bluuebunny/crossref_metadata_2025 huggingface dataset:
Crediting Invisible Work: Congress and the Lawmaking Productivity Metric (LawProM)
Authors: EATOUGH MANDI , PREECE JESSICA R.
Published: May 2024

Congressional observers have long been interested in the distinction between legislative “workhorses” and “showhorses.” However, when scholars operationalize this by measuring legislator productivity, they often neglect many realities of modern lawmaking by focusing on the traditional bill sponsorship and passage process. To better align measurement with practice, we compile widely available data on bill sponsorship, cosponsorship, and amendments; we also use text-as-data methods to credit instances of behind-the-scenes lawmaking via text reuse between bills. We weight achievements from each of these lawmaking methods to create the Lawmaking Productivity Metric for House Members of the 101–113th Congresses. Including methods of lawmaking beyond bill sponsorship provides important insights about who the congressional workhorses are. In particular, we find that traditional measures systematically undercount the legislative successes of women and likely Black Members of Congress because they disproportionately legislate in less visible ways.
A TROPICAL ANALOGUE OF THE LEMMA ON THE LOGARITHMIC DERIVATIVE
Authors: HALONEN JUHO
Published: May 2024

The tropical analogue of the lemma on the logarithmic derivative is generalised for noncontinuous tropical meromorphic functions, that is, piecewise linear functions that may have discontinuities. In addition, two Borel type results are generalised for piecewise continuous functions. With the generalisation of the tropical analogue of the lemma on the logarithmic derivative, several tropical analogues of Clunie and Mohon’ko type results are also automatically generalised for noncontinuous tropical meromorphic functions.
Echinococcus multilocularis infection affects risk-taking behaviour in Microtus arvalis: adaptive manipulation?
Authors: Martini Matilde , Cioli Teila , Romig Thomas , Gagliardo Anna , Giunchi Dimitri , Zaccaroni Marco , Massolo Alessandro
Published: May 2024

Manipulation of host behaviour by parasites to enhance transmission to the next host is a fascinating phenomenon that has interested scientists since the 1970s. It has been proposed that infection with the cestode Echinococcus multilocularis produces an impairment of the antipredatory behaviour in the rodent intermediate host common vole, Microtus arvalis, which may facilitate transmission of the tapeworm to the canid final host. In this study, we observed the behaviour of infected common voles at 12 weeks post-infection, when protoscoleces production and maturation commonly occurs, in order to assess behavioural changes compared to uninfected controls, that might ease predation in the wild. Infected and uninfected voles were monitored for 24 h to observe their spontaneous activity. In addition, the next day, both infected and uninfected voles were subjected to 4 different behavioural tests: open field test, barrier test, platform test and air-puff test in a running wheel. No significant difference between uninfected and infected voles emerged during the behavioural tests. However, observation of spontaneous activity revealed that infected voles increased their feeding frequency and spent significantly more time above bedding even when not eating, compared to the uninfected controls. In the wild, these behavioural changes increase the animals exposure to predators, raising their chance of becoming prey. These findings are the first direct evidence consistent with behavioural manipulation by E. multilocularis on common voles.
Coherence and comprehensibility in second language speakers’ academic speaking performance
Authors: Tsunemoto Aki , Trofimovich Pavel
Published: May 2024

This study examined the role of discourse organization in second language (L2) comprehensibility ratings. Twelve English for Academic Purposes teachers listened to 60 L2 speech samples elicited through a TOEFL–type integrated speaking task, evaluating each sample for comprehensibility and coherence (perceived interconnectedness of ideas). The samples were analyzed for the occurrence of discourse features at micro and macro levels. Results revealed a strong association between coherence and comprehensibility (r= .70). Whereas L2 speakers’ use of additive connectives (e.g.,and) uniquely predicted comprehensibility, ordering of ideas and source–speech similarity in speakers’ performances predicted coherence. Lexical overlaps predicted both constructs. Findings underscore the importance of coherence to comprehensible academic L2 speech demonstrating that the two constructs include partially overlapping yet distinct characteristics.
Crystal structure of alectinib hydrochloride Type I, C30H35N4O2Cl
Authors: Kaduk James A. , Rost Megan M. , Dosen Anja , Blanton Thomas N.
Published: May 2024

The crystal structure of alectinib hydrochloride has been solved and refined using synchrotron X-ray powder diffraction data and optimized using density functional theory techniques. Alectinib hydrochloride crystallizes in space group P21/n (#14) with the following parameters: a = 12.67477(7), b = 10.44076(5), c = 20.38501(12) Å, β = 93.1438(7)°, V = 2693.574(18) Å3, and Z = 4 at 295 K. The crystal structure consists of stacks of molecules along the b-axis, and the stacks contain chains of strong N–H⋯Cl hydrogen bonds. One density functional theory calculation moved a proton from an N atom to the Cl, but another calculation yielded a more chemically reasonable result. The powder pattern has been submitted to ICDD for inclusion in the Powder Diffraction File™ (PDF®)
Neuropsychological tests associated with symptomatic HIV-associated neurocognitive disorder (HAND) in a cohort of older adults in Tanzania
Authors: Fotheringham Lachlan , Lawson Rachael A. , Urasa Sarah , Boshe Judith , Mukaetova-Ladinska Elizabeta B. , Rogathi Jane , Howlett William , Dekker Marieke C.J. , Gray William K. , Evans Jonathan , Walker Richard W. , Makupa Philip C. , Paddick Stella-Maria
Published: May 2024

Objective:

Human immunodeficiency virus (HIV)-associated neurocognitive disorder (HAND) prevalence is expected to increase in East Africa as treatment coverage increases, survival improves, and this population ages. This study aimed to better understand the current cognitive phenotype of this newly emergent population of older combination antiretroviral therapy (cART)-treated people living with HIV (PLWH), in which current screening measures lack accuracy. This will facilitate the refinement of HAND cognitive screening tools for this setting.

