bluuebunny/crossref_metadata_2025 huggingface dataset:
Systematic translation and adaptation of the FOCUS program, a USA-based supportive intervention for persons with cancer and their family caregivers, for use in six European countries
Authors: van der Wel Maaike , van der Smissen Doris , Dierickx Sigrid , Cohen Joachim , Hudson Peter , De Vleminck Aline , Tutt Lydia , Scott David , Di Leo Silvia , Arnfeldt Caroline Moeller , Jordan Catherine , Northouse Laurel , Rietjens Judith , van der Heide Agnes , Witkamp Erica
Published: October 2022

Purpose

Having advanced cancer presents many challenges for patients and family caregivers. The FOCUS program is a psychoeducational nurse-led intervention, developed in the USA, to support dyads of patients with cancer and their family caregivers to live with the illness. The program includes a conversation manual and information resources for dyads. We aimed to develop a version of the program for dyads facing advanced cancer in six European countries.

Method

The Participatory and Iterative Process Framework for Language Adaptation (PIPFLA) was used to guide the translation of the program to the local contexts of Belgium, Denmark, Ireland, Italy, the Netherlands, and the UK. In several rounds, potential program users (e.g., nurses, clinicians, patients, family caregivers) and researchers from all six countries reviewed program materials and advised on adaptations.

Results

The PIPFLA process resulted in one European version of the program in different languages (FOCUS +). The FOCUS + conversation manual is uniform across all countries. The main adaptations included additional attention to both family caregiver and patient needs; more emphasis on self-management, advance care planning, and shared responsibilities; discussing the dyad’s outlook rather than optimism; addressing the role of nurses as educational rather than therapeutic; and more suggestions to refer dyads to health care professionals for specific care needs. The information resources for dyads were adapted to fit with local contexts.

Conclusion

The PIPFLA methodology is an efficient and effective framework to thoroughly translate and culturally adapt a complex USA-based program for use in six European countries in collaboration with end users.
Electron transfer of extremophiles in bioelectrochemical systems
Authors: Edel Miriam , Philipp Laura-Alina , Lapp Jonas , Reiner Johannes , Gescher Johannes
Published: October 2022

The interaction of bacteria and archaea with electrodes is a relatively new research field which spans from fundamental to applied research and influences interdisciplinary research in the fields of microbiology, biochemistry, biotechnology as well as process engineering. Although a substantial understanding of electron transfer processes between microbes and anodes and between microbes and cathodes has been achieved in mesophilic organisms, the mechanisms used by microbes under extremophilic conditions are still in the early stages of discovery. Here, we review our current knowledge on the biochemical solutions that evolved for the interaction of extremophilic organisms with electrodes. To this end, the available knowledge on pure cultures of extremophilic microorganisms has been compiled and the study has been extended with the help of bioinformatic analyses on the potential distribution of different electron transfer mechanisms in extremophilic microorganisms.
Efficacy and safety of colchicine for the treatment of osteoarthritis: a systematic review and meta-analysis of intervention trials
Authors: Singh Ambrish , Molina-Garcia Pablo , Hussain Salman , Paul Alok , Das Siddharth Kumar , Leung Ying-Ying , Hill Catherine L. , Danda Debashish , Samuels Jonathan , Antony Benny
Published: October 2022

Objective

Colchicine, an approved treatment for gout, has been trialed in many diseases including osteoarthritis (OA) due to its anti-inflammatory effects. However, its efficacy and safety remain unclear in OA. This systematic review and meta-analysis evaluated the efficacy and safety of colchicine for the treatment of OA.

Methods

PubMed, Web of Science, Scopus, and Cochrane Central were searched from inception through September 2022. Two reviewers independently screened for randomized controlled trials (RCTs) comparing colchicine with placebo or other active comparators for the treatment of OA (knee, hand, or hip OA), extracted data, and performed Cochrane risk of bias assessments.

Result

Nine RCTs for the knee OA and one for the hand OA were identified, consisting of 847 patients (429 in colchicine arms, 409 in control arms). The studies were conducted between 2002 and 2021 with follow-up periods ranging from 2 to 12 months, in India, Iran, Turkey, Australia, Singapore, and Iraq. Moderate-quality evidence showed no clinically important pain reduction with colchicine compared to control (standardized mean difference [SMD], 0.17; 95% confidence interval [CI], − 0.55, 0.22). Moderate-quality evidence showed no improvement in function with colchicine compared to control in knee OA patients (SMD, − 0.37; 95% CI, − 0.87, 0.13). Colchicine showed an acceptable safety profile with AEs/SAEs comparable to control.

Conclusion

Current evidence does not suggest a benefit of colchicine in reducing pain and improving physical function in the overall cohort of hand/knee OA patients. Future trials should focus on the subgroups of OA patients with local or systemic inflammation and/or mineralization who might benefit from colchicine.

