bluuebunny/crossref_metadata_2025 huggingface dataset:
Myxomatous mitral valve disease and associated pulmonary hypertension might increase serum angiopoietin-2 in dogs
Authors: Yu Hogeun , Lee Dohee , Chae Yeon , Choi Minseok , Lee Yelim , Yun Taesik , Kang Byeong-Teck , Yang Mhan-Pyo , Kim Hakhyun
Published: March 2024

OBJECTIVE

To evaluate the relationships between the severity of myxomatous mitral valve disease (MMVD) and pulmonary hypertension (PH) and serum angiopoietin (Ang)-1 and Ang-2 concentrations in dogs with MMVD.

ANIMALS

74 dogs (control, n = 12; MMVD, n = 62) were included.

METHODS

Serum Ang-1 and Ang-2 concentrations were estimated using the canine-specific ELISA kit. The concentrations were compared between dogs with MMVD and healthy dogs, and they were analyzed according to the severity of MMVD and PH.

RESULTS

The median serum Ang-1 concentration did not differ among the study groups. The median serum Ang-2 concentration was higher in dogs with stage B2 MMVD (P = .041) and acute congestive heart failure (P = .002) than in control dogs. In addition, the median serum Ang-2 concentration was higher in MMVD dogs with PH than in those without PH (P = .031). Serum Ang-2 concentration was correlated with vertebral heart score (rs = 0.36, P = .004) and vertebral left atrial score (r = 0.50, P < .001) in dogs with MMVD, and correlated with vertebral heart score (r = 0.63, P = .01), maximum E wave amplitude of the diastolic transmitral flow (rs = 0.61, P = .018), ejection fraction (rs = –0.77, P < .001) and fractional shortening (rs = –0.56, P = .032) in dogs with acute congestive heart failure.

CLINICAL RELEVANCE

Circulating Ang-2 levels increase in dogs with the severity of MMVD and the presence of PH.
The Role of Hypothyroidism in the Etiology of Hyponatremia - Case Report and a Short Review
Authors: Anghel Lucretia , Baroiu Liliana , Stefanopol Ioana Anca , Busila Camelia , Ignat Daniela Mariana , Spalatelu Oana , Bulza Valentin
Published: March 2024

Hyponatremia induced by hypothyroidism is a rare phenomenon and a correlation between them can be argued only with possible mechanisms. Hyponatremia often results from the concomitant development of several overlapping pathological events. The association between hypothyroidism and hyponatremia should be considered only if explanations for any other etiological causes have been exhausted. We present the case of a female patient aged 67 years who has previously undergone surgery for a meningioma and who presented with symptoms such as nausea, biliary vomiting, headache and epigastric pain. Laboratory results indicated multiple electrolyte imbalances, including hyponatremia, but the brain imaging studies did not confirm cerebral edema or the presence of tumor development. Under electrolytic correction treatment which was supplemented with L-thyroxine, the biochemical parameters were corrected and normalized and the patient was relieved of her symptoms. This case thus raises the possibility that hyponatremia could be induced or at least precipitated by hypothyroidism. Thyroid dysfunction tests should be targeted in cases of hyponatremia with non-specific causes, even if hypothyroidism is rarely the cause.
Empowerment in chronic wound care—exploring the scope for patient contribution†
Authors: Hackert Benedikt , Stürmer Ewa Klara , Weger Ulrich
Published: March 2024

Objective

In this study, we investigated the concept of empowerment in chronic wound care and propose to facilitate patient control by making use of degrees of freedom (DOF): that is, shaping of everyday wound care tasks initiated by patients and based on their wishes, mostly in terms of patients executing treatment steps, requesting or directing health care professionals to undertake changes, or modifications of internal states.

Methods

As a first step, we conducted a systematic literature search, followed by an inductive form of qualitative content analysis, which resulted in the identification of 5 dimensions as main elements of empowerment: education and shared decision making, adherence to self-care behaviors, responsibility and control, general call for empowerment, and DOF. However, the latter are noticeably absent in the literature. To investigate patients’ freedom in shaping the wound care process, we conducted a second literature search.

Results

A number of possibilities for patients to influence the wound care process could be identified, but experimental or clinical evidence about their effects is missing, their variety is limited, and they are only inadequately described.

Conclusions

However, DOF should be an indispensable aspect of genuine empowerment, since they allow patients to occupy the role of the agent in the treatment process and give rise to the subjective experience of feeling empowered. Thus, in the third part, we develop a research proposal on how to investigate and include DOF in the clinical practice of wound care. Finally, limitations about implementations are discussed (e.g., patients being reluctant to overcome their passive role, resulting in frustration for health care professionals).
Irregular dietary habits as a predictor of stunting occurrence among children under 5 years of age: a literature review
Authors: Risnah  , Huriati  , Hadrayani Eka , Arbianingsih  , Muthahharah  , Nurhidayah  , Purwanti Sally
Published: March 2024

Objective

To identify the illustration of feeding patterns of stunting children using literature review method.

