bluuebunny/crossref_metadata_2025 huggingface dataset:
PSYCHOLOGY OF CHILDREN’S PLAY AND STEM-EDUCATION IN THE DEVELOPMENT OF COGNITION, EMOTION, IMAGINATION, AND CREATIVITY IN CHILDHOOD
Authors: Shishova Evgeniya
Published: November 2023

This study explores the issues related to the role of children’s
play in the development of cognition, emotion, imagination, and creativity. It
increases the effectiveness of preschoolers’ educational activities by improving
their educational environments in order to ensure each child’s creativity
and support children’s initiatives, allowing them to be independent and
active. Modern experts emphasize the need to support children’s cognitive
initiatives in the context of preschool education and family (Veraksa, ).
Preparing children for the twenty-fi rst century challenges begins in the early
years when they are naturally curious and excited learners, constantly asking
questions. The STEM approach in education will make it possible to personalize
educational trajectories, to take into account personality characteristics
and enable the learners’ creative potential to unfold, laying the foundation
for the digital transformation of their education. These activities promote
creativity as children question, explore, investigate, and construct meaning
through problem-solving and applying previous experiences. All these important
skills are employed in the STEM learning paradigm which includes
most academic subjects and promotes the development of twenty-fi rst century
skills. The study is based on the theoretical foundations of sociocultural
studies devoted to the role of children’s play in the development of cognition,
emotion, imagination, and creativity in playworlds and educational environments
(Vygotsky, ; Elkonin, ; Leontiev, ; Bronfenbrenner, ;
Nilsson, Ferholt & Lecusay, ; Smirnova, , ). It presents the ANOVA
results and correlation analysis, stating that the quality of preschooler’s
education (ECERS-R measurement issue results in Russia) depends on certain
indicators of teachers’ professional skills and affects the development of
the child’s play activity. The data obtained can serve as reference points for
transformation of the preschool education system.
TRANSITION TO SECONDARY EDUCATION: RE-THINKING THE BACKGROUND OF THE PLACE-VALUE COUNTING
Authors: Vysotskaya Elena , Lobanova Anastasia , Yanishevskaya Maria
Published: November 2023

The diffi cult period of transition between primary and secondary
school demands deep “re-thinking” of the content of school curricula, mathematics
in particular. In order for the principles of place-value computations (our
current study subject), not only to conclude the elementary school, but also to
make a solid foundation for students’ further promotion. The mistakes students
make, while using the “well-learned” decimal system, stem from their miscomprehension
of the structure and the arrangement of “positional” counting. Thus,
following Davydov, we suggest reconstructing the place-value origin by organising
and scaffolding students’ own learning actions in other-base counting systems.
Our research goal is to discover and describe the psychological conditions
for students’ acquisition and appropriate application of the place-value concept
in various critical computational tasks. For this purpose, we have devised a wide
range of task conditions, which were modifi ed according to the principles suggested
by Galperin, in order to keep the orientation procedure in demand and
thus achieve the desired consciousness in thinking. These tasks were embedded
into the “intergalactic” storyline, so that students would join the “cosmic voyagers”
on their expedition, as they have to calculate the exact amounts of “cosmo-fuel”
for different-base counting systems. We have conducted several cycles of experimental
teaching (about  hours each) according to the materials and instruction,
which we have designed: a total of  students (- years of age, th-th grade)
comprised our sample. In our investigation we followed the “planned formation”
method of Galperin and the traditions of the developmental instruction design
(according to El’konin and Davydov). The results of the teaching series proved
the potential of the content and the computer support, which we have developed,
for the promotion of mathematical literacy and for overcoming the formalism of
calculation procedures, adopted in primary school.
CURRENT DIRECTIONS IN THE DIGITAL TRANSFORMATION OF EDUCATION: PROSPECTS AND NEW OPPORTUNITIES FOR THE DEVELOPMENT OF TRADITIONAL EDUCATION
Authors: Yamaleeva Fanzilla
Published: November 2023

The development of the direction of digital transformation in
education opens up prospects and new opportunities for the development
of traditional education, designed to provide assistance, scientifi c and methodological
support to subjects of education when introducing various kinds
of innovations. The article shows the features of regional methodological
services, the main problems and prospects of development in digital transformation
in education. Methodological foundations of the research were
the general scientifi c approaches: systemic, socio-logical, activity–based and
modern methodologies of ecosystem, cluster, metacompetence approaches.
Methodological principles that defi ne the requirements for methodological
support of teachers, for work with children in the world of digitalization,
such as systematic measures to support all subjects of education; orientation
to the result, voluntariness, and accessibility are highlighted. The leading
principles are openness and targeting, as they make it possible to attract
leaders.
Peran Guru Akidah Akhlak Dalam Membentuk Akhlakul Karimah Pada Peserta Didik Kelas V Di MI Muhammadiyah 3 Al Furqan Banjarmasin
Authors: Fauniah Emma , Kumala Sari , Arifin M. Fahmi
Published: November 2023

