bluuebunny/crossref_metadata_2025 huggingface dataset:
Triazine‐Based Polymers as Nanostructured Supports for the Liquid‐Phase Oxidation of Alcohols
Authors: Chan‐Thaw Carine E. , Villa Alberto , Prati Laura , Thomas Arne
Published: November 2010

A covalent triazine framework (CTF) was used as support for palladium nanoparticles (NPs) and Pd/CTF was applied as the catalyst in the selective oxidation of benzyl alcohol. N groups in the CTF appeared more efficient than those created on carbon nanotubes (CNTs) by NH3/high‐temperature treatment in stabilizing Pd NPs against growth during the immobilization step. This assured a high metal dispersion, which led to a highly active and stable catalyst in the alcohol oxidation reaction. Indeed, Pd on the CTF was more stable in recycling than Pd on activated carbon (AC) and on nitrogen‐doped CNTs, particularly avoiding leaching of Pd NPs. Moreover, Pd on the CTF was less sensitive than Pd on AC to the decrease of reactant concentration. This in turn led to a higher selectivity to benzaldehyde (98 %) with a considerable activity (turnover frequency 1453 h−1).
A Minimalist NMR Approach for the Structural Revision of Mucoxin
Authors: Yan Jun , Garzan Atefeh , Narayan Radha S. , Vasileiou Chrysoula , Borhan Babak
Published: November 2010

In an attempt to revise the structural assignment of mucoxin, and faced with 64 diastereomeric possibilities, we resorted to the synthesis of truncated structures that contained the core stereochemical sites. Twelve stereochemical analogues were synthesized, their 1H and 13C NMR spectra were analyzed and four recurring stereochemical trends were distilled from the data. Applying the observed trends to the diastereomeric population pared the possible choices for the correct structure of mucoxin from 64 to 4. Synthesis of these analogues led to the identification of the correct structure of mucoxin.
ChemInform Abstract: Electrical Transport Properties of F‐Doped LaFeAsO Oxypnictide.
Authors: Zhao Li‐Dong , Berardan David , Dragoe Nita
Published: November 2010

LaFeAsO1‐xFx (x = 0, 0.075, 0.15, 0.225) is synthesized by solid state reaction of LaAs, Fe2O3, FeF2, and Fe powders (1150 °C, 50 h) and characterized by XRD, electrical resistivity, and Seebeck coefficient measurements.
ChemInform Abstract: Room Temperature Magnetic and Magnetocaloric Properties of La0.67Ba0.33Mn0.98Ti0.02 O3 Perovskite.
Authors: Oumezzine Ma. , Zemni S. , Pena O.
Published: November 2010

The title compound is prepared by solid state reaction at 1400 °C and characterized by powder XRD, SEM, and magnetic measurements.
ChemInform Abstract: Enhanced Photocatalytic Activity of Mo—{001}TiO2 Core—Shell Nanoparticles under Visible Light.
Authors: Liu Xianguo , Geng Dianyu , Wang Xiaolei , Ma Song , Wang Han , Li Da , Li Baiqing , Liu Wei , Zhang Zhidong
Published: November 2010

The title nanoparticles are prepared by an arc‐discharge technique from Mo and Ti flakes and characterized by powder XRD, TEM, XPS, and UV/VIS spectroscopy.
ChemInform Abstract: Alkali‐Stabilized Pt‐OHx Species Catalyze Low‐Temperature Water‐Gas Shift Reactions.
Authors: Pierre Danny , et al. et al.
Published: November 2010

A dramatic enhancement of the catalytic activity of Pt‐Al2O3 and Pt‐SiO2 for the low‐temperature (about 100 °C) water‐gas shift reaction occurs by addition of Na+ or K+ ions.
ChemInform Abstract: A Facile Construction of Bi‐ or Tricyclic Skeletons by Nickel‐Catalyzed Stereoselective Cyclization of Alkynylcycloalkanone.
Authors: Saito Nozomi , Sugimura Yasuyuki , Sato Yoshihiro
Published: November 2010

The conversion proceeds as a syn‐selective cyclization and the exocyclic alkene part has exclusively the (E) configuration.
ChemInform Abstract: Facile Benzo‐Ring Construction via Palladium‐Catalyzed Functionalization of Unactivated sp3 C—H Bonds under Mild Reaction Conditions.
Authors: Feng Yiqing , Wang Yuji , Landgraf Bradley , Liu Shi , Chen Gong
Published: November 2010

Generally, good yields are obtained for a broad scope of substrates and the reaction is tolerant to air and moisture.
ChemInform Abstract: Broensted Acid Mediated Nazarov Cyclization of Vinylallenes.
Authors: Wu Yen‐Ku , West F. G.
Published: November 2010

In the presence of TFA vinylsilyloxyallenes, generated from siloxy enynes, smoothly undergo Nazarov cyclization to afford cyclopentenone and/or alkylidenecyclopentanone derivatives.
ChemInform Abstract: An Intermolecular Hydroamination of Allenamides with Arylamines Catalyzed by Cationic Au(I) Salts.
Authors: Hill Anthony W. , Elsegood Mark R. J. , Kimber Marc C.
Published: November 2010

It allows a facile, efficient, and selective access to allylamino (E)‐enamides as useful synthons.
ChemInform Abstract: An Expeditious Copper‐Catalyzed Access to 3‐Aminoquinolinones, 3‐Aminocoumarins and Anilines Using Sodium Azide.
Authors: Messaoudi Samir , Brion Jean‐Daniel , Alami Mouad
Published: November 2010

A direct C(sp2)—NH2 bond formation is achieved by Cu(0)—pipecolinic acid—ascorbic acid‐catalyzed reaction of 3‐bromoquinolinones (I), (III), 3‐bromocoumarins (V) and (het)aryl halides (IX) with sodium azide.
ChemInform Abstract: Fluorocyanation of Enamines.
Authors: Dilman Alexander D. , Belyakov Pavel A. , Struchkova Marina I. , Arkhipov Dmitry E. , Korlyukov Alexander A. , Tartakovsky Vladimir A.
Published: November 2010

First examples are reported.
ChemInform Abstract: Iridium‐Catalyzed C—H Activation versus Directed ortho‐Metalation: Complementary Borylation of Aromatics and Heteroaromatics.
Authors: Hartmann Eduard , Kuegel Wolfgang , Parisienne‐La Salle Jean‐Christophe , Batsanov Andrei S. , Marder Todd B. , Snieckus Victor
Published: November 2010