Method:

This is a secondary analysis of 253 PLWH aged ≥50 years receiving standard government HIV clinic follow-up in Kilimanjaro, Tanzania. They were evaluated with a detailed locally normed low-literacy neuropsychological battery annually on three occasions and a consensus panel diagnosis of HAND by Frascati criteria based on clinical evaluation and collateral history.

Results:

Tests of verbal learning and memory, categorical verbal fluency, visual memory, and visuoconstruction had an area under the receiver operating characteristic curve >0.7 for symptomatic HAND (s-HAND) (0.70–0.72; p < 0.001 for all tests). Tests of visual memory, verbal learning with delayed recall and recognition memory, psychomotor speed, language comprehension, and categorical verbal fluency were independently associated with s-HAND in a logistic mixed effects model (p < 0.01 for all). Neuropsychological impairments varied by educational background.

Conclusions:

A broad range of cognitive domains are affected in older, well-controlled, East African PLWH, including those not captured in widely used screening measures. It is possible that educational background affects the observed cognitive impairments in this setting. Future screening measures for similar populations should consider assessment of visual memory, verbal learning, language comprehension, and executive and motor function.
From speculative to real: community attitudes towards government COVID-19 vaccine mandates in Western Australia from May 2021 to April 2022
Authors: Attwell Katie , Roberts Leah , Rizzi Marco
Published: May 2024

Many governments employed mandates for COVID-19 vaccines, imposing consequences upon unvaccinated people. Attitudes towards these policies have generally been positive, but little is known about how discourses around them changed as the characteristics of the disease and the vaccinations evolved. Western Australia (WA) employed sweeping COVID-19 vaccine mandates for employment and public spaces whilst the state was closed off from the rest of the country and world, and mostly with no COVID-19 in the community. This article analyses WA public attitudes during the mandate policy lifecycle from speculative to real. Qualitative interview data from 151 adults were analysed in NVivo 20 via a novel chronological analysis anchored in key policy phases: no vaccine mandates, key worker vaccine mandates, vaccine mandates covering 75% of the workforce and public space mandates. Participants justified mandates as essential for border reopening and, less frequently, for goals such as protecting the health system. However, public discourse focusing on ‘getting coverage rates up’ may prove counter-productive for building support for vaccination; governments should reinforce end goals in public messaging (reducing suffering and saving lives) because such messaging is likely to be more meaningful to vaccination behaviour in the longer term.
Optional but not qualified: Neutrality, the UN Charter and humanitarian objectives
Authors: Schmid Evelyne
Published: May 2024

Neutral States must abstain from supporting a party to a conflict with military equipment and assistance. This core aspect of the law of neutrality has not changed with the adoption of the UN Charter in 1945, or with the brutal Russian aggression against Ukraine. That said, by reviewing the changes to neutrality law over time, this article finds plausible reasons to believe that neutrality has – for better or worse – become optional for the vast majority of States, which can today opt to be non-belligerent States – i.e., States that are neither neutral nor parties to the armed conflict. All States have to cooperate to bring to an end serious violations of international law, including humanitarian law, and this duty of cooperation has abolished “sitting-still neutrality”, but it does not render neutrality law moot. This reading of “optional but not qualified” neutrality maintains the core neutrality idea of abstaining in military matters. In this article, I argue that views of “obsolete” or “qualified” neutrality are not new at all but depart from well-accepted rules of legal interpretation and raise concerns about double standards. Viewing neutrality as optional but unqualifiable offers greater conceptual clarity, is more honest than alternative views, and comes with advantages for humanitarian action.
Sphalerite Records Cd Isotopic Signatures of the Parent Rocks in Hydrothermal Systems: A Case Study From the Nayongzhi Zn–Pb Deposit, Southwest China
Authors: Song Wenrui , Zhu Chuanwei , Wen Hanjie , Huang Zhilong , Wei Chen , Zhang Yuxu , Zhou Zhengbing , Yang Zhen , Chen Xiaocui , Luais Béatrice , Cloquet Christophe
Published: May 2024

