bluuebunny/crossref_metadata_2025 huggingface dataset:
Pengaruh Sarana dan Prasarana terhadap Hasil Belajar IPA Siswa Kelas VIII SMPI Islam Luqman Al Hakim Batam
Authors: Siregar Isropil , Farida Asmira
Published: October 2023

Dalam dunia pendidikan sarana prasarana sangat penting karena sebagai alat penggerak suatu pendidikan. Untuk itu pentingnya melengkapi dan melakukan perbaikan dalam sarana dan prasarana agar hasil belajar siswa meningkat. Tujuan dari penelitian ini untuk mengetahui adanya pengaruh dan seberapa besar pengaruh sarana dan prasarana terhadap hasil belajar IPA. Jenis penelitian ini adalah kuantitatif. Populasi penelitian ini adalah seluruh siswa kelas VIII yang berjumlah 160 orang dan sampel sebanyak 30 orang. Pengumpulan data dilakukan dengan observasi, angket, dan wawancara. Untuk pengambilan data lainnya dilakukan dengan dokumentasi. Teknik analisis data dilakukan dengan menggunakan uji normalitas, uji regresi linear sederhana dan uji koefisien determinasi. Berdasarkan hasil uji regresi linear sederhana diperoleh nilai sig. 0,000 < 0,05, sehingga Ho ditolak yang artinya Ha diterima. Jadi, sarana prasarana berpengaruh positif terhadap hasil belajar siswa. Adapun besarnya pengaruh sebesar 60,2% dan 39,8% dipengaruhi oleh faktor lain.
Pengaruh Penggunaan Media Audio Visual Terhadap Motivasi Belajar Siswa Mata Pelajaran IPA Pada Pembelajaran Daring di SD Islam Integral Luqman Al-Hakim 02 Batam
Authors: Faizah Enik Nur , Sari Ponita
Published: October 2023

Tujuan penelitian ini adalah untuk mengetahui adakah pengaruh penggunaan media audio visual terhadap motivasi belajar siwa mata pelajaran IPA kelas IV pembelajaran daring SD Islam Integral Luqman Al-hakim Batam. Jenis penelitian ini adalah penelitian kuantitatif dengan menggunakan data primer yang dikumpulkan melalui penyebaran angket. Populasi pada penelitian adalah seluruh siswa kelas IV dengan teknik pengambilan sampel jenuh. Analisis instrument pada penelitian ini menggunakan uji validitas dan reliabilitas. Hasil analisis data dengan uji normalitas, homogenitas, dan hipotesis. Hasil uji hipotesis diketahui bahwa nilai t hitung sebesar 6,163 dengan sig. = 0,000, oleh karena nilai sig. < 0,05 maka Ho ditolak yang artinya penggunaan media audio visual berpengaruh positif terhadap motivasi belajar siswa.
ห้องแห่งเสียงสะท้อนออนไลน์กับผู้ออกเสียงเลือกตั้งครั้งแรกในการเลือกตั้งทั่วไป พ.ศ. 2562
Authors: รามสูต พิรงรอง , ไชยนันท์ พิมลพรรณ , สุทธิสีมา วิโรจน์
Published: October 2023