Methods

This study was a descriptive narrative research using literature review approach to explore dietary habits of children with stunting problem. All the literature review processes employed Guideline Review measurement of Joanna Briggs Institute. Related articles in literature were obtained from journal databases, such as PubMed, ScienceDirect, Google Scholar, and Dimensions through structured research question with Patient, Exposure an interest, Outcome or response (PEO) methods.

Results

This study found 2246 published articles from 2018 to 2021 about children with stunting. Screening process was conducted further to eliminate articles with irrelevant titles and abstracts, and also the unsuitable articles with the research question; hence, about 9 articles were eligible to be reviewed ahead. All these articles mentioned that children with irregular dietary habits would likely experience stunting. The low intake of nutritional food became the major predictor of stunting.

Conclusions

Inappropriate feeding patterns and the variety of food were being the factors of stunting emergence among children <5 years of age. High consumption of carbohydrates, less animal-based protein, and misunderstanding about intake of sweetened-condensed milk predisposed children to suffer stunting.
Nursing student volunteers and their level of involvement during the COVID-19 pandemic: a systematic review
Authors: Fithriyyah Yayu Nidaul , Alim Syahirul
Published: March 2024

Objective

Many strategic efforts were made to address nurses’ shortage in controlling Coronavirus disease 2019 (COVID-19), including recruiting student health volunteers. This review aimed to explore the contribution and involvement of nursing student volunteers during COVID-19.

Methods

A systematic review was registered in PROSPERO International CRD42021283069. Electronic databases for article search included: SCOPUS, EBSCO MEDLINE, PubMed, ProQuest, Springer, Sage Pub, and hand searching. The critical appraisal study quality using The Joanna Briggs Institutes. Data extraction and synthesis used Population, Intervention, Comparison, Outcome, and Design (PICO and D) framework with thematic analysis.

Results

Twelve studies were enrolled from 2545 retrieved, with 4 synthesized themes: (1) determinant of the involvement of nursing student volunteers during COVID-19, which includes 3 subthemes: motivations, perception, and barriers, (2) expectations and actual condition of nursing students as volunteers, (3) the need for nursing student volunteers, and (4) the impact and level of student volunteers’ contribution. All student volunteers contribute to providing direct or indirect services to patients.

Conclusions

This review provides an overview of nursing student volunteers’ needs useful in developing competency frameworks and the role of culturally sensitive volunteers in education and training. In the future, student volunteers could choose the appropriate volunteer program and location according to their competence.
Nurses’ attitude toward patients’ safety climate during COVID-19 pandemic: a cross-sectional study†
Authors: Nassehi Asra , Ghorbanzadeh Kobra , Moayedi Somaye , Jafari Javad , Mahmoodi Parvin , Jafari Mojtaba
Published: March 2024

Objective

Patient safety is a fundamental factor in improving the quality of care provided in hospitals. Therefore, it is considered a significant parameter by all healthcare organizations around the world. The present study was conducted to investigate the attitude of nurses toward the patient safety climate during the Coronavirus Disease 2019 (COVID-19) pandemic in the southeast of Iran.

Methods

This is a cross-sectional descriptive study. Among all the nurses working in one of the hospitals in the southeast of Iran, 171 nurses participated in the study through convenience sampling methods. The survey was conducted between June 1 and July 30, 2020. A 2-part questionnaire including demographic information and an assessment of nurses’ attitudes toward patients’ safety climate was used for data collection in 2021. The content validity of the scale is (0.77) and reliability was re-calculated and confirmed by the present study with Cronbach’s alpha (α = 0.9). Data were analyzed by SPSS 20 (IBM Corporation, Armonk, New York, United States) using descriptive and analytical statistical tests.

Results

The mean score of safety climates was 3.2 ± 5.20 (out of 5 scores). The results showed that among all dimensions of the safety climate, only the education dimension was statistically significant between males and females (P < 0.001). Also, there was a significant relationship between the overall average of the safety climate and its dimensions according to the people’s position only in the dimension of supervisors’ attitude (P < 0.01) and burnout (P < 0.01). Additionally, a significant correlation between the education level and the overall score of safety climate (P < 0.01), as well as the supervisor’s attitude dimension (P < 0.01), was observed.

Conclusions

The results showed that the safety climate was at a relatively favorable level. Considering the impact of nurses’ attitudes on the safety climate of patients, its improvement seems necessary. It is recommended to design training courses and educate nurses in order to promote a patients safety climate in hospitals.
Factors influencing discharge readiness among patients with mild-to-moderate ischemic stroke: a cross-sectional study
Authors: Wang Li-Fei , Samartkit Niphawan , Masingboon Khemaradee
Published: March 2024

Objective

To describe discharge readiness and determine whether self-efficacy, social support, and the quality of discharge teaching can predict discharge readiness among patients with mild-to-moderate ischemic stroke.

