidents. Therefore, it is necessary to develop a second victim support program suitable for the medical environment in Korea.
TEKNIK DAN FUNGSI PENERJEMAHAN KATA UMPATAN PADA NOVEL RIḤLAH ILĀ ALLĀH
Authors: Baking Aad Nur Sayyidus Syuhuur , Sajarwa Sajarwa
Published: July 2023

This study aims to find out the translation techniques of swear words in the novel Riḥlah ilā Allāh by Najib Kaelani and the function of those swear words. The data in this study are in the form of swear words and their translations which are sourced from the novel Riḥlah ilā Allāh and its translation "Meniti Jalan Allah". The used theory for this research is the translation techniques from Molina & Albir’s perspectives, and Swear words functions by Trudgill & Andersson. This research is descriptive and qualitative with the data collection method using the reading and note-taking method. Furthermore, the data analysis technique starts by grouping the data, looking for the techniques used in translating swear words, then determining the function of the swear words that have been collected. The results showed that the swear words in the novel Riḥlah ilā Allāh by Najib Kailani were translated using eight techniques, and have three functions, namely expletive, abusive, and auxiliary.
Caffeine intake almost always affects physical performance and cognitive processes responsible for awareness
Authors: De Giorgio Roberto
Published: July 2023

Sports foods and supplements can play a significant role in the sports nutrition plans of high-level athletes. It has been found that taking specific dietary supplements can have ergogenic and performance-enhancing effects. Over the past two decades, there have been no major changes in the recommendations for caffeine supplementation. However, scientific knowledge has been significant in recent times, such that the state of the art needs to be updated. This study aims to confirm that caffeine (1,3,7-trimethylxanthine), a substance found in beverages such as coffee, tea and energy drinks, can be both an ergogenic support for individuals engaged in physical activity and an effective cognitive support. In this context, this review outlines the current framework of knowledge. The relationship between the uses and effects of caffeine in power and endurance sports has been demonstrated. In order to achieve and maintain the high levels of performance required in sporting events, planning proper sports diet supplementation can only strengthen and revitalize athletes after strenuous training. Furthermore, the effects of caffeine intake on the state of alertness have been evaluated in the military as well. Significant physical performance, such as marching over rough terrain, sometimes with very heavy loads, may be required during military training and tactical operations. In addition, operational situations with reduced or sleep deprivation may occur.Thus, several studies argue that genetic background, diet, gender identity and hormonal status have a bearing on the absorption, metabolism and physiological and functional effects of caffeine. Regarding the key points - individualized dosages and timing of caffeine intake - it would be desirable to go further with the studies to optimize the effects of caffeine.
Compensation mechanisms for post-traumatic thoracolumbar kyphosis
Authors: Borzykh K. O. , Rerikh V. V.
Published: July 2023

Objective. To identify the mechanism of deformity compensation in patients with post-traumatic kyphosis of the thoracolumbar junction, based on the analysis of X-ray results of surgical treatment.

Material and Methods. The study included data obtained from medical records of 69 patients (47 women, 22 men) operated on for painful post-traumatic kyphosis at the levels of T12, L1 and L2 vertebra. Patients underwent staged surgical interventions in a single surgical session. Demographic data and X-ray results of surgical treatment were evaluated.

Results. As a result of surgical interventions, post-traumatic kyphosis (LK) was corrected to an average of 1.9°. After correction of kyphosis, statistically significant changes in the parameters of sagittal spinal curvatures were revealed: an increase in thoracic kyphosis (TK), a decrease in lumbar lordosis (LL), including due to lower lumbar lordosis (LowLL). At the same time, the parameters of the spinopelvic balance (PT, SS) did not change. Statistically significant correlations (p < 0.001) were detected between the magnitude of local kyphosis correction (LK preOP-LKpostOP), which amounted to 33.63° ± 8.77°, and parameters of lumbar lordosis ΔLL, thoracic kyphosis ΔTK and ΔPI-LL. Parameters of global sagittal balance and pelvic balance did not show correlations with the magnitude of kyphosis correction. The X-ray study of patients in Group I (without signs of initial sagittal imbalance) and Group II (with signs of sagittal imbalance) revealed a statistically significant difference in global balance (GT) and spinopelvic balance (PT, SS, LowLL), both before and after correction intervention in the thoracolumbar junction area, despite comparable indicators of sagittal spinal curvatures and the magnitude of post-traumatic kyphosis,.

