bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical and Radiographic Outcomes of a one-stage lateral Sinus lift using Sticky Bone: A 4 years retrospective study.
Authors: Albash Ziad , Khalil Ali , Yousef Charl
Published: July 2023

Purpose
The aim of this study was to evaluate the clinical and radiographic outcomes of using sticky bone in lateral sinus lift procedures with simultaneously dental implants placement, and to compare the clinical and radiographic outcomes between perforated group and non-perforated group.
Methods
This retrospective study was carried out on patients who had reported to department of oral and maxillofacial surgery at Tishreen university between September 2018 and September 2022. The sample consisted of patients who had lateral sinus lift with simultaneous dental implants placement. Lateral sinus floor elevation procedures were performed using sticky bone (injectable platelet rich fibrin mixed with bovine graft material). Bone height were analyzed using CBCT scan that were taken preoperatively and 9 months postoperatively. Statistical analysis were performed to assess initial bone height (IBH), bone height after 9 months, intra-sinus bone gain (IBG). Intra-sinus bone gain outcomes were compared between perforated and non-perforated groups with unpaired t-test.
Results
A total of 21 implants were placed and 15 lateral sinus augmentation were performed using sticky bone in 15 patients were included in the study. four membrane perforations were observed Of 15 procedures (26.6%). The survival rate for all implants was 100%. The main of intra-sinus bone gain was 5.54 ± 0.74 mm. No statistically significant difference in intra-sinus bone gain between perforation group and non-perforation group (P > 0.001).
Conclusions
According to the result of this Study, sticky bone as a graft material can be utilized to achieve bone graft survival and sinus augmentation success in lateral sinus lift procedures with simultaneous dental implants placement, even following small and medium Schneiderian membrane perforations (< 10 mm).
Classification of likely functional state for ligand binding sites identified from fragment screening
Authors: Utgés Javier S. , MacGowan Stuart A. , Ives Callum M. , Barton Geoffrey J.
Published: July 2023

Fragment screening data from 37 experiments, and 1,309 protein structures binding to 1,601 ligands were analysed. A new method to group ligands by binding sites was developed and sites clustered according to profiles of relative solvent accessibility. This identified 293 unique ligand binding sites, which are grouped into four clusters (C1-4). C1 presents larger, more buried, conserved, and missense-depleted sites, and is enriched in known functional sites. C4 comprises smaller highly accessible, more divergent, missense-enriched sites, and is depleted in functional sites. A site in C1 is 28 times more likely to be functional than a site in C4. 17 novel sites in 13 proteins are identified as likely to be functionally important with examples from human tenascin and 5-aminolevulinate synthase discussed in more detail. An artificial neural network, and a K-nearest neighbours model are presented to predict cluster labels for new ligand binding sites with an accuracy of 96% and 100%, respectively so allowing functional classification of sites for proteins not in this set. Our findings will be of interest to those studying protein-ligand interactions and developing new drugs or function modulators.
The RISES System: An Innovative and Activity-Based Closed-Loop Platform for Spinal Cord Injury Rehabilitation and Recovery
Authors: Madarshahian Shirin , Guerrero Tatiana , Aung Phyo Thuta , Gustafson Kristin , Harrop James S. , Johnson Dana R. , Khantan Mehdi , Lee Yunsoo , Matias Caio , McCurdy Michael , Mulcahey MaryJane , Napoli Alessandro , Vaccaro Alex , Serruya Mijail
Published: July 2023

As spinal cord injury disrupts the communication between neural circuitry, electrical stimulation of the spinal cord may improve the rewiring and recovery of the affected pathways. Although significant recovery was initially observed in invasive implantable epidural stimulation settings, recent advancements in non-invasive transcutaneous spinal cord stimulation have shown the potential for significant improvements in individuals living with Spinal Cord Injury. In this study, we introduce the Reynolds Innovative Spinal Electrical Stimulation (RISES) technology which is an innovative person-tailored and task-specific stimulation system intended to optimize stimulation parameters in real-time with its multi-data acquisition and closed-loop capabilities. We aimed to pilot the safety and feasibility of the RISES system by implementing the developed technology as part of an intervention modeled on clinical rehabilitation. The results confirmed that the technology was able to establish a framework for achieving safe and feasible neurological recovery evident in enhancements of muscle activation for proximal muscles, and without any indication of physiological adverse effects.
Task-dependent pitch auditory feedback control in cerebellar ataxia
Authors: Hilger Allison , Cole Jennifer , Larson Chuck
Published: July 2023

Purpose
The purpose of this study was to investigate how ataxia affects the task-dependent role of pitch auditory feedback control in speech. In previous research, individuals with ataxia produced over-corrected, hypermetric compensatory responses to unexpected pitch and formant frequency perturbations in auditory feedback in sustained vowels and single words (Houde et al., 2019; Li et al., 2019; Parrell et al., 2017). In this study, we investigated whether ataxia would also affect the task-dependent role of the auditory feedback control system, measuring whether pitch-shift responses would be mediated by speech task or semantic focus pattern as they are in neurologically healthy speakers.
Methods
Twenty-two adults with ataxia and 29 age- and sex-matched control participants produced sustained vowels and sentences with and without corrective focus while their auditory feedback was briefly and unexpectedly perturbed in pitch by +/−200 cents. The magnitude and latency of the reflexive pitch-shift responses were measured as a reflection of auditory feedback control.
Results
Individuals with ataxia produced larger reflexive pitch-shift responses in both the sustained-vowel and sentence-production tasks than the control participants. Additionally, a differential response magnitude was observed by task and sentence focus pattern for both groups.
Conclusion
These findings demonstrate that even though accuracy of auditory feedback control correction is affected by cerebellar damage, as evidenced by the hypermetric responses, the system still retains efficiency in utilizing the task-dependent role of auditory feedback.
Comparison of cathodic protection of EC/ZRCs on defective areas under atmospheric and immersion conditions: secondary activation of zinc particles
Authors: Chen Zhiwei , Zhang wei , Xia Wenting , Zhang Guoqing , Qian Sicheng , Lin Zhifeng
Published: July 2023

