bluuebunny/crossref_metadata_2025 huggingface dataset:
Social stigma and the quality of life among patients with schizophrenia
Authors: Anipah Anipah , Putri Dewi Eka , Basmanelly Basmanelly
Published: November 2023

Background: Schizophrenia is a mental illness or disorder experienced by most people in the world. The stigma that exists in society with mental disorders is very high, where family acceptance and family support are shown through attitudes, actions that will greatly affect the quality of life of schizophrenics.Purpose: To find out the relationship between community stigma, family acceptance and support with the quality of life of schizophrenics.Method: Using a descriptive cross-sectional correlation approach. The sample in this research is as many as 329 families at the Jambi Regional Mental Hospital polyclinic using purposive sampling technique. The questionnaire used was the Schizophrenia Quality Of Life Scale (SQOLS), The Devaluation Families Scale (DCFS), family acceptance and support. The analysis used is multiple linear regression.Results: The average age of the respondents was 35.99, ranging from 17 to 70 years. recurrence of schizophrenics 1 time per year and less than 5 years of care.Conclusion: There is a relationship between community stigma, family acceptance and support with the quality of life of schizophrenics with a p-value of 0.000 (<0.05). The dominant factor related to quality of life is family acceptance (OR = 0.534).Suggestion: It is hoped that in caring for schizophrenics the family can be involved as a caregiver as a support system.
Factors associated with breast self-examination among women of reproductive age in Lampung-Indonesia
Authors: Diastuti Sri , Aryawati Wayan , Aryastuti Nurul
Published: November 2023

Background: Breast cancer in Indonesia ranks first with 68,858 cancer cases and the second cause of cancer-related deaths with 22,430. In 2020 in Lampung Province there were 980 cases of breast lumps and 246 cases of breast cancer while in North Lampung district there were 26 cases of breast lumps and 7 cases of suspected breast cancer. The Abung Kunang Health Center had 3 cases of lumps in the breast and 2 cases of suspected breast cancer. Cancer prevention is a priority through Breast Self-Examination (BSE).Purpose: To determine the factors associated with breast self-examination (BSE) in women of productive age (WCA) at the Abung Kunang Community Health Center, North Lampung Regency in 2023.Method: Quantitative with cross sectional design. The population in this study were women of childbearing age aged 15-49 years who were at the Abung Kunang Community Health Center in North Lampung Regency in 2022 with a total of 381 samples. The sample technique used is multi-stage random sampling. Data analysis in this study used univariate, bivariate (chi-square), and multivariate (multiple logistic regression).Results: Shows that there is a relationship between knowledge (p value 0.000 and OR 3.147), attitude (p value 0.004 OR 1.900), education (p value 0.015 and OR 1.736), support from health workers (p value 0.014 and OR 1.708) and exposure to information media (p value 0.015 and OR 3.054) and there is no relationship between family support and BSE implementation in women of childbearing age. The most related factor is knowledge with (p value 0.000 and OR 2.567). It is hoped that health workers can provide implementation demonstrations and carry out community empowerment such as IT (information and technology) training.Conclusion: Factors related to the implementation of breast self-examination (BSE) in dealing with the occurrence of breast cancer, namely knowledge, attitudes, education, family support, health workers, and exposure to information media from respondents. However, from these factors the most related at the Abung Kunang Health Center in North Lampung Regency in 2023 is knowledge with OR 2.567.
Malaria situation in Lampung Pesawaran during the COVID-19 pandemic
Authors: Triwahyuni Tusy , Haryati Siti , Nusri Marwan
Published: November 2023

Background : At the time of COVID-19 was determined as a pandemic there are still many infectious diseases that have not been eliminated such as HIV / AIDS, tuberculosis, including malaria. Malaria is an infectious disease that existed long before corona virus or COVID-19 appeared in the world.  malaria itself is a parasitic infectious disease plasmodium sp transmitted through the bite of a female Anophelese sp mosquito. The current incidence of malaria cases coincides with the COVID-19 pandemic, which could potentially increase or decrease the incidence of malaria cases.Purpose: To find out the comparison of malaria cases in endemic areas before and during the COVID-19 pandemic in The Hanura Health Center of Lampung Pesawaran Regency 2019-2020.. Method: Comparative research with purposive sampling research techniques with the population of all malaria patients in Puskesmas Hanura Pesawaran Lampung Regency from September 2019 to August 2020. Analyze data using univariate and bivariate..Results : The most cases of malaria based on the age before the COVID-19 pandemic at the age of >15 years amounted to 121 patients (72,9%) and during the COVID-19 pandemic the most at the age of >15 years amounted to 25 patients (61,0%). The most cases of malaria by gender before the COVID-19 pandemic were in 102 male patients (61,4%) and based on gender during the COVID-19 pandemic the most was in men as many as 21 patients (51,2%) . Malaria cases before the COVID-19 pandemic were highest in October 2019 at 55 patients (33,1%) and during the COVID-19 pandemic the highest in March 2020 was 14 patients (34,1%).Conclusion: There is a significant comparison in malaria cases before and during the COVID-19 pandemic with a P value of 0.033.
Antiretroviral drug adherence among patients with HIV/AIDS based on socio-demographic characteristics
Authors: Simaremare Mela Liberti Octoriani , Suharmanto Suharmanto , Pramesona Bayu Anggileo , Susianti Susianti , Kurniawan Betta
Published: November 2023

