bluuebunny/crossref_metadata_2025 huggingface dataset:
Adequate Volume Restitution with Midodrine Versus Albumin in Patients with Refractory Ascites Undergoing Large-Volume Paracentesis: A Comparative Analysis
Authors:   Universidad Autonoma de Guadalajara. Zapopan, Jalisco, Mexico, Martinez Gustavo Bastien , López Donaldo Emiliano Silva ,   Tecnológico de Monterrey Campus Monterrey, Nuevo Léon, Mexico, Ynostroza Sussan Irlanda Méndez ,   Universidad Autonoma de Guadalajara. Zapopan, Jalisco, Mexico., Bautista Miguel Ángel Florán ,   Tecnológico de Monterrey Campus Monterrey, Nuevo Léon, Mexico, Sánchez Verónica Yoseline Campos ,   Universidad Autónoma de Aguascalientes. Aguascalientes, Mexico., Ibarra Ivan Andres Lara ,   Universidad Autónoma de Aguascalientes. Aguascalientes, Mexico.
Published: December 2024

Large-volume paracentesis (LVP) is a cornerstone in the management of refractory ascites in cirrhotic patients, but it is associated with significant hemodynamic complications, including paracentesis-induced circulatory dysfunction (PICD). Current guidelines advocate for the use of albumin to mitigate these risks; however, its high cost and limited availability have prompted the exploration of alternative therapies such as midodrine, an α1-adrenergic agonist with vasoconstrictive properties. This study aims to compare the efficacy and safety of midodrine versus albumin in maintaining hemodynamic stability and preventing PICD post-LVP. We conducted a prospective, randomized trial involving patients with refractory ascites, evaluating hemodynamic parameters, renal function, and clinical outcomes. Our findings suggest that midodrine offers a cost-effective alternative to albumin with comparable efficacy in volume restitution, although certain patient subgroups may benefit more from specific interventions. Further research is warranted to optimize patient selection and treatment protocols.
Estrogen and Memory during the Perimenopause Period: A Critical Review
Authors:   Fielding Graduate University, Williamson Jennifer L.
Published: December 2024

Menopause is an encompassing neuroendocrine aging process, marked by declining sex hormones, particularly estradiol, with significant consequences for cognitive brain function that will affect every woman who lives long enough to enter the phase. This critical review examines recent neuroimaging studies investigating the underlying biological mechanisms of cognitive changes during menopause, focusing on estrogen receptor density in the brain. Advanced neuroimaging techniques, such as 18F-fluoroestradiol (18F-FES) Positron Emission Tomography (PET), have provided novel insights into the distribution and density of estrogen receptors across different menopausal stages. Key findings reveal that estrogen receptor (ER) density in the brain increases progressively over the menopause transition, independent of age and plasma estradiol levels. Notably, higher ER density is associated with poorer memory performance and predicts mood and cognitive symptoms in postmenopausal women. These results suggest a potential compensatory mechanism in response to declining estrogen levels, offering a neurobiological explanation for cognitive changes observed during menopause.
Intestinal Invagination Secondary to Vanek Tumor, A Rare Cause of Intestinal Obstruction in Adults: Case Report
Authors:   Department of General Surgery, Fourth-year Resident, General Hospital No. 3 (I.M.S.S.), Aguascalientes, Aguascalientes, Mexico., Massiel Márquez Lara, , Barrios Domínguez Barrios, ,   Social Service Medical Intern, Directorate of Medical Services of the State Comprehensive Family Development, Aguascalientes, Aguascalientes, Mexico., Javier Águila Andrade, ,   Department of General Surgery, General Surgeron, General Hospital No. 3 (I.M.S.S.), Aguascalientes, Aguascalientes, Mexico., Luis Bizueto Monroy, José ,   Department of General Surgery, General Surgeron, General Hospital No. 3 (I.M.S.S.), Aguascalientes, Aguascalientes, Mexico.
Published: December 2024

Introduction: Mechanical intestinal obstruction is a common surgical condition with a wide range of causes, including intrinsic intestinal problems such as intestinal invagination. This condition is extremely rare in the adult population and is mostly caused by neoplasms. The clinical presentation, although varied, is typically gradual and nonspecific. Among intestinal neoplasms, inflammatory fibroid polyps (IFPs) are very rare, constituting less than 0.1% of gastrointestinal tract polyps.

Case Presentation: We present a 48-year-old female patient who presented with abdominal pain lasting for 1 month, with a 4-month history of constipation. A CT scan showed findings suggestive of pseudo-obstruction secondary to intestinal invagination. After an emergency laparotomy, histopathological analysis reported a Vanek tumor in the terminal ileum.

Discussion: Intestinal intussusception in adults is a rare condition, often caused by benign tumors that act as lead points. Inflammatory fibroid polyps (IFP), commonly located in the ileum, are such tumors. The symptoms are typically nonspecific, making early diagnosis challenging. In the presented case, a laparotomy was performed to address the obstruction and resect the tumor, which was histologically confirmed as an IFP. This case highlights the importance of considering these tumors in the differential diagnosis of adult intussusception and the need for timely surgical intervention.

