bluuebunny/crossref_metadata_2025 huggingface dataset:
Postoperative Rehabilitation using Digital Healthcare System in Patients with Rotator Cuff Repair: A Randomized Controlled Trial
Authors: Lim Jae-Young , Shim Ga Yang , Kim Eun Hye , Baek Yoon Jeong , Chang Won Kee , Kim Bo Ram , Oh Joo Han , Lee Jong In , Hwang Ji Hye
Published: September 2022

A digital healthcare system based on augmented reality (AR) has promising uses for postoperative rehabilitation. We compared effectiveness of AR-based and conventional rehabilitation in patients after rotator cuff repair (RCR). This study randomly allocated 115 participants who underwent RCR to digital healthcare rehabilitation group (DR group) and conventional rehabilitation group (CR group). The DR group performed AR-based home exercises using UINCARE Home+, whereas the CR group performed brochure-based home exercises. The primary outcome was a change in the Simple Shoulder Test (SST) score between baseline and 12 weeks postoperatively. The secondary outcomes were the Disabilities of the Arm, Shoulder and Hand (DASH) score; Shoulder Pain And Disability Index (SPADI) score; EuroQoL 5-Dimension 5-Level (EQ5D5L) questionnaire score; pain; range of motion (ROM); muscle strength; and handgrip strength. The outcomes were measured at baseline, and at 6, 12, and 24 weeks postoperatively. The change in SST score between baseline and 12 weeks postoperatively was significantly greater in the DR group than in the CR group (p = 0.025). The SPADI, DASH, and EQ5D5L scores demonstrated group \(\times\) time interactions (p = 0.001, = 0.04, and = 0.016, respectively). However, no significant differences over time were observed between the groups in terms of pain, ROM, muscle strength, and handgrip strength. The outcomes showed significant improvement in both groups (all p < 0.001). No adverse events were reported during the interventions. AR-based rehabilitation significantly improved shoulder function after RCR compared to conventional rehabilitation. Therefore, as an alternative to the conventional rehabilitation, the digital healthcare system is effective for postoperative rehabilitation. Trial registration: ClinicalTrials.gov (identifier: NCT04511377). Registered on August 10, 2020. http://clinicaltrials.gov/ct2/show/NCT04511377
The role of internal variability in global climate projections of extreme events
Authors: Blanusa Mackenzie L. , López-Zurita Carla J. , Rasp Stephan
Published: September 2022

Climate projection uncertainty can be partitioned into model uncertainty, scenario uncertainty and internal variability. Here, we investigate the different sources of uncertainty in the projected frequencies of daily maximum temperature and precipitation extremes, which are defined as events that exceed the 99.97th percentile. This is done globally using initial-condition large ensembles. For maximum temperature extremes, internal variability dominates in the next two decades. Around the middle of the 21st century model and scenario uncertainty become the dominant contribution in the tropics but internal variability remains dominant in the extra-tropics. Towards the end of the century, model and scenario uncertainty increase to near equal contributions of ∼40% each globally with large regional fluctuations. For precipitation extremes, internal variability dominates throughout the 21st century, except for some tropical regions, for example, West Africa. In regions where internal variability constitutes the major source of uncertainty, the potential impact of reducing model uncertainty on the signal-to-noise ratio of the climate projection is estimated to be small. We discuss the caveats of the methodology used and impact of our findings for the design of future climate models. The importance of internal variability found here emphasizes that large ensembles are a vital tool for understanding climate projections.
Resilient-Sustainable Supplier Selection Considering Health-Safety- Environment Performance Indices: A Case Study in Automobile Industry
Authors: Maddah Saeid , Bidhendi Gholamreza Nabi , Borhani Faezeh , Taleizadeh Ata Allah
Published: September 2022

Occupational safety and health are important aspect of social dimension of sustainability in the concept of sustainable supply chain. along with the environmental dimension of sustainability, helps organizations integrated approach to health, safety and environment management to move towards sustainable development. Resilience Engineering is a new approach of safety management and an inherent ability of an organization to regulate its functions before or during disruptions, enabling it to continue operating in times of crisis or constant stress. This paper presents an integrated framework for evaluating, ranking and selecting top suppliers in terms of resilience, greenness and occupational safety and health issues. The framework is based on using expert panel meetings and Delphi method to define the criteria, and content validity ratio to measure validity of the designed framework. Besides, two Multi-Criteria Decision Methods namely the Best-Worst Method and Multi-Attributive Border Approximation Area Comparison were used to weight the criteria and ranking the suppliers. The case study to apply the designed framework is the automotive industry with focus on the suppliers of one of the biggest Automotive Companies in Iran. The results showed the criteria management commitment demonstrated the highest weight and among the indicators, adequate budget allocation for HSE actions, risk awareness, management systems and control measures for risks ranked one to four, respectively. Finally, using the designed model and conducting an audit of the studied companies, the final ranking of four suppliers was done and suggestions were made to improve the performance of the companies.
Modern Trends in the Copper-Catalyzed Synthesis of Sulfonamides
Authors: Chandra Prakash , Choudhary Neha , Lahiri Goutam K. , Maiti Debabrata , Shaikh Mobin
Published: September 2022

