bluuebunny/crossref_metadata_2025 huggingface dataset:
Fluoxetine decreases phagocytic function via REV-ERBα in microglia
Authors: Jang Da-Yoon , Yang Bohyun , You Min-Jung , Rim Chan , Kim Hui-Ju , Sung Soyoung , Kwon Min-Soo
Published: July 2022

Although fluoxetine (FLX) is a commonly used drug in psychiatric disorders, such as major depressive disorder (MDD), anxiety disorder, panic disorder, and obsessive-compulsive disorder (OCD), the mechanism by which FLX exerts its therapeutic effect is not completely understood. In this study, we aimed to determine the possible mechanism by which FLX focuses on microglial phagocytosis. FLX reduced phagocytic function in BV2 cells and increased REV-ERBα among circadian genes without affecting other microglia-related genes, such as inflammation and phagocytosis. Although FLX did not change BMAL1 protein levels, it restricted the nucleocytoplasmic transport (NCT) of BMAL1, leading to its cytosolic accumulation. REV-ERBα antagonist SR8278 rescued the decreased phagocytic and restricted NCT of BMAL1. We also found that REV-ERBα mediates the effect of FLX via the inhibition of phospho-ERK (pERK). The ERK inhibitor FR180204 was sufficient to reduce phagocytic function in BV2 cells and restrict the NCT of BMAL1. These results were recapitulated in the primary microglia. In conclusion, we propose that FLX decreases phagocytic function and restricts BMAL1 NCT via REV-ERB. In addition, ERK inhibition mimics the effects of FLX on microglia.
Comparison of Fasting and Random Lipid Profile among Subjects with Type-2 Diabetes Mellitus Patients: An Outpatient-Based Cross-Sectional Study in Bangladesh
Authors: Kamrul-Hasan A. B. M. , Talukder Samir Kumar , Kabir Md. Ahamedul , Mustari Marufa , Nabi Md. Masud Un , Gaffar Abu Jar , Hossain Md Firoj , Alam Muhammad Shah , Islam Md. Rashedul , Hannan Mohammad Abdul , Zarin Nusrat , Paul Ajit Kumar , Akter Farhana , Ahammed Afsar , Kabir Md Lutful , Rahman Mohammad Motiur , Asaduzzaman Md , Saifuddin Mohammad , Chanda Palash Kumar , Rafi Md. Abdur , Hasan Mohammad Jahid , Selim Shahjada
Published: July 2022

Background: Despite the wide acceptability of fasting lipid profile in practice, emerging evidence suggests that random lipid profile might be a convenient alternative for lipid measurement. The objective of the present study was to compare the fasting and random lipid profile among subjects with T2DM.Methods: The present cross-sectional study included 1543 subjects with T2DM visiting several endocrinology outpatient clinics throughout Bangladesh from January to December 2021. The fasting lipid profile was measured in the morning following 8-10 hours of overnight fasting, and the random lipid profile was measured at any time of the day irrespective of the last meal. The values of fasting and random lipids were compared using the Wilcoxon signed-rank test and Spearman rank correlation coefficients.Results: In this study, a good level of correlation was observed between fasting and random lipid levels [r = 0.793, p <0.001 for triglyceride (TG), r = 0.873, p <0.001 for low-density lipoprotein cholesterol (LDL-C), r = 0.609, p <0.001 for high-density lipoprotein cholesterol (HDL-C), and r = 0.780, p <0.001 for total cholesterol (TC)]. In addition, TG and TC levels increased by 14% and 0.51%, respectively, in the random state compared to the fasting state (p- <0.05), while LDL-C levels decreased by 0.71% (p value 0.42). No change was noticed in the HDL-C level. The difference between fasting and random lipid profile was similar according to age, sex, BMI, glucose-lowering drug(s), and lipid lowering therapy.Conclusions: Random lipid profile correlates significantly with fasting lipid profile with little difference. Hence, it might be a reliable alternative for fasting lipid profile in T2DM patients.
Utilisation of modern contraceptives by sexually active adolescent girls in Rwanda: a nationwide cross-sectional study
Authors: Kawuki Joseph , Gatasi Ghislaine , Sserwanja Quraish , Mukunya David , Musaba Milton W.
Published: July 2022

Background
Modern contraceptive use has been shown to influence population growth, protect women’s health and rights, as well as prevent sexually transmitted infections (STIs) for barrier contraceptive methods such as condoms. The present study aimed at assessing the level of utilization and factors associated with modern contraceptive use among sexually active adolescent girls in Rwanda.
Methods
We used secondary data from the Rwanda Demographic and Health Survey (RDHS) 2020 data of 539 sexually active adolescent girls (aged 15 to 19 years). Multistage stratified sampling was used to select study participants. We conducted multivariable logistic regression to assess the association between various socio-demographics and modern contraceptive use using SPSS version 25. Modern contraception included the use of products or medical procedures that interfere with reproduction from acts of sexual intercourse.
Results
Of the 539 sexually active girls, only 94 (17.4%, 95%CI: 13.8–20.1) were using modern contraceptives. Implants (12.1%) and male condoms (2.1%) were the most used options. Modern contraceptive use was positively associated with older age (AOR = 10.28, 95%CI: 1.34–78.70), higher educational level (AOR = 6.98, 95%CI: 1.08–45.07), history of having a sexually transmitted infection (AOR = 8.27, 95%CI: 2.54–26.99), working status (AOR = 1.72, 95% CI: 1.03–2.88) and being from a female-headed household (AOR = 1.96, 95% CI: 1.12–3.43). However, marital status (AOR = 0.18, 95%CI: 0.10–0.35) and region (AOR = 0.28, 95% CI: 0.10–0.80) had negative associations.
Conclusions
To promote utilisation of modern contraceptives, family planning campaigns need to place more emphasis on the younger, unmarried adolescents, as well as those with lower educational levels. Consideration of household and regional dynamics is also highlighted.
Sexual and Reproductive Health and Rights in Emergency Communities. A survey on the Kyaka II Refugee Settlement, South Western Uganda
Authors: Magezi Alex , Mairah Faith
Published: July 2022