Ir‐catalyzed borylation reactions are achieved on a variety of aryl and pyridyl amide and carbamate substrates.
ChemInform Abstract: Cobalt‐Catalyzed Benzylzincation of Alkynes.
Authors: Murakami Kei , Yorimitsu Hideki , Oshima Koichiro
Published: November 2010

The title reaction proceeds smoothly at ambient temperature to give tri‐ and tetrasubstituted benzylated alkenes with high regio‐ (regioisomeric ratio 90:1 to <99:1) and stereoselectivities (E:Z up to <99:1).
ChemInform Abstract: Asymmetric Conjugate Addition of Nitromethane to Enones Catalyzed by Chiral N,N′‐Dioxide—Scandium(III) Complexes.
Authors: Wang Liwei , Zhang Qi , Zhou Xin , Liu Xiaohua , Lin Lili , Qin Bo , Feng Xiaoming
Published: November 2010

A simple to handle and highly efficient N,N′‐dioxide scandium(III) catalyst is developed for the asymmetric conjugate addition of nitromethane to chalcone analogues.
ChemInform Abstract: Remarkably Effective Phosphanes Simply with a PPh2 Moiety: Application to Pd‐Catalyzed Cross‐Coupling Reactions for Tetra‐ortho‐Substituted Biaryl Syntheses.
Authors: So Chau Ming , Chow Wing Kin , Choy Pui Ying , Lau Chak Po , Kwong Fuk Yee
Published: November 2010

A new set of triarylphosphane ligands is prepared.
ChemInform Abstract: Gold‐Catalyzed Synthesis of Bicyclo[3.2.0]heptenes via a Formal [3 + 2]/[2 + 2]‐Annulation of Allylsilane with 4‐Methoxybut‐2‐yn‐1‐ols.
Authors: Yang Chun‐Yao , Wang Chiou‐Dong , Tian Shu‐Fan , Liu Rai‐Shung
Published: November 2010

The novel title reaction provides access to a variety of highly strained bicyclo[3.2.0]heptenes in high yields and diastereoselectivities.
ChemInform Abstract: An Efficient Electrochemical Method for the Paired Synthesis of Carbonyl Compounds and Homoallylic Alcohols in a Simple Home‐Made Cell
Authors: Zhang Li , Zha Zhenggen , Wang Zhiyong
Published: November 2010

Electrochemical anodic oxidation of alcohols to carbonyl compounds followed by electrochemical cathodic allylation affords the homoallyl alcohols in good yields.
ChemInform Abstract: Asymmetric Aza‐Morita—Baylis—Hillman Reactions of Alkyl Vinyl Ketones with N‐Protected Imines or in situ Generated N‐Protected Imines.
Authors: Guan Xiao‐Yang , Wei Yin , Shi Min
Published: November 2010

Facile and direct routes to enantioselective aza‐Morita—Baylis—Hillman adducts by the reactions of alkyl vinyl ketones with N‐protected imines and α‐amido sulfones, respectively, is developed.
ChemInform Abstract: Aqueous Extract of the Pericarp of Sapindus trifoliatus Fruits: A Novel “Green” Catalyst for the Aldimine Synthesis.
Authors: Pore Santosh , Rahsinkar Gajanan , Mote Kavita , Salunkhe Rajeshri
Published: November 2010

The catalytic activity of the Sapindus trifoliatus fruit extract results from the presence of saponins, which have a common pentacyclic tripernoid skeleton substituted with different carbohydrate side chains.
ChemInform Abstract: Unusual Anion Effects in the Iron‐Catalyzed Formation of 3‐Hydroxyacrylates from Aromatic Aldehydes and Ethyl Diazoacetate.
Authors: Alves Luis Goncalo , Dazinger Georg , Veiros Luis F. , Kirchner Karl
Published: November 2010

Iron trans‐dicarbonyl pincer‐type complexes are shown to catalyze the coupling of aromatic aldehydes with ethyl diazoacetate to give the products (III) or (V) resulting from an intermediate aryl‐shift and the direct coupling products (VI).
ChemInform Abstract: Decarboxylative Acylation of Arenes with α‐Oxocarboxylic Acids via Palladium‐Catalyzed C—H Activation.
Authors: Li Mingzong , Ge Haibo
Published: November 2010

Cross‐coupling of unactivated arenes with aromatic α‐carboxylic acids and an aliphatic analogue (IIi) renders possible a novel access to aryl ketones.
ChemInform Abstract: Acid—Base Organocatalysts for the Aza‐Morita—Baylis—Hillman Reaction of Nitroalkenes.
Authors: Takizawa Shinobu , Horii Atsushi , Sasai Hiroaki
Published: November 2010

New chiral catalysts for the enantioselective coupling of conjugated nitroalkenes and imines are developed.
ChemInform Abstract: Iron‐Catalyzed Regio‐ and Stereoselective Head‐to‐Tail Dimerization of Styrenes.
Authors: Cabrero‐Antonino Jose R. , Leyva‐Perez Antonio , Corma Avelino
Published: November 2010

Cationic Fe(III) salts catalyze the regioselective head‐to‐tail dimerization of styrene derivatives (I), (III) to afford the dimers (II) and (IV), resp., in good yields and excellent E‐selectivity.
ChemInform Abstract: A Novel Process for Selective Ruthenium‐Catalyzed Oxidation of Naphthalenes and Phenols.
Authors: Wienhoefer Gerrit , Schroeder Kristin , Moeller Konstanze , Junge Kathrin , Beller Matthias
Published: November 2010

An improved method is presented for the Ru‐catalyzed hydrogen peroxide oxidation of naphthalenes, naphthols and phenols to the corresponding quinones.
ChemInform Abstract: Rearrangement of 2,3‐Epoxy Alcohol Dimethylthiocarbamate Derivatives. Synthesis of 2,3‐Epithio Alcohol Derivatives under Mild Conditions.
Authors: Kalicki Przemyslaw , Karchier Michal , Michalak Karol , Wicha Jerzy
Published: November 2010

Treatment of 2,3‐epoxy alcohols of type (I), (V), and (VIII) with Cl‐CS‐NMe2 results in formation of the corresponding thiocarbamate derivatives which are unstable and undergo rearrangement to 2,3‐epithio alcohol derivatives at room temperature.
ChemInform Abstract: Tetrathiomolybdate Mediated Rearrangement of Aziridinemethanol Tosylates: A Thia‐aza‐Payne Rearrangement.
Authors: Sureshkumar Devarajulu , Koutha Srinivasamurthy Koutha , Ganesh Venkataraman , Chandrasekaran Srinivasan
Published: November 2010

