bluuebunny/crossref_metadata_2025 huggingface dataset:
Targeted therapy monitoring of BRAF-V600-mutant Erdheim-Chester disease by fast quantitative whole-body bone CZT-tomoscintigraphies
Authors: Melki Saifeddine , Moulinet Thomas , Verger Antoine , Marie Pierre-Yves , Imbert Laetitia , Bahloul Achraf
Published: January 2023

Erdheim-Chester disease (ECD) is a rare histiocytosis due to proto-oncogene mutations, primarily affecting the long bones and possibly being treated by novel targeted therapies. 18F-FDG PET is a reference technique for ECD assessment. However, we present a case where easier and more objective monitoring of the ECD-related bone metabolism abnormalities under treatment was obtained with the standardized uptake value-based information provided by fast whole-body [Tc-99 m]-HDP bone tomoscintigraphies (QWBT) recorded with a high-sensitivity CZT-camera/computed tomography (CT) hybrid system.
Reflex seizures induced by micturition: a case report
Authors: Zhang Zhiyun , Li Qiwei , Jiang Tiejia , Fang Jiajia
Published: January 2023

Background

Reflex seizures (RS) induced by micturition are extremely rare, and the clinical and electroencephalogram features of RS are not widely known among clinicians. In particular, the origin of the epileptic area is still unclear.

Case presentation

An 8-year-old girl who had generalized tonic-clonic seizures was diagnosed with RS induced by micturition based on the clinical manifestation and EEG recordings. We also reviewed the clinical and EEG characteristics of RS induced by micturition in literature by searching the databases of PubMed and MEDLINE using keywords “micturition reflex seizure”, “reflex seizure induced by micturition”, and “micturition induced seizure” by January 2022. We speculate that the mechanism of micturition-induced RS may involve excessive neuronal excitation in regions that participate in micturition.

Conclusions

The RS in this patient was considered to be induced by micturition. Awareness should be raised to this rare form of RS among practitioners.
Granulation tissue after otologic surgeries: a cross-sectional report on the incidence and management
Authors: Rajati Mohsen , Nazarpour Parisa , Afzalzadeh Mohamad Reza
Published: January 2023

Background

Granulation tissue (GT) formation is a complication of otologic surgeries. We aimed to assess the rate of GT formation following these procedures and their outcome.

Methods

This cross-sectional study was performed from 2015 to 2019. Patients who underwent tympanomastoidectomy (either CWD or ICW) and stapedotomy were included. Demographic and other related data were gathered. Four weeks after surgery, patients were assessed for any sign of granulation tissue formation. If present, they were managed topically and were followed every 2 months until complete resolution.

Results

Of 1045 included cases, 200 underwent Canal Wall Down (CWD) mastoidectomy, 568 underwent Intact Canal Wall (ICW) mastoidectomy, and 277 experienced stapedotomy. Four weeks after surgery, 180 participants were diagnosed with GT (17.22%). The incidence rate of GT formation following tympanomastoidectomy and stapedotomy is 23.44% and 0%, respectively. This measure is 43% and 16.5% for CWD, and ICW approaches. Following treatment for 2 months, we found 164 (91.1%) participants with complete resolution at the second visit. Of the remaining 16 cases, 10 and 6 were cured at the third and fourth visits. Males developed GT significantly more (p < 0.001).

Conclusion

Those with CWD mastoidectomy are more likely to develop GT than ICW and stapedotomy surgeries. It has a favorable response to conservative topical management.
International Consensus Guideline on Small for Gestational Age: Etiology and Management From Infancy to Early Adulthood
Authors: Hokken-Koelega Anita C S , van der Steen Manouk , Boguszewski Margaret C S , Cianfarani Stefano , Dahlgren Jovanna , Horikawa Reiko , Mericq Veronica , Rapaport Robert , Alherbish Abdullah , Braslavsky Debora , Charmandari Evangelia , Chernausek Steven D , Cutfield Wayne S , Dauber Andrew , Deeb Asma , Goedegebuure Wesley J , Hofman Paul L , Isganatis Elvira , Jorge Alexander A , Kanaka-Gantenbein Christina , Kashimada Kenichi , Khadilkar Vaman , Luo Xiao-Ping , Mathai Sarah , Nakano Yuya , Yau Mabel
Published: January 2023

This International Consensus Guideline was developed by experts in the field of small for gestational age (SGA) of 10 pediatric endocrine societies worldwide. A consensus meeting was held and 1300 articles formed the basis for discussions. All experts voted about the strengths of the recommendations. The guideline gives new and clinically relevant insights into the etiology of short stature after SGA birth, including novel knowledge about (epi)genetic causes. Further, it presents long-term consequences of SGA birth and also reviews new treatment options, including treatment with gonadotropin-releasing hormone agonist (GnRHa) in addition to growth hormone (GH) treatment, as well as the metabolic and cardiovascular health of young adults born SGA after cessation of childhood GH treatment in comparison with appropriate control groups.

To diagnose SGA, accurate anthropometry and use of national growth charts are recommended. Follow-up in early life is warranted and neurodevelopment evaluation in those at risk. Excessive postnatal weight gain should be avoided, as this is associated with an unfavorable cardiometabolic health profile in adulthood. Children born SGA with persistent short stature < −2.5 SDS at age 2 years or < −2 SDS at 3 to 4 years of age, should be referred for diagnostic workup. In case of dysmorphic features, major malformations, microcephaly, developmental delay, intellectual disability, and/or signs of skeletal dysplasia, genetic testing should be considered. Treatment with 0.033 to 0.067 mg GH/kg/day is recommended in case of persistent short stature at age of 3 to 4 years. Adding GnRHa treatment could be considered when short adult height is expected at pubertal onset. All young adults born SGA require counseling to adopt a healthy lifestyle.
Neurosurgical Outcomes for Pediatric Central Nervous System Tumors in the United States
Authors: Chalif Eric J. , Morshed Ramin A. , Oh Taemin , Dalle Ore Cecilia , Aghi Manish K. , Gupta Nalin
Published: January 2023

BACKGROUND:

Limited data exist on pediatric central nervous system (CNS) tumors, and the results from the National Cancer Database, the largest multicenter national cancer registry, have not previously been comprehensively reported.

