bluuebunny/crossref_metadata_2025 huggingface dataset:
Spatiotemporal variation and driving force of gully erosion in the Pisha sandstone area
Authors: Zhang Yu , Li Long , Liu Linfu , Zhang Shangxuan , Zhao Wenzhuo , Ren Yanan , Yang Yue
Published: September 2024

The experiment was conducted on gully slopes with slopes ranging from 80° to 90° to investigate the relationship between erosion rates, spatial and temporal changes in microtopography, and drivers of erosion on gully slopes in different seasons. To precisely characterize the microtopography of slopes where debris slides occur, we used the RIEGL VZ-400 3D laser scanner to scan the observation site and acquire point cloud data on the slope’s microtopography. Using the “data conversion module” of ArcGIS software, the point cloud data were transformed into raster data. Through the “3D analysis,” “hydrological analysis,” and “grid calculator” modules, the basic microgeomorphological indicators were extracted from the gully slope grid data, and the erosion rate and microterrain evolution mechanism of the gully slope in different seasons were also determined. The results revealed the following: (1) in the Pisha sandstone area, erosion was relatively strong in the first quarter, with 65% of the area being eroded. The average erosion rates over the four quarters followed the order of first quarter > fourth quarter > second quarter > third quarter, from fastest to slowest. (2) As the soil on the gully slope thawed, melt water increased soil moisture. This phenomenon sharply increased surface roughness in the first quarter. The correlation coefficients between the erosion rate and temperature in the first and fourth quarters were 0.75 and 0.82, respectively. Temperature mainly affected the erosion rate through surface roughness. The direct path coefficient of this effect was 0.72. (3) In the first and fourth quarters, temperature and wind speed were the main factors influencing the erosion rate; the relationship between surface roughness and other factors was evident, making surface roughness the best topographic factor for assessing slope erosion in the Pisha sandstone area. The results of this study aim to provide theoretical references for understanding the gravity erosion mechanism of gully slopes in the Pisha sandstone area and contribute to the high-quality development of the Yellow River Basin.
The impact of forestry management practices on regional economic benefits and livelihood of the rural communities in Ghana: a case study of three forest reserves in the Ashanti region
Authors: Ampadu Prince Boateng , Yang Jiameng
Published: September 2024

Over the past years, forests have been crucial in shaping economic development patterns by sustaining livelihoods, assisting in economic restructuring, and encouraging sustainable growth. This study assesses the impact of forestry management practices on regional economic benefits and the livelihoods of rural communities in Ghana, focusing on three forest reserves in the Ashanti Region. A mixed-method research design, incorporating both quantitative and qualitative approaches, was employed. A total of 234 respondents were purposively selected based on their availability and willingness to respond to questions, with data collected using a semi-structured questionnaire. The findings indicate a notable improvement in the standard of living, measured by four indicators: household finances, food security, physical health, and social indicators. Despite these improvements, a significant decrease in forest cover was observed in recent years. The decline in forest cover around the three forest reserves in the Ashanti Region of Ghana was attributed to poor management. Communities reported inadequate management and enforcement of forest policies, with forest managers not adhering to regulations, showing high levels of corruption, a trend consistent in 2017 (58.9%) and 2023 (60%). In summary, there has been a significant improvement in the livelihoods of rural communities around the Tano Offin, Nkrabia, and Afram Headwaters forest reserves in the Ashanti Region of Ghana. However, the management of forest resources remains poor and inefficient, leading to a substantial loss of forest cover. This loss threatens biodiversity and ecosystem services. The government should implement proactive forestry management strategies and promote community-based approaches to enhance community involvement in managing their forest resources.
Huang Lian Jie Du decoction attenuated colitis via suppressing the macrophage Csf1r/Src pathway and modulating gut microbiota
Authors: Su Shan , Liu Ting , Zheng Jia-Yi , Wu Hai-Cui , Keng Vincent W. , Zhang Shi-Jie , Li Xiao-Xiao
Published: September 2024

Introduction

Ulcerative colitis, a subtype of chronic inflammatory bowel disease (IBD), is characterized by relapsing colonic inflammation and ulcers. The traditional Chinese herbal formulation Huang Lian Jie Du (HLJD) decoction is used clinically to treat diarrhea and colitis. However, the mechanisms associated with the effects of treatment remain unclear. This study aims to elucidate the molecular mechanistic effects of HLJD formulation on colitis.

Methods

Chronic colitis in mice was induced by adding 1% dextran sulfate sodium (DSS) to their drinking water continuously for 8 weeks, and HLJD decoction at the doses of 2 and 4 g/kg was administered orally to mice daily from the second week until experimental endpoint. Stool consistency scores, blood stool scores, and body weights were recorded weekly. Disease activity index (DAI) was determined before necropsy, where colon tissues were collected for biochemical analyses. In addition, the fecal microbiome of treated mice was characterized using 16S rRNA amplicon sequencing.

Results

HLJD decoction at doses of 2 and 4 g/kg relieved DSS-induced chronic colitis in mice by suppressing inflammation through compromised macrophage activity in colonic tissues associated with the colony-stimulating factor 1 receptor (Csf1r)/Src pathway. Furthermore, the HLJD formula could modify the gut microbiota profile by decreasing the abundance of Bacteroides, Odoribacter, Clostridium_sensu_stricto_1, and Parasutterella. In addition, close correlations between DAI, colon length, spleen weight, and gut microbiota were identified.

