bluuebunny/crossref_metadata_2025 huggingface dataset:
DILEMA PENGATURAN KEDUDUKAN HUKUM INTERNASIONAL DI DALAM KONSTITUSI INDONESIA
Authors: Suwartono Rahadian Diffaul Barraq , Erlangga Vania Lutfi Safira
Published: June 2024

Abstract 
Indonesia faces a dilemma in its Constitution regarding the regulation of international law in relation to national law. Despite gaining independence over 78 years ago, there remains no unified stance on this issue. Indonesia actively participates in international relations and has adopted many international laws, creating a grey area that exacerbates legal issues. This article explores the Indonesian constitution’s challenges and shortcomings in regulating the position of international law, stemming from historical, sociological, and juridical factors. The primary issues are Indonesia’s inconsistent attitude towards international law and its indecisiveness in establishing a primary doctrine for its position, unable to decide between the monism and dualism theory. Nationalist groups, skeptical of international law, further complicate the situation by rejecting its inclusion in the Constitution. This confusion leads to derivative and latent problems within Indonesia’s legal system. The article examines why this dilemma exists and the resulting legal issues. The research is normative, employing conceptual, historical, and legal-policy approaches. It combines perspectives from Indonesian constitutional law and international law theories, prioritizing the Indonesian national interest paradigm.
Abstrak
Indonesia mengalami dilema untuk mengatur kedudukan hukum internasional terhadap hukum nasional di dalam konstitusi. Meski telah merdeka lebih dari 78 tahun yang lalu, Indonesia belum memiliki pandangan bulat dalam memosisikan hukum internasional. Hal ini membuka ruang abu-abu dan mengakibatkan efek domino yang memperkeruh permasalahan hukum di Indonesia. Artikel ini menyoroti dilema dan ‘kegagalan’ konstitusi Indonesia untuk mengatur posisi hukum internasional. Terdapat sumbangsih kegagalan penerapan teori hukum yang konsisten dalam munculnya dilema ini. Sikap fluktuatif Indonesia terhadap hukum internasional dan kebimbangan menentukan doktrin utama untuk memosisikan hukum internasional menjadi faktor paling dominan. Kebimbangan untuk menerapkan teori monisme atau dualisme menjadi akar masalah. Kondisi ini juga diperparah dengan adanya kelompok nationalist sentiment yang pesimistis terhadap hukum internasional dan menolak pengakuannya di dalam konstitusi. Kebimbangan ini mengakibatkan permasalahan turunan dan laten pada tata hukum di Indonesia. Artikel ini menjelaskan mengapa dilema ini terjadi dan apa saja permasalahan hukum yang diakibatkannya. Penelitian pada artikel ini disusun sebagai penelitian normatif yang menggunakan pendekatan konseptual, historis, dan politik hukum. Artikel ini menggabungkan perspektif hukum tata negaraIndonesia dengan perspektif teori hukum internasional dengan mengutamakan paradigma kepentingan nasional Indonesia.
ENVIRONMENTAL PERSONHOOD REIMAGINED: A CONCISE PHILOSOPHICAL REVIEW
Authors: Muhammad Pasha Nur Fauzan  , Indra Perwira  , Imamulhadi
Published: June 2024

Abstract
This paper is built upon one question: can the natural world be recognised as a ‘member’ of a legal community? By exploring the nature of legal personhood, this paper revisits the concept of environmental personhood. This paper uses the naturalistic approach to ground legal philosophical analysis in empirical realities and gain a deeper understanding of the natural world. This paper argues that legal personhood is an institutional fact influenced by moral ideas configured based on how humans organise organize value. The concept of ‘environmental personhood’ is built upon the idea that the natural world possesses inherent rights that must be protected similarly to human rights. This paper finds that, although the ecocentric approach to environmental personhood must be rejected, it can be salvaged. By reformulating environmental personhood based on artificial personhood, this paper opens up opportunities for the concept to be maintained. It aims to ground a theoretical foundation for further constitutional law research, specifically regarding how the constitution should frame the natural world’s ideal position within the state.
Abstrak
Penelitian ini didasarkan pada satu pertanyaan: dapatkah lingkungan dimasukkan sebagai anggota komunitas hukum? Dengan menelusuri konsep subjek hukum, penelitian ini meninjau kembali konsep lingkungan sebagai subjek hukum. Artikel ini menggunakan pendataan filsafat hukum naturalistik guna mendasarkan analisis filsafat hukum pada realitas empiris dan mampu menangkap pemahaman lebih dalam mengenai realitas alam. Artikel ini menemukan bahwa subjek hukum merupakan fakta institusional yang dibentuk oleh gagasan moral, yang dikonfigurasikan berdasarkan cara manusia mengorganisasikan nilai. Konsep lingkungan sebagai subjek hukum didasarkan pada gagasan bahwa alam memiliki hak inheren yang harus dilindungi. Artikel ini juga menemukan bahwa, meski pendekatan ekosentris dalam konstruksi lingkungan sebagai subjek hukum inkoheren dan mesti ditolak, konsep tersebut mungkin masih dapat diselamatkan. Penelitian ini diharapkan dapat menyediakan fondasi teoritis untuk penelitian Hukum Tata Negara lanjutan, utamanya mengenai bagaimana konstitusi harus mengonstruksikan posisi realitas alam dalam negara.
Susan Glaspell’s “Trifles”: A Feminist/Post-Structuralist Reading
Authors: Hussein Khalid M.
Published: June 2024

