bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Materials from Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent
Authors: Chang Bao-Li , Spangler Elaine , Gallagher Stephen , Haiman Christopher A. , Henderson Brian , Isaacs William , Benford Marnita L. , Kidd LaCreis R. , Cooney Kathleen , Strom Sara , Ingles Sue Ann , Stern Mariana C. , Corral Roman , Joshi Amit D. , Xu Jianfeng , Giri Veda N. , Rybicki Benjamin , Neslund-Dudas Christine , Kibel Adam S. , Thompson Ian M. , Leach Robin J. , Ostrander Elaine A. , Stanford Janet L. , Witte John , Casey Graham , Eeles Rosalind , Hsing Ann W. , Chanock Stephen , Hu Jennifer J. , John Esther M. , Park Jong , Stefflova Klara , Zeigler-Johnson Charnita , Rebbeck Timothy R.
Published: March 2023

Supplementary Materials from Validation of Genome-Wide Prostate Cancer Associations in Men of African Descent
Supplementary Table 1 from Reduced Overall and Event-Free Survival among Colon Cancer Patients Using Dual System Care
Authors: Tarlov Elizabeth , Lee Todd A. , Weichle Thomas W. , Durazo-Arvizu Ramon , Zhang Qiuying , Perrin Ruth , Bentrem David , Hynes Denise M.
Published: March 2023

PDF file - 51K, Administrative codes used to define comorbidities, colon cancer treatment, and colon events
Supplementary Figure 2 from Epigenetic Deregulation Across Chromosome 2q14.2 Differentiates Normal from Prostate Cancer and Provides a Regional Panel of Novel DNA Methylation Cancer Biomarkers
Authors: Devaney James , Stirzaker Clare , Qu Wenjia , Song Jenny Z. , Statham Aaron L. , Patterson Kate I. , Horvath Lisa G. , Tabor Bruce , Coolen Marcel W. , Hulf Toby , Kench James G. , Henshall Susan M. , Pe Benito Ruth , Haynes Anne-Maree , Mayor Regina , Peinado Miguel A. , Sutherland Robert L. , Clark Susan J.
Published: March 2023

Supplementary Figure 2 from Epigenetic Deregulation Across Chromosome 2q14.2 Differentiates Normal from Prostate Cancer and Provides a Regional Panel of Novel DNA Methylation Cancer Biomarkers
Data Supplement from Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study
Authors: Muti Paola , Sacconi Andrea , Hossain Ahmed , Donzelli Sara , Ben Moshe Noa Bossel , Ganci Federica , Sieri Sabina , Krogh Vittorio , Berrino Franco , Biagioni Francesca , Strano Sabrina , Beyene Joseph , Yarden Yosef , Blandino Giovanni
Published: March 2023

Supplementary Figure 1. qRT-PCR analysis of miR-145-5p expression in MDA-MB-231 cells used for proliferation assay.
Data Supplement from Downregulation of microRNAs 145-3p and 145-5p Is a Long-term Predictor of Postmenopausal Breast Cancer Risk: The ORDET Prospective Study
Authors: Muti Paola , Sacconi Andrea , Hossain Ahmed , Donzelli Sara , Ben Moshe Noa Bossel , Ganci Federica , Sieri Sabina , Krogh Vittorio , Berrino Franco , Biagioni Francesca , Strano Sabrina , Beyene Joseph , Yarden Yosef , Blandino Giovanni
Published: March 2023

Figure Legend Supplementary Material
Supplementary Table 2 from Comparative Biomarker Expression and RNA Integrity in Biospecimens Derived from Radical Retropubic and Robot-Assisted Laparoscopic Prostatectomies
Authors: Ricciardelli Carmela , Bianco-Miotto Tina , Jindal Shalini , Dodd Thomas J. , Cohen Penelope A. , Marshall Villis R. , Sutherland Peter D. , Samaratunga Hemamali , Kench James G. , Dong Ying , Wang Hong , Clements Judith A. , Risbridger Gail P. , Sutherland Robert L. , Tilley Wayne D. , Horsfall David J.
Published: March 2023

Supplementary Table 2 from Comparative Biomarker Expression and RNA Integrity in Biospecimens Derived from Radical Retropubic and Robot-Assisted Laparoscopic Prostatectomies
Supplementary Table 1 from Leukocyte Telomere Length in Relation to Pancreatic Cancer Risk: A Prospective Study
Authors: Campa Daniele , Mergarten Björn , De Vivo Immaculata , Boutron-Ruault Marie-Christine , Racine Antoine , Severi Gianluca , Nieters Alexandra , Katzke Verena A. , Trichopoulou Antonia , Yiannakouris Nikos , Trichopoulos Dimitrios , Boeing Heiner , Quirós J. Ramón , Duell Eric J. , Molina-Montes Esther , Huerta José María , Ardanaz Eva , Dorronsoro Miren , Khaw Kay-Tee , Wareham Nicholas , Travis Ruth C. , Palli Domenico , Pala Valeria , Tumino Rosario , Naccarati Alessio , Panico Salvatore , Vineis Paolo , Riboli Elio , Siddiq Afshan , Bueno-de-Mesquita H.B. , Peeters Petra H. , Nilsson Peter M. , Sund Malin , Ye Weimin , Lund Eiliv , Jareid Mie , Weiderpass Elisabete , Duarte-Salles Talita , Kong So Yeon , Stepien Magdalena , Canzian Federico , Kaaks Rudolf
Published: March 2023

Supplementary Table 1 - Associations between LTL and pancreatic cancer risk adjusted for smoking status C-peptide and HbA1c levels
Supplementary Figure 1 from Leukocyte Telomere Length in Relation to Pancreatic Cancer Risk: A Prospective Study
Authors: Campa Daniele , Mergarten Björn , De Vivo Immaculata , Boutron-Ruault Marie-Christine , Racine Antoine , Severi Gianluca , Nieters Alexandra , Katzke Verena A. , Trichopoulou Antonia , Yiannakouris Nikos , Trichopoulos Dimitrios , Boeing Heiner , Quirós J. Ramón , Duell Eric J. , Molina-Montes Esther , Huerta José María , Ardanaz Eva , Dorronsoro Miren , Khaw Kay-Tee , Wareham Nicholas , Travis Ruth C. , Palli Domenico , Pala Valeria , Tumino Rosario , Naccarati Alessio , Panico Salvatore , Vineis Paolo , Riboli Elio , Siddiq Afshan , Bueno-de-Mesquita H.B. , Peeters Petra H. , Nilsson Peter M. , Sund Malin , Ye Weimin , Lund Eiliv , Jareid Mie , Weiderpass Elisabete , Duarte-Salles Talita , Kong So Yeon , Stepien Magdalena , Canzian Federico , Kaaks Rudolf
Published: March 2023

