bluuebunny/crossref_metadata_2025 huggingface dataset:
Chemical and radiation shielding effectiveness of some heavy metal oxide glasses for immobilizing radioactive wastes
Authors: Hussein E. M. Abou , Madbouly A. M.
Published: September 2023

Ce/Sb/Mn different borate glass systems based PbO in concentrations of 50, 35, and 15 mol%, respectively, were prepared by the melting–annealing method. Wide chemical, structural, and radiation shielding characterizations were studied before and after 120 kGy of gamma radiation to test the possible use of glasses for immobilizing radioactive wastes. The results showed suitable density values ranging from 3.34 to 5.30 g/cm3 increased by irradiation. FTIR spectra revealed high structural stability against irradiation correlated to the trigonal BO3, tetrahedral BO4 groups, high polarizable Pb2+ ions, and the doped metal ions. Unexpectedly, the chemical durability after in situ leaching process in H2O, 0.1 N HCl, and 0.1 N NaOH for ~ 3 months revealed clear improving after irradiation e.g., enhanced by ~ 25% for Ce-lead borate glass. Scanning electron microscope (SEM) images of the glass surfaces revealed more smooth and homogenous surfaces after irradiation. Shielding parameters by Monte Carlo code (MCNP5) and Phy-X/PSD software were studied, e.g., mass and linear attenuation coefficients (MAC and LAC), effective atomic number (Zeff), radiation protection efficiency (RPE%), half and tenth value layers (HVL and TVL), and heaviness%. Comparing the shielding behavior of the three glasses revealed that Ce-lead borate glass has the highest values of LAC, MAC, Zeff, heaviness%, and RPE% and the lowest values of HVL, TVL, and MFP, referring to the best shielding efficiency. The whole study indicates the desired properties of glasses as immobilizers or containers for radioactive wastes, e.g., nuclear medicine units in hospitals, especially lead borate glass doped Ce ions.

Graphical Abstract
Not just in black and white: Aboriginal and Torres Strait Islander peoples in Australian children’s picture books
Authors: Zerafa-Payne Emerson , Kerby Martin , Tualaulelei Eseta , Bedford Alison , Baguley Margaret
Published: September 2023

As they are usually chosen by adults, children’s picture books offer important insights into contemporary attitudes and values. They subsequently drive the social and academic development of young children, thereby playing a key role in their ethical socialisation and education. This article will explore the role of children’s literature in this process by analysing a range of Australian children’s picture books that deal with First Nations issues. The books were identified in a survey administered by the State Library of New South Wales’ (NSW) public library service which identified 62 books that explored diversity. Twenty-five of the books were assessed as having Indigenous characters. This article will explore the approach adopted in each of these picture books by using Rudine Sims’ three categories—Social Conscience, Melting Pot, and Culturally Conscious. By doing so, the article will assess the nature of childhood literature’s engagement with Indigenous cultures, contexts, and issues.
Development of landslide susceptibility mapping with a multi-variance statistical method approach in Kepahiang Indonesia
Authors: Putriani Eli , Wu Yih-Min , Chen Chi-Wen , Ismulhadi Arif , Fadli Darmawan Ikhlas
Published: September 2023

Landslides are an example of severe natural disasters that occur worldwide and generate many harmful effects that can affect the stability and development of society. A better-quality susceptibility mapping technique for the landslide risk is crucial for mitigating landslides. However, the use of assemblages of multivariate statistical methods is still uncommon in Indonesia, particularly in the Kepahiang Regency of Bengkulu Province. Therefore, the objective of this study was to provide an improved framework for creating landslide susceptibility map (LSM) using multivariate statistical methods, i.e., the analytical hierarchy process (AHP) method, the simple additive weighting (SAW) method and the frequency ratio (FR) method. In this study, we established a landslide inventory considering 15 causative factors using the area under the curve (AUC) validation method and another evaluation technique. The performance of each causative factor was evaluated using multicollinearity and Pearson correlation analysis with regression-based ranking. The LSM results showed that the most susceptible areas were located in the districts of Kabawetan, Kepahiang, and Tebat Karai. The high landslide risk in these areas could be attributed to the slope conditions in mountainous regions, which are characterized by high annual rainfall and seismic activity. The AUC training values of the AHP, SAW, and FR methods were 0.866, 0.838, and 0.812, respectively. Then, on the validation dataset, the AHP method yielded the highest AUC value (0.863), followed by the SAW (0.833) and FR (0.807) methods. Moreover, the AHP method provided a higher accuracy value, which suggests that the AHP method is more suitable than the other methods. Therefore, our research indicated that all algorithm methods generate a positive impact and greatly improve landslide susceptibility evaluation, especially for the preparation of landslide damage assessments in this study area. Finally, the method proposed in this study could improve the feasibility of LSM and provide support for Indonesian government decision-makers in arranging hazard mitigation measures in the Kepahiang Regency, Indonesia.
Analysis and Evaluation of Feature Selection and Feature Extraction Methods
Authors: Nogales Rubén E. , Benalcázar Marco E.
Published: September 2023

