bluuebunny/crossref_metadata_2025 huggingface dataset:
A Study on the Informal Learning Process in an Online Community
Authors:   Human Engagement Institute, Kwon Hyun G , Lee Jaeyong , Jang Hwan Young
Published: October 2023

This study provides a conceptual framework for the informal learning process in an online community. We conducted in-depth interviews with 11 community members and analyzed the data based on grounded theory. The study results are as follows: First, the causal conditions are ‘high intellectual growth desire, competent group members, interesting academic field, recommendation from trusted members,’ and the contextual condition is ‘lack of learning opportunities.’ Second, the core phenomenon is ‘intellectual play and reflection by observation.’ Third, the intervening conditions are a ‘humane atmosphere, unconscious sense of responsibility,’ and the strategies for action and interaction are ‘sustainability and transfer of learning, questions that provoke joint participation, fair regulation of speaking rights.’ Fourth, we analyzed the outcomes as ‘holistic growth experience, synchronization of passion, serendipitous insight, and abundant mindset.’ Based on the selective coding, the informal learning process consists of three stages: ‘enthusiasm and respect atmosphere’ for the early stage, ‘play and reflection’ for the mid stage, and ‘growth experiences and abundant mindset’ for the late stage. The core category is integrated as ‘limitless learning by intellectual play’. We discuss practical suggestions for informal learning in the online community.
Marka Deneyiminin Davranışsal Niyet Üzerindeki Etkisi
Authors: DAĞ Kazim
Published: October 2023

Marka araştırmacıları, tüketicilerin markaları nasıl değerlendirdiklerini ve marka uygulamalarına nasıl tepki verdiklerini anlama arayışı içindedirler. Bu arayış, deneyimlerin tüketici davranışı üzerinde önemli bir etkiye sahip olmasından kaynaklanmaktadır. İşletmeler bir pazarlama stratejisi olarak müşteri kazanmak için markalarla ilgili deneyimlere odaklanma eğilimindedir. Çünkü bu deneyimler tüketicileri sosyal, duyusal ve davranışsal olarak etkilemektedir. Tüketicilerin markayla ilgili deneyimlerine ilişkin algısı olan marka deneyimi, davranışsal niyeti etkileyebilmektedir. Marka deneyimi, işletmelere müşterileri için keyifli bir deneyim için müşteri-marka etkileşimini kullanarak birçok fırsat sağlamaktadır. Bir marka ile deneyim, ürün özellikleri ve faydalarından daha fazla etkiye sahiptir ve marka deneyimi uzun vadeli tüketici-marka ilişkisi kurmada önemli bir stratejik faktör olarak değerlendirilmektedir. Bu nedenle marka deneyiminin yarattığı değerin davranışsal niyeti etkileyerek tekrar ziyaret, tavsiye ve daha fazla ödemeye yol açması olumlu ya da olumsuz etkilenebilmektedir. Dolayısıyla tüketici ihtiyaçlarını daha iyi anlayarak marka deneyimini yönetmek işletmelerin stratejik birtakım avantajlar elde etmesini sağlayacaktır. Bu çalışma, tüketicilerin marka deneyiminin, davranışsal niyet üzerindeki etkisini incelemeyi amaçlamaktadır. Araştırmada örnekleme yöntemi olarak “kolayda örneklem” yöntemi kullanılmıştır. Veriler, restoran müşterilerinden anket tekniği kullanılarak toplanmıştır. Araştırmada hipotezlerin test edilmesi için Smart PLS 4 istatistik programı kullanılmıştır. Yapılan testler sonucunda, marka deneyimi boyutları olan duyusal, duygusal, davranışsal ve entelektüel deneyimin davranışsal niyet boyutlarını (tekrar ziyaret, tavsiye, daha fazla ödeme) olumlu etkilediği görülmüştür. Ancak entelektüel deneyimin, tavsiye ve daha fazla ödeme niyetini olumlu etkiler hipotezlerinin desteklenmediği belirlenmiştir.
Gümrük Birliği Anlaşmasının Türkiye’ye Etkileri: Gelinen Aşamada Devam mı Tamam mı ?
Authors: ASLAN Ramazan
Published: October 2023

Dünya genelinde özellikle de II. Dünya Savaşı sonrasında hem küreselleşmenin yaygınlaşmaya başlaması hem de ticaretin serbestleşmesi ve çatışmaların azalması amacıyla, ekonomik alanda çeşitli entegrasyonlar oluşmaya başlamıştır. Bu tür entegrasyonlar vasıtasıyla ülkeler hem kaynak verimliliğini artırmaya çalışmakta hem de daha büyük bir pazara hitap ederek küresel çapta avantajlar elde etmeyi amaçlamaktadır. Söz konusu entegrasyonların en yaygın olanı ise gümrük birliği olmuştur. Türkiye ekonomik ve siyasi tercih olarak bu entegrasyonların en önemlilerinden olan AB’ye yönünü dönmüş ve 1963’te Ankara Anlaşması’nı imzalamıştır. İnişli çıkışlı geçen süreç sonunda 1996’da AB ile Gümrük Birliği Anlaşması yapılmıştır. AB’ye tam üye olmadan GB imzalayan yegâne ülke olan Türkiye’nin özel durumu dikkate alındığında, asıl amacın GB’den daha ileri giderek AB’ye tam üyelik olduğunun göz ardı edilmemesi gerekir. Gümrük Birliği’nin ekonomik etkileri GSYİH üzerinde tek seferlik ortaya çıkan statik etkiler ile süreklilik gösteren dinamik etkiler olmak üzere iki ana başlıkta incelenmektedir. Söz konusu etkilerin Türkiye için nasıl geliştiğini görmek amacıyla Türkiye’nin dış ticaret verileri ve Türkiye ile AB arasındaki dış ticaret rakamları incelenmiştir. Neticede, statik etkilerinin negatif, dinamik etkilerinin ise genelde pozitif olduğu görülmüştür. Bu tespitler çerçevesinde Gümrük Birliği Anlaşması, statik etkiler üzerinden kimi kesimlerce eleştirilirken, genelde pozitif olan dinamik etkiler üzerinden de çoğunlukla destek bulmuştur. Bu noktada Gümrük Birliği Anlaşması sonrasında her iki etkinin toplamının Türkiye ekonomisine katkısının ne yönde olduğu önemli görülmektedir. Bu doğrultuda hem Türkiye hem de dünya ekonomisinde yaşanan gelişmeler çerçevesinde, gelinen aşamada Gümrük Birliği Anlaşmasının revize edilmeye muhtaç duruma geldiğini belirtmek gerekir.
Uluslararası Barış ve Güvenliğin Korunmasında Birleşmiş Milletlerin Rolü: Bağımsızlıktan Bölünmeye Sudan Örneği (1956 – 2011)
Authors: KARAKAYA İskender , ORALLI Levent Ersin
Published: October 2023

