bluuebunny/crossref_metadata_2025 huggingface dataset:
Functional assessment of patients with systemic scleroderma. Recommendations for physiotherapists
Authors: Łuczak Joanna , Szczerba Michał , Szymańska Elżbieta , Jarosz-Popek Joanna , Czaplicka Anna , Walecka Irena
Published: May 2024

Aim: To analyze the functional performance of patients with generalized scleroderma treated at the Department of Dermatology of the PIM of the Ministry of Internal Affairs and to develop recommendations for physiotherapists. Systemic sclerosis (SSc) is a chronic connective tissue disease characterized by progressive fibrosis of the skin and internal organs, the presence of microcirculatory disorders and the presence of autoantibodies.
Materials and Methods: The study group consisted of 55 patients aged 27 years to 80 (mean 56.4) with systemic scleroderma, who receive rheological treatment in the Department of Dermatology on a cyclical basis. In addition, pharmacotherapy was supported by individually tailored rehabilitation for 2 years. Before and after the completed therapy, the results of the study were analyzed and recommendations were created for physiotherapists. Forty-two participated in the study.
Results: All patients had mobility restrictions in the proximal and distal interphalangeal joints of both hands and in both temporomandibular joints. Conclusions: The study confirmed the need for guidelines for physiotherapists.
Physical activity and life satisfaction of students of physiotherapy and physical education at the close of the COVID-19 pandemic
Authors: Shpakou Andrei , Baj-Korpak Joanna , Kowalczuk Krystyna , Sokołowska Dorota , Naumau Ihar A. , Korpak Filip
Published: May 2024

Aim: To learn and compare their level of physical activity (PA) and motivation declared by physical education students and future physiotherapists, as well as to evaluate their life satisfaction in the final phase of the pandemic of the COVID-19 pandemic.
Materials and Methods: A survey study covered 211 respondents (106 students of physical education (PE) and 105 future physiotherapists). The anonymous survey consisted of standardized questions regarding the level and goals of physical activity (IPAQ-SF and IPAO) and life satisfaction (SWLS).
Results: A high level of PA was demonstrated by 51.5% of men and 48.6% of women – 83.1% and 75.9% students of physiotherapy and physical education, respectively. Family was a determinant that did not motivate the students to take up physical activity. There was a better atmosphere in the professional environment encouraging physical activity in the group of PE students (3.19}1.28) than among future physiotherapists (2.82}1.28) (p<0.001). Future physiotherapists declared lower level of life satisfaction. In this group, the SWLS score was 23.5}5.95 compared to 25.4}5.45 among PE students.
Conclusions: At the close of the COVID-19 pandemic, the specificity of PE and physiotherapy studies as well as gender are variables that had a significant impact on the resumption, type and motives for undertaking physical activity and improving life satisfaction. PE students’ perception of the importance of physical activity is more pronounced than that of future physiotherapists, which is a strong enough factor to increase their life satisfaction.
The study of sexual dimorphism based on the values of the finger index “2D:4D” in pair-group acrobatics
Authors: Bachynska Nataliia Veronika , Boguslavsky Viktor , Markov Roman , Polyvaniuk Vasyl , Kurta Yevhen , Vilyanskyi Volodymyr , Stavenko Vitalii
Published: May 2024

Aim: Research and determination of the degree of manifestation of the inversion of sexual dimorphism using the study of the “2D:4D” index finger in acrobats of various roles and genders and non-athletes.
Materials and Methods: Pair-group acrobatics athletes, as well as peers who do not play sports, were studied. Acrobatic girls: roles at the top (n=32), age 13.96}1.02; roles in the middle and at the bottom (n=42), age19.36}2.86. Young acrobats: roles above (n=32), age 14.88}2.32; roles in the middle and elow (n=48), age 20.38}2.89 (beginners, sub-elite and elite athletes). Statistical processing was performed using the STATISTICA 10.0 computer program: arithmetic mean (X), standard deviation (SD), standard error of the arithmetic mean (m), Brave-Pearson correlation analysis (r), the non-parametric U-Mann-Whitney statistical test, the Wilcoxon T test.
Results: In female athletes, in the middle and below, the female and equal type of hand bone was found in 76.20% of athletes, the male type of hand bone –in 23.80% of the subjects. In the male acrobats of those in the middle and below the male hand bone type was found in 100% of the athletes and the female hand bone type was found in none of those studied.
Conclusions: In male acrobats, not a single case of female hand bone type was found according to the “2D:4D” index finger, all subjects with male hand bone type. The feminine and equal type is found in a small percentage of young men who do not play sports.
On the role of professional accounting and economic personnel in the development of the accounting and auditing system of higher educational institutions of the Kyrgyz Republic
Authors:   International University of Innovative Technologies, Bishkek, Kyrgyz Republic, Murzasheva J. V.
Published: May 2024

