bluuebunny/crossref_metadata_2025 huggingface dataset:
N/N Bridge Type and Substituent Effects on Chemical and Crystallographic Properties of Schiff-Base (Salen/Salphen) Niii Complexes
Authors: Novoa-Ramírez Cynthia S. , Silva-Becerril Areli , Olivera-Venturo Fiorella L. , García-Ramos Juan Carlos , Flores-Alamo Marcos , Ruiz-Azuara Lena
Published: July 2020

In total, 13 ligands R-salen (N,N’-bis(5-R-salicylidene)ethylenediamine (where R = MeO, Me, OH, H, Cl, Br, NO2) and R-salphen (N,N’-bis(5-R-salicylidene)-1,2-phenylenediamine (where R = MeO, Me, OH, H, Cl, Br) and their 13 nickel complexes NiRsalen and NiRsalphen were synthesized and characterized using IR (infrared) spectroscopy, mass spectrometry, elemental analysis, magnetic susceptibility, NMR (nuclear magnetic resonance), UV-vis (ultraviolet-visible) spectroscopy, cyclic voltammetry, and X-ray crystal diffraction. Previous studies have shown that all complexes have presented a square planar geometry in a solid state and as a solution (DMSO). In electrochemical studies, it was observed that in N/N aliphatic bridge complexes, the NiII underwent two redox reactions, which were quasi-reversible process, and the half-wave potential followed a trend depending on the ligand substituent in the 5,5’-R position. The electron-donor substituent—as -OH, and -CH3 decreased the E1/2 potential—favored the reductor ability of nickel. The crystals of the complexes NiMesalen, NiMeOsalen, NiMeOsalphen, and Nisalphen were obtained. It was shown that the crystal packaging corresponded to monoclinic systems in the first three cases, as well as the triclinic for Nisalphen. The Hirshfeld surface analysis showed that the packaging was favored by H∙∙∙H and C∙∙∙H/H∙∙∙C interactions, and C-H∙∙∙O hydrogen bridges when the substituent was -MeO and π-stacking was added to an aromatic bridge. Replacing the N/N bridge with an aromatic ring decreased distortion in square-planar geometry where the angles O-Ni-N formed a perfect square-planar.
Zeolite-Like Boron Imidazolate Frameworks (BIFs): Synthesis and Application
Authors: Isaeva Vera I. , Papathanasiou Kostantinos E. , Kustov Leonid M.
Published: July 2020

This review is devoted to discussion of the latest advances in design and applications of boron imidazolate frameworks (BIFs) that are a particular sub-family of zeolite-like metal–organic frameworks family. A special emphasis is made on nanostructured hybrid materials based on BIF matrices and their modern applications, especially in environment remediation and energy conversion.
Radar Signal Sorting Method Based on Radar Coherent Characteristic
Authors: Xue Jian , Tang Lan , Zhang Xinggan , Jin Lin
Published: July 2020

Aiming at the problem of reliability reduction of signal sorting in terms of the traditional five parameters and intrapulse feature in a complex electromagnetic environment, a new signal sorting method based on radar coherent characteristics is proposed. The main idea of this method is using spectrum analysis to obtain the spectrum images of coherent and noncoherent signals. Image-processing technology is used to extract the feature difference between the two spectrum images, and the central-moment feature is introduced to describe this difference. Through simulation analysis, the feasibility of using the central-moment feature as the coherent feature for signal sorting was proved. In order to check the effectiveness of the proposed feature, a number of simulations were conducted to demonstrate the sorting capability in terms of the coherent feature. From the simulations, it can be seen that the proposed feature not only can be used as a new feature for signal sorting but also that it can be utilized as a supplement for five typical parameters and the intrapulse feature to improve the sorting accuracy rate. Simulations also showed the proposed method could achieve satisfactory sorting results in a low signal-to-noise ratio (SNR). When the SNR was 5 dB, the sorting accuracy rate could reach 98%.
Perceptual Metric Guided Deep Attention Network for Single Image Super-Resolution
Authors: Sun Yubao , Shi Yuyang , Yang Ying , Zhou Wangping
Published: July 2020

Deep learning has been widely applied to image super-resolution (SR) tasks and has achieved superior performance over traditional methods due to its excellent feature learning capabilities. However, most of these deep learning-based methods require training image sets to pre-train SR network parameters. In this paper, we propose a new single image SR network without the need of any pre-training. The proposed network is optimized to achieve the SR reconstruction only from a low resolution observation rather than training image sets, and it focuses on improving the visual quality of reconstructed images. Specifically, we designed an attention-based decoder-encoder network for predicting the SR reconstruction, in which a residual spatial attention (RSA) unit is deployed in each layer of decoder to capture key information. Moreover, we adopt the perceptual metric consisting of L1 metric and multi-scale structural similarity (MSSSIM) metric to learn the network parameters. Different than the conventional MSE (mean squared error) metric, the perceptual metric coincides well with perceptual characteristics of the human visual system. Under the guidance of the perceptual metric, the RSA units are capable of predicting the visually sensitive areas at different scales. The proposed network can thus pay more attention to these areas for preserving visual informative structures at multiple scales. The experimental results on the Set5 and Set14 image set demonstrate that the combination of Perceptual metric and RSA units can significantly improve the reconstruction quality. In terms of PSNR and structural similarity (SSIM) values, the proposed method achieves better reconstruction results than the related works, and it is even comparable to some pre-trained networks.
Rapid Fault Diagnosis of PEM Fuel Cells through Optimal Electrochemical Impedance Spectroscopy Tests
Authors: Najafi Behzad , Bonomi Paolo , Casalegno Andrea , Rinaldi Fabio , Baricci Andrea
Published: July 2020

