bluuebunny/crossref_metadata_2025 huggingface dataset:
Motivation to Lead as Mediator of Relations Between the Dark Triad, Big Five, and Leadership Intention
Authors: Kennedy Jeffrey C. , Chan Kim Yin , Ho Moon-Ho Ringo , Uy Marilyn A. , Chernyshenko Oleksander S.
Published: August 2021

This study seeks to enhance the distal-proximal modeling of personality trait–leader emergence relationships by (1) distinguishing between the motivation to lead (i.e., the reasons why a person seeks leadership roles) and leadership intention (i.e., one’s expressed desire to claim a leadership role) and by (2) examining how the Dark Triad traits add to the Big Five personality factors in predicting three motivation to lead factors and leadership intentions. Using personality and careers aspiration data collected from 750 university students, we found that affective-identity and social-normative motivation to lead mediate the effects of distal traits on intentions. In contrast, non-calculative motivation to lead does not contribute to leadership intentions, which has important implications for organizations seeking selfless leaders. Narcissism explains variance in leadership intentions over and above that explained by extraversion; this contrasts with the studies of leader emergence, where the effect of narcissism disappears once extraversion is controlled. Overall, our findings validate the three-factor conceptualization of motivation to lead and illuminate the roles of both bright and dark personality factors in understanding individual desire to attain leadership roles.
Concealing Untrustworthiness: The Role of Conflict Monitoring in a Social Deception Task
Authors: Hein Fee-Elisabeth , Leue Anja
Published: August 2021

Deception studies emphasize the important role of event-related potentials (ERPs) to uncover deceptive behavior based on underlying neuro-cognitive processes. The role of conflict monitoring as indicated by the frontal N2 component during truthful and deceptive responses was investigated in an adapted Concealed Information Test (CIT). Previously memorized pictures of faces should either be indicated as truthfully trustworthy, truthfully untrustworthy or trustworthy while concealing the actual untrustworthiness (untrustworthy-probe). Mean, baseline-to-peak and peak-to-peak amplitudes were calculated to examine the robustness of ERP findings across varying quantification techniques. Data of 30 participants (15 female; age: M = 23.73 years, SD = 4.09) revealed longer response times and lower correct rates for deceptive compared to truthful trustworthy responses. The frontal N2 amplitude was more negative for untrustworthy-probe and truthful untrustworthy compared to truthful trustworthy stimuli when measured as mean or baseline-to-peak amplitude. Results suggest that deception evokes conflict monitoring and ERP quantifications are differentially sensitive to a-priori hypotheses.
Validation of the French Version of the Child Posttraumatic Stress Checklist in French School-Aged Children
Authors: Gindt Morgane , Richez Aurelien , Battista Michèle , Fabre Roxane , Thümmler Susanne , Fernandez Arnaud , Askenazy Florence
Published: August 2021

Background: The child posttraumatic stress disorder checklist (CPC) updated to DSM-5 is a questionnaire aimed to assess posttraumatic stress disorder (PTSD) symptoms in children. It is available in both parents and child versions. The back-translation method has been used for the French translation of the CPC. It has not been yet validated in French-speaking populations. The aim of this study was to assess the psychometric properties and the validity of the CPC in a sample of French-speaking schoolchildren and their parents.

Methods: The sample was composed by 176 children outpatients implicated in the Nice terrorist attack (14 July 2016) aged 7–17 (mean = 11.68 years, SD = 2.63 months) and 122 parents. Cronbach's alpha was used to test CPC internal consistency. The Spearman-correlation coefficient was performed between the French version of the CPC and the Kiddie Schedule for Affective Disorders and Schizophrenia Present and Lifetime version (K-SADS-PL) to assess the convergent validity. An ROC curve was constructed to verify the validity of the cutoff scores. An evaluation of the sensitivity and specificity of each score and a comparison with the diagnosis of the K-SADS-PL were made. Finally, a principal component analysis with varimax rotation was computed to analyze the structure of the French version of the CPC.

Results: Cronbach's alpha coefficient was 0.90 for child version and 0.91 for parent version of the CPC. There was a statistical correlation between the K-SADS-PL for PTSD and the total score of CPC for the child version (r = 0.62; p < 0.001) and for the parent version (r = 0.55; p < 0.001). The sensitivity and specificity of the children version with a threshold of >20 were 73.1 and 84.7%, respectively, using the K-SADS-PL as the diagnostic reference for PTSD. Concerning the parent version, using the same recommended cutoff score, the sensitivity, and specificity were 77 and 80.5%, respectively.

Conclusions: The psychometric properties of the French CPC are good. This questionnaire appears to be valid and should be used in French-speaking children.
The European Union and Public Health Emergencies: Expert Opinions on the Management of the First Wave of the COVID-19 Pandemic and Suggestions for Future Emergencies
Authors: Gontariuk Marie , Krafft Thomas , Rehbock Cassandra , Townend David , Van der Auwermeulen Loth , Pilot Eva
Published: August 2021

Objective: The first wave of the coronavirus SARS-COV-2 pandemic has revealed a fragmented governance within the European Union (EU) to tackle public health emergencies. This qualitative study aims: 1) to understand the current EU position within the field of public health emergencies taking the case of the COVID-19 as an example by comparing and contrasting experiences from EU institutions and experts from various EU Member States at the beginning of the pandemic; and, 2) to identify and to formulate future EU pandemic strategies and actions based on experts' opinions.

