bluuebunny/crossref_metadata_2025 huggingface dataset:
Factores de riesgo encontrados en rechazo de material de osteosíntesis
Authors: Lázaro Galdámez Carlos José
Published: August 2024

PROBLEMA: La identificación temprana de los factores de riesgo que presentan los pacientes que son sometidos a una cirugía de osteosíntesis es de mucha importancia para un tratamiento oportuno. OBJETIVO: Describir los factores de riesgo encontrados en pacientes con rechazo de material de osteosíntesis ingresados en el Hospital de Chiquimula en los años enero, 2019 – diciembre, 2023. MÉTODO: Se realizó un estudio descriptivo retrospectivo, con una muestra de 148 expedientes clínicos de pacientes ingresados en los servicios de traumatología con diagnóstico de rechazo de material de osteosíntesis, a través de una boleta de recolección de datos, los cuales se analizaron y sintetizaron. RESULTADOS: Los factores de riesgo para rechazo de material de osteosíntesis encontrados en los expedientes clínicos estudiados son fracturas expuestas 60%, tabaquismo 45%, diabetes mellitus descompensada 40%, alcoholismo 30%, tiempo de encamamiento prolongado previo a procedimiento quirúrgico ortopédico 25%, artritis reumatoide 20% de la población estudiada. El grupo etario más frecuente en rechazo de material de osteosíntesis fue entre las edades de 35 a 44 años, en el 33% de los casos, predominando el sexo masculino en el 29%. Los procedimientos ortopédicos más frecuentes en pacientes con rechazo de material de osteosíntesis fueron osteosíntesis con placa 80%, artroplastias 15% y osteosíntesis con clavo endomedular 5%. CONCLUSIÓN: Los pacientes, al tener los factores de riesgo ya mencionados, aumentan su probabilidad de padecer complicaciones tardías como rechazo de material de osteosíntesis, por lo cual dicho estudio los da a conocer para tomarlos en cuenta y prevenirlos o controlarlos.
PENERAPAN MEDIA INTERAKTIF UNTUK MENINGKATKAN KEMAMPUAN BAHASA ANAK USIA DINI
Authors: NURHASANAH  , ATIKA AZZAROH  , BEBI APRIYANTI HIDAYAH  , HAFIDOH  , MARCELLA SULYSTIA AYU
Published: August 2024

Pembelajaran pada anak usia dini memerlukan media pembelajaran yang inovatif dan menyenangkan untuk mengembangkan kemampuan bahasa anak. Tujuan dari penelitian ini untuk meningkatkan kemampuan bahasa anak usia dini di Deli Serdang menggunakan media interaktif power point. Jenis penelitian ini adalah penelitian kualitatif deskriptif dengan pengumpulan data berupa observasi dan studi pustaka. Hasil penelitian, media interaktif memegang peranan yang cukup penting dalam proses pemberian stimulasi karena media ini dapat memperlancar pemahaman serta memperkuat ingatan  anak. Media interaktif menjadi salah satu jenis media yang banyak digunakan, bukan hanya memberikan informasi tentang pembelajaran namun dapat mengemasnya dengan unsur yang menghibur. Kebahasaan anak usia dini perlu dilatih dengan menggunakan berbagai cara, termasuk dengan menggunakan media pembelajaran yang kreatif dan inovatif. Dari permasalahan itu maka perlu adanya pengembangan media interaktif untuk membuat pelajaran lebih bervariasi yang akan membantu mengembangkan aspek bahasa anak usia dini, penggunaan media interaktif mampu meningkatkan motivasi belajar anak dan membuat suasana menyenangkan bagi anak. Guru sangat berperan penting dalam kemampuan berbahasa anak secara maksimal dengan memberikan stimulasi pada proses pembelajaran di sekolah. Peningkatan kemampuan berbicara anak usia dini di Deli Serdang terstimulasi melalui kegiatan bermain menggunakan media interaktif. Media yang digunakan menggunakan power point yang dapat digunakan secara fleksibel baik oleh guru maupun orangtua.
UPAYA GURU DALAM MENGEMBANGKAN KECERDASAN EKSTENSIAL PADA ANAK USIA DINI DI TK ALJARWAL GALANG
Authors: HILYATUL ULYA NAZWA AFIFAH  , JIHAN FADIYAH FITHRI SIREGAR  , MUTIARA AZAHRA BR.SINAGA  , MASGANTI SIT
Published: August 2024

Penelitian ini bertujuan untuk mengetahui informasi bagaimana cara guru dalam mengembangkan dan mengidentifikasi kecerdasan eksistensial pada anak usia dini di tk al jarwal  . Metode analisis data yang digunakan dalam penelitian ini adalah metode penelitian deskriptif kualitatif.Teknik pengumpulan data dilakukan dengan menggunakan metode observasi, wawancara, dan dokumentasi.Subjek yang digunakan adalah seluru anak - anak di TK AL - JARWAL.Hasil penelitian menunjukkan bahwa pengembangan kecerdasan ekstensial dilakukan dengan cara apa pun seperti bercerita, menyanyi, dan karyawisata yang melibatkan anak secara langsung.Cara ini sangat baik untuk pengembangan kecerdasan ekstensial sejak dini sangat berguna bagi kehidupan mereka saat ini, esok dan selamanya.
INCIDÊNCIA DA RETINOPATIA DA PREMATURIDADE ACOMPANHADA EM SERVIÇO DE SEGUIMENTO HOSPITALAR NO OESTE DO PARANÁ
Authors: TorettaI Ana Laura , Machado Roberto Augusto Fernandes
Published: August 2024

