bluuebunny/crossref_metadata_2025 huggingface dataset:
Concise Synthesis and Two‐Photon‐Excited Deep‐Blue Emission of 1,8‐Diazapyrenes
Authors: He Tingchao , Too Pei Chui , Chen Rui , Chiba Shunsuke , Sun Handong
Published: June 2012

Efficient violet–blue‐emitting molecules are especially useful for applications in full‐color displays, solid‐state lighting, as well as in two‐photon absorption (TPA) excited frequency‐upconverted violet–blue lasing. However, the reported violet–blue‐emitting molecules generally possess small TPA cross sections. In this work, new 1,8‐diazapyrenes derivatives 3 with blue two‐photon‐excited fluorescence emission were concisely synthesized by the coupling reaction of readily available 1,4‐naphthoquinone O,O‐diacetyl dioxime (1) with internal alkynes 2 under the [{RhCl2Cp*}2]–Cu(OAc)2 (Cp*=pentamethylcyclopentadienyl ligand) bimetallic catalytic system. Elongation of the π‐conjugated length of 1,8‐diazapyrenes 3 led to the increase of TPA cross sections without the expense of a redshift of the emission wavelength, probably due to the rigid planar structure of chromophores. It is especially noteworthy that 2,3,6,7‐tetra(4‐bromophenyl)‐1,8‐diazapyrene (3c) has a larger TPA cross section than those of other molecules reported so far. These experimental results are explained in terms of the effects of extension of the π‐conjugated system, intramolecular charge transfer, and reduced detuning energy.
Chiral‐Substrate‐Assisted Stereoselective Epoxidation Catalyzed by H2O2‐Dependent Cytochrome P450SPα
Authors: Fujishiro Takashi , Shoji Osami , Kawakami Norifumi , Watanabe Takahiro , Sugimoto Hiroshi , Shiro Yoshitsugu , Watanabe Yoshihito
Published: June 2012

The stereoselective epoxidation of styrene was catalyzed by H2O2‐dependent cytochrome P450SPα in the presence of carboxylic acids as decoy molecules. The stereoselectivity of styrene oxide could be altered by the nature of the decoy molecules. In particular, the chirality at the α‐positions of the decoy molecules induced a clear difference in the chirality of the product: (R)‐ibuprofen enhanced the formation of (S)‐styrene oxide, whereas (S)‐ibuprofen preferentially afforded (R)‐styrene oxide. The crystal structure of an (R)‐ibuprofen‐bound cytochrome P450SPα (resolution 1.9 Å) revealed that the carboxylate group of (R)‐ibuprofen served as an acid–base catalyst to initiate the epoxidation. A docking simulation of the binding of styrene in the active site of the (R)‐ibuprofen‐bound form suggested that the orientation of the vinyl group of styrene in the active site agreed with the formation of (S)‐styrene oxide.
Polymer‐Supported Bimetallic Ag@AgAu Nanocomposites: Synthesis and Catalytic Properties
Authors: Zhang Shaofeng , Wu Wei , Xiao Xiangheng , Zhou Juan , Xu Jinxia , Ren Feng , Jiang Changzhong
Published: June 2012

Supported noble bimetallic nanomaterials have attracted great interest owing to their applications in catalysis. Herein, polystyrene‐supported Ag@AgAu bimetallic nanocomposites were synthesized by using a seed‐growth route. The size and degree of coverage of the Ag@AgAu NPs could be controlled by changing the experimental parameters. SEM, TEM, STEM, EDS, and XPS analysis was used to characterize the morphology, structure, and composition of these nanocomposites. We found that the bimetallic nanoparticles on the polystyrene beads had a core–shell structure that was comprised of a Ag core and a AgAu alloy shell. The optical properties of the nanocomposites were also studied by UV/Vis/NIR spectroscopy, which indicated that the localized surface plasmon resonance (LSPR) absorptions of the nanocomposites could be tailored over a large scale from 450 nm to 950 nm. The catalytic properties of the nanocomposites were studied by using the reduction of 4‐nitrophenol (4‐NP) by NaBH4 as a model system. The results showed that the catalytic activity of the polystyrene‐supported Ag@AgAu bimetallic nanocomposites was remarkably superior to that of polystyrene‐supported monometallic Ag and Au nanocomposites with the same nanoparticle size. In addition, an investigation of the recycling catalytic activity of the PS‐Ag@AgAu nanocomposites revealed that the catalyst possessed good stability. The enhancement of the catalytic activity was proposed to be due to the ligand and strain effects between Ag and Au.
Synthesis and Tunable Reactivity of N‐Heterocyclic Germylene
Authors: Xiong Yun , Yao Shenglai , Driess Matthias
Published: June 2012

Modifying the β‐diketimine ligand LH 1 (LH=[ArNC(Me)CHC(Me)NHAr], Ar=2,6‐iPr2C6H3) through replacement of the proton in 3‐position by a benzyl group (Bz) leads to the new BzLH ligand 2, which could be isolated in 77 % yield. According to 1H NMR spectroscopy, 2 is a mixture of the bis(imino) form [(ArNC(Me)]2CH(Bz) 2a and its tautomer [ArNC(Me)C(Bz)C(Me)NHAr] 2b. Nevertheless, lithiation of the mixture of 2a and 2b affords solely the N‐lithiated β‐diketiminate [ArNC(Me)C(Bz)C(Me)NLiAr], BzLLi 3. The latter reacts readily with GeCl2⋅dioxane to form the chlorogermylene BzLGeCl 4, which serves as a precursor for a new zwitterionic germylene by dehydrochlorination with LiN(SiMe3)2. This reaction leads to the zwitterionic germylene BzL′Ge: 5 (BzL′=ArNC(CH2)C(Bz)C(Me)NAr) which could be isolated in 83 % yield. The benzyl group has a distinct influence on the reactivity of zwitterionic 5 in comparison to its benzyl‐free analogue, as shown by the reaction of 5 with phenylacetylene, which yields solely the 1,4‐addition product 6, that is, the alkynyl germylene BzLGeCCPh. Compounds 2–8 have been fully characterized by multinuclear NMR spectroscopy, mass spectrometry, elemental analyses, and single‐crystal X‐ray diffraction analyses.
Highway drivers' willingness to pay for speeding violations in Taiwan
Authors: Jou Rong‐Chang , Chen Ke‐Hong
Published: June 2012

