bluuebunny/crossref_metadata_2025 huggingface dataset:
The Mediating Role of Sexual Satisfaction and Anger in the Relationship Between Partner-Related Obsessive Compulsive Symptoms and Sexual Self-Schema
Authors: Güler Kahraman
Published: September 2024

Aim: The study was conducted to examine the relationship between partner-related obsessive-compulsive symptoms and sexual self-schemas and to determine the indirect effect of sexual satisfaction and anger on this relationship.
Method: The research was conducted with 510 volunteer participants aged 18-50. The participants participated on a voluntary basis and the sample was reached randomly. Personal Information Form, Sexual Self-Schema Scale, The Trait Anger Expression Scale, New Sexual Satisfaction Scale and Partner-Related Obsessive-Compulsive Symptom Scale were used to collect the data. Statistical analyses were performed using SPSS 27 software.
Results: The findings of the study revealed that there was a significant negative relationship between obsessive-compulsive symptoms related to the partner and sexual satisfaction and sexual self-schemas, and a significant positive relationship with anger. A positive relationship was found between sexual self-schemas and sexual satisfaction. A significant negative relationship was found between anger and sexual satisfaction and sexual self-schemas.
Conclusion: As a result of the study, it was found that there was a significant negative relationship between individuals' having obsessive-compulsive symptoms and their sexual self-schemas, and that anger and sexual satisfaction had a significant indirect effect on this relationship.
Vivaldi or Not Vivaldi? The Unreliable Attribution of the Sonata RV 34
Authors: Talbot Michael
Published: September 2024

Ever since Johann Georg Pisendel copied, and took back to Dresden in 1717, the solo sonata in B flat for violin (or perhaps oboe) attributed by him to Antonio Vivaldi, the authorship of this work has been uncontested. Designated RV 34 in the standard Vivaldi catalogue, it is a popular piece among performers. But there are persuasive external and internal features establishing almost beyond doubt that its true author was the Venetian amateur composer Diogenio Bigaglia (1678–1745). Pisendel’s incorrect attribution may have been an error inherited from a non-autograph source. The article takes the opportunity to add details about Bigaglia’s life and describe his musical style.
Perceptions and Behaviors of Nurses and Physicians During Bedside Rounds in Medical-Surgical Units
Authors: Natarajan Aishwarya , Venegas Manuel G. , Mai Dylan , Dowling Erin , Simon Wendy , Pessegueiro Antonio M. , Vangala Sitaram , Dermenchyan Anna
Published: September 2024

Background

Communication and collaboration among health care professionals during bedside rounds improve patient outcomes and nurses’ and physicians’ satisfaction.

Objectives

To determine barriers to nurse-physician communication during bedside rounds and identify opportunities to improve nurse-physician collaboration at an academic medical center.

Methods

A survey with Likert-scale and open-ended questions regarding professional attitudes toward nurse-physician communication was administered to 220 nurses and physicians in medical-surgical units to assess perceptions of participation in bedside rounds. After the survey was given, observational data from 1007 bedside rounds were collected via a standardized data collection tool.

Results

Nurses and physicians perceived different barriers to including nurses in bedside rounds. Nurses most often cited being unaware that bedside rounds were occurring (38 of 46 nurses [83%]); physicians most often cited nurse unavailability (43 of 52 physicians [83%]). Of 1007 observed rounds, 602 (60%) involved in-person contact of nurses and physicians; 418 (69%) of the 602 included a conversation between the nurse and physician about the nurse’s concerns. Of 355 rounds with no in-person or telephone contact between nurses and physicians, the medicine team did not contact the nurse in 284 (80%). Conversations about nurses’ concerns occurred more often after physician-initiated contacts (73% of 369 contacts) and nurse-initiated contacts (74% of 93 contacts) than after chance encounters (57% of 140 contacts).

Conclusion

Initiating discussions of care between nurses and physicians and discussing nurses’ concerns during bedside rounds have multiple benefits.
Explainable Artificial Intelligence for Early Prediction of Pressure Injury Risk
Authors: Alderden Jenny , Johnny Jace , Brooks Katie R. , Wilson Andrew , Yap Tracey L. , Zhao Yunchuan (Lucy) , van der Laan Mark , Kennerly Susan
Published: September 2024

Background

Hospital-acquired pressure injuries (HAPIs) have a major impact on patient outcomes in intensive care units (ICUs). Effective prevention relies on early and accurate risk assessment. Traditional risk-assessment tools, such as the Braden Scale, often fail to capture ICU-specific factors, limiting their predictive accuracy. Although artificial intelligence models offer improved accuracy, their “black box” nature poses a barrier to clinical adoption.

Objective

To develop an artificial intelligence–based HAPI risk-assessment model enhanced with an explainable artificial intelligence dashboard to improve interpretability at both the global and individual patient levels.

Methods

An explainable artificial intelligence approach was used to analyze ICU patient data from the Medical Information Mart for Intensive Care. Predictor variables were restricted to the first 48 hours after ICU admission. Various machine-learning algorithms were evaluated, culminating in an ensemble “super learner” model. The model’s performance was quantified using the area under the receiver operating characteristic curve through 5-fold cross-validation. An explainer dashboard was developed (using synthetic data for patient privacy), featuring interactive visualizations for in-depth model interpretation at the global and local levels.

Results

The final sample comprised 28395 patients with a 4.9% incidence of HAPIs. The ensemble super learner model performed well (area under curve = 0.80). The explainer dashboard provided global and patient-level interactive visualizations of model predictions, showing each variable’s influence on the risk-assessment outcome.