IntroductionEven thought, a lot of funding has been injected in Sexual and Reproductive Health and Rights (SRHR), sadly, the area is still poorly addressed and unfulfilled. For the case of Kyaka II Refugee, little or no research is available on SRHR.PurposeThis survey sought to find out the prevailing status of SRHR services, in the Kyaka II refugee settlement.MethodsUsing stratified sampling, primary data was collected from 117, females aged 12 to 60 years. 13 respondents were randomly picked from each of the 9 zones of the settlement.FindingsThe study found out low (20%) prevalence of; Sexual Health, Sexual Rights, Reproductive Health and Reproductive Rights, in the refugee settlement.Value/ RecommendationThis study is valuable to funders, policymakers and organizations responding to Sexual and Reproductive Health and Rights in refugee communities. Therefore, more funding allocation, in the areas of SRHR in the settlement, is recommended by the study.
The Impact of an Enhanced Recovery After Surgery Pathway for Video-Assisted and Robotic-Assisted Lobectomy on Surgical Outcomes and Costs: A Retrospective Single-Center Cohort Study
Authors: Han Shiwei , Du Simo , Jander Christina , Kuppusamy Madhan , Sternbach Joel , Low Donald E , Hubka Michal
Published: July 2022

Objective
To determine the impact of enhanced recovery after surgery (ERAS) pathway implementation on outcomes and cost of robotic- and video-assisted thoracoscopic (RATS and VATS) lobectomy.
Methods
Retrospective review of 116 consecutive VATS and RATS lobectomies in the pre-ERAS (Oct 2018-Sep 2019) and ERAS (Oct 2019-Sep 2020) period. Multivariate analysis was used to determine the impact of ERAS and operative approach alone, and in combination, on length of hospital stay (LOS) and overall cost.
Results
Operative approach was 49.1% VATS, 50.9% RATS, with 44.8% pre-ERAS, and 55.2% ERAS (median age 68, 65.5% female). ERAS patients had shorter LOS (2.22 vs 3.45 days) and decreased total-cost ($15,022 vs $20,155) compared with non-ERAS patients, while RATS was associated with decreased LOS (2.16 vs 4.19 days) and decreased total-cost ($14,729 vs $20,484) compared with VATS. The combination of ERAS + RATS showed the shortest LOS and the lowest total-cost (1.35 days and $13,588, p < 0.001 vs other combinations). On multivariate analysis, ERAS significantly decreased LOS (P = 0.001) and total-cost (P = 0.003) compared with pre-ERAS patients; RATS significantly decreased LOS (P < 0.001) and total-cost (P = 0.004) compared with VATS approach.
Conclusion
ERAS implementation and robotic approach were independently associated with LOS reduction and cost savings in patients undergoing minimally invasive lobectomy. A combination of ERAS and RATS approach synergistically decrease LOS and overall cost.
A volumetric dilemma: Large basal ganglia in medication-naive first episode psychosis
Authors: Yesilkaya Umit Haluk , Sen Melten , Yuzbasıoglu Neslihan , Pence Kadriye Betul , Karamustafalioglu Nesrin
Published: July 2022

The neurotransmitter hypothesis is one of the most important hypothesis for the etiology of schizophrenia. Glutamate and dopamine dysfunction in the subcortical structures has been implicated in most of the symptoms of schizophrenia, especially positive symptoms. Magnetic resonance imaging (MRI) studies have demonstrated differences in the subcortical structure of patients with schizophrenia as compared to controls. We aimed to investigate whether the basal ganglia volume was different in medication-naive first period of schizophrenia. Seventy-one drug-naïve patients with first-episode psychosis(FEP) who applied to outpatient clinics and were diagnosed according to DSM-5 as well as 47 healthy controls(HC) were included in the study (n=118, 64 male, 54 female). T1-weighted images were acquired on a 1.5 T scanner (Magnetom SP, Siemens), and basal ganglia volume was measured using the VolBrain software. Symptoms were assessed by using Positive and Negative Syndrome Scale (PANSS) by an experienced psychiatrist. The volumes of right(R) and left(L) striatum, R- and L-caudate, and R- and L- Substantia nigra (SN) were found to be higher in FEP patients compared to HC. While the volume of L-putamen was higher, L- Globus pallidus (GP) and L-nucleus accumbens (NAcc) were smaller in FEP compared to HC. No significant correlation was found between volume measurements and PANSS scores. R-CAU, L-CAU, R-Striatum, L-Striatum, L-Putamen, L-NAcc, R-GP and L-SN were found to significantly predict psychosis in an univariate Logistic Regression Model. Basal ganglia are affected from the first stage of the disease in schizophrenia and may play a role in the pathogenesis of the disease.
Validation of concurrent models of public values towards invasive alien animal species based on Kellert’s attitudinal dimensions
Authors: Šorgo Andrej , Bezjak Urška , Špur Natalija
Published: July 2022

