bluuebunny/crossref_metadata_2025 huggingface dataset:
The conformity between dermoscopy imaging and Wood’s lamp diagnostic on periorbital hyperpigmentation
Authors: Samsul Cut Samira , Putra Imam Budi , Jusuf Nelva Karmila
Published: February 2022

Introduction: Periorbital hyperpigmentation (POH) is a common skin problem characterized by homogeneous/dark brown hyperchromic/pigmented macules around the lower eyelid and upper eyelid up to the malar area temporal area and the sides of the nose. POH is a multifactorial condition caused by both endogenous factors and exogenous factors, without one aspect dominating. Dermoscopy and Wood's lamp can assist the diagnosis of POH types when the inspection is regarded as weak. The assessment of the suitability of the dermoscopic image and Woods’ lamp diagnosis indicates an alternative supporting test in POH diagnosis. This study aimed to examine the conformity between dermoscopic images and Wood's lamp examination in POH diagnosis.Methods: This observational conformity study was conducted using a cross-sectional design. There were 38 subjects diagnosed with POH who went to the Cosmetics Division of Dermatology and Venereology, Universitas Sumatra Utara Hospital participated as subjects. Assessments regarded the types of POH analyzed based on dermoscopic images and Wood's lamp examination. Data analysed with SPSS version 20 using Kappa test.Results: On dermoscopy examination, the mixed type was the type most obtained, as many as 18 subjects (47,4%), whilst on Wood's lamp examination, the most dominant type obtained was pigment type, as much as 21 subjects (55,3%). Moderate conformity value on POH examination was obtained with dermoscopy and Wood’s lamp.Conclusion: Dermoscopic images and Wood's lamp examination shared a sufficient conformity value in POH diagnosis.
Comparison of the sacral ratio between children with Hirschsprung disease and non-Hirschsprung
Authors: Nugraha Harry Galuh , Miranti Pramesti Indri
Published: February 2022

Background: Hirschsprung's disease is a congenital gastrointestinal disorder that is the most common cause of intestinal obstruction in children. One of the factors that influence gastrointestinal disorders is the sacrum bone. The sacral index can review the evaluation of the sacral bone, an instrument that can evaluate the development of the sacral bone in different clinical conditions. This study assessed the value of the sacral ratio in children with Hirschsprung's disease and non-Hirschsprung's disease at Dr. Hospital. Hasan Sadikin Bandung.Methods: This study was a descriptive-analytic study with a case-control design. Sampling was done retrospectively by collecting medical record data and the enema barium readings from October 2019 to July 2020. The study was conducted at the Department of Radiology Hospital Dr. Hasan Sadikin Bandung from September to October 2020. Data processing uses an unpaired T-test.Results: The total sample was 58 objects, consisting of 29 with Hirschsprung’s disease and 29 non-Hirschsprung, with an average age of Hirschsprung’s disease was 3.14±3.905 years. In the Hirschsprung’s disease group, the mean sacral ratio value was 0,62 and, and the mean sacral ratio in the non-Hirschsprung group was 0,74. Statistical test results with unpaired T-test showed significant mean differences in the case and control groups (p=0.0001).Conclusion: The sacral ratio value in children with Hirschsprung’s disease compared to non-Hirschsprung were different significantly.
The Comparison of intravesical hyaluronic acid and other modalities for the improvement of interstitial cystitis symptoms: a systematic reviews and meta-analysis
Authors: Ariwicaksono St Cahyo , Rahardjo Harrina Erlianti
Published: February 2022

Background: Interstitial cystitis (IC) is a chronic inflammation of the bladder which causes unpleasant sensations. This condition considerably reduces patients' quality of life. Intravesical hyaluronic acid is one of the new interventions for interstitial cystitis management, in which a thorough review and meta-analysis regarding this topic are still limited. This study aimed to compare the efficacy of intravesical hyaluronic acid with other intravesical treatment modalities available to treat interstitial cystitis.Method: Systematic literature searching with the main keywords of "interstitial cystitis" or "bladder pain syndrome" and "intravesical hyaluronic acid" was conducted. The main outcome of this study was pain assessment using a visual analogue scale (VAS) and Interstitial Cystitis Symptoms Index (ICSI), and problem index (ICPI). Meta-analysis was carried out when comparative studies were available. Eleven studies were obtained to assess intravesical hyaluronic acid's effects, including three in the meta-analysis. The intravesical treatments found as a comparison were heparin and chondroitin sulphate.Result: There was significant heterogeneity among studies included in all parameters. The pooled analysis showed no significant difference in VAS reduction, improvement of ICSI and ICPI score (p = 0.11, p = 0.35, and p = 0.28, respectively) between hyaluronic acid and other intravesical treatments.Conclusion: There was no significant difference between hyaluronic acid and other intravesical treatments. However, further research with a larger sample is needed to confirm the best modalities in interstitial cystitis.
The relationship between tooth size, arch length and arch perimeter in Egyptians
Authors: Elhiny Omnia A. , Sharaf Rasha Farouk , Abou Elyazied Mohammed , Radwan Ehab , Salem Ghada A.
Published: February 2022

