bluuebunny/crossref_metadata_2025 huggingface dataset:
On the Application of the Channel-Fracturing Technique to Soft Rock Formations
Authors: Khanna Aditya , Kotousov Andrei , Luong Hao Thanh
Published: December 2018

The application of the channel-fracturing technique can result in a significant increase in the conductivity of hydraulic fractures and reduced proppant usage. In soft rock formations, the conductivity of the partially propped fractures would depend not only on the volume fraction of the open channels, but also on the elastic deformation of open channels and fracture closure resulting from proppant consolidation and embedment. In this study, an analytical approach is developed for identifying the optimal proppant column spacing that maximizes the effective conductivity. The latter parameter can guide the design of the proppant-injection schedule and well-perforation scheme. To demonstrate the approach, we conduct a parametric study under realistic field conditions and identify the folds of increase in fracture conductivity and reduction in proppant use resulting from the optimized application of the channel-fracturing technique. The outcomes of the parametric study could be particularly useful in the application of the developed approach to soft rock formations.
A spatial application of the water poverty index (WPI) in the State of Chihuahua, Mexico
Authors: Wurtz Marie , Angeliaume Alexandra , Herrera María Teresa Alarcón , Blot Frédérique , Paegelow Martin , Reyes Víctor Manuel
Published: December 2018

The Water Poverty Index (WPI) standardizes water scarcity diagnostics by considering natural, environmental, and socioeconomic factors which reduce, facilitate, or prevent water access. To integrate these factors, the WPI includes five components: resource, environment (negatively affected by development), capacity, access, and use (positively affected by development). Nevertheless, the place granted to hydrological factors is questioned, and many studies insist on the problematic correlation of WPI with the well-known Human Development Index (HDI). Calculating WPI in the socially heterogeneous and semi-arid context of the State of Chihuahua (Mexico), adapting traditional methodology thanks to geographic information systems (GIS) tools and the corresponding databases, allows discussion of those points. This study uses multi-criteria evaluations from TerrSet software to calculate WPI while preserving specific data precision. In this process, scale calculation and indicator normalization are adapted through raster maps and fuzzy techniques to valorize specific hydrological data. This opens interesting discussions for multidimensional water scarcity diagnostics, since they increase the visibility of diverse water scarcity issues in WPI results. In fact, concentrating socioeconomic factors in corresponding components and valuing GIS alternatives provides a diagnostic different from the HDI and sensitive to hydrological factors.
Structural Basis for Inhibition of Enoyl-[Acyl Carrier Protein] Reductase (InhA) from Mycobacterium tuberculosis
Authors: de Ávila Maurício Boff , Bitencourt-Ferreira Gabriela , de Azevedo Walter Filgueira
Published: December 2018

Background::

The enzyme trans-enoyl-[acyl carrier protein] reductase (InhA) is a central
protein for the development of antitubercular drugs. This enzyme is the target for the pro-drug
isoniazid, which is catalyzed by the enzyme catalase-peroxidase (KatG) to become active.

Objective::

Our goal here is to review the studies on InhA, starting with general aspects and focusing on
the recent structural studies, with emphasis on the crystallographic structures of complexes involving
InhA and inhibitors.

Method::

We start with a literature review, and then we describe recent studies on InhA crystallographic
structures. We use this structural information to depict protein-ligand interactions. We also analyze the
structural basis for inhibition of InhA. Furthermore, we describe the application of computational
methods to predict binding affinity based on the crystallographic position of the ligands.

Results::

Analysis of the structures in complex with inhibitors revealed the critical residues responsible
for the specificity against InhA. Most of the intermolecular interactions involve the hydrophobic residues
with two exceptions, the residues Ser 94 and Tyr 158. Examination of the interactions has shown
that many of the key residues for inhibitor binding were found in mutations of the InhA gene in the
isoniazid-resistant Mycobacterium tuberculosis. Computational prediction of the binding affinity for
InhA has indicated a moderate uphill relationship with experimental values.

Conclusion::

Analysis of the structures involving InhA inhibitors shows that small modifications on
these molecules could modulate their inhibition, which may be used to design novel antitubercular
drugs specific for multidrug-resistant strains.
THE	DETERMINATION OF THE SURFACE ADHESION RESISTANCE AND PENDULUM	HARDNESS ON THE PARQUETS APPLIED UV VARNISH	AS SINGLE AND DOUBLE LAYERS
Authors: AYATA Ümit , ÇAVUŞ Vedat
Published: December 2018

In this study, it aimed to determine the pendulum hardness and adhesion resistance  test results on the parquets which are produced from sapeli, limba, chestnut and  iroko applied ultraviolet (UV) varnish sistem according to different varnish layers.  As a result of this; the pendulum hardness and surface adhesion values were  determined on the materials derived from the different layers. Consequently, it was  found that the double layer UV system varnish had a higher pendulum hardness  value than the single layer application. As a matter of fact, as the number of UV system varnish layer increased, the pendulum hardness values increased in the  same ratio. Taking into account the results of the surface adhesion resistance  experiments, it can be said that the wood texture has an important role on the UV  system varnish application.
ATIK BİTKİSEL YEMEKLİK YAĞLARIN SAF BİTÜM ÖZELLİKLERİNE ETKİSİNİN ARAŞTIRILMASI
Authors: GÖKALP İslam , ÖZİNAL Yağmur , UZ Volkan Emre
Published: December 2018