Methods: Eighteen semi-structured interviews were conducted with public health experts from various European Member States and European Commission officials from May 2020 until August 2020. The transcripts were analyzed by Thematic Content Analysis (TCA), mainly a manifest content analysis.

Results: This study demonstrated that the limited EU mandate in health hinders proper actions to prevent and tackle infectious disease outbreaks, such as the COVID-19 pandemic. The results showed that this limitation significantly impacted the ECDC, as the Member States' competence did not allow the agency to have more capacity. The European Commission has fulfilled its role of coordinating and supporting the Member States by facilitating networks and information exchange. However, EU intra- and inter-communication need further improvement. Although diverse EU instruments and mechanisms were found valid, their implementation needed to be faster and more efficient. The results pointed out that underlying political challenges in EU decision-making regarding health emergencies hinder the aligned response. It was stated that the Member States were not prepared, and due to the restriction of their mandate, EU institutions could not enforce binding guidelines. Additionally, the study explored future EU pandemic strategies and actions. Both, EU institutions and national experts suggested similar and clear recommendations regarding the ECDC, the investment, and future harmonized preparedness tools.

Conclusion: The complex politics of public health at the EU level have led to the fragmentation of its governance for effective pandemic responses. This ongoing pandemic has shed light on the fragility of the political and structural systems in Europe in public health emergencies. Health should be of high importance in the political agenda, and robust health reforms at the local, regional, national, and EU levels are highly recommended.
Use of X-Ray Fluorescence Microscopy for Studies on Research Models of Hepatocellular Carcinoma
Authors: Paunesku Tatjana , Gordon Andrew C. , White Sarah , Harris Kathleen , Antipova Olga , Maxey Evan , Vogt Stefan , Smith Anthony , Daddario Luiza , Procissi Daniele , Larson Andrew , Woloschak Gayle E.
Published: August 2021

Introduction: TheraSphere® microspheres containing yttrium 90Y are among many radioembolization agents used clinically to reduce liver tumor burden, and their effects on cancer volume reduction are well-established. At the same time, concerns about off target tissue injury often limit their use. Deeper investigation into tissue distribution and long-term impact of these microspheres could inform us about additional ways to use them in practice.

Methods: Healthy rat liver and rabbit liver tumor samples from animals treated with TheraSpheres were sectioned and their elemental maps were generated by X-ray fluorescence microscopy (XFM) at the Advanced Photon Source (APS) synchrotron at Argonne National Laboratory (ANL).

Results: Elemental imaging allowed us to identify the presence and distribution of TheraSpheres in animal tissues without the need for additional sample manipulation or staining. Ionizing radiation produced by 90Y radioactive contaminants present in these microspheres makes processing TheraSphere treated samples complex. Accumulation of microspheres in macrophages was observed.

Conclusions: This is the first study that used XFM to evaluate the location of microspheres and radionuclides in animal liver and tumor samples introduced through radioembolization. XFM has shown promise in expanding our understanding of radioembolization and could be used for investigation of human patient samples in the future.
Numerical Algorithm for Dynamic Impedance of Bridge Pile-Group Foundation and Its Validation
Authors: Wang Chenyu , Qiao Hong , Wang Yi , Du Xianting
Published: August 2021

The characteristics of bridge pile-group foundation have a significant influence on the dynamic performance of the superstructure. Most of the existing analysis methods for the pile-group foundation impedance take the trait of strong specialty, which cannot be generalized in practical projects. Therefore, a project-oriented numerical solution algorithm is proposed to compute the dynamic impedance of bridge pile-group foundation. Based on the theory of viscous-spring artificial boundary, the derivation and solution of the impedance function are transferred to numerical modeling and harmonic analysis, which can be carried out through the finite element method. By taking a typical pile-group foundation as a case study, the results based on the algorithm are compared with those from existing literature. Moreover, an impact experiment of a real pile-group foundation was implemented, the results of which are also compared with those resulting from the proposed numerical algorithm. Both comparisons show that the proposed numerical algorithm satisfies engineering precision, thus showing good effectiveness in application.
Optimization of Structure Parameters of the Grouser Shoes for Adhesion Reduction under Black Soil
Authors: Fu Jun , Li Jian , Tang Xinlong , Wang Ruixue , Chen Zhi
Published: August 2021

The black soil of Northeast China has a strong adhesion ability because of its unique physical properties, and the soil often adheres to the surface of the grouser shoes of tracked vehicles during the operation. The adhesion performance depends largely on structure parameters of the grouser shoes. The grouser height, the grouser thickness, and the grouser splayed angle were selected as structure parameters. The adhesion force and adhesive soil mass were selected as indicators of adhesion performance. Therefore, the mathematical model between structure parameters and response indicators was established by the response surface method (RSM). The optimal parameters combination was that the grouser height was 20 mm, grouser thickness was 6.34 mm, and grouser splayed angle was 40.45°. The average data of verification experiments occurred when the adhesion force reached 1.11 kPa and adhesive soil mass reached 22.68 g. Compared with the average value of un-optimized experiment results, the adhesion force and adhesive soil mass reduced by 12.84% and 4.63%, respectively. The relative error of the predicted values and measured values was less than 5%, proving the reliability of the regression models. This study could provide a reference method for parameters optimization, and a new structure of the grouser shoes of tracked vehicles will be designed to reduce adhesion.
Simultaneous Calibration of Grapevine Phenology and Yield with a Soil–Plant–Atmosphere System Model Using the Frequentist Method
Authors: Yang Chenyao , Menz Christoph , Fraga Helder , Reis Samuel , Machado Nelson , Malheiro Aureliano C. , Santos João A.
Published: August 2021