One of the major causes of biodiversity loss is invasive alien species (IAS). Successful IAS management requires collaboration between multiple public groups. For effective collaboration, to avoid misunderstanding and conflict, knowledge about and understanding of people's perceptions and attitudes toward IAS and their management are crucial. Therefore, the aim of our study was to explore the dimensions of attitudes toward IAS. We constructed a 40-item instrument, with four items indicating each dimension. With the application of Principal Component Analysis, nine components emerged, explaining 58% of the variance, but not following the theoretically predicted dimensions. The models revealed that the utilitarian attitude is the most representative. In all probability, the most important finding is that IAS should receive treatment equal to that of autochthonous animals (killing is killing). When preparing a campaign or a rationale for action, the most important dimensions are those designated as Control, Utilitarian, and Disinterest.
Investigation of the usability of Wide Wheel Abrasion test on rock core samples and proposal of a core abrasion index
Authors: Kolgitti Tufan , Çelik Sefer Beran
Published: July 2022

In this study, the usability of the Wide Wheel Abrasion Test (WA) on rock cores by using a newly designed core holder apparatus is investigated. The WA test which has been proposed to determine the abrasion resistance of rocks used as natural building stones is carried out on only prismatic samples. In the design of rock engineering structures such as tunnels, dams and investigations for various purposes, samples are supplied as cylindrical cores from exploration drillings. The applicability of this test on cylindrical samples is the scope of this study. Physical and mechanical properties of nine types of rock materials are determined on these core samples in accordance with the relevant standards and suggested methods. In the context of this study, core samples with average diameters of 26.76, 39.72, 47.80, 58.16 and 67.51 mm were prepared. After that, the Wide Wheel Abrasion tests on core samples (IA) were carried out. It is obvious that the abrasion values obtained on samples with different diameters will differ. To overcome this uncertainty applying core abrasion test on samples with 50 mm diameter is suggested and it is proposed as core abrasion index (IA−50). If needed, applicability of IA−50 test on half-cut cores (IA−HC) was also investigated, and significant linear correlation was obtained. IA−50 values were correlated with rock material parameters and significant relationships were proposed. It is believed that practical, economical, and non-destructive determination of IA−50 values will be effective to make the approach more widespread, and it will be useful in various rock engineering applications as a new parameter.
Human Adipose-Derived Stem Cells Can Optimize the Filling Material in Rats
Authors: Qu Siwei , Ma Ning , Wang Weixin , Chen Sen , Wu Qi , Li Yangqun , Yang Zhe
Published: July 2022

Introduction: Human adipose-derived stem cells have been identified as a promising candidate for cell-assisted therapy to improve graft survival. Human adipose-derived stem cells were added into filling materials. Methods: The filling materials were prepared and divided into 6 groups: Fat particles with phosphate buffer saline or human adipose-derived stem cells; Acellular dermal matrix particles with phosphate buffer saline or human adipose-derived stem cells; Mixture of fat particles and acellular dermal matrix particles with phosphate buffer saline or human adipose-derived stem cells. The survival rate, vascular density and histological at 2, 6 and 12 weeks were investigated. Results: Human adipose-derived stem cells significantly improved survival rate in each group at 6 and 12 weeks, and it significantly increased the vascular density in the fat particles and porcine acellular dermal matrix combined group and porcine acellular dermal matrix group at three time points, but human adipose-derived stem cells did not have a significant effect in the fat particles group. Conclusion: Human adipose-derived stem cells as assisted cells added into filling material can improve survival rate and vascular density in rats.
Sequentially Clustered Social Opinion for Improved Customer Management in Churn prediction
Authors: Ibitoye Ayodeji O.J , ONIFADE Olufade F.W.
Published: July 2022

As business competition continues to increase in different sectors of the economy, chum prediction models as a social behaviour have continued to impact the classification of customers for enhanced decision support and recommendations through text analytics. While it is generally believed that user’s opinion can be gradually influenced by friends on the social media, the prospect of a churning customer increases proportionately when the friend churns. However, oftentimes, during media exchange on the social network, customers are treated distinctly for positive, negative and neutral opinion classifications. By this, the network structure, sequential conversion and its influence on the user community content is neglected for churn prediction. Thus, by developing an opinion-based churn prediction model through sequential content clustering, this research explores user’s media conversation to understand the intrinsic mechanisms of sequentially formulated opinion in a social network community. Consequently, the computational similarities and sentiment between text were extracted to build an opinion driven churn prediction community for enhanced targeted customer acquisition and retention support. The essence is to harness the power of the social networking as replica for mouth-to-mouth conversation on products brands in Natural Language Processing. The research obtained 95%, 87%, and 94% in Recall, Precision, and Accuracy respectively when compared with opinion mining from ordinary data clustering.
Small peptide LINC00511-133aa encoded by LINC00511 regulates breast cancer cell invasion and stemness through the Wnt/β-catenin pathway
Authors: Tan Zhongqiu , Zhao Lifeng , Huang Shiqing , Jiang Qiulan , Wei Yantao , Wu Junyun Long , Zhang Zhiwen , Li Yepeng
Published: July 2022

