bluuebunny/crossref_metadata_2025 huggingface dataset:
Influence of cellulose-containing sorbent preparation method based on linen fiber on its functional properties
Authors: Vokurova D. A. , Nikiforova T. E.
Published: October 2022

The creation of biosorbents based on modified flax fiber is aimed at solving the problem of water pollution from heavy metal ions. A method for obtaining a sorbent on the basis of linen fiber including sequential treatment of polysaccharide material with sodium metaperiodate and sodium bisulfite has been developed. Modification conditions for obtaining an effective sorbent have been selected. Equilibrium and kinetics of copper ions sorption with the use of native and modified linen fiber in comparison with Lewatit S100 cationic exchange resin have been studied. It is established that the time of achieving sorption equilibrium in the heterophase system 'aqueous solution of copper sulfate - a modified sorbent' is reduced by 1.5-2 times while the degree of extraction of copper ions is increased by about 1.5 times as compared to the initial fiber. The influence of solution pH on the sorption of copper ions by native flax fiber has been studied. It has been found that in the pH range of the medium 1-7, along with the sorption of Cu ions, the sorption of H ions is observed, which indicates a competitive mechanism of sorption of heavy metal cations and protons with the participation of the cellulose-containing sorbent. Experimental isotherms of copper ions sorption have been processed in linear coordinates of Langmuir's equation that made it possible to determine the values of maximum sorption capacity of sorbents under study which increase in a series: native flax fiber (0.86 mol/kg) < flax fiber, oxidized and treated with sodium bisulfite (1.69 mol/kg) < Lewatit S100 cationite (1.89 mol/kg). Data from infrared spectroscopy and elemental analysis indicate the appearance of new sorption-active groups in the sorbent structure. The sorbent has been tested for purification of aqueous solutions and beverages from heavy metal ions under laboratory conditions. Peculiarities of the sorption of copper (II) ions from juice and white wine have been revealed. It has been found that the obtained modified sorbent on the basis of flax fiber in the purification of beverages is not inferior to the industrial cationic exchange resins in its sorption properties.
Calculation method for heat and mass transfer apparatuses with porous plastic contact devices
Authors: Vasilyev P. S. , Cherikova K. V. , Shagarova A. A. , Reva L. S.
Published: October 2022

The development of effective contact devices for heat and mass transfer apparatuses, which allow increasing the intensity of heat and mass transfer processes, reducing the size and cost of technological equipment, is an important practical task of the modern food industry. In this regard, the high efficiency of foam contact devices is noted, due to the developed specific surface and low hydraulic resistance. In the course of the study, a general classification of these devices has been proposed; schematic diagrams of the constructions of foam packings and trays have been given, a brief comparative analysis of their application area has been carried out. The main stages of calculation of highly efficient heat and mass transfer apparatuses with cellular plastic contact devices, including the determination of the basic geometrical characteristics of cellular materials, packing height (plate thickness), number of packing sections (number of plates), hydraulic resistance of packed and plate apparatus, have been described in detail. An example of an engineering calculation of a distillation heat and mass transfer apparatus with packed and plate-shaped foam contact devices for the separation of a binary mixture "ethyl alcohol - water" has been considered. The results of the calculation are presented in tabular and graphical form and allow us to conclude that it is most expedient to use packed foam contact devices with smaller dimensions and hydraulic resistance.
Acompanhamento de crianças com transtorno do processamento auditivo central por meio de telerreabilitação: resultados preliminares
Authors: Cruz-Santos Anabela , Vendruscolo Vanissia , Cardoso Fabricio Bruno
Published: October 2022

A telerreabilitação é definida como o uso de um conjunto de recursos e tecnologias de informação e comunicação que possibilitam tratamento a distância. Com o avanço da tecnologia de extensa aplicabilidade, a telerreabilitação pode suprir ou minimizar as dificuldades em crianças com Transtorno do Processamento Auditivo Central (TPAC). O objetivo deste estudo consiste em comparar o desempenho das crianças com Transtorno do Processamento Auditivo Central por meio do uso do Programa de Treinamento Auditivo Cognitivo-PAC On-line, viabilizado na modalidade presencial e por intermédio da telerreabilitação (mediante uma plataforma WEB construída para o efeito) e seus contributos para um currículo adaptado às suas necessidades e dificuldades. A amostra foi composta por 23 crianças entre 7 e 9 anos de idade, com histórico de dificuldades escolares, 13 do Grupo I – telerreabilitação e 10 do Grupo II – treinamento auditivo acusticamente controlado em cabine, em 10 sessões de meia hora. Os testes utilizados foram PSI na condição MCI S/R -15, e DD, nas habilidades de integração e separação binaural. Pais responderam aos questionários QFisher. Os resultados evidenciam efetividade do treinamento auditivo cognitivo por meio da telerreabilitação, com desempenho equivalente ao treinamento auditivo neurocognitivo acusticamente controlado. O conteúdo da plataforma é eficaz para treinamento auditivo, tanto para treinamento auditivo acusticamente controlado quanto para telerreabilitação. O encurtamento das distâncias promovido pela telerreabilitação favorece tanto as pessoas que moram em regiões desprovidas de profissionais especialistas como aquelas que moram nas grandes cidades, favorecendo a frequência do treinamento auditivo e melhorando a aprendizagem escolar dos alunos.
Distribuição de leitos e impactos socioeconômicos da Covid-19 na região funcional 7, RS, Brasil
Authors: Battisti Iara Denise Endruweit , Smolski Felipe Micail da Silva , Rotta Edemar
Published: October 2022