Afrika’nın en büyük ülkelerinden birisi olan Sudan, İngiliz sömürge dönemi sonrası 1956 yılında bağımsızlığına kavuşmuştur. Bağımsızlık sonrası gerek sömürgecilik döneminden gelen sorunlar gerekse de siyasi çekişmeler, etnik (Arap-Afrikalı) ve sosyo-kültürel (din, bölgesel milliyetçilik ve kabilecilik) sorunlarla istikrarsız dönemler, iç savaşlar ve çekişmeler yaşamıştır. Kuzey (hükümet güçleri) ve Güney (Sudan Halk Özgürlük Hareketi vd.) arasındaki iç savaş ve Darfur’da meydana gelen çatışmalar sonucu birçok insan ölmüş ya da zarar görmüştür. Sudan’da yaşanan bu süreç BM ve diğer uluslararası örgütlerin Sudan ile ilgilenmelerine yol açmış ve 2005 yılında yapılan Kapsamlı Barış Antlaşması ile 2011 yılında düzenlenen referandumla Güney Sudan bağımsızlığını kazanmıştır. Ancak bu referandum süreci çok kolay olmamış Sudan’da BM, 2000 yılı sonrası aldığı kararlar ve oluşturduğu misyonlarla uluslararası barış ve güvenliği sağlama adına yoğun çabalar sarf etmiştir. Kuzey ve Güney arasındaki çatışmaların, ölümlerin ve insani krizlerin engellenmesi için güvenlik konseyinde birçok karar alınmış, UNAMIS, UNMIS misyonları oluşturulmuş, özel temsilciler atanmıştır. Barış süreçleri, idari önlemler, güvenlik önlemleri ve insani yardımları içeren bu önlemlere rağmen Sudan’ın yapısı korunamamış ve 2011 yılında düzenlenen referandumla ülke ikiye bölünmüştür. Birleşmiş Milletler (BM)’in Sudan’daki misyonunun nasıl başlayıp ilerlediği detayları ile ele alınacağı bu makalede BM’nin, Sudan’da uluslararası barış ve güvenliği sağlama çabalarının başarısız olduğu bunun sonucu olarak da Sudan’ın 2011’de ikiye bölündüğü hipotezi öne sürülmektedir. Çalışmada, Sudan’daki uluslararası güvenlik ve barışı sağlama süreci tarihsel, hukuki, sosyo-kültürel ve güvenlik boyutları ile ele alınmıştır.
Velilerin Gözünden 4-6 Yaş Kur’an Kursları Üzerine Bir Meta-Sentez Çalışması
Authors: ECER Münir
Published: October 2023

Bu çalışmada Diyanet İşleri Başkanlığı’na bağlı olarak 2013 yılından beri faaliyet yürüten 4-6 yaş Kur’an kurslarına ilişkin veli görüşlerine yönelik çalışmaların merkeze alınarak meta-sentez yöntemiyle incelenmesi ve bu görüşlerin genel bir değerlendirmesinin elde edilmesi amaçlanmıştır. Türkiye’nin farklı bölgelerinde yürütülen veli görüşlerine dayalı 4-6 yaş Kur’an kursu çalışmalarında hem benzer hem de farklı bulgu ve sonuçlar elde edilmiştir. Çalışmada bilimsel yöntem olarak kullanılan meta-sentez, nitel araştırmalarda giderek araştırma sayısı artan bir konuya ilişkin bulgu ve sonuçları bir araya getirip analiz eden ve genel bir değerlendirmenin elde edilmesini sağlayan bir özellik taşımaktadır. Bu yöntemi kullanarak Türkiye’de 4-6 yaş Kur’an kurslarına çocuklarını gönderen velilerin görüşlerini içeren çalışmaların veri ve sonuçları ile ilgili genel bir panoramanın elde edilebileceği düşünülmüştür. Çalışma grubunda toplam 10 araştırma yer almıştır. Bunlar araştırmacı tarafından taranarak kodlandırılmış daha sonra da temalara ulaşılmıştır. Ulaşılan temalar; kursu tercih gerekçesi, içerik, kazanımlar, fiziksel koşullar ve öğretici yeterliğidir. Elde edilen sonuçlara göre veliler dinî eğitim başta olmak üzere resmî kurum, tavsiye, sosyalleşme, örgün eğitime hazırlık gibi gerekçelerle çocuklarını bu kurslara göndermektedir. Kurslarda verilen eğitimin içeriği ve öğrencilerin edindiği kazanımlarla ilgili bulgular, velilerin genel anlamda memnuniyetini ortaya koymakla beraber çeşitli problemlerin de ifade edilmesini sağlamıştır. Kursların fiziksel koşullarına ilişkin verilerin bir kısmı yeterli olduğu yönünde sonuçlar verirken elverişsiz ve iyileştirilmesi gereken yönlere de işaret etmiştir. Son olarak velilerin gözünden kursların öğreticilerinin alan bilgisi ve pedagojik donanımları genel anlamda yeterli görülmüş, bununla beraber bazı iletişim ve iş birliği eksikliklerine de temas edilmiştir.
Effect of the Synthesis Parameters on the Physicochemical Properties and Photocatalytic Performance of Nb2O5 to Water Treatment and H2 Production
Authors: Souza Marlete , Bernardo Marcela , Alves Higor , Silva Cleiton , Patrocínio Antônio Otávio , Lopes Osmando
Published: October 2023

