bluuebunny/crossref_metadata_2025 huggingface dataset:
A RELEVÂNCIA DA MATEMÁTICA NA TERCEIRA IDADE USANDO TECNOLOGIAS DIGITAIS
Authors: Possamai Ribeiro Elizete Maria
Published: February 2023

Resumo: Este artigo descreve a experiência vivenciada por meio do projeto de extensão denominado Matemática na Terceira Idade desenvolvido por alunos do curso de Licenciatura em Matemática do e supervisionado pela coordenadora do projeto, direcionado a terceira idade do município de Sombrio. O objetivo principal deste projeto é contribuir, por meio do ensino da Matemática a melhora da inclusão social de idosos no município de Sombrio, visando fortalecimento da auto estima, estimular a memória e o desenvolvimento do raciocínio lógico, além de ajudar os alunos em suas dificuldades e mostrar-lhes que a Matemática é uma ciência presente em seu cotidiano e de extrema importância para a compreensão do mundo à sua volta. O desenvolvimento do projeto se deu a partir da utilização de recursos básicos da sala de aula comum, acrescentados de equipamentos de informática em especial o computador e o smartphone, no primeiro momento do projeto ficou evidente alguns avanços no que tange ao conhecimento de alguns conceitos das quatros operações com os números naturais. Notamos certa resistência da parte dos alunos no que se refere a tarefa de buscar ferramentas no computador e smartphone, porém no decorrer das aulas esse processo se tornou natural e os alunos se sentiram a vontade em perguntar e manusear os equipamentos..
Lustro
Authors: Kuran Magdalena , Pawlata Małgorzata , Raźny Joanna , Podwysocka-Modrzejewska Jowita , Poradecki Mateusz , Wypiorczyk Agnieszka
Published: February 2023

W tomie poświęconym motywowi lustra znalazły się artykuły siedmiu badaczy zajmujących się literaturą, językiem i kulturą, pokazujących zagadnienie autopoznania w kontakcie z rekwizytem lustra na przestrzeni wieków. Jako symbol pojawia się ono między innymi w kontekście przekładu, kodów językowych, komunikacyjnych oraz perswazji. […] Pomieszczone w publikacji studia pokazują złożony proces autopoznania, jakiego istota ludzka doświadcza w kontakcie z fizycznym bądź symbolicznym zwierciadłem. Warto sobie zadać pytanie, czy człowiek, patrząc w lustro, co przecież czyni od najdawniejszych czasów, rzeczywiście chce ujrzeć swój prawdziwy obraz. Antropologiczne rozpoznanie tematu daje nam odpowiedź, że przeglądanie się w zwierciadle jest tak naprawdę poszukiwaniem idealnej formy, sposobem ucieczki od świata realnego, a zatem także sposobem wyobcowania się wobec ,ja”. Skoro po drugiej stronie lustra nie ma podmiotu, to czy poszukując „własnego ja”, natykamy się na „własnego innego”?
„Nosce te ipsum” — wprowadzenie do tomu studiów
Authors: Urbańska Monika
Published: February 2023

The introduction to the MIRROR study shows the etymology of the term in different languages (Polish, French, Latin, Greek) and its meaning in different cultures. The mirror is a symbol that can be read on many levels. In interdisciplinary discourse, the mirror functions not only as an object — it is also a symbol of internal reckoning and self-knowledge. In Lacan’s theory, a mirror is a kind of landmark for a child, designating them as a being separate from the environment and controlling their previously disintegrated body. Mirrors on a massive scale were manufactured at the beginning of the 15th century, but they belonged to luxury goods reserved for decorating palaces. Mirror often appeared in folk beliefs, literature and art. In Greek mythology, it was an attribute of Aphrodite — the goddess of beauty, it also became the cause of the misfortune of Narcissus. This subject also inspired painters. In seventeenth-century Europe, the penchant for mirrors was established in interior architecture, painting, philosophy and literature. Contemporary architecture uses a mirror as an important element in creating light and space, as well as a decorative detail that adds modernity. Today, the mirror is still fascinating, installations are exposing the mirror surfaces all over the world. The volume on the MIRROR motif includes articles by seven researchers in literature, language and culture, showing the issue of self-recognition in contact with a mirror prop throughout the ages. As a symbol, the mirror appears, among others, in the context of translation, language, communication codes and persuasion. Interestingly, also elements of nature designed by people of different eras can be read as mirrors reflecting the features of their owners and times.
„[…] iż największa mądrość jest poznać samego siebie” — metafora zwierciadła w kazaniu Gabriela Zawieszki (Leopolity) o św. Marii Magdalenie
Authors: Kuran Magdalena
Published: February 2023

The article presents the sermon of the Dominican preacher Gabriel Zawieszko (Leopolita). The sermon is first from the cycle of ten, concerning St. Mary Magdalene. The preacher uses the concept and the metaphor of a mirror. A mirror is a symbol (at the same time) of a sinful (a mirror of the lust of the flesh, a mirror of the lust of the eyes and a mirror of the pride of life), a penance (nosce te ipsum) and a perfection (Christ — speculum sine macula). Zawieszko also invokes Greek maxim gnothi seauton (Know Thyself). It becomes the guiding thought of the sermon. He connects it with emblematic presentation of mirror (Lascivia, Superbia, Prudentia, Scientia).
Ogród — lustro duszy
Authors: Pawlata Małgorzata
Published: February 2023

