bluuebunny/crossref_metadata_2025 huggingface dataset:
PSIKOLOGI DAN PASTORAL KONSELING DALAM PENDIDIKAN ORANG DEWASA
Authors: Manoppo Laima Melanny , Lahose Geri Harkel , Raintung Agnes Beatrix Jackline , Muliku Efron
Published: September 2024

This article discusses the important role of developmental psychology in adult education, especially in the context of Christian education. Understanding the characteristics of adult development, such as cognitive, social, emotional, and spiritual development, is essential for Christian educators to design effective and relevant educational programs. This article describes several principles of adult education based on developmental psychology, such as adult-centered learning, relevant learning, collaborative learning, and sustainable learning. Furthermore, this article discusses how the principles of Christian education can be integrated with developmental psychology to create holistic and meaningful educational programs for adults. The research method used is literature with data collection techniques that identify sources relevant to the research topic. This can be books, journal articles, research reports, theses, dissertations and other documents that can be accessed in the library or online. Data Collection: After identifying relevant sources, the researcher collects data by reading and recording important information that is in accordance with the research objectives. Data Classification: The data that has been collected is then classified based on certain themes or topics to make the analysis process easier. Data Analysis: Data that has been classified is then explained to find patterns, concepts, or theories that are relevant to the research topic. This analysis can be descriptive analysis, comparative analysis, or critical analysis. Synthesis and Interpretation: The results of data analysis are then synthesized and interpreted to provide a deeper understanding of the research topic. Researchers connect the findings obtained with existing theories or concepts to answer research questions.
Effets de résonance entre Adolphe de Benjamin Constant et Le Renoncement de Philippe Vilain
Authors: Mura-Brunel Aline
Published: September 2024

Il s’est agi de montrer dans quelle mesure l’oeuvre de Philippe Vilain, dotée d’une double identité, relève autant de l’autofiction que du roman d’analyse. A ce titre, elle s’inscrit dans la lignée de romans publiés au XIXe siècle, tout en appartenant pleinement au paysage littéraire contemporain.

Dans ce cadre, j’ai choisi d’explorer les effets de résonance entre deux textes en particulier : Adolphe de Benjamin Constant et Le Renoncement de Philippe Vilain – et ce, d’un triple point de vue : les filiations intermittentes, les effets du silence, la force des digressions.

Afin de proposer une perspective plus large, je me suis référée à plusieurs autres romans de Philippe Vilain (tels que Pas son genre, Une idée de l’enfer, L’Étreinte, Un matin d’hiver et Paris l’après-midi) ainsi qu’à ses ouvrages critiques ; et, ce faisant, j’ai tenté d’établir le statut d’une fiction pensive.
Philippe Vilain, à la recherche de l’amour perdu…
Authors: Cortey-Lemaire Mathilde
Published: September 2024

Le narrateur des romans de Philippe Vilain est toujours soit un perdant passif de l’amour, dépossédé de l’être qu’il a aimé, soit un perdeur actif : il ruine la relation amoureuse qui s’est construite. Mais que perd-il ? Ne perd-il que l’objet de son amour ? Se perd-il lui même ? S’agit-il de perdre un amour pour mieux retrouver l’amour ? pour mieux se retrouver soi ? Ou s’agit-il de retrouver autre chose et quoi ? Vers quelle vérité conduit cette recherche, cette quête, infiniment recommencée, cette tentative d’épuisement de ce topos. Les amours perdues, comme le temps perdu, quand elles sont retrouvées dans la mise en récit littéraire, redonnent, finalement, à l’amour, tout son absolu, toute sa puissance et toute sa grandeur : l’amour perdu et retrouvé, c’est le fondement de la création et de la Littérature selon Philippe Vilain.
Un albatros dans la prose : notes sur Confession d’un timide de Philippe Vilain
Authors: Chaudier Stéphane
Published: September 2024

Un écrivain peut-il être timide ? Une oeuvre qui s’abreuve à la source vive du moi peut-elle être l’oeuvre d’un timide ? Peut-on imaginer un timide publier une confession où il se déclare, à la face du monde, timide ? Répondre oui à ces questions, c’est ouvrir la voie au paradoxe qui fait l’objet de cette étude : pour Philippe Vilain, la littérature est le discours par lequel l’homme timide retourne comme un gant la passion qui l’empêche de parler ; ce qu’on ne peut pas dire, il faudra donc l’écrire. En entreprenant une enquête sur la timidité (passion intime s’il en est), en s’efforçant de la décrire, de la définir, en faisant l’inventaire de tout ce dont elle prive — Philippe Vilain interroge le secret de son art : une écriture classique, un style tenu, une prose sobre et tendue sont sa manière d’inscrire la timidité au coeur de l’oeuvre, de faire rayonner la pudeur de la langue dans l’impudeur du livre.
Philippe Vilain ou la logique du rêve
Authors: Boulier Philippe
Published: September 2024