Discussion

Our findings revealed that the HLJD formula attenuated DSS-induced chronic colitis by reducing inflammation via Csf1r/Src-mediated macrophage infiltration, as well as modulating the gut microbiota profile.
The involvement of HDAC3 in the pathogenesis of lung injury and pulmonary fibrosis
Authors: Yu Hanming , Liu Shi , Wang Shuo , Gu Xiu
Published: September 2024

Acute lung injury (ALI) and its severe counterpart, acute respiratory distress syndrome (ARDS), are critical respiratory conditions with high mortality rates due primarily to acute and intense pulmonary inflammation. Despite significant research advances, effective pharmacological treatments for ALI and ARDS remain unavailable, highlighting an urgent need for therapeutic innovation. Notably, idiopathic pulmonary fibrosis (IPF) is a chronic, progressive disease characterized by the irreversible progression of fibrosis, which is initiated by repeated damage to the alveolar epithelium and leads to excessive extracellular matrix deposition. This condition is further complicated by dysregulated tissue repair and fibroblast dysfunction, exacerbating tissue remodeling processes and promoting progression to terminal pulmonary fibrosis. Similar to that noted for ALI and ARDS, treatment options for IPF are currently limited, with no specific drug therapy providing a cure. Histone deacetylase 3 (HDAC3), a notable member of the HDAC family with four splice variants (HD3α, -β, -γ, and -δ), plays multiple roles. HDAC3 regulates gene transcription through histone acetylation and adjusts nonhistone proteins posttranslationally, affecting certain mitochondrial and cytoplasmic proteins. Given its unique structure, HDAC3 impacts various physiological processes, such as inflammation, apoptosis, mitochondrial homeostasis, and macrophage polarization. This article explores the intricate role of HDAC3 in ALI/ARDS and IPF and evaluates its therapeutic potential the treatment of these severe pulmonary conditions.
Causal effect of thyroid cancer on secondary primary malignancies: findings from the UK Biobank and FinnGen cohorts
Authors: Wang Zhengshi , Rixiati Youlutuziayi , Jia Chengyou , Xu Yong , Yin Zhiqiang , Huang Junwen , Dai Jiaqi , Zhang Yun
Published: September 2024

Background

Existing epidemiological data indicated a correlation between thyroid cancer (THCA) and the risk of secondary primary malignancies (SPMs). However, the correlation does not always imply causality.

Methods

The Mendelian randomization (MR) analyses were performed to investigate the causal relationships between THCA and SPMs based on international multicenter data. Odds ratios (ORs) with 95% confidence intervals (95% CIs) were calculated. The Cancer Genome Atlas (TCGA) was used to explore potential mechanisms shared by THCA and bladder cancer (BLCA).

Results

Summary datasets of genome-wide association studies (GWAS) on 30 types of cancers were obtained from the United Kingdom Biobank (UKB) and FinnGen database. Meta-analysis of the UKB and FinnGen results revealed that THCA was significantly positively correlated with BLCA (OR = 1.140; 95% CI, 1.072-1.212; P < 0.001). Four genes, including WNT3, FAM171A2, MLLT11, and ULBP1, were identified as key genes shared by both TCHA and BLCA. Correlation analysis indicated that THCA may increase the risk of secondary BLCA through augmentation of N2 neutrophil infiltration.

Conclusions

This study showed that THCA was causally related to BLCA. It is recommended to conduct more rigorous screenings for BLCA during the follow-up of THCA patients.
Liquid-liquid phase separation: a new perspective on respiratory diseases
Authors: Wang Li , Wang Yongjun , Ke Zhangmin , Wang Zexu , Guo Yufang , Zhang Yunlei , Zhang Xiuwei , Guo Zhongliang , Wan Bing
Published: September 2024

Liquid-liquid phase separation (LLPS) is integral to various biological processes, facilitating signal transduction by creating a condensed, membrane-less environment that plays crucial roles in diverse physiological and pathological processes. Recent evidence has underscored the significance of LLPS in human health and disease. However, its implications in respiratory diseases remain poorly understood. This review explores current insights into the mechanisms and biological roles of LLPS, focusing particularly on its relevance to respiratory diseases, aiming to deepen our understanding and propose a new paradigm for studying phase separation in this context.
ERK1/2 regulates melanin synthesis in fish: a case study on a colourful variety, leopard coral grouper (Plectropomus leopardus)
Authors: Yang Min , Huang Jie , Zheng Decai , Tang Haizhan , Liu Junchi , Luo Jian , Wen Xin
Published: September 2024