A retinopatia da prematuridade (ROP), uma doença neurovascular que se desenvolve nos olhos de recém-nascidos prematuros, é a principal causa de cegueira infantil prevenível na América Latina, sendo a prematuridade (<37 semanas) o principal fator de risco, além do baixo peso ao nascimento (<1500g). A formação da retina fetal se inicia por volta 16° semana de idade gestacional, sendo concluído entre a 36° e 40° semana de gestação. Objetivo: Avaliar a incidência de retinopatia da prematuridade em recém-nascidos prematuros, investigando a idade gestacional e peso ao nascer dos afetados, além de analisar a comorbidade mais prevalente e se apresenta predominancia pelo sexo. Métodos: Realizamos um estudo retrospectivo e analítico longitudinal, analisando os prontuários de pacientes diagnosticados com retinopatia da prematuridade de janeiro de 2020 a 1º de maio de 2024. Todos os dados foram coletados exclusivamente dos prontuários, sem contato direto com os pacientes, abrangendo todos os recém-nascidos prematuros no período mencionado. Resultados: o hospital registrou 942 hospitalizações de recém-nascidos prematuros na UTIN, dos quais 7 pacientes (0,74%) foram incluídos na amostra do estudo. Destes pacientes com ROP, 42,86% tinham idade gestacional (IG) inferior a 30 semanas e peso abaixo de 1.500g, enquanto 57,14% tinham IG entre 31 e 37 semanas e peso entre 1.501 e 2.000g. A maioria dos pacientes era do sexo feminino (85,71%). Com base na classificação da ROP, 42,86% dos casos apresentavam Zona 2 avascular e 57,14% Zona 3. Além disso, 71,43% dos pacientes apresentavam desconforto respiratório. Conclusão: Os dados confirmam que prematuridade extrema e baixo peso ao nascimento são riscos importantes para a Retinopatia da Prematuridade (ROP). A discrepância entre os sexos deve ser investigada mais a fundo. A prevalência de um baixo valor na escala de Apgar indica condições comprometidas no nascimento e ressalta a necessidade de documentação mais completa. A análise destaca a importância de uma vigilância rigorosa e estratégias de intervenção precoce para melhorar os resultados em recém-nascidos prematuros.
Eficácia da Telepsiquiatria no Tratamento de Transtornos de Ansiedade: Uma Revisão de Literatura
Authors: Ferreira Rhinow Laís , de Andrade Gomes Amanda , de Andrade Gomes Amanda , Cozac Roos Amanda , Soares de Pinho Maria Laura , dos Santos Vieira Luísa , Carvalho de Brito Michelle
Published: August 2024

A eficácia da telepsiquiatria no manejo dos transtornos de ansiedade representa uma área de interesse crescente na psiquiatria moderna. A análise das pesquisas mais recentes sugere que, embora as intervenções baseadas em telepsiquiatria, como a terapia cognitivo-comportamental (TCC) e a terapia de exposição através de videoconferência, sejam amplamente utilizadas e valorizadas por sua acessibilidade e conveniência, elas também enfrentam desafios específicos.
As respostas dos pacientes ao tratamento podem variar significativamente, especialmente em indivíduos com condições coexistentes, o que pode impactar a eficácia da telepsiquiatria. Isso destaca a necessidade de uma avaliação clínica criteriosa e de uma abordagem personalizada para cada paciente, considerando as particularidades dos transtornos de ansiedade e a natureza frequentemente imprevisível dessas condições.
Os estudos revisados indicam que a escolha das técnicas terapêuticas, a adaptação das intervenções para o formato online, e a compreensão das necessidades individuais dos pacientes são fundamentais para maximizar a eficácia do tratamento. Por exemplo, a TCC realizada por telepsiquiatria, embora eficaz em muitos casos, requer ajustes específicos para garantir que os pacientes recebam o suporte necessário, especialmente em termos de monitoramento de sintomas e adesão ao tratamento.
Além disso, a necessidade de um acompanhamento contínuo através de plataformas digitais sublinha a importância de protocolos rigorosos para garantir a qualidade e a segurança do atendimento. Estudos mostram que, mesmo após o término do tratamento, o acompanhamento contínuo é essencial para prevenir recaídas e monitorar o progresso do paciente, exigindo intervenções rápidas e eficazes, quando necessário.
Em conclusão, a literatura revisada ressalta a importância de um planejamento cuidadoso e uma avaliação médica detalhada antes de iniciar o tratamento de transtornos de ansiedade através de telepsiquiatria. A combinação de uma escolha cuidadosa das técnicas terapêuticas, adaptação adequada para o ambiente online, e um acompanhamento atento pode aumentar significativamente a eficácia do tratamento. À medida que a demanda por serviços de telepsiquiatria continua a crescer, é crucial que os profissionais de saúde estejam bem preparados para manejar os desafios específicos dessa modalidade de tratamento, garantindo a segurança e a melhoria na qualidade de vida dos pacientes.
Analisis Swot Implementasi Online Single Submission (Oss) Dalam Optimalisasi Investasi Di Kabupaten Tulungagung
Authors: Hanif Lisa Ariesta Nur Hanif
Published: August 2024

Dalam meningkatkan performa ekonomi digital, Online Single Submission (OSS) merupakan salah satu wujud dari reformasi ekonomi digital yang diciptakan pemerintah Indonesia. Penerapan OSS juga merupakan salah satu cara pemerintah dalam mewujudkan optimalisasi  investasi di Indonesia dengan cara penyederhanaan birokrasi administrasi untuk memberikan pelayanan publik yang berkualitas dan optimal. Dalam mewujudkan implementasiannya dalam masyarakat, pemerintah Indonesia memberikan komitmen agar pelayanan OSS ini bisa dilakukan dengan mudah, cepat dan tepat. Melihat Fenomena tersebut, penelitian ini ditujukan untuk mengetahui implementasi Online Single Submission dalam mewujudkan optimalisasi Investasi di DPMPTSP Kabupaten Tulungagung dengan pendekatan deskriptif kualitatif dan metode analisis Swot bertujuan untuk menganalisis kekuatan (Strengths), kelemahan (Weaknesses), peluang (Opportunities), dan ancaman (Threats) dari implementasi Sistem Online Single Submission (OSS) dalam upaya optimalisasi investasi di Kabupaten Tulungagung. Melalui pendekatan kualitatif, penelitian ini memeriksa persepsi dan pengalaman pemangku kepentingan serta faktor-faktor kunci yang mempengaruhi keberhasilan atau kegagalan penerapan OSS.
Pengembangan Desa Wisata Berbasis Agropolitan
Authors: Irianto Heru , Nurany Fierda
Published: August 2024