Penelitian ini bertujuan untuk mendeskripsikan peran guru akidah akhlak dalam membentuk akhlakul karimah pada peserta didik kelas V di MI Muhammadiyah 3 Al Furqan Banjarmasin serta mendeskripsikan faktor pendukung dan penghambat peran guru dalam membentuk akhlakul karimah pada peserta didik melalui pembelajaran akidah akhlak kelas V di MI Muhammadiyah 3 Al Furqan Banjarmasin. Penelitian ini menggunakan pendekatan kualitatif dengan jenis penelitian deskriptif. Pengumpulan data dilaksanakan melalui observasi, wawancara, dan dokumentasi. Teknis analisis adalah reduksi data, penyajian data, penarikan kesimpulan. Peneliti menggunakan triangulasi teknik dan triangulasi sumber untuk memperoleh keabsahan data. Berdasarkan hasil penelitian dapat disimpulkan bahwa peran guru dalam membentuk akhlakul karimah pada peserta didik melalui pembelajaran akidah akhlak kelas V di MI Muhammadiyah 3 Al Furqan Banjarmasin dilakukan dengan: 1). Guru sebagai Pendidik, 2). Guru sebagai Pembimbing, 3). Guru sebagai Latihan Pembiasaan Nasehat atau Motivasi. Faktor pendukung peran guru dalam membentuk akhlakul karimah pada peserta didik melalui pembelajaran akidah akhlak kelas V di MI Muhammadiyah 3 Al Furqan Banjarmasin yaitu: 1) Adanya kesadaran siswa, 2) Keluarga, 3) Lingkungan, 4) Motivasi Guru, 5) Teladan. Adapun Faktor penghambatnya yaitu: 1) Keluarga, 2) Lingkungan, 3) Gadget.
Program Karantina Ramadhan: Optimalisasi Hafalan Al-Qur'an pada Santriwati Asrama Tahfidz Putri Darul Furqan Wal Ilmi Amuntai
Authors: Azkia Soviatul , Salamah Umi , Nasir Muhammad
Published: November 2023

Tujuan dari penelitian ini adalah untuk memberikan gambaran mengenai pelaksanaan Karantina Tahfidz Al-Qur'an selama 20 hari di Asrama Tahfidz Putri Darul Furqan Wal Ilmi Amuntai, termasuk pencapaian hafalan para santriwati serta rintangan yang dihadapi oleh penyelenggara dan peserta karantina. Metode yang digunakan dalam penelitian ini ialah secara kualitatif deskriptif. Dari hasil penelitian, diketahui bahwa pelaksanaan Karantina Tahfidz Al-Qur'an di Asrama Tahfidz Putri Darul Furqan Wal Ilmi Amuntai menggunakan beberapa program, seperti program inti dan pendamping, serta pelajaran tambahan selama 20 hari di bulan Ramadhan. Para santriwati usia SD/MI mampu menghafal rata-rata 1 juz, sementara peserta dewasa yang mengikuti karantina mampu menghafal sekitar 2-3 juz. Salah satu masalah yang dihadapi oleh penyelenggara adalah jadwal setoran yang berbenturan dengan jadwal mengajar, terutama di jam Subuh dan Dhuha, Peserta karantina setoran terlalu cepat dan ada yang terlalu lambat untuk setoran. Sementara itu, kendala yang dihadapi oleh peserta karantina adalah jadwal yang padat dan adanya ayat-ayat yang kompleks atau sulit untuk dihafal
Expansion of BPJS Ketenagakerjaan BPU Membership through Marketing Mix Strategy and Regulation
Authors: Rekson Silaban Badikenita
Published: November 2023

Implementation of the social security system in Indonesia has entered a new era, in line with the implementation of Law no. 40 of 2004 on Social Security System (Navigation) and Law No.24 of 2011 on Social Security Agency (BPJS), one of which is where the mandated implementation of the national social security system. This study aims to do a comparison of the Indonesian social security system and how the expansion of its participants with marketing mix strategy and regulation. Analysis was performed on workers not wage (BPU). The analysis was performed on the program, promotion, distribution, amosunt of dues, processes, actors, and physical evidences, regulation, and provision of an age limit of 56 years. The study shows that the application of the social security system by the method of marketing mix and regulation will have a broad effect on the expansion of membership. Their overall strategy and emphasis through the regulation will affect the expansion of the BPU coverage. The addition of the age limit for BPU will increase the number of participants.
SOCIAL CAPITAL, ITS PARADIGM AND REALIZATION OF DIGNITY OF HUMAN LABOR ACTIVITIES
Authors: Živković Aleksandar
Published: November 2023

The development of productive forces in the twentieth, and especially in the twenty-first century, takes place in the sign of the affirmation of knowledge, as a basic resource of the development of society and changes in its civilization that is taking on a new era in its evolutionary development. The importance of knowledge has grown thanks to changes in the content and character of human labor activities expressed in its intellectualization, which is realized primarily not in the engagement and spending of human muscle power, but in activation, manifestation and confirmation of his intellectual abilities. Changes in the content and character of human labor activity also require changes in the paradigms of its management at all levels of its manifestation, from concrete forms of organization to the global structure of society. Those changes, starting from changes in its content, should mark harmonization of requirements of its purposefully targeted activity with certain positive consequences of creatively profitable aspects and human characteristics as a thinking and valued being on the line of understanding, thinking and treating man in labor activities to a lesser extent as a being capable of expressing the demands of the executor of work orders, but more as a creative being. With such a development, the evolution of human society would mark its development in the direction of the realization of man as a creator, which is in accordance with the development of man as sui generis.
FISCAL IMPLICATIONS OF THE WORLD CRISIS CAUSED BY THE COVID 19 VIRUS PANDEMIC
Authors: Đurović Todorović Jadranka , Ristić Cakić Milica
Published: November 2023