Bitkisel
yemeklik yağlar, insanların temel besin öğesinden birisini oluşturmaktadır.
Sadece Türkiye’de değil, tüm dünyada insan nüfusu her geçen gün artmakta ve bu
daha fazla temel besin malzemesine gereksinim duyan insan topluluğu
doğurmaktadır. İnsanların kullandıkları yağ miktarındaki artış, beraberinde
doğal olarak tehlikeli atık sınıfında yer alan atık bitkisel yemeklik yağlar
(ABYY) sorununu ortaya çıkarmaktadır. Yönetmenliklerin öngördüğü yöntemlerle
toplanmalarının, taşınmaların ve bertaraf edilmelerinin sağlanamaması durumda,
ilgili belde ve yönetimleri için ciddi çevresel problemlere neden
olabilmektedir. Bu çalışmada, ABYY’lerin bertaraf etme yöntemlerine alternatif
bir yaklaşımda bulunulmuş ve bitümde bir katkı maddesi olarak kullanılabilirliği
ve bitüm özeliklerine olan etkisi araştırılmıştır. Bu kapsamda, 70/100
penetrasyon sınıfına sahip bitüm ve ABYY temin edilmiştir. % 2, 4, 6, 8 ve 10
(Bitüm ağırlığınca) oranında ABYY bitüme eklenmiş, homojen bir karışım elde
edilmesi için standart bir metotla karıştırılmıştır. ABYY katkılı bitüm ve taze
bitüm numunelerine, penetrasyon, yumuşama noktası, parlama noktası, düktilite
ve iki farklı sıcaklıkta dönel Viskozimetre testleri uygulanmıştır. Sonuç
olarak, ABYY’lerin bitüm özeliklerini belirgin bir şekilde değiştirdiği
görülmüştür.
Interpreting HIV Diagnostic Histories into Infection Time Estimates: Analytical Framework and Online Tool (Preprint)
Authors: Grebe Eduard , Facente Shelley N. , Bingham Jeremy , Pilcher Christopher D. , Powrie Andrew , Gerber Jarryd , Priede Gareth , Chibawara Trust , Busch Michael P. , Murphy Gary , Kassanjee Reshma , Welte Alex
Published: December 2018

BACKGROUND

It is frequently of epidemiological and/or clinical interest to estimate the date of HIV infection or time-since-infection of individuals. Yet, for over 15 years, the only widely-referenced infection dating algorithm that utilises diagnostic testing data to estimate time-since-infection has been the ‘Fiebig staging’ system. This defines a number of stages of early HIV infection through various standard combinations of contemporaneous discordant diagnostic results, using tests of different sensitivity.

OBJECTIVE

To develop a new, more nuanced infection dating algorithm, we generalised the Fiebig approach to accommodate positive and negative diagnostic results generated on the same or different dates, and arbitrary current or future tests – as long as the test sensitivity is known. For this purpose, test sensitivity is conceptualised as the probability that a specimen will produce a positive result, expressed as a function of time since infection. This can be summarised as a median ‘diagnostic delay’ parameter, together with a measure of inter-subject variability.

METHODS

The present work outlines the analytical framework for infection date estimation using subject-level diagnostic testing histories, and data on test sensitivity. We introduce a publicly-available online HIV infection dating tool that implements this estimation method, bringing together 1) curatorship of HIV test performance data, and 2) infection date estimation functionality, to calculate plausible intervals within which infection likely became detectable for each individual. The midpoints of these intervals are interpreted as infection time ‘point estimates’ and referred to as Estimated Dates of Detectable Infection (EDDIs).

RESULTS

In many settings, including most research studies, detailed diagnostic testing data are routinely recorded, and can provide reasonably precise estimates of the timing of HIV infection. We present a simple logic to the interpretation of ‘diagnostic testing histories’ into ‘infection time estimates’, either as a point estimate (EDDI) or an interval (earliest plausible to latest plausible dates of detectable infection), along with a publicly-accessible online tool that supports wide application of this logic.

CONCLUSIONS

This tool, available at https://tools.incidence-estimation.org/idt/, is readily updatable as test technology evolves, given the simple architecture of the system and its nature as an open source project.
The Deep Learning–Based Recommender System “Pubmender” for Choosing a Biomedical Publication Venue: Development and Validation Study (Preprint)
Authors: Feng Xiaoyue , Zhang Hao , Ren Yijie , Shang Penghui , Zhu Yi , Liang Yanchun , Guan Renchu , Xu Dong
Published: December 2018

BACKGROUND

It is of great importance for researchers to publish research results in high-quality journals. However, it is often challenging to choose the most suitable publication venue, given the exponential growth of journals and conferences. Although recommender systems have achieved success in promoting movies, music, and products, very few studies have explored recommendation of publication venues, especially for biomedical research. No recommender system exists that can specifically recommend journals in PubMed, the largest collection of biomedical literature.

OBJECTIVE

We aimed to propose a publication recommender system, named Pubmender, to suggest suitable PubMed journals based on a paper’s abstract.

METHODS

In Pubmender, pretrained word2vec was first used to construct the start-up feature space. Subsequently, a deep convolutional neural network was constructed to achieve a high-level representation of abstracts, and a fully connected softmax model was adopted to recommend the best journals.