Background : The government has set a target for accelerating the prevention of HIV/AIDS in Indonesia, namely zero new infections, zero people dying from HIV/AIDS, and zero stigma and discrimination. Stigma against people living with HIV has a major impact on HIV/AIDS prevention and control programs, including the quality of life for people living with HIV. Good knowledge will reduce the stigma that appears. Adherence to the use of ARV (antiretroviral) is one of the factors that can significantly extend the life expectancy of people living with HIV (people living with HIV AIDS). ARVs work against infection by slowing the reproduction of HIV in the bodyPurpose: To identify the factors that influence the adherence of people living with HIV to taking ARVs. Method: This is an observational, descriptive, and quantitative research project with a cross-sectional approach. The research will be conducted at the Sukabumi Health Center in Bandar Lampung in 2021. The population in this project is 103 HIV patients. The sampling technique used is total sampling.Results: Meanwhile, there are more PLHIV patients from urban areas than from rural areas. People living with HIV usually need ARV if the CD4 level is 350 mm3.Conclusion: The univariate variables of age group, occupation, education, gender, and origin of residence did not affect whether people living with HIV were non-adherent to treatment.
Evaluation of the application of hospital management information system using the hot-fit method
Authors: Agustin Anjlya , Hasibuan Rapotan
Published: November 2023

Background: The hospital management information system (SIMRS) is an important part of supporting health service decisions, so it is necessary to pay attention to its sustainability. SIMRS in Aek Kanopan, North Labuhanbatu found obstacles in the form of errors and delays in sending data, resulting in incomplete monthly reports.Purpose: This research is aimed at knowing the implementation and at the same time evaluating the SIMRS hospital management information system at Aek Kanopan Hospital by looking at the human, organizational and technological aspects of the net benefit (hot-fit).Method: Quantitative study with cross-sectional design, data collection was collected through interviews and questionnaires, with a sample population of 31 people, and data were analyzed univariate and multivariate with multiple linear regression tests.Results: Based on the results obtained from the characteristics of the respondents, univariate analysis and multiple regression analysis it can be concluded that the user's perception of the human aspect of the net benefit variable is said to be good, the same is true of the organizational aspect of the net benefit variable is also good, and for the perception of the technological aspect of the net benefit variable is said to be good. This research also found that human, technological and organizational variables on net benefits have a significant effect on net benefits togetherConclusion: It can be concluded that there is a good relationship between human, technology, and organization variables on net benefits
Factors related to delayed initiation of antiretroviral therapy among patients with clinically eligible HIV-infected
Authors: Purnanto Eko , Sary Lolita , Amirus Khoidar
Published: November 2023

Background: Human Immunodeficiency Virus (HIV), namely a virus that reduces the ability of the human immune system, so that sufferers are susceptible to various diseases, the wider scope of ARV administration certainly has a positive impact in reducing mortality and morbidity, improving the quality of life of patients with HIV and AIDS.Purpose: To determine the factors associated with delayed initiation of antiretroviral therapy in Human Immunodeficiency Virus patients at the VCT (Voluntary Counseling and Testing) Clinic of Pringsewu Hospital in 2022.Method: This type of quantitative research, using a cross sectional design. The population of this study were HIV positive patients at the Pringsewu Regional General Hospital Clinic, Lampung for the year 2022, namely 174 patients, using the side total technique. Univariate data analysis, bivariate with chi square and multivariate with multiple logistic regression tests.Results: The result showed that the factors associated with delayed initiation of antiretroviral therapy in Human Immunodeficiency Virus patients at the VCT Clinic at Pringsewu General Hospital in 2022 were Socioeconomic Status (p value=0.009), education level (p value=0.001, opportunistic infections (p value= 0.001), HIV/AIDS Stigma (p value=0.003), and Access (p value=0.018). The most dominant factor associated with delayed initiation of antiretroviral therapy in patients with Human Immunodeficiency Virus infection was access (95% CI, p=0.027 and OR; 3.738).Conclusion: Antiretroviral therapy (ARV) delays in PLWHA are strongly influenced by low socioeconomic status, low education level, presence of opportunistic infections, positive stigma and remote access to healthcare services.Suggestion: Management at the hospital's VCT clinic is suggested to make guidelines or standardized services, educate about the importance of ARVs, provide motivation, and carry out consistent control of ARV therapy. The management always promotes the importance of awareness and adherence in carrying out ARV therapy which will have many benefits in improving quality of life, healthy behavior, and extending life span.
The implementation of digital application in reducing Dengue Hemorrhagic Fever (DHF) infection rate from an economic loss perspective as an effort to achieve the Sustainable Development Goals
Authors: Putro Wahyu Gito , Ratnaningtyas Tri Okta , Indah Fenita Purnama Sari , Purnawan Adhy , Riski Zaki Maulana
Published: November 2023