The article is devoted to the study of the role of professional accounting and economic personnel in the development of the accounting and auditing system of higher educational institutions of the Kyrgyz Republic. The existing system does not fully meet the increased requirements for control, leadership and management. Accounting in higher education institutions of the republic is organized mainly according to the book and journal form of accounting using partial automation in certain areas. There are shortcomings in accounting for inventories, elements of the normative method of accounting for educational expenses are not used, there is no unified unified system of documentation and classification of accounting nomenclatures. None of the universities in Kyrgyzstan has fully implemented accounting automation. There are practically no design solutions in this area, with the exception of the automation project in universities developed by the PC Research Institute. Accounting and planning of expenses for the maintenance of universities in Kyrgyzstan are carried out according to the established nomenclature corresponding to the classification of budget expenditures. It does not always meet the requirements of planning, accounting and analysis and therefore cannot be considered as a single cost grouping. To determine the costs of the current maintenance of universities, two methods are used: the rationing method and the method based on the average costs that have developed over a number of years. The first method is used to calculate variable costs, the second is permanent.
On the methodology for analyzing the effectiveness of economic activity of economic entities of Kyrgyzstan
Authors:   International University of Innovative Technologies, Bishkek, Kyrgyz Republic, Akylbekova E. K.
Published: May 2024

The article is devoted to the methodology of analyzing the main indicators of economic activity of an enterprise based on the balance sheet. Proper organization of settlement operations ensures a stable turnover of funds of an economic entity, strengthening of settlement discipline and improvement of its financial condition. Since making a profit is a prerequisite for commercial activity, and the financial stability of an enterprise is largely determined by the amount of profit received, the analysis of financial results becomes very relevant. The article discusses options for business activity based on the balance sheet of the enterprise and ways to further improve economic activity. Managers cannot choose a development strategy appropriate to the situation in the entities without first assessing all the opportunities in the sector, as well as the growth and potential profitability that each of them provides. When assessing the industry’s capabilities and their attractiveness, managers should take into account that the interests of the industry and the economic entity do not always coincide.
Audit and internal control as a key to reliability and completeness of information about the economic use of resources of commercial enterprises
Authors:   International University named after K. Sh. Toktomamatova, Jalal-Abad, Kyrgyz Republic, Kambarova Aiperi S.
Published: May 2024

This article is devoted to the issues of auditing internal control of commercial enterprises as a guarantee of reliability and completeness of information on the economical use of resources of commercial enterprises. Internal control is a process that must ensure that actual results coincide with those planned, all other things being equal. The control process involves setting goals or standards (often calculated during budgeting) against which actual results are compared. Performance indicators are then periodically measured and compared with targets. Accountants must provide information to managers as feedback in the form of periodic reports that allow managers to determine whether operations are being carried out according to plan and to identify those activities where adjustments are necessary. In particular, one of the functions of management accounting is to provide managers with economic feedback that helps control costs and improve the efficiency and productivity of operations.
MEDIASI PENGARUH SIKAP KEUANGAN DAN KEPRIBADIAN TERHADAP PERILAKU PENGELOLAAN KEUANGAN MELALUI LITERASI KEUANGAN
Authors: Nanda Helen Dwi , Christiana Irma
Published: May 2024

ABSTRACTThis research aims to analyze and determine the influence of financial attitudes and personalities on financial management behavior, with financial literacy as an intervening variable. This research is quantitative descriptive research, and the data types are primary and secondary data. The population in this study were active students in Medan City. The sample in this study using the Lemeshow formula consisted of 96 students. The data analysis technique uses factor analysis, namely confirmatory factor analysis (CFA) using the structural equation model (SEM) with the SmartPLS 3 application. The results of the research conclude that financial attitudes have no effect on financial literacy or financial management behavior. Personality has a significant effect on financial literacy and financial management behavior. Financial literacy is able to mediate the influence of financial attitudes and personalities on financial management behavior.Keywords: financial attitudes; personality; financial management behavior; financial literacy.ABSTRAKPenelitian ini bertujuan untuk menganalisis dan mengetahui pengaruh sikap keuangan dan kepribadian terhadap perilaku pengelolaan keuangan dengan literasi keuangan sebagai variable intervening. Penelitian ini merupakan penelitian deskriptif kuantitatif, sedangkan jenis data berupa data primer  dan skunder. Populasi dalam penelitian ini adalah mahasiswa aktif di Kota Medan. Sampel dalam penelitian ini menggunakan rumus Lemeshow berjumlah 96 orang mahasiswa. Teknik analisis data menggunakan analisis faktor yaitu Confirmatory Factor Analysis (CFA) dengan menggunakan model persamaan Structural Equation Model (SEM) dengan aplikasi SmartPLS 3. Hasil penelitian menyimpulkan bahwa sikap keuangan tidak berpengaruh terhadap literasi keuangan dan perilaku pengelolaan keuangan. Kepribadian berpengaruh signifikan terhadap literasi keuangan dan perilaku pengelolaan keuangan. Literasi keuangan mampu memediasi pengaruh sikap keuangan dan kepribadian terhadap perilaku pengelolaan keuangan.Kata Kunci: sikap keuangan; kepribadian; perilaku pengelolaan keuangan; literasi keuangan.
Praktik Pengembangan Kurikulum dan Model-Model Pembelajaran Qur’an Hadits di Mts Muhammadiyah 3 Masaran
Authors: Anastasia  , Munadi Muhammad
Published: May 2024