This study investigates the effects of various factors on highway drivers' speeding behaviour and estimates the amount of money that a highway driver is willing to pay for speeding violations in Taiwan. The contingent valuation method is applied to measure drivers' preference and to derive the value function of the amount of money. Logit and probit models are estimated to analyse the significant variables influencing speeding behaviour and to calculate the willingness to pay for speeding violations. The research results show that increasing speeding fines is an effective way to reduce illegal driving behaviour on highways. Significant variables affecting highway drivers' speeding behaviour include gender, engine capacity, past offenders in the previous year, and the risk‐seeking characteristics of drivers. Finally, the logit and probit models show that the amounts of money that highway drivers are willing to pay for speeding violations are $US119 and $US116, respectively. Copyright © 2012 John Wiley & Sons, Ltd.
Promotion of epithelial–mesenchymal transition and tumor growth by 17β‐estradiol in an ER+/HER2+ cell line derived from human breast epithelial stem cells
Authors: Wang Kai‐Hung , Kao An‐Pei , Lin Ta‐Chin , Chang Chia‐Cheng , Kuo Tsung‐Cheng
Published: June 2012

A tumorigenic cell line with estrogen receptor and HER2 expression (ER/HER2+), R2N1d, was developed from a human breast epithelial cell type with stem cell characteristics in a growth factor/hormone‐deprived cell culture condition. This study was undertaken to test whether tumor growth and other biological effects could be induced by estrogen in this cell line. The results clearly show that estrogen treatment greatly promoted the tumor growth of R2N1d cells in immune‐deficient mice. Estrogen treatment of R2N1d cells in vitro was also found to induce other phenotypic changes related to breast carcinogenesis, that is, 1) the induction of epithelial–mesenchymal transition (EMT) shown by molecular and functional marker changes; 2) a significant increase of the CD44high/CD24−/low stem cell population; 3) the enhancement of cell growth rate and colony‐forming ability; and 4) the acquisition of metastatic ability, that is, increased cell migration and invasiveness. From these results, we conclude that 1) estrogen could induce EMT and cancer stem cells and promote tumor growth in ER+/HER2+ cells known to be derived from human breast epithelial stem cells, and 2) normal stem cells could give rise to cancer stem cells.
Application of bioluminescence ATP measurement for evaluation of fungal viability of foxing spots on old documents
Authors: Rakotonirainy Malalanirina Sylvia , Dubar Pauline
Published: June 2012

An adenosine triphosphate (ATP) bioluminescence‐based protocol was tested to assess the viability of fungal species in old documents damaged by foxing. Foxing appears as scattered yellow brownish‐red stains, damaging the aesthetics of documents and their long‐term readability. In the field of cultural heritage conservation, the debate over the mechanism of foxing is ongoing. Previous studies found evidence of mold‐like structures in some coloured areas; however, many species have not yet been identified and their role in the phenomenon is not understood. To better understand their involvement in this type of paper decay, we focused our attention first on their viability. We demonstrated the reliability and sensitivity of the ATP bioluminescence assay compared with conventional methods based on cultivation, which has rarely given rise to in vitro growth from foxed papers. From nine books dating back from the 19th and 20th centuries, the mean ATP amount of foxed spots ranged from 0.29 to 3.63 ng/cm2, suggesting the presence of strains inside the brownish spots and providing evidence of their viability. Outside the spots, ATP content was considered negligible, with a mean ATP amount of 0 to 0.03 ng/cm2. ATP assay appears to be a useful and robust method for the detection and quantification of viable elements in foxing spots. Copyright © 2012 John Wiley & Sons, Ltd.
Microwave‐assisted aqueous synthesis of new quaternary‐alloyed CdSeTeS quantum dots; and their bioapplications in targeted imaging of cancer cells
Authors: Yang Fengzhao , Xu Zhancheng , Wang Jinjie , Zan Feng , Dong Chaoqing , Ren Jicun
Published: June 2012

In this study, we report for the first time a one‐pot approach for the synthesis of new CdSeTeS quaternary‐alloyed quantum dots (QDs) in aqueous phase by microwave irradiation. CdCl2 was used as a Cd precursor during synthesis, NaHTe and NaHSe were used as Te and Se precursors and mercaptopropionic acid (MPA) was used as a stabilizer and source of sulfur. A series of quaternary‐alloyed QDs of different sizes were prepared. CdSeTeS QDs exhibited a wide emission range from 549 to 709 nm and high quantum yield (QY) up to 57.7 %. Most importantly, the quaternary‐alloyed QDs possessed significantly long fluorescence lifetimes > 100 ns as well as excellent photostability. Results of high‐resolution transmission electron microscopy (HRTEM), energy dispersive X‐ray spectroscopy (EDX) and powder X‐ray diffraction (XRD) spectroscopy showed that the nanocrystals possessed a quaternary alloy structure with good crystallinity. Fluorescence correlation spectroscopy (FCS) showed that QDs possessed good water solubility and monodispersity in aqueous solution. Furthermore, CdSeTeS QDs were modified with alpha‐thio‐omega‐carboxy poly(ethylene glycol) (HS‐PEG‐COOH) and the modified QDs were linked to anti‐epidermal growth factor receptor (EGFR) antibodies. QDs with the EGFR antibodies as labeling probes were successfully applied to targeted imaging for EGFR on the surface of SiHa cervical cancer cells. We believe that CdSeTeS QDs can become useful probes for in vivo targeted imaging and clinical diagnosis. Copyright © 2012 John Wiley & Sons, Ltd.
Engineering of self‐sustaining systems: Substituting the yeast glucose transporter plus hexokinase for the Lactococcus lactis phosphotransferase system in a Lactococcus lactis network in silico
Authors: Adamczyk Malgorzata , Westerhoff Hans V.
Published: June 2012

The success rate of introducing new functions into a living species is still rather unsatisfactory. Much of this is due to the very essence of the living state, i.e. its robustness towards perturbations. Living cells are bound to notice that metabolic engineering is being effected, through changes in metabolite concentrations. In this study, we asked whether one could engage in such engineering without changing metabolite concentrations. We have illustrated that, in silico, one can do so in principle. We have done this for the case of substituting the yeast glucose transporter plus hexokinase for the Lactococcus lactis phosphotransferase system, in an L. lactis network, this engineering is 'silent' in terms of metabolite concentrations and almost all fluxes.
Wasserlinsen als Nutzpflanzen
Authors: Appenroth Klaus‐J. , Lam Eric
Published: June 2012