Nb2O5 is a promising photocatalyst for degradation of organic pollutants and production of H2 (renewable and green fuel) from water is an alternative to overcome environmental and energy concerns. Therefore, the effect of Nb precursor and synthesis method on the Nb2O5 physicalchemical properties and photocatalytic performance were investigated in this work. X-ray diffraction and Raman spectroscopy results showed that synthesis parameters had a significant impact on the structural properties of the materials obtained. The synthesis parameters were able to tune Nb2O5 crystalline phase, morphology and specific surface area. Nb2O5 sample obtained by hydrothermal method resulted in materials with smaller size and homogeneous particles compared to the other samples, which resulted in a higher specific surface area (200 m2 g-1) and surface hydroxylation. Nb2O5 samples were active to promote both the degradation of Rhodamine B and amiloride, the specific surface area and surface hydroxylation play a key role in the performance of the materials. The most active sample for organic pollutant degradation was also active in H2 production, additionally, the decoration with Pt nanoparticles increased its performance. This work describes the effect of synthesis parameters of Nb2O5 on its photocatalytic properties and demonstrates the potential application of this material in heterogeneous photocatalysis.
Use of Data to Generate Economic Benefit and Property Rights
Authors:   European Constitutional Law Association, Jung Aeryung
Published: October 2023

Car rental companies are earning revenue by selling driving data and transforming into mobility companies that collect data beyond the car rental business. The paradigm shift in the economy and society has already begun with the convergence of disparate sciences and technologies, aiming to create new businesses that combine existing industries and data in the digital transformation. All government ministries are calling for a paradigm shift in the digital transformation for economic and social development, and the keyword mentioned for this is the analysis and utilization of data. In recent years, the amount of data generated by humans and objects has increased exponentially, and it is clear utilizing data to unleash the social and economic potential of data will greatly help economic development. However, when it comes to harnessing the economic utility value of data, there is a need to discuss who has the right to the data and how the benefits should be distributed. It is not clear who owns the data and how it will be protected, not only for data generated by individuals but also for data collected by machines or online services. On the one hand, data should be freely circulated to create economic value, and on the other hand, it contains objects that need to be protected, such as personal information and intellectual property, and the value of reuse and utilization of collected data is great, but since aggregated data is concentrated in a few giant companies, legal, institutional, and technical measures are needed to utilize data fairly.
Data is produced by a variety of entities, and in some cases, the entity that produces the data and the entity that has the right to process the data are separated. Depending on the type of data, personal information, which emphasizes the control of the information subject, non-personal information, which is de-identified, and data collected from products have different characteristics. However, in this paper, I have attempted to approach each data as an object of property rights under the premise of recognizing its economic value. In the case of personal information, which is considered to be subject to protection, the effect of strengthening the control of the information subject can be expected when it is recognized as a subject of transaction, and in the case of other industrial data, it is necessary to clarify the right to profit sharing for the creation of economic value. The EU data law takes a contractual approach to the allocation of data, an important resource in the digital economy. We hope that the EU Data Act will help us to refine our legislation, and we should continue to seek ways to promote the fair and safe use of data and revitalize the data economy.
The Fair Balance Test of European Court of Human Rights
Authors:   European Constitutional Law Association, Lee Jaehong
Published: October 2023

The proportionality plays an important role in the case law of Europenan Court of Human Rights. The Court’s proportionality test is classified as a ‘horizontal’ proportionality test, setting it apart from the vertical proportionality test used by the Constitutional Court of Korea. The horizontal proportionality test of the European Court of Human Rights does not adhere to any particular order of assessment but instead focuses its reasoning on a fair balance test. The fair balance test is similar to the fourth prong of proportionality test of the Korean Constitutional Court. The essence of proportionality, from a theoretical standpoint, lies in determining whether the specific level of restriction on a right is worth being endured compared to the degree of benefits achieved by the actions of public authorities. In the jurisprudence of the European Court of Human Rights, the fair balance test perform this balancing task. Hence, the European Court of Human Rights' reasoning structure, which places a fair balance at its core, is theoretically sound. In applying the fair balancing test, the European Court of Human Rights considers not only the relevance to the fundamental values of the European Convention on Human Rights but also various specific circumstances of each case. This enables the Court to assess the concrete importance of the rights guaranteed by the Convention and the concrete value of the measures taken by member states, moving beyond their abstract value. While the European Court of Human Rights applies the “margin of appreciation” doctrine in their assessment of the fair balance, the reasoning structure still remains within the framework of a balancing test. The Constitutional Court of Korea also considers the balance of interests, although decisions where this prong predominate are rare. Nevertheless, there have been recent decisions that demonstrate a dedicated commitment to the balance of interests, both quantitatively and qualitatively. This new trend is commendable, both from a theoretical perspective and in comparison to the practices of the European Court of Human Rights.
Introduction To Cloud Computing and AWS
Authors: Dubey Parul , Kumar Tiwari Arvind , Raja Rohit
Published: October 2023