The development of agropolitan-based tourism villages emerged as an innovation that responds to problems related to social and economic challenges in rural communities. This dynamic involves a number of factors, including increasing awareness of the importance of environmental preservation and sustainability. Villages that are largely dependent on agriculture often face economic constraints, especially with limited economic diversification in the region. As a solution, the agropolitan-based tourism village concept integrates tourism and the agribusiness sector to stimulate local economic growth. The purpose of this study was to determine the development of agropolitan-based tourism villages in Wonosalam and the factors that hinder the development of agropolitan villages. This research method uses qualitative methods with SWOT analysis. The results of this study show that the importance of rural economic development through the agribusiness sector is a key element in agropolitan area policy. Support from the government and relevant institutions is an important factor to ensure the successful implementation of this policy, both in the form of financial assistance and policies that support the growth of the agribusiness sector. The success of agropolitan-based tourism villages in Wonosalam is not only related to economic growth, but also to the preservation of local culture and traditions. The success of agropolitan villages in Wonosalam involves optimizing internal strengths and mitigating weaknesses, by overcoming dependence on the agricultural sector through economic diversification. Dependence on government support needs to be balanced with strengthening local capacity so that agropolitan villages are more independent
A Analisa Studi Kasus Penerapan Terapi Wicara AIUEO Pada Pasien Stroke Dengan Gangguan Bicara
Authors: Husni Husni
Published: August 2024

Stroke tetap menjadi masalah kesehatan global yang serius yang seringkali menyebabkan gangguan berbicara yang signifikan, mempengaruhi interaksi sehari-hari dan kualitas hidup pasien. Penelitian ini bertujuan untuk menginvestigasi karakteristik pasien stroke, termasuk usia, jenis kelamin, tingkat pendidikan, riwayat medis keluarga, jenis stroke, dan frekuensi serangan stroke. Fokusnya adalah mengevaluasi kemampuan berbicara pasien sebelum dan setelah terapi bicara AIUEO serta menilai efektivitas terapi tersebut dalam meningkatkan kemampuan berbicara. Studi deskriptif ini menggunakan pendekatan studi kasus melalui satu subjek pasien stroke dengan gangguan berbicara, difokuskan pada penerapan terapi bicara AIUEO serta penilaian ekspresi, interaksi, dan pemahaman bahasa. Setelah dilakukan terapi bicara AIUEO selama tujuh hari, terjadi peningkatan signifikan dalam kemampuan berbicara pasien stroke, ditunjukkan oleh kenaikan skor Functional Communication Scale (Derby) dari 9 sebelum terapi menjadi 14 setelah terapi. Terapi bicara AIUEO terbukti efektif dalam meningkatkan kemampuan berbicara pasien stroke, mengonfirmasi nilai potensialnya dalam program rehabilitasi yang bertujuan untuk meningkatkan keterampilan komunikasi dan kualitas hidup secara menyeluruh. Studi ini mengusulkan bahwa terapi AIUEO dapat diintegrasikan ke dalam protokol perawatan standar untuk pasien stroke, memberikan manfaat jangka panjang terkait dengan hasil komunikasi dan peningkatan kualitas hidup.
Preditores de Terapias Apropriadas e Óbito em Pacientes com Cardiodesfibrilador Implantável e Cardiopatia Chagásica Crônica
Authors: Pereira Francisca Tatiana Moreira , Rocha Eduardo Arrais , Gondim Davi Sales Pereira , Almeida Rosa Livia Freitas de , Pires Neto Roberto da Justa
Published: August 2024

Resumo Fundamento: Existem poucos estudos retrospectivos e prospectivos sobre cardiodesfibrilador implantável (CDI) na prevenção primária e secundária de morte súbita na cardiopatia chagásica crônica (CCC). Objetivos: Descrever a evolução a longo prazo dos portadores de CCC com CDI e identificar e analisar os preditores de mortalidade e de terapia apropriada do dispositivo nessa população. Métodos: Trata-se de um estudo prospectivo histórico com 117 pacientes portadores de CDI e CCC. Dispositivos foram implantados de janeiro de 2003 a dezembro de 2021. Fatores preditores de terapias apropriadas e mortalidade a longo prazo foram identificados e analisados. O nível de significância estatística é de p < 0,05. Resultados: Pacientes (n = 117) tiveram mediana de seguimento de 61 meses (25 a 121 meses), sendo o gênero masculino (74%) predominante e a mediana de idade de 55 anos (48 a 64 anos). Houve 43,6% de choques apropriados, 26,5% de estimulação cardíaca antitaquicardia (ATP) e 51% de terapias apropriadas. Durante o seguimento, 46 pacientes (39,7%) foram a óbito. A mortalidade foi de 6,2% pessoas-ano (intervalo de confiança [IC] 95%: 4,6 a 8,3), com 2 mortes súbitas durante o seguimento. A prevenção secundária (hazard ratio [HR] 2.1; IC 95%: 1,1 a 4,3; p = 0,029) e a fração de ejeção menor que 30% (HR 1.8; IC 95%: 1,1 a 3,1; p < 0,05) foram preditores de terapias apropriadas. Escore de Rassi intermediário apresentou uma forte associação com ocorrência de ATP isoladamente (p = 0,015). A classe funcional IV (p = 0,007), fração de ejeção do ventrículo esquerdo < 30 (p = 0,010) e a idade maior que 75 anos (p = 0,042) foram preditores de mortalidade total. Conclusão: Os desfibriladores na CCC apresentaram elevada incidência de acionamento apropriado especialmente naqueles pacientes de prevenção secundária, fração de ejeção do ventrículo esquerdo baixa e escore de Rassi intermediário. Os pacientes com insuficiência cardíaca congestiva, classe funcional avançada e idade maior que 75 anos apresentaram elevada mortalidade.
Predictors of Appropriate Therapies and Death in Patients with Implantable Cardioverter-Defibrillator and Chronic Chagas Heart Disease
Authors: Pereira Francisca Tatiana Moreira , Rocha Eduardo Arrais , Gondim Davi Sales Pereira , Almeida Rosa Livia Freitas de , Pires Neto Roberto da Justa
Published: August 2024

