bluuebunny/crossref_metadata_2025 huggingface dataset:
Landscape fires in the Irkutsk region: environmental impact
Authors: Timofeeva S. S. , Garmyshev V. V.
Published: July 2022

The paper considers the problem of pollution of the air basin by landscape fires in the municipalities of the Baikal region. The factorological basis of the study was the taxational characteristics of natural plantings and statistical data on the consequences of landscape fires for 2014-2020. The taxation values of natural territories and consequences of landscape fires were used to formulate a methodological approach to the type and mass of burnt plant materials. The consequences of landscape fires were determined, and calculations were performed; qualitative and quantitative values of burned materials were obtained for the municipalities under study. Taking into account the specific indicators of emissions of pollutants during the burning of stands, forest combustible materials, mass values of burned forest materials, and gross emissions of pollutants into the atmosphere were determined.
Features of high-density transient electromagnetic sounding data inversion under oil and gas prospecting in the Nepa-Botuoba anteclise area
Authors: Murzina E. V. , Pospeev A. V. , Seminskiy I. K. , Buddo I. V. , Nemtseva D. B. , Emelianov V. S. , Agafonov Y. A.
Published: July 2022

The data of near-field transient electromagnetic sounding, which are widely used for the purposes of oil and gas exploration within the Nepa-Botuoba anteclise, are typically interpreted in terms of quasi-horizontally-layered models of media. The purpose of this study is to develop an approach to the inversion of transient electromagnetic sounding curves obtained via high-density 3D observation networks. The study was based on mathematical modeling, whose results allowed to estimate the lateral spatial parameters of a non-stationary electromagnetic field as well as to understand the differences between the results of one-dimensional inversion of the transient electromagnetic sounding data and the true parameters of the target horizon. As a result, the characteristic of the electromagnetic field described by an exponential function and used in the lateral-constraint inversion of high-density electromagnetic sounding was obtained. The proposed approach was tested on the practical data within the site under investigation located on the slope of the Nepa-Botuobа anteclise. It is shown that the use of spatial discrepancy under TEM sounding data inversion makes it possible to obtain geoelectric models characterized by lateral consistency of section geoelectric parameters. The application of the spatial stacking-based approach in the inversion process allows to increase the solution stability of the inverse problem of the near-field TEM sounding data.
Study of gold ore processing by flotation methods
Authors: Fedotov P. K. , Burdonov A. E. , Novikov Yu. V. , Terentiev N. V. , Bogdanyuk I. O.
Published: July 2022

The article deals with the studies of gold-bearing ore benefication by flotation methods. The object of the study is a low-sulfide gold-quartz type of ores with the following petrographic composition: quartz – 90 %, quartz-chlorite schists – 10 %. The ore from this deposit consists of the weathering crust rocks including iron-mica rocks with veins and spots of granoblastic quartz. The purpose of the research is to develop an optimal flotation regime for obtaining sulfide gold-bearing concentrate. The influence of ore size, reagent mode, flotation redistribution structure, and flotation time on operations was recorded during the experiment. The paper presents the results of studying the chemical composition of the ore by the method of silicate and optical emission analysis. The flotation process used butyl potassium xanthate as a collector and a combination of pine essential oils as a foaming agent. The Hancock concentration efficiency criterion was determined based on a series of experiments. The following technological indicators of ore processing were identified: gravity concentrate with the gold grade of 1165 g/t with the yield of 0.3 % and the recovery of 73.74 %; flotation concentrate (after purification II) with the gold grade of 68.9 g/t with the yield of 1.52 % and a recovery of 22.05 %. Its silver content was 15.9 g/t. The total gold recovery was 95.79 %, with the yield of 1.82 % and the gold grade of 249.9 g/t. The gold grade in the flotation tailings was 0.19 g/t.
O debate parlamentar sobre a nova política de drogas na Câmara dos Deputados: formações discursivas e biopolíticas
Authors: Cerqueira Wanessa Gabrielle Maia , Barros Antonio Teixeira de
Published: July 2022

O artigo analisa o debate parlamentar sobre a nova Política Nacional de Drogas (Lei nº 13.840/19) na Câmara dos Deputados. O objetivo é identificar as formações discursivas nas quais se baseiam tais discursos, correlacionando-as com visões orientadas por biopolíticas. O problema de pesquisa é expresso pela seguinte questão: quais são as ideologias preponderantes no debate parlamentar acerca da produção, comercialização e consumo de substâncias psicoativas? A hipótese que guia o estudo consiste na premissa de que os parlamentares têm, progressivamente, adotado um discurso sanitarista, tratando os usuários como indivíduos doentes que necessitam da tutela estatal para cuidar de sua saúde, mediante internação compulsória. Para a realização da pesquisa analisamos as notas taquigráficas dos debates durante a votação da matéria no Plenário da Câmara dos Deputados, totalizando 70 pronunciamentos. As conclusões confirmam a hipótese, com o predomínio da formação discursiva sanitarista. Além disso, foram identificadas: uma formação discursiva punitivista, que defende mais rigor na punição dos traficantes; uma formação discursiva libertária, identificada em poucos pronunciamentos, que se baseia no respeito ao livre-arbítrio, sem interferência do Estado na vida privada do indivíduo.
Desenvolvimento Econômico a a Função Judicante na Efetivação dos Direitos Fundamentais Sociais
Authors: Borges de Oliveira Emerson Ademir , Freitas de Oliveira Edson
Published: July 2022