The governments of all countries of the world have faced up with the health crisis caused by the Covid 19 virus pandemic in the previous and current year. This crisis turned into an economic crisis, considering that it was necessary to provide huge financial resources to overcome it. Governments "pumped" additional amounts of money by supplying the economy and the population with new liquidity through subsidies and one-time assistance in the form of "helicopter money". Тhis has contributed to the deterioration of the fiscal performance of the world economies. The paper analyzes the economic and fiscal performance of the world leading economies such as the European Union, the United States, China and Russia. The aim of this paper is to point out the consequences of the applied measures in the domain of monetary and fiscal policy and influence on the increase of the budget deficit and public debt in the world.
OCJENA FINANSIJSKE STABILNOSTI PREDUZEĆA U TRŽIŠNIM USLOVIMA POSLOVANJA POD UTICAJEM PANDEMIJE KOVIDA-19 U REPUBLICI SRPSKOJ
Authors: Starčević Vitomir , Stevanović Suzana
Published: November 2023

Transformisanje privrednog sistema prema standardima tržišno razvijenih zemalja i provođenje dugotrajne privatizacije uslovili su preduzeća u Republici Srpskoj da u novonastalom tržišnom okruženju iznalaze mogućnosti za očuvanje svoje finansijske stabilnosti. Poznato je da oduvijek turbulentna tržišta prednost daju onim preduzećima koja mogu obezbijediti dobru finansijsku stabilnost i koja se brzo prilagođavaju turbulentnim tržišnim promjenama. Zato, preduzeća Republike Srpske svih ovih godina se prilagođavaju tržišnom načinu poslovanja kako bi u nelojalnoj konkurenciji pokušala izgraditi finansijsku stabilnost koja bi im obezbijedila određenu reputaciju na turbulentnim tržištima. Uz borbu prilagođavanja tržišnom načinu poslovanja u posljednjoj godini poslovanja pod uticajem pandemije kovida-19 preduzeća u Republici Srpskoj prolaze kroz razne neočekivane izazove koje treba da savladaju kako bi obezbijedila finansijsku stabilnost. Iz konteksta rečenog, istraživanje u radu je usmjereno na ocjenu finansijske stabilnosti preduzeća u tržišnim uslovima poslovanja pod uticajem pandemije kovida-19. S tim u vezi, značaj u istraživanju se pridaje ocjeni finansijske stabilnosti na primjeru konkretnog preduzeća u tržišnim uslovima poslovanja pod uticajem pandemije kovida-19 koristeći se osnovnim analitičkim pokazateljima koji se koriste kod ocjene finansijske stabilnosti preduzeća.
UPRAVLJANJE ODRŽIVIM RAZVOJEM ZEMALJA ZAPADNOG BALKANA U USLOVIMA PANDEMIJE KOVIDA-19
Authors: Vujović Tanja
Published: November 2023

Slobodan protok roba, usluga, ljudi i kapitala, razvoj informacione i komunikacione tehnologije, učinili su da lokalni problemi postanu globalni. Finansijska kriza 2007. godine vrlo brzo je postala globalna. Pandemija kovida-19 izazvala je svetsku zdravstvenu krizu, koja je ubrzo prerasla u ekonomsku, uz pretnju da postane i društvena kriza. Makroekonomski troškovi pandemije ogledaju se u padu bruto domaćeg proizvoda (GDP), rastu nezaposlenosti, povećanju fiskalne i eksterne neravnoteže. Fiskalna politika je u svim zemljama bila okosnica ekonomske politike u borbi protiv posledica pandemije. Ono što se sa sigurnošću može reći je da je šok pandemije pogodio ekonomiju i sa strane agregatne tražnje i sa strane agregatne ponude. U radu pokušavamo da sagledamo kako je pandemija delovala na privrede zemalja Zapadnog Balkana, sa kolikim privrednim padom su se suočile u 2020. godini. U radu takođe analiziramo koliko su javni sektor, zdravstvo i obrazovanje bili efikasni u borbi protiv posledica pandemije.
РАЗВОЈ МЕТОДОЛОГИЈЕ ЗА ПРОЦЕНУ НАУЧНИХ И ТЕХНОЛОШКИХ РИЗИКА ТЕХНОЛОШКЕ ИНТЕГРАЦИЈЕ
Authors: Davydov Alexey
Published: November 2023

Циљ студије је да се развије методички алат за процену научних и технолошких ризика од технолошке интеграције прерађивачких предузећа. За основне методе истраживања одабране су кључне одредбе теорије управљања, теорије организације и савремених теорија ризика. Методолошки оквир су били инструментални, процесни, ресурсни и матрични приступи. У процесу истраживања примењен је широк спектар истраживачких метода: дескриптивна метода, метода генерализације и апстракције, метода класификације и аргументације, те аналитичкa и графичка метода. Теоријски резултати студије су откривање кључних критеријума које техника за процену научних и технолошких ризика учесника у технолошкој интеграцији мора испунити. Дата је теоријска основа за класификационе особине научних и технолошких ризика, омогућавајући идентификацију предности квантификације ризичне ситуације. Примењени резултати студије су аналитичка процена научних и технолошких ризика технолошке интеграције производних предузећа заснованих на квантитативним методама. Предложена је метода за процену научних и технолошких ризика, која ће се градити на анализи ризичних догађаја, како би се идентификовала могућа величина штете од почетка ових ризичних догађаја и вероватноћа да ће се они појавити. Оправдане су предности предложене технике квантификације научних и технолошких ризика повезаних са могућношћу регулације класификације ризика, која је на располагању учесницима технолошке интеграције. Проведена класификација фактора ризика науке и технологије омогућава проширење спектра анализираних ризика за учеснике технолошке интеграције, као и примјену оперативног праћења како би се идентификовале нове области ризика.
Rab7-dependent regulation of goblet cell protein CLCA1 modulates gastrointestinal homeostasis
Authors: Gaur Preksha , Rajendran Yesheswini , Srivastava Bhagyashree , Markandey Manasvini , Fishbain-Yoskovitz Vered , Mohapatra Gayatree , Suhail Aamir , Chaudhary Shikha , Tyagi Shaifali , Yadav Subhash Chandra , Pandey Amit Kumar , Merbl Yifat , Bajaj Avinash , Ahuja Vineet , Srikanth Chittur
Published: November 2023

