bluuebunny/crossref_metadata_2025 huggingface dataset:
Clinical impact of number of lymph nodes dissected on postoperative survival in node-negative small cell lung cancer
Authors: Takamori Shinkichi , Komiya Takefumi , Powell Emily
Published: November 2022

Objectives

Small cell lung cancer (SCLC) is a lethal histologic subtype of lung cancer. Although the Commission on Cancer recommends pathological examination of at least 10 lymph nodes dissected (LNDs) for resected early-stage non-small cell lung cancer, its survival benefit of LNDs in patients with early-stage SCLC is unknown.

Methods

The National Cancer Database was queried for SCLC patients with clinical stage I-II and clinical N0, NX disease per AJCC 7th edition who had undergone lobectomy between 2004 and 2017. Overall survival of SCLC patients by the number of LNDs was compared using Log-rank tests. Univariate and multivariable Cox proportional hazards analyses were performed.

Results

In total, 688 (42%), 311 (20%), 247 (16%), 196 (12%), 126 (8%), and 36 (2%) of 1,584 patients with early-stage SCLC had ≥10, 7-9, 5-6, 3-4, 1-2, and 0 LNDs, respectively. The sequential improvement in the HRs was no longer evident if the number of LNDs exceeds 4. Patients with ≥3 LNDs (n = 1,422) had a significantly longer overall survival than those with <3 LNDs (n = 162) (hazard ratio for death: 0.76, 95% confidence interval: 0.62–0.94, P = 0.0087). Multivariate analysis revealed that ≥3 LNDs was an independent factor for predicting overall survival (hazard ratio for death: 0.76, 95% confidence interval: 0.61–0.93, P = 0.0083).

Conclusions

Although we are reluctant to recommend a definitive “optimal number” of LNDs, our findings suggest the prognostic and therapeutic roles for performing ≥3 LNDs in patients with early-stage SCLC who undergo lobectomy.
Prognostic analysis of radical resection for iCCAphl and iCCApps: A retrospective cohort study
Authors: Yu Zetao , Ni Qingqiang , Jia Hongtao , Gao Hengjun , Yang Faji , Zhu Huaqiang , Liu Fangfeng , Wang Jianlu , Zhou Xu , Chang Hong , Lu Jun
Published: November 2022

Backgroud

At present, there is no definitive conclusion about the relative prognostic factors on intrahepatic cholangiocarcinoma perihilar large duct type (iCCAphl) and iCCA peripheral small duct type (iCCApps).

Aim of the study

To compare the prognoses of two different types of iCCA, and identify the independent risk factors affecting the long-term survival of patients undergoing radical resection for iCCA.

Methods

This study included 89 patients with iCCA who underwent radical resection at the Department of Hepatobiliary Surgery of the East Yard of the Shandong Provincial Hospital between January 2013 and March 2022. According to the tumor origin, these patients were divided into the iCCAphl group (n = 37) and iCCApps group (n = 52). The prognoses of the two groups were compared using Kaplan–Meier analysis, whereas the independent risk factors of their prognoses were identified using Cox univariate and multivariate regression analyses.

Results

In the iCCApps group, the independent risk factors for overall survival included diabetes history (p = 0.006), lymph node metastasis (p = 0.040), and preoperative carbohydrate antigen 19-9 (p = 0.035). In the iCCAphl group, the independent risk factors for overall survival included multiple tumors (p = 0.010), tumor differentiation grade (p = 0.008), and preoperative jaundice (p = 0.009).

Conclusions

Among the iCCA patients who underwent radical resection, the long-term prognosis of iCCApps maybe better than that of iCCAphl. The prognoses of these two types of iCCA were affected by different independent risk factors.
Clinical presentation and transmission of postnatal cytomegalovirus infection in preterm infants
Authors: Lee Jun Eon , Han Yea Seul , Sung Tae-Jung , Kim Dong Hyun , Kwak Byung Ok
Published: November 2022

Background

Preterm infants are at greater risk of developing postnatal cytomegalovirus (CMV) infection with serious symptoms. Breast milk is the main route of CMV transmission in populations with a high seroprevalence.

Objectives

This study aimed to investigate the clinical presentation and transmission of postnatal CMV (pCMV) infection via breast milk in preterm infants under the specific setting of our neonatal intensive care unit (NICU).

Methods

The medical records of 147 preterm infants were reviewed retrospectively, and their clinical characteristics and outcomes were analyzed. Breast milk and infant urine samples were collected every two weeks until discharge, and the kinetics of CMV loads were evaluated using a polymerase chain reaction assay.

Results

Seventeen infants (11.6%) were diagnosed with pCMV infection during the study period. In comparison between the pCMV and control groups, the mean birth weight was significantly lower in the pCMV group than in the control group (1084.1 ± 404.8 g vs. 1362.5 ± 553.8 g, P = 0.047). Four (23.5%) patients had leukocytopenia, six (35.3%) had neutropenia, three (17.6%) had thrombocytopenia, and two (11.8%) had hyperbilirubinemia in the pCMV group. Five patients were treated with antiviral agents, and their CMV load in the urine decreased after treatment. CMV loads peaked at 3–5 weeks in breast milk, whereas they peaked at 8–12 weeks of postnatal age in infants' urine. A comparison between the median CMV load in breast milk from the pCMV and control groups revealed a significant difference (P = 0.043).