This study offers a feminist/post-structuralist reading of Susan Glaspell’s “Trifles”. It addresses man/woman binary opposition, not by taking the existence of one to mean the absence of the other, but in terms of looking at each side of the binary opposition as having a multiplicity of identifications that require various opposition models. In particular, it pays attention to the post/structuralist view of opposition as a societal construct that does not exist in objective reality, and therefore, could be challenged, dismantled and rectified. The study seeks to analyze Glaspell’s “Trifles” in the light of a quotation from Klages (2011) in which he uses the theatre seating arrangement as a metaphor for woman’s position in the male/female gender binary. Also, In “Trifles”, the patriarchal constructs underlying the judicial conventions have been confronted and the nature of criminality has been redefined when the women in the story repudiate the passivity foisted on them by engaging in a series of domestic feminine details that finally lead to the unraveling of the mystery of the crime. The study sheds light on the feminist rejection of patriarchy, and it concludes with the postulation that the time has come to incorporate the feminine perspective and female settings in the legal investigative tradition.
La Cucarachita Mondinga y el Ratón Pérez
Authors: Caballero Fernán
Published: June 2024

Para la Cucarachita Mondinga no es tarea fácil elegir con quién casarse. Aunque tiene pretendientes de sobra, los encantos de algunos de ellos no son suficientes para ganar su corazón. Un buen día Ratón Pérez pasa frente a la casa de la cucarachita y le pide su mano con tan linda voz, que ella lo acepta. Conoce el festejo de esta unión y descubre el descuido que pone en peligro la vida del buen ratón para susto de Mondinga, de sus amigas y de todos en el barrio. ¿Alguna vez has pensado qué leían las niñas y los niños de antes? ¿Cuáles eran sus historias? Biblioteca de Chapulín te transportará muchos años atrás. Conoce los cuentos que leían tus abuelas y abuelos a tu edad: historias que han estado vivas por mucho tiempo y que hoy llegan a tus manos por el valor del trabajo de escritores e ilustradores, artistas todos, que pensaron en ti aun sin conocerte. Cada uno de los libros de esta Biblioteca te llevará por diferentes caminos: visita países lejanos, como Rusia o China, descubre misteriosos objetos con poderes mágicos, aprende canciones nuevas y vive aventuras junto con ratones, gorriones y renacuajos fabulosos. ¡Anímate a conocerlos!
La pertinencia del Examen único de ingreso al bachillerato
Authors: Rivera Figueroa Antonio , Guerrero Magaña María de Lourdes , Sepúlveda López Armando , De Alaizola Arizmendi Iñaqui
Published: June 2024

Un examen de opción múltiple como el que elabora el CENEVAL, ¿es la mejor forma de hacer la selección de los estudiantes al bachillerato? Tratando de responder a esta y otras preguntas, en este artículo presentamos los resultados de un análisis que realizamos a los reactivos de las áreas de Matemáticas y Habilidades Matemáticas de la Guía de examen del año 2004, que sirve para preparar el EXANI-I y ha sido puesta a disposición del público general. Se reportan también los resultados obtenidos por diferentes grupos de estudiantes a los que fueron aplicados estos mismos reactivos. El análisis de estos resultados muestra que el EXANI-I puede estar discriminando a ciertos grupos de estudiantes, no por su falta de conocimiento matemático o limitada habilidad matemática, sino por otro tipo de factores, como lo es el diseño mismo de los reactivos.
The Recipe for the Perfect Sales Call
Authors: Shende Rushabh
Published: June 2024

Abstract: Sales calls are an essential part of any sales process as the beginning of the sales pipeline for any business. A sales call is an opportunity to connect with prospects, understand their needs and challenges, and offer solutions to help them achieve their goals. Salespeople need to make a good impression during the first sales call to ensure a strong start to the sale. This document offers the perfect recipe for a successful sales call. In this document, you will have detailed knowledge on how to make phone calls, how to deal with people, especially women, how people respond to your calls, and a new technique that I have created myself for making successful calls, and will help you not sound like a normal sales person call for your customer so you don't have to hold the phone. I took advantage of this and made over 50 successful calls out of 331 during my internship at a financial consulting firm. Objective: The main objective of this document is to help freshers make a successful sales call. This document contains some techniques that will help any beginner to make a sales call
Challenges with Medical Devices Connected To Hospital Network
Authors: Singh Jagbir
Published: June 2024

Abstract: The increasing adoption of connected healthcare technologies has transformed the traditional healthcare landscape, offering improved healthcare delivery. The combination of medical devices, sensors, and electronic health records has enabled real-time monitoring, remote care, and data-driven decision-making. However, the connectivity of medical devices to hospital network also introduces a vast array of challenges which include security challenges, scalability issues, and storage and interoperability issues. These challenges can compromise patient data, disrupt clinical workflows, and hinder the effective delivery of healthcare services. This article gives a detailed survey of the challenges and solutions in connected healthcare, with a focus on the technical and practical considerations of integrating medical devices into hospital networks. We explore the current state of connected healthcare, identify key challenges and limitations. Our analysis covers various aspects of connected healthcare, including device security, data privacy, network infrastructure, and standards for interoperability. Our paper also provides a comprehensive examination of the detailed architecture of connected healthcare system, encompassing different layers to facilitate a deeper understanding of connected healthcare system working. Finally, we explored the key research directions to handle the increasing challenges in connected healthcare system.
MySQL based Chit Chat Application
Authors: Gupta Ritik
Published: June 2024