Hand gestures are widely used in human-to-human and human-to-machine communication. Therefore, hand gesture recognition is a topic of great interest. Hand gesture recognition is closely related to pattern recognition, where overfitting can occur when there are many predictors relative to the size of the training set. Therefore, it is necessary to reduce the dimensionality of the feature vectors through feature selection techniques. In addition, the need for portability in hand gesture recognition systems limits the use of deep learning algorithms. In this sense, a study of feature selection and extraction methods is proposed for the use of traditional machine learning algorithms. The feature selection methods analyzed are: maximum relevance and minimum redundancy (MRMR), Sequential, neighbor component analysis without parameters (NCAsp), neighbor component analysis with parameters (NCAp), Relief-F, and decision tree (DT). We also analyze the behavior of feature selection methods using classification and recognition accuracy and processing time. Feature selection methods were fed through seventeen feature extraction functions, which return a score proportional to its importance. The functions are then ranked according to their scores and fed to machine learning algorithms such as Artificial Neural Networks (ANN), Support Vector Machine (SVM), K-Nearest Neighbor (KNN), and Decision Tree (DT). This work demonstrates that all feature selection methods evaluated on ANN provide better accuracy. In addition, the combination and number of feature extraction functions influence the accuracy and processing time.
Shared Listenings
Authors: Östersjö Stefan , Thủy Nguyễn Thanh , Hebert David G. , Frisk Henrik
Published: September 2023

This Element demonstrates how a combination of stimulated recall and collaborative autoethnographic strategies can be applied to artistic and scholarly work at the intersection of ethnomusicology and practice-led-research. The authors relate recently collected material from fieldwork in Vietnam to the long-term method development within the Vietnamese/Swedish group The Six Tones, of which three authors are the founding members. The discussion centers around the inter-subjective forms of stimulated recall analysis, developed through the creative work of this innovative intercultural music ensemble. The aim of this Element is to create a decolonized methodology—for both music performance and research—and it provides a detailed account of this method development starting in 2006. Furthermore, the authors discuss how this practice was successfully shared with three master performers in the south of Vietnam as part of a collaborative project in 2018–2019.
The Ten Commandments
Authors: Hogue Timothy S.
Published: September 2023

The Decalogue, commonly known as the Ten Commandments, is usually analysed as a text. Within the Hebrew Bible, however, it is depicted as a monument– an artifact embedded in rituals that a community uses to define itself. Indeed, the phraseology, visual representations, and ritual practices of contemporary monuments used to describe the Ten Commandments imbue them with authority. In this volume, Timothy Hogue, presents a new translation, commentary, and literary analysis of the Decalogue through a comparative study of the commandments with inscribed monuments in the ancient Levant. Drawing on archaeological and art historical studies of monumentality, he grounds the Decalogue's composition and redaction in the material culture and political history of ancient Israel and ancient West Asia. Presenting a new inner-biblical reception history of the text, Hogue's book also provides a new model for dating biblical texts that is based on archaeological and historical evidence, rather than purely literary critical methods.
The gut microbiome in children with mood, anxiety, and neurodevelopmental disorders: An umbrella review
Authors: Romano Kaitlin , Shah Ashka N. , Schumacher Anett , Zasowski Clare , Zhang Tianyi , Bradley-Ridout Glyneva , Merriman Kaitlyn , Parkinson John , Szatmari Peter , Campisi Susan C. , Korczak Daphne J.
Published: September 2023

Research on the gut microbiome and mental health among children and adolescents is growing. This umbrella review provides a high-level overview of current evidence syntheses to amalgamate current research and inform future directions. Searches were conducted across seven databases for peer-reviewed pediatric (<18 years) review literature. Studies reporting gut microbiome composition and/or biotic supplementation on depression, bipolar disorder, anxiety, attention deficit hyperactivity disorder, autism spectrum disorder (ASD), or obsessive-compulsive disorder (OCD) were included. Deduplication and screening took place in Covidence. A sensitivity analysis was conducted to assess the degree of primary study overlap. Among the 39 included review studies, 23 (59%) were observational and 16 (41%) were interventional. Most reviews (92%) focused on ASD. Over half (56%) of the observational and interventional reviews scored low or critically low for methodological quality. A higher abundance of Clostridium clusters and a lower abundance of Bifidobacterium were consistently observed in ASD studies. Biotic supplementation was associated with ASD symptom improvement. Gut microbiome-mental health evidence syntheses in child and youth depression, anxiety, bipolar disorder, and OCD are lacking. Preliminary evidence suggests an association between specific microbiota and ASD symptoms, with some evidence supporting a role for probiotic supplementation ASD therapy.
Where to start? Exploring how sustainable startups integrate sustainability impact assessment within their entrepreneurial process
Authors: Carle Alice , Rayna Thierry
Published: September 2023

While startups are acknowledged for their potential to address sustainability issues, little is known on how to assess their impact, given the uncertainty they deal with and their lack of resources. This paper investigates the ones that are supposed to be ‘best-in-class’ in that matter, that is, startups targeting sustainability, in order to explore how they integrate sustainability impact assessment in their entrepreneurial process. We conducted a multiple case study of eight sustainable startups, based on a 2-year longitudinal research in their incubator to gather multiple sources of information. Our results revealed that the integration of the triple bottom line in the entrepreneurial process has a major effect on startups’ sustainability impact assessment practices. ‘Born-sustainable startups’, which have aimed for the triple bottom line since idea generation, have more robust tools and routines than ‘Transitioned sustainable startups’, which integrated the triple bottom line during prototype/validation.
La conexión entre ambientes de tierras bajas y altas en el límite Cuyo Patagonia (Argentina): Un análisis sobre el transporte y uso de obsidiana Laguna del Maule
Authors: Salgán María Laura , Pompei M. Paz , Gil Adolfo , Neme Gustavo , Sruoga Patricia , Glascock Michael D.
Published: September 2023

