bluuebunny/crossref_metadata_2025 huggingface dataset:
A Computational Model for Cardiomyocytes Mechano-Electric Stimulation to Enhance Cardiac Tissue Regeneration
Authors: Urdeitx Pau , Doweidar Mohamed H.
Published: October 2020

Electrical and mechanical stimulations play a key role in cell biological processes, being essential in processes such as cardiac cell maturation, proliferation, migration, alignment, attachment, and organization of the contractile machinery. However, the mechanisms that trigger these processes are still elusive. The coupling of mechanical and electrical stimuli makes it difficult to abstract conclusions. In this sense, computational models can establish parametric assays with a low economic and time cost to determine the optimal conditions of in-vitro experiments. Here, a computational model has been developed, using the finite element method, to study cardiac cell maturation, proliferation, migration, alignment, and organization in 3D matrices, under mechano-electric stimulation. Different types of electric fields (continuous, pulsating, and alternating) in an intensity range of 50–350 Vm−1, and extracellular matrix with stiffnesses in the range of 10–40 kPa, are studied. In these experiments, the group’s morphology and cell orientation are compared to define the best conditions for cell culture. The obtained results are qualitatively consistent with the bibliography. The electric field orientates the cells and stimulates the formation of elongated groups. Group lengthening is observed when applying higher electric fields in lower stiffness extracellular matrix. Groups with higher aspect ratios can be obtained by electrical stimulation, with better results for alternating electric fields.
Solving the Boundary Value Problems for Differential Equations with Fractional Derivatives by the Method of Separation of Variables
Authors: Aleroev Temirkhan
Published: October 2020

This paper is devoted to solving boundary value problems for differential equations with fractional derivatives by the Fourier method. The necessary information is given (in particular, theorems on the completeness of the eigenfunctions and associated functions, multiplicity of eigenvalues, and questions of the localization of root functions and eigenvalues are discussed) from the spectral theory of non-self-adjoint operators generated by differential equations with fractional derivatives and boundary conditions of the Sturm–Liouville type, obtained by the author during implementation of the method of separation of variables (Fourier). Solutions of boundary value problems for a fractional diffusion equation and wave equation with a fractional derivative are presented with respect to a spatial variable.
Effectiveness of Streptococcus Pneumoniae Urinary Antigen Testing in Decreasing Mortality of COVID-19 Co-Infected Patients: A Clinical Investigation
Authors: Desai Antonio , Santonocito Orazio Giuseppe , Caltagirone Giuseppe , Kogan Maria , Ghetti Federica , Donadoni Ilaria , Porro Francesca , Savevski Victor , Poretti Dario , Ciccarelli Michele , Martinelli Boneschi Filippo , Voza Antonio
Published: October 2020

Background and objectives: Streptococcus pneumoniae urinary antigen (u-Ag) testing has recently gained attention in the early diagnosis of severe and critical acute respiratory syndrome coronavirus-2/pneumococcal co-infection. The aim of this study is to assess the effectiveness of Streptococcus pneumoniae u-Ag testing in coronavirus disease 2019 (COVID-19) patients, in order to assess whether pneumococcal co-infection is associated with different mortality rate and hospital stay in these patients. Materials and Methods: Charts, protocols, mortality, and hospitalization data of a consecutive series of COVID-19 patients admitted to a tertiary hospital in northern Italy during COVID-19 outbreak were retrospectively reviewed. All patients underwent Streptococcus pneumoniae u-Ag testing to detect an underlying pneumococcal co-infection. Covid19+/u-Ag+ and Covid19+/u-Ag- patients were compared in terms of overall survival and length of hospital stay using chi-square test and survival analysis. Results: Out of 575 patients with documented pneumonia, 13% screened positive for the u-Ag test. All u-Ag+ patients underwent treatment with Ceftriaxone and Azithromycin or Levofloxacin. Lopinavir/Ritonavir or Darunavir/Cobicistat were added in 44 patients, and hydroxychloroquine and low-molecular-weight heparin (LMWH) in 47 and 33 patients, respectively. All u-Ag+ patients were hospitalized. Mortality was 15.4% and 25.9% in u-Ag+ and u-Ag- patients, respectively (p = 0.09). Survival analysis showed a better prognosis, albeit not significant, in u-Ag+ patients. Median hospital stay did not differ among groups (10 vs. 9 days, p = 0.71). Conclusions: The routine use of Streptococcus pneumoniae u-Ag testing helped to better target antibiotic therapy with a final trend of reduction in mortality of u-Ag+ COVID-19 patients having a concomitant pneumococcal infection. Randomized trials on larger cohorts are necessary in order to draw definitive conclusion.
Cu(I/II) Metal–Organic Frameworks Incorporated Nanofiltration Membranes for Organic Solvent Separation
Authors: Upadhyaya Lakshmeesha , Chiao Yu-Hsuan , Wickramasinghe S. Ranil , Qian Xianghong
Published: October 2020