This chapter offers an in-depth exploration of cloud computing,
encompassing various deployment models and services. It sheds light on the pressing
concern of personal data privacy, as cloud technology enables data to traverse
geographical boundaries, disregarding local regulations. The evolution of AWS since
2000 takes the center stage, emphasizing key elements such as regions, availability
zones, and data centers. By providing comprehensive insights, the chapter equips users
with the necessary knowledge to effectively navigate the intricacies of AWS. It also
elucidates the AWS shared responsibility model, ensuring users understand their own
responsibilities and those of AWS. Furthermore, the chapter focuses on six core
competencies, enabling customers to fully harness the potential of AWS's offerings.
This multifaceted chapter serves as a comprehensive guide, empowering readers to
grasp the complexities and opportunities of cloud computing with AWS.
Identity and Access Management in AWS
Authors: Dubey Parul , Kumar Tiwari Arvind , Raja Rohit
Published: October 2023

This chapter provides a comprehensive exploration of Identity and Access
Management (IAM) in AWS. It delves into the detailed processes of creating IAM
users, roles, and setting policies, emphasizing their significance in safeguarding the
AWS account and its users. IAM proves invaluable in managing multiple users within
a single account. The chapter also highlights the crucial role of Multi-Factor
Authentication (MFA) in enhancing account security, particularly when collaborating
with AWS Cloud Service Providers (CSP). Overall, this chapter serves as a
fundamental guide for understanding and implementing IAM, establishing a strong
foundation for working effectively within the AWS ecosystem.
Load Balancing and Auto Scaling in AWS
Authors: Dubey Parul , Kumar Tiwari Arvind , Raja Rohit
Published: October 2023

This chapter provides a thorough introduction to Autoscaling and Elastic
Load Balancing (ELB) in the AWS cloud. It highlights the benefits of these services,
which simplify workflows and automate tasks. The chapter offers an in-depth overview
of ELB and Autoscaling, covering their basic uses and providing hands-on experience.
By understanding and utilizing these services, users can optimize resource allocation,
handle traffic fluctuations, and enhance application performance. This chapter serves as
a comprehensive guide for effectively implementing Autoscaling and Elastic Load
Balancing in the AWS environment.
Cloud Monitoring
Authors: Dubey Parul , Kumar Tiwari Arvind , Raja Rohit
Published: October 2023

This chapter provides a comprehensive exploration of Amazon Web
Services (AWS) monitoring. It focuses on AWS CloudWatch and associated logs,
covering various aspects in detail. The chapter includes step-by-step instructions for
setting up CloudWatch alarms, working with CloudWatch logs, and monitoring
CloudTrail. Furthermore, the chapter delves into the AWS health check feature,
providing a deeper understanding of its significance. It highlights the importance of
both private health checks and the Service Health Dashboard, emphasizing their role in
ensuring system reliability and performance. By studying AWS monitoring tools and
features, readers gain insights into effectively monitoring their AWS resources and
applications. This chapter serves as a valuable resource for understanding and
implementing CloudWatch, CloudTrail, and AWS health checks, enabling users to
maintain a proactive and robust monitoring approach within the AWS environment.
Amazon Web Services: the Definitive Guide for Beginners and Advanced Users
Authors: Dubey Parul , Kumar Tiwari Arvind , Raja Rohit
Published: October 2023

Amazon Web Services: A Comprehensive Guide for Beginners and Advanced Users is your go-to companion for learning and mastering AWS. It presents 10 easy-to-read chapters that build a foundation for cloud computing while also equipping readers with the skills necessary to use AWS for commercial projects. Readers will learn how to use AWS cloud computing services for seamless integrations, effective monitoring, and optimizing cloud-based web applications.

What you will learn from this guide:

1. Identity and Access Management in AWS: Learn about IAM roles, security of the root account, and password policies, ensuring a robust foundation in access management.

2. Amazon EC2 Instance: Explore the different types of EC2 instances, pricing strategies, and hands-on experiences to launch, manage, and terminate EC2 instances effectively. This knowledge will help to make informed choices about pricing strategies.

3. Storage Options and Solutions: A detailed examination of storage options within Amazon EC2 instances. Understanding Amazon Elastic Block Store (EBS), Amazon Elastic File Storage (EFS), and more, will enhance your ability to handle data storage efficiently.

4. Load Balancing and Auto Scaling: Learn about different types of load balancers and how auto-scaling groups operate, to master the art of managing varying workloads effectively.

5. Amazon Simple Storage Service (S3): Understand S3 concepts such as buckets, objects, versioning, storage classes, and practical applications.

6. AWS Databases and Analytics: Gain insights into modern databases, AWS cloud databases, and analytics services such as Amazon Quicksight, AWS Glue, and Amazon Redshift.

7. Compute Services and Integrations: Understand the workings of Docker, virtual machines, and various compute services offered by AWS, including AWS Lambda and Amazon Lightsail, Amazon MQ and Amazon SQS.

8. Cloud Monitoring: Understand how to set up alarms, analyze metrics, and ensure the efficient monitoring of your cloud environment using Amazon CloudWatch and CloudTrail.