Perceiving a garden as a mirror of a soul is the subject taken up by the author in the essay. The writer looks at different conceptions of garden creations from Middle Ages, concentrating on the conceptions of gardens in the age of Enlightenment. The phenomenon of a garden as a mirror of a soul can be analysed with partly architectural and partly philosophical conception of “the memory of gardens” oscillating around three aspects: aesthetics of a garden, philosophy of nature and cosmogony. According to the theory presented in the essay, each garden can be subject to analysis on each level. The author writes about popular in the age of Enlightenment Jean Jacques Rousseau’s beliefs and shows how they have been reflected and how they have evolved in Polish representations of the art of creating gardens.
Dyskurs miłosny "Kochanków" Octave’a Mirbeau: w lustrze przekładu
Authors: Raźny Joanna
Published: February 2023

The aim of the article is to present Octave Mirbeau’s play The Lovers (1904) with regard to the issues of the art of translation. The study is focused entirely on the linguistic and literary methods of how the love discourse is shaped in the play and, within this topic, on the issue of the relationship between feeling and time, the typology of spatial behaviour in the lovers’ interaction, affective nouns, and their role in building intimacy. The theoretical framework is primarily based on literary studies, which include the elements of modern translation study concepts and the achievements of the linguistic research on verbal and non-verbal forms of expressing feelings. The French source text is studied and, with regard to its equivalence, contrasted with its first printed translation — a text in Polish, functioning within the Polish culture and the Polish language. The results of the presented analyses serve, among others, as a justification for the thesis that The Lovers is an intentionally anachronistic play, whose role is to demystify the entanglement of the then-modern conceptualisation about Eros’s affairs with the still romantic patterns and schemas.
Prácticas de la amabilidad: una interpretación del pensamiento de Byung-Chul Han
Authors: Almeyda Juan
Published: February 2023

La presente investigación tiene por objetivo analizar los postuladosfilosófico-políticos presentes en la obra de Byung-Chul Han, con el fin de, pormedio de una exégesis de su pensamiento, proponer el concepto de prácticas deamabilidad como un proyecto ético-político, enfocado en desarrollar lo que el autordenomina una “praxis de la demora”, la cual revitalice la vita contemplativa; encontraposición a la racionalidad neoliberal de corte digital que domina la realidaddesde un modelo de sociedad basado en el rendimiento y la competencia. Paraello, se divide el trabajo en tres momentos: primero, se delimita conceptualmentela sociedad del rendimiento; seguidamente, se expone la propuesta de rebelión deHan a partir del concepto de la revolución del tiempo para, finalmente, exponerla propuesta práctica de su idea de subversión sistémica. Todo esto desde unasistematización analítica de su obra, para lo cual se recurre al método documentalbibliográficode investigación.
Cristóbal Balbontín. Levinas o la posibilidad de un republicanismo libertario. Berlin: Peter Lang, 2021, 208pp.
Authors: Rizo-Patrón de Lerner Rosemary
Published: February 2023

Reseña de Cristóbal Balbontín. Levinas o la posibilidad de un republicanismo libertario.Berlin: Peter Lang, 2021, 208pp.
Fusaric Acid Production by Different Isolates of Fusarium oxysporum f. sp. ciceris and Effect of Selected Culture Filtrate Containing Fusaric Acid on Dynamics of Plant Pigments in Chickpea
Authors: Hamida Dudekula , Kundu Aditi , Kaur Ravpreet , Tripathi Shailesh , Bag Tusar Kanti
Published: February 2023

Background: Biochemical variation with respect to fusaric acid (FA) production by various isolates of Fusarium oxysporum f. sp. ciceris (Foc) was not known and the effect of FA on the pigment dynamics of chickpea was not studied earlier. Methods: The quantity of FA production by 14 isolates of Foc was estimated through HPLC. Further, the effect of culture filtrate (CF) containing FA of ITCC 7682 and ITCC 7681 on the dynamics of plant pigments was studied on resistant cv. WR315 and susceptible cv. JG 62 under Phytotron growing conditions during 2019-2021. Result: Isolate ITCC 7681 was recorded to produce the lowest quantity of FA (126.88±5.56 mg L-1); whereas isolate ITCC 7682 produced the highest quantity of FA (820.51±13.37 mgL-1). Isolates ITCC 7682 and ITCC 7680 were recorded to be highly virulent initiating wilt symptoms within 19-24 hours of inoculation in chickpea seedlings of susceptible cv. JG 62. Culture filtrates of ITCC 7682 and ITCC 7681 caused a reduction of chlorophyll a (15.13-72.38% and 9.24-72.38%), chlorophyll b (16.28-89.83% and 13.95-97.74%), total chlorophyll (48.68-73.17% and 38.87-70.33%) and carotenoid (58.33-88.23% and 48.14-82.56%) contents 3 and 6 days after inoculation respectively. Reduction of all these pigments was significantly higher in susceptible cv. JG 62 than resistant cv. WR 315.
Mixed Messages in Women, Infants, and Children Lactation Support
Authors: Bianca Kelsey P.
Published: February 2023

Objective:

Breastfeeding provides health benefits, but women enrolled in the Special Supplemental Nutrition Program for Women, Infants, and Children (WIC) are less likely to breastfeed than those not enrolled. This study aimed to investigate the forms of messaging that occur in WIC lactation support.

Methods:

Ethnographic methods were used over a 3-month period in 2021. Observations were collected at WIC lactation care counseling sessions and were complemented with interviews, observations of other interactions, and archival documents.

Results:

The findings of this study indicate women received mixed messages about breastfeeding, including the advice, personal experience, and policies discussed in lactation counseling.