Metal stable isotopes (e.g., Zn, Cd, and Cu) have been used to track metal sources in different types of hydrothermal systems. However, metal isotopic variations in sulphides could be triggered by various factors such as mineral precipitation and fluid mixing. Thus, tracking the metal sources of hydrothermal systems is still a big challenge for metal isotopes. In this study, we investigated the Cd isotopic systematics of sphalerite from the Nayongzhi Zn–Pb deposit, which is a Mississippi Valley‐type (MVT) deposit in the Sichuan–Yunnan–Guizhou mineralization province (SYGMP). We reinterpreted the published S isotope data for the SYGMP and found that the large S isotopic variations were controlled by Rayleigh fractionation between sulphide and reduced S. As such, a model that involves mixing of a metal‐rich fluid with a reduced S pool formed by thermochemical sulfate reduction (TSR) can explain the ore formation in the Nayongzhi deposit. Based on this model, no Cd isotopic fractionation was observed due to its low solubility in fluids during mixing, and thus the Cd isotopic variations of sphalerite were inherited from the source rocks. The large range of Zn/Cd ratios and uniform Cd isotopic compositions of the sulphides are similar to those of igneous rocks but different from those of sedimentary rocks, indicating that Zn and Cd were derived mainly from basement rocks (e.g., migmatite, gneiss, and granulite). Our results reaffirm that metal stable isotopes, particularly Cd isotope compositions of sphalerite, are powerful geochemical tracers for investigating the formation mechanisms of ore deposits.
Planetary Paleomagnetic Intensity Recording Fidelity Test Using a Synthetic Lava
Authors: Wen Chen , Wang Huapei , Chou Yu‐Min , Wang Chun‐Chieh , Chen Xiaowei , Han Fei , Miao Junxiang , Ma Yiming , Liu Jiabo , Karson Jeffrey A.
Published: May 2024

Meteorite paleomagnetism is fundamental to understanding planetary dynamo processes and the evolution of the early Solar System. However, due to the extraterrestrial and ancient origins of meteorites, their paleomagnetic recording fidelity remains uncertain, which can be tested from a planetary sample formed in a known field. On Earth, historic lavas are used to examine paleomagnetic recording fidelity through the Thellier‐series experiment and other paleointensity methods, which can produce paleointensity estimates to test against the known field strength. But natural terrestrial rocks have different magnetic mineralogy from planetary samples, so they cannot faithfully infer the recording fidelity of meteorites. Here, we used an iron‐particle‐bearing sample from the Syracuse University Lava Project (SULP), which is analogous to the lunar basalts and howardite‐eucrite‐diogenite meteorites and forms in the present‐day Earth's field, to investigate the recording fidelity of these meteorites. No remanence has been identified in the high coercivity range with alternating field (AF) demagnetization due to the sample's low coercivity and AF noise, which produces underestimated paleointensities. Two accurate thermal paleointensities indicate that we may acquire accurate paleointensities from non‐ideal multidomain (MD) iron grains with the Thellier‐Coe and RESET methods, but the success rate is low due to the MD effect and thermal alteration in the experiments. Our results imply that MD iron‐bearing meteorites have the potential to provide accurate paleointensities that can be used to constrain planetary processes.
A Scaling Relation for Core Heating by Giant Impacts and Implications for Dynamo Onset
Authors: Zhou You , Driscoll Peter E. , Zhang Mingming , Reinhardt Christian , Meier Thomas
Published: May 2024

Accretional heating of Earth's interior during formation is pivotal to its subsequent thermal and chemical evolution. In particular, impact heating of Earth's core is expected, but its amplitude and radial distribution within the core is unknown and could influence the onset of the geodynamo. The uncertainty is due, in part, to the lack of constraints on the temperature of the interior following formation due to the difficulty of preserving a record of such a high energy environment, and the assertion that super‐heating during formation would be rapidly lost through magma ocean cooling. Here we systematically investigate core heating due to giant impacts using a Smoothed Particle Hydrodynamics (SPH) code with simulations spanning a range of impact angles, velocities, and masses. From these simulations we derive a scaling relation for core heating that depends on the impact parameters and predicts the radial core temperature profile following the impact. Our findings show that a significant amount of heat is deposited into the core, with a canonical impact scenario resulting in an average core temperature increase of about 3000 K, approximately 500 K higher than that of the overlying mantle. In this case the heat distribution within the core produces a strong thermal stratification. We use a parameterized cooling model to estimate that the core could have cooled to an adiabatic state ∼290 Myr after a canonical impact, which is consistent with the observed time span between the age of the Moon and evidence for an active geodynamo.
Predicting iatrogenic adrenal insufficiency in neonates exposed to prolonged steroid courses: do cortisol levels help?
Authors: Rosano Kristen , Bery Saya , Marasch Jaime , Farrell Ryan , Mastrandrea Lucy D. , Ryan Rita M.
Published: May 2024

Objective

To determine whether random cortisol levels obtained in neonates to assess for secondary adrenal insufficiency (AI) after prolonged steroid exposure are predictive of central AI.

Study design

Data were collected on neonates born 2017–2022 who received ≥10 consecutive days of systemic steroids and had cortisol measured thereafter. Data were then collected on whether those neonates developed signs of AI or had a failed adrenocorticotropic hormone (ACTH) stimulation test.

Results

Of the 71 cortisol levels (in 67 neonates) that were analyzed, there was no difference in cortisol levels between neonates who developed AI (median cortisol level of 6.5 mcg/dl) and those who did not (median of 9.2 mcg/dl), or between those who failed their ACTH stimulation test or passed it, using Wilcoxon ranked sum tests.

Conclusion

These findings demonstrate that cortisol levels may not be helpful in identifying AI in neonates exposed to prolonged steroids.
Measurement of diamine oxidase (DAO) during low-histamine or ordinary diet in patients with histamine intolerance
Authors: Rentzos Georgios , Weisheit Adina , Ekerljung Linda , van Odijk Jenny
Published: May 2024

Background/Objectives

Quantification of diamine oxidase (DAO) concentrations in serum has been proposed as an adjunctive diagnostic modality for the evaluation of histamine intolerance (HIT). Limited empirical data exist concerning the influence of dietary patterns on DAO levels.