Objetivo: O objetivo deste artigo é verificar a situação da distribuição de hospitais, da oferta de leitos hospitalares e ventilação mecânica nos municípios da Região Funcional 7 (RF-7) do Rio Grande do Sul (Brasil) e inferir possíveis impactos socioeconômicos da nova Síndrome Respiratória Aguda Grave (SARS-CoV-2) - Coronavírus, conhecida como COVID-19. Métodos: utilizaram-se dados do DATASUS de maio de 2020, para a disponibilidade de acesso hospitalar e equipamentos, os dados do IBGE para distribuição etária e população. Para inferir os impactos socioeconômicos, utilizaram-se o número de casos de coronavírus e número de casos por cada cem mil para a data de 11 de julho de 2020 como variáveis dependentes e, para covariáveis as informações do Censo de 2010 dos constructos Demografia e Saúde, Educação, Habitação, Renda, Trabalho e Vulnerabilidade. Resultados: evidencia-se que muitos munícipes dependem de deslocamentos para os atendimentos das unidades hospitalares, bem como nos municípios menores é que existe maior percentual de população idosa na relação com a população total. Pelas regressões estimadas, pode-se inferir que os fatores socioeconômicos associados com a disseminação do vírus tendem a afetar, de forma mais intensa, os Coredes Celeiro e Missões; e que as dimensões Educação, Habitação, Renda e Trabalho possuem variáveis que impactam diretamente na evolução da pandemia na região. Conclusões: a crise de saúde evidenciada pela pandemia impõe desafios aos agentes públicos, portanto para seu enfrentamento são necessárias estratégias que levem em conta a capacidade regional de atendimento do sistema de saúde e as diferenças socioeconômicas locais, fatores que podem estar estimulando o avanço da COVID-19.
Consumer Behaviour of Generation Y and Z during the Pandemic: Attitude Change towards Restaurants and Delivery
Authors: Nyikos Bendegúz Richárd
Published: October 2022

With the appearance of the coronavirus, companies across several industries were required to alter their business models in order to avoid going bankrupt. Hospitality is commonly considered as one the most vulnerable industry for pandemics, therefore the decline on a global scale was inevitable. The occupancy rate of European hotels experienced an overall significant decline in 2020 and reached the lowest peak in May at 13.3%. Compared to the data from May 2019, this meant a drop of 82.3%. Restaurants also felt the negative effect of the pandemic: compared to the data of 2019, at the end of February, European restaurants started to experience declines on a daily basis. With the additional unfortunate events and governmental restrictions, not even in a single month were restaurants able to achieve the number of customers served that they reported in 2019. Even though restaurants on a global scale were seriously impacted by the COVID-19 pandemic, the role of delivery services and food delivery applications (FDAs) has significantly grown and the number of global customers is still increasing. The market size of the global online food delivery sector was 107.44 billion US Dollars in 2019 and expected to reach 154.34 by the end of 2023. There is a wide range of factors that influences consumer behaviour such as quality of information, the design and accessibility, reduction on waiting time and experiences regarding online orders. This research aims to uncover the significance of these dimensions with the support of a primary research conducted in Hungary in order to discover whether the international trends are also applicable in the country.
Lovak, lovasok, lovardák – lovasturizmus Magyarországon és a Fertő-tájon
Authors: Obádovics Csilla
Published: October 2022

Magyarországon nagy és történelmi hagyományai vannak a lótenyésztésnek, a lovassportnak és a lovaglásnak. A magyarokat általában lovas nemzetnek tekintik. A 19. században jelentős fejlődés indult meg a lótenyésztésben, a lóversenyzésben és a hobbilovaglásban. A fejlődés lelassult, mivel a lovakkal kapcsolatos ágazatok, mint a turizmus, a civil szervezetek és a vállalkozói vállalkozások, a kulturális és történelmi örökséghez szorosan kötődő ágazatok a rendszerváltás előtti időkben háttérbe szorultak. A lovak száma a rendszerváltás utáni elmúlt néhány évtizedben nőtt, csakúgy, mint a lovas turizmussal vagy a lovakkal kapcsolatos kulturális örökséggel foglalkozó civil szervezetek, vállalkozók száma. Hazánkban fontos szerepe van a lovasturizmusnak, mely a magyar idegenforgalom egyik vonzereje. Hazánk legszebb tájain, rétjein, erdeiben még szabadon lehet lovagolni. Folyamatban van az egész országot átívelő lovastúra útvonal kialakítása, a megfelelő szálláshelyek feltérképezése, lovas pihenőhelyek létrehozása. A lovastúrák szereplői a lovasok, a lovak, a lovardák, a szállásadók, vendéglátóhelyek, és a túraútvonal. 587 regisztrált lovarda szerepel a nyilvántartásban, 418 lovarda tevékenységei között szerepel a Tereplovaglás, túrázás. Több mint 3500 vizsgáztatott ló van. A lovardák patkós minősítése jelzi a színvonalat és a tevékenységek sokszínűségét. A Fertő- tó környékén lévő településeken több lovarda található. Ezek egy része versenysport istálló, vagy bértartó hely, van lovasiskola, de túrázással, túraszervezéssel és turizmust kiszolgáló lovagoltatással csak a Fertő-parti Lovasklub foglalkozik. Évente megrendezésre kerülő lovastúra a Széchenyiek nyomában c. túra, ahol a lovaglás, lovaskocsis kirándulás mellett a kultúrkörnyezet megismerése is cél.
Current assumptions for quantitative microbial risk assessment (QMRA) of Norovirus contamination of drinking water catchments due to recreational activities: an update
Authors: Deere Dan , Ryan Una
Published: October 2022