Conclusion

Most preterm infants with pCMV infection present a favorable clinical course and outcomes. A high CMV viral load in breast milk is associated with transmission. Further studies are warranted to prevent transmission and severe pCMV infections in preterm infants.
Can bacterial lysates be useful in prevention of viral respiratory infections in childhood? The results of experimental OM-85 studies
Authors: Ballarini Stefania , Ardusso Ledit , Ortega Martell José Antonio , Sacco Oliviero , Feleszko Wojciech , Rossi Giovanni A.
Published: November 2022

Respiratory tract infections (RTI) are mainly viral in origin and among the leading cause of childhood morbidity globally. Associated wheezing illness and asthma are still a clear unmet medical need. Despite the continuous progress in understanding the processes involved in their pathogenesis, preventive measures and treatments failed to demonstrate any significant disease-modifying effect. However, in the last decades it was understood that early-life exposure to microbes, may reduce the risk of infectious and allergic disorders, increasing the immune response efficacy. These results suggested that treatment with bacterial lysates (BLs) acting on gut microbiota, could promote a heterologous immunomodulation useful in the prevention of recurrent RTIs and of wheezing inception and persistence. This hypothesis has been supported by clinical and experimental studies showing the reduction of RTI frequency and severity in childhood after oral BL prophylaxis and elucidating the involved mechanisms. OM-85 is the product whose anti-viral effects have been most extensively studied in vitro, animal, and human cell studies and in translational animal infection/disease models. The results of the latter studies, describing the potential immune training-based activities of such BL, leading to the protection against respiratory viruses, will be reported. In response to human rhinovirus, influenza virus, respiratory syncytial virus and severe acute respiratory coronavirus-2, OM-85 was effective in modulating the structure and the functions of a large numbers of airways epithelial and immune cells, when administered both orally and intranasally.
Pediatric isoniazid-resistant tuberculosis of the bone marrow manifesting as hemophagocytic syndrome: A case report
Authors: Zheng Junfeng , Xu Yongbin , Yang Jun , Cao Ke , Deng Guofang , Zhang Peize
Published: November 2022

Hemophagocytic syndrome (HPS) is a critical syndrome of ineffective hyperinflammatory immune response resulting in infiltration of lymphocytes and histiocytes in various organs. Causes can be hereditary or due to malignancy, autoimmune disease, or infection. HPS due to Mycobacterium tuberculosis is rare as only a handful of cases are reported, and they are mostly associated with severe disseminated tuberculosis (TB). We reported a 9-year-old boy with tuberculosis of the bone marrow accompanied with hemophagocytic syndrome. The patient presented with manifestation of HPS and had no respiratory symptoms or risk factors for TB but was later diagnosed of isoniazid-resistant TB in the bone marrow. He had a good outcome after receiving anti-TB drugs and corticosteroids on time. This case highlights that bone marrow might be a shelter for Mycobacterium tuberculosis. Concurrent testing for drug susceptibility in TB cases with an uncommon manifestation is recommended even for first episodes. Early diagnosis and etiological confirmation of the infection origin and appropriate treatment are essential to improve survival in this otherwise life-threatening condition.
Role of potential bioactive metabolites from traditional Chinese medicine for type 2 diabetes mellitus: An overview
Authors: Li Xiang , Geng-Ji Jia-Jia , Quan Yun-Yun , Qi Lu-Ming , Sun Qiang , Huang Qun , Jiang Hai-Mei , Sun Zi-Jian , Liu Hong-Mei , Xie Xin
Published: November 2022

Type 2 diabetes mellitus (T2DM) is a metabolic disease with persistent hyperglycemia primarily caused by insulin resistance (IR). The number of diabetic patients globally has been rising over the past decades. Although significant progress has been made in treating diabetes mellitus (DM), existing clinical drugs for diabetes can no longer fully meet patients when they face complex and huge clinical treatment needs. As a traditional and effective medical system, traditional Chinese medicine (TCM) has a unique understanding of diabetes treatment and has developed many classic and practical prescriptions targeting DM. With modern medicine and pharmacy advancements, researchers have discovered that various bioactive metabolites isolated from TCM show therapeutic on DM. Compared with existing clinical drugs, these bioactive metabolites demonstrate promising prospects for treating DM due to their excellent biocompatibility and fewer adverse reactions. Accordingly, these valuable metabolites have attracted the interest of researchers worldwide. Despite the abundance of research works and specialized-topic reviews published over the past years, there is a lack of updated and systematic reviews concerning this fast-growing field. Therefore, in this review, we summarized the bioactive metabolites derived from TCM with the potential treatment of T2DM by searching several authoritative databases such as PubMed, Web of Science, Wiley Online Library, and Springer Link. For the convenience of readers, the content is divided into four parts according to the structural characteristics of these valuable compounds (flavonoids, terpenoids, alkaloids, and others). Meanwhile, the detailed mechanism and future directions of these promising compounds curing DM are also summarized in the related sections. We hope this review inspires increasingly valuable and significant research focusing on potential bioactive metabolites from TCM to treat DM in the future.
Protein-protein interactions between RUNX3 and ZEB1 in chronic lung injury induced by methamphetamine abuse
Authors: Bao Ning , Cheng Lin , Wang Yun , Peng Zhe , Wang Zhengkun , Chen Shuangquan
Published: November 2022