Abstract: This project provides a modern chat application designed to work well with MySQL databases. The app uses Streamlit on the front end, providing a user interface through which users can query and manage data in natural language. The combination of OpenAI's GPT framework and LangChain provides powerful natural language processing and conversational capabilities, making data interaction more intuitive and efficient. This project demonstrates the integration of modern AI capabilities with traditional information management systems. The software bridges the gap between simple searches and user experience by providing a natural language interface to the database. This demonstrates the potential of AI to simplify data analysis and management tasks and make these powerful tools accessible to more people.
IMPACT OF FINANCIAL TECHNOLOGY (FINTECH) ON SHARIA BANKING: PERSPECTIVE OF FIQH ECONOMIC
Authors: Nisaa Mufida Auliyaun , Yazid Muhammad , Abdelmagid Eltayeb Salah Eltayeb
Published: June 2024

Penelitian dilakukan bertujuan agar para nasabah bank syariah bisa lebih yakin dan berhati-hati dalam menggunakan teknologi finansial dalam melakukan kegiatan di perbankan syariah. Penelitian ini bersifat penelitian kualitatif dengan metode penelitian literatur review yaitu metode peninjauan terhadap penelitian yang sudah dilakukan sebelumnya yang bersandar pada berbagai buku atau jurnal yang relevan. Dapat disimpulkan bahwa menurut perspektif fikih ekonomi teknologi finansial (fintech) yang digunakan dalam perbankan syariah merupakan bentuk adaptasi terhadap kemajuan teknologi dari waktu ke waktu. Karena terjadinya kemajuan teknologi membuat kebutuhan umat manusia juga mengalami kemajuan dan semakin beragam. Sehingga adanya teknologi finansial ini relevan dengan perspektif fikih ekonomi dalam hal mewujudkan kemaslahatan bagi umat manusia sesuai maqashid syariah. Nasabah tentu harus lebih paham tentang prinsip-prinsip syariah di bidang Fintech, termasuk rukun, akad, ketentuan, hukum, administrasi perpajakan, akuntansi, dan audit, agar terhindar dari riba dan gharar.
El cambio climático y la planificación urbano-territorial en Chile
Authors: Zazo-Moratalla Ana
Published: June 2024

At an international level, the first document to recognize climate change (CC) was the 1992 United Nations Framework Convention on Climate Change (UNFCCC). Its objective was to stabilize greenhouse gas (GHG) concentrations at a level that would prevent dangerous anthropogenic interference in the climate system. This implied preventing food production from being threatened and ensuring sustainable economic development. The Kyoto Protocol (1997) activated the UNFCCC by committing industrialized countries to limiting and keeping greenhouse gas emissions below committed individual targets. The imposed targets assumed an average reduction of 5% in emissions compared to 1990 levels over the 2008-2012 five-year period. Today, the international community is governed by the legally binding Paris Agreement (2015), which aims to limit global warming to 1.5°C above pre-industrial levels. In 2020, all the signatory countries, including Chile, presented their climate action plans, known as Nationally Determined Contributions (NDCs).
Economia criativa e o comer em modos slow e comfort food: movimentos de resistência na cidade
Authors: Barcellos Daniela , Menezes Neiva Barcellos Daniela , Fernandes dos Reis Lesly , Albuquerque Borges Quaresma GONÇALVES Victor
Published: June 2024

A cidade é intrinsecamente dinâmica, ampliando-se por meio de interconexões, reorganizações,desempenhos e padrões de consumo. A cidade não apenas existe, mas, acima de tudo, propor-ciona experiências que amalgamam subjetividades e realidades objetivas. No contexto urbano,são vivenciadas intensas ressignificações. Pode-se perceber o trânsito entre fluxos de sentido defenômenos comunicacionais como o da comensalidade, do comer junto. Alimentação e afetosestão imbricados na cidade. Partindo dessas observações, o objetivo deste trabalho é, com o olhara partir da economia criativa, lançar luz sobre as possíveis dissonâncias entre as ofertas do comerque se apresentam na cidade em modosslowecomfort foode a legítima busca de consumidoresde um nicho politizado e engajado em pautas socioambientais e anticapitalistas. Essas temáticasse manifestam como movimentos de resistência no contexto urbano que envolve uma socieda-de acelerada e produtivista. Essas buscas sobressaíram na cidade em tempo de pandemia e derupturas, notadamente na internet. Propomos também uma reflexão sobre como o mercado seapropria dessas pautas que geram engajamento para promover o seu produto ou serviço, porémmuitas vezes não sustenta sua proposta, uma vez que podem não promover percepção de valoraos que consomem. O trabalho se inscreve em uma abordagem qualitativa, sob um olhar socioan-tropológico, em postagens nas redes sociais e publicações online. Fez-se uma busca por temáticasrelacionadas aocomfort fooddurante o período da pandemia de COVID-19.
Editorial
Authors: Robaina Diogo Tavares
Published: June 2024

Editorial v.9 n25.
Entre a Educação de Adultos, a Educação Popular e a EJA
Authors: Martins Francisco André Silva , Alves Rafaelle Stefane Elias , Pinto Gláucia Moreira
Published: June 2024