Conclusion. The main compensation mechanism includes changes in the spinal departments adjacent to kyphosis: a decrease in thoracic kyphosis and an increase in lumbar lordosis, rather than changes in the global or spinopelvic balance.
The effectiveness of growth-friendly systems in the treatment of early onset scoliosis: a systematic review
Authors: Molotkov Yu. V. , Ryabykh S. O. , Filatov E. Yu. , Sergeenko O. M. , Khuzhanazarov I. E. , Eshkulov D. I.
Published: July 2023

Objective. To perform a systematic analysis of the literature evaluating the effectiveness of growth-friendly systems in the treatment of early onset scoliosis.

Material and Methods. A subject search was conducted in the Google Scholar database for the terms “growing rods”, “early onset scoliosis”, “treatment”, “surgery” and “growth-friendly” using AND or OR logical operators with a search depth of 10 years. At the first stage, 824 abstracts of publications were selected. The second stage of search was carried out in accordance with the PICOS criteria, 38 abstracts of original studies, case series and reviews of surgical techniques for spinal deformity correction with preservation of growth potential were selected. The evaluation criteria were divided into four groups: general data, correction of the frontal and sagittal components of the deformity, complications and unplanned scenarios.

Results. In the analyzed studies, gender equality of distribution was observed, and the average age at the time of the primary operation was 6.6 years for patients with traditional growing rods (TGR) and Schilla/Luque trolley and 4.9 years for patients with Vertical Expandable Prosthetic Titanium Rib (VEPTR). From the point of view of the magnitude of spinal deformity correction, the VEPTR systems demonstrated the minimum result (18 % correction), and the TGR and Schilla results were comparable (42.1 and 53.1 %, respectively), as well as the indicators of the dynamics of body lengthening.

Conclusion. The use of VEPTR systems is associated with a high risk of complications and a somewhat lower efficiency of spinal deformity correction, however, VEPTR is indispensable in the treatment of thoracic insufficiency syndrome, as well as severe deformities of  the axial skeleton in young children using non-vertebral fixation points. Growth modulation systems (Schilla and Luque trolley) showed deformity correction results similar to those of TGR.
Assessment of the technical-economic performance and optimization of a parabolic trough solar power plant under Algerian climatic conditions
Authors: Bouchareb Khaled , Ihaddadene Nabila , Belkhiri Khellaf , Ikhlef Khaoula , Boudilmi Aissa
Published: July 2023

In this study, the design, analysis and optimization of the performance of a concentrated solar power plant that is based on the parabolic trough technology with a capacity of 100 MW equipped with a thermal energy storage system were conducted, in two representative sites in Algeria (Tamanrasset and M’Sila). The System Advisor Model software is used to evaluate the technical and economic performances of the two proposed power plants, in addition to carrying out the process of optimizing the initial design of the two power plants by finding the optimal values of the solar multiple and full load hours of the thermal energy storage system, with the aim of increasing the annual energy production and reducing the levelized cost of electricity. The results of the performance analysis conducted on the optimized design showed that the optimum values of the solar multiple and full load hours of the thermal energy storage system for the proposed power plant at the Tamanrasset site were found to be 2.4 and 7 h, respectively, with an annual electricity production of 514.6 GWh, and a minimum value of the levelized cost of electricity of 6.3¢/kWh. While the optimum performance of the proposed plant at the M'Sila site can be achieved by selecting a solar multiple of 3 and 7 h for thermal energy storage system, with a high annual energy production of 451.84 GWh and a low value of the levelized cost of electricity of 7.8¢/kWh. The results demonstrate that CSP plants using parabolic trough technology can increase energy security in the country, while reducing environmental concerns associated with the use of fossil materials.
„Nasze ścieżki staną się drogami”: Ekogroznawcze refleksje wokół Death Stranding Hideo Kojimy
Authors: Zaborowski Karol
Published: July 2023