Conclusion: IFPs should be considered in the differential diagnosis of adult intussusception, especially in cases of chronic, non-specific symptoms and intestinal obstruction.
Exploring the Role of Dipeptidyl Peptidase-4 (DPP-4) Inhibitors in the Management of Cardiogenic Shock: Pathophysiological Insights and Therapeutic Potential
Authors:   Tecnológico de Monterrey Campus Monterrey, Nuevo Léon, Mexico, López Donaldo Emiliano Silva , Hernández Eduardo Antonio Vera ,   Universidad Cuauhtémoc Plantel Aguascalientes. Aguascalientes, México., Mireles Angélica Ahtziri Esquivel ,   Universidad Autónoma de Zacatecas. Zacatecas, López Oswaldo Alfredo Rangel ,   Universidad Cuauhtémoc Plantel Aguascalientes. Aguascalientes, México., Castillo Celerino Luis Hiram Morán ,   Universidad Cuauhtémoc Plantel Aguascalientes. Aguascalientes, México., Esparza Sandra Eugenia Herrera ,   Universidad Cuauhtémoc Plantel Aguascalientes. Aguascalientes, México.
Published: December 2024

Cardiogenic shock remains a critical condition characterized by profound myocardial dysfunction leading to end-organ hypoperfusion and high mortality rates despite advances in supportive therapies. While traditional management focuses on inotropes, vasopressors, and mechanical circulatory support, recent evidence suggests that metabolic modulation could provide additional benefits. Dipeptidyl peptidase-4 (DPP-4) inhibitors, primarily used in type 2 diabetes mellitus, have demonstrated cardioprotective effects through pleiotropic mechanisms, including anti-inflammatory, endothelial-protective, and metabolic-modulating actions. This review examines the potential utility of DPP-4 inhibitors in the context of cardiogenic shock, emphasizing their mechanisms of action, experimental and clinical data, and the feasibility of integrating these agents into the current therapeutic paradigm. We highlight gaps in knowledge and propose directions for future research to determine the clinical efficacy of DPP-4 inhibitors in this high-risk population.
The Role of Artificial Intelligence and Machine Learning in Decision-Making in the ICU
Authors:   Senior Consultant, Critical Care Medicine Department: Intensive Care Medicine, Sir Hurkisondas Nurrotumdas Reliance Foundation Hospital and Research Centre, Kargirwar Dr Ketan , Dange Dr Anjali ,   Clinical Assistant, Department: Internal Medicine, Sir Hurkisondas Nurrotumdas Reliance Foundation Hospital and Research Centre, Pandit Dr Rahul ,   Chair, Critical Care Medicine Department: Intensive Care Medicine, Sir Hurkisondas Nurrotumdas Reliance Foundation Hospital and Research Centre
Published: December 2024

Artificial Intelligence (AI) and Machine Learning (ML) are revolutionizing critical care. In the Intensive Care Unit (ICU), timely and accurate decisions are crucial. AI and ML can enhance decision-making by predicting adverse events, personalizing treatment plans, and improving diagnostic accuracy. Early warning systems, powered by AI, can detect conditions like sepsis and acute respiratory distress syndrome early on. AI-driven decision support systems provide real-time recommendations, optimizing resource allocation and ensuring adherence to best practices.

While AI offers significant benefits, challenges like data privacy, bias, and ethical considerations must be addressed. Ensuring transparency, accountability, and fairness in AI algorithms is essential.

The future of AI in the ICU is promising. Advancements in AI and ML, coupled with collaborative human-AI approaches can further improve patient outcomes. By addressing ethical concerns and fostering responsible AI development, healthcare providers can harness the power of AI to optimize critical care.
Demographic Characteristics Associated with Bilateral Renal Lithiasis
Authors:   Universidad Autónoma de Guadalajara, Flores Daniel García , Espinoza José Armando Pérez ,   Instituto Mexicano del Seguro Social
Published: December 2024

Bilateral renal lithiasis, characterized by the presence of kidney stones in both kidneys, poses significant clinical challenges. This condition is associated with a higher risk of chronic kidney disease (CKD), kidney tubular injury, metabolic disorders, and diminished health-related quality of life (HRQoL). Patients with bilateral stones experience more frequent stone events, a younger age of onset, and a higher prevalence of metabolic abnormalities such as elevated blood pressure and serum glucose. Demographic factors, including socioeconomic status, race, age, and gender, further influence the impact of this condition, with nonwhite ethnicities and lower-income groups reporting worse HRQoL. Untreated bilateral renal lithiasis significantly increases the risk of CKD progression, while advanced surgical approaches like bilateral synchronous percutaneous nephrolithotomy offer effective and safe management options. Addressing this condition requires a multifaceted approach that considers both medical interventions and social determinants of health.
Long-Term Follow-Up in Patients with Modified Fontan: Assessing Outcomes, Complications, and Management Strategies for Single-Ventricle Survivors
Authors:   Tecnológico de Monterrey Campus Monterrey, Nuevo Léon, Mexico, López Donaldo Emiliano Silva , López Fernanda Reyes ,   Universidad Autonoma de Aguascalientes. Aguascalientes, México, Badillo Kenia Itzel Muñoz ,   Universidad Autonoma de Aguascalientes. Aguascalientes, México, Narváez José Anthar Ávalos ,   Universidad Autonoma de Aguascalientes. Aguascalientes, México, Loera Luis Pablo Durán ,   Universidad Autonoma de Aguascalientes. Aguascalientes, México, Valdes Erick Ernesto Regalado ,   Universidad Autonoma de Aguascalientes. Aguascalientes, México
Published: December 2024