Supplementary Figure 1 - non-linear relation with 4 knots restricted cubic spline between LTL and pancreatic cancer risk.
Data Supplement from Gene–Environment Interaction Involving Recently Identified Colorectal Cancer Susceptibility Loci
Authors: Kantor Elizabeth D. , Hutter Carolyn M. , Minnier Jessica , Berndt Sonja I. , Brenner Hermann , Caan Bette J. , Campbell Peter T. , Carlson Christopher S. , Casey Graham , Chan Andrew T. , Chang-Claude Jenny , Chanock Stephen J. , Cotterchio Michelle , Du Mengmeng , Duggan David , Fuchs Charles S. , Giovannucci Edward L. , Gong Jian , Harrison Tabitha A. , Hayes Richard B. , Henderson Brian E. , Hoffmeister Michael , Hopper John L. , Jenkins Mark A. , Jiao Shuo , Kolonel Laurence N. , Le Marchand Loic , Lemire Mathieu , Ma Jing , Newcomb Polly A. , Ochs-Balcom Heather M. , Pflugeisen Bethann M. , Potter John D. , Rudolph Anja , Schoen Robert E. , Seminara Daniela , Slattery Martha L. , Stelling Deanna L. , Thomas Fridtjof , Thornquist Mark , Ulrich Cornelia M. , Warnick Greg S. , Zanke Brent W. , Peters Ulrike , Hsu Li , White Emily
Published: March 2023

Provides an overview of the methods for each of the included studies
Supplementary Table 1 from A Peripheral Circulating TH1 Cytokine Profile Is Inversely Associated with Prostate Cancer Risk in CLUE II
Authors: Bhavsar Nrupen A. , Bream Jay H. , Meeker Alan K. , Drake Charles G. , Peskoe Sarah B. , Dabitao Djeneba , De Marzo Angelo M. , Isaacs William B. , Platz Elizabeth A.
Published: March 2023

Risk of prostate cancer excluding cases diagnosed within 2 and 5 years comparing highest quartilea of cytokine concentration with lowest quartile_a of concentration, CLUE II.
Supplementary Figure 2B from Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer
Authors: Roylance Rebecca , Endesfelder David , Gorman Patricia , Burrell Rebecca A. , Sander Jil , Tomlinson Ian , Hanby Andrew M. , Speirs Valerie , Richardson Andrea L. , Birkbak Nicolai J. , Eklund Aron C. , Downward Julian , Kschischo Maik , Szallasi Zoltan , Swanton Charles
Published: March 2023

PDF file - 199K, Distribution of centromere signals for MCD1 and MCD4 ER-negative breast cancer patients: Histograms of centromere numbers for chromosome 15.
Supplementary Figure 1 from Relationship of Extreme Chromosomal Instability with Long-term Survival in a Retrospective Analysis of Primary Breast Cancer
Authors: Roylance Rebecca , Endesfelder David , Gorman Patricia , Burrell Rebecca A. , Sander Jil , Tomlinson Ian , Hanby Andrew M. , Speirs Valerie , Richardson Andrea L. , Birkbak Nicolai J. , Eklund Aron C. , Downward Julian , Kschischo Maik , Szallasi Zoltan , Swanton Charles
Published: March 2023

PDF file - 201K, Heatmap of centromeric distribution for ER-negative and ER-positive breast cancer patients: Separate heatmaps for ER-negative and ER-positive cancers showing the centromeric distribution for chromosome 2 and 15 ranked according to MCD cohort, with corresponding HER2 status (center colourbar): HER2 negative (red) HER2 positive (black). The heatmap columns indicate the centromere number for each chromosome per nucleus and colours represent the percentage of nuclei having that particular centromere number (blue = 0%, red = 100%). For diagrammatic purposes the figure only portrays centromere counts between one and five.
Related Article from Can UV Exposure Reduce Mortality?
Authors: Berwick Marianne
Published: March 2023

Related Article from Can UV Exposure Reduce Mortality?
Supplementary Appendices 1 and 2 from MicroRNA Signatures: Novel Biomarker for Colorectal Cancer?
Authors: Luo Xiaoya , Burwinkel Barbara , Tao Sha , Brenner Hermann
Published: March 2023

Supplementary Appendices 1 and 2 from MicroRNA Signatures: Novel Biomarker for Colorectal Cancer?
Supplementary Text from Childhood Exposure to Secondhand Smoke and Functional Mannose Binding Lectin Polymorphisms Are Associated with Increased Lung Cancer Risk
Authors: Olivo-Marston Susan E. , Yang Ping , Mechanic Leah E. , Bowman Elise D. , Pine Sharon R. , Loffredo Christopher A. , Alberg Anthony J. , Caporaso Neil , Shields Peter G. , Chanock Stephen , Wu Yanhong , Jiang Ruoxiang , Cunningham Julie , Jen Jin , Harris Curtis C.
Published: March 2023

Supplementary Text from Childhood Exposure to Secondhand Smoke and Functional Mannose Binding Lectin Polymorphisms Are Associated with Increased Lung Cancer Risk
Supplementary Table 1 from Smoking and Passive Smoking in Cervical Cancer Risk: Pooled Analysis of Couples from the IARC Multicentric Case–Control Studies
Authors: Louie Karly S. , Castellsague Xavier , de Sanjose Silvia , Herrero Rolando , Meijer Chris J. , Shah Keerti , Munoz Nubia , Bosch F. Xavier
Published: March 2023

Supplementary Table 1 from Smoking and Passive Smoking in Cervical Cancer Risk: Pooled Analysis of Couples from the IARC Multicentric Case–Control Studies
Supplementary Tables 1-3 from Is Human Papillomavirus Viral Load a Clinically Useful Predictive Marker? A Longitudinal Study
Authors: Constandinou-Williams Christothea , Collins Stuart I. , Roberts Sally , Young Lawrence S. , Woodman Ciaran B.J. , Murray Paul G.
Published: March 2023