Methamphetamine (MA) is the most common and highly addictive substance abuse drug. Runt-related transcription factor 3 (RUNX3) and Zinc finger E-box-binding homeobox 1 (ZEB1) are associated with lung inflammation and fibrosis. However, the protein-protein interactions (PPIs) between RUNX3 and ZEB1 and its involvement in MA-induced chronic lung injury is still unclear. In this study, we evaluated lung injury using echocardiography, hematoxylin and eosin staining, and western blot analysis. The viability of alveolar epithelial cells (AECs) was assessed using cell counting kit-8. Molecular Operating Environment software, Search Tool for the Retrieval of Interacting Genes/Proteins database, co-immunoprecipitation, assay and confocal immunofluorescence assay were used to predict and identify the PPIs between RUNX3 and ZEB1. The expression of RUNX3 and ZEB1 were knockdown in AECs using siRNA. The results revealed that MA exposure increased the peak blood flow velocity of the pulmonary artery and the acceleration time of pulmonary artery blood flow. Further, exposure to MA also causes adhesion and fusion of the alveolar walls and altered AEC activity. A decrease in the expression of RUNX3 and an increase in the expression of ZEB1 and its downstream signaling molecules were observed on MA exposure. The PPIs between RUNX3 and ZEB1 were identified. Further, an increase in the protein binding rate of RUNX3-ZEB1 was observed in MA-induced lung injury. These results show interactions between RUNX3 and ZEB1. RUNX3 protects against lung injury; however, ZEB1 expression and the PPIs between ZEB1 and RUNX3 has deleterious effects on chronic lung injury induced by MA exposure. Our results provide a new therapeutic approach for the treatment of chronic lung injury due to MA exposure.
The power of innate: Behavioural attachment and neural activity in responses to natural and artificial objects in filial imprinting in chicks
Authors: Cherepov A. B. , Tiunova A. A. , Anokhin K. V.
Published: November 2022

Newly hatched domestic chicks are known to orient preferentially toward naturalistic stimuli, resembling a conspecific. Here, we examined to what extent this behavioral preference can be transcended by an artificial imprinting stimulus in both short-term and long-term tests. We also compared the expression maps of the plasticity-associated c-fos gene in the brains of chicks imprinted to naturalistic (rotating stuffed jungle fowl) and artificial (rotating illuminated red box) stimuli. During training, the approach activity of chicks to a naturalistic object was always higher than that to an artificial object. However, the induction of c-fos mRNA was significantly higher in chicks imprinted to a box than to a fowl, especially in the intermediate medial mesopallium, hyperpallium apicale, arcopallium, and hippocampus. Initially, in the short-term test (10 min after the end of training), chicks had a higher preference for a red box than for a stuffed fowl. However, in the long-term test (24 h after imprinting), the response to an artificial object decreased to the level of preference for a naturalistic object. Our results thus show that despite the artificial object causing a stronger c-fos novelty response and higher behavioral attachment in the short term, this preference was less stable and fades away, being overtaken by a more stable innate predisposition to the naturalistic social object.
Extracellular vesicles: A potential future strategy for dental and maxillofacial tissue repair and regeneration
Authors: Liu Ziwei , Wang Situo , Huo Na , Yang Shuo , Shi Quan , Xu Juan
Published: November 2022

Extracellular vesicles (EVs), nano-sized bilayer membrane structures containing lipids, proteins and nucleic acids, play key roles in intercellular communication. Compared to stem cells, EVs have lower tumorigenicity and immunogenicity, are easier to manage and cause fewer ethic problems. In recent years, EVs have emerged as a potential solution for tissue regeneration in stomatology through cell-free therapies. The present review focuses on the role of EVs in dental and maxillofacial tissue repair and regeneration, including in dental and periodontal tissue, maxilla and mandible bone, temporomandibular joint cartilage, peripheral nerve and soft tissue. We also make a brief overview on the mechanism of EVs performing functions. However, limitations and challenges in clinical application of EVs still exist and should be addressed in future researches.
The bidirectional relationship between AMPK pathway activation and myokine secretion in skeletal muscle: How it affects energy metabolism
Authors: Ahsan Mahdi , Garneau Léa , Aguer Céline
Published: November 2022

Myokines are peptides and proteins secreted by skeletal muscle cells, into the interstitium, or in the blood. Their regulation may be dependent or independent of muscle contraction to induce a variety of metabolic effects. Numerous myokines have been implicated in influencing energy metabolism via AMP-activated protein kinase (AMPK) signalling. As AMPK is centrally involved in glucose and lipid metabolism, it is important to understand how myokines influence its signalling, and vice versa. Such insight will better elucidate the mechanism of metabolic regulation during exercise and at rest. This review encompasses the latest research conducted on the relationship between AMPK signalling and myokines within skeletal muscles via autocrine or paracrine signalling.
Autoimmunity as a sequela to obesity and systemic inflammation
Authors: Kwiat Victoria R. , Reis Gisienne , Valera Isela C. , Parvatiyar Kislay , Parvatiyar Michelle S.
Published: November 2022