Tujuan penelitian untuk mengetahui praktik pengembangan kurikulum dan model-model pembelajaran Qur’an Hadits di MTs Muhammadiyah 3 Masaran. Metode riset menggunakan metode penelitian kualitatif. Pengumpulan data menggunakan observasi, wawancara, dan dokumentasi. Keabsahan data menggunakan triangulasi metode dan triangulasi sumber. Analisis data dengan menggunakan pengumpulan data, reduksi data, penyajian data, dan penarikan kesimpulan. Hasil penelitian menunjukkan bahwa Pengembangan kurikulum yang di lakukan di MTs Muhammadiyah 3 Masaran menggabungkan beberapa kurikulum diantaranya kurikulum Kementerian Agama, kurikulum merdeka, kurikulum 2013, dan kurikulum ISMUBA. Kurikulum tersebut ditunjang dengan kegiatan Baca Tulis Al-Qur’an. Adapun model pembelajaran Qur’an Hadits yang digunakan di MTs Muhammadiyah 3 Masaran adalah model pembelajaran kontekstual dengan mengaitkan pembelajaran dengan kehidupan sehari-hari. Dan menggunakan pendekatan saintifik yaitu meliputi mengamati, menanya, mengeksplorasi, mengasosiasi, dan mengkomunikasikan hasil diskusi. Adapun penerapannya pada pembelajaran Qur’an Hadits yaitu siswa mengamati penjelasanan dari guru, melakukan pertanyaan pada pelajaran yang tidak dipahami, mengeksplorasi materi dari berbagai sumber baik buku maupun internet, melakukan diskusi dengan teman sebaya, dan mengkomunikasikan hasil belajar di depan kelas dan dikaitkan dengan kehidupan sehari-hari.
The purpose of the study is to determine the practice of curriculum development and learning models of the Qur'an Hadith in MTs Muhammadiyah 3 Masaran. Research methods use qualitative research methods. Data collection uses observation, interviews, and documentation. The validity of the data uses method triangulation and source triangulation. Data analysis using data collection, data reduction, data presentation, and drawing conclusions. The results showed that the curriculum development carried out at MTs Muhammadiyah 3 Masaran combined several curricula including the Ministry of Religion curriculum, independent curriculum, 2013 curriculum, and ISMUBA curriculum. The curriculum is supported by Qur'an Literacy activities. The Qur'an Hadith learning model used in MTs Muhammadiyah 3 Masaran is a contextual learning model by relating learning to daily life. And using a scientific approach that includes observing, questioning, exploring, associating, and communicating the results of discussions. As for its application to the learning of the Qur'an Hadith, students observe explanations from the teacher, do questions on lessons that are not understood, explore material from various sources, both books and the internet, conduct discussions with peers, and communicate learning outcomes in front of the class and are associated with daily life.
Penguatan Pendidikan Karakter dalam Integrasi Nilai-Nilai Islami
Authors: Latifah Milahtul , Fatchiatuzahro  , Irawan Heri
Published: May 2024

Pendidikan karakter dalam konteks Islam mengintegrasikan pembelajaran agama dengan pengembangan nilai-nilai moral dan etika, sehingga mencakup aspek keseluruhan dari kehidupan individu. Pendekatan Participatory Action Research (PAR) dalam Program Kreativitas Mahasiswa (PKM) merupakan suatu metode penelitian partisipatif yang melibatkan aktifitas kolaboratif antara para peneliti dan masyarakat yang menjadi subjek penelitian. Tujuannya adalah untuk tidak hanya menghasilkan pengetahuan akademik, tetapi juga untuk memberdayakan masyarakat dalam mengatasi masalah dan memenuhi kebutuhan praktis mereka, serta merangsang perubahan sosial yang lebih luas. Pendidikan karakter yang di bagun di SMP Bina Mandiri peserta didik dan anak didik memiliki 3 faktor Pendidikan karakter yang di tanamkan yaitu:  di keluarga, di sekolah dan lingkungan. Pertama, Keluarga memberikan nuansa yang mempengaruhi anak sesuai dengan ayat-ayat sebagai berikut: Q.S (4): 9, Q.S. (8): 28, dan Q.S (64): 14. Adapun metode pembentukan karakter dikeluarga yaitu: 1) metode keteladanan, 2) metode pembiasaan 3) metode nasihat, 4) metode perhatian dan 5) metode hukuman, hal ini sesuai dengan ayat al-Qur’an Q.S (66):6, Q.S (16): 78
Pendampingan Penggunaan Media Alat Peraga Edukatif sebagai Upaya Peningkatan Kosakata Bahasa Arab di SMP Assiroj Bogor
Authors: Fahmi Nurul , Apriyanti Intan
Published: May 2024

Pembelajaran yang menarik dan mengasyikkan adalah pembelajaran yang meningkatkan motivasi siswa untuk berpartisipasi aktif dalam pelajaran. Proses pembelajaran seperti itu dapat membantu siswa agar lebih paham dan menguasai pelajaran yang diajarkan. Untuk menghasilkan pembelajaran yang dapat menarik minat siswa tidak cukup hanya dengan memberi ceramah dan menuliskan materi secara panjang lebar di papan tulis. Namun, diperlukan sebuah media pembelajaran atau alat bantu yang dapat mendukung guru untuk memudahkan mereka menyampaikan materi kepada para siswa. Kegiatan pengabdian kepada masyarakat ini menggunakan konsep service  learning yang merupakan salah satu model belajar eksperimental dengan memberikan layanan kepada masyarakat mengenai strategi belajar dan mengajar melalui integrasi pembelajaran kelas dengan kebutuhan dan isu-isu yang ada dalam masyarakat. Mengacu pada Kaye. Media alat peraga edukatif ini dibuat dengan mencari gambar-gambar beserta kosakata bahasa Arab yang akan dipelajari melalui internet kemudian mencetaknya, setelah gambar dan kosakata tersebut tercetak, langkah selanjutnya adalah mengguntingnya sesuai ukuran yang diperlukan. Setelah gambar selesai digunting, peneliti menyiapkan beberapa batang lidi dan lem kerta untuk menempelkan gambar dan kosakata bahasa Arab tersebut.
Interesting and exciting learning is learning that increases students' motivation to actively participate in lessons. Such a learning process can help students to better understand and master the lessons being taught. To produce learning that can attract students' interest, it is not enough just to give lectures and write the material at length on the blackboard. However, learning media or tools are needed that can support teachers to make it easier for them to convey material to students. This community service activity uses the concept of service learning, which is an experimental learning model by provides services to the community regarding learning and teaching strategies through integrating classroom learning with the needs and issues that exist in society. Referring to Kaye. This educational teaching aid media is made by searching for pictures along with the Arabic vocabulary to be studied via the internet and then printing them. After the pictures and vocabulary are printed, the next step is to cut them out according to the required size. After the picture had been cut out, the researcher prepared several sticks and paper glue to attach the picture and Arabic vocabulary.
Practical implications of androgen receptor inhibitors for prostate cancer treatment
Authors: Campodonico Fabio , Foppiani Luca , Campodonico Vittoria , Introini Carlo
Published: May 2024