The cathodic protection of epoxy coating/epoxy zinc-rich coatings on the defective areas under atmospheric and immersion conditions was studied via wire beam electrode, scanning electron microscopy, X-ray diffraction, and surface morphology analysis. The results showed that the cathodic protection processes under the two test conditions displayed significant differences. The effective protection time of the defective area under the atmospheric condition was 1.7 times that under the immersion condition. Compared with the immersion condition, zinc particles in zinc-rich coatings under atmospheric conditions exhibited higher cathodic protection efficiency. The possible activation mechanism of zinc particles under the two conditions was elucidated.
A modified two-switch SEPIC converter and its efficient switching function for grid-connected PV Applications
Authors: L Hubert Tony Raj , Nadar Edward Rajan Samuel
Published: July 2023

This paper shows a non-isolated modified two switch single-ended primary converter (SEPIC) using voltage multiplier cells. In addition to increasing voltage gain, lowering the duty cycle, and minimising voltage stress across the switches, the proposed enhanced SEPIC converter is made to provide a steady current at the input. The converter will be suited for renewable energy applications due to these enhancements. The proposed two-switch modified SEPIC converter (TSMSC) is validated in this paper by analysing its operation in continuous conduction mode (CCM) and discontinuous conduction mode (DCM). The proposed converter is evaluated against other converters based on a review of its operating modes. The MATLAB simulation is done for 200 W, 20 V/200 V and 50 kHz set up to evaluate the proposed converter. Using the results of MATLAB simulations, the performance of the proposed converter is assessed and validated. This paper also indicates maximum power tracking in a photovoltaic (PV) system using a two-switch modified SEPIC converter and a fuzzy logic controller (FLC). The maximum amount of electricity generated by the PV module is regulated by the fuzzy logic controller. Maximum power point tracking (MPPT) in PV systems under changing irradiation circumstances is described, along with comparisons to the perturbation and observation (P&O) method.
Identification of routes contaminated by industrial processes
Authors: Osornio-Berthet L. J. , Melendez-Estrada J. , García-Martinez M. , Cruz-Castro O. , Gomez-Nuñez J. , Beltrán-Rocha J. C.
Published: July 2023

The present paper shows an innovative methodology for the detection of potentially contaminated routes through a varied analysis depending on the occurrence and frequency in a specific place. One of the tools used is the Geographic Information System (GIS), which was used for the analysis and identification of industrial routes from which pollutants potentially harmful to health are derived. These industries are classified according to the pollutants whose emissions and effluents vary according to the economic line of business; they were also classified according to the number of people working in them. To calculate the area susceptible to contamination and the population exposed, the main roads (canals, tributary rivers) affected by these discharges were located. The case study is the José Antonio Alzate dam, one of the most important dams in Mexico, which is going through one of the worst stages in its history due to the excessive amount of toxic waste discharged into the José Antonio Alzate river and some tributaries. In the present paper were identified qualitatively and quantitatively 567 industries whose activities directly affect approximately 2.5% of the population, as well as the polluting routes.
Association between plasma proteome and glioma: A two-sample Mendelian randomization analysis
Authors: Xie Zhihao , Xu Meng , Wang Wentao , Wang Lei , Wang Chongcheng
Published: July 2023

Purpose
Glioma is the most common malignant tumor in the central nervous system, and patients generally have a poor prognosis. Biomarker research can help improve early diagnosis and treatment of gliomas. As plasma proteins can sample of the body's health status and is easy to access, it has become promising biomarkers for gliomas. Our objective is to explore the association between plasma proteins and glioma and to identify new therapeutic targets and biomarkers for glioma.
Methods
We used pQTLs of plasma proteins from the INTERVAL and Icelanders’ cohorts as instrumental variables and conducted Two-sample Mendelian randomization analyses using five models (Wald ratio, IVW, MR-Egger, Weighted Median, MRPRESSO).
Results
The results showed that 13 plasma proteins (CHST9, RACGAP1, IL18R1, FCRL3, ERAP1, GRN, MLN, TDGF1, SIRPB1, C1QTNF1, TAPBPL, TMPRSS11D, TPST2) had a causal relationship with gliomas, with five being risk factors (SIRPB1, RACGAP1, MLN, CHST9, TPST2) and eight being protective factors (TMPRSS11D, C1QTNF1, GRN, IL18R1, FCRL3, TAPBPL, ERAP1, TDGF1). Many of these are reported for the first time. Reverse Mendelian randomization analysis showed that there was no reverse causality between those proteins and glioma.
Conclusion
Our study reports multiple biomarkers for gliomas, which may provide some reference for the diagnosis and treatment of gliomas and future research.
Magnetar emergence in a peculiar gamma-ray burst from a compact star merger
Authors: Zhang Binbin , Sun Hui , Wang C.-W. , Yang Jun , Xiong Shaolin , Yin Yi-Han , Liu Yuan , Li Ye , Xue W.C. , Yan Z.-Y. , Zhang C. , Tan W.-J. , Pan H.-W. , Liu Jia-Cong , Cheng H.-Q. , Zhang Yan-Qiu , Hu J.-W. , Zheng Chao , An Z.-H. , Cai C. , Hu Lei , Jin C. , Li D.-Y. , Li Xin , Liu H.-Y. , Liu M. , Peng W.X , Song Liming , Sun S.-L , Sun X.-J , Wang X.-L. , Wen X.Y. , Xiao S. , Yi S.-X. , Zhang F. , Zhang W.-D. , Zhang X.-F. , Zhang Y.-H , Zhao D.-H. , Zheng S.J. , Ling Z.-X. , Zhang Shuang-Nan , Yuan Weimin , Zhang Bing
Published: July 2023

