bluuebunny/crossref_metadata_2025 huggingface dataset:
Relationship between hypercholesterolemia and osteoarthritis (preliminary results)
Authors: Taskina Elena A. , Alekseeva Liudmila I. , Kashevarova Natalia G. , Strebkova Ekaterina A. , Mikhaylov Kirill M. , Sharapova Evgeniia P. , Savushkina Natalya M. , Alekseeva Olga G. , Raskina Tatiana A. , Averkieva Julia V. , Usova Ekaterina V. , Vinogradova Irina B. , Salnikova Oksana V. , Markelova Aleksandra S. , Lila Aleksander M.
Published: June 2024

Aim. To evaluate the relationship of hypercholesterolemia (HCE) with clinical, instrumental, and laboratory parameters in osteoarthritis (OA) in a multicenter, cross-sectional study.
Materials and methods. The study included 183 patients aged 40–75 years, with a confirmed diagnosis of stage I–III OA (ACR) of the knee joints, who signed an informed consent. The mean age was 55.6±10.7 years (40 to 75), body mass index was 29.3±6.3 kg/m2, and disease duration was 5 [1; 10] years. For each patient, a case record form was filled out, including anthropometric indicators, medical history, clinical examination data, an assessment of knee joint pain according to VAS, WOMAC, KOOS and comorbidities. All patients underwent standard radiography and ultrasound examination of the knee joints and laboratory tests.
Results. HCE was detected in 59% of patients. Depending on its presence or absence, patients were divided into two groups. Patients were comparable in body mass index, waist and hip measurement, and disease duration but differed significantly in age. Individuals with elevated total cholesterol levels had higher VAS pain scores, total WOMAC and its components, an overall assessment of the patient's health, a worse KOOS index, and ultrasound findings (reduced cartilage tissue). HCE patients showed high levels of cholesterol, low-density lipoproteins, triglycerides, STX-II, and COMP (p0.05). However, after stratification by age, many initial intergroup differences became insignificant, and differences in the WOMAC pain score persisted.
Conclusion. The results of the study confirmed the high prevalence of HCE in OA patients (59%). Patients with OA and increased total cholesterol have more intense pain in the knee joints.
Chronic hepatitis B in rheumatic diseases: issues of screening and reactivation of infection: A review
Authors: Gridneva Galina I. , Belov Boris S. , Aronova Evgeniia S.
Published: June 2024

Patients with rheumatic diseases infected with hepatitis B virus (HBV) are difficult to manage not only due to the presence of risk factors for the development and rapid progression of liver cirrhosis, but also due to the likelihood of reactivation of this infection. Despite the successes achieved in the fight against HBV, the virus cannot be completely defeated due to the presence of hidden forms of the disease, escaping the field of vision of a rheumatologist and an infectionist. Based on the results of the analysis of current publications, the paper presents the rationale for a complete immunological screening of patients with rheumatic diseases when prescribing antirheumatic therapy. The issues of the role of COVID-19 in the exacerbation of chronic viral hepatitis B, antiviral prevention and monitoring are discussed, the classification of antirheumatic drugs according to the risk of HBV reactivation is presented.
Results of a randomized double-blind multicenter clinical trial of the efficacy and safety of riamilovir in the treatment of COVID-19
Authors: Sabitov Alebai U. , Lioznov Dmitry A. , Zhdanov Konstantin V. , Tikhonova Elena P. , Esaulenko Elena V. , Kovtun Olga P. , Kuznetsov Pavel L. , Sorokin Pavel V.
Published: June 2024

Aim. To evaluate the efficacy and safety of riamilovir in the treatment of COVID-19 in adults.
Materials and methods. The study included 180 patients with a laboratory-confirmed diagnosis of COVID-19 which fully meet the criteria for inclusion, non-inclusion and exclusion, signed a voluntary informed consent to participate in a clinical trial.
Results. The efficacy, good tolerability and safety of the drug riamilovir in the treatment of COVID-19 have been established.
Conclusion. As a result of a multicenter randomized double-blind clinical trial, the effectiveness of the drug riamilovir for therapeutic use in patients with COVID-19 according to the 1250 mg/day scheme (250 mg capsules 5 times per day) for 10 days was established. The drug riamilovir in a daily dose of 1250 mg for 10 days does not differ in safety from placebo.
Current treatment for spondyloarthritis: focus on netakimab. A review
Authors: Karateev Dmitry E. , Luchikhina Elena L.
Published: June 2024

Spondyloarthritis (SpA) is a group of rheumatic diseases that includes ankylosing spondylitis (AS), psoriatic arthritis (PsA) and a number of other diseases. SpA lead to a significant social problem, since it is a common pathology that debuts mainly at a young age, significantly impairing the ability to work and the ability to social contacts of the most active part of the population. For all the main types of chronic progressive SpA, biological agents (biologics) are of great importance in patients with persistent activity despite standard treatment, especially in the case of predominantly axial involvement, since in this case it is actually the only option for effective treatment, in addition to the constant use of non-steroidal anti-inflammatory drugs (NSAIDs). Over the past decade, interleukin-17A (IL-17A) inhibitors have taken the first place in therapy of SpA, because, according to modern ideas about pathogenesis, IL-17A may be a key target for therapeutic intervention in SpA. In terms of ensuring availability for Russian patients with SpA, it is of particular importance to the introduction of the original medication from the group of IL-17A inhibitors Netakimab (NTK). This review presents data from randomized clinical trials of NTK phases I, II and III in AS and PsA also post-registration observational studies of phase IV, including analysis of subpopulations of patients of special interest, in particular, patients with psoriatic spondylitis. NTK demonstrated high effectiveness in the treatment of SpA both in randomized clinical trials and in clinical practice. The drug is characterized by a rapid onset of clinical action and persistent maintenance of the achieved improvement, a complex effect on various manifestations of the disease, is able to have a structure-modifying effect and slow down the progression of both the erosive process and osteoproliferation. The safety profile of NTK is generally typical for the entire group of IL-17 inhibitors. The drug has low immunogenicity, which allows us to count on the possibility of many years of effective use. Resolutions of expert councils on the use of NTK in AS and PsA support the inclusion of this drug in clinical guidelines.
The importance of DNA sequence for nucleosome positioning in transcriptional regulation
Authors: Sahrhage Malte , Paul Niels Benjamin , Beißbarth Tim , Haubrock Martin
Published: June 2024