Understanding the molecular mechanism of melanogenesis in Plectropomus leopardus is important for exploring the pattern of skin colour variation in grouper. The research team conducted a combined transcriptomic and proteomic analysis of P. leopardus skin tissues in red-skinned and black-skinned fish and found that the common differences were reflected in the melanogenesis pathway. Therefore, to further investigate the molecular mechanism of melanogenesis in P. leopardus, the full-length sequences of the erk1/2 and mitf genes were obtained in this study using the RACE technique. Through structure-function analysis and differential expression in different red-skinned and black-skinned P. leopardus tissues, it was found that the MAPK signalling pathway may be involved in skin colour changes in P. leopardus, and when erk1/2 expression was decreased in P. leopardus, mitf expression increased accordingly. On the one hand, through short-term in vivo injection of erk1/2-dsRNA, the optimal interference primer for experimented fish was found to be group D: F2R1(F2: TAATACGACTCACTATAGGGATCAACGACATTCTCAGGGC; R1: TAATACGACTCACTATAGGGTCCATGGAGAAAGTGAAGGG), the optimal injection site was the tail vein, the optimal interference concentration was 5 µg/g, and the duration of the interference effect was 5 days. The results of long-term interference showed that when erk1/2 expression was decreased in P. leopardus, the skin colour of the treats fish then darkened, which indicated that ERK1/2 was involved in the regulation of melanogenesis. On the other hand, in vitro Co-Immunoprecipitation (Co-IP) results showed that there was a direct or indirect interaction between MITF and ERK1/2 proteins. In conclusion, this is the first time that an interaction between ERK1/2 and MITF, which indicated that ERK1/2 was involved in the regulation of melanogenesis through the regulation of MITF in P. leopardus. These results further enrich our understanding of the theoretical basis of the changing pattern of skin colour in P. leopardus and provides a new perspective for exploring the variable skin colouration of coral reef fish.
CT-guided joint cavity release for postpartum sacroiliac joint pain management: an evaluation of its efficacy, safety, and clinical outcomes
Authors: Mao-jiang Yang , Xian Qiong , Bhetuwal Anup , Bing Li , Xiao-xue Xu
Published: September 2024

Objective

The central aim of this study was to evaluate the safety and effectiveness of Computed Tomography (CT)-guided joint cavity release in treating patients suffering from postpartum sacroiliac joint pain.

Methods

A retrospective analysis was conducted on a sample of 37 patients who presented with postpartum sacroiliac joint pain and underwent CT-guided sacroiliac joint release treatment at The Affiliated Hospital of North Sichuan Medical College. General clinical attributes of the patients were recorded, and the intensity of their pain before and after the operation was compared using the Numeric Pain Rating Scale (NRS). The effectiveness of the surgical treatment was assessed using the Modified MacNab criteria. The functional status of the sacroiliac joint at 3-and 6-month intervals post-operation was examined, and any complications related to surgery were documented.

Results

The follow-up period was completed by all patients, with the successful implementation of CT-guided unilateral/bilateral sacroiliac joint release undertaken in 37 patients. Patient reported pain, as measured by the Numeric Pain Rating Scale (NRS), was considerably reduced postoperatively with scores showing significant decrement from 7.14 ± 1.23 preoperatively to 1.26 ± 0.53 at 1 week, 1.86 ± 0.62 at 1 month, 1.92 ± 0.48 at 3 months, and 1.97 ± 0.61 at 6 months postoperatively, respectively (p < 0.05). The comprehensive record of treatment response rates, interpreted as excellent and good, were consistent, standing at 100% (37/37), followed by 97.30% (35/37) and concluding with 91.89% (33/37). The Oswestry Disability Index (ODI) scores reflecting the patient’s perceived level of disability prior to the surgery, and at 3 and 6 month intervals post-surgery were 45.12 ± 6.01, 18.14 ± 2.23, and 14.25 ± 2.15, respectively, demonstrating a significant improvement in postoperative scores when compared with preoperative scores (p < 0.05). The surgeries conducted were devoid of any complications such as bleeding, infection, cardiovascular or cerebrovascular incidents, or decline in joint functionality in any of the patients.

Conclusion

Evidently, CT-guided joint cavity release presents as an effective therapeutic approach for the management of postpartum sacroiliac joint pain, enhancing quality of life and preserving patient safety.
Case Report: The first case of successful pregnancy and live birth following laparoscopic resection of adenomyosis under real-time intraoperative ultrasound elastography guidance
Authors: Ota Yoshiaki , Ota Kuniaki , Takahashi Toshifumi , Horikawa Naoki , Kuroda Ryosuke , Okamoto Hana , Tanaka Yu , Kusumoto Tomoyuki , Oda Takashi , Matsuyama Takehiko , Miyake Takahito , Honda Tetsuro , Shimoya Koichiro
Published: September 2024

Objective

Adenomyosis-related infertility is increasingly being diagnosed, and surgical intervention has been suggested to improve fertility. Elastography, a noninvasive ultrasound technique, is promising for diagnosing and guiding the resection of adenomyosis. This report presents the first case of successful delivery after twin pregnancies achieved with IVF following intraoperative elastography-guided laparoscopic adenomyomectomy.

Case report

A 35-year-old Japanese woman with uterine adenomyosis received a gonadotropin analog before surgery. Preoperative MRI revealed a 5.0 × 7.0 cm adenomyoma, leading to scheduled laparoscopic adenomyomectomy with intraoperative elastography. During surgery, elastography ensured the complete resection of the adenomyotic tissue while preserving the endometrium. Postoperative MRI confirmed the absence of residual adenomyosis. The patient underwent in vitro fertilization and embryo transfer, leading to a successful twin pregnancy after double blastocyst transfer. Despite a stable perinatal course, she required hospitalization to prevent preterm labor. At 32 weeks, an elective cesarean section delivered healthy twins. The intra- and post-operation was uncomplicated, and the patient and infants had an optimal health.