Vertreter aus der Familie der Wasserlinsengewächse sind nicht nur interessant, weil sie die kleinsten Blütenpflanzen repräsentieren, sie besitzen vielmehr auch die höchste Produktivität bei der Erzeugung von Biomasse. Ihre Produktion steht nicht in Konkurrenz zu anderen landwirtschaftlichen Nutzpflanzen, da sie auf Aquakultur angewiesen sind. Zudem trägt ihre Kultivierung nicht zur weiteren Eutrophierung der Gewässer bei. Vielmehr können sie auf kommunalen und landwirtschaftlichen Abwässern kultiviert werden und nehmen im Verlauf von Vermehrung und Wachstum die Nährstoffe auf. Sie können daher zur Gewässerreinigung eingesetzt werden. Die erzeugte Biomasse ist kein Abfall, sondern wertvolles Ausgangsmaterial für Tierernährung und zur Erzeugung von Bioalkohol. Die Untersuchungen haben inzwischen bereits das Forschungslabor teilweise verlassen und werden in technischen Pilotanlagen fortgesetzt, so in New Jersey und North Carolina (USA), Chengdu (China), und Armidale (Australien).
Europäische Trockenrasen schlagen tropische Regenwälder
Authors: Dengler Jürgen
Published: June 2012

Tropische Regenwälder gelten als die artenreichsten Lebensräume der Erde. Nun zeigt eine neue Studie, dass bei Betrachtung kleiner Flächen europäische Halbtrockenrasen die Gefäßpflanzendiversität der Tropenwälder übertreffen. Paradoxerweise könnte gerade die (extensive) menschliche Nutzung einer der Gründe für den hohen Artenreichtum von Grasländern der gemäßigten Zone sein. Heute ist dieser Vegetationstyp durch Nutzungsaufgabe und ‐intensivierung ähnlich stark gefährdet wie tropische Regenwälder.
Cardiopulmonary exercise testing for preoperative risk assessment before hepatic resection
Authors: Junejo M A , Mason J M , Sheen A J , Moore J , Foster P , Atkinson D , Parker M J , Siriwardena A K
Published: June 2012

Background

Contemporary liver surgery practice must accurately assess operative risk in increasingly elderly populations with greater co-morbidity. This study evaluated preoperative cardiopulmonary exercise testing (CPET) in high-risk patients undergoing hepatic resection.

Methods

In a prospective cohort referred for liver resection, patients aged over 65 years (or younger with co-morbidity) were evaluated by preoperative CPET. Data were collected prospectively on functional status, postoperative complications and survival.

Results

Two hundred and four patients were assessed for hepatic resection, of whom 108 had preoperative CPET. An anaerobic threshold (AT) of 9·9 ml O2 per kg per min predicted in-hospital death and subsequent survival. Below this value, AT was 100 per cent sensitive and 76 per cent specific for in-hospital mortality, with a positive predictive value (PPV) of 19 per cent and a negative predictive value (NPV) of 100 per cent: no deaths occurred above the threshold. Age and respiratory efficiency in the elimination of carbon dioxide (V̇E/V̇CO2) at AT were statistically significant predictors of postoperative complications. Receiver operating characteristic (ROC) curve analysis showed that a threshold of 34·5 for V̇E/V̇CO2 at AT provided a specificity of 84 per cent and a sensitivity of 47 per cent, with a PPV of 76 (95 per cent confidence interval (c.i.) 58 to 88) per cent and a NPV of 60 (48 to 72) per cent for postoperative complications. Long-term survival of those with an AT of less than 9·9 ml O2 per kg per min was significantly worse than that of patients with a higher AT (hazard ratio for mortality 1·81, 95 per cent c.i. 1·04 to 3·17; P = 0·036).

Conclusion

CPET provides a useful prognostic adjunct in the preoperative assessment of patients undergoing hepatic resection.
Cholecystectomy-related bile duct and vasculobiliary injuries
Authors: Sarno G , Al-Sarira A A , Ghaneh P , Fenwick S W , Malik H Z , Poston G J
Published: June 2012

Background

Combined vasculobiliary injury is a serious complication of cholecystectomy. This study examined medium- to long-term outcomes after such injury.

Methods

Patients referred to this institution with Strasberg type E bile duct injuries were identified from a prospectively maintained database (1990–2010). Long-term outcomes were evaluated by chart review.

Results

Sixty-three patients were referred with bile duct injury alone (45 patients) or vasculobiliary injury (18). Thirty patients (48 per cent) had septic complications before transfer. Twenty-six patients (41 per cent) had long-term biliary complications over a median follow-up of 96 (range 12–245) months. Nine patients (3 with bile duct injury, 6 with vasculobiliary injury) required further interventions after a median of 22 (8–38) months; five required biliary surgical revision and four percutaneous dilatation of biliary strictures. Vasculobiliary injury and injury-related sepsis were independent risk factors for treatment failure: hazard ratio 7·79 (95 per cent confidence interval 2·80 to 21·70; P < 0·001) and 4·82 (1·69 to 13·68; P = 0·003) respectively.

Conclusion

Outcome following bile duct injury repair was worse in patients with concomitant vasculobiliary injury and/or sepsis.
Early hepatic regeneration index and completeness of regeneration at 6 months after partial hepatectomy
Authors: Kele P G , de Boer M , van der Jagt E J , Lisman T , Porte R J
Published: June 2012

Background

The liver is known to regenerate following partial hepatectomy (PH), but little is known about the timing and completeness of regeneration relative to the resected volume. This study examined whether liver volume regeneration following PH and its completeness 6 months after surgery is related to the resected volume.

Methods

A consecutive series of patients undergoing PH were included. All patients underwent preoperative computed tomography (CT) before and 7 days after surgery. Additional scans were performed 6 months after operation. Preoperative total liver volume (TLV), resected volume, future liver remnant (FLR) and liver remnant (LR) volumes were measured on CT images by freehand drawing of regions of interest in the portal venous phase on 2-mm thick slices. Regeneration indices were calculated at 7 days (RIearly) and 6 months (RItotal) using the formula 100 × (LR volume—FLR volume)/FLR volume. Patients were classified into five groups based on resected volume as a percentage of TLV: 0–19, 20–39, 40–59, 60–69 and at least 70 per cent in groups 1–5 respectively.

Results

Ninety-one patients were enrolled. RIearly varied from 11 to 66 per cent in groups 1–5 (P < 0·001). RIearly did not increase linearly with increasing resection volume and a plateau was seen from group 3 and above. In contrast, RItotal was related linearly to resected volume; values ranged from 21 to 233 per cent in groups 1–5 (P < 0·001). At 7 days, LR volume represented 97, 87, 70, 58 and 41 per cent of TLV in groups 1–5. At 6 months, respective values were 102, 99, 87, 82 and 91 per cent.