The rearrangement affords thiiranes.
ChemInform Abstract: N‐Benzyloxymalimide for an Easy Access to 5‐Alkyl‐3‐pyrrolin‐2‐ones: Asymmetric Synthesis of the Mixed Imide Substructure of the Potent Immunosuppressant Microcolin B.
Authors: Ye Zhao‐Bao , Chen Jie , Meng Wei‐Hua , Huang Pei‐Qiang
Published: November 2010

N‐benzyloxymalimide (III) is synthesized as a novel chiral building block.
ChemInform Abstract: Exploiting the Chemistry of Strained Rings: Synthesis of Indoles via Domino Reaction of Aryl Iodides with 2H‐Azirines.
Authors: Candito David A. , Lautens Mark
Published: November 2010

In the case of substrates (IV) the azirine is completely consumed, whereas the aryl iodide is recovered.
ChemInform Abstract: Cationic Pd(II)‐Catalyzed Tandem Reaction of 2‐Arylethynylanilines and Aldehydes: An Efficient Synthesis of Substituted 3‐Hydroxymethyl Indoles.
Authors: Han Xiuling , Lu Xiyan
Published: November 2010

The process works without any redox system.
ChemInform Abstract: Reagent‐Controlled Oxidative Aromatization in Iodocyclization: Switchable Access to Dihydropyrazoles and Pyrazoles.
Authors: Okitsu Takashi , Sato Kana , Wada Akimori
Published: November 2010

The iodo functionality is highly suitable for the introduction of diversity in the product structures.
ChemInform Abstract: Asymmetric 1,3‐Dipolar Cycloaddition Reactions of Azomethine Imines with Acrolein Catalyzed by L‐Proline and Its Derivatives.
Authors: Suga Hiroyuki , Arikawa Tadashi , Itoh Kennosuke , Okumura Yukihisa , Kakehi Akikazu , Shiro Motoo
Published: November 2010

(S)‐Indoline‐2‐carboxylic acid as catalyst shows high exo‐selectivity, while with L‐proline exo‐products are favored due to isomerization of the exo‐ to the endo‐cycloadducts.
ChemInform Abstract: Exploiting the CNC Side Chain in Heterocyclic Rearrangements: Synthesis of 4(5)‐Acylamino‐imidazoles.
Authors: Palumbo Piccionello Antonio , Buscemi Silvestre , Vivona Nicolo , Pace Andrea
Published: November 2010

Imines (V) are prepared via a novel non‐reductive amination.
ChemInform Abstract: C—H Bonds as Ubiquitous Functionality: A General Approach to Complex Arylated Imidazoles via Regioselective Sequential Arylation of All Three C—H Bonds and Regioselective N‐Alkylation Enabled by SEM‐Group Transposition.
Authors: Joo Jung Min , Toure B. Barry , Sames Dalibor
Published: November 2010

Selective formation of 2‐, 4‐, and 5‐monoarylated, 2,5‐, 2,4‐, and 4,5‐diarylated as well as 2,4,5‐triarylated imidazoles is possible.
ChemInform Abstract: 4‐Bis(methylthio)methylene‐2‐phenyloxazol‐5‐one: Versatile Template for Synthesis of 2‐Phenyl‐4,5‐functionalized Oxazoles.
Authors: Misra Nimesh C. , Ila H.
Published: November 2010

A new and simple method affords a number of 2‐phenyl‐4,5‐functionalized oxazoles.
ChemInform Abstract: An Alkynyliodide Cycloaddition Strategy for the Construction of Iodoisoxazoles.
Authors: Crossley James A. , Browne Duncan L.
Published: November 2010

An effective and highly regioselective method to prepare a wide range of 4‐iodoisoxazoles is reported.
ChemInform Abstract: Concise Asymmetric Synthesis of Fully Substituted Isoxazoline‐N‐oxide Through Lewis Base Catalyzed Nitroalkene Activation.
Authors: Zhong Cheng , Gautam Lekh Nath S. , Petersen Jeffrey L. , Akhmedov Novruz G. , Shi Xiaodong
Published: November 2010

The synthesis of optically active isoxazoline N‐oxides is based on the pyrrolidine‐catalyzed reaction of optically active ketone ylide (I) with a nitroalkene and an aldehyde.
ChemInform Abstract: Palladium‐Catalyzed Direct Oxidative Alkenylation of Azoles.
Authors: Miyasaka Mitsuru , Hirano Koji , Satoh Tetsuya , Miura Masahiro
Published: November 2010

In the presence of AgOAc and Pd(OAc)2 thiazoles and oxazoles smoothly react with activated terminal alkynes to afford alkenylated azoles.
ChemInform Abstract: Microwave‐Assisted Synthesis of 1,3,4‐Oxadiazoles Carrying Benzimidazole Moiety and Their Antimicrobial Properties.
Authors: Gowda Janardhana , Khadar A. M. A. , Kalluraya Balakrishna , Kumari Nalilu Suchetha
Published: November 2010

The benzyl‐substituted products (VIII) and their analogues (IX) exhibit antifungal activity.
ChemInform Abstract: Green Synthesis of 5‐Substituted‐1,3,4‐thiadiazole‐2‐thiols as New Potent Nitrification Inhibitors.
Authors: Saha Ajoy , Kumar Rajesh , Kumar Rajendra , Devakumar C.
Published: November 2010

A new one‐pot method is used for the synthesis of acid hydrazides which are further processed in a similar manner to that used in the conventional protocol.
ChemInform Abstract: Gold‐Catalyzed Diastereoselective Cascade Allylation/Enyne Cycloisomerization to Construct Densely Functionalized Oxygen Heterocycles.
Authors: Chen Zili , Zhang Yu‐Xin , Wang Ya‐Hui , Zhu Li‐Li , Liu Heng , Li Xiao‐Xiao , Guo Lin
Published: November 2010

Internal propargylic alcohols provide bicyclic derivatives which are generally formed as a single diastereomer.
ChemInform Abstract: One‐Pot Multicomponent Synthesis and Antimicrobial Evaluation of 2′‐(Indol‐3‐yl)‐2‐oxospiro(indoline‐3,4′‐pyran) Derivatives.
Authors: Nandakumar A. , Thirumurugan Prakasam , Perumal Paramasivan T. , Vembu P. , Ponnuswamy M. N. , Ramesh P.
Published: November 2010

A simple and efficient method for the one‐pot three component synthesis of new spirooxindoles (IV) and (VI) is developed.
ChemInform Abstract: One‐Pot Synthesis of Polyfunctionalized 4H‐Chromenes and Dihydrocoumarins Based on Copper(II) Bromide‐Catalyzed C—C Coupling of Benzylic Alcohols with Ketene Dithioacetals.
Authors: Liang Deqiang , Wang Mang , Bekturhun Bahargul , Xiong Binbin , Liu Qun
Published: November 2010