Conclusion

This is the first reported case of a twin pregnancy resulting from vitrified-warmed embryo transfer after elastography-guided laparoscopic adenomyomectomy, culminating in a successful delivery via cesarean section. This technique allows precise resection and mitigates the risks of uterine rupture and placenta accreta spectrum disorders. Although promising, further studies are required to validate the safety and efficacy of this innovative surgical approach.
The association between the gut microbiota metabolite trimethylamine N-oxide and heart failure
Authors: Jarmukhanov Zharkyn , Mukhanbetzhanov Nurislam , Kozhakhmetov Samat , Nurgaziyev Madiyar , Sailybayeva Aliya , Bekbossynova Makhabbat , Kushugulova Almagul
Published: September 2024

This systematic review explores the relationship between the gut microbiota metabolite trimethylamine N-oxide (TMAO) and heart failure (HF), given the significant impact of TMAO on cardiovascular health. A systematic search and meta-analysis of peer-reviewed studies published from 2013 to 2024 were conducted, focusing on adult patients with heart failure and healthy controls. The review found that elevated levels of TMAO are associated with atherosclerosis, endothelial dysfunction, and increased cardiovascular disease risk, all of which can exacerbate heart failure. The analysis also highlights that high TMAO levels are linked to reduced left ventricular ejection fraction (LVEF) and glomerular filtration rate (GFR), further supporting TMAO’s role as a biomarker in heart failure assessment. The findings suggest that interventions targeting gut microbiota to reduce TMAO could potentially benefit patients with heart failure, although further research is needed to evaluate the effectiveness of such approaches.
Sleep improves accuracy, but not speed, of generalized motor learning in young and older adults and in individuals with Parkinson’s disease
Authors: Lanir-Azaria Saar , Chishinski Rakefet , Tauman Riva , Nir Yuval , Giladi Nir
Published: September 2024

An essential aspect of motor learning is generalizing procedural knowledge to facilitate skill acquisition across diverse conditions. Here, we examined the development of generalized motor learning during initial practice-dependent learning, and how distinct components of learning are consolidated over longer timescales during wakefulness or sleep. In the first experiment, a group of young healthy volunteers engaged in a novel motor sequence task over 36 h in a two-arm experimental design (either morning-evening-morning, or evening-morning-evening) aimed at controlling for circadian confounders. The findings unveiled an immediate, rapid generalization of sequential learning, accompanied by an additional long-timescale performance gain. Sleep modulated accuracy, but not speed, above and beyond equivalent wake intervals. To further elucidate the role of sleep across ages and under neurodegenerative disorders, a second experiment utilized the same task in a group of early-stage, drug-naïve individuals with Parkinson’s disease and in healthy individuals of comparable age. Participants with Parkinson’s disease exhibited comparable performance to their healthy age-matched group with the exception of reduced performance in recalling motor sequences, revealing a disease-related cognitive shortfall. In line with the results found in young subjects, both groups exhibited improved accuracy, but not speed, following a night of sleep. This result emphasizes the role of sleep in skill acquisition and provides a potential framework for deeper investigation of the intricate relationship between sleep, aging, Parkinson’s disease, and motor learning.
The effect of brain-computer interface controlled functional electrical stimulation training on rehabilitation of upper limb after stroke: a systematic review and meta-analysis
Authors: Ren Chunlin , Li Xinmin , Gao Qian , Pan Mengyang , Wang Jing , Yang Fangjie , Duan Zhenfei , Guo Pengxue , Zhang Yasu
Published: September 2024

Introduction

Several clinical studies have demonstrated that brain-computer interfaces (BCIs) controlled functional electrical stimulation (FES) facilitate neurological recovery in patients with stroke. This review aims to evaluate the effectiveness of BCI-FES training on upper limb functional recovery in stroke patients.

Methods

PubMed, Embase, Cochrane Library, Science Direct and Web of Science were systematically searched from inception to October 2023. Randomized controlled trials (RCTs) employing BCI-FES training were included. The methodological quality of the RCTs was assessed using the PEDro scale. Meta-analysis was conducted using RevMan 5.4.1 and STATA 18.

Results

The meta-analysis comprised 290 patients from 10 RCTs. Results showed a moderate effect size in upper limb function recovery through BCI-FES training (SMD = 0.50, 95% CI: 0.26–0.73, I2 = 0%, p < 0.0001). Subgroup analysis revealed that BCI-FES training significantly enhanced upper limb motor function in BCI-FES vs. FES group (SMD = 0.37, 95% CI: 0.00–0.74, I2 = 21%, p = 0.05), and the BCI-FES + CR vs. CR group (SMD = 0.61, 95% CI: 0.28–0.95, I2 = 0%, p = 0.0003). Moreover, BCI-FES training demonstrated effectiveness in both subacute (SMD = 0.56, 95% CI: 0.25–0.87, I2 = 0%, p = 0.0004) and chronic groups (SMD = 0.42, 95% CI: 0.05–0.78, I2 = 45%, p = 0.02). Subgroup analysis showed that both adjusting (SMD = 0.55, 95% CI: 0.24–0.87, I2 = 0%, p = 0.0006) and fixing (SMD = 0.43, 95% CI: 0.07–0.78, I2 = 46%, p = 0.02). BCI thresholds before training significantly improved motor function in stroke patients. Both motor imagery (MI) (SMD = 0.41 95% CI: 0.12–0.71, I2 = 13%, p = 0.006) and action observation (AO) (SMD = 0.73, 95% CI: 0.26–1.20, I2 = 0%, p = 0.002) as mental tasks significantly improved upper limb function in stroke patients.

Discussion

BCI-FES has significant immediate effects on upper limb function in subacute and chronic stroke patients, but evidence for its long-term impact remains limited. Using AO as the mental task may be a more effective BCI-FES training strategy.