Il y a une ambivalence de l’amour. D’un côté, aimer est un acte qui relève d’un choix, d’une attitude ou d’une décision. C’est un acte de la volonté. D’un autre côté, l’amour est une passion, un sentiment ou un affect. L’écriture de Philippe Vilain exprime la synthèse de ces deux aspects, à savoir la rêverie, le fantasme, le rêve éveillé. Il s’agit de cette activité passive de l’imagination. Ce rêve éveillé, cette hallucination du souvenir passée au crible de l’intelligence critique s’exprime dans une écriture qui plonge dans un temps indifférencié : l’imparfait. Le style de Philippe Vilain manifeste notamment deux problèmes fondamentaux touchant chacun des deux aspects de l’amour. Premièrement, l’amour prend toujours la forme d’une contingence, d’un hasard ou d’un ensemble de circonstances arbitraires qui font la rencontre de deux personnes et, semble-t-il, de deux libertés qui se choisissent mutuellement. Toutefois, une logique implacable transforme cette apparence fortuite en fatalité, qui semble exclure le choix. Deuxièmement, l’amour est une réalité ressentie, mais c’est une réalité qui vit peut-être d’illusions.
Penser la disparition : la question du disparêtre dans les romans de Philippe Vilain
Authors: Surmonte Emilia
Published: September 2024

La « disparition » de l’ « autre », sous diverses formes, que l’on analysera dans ce contexte, constitue une constante de l’oeuvre de Philippe Vilain. Elle s’accompagne d’une autre forme de disparition, qui découle de la relation complexe que cet écrivain établit avec les modalités expressives de la subjectivité, source de réflexions critiques dans ses essais et d’expérimentations narratives de la parole des « je » protagonistes. À partir des premières épreuves plus explicitement autofictionnelles, ses subjectivités narratives évoluent et se multiplient, fragmentations d’un moi auctorial émotionnel, intellectuel et culturel, aux multiples facettes. Une analyse et une réflexion critique sur ces disparitions d’êtres, fictifs et auctoriaux, est proposée dans cet article.
Ca2+ channel and active zone protein abundance intersects with input-specific synapse organization to shape functional synaptic diversity
Authors: Medeiros Audrey T , Gratz Scott J , Delgado Ambar , Ritt Jason T , O'Connor-Giles Kate M
Published: September 2024

Synaptic heterogeneity is a hallmark of nervous systems that enables complex and adaptable communication in neural circuits. To understand circuit function, it is thus critical to determine the factors that contribute to the functional diversity of synapses. We investigated the contributions of voltage-gated calcium channel (VGCC) abundance, spatial organization, and subunit composition to synapse diversity among and between synapses formed by two closely related Drosophila glutamatergic motor neurons with distinct neurotransmitter release probabilities (Pr). Surprisingly, VGCC levels are highly predictive of heterogeneous Pr among individual synapses of either low- or high-Pr inputs, but not between inputs. We find that the same number of VGCCs are more densely organized at high-Pr synapses, consistent with tighter VGCC-synaptic vesicle coupling. We generated endogenously tagged lines to investigate VGCC subunits in vivo and found that the α2δ–3 subunit Straightjacket along with the CAST/ELKS active zone (AZ) protein Bruchpilot, both key regulators of VGCCs, are less abundant at high-Pr inputs, yet positively correlate with Pr among synapses formed by either input. Consistently, both Straightjacket and Bruchpilot levels are dynamically increased across AZs of both inputs when neurotransmitter release is potentiated to maintain stable communication following glutamate receptor inhibition. Together, these findings suggest a model in which VGCC and AZ protein abundance intersects with input-specific spatial and molecular organization to shape the functional diversity of synapses.
OVO positively regulates essential maternal pathways by binding near the transcriptional start sites in the Drosophila female germline
Authors: Benner Leif , Muron Savannah , Gomez Jillian G , Oliver Brian
Published: September 2024

Differentiation of female germline stem cells into a mature oocyte includes the expression of RNAs and proteins that drive early embryonic development in Drosophila. We have little insight into what activates the expression of these maternal factors. One candidate is the zinc-finger protein OVO. OVO is required for female germline viability and has been shown to positively regulate its own expression, as well as a downstream target, ovarian tumor, by binding to the transcriptional start site (TSS). To find additional OVO targets in the female germline and further elucidate OVO’s role in oocyte development, we performed ChIP-seq to determine genome-wide OVO occupancy, as well as RNA-seq comparing hypomorphic and wild type rescue ovo alleles. OVO preferentially binds in close proximity to target TSSs genome-wide, is associated with open chromatin, transcriptionally active histone marks, and OVO-dependent expression. Motif enrichment analysis on OVO ChIP peaks identified a 5’-TAACNGT-3’ OVO DNA binding motif spatially enriched near TSSs. However, the OVO DNA binding motif does not exhibit precise motif spacing relative to the TSS characteristic of RNA polymerase II complex binding core promoter elements. Integrated genomics analysis showed that 525 genes that are bound and increase in expression downstream of OVO are known to be essential maternally expressed genes. These include genes involved in anterior/posterior/germ plasm specification (bcd, exu, swa, osk, nos, aub, pgc, gcl), egg activation (png, plu, gnu, wisp, C(3)g, mtrm), translational regulation (cup, orb, bru1, me31B), and vitelline membrane formation (fs(1)N, fs(1)M3, clos). This suggests that OVO is a master transcriptional regulator of oocyte development and is responsible for the expression of structural components of the egg as well as maternally provided RNAs that are required for early embryonic development.
The common Sting1 HAQ, AQ alleles rescue CD4 T cellpenia, restore T-regs, and prevent SAVI (N153S) inflammatory disease in mice
Authors: Aybar-Torres Alexandra a , Saldarriaga Lennon A , Pham Ann T , Emtiazjoo Amir M , Sharma Ashish K , Bryant Andrew j , Jin Lei
Published: September 2024