Graphical abstract

Key Points•Colchicine is an approved treatment for gout that has been trialed in many diseases including osteoarthritis (OA) due to its anti-inflammatory effects. However, the benefit and harms of colchicine in OA remain unclear.• Current evidence from randomized control trials does not suggest a benefit of colchicine in reducing pain and improving physical function for the treatment of OA patients.• Future trials of colchicine in OA should focus on the subgroups of OA patients with local or systemic inflammation and/or mineralization who might benefit from colchicine.
Life is in motion (through a chick’s eye)
Authors: Lemaire Bastien S. , Vallortigara Giorgio
Published: October 2022

Cognitive scientists, social psychologists, computer scientists, neuroscientists, ethologists and many others have all wondered how brains detect and interpret the motion of living organisms. It appears that specific cues, incorporated into our brains by natural selection, serve to signal the presence of living organisms. A simple geometric figure such as a triangle put in motion with specific kinematic rules can look alive, and it can even seem to have intentions and goals. In this article, we survey decades of parallel investigations on the motion cues that drive animacy perception—the sensation that something is alive—in non-human animals, especially in precocial species, such as the domestic chick, to identify inborn biological predispositions. At the same time, we highlight the relevance of these studies for an understanding of human typical and atypical cognitive development.
Analysis of PMMA versus CaP titanium-enhanced implants for cranioplasty after decompressive craniectomy: a retrospective observational cohort study
Authors: Wesp Dominik , Krenzlin Harald , Jankovic Dragan , Ottenhausen Malte , Jägersberg Max , Ringel Florian , Keric Naureen
Published: October 2022

Numerous materials of implants used for cranioplasty after decompressive craniectomy (DC) have been investigated to meet certain demanded key features, such as stability, applicability, and biocompatibility. We aimed to evaluate the feasibility and safety of biocompatible calcium-phosphate (CaP) implants for cranioplasty compared to polymethylmethacrylate (PMMA) implants. In this retrospective observational cohort study, the medical records of all patients who underwent cranioplasty between January 1st, 2015, and January 1st, 2022, were reviewed. Demographic, clinical, and diagnostic data were collected. Eighty-two consecutive patients with a mean age of 52 years (range 22–72 years) who received either a PMMA (43/82; 52.4%) or CaP (39/82; 47.6%) cranial implant after DC were included in the study. Indications for DC were equally distributed in both groups. Time from DC to cranioplasty was 143.8 ± 17.5 days (PMMA) versus 98.5 ± 10.4 days (CaP). The mean follow-up period was 34.9 ± 27.1 months. Postoperative complications occurred in 13 patients with PMMA and 6 in those with CaP implants (13/43 [30.2%] vs. 6/39 [15.4%]; p = 0.115). Revision surgery with implant removal was necessary for 9 PMMA patients and in 1 with a CaP implant (9/43 [20.9%] vs. 1/39 [2.6%]; p = 0.0336); 6 PMMA implants were removed due to surgical site infection (SSI) (PMMA 6/43 [14%] vs. CaP 0/39 [0%]; p = 0.012). In this study, a biocompatible CaP implant seems to be superior to a PMMA implant in terms of SSI and postoperative complications. The absence of SSI supports the idea of the biocompatible implant material with its ability for osseointegration.
Role of Rotated Head Postures on Volunteer Kinematics and Muscle Activity in Braking Scenarios Performed on a Driving Simulator
Authors: Kempter Fabian , Lantella Lorena , Stutzig Norman , Fehr Jörg , Siebert Tobias
Published: October 2022

Occupants exposed to low or moderate crash events can already suffer from whiplash-associated disorders leading to severe and long-lasting symptoms. However, the underlying injury mechanisms and the role of muscle activity are not fully clear. Potential increases in injury risk of non-nominal postures, i.e., rotated head, cannot be evaluated in detail due to the lack of experimental data. Examining changes in neck muscle activity to hold and stabilize the head in a rotated position during pre-crash scenarios might provide a deeper understanding of muscle reflex contributions and injury mechanisms. In this study, the influence of two different head postures (nominal vs. rotation of the head by about 63 ± 9° to the right) on neck muscle activity and head kinematics was investigated in simulated braking experiments inside a driving simulator. The braking scenario was implemented by visualization of the virtual scene using head-mounted displays and a combined translational-rotational platform motion. Kinematics of seventeen healthy subjects was tracked using 3D motion capturing. Surface electromyography were used to quantify muscle activity of left and right sternocleidomastoideus (SCM) and trapezius (TRP) muscles. The results show clear evidence that rotated head postures affect the static as well as the dynamic behavior of muscle activity during the virtual braking event. With head turned to the right, the contralateral left muscles yielded higher base activation and delayed muscle onset times. In contrast, right muscles had much lower activations and showed no relevant changes in muscle activation between nominal and rotated head position. The observed delayed muscle onset times and increased asymmetrical muscle activation patterns in the rotated head position are assumed to affect injury mechanisms. This could explain the prevalence of rotated head postures during a crash reported by patients suffering from WAD. The results can be used for validating the active behavior of human body models in braking simulations with nominal and rotated head postures, and to gain a deeper understanding of neck injury mechanisms.
“I miss my school!”: Examining primary and secondary school students’ social distancing and emotional experiences during the Covid-19 pandemic
Authors: Letzel-Alt Verena , Pozas Marcela , Schneider Christoph
Published: October 2022