Background: Dengue Hemorrhagic Fever (DHF) is a disease caused by the dengue virus transmitted through the Aedes aegypti mosquito and is most commonly found in tropical regions. In contemporary society, there is significant emphasis on infectious diseases. DHF is a tropical disease that falls under the third indicator of the Sustainable Development Goals (SDGs). DHF poses a significant global public health problem. Currently, its prevalence is spread across more than 100 countries worldwide. Over three decades, the severity of DHF has shown a significant increase across the Southeast Asian region. In 2021, Indonesia recorded a total of 73,518 DHF cases with 705 fatalities. In 2022, there were 143,266 reported cases resulting in 1,237 deaths. As of March 2023, there have been a total of 17,434 reported cases with 141 fatalities. These DHF case incidence figures indicate a considerable increase.Purpose: To reduce DHF cases in South Tangerang City by creating an innovative digital application which is called “Pakar” from an economic loss perspective.Method: This research adopts a mixed-method approach with exploratory research. The research begins with a qualitative phase to design the application, followed by a quantitative phase to assess the effectiveness of the developed application. The study commences with a Focus Group Discussion (FGD) involving various stakeholders, including the South Tangerang City Health Office, public health centers, and community health workers. Subsequently, the application is developed and tested in selected pilot areas as an initial project. Further testing is conducted using a one-group pre-test post-test design. The experimental procedure includes a pre-test as an initial observation, followed by the intervention, and concludes with a post-test as a final observation.Results: During the pre-test, it was observed that DHF patients had a moderate level of knowledge, with a cumulative percentage of 46%. In contrast, the majority of respondents in the post-test had a high level of knowledge regarding DHF diagnosis, with a percentage of 76%. The paired t-test showed a t-value of -6.306 and the corresponding probability or significance value of 0.000 (p < 0.005).Conclusion: The expert system application, as an innovative approach for DHF mitigation and the experimental assessment of economic impact, is effective as indicated by the pre-post test. Furthermore, it is crucial to consider the economic impact of the costs incurred by DHF patients by placing greater emphasis on improving environmental cleanliness efforts.
Sports massage therapy on the reduction of delayed onset muscle soreness: A systematic review and meta analysis
Authors: Yanitamara Dhiva Luhtirani , Perdana Suryo Saputra , Azizah Amalia Nur
Published: November 2023

Background: DOMS (Delayed Onset Muscle Soreness) is a condition where muscle pain appears shortly after activity, usually occurring shortly after doing sports or activities that exceed the usual capacity. It can also be caused by doing sports or activities he has never done before. DOMS usually appears in a healthy person but mainly occurs in athletes. A sports massage intervention is recommended to reduce the DOMS in the recovery process.Purpose: To determine whether sports massage can reduce DOMS and provide recovery effects on a person.Method: This research is a systematic review and meta-analysis using the PRISMA diagram. Performed article search with eligibility test with PICO. Population: people with DOMS. Intervention: Sport massage. Comparison: control treatment. Outcome: pain reduction. The articles used came from 2 databases, namely PubMed and Science Direct. The keywords in this article search are "DOMS," AND "Recovery," AND "Sport massage." The inclusion criteria in this study were full-text articles with a Randomized Control Trial research design. The relationship measure used is Mean SD. This article was analyzed using the Review Manager 5.4 application.Results: The eight articles reviewed were from California, Canada, Spain, the USA, South Africa, and Brazil. The results showed that sports massage could not reduce DOMS effectively and significantly. A person with DOMS who received sports massage had an average pain score of -0.19, lower than someone who received control treatment (SMD= -0.19; 95% CI= -1.93 to 0.10; p=0.19).Conclusion: Sports massage cannot reduce DOMS in the recovery process effectively and significantly.
Health, environment, current knowledge of the heads of household and acute respiratory infection in toddlers
Authors: Bedho Martina , Rif'atunnisa Rif'atunnisa , Owa Khrispina , Patmawati Try Ayu
Published: November 2023

Background: The ten patrons of disease at the Moni Health Center, the highest acute respiratory infection (ARI) of all cases, the second highest ARI in toddlers (62.90%) in Ende District. ARI can inhibit oxygenation of the body, causing decreased cell metabolism, thereby inhibiting growth and development, can contribute to morbidity and mortality in infants. Toddlers are still fully cared for by the family, which is the front line to prevent toddlers from getting sick.Purpose: Determine the effect of knowledge and family home environment on the incidence of respiratory infections in toddlers.Method: The research design is a mix of methods and approaches cross sectional. The sample size was calculated based on the Slovin formula of 164 respondents. Sampling using purposive dan accidental sampling. Data collected by interview, observation. The instrument used is the standard instrument. Bivariate Analysis Who Square to examine the effect of family tasks on the incidence of ARI. Logistic regression test to analyze the strength of the influence of knowledge and family home environment on the incidence of ARI at the 95% confidence level and significance limit p ≤0,05.Results: Bivariate test increases the risk, namely family knowledge OR=1.950 (95% CI: 1.571-2.421; p=0.000), maintenance of the home environment, OR = 94.53 (95%) CI: 4.120 - 21.690p - value = 0.000 ), In the multivariate analysis, it was found that the most dominant variable influencing increased risk was the maintenance of the home environment. There is a need for periodic health counseling and promotion related to efforts to prevent and control ARI, further research needs to use other methods.Conclusion: The most dominant variable that influences increasing risk is the maintenance of the home environment.  There is a need for periodic health counseling and promotion related to efforts to prevent and control respiratory  infections, further research needs to use other methods.
Hepatocellular Carcinoma's Characteristics in an Endemic Country: A Closer Examination of Tumor Grade and Microvascular Invasion
Authors: Retnowulan Ignasia Andhini , Stephanie Marini , Rahadiani Nur , Syaiful Ridho Ardhi , Krisnuhoni Ening
Published: November 2023

Objective: Although histological grade and microvascular invasion are known predictors for patient survival and recurrence in hepatocellular carcinoma (HCC), their relationship with various clinical and histomorphological features of HCC remains unclear.
Materials and Methods: Medical records were retrieved from 61 patients who were diagnosed with HCC from 2008-2018. Clinical and histomorphological variables that were hypothesized to be associated with histological grade and microvascular invasion were analyzed statistically using the Chi-square test or the Fisher’s exact test as alternatives. Multivariate analysis was performed with logistic regression model.
Results: The majority of the patients had well to moderately-differentiated HCC (67.2%) with some of them presenting microvascular invasion (57.4%). Alpha-fetoprotein level (AFP) ≥100 ng/ml (p=0.036), tumor size >7cm (p=0.031) and mitotic index ≥5 per 10 high power field (p=0.009) were significantly correlated with poorly-differentiated HCC. Mitotic Index ≥5 per 10 high power field was an independent factor for poorly differentiated HCC. Meanwhile BCLC stage B and mitotic index were also an independent factor for the presence of microvascular invasion.
Conclusion: Larger tumor size and higher mitotic index was significantly correlated and independent factors for poorly differentiated HCC and microvascular invasion. In biopsy specimens for which the microvascular invasion is difficult to assess, histological grade, tumor size and mitotic index may be beneficial to depict the prognosis of patients with HCC.
The Impact of Retro-apical Urethral Dissection Approach Technique on Positive Surgical Margins in Robotic-assisted Laparoscopic Radical Prostatectomy: A Study in Thailand
Authors: Mahamongkol Katunyou , Hajidae Malik , Aussavavirojekul Pubordee , Hansomwong Thitipat , Srinualnad Sittiporn
Published: November 2023