Methods

A total of 120 patients with mild-to-moderate ischemic stroke were recruited using simple random sampling. Five instruments, namely, the Demographic Data Questionnaire, the Chinese version of the Readiness for Hospital Discharge Scale (RHDS_C), the Self-Efficacy for Managing Chronic Disease 6-Item Scale (SES6), the Perceived Social Support Scale (PSSS), and the Quality of Discharge Teaching Scale (QDTS), were used for data collection. Descriptive statistics and standard multiple linear regression were used for data analysis.

Results

The mean score of discharge readiness among patients with mild-to-moderate ischemic stroke was at a moderate level (M = 7.6, SD = 0.92), and 75.8% of the participants felt ready for discharge. Standard multiple linear regression revealed that self-efficacy (β = 0.62, P < 0.001) and the quality of discharge teaching (β = 0.28, P < 0.001) were the influencing factors. However, social support could not predict discharge readiness significantly. All the factors combined explained 64.9% of the variance in discharge readiness.

Conclusions

Intervention programs aimed at improving self-efficacy and the quality of discharge teaching may be helpful in promoting discharge readiness in patients with mild-to-moderate ischemic stroke, especially in coping ability.
Relationship between sleep quality and blood pressure level in nurses performing shift work
Authors: Tsipkalo Antonina , Kozak Kateryna , Marushchak Mariya
Published: March 2024

Objective

The aim of the study was to evaluate the quality of sleep in nurses performing shift work in therapeutic and surgical departments and to establish possible relationships between level of blood pressure (BP) and quality of sleep.

Methods

A total of 20 nurses of the therapeutic departments and 20 nurses of the surgical departments were enrolled in the study. Sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI). BP was measured according to the standard protocol using the Korotkoff method; a sphygmomanometer was used for this twice with an interval of 2 min between 10:00 a.m. and 10:30 a.m. The average value for the 2 indicators was calculated. The diagnosis of essential arterial hypertension (AH) was established according to the recommendations of the European Association of Cardiology and the European Association of Hypertension (2018).

Results

The overall assessment of the sleep quality of the nurses involved in shift work indicates poor sleep quality; this was true in respondents of both the surgical and therapeutic profiles. However, it was observed that the quality of sleep was significantly lower in nurses of the therapeutic departments. Moreover, poor sleep quality was associated with AH, which was diagnosed in 65% of the nurses of the therapeutic departments and 45% of the nurses of the surgical departments, that is, in almost all of the subjects. Herewith, in the nurses of the therapeutic departments, the level of systolic BP exceeded that of the nurses of the surgical departments.

Conclusions

Poor sleep quality is a significant risk factor for AH development and is relevant to nurses performing shift work. Additional clinical studies should be conducted to better understand the mechanisms underlying such adverse cardiometabolic outcomes associated with sleep disorders in the health-sector shift workers.
Education Policy of 3rd Generation Universities
Authors: Jafarov Sarkhan
Published: March 2024

Background: One of the tasks of the education policy of any state is the spread of its influence in the international arena. Today, universities are striving to take and strengthen their positions in the world ranking systems, demonstrating the status and reputation of universities in the global market of educational services. This ranking serves as a guideline for future students and their parents when choosing a place to receive a prestigious education and in the formation of individual trajectories of vocational training.
 
Approach: There are several approaches in the world to determining the criteria for assessing a state's education policy. But despite the differences, they all document the growing role of modern universities in the development of society. In many respects, it is important both in terms of guaranteeing the sustainability of society and in terms of ensuring a breakthrough direction in its development. In contrast to recent times, this role has grown significantly. Due to the fairly conservative and limited social system in its function, such universities become a central link in the development of innovative economies and social spheres - the science that produces the socio-economic development of a particular region, Education, innovation centers, national or as well as global processes.
 
Results: It covers all areas of the university, from cooperation with students to financial and scientific activities. A prime example of such an association is the International Strategy Advisory Service (ISAS 2.0) of the International Association of Universities or Universities (IAU).
 
Conclusions: Around the world, states are trying to stimulate and support these processes. In many countries, this is facilitated by opposition from high-tech companies to the reduction of the final amount of independent basic and applied research, in favor of collaborating with universities on basic research projects.
As part of its innovative activities, University 3.0 is involved in supporting business activities, analysis and consultation by experts from local governments and local authorities, opening facilities, and infrastructure for citizens, monitoring regional development, services to citizens are provided for lifelong learning and support student entrepreneurship projects that take into account the interests of the community.
Pendekatan saintifik dalam pengembangan Kurikulum 2013 PAUD
Authors: Wikaningtyas Asih , Nasir Muhammad
Published: March 2024