Conclusion

The model and its dashboard provide clinicians with a transparent, interpretable artificial intelligence– based risk-assessment system for HAPIs that may enable more effective and timely preventive interventions.
Biochanin-A attenuates high-fat diet and streptozotocin-induced hyperlipidemia and oxidative stress in rats by improving antioxidant status and lipid metabolic markers
Authors: Sethumathi P. P. , Uddandrao V. V. Sathibabu , Chandrasekaran P. , Sengottuvelu S. , Tamilmani P. , Ponmurugan P. , Vadivukkarasi S. , Santhanakumar M. , Begum M. Shabana , Saravanan G.
Published: September 2024

Objective:

To determine how biochanin-A (BCA) affects high-fat diet and streptozotocin-induced pathological changes in lipid metabolism and antioxidant status in diabetic rats.

Methods:

Diabetic rats were orally administered BCA (10 mg/kg body weight) for 30 days to investigate its effects on lipid profiles and oxidative stress markers in the liver and kidney. In addition, the mRNA expression of antioxidant and lipid metabolism enzymes in the liver was examined.

Results:

BCA attenuated hyperlipidemia by regulating mRNA expressions of HMG-CoA reductase, fatty acid synthase, carnitine palmitoyl transferase, and acetyl-CoA carboxylase. Additionally, BCA reduced high-fat diet and streptozotocin-induced oxidative stress by suppressing lipid peroxidation, improving superoxide dismutase, catalase, and glutathione peroxidase levels, and upregulating mRNA expressions of these enzymes.

Conclusions:

BCA may be a promising nutraceutical for the treatment of dyslipidemia and oxidative stress associated with diabetes.
Ocimum sanctum extract preserves neuronal echotexture and controls seizure in lithium-pilocarpine induced status epilepticus rats
Authors: Pattnaik Soumya Sucharita , Sarangi Sudhir Chandra , Sharma Deeksha , Sinha Surabhi , Nag Tapas C , Nambirajan Aruna , Tripathi Manjari
Published: September 2024

Objective:

To investigate the effect of Ocimum sanctum hydroalcoholic extract (OSHE) on seizure control and neuronal injury in rats with lithium-pilocarpine-induced status epilepticus (SE).

Methods:

SE was induced by administering lithium chloride followed by pilocarpine 24 h later. OSHE was administered either alone or in combination with valproate (VPA) 3 days before SE induction until 14 days post-SE induction. Seizure parameters were recorded on day 1 (0-3 h), day 1-3 and day 4-14 post-SE. On day 14 post-SE, neurobehavioural tests (elevated plus maze and passive avoidance) were done followed by total antioxidant capacity, neuron-specific enolase, immunohistochemistry, and electron microscopic assessment in the hippocampus and cortex tissue.

Results:

OSHE+VPA provided more significant seizure protection (75%) than VPA (62.5%), OSHE (62.5%), or SE control (12.5%) (overall P=0.003). The latency to stage-3/4 seizures was increased and the number of stage-3/4 seizures was reduced in all treatment groups compared to the SE control group (P=0.002 and <0.001, respectively). The OSHE+VPA group also had better memory retention than other treatment groups (P<0.001) in the passive avoidance test. Total antioxidant capacity level was significantly higher and neuron-specific enolase was lower in the OSHE and OSHE+VPA groups compared to the SE control group. Electron microscopic study showed significant myelin sheath damage (67.5%, P<0.05) and axonal degeneration (51.8%, P<0.001) in the hippocampus of the SE control group, which were alleviated by OSHE or OSHE+VPA treatment. In immunohistochemical analysis, the OSHE, OSHE+VPA, and VPA groups had a significantly higher number of viable neurons and less neuronal loss compared to the SE control in the hippocampus (P<0.001).

Conclusions:

OSHE either alone or in combination with VPA shows better seizure control by preservation of neuronal echotexture and reducing oxidative stress in the hippocampus.
When Impedance Trend Lies, Remote Monitoring Helps for Diagnosis
Authors: Scicchitano Marco , Schirripa Valentina , Loricchio Maria Luisa , Castro Antonio , Iulianella Renzo Venanzio , Perna Silvia , Centurion Carlos Aznaran , Albano Bruno , Rizzo Veronica , Granatelli Antonino
Published: September 2024

We described the fracture of an ICD lead in a patient at the third device replacement.Through the remote monitoring electric interference was detected on the defibrillator lead despite the pacing and shock impedances during the leadlifetime remained stable and in a normal range. X-ray confirmed the lead failure and patient underwent to a lead replacement.
Assessment of the Mental and Physical Health Problems of Clients Undergoing Opioid Substitution Therapy: A Hospital-based Cross-sectional Study
Authors: Rathi Priyanka , Joseph Jaison , Devi Rajeshwari , Arya Siddharth
Published: September 2024

Background:

Opioid substitution therapy (OST) is one of the most effective treatment options for opioid dependence. However, there are not enough credible studies available on the health-care problems of clients undergoing OST.

Materials and Methods:

The study recruited 100 patients undergoing OST on an outpatient basis using a consecutive sampling technique. The mental and physical health problems were evaluated using the Patient Health Questionnaire-9, General Anxiety Disorder Scale 7, and a self-reported physical symptom checklist.

Results:

The estimates of depression and anxiety were 52% and 39%, respectively. The general physical ailments were more often reported by the subjects followed by musculoskeletal problems and neurological problems. A significant correlation was observed between physical health problems with anxiety (r = 0.40, P < 0.01) and depression (r = 0.37, P < 0.01).

Conclusion:

The clients undergoing OST have a high degree of self-reported health problems and psychological distress in this setting.
Profile of Elderly Substance Users-seeking Treatment: A Retrospective Analysis from a Tertiary Care Center in North India
Authors: Rathee Sunila , Joseph Jaison , Kumar Vinay , Arya Sidharth , Taneja Kajal , Gupta Rajiv
Published: September 2024

Introduction:

The substance use among the elderly is a growing enormity and an accurate understanding of the patterns of substances of the elderly is missing in the literature. Therefore, this study explored the sociodemographic and clinical profile of the elderly population-seeking treatment at a tertiary care center in North India.

Methods:

The present study reviewed the case notes of the elderly registered in the de-addiction center of North India. The cohort for this study consisted of all outpatients aged more than 60 years registered in the study setting from January 2017 to December 2021. The profile of the study subjects including sociodemographic and clinical data was reviewed based on the existing structured pro forma used in the department.