The central engine that powers gamma-ray bursts (GRBs), the most powerful explosions in the universe, is still not identified. Besides hyper-accreting black holes, rapidly spinning and highly magnetized neutron stars, known as millisecond magnetars, have been suggested to power both long and short GRBs1–7. The presence of a magnetar engine following compact star mergers is of particular interest as it would provide essential constraints on the poorly understood equation of state for neutron stars8, 9. Indirect indications of a magnetar engine in these merger sources have been observed in the form of plateau features present in the X-ray afterglow light curves of some short GRBs10, 11. Additionally, some X-ray transients lacking gamma-ray bursts (GRB-less) have been identified as potential magnetar candidates originating from compact star mergers6, 12, 13. Nevertheless, smoking gun evidence is still lacking for a magnetar engine in short GRBs, and the associated theoretical challenges have been addressed14. Here we present a comprehensive analysis of the broad-band prompt emission data of a peculiar, very bright GRB 230307A. Despite its apparently long duration, the prompt emission and host galaxy properties point toward a compact star merger origin, being consistent with its association with a kilonova15. More intriguingly, an extended X-ray emission component emerges as the γ-ray emission dies out, signifying the emergence of a magnetar central engine. We also identify an achromatic temporal break in the high-energy band during the prompt emission phase, which was never observed in previous bursts and reveals a narrow jet with half opening angle of approximately 3.4◦.
Numerical investigation of multi-nozzle ejector device with inclined nozzles for marine gas turbine
Authors:   College of Energy & Power Engineering, Jiangsu University of Science and Technology, Shi Hong , Zheng Rentong , Zhang Qianwei , Yuan Jie , Wang Rui , Cheng Mengmeng , Zou Yitao
Published: July 2023

The high-temperature exhaust gases and the hot surfaces of the ejector device in marine gas turbines generate significant levels of infrared radiation. An appropriate nozzle structure can effectively lower the exhaust gas temperature and reduce the high-temperature radiation surface area, thereby minimizing external infrared radiation. In this study, a numerical simulation of the nozzle structure in the ejector device was conducted using computational fluid dynamics (CFD) methods. By investigating the orthogonal combinations of nozzle inclination angles and the number of nozzles, the temperature distribution and flow characteristics under different operating conditions were analysed. The results showed that as the nozzle inclination angle increased, the entrainment coefficient (Ce) and the temperature ratio at the inlet and outlet (Rt) initially improved but then worsened. Simultaneously, the pressure loss coefficient (Cpl) increased with the inclination angle. The CRITIC weight method was employed to objectively allocate weights to Rt, Ce, and Cpl, determining the optimal solution. The results indicated that Rt and Cpl had significant and similar weights. The optimal solution was found in Case 10 (α = 5°, x = 4), with corresponding evaluation indices of Ce=2.38, Cpl=11.45, and =0.68. This study's findings are of great importance for enhancing the performance of marine gas turbines and reducing external infrared radiation.
Examining the Residential Mobility Patterns and Mobility Factors of Elderly Households: Single and Couple Households Living in the Seoul Metropolitan Region
Authors:   Korea Urban & Real Estate Association, Park Hwan-Su , Lee Jae-Su
Published: July 2023

In 2020, there were 1,060.0 ten thausand households in the Seoul metropolitan region, accounting for 49.3% of all households in Korea, and a total of 4,166.0 ten thausand households have moved within the Seoul metropolitan area over the past 20 years, excluding the same city, county, and district. Among them, a total of 227.0 ten thausand households moved to one person aged 65 or older or elderly couples. The reason why elderly households, which account for 5.4% of all households in housing movement, are important is that Korea has a fast low birth rate and aging rate, and a super-aging society is expected in 2025. Recently, it was reported that Korea also has the fastest rate of low birth rate and aging among OECD countries. This is also the reason why interest and discussion on elderly households are needed, and housing is an indispensable issue among welfare policies. In general, elderly households aged 65 or older can be viewed as single-person households due to divorce or bereavement after their adult children are separated, and they need to analyze where, how much, and why they move their housing. This shows how housing consumption is being adjusted from the perspective of consumers, not suppliers, by observing various perspectives on housing policies for elderly households.
COMPARISON OF DEXMEDETOMIDINE AND CLONIDINE AS AN ADJUVANT TO BUPIVACAINE IN SCALP BLOCK FOR SUPRATENTORIAL CRANIOTOMY SURGERY - A PROSPECTIVE, RANDOMISED INDIAN STUDY
Authors:   1,1stfloor,Oppositeomkardarshan,Masolital-Dahanudist-Palghar 401602., Madhukar Panchal Shrikant , S Gosavi Kundan ,   Anesthseia Department, Main Building,6th floor, JJ Hospital Campus, Byculla, Mumbai,400008., R. Kudre Krupali ,   1,1stfloor,Oppositeomkardarshan,Masolital-Dahanudist-Palghar 401602.
Published: July 2023