Subjects/Methods

In the context of a prospective study employing a crossover design, 18 individuals diagnosed with HIT were randomized to initiate either a low histamine diet (LHD) or a conventional mixed diet (MXD). Serum DAO concentrations were measured at the commencement of the study and following each dietary phase. A control group underwent analogous DAO assessments without imposition of dietary constraints.

Results

During the time when a diet restricted in histamine was implemented, noticeable differences in changes in DAO levels did not become apparent when compared to the changes observed during the mixed (MXD) phase. Specifically, among the group, 10 of the 18 patients exhibited elevated DAO values subsequent to the LHD regimen, while the remaining eight displayed either reduced or unchanging DAO levels. The prevalence of elevated DAO levels in the LHD group did not differ significantly from that observed in the control group during the MXD phase. Additionally, during the LHD phase, patients reported a significant reduction in gastrointestinal and cutaneous symptoms.

Conclusions

This prospective investigation underscores the enduring utility of a histamine-restricted diet, coupled with structured dietary reintroduction, as an efficacious diagnostic approach for individuals presenting with suspected food-related histamine hypersensitivity. Notably, the measurement of DAO levels appears to furnish only a limited capacity to discern dietary-induced fluctuations. Notwithstanding, the dynamics of DAO alteration do not appear to exhibit a discernible association with specific dietary patterns, a finding consistent across both patient and control groups.
Preoperative blood urea nitrogen-to-serum albumin ratio for prediction of in-hospital mortality in patients who underwent emergency surgery for acute type A aortic dissection
Authors: Wu Qingsong , Zheng Jian , Lin Jianling , Xie Linfeng , Tang Mirong , Ke Meng , Chen Liangwan
Published: May 2024

The study aimed to assess the predictive value of blood urea nitrogen (BUN)-to-albumin ratio (BA-R) for in-hospital mortality in patients undergoing emergency surgery for acute type A aortic dissection (ATAAD). Patients who were diagnosed with ATAAD and underwent emergency surgery within 48 hours of onset at our hospital between January 2015 and December 2021 were included in this study. The primary endpoint of this study was postoperative in-hospital mortality (POIM). The data of the survivors and non-survivors were retrospectively compared analyses. A total of 557 ATAAD patients were included, with 505 survivors and 52 non-survivors. The preoperative BA-R of the non-survivor group was significantly higher than that of the survivor group (P < 0.001). Univariate regression analysis showed that preoperative BA-R, serum creatinine level, SA level, D-dimer level, age, myocardial ischemia, cerebral ischemia, and aortic clamp time were risk factors for POIM. In addition, multivariable regression analysis showed that preoperative BA-R ≥ 0.155 mmol/g was a risk factor for POIM (odds ratio, 6.815 [3.582–12.964]; P < 0.001). Receiver operating characteristic curve indicated that the cut-off point for preoperative BA-R was ≥0.155 mmol/g (area under the curve =0.874). The sensitivity and specificity of preoperative BA-R in predicting the POIM of patients who underwent emergency surgery for ATAAD were 84.6% and 71.3%, respectively (95% confidence interval, 0.829–0.919; P < 0.001). In conclusion, Preoperative BA-R is a simple, rapid, and potentially useful prognostic indicator of POIM in patients with ATAAD.
Development of a long noncoding RNA-based machine learning model to predict COVID-19 in-hospital mortality
Authors: Devaux Yvan , Zhang Lu , Lumley Andrew I. , Karaduzovic-Hadziabdic Kanita , Mooser Vincent , Rousseau Simon , Shoaib Muhammad , Satagopam Venkata , Adilovic Muhamed , Srivastava Prashant Kumar , Emanueli Costanza , Martelli Fabio , Greco Simona , Badimon Lina , Padro Teresa , Lustrek Mitja , Scholz Markus , Rosolowski Maciej , Jordan Marko , Brandenburger Timo , Benczik Bettina , Agg Bence , Ferdinandy Peter , Vehreschild Jörg Janne , Lorenz-Depiereux Bettina , Dörr Marcus , Witzke Oliver , Sanchez Gabriel , Kul Seval , Baker Andy H. , Fagherazzi Guy , Ollert Markus , Wereski Ryan , Mills Nicholas L. , Firat Hüseyin
Published: May 2024

Tools for predicting COVID-19 outcomes enable personalized healthcare, potentially easing the disease burden. This collaborative study by 15 institutions across Europe aimed to develop a machine learning model for predicting the risk of in-hospital mortality post-SARS-CoV-2 infection. Blood samples and clinical data from 1286 COVID-19 patients collected from 2020 to 2023 across four cohorts in Europe and Canada were analyzed, with 2906 long non-coding RNAs profiled using targeted sequencing. From a discovery cohort combining three European cohorts and 804 patients, age and the long non-coding RNA LEF1-AS1 were identified as predictive features, yielding an AUC of 0.83 (95% CI 0.82–0.84) and a balanced accuracy of 0.78 (95% CI 0.77–0.79) with a feedforward neural network classifier. Validation in an independent Canadian cohort of 482 patients showed consistent performance. Cox regression analysis indicated that higher levels of LEF1-AS1 correlated with reduced mortality risk (age-adjusted hazard ratio 0.54, 95% CI 0.40–0.74). Quantitative PCR validated LEF1-AS1’s adaptability to be measured in hospital settings. Here, we demonstrate a promising predictive model for enhancing COVID-19 patient management.
Revealing trends and persistent cycles of non-autonomous systems with autonomous operator-theoretic techniques
Authors: Froyland Gary , Giannakis Dimitrios , Luna Edoardo , Slawinska Joanna
Published: May 2024

