bluuebunny/crossref_metadata_2025 huggingface dataset:
RN181 is a tumour suppressor in gastric cancer by regulation of the ERK/MAPK–cyclin D1/CDK4 pathway
Authors: Wang Suihai , Wang Xiaobo , Gao Yanjun , Peng Yingxia , Dong Ningning , Xie Qian , Zhang Xian , Wu Yingsong , Li Ming , Li Ji‐Liang
Published: February 2019

RN181, a RING finger domain‐containing protein, is an E3 ubiquitin ligase. However, its biological function and clinical significance in cancer biology are obscure. Here, we report that RN181 expression is significantly down‐regulated in 165 tumour tissues of gastric carcinoma (GC) versus adjacent non‐tumour tissues, and inversely associated with tumour differentiation, tumour size, clinical stage, and patient's overall survival. Alterations of RN181 expression in GC cells by retrovirus‐transduced up‐regulation and down‐regulation demonstrated that RN181 functions as a tumour suppressor to inhibit growth of GC in both in vitro culture and in vivo animal models by decreasing tumour cell proliferation and increasing tumour cell apoptosis. Cell cycle analysis revealed that RN181 controls the cell cycle transition from G1 to S phase. Mechanistic studies demonstrated that RN181 inhibits ERK/MAPK signalling, thereby regulating the activity of cyclin D1–CDK4, and consequently controlling progression in the cell cycle from G1 to S phase. Restoring CDK4 in GC cells rescued the inhibitory phenotype produced by RN181 in vitro and in vivo, suggesting a dominant role of CDK4 in control of the tumour growth by RN181. Importantly, RN181 expression is inversely correlated with the expression of cyclin D1 and CDK4 in GC clinical samples, substantiating the role of the RN181–cyclin D1/CDK4 pathway in control of the tumour growth of GC. Our results provide new insights into the pathogenesis and development of GC and rationale for developing novel intervention strategies against GC by disruption of ERK/MAPK–cyclin D1/CDK4 signalling. In addition, RN181 may serve as a novel biomarker for predicting clinical outcome of GC. © 2019 The Authors. The Journal of Pathology published by John Wiley & Sons Ltd on behalf of Pathological Society of Great Britain and Ireland.
Causal inference for evaluating prescription opioid abuse using trend‐in‐trend design
Authors: Dasgupta Nabarun , Schwarz John , Hennessy Sean , Ertefaie Askhan , Dart Richard C.
Published: February 2019

Purpose

One response to the opioid crisis in the United States has been the development of opioid analgesics with properties intended to reduce non‐oral use. Previous evaluations of abuse in the community have relied on population averaged interrupted time series Poisson models with utilization offsets. However, competing interventions and secular trends complicate interpretation of time‐series analyses. An alternative research design, trend‐in‐trend, accounts for heterogeneity in per capita opioid dispensing and unmeasured time‐varying confounding, which provides a causal evaluation, provided that underlying assumptions are met.

Methods

Trend‐in‐trend can be modeled using a logistic regression framework. In logistic regression, exposure was any product‐specific outpatient dispensing by three‐digit ZIP code and calendar quarter, for 22 opioids. The outcome was any product‐specific abuse case ascertained from poison centers and drug treatment programs, covering 94% of the US population, between July 2009 and December 2016. Product‐specific odds ratios compared places without dispensing with places with any dispensing; the causal contrast represents the odds of product‐specific abuse in the community given exposure.

Results

Dispensing of new and low‐volume opioids varied considerably across the country, with no region showing high of all products. Of 22 opioids analyzed, the three with approved labeling as intended to deter abuse ranked near the lowest in both absolute (population‐adjusted rates: 1.7, 0.9, and 8.2 per million people per quarter, respectively) and relative measures (trend‐in‐trend ORs: 1.96, 1.79, 1.69, respectively).

Conclusions

Postmarketing studies of prescription opioid abuse may benefit by evolving from unadjusted surveillance rates to a causal inference approach.
A Refined One‐Slit‐Ring Method to Quantify Residual Hoop Stress in Chlorinated Polyvinyl Chloride Pipe—Application to Specimens After Immersion in Primer
Authors: Chen Bingjun , Jar P.‐Y. Ben , Mertiny Pierre , Prybysh Robert
Published: February 2019

A refined one‐slit‐ring method is presented to characterize residual hoop stress distribution in pipe ring specimens of inhomogeneous cross section. Although the original one‐slit‐ring method enables determination of residual hoop stress distribution through slitting single ring specimen in the axial direction, its use is limited to specimens of uniform material properties. This work is to extend applicability of the method to ring specimens with a cross section of core–shell structure. Chlorinated polyvinyl chloride (CPVC) pipe is used in the study, and core–shell structure in its ring specimens is introduced through immersion in primer for 30 min. Analytical expression for the residual hoop stress distribution in these specimens is derived, and verified using finite element (FE) simulation which uses a temperature gradient field to generate stress so that diametrical change by the slitting is same as that measured experimentally. Results from the analytical expression agree well with those from the FE simulation, showing decrease of the residual hoop stress by the exposure to primer, and the extent of decrease depends on the drying time after the immersion in primer, to about half of its original value after 30 days of drying, and then remains relatively constant afterwards. POLYM. ENG. SCI., 59:E296–E309, 2019. © 2019 Society of Plastics Engineers
Size‐Dependence of the Melting Temperature of Individual Au Nanoparticles
Authors: Schlexer Philomena , Andersen Anton Bay , Sebok Bela , Chorkendorff Ib , Schiøtz Jakob , Hansen Thomas W.
Published: February 2019

