bluuebunny/crossref_metadata_2025 huggingface dataset:
Evolution in Time of Radiation Defects Induced by Negative Pions and Muons in Crystals with a Diamond Structure
Authors: Belousov Yury
Published: June 2017

Evolution in time of radiation defects induced by negatively-charged pions and muons in crystals with diamond structures is considered. Negative pions and muons are captured by the nucleus and ionize an appropriate host atom, forming a positively-charged radiation defect in a lattice. As a result of an evolution in time, this radiation defect transforms into the acceptor center. An analysis of the full evolution process is considered for the first time. Formation of this acceptor center can be divided into three stages. At the first stage, the radiation defect interacts with a radiation trace and captures electrons. The radiation defect is neutralized completely in Si and Ge for a short time t ≤ 10 − 11 s, but in diamond, the complete neutralization time is very large t ≥ 10 − 6 s. At the second stage, broken chemical bonds of the radiation defect are restored. In Si and Ge, this process takes place for the neutral radiation defect, but in diamond, it goes for a positively-charged state. The characteristic time of this stage is t < 10 − 8 s for Si and Ge and t < 10 − 11 s for diamond. After the chemical bonds’ restoration, the positively-charged, but chemically-bound radiation defect in diamond is quickly neutralized because of the electron density redistribution. The neutralization process is characterized by the lattice relaxation time. At the third stage, a neutral chemically-bound radiation defect captures an additional electron to saturate all chemical bonds and forms an ionized acceptor center. The existence of a sufficiently big electric dipolar moment leads to the electron capture. Qualitative estimates for the time of this process were obtained for diamond, silicon and germanium crystals. It was sown that this time is the shortest for diamond (≤ 10 − 8 s) and the longest for silicon (≤ 10 − 7 s)
Remote System Update for System on Programmable Chip Based on Controller Area Network
Authors: Zhou Lei , Liu Qingxiang , Wang Bangji , Yang Peixin , Li Xiangqiang , Zhang Jianqiong
Published: June 2017

In some application domains, using a download cable to update the system on a programmable chip (SoPC) is infeasible, which reduces the maintainability and flexibility of the system. Hence the remote system update (RSU) scheme is being studied. In this scheme, the serial configuration (EPCS) device involves a factory mode configuration image, which acts as the baseline, and an application mode configuration image, which is used for some specific functions. Specifically, a new application mode image is delivered through the controller area network (CAN) with the improved application layer protocol. Besides, the data flow and data check for transmitting a new image are constructed to combine the transmission reliability with efficiency. The boot sequence copying hardware configuration code and software configuration code is analyzed, and the advanced boot loader is carried out to specify boot address of the application mode image manually. Experiments have demonstrated the feasibility of updating and running a new application mode image, as well as rolling back into the factory mode image when no application mode image is available. This scheme applies a single CAN bus, which makes the system easy to construct and suitable for the field distributed control system.
Carbon Stocks across a Fifty Year Chronosequence of Rubber Plantations in Tropical China
Authors: Liu Chenggang , Pang Jiaping , Jepsen Martin , Lü Xiaotao , Tang Jianwei
Published: June 2017

Transition from forest to rubber (Hevea brasiliensis Muell. Arg.) plantation has occurred in tropical China for decades. Rubber has been planted on 1 million ha to provide raw materials to the rubber industry. The role of various-aged rubber plantations in carbon (C) sequestration remains unclear. The biomass C accumulation including latex C and C distribution in soil of five different-aged stands (7, 13, 19, 25 and 47 years old) were examined. The total biomass C stock (TBC) and total net primary productivity (NPPtotal), whether with or without latex C, had a close quadratic relationship with stand age. Regardless of stand age, around 68% of the C was stored in aboveground biomass, and NPPlatex contributed to approximately 18% of C sequestration. Soil organic carbon stock in the 100-cm depth remained relatively stable, but it lost about 16.8 Mg ha−1 with stand age. The total ecosystem C stock (TEC) across stands averaged 159.6, 174.4, 229.6, 238.1 and 291.9 Mg ha−1, respectively, of which more than 45% was stored in the soil. However, biomass would become the major C sink rather than soil over a maximal rubber life expectancy. Regression analysis showed that TEC for rubber plantation at 22 years is comparable to a baseline of 230.4 Mg ha−1 for tropical forest in China, and would reach the maximum value at around 54 years. Therefore, rubber plantation can be considered as alternative land use without affecting net forest ecosystem C storage. In addition to the potential C gains, a full set of ecosystem and economic properties have to be quantified in order to assess the trade-offs associated with forest-to-rubber transition.
Stress Coefficients for Soil Water Balance Combined with Water Stress Indicators for Irrigation Scheduling of Woody Crops
Authors: Ferreira Maria
Published: June 2017