The significance of STING1 gene in tissue inflammation and cancer immunotherapy has been increasingly recognized. Intriguingly, common human STING1 alleles R71H-G230A-R293Q (HAQ) and G230A-R293Q (AQ) are carried by ~60% of East Asians and ~40% of Africans, respectively. Here, we examine the modulatory effects of HAQ, AQ alleles on STING-associated vasculopathy with onset in infancy (SAVI), an autosomal dominant, fatal inflammatory disease caused by gain-of-function human STING1 mutations. CD4 T cellpenia is evident in SAVI patients and mouse models. Using Sting1 knock-in mice expressing common human STING1 alleles HAQ, AQ, and Q293, we found that HAQ, AQ, and Q293 splenocytes resist STING1-mediated cell death ex vivo, establishing a critical role of STING1 residue 293 in cell death. The HAQ/SAVI(N153S) and AQ/SAVI(N153S) mice did not have CD4 T cellpenia. The HAQ/SAVI(N153S), AQ/SAVI(N153S) mice have more (~10-fold, ~20-fold, respectively) T-regs than WT/SAVI(N153S) mice. Remarkably, while they have comparable TBK1, IRF3, and NFκB activation as the WT/SAVI, the AQ/SAVI mice have no tissue inflammation, regular body weight, and normal lifespan. We propose that STING1 activation promotes tissue inflammation by depleting T-regs cells in vivo. Billions of modern humans have the dominant HAQ, AQ alleles. STING1 research and STING1-targeting immunotherapy should consider STING1 heterogeneity in humans.
Gamma-aminobutyric acid elicits H2O2 signalling and promotes wheat seed germination under combined salt and heat stress
Authors: Yu Song , Lian Zhihan , Yu Lihe , Guo Wei , Zhang Chunyu , Zhang Yifei
Published: September 2024

Background

In the realm of wheat seed germination, abiotic stresses such as salinity and high temperature have been shown to hinder the process. These stresses can lead to the production of reactive oxygen species, which, within a certain concentration range, may actually facilitate seed germination. γ-aminobutyric acid (GABA), a non-protein amino acid, serves as a crucial signaling molecule in the promotion of seed germination. Nevertheless, the potential of GABA to regulate seed germination under the simultaneous stress of heat and salinity remains unexplored in current literature.

Methods

This study employed observational methods to assess seed germination rate (GR), physiological methods to measure H2O2 content, and the activities of glutamate decarboxylase (GAD), NADPH oxidase (NOX), superoxide dismutase (SOD), and catalase (CAT). The levels of ABA and GABA were quantified using high-performance liquid chromatography technology. Furthermore, quantitative real-time PCR technology was utilized to analyze the expression levels of two genes encoding antioxidant enzymes, MnSOD and CAT.

Results

The findings indicated that combined stress (30 °C + 50 mM NaCl) decreased the GR of wheat seeds to about 21%, while treatment with 2 mM GABA increased the GR to about 48%. However, the stimulatory effect of GABA was mitigated by the presence of ABA, dimethylthiourea, and NOX inhibitor, but was strengthened by H2O2, antioxidant enzyme inhibitor, fluridone, and gibberellin. In comparison to the control group (20 °C + 0 mM NaCl), this combined stress led to elevated levels of ABA, reduced GAD and NOX activity, and a decrease in H2O2 and GABA content. Further investigation revealed that this combined stress significantly suppressed the activity of superoxide dismutase (SOD) and catalase (CAT), as well as downregulated the gene expression levels of MnSOD and CAT. However, the study demonstrates that exogenous GABA effectively reversed the inhibitory effects of combined stress on wheat seed germination. These findings suggest that GABA-induced NOX-mediated H2O2 signalling plays a crucial role in mitigating the adverse impact of combined stress on wheat seed germination. This research holds significant theoretical and practical implications for the regulation of crop seed germination by GABA under conditions of combined stress.
Molecular farming expression of recombinant fusion proteins applied to skincare strategies
Authors: Yu Guangdong , Zhao Wengang , Wang Yunpeng , Xu Nuo
Published: September 2024

This review discusses the current research progress in molecular farming technology in the field of skincare, with an emphasis on molecular farming expression strategies. The strategies of transdermal drug delivery and their advantages are also highlighted. The expression of cosmetically relevant fused proteins has become an important way to enhance the efficacy of the proteins. Therefore, we also discuss the feasibility and strategies for expressing fusion proteins in A. thaliana, specifically the fusion of Epidermal growth factor (EGF) to a cell-penetrating peptide (CPP), in which the production can be greatly enhanced via plant expression systems since these systems offer higher biosecurity, flexibility, and expansibility than prokaryotic, animal and mammalian expression systems. While the fusion of EGF to CCP can enhance its transdermal ability, the effects of the fusion protein on skin repair, melasma, whitening, and anti-aging are poorly explored. Beyond this, fusing proteins with transdermal peptides presents multiple possibilities for the development of tissue repair and regeneration therapeutics, as well as cosmetics and beauty products. As certain plant extracts are known to contain proteins beneficial for skin health, the expression of these proteins in plant systems will better maintain their integrity and biological activities, thereby facilitating the development of more effective skincare products.
SNARC-like effect for tempo is consistent for fast and full tempo ranges but still controversial for slow tempo range
Authors: Mariconda Alberto , Murgia Mauro , De Tommaso Matteo , Agostini Tiziano , Prpic Valter
Published: September 2024