Conclusions:

This study suggests women’s personal experiences may conflict with the messages they receive from lactation support. Recommendations for lactation support programs and training are discussed.
Remdesivir and Breastfeeding—A Case Report
Authors: Morze Karolina
Published: February 2023

Objective:

The article presents a lactating patient who contacted the pharmacy office to inquire about the safety of coronavirus disease 2019 (COVID-19) therapy. She was given remdesivir, dexamethasone, and ceftriaxone during the 5-day hospital stay.

Main Issue:

The patient was worried about maintaining her milk supply during her hospital stay and the safety of the medication she received. At the hospital, she was given no information on when she could resume breastfeeding after discharge.

Management:

The pharmacist conducted an interview, determined the patient’s needs, assessed the safety of the drugs administered during the hospital stay in lactation, provided information to the patient, and stayed in touch with her during the hospital stay. As a result of the consultation, the patient decided to resume breastfeeding her baby 3 hours after discharge (or as soon as possible). The treatment did not impact the milk supply or affect the breastfed baby during a 6-day observation period. Follow-up focused on the mother’s health, potential adverse events in the baby, and the overall impact of COVID-19 infection and hospitalization on breastfeeding in this dyad.

Conclusion:

COVID-19 treatment with remdesivir, a low dose of dexamethasone, and ceftriaxone might be considered in lactating individuals without breastfeeding cessation or any other intervention apart from close observation of the infant. A change in the color of the milk might be concerning, but it is not a contraindication for breastfeeding. The effect of the maternal therapy, in this case, caused no apparent adverse reactions in the baby and did not impact the milk supply. The situation did not affect the mother’s ability to breastfeed.
PENGGUNAAN MEDIA PEMBELAJARAN UNTUK MENINGKATKAN HASIL BELAJAR SISWA PADA TINGKAT SD
Authors: Agustira Shinta , Rahmi Rina
Published: February 2023

ABSTRAK

Media pembelajaran merupakan  suatu alat bantu yang dapat digunakan oleh guru dalam proses belajar untuk menciptakan pembelajaran yang menarik dan lebih mudah di mengerti yang sesuai dengan tujuan pembelajaran, ada banyak sekali media pembelajaran yang bisa di gunakan baik dari lingkungan maupun dari buatan pabrik. Artikel ini bertujuan untuk mengkaji penggunaan media pembelajaran yang sesuai  untuk meningkatkan hasil belajar siswa di tingkat sekolah dasar (SD). Adapun jenis penelitian yang Digunakan dalam penelitian ini adalah penelitian kualitatif metode kajian literatur review. Teknik pengumpulan data menggunakan teknik dokumentasi yang di peroleh dari berbagai sumber yang meliputi artikel ilmiah, buku dan sebagainya yang di anggap relevan dengan penelitian ini, yang kemudian di analisis menggunakan teknik content Analysis. Hasil penelitian menunjukkan bahwa hasil belajar siswa di pengaruhi oleh penggunaan media dalam pembelajaran, ada banyak sekali manfaat dalam penggunaan media pembelajaran yaitu pembelajaran akan lebih menarik, materi yang di ajarkan lebih mudah di pahami oleh siswa.

Kata kunci : Media pembelajaran, Hasil belajar
Investigation of the Attitudes to Contemporary Art of the Students Continuing their Education in the Field of Art Education
Authors: MOLLAOĞLU Songül
Published: February 2023

Attitude is considered as an element in art because it is directly related to the feelings and perceptions of individuals. The aim of this study is to examine the relationship between the attitudes of students who continue their education in the field of art education towards contemporary art and their personal and educational characteristics. There are 515 students in the study conducted with the general screening model. The data of the research were obtained with the Student Information Form and the Contemporary Art Attitude Scale and analyzed in the SPSS program.

61.0% of the students with a mean age of 22.75 years (SD: 5.127) are female and 39.0% are male. 25.6% of the students continue their education in Radio, TV, Cinema, 24.9% in Art History, 12.2% in Painting, 12.4% in Architecture, 13.6% in Music and 11.3% in Graphics Department. 26.8% of them are in the fourth class, 24.7% in the third class, 22.9% in the second class and 25.6% in the first class, and the majority of them (78.8%) live in the city, 11.7% in the district. It has been observed that students' attitudes towards contemporary art are at a moderate level. It was determined that female students' attitudes towards contemporary art were more positive than male students, and students residing in the city were more positive than students residing in villages (p
Artificial intelligence in plastic surgery: current developments and future perspectives
Authors: Qin Feng , Gu Jianying
Published: February 2023

Driven by the rapid development of big data, the amount of clinical data, including complex information, is expanding. Traditional data analysis methods cannot meet the need for mining data information, and artificial intelligence (AI) solves this problem. AI is increasingly being incorporated into modern medical practice. Algorithms provided by AI support advanced analysis and provide individualized aid to optimize medical decision-making. In plastic surgery, AI has made many breakthroughs in diagnosis, pre-operative surgical design, treatment decisions, and patient management. Plastic surgeons must recognize AI’s potential development and limitations. This review describes the current application of AI in plastic surgery and discusses the challenges and problems that need to be solved. This study aims to foster the application of this new AI technology in clinical practice.
Diagnosis and Prognosis of Oral Cancer using classification algorithm with Data Mining Techniques
Authors:   Assistant Professor, Department of Computer Science, K.C.S. Kasi Nadar College of Arts & Science, Chennai, Ms N.Anitha , Ms K.Jamberi ,   PhD Research Scholar, Dept.of. Comp. Science and Engineering, Alagappa university, Karaikudi.
Published: February 2023