Objective: Among the various postoperative outcomes following robotic-assisted laparoscopic radical prostatectomy (RARP), positive surgical margins (PSMs) are a significant prognostic factor associated with biochemical recurrence (BCR). Many surgical techniques are available for RARP; however, the technique proposed in this study may improve surgical outcomes. This study aims to evaluate the incidence of post-operative PSMs in patients diagnosed with clinically localized prostate cancer at Siriraj Hospital using the retro-apical urethral dissection approach with a 30-degree-lens flip-up technique.
Materials and Methods: A retrospective review of 2,114 consecutive patients who underwent RARP with the conventional technique was conducted using Siriraj Hospital’s database, from January 2007 to June 2022. Propensity score matching was employed to select a group of 284 men from the total cohort of 2,114 patients who underwent conventional radical prostatectomy (Group 1) for comparison against another group of 284 patients who underwent the retro-apical dissection technique (Group 2). The incidence of PSMs was then evaluated in each group.
Results: Of the 568 patients, PSMs were observed in 219 patients. The overall incidence of PSMs decreased from 128 cases (45.1%) in Group 1 to 91 cases (32.0%) in Group 2 (p-value <0.01). Similar results were seen in the subgroup of patients with pT2 staging who had PSMs (52 cases vs 24 cases, p-value <0.01). PSMs occurred mostly at the apex with a total of 112 cases (52.1%).
Conclusion: The retro-apical urethral dissection approach with a 30-degree-lens flip-up technique is associated with a lower risk of overall PSMs and the trend of apical PSMs, indicating its clinical significance.
Court-Type Thai Traditional Massage for Patients with Intractable Peripheral Neuropathic Pain: a Randomized Controlled Trial
Authors: Apichartvorakit Angkana , Euasobhon Pramote , Booranasubkajorn Suksalin , Suwannatrai Supakij , Vannabhum Manmas , Rattanawongsamathakul Darunee , Prasartpornsirichoke Sawita , Akarasereenont Pravit , Asavamongkolkul Apichat
Published: November 2023

Objective: Neuropathic pain management involves both pharmacological and non-pharmacological interventions. Despite this, no prior research has demonstrated the efficacy of court-type Thai traditional massage (CTTM) for neuropathic pain relief. This study aimed to investigate the potential benefits of CTTM in alleviating neuropathic pain.
Materials and Methods: A preliminary single-blind randomized controlled trial was conducted on 28 participants with peripheral neuropathic pain, who were equally assigned to 2 groups. Both groups received standard drug treatment; however, the intervention group additionally received CTTM and hot herbal compression, while the active control group only received HHC. The adjuvant treatments were administered twice weekly for 4 weeks (V1-V8). A follow-up was conducted 4 weeks posttreatment (V9). Outcome measures were assessed at V1, V4, V8, and V9 using a numerical rating scale and the Thai versions of the Neuropathic Pain Symptom Inventory, the Brief Pain Inventory, and the EQ‑5D‑5L health questionnaire.
Results: The data revealed that the intervention and active control groups had statistically significant differences in their pain intensity scores (P < 0.001), total neuropathic pain intensity scores (P = 0.001), and utility of health scores (P = 0.007) during the follow-up period. When comparing outcomes between V1 and V8, the groups exhibited significant differences in pain reduction (P = 0.003) and quality of life (P = 0.027).
Conclusion: This study provides initial evidence supporting the potential benefits of CTTM in alleviating peripheral neuropathic pain and improving quality of life. Future research should further investigate the application of CTTM in managing peripheral neuropathic pain conditions.
Зміни показників оксидативного стресу при місцевому застосуванні міноксидилу в щурів з хімічною депіляцією
Authors: Балюк О. Є. , Важнича О. М. , Луценко Р. В. , Костенко В. О. , Акімов О. Є.
Published: November 2023