With the rapid spread of Covid-19, countries around the world implemented strict protocols ordering schools to close. As a result, educational institutions were forced to establish a new form of schooling by implementing emergency remote education. Learning from home during the Covid-19 pandemic brought numerous changes, challenges, and stressors to students’ daily lives. In this context, major concerns have been raised based on the reports of students’ negative experiences resulting from social distancing and isolation. Given the impact of Covid-19 on many aspects of students’ lives, in particular their social and school experiences, research that provides insights into the consequences of this health crisis for students’ well-being has become important. This study aims to explore students’ experiences of social distancing and its relation to their negative emotional experiences during Germany’s first Covid-19–related school closure. Findings indicate that both primary and secondary students missed their friends and classmates and that primary school students perceived higher levels of social distancing. However, a linear regression analysis indicated that the older the students were, the more negatively affected they were by social distancing. The implications of the study’s results and further lines of research are discussed.
Does conduction heterogeneity determine the supervulnerable period after atrial fibrillation?
Authors: Heida Annejet , van der Does Willemijn F. B. , van Schie Mathijs S. , van Staveren Lianne N. , Taverne Yannick J. H. J. , Bogers Ad J. J. C. , de Groot Natasja M. S.
Published: October 2022

Atrial fibrillation (AF) resumes within 90 s in 27% of patients after sinus rhythm (SR) restoration. The aim of this study is to compare conduction heterogeneity during the supervulnerable period immediately after electrical cardioversion (ECV) with long-term SR in patients with AF. Epicardial mapping of both atria was performed during SR and premature atrial extrasystoles in patients in the ECV (N = 17, age: 73 ± 7 years) and control group (N = 17, age: 71 ± 6 years). Inter-electrode conduction times were used to identify areas of conduction delay (CD) (conduction times 7–11 ms) and conduction block (CB) (conduction times ≥ 12 ms). For all atrial regions, prevalences and length of longest CB and continuous CDCB lines, magnitude of conduction disorders, conduction velocity, biatrial activation time, and voltages did not differ between the ECV and control group during both SR and premature atrial extrasystoles (p ≥ 0.05). Hence, our data suggest that there may be no difference in biatrial conduction characteristics between the supervulnerable period after ECV and long-term SR in AF patients.

Graphical abstract

The supervulnerable period after AF termination is not determined by conduction heterogeneity during SR and PACs. It is unknown to what extent intra-atrial conduction is impaired during the supervulnerable period immediately after ECV and whether different right and left atrial regions are equally affected. This high-resolution epicardial mapping study (upper left panel) of both atria shows that during SR the prevalences and length of longest CB and cCDCB lines (upper middle panel), magnitude of conduction disorders, CV and TAT (lower left panel), and voltages did not differ between the ECV and control group. Likewise, these parameters were comparable during PACs between the ECV and control group (lower left panel). †Non-normally distributed. cm/s = centimeters per second; mm = millimeter; ms = millisecond; AF = atrial fibrillation; AT = activation time; BB = Bachmann’s bundle; cCDCB = continuous lines of conduction delay and block; CB = conduction block; CD = conduction delay; CT = conduction time; CV = conduction velocity; ECV = electrical cardioversion; LA = left atrium; LAT = local activation times; PAC = premature atrial complexes; PVA = pulmonary vein area; RA = right atrium; SR = sinus rhythm; TAT = total activation time.
Foundation ownership and firm growth
Authors: Block Joern , Fathollahi Reza
Published: October 2022

Prior research has analyzed how different ownership types affect firm growth. Yet, so far, we know little about the effect of foundation ownership on firm growth. This is an important research gap as some of the largest firms in Western and Northern Europe are either fully or partly owned by foundations. Our study addresses this gap and analyzes the effects of foundation ownership on sales and employee growth. Based on a matched sample of foundation- and non-foundation-owned firms from the DACH (Germany, Austria, Switzerland) region, our analyses show that foundation-owned firms grow significantly less than non-foundation-owned firms in terms of sales but not with regard to employees. In addition, we find that the negative effect is stronger for the upper than for the middle or lower quantiles of the growth distribution. Our results can be explained through the characteristics of foundations as owners, particularly their long-term orientation and their goal of preserving the assets of the foundation. It seems that foundations as firm owners avoid the risks associated with extreme sales growth and aim for a risk-averse and conservative growth strategy.
Residential indoor exposure to fine and ultrafine particulate air pollution in association with blood pressure and subclinical central haemodynamic markers of cardiovascular risk among healthy adults living in Perth, Western Australia
Authors: Gilbey Suzanne E. , Reid Christopher M. , Zhao Yun , Soares Mario J. , Huxley Rachel R. , Rumchev Krassi B.
Published: October 2022

Despite that large percentages of individual daily time is spent in the home, few studies have examined the relationship between indoor particulate matter (PM) exposure in residential settings with subclinical indicators of cardiovascular risk. This cross-sectional study investigated associations between exposure to fine (PM2.5) and ultrafine (UFP) PM in domestic indoor environments, with central blood pressure (BP) and component BP measures (pulse pressure, augmented pressure [AP], augmentation index [AIx], mean arterial pressure, pulse wave velocity [PWV]) in 40 non-smoking, otherwise healthy adults (58% women) living in Perth, Western Australia. Overall, in adjusted models, an interquartile range (IQR) increase in PM2.5 was associated with a 3.2 mmHg (95% confidence interval [CI]: 0.99, 5.45) higher diastolic BP, and a 1.8 mmHg lower AP (95%CI: − 3.63, − 0.01) and 0.4 m/s PWV (95%CI: − 0.80, − 0.08), respectively. For the UFP fraction, an IQR increase was associated with a 5.2% higher AIx (95%CI: 0.51, 9.97) and a 0.6 m/s lower PWV (95%CI: − 1.00, − 0.11).