The modified Fontan procedure, a pivotal surgical intervention for patients with single-ventricle congenital heart defects, has drastically improved survival rates and quality of life for individuals who would otherwise face limited options. Despite these advancements, patients with modified Fontan physiology experience a unique set of hemodynamic challenges that require vigilant long-term follow-up. The Fontan circulation, characterized by passive venous return to the pulmonary arteries without a ventricular pump, predisposes patients to a variety of late complications, including Fontan-associated liver disease (FALD), arrhythmias, protein-losing enteropathy (PLE), thromboembolic events, and systemic venous hypertension. This review aims to evaluate the outcomes and long-term complications associated with modified Fontan patients, emphasizing the importance of early detection, multidisciplinary care, and individualized management strategies. The article explores current evidence on surveillance protocols, pharmacological treatments, and surgical interventions, as well as emerging therapeutic options like Fontan conversion, catheter-based therapies, and heart transplantation. This comprehensive analysis seeks to provide healthcare providers with a roadmap for optimizing care and improving the long-term prognosis of these patients.
Surgical Management of Budd-Chiari Syndrome: A Comprehensive Review of Techniques and Outcomes
Authors:   U.M.A.E. Hospital de especialidades C.M.N. GRAL. "Manuel Avila Camacho" Instituto Mexicano del Seguro Social Puebla, México., Avendaño Ana Laura Esmeralda Muñoz , Cervantes Yafte Soto ,   Instituto Mexicano del Seguro Social Hospital General Regional 2 El Marqués. Querétaro, México., Moreno Michelle Macias ,   Universidad de las Américas Puebla. Puebla. México.
Published: December 2024

Budd-Chiari syndrome (BCS) is a rare but life-threatening condition characterized by obstruction of hepatic venous outflow, leading to hepatic congestion, portal hypertension, and potential liver failure. While pharmacological and interventional approaches play a significant role in its management, surgical intervention remains a cornerstone for cases refractory to less invasive measures. This review explores the surgical strategies employed in the treatment of BCS, ranging from shunting procedures, such as portosystemic shunts, to advanced techniques like liver transplantation. Emphasis is placed on patient selection criteria, perioperative considerations, and long-term outcomes. Additionally, the evolving role of minimally invasive and hybrid approaches in this domain is analyzed. By synthesizing current evidence, this article aims to guide clinicians in optimizing the surgical care of BCS patients.
Cardiac Amyloidosis: A Comprehensive Review of Pathophysiology, Diagnosis, and Emerging Therapeutic Strategies
Authors:   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico. Servicio de Medicina interna., Chávez Juan Felipe Garibay , Guerrero Adan Samael Martínez ,   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico. Servicio de Medicina interna., Mancillas Mario Hernandez ,   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico, Pérez Héctor Cisneros ,   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico., Duarte Rafael Delgado ,   Hospital del Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado Zacatecas. Zacatecas, Zacatecas, Mexico.
Published: December 2024

Cardiac amyloidosis (CA) is a life-threatening, infiltrative cardiomyopathy characterized by the extracellular deposition of amyloid fibrils within myocardial tissue. This pathological process results in progressive diastolic and, ultimately, systolic dysfunction, leading to heart failure and associated morbidities. CA predominantly arises from two amyloid types: immunoglobulin light chain (AL) amyloidosis and transthyretin amyloidosis (ATTR), which can be either hereditary (ATTRv) or wild-type (ATTRwt). Given the heterogeneity of clinical manifestations, early diagnosis remains challenging but critical for optimizing patient outcomes. Advanced imaging modalities, including cardiac magnetic resonance (CMR) and bone scintigraphy, alongside tissue biopsy and genetic testing, have revolutionized diagnostic accuracy. Recent advances in targeted therapies, particularly transthyretin stabilizers and RNA-based therapies, are reshaping the clinical landscape. This review aims to elucidate the complex pathophysiology of cardiac amyloidosis, discuss the latest diagnostic criteria and techniques, and evaluate current and emerging therapeutic approaches. Through a comprehensive analysis, this article underscores the importance of early recognition and multidisciplinary management to improve prognosis and quality of life in affected individuals.
An Updated View of Breast Reconstruction
Authors:   Residente de Cirugía Plástica y Recosntructiva, IMSS Hospital de Traumatología y Ortopedia, Caprielova Yuri Jiménez , Palomares Kenia Selene Avilés ,   Residente de Cirugía Plástica y Recosntructiva, IMSS Hospital de Traumatología y Ortopedia, Torón Dr. Juan Carlos Hernández ,   Títular y Adscrito de cirugía plástica y reconstructiva, IMSS Hospital de Traumatología y Ortopedia
Published: December 2024