Systematic review registration

Identifier: CRD42023485744, https://www.crd.york.ac.uk/prospero/display_record.php?ID=CRD42023485744.
The role of the gut microbiota in neurodegenerative diseases targeting metabolism
Authors: Fu Yufeng , Gu Zhongya , Cao Huan , Zuo Chengchao , Huang Yaqi , Song Yu , Jiang Yongsheng , Wang Furong
Published: September 2024

In recent years, the incidence of neurodegenerative diseases (NDs) has gradually increased over the past decades due to the rapid aging of the global population. Traditional research has had difficulty explaining the relationship between its etiology and unhealthy lifestyle and diets. Emerging evidence had proved that the pathogenesis of neurodegenerative diseases may be related to changes of the gut microbiota’s composition. Metabolism of gut microbiota has insidious and far-reaching effects on neurodegenerative diseases and provides new directions for disease intervention. Here, we delineated the basic relationship between gut microbiota and neurodegenerative diseases, highlighting the metabolism of gut microbiota in neurodegenerative diseases and also focusing on treatments for NDs based on gut microbiota. Our review may provide novel insights for neurodegeneration and approach a broadly applicable basis for the clinical therapies for neurodegenerative diseases.
Case report: Dynamic 18F-FDG PET/CT display of a bronchial mass as a second primary cancer mimicking mediastinal lymph node in a gastric carcinoma survivor
Authors: Huang Shengyun , Zhang Yarong , Wumener Xieraili , Lei Yuanyuan , Liang Ying
Published: September 2024

A 70-year-old woman underwent distal gastrectomy due to gastric adenocarcinoma in 2015. After 6 years, the follow-up CT revealed a suspicious mass in the right hilar of the lung mimicking mediastinal lymph nodes. Further dynamic PET/CT images showed a mass located in the right intermediate bronchus with increased FDG uptake and relatively high Ki value, which may imply the possibility of malignancy. However, the symmetrical mediastinal lymph nodes had intense FDG uptake but relatively low Ki value, suggesting benign lesions. The initial pathological result of the bronchoscopy biopsy was considered suspicious for metastatic gastric adenocarcinoma. However, it was then found consistent with middle-grade mucoepidermoid carcinoma, considered a second primary cancer without metastatic lymph nodes as confirmed by a surgical procedure (lower bilobectomy + hilar and mediastinal lymphadenectomy). 18F-FDG PET/CT has an important value in the follow-up of indeterminate findings for patients with a tumor history. Moreover, dynamic quantification parameters such as Ki may be additionally helpful in identifying malignancies in some equivocal situations.
The impact of statin use on short-term and long-term mortality in patients with heart failure
Authors: Zheng Xiaoxue , Tan Long , Zhang Yu
Published: September 2024

Background

Heart failure (HF) is a complex disorder that has an association with increased morbidity and mortality rates globally. The association of statin use with mortality rate in individuals with HF remains unclear.

Objectives

To examine the association of statin use with the short-term and long-term all-cause mortality rate in critically ill individuals with HF.

Methods

We performed a retrospective cohort analysis based on the Medical Information Mart for Intensive Care (MIMIC)-IV database. The critically ill people with HF were assigned to a statin group and a non-statin group according to whether they had been treated with statin or not during hospitalization. The Kaplan−Meier (KM) method and Cox proportional hazard models were adopted to explore the link between statin administration and the 30-day, 90-day, as well as 1-year mortality rates. To ensure the robustness of the findings, a 1:1 nearest propensity-score matching (PSM) was also performed.

Results

The current research included 11,381 patients for the final analysis, with 7,561 in the statin group and 3,820 in the non-statin group. After multiple confounders were adjusted, we found that the Cox regression models revealed great beneficial effects of statin therapy on the 30-day, 90-day, as well as 1-year mortality rates among critically ill individuals with HF in the fully adjusted model. PSM also achieved consistent results. After PSM, the risk of mortality reduced by 23% for the 30-day mortality (HR = 0.77, 95%CI: 0.68–0.88, p < 0.001), 16% for the 90-day mortality rate (HR = 0.84, 95%CI: 0.75–0.93, p < 0.001), and 12% for the 1-year mortality rate (HR = 0.88, 95%CI: 0.81–0.97, p = 0.007). Patients treated with rosuvastatin had the greatest reduction in mortality rate. The 30-day, 90-day, and 1-year all-cause mortality rates were remarkably lower in patients who were treated with low-dose statins.

Conclusion

Our study unveiled that statin use was related to decreased short-term and long-term all-cause mortality rates in critically ill individuals with HF. Rosuvastatin was associated with the greatest reduction of all-cause mortality rates. Low-dose statins can significantly reduce short-term and long-term mortality, while high-dose statins are not significantly correlated with mortality. However, the results are not conclusive and should be interpreted with caution.
Deletion of arrestin-3 does not reduce drug-seeking behavior in a longitudinal paradigm of oral morphine self-administration
Authors: Gooding Sarah Warren , Felth Lindsey , Foxall Randi , Rosa Zachary , Ireton Kyle , Sall Izabella , Gipoor Joshua , Gaur Anirudh , King Madeline , Dirks Noah , Whistler Cheryl Allyne , Whistler Jennifer Lynne
Published: September 2024

Introduction

Opioid drugs are potent analgesics that mimic the endogenous opioid peptides, endorphins and enkephalins, by activating the µ-opioid receptor. Opioid use is limited by side effects, including significant risk of opioid use disorder. Improvement of the effect/side effect profile of opioid medications is a key pursuit of opioid research, yet there is no consensus on how to achieve this goal. One hypothesis is that the degree of arrestin-3 recruitment to the µ-opioid receptor impacts therapeutic utility. However, it is not clear whether increased or decreased interaction of the µ-opioid receptor with arrestin-3 would reduce compulsive drug-seeking.