Nanoparticles have an immense importance in various fields, such as medicine, catalysis, and various technological applications. Nanoparticles exhibit a significant depression in melting point as their size goes below ≈10 nm. However, nanoparticles are frequently used in high temperature applications such as catalysis where temperatures often exceed several 100 degrees which makes it interesting to study not only the melting temperature depression, but also how the melting progresses through the particle. Using high‐resolution transmission electron microscopy, the melting process of gold nanoparticles in the size range of 2–20 nm Au nanoparticles combined with molecular dynamics studies is investigated. A linear dependence of the melting temperature on the inverse particle size is confirmed; electron microscopy imaging reveals that the particles start melting at the surface and the liquid shell formed then rapidly expands to the particle core.
Scalable remote homology detection and fold recognition in massive protein networks
Authors: Petegrosso Raphael , Li Zhuliu , Srour Molly A. , Saad Yousef , Zhang Wei , Kuang Rui
Published: February 2019

The global connectivities in very large protein similarity networks contain traces of evolution among the proteins for detecting protein remote evolutionary relations or structural similarities. To investigate how well a protein network captures the evolutionary information, a key limitation is the intensive computation of pairwise sequence similarities needed to construct very large protein networks. In this article, we introduce label propagation on low‐rank kernel approximation (LP‐LOKA) for searching massively large protein networks. LP‐LOKA propagates initial protein similarities in a low‐rank graph by Nyström approximation without computing all pairwise similarities. With scalable parallel implementations based on distributed‐memory using message‐passing interface and Apache‐Hadoop/Spark on cloud, LP‐LOKA can search protein networks with one million proteins or more. In the experiments on Swiss‐Prot/ADDA/CASP data, LP‐LOKA significantly improved protein ranking over the widely used HMM‐HMM or profile‐sequence alignment methods utilizing large protein networks. It was observed that the larger the protein similarity network, the better the performance, especially on relatively small protein superfamilies and folds. The results suggest that computing massively large protein network is necessary to meet the growing need of annotating proteins from newly sequenced species and LP‐LOKA is both scalable and accurate for searching massively large protein networks.
Mammalian antimicrobial peptide protegrin‐4 self assembles and forms amyloid‐like aggregates: Assessment of its functional relevance
Authors: Gour Shalini , Kumar Vijay , Singh Ashutosh , Gadhave Kundlik , Goyal Pankaj , Pandey Janmejay , Giri Rajanish , Yadav Jay Kant
Published: February 2019

Protegrin‐4 (PG‐4) is a member of the porcine leukocyte protegrins family of cysteine‐rich antimicrobial peptides (AMPs) isolated from Sus scrofa. It consists of 18 amino acid residues and works as a part of innate immune system. In this study, we examined the intrinsic aggregation propensity of this AMP using multiple computational algorithms, namely, TANGO, AGGRESCAN, FOLDAMYLOID, AMYLPRED, and ZYGGREGATOR, and found that the peptide is predicted to have a high propensity for the β sheet formation that disposes this peptide to be amyloidogenic. Under in vitro conditions, PG‐4 formed visible aggregates and displayed the hallmark properties of typical amyloids such as enhanced binding of Congo red, increased fluorescence with Thioflavin‐T, and fibrillar morphology under transmission electron microscopy. Then we examined its antimicrobial activity against Bacillus subtilis and found that the aggregated peptide retained its antimicrobial activity. Additionally, the aggregates remain non‐toxic to the HEK293 and Caco2 cells. Our study suggests that the inherent aggregation properties of AMP can rationally be explored as a potential source of peptide‐based antimicrobials with enhanced stability.
Comparison of 4DVAR and EnKF state estimates and forecasts in the Gulf of Mexico
Authors: Gopalakrishnan Ganesh , Hoteit Ibrahim , Cornuelle Bruce D. , Rudnick Daniel L.
Published: February 2019