Background: Current era of minimally invasive surgery and awake craniotomy has created revived attention towards scalp blocks and its benefits. Present study was conducted to evaluate and compare effects of dexmedetomidine and clonidine as an adjuvant to bupivacaine in scalp block for supratentorial craniotomy surgery. Methods: The prospective, comparative, randomized study was conducted by Department of Anaesthesia at J.J. Hospital and Grant Medical College, Mumbai, India. Data was collected between September 2018 to August 2020. Adult subjects between 18 years and 60 years (both inclusive) of either gender with ASA-I, Glasgow Coma Scale (GCS) of 15, and indicated to undergo supratentorial craniotomy surgeries were enrolled. One study group received 1 mcg/kg Clonidine, while other 1 mcg/kg Dexmedetomidine, both diluted with normal saline. Hemodynamic parameters, analgesic requirement and Ramsay Sedation score (RSS) were assessed. Results: 60 patients (30 in each group) were enrolled. Mean age, baseline weight, gender distribution and duration of surgery were statistically comparable between study groups (P>0.05). Mean blood pressure, mean arterial pressure and heart rate were significantly higher in the clonidine group at the time of pin insertion, incision and during most of the intraoperative period (p<0.05). RSS was comparable between study groups at all time-points (p>0.05). Analgesic requirement was overall higher in clonidine group, indicating better analgesia with Dexmedetomidine. Conclusion: Dexmedetomidine led to lesser vascular parameters changes, with lower analgesic requirement versus clonidine however, sedation scores were comparable.
MANAGEMENT OF VATARAKTA WITH VIRECHANA KARMA - A CASE REPORT
Authors:   PG Scholar, DepartmentofPanchakarma, Dr. BRKR Government Ayurvedic College & Hospital, Hyderabad- 500018., Ravali K. , K. Madikonda Praveen ,   Associate Professor, DepartmentofPanchakarma, Dr. BRKR Government Ayurvedic College & Hospital, Hyderabad- 500018., Johar HOD B. ,   Professor, DepartmentofPanchakarma, Dr. BRKR Government Ayurvedic College & Hospital, Hyderabad- 500018.
Published: July 2023

Vatarakta is metabolic and also a life style disorder of todays world which is rising rapidly.It is a VatapradhanaTridoshajVyadhi caused by both, VataDosha and RaktaDushtiand therefore is called Vatarakta.Here is a single case report of 30 years old male patient approached the OPD of Government Ayurvedic hospital, Hyderabad, with chief complaints of severe pain in Metacarpo-phalangeal, Metatarso-phalangeal, wrist and ankle jointwith stiffness+++ more than 1hour, tenderness+++, sleeplessness due to pain, swelling of more than two joints along with moderate blackish discolouration. All the above complaints were present since 4months. The patient was given panchakarma therapy, in the form ofVirechanakarma withKalyanakagrita as a Snehapanafollowed bysamsarjanakrama. After 20 days of treatment patient got a significant symptomatic relief, which was relatable to the reduction in the level of serum uric acid in blood.In case of Vatarakta, though Vasti, Raktamokshana and many palliative measures are indicated to remove the accumulated excess doshas from the body,Virechanakarma can be considered due to its quick &effective results.
NATURAL PRODUCTS: USED AS TRADITIONAL MEDICINE
Authors:   St. Josephs College For Women, Civil Lines, Gorakhpur, U.P., India., Kumar Singh Krishna
Published: July 2023

Plants have provided man with all his needs in terms of shelter, clothing, food, flavours and fragrances as not the least, medicines. Plants have formed the basis of sophisticated traditional medicine systems among which are Ayurvedic, Unani, Chinese amongst others. These systems of medicine have given rise to some important drugs still in use today. The search for new molecules, nowadays, has taken a slightly different route where the science of ethnobotany and ethnopharmacognosy are being used as guide to lead the chemist towards different sources and classes of compounds. It is in this context that the flora of the tropics by virtue of its diversity has a significant role to play in being able to provide new leads.
Evaluation of historical CMIP6 model simulations and future climate change projections in the Baro River Basin
Authors: Gebisa Bekele Terefe , Dibaba Wakjira Takala , Kabeta Alemayehu
Published: July 2023

This study evaluated the performance of five Global Climate Model (GCM) outputs from the Coupled Model Intercomparison Project phase 6 (CMIP6) in reproducing the historical precipitation and temperature. Observational data from the National Meteorological Agency are used for model evaluation and bias correction. Then, the projections from representative GCMs are used to understand the future climate (2031–2060) of the Baro River Basin under two Shared Socioeconomic Pathways (SSP2-4.5 and SSP5-8.5) with respect to the historical datasets (1985–2014). Statistical metrics (percent of bias, root mean square error, and coefficient of determination) are used to assess the model's performance in reproducing precipitation and temperature and Compromise Programming (CP) was used in ranking GCMs. GFDL-CM4, INM-CM5-0, and INM-CM4-8 models for precipitation; CMCC-ESM2, MRI-ESM2-0, and INM-CM4-8 for maximum temperature; and GFDL-CM4, INM-CM4-8, and INM-CM5-0 for minimum temperature were selected based on their better simulation. The projected annual precipitation shows increases of 6% under SSP2-4.5 and 16.46% under SSP5-8.5. The mean annual maximum and minimum temperature show increases of 1.43 and 1.96 °C under SSP2-4.5, and 1.81 and 3.11 °C under SSP5-8.5, respectively. Overall, the ensemble of three models outperforms the ensemble of all models for the Baro River Basin when utilising the representative GCMs.
Establishing the optimal condition for nutrient recovery from domestic wastewater using the freeze concentration method
Authors: Muga Elly Chimoto , Komakech Hans Charles , Jande Yusufu Abeid-Chande
Published: July 2023