The rising prevalence of obesity presents a world-wide challenge as it is associated with numerous comorbidities including cardiovascular disease, insulin resistance and hypertension. Obesity-associated illnesses are estimated to cause nearly 4 million deaths globally per year, therefore there is a critical need to better understand associated pathogenesis, identify new therapeutic targets, and develop new interventions. Emerging data identify a key role for chronic inflammation in mediating obesity related disease states and reveal higher incidence of autoimmune disease development. Of the multiple potential mechanisms linking obesity and autoimmunity, the strongest link has been shown for leptin, a hormone secreted at high levels from obese white adipose tissue. Numerous studies have demonstrated that leptin enhances activation of both arms of the immune system, while its absence protects against development of autoimmunity. Other potential newly discovered mechanisms that contribute to autoimmune pathogenesis are not directly connected but also associated with obesity including sustained platelet activation, gut dysbiosis, and aging. Here we review how obesity instigates autoimmunity, particularly in the context of immune cell activations and adipokine secretion.
Using leaf spectroscopy and pigment estimation to monitor indoor grown lettuce dynamic response to spectral light intensity
Authors: Cammarisano Laura , Graefe Jan , Körner Oliver
Published: November 2022

Rising urban food demand is being addressed by plant factories, which aim at producing quality food in closed environment with optimised use of resources. The efficiency of these new plant production systems could be further increased by automated control of plant health and nutritious composition during cultivation, allowing for increased produce value and closer match between plant needs and treatment application with potential energy savings. We hypothesise that certain leaf pigments, including chlorophylls, carotenoids and anthocyanins, which are responsive to light, may be good indicator of plant performance and related healthy compounds composition and, that the combination of leaf spectroscopy and mathematical modelling will allow monitoring of plant cultivation through noninvasive estimation of leaf pigments. Plants of two lettuce cultivars (a green- and a red-leaf) were cultivated in hydroponic conditions for 18 days under white light spectrum in climate controlled growth chamber. After that period, plant responses to white light spectrum (‘W’) with differing blue wavelengths (‘B’, 420 - 450 nm) percentage (15% ‘B15’, and 40% ‘B40’) were investigated for a 14 days period. The two light spectral treatments were applied at photon flux densities (PFDs) of 160 and 240 µmol m-2 s-1, resulting in a total of four light treatments (160WB15, 160WB40, 240WB15, 240WB40). Chlorophyll a fluorescence measurements and assessment of foliar pigments, through destructive (in vitro) and non-destructive (in vivo) spectrophotometry, were performed at 1, 7 and 14 days after treatment initiation. Increase in measured and estimated pigments in response to WB40 and decrease in chlorophyll:carotenoid ratio in response to higher PFD were found in both cultivars. Cultivar specific behavior in terms of specific pigment content stimulation in response to time was observed. Content ranges of modelled and measured pigments were comparable, though the correlation between both needs to be improved. In conclusion, leaf pigment estimation may represent a potential noninvasive and real-time technique to monitor, and control, plant growth and nutritious quality in controlled environment agriculture.
Motor skills and cognitive benefits in children and adolescents: Relationship, mechanism and perspectives
Authors: Shi Peng , Feng Xiaosu
Published: November 2022

Objective

There is a strong interaction between motor skills and cognitive benefits for children and young people. The aim of this paper is to explore the relationship between motor skill types and their development and the cognitive benefits of children and adolescents. In turn, on this basis, it proposes pathways and mechanisms by which motor skills improve cognition, and provide a basis for subsequent teaching of skills that follow the laws of brain cognitive development.

Methods

This paper summarizes the research on the relationship between different types of motor skills and their development and cognitive benefits of children and adolescents. Based on these relationships, pathways, and mechanisms for motor skills to improve cognition are tentatively proposed.

Results

There is an overall pattern of “open > closed, strategy > interception, sequence > continuous” between motor skill types and the cognitive benefits of children and adolescents. Long-term motor skill learning practice is accompanied by increased cognitive benefits as skill proficiency increases. The dynamic interaction between motor skills and physical activity exposes children and adolescents to environmental stimuli and interpersonal interactions of varying complexity, promoting the development of agility, coordination and cardiorespiratory fitness, enhancing their motor experience, which in turn improves brain structure and functional activity.

Conclusion

Motor skills training promote cognitive efficiency in children and adolescents. Motor skill interventions that are open-ended, strategic and sequential in nature are more effective. Environmental stimuli, interpersonal interaction, agility, coordination, and cardiorespiratory fitness can be considered as skill attribute moderators of motor skills to improve cognition.
Construct validity of questionnaires for the original and revised reinforcement sensitivity theory
Authors: Leue Anja , Reuter Martin , Corr Philip J. , Ettinger Ulrich
Published: November 2022