Title reaction of benzylic alcohols (II) and (VI) with ketene dithioacetals (I) and (VIII) provides access towards 4H‐chromenes (III), (IX) or dihydrocoumarins (IV), (X), resp., depending on the solvent used and on the reaction time.
ChemInform Abstract: Highly Selective Metalations of Pyridines and Related Heterocycles Using New Frustrated Lewis Pairs or tmp‐Zinc and tmp‐Magnesium Bases with BF3·OEt2.
Authors: Jaric Milica , Haag Benjamin A. , Unsinn Andreas , Karaghiosoff Konstantin , Knochel Paul
Published: November 2010

An unexpected metalation method for various functionalized N‐heterocycles is presented using a premixed solution of BF3·OEt2 and MgCl(TMP)·LiCl in a 1:1 ratio.
ChemInform Abstract: Highly Selective Metalations of Pyridines and Related Heterocycles Using New Frustrated Lewis Pairs or tmp‐Zinc and tmp‐Magnesium Bases with BF3·OEt2.
Authors: Jaric Milica , Haag Benjamin A. , Unsinn Andreas , Karaghiosoff Konstantin , Knochel Paul
Published: November 2010

Complementary functionalizations of the heterocycles are achieved by performance of the metalations using different hindered metal amide bases in the presence or absence of BF3·OEt2.
ChemInform Abstract: Conjugate Addition of Lithiated Methyl Pyridines to Enones.
Authors: Taber Douglass F. , Guo Pengfei , Pirnot Michael T.
Published: November 2010

The reaction provides an effective approach to α‐functionalized pyridines such as (III), (V), and (VII).
ChemInform Abstract: Synthesis of Polysubstituted Dihydropyridines by Four‐Component Reactions of Aromatic Aldehydes, Malononitrile, Arylamines, and Acetylenedicarboxylate.
Authors: Sun Jing , Xia Er‐Yan , Wu Qun , Yan Chao‐Guo
Published: November 2010

The reaction with cyanoacetates and cyanoacetamide is also possible yielding dihydropyridines like (VII), (X), and (XII).
ChemInform Abstract: Pre‐Clinical Characterization of Aryloxypyridine Amides as Histamine H3 Receptor Antagonists: Identification of Candidates for Clinical Development.
Authors: Letavic Michael A. , et al. et al.
Published: November 2010

A library of aryloxypyridine amides with different substitution pattern is prepared by conventional procedures.
ChemInform Abstract: Gold(I)‐Catalyzed Domino Reaction of Aziridinyl Alkynes.
Authors: Zhang Zhen , Shi Min
Published: November 2010

The novel gold‐catalyzed title reaction allows the synthesis of a series of tetrahydroisoquinolines such as (III), (V), or (VIII) and (IX).
ChemInform Abstract: Heterocyclization of Functionalized Heterocumulenes with C,N‐, C,O‐, and C,S‐Binucleophiles. Part 11. Synthesis of Dialkyl 2‐Oxo‐3,6‐diaryl‐1,2,3,6‐tetrahydropyrimidine‐4,5‐dicarboxylates by Cyclocondensation of 1‐Chlorobenzyl Isocyanates with Dialkyl Anilinofumarates.
Authors: Vovk M. V. , Kushnir O. V. , Sukach V. A. , Tsymbal I. F.
Published: November 2010

Selective saponification of diester (IIId) succeeds under well‐defined conditions; the hydrolysis leads otherwise to a complex mixture of mono‐ and diacids as well as decarboxylation products.
ChemInform Abstract: Montmorillonite K‐10 Catalyzed Cyclization of N‐Ethoxycarbonyl‐N′‐arylguanidines: Access to Pyrimido[4,5‐c]carbazole and Pyrimido[5,4‐b]indole Derivatives.
Authors: Debray Julien , Zeghida Walid , Baldeyrou Brigitte , Mahieu Christine , Lansiaux Amelie , Demeunynck Martine
Published: November 2010

Two new heterocycles (IV) and (VII) are prepared in three steps using a montmorillonite K‐10‐catalyzed intramolecular Friedel—Crafts cyclization as key reaction.
ChemInform Abstract: Practical Synthesis of Quinoxalinones via Palladium‐Catalyzed Intramolecular N‐Arylations.
Authors: Luo Xuehong , Chenard Etienne , Martens Peter , Cheng Yun‐Xing , Tomaszewski Miroslaw J.
Published: November 2010

An efficient and widely applicable method to prepare biologically important quinoxalinone derivatives is reported.
ChemInform Abstract: 1,2‐Oxazines as Building Blocks for Stereoselective Synthesis: Preparation of Oxygen‐Substituted 1,2‐Oxazines, Either by Alcohol Addition or by Epoxidation, and Subsequent Hydrogenation Leading to 1,2‐Amino Alcohols and Pyrrolidines.
Authors: Zimmer Reinhold , Buchholz Monika , Collas Markus , Angermann Joerg , Homann Kai , Reissig Hans‐Ulrich
Published: November 2010

Different approaches for the synthesis of stereodefined oxygen‐substituted 1,2‐oxazines are presented.
ChemInform Abstract: Synthesis of Small and Large Fused Bicyclic Compounds by Tandem Dienyne Ring‐Closing Metathesis.
Authors: Park Hyeon , Hong You‐Lee , Kim Yongjoo B. , Choi Tae‐Lim
Published: November 2010

Various bicyclic systems are available which contain both small and large ring moieties.
ChemInform Abstract: Neopentylglycolborylation of ortho‐Substituted Aryl Halides Catalyzed by NiCl2‐Based Mixed‐Ligand Systems.
Authors: Moldoveanu Costel , Wilson Daniela A. , Wilson Christopher J. , Leowanawat Pawaret , Resmerita Ana‐Maria , Liu Chi , Rosen Brad M. , Percec Virgil
Published: November 2010

It is found that the systems shown efficiently promote the reactions aryl iodides, bromides, and chlorides.
ChemInform Abstract: Development of Practical Methodologies for the Synthesis of Functionalized Benzoboroxoles.
Authors: Kumar J. Sravan , Bashian Christopher M. , Corsello Michael A. , Jonnalagadda Subash C. , Mereddy Venkatram R.
Published: November 2010