Abstract Background: There are few retrospective and prospective studies on implantable cardioverter-defibrillators (ICD) in primary and secondary prevention of sudden death in chronic Chagas heart disease (CCHD). Objectives: To describe the long-term evolution of patients with CCHD and ICD and to identify and analyze predictors of mortality and appropriate device therapy in this population. Methods: This was a historical prospective study with 117 patients with ICD and CCHD. Devices were implanted from January 2003 to December 2021. Predictors of appropriate therapies and long-term mortality were identified and analyzed. The level of statistical significance was p < 0.05. Results: Patients (n = 117) had a median follow-up of 61 months (25 to 121 months); they were predominantly male (74%), with a median age of 55 years (48 to 64 years). There were 43.6% appropriate shocks, 26.5% antitachycardia pacing (ATP), and 51% appropriate therapies. During follow-up, 46 patients (39.7%) died. Mortality was 6.2% person-years (95% confidence interval [CI]: 4.6 to 8.3), with 2 sudden deaths during follow-up. Secondary prevention (hazard ratio [HR] 2.1; 95% CI: 1.1 to 4.3; p = 0.029) and ejection fraction less than 30% (HR 1.8; 95% CI: 1.1 to 3.1; p < 0.05) were predictors of appropriate therapies. Intermediate Rassi score showed a strong association with the occurrence of ATP alone (p = 0.015). Functional class IV (p = 0.007), left ventricular ejection fraction < 30 (p = 0.010), and age above 75 years (p = 0.042) were predictors of total mortality. Conclusion: ICDs in CCHD showed a high incidence of appropriate activation, especially in patients with secondary prevention, low left ventricular ejection fraction, and intermediate Rassi score. Patients with congestive heart failure, elevated functional class, and age over 75 years showed elevated mortality.
Randomized Study Comparing Radiofrequency Ablation with the PVAC Gold System vs. Antiarrhythmic Drugs in Elderly Patients with Symptomatic Atrial Fibrillation
Authors: Martins Luiz Claudio Berhmann , Pisani Cristiano F. , Dorfman Fabio K. , Darrieux Francisco C. C. , Wu Tan C. , Ferraz Alberto P. , Hachul Denise T. , Castro Claudio Campi de , Prado Rogério Ruscitto do , Souza Luciana V. F. , Sacilloto Luciana , Pessente Gabrielle D. A. , Grupi Cesar J. , Chokr Muhieddine Omar , Nomura Cesar H. , Oliveira Kátia Rodrigues de , Balbo Conrado P. , Melo Sissy L. , Veronese Pedro , Scanavacca Mauricio I.
Published: August 2024

Abstract Background There are no randomized studies comparing the maintenance of sinus rhythm after catheter ablation (CA) concerning treatment with antiarrhythmic drugs (AA) in elderly patients with paroxysmal atrial fibrillation (AF). Objectives To compare the clinical results of pulmonary vein (PV) isolation with the second-generation PVAC Gold catheter against AA treatment in elderly people with recurrent symptomatic paroxysmal AF, refractory to at least one AA, and without structural heart disease. Methods Sixty patients with paroxysmal AF ≥ 65 years old were randomized to two forms of treatment: group 1: CA and group 2: AA drugs. The primary outcome was the AF recurrence-free rate after at least one year of follow-up. Secondary outcomes were: progression to persistent forms of AF, impact on quality of life (QOLF), and complications. The significance level adopted in the statistical analysis was 5% (p<0.05). Results The AF recurrence-free rate was 80% (10% with amiodarone) in the CA group, after 1.3 procedures per patient and 65% in the AA group (60% with amiodarone), (p = 0.119) in an average follow-up of 719 days (Q1: 566; Q3: 730). The persistent AF free rate was 83.4% in the AC group and 67.7% in the AA group (p = 0.073) Both strategies showed an improvement in the AFQoL score during follow-up (p < 0.001), with no difference between the groups. Although without clinical repercussions or impact on the intellectual assessment test, 25% of patients in the CA group showed signs of cerebral embolization on brain MRI. Conclusions Both strategies for maintaining sinus rhythm promoted an improvement in the quality of life of elderly patients with symptomatic AF, with no statistical difference in the clinical outcomes. Additional studies using technologies with a better safety profile are needed to evaluate the benefits of CA in elderly patients with AF.
Atividade Física no Tempo Livre e Incidência de Hipertensão Arterial em Participantes do ELSA-Brasil
Authors: Souza Tarcísio C. , Matos Sheila M. A. , Almeida Maria da C. C. de , Fonseca Maria J. M. , Molina Maria del Carmen B. , Griep Rosane H. , Pitanga Cristiano P. S. , Pitanga Francisco J. G.
Published: August 2024

Resumo Fundamento: Evidências apontam que a atividade física (AF) apresenta efeito protetor para as doenças crônicas, incluindo a hipertensão arterial (HA). Objetivo: Este estudo investigou, de forma longitudinal, a associação entre as mudanças na atividade física no tempo livre (AFTL) e a incidência de HA em participantes do ELSA-Brasil. Métodos: Foram analisados dados de 8.968 participantes em dois momentos distintos (2008-2010 e 2012-2014). Foi utilizado o Questionário Internacional de Atividade Física (IPAQ), versão longa, para avaliação da AFTL. A associação entre AFTL e HA foi testada por regressão de Poisson com estimativa do risco relativo (RR), com nível de significância de 5% e intervalo de confiança de 95%. Resultados: Quando a variável nível de AFTL foi categorizada em suficiente e insuficiente, não foram encontradas associações estatisticamente significantes entre AFTL e a incidência HA em função das mudanças na AF durante o seguimento. No entanto, a variável AFTL quando categorizada em inativo, pouco ativo, ativo e muito ativo, observou-se associação estatisticamente significante entre AFTL e HA em participantes classificados como muito ativos fisicamente. O risco de HA foi reduzido em 35% entre homens RR 0,65 (IC 95% 0,50-0,86) e em 66% entre as mulheres RR 0,34 (IC 95% 0,20-0,58) que mantiveram altos níveis de AFTL em ambos os momentos do seguimento. Conclusão: Esses resultados sugerem que a manutenção de altos níveis de AF ao longo do tempo está associada a um menor risco de desenvolver HA, destacando a importância da AF na prevenção dessa condição, tanto para homens quanto para mulheres.
Leisure Time Physical Activity and Incidence of Arterial Hypertension in ELSA-Brasil Participants
Authors: Souza Tarcísio C. , Matos Sheila M. A. , Almeida Maria da C. C. de , Fonseca Maria J. M. , Molina Maria del Carmen B. , Griep Rosane H. , Pitanga Cristiano P. S. , Pitanga Francisco J. G.
Published: August 2024