An experiment is conducted to compare four‐dimensional variational (4DVAR) and ensemble Kalman filter (EnKF) assimilation systems and their predictability in the Gulf of Mexico (GoM) using the Massachusetts Institute of Technology general circulation model (MITgcm). The quality of the ocean‐state estimates, forecasts, and the contribution of ensemble prediction are evaluated. The MITgcm–Estimating the Circulation and Climate of the Ocean (ECCO) 4DVAR (MITgcm–ECCO) and the MITgcm–Data Assimilation Research Testbed (DART) EnKF (MITgcm–DART) systems were used to compute two‐month hindcasts (March–April, 2010) by assimilating satellite‐derived along‐track sea‐surface height (SSH) and gridded sea‐surface temperature (SST) observations. The estimates from both methods at the end of the hindcast period were then used to initialize forecasts for two months (May–June, 2010). This period was selected because a loop current (LC) eddy (Eddy Franklin: Eddy‐F) detachment event occurred at the end of May 2010, immediately after the Deepwater Horizon (DwH) oil spill. Despite some differences between the setups, both systems produce analyses and forecasts of comparable quality and both solutions significantly outperformed model persistence. A reference forecast initialized from the 1/12° Hybrid Coordinate Ocean Model (HYCOM)/NCODA global analysis also performed well. The EnKF experiments for sensitivity to filter parameters showed enhanced predictability when using more ensemble members and stronger covariance localization, but not for larger inflation. The EnKF experiments varying the number of assimilation cycles showed enhanced short‐term (long‐term) predictability with fewer (more) assimilation cycles. Additional hindcast and forecast experiments at other times of significant LC evolution showed mixed performance of both systems, which depends strongly on the background state of the GoM circulation. The present work demonstrates a practical application of both assimilation methods for the GoM and compares them in a limited number of realizations. The overall conclusion showing improved short‐term (long‐term) predictability for EnKF (4DVAR) carries an important caveat that the results from this study are specific to a few 4DVAR and EnKF LC eddy separation experiments in the GoM and cannot be generalized to conclude the relative performance of both methods, especially in other applications. However, some of the concepts and methods should carry over to other applications.
Molecular hydrogen‐induced nucleation of hydrogenated silicon nanocrystals at low temperature
Authors: Filali Larbi , Brahmi Yamina , Sib Jamal Dine , Kail Fatiha , Bouizem Yahya , Benlakehal Djamel , Zellama Kacem , Bouhekka Ahmed , Kebab Aissa , Chahed Larbi
Published: February 2019

Highly crystallized hydrogenated silicon layers were obtained via the treatment of hydrogenated polymorphous silicon films in a molecular hydrogen ambient. This contrasts other postdeposition studies that obtained nanocrystalline silicon films but necessitated either a plasma activation or high‐temperature annealing. The structure of the samples was analyzed by Raman spectroscopy to determine the crystallite volume fraction, which was found to increase up to 80% within 1 hour of treatment. Atomic force microscopy (AFM) showed that the roughness of the surfaces was found to increase after the H2 treatment. Optical transmission and spectroscopic ellipsometry revealed the pronounced porosity of the films characterized by a static refractive index that is below three, which is a low value for hydrogenated silicon films and a void fraction that is around 15% in the bulk of the films. The effect of the hydrogen molecules on the structure of the films was discussed in terms of the compressive stress exerted by the molecules, trapped in structural inhomogeneities, on the amorphous tissue. It is suggested that for this process to take effect, the films need to be porous and that the amorphous network needs to be in a “relaxed” state.
Multilevel Microstructured Flexible Pressure Sensors with Ultrahigh Sensitivity and Ultrawide Pressure Range for Versatile Electronic Skins
Authors: Tang Xing , Wu Congyi , Gan Lin , Zhang Tian , Zhou Tingting , Huang Jin , Wang Hao , Xie Changsheng , Zeng Dawen
Published: February 2019

Flexible pressure sensors as electronic skins have attracted wide attention to their potential applications for healthcare and intelligent robotics. However, the tradeoff between their sensitivity and pressure range restricts their practical applications in various healthcare fields. Herein, a cost‐effective flexible pressure sensor with an ultrahigh sensitivity over an ultrawide pressure‐range is developed by combining a sandpaper‐molded multilevel microstructured polydimethylsiloxane and a reduced oxide graphene film. The unique multilevel microstructure via a two‐step sandpaper‐molding method leads to an ultrahigh sensitivity (2.5–1051 kPa−1) and can detect subtle and large pressure over an ultrawide range (0.01–400 kPa), which covers the overall pressure regime in daily life. Sharp increases in the contact area and additional contact sites caused by the multilevel microstructures jointly contribute to such unprecedented performance, which is confirmed by in situ observation of the gap variations and the contact states of the sensor under different pressures. Examples of the flexible pressure sensors are shown in potential applications involving the detection of various human physiological signals, such as breathing rate, vocal‐cord vibration, heart rate, wrist pulse, and foot plantar pressure. Another object manipulation application is also demonstrated, where the material shows its great potential as electronic skin intelligent robotics and prosthetic limbs.
Graphene‐Encapsulated FeS2 in Carbon Fibers as High Reversible Anodes for Na+/K+ Batteries in a Wide Temperature Range
Authors: Chen Changmiao , Yang Yincai , Tang Xuan , Qiu Renhua , Wang Shuangyin , Cao Guozhong , Zhang Ming
Published: February 2019