Inflammation in ulcerative colitis is typically restricted to the mucosal layer of distal gut. Disrupted mucus barrier, coupled with microbial dysbiosis, has been reported to occur prior to the onset of inflammation. Here, we show the involvement of vesicular trafficking protein Rab7 in regulating the colonic mucus system. We identified a lowered Rab7 expression in goblet cells of colon during human and murine colitis. In vivo Rab7 knocked down mice (Rab7KD) displayed a compromised mucus layer, increased microbial permeability, and depleted gut microbiota with enhanced susceptibility to dextran sodium-sulfate induced colitis. These abnormalities emerged owing to altered mucus composition, as revealed by mucus proteomics, with increased expression of mucin protease chloride channel accessory 1 (CLCA1). Mechanistically, Rab7 maintained optimal CLCA1 levels by controlling its lysosomal degradation, a process that was dysregulated during colitis. Overall, our work establishes a role for Rab7-dependent control of CLCA1 secretion required for maintaining mucosal homeostasis.
Similar excitability through different sodium channels and implications for the analgesic efficacy of selective drugs
Authors: Xie Yu-Feng , Yang Jane , Ratté Stéphanie , Prescott Steven A
Published: November 2023

Nociceptive sensory neurons convey pain-related signals to the CNS using action potentials. Loss-of-function mutations in the voltage-gated sodium channel NaV1.7 cause insensitivity to pain (presumably by reducing nociceptor excitability) but clinical trials seeking to treat pain by inhibiting NaV1.7 pharmacologically have struggled. This may reflect the variable contribution of NaV1.7 to nociceptor excitability. Contrary to claims that NaV1.7 is necessary for nociceptors to initiate action potentials, we show that nociceptors can achieve similar excitability using different combinations of NaV1.3, NaV1.7, and NaV1.8. Selectively blocking one of those NaV subtypes reduces nociceptor excitability only if the other subtypes are weakly expressed. For example, excitability relies on NaV1.8 in acutely dissociated nociceptors but responsibility shifts to NaV1.7 and NaV1.3 by the fourth day in culture. A similar shift in NaV dependence occurs in vivo after inflammation, impacting ability of the NaV1.7-selective inhibitor PF-05089771 to reduce pain in behavioral tests. Flexible use of different NaV subtypes exemplifies degeneracy – achieving similar function using different components – and compromises reliable modulation of nociceptor excitability by subtype-selective inhibitors. Identifying the dominant NaV subtype to predict drug efficacy is not trivial. Degeneracy at the cellular level must be considered when choosing drug targets at the molecular level.
The molecular basis of Abelson kinase regulation by its αI-helix
Authors: Paladini Johannes , Maier Annalena , Habazettl Judith Maria , Hertel Ines , Sonti Rajesh , Grzesiek Stephan
Published: November 2023

Abelson tyrosine kinase (Abl) is regulated by the arrangement of its regulatory core, consisting sequentially of the SH3, SH2, and kinase (KD) domains, where an assembled or disassembled core corresponds to low or high kinase activity, respectively. It was recently established that binding of type II ATP site inhibitors, such as imatinib, generates a force from the KD N-lobe onto the SH3 domain and in consequence disassembles the core. Here, we demonstrate that the C-terminal αI-helix exerts an additional force toward the SH2 domain, which correlates both with kinase activity and type II inhibitor-induced disassembly. The αI-helix mutation E528K, which is responsible for the ABL1 malformation syndrome, strongly activates Abl by breaking a salt bridge with the KD C-lobe and thereby increasing the force onto the SH2 domain. In contrast, the allosteric inhibitor asciminib strongly reduces Abl’s activity by fixating the αI-helix and reducing the force onto the SH2 domain. These observations are explained by a simple mechanical model of Abl activation involving forces from the KD N-lobe and the αI-helix onto the KD/SH2SH3 interface.
Availability of Raw Material for Wood Based Cricket Bat Industry in Kashmir Valley, India
Authors: Teeli Nawaz Ahmad , Raj Anup , Khan P. A. , Rafeeq Jauhar
Published: November 2023

Kashmir Himalayas is known for its abundant supply of high quality wood suitable for cricket bat industry. The present study aimed to gather comprehensive data on the availability of raw material for the cricket bat industry in Anantnag and Pulwama districts of Kashmir during the specified time period (2017-2018). The main objective of this study was to evaluate the major problems faced by the industry and to assess quality parameters of cleft and the wood used for making these clefts. Shortage of quality raw material, absence of proper marketing channels and irregular electricity supply were the major factors responsible for production shortfall. The units used wood of Salix alba var. caerulea as main raw material while Populus deltoides wood was also used for low quality bats. For the study, latest available official records of Government of Jammu and Kashmir as well as questionnaire based sample survey data were used. The industry produced 15.10 crore clefts that consumed 17,28,532 ft 3 of wood. Sample survey revealed that in 2016, the selected 62 units procured 5,84,557 ft3 of wood with an average of 9,428.33 ft3 per unit.
Use of Botanicals Plant for Stored Grain Pest Management: A Critical Review
Authors: Vijayan Roshni , Vidhya C. S.  , Ramkumar  , Saurabh  , Sarkar Neladri Sekhar , Maheshwari Sourabh , Anto Rashwin A.  , Brajendra
Published: November 2023