Aim: The present study was conducted to determine the correlation between the combined mesiodistal width of teeth, arch length and arch perimeter in a sample of the Egyptian population.Material and methods: Four hundred and twenty pairs of dental casts were traced using TracerNet. The combined mesiodistal width of teeth (CMWT), arch length (AL) and arch perimeter (AP) were measured. Statistical analysis was conducted utilizing Pearson correlation and paired t-test.Results: The results showed a significant positive correlation in the lower arch between the AP and the AL, the CMWT and AL; p<0.05. There were no significant correlations in the upper arch. There was significant difference between the ratio of the upper and lower AP to CMWT; p=0.00.Conclusions: There were positive correlations between the arch perimeter and arch length, combined mesiodistal width of teeth and the arch length in the lower arch, with no correlation between the arch perimeter and the combined mesiodistal width of teeth. Therefore, during orthodontic diagnosis and treatment planning a thought should be given to treatment options that do not involve reduction of tooth mass. The measured values of the different variables could act as a database describing the tooth width and arch dimensions of the representative sample.
Response to: Choreo-ballistic movements heralding COVID-19 induced diabetic ketoacidosis
Authors: Parwanto Edy
Published: February 2022

N/A
Functional Movement Screen (FMS) as a determinant factor to assess the risk of injuries in young athletes at Jakarta Province, Indonesia
Authors: Anthony Anthony , Pakasi Trevino Aristarkus , Kurniarobbi Jull
Published: February 2022

Background: Lower extremity injuries are the most common injuries in young athletes due to running, jumping, sudden change of movement, and contact with the other player in most of the sport’s activities. Preventive efforts are the most effective ways to decrease the risk of lower extremity injuries. Functional Movement Screen (FMS) can be considered effective ways in helping to identify risk factors in the young athlete. This study aims to evaluate the FMS as a determinant factor to assess the risk of injuries in young athletes in Jakarta Province, IndonesiaMethods: Participants were young athletes who train in Provincial Student Sports Training Center (PSSTC), South Jakarta. Athlete age less than 18 years old, agree to participate in this research and has normal physical health will be included in this research and proceed to be asked time exposure of training and history of injuries; body posture and FMS examination. Analysis bivariate dan multivariate were done to see if there is the association of seven components of FMS, sex, time exposure of training, history of injuries, body posture and lower extremity injuries. Data were analyzed using SPSS version 20 for Windows.Results: There was 87 participant that participated in this research. The data showed that ankle (36.7%), thigh (36.7%) and knee (16.0%) were the three most common lower extremity injuries. Bivariate analysis showed a significant association between hurdle step, time exposure of training, and histories of injuries with the incidence of injuries (p<0.25). Logistic regression multivariate analysis showed that history of injuries (OR=4.276; 95%CI=1.599-11.437) and time exposure of training (OR=3.470; 95%CI=1.274-9.448) had a significant association with incidence of injuries (p<0.05)Conclusions: There was no association of seven components of FMS with lower extremities injuries. However, there was a significant association of injury histories and training exposure with the incidence of injuries.
Changes in Ki67 expression and clinical response to neoadjuvant chemotherapy in locally advanced breast cancer (LABC)
Authors: Devi Desak Gede Agung Pramesti , Purwanto Heru , Sandhika Willy
Published: February 2022

Background: Locally Advanced Breast Cancer (LABC) is still the most common stage found in breast cancer patients in Indonesia. Neoadjuvant Chemotherapy (NAC) is the initial therapy and the main pillar of LABC treatment. NAC could provide less extensive surgery and improve patient’s overall survival to those who achieve a complete pathological response. Ki67 expression is a tumor biomarker representing tumor cell proliferation and has been extensively investigated as a promising predictive and prognostic factor in breast cancer. This study aims to examine the association between Ki67 expression with clinical response of NAC.Methods: The study was designed as a case-control study in breast cancer patients who received standard anthracycline-based NAC. Clinical and immunohistochemical characteristics before and after NAC were obtained retrospectively. Changes in Ki67 and NAC responses were analyzed. Data were analyzed using SPSS version 23 for WindowsResults: A total of 66 subjects were analyzed. About 33 subjects were in good clinical response and 33 subjects were in poor clinical response. Chi-square analysis showed that no significant differences were found in the pre-treatment Ki67 expression between good and poor clinical response group, whereas a low post-treatment Ki67 expression (Ki67 <20%) was correlated with a good clinical response to NAC (p=0.027). Further analysis also showed that a decrease of Ki67 expression greater than 12.5% after treatment was significantly correlated with good clinical response (p=0.007; OR=4.67; 95%CI=1.45-15.08). In multivariate analysis, a decrease in Ki67 was significantly correlated to response in NAC (p=0.037).Conclusion: Decreased in Ki67 greater than 12.5% was correlated with good clinical response of Anthracycline-based NAC in LABC.
Effects of sodium bicarbonate ingestion on prolonged running performance and recovery in trained runners
Authors: Shing Lew Ka , Yin Ler Hui , Yong Gee Yong , Hoe Wee Eng
Published: February 2022

Background: While the effects of sodium bicarbonate on buffering capacity have been repeatedly examined on short-term and high-intensity exercise performance, studies on prolonged endurance performances such as running are scarce. Thus, the purpose of this study was to investigate the effect of NaHCO? (0.3 g/kgBW) ingestion 60-minutes prior to the prolonged running testing and recovery in trained runners.Methods: A total of 10 trained male runners (age: 20.70±1.10 years; weight: 61.30±6.20 kg; height: 166.10±3.70 cm; VO2max 58.43±5.62 mL/kg/min) were recruited in this study. Subjects undertook 1 preliminary testing and 2 experimental trials: Sodium Bicarbonate (SB) and Placebo (PLA) trials, which consisted of: (i) a 60-minutes Prolonged Exercise Testing (PET) (30-minutes of constant speed run at 65 % of VO2max followed by a self-selected speed of 30-minutes maximum distance run) and (ii) 30-minutes of the recovery period in randomized order. Data were analyzed using SPSS version 23 for Windows.Results: Subjects ran further during the SB trial than the PLA trial (5,233.60±524.70 m vs. 5,021.40±440.10 m; p=0.012) associated with a greater blood lactate level (5.66±1.09 mmol/L vs. 3.68±0.71 mmol/L). Ingestion of SB drinks significantly increased urine pH during PET and recovery period (p<0.01). During post-recovery, a greater decrease in blood lactate level was found in the SB trial (2.53±0.91 mmol/L; 55%) as compared to the PLA trial (2.17±0.50 mmol/L; 41%) (p<0.01).Conclusion: The ingestion of NaHCO?(0.30 g/kgBW) 60-minutes prior to the PET improved prolonged running performance associated with a faster lactate removal rate during the 30-minutes recovery period.
Relationship between plasma atherogenic index and xanthelasma palpebrarum
Authors: Setio Wati Sri Karunia , Putra Imam Budi , Jusuf Nelva Karmila
Published: February 2022