Results:

The data for a total of 508 treatment-seeking elderly aged more than 60 years were analyzed in which the mean age at the presentation was 65 ± 3.8 years. We identified that tobacco (57.5%), alcohol (52.6%), and opioids (36.2%) were the leading substances used in this setting. We noted a statistically significant association among the study subjects with alcohol, opioid, and tobacco dependence based on the presence or absence of a co-occurring medical illness.

Conclusion:

The present retrospective chart review identified that tobacco, alcohol, and opioids were the leading substances used among treatment-seeking elderly in this setting. Estimating the magnitude of substance use among the elderly is crucial to predict the imposed burden of the illness and ascertain the treatment and prevention strategies for controlling the magnitude of the problem.
Roadblocks for Successful Treatment in Opioid Substitution Therapy Center in India: An Opinion based on Observation
Authors: Mishra Sudha
Published: September 2024

In India, opioid addiction is a serious emerging problem. Opioid substitution therapy (OST), particularly buprenorphine, has been shown to be very cost-effective and has significant evidence of reduced drug-related HIV risk behaviors, crime, and illegal opioid usage. Raising the standard of living and enhancing public health is one of the main goals of this therapy, with a special emphasis on the center’s efforts to promote harm reduction. However, incidents of reported patient abuse or misuse of these drugs frequently lead to unfavourable opinions of this crucial life-saving procedure. Therefore, the administration and government must move immediately to address the issue.
Efficacy and Clinical Predictors of Response to Repetitive Transcranial Magnetic Stimulation Treatment in Resistant Obsessive-compulsive Disorder
Authors: Mohanty Prabhojit , Gadgile Pawan , Tomar Shweta , Pradhan Sunay
Published: September 2024

Deep transcranial magnetic stimulation has been effectively used as a therapy for refractory obsessive compulsive disorder (OCD). Number of sessions approved by FDA is 20. Here, we report the case of 59 year old female with treatment refractory obsessive compulsive disorder (OCD) whose symptoms markedly improved only after 10 sessions of deep TMS over Dorso Medial Prefrontal Cortex. Our case report shows that, even with fewer sessions than indicated, significant symptoms remission can be achieved with deeper penetration of magnetic field with marked reduction in distress of patient and significant improvement in socio-occupational domain. Her Y-BOCS score reduced by 66% at the end of 10 completed sessions.
Association of Personality Traits of Alcohol-dependent Patients with Their Psychiatric Comorbidities: A Cross-sectional Study from Central Rural India
Authors: Gedam Sachin Ratan , Patil P S , Najan Ashok , Jain Pankaj , Babar Vijay
Published: September 2024

Introduction:

Alcohol dependence syndrome (ADS) is a significant health problem all over the world. Alcohol-dependent individuals have a high prevalence of psychiatric comorbidities and nonadaptive personality traits that may influence the pathogenesis, treatment outcome, clinical course, and relapse of ADS.

Aim:

The aim of this study was to assess the personality traits and psychiatric comorbidities of alcohol-dependent patients and to determine the association of personality traits with psychiatric comorbidities in ADS.

Methodology:

An observational study was conducted on 100 patients of ADS from Acharya Vinoba Bhave Rural Hospital, Sawangi Wardha, Maharashtra. They were assessed through semi-structured sociodemographic pro forma, Mini-International Neuropsychiatric Interview PLUS, and 16 Personality Factor Inventory.

Results:

Most of the patients scored high on personality traits such as dominance (67%), warmth (56%), sensitivity (70%), social boldness (56%), openness to change (65%), vigilance (77%), and perfectionism (52%) while they scored low on factors privateness (50%) and liveliness (35%). The prevalence of psychiatric comorbidity was found to be 49%, with mood disorders (21%) being the most common diagnosis. Personality factors dominance (0.0001) and social boldness (0.042) were significantly associated with psychiatric comorbidities with P < 0.05.

Conclusion:

The personality traits and psychiatric comorbidity need to be addressed at the time of management to improve outcome.
Obsessive–compulsive Disorder in a Young Girl with Subependymal Heterotopia, Aqueductal Stenosis, and Mega Cisterna Magna Along with Left-sided Mild Cerebellar Hypoplasia
Authors: Pal Sourabh Naresh , Kadam Kranti S.
Published: September 2024

Gray matter heterotopia (GMH) is a rare disorder in the general population, but recent attention to its psychiatric aspects encouraged us to introduce a patient with a form of gray matter heterotopia, who suffers from the anatomical abnormalities with a variety of psychiatric disorders. During the late teenage years or early adulthood, a wide variety of neuropsychiatric symptoms may be present, which can lead to diagnostic difficulties. The Dandy–Walker variant is a milder form of the Dandy–Walker complex and is characterized by normal-sized posterior fossa, mild vermian hypoplasia, and a cystic lesion that communicates with the fourth ventricle. This syndrome has been described in association with schizophrenia, obsessive–compulsive disorder (OCD), manic episode, psychosis, and recurrent catatonia. Presenting a case report of an 11-year-old girl with OCD who was accidentally detected with the presence of GMH along with aqueductal stenosis, mega cisterna magna, and left-sided mild cerebellar hypoplasia.
The Role of Spiritual Well-Being and Religious Coping in Psychiatric Morbidities Associated with Breast Cancer Patients: A Cross-Sectional Analysis
Authors: Shelke Swati Balkrishna , Kedare Jahnavi S. , Sinha Deoraj
Published: September 2024

Background:

Spirituality and religious resources support and enhance both overall and emotional well-being during adversity such as diagnosis of breast cancer. Breast cancer patients are at higher risk of developing severe anxiety, depression, and potential mood disorders.

Aim:

The aim is to assess, compare, and correlate spiritual well-being and religious coping in patients with breast cancer with and without psychiatric disorders (anxiety and depression).