The freezing concentration method is one of the potential techniques for recovering nutrients from wastewater. In this study, the method of freeze concentration was studied to establish its optimal conditions in recovering nitrate-nitrogen and phosphate nutrients from domestic wastewater. Water in the form of an ice crystal block is produced and leaves behind a solution with a higher concentration. The effects of coolant temperature from −10 to −80 °C, freezing time from 1 to 8 h, and energy consumption on nutrient recovery were investigated. The optimal conditions were found at a coolant temperature of −20 °C, freezing time of 7 h, and energy consumption of 0.197 kWh/L that resulted in the highest nitrate-nitrogen and phosphate nutrient recovery values of 1.114 and 4.667, respectively, at the inlet of anaerobic digester 1; 1.325 and 4.975, respectively, at the outlet of anaerobic digester 1; 1.099 and 4.859, respectively, at the inlet of anaerobic digester 2; 1.132 and 4.755, respectively, at the outlet of anaerobic digester 2; and for gravel filter at the outlet the values were 1.111 and 4.861, respectively. The recovered nutrients can be used as biofertilizers.
Evaluation of the sensitivity of the RUSLE erosion model to rainfall erosivity: a case study of the Ksob watershed in central Algeria
Authors: Sakhraoui Fouad , Hasbaia Mahmoud
Published: July 2023

Water erosion is a serious challenge in Algeria, because it affects ecosystems, contributes to soil degradation, and leads to the silting of dams; moreover, this process is complex and needs costly field equipment and trip reconnaissance. The main objective of this paper is to evaluate the sensitivity of the Revised Universal Soil Loss Equation (RUSLE) model to rainfall erosivity in the Ksob watershed in Algeria, using six empirical formulas of rainfall erosivity. The RUSLE model with the Geographic Information System (GIS) produces highly variable specific soil loss ranging from 11.35 to 22.85 t ha−1 year−1 throughout the watershed, depending on the erosivity R factor. To validate the results, the soil loss is compared with the silting volume data of the Ksob dam, which is located at the outflow of the basin. The best result is obtained using the Diodato R factor formula with a relative error of 21% and a specific soil loss of 11.35 t ha−1 year−1. Moreover, over 81% of the watershed area is exposed to low erosion (<20 t ha−1 year−1), and less than 5% are affected by high erosion (>50 t ha−1 year−1).
The Association of the Spatial Location of Contrast Extravasation with
Symptomatic Intracranial Hemorrhage after Endovascular Therapy in
Acute Ischemic Stroke Patients
Authors: Gong Chen , Wang You , Yuan Jinxian , Zhang Jie , Jiang Shuyu , Xu Tao , Chen Yangmei
Published: July 2023

Background:

Contrast extravasation (CE) on brain non-contrast computed tomography
(NCCT) after endovascular therapy (EVT) is commonly present in patients with acute ischemic stroke
(AIS). Substantial uncertainties remain about the relationship between the spatial location of CE and
symptomatic intracranial hemorrhage (sICH). Therefore, this study aimed to evaluate this association.

Methods:

We performed a retrospective screening on consecutive patients with AIS due to LVO
(AIS-LVO) who had CE on NCCT immediately after EVT for anterior circulation large vessel occlusion
(LVO). We used the Alberta stroke program early CT Score (ASPECTS) scoring system to
estimate the spatial location of CE. Multivariable logistic regression was performed to achieve the
risk factors of sICH.

Results:

In this study, 115 of 153 (75.1%) anterior circulation AIS-LVO patients had CE on
NCCT. After excluding 9 patients, 106 patients were enrolled in the final analysis. In multivariate
regression analysis, atrial fibrillation (AF) (adjusted OR [aOR] 6.833, 95% confidence interval
[CI] 1.331-35.081, P = 0.021) and CE-ASPECTS (aOR 0.602, 95% CI 0.411-0.882 P = 0.009)
were associated with sICH. In subgroup analysis, CE at the internal capsule (IC) region was an
independent risk factor for sICH (aOR 5.992, 95% CI 1.010-35.543 P < 0.05). These and conventional
variables were incorporated as a predict model, with AUC of 0.899, demonstrating good
discrimination and calibration for sICH in this study cohort.

Conclusion:

The spatial location of CE on NCCT immediately after EVT was an independent and
strong risk factor for sICH in acute ischemic stroke patients.
An Introduction to Regulatory Aspects Related to Medical Devices in Japan and
Canada
Authors: Sharma Yashika , Singh Dilpreet , Singh Amrinder
Published: July 2023

Background:

A medical device is a gadget that is used to identify, prevent, or treat illness or other medical conditions, but it does not work chemically on or within the body. It includes instruments, apparatus, implants, in vitro reagents, and similar or related items. The approval process for medical equipment in regulated markets (such as those in Canada and Japan) is one of the major concerns for their proper induction. The categorization of medical equipment and the procedure for their approval in these nations and their companions need to be clearly addressed in order to facilitate a better understanding of the regulations.