O presente trabalho tem como foco uma discussão que agrega os elementos da Educação de Adultos em relação direta com a Educação Popular e a Educação de Jovens e Adultos no decorrer da história do Brasil. Foi feita uma retomada de experiências de educação de adultos, em vários períodos históricos, com o intuito de melhor delimitar essas fronteiras. Isso com o propósito de contribuir para adensar as reflexões produzidas na área, bem como apontar as singularidades, as aproximações e os distanciamentos de cada experiência abordada. Em diálogo com produções de pesquisadores da referida temática, buscamos correlacionar elementos da teoria e da prática com o intuito contribuir para o avanço dos debates. Ao final, foram abordados elementos da Educação de Jovens e Adultos na atual conjuntura social do país e seus obstáculos e potencialidades.
Editorial: Recent trends in corporate governance and sustainability.
Authors: De Gárate Pérez Luis Eugenio
Published: June 2024

This issue of the Corporate Governance and Sustainable Review summarizes the recent trends in corporate governance and sustainability reflected in our featured articles. These studies offer critical insights into the evolving landscape of mergers and acquisitions, International Financial Reporting Standards (IFRS), sustainable fashion practices, and public procurement bid disputes emphasizing the importance of robust corporate governance mechanisms and sustainability initiatives.
Corporate governance and board conflict solution: The case of Lebanese family healthcare businesses
Authors: Shatila Khodor , Nigam Nirjhar , Benetti Cristiane
Published: June 2024

This study examines the intricate relationship between corporate governance mechanisms and the performance of family-owned hospitals in Lebanon. Specifically, it examined the impact of various governance factors, including board size, independence, duality, meeting frequency, and ownership structure, on the financial performance of these hospitals. By employing agency theory as the conceptual framework and qualitative methodology, which involves interviews with managers from three distinct hospitals in Lebanon, this study sheds light on the dynamics of conflicts between shareholders and managers within the context of family-owned hospitals. This study also explores how corporate governance mechanisms can effectively mitigate these conflicts and enhance shareholder value. The significance of this study lies in its contribution to the understanding of corporate governance practices within the Lebanese healthcare sector, offering valuable insights that extend to developing countries across the Middle East and North Africa (MENA) region. These findings suggest that fostering a more autonomous board structure can play a pivotal role in controlling top management and aligning the interests of shareholders and managers within the Lebanese healthcare landscape. Through a nuanced exploration of governance dynamics and their implications for financial performance, this study underscores the importance of robust governance frameworks for ensuring the sustainable success of family-owned hospitals. Ultimately, by elucidating the mechanisms by which governance practices influence organizational outcomes, this study offers practical implications for healthcare practitioners, policymakers, and stakeholders seeking to enhance governance effectiveness and performance in similar contexts.
Dupilumab improves symptoms and reduces rescue treatments in patients with CRSwNP and recalcitrant frontal sinusitis
Authors: Corso Eugenio De , Settimi Stefano , Penazzi Daniele , D'Agostino Giuseppe , Montuori Claudio , Corbò Marco , Spanu Camilla , Rizzzuti Alberta , Pacilli Maria Clara , Rigante Mario , Rizzi Angela , Chini Raffaella , Galli Jacopo
Published: June 2024

Background. Recalcitrant frontal sinusitis in patients with
chronic rhinosinusitis with nasal polyps (CRSwNP) have a negative impact
on quality of life due to frontal pain and a high risk of sinus
occlusion, thus necessitating repeated courses of antibiotics, systemic
corticosteroids, and multiple surgeries. Objective. The aim of
this study was to investigate if the use of biologics can improve
symptoms including facial pain and reduce use of rescue treatments in
patients with severe uncontrolled CRSwNP and concomitant recurrent
frontal sinusitis. Materials and Methods. This is a real-life,
observational, no-profit case series. Between November 2022 and December
2023, we enrolled cohort of 10 patients with severe uncontrolled CRSwNP
and concomitant recurrent frontal sinusitis associated to invalidating
facial pain measured by MIDAS score and that were treated with dupilumab
300 mg every 2 week and followed for at least 12 months.
Results. the mean MIDAS score decreased from 45.6±10.7 at
baseline to 1.3±2.3 at 6 months (p<0.05). The same trend was
observed for VAS craniofacial pain: from 7.3±1.6 at baseline to 1.2±1.5
at 6 months (p<0.05). The use of systemic corticosteroids and
analgesics was significantly reduced. No patient needed oral
corticosteroids during treatment with dupilumab (p<0.05), and
the use of analgesics decreased from 9.6±3.1 mean brief cycles of NSAIDs
at baseline to 0.6±1.3 at 1 year of follow-up (p<0.05).
Discussion. Our results demonstrated that use of an anti-type-2
inflammatory pathway biologic can improve symptom control including
recurrent craniofacial pain and reduce the need for rescue medical
treatments in patients with severe uncontrolled CRSwNP and concomitant
recurrent frontal sinusitis.
Side effect of insecticides against some beneficial species
Authors:   Trakia University, 6000 Stara Zagora, Bulgaria, Mineva Roksana , Yankova Vinelina ,   Maritsa Vegetable Crops Research Institute, Agricultural Academy, 4003 Plovdiv, Bulgaria, Valchev Nikolay ,   Trakia University, 6000 Stara Zagora, Bulgaria
Published: June 2024