Materials and Methodology:

Recently diagnosed 90 treatment-naïve breast cancer patients were selected in adherence to the inclusion and exclusion criteria. Hospital Anxiety and Depression Scale (HADS), Spiritual Assessment Scale, and Brief Religious Coping Scale were applied to the sample population. The study population was divided into two groups depending on scores of HADS, those having psychiatric disorders, and those who did not have. The data were analyzed using Mann‒Whitney test and Pearson’s correlation coefficient in the SPSS version 21.

Results:

More than half (61.1%) of the females suffered from psychiatric disorders after diagnosis of breast cancer. About 50% and 38.9% of the study population developed significant emotional distress, leading to the diagnosis of cases of anxiety and depression, respectively. Females suffering from psychiatric disorders have significantly lower spirituality, positive religious coping, and significantly higher negative religious coping than females without any psychiatric disorder. Total spirituality score (P = 0.034) is making a significant contribution toward predicting depression. Negative religious coping is making a significant contribution toward predicting both anxiety (P = 0.008) and depression (P = 0.045).

Conclusion:

The study suggests that spirituality and religion-based coping facilitates adaptive psychological adjustment to cancer and decreases the prevalence of anxiety and depression.
Multidisciplinary, Interdisciplinary, and Transdisciplinary Approaches to Neurodevelopmental Disability Interventions: A Brief Overview
Authors: Kuruvilla Rone Mathew , Rajan Santhosh Kareepadath , Joseph Jasmine
Published: September 2024

Neurodevelopmental disabilities in children, affecting personal, social, academic, or occupational functioning, present a global challenge. Neurodevelopmental issues contribute significantly to learning disabilities, emphasizing the need for early intervention. The Rashtriya Bal Swasthya Karyakram (RBSK), a government program launched in 2013, is a multidisciplinary initiative addressing child health. This article compares three distinct approaches – multidisciplinary, interdisciplinary, and transdisciplinary – in the context of early intervention. Multidisciplinarity utilizes knowledge from various disciplines, while interdisciplinarity synthesizes links between disciplines, and transdisciplinarity integrates sciences beyond traditional boundaries. Challenges in early intervention, particularly with RBSK, include limited awareness and accessibility, necessitating ongoing efforts and innovations. This study concludes by emphasizing the transformative potential of embracing innovative solutions to create a more inclusive and equitable future for children with neurodevelopmental difficulties and their families.
Clinical Study to Evaluate the Anti-Plaque Effect of Neem Dantakashtha
Authors: Kumar Pankaj , Devi Durgawati , Bhatnagar Sharad
Published: September 2024

Introduction:

Dental plaque is the community of microorganisms found on a tooth surface as a biofilm, embedded in a matrix of polymers of host and bacterial origin. Progression and buildup of dental plaque can give rise to tooth decay – the localized destruction of the tissues of the tooth by acid produced from the bacterial degradation of fermentable sugar – and periodontal problems such as gingivitis and periodontitis.

Aim:

The aim of this clinical study is to evaluate the anti-plaque effect of Neem (Azadirachta indica) Dantakastha.

Materials and Methods:

The present study was an open randomized controlled interventional study wherin 30 apparently health people were participated. Registered volunteers were divided equally into two groups: Group A and Group B. Group A – the control group did not receive any intervention. This group was on its daily dental hygiene routine practice. Group B – the test group was subjected to do two-time toothbrushing with Nimba plant twig for a duration of 1 month.

Results:

In this study, the plaque index of Silness and Loe was measured before and after the completion of the trial period both in the control and interventional group. There are not any significant changes in Group A (P = 0.5879). There are highly significant changes in intervention Group B (P < 0.0001).

Conclusion:

Hence, it is concluded that Neem Dantakastha has a good effect as an anti-plaque agent as compared to the control group.
Ayurvedic Add-on Therapy for β-Thalassemia Major Cases on Quality of Life
Authors: Mitra Achintya , Tripathi Arunabh , Ravte Rohit Kumar , Hazra Kalyan , V. Prasad P.V.
Published: September 2024

Blood transfusions which were suggested as treatment for beta thalassemia major cases brought down the quality of life by several means like splenomegaly, growth retardation, poor appetite, low hemoglobin (Hb), increased serum ferritin level, etc. In present study the group of 79 patients which were selected were having such symptoms arouse due to repeated conventional blood transfusion. the patient was given Amlavetas (Garcinia pedunculata Roxb. ex Buch. Ham) dry fruit pulp (5 g) once daily in the early morning on an empty stomach regularly for 6 months without imposing any restriction to their regular food and other medicines for his existing comorbidities. Objective parameters such as Hb (g%), body weight (Kg), loss of appetite serum ferritin (ng/dl), and frequency of blood transfusion were assessed which ultimately help to understand the QoL of the subjects. The Hb percentage after 3rd month and 6th month was 6.94 ± 1.57 g% and 6.99 ± 1.52 g% which were significant when compared with baseline values (6.42 ± 1.37 g%, P < 0.001). The serum ferritin was significantly increased (P < 0.005) in the follow up visits when compared with baseline value 3112.13 ± 2801.20 ng/dl. The gain in body weight, increase in appetite and reduced blood transfusion rate indicates the quality of life, revealed by the improvement of his blood parameters including the serum ferritin level. Amlavetas fruit pulps can be a potential iron chelating as well as erythropoiesis Ayurvedic intervention to normalize iron metabolism, relieve thalassemia symptoms, and increase BT intervals with better life expectancy.
Management of Vipadika (~Plantar Psoriasis) in Ayurvedic Prospect
Authors: Varsakiya Jitendrakumar Nathabhai , Goyal Mandip , Kathad Divyarani , Dhaniya Alisha , Kumari Ritu
Published: September 2024