The stemness and invasion of breast cancer cells are key causative factors for tumor relapse and metastasis. The present study aimed to identify whether LINC00511-133aa, a small peptide encoded by LINC00511, could mediate the wnt/β-catenin pathway to control the invasiveness and stemness of breast cancer cells. In this study, LINC00511-133aa and control vector were transfected into breast cancer cells (MCF-7 and MDA-MB-231). Afterward,) PCR, western blot, and immunofluorescence assays were conducted to assess the expression of the small peptide LINC00511-133aa. Cell proliferative and invasive potentials were subsequently evaluated using CCK8, apoptotic, scratch, and transwell invasion assays. Finally, cancer stem cell-like characteristics were identified by the sphere-forming assay and western blot analysis of the stemness markers (Oct4, Nanog, and SOX2). The results show that the small peptide LINC00511-133aa was determined to be encoded by LINC00511. Transfection with this peptide expedited the invasion ability of breast cancer cells, strengthened their stemness, and limited apoptosis. Finally, LINC00511-133aa activated the wnt/β-catenin pathway. in sum, LINC00511 can encode the small peptide LINC00511-133aa, which can modulate the invasiveness and stemness through the regulation of the wnt/β-catenin pathway.
Longitudinal associations of sedentary behavior and physical activity with body composition in colorectal cancer survivors up to 2 years post-treatment
Authors: Kenkhuis Marlou-Floor , Klingestijn Mo , Fanshawe Anne-Marie , Breukink Stephanie , Janssen-Heijnen Maryska , Keulen Eric , Rinaldi Sabina , Vineis Paolo , Gunter Marc J. , Leitzmann Michael F. , Scalbert Augustin , Weijenberg Matty , Bours Martijn , Roekel Eline Van
Published: July 2022

Purpose: We investigated longitudinal associations of sedentary behavior, light-intensity physical activity (LPA) and moderate-to-vigorous physical activity (MVPA) with body composition in colorectal cancer (CRC) survivors, between 6 week and 24 months post-treatment. In addition, we explored whether body composition mediated associations of sedentary behavior and MVPA with fatigue. Method: A prospective cohort study was conducted in 459 stage I-III CRC patients recruited at diagnosis. Measurements were performed of accelerometer-assessed sedentary time (hours/day), self-reported LPA and MVPA (hours/week), anthropometric assessment of body mass index (BMI), waist circumference and fat percentage (measures of adiposity), and muscle circumference and handgrip strength (measures of muscle mass/function) repeated at 6 weeks, and 6, 12 and 24 months post-treatment. Longitudinal associations of sedentary time and physical activity with body composition were analyzed using confounder-adjusted linear mixed models. Mediation analyses were performed to explore the role of body mass index (BMI) and handgrip strength as mediators in associations of sedentary time and MVPA with fatigue. Results: Less sedentary time and LPA were, independent of MVPA, longitudinally associated with increased handgrip strength, but not with measures of adiposity. More MVPA was associated with increased adiposity and increased handgrip strength. Higher BMI partly mediated associations between higher sedentary time and more fatigue. Conclusion: Within the first two years after CRC treatment, changes in sedentary behavior, physical activity and body composition are interrelated and associated with fatigue. Intervention studies are warranted to investigate causality.
Debilitating Gentamicin Ototoxicity: Case Report and Recommendations Against Routine Use in Surgical Prophylaxis
Authors: Kalmanson Olivia A. , McLoughlin Kaitlin C. , Kiser Tyree H. , Gubbels Samuel P.
Published: July 2022

Purpose: Aminoglycoside antibiotics such as gentamicin are bactericidal and effective against gram negative organisms and methicillin-resistant Staphylococcus aureus. However, they have serious adverse effects such as nephrotoxicity and ototoxicity. Gentamicin ototoxicity may occur after a single dose and results in decreased vestibular function, which is frequently debilitating and often permanent. The purpose of this report is to describe a case of ototoxicity after a single dose of gentamicin for surgical prophylaxis and suggest second-line antibiotics in penicillin-allergic patients undergoing colorectal surgery.Methods: A case is described of a woman with preexisting Meniere’s Disease who received gentamicin perioperatively for a sigmoidectomy. Results: The patient developed severe ototoxicity preventing her from working or driving. Gentamicin is indicated for surgical prophylaxis when a patient has a true allergy to penicillins and cannot receive cephalosporins, though alternatives exist. True allergies include IgE-mediated illness (anaphylaxis, bronchospasm, or urticaria 30-60min after administration) or exfoliative reactions (Stevens-Johnson Syndrome or Toxic Epidermal Necrolysis). Conclusion: The authors encourage more prudent use of gentamicin, especially in patients susceptible for debilitating otologic insults, and offer recommendations for alternative agents in colorectal surgery prior to choosing gentamicin.
A consistent assessment of trees inside and outside forests improves estimates of total tree cover in Africa
Authors: Reiner Florian , Brandt Martin , Tong Xiaoye , Skole David , Kariryaa Ankit , Ciais Philippe , Davies Andrew , Hiernaux Pierre , Chave Jerome , Mugabowindekwe Maurice , Igel Christian , Oehmcke Stefan , Gieseke Fabian , Li Sizhuo , Liu Siyu , Saatchi Sassan , Boucher Peter , Singh Jenia , Taugourdeau Simon , Dendoncker Morgane , Song Xiao-Peng , Mertz Ole , Tucker Compton J. , Fensholt Rasmus
Published: July 2022

The consistent monitoring of trees both inside and outside of forests is key to mitigating climate change. Current monitoring systems either ignore trees outside forests or are too expensive to be applied consistently across countries on a repeated basis. Here we make use of the PlanetScope nanosatellite constellation, which delivers global very high-resolution daily imagery, to map both forest and non-forest tree cover for continental Africa using images from a single year. Our prototype map of 2019 demonstrates that a precise assessment of all tree-based systems is possible at continental scale, and reveals that 29% of tree cover is found outside areas previously classified as tree cover, such as in croplands and grassland. Such accurate mapping of tree cover at metric resolution down to the level of individual trees and consistent among countries has the potential to redefine land use impacts, move beyond the need for forest definitions, build the basis for natural climate solutions, and provide a new scientific basis for tree related studies.
THE INFLUENCE OF NATURAL RESOURCE AND GEOPOLITICAL FACTORS ON THE FORMATION AND DEVELOPMENT OF RAILWAY TRANSPORT IN RUSSIA
Authors:   Chita Institute of Baikal National University, Chita, Vikulova E.
Published: July 2022