When stratified by sex, higher UFP concentrations were associated with higher DBP and lower PWV among women. Among men, higher UFP concentrations were associated with lower AP. Exposure to domestic indoor fine and ultrafine PM was associated with preclinical indicators of cardiovascular risk and some of these relationships were affected by sex. These findings contribute important evidence linking low-level residential indoor PM exposure with measurable impacts on cardiovascular physiology and may inform preventative recommendations as part of risk profiles for susceptible individuals.
A dynamic analysis of industrial energy efficiency and the rebound effect: implications for carbon emissions and sustainability
Authors: Amjadi Golnaz , Lundgren Tommy , Zhou Wenchao
Published: October 2022

Energy efficiency improvement (EEI) is generally known to be a cost-effective measure for meeting energy, climate, and sustainable growth targets. Unfortunately, behavioral responses to such improvements (calledenergy rebound effects) may reduce the expected savings in energy and emissions from EEI. Hence, the size of this effect should be considered to help design efficient energy and climate targets. Currently, there are significant differences in approaches for measuring the rebound effect. Here, we used a two-step procedure to measure both short- and long-term energy rebound effects in the Swedish manufacturing industry. In the first step, we used data envelopment analysis (DEA) to measure energy efficiency. In the second step, we use the efficiency scores and estimated a derived energy demand equation including rebound effects using a dynamic panel regression model. This approach was applied to a firm-level panel dataset covering 14 sectors in Swedish manufacturing over the period 1997–2008. We showed that, in the short run, partial and statistically significant rebound effects exist within all manufacturing sectors, meaning that the rebound effect decreased the energy and emission savings expected from EEI. The long-term rebound effect was in general smaller than the short-term effect, implying that within each sector, energy and emission savings due to EEI are larger in the long run compared to the short run. Using our estimates of energy efficiency and rebound effect, we further performed a post-estimation analysis to provide a guide to policy makers by identifying sectors where EEI have the most potential to promote sustainable economic growth with the lowest environmental impact.
Screening, diagnosis and follow-up of Brugada syndrome in children: a Dutch expert consensus statement
Authors: Peltenburg P. J. , Hoedemaekers Y. M. , Clur S. A. B. , Blom N. A. , Blank A. C. , Boesaard E. P. , Frerich S. , van den Heuvel F. , Wilde A. A. M. , Kammeraad J. A. E.
Published: October 2022

Brugada syndrome (BrS) is a rare inherited arrhythmia syndrome. Affected children may experience life-threatening symptoms, mainly during fever. The percentage of SCN5A variant carriers in children is higher than in adults. Current diagnostic and follow-up policies for children with (a family history of) BrS vary between centres. Here, we present a consensus statement based on the current literature and expert opinions to standardise the approach for all children with BrS and those from BrS families in the Netherlands. In summary, BrS is diagnosed in patients with a spontaneous type 1 electrocardiogram (ECG) pattern or with a Shanghai score ≥ 3.5 including ≥ 1 ECG finding. A sodium channel-blocking drug challenge test should only be performed after puberty with a few exceptions. A fever ECG is indicated in children with suspected BrS, in children with a first-degree family member with definite or possible BrS according to the Shanghai criteria with a SCN5A variant and in paediatric SCN5A variant carriers. In-hospital rhythm monitoring during fever is indicated in patients with an existing type 1 ECG pattern and in those who develop such a pattern. Genetic testing should be restricted to SCN5A. Children with BrS and children who carry an SCN5A variant should avoid medication listed at www.brugadadrugs.org and fever should be suppressed. Ventricular arrhythmias or electrical storms should be treated with isoproterenol infusion.
Quality early childhood education through self, workplace, or regulatory support: exploring the efficacy of professional registration for early childhood teachers in Australia
Authors: Fenech Marianne , Watt Helen
Published: October 2022

Teacher registration is increasingly utilised as a governance mechanism to audit teachers’ work and drive professional practice. There is limited and mixed empirical evidence, however, as to whether registration drives teaching quality. Our study extends this limited empirical base by critically examining the policy trajectory in Australia to bring early childhood teachers into a uniform system of registration with primary and secondary teachers. Adopting a relatively novel methodology, the study intertwined a critical social policy framing with a national quantitative survey. Results showed that respondents perceived their professional self, followed by their workplace (colleagues and employer) as key influencers of quality practice, and neither agreed nor disagreed that teacher registration was beneficial. Findings problematise the need for, and benefits of, teacher registration. That early childhood teachers’ practice and development was most driven by intrinsic motivation and, to a lesser extent, being employed in high-quality, not-for-profit, and preschool settings where other early childhood teachers are employed, suggests that more effective and progressive policy approaches to support quality early childhood education require an addressing of the contexts and conditions in which early childhood teachers work.
Design guidelines for assessing students’ interprofessional competencies in healthcare education: a consensus study
Authors: Smeets Hester Wilhelmina Henrica , Sluijsmans Dominique M. A. , Moser Albine , van Merriënboer Jeroen J. G.
Published: October 2022