Key Features:

Comprehensive Introduction to Cloud Computing and AWS
Guides readers to the complete set of features in AWS
Easy-to-understand language and presentation with diagrams and navigation guides
References for further reading

Whether you're a student diving into cloud specialization as part of your academic curriculum or a professional seeking to enhance your skills, this guide provides a solid foundation for learning the potential of the AWS suite of applications to deploy cloud computing projects.
Mulheres viajantes no Estado Novo
Authors: Serrano Sónia
Published: October 2023

This communication has Portugal as its socio-political setting, between the 1930s and 1960s, and focuses on the study of eight travel books written by women, two of them co-authored with male authors. The analysis is based on a gender perspective, and seeks to reflect on the impact of the ideological propaganda disseminated by the Estado Novo, within travel narratives, and how it permeated the discourses made about the country and the people. The reading of these texts from a joint perspective offers us a series of questions that seem interesting to address, of which I will highlight one, the idea of the exotic related to the Portuguese culture of the time, in a perspective of analysis of a country subject to the gaze of the foreign visitor and who was trying to stage a new era in its history.
СОНОГРАФІЧНІ ОЗНАКИ ЗМІН ЛЕГЕНЬ ТА НИРОК ПРИ НОВІЙ КОРОНАВІРУСНІЙ ХВОРОБІ-2019 У ВАГІТНИХ З ФЕТОПЛАЦЕНТАРНОЮ НЕДОСТАТНІСТЮ
Authors: Мацькевич Вікторія , Х. М. Ільницька  , О. Я. Царук  , І. С. Головчак  , О. Г. Бойчук  , Т. Л. Ленчук  , Л. В. Глушко
Published: October 2023

Ультразвукове дослідження є основним методом діагностики змін легень і нирок у вагітних пацієнток з новою коронавірусною хворобою-2019. Метою дослідження є підвищення діагностичних можливостей виявлення змін легень та нирок, спричинених вірусом SARS-CoV-2 у вагітних з фетоплацентарною недостатністю у другому триместрі вагітності на підставі клінічних та ультразвукових ознак. У групу дослідження увійшли 42 пацієнтки віком 31-41 років, а у контрольну групу - 40 вагітних віком 29-40 років. Методи дослідження включали сонографічне обстеження легень та нирок, а також аналіз клініко-інструментальних даних. У 24 вагітних (57,1%) з фетоплацентарною недостатністю ультразвукові зміни легеневої тканини при коронавірусній хворобі-2019 представлені потовщенням і деформацією плевральної лінії, зливними В-лініями, транслобарною консолідацією з переважним ураженням нижніх долей легень. При сонографічному обстеженні нирок структурних змін паренхіми не виявлено, порожниста система не поширена.

     Ключові слова: вагітність, фетоплацентарна недостатність, доплерографія, ультразвукове дослідження, коронавірусна хвороба-19, вірус SARS-CoV-2, пневмонія, легеневі хвороби.
ЕФЕКТИВНІСТЬ ЗАСТОСУВАННЯ L-КАРНІТИНУ ДЛЯ КОРЕКЦІЇ МЕТАБОЛІЧНИХ ПОРУШЕНЬ У ДІТЕЙ, ОПЕРОВАНИХ З ПРИВОДУ ВРОДЖЕНОЇ КОЛОРЕКТАЛЬНОЇ ПАТОЛОГІЇ
Authors: В.О. Фофанов  , О.Д. Фофанов  , А.Б. Волосянко  , А.П. Юрцева  , І.М. Дідух
Published: October 2023

Актуальність проблеми вродженої колоректальної патології (ВКРП) у дітей, до якої відносять хворобу Гіршпрунга (ХГ) та аноректальну мальформацію (АРМ), зумовлена значною кількістю ранніх та віддалених післяопераційних ускладнень, які можуть вимагати тривалого лікування, повторних реконструктивних операцій. Це питання має важливе медико-соціальне значення, що пов’язано, перш за все, зі значним розповсюдженням ХГ та АРМ, частим поєднанням з іншими вадами, виразним тривалим погіршенням якості життя у хворих  дітей. При абдомінальній хірургічній патології, зокрема при ВКРП, внаслідок хірургічної травми та периопераційної нутрієнтної недостатності ймовірність розвитку метаболічних розладів та енергодефіциту є досить високою. Беручи до уваги дезінтоксикаційний, антигіпоксичний та антиоксидантний ефекти L-карнітину, з метою корекції виявлених метаболічних порушень та енергодефіциту призначають  L-карнітинвмісн препарати. В умовах недостатнього харчування у дітей з ВКРП, зумовленим основним захворюванням, дефіцит L-карнітину у дітей з цією патологією,  є цілком можливим. Дані фундаментальних досліджень останніх років показали, що корекція метаболічних порушень і енергопротекція – це  прогресивний  напрямок, якому  належить майбутнє. Метою дослідження є оцінка впливу застосування L-карнітинвмісного препарату  на клінічний перебіг післяопераційного періоду та показники редокс-системи глутатіону і метаболітів енергетичного обміну у дітей з вродженою колоректальною патологією. У дослідження включено 57 пацієнтів з ВКРП, розділених на дві групи: основна – 30 дітей з ВКРП, які в післяопераційному  періоді отримували базову реабілітаційну терапію та L-карнітинвмісний препарат  Агвантар; група порівняння – 27 пацієнтів, які отримували  лише симптоматичну та базову реабілітаційну терапію.  Контрольну групу склали 20 дітей того ж віку, які протягом остнніх 2 місяців не хворіли на інфекційно-запальні захворювання.  В обох групах пацієнтів, які  ввійшли в дослідження, проводили оцінку показників редокс-системи глутатіону та метаболітів енергетичного обміну в динаміці через 1 місяць після оперативного втручання.  Під впливом застосування L-карнітинвмісного препарату встановлена позитивна динаміка клінічного перебігу  післяопераційного періоду, відмічена тенденція до нормалізації  вмісту антиоксидантних ферментів редокс-системи глутатіону та показників енергетичного обміну, що свідчить про його ефективність.  Доведена ефективність і доцільність його призначення в післяопераційному періоді у дітей з ХГ та АРМ.
ПОШИРЕНІСТЬ СИНГЛНУКЛЕОТИДНОГО ПОЛІМОРФІЗМУ (SNP) RS7069102 ГЕНА SIRT1 СЕРЕД ГІПЕРТЕНЗИВНИХ МЕШКАНЦІВ ПОДІЛЬСЬКОГО РЕГІОНУ УКРАЇНИ
Authors: Старжинська Ольга , А.О. Донець
Published: October 2023

