bluuebunny/crossref_metadata_2025 huggingface dataset:
Sediment Budget and Net Sediment Transport on a Coast Dominated by Waves and Offshore Currents: A Case Study on the Ishikawa Coast and Its Surrounding Areas in Japan
Authors: Thunyaphun Tussanun , Umeda Shinya , Yuhi Masatoshi
Published: March 2023

This study discusses the coastal sediment budget for the Ishikawa coast using 12 years of observational datasets; it involves an understanding the local and regional sediment dynamics, the intensity of the transport processes in the region, and sediment supply from a local river. Although alongshore sediment transport and sediment budgets have been analyzed in previous studies, only a few conducted cross-shore sediment transport evaluations. The concentration of suspended sediments will be determined in this study, taking into account the influence of waves that are associated with the coastal current. The cross-shore sediment transport using sediment budget analysis indicated that the net alongshore sediment transport directions in the surf and offshore zones are opposite on the Ishikawa coast. The increase in the sediment budget of the surf zone can be attributed to the river sediment supply and longshore sediment transport inflow. Because of the significant outflow components of longshore and cross-shore sediment transports, the offshore zone budget showed a decreasing trend. A detailed sensitivity study was performed by varying the input parameters, in order to determine the possible ranges of net transport rates and sediment transport to the adjacent coasts. The results demonstrated the possibility of a clockwise residual sediment circulation. Our method can be used to analyze the alongshore sediment transport for other coasts and supplement future studies on coastal sedimentology and sediment budgets.
Design Equation of Buckle Propagation Pressure for Pipe-in-Pipe Systems
Authors: Li Ruoxuan , Chen Bai-Qiao , Guedes Soares C.
Published: March 2023

This paper focuses on the buckle propagation pressure of a pipe-in-pipe system under uniform external pressure. After the validation of the finite element model used in this research, several effects were studied. At first, the effects of the initial imperfection of the inner pipe, including the ovality and eccentricity, were checked out. Second, the influence of the scantling of the inner and outer pipes was tested. It was found that the dominant factor which affects the buckle propagation mode is changeable. Then, the boundary value of the above factor was investigated by varying the ratio of the outer and inner diameters. Finally, after a summary of the calculation results, an empirical formula was proposed to illustrate the relationship between the buckle propagation pressure and the geometrical parameters of the pipe-in-pipe system. Utilizing this formula, the buckle propagation pressure of the pipe-in-pipe system can be estimated rapidly with good accuracy.
Ocean Acidification Impedes Foraging Behavior in the Mud Snail Ilyanassa obsoleta
Authors: Manz Maria , Lord Joshua , Morales Melissa
Published: March 2023

Ocean acidification may diminish the response of many marine organisms to chemical cues that can be used to sense nearby food and predators, potentially altering community dynamics. We used a Y-maze choice experiment to investigate the impact of ocean acidification on the ability of mud snails (Ilyanassa obsoleta) to sense food cues in seawater. Mud snails have a well-adapted chemosensory system and play an important role in estuarine ecosystem functioning. Our results showed substantially diminished foraging success for the mud snail under acidified conditions, as snails typically moved towards the food cue in controls (pH 8.1) and away from it in acidified treatments (pH 7.6). These results, coupled with previous work, clearly demonstrate the magnitude at which ocean acidification may impair foraging efficiency, potentially resulting in severe alterations in future ecosystem dynamics.
Exploring the Mycovirus Universe: Identification, Diversity, and Biotechnological Applications
Authors: Villan Larios Diana Carolina , Diaz Reyes Brayan Maudiel , Pirovani Carlos Priminho , Loguercio Leandro Lopes , Santos Vinícius Castro , Góes-Neto Aristóteles , Fonseca Paula Luize Camargos , Aguiar Eric Roberto Guimarães Rocha
Published: March 2023

Viruses that infect fungi are known as mycoviruses and are characterized by the lack of an extracellular phase. In recent years, the advances on nucleic acids sequencing technologies have led to a considerable increase in the number of fungi-infecting viral species described in the literature, with a special interest in assessing potential applications as fungal biocontrol agents. In the present study, we performed a comprehensive review using Scopus, Web of Science, and PubMed databases to mine mycoviruses data to explore their molecular features and their use in biotechnology. Our results showed the existence of 267 mycovirus species, of which 189 are recognized by the International Committee on Taxonomy of Viruses (ICTV). The majority of the mycoviruses identified have a dsRNA genome (38.6%), whereas the Botourmiaviridae (ssRNA+) alone represents 14% of all mycoviruses diversity. Regarding fungal hosts, members from the Sclerotinicaeae appeared as the most common species described to be infected by mycoviruses, with 16 different viral families identified so far. It is noteworthy that such results are directly associated with the high number of studies and strategies used to investigate the presence of viruses in members of the Sclerotinicaeae family. The knowledge about replication strategy and possible impact on fungi biology is available for only a small fraction of the mycoviruses studied, which is the main limitation for considering these elements potential targets for biotechnological applications. Altogether, our investigation allowed us to summarize the general characteristics of mycoviruses and their hosts, the consequences, and the implications of this knowledge on mycovirus–fungi interactions, providing an important source of information for future studies.
Drug-Induced Sleep Endoscopy Findings and Hypoglossal Nerve Stimulation Therapy Outcomes
Authors: Pordzik Johannes , Seifen Christopher , Ludwig Katharina , Hackenberg Berit , Huppertz Tilman , Bahr-Hamm Katharina , Matthias Christoph , Gouveris Haralampos
Published: March 2023