There are several causes for the failure of empirical models to estimate soil water depletion and to calculate irrigation depths, and the problem is particularly critical in tall, uneven, deficit irrigated (DI) crops in Mediterranean climates. Locally measured indicators that quantify water status are useful for addressing those causes and providing feed-back information for improving the adequacy of simple models. Because of their high aerodynamic resistance, the canopy conductance of woody crops is an important factor in determining evapotranspiration (ET), and accurate stress coefficient (Ks) values are needed to quantify the impact of stomatal closure on ET. A brief overview of basic general principles for irrigation scheduling is presented with emphasis on DI applications that require Ks modelling. The limitations of existing technology related to scheduling of woody crops are discussed, including the shortcomings of plant-based approaches. In relation to soil water deficit and/or predawn leaf water potential, several woody crop Ks functions are presented in a secondary analysis. Whenever the total and readily available water data were available, a simple Ks model was tested. The ultimate aim of this discussion is to illustrate the central concept: that a combination of simple ET models and water stress indicators is required for scheduling irrigation of deep-rooted woody crops.
Associations of Community Water Fluoridation with Caries Prevalence and Oral Health Inequality in Children
Authors: Kim Han-Na , Kim Jeong-Hee , Kim Se-Yeon , Kim Jin-Bom
Published: June 2017

This study aimed to confirm the association between the community water fluoridation (CWF) programme and dental caries prevention on permanent teeth, comparing to a control area, neighbouring population without the programme, and verifying whether the programme can reduce the socio-economic inequality related to the oral health of children in Korea. Evaluation surveys were conducted among 6-, 8-, and 11-year-old children living in Okcheon (CWF) and neighbouring Yeongdong (non-CWF, control area) towns in South Korea. Data on monthly family income, caregiver educational level, and Family Affluence Scale scores were evaluated using questionnaires that were distributed to the parents. The effectiveness of CWF in caries reduction was calculated based on the differences in decayed, missing, and filled teeth and decayed, missing, and filled tooth surfaces indices between the two towns. The data were analysed using logistic regression and univariate analysis of variance. Both 8- and 11-year-old children living in the CWF area had lower dental caries prevalence than those living in the non-CWF community. Differences in dental caries prevalence based on educational level were found in the control area but not in the CWF area. Socio-economic factor-related inequality in oral health were observed in the non-CWF community. Additionally, 8- and 11-year-old children living in the CWF area displayed lower dental caries prevalence in the pit-and-fissure and smooth surfaces than those living in the non-CWF community. These results suggest that CWF programmes are effective in the prevention of caries on permanent teeth and can reduce oral health inequalities among children. The implementation of CWF programmes should be sustained to overcome oral health inequalities due to socio-economic factors and improve children’s overall oral health.
Occurrence, Toxicity, and Analysis of Major Mycotoxins in Food
Authors: Alshannaq Ahmad , Yu Jae-Hyuk
Published: June 2017

Mycotoxins are toxic secondary metabolites produced by certain filamentous fungi (molds). These low molecular weight compounds (usually less than 1000 Daltons) are naturally occurring and practically unavoidable. They can enter our food chain either directly from plant-based food components contaminated with mycotoxins or by indirect contamination from the growth of toxigenic fungi on food. Mycotoxins can accumulate in maturing corn, cereals, soybeans, sorghum, peanuts, and other food and feed crops in the field and in grain during transportation. Consumption of mycotoxin-contaminated food or feed can cause acute or chronic toxicity in human and animals. In addition to concerns over adverse effects from direct consumption of mycotoxin-contaminated foods and feeds, there is also public health concern over the potential ingestion of animal-derived food products, such as meat, milk, or eggs, containing residues or metabolites of mycotoxins. Members of three fungal genera, Aspergillus, Fusarium, and Penicillium, are the major mycotoxin producers. While over 300 mycotoxins have been identified, six (aflatoxins, trichothecenes, zearalenone, fumonisins, ochratoxins, and patulin) are regularly found in food, posing unpredictable and ongoing food safety problems worldwide. This review summarizes the toxicity of the six mycotoxins, foods commonly contaminated by one or more of them, and the current methods for detection and analysis of these mycotoxins.
The Recreovía of Bogotá, a Community-Based Physical Activity Program to Promote Physical Activity among Women: Baseline Results of the Natural Experiment Al Ritmo de las Comunidades
Authors: Sarmiento Olga , Rios Ana , Paez Diana , Quijano Karoll , Fermino Rogério
Published: June 2017

Community-based physical activity (PA) programs in Latin America have been recognized because of the use of available environmental resources to offer PA classes. Yet, the evaluation of programs focused on PA classes involving dancing in public spaces is limited. The aim of this study was to assess the physical activity levels, park use, and the contextual characteristics of public parks with and without the Recreovía in Bogotá in Colombia. Al Ritmo de las Comunidades is a natural experiment conducted in nine parks (3 parks implementing new Recreovías, 3 control parks and 3 parks with existing Recreovías) during 2013. We used the System for Observing Play and Recreation in Communities to evaluate park use (gender, age, and physical activity level) and target areas. A total of 4925 people were observed during 702 observation visits to parks. The percentage of women was higher in parks with Recreovía, compared to parks without Recreovía (53% vs. 40% vs. 33%; p < 0.001). Women using parks with Recreovía compared to women in parks without Recreovía were less likely to be sedentary (25% vs. 39%; p < 0.0001) and more likely to engage in moderate-to-vigorous activity (75% vs. 61%; p < 0.0001). Among men, the activity pattern was the opposite. The Recreovía is a promising strategy to promote park use and PA, especially among women who are less likely to meet PA recommendations during their leisure time. The provision of a cost-free community program may be an effective approach and a good investment for health.
Dissemination of Chronic Disease Self-Management Education (CDSME) Programs in the United States: Intervention Delivery by Rurality
Authors: Smith Matthew , Towne Samuel , Herrera-Venson Angelica , Cameron Kathleen , Kulinski Kristie , Lorig Kate , Horel Scott , Ory Marcia
Published: June 2017