Contamination of drinking water from Norovirus (NoV) and other waterborne viruses is a major public health concern globally. Increasingly, quantitative microbial risk assessment (QMRA) is being used to assess the various risks from waterborne pathogens and evaluate control strategies. As urban populations grow and expand, there is increasing demand for recreational activities in drinking water catchments. QMRA relies on context-specific data to map out the pathways by which viruses can enter water and be transferred to drinking water consumers and identify risk factors and appropriate controls. This review examines the current evidence base and assumptions for QMRA analysis of NoV and other waterborne viral pathogens and recommends numerical values based on the most recent evidence to better understand the health risks associated with recreators in Australian drinking water sources; these are broadly applicable to all drinking water sources where recreational access is allowed. Key issues include the lack of an agreed upon data and dose-response models for human infectious NoV genotypes, faecal shedding by bathers, the extent of NoV infectivity and aggregation, resistance (secretor status) to NoV and the extent of secondary transmission.
Análisis comparativo de las narrativas de La civilización del espectáculo y La sociedad del cansancio
Authors: Barriga Barriga Tomás Carlos M.
Published: October 2022

El presente artículo tiene como objetivo analizar las narrativas de la civilización del espectáculo y la sociedad del cansancio como dos propuestas complementarias que explican la realidad actual influenciada por los medios de comunicación y la consecuente banalización de la cultura y la autoexplotación.
Determining the Therapeutic Potential of Experimental Antibacterial Agents: The Use of Animal Models
Authors: Alder Jeffrey D.
Published: October 2022

Animal models of infection are the most predictive preclinical test for projecting clinical success of experimental antibacterial therapeutics. The first screen for antibacterial drug efficacy is usually prevention of mortality in animal models of infection. Secondary trials for drug efficacy measure the reduction of bacterial burden in defined body sites such as lung, kidney, and soft tissue. These trials determine potential clinical indications for the experimental compounds. Promising compounds are then advanced for additional testing in animal models to identify the key pharmacodynamic
parameter predictive of efficacy. The value of the pharmacodynamic parameter that yields efficacy is then numerically defined and related to the blood concentration of experimental drug needed for clinical efficacy. Animal trials to determine appropriate length of therapy are conducted at optimal pharmacodynamic values. Efficacy against relevant drug resistant bacteria should also be determined prior to clinical development. Preliminary toxicity studies are conducted during efficacy testing and safety margins should be known prior to bulk synthesis of drug for formal toxicity studies. At all stages of testing, appropriate clinical antibacterial drugs are used as positive controls. Proper use of animal models will keep the drug development pipeline clear of compounds with little probability of clinical efficacy. This testing program will cause. the selection of experimental anti-bacterial compounds with significant promise for rapid advancement through clinical trials to medical and commercial success.
Artificial Intelligence Approaches in Drug Discovery: Towards the Laboratory
of the Future
Authors: Frusciante Luisa , Visibelli Anna , Geminiani Michela , Santucci Annalisa , Spiga Ottavia
Published: October 2022

The role of computational tools in the drug discovery and development process is becoming central, thanks to the possibility to analyze large amounts of data. The high throughput and affordability of current omics technologies, allowing quantitative measurements of many putative targets, has exponentially increased the volume of scientific data available. The quality of the data and
the speed with which in silico predictions can be validated in vitro is instrumental in accelerating
clinical laboratory medicine, significantly and substantially impacting Precision Medicine (PM).
PM affords the basis to develop new drugs by providing a wide knowledge of the patient as an essential step towards individualized medicine. It is, therefore, essential to collect as much information and data as possible on each patient to identify the causes of the different responses to drugs
from a pharmacogenomics perspective and to identify biological biomarkers capable of accurately
describing the risk signals to develop specific diseases. Furthermore, the role of biomarkers in early
drug discovery is increasing, as they can significantly reduce the time it takes to develop new drugs.
This review article will discuss how Artificial Intelligence fits in the drug discovery pipeline, covering the benefits of an automated, integrated laboratory framework where the application of Machine
Learning methodologies to interpret omics-based data can avail the future perspective of Translational Precision Medicine.
The Role of Cartilage Stem/Progenitor Cells in Cartilage Repair in
Osteoarthritis
Authors: Hu Ning , Qiu Jingwen , Xu Bo , Zhang Shunhao , Guo Zijian , Xie Jing , Yang Wenbin
Published: October 2022