Data mining is the process of researching data from different view points and condensing it into useful information. There are several types of algorithms in data mining such as Classification algorithms, Regression, Segmentation algorithms, association algorithms, sequence analysis algorithms, etc.,. The classification algorithm can be used to bifurcate the data set from the given data set and foretell one or more discrete variables, based on the other attributes in the dataset. Our method of creating new algorithm GA+ID3 easily identifies oral cancer data set from the given data set. The genetic based ID3 classification algorithm diagnosis and prognosis of oral cancer data set is identified by this paper.
Identification of Neotropical Culex Mosquitoes by MALDI-TOF MS Profiling
Authors: Costa Monique Melo , Guidez Amandine , Briolant Sébastien , Talaga Stanislas , Issaly Jean , Naroua Halima , Carinci Romuald , Gaborit Pascal , Lavergne Anne , Dusfour Isabelle , Duchemin Jean-Bernard , Almeras Lionel
Published: February 2023

French Guiana mosquito fauna diversity encompasses 242 species, of which nearly half of them belong to Culex (Diptera: Culicidae) genus. Whereas several species from Culex genus are important vectors of arbovirus, scarce studies focus on Culex genus, notably due to the inaccurate morphological identification of field-caught females gender. Matrix-assisted laser desorption/ionization time-of-flight mass spectrometry (MALDI-TOF MS) has been reported as a promising method for the identification of mosquitoes. Culex females from French Guiana field were dissected based on morphological classification. Abdomens were used for molecular identification using COI (cytochrome oxydase 1) gene. Legs and thorax of 169 specimens belonging to 13 Culex species,( i.e. Cx. declarator, Cx. nigripalpus, Cx. quinquefasciatus, Cx. usquatus, Cx. adamesi, Cx. dunni, Cx. eastor, Cx. idottus, Cx. pedroi, Cx. phlogistus, Cx. portesi, Cx. rabanicolus and Cx. spissipes) were then submitted to MALDI-TOF MS analysis. A high intra-species reproducibility and inter-species specificity of MS spectra for each mosquito body part tested were noticed. A corroboration of the specimen identification was revealed between MALDI-TOF MS, morphological and molecular results. MALDI-TOF MS protein profiling proves to be a suitable tool for identification of neotropical Culex species and will permit to enhance knowledge on this highly diverse Culex mosquitoes genus.
A Potential Entomological and Epidemiological Drivers for Reemergence of Human African Trypanosomiasis in Ethiopia after 55 Years
Authors: Waldetensai Abate , Abose Ebise , Getachew Abebe , Tadesse Henok , Meharenet Behabilom , Hidoto Moges , Defabachew Hailemariam , Eukubay Araya , Kassahun Alemayehu , Gonfa Geremew , Wakgari Tesfa , Manaye Nigus , Hailemichael Tsegalem , Kore Kokeb , Asfaw Netsanet , Hassen Jemal , Mengesha Wondu , Tsega Daniel , Abera Adugna , Bokecho Belachew , Lemango Fiseha , Melese Tariku , Mulugeta Yimer , Wossen Mesfin , Regassa Feyisa , Tasew Geremew , Ali Abraham
Published: February 2023

Background: Sleeping Sickness, Human African Trypanosomiasis (HAT) is a vector- borne disease caused by Trypanosoma brucei (T.b). Sleeping sickness in Ethiopia was reported in 1967 for the first time. Recently in Southern parts of Ethiopia, in August 2022, five (5) cases of sleeping sickness (T. b. rhodesiense) were confirmed. Following this outbreak, the current investigation was aimed to identify the entomological and epidemiological drivers for the reemergence of HAT outbreak and recommend appropriate interventions.Methods: A cross sectional study design with descriptive data analysis was used. Tsetse fly collection and blood samples from cattle Animal were taken. NGU and bio-conical traps were used to determine the distribution (density and abundance) of the vector. About 10μl of blood was collected from the marginal ear vein of 301 cattle animals using the heparinized microhematocrit capillary. The parasite detection was carried out through vector dissection under binocular stereo-microscope (magnification of 60X) and microscopic examination from serum of Animals using the Buffy coat method. Results: A total of 329 tsetse flies were captured and identified to Glosina (G.) palidipes 259 (60.4%) and Glossina fuscipes 70 (16.3%). 188 (51.1%) of tsetse flies were collected from Dembagofa with 94 apparent density. Among all captured Tsetse fly, 39 (11.8%) of Tsetse were fed with high female apparent density in eachecological variation: wood land (51), Bush land (20) and grass land (11). Overall, the apparent density of tsetse fly was high in Wood land (93): G. pallidipes (76.5) and Bush land (36.5). Among all examine cattles for the presence of parasite, 9 cattles were detected positive with an overall prevalence of 3%. T. congolense 6 (2%) and T. vivax 1 (0.3%) with 2 (0.7%) suspected brucei. The parasite prevalence Trypanosoma was 4 (4.6%) in poor body a condition (Bcs) cattle. The animals in age range 5 - 9 years were infected high with 7 (5.3%) prevalence. Conclusion: The current study revealed that there are high-risk factors that predispose the community to Human African Trypanosomiasis (HAT) due to the presence of two different species of Tsetse flies and many animal reservoirs. The transmissions of Human African trypanosomiasis (HAT) are related to environmental, Vector, and human factors. Further geographically expanded investigation should be conducted throughout the country.
Mengungkap Perbedaan Identitas Sains Siswa di Indonesia Berdasarkan Gender
Authors: Hidayat Toni
Published: February 2023