The present paper is focused on proposing and implementing a methodology for robust and rapid diagnosis of PEM fuel cells’ faults using Electrochemical Impedance Spectroscopy (EIS). Accordingly, EIS tests have been first conducted on four identical fresh PEM fuel cells along with an aged PEMFC at different current density levels and operating conditions. A label, which represents the presence of a type of fault (flooding or dehydration) or the regular operation, is then assigned to each test based on the expert knowledge employing the cell’s spectrum on the Nyquist plot. Since the time required to generate the spectrum should be minimized and considering the notable difference in the time needed for carrying out EIS tests at different frequency ranges, the frequencies have been categorized into four clusters (based on the corresponding order of magnitude: >1 kHz, >100 Hz, >10 Hz, >1 Hz). Next, for each frequency cluster and each specific current density, while utilizing a classification algorithm, a feature selection procedure is implemented in order to find the combination of EIS frequencies utilizing which results in the highest fault diagnosis accuracy and requires the lowest EIS testing time. For the case of fresh cells, employing the cluster of frequencies with f > 10 Hz, an accuracy of 98.5 % is obtained, whereas once the EIS tests from degraded cells are added to the dataset, the achieved accuracy is reduced to 89.2 % . It is also demonstrated that, while utilizing the selected pipelines, the required time for conducting the EIS test is less than one second, an advantage that facilitates real-time in-operando diagnosis of water management issues.
Hardware Implementation and Performance Study of Analog PIλDμ Controllers on DC Motor
Authors: John Dina A. , Sehgal Saket , Biswas Karabi
Published: July 2020

In this paper, the performance of an analog PI λ D μ controller is done for speed regulation of a DC motor. The circuits for the fractional integrator and differentiator of PI λ D μ controller are designed by optimal pole-zero interlacing algorithm. The performance of the controller is compared with another PI λ D μ controller—in which the fractional integrator circuit employs a solid-state fractional capacitor. It can be verified from the results that using PI λ D μ controllers, the speed response of the DC motor has improved with reduction in settling time ( T s ), steady state error (SS error) and % overshoot (% M p ).
Two-Step Floating Catchment Area Model-Based Evaluation of Community Care Facilities’ Spatial Accessibility in Xi’an, China
Authors: Liu Sunwei , Wang Yupeng , Zhou Dian , Kang Yitong
Published: July 2020

Due to the rapid increase in the number of elderly people in Chinese cities, the development and planning of aged care facilities, and particularly community care facilities, which will gradually become the mainstream choice for the elderly in China, is becoming an important topic for urban sustainability. Previous studies have shown that the number and scale of aged care facilities in many cities are far from meeting the needs of the elderly and the overall occupation rate is low. Some of these cities are still expanding and some are undergoing urban renovation. In this process, the scientific planning of community care facilities to promote efficient use of facility resources has become an urgent problem that needs to be solved. In this study, the two-step floating catchment area (2SFCA) method and a potential model based on the Geographic Information System (GIS) were used to carry out a scientific evaluation of the spatial accessibility of community care facilities in the Beilin district of Xi’an. The aims were to explore the best quantitative research methods for assessing the distribution of Xi’an community care facilities’ spatial accessibility, provide ideas for similar studies in the future, and further the understanding of spatial allocation of urban community care facilities resources.
Prevalence and Predictors of Insulin Resistance in Non-Obese Healthy Young Females in Qatar
Authors: Elrayess Mohamed A. , Rizk Nasser M. , Fadel Amina S. , Kerkadi Abdelhamid
Published: July 2020

The state of Qatar suffers from diabetes epidemic due to obesity-associated metabolic syndrome. However, the prevalence of insulin resistance prior to obesity, which could play an important role in the high prevalence of diabetes, has not yet been described. This study aims to compare the prevalence of insulin resistance in apparently healthy non-obese and obese participants from Qatar and identify the predictors of insulin resistance in different body mass index (BMI)-groups. In this cross-sectional study, 150 young healthy females from Qatar were dichotomized into four groups (underweight, normal weight, overweight and obese) based on their BMI. Anthropometric measures as well as fasting plasma levels of lipids, adipokines, blood glucose and insulin were recorded. The prevalence of insulin resistance as per homeostatic model assessment of insulin resistance (HOMA-IR) was estimated and differences between insulin sensitive and insulin resistant were compared. Linear models were used to identify predictors of insulin resistance in every BMI group. Prevalence of insulin resistance in non-obese healthy females from Qatar ranges between 7% and 37% and increases with BMI. Overall, predictors of insulin resistance in the Qatari population are triglycerides/high-density lipoprotein (HDL) ratio and free fat mass but vary according to the BMI group. The main predictors were triglycerides in normal weight, triglycerides/HDL in overweight and triglycerides/HDL and interleukin-6 (IL-6) in obese individuals. The high prevalence of insulin resistance in non-obese Qataris may partially explain diabetes epidemic. Larger studies are warranted to confirm these findings and identify underlying causes for insulin resistance in non-obese individuals in Qatar, aiming at targeted intervention before diabetes onset.
Association between the Genetic Variants of Glutathione Peroxidase 4 and Severity of Endometriosis
Authors: Huang Yun-Yao , Wu Cheng-Hsuan , Liu Chung-Hsien , Yang Shun-Fa , Wang Po-Hui , Lin Long-Yao , Lee Tsung-Hsien , Lee Maw-Sheng
Published: July 2020