Nucleosome positioning is a key factor for transcriptional regulation. Nucleosomes regulate the dynamic accessibility of chromatin and interact with the transcription machinery at every stage. Influences to steer nucleosome positioning are diverse, and the according importance of the DNA sequence in contrast to active chromatin remodeling has been the subject of long discussion. In this study, we evaluate the functional role of DNA sequence for all major elements along the process of transcription. We developed a random forest classifier based on local DNA structure that assesses the sequence-intrinsic support for nucleosome positioning. On this basis, we created a simple data resource that we applied genome-wide to the human genome. In our comprehensive analysis, we found a special role of DNA in mediating the competition of nucleosomes with cis-regulatory elements, in enabling steady transcription, for positioning of stable nucleosomes in exons, and for repelling nucleosomes during transcription termination. In contrast, we relate these findings to concurrent processes that generate strongly positioned nucleosomes in vivo that are not mediated by sequence, such as energy-dependent remodeling of chromatin.
Transient PU.1 low fetal progenitors generate lymphoid progeny that contribute to adult immunity
Authors: Montecino-Rodriguez Encarnacion , Estrada Oscar I , Dorshkind Kenneth
Published: June 2024

Hematopoietic stem cells and multipotential progenitors emerge in multiple, overlapping waves of fetal development. Some of these populations seed the bone marrow and sustain adult B- and T-cell development long-term after birth. However, others are present transiently, but whether they are vestigial or generate B and T cells that contribute to the adult immune system is not well understood. We now report that transient fetal progenitors distinguished by expression of low levels of the PU.1 transcription factor generated activated and memory T and B cells that colonized and were maintained in secondary lymphoid tissues. These included the small and large intestines, where they may contribute to the maintenance of gut homeostasis through at least middle age. At least some of the activated/memory cells may have been the progeny of B-1 and marginal zone B cells, as transient PU.1lowfetal progenitors efficiently generated those populations. Taken together, our data demonstrate the potential of B- and T-cell progeny of transient PU.1lowfetal progenitors to make an early and long-term contribution to the adult immune system.
PLURALISMO JURÍDICO EN MÉXICO EN TIEMPOS DE COVID 19 Y LA CUARTA TRANSFORMACIÓN
Authors: Cruz Rueda Elisa
Published: June 2024

Abordamos el pluralismo jurídico en México como categoría jurídica y como categoría analítica de la relación entre el Estado mexicano y los pueblos indígenas, considerando tres aspectos: normativo, en el hacer justicia estatal y en la reivindicación de derechos por parte de los actores locales. El objetivo es mostrar las contradicciones en la instauración normativa del pluralismo jurídico y las tensiones sociales que muestran el alcance de ese reconocimiento. Analizaremos algunas sentencias y jurisprudencias y abordamos el caso del llamado proyecto de desarrollo Tren Maya, que representa la coronación de las reformas estructurales implementadas en sexenios anteriores, en el que confluyen la crisis humanitaria por la declaración de pandemia, la crisis de un sistema político que muestra sus contradicciones y la crisis del modelo económico mexicano que promueve programas económicos excluyentes. Abonamos en la revisión del pluralismo jurídico en el campo de la antropología jurídica.
MUJERES INDÍGENAS Y PLURALISMO JURÍDICO
Authors: Hernández Castillo Rosalva Aída , Cucurí Miñarcaja Cristina
Published: June 2024

En este artículo nos interesa analizar distintas experiencias de pluralismo jurídico en México y Ecuador, en donde la participación de las mujeres indígenas ha sido fundamental, tanto para replantear el derecho propio, como para reformular los términos en los que se da el reconocimiento a los derechos indígenas. Nos interesa abonar al debate en torno a la participación de las mujeres en el replanteamiento de los sistemas jurídicos indígenas, confrontando las perspectivas liberales de los derechos de las mujeres, que los plantean como contrarios a los derechos colectivos de los pueblos. Considerando el contexto de pandemia global en el que escribimos este texto, analizaremos también los retos que enfrentan estas luchas por la justicia en el marco de la crisis sanitaria del COVID19.
Palabras clave: Mujeres Indígenas, Pluralismo Jurídico, Justicias Indígenas.
TURISMO, DESIGUALDAD Y CRISIS:
Authors: Marín Guardado Gustavo
Published: June 2024

Presentación del dossier
PARA OBTENER Y DEFENDER LOS DERECHOS DE LOS AFRODESCENDIENTES, LA VOLUNTAD POLÍTICA DE GOBERNANTES ES PRIMORDIAL
Authors: Agudelo Carlos Efrén , Antón Sánchez Jhon , Muteba Rahier Jean
Published: June 2024