The Early Childhood Education (ECE) learning curriculum is a teacher's teaching tool as a learning guide that suits the child's character so that they can compete globally. Innovation is needed in the 2013 Curriculum in the form of curriculum development which is the foundation or basis of education in maximizing aspects of children's development, namely learning with a scientific approach that can stimulate children's thinking abilities, reasoning abilities and analytical abilities. Even though learning through the Independent Curriculum is being promoted, learning with a scientific approach in the 2013 Curriculum is still exciting, especially if presented in the form of educational games which are popular with children. Learning with a scientific approach is very important for children because this learning can increase children's understanding of literacy and numeracy, understand the applicable rules, and have critical reasoning. This research aims to provide information to all ECE educators and parents about the application of learning with a scientific approach in developing the 2013 ECE curriculum. Researchers use library research with a qualitative approach with data collection techniques using documentation. The research subjects are books, articles, or readings and reference sources related to the scientific approach in developing the 2013 ECE Curriculum. The research results found that learning with a scientific approach is very well implemented ECE units because this approach has a child-centred character, develops children's potential, increases children's learning motivation, develops children's attitudes and character, and improves children's communication skills. Apart from that, the scientific approach is designed to actively involve children through the process of asking, observing, gathering information, reasoning or making associations, and communicating it in learning. From the research results, it was concluded that the scientific approach in developing the 2013 ECE curriculum emphasizes the use of scientific methods and approaches that develop critical, creative and innovative thinking skills in early childhood.
Awakening Uniqueness: Branding Strategy of Undisan Rural Tourism in Bangli Regency Through Eco-Experience
Authors: Maheswari A.A. Istri Agung , Gorda Anak Agung Ngurah Oka Suryadinatha , Parasari Nyoman Sri Manik , Pradhana I Putu Dharmawan , Anggreswari Ni Putu Yunita
Published: March 2024

This research article explores the branding strategy of Undisan Rural Tourism in Bangli Regency, with a focus on its success in winning the 3rd Places of Tourism Village Award through an eco-experience. The study utilizes a SWOT (Strengths, Weaknesses, Opportunities, and Threats) analysis to identify and evaluate key factors that contribute to the village's branding strategy. Undisan Rural Tourism embodies a unique blend of natural beauty, cultural heritage, and sustainable practices, making it an exemplary case study for rural tourism development. The research methodology involves qualitative approaches. Primary data is collected through interviews, surveys, and participant observations, while secondary data is gathered from relevant literature, reports, and online sources. The SWOT analysis framework is applied to assess the internal and external factors that influence the branding strategy of Undisan Rural Tourism. The findings of the study reveal several strengths that have contributed to the success of Undisan Rural Tourism. These include its pristine environment, rich cultural heritage, authentic local experiences, and strong community engagement. Additionally, the village has capitalized on opportunities such as increasing demand for sustainable and eco-friendly tourism experiences. However, the research also identifies certain weaknesses and threats that need to be addressed, including limited infrastructure, inadequate marketing efforts, and competition from neighboring tourism destinations. Based on the SWOT analysis, this article proposes strategic recommendations to further enhance the branding strategy of Undisan Rural Tourism. These include improving infrastructure and facilities, expanding marketing efforts through digital platforms, fostering partnerships with local stakeholders, and implementing sustainable practices to preserve the environment. The study concludes that Undisan Rural Tourism's success in winning the 3rd Places of Tourism Village Award can be attributed to its unique branding strategy, which highlights the village's distinctive characteristics and eco-experiences. By addressing the identified weaknesses and capitalizing on existing strengths and opportunities, Undisan Rural Tourism can continue to thrive as a leading destination for sustainable rural tourism, setting an example for other tourism villages in the region
Identification and Preferences of Spa Industry in Bali
Authors: Oka Suryawardani I Gusti Ayu , Wiranatha Agung Suryawan , PETR Christine , Purbanto I Gusti Raka , Yudiastina I Gusti Bagus Arya
Published: March 2024

Wellness tourism allows a person to maintain their personal wellbeing, maintaining health and quality of life. People are more conscious of their wellness during the trip. Spa industry which is part of the wellness tourism are growing rapidly in Bali. The research aimed: i) to analyze characteristics of spa treatment in Bali and preferences of spa treatment by customers, ii) to identify products and services provided by traditional and Thalasso Spa in Bali.  Research was conducted in Kuta, Seminyak, Canggu, Nusa Dua and Ubud as the center of spa treatment in Bali. Data was collected on January to April 2023 through interviewing 38 spa industries by using interview guides. Likert Scale was used to analyze the data in 1–5 scale.  Data was analyzed by using qualitative approach.  The results show that traditional spa treatments in Bali provide variety of products such as scrub, cream and lotion from herbs and natural ingredients from agriculture. Type of services available are traditional massage, aromatherapy, Thai massage, reflexology, hot stone massage and hot oil massage. Meanwhile, Thalasso is a therapy that is carried out using ingredients derived from the sea such as sea water, algae, seaweed, sand and sea mud and offers a wide range of spa treatments using technological spa equipment with excellent services. This therapy has only been found at the Grand Mirage Bali Resort since 1985 featuring an aqua medic pool with heated seaweed and sea water supported by 16 uniquely designed treatment rooms. The results also show that traditional massage is preferred by customers. Price competitiveness is one of the reasons why people choose traditional spa.  Sense of traditional massage has also been preferred by customers.