An important problem in modern applied science is to characterize the behavior of systems with complex internal dynamics subjected to external forcings. Many existing approaches rely on ensembles to generate information from the external forcings, making them unsuitable to study natural systems where only a single realization is observed. A prominent example is climate dynamics, where an objective identification of signals in the observational record attributable to natural variability and climate change is crucial for making climate projections for the coming decades. Here, we show that operator-theoretic techniques previously developed to identify slowly decorrelating observables of autonomous dynamical systems provide a powerful means for identifying nonlinear trends and persistent cycles of non-autonomous systems using data from a single trajectory of the system. We apply our framework to real-world examples from climate dynamics: Variability of sea surface temperature over the industrial era and the mid-Pleistocene transition of Quaternary glaciation cycles.
Fatal COVID-19 pulmonary disease involves ferroptosis
Authors: Qiu Baiyu , Zandkarimi Fereshteh , Saqi Anjali , Castagna Candace , Tan Hui , Sekulic Miroslav , Miorin Lisa , Hibshoosh Hanina , Toyokuni Shinya , Uchida Koji , Stockwell Brent R.
Published: May 2024

SARS-CoV-2 infection causes severe pulmonary manifestations, with poorly understood mechanisms and limited treatment options. Hyperferritinemia and disrupted lung iron homeostasis in COVID-19 patients imply that ferroptosis, an iron-dependent cell death, may occur. Immunostaining and lipidomic analysis in COVID-19 lung autopsies reveal increases in ferroptosis markers, including transferrin receptor 1 and malondialdehyde accumulation in fatal cases. COVID-19 lungs display dysregulation of lipids involved in metabolism and ferroptosis. We find increased ferritin light chain associated with severe COVID-19 lung pathology. Iron overload promotes ferroptosis in both primary cells and cancerous lung epithelial cells. In addition, ferroptosis markers strongly correlate with lung injury severity in a COVID-19 lung disease model using male Syrian hamsters. These results reveal a role for ferroptosis in COVID-19 pulmonary disease; pharmacological ferroptosis inhibition may serve as an adjuvant therapy to prevent lung damage during SARS-CoV-2 infection.
Bounds to electron spin qubit variability for scalable CMOS architectures
Authors: Cifuentes Jesús D. , Tanttu Tuomo , Gilbert Will , Huang Jonathan Y. , Vahapoglu Ensar , Leon Ross C. C. , Serrano Santiago , Otter Dennis , Dunmore Daniel , Mai Philip Y. , Schlattner Frédéric , Feng MengKe , Itoh Kohei , Abrosimov Nikolay , Pohl Hans-Joachim , Thewalt Michael , Laucht Arne , Yang Chih Hwan , Escott Christopher C. , Lim Wee Han , Hudson Fay E. , Rahman Rajib , Dzurak Andrew S. , Saraiva Andre
Published: May 2024

Spins of electrons in silicon MOS quantum dots combine exquisite quantum properties and scalable fabrication. In the age of quantum technology, however, the metrics that crowned Si/SiO2 as the microelectronics standard need to be reassessed with respect to their impact upon qubit performance. We chart spin qubit variability due to the unavoidable atomic-scale roughness of the Si/SiO2 interface, compiling experiments across 12 devices, and develop theoretical tools to analyse these results. Atomistic tight binding and path integral Monte Carlo methods are adapted to describe fluctuations in devices with millions of atoms by directly analysing their wavefunctions and electron paths instead of their energy spectra. We correlate the effect of roughness with the variability in qubit position, deformation, valley splitting, valley phase, spin-orbit coupling and exchange coupling. These variabilities are found to be bounded, and they lie within the tolerances for scalable architectures for quantum computing as long as robust control methods are incorporated.
Inflammatory and neurodegenerative serum protein biomarkers increase sensitivity to detect clinical and radiographic disease activity in multiple sclerosis
Authors: Chitnis Tanuja , Qureshi Ferhan , Gehman Victor M. , Becich Michael , Bove Riley , Cree Bruce A. C. , Gomez Refujia , Hauser Stephen L. , Henry Roland G. , Katrib Amal , Lokhande Hrishikesh , Paul Anu , Caillier Stacy J. , Santaniello Adam , Sattarnezhad Neda , Saxena Shrishti , Weiner Howard , Yano Hajime , Baranzini Sergio E.
Published: May 2024

The multifaceted nature of multiple sclerosis requires quantitative biomarkers that can provide insights related to diverse physiological pathways. To this end, proteomic analysis of deeply-phenotyped serum samples, biological pathway modeling, and network analysis were performed to elucidate inflammatory and neurodegenerative processes, identifying sensitive biomarkers of multiple sclerosis disease activity. Here, we evaluated the concentrations of > 1400 serum proteins in 630 samples from three multiple sclerosis cohorts for association with clinical and radiographic new disease activity. Twenty proteins were associated with increased clinical and radiographic multiple sclerosis disease activity for inclusion in a custom assay panel. Serum neurofilament light chain showed the strongest univariate correlation with gadolinium lesion activity, clinical relapse status, and annualized relapse rate. Multivariate modeling outperformed univariate for all endpoints. A comprehensive biomarker panel including the twenty proteins identified in this study could serve to characterize disease activity for a patient with multiple sclerosis.
Placing engineering in the earthquake response and the survival chain
Authors: Ceferino Luis , Merino Yvonne , Pizarro Sebastián , Moya Luis , Ozturk Baturalp
Published: May 2024