Identitas sains siswa Indonesia sepertinya belum banyak diungkap. Sementara itu, identitas sains merupakan salah satu faktor yang mempengaruhi karir siswa di masa depan dalam bidang sains. Penelitian ini bertujuan untuk mengetahui level identitas sains siswa di Indonesia. Penelitian ini dilakukan pada siswa sekolah menengah di Tangerang Selatan dengan menggunakan metode survey dan convenience sampling. Angket identitas sains diisi oleh siswa sekolah menengah tersebut. Skor angket dikonversi ke dalam persentase yang kemudian dianalisis secara deskriptif dan inferensial. Hasil penelitian ini menunjukkan bahwa level identitas sains siswa laki-laki lebih tinggi dari pada perempuan. Lebih lanjut, identitas sains siswa pada komponen perasaan senang pada sains dan efikasi diri berbeda secara signifikan antara siswa laki-laki dan perempuan. Pengembangan identitas sains perlu dilakukan, terutama bagi siswa perempuan.
Pengembangan Media Pembelajaran Kimia Minyak Bumi Berbasis Green Chemistry Berbantuan Articulate Storyline
Authors: Qonita Nurul Atsna , Sari Wiwik Kartika , Mardhiya Julia
Published: February 2023

Pembelajaran dengan media konvensional menyebabkan siswa cenderung bosan dan menjadi penyebab kurangnya minat, motivasi, dan berpikir kritis. Era digital menuntut calon guru untuk berinovasi dalam mengembangkan media pembelajaran yang efektif dan efisien. Penelitian ini bertujuan mengembangkan media pembelajaran berbantuan articulate storyline berbasis green chemistry pada materi minyak bumi. Penelitian ini menggunakan metode Research and Development (R&D) dengan model pengembangan 4D (define, design, develop and disseminate). Penelitian ini dibatasi sampai tahap development. Kajian penelitian ini untuk mengetahui kelayakan dan respon siswa terhadap media pembelajaran kimia minyak bumi berbasis green chemistry berbantuan articulate storyline. Hasil validasi produk dilakukan oleh para ahli dengan menggunakan analisis data Aiken’s V. Hasil validitas memperoleh nilai sebesar 0,82 dengan kategori sangat tinggi. Adapun hasil uji coba skala kecil mendapatkan respon yang baik dari siswa dengan persentase rata-rata 71%.
Plasma D-Dimer Is Noninferior to Serum C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection
Authors: Tarabichi Saad , Goh Graham S. , Baker Colin M. , Chisari Emanuele , Shahi Alisina , Parvizi Javad
Published: February 2023

Background:

No single test has demonstrated absolute accuracy in the diagnosis of periprosthetic joint infection (PJI). Serological markers are often used as screening tools in the workup of patients with suspected PJI. This study aimed to determine the diagnostic utility of plasma D-dimer for PJI in a variety of clinical scenarios.

Methods:

This prospective study enrolled 502 patients undergoing revision hip or knee arthroplasty. PJI was defined per a modified version of the 2018 International Consensus Meeting (ICM) criteria. Plasma D-dimer, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and fibrinogen were measured preoperatively. Receiver operating characteristic curves were used to assess the utility of each biomarker in the diagnosis of PJI. Pairwise comparison with Bonferroni correction was performed to determine whether the differences in areas under the curve (AUCs) between the markers were significant.

Results:

Of the 412 patients included, 317 (76.9%) did not have an infection (aseptic group) and 95 (23.1%) had an infection (PJI group). All 4 serological markers, D-dimer (AUC, 0.860; sensitivity, 81.3%; specificity, 81.7%), CRP (AUC, 0.862; sensitivity, 90.4%; specificity, 70.0%), ESR (AUC, 0.833; sensitivity, 73.9%; specificity, 85.2%), and fibrinogen (AUC, 0.798; sensitivity, 74.7%; specificity, 75.4%), demonstrated comparable accuracy for the diagnosis of PJI (all p > 0.05). When examining the performance of the different inflammatory markers in diagnosing infection caused by indolent organisms, D-dimer demonstrated the highest sensitivity at 93.8%.

Conclusions:

We found that plasma D-dimer was noninferior to serum CRP and ESR in the diagnosis of PJI and may be a useful adjunct when screening patients undergoing revision total joint arthroplasty.

Level of Evidence:

Diagnostic Level II. See Instructions for Authors for a complete description of levels of evidence.
Best Practices for Planning and Implementing Site Investigations at Federally Owned or Regulated Dams and Levees
Authors: Bensko Kathleen , K. Simpson Bryan , Terry Thomas A. , Walker Scott R.
Published: February 2023