Antiandrogens have been used for the treatment of prostate cancer as a single agent or in combination with hormone deprivation therapy. New generation antiandrogens act like androgen receptor inhibitors (ARIs). Their binding complex blocks the pathways of cellular proliferation and differentiation of the prostate. Enzalutamide, apalutamide and darolutamide are the new ARIs that demonstrated acceptable tolerability and toxicity, both active in hormone-sensitive and castration-resistant prostate cancer (CRPC). There is no evidence of superiority of one drug over the other, therefore the therapeutic choice depends on the safety profile in relation to the individual patient, their comorbidities and clinical condition. ARIs have also shown promising results in association with new drugs that are active on patients with metastatic CRPC carrying the mutated breast cancer gene (BRCA). Before undergoing new antiandrogenic therapies, patients should be evaluated for cardiological and metabolic risk and possible drug interactions.
The Role of the Acetylcholine System and Its Components in the Development of Post-COVID Syndromes (Review)
Authors:   Maykop State Technological University, Muzhenya Dmitriy V. , Lysenkov Sergey P.
Published: May 2024

According to the latest data, COVID-19 is classified as a respiratory virus. However, it has been proven to cause a significant multi-organ dysfunction. Despite the increase in the effectiveness of treatment tactics, a post-COVID-19 symptom complex has been observed in patients after recovery, manifesting itself as cephalalgia, brain fog, high fever, muscle weakness and a decrease (or increase) in arterial pressure. To describe this condition, a clinical characteristic has been proposed: post-acute COVID-19 syndrome (PACS). Approximately 57 % of patients hospitalized with COVID-19 have symptoms of PACS even one year after initial infection with COVID-19. This pathological condition is being actively studied, but the question of the causes of PACS and its development mechanisms remains open. One of the possible reasons behind this symptomatology, in our opinion, is a disorder of the body’s acetylcholine system and its components. The acetylcholine system plays an integral role in various physiological and pathophysiological processes, such as the regulation of the muscular system, immune and inflammatory reactions, wound healing, as well as the development of cardiovascular, respiratory and other diseases. A key way of translating acetylcholine signals in the body is through the use of neurotransmission via a chemical synapse. Based on current literature data, there is reason to believe that viral invasion can significantly change the functional activity of the vagus nerve by disrupting signal transmission in a synapse. We believe that the hyperimmune response caused by COVID-19 triggers a chain of pathological mechanisms that are associated with disrupted nitric oxide production and imbalance in acetylcholine and its receptors. An understanding of these processes may open up prospects for improving the effectiveness of treatment and rehabilitation of patients with COVID-19.
Electrophysiological Correlates of Shot Accuracy of Archers with Different Sports Ranks
Authors:   Kuban State University of Physical Culture, Sports and Tourism, Shestakov Oleg I. , Pukhov Aleksandr M. ,   Velikiye Luki State Academy of Physical Education and Sports
Published: May 2024

The purpose of this study was to establish electrophysiological markers of archers’ shot accuracy by correlations between performance and electroencephalogram (EEG) power parameters in athletes of different ranks compared. Materials and methods. The research involved 20 archers shooting the classic bow, who were divided into two groups of 10 subjects each by sports rank: Candidate for Master of Sport and First-Class Sportsman. EEG was recorded using the Encephalan-EEGR-19/26 device (Medikom MTD, Taganrog) in 19 leads according to the 10–20 system. Reference electrodes were placed on the earlobes. Results. It was found that shot accuracy of high-level archers (Candidate for Master of Sport) is marked by an increase in alpha and theta EEG power in the occipito-temporal-frontal regions of the left hemisphere during the preparatory phases of the exercise, and then, by the dissociation of the powers of these frequency ranges while aiming. In contrast, shot accuracy of lower level archers is characterized by a decrease in the power of the main rhythm in the left temporal lead during the first phase of the shot. In the total sample of athletes (regardless of rank) no significant correlations were found in any of the 3365 cases of evaluation of this analytical parameter. Thus, the electrophysiological markers of bow shot accuracy differ between Candidates for Master of Sport and First-Class Sportsmen. The sevenfold greater number of significant correlations (p < 0.05) between EEG parameters and shot accuracy of Candidates for Master of Sport compared to First-Class Sportsmen indicates a high level of development of the Bow Shot functional system of purposeful movements as the skill improves, as well as testifies to the synergism of physiological processes when performing the exercise by Candidates for Master of Sport. The established facts will expand coaches’ physiological understanding of the mechanism of purposeful movements in order to objectively predict sports results.
Correlations Between Rhythmic Activity Parameters of the Human Heart
Authors:   Pitirim Sorokin Syktyvkar State University, Irzhak Lev I. , Russkikh Nadezhda G. , Ignatova Aleksandra N.
Published: May 2024