Introduction: Xanthelasma is a common form of skin xanthoma. It is due to abnormal lipid deposition in the eyelid skin. Xanthelasma is thought to be a sign of dyslipidemia, one of the important risk factors in atherosclerosis. The risk of atherosclerotic disease can be determined using the atherogenic index of plasma (AIP) parameters. AIP is a mathematical relationship between TG and HDL in logs (TG/HDL). Thus, this study aimed to determine the relationship between the atherogenic index of plasma and xanthelasma palpebrarum at the Polyclinic of the Department of Dermatology and Venereology, Universitas Sumatera Utara Hospital.Methods: This study was an observational analytic study with a cross-sectional approach involving 50 patients with xanthelasma palpebral and 50 controls based on inclusion and exclusion criteria. Gender, age, lipid profile values (cholesterol, HDL, LDL, and triglycerides), and Atherogenic Index of Plasma (AIP) values were recorded. Laboratory tests measured assessment atherogenic index of plasma to determine triglyceride (TG) and high-density lipid (HDL) levels using the Cobas 6000 C501 device.  An independent t-test was conducted to assess the relationship between research variables, and it was declared significant with p < 0.001.Results: The majority of xanthelasma palpebrarum occurred in women (94%), and the mean value of the subjects of this disease was higher in the 50-59 year age group (42%). The mean value of lipid profile (total cholesterol, LDL, HDL, and triglycerides) in xanthelasma palpebrarum subjects tends to increase compared to subjects without xanthelasma palpebrarum. The results obtained using the logistic regression test showed that there was a significant relationship between plasma atherogenic index (AIP) values and xanthelasma palpebrarum (p < 0.001). In the group with xanthelasma palpebrarum, the highest proportion were subjects with an IAP value > 0.21 (high risk), and the risk of experiencing xanthelasma palpebrarum was 7.714 times greater than subjects with an AIP < 0.11 (low risk).Conclusion: There is a relationship between plasma atherogenic index and xanthelasma palpebrarum.
Simulation and audio-visual learning method for knowledge of cardiac pulmonary resuscitation skills in nursing students
Authors: Etlidawati Etlidawati , Milinia Khusnul
Published: February 2022

Background: The COVID-19 pandemic has disrupted human activities, one of which is education, which requires a modification of learning. Online-based audio-visual learning methods are needed to deliver material until offline learning is active again so that learning activities can still be carried out. This study aims at a simulation and audio-visual learning method on cardiac, pulmonary resuscitation skills in nursing undergraduate students.Methods: The research uses a descriptive-analytic cross sectional approach. The variables in this study are simulation learning, audio-visual and knowledge of resuscitation. The sample was 83 respondents, and the sampling technique was probability sampling utilizing proportionate stratified random sampling.Results: The results showed that most of the respondents considered both simulation and audio-visual methods learning, 56 respondents (67.5%) and 62 respondents (74.7%), considered 27 respondents (32.5%) and 21 respondents (25.3%) bad. Knowledge of good category skills were 62 respondents (74.7%), and bad were 21 respondents (25.3%). Chi-Square test results obtained p-value 0.025 <a = 0.05.Conclusions: There is a significant relationship between learning method simulation and audio-visual methods on the knowledge of cardiac, pulmonary resuscitation laboratory skills in undergraduate nursing students in the COVID-19 pandemic.
The correlation between dysfunctional family process and self-neglect of street children at Special Region of Yogyakarta
Authors: Irawati Kellyana , Ningrat Fadjri Nuryusofa , Dewi Eltanina Ulfameytalia
Published: February 2022

Introduction: Street children still become a big concern in the world, and United Nations has concerns about a homeless child or live-in poverty. Dysfunction of the family process has the worst implication for the child as a vulnerable population. It does not only increase anxiety and depression but also leads to self-neglect especially among street children. The nurse especially the mental health nurse and community nurse needs to identify the risk factor of dysfunctional family process and self-neglect to make possible prevention and intervention for street children. This study aims to determine the correlation between the dysfunction of the family process and the self-neglect of street children in Yogyakarta. Methods: The sample was 90 street children who are from the district in Yogyakarta. The sample was taken by accidental sampling technique, with the sampling criteria: 1) the street children who live in Yogyakarta, 2) willing to fill inform consent, 3) both boys or girls, 4) age 10-21 years old, 5) not marriage yet. The instrument was using a dysfunction of family process questionnaire and self-neglect questionnaire which are both are developed from NANDA-I Nursing Diagnoses. The data analysis was used Pearson Correlation Test. Results: The mean score of dysfunctions of the family process is 109 and self-neglect has a mean score of 28.33. There was a significant relationship between dysfunction of family process and self-neglect among street children in Yogyakarta (p= 0.000) with a correlation coefficient were 0.659. Conclusions: There was a significant relationship between dysfunction of family process and self-neglect among street children in Yogyakarta
COVID-19 Pandemic: Maternal Anxiety Increases During Pregnancy, Indonesia
Authors: Dewi Arlina , Junaedi Fajar , Safaria Triantoro , Supriyatiningsih Supriyatiningsih , Dewanto Iwan , Dewi Dyah Tri Kusuma
Published: February 2022