It has been reported that oxidative and nitrative stress might be the pathogenesis of endometriosis. This prospective case-control study attempted to check the connection between single nucleotide polymorphism (SNP) of three antioxidant enzymes (glutathione peroxidase 4 (GPX4), thioredoxin 2 (TXN2), thioredoxin reductase 1 (TXNRD1)) and endometriosis. We recruited 90 patients with histology-approved endometriosis as the case group and 130 age-matched women for an annual pap smear examination as the control group. The stage of endometriosis was evaluated with revised ASRM score. Both groups were genotyped in the peripheral leukocytes for the SNP of GPX4 (rs713041), TXN2 (rs4821494) and TXNRD1 (rs1128446) by PCR-based methods. An X2 test was used to analysis of the difference of allele frequency and SNP distribution between two groups. The results revealed GPX4 (rs713041) has a significantly different distribution between two groups (C:T = 116 (44.6%):144 (55.4%) in control and C:T = 104 (57.8%): 76 (42.2%) in endometriosis groups, p = 0.007). The SNP in TXN2 (rs4821494) also showed a difference in allele frequency (G:T = 180 (69.2%):80 (30.8%) in control and G:T = 141 (78.3%):39 (21.6%) in endometriosis group, p = 0.030). In addition, the SNP GPX4 (rs713041) was associated with the severity of the endometriosis. Women who have advanced stage endometriosis were different from mild endometriosis in genetic variants of GPX4 gene (p = 0.001). In conclusion, the relationship between endometriosis and SNP of antioxidant enzymes, GPX4 and TXN2, was confirmed by the present study. According to the result, we suggested that the GPX4 might contribute to the pathogenesis of endometriosis.
Long-Term Combined Training in Idiopathic Pulmonary Fibrosis: A Case Study
Authors: Naranjo-Orellana José , Santalla Alfredo
Published: July 2020

A supervised combined training program was applied to a sedentary 56-year-old man with idiopathic pulmonary fibrosis (IPF) along three years, until lung transplantation. It included: (a) aerobic continuous (CT) and interval training (IT), (b) high load resistance training (RT) and (c) inspiratory muscle training (IMT). IT and IMT were applied for two years, while CT and RT could be maintained until transplantation using supplemental oxygen. Maximal inspiratory pressure (MIP) kept above 180 cm H2O and forced vital capacity (FVC) remained stable until lung transplantation. Peak oxygen uptake VO2 increased during 1.5 years before its decline, staying above the poor prognosis level two years. Finally, the patient maintained his walking capacity and independence for 2 years, before the decline due to the disease. After receiving a two-lung transplant, the patient remained intubated for 12 h, left the intensive care unit after 3.5 days and was discharged after 18 days (average values: 48 h, 7–10 days and 25–35 days, respectively). These results show that systematic and supervised combined training can be safety applied in an IPF patient to maintain functionality and quality of life. In addition, we show that RT can be maintained for as long as necessary without complications.
Prevalence and Socio-Demographic, Academic, Health and Lifestyle Predictors of Illicit Drug/s Use among University Undergraduate Students in Finland
Authors: El Ansari Walid , Salam Abdul , Suominen Sakari
Published: July 2020

Illicit drug/s use (IDU) among university students is a public health concern. We assessed the associations between socio-demographic, academic, and health and lifestyle characteristics (independent variables) and regular, occasional or never IDU (dependent variables). Data were collected across seven faculties (1177 students) at the University of Turku (Finland) via an online questionnaire. About 1.5% of the sample had regular IDU, 19% occasional IDU, and 79% never IDU. Independent predictors of ever (lifetime) IDU included males [adjusted odds ratio (AOR) 1.82, P = 0.001], not living with parents (AOR 2.59, P < 0.001), singles (AOR 0.51, P < 0.001), lower religiosity (AOR 1.49, P = 0.022), better self-rated general health (AOR 0.41, P = 0.003), higher health awareness (AOR 1.93, P = 0.014), more depressive symptoms (AOR 1.82, P = 0.004), daily smokers (AOR 3.69, P < 0.001), heavy episodic drinking (AOR 2.38, P < 0.001) and possible alcohol dependency (AOR 2.55, P < 0.001). We observed no independent associations between ever IDU with age, study discipline, perceived stress or academic performance. The 20.5% ever IDU is concerning. The compelling independent predictors of ever IDU included not living with parents, lower religiosity, daily smokers, heavy episodic drinking and possible alcohol dependency (AOR range 2.38–3.69). Education and prevention need to emphasize the negative consequences to reinforce abstinence from IDU. Health promotion could focus on beliefs and expectations about IDU and target students at risk for successful efforts.
Health Surveillance and Response to SARS-CoV-2 Mass Testing in Health Workers of a Large Italian Hospital in Verona, Veneto
Authors: Porru Stefano , Carta Angela , Monaco Maria Grazia Lourdes , Verlato Giuseppe , Battaggia Andrea , Parpaiola Marco , Lo Cascio Giuliana , Pegoraro Manuela , Militello Valentina , Moretti Francesca , Tardivo Stefano
Published: July 2020