2‐Formylboronic acids (I) undergo Baylis—Hillman reaction with activated olefins (II) or Zn‐mediated reaction with bromides (IV) to yield target compounds (III) and homologues of type (V).
ChemInform Abstract: Stereocontrolled Synthesis of 2‐Substituted‐1,3‐Azasilaheterocycles.
Authors: Hernandez Dacil , Nielsen Lone , Lindsay Karl B. , Lopez‐Garcia M. Angeles , Bjerglund Klaus , Skrydstrup Troels
Published: November 2010

The cyclization precursors are prepared starting from chiral α‐silylsulfinamides [cf.
ChemInform Abstract: Construction of the ABC Ring System of Taxanes via Stereoselective One‐Pot Three‐Component Coupling and Intramolecular Alkylation of a Protected Cyanohydrin Ether.
Authors: Serizawa Takayuki , Miyamoto Shigeru , Fuse Shinichiro , Doi Takayuki , Takahashi Takashi
Published: November 2010

The 1,4‐addition of cyclohexenone (II) to the protected cyanohydrin ether (I) and subsequent addition of formaldehyde (III) to the resulting enolate proceed stereoselectively to afford the AC‐ring system (IV).
ChemInform Abstract: A Novel Aryl‐Hydrazide from the Marine Lichen Lichina pygmaea: Isolation, Synthesis of Derivatives, and Cytotoxicity Assays.
Authors: Roullier Catherine , Chollet‐Krugler Marylene , van de Weghe Pierre , Lohezic‐Le Devehat Francoise , Boustie Joel
Published: November 2010

A new aryl‐hydrazide (S)‐glutamic acid derivative, pygmeine (Ia), is isolated from the methanolic extract of the title marine lichen.
ChemInform Abstract: Synthesis of Tetrahydroisoquinoline Alkaloids via Anodic Cyanation as the Key Step.
Authors: Louafi Fadila , Hurvois Jean‐Pierre , Chibani Aissa , Roisnel Thierry
Published: November 2010

It allows a new route to title alkaloids such as O,O‐dimethylcoclaurine (Va) and norlaudanosine (Vb).
ChemInform Abstract: Benzylisoquinoline Alkaloids from the Tubers of Corydalis ternata and Their Cytotoxicity.
Authors: Kim Ki Hyun , Lee Il Kyun , Piao Cheng Jie , Choi Sang Un , Lee Jei Hyun , Kim Yeong Shik , Lee Kang Ro
Published: November 2010

The new alkaloids epi‐coryximine (Ib), coryternatine A (Ia) together with both enantiomers of (II), named coryternatine B and C, are isolated along with several known alkaloids from the title plant.
ChemInform Abstract: Anibamine, a Natural Product CCR5 Antagonist, as a Novel Lead for the Development of Antiprostate Cancer Agents.
Authors: Zhang Xueping , Haney Kendra M. , Richardson Amanda C. , Wilson Eden , Gewirtz David A. , Ware Joy L. , Zehner Zendra E. , Zhang Yan
Published: November 2010

It is demonstrated that anibamine (I), a recently isolated alkaloid from Aniba species, produces significant inhibition of prostate cancer cell proliferation at micromolar to submicromolar concentrations as well as suppressing adhesion and invasion of the highly metastatic M12 prostate cancer cell line.
ChemInform Abstract: Efficient Synthesis of 2′‐O‐Cyanoethylated Imidazole C‐Ribonucleoside Phosphoramidite: A Practical Building Block for Probing the Catalytic Mechanism of Ribozymes.
Authors: Araki Lisa , Zhao Zheng‐yun , Lilley David M. J. , Harusawa Shinya
Published: November 2010

The synthesis of the stable imidazole C‐ribonucleoside phosphoramidite (I) is achieved from tribenzyl D‐ribose in ten steps with an overall yield of 41%, providing an improvement of yield compared to the unstable 2‐O‐Tbs phosphoramidite.
ChemInform Abstract: Total Syntheses of the Proposed Structures of Cuevaene A.
Authors: Chen Yunxiu , Huang Jianfeng , Liu Bo
Published: November 2010

Both structures (I) are proved to be incorrect.
ChemInform Abstract: Improved Total Synthesis of Racemic Rutamarin.
Authors: Tong Ling , Xiong Ruisheng , Jiang Hong , Jiang Xiangrui , Sun Hongbin , Jiang Hualiang , Shen Jingshan
Published: November 2010

An improved, convenient and cost‐effective synthesis of title compound (V) is developed that does not require any chromatographic purification steps.
ChemInform Abstract: 7′,8′‐Dihydroobolactone, a Trypanocidal α‐Pyrone from the Rainforest Tree Cryptocarya obovata.
Authors: Davis Rohan A. , Demirkiran Ozlem , Sykes Melissa L. , Avery Vicky M. , Suraweera Lekha , Fechner Gregory A. , Quinn Ronald J.
Published: November 2010

Isolation and structure elucidation of the novel secondary metabolite α‐pyrone (I), named 7′,8′‐dihydroobolactone, are reported.
ChemInform Abstract: Preparation and Luminescent Properties of a Novel Red Emitting Phosphor of Ca1‐2xMxIn2O4:xEu3+ (M: Li, Na, K) for White LED Solid‐State Lighting.
Authors: Yan Xiaosong , Li Wanwan , Sun Kang
Published: November 2010

The title phosphors are prepared by solid state reaction of CaCO3, In2O3, Eu2O3, and M2CO3 (M: Li, Na, K) (alumina crucible, 900 °C, 3 h) and characterized by powder XRD and photoluminescence spectroscopy.
ChemInform Abstract: Oxygen Ion Conducting Materials
Authors: Kharton Vladislav V. , Marques Fernando M. B. , Kilner John A. , Atkinson Alan
Published: November 2010

Review: 260 refs.
ChemInform Abstract: Structures and Properties of Heavy Main‐Group Iodometalates
Authors: Wu Li‐Ming , Chen Ling
Published: November 2010

Review: emphasis on iodobismuthates and ‐plumbates; 78 refs.
ChemInform Abstract: Inorganic Non‐Stoichiometric Crystalline Systems and Atomic Ordering
Authors: Smith Mark E.
Published: November 2010

Review: 45 refs.
ChemInform Abstract: Magnetic Nanoparticles: Synthesis, Stabilization, Functionalization, Characterization, and Applications
Authors: Faraji M. , Yamini Y. , Rezaee M.
Published: November 2010

Review: 337 refs.
ChemInform Abstract: Molecular Studies of Model Surfaces of Metals from Single Crystals to Nanoparticles under Catalytic Reaction Conditions. Evolution from Prenatal and Postmortem Studies of Catalysts
Authors: Somorjai Gabor A. , Aliaga Cesar
Published: November 2010