Este trabajo busca conocer las estrategias tecnológicas, los rangos de acción y la conectividad en las estrategias humanas de ambientes marginales. Se discute, para el caso del sur de Mendoza, el modelo clásico de trashumancia cazadora recolectora entre tierras bajas y altas. El estudio se centra específicamente en El Payén y en el uso de la obsidiana andina Laguna del Maule. En El Payén, esta obsidiana ocupa el primer lugar entre las variedades conocidas y su uso se vinculó a circuitos de movilidad estacional que involucraban tierras bajas y altas. La obsidiana Laguna del Maule posee dos subtipos geoquímicos, el Subtipo 1 registrado en cordillera, y el Subtipo 2 localizado en depósitos fluviales distales. En este trabajo modelamos las estrategias de interacción de tierras altas con tierras bajas, enfocándonos en modelos propuestos para La Payunia, que ponen énfasis en la tecnología lítica y se articulan con análisis geoquímicos y geoarqueológicos. Los resultados sostienen que las poblaciones de El Payén obtenían este recurso mediante distintas estrategias tecnológicas: un aprovisionamiento serial del Subtipo 2, con circuitos de movilidad centrados en tierras bajas; diferente al Subtipo 1 de aprovisionamiento cíclico, que habría involucrado la interacción entre tierras altas y tierras bajas.
Efficacy and safety of n-3 fatty acids supplementation on depression: a systematic review and dose–response meta-analysis of randomised controlled trials
Authors: Norouziasl Reyhane , Zeraattalab-Motlagh Sheida , Jayedi Ahmad , Shab-Bidar Sakineh
Published: September 2023

We aimed to investigate the effectiveness of n-3 fatty acids supplementation on the risk of developing depression, depressive symptoms and remission of depression. We searched PubMed, Scopus and Web of Science from inception to December 2022 to find randomised trials of n-3 fatty acids supplementation in adults. We conducted random-effects meta-analyses to estimate standardised mean differences (SMD) and 95 % CI for continuous outcomes and risk difference and 95 % CI for binary outcomes. A total of sixty-seven trials were included. Each 1 g/d n-3 fatty acids supplementation significantly improved depressive symptoms in adults with and without depression (moderate-certainty evidence), with a larger improvement in patients with existing depression. Dose–response analyses indicated a U-shaped effect in patients with existing depression, with the greatest improvement at 1·5 g/d. The analysis showed that n-3 fatty acid supplementation significantly increased depression remission by 19 more per 100 in patients with depression (low-certainty evidence). Supplementation with n-3 fatty acids did not reduce the risk of developing depression among the general population, but it did improve the severity of depression among patients with existing depression.
The Anti-Father and His Silent Sons: Disability, Healing, and Critique in the Acts of John
Authors: Crabbe Kylie
Published: September 2023

This article analyzes the second-century Acts of John 56–57, in which Antipatros seeks healing for his twin sons whom he claims he cannot support as he ages. I argue that this passage turns on a layered critique of Antipatros. First, the text censures medical commerce. Second, it uses his threat of murder, economic circumstances, and name to undermine Antipatros as both father and inquiring disciple. The episode thus leverages criticism of a character whose negative attitudes lead him to contemplate destruction of those with infirmities. However, it retains a mixed message: while the character of the apostle John comes to focus on the sons, the narrative silences them. Ultimately, the text emphasizes what the critique means for the flawed male, elite father, rather than the experience of the impaired sons. Such dynamics warrant close attention as we continue to expand our understanding of attitudes to disability in sources from antiquity.
Free Speech in the Civil War
Authors: BRETTLE ADRIAN
Published: September 2023

During the Civil War, many Americans were prepared for censorship if free speech undermined preserving the Union. Journalists were unable to obtain timely accurate information on the military campaigns either for fear of helping the enemy or depressing morale at home. Self-censorship was far more important than official suppression of free speech, as spontaneous popular pressure curtailed freedom of expression at the beginning of the war and later on the army performed a similar function. For Federals, commitment to preserving the Union required treating Confederates as ubiquitous seditious conspirators. Combatting this internal enemy, in turn, especially in the Border States, required extensive suppression of free speech. Later in the conflict and right across the Union, the critical and urgent need to fill the ranks led to official censorship of any words that might discourage volunteering, and this conflicted with freedom of religion as well as speech and the press.
Parental recommendations and exercise attitudes in congenital hearts
Authors: Wadey Curtis A. , Leggat Fiona J. , Potter Julia , Amir Nurul H. , Forsythe Lynsey , Stuart A. Graham , Barker Alan R. , Williams Craig A.
Published: September 2023

Background:

Children and young people with CHD benefit from regular physical activity. Parents are reported as facilitators and barriers to their children’s physical activity. The aim of this study was to explore parental factors, child factors, and their clinical experience on physical activity participation in young people with CHD.

Methods:

An online questionnaire was co-developed with parents (n = 3) who have children with CHD. The survey was then distributed in the United Kingdom by social media and CHD networks, between October 2021 and February 2022. Data were analysed using mixed methods.

Results:

Eighty-three parents/guardians responded (94% mothers). Young people with CHD were 7.3 ± 5.0 years old (range 0–20 years; 53% female) and 84% performed activity. Parental participation in activity (X2(1) = 6.9, P < 0.05) and perceiving activity as important for their child were positively associated with activity (Fisher’s Exact, P < 0.05). Some parents (∼15%) were unsure of the safety of activity, and most (∼70%) were unsure where to access further information about activity. Fifty-two parents (72%) had never received activity advice in clinic, and of the 20 who received advice, 10 said it was inconsistent. Qualitative analysis produced the theme “Knowledge is power and comfort.” Parents described not knowing what activity was appropriate or the impact of it on their child.