Copper-based metal–organic frameworks (MOFs) with different oxidation states and near-uniform particle sizes have been successfully synthesized. Mixed-matrix polyimide membranes incorporating 0.1–7 wt% of Cu(II) benzene-1,2,5-tricarboxylic acid (Cu(II)BTC), Cu(I/II)BTC and Cu(I) 1,2-ethanedisulfonic acid (EDS) (Cu(I)EDS) MOFs were fabricated via non-solvent-induced phase inversion process. These membranes are found to be solvent resistant and mechanically stable. Liquid phase nanofiltration experiments were performed to separate toluene from n-heptane at room temperature. These membranes demonstrate preferential adsorption and permeation of the aromatic toluene over aliphatic n-heptane. The amount of MOF particles incorporated, the oxidation state of the Cu ion and membrane, and barrier layer thickness have a significant impact on the separation factor. Toluene/heptane separation factor at 1.47, 1.67 and 1.79 can be obtained for membranes incorporating 7 wt% Cu(II)BTC, Cu(I/II)BTC and Cu(I)EDS respectively at room temperature.
Revealing Plasma Membrane Nano-Domains with Diffusion Analysis Methods
Authors: Kure Jakob L. , Andersen Camilla B. , Mortensen Kim I. , Wiseman Paul W. , Arnspang Eva C.
Published: October 2020

Nano-domains are sub-light-diffraction-sized heterogeneous areas in the plasma membrane of cells, which are involved in cell signalling and membrane trafficking. Throughout the last thirty years, these nano-domains have been researched extensively and have been the subject of multiple theories and models: the lipid raft theory, the fence model, and the protein oligomerization theory. Strong evidence exists for all of these, and consequently they were combined into a hierarchal model. Measurements of protein and lipid diffusion coefficients and patterns have been instrumental in plasma membrane research and by extension in nano-domain research. This has led to the development of multiple methodologies that can measure diffusion and confinement parameters including single particle tracking, fluorescence correlation spectroscopy, image correlation spectroscopy and fluorescence recovery after photobleaching. Here we review the performance and strengths of these methods in the context of their use in identification and characterization of plasma membrane nano-domains.
A Novel Non-Equiatomic (W35Ta35Mo15Nb15)95Ni5 Refractory High Entropy Alloy with High Density Fabricated by Powder Metallurgical Process
Authors: Duan Bohua , Yu Yingrui , Liu Xinli , Wang Dezhi , Wu Zhuangzhi
Published: October 2020

A non-equiatomic refractory high entropy alloy (RHEA), (W35Ta35Mo15Nb15)95Ni5 with high density of 14.55 g/cm3 was fabricated by powder metallurgical process of mechanical alloying (MA) and spark plasma sintering (SPS). The mechanical alloying behavior of the metallic powders was studied systematically, and the microstructure and phase composition for both the powders and alloys were analyzed. Results show that the crystal consists of the primary solid solution and marginal oxide inclusion (Nb5.7Ni4Ta2.3O2). In addition, the maximum strength, yield strength and fracture strain are, 2562 MPa, 2128 MPa, 8.16%, respectively.
Detection of Corrosion-Indicating Oxidation Product Colors in Steel Bridges under Varying Illuminations, Shadows, and Wetting Conditions
Authors: Naik Dayakar L. , Sajid Hizb Ullah , Kiran Ravi , Chen Genda
Published: October 2020

Early detection of corrosion in steel bridges is essential for strategizing the mitigation of further corrosion damage. Although various image-based approaches are available in the literature for corrosion detection, most of these approaches are tested on images acquired under uniform natural daylight illuminations i.e., inherent variations in the ambient lighting conditions are ignored. Owing to the fact that varying natural daylight illuminations, shadows, water wetting, and oil wetting are unavoidable in real-world scenarios, it is important to devise a robust technique for corrosion identification. In the current study, four different color spaces namely ‘RGB’, ‘rgb’, ‘HSV’ and ‘CIE La*b*’ along with a multi-layer perceptron (MLP) is configured and trained for detecting corrosion under above-mentioned real-world illumination scenarios. Training (5000 instances) and validation (2064 instances) datasets for this purpose are generated from the images of corroded steel plates acquired in the laboratory under varying illuminations and shadows, respectively. Each combination of color space and an MLP configuration is individually assessed and the best suitable combination that yields the highest ‘Recall’ value is determined. An MLP configuration with a single hidden layer consisting of 4 neurons (1st Hidden Layer (HL)(4N)) in conjunction with ‘rgb’ color space is found to yield the highest ‘Accuracy’ and ‘Recall’ (up to 91% and 82% respectively). The efficacy of the trained MLP to detect corrosion is then demonstrated on the test image database consisting of both lab-generated partially corroded steel plate images and field-generated images of a bridge located in Moorhead (Minnesota). Lab-generated images used for testing are acquired under varying illuminations, shadows, water wetting, and oil wetting conditions. Based on the validation studies, ‘rgb’ color space and an MLP configuration consisting of single hidden layer with 4 neurons (1st HL(4N)) trained on lab-generated corroded plate images identified corrosion in the steel bridge under ambient lighting conditions.
The Effect of Process Parameters on the Microstructure and Mechanical Properties of AW5083 Aluminum Laser Weld Joints
Authors: Vyskoč Maroš , Sahul Miroslav , Dománková Mária , Jurči Peter , Sahul Martin , Vyskočová Monika , Martinkovič Maroš
Published: October 2020