Beneficial species of predators and parasitoids play an important role in sustainable pest control. Toxicity evaluation of insecticides against the natural enemies of the pests is very important in the selection of a product intended for application within the Integrated Pest Management (IPM). The effectiveness of beneficial species as biological control agents may be compromised by side effects caused by insecticides. Tests were conducted under laboratory conditions to determine the toxicity of 18 insecticides against the beneficial species Encarsia formosa Gahan, Macrolophus pygmaeus Rambur and Amblyseius cucumeris Oudeman. Plant protection products Rapax (i.e. Bacillus thuringiensis subsp. kurstaki strain EG 2348) 0.1%, Dipel 2X (i.e. Bacillus thuringiensis var. kurstaki strain ABTS) 0.1%, Naturalis (i.e. Beauveria bassiana strain ATCC 74040) 0.1%–0.15%, Helicovex (i.e. Helicoverpa armigera nucleopolyhedro virus Hear NVP, DSMZ–BV0003) 0.02%, Neem Azal T/S (i.e. azadirachtin) 0.3% and Limocide (i.e. orange oil) 0.4% were slightly toxic (toxicity up to 37%) to the tested bioagents. They can be successfully applied in integrated plant protection systems. Toxic to highly toxic were the following insecticides: Koragen 20 SC 0.02%, Voliam Targo 063 SK 0.08%, Ampligo 150 ZK 0.04%, Closer 120 SC 0.04%, Confidor Energy OD 0.08%, Vaztak new 100 EC 0.03%. These insecticides should be avoided when introducing bioagents into greenhouses. Keywords: Encarsiaformosa, Macrolophuspygmaeus, Amblyseius cucumeris, toxicity, plant protection products
Analysis of the state of the surface waters of the Pyasachnik dam
Authors:   East Aegean River Basin Directorate, Plovdiv, Bulgaria, Iliev Ivaylo
Published: June 2024

An ecological monitoring survey of the freshwater ecosystem of the Pyasachnik Dam was carried out in the period 2011-2016. The main indicators of surface water quality such as temperature, transparency, electrical conductivity, dissolved oxygen, N–NH4, N–NO2, N–NO3, orthophosphates P, total nitrogen, total phosphorus, and chlorophyll a content were monitored. Hereafter, the obtained results are discussed by years and seasons. The chemical status and ecological potential of the freshwater ecosystem were determined. The investigated surface waters are suitable for irrigation, but with a permanent mandatory monitoring. Keywords: ecological potential, irrigation, physicochemical monitoring, chemical status, chlorophyll
Sucking insect’s pest management in organic rose production
Authors:   Agricultural University-Plovdiv, Bulgaria, Georgieva Rumyana , Manolov Ivan ,   Agricultural University-Plovdiv, Bulgaria, Manhart Svetlana ,   Agricultural University – Plovdiv, Bulgaria, Steinkellner Siegrid ,   University of Natural Resources and Life Sciences, Vienna, Austria, Möth Stefan ,   University of Natural Resources and Life Sciences, Vienna, Austria
Published: June 2024

Sucking insects are the most common pests and could affect a wide range of cultural and wild plants. They possess a big reproductive potential and under favourable climatic conditions can cause considerable damages on agricultural crops. Some of the sucking insects show resistance to chemical pesticides, which additionally makes their control difficult. To investigate the effect of natural pesticides on the population of some sucking insects in a two year`s field experiment was conducted in the region of the village Kliment on five years`s old organic rose plantation. The following products have been included in the investigation: Limocide® (60 g/L orange oil) NeemAzal® T/S (Nime-substance – 2.5 %) and 4 % bee glue solution. The field experiments were arranged according to the block method in four replications and plot size of 18 м2 (21 plants per variant). The population density of sucking insects varied depending on the climate conditions. The product Limocide® and the 4% bee glue solution managed to control the invasion of the two-spotted spider mite Macrosiphum rosae L. and proved their effectiveness against Thrips tabaci as well. The product that contain as azadirachtin as an active substance showed an unsatisfactory percentage of effectiveness against the target insects. The 4% bee glue solution has a great potential, and its mechanism of action needs to be further investigated. Keywords: biological control, sucking insects, roses
Epoxygenase Cyp2c44 regulates hepatic lipid metabolism and insulin signaling by controlling FATP2 localization and activation of the DAG/PKCδ axis
Authors: Ghoshal Kakali , M. Luther James , B. Pakala Suman , Chetyrkin Sergei , R. Falck John , Zent Roy , H. Wasserman David , Pozzi Ambra
Published: June 2024