O presente estudo propõe uma reflexão sobre o papel do Poder Judiciário na satisfação de direitos fundamentais sociais. Analisa, inicialmente, o que representa, pela concepção atual, o verdadeiro desenvolvimento econômico, voltado para a solução das mazelas sociais individuais, e não para o acúmulo global de riquezas. Discute e demonstra o papel do Estado na busca do desenvolvimento econômico após a edição da Constituição Federal de 1988. Faz uma breve, porém necessária, abordagem sobre a análise econômica do direito voltada ao atendimento pelo Estado dos direitos sociais previstos na Constituição. Estuda a aplicação dos recursos orçamentários públicos, reconhecendo a sua finitude e escassez e abordando as teorias que foram desenvolvidas em torno da alocação de recursos públicos: escolhas trágicas, reserva do possível e mínimo existencial. Demonstra, com base em estudos específicos sobre a matéria, que o Poder Judiciário tem apresentado falhas severas no atendimento ao jurisdicionado, o que, por si só, prejudica a efetividade dos direitos sociais através da função judicante do Estado. Reconhece que as decisões judiciais são fundamentais para assegurar direitos e trazer equilíbrio à sociedade, mas identifica ingerências do Judiciário no orçamento público provocadas por essas decisões, especialmente pela ausência de estudos prévios e planejamento. Defendendo que recursos públicos mal aplicados geram reflexos negativos para o desenvolvimento econômico (pela necessidade de mais arrecadação tributária e consequente queda na geração de empregos e riquezas), propõe que estudos profundos sejam realizados para que se decida, inclusive, pela correta alocação de recursos e pelo afastamento parcial do Judiciário, reservando-se à iniciativa privada – ao mercado – a solução das mazelas sociais brasileiras, através do próprio crescimento econômico. Em termos metodológicos, vale-se da técnica dedutiva, a partir, eminentemente, de pesquisa bibliográfica e jurisprudencial.
Blue and gray water footprint of some Hungarian milking parlors
Authors: Hodúr Cecilia , Nagypál Virág , Fazekas Ákos , Mikó Edit
Published: July 2022

Unpredictable weather conditions urge us to find sustainable water management solutions. This research gives examples for dairy farmers on how to assess water use, calculate water footprint (WF), and find water-saving opportunities. Three large-scale Hungarian dairy farms were selected to assess water use and WF based on characteristics that answer to this research's hypothesis: there is a correlation between milking technology and WF. The WF of feeding was excluded from this research. In a farm using a parallel milking system (Farmpl), the amount of service water, and thus the footprint of blue water, was the highest, more than twice at the polygon (Farmpoly) or robotic (Farmrob) milking parlor service water. The milking robot was less advantageous in water use than polygon milking. The gray water footprint was the most unfavorable for Farmrob. If blue, green, and gray WFs are clarified within a farm, it will be easier to investigate the water uses of dairy farms and assess the ratio of each water category. These data can serve as the basis for dairy farmers dealing with Holstein Friesian cattle for assessment of their water management. The novelty of this research is that no study has investigated the relationship between milking technology and WF.
Evolution of hydrochemistry and isotopic characteristics in shallow alluvial aquifers of Poyang Lake Basin, Eastern China
Authors: Chu Xiaodong , Wang Hao , Li Liangzhong , Ma Zhifei , Wu Daishe , Chen Ting
Published: July 2022

The hydrochemical characteristics of shallow groundwater and the factors affecting them were analyzed using descriptive statistical analysis, Piper trilinear charts, Gibbs charts, and ion ratios, to help improve the groundwater quality of the Poyang Lake Plain. The results showed that the groundwater was weakly acidic, with an average pH of 6.27. was the main ion component, with high stability in the study area. The chemical ions in groundwater were mainly controlled by rock weathering, and Ca2+ and Mg2+ originated from the dissolution of carbonate, silicate, or evaporite. Cation exchange was an important driving factor in the formation of groundwater chemical components in the study area. The shallow groundwater and surface water in the region around Poyang Lake are replenished by precipitation, but both are more affected by evaporation. The large d-excess value indicated that the groundwater was greatly affected by water–rock interactions. The main source of is chemical fertilizer and levels were less affected by domestic sewage, which may be because the study area is a traditional agricultural area. Rock weathering, leaching, and human activities were the main driving factors for the evolution of the chemical characteristics of the groundwater in the study area. These results provide a technical reference and the basis for regional collaborative efforts to control groundwater and surface water pollution.
Spirituality in organizations and professional stress during Covid-19
Authors: Lopes-Jr. Derson da S. , Zukowsky-Tavares Cristina , Cardoso Thiago Gusmão , Milani Marco
Published: July 2022

ABSTRACT This article aims to analyze whether an organization's level of spirituality can mitigate professional stress. An online questionnaire was developed based on the following measures: A job stress scale and an organization's spirituality inventory, both were consolidated assessment applied in previous studies. This questionnaire was applied through a digital survey, strongly shared in social media and other channels, which obtained a total of 996 respondents from all over the country and with diverse demographic and professional characteristics. The data were standardized, coded and run on Stata IC v.15. in the multiple linear regression method. This study sought to enrich the knowledge on spirituality as a strategy for organizations, especially in crises situations, as Covid-19 pandemic. The results showed that the level of spirituality enhances the chance for organizations to take actions to deal with crises and reduces the professional stress in the context of uncertainties, as it is a benefit for mental health and well-being. This article could make important contributions presenting a quantitative analysis for a not usual subject in organization strategy: spirituality. It can bring new insights in people management studies, concluding that a company with greater spirituality is more likely to attract and retain people with the best talent.
Turismo, o setor de aviação e os reflexos da Covid-19 Um estudo comparativo sobre as companhias aéreas no Brasil: Azul, GOL e TAM
Authors: Silva Roberta Cristina da , Silva Andressa Quirino da
Published: July 2022