Захворювання або втрата волосся можуть суттєво впливати на добробут і якість життя. Відомо багато видів алопеції, але в кожному випадку патогенетична терапія спрямована на стимулювання анагену, затримку катагену, відновлення або підтримку належної густоти волосся. Міноксидил для місцевого застосування є одним з найвизнаніших засобів лікування алопеції, але його вплив на рівень оксидативного стресу під час терапії описано недостатньо.Мета дослідження – вивчити вплив місцевого застосування міноксидилу на показники оксидативного стресу під час регенерації волосся в тварин з хімічною депіляцією.Експерименти були виконані на 35 білих щурах-самцях. Патологію моделювали шляхом хімічної депіляції шкіри спини щурів площею 8 см × 4 см калію тіогліколатом. Лікування розпочинали відразу після депіляції, наносячи на шкіру депільованої ділянки 2 % розчин міноксидилу 1 раз на добу в дозі 30 мг/кг. Через 3 дні, 9 днів та 21 день після депіляції тварин виводили з експерименту шляхом термінальної крововтрати. Відростання волосся оцінювали в балах. У крові та гомогенаті шкіри визначали малоновий діальдегід (МДА) і 4-гідроксиалкеналі як продукти пероксидного окиснення ліпідів (ПОЛ), активність супероксиддисмутази (СОД) і каталази. Одержаний цифровий матеріал статистично обробляли шляхом однофакторного дисперсійного аналізу ANOVA з апостеріорним Тьюкі-тестом або за критерієм U Манна-Уітні.При лікуванні міноксидилом через 3 дні стан шерсті досліджуваної ділянки був таким самим, як при контрольній патології. Через 9 днів препарат сприяв тенденції до появи шерстного покриву з оцінкою 3 бали. Через 21 день у групі з експериментальною терапією переважав розвиток волосся в 4 бали (повна нормалізація), але різниця з контрольною патологією була не вірогідною. Відновлення після хімічної епіляції без лікування супроводжувалось накопиченням МДА, зниженням активності СОД та коливаннями активності каталази в шкірі ураженої ділянки та крові. Під дією міноксидилу в усі строки спостережень у шкірі відмічалось зниження вмісту МДА, підвищення активності СОД та зміни активності каталази, яка додатково зростала через 3 дні, нормалізувалась через 9 днів і була на рівні контрольної патології через 21 день. Поряд з цим, препарат призводив до зменшення накопичення продуктів ПОЛ та суттєвого збільшення активності СОД у крові порівняно з контрольною патологією, що за спрямуванням було подібне процесам у шкірі. Під впливом міноксидилу каталазна активність крові зростала в усі терміни спостережень.Отже, міноксидил за умов щоденного місцевого лікування втрати волосся демонстрував антиоксидантну дію в шкірі ураженої ділянки та крові. Виявлена особливість фармакодинаміки препарату може бути корисна за його клінічного застосування на тлі оксидативного стресу, викликаного старінням, хіміо- або радіотерапією.
Аналіз ліпофільного екстракту плодів коріандру (Coriandrum sativum L.) методом газової хроматографії з мас-детекцією
Authors: Гойстер О. С. , Гудзенко А. В. , Курапова Т. М. , Бутко Л. А. , Шураєва Т. К. , Середа П. І. , Марунич Р. Ю. , Делян Є. П.
Published: November 2023

Перспективним напрямом удосконалення процедури стандартизації багатокомпонентних фітозасобів є використання так званих маркерних сполук, або маркерів – речовин, присутність яких характерна лише для окремої лікарської сировини. Впровадження методик якісного та кількісного аналізу, які засновані на використанні маркерів, має не лише велике практичне значення, але й суттєву наукову доцільність.Одними з найпоширеніших складових, що застосовуються для виготовлення комплексних фітопрепаратів, є плоди коріандру, що успішно використовуються в медичній практиці як у вигляді монопрепаратів, так і у вигляді складових частин багатокомпонентних лікарських засобів рослинного походження.Фармакологічна активність плодів коріандру зумовлена наявністю в їхньому складі комплексу біологічно активних речовин, зокрема терпеноїдів, з вмістом яких пов’язані такі фармакологічні властивості рослини, як бактерицидна, протизапальна тощо. Тому вважали за доцільне провести пошук маркерів для стандартизації рослини в сумішах саме серед даної групи біологічно активних речовин.

Мета дослідження – провести аналіз ліпофільного екстракту плодів коріандру зі застосуванням методу газової хроматографії з мас-детекцією для пошуку речовин-маркерів для стандартизації рослини в сумішах.Об’єктом дослідження були плоди коріандру в пачках з внутрішнім пакетом по 100 г (виробник ЗАТ «Ліктрави», м. Житомир, Україна, серія 010414). Ліпофільний екстракт досліджуваної сировини отримували шляхом перегонки сировини з водяною парою. Дослідження летких компонентів здійснювали за допомогою методу газової хроматографії з масдетекцією. Хроматографічне вивчення досліджуваних екстрактів проводили на газовому хроматографі Agilent 6890, обладнаному масспектрометричним детектором (модель 5973). Ідентифікацію досліджуваних компонентів виконували за масспектрами та часом утримування компонентів.У результаті проведеного аналізу в досліджуваному екстракті було ідентифіковано 22 летких компоненти. Мажоритарним компонентом ліпофільного екстракту є терпеноїд ліналоол, вміст якого серед летких сполук складає 85,812 % ± 9,611 %. Значно меншим вмістом характеризуються наступні леткі компоненти: камфора (5,021% ± 0,422 %), гераніол (5,155 % ± 0,624 %) і гераніл ацетат (1,356 % ± 0,142 %). Вміст інших індивідуальних летких компонентів був менший ніж 1 % від маси всіх летких компонентів досліджуваного екстракту.Виходячи з отриманих даних, пошук маркерів для стандартизації плодів коріандру в рослинних сумішах доцільно проводити серед наступних мажоритарних компонентів ліпофільного екстракту рослини, таких як ліналоол, камфора, гераніол, та гераніл ацетат.
Stability of Covid-19 Dynamics: A Case Study of Nigeria
Authors: Sunday Nwokpoku Aloke  , Emmanuel Nwaeze  , Louis Omenyi
Published: November 2023

In this paper, a SEIR epidemic model is considered; where individuals in the population are assigned to different compartments of SEIR defined with respect to epidemic status of Covid-19 in Nigeria. The article has demonstrated a simple mathematical model for the transmission of Covid-19 disease taking into account loss of human immunity with the aim that this model proves useful in controlling the possibility of a person contracting Covid-19 twice. When the basic reproduction number   means that the Covid-19 free equilibrium solution is locally asymptotically stable. This suggests that the number of new cases of the disease will decrease over time and eventually will vanish as that whcih causes   are established. The basic reproduction number and the model analysis (local stability of disease-free equilibrium and disease-endemic equilibrium) of the system were calculated and the stability of the SEIR model was checked.
Notes & News Vol. 46(1)
Authors: Hoque Settings Seikh Azimul
Published: November 2023