RESULTS

We collected 880,165 papers from 1130 journals in PubMed Central and extracted abstracts from these papers as an empirical dataset. We compared different recommendation models such as Cavnar-Trenkle on the Microsoft Academic Search (MAS) engine, a collaborative filtering–based recommender system for the digital library of the Association for Computing Machinery (ACM) and CiteSeer. We found the accuracy of our system for the top 10 recommendations to be 87.0%, 22.9%, and 196.0% higher than that of MAS, ACM, and CiteSeer, respectively. In addition, we compared our system with Journal Finder and Journal Suggester, which are tools of Elsevier and Springer, respectively, that help authors find suitable journals in their series. The results revealed that the accuracy of our system was 329% higher than that of Journal Finder and 406% higher than that of Journal Suggester for the top 10 recommendations. Our web service is freely available at https://www.keaml.cn:8081/.

CONCLUSIONS

Our deep learning–based recommender system can suggest an appropriate journal list to help biomedical scientists and clinicians choose suitable venues for their papers.
MOLECULAR DOCKING STUDIES ON THIADIAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS
Authors: Sivakumar D. , Geetha G.
Published: December 2018

Objective: In the present study, a novel series of 1, 3, 4-thiadiazole derivatives were docked against the mycobacterium tuberculosis protein kinase G. 1, 3, 4–thiadiazole derivatives with a modified primary amine group at 5th position were used for docking studies.Methods: The three-dimensional structure of the protein was obtained from PDB, and its active sites were predicted. The structures of all the compounds were drawn using chemdraw software version 8.0. The docking studies were done by using schrödinger software against the enzyme protein kinase G. Totally eighteen compounds was synthesized based on glide scoreResults: In this Docking study the thiadiazole analogues were showing good binding energy. The amino acids residues GLU588, SER412, GLY410 and GLU 628 in the kinase domain active site form hydrogen bonds with the ligand.Conclusion: The compounds D34, D16, D7, D25, D15, and D27 showed better interaction with protein kinase G (pknG) more than the other drug molecules
HEALTH-RELATED QUALITY OF LIFE IN EARLY BREAST CANCER PATIENTS WITH HORMONE RESPONSIVE
Authors: Rukminingsih Fef , Andayani Tri Murti , Rahmawati Fita , Widayati Kartika
Published: December 2018

Objective: The management of early breast cancer (EBC) is performed with a series of treatments consisting of surgery and systemic therapy, along with long-term endocrine therapy for hormone responsive. The treatment generates a high illness effect that will affect the life quality of EBC patients. The objective of this study was to measure EBC patients’ quality of life after undergoing the treatment.Methods: A cross-sectional study was conducted by interviewing EBC patients using EQ-5D-5L instrument at private hospitals in Yogyakarta and Semarang, Indonesia. The EBC patients were women aged 18-60 y who had undergone surgery in 2010-2013 and received endocrine therapy.Results: Of the 71 patients identified, 45 patients were in disease-free survival (DFS) state, 8 patients were in locoregional recurrence (LR), and 18 patients were in metastasis (M) state. Mobility and self-care problems occurred in patients who had metastasis (4.23%). The problem of usual activities occured in patients who had recurrence (22.54%). Most of the patients (84.51%) had pain problem, and all patients had an anxiety problem. The mean utility score (SD) in DFS patients was 0.841 (0.052), in LR patients was 0.758 (0.092), and in patients who had metastasis was 0.653 (0.104). The mean scores of EQ-5D VAS (SD) for EBC patients in DFS, LR and M health state were 86.56 (6.29), 81.88 (5.30), and 69.17 (5.75), respectively.Conclusion: The health states of EBC significantly affect HRQOL of patients. Efforts should be made to improve the quality of life of EBC patients especially in terms of pain and anxiety reduction.
PARADIGMA METODOLOGI DAKWAH DAN PERUBAHAN SOSIAL PADA MAJELIS TAKLIM
Authors: Khadijah Khadijah
Published: December 2018

Penelitian ini menunjukkan bahwa semakin termetodologikan kegiatan dakwah maka dalam perubahan sosialnya akan semakin membentuk umat yang berperadaban (masyarakat madani/civil society). Penemuan penelitian lainnya mengukuhkan, bahwa metodologi ilmu komunikasi dapat diterapkan untuk membangun metodologi ilmu dakwah. Jenjang keilmuan ilmu komunikasi sejajar dengan jenjang keilmuan dakwah. Penulis memformulasikan metodologi ilmu dakwah dalam empat hal, yaitu tablig (information); tagyīr (change); al-binā (development); dan al-mujtama’ al-madani (civil society). Penelitian ini memperkuat pendapat Hamid Mowlana (2002) dan Andi Faisal Bakti (2010) yang menyatakan bahwa sesuai dengan perubahan sosial, dakwah seharusnya melibatkan secara aktif seluruh komponen-komponennya sehingga mampu membentuk suatu masyarakat yang berperadaban. Penelitian ini sekaligus juga menyanggah pendapat Max Weber (1946) yang menyatakan ajaran Islam mempunyai sikap anti akal dan sangat menentang ilmu pengetahuan, sehingga tidak mungkin menjadi agen perubahan sosial. Dalam perubahan sosial, peranan dakwah selain berfungsi sebagai penyampai informasi juga sebagai sarana mendidik, mengkritik, pengawasan sosial, menjaga lingkungan, pengembangan keilmuwan, membangun kesejahteraan umat, memberdayakan masyarakat untuk hidup lebih produktif dan berperadaban. Dakwah bukan hanya sekedar disampaikan tapi harus diterapkan secara tepat pada tempat, waktu dan sasaran. Sumber utama dari penelitian ini didapatkan melalui studi kepustakaan (library research) dengan mengacu kepada literatur-literatur dakwah. Data-data dakwah kontemporer yang diperoleh dari literatur ditunjang dengan data studi turasts Islam. Sebagai studi lapangan penelitian ini meneliti perubahan sosial pada objek penyelenggaraan Majelis Taklim. Semua buku dan sumber lainnya dikumpul untuk dianalisa dengan pendekatan kerangka ilmu sosial untuk memformulasikan hadirnya konsep perubahan sosial paradigma baru Majlis Taklim dan penerapannya.
¿Penas sin humillaciones? Límites al derecho penal derivados del respeto a la dignidad humana
Authors: Tamayo Arboleda Fernando León , Sotomayor Acosta Juan Oberto
Published: December 2018