Abstract Background: Evidence indicates that physical activity (PA) has a protective effect against chronic diseases, including high arterial hypertension (AH). Objective: This study investigated, longitudinally, the association between changes in leisure time physical activity (LTPA) and the incidence of hypertension in ELSA-Brasil participants. Methods: Data from 8,968 participants were analyzed at two different times (2008-2010 and 2012-2014). The International Physical Activity Questionnaire (IPAQ), long version, was used to assess LTPA. The association between LTPA and AH was tested using Poisson regression with relative risk (RR) estimation, with a significance level of 5% and a 95% confidence interval. Results: When the LTPA level variable was categorized as sufficient and insufficient, no statistically significant associations were found between LTPA and AH incidence as a function of changes in PA during follow-up. However, when the LTPA variable was categorized as inactive, little active, active, and very active, a statistically significant association was observed between LTPA and AH in participants classified as very physically active. The risk of AH was reduced by 35% among men RR 0.65 (95% CI 0.50-0.86) and by 66% among women RR 0.34 (95% CI 0.20-0.58) who maintained high levels of LTPA at both moments of follow-up. Conclusion: These results suggest that maintaining high levels of PA over time is associated with a lower risk of developing AH, highlighting the importance of PA in preventing this condition, for both men and women.
Enhancing DNA Sequencing Workflow with AI-Driven Analytics
Authors: Aravind Ayyagiri  , Anshika Aggarwal  , Shalu Jain
Published: August 2024

The rapid advancements in DNA sequencing technologies have revolutionized genomics, enabling a deeper understanding of genetic information and its implications in various fields such as medicine, agriculture, and evolutionary biology. However, the exponential increase in sequencing data presents significant challenges in terms of data management, analysis, and interpretation. Traditional methods often fall short in handling the complexity and volume of data generated, necessitating the integration of advanced technologies like Artificial Intelligence (AI) to optimize the DNA sequencing workflow.
AI-driven analytics offer transformative potential in enhancing DNA sequencing workflows by automating data processing, improving accuracy, and accelerating the pace of discovery. This abstract explores how AI can be integrated into various stages of the DNA sequencing process, including data preprocessing, alignment, variant calling, and downstream analysis. The integration of AI algorithms, such as machine learning and deep learning models, can streamline these processes by reducing manual intervention and minimizing errors. For instance, AI can enhance base calling accuracy, identify rare variants, and predict phenotypic outcomes with higher precision than traditional methods.
The AI-driven approach in DNA sequencing is particularly beneficial in handling the challenges posed by next-generation sequencing (NGS) technologies. These technologies generate massive amounts of data that require efficient processing and interpretation. AI algorithms can be trained on large datasets to recognize patterns and anomalies that may be overlooked by human analysts. This capability is crucial in identifying novel mutations, understanding complex gene interactions, and drawing meaningful conclusions from vast genomic datasets.
ISSUES OF LEGISLATIVE SUPPORT AND THEORETICAL SUBSTANTIATIONS FOR MANAGEMENT DECISIONS IN NATURAL MONOPOLY SPHERES
Authors:   Federal Research Center “Computer Science and Control” Russian Academy of Sciences, Moscow, Russia, Belousova Nataliya I.
Published: August 2024

Particular aspects of Russian legislation on natural monopolies are researched with due regard to theoretical substantiations and take into account the current unification of natural monopoly regulation. The research methodology encompasses different modern natural monopoly theory approaches, legislative regulation in the spheres under consideration in the context of relevant structural reforming, as well as theoretical and applied systems analysis of infrastructure subsystems.
LABOR PRODUCTIVITY AS A KEY FACTOR IN IMPROVING OPERATIONAL EFFICIENCY IN RUSSIAN ENGINEERING
Authors:   independent researcher, Moscow, Russia, Lisovskaya Ekaterina G. , Baluyev Vladislav I. ,   Moscow State University of Technology «STANKIN», Moscow, Russia, Eleneva Yuliya Ya. ,   Moscow State University of Technology «STANKIN», Moscow, Russia
Published: August 2024

The article addresses the critical challenges and solutions for improving labor productivity in the Russian mechanical engineering sector. The primary issues include outdated equipment, insufficient investment, and demographic challenges such as workforce aging. The study emphasizes the importance of modernizing production facilities, integrating advanced technologies like automation and digitalization, and enhancing workforce skills through continuous training. Additionally, it highlights the sensitivity of productivity management and the need for a comprehensive approach to optimizing production processes. Implementing lean manufacturing principles and quality management systems are identified as key strategies to reduce costs and increase efficiency. The article concludes that a holistic approach involving technological innovation and strategic human resource development is essential for the sustainable growth and competitiveness of the industry.
POTENTIAL OF APPLYING THE INPUT-OUTPUT METHOD FOR THE NEEDS OF RUSSIAN BUSINESS IN INTERNATIONAL TRADE
Authors:   Institute of International Studies, Moscow State Institute of International Relations (University) Russian Foreign Ministry, Moscow, Russia, Bondarev I. M.
Published: August 2024

The article considers the application of the Leontief Input-Output Method to assess the prospects of foreign trade operations. The author briefly describes the functioning of the basic model of interindustry balance of V. V. Leontief and the world experience of its application. Leontief’s basic model of interindustry balance and the world experience of its application. Potential fields of using the input-output method for the needs of Russian business related to foreign trade are noted. As an illustration of the applicability of the method, a scenario of its use in the course of export operations by a Russian company to one of the Latin American countries is modeled.
PROBLEMS OF ACTIVITY OF SMALL AND MEDIUMSIZED ENTERPRISES OF THE NORTH-WEST – SUBJECTS OF CRITICAL INFORMATION INFRASTRUCTURE
Authors:   St. Petersburg State University of Aerospace Instrumentation, Polonsky Alexander M. ,   JSC “Research Institute of Electromera”, St. Petersburg, Russia
Published: August 2024