Conclusion

Early postoperative liver volume regeneration was not related linearly to resected volume. At 6 months after surgery, RI was related linearly to resected volume, but LRs had not yet regenerated to preoperative TLV.
Arterial vascularization patterns of the splenium: An anatomical study
Authors: Kahilogullari G. , Comert A. , Ozdemir M. , Brohi R.A. , Ozgural O. , Esmer A.F. , Egemen N. , Karahan S.T.
Published: June 2012

The aim of this study was to provide detailed information about the arterial vascularization of the splenium of the corpus callosum (CC). The splenium is unique in that it is part of the largest commissural tract in the brain and a region in which pathologies are seen frequently. An exact description of the arterial vascularization of this part of the CC remains under debate. Thirty adult human brains (60 hemispheres) were obtained from routine autopsies. Cerebral arteries were separately cannulated and injected with colored latex. Then, the brains were fixed in formaldehyde, and dissections were performed using a surgical microscope. The diameter of the arterial branches supplying the splenium of the CC at their origin was investigated, and the vascularization patterns of these branches were observed. Vascular supply to the splenium was provided by the anterior pericallosal artery (40%) from the anterior circulation and by the posterior pericallosal artery (88%) and posterior accessory pericallosal artery (50%) from the posterior circulation. The vascularization pattern of the splenium differs in each hemisphere and is usually supplied by multiple branches. The arterial vascularization of the splenium of the CC was studied comprehensively considering the ongoing debate and the inadequacy of the studies on this issue currently available in the literature. This anatomical knowledge is essential during the treatment of pathologies in this region and especially for splenial arteriovenous malformations. Clin. Anat. 26:675–681, 2013. © 2012 Wiley Periodicals, Inc.
Anatomical and mechanical relationship between the proximal attachment of adductor longus and the distal rectus sheath
Authors: Norton‐old Kimberley J. , Schache Anthony G. , Barker Priscilla J. , Clark Ross A. , Harrison Simon M. , Briggs Christopher A.
Published: June 2012

The objectives of this study were to investigate the anatomical relationship between the proximal adductor longus (AL) and rectus abdominis muscles and to determine whether unilateral loading of AL results in strain transmission across the anterior pubic symphysis to the contralateral distal rectus sheath. Bilateral dissections were conducted on 10 embalmed cadavers. Strain transfer across the pubic symphysis was examined on seven of these cadavers. An AL contraction was simulated by applying a controlled load in the direction of its proximal tendinous fibers, and the resultant strain in the contralateral distal rectus sheath was measured using a foil‐type surface mounted microstrain gage. Adductor longus attached to the antero‐inferior aspect of the pubis. In 18 of the 20 limbs, the proximal attachment of AL was tendinous on its superficial surface and muscular on its deep surface. The proximal AL tendon was found in most instances to have secondary communications with structures such as the contralateral distal rectus sheath, pubic symphysis anterior capsule, ilio‐inguinal ligament, and contralateral proximal AL tendon. Despite these consistent anatomical observations, strain measured in the contralateral distal rectus sheath upon unilateral loading of the proximal AL varied considerably between cadavers. Measured strain had an average ± 1SD of 0.23 ± 0.43%. The proximal attachment of AL contributes to an anatomical pathway across the anterior pubic symphysis that is likely required to withstand the transmission of large forces during multidirectional athletic activities. This anatomical relationship may be a relevant factor in explaining the apparent vulnerability of the AL and rectus abdominis attachments to injury. Clin. Anat. 2013. © 2012 Wiley Periodicals, Inc.
IGF and myostatin pathways are respectively induced during the earlier and the later stages of skeletal muscle hypertrophy induced by clenbuterol, a β2‐adrenergic agonist
Authors: Abo Tokuhisa , Iida Ryo‐hei , Kaneko Syuhei , Suga Takeo , Yamada Hiroyuki , Hamada Yoshiki , Yamane Akira
Published: June 2012

Clenbuterol, a β2‐adrenergic agonist, increases the hypertrophy of skeletal muscle. Insulin‐like growth factor (IGF) is reported to work as a potent positive regulator in the clenbuterol‐induced hypertrophy of skeletal muscles. However, the precise regulatory mechanism for the hypertrophy of skeletal muscle induced by clenbuterol is unknown. Myostatin, a member of the TGFβ super family, is a negative regulator of muscle growth. The aim of the present study is to elucidate the function of myostatin and IGF in the hypertrophy of rat masseter muscle induced by clenbuterol. To investigate the function of myostatin and IGF in regulatory mechanism for the clenbuterol‐induced hypertrophy of skeletal muscles, we analysed the expression of myostatin and phosphorylation levels of myostatin and IGF signaling components in the masseter muscle of rat to which clenbuterol was orally administered for 21 days. Hypertrophy of the rat masseter muscle was induced between 3 and 14 days of oral administration of clenbuterol and was terminated at 21 days. The expression of myostatin and the phosphorylation of smad2/3 were elevated at 21 days. The phosphorylation of IGF receptor 1 (IGFR1) and akt1 was elevated at 3 and 7 days. These results suggest that myostatin functions as a negative regulator in the later stages in the hypertrophy of rat masseter muscle induced by clenbuterol, whereas IGF works as a positive regulator in the earlier stages. Copyright © 2012 John Wiley & Sons, Ltd.
Novel (Phenylethynyl)pyrene–LNA Constructs for Fluorescence SNP Sensing in Polymorphic Nucleic Acid Targets
Authors: Astakhova Irina Kira , Samokhina Evgeniya , Babu B. Ravindra , Wengel Jesper
Published: June 2012

We describe fluorescent oligonucleotide probes labeled with novel (phenylethynyl)pyrene dyes attached to locked nucleic acids. Furthermore, we prove the utility of these probes for the effective detection of single‐nucleotide polymorphisms in natural nucleic acids. High‐affinity hybridization of the probes and excellent fluorescence responses to single‐base mismatches in DNA/RNA targets are demonstrated in model dual‐probe and doubly labeled probe formats. This stimulated us to develop two diagnostic systems for the homogeneous detection of a drug‐resistance‐causing mutation in HIV‐1 protease cDNA and RNA gene fragments. Target sequences were obtained by analysis of 200 clinical samples from patients currently receiving anti‐HIV/AIDS combination therapy at the Russian Federal AIDS Center. Using these fluorescent oligonucleotides, we were able to detect the target mutation despite all the challenges of the natural targets, that is, the presence of additional mutations, neighboring sequence variation, and low target concentration, which typically reduce binding and effectiveness of sensing by fluorescent oligonucleotides.
The Butenolide Signaling Molecules SRB1 and SRB2 Induce Lankacidin and Lankamycin Production in Streptomyces rochei
Authors: Arakawa Kenji , Tsuda Naoto , Taniguchi Akihiro , Kinashi Haruyasu
Published: June 2012