In this article, the effect of process parameters on the microstructure and mechanical properties of AW5083 aluminum alloy weld joints welded by a disk laser were studied. Butt welds were produced using 5087 (AlMg4.5MnZr) filler wire, with a diameter of 1.2 mm, and were protected from the ambient atmosphere by a mixture of argon and 30 vol.% of helium (Aluline He30). The widest weld joint (4.69 mm) and the highest tensile strength (309 MPa) were observed when a 30 L/min shielding gas flow rate was used. Conversely, the narrowest weld joint (4.15 mm) and the lowest tensile strength (160 MPa) were found when no shielding gas was used. The lowest average microhardness (55.4 HV0.1) was recorded when a 30 L/min shielding gas flow rate was used. The highest average microhardness (63.9 HV0.1) was observed when no shielding gas was used. In addition to the intermetallic compounds, β-Al3Mg2 and γ-Al12Mg17, in the inter-dendritic areas of the fusion zone (FZ), Al49Mg32, which has an irregular shape, was recorded. The application of the filler wire, which contains zirconium, resulted in grain refinement in the fusion zone. The protected weld joint was characterized by a ductile fracture in the base material (BM). A brittle fracture of the unshielded weld joint was caused by the presence of Al2O3 particles. The research results show that we achieved the optimal welding parameters, because no cracks and pores were present in the shielded weld metal (WM).
Urine-Based Antigen (Protein) Detection Test for the Diagnosis of Visceral Leishmaniasis
Authors: Campos-Neto Antonio , Abeijon Claudia
Published: October 2020

This review describes and appraises a novel protein-based antigen detection test for visceral leishmaniasis (VL). The test detects in patient’s urine six proteins from Leishmania infantum (chagasi) and Leishmania donovani, the etiological agents of VL. The gold standard test for VL is microscopic observation of the parasites in aspirates from spleen, liver, or bone marrow (and lymph node for dogs). Culture of the parasites or detection of their DNA in these aspirates are also commonly used. Serological tests are available but they cannot distinguish patients with active VL from either healthy subjects exposed to the parasites or from subjects who had a successful VL treatment. An antigen detection test based on the agglutination of anti-leishmania carbohydrates antibody coated latex beads has been described. However, the results obtained with this carbohydrate-based test have been conflicting. Using mass spectrometry, we discovered six L. infantum/L. donovani proteins excreted in the urine of VL patients and used them as markers for the development of a robust mAb-based antigen (protein) detection test. The test is assembled in a multiplexed format to simultaneously detect all six markers. Its initial clinical validation showed a sensitivity of 93% and specificity of 100% for VL diagnosis.
The Microbial Composition in Circumneutral Thermal Springs from Chignahuapan, Puebla, Mexico Reveals the Presence of Particular Sulfur-Oxidizing Bacterial and Viral Communities
Authors: Castelán-Sánchez Hugo Gildardo , Meza-Rodríguez Pablo M. , Carrillo Erika , Ríos-Vázquez David I. , Liñan-Torres Arturo , Batista-García Ramón Alberto , Pérez-Rueda Ernesto , Rojas-Ruíz Norma Elena , Dávila-Ramos Sonia
Published: October 2020

Terrestrial thermal springs are widely distributed globally, and these springs harbor a broad diversity of organisms of biotechnological interest. In Mexico, few studies exploring this kind of environment have been described. In this work, we explore the microbial community in Chignahuapan hot springs, which provides clues to understand these ecosystems’ diversity. We assessed the diversity of the microorganism communities in a hot spring environment with a metagenomic shotgun approach. Besides identifying similarities and differences with other ecosystems, we achieved a systematic comparison against 11 metagenomic samples from diverse localities. The Chignahuapan hot springs show a particular prevalence of sulfur-oxidizing bacteria from the genera Rhodococcus, Thermomonas, Thiomonas, Acinetobacter, Sulfurovum, and Bacillus, highlighting those that are different from other recovered bacterial populations in circumneutral hot springs environments around the world. The co-occurrence analysis of the bacteria and viruses in these environments revealed that within the Rhodococcus, Thiomonas, Thermonas, and Bacillus genera, the Chignahuapan samples have specific species of bacteria with a particular abundance, such as Rhodococcus erytropholis. The viruses in the circumneutral hot springs present bacteriophages within the order Caudovirales (Siphoviridae, Myoviridae, and Podoviridae), but the family of Herelleviridae was the most abundant in Chignahuapan samples. Furthermore, viral auxiliary metabolic genes were identified, many of which contribute mainly to the metabolism of cofactors and vitamins as well as carbohydrate metabolism. Nevertheless, the viruses and bacteria present in the circumneutral environments contribute to the sulfur cycle. This work represents an exhaustive characterization of a community structure in samples collected from hot springs in Mexico and opens opportunities to identify organisms of biotechnological interest.
Comparative Genomics of Pathogenic Clavibacter michiganensis subsp. michiganensis Strains from Chile Reveals Potential Virulence Features for Tomato Plants
Authors: Méndez Valentina , Valenzuela Miryam , Salvà-Serra Francisco , Jaén-Luchoro Daniel , Besoain Ximena , Moore Edward R. B. , Seeger Michael
Published: October 2020