Sulfonamides are among the most significant class of organic compounds and key components of a wide array of pharmacophores and agrichemical. These sulphonamides are used as the chemotherapeutic agents against microorganisms. Sulfonamides possess broad spectrum pharmacological activities like antibacterial, antifungal, antiprotozoal, antiretroviral, antihypertensive and antiretroviral activity. However, due to antimicrobial resistance (AMR) has resulted in universal demand for the new generation of sulfonamide derivatives. These sulfonamides primarily inhibit multiplication of bacteria by inhibiting the folic acid synthesis. As a consequence of this scenario, several homogeneous and heterogeneous transition metal complexes have been developed for the facile synthesis of these sulfonamides. Amongst all, copper-based homogeneous and heterogeneous catalytic materials have been extensively investigated to synthesize a variety of sulfonamides due to the presence of multiple oxidation states, facile electron transfer and ability to complex with a variety of organic moieties. These copper-based catalytic systems effectively catalyze the sulfonylation of organic compounds by direct C-H functionalization of various organic molecules or by multicomponent domino reaction of various organic molecules amines, carbonyl compounds, silanes, with sulfur dioxide, sulfonyl azides or tosylamines. Herein, the present review we focus on the recent developments in the copper catalysed synthesis of sulfonamides and their biological implications.
Polynomial Stochastic Dynamical Indicators
Authors: Vasile Massimiliano , Manzi Matteo
Published: September 2022

This paper introduces three types of dynamical indicators that capturethe effect of uncertainty on the time evolution of dynamical systems. Two indica-tors are derived from the definition of Finite Time Lyapunov Exponents while athird indicator directly exploits the property of the polynomial expansion of thedynamics with respect to the uncertain quantities. The paper presents the deriva-tion of the indicators and a number of numerical experiments that illustrates theuse of these indicators to depict a cartography of the phase space under paramet-ric uncertainty and to identify robust initial conditions and regions of practicalstability in the restricted three-body problem.
Differences and trends in gastric, breast, and cervical cancer screening rates between rural and urban areas in 2007-2012 among the Korean population
Authors: Chuck Kumban Walter , Lee Yunhwan
Published: September 2022

Purpose
This study aimed at examining the ever and recommended screening inequalities of cancers (gastric, breast, and cervical) in rural and urban areas including socio-economic disparities, from 2007 to 2012 amongst Koreans.
Methodology
This cross-sectional population-based study used data from the Korean National Health and Nutrition Examination Survey (KNHANES) of 2007–2012. It included people with no previous cancer diagnosis for gastric, breast, and cervical cancers. Annual Percent Change (APC) was calculated at 95% confidence interval using STATA version 13.0 and MS Excel.
Results
In the ever cancer screening group, the screening rates and trends had an increased in both urban and rural areas: APC values were 4.6% (95% CI, 1.6 to 7.8) and 5.6% (95% CI, 2.7 to 8.6) for gastric cancers, 3.6% (95% CI, 1.5 to 5.6) and 3.6% (95% CI, -0.3 to 7.7) for breast cancers, and 0.3% (95% CI, -0.4 to 1.2) and 0.7% (95% CI, -1.0 to 1.4) for cervical cancers in urban and rural areas, respectively.
Conclusion
Cancer screening rates for gastric and breast cancers showed significant increase from 2007–2012 in both areas. More effort should be implemented and focused on the improvement of cervical cancer screening rates which showed significant lower cancer screening rates compared to the other cancers in both areas.
Cerebellar Contribution in Emotional Faces Based on a Sample of Sleep-Deprived Healthy Young Men
Authors: Chen Xiangling , Lei Shiyu , Wang Yidan , Zhang Kaiming , Wang Dan , Lai Weihong , Shao Yongcong , Liu Fangfang , Weng Xiechuan , Xu Fan
Published: September 2022

Poor sleep is a pervasive public health concern linked to failure in emotion regulation. Brain networks underlying emotional processing are focused on limbic systems and prefrontal and temporal cortices. Clinical cases suggest the role of the cerebellum in affective functioning, yet a few studies have been conducted to investigate this claim in healthy individuals. This study aimed to delineate cerebellar correlation with facial emotional processing using objective facial emotion measurement and two sessions of resting-state functional magnetic resonance imaging. Thirty-five healthy men completed 36 h of total sleep deprivation (TSD). The paired-samples t-test revealed decreased arousal levels for both positive and negative emotions. The correlation analysis showed altered cerebellar functional connectivity with the emotional processing centers (e.g., cingulate cortices, middle frontal gyrus, middle temporal gyrus, and paracingulate cortex). The reported cerebellar subregions included Crus2 and lobules VI, V, and VI–IX. The results of this study indicated facial emotional blunting after TSD and cerebellar involvement in altered affective status. Although the existing treatment targets for sleep disturbance (or sleep-induced disorders) are not as effective as expected, the improved understanding of the cerebellar contribution to emotional processing sheds light on future research directions.
Effects of changes in electrical stimulation parameters on the control of absence epilepsy
Authors: Tan Xiaolong , Zhu Rui , Xie Yan , Chai Yuan
Published: September 2022