José Chalá Cruz, es un líder afroecuatoriano reconocido en el movimiento social afrodescendiente de América Latina. Es antropólogo y escritor. En esta entrevista habla de sus contribuciones a la creación de instrumentos étnico raciales a favor de los afroecuatorianos, tales como la Ley de Derechos Colectivos del Pueblo Afroecuatoriano (2006), los artículos de reconocimiento de derechos al pueblo afroecuatoriano en la Constitución del 2008, el decreto ejecutivo Nro 60 sobre acciones afirmativas, entre otros proyectos de leyes. Analiza el contexto en que se han desarrollado estos instrumentos legales étnico raciales desde tres experiencias personales: como activista social, como funcionario del gobierno y como legislador de la Asamblea Nacional. Su perspectiva se resume en que “hay una
diferencia entre lo que dice el papel (la ley) y la realidad”. Para José Chalá, actualmente “existe el peligro de derechizar al estado-nación, en donde la legislación a favor de los pueblos y las nacionalidades que hemos avanzado realmente tiene muy poca cabida. Es decir: aquí estamos ante, como diría Achille Mbembe (2016), en una parte de la necropolítica y también del necro- neoliberalismo, donde los pueblos pensados así, sujetos de derechos colectivos, acciones afirmativas, reparaciones, realmente no estamos vistos pese a la legislación que nosotros logramos. Ahí está la gran, gran diferencia”.
 
Palabras clave: Afrodescendencia, Derechos Colectivos, Leyes antidiscriminación, Neoliberalismo, Necropolitica.
COMPETÊNCIA TECNOLÓGICA PARA A REALIZAÇÃO DE ATIVIDADES EXPERIMENTAIS NAS AULAS DE FÍSICA
Authors: Rutz da Silva Silvio Luiz , Brinatti André Maurício , Chaves de Andrade André Vitor
Published: June 2024

Neste trabalho, apresentamos uma proposta de intervenção didática que contempla experimentos visuais e experimentos simulados com o uso de recursos tecnológicos. Faz-se uma análise de conteúdo e de contexto de uma disciplina de pós-graduação que contemplou a realização de oito atividades experimentais. A questão problema neste relato é como organizar atividades experimentais para incorporar recursos tecnológicos? O objetivo é desenvolver competências para a integração de recursos tecnológicos na experimentação por professores de física, trazendo para isso alguns exemplos. Como resultado temos que não há por que renunciar à realização de atividades experimentais, primeiro pela disponibilidade de grande número de tecnológicas digitais educativas; como segundo ponto destacamos que tais modalidades de atividades experimentais possibilitam introduzir o ensino com bases experimentais, mesmo em condições que aparentemente sejam pouco favoráveis.
Pembentukan Karakter Siswa: Studi Integrasi Nilai-Nilai Pendidikan Agama Islam Dalam Proyek Penguatan Profil Pelajar Pancasila dan Budaya Kerja (P5BK) di SMKN 1 Masbagik
Authors: Putra Yusril Mustapa , Supardi Supardi , Irrubai Moh. Liwa
Published: June 2024

This study aims to integrate Islamic Education values into the Strengthening Pancasila Student Profile and Work Culture Project (P5BK) to shape student character at SMKN 1 Masbagik. The research employs a qualitative descriptive method. Data were collected through interviews, observations, and document studies, and then analyzed using Miles and Huberman's interactive model. The results show that the integration of P5BK with Islamic Education values at SMKN 1 Masbagik is implemented through projects with themes of sustainable lifestyle, employability, and local wisdom. The implementation of P5BK involves four stages: planning, execution, evaluation, and supportive factors. The advantages of this integration include flexibility in implementation, synergy with the community and the workforce, and providing real-world experiences to foster student awareness of their environment and surrounding community. The theoretical implication of this research is its contribution to the support and enhancement of P5BK learning as part of the independent learning curriculum, which can improve teacher competence and the quality of education in vocational schools.
Education as a Solution: Understanding Religious Figures' Perspectives on Joint Property Division in East Lombok
Authors: Hasan Muh. Zaki , Masnun Masnun , Khaldun Rendra
Published: June 2024

This study explores the perspectives of religious figures regarding joint property division in East Lombok, aiming to elucidate the role of education as a potential solution in addressing related challenges. Employing a qualitative research approach, data was collected through semi-structured interviews with key religious figures in the region. These interviews were transcribed and analyzed thematically to identify recurring patterns and themes. The findings reveal a nuanced understanding among religious figures regarding joint property division, influenced by cultural, social, and religious factors. Education emerged as a central theme in their perspectives, highlighting its potential to foster understanding, tolerance, and equitable solutions. The implications of these findings underscore the importance of integrating educational initiatives into discussions and practices related to joint property division in East Lombok, thereby promoting social cohesion and conflict resolution.
THE INFLUENCE OF PROMOTIONS AND FLASH SALE ON THE DECISION TO USE THE SHOPEE APPLICATION IN MATARAM CITY
Authors: Dwi Yanti Yuni , Permadi Lalu Adi , Retnowati Weni
Published: June 2024

The aim of this research is to determine the significance of the influence of promotions and flash sales on decisions to use the Shopee application. The population of this research is Mataram city residents who have shopped on the Shopee application at least 1-3 times. The type of research used is quantitative research with a causal associative approach. Data collection techniques and tools use questionnaires distributed online. This research was located in Mataram City and the research population used a sample of 100 respondents. Using non-probability and purposive sampling techniques. The research results show that promotion has a positive and significant effect on the decision to use the Shopee application in the city of Mataram. Flash sales have a positive and significant effect on the decision to use the Shopee application in the city of Mataram.
 