Breast reconstruction is a cornerstone of post-mastectomy care, aiming to restore the breast’s form and appearance while enhancing patients’ psychosocial well-being. The procedure can be performed using implant-based or autologous tissue techniques, each tailored to the patient’s medical profile, treatment plan, and preferences. Implant-based reconstruction, involving saline or silicone implants, offers shorter recovery times and is often preferred in patients without planned postmastectomy radiation therapy. Autologous tissue reconstruction, including techniques like the DIEP and latissimus dorsi flaps, provides natural contours and greater durability, particularly beneficial for patients undergoing radiation therapy. Advancements such as nipple-sparing mastectomy, acellular dermal matrices, and minimally invasive approaches have improved surgical outcomes and patient satisfaction. However, complications—ranging from implant-related issues like capsular contracture to donor-site morbidity—highlight the need for comprehensive preoperative planning and a multidisciplinary approach. Breast reconstruction remains a highly individualized process, emphasizing patient-centered care to optimize oncological safety, aesthetic outcomes, and quality of life.
Evaluation of Major and Trace Elements Geochemistry of Basement Complex Rocks in South -Eastern Part of Ado-Ekiti, Southwestern Nigeria
Authors:   Department of Geology, Ekiti State University, P. M. B. 5363, Ado-Ekiti, Nigeria, OA OlaOlorun , AO Talabi ,   Department of Geology, Ekiti State University, P. M. B. 5363, Ado-Ekiti, Nigeria, OO Akinola ,   Department of Geology, Ekiti State University, P. M. B. 5363, Ado-Ekiti, Nigeria
Published: December 2024

Ten fresh rock samples (3 migmatite gneisses, 3 banded gneisses and 4 granites gneisses) were geochemically analyzed for major oxides and trace elements
at Activation Laboratories Limited Ancaster, Ontario, Canada employing Inductively Coupled Plasma Atomic Emission Spectrometry (ICP-AES) technique
with a view to unravel their petrogenesis. The geochemical composition of the country rocks revealed that they are felsic rocks with average SiO2
content of
67.23%. Other oxides with average chemical compositions include Al2
O3
(14.934), FeO (4.223), MnO (0.0646), MgO (0.986), CaO (4.668), Na2
O (3.382), K2
O
(3.179), TiO2
(0.4401) and P2
O5
(0.397). Compositional features revealed a descending trend in the oxides of the basement rocks as shown; SiO2 > Al2
O3
>
CaO > Fe2
O3
> Na2
O >K2
O > MgO >MnO> TiO2
> P2
O5
. The compositional trend of the rocks suggests geologic setting of continental crust origin possibly
formed during orogenic activity. Discriminant plots revealed strong negative correlation of all the oxides with SiO2 except Na2O that has positive correlation
indicating pyroxene – hornblende and plagioclase fractionations respectively. Evaluation of the alumina variation of the rocks indicates met aluminous rocks
produced from the partial melting of meta-igneous source at low pressure. The rocks are not corundum normative as aluminum saturated index (ASI)<1,
typical of type I magmatic rocks. There are great variations among the trace elements compare to the average granite and crust values. The concentrations
of Zr and Ba are exceptionally high indicating felsic source of derivation. Also, the low average ratio of Rb/Sr (0.284) for the rocks in the study area signifies
possible depletion of Rb and/or enrichment of Sr in the gneisses. The rocks display a great range of rare earth element (REE) concentrations with Ce and
Nd enrichment. The migmatite gneiss is more enrich in the REE compare to the banded gneiss and granite gneiss. The chondrite normalized diagram
displayed a high degree of fractionation with steep pattern which was confirmed by the high values of normalized ratio of La to Yb, Ce to Yb and La to Sm.
The negative Eu anomalies in the gneissic rocks show that high amount of plagioclase was removed from the magma during fractional crystallization while
similarities in the rare earth elements (REE) pattern suggest they have similar origin. The rocks in the area are felsic and met aluminous with igneous origin.
Ensinar a argumentar na sociedade contemporânea: possibilidades e desafios teórico-práticos
Authors: Azevedo Isabel Cristina Michelan , Santos Alexandre Roberto Prudente Silva
Published: December 2024

Como o ensino e a aprendizagem de argumentação pode oferecer contribuições para a formação de sujeitos críticos na tomada da palavra em esfera pública e promove ações democráticas, este artigo parte de uma revisão de literatura para identificar as perspectivas que podem ser privilegiadas por ações escolares que objetivem promover práticas argumentativas integradoras em aulas de língua portuguesa. Os resultados obtidos indicam que antes da organização dos Parâmetros Curriculares Nacionais e da Base Nacional Comum Curricular, no Brasil, a perspectiva lógica era mais recorrente. Contudo, com a divulgação desses documentos orientadores, observou-se que as perspectivas retórica, sociointeracional e semiolinguística passam a se destacar significativamente, o que subsidia a proposta didático-pedagógica descrita ilustrativamente. A investigação concluída indica que a ênfase na multidimensionalidade argumentativa colabora com uma formação discente plural e favorável à participação social.
An examination of autopsies in a 400 bedded government hospital in Jhelum. An insight into the sudden cause of death and costs associated with autopsy in young government personnel
Authors: Naeem Uzma , Qamar Uddin Khan  , Iftikhar Ahmed Satti  , Afshan Bibi
Published: December 2024