Plantar psoriasis accounts for 3%–4% of all psoriasis cases and produces significant functional and social disability. Plantar psoriasis is a variant of psoriasis that characteristically affects the skin of the soles with features, i.e.,; hyperkeratotic, pustular, or mixed morphologies. Many of the skin disorders in Ayurveda have been described under the heading of Kushtha (group of skin diseases) and Kshudra Kustha. Vipadika (Plantar psoriasis) is one of the diseases which has been included under the heading of Kshudra Kushtha. In classics, clinical features of Vipadika are cracks (Sphutana) either in palms or soles or in both with pain. A 42-year-old male patient visited our outpatient department with complaints of scaling and fissure of skin of bilateral soles, with bleeding from cracks for 6–8 months. Examination and history lead to a diagnosis of Vipadika (Plantar psoriasis). This case was managed with Virechana Krama (~therapeutic purgation), followed by Shaman Chikitsa (pacifying therapy) with internal administration of Guduchi Churna 2 g twice a day after meal with luke warm water, Panchvalkal Kwath once 4 ml morning empty stomach, with Panchvalkal Kwath wash in sufficient quantity, Triphala Churna Avchurnan (topical dusting of powder) and local application of Jatyadi tail along with Pathya (wholesome regime), and Apathya (unwholesome regimen) for 4 months. The effect of the therapy was assessed by the signs and symptoms before and after the treatment. The treatment modalities showed relief in patient's signs and symptoms. Hence, Ayurveda procedures and medicaments are promising in the management of Vipadika (~Plantar psoriasis).
Blue Print of Ayurvedic Modalities to Prevent Risk Factors in Cancer
Authors: Aku Amulya Murthy , Patil Ashok
Published: September 2024

The cancerous process is the result of disturbed cell function. This is due to the accumulation of many genetic and epigenetic changes within the cell, expressed in the accumulation of chromosomal or molecular aberrations, which leads to genetic instability. Cancer is an uncontrolled growth disorder of cells characterized by the formation of tumor, invasiveness, metastasis, and anaplasia. Ayurveda describes a variety of clinical conditions which have approximate similarities with cancer. The disease is a major cause of motility and morbidity across the world. Despite a huge advancement in therapeutic strategies, it is still a major cause of death worldwide. Prevention of cancer is the need of the hour. To explore and understand the modifiable, nonmodifiable risk factors of cancer as well as to find out the various Ayurvedic preventive perspective, this review study has been undertaken. Ayurvedic classics, articles, books, and journals were gone through manually for relevant theories and principles related to risk factors of cancer and how they contribute to cancer. Ayurvedic modalities were also explored, which can help to prevent these risk factors. On exploring different literatures, it was found that mainly under modifiable risk factors-diet, lack of activity, stress, habits (e.g., smoking and alcohol), environmental factors, and unsafe sex with infected personals (human papillomavirus) contribute to cancer. While under nonmodifiable risk factors, family history was found to be a main contributory risk factor.
Concept of Genetic Disorders in Ayurveda and Their Prevention
Authors: Choudhury Bishnu , Varsakiya Jitendrakumar Nathabhai , Kumar Vijay , Mahesekar Neeta
Published: September 2024

The most basic prerequisite for any nation's affluence is healthy progeny. Congenital/hereditary disorders have a serious effect on a person's health. A study on genetic disorders exposes that 3%–5% of all births result in congenital deformities and 20%–30% of all infant deaths are due to genetic disorders. Even though science is advancing at a fast pace, there is still some lack of certainty about the underlying cause of these diseases, as well as their prevention and management. In Ayurveda, the concept of congenital diseases is comprehensively discussed by Sahaja Roga, Kulaja Roga, and Adibala Pravritta Roga, and Janmabala Pravrutta Roga. The antenatal causes, preventive measures, and types of diseases have been discussed explicitly. The importance of Shad-Garbhakara Bhavas (six pro-creative factors) such as Matrija (maternal), Pitrija (paternal), Atmaja (soul), Rasaja (nutritional), Satmyaja (wholesomeness), and Sattvaja (psyche/mind) for the creation of healthy progeny has been described in Ayurvedic texts. The conjunction of these pro-creative factors is considered necessary for healthy progeny. The physical, mental, social, and spiritual well-being of both the parents during pregnancy and the practice of a wholesome regimen play a significant role in ensuring a healthy offspring. Nonconsanguineous marriage, appropriate age of marriage, and conception are also described in Ayurvedic text as preventive for genetic disorders. Considering the seriousness of the issue and knowledge gap, we review to comprehensively encapsulate the concept, diversity, and preventive aspects of genetic disorders described in Ayurveda as well as its understanding in contemporary science.
A Comparative Study to Assess the Vajikarana Effect of Vrishya Pupalika and Modak (Aphrodisiac Food Preparations) Against Placebo
Authors: Ram Sukh , Devi Durgawati , Kumar Pankaj
Published: September 2024

Introduction:

Sexual health is essential for happy marital life and healthy conception. Vajikarana (aphrodisiac) can be used as preventive and curative method in the sexual health. Various food preparations mentioned under Vajikarana (aphrodisiac) therapy for healthy and diseased.

Materials and Methods:

The study has been designed as open randomized comparative trial with thirty healthy married males between 25 and 45 years of age which were randomly assigned into three groups, each with ten healthy volunteers. Group A or placebo Group was treated with Amalaki churna 500 mg orally in capsule form once a day with Anupana of Sharkara yukta Dugdha along with healthy sexual lifestyle. Group B was treated with Vrishya Modak 1 Pala or 48 g orally once a day with Anupana of Sharkara yukta Dugdha along with healthy sexual lifestyle, and Group C was treated with Vrishya Pupalika 1 Pala or 48 g orally once a day with Anupana of Sharkara yukta Dugdha along with healthy sexual lifestyle respectively for 3 months.

Results:

The results were statistically significant on various subjective parameters. In the erectile function, orgasmic function, sexual desire, intercourse satisfaction, and overall satisfaction the greatest improvement were shown in Group B, which improved by 74.28%, followed by Group C, which improved by 36.49%, and Group A, which improved by −1.99%.