Cytochrome P450 epoxygenase Cyp2c44, a murine epoxyeicosatrienoic acid (EET) producing enzyme, promotes insulin sensitivity and Cyp2c44(-/-) mice show hepatic insulin resistance. Because insulin resistance leads to hepatic lipid accumulation and hyperlipidemia, we hypothesized that Cyp2c44 regulates hepatic lipid metabolism. Standard chow diet (SD) fed male Cyp2c44(-/-) mice had significantly decreased EET levels and increased hepatic and plasma lipid levels compared to wild-type mice. We showed increased hepatic plasma membrane localization of the FA transporter 2 (FATP2) and total unsaturated fatty acids and diacylglycerol levels. Cyp2c44(-/-) mice had impaired glucose tolerance and increased hepatic plasma membrane-associated PKCδ and phosphorylated IRS-1, two negative regulators of insulin signaling. Surprisingly, SD and high fat diet fed (HFD) Cyp2c44(-/-) mice had similar glucose tolerance and hepatic plasma membrane PKCδ levels, suggesting that SD-fed Cyp2c44(-/-) mice have reached their maximal glucose intolerance. Inhibition of PKCδ resulted in decreased IRS-1 serine phosphorylation and improved insulin-mediated signaling in Cyp2c44(-/-) hepatocytes. Finally, Cyp2c44(-/-) HFD-fed mice treated with the analog EET-A showed decreased hepatic plasma membrane FATP2 and PCKDd levels with improved glucose tolerance and insulin signaling. In conclusion, loss of Cyp2c44 with concomitant decreased EET levels leads to increased hepatic FATP2 plasma membrane localization, diacylglycerol accumulation, and PKCδ-mediated attenuation of insulin signaling. Thus, Cyp2c44 acts as a regulator of lipid metabolism by linking it to insulin signaling.
Neonatal amino acids and acylcarnitines associated with maternal blood glucose levels throughout pregnancy: Insights from the Beijing Birth Cohort Study
Authors: Zheng Wei , Yuan Xianxian , Zhao Jinqi , Han Weiling , Huang Junhua , Yan Xin , Zhang Lirui , Li Lulu , Wang Shunan , Kong Yuanyuan , Li Guanghui
Published: June 2024

Objective: To determine the association between maternal blood glucose patterns throughout pregnancy and neonatal amino acids and acylcarnitines.

Research Design and Methods: We conducted a prospective cohort study involving 11,457 singleton pregnant women without pre-existing diabetes from the Beijing Birth Cohort Study, along with their neonates born between July 2021 and October 2022 in Beijing, China. Distinct maternal glucose trajectories were identified using a latent class model based on blood glucose levels across the three trimesters, and their association with neonatal circulating metabolites, including 11 amino acids and 33 acylcarnitines, was examined, adjusting for potential confounding factors.

Results: Three distinct groups of maternal glucose trajectories were identified: consistent normoglycemia (n = 8,648), mid-to-late gestational hyperglycemia (n = 2,540), and early-onset hyperglycemia (n = 269). Mid-to-late gestational hyperglycemia was associated with decreased levels of amino acids (alanine, arginine, ornithine, and proline) involved in the arginine and proline metabolism, and urea cycle pathway, as well as increased levels of C4DC+C5-OH, and decreased level of C6DC and C10:1. Early-onset hyperglycemia was associated with elevated levels of free acylcarnitine and C4DC+C5-OH and decreased level of C10:1, involved in the fatty acid oxidation pathway. However, these associations were primarily observed in male neonates rather than in female neonates.

Conclusions: Our findings revealed a significant link between maternal glucose trajectories throughout pregnancy and neonatal arginine and proline metabolism, urea cycle pathway, and fatty acid oxidation pathway. These results highlight the importance of maintaining optimal blood glucose levels throughout pregnancy to promote healthy neonatal metabolic outcomes.
Determinants of Diabetes Awareness among Hispanics/Latino adults in the US, 2005-2018
Authors: Niño de Rivera Jessica , S. Albrecht Sandra
Published: June 2024

Objective: Despite improvements in screening, Hispanics/Latinos bear a disproportionate burden of undiagnosed diabetes in the US. Identifying who is at risk within this large and diverse population is important for targeting interventions. In this study, we sought to characterize risk factors for undiagnosed diabetes among Hispanics/Latinos. We also investigated determinants among insured adults to explore barriers for those with access to care.

Research Design and Methods: We used data among 1,883 Hispanic/Latino adults aged > 20 years from the National Health and Nutrition Examination Surveys (2005-2018). Sequential multivariable logistic regression models examined a range of social, healthcare, and individual-level determinants of undiagnosed diabetes (defined as having elevated fasting plasma glucose > 126 mg/dl or HbA1c > 6.5% (48 mmol/mol) in participants self-reporting not having diabetes) in the overall sample, and among those with health insurance (n=1401).

 Results: Younger age (20-44 years old), male sex, and immigrants (compared to the US-born), but not socioeconomic factors, were significantly associated with higher odds of undiagnosed diabetes compared to being diagnosed. These estimates were attenuated after adjusting for healthcare utilization variables. In fully adjusted models, having no healthcare visits in the past year, reporting no family history of diabetes, and better self-reported health were the predominant risk factors for undiagnosed diabetes in the overall sample, and also among insured Hispanic/Latino adults.

Conclusions: Our findings highlight the importance of reaching younger, male, and immigrant Hispanic/Latino adults, as well as addressing barriers to healthcare utilization, even among insured adults, to improve diabetes awareness.
Topical Minoxidil Rejuvenates Hair Follicles from Men with Androgenetic Alopecia in Vivo
Authors: Zeltzer Assaf A. , Keren Aviad , Paus Ralf , Gilhar Amos
Published: June 2024

Abstract is missing (Short communication)
The Impact of Atopic Dermatitis on Sexual Function and Reproductive Desires in Women
Authors: Rodríguez-Pozo Juan-Angel , Montero-Vílchez Trinidad , Diaz Calvillo Pablo , Sanabria de la Torre Raquel , Ureña Paniego Clara , Ramirez-Muñoz Arena , Arias Santiago Salvador
Published: June 2024