Italy presented the first largest COVID-19 outbreak outside of China. Veneto currently ranks fourth among the Italian regions for COVID-19 confirmed cases (~19,000). This study presents health surveillance data for SARS-CoV-2 in 6100 health workers (HW) employed in a large public hospital. Workers underwent oropharyngeal and nasopharyngeal swabs, with a total of 5942 participants (97.5% of the population). A total of 11,890 specimens were tested for SARS-CoV-2 infection using PCR, identifying the viral genes E, RdRP, and N. Positive tests were returned for 238 workers (cumulative incidence of 4.0%, similar in both COVID and nonCOVID units). SARS-CoV-2 risk was not affected by gender, age, or job type, whereas work setting and occupation were both predictors of infection. The risk was higher in medical wards (OR 2.7, 95% CI 1.9–3.9) and health services (OR 4.3, 95% CI 2.4–7.6), and lower in surgical wards and administration areas. To our knowledge, this study represents the largest available HW case list swab-tested for SARS-CoV-2, covering almost the total workforce. Mass screening enabled the isolation of HW, improved risk assessment, allowed for close contacts of and infected HW to return to work, provided evidence of SARS-CoV-2 diffusion, and presented solid ground to prevent nosocomial SARS-CoV-2 infections. The ongoing concurrent sero-epidemiological study aims to enable the improvement of health surveillance to maintain the safety of HWs and the communities they serve.
Antimicrobial Efficacy of Fruit Peels Eco-Enzyme against Enterococcus faecalis: An In Vitro Study
Authors: Mavani Hetal Ashvin Kumar , Tew In Meei , Wong Lishen , Yew Hsu Zenn , Mahyuddin Alida , Ahmad Ghazali Rohi , Pow Edmond Ho Nang
Published: July 2020

Sodium hypochlorite (NaOCl), an effective endodontic irrigant against Enterococcus faecalis (EF), is harmful to periapical tissues. Natural pineapple-orange eco-enzymes (M-EE) and papaya eco-enzyme (P-EE) could be potential alternatives. This study aimed to assess the antimicrobial efficacy of M-EE and P-EE at different concentrations and fermentation periods against EF, compared to 2.5% NaOCl. Fermented M-EE and P-EE (3 and 6 months) at various concentrations were mixed with EF in a 96-well plate incubated for 24 h anaerobically. Minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC) of M-EE and P-EE were determined via EF growth observation. EF inhibition was quantitatively measured and compared between different irrigants using the one-way analysis of variance (ANOVA), and different fermentation periods using the independent-samples T-test. M-EE and P-EE showed MIC at 50% and MBC at 100% concentrations. There was no significant difference in antimicrobial effect when comparing M-EE and P-EE at 50% and 100% to 2.5% NaOCl. P-EE at 6 months fermentation exhibited higher EF inhibition compared to 3 months at concentrations of 25% (p = 0.017) and 0.78% (p = 0.009). The antimicrobial properties of M-EE and P-EE, at both 100% and 50% concentrations, are comparable to 2.5% NaOCl. They could therefore be potential alternative endodontic irrigants, but further studies are required.
Effect of Viewing Video Representation of the Urban Environment and Forest Environment on Mood and Level of Procrastination
Authors: Bielinis Ernest , Simkin Jenni , Puttonen Pasi , Tyrväinen Liisa
Published: July 2020

A common problem among students is the problem of delaying important work activities, which is conceptualized as procrastination. Since procrastination can cause considerable costs for society, we would like to find a method to effectively alleviate the symptoms of this conditioning. It has been proven in an earlier study that staying in the forest environment increases vitality and reduces anxiety, and the negative state of these features can be associated with the intensification of procrastination symptoms. Therefore, it is likely that watching a forest video may decrease the probability or intensity of procrastination. To measure the impact of the forest environment on the level of procrastination of the subjects, a randomized experiment was carried out, in which the subjects watched in random order (on different days) one of two 15-min videos: one showing a walk in the forest area and one showing a walk in an urban environment (control). We measured the level of so-called ‘fluid procrastination’ including three aspects: ‘lack of energy to do the work’, ‘inability to get to work’ and ’pessimistic attitude to do the work’ with a set of questions the respondents completed before and after the experiment. The results showed that one aspect of fluid procrastination (‘pessimistic attitude to do the work’) can be effectively lowered by watching a video showing the forest environment. In contrast, watching a video of an urban environment increased the procrastination levels for two other aspects of procrastination (‘lack of energy to do the work’, ‘inability to get to work’). We also measured three other parameters before and after the experiment: mood state, restoration and vitality. Watching the video from forest area raised mood and restoration and watching the video from urban area, decreased mood, vitality and restoration. The study suggests that watching a video showing forest landscapes could be used as an effective remedy for problems related to procrastination among students.
Patient Satisfaction in the Peruvian Health Services: Validation and Application of the HEALTHQUAL Scale
Authors: Barrios-Ipenza Fernando , Calvo-Mora Arturo , Velicia-Martín Félix , Criado-García Fernando , Leal-Millán Antonio
Published: July 2020