Aim:

The regulatory considerations regarding the Japanese regulatory body for medical devices have been well discussed. Further, other aspects, such as the organization of the study of medical devices and the clearance process with the Ministry of Health, Labour, and Welfare's role in Japan's medical device industry, have been elaborated. Medical device licensing and application procedures in this regard with the leading Japanese medical equipment manufacturers have been revealed.

Results/Discussion:

In Canada, medical equipment post-market surveillance on risk-based categorization has been revealed. The organisational structure of the medical equipment governing body and the Canadian approval process for medical instruments included by Health Canada with the top 10 medical technology setups in Canada have been elaborated in detail.

Conclusion:

In this review, regulatory aspects in Japan and Canada for understanding the direction and evolution of the medical device industry have been discussed. This analysis aims to provide a more comprehensive understanding of the regulatory framework governing the marketing authorisation of diagnostic and therapeutic medications in Japan and Canada to a global audience.
Packaging Materials Design And Developing Trend
Authors: Zheng Xiaojing
Published: July 2023

Packaging materials design is related to economic and social development. At the same
time, it also reflects human aesthetic and emotional expression. With the continuous maturity of
consumer psychology, people have a new understanding of packaging design, and the past packaging
materials design concepts can no longer meet the various needs of customers. As is known,
packaging plays a very important role in promoting products to customers. Therefore, attractive
packaging materials design is essential. In this work, the developing history of packing materials
design was reviewed in detail. Both the advantages and disadvantages of the packing materials
were discussed. Packaging materials experienced the process from paper, plastic, and metal to
composite materials. The functions of packaging materials have gone from single to comprehensive.
Driven by the commercialization of fierce competition, although humans have made great
achievements in packaging material design, there is still greater room for development in packaging
material design to meet the needs of future society. For a long time from now to the future, the
balance between practicality and aesthetics will still be the basic principle of material packaging
design. In addition, the human experience, such as the friction coefficient of packaging materials,
has begun to be considered. The artistic combination of materials, shapes, colors, and characters
combined with artificial intelligence has gradually become the frontier of packaging material design.
By learning from nature, it can be concluded that smart packaging, eco-friendly and sustainable
development in packaging materials design combining practicality and aesthetics are the developing
trend for the future.
Traditional Herbal Medicines: A Prospective Panacea for SARS-CoV-2
Authors: Jain Amul , Sharma Apoorva , Bais Sujata , Kaur Simran , Verma Aastha , Sinha Priyank , Gupta Bhanushree , Joshi Veenu , Sharma Rahul , Dubey Amit , Vyas Amber , Kumar Ghosh Kallol
Published: July 2023

The pandemic has trembled the world with the massive outbreak, leaving the
scientific fraternity in shambles. The SARS-CoV-2 strain took a heavy toll and led to
the death of millions of people. In late 2020, various mutated strains of the virus surged
the disease across the world. For the same, diverse methods were used around the globe
in search of precise medication against the pandemic. Despite vaccination for viral
disease prevention, the virus has spread without restraint, making the need for strong
antiviral drugs- a need of the hour. Several techniques were used for the fabrication of
a strong antiviral drug in different modes of remedies. Many countries utilized their
conventional therapeutic knowledge against the virus, which comprises the use of
indigenous phytochemicals with varied biological activities. The present review
includes the virology, epidemiology, and different therapeutic procedures practiced
globally to combat the viral disease and highlights different indigenous potent plants
with biological activities, such as antiviral, antipyretic, immunomodulatory and
antimicrobial. These plants are efficacious and can be explored further as prospective
remedies for many other maladies affecting the world.
Ethnobotany, Ethnomedicine, Chemistry and Pharmacology of Clematis Species Used in Australia, China and India
Authors: Malik Jai , David Lin G. , Smith Paul N. , Li Rachel W. , Chandra Mandal Subhash
Published: July 2023

Plants are the biggest bioresources for newer drugs or therapeutical agents.
Genus, Clematis of family Ranunculaceae is one such bioresource whose species have
been used traditionally for the treatment of snake bites, malaria, dysentery, rheumatism,
inflammation, urinary and skin disorders, blisters, wound, ulcers, colds and headaches
in Australia, China, India and other countries. Modern research revealed that Clematis
species possess pharmacological properties of anti-inflammatory, anti-rheumatoid
arthritis, anti-diabetic, anti-apoptosis, anticancer, antioxidation, antimicrobial,
hepatoprotection, diuretic and hypotensive. Genus Clematis has approximately 355
species that are spread across the globe. Chemical constituents isolated from different
species of this genus have been categorized under some of the biologically potent
phytochemical classes, such as alkaloids, triterpenoid saponins, lignans, flavonoids and
phytosterols, which may account for the pharmacological action. The present chapter
will focus on common species used in the Australian, Chinese and Indian traditional
systems of medicine. Their ethnobotany, ethnomedicine, chemical constituents and
pharmacological activities are critically reviewed.
Computer Simulation of Electric Drive with Induction Motor and Fluid Coupling
Authors: Pustovetov Mikhail , Shukhmin Konstantin , Goolak Sergey , Matijošius Jonas , Kravchenko Kateryna
Published: July 2023