New signaling molecules that induce lankacidin and lankamycin production in Streptomyces rochei were extracted from the culture filtrate and purified by Sephadex LH20 and silica gel chromatography with the help of bioassay. Chiral HPLC and ESI‐MS analyses indicated the presence of two active components—SRB1 and SRB2—and their molecular formulas were established to be C15H24O5 and C16H26O5, respectively. By extensive NMR analysis, SRB1 and SRB2 were determined to be 2‐(1′‐hydroxy‐6′‐oxo‐8′‐methylnonyl)‐3‐methyl‐4‐hydroxybut‐2‐en‐1,4‐olide and 2‐(1′‐hydroxy‐6′‐oxo‐8′‐methyldecyl)‐3‐methyl‐4‐hydroxybut‐2‐en‐1,4‐olide, respectively. These structures were finally confirmed by chemical synthesis and the absolute configuration at C‐1′ was determined to be R in each case. The synthetic 1′R isomers induced production of lankacidin and lankamycin at around 40 nM concentrations. SRB1 and SRB2 are therefore distinct from the well‐known 2,3‐disubstituted γ‐butyrolactone molecules such as A‐factor, virginia butanolide, and SCB1 and and belong, like avenolide, recently isolated from Streptomyces avermitilis, to the γ‐butenolide family.
ChemInform Abstract: Diverse Closed Cavities in Condensed Rare Earth Metal—Chalcogenide Matrixes: Cs[Lu7Q11] and (ClCs6)[RE21Q34] (RE: Dy, Ho; Q: S, Se, Te).
Authors: Lin Hua , Li Long‐Hua , Chen Ling
Published: June 2012

The title compounds are prepared by solid state reaction of CsCl, Ln (Ln: Dy, Ho, Lu), and the corresponding chalcogen (1223 K, 4—5 d).
ChemInform Abstract: Scandium as an Element Intermediate Between Rare Earth and Transition Metals in Intermetallics: Crystal Structures of Sc2Fe12P7, Sc3.6Fe10.4P7, and Sc2Co4P3. Other New Compounds with Zr2Fe12P7, Hf2Co4P3, Sc5Co19P12, and Yb6Co30P19 Type Structures.
Authors: Jeitschko Wolfgang , Meisen Ulrich , Reinbold Elke J.
Published: June 2012

Sc2Fe12P7, Sc3.6Fe10.4P7, Y2Co12P7, and Hf2M12P7 (M: Fe, Co, Ni) crystallize in the hexagonal space group P$\bar 6$ with Z = 1 (Zr2Fe12P7‐type structure; single crystal XRD data for Sc3.6Fe10.4P7).
ChemInform Abstract: Photochemistry of Tetrasulfur Tetranitride: Laser Flash Photolysis and Quantum Chemical Study.
Authors: Pritchina Elena A. , Terpilovskaya Daria S. , Tsentalovich Yuri P. , Platz Matthew S. , Gritsan Nina P.
Published: June 2012

The photochemistry of S4N4 with a highly symmetric cage structure is studied by laser flash photolysis and B3LYP quantum chemical computations.
ChemInform Abstract: Lewis Acid Base Reactions Between Boron Trifluoride and Complex Oxoanions as a Versatile Access to Fluorooxoanions: Synthesis of Sodium (Trifluoroborato)sulfate.
Authors: Pilz Thomas , Jansen Martin
Published: June 2012

Na2SO4BF3 is synthesized by reaction of gaseous BF3 (obtained by thermal decomposition of LiBF4) and solid Na2SO4 (sealed quartz ampule; 603 K, 300 h).
ChemInform Abstract: Ba2(BO3)1‐x (CO3)xCl1+x: A Mixed Borate and Carbonate Chloride Crystallized from High‐Temperature Solution.
Authors: Zhao Jing , Li R. K.
Published: June 2012

The title compound is prepared by spontaneous crystallization from a melt of BaCl2, BaCO3, and H3BO3 (Pt crucible, 970 °C, 24 h; controlled cooling).
ChemInform Abstract: Dimensional Reduction of a Layered Metal Chalcogenide into a 1D Near‐IR Direct Band Gap Semiconductor.
Authors: Liu Yi‐Hsin , Porter Spencer H. , Goldberger Joshua E.
Published: June 2012

TiS2(en) is synthesized by reaction of TiCl4 with elemental sulfur dissolved in excess en at room temperature in a N2 atmosphere, followed by annealing at 220 °C for 3—5 d in a Parr reactor.
ChemInform Abstract: Synthesis, Crystal Structure, Chemical Bonding, and Physical Properties of the Ternary Na/Mg Stannide Na2MgSn.
Authors: Yamada Takahiro , Deringer Volker L. , Dronskowski Richard , Yamane Hisanori
Published: June 2012

The title compound is prepared by solid state reaction of a stoichiometric mixture of the elements (1.
ChemInform Abstract: Molecular Magnetism of M6 Hexagon Ring in D3d Symmetric [(MCl)6(XW9O33)2]12‐ (M: CuII and MnII, X: SbIII and AsIII).
Authors: Yamase Toshihiro , Ishikawa Hirofumi , Abe Hiroko , Fukaya Keisuke , Nojiri Hiroyuki , Takeuchi Hideo
Published: June 2012

The ferromagnetic compound (III) and antiferromagnetic compound (VI) are characterized by single crystal XRD, ESR spectroscopy, and magnetic measurements.
ChemInform Abstract: Incorporating Rare Earth Metal Complexes and Conjugated Organic Cations into Polymeric Iodoargentate: Structures and Properties of Two Hybrid Iodoargentates.
Authors: Li Hao‐Hong , Huang Shu‐Wei , Lian Zhao‐Xun , Liu Ji‐Bo , Wang Min , Chen Zhi‐Rong
Published: June 2012

The structures of the new compounds (III) and (IV) are determined by single crystal XRD.
ChemInform Abstract: A Five‐Membered Ru5 Ring in a Hexagonal La14 Cage: The La14Cl20Ru5 Structure.
Authors: Zheng Chong , Koehler Juergen , Mattausch Hansjuergen , Hoch Constantin , Simon Arndt
Published: June 2012