The current paper has been studied to understand the significance of various plant products (botanicals) against storage insect pests of seeds and grains. Grain storage is critical in agriculture for the next generation and food security. Insect pests are economically relevant among the several biotic and abiotic elements that impact the fate of grains during storage because they cause significant loss. The expanding demands of the world's growing population can be met by lowering or eradicating the insect pest population while storing. The most damaging storage insect pests are Sitotroga cerealella, Sitophilus sp., Rhyzopertha Dominica, Trogoderma granarium, Tribolium sp., Callosobruchus sp., and others. Insect damage includes the ingestion of seed, exuviae debris, webbing, and cadavers, rendering the grain unfit for human consumption and reducing both quality and quantity. They manipulated the storage environment, resulting in the formation of hotspots that are conducive to the spread of storage fungi and other dangerous microflora. Conventionally, we use synthetic pesticides to manage various insect pests that are hazardous to the environment and ecosystem in a variety of ways, including the elimination of natural enemies, insect resistance and resurgence, making soil, water, and air sick, and having residual effects that cause various disorders or diseases in animals and humans. Botanicals such as neem (Azadirachta indica), Bach (Acorus calamus), phoolakri (Lantana camara), draik (Melia azadarach), kali mirch (Piper nigrum), and basuti (Adhatoda zeylanica) are biodegradable, non-residual, equally effective, and widely available etc. may show to be a superior solution for controlling insect pests, particularly storage pests, without impacting grain or seed quality or harming our ecology or environment. Thus, botanicals can be used alone or in conjunction with IPM to manage insect pests.
PENYESUAIAN SKALA PENILAIAN BEHAVIORAL OBSERVATION BERDASARKAN PROSEDUR OPERASIONAL STANDAR (SOP) PADA KARYAWAN TELLER BANK SWASTA DI SURABAYA
Authors: Tambunan Sihar Tigor Benjamin
Published: November 2023

Abstract in Bahasa Indonesia :

Pekerjaan seorang teller tergolong sebagai pekerjaan non-produksi. Karena itu penilaian hasil kerja pada teller tidak dapat didasarkan pada hasil-hasil yang bersifat kuantitatif. Penilaian kinerja berbasis perilaku seperti BOS dalam menilai kinerja seorang teller akan jauh lebih efektif dan adil karena terfokus pada perilaku-perilaku penting dalam aktifitas keseharian (daily critical incidents) seorang teller.

Dari sisi instrumentasi, prosedur penerapan BOS pada sistem perbankan menjadi sedikit lebih sederhana dibandingkan jenis-jenis perusahaan lain karena bank adalah perusahaan yang sangat birokratis. Artinya, sebenarnya perilaku-perilaku penting seorang teller adalah perilaku-perilaku terstandarisasi (sudah tercantum dalam SOP harian), dan hampir tidak mungkin dapat dimodifikasi untuk menjadi lebih baik oleh seorang teller (better performance). Masalahnya, dalam penilaian kinerja seringkali sebuah perusahaan memerlukan hasil penilaian yang cukup tajam dan lugas terhadap hasil kerja karyawan terutama jika penilaian kinerja berkaitan dengan pelatihan, promosi, dan pemberian bonus. Untuk memenuhi tujuan perusahaan ini, dua buah teknik modifikasi skala penilaian, berupa pemaksaan skala (forced scales) dan penghilangan skala (scales elimination), keduanya disesuaikan dengan karakteristik pekerjaan perbankan, telah diterapkan pada lembar SOP.

Analisis lanjutan berupa analisis statistik sederhana terhadap hasil BOS juga menunjukkan bahwa BOS dapat digunakan sebagai alat untuk mengevaluasi kinerja departemental, dalam hal departemen in front office (teller group), terutama melalui. penggambaran nilai rata-rata perilaku teler ke dalam kurva radar

Kata kunci: PA, BOS, SOP, teller, kejadian kritis.
Perinatal Mental Health Outcomes Following Natural Disasters
Authors: Martínez-González Karen G. , Morou-Bermúdez Evangelia , Buxó Carmen J.
Published: November 2023

This Viewpoint discusses mental health outcomes associated with natural disaster–related stressors during the perinatal period.
Applications of Liquid Biopsy for Surgical Patients With Cancer
Authors: Mahuron Kelly M. , Fong Yuman
Published: November 2023

Importance

Liquid biopsy is an emerging tool with the potential to change oncologic care practices. Optimal clinical applications for its use are currently undefined for surgical patients.

Observations

Liquid biopsy analytes such as circulating tumor cells (CTCs) and circulating tumor DNA (ctDNA) have been the most clinically studied assays and were initially limited to advanced-stage disease. In the metastatic setting, CTCs and ctDNA levels are prognostic. Although their levels correlate with treatment response, CTC-guided systemic regimen switches for nonresponders have not been shown to improve clinical outcomes. ctDNA genomic profiling has succeeded, and there are now multiple plasma-based assays approved by the US Food and Drug Administration that can detect actionable mutations to guide systemic therapy. Technological advancements in assay sensitivity have expanded the use of ctDNA to early-stage and resectable disease, allowing for detection of minimal residual disease. Postoperative ctDNA levels are a strong predictor of disease recurrence, and ctDNA detection often precedes serum carcinoembryonic antigen elevation and radiographic changes. However, its use for surveillance has not been shown to improve clinical outcomes. A promising application of ctDNA is for adjuvant therapy escalation and de-escalation. A phase 2 clinical trial demonstrated that treatment de-escalation for patients with high-risk stage II colorectal cancer and negative postoperative ctDNA had similar recurrence-free survival as patients receiving standard-of-care chemotherapy. These results suggest that ctDNA may help select patients who will benefit from adjuvant chemotherapy, and multiple clinical trials are actively underway.