The influence of natural resource and geopolitical factors is traced in the formation of the country's transport system, the location of its main highways. It is these factors that determine the structure of the transport system of the country and the regions; they determine the nature and directions of the emerging transport flows and the specifics of the socio-economic development of the subjects of the Russian Federation. In the period of the changing geopolitical picture of the world, transport is also being reoriented, which requires more flexible predictive models of its development for a more efficient, well-coordinated and uninterrupted operation. Monitoring and studying natural resource and geopolitical factors is important and significant for the economic system of the whole country and its infrastructure. The object of the study is railway transport. The subject of the study is his activity. The purpose of the study is to scientifically substantiate the need to take into account the influence of the above factors on the development of railway transport in the medium and long-term periods. The objectives of the study are: to identify the influence of the natural resource factor on the formation and development of railway transport in the historical aspect; to assess the geopolitical factors in the development of transport highways. The methodology and methods of research are based on the application of natural resource, geopolitical approaches. The study uses a retrospective analysis of the cargo turnover of railway transport for 2008-2021 on the railway network. Taking into account the revealed trends, the need to develop a model for regulating the activities of railway transport under the influence of the factors under consideration is scientifically justified
LOCAL LEVEL BUDGET FORMATION SYSTEM: THEORETICAL ASPECTS, TRENDS AND DEVELOPMENT PROSPECTS
Authors: Humenna Y. H. , Storozhenko D.V.
Published: July 2022

This article is devoted to the study of the peculiarities of the functioning the system of budgeting local levels in Ukraine. The aim of the article is to study the theoretical aspects of the local budget system, to conduct the analytical assessment of trends in the functioning of local budgets and to study the prospects for their further development. Systematization of literature sources to determine approaches to the essential component of the local budget allowed defining the local budget as detailed plan for the use of financial resources, economic relations related to improving the social life of citizens. Based on the functional approach to regionalization of taxation, the scheme of the system of local budget formation has been formalized. It allows taking into account the influence of objective and subjective factors. The article considers the key tasks and vectors of the local budget system. As part of the analysis of current trends in the development of local budgets, the diagnosis of revenues and expenditures for the period from 2015 to 2020 is hold.
The results of the analysis showed volatile dynamics in the comparability of revenues and expenditures of local budgets and provided an opportunity to obtain a comprehensive assessment of intergovernmental transfers from the budget of Ukraine for socio-economic development of regions to reduce their economic differentiation and ensure the implementation of state regional powers. The analysis of the revenue and expenditure part of the local budget of Ukraine allowed studying in more detail the peculiarities of local budget formation, identifying certain patterns and forming measures to prevent emerging problems in budget execution in the country. Taking into account the defined system of formation of local level budgets and the analysis of strengths and weaknesses of budgets functioning the basic directions of maintenance and perspective development of budgets of local levels are considered. These include: increasing tax and non-tax revenues to the budget due to the set of measures at the local and regional levels; increasing the level of efficiency of intergovernmental transfers; improving the methodological and practical aspects of encouraging economic entities to increase their own incomes.
Do E-Government Services Affect Jordanian Customer Loyalty?
Authors: Alnaser Ahmad Salih , Theep Khaled Alshake , Alhanatleh Hasan
Published: July 2022

E-governance could be understood as the performance of the governance via the electronic medium to facilitate a transparent, efficient, and speedy process for making information readily available to the public, government organs, and other social agencies to perform administration activities of the government. Likewise, e-governance has become the most adopted instrument to transform government functionaries in service delivery. Therefore, the current study was carried out to investigate the effect of e-government services dimensions (Protection Perception, Data Protection Act, Available Information, and Government Commitment) on Jordanian customer loyalty. This study adopted a quantitative research method to gather data from customers related to the e-governance service facilities in Jordan. The findings showed that Information and Communication Technology (ICT) advancement through the adoption of e-governance is not significant in Jordan. Along with adoption, the performance indices related to e-governance showed poor performance of the Jordanian government's official website. The commitment such as REACH25 of Jordan aims to digitize government services on the public platform. Absent of a dedicated data protection act and regulation makes it harder for government agencies to deal with the data breach issue. To protect customers' loyalty to the e-governance of Jordan, its government needs to address the grievances of the customers that suffer from online fraud. Accordingly, it has become imperative for the Jordanian government to adopt the best practices of e-governance from developed countries to enhance their customer's experiences. Jordanian government could adopt the data protection act in line with the European Union's general data protection regulation to protect data flow across boundaries. By adopting robust data regulation, the Jordanian government could ensure that the generated data is processed and stored in the country and other regulations regarding sharing data between countries
TRANSICIÓN AL APRENDIZAJE VIRTUAL Y SUS EFECTOS: TECNOESTRÉS EN ESTUDIANTES UNIVERSITARIOS EN EL CONTEXTO DE LA COVID-19
Authors: Cruz Covarrubias Lucila Patricia , Aguilar Pérez Pedro
Published: July 2022