Introduction: The anxiety of pregnant women during the Covid-19 pandemic increased compared to pregnancy in ordinary conditions because pregnant women are one of the populations vulnerable to Covid-19 infection. The Covid-19 Pandemic can affect the health of pregnant women and fetuses, even feared increased morbidity and mortality. This study aimed to determine the anxiety of pregnant women, especially related to maternal and infant health in the Covid-19 pandemic.Method: This research is using a quantitative descriptive method with a cross-sectional design. The sample in this study were all pregnant women who were willing to take part in this study. Respondents came from three islands in Indonesia, namely   Java, Sulawesi and Sumatra. The sampling technique used accidental sampling; as many as 20 respondents carried out checks at health  facilities during the pandemic Covid-19. Researchers adopted the Pregnancy Stress Rating Scale (PSRS) instrument for 36 items statement and converted it in a google form for online surveys. The data analysis in this study used a frequency distribution.Results: The results showed that most of the pregnant women who experienced a severe level of anxiety in “finding safe health facilities for mothers and babies during pregnancy, and childbirth” (32.3) with a tertiary level of education (71.4), live outside the island of Java (83.3), and anxiety increased in the second trimester (61.5) and the third trimester (66.7).Conclusion: The emotional well-being of pregnant women must be maintained to produce a good quality  pregnancy outcome, so that health workers need to identify pregnant women's anxiety early to minimize its effects. In addition, pregnant women must have the self-awareness to assess  the health conditions, including anxiety during the pregnancy process.
Relationship between serum IgE levels and psoriasis area and severity index (PASI) score in psoriasis vulgaris
Authors: Hidayat Fitra Aina , Nababan Kristo Alberto , Roesyanto Irma Damayanti
Published: February 2022

Introduction: Psoriasis is an immune system-mediated inflammatory disorder characterized by skin inflammation, epidermal hyperplasia, and other comorbidities. Based on medical data from H. Adam Malik hospital in 2011, the proportion of psoriasis vulgaris incidence was 0.81%. It is important to assess the severity of the disease. The most frequently used measuring instrument is the Psoriasis Area and Severity Index (PASI) score. Elevated serum IgE levels have been reported in some cases of psoriasis. The relationship between serum IgE levels and psoriasis severity is controversial. The study aimed to determine the relationship between serum IgE levels and PASI scores in psoriasis vulgaris.Method: An observational analytic study with a cross-sectional approach to 37 subjects of psoriasis vulgaris at Haji Adam Malik General Hospital Medan. Patients who meet the criteria are recorded with basic data in personal identity, history taking, physical examination, and dermatological examination. Furthermore, the calculation of the Psoriasis Area and Severity Index (PASI) score and serum IgE levels using ARCHITECT CI8200 with Quantia IgE reagent. The data will be analyzed using SPSS.Results: Psoriasis vulgaris mostly occurs in women (54.1%) with the most age group 31-45 years (40.5%). The median age was 35 years with a range of 21-67 years. The proportion of study subjects with high serum IgE levels (?100) was 26 people (70.3%) with a median of 130 IU/ml and a range of 25-475.5 IU/ml. Based on the PASI score, the highest proportion were subjects with moderate and mild PASI scores as many as 21 people (56.8%) and 13 people (35.1%). The median PASI score was 6, with a range of 0.5 – 10.40. The results of the Pearson correlation test (p) serum IgE levels and PASI scores obtained p-value = 0.0001, which indicated that the relationship between serum IgE levels and PASI scores was significant. The value of the correlation coefficient (r) of 0.909 indicates that the direction of the positive correlation with the strength of the correlation is very strong.Conclusion: There is a relationship between serum IgE levels and Psoriasis Area and Severity Index (PASI) scores in psoriasis vulgaris.
General surgery practice in Aceh rural hospital during the COVID-19 pandemic: a descriptive cross-sectional study
Authors: Sempaty Wira Nico , MH Hasmija
Published: February 2022

Background: COVID-19 pandemic is one of the biggest issues that we have faced and has had a significant impact on healthcare practice worldwide. Increasing COVID-19 cases requires the surgical department to reorganize all the patient treatment to prevent infection. This study aims to find out the pattern of general surgery care during the COVID-19 pandemic compared to the non COVID-19 period and to know better to prepare for surgical patients' treatment in the future.Method: This is a descriptive cross-sectional study. We studied the important points of a complete range of the patient at the department of surgery outpatient, inpatient, and operation theatre of Datu Beru Hospital from 1 March 2020 to 31 December 2020 for the COVID period and 1 March 2019 to 31 December 2019 for the non-COVID period.Result: There were 2822 outpatient visits during the non-COVID period and 1949 patients during the COVID period. The total decrease in outpatient visits was 30.93% during the pandemic. Female outpatient visits are 51.25% during COVID period. There is 36.49 % reduction in total operation during pandemic. Total elective cases were 78,68% decrease over the pandemic period from 591 to 126 cases. There were 45% reduction inpatient admissions during pandemic.Conclusion: There is a reduction in number of general surgery cases during COVID-19. Some elective surgeries can still be performed with triage according to the guideline. All actions are following protocol and Personal Protection Equipment so that the safety of surgeons, staff, and patients is maintained.
The relationship of Soluble Suppression of Tumorigenicity 2 (sST2) and Troponin T (TnT) levels in Acute Myocardial Infarction (AMI) patients at Sanglah General Hospital, Bali, Indonesia
Authors: Dewi Made Minarti Witarini , Mulyantari Ni Kadek , Lestari Anak Agung Wiradewi , Prabawa I Putu Yuda
Published: February 2022

