bluuebunny/crossref_metadata_2025 huggingface dataset:
The impact of an attending intensivist on the clinical outcomes of patients admitted to the cardiac surgical intensive care unit following valvular heart surgery
Authors: Kim Dong Jung , Park You Kyeong , Kim Kang Min , Kim Sang Yoon , Jung Joon Chul , Chang Hyoung Woo , Lee Jae Hang , Kim Jun Sung , Lim Cheong , Park Kay-Hyun
Published: July 2022

Background: We aimed to investigate the impact of an attending intensivist on the clinical outcomes of patients admitted to the cardiac surgical intensive care unit (CSICU) following valvular heart surgery. Methods: Patients who underwent valvular heart surgery between January 2007 and December 2012 (control group, n=337) were propensity matched (1:1) between January 2013 and June 2017 (intensivist group, n=407).Results: During the propensity score matching analysis, 285 patients were extracted from each group. Patients in the intensivist group underwent mechanical ventilation for a significantly shorter time than those in the control group (21.8±69.8 vs. 39.2±115.3 hours, P=0.021). More patients were extubated within 6 h in the intensivist group than in the control group (53.7 vs. 42.8%, P=0.015). The incidence of ventilator-associated pneumonia (1.4 vs. 4.9%, P=0.031), cardiac arrest due to cardiac tamponade associated with post-cardiotomy bleeding (0.4 vs. 3.9%, P=0.002), and acute kidney injury (2.8 vs. 7.7%, P=0.011) in the intensivist group was significantly lower than that in the control group. The 30-day mortality rate of the intensivist group was significantly lower than that of the control group (2.1 vs. 6.7%, P=0.015).Conclusions: Critical care provided in the CSICU staffed by an attending intensivist is associated with a lower 30-day mortality rate and reduced incidence of postoperative complications.
Mining in extremely imbalanced data: a case study for predicting personnel fraud in a bank
Authors: Duman Ekrem
Published: July 2022

One of the rare departments that data scientists have not deal with yet is the Internal Audit department where they inspect and try to find out the bank personnel who might have been committing fraud. The main reason of this is the too few known fraudulent cases and thus an extremely imbalanced data between fraudulent and legitimate transactions. On the other hand, the work of the auditors is too complicated as they touch almost all banking system. In this study, we, for the first time in the literature, apply data analytics tools in a novel framework to help the auditors. The aim is to indicate which transactions, or personnel should the auditors inspect in the first place so that they can figure out problems with a higher chance. To overcome the difficulties related with the extreme imbalance of the data, we suggested and compared two different ideas. First one is making use of descriptive techniques together with the predictive tools. The second one is using a genuine technique to oversample the minority class. The models developed are shown to perform good on past data.
A Comprehensive Study on Gelatin- and Whey Protein Isolate-based Edible Films as Carriers of Fireweed (Epilobium angustifolium L.) Extract
Authors: Kowalczyk Dariusz , Szymanowska Urszula , Skrzypek Tomasz , Basiura-Cembala Monika , Bartkowiak Artur , Łupina Katarzyna
Published: July 2022

The properties of gelatin (GEL) and whey protein isolate (WPI) edible films incorporated with fireweed extract (FE, 0-0.05%) were compared. The GEL films had more crystalline structure, thus were mechanically stronger and less permeable to water vapor than the WPI films. Furthermore, GEL offered more transparent, less yellow, and more stretchable films. In turn, the WPI films had superior UV-protective potential. An increase in the FE concentration yielded films with improved UV-blocking ability. The WPI films incorporated with higher levels of FE (0.025–0.05%) exhibited better antiradical potential in comparison to the GEL films. This result indirectly indicates that the WPI-based films, being more soluble and less swellable, ensured faster release of FE than the GEL films. The slower building up of the antiradical activity of the FE-supplemented GEL films suggests that GEL could be more useful in the development of slow/less migratory active packaging systems for high moisture food.
The genome size estimation and telomeric-repeat motifs of thirteen Arctic plants
Authors: Kim Jun , Kim Moonkyo , Lee Yoo Kyung
Published: July 2022

As a preliminary step of genome analysis, we produced a total of 28–44 Gb DNA sequencing data of whole-genome for thirteen Svalbard plants. We estimated genome sizes using these data with a k-mer-based computation tool and found that genome sizes of eight species ranged from 180–894 Mb: Cochlearia groenlandica 180 Mb, Dryas octopetala 204 Mb, Eriophorum scheuchzeri ssp. arcticum 306 Mb, Oxyria digyna 352 Mb, Salix polaris 383 Mb, Betula nana 689 Mb, Cassiope tetragona 798 Mb, and Silene uralensis ssp. arctica 894 Mb. We could not estimate the genome size of the other five species. We also analyzed variations in DNA sequences by identifying putative telomeric-repeat motifs in the thirteen Svalbard plants. Eleven out of thirteen species contained the canonical plant telomeric-repeat motif, TTTAGGG (Arabidopsis-type), whereas S. oppositifolia contained the Chlamydomonas-type telomeric-repeat motif (TTTTAGGG) and P. dahlianum had a novel telomeric-repeat motif, TTCAGGG. These findings provide a quantitative guideline for whole-genome sequencing analysis of Arctic plants in the future. The findings in this study provide a quantitative guideline for whole-genome sequencing analysis of Arctic plants, and they also show the potential of Arctic plants to be a new source of telomere diversity.
Inhibition of P2X7 receptors by Lu AF27139 diminishes colonic hypersensitivity and CNS prostanoid levels in a rat model of visceral pain
Authors: Staal Roland , Gandhi Adarsh , Zhou Hua , Cajina Manuel , Jacobsen Anne-Marie , Hestehave Sara , Hopper Allen , Poda Suresh , Chandresana Gamini , Zorn Stevin , Campbell Brian , Segerdahl Marta , Moller Thomas , Munro Gordon
Published: July 2022