Objective: To explore the different causes of sudden death among serving government employees.
Method: The audit study was conducted at the Pathology Department of a tertiary care hospital Combined Military Hospital (CMH) Jhelum, Pakistan, and comprised data of all autopsies between January 2017 and June 2021. Sampling technique was non probability purposive sampling technique which requires no statistical method calculation. Data was recorded related to weight of specimens, lists of tissue specimens for histopathological, chemical, and forensic examination, and the tests performed on samples of blood, urine, and other body fluids. Ethical review approval was taken from ethical review committee of the hospital dated October 2017. Data was analysed using Microsoft excel.
Results: All the 34 autopsies of male subjects were performed to explore the cause of sudden death. Coronary atherosclerosis was the most common cause of death 14(41.2%), followed by drowning 4(11.7%). Drug abuse, blood alcohol, narcotics, carbon monoxide and toxic elements were found in 5(14.7%) cases.
Conclusion: Myocardial infarction was found to be the most common cause of death among serving government employees.
Key Words: Autopsy, Coronary atherosclerosis.
Prognostic significance of D-dimer, neuron-specific enolase, and lactate dehydrogenase changes in patients with severe traumatic brain injury: a logistic regression analysis
Authors: Xie Jing , Zhang Lu , Gan Ning
Published: December 2024

The retrospective study was conducted at Baoding No.1 Central Hospital, China, and comprised data from July 2021 to January 2023, and aimed at exploring the relationship of neuron-specific enolase, D-dimer and lactate dehydrogenase with prognosis in patients with serous traumatic brain injury. Data of 100 patients was categorised into favourable prognosis group A having 50(50%) patients and unfavourable prognosis group B having 50(50%) patients, and was compared with as many healthy controls in group C. Increase in neuron-specific enolase, D-dimer and lactate dehydrogenase concentrations was significantly elevated in groups A and B compared to group C (p<0.05), and in group B compared to group A (p<0.05).
Key Words: Severe traumatic brain injury, Neuron-specific enolase, D-dimer, Lactate dehydrogenase, Risk factors.
Antimicrobial resistance patterns and bacterial profiling among dental caries patients
Authors: Jaffar Sumyya , Muhammad Kamran Taj  , Muhammad Iqbal Khan  , Masroora Ali Khan  , Arsalan Ahmad Shah  , Saima Azam
Published: December 2024

Objective: To examine the prevalence of dental caries and their antibiotic resistance patterns.
Method: The cohort study was conducted at the Centre for Advanced Studies in Vaccinology and Biotechnology, University of Balochistan, Quetta, Pakistan, from November 2022 to April 2023, and comprised bacterial dental caries samples that were processed for different biochemical parameters and antibiotic susceptibility. Data was analysed using SPSS version 2022.
Results: out of the 1,000 subjects from whom the samples were collected, 676(67.6%) were males and 324(32.4%) were females. Overall, 426(42.6%) subjects were aged 5-20 years. Of the total samples, 540(54%) were positive for pathogenic bacteria, with streptococcus mutans 256(25.6%) being the most common bacteria, followed by streptococcus mitis 194(19.4%), escherichia coli 69(6.9%) and pseudomonas aeruginosa 21(2.1%). Dental caries was more common among male patients 396 (73.3%), and the most affected age group was 5-20 years 261(48.3%). Illiterate patients 302 (56%) had more dental caries compared to the literate 238 (44.07%) patients. Antibiotic sensitivity tests revealed that most bacterial isolates were highly resistant to ampicillin, ciprofloxacin, and vancomycin.
Conclusion: Dental caries mostly affected males and those aged 5-20 years. Most bacterial isolates were resistant to ampicilin, ciprofloxacin and vancomycin.
Key Words: Anti-Bacterial, Vancomycin, Streptococcus mutans, Ciprofloxacin, Pseudomonas aeruginosa, Streptococcus mitis, Vaccinology, Dental Caries, Microbial, Ampicillin
Impact of nurse-led educational intervention on nurse’s knowledge about patient safety after cardiac catheterisation
Authors: Zahid Ali  , Amjad Ali  , Muhammad Tariq Farman  , Hira Fatima Waseem  , Tariq Aziz
Published: December 2024

Objective: To assess the impact of educational intervention on nurse's knowledge level related to patient safety after cardiac catheterisation in a tertiary care setting.
Method: The quasi-experimental study was conducted from October 2022 to May 2023 after approval from the ethics review board of Dow University of Health Sciences, Karachi, and comprised staff nurses working in cardiac catheterisation laboratory, cardiac care unit and allied departments of 4 tertiary care hospitals. After baseline assessment, those with knowledge score <70% were enlisted for educational intervention which was done in small groups and lasted about 120 minutes. Nurses’ knowledge was reassessed post-intervention. Data was analysed using SPSS 21.
Results: Findings of this study highlighted that majority of the participants 52 (66.66%) were male with the mean age of overall study contributors being 29.34±3.32 years. Mean baseline knowledge score was 1.27±0.44 which increased to 1.90±0.30 post-intervention (p<0.001). Mean knowledge score was significantly associated with demographic and professional characteristics (p<0.001).
Conclusion: The educational intervention successfully enhanced the knowledge scores of cardiac nurses regarding patient safety following cardiac catheterisation.
Key Words: Educational intervention, Knowledge, Patient safety, Cardiac catheterisation.
Palmoplantar hyperhidrosis: handicapped
Authors: Rasool Anas
Published: December 2024