The aim of this research is to determine the significance of the influence of promotions and flash sales on decisions to use the Shopee application. The population of this research is Mataram city residents who have shopped on the Shopee application at least 1-3 times. The type of research used is quantitative research with a causal associative approach. Data collection techniques and tools use questionnaires distributed online. This research was located in Mataram City and the research population used a sample of 100 respondents. Using non-probability and purposive sampling techniques. The research results show that promotion has a positive and significant effect on the decision to use the Shopee application in the city of Mataram. Flash sales have a positive and significant effect on the decision to use the Shopee application in the city of Mataram.
Programa de extensão universitária UFSM-Detecta: Ações de educação em saúde e diagnóstico molecular para o enfrentamento da COVID-19
Authors: Ruoso Terimar Facin , Vilande Fernanda Lopes , Ochoa Caroline Freitas , Graichen Daniel Ângelo Sganzerla , Batista Ângela Giovana
Published: June 2024

Diante da pandemia de COVID-19, muitas ações foram realizadas pelas universidades: identificação e caracterização do agente infeccioso; divulgação científica; formação dos profissionais de saúde; estudos sobre o tratamento, vacinas, diagnóstico; entre outros. No início da pandemia, isolar os portadores do SARS-Cov-2 a partir do diagnóstico rápido e preciso era a única forma de conter a disseminação do vírus. Neste contexto, o programa de extensão universitária denominado UFSM-Detecta, foi desenvolvido como parte de uma força tarefa institucional para minimizar os impactos da pandemia em uma região do Rio Grande do Sul. O programa teve como principal objetivo realizar a análise molecular do SARS-CoV-2 em uma região do estado distante da capital e com difícil acesso aos laboratórios de referência. O presente artigo tem como objetivo relatar a organização e vivências do referido programa. Para tal, foi realizado um estudo descritivo do tipo relato de experiência sobre uma ação extensionista ocorrida entre 2020 e 2023. Além de dados epidemiológicos e científicos gerados a partir da análise de 50.000 amostras vindas de 50 municípios parceiros, as ações de educação e divulgação científica realizadas neste período mostram a importância da integração da universidade com a sociedade. A extensão realiza, por excelência, o real sentido da universidade, integrando a ciência e o ensino, promovendo a democratização dos saberes num contexto interdisciplinar que contribui para o bem-estar e saúde da população.
A utilização de métodos matemáticos para previsão de demanda em uma distribuidora de óleos lubrificantes
Authors: pinto Geniarly Mendes , Feitosa Patrícia Silva , Oliveira Rafael Duarte Vieira de , Oliveira Rafael Duarte Vieira de
Published: June 2024

O objetivo deste trabalho foi avaliar a previsão de demanda utilizando métodos matemáticos comparando com a demanda requerida por produtos de uma empresa. Tratou-se de um estudo de caso, em uma distribuidora de óleo lubrificante de motores. Caracterizou-se como pesquisa  explicativa, aplicada e abordagem quantitativa. Foram utilizados relatórios mensais do período de abril de 2021 a julho de 2022. Os dados foram compilados no MS Excel sendo utilizados os métodos matemáticos de previsão de demanda da média móvel simples e suavizamento exponencial. Para acurácia do modelo empregado foi utilizado o desvio médio absoluto (MAD) e para o monitoramento da técnica de previsão foi utilizada a tendência de viés. A visão geral dos resultados encontrados mostrou que a utilização do método de previsão de demanda pela média móvel e por suavização exponencial, com coeficiente de 0,1, podem ser consideradas opções no processo de previsão com utilização de séries históricas.
Relationship between Particle Size, Anti-Microbial Activity and Leachability of Copper Particles in Liquid Suspension and Compounded in Polypropylene
Authors: Saleh Alkarri , Jérôme Vachon
Published: June 2024

Testing the antimicrobial efficiency of plastics with good precision and repeatability remains a challenge in the plastic industry, as commonly used standards can provide unreliable data. In this paper, we show that the “Bacterial Liquid Suspension Test” is a reliable method that allows for the measurement of antimicrobial activity of poor to very potent biocides. We used this technique to discriminate the performance of two Cu-based biocides, either in nanoparticle (NP) or macroparticle (MP) size, at three different loadings (0.02, 0.2 and 2 wt.%) in PP. With this technique, we also tested the antibacterial performance of PP as powders, pellets, and injection molded disks. As anticipated, the technique shows that both the increased loading and the smaller particle size showed higher antimicrobial activity than the larger particle size due to their increased surface area. Also, PP powders showed greater bacterial reduction than pellets and disks. While the PP with 2 wt.% Cu NPs showed the best antimicrobial performance, the detection of Cu at the surface (using SEM-EDX) and in the water leachate (using ICP-MS) were below the LODs, indicating their ability to kill bacteria.
Investigating Anti-Bacterial and Anti-COVID-19 Virus Properties and Mode of Action of Pure Mg(OH)2 and Copper-infused Mg(OH)2 Nanoparticles and Coated Polypropylene Surfaces
Authors: Saleh Alkarri , Melinda Frame , John Cairney , Lee Maddan , Jin H Kim , Jonathan O Rayner
Published: June 2024