Visceral pain is a prominent feature of various gastrointestinal diseases. The P2X7 receptor is expressed by multiple cell types including dorsal root ganglion satellite glial cells, macrophages and spinal microglia, all of which have been implicated in nociceptive sensitization. We have used the selective and CNS penetrant P2X7 receptor antagonist Lu AF27139 to explore this receptor’s role in distinct rat models of inflammatory and visceral hypersensitivity. Rats injected with CFA in the hindpaw displayed a marked reduction in hindpaw mechanical threshold, which was dose-dependently reversed by Lu AF27139 (3–30 mg/kg, p.o.). In rats injected with TNBS in the proximal colon, the colorectal distension threshold measured distally was significantly lower than sham treated rats at 7 days post-injection (P < 0.001), indicative of a marked central sensitization. Colonic hypersensitivity was also reversed by Lu AF27139 (10–100 mg/kg) and by the κ-opioid receptor agonist U-50,488H (3 mg/kg, s.c.). Moreover, both Lu AF27139 and U-50,488H prevented a TNBS-induced increase in spinal and brain levels of PGE2 and LTB4, as well as an increase in brain levels of PGF2α and TXB2. Lu AF27139 was well tolerated as revealed by a lack of significant effect on rotarod motor function and coordination at all doses tested up to 300 mg/kg. Thus, P2X7 receptor antagonism is efficacious in a rat model of visceral pain, via a mechanism which potentially involves attenuation of microglial function within spinal and/or supraspinal pain circuits, albeit a peripheral site of action cannot be excluded.
Arsenic Remove from Apatite-Soil Treated Waters’ Using Magnetic Zero Valent Iron Doped Polyethersolfun Beads
Authors: Noorbakhsh Roya , Koohi Mohammad Kazem , Hasan Jalal , Rahmani Anoosheh , Nodeh Hamid Rashidi
Published: July 2022

The drop immerses calcium chloride aqueous solution was utilized to prepare the zero valent iron-doped polyethersulfone beads (PES/ZVI) for efficient removal of arsenic from apatite-soil treated waters’. The proposed beads can assist in promoting uptake efficiency by hindering ZIV agglomeration due to high porosity and different active sites. The PES/ZVI beads were characterized by Fourier transform infrared spectroscopy (FTIR), scanning electron microscopy (SEM), thermogravimetric analysis (TGA), and vibrating sample magnetism (VSM). The objective of this manuscript was to develop new PES/ZVI beads with increased removal efficiency for the removal of arsenic ions from the apatite-soil treated waters’. Maximum arsenic removal of 82.39% was achieved when applied at an 80 mg dose for a contact time of 180 min and 90% after 300 min shaking time. The experimental process was fitted with the Langmuir model due to the high R2 (0.99) value compared to the Freundlich model (0.91) with an adsorption capacity of 41.32 mg.g− 1. The adsorption rate was limited by pseudo-second-order (R2 = 0.999) and the adsorption mechanism nature is endothermic and physical. Hence, isotherm, kinetic and thermodynamic studies revealed the feasibility of sorption and removal of arsenic through the physisorption process.
An Exploratory Study on Learner Agency and Second Language Writing Practices of Korean High School Students
Authors: Jang Jinsil
Published: July 2022

This qualitative study explores Korean English learners’ exercising of agency in processing and producing L2 writing. Data were collected from off-line and online interviews, field notes, and other written materials over the course of two years and analyzed from a social view of agency (Ahearn, 2010; van Lier, 2008). The students’ engagement in varied L2 writing projects and their writing artifacts consistently showed their enhanced awareness of linguistic and other semiotic resources which resulted in their frequent and continuous use of multiple languages and other placed resources. Meanwhile, they developed their strategies and reshaped their L2 writing practices considering the given context, placed resources, and their funds of knowledge. Findings from this study provide valuable insights into the open possibilities of EFL students’ exercise and development of agency, which is an increasingly necessary feature of life-ling learners in the post-pandemic era.
Delayed anterior tibial artery pseudoaneurysm following the corrective fibular osteotomy for knee osteoarthritis - A Case Report
Authors: Chang Chih-Wei , Chen Yu-Sheng , Yang Chyun-Yu , Chen Yen-Nien
Published: July 2022

Introduction: Proximal fibula osteotomy (PFO) has been recognized as a surgical alternative for treating medial compartment osteoarthritis of the knee. Related peroneal neuropathies were concerned despite relatively low complications after PFO. In our clinical practice, a modification of the osteotomy level was thus made without mentioned neurologic deficits. However, a rare case of vascular injury was encountered. Herein we present a rare anterior tibial artery (ATA) psuedoaneurysm after this corrective osteotomy.Case presentation: A 55-year-old male visited our emergent room, presenting a painful swelling over his right antero-lateral shin 13 days post PFO. Radiological investigations showed an ATA pseudoaneurysm and which was solved with endovascular repair.Discussion: The suggested osteotomed level of PFO prone the peroneal neuropathies, which could be avoided by the modified level of osteotomy. Despite similar relief of knee pain, a rare case of vascular complication, ATA psuedoaneurysm, was encountered. Considering the course of ATA, the osteotomy should start at the posterolateral corner of the fibula and aim toward the anterior tibia.Conclusion: Although PFO was a simple surgical procedure, not free of complications. Recent surgical history along with alarming vascular symptoms should arouse clinical suspicion and timely intervention.
Treatment strategies of patients with co-existing TB and LC: systematic reviews and meta-analysis
Authors: zhang hongjun , Li Wen-jie , Chen Yan-wei , Chai Ya-qin , Zhao Yan-jun , Gu Xing
Published: July 2022