Conclusion:

Based on the observations and outcomes, it is concluded that the result of Vrishya Modak was found better than placebo and Vrishya Pupalika.
Therapeutics Aspects of Apamarga Kshara (Herbomineral Formulation) in Ayurveda - A Review
Authors: Jawanjal Pravin , Patgiri Bishwajyoti
Published: September 2024

Kshara is one of the dosage forms utilizes in Ayurveda. Apamarga Kshara is prepared from alkaline ash of herbs used in Ayurveda as local and internal therapeutics. In local therapeutics, it is used in the form of Ksharasutra and as Pratisrniya Kashara. It can be also administered for internal use termed as Paniya Khara. Apamarga Kshara is a herbomineral formulation commonly used in anorectal disorders. It is used in various ailments such as warts, polyp, renal disorders calculus, nasal diseases, ear diseases, and leukoderma. The Apamarga Kshara having properties of Ksharana (debridation), Bhedana (incision), Chhedana (excision), Shodhana (purification), Stambhana (haemostatic), and Ropana (healing). Apamarga Ksharodaka is an aqueous solution of Apamarga Kshara useful in the management of warts. Apamargakshara Taila is medicated oil prepared from Acyranthes aspera and sesame oil is indicated in-ear disorder. Hence, a review of the therapeutics aspects of Apamarga Kshara is selected for the study. The present review study aimed to analyze available information from the different databases and published literature to provide information about clinical studies and case reports of Apamarga Kshara. The published clinical data suggest the safety and efficacy of Apamarga Kshara.
Hyperbaric oxygen treatment promotes tendon–bone interface healing in a rabbit model of rotator cuff tears
Authors: Li Hongqiu , Xiao Meiling , Yang Feng , Zhao Zhonghai , Liang A
Published: September 2024

Due to the high-intensity pressure that the shoulder cuff endures, it is prone to traumas and tears. The main critical function of the shoulder cuff muscles is to effectively facilitate shoulder movement and securely maintain the humeral head in the precise center of the joint cavity to prevent superior migration during abduction processes. Shoulder cuff injuries typically involve the muscle–tendon–bone interface, but existing repair techniques do not always guarantee complete and secure healing, leading to retears. Hyperbaric oxygen therapy, as an auxiliary treatment, can significantly promote the muscle–tendon–bone healing process. To explore the impact of hyperbaric oxygen therapy on the bone–tendon interface healing process in a rabbit model specifically designed for shoulder cuff tears, an experiment was conducted on New Zealand white rabbits by performing a full-thickness tear of the supraspinatus tendon in the left shoulder, followed by 2 hours per day of 100% oxygen treatment at 2 absolute atmospheres for 5 days. The results indicate that hyperbaric oxygen therapy significantly enhances vascularization at the interface between the shoulder cuff and tendon–bone, promotes collagen fiber regeneration in the tendon, improves the tensile strength of the tendon–bone complex, and does not have a significant effect on biomechanical stability. This suggests that hyperbaric oxygen therapy has a significant positive impact on the histological and biomechanical healing of shoulder cuff tears in rabbits, expediting the healing process of the tendon–bone interface.
More Than a Boarding House: Generation of Heterotopia in Harold Pinter’s The Birthday Party
Authors: Gültekin Ömer Kemal
Published: September 2024

One of the pioneering playwrights of postwar British drama, Harold Pinter is usually known for his plays’ absurd features and for his combination of elements like comedy and threat in an unprecedented way. Nevertheless, Pinter’s ingenuity cannot merely be confined to such a specific framework, and this paper explores a rather neglected main dramatic element in his most well-known and commonly-studied play The Birthday Party (1959). Taking Michel Foucault’s definition of heterotopia into consideration, this paper analyses the specific selection of a boarding house as the setting of the play and focuses on the spatial markers’ contribution to the ambiguity intentionally engendered by the playwright. Meanwhile, the status of the boarding house put under scrutiny reveals the perfectly heterotopic nature of the place. The boarding house in the play hosts a spectrum of contradictory places in its complicated constitution such as a delivery room, a hideout, a womb, and a playground. In this sense, the boarding house constitutes a catalyser which Pinter employs to further blur the relationships and the dialogue between the characters. This study, investigating all these heterotopic features in detail, once again marks the undeniable influence of the setting on the action and dialogue in a play. By putting an emphasis on the heterotopic features of the setting in The Birthday Party, it underlines the significance of the setting in denying the revelation of a unique and simple conclusion and promoting multiple ways of reading the play.
Keberadaan Mikroplastik Pada Budidaya Ikan Bawal (Colossoma macropomum) Keramba Di Sungai Kampar
Authors: Roza Elvia , Gesriantuti Novia , Badrun Yeeri
Published: September 2024

Mikroplastik merupakan hasil degradasi dan fragmentasi yang bersumber dari plastik dengan ukuran <5 mm. Saat sekarang ini banyak masyarakat yang memanfaatkan usus ayam broiler yang kemungkinan terkontaminasi oleh mikroplastik sebagai pakan ikan bawal (Colossoma macropomum) di keramba jaring apung (KJA). Tujuan dari penelitian ini untuk mengetahui jumlah dan tipe mikroplastik yang ada pada usus ayam broiler dan saluran pencernaan ikan bawal (C. macropomum) keramba dan melihat tingkat korelasi keberadaan mikroplastik yang ada pada saluran pencernaan ikan bawal (C. macropomum) yang diberi pakan menggunakan usus ayam broiler. Metode yang digunakan pada penelitian ini adalah purposive sampling untuk pengambilan sampel ikan bawal (C. macropomum) keramba. Pengambilan sampel usus ayam broiler dilakukan secara acak (random) dari pembudidaya ikan KJA di Desa Teluk Kenidai. Hasil yang diperoleh yaitu mikroplastik tipe film, fiber dan fragmen ditemukan pada usus ayam broiler dan saluran pencernaan ikan bawal (C. macropomum). Jumlah mikroplastik yang ditemukan pada usus ayam broiler yaitu 322 partikel film, 112 partikel fiber, dan 52 partikel fragmen. Sedangkan pada saluran pencernaan ikan bawal (C. macropomum) 343 partikel film, 203 partikel fiber, dan 63 partikel fragmen. Hubungan keberadaan mikroplastik pada saluran pencernaan ikan bawal (C. macropomum) yang diberi pakan menggunakan usus ayam broiler memiliki hubungan yang sangat kuat dengan nilai korelasi sebesar 0,952.
“KONTAMINASI LOGAM BERAT DI KOLOM AIR, SEDIMEN DAN DAGING IKAN NGONGAI (Bagarius bagarius) DI KAWASAN KONSERVASI BATANG KUANTAN SIJUNJUNG”
Authors: Masykury Rizka , Syandri Hafrijal , Azrita Azrita
Published: September 2024