Hypoglossal-nerve stimulation (HGNS) is an established second-line therapy for patients with obstructive sleep apnea (OSA). Existing studies investigating the effect of preoperative drug-induced sleep endoscopic (DISE) findings on HGNS outcomes have mainly focused on the apnea/hypopnea index (AHI) among polysomnography (PSG) parameters, and have less frequently tested other PSG parameters such as the apnea index (AI), hypopnea index (HI), oxygen desaturation index (ODI), snoring index, and arousal index, or patient-reported excessive daytime sleepiness. The aim of this study was to investigate the correlation between DISE findings and the above-mentioned metrics after HGNS therapy. We only included patients with DISE findings providing detailed information about the degree of the anteroposterior velar (APV), oropharyngeal lateral wall (OPLW), or tongue-base (BT) obstruction based on the velum, oropharynx, base of tongue, and epiglottis (VOTE) classification. The data of 25 patients (9 female (36%)) were retrospectively evaluated. The mean age at the date of implantation was 54.52 ± 9.61 years, and the mean BMI was 29.99 ± 3.97 kg/m2. Spearman’s rho correlation coefficients were calculated. Significant correlations were found between the degree of APV obstruction and postoperative HI (r = −0.5, p < 0.05), and between the degree of OPLW obstruction and postoperative snoring index (r = 0.42, p < 0.05). BT obstruction was strongly correlated with postoperative metrics such as AHI (r = −0.57, p < 0.01), AI (r = −0.5, p < 0.05), ODI (r = −0.57, p < 0.01), ∆ AHI (r = 0.58, p < 0.01), ∆ AI (r = 0.54, p < 0.01) and ∆ ODI (r = 0.54, p < 0.01). No significant correlation was found between DISE findings and postoperative Epworth Sleepiness Scale values. These findings suggest that preoperative DISE findings, especially the degree of BT obstruction, are important for predicting an HGNS therapy outcome.
Assessing the Use of Gold as a Zero-Beta Asset in Empirical Asset Pricing: Application to the US Equity Market
Authors: Abdullah Muhammad , Abdou Hussein A. , Godfrey Christopher , Elamer Ahmed A. , Ahmed Yousry
Published: March 2023

This paper examines the use of the return on gold instead of treasury bills in empirical asset pricing models for the US equity market. It builds upon previous research on the safe-haven, hedging, and zero-beta characteristics of gold in developed markets and the close relationship between interest rates, stock, and gold returns. In particular, we extend this research by showing that using gold as a zero-beta asset helps to improve the time-series performance of asset pricing models when pricing US equities and industries between 1981 and 2015. The performance of gold zero-beta models is also compared with traditional empirical factor models using the 1-month Treasury bill rate as the risk-free rate. Our results indicate that using gold as a zero-beta asset leads to higher R-squared values, lower Sharpe ratios of alphas, and fewer significant pricing errors in the time-series analysis. Similarly, the pricing of small stock and industry portfolios is improved. In cross-section, we also find improved results, with fewer cross-sectional pricing errors and more economically meaningful pricing of risk factors. We also find that a zero-beta gold factor constructed to be orthogonal to the Carhart four factors is significant in cross-section and helps to improve factor model performance on momentum portfolios. Furthermore, the Fama–French three- and five-factor asset pricing models and the Carhart model are all improved by these means, particularly on test assets which have been poorly priced by the traditional versions. Our results have salient implications for policymakers, governments, central bank rate-setting decisions, and investors.
Smart Cities and Homes: Current Status and Future Possibilities
Authors: Mukhopadhyay Subhas , Suryadevara Nagender Kumar
Published: March 2023

The advancement of sensing technologies, embedded systems, wireless communication technologies, nanomaterials, miniaturization, vision sensing and processing speed have made it possible to develop smart technologies that can generate data seamlessly [...]
How Effective Risk Assessment and Management Is the Key to Turning Volcanic Islands into a Source of Nature-Based Solutions
Authors: López-Saavedra Marta , Martí Joan , Planagumà Llorenç
Published: March 2023

Active volcanic islands are particularly vulnerable to multi-risk natural hazards, many of which are anticipated to become more severe as a result of climate change. It is crucial to create and put into action adequate risk mitigation plans based on comprehensive long-term hazard assessments that include nature-based solutions in order to improve societal safety on these islands. Herein, we study the case of Tenerife. After a compilation and analysis of the potential resources of this island, as well as a study of its main natural hazards and how they are currently managed, we have determined that the most viable solutions are nature-based ones. Land management based on prior assessment of the island’s hazards is the key to strengthening Tenerife’s current risk mitigation plans. This will allow for a two-way relationship between the exploitation of sustainable tourism and the education of its population, both oriented toward the conservation of its geological heritage, and will promote the sustainable use of the energy and material resources currently being exploited. This contribution thus establishes the pillars from which to exploit the nature-based solutions offered by Tenerife as the only viable option for its sustainable economic development.
Novel Dual Endothelin Inhibitors in the Management of Resistant Hypertension
Authors: Boutari Chrysoula , Siskos Fotios
Published: March 2023