Introduction Healthcare systems require healthcare professionals and students educated in an interprofessional (IP) context. Well-designed assessments are needed to evaluate whether students have developed IP competencies, but we currently lack evidence-informed guidelines to create them. This study aims to provide guidelines for the assessment of IP competencies in healthcare education. Methods A qualitative consensus study was conducted to establish guidelines for the design of IP assessments using the nominal group technique. First, five expert groups (IP experts, patients, educational scientists, teachers, and students) were asked to discuss design guidelines for IP assessment and reach intragroup consensus. Second, one heterogeneous intergroup meeting was organized to reach a consensus among the expert groups on IP assessment guidelines. Results This study yielded a comprehensive set of 26 guidelines to help design performance assessments for IP education: ten guidelines for both the IP assessment tasks and the IP assessors and six guidelines for the IP assessment procedures.
Rational points on hyperelliptic Atkin-Lehner quotients of modular curves and their coverings
Authors: Adžaga Nikola , Chidambaram Shiva , Keller Timo , Padurariu Oana
Published: October 2022

We complete the computation of all$$\mathbb {Q}$$Q-rational points on all the 64 maximal Atkin-Lehner quotients$$X_0(N)^*$$X0(N)∗such that the quotient is hyperelliptic. To achieve this, we use a combination of various methods, namely the classical Chabauty–Coleman, elliptic curve Chabauty, quadratic Chabauty, and the bielliptic quadratic Chabauty method (from a forthcoming preprint of the fourth-named author) combined with the Mordell-Weil sieve. Additionally, for square-free levelsN, we classify all$$\mathbb {Q}$$Q-rational points as cusps, CM points (including their CM field andj-invariants) and exceptional ones. We further indicate how to use this to compute the$$\mathbb {Q}$$Q-rational points on all of their modular coverings.
An Adaptive Elastic Multi-model Big Data Analysis and Information Extraction System
Authors: Yin Qiang , Wang Jianhua , Du Sheng , Leng Jianquan , Li Jintao , Hong Yinhao , Zhang Feng , Chai Yunpeng , Zhang Xiao , Zhao Xiaonan , Li Mengyu , Xiao Song , Lu Wei
Published: October 2022

With the diverse applications to industry and domain-specific context, multi-source information extraction on semi-structured and unstructured data, as well as across data models, is becoming more common. However, multi-model information extraction often requires the deployment of multiple data model management, storage, and analysis subsystems on the cloud, many subsystems are not high-resource utilization at the same time, and the resource waste phenomenon is often serious. Therefore, an adaptive scalable multi-model big data analysis and information extraction system is designed and implemented in this paper, which can support data maintenance and cross-model query of relational, graph, document, key and other data models, and can provide efficient cross-model information extraction. On this basis, we can achieve the system resource allocation on demand and fast scaling mechanism, according to the real-time requirements of multi-model big data analysis, and dynamic adjustment of each subsystem resource allocation. Therefore, our solution not only guarantees multi-model query and information extraction performance and quality of service, but also significantly reduces the total consumption of system resources and cost.
Microbial degradation of virgin polyethylene by bacteria isolated from a landfill site
Authors: Kopecká Romana , Kubínová Ivana , Sovová Kateřina , Mravcová Ludmila , Vítěz Tomáš , Vítězová Monika
Published: October 2022

In this study we evaluate the extent of degradation of high-density polyethylene by bacterial isolates obtained from landfill. The microorganisms are isolated from plastic wastes deposited in the landfill for 2–3 years and 17 years. Experiments are conducted under laboratory conditions to degrade virgin high-density polyethylene used in the manufacture of packaging materials. Gravimetric and GC–MS analyses are performed to describe polyethylene decomposition. Of all the bacterial isolates tested, the degradation of polyethylene by Bacillus cereus is the highest, 1.78%, based on weight loss. On the other hand, degradation by Pseudomonas tuomurensis is 0.3%. Degradation products are detected, confirming the progressive degradation of the plastic. The hydrocarbons with single and double bonds are observed most frequently. Our study provides insight into the microbial biodegradation of polyethylene in the environment and contributes to the understanding of the biodegradation processes that may occur in landfills and their progress.

Article Highlights

Microorganisms isolated from the landfill are capable of high-density polyethylene degradation.

The biodegradation of high-density polyethylene is a slow process.

Out of degradation products the hydrocarbons with single and double bonds were observed most frequently.
Gas permeameter for polymers and nanocomposites: a new equipment
Authors: Pavani Gilberto João , Pavani Sérgio Adalberto , Ferreira Carlos Arthur
Published: October 2022

Information on the gas transport coefficients in the permeation of homogeneous semipermeable materials such as semicrystalline polymers under extreme pressures and temperatures is rarely found in the literature. Therefore, the objective of this work is to showcase innovation regarding the accuracy and usability of the medium pressure and temperature gas permeameter suitable for polymeric and polymeric nanocomposite plates built by the authors, which was tested with nitrogen at 1 MPa and 69 °C (342.15 K) permeating pure high density polyethylene samples (HDPE) and HDPE samples with added nanoclay, redoing the tests published in a previous work on the subject. The results were compared against data obtained previously and information present in the literature, validating the permeameter presented in this work, which is capable of analyzing gas permeability under the described conditions with greater accuracy and ease of operation than the previous model for the values of the transport coefficients of nitrogen permeating HDPE, demonstrating that the implemented improvements and advances were adequate, allowing the measurement of the transport properties of gases permeating polymeric and nanocomposite plates, necessary information for the design of risers for the transportation of oil and natural gas, for example.
Inanspruchnehmende einer Spielsuchtambulanz mit „Doppeldiagnosen“
Authors: Wölfling Klaus , Dreier Michael , Beutel Manfred E. , Müller Kai W.
Published: October 2022