Review: 107 refs.
ChemInform Abstract: Structural, Electronic, Optical and Vibrational Properties of Nanoscale Carbons and Nanowires: A Colloquial Review
Authors: Cole Milton W. , Crespi Vincent H. , Dresselhaus Mildred S. , Dresselhaus Gene , Fischer John E. , Gutierrez Humberto R. , Kojima K. , Mahan Gerald D. , Rao Apparao M. , Sofo Jorge O. , et al. et al.
Published: November 2010

Review: 230 refs.
ChemInform Abstract: Synthetic Nitrogen Fixation with Molybdenum and Tungsten Phosphine Complexes: New Developments
Authors: Stephan Gerald , Tuczek Felix
Published: November 2010

Review: 60 refs.
ChemInform Abstract: The Solvent Effect on the Diels—Alder Reaction in Ionic Liquids: Multiparameter Linear Solvation Energy Relationships and Theoretical Analysis
Authors: Chiappe Cinzia , Malvaldi Marco , Pomelli Christian Silvio
Published: November 2010

Review: 64 refs.
ChemInform Abstract: D‐Erythritol Derivatives: Versatile C‐4 Chiral Building Blocks — Synthesis and Applications
Authors: Mahalingam Sakkarapalayam M. , Satam Vijay S. , Mishra Bijay K. , Pati Hari N.
Published: November 2010

Review: 30 refs.
ChemInform Abstract: Palladium‐Catalyzed Allylic C—H Bond Functionalization of Olefins
Authors: Liu Guosheng , Wu Yichen
Published: November 2010

Review: 36 refs.
ChemInform Abstract: Praziquantel and Schistosomiasis
Authors: Doemling Alexander , Khoury Kareem
Published: November 2010

Review: 70 refs.
ChemInform Abstract: “Ossification” — A Novel Approach for Immobilization of Platinum Group Metal Complex Catalysts: Green and Sustainable Catalyst Design and Preparation
Authors: Sarkar Bibhas R. , Chaudhari Raghunath V.
Published: November 2010

Review: 16 refs.
ChemInform Abstract: Small Organic Molecule Templating Synthesis of Organic—Inorganic Hybrid Materials: Their Nanostructures and Properties
Authors: Yao Hong‐Bin , Gao Min‐Rui , Yu Shu‐Hong
Published: November 2010

Review: 117 refs.
ChemInform Abstract: Molecular Design of Azomethine Complexes
Authors: Garnovskii A. D. , Burlov A. S. , Vasil'chenko I. S. , Garnovskii D. A. , Uraev A. I. , Sennikova E. V.
Published: November 2010

Review: 184 refs.
ChemInform Abstract: Calixarene and Calixresorcarene Glycosides: Their Synthesis and Biological Applications
Authors: Dondoni Alessandro , Marra Alberto
Published: November 2010

Review: 128 refs.
ChemInform Abstract: The Free Tricoordinated Silyl Cation Problem
Authors: Cicak Helena
Published: November 2010

Review: 37 refs.
ChemInform Abstract: Recent Advances in the Synthesis of Ammonium‐Based Rotaxanes
Authors: Thibeault Dominic , Morin Jean‐Francois
Published: November 2010

Review: 83 refs.
ChemInform Abstract: Synthesis of Cyclic Amines by Pericyclic Reactions Involving C=N Units
Authors: Maison W.
Published: November 2010

Review: 234 refs.
ChemInform Abstract: The Study of Linear Solvation Energy Relationship for the Reactivity of Carboxylic Acids with Diazodiphenylmethane in Protic and Aprotic Solvents
Authors: Uscumlic Gordana S. , Nikolic Jasmina B.
Published: November 2010

Review: 48 refs.
ChemInform Abstract: Reviving Artificial Blood: Meeting the Challenge of Dealing with NO Scavenging by Hemoglobin
Authors: Lui Francine E. , Kluger Ronald
Published: November 2010

Review: 61 refs.
ChemInform Abstract: Chemical Looping Technology and Its Fossil Energy Conversion Applications
Authors: Fan Liang‐Shih , Li Fanxing
Published: November 2010

Review: 59 refs.
ChemInform Abstract: Significance of Imidazolopeptide Derivatives
Authors: Kaur A. , Kaur P. , Kaur K. , Kaur R.
Published: November 2010

Review: 7 refs.
ChemInform Abstract: Adsorption of Organic Compounds by Carbon Nanomaterials in Aqueous Phase: Polanyi Theory and Its Application
Authors: Yang Kun , Xing Baoshan
Published: November 2010

Review: 187 refs.
ChemInform Abstract: From Natural to Designer Self‐Assembling Biopolymers, the Structural Characterization of Fibrous Proteins & Peptides Using Fibre Diffraction
Authors: Morris Kyle , Serpell Louise
Published: November 2010

Review: 70 refs.
ChemInform Abstract: Probing Peptide—Nanomaterial Interactions
Authors: Slocik Joseph M. , Naik Rajesh R.
Published: November 2010

Review: 50 refs.
ChemInform Abstract: Detection and Use of Small J Couplings in Solid State NMR Experiments
Authors: Massiot Dominique , Fayon Franck , Deschamps Michael , Cadars Sylvian , Florian Pierre , Montouillout Valerie , Pellerin Nadia , Hiet Julien , Rakhmatullin Aydar , Bessada Catherine
Published: November 2010

Review: 103 refs.
ChemInform Abstract: Lanthanide Enolates as Nuclear Magnetic Resonance Shift Reagents
Authors: Wenzel Thomas J. , Provencher Katelyn A.
Published: November 2010

Review: 207 refs.
Alterations in Corrected QT Interval Following Liver Transplant in Patients With End‐Stage Liver Disease
Authors: Zurick Andrew O. , Spier Bret J. , Teelin Thomas C. , Lorenze Katelin R. , Alberte Cesar , Zacks Steven , Lindstrom Mary J. , Pfau Patrick R. , Selzman Kimberly
Published: November 2010

Background:

Studies have demonstrated that patients with end‐stage liver disease (ESLD) often have a prolonged corrected QT interval (QTc) with variable changes in the QTc post‐transplant. We sought to characterize the prevalence and degree of QTc prolongation in ESLD patients, identify risk factors for QTc prolongation, and assess changes in QTc following transplant.

Hypothesis:

QTc interval is prolonged in ESLD patients pre‐transplant due to a variety of risk factors and shortens following liver transplantation.

Methods:

We conducted a retrospective, multicenter study utilizing 2 large liver‐transplant databases. QTc intervals were calculated utilizing Bazett's formula. The cutoff used for prolonged QTc was 440 milliseconds for men and 460 milliseconds for women.