El presente trabajo de investigación tiene como objetivo analizar el nivel del tecnoestrés, sus causas y efectos, en estudiantes de la Universidad de Guadalajara, bajo el contexto de la educación online, durante la pandemia de la COVID-19. La metodología empleada es de enfoque cuantitativo, tipo descriptivo, no experimental. El instrumento utilizado fue el Cuestionario de Tecnoestrés (RED-TIC) de Salanova, los «efectos» por Jena, y las «causas» por Suh y Lee: instrumentos con niveles de confiabilidad y validez aceptables, y comprobables. Con una encuesta aplicada virtualmente a través de Google Froms, a una muestra de 221 estudiantes universitarios. Los hallazgos encontrados exponen que los estudiantes manifiestan tener un nivel moderado de tecnoestrés. Las dimensiones que más influyen en este padecimiento son: sobrecarga de trabajo; ambigüedad de rol, y aspectos individuales, como el neuroticismo. Respecto de los efectos, se encontró que los universitarios no están satisfechos con la modalidad online y reconocen que su aprendizaje no ha sido del todo satisfactorio. Se concluyó que es primordial y forzoso plantear proyectos y estrategias, que reduzcan este padecimiento en los estudiantes. Se sugiere tomar acciones y asignar recursos, con la finalidad de mejorar la satisfacción, el rendimiento y la calidad de la educación.
JÓVENES EN LA INTERCULTURALIDAD: LOS CASOS DE UNIVERSIDADES INTERCULTURALES DE CHIAPAS E HIDALGO
Authors: Camacho Cruz Angélica , Galindo Jaimes Luis , Marín Levario Carmen Guadalupe
Published: July 2022

A partir del Primer Encuentro Virtual, entre las actualmente doce Universidades Interculturales presentes en el mismo número de estados de México, fue posible emitir una convocatoria dirigida a jóvenes estudiantes y egresados de ellas (agosto 5 a septiembre 10, 2021), con el objetivo de compartir experiencias sobre la educación integral y trabajo comunitario en la Universidad Intercultural de Chiapas (UNICH) y Universidad Intercultural del Estado de Hidalgo (UIEH), principalmente. La investigación cualitativa, en el área de la educación superior, posibilitó aplicar el instrumento (formulario en línea) que fue respondido de manera anónima por una muestra de alrededor de 550 jóvenes, de 19 lenguas originarias diferentes y constó de 25 reactivos (18 cerrados y 7 abiertos). El 70% de quienes respondieron tienen 18 a 21 años de edad y el 25 % son jóvenes y adultos jóvenes de 22 a 29 años. De entre los principales hallazgos y conclusiones destaca una mayor participación de mujeres: en mayor porcentaje (~45%) eligen a estas universidades por las licenciaturas que ofrecen. Tres de cada diez jóvenes, mencionó una posible deserción por problemas económicos y, finalmente, la vinculación comunitaria la consideran actividad esencial a la que debe darse mayor apoyo en todos los sentidos.
«LA HERMENÉUTICA EN LA EDUCACIÓN», EN HECHOS E INTERPRETACIONES, HACIA UNA HERMENÉUTICA ANALÓGICA
Authors: González Nares Gabriel
Published: July 2022

¿Cuál es la aportación de Mauricio Beuchot en el sentido pedagógico? Es bien conocido el valioso trabajo del filósofo y profesor mexicano Mauricio Beuchot en el ámbito de la Hermenéutica. Pero, ¿cómo aterrizar estos aportes al ámbito pedagógico? La respuesta reside en su propuesta de la Pedagogía analógica, pues ella privilegia el diálogo como herramienta para acortar distancias entre quienes creen que están en un contexto de oposición. El libro «Hechos e Interpretaciones, hacia una Hermenéutica Analógica», aborda el núcleo de esta propuesta hermenéutica y también sus principales aplicaciones filosóficas; entre ellas destaca la educación analógica.
Potencialidades de una ruta transfronteriza de senderismo en Baja California, México
Authors: Mungaray Alejandro , López Sergio Bernardino , Moctezuma Patricia , Arroyo Cossío A. Julián
Published: July 2022

Se propone la organización de una ruta abierta de senderismo en Baja California (bc) que articula las distintas ofertas particulares, algunas vinculadas a Estados Unidos, dentro de la red de caminos rurales que unen a bc desde el pie de La Rumorosa, hasta la llegada al Valle de Guadalupe. Se asume que es el contexto transfronterizo el que genera fuentes de demanda, pero también la creciente influencia de los nuevos paradigmas que promueven un desarrollo regional sustentable. La definición de la ruta se basa en un enfoque descriptivo-cualitativo con diferentes instrumentos de recolección de datos, como recorridos, mediciones y cuestionarios. Se detectaron al menos cinco espacios que están atendiendo población extranjera y fronteriza (El Topo, El Sausalito, Bethel, Escuela de Energía Solar, La Ponderosa), cuya promoción dentro de un esquema articulado de negocios sociales puede generar una dinámica de crecimiento regional.
An Experimental Study on the Healing Effect of Water to Traditional Sudanese Liquor (Aragi)-induced Stomach Peptic Ulcers
Authors: Yousif Entisar Kuku , Mustafa Howeida Abdullah , Idris Alkhair Abd Almahmoud
Published: July 2022

Background: Peptic ulcer is one of the most common gastrointestinal tract diseases which affect the stomach. This study aimed to determine the effect of aragi on the adult rats' stomach and investigate the effect of water as a therapeutic agent on aragi-induced ulcerations.Materials and methods: Thirty-five adult Wistar albino rats were used in this experimental study. Five rats were sacrificed on day 0, 5 rats were used as a control group, and 25 rats were treated with aragi. On day 15, all rats in the control group and five aragi-treated rats were sacrificed for histological examination of the stomachs. The remaining 20 rats were stopped from aragi intake and 10 of them were treated with water for 15 days. After 15 day, all rats were sacrificed for histopathological examination of their stomachs. Stomach tissues were stained using hematoxylin and eosin (H&E) and documented under a microscope.Results: Our research showed that aragi-treated rats had different severity of peptic ulcers after 15 days of continuous aragi intake, while the control group showed normal stomach histology. Nine out of 10 rats treated by water after aragi treatment also showed normal stomach histology.Conclusion: Aragi is a causative agent for peptic ulcer and water can be used as potential natural therapy for treating ulcerative stomach.Keywords: aragi, water, stomach, peptic ulcer
Development of Recombinant Immunoblot Assay Diagnostic Test Based on HIV-1 in Indonesia
Authors: Christian Jeanne Elvia , Widyaningtyas Silvia Tri , Bela Budiman
Published: July 2022