Conclusions and Relevance

Although uncertainties regarding the optimal use of liquid biopsy remain, it has the potential to significantly improve care for patients with cancer at all stages of disease. It is critical that surgeons understand how to use and interpret these assays, and they should be active participants in clinical trials to advance the field.
FluoMALDI Microscopy: Matrix Co‐Crystallization Simultaneously Enhances Fluorescence and MALDI Imaging
Authors: Yang Ethan , Shen Xinyi Elaine , West‐Foyle Hoku , Hahm Tae‐Hun , Siegler Maxime A. , Brown Dalton R. , Johnson Cole C. , Kim Jeong Hee , Roker LaToya Ann , Tressler Caitlin M. , Barman Ishan , Kuo Scot C. , Glunde Kristine
Published: November 2023

Here, the authors report that co‐crystallization of fluorophores with matrix‐assisted laser desorption/ionization (MALDI) imaging matrices significantly enhances fluorophore brightness up to 79‐fold, enabling the amplification of innate tissue autofluorescence. This discovery facilitates FluoMALDI, the imaging of the same biological sample by both fluorescence microscopy and MALDI imaging. The approach combines the high spatial resolution and specific labeling capabilities of fluorescence microscopy with the inherently multiplexed, versatile imaging capabilities of MALDI imaging. This new paradigm simplifies registration by avoiding physical changes between fluorescence and MALDI imaging, allowing to image the exact same cells in tissues with both modalities. Matrix‐fluorophore co‐crystallization also facilitates applications with insufficient fluorescence brightness. The authors demonstrate  feasibility of FluoMALDI imaging with endogenous and exogenous fluorophores and autofluorescence‐based FluoMALDI of brain and kidney tissue sections. FluoMALDI will advance structural‐functional microscopic imaging in cell biology, biomedicine, and pathology.
Model‐based design of stratified packings for enhanced mass transfer using optimal control theory
Authors: Eppink A. , Kuhn M. , Briesen H.
Published: November 2023

Various examples show that stratified columns can improve the transport performance of particle packings. However, to date, there is no universal strategy to design these packings to yield optimal performance. This study proposes a model‐based approach for designing particle packings in which mass transfer occurs between a liquid phase and a stationary phase using optimal control theory. The primary objective is to provide a general design strategy that is applicable across different unit operations in chemical, pharmaceutical, and food applications. Optimal control is utilized to determine the optimal particle diameter as a function of the axial position within the column. We demonstrate the approach using two case studies and three different optimization criteria. Numerical results indicate that the proposed method is highly effective, for example, the solvent demand is reduced by up to . Moreover, the optimally graded packing yields a significantly sharper breakthrough curve of an adsorption column.
Integration analysis of transcriptome and proteome of Chinese Merino sheep (Ovis aries) embryonic skeletal muscle
Authors: Feng Mian , Hu Wenping , Wang Xinyue , Liu Lulu , Liu Yunhui , Zhang Li
Published: November 2023

The growth and development of sheep late fetal skeletal muscle undergoes significant changes. However, the specific mechanism remains unknown. In this study, we performed the comprehensive analysis of transcriptome and proteome of Chinese Merino sheep at embryonic ages Day85 (D85N), Day105 (D105N), and Day135 (D135N) by the tandem mass tags (TMT) and RNA‐seq methods. Totally 717, 1253, and 1873 differentially expressed genes (DEGs) were identified in the three comparison groups (D85N vs. D105N, D105N vs. D135N, and D85N vs. D135N). Among which 7, 80, and 162 DEGs were identified with the same trends at mRNA and protein levels in the three groups. Enrichment analysis showed that 7 genes with same trends in D85 vs. D105 have not been enriched in any pathways, which indicated that the development of skeletal muscle underwent significant changes with post‐transcription regulation during this period. These genes with same trends in D105N vs. D135N were mainly enriched in the pathways related to skeletal muscle metabolism and maturation, including oxidative phosphorylation, glycolysis/gluconeogenesis, tight junction, and HIF‐1 pathways, which indicated that the development of skeletal muscle tended to maturation during this period. These results provided evidence for ovine late fetal skeletal muscle fibers development from proliferating to thickening at simultaneous transcriptional and translational levels.
Triptolide Reduces MDA‐MB‐231 Cell Metastasis by Attenuating Epithelial‐Mesenchymal Transition through the ROCK/PTEN/Akt Axis
Authors: Wu Qinhang , Leng Xuejiao , Ma Xuelin , Xu Qixuan , Ni Ruijun , Pan Yang , Jin Zhuolin , Kalim Muhammad
Published: November 2023

Triple‐negative breast cancer (TNBC) is a highly heterogeneous and invasive subtype of breast cancer. The prognosis of TNBC is poor because of its high distant metastasis rate. Triptolide is a type of diterpene trioxide natural compound with potential anti‐tumor activities. This study explored the metastatic inhibitory effect of triptolide on MDA‐MB‐231 cells and its underlying mechanism. Triptolide suppressed cell proliferation and induced cell apoptosis in a time‐ and dose‐dependent manner. Low doses of triptolide (0‐8 nM) reduced the migration and invasion capabilities of MDA‐MB‐231 cells. Triptolide decreased ROCK1, p‐Akt, N‐cadherin, vimentin and MMP‐9 expressions, but increased PTEN and E‐cadherin expressions on protein and mRNA levels. Furthermore, the down‐regulation of ROCK1 expression in MDA‐MB‐231 cells after being treated by triptolide could be rescued by ROCK1 specific inhibitor Y27632. Molecular docking showed that triptolide and Y27632 shared the same active center of ROCK1 protein. This article‘s findings taken together showed that ROCK1 is the primary target of triptolide, which can cause cell apoptosis and inhibit the epithelial‐mesenchymal transition of MDA‐MB‐231 cells.
Ferruginoside D: A Novel Phenylethanoid from Verbascum leiocarpum
Authors: Şimşek Samed , Akşit Hüseyin , Aydın Ali , Köksal Ekrem
Published: November 2023