Resistant hypertension (RH) is defined as the failure to achieve blood pressure control despite using triple combination therapy with a renin-angiotensin system inhibitor (RAS-i), a calcium antagonist, and a diuretic. The endothelin (ET) system is implicated in the regulation of vascular tone, primarily through vasoconstriction, intervenes in cardiac contractility with inotropic effects, and contributes to water and sodium renal reabsorption. ET inhibitors, currently approved for the treatment of pulmonary hypertension, seem to be also useful for essential hypertension and RH as well. Studies into the development of new dual ET inhibitors, which inhibit both type A and B ET (ETA and ETB) receptors, present initial results of managing RH. Aprocitentan (ACT-132577) is a novel, orally active and well tolerated dual ET receptor antagonist, which has been examined in several experimental studies and clinical trials with promising results for RH control. The recent publication of the large PRECISION study in The Lancet journal provides further reassurance regarding the efficacy and safety of aprocitentan for RH, with the aim of overcoming unmet needs in the management of this difficult group of patients.
A Size-Dependent Finite Element Method for the 3D Free Vibration Analysis of Functionally Graded Graphene Platelets-Reinforced Composite Cylindrical Microshells Based on the Consistent Couple Stress Theory
Authors: Wu Chih-Ping , Tan Tech-Fatt , Hsu Hao-Ting
Published: March 2023

Within a framework of the consistent couple stress theory (CCST), a size-dependent finite element method (FEM) is developed. The three-dimensional (3D) free vibration characteristics of simply-supported, functionally graded (FG) graphene platelets (GPLs)-reinforced composite (GPLRC) cylindrical microshells are analyzed. In the formulation, the microshells are artificially divided into numerous finite microlayers. Fourier functions and Hermitian C2 polynomials are used to interpolate the in-surface and out-of-surface variations in the displacement components induced in each microlayer. As a result, the second-order derivative continuity conditions for the displacement components at each nodal surface are satisfied. Five distribution patterns of GPLs varying in the thickness direction are considered, including uniform distribution (UD) and FG A-type, O-type, V-type, and X-type distributions. The accuracy and convergence of the CCST-based FEM are validated by comparing the solutions it produces with the exact and approximate 3D solutions for FG cylindrical macroshells reported in the literature, for which the material length scale parameter is set at zero. Numerical results show that by increasing the weight fraction of GPLs by 1%, the natural frequency of FG-GPLRC cylindrical microshells can be increased to more than twice that of the homogeneous cylindrical microshells. In addition, the effects of the material length scale parameter, the GPL distribution patterns, and the length–to–thickness ratio of GPLs on natural frequencies of the FG-GPLRC cylindrical microshells are significant.
Study on the Performance of Recycled Coarse and Fine Aggregates as Microbial Carriers Applied to Self-Healing Concrete
Authors: Duan Zhenhua , Lv Zhenyuan , Xiao Jianzhuang , Liu Chao , Nong Xiangyun
Published: March 2023

The contradiction between the scarcity of natural resources and the demand for construction materials has given rise to the application of recycled aggregates. Microbial self-healing concrete (SHC) is a clean and smart material, and its carrier has a great influence on repair performance. In this paper, recycled coarse aggregate (RCA) and recycled fine aggregate (RFA) were used as carriers, and their different repair effects over time were intensively investigated. The results showed that the RCA carrier had a better repair effect compared with that of RFA, and the maximum healing width could reach 0.27 mm by 28 day. The microbial repair efficiency was significantly influenced by the distribution of old mortar, with the RFA specimen having a small volume and wide distribution of repair products, while the RCA repair showed a centralized tendency. In addition, SEM, MIP and XRD characterization were used to analyze the repair mechanism. The time-dependent repair model was developed, and the applicability of the model for concrete enhancement under microbial repair was verified through experimental results. The research results could promote industrial applications by giving intelligent and green properties to recycled aggregates.
High-Strength Ductility Joining of Multicomponent Alloy to 304 Stainless Steel Using Laser Welding Technique
Authors: Wang Junjie , Peng Fei , Zhou Li , Luo Yajun , Zhang Weidong , Wu Zhenggang
Published: March 2023

In this work, a series of multicomponent alloys (CoCrFeNi, CoCrNi, and CoNiV) were laser welded with 304 stainless steel (304ss), and detailed comparisons on microstructural characteristics and mechanical properties were conducted for dissimilar laser welded joints. It is revealed that all of the dissimilar laser welded samples possessed defect-free joints and the corresponding fusion zone consisting of fcc single-phase showed homogeneous element distribution accompanied by a narrow element gradient in the vicinity of the fusion zone boundary. After laser welding with identical welding parameters, equiaxed grain was observed on the side of multicomponent alloy, while coarse columnar grain was obtained on the side of 304ss. Especially, the columnar grains of the fusion zone on the side of 304ss disclosed preferential <001> growth direction in the CoCrFeNi/304ss and CoCrNi/304ss welded joints. Furthermore, all of the dissimilar laser welded joints were fractured in the fusion zone, attributing to the drastic loss of strength in the fusion zone with coarsened grain. It is worth noting that a special lamellar structure that merged by dimples was found in the fracture surface of the CoNiV/304ss joint, closely related to the existence of the V-enriched region. Finally, a high strength–ductile synergy can be achieved by laser welding CoNiV alloy to 304ss, which showed a yield strength of 338 MPa, ultimate tensile strength of 686 MPa, and total elongation of 28.9%. These excellent mechanical properties prevailed in the potential of a CoNiV/304ss laser welded joint to be applied as a structural material.
Efficacy Ozone Therapy in Reducing Periodontal Disease
Authors: Tetè Giulia , D’Amicantonio Teresa , Polizzi Elisabetta
Published: March 2023