The article discusses the issue of environmental game studies, which the author defines as an analysis of the involvement of video games in environmental discourses. In order to formulate a definition of an eco-game, the author uses Lawrence Buell’s environmental text theory and Alenda Y. Chang’s postulates from the manifesto of environmentally conscious game design, as well as references to works in the field of post-humanistic philosophy. He also invokes concepts derived from gaming studies to describe the ecological contexts of the medium of video games. In the second part of the work, environmental game theory is used to analyse an example of an eco-game. The author chose the AAA production Death Stranding created by the Japanese designer Hideo Kojima. Looking at its unconventional depiction of a post-apocalyptic wasteland, the biopolitics regulating the life of the protagonist and the gameplay based on unhurried exploration of space, the author outlines potential further directions for the development of research in the field of environmental game studies.
Gracz-turysta. Przewodniki po grach i kształtowanie doświadczenia użytkownika
Authors: Chojnacki Marcin M.
Published: July 2023

The article addresses the issue of the gamer-tourist. The author discusses it from the perspective of a specific reception attitude, consisting in transferring behaviours and expectations typical of virtual tourism to gameplay. The article also takes a closer look at the issue of guides targeted at gamers, specific paratexts that can shape the user experience by formatting the vision of gameplay.
Postklasyczna groza. Przeobrażenia fuzji gatunkowej survival horroru
Authors: Staszenko-Chojnacka Dominika
Published: July 2023

This article provides an introduction to the study of the transformation of the survival horror genre. The author discusses the genre determinants of horror games from the historical perspective, draw- ing particular attention to the moment when the classic survival horror formula emerged. She also describes the changes over the years that led both to the need to update the genre framework and to the division into classic and post-classic horror games. She also analyses the mechanics typical of contemporary productions using horror elements.
Motyw podróży w czasie w grach cyfrowych – podstawowe typy mechanik
Authors: Czyżak Krzysztof
Published: July 2023

This article is an attempt to describe the ways in which the theme of time travel functions in video games. The text presents the two most common types of incorporating time travel into game mechanics. In the first type, an avatar has the ability to manipulate gameworld time. In the second case, time travel is simulated by a transfer of the avatar into a different game area. The article constitutes a step towards more advanced research on time travel in video games.
A new assessment method for right ventricular diastolic function using right heart catheterization by pressure‐volume loop
Authors: Isotani Yoshitaka , Amiya Eisuke , Hatano Masaru , Kiriyama Hiroyuki , Uehara Masae , Ishida Junichi , Tsuji Masaki , Bujo Chie , Narita Koichi , Ishii Satoshi , Kakuda Nobutaka , Minatsuki Shun , Yagi Hiroki , Saito Akihito , Numata Genri , Yamada Takanobu , Kurihara Takahiro , Suzuki Tatsuya , Komuro Issei
Published: July 2023