Developing low cost, long life, and high capacity rechargeable batteries is a critical factor towards developing next‐generation energy storage devices for practical applications. Therefore, a simple method to prepare graphene‐coated FeS2 embedded in carbon nanofibers is employed; the double protection from graphene coating and carbon fibers ensures high reversibility of FeS2 during sodiation/desodiation and improved conductivity, resulting in high rate capacity and long‐term life for Na+ (305.5 mAh g−1 at 3 A g−1 after 2450 cycles) and K+ (120 mAh g−1 at 1 A g−1 after 680 cycles) storage at room temperature. Benefitting from the enhanced conductivity and protection on graphene‐encapsulated FeS2 nanoparticles, the composites exhibit excellent electrochemical performance under low temperature (0 and −20 °C), and temperature tolerance with stable capacity as sodium‐ion half‐cells. The Na‐ion full‐cells based on the above composites and Na3V2(PO4)3 can afford reversible capacity of 95 mAh g−1 at room temperature. Furthermore, the full‐cells deliver promising discharge capacity (50 mAh g−1 at 0 °C, 43 mAh g−1 at −20 °C) and high energy density at low temperatures. Density functional theory calculations imply that graphene coating can effectively decrease the Na+ diffusion barrier between FeS2 and graphene heterointerface and promote the reversibility of Na+ storage in FeS2, resulting in advanced Na+ storage properties.
Prospects for a measurement of the W boson mass in the all-jets final state at hadron colliders
Authors: Freytsis Marat , Harris Philip , Hinzmann Andreas , Moult Ian , Tran Nhan , Vernieri Caterina
Published: February 2019

Abstract

Precise measurements of the mass of theWboson are important to test the overall consistency of the Standard Model of particle physics. The current best measurements of theWboson mass come from single production measurements at hadron colliders in its decay mode to a lepton (electron or muon) and a neutrino and pair production ofWbosons at lepton colliders, where both the leptonic and hadronic decay modes of theWboson have been considered. In this study, prospects for a measurement of theWboson mass in the all-jet final state at hadron colliders are presented. The feasibility of this measurement takes advantage of numerous recent developments in the field of jet substructure. Compared to other methods for measuring theWmass, a measurement in the all-jets final state would be complementary in methodology and have systematic uncertainties orthogonal to previous measurements. We have estimated the main experimental and theoretical uncertainties affecting a measurement in the all-jet final state. With new trigger strategies, a statistical uncertainty for the measurement of the mass difference between theZandWbosons of 30 MeV could be reached with HL-LHC data corresponding to 3000 fb−1of integrated luminosity. However, in order to reach that precision, the current understanding of non-perturbative contributions to the invariant mass ofW→$$ q\overline{q}^{\prime } $$qq¯′andZ→$$ b\overline{b} $$bb¯jets will need to be refined. Similar strategies will also allow the reach for generic boosted resonances searches in hadronic channels to be extended.
Pathology Evaluation of Reduction Mammaplasty Specimens and Subsequent Diagnosis of Malignant Breast Disease: A Claims‐Based Analysis
Authors: Sears Erika D. , Lu Yu‐Ting , Chung Ting‐Ting , Momoh Adeyiza O. , Chung Kevin C.
Published: February 2019

Background

This study aimed to measure the use of pathology evaluation of breast specimens among patients undergoing reduction mammaplasty and assess rates of new diagnoses of breast disease and associated cost.

Methods

We analyzed the Truven MarketScan Databases from 2009 to 2015 to identify adult female patients undergoing reduction mammaplasty for macromastia. We recorded patient age, rates of obtaining pathology evaluation, new diagnoses of benign or malignant breast disease after pathology evaluation, and total cost for the surgery encounter.

Results

Among 17,738 macromastia patients undergoing reduction mammaplasty, 91.3% (n = 16,193) received pathology evaluation. Pathology evaluation rates were clinically similar across age groups <70 years (90.8–92.1%) and slightly lower for patients ≥70 (85.0%). Among 6987 patients less than 40 years who received pathology evaluation, 0.06% (n = 4) were subsequently diagnosed with malignant breast disease within 3 months, compared to 0.23% in the entire cohort (n = 37/16,193). Pathology claims resulted in an added $307 (SD 251) on average for the breast reduction surgery encounters.

Conclusions

Breast tissue after reduction mammaplasty is routinely submitted for pathology evaluation, without consideration of age‐based risk for breast cancer. Routine pathology evaluation of breast tissue in patients in lower risk age groups (less than 40 years) required an additional $536,000 on average to detect a single occult breast cancer compared to an added $85,600 to detect a new malignancy in patients 40 years and older. Clinicians and policy makers should consider whether routine pathology evaluation of breast tissue should be individualized based on risk factors for breast cancer.
Regulating the Golgi apparatus sorting of proteinase A to decrease its excretion in Saccharomyces cerevisiae
Authors: Song Lulu , Chen Yefu , Guo Qinghuan , Huang Siyao , Guo Xuewu , Xiao Dongguang
Published: February 2019

Beer foam stability, a key factor in evaluating overall beer quality, is influenced by proteinase A (PrA). Actin-severing protein cofilin and Golgi apparatus-localized Ca2+ ATPase Pmr1 are involved in protein sorting at the trans-Golgi network (TGN) in yeast Curwin et al. (Mol Biol Cell 23:2327–2338, 2012). To reduce PrA excretion into the beer fermentation broth, we regulated the Golgi apparatus sorting of PrA, thereby facilitating the delivery of more PrA to the vacuoles in the yeast cells. In the present study, the cofilin-coding gene COF1 and the Pmr1-coding gene PMR1 were overexpressed in the parental strain W303-1A and designated as W + COF1 and W + PMR1, respectively. The relative expression levels of COF1 in W + COF1 and PMR1 in W + PMR1 were 5.26- and 19.76-fold higher than those in the parental strain. After increases in the expression levels of cofilin and Pmr1 were confirmed, the PrA activities in the wort broth fermented with W + COF1, W + PMR1, and W303-1A were measured. Results showed that the extracellular PrA activities of W + COF1 and W + PMR1 were decreased by 9.24% and 13.83%, respectively, at the end of the main fermentation compared with that of W303-1A. Meanwhile, no apparent differences were found on the fermentation performance of recombinant and parental strains. The research uncovers an effective strategy for decreasing PrA excretion in Saccharomyces cerevisiae.
The United States-Mexico-Canada Agreement: A Glimpse into The Geoeconomic World Order
Authors: Puig Sergio
Published: February 2019