A novel phenylethanoid, ferruginoside D, together with fourteen known compounds were isolated from the Verbascum leiocarpum for the first time. Chemical structures of isolated compounds were determined by spectroscopic analysis including HR‐ESI‐MS and NMR spectra. The antioxidant, α‐glucosidase inhibitory properties, and antiproliferative activities against multiple cell lines (A172, C6, HeLa, A2780, SW620, HT29, Beas2B, RPE, and HSF) of the isolated compounds were evaluated in vitro. According to the results, iridoids, flavonoids (luteolin and apigenin), and phenylethanoids (poliumoside and isoverbascoside) with strong antiproliferative potential were also found to have cytostatic effects. Furthermore, the investigation revealed that compounds luteolin, poliumoside, verbascoside, isoverbascoside, ferruginoside C, ferruginoside D, and ursolic acid show potent alpha‐glucosidase inhibitory activity, while compounds luteolin, verbascoside, and isoverbascoside exhibit substantial antioxidant activity. The new compound (ferruginoside D) was found moderately active against cancer cell lines, with strong alpha‐glucosidase inhibitory activity, and moderate antioxidant properties.
Egg white improved the quality of noodles with high mung bean content by protein aggregation behavior
Authors: Li Ruoning , Wang Li , Hou Dianzhi , Zhou Sumei
Published: November 2023

Background and Objectives

Mung bean, as a coarse grain, is rich in protein and phytochemicals. Noodles prepared from mung bean are nutritionally superior to traditional noodles. However, the absence of gluten protein in mung bean limits their incorporation level and might cause adverse effects on the quality of noodles. To address the quality degradation of noodles with high mung bean content due to the lack of gluten proteins, the effects of fresh egg white on their quality improvement were investigated. In this study, the dynamic rheological properties of the dough as well as the changes in free sulfhydryl and SS bonds were determined. The cooking characteristics, sensory, textural properties, and microstructure of the noodles were evaluated.

Findings

Results revealed that the addition of 15% fresh egg white significantly improved the sensory scores of the wheat–mung bean (3:7) composite noodles, which might be attributed to the enhanced modulus of elasticity (G′) of the composite dough system, the increased hydrophilicity, and amount of free sulfhydryl and SS bonds in noodles. Meanwhile, scanning electron microscopy and confocal laser scanning microscopy further confirmed that the addition of 15% fresh egg white affected the structures of starch granule and protein network. Furthermore, the addition of 15% fresh egg white minimized the cooking loss and enhanced the springiness, adhesiveness, and chewiness of the noodles, which in turn resulted in the highest sensory scores.

Conclusions

The incorporation of 15% fresh egg white could enhance the quality characteristics of mung bean noodles by protein aggregation, thus receiving a favorable acceptance.

Significance and Novelty

This study explored the possibility of developing a novel noodle with 70% mung bean content. Moreover, the addition of 15% fresh egg white could significantly improve its quality and overall acceptability. This result contributes to the development of high‐content gluten‐free cereal or other legume noodles.
Kdm7a expression is spatiotemporally regulated in developing Xenopus laevis embryos, and its overexpression influences late retinal development
Authors: Martini Davide , Digregorio Matteo , Voto Ilaria Anna Pia , Morabito Giuseppe , Degl'Innocenti Andrea , Giudetti Guido , Giannaccini Martina , Andreazzoli Massimiliano
Published: November 2023

Background

Post‐translational histone modifications are among the most common epigenetic modifications that orchestrate gene expression, playing a pivotal role during embryonic development and in various pathological conditions. Among histone lysine demethylases, KDM7A, also known as KIAA1718 or JHDM1D, catalyzes the demethylation of H3K9me1/2 and H3K27me1/2, leading to transcriptional regulation. Previous data suggest that KDM7A plays a central role in several biological processes, including cell proliferation, commitment, differentiation, apoptosis, and maintenance. However, information on the expression pattern of KDM7A in whole organisms is limited, and its functional role is still unclear.

Results

In Xenopus development, kdm7a is expressed early, undergoing spatiotemporal regulation in various organs and tissues, including the central nervous system and the eye. Focusing on retinal development, we found that kdm7a overexpression does not affect the expression of genes critically involved in early neural development and eye‐field specification, whereas unbalances the distribution of neural cell subtypes in the mature retina by disfavoring the development of ganglion cells while promoting that of horizontal cells.

