bluuebunny/crossref_metadata_2025 huggingface dataset:
AN ERROR ANALYSIS ON STUDENTS’ TRANSLATION
Authors: Sitepu Julyanta Br , Abdulloh Abdulloh , Sarsono Sarsono
Published: September 2021

The research is conducted to find out what types of errors the students do most in translating English into Indonesian and Indonesian into English in order to improve the quality of the teaching for Private University Students. The description of the data is made by the writer based on the errors the students made in translation. The errors are articles, plural words, pronoun, noun phrases, gerund, participles, tenses, and word choices. The methodology used in this research is a qualitative research using the students’ translation from English into Indonesian and Indonesian into English. The research found the most error made by the students in translation is word choices 33.18 % or 154 errors in translating English into Indonesian and tenses 48.73% or 135 errors in translating Indonesian into English. The least error found in the students’ translation was gerund 0.64% or 3 errors in English into Indonesian and 0.72% or 2 errors Indonesian into English
Hubungan KEK dengan Anemia Gravidarum pada Ibu Riwayat BBLR
Authors: Mahmudian Arie Alfina , Dian Aby Restanty  , Sugijati Sugijati
Published: September 2021

KEK (Chronic Energy Deficiency) is a condition of the mother suffering from lack of calories and protein (malnutrition) that lasts chronic (chronic) at risk of causing complications in the mother one of which is anemia gravidarum. Anemia in pregnancy is a decrease in Hb levels, so that the carrying capacity of oxygen for the needs of vital organs in the mother and fetus is reduced. The purpose of this study is to determine the relationship of KEK with anemia gravidarum in mothers with low birth weigth history. The correlation analytic research design is a case control study approach, the population is 68 mothers with low birth weight history, using simple random sampling technique, the sample is calculated using Slovin formula, the number of 58 low birth weight history mothers fulfills the inclusion criteria. The research instrument used observation sheets to look at secondary data on cohorts of pregnant women, data analysis using the chi square test obtained a p value of 0, 001 means that p <0.05 indicates the relationship of KEK with anemia gravidarum in women with low birth weight history with a close relationship is sufficient. The value of the Contingency Coefficient in the Chronic Energy Deficiency variable is 0.39, which means that the relationship between KEK and anemia gravidarum is sufficient. The Odds Ratio (OR) value in the Chronic Energy Deficiency variable is 6.9, which means that pregnant women with nutritional status of Chronic Energy Deficiency have a 6.9 times greater risk of anemia during pregnancy than those who are not. Inadequate nutritional needs have a greater risk of anemia during pregnancy and the risk of giving birth to Low Birth Weight Babies. Researchers suggest providing counseling to women of adolescence, women of childbearing age and especially pregnant women so that they can add more information about the importance of nutritional status in pregnant women, the dangers of anemia during pregnancy and also the importance of consuming blood booster tablets during pregnancy. So that it is expected to reduce the incidence of anemia pregnant women case and low birth weight history.
Hubungan Karakteristik Gambaran Radiografi Toraks Distribusi Lesi Paru dengan Prognosis Pasien COVID-19
Authors: Sinaga Fransisca Tarida Yuniar , Rusmini Hetti , Wahyudi Alfi , Soemarwoto Retno Ariza Soeprihatini , Messah Anse Diana Valentine , Putri Intan Utami
Published: September 2021

Coronavirus Disease 2019 (COVID-19) is an infectious disease caused by Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2). The transmission rapidly from human to human via aerosol droplets and direct contact, accelerating the spread of SARS-CoV-2 in various parts of the world. Chest radiograph can be used to monitor the development of pulmonary disorders due to COVID-19, a reference for medical personnel in screening for patients who are suspected of being infected to COVID-19, and to study the prognosis of patients COVID-19 as well. The aims of this study was to determine the relationship between the characteristics of the distribution of chest radiograph lesions and the prognosis of COVID-19 patients in Bandar Lampung City in 2020. This study was a descriptive analytic study with a retrospective approach. Analysis of the data used are univariate analysis and bivariate analysis using the Spearman correlation test. The results of statistical tests using the Spearman Correlation Test showed that there was a relationship between the characteristics of the distribution of chest radiograph lesions and the prognosis of patients who were confirmed positive for COVID-19 in Bandar Lampung City in 2020, p-value = 0.001 (r = 0.203 weak relationship) on the chest radiograph features of involvement lung, p-value = 0.002 (r = 0.188 weak relationship) on the chest radiograph distribution of lesions from top to bottom, and p-value = 0.030 (r = 0.135 weak relationship) on the chest radiograph distribution of central to peripheral lesions. The conclusion of this study is that there is a significant relationship between the characteristics of the distribution of chest radiograph lesions and the prognosis of COVID-19 patients in Bandar Lampung City in 2020.
Hubungan Antara Komitmen Organisasi Dan Kepuasan Kerja Dengan Organizational Citizenship Behavior (OCB) Pada Perawat di Rumah Sakit Umum Wisma Rini Pringsewu
Authors: Supriyati Supriyati , Lutfianawati Dewi , Setiawati Octa Reni , Putri Andini alfira
Published: September 2021