Background: Alongside the dramatic increase of older adults in the United States (U.S.), it is projected that the aging population residing in rural areas will continue to grow. As the prevalence of chronic diseases and multiple chronic conditions among adults continues to rise, there is additional need for evidence-based interventions to assist the aging population to improve lifestyle behaviors, and self-manage their chronic conditions. The purpose of this descriptive study was to identify the geospatial dissemination of Chronic Disease Self-Management Education (CDSME) Programs across the U.S. in terms of participants enrolled, workshops delivered, and counties reached. These dissemination characteristics were compared across rurality designations (i.e., metro areas; non-metro areas adjacent to metro areas, and non-metro areas not adjacent to metro areas). Methods: This descriptive study analyzed data from a national repository including efforts from 83 grantees spanning 47 states from December 2009 to December 2016. Counts were tabulated and averages were calculated. Results: CDSME Program workshops were delivered in 56.4% of all U.S. counties one or more times during the study period. Of the counties where a workshop was conducted, 50.5% were delivered in non-metro areas. Of the 300,640 participants enrolled in CDSME Programs, 12% attended workshops in non-metro adjacent areas, and 7% attended workshops in non-metro non-adjacent areas. The majority of workshops were delivered in healthcare organizations, senior centers/Area Agencies on Aging, and residential facilities. On average, participants residing in non-metro areas had better workshop attendance and retention rates compared to participants in metro areas. Conclusions: Findings highlight the established role of traditional organizations/entities within the aging services network, to reach remote areas and serve diverse participants (e.g., senior centers). To facilitate growth in rural areas, technical assistance will be needed. Additional efforts are needed to bolster partnerships (e.g., sharing resources and knowledge), marketing (e.g., tailored material), and regular communication among stakeholders.
An Evaluation of the Proposed Worker Protection Standard with Respect to Pesticide Exposure and Parkinson’s Disease
Authors: Sparling Alica , Martin David , Posey Lillian
Published: June 2017

Citing a lack of information, the U.S. Environmental Protection Agency prudently did not account for the benefits of averting many chronic diseases in analyzing the Worker Protection Standards (WPS) revisions. We demonstrate that sufficient information can exist, using the example of the benefits to agricultural workers of reduced Parkinson’s disease (PD) due to reduced pesticide exposure. We define the benefits as the monetary value gained by improving quality of lives of people who would otherwise develop PD, plus the value of medical care cost averted and income not lost due to being healthy. For estimation, we use readily available parameters and obtain odds ratios of developing PD by conducting a meta-analysis of studies linking pesticide exposure to PD. The sensitivity analysis varies the number of agricultural workers affected by the regulation, the probability of being diagnosed with PD, the measurement and the timing of the benefits. Our initial assessment is that the reduced PD benefits would be a small fraction of the total WPS revision costs. However, if we define benefits as the common environmental economics willingness to pay to avoid PD incidence, then they become a substantial fraction of the costs. Our analysis demonstrates that the benefits of averting PD from the WPS revisions can be estimated using existing information, and that the results are most sensitive to the choice of valuation of benefits to the worker. We encourage other researchers to extend our framework to other chronic ailments.
Morphing of Building Footprints Using a Turning Angle Function
Authors: Li Jingzhong , Li Xingong , Xie Tian
Published: June 2017

We study the problem of morphing two polygons of building footprints at two different scales. This problem frequently occurs during the continuous zooming of interactive maps. The ground plan of a building footprint on a map has orthogonal characteristics, but traditional morphing methods cannot preserve these geographic characteristics at intermediate scales. We attempt to address this issue by presenting a turning angle function-based morphing model (TAFBM) that can generate polygons at an intermediate scale with an identical turning angle for each side. Thus, the orthogonal characteristics can be preserved during the entire interpolation. A case study demonstrates that the model yields good results when applied to data from a building map at various scales. During the continuous generalization, the orthogonal characteristics and their relationships with the spatial direction and topology are well preserved.
The Therapeutic Potential of Anti-Inflammatory Exerkines in the Treatment of Atherosclerosis
Authors: Yu Megan , Tsai Sheng-Feng , Kuo Yu-Min
Published: June 2017

Although many cardiovascular (CVD) medications, such as antithrombotics, statins, and antihypertensives, have been identified to treat atherosclerosis, at most, many of these therapeutic agents only delay its progression. A growing body of evidence suggests physical exercise could be implemented as a non-pharmacologic treatment due to its pro-metabolic, multisystemic, and anti-inflammatory benefits. Specifically, it has been discovered that certain anti-inflammatory peptides, metabolites, and RNA species (collectively termed “exerkines”) are released in response to exercise that could facilitate these benefits and could serve as potential therapeutic targets for atherosclerosis. However, much of the relationship between exercise and these exerkines remains unanswered, and there are several challenges in the discovery and validation of these exerkines. This review primarily highlights major anti-inflammatory exerkines that could serve as potential therapeutic targets for atherosclerosis. To provide some context and comparison for the therapeutic potential of exerkines, the anti-inflammatory, multisystemic benefits of exercise, the basic mechanisms of atherosclerosis, and the limited efficacies of current anti-inflammatory therapeutics for atherosclerosis are briefly summarized. Finally, key challenges and future directions for exploiting these exerkines in the treatment of atherosclerosis are discussed.
Expression of Salivary miR-203a-3p Was Related with Oral Health-Related Quality of Life in Healthy Volunteers
Authors: Kobayashi Terumasa , Tomofuji Takaaki , Machida Tatsuya , Yoneda Toshiki , Ekuni Daisuke , Azuma Tetsuji , Maruyama Takayuki , Hirose Akiko , Morita Manabu
Published: June 2017