Osteoarthritis (OA) is a degenerative joint disease characterized by the loss of cartilage, which
seriously affects the quality of patient's life and may even cause permanent sequelae. The treatment of OA
is diversified, mostly limited to relieving clinical symptoms. Less invasive treatments that can cure OA
are still lacking. With the rise of tissue-cell engineering, stem cell therapy has gradually aroused great
interest in treating OA. Cartilage stem/progenitor cells (CSPCs), a type of stem cell found on the surface
of articular cartilage, have many similarities with mesenchymal stem cells (MSCs). These cells can be
isolated and cultured from animals and humans and exist in articular cartilage over the body, such as the
knee joint, patellofemoral joint, and temporomandibular joint. Due to their strong proliferative and chondrogenic
differentiation abilities, CSPCs may contribute a lot to cartilage regeneration and repair in OA.
We will provide an overview of the biological characteristics of CSPCs and their role in OA in combination
with the research progress. Despite some existing limitations, CSPCs still offer an innovative idea for
OA treatment with great advantages.
Cognitive Remediation Virtual Reality Tool a Recovery-Oriented Project for People with Bipolar Disorder: Protocol of a Feasibility Randomized Clinical Trial
Authors: Perra Alessandra , De Lorenzo Valerio , Zaccheddu Rosanna , Locci Aurora , Piludu Federica , Preti Antonio , Di Natale Lorenzo , Galetti Alessia , Nardi Antonio Egidio , Cossu Giulia , Sancassiani Federica , Barbato Simone , Cesaretti Ottavio , Kurotshka Peter Konstantin , Carta Mauro G.
Published: October 2022

Introduction:

Cognitive deficits are considered a fundamental component of bipolar disorder due to the fact that they negatively impact personal/social functioning. Cognitive remediation interventions are effective in the treatment of various psychosocial disorders, including bipolar disorder. The use of Virtual reality as a rehabilitation tool has produced scientific evidence in recent years, especially in cardiovascular, neurological, and musculoskeletal rehabilitation. This study aims at evaluating the feasibility of a Cognitive Remediation Virtual Reality Program (CEREBRUM) for people with bipolar disorder in psychiatric rehabilitation.

Material and Methods:

Feasibility randomized controlled cross-over clinical study; we randomized 50 people from the Consultation and Psychosomatic Psychiatry Center of the University Hospital of Cagliari (San Giovanni di Dio Civil Hospital) with a diagnosis of bipolar disorder. We propose a cognitive remediation program in virtual reality (CEREBRUM), 3 months with 2 weekly sessions, for the experimental group and a usual care program for the control group (psychiatric visit and/or psychotherapy).

Results:

The results of the trial will be published in international peer-reviewed journals and will be disseminated at international meetings and congress.

Discussion:

This RCT aims, with regards to its feasibility and design, to provide information about a confirmatory trial that evaluates the effectiveness of a Virtual Reality Cognitive Remediation program in psychiatric rehabilitation for the treatment of cognitive dysfunction in people with bipolar disorder.

Conclusion:

The results that we analyzed at the end of the RCT will have an impact on psychiatric rehabilitation research with a focus on improving the application of technologies for mental health.

Trial registration: ClinicalTrialsgov NCT05070065, registered on September 2021.
Atorvastatin's Reduction of Alzheimer's Disease and Possible Alteration
of Cognitive Function in Midlife as well as its Treatment
Authors: Shah Umang , Shah Aneri , Patel Sandip , Patel Alkesh , Patel Mehul , Solanki Nilay , Patel Swayamprakash , Patel Ashish , Patel Veena , Patel Bhavesh
Published: October 2022

Over the past 20 years, advances in the field of pathogenesis have inspired researchers to
look into novel pharmacological therapeutics that are more focused on the pathophysiological events
of the disease (AD). This review article discussed the prior use of statins for the prevention of Alzheimer's
disease, which can help prevent the disease. Other drugs, such as memantine and donepezil, are
available, but they cannot prevent the onset of AD in middle age. Based on available clinical data, the
valuable effects of statins are mediated by alteration of β-amyloid (Aβ) and tau metabolism, genetic
and lifestyle risk factors, along with other clinical aspects of AD. These findings suggested that using
statins in middle age may help to prevent Alzheimer's disease by modifying genetic and non-genetic
risk factors in later stages of life. In the present review, we elaborated upon the modification of risk
factors and amyloid metabolism in the development and progression of AD and their modulation
through atorvastatin. Future directions in the research and treatment of Alzheimer's disease patients
include the use of antisense oligonucleotides (ASO) to change target expression, and researchers discovered
decreased markers of oxidative stress in tissues affected by tau pathology in response to RNA
interference treatment.
A Review of Thermal Effect of Hydrostatic Bearing
Authors: Yang Xiaodong , Zhang Jian , Liu Hongbo , Liu Xianli , Liu Feilin , Liu Wei Feng
Published: October 2022

Background:

With the continuous development of the modern machinery industry, the technical level of rotating machinery is increasing. As a key component of the bearing system and power transmission system in rotating machinery, the hydrostatic bearing has higher performance requirements in all aspects. When the system is working normally, due to the shearing effect of the lubricating oil driven by the spindle rotation, a large amount of heat will be generated. The system will generate thermal effects on the bearing through heat accumulation and heat conduction. The thermal effect will directly reduce the viscosity of the hydraulic oil, affecting the bearing capacity. Seriously, it will cause thermal deformation of the parts, which will affect the normal operation of the bearing, and even cause an accident.