Penelitian ini bertujuan untuk menganalisis kandungan logam berat pada kolom air, sedimen, dan daging ikan Bagarius bagarius yang hidup di kawasan konservasi sungai Batang Kuantan. Jenis logam berat yang dianalisa meliputi Hg, Pb, Cu, Zn, dan Cd. Penelitian dilaksanakan dari bulan April sampai Mei 2022 pada tiga stasiun di kawasan Konservasi Aliran Batang Kuantan Sijunjung. Analisis sampel dilakukan di Laboratorium UPTD Kesehatan Provinsi Sumatera Barat. Konsentrasi logam berat dalam kolom air, sedimen dan daging ikan ditentukan dengan spektrofotometer berdasarkan metode AAS. Hasil penelitian didapatkan bahwa pada kolom air kandungan logam berat tertinggi adalah Hg (0,015 mg/L) di stasiun 3, pada sedimen yang tertinggi adalah Zn (30.92 mg/L) di stasiun 1, sedangkan pada daging ikan yang tertinggi adalah Pb (15.51 mg/kg) ditemukan di stasiun 3. Kadar logam berat tertinggi di kolom air yaitu Hg melebihi baku mutu Baku Mutu Air Sungai dan Sejenisnya Kelas III Berdasarkan Lampiran VI Peraturan Pemerintah Republik Indonesia No. 22 Tahun 2021 Tentang Penyelenggaraan Perlindungan dan Pengelolaan Lingkungan Hidup sebesar 0,002 mg/L, sedangkan logam Cd tertinggi pada stasiun 3 sebesar 3.199 mg/kg melebihi baku mutu untuk sedimen berdasarkan Australian dan New Zaeland Environtment and Conservation Council (ANZECC, 2000) senilai 1.5 mg/kg. Pada daging ikan yaitu Pb tertinggi di stasiun 3, hal ini berarti melebihi baku mutu logam berat Pb untuk daging ikan dan hasil olahannya dalam pangan menurut SNI Nomor 7387 tahun 2009 tentang batas maksimum cemaran logam berat dalam pangan yakni 0,3 mg/kg.
Management of Whale Shark (Rhincodon typus) Based on Population Structure in Kwatisore Waters, Cenderawasih Bay National Park, Nabire Regency, Central Papua Province
Authors: Tebay Selvi , Suruan Sampari S. , Manangkalangi Emmanuel , Bawole Roni , Manuputty Agnestesya
Published: September 2024

Penelitian terhadap hiu paus (Rhincodon typus) dilakukan di perairan Kwatisore, bagian dari kawasan Taman Nasional Teluk Cenderawasih. Observasi lapangan dilakukan pada bulan September hingga Desember 2016. Tujuan penelitian adalah untuk mengetahui pengelolaan ikan hiu paus berdasarkan struktur populasi, yaitu identifikasi individu, jenis kelamin, panjang dan bekas luka. Variabel observasinya adalah struktur populasi. Pengumpulan data dilakukan dengan metode observasi langsung yang terbagi dalam 2 waktu observasi, yaitu observasi langsung oleh peneliti pada pukul 06.00-17.59 dan observasi tidak langsung oleh nelayan bagan pada pukul 18.00-05.59. Pada pengamatan langsung, pengambilan data ID setiap individu dilakukan dengan memotret sirip dada kirinya, yaitu pada area antara pangkal insang ke-5, titik tertinggi insang ke-5, dan ujung belakang sirip dada. Hasil dokumentasi diidentifikasi menggunakan software I3S2.0. Bintik putih di area tersebut menjadi kunci utama identifikasi setiap hiu paus. Melalui beberapa kali pengulangan pengamatan ID, dapat diketahui jumlah, jenis kelamin, ukuran, dan kecenderungan kemunculannya. Hasil penelitian menunjukkan ditemukannya 23 individu yaitu semuanya berjenis kelamin jantan. Teridentifikasi terdiri dari 17 individu lama dan 6 individu baru. Rata-rata panjang individu yang ditemukan adalah 3 - 4 meter. Setiap individu mempunyai frekuensi kemunculan yang berbeda-beda. Frekuensi kemunculan tertinggi adalah individu ID016 dengan panjang 6 m dan ID047 dengan panjang 3 m. Bekas luka yang ditemukan pada masing-masing tubuh hiu paus terdapat pada bagian mulut (53%), ekor (17%), dan sirip dada kanan (12%). Hiu paus harus dilestarikan secara alami pada suatu wilayah perairan tertentu, Komitmen seluruh pemangku kepentingan untuk mengembangkan sistem pengelolaan kolaboratif dalam pengelolaan sumber daya hiu paus dan habitatnya.
Tendensi Asal Sarang Penyu yang Direlokasi ke Pusat Pendidikan dan Konservasi Penyu, Serangan-Bali
Authors: Parawangsa I Nyoman Yoga , Sukanta I Made , Budi Eka Saktiawan , Utami Dhita Hardiyanti
Published: September 2024