The United States-Mexico-Canada Agreement (USMCA) differs in a few important ways from prior trade deals signed by the United States but reveals a glimpse of the infrastructure for a new era in international economic governance. This new “Geoeconomic World Order,” will be characterized by great power rivalry between the United States and China, the intense use of protectionist tools to achieve strategic and political goals, and the diminished role of legal adjudication. This approach to trade policy will likely outlast the autocratic and/or nationalistic governments emerging around the world, including the current Trump administration. While international trade law will recover, it will look different in key respects—it will be less multilateral, predictable, justiciable, and enforceable. This more transactional view of international trade law implies a limit on the role of law and an increase in the use of power. It may force a retrenchment of international interdependence and a revival of zones of influence prevalent during the Cold War era.
Restricted nonlinear model for high- and low-drag events in plane channel flow
Authors: Alizard Frédéric , Biau Damien
Published: February 2019

A restricted nonlinear (RNL) model, obtained by partitioning the state variables into streamwise-averaged quantities and superimposed perturbations, is used in order to track the exact coherent state in plane channel flow investigated by Toh & Itano (J. Fluid Mech., vol. 481, 2003, pp. 67–76). When restricting nonlinearities to quadratic interaction of the fluctuating part into the streamwise-averaged component, it is shown that the coherent structure and its dynamics closely match results from direct numerical simulation (DNS), even if only a single streamwise Fourier mode is retained. In particular, both solutions exhibit long quiescent phases, spanwise shifts and bursting events. It is also shown that the dynamical trajectory passes close to equilibria that exhibit either low- or high-drag states. When statistics are collected at times where the friction velocity peaks, the mean flow and root-mean-square profiles show the essential features of wall turbulence obtained by DNS for the same friction Reynolds number. For low-drag events, the mean flow profiles are related to a universal asymptotic state called maximum drag reduction (Xi & Graham, Phys. Rev. Lett., vol. 108, 2012, 028301). Hence, the intermittent nature of self-sustaining processes in the buffer layer is contained in the dynamics of the RNL model, organized in two exact coherent states plus an asymptotic turbulent-like attractor. We also address how closely turbulent dynamics approaches these equilibria by exploiting a DNS database associated with a larger domain.
Sámi language teachers’ professional identities explained through narratives about language acquisition
Authors: Hammine Madoka , Keskitalo Pigga , Katjaana Sarivaara Erika
Published: February 2019

AbstractConducted in northern Finland, this study examines Sámi language teachers’ professional identities through their narratives of language acquisition. We focus on how teachers’ professional identities are shaped by their language acquisition process. The results are based on the narratives of nine North, Inari and Skolt Sámi language teachers. Two aspects of teachers’ narratives were significantly linked to their identities as Sámi language teachers: (1) their backgrounds (indigenous/non-indigenous) and (2) their language acquisition experiences (acquired Sámi language in childhood/adulthood). Indigenous teachers appeared to express their professional identities strongly despite their challenging acquisition experiences and were inclined to work towards the future of Sámi languages. In addition, non-indigenous teachers were willing to further the development of Sámi languages although they are not indigenous, which perhaps contributes towards the future of Sámi languages. Teachers narrated complex thoughts about language acquisition and their professional identity and helped develop indigenous language education in their respective indigenous communities. We recommend that teachers’ in pre-service and service education should prepare and support indigenous language teachers by sharing knowledge about multilingual education practices and coping skills, particularly to help the latter manage varied tasks and heterogeneous contexts. Thus, this research study shows that both teachers’ language acquisition experiences and their current work situations shape their professional identity.
Bryozoan fauna from the Reynales Formation (lower Silurian, Aeronian) of New York, USA
Authors: Ernst Andrej , Brett Carlton E. , Wilson Mark A.
Published: February 2019

Thirteen bryozoan species are described from the Brewer Dock (Hickory Corners) Member of the Reynales Formation (lower Silurian, Aeronian) at the locality Hickory Corners in western New York, USA. Three species are new: trepostomesHomotrypa niagarensisn. sp. andLeioclema adsuetumn. sp. and the rhabdomesine cryptostomeMoyerella parvan. sp. Only one species,Hennigopora aptaPerry and Hattin, 1960, developed obligatory encrusting colonies whereas the others produced erect ramose colonies of various thicknesses and shapes: cylindrical, branched, and lenticular. Bryozoans display high abundance and richness within the rock. This fauna is characteristic of a moderately agitated environment with a stable substrate. The identified species reveal paleobiogeographic connections to other Silurian localities of New York as well as Ohio and Indiana (USA) and Anticosti (Canada).