Reliable estimations of parameter values and associated uncertainties are crucial for crop model applications in agro-environmental research. However, estimating many parameters simultaneously for different types of response variables is difficult. This becomes more complicated for grapevines with different phenotypes between varieties and training systems. Our study aims to evaluate how a standard least square approach can be used to calibrate a complex grapevine model for simulating both the phenology (flowering and harvest date) and yield of four different variety–training systems in the Douro Demarcated Region, northern Portugal. An objective function is defined to search for the best-fit parameters that result in the minimum value of the unweighted sum of the normalized Root Mean Squared Error (nRMSE) of the studied variables. Parameter uncertainties are estimated as how a given parameter value can determine the total prediction variability caused by variations in the other parameter combinations. The results indicate that the best-estimated parameters show a satisfactory predictive performance, with a mean bias of −2 to 4 days for phenology and −232 to 159 kg/ha for yield. The corresponding variance in the observed data was generally well reproduced, except for one occasion. These parameters are a good trade-off to achieve results close to the best possible fit of each response variable. No parameter combinations can achieve minimum errors simultaneously for phenology and yield, where the best fit to one variable can lead to a poor fit to another. The proposed parameter uncertainty analysis is particularly useful to select the best-fit parameter values when several choices with equal performance occur. A global sensitivity analysis is applied where the fruit-setting parameters are identified as key determinants for yield simulations. Overall, the approach (including uncertainty analysis) is relatively simple and straightforward without specific pre-conditions (e.g., model continuity), which can be easily applied for other models and crops. However, a challenge has been identified, which is associated with the appropriate assumption of the model errors, where a combination of various calibration approaches might be essential to have a more robust parameter estimation.
Investigations on the Effects of Different Calcium Supply Exceeding the Requirements on Mineral Serum Concentrations and Bone Metabolism in Young Warmblood Stallions
Authors: Schubert Dana Carina , Neustädter Lisa-Theresa , Coenen Manfred , Visscher Christian , Kamphues Josef
Published: August 2021

Since mineral supplements for horses commonly contain macro minerals, although the requirement for such is usually covered by roughage-based diets, the aim of this study was to investigate the effects of different dietary calcium levels on mineral serum concentrations and bone metabolism. The trial was conducted in 30 young warmblood stallions (2–3 years) that were divided into two groups for a five-month feeding trial. The groups were fed a hay- and oat-based diet and were either supplied with high (Ca-High) or moderate (Ca-Moderate) calcium excess. While in Ca-High calcium supply was about 2–2.5-fold of the requirement, in Ca-Moderate calcium requirements were slightly surpassed (1.5–1.6-fold). In order to monitor the effects of the different calcium supply, blood samples were taken during the trial and analysed for levels of macro and trace elements as well as concentrations of two bone markers. In Ca-Moderate a trend towards higher phosphorus serum levels compared to Ca-High was observed which was significant at the end of the trial (p = 0.0002). Furthermore, results showed no influence of the diet on bone markers. Results support the idea that forage-based rations for horses do not necessarily have to be supplemented with macro minerals but with trace elements.
Functional Neurorehabilitation in Dogs with an Incomplete Recovery 3 Months following Intervertebral Disc Surgery: A Case Series
Authors: Martins Ângela , Gouveia Débora , Cardoso Ana , Carvalho Carla , Silva Cátia , Coelho Tiago , Gamboa Óscar , Ferreira António
Published: August 2021

This case series study aimed to evaluate the safety, feasibility, and positive outcome of the neurorehabilitation multimodal protocol (NRMP) in 16 chronic post-surgical IVDD Hansen type I dogs, with OFS 0/DPP− (n = 9) and OFS 1/DPP+ (n = 7). All were enrolled in the NRMP for a maximum of 90 days and were clinically discharged after achieving ambulation. The NRMP was based on locomotor training, functional electrical stimulation, transcutaneous electrical spinal cord stimulation, and 4-aminopyridine (4-AP) pharmacological management. In the Deep Pain Perception (DPP)+ dogs, 100% recovered ambulation within a mean period of 47 days, reaching OFS ≥11, which suggests that a longer period of time is needed for recovery. At follow-up, all dogs presented a positive evolution with voluntary micturition. Of the DPP− dogs admitted, all achieved a flexion/extension locomotor pattern within 30 days, and after starting the 4-AP, two dogs were discharged at outcome day 45, with 78% obtaining Spinal Reflex Locomotion (SRL) and automatic micturition within a mean period of 62 days. At follow-up, all dogs maintained their neurological status. After the NRMP, ambulatory status was achieved in 88% (14/16) of dogs, without concurrent events. Thus, an NRMP may be an important therapeutic option to reduce the need for euthanasia in the clinical setting.
On the Helminth Fauna of the Muskrat (Ondatra zibethicus (Linnaeus, 1766)) in the Barnim District of Brandenburg State/Germany
Authors: Schuster Rolf K. , Specht Peter , Rieger Siegfried
Published: August 2021