Palmoplantar hyperhidrosis is a condition characterised by dysfunction of autonomic nervous system that results in overproduction of sweat from the palms and soles beyond physiological needs. It leads to social embarrassment and shattering of confidence having serious effects on quality of life1
Hyperhidrosis can be present at any age. The average age of onset for primary hyperhidrosis ranges from 14 to 25 years of age. The prevalence of Hyperhidrosis is higher among individuals 18 to 39 years of age than among adults > 65 years of age and children < 18 years of age2
Due to its embarrassing presentation and the general lack of knowledge about its medical nature, it is challenging to estimate the prevalence of Hyperhidrosis. In a developing country like Pakistan, people who don't have this condition are not aware of the stress level of the patients suffering from hyperhidrosis. The quality of their professional work, social activities, taking part in games, personal relationships are highly compromised due to constant wetness of hands and feet which in some patients leads to anxiety, depression and social isolation3.
The need of the hour is to find a treatment with a good success ratio. However, there are certain treatment options that are available but their results are not promising like antiperspirants consisting of aluminium chloride. If topical treatment fails, the patient can go for OnabotulinumtoxinA injection, units prescribed by the healthcare provider on sweaty areas (4). Another option is iontophoresis in which a mild bearable electric current is passed through your skin but its mechanism of action is not clearly understood5. some anticholinergic drugs like glycopyrrolate and oxybutynin can also be an option considering in mind that they will have a short list of side effects6. If nothing works, the last resort is sympathetic denervation7
The pressing priority is to find a permanent cure and create an awareness about this condition so that the affected people can come out of troubled waters and can live an anxiety free quality life.
Continued...
Hot Quadrate Sign Under Focus of F18-FDG PET-CT: An Incidental Finding
Authors: Ayesha Zubair  , Aamna Hassan
Published: December 2024

“Hot quadrate lobe sign” refers to visualization of caudate lobe of liver due to excess accumulation of radiotracersecondary to superior vena cava obstruction. Collateral channels are formed between thoracic and mediastinalvessels; internal mammary through the paraumbilical vessels which drain blood to the left portal vein and into thecaudate lobe of liver. It was first described on Tc99-m sulfur colloid scan. We present a case with superior vena cavaobstruction presenting as hot quadrate lobe sign on F18-FDG PET-CT.Keywords: F18-FDG PET-CT, caudate lobe, superior vena obstruction, collateral vessels.
O uso de dioramas no ensino de ecossistemas amazônicos
Authors: Barbosa Tayllen , Silva Machado Diego  Ramon
Published: December 2024

Os dioramas, cenários representativos de ambientes naturais , estimulam as habilidades artísticas dos estudantes, permitindo-lhes representar conceitos científicos de forma simplificada e visualmente impactante. Além disso, enriquecem o processo de ensino-aprendizagem em museus e escolas, promovendo um aprendizado dialógico e colaborativo. O uso de dioramas como estratégia didática no ensino de ciências desempenha um papel importante na compreensão da biodiversidade de diferentes ecossistemas, incluindo os amazônicos. Para identificar essas relações em contextos regionais, esta pesquisa avaliou o uso de dioramas no ensino de ecossistemas marajoaras por meio de uma Sequência de Ensino Investigativa (SEI) em um contexto escolar. Trata-se de uma pesquisa qualitativa, do tipo estudo de caso, realizada em uma escola pública de Salvaterra – PA, com 28 alunos de uma turma do 7º ano do ensino fundamental. Partindo de uma trilha na RESEC Mata do Bacurizal e no Lago Caraparú, os alunos criaram e expuseram seus próprios dioramas, após abordagens em sala de aula. A análise dos dados qualitativos se deu a partir dos dioramas construídos, da exposição para a turma e dos textos escritos pelos alunos sobre os ecossistemas marajoaras representados. Os resultados indicam que a estratégia contemplou três eixos da alfabetização científica: 1) compreensão básica de termos e conceitos científicos; 2) compreensão da natureza das ciências e de seus aspectos éticos e políticos; e 3) entendimento das relações entre ciência, tecnologia, sociedade e meio ambiente. Conclui-se que os dioramas são uma ferramenta poderosa para promover a alfabetização científica e a sensibilidade ambiental de forma crítica e investigativa.
Perlindungan Konsumen Pembelian Rumah Indent Siap Huni Terhadap Perilaku Ingkar Janji Developer Dalam Putusan Nomor 64/Pid.Sus/2023/PN Smg
Authors: Nabila Khairunnisa Azizia
Published: December 2024

Home is one of the needs that humans must have. This increasing need has led to developments in the housing sector. Developers or developers with all marketing strategies to attract potential consumers, Decision Number 64/Pid.Sus/2023/PN. SMG as a basis for researching consumer rights that have been violated and efforts to restore consumer rights. The writing method in this research uses a normative juridical method using secondary data, namely primary, secondary and tertiary legal materials carried out by literature study. The legal relationship between the two parties is a sale and purchase agreement. The agreement between consumers and business actors complies with Article 1320 of the Civil Code, and rights and obligations arise for the parties. Business actors promised to complete the development but were not fulfilled. Business actors violate the obligation to have good faith in carrying out their business, and offer goods that do not comply with the agreement. By not fulfilling these obligations, consumers' rights are violated because business actors do not provide correct, clear and honest information regarding the condition of the goods. Consumers can file claims for breach of contract against business actors. Business actors guarantee SHM to other parties without permission, causing losses to consumers, so compensation can be requested, according to the elements of an Unlawful Act, as well as imposing mortgage rights on the parties to declare the mortgage rights null and void. In this way, preventive and repressive protection can be created to provide protection for the parties.
Analysis of the provision of medical personnel in medical organizations providing primary health care in rural areas
Authors: Khodakova Olga V. , Senotrusova Yulia E.
Published: December 2024