Methods

We utilized three genotypes of mice with varying abilities to recruit arrestin-3 to the µ-opioid receptor in response to morphine in a novel longitudinal operant self-administration model. We also created a quantitative method to define compulsivity in drug-seeking based on a multi-variate analysis of several operant response variables.

Results

We demonstrate that arrestin-3 knockout and wild type mice have highly variable drug-seeking behavior with few genotype differences. In contrast, in mice where the µ-opioid receptor strongly recruits arrestin-3, drug-seeking behavior is much less varied. We found that mice lacking arrestin-3 were more likely to meet the criteria for compulsivity whereas mice with enhanced arrestin-3 recruitment did not develop a compulsive phenotype.

Conclusion

These experiments show that a lack of arrestin-3 is not protective against the abuse liability of morphine in an operant self-administration context. Our data also suggest that opioids that engage both G protein and arrestin-3, recapitulating the endogenous signaling pattern, will reduce abuse liability.
Erbin: an important therapeutic target for blocking tumor metastasis
Authors: Qiu Tingting , Tan Liquan , Yan Jialong , Luo Qunli
Published: September 2024

Erbin is an adapter protein that interacts with the v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2 (ERBB2) in epithelial cells. Erbin plays an important role in various signaling pathways, including cell proliferation, apoptosis, and autophagy. Additionally, Erbin is implicated in the pathogenesis and progression of sepsis and various cancers, including breast cancer, acute myeloid leukemia (AML), hepatocellular carcinoma (HCC), and colorectal cancer (CRC). A recent study shows that loss of Erbin increases the release of acyl-carnitine (Acar) through abolishing interaction with prothrombotic protein endothelial cell-specific adhesion molecule (ESAM), promotes mitochondrial oxidative phosphorylation in B cells, and ultimately suppresses lung metastasis of CRC. Accordingly, Erbin provides us with a new potential treatment for tumor metastasis.
Estimation of sorghum seedling number from drone image based on support vector machine and YOLO algorithms
Authors: Chen Hongxing , Chen Hui , Huang Xiaoyun , Zhang Song , Chen Shengxi , Cen Fulang , He Tengbing , Zhao Quanzhi , Gao Zhenran
Published: September 2024

Accurately counting the number of sorghum seedlings from images captured by unmanned aerial vehicles (UAV) is useful for identifying sorghum varieties with high seedling emergence rates in breeding programs. The traditional method is manual counting, which is time-consuming and laborious. Recently, UAV have been widely used for crop growth monitoring because of their low cost, and their ability to collect high-resolution images and other data non-destructively. However, estimating the number of sorghum seedlings is challenging because of the complexity of field environments. The aim of this study was to test three models for counting sorghum seedlings rapidly and automatically from red-green-blue (RGB) images captured at different flight altitudes by a UAV. The three models were a machine learning approach (Support Vector Machines, SVM) and two deep learning approaches (YOLOv5 and YOLOv8). The robustness of the models was verified using RGB images collected at different heights. The R2 values of the model outputs for images captured at heights of 15 m, 30 m, and 45 m were, respectively, (SVM: 0.67, 0.57, 0.51), (YOLOv5: 0.76, 0.57, 0.56), and (YOLOv8: 0.93, 0.90, 0.71). Therefore, the YOLOv8 model was most accurate in estimating the number of sorghum seedlings. The results indicate that UAV images combined with an appropriate model can be effective for large-scale counting of sorghum seedlings. This method will be a useful tool for sorghum phenotyping.
Unveiling the potential applications of buds of Lonicera japonica Thunb. var. chinensis (Wats.) Bak based on in vitro biological activities, bio-active components, and potential applications coupled to targeted metabolomics
Authors: Liu Zhenying , Cheng Yunxia , Xiang Yaoting , Chao Zhimao
Published: September 2024

Introduction

The buds of Lonicera japonica Thunb. var. chinensis (Wats.) Bak, commonly named red honeysuckle, have attracted attention because of their bright colors. However, owing to the lack of systematic studies, the potential applications of red honeysuckle are not clear, and its development and utilization have not been well known.

Methods

In this study, compared with the buds of L. japonica Thunb. (honeysuckle), the potential applications of red honeysuckle were explored based on biological activities, bio-active components, and sensory flavor combined with widely targeted metabolomics.

Results

As a result, in vitro tests showed that it had a stronger antioxidant and a stronger inhibitory effect on the growth of Escherichia coli and Staphylococcus aureus. There was no cytotoxicity on LPS-induced RAW264.7 cells in its aqueous extract using the CCK-8 method. Moreover, it also had a stronger effect on inhibiting the expression of inflammatory factors such as interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), and interleukin-1β (IL-1β). The content of its bio-active components chlorogenic acid and cynaroside was significantly higher (p ≤ 0.001) than that of green honeysuckle. Widely targeted metabolomics analysis revealed that 4 volatile metabolites, such as (E)-4-hexene-1-ol and pyrazole, and 21 non-volatile metabolites, such as macranthoside B and oleanolic acid-3-O-glc(1-2)-(ara)-28-O-glucoside ester, were specific in red honeysuckle. Interestingly, 14 specific terpenoid metabolites were triterpenoid saponins, indicating a stronger biological activity in red honeysuckle. The sensory flavor analysis showed that the red honeysuckle had a stronger herbal and lighter floral flavor.