Supplementary Tables 1-3 from Is Human Papillomavirus Viral Load a Clinically Useful Predictive Marker? A Longitudinal Study
Supplementary Table 2 from Childhood Exposure to Secondhand Smoke and Functional Mannose Binding Lectin Polymorphisms Are Associated with Increased Lung Cancer Risk
Authors: Olivo-Marston Susan E. , Yang Ping , Mechanic Leah E. , Bowman Elise D. , Pine Sharon R. , Loffredo Christopher A. , Alberg Anthony J. , Caporaso Neil , Shields Peter G. , Chanock Stephen , Wu Yanhong , Jiang Ruoxiang , Cunningham Julie , Jen Jin , Harris Curtis C.
Published: March 2023

Supplementary Table 2 from Childhood Exposure to Secondhand Smoke and Functional Mannose Binding Lectin Polymorphisms Are Associated with Increased Lung Cancer Risk
Supplementary Table 1 from Telomere Length and TERT Functional Polymorphisms Are Not Associated with Risk of Squamous Cell Carcinoma of the Head and Neck
Authors: Liu Zhensheng , Ma Hongxia , Wei Sheng , Li Guojun , Sturgis Erich M. , Wei Qingyi
Published: March 2023

PDF file - 62KB, Subject information.
Supplementary Table 3 from 9q31.2-rs865686 as a Susceptibility Locus for Estrogen Receptor-Positive Breast Cancer: Evidence from the Breast Cancer Association Consortium
Authors: Warren Helen , Dudbridge Frank , Fletcher Olivia , Orr Nick , Johnson Nichola , Hopper John L. , Apicella Carmel , Southey Melissa C. , Mahmoodi Maryam , Schmidt Marjanka K. , Broeks Annegien , Cornelissen Sten , Braaf Linda M. , Muir Kenneth R. , Lophatananon Artitaya , Chaiwerawattana Arkom , Wiangnon Surapon , Fasching Peter A. , Beckmann Matthias W. , Ekici Arif B. , Schulz-Wendtland Ruediger , Sawyer Elinor J. , Tomlinson Ian , Kerin Michael , Burwinkel Barbara , Marme Frederik , Schneeweiss Andreas , Sohn Christof , Guénel Pascal , Truong Thérèse , Laurent-Puig Pierre , Mulot Claire , Bojesen Stig E , Nielsen Sune F. , Flyger Henrik , Nordestgaard Børge G , Milne Roger L. , Benítez Javier , Arias-Pérez José-Ignacio , Zamora M. Pilar , Anton-Culver Hoda , Ziogas Argyrios , Bernstein Leslie , Dur Christina Clarke , Brenner Hermann , Müller Heiko , Arndt Volker , Langheinz Anne , Meindl Alfons , Golatta Michael , Bartram Claus R. , Schmutzler Rita K. , Brauch Hiltrud , Justenhoven Christina , Brüning Thomas , Chang-Claude Jenny , Wang-Gohrke Shan , Eilber Ursula , Dörk Thilo , Schürmann Peter , Bremer Michael , Hillemanns Peter , Nevanlinna Heli , Muranen Taru A. , Aittomäki Kristiina , Blomqvist Carl , Bogdanova Natalia , Antonenkova Natalia , Rogov Yuriy , Bermisheva Marina , Prokofyeva Darya , Zinnatullina Guzel , Khusnutdinova Elza , Lindblom Annika , Margolin Sara , Mannermaa Arto , Kosma Veli-Matti , Hartikainen Jaana M. , Kataja Vesa , Chenevix-Trench Georgia , Beesley Jonathan , Chen Xiaoqing , Lambrechts Diether , Smeets Ann , Paridaens Robert , Weltens Caroline , Flesch-Janys Dieter , Buck Katharina , Behrens Sabine , Peterlongo Paolo , Bernard Loris , Manoukian Siranoush , Radice Paolo , Couch Fergus J. , Vachon Celine , Wang Xianshu , Olson Janet , Giles Graham , Baglietto Laura , McLean Cariona A. , Severi Gianluca , John Esther M. , Miron Alexander , Winqvist Robert , Pylkäs Katri , Jukkola-Vuorinen Arja , Grip Mervi , Andrulis Irene L. , Knight Julia A. , Mulligan Anna Marie , Weerasooriya Nayana , Devilee Peter , Tollenaar Robert A.E.M. , Martens John W.M. , Seynaeve Caroline M. , Hooning Maartje J. , Hollestelle Antoinette , Jager Agnes , Tilanus-Linthorst Madeleine M.A. , Hall Per , Czene Kamila , Liu Jianjun , Li Jingmei , Cox Angela , Cross Simon S. , Brock Ian W. , Reed Malcolm W.R. , Pharoah Paul , Blows Fiona M. , Dunning Alison M. , Ghoussaini Maya , Ashworth Alan , Swerdlow Anthony , Jones Michael , Schoemaker Minouk , Easton Douglas F. , Humphreys Manjeet , Wang Qin , Peto Julian , dos-Santos-Silva Isabel
Published: March 2023

PDF file, 57K, Genotyping characteristics of each BCAC participating study.
Supplementary Table 2 from Association between Lifestyle Factors and CpG Island Methylation in a Cancer-Free Population
Authors: Brait Mariana , Ford Jean G. , Papaiahgari Srinivas , Garza Mary A. , Lee Jin I. , Loyo Myriam , Maldonado Leonel , Begum Shahnaz , McCaffrey Lee , Howerton Mollie , Sidransky David , Emerson Mark R. , Ahmed Saifuddin , Williams Carla D. , Hoque Mohammad Obaidul
Published: March 2023

Supplementary Table 2 from Association between Lifestyle Factors and CpG Island Methylation in a Cancer-Free Population
Supplementary Table 1 from Association between Lifestyle Factors and CpG Island Methylation in a Cancer-Free Population
Authors: Brait Mariana , Ford Jean G. , Papaiahgari Srinivas , Garza Mary A. , Lee Jin I. , Loyo Myriam , Maldonado Leonel , Begum Shahnaz , McCaffrey Lee , Howerton Mollie , Sidransky David , Emerson Mark R. , Ahmed Saifuddin , Williams Carla D. , Hoque Mohammad Obaidul
Published: March 2023