Recent evidence suggested the existence of a spatial associations for music tempo with faster left-hand responses to relatively slow tempos and faster right-hand responses to relatively fast tempos. We refer to a study that systematically explored these spatial associations across different tempo ranges, revealed a clear effect only in the fast tempo range (DOI 10.3758/s13414-019-01945-8). The present study further investigated whether a spatial association exists across different tempo ranges (i.e., “full”, “slow” or “fast” tempo range). In particular, the present study was conducted aiming (1) to test the spatial associations for tempo in the full tempo range (Experiment 1) and (2) to further investigate the occurrence of this spatial associations in the slow and fast tempo ranges (Experiment 2). Experiment 1 revealed a spatial association for tempo occurs in the full tempo range (40–200 bpm). Experiment 2 confirmed this association in the fast tempo range (133–201 bpm) but showed contradictory results in the slow tempo range (40–104 bpm). This suggests that a spatial association is plausible in the slow tempo range, although further research is needed to clarify this phenomenon.
Effects of moderate physical activity on diabetic adhesive capsulitis: a randomized clinical trial
Authors: Sheikh Raheela Kanwal , Toseef Amna , Omer Aadil , Aftab Anam , Haider Khan Muhammad Manan , Ayaz Saeed Bin , Althomli Omar , Razzaq Aisha , Khokhar Samra , Jabbar Nazia , Awan Waqar Ahmed
Published: September 2024

Background

Moderate physical activity (MPA) has proven advantages for glycemic control, cardiovascular health, and functional independence. However, physical activity is not part of routine conventional physical therapy (CPT) in managing diabetic adhesive capsulitis patients.

Objective

To determine the effects of moderate MPA on diabetic adhesive capsulitis (AC).

Methodology

A randomized control trial was conducted at the Combined Military Hospital (CMH), Muzaffarabad, Pakistan from March 2022 to October 2022. A total of n = 44 patients with diabetic AC, aged 40 to 65 years, HbA1c > 6.5% were enrolled. Group A received MPA and CPT, while Group B only received CPT for six weeks. The upper extremity function, pain, and range of motion were assessed at baseline, third week, and sixth week through the disability of arm, shoulder, and hand (DASH) questionnaire, numeric pain rating scale (NPRSS), and goniometer respectively.

Results

The NPRS score and ROMs showed significant improvement (p < 0.05) in group A compared to group B with a large effect size. When comparing the mean difference of the DASH score (73 + 7.21 vs. 57.9 + 12.64, p < 0.001, Cohen’s d = 1.46) was significantly improved with large effect size in group A as compared to group B.

Conclusion

MPA along with CPT has positive effects on patient pain, range of motion, and disability in patients with diabetic adhesive capsulitis.
ANXA2 promotes osteogenic differentiation and inhibits cellular senescence of periodontal ligament cells (PDLCs) in high glucose conditions
Authors: Huang Yanlin , Wang Jiaye , Jiang Chunhui , Zheng Minghe , Han Mingfang , Fang Qian , Liu Yizhao , Li Ru , Zhong Liangjun , Li Zehui
Published: September 2024

Background

Periodontal ligament cells (PDLCs) are a major component of the periodontal ligament and have an important role in the regeneration of periodontal tissue and maintenance of homeostasis. High glucose can affect the activity and function of PDLCs in a variety of ways; therefore, it is particularly important to find ways to alleviate the effects of high glucose on PDLCs. Annexin A2 (ANXA2) is a calcium- and phospholipid-binding protein involved in a variety of cellular functions and processes, including cellular cytokinesis, cytophagy, migration, and proliferation.

Aim

The aim of this study was to exploring whether ANXA2 attenuates the deleterious effects of high glucose on PDLCs and promotes osteogenic differentiation capacity.

Methods and results

Osteogenic differentiation potential, cellular senescence, oxidative stress, and cellular autophagy were detected. Culturing PDLCs with medium containing different glucose concentrations (CTRL, 8 mM, 10 mM, 25 mM, and 40 mM) revealed that high glucose decreased the protein expression of ANXA2 (p < 0.0001). In addition, high glucose decreased the osteogenic differentiation potential of PDLCs as evidenced by decreased calcium deposition (p = 0.0003), lowered ALP activity (p = 0.0010), and a decline in the expression of osteogenesis-related genes (p = 0.0008). Moreover, β-Galactosidase staining and expression of p16, p21 and p53 genes showed that it increased cellular senescence in PDLCs (p < 0.0001). Meanwhile high glucose increased oxidative stress in PDLCs as shown by ROS (p < 0.0001). However, these damages caused by high glucose were inhibited after the addition of 1 µM recombinant ANXA2 (rANXA2), and we found that rANXA2 enhanced autophagy in PDLCs under high glucose conditions.

Conclusions and discussion

Therefore, our present study demonstrates that alterations in ANXA2 under high glucose conditions may be a factor in the decreased osteogenic differentiation potential of PDLCs. Meanwhile, ANXA2 is associated with autophagy, oxidative stress, and cellular senescence under high glucose conditions.
Value of preoperative prognostic nutritional index combined with NT-proBNP in predicting acute kidney injury of congenital heart disease children
Authors: Qiao Yan , Lv Zhenqian , Liu Xiaojun , Zhou Baoguo , Wang Haiping , Wang Gang , Xie Aiping , Cheng Chenchen
Published: September 2024

Objective

The study investigates value of preoperative prognostic nutritional index (PNI) combined with N-terminal pro-brain natriuretic peptide (NT-proBNP) in predicting postoperative acute kidney injury (AKI) in congenital heart disease (CHD) children.