Discussion

In conclusion, red honeysuckle had great development value with potential applications in medicines, foods, beverages, pigment additives, and health products.
An integrated framework for UAV-based precision plant protection in complex terrain: the ACHAGA solution for multi-tea fields
Authors: Zhang Pengyang , Liu Yangyang , Du Hongbin
Published: September 2024

UAV-based plant protection represents an efficient, energy-saving agricultural technology with significant potential to enhance tea production. However, the complex terrain of hilly and mountainous tea fields, coupled with the limited endurance of UAVs, presents substantial challenges for efficient route planning. This study introduces a novel methodological framework for UAV-based precision plant protection across multiple tea fields, addressing the difficulties in planning the shortest routes and optimal flights for UAVs constrained by their endurance. The framework employs a hyperbolic genetic annealing algorithm (ACHAGA) to optimize UAV plant protection routes with the objectives of minimizing flight distance, reducing the number of turns, and enhancing route stability. The method involves two primary steps: cluster partitioning and sortie allocation for multiple tea fields based on UAV range capabilities, followed by refining the UAV’s flight path using a combination of hyperbolic genetic and simulated annealing algorithms with an adaptive temperature control mechanism. Simulation experiments and UAV route validation tests confirm the effectiveness of ACHAGA. The algorithm consistently identified optimal solutions within an average of 40 iterations, demonstrating robust global search capabilities and stability. It achieved an average reduction of 45.75 iterations and 1811.93 meters in the optimal route, with lower variation coefficients and extreme deviations across repeated simulations. ACHAGA significantly outperforms these algorithms, GA, GA-ACO, AFSA and BSO, which are also heuristic search strategies, in the multi-tea field route scheduling problem, reducing the optimal routes by 4904.82 m, 926.07 m, 3803.96 m and 800.11 m, respectively. Field tests revealed that ACHAGA reduced actual flight routes by 791.9 meters and 359.6 meters compared to manual and brainstorming-based planning methods, respectively. Additionally, the algorithm reduced flight scheduling distance and the number of turns by 11 compared to manual planning. This study provides a theoretical and technical foundation for managing large-scale tea plantations in challenging landscapes and serves as a reference for UAV precision operation planning in complex environments.
High-density genetic map construction and QTL mapping to identify genes for blight defense- and yield-related traits in sesame (Sesamum indicum L.)
Authors: Xu Guizhen , Cui Yanqin , Li Sida , Guan Zhongbo , Miao Hongmei , Guo Yuanzhang
Published: September 2024

Sesame (Sesamum indicum L.) is an important oilseed crop widely cultivated in subtropical and tropical areas. Low genetic yield potential and susceptibility to disease contribute to low productivity in sesame. However, the genetic basis of sesame yield- and disease-related traits remains unclear. Here, we represent the construction of a high-density bin map of sesame using whole genome sequencing of an F2 population derived from ‘Yizhi’ and ‘Mingdeng Zhima’. A total of 2766 Bins were categorized into 13 linkage groups. Thirteen significant QTLs were identified, including ten QTLs related to yield, two QTLs related to Sesame Fusarium wilt (SFW) disease, and one QTL related to seed color. Among these QTLs, we found that SFW-QTL1.1 and SFW-QTL1.2 were major QTLs related to Fusarium wilt disease, explaining more than 20% of the phenotypic variation with LOD > 6. SCC-QTL1.1 was related to seed coat color, explaining 52% of the phenotypic variation with LOD equal to 25.3. This suggests that seed color traits were controlled by a major QTL. Candidate genes related to Fusarium wilt disease and seed color in the QTLs were annotated. We discovered a significant enrichment of genes associated with resistance to late blight. These genes could be spectral disease resistance genes and may have a role in the regulation of Fusarium wilt disease resistance. Our study will benefit the implementation of marker-assisted selection (MAS) for the genetic improvement of disease resistance and yield-related traits in sesame.
Psychological resilience and intention to stay among nurses: the mediating role of perceived organizational support
Authors: Pu Jiangfeng , Wang Waner , Li Gege , Xie Zhanghao , Fan Xuanhao , Zhan Ningjing , Xu Yixuan , Huang Huigen
Published: September 2024

Background

This study aims to analyze the relationship between psychological resilience, perceived organizational support, and intention to stay among nurses. Additionally, it explores the mediating role of perceived organizational support in the relationship between psychological resilience and nurses’ intention to stay.

Methods

A cross-sectional survey was conducted between August and September 2023, involving 1,402 nurses from five Grade 3A hospitals in Guangdong. The survey utilized several instruments, including the General Information Questionnaire (GIQ), the Chinese version of the Connor-Davidson Resilience Scale (CD-RISC), the Chinese version of the Perceived Organizational Support Scale (POSS), and the Chinese version of the Intention to Stay Scale (ITSS). The obtained data were analyzed using descriptive statistics and Pearson’s correlation coefficient, while the mediating effect of perceived organizational support was assessed using the PROCESS macro mediation model in SPSS.

Results

The overall mean score for psychological resilience among nurses in the five Grade 3A hospitals in Guangdong was 60.54 ± 19.17, the overall mean score for perceived organizational support was 45.77 ± 11.49, and the mean score for intention to stay was 20.82 ± 4.65. The results of the statistical analysis revealed positive correlations between psychological resilience and intention to stay (r = 0.388, p < 0.01), between perceived organizational support and psychological resilience (r = 0.570, p < 0.01), and between perceived organizational support and intention to stay (r = 0.550, p < 0.01). Additionally, perceived organizational support was found to mediate the relationship between psychological resilience and intention to stay, with a mediation effect value of 0.067, accounting for 71.28% of the total effect.