Keywords: traditional massage, aromatherapy, oil massage, hot stone massage, Bali.
KETERAMPILAN GURU DALAM MEMBUAT MEDIA PEMBELAJARAN MEMBACA PERMULAAN DI KELAS RENDAH
Authors: Najib Muhamad Ainun , Fariha Sayidatul , Pribadi Reksa Adya
Published: March 2024

Dalam dunia pembelajaran, perencanaan dan persiapan pembelajaran merupakan hal yang sangat penting, penggunaan media yang sesuai dapat mendukung tercapainya tujuan pembelajaran, sehingga diharapkan pembelajaran dapat berjalan sesuai dengan yang direncanakan. Penelitian ini dilakukan untuk mengetahui keterampilan guru dalam membuat media pembelajaran membaca permulaan di SDN Lialang kota Serang. Pendekatan yang digunakan dalam penelitian ini adalah pendekatan kualitatif deskriptif. Data penelitian ini bersumber dari hasil observasi, hasil wawancara dengan narasumber terkait dan studi dokumen. Berdasarkan hasil penelitian yang dilakukan keterampilan guru dalam pembuatan media pembelajaran membaca permulaan di SDN Lialang kota Serang mengalami peningkatan seiring dengan kendala-kendala yang dihadapi, beberapa hasil kreasi media pembelajaran terbuat dari bahan bekas pakai yang dimanfaatkan kembali menjadi media pembelajaran, seperti kartu huruf dan buku baca.
Sino-Russian cooperation on the Ice Silk Road project in the context of the Russian-Ukrainian conflict
Authors: ZHANG YIWEN
Published: March 2024

This article examines the impact of the Russian-Ukrainian conflict on Sino-Russian cooperation, analyzes the Chinese Ice Silk Road project and the development of the Russian Northern Sea Route, and based on the above analysis, predicts the further course of cooperation between China and Russia on the Ice Silk Road project. The subject of the study is the Chinese-Russian cooperation on the Ice Silk Road project in the context of the Russian-Ukrainian conflict. The object of the study is Chinese-Russian cooperation. The author examines in detail such aspects of the topic as the problems of international relations caused by the conflict between Russia and Ukraine; exchange and cooperation between China and Russia against the background of the conflict, as well as determining the trend of future cooperation between the two countries. Special attention is paid to the situation in the Chinese-Russian Ice Silk Road project against the background of the conflict, analysis and forecast of the possibility of cooperation between the two countries on this project in the future. This article uses the method of system theory, considers Sino-Russian relations as an integral part of the system of international relations, Sino-Russian cooperation on the Ice Silk Road project as a level below the level of Sino-Russian relations, and the Russian-Ukrainian conflict as a change of circumstances. The Russian-Ukrainian conflict has exacerbated the polarization of the world. The conflict between Russia and Ukraine did not have too much impact on Sino-Russian cooperation and even introduced favorable factors into Sino-Russian cooperation, the economic sphere will be the main area of cooperation between the two countries. The conflict directly deprives Russia of its Western partners in the Northern Sea Route, and also further distances China from its Western partners in the Ice Silk Road project. The development of the Russian "Northern Sea Route" urgently needs other countries to fill the gap left by Western countries. Continuing further cooperation in the Ice Silk Road project is a reasonable choice. In the next period of time, China opened a window of opportunity for in-depth cooperation with Russia on the Ice Silk Road project. In the future, China is likely to achieve cooperation with Russia, in addition to energy cooperation in the development of the Russian "Northern Sea Route", such as technical cooperation and other cooperation.
Information security in the Union State: the universal legal dimension
Authors: Duben Andrei  Kirillovich
Published: March 2024

The subject of the study forms a set of legal norms of normative legal acts of the Russian Federation, the Republic of Belarus and the interstate association of the Union State of the Russian Federation and the Republic of Belarus, international treaties(agreements) regulating public relations in the field of information security, law enforcement practice, foreign experience of legal regulation, as well as provisions theoretical interdisciplinary research in this field. The object of the study is public relations related to the legal provision of information security in the Union State. The Russian Federation and the Republic of Belarus in the context of new challenges and threats, as well as digital transformation and geopolitical changes. The analysis indicates a certain experience of scientific research in this field. At the same time, in the context of significant changes in socio-economic and foreign policy conditions, new challenges and threats, multi-vector scientific research in the information and legal sphere is necessary. The methodological basis of this study is a system of modern general scientific and private law methods. The study of the formation, development, place and role of the legal provision of information security of the Union State of the Russian Federation and the Republic of Belarus was conducted using the following general scientific methods: analysis and synthesis, abstraction and modeling, generalization, description, etc. The main conclusions of this study were the following proposals, it is necessary to develop and approve the conceptual framework for the legal provision of information security for the development of regional interstate cooperation within the framework of the Union State of the Republic of Belarus and the Russian Federation. This is important for solving the tasks of ensuring national and international information security, implementing agreements within the framework of regional interstate associations and further forming a system of universal public law mechanisms for ensuring information security. At the same time, the strategic legal acts of the Union State in the field of information security are dynamic in nature due to changes in social and political relations, including at the international level. There is a growing tendency to perceive the information space not only as an area requiring the use of exclusively protective measures of influence, but also involving active offensive measures to the extent necessary to protect national interests.
Morocco’s path to a climate-resilient energy transition: identifying emission drivers, proposing solutions, and addressing barriers
Authors: Bouramdane Ayat-Allah
Published: March 2024