Numerous enterprises of the Northwestern Federal District traditionally carry out work in the interests of the Russian Ministry of Defense, most of them are small and medium-sized businesses. Currently these enterprises belong to the enterprises of the military-industrial complex (MIC) and are subjects of critical information infrastructure. As a result, these enterprises faced a number of intractable problems – enterprises need to classify their critical information infrastructure facilities and ensure the required security measures. The article discusses the issues of categorization of objects of critical information infrastructure and interaction in matters of security with regulators in this area – the FSTEC of Russia and the FSB of Russia.
EFFECTS OF SPRAYING CEMELE PEPPER (Capsicum annuum L.) EXTRACTS ONTO HATCHING EGGS OF ATAK-S LAYER HENS ON HATCHING RESULTS, SERUM GLUTATHIONE AND MALONDIALDEHYDE LEVELS
Authors: Ergun F , Taskin A , Ergun D
Published: August 2024

Alternative natural products have been used in hatching since chemicals used in the incubation of chicken eggs have toxic effects on the embryo, the practitioners and the environment. In this study with completely randomized design (CRD) the effects of a registered local pepper (Cemele) extract at different dosages in the incubation process of hatching eggs was examined. The chloride group disinfectant (T1), ethanol (T2), 2% pepper extract (T3), and 4% pepper extract (T4) were sprayed on to disinfect eggs before the incubation process. On the second, eighth, and eighteenth incubation days of the groups, the total mesophilic aerobic bacteria (TMAB) loads of the eggshell were examined, and the lowest load values were found at T4. In this study, the highest hatching efficiency (H) and the highest fertilised hatching rate (HF) were 87.52±2.88% and 81.66±1.44%, respectively, in T4. Early embryonic mortality (EEM) was not observed at T4, while the highest value was 7.11±1.35% at T2. The highest mid embryonic mortality (MEM) rate was 10.91±0.34% in T3 while the lowest rate was 7.11±1.35% in T4. The late embryonic mortality (LEM) rates were 14.22±2.69% in T2, 12.47±1.17% in T1, 12.66±2.69% in T3 and 5.30±0.17% in T4. The lowest malposition rate 8.92±0.01% and the lowest malformation rate 8.83±0.12% were observed in T4. At the end of this study, body weights, lengths, tona, and pasgar scores of the hatched chicks were calculated. The highest body weight and length values were observed as 43.57±1.37 g and 16.47±0.45 cm in T4 birds, respectively. The highest tona score was 98.10±1.27 in T4 and the lowest tona score was 93.65±1.22 in T1 birds. Pasgar score values of the chicks were 9.69±0.16 in T4, 9.38±0.17 in T2, 9.31±0.18 at T3 and 9.16±0.16 in T1, respectively. The MDA values of birds were 8.63±0.05, 0.70±0.10, 0.28±0.01 and 0.25±0.01 nmol mL-1 in T1, T2, T3 and T4, respectively while the highest GSH value was 32.39±0.66 M in T4, and the lowest value 11.15±1.03M in T2. In conclusion, the use of Cemele pepper extract had positive results in the incubation process of hatching eggs.
Key Words: Incubation process, disinfectant, chlorine dioxide, ethanol, cemele pepper.
Cover, Editorial Team and Table of Contents
Authors: Team Editorial
Published: August 2024

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A rare case report of paratesticular leiomyosarcoma
Authors: Nimkar Santosh , Glass Bianca , Dalia Samir
Published: August 2024

A leiomyosarcoma (LMS) is a malignant mesenchymal tumor of soft tissue that rarely presents in the scrotal region. This case report describes a primary paratesticular LMS originating in the dartos layer of the scrotum in a symptomatic 37-year-old male with a history of hypertension, generalized seizure disorder post-excision of meningioma, and an extensive family history of cancer. Primary paratesticular LMSs in the superficial dartos layer are exceedingly rare. Given the rarity of this particular type of LMS, this case report includes a discussion on its prevalence and incidence. The rarity of this tumor also warrants a review of the literature and related cases to inform the treatment plan and enhance understanding of these oncologic conditions.
Kualitas Audit: Pengaruh Independensi Dan Pengalaman Auditor Kap Di Kota Bandung
Authors: Arsalan Syakieb , Dewi Herawati Shinta , Tresnawati Rina
Published: August 2024

Penelitian ini bertujuan untuk membuktikan secara empiris pengaruh independensi dan pengalaman auditor terhadap kualitas audit. Penelitian ini dilakukan terhadap auditor yang bekerja di Kantor Akuntan Publik Kota Bandung. Penelitian ini menggunakan metode deskriptif kuantitatif. Sumber data yang digunakan adalah data primer dengan pengumpulan data menggunakan kuesioner terhadap 80 responden auditor KAP di kota Bandung. Analisis data menggunakan metode regresi linier berganda, tujuannya adalah untuk dapat mengetahui pengaruh antar variabel dengan bantuan aplikasi JASP versi 0.16.4.0. Hasil penelitian ini menunjukkan variabel independensi dan pengalaman audit mempunyai pengaruh signifikan terhadap kualitas audit. Hal ini menunjukkan bukti independensi dan pengalaman auditor di Kota Bandung yang masih tinggi dan tercermin pada kualitas audit
Faktor-Faktor Yang Mempengaruhi Retensi Karyawan Di Rumah Sakit Di Kota Batam
Authors: Nelson Alden , Apriyana Tirani
Published: August 2024

Penelitian ini dibuat dengan tujuan untuk melihat pengaruh retensi karyawan terhadap karyawan rumah sakit di Kota Batam. Pada saat ini persaingan sumber daya manusia semakin ketat sehingga organisasi memerlukan perkembangan sumber daya manusia guna mencapai tujuan organisasi yang optimal. Organisasi dapat mengelola sumber daya manusia yang baik untuk memastikan kelangsungan hidup organisasi dalam konteks keseimbangan ekonomi dalam jangka panjang, karena bagi organisasi yang terus beroprerasi sumber daya manusia adalah fondasi. Penelitian ini membahas mengenai faktor - faktor pengaruh dari usaha peningkatan retensi karyawan pada rumah sakit tipe B di Kota Batam. Metode pengumpulan data, metode pengolahan data, dan analisis data adalah método pengolahan data yang digunakan penulis dalam penelitian ini. Hasil dari penelitian ini memperlihatkan bahwa variabel kompensasi, kepuasan kerja, dan keterlibatan karyawan terbukti memiliki pengaruh yang signifikan positif terhadap retensi karyawan. Berbeda dengan itu variabel keseimbangan kehidupan kerja dan manajemen bakat tidak terbukti memiliki pengaruh signifikan terhadap retensi karyawan
Pengaruh Sektor Pertanian, Sektor Pertambangan, dan Sektor Industri Pengolahan di Provinsi Sumatera Utara
Authors: Putra Fanolo Hia Sungguh , Damanik Darwin , Nainggolan Pinondang
Published: August 2024