Results:

There were 269 patients (169 men, 100 women) included in the final analysis. The mean pre‐transplant QTc was prolonged (449.0 ms), whereas the mean post‐transplant QTc shortened and was within normal limits (416.7 ms) (P < 0.0001). QTc shortened after transplant in 87% of patients. QTc normalized in 70% of patients. Age and Model for End‐Stage Liver Disease (MELD) score were not predictive of prolonged QTc at baseline.

Conclusions:

ESLD patients often have a prolonged QTc, which frequently shortens or normalizes after transplant. Screening for prolonged QTc is warranted if medications known to prolong the QTc interval are used in ESLD patients pre‐transplant. MELD score, age, and sex were not predictive of prolonged QTc at baseline. Copyright © 2010 Wiley Periodicals, Inc.

Ms. Lorenze is a student at the University of Wisconsin whose involvement on this project included, but was not limited to, data collection and analysis and manuscript editing. The authors have no funding, financial relationships, or conflicts of interest to disclose.
Long‐Term Results Following Switch From Abciximab to Eptifibatide During Percutaneous Coronary Intervention
Authors: Koutouzis Michael , Lagerqvist Bo , Oldgren Jonas , Åkerblom Axel , Wahlin Magnus , Karlsson Thomas , Albertsson Per , Matejka Göran , Grip Lars
Published: November 2010

Background:

The usage of platelet glycoprotein (GP) IIb/IIIa receptor inhibitors improves the outcome during high‐risk percutaneous coronary interventions (PCI). The aim of this study was to evaluate the long‐term effects after a planned switch from abciximab to eptifibatide during PCI.

Hypothesis:

A switch from the general use of abciximab to eptifibatide as a GP IIb/IIIa in connection with PCI would not have any negative effects on long‐term clinical outcomes.

Methods:

To reduce costs, a general switch from abciximab to eptifibatide was instituted in 2004 in 2 university hospitals in Sweden. All patients treated 6 months before and 6 months after the switch were followed for 30 months. During the study period, 1038 patients underwent PCI and received a GP IIb/IIIa receptor inhibitor, 481 (46%) before the switch (Group A) and 557 (54%) after the switch (Group B). The 2 groups had similar baseline characteristics. The primary endpoint was the composite of death, myocardial infarction, stroke, or new coronary revascularization (percutaneous or surgical); secondary endpoints were the individual components of this composite. A separate analysis was performed on patients treated for ST‐segment elevation myocardial infarction, non–ST‐segment elevation myocardial infarction/unstable angina, and diabetes, respectively. Data were collected from the Swedish Coronary Angiography and Angioplasty Registry.

Results:

There were no differences between the groups in the primary endpoint (29.7% in Group A vs 29.3% in Group B; P = 0.48) or in any of the secondary endpoints.

Conclusions:

A switch from the general usage of abciximab to eptifibatide as a GP IIb/IIIa receptor inhibitor in connection with PCI did not seem to have any negative effects on long‐term clinical outcomes. Copyright © 2008 Wiley Periodicals, Inc.

The authors have no funding, financial relationships, or conflicts of interest to disclose.
Hyponatremia in Acute Decompensated Heart Failure: Mechanisms, Prognosis, and Treatment Options
Authors: Jao Geoffrey T. , Chiong Jun R.
Published: November 2010

Hyponatremia is common and is increasingly recognized as an independent prognostic marker that adversely affects morbidity and mortality in various disease states, including heart failure. In acute decompensated heart failure (ADHF), the degree of hyponatremia often parallels the severity of cardiac dysfunction and is further exacerbated by any reduction in glomerular filtration rate and arginine vasopressin dysregulation. A recent study showed that even modest improvement of hyponatremia may have survival benefits. Although management of hyponatremia in ADHF has traditionally focused on improving cardiac function and fluid restriction, the magnitude of improvement of serum sodium is fairly slow and unpredictable. In this article, we discuss the mechanisms of hyponatremia in ADHF, review its evolving prognostic significance, and evaluate the efficacy of various treatments for hyponatremia, including the recently approved vasopressin receptor antagonists for managing hyponatremia among patients hospitalized for ADHF. Copyright © 2008 Wiley Periodicals, Inc.

Dr. Jun Chiong is a member of the Speaker's Bureau of Otsuka Pharmaceutical company. The authors have no additional funding, financial relationships, or conflicts of interest to disclose.
A novel tumor‐node‐metastasis (TNM) staging system of diffuse malignant peritoneal mesothelioma using outcome analysis of a multi‐institutional database*
Authors: Yan Tristan D. , Deraco Marcello , Elias Dominique , Glehen Olivier , Levine Edward A. , Moran Brendan J. , Morris David L. , Chua Terence C. , Piso Pompiliu , Sugarbaker Paul H. ,   Peritoneal Surface Oncology Group
Published: November 2010

BACKGROUND:

Currently, no tumor‐node‐metastasis (TNM) staging system exists for patients with diffuse malignant peritoneal mesothelioma (DMPM). The primary objective was to formulate a clinicopathological staging system through the identification of significant prognostic parameters.

METHODS:

Eight international institutions with prospectively collected data on patients who underwent cytoreductive surgery and hyperthermic intraperitoneal chemotherapy contributed to the registry. Two hundred ninety‐four patients had complete clinicopathological data and formed the basis of this staging project.

RESULTS:

Peritoneal cancer index (PCI) was categorized into T1 (PCI 1‐10), T2 (PCI 11‐20), T3 (PCI 21‐30), and T4 (PCI 30‐39). Twenty‐two patients had positive lymph nodes (N1) and 12 patients had extra‐abdominal metastases (M1). The survival for patients with T1 (PCI 1‐10) N0 M0 was significantly superior to the other patients. This group of patients is therefore designated as Stage I. The survival of patients with T2 (PCI 11‐20) and T3 (PCI 21‐30), in absence of N1 or M1 disease, was similar. This group of patients was categorized as Stage II. The survival of patients with T4 (PCI 30‐39), N1, and/or M1 was similarly poor. This group of patients was therefore categorized as Stage III. Three prognostic factors were independently associated with survival in the multivariate analysis: histological subtype, completeness of cytoreduction, and the proposed TNM staging. The 5‐year survival associated with Stage I, II, and III disease was 87%, 53%, and 29%, respectively.