OBJECTIVE:

To capture pediatric neurosurgical outcomes and investigate possible disparities of care.

METHODS:

The National Cancer Database was queried for pediatric patients who were diagnosed with CNS tumors from 2004 to 2018. Primary outcomes included 30/90 days postoperative mortality (30M/90M), readmission within 30 days of discharge (30R), and length of inpatient stay (LOS).

RESULTS:

Twenty four thousand nine hundred thirty cases met the inclusion criteria, of which were 4753 (19.1%) juvenile pilocytic astrocytomas, 3262 (13.1%) medulloblastomas, 2200 (8.8%) neuronal/mixed neuronal-glial tumors, and 2135 (8.6%) ependymal tumors. Patients aged 0 to 4 years had significantly poorer outcomes than patients in older age groups (90M: 3.5% vs 0.7%-0.9%; 30R: 6.5% vs 3.6%-4.8%; LOS: 12.0 days vs 6.0-8.9 days). Tumor size was a strong predictor of poor outcomes with each additional cm in diameter conferring a 26%, 7%, and 23% increased risk of 90M, 30R, and prolonged LOS, respectively. Data over the study period demonstrated year over year improvements of 4%, 3%, and 2%, respectively, for 90M, 30R, and prolonged LOS. Facilities with a high volume of pediatric tumor cases had improved 90M (1.1% vs 1.5%, P = .041) and LOS (7.6 vs 8.6 days, P < .001). Patients with private health insurance had better outcomes than patients with government insurance.

CONCLUSION:

There is substantial variability in surgical morbidity and mortality of pediatric CNS tumors. Additional investigation is warranted to reduce outcome differences that may be based on socioeconomic factors.
Association of Preoperative Vascular Wall Imaging Patterns and Surgical Outcomes in Patients With Unruptured Intracranial Saccular Aneurysms
Authors: Hu Liuxun , Quan Kai , Shi Yuan , Liu Peixi , Song Jianping , Tian Yanlong , An Qingzhu , Liu Yingjun , Li Sichen , Yu Guo , Fan Zhiyuan , Luo Jianfeng , Gu Yuxiang , Xu Bin , Zhu Wei , Mao Ying
Published: January 2023

BACKGROUND:

MR vascular wall imaging (VWI) may have prognostic value in patients with unruptured intracranial aneurysms (UIAs).

OBJECTIVE:

To evaluate the value of VWI as a predictor of surgical outcome in patients with UIAs.

METHODS:

This prospective cohort study evaluated surgical outcomes in consecutive patients with UIAs who underwent surgical clipping at a single center. All participants underwent high-resolution VWI and were followed for at least 6 months. The primary clinical outcome was modified Rankin scale (mRS) score 6 months after surgery.

RESULTS:

The number of patients in the no wall enhancement, uniform wall enhancement (UWE), and focal wall enhancement (FWE) groups was 37, 145, and 154, respectively. Incidence of postoperative complications was 15.5% in the FWE group, 12.4% in the UWE group, and 5.4% in the no wall enhancement group. The proportion of patients with mRS score >2 at the 6-month follow-up was significantly higher in the FWE group than in the UWE group (14.3% vs 6.9%; P = .0389). In the multivariate analysis, FWE (odds ratio, 2.573; 95% CI 1.001-6.612) and positive proximal artery remodeling (odds ratio, 10.56; 95% CI 2.237-49.83) were independent predictors of mRS score >2 at the 6-month follow-up.

CONCLUSION:

Preoperative VWI can improve the surgeon's understanding of aneurysm pathological structure. Type of aneurysmal wall enhancement on VWI is associated with clinical outcome and incidence of salvage anastomosis and surgical complications.
Comparing Impact and Concussion Risk in Leatherhead and Modern Football and Hockey Helmets
Authors: Huang Jaxon J. , Goya Kellie N. , Yamamoto Brennan E. , Yamamoto Loren G.
Published: January 2023

BACKGROUND:

Improvements in the modern helmet have demonstrated beneficial effects in reducing concussion risk in football players. However, previous studies yield conflicting results regarding the protective quality of leatherhead football helmets. There is limited research comparing the modern football helmet and the modern hockey helmet, with one previous study demonstrating the football helmet as providing a lower risk of concussion.

OBJECTIVE:

To compare the head acceleration produced in a leatherhead football helmet vs a modern football helmet vs a modified modern football helmet with softer padding vs a modern hockey helmet in helmet-to-helmet strikes.

METHODS:

Accelerometers were placed on the frontal, apex, and parietal regions of a Century Body Opponent Bag manikin. Each type of helmet was placed on the manikin and struck by a swinging modern football helmet. The G-force acceleration was determined in three-dimensional axes of 100 total helmet-to-helmet impacts.

RESULTS:

The leatherhead football helmet was the least protective in reducing G-forces. The modified modern football helmet did not provide a significant difference compared with the modern football helmet. Significantly greater G-forces were produced in a collision between 2 modern football helmets in comparison with 2 modern hockey helmets.

CONCLUSION:

The leatherhead football helmet was the least protective, and the hockey helmet was the most protective, with the football helmet being intermediate. This study provides additional insight into the inconclusive evidence regarding the safety of leatherhead football helmets and into the design of football and hockey helmets in the future.
The Evolution of Endoscopic Endonasal Approach for Olfactory Groove Meningiomas
Authors: Champagne Pierre-Olivier , Zenonos Georgios A. , Wang Eric W. , Snyderman Carl H. , Gardner Paul A.
Published: January 2023

BACKGROUND:

There is controversy over the choice of optimal approach for olfactory groove meningiomas (OGM). The endoscopic endonasal approach (EEA) is one of the most recently described corridors, which provides direct access to the tumor base.