Penelitian ini bertujuan untuk mengetahui pengaruh sektor pertanian, sektor pertambangan, dan sektor industri pengolahan terhadap pertumbuhan ekonomi. Jenis data adalah data sekunder dari BPS Sumut 2018-2022, dengan objek penelitian sebanyak 33 Kabupaten/Kota di Provinsi Sumatera Utara. Metode analisis yang digunakan adalah metode analisis regresi data panel dengan FEM pada model satu dan dua, pada model tiga dan empat menggunakan model REM. Hasil pengujian model satu pada X1 berpengaruh negatif namun signifikan terhadap variabel Y. Variabel X2 berpengaruh negatif namun signifikan terhadap variabel Y. Variabel X3 berpengaruh positif dan signifikan terhadap variabel Y dan secara bersama - sama variabel X1, X2 dan X3 berpengaruh signifikan terhadap variabel Y. Pada model dua membuktikan bahwa variabel X1 berpengaruh positif namun tidak signifikan terhadap variabel Y. Variabel X2 berpengaruh positif dan signifikan terhadap variabel Y. Variabel X3 berpengaruh positif dan signifikan terhadap variabel Y dan secara bersama - sama variabel X1, X2 dan X3 berpengaruh signifikan terhadap variabel Y. Pada model tiga membuktikan bahwa variabel X1 berpengaruh negatif dan tidak signifikan terhadap variabel Y. Variabel X2 berpengaruh positif dan signifikan terhadap variabel Y. Variabel X3 berpengaruh positif dan signifikan terhadap variabel Y dan secara bersama - sama variabel X1, X2 dan X3 berpengaruh signifikan terhadap variabel Y. Pada model empat membuktikan bahwa variabel X1 berpengaruh negatif dan tidak signifikan terhadap variabel Y. Variabel X2 berpengaruh positif dan signifikan terhadap variabel Y. Variabel X3 berpengaruh positif dan signifikan terhadap variabel Y dan secara bersama - sama variabel X1, X2 dan X3 memiliki pengaruh signifikan terhadap variabel Y
PERILAKU PETANI DALAM PENGGUNAAN MESIN PERONTOK PADI (Combine Harvester) DESA BONGOMEME KECAMATAN DUNGALIYO KABUPATEN GORONTALO
Authors: Ibrahim Kristian , Bempah Irwan , Saleh Yanti
Published: August 2024

Kristian Ibrahim. Perilaku Petani Dalam Penggunaan Mesin Perontok Padi (Combine Harvester) Desa Bongomeme Kecamatan Dungaliyo Kabupaten Gorontalo. Di bimbing oleh Dr. Irwan Bempah dan Yanti Saleh. Penelitian ini  bertujuan untuk: 1) mengetahui bagaimana karakteristik petani dalam menggunaan mesin Combine Hervester di Desa Bongomeme, Kecamatan Dungaliyo, Kabupaten Gorontalo. 2) mengetahui bagaimana perilaku petani dalam penggunaan mesin Combine Hervester di Desa Bongomeme, Kecamatan Dungaliyo, Kabupaten Gorontalo. Jumlah responden dalam penelitian berjumlah 39 responden dari berbagai kelompok tani yang berada di Desa Bongomeme. Penilitian ini menggunakan metode Deskriptif dengan pendekatan kualitatif ini di karenakan penelti melakukan kontak langsung dengan para responden dan juga objek yang diteliti yang berada langsung di tempat mereka. Hasil pelitian ini menggunakananalisis Deskriptif dengan menggunakan skala likert dengan hasil penelitian ini yakni indikator kontrol perilaku pribadi memiliki kategori cukup baik dengan jumlah presentase 63.07%, kemudian  kedua yakni pengetahuan memiliki kategori cukup baik dengan jumlah presentase 58.87%, selanjutnya sikap berada pada urutan ketiga dengan memiliki kategori  cukup baik dengan jumlah presentase 56.20%, dan yang terakhir niat memiliki kategori  kurang baik dengan jumlah presentase 51.68%. Berdasarkan data pada penelitian ini kontrol perilaku pribadi petani merupan aspek penting dalam proses perubahan suatu inovasi dari yang tradisional ke modern dengan dibantunya oleh pihak yang terkait yakni dari segi pemerintahan yang dalam hal ini para penyuluh.
Anticoagulation régionale par citrate en épuration extra rénale
Authors: Bouilland Anne-Laure , Bruant Amélie , Monchi Mehran
Published: August 2024

En chélatant le calcium ionisé au niveau du circuit extra corporel, le citrate permet une anticoagulation du circuit sans exposer le patient à une anticoagulation systémique. L'anticoagulation au citrate réduit également l’activation des leucocytes et des plaquettes au niveau du circuit. Le citrate injecté au niveau du circuit forme des complexes Calcium-citrate, éliminés en partie au niveau de la membrane. Les complexes non éliminés par le circuit sont métabolisés au niveau des cellules du patient par le cycle des acides tricarboxyliques, surtout au niveau du foie, libérant du bicarbonate et du calcium ionisé. Un apport de calcium est donc nécessaire pour compenser le calcium éliminé par la membrane. En épuration extrarénale continue, l’anticoagulation par citrate est associée à une durée de vie plus prolongée des circuits et un risque hémorragique plus faible. En épuration extra rénale intermittente, le citrate est moins utilisé. Il n’existe pas de toxicité directe du citrate. Les effets secondaires de l’anticoagulation au citrate sont essentiellement un risque d’hypo ou d’hypercalcémie chez le patient en cas d’apports de calcium en excès ou insuffisants, et des perturbations acido-basiques si la genèse de bicarbonate par les cellules métabolisant le citrate n’est pas prise en compte dans les solutés utilisés pour l’épuration extra rénale.
Building Renovation by Using Maximum Edge Distance Method
Authors: Priyadharshini S. , Deepa G.
Published: August 2024