Oral health-related quality of life (OHRQoL) is a multidimensional construct that involves subjective evaluation of an individual’s oral health. Although it is difficult to evaluate OHRQoL biologically, recently, it has been reported that circulating microRNAs (miRNAs) in several body fluids could reflect various health conditions. The aim of this pilot study was to investigate whether salivary miRNAs expression differs according to OHRQoL in healthy volunteers. Forty-six volunteers (median age, 23.0 years) were recruited, and their OHRQoL was assessed using the Japanese version of the Oral Health Impact Profile (OHIP-J). Then, we compared salivary microRNA profiles of the high-OHRQoL group (≤25th percentile score of OHIP-J) and the low-OHRQoL group (≥75th percentile score of OHIP-J) using the polymerase chain reaction (PCR) array and the quantitative real-time PCR. There were no significant differences between the two groups in terms of oral health status. In the PCR array, miR-203a-3p and miR-30b-5p were significantly more expressed in the low-OHRQoL group (p < 0.05). Quantitative real-time PCR assay also showed that miR-203a-3p was more highly expressed in the low-OHRQoL group than in the high-OHRQoL group (p < 0.05). These observations suggest that expression of salivary miR-203a-3p was related with OHRQoL in healthy volunteers.
Quantification of Bone Fatty Acid Metabolism and Its Regulation by Adipocyte Lipoprotein Lipase
Authors: Bartelt Alexander , Koehne Till , Tödter Klaus , Reimer Rudolph , Müller Brigitte , Behler-Janbeck Friederike , Heeren Joerg , Scheja Ludger , Niemeier Andreas
Published: June 2017

Adipocytes are master regulators of energy homeostasis. Although the contributions of classical brown and white adipose tissue (BAT and WAT, respectively) to glucose and fatty acid metabolism are well characterized, the metabolic role of adipocytes in bone marrow remains largely unclear. Here, we quantify bone fatty acid metabolism and its contribution to systemic nutrient handling in mice. Whereas in parts of the skeleton the specific amount of nutrients taken-up from the circulation was lower than in other metabolically active tissues such as BAT or liver, the overall contribution of the skeleton as a whole organ was remarkable, placing it among the top organs involved in systemic glucose as well as fatty acid clearance. We show that there are considerable site-specific variations in bone marrow fatty acid composition throughout the skeleton and that, especially in the tibia, marrow fatty acid profiles resemble classical BAT and WAT. Using a mouse model lacking lipoprotein lipase (LPL), a master regulator of plasma lipid turnover specifically in adipocytes, we show that impaired fatty acid flux leads to reduced amounts of dietary essential fatty acids while there was a profound increase in de novo produced fatty acids in both bone marrow and cortical bone. Notably, these changes in fatty acid profiles were not associated with any gross skeletal phenotype. These results identify LPL as an important regulator of fatty acid transport to skeletal compartments and demonstrate an intricate functional link between systemic and skeletal fatty acid and glucose metabolism.
CRISPR/Cas9-Mediated Correction of the FANCD1 Gene in Primary Patient Cells
Authors: Skvarova Kramarzova Karolina , Osborn Mark , Webber Beau , DeFeo Anthony , McElroy Amber , Kim Chong , Tolar Jakub
Published: June 2017

Fanconi anemia (FA) is an inherited condition characterized by impaired DNA repair, physical anomalies, bone marrow failure, and increased incidence of malignancy. Gene editing holds great potential to precisely correct the underlying genetic cause such that gene expression remains under the endogenous control mechanisms. This has been accomplished to date only in transformed cells or their reprogrammed induced pluripotent stem cell counterparts; however, it has not yet been reported in primary patient cells. Here we show the ability to correct a mutation in Fanconi anemia D1 (FANCD1) primary patient fibroblasts. The clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 system was employed to target and correct a FANCD1 gene deletion. Homologous recombination using an oligonucleotide donor was achieved and a pure population of modified cells was obtained by using inhibitors of poly adenosine diphosphate-ribose polymerase (poly ADP-ribose polymerase). FANCD1 function was restored and we did not observe any promiscuous cutting of the CRISPR/Cas9 at off target sites. This consideration is crucial in the context of the pre-malignant FA phenotype. Altogether we show the ability to correct a patient mutation in primary FANCD1 cells in a precise manner. These proof of principle studies support expanded application of gene editing for FA.
Turbo Coded OFDM Combined with MIMO Antennas Based on Matched Interleaver for Coded-Cooperative Wireless Communication
Authors: Umar Rahim , Yang Fengfan , Mughal Shoaib
Published: June 2017