In the hospital industry, the performance of nurses is very important in the success in the hospital. It is necessary for the workforce to be able to work optimally and the role of Organizational Citizenship Behavior (OCB). OCB is a behavior of an employee that is not formally regulated and can improve the performance of the organization. Some of the factors that affect OCB are organizational commitment and job satisfaction. Therefore, this study aims to find out the relationship of organizational commitment and job satisfaction with OCB. Data collection in this study used OCB scale, organizational commitment, and job satisfaction. Sampling using total sampling, with a sample number of 100 nurses at the public hospital Wisma Rini Pringsewu.  Data analysis using multiple linear regression analysis with the help of SPSS 22.0 for windows. The results showed that Deviation From Linearity between OCB and Organizational Commitment of 0.707 and between OCB and Job Satisfaction of 0.602, where the value of each variable is p>0.05s so that it indicates there is a linear relationship, and can be continued with hypothetical tests. It is known that the first hypothesis is that the relationship between organizational commitment and job satisfaction is positively correlated with ocb variables with the significance of p<0.01 and p<0.05 received. The conclusion is that there is a relationship between organizational commitment and job satisfaction with Organizational Citizenship Behavior (OCB)
Predicting Behavioral Intention: The Mechanism from Pretrip to Posttrip
Authors: Huang Shuyue , Choi Hwansuk Chris , Shen Ye , Chang Howook (Sean)
Published: September 2021

Despite research on predicting tourist behavioral intention, the existing research lacks a holistic understanding of the interrelationships among the determinants (i.e., a continuous mechanism from pretrip to posttrip). This article develops an integrated model to test the effects of motivation (pretrip), tourist activity participation and perceived value (on-site), and satisfaction (posttrip) on behavioral intention to help explain this mechanism. This article first establishes a five-factor structure of motivation and then examines the causal relationships among research constructs using structural equation modeling (SEM). Results show that motivation directly and significantly affects all other constructs and has strong total effects on satisfaction and behavioral intention. Tourist activity participation predicts satisfaction but not the behavioral intention. The relationships among perceived value, satisfaction, and behavioral intention are consistent with the literature. Regarding the total effects on behavioral intention, satisfaction is the strongest predictor, followed by perceived value and motivation. Also, this study is among only a few attempts to explore the Canadian domestic tourism market and provides marketing insights into destination marketing organizations (DMOs).
DETERMINAN KETEPATAN WAKTU PELAPORAN KEUANGAN
Authors: Yulianti Vista
Published: September 2021

Penelitian ini bertujuan untuk menemukan bukti empiris tentang faktor-faktor yang mempengaruhi ketepatan waktu pelaporan keuangan pada perusahaan Transportasi yang terdaftar di BEI. Faktor-faktor yang diuji dalam penelitian ini yaitu umur perusahaan, struktur kepemilikan, dan kualitas auditor. Periode penelitian yang digunakan adalah 3 tahun yaitu 2016-2018. Penelitian ini dilakukan dengan menggunakan data sekunder. Teknik sampel yang digunakan adalah purposive sampling. dari 35 perusahaan Transportasi hanya diambil 22 perusahaan, karena memiliki laporan keuangan secara lengkap. Metode analisis yang digunakan adalah analisis regresi logistic. Dengan menggunakan analisa regresi, maka dapat diketahui bahwa umur perusahaan, struktur kepemilikan, dan kualitas auditor tidak berpengaruh signifikan terhadap ketepatan waktu pelaporan keuangan. Dari penelitian yang dilakukan, maka diperoleh kesimpulan bahwa umur perusahaan, struktur kepemilikan, dan kualitas auditor tidak berpengaruh signifikan terhadap ketepatan waktu pelaporan keuangan.
PENGARUH LABA AKUNTANSI DAN ARUS KAS OPERASI TERHADAP HARGA SAHAM
Authors: Asiah Neng , Mulyani Yeni
Published: September 2021

Penelitian ini bertujuan untuk mengetahui Pengaruh Laba Akuntansi dan Arus Kas Operasi terhadap Harga Saham pada perusahaan Aneka Industri yang terdaftar di bursa efek indonesia (BEI) tahun 2015-2017. Metode yang digunakan dalam penelitian ini adalah metode kuantitatif. Teknik pengambilan sampel yang digunakan adalah purposive sampling dengan cara pengambilan sample menggunakan kriteria tertentu. Data sekunder yang diambil untuk penelitian ini berupa data akuntansi laporan keuangan perusahaan Aneka Industri di bursa efek indonesia (BEI) tahun 2015-2017. Penelitian ini menggunakan beberapa pengujian, diantaranya pengujian secara parsial (Uji t), pengujian secara simultan (Uji F) dan analisis regresi linier berganda. Hasil penelitian menggunakan uji parsial (t) menunjukan bahwa Laba Akuntansi (X1) tidak berpengaruh terhadap Harga saham (Y) sedangkan Arus Kas Operasi (X2) berpengaruh terhadap harga saham (Y). Sedangkan dengan (Uji F) Variabel Laba Akuntansi dan Arus Kas Operasi secara bersama-sama tidak berpengaruh terhadap Harga saham (Y) pada perusahaan Aneka Industri di bursa efek indonesia (BEI) tahun 2015-2017.
PENGARUH RASIO KEUANGAN TERHADAP PERUBAHAN LABA
Authors: Widati Sindik , Yuliandri Rita
Published: September 2021