Penyu merupakan salah satu living fossil yang masih ditemukan. Hanya terdapat 7 spesies penyu di dunia pada saat ini. Penyu telah menenui banyak ancaman, bahkan sejak masih dalam fase telur di pantai. Telur penyu dalam sarang yang berada di pantai memiliki beberapa ancaman seperti predator, pencurian, abrasi dan perubahan garis pantai yang meningkatkan tindakan relokasi sarang penyu untuk diselamatkan. Tujuan dari penelitian ini adalah untuk mengetahui kecenderungan tempat asal telur yang dipindahkan ke sarang semi alami di Pusat Konservasi dan Pendidikan Penyu, Serangan-Bali. Pengumpulan data dilakukan selama 5 tahun dari tahun 2015 sampai dengan 2019. Dalam 5 tahun jumlah sarang yang berhasil diselamatkan sebanyak 792 dan jumlah telur 87.303. Sarang telur penyu yang direlokasi ke sarang semi alami TCEC berasal dari 27 pantai habitat bersarang. Sebagian besar sarang penyu yang direlokasi berasal dari Pantai Klungkung, Pantai Serangan, dan Pantai Lembeng dengan jumlah telur penyu di masing-masing pantai adalah 211 sarang, 179 sarang, dan 174 sarang.
Pengaruh Jenis Umpan Terhadap Hasil Tangkapan Ikan Gabus (Channa striata) pada bubu di Perairan Rawa Kampung Wasur
Authors: Pane Lindon Robinson , Merly Sendy Lely , Sakap Enos , Dumatubun Nelly , Mappasessu Baso , Bokowi Dom Jimi
Published: September 2024

Potensi sumberdaya perikanan yang dimiliki oleh Kabupaten Merauke sangat tinggi, baik itu pada perairan laut dan juga perairan darat atau rawa. Meskipun demikian, perairan darat atau rawa yang dimiliki oleh Kabupaten tersebut terbilang rendah untuk dimanfaatkan. Tujuan dari penelitian ini yaitu untuk mengetahui pengaruh jenis umpan terhadap hasil tangkapan ikan terlebih khusus Gabus dengan menggunakan alat tangkap bubu. Manfaatnya agar supaya dapat memberikan informasi tambahan kepada masyarakat tentang jenis umpan yang paling disukai oleh Ikan Gabus. Penelitian ini menggunakan rancangan acak lengkap dengan perlakuan tiga jenis umpan yang berbeda yaitu semut, kodok, dan cacing. Hasil penelitian menunjukkan bahwa jenis umpan semut memiliki hasil tangkapan terbanyak dengan nilai persentase lebih dari 50 % terhadap jenis umpan yang lainnya.
Perhitungan Cepat Kelimpahan Acanthaster planci di Pulau Sombori, Morowali, Sulawesi Tengah
Authors: Zamani Nevyati P. , Subhan Beginer , Rachma ati Rita , Jansit Afifah F.
Published: September 2024

Acanthaster planci merupakan salah satu penyebab kerusakan terumbu karang paling potensial di Indonesia. Keberadaan COTs di Indonesia telah dilaporkan dengan jumlah populasi yang besar dan memangsa karang dengan jumah yang besar. Metode pemantauan yang digunakan adalah metode time swimming yang dilakukan selama 2x10 menit. Kategorisasi penentuan wabah menggunakan pendekatan ambang batas yang dikembangkan dalam program ORANET. Pemantauan kelimpahan Acanthaster planci dilakukan di tujuh lokasi dengan 10 titik pengamatan, yaitu Pulau Dongkalan Kecil sebanyak 123 Individu, Pulau Dongkalan Besar 5 Individu, Pulau Mbokita 60 Individu, Pulau Kayangan 7 Individu, Pantai Pasir Merah 5 Individu, Pantai Air Kiri 6 Individu, dan Pantai Goa Alo 6 Individu.Jumlah individu Acanthaster planci yang tinggi hanya ditemukan pada 2 pulau yaitu pulau Dongkalan Kecil dan Pulau Mbokita. Jumlah Acanthaster planci pada kedua pulau ini masuk dalam kategori memungkinkan menjadi wabah dan masuk dalam kategori mengancam Ekosistem Terumbu karang. Kondisi terumbu karang di Pulau Dongkalan kecil di dominasi oleh karang mati yang diduga akibat predasi Acanthaster planci. sedangkan di Pulau mbokita kondisi terumbu karang tidak di dominasi oleh karang mati namun terdapat banyak sisa predasi pada karang.
Keberlanjutan Wisata Pantai Tilalohe ditinjau dari Aspek Partisipasi Masyarakat
Authors: Hamzah Sri Nuryatin , Panigoro Citra , Nago Ludgardis Fibriyanti
Published: September 2024

Wisata bahari merupakan pemanfaatan sumber daya alam pesisir dan bentang alam laut yang dijadikan sebagai tempat wisata, sehingga wisata pantai menjadi salah satu destinasi wisata favorit di Indonesia. Pemanfaatan sumber daya alam sebagai suatu kegiatan wisata, berdampak pada pemenuhan kebutuhan baik bagi pemangku kepentingan maupun masyarakat sekitar tempat wisata. Namun saat ini, banyak tempat wisata yang tidak melibatkan masyarakat sebagai mitra kerja, padahal masyarakat sekitar lokasi wisata yang merasakan langsung dampak positif dan negatif dari keberadaan wisata itu sendiri. Oleh karena itu, masyarakat dapat menjadi salah satu penentu dari sistem keberlanjutan suatu pariwisata. Penelitian ini bertujuan untuk mengetahui keberlanjutan wisata Pantai Tilalohe, ditinjau dari aspek partisipasi masyarakat. Metode pengumpulan data yang digunakan dalam penelitian ini, yaitu observasi, wawancara dan kuesioner, sedangkan metode analisis data menggunakan analisis skala likert. Hasil penelitian menunjukkan bahwa keberlanjutan wisata Pantai Tilalohe, ditinjau dari aspek partisipasi masyarakat termasuk dalam kriteria baik.