A crise econômico-financeira decorrente da pandemia da Covid-19 está longe de se pôr a termo e tem influenciado de maneira negativa muitos setores e atividades. O isolamento social implicou o cancelamento de viagens e, consequentemente, o ato de cancelar passagens aéreas. Ao longo desse período, iniciado em março de 2020, grandes companhias aéreas precisaram recorrer à utilização de capital de terceiros para enfrentar a severa crise em suas operacionalizações. Assim, a problemática desta pesquisa foi pautada na averiguação da realidade financeira vivida nesse momento pelas companhias aéreas. O objetivo geral teve como escopo verificar se as maiores empresas aéreas foram impactadas por reflexos de grau relevante quanto à crise financeira oriunda da pandemia. A proposta metodológica se desenvolveu mediante a análise de conteúdo com abordagem quantitativa-comparativa sobre as informações financeiras para os anos de 2019 (anterior à pandemia) e 2020. Os resultados evidenciam que as empresas analisadas foram impactadas negativamente pela pandemia e que tal circunstância justifica a necessidade da busca de capital de terceiros. Como contribuição, o estudo valida a realidade vivida pelas companhias aéreas no enfrentamento à crise, promovendo reflexão acerca do planejamento de ações assertivas para a recuperação desses impactos.
Alzheimer’s Disease: Treatment of Multi-Factorial Disorders with Multi-
Target Approach
Authors: Singh Palwinder , Kaur Baljit , Vivesh
Published: July 2022

Alzheimer’s Disease (AD) is a common neurodegenerative disorder that is almost incurable
with the existing therapeutic interventions. Due to the high-risk factors associated with
this disease, there is a global pursuit of new anti-AD agents. Herein, we explore the biochemical
pathways which are responsible for the initiation/propagation of the disease. It is observed that out
of the two isoforms of β-secretase, β-site amyloid precursor protein cleaving enzyme 1 (BACE1)
and β-site amyloid precursor protein cleaving enzyme 2 (BACE2) present in the brain, BACE1
plays the predominant role in the commencement of AD. Moreover, the catalytic activities of acetylcholinesterase
and butyrylcholinesterase regulate the concentration of neurotransmitters, and
they are needed to be kept under control during the signs of AD. Hence, these two enzymes also
serve as potential targets for the treatment of AD patients. Keeping in view the multifactorial nature
of the disease, we also reviewed the multitarget approach for the treatment of AD. It is tried
to identify the common structural features of those molecules which act on different cellular targets
during AD therapy.
Gender Differences in Treatment Delays, Management and Mortality
among Patients with Acute Coronary Syndrome: A Systematic Review and
Meta-analysis
Authors: Lunova Tetiana , Komorovsky Roman , Klishch Ivan
Published: July 2022

Background:

We aimed to provide a comprehensive overview of existing gender differences
in acute coronary syndrome (ACS), with respect to treatment delays, invasive management
of ACS, and short and long-term mortality in patients with ACS.

Methods:

We defined 37 observational studies (OSs) and 21 randomized trials (RCTs) that best
corresponded to our interests. OSs and RCTs were analyzed separately.

Results:

Women with ACS more often experienced delays in treatment compared to men (OR
1.43; 95% CI, 1.12-1.82) in RCTs. Female patients were less often treated invasively: RCTs (OR
0.87; 95% CI, 0.83-0.9), OSs: (OR 0.66; 95% CI, 0.63-0.68). Women had higher crude in-hospital
mortality (OR 1.56; 95% CI, 1.53-1.59) and 30-day mortality (OR 1.71; 95% CI, 1.22-2.4) in OSs
and (OR 2.74; 95% CI, 2.48-3.02) in RCTs. After adjustment for multiple covariates, gender difference
was attenuated: in-hospital mortality (OR 1.19; 95% CI, 1.17-1.2), 30-day mortality (OR
1.18; 95% CI, 1.12-1.24) in OSs. Unadjusted long-term mortality in women was higher than in
men (OR 1.41; 95% CI, 1.31-1.52) in RCTs and (OR 1.4; 95% CI, 1.3-1.5) in OSs.

Conclusion:

Women with ACS experience a delay in time to treatment more often than men. They
are also less likely to be treated invasively. Females have shown worse crude short-and long-term
all-cause mortality compared to males. However, after adjustment for multiple covariates, a less
significant gender difference has been observed. Considering the difference between crude and adjusted
mortality, we deem it reasonable to conduct further investigations on gender-related influence
of particular risk factors on the outcomes of ACS.
The Protective Role of Grape Seed in Obesity and Lipid Profile: An Updated
Narrative Overview of Preclinical and Clinical Studies
Authors: Samarghandian Saeed , Talebi Marjan , Esmaeeli Hadi , İlgün Selen , Talebi Mohsen , Farkhondeh Tahereh , Mishra Gaurav
Published: July 2022