การวิจัยนี้มีวัตถุประสงค์ เพื่อ 1) สำรวจภาวะห้องแห่งเสียงสะท้อนจากการสื่อสารทางการเมืองในพื้นที่ออนไลน์ของผู้ออกเสียงเลือกตั้งครั้งแรก ในช่วงของการเลือกตั้งทั่วไป พ.ศ.2562 2) ศึกษาความสัมพันธ์ระหว่างภาวะของห้องแห่งเสียงสะท้อนในพื้นที่ออนไลน์กับทัศนคติทางการเมือง 3) ศึกษาปัจจัยที่ส่งผลต่อภาวะห้องแห่งเสียงสะท้อน โดยใช้พหุวิธีวิจัย การศึกษาพบว่าองค์ประกอบหนึ่งของห้องแห่งเสียงสะท้อนในแง่ข้อมูลหรือชุดความคิดหลักหนึ่ง ๆ ได้รับการตอกย้ำและกระจายออกไปผ่านการทำซ้ำและการสนับสนุนในกลุ่มแบ่งขั้ว ส่วนลักษณะการกลั่นกรองและคัดสรรข้อมูลโดยระบบอัลกอริทึมพบในบางวิธีศึกษา ขณะเดียวกัน ภาวะห้องแห่งเสียงสะท้อนมีความสัมพันธ์กับทัศนคติทางการเมืองของบุคคล ซึ่งสร้างภูมิทัศน์ทางความคิดรายรอบแต่ละบุคคลเอาไว้ เมื่อผนวกกับประเด็นเรื่องปัจจัยทางเทคโนโลยีและการรวมกลุ่มสังคมจะทำให้เกิดการสร้าง “พื้นที่ทางความคิด” ขึ้นมา สำหรับปัจจัยที่ส่งผลต่อภาวะห้องแห่งเสียงสะท้อนในการวิจัยนี้ ได้แก่ 1) อัลกอริทึมสร้างภาวะฟองสบู่ตัวกรอง 2) แนวทางในการเปิดรับข้อมูลข่าวสารทางการเมืองของผู้ใช้ออนไลน์ 3) ทัศนคติทางการเมืองและบริบท/สถานการณ์แวดล้อมทางการเมือง และ 4) รูปแบบเครือข่ายทางการสื่อสารที่มีส่วนร่วมในพื้นที่ออนไลน์
การวิเคราะห์เชิงสถาบันของระบบเตือนภัยล่วงหน้าสำหรับอุทกภัยในประเทศไทย: กรณีศึกษา อุทกภัยจากอิทธิพลพายุโซนร้อนปาบึก พ.ศ. 2562 ในจังหวัดนครศรีธรรมราช
Authors: ปาละคะมาน ธวัฒชัย
Published: October 2023

การวิจัยในครั้งนี้มีวัตถุประสงค์เพื่อ 1) ทบทวนบริบทและแนวคิดระบบเตือนภัยล่วงหน้าสำหรับอุทกภัยที่มีในประเทศไทยและต่างประเทศ 2) ศึกษาการบริหารจัดการของระบบเตือนภัยล่วงหน้าสำหรับอุทกภัยของประเทศไทยในเหตุการณ์อุทกภัยจากอิทธิพลพายุโซนร้อนปาบึกในพื้นที่จังหวัดนครศรีธรรมราช  3) ข้อเสนอแนะเชิงนโยบายต่อการเสริมสมรรถนะกลไกเชิงสถาบันของระบบเตือนภัยล่วงหน้าสำหรับอุทกภัยของประเทศไทยในพื้นที่จังหวัดนครศรีธรรมราช โดยใช้วิธีการวิจัยแบบผสมผสาน ซึ่งมีการใช้เครื่องมือการวิเคราะห์เครือข่ายทางสังคมและการสัมภาษณ์เชิงลึก วิธีเชิงปริมาณโดยใช้แบบสอบถาม ผลจากการวิเคราะห์ข้อมูล พบว่า 1) ประเทศไทยมีหน่วยงานที่มีอำนาจหน้าที่ตามกฎหมายเพื่อดำเนินการด้านการเตือนภัยจำนวนมาก แต่มีการดำเนินการเตือนภัยที่สอดคล้องกับมาตรฐานสากลโดยเฉพาะในหน่วยงานระดับส่วนกลาง 2) ภาพรวมของเครือข่ายการเตือนภัยล่วงหน้าอยู่ในลักษณะการผสมผสานระหว่างเครือข่ายตารางแบบบางส่วนกับเครือข่ายที่เข้าถึงได้หลายช่องทางที่ไม่สมบูรณ์ บ่งชี้ว่า 2.1) เครือข่ายขาดการกำหนดบทบาทหน้าที่และทิศทางอย่างเป็นทางการจึงทำให้สมาชิกในเครือข่ายมีปฏิสัมพันธ์กันในระดับต่ำ 2.2) สมาชิกในเครือข่ายไม่มีการดำเนินกิจกรรมด้านการเตือนภัยล่วงหน้าเป็นการเฉพาะพอที่จะก่อให้เกิดการปฏิสัมพันธ์ระหว่างกัน ส่งผลให้เครือข่ายขาดความเหนียวแน่น และ 2.3) เครือข่ายในระดับท้องถิ่นขาดการเชื่อมโยงกับกลไกการเตือนภัยล่วงหน้าอย่างเป็นระบบ 3) เสนอให้มีการกำหนดให้มียุทธศาสตร์การเตือนภัยล่วงหน้าเป็นการเฉพาะที่กำหนดความสัมพันธ์เชิงอำนาจอย่างเป็นทางการของหน่วยงานต่าง ๆ ให้สอดคล้องกัน ตลอดจนกำหนดกลไกการติดตาม การประเมินผล และการพิจารณางบประมาณด้านการเตือนภัยที่มีเอกภาพทั้งประเทศ ตลอดจนกำหนดกลไกและการเตรียมพร้อมด้านการเตือนภัยในระดับพื้นที่อย่างเป็นรูปธรรมในแผนการจัดการภัยพิบัติท้องถิ่น และจัดให้มือคู่มือมาตรฐานปฏิบัติการด้านการเตือนภัย
การเมืองของชนชั้นนำในเวียดนามกับสิ่งท้าทายใหม่ในโลกปั่นป่วน
Authors: กาญจนขุนดี สุภลักษณ์ , ประทีปวัฒนะวงศ์ มุกดา
Published: October 2023