This study highlights psychometric properties and evidence of construct validity on parcel-level for questionnaires on the original and revised reinforcement sensitivity theory. Our data (N = 1,076) suggest good to very good psychometric properties and moderate to excellent internal consistencies. Confirmatory factor analysis (CFA) models suggest a very good model fit for the first-order, four factor models of the Carver-White BIS/BAS scales, Reinforcement Sensitivity Theory – Personality Questionnaire (RST-PQ), the two-factor model of revised Reinforcement Sensitivity Theory-Questionnaire (rRST-Q) and for the bifactor model of the Conflict Monitoring Questionnaire (CMQ-44). The CMQ-44 extends the psychometric measurement of previous trait-(r)BIS and trait-BAS scales. Factor scores of CMQ-44 cognitive demand correlate positively with factor scores of Carver-White BIS and all Carver-White BAS subfactors except RST-PQ-Impulsivity suggesting that CMQ-44 cognitive demand addresses Carver-White trait-BIS specifically and more generally the trait-BAS core. CMQ-44 anticipation of negative consequences and response adaptation correlate negatively with trait-BAS, whereas the second-order factor performance monitoring extends the rRST trait-space and correlates positively with trait-BAS.
Association between noise exposure during pregnancy and pregnancy complications: A meta-analysis
Authors: Wang Zihao , Qian Rongkai , Xiang Wanwan , Sun Landi , Xu Mengmeng , Zhang Boxing , Yang Liren , Zhu Sijing , Zeng Lingxia , Yang Wenfang
Published: November 2022

Background

Noise exposure has a significant impact on human health. However, the effect of occupational and residential noise on the risk of pregnancy complications was controversial in the literature. This study looked at previous research and performed a meta-analysis to determine how noise exposure during pregnancy affected the risk of pregnancy complications.

Methods

Systematic searches were conducted in PubMed, Web of Science, Scopus, Embase, Ovid, and Cochrane, and all relevant studies were included. Two investigators independently evaluated the eligibility of these studies. The risk of bias in each study and the quality and strength of each outcome was evaluated by using the GRADE approach and Navigation Guide. Random effects meta-analysis model was used.

Results

The meta-analysis retrieved 1,461 study records and finally included 11 studies. Occupational noise exposure during pregnancy was associated with preeclampsia (RR = 1.07, 95%CI: 1.04, 1.10). Neither occupational nor residential noise exposure was associated with hypertensive disorders of pregnancy (HDP) (RR = 1.10, 95%CI: 0.96, 1.25 and RR = 1.05, 95%CI: 0.98, 1.11) or gestational diabetes mellitus (GDM) (RR = 0.94, 95%CI: 0.88, 1.00 and RR = 1.06, 95%CI: 0.98, 1.16). Further bias analysis showed that the results were reliable. All outcomes were rated as low in quality and inadequate evidence of harmfulness in strength.

Conclusions

Occupational noise exposure could increase the risk of preeclampsia, according to the findings. There was no clear evidence of a harmful effect of noise exposure during pregnancy on HDP or GDM.
Environmental awareness and environmental information disclosure: An empirical study based on energy industry
Authors: Wang Shijin , Zhou Ziwen , Tian Keqin
Published: November 2022

Environmental protection and governance have become a topic of global concern. Sustainable development and green development are the unshakable ideas of China’s social and economic development. Under this premise, the energy industry, as a pillar industry in China, has the disadvantages of high energy consumption and heavy pollution. Therefore, the quality of environmental information disclosure in energy industry needs to be improved urgently. This paper selects 66 samples from 22 energy companies in Shanghai and Shenzhen stock markets from 2018 to 2020 as the research object, establishes two potential variables and 13 observed variables of environmental awareness and environmental information disclosure respectively, and constructs structural equation model to study the impact of corporate environmental awareness on environmental information disclosure. The research shows that the environmental awareness of enterprises is positively related to the level of environmental information disclosure. The conclusion is helpful to improve the enthusiasm and consciousness of energy companies to disclose environmental information. A better role in supervising the quality of environmental information disclosure by the government, enterprises and the public can be played.
The mediating role of self-continuity on the link between childhood adversity and loneliness in later life
Authors: Lampraki Charikleia , Jopp Daniela S. , Spini Dario
Published: November 2022

Many factors may influence adaptation to critical life events such as divorce and bereavement in the second half of life, including having faced childhood adversity. However, pathways to reduced adaptation success are poorly understood. Self-continuity, an identity mechanism that incorporates life changes into a coherent life story, may contribute to better adaptation to adult critical life events, such as feeling less socially and emotionally lonely. We investigated the mediating role of self-continuity channeling the effects of childhood adversity on later life adaptation outcomes among individuals who had experienced divorce or bereavement. Data were derived from the longitudinal LIVES Intimate Partner Loss Study conducted in Switzerland from 2012 to 2016. The sample consisted of individuals who had experienced divorce (n = 416, Mage = 57.35) or bereavement (n = 339, Mage = 71.36) in later life, and a continuously married control group (n = 925, Mage = 67.04). Multilevel moderated mediations were used. Self-continuity mediated the effect of childhood adversity on emotional loneliness for all marital groups, but to a greater extent among divorcees. Self-continuity also mediated the effect of childhood adversity on social loneliness; however, this effect did not differ by marital group. In conclusion, childhood adversity was associated to greater loneliness in later life through self-continuity. Divorcees were the most impacted group regarding emotional loneliness, as they experienced lower levels of self-continuity. Interventions that aim to reinforce self-continuity may help overcome social and emotional loneliness, especially for individuals who have experienced the loss of their partner through divorce.
E-Portfolios for self-regulated and co-regulated learning: A review
Authors: Lam Ricky
Published: November 2022