Basal ganglia and corticothalamic circuits play important roles in the modulation of absence seizures. However, the regulation of epilepsy by pedunculopontine nucleus (PPN) in the brain is rarely studied, nor the effect of electrical stimulation parameters on absence seizures is fully investigated. Therefore, we developed a network model consisting of a simplified basal ganglia, two corticothalamic circuits and pedunculopontine nucleus. Three electrical stimulations, deep brain stimulation (DBS), 1:0 coordinate reset stimulation (CRS) and 3:2 CRS, are applied to thalamic reticular nucleus (RE) in the first corticothalamic circuit. The results show that increasing the intensity of electrical stimulation can significantly suppress absence seizures and appropriately increasing the frequency and pulse width of electrical stimulation within a certain range can also suppress absence seizures. Under the same electrical stimulation parameters, the inhibitory effect of DBS on epilepsy was better than that of 1:0 CRS and 3:2 CRS. We hope these findings can be applied to treat epilepsy patients. The advantages and functions of reduced model are remarkable and the optimal combined stimulus parameters were set theoretically. This work provides a reduced model containing PPN and a theoretical reference for future clinical stimulation experiments.
Direct Electrosynthesis of Cyclohexanone Oximefrom Cyclohexanone and Nitrite in Water at Ambient Conditions
Authors: Wu Yongmeng , Zhao Jinghui , Wang Changhong , Li Tieliang , Zhao Bohang , Song Ziyang , Zhang Bin
Published: September 2022

Cyclohexanone oxime, an important feedstock in nylon-6 production, is conventionally synthesized through cyclohexanone-hydroxylamine (NH2OH) and cyclohexanone ammoxidation methodologies. These strategies require complicated procedures, high temperatures, noble metal catalysts, and toxic SO2or H2O2 usage. Here we report a one-step electrochemical strategy to synthesize cyclohexanone oxime from nitrite (NO2−) and cyclohexanone under ambient conditions using a low-cost Cu-S catalyst, avoiding complex procedures and H2O2 usage. 92% yield, 99% selectivity, and 26% Faradic efficiency of cyclohexanone oxime are achieved. The reaction undergoes a NO2-→ NH2OH→oxime reaction pathway. The amplified electrolysis experiment and techno-economic analysis confirm the practical potential of our method. This study opens a mild, economical, and sustainable way for the alternative/complementary production of cyclohexanone oxime.
Differential proteomic profile of lumbar and ventricular cerebrospinal fluid
Authors: Rostgaard Nina , Olsen Markus Harboe , Ottenheijm Maud , Drici Lylia , Simonsen Anja H. , Plomgaard Peter , Gredal Hanne , Poulsen Helle Harding , Zetterberg Henrik , Blennow Kaj , Hasselbalch Steen G , MacAulay Nanna , Juhler Marianne
Published: September 2022

Background: Pathological cerebral conditions may manifest in altered composition of the cerebrospinal fluid (CSF). Although diagnostic CSF analysis seeks to establish pathological disturbances in the brain proper, CSF is generally sampled from the lumbar compartment for reasons of technical ease and ethical considerations. We here aimed to compare the molecular composition of CSF obtained from the ventricular versus the lumbar CSF compartments to establish a relevance for employing lumbar CSF as a proxy for the CSF bathing the brain tissue.
Methods: CSF was collected from 46 patients with idiopathic normal pressure hydrocephalus (iNPH) patients during their diagnostic workup (lumbar samples) and in connection with their subsequent CSF diversion shunt surgery (ventricular samples). The mass-spectrometry-based proteomic profile was determined in these samples and in addition, selected biomarkers were quantified with ELISA (S100B, neurofilament light (NfL), amyloid-β (Aβ40, Aβ42), and total tau (T-tau) and phosphorylated tau (P-tau) forms). The latter analysis was extended to include paired porcine samples obtained from the lumbar compartment and the cerebromedullar cistern closely related to the ventricles.
Results: In total 1,231 proteins were detected in the human CSF. Of these, 216 distributed equally in the two CSF compartments, whereas 22 were preferentially (or solely) present in the ventricular CSF and four in the lumbar CSF. The selected biomarkers of neurodegeneration and Alzheimer’s disease displayed differential distribution, some with higher (S100B, T-tau, and P-tau) and some with lower (NfL, Aβ40, Aβ42) levels in the ventricular compartment. In the porcine samples, all biomarkers were most abundant in the lumbar CSF.
Conclusions: For a range of CSF proteins and biomarkers, one can reliably employ lumbar CSF as a proxy for ventricular CSF. However, the overall proteomic profile differs between these compartments, and so does the distribution of clinically employed biomarkers. It is therefore important to verify the compartmental preference of the proteins or biomarkers of interest prior to extrapolating from lumbar CSF to that of the ventricular fluid bordering the brain.
Influence of antibiotic therapy on clinical outcomes of patients with Stenotrophomonas maltophilia blood stream infection in the intensive care unit
Authors: Lai Jiun-Ji , Siu L. Kristopher , Chang Feng-Yee , Lin Jung-Chung , Yu Ching-Mei , Wu Rui-Xin , Wang Ching-Hsun
Published: September 2022