Conclusion:

Parental participation and attitudes towards activity potentially influence their child’s activity. A large proportion of young people performed activity despite a lack and inconsistency of activity advice offered by CHD clinics. Young people with CHD would benefit from activity advice with their families in clinics.
An examination of willingness to participate and willingness to pay for a universal school food program in the Canadian context
Authors: Datta Gupta Suvadra , Pahwa Punam , Engler-Stringer Rachel
Published: September 2023

Objective:

To examine parents’/caregivers’ willingness to participate and willingness to pay (WTP) for a cost-shared school food program (SFP) and its associated factors.

Design:

A quantitative survey design was used where WTP for a hypothetical SFP was elicited using a double-bounded dichotomous choice elicitation method. We used a double hurdle (logistic and truncated regression) model to examine WTP and positively or negatively associated factors.

Setting:

Saskatoon Public School Division elementary schools situated in high-, mid- or low-median-income neighbourhoods.

Participants:

Parents or caregivers of children attending grades 1 to grade 8 in the Saskatoon Public School Division elementary schools.

Results:

94 % respondents were willing to participate in a SFP while less than two-thirds of participants were willing to pay for such a program. Over 90 % respondents from all the socio-economic groups were willing to participate. Multiple household income earners, higher household income, higher number of children, household food security status and higher academic attainment of parents’/caregivers predicted greater willingness to pay. Mean willingness to pay was $4·68 (CAN), and households reporting moderate or severe food insecurity were likely to be willing to pay significantly less for a SFP.

Conclusion:

A cost-shared program might be financially sustainable in Canada if community characteristics such as household food insecurity status, economic participation of women and average household size are kept in mind while determining the price of the program.
Comment on “Seismic Velocity Variations at Different Depths Reveal the Dynamic Evolution Associated With the 2018 Kilauea Eruption” by Liu et al.
Authors: Wei XiaoZhuo , Shen Yang
Published: September 2023

Liu et al. (2022, https://doi.org/10.1029/2021GL093691) used Rayleigh waves extracted from the cross‐correlation of ambient noise recorded by two stations to monitor the seismic velocity variations associated with the 2018 Kı̄lauea eruption. However, their study ignored the fact that the tremors on the Island of Hawai'i were dominated by a source at the Kı̄lauea summit before the eruption. Close inspection of the waveforms of the station pair PAUD‐STCD shows a simple, mistakenly identified wave traveling direction in Liu et al. (2022, https://doi.org/10.1029/2021GL093691). A correct wave traveling direction agrees with the noise source model, where the dominant tremor source should be at the Kı̄lauea summit. Because of the drastic change in the tremor source after the eruption, the cross‐correlation of the tremor records may reflect predominantly changes in the source rather than in the medium properties between the two stations.
TGE Electron Energy Spectra: Comment on “Radar Diagnosis of the Thundercloud Electron Accelerator” by E. Williams et al. (2022)
Authors: Chilingarian A. , Hovsepyan G. , Aslanyan D. , Karapetyan T. , Sargsyan B. , Zazyan M.
Published: September 2023

E. Williams et al. (2022, commented paper) questioned electron energy spectra derived from thunderstorm ground enhancements (TGEs) measured on Aragats; they concluded that “A more likely origin for any detected electrons at 3.2 km above sea level is Compton scattering and pair production activated by longer‐range bremsstrahlung gamma rays, themselves produced by runaway electron encounters with nuclei in the breakeven field at higher altitude.” In this comment, we show that the selection criteria of “electron” TGEs unambiguously reject the assumption of the origination of TGE electrons measured on Aragats from the Compton and pair production processes. Thus, the strong accelerating electric field above the earth's surface can be significantly lower (25–150 m) than derived in the commented paper 500 m altitude.
The Role of Stratified Turbulence in the Cold Summer Mesopause Region
Authors: Avsarkisov Victor , Conte J. Federico
Published: September 2023

The summer mesopause at middle and high latitudes is the coldest place on Earth, and atmospheric gravity waves are responsible for the emergence of this extreme thermal phenomenon. Although the main physical mechanism behind the latter is understood, a deeper insight into it can be gained from the investigation of the mesoscale energy spectrum. In this work, we decompose the frequency spectra into divergent and rotational parts and find that their energy contributions are equipartitioned at high frequencies. This mesoscale energy equipartition is a feature of stratified turbulence and illustrates the complexity of the mesoscale dynamics in the summer mesopause region. We also analyze the power spectra of observed and simulated mesoscale zonal and meridional winds at middle latitudes in the Southern Hemisphere and show that stratified turbulence plays a role in the mesopause region during summer.
Melt Network Reorientation and Crystallographic Preferred Orientation Development in Sheared Partially Molten Rocks
Authors: Seltzer Cassandra , Peč Matěj , Zimmerman Mark E. , Kohlstedt David L.
Published: September 2023