Diastolic stiffness coefficient (β) and end‐diastolic elastance (Eed) are ventricular‐specific diastolic parameters. However, the diastolic function of right ventricle had not been investigated sufficiently due to the lack of established evaluation method. We evaluated the validity of these parameters calculated using only data of right heart catheterization (RHC) and assessed it in patients with restrictive cardiomyopathy (RCM) and cardiac amyloidosis. We retrospectively analyzed 46 patients with heart failure who underwent RHC within 10 days of cardiac magnetic resonance (CMR). Right ventricular end‐diastolic volume and end‐systolic volume were calculated using only RHC data, which were found to be finely correlated with those obtained from CMR. β and Eed calculated by this method were also significantly correlated with those derived from conventional method using CMR. By this method, β and Eed were significantly higher in RCM with amyloidosis group than dilated cardiomyopathy group. In addition, the β and Eed calculated by our method were finely correlated with E/A ratio on echocardiography. We established an easy method to estimate β and Eed of right ventricle from only RHC. The method finely demonstrated right ventricular diastolic dysfunction in patients with RCM and amyloidosis.
ANÁLISIS DE LOS FACTORES QUE INFLUYEN EN EL MODELO ESTRATÉGICO PUBLICITARIO Y SU IMPACTO EN EL COMPORTAMIENTO DEL CONSUMIDOR: CASO DE ESTUDIO MAGUSEVA
Authors: Arroba Edison , Toapanta Cunalata Diego Gustavo , Toscano Ramos Orlando Rubén
Published: July 2023

MAGUSEVA es una empresa que se dedica a la producción y elaboración de asientos para autobuses, así como otros productos fabricados con materiales de plástico duro para su uso en hogares, empresas o negocios. La compañía ha destacado por la calidad de sus productos y la satisfacción de sus clientes, lo que ha permitido su crecimiento y posicionamiento en el mercado. Sin embargo, en un entorno competitivo en el que las empresas deben destacar y diferenciarse, se ha visto en la necesidad de desarrollar estrategias publicitarias y promocionales efectivas para aumentar su producción y ventas. En respuesta a esta necesidad, se llevó a cabo una investigación con el objetivo de fortalecer el diseño de las campañas publicitarias para afianzar la relación con los clientes actuales y atraer a nuevos. Para ello, se utilizó una metodología cuantitativa con un paradigma crítico propositivo, y la técnica utilizada fue la encuesta, con el cuestionario como instrumento para validar los datos obtenidos. Los resultados demuestran que el 77% de los encuestados prefieren descuentos en sus compras, mientras que el 23% desea productos de regalo. Se concluye que la empresa, tiene una gran cuota de mercado de más del 70%, lo que le permite mantener su estabilidad como empresa y expandirse abriendo nuevas sucursales para satisfacer las necesidades de los consumidores.
Sex Differences in Transcatheter Structural Heart Disease Interventions: How Much Do We Know?
Authors: Ya’Qoub Lina , Arnautovic Jelena , Faza Nadeen N. , Elgendy Islam Y.
Published: July 2023

The number of structural heart disease interventions has greatly increased in the past decade. Moreover, interest in the sex-specific outcomes of various cardiovascular conditions and procedures has increased. In this review, we discuss the sex differences in the clinical profiles and outcomes of patients undergoing the most commonly performed structural procedures: transcatheter aortic valve replacement, transcatheter edge to edge repair of the mitral and tricuspid valve, transcatheter pulmonary valve replacement, patent foramen ovale closure and left atrial appendage occlusion. We shed light on potential reasons for these differences and emphasize the importance of increasing the representation of women in randomized clinical trials, to understand these differences and support the application of these cutting-edge technologies.
Mechanical Behavior of Hybrid Laminated Nano Composite Containing Equal Numbers of Glass and Carbon Fiber Plies
Authors: Ava Mohammed  , Gailah Ismail Hassan  , Younis Khalid Khdir
Published: July 2023