Penelitian ini bertujuan untuk menguji dan menganalisis pengaruh Current Ratio (CR),Debt to Asset Ratio (DAR), Total Assets Turnover (TATO), Net Pofit Margin (NPM) secara simultan aupun parsial terhadap perubahan laba pada perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2015-2019. Metode analisis data yang digunakan dalam penelitian ini adalah menggunkan metode regresi linier berganda. Sampel yang digunakan dalam penelitian adalah perusahaan manufaktur yang terdaftar di Bursa Efek Indonesia periode 2015-2019, mepublikasikan laporan keuangan secara berkala, dan dalam laporan keuangannya melaporkan laba. Berdasarkan kriteria tersebut, sampel yang digunakan dalam penelitian ini adalah 6 perusahaan otomotif. Hasil dari penelitian ini menunjukkan bahwa variabel CR, DAR,dan NPM tidak berpengaruh terhadap perubahan laba. Sedangkan TATO berpengaruh terhadap perubahan laba.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI AUDIT DELAY
Authors: Permatasari Maulina Dyah , Saputra Muhammad Mahessa
Published: September 2021

Setiap perusahaan yang tercatat di Bursa Efek Indonesia harus melaporkan laporan keuangannya kepada Otoritas Jasa Keuangan (OJK) setelah diaudit oleh auditor eksternal. Jika terlambat, maka akan dikenakan sanksi. Audit delay adalah lamanya waktu untuk menyelesaikan proses audit dari akhir tahun fiskal hingga tanggal diterbitkannya laporan audit. Tujuan penelitian ini adalah untuk mengetahui pengaruh pergantian auditor, reputasi KAP, opini audit dan komite audit terhadap audit delay pada perusahaan jasa transportasi yang terdaftar di Bursa Efek Indonesia tahun 2016-2019. Populasi penelitian ini adalah perusahaan jasa transportasi yang terdaftar di BEI tahun 2016–2019 sebanyak 45 perusahaan dengan teknik pengambilan sampel yaitu puposive sampling dan menghasilkan 27 perusahaan untuk diuji. Teknik analisis yang digunakan adalah analisis logistik. Hasil penelitian menunjukkan bahwa (1) pergantian auditor tidak berpengaruh terhadap audit delay dengan nilai β 0,089 dan nilai signifikansinya 0,875, (2) reputasi auditor tidak berpengaruh terhadap audit delay dengan nilai β -0,512 dan nilai signifikansinya 0,420, (3) opini audit berpengaruh negatif signifikan terhadap audit delay dengan nilai β -1.992 dan nilai signifikansinya 0,004, (4) komite audit tidak berpengaruh terhadap audit delay dengan nilai β 0,098 dan nilai signifikansinya 0,776, (5) Hasil uji simultan pada analisis ini menggunakan Omnibus Test yang menunjukkan bahwa semua variabel secara simultan berpengaruh signifikan terhadap audit delay dengan nilai signifikansinya 0,046.
PENGARUH GOOD CORPORATE GOVERNANCE DAN KINERJA KEUANGAN TERHADAP NILAI PERUSAHAAN
Authors: Hidayat Taufik , Triwibowo Edi , Vebrina Marpaung Novel
Published: September 2021

Penelitian ini bertujuan untuk menganalisis pengaruh good corporate governance dan kinerja keuangan terhadap nilai perusahaan yang dapat dijadikan acuan manajemen dalam menggunakan tata kelola yang baik dan tepat sehingga dapat menguntungkan perusahaan secara keseluruhan. Populasi pada penelitian ini menggunakan seluruh perusahaan yang terdaftar di Bursa Efek Indonesia dengan sampel perusahaan BUMN pada tahun 2016-2019. Variabel yang digunakan dalam penelitian ini yaitu dewan komisaris independen, kepemilikan institusional, komite audit dan Return on Equity (ROE), sedangkan variabel nilai perusahaan diproksikan dengan Price Book Value (PBV). Teknik yang digunakan dalam pengambilan sampel dalam penelitian ini adalah dengan menggunakan teknik purposive sampling. Jenis penelitian yang yang digunakan adalah penelitian penjelasan dengan pendekatan kuantitatif. Berdasarkan analisis diperoleh hasil bahwa secara parsial, dewan komisaris independen dan ROE berpengaruh positif dan signifikan terhadap nilai perusahaan, kepemilikan institusional berpengaruh negatif dan signifikan terhadap nilai perusahaan, komite audit tidak berpengaruh dan tidak signifikan terhadap nilai perusahaan, Secara simultan dewan komisaris independen, kepemilikan institusional, komite audit dan ROE berpengaruh terhadap nilai perusahaan.
ANALISIS FAKTOR-FAKTOR YANG MEMPENGARUHI KEENGGANAN MENABUNG DI BANK SYARIAH
Authors: Achmad Listian , Purwanti Dewi
Published: September 2021

Penelitian ini bertujuan untuk mengetahui faktor-faktor utama yang mempengaruhi keengganan masyarakat cikarang selatan untuk menabung di bank syariah. Hasil penelitian menunjukkan bahwa faktor-faktor yang mempengaruhi keengganan  masyarakat dalam menabung di Bank Syariah di kecamatan Cikarang Selatan yaitu: faktor performa; faktor produk; faktor pelayanan; dan faktor pemasaran. Hasil penelitian tersebut berdasarkan hasil olah data dari tujuh desa yang ada di kecamatan Cikarang Selatan.
PENGARUH TINGKAT PEMAHAMAN DAN KESADARAN MUZAKKI DALAM MEMBAYAR ZAKAT (STUDI KASUS UNIVERSITAS PELITA BANGSA)
Authors: Ali Ali Nur Ahmad , Susanto Hadi
Published: September 2021

This study aims to determine Muzakki's level of understanding and awareness in paying zakat. find out the potential of zakat in the Pelita Bangsa academic community, because based on the author's field observations, the author suspects that the Pelita Bangsa academic community consists of lecturers, employees, and students who earn quite a lot. In this study, using the type of field research (field research) with a quantitative approach through distributing questionnaires and questionnaires that have been distributed directly to respondents. Research on the level of understanding and awareness of muzakki in paying zakat. The population used in this study is the academic community consisting of lecturers, students, and employees, who play a role in the implementation of zakat in Pelita Bangsa University. The population that will be the object of research is 100 respondents.