Management, regulation, and review of the planning and execution of intrusive site investigations vary within each of four federal organizations involved with dam and levee safety based upon various roles and responsibilities. The U.S. Bureau of Reclamation (USBR), the Tennessee Valley Authority, and the U.S. Army Corps of Engineers (USACE) are owner-operators of dams that serve multiple purposes, including flood control, hydropower, water supply, and navigation. The Federal Energy Regulatory Commission (FERC) regulates and inspects non-federal hydropower dams, and develops and implements policies, programs, and standards to ensure the safety of these licensed projects. Each organization (except FERC) is also responsible for oversight, rehabilitation, and repair of structures including damaged levees, canals, and dams, including some (in the case of USBR and USACE) that are operated and maintained by others. This paper provides a brief overview of the various regulations and guidance related to the planning and execution of intrusive site investigations conducted at structures within each organization's portfolio. It also provides a programmatic overview of the processes utilized by the different federal organizations for planning, reviewing, and implementing intrusive investigations. It covers specific requirements (guidance and regulations), time frames that are involved with the review process, and discusses updates and changes that are planned or being considered.
Cryogenian A-type Granites of the Yenisei Ridge – Indicators of Tectonic Transformation in the Southwestern Margin of the Siberian Craton
Authors: Vernikovskaya A.E. , Vernikovsky V.A. , Matushkin N.Yu. , Kadilnikov P.I. , Wingate M.T.D. , Bogdanov E.A. , Travin A.V.
Published: February 2023

—We document the evolution of A-type granitoid magmatism during the Cryogenian tectonic transformation of the Yenisei Ridge from a postcollisional mode to the early stage of development of an active continental margin. We illustrate the A-type granitoid magmatism evolution in a model for the emplacement and cooling of the intrusions of the Strelka pluton, reflecting the final stage of magmatism during the formation of the postcollisional Glushikha complex (719–702 Ma). These processes took place at the same time as the formation of mantle, mantle-crustal and crustal rocks of the Tatarka complex (711–683 Ma), including the Yagodka pluton A-type granites (711–705 Ma) during the early stage of active continental margin development. During this period of tectonic transition, both convergent events involved the continuous formation of felsic intrusions corresponding to oxidized A-type granites.
Geodemographic classification of the North Caucasus Federal District Regions
Authors:   North Caucasus Federal University, BADOV Alexander , BADOV Оleg ,   North Caucasus Federal University, DZAKHOVA Larisa ,   North Ossetian State University named after K. L. Khetagurov, BYAZROVA Juliet ,   North Ossetian State University named after K. L. Khetagurov
Published: February 2023

Introduction. The dynamics of the vital movement of the population of the North Caucasus for 2005-2020 is investigated. Research methods and materials. Both traditional and the latest geographic research methods are used - comparative geographical, spatial analysis, statistical, GIS technologies, population surveys, etc. Research results. The conducted studies have shown that despite the apparent well-being, a tense demographic situation is developing in the North Caucasus. Favorable demographic results are obtained only at the expense of three subjects - Dagestan, Ingushetia and Chechnya. In other regions, narrowed and negative reproduction is observed. The natural increase is getting lower and lower. The small generation born in the 1990s reached the fertile age. COVID-19 restrictions and a crisis in the economy have led to an even greater decline in the birth rate and an increase in mortality. The conducted geodemographic classification of the regions of the North Caucasus showed that the most favorable situation is observed in Ingushetia, the situation is slightly worse in Chechnya and Dagestan, narrowed reproduction in Kabardino-Balkaria and Karachay-Cherkessia and the most tense situation is in North Ossetia and the Stavropol Territory. Conclusion. To improve the situation, a differentiated approach is needed to different regions in the demographic sphere, the creation of new workplaces. The outflow of the able-bodied population from the regions of the North Caucasus leads to a violation of the population age composition and, thereby, undermines the fertility of the population. This leads to a decrease in the birth rate and, accordingly, natural increase. Resume. The article presents the results of studies of the natural movement of the population of Russia and the North Caucasus Federal District. At the same time, the multi-scale method of research and geodemographic classification was taken as the basis. It has been established that relatively favorable results on the scale of Russia were achieved in the North Caucasus Federal District, and on the scale of the North Caucasian Federal District - in Ingushetia, Chechnya and Dagestan. It was determined that along with the traditional factors of mortality, the factor of infectious morbidity began to play a significant role. It is shown that at the same time, mortality in working age has increased. It was revealed that there is a significant territorial differentiation of the natural movement of the population both in Russia as a whole and in the North Caucasus Federal District. The results of the research can be useful in developing programs for further demographic development of the regions.
Methodological bases for synthesis operation models for control of the reproduction process of the advancing faces of coal mines
Authors:   National University of Science and Technology “MISiS”, KUZNETSOV Yuri , STADNIK Denis ,   North Caucasian Institute of Mining and Metallurgy (State Technological University), STADNIK Nino ,   North Caucasian Institute of Mining and Metallurgy (State Technological University), SHADYZHEVA Eset ,   National University of Science and Technology “MISiS”
Published: February 2023

This article presents the results of optimizing the reliability and reliability of the time forecast’s development reserves of the coal mine long wall areas and the preparation time of the face longwall line. A scheme of the reproduction the long wall front process in the form of a decision tree model has been developed. The dependences of the optimal probability of the absence of coal mining losses and the optimal dynamic time reserve on the reliability of longwall and preparatory work and on the ratio of damage in case of shortage, as well as the costs of maintaining the cleaning front, are established. It is shown that when forming a mining development plan, the value of the optimal dynamic time reserve should be determined for each treatment face. It is determined that when providing dynamic redundancy of the process of reproduction of the longwall front, the possibilities of performing degassing and drainage of mineral reserves being prepared for extraction are more fully realized which positively affects the level of reliability and safety of longwall operations.
Role of Bioinformatics in Cancer Diagnosis
Authors: Valand Jainam H. , Twine Davis , Kyomukamaa Moreen , Atino Rebecca , Buteme Grace Manana , Muhahiria Samson , Nalwoga Racheal , Omary Iddy , Nabwami Anita Grace , Otim Emmanuel , Kabasa David , Luyima Adam
Published: February 2023