In this competitive world, it is becoming more difficult to manipulate the entities for project managers and organizers to come up with successful project management strategies. Here, we introduce the Maximum Edge Distance (MED) methodology to determine the adequate solution for finding an intuitionistic fuzzy critical path (IFCP) for building renovation work. This methodology incorporates the use of intuitionistic fuzzy sets, allowing for the consideration of uncertainty and vagueness in the analysis. The Maximum Edge Distance approach involves assigning weights or distances to edges in the project network, optimizing the renovation work schedule by considering factors such as time, resource availability, and uncertainty. We used data from a construction company called Mega Star Technical, which specializes in renovations and building construction at Nigeria. This investigation will use the IFCP. Forward pass and backward pass computations are used for verification. MATLAB is used to manifest the simulation results. Finally, the results of this method demonstrate that the project is likely to be accomplish within the stated time range.
Analisis Pemanfaatan Tanah Wakaf Sebagai Tanah Makam Perspektif Fikih (Studi Kasus di Desa Jelegong Kecamatan Rancaekek Kabupaten Bandung)
Authors: Rais Aminurdin Latifaza , Irsan
Published: August 2024

Penelitian ini bertujuan menganalisis pemanfaatan tanah wakaf sebagai pemakaman khususnya yang terjadi di Desa Jelegong Kecamatan Rancaekek Kabupaten Bandung dalam perspektif fikih. Penelitian ini menggunakan pendekatan kualitatif dengan metode studi kasus untuk memahami dan menjelaskan fenomena yang ada secara mendalam. Data dikumpulkan melalui wawancara, studi kasus, dan dokumentasi. Hasil penelitian menunjukkan bahwa warga tetap Permata Hijau yang telah berkontribusi dalam pembelian tanah wakaf memiliki hak untuk dimakamkan di tanah tersebut, sedangkan non-warga tetap atau warga pengontrak harus membayar pengganti lahan yang digunakan jika ingin dimakamkan di tanah tersebut. Dalam perspektif fikih, ketentuan pemanfaatan tanah wakaf ini tidak bertentangan dengan syariat Islam, karena pengaturan pemanfaatan tanah wakaf oleh warga tetap sesuai dengan prinsip wakaf, dan pembayaran oleh non-warga tetap bukan merupakan praktik jual-beli yang dilarang, melainkan untuk pemeliharaan dan pengembangan tanah wakaf.
This research aims to analyze the utilization of waqf land as a cemetery, particularly in Jelegong Village, Rancaekek Subdistrict, Bandung Regency, from a fiqh perspective. The research employs a qualitative approach with a case study method to understand and explain the existing phenomenon in depth. Data were collected through interviews, case studies, and documentation. The results of the research show that permanent residents of Permata Hijau who have contributed to the purchase of the waqf land have the right to be buried there, while non-permanent residents or tenants must pay a fee for the land used if they wish to be buried there. From a fiqh perspective, the provisions for utilizing the waqf land do not contradict Islamic law, because the management of the waqf land by permanent residents aligns with the principles of waqf, and the payment by non-permanent residents is not considered a prohibited sale transaction, but rather for the maintenance and development of the waqf land.
Pengaruh lama waktu penggorengan (frying pan) terhadap kadar lemak ikan seluang (Rasbora sp.)
Authors: Ambeng Qeyla Resido , Yuliani Ni Nyoman Sri , Balyas Abi Bakring
Published: August 2024

Menurut WHO, terdapat 4 faktor utama yang mempengaruhi kejadian stunting yaitu faktor maternal dan lingkungan, faktor hambatan dalam pemberian ASI, faktor infeksi, serta faktor complementary feeding. Lemak merupakan salah satu zat gizi yang berpengaruh terhadap proses tumbuh kembang anak dan banyak ditemukan dalam beberapa bahan makanan salah satunya ikan seluang. Kandungan zat gizi yang terkandung pada ikan seluang segar per 100 g terdiri dari protein 47,54 mg, lemak 12,36 mg, 21,53 kilo kalori, zat besi 2,9 ppm, tembaga 0,38 ppm, dan seng 3,64 ppm. Penelitian ini bertujuan untuk mengetahui pengaruh lama waktu penggorengan terhadap kadar lemak ikan dan mengetahui lama waktu terbaik yang dapat mempertahankan kadar lemak dalam ikan seluang dan menggunakan metode penelitian eksperimental. Rancangan yang dipakai pada penelitian ini merupakan rancangan penelitian acak lengkap, objek berupa ikan seluang diberikan perlakuan dengan cara digoreng dengan ketiga jenis waktu yang berbeda. Ada perbedaan kadar lemak antara lama penggorengan 7,5 menit, 8 menit dan 8,5 menit dengan nilai p=0,004 (<0,05). Terdapat pengaruh lama waktu penggorengan terhadap kadar lemak ikan seluang (p<0,05). Lama waktu terbaik yang dapat mempertahankan kadar lemak dalam ikan Seluang adalah 7,5 menit.
PENGARUH PENDIDIDIKAN KESEHATAN AUDIOVISUAL TERHADAP PENGETAHUAN ORANG TUA MENCEGAH STUNTING PADA BALITA DI DESA MINAHASA UTARA
Authors: Bayu Dwisetyo
Published: August 2024

One of the main Stunting or dwarf is a condition when toddlers experience the failure of growth it caused by poor nutritional status of the children under five years. The Method of this study is to determine the effectiveness of audiovisual media on health education of parent's. The design of this study use a quasi-experimental (one group pre-test and post-test design). The population in this study found 112 parents. The samples taken 17 respondents by using purposive sampling. The research instrument is a questionnaire. Then the data collected and processed for analysis using the Mc Nemar test. The results of this study indicate, most of the poor knowledge of parents decreased after being given audiovisual media on health education. The results of data analysis using Mc Nemar test with p value = 0.000 (< 0.05), thus the alternative hypothesis (Ha) is accepted. The conclusion of this study is audiovisual media on health education on parental knowledge of preventing stunting in toddlers at Minaesa Minahasa. Suggestions to respondents, to seek more information about stunting prevention.