Methods

The clinical data of 108 children with congenital heart disease were retrospectively collected. According to whether AKI occurred 48 h after operation, they were divided into AKI group (n = 32) and non-AKI group (n = 76). The clinical data, preoperative PNI and NT-proBNP levels were compared between the two groups. Multivariate logistic regression analysis was used to analyze the influencing factors of AKI, and the receiver operating characteristic (ROC) curve was drawn to evaluate the predictive value of preoperative PNI, NT-proBNP and their combination.

Results

Multivariate logistic regression analysis showed that Scr, PNI and NT-proBNP were independent risk factors for postoperative AKI in children with congenital heart disease (P < 0.001). The results of ROC curve analysis showed that the area under the curve (AUC) of preoperative PNI, NT-proBNP and their combination in predicting postoperative AKI in children with congenital heart disease were 0.839, 0.738 and 0.907, respectively, and the AUC of their combination was the highest.

Conclusion

The combined use of preoperative PNI as well as NT-proBNP holds significant value in predicting postoperative AKI in CHD children. Monitoring preoperative PNI and NT-proBNP levels may aid in clinically identifying the risk of postoperative AKI in CHD children, thereby improving their prognosis.
Communicative Competence in English Among Junior High School Students
Authors: Samaranos Ann Jane , Biol Jr. Isidro
Published: September 2024

Developing communicative competence is one of the expected outcomes of the Language Arts and Multiliteracies Curriculum (LAMC). This study evaluates the communicative competence among Junior High School students at Vinapor National High School. Employing descriptive quantitative and qualitative methods, it examines the grammatical, sociolinguistic, and discourse competence and identifies factors that either facilitate or hinder these competencies. A combination of grammatical, speaking, and writing tests was used to assess student’s performance, which revealed that the majority did not meet expectations across the evaluated competencies. Semi-structured interviews further provided insights into both facilitating and hindering factors from the perspectives of 21 students and four teachers. Facilitating factors included teaching methods, peer interaction, extracurricular activities, access to resources, and teacher support, whereas hindering factors encompassed challenges and barriers such as lack of interest, lack of comprehension, lack of confidence, fear of committing mistakes, negative perception, curriculum and resource limitations, and distractions. The study proposed an intervention program to guide teachers in helping students achieved communicative competence.
O interesse de estudantes do ensino médio em cursos de engenharia ao longo da realização de práticas educativas contextualizadas
Authors: Feitosa Wesley Gomes , Dal-Farra Rossano André
Published: September 2024

As carreiras de engenharia desempenham um papel fundamental no crescimento dos países, gerando a necessidade de os estudantes desenvolverem suas escolhas a partir dos cursos de nível superior ofertados em cada região. No caso do estado de Amazonas, o polo industrial oferece relevantes oportunidades laborais para os estudantes, e a gestão educacional e laboral demanda processos formativos adequados para este contexto. Diante de tais premissas, o presente estudo compreende a análise de um conjunto de atividades desenvolvidas com estudantes do Ensino Médio do 1º. ao 3º. ano relacionadas com a profissão do engenheiro na perspectiva da Ciência, Tecnologia, Engenharia e Matemática. O processo foi acompanhado pela aplicação de questionários respondidos pelos estudantes. Os dados obtidos foram analisados com a Estatística Descritiva e Inferencial. Os resultados demonstraram que o interesse dos estudantes nos cursos foi intermediário, com escores médios próximos a 3,00, e valores moderadamente superiores para áreas tais como a Engenharia da Computação, seguida de Engenharia Civil, Engenharia Mecânica e Engenharia de Produção. A totalidade do processo realizado indicou a necessidade de realizar tais ações na escola visando proporcionar um maior conhecimento em relação aos cursos para que os estudantes que possuam inclinações profissionais desta natureza possam optar por tais carreiras na educação superior.
Avaliando a maturidade digital no ministério público brasileiro: uma ferramenta para diagnóstico da transformação digital
Authors: Freitas Luciana Maria de Araujo , Zattar Guilherme André Pacheco , Silva Júnior Paulo Célio Soares da , Pedrosa Glauco Vitor
Published: September 2024

A Transformação Digital (TD), tendência em governos ao redor do mundo, vai além da tecnologia, demandando uma mudança cultural que inclui agilidade e inovação. Para impulsionar ainda mais a TD no setor público, é crucial entender de forma clara e prévia o status atual do nível de digitalização existente, mas faltam estudos sobre maturidade digital no setor público brasileiro. Este trabalho realiza uma pesquisa com o Ministério Público brasileiro, usando adaptações de modelos de maturidade digital do setor privado, visando auxiliar a Administração Pública na criação de valor público rumo a uma TD plena e eficaz. A análise dos dados revelou áreas de progresso e outras que necessitam de melhorias, podendo contribuir para delinear estratégias que transformem os serviços públicos no Brasil, tornando-os mais eficientes, mais simples, mais humanos e mais digitais.
Application of the International Classification of Functioning, Disability and Health Model in Recurrent Guillain-Barré Syndrome: A Case Report
Authors: Naik Prashant Prabhakar
Published: September 2024

The present case report utilises the International Classification of Functioning, Disability and Health (ICF) model to assess the health condition and its impact on various health domains of a 46-year-old male who experienced recurrent Guillain-Barré Syndrome (GBS) for the second time within three years. The patient presented with sudden difficulty swallowing solid food and bilateral lower limb weakness, struggling to rise from a sitting position. The report explores the patient’s ICF profile, highlighting the effect of GBS on his daily life and recovery process. The patient’s remarkable recovery can be attributed to several factors, despite the challenges faced. These factors include good socio-economic status, motivation, family support and consistent physiotherapy. Together, these elements played pivotal roles in facilitating the recovery process.
Barriers to Successful Beekeeping: Insights from the Jammu Region of Jammu and Kashmir, India
Authors: Bhagat Goldy , Bhat Anil , Kachroo Jyoti , Sharma Rakesh , Sharma L. K. , Sharma Manish
Published: September 2024