OBJECTIVE:

To detail the evolution of the endoscopic endonasal technique over the past 2 decades and demonstrate the impact of this evolution on patient outcomes.

METHODS:

This is a retrospective study based on a prospectively maintained database of consecutive cases of OGM operated on at our institution via EEA. For analysis, the whole cohort has been divided into 3 equal “eras” according to the time period during which the surgery happened, creating early, middle, and contemporary groups.

RESULTS:

Seventy-five patients were included, 25 in each group. The rate of postoperative cerebrospinal fluid leak significantly decreased over time (28%, 32%, and 8% in the early, middle, and contemporary groups, respectively, P = .020). The rate of postoperative encephalomalacia was significantly lower in more recent groups (24%, 16%, and 0% in the early, middle, and contemporary groups, respectively, P = .029), as was the time to resolution of postoperative brain edema (103.9 months, 87.3 months, and 16.8 months in the early, middle, and contemporary groups, respectively, P = .020).

CONCLUSION:

The endoscopic endonasal approach for OGM significantly evolved over time, achieving lower cerebrospinal fluid leak rates while providing a high rate of Simpson grade 1 resection. Technical improvements minimized the frontal lobe impact. Current data support EEA as a safe and effective corridor to treat OGM.
Applications of Carbon Fiber Instrumentation in Spinal Oncology: Recent Innovations in Spinal Instrumentation and 2-Dimensional Illustrative Operative Video
Authors: Oh Justin , Visco Zachary R. , Ojukwu Disep I. , Galgano Michael A.
Published: January 2023

BACKGROUND:

The management of spinal oncology necessitates a multimodal approach, with surgical intervention, radiation-based therapy, and postoperative advanced imaging. These systems must work well together to provide optimal patient outcomes. Traditional metallic spinal implants produce image artifacts and lead to radiation dose attenuation, which inhibit both disease monitoring and disease treatment, respectively.

OBJECTIVE:

To demonstrate the feasibility of an improved biomaterial implant that provides structural stability, while also allowing for disease monitoring and treatment in spinal oncology patients.

METHODS:

From February 2021 to September 2021, 3 patients with spinal oncologic deformity requiring resection and posterior spinal stabilization underwent fixation with polyether ether ketone-carbon fiber implants at a single academic institution.

RESULTS:

Patient ages ranged from 23 to 74 years (mean: 44.7 years). All patients underwent posterior spinal fixation using standard approaches. They each received polyether ether ketone-carbon fiber pedicle screw and rod implants, placed in standard fashion. There were no dural tears, postoperative wound infections, or other complications related to their treatment. Postoperative surveillance revealed gross total resection of the targeted tumor on postoperative radiographic imaging.

CONCLUSION:

Polyether ether ketone-carbon fiber implants are a safe and effective option for the treatment of thoracolumbar posterior spinal pathology. The utilization of this novel type of instrumentation in posterior spinal approaches may provide benefit to patients with spinal tumors over existing forms of posterior spinal instrumentation.
Peak Cardiac Output Determined Using Inert Gas Rebreathing: A Comparison of Two Exercise Protocols
Authors: BOSTAD WILLIAM , MCCARTHY DEVIN G. , RICHARDS DOUGLAS L. , HELAL LUCAS , GIBALA MARTIN J.
Published: January 2023

Peak cardiac output (Q˙
peak) can be measured noninvasively using inert gas rebreathing (IGR). There is no consensus on the optimal protocol to measure Q˙
peak using IGR, which requires a rebreathing period of ~10 s as close to “maximal” exercise as possible.

Purpose

This study aimed to compare Q˙
peak elicited by a constant load protocol (Q˙
CL) and an incremental step protocol (Q˙
step).

Methods

A noninferiority randomized crossover trial was used to compare Q˙
peak between protocols using a noninferiority margin of 0.5 L·min−1. Participants (n = 34 (19 female, 15 male); 25 ± 5 yr) performed two baseline V̇O2peak tests to determine peak heart rate (HRpeak) and peak work rate (W
peak). Participants then performed the Q˙
CL and Q˙
step protocols each on two separate occasions with the order of the four visits randomized. Q˙
peak was measured using IGR (Innocor; COSMED, Rome, Italy). The Q˙
CL protocol involved a V̇O2peak test followed 10 min later by cycling at 90% W
peak, with IGR initiated after 2 min. Q˙
step involved an incremental step test with IGR initiated when the participant’s HR reached 5 bpm below their HRpeak. The first Q˙
CL and Q˙
step tests were compared for noninferiority, and the second series of tests was used to measure repeatability (typical error (TE)).

Results

The Q˙
CL protocol was noninferior to Q˙
step (Q˙
CL = 17.1 ± 3.2, Q˙
step = 16.8 ± 3.1 L·min−1; 95% confidence intervals, −0.16 to 0.72 L·min−1). The baseline V̇O2peak (3.13 ± 0.83 L·min−1) was achieved during Q˙
CL (3.12 ± 0.72, P = 0.87) and Q˙
step (3.12 ± 0.80, P = 0.82). The TE values for Q˙
peak were 6.6% and 8.3% for Q˙
CL and Q˙
step, respectively.