The purpose of this article was to determine the correlations between the electrical and mechanical parameters of the rhythmic activity of the heart (HRA) in humans taking into account age and the effect of functional loads. Materials and methods. The research involved 146 people of both sexes aged between two hours after birth and 92 years, who were examined using functional tests that differed depending on the age of the subjects. Electrocardiogram (ECG) and heart rate (HR) parameters were recorded in the standard lead II using the Poly-Spectrum ECG system (Neurosoft, Ivanovo). Results. Correlations between HRA parameters can be traced from the first hours of post-embryogenesis throughout the rest of a person’s life. The data obtained indicate a dependence of HRA on the age and on the effect of functional tests, as well as confirm the proposition that there is an inverse relationship between HR dynamics and the dynamics of myocardial electrical parameters. ECG recordings at birth indicate that the correlations between ECG and HR are formed as early as in the prenatal period. Their correlations in people aged between 70 and 92 years indicate a strain associated with the wear and tear of the body’s functional systems. HR and ECG parameters are based on the electrical properties of the myocardium, which are significantly affected by the autonomic nervous system (ANS). A linear range of correlations between HR and ECG intervals was compiled. The maximum values of the duration of the PP interval and TP segment correspond to the minimum HR values. With an increase in HR from 40 to 80 beats/min, the duration of the TP segment decreases twoto three-fold. With HR reaching 120 ± 5 beats/min, the duration of the TP segment drops to zero. Since the increase in HR continues further in response to functional tests, it is obvious that at this stage the process is provided only by the neurohumoral components of the ANS. Due to the maximum variability of the duration of the TP segment, its most important role in the organization of HRA is emphasized.
Neįprastos Laimo boreliozės apraiškos ir diagnostikos galimybės. Literatūros apžvalga
Authors: Biekšaitė Emilija , Simanauskas Kazys
Published: May 2024

Laimo boreliozė – tai Europoje bei Šiaurės Amerikoje plačiai paplitusi erkių pernešama zoonozė, pažeidžianti įvairias žmogaus organų sistemas. Šia literatūros apžvalga siekiama parodyti neįprastų Laimo boreliozės simptomų įvairovę ir galimas klaidas, bandant nustatyti diagnozę; taip pat pateikiamos naujausios užsienio rekomendacijos ligai diagnozuoti. Laimo boreliozė painiojama su dažniau pasitaikančiomis patologijomis, pavyzdžiui, celiulitu, dilgėline, Belo paralyžiumi, infekcine mononukleoze. Serologiniai tyrimai dažnu atveju padeda patvirtinti diagnozę. Naujausiose rekomendacijose laboratoriniai tyrimai, įtariant šią ligą, skirstomi pagal tai, kokiai stadijai priskiriami paciento simptomai. Tais atvejais, kai infekcija nustatyta anksčiau, ji pakartotinai diagnozuojama tik iš klinikinių simptomų dėl serologinių tyrimų rezultatų ilgaamžiškumo. Endeminėse vietovėse gydytojams svarbu atsižvelgti į didelę Laimo boreliozės simptomų įvairovę, norint laiku diagnozuoti ligą bei pradėti gydymą, išvengiant galimų liekamųjų reiškinių.
NAD – tai raktas į ilgaamžiškumą
Authors: Čapkauskienė Sandrija
Published: May 2024

Nikotinamidadenindinukleotidas (NAD+) – tai labai svarbus kofermentas, esantis kiekvienoje gyvoje ląstelėje, dalyvaujantis daugybėje metabolinių procesų, susijusių su ląstelių bioenergetika. Streso sąlygomis sumažėja NAD+ biosintezė ir jo kiekis, taip pat padidėja jį vartojančių fermentų aktyvumas. Dėl šios priežasties NAD+ dažnai tiriamas senėjimo, vėžio, neurodegeneracinių ir medžiagų apykaitos sutrikimų kontekste. Maistiniai pirmtakai gali paskatinti NAD+ biosintezę ir padidinti viduląstelinį lygį, todėl tai gali būti potenciali fiziologinio nuosmukio ir ligų prevencijos strategija.
Pengaruh Injeksi Surfactant Terhadap Nilai Recovery Factor dan Cummulative Production
Authors: Ananda Tiara , Dewi Aqilah Shafa
Published: May 2024