During recent years, public–private partnerships (PPPs) in the health sector have been an attractive alternative for improving healthcare services in developing countries such as Peru. Therefore, it is fundamental to consider a comprehensive set of healthcare qualities, like the HEALTHQUAL scale, when we measure dimensions of healthcare service quality. Currently, no studies have applied HEALTHQUAL in Peruvian hospitals. The purposes of this study were to (1) validate and evaluate the application of the HEALTHQUAL scale to measure user satisfaction in outpatient services at two PPP hospitals in Peru; and (2) test the relationship between user satisfaction, efficiency, and loyalty. A descriptive, cross-sectional study based on the HEALTHQUAL scale was carried out at the end of 2018. The measurement items were satisfaction with healthcare personnel, satisfaction with nonhealthcare personnel, satisfaction with facilities and equipment, perception of efficiency, and trust. The scale was administered to a nonprobability sample of 250 users who attended one of two PPP hospitals—Barton and Kaelin. The application of partial least squares path modeling significantly impacted on the perceived efficiency in the items of healthcare personnel, nonhealthcare personnel, and facilities and equipment. The HEALTQUAL scale demonstrated sufficient validity and thus can be applied for measuring user satisfaction in PPP hospitals.
Extended Reality in Spatial Sciences: A Review of Research Challenges and Future Directions
Authors: Çöltekin Arzu , Lochhead Ian , Madden Marguerite , Christophe Sidonie , Devaux Alexandre , Pettit Christopher , Lock Oliver , Shukla Shashwat , Herman Lukáš , Stachoň Zdeněk , Kubíček Petr , Snopková Dajana , Bernardes Sergio , Hedley Nicholas
Published: July 2020

This manuscript identifies and documents unsolved problems and research challenges in the extended reality (XR) domain (i.e., virtual (VR), augmented (AR), and mixed reality (MR)). The manuscript is structured to include technology, design, and human factor perspectives. The text is visualization/display-focused, that is, other modalities such as audio, haptic, smell, and touch, while important for XR, are beyond the scope of this paper. We further narrow our focus to mainly geospatial research, with necessary deviations to other domains where these technologies are widely researched. The main objective of the study is to provide an overview of broader research challenges and directions in XR, especially in spatial sciences. Aside from the research challenges identified based on a comprehensive literature review, we provide case studies with original results from our own studies in each section as examples to demonstrate the relevance of the challenges in the current research. We believe that this paper will be of relevance to anyone who has scientific interest in extended reality, and/or uses these systems in their research.
Association between High On-Aspirin Platelet Reactivity and Reduced Superoxide Dismutase Activity in Patients Affected by Type 2 Diabetes Mellitus or Primary Hypercholesterolemia
Authors: Barale Cristina , Cavalot Franco , Frascaroli Chiara , Bonomo Katia , Morotti Alessandro , Guerrasio Angelo , Russo Isabella
Published: July 2020

Platelet hyperactivation is involved in the established prothrombotic condition of metabolic diseases such as Type 2 Diabetes Mellitus (T2DM) and familial hypercholesterolemia (HC), justifying the therapy with aspirin, a suppressor of thromboxane synthesis through the irreversible inhibition of cyclooxygenase-1 (COX-1), to prevent cardiovascular diseases. However, some patients on aspirin show a higher than expected platelet reactivity due, at least in part, to a pro-oxidant milieu. The aim of this study was to investigate platelet reactivity in T2DM (n = 103) or HC (n = 61) patients (aspirin, 100 mg/day) and its correlation with biomarkers of redox function including the superoxide anion scavenger superoxide dismutase (SOD) and the in vivo marker of oxidative stress urinary 8-iso-prostaglandin F2α. As results, in T2DM and HC subjects the prevalence of high on-aspirin platelet reactivity was comparable when both non-COX-1-dependent and COX-1-dependent assays were performed, and platelet reactivity is associated with a lower SOD activity that in a stepwise linear regression appears as the only predictor of platelet reactivity. To conclude, in T2DM and HC, similarly, the impairment of redox equilibrium associated with a decrease of SOD activity could contribute to a suboptimal response to aspirin.
Nuclear Receptors, Ligands and the Mammalian B Cell
Authors: Jones Bart G. , Penkert Rhiannon R. , Surman Sherri L. , Sealy Robert E. , Hurwitz Julia L.
Published: July 2020

Questions concerning the influences of nuclear receptors and their ligands on mammalian B cells are vast in number. Here, we briefly review the effects of nuclear receptor ligands, including estrogen and vitamins, on immunoglobulin production and protection from infectious diseases. We describe nuclear receptor interactions with the B cell genome and the potential mechanisms of gene regulation. Attention to the nuclear receptor/ligand regulation of B cell function may help optimize B cell responses, improve pathogen clearance, and prevent damaging responses toward inert- and self-antigens.
Influence of Cover Crop Termination on Ground Dwelling Arthropods in Organic Vegetable Systems
Authors: Depalo Laura , Burgio Giovanni , Magagnoli Serena , Sommaggio Daniele , Montemurro Francesco , Canali Stefano , Masetti Antonio
Published: July 2020

A key aspect in cover crop management is termination before the cash crop is planted. The aim of this study was to assess the effects of termination methods on ground-dwelling arthropods. The conventional mechanical termination method—i.e., green manuring by means of a disc harrow—was compared to flattening using a roller crimper. Two different crop systems were investigated for two growing seasons; cauliflower was grown in autumn after the termination of a mixture of cowpea, pearl millet, and radish, and tomato was cropped in spring and summer after the termination of a mixture of barley and vetch. Ground beetles (Coleoptera: Carabidae), rove beetles (Coleoptera: Staphylinidae), and spiders (Araneae) were sampled by means of standard pitfall traps throughout the growing season of both cash crops. The roller crimper increased the overall abundance of ground beetles in the first growing season of both cash crops, whereas in the second year, no significant effect could be detected. Rove beetles were more abundant in plots where the cover crops were terminated by the roller crimper. Finally, green manuring increased the abundance of spiders, especially on the first sampling date after cover crop termination. Albeit different taxa showed different responses, the termination of cover crops by a roller crimper generally increased the abundance of ground dwelling arthropods. Given that most of the sampled species were generalist predators, their increased abundance could possibly improve biological control.
Cross-Depicted Historical Motif Categorization and Retrieval with Deep Learning
Authors: Pondenkandath Vinaychandran , Alberti Michele , Eichenberger Nicole , Ingold Rolf , Liwicki Marcus
Published: July 2020