El presente texto se propone analizar los límites a la intervención penal derivados del contenido constitucional de la dignidad humana, entendida como intangibilidad de integridad física y moral del individuo, no sin antes precisar, de forma muy breve, la función del principio de respeto a la dignidad humana en el derecho penal, en general, y la manera como las diferentes atribuciones que caracterizan este principio según su elaboración por parte de la Corte Constitucional se configuran como límites al poder penal del Estado. Para ello, se realiza un análisis de la jurisprudencia de la Corte Constitucional usando herramientas de la dogmática constitucional y penal. El artículo propone que, a pesar de la diáspora jurisprudencial y la complejidad del concepto dignidad humana, es posible derivar un contenido del mismo que sirva como limitación del derecho penal en el marco del Estado de derecho.
La argumentación a favor del trabajo sexual y sus implicaciones éticas
Authors: Gimeno Presa Mª Concepción
Published: December 2018

Cómo deben actuar los Estados democráticos modernos ante la práctica de la prostitución constituye actualmente una cuestión polémica. Dentro del movimiento feminista la forma de resolver este problema ha generado una brecha que parece difícil de resolver. Las partidarias de que los gobiernos regularicen la prostitución como una relación laboral más justifican su postura con argumentos que consideran sólidos jurídicamente y neutrales desde el punto de vista ético. Afirman que las razones dadas para prohibir la prostitución y para no considerarla una actividad laboral son razones morales. A su vez, sostienen que los Estados democráticos de derecho no tienen como función el imponer creencias éticas a sus ciudadanos sino salvaguardar los derechos de los mismos, en especial el derecho a la libertad individual. En el trabajo recojo los argumentos esgrimidos a favor y en contra de que la prostitución deba regularizarse como un trabajo y muestro cómo el razonamiento de las representantes del feminismo a favor del trabajo sexual está construido sobre una teoría ética que se presupone como válida y que, por lo tanto, no es objeto de discusión. Sostengo que la forma más adecuada de llegar a un consenso sobre este tema sería plantear abiertamente y de forma previa al debate político y jurídico, una reflexión ética sobre qué postulados y que concepción moral de la sexualidad nos parecen más valiosos para tratar este complejo problema.
La intervención de víctimas en el proceso penal y su influencia en el proceso de duelo: diálogo entre derecho y psicoanálisis
Authors: Silva Segalla Giovanna , Slavin Pablo , Filomena Cremasco María Virginia
Published: December 2018

El presente artículo se propone reflexionar, a partir de aportes del psicoanálisis, sobre ciertos efectos del creciente papel otorgado a la víctima en el proceso penal, reconocido por varios autores como una tendencia de las reformas legislativas procesales latinoamericanas. Sin perjuicio de reconocer la existencia de otros aspectos problemáticos, el objeto será reflexionar sobre la situación de los familiares de quienes sufrieran una muerte violenta, que deciden asumir el rol de acusadores privados en el proceso penal y las consecuencias que esa intervención puede tener en su proceso de duelo. Desde la concepción de que el conocimiento jurídico resulta limitado para entender los efectos de las soluciones legales, en tanto el derecho actúa en la vida social e individual de sus destinatarios, se acudirá a la contribución que al respecto puede brindar el psicoanálisis. Con esos insumos, se propondrán ciertos lineamientos que se estiman útiles para el diseño de una normativa e institucionalidad de acompañamiento a la víctima, que reduzca los posibles efectos nocivos que su acogimiento en el proceso penal puede tener en su proceso de duelo.
VARIEDADES Y VARIACIONES DE CAPITALISMO EN LA PERIFERIA. AMÉRICA LATINA Y EL ESTE ASIÁTICO RECONSIDERADOS
Authors: Ramiro Fernández Víctor , Bazza Alcides , Seiler Cristhian
Published: December 2018

El artículo propone un marco analítico alternativo al enfoque institucional de variedades de capitalismo para comprender la divergente emergencia y dinamismo industrial entre el Este Asiático y América Latina en el denominado Sur Global. El carácter alternativo se fundamenta en el distanciamiento del tratamiento nacionalista metodológico y focalizado en las complementariedades institucionales identificadas en países desarrollados –propio de este enfoque–, para considerar las características que identifican a países en contextos periféricos, y los cambios temporales y espaciales en estos. Se introduce las nociones de “núcleo de acumulación” y “núcleo de implicación estatal” como herramientas teóricas alternativas que consideran tal condición periférica –y sus cambios–, entendiendo los procesos de acumulación y los Estados que conforman las macro-regiones analizadas en una relación dialéctica e ínter-penetrante con permisividades externas y viabilidades internas.
JUSTIFICACIÓN TOPOLÓGICA DEL ÍNDICE DE HERFINDAHL-HIRSCHMAN COMO ÍNDICE GENERADO POR NORMAS
Authors: Ruiz Paredes Carlos Fabián , Ruiz Paredes Luis Eduardo , Morales Paredes Jorge
Published: December 2018