Atopic dermatitis is a prevalent skin condition that affects up to 17% of adult population. It can lead to itching, pain, and other symptoms such as sleep disturbance, anxiety, and depression. Due to its high prevalence and limiting symptoms, atopic dermatitis often has a great impact on patients’ quality of life but there is scarce information regarding how atopic dermatitis affects women’s sexual health and reproductive desires. The purpose of this article was to assess the impact of atopic dermatitis on sexual function and reproductive wishes in women. A cross-sectional study was conducted from February to March 2022. A total of 102 women with atopic dermatitis were recruited through online questionnaires sent through the Spanish Atopic Dermatitis Association; 68.6% of the patients acknowledged impairment in sexual function, especially those with more severe disease and those with genital and gluteal involvement. In addition, 51% of the women considered that atopic dermatitis may have an influence on their gestational desire, particularly those with gluteal involvement. In conclusion, atopic dermatitis has a great impact on sexual function and reproductive desires in women.
The association of empathy and the work–family conflict in doctors of dental medicine
Authors: Gavic Lidia , Jerkovic Antonija , Ambarkova Vesna , Jerkovic Daniel , Tadin Antonija
Published: June 2024

Objectives: Work–family conflict is a growing problem worldwide, because of changing work–family demographic trends and the spread of technology. Empathy, as the ability to understand and share the feelings of other people, is the essential component of emotional intelligence that plays a crucial role in healthcare settings. This study aimed to assess the level of emotional empathy and investigate its relationship with work–family role conflicts among dental medicine doctors. 
Materials and methods: In this study participated 589 doctors of dental medicine from Croatia, Serbia, Bosnia and Herzegovina. The questionnaire included general and demographic data, the Emotional Empathy Scale questionnaire and the Work and Family Role Conflict Assessment Scale questionnaire. 
Results: The research results indicate no significant association between empathy and conflict between work and family roles (R = 0.032, p = 0.435). Women have achieved significantly higher scores in Emotional Empathy Scale (p ≤ 0.001), while there was no difference in Work and Family Role Conflict Assessment Scale according to gender (p = 0.194). A difference in emotional empathy was observed depending on where the respondents were employed (p = 0.045) and depending on the specialisation of the dental medicine (p = 0.021). 
Conclusion: Female doctors of dental medicine demonstrated higher emotional empathy while the work–family role conflict is experienced equally by both genders.
Funciones jurisdiccionales de las autoridades indígenas del Pueblo Palta: Perspectiva histórica y actual
Authors:   Investigador Independiente, Jimbo Sáez Isabel De Fátima , Maldonado Ruiz Luis Mauricio ,   Investigador Independiente
Published: June 2024

El estudio analiza el poder y gobierno indígena en Ecuador, enfocado en la normativa constitucional y el derecho consuetudinario. Mediante una revisión de la Constitución de 2008 y sentencias de la Corte Constitucional, se examina cómo las autoridades indígenas ejercen funciones jurisdiccionales basadas en sus tradiciones, costumbres y el derecho propio. Se concluye que la Constitución y el Código Orgánico de la Función Judicial reconocen la jurisdicción indígena dentro de su ámbito territorial, garantizando los derechos humanos y constitucionales. La Corte Constitucional establece criterios para delimitar la competencia de la justicia indígena, destacando la importancia de la autonomía y autodeterminación de las comunidades. El estudio concluye que los derechos colectivos y el derecho consuetudinario son esenciales para un verdadero Estado de Derechos Plurinacional e Intercultural, y que la autodeterminación y el respeto a la justicia indígena son esenciales para preservar la identidad y promover la convivencia armoniosa dentro de las comunidades indígenas y con el Estado. Además, se resalta la necesidad de garantizar la autonomía de las comunidades para gestionar sus propios asuntos sin interferencia externa.
Estrategias Digitales para la Difusión del Patrimonio Cultural en la Comuna Ligüiqui: Un Enfoque en Herramientas Comunicacionales
Authors:   Investigador Independiente, Cadena Bermúdez María Fernanda , Baquero Arévalo Hernán Omar ,   Investigador Independiente
Published: June 2024

Este artículo examina los estándares de investigación judicial aplicados en casos de graves violaciones a los derechos humanos en Ecuador. A través de un enfoque cualitativo que combina el análisis documental de casos emblemáticos y entrevistas con expertos en derechos humanos y profesionales del ámbito judicial, se evalúa la efectividad de las prácticas actuales y se identifican las principales barreras y desafíos. Los resultados revelan inconsistencias en la aplicación práctica de los estándares, destacando la necesidad de fortalecer la independencia judicial, mejorar la capacitación de los operadores de justicia y asegurar recursos adecuados para una investigación efectiva. Las conclusiones sugieren la urgencia de reformas integrales en el sistema judicial ecuatoriano para garantizar una administración de justicia justa y eficaz en casos de derechos humanos. Este estudio proporciona una base sólida para futuras investigaciones y ofrece recomendaciones concretas para mejorar la implementación de los estándares de investigación judicial, con implicaciones significativas para la comunidad científica y la sociedad en general en términos de protección y promoción de los derechos humanos en Ecuador.
Desarrollo de sistemas de IA autónomos: avances, desafíos y consideraciones éticas
Authors:   Investigador Independiente, Zambrano Salazar Luis Leonardo , Gamboa López Enma Katherine ,   Investigador Independiente, Pico Núñez María Fernanda ,   Investigador Independiente
Published: June 2024