Supplementary Table 1 from Association between Lifestyle Factors and CpG Island Methylation in a Cancer-Free Population
Supplementary Table 3 from Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) Polymorphism on Outcome of Advanced-Stage Squamous Cell Carcinoma of the Head and Neck Are Treatment Dependent
Authors: Zhong Shilong , Nukui Tomoko , Buch Shama , Diergaarde Brenda , Weissfeld Lisa A. , Grandis Jennifer , Romkes Marjorie , Weissfeld Joel L.
Published: March 2023

PDF file - 45K, Tumor characteristics according to ERCC2 genotype and CCND1 genotype.
Supplementary Table 1 from Effects of ERCC2 Lys751Gln (A35931C) and CCND1 (G870A) Polymorphism on Outcome of Advanced-Stage Squamous Cell Carcinoma of the Head and Neck Are Treatment Dependent
Authors: Zhong Shilong , Nukui Tomoko , Buch Shama , Diergaarde Brenda , Weissfeld Lisa A. , Grandis Jennifer , Romkes Marjorie , Weissfeld Joel L.
Published: March 2023

PDF file - 57K, A comparison of head and neck cancer cases included and excluded from analysis. Parentheses show numbers missing attribute data.
Supplementary Figure Legend for Figure 2 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies
Authors: Bolton Kelly L. , Garcia-Closas Montserrat , Pfeiffer Ruth M. , Duggan Máire A. , Howat William J. , Hewitt Stephen M. , Yang Xiaohong R. , Cornelison Robert , Anzick Sarah L. , Meltzer Paul , Davis Sean , Lenz Petra , Figueroa Jonine D. , Pharoah Paul D.P. , Sherman Mark E.
Published: March 2023

Supplementary Figure Legend for Figure 2 from Assessment of Automated Image Analysis of Breast Cancer Tissue Microarrays for Epidemiologic Studies
Supplementary Table 1 from External Validation of a Multiplex Urinary Protein Panel for the Detection of Bladder Cancer in a Multicenter Cohort
Authors: Chen Li-Mei , Chang Myron , Dai Yunfeng , Chai Karl X. , Dyrskjøt Lars , Sanchez-Carbayo Marta , Szarvas Tibor , Zwarthoff Ellen C. , Lokeshwar Vinata , Jeronimo Carmen , Parker Alexander S. , Ross Shanti , Borre Michael , Ørntoft Torben F. , Jaeger Tobias , Beukers Willemien , Lopez Luis E. , Henrique Rui , Young Paul R. , Urquidi Virginia , Goodison Steve , Rosser Charles J.
Published: March 2023

XLSX file - 12K, Summary of cubic-root transformed^ biomarker data by institute.
Supplementary Table Legends from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2
Authors: Prokunina-Olsson Ludmila , Fu Yi-Ping , Tang Wei , Jacobs Kevin B. , Hayes Richard B. , Kraft Peter , Berndt Sonja I. , Wacholder Sholom , Yu Kai , Hutchinson Amy , Spencer Feigelson Heather , Thun Michael J. , Diver W. Ryan , Albanes Demetrius , Virtamo Jarmo , Weinstein Stephanie , Schumacher Fredrick R. , Cancel-Tassin Geraldine , Cussenot Olivier , Valeri Antoine , Andriole Gerald L. , Crawford E. David , Haiman Christopher A. , Henderson Brian E. , Kolonel Laurence , Le Marchand Loic , Siddiq Afshan , Riboli Elio , Travis Ruth , Kaaks Rudolf , Isaacs William B. , Isaacs Sarah D. , Grönberg Henrik , Wiklund Fredrik , Xu Jianfeng , Vatten Lars J. , Hveem Kristian , Kumle Merethe , Tucker Margaret , Hoover Robert N. , Fraumeni Joseph F. , Hunter David J. , Thomas Gilles , Chatterjee Nilanjan , Chanock Stephen J. , Yeager Meredith
Published: March 2023

Supplementary Table Legends from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2
Supplementary Table 1 from A Candidate Gene Study of Folate-Associated One Carbon Metabolism Genes and Colorectal Cancer Risk
Authors: Levine A. Joan , Figueiredo Jane C. , Lee Won , Conti David V. , Kennedy Kathleen , Duggan David J. , Poynter Jenny N. , Campbell Peter T. , Newcomb Polly , Martinez Maria Elena , Hopper John L. , Le Marchand Loic , Baron John A. , Limburg Paul J. , Ulrich Cornelia M. , Haile Robert W.
Published: March 2023

Supplementary Table 1 from A Candidate Gene Study of Folate-Associated One Carbon Metabolism Genes and Colorectal Cancer Risk
Supplementary Table 2B from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2
Authors: Prokunina-Olsson Ludmila , Fu Yi-Ping , Tang Wei , Jacobs Kevin B. , Hayes Richard B. , Kraft Peter , Berndt Sonja I. , Wacholder Sholom , Yu Kai , Hutchinson Amy , Spencer Feigelson Heather , Thun Michael J. , Diver W. Ryan , Albanes Demetrius , Virtamo Jarmo , Weinstein Stephanie , Schumacher Fredrick R. , Cancel-Tassin Geraldine , Cussenot Olivier , Valeri Antoine , Andriole Gerald L. , Crawford E. David , Haiman Christopher A. , Henderson Brian E. , Kolonel Laurence , Le Marchand Loic , Siddiq Afshan , Riboli Elio , Travis Ruth , Kaaks Rudolf , Isaacs William B. , Isaacs Sarah D. , Grönberg Henrik , Wiklund Fredrik , Xu Jianfeng , Vatten Lars J. , Hveem Kristian , Kumle Merethe , Tucker Margaret , Hoover Robert N. , Fraumeni Joseph F. , Hunter David J. , Thomas Gilles , Chatterjee Nilanjan , Chanock Stephen J. , Yeager Meredith
Published: March 2023

Supplementary Table 2B from Refining the Prostate Cancer Genetic Association within the JAZF1 Gene on Chromosome 7p15.2
Supplementary Table 2 from An Admixture Scan in 1,484 African American Women with Breast Cancer
Authors: Fejerman Laura , Haiman Christopher A. , Reich David , Tandon Arti , Deo Rahul C. , John Esther M. , Ingles Sue A. , Ambrosone Christine B. , Bovbjerg Dana Howard , Jandorf Lina H. , Davis Warren , Ciupak Gregory , Whittemore Alice S. , Press Michael F. , Ursin Giske , Bernstein Leslie , Huntsman Scott , Henderson Brian E. , Ziv Elad , Freedman Matthew L.
Published: March 2023