Purpose: Treatment strategies of patients with co-existing tuberculosis (TB) and lung cancer (LC) is still not conclusive, especially for advanced non-small cell lung cancer (NSCLC) patients with synchronous or not anti-TB and anti-cancer treatments. This systematic review and meta-analysis aim to assess treatment regimen and arrangement, the efficacy and safety of anti-cancer and anti-TB treatment in NSCLC patients with concomitant active TB.Methods: A Systematic and comprehensive search was performed in the following databases: PubMed, Embase, and Web of Science, in articles and abstracts published from 1929 to 2022. Six articles (involving 261 co-existing TB and LC cases and 8681 LC controls) met the inconclusive criteria. Review Manager version 5.4 (RevMan; Cochrane, Lindon, UK) software and Stata version 17.0 software were used for this statistical analysis.Results: The result of this meta-analysis demonstrates that LC patients with PTB appear to have had poor clinical response to treatment (log OR = 0.32, 95% confidence interval [CI] 0.03 - 0.61, p= 0.03, I2=8.68%). The results showed that lung cancer patients with TB infection had more adverse events (AEs) related to Immune-checkpoint inhibition (ICI), chemotherapy, or target drug treatment (log RR=0.11, 95% CI=0.001–0.02, p= 0.04, I2=38.84%). However, after removing AEs related to ICI treatment, other AEs of any grade were similar in patients with or without PTB treated with chemotherapy or target drug (log RR=0.07, 95% CI=-0.04–0.18, p=0.64, I2=0.00%). Timing to anti-cancer therapy: for 39.0% (102/261) of patients, at least 1-4 weeks after the start of anti-TB therapy; for 3.4% (9/261) of patients, at 2 weeks before the start of anti-TB treatment; for 14.6% (38/261) of patients, at received the anti-TB treatment at the same time.Conclusion: The present meta-analysis demonstrated that LC patients with TB have a poorer treatment response than those without TB; LC patients with TB receiving first-line chemotherapy or targeted therapy and anti-TB treatment at least 1-4 weeks after the start of anti-TB treatment or at the same time will not increase the incidence of AEs.
The Positive Psychological Capital and its Influencing Factors among University Students during the COVID-19 pandemic
Authors: Ren Xiaohong , Wu Dapeng , He Ping , Luo Wenxiu , Zhao Jiayu , cen Yu , Su Keju , Du Chengzhao , Wu Yiyan , Zhu Huaiyi , Wang Xinyue , Yang Liqiu , Xia Lijie , Zeng Runxin , Wen Leling , Zheng Wanli , Yang Yan , Luo Jiaming
Published: July 2022

Background: Little research has been done on the mental health of western Chinese university students during the Coronavirus disease (COVID-19) pandemic. This work aims to fill the gap by gaining insight into the positive psychological capital and its influencing factors among university students in western China during the COVID-19 pandemic. Methods: An online cross-sectional study was conducted in college students from a medical school. Participants were surveyed anonymously using a general information questionnaire and the Positive Psychological Capital Scale. The key factors and models affecting the psychological capital were obtained by using the gradual regression method. If P < 0.05, the difference would be considered statistically significant. Results: The total score of positive psychological capital among university students in western China was 118.51±16.91, Taking the psychological capital as the dependent variable, gender and grade as the independent variables, the key factors and models affecting the psychological capital were obtained by using the gradual regression method.The results showed that the P-value of each influencing factor was <0.05. The key influencing factors of psychological capital of college students were gender and and place of residence. Conclusion: The overall positive psychological capital of college students in western China was in good condition during the pandemic, with large room for improvement though. Gender and Residence were independent influencing factors on the positive psychological capital.
Biotransformation pathway and side reaction engineering for the whole-cell production of glycolic acid from formaldehyde
Authors: Jo Hye-Jin , Yu Hanna , Kim Jun-Hong , Cheon Huijin , Kim Jeong-Sun , Park Jin-Byung
Published: July 2022

A very simple biocatalytic system for the synthesis of the industrially relevant C2 chemicals (e.g., glycolic acid (3)) from formaldehyde (1) was established by whole-cell biocatalyst. The biocatalytic system consisted of an engineered glyoxylate carboligase from Escherichia coli K-12 (EcGCL) and an aldehyde dehydrogenase (e.g., AldA from E. coli K-12). To improve glycolic acid production, we have investigated metabolic engineering to regulate substrate consumption and product bypass and E. coli-based strain optimization. The target compound was produced at rates of up to 20.3 U/g dry cells with conversions up to 92%. This study will ensure the sustainability of the green energy industry by synthesizing valuable C2 chemical from a single carbon compound, formaldehyde.
Proteomic analysis of colon cancer reveals the classical lipogenic pathway has prognostic and therapeutic opportunities
Authors: Srivast Sanjeeva , Barpanda Abhilash , Biswas Deeptarup , Verma Ayushi , Parihari Shashwati , Singh Avinash , Kapoor Shobhna , Kantharia Chetan
Published: July 2022