The title compound is prepared from a stoichiometric mixture of La, LaCl3, and Ru (Ta tube, Ar, 880 °C, 20 d, <90% yield).
ChemInform Abstract: 2‐Trifluoromethyl‐2‐methyl‐4‐phenyloxazolidine: A New Chiral Auxiliary for Highly Diastereoselective Enolate Alkylation.
Authors: Tessier Arnaud , Pytkowicz Julien , Brigaud Thierry
Published: June 2012

The alkylation of the enolate of amide (I) bearing a new auxiliary proceeds in good yields and excellent diastereoselectivity (<98% d.e.).
ChemInform Abstract: Immobilization of Chiral Catalysts on Magnetite Nanoparticles for Highly Enantioselective Asymmetric Hydrogenation of Aromatic Ketones.
Authors: Hu Aiguo , Liu Sophie , Lin Wenbin
Published: June 2012

4,4′‐Bisphosphonic acid‐BINAP‐ruthenium catalyst DPR and 4,4′‐disilyl‐BINAP‐ruthenium catalyst DSR are prepared and tested in the title reaction.
ChemInform Abstract: Phosphine‐Catalyzed [4 + 2] Annulation and Vinylogous Addition Reactions Between 1,4‐Dien‐3‐ones and 1,1‐Dicyanoalkenes.
Authors: Zhou Rong , Wang Jianfang , Tian Junjun , He Zhengjie
Published: June 2012

[4 + 2] Annulation reactions of symmetrical ketones (I) with malononitrile derivatives (II) affords cyclohexanones (III) as major product.
ChemInform Abstract: Regioselective Photochemical Rearrangement of N‐Mesyloxylactams.
Authors: Pichette Simon , Aubert‐Nicol Samuel , Lessard Jean , Spino Claude
Published: June 2012

Photoinduced ring contraction of N‐mesyloxylactams in methanol mainly gives C‐3 migration products, e.g. (III), (VI), (VIII), (X) and (XIII).
ChemInform Abstract: Facile Preparation and Reactivity of Bifunctional Ionic Liquid Supported Hypervalent Iodine Reagent: A Convenient Recyclable Reagent for Catalytic Oxidation.
Authors: Zhu Chenjie , Yoshimura Akira , Wei Yunyang , Nemykin Victor N. , Zhdankin Viktor V.
Published: June 2012

TEMPO derivatives (I) and (II) are synthesized and successfully tested as recycable catalysts for the peracid oxidation of a broad spectrum of primary and secondary alcohols to the corresponding carbonyl compounds.
ChemInform Abstract: Guanidinium Chlorochromate, a New Efficient, and Mild Oxidizing Agent for Benzylic and Other Alcohols to Carbonyl Compounds in Water and Organic Solvents.
Authors: Goswami Shyamaprosad , Kar Arnab
Published: June 2012

The new oxidizing reagent is suitable for secondary and benzylic‐type alcohols.
ChemInform Abstract: Pd Nanoparticle Catalyzed One‐Pot Sequential Heck and Suzuki Couplings of Bromo‐Chloroarenes in Ionic Liquids and Water.
Authors: Cotugno Pietro , Monopoli Antonio , Ciminale Francesco , Cioffi Nicola , Nacci Angelo
Published: June 2012

Simple protocols are elaborated for the concise synthesis of different di‐ and trisubstituted arenes using a combination of Heck and/or Suzuki cross‐coupling reactions [27 examples].
ChemInform Abstract: Iron‐Catalyzed Nitrogen‐Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium.
Authors: Ilies Laurean , Kobayashi Motoaki , Matsumoto Arimasa , Yoshikai Naohiko , Nakamura Eiichi
Published: June 2012

2‐Arylpyridines, 2‐alkenylpyridine, and aromatic imines undergo regioselective oxidative coupling using 1,2‐dichloro‐2‐methylpropane as an oxidant.
ChemInform Abstract: An Efficient and Practical Protocol for Catalytic Hydrolysis of Nitriles by a Copper(I) Complex in Water.
Authors: Li Zhengkai , Wang Lixia , Zhou Xiangge
Published: June 2012

The tetranuclear Cu complex can be recovered and reused five times without loss of activity and it can be applied to large‐scale reactions (100g PhCN).
ChemInform Abstract: Mild, Efficient, and Greener Dethioacetalization Protocol Using 30% Hydrogen Peroxide in Catalytic Combination with Ammonium Iodide.
Authors: Ganguly Nemai C. , Mondal Pallab
Published: June 2012

The new dethioacetalization protocol developed is compatible with various acid‐sensitive protecting groups such as silyl ether, acetates, ‐NH‐Boc and ‐NH‐Bn.
ChemInform Abstract: New Method for C—H Arylation/Alkylation at α‐Position of Cyclic Aliphatic Ethers by Iron‐Oxide Mediated Reaction.
Authors: Singh Parvinder Pal , Gudup Satish , Aruri Hariprasad , Singh Umed , Ambala Srinivas , Yadav Mahipal , Sawant Sanghapal D. , Vishwakarma Ram A.
Published: June 2012

The title method is performed with THF, tetrahydropyran, and 2‐methyltetrahydrofuran, and freshly prepared aryl/alkylmagnesium halides or organolithium compounds.
ChemInform Abstract: Palladium‐Catalyzed Cross‐Coupling Reactions of Organogold(I) Phosphanes with Allylic Electrophiles.
Authors: Pena‐Lopez Miguel , Ayan‐Varela Miguel , Sarandeses Luis A. , Perez Sestelo Jose
Published: June 2012

The title reaction of aryl‐ or alkenylgold phosphane complexes (II) with allylic chlorides, bromides or acetates proceeds with high regioselectivity (γ‐products are not detected).
ChemInform Abstract: Copper‐Free Asymmetric Allylic Alkylation Using Grignard Reagents on Bifunctional Allylic Bromides.
Authors: Grassi David , Alexakis Alexandre
Published: June 2012

Various aromatic and aliphatic substrates containing a vinylic bromide unity are alkylated with Grignards reagents to afford the products with good enantio‐ and regioselectivities.
ChemInform Abstract: N‐Heterocyclic Carbene‐Mediated Hydroacylation—Sonogashira/Heck/Suzuki Coupling in a Single Pot: A New Cascade Reaction.
Authors: Sreenivasulu M. , Kumar K. Siva , Kumar P. Rajender , Chandrasekhar K. B. , Pal Manojit
Published: June 2012