Сімейство білків сиртуїнів, зокрема, SIRT1, можуть бути важливою ланкою, яка регулює пошкодженняміокарда у пацієнтів з есенціальною гіпертензією (ЕГ), оскільки відомо, що пептид задіяний у процеси старіння серця та судин. Вивчення плазмової концентрації SIRT1, у тому числі, у зв’язку з синглнуклеотидним поліморфізмом (SNP) rs7069102 гена SIRT1, як генетичної основи для продукції пептида, може стати важливим підґрунтям для розуміння особливостей гіпертензивно обумовленого пошкодження міокарда та формування ускладнень у конкретних пацієнтів.

Тому метою дослідження було визначення поширеності та ймовірних особливостей фенотипічної реалізації SNP rs7069102 гена SIRT1, зокрема, плазмової концентрації SIRT1, у пацієнтів з ЕГ, мешканців Подільського регіону України. У ході дослідження обстежено 190 чоловіків: 70 чоловіків без серцево-судинних захворювань та 120 чоловіків з  ЕГ різної тяжкості віком від 40 до 65 років. Визначення синглнуклеотидного поліморфізму rs7069102 гена SIRT1 проводили у зразках периферичної венозної крові методом полімеразної ланцюгової реакції (ПЛР). Плазмову концентрацію SIRT1 визначали стандартизованим методом імуноферментного аналізу. Встановили, що серед мешканців Подільського регіону, Україна,  домінують носії мутантного G алеля SNP rs7069102 гена  SIRT1 як у групі контролю, так і серед хворих з ЕГ різної тяжкості, причому гомозиготи GG достовірно частіше зустрічаються серед гіпертензивних чоловіків. З носійством гомозиготного GG варіанту SNP rs7069102 гена SIRT1 асоціюється обтяжена щодо кардіоваскулярної патології спадковість та вища ймовірність виникнення ЕГ. Основним виявленим фенотипічним ефектом досліджуваного поліморфізму можна вважати достовірно нижчий плазмовий рівень SIRT1 у гомозигот GG, хворих на ЕГ, перебіг якої ускладнився ХСН.

Ключові слова: есенціальна  гіпертензія, серцева недостатність, сиртуїни,

SIRT1, (SNP) rs7069102 гена SIRT1.
Development of Ethno-STEM Learning Module based on Javanese Gamelan
Authors: Yuliana Y. , Nurwahidah I. , Widiyawati Y.
Published: October 2023

Ethno-STEM can help students to learn the right learning concepts. The purpose of the study was to design, develop, and test the feasibility of the Ethno-STEM-based science learning module for class VIII students that was feasible to use. The module was printed teaching materials. The module aimed to make students learn independently and study anywhere and anytime without the need for supporting tools. The research development module refers to the Thiagarajan 4-D (Four-D) device development model with the stages of define, design, develop, and disseminate. The samples were 12 students of class VIII in SMP Institut Indonesia in the academic year 2021- 2022. The research instruments used validation sheets of learning material experts, learning media experts, practitioners, and student questionnaires. The feasibility of the module is reviewed based on the results of analyzed data. First, the validation of the Ethno-STEM-based learning module from the science learning validator, consisting of two learning material expert lecturers, obtained an overall score of 3.0 with good criteria. Second, the expert validation of learning media, consisting of 2 media expert lecturers, obtained an overall score of 3.60 with very good criteria. Third, the practitioner validation, consisting of two junior high school science teachers, obtained an overall score of 3.88 with very good criteria. And, student responses showed a percentage score of 94.8% with a very good category. Thus, the learning module of Ethno-STEM was feasible for science learning in class VIII of junior high school.
Effect of Guided Inquiry Model by PhET Simulations Worksheet on Science Process Skills and Mastery of Concepts
Authors: Chotimah A. N. , Setyawarno D. , Rosana D.
Published: October 2023

This study aimed to (1) analyze the effect of the science learning of guided inquiry model assisted by PhET Simulations worksheet on science process skills and concept mastery on rope wave material at SMP Negeri 1 Sedayu and (2) analyze the magnitude of the effect of science learning through the guided inquiry model assisted by PhET Simulations worksheet on science process skills and concept mastery on rope waves material at SMP Negeri 1 Sedayu. This study is a quasi-experiment research with a nonequivalent pretest-posttest control group design. The population were seven classes in grade VIII at SMP Negeri 1 Sedayu. The sample were 50 students who were determined by purposive sampling technique. Data collection was observation and test techniques. Data analysis was carried out using descriptive analysis, independent sample t-test, MANOVA test, and effect size. The results showed that (1) there was a significant effect of the guided inquiry learning model assisted by the PhET Simulations worksheet on science process skills and concept mastery on rope wave material (sig. 0.000). and (2) the effect size value in the experiment class with the guided inquiry model assisted by the PhET Simulations worksheet on science process skills and concept mastery in rope wave material is relatively high (1.32 0.8).
Enlightening the Repercussion of Dark Data Management towards Malaysian SMEs Sustainability
Authors: Md Ajis Ahmad Fuzi , Md Jali Jafalizan , Ishak Isma , Harun Qamarul Nazrin
Published: October 2023