Hybrid fiber reinforced polymer with nanofiller composite was introduced into a lot of industries due to its extreme mechanical properties in comparison with non-hybrid material. In this investigation, cross and quasi-fiber laminated epoxy composites with and without nano Al2O3 were fabricated using Vacuum Assisted Resine Infusion Method and Ultrasonic Dual Mixing Method. In general, the results of mechanical properties indicated that the addition of 2% nano Al2O3 enhances the tensile and flexural properties. Cross number 2 with nano Al2O3 laminate had the maximum tensile strength 628 MPa and maximum tensile strain of 1.74%, while cross number 1 with nano Al2O3 laminate had the maximum tensile modulus of 37.756 GPa in the cross group. In the quasi group, quasi number 2 with nano Al2O3 had the maximum tensile strength, maximum tensile strain, and maximum tensile modulus, equal to 294 MPa, 1.98%, and 16.409 GPa, respectively. Regarding the flexural properties, cross number 1 with nano Al2O3 laminate had a maximum flexural strength of 708.2 MPa and maximum flexural strain of 2.027%, while cross number 2 with nano Al2O3 laminate had a maximum flexural modulus of 38.73 GPa in the cross group. On the other hand, quasi number 1 with nano Al2O3 laminate had the maximum flexural strength, maximum flexural strain, and maximum flexural modulus equal to 596 MPa, 2.424%, and 29.2 GPa, respectively in the quasi group. The internal structures of the failure laminated composites through scanning electronic microscopy confirm that the adhesion between fibers and matrix is good.
Socialization: Innovations of Recent Decades
Authors:   Моscow Pedagogical State University, Мudrik Аnatolii Viktorovich
Published: July 2023

The relevance of the stated research is determined by the insufficient study of what is new in the process of socialization of the younger generations and how positively and negatively this new phenomenon affects the practice of education. The purpose of the article is to offer a preliminary typology of new socialization phenomena. The leading methodological approach in the study was phenomenological, which used methods of monographic study of organizations and entities, questionnaires of respondents and interviews with informants, contemplative and participatory participant observation, study of scientific texts, press materials and Internet resources. Results of the study. The study confirmed that a completely new phenomenon of the socialization was the Internet, which gave rise to cybersocialization, which affects the factors of socialization, spheres of life of children, adolescents, young men and women, types of education (family, social, religious, dissociational, correctional). Socialization of the younger generations in recent decades is taking place in the reconstruction of the mentality of society, which affects the ratio of traditional and innovative in the process of socialization. Such new phenomena as the inclusion of adolescents in making money, consumerism, vagrancy are characterized. Particular attention is paid to the influence on the socialization of adolescents of the “shuttle” parents and their participation in the “garage economy”. The social differentiation of family socialization and its manifestation in various forms is outlined. Relatively socially controlled socialization received new organizational forms in all types of education, which are “inventoried” in the text. Conclusion. The materials of the article can be used by teachers of psychological and pedagogical disciplines, students and graduate students in socio-humanitarian training areas.
Determining Factors of Asset Misappropriation Tendency by Employees in Perspective of Fraud Hexagon Theory
Authors: Wahyulistyo Farlina , Cahyonowati Nur -
Published: July 2023

AbstractPurpose: This study aims to provide empirical evidence and analyze factors that contribute to asset misappropriation by employees through the fraud hexagon theory perspective. The theory consists of six components that trigger fraud, such as stimulus (incentives), opportunities, rationalization, capabilities, ego, and collusion. In this study, the stimulus factor is divided into financial and non-financial (job pressure).Method: The study obtains data by distributing questionnaires to 218 participants employees from 5 departments of XTZ Hospital in Semarang. Only those who work in structural and functional positions are the participants, considering they are responsible for the hospital asset management. To collect data, this study implements a proportional stratified random sampling method, and test the hypothesis by using the 7.0 version of WarpPLS analysis tool.Findings: The results indicate that financial pressure, opportunity, capability, ego, and collusion influence asset misappropriation. Meanwhile, non-financial pressure (job pressure) and rationalization do not contribute to misappropriation.Novelty: This research implies an overview of why the management has to carefully review the factors that lead to asset misappropriation in the workplace. Besides, these can be used for formulating guidelines to prevent misappropriation. Keywords: Financial pressure, fraud hexagon theory, asset misappropriation
Custom triflange acetabular components for large acetabular defect reconstruction in revision total hip arthroplasty: a systematic review and meta-analysis on 1218 patients
Authors: Broekhuis Demien , Tordoir Rutger , Vallinga Zoe , Schoones Jan , Pijls Bart , Nelissen Rob
Published: July 2023

Purpose

This is a systematic review and meta(regression) analysis to assess the performance of custom triflange acetabular components (CTAC) in total hip arthroplasty (THA) revision surgery. Implant-related complications, failure rate, functional outcomes and implant and surgical technique-related predictors for outcome were assessed.