The hydroacylation of α‐keto esters (I) with o‐, m‐, or p‐iodobenzaldehydes (II) and the subsequent palladium‐catalyzed cross‐coupling reactions with terminal alkynes, alkenes, or boronic acids is successfully performed in the same pot using an optimized N‐heterocyclic carbene ligand.
ChemInform Abstract: N‐Heterocyclic Carbene Catalyzed Internal Redox Reaction of Alkynals: An Efficient Synthesis of Allenoates.
Authors: Zhao Yu‐Ming , Tam Yik , Wang Yu‐Jie , Li Zigang , Sun Jianwei
Published: June 2012

The desired allene products are obtained in good to excellent yields in the presence of MeOH including an asymmetric version for (IIIa).
ChemInform Abstract: Pd‐Catalyzed Direct Arylation of Polyfluoroarenes on Water under Mild Conditions Using PPh3 Ligand.
Authors: Chen Fei , Min Qiao‐Qiao , Zhang Xingang
Published: June 2012

The methodology allows an efficient access to a broad spectrum of highly fluorinated polyaryls which are of interest in material and life science.
ChemInform Abstract: Iterative Asymmetric Allylic Substitutions: syn‐ and anti‐1,2‐Diols Through Catalyst Control.
Authors: Park Jin Kyoon , McQuade D. Tyler
Published: June 2012

Catalyst (I) and its enantiomer (II) are used for the selective synthesis of the title compounds as subunits of natural compounds.
ChemInform Abstract: Rhodium‐Catalyzed Carbonylation of 3‐Acyloxy‐1,4‐enynes for the Synthesis of Cyclopentenones.
Authors: Li Xiaoxun , Huang Suyu , Schienebeck Casi M. , Shu Dongxu , Tang Weiping
Published: June 2012

A wide range of cyclopentenes is prepared involving a Saucy—Marbet 1,3‐acyloxy migration of propargyl esters and [4 + 1]‐cycloaddition/carbonylation of the resulting vinylallene.
ChemInform Abstract: Arylsulfonylacetylenes as Alkynylating Reagents of Csp2—H Bonds Activated with Lithium Bases.
Authors: Garcia Ruano Jose Luis , Aleman Jose , Marzo Leyre , Alvarado Cuauhtemoc , Tortosa Mariola , Diaz‐Tendero Sergio , Fraile Alberto
Published: June 2012

A novel strategy for the alkynylation of arenes, hetarenes, and a vinyl iodide uses activation of C—H bonds by lithiation followed by an anti‐Michael addition of 2‐aryl‐ and 2‐Tips‐substituted sulfonylacetylenes.
ChemInform Abstract: Ionic Liquids as New Media for Electrophilic Trifluoromethylation Reactions.
Authors: Pegot Bruce , Mace Yohan , Urban Celine , Diter Patrick , Blazejewski Jean‐Claude , Magnier Emmanuel
Published: June 2012

The electrophilic trifluoromethylation of aniline with sulfonium salts like (II) proceeds efficiently in [bdmim]BF4 as solvent.
ChemInform Abstract: 2‐(Diphenylphosphino)benzoyl‐Substituted Calix[4]arene: Efficient Organocatalyst in Aza‐Morita—Baylis—Hillman Reaction of N‐Sulfonated Imines with Methyl Vinyl Ketone.
Authors: Shen Yanyan , Tang Qian , Zhang Chenchen , Zhong Weihui
Published: June 2012

The calixarene shows high stability towards oxidation and can be reused 5 times without significant loss of catalytic activity.
ChemInform Abstract: Friedel—Crafts‐Type Allylation of Nitrogen‐Containing Aromatic Compounds with Allylic Alcohols Catalyzed by a [Mo3S4Pd(η3‐allyl)] Cluster.
Authors: Tao Yinsong , Wang Baomin , Zhao Jinfeng , Song Yuming , Qu Lihong , Qu Jingping
Published: June 2012

The Mo cluster efficiently promotes the reaction of dialkylanilines and indoles with allylic alcohols.
ChemInform Abstract: Asymmetric Allylboration of Aldehydes with Pinacol Allylboronates Catalyzed by 1,1′‐Spirobiindane‐7,7′‐diol (SPINOL) Based Phosphoric Acids.
Authors: Xing Chun‐Hui , Liao Yuan‐Xi , Zhang Yimei , Sabarova Darya , Bassous Monica , Hu Qiao‐Sheng
Published: June 2012

The reaction results in formation of optically active homoallylic alcohols.
ChemInform Abstract: One‐Pot β‐Alkylation of Secondary Alcohols with Primary Alcohols Catalyzed by Ruthenacycles.
Authors: Chang Xu , Chuan Low Wei , Yongxin Li , Pullarkat Sumod A.
Published: June 2012

A catalyst screening reveals that ruthenacycle RUC exhibits excellent activity and product selectivity to give β‐alkylated alcohols and ketones.
ChemInform Abstract: Base‐Catalyzed Direct Transformation of Benzylamines into Benzyl Alcohols.
Authors: Kanbara Yutaka , Abe Takafumi , Fushimi Norio , Ikeno Taketo
Published: June 2012

Treatment of benzylamines with NaOH in superheated aqueous methanol results in direct formation of benzyl alcohols in high yields.
ChemInform Abstract: HF—Pyridine: A Versatile Promoter for Monoacylation/Sulfonylation of Phenolic Diols and for Direct Conversion of t‐Butyldimethylsilyl Ethers to the Corresponding Acetates.
Authors: Michigami Kyosuke , Yoshimoto Kazuya , Hayashi Masahiko
Published: June 2012

The use of HF—pyridine as a promoter in the acylation of phenolic diols predominantly yields the monoprotected diols, in contrast to the use of pyridine alone which promotes diprotection.
ChemInform Abstract: Ligand‐Free, Highly Efficient Synthesis of Diaryl Ether over Copper Fluorapatite as Heterogeneous Reusable Catalyst.
Authors: Mulla Shafeek A. R. , Inamdar Suleman M. , Pathan Mohsinkhan Y. , Chavan Santosh S.
Published: June 2012

The method is highly effective for the coupling of aryl bromides or iodides and potassium salts of phenols (yield < 80%).
ChemInform Abstract: syn‐Selective Vinylogous Kobayashi Aldol Reaction.
Authors: Symkenberg Gerrit , Kalesse Markus
Published: June 2012

The reaction of (1E,3Z) ketene N,O‐acetal (I) with various aldehydes proceeds with complete syn‐selectivity to afford products with aliphatic, aromatic and unsaturated substituents.
ChemInform Abstract: Enantioselective Iridium‐Catalyzed Hydrogenation of β,γ‐Unsaturated Carboxylic Acids: An Efficient Approach to Chiral 4‐Alkyl‐4‐aryl Butanoic Acids.
Authors: Song Song , Zhu Shou‐Fei , Yang Shuang , Li Shen , Zhou Qi‐Lin
Published: June 2012