Conclusions

The Q˙
CL protocol was noninferior to Q˙
step and may be more convenient because of the reduced time commitment to perform the measurement.
In vivo and in vitro generation of tumor antigen-specific T cells using human CD34+ hematopoietic stem cells or engineered mature T cells
Authors: Στεφανίδης Ευάγγελος-Νεκτάριος
Published: January 2023

Η τεράστια ώθηση των τελευταίων δεκαετιών στην έρευνα για τον καρκίνο έχει μεταμορφώσει ριζικά την κλινική πραγματικότητα. Ωστόσο, πολλοί ασθενείς εξακολουθούν να μην επωφελούνται από τα τρέχοντα κλινικά πρωτόκολλα. Η ανοσοθεραπεία κατά του καρκίνου που στοχεύει στην ενεργή συμμετοχή του ανοσοποιητικού συστήματος του ασθενούς στην καταπολέμηση της ασθένειας έχει αναδειχθεί ως ισχυρό συμπλήρωμα στις τυπικές θεραπείες περίθαλψης. Η αυτόλογη μεταφορά Τ λεμφοκυττάρων (ACT) βρίσκεται στην καρδιά των κυτταρικών ανοσοθεραπειών και περιλαμβάνει την απομόνωση, πολλαπλασιασμό και αναζωογόνηση των Τ κυττάρων του ασθενούς, πριν την επανέγχυσή τους. Παρ’ όλα αυτά, τα επανεισαγόμενα Τ λεμφοκύτταρα χαρακτηρίζονται από περιορισμένης διάρκειας παρουσία και δραστηριότητα in vivo, ενώ το ιδιαίτερα ανοσοκατασταλτικό, προσαρμοστικό καρκινικό μικροπεριβάλλον, ειδικά των στερεών όγκων, αποτελεί εμπόδιο στην επιτυχία της ACT. Τα μακροφάγα, που αποτελούν την πλειοψηφία των ανοσοκυττάρων σε πολλούς όγκους και αποτελούν σημαντικό συστατικό του καρκινικού μικροπεριβάλλοντος, μπορούν να καταστείλουν ενεργά τη συσσώρευση και τη δραστηριότητα των Τ κυττάρων που αναγνωρίζουν ειδικά τον όγκο. Αντίθετα, δενδριτικά κύτταρα μπορούν να υποστηρίξουν αντικαρκινικές ανοσολογικές αποκρίσεις και να διεγείρουν αποτελεσματικά τη δραστηριότητα των Τ κυττάρων. Με στόχο τον επαναπρογραμματισμό του καρκινικού μικροπεριβάλλοντος και την ενίσχυση των θεραπειών ACT, περιγράφουμε τη δημιουργία ειδικών για τον όγκο «θωρακισμένων» Τ κυττάρων που έχουν περαιτέρω τροποποιηθεί ώστε να εκκρίνουν παράγοντες με ανοσορρυθμιστική δράση. Δείχνουμε ότι τα «θωρακισμένα» Τ κύτταρα παράγοντας διαλυτά μόρια που μπλοκάρουν το ανοσοκατασταλτικό μονοπάτι CD47/SiRPα ενισχύουν τη φαγοκυτταρική ικανότητα μακροφάγων που προέρχονται από ποντικό και άνθρωπο έναντι ανθρώπινων καρκινικών κυττάρων in vitro και βελτιώνουν τον έλεγχο του καρκινικού όγκου in vivo. Επιπλέον, για να επιτύχουμε μακροπρόθεσμη αντικαρκινική προστασία και να παρατείνουμε την παρουσία και δράση των κυτταρικών θεραπειών in vivo, αναφέρουμε τη δημιουργία Τ κυττάρων ειδικών για τον όγκο από γενετικά τροποποιημένα αιμοποιητικά βλαστοκύτταρα και διερευνούμε τον πιθανή χρήση των παραγόμενων προγονικών Τ κυττάρων στην κυτταρική θεραπεία με Τ λεμφοκύτταρα. Εν κατακλείδι, η έρευνά μας χρησιμοποιεί ως εφαλτήριο και ενισχύει καθιερωμένες μεθοδολογίες που βασίζονται στη μεταφορά κυττάρων, και εισάγει νέα κυτταρικά προϊόντα με βελτιωμένες ανοσορρυθμιστικές και αντικαρκινικές ιδιότητες, τα οποία μπορούν να αναδιαμορφώσουν το κατασταλτικό καρκινικό μικροπεριβάλλον και να πυροδοτήσουν αποτελεσματικές ανοσολογικές αντιδράσεις κατά του καρκίνου.
Entre el «cara a cara» y la multiplicidad de candidatos: el debate electoral televisado en Europa (2019 – 2022).
Authors: Morales Rafael , García Gordillo María del Mar
Published: January 2023

El debate televisivo es el momento más importante de una campaña electoral, un acto de comunicación política que genera gran cantidad de información y permite observar las cualidades de los líderes políticos. El actual concepto de debate mediático nace en Estados Unidos con el enfrentamiento por televisión entre Nixon y Kennedy en 1960, marcando un antes y un después en la comunicación política y en la historia de estos eventos mediáticos. Los debates electorales en Europa comenzaron paralelamente a los casos estadounidenses. Suecia fue la pionera en 1958, seguida de otros países como Alemania en 1969, Francia en 1974 o Italia en 1983; el primer debate electoral español aparece en 1993 entre Felipe González y José María Aznar. Reino Unido incorporó el debate televisado en 2010, convirtiéndose en uno de los países con menos tradición en este ámbito. Para conocer las principales características del debate electoral europeo, el presente trabajo de investigación analiza un total de 119 debates celebrados entre enero de 2019 y junio de 2022, todos ellos se emitieron en 18 países miembros de la Unión Europea, incluido Reino Unido. Tras la aplicación del análisis de contenido, los datos recopilados demuestran cómo los debates en Europa con dos candidatos son levemente superiores sobre aquellos donde existen más participantes políticos. Este estudio observa que el debate europeo todavía se encuentra entre el modelo «cara a cara» y un formato basado en la presencia de un número mayor de protagonistas.
European Capital of Culture 2028: For Which Identities and Values? French Bids for the Title in 2028
Authors: Thuriot Fabrice
Published: January 2023