Based on the results of research data analysis and calculations that have been carried out by researchers, it can be concluded that there is a significant influence between the level of understanding on muzakki paying zakat. With a coefficient value of 0.727 when compared with the value of rtable at a significant level of 5% of 0.197 then rcount > rtable (0.727> 0.197) so that the coefficient value is significant, there is also a significant influence between the level of awareness of muzakki paying zakat. With a coefficient value of 0.657 when compared with the value of rtable at a significant level of 5% of 0.197, then rcount > rtable (0.657> 0.197) so that the coefficient value is significant, and the results of the analysis conducted by researchers obtained a value of fcount of 54.952. When compared with the value of the fable with a significance level of 5% of 3.09. Then fcount > ftable (54,952> 3.09) so that this value can be said to be significant. This means that the level of understanding and awareness simultaneously influences muzakki to pay zakat.
PERANAN BAITUL MAAL WAT TAMWIL DALAM MENINGKATKAN USAHA MIKRO MELALUI PEMBIAYAAN MUDHARABAH (Studi Kasus BMT Fajar Cabang Cileungsi Bogor Periode 2018-2019)
Authors: Sarwo Sarwo Edy , Rayuningsih
Published: September 2021

This research is motivated by the presence of Islamic Microfinance Institutions in the form of BMT, namely BMT Fajar in the community, especially the people of Cileungsi-Bogor, is expected to bring changes in various aspects of people's lives. In the case of the people of Cileungsi Village, Bogor Regency, where the community is not familiar with Sharia Microfinance Institutions such as BMTs well. Until finally people prefer to make loans to Mobile Banks or so-called loan sharks with interest that are not small as business financing capital, it is the habit of borrowing capital to loan sharks that is the problem and attracts the author's interest to do research.

This study aims to determine the background of BMT Fajar in providing mudharabah financing, to know the mudharabah financing procedure, and to determine the role of mudharabah financing in BMT Fajar. The methodology used in this study used a qualitative approach, namely field research and library research. Field research is data collection techniques using observation, interview and documentation methods with Branch Heads, BMT Fajar Cileungsi-Bogor UMKM entrepreneurs, and their business customers. So as to get accurate data on the research process, and library research data, namely by means of data analysis using inductive, deductive and comparative.

Through interviews and observations, it can be seen that based on the results of the research it can be concluded that the role of BMT Fajar's Cileungsi branch in improving micro-businesses is by BMT Fajar to provide financing products that are not difficult in terms of capital, which do not apply the usury system in the operational system, but are replaced with a profit sharing system. between BMT and members in accordance with Islamic Sharia. One of them is through Mudharabah financing. Because they saw many Little Pengusa who had gone out of business. Whereas Small and Medium Enterprises have the potential for development in facing the Economic Crisis.
ANALISIS UANG MUKA DALAM AKAD MURABAHAH PADA KREDIT PEMILIKAN RUMAH (Studi Pada BNI Syariah KCP JABABEKA Cikarang Bekasi)
Authors: Ahmad Listian , Sulistiana Tri
Published: September 2021

According to the Classical Islamic Literatures, down payment is clearly known as Urban in Arabic, or in Bahasa accepted by Panjar, which means an initial agreed contract into a transaction. Islamic Scholars arguably have different opinions in implementing down payment as a method in the transaction. There are some scholars who do not agree to put down payment as a particular way in the transaction, but others do. However, by exercising the quality of specific reasoning that is applied, and also the fact of the acceptance of the system of transaction, therefore this method of payment is generally accepted.

The first objective of this study is to determine the down payment mechanism and implementation of KPR financing with a murabahah contract at BNI Syariah KCP JABABEKA Cikarang Bekasi which is contained in the Griya iB Hasanah product. Second, to find out the settlement steps in case of problematic or bad financing. The three views of Islamic law in the perspective of muamalah fiqh towards down payments in a murabahah contract on a KPR at BNI Syariah KCP JABABEKA Cikarang Bekasi. This type of research is qualitative research. The data used are primary and secondary data. Primary and secondary data were obtained from observations, interviews, documentation, field studies, and from existing literature.

The results of this study are advances in murabahah contracts on KPR in BNI Syariah which refer to the DSN-MUI Fatwa Number 13 of 2000 concerning advances in murabahah. It seems that the fatwa is influenced by the thoughts / opinions of Imam Ahmad and his followers who allow buying and selling transactions using advances, then referring to the existing regulations of the OJK, the regulator of BI, that every financing, both conventional and sharia, must have an advance.
ANALISIS STRATEGI MARKETING LAYANAN PAYROLL (Studi Kasus Bank BNI Syariah KCP Jababeka-Cikarang)
Authors: Ardianto Riski , Achmad Listian , Kurniawati Ria
Published: September 2021

In recent years, Islamic banking has experienced positive developments. With a situation like this, conventional banking will face new competition with the presence of Islamic banks. The competition is in its products, one of which is a payroll service product that can help a companies or institutes pay its employees en masse and efficiently at one time. At this time not only conventional banks have payroll service products, Islamic banks also have payroll service products that can meet the needs of companies or institutes in managing finances whose operating processes are adjusted to Islamic sharia principles. 