The genus Clavibacter has been associated largely with plant diseases. The aims of this study were to characterize the genomes and the virulence factors of Chilean C. michiganensis subsp. michiganensis strains VL527, MSF322 and OP3, and to define their phylogenomic positions within the species, Clavibacter michiganensis. VL527 and MSF322 genomes possess 3,396,632 and 3,399,199 bp, respectively, with a pCM2-like plasmid in strain VL527, with pCM1- and pCM2-like plasmids in strain MSF322. OP3 genome is composed of a chromosome and three plasmids (including pCM1- and pCM2-like plasmids) of 3,466,104 bp. Genomic analyses confirmed the phylogenetic relationships of the Chilean strains among C.michiganensis subsp. michiganensis and showed their low genomic diversity. Different virulence levels in tomato plants were observable. Phylogenetic analyses of the virulence factors revealed that the pelA1 gene (chp/tomA region)—that grouped Chilean strains in three distinct clusters—and proteases and hydrolases encoding genes, exclusive for each of the Chilean strains, may be involved in these observed virulence levels. Based on genomic similarity (ANIm) analyses, a proposal to combine and reclassify C. michiganensis subsp. phaseoli and subsp. chilensis at the species level, as C. phaseoli sp. nov., as well as to reclassify C. michiganensis subsp. californiensis as the species C. californiensis sp. nov. may be justified.
Why the Anti-Meningococcal B Vaccination during Adolescence Should Be Implemented in Italy: An Overview of Available Evidence
Authors: Boccalini Sara , Zanella Beatrice , Landa Paolo , Amicizia Daniela , Bechini Angela , Innocenti Maddalena , Iovine Mariasilvia , Lecini Elvina , Marchini Francesca , Paolini Diana , Sartor Gino , Zangrillo Francesca , Lai Piero Luigi , Bonanni Paolo , Panatto Donatella
Published: October 2020

Although meningococcal disease has a low incidence in Italy, it is a public health concern owing to its high lethality rate and high frequency of transitory and/or permanent sequelae among survivors. The highest incidence rates are recorded in infants, children and adolescents, and most of the cases are due to Neisseria meningitidis B. In Italy, anti-meningococcal B (anti-MenB) vaccination is free for infants but, despite the considerable disease burden in adolescents, no national recommendation to vaccinate in this age-group is currently available. The aim of this study was to assess the main available scientific evidence to support the Italian health authorities in implementing a program of free anti-MenB vaccination for adolescents. We conducted an overview of the scientific literature on epidemiology, disease burden, immunogenicity and safety of available vaccines, and economic evaluations of vaccination strategies. Each case of invasive meningococcal disease generates a considerable health burden (lethality rate: 9%; up to 60% of patients experience at least one sequela) in terms of impaired quality of life for survivors and high direct and indirect costs (the mean overall cost of acute phase for a single case amounts to about EUR 13,952; the costs for post-acute and the long-term phases may vary widely depending of the type of sequela, reaching an annual cost of about EUR 100,000 in cases of severe neurological damage). Furthermore, vaccination against meningococcus B in adolescence proved cost-effective. The study highlights the need to actively offer the anti-MenB vaccination during adolescence at a national level. This would make it possible to avoid premature deaths and reduce the high costs borne by the National Health Service and by society of supporting survivors who suffer temporary and/or permanent sequelae.
Effects of Implementing the Timed and Targeted Counselling Model on Pregnancy Outcomes and Newborn Survival in Rural Uganda: Protocol for a Quasi-Experimental Study
Authors: Babughirana Geoffrey , Gerards Sanne , Mokori Alex , Musasizi Benon , Isabirye Nathan , Baigereza Isaac Charles , Rukanda Grace , Bussaja Emmanuel , Kremers Stef , Gubbels Jessica
Published: October 2020

Background: Although mortality rates have declined in Uganda over the last decade, maternal mortality is still high at 336 deaths per 100,000 live births, as is infant mortality at 43 deaths per 1000 live births. One in every 19 babies born in Uganda does not live to celebrate their first birthday. Many of these deaths occur within the first 28 days of life, forming the single largest category of death. Promising effects for preventing death are expected from timed and targeted counselling (ttC), an intervention package of key messages and actions that address integrated health and nutrition needs of the mothers and children, barriers and negotiation agreement, to cause sustainable behavioural change at specific timelines in the first 1000 days. Methods: The study has a quasi-experimental design in order to evaluate the implementation and effectiveness of the ttC intervention. Participants are pregnant women who have been registered by village health team (VHT) members and who live in Hoima (intervention region) or Masindi (control region) districts, who will be monitored throughout their pregnancy up to at least six weeks after delivery. A multi-stage sampling technique will be employed to select participants, the study sites being purposively chosen. Sample size is determined using the pregnancy rate from the population estimates, resulting in a total required sample of 1218 (609 each in the intervention and control group). Study instruments that will be used include the Ugandan VHT household register (in which all mothers to be studied will be registered), the ttC register (an additional tool for the study area), and a study questionnaire, to collect data at outcome level. Univariate, bivariate and multivariate analyses will be performed using SPSS to evaluate intervention effects on outcomes (e.g., relationship between pregnancy outcomes and antenatal attendance). In addition, quantitative findings will be triangulated with qualitative data, and collected through interviews and focus group discussions with participants and implementers. Discussion: The proposed study will examine the effectiveness of implementing ttC to improve maternal and child outcomes in Uganda. If ttC is effective, broader implementation of appropriate antenatal services can be advised as essential newborn care improvements. Trial registration: PACTR, PACTR202002812123868. Registered on 25 February 2020.
Physicochemical and Rheological Properties of a Transparent Asphalt Binder Modified with Nano-TiO2
Authors: Rocha Segundo Iran , Landi Salmon , Margaritis Alexandros , Pipintakos Georgios , Freitas Elisabete , Vuye Cedric , Blom Johan , Tytgat Tom , Denys Siegfried , Carneiro Joaquim
Published: October 2020