Among various spiro iridium complexes tested, (I) is found to be the optimal catalyst.
ChemInform Abstract: Sequential Allylic C—H Amination/Vinylic C—H Arylation: A Strategy for Unnatural Amino Acid Synthesis from α‐Olefins.
Authors: Jiang Chao , Covell Dustin J. , Stepan Antonia F. , Plummer Mark S. , White M. Christina
Published: June 2012

The products are formed as (E)‐configurated single regioisomers.
ChemInform Abstract: Synthesis of γ,δ‐Unsaturated Quaternary α‐Alkylamino Acids Using Umpolung Reaction and Claisen Rearrangement.
Authors: Mizota Isao , Tanaka Katsuki , Shimizu Makoto
Published: June 2012

Claisen rearrangement of substrates of type (I) and (V) with a reagent mixture Et2AlCl/EtAlCl2 offers an interesting synthesis of the target compounds which are isolated as methyl esters after hydrolytic work‐up.
ChemInform Abstract: Asymmetric Addition of Arylboronic Acids to Glyoxylate Catalyzed by a Ruthenium/Me‐BIPAM Complex.
Authors: Yamamoto Yasunori , Shirai Tomohiko , Miyaura Norio
Published: June 2012

The enantioselective synthesis of α‐hydroxy esters (III) by Ru‐catalyzed 1,2‐addition of arylboronic acids (II) to tert‐butyl glyoxylates (I) is described.
ChemInform Abstract: Enantioselective Trapping of an α‐Chiral Carbanion of Acyclic Nitrile by a Carbon Electrophile.
Authors: Sasaki Michiko , Takegawa Tomo , Ikemoto Hidaka , Kawahata Masatoshi , Yamaguchi Kentaro , Takeda Kei
Published: June 2012

α‐Chiral nitrile carbanions generated by deprotonation of enantioenriched O‐carbamoyl cyanohydrins (I) are trapped in situ with ethyl cyanoformate (II) to give corresponding ester derivatives (III) in high yields and good enantioselectivity.
ChemInform Abstract: Efficient Palladium‐Catalyzed Selective Synthesis of Benzenesulfonic Acids.
Authors: Jagadeesh Rajenahally V. , Sandhya Y. Sree , Karthikeyan P. , Reddy S. Sudhakar , Reddy P. Pradeep Kumar , Kumar M. Viniod , Charan K. T. Prabhu , Narender R. , Bhagat P. R.
Published: June 2012

The 2‐aminobenzenesulfonic acids (II) are efficiently obtained from benzothiazoles (I) using chloramine‐B in the presence of a Pd‐catalyst under alkaline conditions.
ChemInform Abstract: A Mild and Efficient Protocol for Oxidation of Thiols to Disulfides in Water
Authors: Dewan Anindita , Bora Utpal , Kakati Dilip K.
Published: June 2012

using a vanadium polyoxometalate as catalyst
ChemInform Abstract: In situ Electrogeneration of o‐Benzoquinone and High Yield Reaction with Benzenethiols in a Microflow System.
Authors: Kashiwagi Tsuneo , Amemiya Fumihiro , Fuchigami Toshio , Atobe Mahito
Published: June 2012

Key features of the method described are an effective electrochemical o‐benzoquinone generation and its rapid use for the following thiol addition without decomposition in a microflow system.
ChemInform Abstract: Solvent‐Free Conversion of Thioamides to Thioesters.
Authors: Boeini Hassan Zali , Zali Abbas
Published: June 2012

The environmentally benign reaction, leading to thioesters (III) and (V), profits from the use of cheap and safe materials and avoids the use of very unpleasant and noxious thiols as well as corrosive acid chlorides.
ChemInform Abstract: Metal‐Free, One‐Pot Highly Selective Synthesis of (E)‐Vinyl Sulfones and Sulfoxides via Addition—Oxidation of Thiols with Alkynes.
Authors: Xue Qicai , Mao Zhijie , Shi Yan , Mao Haibin , Cheng Yixiang , Zhu Chengjian
Published: June 2012

The course of the reaction depends on the temperature.
ChemInform Abstract: An Alternative Approach to para‐C—H Arylation of Phenol: Palladium‐Catalyzed Tandem γ‐Arylation/Aromatization of 2‐Cyclohexen‐1‐one Derivatives.
Authors: Imahori Tatsushi , Tokuda Toru , Taguchi Tatsuya , Takahata Hiroki
Published: June 2012

The sequence can be applied to various cyclohexenones and aryl bromides.
ChemInform Abstract: Homo‐ and Heterooxidative Coupling of Benzyl Anions.
Authors: Blangetti Marco , Fleming Patricia , O'Shea Donal F.
Published: June 2012

A facile method to prepare various 1,2‐diarylethanes is reported.
ChemInform Abstract: Cu‐Promoted [2 + 2] Cycloaddition of 1,4‐Bisallenes.
Authors: Kitagaki Shinji , Kajita Mikihito , Narita Syu , Mukai Chisato
Published: June 2012

The desired cycloadducts are formed together with low amounts of tetraenes.
ChemInform Abstract: Mild Copper‐Catalyzed Trifluoromethylation of Terminal Alkynes Using an Electrophilic Trifluoromethylating Reagent.
Authors: Weng Zhiqiang , Li Huaifeng , He Weiming , Yao Liang‐Feng , Tan Jianwei , Chen Jinfa , Yuan Yaofeng , Huang Kuo‐Wei
Published: June 2012

The title reaction tolerates a variety of functional groups.
ChemInform Abstract: Nano‐Sulfated Zirconia as an Efficient, Recyclable and Environmentally Benign Catalyst for One‐Pot Three‐Component Synthesis of Amidoalkyl Naphthols.
Authors: Zali Abbas , Shokrolahi Arash
Published: June 2012

The target compounds, important intermediates in the preparation of bioactive components, are readily available under solvent‐free conditions within a short time.
ChemInform Abstract: Double 1,4‐Rhodium Migration Cascade in Rhodium‐Catalyzed Arylative Ring‐Opening/Spirocyclization of (3‐Arylcyclobutylidene)acetates.
Authors: Matsuda Takanori , Suda Yuya , Takahashi Akira
Published: June 2012

A catalytic spirocyclization is described forming 1,1′‐spirobiindan‐3‐ones (III), (V), (VII), and (IX) via a 1,4‐rhodium migration cascade.