การเมืองของชนชั้นนำเวียดนามคือ การเมืองในพรรคคอมมิวนิสต์เวียดนามที่อาศัยความชอบธรรม 2 ชนิดที่ค้ำจุนให้อยู่ในอำนาจนับแต่ได้เอกราชในปี 1945 คือ ประการแรก ความชอบธรรมทางอุดมการณ์ที่อ้างอิงจากการต่อสู้เพื่อปลดปล่อยประเทศจากการเป็นอาณานิคมฝรั่งเศสและเปลี่ยนแบบแผนทางการเมืองให้เป็นแบบอำนาจนิยมรวมศูนย์อยู่ที่พรรคคอมมิวนิสต์เท่านั้น และมีแบบแผนทางเศรษฐกิจเป็นแบบสังคมนิยม ประการที่สอง ความชอบธรรมทางด้านผลงานจากความสำเร็จทางเศรษฐกิจหลังการปฏิรูปโด่ยเหมยในปี 1986 ซึ่งได้เปลี่ยนแปลงเศรษฐกิจจากแบบวางแผนเป็นเศรษฐกิจสังคมนิยมแบบตลาด เปิดโอกาสให้ประชาชนเวียดนามได้สะสมความมั่งคั่งขึ้นมาได้อย่างมาก บทความนี้ใช้แนวคิดของ Samuel Huntington ที่ว่าความสำเร็จในการพัฒนาเศรษฐกิจจะนำไปสู่ความเป็นประชาธิปไตยเพราะกลุ่มคนที่มั่งคั่งมักจะเป็นกลุ่มกดดันทางการเมืองเรียกร้องการเปลี่ยนแปลงเพื่อให้รัฐตอบสนองความต้องการและทำให้การสะสมความมั่งคั่งทำให้ราบรื่นมากขึ้น แต่ได้โต้แย้งว่า แม้ความสำเร็จทางเศรษฐกิจจะก่อให้เกิดชนชั้นใหม่ในเวียดนาม แต่กลุ่มพลังทางสังคมกลุ่มนี้ไม่ได้แสดงความเป็นปรปักษ์หรือท้าทายต่ออำนาจนำทางการเมืองของพรรคคอมมิวนิสต์แต่อย่างใด เพราะเหตุที่พวกเขาล้วนอาศัย โครงสร้างอำนาจ นโยบาย และเส้นสายในกลไกรัฐและพรรคคอมมิวนิสต์ในการสร้างฐานะขึ้นมา กล่าวในอีกแง่หนึ่งการรวมศูนย์อำนาจของพรรคคอมมิวนิสต์ไม่ได้เป็นอุปสรรคต่อการดำเนินธุรกิจและการสะสมความมั่งคั่งของชนชั้นใหม่นี้แต่อย่างใด ในอีกทางหนึ่งความสำเร็จทางธุรกิจของชนชั้นใหม่นี้มีส่วนอย่างมากในการเกื้อหนุนความชอบธรรมในเชิงผลงานแก่พรรคคอมมิวนิสต์ทำให้มีแรงสนับสนุนให้อยู่ในอำนาจได้ต่อไป สิ่งที่ท้าทายอำนาจของพรรคคอมมิวนิสต์เวียดนามยุคปัจจุบัน คือกลุ่มคนที่ถูกละเลยหรือพลาดโอกาสในการใช้โครงสร้างทางอำนาจของพรรคและรัฐเพื่อสนองความต้องการของตนเองหรือกล่าวอีกนัยหนึ่งคือ นอกจากจะไม่ได้รับผลประโยชน์ใด ๆ จากการพัฒนาหากแต่ยังอาจจะได้รับผลกระทบให้เกิดความเสียหายอีกด้วย กลุ่มคนเหล่านี้ได้อาศัยสื่อสังคมออนไลน์เป็นเครื่องมือในการแสดงออกและเรียกร้องสิทธิของตนเอง ซึ่งทำให้พรรคคอมมิวนิสต์ต้องหาทางตอบโต้ จำกัด และกำจัดในที่สุด บทความนี้พัฒนาจาก“โครงการชนชั้นนำและแรงงานในเอเชียตะวันออกเฉียงใต้:องค์ประกอบ โครงสร้างและพลวัตในยุคเปลี่ยนผ่าน” ซึ่งศึกษาและสำรวจการเมืองชนชั้นนำของเวียดนามจากเอกสารของภาครัฐ รายงานขององค์กรเอกชน หนังสือ วารสารและรายงานของสื่อมวลชนเป็นหลัก
PERBAIKAN TATA LETAK GUDANG BARANG JADI UNTUK MEMINIMALISIR BIAYA PERPINDAHAN BARANG DENGAN METODE DEDIKATED STORAGE DI PT. CIPTA NISSIN INDUSTRIES
Authors: Putra Andika
Published: October 2023