Background: The aim of this study was to assess the relationship between appropriate antibiotic therapy and the outcome in intensive care unit (ICU) patients with bloodstream infection (BSI) due to Stenotrophomonas maltophilia.
Methods: ICU patients with monomicrobial BSI due to S. maltophilia admitted during the period from January 2004 to December 2019 were included. The included patients were divided into two groups—those with- and without appropriate antibiotic therapy after BSI—for comparison. The primary outcome was the relationship between appropriate antibiotic therapy and 14-day mortality. The secondary outcome was the influence of different antibiotic therapies: levofloxacin- and trimethoprim–sulfamethoxazole-containing regimens, on 14-day mortality.
Results: A total of 214 ICU patients were included. One hundred thirty-three patients receiving appropriate antibiotic therapy after BSI had a lower 14-day mortality than those (n = 81) who did not receive an appropriate antimicrobial therapy (10.5% vs. 46.9%, p < 0.001). After a propensity score matching, 61 well-balanced matched pairs showed similar results of regarding the association of appropriate antibiotic therapy with a lower 14-day mortality (11.5% vs. 39.3%, p< 0.001). Furthermore, proportional hazards regression for propensity score-matched cohort consistently revealed that APACHE score (hazard ratio (HR) 1.118, 95% confidence interval (CI) 1.056–1.184, p < 0.001) and appropriate antibiotic therapy (HR 0.222, 95% CI 0.095–0.518, p = 0.001) were independent factors associated with 14-day mortality. Among ICU patients receiving appropriate antibiotic therapy, those receiving a levofloxacin-containing regimen exhibited a trend toward lower 14-day mortality after BSI onset than those receiving a trimethoprim–sulfamethoxazole regimen (HR 0.233, 95% CI 0.050–1.084, p = 0.063)
Conclusion: Appropriate antibiotic therapy was associated with decreased 14-day mortality in ICU patients with S. maltophilia BSI. No significant efficacy differences were noted between levofloxacin- and trimethoprim–sulfamethoxazole-containing regimens in treating S. maltophilia BSI.
Systematic Health Artificial Intelligence (SHAI) - A pathology based NLP model for improved predictive diagnostics in personalised medicine
Authors: Hussain Shaista
Published: September 2022

The Systematic Health Artificial Intelligence (SHAI) model trains on data from medical records and clinical laboratory results to temporally identify disease markers with subsequent pathologies, more efficiently and accurately than is done in the current analog practice. The aim of the SHAI model is to gauge a patient’s medical prognostic status based on a conglomerate of data to predict lurking, occult or comorbid pathologies.Newfound associations and predictions would support clinicians in terms of comprehensively visualising a patient’s health profile, both in real-time and for the future. Proxy findings would also help to establish personalised references ranges for clinical pathological investigations of body fluids. The SHAI model processes EMR progress text-based notes through a NLP ‘Bag of Words’ system, which enables the neural network to train in word representation and ‘weigh’ words of proximity. Using ‘forward propagation’ of the vectors will allow for output activation from hidden and non-hidden layers of the developing neural network architecture, to then use ‘multiclass classification’ as the vector contents grow with new data. This manuscript identifies 8 key questions to be addressed by diagnostic ML models and explains SHAI’s design as it pertains to maximising human benefit and minimising bias. Despite the automaticity of this laboratory medicine solution, physician end-users remain essential to the diagnostic process and final clinical judgements.
International Inequity Patterns in Youth and Young Adults Related to COVID-19: Advancing Sustainable Development Goals on Well-Being, Education, and Employment
Authors: MacNeil Patricia , Khare Anshuman , Jugdev Kam
Published: September 2022

COVID-19 has threatened physical and mental health and reduced overall wellbeing. Wellbeing has declined significantly since the pandemic, particularly within younger sub-populations aged 15-29. Past disasters and current crises indicate that decreased wellbeing can have serious long-term health, social, and financial effects for the individual and society. This is particularly concerning for younger people whose lives and livelihoods are developing. Research indicates that supports put in place at younger ages typically lead to multiple gains in growth and development. Our objective was to use a scoping review spanning 2020-2021 to map the patterns of international inequity on young people in terms of education, employment, and mental health. As educators, we note the special capacity within the United Nations sustainable development goals to address these challenges. With its inherent focus on wellbeing, the sustainable development goals framework can be used to guide the strategic processes to address wellbeing, especially in these vulnerable subpopulations. The review enabled us to identify preliminary steps for strategy development related to policy and for educators to consider in supporting youth and young adults. Many universities have established processes for advancing sustainable development goals. Educators’ expertise and capacity to effect change can be harnessed to improve mental health and wellbeing locally while contributing to longer-term sustainable development within society. The authors stated that wellbeing is a beacon for the future. Monitoring wellbeing and taking steps to address its decline, especially in the young, must be a priority as they are the future leaders of society. Youth and young adults will also bear the brunt of the economic and social burden due to the pandemic. By investing in the wellbeing of today’s youth and young adults there are opportunities to «pay it forward» so that better outcomes may be realized in the future.
Utilizing Almond Oil with Vitamin E as an Alternative Fixative to Formalin
Authors: Sachdev Sanpreet Singh , Chettiankandy Tabita Joy , Sardar Manisha Ahire , Kende Prajwalit Prakash , Gaikwad Rajesh Prabhakar , Fernandes Lynette Custodio
Published: September 2022

Introduction: The health hazards resulting from exposure to formalin have given rise to the need of developing safer alternative fixatives. Almond oil has been widely used in the aromatherapy and cosmetic industry for its good penetrating and skin-rejuvenating properties, whereas vitamin E is a widely known anti-oxidant. The present study aimed to test the fixative efficacy of almond oil with vitamin E as compared to formalin.
Material and Methods: The present study was conducted on 42 tissue specimens obtained by crown lengthening procedure or other minor surgical procedures. The specimens were divided into two groups- 21 specimens in the study group were fixed in oil fixative while others were fixed in formalin for 24 hours. Routine histopathological procedures were done and the histomorphological parameters related to the preservation of tissue architecture as well as cellular details were assessed.
Result: The preservation of tissue architecture and cellular details in tissues fixed in AO were comparable to that of tissues fixed in formalin. Although statistically non-significant, all the three investigators agreed that oil-fixed tissues exhibited superior nuclear details as compared to formalin.
Conclusion: Almond oil with vitamin E can be effectively used for the fixation of tissues, providing results that are comparable to formalin-fixed tissues. The non-toxic, non-irritant chemical nature of almond oil coupled with its ease of availability, enable it to be utilized safely even in remote areas
The Extent to Which Multinational Organizations Follow Csr and Adjust Csr Strategy According to Regional Differences: a Comparitve Study Between Nokia and Coca Cola
Authors: Alkhudierat Noor Ahmad
Published: September 2022