 This study aims to determine the marketing strategies implemented in BNI Syariah, know the concept of the system of marketing payroll service product in BNI Syariah KCP Jababeka-Cikarang and find out obstacles faced by BNI Syariah in implementing the marketing the market strategy of its products. This study uses a qualitative approach, namely field research and library research. Field research, namely data collection techniques with the method of observation, interviews and documentation with marketing staff and customers of BNI Syariah KCP Jababeka-Cikarang so as to get accurate data in the research process. And library research, namely data collection techniques using written sources.

Through interviews and observation it can be seen that the marketing strategy carried out by BNI Syariah KCP Jababeka-Cikarang in marketing their Payroll Service products is by using the Marketing Mix 7P (Product, Price, Place, Promotion, People, Process, Physical Evidance), and the concepts applied in its marketing in the form of needs, wants, demands, products, value, costs, satisfaction, exchange and markets. And the type of payroll system used is BNIDirect which is one of a number of financial management service provided by BNI Syariah KCP Jababeka-Cikarang.
ANALISIS STRATEGI FUNDRAISING ZAKAT DALAM MENINGKATKAN JUMLAH MUZAKKI Studi pada LAZ BaitulMaalKu Kabupaten Karawang
Authors: Nugroho Arief , Ahmad Ali , Wijoyo Wirjo
Published: September 2021

The zakat fundraising strategy is an effort to collect zakat from individuals or business entities to achieve zakat goals. The main source of zakat fundraising is muzakki. So considering that the zakat fundraising process is fundamental to zakat management efforts, parties who have been given the authority to manage zakat must be able to convince the Muslim community about the importance of zakat. The fundraising strategy that has been implemented has not been able to achieve zakat potential and zakat fundraising targets in Karawang Regency. And the offline fundraising strategy has not been optimal in increasing the amount of funds and the number of muzakki in Karawang Regency. And this research is how the constraints in the fundraising strategy at LAZ BaitulMaalKu, Karawang Regency.

This research uses qualitative methods, data collection with 3 methods, namely: observation, interviews, and documentation. After the data is collected, the next step, with the analysis stages, namely, data reduction, data presentation and drawing conclusions. The results of the research carried out are zakat fundraising strategies in increasing the number of muzakki at LAZ BaitulMaalKu, namely using 2 (two) strategies, the first is Direct Strategy (Offline) such as fundraising campaign, zakat pick-up services, and fundraising retail, namely the socialization and education of zakat to majelis taklim and companies. company. Second, the strategy is indirect (online) or indirectly, including through good friends channels, social media, through zakat accounts, and payroll or partnerships with corporations in Karawang. The strategy that is considered the most effective is the indirect strategy (online), namely payroll through the transfer of a partnership cooperation account with a corporation in Karawang.

For factors driving the zakat fundraising strategy in increasing the number of muzakki at LAZ BaitulMaalKu, namely Institutional Legality, Monthly Compensation for the Elderly, Mustahiq empowerment programs, scholarships for dhuafa/outstanding students, and other programs that can make muzakki interested fulfill it in BaitulMaalku. While the inhibiting factor for the zakat fundraising strategy at LAZ BaitulMaalKu, namely knowledge about zakat in some communities is still lacking, some people believe more in religious figures and there are also people who channel directly, the Amil Zakat Institution is flourishing in the midst of society despite the legality of the institution. No, and the Islamic philanthropic institute LAZNAS is conducting fundraising in Karawang Regency.
Experimental models in the study of pathogenesis and the development of treatments for ovarian cancer (systematic review)
Authors: ZHUKOVA Galina , Verenikina Ekasterina , Protasova Tatiana , Yakubova Daria , Volkova Anastasia
Published: September 2021

A systematic review of modern methods of experimental study of ovarian cancer using traditional (immunocompetent, genetically engineered and immunodeficient) and non-traditional (that don’t belong to the mammals) animal models,established and primary cultures of human ovarian cancer, including three-dimensional organotypic spheroids (3D- models ex vivo) is presented. The prospects of the considered models for studying of the pathogenesis of various molecular-genetic and histological variants of ovarian cancer, as well as for developing methods of personalized treatment, are discussed. The limitations of modern animal models are indicated. The greatest attention is paid to studies on immunodeficient animals using xenografts based on established cultures of human ovarian cancer cells and on tumor tissue obtained directly from the patients (patient derived xenografts, PDX). The questions of various variants of xenograft transplantation with an emphasis on the problems of orthotopic transplantation of human ovarian cancer into immunodeficient mice and the relevance of methods for local humanization in heterotopic transplantation are considered. The most promising, from the point of the author’s view, approaches to studying the effectiveness of drug therapy for ovarian cancer in immunodeficient animal models are outlined. To prepare a systematic review, a literature search was carried out on the Scopus, Web of Science, Med Line, PubMed, Cyber Leninka, RSCI databases. The analysis used literature sources indexed in the Scopus and Web of Science databases (97%) and the RSCI. More than 60% of the works amount has been published over the past 5 years.
The effect of certain autophagy proteins (LC3b and Beclin) and apotosis (Casp8 and Bcl-2) on the clinical course of ovarian cancer
Authors: Gafiullina Aliia , Afanaseva Zinaida , Garipov Karim , Abramova Zinaida
Published: September 2021