Abstract not available
BANGLADESH J CHILD HEALTH 2022; VOL 46 (1) : 44-45
Effects of Carbamazepine and Sodium Valproate on Serum Cholesterol in Epileptic Patients
Authors: Mosharraf Hossain Mohammed Khaled , Sultana Nasima , Rahman Hafizur , Nurul Alam Mohammad , Rahman Md Moshiur , Munira Begum Noor e Nazar Mst
Published: November 2023

Introduction: Epilepsy is a common, chronic and non-communicable disorder of the brain. Carbamazepine, increasing serum cholesterol level, causes adverse cardiovascular and cerebrovascular events. Sodium valproate causes weight gain, hyperinsulinemia and insulin resistance leading to metabolic syndrome. These all causes increased morbidity and mortality of epileptic patients in later life.
Objective: to find out the effects of carbamazepine and sodium valproate on serum cholesterol in epileptic patients.
Materials and Methods: This cross-sectional study was conducted in the Department of Biochemistry, Dhaka Medical College during the period of July 2017 to June 2018. A total of sixty diagnosed epileptic patients were selected, of them, thirty patients were taking carbamazepine and thirty on sodium valproate. Data were analyzed with the help of SPSS version 22.0. Unpaired Student’s t-test and Mann-Whitney U test were done to see the level of significance (p<0.05). For correlation, Pearson’s correlation coefficient test was done.
Result: Mean ± SD of serum total cholesterol in carbamazepine and sodium valproate patients were 218.73 ± 29.70 mg/dl and 190.14 ± 17.10 mg/dl respectively (p<0.001).
Conclusion: This study reveals that hypercholesterolemia is related to carbamazepine medications.    
Medicine Today 2023 Vol.35(2): 83-86
Disease Characteristics of Chronic Venous Disease in Referral Hospital in Bangladesh
Authors: Shamim Reza Md , Nazmus Sabah Md , Yasmin Mst Tanzila , Zahan Most Nusrat , Muhammad Bashar Abul Hasan , Islam Md Moynul , Rahman Md Mokhlesur , Ghose Shantonu Kumar
Published: November 2023

Introduction:Chronic venous disease (CVD) is widespread, underdiagnosed, and can progress to chronic venous insufficiency and venous ulcer, which can require extensive treatment. This condition negatively impacts patient quality of life and place substantial burdens on healthcare resources. In Bangladesh this problem is increasing with very poor awareness.
Materials and Methods: The prospective observational study was carried out in department of vascular surgery of National Institute of Cardiovascular disease. We randomly choose 180 patients with chonic venous disease (CVD) and evaluate their characteristics and prevalence of several types. Data collection started from May 2021 for next 6 months.
Results: : The patients of this survey were aged between 24 to 70 years and the Mean±SD age was 43.6±12.2. 78.3% of total study population were male, 33.3% were businessman and 10% were housewife. 66.6% patients were having low socio-economic condition. C2 varicose veins were highly prevalent among the study population (35%) & lowest prevalence of C4b lipodermatosclerosis or atrophie blanche (11.7%) we have seen in the study. (31- 40) & (51-60) these two age group were more prone to have CVD, 28.33% (n51) & 26.67% (n48) (p <0.001*) respectively. Male were predominantly more prevalent to having CVD, 78.33% (n141), (p <0.001).
Conclusion: Patients having CVD, invariably presented with the complains of heaviness of leg and unexplained leg swelling and Varicose vein were highly prevalent irrespective of sex. Advanced stages are more common in male patients. In every age group were having different stages of CVD. More awareness can help patients to get proper management and relief from chronic venous disease.
Medicine Today 2023 Vol.35(2): 105-108
O uso de prebióticos e probióticos na prevenção e tratamento do câncer de colorretal
Authors: Santos Renata Lopes Ruiz dos , Bueno Isabelli Gonçalves , Oroscink Nicole Valentine Foltram , Pereira Gustavo José Vasco
Published: November 2023

O propósito deste estudo foi conduzir uma revisão bibliográfica sobre a utilização de prebióticos e probióticos como complemento ao tratamento medicamentoso do câncer colorretal, com o intuito de promover a atividade das bactérias benéficas visando à restauração da função saudável da microbiota intestinal. A metodologia empregada na pesquisa foi uma revisão bibliográfica narrativa com o objetivo de encontrar estudos, resultados e comprovação do potencial terapêutico na utilização de prebiótico e probióticos na ajuda e no tratamento deste câncer. Os resultados que obtivemos foi que esta utilização ajuda a microbiota intestinal, fazendo com que existam mais bactérias benéficas, que ajudam na digestão, na diminuição dos pólipos intestinais o que leva ao equilíbrio e ao bom funcionamento intestinal. Conlui-se que foi possível observar que a utilização de probióticos e prebióticos têm ação benéfica para a prevenção e o tratamento do câncer do colorretal, pois colaboram para a manutenção da microbiota intestinal, suprimindo o caráter mutagênico, evitando assim uma disbiose e o possível início de um processo de carcinogênese.
Trajetórias de mães de bebês prematuros: Revisão integrativa das vivências no cenário da COVID-19
Authors: Ferronato Gabriela Clivatti , Pelizzoni Aline Vaneli
Published: November 2023