Corporate social responsibility is a relatively new concept that became widespread about three decades ago. Since then, it has become one of the most important aspects of designing and implementing business policies and strategies in organizations around the world. This paper aims to study the CSR reports of Nokia and Coca-Cola to discover the extent to which global companies apply the principles of corporate social responsibility in the following three aspects: the environment, employees, and society. The current study compares the policies of global companies in these areas and aims to determine whether global companies alter their social responsibility policies in different places around the world based on the cultural and social differences in which they perform their business activities. The research methodology is qualitative analysis based on secondary data such as previous studies and the analysis of the 2018 CSR reports of Nokia and Coca-Cola. The study concluded that the two companies do not apply social responsibility policies to the same extent and that companies do not follow different policies in different countries around the world.
Civil szervezetek leadership központú megközelítése – a Rotary példája
Authors: Paár Dávid , Pirger Tamás
Published: September 2022

A témához kapcsolódó szakirodalmi és történeti áttekintés, ismertetés után a tanulmány célja rávilágítani, hogy leadership szempontból hogyan jellemezhető egy önkéntességen alapuló civil szervezet, szem előtt tartva a szervezet tagjainak speciális motivációit, illetve megvizsgálni, hogy ezen aspektusból mik a tények, és mik az elvárások a Rotary esetében a hazai klubvezetők felé. A vizsgálathoz a tanulmány szerzői Tannenbaum és Schmidt hatalom-részvétel (leadership) modellje alapján készítettek el egy kérdőívet, és használták azt fel a kutatáshoz. A kapott adatok statisztikai módszerekkel – szocio-demográfiai ismérvek mentén – való kiértékelése után értékelték, illetve összehasonlították a szervezetnél észlelt és elvárt vezetési stílusokat az autokrata és demokrata vezetés által definiált határok között.
Epistemologias, gênero e dogmatismo científico
Authors: Martínez-Ávila Daniel , Mello Mariana Rodrigues Gomes de
Published: September 2022

Há uma filosofia da diferença que precisa ser mais considerada nos nossos tempos, visto que se opõe à tradição filosófica identitária dos pré-socráticos à atualidade, que se apegou obstinadamente à ideia de identidade, que vislumbra o real, somente através da referência ao idêntico. Nessa perspectiva, os anseios e peculiaridades dos mais diversos movimentos sociais precisam ser ouvidos de modo mais efetivo pela filosofia e pela ciência. Mesmo nas ciências exatas, a teoria não é eterna, quanto mais nas sociais aplicadas, como é na ciência da informação, e consequentemente, na organização do conhecimento. Posto isto, este trabalho tem como objetivo inter-relacionar alguns aspectos históricos da epistemologia geral com as epistemologias feministas, destacando-se a corrente pós-estruturalista. E assim, compreendermos alguns dos seus desdobramentos na organização do conhecimento, a fim de percebermos se ela está disposta a incorporar novas práticas, a partir de reinvindicações de movimentos, como o feminista. Constatamos que além de toda historicidade das relações de poder que tem raízes profundas e muito antigas, há nos dias hodiernos um grupo despreocupado em ratificar novas práticas mais humanizadas e coerentes às várias esferas, dentre as quais está a organização do conhecimento, por questões não só políticas, mas econômicas.
Patients with Polyvascular Disease: A Very High-risk Group
Authors: Manolis Antonis A. , Manolis Theodora A. , Manolis Antonis S.
Published: September 2022

Polyvascular disease (PolyvascDis) with atherosclerosis occurring in >2 vascular beds (coronary,
carotid, aortic, visceral and/or peripheral arteries) is encountered in 15-30% of patients who experience
greater rates of major adverse cardiovascular (CV) events. Every patient with multiple CV risk
factors or presenting with CV disease in one arterial bed should be assessed for PolyvascDis clinically
and noninvasively prior to invasive angiography. Peripheral arterial disease (PAD) can be readily diagnosed
in routine practice by measuring the ankle-brachial index. Carotid disease can be diagnosed by
duplex ultrasound showing % stenosis and/or presence of plaques. Coronary artery disease (CAD) can
be screened by determining coronary artery calcium score using coronary computed tomography angiography;
further, non-invasive testing includes exercise stress and/or myocardial perfusion imaging or
dobutamine stress test, prior to coronary angiography. Abdominal ultrasound can reveal an abdominal
aortic aneurysm. Computed tomography angiography will be needed in patients with suspected mesenteric
ischemia to assess the mesenteric arteries. Patients with the acute coronary syndrome and concomitant
other arterial diseases have more extensive CAD and poorer CV outcomes. Similarly, PolyvascDis
in patients with carotid disease and/or other PAD is independently associated with an increased risk for
all-cause and CV mortality during long-term follow-up. Treatment of patients with PolyvascDis should
include aggressive management of all modifiable risk factors by lifestyle changes and drug therapy,
with particular attention to patients who are commonly undertreated, such as those with PAD. Revascularization
should be reserved for symptomatic vascular beds, using the least aggressive strategy in a
multidisciplinary vascular team approach.
Design, Stress Analysis, and FEA Prediction of Nutation Drive with Face
Gear
Authors: Wang Guangxin , Zhu Lili , Li Linjie , Wang Jiayu
Published: September 2022

Background:

Nutation face gear transmission is a patent about a new type of transmission
based on meshing between two face gears. It replaces spur gear with internal face gear to form a “faceface” meshing gear pair and actualizes its deceleration function by combining the nutation principle,
which has the advantages of both face gear and nutation drive.