UUID:http://zoobank.org/c24f3184-4a8e-44c4-b6c0-d30433e841c9
Remarkable preservation of shell microstructures from the Late Ordovician of the Cincinnati Arch region, USA, and the success of nacre among Ordovician mollusks
Authors: Vendrasco Michael J. , Checa Antonio G. , Heimbrock William P.
Published: February 2019

Exceptional sub-micrometer details of shell microstructure are preserved in phosphatic micro-steinkerns representing several phyla from shell beds of the Upper Ordovician of the Cincinnati Arch region, USA. These fossils provide the most detailed record of Ordovician mollusk shell microstructures, as well as exceptional details on the earliest cases of undisputed nacre. The trend towards nacre in the Mollusca is one aspect of the surge in escalation between mollusks and their predators during the Great Ordovician Biodiversification Event.
The Origins of Ethnic Activism: Caste Politics in Colonial India
Authors: Lee Alexander
Published: February 2019

Existing accounts of ethnic mobilization have focused on the role of group size or state policy. This paper suggests that narrow identity activism was also non-linearly related to education since poorly-educated groups are unlikely to have an educated elite to participate in activism, while in very educated groups this elite existed but participated in the colonial state or anti-colonial nationalism. This theory is tested using a historical panel dataset of Indian caste groups, with petitions to the colonial census authorities being used as an index of caste activism.
Culture, Politics and the Cold War: The Sociedad de Escritores de Chile in the 1950s
Authors: Nállim Jorge A.
Published: February 2019

In the 1950s, the Sociedad de Escritores de Chile experienced bitter disputes caused by the efforts of the Chilean Committee for Cultural Freedom, the local branch of a major institution in the US cultural Cold War, to gain control of the association. These disputes reveal the role played by the cultural Cold War in the breakdown of older political and intellectual alliances in Chile. They also highlight the transnational networks that connected Chilean writers during the Cold War, and the complex articulation of local and international contexts and agendas that influenced Chilean cultural and political groups.
‘Sovereign Parenting’ in Affluent Latin American Neighbourhoods: Race and the Politics of Childcare in Ipanema (Brazil) and El Condado (Puerto Rico)
Authors: Ramos-Zayas Ana Y.
Published: February 2019

Drawing on ethnographic research conducted among parents living in the affluent neighbourhoods of Ipanema, Brazil, and El Condado, Puerto Rico, I examine how urban Latin American elites deployed their parenting practices as moral justification for their racial and class privilege (what I call ‘sovereign parenting’). One way in which they do this is by producing particular forms of affective relationships with their nannies. The women these upper-class parents hired were largely dark-skinned immigrants: from the Dominican Republic, to work in El Condado, and from the Brazilian Northeast, to work in Ipanema. I demonstrate how elites cultivated a form of ‘informality’ and expressions of care in relation to childcare workers in ways that not only produced whiteness as a pillar of Latin American liberalism, but also associated whiteness with the world of interiority and personal growth.
Is coding a relevant metaphor for the brain?
Authors: Brette Romain
Published: February 2019

“Neural coding” is a popular metaphor in neuroscience, where objective properties of the world are communicated to the brain in the form of spikes. Here I argue that this metaphor is often inappropriate and misleading. First, when neurons are said to encode experimental parameters, the neural code depends on experimental details that are not carried by the coding variable (e.g., the spike count). Thus, the representational power of neural codes is much more limited than generally implied. Second, neural codes carry information only by reference to things with known meaning. In contrast, perceptual systems must build information from relations between sensory signals and actions, forming an internal model. Neural codes are inadequate for this purpose because they are unstructured and therefore unable to represent relations. Third, coding variables are observables tied to the temporality of experiments, whereas spikes are timed actions that mediate coupling in a distributed dynamical system. The coding metaphor tries to fit the dynamic, circular, and distributed causal structure of the brain into a linear chain of transformations between observables, but the two causal structures are incongruent. I conclude that the neural coding metaphor cannot provide a valid basis for theories of brain function, because it is incompatible with both the causal structure of the brain and the representational requirements of cognition.
Dexterous Remote Manipulation by Means of a Teleoperation System
Authors: Pliego-Jiménez Javier , Arteaga-Pérez Marco A. , Cruz-Hernández César
Published: February 2019

Humans are experts in manipulation and grasping tasks. However, several industrial tasks represent a risk to human operators, for instance, handling radioactive material or transporting heavy objects. Teleoperation robotic schemes extend human capabilities, but they are highly nonlinear systems. In this paper, we address the problem of dexterous remote manipulation by means of a unilateral heterogenous teleoperation scheme composed by a single-master and multiple-slave manipulators handling a rigid object. In order to achieve a stable grasp, a decentralized force/position controller with continuous and bounded input torques based on the Orthogonalization Principle and a second-order sliding mode control is proposed for the slave robots. In addition, a trajectory planning method based on holonomic constraints is proposed to control multiple-slave manipulators with a single-master device. Experimental results are presented to evaluate the performance of the proposed approach.
Selecting digital health technologies for validation and piloting by healthcare providers: a decision-making perspective from ontario
Authors: Chahal Amarjit , Rudnick Abraham
Published: February 2019