Objective:

Analysis and discussion on the thermal effect of hydrostatic bearing in recent years

Method:

More than 70 recently published patents were reviewed, as well as journal and conference papers on hydrostatic bearings. The results of temperature fields, pressure fields, deformation, lubrication, bearing capacity and friction were studied.

Results:

This review summarizes the research results from three aspects: the influencing factor of temperature rise, the influence of temperature rise on bearing structure and performance, and the effective control of temperature rise.

Conclusion:

The relevant research methods are analyzed. The problem of thermal effect of hydrostatic bearing is summarized and prospected, and the future development can be expected.
Magnitude of Multidrug-resistant Bacterial Uropathogens and Associated Factors in Urinary Tract Infection Suspected Adult HIV-Positive Patients in Southern Ethiopia
Authors: Simeneh Elias , Gezimu Tigist , Woldemariam Melat , Alelign Dagninet
Published: October 2022

Background:

Due to the reduction of their immunity, people living with the human immunodeficiency virus (HIV) are more susceptible to acquiring urinary tract infections (UTI). Moreover, the emergence of drug-resistant bacterial uropathogens has grown widely and now constitutes a severe clinical problem among HIV-positive patients.

Methods:

An institution-based cross-sectional study was conducted at the ART clinic of Arba Minch General Hospital from 1st January to 30th May, 2021. A total of 251 adult HIV-positive patients clinically suspected of having UTIs were systematically recruited. Socio-demographic and other factors were collected by a pre-tested structured questionnaire. A clean-catch mid-stream urine sample was collected and inoculated onto blood agar, MacConkey agar, and cysteine lactose electrolyte deficient agar (CLED). The inoculated culture media were incubated aerobically at 37°C for 24 hrs. After overnight incubation, significant bacteriuria, 105 CFU/ml, was considered. Bacterial identification was made by standard protocols. Antimicrobial susceptibility testing was done by Kirby Bauer’s disk diffusion method. The data was analyzed using SPSS version 25. A P-value less than 0.05 was used as statistical significance.

Results:

The overall magnitude of multidrug-resistant (MDR) uropathogens was found to be 14.3%, with a 95% CI (10-19.1). Gram-negative bacteria (83.3%) were the predominant MDR isolates, with E. coli (41.7%) followed by K. pneumoniae (22.2%). All isolates of S. aureus and two-thirds of the isolated CoNS were MDR. A total of 30% and 16.7% of Gram-negative isolates were ESBL and carbapenemase producers, respectively, whereas 50% and 33.3% of isolated S. aureus and CoNS were methicillin-resistant, respectively. Antibiotic use in the previous 6 months [AOR = 6.7, 95% CI: (2.53-17.6)], presence of chronic underlying disease [AOR = 7.03, 95% CI: (1.72-28.73)], antibiotic use without a prescription [AOR = 9.7, 95% CI: (3.53-26.675)], CD4+ counts less than 250 cells/mm3 [AOR = 8.05, 95% CI: (2.078–31.154)], and CD4+ count in between 250-500 cells/mm3 [AOR = 2.49, 95% CI: (1.05-5.923)] were found to be statistically significant associated with MDR uropathogens.

Conclusion:

This study found a significant number of multidrug-resistant uropathogens, indicating that healthcare providers should be aware of this and take urgent action to minimize resistance spread, as well as consider current empirical antibiotic therapy for UTI in HIV-positive patients.
Fathoming the Role of mTOR in Diabetes Mellitus and its Complications
Authors: Faheem  , Sivasubrmanian Shanthi
Published: October 2022

Mechanistic/Mammalian target of rapamycin (mTOR) orchestrates cellular homeostasis
by controlling cell growth, proliferation, metabolism, and survival by integrating various growth
factors, nutrients and amino acids. Eccentric synchronization of mTOR has been incriminated in
various diseases/disorders like cancer, neurodegenerative disorders, and diabetes mellitus and its
complications. Recent reports also highlight the role of mTOR in diabetes and its associated complications.
This review tries to fathom the role of mTOR signaling in diabetes mellitus and its
complications- diabetic cardiomyopathy, diabetic nephropathy, and diabetic retinopathy and highlights
mTOR as a putative target for the development of novel anti-diabetic drug candidates.
The Development and Progress in Machine Learning for Protein Subcellular Localization Prediction
Authors: He Le , Liu Xiyu
Published: October 2022

Protein subcellular localization is a novel and promising area and is defined as searching for the specific location of proteins inside the cell, such as in the nucleus, in the cytoplasm or on the cell membrane. With the rapid development of next-generation sequencing technology, more and more new protein sequences have been continuously discovered. It is no longer sufficient to merely use traditional wet experimental methods to predict the subcellular localization of these new proteins. Therefore, it is urgent to develop high-throughput computational methods to achieve quick and precise protein subcellular localization predictions. This review summarizes the development of prediction methods for protein subcellular localization over the past decades, expounds on the application of various machine learning methods in this field, and compares the properties and performance of various well-known predictors. The narrative of this review mainly revolves around three main types of methods, namely, the sequence-based methods, the knowledge-based methods, and the fusion methods. A special focus is on the gene ontology (GO)-based methods and the PLoc series methods. Finally, this review looks forward to the future development directions of protein subcellular localization prediction.
Pulses as Sustainable Protein Sources: Benefits, Drawbacks, and Gaps
Authors: Karakaya Sibel
Published: October 2022