Supplementary Table 2 from An Admixture Scan in 1,484 African American Women with Breast Cancer
Supplementary Tables 1-5 from Plasma Biomarker Profiles Differ Depending on Breast Cancer Subtype but RANTES Is Consistently Increased
Authors: Gonzalez Rachel M. , Daly Don S. , Tan Ruimin , Marks Jeffrey R. , Zangar Richard C.
Published: March 2023

Supplementary Tables 1-5 from Plasma Biomarker Profiles Differ Depending on Breast Cancer Subtype but RANTES Is Consistently Increased
Supplementary Table 2 from High Visfatin Expression in Breast Cancer Tissue Is Associated with Poor Survival
Authors: Lee Yi-Chen , Yang Yi-Hsin , Su Jinu-Huang , Chang Hsueh-Ling , Hou Ming-Feng , Yuan Shyng-Shiou F.
Published: March 2023

PDF file - 44K
Supplementary Table 1 from High Visfatin Expression in Breast Cancer Tissue Is Associated with Poor Survival
Authors: Lee Yi-Chen , Yang Yi-Hsin , Su Jinu-Huang , Chang Hsueh-Ling , Hou Ming-Feng , Yuan Shyng-Shiou F.
Published: March 2023

PDF file - 109K
Supplementary Tables 1-3 from Incident Cervical HPV Infections in Young Women: Transition Probabilities for CIN and Infection Clearance
Authors: Insinga Ralph P. , Perez Gonzalo , Wheeler Cosette M. , Koutsky Laura A. , Garland Suzanne M. , Leodolter Sepp , Joura Elmar A. , Ferris Daron G. , Steben Marc , Hernandez-Avila Mauricio , Brown Darron R. , Elbasha Elamin , Muñoz Nubia , Paavonen Jorma , Haupt Richard M.
Published: March 2023

Table 1A. 12, 24 and 36 month transition probabilities for incident HPV 16, 18, 31, 33, 35, 45, 52, 58 and 59 infections without adjudication of CIN lesions positive for multiple HPV types. Table 1B. 12 and 24 month transition probabilities for incident HPV 16, 18, 31, 45, 52 and 58 infected CIN 1 lesions without adjudication of CIN lesions positive for multiple HPV types. Table 2A. Prevalence of HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59 infections in CIN 1, CIN 2 and CIN 3 lesions (data derived from placebo arms of all Phase III trials)Table 2B. Prevalence of HPV 6, 11, 16, 18 with and without other tested HPV types* in CIN 1, CIN 2 and CIN 3 lesions (data derived from placebo arms of all Phase III trials). Table 3A. Distribution of HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59 in CIN 1, CIN 2 and CIN 3 lesions testing positive for a concordant HPV type as observed in a prior or concurrent incident HPV 16/18/31/33/35/45/52/58/59 infection. Table 3B. Distribution of HPV types 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58 and 59 in CIN 2 and CIN 3 lesions testing positive for a concordant HPV type as observed in a prior incident HPV 16/18/31/33/35/45/52/58/59 infected CIN 1 lesion.
Data from Reduced Plasma Level of CXC Chemokine Ligand 7 in Patients with Pancreatic Cancer
Authors: Matsubara Junichi , Honda Kazufumi , Ono Masaya , Tanaka Yoshinori , Kobayashi Michimoto , Jung Giman , Yanagisawa Koji , Sakuma Tomohiro , Nakamori Shoji , Sata Naohiro , Nagai Hideo , Ioka Tatsuya , Okusaka Takuji , Kosuge Tomoo , Tsuchida Akihiko , Shimahara Masashi , Yasunami Yohichi , Chiba Tsutomu , Hirohashi Setsuo , Yamada Tesshi
Published: March 2023

Abstract
Background: Early detection is essential to improve the outcome of patients with pancreatic cancer. A noninvasive and cost-effective diagnostic test using plasma/serum biomarkers would facilitate the detection of pancreatic cancer at the early stage.

Methods: Using a novel combination of hollow fiber membrane–based low-molecular-weight protein enrichment and LC-MS-based quantitative shotgun proteomics, we compared the plasma proteome between 24 patients with pancreatic cancer and 21 healthy controls (training cohort). An identified biomarker candidate was then subjected to a large blinded independent validation (n = 237, validation cohort) using a high-density reverse-phase protein microarray.

Results: Among a total of 53,009 MS peaks, we identified a peptide derived from CXC chemokine ligand 7 (CXCL7) that was significantly reduced in pancreatic cancer patients, showing an area under curve (AUC) value of 0.84 and a P value of 0.00005 (Mann–Whitney U test). Reduction of the CXCL7 protein was consistently observed in pancreatic cancer patients including those with stage I and II disease in the validation cohort (P < 0.0001). The plasma level of CXCL7 was independent from that of CA19-9 (Pearson's r = 0.289), and combination with CXCL7 significantly improved the AUC value of CA19-9 to 0.961 (P = 0.002).

Conclusions: We identified a significant decrease of the plasma CXCL7 level in patients with pancreatic cancer, and combination of CA19-9 with CXCL7 improved the discriminatory power of the former for pancreatic cancer.

Impact: The present findings may provide a new diagnostic option for pancreatic cancer and facilitate early detection of the disease. Cancer Epidemiol Biomarkers Prev; 20(1); 160–71. ©2011 AACR.
Data from Prevalence and Correlates of Smoking and Cessation-Related Behavior among Survivors of Ten Cancers: Findings from a Nationwide Survey Nine Years after Diagnosis
Authors: Westmaas J. Lee , Alcaraz Kassandra I. , Berg Carla J. , Stein Kevin D.
Published: March 2023

Abstract
Background: Smoking is detrimental to recovery and survival from cancer, but many cancer survivors continue to smoke. Information is lacking on smoking patterns of survivors many years after diagnosis and correlates of smoking status and patterns, likelihood of quitting, and intentions to quit.

Methods: Cross-sectional analyses were conducted among survivors of 10 cancers recruited by stratified random sampling from cancer registries in a nationwide, longitudinal, quality-of-life study (n = 2,938).