Objective:

The purpose of this paper is to study the designing and manufacturing of a nutation face gear
reducer to derive the force calculation formulas of the face gear, input shaft and bearings, calculate the
contact stress of tooth surface and bending stress of tooth root, determine the basic parameters of the
prototype, and analyze the processing points for the core parts of the prototype.

Methods:

Using the dynamic meshing force analysis method by combining it with modern digital design and manufacturing methods, the designing and manufacturing of a nutation face gear reducer are
studied.

Results:

In the theoretical calculation, the maximum contact stress of the fixed side tooth surface is
about 433MPa, and the average contact stress is about 345MPa; the maximum contact stress of the tooth
surface on the rotating side is about 579MPa, with an average of about 502MPa; the comparison of
which with the finite element analysis results verifies the theoretical calculation results.

Conclusion:

The dynamic meshing force analysis method of nutation face gear transmission is deduced
and given. Based on this, gear tooth surface transient contact stress and tooth root bending stress are
calculated.
Multidrug-Resistant Acinetobacter baumannii: An Emerging Aspect
of New Drug Discovery
Authors: Jain Chakresh Kumar , Mittal Khushi R. , Jain Nandini , Srivastava Poornima
Published: September 2022

Background:

Acinetobacter baumannii is an opportunistic multidrugresistant,
aerobic, glucose non-fermentative, and oxidative-negative coccobacilli bacteria.
This life-threatening nosocomial infection is associated with immunocompromised
patients.

Objective:

This review aims to investigate the multiple drug resistance mechanisms and
new emerging diagnostics & treatments for Acinetobacter baumannii.

Methods:

All the articles that were most relevant to A. baumannii virulence and drug
resistance mechanisms were founded by a literature search on PubMed. Google Patents
were used to find discoveries related to diagnostics and treatment.

Results:

Efflux pumps, β-lactamases, aminoglycosides, outer membrane proteins, and
alteration of the target sites were identified in the Acinetobacter baumannii pathogen as
the most prevalent drug resistance mechanisms. Gene detection, peptide detection, and
antigen-antibody-associated detection were the latest diagnostics. Novel antimicrobial
peptides, sterilization techniques using blue light, and combination therapies are being
developed to effectively treat A. baumannii infections.

Conclusion:

This review concludes that new drugs and formulations with high efficiency,
low cytotoxicity, and no nephrotoxicity are in absolute need. In the near future, we
can expect omics technology to play a significant role in discovering new drugs and potential
targets.
The Potential Therapeutic Properties of Prunetin against Human Health
Complications: A Review of Medicinal Importance and Pharmacological
Activities
Authors: Patel Dinesh Kumar , Patel Kanika
Published: September 2022

Background:

Flavonoids are polyphenolic compounds found to be present in nature
and abundant in flowers and fruits. Flavonoidal class phytochemicals have gained interest in the
scientific field because of their important pharmacological activities. Several scientific studies
have revealed anti-bacterial, anti-oxidant, anti-fungal, analgesic, anti-viral, anti-inflammatory,
anti-tumor, anti-parasitic and anti-allergic activities of flavonoidal class phytochemicals. Prunetin
is an O-methylated isoflavone that belongs to the phytochemical phytoestrogen class, found to be
present in licorice, red cherry, soybean and legumes.

Methods:

Biological potential and pharmacological activities of prunetin have been investigated
in the present work through scientific data analysis of numerous scientific research works. Numerous
literature databases have been searched in order to collect the scientific information on
prunetin in the present work. Pharmacological activities of prunetin have been investigated in the
present work through literature data analysis of different scientific research works. Scientific data
have been collected from Google Scholar, Google, PubMed, Science Direct and Scopus. Analytical
data on prunetin has been collected from literature sources and analyzed in the present work.

Results:

Scientific data analysis revealed the biological importance of prunetin in medicine.
Prunetin was found to be present in the pea, peach, Oregon cherry, skimmed cheese, cheese, cow
kefir and goat kefir. Prunetin is also present in the Prunus avium, Andira surinamensis, Butea superba,
Dalbergia sympathetica, Ficus nervosa, Pterospartum tridentatum and Pycnanthus angolensis.
Pharmacological data analysis revealed the biological importance of prunetin on bone disorders,
cancers, especially hepatocellular carcinoma, urinary bladder cancer, gastric cancer, ovarian
cancer, human airway, gut health and enzymes. Scientific data analysis revealed biological effectiveness
of prunetin for their angiogenic effects, anti-inflammatory, anti-oxidant, antimicrobial,
estrogenic and vasorelaxant potential. Analytical data revealed the importance of modern
analytical techniques for qualitative and quantitative analysis of prunetin in the scientific
fields.