Transparent binder is used to substitute conventional black asphalt binder and to provide light-colored pavements, whereas nano-TiO2 has the potential to promote photocatalytic and self-cleaning properties. Together, these materials provide multifunction effects and benefits when the pavement is submitted to high solar irradiation. This paper analyzes the physicochemical and rheological properties of a transparent binder modified with 0.5%, 3.0%, 6.0%, and 10.0% nano-TiO2 and compares it to the transparent base binder and conventional and polymer modified binders (PMB) without nano-TiO2. Their penetration, softening point, dynamic viscosity, master curve, black diagram, Linear Amplitude Sweep (LAS), Multiple Stress Creep Recovery (MSCR), and Fourier Transform Infrared Spectroscopy (FTIR) were obtained. The transparent binders (base and modified) seem to be workable considering their viscosity, and exhibited values between the conventional binder and PMB with respect to rutting resistance, penetration, and softening point. They showed similar behavior to the PMB, demonstrating signs of polymer modification. The addition of TiO2 seemed to reduce fatigue life, except for the 0.5% content. Nevertheless, its addition in high contents increased the rutting resistance. The TiO2 modification seems to have little effect on the chemical functional indices. The best percentage of TiO2 was 0.5%, with respect to fatigue, and 10.0% with respect to permanent deformation.
Modification of Silver Nanowire Coatings with Intense Pulsed Ion Beam for Transparent Heaters
Authors: Kaikanov Marat , Amanzhulov Bauyrzhan , Demeuova Gulzat , Akhtanova Gulnur , Bozheyev Farabi , Kemelbay Aidar , Tikhonov Alexander
Published: October 2020

In this report, an improvement of the electrical performance and stability of a silver nanowire (AgNW) transparent conductive coating (TCC) is presented. The TCC stability against oxidation is achieved by coating the AgNWs with a polyvinyl alcohol (PVA) layer. As a result, a UV/ozone treatment has not affected the morphology of the AgNWs network and the PVA protection layer, unlike non-passivated TCC, which showed severe degradation. The irradiation with an intense pulsed ion beam (IPIB) of 200 ns duration and a current density of 30 A/cm2 is used to increase the conductivity of the AgNWs network without degradation of the temperature-resistant PVA coating and decrease in the TCC transparency. Simulations have shown that, although the sample temperature reaches high values, the ultra-high heating and cooling rates, together with local annealing, enable the delicate thermal processing. The developed coatings and irradiation strategies are used to prepare and enhance the performance of AgNW-based transparent heaters. A single irradiation pulse increases the operating temperature of the transparent heater from 92 to 160 °C at a technologically relevant voltage of 12 V. The proposed technique shows a great promise in super-fast, low-temperature annealing of devices with temperature-sensitive components.
Benchmark Investigation of Band-Gap Tunability of Monolayer Semiconductors under Hydrostatic Pressure with Focus-On Antimony
Authors: Dai Xiangyu , Qian Zhengfang , Lin Qiaolu , Chen Le , Wang Renheng , Sun Yiling
Published: October 2020

In this paper, the band-gap tunability of three monolayer semiconductors under hydrostatic pressure was intensively investigated based on first-principle simulations with a focus on monolayer antimony (Sb) as a semiconductor nanomaterial. As the benchmark study, monolayer black phosphorus (BP) and monolayer molybdenum disulfide (MoS2) were also investigated for comparison. Our calculations showed that the band-gap tunability of the monolayer Sb was much more sensitive to hydrostatic pressure than that of the monolayer BP and MoS2. Furthermore, the monolayer Sb was predicted to change from an indirect band-gap semiconductor to a conductor and to transform into a double-layer nanostructure above a critical pressure value ranging from 3 to 5 GPa. This finding opens an opportunity for nanoelectronic, flexible electronics and optoelectronic devices as well as sensors with the capabilities of deep band-gap tunability and semiconductor-to-metal transition by applying mechanical pressure.
High-Yield Production of Water-Soluble MoS2 Quantum Dots for Fe3+ Detection and Cell Imaging
Authors: Xu Benhua , Zhang Zhiqi , Zhang Peng , Wang Li , Yuan Rui , Ju Zhenghua , Liu Weisheng
Published: October 2020

Uniform water-soluble MoS2 quantum dots (WS-MSQDs) were synthesized via a sequential combination of sintering/etching/exfoliation method and solvothermal route. The obtained WS-MSQDs with average size of approximately 3.4 nm exhibited sufficient water solubility and remarkable fluorescence properties. The WS-MSQDs were utilized as a probe for detection of Fe3+ ions with high selectivity and specificity. Furthermore, the WS-MSQDs exhibited high fluorescence stability under different conditions. Finally, the WS-MSQDs were successfully applied for the fluorescence imaging of Fe3+ in living cells, which exhibited practical potential for biomedical applications.
Immobilization of Radioiodine via an Interzeolite Transformation to Iodosodalite
Authors: An Hyejin , Kweon Sungjoon , Park Sanggil , Lee Jaeyoung , Min Hyung-Ki , Park Min Bum
Published: October 2020