Methods

This systematic review was performed according to PRISMA guidelines and registered with PROSPERO (2020 CRD42020209700). PubMed, Embase, Web of Science, COCHRANE Library and Emcare were searched. Studies on Paprosky type 3A and 3B or AAOS type 3 and 4 acetabular defects with a minimum follow-up of 12 months and cohorts > 10 patients were included.

Results

Thirty-three studies were eligible for inclusion (n = 1235 hips, 1218 patients). The methodological quality of the studies was moderate (AQUILA: 7.4/11 points). Considerable heterogeneity was observed in terms of complications, re-operations and implant failure reporting. The total incidence of implant-related complications was 24%. The incidence of re-operation for any reason was 15%, and the implant failure rate was 12% at a mean of 46.9 months and the post-operative Harris Hip Score improved by a mean of 40 points. Several predictors for outcome were found, such as implant generation, follow-up length and study start date.

Conclusions

The use of CTAC in revision THA has satisfactory complication and implant failure rates. The CTAC technique improves post-operative clinical outcomes and the meta-regression analysis showed that there is a clear association between improvements in the CTAC performance and the evolvement of this technique over time.
The effect and mechanism of motor control exercise on low back pain: a narrative review
Authors: Xu Hao-Ran , Zhang Yong-Hui , Zheng Yi-Li
Published: July 2023

Low back pain (LBP) is a common symptom that can occur in all ages. It is the first common cause of disability globally and is associated with over 60 million disability-adjusted life-years in a single year.

Motor control exercise (MCE) has obtained increasing attention in treating LBP. However, the findings from distinct meta-analyses differed and some even reached controversial conclusions. More importantly, how MCE improves LBP-related symptoms remains unclear.

The primary aim of this study is to describe the possible improvement mechanisms of MCE on LBP from brain, biochemistry, inflammatory, and neuromuscular aspects. The secondary aim is to further conclude its effectiveness and clinical application. Further understanding of mechanisms and effectiveness could be instructive for future LBP treatments and provide more information for clinicians when making prescriptions.

MCE is effective in alleviating pain and disability among patients with acute and chronic LBP. Notably, the evidence for acute LBP is relatively low-quality and limited.

MCE might be more effective for patients with specific LBP characteristics, especially those with pre-diagnosis of impaired transversus abdominis recruitment, intermediate pain intensity, and longer MCE training duration.

MCE could remap brain representation and reverse negative brain alternation, induce exercise-induced hypoalgesia, mediate anti-inflammatory response, retain normal activation, and improve morphological deficits.
Polynomial composites and certain types of fields extensions
Authors: Matysiak Ł.
Published: July 2023

In this paper, we consider polynomial composites with the coefficients from $K\subset L$. We already know many properties, but we do not know the answer to the question of whether there is a relationship between composites and field extensions. We present the characterization of some known field extensions in terms of polynomial composites. This paper contains the open problem of characterization of ideals in polynomial composites with respect to various field extensions. We also present the full possible characterization of certain field extensions. Moreover, in this paper we show that any finite group is a Galois group of some field extensions and present the inverse Galois problem solved.
On wavelet type Bernstein operators
Authors: Karsli H.
Published: July 2023

This paper deals with construction and studying wavelet type Bernstein operators by using the compactly supported Daubechies wavelets of the given function $f$. The basis used in this construction is the wavelet expansion of the function $f$ instead of its rational sampling values $f\big( \frac{k}{n}\big)$. After that, we investigate some properties of these operators in some function spaces.
The animal economy of Ancient Dilmun in the light of faunal remains from excavations at Saar and Qala'At Al-Bahrain
Authors: Uerpmann M. , Uerpmann H. P.
Published: July 2023

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