Cancer is one of the leading causes of mortality around the world accounting for about 10 million deaths in 2020 according to the World Health Organization. The cancer types that claim the most lives around the world include breast cancer, lung cancer, stomach cancer, colon, and rectum cancer. There are a variety of risk factors that can lead to cancers ranging from the type of diet to the type of virus infection. The number of lives claimed by cancer every year can however be reduced through early detection of cancer during which there is a very high chance that the cancer can be cured if appropriate treatment is provided.
Today, due to the development of microarray technology, large amounts of data on differentially expressed genes can be obtained from cancerous cells. This vast amount of data, therefore, requires the use of computational tools and databases to store, process, and extract valuable information from the collected data for example discovering new biomarkers for cancer diagnosis. This, therefore, calls for the application of bioinformatics resources to perform this task. The review article, therefore, focuses on how the different bioinformatics tools and databases have been used to improve cancer diagnosis through a systematic literature search on PubMed. From the literature search, it was seen that bioinformatics tools and databases have been used to detect different diagnostic biomarkers that were associated with the different cancer types such as cervical cancer, ovarian cancer, pancreatic cancer, and lung cancer. The biomarkers detected thus help to improve early cancer detection and hence reduce cancer-related mortality.
From the literature studied, it was also seen that some of the biomarkers detected for one type of cancer were also common to other cancer types. Bioinformatics, therefore, plays a vital role in the improvement of cancer diagnosis by detecting biomarkers that can be used to diagnose cancer. Bioinformatics also helps in identifying common biomarkers and differentially expressed genes in different cancer types which further improves the process of cancer diagnosis.
Implications of the social determinants of health and identifying effective community-based interventions to prevent and control infectious diseases in urban informal settlements in low- and middle-income countries: a systematic review
Authors: Shafique Sohana , Bhattacharyya Dipika Shankar , Nowrin Iffat , Islam Rayhanul , Dutta Goutam Kumar , Sultana Foyjunnaher , Barrio Mariam Otmani del , Reidpath Daniel D
Published: February 2023

Background
The impact of rapid urbanization taking place across the world is posing variegated challenge. Especially in terms of communicable disease, the risk is more concentrated in urban poor areas where basic amenities are inadequate. In this context, the aim of this study was to carry out an evidence synthesis on the state-of the art effective community-based interventions in tackling infectious diseases among the urban poor in the LMICs across the globe.
Methods
This review has been registered in PROPSPERO (CRD42021278689). A total of 18,260 published articles were primarily selected; after applying the inclusion and exclusion criteria 115 studies were considered for full-text screening. Among them, 17 articles were included. Afterwards, reference check was done and finally total of 21 articles were considered for the systematic review. Narrative synthesis was done.
Results
The pathway to identifying and addressing the SDOH through community-based intervention in the urban poor setting was complex. For effectiveness of a community-based intervention, the socio-cultural context is found extremely important. From this review, the effective community-based interventions were- community-based screening and socio-economic support, community-based vector control, behaviour change communication, capacity building of the Community Health Workers, health education and e-health interventions. Interventions need to be delivered considering the day-to-day realities of the urban poor. While some studies considered the outcome of specific diseases through vertical intervention approach, scarcity of evidence was found in terms of taking an intersectional approach.
Discussion
The effectiveness of an intervention are inextricable linked with social context, stakeholder dimensions and macro level social issues. The review results thus suggestive of an intervention package that considers a systems approach.
Conclusion
Considering this complex reality of an intervention to be effective, this evidence-synthesis therefore advocates for designing the intervention package with multiple components related to prevention and control of communicable diseases in poor urban areas.
PROSPERO registration number:
This review has been registered in PROPSPERO (CRD42021278689).
A Microemulsion Superlubricant with Largely Switchable Friction
Authors: Chen Siwei , Sun Hong , Liu Jian , Wang Jinyu , Lu Hongsheng , Hao Jingcheng , Xu Lu , Liu Weimin
Published: February 2023

Superlubrication has been discovered in van der Waals 2D materials and dispersions of lipids, polymers and nanoparticles, but not in microemulsions consisting of oil, water and surfactants, although they have been extensively applied in industrial fields. Here, for the first time, we create a microemulsion displaying superlubricity in a broad temperature from -30 to 20 ºC using n-hexane, water, surfactant DDACe ((C12H25)2N+(CH3)2[CeCl4]-) and ethylene glycol as compositions. The microemulsion is capable of abruptly and dramatically switching its coefficient of friction by approximately 25 folds based on a thermoreversible microemulsion-emulsion transition, thus showing great potentials in smart devices and controllable transportation. Its anti-freezing performance allows it to provide excellent lubrication even when the surrounding temperature attains as low as -60 ºC. Together with its facile preparation, high colloidal stability and magneto responsiveness, such novel smart microemulsion superlubricant is envisioned to find widespread applications in engineering, industry, materials science and tribology.
Assessment of urban form resilience: A review of literature in the context of the Global South
Authors: Shukla Nitesh , Das Arup , Mazumder Taraknath
Published: February 2023