Results: Approximately 9 years after diagnosis, 9.3% of all survivors were current (past 30-day) smokers. Smoking prevalence was highest among survivors of bladder (17.2%), lung (14.9%), and ovarian (11.6%) cancers. Most current smokers (83%) smoked daily, averaging 14.7 cigarettes per day (cpd). Forty percent of daily smokers smoked more than 15 cpd. Nondaily smokers smoked a mean of 10.9 days in the last 30 days and averaged 5.7 cpd on smoking days. Current smoking was associated with younger age, lower education and income, and greater alcohol consumption. Quitting after diagnosis was associated with having a smoking-related cancer. Roughly, a third of current smokers intended to quit, 40% within the next month. The odds of intending to quit were lower if survivors were married, older, or smoked more.

Conclusions: This population-based study indicated that smoking can persist long after initial diagnosis and at high levels and identified characteristics associated with quitting and intentions to quit.

Impact: Findings can be used to identify survivors most at risk for continued smoking and to inform tailoring of cessation treatments for survivors. Cancer Epidemiol Biomarkers Prev; 23(9); 1783–92. ©2014 AACR.
Data from Low to Moderate Alcohol Intake Is Not Associated with Increased Mortality after Breast Cancer
Authors: Flatt Shirley W. , Thomson Cynthia A. , Gold Ellen B. , Natarajan Loki , Rock Cheryl L. , Al-Delaimy Wael K. , Patterson Ruth E. , Saquib Nazmus , Caan Bette J. , Pierce John P.
Published: March 2023

Abstract
Background: Both alcohol consumption and obesity have been linked with breast cancer morbidity and mortality. An inverse association between alcohol intake and obesity suggests possible confounding between these variables (and perhaps other factors) with breast cancer outcomes.

Methods: Alcohol intake (beer, wine, spirits, and total) was examined in 3,088 women previously diagnosed and treated for breast cancer within an intervention trial that targeted vegetables, fiber, and fat but not alcohol or weight loss. Factors associated with baseline alcohol intake were included in Cox proportional hazards models for recurrence and mortality.

Results: Alcohol intake was significantly associated with higher education and physical activity levels. Neither light alcohol intake nor obesity was significantly associated with breast cancer recurrence, but moderate alcohol intake >300 g/mo was protective against all-cause mortality (hazard ratio, 0.69; 95% confidence intervals, 0.49-0.97) in a proportional hazards model adjusted for obesity. Obese women were 61% more likely to be nondrinkers than drinkers, and 76% more likely to be light drinkers than moderate/heavy drinkers. In nonobese women, alcohol intake >10 g/mo was associated with lower risk of all-cause mortality (hazard ratio, 0.68; 95% confidence intervals, 0.51-0.91).

Conclusion: Light alcohol intake, regardless of body weight, did not increase the risk of breast cancer recurrence or all-cause mortality in this cohort of middle-aged women previously diagnosed with breast cancer. Alcohol intake was associated with other favorable prognostic indicators, which may explain its apparent protective effect in nonobese women. Cancer Epidemiol Biomarkers Prev; 19(3); 681–8
Data from Identification of a Novel Biomarker, SEMA5A, for Non–Small Cell Lung Carcinoma in Nonsmoking Women
Authors: Lu Tzu-Pin , Tsai Mong-Hsun , Lee Jang-Ming , Hsu Chung-Ping , Chen Pei-Chun , Lin Chung-Wu , Shih Jin-Yuan , Yang Pan-Chyr , Hsiao Chuhsing Kate , Lai Liang-Chuan , Chuang Eric Y.
Published: March 2023

Abstract
Background: Although cigarette smoking is the major risk factor for lung cancer, only 7% of female lung cancer patients in Taiwan have a history of smoking. The genetic mechanisms of carcinogenesis in nonsmokers are unclear, but semaphorins have been suggested to play a role as lung tumor suppressors. This report is a comprehensive analysis of the molecular signature of nonsmoking female lung cancer patients in Taiwan, with a particular focus on the semaphorin gene family.

Methods: Sixty pairs of tumor and adjacent normal lung tissue specimens were analyzed by using Affymetrix U133plus2.0 expression arrays. Differentially expressed genes in tumor tissues were identified by a paired t test and validated by reverse transcriptase-PCR and immunohistochemistry. Functional analysis was conducted by using Ingenuity Pathway Analysis as well as gene set enrichment analysis and sigPathway algorithms. Kaplan-Meier survival analyses were used to evaluate the association of SEMA5A expression and clinical outcome.

Results: We identified 687 differentially expressed genes in non–small cell lung carcinoma (NSCLC). Many of these genes, most notably the semaphorin family, were participants in the axon guidance signaling pathway. The downregulation of SEMA5A in tumor tissue, both at the transcriptional and translational levels, was associated with poor survival among nonsmoking women with NSCLC.

Conclusions: In summary, several semaphorin gene family members were identified as potential therapeutic targets, and SEMA5A may be useful as a prognostic biomarker for NSCLC, which may also be gender specific in Taiwanese patients.

Impact: A novel biomarker for NSCLC is identified. Cancer Epidemiol Biomarkers Prev; 19(10); 2590–7. ©2010 AACR.
Data from Prediagnostic Total and High-Density Lipoprotein Cholesterol and Risk of Cancer
Authors: Ahn Jiyoung , Lim Unhee , Weinstein Stephanie J. , Schatzkin Arthur , Hayes Richard B. , Virtamo Jarmo , Albanes Demetrius
Published: March 2023

Abstract
Background: Circulating total cholesterol has been inversely associated with cancer risk; however, the role of reverse causation and the associations for high-density lipoprotein (HDL) cholesterol have not been fully characterized. We examined the relationship between serum total and HDL cholesterol and risk of overall and site-specific cancers among 29,093 men in the Alpha-Tocopherol, Beta-Carotene Cancer Prevention (ATBC) Study cohort.

Methods: Fasting serum total and HDL cholesterol were assayed at baseline, and 7,545 incident cancers were identified during up to 18 years of follow-up. Multivariable proportional hazards models were conducted to estimate relative risks (RR).

Results: Higher serum total cholesterol concentration was associated with decreased risk of cancer overall (RR for comparing high versus low quintile, 0.85; 95% confidence interval, 0.79-0.91; P trend <0.001; >276.7 versus <203.9 mg/dL), and the inverse association was particularly evident for cancers of the lung and liver. These associations were no longer significant, however, when cases diagnosed during the first 9 years of follow-up were excluded. Greater HDL cholesterol was also associated with decreased risk of cancer (RR for high versus low quintile, 0.89; 95% confidence interval, 0.83-0.97; P trend = 0.01; >55.3 versus <36.2 mg/dL). The inverse association of HDL cholesterol was evident for cancers of lung, prostate, liver, and the hematopoietic system, and the associations of HDL cholesterol with liver and lung cancers remained after excluding cases diagnosed within 12 years of study entry.