In this paper, we tackle the problem of categorizing and identifying cross-depicted historical motifs using recent deep learning techniques, with aim of developing a content-based image retrieval system. As cross-depiction, we understand the problem that the same object can be represented (depicted) in various ways. The objects of interest in this research are watermarks, which are crucial for dating manuscripts. For watermarks, cross-depiction arises due to two reasons: (i) there are many similar representations of the same motif, and (ii) there are several ways of capturing the watermarks, i.e., as the watermarks are not visible on a scan or photograph, the watermarks are typically retrieved via hand tracing, rubbing, or special photographic techniques. This leads to different representations of the same (or similar) objects, making it hard for pattern recognition methods to recognize the watermarks. While this is a simple problem for human experts, computer vision techniques have problems generalizing from the various depiction possibilities. In this paper, we present a study where we use deep neural networks for categorization of watermarks with varying levels of detail. The macro-averaged F1-score on an imbalanced 12 category classification task is 88.3 %, the multi-labelling performance (Jaccard Index) on a 622 label task is 79.5 %. To analyze the usefulness of an image-based system for assisting humanities scholars in cataloguing manuscripts, we also measure the performance of similarity matching on expert-crafted test sets of varying sizes (50 and 1000 watermark samples). A significant outcome is that all relevant results belonging to the same super-class are found by our system (Mean Average Precision of 100%), despite the cross-depicted nature of the motifs. This result has not been achieved in the literature so far.
A Technological Understanding of Biofilm Detection Techniques: A Review
Authors: Achinas Spyridon , Yska Stijn Keimpe , Charalampogiannis Nikolaos , Krooneman Janneke , Euverink Gerrit Jan Willem
Published: July 2020

Biofouling is a persistent problem in almost any water-based application in several industries. To eradicate biofouling-related problems in bioreactors, the detection of biofilms is necessary. The current literature does not provide clear supportive information on selecting biofilm detection techniques that can be applied to detect biofouling within bioreactors. Therefore, this research aims to review all available biofilm detection techniques and analyze their characteristic properties to provide a comparative assessment that researchers can use to find a suitable biofilm detection technique to investigate their biofilms. In addition, it discusses the confluence of common bioreactor fabrication materials in biofilm formation.
Mechanical Properties and Environmental Evaluation of Ultra-High-Performance Concrete with Aeolian Sand
Authors: Chu Hongyan , Wang Fengjuan , Wang Liguo , Feng Taotao , Wang Danqian
Published: July 2020

Ultra-high-performance concrete (UHPC) has received increasing attention in recent years due to its remarkable ductility, durability, and mechanical properties. However, the manufacture of UHPC can cause serious environmental issues. This work addresses the feasibility of using aeolian sand to produce UHPC, and the mix design, environmental impact, and mechanical characterization of UHPC are investigated. We designed the mix proportions of the UHPC according to the modified Andreasen and Andersen particle packing model. We studied the workability, microstructure, porosity, mechanical performance, and environmental impact of UHPC with three different water/binder ratios. The following findings were noted: (1) the compressive strength, flexural strength, and Young’s modulus of the designed UHPC samples were in the ranges of 163.9–207.0 MPa, 18.0–32.2 MPa, and 49.3–58.9 GPa, respectively; (2) the compressive strength, flexural strength, and Young’s modulus of the UHPC increased with a decrease in water/binder ratio and an increase in the steel fibre content; (3) the compressive strength–Young’s modulus correlation of the UHPC could be described by an exponential formula; (4) the environmental impact of UHPC can be improved by decreasing its water/binder ratio. These findings suggest that it is possible to use aeolian sand to manufacture UHPC, and this study promotes the application of aeolian sand for this purpose.
Regularity for Semilinear Neutral Hyperbolic Equations with Cosine Families
Authors: Cho Seong-Ho , Jeong Jin-Mun
Published: July 2020

The purpose of this paper is to obtain the regularity for solutions of semilinear neutral hyperbolic equations with the nonlinear convolution. The principal operator is the infinitesimal generator of a cosine and sine families. In order to show a variation of constant formula for solutions, we make of using the nature of cosine and sine families.
On an Energy-Dependent Quantum System with Solutions in Terms of a Class of Hypergeometric Para-Orthogonal Polynomials on the Unit Circle
Authors: Borrego-Morell Jorge A. , Bracciali Cleonice F. , Sri Ranga Alagacone
Published: July 2020

We study an energy-dependent potential related to the Rosen–Morse potential. We give in closed-form the expression of a system of eigenfunctions of the Schrödinger operator in terms of a class of functions associated to a family of hypergeometric para-orthogonal polynomials on the unit circle. We also present modified relations of orthogonality and an asymptotic formula. Consequently, bound state solutions can be obtained for some values of the parameters that define the model. As a particular case, we obtain the symmetric trigonometric Rosen–Morse potential for which there exists an orthogonal basis of eigenstates in a Hilbert space. By comparing the existent solutions for the symmetric trigonometric Rosen–Morse potential, an identity involving Gegenbauer polynomials is obtained.
In Depth Natural Product Discovery from the Basidiomycetes Stereum Species
Authors: Tian Mengqing , Zhao Peiji , Li Guohong , Zhang Keqin
Published: July 2020