We described a technology for immobilizing radioiodine in the sod-cages by the interzeolite transformation of iodine-containing LTA (zeolite A) and FAU (zeolites X and Y) into a sodalite (SOD) structure. The immobilization of iodine in the sod-cage was confirmed using diverse characterization methods including powder XRD, elemental analysis, SEM–EDS, 127I MAS NMR, and I 3d XPS. Although both zeolites A (Na-A) and X (Na-X) were well converted into SOD structure in the presence of NaI and AgI, the iodide anions were fixed in the sod-cages only when NaI was used. The ability to adsorb methyl iodide (CH3I) was evaluated for zeolites A and X in which Na+ and/or Ag+ ions were exchanged, and Ag+ and zeolite X showed better adsorption properties than Na+ and zeolite A, respectively. However, when both CH3I adsorption ability and the successive immobilization of iodine by interzeolite transformation were considered, Na-X was determined to be the best candidate of adsorbent among the studied zeolites. More than 98% of the iodine was successfully immobilized in the sod-cage in the SOD structure by the interconversion of Na-X following CH3I adsorption, although the Na-X zeolite exhibited half the CH3I adsorption capacity of Ag-X.
Self-Rectifying Resistive Switching and Short-Term Memory Characteristics in Pt/HfO2/TaOx/TiN Artificial Synaptic Device
Authors: Ryu Hojeong , Kim Sungjun
Published: October 2020

Here, we propose a Pt/HfO2/TaOx/TiN artificial synaptic device that is an excellent candidate for artificial synapses. First, XPS analysis is conducted to provide the dielectric (HfO2/TaOx/TiN) information deposited by DC sputtering and atomic layer deposition (ALD). The self-rectifying resistive switching characteristics are achieved by the asymmetric device stack, which is an advantage of the current suppression in the crossbar array structure. The results show that the programmed data are lost over time and that the decay rate, which is verified from the retention test, can be adjusted by controlling the compliance current (CC). Based on these properties, we emulate bio-synaptic characteristics, such as short-term plasticity (STP), long-term plasticity (LTP), and paired-pulse facilitation (PPF), in the self-rectifying I–V characteristics of the Pt/HfO2/TaOx/TiN bilayer memristor device. The PPF characteristics are mimicked by replacing the bio-stimulation with the interval time of paired pulse inputs. The typical potentiation and depression are also implemented by optimizing the set and reset pulse. Finally, we demonstrate the natural depression by varying the interval time between pulse inputs.
Optical Limiting of Carbon Nanohorn-Based Aqueous Nanofluids: A Systematic Study
Authors: Sani Elisa , Papi Nicolò , Mercatelli Luca , Barison Simona , Agresti Filippo , Rossi Stefano , Dell’Oro Aldo
Published: October 2020

Nowadays, the use of lasers has become commonplace in everyday life, and laser protection has become an important field of scientific investigation, as well as a security issue. In this context, optical limiters are receiving increasing attention. This work focuses on the identification of the significant parameters affecting optical limiting properties of aqueous suspensions of pristine single-wall carbon nanohorns. The study is carried out on the spectral range, spanning from ultraviolet to near-infrared (355, 532 and 1064 nm). Optical nonlinear properties are systematically investigated as a function of nanohorn morphology, concentration, dimensions of aggregates, sample preparation procedure, nanostructure oxidation and the presence and concentration of surfactants to identify the role of each parameter in the nonlinear optical behavior of colloids. The size and morphology of individual nanoparticles were identified to primarily determine optical limiting. A cluster size effect was also demonstrated, showing more effective optical limiting in larger aggregates. Most importantly, we describe an original approach to identify the dominant nonlinear mechanism. This method requires simple transmittance measurements and a fitting procedure. In our suspensions, nonlinearity was identified to be of electronic origin at a 532 nm wavelength, while at 355 nm, it was found in the generation of bubbles.
The Impact of a Motor Imagery-Based Training Program on Agility, Speed, and Reaction Time in a Sample of Young Tennis Athletes during Ramadan Fasting: Insights and Implications from a Randomized, Controlled Experimental Trial
Authors: Fekih Sofien , Zguira Mohamed Sami , Koubaa Abdessalem , Ghariani Imed , Zguira Hamdi , Bragazzi Nicola Luigi , Jarraya Mohamed
Published: October 2020

The objective of this study was to explore whether a training program incorporating motor imagery could have an effect on physical performance outcomes in terms of agility, speed, and reaction time in a sample of tennis athletes who fasted during the month of Ramadan. Recruited subjects were 27 young male tennis players, randomly allocated to two groups: the imaging training group (n = 13) and a control group (n = 14). The study was designed as a randomized, controlled experimental study. The control group was engaged in watching videos concerning the history of the Olympic Games, whereas the motor imagery group followed a motor imagery-based training program. Physical performance outcomes were assessed during four sessions (one before Ramadan and three during Ramadan) by means of field tests. Our results revealed a drop in all performance outcomes measured in the middle and at the end of Ramadan for both groups (p < 0.01). The effect of the group × time interaction (p < 0.01) was reported for all physical performance outcomes measured for the two groups. This drop in performance was greater for the control group compared to the motor imagery group in the middle and at the end of Ramadan. This study showed that fasting during Ramadan reduced agility, speed, and reaction time performance for tennis players. A motor imagery-based training program could be an effective approach to reduce the effect of fasting during Ramadan and stabilize physical performance outcomes in terms of agility, speed, and reaction time for male tennis players.
Dietary Management, Clinical Status and Outcome of Patients with Citrin Deficiency in the UK
Authors: Pinto Alex , Ashmore Catherine , Batzios Spyros , Daly Anne , Dawson Charlotte , Dixon Marjorie , Evans Sharon , Green Diane , Gribben Joanna , Hunjan Inderdip , Jameson Elisabeth , Newby Camille , Pierre Germaine , Rajwal Sanjay , Robertson Louise , Santra Si , Sharrard Mark , Vara Roshni , White Lucy , Wilcox Gisela , Yilmaz Ozlem , MacDonald Anita
Published: October 2020