Conclusion: Our findings suggest that prior observations regarding serum total cholesterol and cancer are largely explained by reverse causation. Although chance and reverse causation may explain some of the inverse HDL associations, we cannot rule out some etiologic role for this lipid fraction. (Cancer Epidemiol Biomarkers Prev 2009;18(11):2814–21)
Data from Screening for Colorectal Cancer in a Safety-Net Health Care System: Access to Care Is Critical and Has Implications for Screening Policy
Authors: Gupta Samir , Tong Liyue , Allison James E. , Carter Elizabeth , Koch Mark , Rockey Don C. , Anderson Paula , Ahn Chul , Argenbright Keith , Skinner Celette Sugg
Published: March 2023

Abstract
Background: Data on the number of individuals eligible for screening, and rates of screening, are necessary to assess national colorectal cancer screening efforts. Such data are sparse for safety-net health systems.

Methods: A retrospective cohort study of individuals ages 50 to 75 served by a safety-net health system in Tarrant County, TX was conducted to determine (a) the size of the potential screen-eligible population ages 50 to 75, (b) the rate of screening over 5 years among individuals ages 54 to 75, and (c) the potential predictors of screening, including sex, race/ethnicity, insurance status, frequency of outpatient visits, and socioeconomic status.

Results: Of 28,708 potential screen-eligible individuals, 20,416 were ages 54 to 75 and analyzed for screening; 22.0% were screened within the preceding 5 years. Female gender, Hispanic ethnicity, ages 65 to 75, insurance status, and two or more outpatient visits were independently associated with screening. Access to care was an important factor: adjusted odds ratio, 2.57 (95% confidence interval, 2.23-2.98) for any insurance; adjusted odds ratio, 3.53 (95% confidence interval, 3.15-3.97) for two or more outpatient visits.

Conclusions: The screen-eligible population served by our safety-net health system was large, and the projected deficit in screen rates was substantial. Access to care was the dominant predictor of screening participation. If our results are replicable in similar health systems, the data suggest that screening guidelines and policy efforts must take into account the feasibility of proposed interventions. Strong advocacy for more resources for colorectal cancer screening interventions (including research into the best manner to provide screening for large populations) is needed. (Cancer Epidemiol Biomarkers Prev 2009;18(9):2373–9)
Data from Smoking and Selected DNA Repair Gene Polymorphisms in Controls: Systematic Review and Meta-Analysis
Authors: Hodgson M. Elizabeth , Poole Charles , Olshan Andrew F. , North Kari E. , Zeng Donglin , Millikan Robert C.
Published: March 2023

Abstract
Background: When the case-only study design is used to estimate statistical interaction between genetic (G) and environmental (E) exposures, G and E must be independent in the underlying population, or the case-only estimate of interaction (COR) will be biased. Few studies have examined the occurrence of G–E association in published control group data.

Methods: To examine the assumption of G–E independence in empirical data, we conducted a systematic review and meta-analysis of G–E associations in controls for frequently investigated DNA repair genes (XRCC1 Arg399Gln, Arg194Trp, or Arg280His, XPD Lys751Gln, and Asp312Asn, and XRCC3 Thr241Met), and smoking (ever/never smoking, current/not current smoker, smoking duration, smoking intensity, and pack-years).

Results: Across the 55 included studies, single nucleotide polymorphisms SNP-smoking associations in controls (ORz) were not reliably at the null value of 1.0 for any SNP-smoking combinations. Two G–E combinations were too heterogeneous for summary estimates: XRCC1 399 and ever-never smoking (N = 21), and XPD 751 and pack-years (N = 12). ORz ranges for these combinations were: [ORz (95% confidence interval (CI)] 0.7 (0.4, 1.2)–1.9 (1.2, 2.8) and 0.8 (0.5, 1.3)–2.3 (0.8, 6.1), respectively). Estimates for studies considered homogeneous (Cochran's Q P-value <0.10) varied 2- to 5-fold. No study characteristics were identified that could explain heterogeneity.

Conclusions: We recommend the independence assumption be evaluated in the population underlying any potential case-only study, rather than in a proxy control group(s) or pooled controls.

Impact: These results suggest that G–E association in controls may be population-specific. Increased access to control data would improve evaluation of the independence assumption. Cancer Epidemiol Biomarkers Prev; 19(12); 3055–86. ©2010 AACR.
Data from Are HIV-Infected Men Vulnerable to Prostate Cancer Treatment Disparities?
Authors: Murphy Adam B. , Bhatia Ramona , Martin Iman K. , Klein David A. , Hollowell Courtney M.P. , Nyame Yaw , Dielubanza Elodi , Achenbach Chad , Kittles Rick A.
Published: March 2023

Abstract
Background: HIV-infected (HIV+) men face cancer treatment disparities that impact outcome. Prostate cancer treatment and treatment appropriateness in HIV+ men are unknown.

Methods: We used electronic chart review to conduct a retrospective cohort study of 43 HIV+ cases with prostate cancer and 86 age- and race-matched HIV-uninfected (HIV−) controls with prostate cancer, ages 40 to 79 years, from 2001 to 2012. We defined treatment appropriateness using National Comprehensive Cancer Network guidelines and the Charlson comorbidity index (CCI) to estimate life expectancy.

Results: Median age was 59.5 years at prostate cancer diagnosis. Median CD4+ T-cell count was 459.5 cells/mm3, 95.3% received antiretroviral therapy, and 87.1% were virally suppressed. Radical prostatectomy was the primary treatment for 39.5% of HIV+ and 71.0% of HIV− men (P = 0.004). Only 16.3% of HIV+ versus 57.0% of HIV− men received open radical prostatectomy (P < 0.001). HIV+ men received more radiotherapy (25.6% vs. 16.3%, P = 0.13). HIV was negatively associated with open radical prostatectomy (OR = 0.03, P = 0.007), adjusting for insurance and CCI. No men were undertreated. Fewer HIV+ men received appropriate treatment (89.2% vs. 100%, P = 0.003), due to four overtreated HIV+ men. Excluding AIDS from the CCI still resulted in fewer HIV+ men receiving appropriate treatment (94.6% vs. 100%, P = 0.03).