Pulses have redeemed the interest in terms of a sustainable and healthy diet due to their
high protein content. Furthermore, the vitamins, minerals, and phytochemicals they contain also make
them more valuable nutritionally. A sustainable diet should improve public health and food security
and has a low environmental footprint. Pulses have been considered one of the emerging plant food
proteins. Although they have beneficial components such as vitamins, minerals, phytochemicals, and
antioxidants, many drawbacks limit their use to consumers and the food industry. One of the drawbacks
is their incomplete proteins due to the lack of sulfur-containing amino acids in their protein profile.
Furthermore, the protein digestibility of pulses is low due to the antinutritional compounds they
contain. The other drawback of pulses is their beany flavor and bitter taste that limits the acceptability
of consumers. From the consumer's point of view, the other disadvantage is the laborious and timeconsuming
preparation period.

:

This article provides a concise overview of the current state of knowledge on pulses as sustainable
protein sources, underlining the gaps that limit their extensive application in the food industry. Based
on the available scientific facts on pulses, finding an efficient method for removing beany flavor and
overall sensorial acceptability and antinutritional factors, thus increasing protein digestibility is crucial.
The most promising option to increase pulse protein digestibility seems to combine conventional
and novel technologies that can modulate digestibility by different mechanisms, such as the removal
of antinutritional factors, protein denaturation, and the design of the food matrix.
Effect of capital structure on profitability and its implications on financial performance PT BRI Sharia TBK
Authors: Surya Andi , Ekatama M. Renandi
Published: October 2022

This study aims to analyze the effect of structure on profitability and its implications for financial performance at PT. BRI Syariah Tbk period 2016- 2018. The population in this study is in the form of 36 financial statements. The sample in this study is the 2016-2018 financial statements. Hypothesis testing in this study using multiple linear regression. Simultaneously, DER and DAR have a significant and significant effect on profitability. Simultaneously DER and DAR affect financial performance. The coefficient of determination obtained by 42.5% indicates that DER and DAR have the ability to explain profitability, while the remaining 57.5% is explained by variables not examined in this study. The coefficient of determination obtained is 73.1% indicating that DER and DAR have the ability to explain financial performance, while the remaining 26.9% is explained by variables not examined in this study and a coefficient of determination of 57.4% indicates that profitability has the ability to explains financial performance, while the remaining 42.6% is explained by variables not examined in thisstudy.
Food Delivery Drivers’ Health Literacy Regarding COVID-19 Prevention and Protective Behaviors During the COVID-19 Pandemic: Cross-sectional Survey in Southern Thailand
Authors: Jandee Kasemsak , Thanapop Chamnong
Published: October 2022

Background

In 2019, COVID-19 spread worldwide, causing a pandemic that has posed unprecedented challenges and pressure for health systems and economies. Food delivery services have become an important medium for consumer food purchases to limit human-to-human contact. Thus, delivery drivers are at high risk of exposure to COVID-19 infection at work. To the best of our knowledge, no studies have analyzed the dimensions of health literacy (HL) regarding COVID-19 prevention in this population.

Objective

This study aims to explore the HL status toward COVID-19 prevention and its associated factors among food delivery drivers in southern Thailand.

Methods

Following a cross-sectional survey from July to August 2021, Thai food delivery drivers in the upper-south and lower-south regions of southern Thailand were recruited to participate during the compulsory COVID-19 lockdown. An online structured questionnaire was administered verbally and recorded by the interviewer. Univariate and multivariate linear regressions were used to explore independently associated factors.

Results

Of 401 drivers, 291 (72.6%) were men. The median age was 31 years (range 19-64 years). The median number of months working as a driver was 12 months, and the median number of working hours was 9 hours per day. The median number of daily food orders was 20, while the median daily income was Thai baht (THB) 600 (US $15.90). Social media (Facebook and Line) was a common source of health information. The most common information required was about the COVID-19 vaccine, medications, and treatment. Most drivers (285/401, 71.1%) had excellent HL levels regarding COVID-19 prevention. Only the practical application of information was statistically correlated with behavior (r=0.38, P<.001). Drivers in the lower south of Thailand were more likely to have excellent HL than other drivers (β=7.03, P<.001). Those who frequently accessed information through YouTube (β=–2.17, P=.01) and relatives (β=–4.19, P<.001) were less likely to have excellent HL levels.

Conclusions

Understanding HL among food delivery drivers would be useful for planning effective interventions that target this population. Conventional health education through social media alone may not be effective at educating people about COVID-19 prevention. Information literacy skills could determine individuals’ HL and drivers’ behaviors.
Approaches to Research Ethics in Health Research on YouTube: Systematic Review (Preprint)
Authors: Tanner Joshua P , Takats Courtney , Lathan Hannah Stuart , Kwan Amy , Wormer Rachel , Romero Diana , Jones Heidi E
Published: October 2022

BACKGROUND

YouTube has become a popular source of health care information, reaching an estimated 81% of adults in 2021; approximately 35% of adults in the United States have used the internet to self-diagnose a condition. Public health researchers are therefore incorporating YouTube data into their research, but guidelines for best practices around research ethics using social media data, such as YouTube, are unclear.