Robust anti-microbial surfaces that are non-toxic to users have widespread application in medical, industrial, and domestic arenas. Magnesium hydroxide has recently gained attention as an anti-microbial compound that is non-toxic, biocompatible, and environmentally friendly. Here we demonstrate melt compound and thermally embossed methods for coating polypropylene with Mg(OH)2 nanoplatelets and copper-infused Mg(OH)2 nanoplatelets. Polypropylene articles coated with Mg(OH)2 nanoplatelets and copper-infused Mg(OH)2 nanoplatelets exhibit a log 8 kill of E.coli within 24 hours. In addition, Mg(OH)2 NPs suspension, at 0.25% reduced SARSCoV-2 virus titers in the solution by 2.5 x 103 PFU/mL or 29.4%, while the Cu-infused Mg(OH)2 NPs suspension, at 0.25% reduced titers by 8.1 x 103 PFU/mL or 95.3%. Fluorescence microscopy revealed that reactive oxygen species (ROS) are produced in bacteria in response to Mg(OH)2 and Cu-infused Mg(OH)2 nanoplatelets which appears to be an important but not the sole mode of anti-microbial action of the nanoplatelets. Plastics with anti-microbial surfaces from where biocides are non-leachable are highly desirable. This work provides a general fabrication strategy for developing anti-microbial plastic surfaces.
HIPEC application potential in the treatment of extensive carcinomatosis in ovarian cancer (retrospective study)
Authors: Radostev S. I. , Kolomiets L. A. , Shelekhov A. V. , Zubkov R. A. , Morikov D. D. , Medvednikov А. A.
Published: June 2024

Background. The high prevalence of advanced forms of cancer currently requires new treatment approaches. Only modern high-tech surgical procedures can provide means for improving the results of treatment.

The aim. To study the results of treatment of patients with ovarian cancer with symptoms of peritoneal carcinomatosis using the HIPEC (Hyperthermic IntraPEritoneal Chemotherapy) method.

Materials and methods. The study was conducted in Irkutsk Regional Cancer Center and included 88 patients. They were divided into 2 groups: group 1 – primary cytoreductive surgery (CRS) with the HIPEC method (41 patients); group 2 – primary cytoreductive surgery (47 patients). The most important criterion was the peritoneal cancer index (PCI). If the PCI was ≤ 14, we chose cytoreductive surgery with or without HIPEC.

Results. PCI analysis showed differences in its values between the study groups (CRS – 10.17 ± 0.952; CRS + HIPEC – 12.93 ± 0.744; p = 0.002). There was an increase in length of stay in patients who underwent major surgeries in combination with HIPEC (21.8 ± 0.9 days versus 14.5 ± 0.6 days in the CRS group; p = 0.001). The CRS + HIPEC group had a longer duration of surgery (394.88 ± 19.935 min vs. 172.98 ± 11.514 min in the CRS group; p = 0.001). There was an increase in the overall percentage of postoperative complications in the CRS + HIPEC group – up to 26.8 % without statistically significant differences with the CRS group – 8.5 % (p = 0.082). The median time of relapse onset in the CRS + HIPEC group was 26 ± 4.3 months, while in the CRS group it was 18 ± 2.6 months.

Conclusion. Using HIPEC method has proven its significance in increasing diseasefree survival.
Histological features of the structure of the long head of biceps brachii tendon in patients with concomitant injuries of the rotator cuff
Authors: Kolmakov D. O. , Zagorodniy N. V. , Korolev A. V. , Ilyin D. O. , Ushkova O. G.
Published: June 2024

Background. The long head of biceps brachii tendon plays an important role in shoulder pain. Surgical tactics remain controversial. There are two approaches: tenotomy of the long head of biceps brachii tendon and tenodesis. Both have positive and negative sides. There is also no consensus on the effective position for performing tenodesis.

The aim. To assess the histological structure of various parts of the long head of biceps brachii tendon, which may be the causes for persistent pain syndrome.

Materials and methods. In this study, we examined the histological structure of the long head of biceps brachii tendon in 12 patients aged 18–59 years having chronic anterior shoulder pain with concomitant damage to the supraspinatus and subscapularis tendons. In all cases, magnetic resonance imaging (MRI) revealed changes that made it impossible to perform intraarticular tenodesis. Patients were divided into two groups according to the World Health Organization classification: young (18–44 years) and middle-aged (45–59 years). All patients underwent arthroscopy with subpectoral tenodesis and correction of concomitant pathology. The obtained macropreparations are divided into three zones: the proximal zone, the intertubercular zone and the zone below the intertubercular groove. All macropreparations were sent for histological examination.

It was revealed that the most common changes occur in the area of the intertubercular groove in all categories, however, in the middle-aged group, the signs of inflammation and degeneration are equally evident in this zone and in the proximal part of the tendon.

Conclusions. Young and middle-aged patients with damage to the tendons of the supraspinatus and subscapularis muscles and signs of chronic tendinitis of the long head of biceps brachii tendon tendon and pronounced structural changes according to MRI should undergo a subpectoral tenodesis procedure; it is also necessary to take into account the anatomical features of the tendon and possible surgical risks.
Assessment of the therapeutic effect of the drug Molixan in the treatment of Syrian hamsters experimentally infected with the SARS-CoV-2 virus
Authors: Gulyaeva M. A. , Shestopalova L. V. , Din X. , Alekseev A. Yu. , Markhaev A. G. , Filippova А. Yu. , Antonov V. G. , Trashkov A. P. , Shestopalov A. M.
Published: June 2024

Background. Studying the characteristics of the course of coronavirus infection caused by SARS-CoV-2 remains relevant due to the high mutagenicity of the virus and the prevalence of the disease in the world. The search for new drugs to eliminate clinical manifestations of COVID-19, as well as against its agent, is essential. During the pandemic caused by SARS-CoV-2, dexamethasone was recognized as the only effective anti-inflammatory drug for the treatment of patients with severe form of the disease, but its use leads to a large number of side effects.

The aim. To study the therapeutic effect of the drug Molixan in the treatment of coronavirus infection in model animals – Syrian hamsters.