Conclusions

Kdm7a is dynamically expressed during embryonic development, and its overexpression influences late retinal development, suggesting a potential involvement in the molecular machinery regulating the spatiotemporally ordered generation of retinal neuronal subtypes.
Calm after the storm? Similar patterns of genetic variation in a riverine foundation species before and after severe disturbance
Authors: Ngeve Magdalene N. , Engelhardt Katharina A. M. , Gray Michelle , Neel Maile C.
Published: November 2023

In summer 2011, Tropical storms Lee and Irene caused an estimated 90% decline of the submersed aquatic plant Vallisneria americana Michx. (Hydrocharitaceae) in the Hudson River of New York (USA). To understand the genetic impact of such large‐scale demographic losses, we compared diversity at 10 microsatellite loci in 135 samples collected from five sites just before the storms with 239 shoots collected from nine sites 4 years after. Although 80% of beds sampled in 2011 lacked V. americana in 2015, we found similar genotypic and genetic diversity and effective population sizes in pre‐storm versus post‐storm sites. These similarities suggest that despite local extirpations concentrated at the upstream end of the sampling area, V. americana was regionally resistant to genetic losses. Similar geographically based structure among sites in both sampling periods suggested that cryptic local refugia at previously occupied sites facilitated re‐expansion after the storms. However, this apparent resistance to disturbance may lead to a false sense of security. Low effective population sizes and high clonality in both time periods suggest that V. americana beds were already small and had high frequency of asexual reproduction before the storms. Dispersal was not sufficient to recolonize more isolated sites that had been extirpated. Chronic low diversity and reliance on asexual reproduction for persistence can be risky when more frequent and intense storms are paired with ongoing anthropogenic stressors. Monitoring genetic diversity along with extent and abundance of V. americana will give a more complete picture of long‐term potential for resilience.
α‐CF3‐Substituted Saturated Bicyclic Amines: Advanced Building Blocks for Medicinal Chemistry
Authors: Smyrnov Oleh , Melnykov Kostiantyn P. , Semeno Volodymyr , Liashuk Oleksandr S. , Grygorenko Oleksandr O.
Published: November 2023

A straightforward approach to α‐CF3‐substituted saturated bicyclic amines starting from commercially available compounds is proposed. The key steps include addition of the Ruppert‐Prakash reagent to imine moiety and AlMe3‐promoted intramolecular heterocyclization. The reaction sequence provides access to fluorine‐containing azabicyclo[n.2.1]alkane (n=1–3) or azabicyclo[2.2.2]octane derivatives in 10–42 % overall yield. The physicochemical properties of the prepared compounds or their model derivatives (i. e., pKa and LogP) were measured and compared to those for the parent monocyclic or non‐fluorinated saturated heterocycles. As expected, amine basicity was lowered considerably upon introduction of the CF3 group (ΔpKa≈4), while the lipophilicity increased (by ca. 0.5 LogP units). The summarized data provides a convenient guideline for application of the synthesized compounds in drug discovery programs.
Organocatalyzed Kinetic Resolution of Racemic Carboxylic Acids
Authors: Okuno Ken , Furuya Yasuaki , Shirakawa Seiji
Published: November 2023

The kinetic resolution of racemic compounds is a reliable method to prepare important chiral molecules in highly optically enriched forms. Although methods for the catalytic kinetic resolution of chiral alcohols, amines, and epoxides have been extensively investigated, the kinetic resolution of racemic carboxylic acids has remained under‐developed despite the importance of chiral carboxylic acids. Excellent catalytic approaches for the kinetic resolution of racemic carboxylic acids via esterification using chiral organocatalysts have been reported by several research groups. Furthermore, the organocatalyzed lactonization of alkenyl and alkynyl carboxylic acids has also been adapted to achieve kinetic resolution. Herein, the methods typically used to produce the organocatalyzed kinetic resolution of racemic carboxylic acids are reviewed to elucidate the current status of this research.
Evolutionary medicine approaches to chronic disease: The case of irritable bowel syndrome
Authors: Lenover Makenna B. , Shenk Mary K.
Published: November 2023

Irritable bowel syndrome (IBS), a gastrointestinal disease, is a global phenomenon correlated with industrialization. We propose that an evolutionary medicine approach is useful to understand this disease from an ultimate perspective and conducted a scoping literature review to synthesize the IBS literature within this framework. Our review suggests five potential evolutionary hypotheses for the cause of IBS, including (a) a dietary mismatch accompanying a nutritional transition, (b) an early hygienic life environment leading to the immune system and microbiotic changes, (c) an outcome of decreased physical activity, (d) a response to changes in environmental light–dark cycles, and (e) an artifact of an evolved fight or flight response. We find key limitations in the available data needed to understand early life, nutritional, and socioeconomic experiences that would allow us to understand evolutionarily relevant risk factors and identify a need for further empirical research to distinguish potential causes and test evolutionary hypotheses.
Prognostic role of the MRI‐based involvement of superior pharyngeal constrictor muscle in oropharyngeal squamous cell carcinoma
Authors: Tirelli Giancarlo , Marcuzzo Alberto Vito , Gardenal Nicoletta , Tofanelli Margherita , Degrassi Ferruccio , Cova Maria Assunta , Sacchet Erika , Giudici Fabiola , Polesel Jerry , Boscolo‐Rizzo Paolo
Published: November 2023

Objectives

The aim of this study was to determine the impact of the involvement of the superior pharyngeal constrictor muscle (SPCM) evaluated by magnetic resonance imaging (MRI) on outcome in oropharyngeal squamous cell carcinomas (OPSCCs).

Methods

A retrospective study including consecutive patients with OPSCC treated with curative intent.

Results

A total of 82 consecutive patients with OPSCC met inclusion criteria. At multivariate analysis, patients with SPCM infiltration were at significantly higher risk of death (HR: 3.37, CI: 1.21–9.38) and progression (HR: 3.39, CI: 1.38–8.32). In a multivariate model conditioned on HPV status, a significantly higher risk of death and progression was observed by combining both SPCM and HPV status with patients harboring an HPV‐negative OPSCC with SPCM infiltration showing the poorest outcome.

Conclusion

MRI evidence of SPCM involvement significantly and independently increases the risk of death and progression in subjects with OPSCC. Considering both MRI‐assessed SPCM infiltration and HPV status significantly improved risk stratification in these malignancies.