A pandemia ocasionada pelo vírus COVID-19, teve implicações na saúde de gestantes e no nascimento prematuro dos seus bebês. A fim de investigar a vivência dessa população, este trabalho tem por proposição produzir uma Revisão Integrativa. Os resultados e discussões apresentados se referem ao recorte de uma pesquisa maior em desenvolvimento. Para isso, as buscas foram sistematizadas e realizadas nas bases de dados sciELO (Scientific Electronic Library Online), Periódicos CAPES e Biblioteca da Saúde (BVS), com os descritos: ‘prematuridade’, ‘covid-19’, ‘gestação’, ‘uti neonatal’. Os critérios de inclusão foram artigos disponíveis na íntegra, em português e inglês, publicados a partir do ano de 2020, de acesso gratuito e que tivessem afinidade com a temática. Foram incluídos, inicialmente, 3 artigos, que tratam sobre as possíveis complicações na gestação em decorrência da doença, uma revisão da literatura sobre os conhecimentos atuais da COVID-19 no período gestacional e as vivências de mães de lactentes que nasceram prematuros, durante a pandemia. Os resultados denotam impactos causados pela pandemia na vivência da prematuridade, tendo pontos de distinção e similaridade com o que é experienciado fora deste cenário, bem como, revelam uma lacuna no conhecimento quanto a pesquisas qualitativas sobre a vivência subjetiva desta população com o nascimento prematuro na condição de contaminação pelo vírus.
Evaluation of the role of vitamin D in patients with psoriasis
Authors: Pedon Isabel Caroline Zanatta , Fim Gabriela Martins , Libera Nathalia Kaminski Della , Mattos Alexandra Brugnera Nunes de
Published: November 2023

Objectives: Investigate whether there is any association between the levels of vitamin D in the blood and the seriousness of psoriasis or its development. Methods: The study is characterized as observational, retrospective, composed of 40 patients with psoriasis who had serum vitamin D levels, who underwent clinical care at a dermatology outpatient clinic in Passo Fundo/RS, from August 2019 to June 2021.  Results: Of the 40 interviewees, 60% were female and 40% male. Phototypes II and III prevailed. Regarding family health history, 50% had a history of the disease. Regarding the duration of psoriasis, the predominant group was between 1-10 years (57.5%). The most prevalent psoriasis subtype was vulgaris (62.5%). Regarding serum vitamin D results, the lowest index was 15.2 ng ̸ mL, the highest was 42.3 ng ̸ mL and the average was 25.99 ng ̸mL. In the predominant age group, between 20-40 years, the proportion of patients with vitamin D was less than 30 ng ̸mL is 83.33%. The lower the phototype, the greater the proportion of patients with suboptimal serum vitamin D. In the group of patients with disease duration > 10 years, vitamin D levels were lower. There is no extreme difference in the effectiveness of treatments when analyzing the average, minimum and maximum serum levels of vitamin D. Conclusion: There was no relationship between serum levels of 25-hydroxyvitamin D (25OHD) and the development of psoriasis or even control – worsening of the clinical picture of disease.
Avaliação e comparação da eficácia e segurança de diferentes técnicas de rejuvenescimento facial
Authors: Morais Kelly Cíntia Rufino de , Melo Carla Mickaelly Soares
Published: November 2023

O estudo revisou as técnicas mais comuns na odontologia, incluindo fios de sustentação para realização de lifting facial, fibrina rica em plaquetas injetável (I-PRF), ácido hialurônico, toxina botulínica e microagulhamento. O objetivo desta pesquisa foi apresentar e comparar as principais técnicas de rejuvenescimento facial existentes no mercado. A metodologia utilizada neste estudo foi de cunho qualitativo com elaboração de revisão narrativa bibliográfica nas bases de dados LILACSM SciELO e MEDLINE relevantes para o tema proposto. Para a avaliação da eficácia, considerou-se parâmetros como redução de rugas, melhora da textura da pele, enquanto a segurança foi avaliada com base em efeitos colaterais e o tempo de recuperação. Os resultados mostraram que todas as técnicas apresentaram eficácia no rejuvenescimento facial, mas os resultados variaram de acordo com a técnica utilizada e as necessidades dos pacientes. No geral, o estudo concluiu que a escolha da técnica de rejuvenescimento facial deve ser baseada nas necessidades individuais do paciente e nas habilidades e experiência do profissional que realiza o procedimento.
Epidemias de HIV e COVID-19: A coexistência viral tem impacto no curso das entidades clínicas? Uma revisão narrativa de literatura
Authors: Silva Neto Guido Finamor da , Villas Boas Gabriel Di Lorenzo , Andrade Marileia Chaves
Published: November 2023

Introdução: A sindemia é caracterizada como a situação em que duas ou mais doenças interagem de tal forma que causam danos maiores do que a mera soma das duas doenças. Nesse sentido, os casos de coinfecção entre o SARS-CoV-2 e o HIV podem ser interpretados dessa forma. Objetivo: O presente estudo teve como objetivo compreender a coexistência viral do SARS-CoV-2 com o HIV e detalhar quais as consequências da sobreposição desses dois vírus no curso das entidades clínicas dos pacientes com essa coinfecção. Materiais e Métodos: Trata-se de uma revisão integrativa de literatura acerca das características clínicas gerais sobre a coinfecção pelo SARS-CoV-2 em pacientes com HIV. Utilizou-se a estratégia PICO para a elaboração da pergunta norteadora. Ademais, realizou-se o cruzamento dos descritores “HIV”; “COVID-19”; “Coinfecção”, nas bases de dados National Library of Medicine (PubMed MEDLINE), Scientific Eletronic Library Online (SCIELO), Ebscohost, Google Scholar e Biblioteca Virtual de Saúde (BVS). Resultados e Discussão: Os estudos mostram que a coinfecção pelo SARS-CoV-2 envolve nuances específicas dentro da análise médica, perpassando por interações entre as terapias antirretrovirais e a resposta imunológica, por desafios no que tange o diagnóstico e o tratamento, e até mesmo pelas suas implicações na saúde pública. Conclusão: Tanto a COVID-19, quanto o HIV/AIDS são problemas de saúde gravíssimos que a humanidade enfrenta há algum tempo. A situação é ainda pior quando pacientes com HIV contraem o vírus respiratório, sendo necessário mobilizar rapidamente recursos para o combate simultâneo das doenças.
Análise da mortalidade infantil por causas evitáveis no Paraná, 2010-2020
Authors: Ceron Beatriz , Silva Júlia Fernandes , Santos Mariana Carvalho dos , Haidar Sara Reda , Lorencete Taisa Valques , Silva Rosemarie Dias Fernandes da
Published: November 2023