Background: High mutation rates in HIV-1 could affect the accuracy of diagnostic tests. Therefore, recombinant antigen that has an immunodominant and conserved region from HIV-1 need to be developed to detect HIV-1 infection in Indonesia.Materials and methods: The recombinant antigens comprise of Gag (p24), Pol and Env (gp41). Each antigens was expressed in the Escherichia coli expression system and purified using Ni-NTA chromatography. The reactivity of purified antigen against HIV antibodies was tested against a group of 50 HIV-positive plasma samples and 45 HIV-negative plasma samples in a recombinant immunoblot assay (RIBA) platform test. Moreover, 21 of 50 HIV-positive samples and 3 of 45 HIV-negative samples were also tested using HIV blot 2.2 to compare RIBA with a commercial western blot kit. Ten HBV-positive and 10 HCV-positive plasma samples were used to check cross-reactivity with HIV recombinant proteins in RIBA.Results: All HIV-positive samples (100%) tested with RIBA were reactive towards Gag (p24), Pol, Env (gp41). Otherwise, 3 of 21 HIV-positive samples assayed with HIV blot 2.2 were not reactive to Pol protein. All HIV-negative samples tested with RIBA and 3 HIV-negative samples tested with HIV blot 2.2 did not produce any bands of HIV antigens. Few HBV and HCV samples showed reactivity towards HIV recombinant proteins.Conclusion: Each recombinant protein, Gag (p24), Pol, Env (gp41), could be expressed and purified, as well as had reactivity to HIV-positive samples in RIBA test. Therefore, RIBA can be used as a diagnostic test to detect HIV-1 infection in Indonesia.Keywords: diagnostic, HIV-1, immunodominant, recombinant immunoblot assay (RIBA)
Das missivas aos modos
Authors: Ribeiro Guimarães Vinci Christian Fernando , Regina Ribeiro Cintya
Published: July 2022

Almeja-se compreender a intricada relação entre as noções de experimentação e prudência no interior dos tomos integrantes da coleção Capitalismo & Esquizofrenia, escrita por Gilles Deleuze e Félix Guattari, bem como os modos como cada tomo operacionalizou suas empreitadas de pensamento à baila de alguns elementos metodológicos do trabalho conjunto desses autores. Essa discussão, passível de ser conduzida tanto por meio da análise das cartas trocadas entre Deleuze e Guattari aquando da elaboração de Capitalismo & Esquizofrenia, quanto da leitura das notas compiladas por Guattari nessa mesma época, pode contribuir sobremaneira para o trabalho de pesquisadores/as interessados/as em operar metodologicamente a partir do aporte teórico-conceitual deleuziano e/ou deleuzo-guattariano, mormente no campo educacional. Intenta-se, assim, contribuir com discussões metodológicas em educação com o interesse de, a partir da filosofia de Deleuze e Deleuze-Guattari, construir um ethos de pesquisa mais do que um método de pesquisa. Para tanto, apresenta-se um panorama das apropriações dessa ideia de experimentação pela pesquisa educacional brasileira contemporânea para, na sequência, aprofundar-se a discussão sobre a relação das noções de prudência e experimentação em Capitalismo & Esquizofrenia. Debruçamo-nos sobre o método de trabalho próprio de Deleuze e Guattari, com vistas a extrair problematizações metodológicas que poderão ser estratégicas aos pesquisadores, no que tange aos modos de enfrentamento de problemas, em educação.
Gestão curricular inclusiva e formação de professores do 2.º Ciclo do Ensino Básico em Portugal
Authors: Inês Helena , Seabra Filipa , Pacheco José-Augusto
Published: July 2022

O presente artigo incide num estudo sobre perceções dos coordenadores de cursos de formação inicial de professores do 2.º Ciclo do Ensino Básico (CEB), em particular sobre a forma como os cursos que coordenam preparam os futuros professores para o trabalho com alunos que evidenciam dificuldades de aprendizagem e necessitam de medidas de educação inclusiva. A questão formulada – De que modo coordenadores de cursos de formação inicial de professores do 2.º CEB percecionam a diferenciação curricular e pedagógica em função do trabalho com alunos que necessitam de um apoio pedagógico específico? – faz parte de um projeto de investigação mais amplo, sendo apresentados, neste texto, os resultados de um estudo empírico de natureza qualitativa. Os dados foram recolhidos através de inquérito por entrevista, realizado a coordenadores (n=5) de cursos de ensino superior português público (quatro universidades e um instituto politécnico). Os resultados evidenciam que os coordenadores em estudo identificam um processo de melhoria na formação inicial de professores e na área específica da gestão curricular baseada na diversidade, que envolve alunos com dificuldades de aprendizagem ou incapacidades, pelo que as suas conceções se revelam favoráveis à relevância da inclusão, ancorada numa revisão mais abrangente da formação inicial de professores.
bem-estar subjetivo das crianças em tempos de confinamento
Authors: Barra Marlene , Fernandes Natália , Sani Ana Isabel
Published: July 2022