Treatment of ovarian cancer remains an important problem in practical oncology due to the increase in morbidity and mortality from this disease.
The aim is to summarize the available literature data on the molecular mechanisms of the participation of various proteins of autophagy and apoptosis in the development, progression, formation of chemoresistance and in the assessment of the prognosis of epithelial ovarian cancer.
Materials and methods. The search for information was carried out in the materials of the databases Medline, Cochrane Library, Elibrary, NCBI, RSCI, instructions for the medical use of drugs, using keywords in the title. Used 39 articles to write this systematic review.
Results. The review examines the molecular mechanisms of autophagy and apoptosis involved in the progression of ovarian cancer and in the formation of resistance to anticancer drug therapy. It has been shown that modulation of autophagy and apoptosis can change the effectiveness of drug treatment for this tumor.
Conclusion. Considering the literature data on the ambiguous role of autophagy and apoptosis in the course of ovarian cancer and the formation of resistance to antitumor treatment, further study is required and the search for new molecular targets for their modulation is required.
The role of autophagy and vesicular trafficking in melanoma development
Authors: Taskaeva Iuliia , Shatruk Anastasia , Bgatova Nataliya
Published: September 2021

The role of autophagy and vesicular trafficking in carcinogenesis, including melanoma, is ambiguous: on the one hand, they contribute to the maintenance of intracellular homeostasis and the tumor progression, on the other hand, they can initiate cancer cell death. These processes have a significant impact on the metabolism of melanoma cells and could be associated with metastasis, tumor growth and progression. The review examines the mechanisms of autophagy and vesicular trafficking and presents the modern literature data demonstrating the role of the intracellular transport system in oncogenesis and melanoma development. A literature search was performed in the PubMed database.
The state of cancer care in Russia: lung cancer, patient survival (population study at the federal district level)
Authors: Merabishvili Vakhtang , Iurkova Iuliia , Levchenko Evgenii , Shcherbakov Aleksandr , Krotov Nikolai
Published: September 2021

Lung cancer (LC) remains the main cause of morbidity and mortality in many economically developed countries of the world. In 2019, more than 60 thousand primary cases of LC and more than 50 thousand deaths from this cause were recorded in Russia. The registration reliability index remains high - 0.83, which indicates a significant underestimation of primary patients.At the same time, it should be noted that the standardized rates of morbidity and mortality from LC continue to decline. The most effective criterion for evaluating the activity of the oncological service is the indicator of the observed and relative survival of patients with malignant neoplasms (MNO). Such a possibility exists in many territories of Russia, but it is calculated only in selected territories working according to our programs, and first of all, in the newly created population cancer register of the Northwestern Federal District (NWFD) with a database (DB) of more than 1 million. 350 thousand observations.The results obtained can be fully extended to the whole of Russia, since the levels of standardized indicators of morbidity and mortality from LC in Russia and the NWFD of the Russian Federation are practically identical.The study showed that from 2000 to 2017, the median survival rate of patients with LC in the NWFD increased from 6.4 to 8.0 months, and the one-year mortality rate decreased from 65,2% to 60,8%.The change in indicators is extremely slow. Differences in the mortality rate (in standardized indicators) from LC between men and women differ in Russia by 7,1, in the NWFD of the RF - by 7.0.Mortality in men from LC in the first year of observation is 63.5% versus 52.5% among the female population, which is primarily due to the peculiarities of the industrial production process and bad habits that are more characteristic of the male population.
Survival among cancers screened at the first stage of Dispanserization of certain groups of the adult population: a population-based epidemiological analysis
Authors: Valkova Ludmila , Merabishvili Vakhtang , Pankratyeva Aleksandra , Agaeva Anna , Ryzhov Anton , Potekhina Elena , Shcherbakov Alexander , Dyachenko Andrey , Voroshilov Yury , Valkov Mikhail
Published: September 2021

Objective: to evaluate trends of survival in nine index malignant neoplasms (iMNs), which are screened at the first stage of the Dispanserization of certain groups of the adult population (DCGAP), on data of the Arkhangelsk regional cancer registry over a period 2006-2019.

Materials and methods. We compared two seven-year periods 2006-2012 and 2013-2019, before and after the introduction of the DCGAP. The 1- and 5-year cancer-specific survival (CSS) rate was calculated using the life table and Kaplan-Meier methods with an assessment of the differences by log-rank. Cox regression analysis with sequential input was used to identify possible causes of differences in survival between periods and independent prognostic factors.

Results. 37197 cases were selected for analysis. 5-year CSS estimates in 2013-2019 compared with the previous seven-year period significantly increased for all nine iMNs, by from 2.5% [2006-2012, 12.5% ​​(95% confidence interval (CI) 11.4-13.6%) vs 2013-2019, 15.0 (95% CI 13.7-16.5%)] in lung cancer up to 12.6% [2006-2012, 31.0% (95% CI 28.6-33.4%) vs 2013-2019, 43.6 (95% CI 40.8-46.2%)]. Correction for the stage (possible effect of screening) in the Cox model has led to a decrease in the hazard ratio (HR) of death from cancer of the colon, rectum, breast, kidney by 38-64%, no change for other iMNs; while for cervical cancer, it has increased. Adjustment for the variable "treatment method" led to a 34-100% decrease in the HR in the Cox model for all iMNs, except for prostate cancer.