Obesity and dyslipidemia are common disorders universally. According to the acquired
outcomes of recent studies, dietary supplementations which have great content of phenolic compounds
exert protective effects against obesity and dyslipidemia. Grape [Vitis vinifera] seeds are
considered attractive sources of phenolic compounds with anti-oxidative stress and anti-inflammatory
effects. There are also various experimental studies describing hepatoprotective, neuroprotective,
anti-aging, cardioprotective, and anti-carcinogenic effects of polyphenols isolated from grape
seed, highlighting the therapeutic and biological aspects of proanthocyanidins. The present review
article first discusses pharmacological, botanical, toxicological, and phytochemical characteristics
of Vitis vinifera seeds and afterward designates the protective properties which are attributed to the
intake of grape seeds in obesity and hyperlipidemia. Overall valuable and updated findings of this
study display that polyphenol of grape seeds has meaningful impacts on the regulation of lipid profile
levels and management of obesity.
Role of Macrophage in Type 2 Diabetes Mellitus: Macrophage Polarization
a New Paradigm for Treatment of Type 2 Diabetes Mellitus
Authors: Sur Debjeet , Banu Sarmin
Published: July 2022

Metabolic diseases such as type 2 diabetes mellitus are usually associated with meta-inflammation.
β-cell failure is a marked feature observed in the pathogenesis of type 2 diabetes mellitus.
Type 2 diabetes mellitus (T2DM) is a heterogeneous situation that is accompanied by not only defective
insulin secretion but also peripheral insulin resistance. β-cells are the primary organ for insulin
secretion; hence, it is crucial to maintain a significant β-cell mass in response to a variety of changes.
Insulin resistance is a chief cause of T2DM, leading to increased free fatty acid (FFA) levels, which
in turn elevates β-cell mass and insulin secretion as compensation for insulin insensitivity. It has recently
been established that amplified numbers of innate immune cells, cytokines, and chemokines
result in detrimental effects on islets in chronic conditions. Macrophage migration inhibitory factor
(MIF) is the lymphokine that prevents arbitrary migration of macrophages and assembles macrophages
at inflammatory loci. Inflammation is known to trigger monocytes to differentiate into macrophages.
Progress of complications associated with type 2 diabetes mellitus, as indicated through recent findings,
is also dependent on the buildup of macrophages in tissues vulnerable to diabetic injury. The
present article scientifically evaluates the present knowledge concerning the mechanisms of monocyte
and macrophage-mediated injury recruitment in complications associated with type 2 diabetes mellitus.
It also describes some of the established and experimental therapies that might bring about a reduction
in these inflammatory complications. Recent discoveries in the field of drug delivery have
facilitated phenotype-specific targeting of macrophages. This review highlights the pathophysiology
of type 2 diabetes mellitus, how macrophage induces type 2 diabetes mellitus and potential therapeutics
for type 2 diabetes mellitus via macrophage-specific delivery.
Surface Treatment of Flexible Barrier Film for Improved Stability of Organic Photovoltaic Mini Modules
Authors:   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Silva Clara L. e , Miranda Bárbara H.S. ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Vilela Maria L. ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Rodrigues Jair F. ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Cunha Thainá G. ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Dias Jhonatan A. ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Soares Gabriela A. ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Freitas Vinicius ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Vilaça Rodrigo de Q. ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Wouk Luana ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil, Bagnis Diego ,   CSEM Brasil, 2000 Sete, Horto Florestal, 31035-536, Belo Horizonte, Minas Gerais, Brazil
Published: July 2022

The lifetime and stability of organic photovoltaics (OPVs) are the key factors that influence the technology used to scale up and commercialize OPVs. High-performing and reliable devices are used to fabricate the devices of choice. Materials and methods that can be used to prevent the degradation of organic materials, enabling better OPV applications, are being increasingly researched in recent years. Herein, we present the surface modification process of a commercial, flexible barrier film based on polyethylene terephthalate (PET). A sol-gel deposition method was used to modify the surface. Two scalable coating techniques, spray- and bar-coating, were investigated as the processing methods. Treated films were optically, morphologically, and topologically characterized. The modification of the barrier film surface increased the surface hydrophobicity of the bar-coated and spray-coated treated films. This was validated by the contact angle measurements. OPV roll-to-roll (R2R) mini-modules with 4.2% power conversion efficiency were fabricated and encapsulated with the treated films. The lifetime and stability were assessed by conducting accelerated aging tests based on the ISOS-D-3 protocol. The spray-coating technique provided a more stable layer than the bar-coating technique, and the lifetime of the OPV modules encapsulated in spray-coated treated barrier films was increased. Surface modification has been demonstrated to be a promising approach for not only improving the barrier film properties (resulting in the improved lifetimes of the modules) but also reducing the extents of reflectance losses in the OPV modules post encapsulation.
Digital Phenotyping in Health Using Machine Learning Approaches: Scoping Review
Authors: Dlima Schenelle Dayna , Shevade Santosh , Menezes Sonia Rebecca , Ganju Aakash
Published: July 2022

Background

Digital phenotyping is the real-time collection of individual-level active and passive data from users in naturalistic and free-living settings via personal digital devices, such as mobile phones and wearable devices. Given the novelty of research in this field, there is heterogeneity in the clinical use cases, types of data collected, modes of data collection, data analysis methods, and outcomes measured.

Objective

The primary aim of this scoping review was to map the published research on digital phenotyping and to outline study characteristics, data collection and analysis methods, machine learning approaches, and future implications.