A new approach to the shaft load simulation with the different types of fluid
coupling is introduced herein. The presented simulation results are obtained for an
electrohydrodynamic drive at different load modes and types of fluid coupling such as:
with constant filling; static self-emptying (traction fluid coupling) and dynamic self-emptying (limiting fluid coupling). The chapter also provides an example of fluid
coupling parameters and characteristics as well as depicts the following operation
modes of the system: acceleration; no-load; load and overload on the turbine shaft. 
Selected Information of the Auxiliary Electric Drive of an AC Electric Locomotive, Comprising Three-Phase Induction Motors, a Capacitive Phase Splitter and a Thyristor Frequency and Number of Phase Converted
Authors: Pustovetov Mikhail , Shukhmin Konstantin , Goolak Sergey , Matijošius Jonas , Kravchenko Kateryna
Published: July 2023

This chapter provides an electrical schematic diagram of the power circuits
of an auxiliary electric drive with a capacitive phase splitter and 3-phase induction
motors onboard of an AC electric locomotive and the statistics and root causes of
typical failures of the induction motors operating as part of such a circuit. A conclusion
is made about the expediency of simulating thermal processes in the auxiliary induction
motors.
Análisis bibliométrico de la investigación sobre innovación empresarial
Authors:   Universidad Nacional Autónoma de Honduras UNAH, Acosta-Tzin Jose Valdo , Raudales-Garcia Eli Vicente ,   Universidad Nacional Autónoma de Honduras UNAH, Aguilar-Hernández Pablo Alcides ,   Universidad Nacional Autónoma de Honduras UNAH
Published: July 2023

Introducción: La innovación empresarial es un factor determinante para alcanzar el éxito en el mercado, es un elemento clave para mantenerse competitivo o desaparecer, esta permite mejorar los procesos en la producción, crear nuevos productos o servicios. Objetivo: El propósito de esta investigación fue llevar a cabo un análisis bibliométrico de la producción científica relacionada con la innovación empresarial. Metodología: Este estudio tuvo un alcance descriptivo y utilizó la técnica de la bibliometría para analizar la producción científica relacionada con la innovación empresarial en la base de datos de Scopus. Se aplicaron operadores booleanos y una ecuación de búsqueda con el objetivo de mejorar la precisión de los resultados obtenidos. Resultados: Se evidencia que, el tema de estudio en el transcurso del tiempo presenta una tendencia moderada de crecimiento entre los años 2019-2020, siendo el Reino Unido el país con mayor producción científica, el articulo más citado y relevante es la autoría; Noordhoff C.S., Kyriakopoulos K., Moorman C., Pauwels P. y Dellaert B.G.C, asimismo la revista más prolífera según el análisis de Bradford es la Journal Of Technology Management And Innovation. Conclusión: Se concluye que la innovación empresarial es un tema de gran relevancia en las disciplinas administrativas tanto para la academia como para las organizaciones, ya que se trata de un elemento crucial para el éxito empresarial en un entorno cada vez más competitivo.
A new whitefly species, Aleuropleurocelus petenensis sp. nov. (Hemiptera: Aleyrodidae), from Guatemala
Authors: Carapia-Ruiz Vicente Emilio , Sánchez-Flores Oscar Ángel , García-Ochaeta José Francisco
Published: July 2023

A new species of whitefly, Aleuropleurocelus petenensis sp. nov. Carapia-Ruiz & García-Ochaeta, found on leaves of a plant belonging to the genus Acalypha (Euphorbiaceae) in Petén, Guatemala, is described based on characteristics of the pupa. This new species exhibits a black venter and has microtubercles on the subdorsal and submedian areas, whereas the most closely related species, A. mixtecus Carapia-Ruiz, presents a pale venter and has not microtubercles on the corresponding areas. In both species the transverse suture of the molt ends before the apparent margin and the dorsal surface presents folds; these features support the close relationship between these species. Microphotographs of morphological structures of the new species puparium are provided.
Spider diversity (Arachnida: Araneae) in two different coffee management systems and surrounding tropical forest during two contrasting seasons in Oaxaca, Mexico
Authors: García-García Miguel Ángel , Ibarra-Núñez Guillermo , Martínez-Martínez Laura , Santos-Moreno Antonio , Sánchez-García José Antonio
Published: July 2023

This study focuses on species richness, abundance, diversity, and seasonal variation of spiders in two coffee plantations with different crop management and a portion of tropical forest in two municipalities of La Costa region of Oaxaca, Mexico, using manual collection, foliage beating and pitfall traps. We collected 2,210 spiders belonging to 35 families, 100 genera and 146 species. The inventory includes 51 new species records for Oaxaca. Completeness values for two estimators indicate that the level of representation of inventories range from 68.25% to 78.44%, and the proportion of singletons range from 33.72% to 38.14%. Spider abundance in the rainy season was significantly lower than during the dry season. Spider abundance in the Tropical Forest was significantly lower than Monoculture site with the foliage beating method. Polyculture was the site with the lowest spider abundance with the pitfall traps. Rarefaction curves did not show significant differences in species richness between the sites and seasons. Hutcheson t-test showed that spider diversity was significantly lower in Monoculture than Tropical Forest during the rainy season. This study contributes to the knowledge of the arachnofauna of Mexico and particularly of the state of Oaxaca.
Analyzing the factors influencing the adoption of cloud computing by SMEs using the SEM approach
Authors: Ali Abdifatah Farah , Hassan Abdikarim Abi , Abdullahi Husein Osman , Abdulah Rusli Haji
Published: July 2023