We investigated the co‐evolution of melt, shape, and crystallographic preferred orientations (MPOs, SPOs, and CPOs) in experimentally deformed partially molten rocks, from which we calculated the influence of MPO and CPO on seismic anisotropy. Olivine‐basalt aggregates containing 2 to 4 wt% melt were deformed in general shear at a temperature of 1,250°C under a confining pressure of 300 MPa at shear stresses of τ ≤ 175 MPa to shear strains of γ ≤ 2.3. Grain‐scale melt pockets developed a MPO parallel to the loading direction by γ < 0.4. At higher strains, the grain‐scale MPO remained parallel to the loading direction, while incipient sample‐scale melt bands formed at ∼20° to the grain‐scale MPO. An initial SPO and CPO were induced during sample preparation, with [100] and [001] axes girdled perpendicular to the long axis of the starting material. At the highest explored strain, a strong SPO was established subperpendicular to the loading direction, and the [100] axes of the CPO clustered nearly parallel to the shear plane. Our results demonstrate that grain‐scale and sample‐scale alignments of melt pockets are distinct. Furthermore, the melt and the solid microstructures evolve on different timescales: in planetary bodies, changes in the stress field will drive a relatively fast reorientation of the melt network and a relatively slow realignment of the crystallographic axes. Rapid changes to seismic anisotropy in a deforming partially molten aggregate are thus caused by MPO rather than CPO.
Seasonal Prediction of Arabian Sea Marine Heatwaves
Authors: Koul Vimal , Brune Sebastian , Akimova Anna , Düsterhus André , Pieper Patrick , Hövel Laura , Parekh Anant , Schrum Corinna , Baehr Johanna
Published: September 2023

Marine heatwaves are known to have a detrimental impact on marine ecosystems, yet predicting when and where they will occur remains a challenge. Here, using a large ensemble of initialized predictions from an Earth System Model, we demonstrate skill in predictions of summer marine heatwaves over large marine ecosystems in the Arabian Sea seven months ahead. Retrospective forecasts of summer (June to August) marine heatwaves initialized in the preceding winter (November) outperform predictions based on observed frequencies. These predictions benefit from initialization during winters of medium to strong El Niño conditions, which have an impact on marine heatwave characteristics in the Arabian Sea. Our probabilistic predictions target spatial characteristics of marine heatwaves that are specifically useful for fisheries management, as we demonstrate using an example of Indian oil sardine (Sardinella longiceps).
Continental Thermal Structure and Carbonate Storage of Subducted Sedimentary Origin Control on Different Increases in Atmospheric CO2 in Late Ediacaran and Jurassic
Authors: Wang Xinxin , Zhao Liang , Yang Jianfeng , Li Jilei , Chen Ling , Sun Baolu
Published: September 2023

Carbon release during continental rifting is thought to regulate atmospheric CO2 levels. Supercontinent dispersal‐induced extensional tectonics is similar during the Late Ediacaran and Jurassic, while they exhibit different increases in atmospheric CO2 concentration. The underlying mechanism of distinct CO2 emissions remains to be understood. Here, we conduct petrological‐thermomechanical modeling to show that metamorphic decarbonation and melting of carbonates that are derived from subducted sediments are ubiquitous during continental extension. We find that the hotter lithosphere and deeper storage of these carbonates cause more significant amounts of rift‐related CO2 release through volcanoes and faults. They may cause ∼12%–77% larger decarbonation efficiency, providing an efficient driving mechanism for a ∼31% larger increase in atmospheric CO2 levels during the Late Ediacaran than throughout the Jurassic. The rapid eruption and deposition of recycled carbonatite volcanic ash may contribute to the production of Late Ediacaran marine carbonates with the largest negative δ13C (−12‰).
Geophysically Informed Machine Learning for Improving Rapid Estimation and Short‐Term Prediction of Earth Orientation Parameters
Authors: Kiani Shahvandi Mostafa , Dill Robert , Dobslaw Henryk , Kehm Alexander , Bloßfeld Mathis , Schartner Matthias , Mishra Siddhartha , Soja Benedikt
Published: September 2023

Rapid provision of Earth orientation parameters (EOPs, here polar motion and dUT1) is indispensable in many geodetic applications and also for spacecraft navigation. There are, however, discrepancies between the rapid EOPs and the final EOPs that have a higher latency but the highest accuracy. To reduce these discrepancies, we focus on a data‐driven approach, present a novel method named ResLearner, and use it in the context of deep ensemble learning. Furthermore, we introduce a geophysically constrained approach for ResLearner. We show that the most important geophysical information to improve the rapid EOPs is the effective angular momentum functions of atmosphere, ocean, land hydrology, and sea level. In addition, semidiurnal, diurnal, and long‐period tides coupled with prograde and retrograde tidal excitations are important features. The influence of some climatic indices on the prediction accuracy of dUT1 is discussed, and El Niño Southern Oscillation is found to be influential. We developed an operational framework, providing the improved EOPs on a daily basis with a prediction window of 63 days to fully cover the latency of final EOPs. We show that under the operational conditions and using the rapid EOPs of the International Earth Rotation and Reference Systems Service (IERS), we achieve improvements as high as 60%, thus significantly reducing the differences between rapid and final EOPs. Furthermore, we discuss how the new final series IERS 20 C04 is preferred over 14 C04. Finally, we compare against EOP hindcast experiments of the European Space Agency, on which ResLearner presents comparable improvements.
Influences of Lateral Boundary Forcings on the 2020 Extreme Meiyu in the Yangtze‐Huaihe River Valley
Authors: Zhu Xiaoyu , Hu Yijia , Sun Xuguang , Zhong Zhong , Ha Yao , Li Yunying
Published: September 2023