Methods. To assess the effectiveness of the drug Molixan, we carried out a visual assessment of the condition of the lungs using light microscopy and the morphometry of the lung tissue of experimentally infected Syrian hamsters on the day 6 after infection under different Molixan treatment regimens and during dexamethasone therapy. The test drug was administered using three different doses (22.2 mg/kg, 44.4 mg/kg and 88.8 mg/kg, which are equivalent to doses of 3 mg/kg, 6 mg/kg and 12 mg/kg of human body weight) once daily or dividing the dose into two within 12 h interval in case of multiple (5 days) intramuscular administration. Dexamethasone (comparison drug) was administered at a dose of 20 mg/kg once daily for 5 days.

Results. The studies showed statistically significant effectiveness of using Molixan at a dose of 44.4 mg/kg, divided into two doses, during 5 days. When compared with untreated hamsters, this treatment regimen reduces the degree of generalization and severity of the inflammatory process in the lungs; and the pathomorphological picture is similar to that observed during treatment with Dexamethasone.

Conclusion. The studied drug Molixan is effective as an anti-inflammatory drug in the treatment of the disease caused by SARS-CoV-2.
Pharmaceutical composition of 1,2,4-trioxolanes with betulin in fish oil. Effect on oxidative and energy metabolism in the treatment of burns in rats
Authors: Malygina D. S. , Yastrebov P. V. , Fayans A. E. , Spitskaya I. V. , Esipovich A. L. , Soloveva А. G. , Peretyagin P. V. , Melnikova N. B.
Published: June 2024

Background. Ozonation products of unsaturated fatty acids in fats and oils – 1,2,4-trioxolanes – which contribute to the normalization of oxidative and energy metabolism in various diseases, may be a promising substance for the creation of new combined anti-burn drugs.

The aim. To study the effect of 1,2,4-trioxolanes in a pharmaceutical composition with betulin, which exhibits wound-healing properties, on indicators of oxidative stress and on energy metabolism in the treatment of burns in an experiment onrats. Methods. The experiments were carried out on 50 male Wistar rats with seconddegree skin burns. We assessed the activity of glutathione reductase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, aldehyde dehydrogenase, superoxide dismutase and catalase, as well as the level of lipid peroxidation indicators.

Results. The properties of 1,2,4-trioxolanes were studied and a pharmaceutical composition of 1,2,4-trioxolanes with betulin from birch bark in fish oil was developed. The effect of this composition on oxidative and energy metabolism in rats during the treatment of burns was studied. The activation of NADP/H and NAD/H dependent enzymes (glutathione reductase, glucose-6-phosphate dehydrogenase, lactate dehydrogenase, aldehyde dehydrogenase), as well as superoxide dismutase and catalase, and the normalization of lipid peroxidation parameters under the influence of the studied composition in the treatment of burns were revealed. The effect of the composition on the energy metabolism of erythrocytes was noted, which was assessed by changes in the ratio of lactate dehydrogenase activity in the reverse and direct reactions. Morphohistological studies showed that using the composition under normal conditions and in case of a burn had no effect on the structure of the stomach wall, and also improved the condition of the burn wound on the day 10 compared to the wound condition in animals without treatment.

Conclusion. The proposed composition of 1,2,4-trioxolanes and betulin in fish oil, which allows normalizing oxidative and energy metabolism and improving the condition of a burn wound without toxic effects on the stomach wall, can be used as an element of additional therapy in the treatment of burns.
Clinical case of pregnancy complicated by thrombotic thrombocytopenic purpura
Authors: Semenova M. V. , Sarrakhov D. D. , Gilimkhanova A. R. , Kamalova A. R. , Vakhitov P. G. , Musina А. A. , Islamgaraev B. A.
Published: June 2024

Background. Thrombotic thrombocytopenic purpura is a rare blood disease characterized by increased thrombogenesis in the microcirculation. One of the most common triggers for the development of this disease is pregnancy. The article describes a case of pregnancy complicated by thrombotic thrombocytopenic purpura.

Materials and methods. To assess the clinical case, we used a retrospective analysis of medical documentation: maternity case record, birth history, results of laboratory and instrumental research methods.

Results. A 32-year-old patient was admitted to hospital at week 32 of gestation with manifestations of moderate preeclampsia, thrombocytopenia, and moderate anemia. Due to worsening of the condition, the delivery was performed by cesarean section. Subsequently, the mother’s condition did not improve: thrombocytopenia and hyperbilirubinemia progressed; the level of transaminases increased; ADAMTS13 activity was 8 %. Teleconferences were repeatedly held with experts from the National Medical Research Center for Obstetrics, Gynecology and Perinatology named after Academician V.I. Kulakov (Moscow). Complex therapy including extracorporeal methods led to a positive result; the patient was discharged in satisfactory condition under the supervision of a hematologist and obstetrician-gynecologist.

Conclusion. Thrombotic thrombocytopenic purpura treatment tactics have its own characteristics; it is necessary to diagnose this pathology in a timely manner to provide qualified medical care and to prevent maternal and perinatal losses.
Clinical and laboratory prognostic factors in patients with mixed infection of erythema form of ixodic tick-borne borreliosis and tick-borne encephalitis
Authors: Ilyinskikh E. N. , Filatova E. N. , Semenova A. V. , Samoylov K. V. , Portnyagina E. V. , Minakova Iu. V. , Kolganova G. N.
Published: June 2024

Background. Early diagnosis of the mixed infection of ixodic tick-borne borreliosis and tick-borne encephalitis can be difficult without laboratory confirmation of the diagnosis.

The aim. To assess clinical and laboratory predictors in patients for building the models of early differential diagnosis between mixed infection of erythema form of ixodic tick-borne borreliosis and febrile form of tick-borne encephalitis and monoinfection of erythema form of ixodic tick-borne borreliosis.