The sheer volume of dark data impacts the costs for searching and producing appropriate information and imposes a wasted storage cost in operating budgets. Therefore, a grounded theory research was conducted to investigate the dark data phenomenon towards SMEs in Malaysia. Straussian Grounded Theory Methodology was deployed to analyze collected qualitative data to investigate the repercussions of dark data management towards sustainability of Small & Medium enterprises in Malaysia. Consequently, the study found that dark data is a precious asset to leverage and maintain sustainable business, and a model on the repercussions of dark data management was proposed.
Diffusion of Innovation of E-Commerce among Service Sector SMEs in Malaysia During and Post-Pandemic Covid-19: A qualitative approach
Authors: Lempisik a.k.a Marx Mc Jeanet , Faris Niasin Mohd Adzwin
Published: October 2023

This study investigates the critical determinant for e-commerce adoption in Malaysian SMEs. It aims to see how the adoption of e-commerce influenced the food and beverages service sector in Malaysian SMEs during the COVID-19 pandemic and to find out the benefits SMEs have gained from the implementation of e-commerce in Malaysia since the outbreak of the pandemic. Theoretically, the study develops an integrated framework to better understand e-commerce adoption in SMEs. At the same time, it leads to several significant findings that provide stakeholders with insight for developing appropriate strategies and policies to enhance the diffusion of e-commerce in Malaysia.
Systematic Literature Review on Robo-Advisery Adoption towards Young People
Authors: Abdul Manaf Suhaily Maizan , Ismail Md Khairu Amin , Zakaria Shahsuzan
Published: October 2023

In the past two decades, numerous studies have focused on robo-advisers in financial technology. Robo-advisers involve automated financial advice for investors, tailoring portfolios based on risk tolerance and objectives, and automatic portfolio-monitoring and rebalancing. While robo-advisers have seen progress in adoption, there are still untapped potentials. This abstract presents a systematic literature review summarising the current state-of-the-art in robo-advisery adoption. By following a detailed, systematic literature-review methodology, the review provides valuable insights for practitioners, potential investors, and researchers seeking to identify areas for further investigation in robo-advisery adoption.
Potential Target Discovery and Drug Repurposing for Coronaviruses: Study Involving a Knowledge Graph–Based Approach
Authors: Lou Pei , Fang An , Zhao Wanqing , Yao Kuanda , Yang Yusheng , Hu Jiahui
Published: October 2023

Background

The global pandemics of severe acute respiratory syndrome, Middle East respiratory syndrome, and COVID-19 have caused unprecedented crises for public health. Coronaviruses are constantly evolving, and it is unknown which new coronavirus will emerge and when the next coronavirus will sweep across the world. Knowledge graphs are expected to help discover the pathogenicity and transmission mechanism of viruses.

Objective

The aim of this study was to discover potential targets and candidate drugs to repurpose for coronaviruses through a knowledge graph–based approach.

Methods

We propose a computational and evidence-based knowledge discovery approach to identify potential targets and candidate drugs for coronaviruses from biomedical literature and well-known knowledge bases. To organize the semantic triples extracted automatically from biomedical literature, a semantic conversion model was designed. The literature knowledge was associated and integrated with existing drug and gene knowledge through semantic mapping, and the coronavirus knowledge graph (CovKG) was constructed. We adopted both the knowledge graph embedding model and the semantic reasoning mechanism to discover unrecorded mechanisms of drug action as well as potential targets and drug candidates. Furthermore, we have provided evidence-based support with a scoring and backtracking mechanism.

Results

The constructed CovKG contains 17,369,620 triples, of which 641,195 were extracted from biomedical literature, covering 13,065 concept unique identifiers, 209 semantic types, and 97 semantic relations of the Unified Medical Language System. Through multi-source knowledge integration, 475 drugs and 262 targets were mapped to existing knowledge, and 41 new drug mechanisms of action were found by semantic reasoning, which were not recorded in the existing knowledge base. Among the knowledge graph embedding models, TransR outperformed others (mean reciprocal rank=0.2510, Hits@10=0.3505). A total of 33 potential targets and 18 drug candidates were identified for coronaviruses. Among them, 7 novel drugs (ie, quinine, nelfinavir, ivermectin, asunaprevir, tylophorine, Artemisia annua extract, and resveratrol) and 3 highly ranked targets (ie, angiotensin converting enzyme 2, transmembrane serine protease 2, and M protein) were further discussed.

Conclusions

We showed the effectiveness of a knowledge graph–based approach in potential target discovery and drug repurposing for coronaviruses. Our approach can be extended to other viruses or diseases for biomedical knowledge discovery and relevant applications.
Connect Brain, a Mobile App for Studying Depth Perception in Angiography Visualization: Gamification Study
Authors: Titov Andrey , Drouin Simon , Kersten-Oertel Marta
Published: October 2023

Background

One of the bottlenecks of visualization research is the lack of volunteers for studies that evaluate new methods and paradigms. The increased availability of web-based marketplaces, combined with the possibility of implementing volume rendering, a computationally expensive method, on mobile devices, has opened the door for using gamification in the context of medical image visualization studies.

Objective

We aimed to describe a gamified study that we conducted with the goal of comparing several cerebrovascular visualization techniques and to evaluate whether gamification is a valid paradigm for conducting user studies in the domain of medical imaging.

Methods

The study was implemented in the form of a mobile game, Connect Brain, which was developed and distributed on both Android (Google LLC) and iOS (Apple Inc) platforms. Connect Brain features 2 minigames: one asks the player to make decisions about the depth of different vessels, and the other asks the player to determine whether 2 vessels are connected.

Results

The gamification paradigm, which allowed us to collect many data samples (5267 and 1810 for the depth comparison and vessel connectivity tasks, respectively) from many participants (N=111), yielded similar results regarding the effectiveness of visualization techniques to those of smaller in-laboratory studies.