The muskrat is a neozoon species that has occupied many countries of continental North Europe after its introduction from north America as fur animals. Due to its burrowing activity it damages river and canal banks and structures of flood control. For this reason, the eradication of this alien species is recommended. Muskrats are also of parasitological interest since they can act as suitable intermediate hosts for Echinococcus multilocularis. On the other hand, little is known on the other helminths that infect muskrats. A total of 130 muskrats of different age groups trapped in different habitats in the Barnim district of the Brandenburg state by a professional hunter were examined for parasites and seven trematodes (Echinostoma sp., Notocotylus noyeri, Plagiorchis elegans, Plagiorchis arvicolae, Psilosostoma simillimum, P. spiculigerum, Opisthorchis felineus and four larval cestode species (Hydatigera taeniaeformis, Taenia martis, Taenia polyacantha, Taenia crassiceps) were detected. Larval stages of E. multilocularis were not found. O. felineus was found for the first time in muskrats in Germany. All the named parasites were present in Europe prior to the introduction of muskrats. With a prevalence of 48.9%, Strobilocercus fasciolaris, the larval stage of the cat tapeworm, H. taeniaeformis, was the most frequent parasite found in adult muskrats.
The Implications of Changing Age and Weight at Slaughter of Heavy Pigs on Carcass and Green Ham Quality Traits
Authors: Malgwi Isaac Hyeladi , Gallo Luigi , Halas Veronika , Bonfatti Valentina , Carcò Giuseppe , Sasso Celio Paolo , Carnier Paolo , Schiavon Stefano
Published: August 2021

Italian dry-cured ham production requires pigs to be slaughtered at 160 ± 16 kg at 9 months of age (control, C). The study explored three alternatives, based on different feeding conditions: (1) allowing pigs to express their growth potential by letting them reach 160 ± 16 kg slaughter weight (SW) at younger slaughter age (SA) (younger Age, YA); (2) allowing pigs to express their growth potential by maximizing their SW at 9 months SA (greater weight, GW); (3) increasing the SA required to reach 160 ± 16 kg SW (older age, OA). Pigs (336 C21 Goland, 95 kg initial body weight) were slaughtered on average at 257, 230, 257, and 273 d SA and 172.7, 172.3, 192.9, and 169.3 SW kg for the four treatments, respectively. C pigs had an average daily gain (ADG) of 715 g/d and feed efficiency (FE) of 0.265 (gain to feed). Compared to C, YA pigs had higher ADG (+32%), FE (+7.5%), and better ham adiposity; GW pigs had higher carcass weight (+12%), ADG (+25%), trimmed ham weight (+10.9%), and better ham adiposity. OA treatment affected ADG (−16.4%), FE (−16.6%), and trimmed ham weight (−3.6%). YA and GW could be promising alternatives to C as they improved FE and ham quality traits.
Efflux Might Participate in Decreased Susceptibility to Oxytetracycline in Contagious Agalactia-Causative Mycoplasma spp.
Authors: Tatay-Dualde Juan , Prats-van der Ham Miranda , Gaurivaud Patrice , de la Fe Christian , Tardy Florence
Published: August 2021

Contagious agalactia is associated with mastitis, keratoconjunctivitis, arthritis, pneumonia, and septicemia in small ruminants in countries with large dairy industries worldwide. The causative agents belong to four (sub)species of the Mycoplasma genus that have remained essentially susceptible to antimicrobials, including to the widely-used tetracycline family. However, some clinical isolates have been detected that show increased minimum inhibitory concentrations of tetracyclines, although they do not harbor the mutation in the 16SrRNA gene usually associated with resistance. The present work aimed to assess whether efflux pumps, infrequently described in mycoplasmas, could participate in the observed moderate loss of susceptibility. General efflux mechanisms were measured (i) using the fluorescence property of ethidium bromide when accumulated intracellularly and intercalated in the mycoplasma genomes, its active extrusion resulting in a temperature-dependent decrease in fluorescence and (ii) monitoring the growth inhibition of mycoplasmas by subinhibitory concentrations of tetracycline with or without reserpine, a known inhibitor of efflux in other bacteria. Both methods revealed non-specific efflux phenomena in most of the isolates tested, although their efficacy was difficult to quantify. This property could contribute to the acquisition of mutations conferring resistance by maintaining intracellular concentrations of tetracyclines at subinhibitory levels.
Extraction of Antioxidant Compounds and Pigments from Spirulina (Arthrospira platensis) Assisted by Pulsed Electric Fields and the Binary Mixture of Organic Solvents and Water
Authors: Martí-Quijal Francisco J. , Ramon-Mascarell Francesc , Pallarés Noelia , Ferrer Emilia , Berrada Houda , Phimolsiripol Yuthana , Barba Francisco J.
Published: August 2021