Conclusion:

Scientific data analysis in the present investigation revealed the biological importance
and pharmacological activities of prunetin in medicine.
Sleep disorders in meningoencephalitis with adjustment disorders
Authors: Siahaan Sarah Endang S. , Ariani Ni Ketut Putri , Utami Desak Ketut Indrasari
Published: September 2022

Many patients with medical disorders, such as meningoencephalitis are evaluated by psychiatrists complaining of sleep problems as one of the symptoms. A 65-years old married male patient who was currently unemployed was interviewed by a psychiatrist in an uncomfortable reclining position. The patient had been hospitalized for 8 days prior to the interview with a history of being unconscious. The patient showed disorganized speech, tried to pull the intravenous line, and hit his wife. The patient said that at this time, he was unable to sleep due to the throbbing headaches, nauseous, and frequent urination at night. Thus, the patient felt uncomfortable, tired, and drowsy in the morning. Those symptoms got worse in the last week.  The patient never had sleep problems before. The psychiatric status showed an appropriate appearance, uncomfortable looks, adequate verbal and visual contact, clear consciousness, dysphoric mood and affect which was congruent, logical realist coherent thought process, and a preoccupation of headache. There was no hallucination or illusion, but mixed type insomnia was found. The patient was diagnosed with adjustment disorder with predominant symptoms and sleep disturbances (F43.28).
STRATEGI PEMBELAJARAN BAHASA INGGRIS MELALUI COLLABORATIVE WRITING DAN SYNCHRONOUS CORRECTIVE FEEDBACK BAGI GURU SMA/SMK DI SURABAYA
Authors:   Universitas PGRI Adi Buana Surabaya, Rifai Irfan , Syahria Nukmatus ,   Universitas PGRI Adi Buana Surabaya, Andanty Ferra Dian ,   Universitas PGRI Adi Buana Surabaya, Nabhan Salim ,   Universitas PGRI Adi Buana Surabaya, Siyaswati Siyaswati ,   Universitas PGRI Adi Buana Surabaya
Published: September 2022

The strategy of collaborative writing as a means of increasing the success of learning English has been widely studied. Most of the research on the two strategies aforementioned emphasized more on the perspective of students and teachers using conventional methods. However, research on how to use collaborative writing strategies and feedback using Google Docs is least investigated. Therefore, this article aims to describe the process of implementing English language learning through collaborative writing training for Senior High School teachers in Surabaya by using Google Docs application. This training was conducted by English Department of the University of Adi Buana Surabaya in collaboration with MGMP (Musyawarah Guru Mata Pelajaran) Bahasa Inggris or English Teacher Working Group as a part of community service. It is held online and was attended by 65 participants for three days. The data were obtained from the survey, language teachers’ reflections, as well as interview and analysed using content analysis. The results of the data analysis show that in addition to increasing teacher knowledge about the two learning strategies – collaborative writing and corrective feedback, the teachers also get hands-on experience applying these learning strategies with the help of technology applications on Google. Moreover, the collaborative writing and corrective feedback learning strategy through Google Docs provides new nuances in learning English and help motivates teachers to write in groups which in turn can increase interest in publication as part of increasing teacher professionalism.
PENYEDIAAN SARANA INFORMASI CERITA SEJARAH DALAM BAHASA INGGRIS DI DAERAH WISATA ‘KAMPUNG HERITAGE KAYOETANGAN’ MALANG – JAWA TIMUR
Authors:   Universitas Brawijaya, Isnaini Moh. Hasbullah , Degeng Putu Dian Danayanti ,   Universitas Brawijaya, Kusumawardani Irene Nany ,   Universitas Brawijaya
Published: September 2022

Perkembangan pariwisata di Kota Malang, sebaiknya diimbangi dengan peningkatan kemampuan komunikasi, terutama bahasa asing (bahasa Inggris) bagi para pelaku wisata dan fasilitas wisata yang mampu mengkomunikasikan hal-hal yang mendasar bagi wisatawan asing, seperti penunjuk jalan maupun keterangan/cerita dari suatu spot wisata. Kampung Heritage Kayoetangan (KHK) sebagai salah satu destinasi wisata kampung tematik di kota Malang membutuhkan fasilitas informasi sejarah yang dapat menceritakan asal-usul dan warisan budaya dari spot-spot bersejarah yang ada disana. Oleh karena itu, pengabdian ini dilakukan untuk membantu dalam penyediaan sarana informasi cerita-cerita sejarah di KHK, dan memberi nilai tambah sehingga para pelaku wisata disana dapat terbantu untuk mengkomunikasikan nilai sejarah dari tempat-tempat yang mereka tinggali.
Child studies through the lens of applied family social systems theory
Authors: Dunst Carl J.
Published: September 2022

The foundations of an applied family social systems theory for explaining the multiple determinants of child well-being, learning, and development, parenting beliefs, behavior and practices, and family well-being are described. The theory is derived from tenets of Bronfenbrenner’s ecological systems theory and other social, family, and contextualized theories. The applied theory was used to develop an activity setting model of young children’s everyday learning opportunities and a family systems intervention practices model for ensuring parents and other caregivers have the time and psychological energy to provide young children with development-instigating and development-enhancing learning opportunities in the contexts of everyday family and community life. Results from three different lines of research are described which provide support for the applied systems model and the two associated intervention models. Results showed that different child characteristics, setting characteristics, parenting behavior and practices, family and social systems variables, and practitioner measures were empirically related to variations in child, parent, and family outcomes. There were also discernable pathways of influence between family systems intervention model practices, parenting practices, and child outcomes mediated by parent self-efficacy beliefs and parent well-being. The contributions of the theory, models, and research findings to child studies are described.
Advanced Students’ Knowledge of Vocabulary in a First and Second Language
Authors: Karlsson Monica
Published: September 2022