Natural metabolites from microorganisms play significant roles in the discovery of drugs, both for disease treatments in humans, and applications in agriculture. The Basidiomycetes Stereum genus has been a source of such bioactive compounds. Here we report on the structures and activities of secondary metabolites from Stereum. Their structural types include sesquiterpenoids, polyketides, vibralactones, triterpenoids, sterols, carboxylic acids and saccharides. Most of them showed biological activities including cytotoxic, antibacterial, antifungal, antiviral, radical scavenging activity, autophagy inducing activity, inhibiting pancreatic lipase against malarial parasite, nematocidal and so on. The syntheses of some metabolites have been studied. In this review, 238 secondary metabolites from 10 known species and various unidentified species of Stereum were summarized over the last seven decades.
pH-Responsive Properties of Asymmetric Nanopapers of Nanofibrillated Cellulose
Authors: Chemin Maud , Beaumal Baptiste , Cathala Bernard , Villares Ana
Published: July 2020

Inspired by plant movements driven by the arrangement of cellulose, we have fabricated nanopapers of nanofibrillated cellulose (NFC) showing actuation under pH changes. Bending was achieved by a concentration gradient of charged groups along the film thickness. Hence, the resulting nanopapers contained higher concentration of charged groups on one side of the film than on the opposite side, so that pH changes resulted in charge-dependent asymmetric deprotonation of the two layers. Electrostatic repulsions separate the nanofibers in the nanopaper, thus facilitating an asymmetric swelling and the subsequent expanding that results in bending. Nanofibrillated cellulose was modified by 2,2,6,6-tetramethylpiperidin-1-yloxyl radical (TEMPO) oxidation at two reaction times to get different surface concentrations of carboxylic acid groups. TEMPO-oxidized NFC was further chemically transformed into amine-modified NFC by amidation. The formation of graded nanopapers was accomplished by successive filtration of NFC dispersions with varying charge nature and/or concentration. The extent of bending was controlled by the charge concentration and the nanopaper thickness. The direction of bending was tuned by the layer composition (carboxylic acid or amine groups). In all cases, a steady-state was achieved within less than 25 s. This work opens new routes for the use of cellulosic materials as actuators.
The “Conversion” of Anthony Obinna to Mormonism: Elective Affinities, Socio-Economic Factors, and Religious Change in Postcolonial Southeastern Nigeria
Authors: Hurlbut David Dmitri
Published: July 2020

This article analyzes the “conversion” of Anthony Uzodimma Obinna, an Igbo schoolteacher from the town of Aboh Mbaise in Imo State, and his extended family to Mormonism in southeastern Nigeria between the 1960s and the 1980s, from a historical perspective. I argue that the transition of Anthony Obinna and his family away from Catholicism to Mormonism can be explained by both the elective affinities that existed between Mormonism and indigenous Igbo culture, and socio-economic factors as well. This article bases its conclusions on a close reading of oral histories, personal papers, and correspondence housed at the LDS Church History Library in Salt Lake City, Utah and L. Tom Perry Special Collections at Harold B. Lee Library, Brigham Young University in Provo, Utah.
A Soft Computing Approach for Selecting and Combining Spectral Bands
Authors: Albarracín Juan F. H. , Oliveira Rafael S. , Hirota Marina , dos Santos Jefersson A. , Torres Ricardo da S.
Published: July 2020

We introduce a soft computing approach for automatically selecting and combining indices from remote sensing multispectral images that can be used for classification tasks. The proposed approach is based on a Genetic-Programming (GP) framework, a technique successfully used in a wide variety of optimization problems. Through GP, it is possible to learn indices that maximize the separability of samples from two different classes. Once the indices specialized for all the pairs of classes are obtained, they are used in pixelwise classification tasks. We used the GP-based solution to evaluate complex classification problems, such as those that are related to the discrimination of vegetation types within and between tropical biomes. Using time series defined in terms of the learned spectral indices, we show that the GP framework leads to superior results than other indices that are used to discriminate and classify tropical biomes.
Living with Breakthrough: Two-Dimensional Liquid-Chromatography Separations of a Water-Soluble Synthetically Grafted Bio-Polymer
Authors: van de Ven H.C. , Purmova J. , Groeneveld G. , Bos Tijmen S. , Gargano A.F.G. , van der Wal Sj. , Mengerink Y. , Schoenmakers Peter J.
Published: July 2020