Background: Little is known about the optimal dietary treatment for citrin deficiency. Our aim is to describe the management of UK citrin deficiency patients. Methods: A longitudinal retrospective review was performed. Data were collected from medical records on presenting signs and symptoms, dietary management and clinical outcome. Results: data were collected on 32 patients from 21 families. 50% were females (16/32). Median age at diagnosis was 4 y (5 days–35 y) with 12 patients diagnosed in the neonatal period with neonatal intrahepatic cholestasis (NICCD), eight later in childhood (FTTDCD) and 12 by family screening based on index cases from five families. No patient had adult-onset type II citrullinemia. The patient age at the time of data collection was a median of 11 y (1–44 y). 91% (29/32) of patients had normal physical and neurological development, 47% (15/32) experienced recurrent unexplained abdominal pain and 9% (3/32) episodes of hypoglycaemia. Siblings had different phenotypes (5 families had > 1 affected patient). Most patients preferred high protein foods, limiting sugar-containing foods. Only 41% (13/32) were prescribed a low CHO, high protein, high fat diet (restriction varied) and two used medium chain triglyceride (MCT) supplements. No patient was prescribed drug therapy. Twenty-five per cent (8/32) of patients were underweight and 41% (13/32) had height <−1 z-scores. Conclusions: patients presented with various phenotypes, symptoms and suboptimal growth. Symptoms and biochemical markers improved with age, but height remained low in some. More research is necessary to assess the effectiveness of dietary approaches in improving clinical outcomes and symptoms in citrin deficiency.
Impact of the Serum Level of Albumin and Self-Assessed Chewing Ability on Mortality, QOL, and ADLs for Community-Dwelling Older Adults at the Age of 85: A 15 Year Follow up Study
Authors: Nomura Yoshiaki , Kakuta Erika , Okada Ayako , Otsuka Ryoko , Shimada Mieko , Tomizawa Yasuko , Taguchi Chieko , Arikawa Kazumune , Daikoku Hideki , Sato Tamotsu , Hanada Nobuhiro
Published: October 2020

Quality of life (QOL) and mortality are true endpoints of epidemiological or medical research, especially for community-dwelling older adults. Nutritional status and activities of daily living (ADLs) are associated with QOL and mortality. Good oral health status supports a good nutritional status. The aim of this study was to elucidate the complex structure of these important health-related factors. We surveyed 354 healthy older adults at the age of 85. Nutritional status was evaluated by the serum level of albumin. QOL, ADLs, self-assessed chewing ability, serum albumin level, and mortality during the 15 year follow up period were analyzed. Self-assessed chewing ability was associated with QOL and ADLs. Self-assessed chewing ability for slight-hard foods was associated with mortality in men. However, it was not associated with the serum albumin level. The serum albumin level was associated with mortality in women. These results indicate that maintaining good oral function is not enough. Nutritional instruction in accordance with oral function is indispensable for health promotion in older adults. When planning health promotion strategies for older adults, different strategies are needed for men and women.
Whey Protein Drink Ingestion before Breakfast Suppressed Energy Intake at Breakfast and Lunch, but Not during Dinner, and Was Less Suppressed in Healthy Older than Younger Men
Authors: Oberoi Avneet , Giezenaar Caroline , Clames Alina , Bøhler Kristine , Lange Kylie , Horowitz Michael , Jones Karen L. , Chapman Ian , Soenen Stijn
Published: October 2020

Ageing is associated with changes in feeding behavior. We have reported that there is suppression of energy intake three hours after whey protein drink ingestion in young, but not older, men. This study aimed to determine these effects over a time period of 9 h. Fifteen younger (27 ± 1 years, 25.8 ± 0.7 kg/m2) and 15 older (75 ± 2 years, 26.6 ± 0.8 kg/m2) healthy men were studied on three occasions on which they received, in a randomized order, a 30 g/120 kcal, 70 g/280 kcal whey-protein, or control (~2 kcal) drink. Ad-libitum energy intake (sum of breakfast, lunch, and dinner) was suppressed in a protein load responsive fashion (P = 0.001). Suppression was minimal at breakfast, substantial at lunch (~−16%, P = 0.001), no longer present by dinner, and was less in older than younger men (−3 ± 4% vs. −8 ± 4%, P = 0.027). Cumulative protein intake was increased in the younger and older men (+20% and +42%, P < 0.001). Visual analogue scale ratings of fullness were higher and desire to eat and prospective food consumption were lower after protein vs. control, and these effects were smaller in older vs. younger men (interaction effect P < 0.05). These findings support the use of whey-protein drink supplements in older people who aim to increase their protein intake without decreasing their overall energy intake.
Anti-Obesity Effects of Sargassum thunbergii via Downregulation of Adipogenesis Gene and Upregulation of Thermogenic Genes in High-Fat Diet-Induced Obese Mice
Authors: Kang Min-Cheol , Lee Hyo-Geun , Kim Hyun-Soo , Song Kyung-Mo , Chun Yong-Gi , Lee Min Hyeock , Kim Bum-Keun , Jeon You-Jin
Published: October 2020