Despite recent advancements, the high mortality rate remains a concern in colon cancer (CAC). Identification of prognostic markers could prove to be a great asset in CAC management. Our previous work including several other studies has identified de novo lipogenesis (DNL) with increased FASN activity in CAC progression, but only a few have comprehensively investigated its role in disease pathobiology. This study aims to establish the prognostic as well as the therapeutic potential of DNL and associated signaling cascades in CAC. The key lipogenic enzymes FASN and ACLY were quantified using parallel reaction monitoring in tumors along with their matched controls and peptide intensities were used for class prediction analysis. A panel containing 12 unique peptides was identified with the ability to differentiate between CAC and controls with an accuracy of ~0.8. Furthermore, cerulenin-mediated suppression of the DNL in HCT116 cells revealed its multifunctional significance in cancer proliferation and metastasis. The inhibition affected various cellular signaling pathways, including cancer metabolic processes. The study revealed apoptosis induction through the up-regulation of Ub-proteasome machinery upon DNL inhibition. Again, in silico molecular docking-based drug repurposing was performed to find potential drug candidates. Furthermore, we have demonstrated that blocking DNL could be explored as a therapeutic option in CAC treatment.
A phase III study of HR-positive/HER2-negative and lymph node-positive breast cancer non- responsive to primary chemotherapy: a randomized clinical trial
Authors: Yang Yang , He Yingjian , Fan Zhaoqing , Chen Xue , Liu Yiqiang , Zhang Chao , Jiang Hongchuan , Wang Xin , Wang Xiang , Xie Fei , Wang Shu , Luo Bin , Kang Hua , Wang Tao , Jiang Zefei , Yuan Peng , Xu Binhe , Xu Ling , Liu Yinhua , Li Jinfeng , Xie Yuntao , Wang Tianfeng , Ouyang Tao
Published: July 2022

Background: We evaluated the use of pathological response-guided non-cross-resistant adjuvant chemotherapy in patients with hormone receptor-positive (HR+)/human epidermal growth factor receptor 2-negative (HER2-)/lymph node-positive (LN+) breast cancer who were non-responsive to primary chemotherapy.
Methods: A multi-center, open-label, randomized, controlled phase III trial was conducted. Patients with HR+/HER2−/LN+ breast cancer and non-responsive to four cycles of neoadjuvant chemotherapy (Miller and Payne grade (G) 1 to G3 or any Miller and Payne grade but with residual positive lymph nodes in surgical specimens) were randomly assigned to receive four cycles of non-cross-resistant regimen plus endocrine therapy, or endocrine therapy alone. Patients with Miller and Payne G4 or G5 and LN− status were assigned to the observation group. Distant disease-free survival was the primary endpoint.
Results: Of the 433 patients enrolled between October 2010 and September 2018, 391 were non-responsive to treatment, and the final intention-to-treat analysis comprised 379 patients (chemotherapy plus endocrine therapy group, n=187; endocrine therapy-alone group, n=192). Forty patients responsive to neoadjuvant chemotherapy were assigned to the observation group. After a median follow-up period of 72.4 months, the 5-year distant disease-free survival was 92% (95% confidence interval [CI], 88–96%) and 90% (95% CI, 86–94%) in the chemotherapy plus endocrine therapy and endocrine therapy-alone groups, respectively (hazard ratio 0.79, 95% CI 0.45‒1.37; P=0.401). There was no significant difference between any of the prespecified subgroups. Compared to these two randomized groups, the observation group showed a trend towards better distant disease-free survival (P=0.107).
Conclusions: For patients non-responsive to neoadjuvant chemotherapy, adjuvant non-cross-resistant chemotherapy did not significantly improve distant disease-free survival compared to endocrine therapy alone. Trial registration: The trial was registered on November 25, 2009, at ClinicalTrials.gov, and the registration number was NCT01019616. https://clinicaltrials.gov/ct2/show/NCT01019616?term=alternative+non-cross-resistant&draw=2&rank=1
Drivers of Bilateral Climate Finance Aid: The Roles of Paris Agreement Commitments and Public Governance
Authors: Yuan Cheng , Xuehui Han
Published: July 2022

Using granular data from the OECD from 2010 to 2018 that differentiate between adaptation and mitigation measures to address climate change, we employed a double-hurdle model to examine whether countries’ Paris Agreement commitments and governance capacity help attract international climate-change-related financial aid. We found that (i) countries received a short-term aid boost in the year when they submitted the nationally determined contribution, and countries that committed only to action targets rather than emission goals were more likely to receive funds; (ii) both the quality of the budget and financial management and the quality of public management significantly enhanced the likelihood of receiving aid, but only the quality of public management contributed to attracting funding for adaptations; and (iii) multilateral institutions played catalytic roles in fostering bilateral international climate-change aid, particularly by increasing the likelihood of funding.JEL: O13; O19; Q54; H83.
Clinical study to verify the effectiveness and safety of the modified isothymol or carvacrol compound against SARS-CoV-2 in COVID-19 patients
Authors: OJEDA RAUL A
Published: July 2022

BACKGROUNDAlthough several therapeutic agents have been evaluated for the treatment of coronavirus disease 2019 (COVID-19), none have yet been shown to be efficacious.METHODSWe conducted a double-blind, randomized, placebo-controlled trial of isothymol in adults hospitalized with Covid-19 with evidence of lower respiratory tract involvement. Patients were randomly assigned to receive either isothymol (6mg/ml) or placebo for up to 15 days. The primary outcome was the time to recovery, defined by either discharge from the hospital or hospitalization for infection-control purposes only.RESULTSA double-blind, randomized, controlled trial with placebo and modified isothymol was conducted in adults who were hospitalized with COVID-19. Patients were randomized to receive isothymol (6 mg/ml) or placebo for up to 15 days. The primary outcome was recovery time, defined by discharge from the hospital. The results of the 600 patients (300 assigned to isothymol and 300 to placebo) with data available after randomization suggest that those who received isothymol had a median recovery time of 7 days (95% confidence interval [CI], 5 to 9), compared with 14 days (95% CI, 11 to 15) in those who received placebo (recovery rate ratio, 1.24; 95% CI, 0.78 to 1.87; P <0.001). The Kaplan-Meier estimates of mortality at 15 days were 0% with isothymol and 4% with placebo. No serious adverse events were reported in patients in the isothymol group who underwent randomization and in 13 of the 300 patients in the placebo group who underwent randomization (4.33%). Ex vivo analysis of blood plasma shows a close relationship between hypersensitivity of inflammatory mediators (macrophages and type I interferons) and significantly elevated histamine production, as evidenced by autophosphorylation and increased IL-6 production in blood monocytes. of patients with severe COVID-19 compared to blood monocytes from healthy volunteers.CONCLUSIONSIsothymol was superior to placebo in shortening the time to recovery in adults hospitalized with Covid-19 and evidence of lower respiratory tract infection. (Funded by the Venezuelan Institute for Scientific Research, IVIC; ISRCTN Registry number, ISRCTN15363958.)
PU Adjacent Subcarriers Power Allocation for Controlling Interference of OFDM-CR Systems
Authors: Bepari Dipen , MONDAL SOUMEN , Chattopadhyay Ananya
Published: July 2022