Zusammenfassung: Zielsetzung: Internetnutzungsstörungen werden als wichtiges gesundheitsrelevantes Phänomen akzeptiert und sind bekanntermaßen mit hohen Raten an komorbiden psychischen Erkrankungen assoziiert. Jedoch ist das Wissen über das gleichzeitige Auftreten mit einer weiteren Verhaltenssucht begrenzt. Die vorliegende Arbeit bietet eine erste klinische Charakterisierung bei gleichzeitig auftretender Internetnutzungs- und Glücksspielstörung (Doppeldiagnose). Methodik: Die Analyse beruhte auf einer konsekutiven klinischen Stichprobe von Betroffenen ( N=1813), die sich wegen einer Verhaltenssucht ambulant vorstellten. Daten wurden aus der klinischen Exploration sowie psychometrischen Verfahren zur Erfassung von Depressivität, Stress, Angstsymptomen und Funktionsniveau erhoben und mit Betroffenen, die entweder eine Computerspiel- oder Glücksspielstörung aufwiesen, verglichen. Ergebnisse: Bei n=46 Betroffenen wurde eine Doppeldiagnose gestellt. Diese Gruppe wies zudem eine höhere Anzahl weiterer psychischer Störungen auf. Die Auswertung der klinischen Inventare wies auf eine insgesamt hohe Symptombelastung hin, ohne dass sich die Gruppen signifikant voneinander unterschieden. Schlussfolgerungen: Eine kleine Gruppe Inanspruchnehmender erfüllt die Kriterien einer Internetnutzungs- und einer Glücksspielstörung. Es ergeben sich keine auffälligen Unterschiede in der Symptombelastung zu Betroffenen mit singulärer Abhängigkeit, jedoch ist zu vermuten, dass Doppeldiagnosen eine differenzierte therapeutische Herangehensweise erfordern.
Biomarker in der Diagnostik kognitiver Störungen – Empfehlungen der Swiss Memory Clinics
Authors: Popp Julius , Georgescu Dan , Bürge Markus , Mundwiler-Pachlatko Esther , Bernasconi Luca , Felbecker Ansgar
Published: October 2022

Zusammenfassung. Molekulare Liquormarker der Alzheimer-Kernpathologie (Amyloidpathologie, Tau-Hyperphosphorylierung und neuronaler Zelluntergang) sind Bestandteil des diagnostischen Instrumentariums zur Abklärung kognitiver Störungen im Alter. Sie erlauben eine frühere und präzisere Diagnose und werden von Swiss Memory Clinics als Zusatzdiagnostik nach individuell gestellter Indikation empfohlen. Aufklärung und Beratung sind sowohl vor als auch nach der Biomarker-Diagnostik erforderlich. Die Durchführung der diagnostischen Lumbalpunktion und der präanalytische Umgang mit den Proben richtet sich nach publizierten Standards. Die Interpretation der Resultate muss sorgfältig und im Gesamtkontext aller anderen Befunde erfolgen. Dank bedeutender Fortschritte ist zu erwarten, dass Blutbiomarker und andere kostengünstige und leicht zugängliche Marker sowie spezifische Biomarker für weitere Demenzursachen in wenigen Jahren zur Verfügung stehen werden. Dieser Trend dürfte zu einem deutlich breiteren Einsatz von Biomarkern führen und die Entwicklung wirksamer und personalisiert anwendbarer Präventions- und Behandlungsansätze beschleunigen. Unser Beitrag bietet einen Überblick über den Stand der Entwicklung und beinhaltet Empfehlungen der Swiss Memory Clinics zum Einsatz von Liquormarkern im diagnostischen Prozess.
Eine ungewöhnliche Ursache für reversible, behandelbare Enzephalopathie
Authors: Rakou Stamatia
Published: October 2022

Zusammenfassung. Eine 80-jährige Patientin wurde mit zunehmender Körperschwäche, Dysphagie, Gangstörung und Kognitionsstörung über die vergangenen Monate in unsere Klinik überwiesen. Nach ausführlicher Abklärung stellten wir den hochgradigen Verdacht auf eine Hashimoto-Enzephalopathie als mögliche Ursache der akuten Verschlechterung. Eine Kortisontherapie wurde etabliert, worunter es zu einer Besserung der Symptomatik kam.
Fantastic Ice-Nucleating Particles and How to Find Them
Authors: Burrows Susannah
Published: October 2022

Recent advances in measurements and models are paving the way to transform fundamental understanding and simulation of ice-nucleating particles and their climate impacts.
Treatment biomarkers for ADHD: Taking stock and moving forward
Authors: Michelini Giorgia , Norman Luke J. , Shaw Philip , Loo Sandra K.
Published: October 2022