Este trabajo propone una manera alterna de justificar el índice de Herfindahl-Hirschman; lo anterior partiendo de índices generados por normas sobre espacios vectoriales de dimensión finita. A partir de normas sobre n, se pueden construir propuestas para medir
concentración industrial. Se probará que el índice de Herfindahl-Hirschman y el índice ratio de concentración (RC1) son el límite de los índices generados por la norma euclidiana y la norma del máximo, respectivamente, esto cuando se considera un escenario hipotético de infinitos actores en la industria.
Green Synthesis Nanopartikel Perak (Agnps) Terkonjugasi Etil Parametoksi Sinamat (Epms) sebagai Bahan Tabir Surya
Authors: Agustina Agustina , Munawarah Munawarah , Lumi Stefanus Agustinus , Nur Syamsu
Published: December 2018

Green Synthesis is a method to make silver nanoparticles (AgNPs) by utilizing natural materials as bioreductors. One of the natural materials that can reduce metal ions is Kaempferia galanga rhizome because it has a chemical component that can penetrate the metal. The compounds are ethyl paramethoxycinnamate (EPMC) which is used as sunscreen. This study aims to produce AgNPs conjugated with EPMC that can be used as raw material sunscreen. This study was conducted by extracting EPMS from the Kaempferia galanga rhizome and synthesizing the AgNPs conjugated with EPMC. The synthesis results were characterized by UV-Vis Spectrophotometry, FTIR, SEM, PSA and sunscreen activity. Extracted result was obtained crystalline is ethyl paramethoxycinnamate compound with yield 2,3%. The characterization of EPMC with UV-Vis spectrophotometer was obtained maximum wavelength of 308 nm and FTIR analysis result at wave number 1701,27 cm-1 indicated the presence of carbonyl group (C = O) and 1165,97 cm-1 presence of C-O and showed specific characteristic from EPMS. Characterization of AgNPs using Uv-Vis spectrophotometer was obtained maximum wavelength of 469 nm. Characterization of AgNPs using SEM are spherical and monodispers forms.  Then, particle size using PSA obtained an average diameter of 182 nm. AgNPs conjugated with EPMS has a sunscreen activity with sunblock category and successfully provide protection against UV exposure at low concentration (200 ppm) categorized as ultra protection with SPF value 36,4.
The Incidence and Risk Factor Analysis of Drug Induced Liver Injury (Dili) in a Surabaya Hospital
Authors: Arrang Sherly Tandi , Widyati Widyati
Published: December 2018

The research has been conducted on the incident and analysis of risk factors drug liver injury (DILI) in a Surabaya Hospital. The aim of this study was to determine the incident of DILI, know which drugs cause DILI, and see the association of risk factors to DILI. The research method was descriptive and analytical observational (prospective cohort). Danan-Benichou scale is a tool used to ascertain drugs that cause DILI. Based on data collected for 3 months, the population was 1202 patients. Samples fulfilling the inclusion and exclusion criteria were 310 patients, the risk drug group of DILI were 285 patients (11 DILI, 274 Non-DILI), and the non-risk drug group 25 patients (11 DILI, 14 Non-DILI). The incident of DILI was 3.55%. Drugs that cause DILI are ranitidine (4 cases), omeprazole (1 case), rifampicin (2 cases), meropenem (1 case), ciprofloxacin (1 case), methotrexate (1 case), and dexamethasone (1 case). Characteristic of patients with DILI (11 patients) are average age of 59.27 ± 15.54 years (23-73 years), belonging to high risk group (54.55%), male gender (81,82%), have moderate comorbid disease (54.55%), and are not comsumsing alcohol (100%). This research use logistic regression analysis through SPSS 17.0 program to see the relation of risk factor to DILI incident. The p results were obtained from sex (0,156), age (0,534), and comorbid isease (0,213)> α (0,05) which means gender, age, and comorbid disease do not significantly affect the incident of DILI.
Efek Sinergitas Ekstrak Kulit Jeruk (Citrus sinensis L) Pada Patch Bioselulosa Dalam Meningkatkan Penyembuhan Luka Bakar
Authors: Roska Tri Puspita , Sahati Syahidah , Fitrah Andi Dinul , Juniarti Nana , Djide Natsir
Published: December 2018

Burns is one of the incidents that can lead to death (mortality). One of the natural products that have  potential to serve as an alternative treatment of burns is orange peel. Orange peel has a chemical composition such as ascorbic acid, vitamin E, vitamin A, and polyphenols as antioxidants that inhibit free radicals responsible in the pathogenesis of both acute and chronic inflammatory. In this study, formulation was made in the form of biocellulose which is the primary metabolism product of bacteria.  The purpose of this research was to obtain the concentration of the extract of orange peel on bioselullose that have the effect of decreasing the burn wound in rats. Orange peel was extracted then fortified into biocellulose with a concentration of 3%, 6%, and 9%. After that, the wound healing was tested on animals in the form of decreasing the wound diameter.  The results showed that the concentration of extract of orange peel 3% on the fortification of biocellulose showed the good percentage of burn wound decreasing i.e. 45.52% with diameter average of 18.35 mm. This result indicates the concentration of extract of orange peel 3% is better than others.
Aktivitas Ekstrak Etanol Kulit Batang Kayu Jawa (Lannea coromandelica) terhadap Penyembuhan Luka Sayat pada Tikus Putih (Rattus Norvegicus L.)
Authors: Calsum Umi , Khumaidi Akhmad , Khaerati Khildah
Published: December 2018