Interference is the primary limiting factor of Cognitive Radio (CR) systems. This paper proposes a new power allocation idea for orthogonal frequency division multiplexing (OFDM)-based CR systems to control the interference to the licensed primary users (PUs) caused for allowing cognitive users (CUs) to use a licensed band temporarily. The idea is redistribute the power among a minimum number of PU adjacent subcarriers’. This idea has been implemented to modify two existing power loading schemes, and developed an evolutionary Genetic Algorithm (GA)-based power distribution method for maximizing CR system capacity of (i) a single PU, and (ii) multiple PUs CR paradigm under the constraint of total power budget, individual sub-channel power budget and, PU interference tolerance limit. Simulation results authenticated that the CU capacity improvement significantly depends on channel gain quality (good’ or bad’) of the PU adjacent subcarriers.
Majas Perbandingan pada Novel Ingkar Karya Boy Candra (Kajian Stilistika)
Authors: Purnama Yogi , Anam Ahmad Khairul , Mulyani Sri
Published: July 2022

The purpose of this study is to interpret the types of comparative compounds in the novel Ingkar by Boy Candra. This research uses qualitative description research methods. The study as a whole utilizes interpretation in presenting data in descriptive form. The research methods in this study use documentation techniques. The instrument in this study is the researcher himself as a human instrument. The results of comparative compound findings in the novel Ingkar by Boy Candra found as many as 250 data with comparative comparison of parables as many as 68 sentences (27.2%), metaphorical majas as many as 27 sentences (10.8%), majas personification as many as 62 sentences (24.8%), majas depersonification as many as 40 sentences (16%), allegory majas as much as 12 sentences (4.8%), antithesis majas as many as 22 sentences (8.8%), majas pleonasme and tautology as many as 11 sentences (4.4%), majas perifrasis as many as 3 sentences (1.2%), and majas anticipation as many as 5 sentences (2%). Majas comparison is dominant in the novel Ingkar by Boy Candra, which is a comparison of parable categories as much as 68 sentences with a percentage of 27.2%.
Pembelajaran Menulis Teks Prosedur Menggunakan Model Discovery Learning pada Siswa Kelas XI SMK Negeri 2 Kediri
Authors: Ramdani Putra Chelya Ilham , Aisiyah Binti Nasiatul , Sujarwoko Sujarwoko , Puspitoningrum Encil
Published: July 2022

The low skill of writing procedural texts in class XI students at SMK Negeri 2 Kediri is the problem behind this research. Students who tend to be passive result in educational goals in general being less achievable. One of the important things that causes this problem to arise is the lack of interest of students to take an active role in the learning process. From the problems that arise, the author intends to provide a solution that can be applied, namely using the discovery learning learning model in learning to write procedure texts. This study uses an experimental quantitative research model. The population in this study were students of class XI SMK Negeri 2 Kediri. The sample of this study consisted of an experimental class, namely class XI Multimedia 1, and a control class, class XI Accounting 1. The stages of this research were divided into three, namely initial test, test, and final test. The author hopes that this research can be a source of reference for educators in accordance with the results obtained in the study.
Gıda İsrafı, Gıda Kaybı ve Gıda Atığı Üzerine Kavramsal Bir İnceleme (A Conceptual Study on Food Wastage, Food Loss and Food Waste)
Authors: Tahmaz Gül Seçil , Aksoy Mustafa
Published: July 2022

İnsan tüketimi amacıyla üretilen ancak çeşitli nedenlerle insan tarafından tüketilemeyen her gıda, dünya çapında büyük bir problemdir. Gıdanın insan tüketiminden çıkması, birbirini takip eden, farklı özelliklere sahip, çeşitli aşamalardan oluşan ve oluştuğu aşamaya göre kavramsallaştırılan uzun bir süreçtir. Kademeli bir kavramsal örüntüyle ifade edilmeye çalışılan bu süreci oluşturan her aşamanın doğru kavramlarla tanımlanması; problemin doğru tanımlanması, dolayısıyla çözümlerin doğru üretilmesi için son derece önemlidir. Bu nedenle bilimsel çalışmalarda, bu aşamalarla ilgili ortak kavramsal yapının oluşturulabilmesi ve kullanılabilmesi çok değerlidir. Uluslararası literatürde genel olarak ortak bir kavramsal yapının temel alındığı ancak Türkçe literatürde söz konusu yapıyı oluşturan kavramlarla ilgili bir karmaşanın ortaya çıkabildiği ve kavramların birbirleri yerine kullanılabildiği görülmektedir. Doküman analizi yöntemiyle gerçekleştirilen bu çalışmada, kavramların tanımlarının yapılıp aralarındaki ilişkilerin ve farklılıkların karşılaştırmalı olarak ortaya konulması ile söz konusu kavramsal yapının oluşturulmasına katkı sağlanması amaçlanmaktadır. Yapılan inceleme sonucunda elde edilen bulgular, gıda israfının üst kavram olduğunu; gıda kaybı ile gıda atığının bu üst kavrama ait iki alt bileşen olduğunu göstermektedir.
Eko Gastronomi ve Sürdürülebilir Gastronomi (Eco Gastronomy and Sustainable Gastronomy)
Authors: Gün Serkan , Kılıç Gül Damla
Published: July 2022