The general objectives of the European Capitals of Culture are to safeguard and promote the diversity of cultures in Europe and the common features they share, while strengthening the sense of belonging to a common cultural space. The growing appeal of the title of European Capital of Culture, especially after the success of Lille (2004) and Marseille (2013), both in France, has led to numerous bids in the country, despite the high cost of preparation and implementation. Amiens, Bastia, Bourges, Clermont-Ferrand, Lens-Lievin, Nice, Reims, Roubaix, Rouen and Saint-Denis have already announced their candidacy to the title of European Capital of Culture in 2028, often in connection with their region. The article analyses the cultural and development projects of these cities and territories according to the criteria of European values and identities.
Dynamic Thiol-Disulfide Homeostasis in Children with Newly Diagnosed Iron Deficiency Anemia
Authors: KURUCU Burçak , FETTAH Ali , YEŞİL Şule , FIRAT OĞUZ Esra , EREL Özcan , ŞAHİN Gürses
Published: January 2023

Objective: Iron is an element, which is found in the structure of antioxidant enzymes and has an important role in the inactivation of reactive oxygen species. Disruption of oxidant-antioxidant balance may be playing a role in the pathogenesis of iron deficiency anemia (IDA). Dynamic thiol-disulfide homeostasis (DTDH) and serum ischemia-modified albumin (IMA) levels are important indicators of pro-oxidant/antioxidant status. In this study, we aimed to evaluate DTDH parameters and serum IMA levels in children with newly diagnosed IDA, who did not receive iron therapy.
Material and Methods: Fifty patients diagnosed with IDA and 33 healthy age- and sex-matched control patients were included in the study. DTDH parameters and IMA levels of the patients and control groups were measured. The same parameters were also compared in patients with Hb<7 g/dl (profound IDA) (n:14/50, 28%) and Hb≥7 g/dl (mild-moderate IDA) (n: 36/50, 72%) in the IDA group. The relationship between DTDH parameters in these groups were investigated.
Results: Native thiol, total thiol, native thiol/total thiol levels, constituting antioxidant capacity indicators, were found to be significantly lower in IDA patients; while oxidant disulfide, disulfide/native thiol, disulfide/total thiol, and IMA levels were found to be statistically higher compared to those in the control group (p<0.050). When DTDH parameters and IMA levels were examined; there was a positive correlation between antioxidant parameters and a negative correlation between oxidative parameters with hemoglobin and ferritin levels (p<0.050). Also, oxidative parameters were found to be much higher in profound IDA group than in the group with Hb>7 g/dl (p<0.050).
Conclusion: In this study, increase in serum disulfide and IMA levels with the decrease in serum native thiol and total thiol levels indicated oxidative stress in IDA patients before treatment, compared to the control group. Evaluation of these indicators in children is important in predicting the toxicity due to IDA.
O ambiente digital e a expografia: análise de conceitos para a exposição de acervos na internet
Authors: Lopes Renata Perim Albuquerque
Published: January 2023

Este artigo propõe uma reflexão sobre o crescente processo de digitalização de acervos das instituições culturais. A presença de museus, assim como suas exposições e conteúdo na internet, abre caminhos para pensar as diferentes formas de interação com as artes visuais no espaço físico e no meio digital. A partir da análise de uma obra do acervo digitalizado do Museu Histórico Nacional, propomos explicitar práticas e princípios do meio digital. Essas análises visam contribuir para o entendimento de que as representações digitais de obras de arte se adaptam ao ambiente on-line a partir de recursos específicos do meio sem necessidade de mimetização do recinto expositivo.
Achieving cost- effective digital change in practice
Authors: Elliott Jonathan
Published: January 2023

Jonathan Elliott calls for the NHS to embrace proven, UK developed digital solutions that build on existing NHS processes and systems that transform patient and clinician experience at a fraction of the cost and with minimal disruption
Wireless signals detect emotions
Authors: BRADSHAW MELISSA
Published: January 2023

UK study has potential use in health and wellbeing
Nissan Leaf completes 230-mile autonomous UK road journey
Authors: EXCELL JON
Published: January 2023

Complex real-world trial aims to make driverless cars more “human-like”
Project to Give SMEs ‘Plug-and-Play’ Predictive Maintenance
Authors: Ford Jason
Published: January 2023

Innovate UK-supported project aims for affordability
Stepping Aboard a Captured German U-boat
Authors: Excell Jon
Published: January 2023

The Engineer didn’t hold back on its praise for a German U-boat at the end of the Second World War
IT’s the End of the World as We Know It
Authors: Powell Gareth L.
Published: January 2023

When dystopian nightmares become a reality it will be engineers who pick up the pieces writes resident science fiction author Gareth L Powell
Luxury Amplified
Authors: Poultney Leon
Published: January 2023

Despite flirting with the idea, Rolls-Royce has yet to jump on the electrification bandwagon and produce its first EV, but CEO Torsten Müller-Ötvös admits that it is unavoidable if the company is to continue its success in the future
Next Generation
Authors: Grant Alex
Published: January 2023

BMW's second-generation hydrogen fuel cell powertrain is the result of shared platforms, common parts and cross-industry partnerships, but the company isn't underestimating the challenges ahead
Taking Charge
Authors: Gooding Richard
Published: January 2023

Higher charging power reduces electric vehicle battery top-up times but creates other more complicated issues for onboard charging technology. However, charger design is changing to deal with, and future-proof against, these increasingly complex demands
Opportunity Knocks
Authors: Evans Rachel
Published: January 2023

The 2015 takeover of Italian design house Pininfarina by Indian OEM Mahindra saw the company presented with an opportunity to reinvent itself. Enter Automobili Pininfarina, a newly formed luxury electric sports car maker
Keeping Track
Authors: Pickering Chris
Published: January 2023