Dengan adanya beragam kekayaan yang dimiliki Indonesia, kekayaan dalam hal sektor energi dan mineral masih menjadi tumpuan energi utama negara ini, terutama dalam sektor industri perminyakan. Akan tetapi, cadangan minyak yang ada akan terus mengalami penyusutan jika tidak adanya tambahan produksi. Oleh karena itu, perlu adanya suatu metode lanjutan agar cadangan minyak yang ada tidak mengalami penyusutan yang berakibat tidak seimbangnya tumpuan energi Indonesia. Salah satu metode yang bisa digunakan untuk menambah nilai perolehan minyak yaitu melalui metode Enhanced Oil Recovery (EOR). Metode Enhanced Oil Recovery (EOR) adalah metode peningkatan produksi dengan cara menginjeksikan energi eksternal untuk dapat memproduksikan minyak ketika metode primary dan secondary tidak bisa memproduksikan lagi secara ekonomis. Dalam penelitian kali ini akan dibahas mengenai pengaruh injeksi surfaktan dalam metode EOR terhadap perolehan nilai recovery factor (RF) dan nilai kumulatif produksi dalam sumur yang telah dilakukan water flooding sebelumnya. Percobaan ini menggunakan 3 parameter (temperature, laju, dan konsentrasi) yang dilakukan dalam STARS module pada CMG software. Hasil penelitian yang didapatkan yaitu hanya parameter injection rate dan konsentrasi yang hanya memengaruhi nilai oil recovery factor (RF) dan oil cumulative production.
Analisis Laporan Arus Kas Sebagai Alat Ukur Efektivitas Kinerja Keuangan Pada Perusahaan XYZ Tahun 2019-2021
Authors: Krisfiany Friska
Published: May 2024

Kinerja keuangan adalah kondisi keuangan perusahaan/instansi pada suatu periode tertentu baik menyangkut aspek penghimpunan dana maupun penyaluran dana. Kinerja keuangan instansi merupakan prestasi yang dicapai oleh instansi dalam suatu periode tertentu yang mencerminkan tingkat kesehatan instansi tersebut. Tujuan penelitian ini untuk mengetahui kondisi kinerja keuangan pada Perusahaan XYZ dengan menggunakan analisis rasio arus kas. Teknik data yang digunakan yaitu observasi dan studi pustaka. Teknik analisis data yang digunakan dalam penelitian ini yaitu kuantitatif. Metode analisis datanya adalah deskriptif dengan analisis arus kas yang terdiri dari arus kas dari aktivitas operasi, inventasi dan transitoris. Hasil dari penelitian ini dapat diketahui bahwa kinerja keuangan Perusahaan XYZ sudah baik menurut arus kas aktivitas operasi.
Dimensi Teologi Pendidikan Islam Dalam Al Quran
Authors: Cucu Komariah  , Adang  Hambali  , Andewi Suhartini
Published: May 2024

This research analyzes the theological dimensions of Islamic education in the Koran. The research method uses a qualitative type of literature survey (secondary). The data source in this research is to look for literary sources related to the theological dimensions of Islamic education in the Al-Quran in the form of literature studies of various reliable information related to existing problems such as books, magazines, and written materials discussing the substance of God. from all its aspects and its connection with nature. The research results show that theology always means discourse or talk about God. The educational dimensions of human nature and its unique potential are as follows. There are four dimensions: Individual Dimensions, Social Dimensions, Dimensions of Decency, and Religious Dimensions. Possible educational areas for improvement are complete development and incomplete development. The basis of Islamic education is the Koran. Hadith and Ijma.
Invariant representations in abstract concept grounding – the physical world in grounded cognition
Authors: Friedrich Jannis , Fischer Martin H. , Raab Markus
Published: May 2024

Grounded cognition states that mental representations of concepts consist of experiential aspects. For example, the concept “cup” consists of the sensorimotor experiences from interactions with cups. Typical modalities in which concepts are grounded are: The sensorimotor system (including interoception), emotion, action, language, and social aspects. Here, we argue that this list should be expanded to include physical invariants (unchanging features of physical motion; e.g., gravity, momentum, friction). Research on physical reasoning consistently demonstrates that physical invariants are represented as fundamentally as other grounding substrates, and therefore should qualify. We assess several theories of concept representation (simulation, conceptual metaphor, conceptual spaces, predictive processing) and their positions on physical invariants. We find that the classic grounded cognition theories, simulation and conceptual metaphor theory, have not considered physical invariants, while conceptual spaces and predictive processing have. We conclude that physical invariants should be included into grounded cognition theories, and that the core mechanisms of simulation and conceptual metaphor theory are well suited to do this. Furthermore, conceptual spaces and predictive processing are very promising and should also be integrated with grounded cognition in the future.
Inteligência e Interseções Sociais: Compreendendo Comportamentos e Empatia em Sociedades de Alto QI com Ênfase no Espectro Autista
Authors: Agrela Rodrigues Fabiano de Abreu , Henrique dos Santos Nascimento Flávio , Resende da Silva Simone Costa , Gonçalves de Carvalho Luiz Fellipe
Published: May 2024

Este estudo aborda as diferenças comportamentais em sociedades de alto quociente de inteligência (QI), fundamentado em análises e depoimentos de membros dessas sociedades, relatos de vítimas de bullying e contribuições de profissionais das áreas de neuropsicologia, neurociências, psiquiatria, além dos insights do projeto RG-TEA, focado em estudos sobre o autismo. Observou-se que no percentil 98 de sociedades de alto QI, há uma maior incidência de comportamentos agressivos, bullying e perseguição, em contraste com o percentil 99,9, onde esses comportamentos são menos frequentes. A pesquisa revela que a inteligência emocional e social, juntamente com a resiliência, desempenham um papel crucial nas dinâmicas comportamentais desses grupos, além da mera inteligência cognitiva. A análise também destaca a significativa presença de indivíduos autistas com altas habilidades e superdotação no percentil 98. Contrariamente, observa-se uma menor representação de autistas no percentil acima de 99. Muitos diagnósticos de superdotação em autistas estão relacionados à busca ativa por avaliações de QI, frequentemente motivadas por diferenças notadas por pais e profissionais. Notavelmente, autistas com QI acima de 145, frequentemente classificados como Asperger, apresentam uma maior capacidade de sociabilização e controle emocional, sugerindo que a inteligência superior pode compensar os déficits na inteligência emocional e social.
Life Philosophy: A Study on Western Ontology and Taoism of Form and Spirit Dualism
Authors: Ning Dong , Jingxin Pu
Published: May 2024