The application of pulsed electric fields (PEF) is an innovative extraction technology promoting cell membrane electroporation, thus allowing for an efficient recovery, from an energy point of view, of antioxidant compounds (chlorophylls, carotenoids, total phenolic compounds, etc.) from microalgae. Due to its selectivity and high extraction yield, the effects of PEF pre-treatment (3 kV/cm, 100 kJ/kg) combined with supplementary extraction at different times (5–180 min) and with different solvents (ethanol (EtOH)/H2O, 50:50, v/v; dimethyl sulfoxide (DMSO)/H2O, 50:50, v/v) were evaluated in order to obtain the optimal conditions for the extraction of different antioxidant compounds and pigments. In addition, the results obtained were compared with those of a conventional treatment (without PEF pre-treatment but with constant shaking). After carrying out the different experiments, the best extraction conditions to recover the different compounds were obtained after applying PEF pre-treatment combined with the binary mixture EtOH/H2O, 50:50, v/v, for 60–120 min. PEF extraction was more efficient throughout the study, especially at short extraction times (5–15 min). In this sense, recovery of 55–60%, 85–90%, and 60–70% was obtained for chlorophylls, carotenoids, and total phenolic compounds, respectively, compared to the maximum total extracted amount. These results show that PEF improves the extraction yield of antioxidant bioactive compounds from microalgae and is a promising technology due to its profitability and environmental sustainability.
Review of the Potential of Consumer Neuroscience for Aroma Marketing and Its Importance in Various Segments of Services
Authors: Berčík Jakub , Neomániová Katarína , Mravcová Anna , Gálová Jana
Published: August 2021

In the current era of a strongly competitive business environment, it is more difficult for companies to attract customers. Consumer neuroscience has growing potential here, as it reveals internal consumer preferences by using innovative methods and tools, which can effectively examine consumer behavior and attract new customers. In particular, smell has a great ability to subconsciously influence customers and, thus, support profitability. This paper examines the importance of consumer neuroscience and its modern technologies used for exploring human perceptions to influence customers and benefit from the aromatization of business spaces. We focused our analysis on various service sectors. Despite the potential of the examined issue, there are a limited number of studies in the field of service providers that use neuroscience tools to examine the effect of aromas on human emotions. Most studies took place in laboratory conditions, and the used methodological procedures varied widely. Our analysis showed that, in spite of the positive impact of aromatization in the majority of aromatized spaces, service companies still do not use the potential of consumer neuroscience and aroma marketing to a sufficient degree. Innovative methods and tools, in particular, are still very underused.
Alkylimidazolium Ionic Liquids Absorption and Diffusion in Wood
Authors: Croitoru Catalin , Roata Ionut Claudiu
Published: August 2021

Ionic liquids represent a class of highly tunable organic compounds responsible for many applications in the domain of wood-based materials. It has often been emphasized that the use of ionic liquids derives from their high affinity for lignocellulose and their good penetration ability into wood structures. This paper discusses the sorption ability of different types of 1-alkyl-3-methylimidazolium ionic liquids with lateral alkyl chains, ranging from ethyl to hexyl into spruce and beech wood, as a function of their cation molecular mass, anion type (chloride, tetrafluoroborate, acetate), and intrinsic properties (surface tension and kinematic viscosity) at room temperature. All the studied ionic liquids present high relative uptake values at the equilibrium, ranging from 11.2% to 69.7%. The bulk diffusion coefficients of the ionic liquids into the wood range from 2 × 10−3 to 28 × 10−3 mm2/min, being higher in the longitudinal direction for both types of wood. The value of the diffusion coefficients for 1-ethyl-3-methylimidazolium chloride is only 25% lower than that for water, despite the obvious differences in viscosity and surface tension, demonstrating a good penetration ability and the potential for wood industry-related applications (as impregnation compound carriers and preservatives).
MuseStudio: Brain Activity Data Management Library for Low-Cost EEG Devices
Authors: Sánchez-Cifo Miguel Ángel , Montero Francisco , López María Teresa
Published: August 2021

Collecting data allows researchers to store and analyze important information about activities, events, and situations. Gathering this information can also help us make decisions, control processes, and analyze what happens and when it happens. In fact, a scientific investigation is the way scientists use the scientific method to collect the data and evidence that they plan to analyze. Neuroscience and other related activities are set to collect their own big datasets, but to exploit their full potential, we need ways to standardize, integrate, and synthesize diverse types of data. Although the use of low-cost ElectroEncephaloGraphy (EEG) devices has increased, such as those whose price is below 300 USD, their role in neuroscience research activities has not been well supported; there are weaknesses in collecting the data and information. The primary objective of this paper was to describe a tool for data management and visualization, called MuseStudio, for low-cost devices; specifically, our tool is related to the Muse brain-sensing headband, a personal meditation assistant with additional possibilities. MuseStudio was developed in Python following the best practices in data analysis and is fully compatible with the Brain Imaging Data Structure (BIDS), which specifies how brain data must be managed. Our open-source tool can import and export data from Muse devices and allows viewing real-time brain data, and the BIDS exporting capabilities can be successfully validated following the available guidelines. Moreover, these and other functional and nonfunctional features were validated by involving five experts as validators through the DESMET method, and a latency analysis was also performed and discussed. The results of these validation activities were successful at collecting and managing electroencephalogram data.
Intraosseous Squamous Cell Carcinoma Associated with Denosumab-Induced Osteonecrosis of the Jaw
Authors: Bacián Martínez Sandra , Navarro Cuéllar Carlos , Navarro Vila Carlos , Palacios Weiss Edurne , Pujol Romanyá Roser , del Amo Fernández de Velasco Álvaro , Escrig de Teijeiro Margarita , del Castillo Pardo de Vera José Luis , Rodríguez Pérez Irene , Sánchez-Pérez Arturo , Zamorano-León José J. , López-Farré Antonio , García-Hidalgo Alonso María Isabel , Navarro Cuéllar Ignacio
Published: August 2021