The reflective component of e-Portfolios is said to help students improve second or foreign language writing in terms of motivation and academic results. Despite this positive advocacy, scholars remain unclear about how e-Portfolios can develop students’ self-regulatory abilities in writing classrooms, especially when students engage in complex e-Portfolio construction processes with peers, parents, teachers, their community, digital tools, and online resources. Recently, researchers have argued that not only do e-Portfolios promote self-regulated learning, but they also support co-regulation of learning wherein the latter is socially mediated by curriculum design, instructional materials, and in-class interaction patterns. Indeed, students’ inner development of self-regulatory capacity is closely influenced by external forces, which deserve more scholarly investigation. The review fills this gap by emphasizing that besides self-regulated learning, e-Portfolios can support students’ co-regulation of learning by way of their connectivity, visibility, and circulation. This review has four sections. The first section defines key concepts, namely e-Portfolios, self-regulated, co-regulated, and socially shared-regulated learning, and introduces how e-Portfolios foster self-regulation of learning in second language writing. The second section unpacks two conceptual models that underpin self-regulated and co-regulated learning relating to e-Portfolios. The third section presents a brief review, showcasing how e-Portfolios featuring self-regulation of learning can also support co-regulation of learning. The final section recommends strategies that facilitate self-regulation and co-regulation of learning in e-Portfolios reciprocally, and discusses implications for pedagogy and research.
Celebrity CEOs and firm innovation investment: Evidence from Chinese-listed companies
Authors: Shao Dong , Lv Kangyin , Zhao Shukuan , Wang Shuang
Published: November 2022

In today’s commercial-oriented world, intense social attention makes it easier for CEOs to become celebrities. This social escalation and characteristic change of CEOs into celebrities tend to influence their motivation and behavior, and thus the strategic decisions and results of firms. Despite the significance of recognizing CEOs’ social identity, the impact of celebrity CEOs on innovation strategy remains unknown. Integrating identity and upper echelons theories, this study examines and provides empirical evidence on how celebrity CEOs affect firm innovation investment using data of Chinese listed companies from 2015 to 2020. We argue that celebrity CEOs’ engagement in innovation investment is driven by their motivation for preserving celebrity status. Further, we show that analyst coverage plays a positive moderating role between celebrity CEOs and innovation investment, and the positive effect of celebrity CEOs on innovation investment becomes weaker in state-owned enterprises. This study confirms the important role of CEOs’ specific social identity in firm innovation strategy, which is motivated by celebrity CEOs’ attempt to maintain their established status and reputation. The results expand the research on the influencing factors of firm innovation investment that focus on executives’ social characteristics. They also provide managerial implications for board of directors to recruit and supervise a celebrity CEO.
Mechanisms of recovery: Community perceptions of change and growth following multiple disasters
Authors: Osofsky Howard , Osofsky Joy , Saltzman Leia Y. , Lightfoot Estilla , De King Jule , Hansel Tonya C.
Published: November 2022

Introduction and purpose

The geographic location of the Gulf South leaves communities in continuous threat, response, and recovery disaster cycles. Hurricane Katrina in 2005 provided an opportunity to study disaster mental health. Less than 5 years after the storm, many Hurricane Katrina survivors were impacted again by the Deepwater Horizon Gulf oil spill. Despite adversities impacting Gulf communities, over 90% of participants reported they were resilient. The purpose of this study was to improve the understanding of the mechanisms that contribute to strengths following adversity in communities affected by repeated disasters. Specifically, we focused on survivor perceptions of personal, spiritual, or community changes in efforts to describe community resilience and posttraumatic growth (PTG).

Methods

Participants were recruited through a quantitative survey and community flyers. Participants represented southeastern Louisiana, in areas impacted by hurricanes and the oil spill—for a total of five focus groups and 41 participants. Focus groups began by asking each participant to provide a brief overview of their disaster survival story and three additional guiding strengths-based questions. Data were transcribed using Dragon Speech Recognition software. A total of 963 unique responses were analyzed and coded.

Results

The following themes were identified: connectedness (n = 259), coping (n = 94), spirituality (n = 60), adaptability (n = 47), and self-reliance (n = 23). Participants noted a growth mindset from the disasters and also acknowledged coinciding negative experiences (n = 154) associated with community change and loss, where subthemes included change in connectedness (n = 97), crime (n = 26), and feeling like an outsider (n = 31).

Discussion and implications

These findings help scholars and mental health practitioners better understand the lived experiences of PTG in a community of survivors impacted by recurring traumatic experiences. In keeping with previous literature, PTG and negative experiences associated with trauma are not mutually exclusive, but occur simultaneously. Our results offer a holistic picture of coping with cumulative or repeated traumas and suggest that connectedness, coping, and spirituality provide important buffers to negative psychosocial outcomes.
Risk cognition, agricultural cooperatives training, and farmers' pesticide overuse: Evidence from Shandong Province, China
Authors: Ren Zhong , Jiang Haonan
Published: November 2022

Introduction

Pesticides are widely and excessively used in the world. Reducing pesticide overuse is an important measure to protect the environment and human health.