Meiyu occurs in Yangtze‐Huaihe River valley (YHRV) every summer. Its intensity, distribution, and intraseasonal variation are greatly influenced by atmospheric forcings from different directions, such as the monsoon southwesterlies from the south, the western Pacific subtropical high (WPSH) in the east, the atmospheric longwave activities in the north, the southwest vortex from the west, and so on. In this study, to explore the contributions of the atmospheric forcings from different directions to 2020 extreme Meiyu, Regional Climate Model version 4.6 (RegCM4.6) is employed. A series of sensitivity experiments are conducted with realistic or climatological averaged lateral boundary conditions. The results show that the monsoon westerlies from the south transport moisture and heat to YHRV, converge with the cold air brought by the frequent atmospheric longwave activities in the north, and result in this extreme Meiyu. The frequent cold air from the north can lift warm air, provide unstable conditions, and make the distribution of precipitation similar to the teleconnection pattern in East Asia. The stable WPSH in the east anchors the 2020 Meiyu rainband to the YHTV for a long time. In addition, the contributions of the atmospheric forcings from different directions to evolution of 2020 Meiyu change with time. Before 10 June, the WPSH in the east mainly contributes to the Meiyu evolution. From 11 June to 3 July, the combined effects of atmospheric forcings from the south and north are dominant. From 3 July to 10 July, the cold air from the north plays a major role.
The PFC-LH-VTA pathway contributes to social deficits in IRSp53-mutant mice
Authors: Noh Young Woo , Kim Yangsik , Lee Soowon , Kim Yeonghyeon , Shin Jae Jin , Kang Hyojin , Kim Il Hwan , Kim Eunjoon
Published: September 2023

Dopamine (DA) neurons in the ventral tegmental area (VTA) promote social brain functions by releasing DA onto nucleus accumbens neurons, but it remains unclear how VTA neurons communicate with cortical neurons. Here, we report that the medial prefrontal cortex (mPFC)-lateral hypothalamus (LH)-VTA pathway contributes to social deficits in mice with IRSp53 deletion restricted to cortical excitatory neurons (Emx1-Cre;Irsp53fl/fl mice). LH-projecting mutant mPFC neurons display abnormally increased excitability involving decreased potassium channel gene expression, leading to excessive excitatory synaptic input to LH-GABA neurons. A circuit-specific IRSp53 deletion in LH-projecting mPFC neurons also increases neuronal excitability and induces social deficits. LH-GABA neurons with excessive mPFC excitatory synaptic input show a compensatory decrease in excitability, weakening the inhibitory LHGABA-VTAGABA pathway and subsequently over-activating VTA-GABA neurons and over-inhibiting VTA-DA neurons. Accordingly, optogenetic activation of the LHGABA-VTAGABA pathway improves social deficits in Emx1-Cre;Irsp53fl/fl mice. Therefore, the mPFC-LHGABA-VTAGABA-VTADA pathway contributes to the social deficits in Emx1-Cre;Irsp53fl/fl mice.
A first-in-human phase 1 study of nofazinlimab, an anti-PD-1 antibody, in advanced solid tumors and in combination with regorafenib in metastatic colorectal cancer
Authors: Day Daphne , Park John J. , Coward Jermaine , Markman Ben , Lemech Charlotte , Kuo James C. , Prawira Amy , Brown Michael P. , Bishnoi Sarwan , Kotasek Dusan , Strother R. Matthew , Cosman Rasha , Su Rila , Ma Yiding , Yue Zenglian , Hu Hui-han , Wu Rachel , Li Peiqi , Tse Archie N.
Published: September 2023

Background

We assessed nofazinlimab, an anti-PD-1 antibody, in solid tumors and combined with regorafenib in metastatic colorectal cancer (mCRC).

Methods

This phase 1 study comprised nofazinlimab dose escalation (phase 1a) and expansion (phase 1b), and regorafenib dose escalation (80 or 120 mg QD, days 1–21 of 28-day cycles) combined with 300-mg nofazinlimab Q4W (part 2a) to determine safety, efficacy, and RP2D.

Results

In phase 1a (N = 21), no dose-limiting toxicity occurred from 1 to 10 mg/kg Q3W, with 200 mg Q3W determined as the monotherapy RP2D. In phase 1b (N = 87), 400-mg Q6W and 200-mg Q3W regimens were found comparable. In part 2a (N = 14), both regimens were deemed plausible RP2Ds. Fatigue was the most frequent treatment-emergent adverse event (AE) in this study. Any-grade and grade 3/4 nofazinlimab-related AEs were 71.4% and 14.3%, 56.3% and 5.7%, and 57.1% and 21.4% in phases 1a, 1b, and part 2a, respectively. ORRs were 14.3% and 25.3% in phases 1a and 1b, respectively. In part 2a, no patients had radiological responses.

Conclusions

Nofazinlimab monotherapy was well tolerated and demonstrated preliminary anti-tumor activity in multiple tumor types. Regorafenib plus nofazinlimab had a manageable safety profile but was not associated with any response in mCRC.