A turbo coded cooperative orthogonal frequency division multiplexing (OFDM) with multiple-input multiple-output (MIMO) antennas scheme is considered, and its performance over a fast Rayleigh fading channel is evaluated. The turbo coded OFDM incorporates MIMO (2 × 2) Alamouti space-time block code. The interleaver design, and its placement always plays a vital role in the performance of a turbo coded cooperation scheme. Therefore, a code-matched interleaver (CMI) is selected as an optimum choice of interleaver and is placed at the relay node. The performance of the CMI is evaluated in a turbo coded OFDM system over an additive white Gaussian noise (AWGN) channel. Moreover, the performance of the CMI is also evaluated in the turbo coded OFDM system with MIMO antennas over a fast Rayleigh fading channel. The modulation schemes chosen are Binary Phase shift keying (BPSK), Quadrature phase shift keying (QPSK) and 16-Quadrature amplitude modulation (16QAM). Soft-demodulators are employed along with joint iterative soft-input soft-output (SISO) turbo decoder at the destination node. Monte Carlo simulated results reveal that the turbo coded cooperative OFDM system with MIMO antennas scheme incorporates coding gain, diversity gain and cooperation gain successfully over the direct transmission scheme under identical conditions.
Environmentally Concerned Logistics Operations in Fuzzy Environment: A Literature Survey
Authors: Tozanli Ozden , Duman Gazi , Kongar Elif , Gupta Surendra
Published: June 2017

Growing environmental awareness coupled with stricter governmental regulations has fueled the need for integrating sustainability into supply chain and logistics activities. Accordingly, recent studies in the literature have emphasized the significance of environmentally concerned logistics operations (ECLO). Research in the broad area of ECLO encompasses a wide range of topics including sustainable supply chain, green supply chain, closed-loop supply chain, low-carbon logistics, and waste management. In this paper, a comprehensive content analysis and area review is presented. Over 800 papers published between 1994 and 2017 in peer-reviewed journals, proceedings, and book chapters are utilized. These papers are analyzed in consecutive stages after being reviewed under a structural dimension process that addresses the fields of environmentally concerned logistics operations. Following the state-of-the-art review, a detailed analysis of ECLO research with a special emphasis on fuzzy applications is provided. The findings clearly indicate that the fuzzy multi-criteria decision making technique is a frequently used hybrid method, whereas fuzzy sets theory and other fuzzy hybrid techniques identify a gap in the related literature. This paper provides further critical analysis and other research suggestions in order to clarify these gaps and offer additional research perspectives. This information may provide extensive data that will enable future researchers to fill these gaps within this field.
Synthesis of Au NP@MoS2 Quantum Dots Core@Shell Nanocomposites for SERS Bio-Analysis and Label-Free Bio-Imaging
Authors: Fei Xixi , Liu Zhiming , Hou Yuqing , Li Yi , Yang Guangcun , Su Chengkang , Wang Zhen , Zhong Huiqing , Zhuang Zhengfei , Guo Zhouyi
Published: June 2017

In this work, we report a facile method using MoS2 quantum dots (QDs) as reducers to directly react with HAuCl4 for the synthesis of Au nanoparticle@MoS2 quantum dots (Au NP@MoS2 QDs) core@shell nanocomposites with an ultrathin shell of ca. 1 nm. The prepared Au NP@MoS2 QDs reveal high surface enhanced Raman scattering (SERS) performance regarding sensitivity as well as the satisfactory SERS reproducibility and stability. The limit of detection of the hybrids for crystal violet can reach 0.5 nM with a reasonable linear response range from 0.5 μM to 0.5 nM (R2 ≈ 0.974). Furthermore, the near-infrared SERS detection based on Au NP@MoS2 QDs in living cells is achieved with distinct Raman signals which are clearly assigned to the various cellular components. Meanwhile, the distinguishable SERS images are acquired from the 4T1 cells with the incubation of Au NP@MoS2 QDs. Consequently, the straightforward strategy of using Au NP@MoS2 QDs exhibits great potential as a superior SERS substrate for chemical and biological detection as well as bio-imaging.
“When the Bug Cannot Be Killed”—The Rising Challenge of Antimicrobial Resistance
Authors: Ofori-Asenso Richard
Published: June 2017

Antimicrobial resistance is a major global health issue that has the potential to reverse the substantial progress made against infectious diseases over the past several decades. We need strategic measures to deal with this challenge, including an intensification of public funding for research into anti-microbial agents and their alternatives, stricter mechanisms to minimize antimicrobial misuse within both clinical and non-clinical settings, and support for the development of country-level initiatives. Only with sustained, concerted, and coordinated global efforts are we likely to overcome the current and future challenges posed by these emerging “superbugs”.
Thin Film Nanocomposite Membrane Filled with Metal-Organic Frameworks UiO-66 and MIL-125 Nanoparticles for Water Desalination
Authors: Kadhom Mohammed , Hu Weiming , Deng Baolin
Published: June 2017

Knowing that the world is facing a shortage of fresh water, desalination, in its different forms including reverse osmosis, represents a practical approach to produce potable water from a saline source. In this report, two kinds of Metal-Organic Frameworks (MOFs) nanoparticles (NPs), UiO-66 (~100 nm) and MIL-125 (~100 nm), were embedded separately into thin-film composite membranes in different weight ratios, 0%, 0.05%, 0.1%, 0.15%, 0.2%, and 0.3%. The membranes were synthesized by the interfacial polymerization (IP) of m-phenylenediamine (MPD) in aqueous solution and trimesoyl chloride (TMC) in an organic phase. The as-prepared membranes were characterized by scanning electron microscopy (SEM), transmission electron microscopy (TEM), contact angle measurement, attenuated total reflection Fourier transform infrared (ATR FT-IR) spectroscopy, and salt rejection and water flux assessments. Results showed that both UiO-66 and MIL-125 could improve the membranes’ performance and the impacts depended on the NPs loading. At the optimum NPs loadings, 0.15% for UiO-66 and 0.3% for MIL-125, the water flux increased from 62.5 L/m2 h to 74.9 and 85.0 L/m2 h, respectively. NaCl rejection was not significantly affected (UiO-66) or slightly improved (MIL-125) by embedding these NPs, always at >98.5% as tested at 2000 ppm salt concentration and 300 psi transmembrane pressure. The results from this study demonstrate that it is promising to apply MOFs NPs to enhance the TFC membrane performance for desalination.
Multiphysics Simulation and Experimental Investigation of Aluminum Wettability on a Titanium Substrate for Laser Welding-Brazing Process
Authors: Dal Morgan , Peyre Patrice
Published: June 2017