Background: Acute Myocardial Infarction (AMI) as cardiovascular disease is a significant cause of death worldwide and requires examining cardiac biomarkers such as Troponin T (TnT) for diagnosis. However, increased troponin levels are often found in non-AMI patients. Soluble Suppression of Tumorigenicity 2 (sST2) as a novel biomarker has known will increase after the occurrence of AMI. This study aims to evaluate the relationship of sST2 and TnT levels in AMI patients at Sanglah General Hospital, Bali, IndonesiaMethods: The study was conducted among 61 participants during August-December 2020 by consecutive sampling. The samples were examined for TnT levels using a Roche Cobass h232 and sST2 with the Human sST2 Elabscience© Enzyme-linked Immunosorbent Assay (ELISA) Kit. Normality and correlation tests were performed between the two parameters. Data were analyzed using SPSS version 17 for Windows.Results: The average age of participants was 59.5±10.0 years old. Most of the participants were male and had hypertension history in STEMI (71.0% and 67.7%) and NSTEMI (70.0% and 79.0%) groups. There is no significant difference in BMI between STEMI (23.5±3.1 kg/m2) and NSTEMI (24.6±3.8 kg/m2) (p=0.319). However, there was a significant moderate positive correlation between TnT and sST2 levels (r=0.394, p=0.002).Conclusion: There was an increase in troponin T and sST2 levels in AMI patients at Sanglah Hospital. There is a significant positive correlation between sST2 levels and troponin T levels in AMI patients at Sanglah Hospital.
Pansinusitis kronis dengan komplikasi abses serebri dan selulitis preseptal: laporan kasus
Authors: Maharani Iriana , Santoso David
Published: February 2022

Background: Rhinosinusitis is an inflammation of the sinuses of the paranasal mucosa, while pansinusitis is an inflammatory process in several sinuses. Rhinosinusitis is one of the most prevalent health problems in the world. Although rare, rhinosinusitis can also lead to serious complications, including intracranial complications such as a cerebral abscess. This case report attempts to evaluate a cerebral abscess and preseptal cellulitis caused by chronic pansinusitis.Case Presentation: A 56 years old woman, after trepanation, was consulted by the neurosurgery department to the ear, nose, throat, head, and neck department at dr. Saiful Anwar Hospital. Patients with complaints of decreased consciousness. A gradual decrease in consciousness was felt 3 weeks before admission to the hospital (SMRS). CT scan showed a cerebral abscess with a single lesion located in the frontal (unilocular) lobe as a complication of chronic pansinusitis. In this case, there was also preseptal cellulitis due to the spread of infection from the ethmoid sinus to the orbit. Treatment with ceftriaxone, metronidazole, omeprazole, ketorolac, Levemir, Apidra, Levocin, and anterior ethmoidectomy showed clinical improvement.Conclusion: Cerebral abscess is a rare complication of chronic pansinusitis but has a high morbidity and mortality rate. Medical intervention and anterior ethmoidectomy showed clinical improvement in patients. Latar Belakang: Rinosinusitis adalah peradangan sinus mukosa paranasal sedangkan pansinusitis merupakan proses inflamasi pada beberapa sinus. Rinosinusitis adalah salah satu masalah kesehatan yang memiliki prevalensi besar di dunia. Meskipun jarang terjadi, rinosinusitis juga dapat mengakibatkan komplikasi serius termasuk komplikasi intrakranial seperti abses serebri. Laporan kasus ini berupaya untuk mengevaluasi abses serebri dan selulitis preseptal yang disebabkan oleh pansinusitis kronis.Presentasi Kasus: Seorang wanita berusia 56 tahun pasca trepanasi dikonsultasikan oleh departemen bedah saraf ke departemen telinga hidung tenggorok kepala leher (THT-KL) RSUD dr. Saiful Anwar Pasien dengan keluhan terjadi penurunan kesadaran. Penurunan kesadaran secara gradual dirasakan semenjak 3 minggu sebelum masuk rumah sakit (SMRS). Pemeriksaan CT-Scan menunjukkan keberadaan abses serebri dengan lesi tunggal yang terletak pada lobus frontalis (unilokuler) sebagai komplikasi pansinusitis kronis. Pada kasus ini juga didapatkan selulitis preseptal akibat penyebaran infeksi dari sinus ethmoidalis ke orbita. Pengobatan dengan pemberian ceftriaxone, metronidazole, omeprazole, ketorolac, Levemir, Apidra, Levocin, dan etmoidektomi anterior menunjukkan perbaikan klinis.Kesimpulan: Abses serebri adalah komplikasi yang jarang pada pansinusitis kronis tetapi memiliki angka morbiditas dan mortalitas yang tinggi. Intervensi medikamentosa dan etmoidektomi anterior menunjukkan perbaikan klinis pada pasien.
Membedah peran bank sampah guna menilik efektivitas pengelolaan limbah medis B3 rumah sakit
Authors: Karna I Nyoman Yustra , Adi I Nyoman Rasmen
Published: February 2022