The old adage of ‘win on Sunday, sell on Monday’ may no longer apply to most motorsport series, but Porsche’s hybrid and electric road car programs are genuinely benefiting from innovations developed on the track
The Factor
Authors: Gooding Richard
Published: January 2023

Formula E and Extreme E have proved electric racing is here to stay, and in 2022, the premier class of the FIA World Rallycross Championship slides into a zero-emission motorsport embrace. EHVTI looks under the skin of its all-electric RX1e and RX2-e racers
Racing Line
Authors: Gooding Richard
Published: January 2023

Motorsport has an enduring history of influencing the cars we drive, but how similar is the electrified technology which underpins the latest generation of electric and hybrid racers, and how will it impact future road car developments
Reality Bytes
Authors: Grant Alex
Published: January 2023

Byton will begin customer deliveries of its first production car in 2020; a highly-connected luxury electric SUV for the world's most demanding markets, born out of a fast-paced global development program
Where Data is King
Authors: Sampson Ben
Published: January 2023

Competing pressures and the need to innovate are just some of the factors shaping the instrumentation on Boeing's flight test programs
G500 is Go
Authors: Eden Paul E
Published: January 2023

Having found additional range in its G500, Gulfstream extended the type's flight test program into 2018. With FAA certification is go awarded, the airframer is working toward certifying the closely related G600 this year
Beyond the Pulse
Authors: Coppinger Rob
Published: January 2023

Electromagnetic testing is adapting to the potential threat of directed energy weapons, which pose a far greater challenge than the electromagnetic pulse from a nuclear blast
Hypervelocity Impact
Authors: Williams Andrew
Published: January 2023

High-speed imaging technology and techniques are being pushed to their limits to capture the effects of hypervelocity impacts
The Countdown to Net Zero
Authors: Holland Nik
Published: January 2023

For the industry to reach net zero within the 30 year target, it must be taking action today
Rebulding Industry
Authors: Bahr Nicholas
Published: January 2023

Companies must act now to mitigate against the economic effects of coronavirus
Muscling In
Authors: Fletcher Mark
Published: January 2023

Musculoskeletal conditions are becoming increasingly common in the workplace, causing absence and a loss of productivity. How can the physical world of manufacturing mitigate against this?
Pivoting for Success
Authors: Godsell Janet
Published: January 2023

The COVID-19 pandemic could be the perfect opportunity for UK manufacturing to radically change the way it operates
Storage Solutions
Authors: Rason Chris
Published: January 2023

As the UK heads towards a more renewable future, businesses are going to have to become more reliant on battery storage infrastructure
Waste Not, Want Not
Authors: Beck Chris
Published: January 2023

With Glasgow hosting the UN climate change summit in November, Scottish companies are taking the lead on the circular economy
Work Woes
Authors: Boyd JO
Published: January 2023

In these troubled times, mental health and wellbeing has never been more important
Finding Wisdom in Data
Authors:   Inawisdom
Published: January 2023

Award-winning data analytics and AI specialists, Inawisdom, are experts in driving the most value for your business from the data you are already producing on your shopfloor
A Family Affair
Authors: Beck Chris
Published: January 2023

Twenty years ago, the Paxman family was rocked by tragedy. From that, however, has grown an award-winning manufacturing firm that is changing lives across the world
Blinded by the Light
Authors: Beck Chris
Published: January 2023

Manufacturers can easily fall into the trap of assuming a sea of green lights on the shopfloor means everything is OK. However, harnessing data means even a green light can be improved upon
Making the Investment
Authors: O’flaherty Colin
Published: January 2023

With manufacturing SMEs predicting a period of growth in the coming years, they should be looking to ‘supercharge’ their business now
A Greener Future
Authors: DUNKERLEY BILL
Published: January 2023

Six months on from the enactment of the Environment Act 2021, what does the future hold for sustainability in UK manufacturing ?
A Sound Investment
Authors: RAWLINGS NATHAN
Published: January 2023

Why Additive Manufacturing should become a key part of every manufacturer’s plans for future investment
The Misunderstood Generation
Authors: Woakes David
Published: January 2023

With millennials set to make up the majority of those in employment by 2020, do workplaces need to do more to accommodate them?
Everyone Welcome
Authors: Beck Chris
Published: January 2023

Imagine a production line of industry-ready, multi-skilled engineering graduates, desperate for the chance to work for you. Sounds too good to be true? Well, think again…
Keeping the Momentum
Authors: Beck Chris
Published: January 2023

The push for Net Zero operations has been disrupted by the pandemic. However, even if investment is frozen, there are still things manufacturers can do to make sustainability a key part of their recovery – including taking a look at the behaviour behind Net Zero
Springing to Success
Authors: Beck Chris
Published: January 2023

Keighley manufacturer, Airedale Springs, is taking the opportunity to ensure the company is more robust against future disruption
Automation Anxiety
Authors: Tilley Keith
Published: January 2023

As COVID-19 changes the way we work, automation is set to become increasingly important – so should we be worried about the impact it will have on our lives?
3D Supply Chains
Authors: Langfeld Andreas
Published: January 2023

While the COVID-19 pandemic has shone a spotlight on 3D printing, many forward-thinking companies across the globe had already embedded the technology within their business models to great success
One Size Doesn’t Fit All
Authors: Edwards Donna
Published: January 2023

How Made Smarter’s pilot is giving manufacturing SMEs in the North West the confidence to adopt digitalisation
Interview
Authors: Norman Helen
Published: January 2023

Jo Wetz, CEO of Element Materials Technology, talks key investments, challenges and future trends, as the company further expands its presence into the simulation and modeling market
Getting Connected
Authors: Norman Helen
Published: January 2023

Nicola Tonello, global laboratory methods competence leader at Electrolux, looks at the latest electronic system testing processes being adopted and how connected devices have revolutionized test methodologies
Ttention to Detail
Authors: Harris Cliff
Published: January 2023