Methods

Based on the survey data of 518 farmers in Shandong Province, China, using the Logit model to empirically test the effect of risk cognition on farmers' pesticide overuse behavior and the moderating effect of cooperatives training on the effect of risk cognition on farmers' pesticide overuse behavior.

Results and discussion

We found that 21.24% of farmers overused pesticides. The three dimensions of risk cognition have significant negative effects on farmers' behavior of excessive pesticide use, among which the human health risk cognition has the largest impact (0.74), followed by food safety risk cognition (0.68) and ecological environment risk cognition (0.63). Cooperatives training has a positive moderating effect on the relationship between risk cognition and pesticide overuse behavior, that is, when risk cognition matches farmers participating in cooperatives training, the effect on reducing pesticide overuse is more significant. Years of education, planting scale and detection frequency of pesticide residues have significant effects on farmers' pesticide overuse.

Conclusions

The government should help farmers reduce pesticide overuse by improving risk cognition, developing agricultural cooperatives and perfecting guarantee conditions.
Identification and assessment of stress and associated stressors among veterinary students in India using a cross-sectional questionnaire survey
Authors: Grakh Kushal , Panwar Diksha , Jadhav Vijay Jayawant , Khurana Rajesh , Yadav Dheeraj , Bangar Yogesh Chandrakant , Singh Lokender , Chahal Niharika , Kumar Kamal
Published: November 2022

Background

Veterinary education, is a rigorous professional training program, which exposes students to significant academic and non-academic pressures. The identification of stressors and stress levels among veterinary students mighty help the designing and implementation of coping strategies to protect the students' mental health.

Methods

A 44-item based cross-sectional questionnaire survey was prepared and disseminated among veterinary students in India to identify the stressors responsible, measure the amount of stress, and relate stress to characteristics like gender, degree year, and family income. A total of n = 611 veterinary students across 14 states including 27 colleges/universities participated in the study. The collected data was evaluated for sampling adequacy, construct validity, and reliability using a set of statistical tests.

Results

The analysis revealed high sampling adequacy with a KMO value of 0.957 and a highly significant anti-image correlation (p < 0.001). The principal component analysis generated six factors or subscales which effectively explained 51.98% of the variance in the data, depicting high construct validity. The Cronbach's alpha value of 0.957 revealed high internal consistency for the questionnaire. Analysis revealed more than 94% of pupils under stress, with levels ranging from moderate to severe. Academic-related stressor (95.58%) was the leading cause of overall stress in the present study followed by inter- and intrapersonal and career related-stressors (93.12%) and exams and evaluation-related stressor (90.99%). In comparison to male students, female students reported significantly higher levels of overall stress, academic stress, and intrapersonal and interpersonal stress (p < 0.001) using Chi-square. The students from lower-income families experienced significantly higher overall stress as well as stress due to family responsibilities (p < 0.001). The first-year undergraduate students reported significantly higher (p < 0.001) stress due to family responsibilities-related stressors whereas second-year students due to social activities-related stressors. The hierarchal regression model predicted that gender, family income, academic-related stressors, inter- and intrapersonal and career-related stressors, and social activities-related stressors can be employed to evaluate overall stress among students, as they ensured the maximum variance in the data (p < 0.001).

Conclusions

To the best of our knowledge, this is the first Indian study to identify stressors, quantify associated stress and predict major attributes to be targeted in future studies for veterinary students.
COVID-19 and the beef market in Latin America: An impact assessment by supply and demand
Authors: Mejía Tejada Daniela , Díaz Manuel Francisco , Enciso Valencia Karen Johanna , Junca Paredes Jhon Jairo , Sandoval Danny Fernando , Burkart Stefan
Published: November 2022

The impact of COVID-19 on agricultural markets, especially the beef market, represents one of the greatest food security challenges the world is facing in the post-pandemic era and, for this reason, has been widely documented. This study contributes to the literature through a comprehensive impact analysis of the effects of COVID-19 on both the demand and supply of beef in Latin America and thus provides valuable information for two of the most important links of the beef value chain. Robust econometric methods and a graphic analysis were used that give solidity to the investigation. The analysis used a data panel of supply and demand variables between 2018 and 2022 derived from the US Department of Agriculture. The results suggest that the beef market was strongly affected by the pandemic related health emergency, presenting decreases in both consumption and production. These effects are transitory, however, since the analysis of the post-pandemic data revealed that consumption and production return to normal and seem to grow until smoothing out over time.
Seroprevalence of visceral leishmaniasis and its associated factors among asymptomatic pastoral community of Dire District, Borena zone, Oromia Region, Ethiopia
Authors: Ketema Haile , Weldegebreal Fitsum , Gemechu Abdella , Gobena Tesfaye
Published: November 2022