Methods

We utilized an a priori approach for the literature search and data extraction and charting process, guided by the PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-analyses Extension for Scoping Reviews). We identified relevant studies published in 2020, 2021, and 2022 on PubMed and Google Scholar using search terms related to digital phenotyping. The titles, abstracts, and keywords were screened during the first stage of the screening process, and the second stage involved screening the full texts of the shortlisted articles. We extracted and charted the descriptive characteristics of the final studies, which were countries of origin, study design, clinical areas, active and/or passive data collected, modes of data collection, data analysis approaches, and limitations.

Results

A total of 454 articles on PubMed and Google Scholar were identified through search terms associated with digital phenotyping, and 46 articles were deemed eligible for inclusion in this scoping review. Most studies evaluated wearable data and originated from North America. The most dominant study design was observational, followed by randomized trials, and most studies focused on psychiatric disorders, mental health disorders, and neurological diseases. A total of 7 studies used machine learning approaches for data analysis, with random forest, logistic regression, and support vector machines being the most common.

Conclusions

Our review provides foundational as well as application-oriented approaches toward digital phenotyping in health. Future work should focus on more prospective, longitudinal studies that include larger data sets from diverse populations, address privacy and ethical concerns around data collection from consumer technologies, and build “digital phenotypes” to personalize digital health interventions and treatment plans.
Negami: An Augmented Reality App for the Treatment of Spatial Neglect After Stroke (Preprint)
Authors: Stammler Britta , Flammer Kathrin , Schuster Thomas , Lambert Marian , Karnath Hans-Otto
Published: July 2022

BACKGROUND

A widely applied and effective rehabilitation method for patients experiencing spatial neglect after a stroke is “visual exploration training.” Patients improve their ipsilesional bias of attention and orientation by training exploration movements and search strategies toward the contralesional side of space. In this context, gamification can have a positive influence on motivation for treatment and thus on the success of treatment. In contrast to virtual reality applications, treatment enhancements through augmented reality (AR) have not yet been investigated, although they offer some advantages over virtual reality.

OBJECTIVE

This study aimed to develop an AR-based app (Negami) for the treatment of spatial neglect that combines visual exploration training with active, contralesionally oriented rotation of the eyes, head, and trunk.

METHODS

The app inserts a virtual element (origami bird) into the real space surrounding the patient, which the patient explores with the camera of a tablet. Subjective reports from healthy elderly participants (n=10) and patients with spatial neglect after stroke (n=10) who trained with the new Negami app were analyzed. Usability, side effects, and game experience were assessed by various questionnaires.

RESULTS

Training at the highest defined difficulty level was perceived as differently challenging but not as frustrating by the group of healthy elderly participants. The app was rated with high usability, hardly any side effects, high motivation, and entertainment. The group of patients with spatial neglect after stroke consistently evaluated the app positively on the dimensions of motivation, satisfaction, and fun.

CONCLUSIONS

The Negami app represents a promising extension by adding AR to traditional exploration training for spatial neglect. Through participants’ natural interaction with the physical surrounding environment during playful tasks, side effects as symptoms of cybersickness are minimized and patients’ motivation appeared to markedly increase. The use of AR in cognitive rehabilitation programs and the treatment of spatial neglect seems promising and should receive further investigation.
In Silico ADME/ Tox profile of tetrasubstitutedazadipyrrins
Authors:   Department of Chemistry, TuljaramChaturchand College, Baramati, Maharashtra (India), Bhondwe Rahul , Nandkhile Nishant ,   Department of Chemistry, TuljaramChaturchand College, Baramati, Maharashtra (India), Vanpure Sachin ,   Department of Chemistry, TuljaramChaturchand College, Baramati, Maharashtra (India)
Published: July 2022

We have explored the ADME (Absorption, Distribution, Metabolism and Excretion) profile of eight different derivatives of tetrasubstitutedaza-dipyrrins. Compound 1-9 are screened with the help of onlinewebtoolSwissADME. Studies were performed for pharmacokinetic, lipophilicity, water solubility, bioavailability and drug likeness properties. Compound 9 found to a optimum among all the compounds under investigation.
Chemically Synthesized Alq3 and Ni-doped Alq3 Nanorods for Spintronics Applications
Authors:   Department of Physics, Bareilly College, Bareilly (Affiliated to MJP Rohilkhand University, Bareilly)-243005 (India), KUMAR VEERENDRA , SINGH SUNDAR ,   Department of Physics, Bareilly College, Bareilly (Affiliated to MJP Rohilkhand University, Bareilly)-243005 (India)
Published: July 2022

In this research we demonstrate the synthesis of pristine tris(8-hydroxyquinoline) aluminium (Alq3) and nickel-doped Alq3 nanorods as well as their characterization. The thermal vapour transport method was used to synthesize nanomaterials in the morphology of nanorods. The surface morphology was studied using scanning electron microscopy (SEM). The structural properties were analyzed using X-ray diffraction. UV-Visible and photoluminescence (PL) spectroscopy were used to examine the optical characteristics. Doping of Ni introduced ferromagnetic properties in the Alq3 and also retained its semiconductor properties. Ni-doped Alq3 nanorods are useful for the development of spintronics devices.
FORMULATION AND CHARACTERIZATION OF JACKFRUIT LEAVES EXTRACT LOADED TRANSDERMAL FILMS
Authors: WIJAYA DINA PERMATA , FITRYA  , VERONIKA MELLIN
Published: July 2022

Objective: The aim of the study was the preparation and characterization of the transdermal films of jackfruit leaves extract.