This study focused on the constraints faced by the beekeepers of Jammu region of Jammu and Kashmir, evaluating constraints perceived by the beekeepers identified from Krishi Vigyan Kendras (KVKs) who have been involved in beekeeping for the last five years at least and the list contained eight beekeepers. By using the sampling method with replacement, the sample size of eight beekeepers were interviewed two times and comparison made for three time periods or years viz; 2019-20, 2021-22 and 2023-24, which made the ultimate sample size of twenty four (24) beekeepers. For analyzing the data collected for three time periods, Henry Garrett’s ranking and Chi-square test were used. Findings indicated that major production constraints were the disease of honey bees (78.60), death of the colony (70.00), and heavy rainfall (61.00). Marketing constraints included the fluctuating price of raw honey (69.20), unorganized and unregulated markets (63.20) and lack of government concern or support for the marketing of honey (55.80). Economic constraints featured the huge cost of investment is ranked first with an average score of 71.00, followed by no insurance facilities for the beehives with an average score of 53.67 and lack of credit supply for costly implements used in processing, packaging and quality testing (50.67). Chi-square test revealed that only two constraints under production problems such as, the lack of beehive equipments and materials in the local market (14.77) and pesticide poisoning (7.88) were significant and were showing dependency over the years. By addressing all these constraints through targeted interventions could significantly enhance the viability of beekeeping.
Maxillary Acanthomatous Ameloblastoma in Dog: Case Report
Authors: Ferreira Mateus dos Prazeres , Palma Mariza Brandão , Silva João Paulo Gomes da , Soares Anísio Francisco
Published: September 2024

This report aims to describe a case of acanthomatous ameloblastoma in the central region of the left maxilla in a dog that had a history of sialorrhea and hyporexia. A 12-year-old Shih Tzu dog weighing 5 kg was treated at a veterinary clinic specializing in veterinary dentistry. The animal had an increase in volume in the left maxilla caused by a pink mass with irregular contours. The animal had difficulty eating and was progressively losing weight. Imaging tests revealed a neoplastic growth and displacement of the teeth affected by the tumor mass, without bone involvement. In the histopathological examination the gingival cells were polygonal in shape with broad, eosinophilic cytoplasm, with distinct borders and evident desmosomal junctions, arranged in a palisade or perpendicular to the basement membrane, being compatible with acanthomatous ameloblastoma. The treatment of choice was surgical removal. In the postoperative evaluation the dog presented dehiscence of the suture and underwent reintervention to perform a new suture. In the immediate postoperative period, the animal remained active. Although adult dogs, of medium to large size, are the most affected by this type of tumor, this work demonstrates that small breeds can also develop the disease. The location of the tumor reported here also differs from that commonly reported in the literature. The full recovery of patients affected by acanthomatous ameloblastoma will depend on the ability to perform an appropriate clinical-surgical approach, seeking excision of the tumor with free margins and correct postoperative follow-up.
Assessment of Okra Powdery Mildew (Erysiphe Cichoracearum DC) by Using Bio-agents and Chemical Fungicides
Authors: Malav Satyandra , Babele J K , Meena Chandra Mohan , Malav Mohit , Sharma Chandra Prakash
Published: September 2024

The present study aimed to assess okra powdery mildew (Erysiphe Cichoracearum DC) by using bio-agents and chemical fungicides. Okra (Abelmoschus esculentus (L.) Moench occupies a prominent place in the horticultural wealth and economy of the country. Powdery mildew disease on okra (Abelmoschus esculentus (L.) Moench incited by fungus, Erysiphe cichoracearum is a limiting factor in the successful cultivation in Bundelkhand region of Uttar Pradesh. Studies were carried out to find out disease management strategies against okra powdery mildew using bioagents and chemical fungicides. Disease incidence declined after first, second and third sprays. The fungicide Hexaconazole (Contaf 5% EC) @ 0.1%, showed significantly lowest disease incidence (19.53 %) with maximum (68.40 %) disease control. On the basis of effectiveness in controlling the powdery mildew disease of okra the most effective fungicides recorded in the order of merit were Carbendazim (Bavistin 50WP) @0.1%, Propiconazole (Tilt 25EC) @0.1%, Trichoderma viride (3 %), Sulphur (Sulfex 80% WP) @ 0.3%, Pseudomonas flouresens (4 %) and Trichoderma harizum (4 %).
Analyzing Spatial-temporal Variation in Water Quality Parameters in South Coast Estuarine Ecosystem, Kenya
Authors: Nyakeya Kobingi , Onchieku James , Masese Frank , Gichana Zipporah , Getabu Albert , Nyamora Jane
Published: September 2024