A crise pandémica que vivemos, motivada pela disseminação da COVID-19, tem tido um alcance massivo que não conhece fronteiras, acarretando sentimentos de vulnerabilidade e insegurança que trespassam classes sociais e grupos geracionais. No caso da infância, as situações de crise são particularmente impactantes no exercício dos seus direitos básicos. Conscientes desta realidade, consideramos ser fundamental recentrar a reflexão e contribuir com conhecimento produzido a partir das vozes das crianças, que nos permita caracterizar o seu bem-estar subjetivo em tempos de pandemia. Para tal, apresentaremos uma reflexão sobre a infância e o conceito de bem-estar subjetivo, a qual nos apoiará na análise dos dados resultantes de uma pesquisa, que teve como objetivo, precisamente, caracterizar o bem-estar subjetivo das crianças em tempos de pandemia. Para o efeito, foi desenvolvido online um “Questionário sobre o bem-estar das crianças em tempo de pandemia”, tendo em vista aceder às perceções das crianças relativamente às dimensões da saúde, educação, relacionamentos com familiares e pares e satisfação com a vida. Cumulativamente, em parceria com a “Rádio Miúdos”, foram também realizados “Debates Temáticos” com as crianças sobre a situação pandémica. A partir da análise e discussão dos dados obtidos, é possível divulgar conhecimentos sobre a sua vida quotidiana, entre crianças, na família e na comunidade, e promover a compreensão das suas convicções, do seu grau de satisfação com o meio e com as relações que mantêm em situação de pandemia.
Analisis Kebijakan PSBB dalam Proses Pembelajaran di PAUD Terpadu Az-Zahra Tegalrejo Yogyakarta
Authors: Nurakhmaliyah Siti , Mawardi Imam
Published: July 2022

Tujuan penelitian ini adalah untuk memaparkan informasi terkait proses pembelajaran di Paud terpadu Az-Zahra terkait dengan adanya kebijakan PSBB yang diterapkan pemerintah melalui surat keputusan bersama empat kementerian tentang Proses pembelajaran jarak jauh yang dikarenakan terjadinya Covid-19 yang melanda hampir seluruh Negara belahan dunia, tak terkecuali di Indonesia. Penelitian ini merupakan penelitian kualitatif dengan pendekatan kepustakaan dan pengumpulan data menggunakan hasil dokumentasi, buku referensi dan juga jurnal ilmiah yang berkaitan dengan topik. Hasil penelitian ini mengungkapkan bahwa dalam menjalankan kebijakan pembelajaran akibat pandemic covid 19 PAUD Terpadu Az-Zahra menerapkan langkah-langkah yaitu: (1) Dalam proses pembelajaran secara online akan diinformasikan melalui grup whatsapp pada masing-masing kelas yang diampu setiap guru, (2) Guru akan membuat video pembelajaran sebagai penguatan dalam tugas yang akan dilakukan anak bersama orangtua di rumah (3) Orangtua mengambil bahan kreativitas kegiatan anak di sekolah setiap hari senin, (4) Orangtua mengumpulkan hasil kreativitas anak atau dokumentasi kegiatan anak selama belajar dari  rumah dengan mengirimkan photo atau video ke WhatsApp Group kelas masing-masing, dan  (5) Bagi orangtua yang tidak berkenan untuk pembelajaran online guru datang ke rumah (home visit)  sesuai dengan jadwal yang disepakati bersama. Terdapat faktor penghambat yang lebih banyak dalam mengimplementasikan proses pembelajaran baik secara online maupun home visit daripada faktor pendukungnya.
Technology Application among Teachers from Rural Schools in Johor
Authors: Musa Mohd Hafizan , Abd Aziz Nurul Aien , Abd Aziz Noreen Noor , Mohamad Khalid Rusnani , Abdul Malik Shaherah , Nasution ST MKom Nurliana
Published: July 2022

The COVID-19 pandemic has disrupted the world’s education system, including Malaysia. This disruption has affected approximately 1.6 billion students in more than 200 countries. The closure of educational institutions has caused various changes in people’s lives. This research examines the associations between institutional support, perceptions of usefulness, personal innovation, perceived social pressure, and age with the application of technology among teachers from rural schools in Johor. One hundred ten teachers were involved in this study. The results showed that perceived usefulness, personal innovativeness, and perceived social pressure had influenced technology adoption among the teachers from rural schools.
Keywords: Technology application, e-learning, teaching and learning process
eISSN: 2398-4287© 2021. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3303
Women's Economic Empowerment and Protection Social Rights in Preventing Domestic Violence
Authors: Ahmad Nadzrah , Mohd Yusoff Rahmawati , Abdul Quddus
Published: July 2022

Gender equality in terms of economic participation and social standing of women appears to have contributed to violations of women's rights. This paper aims to examine the economic empowerment of women in Malaysia, preserve their social rights in the face of domestic violence, and propose a framework as part of the Malaysian Government's inclusive development. The analysis is based on a qualitative and descriptive cross-sectional study. The research found that prejudice and oppression against women are not sufficiently addressed in Malaysia due to low economic participation and insufficient observance of social rights.  
Keywords: Women Empowerment; Economy Involvement; Social Rights; Domestic Violence.
eISSN: 2398-4287 © 2022. The Authors. Published for AMER ABRA cE-Bs by e-International Publishing House, Ltd., UK. This is an open access article under the CC BYNC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). Peer–review under responsibility of AMER (Association of Malaysian Environment-Behaviour Researchers), ABRA (Association of Behavioural Researchers on Asians/Africans/Arabians) and cE-Bs (Centre for Environment-Behaviour Studies), Faculty of Architecture, Planning & Surveying, Universiti Teknologi MARA, Malaysia.
DOI: https://doi.org/10.21834/ebpj.v7i20.3395