The paper, starting from the perspective of philosophical exploration of life, combines historical literature with ontology and dualism as the focal points, integrating features from various fields such as psychology, traditional Chinese medicine, and phenomenology. It conducts a comparative study on the similarities and differences between Western ontology and Taoist dualism of form and spirit. The article elucidates how the 'outward-extending material world and inward-purifying spiritual world' are unified in the principle of the amalgamation of 'human body.' It also provides specific methods and theoretical explanations for the discovery of the spiritual world in the East and West.
The external world is defined as the material realm discovered by science, while the internal world is the spiritual realm revealed after the purification of the mind. Both idealism and materialism have tended toward extremes in two directions. Both Western ontology and Eastern Taoist dualism of form and spirit have discovered the phenomenon that 'the spirit can exist independently in this time and space through specific exercises such as meditation.' Taoism, with its unique medical foundation in the study of 'form,' recognizes the interaction of form and spirit, leading to the development of their respective religious, philosophical, and theological traditions. Interdisciplinary and cross-regional studies in religion, particularly in the field of mental and physical health, are expected to become significant trends in the future."
Osteocalcin: Beyond Bones
Authors: Nowicki Jakub Krzysztof , Jakubowska-Pietkiewicz Elżbieta
Published: May 2024

Apart from basic roles such as supporting the body, protecting internal organs, and storing calcium, the skeletal system also performs hormonal functions. In recent years, several reports have been published on proteins secreted by bones and their impact on the homeostasis of the entire body. These proteins include fibroblast growth factor 23, sclerostin, lipocalin 2, and osteocalcin. Osteocalcin, the most abundant non-collagenous protein in bone tissue, is routinely measured as a clinical marker for diagnosing bone metabolism disorders. Its molecule undergoes numerous transformations, with decarboxylation being the critical process. Decarboxylation occurs in the acidic environment typical of bone resorption, facilitating the release of the molecule into the bloodstream and enabling its hormonal action. Decarboxylated osteocalcin promotes insulin secretion and stimulates the proliferation of pancreatic islet β-cells. It also plays a role in reducing the accumulation of visceral fat and decreasing fat storage in the liver. Furthermore, decarboxylated osteocalcin levels are inversely correlated with fasting serum glucose levels, total body fat, visceral fat area, and body mass index. Apart from its role in energy metabolism, osteocalcin affects testosterone production and the synthesis of glucagon-like peptide-1. It is also actively involved in muscle-bone crosstalk and influences cognitive function.
Contemporary echocardiographic assessment of pericardial effusion and cardiac tamponade
Authors: Subotnikov M. V. , Tsyrenov D. D.
Published: May 2024

The aim: the aim of this review is to address the challenges in echocardiographic diagnosis of pericardial effusion, which can potentially lead to a lifethreatening condition called cardiac tamponade. This article discusses the possibilities and prognostic value of transthoracic echocardiography in the diagnosis of pericardial effusion and cardiac tamponade.

Materials and Methods. An analysis of Russian and foreign literature was conducted using eLibrary and PubMed databases. The following keywords were used: «pericardial effusion», «cardiac tamponade», «constrictive pericarditis», «pericarditis», «pericarditis in echocardiography», «перикардиальный выпот», «перикардит», «тампонада сердца», «диагностика перикардита». The included scientific papers and articles were published from 2013 to 2023. The research method used in the analysis was descriptive-analytical.

Results. Pericardial effusion is the accumulation of fluid in the pericardial cavity, which can lead to cardiac tamponade, disrupting normal hemodynamics and cardiac chamber filling, ultimately resulting in systemic hypotension and cardiac arrest. Therefore, it is a life-threatening condition that requires immediate verification, primarily through echocardiography, followed by the determination of treatment strategy. A structured approach, including 2D mode, M-mode, and Doppler echocardiographic assessment, evaluating the quantity and quality of pericardial fluid, cardiac chamber collapse, diastolic ventricular size variability with the respiratory cycle, paradoxical interventricular septum motion, inferior vena cava collapse, respiratory flow variation through valves, and blood flow in hepatic and pulmonary veins, should provide the treating physician with the necessary information for choosing the treatment method. This article discusses key echocardiographic features that will ensure the appropriate assessment of patients with pericardial effusion and/or cardiac tamponade. Among all the mentioned features, the absence of cardiac chamber collapse is likely to have the highest negative prognostic value for excluding cardiac tamponade.
Gender cardiology: clinical and pathophysiological features of the course the main diseases in women
Authors: Davydkin I. L. , Kuzmin V. P. , Zolotovskaya I. A. , Hayretdinov R. K. , Krivova S. P. , Rubanenko O. A.
Published: May 2024

Coronary heart disease is the leading cause of death for both women and men. Older women, when coronary heart disease first appears, have more comorbidities and usually complain of atypical symptoms. Mortality and hospitalization rates caused by acute myocardial infarction are higher for women. It should be noted that adherence to secondary prevention for women is lower.