A taxa de mortalidade infantil reflete múltiplos aspectos da saúde de uma população, assim este estudo objetivou analisar a mortalidade infantil, seguindo critérios de evitabilidade, no estado do Paraná no período de 2010 a 2020. Tratou-se de um estudo descritivo de abordagem quantitativa com base nos dados secundários do Sistema de Informações sobre Mortalidade e do Sistema de Informações sobre Nascidos Vivos, disponíveis no Departamento de Informática do Sistema Único de Saúde. Foram utilizadas as seguintes variáveis: número e percentual de óbitos infantis em menores de 5 anos por causas evitáveis, causas mal definidas e não claramente evitáveis; faixa etária, raça/cor e sexo. Os dados foram coletados, analisados e tabulados em planilhas eletrônicas Microsoft Office Excel. No período e local estudado, foram registrados 21.442 óbitos, 63% decorreram de causas evitáveis, principalmente, da atenção ineficaz à gestante e ao recém-nascido, em sua brancos e do sexo masculino. 45,8% das crianças morreram na primeira semana de vida. Esse cenário de evitabilidade dos óbitos demonstra a necessidade do fortalecimento de Políticas Públicas voltadas à assistência à saúde do binômio mãe filho, assim como a melhoria de acesso aos serviços de saúde e a intersetorialidade como fator imprescindível na redução das iniquidades em saúde.
Uso da radiofrequência no tratamento de fibro edema gelóide grau III em glúteo: Uma revisão literária
Authors: Vargas Brenda Kauanne Rodrigues , Barros Kananda Morais , Gomes Andressa de Oliveira
Published: November 2023

A pele, sendo o maior órgão do corpo humano, desempenha um papel crucial tanto na proteção quanto na estética. O fibro edema gelóide (FEG), vulgarmente conhecido como celulite, é uma disfunção estética categorizada em quatro graus que pode afetar a integridade da pele. A radiofrequência é uma modalidade terapêutica de fisioterapia dermatofuncional que utiliza um aparelho de corrente de alta frequência para gerar calor por conversão em tecidos corporais humanos. Este estudo tem como objetivo avaliar a eficácia da radiofrequência na melhoria do fibro edema gelóide grau III na região dos glúteos. Se configura como uma revisão sistemática da literatura que teve como objetivo uma pesquisa abrangente de artigos científicos realizados por meio de fontes eletrônicas, incluindo Google Acadêmico, SCIELO (Biblioteca Eletrônica Científica Online), BVS (Biblioteca Virtual em Saúde) e PUBMED. O período de pesquisa abrange os anos de 2010 a 2023. E espera-se que, ao final, sejam observadas melhorias significativas no fibro edema gelóide grau III em pacientes submetidos à técnica de radiofrequência. A aplicação deste tratamento visa alcançar resultados superiores na redução da celulite e na melhoria da aparência da pele, contribuindo assim para a promoção da saúde e bem-estar dos participantes.
Números de casos e perfil epidemiológico da sífilis congênita na Décima Regional de Saúde do Paraná
Authors: Ferrari Gabriel Hayashi , Mombelli Daniel Mainar , Castro Eloisa Carvalho de , Castro Karoline Novaes de , Silva Marianne Fávaro Calixto da , Griep Rubens
Published: November 2023

Objetivo: Traçar o perfil epidemiológico de sífilis congênita na Décima Regional de Saúde do Estado do Paraná. Métodos: O estudo foi realizado entre Janeiro de 2012 a Dezembro de 2021, incluindo 25 municípios e dados secundários coletados através do sistema de informação de agravos de notificação, SINAN, o qual compõe a plataforma DataSus/TabNet. Foram observados cerca de 200 casos diagnosticados de sífilis congênita durante esse período, no qual 4 casos foram dados como natimorto/aborto e 24 casos foram descartados como sífilis, posteriormente. Diante disso, notou-se que 2018 foi o ano que mais apresentou diagnósticos da doença, sendo Cascavel a cidade de maior casos notificados e Vera Cruz do Oeste a municipalidade com maior taxa de incidência (11,89 casos/1000 nascidos vivos). Além disso, identificou-se um predomínio em gestantes de raça branca, com faixa etária de 20-24 anos de idade e Ensino Médio Incompleto, no qual a maioria realizaram o pré-natal e teve seu diagnóstico durante este mesmo período, ademais, grande parte de seus parceiros não prosseguiram com tratamento adequado. Então, este estudo contribuiu para uma compreensão mais abrangente do perfil epidemiológico da sífilis congênita no Paraná, evidenciando áreas de apreensão e provendo dados imprescindíveis que embasam a concepção de políticas de saúde efetivas, voltadas para a redução dos efeitos adversos dessa doença debilitante sobre a coletividade.