Clinical trial registr ation

Clinicaltrials.gov (NCT03475251).
SCF and IL-33 regulate mouse mast cell phenotypic and functional plasticity supporting a pro-inflammatory microenvironment
Authors: Molfetta Rosa , Lecce Mario , Milito Nadia D. , Putro Erisa , Pietropaolo Giuseppe , Marangio Caterina , Scarno Gianluca , Moretti Marta , De Smaele Enrico , Santini Tiziana , Bernardini Giovanni , Sciumè Giuseppe , Santoni Angela , Paolini Rossella
Published: September 2023

Mast cells (MCs) are multifaceted innate immune cells often present in the tumor microenvironment (TME). Several recent findings support their contribution to the transition from chronic inflammation to cancer. However, MC-derived mediators can either favor tumor progression, inducing the spread of the tumor, or exert anti-tumorigenic functions, limiting tumor growth. This apparent controversial role likely depends on the plastic nature of MCs that under different microenvironmental stimuli can rapidly change their phenotype and functions. Thus, the exact effect of unique MC subset(s) during tumor progression is far from being understood. Using a murine model of colitis-associated colorectal cancer, we initially characterized the MC population within the TME and in non-lesional colonic areas, by multicolor flow cytometry and confocal microscopy. Our results demonstrated that tumor-associated MCs harbor a main connective tissue phenotype and release high amounts of Interleukin (IL)-6 and Tumor Necrosis Factor (TNF)-α. This MC phenotype correlates with the presence of high levels of Stem Cell Factor (SCF) and IL-33 inside the tumor. Thus, we investigated the effect of SCF and IL-33 on primary MC cultures and underscored their ability to shape MC phenotype eliciting the production of pro-inflammatory cytokines. Our findings support the conclusion that during colonic transformation a sustained stimulation by SCF and IL-33 promotes the accumulation of a prevalent connective tissue-like MC subset that through the secretion of IL-6 and TNF-α maintains a pro-inflammatory microenvironment.
Upper-plate conduits linked to plate boundary that hosts slow earthquakes
Authors: Arai Ryuta , Miura Seiichi , Nakamura Yasuyuki , Fujie Gou , Kodaira Shuichi , Kaiho Yuka , Mochizuki Kimihiro , Nakata Rie , Kinoshita Masataka , Hashimoto Yoshitaka , Hamada Yohei , Okino Kyoko
Published: September 2023

In shallow subduction zones, fluid behavior impacts various geodynamic processes capable of regulating slip behaviors and forming mud volcanoes. However, evidence of structures that control the fluid transfer within an overriding plate is limited and the physical properties at the source faults of slow earthquakes are poorly understood. Here we present high-resolution seismic velocity models and reflection images of the Hyuga-nada area, Japan, where the Kyushu-Palau ridge subducts. We image distinct kilometer-wide columns in the upper plate with reduced velocities that extend vertically from the seafloor down to 10–13 km depth. We interpret the low-velocity columns as damaged zones caused by seamount subduction and suggest that they serve as conduits, facilitating vertical fluid migration from the plate boundary. The lateral variation in upper-plate velocity and seismic reflectivity along the plate boundary correlates with the distribution of slow earthquakes, indicating that the upper-plate drainage system controls the complex pattern of seismic slip at subduction faults.
Genetic reversal of the globin switch concurrently modulates both fetal and sickle hemoglobin and reduces red cell sickling
Authors: De Souza Daniel C. , Hebert Nicolas , Esrick Erica B. , Ciuculescu M. Felicia , Archer Natasha M. , Armant Myriam , Audureau Étienne , Brendel Christian , Di Caprio Giuseppe , Galactéros Frédéric , Liu Donghui , McCabe Amanda , Morris Emily , Schonbrun Ethan , Williams Dillon , Wood David K. , Williams David A. , Bartolucci Pablo , Higgins John M.
Published: September 2023

We previously reported initial clinical results of post-transcriptional gene silencing of BCL11A expression (NCT 03282656) reversing the fetal to adult hemoglobin switch. A goal of this approach is to increase fetal hemoglobin (HbF) expression while coordinately reducing sickle hemoglobin (HbS) expression. The resulting combinatorial effect should prove effective in inhibiting HbS polymerization at lower physiologic oxygen values thereby mitigating disease complications. Here we report results of exploratory single-cell analysis of patients in which BCL11A is targeted molecularly and compare results with cells of patients treated with hydroxyurea (HU), the current standard of care. We use single-cell assays to assess HbF, HbS, oxygen saturation, and hemoglobin polymer content in RBCs for nine gene therapy trial subjects (BCLshmiR, median HbF% = 27.9) and compare them to 10 HU-treated subjects demonstrating high and comparable levels of HbF (HU High Responders, median HbF% = 27.0). All BCL11A patients achieved the primary endpoint for NCT 03282656, which was defined by an absolute neutrophil count greater than or equal to 0.5 × 109 cells/L for three consecutive days, achieved within 7 weeks following infusion. Flow cytometric assessment of single-RBC HbF and HbS shows fewer RBCs with high HbS% that would be most susceptible to sickling in BCLshmiR vs. HU High Responders: median 42% of RBCs with HbS%>70% in BCLshmiR vs. 61% in HU High Responders (p = 0.004). BCLshmiR subjects also demonstrate more RBCs resistant to HbS polymerization at lower physiologic oxygen tension: median 32% vs. 25% in HU High Responders (p = 0.006). Gene therapy-induced BCL11A down-regulation reverses the fetal-to-adult hemoglobin switch and induces RBCs with higher HbF%, lower HbS%, and greater resistance to deoxygenation-induced polymerization in clinical trial subjects compared with a cohort of highly responsive hydroxyurea-treated subjects.
Conserved roles for the dynein intermediate chain and Ndel1 in assembly and activation of dynein
Authors: Okada Kyoko , Iyer Bharat R. , Lammers Lindsay G. , Gutierrez Pedro A. , Li Wenzhe , Markus Steven M. , McKenney Richard J.
Published: September 2023