Background: The implementation of the waste bank to reduce the cost of hazardous and toxic medical waste management needs to be optimized so that it is effective to reduce costs and additional hospital income.Aim: The study aims to determine the factors causing the non-optimal management of medical waste at Surya Husadha Hospital through the implementation of the waste bank.Methods: This study applied a qualitative approach with purposive sampling at Surya Husadha Hospital. Data were collected through observation, in-depth interviews and documentation from six informants.  Result: Some obstacles cause the implementation of the waste bank at Surya Husadha Hospital in reducing medical waste management costs to be not optimal, such as limited human resources and equipment. This obstacle causes only two of the four types of medical waste according to the Regulation of the Minister of Environment and Forestry of the Republic of Indonesia No. 56 of 2015, which can be managed through waste banks such as used infusion bottles and used hemodialysis fluid packaging.Conclusion: The implementation of the waste bank at Surya Husadha Hospital has met the proper regulation, but it is necessary to evaluate the constraints, and planning for the needs of human resource and equipment in reducing medical waste management costs. Latar Belakang: Penerapan bank sampah dalam membantu beban biaya pengelolaan limbah medis bahan berbahaya dan beracun (B3) perlu lebih dioptimalkan sehingga bisa efektif untuk meringankan biaya sekaligus bisa sebagai pendapatan tambahan untuk rumah sakit.Tujuan: Studi ini bertujuan untuk mengetahui faktor-faktor penyebab kurang optimalnya pengelolaan limbah medis B3 di Rumah Sakit Umum (RSU) Surya Husadha melalui pemberdayaan bank sampah.Metode: Penelitian ini menggunakan pendekatan kualitatif dengan purposive sampling di RSU Surya Husadha. Teknik pengumpulan data yang dilakukan adalah melalui observasi, wawancara mendalam serta dokumentasi dari enam informan.Hasil: Ditemukan adanya beberapa kendala yang menyebabkan penerapan bank sampah di RSU Surya Husadha dalam mengurangi beban biaya pengelolaan limbah medis B3 menjadi kurang optimal. Kendala tersebut berupa keterbatasan sumber daya manusia serta keterbatasan ketersediaan sarana prasarana. Adanya kendala tersebut menyebabkan dari empat jenis limbah medis B3 yang bisa dikelola melalui bank sampah sesuai Peraturan Menteri Lingkungan Hidup dan Kehutanan (LHK) RI No 56 Tahun 2015 hanya dua yang bisa dikelola yaitu botol infus bekas dan bekas kemasan cairan hemodialisis.Kesimpulan: Pelaksanaan pengelolaan limbah medis B3 di RSU Surya Husadha sudah sesuai regulasi, namun evaluasi terhadap kendala-kendala, perencanaan kebutuhan tenaga, dan juga pengadaan sarana prasarana yang dibutuhkan dalam menunjang kegiatan bank Sampah sangat diperlukan untuk membantu mengurangi biaya pengelolaan limbah medis B3.
The effect of Modified Radical Mastectomy (MRM) with and without latissimus dorsi flap on seroma of Locally Advanced Breast Cancer (LABC) in Sanglah Hospital
Authors: Pramana Anak Agung Chris Tedy , Widiana I Ketut , Widiana I Gde Raka
Published: February 2022

Background: Locally Advanced Breast Cancer (LABC) is defined as breast cancer spread locoregionally and without any signs of metastasis. Stage IIIA breast cancer is one type of LABC that can be removed surgically, and Modified Radical Mastectomy (MRM) remains the first surgical option. Seroma production is one of the most common complications post MRM, with the hypothesis stating that the Latissimus Dorsi (LD) flap technique is responsible for resulting in higher seroma output. This study aims to compare seroma production in LABC patients post MRM with and without LD flap.Methods: This prospective cohort study was conducted in Sanglah General Hospital, Denpasar, between November 2018 and January 2020. The study sample was divided into 2 groups: LABC patients post MRM with and without LD flap reconstruction. Seroma was measured in milliliters (ml) and collected from the first to fifth day post-operation. Data were analyzed using SPSS version 21 for Windows.Results: Forty LABC patients were enrolled in this study. The mean age for the group without latissimus dorsi flap was 48.45±7.01 years and 49.40±10.77 years for the group with latissimus dorsi flap. The mean seroma production in LABC patients who underwent MRM without and with LD flap reconstruction was 696.45±66.37 ml and 490.10±62.11 ml. There was a significant difference in the total of seroma between the treatment group without-LD flap and compared to with-LD flap reconstruction (p<0.001).Conclusion: Seroma production is significantly higher in LABC patients post MRM without LD flap reconstruction than LABC patients with LD flap.
Perbandingan kadar Thyroid Stimulating Hormone (TSH) dan kadar Free T4 (FT4) antara metode Fluorescence Immunoassay (FIA) dan metode Electrochemiluminescence Immunoassay (ECLIA) di RSUP Sanglah, Bali, Indonesia
Authors: Nabu Ekarini Katharina Yunarti , Herawati Sianny , Mulyantari Ni Kadek , Lestari Anak Agung Wiradewi , Prabawa I Putu Yuda
Published: February 2022