The aim of this study is to highlight the properties of ozone as an aid to non-surgical therapy compared to non-surgical therapy alone. This study included thirty Caucasian patients (eighteen women and twelve men) aged between 35 and 65, recruited at the Oral Hygiene and Prevention Center of the Dental Clinic of the Vita-Salute San Raffaele University, at the San Raffaele hospital in Milan. The periodontal probing was recorded with a PC-PUNC 15 manual probe (Hu Friedy) at time 0; the scaling and root planing session was performed at T1 with or without the aid of ozone therapy, and then, the patients were re-evaluated at one month (T2), three months (T3), and six months (T4). The results obtained show that there are not statistically significant differences in terms of reduction in clinical periodontal indices such as plaque, bleeding, and pocket depth between the two groups. Therefore, treatment with ozoral gel would not seem to improve non-surgical periodontal therapy alone. However, clinical periodontal indices significantly improved in patients treated with non-surgical therapy and ozone gel. From this point of view, ozone gel can be used as an aid to non-surgical therapy due to its excellent characteristics, in particular, its powerful virucidal action.
Platinum Metallization of Polyethylene Terephthalate by Supercritical Carbon Dioxide Catalyzation and the Tensile Fracture Strength
Authors: Cheng Po-Wei , Kurioka Tomoyuki , Chen Chun-Yi , Chang Tso-Fu Mark , Chiu Wan-Ting , Hosoda Hideki , Takase Kei , Ishihata Hiroshi , Kurosu Hiromichi , Sone Masato
Published: March 2023

Polyethylene terephthalate (PET) is known to be highly inert, and this makes it difficult to be metallized. In addition, Pt electroless plating is rarely reported in the metallization of polymers. In this study, the metallization of biocompatible Pt metal is realized by supercritical CO2 (sc-CO2)-assisted electroless plating. The catalyst precursor used in the sc-CO2 catalyzation step is an organometallic compound, palladium (II) acetylacetonate (Pd(acac)2). The electrical resistance is evaluated, and a tape adhesion test is utilized to demonstrate intactness of the Pt layer on the PET film. The electrical resistance of the Pt/PET with 60 min of the Pt deposition time remains at a low level of 1.09 Ω after the adhesion test, revealing positive effects of the sc-CO2 catalyzation step. A tensile test is conducted to evaluate the mechanical strength of the Pt/PET. In-situ electrical resistances of the specimen are monitored during the tensile test. The fracture strength is determined from the stress value when the short circuit occurred. The fracture strength is 33.9 MPa for a specimen with 30 min of the Pt deposition time. As the Pt deposition time increases to 45 min and 60 min, the fracture strengths reach 52.3 MPa and 65.9 MPa, respectively. The promoted fracture strength and the decent electrical conductivity demonstrate the advantages toward biomedical devices.
Biomechanical Behavior Evaluation of Resin Cement with Different Elastic Modulus on Porcelain Laminate Veneer Restorations Using Micro-CT-Based Finite Element Analysis
Authors: Mert Eren Meltem , Celebi Alper Tunga , İçer Esra , Baykasoğlu Cengiz , Mugan Ata , Yücel Taner , Yıldız Esra
Published: March 2023

The aim of this study is to evaluate the biomechanical behavior of the porcelain laminate veneer restorations (PLV) of the maxillary central incisor luted with two types of resin cements having different incisal preparations: butt joint and palatal chamfer. Biomechanical analyses were performed using the micro-CT-based finite element models, and von Mises stress and strain values of the PLV, resin cement, adhesive layer, and tooth structure were computed. The PLV with butt joint preparation showed larger stress values than those of restored with palatal chamfer preparation, regardless of the elasticity of the cement and loading conditions. An increase in the elasticity modulus of the resin cement induced slightly larger stresses on the adhesive layer, tooth tissues, and restorative materials. Overall, this study demonstrates the role of the preparation design and luting materials on the mechanical behavior of the PLV restorations and discusses the potential failure mechanisms of the PLV restorations under different loading mechanisms.
The Use of Trigonometric Series for the Study of Isotropic Beam Deflection
Authors: Botean Adrian Ioan
Published: March 2023

The average deformed fiber is a continuous and smooth function of the fourth order. The deflection and rotation of beams can be determined by various methods available in the literature. Thus, in this paper, the expression of the average deformed fiber is defined in advance, then it is considered an infinite sum of sinusoidal functions that are successively evaluated using sinusoidal trigonometric series if it is considered a periodic function, or using Fourier series if it is considered a non-periodic function. The method is examined by solving several beam problems. The results indicate that the method can be used with confidence for solving any bending beam problem.
Mixed Convection in a Horizontal Channel–Cavity Arrangement with Different Heat Source Locations
Authors: Rashid Farhan Lafta , Al-Gaheeshi Asseel M. Rasheed , Alhwayzee Mohammed , Ali Bagh , Shah Nehad Ali , Chung Jae Dong
Published: March 2023