Morocco is currently at a critical juncture, facing a pivotal decision regarding its future energy transition and standing at the crossroads of its energy trajectory. The dilemma lies in whether to prioritize energy efficiency (reducing energy consumption and promoting the adoption of electric vehicles) and energy sobriety (limiting the frequency of using energy-consuming equipment) or to pursue the decarbonization of the grid through enhancements in fossil and nuclear production, gradually transitioning to a 100% renewable mix. In an effort to foster a broader contemplation, this study illuminates these concepts, encompassing an analysis of the CO2 emission drivers utilizing the Kaya equation and an exploration of the challenges and opportunities associated with the net-zero challenge and a successful energy transition, including critical materials and policy landscapes. Furthermore, the study delves into Morocco’s advancements across these three pillars of the energy transition.
Patient Preferences and Their Effects on Rehabilitation Outcomes: A Secondary Analysis of a Randomized Controlled Trial
Authors: Agger Nikolaj , Bøjstrup Jim Nørgaard , Christiansen David Høyrup
Published: March 2024

OBJECTIVE: To assess the effect of aligning patients’ preferences with specific rehabilitation delivery modes on rehabilitation outcomes.

DESIGN: A secondary analysis of a randomized controlled trial.

METHODS: The study cohort comprised 208 patients referred for physiotherapy rehabilitation after nonsurgical or surgical interventions for rotator cuff injury, shoulder impingement, or acromioclavicular osteoarthritis. Participants were randomly assigned to 1 of 3 rehabilitation modalities: (1) group-based exercise, (2) individual exercise, or (3) home exercise. In this study, participants were categorized into 2 groups: “matched preference” and “unmatched preference.” The primary outcome measure was change in function, measured with the shortened Disabilities of the Arm, Shoulder and Hand (QuickDASH). Secondary outcome measures were change in pain, assessed using the Numeric Rating Scale (NRS), mental well-being measured with the World Health Organization Five Well-Being Index (WHO-5), health-related quality of life assessed using the EuroQol-5 Domain questionnaire (EQ-5D), fear avoidance assessed using the Örebro Musculoskeletal Pain Questionnaire (ÖMPQ), and overall treatment satisfaction. Outcomes were assessed at 3 and 6 months.

RESULTS: The primary outcome measure, QuickDASH, showed no significant differences between groups at either 3 months (−3.0 [−8.2 to 2.3]) or 6 months (0.5 [−5.7 to 6.7]). Additionally, no significant differences were observed in the secondary outcome measures.

CONCLUSION: Matching patients’ preferences for specific rehabilitation delivery modes did not seem to effect rehabilitation outcomes. J Orthop Sports Phys Ther 2024;54(6):408-416. Epub 26 March 2024. doi:10.2519/jospt.2024.12314
Neuropsychological Characteristics for Admitted Patients with Left Temporal Lobe Epilepsy Disorder in Saudi Arabia: Cross-sectional Study
Authors:   Department of Clinical Psychology, King Saud bin Abdulaziz University for Health Science, Saudi Arabia, A Althunayan , S Al-Arjan ,   Department of Clinical Psychology, King Saud bin Abdulaziz University for Health Science, Saudi Arabia
Published: March 2024

Background: Chronic temporal lobe epilepsy has an impact on the focal sensory systems. Because the seizures remain for a specific period of time or are extended and referred to as complex seizures that spread to different regions of the brain, the condition is referred to as a typical type of epilepsy with central seizures. Objective: The cross-sectional study aimed to determine the neuropsychological characteristics of adult patients with left temporal lobe epilepsy, who could be admitted to an epilepsy monitoring facility for EEG testing. Patients and Methods: In 2022 (during a brief period of time between 2019 and 2020), a cross-sectional review of 27 adult patients with left temporal lobe epilepsy was conducted to assess the cognitive function by using the Wechsler Adult Intelligence Scale (WAIS) in patients admitted to King Abdul- Aziz Medical City (National Guard). The data was made public by the mental health department in the King Abdul-Aziz Medical city. Results: A total of 27 right-handed Saudi patients (19 males and 8 females) over the age of 20 years, all of whom had left temporal lobe epilepsy disorder, were studied. The results of the study showed that there were no statistically significant differences between men and women in general. Except for processing speed, the female showed better than the male. This study provides a strong indicator that Saudi adult patients undergoing EEG examinations for the epilepsy monitoring unit should be admitted. Conclusion: Patients with left temporal lobe epilepsy disorder demonstrate interactions in some mental processes that have an effect on how well they perform on evaluations of intelligence such as (WAIS). The findings of this study demonstrate the requirement for further neuropsychological assessments in order to enhance the medical services offered to these patients.
Marketing of art spaces: essence, characteristics, prospects
Authors: Tazov P. Yu.
Published: March 2024