A new leak detection method, which can identify lithium-ion cell leaks thousands of times smaller than conventional methods, promises new breakthroughs in quality assurance for battery production
Performance Matters
Authors: Norman Helen
Published: January 2023

SGS reveals more details about its new Performance Mark and Total Solution Services offerings as it seeks to assist retailers, manufacturers and brands in elevating device usability and quality
Built for Speed
Authors: Geerts Justin
Published: January 2023

Environmental and highly accelerated life testing create an accelerated pathway to improved product quality and reliability
Space Crafted
Authors: Willis Paul
Published: January 2023

Many key technologies in consumer electronics owe their origins to NASA research. CET&D discovers what the space agency can teach us about the development of new products.
Hard Facts
Authors: Rogers Toby
Published: January 2023

Rigid plastics are widely used in the manufacturing of components for consumer electronics. This how-to guide reveals the equipment, techniques and standards for accurately testing them.
Super Model
Authors: Bruss Michael
Published: January 2023

Creating an artificial head for acoustic testing requires an in-depth understanding of how humans speak and hear. HEAD acoustics explains the technology underpinning their HMS II.3 test devices.
Speaker Protocol
Authors: Hillerin Marie Georgescu de
Published: January 2023

DXOMARK does not take audio lightly: the French quality evaluation expert built its own anechoic chamber, commissioned professional musicians, and even bought an apartment to use exclusively for its audio tests. But what exactly goes on behind the soundproof doors?
Testing New Tech to Produce Unbreakable Screens
Authors: Norman Helen
Published: January 2023

The mechanical properties of the new composite glass were measured using a nanoindentation test, which essentially sees a very sharp tip press onto the glass to measure its rigidity and hardness
Study of types of the Arthrostenus Schoenherr in C. J. Schoenherr collection, with a new synonymy (Coleoptera: Curculionidae)
Authors: GÜLTEKİN NESLİHAN
Published: January 2023

Types of the three species of Arthrostenus Schoenherr, 1826 described by C. H. Boheman, housed at the C. J. Schoenherr collection in the Swedish Museum of Natural History, Stockholm are examined. The lectotype is designated for Arthrostenus fullo Boheman, 1836. The holotypes of Arthrostenus spadiceus Boheman, 1836 and Arthrostenus cinereus Boheman, 1836 are conspecific, which resulted in a new synonymy as follows: Arthrostenus spadiceus Boheman, 1836 = Arthrostenus cinereus Boheman, 1836; syn. nov. Digital photographs for the three types are presented.
A New Scheme for Parallel Transmission of Power and Full-Duplex Mode Information Sharing with LCC Topology Based on IPT System
Authors: Manikandan T. , Nayak Panugothu Srinivasan Rao , Simon Sishaj P. , Sundareswaran Kinattingal
Published: January 2023

In this study, a full-duplex data communication module is designed and developed for sharing information in a contactless power transfer system. It is realized through LC tank circuits with an inductive power transfer (IPT) system. On both the transmitter and receiver sides, one LCC compensation topology is used. Since Phase Shift Keying (PSK) is less susceptible to error and power-efficient digital modulation techniques, this paper proposes to implement PSK digital modulation technique to data signal modulation for full-duplex communication in a wireless EV charger. The proposed scheme ensures stability, transfers load status, charging level, and emergency messages between the source and load sides of the system, and vice versa. The results are compared with the Amplitude Shift Keying (ASK) digital modulation technique. Further, the impedance-based model is developed to analyze the interference between the power and high-frequency information signals. The inductive power and data transfer (IPDT) prototype is developed in the laboratory and results show that the data rate reaches 288 kbps when 46.6 W of power is transferred from source to load.
In vitro seed germination of Paphiopedilum lowii, an endangered slipper orchid in North Borneo
Authors: RAGU VINISHAA S. , OMBOKOU ROSLIN , REPIN RIMI , MOLIDIN DUNI , MIADIN RAMLAN , AZIZ ZALEHA A.
Published: January 2023

Abstract. Ragu VS, Ombokou R, Repin R, Molidin D, Miadin R, Aziz ZA. 2022. In vitro seed germination of Paphiopedilum lowii, an endangered slipper orchid in North Borneo. Biodiversitas 23: 5687-5694. Paphiopedilum lowii (Lindl.) Stein is alarmingly decreasing in numbers due to habitat destruction and over-collection. Propagation through seed is one effort to conserve the species. In vitro method offers better results for seed germination in orchids, but the success of germination is species-specific. Hence, this research aimed to evaluate different types of media [(½ strength Murashige & Skoog and Orchimax Medium (Duchefa Biochemie)], and to determine the effects of sucrose [0% 1%, 2% and 3% (w/v)], peptone [0%, 0.1% and 0.2% (w/v)], coconut water [0%, 10%, 20% and 30% (v/v)] and fertilizer [Orchid Focus - 0%, 0.1% and 0.2% (v/v)] on seed germination. The protocorm size was also determined after 12 weeks of observation. Half-strength MS media consistently gave higher seed germination, ½ MS supplemented with 1% (w/v) sucrose, 0.1% (w/v) peptone, 0% (v/v) coconut water and 0.1 % (v/v) fertilizer resulted in the highest seed germination at 5.32% ± 5.9, 19.27% ± 9.34, 11.33% ± 3.80 and 19.31% ± 9.03 respectively. Despite being 12 weeks in culture, the sizes of the protocorms are small (0.222±0.089 mm diameter, 0.703±0.280 mm circumference, and 0.045±0.043 mm2 area); this requires future investigation. These findings can serve as base information for further enhancement of seed germination and development of propagation methods of P. lowii for use in a conservation program.
Profile of Multidrug Resistance and Methicillin-Resistant Staphylococcus aureus (MRSA) isolated from cats in Surabaya, Indonesia
Authors: AFNANI DANIAH ASHRI , FATIH NURULLAH , EFFENDI MUSTOFA HELMI , TYASNINGSIH WIWIEK , KHAIRULLAH ASWIN RAFIF , KURNIAWAN SHENDY CANADYA , SILAEN OTTO SAHAT MARTUA , RAMANDINIANTO SANCAKA CHASYER , WIDODO AGUS , RIWU KATTY HENDRIANA PRISCILIA
Published: January 2023