Digital health technologies (DHTs) such as health apps are rapidly emerging as a major disruptor of health care. Yet there is no well-established process of decision making for selecting DHTs that are worthy of investing resources in their validation to determine whether they are ready (safe, effective, and not too costly) for health related use. We report here on an Ontario-based initiative to support such decision making. Specifically, we developed a decision-making algorithm that uses approved criteria including the strategic direction of the health research institute and the hospital, and availability of resources. The Council of Academic Hospitals of Ontario has adapted our approach for other hospitals. We hope that other healthcare organizations, in and beyond Ontario, will consider this and alternative approaches, and that research will be conducted to evaluate such approaches.
Anomalous origin of left vertebral artery from ascending aorta associated with interrupted aortic arch and persistent truncus arteriosus
Authors: Pandey Niraj N. , Sharma Arun , Kumar Sanjeev
Published: February 2019

We present a case of a 3-week-old boy with persistent truncus arteriosus associated with interrupted right aortic arch having an anomalous origin of the left vertebral artery from the ascending aorta.
Successful everolimus-eluting stent implantation into the left main trunk stenosis in the anomalous coronary artery after neo-aortic valve replacement in a 6-year-old boy
Authors: Asada Dai , Tomita Hideshi , Fujii Takanari
Published: February 2019

CHDs occasionally have coronary complications; however, stent implantation is technically difficult in small children. We reported a successful drug-eluting stent implantation into the congenital anomalous coronary artery in a 6-year-old boy. This treatment is useful for rescuing coronary stenosis, and dual antiplatelet therapy is important to prevent stent restenosis.
Aggressiveness and violence in psychiatric patients: a clinical or social paradigm?
Authors: Mauri Massimo C. , Cirnigliaro Giovanna , Di Pace Chiara , Paletta Silvia , Reggiori Alessandra , Altamura Carlo A. , Dell’Osso Bernardo
Published: February 2019

Objective

Psychiatric disorders are often considered the leading cause of violence. This may be due to a stereotype created by media and general opinion.

Method

The Modified Overt Aggression Scale (MOAS) was used to evaluate the severity of aggressive and violent behaviors in 400 patients who attended a post-acute psychiatric service in Milan from 2014 to 2016 and suffered from different psychiatric disorders. The psychopathological clinical picture was evaluated by Clinical Global Impression (CGI). The study also assessed the possible correlation between epidemiologic and sociodemographic factors, clinical variables, and aggression and violence.

Results

Of the total number of subjects, 21.50% showed a MOAS score >0, 11.50% presented mild aggression (0–10 MOAS weighted score), 9% moderate aggression (11–20), and 1% severe aggression (MOAS >20). With respect to violent behaviors, 16% of patients showed a score >0 in one MOAS subscale other than verbal aggression according to violence definition. The severity of clinical picture seemed to be related to higher weighted MOAS score. Multivariate testing of different sociodemographic and clinical variables showed that violence was related to unemployment status, and significantly correlated to compulsory admission (TSO), suicide attempts (TS), and personality disorders, while the severity of clinical psychiatric picture seemed to play a secondary role.

Conclusion

Results have shown that personality disorders and sociodemographic factors, including economic factors, seem to be major determinants of violence among patients diagnosed with mental disorders.
Calibration of Atom Probe Tomography Reconstructions Through Correlation with Electron Micrographs
Authors: Mouton Isabelle , Katnagallu Shyam , Makineni Surendra Kumar , Cojocaru-Mirédin Oana , Schwarz Torsten , Stephenson Leigh Thomas , Raabe Dierk , Gault Baptiste
Published: February 2019

Although atom probe tomography (APT) reconstructions do not directly influence the local elemental analysis, any structural inferences from APT volumes demand a reliable reconstruction of the point cloud. Accurate estimation of the reconstruction parameters is crucial to obtain reliable spatial scaling. In the current work, a new automated approach of calibrating atom probe reconstructions is developed using only one correlative projection electron microscopy (EM) image. We employed an algorithm that implements a 2D cross-correlation of microstructural features observed in both the APT reconstructions and the corresponding EM image. We apply this protocol to calibrate reconstructions in a Cu(In,Ga)Se2-based semiconductor and in a Co-based superalloy. This work enables us to couple chemical precision to structural information with relative ease.
Charge-State Field Evaporation Behavior in Cu(V) Nanocrystalline Alloys
Authors: Zhou Xuyang , Thompson Gregory B.
Published: February 2019

Atom probe tomography (APT) of a nanocrystalline Cu–7 at.% V thin film annealed at 400°C for 1 h revealed chemical partitioning in the form of solute segregation. The vanadium precipitated along high angle grain boundaries and at triple junctions, determined by cross-correlative precession electron diffraction of the APT specimen. Upon field evaporation, the V2+/(V1+ + VH1+) ratio from the decomposed ions was ~3 within the matrix grains and ~16 within the vanadium precipitates. It was found that the VH1+ complex was prevalent in the matrix, with its presence explained in terms of hydrogen's ability to assist in field evaporation. The change in the V2+/(V1+ + VH1+) charge-state ratio (CSR) was studied as a function of base temperature (25–90 K), laser pulse energy (50–200 pJ), and grain orientation. The strongest influence on changing the CSR was with the varied pulse laser, which made the CSR between the precipitates and the matrix equivalent at the higher laser pulse energies. However, at these conditions, the precipitates began to coarsen. The collective results of the CSRs are discussed in terms of field strengths related to the chemical coordination.
What are social work students being taught about palliative care?
Authors: Stein Gary L. , Berkman Cathy , Pollak Bonnie
Published: February 2019

Objective

Palliative social workers have taken steps to increase the numbers of social workers trained and competent to deliver effective psychosocial palliative care. Despite these developments, masters of social work (MSW) programs have only begun to develop curricula preparing students for entry-level practice. This study sought to determine the type and extent of content areas included in MSW courses dedicated to palliative care or with content related to palliative care practice.