Earthquakes injure millions and simultaneously disrupt the infrastructure to protect them. This perspective argues that the current post-disaster investigation paradigm is insufficient to protect communities’ health effectively. We propose the Earthquake Survival Chain as a framework to change the current engineering focus on infrastructure to health. This framework highlights four converging research opportunities to advance understanding of earthquake injuries, search and rescue, patient mobilizations, and medical treatment. We offer an interdisciplinary research agenda in engineering and health sciences, including artificial intelligence and virtual reality, to protect health and life from earthquakes.
A warm Neptune’s methane reveals core mass and vigorous atmospheric mixing
Authors: Sing David K. , Rustamkulov Zafar , Thorngren Daniel P. , Barstow Joanna K. , Tremblin Pascal , Alves de Oliveira Catarina , Beck Tracy L. , Birkmann Stephan M. , Challener Ryan C. , Crouzet Nicolas , Espinoza Néstor , Ferruit Pierre , Giardino Giovanna , Gressier Amélie , Lee Elspeth K. H. , Lewis Nikole K. , Maiolino Roberto , Manjavacas Elena , Rauscher Bernard J. , Sirianni Marco , Valenti Jeff A.
Published: May 2024

Observations of transiting gas giant exoplanets have revealed a pervasive depletion of methane1–4, which has only recently been identified atmospherically5,6. The depletion is thought to be maintained by disequilibrium processes such as photochemistry or mixing from a hotter interior7–9. However, the interiors are largely unconstrained along with the vertical mixing strength and only upper limits on the CH4 depletion have been available. The warm Neptune WASP-107b stands out among exoplanets with an unusually low density, reported low core mass10, and temperatures amenable to CH4, though previous observations have yet to find the molecule2,4. Here we present a JWST-NIRSpec transmission spectrum of WASP-107b that shows features from both SO2 and CH4 along with H2O, CO2, and CO. We detect methane with 4.2σ significance at an abundance of 1.0 ± 0.5 ppm, which is depleted by 3 orders of magnitude relative to equilibrium expectations. Our results are highly constraining for the atmosphere and interior, which indicate the envelope has a super-solar metallicity of 43 ± 8 × solar, a hot interior with an intrinsic temperature of Tint = 460 ± 40 K, and vigorous vertical mixing which depletes CH4 with a diffusion coefficient of Kzz = 1011.6±0.1 cm2 s−1. Photochemistry has a negligible effect on the CH4 abundance but is needed to account for the SO2. We infer a core mass of $${11.5}_{-3.6}^{+3.0}{M}_{\oplus }$$

11.5

−
3.6

+
3.0

M

⊕

, which is much higher than previous upper limits10, releasing a tension with core-accretion models11.
Analysis of gene expression in the postmortem brain of neurotypical Black Americans reveals contributions of genetic ancestry
Authors: Benjamin Kynon J. M. , Chen Qiang , Eagles Nicholas J. , Huuki-Myers Louise A. , Collado-Torres Leonardo , Stolz Joshua M. , Pertea Geo , Shin Joo Heon , Paquola Apuã C. M. , Hyde Thomas M. , Kleinman Joel E. , Jaffe Andrew E. , Han Shizhong , Weinberger Daniel R.
Published: May 2024

Ancestral differences in genomic variation affect the regulation of gene expression; however, most gene expression studies have been limited to European ancestry samples or adjusted to identify ancestry-independent associations. Here, we instead examined the impact of genetic ancestry on gene expression and DNA methylation in the postmortem brain tissue of admixed Black American neurotypical individuals to identify ancestry-dependent and ancestry-independent contributions. Ancestry-associated differentially expressed genes (DEGs), transcripts and gene networks, while notably not implicating neurons, are enriched for genes related to the immune response and vascular tissue and explain up to 26% of heritability for ischemic stroke, 27% of heritability for Parkinson disease and 30% of heritability for Alzheimer’s disease. Ancestry-associated DEGs also show general enrichment for the heritability of diverse immune-related traits but depletion for psychiatric-related traits. We also compared Black and non-Hispanic white Americans, confirming most ancestry-associated DEGs. Our results delineate the extent to which genetic ancestry affects differences in gene expression in the human brain and the implications for brain illness risk.
Study on the compounding optimization of surfactants and synergistic effects on the wettability of bituminous coal
Authors: Jing Deji , Bao Chunhua , Dong Zhe , Meng Xiangxi , Han Xuefeng , Li Gang , Chen Jingxu
Published: May 2024