Conclusion. The increase in survival estimates for nine iMNs in 2013-2019 can be explained to a large extent by improved access to cancer-directed treatment and its quality; the contribution of DCGAP is possible in renal, breast and colorectal cancer.

Key words: malignant neoplasms, screening, dispensarization of certain groups of the adult population, survival
Radiomodifiers in the combined treatment of rectal cancer patients
Authors: Barsukov Yury , Tkachev Sergey , Mammadli Zaman , Aliev Vyacheslav , Vlasov Oleg , Oltarzhevskaya Natalia , Korovina Maria
Published: September 2021

Objective. To evaluate the effectiveness of the combined method of treatment of patients with rectal cancer using several variants of polyradiomodification (CT+PRM).
Material and methods. To increase the effectiveness of the «short» course of neoadjuvant radiation therapy (RT) 5×5 Gy until total focal dose Gy, the concept of polyradiomodification proposed by S. P. Yarmonenko (1982) was used [1]. Three radiomodifiers were used: local intracavitary microwave hyperthermia (MWH), Metronidazole (MZ) as part of a polymer composition for intrarectal administration, and the chemotherapy drug Capecitabine (Cap).
Four variants of the PRM have been created, divided into two-component and three-component. Two-component variants were used when the MWH was not possible in the case of stenosis or localization of cancer in the upper ampullary rectum. Initially, Capecitabine was used at a daily dose of 1.5 g/m2 on 1–5 days in combination with a double administration of Metronidazole («Cap5+MZ») and surgery 3 weeks after RT, and later the dose of Capecitabine was increased to 2.0 g/m2 on 1–14 days («Cap14+MZ») with surgery 4–6 weeks after RT. With three-component versions of PRM, 3 additional sessions of MWH were used: «Cap5+MZ+MWH» and «Cap14+MZ+MWH». A total of 241 patients were included in the study.
Results. The total toxicity in CT+PRM was 33.4%, and the overall rate of postoperative complications was 14.9%. The 5-year relapse-free survival (RFS) rate of 80.5% was achieved due to pronounced local control: cancer recurrence was detected only in 1 (0.4%) of 241 patients. This made it possible to perform sphincter-sparing operations (SSO) without compromising oncological results in 211 (86.7%) patients out of 241. The most pronounced therapeutic pathomorphosis in the tumor was achieved with «Cap14+MZ» and «Cap14+MZ+MWH»: pathomorphosis of the III degree was achieved in 9 (30.0%) of 30 patients with «Cap14+MZ», and in 13 (25.0%) of 52 patients with «Cap14+MZ+MWH», a complete pathomorphological response was detected in 7 (23.4%) of 30 patients with «Cap14+MZ», and in 9 (17.3%) of 52 patients with «Cap14+MZ+MWH». When reaching the III–IV degree of pathomorphosis, distant metastases were detected in 6.3% of patients, at the II degree and below — in 19.7% (p=0.01).
Conclusion. When using CT+PRM, 5-year RFS rate was increased to 80.5%, and the frequency of SSO was increased to 86.7%, with a low level of postoperative complications (14.9%) and acceptable toxicity (33.4%).
Surgical treatment of recurrent borderline serous ovarian tumor
Authors: Davydova Irina , Karseladze Apollon , Kuznetsov Viktor , Meshcheriakova Liudmila
Published: September 2021

Recurrences of serous borderline tumors (PCOS) are quite rare and, as a result, have not been sufficiently studied and presented in the literature. Despite the obvious relative «benignity» of borderline tumors, the course and prognosis of recurrent PCOS may be unfavorable. The article describes the reasons influencing the development of recurrence of PCOS, presents various options for recurrence of PCOS, methods of their treatment. This publication highlights the factors influencing the effectiveness of treatment, survival and prognosis of the disease. The article is illustrated with a rare clinical observation of multiple recurrence of PCOS with a favorable outcome.
Land Ownership of Territorial Communities
Authors: HRYNKO Svitlana , KOSTIASHKIN Ivan
Published: September 2021

Taking into account the ongoing democratic transformations in our country, the decentralization reform deserves special attention, which is aimed at ensuring broad independence of territorial communities in solving their own socio-economic problems of a particular region. One of the key issues of such a reform is the formation of capable administrative-territorial units, endowed with full power not only in terms of administrative management but as full owners of the relevant resource base grounded on land. Unfortunately, the transformations carried out in Ukraine through privatization in general and privatization of land and legislative consolidation of new forms of land ownership have led to uncertainty about the object composition of communal land ownership, failed to ensure social harmony, creating crisis phenomena of demographic and socio-economic nature, especially in rural areas. As a result, the legal model of state regulation of land relations remains incomplete, in which the balance of private and public interests in land use within territorial communities would be ensured by law, which determined the content of the study. The work analyses the theoretical and normative principles of land ownership, in particular, the conclusion that the form of land ownership due to its functional purpose and special subject-object composition, determines the mechanism of formation and termination of ownership. Scientific conclusions and recommendations are formulated, on which it is expedient to build a modern state policy on the formation and establishment in society of the concept of communal ownership of land as a basis for the effective development of territorial communities. According to the results of the study, the need to change the administrative-territorial division by regulating the community at the constitutional level as the primary administrative-territorial unit, which is the basis for the formation of communal land ownership. Amendments to the Land Code of Ukraine are proposed in order to determine the right of communal ownership of land within territorial communities.
Place of the Development Agreement among the Contracts in the Construction Industry
Authors: BLIAKHARSKYІ Yaroslav
Published: September 2021