Medication-related osteonecrosis of the jaw (MRONJ) has been associated with the use of different drugs administered in the treatment of malignant neoplasms or metastases and in antiresorptive therapies. Since 2010, denosumab, a monoclonal antibody whose mechanism of action is to prevent the activation of the RANK receptor on the surface of osteoclasts, has been associated with osteonecrosis of the jaw. Primary intraosseous squamous cell carcinoma (PIOSCC) is a rare neoplasm characterised by the presence of squamous cells within the maxillary or mandibular bone without an initial clinical association with the oral mucosa. We present a case of a PIOSCC in an osteonecrosis of the jaw related to a patient who received antiresorptive treatment with denosumab outlining the clinical and histopathological features of MRONJ and PIOSCC.
Noise Measurement and Reduction in Mode-Locked Lasers: Fundamentals for Low-Noise Optical Frequency Combs
Authors: Tian Haochen , Song Youjian , Hu Minglie
Published: August 2021

After five decades of development, mode-locked lasers have become significant building blocks for many optical systems in scientific research, industry, and biomedicine. Advances in noise measurement and reduction are motivated for both shedding new light on the fundamentals of realizing ultra-low-noise optical frequency combs and their extension to potential applications for standards, metrology, clock comparison, and so on. In this review, the theoretical models of noise in mode-locked lasers are first described. Then, the recent techniques for timing jitter, carrier-envelope phase noise, and comb-line noise measurement and their stabilization are summarized. Finally, the potential of the discussed technology to be fulfilled in novel optical frequency combs, such as electro-optic (EO) modulated combs, microcombs, and quantum cascade laser (QCL) combs, is envisioned.
Measuring Ocean Surface Current in the Kuroshio Region Using Gaofen-3 SAR Data
Authors: Li Yan , Chong Jinsong , Sun Kai , Zhao Yawei , Yang Xue
Published: August 2021

The Kuroshio is the strongest warm current in the western North Pacific, which plays a crucial role in climate and human activities. In terms of this, the accurate acquisition of ocean surface current velocity and direction in the Kuroshio region is of great research value. Gaofen-3 synthetic aperture radar (SAR) provides data support for the study of ocean surface current measurements in the Kuroshio region, but no relevant experimental result has been published yet. In this paper, four available stripmap mode SARs’ data acquired by Gaofen-3 in the Kuroshio region are used for measuring the ocean surface current field. In general, the Doppler centroid anomaly (DCA) estimation is a common method to infer ocean surface currents from single-antenna stripmap data, but only the radial velocity component can be retrieved. In order to measure current vectors, a novel method combining the sub-aperture processing and the least squares (LS) technology is suggested and demonstrated by applying to the Gaofen-3 SAR data processing. The experiment’s results agree well with model-derived ocean current data, indicating that the Gaofen-3 SAR has the capability to accurately retrieve the ocean surface current field in the Kuroshio region and motivate further research by providing more data.
Surface Defect Detection Methods for Industrial Products: A Review
Authors: Chen Yajun , Ding Yuanyuan , Zhao Fan , Zhang Erhu , Wu Zhangnan , Shao Linhao
Published: August 2021

The comprehensive intelligent development of the manufacturing industry puts forward new requirements for the quality inspection of industrial products. This paper summarizes the current research status of machine learning methods in surface defect detection, a key part in the quality inspection of industrial products. First, according to the use of surface features, the application of traditional machine vision surface defect detection methods in industrial product surface defect detection is summarized from three aspects: texture features, color features, and shape features. Secondly, the research status of industrial product surface defect detection based on deep learning technology in recent years is discussed from three aspects: supervised method, unsupervised method, and weak supervised method. Then, the common key problems and their solutions in industrial surface defect detection are systematically summarized; the key problems include real-time problem, small sample problem, small target problem, unbalanced sample problem. Lastly, the commonly used datasets of industrial surface defects in recent years are more comprehensively summarized, and the latest research methods on the MVTec AD dataset are compared, so as to provide some reference for the further research and development of industrial surface defect detection technology.
Re-Visiting Acoustic Sounding to Advance the Measurement of Optical Turbulence
Authors: Fiorino Steven , Bose-Pillai Santasri , Keefer Kevin
Published: August 2021