The control of metal wettability is a key-factor in the field of brazing or welding-brazing. The present paper deals with the numerical simulation of the whole phenomena occurring during the assembly of dissimilar alloys. The study is realized in the frame of potential applications for the aircraft industry, considering the case of the welding-brazing of aluminum Al5754 and quasi-pure titanium Ti40. The assembly configuration, presented here, is a simplification of the real experiment. We have reduced the three-dimensional overlap configuration to a bi-dimensional case. In the present case, an aluminum cylinder is fused onto a titanium substrate. The main physical phenomena which are considered here are: the heat transfers, the fluid flows with free boundaries and the mass transfer in terms of chemical species diffusion. The numerical problem is implemented with the commercial software Comsol Multiphysics™, by coupling heat equation, Navier-Stokes and continuity equations and the free boundary motion. The latter is treated with the Arbitrary Lagrangian Eulerian method, with a particular focus on the contact angle implementation. The comparison between numerical and experimental results shows a very satisfactory agreement in terms of droplet shape, thermal field and intermetallic layer thickness. The model validates our numerical approach.
Effect of the Temperature in the Mechanical Properties of Austenite, Ferrite and Sigma Phases of Duplex Stainless Steels Using Hardness, Microhardness and Nanoindentation Techniques
Authors: Argandoña Gorka , Palacio José , Berlanga Carlos , Biezma María , Rivero Pedro , Peña Julio , Rodriguez Rafael
Published: June 2017

The aim of this work is to study the hardness of the ferrite, austenite and sigma phases of a UNS S32760 superduplex stainless steel submitted to different thermal treatments, thus leading to different percentages of the mentioned phases. A comparative study has been performed in order to evaluate the resulting mechanical properties of these phases by using hardness, microhardness and nanoindentation techniques. In addition, optical microscopy, scanning electron microscopy (SEM) and X-ray diffraction (XRD) have been also used to identify their presence and distribution. Finally, the experimental results have shown that the resulting hardness values were increased as a function of a longer heat treatment duration which it is associated to the formation of a higher percentage of the sigma phase. However, nanoindentation hardness measurements of this sigma phase showed lower values than expected, being a combination of two main factors, namely the complexity of the sigma phase structure as well as the surface finish (roughness).
TiO2 Nanotubes on Ti Dental Implant. Part 2: EIS Characterization in Hank’s Solution
Authors: Monetta Tullio , Acquesta Annalisa , Carangelo Anna , Bellucci Francesco
Published: June 2017

Titania nanotubes are widely studied for their potential applications in several fields. In this paper, the electrochemical characterization of a dental implant, made of commercially pure titanium grade 2, covered by titania nanotubes, when immersed in Hank’s solution, is proposed. Few papers were found in the scientific literature regarding this topic, so a brief review is reported, concerning the use of some equivalent circuits to model experimental data. The analysis of results, obtained by using Electrochemical Impedance Spectroscopy, showed that: (i) a good correlation exists between the variation of Ecorr and the estimated values of the charge transfer resistance for both the bare- and the nanotube-covered samples, (ii) the nanostructured surface seems to possess a more active behaviour, while the effect could be over-estimated due to the real extent of the surface covered by nanotubes, (iii) the analysis of the “n” parameter, used to fit the experimental data, confirms the complex nature of nanostructured layer as well as that the nanotubes are partially filled by compounds containing Ca, P and Mg, when immersed in Hank’s solution. The results obtained in this work give a better understanding of the electrochemical behaviour of the nanotubes layer when immersed in Hank’s solution and could help to design a surface able to improve the implant osseointegration.
The Hydrothermal Fluid Evolution of Vein Sets at the Pipeline Gold Mine, Nevada
Authors: Blamey Nigel , Campbell Andrew , Heizler Matt
Published: June 2017

The origin of sediment-hosted Nevada gold deposits has been highly debated, especially regarding the relative contribution of multiple mineralizing events, particularly relating to the Cretaceous. We examined the Pipeline gold mine in north-central Nevada, focusing on data from the four vein sets in this atypical deposit where there is evidence for Cretaceous gold mineralization. Only the third, a quartz-sericite-pyrite-calcite vein set, has any link with the alteration styles and gold mineralization within the Pipeline deposit. Our geochemical results from fluid inclusion microthermometry and gas analysis show that the fluids from which quartz deposited were sourced from condensing magmatic volatiles and were trapped at ~300 °C and 2 kbar lithostatic pressure (~8 km). 40Ar/39Ar dating of sericite demonstrates that the quartz-sericite-pyrite veins formed at ~92 Ma, matching the dates of gold-associated epigenetic illite. Ore fluids enriched in CO2 and H2S caused decarbonation thereby releasing Fe2+ that reacted with H2S to form pyrite. Decreasing H2S destabilized gold bisulfide complexes and deposited gold. We conclude that this process can occur in a single Cretaceous event in advance of potential Tertiary mineralization.
Bioactive Mushroom Polysaccharides: A Review on Monosaccharide Composition, Biosynthesis and Regulation
Authors: Wang Qiong , Wang Feng , Xu Zhenghong , Ding Zhongyang
Published: June 2017