Processive transport by the microtubule motor cytoplasmic dynein requires the regulated assembly of a dynein-dynactin-adapter complex. Interactions between dynein and dynactin were initially ascribed to the dynein intermediate chain N-terminus and the dynactin subunit p150Glued. However, recent cryo-EM structures have not resolved this interaction, questioning its importance. The intermediate chain also interacts with Nde1/Ndel1, which compete with p150Glued for binding. We reveal that the intermediate chain N-terminus is a critical evolutionarily conserved hub that interacts with dynactin and Ndel1, the latter of which recruits LIS1 to drive complex assembly. In additon to revealing that the intermediate chain N-terminus is likely bound to p150Glued in active transport complexes, our data support a model whereby Ndel1-LIS1 must dissociate prior to LIS1 being handed off to dynein in temporally discrete steps. Our work reveals previously unknown steps in the dynein activation pathway, and provide insight into the integrated activities of LIS1/Ndel1 and dynactin/cargo-adapters.
Predictors of the post-COVID condition following mild SARS-CoV-2 infection
Authors: Reme B-A. , Gjesvik J. , Magnusson K.
Published: September 2023

Whereas the nature of the post-COVID condition following mild acute COVID-19 is increasingly well described in the literature, knowledge of its risk factors, and whether it can be predicted, remains limited. This study, conducted in Norway, uses individual-level register data from 214,667 SARS-CoV-2 infected individuals covering a range of demographic, socioeconomic factors, as well as cause-specific healthcare utilization in the years prior to infection to assess the risk of post-COVID complaints ≥3 months after testing positive. We find that the risk of post-COVID was higher among individuals who prior to infection had been diagnosed with psychological (OR = 2.12, 95% CI 1.84–2.44), respiratory (OR = 2.03, 95% CI 1.78–2.32), or general and unspecified health problems (OR = 1.78, 95% CI 1.52–2.09). To assess the predictability of post-COVID after mild initial disease, we use machine learning methods and find that pre-infection characteristics, combined with information on the SARS-CoV-2 virus type and vaccine status, to a considerable extent (AUC = 0.79, 95% CI 0.75–0.81) could predict the occurrence of post-COVID complaints in our sample.
Genome-wide probing of eukaryotic nascent RNA structure elucidates cotranscriptional folding and its antimutagenic effect
Authors: Yu Gongwang , Liu Yao , Li Zizhang , Deng Shuyun , Wu Zhuoxing , Zhang Xiaoyu , Chen Wenbo , Yang Junnan , Chen Xiaoshu , Yang Jian-Rong
Published: September 2023

The transcriptional intermediates of RNAs fold into secondary structures with multiple regulatory roles, yet the details of such cotranscriptional RNA folding are largely unresolved in eukaryotes. Here, we present eSPET-seq (Structural Probing of Elongating Transcripts in eukaryotes), a method to assess the cotranscriptional RNA folding in Saccharomyces cerevisiae. Our study reveals pervasive structural transitions during cotranscriptional folding and overall structural similarities between nascent and mature RNAs. Furthermore, a combined analysis with genome-wide R-loop and mutation rate approximations provides quantitative evidence for the antimutator effect of nascent RNA folding through competitive inhibition of the R-loops, known to facilitate transcription-associated mutagenesis. Taken together, we present an experimental evaluation of cotranscriptional folding in eukaryotes and demonstrate the antimutator effect of nascent RNA folding. These results suggest genome-wide coupling between the processing and transmission of genetic information through RNA folding.
Metal-organic framework template-guided electrochemical lithography on substrates for SERS sensing applications
Authors: Lu Youyou , Zhang Xuan , Zhao Liyan , Liu Hong , Yan Mi , Zhang Xiaochen , Mochizuki Kenji , Yang Shikuan
Published: September 2023

The templating method holds great promise for fabricating surface nanopatterns. To enhance the manufacturing capabilities of complex surface nanopatterns, it is important to explore new modes of the templates beyond their conventional masking and molding modes. Here, we employed the metal-organic framework (MOF) microparticles assembled monolayer films as templates for metal electrodeposition and revealed a previously unidentified guiding growth mode enabling the precise growth of metallic films exclusively underneath the MOF microparticles. The guiding growth mode was induced by the fast ion transportation within the nanochannels of the MOF templates. The MOF template could be repeatedly used, allowing for the creation of identical metallic surface nanopatterns for multiple times on different substrates. The MOF template-guided electrochemical growth mode provided a robust route towards cost-effective fabrication of complex metallic surface nanopatterns with promising applications in metamaterials, plasmonics, and surface-enhanced Raman spectroscopy (SERS) sensing fields.
Efficiently accelerated free electrons by metallic laser accelerator
Authors: Zheng Dingguo , Huang Siyuan , Li Jun , Tian Yuan , Zhang Yongzhao , Li Zhongwen , Tian Huanfang , Yang Huaixin , Li Jianqi
Published: September 2023

Strong electron-photon interactions occurring in a dielectric laser accelerator provide the potential for development of a compact electron accelerator. Theoretically, metallic materials exhibiting notable surface plasmon-field enhancements can possibly generate a high electron acceleration capability. Here, we present a design for metallic material-based on-chip laser-driven accelerators that show a remarkable electron acceleration capability, as demonstrated in ultrafast electron microscopy investigations. Under phase-matching conditions, efficient and continuous acceleration of free electrons on a periodic nanostructure can be achieved. Importantly, an asymmetric spectral structure in which the vast majority of the electrons are in the energy-gain states has been obtained by means of a periodic bowtie-structure accelerator. Due to the presence of surface plasmon enhancement and nonlinear optical effects, the maximum acceleration gradient can reach as high as 0.335 GeV/m. This demonstrates that metallic laser accelerator could provide a way to develop compact accelerators on chip.