Obesity is a metabolic disease characterized by an increased risk of type 2 diabetes, hypertension, and cardiovascular disease. We have previously reported that compounds isolated from brown alga, Sargassum thunbergii (ST; Sargassum thunbergii (Mertens ex Roth) Kuntze), inhibit adipogenesis in 3T3-L1 cells. However, the in vivo anti-obesity effects of these compounds have not been previously reported. Therefore, the objective of this study was to determine the effects of ST on weight loss, fat accumulation, as well as risk factors for type 2 diabetes and cardiovascular disease in high-fat diet (HFD)-induced obese mice. ST treatment significantly decreased body weight and fat accumulation in HFD-induced obese mice, while reducing insulin and factors related to cardiovascular diseases (triglyceride and total cholesterol) in serum. ST-induced downregulation of PPARγ in white adipose tissue, and upregulation of the thermogenic genes, UCP-1 and UCP-3, in brown adipose tissue was also observed. In addition, oral administration of ST reduced the occurrence of fatty liver, as well as the amount of white adipose tissue in HFD mice. Cumulatively, these results suggest that ST exerts anti-obesity effects and may serve as a potential anti-obesity therapeutic agent.
ST-CORAbico: A Spatiotemporal Object-Based Bias Correction Method for Storm Prediction Detected by Satellite
Authors: Laverde-Barajas Miguel , Corzo Gerald A. , Poortinga Ate , Chishtie Farrukh , Meechaiya Chinaporn , Jayasinghe Susantha , Towashiraporn Peeranan , Markert Amanda , Saah David , Son Lam Hung , Khem Sothea , Boonya-Aroonnet Surajate , Chaowiwat Winai , Uijlenhoet Remko , Solomatine Dimitri P.
Published: October 2020

Advances in near real-time rainstorm prediction using remote sensing have offered important opportunities for effective disaster management. However, this information is subject to several sources of systematic errors that need to be corrected. Temporal and spatial characteristics of both satellite and in-situ data can be combined to enhance the quality of storm estimates. In this study, we present a spatiotemporal object-based method to bias correct two sources of systematic error in satellites: displacement and volume. The method, Spatiotemporal Contiguous Object-based Rainfall Analysis for Bias Correction (ST-CORAbico), uses the spatiotemporal rainfall analysis ST-CORA incorporated with a multivariate kernel density storm segmentation for describing the main storm event characteristics (duration, spatial extension, volume, maximum intensity, centroid). Displacement and volume are corrected by adjusting the spatiotemporal structure and the intensity distribution, respectively. ST-CORAbico was applied to correct the early version of the Integrated Multi-satellite Retrievals for the Global Precipitation Mission (GPM-IMERG) over the Lower Mekong basin in Thailand during the monsoon season from 2014 to 2017. The performance of ST-CORABico is compared against the Distribution Transformation (DT) and Gamma Quantile Mapping (GQM) probabilistic methods. A total of 120 storm events identified over the study area were classified into short and long-lived storms by using a k-means cluster analysis method. Examples for both storm event types describe the error reduction due to location and magnitude by ST-CORAbico. The results showed that the displacement and magnitude correction made by ST-CORAbico considerably reduced RMSE and bias of GPM-IMERG. In both storm event types, this method showed a lower impact on the spatial correlation of the storm event. In comparison with DT and GQM, ST-CORAbico showed a superior performance, outperforming both approaches. This spatiotemporal bias correction method offers a new approach to enhance the accuracy of satellite-derived information for near real-time estimation of storm events.
Analysis and Modeling of the Complex Dielectric Constant of Bound Water with Application in Soil Microwave Remote Sensing
Authors: Jin Xiao , Yang Wen , Gao Xiaoqing , Li Zhenchao
Published: October 2020

Complex dielectric constant (CDC) of bound water determines the accuracy of the complex dielectric constant of wet soil. According to electrical double-layer structure and dielectric properties, the bound water on clay particle surface is divided into strongly bound water and weakly bound water. Based on this classification, models for the complex dielectric constants of bound water and soil are established taking into consideration factors such as temperature, moisture, texture, and microwave frequency. The results show that the fundamental reason why the complex dielectric constant of bound water is between that of ice and free water is the adsorption force which forms the electrical double-layer structure on the surface of clay particles. Low-concentration cationic solution could exist in free soil water and was found as the reason for the higher salinity and conductivity of free soil water, as compared to the measured soil solution. Results of soil CDC model are in good agreement with measured data across a wide range of microwave frequencies and soil temperature, moisture, and texture. The absolute root mean square error analysis also shows that the soil CDC model in this paper compared to the other models is more accurate.
Compensatory School Effects and Social Capital
Authors: Behtoui Alireza , Strömberg Isabella
Published: October 2020

The aim of this study is to explore whether and how school-based social capital (SSC) may increase or reduce inequalities in the academic achievement and well-being of students from different backgrounds (class, gender, and ethnicity). SSC here refers to those qualities of social relationships and the degree of interconnectedness between students, teachers, and parents that can support the educational attainment and social adjustment of young people. As the results of our ethnographic studies indicate, there is a significant association between SSC and school composition—i.e., the class and ethnic background of students in a school. The association indicates the stratification effect of social capital in schools as a predominant pattern. In a school with students from higher socio-economic backgrounds, we observed more qualified and motivated teachers, an intensive parental involvement, and, consequently, more constructive and friendly relationships among students. In contrast, in a school located in a disadvantaged area, the social relations were quite the reverse. We then found a third category. In a school with children from lower social class backgrounds placed in an immigrant-dense area, highly committed school staff were able to create an emotional closeness and trust between them, the pupils, and their parents. School-based social capital in this context introduced a sense of solidarity and created a pro-educational climate.