Mushrooms are widely distributed around the world and are heavily consumed because of their nutritional value and medicinal properties. Polysaccharides (PSs) are an important component of mushrooms, a major factor in their bioactive properties, and have been intensively studied during the past two decades. Monosaccharide composition/combinations are important determinants of PS bioactivities. This review summarizes: (i) monosaccharide composition/combinations in various mushroom PSs, and their relationships with PS bioactivities; (ii) possible biosynthetic pathways of mushroom PSs and effects of key enzymes on monosaccharide composition; (iii) regulation strategies in PS biosynthesis, and prospects for controllable biosynthesis of PSs with enhanced bioactivities.
Synthesis and Bioactivity Evaluation of N-Arylsulfonylindole Analogs Bearing a Rhodanine Moiety as Antibacterial Agents
Authors: Song Ming-Xia , Li Song-Hui , Peng Jiao-Yang , Guo Ting-Ting , Xu Wen-Hui , Xiong Shao-Feng , Deng Xian-Qing
Published: June 2017

Due to the rapidly growing bacterial resistance to antibiotics and the scarcity of novel agents under development, bacterial infections are still a pressing global problem, making new types of antibacterial agents, which are effective both alone and in combination with traditional antibiotics, urgently needed. In this paper, seven series of N-arylsulfonylindole analogs 5–11 bearing rhodanine moieties were synthesized, characterized, and evaluated for antibacterial activity. According to the in vitro antimicrobial results, half of the synthesized compounds showed potent inhibition against four Gram-positive bacteria, with MIC values in the range of 0.5–8 µg/mL. For multidrug-resistant strains, compounds 6a and 6c were the most potent, with MIC values of 0.5 µg/mL, having comparable activity to gatifloxacin, moxiflocaxin and norfloxacin and being 128-fold more potent than oxacillin (MIC = 64 µg/mL) and 64-fold more active than penicillin (MIC = 32 µg/mL) against Staphylococcus aureus ATCC 43300.
A Simple Defined Medium for the Production of True Diketopiperazines in Xylella fastidiosa and Their Identification by Ultra-Fast Liquid Chromatography-Electrospray Ionization Ion Trap Mass Spectrometry
Authors: Silva Michelli Massaroli da , Andrade Moacir dos Santos , Bauermeister Anelize , Merfa Marcus Vinícius , Forim Moacir Rossi , Fernandes João Batista , Vieira Paulo Cezar , Silva Maria Fátima das Graças Fernandes da , Lopes Norberto Peporine , Machado Marcos Antônio , Souza Alessandra Alves de
Published: June 2017

Diketopiperazines can be generated by non-enzymatic cyclization of linear dipeptides at extreme temperature or pH, and the complex medium used to culture bacteria and fungi including phytone peptone and trypticase peptone, can also produce cyclic peptides by heat sterilization. As a result, it is not always clear if many diketopiperazines reported in the literature are artifacts formed by the different complex media used in microorganism growth. An ideal method for analysis of these compounds should identify whether they are either synthesized de novo from the products of primary metabolism and deliver true diketopiperazines. A simple defined medium (X. fastidiosa medium or XFM) containing a single carbon source and no preformed amino acids has emerged as a method with a particularly high potential for the grown of X. fastidiosa and to produce genuine natural products. In this work, we identified a range of diketopiperazines from X. fastidiosa 9a5c growth in XFM, using Ultra-Fast Liquid Chromatography coupled with mass spectrometry. Diketopiperazines are reported for the first time from X. fastidiosa, which is responsible for citrus variegated chlorosis. We also report here fatty acids from X. fastidiosa, which were not biologically active as diffusible signals, and the role of diketopiperazines in signal transduction still remains unknown.
Five Unprecedented Secondary Metabolites from the Spider Parasitic Fungus Akanthomyces novoguineensis
Authors: Helaly Soleiman E. , Kuephadungphan Wilawan , Phongpaichit Souwalak , Luangsa-ard Janet Jennifer , Rukachaisirikul Vatcharin , Stadler Marc
Published: June 2017

Five new compounds including the glycosylated β-naphthol (1, akanthol), a glycosylated pyrazine (2, akanthozine), and three amide derivatives including a hydroxamic acid derivative (3–5) were isolated from the spider-associated fungus Akanthomyces novoguineensis (Cordycipitaceae, Ascomycota). Their structures were elucidated by using high resolution mass spectrometry (HRMS) and NMR spectroscopy. In this study, the antimicrobial, cytotoxic, anti-biofilm, and nematicidal activities of the new compounds were evaluated. The distribution pattern of secondary metabolites in the species was also revealed in which more isolates of A. novoguineensis were encountered and their secondary metabolite profiles were examined using analytical HPLC with diode array and mass spectrometric detection (HPLC-DAD/MS). Remarkably, all isolated compounds are specifically produced by A. novoguineensis.
Microgroove and Collagen-poly(ε-caprolactone) Nanofiber Mesh Coating Improves the Mechanical Stability and Osseointegration of Titanium Implants
Authors: Khandaker Morshed , Riahinezhad Shahram , Williams Wendy , Wolf Roman
Published: June 2017