Several researchers are very interested in mixed convection heat transfer because of how widely it is used, particularly for solar thermal collectors, cooling electronic equipment, and chemical process instruments. Using COMSOL-Multiphysics, this article establishes laminar coupled mixed convection heat transfer characteristics across a horizontal channel–cavity architecture. Investigations are conducted into the effect of heat source location on isotherms, velocity distribution, pressure, temperature, average and local Nusselt numbers, and air density. The intake airflow Reynolds number is assumed constant on 2.8814. The enclosure with an isothermally heated right wall in the shape of a “<” as a heat source in three configurations (heat source in the base (1st case), in the upper step (2nd case), and the below step (3rd case). The obtained numerical results present that the higher heat transfer is performed in case two because the heat source is near the contact surface between the channel and the cavity. With the hot sources’ locations being altered, the velocity distribution seems to be unchanged. The increase in the positive y axis has no impact on the pressure distribution throughout the channel. Changing the position of the heated source does not seem to have any impact on the pressure distribution. Air density profiles start to diverge across cases around y = 0.035 m; the third example has a larger value than the second case, and the latter case has a larger value in the density distribution than the former. The contact between the enclosure and the channel (y = 0), where the greatest Nusselt number also occurs, exhibits the highest heat transfer. The maximal Nusselt number falls as y’s absolute value rises.
A Nonlinear System of Generalized Ordered XOR-Inclusion Problem in Hilbert Space with S-Iterative Algorithm
Authors: Ali Imran , Rizvi Haider Abbas , Geetha Ramakrishnan , Wang Yuanheng
Published: March 2023

In this article, a nonlinear system of generalized ordered XOR-inclusion problems in Hilbert space is introduced and studied. Initially, we define the resolvent operator related to the (α,λ)-XOR-weak-ANODD multivalued mapping. Using the fixed point technique, we demonstrate the results of existence. In order to make the suggested system more realistic, we create the S-iterative algorithm and demonstrate that the sequence generated through this technique strongly converges with the proposed system’s solution. One example is provided in support of the existence result as well.
Modeling COVID-19 Using a Modified SVIR Compartmental Model and LSTM-Estimated Parameters
Authors: Wyss Alejandra , Hidalgo Arturo
Published: March 2023

This article presents a modified version of the SVIR compartmental model for predicting the evolution of the COVID-19 pandemic, which incorporates vaccination and a saturated incidence rate, as well as piece-wise time-dependent parameters that enable self-regulation based on the epidemic trend. We have established the positivity of the ODE version of the model and explored its local stability. Artificial neural networks are used to estimate time-dependent parameters. Numerical simulations are conducted using a fourth-order Runge–Kutta numerical scheme, and the results are compared and validated against actual data from the Autonomous Communities of Spain. The modified model also includes explicit parameters to examine potential future scenarios. In addition, the modified SVIR model is transformed into a system of one-dimensional PDEs with diffusive terms, and solved using a finite volume framework with fifth-order WENO reconstruction in space and an RK3-TVD scheme for time integration. Overall, this work demonstrates the effectiveness of the modified SVIR model and its potential for improving our understanding of the COVID-19 pandemic and supporting decision-making in public health.
Pro-Apoptotic Activity of Bioactive Compounds from Seaweeds: Promising Sources for Developing Novel Anticancer Drugs
Authors: Agena Rosette , de Jesús Cortés-Sánchez Alejandro , Hernández-Sánchez Humberto , Jaramillo-Flores María Eugenia
Published: March 2023

The process by which cancer cells evade or inhibit apoptosis is considered one of the characteristics of cancer. The ability of cancer cells to escape apoptosis contributes to tumor proliferation and promotes metastasis. The discovery of new antitumor agents is essential for cancer treatment due to the lack of selectivity of drugs and cellular resistance to anticancer agents. Several studies showed that macroalgae produce various metabolites with different biological activities among marine organisms. This review discusses multiple metabolites extracted from macroalgae and their pro-apoptotic effects through regulating apoptosis signaling pathway target molecules and the structure-activity relationship. Twenty-four promising bioactive compounds have been reported, where eight of these compounds exhibited values of maximum inhibitory concentration (IC50) of less than 7 μg/mL. Fucoxanthin was the only carotenoid reported that induced apoptosis in HeLa cells with an IC50 below 1 µg/mL. Se-PPC (a complex of proteins and selenylated polysaccharides) is the magistral compound because it is the only one with an IC50 of 2.5 µg/mL which regulates the primary proteins and critical genes of both apoptosis pathways. Therefore, this review will help provide the basis for further studies and the development of new anticancer drugs, both as single agents and adjuvants, decreasing the aggressiveness of first-line drugs and offering patients better survival and quality of life.
Enhanced Separation of Sulfur and Metals from Polymetallic Sulfur Slag through Recrystallizing Regulation of Sulfur Crystals
Authors: Chen Fanyun , Gao Qingshan , Zhang Jing , Deng Hao , Tian Chen , Lin Zhang
Published: March 2023