Introduction. The health status in the rural population plays a critical role in the development of rural areas, therefore the priority tasks for the development of healthcare are to ensure optimal accessibility of primary health care for the rural population as well as eliminating personnel shortages in medical institutions.
Рurpose. To study the main trends in the provision of primary health care by medical personnel in rural areas for the period of 2018–2022.
Materials and methods. We used sanitary-statistical, analytical, and comparative analysis methods. The calculation of indices was based on data from the federal statistical observation form No. 30-village “Information about a medical instituion” for the period 2018–2022, information on the size of the rural population according to Rosstat of Russia.
Results. The level of provision of the rural population with doctors providing primary health care in outpatient settings tends to decrease throughout the entire observation period. There is a natural trend towards a decrease in the staffing of full-time positions of doctors providing medical care in outpatient settings with individuals in rural areas and, accordingly, an increase in the part-time ratio. The supply of doctors to the rural population to provide primary health care in federal districts has significant differences. The highest rate of decline was noted in the level of provision of the rural population with general practitioners — the figure decreased by 22.2% in 2022 compared to the level of 2018.
Research limitations. The research materials are limited to the results of the analysis of data from the federal industrial statistical observation form No. 30-village for the Russian Federation and for individual federal districts.
Conclusions. The main trends in providing the rural population of the Russian Federation with doctors providing primary health care on an outpatient basis have been identified. The task of attracting and retaining medical personnel to work in rural areas and developing mobile forms of work for medical organizations continues to remain relevant.
Centers of Social Disadvantage as a Cause of Victimhood of the External Labour Migrants
Authors: Korsakov Konstantin V. , Tsvetkova Anna D.
Published: December 2024

In all countries of the world, external labor migrants belong to a social group with increased victimization, however, the domestic science of victimology has not yet developed a holistic and universal set of measures aimed at victimological prevention against them. The initial stage in the formation of such a system of measures should be the identification of the causes and conditions that generate and contribute to the formation of victimization of migrants and its increase, which was the purpose of the study. It has been established that in determining the victimization of external labor migrants, the most important role is played by foci of social disadvantage, which are a source of increased victimization of external labor migrants and act as a specific factor of crime against the latter . These include the low standard of living and education in the countries of origin, the lack of accessible and simple, transparent mechanisms for legal residence and employment in the host State for external migrants, and the absence in the Russian Federation of a unified victimological prevention system for external migrant workers. The second group of foci includes factors related to social and household problems in national immigrant communities, temporary detention centers for foreign citizens and stateless persons, labor collectives and places of residence of immigrants in the host state . For each isolated focus, measures are proposed to influence it in order to reduce its negative impact on victimization. They can be used as a basis for further building a universal and unified system of measures to reduce the victimization of external labor migrants in Russia. The authors include among the main and most promising measures: the creation of free educational and educational courses; the development of special memos; the actual formation of a unified system of victimological prevention in Russia; the organization of special pre-placement points with the provision of legal, psychological and social assistance; normative consolidation of standards of living and work of external migrants; increasing the level of preventive work of the authorities in their activities aimed at protecting the rights and interests of external migrant workers.
Domestic Violence Victimization: Problems of Prevention
Authors: Dumanskaya Elena I.
Published: December 2024

The article analyses domestic violence victimization and factors determining domestic violence such as unconscious patterns. It argues that the victim’s pattern of behavior cannot be corrected without working with the victim’s unconsciousness. Measures of the victim’s scenario prevention are not fully effective without such a very significant factor of the victim’s behavior as unconscious attitudes and patterns. Psychologists and therapists can assist victims in changing their behaviors and patterns. Using domestic violence prevention techniques and resources, the victim can stay safe in their relationship . It is necessary to create incentives for resolving intra-family problems, as well as to professionally respond to “the victim’s pattern”, to develop family rehabilitation programs for both the aggressor and the victim. It will contribute to better prevention of domestic violence.
Protection of Minors in Online and Offline Space: the Dilemma of Cyberbullying
Authors: Shaikova Marina V.
Published: December 2024

Modern society has been mastering communication in the Internet society for more than 20 years. The social, economic, and psychological problems of the real world gradually began to be reflected in the digital space. Simultaneously with the development of the information environment, such an offense as cyberbullying began to develop, the main percentage of victims of which are children and adolescents . Aggressors using the worldwide Internet, hidden data, fake accounts can harm the chosen victim by spreading false information discrediting her honor and dignity, as well as by exerting psychological pressure and violence. The article examines the concept of cyberbullying, its elements, types, and assesses the psychological state of the victim and the cyberbuller himself. The Russian legislation is analyzed, in which, although there is no such fixed concept as cyberbullying, there are related elements of crimes and offenses . The need for interdisciplinary research (by lawyers, psychologists, educators, social educators, etc.) of bullying and cyberbullying has been identified. An algorithm for the prevention and prevention of virtual violence against minors is proposed, with the help of which it is possible to minimize the risks of victimization of adolescents.
Typological Model of the Digital Environment of Interaction Between Individuals and Investigative Bodies in Criminal Proceedings in the Russian Federation
Authors: Zadorozhnaya Vera A.
Published: December 2024