OBJECTIVE

This study aims to describe approaches to research ethics for public health research implemented using YouTube data.

METHODS

We implemented a systematic review of articles found in PubMed, SocINDEX, Web of Science, and PsycINFO following PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines. To be eligible to be included, studies needed to be published in peer-reviewed journals in English between January 1, 2006, and October 31, 2019, and include analyses on publicly available YouTube data on health or public health topics; studies using primary data collection, such as using YouTube for study recruitment, interventions, or dissemination evaluations, were not included. We extracted data on the presence of user identifying information, institutional review board (IRB) review, and informed consent processes, as well as research topic and methodology.

RESULTS

This review includes 119 articles from 88 journals. The most common health and public health topics studied were in the categories of chronic diseases (44/119, 37%), mental health and substance use (26/119, 21.8%), and infectious diseases (20/119, 16.8%). The majority (82/119, 68.9%) of articles made no mention of ethical considerations or stated that the study did not meet the definition of human participant research (16/119, 13.4%). Of those that sought IRB review (15/119, 12.6%), 12 out of 15 (80%) were determined to not meet the definition of human participant research and were therefore exempt from IRB review, and 3 out of 15 (20%) received IRB approval. None of the 3 IRB-approved studies contained identifying information; one was explicitly told not to include identifying information by their ethics committee. Only 1 study sought informed consent from YouTube users. Of 119 articles, 33 (27.7%) contained identifying information about content creators or video commenters, one of which attempted to anonymize direct quotes by not including user information.

CONCLUSIONS

Given the variation in practice, concrete guidelines on research ethics for social media research are needed, especially around anonymizing and seeking consent when using identifying information.

CLINICALTRIAL

PROSPERO CRD42020148170; https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=148170
Experimental study of pervious concrete
Authors: Jagtap Priya , Victor Oshin , Verma Rakesh
Published: October 2022

In the construction sector, concrete is a widely utilized building material. Pervious concrete is a high-porosity concrete used for concrete flatwork applications that allows water from precipitation and other sources to pass directly through, decreasing runoff and permitting groundwater recharge. The main objective is to determine the strength of pervious concrete by introducing admixture. The results of an experimental inquiry on pervious concrete are given and analysed in this overview. The amount of general-purpose water in pervious concrete has been minimized by utilizing super plasticizer to enhance the strength of pervious concrete and to develop inexpensive pervious concrete. The mix design for pervious concrete was prepared, concrete specimen samples were manufactured, and tests were performed on pervious concrete specimens to determine the strength of pervious concrete and compare it to conventional concrete.
Effects of dietary avocado meal on production performance, carcass traits, muscle fatty acid composition and gene expression of pigs
Authors: Lemus-Flores Clemente , Bugarín Prado Job Oswaldo , Grageola Núñez Fernando , Mejía Martínez Karina , Valdivia Bernal Roberto , Segura Correa José Candelario
Published: October 2022

Dietary avocado meal (AM) may improve growth and muscle fatty acid composition in pigs due to the expression of genes. Transcriptome analysis of Longissimus dorsi muscle and liver and the effect of 0, 5 and 10 % AM in the feed of Landrace-Yorkshire pigs on growth, carcass, muscle fatty acid composition and blood metabolites were evaluated. Twenty-four castrated males with an initial weight of 55 ± 3 kg were distributed under a completely random design. Transcriptome analysis was carried out with massive sequencing, with EdgeR and DESeq2 methods for differentially gene expression (DGE; P ≤ 0.01, log2 fold change ≤ 1.5). We observed higher DGE in both tissues, with down log2 fold change, by including 5 or 10 % AM in the diet against AM0. Genes associated with lipid metabolism (down ANO3; up GOS2, MYLIP, PLIN4), growth (down FOS, MT1A, MT1D, PHGDH; up ARNTL) circadian clock (down DBP, NOCT, PER1, PER2, PER3, SIK1; up ARNTL), immune system (down CD163, CRP, OTUD1; up C1QTNF7, NFIL3) and antioxidative activity (up HP and NCF4) were observed.  The inclusion of AM in the diets increased daily gain, feed intake, slaughtered body weight, carcass weight and ham (P < 0.05). Back fat was greater for AM10 (P < 0.001). AM in the diet decreased intramuscular fat and had less triglycerides in the blood (P < 0.05). AM10 in the diet modified the gene expression and quality of the IMF, had more linoleic acid, total fatty acids Ω6, ∑polyunsaturated fatty acids, PUFA/SFA, and PUFA/MUFA (P < 0.001)
Antifungal Chitinase Production by Bacillus paramycoides B26 using Squid Pen Powder as a Carbon Source
Authors: Kurniawan Edy , Leelakriangsak Montira , Panphon Somrak
Published: October 2022