Elemental sulfur is an important non-metallic material that is widely used in various fields including chemical, metallurgical and sulfuric acid industries. Polymetallic sulfur slag (PSS) is an important secondary resource for the recovery of sulfur. However, separation of sulfur from PSS is difficult due to the tight binding of some thiophilic metals to sulfur. Herein, we proposed a recrystallization method for the effective separation of sulfur and metals by using organic solvents to control the particle size of sulfur crystals. It was suggested that the particle size of sulfur recovered in the close to saturation state of toluene is about 2000 μm, while the purity is as high as 99.6%. Moreover, the recovery rate is over 95%, which is more than the current commonly used flotation method. The growth mechanism of sulfur crystals under different saturation conditions lays a foundation for the deepening of the growth theory of large-size sulfur crystals. This method realized the effective separation of sulfur from metal sulfides such as FeS2 and ZnS, which provided an important guidance for the recovery of sulfur resources through a novel method of recrystallizing regulation.
Characterization of Two Novel Rumen-Derived Exo-Polygalacturonases: Catalysis and Molecular Simulations
Authors: Deng Qian , Sun Xiaobao , Gao Deying , Wang Yuting , Liu Yu , Li Nuo , Wang Zhengguang , Liu Mingqi , Wang Jiakun , Wang Qian
Published: March 2023

Pectinases are a series of enzymes that degrade pectin and have been used extensively in the food, feed, and textile industries. The ruminant animal microbiome is an excellent source for mining novel pectinases. Two polygalacturonase genes, IDSPga28-4 and IDSPga28-16, from rumen fluid cDNA, were cloned and heterologously expressed. Recombinant IDSPGA28-4 and IDSPGA28-16 were stable from pH 4.0 to 6.0, with activities of 31.2 ± 1.5 and 330.4 ± 12.4 U/mg, respectively, against polygalacturonic acid. Hydrolysis product analysis and molecular dynamics simulation revealed that IDSPGA28-4 was a typical processive exo-polygalacturonase and cleaved galacturonic acid monomers from polygalacturonic acid. IDSPGA28-16 cleaved galacturonic acid only from substrates with a degree of polymerization greater than two, suggesting a unique mode of action. IDSPGA28-4 increased the light transmittance of grape juice from 1.6 to 36.3%, and IDSPGA28-16 increased the light transmittance of apple juice from 1.9 to 60.6%, indicating potential application in the beverage industry, particularly for fruit juice clarification.
Evaluation of Biofilm Cultivation Models for Efficacy Testing of Disinfectants against Salmonella Typhimurium Biofilms
Authors: Richter Anja M. , Konrat Katharina , Osland Ane M. , Brook Emma , Oastler Claire , Vestby Lene K. , Gosling Rebecca J. , Nesse Live L. , Arvand Mardjan
Published: March 2023

Within the European Union, Salmonella is frequently reported in food and feed products. A major route of transmission is upon contact with contaminated surfaces. In nature, bacteria such as Salmonella are often encountered in biofilms, where they are protected against antibiotics and disinfectants. Therefore, the removal and inactivation of biofilms is essential to ensure hygienic conditions. Currently, recommendations for disinfectant usage are based on results of efficacy testing against planktonic bacteria. There are no biofilm-specific standards for the efficacy testing of disinfectants against Salmonella. Here, we assessed three models for disinfectant efficacy testing on Salmonella Typhimurium biofilms. Achievable bacterial counts per biofilm, repeatability, and intra-laboratory reproducibility were analyzed. Biofilms of two Salmonella strains were grown on different surfaces and treated with glutaraldehyde or peracetic acid. Disinfectant efficacy was compared with results for planktonic Salmonella. All methods resulted in highly repeatable cell numbers per biofilm, with one assay showing variations of less than 1 log10 CFU in all experiments for both strains tested. Disinfectant concentrations required to inactivate biofilms were higher compared to planktonic cells. Differences were found between the biofilm methods regarding maximal achievable cell numbers, repeatability, and intra-laboratory reproducibility of results, which may be used to identify the most appropriate method in relation to application context. Developing a standardized protocol for testing disinfectant efficacy on biofilms will help identify conditions that are effective against biofilms.
The Early Paleocene Ranikot Formation, Sulaiman Fold-Thrust Belt, Pakistan: Detrital Zircon Provenance and Tectonic Implications
Authors: Qasim Muhammad , Ashraf Junaid , Ding Lin , Tanoli Javed Iqbal , Khan Imran , Rehman Mohib Ur , Awais Muhammad , Ahmad Jalil , Tayyab Owais , Jadoon Ishtiaq Ahmad Khan
Published: March 2023

This study reports on the detrital zircon provenance of the sandstones of Early Paleocene Ranikot Formation exposed in the Fort Munro section, Sulaiman fold-thrust belt, Pakistan. This marks the Cretaceous-Tertiary boundary sequence. The detrital zircon U-Pb ages reported are mainly clustered around ~460–1100 Ma, ~1600–1900 Ma and ~2300–2600 Ma. The age cluster ~460–1100 Ma is mainly matched well with the Tethyan Himalaya. However, the age clusters ~1600–1900 Ma and ~2300–2600 Ma matched fairly with the lesser Himalayas and Higher Himalayas. In addition, the sandstone petrography suggests the craton interior provenance. The two younger Cretaceous zircon ages may be derived from the Tethyan Himalaya volcanic rocks as supported by a high (>0.3) Th/U ratio. Furthermore, the absence of the ophiolitic component ~115–178 Ma suggests that the western ophiolite may be emplaced at the same time as Ranikot Formation deposited or later. Moreover, the absence of the Eurasian (zircon with ages <100 Ma) in the Ranikot Formation excludes the possibility of the early collision along the western margin, as reported in earlier studies.
Recent Advances in the Synthesis of Borinic Acid Derivatives
Authors: Boyet Marion , Chabaud Laurent , Pucheault Mathieu
Published: March 2023