Conclusions

The results of our study suggest that the gamification paradigm not only is a viable alternative to traditional in-laboratory user studies but could also present some advantages.
Quantitative Analysis of Economic Complexity and Industrial Competitiveness of Asian Countries
Authors: Ling Huinan , Jia Zhen , Zuo Peng
Published: October 2023

This paper mainly quantifies the economic development situation and industrial competitiveness of Asian countries by measuring the Generalized Economic Complexity Index (GECI) and statistical indicators. The measurement results reveal that it can reflect the real and effective national economic industrial competitiveness more accurately than traditional macro-economic indicators promptly. Another new finding is the GECI of economies, which shows clear geographical differences, with relatively the highest in the East Asia. Besides, we compare the potential of industrial upgrading and conclude that China, Turkey and India have stronger industrial upgrading, while Qatar and Kuwait are obviously weaker.
A Study on the Current Status of Depressive Symptoms and the Application of Physical Exercise Modalities among Community-Dwelling Older Adults
Authors: Wu Yijing
Published: October 2023

As the rate of population aging continues to increase, geriatric depression, as one of the major public health problems in society, has attracted great attention. At present, the development of geriatric sports in China is insufficient, and the overall proportion of elderly people participating in physical exercise is low, especially the proportion of rural elderly people exercising is even lower than that of urban elderly people, all of which is not conducive to the play of the positive effects of physical exercise on the physical and mental health of the elderly. Adopting safe and feasible measures can bring great help to the management of depression among community-dwelling older adults. This paper analyses the current situation of depression among the elderly in community T, describes the physical exercise methods for the elderly with depression in community T, and explores the application effect of physical exercise methods for depression among the elderly in the community in combination with relevant data.
Memory and Modern Drama: Tennessee Williams’s The Glass Menagerie as a Case Study
Authors: Elmoutassim Abdelmonim
Published: October 2023

Tennessee Williams is one of the foremost playwrights in modern drama. In 1945, the American theater witnessed his mind-blowing play, The Glass Menagerie. Because of the latter, Williams received a great deal of fame and winnings. Since The Glass Menagerie is a memory play, this paper will focus on the subject of memory and its interconnectedness with modern drama first, then delve into memory theories, and lastly discuss memory mechanisms in The Glass Menagerie.
Профилактика и лечение сердечно-­сосудистых заболеваний природными антиоксидантами
Authors: Кедринская Л.И. , Яшин А.Я. , Яшин Я.И.
Published: October 2023

Многочисленные эпидемиологические, клинические и терапевтические исследования показали, что природные антиоксиданты можно эффективно использовать для профилактики и лечения сердечно-­сосудистых заболеваний, как в чистом виде, так и в составе пищевых продуктов. Сведения о применении антиоксидантов приведены в настоящем кратком обзоре. В качестве подтверждения представлена обширная, хорошо подобранная библиография (более 100 ссылок). Каждое утверждение обосновано соответствующими научными исследованиями.
Academic Burnout Profiles and Predictors of Job Seekers in their 20s
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Yang Ji-Yeon , Choi Jung Ah
Published: October 2023

Objectives This study aimed to explore whether the five profiles of job burnout identified in the research by Leiter & Maslach (2016) are also evident in academic burnout. Additionally, the study investigated the cognitive and emotional regulatory coping strategies exhibited by each profile identified in academic burnout, as well as the as-sociations with relevant variables associated with academic burnout.
Methods To this end, this study conducted latent profile analysis and multinomial logistic regression on 307 job seekers in their 20s using the R 4.2.2 program with the Maslach Burnout Inventory-student survey (MBI-SS).
Results The profiles derived from this study were found to be similar to the five optimal profiles identified in the research by Leiter & Maslach (2016). Each profile exhibited similarities to the profiles identified in Leiter & Maslach's (2016) study. Specifically, in the case of ‘Burnout,’ the profile appeared to adhere more faithfully to the concept of the profile than the research findings of Leiter & Maslach (2016). However, in the case of ‘Disengaged,’ contrary to what Leiter & Maslach (2016) claimed, it showed an increase in both cynicism and exhaustion. Regarding the validated predictors of each latent profile classification, it was found that the group with high aca-demic burnout exhibited higher levels of accommodative coping strategies and lower levels of problem-solving coping strategies in cognitive and emotional regulation strategies. Furthermore, in terms of the associations with academic-related variables, the high academic burnout group displayed lower academic self-efficacy and higher tendencies for academic procrastination, fear of failure, and lack of learning motivation compared to other groups.
Conclusions The close association between academic burnout and academic procrastination and academic self-efficacy suggests the need for future research to focus on the causal relationship between these constructs. Furthermore, theoretical and intervention implications for future strategies were discussed.
The Relationship between Early Adolescence School Violence Victimization, Peer Relationships, and the Moderating Effect of School Transfer Experience
Authors:   Korean Association For Learner-Centered Curriculum And Instruction, Shin Eunyoung
Published: October 2023

Objectives This study examines the relationship between early adolescence school violence victimization, peer relationships, and the moderating effect of school transfer experience.
Methods Using panel data from the Korean Educational Development Institute's ongoing Korean Education Longitudinal Study, which has been conducted since 2013, we conducted an analysis of school violence victim-ization experiences, peer relationships, and transfer experiences from elementary 5th grade to high school graduation. For data preprocessing and identifying transfer experiences, we utilized SPSS 27, while for examining moderation effects (multigroup analysis) using structural equation modeling, we employed Mplus 8.3.
Results Firstly, experiences of school violence during early adolescence have a negative impact on subsequent peer relationships during the adolescent period. Secondly, transfer experiences moderate the effects of school violence victimization during early adolescence on later peer relationships in adolescence.
Conclusions Experiencing school violence during early adolescence had a negative impact on the formation of peer relationships during subsequent schooling. However, it was found that when students transfered schools and joined a new peer group, they experienced less difficulty in forming peer relationships. Therefore, policy alter-natives that allow school violence victims to choose school transfers are needed.