Female predominance has been noted in idiopathic pulmonary arterial hypertension (IPAH), hereditary pulmonary hypertension, and collagenosisassociated pulmonary arterial hypertension. However, according to the latest data of the European register COMPERA, gender differences disappear for elderly patients and for the patients having concomitant diseases. The more frequent occurrence of cardiomyopathies among women is considered. Peripartum cardiomyopathy associated with pregnancy and childbirth, and Takotsubo cardiomyopathy due to psychoemotional status, in particular a stressful situation, determines a woman's further prognosis. Arrythmias are explained by changes in hormonal status during pregnancy, menopause, or are associated with the onset of the underlying disease.

Heart failure usually affects both sexes equally, with women more likely to suffer from HFpEF and men from HFrEF. The classic cardiovascular, gender, and social risk factors for cardiovascular disease and heart failure have a different meaning for women than for men. It is necessary to take into account the parameters for EchoCG diagnostics for women, since the size of the women heart is smaller.
Eurasian Association of Cardiology (EAC)/ National Society of Heart Failure And Myocardial Disease (NSHFMD) guidelines for the diagnosis and treatment of chronic heart failure (2024)
Authors: Tereshchenko S. N. , Zhirov I. V. , Uskach T. M. , Saidova M. A. , Golicyn S. P. , Rimskaya E. M. , Nasonova S. N. , Narusov O. Yu. , Safiullina A. A. , Tereshchenko A. S. , Stukalova O. V.
Published: May 2024

The purpose of this guide is to assist cardiologists in the management of patients with chronic heart failure (CHF) in accordance with the available modern evidence base. This manual contains data on the diagnosis, treatment, and rehabilitation of patients with chronic heart failure and data on acute decompensation of heart failure.
Оценка чувствительности методов диагностики в выявлении гемодинамически значимых односторонних стенозов почечных артерий
Authors: Erkenova A. M. , Danilov N. M. , Matchin Yu. G. , Kushnir V. V. , Gaman S. A. , Chazova I. E.
Published: May 2024

Objective. Assessment of renal artery stenosis significance in patients with resistant arterial hypertension using non-invasive diagnostic methods and to compare them with the results of selective angiography and methods of physiological assessment of renal artery stenoses.

Materials and methods. Prospectively, 156 patients with drug-resistant arterial hypertension and signs of renal artery stenosis detected by doppler ultrasonography of renal arteries were included in the study. Subsequently, 25 patients were excluded from the study due to multiple variant renal blood supply and bilateral renal artery stenosis. The remaining patients (n=131) underwent selective angiography of renal arteries, and 66 of them additionally underwent CTA of renal arteries with intravenous contrast. If the artery narrowing was 90% or more (n=27) in diameter, the stenosis was considered hemodynamically significant and further stenting of the affected artery was performed, and in case of 60-90% stenosis (n=52) additional assessment of functional significance of the stenosis was performed by measuring translesional pressure gradient, fractional blood flow reserve, instantaneous blood flow reserve (iFR) and Pd/ Pa ratio. 

Results. Among all patients (n=131), in whom the doppler ultrasonography of renal arteries showed signs of unilateral renal artery stenosis, after angiography combined with additional methods of functional significance assessment, hemodynamically significant renal artery stenosis was confirmed in 41% of cases (n=54). Thus, the sensitivity of doppler ultrasonography of renal arteries in detection of hemodynamically significant stenoses was 74%, prognostic value of positive 78% and negative result 64% (p<0,001). According to CTA (n=66) renal artery stenosis was confirmed in 56 patients. The results of CTA of renal arteries in 88% of cases coincided with the results of selective angiography, and using additional functional methods hemodynamically significant stenosis was confirmed in 32 (48%) patients. The sensitivity of CTA in detection of hemodynamically significant stenoses of renal arteries was 69%, specificity 91%, prognostic value of positive and negative results was 91 and 68% respectively. According to selective angiography, out of 131 patients, 24 patients had no renal artery stenosis, 28 patients had stenosis <60%, 27 patients had renal artery stenosis >90% and 52 patients had stenosis 60-90%. Patients with stenosis <60% were not considered candidates for renal artery stenting.
PROGRAMMING BURIAL LANDSCAPES: AN ANALYSIS OF LANDSCAPE REGULATIONS IN LITHUANIA AND THEIR POTENTIAL OUTCOMES
Authors: Bazaraitė Eglė
Published: May 2024

This study explores the regulatory frameworks and landscape designs of burial grounds in Lithuania, focusing on the legal documents and municipal regulations governing cemetery maintenance and development. Analysis reveals a dichotomy between the Law of Burial of Human Remains and the Law of Greenery, with the former emphasizing burial practices and memorial protection while the latter prioritizes ecological considerations and biodiversity in the green areas. Municipal regulations vary in their approach to tree planting and maintenance, with some prohibiting certain species or arbitrary planting. The absence of specific guidelines for designers and administrators grants them flexibility in shaping burial landscapes, leading to diverse approaches across municipalities. Case studies of recently expanded Nemajūnai, Ginkūnai, Daušiškės, and Ivoniškės graveyards illustrate different approaches to tree preservation and landscape design. The findings suggest a need for greater integration of ecological concerns in cemetery planning and maintenance practices.