Methods: A transdermal film loaded jackfruit leaves extract was formulated with chitosan as polymer and used variation concentration of plasticizer are combination from sorbitol and glycerol. The formulation was evaluated organoleptic, stability, folding resistance, uniformity of weight and thickness, water vapor transmission rate, retention capacity, FTIR spectrum, and drug release test.

Results: The results of the organoleptic test showed that the film was flexible, greenish-yellow in color, and had stable physical stability in the preparation. The increase in the concentration of plasticizer also had a significant effect (p<0.05) on the tensile strength test, uniformity of weight and film thickness, water vapor transmission rate, and retention capacity. The results of the FTIR test showed that there was a cross-linking interaction marked by the presence of a new peak at the wavenumber of 1556.31 cm-1. The best penetration test results are found in formula 2 with % penetration of 31.95% and J of 18.08 g cm-2 h-1.

Conclusion: All three formulas of transdermal films of jackfruit leaves extract have met the requirements and F2 showed best in vitro release than F1 and F3.
STANDARDIZATION AND A-GLYCOSIDASE INHIBITION OF EXTRACTS AND NANOPARTICLE EXTRACT OF KEMBANG BULAN LEAVES (TITHONIA DIVERSIVOLIA (HAMSLEY) A. GRAY)
Authors: DJAMIL RATNA , RAHMAT DENI , AZKIA HILMA , PRATAMI DIAH KARTIKA , SWANDINY GREESTY FINOTORY
Published: July 2022

Objective: The purpose of this study was the determination of the quality parameters of the antidiabetic activity of 70% ethanol extract and Kembang Bulan leaf nanoparticle extract.

Methods: Kembang Bulan powder was macerated kinetic with 70% ethanol, evaporated until a thick extract was obtained using a rotary evaporator, then specific and non-specific parameters were determined, and phytochemical screening was done. The extract was tested for anti-diabetic activity in vitro using the α-glucosidase enzyme.

Results: Phytochemical screening results show the presence of flavonoids, saponins, tannins, essential oils, coumarin, steroids, and triterpenoids. The results of quality parameter examination showed that the extract had a thick consistency, blackish-brown color, aromatic odor, 75.20% dissolved compound and 71.97% dissolved compound in ethanol, 9.65% drying shrinkage, 8.73% moisture content, the remaining solvent is 0.43%, the total ash content is 7.12%, the acid insoluble ash content is 0.93%, the Pb level is 0.1167 mg/kg BW, the Cd level is 0.0620 mg/kg BW, the ALT microbial contamination is 0.6827x and Mold and yeast contamination 0.156x. Total flavonoid levels were 1.15%.

Conclusion: The test results can be concluded that the 70% ethanol extract and nanoparticle extracts from Kembang Bulan leaves can inhibit the activity of the αglucosidase enzyme and the inhibitory results obtained by the nanoparticle extract are greater than the 70% ethanol extract.
FORMULATION AND ACTIVITY TEST OF SUNFLOWER OIL (HELIANTHUS ANNUUS L.) LIQUID SOAP AS ANTI ACNE
Authors: ISKANDAR BENNI , PUTRI RANI SEPTIANA , NOVITA GRESSY , SURBOYO MEIRCURIUS DWI CONDRO , LENY  , LEE CHING-KUO
Published: July 2022

Objective: This study aims to obtain a liquid soap containing sunflower oil which has a good physical characteristics and stability, also has potential as an antibacterial towards acne bacteria.

Methods: Sunflower oil is formulated into liquid facial wash with various concentrations 10% (F1); 15% (F2); and 20% (F3). Evaluation of preparations includes organoleptic test, pH value, specific gravity, viscosity, foaming ability, foam stability, freeze and thaw stability, and antibacterial activity against Propionibacterium acnes which causes acne by using the disc diffusion method. Data obtained was analyzed using Kruskal Wallis statistical test, One Way ANOVA, and descriptive test.

Results: Based on the results of the evaluation of the preparations, it was found that the organoleptic examination of F1, F2, and F3 liquid soap preparations had a thick liquid form, milky white in color, with the smell of rose. Liquid facial wash preparations of F1, F2, and F3 meet the evaluation requirements of pH, specific gravity, viscosity, ability to form foam, stable during storage in various degrees. Based on the analysis of the One Way ANOVA statistical test, there was a significant difference (p<0.05) in the diameter of the inhibition zone between each group of formulas.

Conclusion: It was concluded that the liquid facial wash preparations of sunflower oil F1, F2, and F3 were physically stable during storage, and based on the antibacterial activity test it was known that F3 had the greatest bacterial inhibition with a strong inhibition category (32.19±0.36 mm)
ISOLATION, IDENTIFICATION, AND ANTIBACTERIAL OF AMENTOFLAVONE FROM GARCINIA LATISSIMA MIQ. LEAVES
Authors: AMBARWATI NENENG SITI SILFI , ELYA BERNA , MALIK AMARILA , HANAFI MUHAMMAD , AWANG MUHAMAD SHARUL NIZAM
Published: July 2022

Objective: This study aimed to isolate and identify the Bacillus subtilis antibacterial compound present in the leaves of the Garcinia latissima Miq.