Materials and methods. The clinical study included 26 patients with mixed infection of the erythema form of ixodic tick-borne borreliosis with tick-borne encephalitis (mean age – 46.7 years) and 30 patients with monoinfection of the erythema form of ixodic tick-borne borreliosis (mean age – 48.5 years). 59 clinical, epidemiological and laboratory parameters, including 6 leukocyte blood indices, standard and extended hemogram profiles were studied in these patients the first week of the disease. For statistical analysis, we used Pearson and Mann – Whitney goodness-of-fit tests, ROC analysis with calculation of the area under curve (AUC) and logistic regression. Results. Patients with mixed infection, compared to the patients with monoinfection, had increased odds of having febrile fever, weakness, headache and orbital pain; meningism symptoms occurred only in patients with mixed infection. Early predictors of a preliminary diagnosis of mixed infection were elevated values of fever (AUC = 0.87), intoxication syndrome score (AUC = 0.71), leukocyte count (AUC = 0.64) and neutrophils (AUC = 0.71) in the hemogram, levels of leukocyte intoxication index according to V.K. Ostrovsky (AUC = 0.67) and neutrophil-leukocyte index (AUC = 0.65), as well as a decrease in the number of platelets (AUC = 0.77), eosinophils (AUC = 0.72) and basophils (AUC = 0.79) in peripheral blood. Two prognostic models which included clinical and laboratory parameters demonstrated excellent prediction of mixed infection (AUC = 0.90 and AUC = 0.91).

Conclusion. Early clinical and laboratory predictors have been established and models have been developed that make it possible, with excellent prognosis quality, to calculate in patients the probability of a preliminary diagnosis of mixed infection of the erythema form of ixodic tick-borne borreliosis with tick-borne encephalitis in comparison with borreliosis monoinfection.
The learning activities of RBL-STEM: Prototyping a water-powered lamp to enhance students' climate change literacy
Authors: Ike Khusniyawati  , Dafik  , A. A. Ketut Budiastra
Published: June 2024

Addressing climate change and the finite nature of fossil fuels necessitates proactive solutions, one of which is embedding climate change literacy within educational frameworks. This form of literacy aims to equip students with a comprehensive understanding of the concepts, causes, impacts, and potential solutions related to climate change. An educational approach that integrates these elements is the RBL-STEM learning model, particularly through the study of Renewable Energy. For instance, students engage in practical activities like constructing simple water-powered lights, which helps con textualize energy availability issues. This developmental research employed the 4D model to create and refine teaching modules, student worksheets (LKPD), and assessments for climate change literacy. The effectiveness of these materials was evaluated with a cohort of 25 fourth-grade students at SDN Tenggilis Mejoyo I in Surabaya. The findings indicated that the RBL-STEM learning resources related to Renewable Energy were well-designed, effective, and suitable for educational use. Importantly, they significantly enhanced the students' understanding and literacy regarding climate change, demonstrating the value of integrating hands-on, practical learning experiences in the curriculum to foster a deeper awareness and knowledge of renewable energy and climate-related issues.
Contributions of waterfall to poverty alleviation in rural communities
Authors: Tolulope Enitan OLUYEMI  , Damola Sodiq SHITU
Published: June 2024

This research focused on the role of Arinta Waterfall in alleviating poverty in the rural community of Ipole Iloro, Ekiti State, Nigeria, and utilised a survey-based methodology that included data collection through questionnaires. The analysis of 285 questionnaires, cleaned and processed with SPSS, revealed positive economic and infrastructure impacts due to the waterfall presence, including increased government revenue, improved road networks, the establishment of a primary health centre, and the provision of essential community amenities. To fully harness Arinta Waterfall's tourism potential, it is recommended to prioritize local infrastructure enhancement, implement more effective marketing strategies, and actively engage the community. The study employed a multi-stage sampling process, involving three randomly selected quarters from Ipole Iloro with an initial sample size of 450 residents. Purposive sampling targeted youth and the elderly, reducing the sample to 315 respondents, and ensuring a representative selection of rural dwellers.
Puzzle Fisika Berbasis Make a Match: Pengembangan Media Pembelajaran terhadap Hasil Belajar Siswa SMA Kelas XI
Authors: Reni Setiawati  , Rosa Sinensis Arini , Effendi Effendi
Published: June 2024

This research aims to develop physics puzzle learning media based on make a match and evaluate the impact of this media on improving student learning outcomes. This research uses the Research and Development using the Borg & Gall procedural model from ten phases to seven phases because these seven include ten processes. The data collection methods used include media expert and material expert validation sheets, test instruments in the form of essay questions and student response questionnaires. The results of this research show that, 1) The make a match based physics puzzle learning media developed in this research has succeeded in meeting the feasible criteria with an average score percentage of 88% given by media experts in the very feasible category. Apart from that, material experts also assessed that learning media with an average score percentage of 94% was in the very appropriate category. 2) The use of make a match-based physics puzzle learning media has been proven to significantly improve student learning outcomes, as indicated by an N-Gain analysis score of 0.72. 3) Student responses to the appearance and function of the media show a high level of feasibility. The learning media that has been developed is feasible and can be used to improve student learning outcomes in circular motion material
Strategi Pendekatan Historis Dan Pragmatis
Authors: Achmad Faris Fizabillah  , Silvia Damayanti  , Muhammad Yasin
Published: June 2024