Günümüzde yiyecek sistemleri, endüstriyel üretim ile özdeşleşmekte bununla beraber sosyal, ekolojik ve ekonomik yönden savunmasız hale geldiği söylenebilir. Gastronomin ise yiyeceğin üretimi, üretiminde kullanılan malzemeler, ekonomik boyut, depolama, taşınma, hazırlanma, yiyeceğin sosyal yönü ve ekonomik etkileri, kültür ve gelenekleri de içeren çok boyutlu bir kavram olarak ele alınabilir (Santich, 2004). Meydana gelen nihai ürünün özellikleri bu ağın isteklerine bağlı olarak oluşmaktadır. Kalite, lezzetli ve sağlıklı ürünler yemek ve yiyecek hakları herkesin en temel hakkıdır. Eko gastronomi, yemeklerin içeriklerin seçilmesinde, hazırlanmasında ve pazarlamasında çevresel kaygıların ön planda olduğu gastronomi uygulamaları olarak tanımlanabilir. Eko gastronomi sürdürülebilir gelişmeleri gastronomi alanında da uygulamayı içermektedir. Sürdürülebilirlik sadece ekonomik göstergeleri dikkate almayı değil aynı zamanda da çevresel ve sosyal etkileri de dikkate almaya içermektedir. Eko-gastronomi, yerel üreticiyi destekleme, ev yapımı lezzetleri gelecek kuşaklara aktarma ve böylece turizme gastronomi faaliyetleriyle katma değer sağlayarak yerel refah düzeyini arttırma gibi konuları içermektedir. Bu bağlamda sürdürülebilirlik anlayışı içerisinde gastronominin boyutları fiziki süreçler, sosyo-kültürel boyutu ve ekonomik boyutu şeklinde ele almak mümkündür. Bu çalışma kapsamında gastronomi, eko gastronomi ve sürdürülebilirlik kavramları üzerinde durularak birbiriyle ilişkileri incelenecektir.
Temel Beceriler Odağında Orta Öğretimde Gastronomi Eğitimi (Gastronomy Education in Secondary Education with a Focus on Basic Skills)
Authors: Çalışkan Serkan
Published: July 2022

Çalışma orta öğretim düzeyinde verilen gastronomi eğitiminin güncel gelişmeler doğrultusunda incelenmesini amaçlamaktadır. Araştırma nitel yöntemlerden doküman incelemesi yöntemiyle gerçekleştirilmiştir. Bu bağlamda çalışma mesleki ve teknik orta öğretim kurumlarında yiyecek içecek hizmetleri alanı eğitimini konu edinmektedir. Milli Eğitim Bakanlığı mesleki eğitimde kullanılan öğretim programlarını 2020 yılında temel beceriler odağında güncellemiştir. Milli Eğitim Bakanlığı’na bağlı Mesleki Teknik Anadolu Liseleri ve Çok Programlı Anadolu Liselerinde gastronomi eğitiminin yiyecek içecek hizmetleri alan ve dalı içerisinde bütüncül bir yaklaşımla ele alındığı dikkat çekmektedir. Örgün eğitim kapsamına alınan mesleki eğitim merkezlerinde ise yiyecek içecek hizmetleri eğitimi altı farklı dalda gerçekleşmektedir. Tüm bunlar ışığında temel becerilerin uygulamalı olarak aktarılmasını hedefleyen mesleki eğitime kaynaklık eden öğretim programları ile orta öğretim düzeyinde verilen gastronomi eğitiminde değişiklikler olduğu söylenebilir.
Gastronomi Envanteri Oluşturulması: Gastronomi Şehri Afyonkarahisar Örneği (Creating Gastronomy Inventory: City of Gastronomy Afyonkarahisar Case)
Authors: Mutlu Hülya , Sandıkçı Mustafa
Published: July 2022

Bu araştırmanın amacı, Afyonkarahisar’ın gastronomi envanterinin oluşturulmasıdır. Araştırmanın evrenini, Afyonkarahisar’ın gastronomi değeri taşıyan köyler ve beldeleri oluşturmaktadır. Araştırma kapsamında yarı yapılandırılmış görüşme tekniği kullanılarak katılımcılara 13 adet açık uçlu soru yöneltilmiştir. Çalışmanın amaçları doğrultusunda, katılımcılardan elde edilen verilerle ana temalar ve alt temalar tanımlanarak MAXQDA 2020 Programı aracılığıyla analiz edilmiştir. Araştırma sonuçlarına göre Afyonkarahisar, farklı etnik grupları bünyesinde barındıran zengin mutfak kültürüne sahip bir şehir olmakla birlikte, her köy ve beldede yemek kültürü değişkenlik göstermektedir.
Evaluation of Tourism Undergraduates 21st Century Learner Skills Usage from Pedagogical Perspective
Authors: Uysal Davut , Kılıç İlker
Published: July 2022

This article aims to measure the level of tourism undergraduates' 21st-century learner skills usage and compare their skills based on the variables of gender and department. The research data was gathered from tourism faculties in Turkey through the convenience sampling method. 411 tourism undergraduates from four different departments completed the research questionnaire. According to research findings, tourism undergraduates use 21st-century learner skills and four subdimensions (cognitive, collaboration, autonomous and flexibility and innovative skills) above midlevel. It was also found that tourism undergraduates’ usage of 21st-century learner skills significantly differed based on the department variable; however, it did not differ based on the gender variable. In addition to these, tourism guidance undergraduates’ 21st-century learner skills usage significantly differed from that of gastronomy undergraduates in the “General 21st-century learner skills usage”, factors of “Cognitive Skills” and “Innovative Skills”. However, they were found not to have differed in the factors of “Collaboration and Flexibility” and “Autonomous Skills”.
Konaklama İşletmelerinde Yapay Zekâ ve Robotik Teknolojileri: Bibliyometrik Bir Analiz (Artificial Intelligence and Robotic Technologies in Lodging Properties: A Bibliometric Analysis)
Authors: Çuhadar Murat , Demiray Gökhan , Öztürk Mertcan , Alabacak Cengizhan
Published: July 2022