. PT. Cipta Nissin Industries adalah perusahaan manufaktur yang mengkhususkan diri dalam pembuatan Knalpot Sistem & komponen-komponen. Permasalahan yang dihadapi dipabrik ini adalah penyusunan barang jadi digudang masih belum teratur atau masih belum tertata rapi, sehingga bisa menyebabkan bertumpuknya barang pada gudang barang jadi serta tidak ada nya aliran barang yang mempermudah material handling untuk menyimpan dan mengirim barang sesuai dengan waktu yang ditentukan. Untuk itu perlu dilakukan penataan lokasi penyimpanan produk pada gudang barang jadi dengan menggunakan metode dedicated storage agar barang memiliki tempat penyimpanan yang tetap (fixed), agar mempermudah para pekerja dalam penyimpanan maupun pengiriman barang. Hasil dari perbaikan dengan metode dedicated storage didapatkan perbaikan jarak yang sebelumnya 259,99 m menjadi 230,1 m dan total jarak keseluruhan sebelum perbaikan 20.633,41 m dan setelah perbaikan menjadi 4.962,4 m dan material handling cost sebelum perbaikan sebesar Rp. 110.319.014 dan sesudah perbaikan sebesar Rp. 51.332.211.
PERANCANGAN TATA LETAK MATERIAL DI GUDANG BAHAN BAKU MENGGUNAKAN METODE CLASS BASED STORAGE DI PT KMI WIRE AND CABLE
Authors: Aloan Firman
Published: October 2023

Kondisi pada penyimpanan dan penyusunan material yang dilakukan secara acak dankurang teratur akan mengakibatkan terjadinya proses pencarian dan pengambilan material yanglama, hal ini menyebabkan pengiriman ke departemen produksi terlambat. Penelitian ini akanmembahas usulan tata letak Gudang untuk mengurangi waktu tunda pencarian denganmenggunakan metode class based storage. Penelitian dilakukan dengan meneliti 10 item produkdengan tujuan untuk mengetahui tata letak barang di gudang bahan material berdasarkanklasifikasi ABC. Penelitian dilakukan dengan mencari penyebab penempatan dan penyusunanbarang yang tidak teratur, kemudian melakukan tata letak barang digudang bahan material.Penelitian menunjukan bahwa dari 10 item produk tersebut didapatkan hasil pengelompokanmenjadi tiga kelas yaitu : 1) kelas A : jumlah persediaan 75,1% dengan jumlah item sebanyak 3item, 2) kelas B : jumlah persediaan 15,6% dengan jumlah item sebanyak 3 item, dan 3) kelas C :jumlah persediaan 9,3% dengan jumlah item 4. Perhitungan material handling cost sebelumperbaikan sebesar Rp 7.670.268 per shift dan sesudah perbaikan sebesar Rp 3.511.618 per shift,menghasilkan efisiensi sebesar Rp 4.158.650.
Legendary Career and Colorful Life: A Conversation with Dr. Bob Riffenburgh
Authors: Bar Haim , Yan Jun
Published: October 2023