This research examines the "Historical and Pragmatic Approach Strategy" in the context of policy analysis and implementation. The historical approach focuses on tracing policy developments from the past to understand the context and factors that influenced their formation. Meanwhile, the pragmatic approach emphasizes implementing practical solutions that are adaptive to current situations and dynamic needs. Through a combination of these two approaches, this research aims to produce a more comprehensive and responsive policy strategy. This study uses qualitative methods with secondary data analysis from various historical and contemporary policy sources. The research results show that a combination of historical and pragmatic approaches can increase policy effectiveness by enriching understanding of the roots of problems and offering solutions that are relevant and applicable in the current context.
Ympäristöaktivismin moninaisuus, tunteet ja tilallisuus
Authors: Kettunen Marika
Published: June 2024

Virpi Suutarin ohjaama dokumenttielokuva Havumetsän lapset osallistuu ajankohtaiseen keskusteluun metsistä ja metsäluonnonsuojelusta. Elokuva herättää pohtimaan, millaista on elää nuoruutta ja toimia luonnonsuojelun eteen 2020-luvun Suomessa. Tässä tekstissä tuon esiin dokumenttielokuvan avaamia näkökulmia (metsä)luonnonsuojeluun ja nuorten ympäristöaktivismiin kolmen teeman kautta. Nämä kolme toisiinsa kietoutuvaa teemaa ovat usein suurelle yleisölle näkymättömäksi jäävä ympäristöaktivismin monimuotoisuus, vaikeasti sanoitettava, mutta sitäkin selvemmin aistittavissa oleva ympäristöaktivismin tunnemaisema sekä ympäristöaktivismin paikat ja tilallisuus. Lopuksi pohdin, millaisiin maantieteen ja yhteiskunnallisen ympäristötutkimuksen kentillekin soveltuviin kysymyksenasetteluihin nämä teemat voisivat nivoutua.
Кузбасс: возможности инновационно-инвестиционного роста
Authors: Фридман Ю.А. , Речко Г.Н. , Логинова Е.Ю.
Published: June 2024

Несмотря на официально провозглашенную и закрепленную в документах стратегического планирования Кемеровской области – Кузбасса нацеленность на инновационно-инвестиционный путь развития, у региона до сих пор нет общепризнанной концепции такого развития, а сложившаяся структура экономики не способствует инновационному росту. Представленные в статье результаты анализа воспроизводственной структуры экономики Кузбасса показывают, что инновационно-инвестиционный блок отраслей на протяжении последних полутора десятков лет здесь практически не развивался, и многие необходимые его элементы отсутствуют. Ставка на передовые западные технологии, что активно практиковал регион в конце 1990-х – начале 2000-х гг., в настоящее время не работает. Кемеровской области в обозримой перспективе предстоит выработать новую модель инновационно-инвестиционного роста, которая будет нацелена на адаптацию к новым вызовам, и опираться на ограниченный научно-технологический и инвестиционный потенциал. Одним из наиболее вероятных мегапроектов такой модели развития для региона может стать глубокая переработка угля.
PROGRAM PELATIHAN DETEKSI DINI DAN STIMULASI TUMBUH KEMBANG PADA ORANG TUA SERTA GURU ANAK USIA 3-6 TAHUN DI TK DHARMA WANITA DUKUH 2 KECAMATAN NGADILUWIH
Authors: Wulaningtyas Eko Sri , Yanti Entin Srihadi , Dari Puspo , Alsabah M. Akbar Husein , Puspitasari Oktavia , Fauziah Asmaul , Rahmadini Siska Nuriya , Bale Emerensiana
Published: June 2024

Kegiatan Pengabdian kepada Masyarakat (PKM) berupa â€œProgram Pelatihan Deteksi Dini Dan Stimulasi Tumbuh Kembang Pada Orang tua serta guru Anak Usia 3-6 Tahun Di TK Dharma Wanita Dukuh 2 Kecamatan Ngadiluwihâ€. Program ini dilatarbelakangi indikator SDGâ€™s 4.2.1 yaitu anak usia dibawah 5 tahun yang berkembang dengan baik (on the track) dalam bidang Kesehatan, pembelajaran dan psikososial (BPS, 2018). Populasi anak Indonesia mencapai 31,56 % dari total seluruh penduduk, yaitu 84.4 juta anak (Kemen PPPA, 2020). Terdapat lebih dari 200 juta anak balita di seluruh dunia diperkirakan mengalami gangguan perkembangan kognitif dan sosial emosional (Zhang J et al, 2018). Anak menjadi modal kemajuan bangsa yang perlu mendapat jaminan pertumbuhan dan perkembangan yang optimal (BPS, 2018). Setiap orang tua mengharapkan tumbuh kembang optimal bagi anak mereka, sayangnya hal ini tidak diiringi pengetahuan dan kemampuan yang optimal dan deteksi dini serta stimulasi tumbuh kembang anak. Penelitian menunjukkan adanya hubungan antara pengetahuan ibu terhadap perkembangan motorik anak usia balita di TK Dharma Wanita Desa Ringinsari Kediri (Eko Sri, 2022).Â  Tujuan kegiatan PKM yaitu 1) menjadi program percontohan dalam optimalisasi tumbuh kembang anak usia 3-6 tahun; 2) meningkatkan pengetahuan dan kemampuan orang tua dan guru yang memiliki/mengajar anak usia 3-6 tahun untuk dapat melakukan deteksi dini dan simulasi tumbuh kembang secara mandiri dan berkesinambungan. Target luaran yang ingin dicapai yaitu publikasi artikel pada jurnal ber ISSN (luaran wajib) serta modul aplikatif. Metode yang digunakan berupa penyuluhan, demo, pelatihan dan monitoring pasca kegiatan. Kegiatan PKM berlangsung selama 6 bulan (Agustus sampai Januari 2022).