Yapay zekâ, son yıllarda en hızlı büyüyen teknolojilerden biri haline gelmiştir. Yaşanan bu gelişmeler, yapay zekâ ve alt alanı olarak robotik uygulamalarının kullanım alanlarının genişlemesine ve çeşitlenmesine vesile olmuştur. Son yıllarda yapay zekâ ve robot teknolojilerinin faydalanılmaya başladığı alanlar arasında turizm sektörü ve özellikle turizm sektörünün önemli bir kolu olan konaklama işletmelerinin geldiği görülmektedir. Bu çalışmada, konaklama işletmeciliği alanında gerçekleştirilen yapay zekâ ve robotik sistemleri konulu çalışmaların detaylı literatür analizi sunulmuştur. Araştırma kapsamında incelenen çalışmalar, Web of Science (WoS) akademik/bilimsel veri tabanı kayıtları taranarak elde edilmiştir. Detaylı taramalar neticesinde, nihai olarak araştırma kapsamında olduğu değerlendirilen 117 adet çalışma analiz edilmiştir. Bu araştırmadan elde edilen bulgular, turizm ve konaklama işletmeciliği alanında yapay zekâ ve robot teknolojileri konularında kaleme alınan çalışmalar hakkında çeşitli ipuçları sağlamaktadır. Alanyazında konuyla ilgili bibliyometri esasına dayalı bilimsel çalışmaların sınırlı sayıda olduğu göz önünde bulundurulduğunda, yazarlarca bu çalışmanın disiplinler arası turizm yazınına katkı sağlaması umulmaktadır.
Analysis of Hospital Pharmacists’ Interventions in a Covid -19 Isolation Centre of a Tertiary Hospital in Ghana
Authors: Ofei-Palm Charles
Published: July 2022

Coronavirus disease 2019 (Covid-19) is a global pandemic that was first identified in the city of Wuhan, China, and declared On January 30, 2020, by the World Health Organization (WHO) as a Public Health Emergency of International Concern. In Ghana, the Korle Bu Teaching Hospital became one of the designated sites for the management of Covid-19 patients, and the pharmacists were part of the task force. This study aims to analyze hospital pharmacists’ interventions in a Covid-19 isolation center and to identify the evidence that supports the effect of such interventions. This was a retrospective study carried out by collecting and collating the interventions and recommendations made by the hospital pharmacists who worked at the isolation center from May 2020 to August 2020 at the peak of the pandemic. A total of 145 pharmacists’ interventions (PIs) were captured from the medication reviews of 53 patients: resulting in an average PI rate of 3 interventions per patient. Women accounted for 58.5% (31/53) of positivity in the study. The mean (SD) for age was 47.1(17.9). Physicians’ acceptance rate of PIs for Covid-19-positive patients was 95.2% (138/145). The most prevalent type of PIs was discharge counseling; 32.4 % (47/145), followed by untreated indication 10.3% (15/145), drug /dose omission 9% (13/145), and drug shortage/refill 9% (13/145) respectively. This study highlights the clinical relevance of pharmacists’ interventions in the Covid-19 era and the importance of teamwork to prevent medication errors.
The Associations between Mental Health Literacy and HIV-related Treatment Outcomes among HIV/AIDS Outpatients in Vietnam
Authors: Tat Thanh Nguyen
Published: July 2022

Data about mental health literacy and its associations with HIV-related treatment outcomes are both sparsely reported and presented with disparate results. This study aimed to assess the mental health performance among HIV/AIDS outpatients and examine the correlations between Mental Health Literacy Scale (MHLS) with some pre-specified HIV-related treatment outcomes, including clinical status, HIV-RNA suppression, antiretroviral (ART) failure, and treatment adherence. We conducted a single-center, cross-sectional study between June and October 2020 in Ho Chi Minh City, Vietnam. Adult HIV-infected patients were enrolled in the study when they routinely attended an outpatient clinic to receive medical consultations and antiretroviral therapy. Bivariate logistic regressions were used to study the associations between MHLS and major HIV-related health outcomes. A total of 406 HIV-infected participants were enrolled during the study period. The median MHLS among HIV/AIDS patients was 99 (Interquartile range (IQR): 93-107). Roughly 93% of patients were clinically stable, with a median CD4 count of 603 cells/µl. Two-thirds of patients achieved HIV-RNA suppression (undetectable threshold < 20 copies/ml). A total of thirteen (3.2%) patients were undertaking protease-inhibitors-based second-line ART regimens. The ART compliance of participants was evaluated at 92.1%. The logistic bivariate analyses did not show any significant correlations between mental health literacy with both pre-specified HIV-related health outcomes and ART adherence. The mental health performance among the HIV/AIDS outpatients at the HIV community-based clinic was at the intermediate level. The mental health literacy of patients was not statistically associated with the pre-specified HIV treatment outcomes.
An Investigation into the Knowledge and Practices of Women towards Menopause in Choma District
Authors: Haambozi Cathrine
Published: July 2022