Methods: The extracts were obtained by maceration successively, and the active extract was fractionated by column chromatography. The isolation of the most active fraction was performed by open column chromatography and preparative thin-layer chromatography. The isolate antibacterial assay against Bacillus subtilis by microdilution method. The compound structure of the isolate was identified by the nuclear magnetic resonance method.

Results: The most active extract of the extracts from Garcinia latissima Miq. leaves against Bacillus subtilis are the methanol extract. The most active fractions of the fractions from G. latissima Miq. Leaves methanolic extract was isolated. The active isolate was identified as Amentoflavone.

Conclusion: G. latissima Miq. leaves had the potential to be used as antibacterial medicinal herbs and one of the isolates of G. latissima Miq. is amentoflavone (active against B. Subtilis).
FORMULATION GEL SELF NANOEMULSIFYING DRUG DELIVERY SYSTEM (SNEDDS) ALPHA-BISABOLOL AS ANTIOXIDANT
Authors: RAMADHAN JANUAR AKBAR , NOOR SITI UMRAH
Published: July 2022

Objective: Alpha-Bisabolol is monocyclic sesquiterpene alcohol obtained from the distillation of chamomile flowers (Matricaria chamomilla), that has many uses in the pharmaceutical industry, one of them is an antioxidant. Alpha-Bisabolol was formulated into Self Nanoemulsifying Drug Delivery System (SNEDDS) to protect it from oxidation reactions in skin metabolism and to help penetrate it to the dermis layer where it works. The purpose of this study is to develop the use of Alpha-Bisabolol as an antioxidant that is formulated into SNEDDS gel dosage form. Optimization of SNEDDS was carried out on four formulas with a different comparison of surfactant and use of percent transmittance as the parameter.

Methods: Optimum SNEDDS is then tested for characterization, including dispersibility test, particle size, polydispersity index (PDI), zeta potential, and freeze-thaw cycle. The result for SNEDDS optimization shows that formula 4 produces the highest percent transmittance of 99.44±0.04%.

Results: Optimum formula that was characterized resulting clear nanoemulsion with an emulsification time 29.64±0.09 second, with the particle size of 16.74 nm, PDI of 0.121, and zeta potential of-18.7 mV also shows good stability after freeze-thaw cycle test for three cycles. Optimum SNEDDS then formulate to gel form. Based on the result of the physical and chemical quality evaluation test for Alpha-Bisabolol SNEDDS gel, it was found that SNEDDS gel was homogeneous with a clear yellowish appearance, odorless with semi-solid form, had viscosity 180±2 cP with plastic thixotropy flow properties, spreadability 2937.7691±2.40 mm2 and pH 5.55±0.015.

Conclusion: It can be concluded that Alpha-Bisabolol and SNEDDS Alpha-Bisabolol gel have antioxidant activity with IC50 of 123.78 g/ml and 371.44 g/ml, respectively.
PRELIMINARY STUDY FOR COVID-19 DRUG DISCOVERY OF 30 PHYTOCHEMICAL COMPOUNDS FROM TETRAGONULA SP. PROPOLIS AS PAK1 INHIBITOR THROUGH MOLECULAR DOCKING
Authors: ASIH SAFIRA CANDRA , SAHLAN MUHAMAD , NASIKIN MOHAMMAD
Published: July 2022

Objective: This study aims to evaluate 30 phytochemical compounds from Tetragonula sp. propolis as a PAK1 inhibitor using molecular docking.

Methods: Thirty propolis compounds were initially confirmed before docking to comply with Lipinski rules. This simulation was performed against PAK1 using AutodockVina, while interaction profile visualization was conducted between the ligand and receptor through Ligplot+and PyMol.

Results: Based on the docking score, inhibition constants, and interaction profile analyses, glyurallin B, glyasperin A, and broussoflavonol F were found to be the most potent compounds used as PAK1 inhibitors. According to several literature studies, the propolis compounds were synergistic, leading to adequate collective utilization.

Conclusion: These results implicated the potentials of Tetragonula sp. propolis as a therapeutic agent against COVID-19; however, further studies are still needed.
TO EVALUATE THE EFFICACY, SAFETY AND TOLERABILITY OF ORAL PROPRANOLOL COMPARISON WITH ORAL AMITRIPTYLINE FOR MIGRAINE PROPHYLAXIS
Authors: JYOTHI DAKURI , JAJU SHUBHAM , KARUNASREE N.
Published: July 2022

Objective: Treatment of migraine is both therapeutic and prophylactic. Prophylactic therapy is used to prevent further attacks. Amitriptyline and Propranolol are the most commonly used drugs for prophylactic therapy. The main objective of the study is to compare the efficacy, safety, and tolerability of Amitriptyline and Propranolol.
Methods: A Prospective, Comparative, open-label study was taken up in the department of neurology, Osmania General Hospital, Hyderabad. 80 patients were randomly allocated into two groups. GROUP A with 40 patients received Tab. Amitriptyline 10 mg once daily, GROUP B with 40 patients received Tab. Propranolol 20 mg once daily at night for a period of 3 mo. The severity of the headache was measured by a 4-point pain scale and patients self–assessment migraine diary at the end of the 4th, 8th, and 12th weeks to assess treatment efficacy.
Results: The mean number of attacks in the Amitriptyline and Propranolol group decreased as the duration of treatment increased. The decrease was markedly significant in the Amitriptyline group. There was a significant reduction in the severity of attacks among the Amitriptyline group (P=<0.0000001).
Conclusion: In this study, the mean number of migraine attacks in the Amitriptyline and the Propranolol group decreased as the duration of treatment increased. The decrease was markedly significant in the Amitriptyline group. Thus, Amitriptyline is more effective in decreasing Amitriptyline is more effective than Propranolol in decreasing the number, duration, and severity of attacks.
Screening for cross-cultural adaptations of the Patient’s Dignity Inventory
Authors: Cavalcanti Alessandra do Nascimento , Pinto Karina Danielly Cavalcanti , Maia Eulália Maria Chaves
Published: July 2022