Jawa bark (Lannea coromandelica) is a part of the plant that can be used empirically for handling wounds. This study aims to determine the activity of ethanol extract of Jawa bark on healing wound and determine the effective dose compared with povidone iodine. The test animals used were white rats (Rattus norvegicus L.) consisting of 5 groups, namely negative control (vaseline without extract), positive control (povidone iodine), dose of 250 mg/kg BW, dose of 500 mg/kg BW, dose of 750 mg/kg BW. Each rat made an incision in the area parallel to the spine with 2 cm long and 2 mm deep. Measuring the length of the wound was done every day for 14 days. The data obtained were analyzed statistically using One Way Anova and followed by Post Hoc Duncan test. Statistical results showed that the ethanol extract of Jawa bark has an activity in curing slice where the effective dose is a dose of 500 mg/kg BW with a wound healing time of 12 days.
Giardiasis in Children as a Cause of the Formation of Functional Disorders
Authors: Petrenko О. V.
Published: December 2018

The purpose was to study the structure and frequency of organic and functional pathology, as well as the characteristic features of the lifestyle in children with giardiasis. Under supervision were 132 children aged 3—18 years with giardiasis. Of these, 68 had an acute course of lambliosis, and 64 had a chronic course. The diagnosis was confirmed by coprological and serological methods. The comparison group was consisted of 113 children without giardiasis of the same age and sex. It was made the collection of complaints, anamnesis, the study of medical documentation. Results. Distinctive features of the lifestyle of children with giardiasis were: adverse sanitary and hygienic living conditions, the habit of nibbling nails, drinking unboiled water. Analysis of the frequency of organic and functional pathology showed that in children of the main group, disorders of the autonomic nervous system, diseases of the digestive organs, pathology of the respiratory system, skin and subcutaneous tissue disorders were more often recorded. 47.7% of children belonged to the category of «frequently ill children», the majority was in patients with chronic lambliosis. In the invasive group, the third group of health prevailed, which was significantly more often detected in patients with chronic parasitosis. Conclusions: the obtained data indicate the need for comprehensive rehabilitation measures and correction of sanitary and hygienic living conditions in children with giardiasis invasion.
Coastal Inundation Adaptive Strategy in Semarang Coastal Area
Authors: Suhelmi Ifan Ridlo , Triwibowo Hariyanto
Published: December 2018

Semarang Coastal has a high level of vulnerability to inundation, river flooding and tidal flooding. To solve the problems, a region has an adaptive capacity to the phenomena encountered. The aims of study to map the level of vulnerability and adaptive capacity of the region in facing the phenomenon and provide an alternative strategy in facing the impact of inundation in coastal areas. Based on capacity index and vulnerability index in 2015, most urban villages are located in quadrant 3 (58 villages), in quadrant 1 (36 villages) and quadrant 4 (5 villages). the results showed that most of villages located at coastal areas had a high vulnerability with low adaptive capacity. Considering spatial planning (RTRW) for 2030, population density changes, Semarang City Facility health facilities Plan in 2030, and the open areas as defined in the Semarang 2011-2030 spatial plan (RTRW) a major shift towards the quadrant 2 was observed, suggesting an increased capacity to encountered inundation susceptibility.
Sustainability of the Sawah Surjan Agricultural Systems in Depok Village, Panjatan Subdistrict, Kulonprogo Regency, Yogyakarta Special Province
Authors: Rijanta R
Published: December 2018

The south coastal region of Yogyakarta Province (YSP) in Indonesia has inherited a unique farming system called sawah surjan, which is considered as a cultural heritage that demonstrates a form of local wisdom in managing land resources with poor drainage. The local residents have succeeded in realizing their desire of making the farming system ecologically stable and capable of providing a decent living. As a cultural heritage, however, sawah surjan has been under an increasing threat of conversion resulting from the infrastructure development and spreading of urban developments. This study assessed the prospect of sawah surjan in the rural household economy and its sustainability within the context of changing wider environment. To do so, a household survey was conducted covering 41 farmer households in Depok Village, Panjatan Sub-district, Kulonprogo Regency, Yogyakarta Special Province where the existence of sawah surjan is threatened by the large-scale investments. The research show that sawah surjan contributes to employment generation, diverse sources of income, food security, and income redistribution. It is generally sustainable but the excessive use of pesticides and chemical fertilizers will have adverse effects on its sustainability. The research confirms that the most significant threat is the infrastructural development, especially the prospective construction of a new international airport as increased land prices may lead to uncontrolled conversion of sawah surjan into non-agricultural uses. This is also in coincidence with the stagnant regeneration of farmers in the area that lead to a bleak future of the system.
The Influence of Madden–Julian Oscillation on Local-Scale Phenomena over Indonesia during the Western North Pacific and Australian Monsoon Phases
Authors: Pramuwardani Ida , Hartono Hartono , Sunarto Sunarto , Sopaheluwakan Ardhasena
Published: December 2018