The development of treatment biomarkers for psychiatric disorders has been challenging, particularly for heterogeneous neurodevelopmental conditions such as attention-deficit/hyperactivity disorder (ADHD). Promising findings are also rarely translated into clinical practice, especially with regard to treatment decisions and development of novel treatments. Despite this slow progress, the available neuroimaging, electrophysiological (EEG) and genetic literature provides a solid foundation for biomarker discovery. This article gives an updated review of promising treatment biomarkers for ADHD which may enhance personalized medicine and novel treatment development. The available literature points to promising pre-treatment profiles predicting efficacy of various pharmacological and non-pharmacological treatments for ADHD. These candidate predictive biomarkers, particularly those based on low-cost and non-invasive EEG assessments, show promise for the future stratification of patients to specific treatments. Studies with repeated biomarker assessments further show that different treatments produce distinct changes in brain profiles, which track treatment-related clinical improvements. These candidate monitoring/response biomarkers may aid future monitoring of treatment effects and point to mechanistic targets for novel treatments, such as neurotherapies. Nevertheless, existing research does not support any immediate clinical applications of treatment biomarkers for ADHD. Key barriers are the paucity of replications and external validations, the use of small and homogeneous samples of predominantly White children, and practical limitations, including the cost and technical requirements of biomarker assessments and their unknown feasibility and acceptability for people with ADHD. We conclude with a discussion of future directions and methodological changes to promote clinical translation and enhance personalized treatment decisions for diverse groups of individuals with ADHD.
Lineage-selective super enhancers mediate core regulatory circuitry during adipogenic and osteogenic differentiation of human mesenchymal stem cells
Authors: Wang Chen , Tian Wen , Hu Shou-Ye , Di Chen-Xi , He Chang-Yi , Cao Qi-Long , Hao Ruo-Han , Dong Shan-Shan , Liu Cong-Cong , Rong Yu , Kang Hua-Feng , Yang Tie-Lin , Yang Zhi , Guo Yan
Published: October 2022

Human mesenchymal stem cells (hMSCs) can be differentiated into osteoblasts and adipocytes. During these processes, super enhancers (SEs) play important roles. Here, we performed comprehensive characterization of the SEs changes associated with adipogenic and osteogenic differentiation of hMSCs, and revealed that SEs changed more dramatically compared with typical enhancers. We identified a set of lineage-selective SEs, whose target genes were enriched with cell type-specific functions. Functional experiments in lineage-selective SEs demonstrated their specific roles in directed differentiation of hMSCs. We also found that some key transcription factors regulated by lineage-selective SEs could form core regulatory circuitry (CRC) to regulate each other’s expression and control the hMSCs fate determination. In addition, we found that GWAS SNPs of osteoporosis and obesity were significantly enriched in osteoblasts-selective SEs or adipocytes-selective SEs, respectively. Taken together, our studies unveiled important roles of lineage-selective SEs in hMSCs differentiation into osteoblasts and adipocytes.
Persistent activity in human parietal cortex mediates perceptual choice repetition bias
Authors: Urai Anne E. , Donner Tobias H.
Published: October 2022

Humans and other animals tend to repeat or alternate their previous choices, even when judging sensory stimuli presented in a random sequence. It is unclear if and how sensory, associative, and motor cortical circuits produce these idiosyncratic behavioral biases. Here, we combined behavioral modeling of a visual perceptual decision with magnetoencephalographic (MEG) analyses of neural dynamics, across multiple regions of the human cerebral cortex. We identified distinct history-dependent neural signals in motor and posterior parietal cortex. Gamma-band activity in parietal cortex tracked previous choices in a sustained fashion, and biased evidence accumulation toward choice repetition; sustained beta-band activity in motor cortex inversely reflected the previous motor action, and biased the accumulation starting point toward alternation. The parietal, not motor, signal mediated the impact of previous on current choice and reflected individual differences in choice repetition. In sum, parietal cortical signals seem to play a key role in shaping choice sequences.
A single arm phase Ib/II trial of first-line pembrolizumab, trastuzumab and chemotherapy for advanced HER2-positive gastric cancer
Authors: Lee Choong-kun , Rha Sun Young , Kim Hyo Song , Jung Minkyu , Kang Beodeul , Che Jingmin , Kwon Woo Sun , Park Sejung , Bae Woo Kyun , Koo Dong-Hoe , Shin Su-Jin , Kim Hyunki , Jeung Hei-Cheul , Zang Dae Young , Lee Sang Kil , Nam Chung Mo , Chung Hyun Cheol
Published: October 2022

In this multi-center phase II trial, we evaluated the efficacy and safety of a quadruplet regimen (pembrolizumab, trastuzumab, and doublet chemotherapy) as first-line therapy for unresectable or metastatic human epidermal growth factor receptor 2 (HER2)-positive advanced gastric cancer (AGC) (NCT02901301). The primary endpoints were recommended phase 2 dose (RP2D) for phase Ib and objective response rate (ORR) for phase II. The secondary endpoints included progression-free survival (PFS), overall survival (OS), duration of response, time to response and safety. Without dose-limiting or unexpected toxicities, the starting dose in the phase Ib trial was selected as RP2D. In 43 patients, the primary endpoint was achieved: the objective response rate was 76.7% (95% confidence interval [CI]: 61.4–88.2), with complete and partial responses in 14% and 62.8% of patients, respectively. The median progression-free survival, overall survival, and duration of response were 8.6 months, 19.3 months, and 10.8 months, respectively. No patients discontinued pembrolizumab because of immune-related adverse events. Programmed death ligand-1 status was not related to survival. Post hoc analyses of pretreatment tumor specimens via targeted sequencing indicated that ERBB2 amplification, RTK/RAS pathway alterations, and high neoantigen load corrected by HLA-B were positively related to survival. The current quadruplet regimen shows durable efficacy and safety for patients with HER2-positive AGC.
Helheim Glacier ice velocity variability responds to runoff and terminus position change at different timescales
Authors: Ultee Lizz , Felikson Denis , Minchew Brent , Stearns Leigh A. , Riel Bryan
Published: October 2022