Visceral leishmaniasis (VL) is a vector-borne protozoan neglected tropical disease. In some parts of Ethiopia, it is a public health problem and its main causative agent is the Leishmania donovani complex. The objective of the study was to determine the seroprevalence of VL and factors associated among the asymptomatic pastoral community of Dire District, Borena Zone, Oromia Region, Ethiopia. A community-based study was conducted among 432 pastoralist communities from June to July 2021. A systematic random sampling method was used to select households. Pretested structured questionnaires and face-to-face interviews were used to collect data. A single finger-prick blood sample was collected and tested for Leishmania donovani complex using an immune-chromatographic test (rk39-ICT). A logistic regression model was used to assess factors associated with VL infection and a p-value of < 0.05 was considered statistically significant. A total of 432 study participants were included (their mean age was 26.69) and 218 (50.5%) were females. The overall seroprevalence of VL was 33/432(7.6%) (95%CI: 5.32–15.60). Sero-prevalence was significantly associated with high family size (>5) (adjusted odds ratios (AOR) = 5.134; 95% CI: 2.032–9.748), sleeping or/and staying under acacia tree (AOR = 2.984; 95%CI = 1.074–8.288), presence of cracked house walls (AOR = 1.801; 95%CI: 1.026–4.926), presence of termite hills (AOR = 1.938; 95%CL: 1.002–7.050), availability of water points (AOR = 3.893; 95%CI: 1.034–7.426) and presence of domestic animals (AOR = 2.124; 95% CI: 2.341–5.108). It is recommended that community awareness on the transmission and prevention methods of Leishmania donovani complex and taking appropriate interventions on the identified factors play a greater role to prevent and control infection in the area. Further investigation is also needed to characterize the pathogens and risk factors and tackle the problem.
Reliability and validity of the East Asian children's version of mini-MACS in children with cerebral palsy
Authors: Hou Xiaohui , Qiu Huiying , Liu Liru , Li Yinhua , He Lu , Li Jinling , Tang Hongmei , Xu Kaishou
Published: November 2022

Background

Mini-Manual Ability Classification System (Mini-MACS) was developed for children with cerebral palsy aged 1–4 years, but its validity and reliability in different cultures are unavailable yet. This study was to determine the reliability and validity of Mini-MACS in East Asian children with cerebral palsy and investigate the correlation between Mini-MACS and Gross Motor Function Classification System.

Methods

One hundred and four East Asian children with cerebral palsy aged 12–48 months were classiﬁed by one of their parents, an occupational therapist, and a physical therapist with Mini-MACS. The results were analyzed for inter-rater reliability by using intraclass correlation coefficient (ICC). The Nine-hole Peg Test was used for the criterion-related validity analysis, and parents retested their children after 2 weeks to evaluate test–retest reliability. Gross Motor Function Classification System levels were also collected to investigate the correlation with Mini-MACS.

Results

Good inter-rater reliability among the occupational therapist, physical therapist, and parents was found [ICC = 0.984 (95% confidence interval, CI, 0.976–0.989), 0.973 (95% CI 0.960–0.982), and 0.966 (95% CI 0.950–0.977), respectively; p < 0.01]. The test–retest reliability in parents was almost perfect [ICC = 0.985 (95% CI 0.977–0.990), p < 0.01]. Mini-MACS had consistency with the Nine-hole Peg Test (r = 0.582, 0.581, and 0.566, respectively; p < 0.01). A correlation was found between Gross Motor Function Classification System and Mini-MACS (r = 0.626, 0.596, and 0.598, respectively; p < 0.01).

Conclusion

The Mini-MACS demonstrates evidence that it is a valid and reliable tool to classify manual ability in East Asian children with cerebral palsy and is also positively related to the Gross Motor Function Classification System.
Beneficial role of gut microbes in maintenance of pace-of-life traits in Phrynocephalus vlangalii
Authors: Bing Zhaohui , Niu Chenkai , Yang Cui , Qi Yue , Zhao Yangyang , Cao Shuhui , Zhao Wei
Published: November 2022

The pace-of-life syndrome theory suggests that species, populations, and individuals are positioned along a slow–fast pace-of-life continuum. However, whether and how individuals maintain a fast pace of life in a slow pace of life population remains unknown. In this study, the boldness and foraging behavior of Phrynocephalus vlangalii from Maduo (4250 m above sea level), a typical slow-paced population, were screened frequently. Both behaviors of P. vlangalii were significantly recurrent and linked with one another. Based on boldness and foraging behavior, the lizards were divided into positive and shy groups, and their gut microbial diversity were studied using 16S rRNA gene sequencing. No significant difference in α diversity was observed; however, a significant difference existed in the β diversity of gut microbes between the two groups. Principal coordinate analysis indicated that the gut microbes in the two groups were distinct. Linear discriminant analysis effect size determined that the shy group contained a more significant proportion of Rikenellaceae and Clostridia. In contrast, the positive group had a higher proportion of Verrucomicrobiota, Verrucomicrobiae, and Akkermansiaceae. Kyoto encyclopedia of genes and genomes pathway analysis revealed that biodegradation and metabolism, including lipid metabolism and glycan biosynthesis, were higher in the positive group; on the contrary, nucleotide metabolism and enzyme families were significantly higher in the shy group. The results showed that positive lizards had more beneficial intestinal microflora for lipid and glucose metabolism to satisfy their high metabolic energy demand, whereas shy lizards had more beneficial intestinal microflora for maintaining an elevated fasting blood glucose, a long life span, and a more stable metabolism to sustain their slow pace of life. In this study, we validate a strong relationship between the individual’s pace-of-life traits and intestinal microbiota in P. vlangalii. Further, we demonstrate that gut microorganisms are essential in sustaining the energy-intensive personality traits at high altitudes.