Menopause is a biological event characterized by a complexity of factors. On average one, third of the women’s life consists of the post-menopause years, and health care programs for women do not address concerns beyond reproductive ages. The purpose of this study was to investigate into the knowledge and practices of women towards menopause in choma district. A descriptive cross-sectional research design was used to collect data from a sample of 50 women from two clinics. The researcher used a questionnaire that included both structured and open-ended questions. The findings indicated that 14(28%) of the respondents had adequate knowledge, while 36(72%) had inadequate knowledge towards menopause. 24(48%) of the respondents had good practices with adequate knowledge on menopause which was statistically significant (P<0.000). In this study, 37(74%) of the respondents who had bad practices had bad health-seeking behaviour. A high proportion of women are affected by menopause related symptoms. Care seeking for all symptoms is not uniform, indicative of a lack of knowledge about the treatable nature of many of these symptoms. There is a need to continue giving health education to women 45 years and above on the signs and symptoms, treatment needed, and where and when to seek health services so as to impart knowledge on menopause.
Financial Limitations and Economics of Survival - Predictors of Adolescent Pregnancies: Evidence from Teenage Boys and Girls in Luuka District, Uganda
Authors: Kabwigu Samuel
Published: July 2022

The purpose of this article is to demonstrate evidence that adolescents, particularly girls, experience financial challenges. And such financial limitations are predictors for adolescent pregnancy. Through a case-control study design, research was conducted in Luuka district, Uganda, to examine predictors of adolescent pregnancy. Mixed methods were used to collect qualitative and quantitative data. This article is written from the qualitative data collected through key informant interviews, in-depth interviews, and focus group discussions with health practitioners, parents, community leaders, and adolescents. Findings show that due to financial limitations in the community and in their families, adolescent girls are affected at a personal level. Consequently, as a means to find a solution to their financial needs, some take on petty trade, others transactional sex as personal survival strategies. These adopted strategies instead expose them to greater vulnerability, making the financial circumstances a predictor for adolescent pregnancies.
Challenges and Opportunities Associated with Solid Waste Management in Chililabombwe District, Zambia
Authors: Sakanyi Gift
Published: July 2022

The management of municipal solid waste (MSW) is a serious challenge facing major environmental challenges associated with waste generation and inadequate waste collection, transport, treatment, and disposal. The paper wishes to highlight on the current waste management practices by the district, also highlighting on challenges and opportunities in order to remedy the current problems and how best to address future opportunities for a better sustainable solid waste management in the district. The district has no capacity to overcome the amplification of the increased generated waste with the increased population, and this has impacted on the environment and public health. The current district aims to move away from the reliance of the open dumpsite that does not offer any environmental protection to a solid waste system that is of more useful that will retain useful resources within the economic zone through recycling. Waste sorting and segregation at the source that provides separation of the recyclable materials is actually key to waste management. Most of the extracted materials from the disposal residuals require proper landfill management with waste sorting facilities. Obviously, challenges and barriers are significant so are the opportunities in the district. Shortage of qualified manpower, lack of technologies, and proper solid waste equipment to deliver improved waste management systems remain the authority concern. Landfill plays a significant role in energy generation if well managed, thus poses a greater opportunity for local empowerment and job creation for the youths that need further study.
Puntos de apoyo mariológicos a la luz de algunos versos del Canto XXXIII de la Divina Comedia.
Authors: Zambruno Pablo
Published: July 2022

Ensayo académico
Carbon Dots from Pilosocereus gounellei for Fluorimetric Determination of Tannin in Tea Using a Flow-Batch System
Authors: Silva Kelly , Andrade Stéfani , Lima Marcelo , Monte-Filho Severino , Araújo Mário , Lima Ricardo
Published: July 2022

In this study, xiquexique (Pilosocereus gounellei) native endemic cactus from the Brazilian semiarid was used for the first time as a natural carbon source (“green precursor”) for the synthesis of highly fluorescent carbon dots (CDs). These CDs were successfully used to develop a fast, low-cost, eco-friendly fluorescence method for the determination of tannins in teas. This method was automatized employing a flow-batch system coupled to an inexpensive ultraviolet light-emitting diode (UV-LED) used as an excitation source and a cheap handheld spectrometer used as a detector. CDs were characterized by transmission electron microscopy (TEM), X-ray diffraction (XRD), Fourier transform infrared spectroscopy (FTIR), UV-Vis, and fluorescence spectroscopy. The proposed method presented a linear range from 2.0-30.0 mg L−1, relative standard deviation (RSD) < 3.0%, limit of detection (LOD) = 0.102 mg L–1, and recovery rates from 90.5-109.1%. A paired t-test at a 95% confidence level indicated no statistically significant difference between the proposed and reference methods, revealing that it is a useful alternative for the determination of tannins.
Modern biophysical view of electromagnetic processes of the phenomenon of life of living biological systems as a promising basis for the development of complex medicine: the role of cell membranes
Authors: Nevoit Ganna , Bumblyte Inga Arune , Potyazhenko Maksim , Minser Ozar
Published: July 2022

The results of a theoretical study of the role of cell membranes in electromagnetic generation and in the process of realizing the phenomenon of life are presented in the article. The aim of the theoretical study was to summarize the existing scientific physical and biological knowledge of modern science about the electromagnetic processes of the phenomenon of life at the cellular level in order to deepen the fundamental knowledge of complex medicine. This study is a fragment of research work on “The development of algorithms and technologies for implementing a Healthy Lifestyle in patients with Noncommunicable Diseases based on the study of functional status” (state registration number 0121U108237: UDC 613 616-056-06: 616.1/9-03). General scientific methods and theoretical methods were used in this theoretical study. The main conclusions of the theoretical study were made as follows: 1) Cell membranes can be considered one of the main morphological structures of electromagnetic generation at the cellular level. 2) Cell viability is ensured by electromagnetic generation and electromagnetic generation of cells can be considered as a separate important function of membranes in addition to those already defined, as it provides signaling. 3) The end result of electromagnetic generation of cell membranes and all molecules of the cell is its own electromagnetic fields, which have a millimeter wavelength range with a frequency of 1010-1011 Hz and they are a quantum mechanical result of electromagnetic generations, perform the information-energy function in intercellular interaction in vivo.