The article studies the peculiarities of promoting art spaces as significant social and cultural objects that act as a locomotive for territorial development, attracting tourists and involving the population in cultural activities. Theoretical approaches to the marketing of art objects and art industry have been analyzed. The key functions of art spaces have been studied. It is proved that art spaces marketing has a more complex structure due to the promotion object multifunctionality than art objects marketing. The author’s art space marketing communication model has been proposed. It is based on the art spaces functions for visitors, sponsors, partners, and government agencies. This model allows differentiating targeted marketing communications for each audience, based on the functions and needs of target groups and partners. Unlike art marketing, art spaces marketing implies a complex communication with target audiences, which includes historical social and cultural, territorial, tourist, socialization, and other aspects of art space. The article substantiates the position that art space cannot be only a commercial project, but due to its social and cultural aspects should perform socialization tasks for young people. Hence, there is a need for legal regulation of art spaces in the public-private partnership framework. This requirement introduces its own adjustments in the marketing communications construction.
Alcohols as substrates in transition metal-catalyzed arylation, alkylation and related reactions
Authors: Cook Adam , Newman Stephen
Published: March 2024

Alcohols are abundant and attractive feedstock molecules for organic synthesis. Many methods for their functionalization require them to first be converted into a more activated derivative, while recent years have seen a vast increase in the number of complexity-building transformations that directly harness unprotected alcohols. This review discusses how transition metal catalysis can be used towards this goal. These transformations are broadly classified into three categories. Etherifications, characterized by derivatization of the O–H bond, represent classical reactivity that has been modernized to include mild reactions conditions, diverse reaction partners, and high selectivities. Deoxygenative functionalizations, representing derivatization of the C–O bond, enable the alcohol to act as a leaving group towards the formation of new C–C bonds. Lastly, chain functionalization reactions are described, wherein the alcohol group acts as a mediator in formal C–H functionalization reactions of the alkyl backbone. Each of these three classes of transformation will be discussed in context of intermolecular alkylation, arylation, and related reactions, illustrating how catalysis can enable alcohols to be directly harnessed for organic synthesis.
Graphitic carbon nitride as a photocatalyst for decarboxylative C(sp2)-C(sp3) couplings via nickel catalysis
Authors: Lukas Florian , Findlay Michael , Fillols Méritxell , Templ Johanna , Savino Elia , Martin Benjamin , Allmendinger Simon , Furegati Markus , Noel Timothy
Published: March 2024

The development of robust and reliable methods for the construction of C(sp2)–C(sp3) bonds is vital for accessing an increased array of structurally diverse scaffolds in drug discovery and development campaigns. While significant advances towards this goal have been achieved using metallaphotoredox chemistry, many of these methods utilise photocatalysts based on precious-metals due to their efficient redox processes and tuneable properties. However, due to the cost, scarcity, and toxicity of these metals, the search for suitable replacements should be a priority. Here, we show the use of commercially available heterogeneous semiconductor graphitic carbon nitride (g-C3N4) as a photocatalyst, combined with nickel catalysis, for the cross-coupling between aryl halide and carboxylic acid coupling partners. g-C3N4 has been shown to engage in single-electron-transfer (SET) and energy-transfer (ET) processes for the formation of C–X bonds, and in this manuscript we overcome previous limitations to furnish C–C over C–O bonds using carboxylic acids. A broad scope of both aryl halides and carboxylic acids is presented, and recycling of the photocatalyst demonstrated. The mechanism of the reaction is also investigated.
Development of a novel class of CBP/EP300 bromodomain inhibitors which block TNF-α induced NFκB signaling
Authors: Gosselé Katherine , Latino Irene , Laul Eleen , Kirillova Mariia , Pascanu Vlad , Carloni Emanuele , Bedi Rajiv , Caflisch Amedeo , Gonzalez Santiago , Nevado Cristina
Published: March 2024