The Greenland Ice Sheet discharges ice to the ocean through hundreds of outlet glaciers. Recent acceleration of Greenland outlet glaciers has been linked to both oceanic and atmospheric drivers. Here, we leverage temporally dense observations, regional climate model output, and newly developed time series analysis tools to assess the most important forcings causing ice flow variability at one of the largest Greenland outlet glaciers, Helheim Glacier, from 2009 to 2017. We find that ice speed correlates most strongly with catchment-integrated runoff at seasonal to interannual scales, while multi-annual flow variability correlates most strongly with multi-annual terminus variability. The disparate time scales and the influence of subglacial topography on Helheim Glacier’s dynamics highlight different regimes that can inform modeling and forecasting of its future. Notably, our results suggest that the recent terminus history observed at Helheim is a response to, rather than the cause of, upstream changes.
Resolving subcellular pH with a quantitative fluorescent lifetime biosensor
Authors: Rennick Joshua J. , Nowell Cameron J. , Pouton Colin W. , Johnston Angus P. R.
Published: October 2022

Changes in sub-cellular pH play a key role in metabolism, membrane transport, and triggering cargo release from therapeutic delivery systems. Most methods to measure pH rely on intensity changes of pH sensitive fluorophores, however, these measurements are hampered by high uncertainty in the inferred pH and the need for multiple fluorophores. To address this, here we combine pH dependant fluorescent lifetime imaging microscopy (pHLIM) with deep learning to accurately quantify sub-cellular pH in individual vesicles. We engineer the pH sensitive protein mApple to localise in the cytosol, endosomes, and lysosomes, and demonstrate that pHLIM can rapidly detect pH changes induced by drugs such as bafilomycin A1 and chloroquine. We also demonstrate that polyethylenimine (a common transfection reagent) does not exhibit a proton sponge effect and had no measurable impact on the pH of endocytic vesicles. pHLIM is a simple and quantitative method that will help to understand drug action and disease progression.
Inter-valley coherent order and isospin fluctuation mediated superconductivity in rhombohedral trilayer graphene
Authors: Chatterjee Shubhayu , Wang Taige , Berg Erez , Zaletel Michael P.
Published: October 2022

Superconductivity was recently discovered in rhombohedral trilayer graphene (RTG) in the absence of a moiré potential. Superconductivity is observed proximate to a metallic state with reduced isospin symmetry, but it remains unknown whether this is a coincidence or a key ingredient for superconductivity. Using a Hartree-Fock analysis and constraints from experiments, we argue that the symmetry breaking is inter-valley coherent (IVC) in nature. We evaluate IVC fluctuations as a possible pairing glue, and find that they lead to chiral unconventional superconductivity when the fluctuations are strong. We further elucidate how the inter-valley Hund’s coupling determines the spin-structure of the IVC ground state and breaks the degeneracy between spin-singlet and triplet superconductivity. Remarkably, if the normal state is spin-unpolarized, we find that a ferromagnetic Hund’s coupling favors spin-singlet superconductivity, in agreement with experiments. Instead, if the normal state is spin-polarized, then IVC fluctuations lead to spin-triplet pairing.
Structural diversity in three-dimensional self-assembly of nanoplatelets by spherical confinement
Authors: Wang Da , Hermes Michiel , Najmr Stan , Tasios Nikos , Grau-Carbonell Albert , Liu Yang , Bals Sara , Dijkstra Marjolein , Murray Christopher B. , van Blaaderen Alfons
Published: October 2022

Nanoplatelets offer many possibilities to construct advanced materials due to new properties associated with their (semi)two-dimensional shapes. However, precise control of both positional and orientational order of the nanoplatelets in three dimensions, which is required to achieve emerging and collective properties, is challenging to realize. Here, we combine experiments, advanced electron tomography and computer simulations to explore the structure of supraparticles self-assembled from nanoplatelets in slowly drying emulsion droplets. We demonstrate that the rich phase behaviour of nanoplatelets, and its sensitivity to subtle changes in shape and interaction potential can be used to guide the self-assembly into a wide range of different structures, offering precise control over both orientation and position order of the nanoplatelets. Our research is expected to shed light on the design of hierarchically structured metamaterials with distinct shape- and orientation- dependent properties.
Evidence of exciton-libron coupling in chirally adsorbed single molecules
Authors: Doležal Jiří , Canola Sofia , Hapala Prokop , de Campos Ferreira Rodrigo Cezar , Merino Pablo , Švec Martin
Published: October 2022

Interplay between motion of nuclei and excitations has an important role in molecular photophysics of natural and artificial structures. Here we provide a detailed analysis of coupling between quantized librational modes (librons) and charged excited states (trions) on single phthalocyanine dyes adsorbed on a surface. By means of tip-induced electroluminescence performed with a scanning probe microscope, we identify libronic signatures in spectra of chirally adsorbed phthalocyanines and find that these signatures are absent from spectra of symmetrically adsorbed species. We create a model of the libronic coupling based on the Franck-Condon principle to simulate the spectral features. Experimentally measured librational spectra match very well the theoretically calculated librational eigenenergies and peak intensities (Franck-Condon factors). Moreover, the comparison reveals an unexpected depopulation channel for the zero libron of the excited state that can be effectively controlled by tuning the size of the nanocavity. Our results showcase the possibility of characterizing the dynamics of molecules by their low-energy molecular modes using µeV-resolved tip-enhanced spectroscopy.