Estuarine ecosystems are classified as among the most productive systems on the planet earth supporting an array of biodiversity. However, due to the ever increasing human population, they experience environmental degradation originating from intensive anthropogenic activities hence the need for regular assessment and monitoring to inform its management. The purpose of this study, therefore, was to analyze the spatio-temporal variation in water quality parameters in South Coast estuarine ecosystem, Kenya. Twelve sampling stations were identified based on different hydrological regimes, anthropogenic activities, and accessibility factors. Sampling was done for 12 months taking into account different seasons of the year. Such parameters as temperature, dissolved oxygen, pH, conductivity, salinity and TDS were collected in situ using YSI Multiparameter meter (Professional plus) whereas nutrients (nitrates, phosphates and ammonia) were analyzed in the laboratory using established methods. Two-way analysis of variance (ANOVA) was applied to discriminate any significant differences among stations and between seasons, and where there was a difference, Tukey post hoc test was applied to show which site differed from each other. Principal Component Analysis (PCA) was performed to correlate the environmental factors with sampling sites, and months. There was significant difference in water quality parameters among the sampling stations (P = .05) that was attributed mainly to anthropogenic activities, and both the point and non-point sources of pollution. Conversely, there was no significant difference in most of the water quality attributes in terms of seasons due to unpredictable weather patterns associated with climate change. There is need for long term monitoring strategies in order to generate sufficient data for sound management of South Coast estuary in Kenya. The study further recommends for community sensitization and implementation of relevant policies on the protection and management of riparian land.
Immediate and Successful Management of Avulsed Teeth: A Case Reports
Authors: N Thejashree , N Vanamala , Prasad B S Keshava
Published: September 2024

Avulsion and midroot fractures of teeth present significant challenges in dental trauma management. These case reports outlines the successful management of avulsed after a lapse of 2hrs in 1st case report and 24hrs in 2nd case report and midroot fractured tooth, focusing on immediate steps, long-term strategies, and clinical considerations. Midroot fractures often present with compromised structural integrity, necessitating stabilization and protection of the tooth to prevent further damage.  Splinting techniques stabilize the tooth and promote healing of periodontal tissues. However, careful monitoring is crucial to assess for potential complications such as inflammatory root resorption and external root resorption.  In both the cases extraoral root canal treatment was done for avulsed tooth and then reimplanted into the socket and stabilisation was done using splinting. Followup up was done at regular intervals of one and 3 months which showed no resorption or perapical changes, lack of clinical symptoms 
In conclusion, the management of avulsed and midroot fractured teeth requires long-term treatment strategies. Favorable outcomes can be achieved, preserving tooth function, and esthetics in patients with traumatic dental injuries.
Effect of NPK and Growth Regulators on Growth and Productivity of Wheat (Triticum aestivum L.)
Authors: Ramnath  , Sahu Dev Narayan , Tikariha Monika , Kumar Ravindra , Verma Nagendra Kumar
Published: September 2024

The present study highlights the effect of NPK and growth regulators on growth and productivity of wheat (Triticum aestivum L.). Wheat is one of the most important and widely grown food crops with over 25000 different cultivars. The exploration was carried out during Rabi season 2021-22 at Instructional farm, BTC College of Agriculture and Research station, Bilaspur (C.G.). The soil of the experimental site was clayed in texture. The wheat (Var. HI-1544) was grown and treatments were replicated three times in randomized block design. The experiment consists of twelve treatments The crop was sown on 11 November, 2021 and harvesting was done on 24 March 2021.The result that higher grain (45.55 q ha-1) and straw (46.45 q ha-1) yield were observed under the treatment 150% RDF + Two spray of growth regulator at first node(35 DAS) & boot leaf stage (60 DAS) (T9). The improvement in yield of wheat was recorded with the application of 150% RDF + Two spray of growth regulator at first node(35 DAS) & boot leaf stage (60 DAS) (T9) which was at par with the application of 150% RDF (T6). Treatment (T9) assigned yield advantage of 21.19% and 21.52% in grain and straw yield respectively as compared to 150% RDF (T6) and Absolute control (T1). The result of the present study came to the conclusion that the application of 150% RDF+ growth regulators through fertilizer is essential to get higher production output and profit from wheat cultivation and reduce the risk.
Exploring Influences on Children’s Behavior toward Dental Prophylaxis
Authors: Ribeiro Maria Eugênia Domingueti Rabelo , Orlandi Lara Evangelista , Almeida Nayara , Domingues César Augusto Moreira , Rodrigues Rodrigo , Araújo Leandro Fernandes , Oliveira Daniela Silva Barroso de , Lima Daniela Coelho de , Gomes Heloisa de Sousa
Published: September 2024

Aims: Children’s behavior can vary according to several factors associated with individual characteristics and external factors such as social and family issues. This study aimed to analyze and compare the behavior of children undergoing dental prophylaxis using a low-rotation handpiece versus a toothbrush, while also examining the relationship with their oral health status, as well as demographic and socioeconomic factors.
Study Design:  This was a cross-sectional study.
Place and Duration of Study: The study included children aged between 4 and 12 years who were seen at the Pediatric Dentistry clinic of the Faculty of Dentistry at the Federal University of Alfenas (UNIFAL-MG) from March to July, 2023.
Methodology: These questions were evaluated using Frankl’s Behavior Rating Scale, to assess children’s behavior, the DMFT/dmft index to assess the oral condition, and a questionnaire to assess socioeconomic and demographic conditions. The data was analyzed using IBM SPSS software version 22.0 (P<0.05), using the Kruskal-Wallis and Chi-Square tests.
Results: A total of 153 children were included, 52.3% (n=80) of whom underwent prophylaxis using toothbrush. The mean age of the children was 7.62 (±2.32) years, of which 53.6% (n=82) were male. In this analysis, an association was observed between definitely negative behavior with children of single parents (P=.01), with higher severity of caries disease (P=.02), with a greater number of decayed teeth (2.39 (±3.26), P=.005), with a high DMFT index (5.13 (±3.50), P=.04) and with children who had primary teeth (P=.01).
Conclusion: The method of dental prophylaxis did not significantly impact the children’s behavior in this sample. However, children who exhibited uncooperative behavior had more decayed teeth and worse oral condition severity. Knowing this, it is possible to choose some methods more accurately so that the child feels more welcome at the first visit, such as the use of management techniques like the tell-show-do technique, the modeling technique and also the use of distractions, such as videos, books and other media.
Assessment of the Knowledge, Attitude and Practice (KAP) of PMTCT among Healthcare Providers at the University of Ghana Legon
Authors: Kor Elijah , Kor Jacob Aaworb-nang Maabobr
Published: September 2024