Conclusion

Psychological resilience of nursing staff directly impacts their intention to stay and indirectly influences their caring behaviors, with perceived organizational support serving as a key mediator in both relationships. Therefore, nursing managers should implement targeted interventions to enhance nurses’ psychological resilience and perceived organizational support. Strengthening these factors can significantly increase nurses’ intention to stay in their jobs, improve the quality of care, and contribute to building a strong and stable nursing workforce.
Ketogenic diets in clinical psychology: examining the evidence and implications for practice
Authors: Laurent Nicole , Bellamy Erin L. , Hristova Donika , Houston Ally
Published: September 2024

Introduction

The application of ketogenic dietary interventions to mental health treatments is increasingly acknowledged within medical and psychiatric fields, yet its exploration in clinical psychology remains limited. This article discusses the potential implications of ketogenic diets, traditionally utilized for neurological disorders, within broader mental health practices.

Methods

This article presents a perspective based on existing ketogenic diet research on historical use, biological mechanisms, and therapeutic benefits. It examines the potential application of these diets in mental health treatment and their relevance to clinical psychology research and practice.

Results

The review informs psychologists of the therapeutic benefits of ketogenic diets and introduces to the psychology literature the underlying biological mechanisms involved, such as modulation of neurotransmitters, reduction of inflammation, and stabilization of brain energy metabolism, demonstrating their potential relevance to biopsychosocial practice in clinical psychology.

Conclusion

By considering metabolic therapies, clinical psychologists can broaden their scope of biopsychosocial clinical psychology practice. This integration provides a care model that incorporates knowledge of the ketogenic diet as a treatment option in psychiatric care. The article emphasizes the need for further research and training for clinical psychologists to support the effective implementation of this metabolic psychiatry intervention.
Help-seeking behaviors and determinant factors among women exposed to intimate partner violence in East Africa based on recent demographic and health survey data: a multilevel analysis
Authors: Melkam Mamaru , Asnake Angwach Abrham , Mekuria Negussie Yohannes , Bezie Meklit Melaku , Asmare Zufan Alamrie , Asebe Hiwot Altaye , Seifu Beminate Lemma , Fente Bezawit Melak
Published: September 2024

Introduction

Human rights violations and violence against women are serious public health issues that have numerous detrimental repercussions on one’s physical, emotional, sexual, and reproductive health. According to studies, women’s perceptions and traits of violence are highly predictive of their likelihood of seeking help against violence. Even though intimate partner violence is a huge challenge nowadays in Africa, there is a low level of help-seeking behavior. Conducting this study at the East African level on help-seeking behavior can provide a clue for policy-makers. Therefore, this study aimed to reveal the prevalence of help-seeking behavior against intimate partner violence and determinant factors among women in East Africa.

Method

Multilevel logistic regression analysis was carried out among East Africans using recent demographic and health survey data. A total of 7,387 participants aged 15 to 49 years were included in this study from East African countries. Individual- and community-level variables were considered to determine the associated factors with help-seeking behaviors against intimate partner violence with 95% CI and AOR.

Results

The prevalence of help-seeking behavior against intimate partner violence among women was 38.07% with 95% CI (36.96%, 39.18%). Husbands drink alcohol [AOR = 1.46: 95% CI (1.33, 1.61)], women who have work [AOR = 1.33: 95% CI (1.19, 1.50)], and women with higher educational status [AOR = 1.36: 95% CI (1.16, 1.59)] were factors associated with help-seeking behavior against intimate partner violence.

Conclusion

Approximately four out of 10 women were seeking help for intimate partner violence in East Africa. Husbands drinking alcohol, women’s high educational status, and women having occupations were the factors that were associated with help-seeking behaviors against intimate partner violence.
The effectiveness of virtual passport, an app-based intervention, for dementia care
Authors: Hong Qian-Xi , Wang Wen-Fu , Yang Yuan-Han , Tung Yu-Chun , Dai Hong-Jie , Hsu Wen-Chuin , Huang Ling-Chun , Jhang Kai-Ming
Published: September 2024

Background and objectives

This study aimed to confirm the effectiveness of the virtual passport for dementia care.

Research design and methods

The virtual passport is an application (app) tool connecting healthcare professionals, dementia care sites, and people living with dementia (PLWD) and their family caregivers. This tool assists case managers in hospitals by providing individualized care plans and health education to PLWD and their caregivers. The dementia quality indicator achievement rates, care needs investigation and fulfillment, severity of behavioral and psychological symptoms of dementia (BPSD), and changes in caregiver burden and depression are measured at the initial interview and 6 and 12 months after the intervention.

Results

We enrolled 57 and 54 patients and their caregivers in the virtual passport and routine care groups, respectively. Compared to the control group, six quality indicators in the passport group showed significantly higher achievement at 6 months after using the virtual passport. Case managers addressed more care needs at 6 months (1.37 vs 0, p < 0.001) and 12 months (1.32 vs 0, p < 0.001). Improvement in severity of neuropsychiatric symptoms (neuropsychiatric inventory (NPI) irritability/lability difference: -0.58 vs 0.22, p = 0.044; NPI agitation/aggression difference =-0.78 vs 0.00, p = 0.042) were also observed. No obvious influence was found in caregiver burden and depression after using the virtual passport.

Discussion and implications

The virtual passport is an effective information technology tool in improving the quality of dementia care, assisting case management in identifying more care needs, and reducing the severity of BPSD.