Background: Diagnostic and therapeutic cases of hyperthyroidism can be identified by examining the levels of Thyroid Stimulating Hormone (TSH) and Free T4 (FT4). There are several examination methods, namely the Fluorescence Immunoassay (FIA) and the Electro-Chemiluminescence Immunoassay (ECLIA) method. This study aims to evaluate the difference in TSH and FT4 level in the FIA method and ECLIA method.Method: This study used observational analytic methods cross sectional design, with 45 samples serum patient with hyperthyroid in January-March 2019. Examine level TSH and FT4 levels with FIA methods (NANO ENTEK FRENDTM) and ECLIA method (Cobas e601 ROCHE). Data were analyzed using SPSS version 17 for Windows.Results: Most of the respondents were aged 25-34 years (28.8%) and female (86.7%). There was no significant difference in the mean TSH level on examination using the ECLIA method (0.60±0.79 mIU/L) and the FIA method (0.63±0.76 mIU/L) (p=0.639). In addition, there was no significant difference in FT4 both in the examination using the ECLIA method (1.67±1.05 ng/dl) and the FIA method (1.69±1.72 ng/dl) (p=0.745).Conclusions: There was no significant difference between TSH and FT4 in both ECLIA and FIA methods. Latar Belakang: Diagnosis maupun pemantauan terapi kasus hipertiroid dapat diketahui dengan pemeriksaan kadar hormon Thyroid Stimulating Hormone (TSH) dan Free T4 (FT4). Terdapat beberapa metode pemeriksaan yaitu metode Fluorescence Immunoassay (FIA) dan metode Electro-Chemiluminescence Immunoassay (ECLIA). Penelitian ini bertujuan untuk mengevaluasi perbedaan kadar TSH dan FT4 metode FIA dan metode ECLIA.Metode: Penelitian ini menggunakan metode observasional analitik dengan desain potong lintang pada 45 sampel serum penderita hipertiroid selama periode Januari-Maret 2019. Dilakukan pemeriksaan kadar TSH dan FT4 dengan metode FIA (NANO ENTEK FRENDTM) dan metode ECLIA (Cobas e601 Roche). Data dianalisis dengan SPSS versi 17 untuk Windows.Hasil: Sebagian besar responden berusia 25-34 tahun (28,8%) dan berjenis kelamin perempuan (86,7%). Tidak terdapat perbedaan bermakna rerata kadar TSH pada pemeriksaan menggunakan metode ECLIA (0,60±0,79 mIU/L) maupun metode FIA (0,63±0,76 mIU/L) (p=0,639). Disamping itu, tidak juga terdapat perbedaan bermakna rerata kadar FT4 baik pada pemeriksaan menggunakan metode ECLIA (1,67±1,05 ng/dl) maupun metode FIA (1,69±1,72 ng/dl) (p=0,745).Kesimpulan: Tidak ada perbedaan yang bermakna antara kadar TSH dan FT4 pada metode ECLIA dan FIA.
Inflammation after corneoscleral rupture and traumatic cataract due to blunt trauma in a child: a case report
Authors: Suhardi Clara Verlina , Bungaran Graecia , Ihsan Nashrul
Published: February 2022

Background: Ocular trauma is the most common cause of acquired monocular blindness in children. It is because of the inflammation following corneoscleral rupture and traumatic cataracts due to blunt trauma. This case study aims to evaluate the corneoscleral rupture and traumatic cataracts due to blunt trauma in a child.Case Presentation: We present a 5-year-old male who sustained blunt trauma to his right eye. He presented with blurry vision, mild pain and watering from the affected eye. His examination revealed visual acuity of 6/60 in the right eye (RE), corneal laceration extending from 3 o’clock towards 11 o’clock with possible extension to the sclera, and cortical lens matter in the anterior chamber. The patient underwent globe rupture repair under general anesthesia immediately. Postoperative day one revealed 2 mm hypopyon thick inflammation cells and fibrin. He was on topical steroids and topical antibiotics. The fourth postoperative day showed reduced inflammation, wound sutures in place and absence of hypopyon, thick membranous in the pupil. The patient is then referred to the Pediatric Ophthalmology department for a follow-up operation of clearing lens particle remnants to reduce inflammation and IOL insertion. Conclusion:  Management of the injury and traumatic cataract is crucial to prevent vision loss and amblyopia, to maintain binocularity, prevent strabismus or even phthisis bulbi. Along with early management, routine follow-up examination for prevention of other unwanted complications is advised.
Peran sirkumsisi sebagai pencegahan infeksi herpes genetalis: suatu studi kohort retrospektif
Authors: Wardhana Made , Windari Martina , Sadeli Marrietta Sugiarti , Wiraguna Anak Agung Gde Putra , Puspawati Ni Made Dwi , Indira I Gusti Ayu Agung Elis , Mahariski Pande Agung
Published: February 2022

Background: Recurrent genital herpes (RGH) is a sexually transmitted infection that is a serious public health problem and is quite prominent in most countries worldwide. Management for this infection is antiviral and circumcision. Male circumcision significantly reduces human immunodeficiency virus (HIV) infection and other sexually transmitted infections. This research aims to evaluate circumcision efficacy as the prevention for herpes simplex virus type 2 (HSV-2) infection compared with oral acyclovir.Methods: This research is an experimental study with a retrospective cohort approach. We included 45 males, 24 subjects circumcised and 21 subjects without circumcision and took oral acyclovir as standard treatment. RGH was diagnosed based on typical clinical manifestation. Follow up treatment every two weeks and continued to 2 months after circumcised and given with oral acyclovir. Successful treatment was stated without recurrent genital herpes.Results: Of 24 circumcised subjects, 19 were cured, and five non-circumcised subjects suffered recurrent genital herpes (not cured). Among 21 subjects without circumcision was cured, and 12 subjects were not cured. Based on these results, the value of NNT= 2.7.Conclusion: Circumcision can be considered effective in reducing the incidence of HGR and prevent recurrence of HGR with the NNT value of 2.7.  Latar Belakang: Herpes genetalis rekuren (HGR) merupakan infeksi menular seksual menjadi masalah kesehatan masyarakat yang serius dan cukup menonjol pada sebagian besar negara di dunia. Penanganannya adalah oral dengan antivirus dan tindakan sirkumsisi. Sirkumsisi pada pria secara signifikan mengurangi insiden infeksi human immunodeficiency virus (HIV) dan penyakit infeksi menular lainnya. Penelitian ini mengevaluasi efikasi sirkumsisi sebagai pencegahan infeksi virus herpes simpleks tipe 2 (HSV-2) dibandingkan dengan pemberian obat asiklovir.Metode: Studi ekperimental dengan pendekatan retrospektif kohort dengan mengikutsertakan 45 subjek pria dewasa, 24 subjek disirkumsisi dan 21 tanpa sirkumsisi dan hanya diberikan asiklovir sebagai obat standar. Diagnosis HGR dilakukan secara klinis dengan yang manifestasi klinis yang khas da pemeriksaan Tzanck. Setelah pemberian terapi dilakukan kontrol setiap 2 minggu sampai 2 bulan. Terapi dinyatakan berhasil bila tidak ada kekambuhan.Hasil: Dari 24 subjek disirkumsisi, 19 subjek dinyatakan sembuh dan 5 subjek mengalami kekambuhan (tidak sembuh). Dari 21 subjek tanpa sirkumsisi, 9 subjek dinyatakan sembuh dan 12 subjek dinyatakan tidak sembuh. Berdasarkan hasil ini didapatkan nilai NNT=2,7.Simpulan: Sirkumsisi dapat dinilai cukup efektif mengurangi angka kejadian HGR dan dapat mencegah kekambuhan HGR dengan nilai NNT 2.7.
Problem diagnostik seorang penderita endokarditis infektif dengan komplikasi perdarahan intrakranial: Sebuah laporan kasus
Authors: Simarmata Franky , Nugraha Ida Bagus Aditya , Wita I Wayan , Sindhughosa Dwijo Anargha
Published: February 2022