One of the leading causes of morbidity and mortality among communicable diseases is acquired immunodeficiency syndrome (AIDS). A vulnerable group in this setting is HIV exposed infants, (born to women living with HIV). The magnitude of the pandemic of HIV infection in developing countries is such that multiple approaches are required to show its spread and alleviate the burden on the health sector and society in general. Every woman of childbearing age needs to be aware of HIV infection, the risks of Mother-to-Child Transmission and the services available to reduce such risks. Considering these, this study assessed the knowledge, attitude and practice of Prevention of mother-to-child transmission (PMTCT) among healthcare providers at the University of Ghana Legon. A descriptive cross-sectional design was used in this study. The minimum sample size for this study was calculated using the single proportion population formula by Fisher (1978):
The study area was the University of Ghana Hospital Legon. The collected data was exported into STATA version 16.0 for cleaning and analysis. Descriptive analysis, such as simple frequencies, percentages, means, and standard deviations, were used to summarize the data. Findings were presented in tables and graphs. Generally, the data accumulated from the research on the knowledge, attitude and practice of PMTCT among healthcare workers indicate that there is unsatisfactory knowledge and practice. In this study, no participants had a total good score above 85%. The relationship between gender, ward and knowledge was investigated using a chi-square. The p-value was higher than the alpha-value, indicating acceptance of the null hypothesis (p-value = 0.79 and 0.053, alpha value = 0.05). Sixteen (16) of the respondents, representing 17.6%, said HIV positive pregnant women should be managed like any other pregnant woman in Labour. The majority of the respondents (56) said at the first week of pregnancy, while only (2) said at week 28. However, their attitude was satisfactory. It must be noted that without further training and an increase in staffing levels, the quality and accessibility of PMTCT will be severely affected. It is therefore recommended that there should be continuous and pre-service training on PMTCT. All new medical officers, midwives and nurses should undergo PMTCT training, and those who are already in service should take refresher courses on new and updated guidelines.
Steuerliche Gewinnermittlung – internationale Rechnungslegung auf dem Vormarsch?!
Authors: Benzel Ute
Published: September 2024

Mein Impulsvortrag zu dem Thema „Steuerliche Gewinnermittlung - internationale Rechnungslegung auf dem Vormarsch?!“ umfasst 3 Thesen: These 1: Die Internationale Rechnungslegung ist auf dem Vormarsch für die steuerliche Gewinnermittlung! These 2: Eine Komplexitätsreduktion ist erforderlich! These 3: Die Zukunft der steuerlichen Gewinnermittlung sollte aktiv gestaltet werden.
Tagungs- und Diskussionsbericht zum 91. Berliner Steuergespräch am 10.6.2024 „Steuerliche Gewinnermittlung – internationale Rechnungslegung auf dem Vormarsch?!“
Authors: Richter Andreas , Welling Berthold
Published: September 2024

Harmonisierungsbemühungen auf EU-Ebene führen zu einer stetig wachsenden Bedeutung der Internationalen Rechnungslegungsstandards auch für die nationale Rechnungslegung. So müssen Konzernabschlüsse kapitalmarktorientierter Unternehmen seit 2005 nach den International Financial Reporting Standards (IFRS) erstellt werden und haben zudem durch das Bil- MoG Einzug in den handelsrechtlichen Jahresabschluss gehalten. Im Steuerrecht wurde erstmals im Rahmen der Zinsschranke auf IFRS verwiesen. Auch die Bemühungen der EU-Kommission zur Einführung einer einheitlichen Bemessungsgrundlage zur Körperschaftsteuer sowie die OECD-Mindeststeuer baut auf den internationalen Rechnungslegungsstandards auf. Im nationalen Steuerrecht hingegen gilt nach wie vor die HGBMaßgeblichkeit. Jedoch sind HGB-Abschluss und Steuerbilanz durch zahlreiche Abweichungen und nicht zuletzt durch die Aufgabe der umgekehrten Maßgeblichkeit im Zuge der letzten großen Bilanzrechtsreform auseinandergedriftet. Im Ergebnis stehen die internationale Rechnungslegung und HGB immer mehr im Spannungsverhältnis zur Steuerbilanz. Das 91. Berliner Steuergespräch bot den Referenten WP/StB Ute Benzel, Prof. Dr. Dirk Hachmeister, Universität Hohenheim, und den Podiumsdiskutaten Kirsten Birnbaum, SAP SE, Prof. Dr. Sven Morich, DSRC, und Dr. Anett Albrecht, BMF, die Gelegenheit, die Bedeutung internationaler Rechnungslegungsstandards aufzugreifen und über die Zukunft der steuerlichen Gewinnermittlung in Deutschland zu diskutieren.