Method

A cross-sectional study using an online questionnaire was conducted. All 248 accredited MSW programs in the United States and 32 programs in Canada were invited to participate. Participants were asked to name the courses in their MSW program that were dedicated to, or included content on, palliative care, and submit the syllabi for these courses. Data comprised course content for each class session and required readings. A grounded theory approach was used to identify the topics covered.

Result

Of the 105 participating programs that responded to the survey, 42 submitted 70 syllabi for courses with at least some palliative care content. There were 29 topics identified. The most common topic was grief, loss, and bereavement, followed closely by behavioral and mental health issues, and supporting family and friends; cultural perspectives and advance care planning were also common topics. For the 10 syllabi from courses dedicated to palliative care, supporting family was the most common topical area, followed closely by interprofessional practice and advance care planning.

Significance of results

Although there are many challenges to introducing palliative care content into MSW programs, including unqualified faculty and competing course material and electives of equally compelling content, there are model curricula for dedicated palliative care courses. With the large growth of palliative care programs, the time is ripe to add specialty palliative care courses and to add palliative care content into existing courses.
Lifetime experience of multiple common mental disorders and 19-year mortality: results from a Canadian population-based cohort
Authors: Kingsbury M. , Sucha E. , Horton N. J. , Sampasa-Kanyinga H. , Murphy J. M. , Gilman S. E. , Colman I.
Published: February 2019

Aims

To examine the impact of multiple psychiatric disorders over the lifetime on risk of mortality in the general population.

Methods

Data came from a random community-based sample of 1397 adults in Atlantic Canada, recruited in 1992. Major depression, dysthymia, panic disorder, generalised anxiety disorder and alcohol use disorders were assessed using the Diagnostic Interview Schedule (DIS). Vital status of participants through 2011 was determined using probabilistic linkages to the Canadian Mortality Database. Cox proportional hazard models with age at study entry as the time scale were used to investigate the relationship between DIS diagnoses and mortality, adjusted for participant education, smoking and obesity at baseline.

Results

Results suggested that mood and anxiety disorders rarely presented in isolation – the majority of participants experienced multiple psychiatric disorders over the lifetime. Elevated risk of death was found among men with both major depression and dysthymia (HR 2.56; 95% CI 1.12–5.89), depression and alcohol use disorders (HR 2.45; 95% CI 1.18–5.10) and among men and women who experienced both panic disorder and alcohol use disorders (HR 3.80; 95% CI 1.19–12.16).

Conclusion

The experience of multiple mental disorders over the lifetime is extremely common, and associated with increased risk of mortality, most notably among men. Clinicians should be aware of the importance of considering contemporaneous symptoms of multiple psychiatric conditions.
Magma Propagation at Piton de la Fournaise From Joint Inversion of InSAR and GNSS
Authors: Smittarello D. , Cayol V. , Pinel V. , Peltier A. , Froger J‐L. , Ferrazzini V.
Published: February 2019

Magma propagation is an unsteady process controlled by magma‐crust interaction. To provide information on its dynamics, we invert complementary ground deformation data spanning the 8 hr preceding the 26 May 2016 eruption at Piton de la Fournaise (PdF) volcano (La Réunion, France). Data are inverted using 3‐D boundary element models combined with a Monte Carlo inversion method. The final geometry of the displacement source is determined based on four interferograms spanning the whole propagation phase while the dynamics of the propagation is inferred from temporal inversion of continuous Global Navigation Satellite System (GNSS) data, using the final geometry as an a priori to constrain the source. The best modeled magma path consists in a 2,700‐m‐long sill located 800 m above sea level and connected to the eruptive fissure by a subvertical dike. The quick opening of the horizontal part of the intrusion could have been favored by limited flank sliding during the early stage of propagation. The intrusion then stalled for ∼5 hr, while pressure increased slightly, until final upward propagation and eruption. Volume budget suggests that the eruption was fed by a single batch of magma quickly disconnected from its source. The delay prior to the eruption may reflect a limited magma supply. Finally, two mechanisms, potentially acting together, might have favored the eruption: a driving role of magmatic gas and/or, as often observed at Piton de la Fournaise, an eastward flank slip.
Correction: Riluzole reduces amyloid beta pathology, improves memory, and restores gene expression changes in a transgenic mouse model of early-onset Alzheimer’s disease
Authors: Okamato Masahiro , Gray Jason D. , Larson Chloe S. , Kazim Syed Faraz , Soya Hideaki , McEwen Bruce S. , Pereira Ana C.
Published: February 2019

The author’s name was spelled incorrectly as “Masahir Okamoto”. This has been updated to “Masahiro Okamoto” in the HTML and PDF of the article.