To improve the wettability of surfactants on bituminous coal and to explore its wettability and wettability mechanism on bituminous coal, taking the Sandaogou bituminous coal as an example, a single factor experiment was carried out first. Through contact angle and surface tension experiments, three surfactants with good wettability were selected from among the nine surfactants and mixed in equal proportions two by two to determine the optimal compounding method and compounding concentration. The experimental results show that the compounding of nonionic and anionic, nonionic and zwitterionic, anionic and zwitterionic surfactants can have synergistic effects and significantly improve the wettability of bituminous coal. Among them, the 0.5 wt% SDS + 0.5 wt% CAB-50 (R2) compound surfactant had the best wettability on bituminous coal, and the contact angle and surface tension were only 15.24° and 23.62 mN/m, respectively. The surface electrostatic potential values of each material molecule were calculated by Materials Studio software based on the quantum chemistry method, and correlation analysis was carried out with wettability. The results show that the surface electrostatic potentials of CDEA, SDS and CAB-50 were greater than those of water and bituminous coal, and the region of maximum negative electrostatic potential corresponded to oxygen atoms, which are easier to adsorb on bituminous coal and water molecules. Then, through molecular dynamics simulation, the interaction energy and the distribution of contributions along the Z-axis of the water/compound surfactant/bituminous coal system at equilibrium were investigated, and finally, a spray dust reduction test was carried out in the Sandaogou Coal Mine. The results showed that the 0.5 wt% SDS + 0.5 wt% CAB-50 compound solution can be used as a water molecule adsorption carrier, prompting more water molecules to be embedded into coal molecules, increasing the relative concentration of water molecules on the surface of bituminous coal, restricting the diffusion of water molecules, and greatly improving the wettability. After the addition of 0.5 wt% SDS + 0.5 wt% CAB-50 as a spray agent, the concentration of total dust at the driver's position decreased from 65.14 to 9.11 mg/m3, the concentration of exhaled dust decreased from 30.07 to 3.35 mg/m3, and the efficiency of total and exhaled dust reduction compared with that of pure water was 86.01% and 89.35%, respectively.
Construction and optimization of non-parametric analysis model for meter coefficients via back propagation neural network
Authors: Yang Yuqiang , Hu Ruoyun , Wang Weifeng , Zhang Tuomu
Published: May 2024

This study addresses the drawbacks of traditional methods used in meter coefficient analysis, which are low accuracy and long processing time. A new method based on non-parametric analysis using the Back Propagation (BP) neural network is proposed to overcome these limitations. The study explores the classification and pattern recognition capabilities of the BP neural network by analyzing its non-parametric model and optimization methods. For model construction, the study uses the United Kingdom Domestic Appliance-Level Electricity dataset’s meter readings and related data for training and testing the proposed model. The non-parametric analysis model is used for data pre-processing, feature extraction, and normalization to obtain the training and testing datasets. Experimental tests compare the proposed non-parametric analysis model based on the BP neural network with the traditional Least Squares Method (LSM). The results demonstrate that the proposed model significantly improves the accuracy indicators such as mean absolute error (MAE) and mean relative error (MRE) when compared with the LSM method. The proposed model achieves an MAE of 0.025 and an MRE of 1.32% in the testing dataset, while the LSM method has an MAE of 0.043 and an MRE of 2.56% in the same dataset. Therefore, the proposed non-parametric analysis model based on the BP neural network can achieve higher accuracy in meter coefficient analysis when compared with the traditional LSM method. This study provides a novel non-parametric analysis method with practical reference value for the electricity industry in energy metering and load forecasting.
Stratified water columns: homogenization and interface evolution
Authors: Liu Mengwei , Park Junghee , Santamarina J. Carlos
Published: May 2024

Stratified water columns are often found in lakes and oceans. Stratifications result from differences in density due to salt concentration, temperature, solid content and oxygenation. The stability of stratifications affects bioactivity, sedimentation, contaminant transport and environmental remediation. This study investigates the evolution of 6 stratified water columns created by differences in salinity, suspended minerals and the presence of a bottom heat source. We use acoustic wave reflection, photography, and both electrical conductivity and temperature profiles to track changes in stratification. Results show that multiple concurrent processes emerge across layers in otherwise quiescent water bodies. Dissimilar chemo-thermo conditions give rise to chemical and thermal diffusion, convection, and double-diffusion convection. When stratification involves suspended particles, interlayer processes include diffusiophoresis, flocculation/aggregation, sedimentation, osmosis, and chemo-consolidation; in this case, the specific surface and surface charge of suspended particles, and the salt concentration in contiguous layers determine aggregation-sedimentation-consolidation patterns. The interlayer transition zone acts as a high-pass filter that preferentially reflects low-frequency long-wavelength P-waves; invasive thermal and electrical conductivity probes provide complementary information and may identify stratification even when it is undetected by acoustic signals.
“Secular trends (2001–2020) in physical fitness as a health component in physiotherapy students from Bydgoszcz (Poland)”
Authors: Lewandowski Andrzej , Siedlaczek Marcin , Piekorz Zuzanna , Kryst Łukasz
Published: May 2024