Borinic acids [R2B(OH)] and their chelate derivatives are a subclass of organoborane compounds used in cross-coupling reactions, catalysis, medicinal chemistry, polymer or optoelectronics materials. In this paper, we review the recent advances in the synthesis of diarylborinic acids and their four-coordinated analogs. The main strategies to build up borinic acids rely either on the addition of organometallic reagents to boranes (B(OR)3, BX3, aminoborane, arylboronic esters) or the reaction of triarylboranes with a ligand (diol, amino alcohol, etc.). After general practical considerations of borinic acids, an overview of the main synthetic methods, their scope and limitations is provided. We also discuss some mechanistic aspects.
Advances in Semiconductor-Based Nanocomposite Photo(electro)catalysts for Nitrogen Reduction to Ammonia
Authors: Zuo Cheng , Su Qian
Published: March 2023

Photo(electro)catalytic nitrogen fixation technology is a promising ammonia synthesis technology using clean solar and electric energy as the driving energy. Abundant nitrogen and water as raw materials uphold the principle of green and sustainable development. However, the generally low efficiency of the nitrogen reduction reaction has seriously restricted the application and development of this technology. The paper introduces the nitrogen reduction process and discusses the main challenges and differences in the current photo(electro)catalytic nitrogen fixation systems. It focuses on promoting the adsorption and activation of N2 and the resolution and diffusion of NH3 generated. In recent years, reviews of the modification strategies of semiconductor materials in light of the typical cases of nitrogen fixation have been reported in the literature. Finally, the future development trend of this field is analyzed and prospected.
Purification and Structure Characterization of the Crude Polysaccharide from the Fruiting Bodies of Butyriboletus pseudospeciosus and Its Modulation Effects on Gut Microbiota
Authors: Tian Run , Wu Lu-Ling , Li Hong-Fu , Liang Zhi-Qun , Li Pei-Hu , Wang Yong , Zeng Nian-Kai
Published: March 2023

Polysaccharides from the species of Boletaceae (Boletales, Agaricomycetes, Basidiomycota) are economically significant to both functional foods and medicinal industries. The crude polysaccharide from Butyriboletus pseudospeciosus (BPP) was prepared, and its physicochemical properties were characterized through the use of consecutive experimental apparatus, and its impact on the gut microbiota of Kunming mice was evaluated. Analyses of the structure characteristics revealed that BPP was mainly composed of Man, Glc, and Gal, possessing the pyranose ring and β/α-glycosidic linkages. TG analysis exhibited that BPP had great heat stability. The SEM observation performed demonstrated that BPP appeared with a rough, dense, and porous shape. Through the BPP intervention, the serum and fecal biochemical index in mice can be improved obviously (p < 0.05). The abundance of beneficial microbiota in the BPP-treated group was significantly increased, while the abundance of harmful microbiota was significantly decreased (p < 0.05). Based on the Tax4Fun, we also revealed the relationship between the species of gut microbiota and showed that the high dose of BPP has significantly changed the functional diversities compared with those in other groups (p < 0.05). The results suggest that B. pseudospeciosus could serve as potential functional food or medicine.
Toward Creating Software Architects Using Mobile Project-Based Learning Model (Mobile-PBL) for Teaching Software Architecture
Authors: Al-Qora’n Lamis F. , Jawarneh Ali , Nganji Julius T.
Published: March 2023

Project-based learning (PBL) promotes increased levels of learning, deepens student understanding of acquired knowledge, and improves learning motivation. Students develop their ability to think and learn independently through depending on themselves in searching for knowledge, planning, exploration, and looking for solutions to practical problems. Information availability, student engagement, and motivation to learn all increase with mobile learning. The teaching process may be enhanced by combining the two styles. This paper proposes and evaluates a teaching model called Mobile Project-Based Learning (Mobile-PBL) that combines the two learning styles. The paper investigates how significantly Mobile-PBL can benefit students. The traditional lecture method used to teach the software architecture module in the classroom is not sufficient to provide students with the necessary practical experience to earn a career as software architects in the future. Therefore, the first author tested the use of the model for teaching the software architecture module at Philadelphia University’s Software Engineering Department on 62 students who registered for a software architecture course over three semesters. She compared the results of using the model for teaching with those results that were obtained when using the project-based learning (PBL) approach alone. The students’ opinions regarding the approach, any problems they had, and any recommendations for improvement were collected through a focus group session after finishing each semester and by distributing a survey to students to evaluate the effectiveness of the used model. Comments from the students were positive, according to the findings. The projects were well-received by the students, who agreed that it gave them a good understanding of several course ideas and concepts, as well as providing them with the required practical experience. The students also mentioned a few difficulties encountered while working on the projects, including student distraction from social media and the skills that educators and learners in higher education institutions are expected to have.
Chemical Vapor Transport Synthesis of Fibrous Red Phosphorus Crystal as Anodes for Lithium-Ion Batteries
Authors: Liu Lei , Gao Xing , Cui Xuemei , Wang Bofeng , Hu Fangzheng , Yuan Tianheng , Li Jianhua , Zu Lei , Lian Huiqin , Cui Xiuguo
Published: March 2023