Building resilient and sustainable cities in the face of rising climate change have captured the attention of the research community as well as decision-makers. Despite the sizable quantum of research on different aspects of urban resilience, the physical form of cities has received little attention from researchers. Another difficulty lies in generalizing these studies in varying settings and heterogeneous contexts. This study investigates different tools and frameworks proposed for assessing urban form resilience. The literature analysis has been done based on attribute selection, study context, methodology, and resilience perspective. Additionally, the applicability of these frameworks in the context of the Global South has been investigated. The result shows fragmentation in the selection of attributes, approaches, and perspectives in the literature assessing urban form resilience. Also, there are conflicting arguments regarding the influence of urban form attributes on urban resilience, i.e., density and city size. Apart from that, the study highlights the complications of imbibing these assessment frameworks in the distinct urban morphology of cities of the Global South, where informal development prevails. This study can help researchers and planners understand the relationship between resilience and urban morphology and utilize these concepts for assessing urban form resilience, particularly in the context of the Global South.
Functional and developmental changes in the inner hair cell ribbon synapses caused by Myosin VI knockout and deafness-inducing point mutation
Authors: Li Geng-Lin , Yin Ning , Zhao Jingjing , Zhang Panpan , Yu Baofu , Chai Renjie
Published: February 2023

Hearing loss is one of the most common neurosensory disorders in humans, and above half of hearing loss is caused by gene mutations. Among more than 100 genes that cause non-syndromic hearing loss, myosin VI (MYO6) is typical in terms of the complexity of underlying mechanisms, which are not well understood. In this study, we used both knock-out (Myo6-/-) and point mutation (Myo6C442Y) mice as animal models, performed whole-cell patch-clamp recording and capacitance measurement in the inner hair cells (IHCs) in the cochlea, and sought to reveal potential functional and developmental changes in their ribbon synapses. In Myo6-/- cochleae of both before (P8-10) and after hearing onset (P18-20), exocytosis from IHCs, measured in whole-cell capacitance change (ΔCm), was significantly reduced, Ca2+ current amplitude (ICa) was unchanged, but Ca2+ voltage dependency was differently altered, causing significant increase in Ca2+ influx in mature IHCs but not in immature IHCs. In immature IHCs of Myo6C442Y/C442Y cochleae, neither ΔCm nor ICa was altered, but both were reduced in mature IHCs of the same animal model. Furthermore, while the reduction of exocytosis was caused by a combination of slower rate of depleting readily releasable (RRP) pool of synaptic vesicles and slower sustained release rate (SRR) in Myo6-/- immature IHCs, it was likely due to smaller RRP and slower SRR in mature IHCs of both animal models. These results expand our understanding of the mechanisms of deafness caused by MYO6 mutations, and provide a solid theoretical and scientific basis for the diagnosis and treatment of deafness.
Nicotinamide enhances osteoblast differentiation through the activation of mitochondrial antioxidant defense system
Authors: Ryoo Hyun-Mo , Yoon Heein , Park Seung Gwa , Kim Hyun-Jung , Shin Hye-Lim , Kim Woo-Jin , Kim Ki-Tae , Cho Young-Dan , Moon Jae-I , Park Min-Sang
Published: February 2023

Though the normal physiological level of oxidative stress is beneficial for maintaining bone homeostasis, however, the imbalance between reactive oxygen species (ROS) production and antioxidant defense can cause various bone diseases. The purpose of this study was to see whether nicotinamide (NAM), an NAD+ precursor, could support the maintenance of bone homeostasis via regulating osteoblasts. Here, we demonstrate that NAM enhanced osteoblast differentiation and mitochondrial metabolism. NAM increased the expression of antioxidant enzymes, which was due to increased FOXO3a transcriptional activity via SIRT3 activation. NAM has not only a preventive effect to a weak and chronic oxidative stress but also a therapeutic effect to a strong and acute exposure to H2O2 in osteoblasts differentiation. Collectively, NAM increased mitochondrial biogenesis and antioxidant enzyme expression through the activation of SIRT3-FOXO3a axis that consequently enhanced osteoblast differentiation. These results suggest NAM could be a potential preventive or therapeutic agent for the bone diseases caused by ROS.
Unexpected Impairment of INa current Underpins Reentrant Arrhythmias in a Knock-in Swine Model of Timothy Syndrome
Authors: Porta-Sanchez Andreu , Mazzanti Andrea , Tarifa-Lora Carmen , Kukavica Deni , Trancuccio Alessandro , Mohsin Muhammad , Zanfrini Elisa , Perota Andrea , Duchi Roberto , Hernandez-Lopez Kevin , Fernandez-Moya Eugenio , Bongianino Rossana , Tavazzani Elisa , Scacchi Simone , Pavarino Luca , Franzone Piero Colli , Lentini Giovanni , Filgueiras-Rama David , Galli Cesare , Santiago Demetrio , Priori Silvia
Published: February 2023

Timothy Syndrome 1 (TS1) is a multiorgan form of Long QT Syndrome associated with life-threatening cardiac arrhythmias, the organ-level dynamics of which remain unclear. Here, we developed and characterized a novel porcine model of TS1 carrying the causative p.Gly406Arg mutation in CACNA1C, known to impair CaV1.2 channel inactivation. Our model fully recapitulated the human disease with prolonged QT interval and arrhythmic mortality. Electroanatomical mapping revealed the presence of a functional substrate vulnerable to reentry, stemming from an unforeseen constitutional slowing of cardiac activation. This signature substrate of TS1 was reliably identified using reentry vulnerability index, which we further demonstrate can be used as a benchmark for predicting treatment efficacy, as shown by pharmacological shortening of action potential using HERG channel agonist ICA-105574. Notably, in vitro experiments showed that TS1 cardiomyocytes display Ca2+ overload and decreased peak INa current, providing a rationale for the arrhythmogenic slowing of impulse propagation in vivo.