In this study, geographical Madden–Julian oscillation (MJO) propagation in association with precipitation rate was obtained using lag correlation applied to empirical orthogonal function (EOF) analysis modes 1 and 2 of filtered MJO data. The precipitation rate over Indonesia was provided at day -10 through day +10 in five-day steps during the December, January, and February (DJF) Western North Pacific (WNP) and July, August and September (JAS) Australian (AU) monsoon phases. Connection with local atmospheric factors was then sought through comparison of local precipitation, represented by 3-hourly precipitation, and dynamical processes, represented by multilevel wind, at seven locations across Indonesia. The results show a global MJO contribution toward local-scale phenomena in Tangerang, Surabaya, and Makassar during the DJF-WNP monsoon phase and in Padang, Medan, Surabaya, Makassar, and Kupang during the JAS-AU monsoon phase. Meanwhile, a lack of MJO contribution toward local factors is presumably due to other local through wider atmospheric-scale phenomena which are suspected to have more influence, particularly in Medan, Padang, Manado, and Kupang during the DJF-WNP monsoon phase, and in Manado and Tangerang during the JAS-AU monsoon phase. This research uses a dataset of 15-year series of daily and three-hourly Tropical Rainfall Measuring Mission (TRMM) (3B42 V7 derived) measurements, 850 hPa zonal wind measurements from 30-year reanalysis data from the ERA-Interim reanalysis dataset, and a 15-year series of 12-hourly observational soundings data from seven stations of the Indonesian Meteorological Climatological and Geophysical Agency (BMKG).
Validation of Satellite Daily Rainfall Estimates Over Indonesia
Authors: Fatkhuroyan Fatkhuroyan , Wati Trinah , Sukmana Alfan , Kurniawan Roni
Published: December 2018

Rainfall is the most important factor in the Earth’s water and energy cycles. The aim of this research is to evaluate the accuracy of Global Satellite Mapping of Rainfall (GSMaP) data by referencing daily rain-gauged rainfall measurements across the Indonesian Maritime Continent. We compare the daily rainfall data from GSMaP Moving Kalman Filter (MVK) to readings from 152 rain-gauge observation stations across Indonesia from March 2014 to December 2017. The results show that the correlation coefficient (CC) provides better validation in the rainy season while root mean square error (RMSE) is more accurate in the dry season. The highest proportion correct (PC) value is obtained for Bali-NTT, while the highest probability of detection (POD) and false alarm ratio (FAR) values are obtained for Kalimantan. GSMaP-MVK data is over-estimated compared to observations in Indonesia, with the mean accuracy for daily rainfall estimation being 85.47% in 2014, 85.74% in 2015, 82.73 in 2016, and 82.59% in 2017.
Spatial Analysis and Visualization of Geographic Access to Food in the Capital Area of Bulungan Regency, North Kalimantan Province
Authors: Susilo Bowo , Harini Rika
Published: December 2018

Recently, food security becomes a priority for many governments particularly in developing countries. Food security has four dimensions i.e. availability, accessibility, stability, and utilization. This study examined food accessibility in term of geographic access i.e. the contribution of the geographic environment to food choices and consumption. The study located in Tanjung Selor Subdistrict, the capital region of Bulungan Regency as well as North Kalimantan Province. Geographic access to food was analyzed based on spatial distribution of food stores, settlement, and availability of transportation network. Spatial analysis, i.e. coverage, density, and network analysis, as well as the spatial visualization were performed using tools available in GIS software. This study revealed some circumstance related to geographical access to food in the study area. Geographical access to food for non-motorized people is limited. Non-motorized people have to walk more than 1 km to the nearest food store. Access to food for motorized people is somewhat different. Their geographical access, in general, were categorized as easy to moderate. This situation indicates that the availability of public transport or vehicle ownership is necessary to improve access to food.
Donald Trump dan Berita Imigran di Aljazeera.com dan Foxnews.com
Authors: Anggoro Ayub Dwi , Purwati Eli , Hilman Yusuf Adam
Published: December 2018

Donald Trump’s policy on immigrants has been a controversy. The controversy culminated when the policy was reported by the media, such as Foxnews.com and Aljazeera.com. This study aims to compare news framing in both media, especially the application of ideology and political economic of media, as an effort to get objective and neutral reporting. This research uses qualitative approach with framing analysis method of Zhongdang Pan and Gerald M. Kosicki. The results show that framing by Foxnews.com and Aljazeera.com is in favor of the interests of media owners, namely Rupert Murdoch and the government of Qatar.
Intercultural Communication of Indian Cultural Dimensions Through Indonesian Secretary’s Perspective
Authors: Silintowe Yunita Budi Rahayu , Susanto Annie
Published: December 2018

The purpose of this research is to analyze the business communication between Indonesian secretaries and expatriate leaders from India in multinational companies. It is a descriptive qualitative research, using interview and FGD. The findings of this reserach, according to Trompenaars’ Cultural Dimensions, shows that the Indian expatriate leaders and Indonesian secretaries have differences in two dimensions, Neutral-Emotional and Achievement-Ascription. If those cultural differences are ignored, they may be potential creating interference in the

communication process.
Students’ Ability In Solving Physics Problems on Newtons’ Law of Motion
Authors: Supeno Supeno , Subiki Subiki , Rohma Laili Widya
Published: December 2018

The ability to solve physics problems is one of the goals in learning physics and a part of the current curriculum demands. One of the physics problems that are often the focus of attention in learning is Newton's law of motion. When solving physics problems on Newton's law of motion, students need to utilize various aspects of certain abilities and rules. The purpose of this study was to reveal how the students utilized aspects of the abilities and rules in problem-solving. The study was conducted by providing physics problems on Newton's law of motion to 105 high school students. The result showed that most students were able to write equations, solutions, and system of units correctly for each problem. However, students’ ability to determine the coordinate axes, depicts free-body diagrams, forces representation, and determine the resultant forces and direction of motion was unsatisfactory. Students tended to refer to the mathematical formulations in solving the problems. Therefore, physics learning that requires students to actively learn collaboratively, peer instruction, and procedural thinking can be used as an alternative learning strategy to overcome said problems.
2D Interpretation of Subsurface Hot Spring Geothermal Structure in Nyelanding Village Through Schlumberger Geoelectricity Configuration Method
Authors: Siregar Rahmat Nawi , Kurniawan Widodo Budi
Published: December 2018