The effect of depositing a collagen (CG)-poly-ε-caprolactone (PCL) nanofiber mesh (NFM) at the microgrooves of titanium (Ti) on the mechanical stability and osseointegration of the implant with bone was investigated using a rabbit model. Three groups of Ti samples were produced: control Ti samples where there were no microgrooves or CG-PCL NFM, groove Ti samples where microgrooves were machined on the circumference of Ti, and groove-NFM Ti samples where CG-PCL NFM was deposited on the machined microgrooves. Each group of Ti samples was implanted in the rabbit femurs for eight weeks. The mechanical stability of the Ti/bone samples were quantified by shear strength from a pullout tension test. Implant osseointegration was evaluated by a histomorphometric analysis of the percentage of bone and connective tissue contact with the implant surface. The bone density around the Ti was measured by micro–computed tomography (μCT) analysis. This study found that the shear strength of groove-NFM Ti/bone samples was significantly higher compared to control and groove Ti/bone samples (p < 0.05) and NFM coating influenced the bone density around Ti samples. In vivo histomorphometric analyses show that bone growth into the Ti surface increased by filling the microgrooves with CG-PCL NFM. The study concludes that a microgroove assisted CG-PCL NFM coating may benefit orthopedic implants.
The Non-Coding RNA Journal Club: Highlights on Recent Papers—5
Authors: Achour Cyrinne , Bogard Baptiste , Hubé Florent , Mani Sendurai A. , Santulli Gaetano , Taube Joseph H.
Published: June 2017

We are delighted to share with you our fifth Journal Club and highlight some of the most interesting papers published recently.[...]
Adherence to a Vegetarian Diet and Diabetes Risk: A Systematic Review and Meta-Analysis of Observational Studies
Authors: Lee Yujin , Park Kyong
Published: June 2017

We quantitatively assessed the association between a vegetarian diet and diabetes risk using pooled estimates from observational studies. Electronic database searches for articles published from January 1980 to May 2016 were independently performed by two investigators, and 13 articles (14 studies) were identified. The pooled odds ratio (OR) for diabetes in vegetarians vs. non-vegetarians was 0.726 (95% confidence interval (CI): 0.608, 0.867). In the subgroup analyses, this inverse association was stronger for the studies conducted in the Western Pacific region (OR 0.514, 95% CI: 0.304, 0.871) and Europe/North America (OR 0.756, 95% CI: 0.589, 0.971) than studies conducted in Southeast Asia (OR 0.888, 95% CI: 0.718, 1.099). No study had a substantial effect on the pooled effect size in the influence analysis, and the Egger’s (p = 0.465) and Begg’s tests (p = 0.584) revealed no publication bias. This meta-analysis indicates that a vegetarian diet is inversely associated with diabetes risk. Our results support the need for further investigations into the effects of the motivations for vegetarianism, the duration of the adherence to a vegetarian diet, and type of vegetarian on diabetes risk.
“Political Correctness” from a “Border Reason”: Between Dignity and the Shadow of Exclusion
Authors: Cepeda-Mayorga Ivón
Published: June 2017

The concept of political correctness highlights a set of principles and structures that should (or, in other cases, must) be followed to pursue a specific social behavior that characterizes a society and endorses an ideal identity. Nevertheless, even when this behavior implies a sense of social recognition and acceptance by a specific group, it also encompasses a risk of imposing a particular model of life, halting the emergence of criticisms and differences as far as it could be misguided to promote discrimination and exclusion. All of these raise the question of whether it is possible to conceive political correctness from a perspective of inclusion that transcends this layer of exclusion. If this is the case, following Eugenio Trías’ philosophy about the limit, the concept needs to be reconsidered through a “border reason” that enables one to conceive the benefits it brings as well as the criticisms that come from the analysis of the “shadowy” practice of the concept. This approach will lead to accepting that political correctness fulfills a function for society but that it requires a reflexive attitude along with its practices as part of a border relation between its benefits and the risks that it also has to tackle. Finally, a concept that could serve as a hinge to reinforce the perspective of a border limit is dignity, which could lead to an ethical reflection that underpins politically correct actions.
Influence of the Processing Parameters on the Fiber-Matrix-Interphase in Short Glass Fiber-Reinforced Thermoplastics
Authors: Sambale Anna , Schöneich Marc , Stommel Markus
Published: June 2017

The interphase in short fiber thermoplastic composites is defined as a three-dimensional, several hundred nanometers-wide boundary region at the interface of fibers and the polymer matrix, exhibiting altered mechanical properties. This region is of key importance in the context of fiber-matrix adhesion and the associated mechanical strength of the composite material. An interphase formation is caused by morphological, as well as thermomechanical processes during cooling of the plastic melt close to the glass fibers. In this study, significant injection molding processing parameters are varied in order to investigate the influence on the formation of an interphase and the resulting mechanical properties of the composite. The geometry of the interphase is determined using nano-tribological techniques. In addition, the influence of the glass fiber sizing on the geometry of the interphase is examined. Tensile tests are used in order to determine the resulting mechanical properties of the produced short fiber composites. It is shown that the interphase width depends on the processing conditions and can be linked to the mechanical properties of the short fiber composite.