The aim of this study was to assess changes in the components of physical fitness that are conducive to the health of young people surveyed between 2001 and 2020. Hypotheses were formulated about an increase in the thickness of skinfolds, especially among women, the deterioration of the results of fitness tests and the lack of conditioning of the examined changes with socioeconomic factors. Every year, physiotherapy students at the Collegium Medicum in Bydgoszcz, Nicolaus Copernicus University in Toruń (Poland) were examined for body height and mass, skinfold thickness, flexibility, static strength, abdominal muscle strength, functional strength and endurance. The results were obtained from 1161 female students and 464 male students. Similar trends were observed for most of the studied characteristics in people of both sexes. In male students, secular trends towards a decrease in the thickness of biceps skinfolds (R2 = 0.455, p = 0.002) and lower leg skinfolds (R2 = 0.314, p = 0.015) were found. In female students, secular trends towards an increase in the body mass (R2 = 0.41, p = 0.003), a decrease in the thickness of skinfolds over the biceps (R2 = 0.477, p = 0.001) and decreased flexibility (R2 = 0.283, p = 0.023) were found. Male sex and the thickness of suprailiac skinfolds were frequent predictors of the, assessed motor abilities and socioeconomic factors did not significantly affect their maintenance. The obtained results, except for a few secular trend examples of the somatic features (male student’s age and calf skinfold, female student’s body mass, male and female student’s biceps skinfold) and flexibility in women, showed their stability and the lack of conditioning by social factors and by the fitness test. Attention to the appropriate level of the observed components is justified, especially in light of the identified trend that showed their deterioration.
Material strengths of shear-induced platelet aggregation clots and coagulation clots
Authors: Kim Dongjune A. , Ku David N.
Published: May 2024

Arterial occlusion by thrombosis is the immediate cause of some strokes, heart attacks, and peripheral artery disease. Most prior studies assume that coagulation creates the thrombus. However, a contradiction arises as whole blood (WB) clots from coagulation are too weak to stop arterial blood pressures (> 150 mmHg). We measure the material mechanical properties of elasticity and ultimate strength for Shear-Induced Platelet Aggregation (SIPA) type clots, that form under stenotic arterial hemodynamics in comparison with coagulation clots. The ultimate strength of SIPA clots averaged 4.6 ± 1.3 kPa, while WB coagulation clots had a strength of 0.63 ± 0.3 kPa (p < 0.05). The elastic modulus of SIPA clots was 3.8 ± 1.5 kPa at 1 Hz and 0.5 mm displacement, or 2.8 times higher than WB coagulation clots (1.3 ± 1.2 kPa, p < 0.0001). This study shows that the SIPA thrombi, formed quickly under high shear hemodynamics, is seven-fold stronger and three-fold stiffer compared to WB coagulation clots. A force balance calculation shows a SIPA clot has the strength to resist arterial pressure with a short length of less than 2 mm, consistent with coronary pathology.
Migratory movements of fin whales from the Gulf of St. Lawrence challenge our understanding of the Northwest Atlantic stock structure
Authors: Ramp Christian , Lesage Veronique , Ollier Angélique , Auger-Méthé Marie , Sears Richard
Published: May 2024

Fin whales, Balenoptera physalus, are capital breeders, having the potential to separate breeding and feeding both spatially and temporally. Fin whales occur throughout the Northwest Atlantic, but stock structure and seasonal movements remain unclear. By deploying satellite transmitters on 28 individuals, we examine movement patterns within and beyond the Gulf of St. Lawrence (GSL), Canada, and challenge the current understanding of stock structure. Eight individuals left the GSL in autumn, with five tags persisting into January. Migration patterns of these whales showed considerable variation in timing and trajectory, with movements extending south to 24°N, and thus beyond the assumed distribution limit of the species in the Northwest Atlantic. A rapid return to the Scotian Shelf or Gulf of Maine was observed from several whales after incursions in southern waters, suggesting that fin whales in the Northwest Atlantic may not have a common winter destination that fits the definition of a breeding ground. Area-restricted search (ARS) behavior dominated fin whale activities during summer (92%) and fall (72%), with persistence into the winter (56%); ARS occurred at multiple locations in the GSL, Scotian Shelf and Shelf edge, and near seamounts of the North Atlantic, having characteristics consistent with foraging areas.
Toward a push–pull strategy against invasive snails using chemical and visual stimuli
Authors: Kosciolek Cédric , Desurmont Gaylord A. , Thomann Thierry , Zamprogna Alberto , Caron Valérie
Published: May 2024

Four invasive Mediterranean snails, i.e., Theba pisana (Müller, 1774), Cernuella virgata (da Costa, 1778), Cochlicella acuta (Müller, 1774) and Cochlicella barbara (Linnaeus, 1758) cost $170 million yearly to the grain industry in Australia. Their impact is mainly due to their estivation behavior: snails climb on cereal and legume stalks to rest during summer, which coincides with harvest, causing grain contamination issues in crops such as wheat, barley and canola. Diverse management methods have been developed to regulate snail populations, with limited success. Our study investigates the potential for a push–pull strategy to divert invasive snails from cultivated fields. A “push” part (i.e. using a repellent stimuli) was based on the use of a chemical deterrent repelling snails from the cultivated field, and a “pull” part (i.e. using an attractive stimuli) was based on offering attractive estivation supports for snails to aggregate outside the cultivated field. First, artificial estivation supports of different colors were tested under laboratory and field conditions and showed that red supports were the most attractive for these snails. Second, different substances were tested as potential snail deterrents (garlic, coffee, coffee grounds, copper). Garlic extracts were the most powerful snail deterrent and were shown to effectively protect an estivation support and food source from snails under laboratory conditions. These results, which were highly consistent for the four species, illustrate the potential of a push–pull strategy against invasive snails in Australia. It is the first attempt to develop a push–pull strategy relying on both visual and chemical stimuli to achieve results, as well as manipulating the estivation behavior of a pest.