Tumor Necrosis Factor α (TNF-α) is an inflammatory cytokine that is a key mediator in autoimmune disorders such as Crohn’s disease and rheumatoid arthritis (RA). Targeting epigenetic regulators of cytokine transcription and signaling is a promising therapeutic approach. However, the specific mechanisms by which they contribute to the immune response are not well established yet. Here, we present a new class of selective CBP/EP300-bromodomain (BRD) inhibitors comprising a 3-methylcinnoline as acetyl-lysine mimic discovered by high-throughput docking of a fragment library. These compounds inhibit NFκB signaling in THP-1 cells, reducing TNF-α-induced cytokine expression in vitro. Furthermore, when tested in vivo, BRD inhibitors reduced the pro-inflammatory response by decreasing the secretion of IL-1β, MCP-1, IL-1α, and IL-6 from TNF-α-stimulated animals and inhibiting the migration of innate immune cells towards the draining lymph node. The results of this study confirmed CBP/EP300-BRD as valid therapeutic targets for autoimmune diseases and our inhibitors represent a promising new class of non-cytotoxic therapeutic agents for treating RA.
The importance of crime indicators in assessing the activities of the internal affairs bodies of the Russian Federation
Authors:   East Siberian Branch of the Russian State University of Justice, Malykhina T. A.
Published: March 2024

The article deals with issues related to the analysis of quantitative and qualitative indicators of crime and their role in assessing the effectiveness of the activities of the internal affairs bodies of the Russian Federation. The issues of ensuring the effectiveness of anti-crime measures are highlighted. The analysis of the state and dynamics of crime in modern Russia and its detection is given. The problematic issues of the effectiveness of the applied norms, primarily criminal legislation, and its relationship with crime indicators are considered. An assessment of the role of latent criminal in this regard is given. Quantitative indicators of crime are studied from the position of indicating the effectiveness of the application of normative legal acts directly aimed at combating crime.
Corporate standards in the activities of state corporations: theoretical and comparative legal aspects
Authors:   Irkutsk State University, Druzhinin G. V.
Published: March 2024

The problem of implementing corporate norms in the activities of state corporations is analyzed. It is noted that there are two types of state corporations: legal entities established in the organizational and legal form of state corporations, and legal entities established by the state in the organizational and legal form of business companies. It has been established that legal entities established in the organizational and legal form of a state corporation have a public legal nature. In the activities of such entities, corporate norms do not regulate intra-organizational relations, since the role of the main regulator is assigned to legal norms. It is noted that state corporations may have an extensive system of controlled legal entities, relations between which can and are regulated, among other things, by corporate norms. It is indicated that in the activities of state corporations established in the organizational and legal form of business companies, corporate norms are implemented in the regulation of intra-organizational relations.
Excess of power by a private detective or employee of a private security organization, completed with the use of weapons or special means and resulting in serious consequences: qualification issues
Authors:   Chuvash State University named after I. N. Ulyanova, Fedorova E. L.
Published: March 2024

Based on scientific material and law enforcement practice, the issues of qualification of abuse of power by a private detective or an employee of a private security organization holding a private security guard certificate in the performance of their official duties, committed with the use of weapons or special means and resulting in grave consequences, are analyzed. It is stated that quite often in practice this crime has a group nature. Suggestions are made related to editing the existing provisions of Art. 203 of the Criminal Code of the Russian Federation, as well as the addition of new provisions. In particular, it is proposed to partially specify the content of the concept of grave consequences in relation to Part 2 of Art. 203 of the Criminal Code of the Russian Federation, and also further consolidate such a qualifying feature as the commission of this crime by a group of persons and an organized group, by formulating a new part 3 of Art. 203 of the Criminal Code of the Russian Federation.
Analysis of the Significance of Key Points of Patient Interventional Psychological Care and Pain Care
Authors: Dai Xiaoping , Luo Chu , Dai Jiawei
Published: March 2024

Interventional therapy has become increasingly popular in clinical practice due to advancements in medical technology. However, patients often experience psychological and physiological pressure due to its invasive nature. The management of patient discomfort and tension is crucial to ensure effective treatment. Psychological and pain management are essential components of interventional therapy, as they significantly impact patient recovery and prognosis. This article discussed the importance of interventional psychological and pain care for patients, starting with the development and spread of interventional therapy. The significance of providing high-quality nursing services to patients and improving their quality of life was also discussed.
Analysis of Imaging Characteristics and Dynamic Changes of 3 Cases of Severe Novel Coronavirus Pneumonia in Qinghai Province
Authors: Yu Yingfang , Zhao Ruiyun , Li Changde , Ma Fuqiang , Guo Lingyun , Li Yang
Published: March 2024

Objective: To analyze the characteristics, dynamic changes, and outcomes of the first imaging manifestations of 3 patients with severe COVID-19 in our hospital. Methods: Computed tomography (CT) findings of 3 patients with severe COVID-19 who tested positive by the nucleic acid test in our hospital were selected, mainly focusing on the morphology, distribution characteristics, and dynamic changes of the first CT findings. Results: 3 patients with severe pneumonia were older, with one aged 80. The first chest CT examination for all 3 patients differed. Imaging showed a leafy distribution of consolidation, primarily affecting the lower lobes of both lungs and extending subpleurally. A grid-like pattern was observed, along with changes in the consolidation and air bronchogram. These changes had slower absorption, especially in patients with underlying diseases. Conclusion: CT manifestations of severe COVID-19 have specific characteristics and the analysis of their characteristics and dynamic changes provide valuable insights for clinical treatment.