CONCLUSIONS:

The proposed TNM staging system resulted in significant stratification of survival by stage when applied to the current multi‐institutional registry data. Cancer 2011. © 2010 American Cancer Society.
DNA methylation predicts recurrence from resected stage III proximal colon cancer
Authors: Ahn Joong Bae , Chung Woon Bok , Maeda Osamu , Shin Sang Joon , Kim Hyun Soo , Chung Hyun Chul , Kim Nam Kyu , Issa Jean‐Pierre J.
Published: November 2010

BACKGROUND:

In colorectal cancer (CRC), DNA methylation anomalies define distinct subgroups termed CpG island methylator phenotype 1 (CIMP1), CIMP2, and CIMP‐negative. The role of this classification in predicting recurrence and disease‐free survival (DFS) in resected stage III CRC was evaluated.

METHODS:

Sporadic cancers from 161 patients were analyzed. Bisulfite pyrosequencing was used to examine the methylation of 2 global DNA methylation markers (LINE‐1, Alu) and 9 loci (MINT1, MINT2, MINT31, P16, hMLH1, P14, SFRP1, SFRP2, and WNT5A). Mutations in BRAF and KRAS were assayed.

RESULTS:

Gene hypermethylation clustered in discrete groups of patients, indicating the presence of CIMP. K‐means clustering analysis identified 3 discrete subgroups: CIMP1 (n = 22, 13.7%), associated with proximal location and BRAF mutations; CIMP2 (n = 40, 24.8%), associated with KRAS mutations; and CIMP‐negative (n = 99, 61.5%), associated with distal location. In proximal CRC, CIMP1 was correlated with a higher recurrence rate (53% for CIMP1, 18% for CIMP2, and 26% for CIMP‐negative) and a worse DFS (P = .015). Also in proximal CRC, LINE‐1 methylation was lower in patients whose cancer recurred compared with those whose cancer did not recur (P = .049). In multivariate analysis, CIMP1 and low LINE1 methylation were independent prognostic factors for DFS in proximal CRC (P = .008 for classification by K‐means clustering analysis; P = .040 for LINE‐1 methylation status).

CONCLUSIONS:

DNA methylation is a useful biomarker of recurrence in resected stage III proximal but not distal CRC. However, as the number of CIMP1 cases was small in distal CRC, further study is required to validate our findings. Cancer 2011. © 2010 American Cancer Society.
The efficacy and safety of bortezomib and dexamethasone as a maintenance therapy in patients with advanced multiple myeloma who are responsive to salvage bortezomib‐containing regimens
Authors: Benevolo Giulia , Larocca Alessandra , Gentile Massimo , Pregno Patrizia , Gay Francesca , Botto Barbara , Frairia Chiara , Evangelista Andrea , Morabito Fortunato , Boccadoro Mario , Vitolo Umberto , Palumbo Antonio
Published: November 2010

BACKGROUND:

Although treatment for multiple myeloma (MM) has considerably improved in the past decade, MM continues to be an incurable hematological malignancy that causes most patients to eventually relapse and die from their illness. Thus, the identification of effective salvage strategies remains a priority.

METHODS:

In this trial, the authors evaluated the safety and efficacy of bortezomib and dexamethasone [V: on days 1 and 15 (1.3 mg/mq); D: on days 1‐2 and 15‐16, every 28‐day cycle until progression (20 mg/d)] as maintenance therapy (MT) in patients with advanced MM who responded to salvage therapy that used a bortezomib‐containing regimen.

RESULTS:

Forty‐nine MM patients were enrolled in this study between October of 2004 and April of 2008. All patients who were included in this study were responsive to a prior salvage therapy with bortezomib and had a measurable disease. The bortezomib and dexamethasone MT improved the quality of responses to complete remission in 4 patients and very good partial response in 3 patients. In addition, 10 patients experienced at least a 50% improvement in their symptoms. The median time to progression (TTP) was 16 months with a progression‐free survival of 61% after 1 year. The overall response after 1 year was 76%, and the cumulative incidence of death due to disease progression, which was adjusted for competitive risk events, was 14%. Non‐dose‐limiting toxicities included neuropathy (predominantly grade 1), herpes zoster reactivation, pneumonia, and gastrointestinal affections (constipation and diarrhea). Three patients developed grade 2 neuropathy, which required a bortezomib dose reduction to 1.0 mg/mq. No grade 3 or 4 toxicities were recorded.

CONCLUSIONS:

The use of bortezomib and dexamethasone as MT in advanced MM was effective and well tolerated. The twice‐monthly bortezomib infusion appeared to reduce the incidence of grade 3 and 4 neuropathies in comparison to similar experiences in other settings. Cancer 2011. © 2010 American Cancer Society.
Progression‐free survival as a predictor of overall survival in metastatic renal cell carcinoma treated with contemporary targeted therapy
Authors: Heng Daniel Y. C. , Xie Wanling , Bjarnason Georg A. , Vaishampayan Ulka , Tan Min‐Han , Knox Jennifer , Donskov Frede , Wood Lori , Kollmannsberger Christian , Rini Brian I. , Choueiri Toni K.
Published: November 2010

BACKGROUND.

The majority of metastatic renal cell carcinoma (mRCC) clinical trials that examined targeted agents used progression‐free survival (PFS) as the primary endpoint. Whether PFS can be used as a predictor of overall survival (OS) is unknown.

METHODS.

Patients from 12 cancer centers who received targeted therapy for mRCC were identified. Landmark analyses for progression at 3 months and 6 months after drug initiation were performed to minimize lead‐time bias. A proportional hazards model was used to assess the utility of PFS for predicting OS.

RESULTS.

In total, 1158 patients were included. The median follow‐up was 30.6 months, the median age was 60 years, and the median Karnofsky performance status was 80%. For the entire cohort, the median PFS was 7.6 months, and the median OS was 19.7 months. In the landmark analysis, the median OS for patients who progressed at 3 months was 7.8 months compared with 23.6 months for patients who did not progress (log‐rank test; P < .0001). Similarly, for patients who progressed at 6 months, the median OS was 8.6 months compared with 26 months for patients who did not progress (P < .0001). Compared with those who did not progress, for the patients who progressed at 3 months and at 6 months, the hazard ratios for death adjusted for adverse prognostic factors were 3.05 (95% confidence interval, 2.42‐3.84) and 2.96 (95% confidence interval, 2.39‐3.67), respectively. Similar results were demonstrated with landmark analyses at 9 months and at 12 months and in the bootstrap validation. Kendall tau rank correlation and a Fleischer model demonstrated a statistically significant dependent correlation.

CONCLUSIONS.

PFS at 3 months and at 6 months predicted OS, and the current results indicated that PFS may be a meaningful intermediate endpoint for OS in patients with mRCC who receive treatment with novel agents. Cancer 2011;. © 2010 American Cancer Society.