Este artículo examina el desarrollo de sistemas autónomos de Inteligencia Artificial (IA) en Ecuador, identificando avances, desafíos y consideraciones éticas. A través de una revisión documental y encuestas a expertos en IA de tres universidades ecuatorianas, se proporciona una visión integral del estado actual de la IA autónoma en el país. Se destacan los avances en áreas como aprendizaje profundo, robótica y sensores, y se identifican desafíos clave relacionados con la infraestructura tecnológica, la disponibilidad de datos de calidad y la formación en IA. Se discuten las consideraciones éticas, incluyendo la seguridad, la transparencia y la protección de los derechos individuales. Los expertos enfatizan la necesidad de colaboración intersectorial y un enfoque ético para el desarrollo de la IA. El estudio concluye que, a pesar de los desafíos, existen oportunidades significativas para el desarrollo de la IA autónoma en Ecuador.
El Impacto transformador de las Tecnologías de la Información y Comunicación (TIC) en estudiantes con necesidades educativas
Authors:   Investigador Independiente, Cagua Llulluna Estefany Jazmín , Lozada Calderón Ligia Patricia ,   Investigador Independiente, Paucar Caiza Nelly Maribel ,   Investigador Independiente, Ponce Rosero Michael Estuardo ,   Investigador Independiente
Published: June 2024

Este artículo profundiza en los desafíos fundamentales que enfrentan las Tecnologías de la Información y la Comunicación (TIC) y ofrece una perspectiva exhaustiva sobre cómo estas tecnologías influencian y moldean el panorama educativo actual y futuro. Inicia con la definición y contextualización de la sociedad del conocimiento en la era contemporánea, subrayando cómo su evolución, especialmente impulsada por los avances tecnológicos, ha dejado una marca significativa en diversos sectores, entre ellos la educación. Se explora detalladamente cómo este desarrollo tecnológico ha provocado cambios profundos en la forma en que se enseña y se aprende, estimulando la creación de nuevos enfoques pedagógicos y estrategias innovadoras para fortalecer el proceso de enseñanza – aprendizaje de los estudiantes con necesidades educativas. Se hace hincapié en cómo las TIC han sido catalizadoras de la innovación educativa, proporcionando herramientas y plataformas que facilitan el acceso a la información, promueven la colaboración entre estudiantes con necesidades educativas y docentes, y potencian la creatividad y el pensamiento crítico. Además, se analiza en profundidad el papel crucial de cada actor dentro del entorno educativo, desde los docentes hasta los estudiantes, destacando su capacidad para transformar el proceso de enseñanza-aprendizaje mediante el aprovechamiento efectivo de las tecnologías disponibles.
Identity Building through a Sense of Injustice for Housing Estate Kids Historical Transmission, Segregation Processes and Radical Stances
Authors: E* Marlière
Published: June 2024

Made up for the most part of children of blue-collar workers and immigrants, the youth of French housing estates is yet denied the social organization of the labor community. The legacy of its working-class past is all the more heavy to carry that its present is as uneasy and uncertain as ever. This is why these young people have developed, over two generations, a way of life that is partly specific to them, from creating their own “street culture” to practicing Islam with varying degrees of assiduity, to starting a career in petty crimes – the latter aiming to counteract unemployment and general precariousness. While most are not delinquents, they are faced, as the “inheritors of the working-class neighborhoods,” with economic hardship and discrimination, making them the scapegoats of a country that yet is a democracy. That is why within less than 30 years, as a response to both social frustration and the contempt shown by elites and administrative institutions alike, a sense of collective injustice permeates the youth-and those who are now adults-in these neighborhoods.
Understanding moderators of consent regarding the sharing of supermarket shopping data in ALSPAC.
Authors: Burgess Romana , Skatova Anya , Taylor Poppy
Published: June 2024

Introduction & BackgroundShopping data is a valuable resource, offering insights into consumer behaviour and health. In recent years, there has been a growing interest in using shopping data for the purposes of health research. However, little is known about the characteristics of those who are willing to share their shopping data with researchers.
Objectives & ApproachThis study aims to investigate the factors that influence individuals' decisions to consent to sharing their shopping data for research purposes. We will leverage data from a cohort study – the Avon Longitudinal Study of Parents and Children (ALSPAC) – to address this question.
We will draw upon the responses of a 2018 survey, which asked ALSPAC participants about their use of supermarket loyalty cards, their perceived acceptability of sharing this data with ALSPAC, and their perspectives on potential privacy concerns. Of the 4,462 respondents, 65.4% indicated ownership of at least one major UK supermarket or store loyalty card. Among these, 88.4% expressed a potential willingness to share this data with ALSPAC for research purposes. In the present day – around 2023 – participants have explicitly either granted or withheld consent for the sharing of this data.
Our analysis approach will consider factors such as biological gender, ethnicity, education, employment, socioeconomic status, and anxiety as potential moderators to the consent process. We plan to employ a mix of standard statistical methods to analyse sampling biases in the dataset, including regression modelling and correlation tests.
Relevance to Digital FootprintsOur study will contribute to the growing body of literature on data linkage between cohort studies and digital footprints datasets.
ResultsThe findings from this study will offer valuable insights into the factors influencing participants' consent decisions regarding data sharing. We will contribute to ongoing discussions about privacy and the ethical use of digital footprints data, informing the development of more inclusive consent processes in this field.
Conclusions & ImplicationsThis study will inform consent practices in the realm of digital footprints, identifying and addressing potential barriers to consent, and contributing to the ongoing discourse on the responsible and ethical use of shopping data.