This research was done on the subsurface structure of Nyelanding village hot spring, Air Gegas district, South Bangka with coordinates 2 44’54.514” South Latitude and 106 16’6.773” East Longitude using the Schlumberger geoelectricity configuration method. Measurements were made on three different tracks. The results of the Schlumberger configuration geoelectricity measurements for the three trajectories indicate the presence of granite rock distribution with resistivity values ranging from 455 – 1046 m.
Developing Physics Monopoly Game Learning Media for Light and Optical Devices
Authors: Sari Aprilia Mayang , Gunawan Indra
Published: December 2018

This study aims to determine the specific needs, feasibility, and responses of teachers and students toward the developed physics learning media of monopoly game on the light and optical devices material. The research procedure was based on the 4-D model. The subjects of this study were the students of State Junior High School 2 Gadingrejo. Data was collected through questionnaire. The data collected were analyzed using descriptive statistics. The results of this study were; 1) to know the specific needs in the form of filters by researchers to eliminate, replace, or modify the various components of the game into educational elements and the need for materials such as paper art paper and linen suitable for printing monopoly game designs; 2) to know the media feasibility through media and material expert’s judgement. The average scores gained through the expert judgment were 4.45 and 4.24 respectively that fall into a very high category; 3) Teacher and student responses fall into the very high category with the mean score of 4.24 from teachers, 4.53 from small group testing and 4.59 from field-testing
Development of LCDS-Based Interactive Electronic School Book on Blackbody Radiation as Self-Instructional Materials for Fostering Student’s Critical Thinking
Authors: Ayuningtias Meta Dwi , Suyatna Agus , Suyanto Eko , Nwineh Legborsi
Published: December 2018

This study aims to develop an LCDS- based the interactive electronic school book on blackbody radiation that is valid as self-instructional materials to foster students' critical thinking skills. The method used was research and development. The stages of the research were determining the existing potentials and problems, information gathering, product design, product validation, the final revision of the product, and feasibility tests and practicality of operation. The research instrument used was a questionnaire. Interactive electronic school book has supporting contents, namely user manual, user learning process, video, animation, simulations, and interactive tests. Expert test for product consists of content validation with the score of 3,36 (very appropriate) and design validation with the score of 3,45 (very appropriate). Readability of LCDS- based interactive electronic school book on blackbody radiation got the score of 3, 23 which belongs to the good quality. The practicality aspects got a score of 3.28 which means it can be operated independently
One Dimensional Motion with ICT Based Learning: Improving the Physics Teacher Candidates’ Science Process Skills and Attitudes
Authors: Nuryantini Ade Yeti , Mahen Ea Cahya Septia
Published: December 2018

Education nowadays is demanded to produce students who have beneficial skills of the 21st century in dealing with problems in the era of information and digital technology. Therefore, it is necessary to change the emphasis of learning patterns. In this paper, the results of the application of 21st-century skills in learning Basic Physics 1 in the Physics Education Study Program, UIN Sunan Gunung Djati Bandung using a scientific approach is presented. Learning activities were conducted based on low budget materials and ICT in the form of tracker software. The results showed that students were skilled in using tracker (90%), had science processing skills (excellent 5.2%, good 74.0%, and fair 20.8%), and fostered curiosity (92.0%), careful attitude (92.2%), caring for the environment (73.0%), honest (93.0%), and cooperative (97.0%)
Brecha digital e inclusión digital: fenómenos socio – tecnológicos
Authors: Sepúlveda López Jheimer Julián , Ramírez Castañeda Luz Arabany
Published: December 2018

Existe una diferencia entre comunidades respecto al acceso y uso de herramientas tecnológicas para satisfacer necesidades y mejorar condiciones de vida; fenómeno definido como brecha digital. Para reducir dicha diferencia se emprenden propuestas y procesos en el marco del fenómeno denominado inclusión digital.Se ha identificado que estos dos fenómenos integran aspectos sociales y tecnológicos que deben ser considerados al momento de implementar los programas y proyectos.Adicionalmente, se considera que la Administración de Sistemas Informáticos es un área disciplinar que integra conocimientos necesarios para estudiar dichos fenómenos. La administración es una disciplina de las ciencias sociales y los sistemas informáticos son productos que se desarrollan en el marco de las ciencias exactas.En el presente documento se plantea la relación entre la Administración de Sistemas Informáticos y el estudio (análisis, mejora, diseño y propuesta) de los fenómenos de la brecha e inclusión digital.
Alcohol consumption by the drivers as a risk factor in public transport
Authors: Płachecka Magdalena
Published: December 2018

Issues to do with driving vehicles after drinking alcohol as well as being in a state of intoxication have been the object of interest in units, institutions, organs of public administrations, which carry out actions to increase the safety of road traffic in Poland. The aspect of drunk driving should be considered on the public heath spectrum, as a result of accidents caused by drunk driving hundreds of people die and thousands are left severely injured. In order to build awareness among people driving motor vehicles, programs, initiatives and different promotion actions are introduced to raise the importance of not driving after drinking alcohol. The purpose of this article is to present and assess actions made to improve the safety of people participating in road traffic with particular emphasis on public transport, eg. buses. The actions and initiatives taken at the national level have been discussed which will improve and increase road  safety.