This book offers a comprehensive investigation into advanced students’ knowledge of vocabulary in their L1 and L2. This cross-sectional study examines the qualitative and quantitative aspects of students’ vocabulary knowledge in subfields such as suffixation, idioms and proverbs, multi-word verbs, polysemous words and inferencing skills.
Investigación de parámetros bioquímicos y perfil de citocinas en ovejas con ectima contagioso
Authors: Polat-Dinçer Pelin Fatoş , Şahan Adem
Published: September 2022

Objective. Contagious ecthyma is a worldwide zoonotic disease with a wide host range and high morbidity that causes serious economic losses.  Materials and methods. 28 unvaccinated sheep aged 1-4 months showing clinical symptoms of ecthyma and 10 healthy sheep in the same age range were used. Measurements were taken of ALB, ALT, BUN, CHOL, CRE, GGT, GLU, TBIL and TP. The obtained crusts were homogenized before performing extraction and PCR. ELISA was used to determine IL-2 and IL-4 levels in the PCR-positive animal serum. Results. The biochemical analysis revealed that ALT, BUN, GGT, and CRE values in infected animals were significantly higher than in the control group (p=0.000 and p= 0.001) whereas TP and GLU values were significantly lower (p=0.000). There were no significant differences in ALB, CHOL, and TBIL values (p=0.1, p=0.05, p=0.08).  Regarding the immune profile, infected animals had significantly higher IL-2 (%28) and IL-4 (%60) levels than the control group (p=0.008 and p=0.001). Conclusion. The findings indicate that Th1 (IL-2) and Th2 (IL-4) cytokines coexist while the dominant cytokine response in infected animals is Th2. It is thought that the result will help us better understand the pathogenesis and treatment options of the disease.
Examen de adenovirus con métodos moleculares y patológicos en casos de pneumonía ovina
Authors: Dörtbudak Muhammet Bahaeddin , Sağlam Yavuz Selim , Yıldırım Serkan , Timurkan Mehmet Özkan
Published: September 2022

Objective. Reveal adenoviruses (AdV) that cause pneumonia in sheep and examine pathologic changes in the pulmonary and mediastinal lymph nodes of naturally infected adenovirus-positive specimens. Material and method. For this purpose, 1459 lungs of sheep slaughtered in a slaughterhouse were macroscopically examined, and pneumonia lesions were detected in 88 (6.03%) of these. The paraffinized tissue sections of these specimens with pneumonia were examined with the immunohistochemical (IHC) and indirect immunofluorescence (IF) methods, whereas their tissue homogenates were examined using the Antigen ELISA and PCR methods for adenovirus positivity. Results. Accordingly, the prevalence of adenoviruses was determined as 19.3% for IHC, 22.7% for IF, 20.5% for ELISA and 13.6% for PCR. Hematoxylin-eosin (HE) staining was performed to examine histopathological changes in the specimens that were naturally infected with adenoviruses. The histopathological examinations of the naturally infected lung specimens revealed mainly interstitial pneumonia, as well as catarrhal and verminous pneumonia findings. Consequently, it was determined that the most effective methods in the detection of adenoviruses in sheep pneumonias were found respectively as IF, ELISA, IHC and PCR. The finding that adenoviruses were observed only in the mediastinal lymph nodes of some specimens in the immunopathological methods suggested that the latency. Conclusions. The presence of adenoviruses in sheep pneumonia cases was determined with the indirect immunofluorescence, antigen ELISA and PCR methods for the first time. The possibility of the latent nature of adenovirus infection in these species was also discussed for the first time.
Sleep Disorders in Older People with Special Focus on Parkinson’s Disease
Authors:   Neurology Department, Liverpool Hospital, Liverpool 2170, NSW, Australia, Beran Roy G ,   Conjoint Professor, South Western Sydney Clinical School, University of NSW, Sydney, NSW, Australia,   Ingham Institute for Medical Research, South Western Sydney Area Health Service, NSW, Australia,   Professor, Griffith University, Southport, Qld, Australia,   Professor, Chair, Sechenov Moscow First State University, Moscow, Russia,   Conjoint Professor, Western Sydney University, Sydney, NSW, Australia
Published: September 2022

This paper examines sleep disorders in older people, focusing on Parkinson’s disease (PD). It defines PD and explores those conditions associated with sleep disorders and their relationship to PD. It identifies specific conditions which cause sleep disoders in patients with PD, namely: REM sleep behaviour disorder (RDB) which may be a precursor to PD; obstructive sleep apnoea (OSA) which is very prevalent amongst people with PD; depression and mood disorders which both increase with age and are more common in people with PD; nocturia which increases with age and has a negative impact on those with PD; restless leg syndrome (RLS) which some argue is an accompaniment but others argue against this, due to the relationship to iron metabolism, although both respond to dopamine medications; and excessive daytime sleepiness (EDS) which completes the picture. The paper offers suggestions to the approach to these conditions and offers suggestions for therapeutic intervention.