The subject of the study is the digital environment of interaction between individuals and investigative bodies in criminal proceedings in the Russian Federation. The purpose of the study is to develop a typology of development of the digital environment of interaction between citizens and investigative bodies in criminal proceedings, reflecting its development as a systemic object. The hypothesis of the study assumes the possibility of presenting the subject of the study in the form of a systemic object, organized according to the principle “from simple to complex”, possessing a number of qualities (criteria) that reflect its systemic nature. We applied a categorical method of a number of information criteria, reproducing the logic of progressive development of the digital environment of interaction between citizens and investigation bodies as its organizational complexity increases. As a result of the research: 1) information criteria reflecting the qualities of the subject of research as a systemic object (informing, information reception, counselling, communication, information evaluation) are revealed; 2) the sequence of information criteria reflecting the increasing complexity of the digital environment of interaction between citizens and investigation bodies in criminal proceedings in Russia in the process of its evolutionary development is substantiated; 3) the typology of digital environment reflecting its species diversity and evolutionary sequence is developed. The highlighted qualities of the digital environment allow: 1) monitor the current level and prospective directions of its development; 2) assess the timeliness of the introduction of certain forms of interaction between citizens and investigative bodies from the perspective of compliance with the current stage of development of the digital environment; 3) forecast possible trajectories of its evolution in both progressive and regressive directions. The results obtained can be used to develop concepts of digitalization of criminal proceedings in Russia, to substantiate possible trajectories of evolutionary development of the digital environment of interaction between citizens and bodies conducting criminal proceedings, to assess the current state of digitalization of criminal proceedings, to evaluate the effectiveness of planned transformations, to assess the implementation of the rights of citizens participating in criminal proceedings in the digital environment.
CARL CZERNY OPUS 599/30 ve 36 NUMARALI ETÜTLERİN PİYANO İCRASINA YÖNELİK KARŞILAŞTIRMALI ANALİZİ
Authors: Tunç Turgay
Published: December 2024

Bu çalışma, Carl Czerny'nin Op. 599 etüt kitabındaki 30 ve 36 numaralı etütlerin teknik ve biçimsel analizleri üzerine odaklanmaktadır. Araştırma, piyano öğrencilerinin bu etütleri daha etkin bir biçimde çalışabilmesi için detaylı çalışma yöntemleri sunmayı amaçlamaktadır. Nitel bir araştırma olan bu çalışmada doküman analizi yöntemi kullanılmış olup, 30 ve 36 numaralı etütler bu yöntemle analiz edilmiştir. Etütlerin yapısal özellikleri, kullanılan motif ve cümleler hakkında elde edilen bilgiler ışığında, geliştirilen çalışma yöntemleri sayesinde piyano öğrencilerinin bu etütleri rahatlıkla icra edebilecekleri düşünülmektedir. Çalışma sonucunda, Czerny Op. 599 etütlerinin diğer numaralarının da benzer bir şekilde analiz edilmesinin faydalı olacağı, piyano öğrencilerinin bu çalışmada sunulan yöntemleri kullanırken, kendi yaratıcılıkları yoluyla yeni çalışma yöntemlerini ortaya koymaları öngörülmektedir.
Managing public opinion in line with improving the effectiveness of law enforcement agencies
Authors:   Ufa branch of the Volga University of Water Transport, Antoshkin Victor N.
Published: December 2024

The article analyzes the problem of public opinion management. Public opinion is an important
indicator of the effectiveness of the Russian police. The author suggests using progressive models of social
communication. This will improve the quality of law enforcement agencies' work.
Azerbaijan's position in international organizations on gender equality issues
Authors:   Academy of Public Administration under the President of the Republic of Azerbaijan, Bagirli Aytach Z.-gizi
Published: December 2024

Gender equality issues significantly impact Azerbaijan's participation in international organizations. Despite progress in addressing gender disparities, challenges remain due to cultural, institutional, and policyrelated factors. Azerbaijan's underrepresentation of women in high-level political and diplomatic positions limits their influence in international forums and the diversity of perspectives in foreign policy formulation. Gender biases and stereotyping further marginalize women's contributions, affecting Azerbaijan's effectiveness and credibility in international organizations. Additionally, the lack of gender mainstreaming in policy formulation and implementation, coupled with economic inequalities, exacerbates these challenges. Addressing these
issues requires systemic changes and a comprehensive approach to integrate gender perspectives into all aspects of foreign policy, ensuring more inclusive and effective global strategies. Continued collaboration with international organizations like UNDP and UNESCO is crucial for sustaining progress and promoting gender equality in Azerbaijan's international engagements.
The Russian language in the technology of «soft power» in the countries of Transcaucasia
Authors:   Peter the Great St. Petersburg Polytechnic University, Khusainova Sofia S.
Published: December 2024

The article examines the functioning of the Russian language in two Transcaucasian republics of
the CIS — Azerbaijan and Armenia. Despite the high proportion of the titular ethnic group in both republics, they still remain multinational. Therefore, the Russian language in them has continued to play the role of the language of interethnic communication since Soviet times. The post-Soviet period made certain adjustments to the language policy in these republics, especially in terms of the legal framework, which was clearly reflected in the constitution of both countries and in the adopted new laws on language. Russian Russian remains in demand and enjoys the support of the population of the republics, despite the gradual removal of even mention of the Russian language in the basic laws.