This study aimed to optimize the medium compositions and cultural conditions for improved chitinase production by a potential strain of Bacillus isolated from the marine environment and determine the antifungal activity of its chitinase against plant pathogenic fungi. Five potential isolates were cultured for chitinase production by submerged fermentation using colloidal chitin in a liquid medium. In this study, chitinase activity was determined by measuring reducing sugars, which were determined by the 3,5-dinitrosalicylic acid (DNS) assay. The most potential isolate, B26, showed similarity to Bacillus paramycoides based on the 16S rRNA gene sequence. The maximum chitinase production was achieved at 6.52±0.02 U/mL after 72 h of incubation in a medium containing 2% squid pen powder, supplemented with 0.5% sodium nitrate and 2% NaCl, with an initial pH of 7. It was observed that the optimization of cultural conditions resulted in 2.83 times higher chitinase production than an unoptimized medium. The antifungal activity of crude chitinase against phytopathogenic fungi was evaluated by a well-diffusion method. The chitinase of B. paramycoides B26 effectively inhibited the growth of Fusarium solani TISTR 3436 (83.4%) and Penicillium chrysogenum TISTR 3554 (80.12%).
Nasal Carriage of Staphylococcus aureus and Associated Risk Factors among Food Handlers in a Nigerian University
Authors: Akinnola O.O. , Williams A.N. , Oniha M.I. , Ogunleye B.O.
Published: October 2022

Staphylococcal foodborne illness, caused by the ingestion of contaminated foods by induced Staphylococcus aureus enterotoxins, is one of the most recurrent foodborne diseases worldwide. Food handlers working in food-service establishments who carry enterotoxigenic isolates represent a reservoir for potential contamination leading to staphylococcal food intoxication. The aim of this research was to investigate the prevalence of nasal transmission of S. aureus among food handlers in a University community. A total of 100 nasal swab specimens were obtained from the food handlers and analyzed by standard laboratory techniques for isolation and identification. Questionnaires were administered to ascertain the risk determinants associated with nasal carriage of S. aureus. Antibiotic susceptibility testing of the isolates was done by disk diffusion method. Thirty-two food handlers were found to be carriers of S. aureus. Majority were females (63%), and 30% had been certified for food safety and handling. There were however no significant association between the nasal distribution of S. aureus together with established risk factors. Among the isolates, 93.75% were found to be resistant to penicillin, 50% to gentamicin and 50% to oxacillin. These findings indicate the need for training of food handlers on food safety, as well as the knowledge of antibiotic resistance.
Fundamentals and Research Issues on Cloud Computing
Authors: Kargutkar Saloni Mahesh , Borkar Shraddha Manoj
Published: October 2022

Abstract: Access control and data security are now two of the biggest issues with cloud computing. Users can access data from the cloud server through a process known as access control. There are numerous issues that arise while accessing data, including data security, lengthy access times, data loss, overhead, redundant data, etc. An overview of cloud computing basics is given in the first section of this paper. Additionally, this document also covers all cloud computing-related topics. Finally, future development directions for the cloud computing environment have been determined.
Applying the quantum chemical simulation to describe electrical conductivity in silicate-based materials
Authors: Yakovlev Grigorij I. , Khokhriakov Nikolaj V. , Polyanskikh Irina S. , Orban Zoltan , Gumeniuk Alexander N.
Published: October 2022

Introduction. It is confirmed that a dispersion of carbon black when it added to concrete is likely to increase its electrical conductivity. These materials are of great importance for construction for example for civil engineering, transportation and energy industries. In that branches such materials could be used as snow melting systems, protective materials for metal bars, electromagnetically shielded materials. This study is about probable reason of electrically conductive properties in silicate-based material with carbon particles.

Materials and methods. Small molecular fragments which are the parts of modified concrete have been considered to investigate contact areas between carbon particles in silicate based material. Fire Fly has been chosen as software. Exchange-correlation phenomenon has been included by using B3LYP.

Results. An optimum percentage of modifier in mineral binder leads to the formation of an electrically conductive grid made of carbon nanoparticles. Electrical conductivity of material is influenced by contact areas between these nanoparticles. Quantum chemical molecular models of molecular fragments and interactions between these fragments have been made. Also, the impact of these areas on electrical conductivity was estimated.

Conclusions. Quantum chemical molecular models and analysis based on the optimum percentage of the modifier showed that electrical conductivity of the modified concrete depended on an electrons movement along the grid of carbon nanoparticles formed within the mineral matrix. The key role in electrical conductivity of the material plays contact areas between these particles. Electrical conductivity is increasing due to silicate-based components in molecular fragments.
Sobrevivir al cáncer: Narrativas de un grupo de personas a partir de sus experiencias
Authors: Bermúdez Niño Yolanda , Osorio Castaño Jhon Henry
Published: October 2022

Objetivo: Comprender los significados que las personas que sobreviven al cáncer le dan a su vida después de este suceso. Método: Estudio realizado desde el paradigma naturalista con enfoque cualitativo; se aplicó el método biográfico de historia de vida, mediante entrevistas en profundidad a cinco sobrevivientes al cáncer. Se realizó análisis de contenido. Resultados: Emergieron cuatro categorías: el estigma del cáncer en la sobrevida; redes de apoyo para la sobrevida; cuidado de sí en la sobrevida, y trascendencia. Los datos permitieron alcanzar un mayor nivel de comprensión de sus necesidades y cómo están siendo atendidas por los prestadores de servicios de salud en Colombia. Conclusiones: Los sobrevivientes transforman sus cuidados hacia una perspectiva más integral y reinterpretan su nueva vida a partir de la reflexión y la creencia en Dios. En enfermería, los cuidados son orientados a acompañar los principales cambios en el continuo de la sobrevida que se dan desde el momento de la curación.