In this study, we evaluate the use of various two-dimensional liquid chromatographic methods to characterize water-soluble, synthetically grafted bio-polymers, consisting of long poly(acrylic acid) chains and short maltodextrin grafts. The confirmation of the presence of grafting and the estimation of its extent is challenging. It is complicated by the limited solubility of polymers, their structural dispersity and chemical heterogeneity. Moreover, the starting materials (and other reagents, reaction products and additives) may be present in the product. Reversed-phase liquid chromatography (RPLC), hydrophilic-interaction liquid chromatography (HILIC) and size-exclusion chromatography (SEC) were used to characterize the product, as well as the starting materials. Additionally, fractions were collected for off-line characterization by infrared spectroscopy and mass spectrometry. The one-dimensional separation methods were found to be inconclusive regarding the grafting question. Breakthrough (the early elution of polymer fractions due to strong injection solvents) is shown to be a perpetual problem. This issue is not solved by comprehensive two-dimensional liquid chromatography (LC × LC), but information demonstrating the success of the grafting reaction could be obtained. SEC × RPLC and HILIC × RPLC separations are presented and discussed.
Exploring perspectives on chronic obstructive pulmonary disease in people who smoke heroin: a qualitative study
Authors: Nightingale Rebecca , Griffiths Paul , Mortimer Kevin , Walker Paul , Byrne Tara , Marwood Kerry , Morrison-Griffiths Sally , Renwick Sue , Rylance Jamie , Burhan Hassan
Published: July 2020

Background

Smoking rather than injecting heroin has become more common over the last 20 years. Although there is an increasing body of evidence describing high levels of chronic obstructive pulmonary disease (COPD) in people who smoke heroin, there is limited evidence documenting the impact of the long-term condition on this population group.

Aim

This study aimed to describe the experiences of people who smoke heroin with COPD in Liverpool, UK.

Design & setting

Participants were purposefully sampled for this qualitative study. They included adults enrolled in an opioid replacement clinic run by Addaction in Liverpool, who had already engaged with spirometry testing for COPD as part of a previous study.

Method

Semi-structured interviews were performed with participants with spirometrically confirmed COPD in opioid replacement clinics. Data were analysed using a framework analysis approach.

Results

Sixteen potential participants were invited to take part in the study, of which 10 agreed and were interviewed. Three themes common to all interviews were identified: functional measures of lung health that impacted on their activities of daily living; inhaler and medication perceptions with erratic use that was not concordant with their prescription; and the impact of difficulties accessing care.

Conclusion

These findings, along with previous studies highlighting the prevalence of COPD in this population, warrant efforts to integrate community COPD and opioid replacement services to improve outcomes for this vulnerable population.
Assessment of the Microbiome Role in Skin Protection Against UV Irradiation Via Network Analysis
Authors: Heidari Mohammad Hossein , Razzaghi Mohammadreza , Akbarzadeh Baghban Alireza , Rostami-Nejad Mohammad , Rezaei-Tavirani Mostafa , Zamanian Azodi Mona , Zali Alireza , Ahmadzadeh Alireza
Published: July 2020

Introduction: Diverse microbiotas which have some contributions to gene expression reside in human skin. To identify the protective role of the skin microbiome against UV exposure, proteinprotein interaction (PPI) network analysis is used to assessment gene expression alteration. Methods: A microarray dataset, GEO accession number GSE117359, was considered in this respect. Differential expressed genes (DEGs) in the germ-free (GF) and specific pathogen-free (SPF) groups are analyzed by GEO2R. The top significant DEGs were assigned for network analysis via Cytoscape 3.7.2 and its applications. Results: A total of 28 genes were identified as significant DEGs and the centrality analysis of the network indicated that only one of the seven hub-bottlenecks was from queried genes. The gene ontology analysis of Il6, Cxcl2, Cxcl1, TNF, Il10, Cxcl10, and Mmp9 showed that the crucial genes were highly enriched in the immune system. Conclusion: The skin microbiome plays a significant role in the protection of skin against UV irradiation and the role of TNF and IL6 is prominent in this regard.
Comparison of Antibacterial Effects of Photodynamic Therapy and an Irrigation Activation System on Root Canals Infected With Enterococcus faecalis: An In Vitro Study
Authors: Asnaashari Mohammad , Kooshki Niloufar , Salehi Mohammad Mahdi , Azari-Marhabi Saranaz , Amin Moghadassi Hedieh
Published: July 2020

Introduction: Enterococcus faecalis is a resistant bacterium which is the most abundant species in infected root canals. Photodynamic therapy (PDT) is a method for killing the bacteria with active Oxygen radicals generated in a photosensitizer when exposed to centralized light. Furthermore, as a new method of canal disinfection, a variety of irrigation activation systems have been introduced, one of which is GentleFile (GF) with rotary movements and spiral effects for antibacterial action. This study aimed to compare the effectiveness of the two mentioned methods when used with and without Sodium Hypochlorite in eliminating E. faecalis from infected root canals. Methods: Fifty-eight uniradicular teeth were randomly divided into 4 experimental groups of 14. Two specimens were selected for later scanning electron microscopy in order to screen the procedure steps. In each experimental group, 10 samples were selected to be treated with GF or PDT; 3 of them were selected as positive controls and the other one sample was chosen as a negative control. Experimental groups were as follows: (1) Irrigation activation system, (2) Irrigation activation system + sodium hypochlorite, (3) PDT, and (4) PDT+ sodium hypochlorite. The specimens were then cultured for a bacterial colony count. Results: The decrease in the bacterial count after the treatment with the irrigation activation system was 99.8% (P=0.011) and when the system was used with sodium hypochlorite, it was 100% (P=0.001). The antibacterial effect of PDT was 90.08% (P=0.011) and it was 99.7% when PDT was combined with sodium hypochlorite (P=0.011). Conclusion: All four methods can be administered as complementary methods in root canal disinfection. According to the results of disinfection in the experimental groups of current study it is concluded that integration of new technologies such as activation irrigation system or PDT in Combination with NaOCl ameliorates disinfection of root canal and can provide several advantages in the endodontic outcome.