Cross-cultural adaptation is a process that involves the transfer of knowledge between different cultures. Therefore, for a psychological instrument to be used in another country, for example, it is necessary to follow methodological rigors for an effective final model. In the field of oncology, research on the concept of dignity is incipient in most of the countries and one of the precursors of this concept was the Canadian psychiatrist, Harvey Chochinov. A model called the Dignity Model was developed and resulted in an inventory (Patient Dignity Inventory). The objective of this research is to carry out a screening on the cross-cultural adaptation studies of the Patient's Dignity Inventory. It is an integrative literature review to verify the main studies published databases about validation of the Patient Dignity Inventory. MEDLINE, LILACS, Scielo and Google Scholar databases were used to track adaptation studies. The keywords "Patient Dignity Inventory" AND "Validation" OR "Cross Cultural" were used for the collection of articles. In the initial results, 121 articles were found. After applying all filters, 19 articles were found within the criteria selected for review. It was noticed that most of the studies used rigorous methods, resulting in inventories with satisfactory psychometric properties for use in another culture.
Wind Resource Assessment: Optimizing the Weibull Distribution Curve
Authors: Dogra Arundhati
Published: July 2022

Abstract: In this paper, it was analyze the wind speed characteristics and provide projections of optimal wind resources by comparing data at different hub heights using wind power law. We have acquired data from an operational project site in the western part of India using data points acquired from the site from August 2017 to February 2018.Weibull distribution probability distribution function and cumulative distribution function for wind speed and other parameters involved in an accurate wind resource assessment methodology. To predict wind regimes, the Weibull probability function is commonly used. A comparison of alternative methods for estimating Weibull parameters of a wind regime is presented in this research. For the estimation, five alternative methods are discussed and employed. The study examined wind speed time series data at two sites over the course of a year. Although all five methods produce similar results when plotting error versus wind speed, the standard deviation method produces the best results.
Stagewise Classification of Chronic Kidney Disease and Diet Plan Recommendation
Authors: Taranum Dr. Ayesha
Published: July 2022

Abstract: Chronic kidney disease means gradual loss in functioning of kidney. Undiagnosed Chronic Kidney Disease can be identified, predicting the patient condition and its prevention with machine Learning Techniques. Accurate analytical models can be formed by medical practices, which decreases consequences hence gradually progresses specifications. To estimate Chronic Kidney Disease and to identify the stages in it. Dietary plan will be recommended based on the stages of Chronic Kidney Disease. There are no symptoms of Chronic Kidney Disease at earlier stages and if the disease remains unrectified then it can lead to kidney failure. Manual examination of Chronic Kidney Disease is a possible solution however it is dependent on human errors. Detecting Chronic Kidney Disease at early stage can help doctor to give better medication and patient may recovers soon.
Analysis on Text Summarization
Authors: Divekar Akash
Published: July 2022

Abstract: As we enter the 21st century, with the advent of mobile phones and access to information stores, we seem to be surrounded by more information, less time, or the ability to process it. The creation of automated summaries was a clever human solution to this complex problem. However, the application of this solution was very complicated. In fact, there are a number of problems that need to be addressed before the promises of an automated text can be fully realized. Basically, it is necessary to understand how people summarize the text and build a system based on that. However, people are different in their thinking and interpretation that it is difficult to make a "gold standard" summary in which product summaries will be tested. In this paper, we will discuss the basic concepts of this article by providing the most appropriate definitions, characterization, types and two different methods of automatic text abstraction: extraction and extraction. Special attention is given to the method of extraction. It consists of selecting sentences and paragraphs that are important in the original text and combining them into a short form. It is mentally simple and easy to use
Survey Paper for Real Time Car Driver Drowsiness Detection using Machine Learning Approach
Authors: More Prof. Manisha
Published: July 2022

Abstract: Tiredness is a way wherein one level of mindfulness is decreased due to lacking of rest or weariness and it might cause the driver fall into rest unobtrusively. A Drowsy or lethargic driver can't decide while he/she can have a crazy rest. Nod off pulverizes are exceptionally outrageous as far as injury.Recent insights gauge that every year 1,200 passings and 76,000 wounds can be caused to fatigue or sluggishness related crashes. Over 25% of interstate car crashes are caused as consequence of driver weariness. Decrease the gamble of a mishap by advance notice the driver of his/her tiredness. This undertaking is fundamentally founded on four parts 1) Face and Eye identification: Performs scale invariant location utilizing Haar Cascade Classifier perform through a webcam. 2) Eye highlight extraction: Eye highlights are removed utilizing Hough Circle and 3) Extract single eye 4) Edge location and perform tiredness discovery on it. In the proposed technique, following the face identification step, the facial parts those are more significant and considered as the best for tiredness, are removed and followed in video succession outlines. The framework has been tried and carried out in a genuine climate. The commitment work is when tiredness recognized, after it will give alert admonition sign to the driver.