The article is devoted to the implementation of the comparative characteristics of the development agreement and other similar contractual structures that can be used by businesses in the field of construction. The author provides the author’s definition of the development agreement and draws attention to the fact that none of the agreements named in the current legislation of Ukraine fully reflects the specifics of the development relationship. At the same time, the development agreement in its content contains features (elements) characteristic of a number of other agreements, in particular, agency, concession, joint venture, simple partnership, property management, power of attorney, commission, contract, etc. In the article it is concluded that in the scientific literature, the development agreement is often disclosed through the construction of the agency agreement. However, such a position, according to the author, is unfounded, which is proved by a distinguishing number of common and distinctive features of these agreements. The situation is similar with power of attorney and commission agreements, the legal constructions of which can only partially satisfy the needs of the customer and the developer in settling relations between them. The author argues that the development agreement should also be distinguished from a rather similar in content concession agreement, the legal regulation of which is provided by the Law of Ukraine «On Concession» № 155-IX of 03.10.2019. In particular, the differences are in the subject, the procedure for concluding and executing agreements, the mandatory presence of a public law element in the concession agreement and a number of other aspects. In the article it is emphasized that the development agreement also cannot be reduced to the construction of a joint venture agreement, a simple partnership agreement and a property management agreement. However, some features (elements) of the latter may be given in the development agreement. The author emphasizes that the development agreement should be distinguished from agreements in the field of construction, primarily in their subject, which determines the presence of a number of other distinctive features. Thus, the development agreement does not provide for the direct performance of construction work by the developer, in contrast to agreements. In turn, the latter do not provide for the provision of services to the customer, which are the subject of the development agreement.
Informational and Communication Technologies Used in the Doctors of Philosophy Preparation in the Conditions of Distance Education
Authors: FEDORCHUK Olha
Published: September 2021

The paper is dedicated to issues of distance education of applicants for scientific degrees — graduate students and doctoral students. In particular, the aim of the article is to determine the negative characteristics of distance education in higher education, while learning the information and communication technologies, including the postgraduate education, for formulating a comprehensive view of this format of education. Significant characteristics (peculiarities) of the distance education are outlined by author. They are: individualization of the educational process, indirect interaction of participants, and specialization of the environment. Essential advantages (objective need to optimize individual qualities and learning skills; more comfortable learning conditions than in the classroom; saving personal resources) and disadvantages (destruction of social relations; development of deep introverted qualities of the individual; gradual exclusion of the person from socialization; inability and / or unwillingness of individual tutors to adapt their professional skills to new conditions; inadequate level of technical support of the teaching staff, and in some places — students) of distance education are determined by the researcher on the basis of using of content-analysis of pieces for the content of features, mentioned above. The author's reasoning about the list of advantages and disadvantages of distance education is supported and expanded by the in-depth analysis of empirical sources, including scientific researches within the object of research. The advantages and disadvantages of distance postgraduate education according to the criterion of their nature are classified and three basic groups of advantages and disadvantages of the distance education are suggested. It is concluded that the reverse side of the "medal" in the form of distance education contains negative phenomena and processes of technical-technological, psychological and social-communicative nature. It is emphasized, that the consequences of psychological and social-communicative nature can be irreversible and lead to the complete destruction of an individual and the loss of social relations. It is indicated that the best option for further development of educational processes is the rational use of distance learning technologies as a supplement to traditional education.
Effects of pointing movements on visuospatial working memory in a joint-action condition: Evidence from eye movements
Authors: Bhatia Divya , Mohite Vaishnavi , Spataro Pietro , Rossi-Arnaud Clelia , Mishra Ramesh Kumar
Published: September 2021

Previous studies showed that (a) performing pointing movements towards to-be-remembered locations enhanced their later recognition, and (b) in a joint-action condition, experimenter-performed pointing movements benefited memory to the same extent as self-performed movements. The present study replicated these findings and additionally recorded participants’ fixations towards studied arrays. Each trial involved the presentation of two consecutive spatial arrays, where each item occupied a different spatial location. The item locations of one array were encoded by mere visual observation (the no-move array), whereas the locations of the other array were encoded by observation plus pointing movements (the move array). Critically, in Experiment 1, participants took turns with the experimenter in pointing towards the move arrays (joint-action condition), while in Experiment 2 pointing was performed only by the experimenter (passive condition). The results showed that the locations of move arrays were recognized better than the locations of no-move arrays in Experiment 1, but not in Experiment 2. The pattern of eye-fixations was in line with behavioral findings, indicating that in Experiment 1, fixations to the locations of move arrays were higher in number and longer in duration than fixations to the locations of no-move arrays, irrespective of the agent who performed the movements. In contrast, no differences emerged in Experiment 2. We propose that, in the joint-action condition, self- and other-performed pointing movements are coded at the same representational level and their functional equivalency is reflected in a similar pattern of eye-fixations.