Introduction: Infective Endocarditis (IE) is a disease frequently affecting heart valves. The diagnosis is relatively simple, however it could be difficult in unspecific symptoms. Intracranial complications of patients with IE rarely happen.Case: The case was a 64 years-old male with sudden decrease of consciousness 12 hours prior to admission and diagnosed as a hemorrhagic stroke. He had a history of heavy smoking for about 10 years. Infective Endocarditis (IE) was diagnosed by Duke Criteria, and from this patient we found the vegetation at mitral valve with diameter 1.09 x 0.73 cm. Treatment for the patient is antibiotic according to sensitivity test of blood culture. The patient was discharged with improvement of condition. However, in approximately three months after discharge, the patient got hospitalized again due to the same condition and passed away.Conclusion: Infective endocarditis is a relatively rare disease. In our case we had a definite IE patient with a spectrum of neurological events complicating this disease. The presence of cerebral hemorrhage complications makes the patient's prognosis worse.  Pendahuluan: Endokarditis Infektif (IE) merupakan penyakit yang umumnya menyerang katup jantung. Diagnosis pada umumnya relatif sederhana, namun dapat menjadi sulit gejala yang ditemukan tidak spesifik. Komplikasi intrakranial pasien dengan IE jarang terjadi.Laporan Kasus: Seorang laki-laki 64 tahun dengan penurunan kesadaran mendadak 12 jam sebelum masuk rumah sakit (MRS) dan didiagnosis sebagai stroke hemoragik. Pasien memiliki riwayat perokok berat selama kurang lebih 10 tahun. Endokarditis infektif (IE) di diagnosis dengan kriteria Duke, dan dari pasien ini ditemukan vegetasi pada katup mitral dengan diameter 1,09 x 0,73 cm. Pengobatan untuk pasien adalah antibiotik berdasarkan uji sensitivitas kultur darah. Pasien dipulangkan dengan kondisi perbaikan. Namun, sekitar tiga bulan setelah keluar, pasien kembali dirawat di rumah sakit karena kondisi yang sama dan meninggal dunia.Simpulan: Endokarditis infektif merupakan penyakit yang relatif jarang. Dalam laporan kasus ini, pasien dengan spektrum kejadian neurologis yang menyulitkan penyakit IE. Adanya komplikasi perdarahan otak membuat prognosis pasien semakin buruk.
Mikrobiota usus pada dermatitis atopik
Authors: Gotama Dewi , Wardhana Made , Santoso Adeline , Sissy Sissy
Published: February 2022

Atopic dermatitis (AD) is a multifactorial disease caused by immune dysregulation, genetic susceptibility, environmental factors, and impaired barrier function. The health burden caused by this disease is significant and can impact psychological, social and financial costs, along with systemic comorbidities. Several studies have reported the gut microbiota in AD patients. Several studies have reported the gut microbiota in AD patients. The gut microbiota is thought to play an important role in the development of AD by regulating the immune system's maturation. Intestinal microbiota alteration affects the balance of the immune system through metabolites' production, which will cause the microenvironment to become inflamed. Currently, the close relationship between the gut microbiota and the development of the immune system, especially in maintaining the balance of Th-1 and Th-2 responses, is the rationale for providing probiotic supplements to prevent or treat allergic and atopic diseases.  Dermatitis atopik (DA) merupakan penyakit multifaktorial yang diakibatkan disregulasi imun, suseptibilitas genetik, faktor lingkungan, dan gangguan fungsi barier. Beban kesehatan yang diakibatkan penyakit ini bersifat signifikan dan dapat berdampak pada kerugian psikologis, sosial, dan finansial, disertai komorbiditas sistemik. Terdapat beberapa studi yang telah melaporkan mikrobiota usus pada pasien DA. Mikrobiota usus diduga memainkan peran penting dalam perkembangan DA dengan meregulasi maturasi sistem imun. Alterasi mikrobiota usus mempengaruhi keseimbangan sistem imun melalui produksi metabolit, yang akan menyebabkan lingkungan mikro mengalami inflamasi. Saat ini hubungan erat antara mikrobiota usus dan perkembangan sistem imun, khususnya dalam menjaga keseimbangan respon Th-1 dan Th-2 menjadi dasar pemikiran pemberian suplemen probiotik untuk mencegah atau mengatasi penyakit alergi dan atopi.