Abstract. Afnani DA, Fatih N, Effendi MH, Tyasningsih W, Kairullah AR, Kurniawan SC, Silaen OSM, Ramandianto SC, Widodo A, Hendriana K, Riwu KHP. 2022. Profile of Multidrug Resistance and Methicillin-Resistant Staphylococcus aureus (MRSA) isolated from cats in Surabaya, Indonesia. Biodiversitas 23: 5703-5709. Methicillin-Resistant Staphylococcus aureus (MRSA) is the name given to Staphylococcus aureus that has multidrug-resistance (MDR) characteristics and is resistant to ?-lactam drugs. Compared to other livestock, companion animals have been mentioned as potential MRSA reservoirs more frequently. This study aimed to identify MDR and detects MRSA strains from cats in Surabaya. A total of 150 nasal swab of cats were taken from several clinics and veterinary hospital. Samples were swabbed using Amies Medium Transport then identified using microbiological standard method. Kirby-Bauer diffusion method was performed for S. aureus antibiotic resistance profile on five different antibiotic discs. As a confirmatory test for MRSA, S. aureus isolates that were resistant to cefoxitin continued to grow on Oxacillin Resistance Screening Agar Base (ORSAB). The findings of the isolation and identification and process revealed 18 (12%) S. aureus isolates. The antibiotic resistance test revealed 3 (2%) MDR S. aureus isolates and 4 (2.6%) MDR S. aureus isolates that were ORSAB positive. It has been discovered that there are MDR and MRSA S. aureus isolates. It could be used as an indicator of irrational usage of antibiotics and it explained that cats could be source of infection to public health.
Bacteria communities of coffee plant rhizosphere and their potency as plant growth promoting
Authors: SUHARJONO SUHARJONO , YULIATIN ERVINDA
Published: January 2023

Abstract. Suharjono, Yuliatin E. 2022. Bacteria communities of coffee plant rhizosphere and their potency as plant growth promoting. Biodiversitas 23: 5822-5834. This study aimed to investigate the soil bacteria communities of the coffee rhizosphere and evaluate the potency in supporting coffee plant growth. The soil was collected from the Coffea canephora and Coffea arabica in Malang, East Java. The bacterial genomic DNA was extracted by FastDNA Spin kit while the Illumina platform analyzed the total gDNA. Other samples were isolated using the serial dilution method on Tryptic Soy Agar, Pikovskaya Agar, and Nitrogen-free-Bromothymol Blue Agar medium to isolate IAA-producing, phosphate-solubilizing, and nitrogen-fixing bacteria, respectively. The selected bacteria isolates were identified based on 16S rDNA sequencing. As a result, the Proteobacteria showed dominance at the phyla level, and Bradyrhizobium elkanii was the most abundant species with a not significant different proportion between Robusta and Arabica soil. The quantifying method of the selected isolate showed the maximum concentration, such as S1.6.3.2 isolate producing IAA-hormone at 104.46 µg/mL, W3.5 isolate solubilizing the phosphate at 4.5 µg/mL, and W1.2 isolate fixing the ammonia at 21.54 µg/mL. Those potential isolates, S1.6.3.2, W3.5, and W1.2, were identified as Bacillus subtilis DSM 10, Pseudomonas putida S18, and Bacillus methylotropicus SY2, respectively. Further research shows that those bacteria consortiums can be a candidate as biofertilizers due to helping soil health stimulation and promoting coffee growth.
Ethnobotanical study and conservation strategy of medicinal plants in the ecotourism area of Kedah Rainforest Lodges in Aceh, Indonesia
Authors: RIDWAN RIDWAN , ZAHRAH MA'RIFATIN , RAHMAWATY RAHMAWATY
Published: January 2023

Abstract. Ridwan, Zahrah M, Rahmawaty. 2022. Ethnobotanical study and conservation strategy of medicinal plants in the ecotourism area of Kedah Rainforest Lodges in Aceh, Indonesia. Biodiversitas 23: 6227-6237. Medicinal plants have long been used by indigenous communities, including Gayo people in Aceh, Indonesia. The conservation and sustainable utilization of medicinal plants can be integrated with ecotourism activities. Kedah Rainforest Lodges is an ecotourism area in the Protected Forest area of Forest Management Unit (FMU) Region V Aceh, Indonesia, which is an important source of medicinal plants, clean water and nature tourism. However, biodiversity in the area is threatened by excessive human activity, including the long-standing tradition of Gayo people using medicinal plants. Therefore, this study aimed to investigate medicinal plants used by the local community living around Kedah Rainforest Lodges using an ethnobotanical approach and to identify a strategy for the conservation of medicinal plants using strengths, weaknesses, opportunities and threats (SWOT) analysis. A combination of field observations, interviews, documentation and focus group discussions were employed for data collection. The result of the ethnobotanical study identified 44 species belonging to 31 families of medicinal plants used by Gayo people in the studied area. Asteraceae is the family with the largest number of medicinal plant species, while herbs are the most common habitus of the medicinal plants and leaves are the most used plant part. Based on SWOT analysis, there are several strategies to conserve medicinal plants in Kedah Rainforest Lodges, including (i) the rehabilitation of degraded areas through the enrichment of medicinal plants to create living pharmacies; (i) the development of facilities to support medicinal plants ecotourism; and (iii) partnerships with related stakeholders to obtain funding and enhance the capacity of the area manager and staff.