Cloud computing (CC) represents a third-generation computing platform that offers numerous benefits, including faster data transactions, cost advantages, elasticity, flexibility, and pay-per-use models, among others. However, CC adoption in developing nations, such as Somalia, is impeded by various challenges. This study aims to investigate the factors influencing CC adoption in small to medium-sized enterprises (SMEs) in Somalia. Data was collected from 195 ICT officials and experts in the SME domain in Mogadishu, Somalia, and analyzed using structural equation modeling (SEM). The results revealed that cost savings, firm size, top management support, and regulatory support significantly influence CC adoption in SMEs. Conversely, security concerns and competitive pressure showed no significant relationship with CC adoption. This study contributes to the literature by examining the technology, organization, and environment (TOE) framework in the context of CC adoption and provides valuable insights to inform policymaking and promote CC adoption in developing nations. Nonetheless, the study's limitation lies in its narrow focus on Somalia, and the generalizability of the results to other developing nations may be limited.
Entanglement between an isolated qubit and a qubit in a cavity with Kerr media
Authors: Bashkirov E. K.
Published: July 2023

We found the exact solution for a model consisting of two dipole-coupled qubits, one of which is an isolated, and the other interacts with the thermal mode of a cavity with the Kerr medium. The results showed that Kerr nonlinearity may greatly enhance the degree of entanglement induced by a thermal field both for separable and entangled initial states of qubits. We also showed the possibility of the disappearance of the sudden death of entanglement for a model with a Kerr nonlinearity. Keywords: qubits, thermal field, Kerr nonlinearity, dipole-dipole interaction, entanglement, sudden death of entanglement.
Photocatalytic properties in the visible region of light of composite microparticles of Ti/TiN/TiO-=SUB=-2-=/SUB=- obtained by electric arc synthesis
Authors: Gadzhiev M. Kh.  , ‪Orudzhev F.F.‬  , Muslimov A.E.  , Ilyichev M.V.
Published: July 2023

Method of electric arc synthesis of composite microparticles metal-semiconductor-dielectric based on titanium, titanium nitride and rutile with productivity up to 10 g/min is proposed. Using diffraction and microscopic methods, the morphology and structural-phase composition of the synthesized microparticles were studied. Using the example of methylene blue degradation, the photocatalytic activity of synthesized microparticles in the visible radiation range was demonstrated and its possible mechanism was proposed. Keywords: titanium, rutile, titanium nitride, microparticles, photocatalysis, visible light.
Acceleration of chemical processes in aerosol
Authors: Fedoseev V. B.
Published: July 2023

The evolution of the state of aerosol droplets containing a reaction mixture with volatile components is accompanied by a change in the size and composition of the droplets, changes in the concentrations of reagents and the rates of chemical reactions. The methods of formal chemical kinetics and equilibrium thermodynamics describe size effects that lead to a significant acceleration of chemical processes in aerosols. The dependence of the rate of chemical processes on the initial size and composition of droplets, as well as on the composition of the gas phase, is described. The main regularities are modeled on the example of the condensation reaction of glycine with glucose (Maillard reaction). Keywords: aerosol, size effect, chemical kinetics, spray technology.
Large Language Models for Epidemiological Research via Automated Machine Learning: Case Study Using Data From the British National Child Development Study
Authors: Wibaek Rasmus , Andersen Gregers Stig , Dahm Christina C , Witte Daniel R , Hulman Adam
Published: July 2023

Background

Large language models have had a huge impact on natural language processing (NLP) in recent years. However, their application in epidemiological research is still limited to the analysis of electronic health records and social media data.

Objectives

To demonstrate the potential of NLP beyond these domains, we aimed to develop prediction models based on texts collected from an epidemiological cohort and compare their performance to classical regression methods.

Methods

We used data from the British National Child Development Study, where 10,567 children aged 11 years wrote essays about how they imagined themselves as 25-year-olds. Overall, 15% of the data set was set aside as a test set for performance evaluation. Pretrained language models were fine-tuned using AutoTrain (Hugging Face) to predict current reading comprehension score (range: 0-35) and future BMI and physical activity (active vs inactive) at the age of 33 years. We then compared their predictive performance (accuracy or discrimination) with linear and logistic regression models, including demographic and lifestyle factors of the parents and children from birth to the age of 11 years as predictors.

Results

NLP clearly outperformed linear regression when predicting reading comprehension scores (root mean square error: 3.89, 95% CI 3.74-4.05 for NLP vs 4.14, 95% CI 3.98-4.30 and 5.41, 95% CI 5.23-5.58 for regression models with and without general ability score as a predictor, respectively). Predictive performance for physical activity was similarly poor for the 2 methods (area under the receiver operating characteristic curve: 0.55, 95% CI 0.52-0.60 for both) but was slightly better than random assignment, whereas linear regression clearly outperformed the NLP approach when predicting BMI (root mean square error: 4.38, 95% CI 4.02-4.74 for NLP vs 3.85, 95% CI 3.54-4.16 for regression). The NLP approach did not perform better than simply assigning the mean BMI from the training set as a predictor.

Conclusions

Our study demonstrated the potential of using large language models on text collected from epidemiological studies. The performance of the approach appeared to depend on how directly the topic of the text was related to the outcome. Open-ended questions specifically designed to capture certain health concepts and lived experiences in combination with NLP methods should receive more attention in future epidemiological studies.