Conclusion: Prostate cancer in HIV+ men is largely appropriately treated. Under- or overtreatment may occur from difficulties in life expectancy estimation. HIV+ men may receive more radiotherapy and fewer radical prostatectomies, specifically open radical prostatectomies.

Impact: Research on HIV/AIDS survival indices and etiologies and outcomes of this prostate cancer treatment disparity in HIV+ men are needed. Cancer Epidemiol Biomarkers Prev; 23(10); 2009–18. ©2014 AACR.
Data from Use of the Predictive Sugars Biomarker to Evaluate Self-Reported Total Sugars Intake in the Observing Protein and Energy Nutrition (OPEN) Study
Authors: Tasevska Nataša , Midthune Douglas , Potischman Nancy , Subar Amy F. , Cross Amanda J. , Bingham Sheila A. , Schatzkin Arthur , Kipnis Victor
Published: March 2023

Abstract
Background: A predictive biomarker for intake of total sugars was recently developed under controlled conditions. We used this biomarker to assess measurement error (ME) structure in self-reported intake of total sugars in free-living individuals.

Methods: The Observing Protein and Energy Nutrition (OPEN) study involved 484 participants aged 40 to 69 years. Diet was assessed using two administrations of a food frequency questionnaire (FFQ) and two nonconsecutive 24-hour dietary recalls (24HDR). Two 24-hour urine samples checked for completeness were analyzed on sucrose and fructose. We applied the biomarker calibrated in a feeding study to OPEN data to assess the ME structure and the attenuation factors (AF) for intakes of absolute total sugars and sugars density for the FFQ and 24HDR.

Results: The AFs for absolute sugars were similar for a single FFQ and 24HDR, but attenuation decreased with repeated 24HDRs. For sugars density, the AFs for FFQ (men: 0.39; women: 0.33) were greater than for single 24HDR (men: 0.30; women: 0.24), and similar to two 24HDRs (men: 0.41; women: 0.35). The attenuation associated with both instruments was greater in women than in men.

Conclusions: Both the FFQ and 24HDR were found to be biased; hence, incorporation of the sugars biomarker in calibration studies within the cohorts may be necessary to more reliably estimate associations of sugars and disease.

Impact: In this article, we propose a new dietary reference instrument based on the recently defined class of predictive biomarkers. Using sugars biomarker, we quantify ME in the FFQ- and 24HDR-reported absolute total sugars and total sugars density. Cancer Epidemiol Biomarkers Prev; 20(3); 490–500. ©2011 AACR.
Data from International Trends in Liver Cancer Incidence Rates
Authors: Center Melissa M. , Jemal Ahmedin
Published: March 2023

Abstract
Background: Several previous studies have documented region or country-specific liver cancer incidence trends around the world. However, no study has systematically examined the international pattern using the most recently updated incidence data from the International Agency for Research on Cancer.

Methods: We examined recent trends in liver cancer incidence rates from 1993 to 2002 by joinpoint analysis for 32 cancer registries worldwide, using Cancer Incidence in Five Continents. We also examined the male to female rate ratios for these and four additional registries, based on the 1998–2002 incidence data.

Results: Liver cancer incidence rates for both men and women statistically significantly increased from 1993 to 2002 for 8 of 32 cancer registries considered in the analysis. Increases were largely confined to economically developed countries of Western Europe, North America, and Oceania. In contrast, rates decreased in both men and women in 5 registries including 3 in Asia. Despite this, the incidence rates in Asian countries are twice as high as those in Africa and more than four times as high as rates in North America. Male to female rate ratios varied from 0.9 in sub-Saharan African and South American registries to 5.0 in France and Egypt.

Conclusions: Liver cancer incidence rates continue to increase in some low-risk parts of the world whereas they are decreasing in some of the highest risk countries in Asia. Etiologic studies are required to further elucidate factors contributing to the divergent liver cancer incidence trends worldwide.

Impact: Our description of international liver cancer incidence trends may stimulate further etiologic studies. Cancer Epidemiol Biomarkers Prev; 20(11); 2362–8. ©2011 AACR.
Data from Allergic Diseases and Risk of Hematopoietic Malignancies in a Cohort of Postmenopausal Women: A Report from the Iowa Women's Health Study
Authors: Linabery Amy M. , Prizment Anna E. , Anderson Kristin E. , Cerhan James R. , Poynter Jenny N. , Ross Julie A.
Published: March 2023

Abstract
Background: Allergic diseases signify immune dysregulation attributable to underlying genetics and environmental exposures. Associations between various allergies and hematopoietic cancers have been observed, albeit inconsistently; however, few prospective studies have examined the risk, and even fewer among older adults.

Methods: We examined risk of incident hematopoietic cancers in those reporting allergic diseases in a population-based cohort of 22,601 older women (Iowa Women's Health Study). Self-reported allergic status, including asthma, hay fever, eczema, and/or other allergies, was determined via questionnaire in 1997 (mean age, 72 years; range, 63–81 years). Incident cancers were ascertained by linkage with the Iowa Cancer Registry from 1997 to 2011. Cox proportional hazards regression was performed to estimate multivariate-adjusted HR and 95% confidence intervals (CI) for myeloid (N = 177) and lymphoid (N = 437) malignancies, respectively.

Results: Allergic diseases were not associated with risk of myeloid (HR, 1.00; 95% CI, 0.72–1.37) or lymphoid (HR, 0.99; 95% CI, 0.81–1.22) malignancies overall, or for most allergic and malignant subtypes examined. Self-reported asthma was positively associated with development of myelodysplastic syndrome (MDS; HR, 2.00; 95% CI, 0.93–4.32). In addition, there was a 30% to 40% decrease in risk of both lymphoid and myeloid cancers in those reporting rural residences but no association in those reporting urban residences; the interaction between residence and allergy was statistically significant for lymphoid malignancies (Pinteraction = 0.05).

Conclusions and Impact: These results suggest that asthma may contribute to the pathogenesis of MDS, a finding consistent with the chronic antigen stimulation hypothesis. Susceptibility differences by location of residence are concordant with the hygiene hypothesis and merit additional exploration. Cancer Epidemiol Biomarkers Prev; 23(9); 1903–12. ©2014 AACR.