Optical turbulence, as determined by the widely accepted practice of profiling the temperature structure constant, CT2, via the measurement of ambient atmospheric temperature gradients, can be found to differ quite significantly when characterizing such gradients via thermal-couple differential temperature sensors as compared to doing so with acoustic probes such as those commonly used in sonic anemometry. Similar inconsistencies are observed when comparing optical turbulence strength derived via CT2 as compared to those through direct optical or imaging measurements of small fluctuations of the index of refraction of air (i.e., scintillation). These irregularities are especially apparent in stable atmospheric layers and during diurnal quiescent periods. Our research demonstrates that when care is taken to properly remove large-scale index of refraction gradients, the sonic anemometer-derived velocity structure constant, Cv2, coupled with the similarly derived turbulence-driven index of refraction and vertical wind shear gradients, provides a refractive index structure constant, Cn2, that can more closely match the optical turbulence strengths inferred by more direct means such as scintillometers or differential image motion techniques. The research also illustrates the utility and robustness of quantifying Cn2 from CT2 at a point using a single sonic anemometer and establishes a clear set of equations to calculate volumetric Cn2 data using instrumentation that measures wind velocities with more spatial/temporal fidelity than temperature.
Multi-Objective Aerodynamic Design Optimisation Method of Fuel Cell Centrifugal Impeller Using Modified NSGA-II Algorithm
Authors: Liu Jisheng , Li Wei , Liu Manxian , He Ketai , Wang Yesong , Fang Pengcheng
Published: August 2021

This paper presents a modified NSGA-II algorithm based on the spatial density (SD) operator, combined with computer graphics-based surface parameterisation methods and computational fluid dynamics (CFD) simulations. This was done to optimise the multi-objective aerodynamic design of a centrifugal impeller for a 100-kW vehicle-mounted fuel cell and improve the multi-conditions aerodynamic performance of the centrifugal impeller of the vehicle-mounted fuel cell (FC). The optimisation objectives are to maximise the isentropic efficiency of the rated and common operating conditions. The optimisation results showed that the efficiency of rated working conditions had an increase of 1.29%, mass flow increase of 8.8%, pressure ratio increase of 0.74% and comprehensive margin increase of 6.2%. The efficiency of common working conditions had an increase of 1.2%, mass flow increase of 9.1%, pressure ratio increase of 0.24% and comprehensive margin increase of 10%. The optimisation effect is obvious under the premise of satisfying the constraints, which proves the optimisation method’s engineering effectiveness and provides technical support and methodological research for the multi-objective aerodynamic design optimisation of centrifugal impellers for vehicle-mounted FCs.
A Hybrid DenseNet-LSTM Model for Epileptic Seizure Prediction
Authors: Ryu Sanguk , Joe Inwhee
Published: August 2021

The number of people diagnosed with epilepsy as a common brain disease accounts for about 1% of the world’s total population. Seizure prediction is an important study that can improve the lives of patients with epilepsy, and, in recent years, it has attracted more and more attention. In this paper, we propose a novel hybrid deep learning model that combines a Dense Convolutional Network (DenseNet) and Long Short-Term Memory (LSTM) for epileptic seizure prediction using EEG data. The proposed method first converts the EEG data into the time-frequency domain through Discrete Wavelet Transform (DWT) for use in the input of the model. Then, we train the previously transformed image through a hybrid model combining Densenet and LSTM. To evaluate the performance of the proposed method, experiments are conducted for each preictal length of 5, 10, and 15 min using the CHB-MIT scalp EEG dataset. As a result, we obtained a prediction accuracy of 93.28%, a sensitivity of 92.92%, a specificity of 93.65%, a false positive rate of 0.063 per hour, and an F1-score of 0.923 when the preictal length was 5 min. Finally, as the proposed method is compared to previous studies, it is confirmed that the seizure prediction performance was improved significantly.
Improving Ship Maneuvering Safety with Augmented Virtuality Navigation Information Displays
Authors: Gralak Rafał , Muczyński Bartosz , Przywarty Marcin
Published: August 2021

The paper presents the results of a study on improving the safety of navigation, during maneuvers in restricted areas, with the use of an augmented virtuality navigation information display. The augmented virtuality solution has been developed by one of the authors and has been described in a previous paper. A set of simulation scenarios has been proposed to study various maneuvers with different types of ships. Models of existing areas and existing ships have been used so the study can be recreated and reevaluated with different types of interfaces. The study is focused on comparing safe maneuvering areas with different information sources used. The results showed that augmented virtuality solution can indeed decrease the safe maneuvering areas and thus increase the safety of navigation for maneuvers in restricted areas.
Effect on Mouse Liver Morphology of CeO2, TiO2 and Carbon Black Nanoparticles Translocated from Lungs or Deposited Intravenously
Authors: Modrzynska Justyna , Mortensen Alicja , Berthing Trine , Ravn-Haren Gitte , Szarek Józef , Saber Anne Thoustrup , Vogel Ulla
Published: August 2021

Exposure to nanoparticles by various routes results in size-dependent translocation of nanoparticles to the systemic circulation and subsequent accumulation in the liver. The purpose of this study was to determine possible adverse effects in the liver of long-lasting nanoparticle presence in the organ. Mice exposed to a single dose (162 µg/animal equivalent to 9 mg/kg body weight) of TiO2, CeO2 or carbon black nanoparticles by intratracheal instillation or intravenous injection, resulting in relatively low or high liver burdens, were followed for 1, 28 or 180 days. Clinical appearance, feed intake, body and liver weights, hematological indices, and transaminases and alkaline phosphatase activities were unaffected by exposure. Exposure-related foreign material persisted in the liver up to 180 days after intratracheal and intravenous exposure, mainly in sinusoids, near Kupffer cells, or around blood vessels. Increased incidences of histological findings after intratracheal or intravenous exposure included: initially, prominent nuclei of Kupffer cells, the apparent increase in binucleate hepatocytes (TiO2 and carbon black) and inflammatory infiltrations (CeO2); later, cytoplasmic vacuolation, pyknosis and necrosis, especially for CeO2. Thus, neither low nor high nanoparticle burden in the liver affected enzymatic markers of liver injury, but indications of exposure-related necrotic changes, particularly for CeO2 nanoparticles, were noted.
Impact of the Epigenetically Regulated Hoxa-5 Gene in Neural Differentiation from Human Adipose-Derived Stem Cells
Authors: Hernández Rosa , Jiménez-Luna Cristina , Ortiz Raúl , Setién Fernando , López Miguel , Perazzoli Gloria , Esteller Manel , Berdasco María , Prados Jose , Melguizo Consolación
Published: August 2021