Red phosphorus (RP) is considered to be the most promising anode material for lithium-Ion batteries (LIBs) due to its high theoretical specific capacity and suitable voltage platform. However, its poor electrical conductivity (10−12 S/m) and the large volume changes that accompany the cycling process severely limit its practical application. Herein, we have prepared fibrous red phosphorus (FP) that possesses better electrical conductivity (10−4 S/m) and a special structure by chemical vapor transport (CVT) to improve electrochemical performance as an anode material for LIBs. Compounding it with graphite (C) by a simple ball milling method, the composite material (FP-C) shows a high reversible specific capacity of 1621 mAh/g, excellent high-rate performance and long cycle life with a capacity of 742.4 mAh/g after 700 cycles at a high current density of 2 A/g, and coulombic efficiencies reaching almost 100% for each cycle.
WO3 Nanorods Decorated with Very Small Amount of Pt for Effective Hydrogen Evolution Reaction
Authors: Mineo Giacometta , Bruno Luca , Bruno Elena , Mirabella Salvo
Published: March 2023

The electrochemical hydrogen evolution reaction (HER) is one of the most promising green methods for the efficient production of renewable and sustainable H2, for which platinum possesses the highest catalytic activity. Cost-effective alternatives can be obtained by reducing the Pt amount and still preserving its activity. The Pt nanoparticle decoration of suitable current collectors can be effectively realized by using transition metal oxide (TMO) nanostructures. Among them, WO3 nanorods are the most eligible option, thanks to their high stability in acidic environments, and large availability. Herein, a simple and affordable hydrothermal route is used for the synthesis of hexagonal WO3 nanorods (average length and diameter of 400 and 50 nm, respectively), whose crystal structure is modified after annealing at 400 °C for 60 min, to obtain a mixed hexagonal/monoclinic crystal structure. These nanostructures were investigated as support for the ultra-low-Pt nanoparticles (0.2–1.13 μg/cm2): decoration occurs by drop casting some drops of a Pt nanoparticle aqueous solution and the electrodes were tested for the HER in acidic environment. Pt-decorated WO3 nanorods were characterized by performing scanning electron microscopy (SEM), X-ray diffraction analysis (XRD), Rutherford backscattering spectrometry (RBS), linear sweep voltammetry (LSV), electrochemical impedance spectroscopy (EIS) and chronopotentiometry. HER catalytic activity is studied as a function of the total Pt nanoparticle loading, thus obtaining an outstanding overpotential of 32 mV at 10 mA/cm2, a Tafel slope of 31 mV/dec, a turn-over frequency of 5 Hz at −15 mV, and a mass activity of 9 A/mg at 10 mA/cm2 for the sample decorated with the highest Pt amount (1.13 μg/cm2). These data show that WO3 nanorods act as excellent supports for the development of an ultra-low-Pt-amount-based cathode for efficient and low-cost electrochemical HER.
Role of Polyanions and Surfactant Head Group in the Formation of Polymer–Colloid Nanocontainers
Authors: Vasilieva Elmira A. , Kuznetsova Darya A. , Valeeva Farida G. , Kuznetsov Denis M. , Zakharova Lucia Ya.
Published: March 2023

Objectives. This study was aimed at the investigation of the supramolecular systems based on cationic surfactants bearing cyclic head groups (imidazolium and pyrrolidinium) and polyanions (polyacrylic acid (PAA) and human serum albumin (HSA)), and factors governing their structural behavior to create functional nanosystems with controlled properties. Research hypothesis. Mixed PE–surfactant complexes based on oppositely charged species are characterized by multifactor behavior strongly affected by the nature of both components. It was expected that the transition from a single surfactant solution to an admixture with PE might provide synergetic effects on structural characteristics and functional activity. To test this assumption, the concentration thresholds of aggregation, dimensional and charge characteristics, and solubilization capacity of amphiphiles in the presence of PEs have been determined by tensiometry, fluorescence and UV-visible spectroscopy, and dynamic and electrophoretic light scattering. Results. The formation of mixed surfactant–PAA aggregates with a hydrodynamic diameter of 100–180 nm has been shown. Polyanion additives led to a decrease in the critical micelle concentration of surfactants by two orders of magnitude (from 1 mM to 0.01 mM). A gradual increase in the zeta potential of HAS–surfactant systems from negative to positive value indicates that the electrostatic mechanism contributes to the binding of components. Additionally, 3D and conventional fluorescence spectroscopy showed that imidazolium surfactant had little effect on HSA conformation, and component binding occurs due to hydrogen bonding and Van der Waals interactions through the tryptophan amino acid residue of the protein. Surfactant–polyanion nanostructures improve the solubility of lipophilic medicines such as Warfarin, Amphotericin B, and Meloxicam. Perspectives. Surfactant–PE composition demonstrated beneficial solubilization activity and can be recommended for the construction of nanocontainers for hydrophobic drugs, with their efficacy tuned by the variation in surfactant head group and the nature of polyanions.