Human adipose-derived mesenchymal stem cells (hASCs) may be used in some nervous system pathologies, although obtaining an adequate degree of neuronal differentiation is an important barrier to their applicability. This requires a deep understanding of the expression and epigenetic changes of the most important genes involved in their differentiation. We used hASCs from human lipoaspirates to induce neuronal-like cells through three protocols (Neu1, 2, and 3), determined the degree of neuronal differentiation using specific biomarkers in culture cells and neurospheres, and analyzed epigenetic changes of genes involved in this differentiation. Furthermore, we selected the Hoxa-5 gene to determine its potential to improve neuronal differentiation. Our results showed that an excellent hASC neuronal differentiation process using Neu1 which efficiently modulated NES, CHAT, SNAP25, or SCN9A neuronal marker expression. In addition, epigenetic studies showed relevant changes in Hoxa-5, GRM4, FGFR1, RTEL1, METRN, and PAX9 genes. Functional studies of the Hoxa-5 gene using CRISPR/dCas9 and lentiviral systems showed that its overexpression induced hASCs neuronal differentiation that was accelerated with the exposure to Neu1. These results suggest that Hoxa-5 is an essential gene in hASCs neuronal differentiation and therefore, a potential candidate for the development of cell therapy strategies in neurological disorders.
Increased CD3+, CD8+, or FoxP3+ T Lymphocyte Infiltrations Are Associated with the Pathogenesis of Colorectal Cancer but Not with the Overall Survival of Patients
Authors: Barbosa Ana Margarida , Martinho Olga , Nogueira Rosete , Campos Juliana , Lobo Liliana , Pinto Henrique , Longatto-Filho Adhemar , Castro António G. , Martins Sandra F. , Torrado Egídio
Published: August 2021

Tumor-infiltrating lymphocytes include heterogeneous populations of T lymphocytes that play crucial roles in the tumor immune response; importantly, their presence in the tumor tissue may predict clinical outcomes. Therefore, we herein studied the prognostic significance of the presence and location of CD3+, CD8+, and FoxP3+ T lymphocytes in colorectal cancer samples. In the intratumor analysis, our data did not reveal any association between lymphocyte infiltrations with clinical or pathological data. However, in the tumor margins, we found that the presence of high infiltrations of CD3+, CD8+, or FoxP3+ T lymphocytes were associated with TNM stages I-II (p = 0.021, p = 0.022, and p = 0.012, respectively) and absence of lymph node metastases (p = 0.010, p = 0.003, and p = 0.004, respectively). Despite these associations with good prognostic indicators, we were not able to find any statistically significant alterations in the overall survival of the patients, even though high infiltrations of FoxP3+ T lymphocytes in the tumor margins resulted in an increased overall survival of 14 months. Taken together, these data show that the presence of CD3+, CD8+, or FoxP3+T lymphocyte infiltrates in the tumor margins are associated with the pathogenesis of CRC, but only high Foxp3+ T lymphocyte infiltrations in the tumor invasive margins are inclined to indicate favorable prognosis.
Pinocembrin Ameliorates Skin Fibrosis via Inhibiting TGF-β1 Signaling Pathway
Authors: Li Xiaohe , Zhai Yunqian , Xi Buri , Ma Wei , Zhang Jianwei , Ma Xiaoyang , Miao Yang , Zhao Yongjian , Ning Wen , Zhou Honggang , Yang Cheng
Published: August 2021

Skin fibrotic diseases, such as keloids, are mainly caused by pathologic scarring of wounds during healing and characterized by benign cutaneous overgrowths of dermal fibroblasts. Current surgical and therapeutic modalities of skin fibrosis are unsatisfactory. Pinocembrin, a natural flavonoid, has been shown to possess a vast range of pharmacological activities including antimicrobial, antioxidant, anti-inflammatory, and anti-tumor activities. In this study we explored the potential effect and mechanisms of pinocembrin on skin fibrosis in vitro and in vivo. In vitro studies indicated that pinocembrin dose-dependently suppressed proliferation, migration, and invasion of keloid fibroblasts and mouse primary dermal fibroblasts. The in vivo studies showed that pinocembrin could effectively alleviate bleomycin (BLM)-induced skin fibrosis and reduce the gross weight and fibrosis-related protein expression of keloid tissues in xenograft mice. Further mechanism studies indicated that pinocembrin could suppress TGF-β1/Smad signaling and attenuate TGF-β1-induced activation of skin fibroblasts. In conclusion, our results demonstrate the therapeutic potential of pinocembrin for skin fibrosis.