In 2022 the American Statistical Association established the Riffenburgh Award, which recognizes exceptional innovation in extending statistical methods across diverse fields. Simultaneously, the Department of Statistics at the University of Connecticut proudly commemorated six decades of excellence, having evolved into a preeminent hub for academic, industrial, and governmental statistical grooming. To honor this legacy, a captivating virtual dialogue was conducted with the department’s visionary founder, Dr. Robert H. Riffenburgh, delving into his extraordinary career trajectory, profound insights into the statistical vocation, and heartfelt accounts from the faculty and students he personally nurtured. This multifaceted narrative documents the conversation with more detailed background information on each topic covered by the interview than what is presented in the video recording on YouTube.
Vesterbjerg
Authors: Knudsen Thomas Rune , Kveiborg Jacob
Published: October 2023

Udgravningen ved Vesterbjerg i Brovst afslørede en bebyggelse der dækkede 1,5 ha og inkluderede 44 bygninger, primært dateret til tidlig middelalder. Bemærkelsesværdige fund inkluderer to store enkeltskibede langhuse, hvor alle gårdens funktioner sandsynligvis har været under ét tag samt små vinkelformede toskibede bygninger. Den dominerende hustype syntes at være det enkeltskibede hus med rektangulær grundplan, selvom der var betydelig variation i husenes dimensioner, konstruktion og orientering. Udgravningen resulterede i en stor mængde dyreknogler, primært fra domesticerede arter. En hund var blevet gravlagt, mens en hoppe var blevet nedkulet i et hul efter en mislykket foling. En gennemgang af knoglematerialet antyder, at nogle af landsbyens dyr måske er blevet sendt til nærliggende markeder, hvorimod fx udtjente heste, til trods for kristendommens forbud mod spisning af hestekød, alligevel kunne ende på spisebordet.
Women entrepreneurs in a Botswana context: drivers for success
Authors:   , Khupe Duduzile Beryl
Published: October 2023

In this study, an exploration of how successful women entrepreneurs in Botswana navigate the entrepreneurship experience was undertaken, as it often involves barriers and challenges that stifle women entrepreneurs participating successfully in the economic environment. The onset of the Covid-19 pandemic aggravated the conditions even further for women entrepreneurs. A qualitative framework was adopted for the research, grounded in Theory of Motivation and the mindset of the Anti-Fragility Theory. An interview method was employed for the study, underpinned by phenomenology and social constructionism, with a sample of fifteen women entrepreneurs based in Botswana and South Africa. NVivo Software was used for coding and data analysis. The enablers, including resilience and agility, which contribute to the success of women entrepreneurs, while they navigate the complex world in which they operate, were also interrogated in the study. A literature review of women entrepreneurship was undertaken, and theories of entrepreneurship were revisited. The causal link between women entrepreneurship, the growth mindset, agility and economic growth was investigated as well as the means to identify the removal of challenges and barriers to entry, concluding with recommendations based on the outcome and findings of the field research. The main findings of the research were that successful women adopt an entrepreneurial mindset associated with a positive mindset and use agility/anti-fragility to survive adverse economic conditions. In addition, access to finance remains the biggest challenge that women entrepreneurs face in Botswana. Spirituality and religion were also found to be a motivating factor to establish a business venture. Entrepreneurial spirituality is drawing increasing attention from researchers of entrepreneurship. The key pitfall that women entrepreneurs encounter remains access to capital, although in different forms for the two countries used in the study.
Niagara County, New York
Authors: Aikin Bruce D.
Published: October 2023

This article addresses several topics related to Niagara County, New York: the steamboat Caroline and its destruction and how Americans responded; the secret Hunter’s Lodges and, more specifically, their support for the notorious rebel, Benjamin Lett; incidents connected to Navy Island; William Lyon Mackenzie’s son James; Alexander McLeod’s trial; and the legacy of the Patriot War.
The Patriot Press and their Paper Tiger
Authors: Smith Stephen R. I.
Published: October 2023

While a major focus in studies of the Rebellion has been the secret society the Patriot Hunters, one understudied aspect to the Rebellion is the continued role of allied newspapers in organizing rebellion in the Canadas and subsequently sustaining it in exile. The article provides an overview of the “patriot press” and how it helped delineate the patriot movement in exile. In the press, terms and language associated with the Patriot Hunters provided a tool to unite patriots. While some patriot editors expressed aversion to secrecy, some of those same editors now used references to secret organizing as ploys to reassure readers that they were part of a larger, highly active, and highly successful organization committed to Canadian independence—even if that was not true.
The Many Lives of James Milne Aitchison, Battle of Windsor Raider
Authors: Hundey Ian
Published: October 2023

James Milne Aitchison was a privileged child in rural Scotland, a troubled young man in Edinburgh, a failed immigrant in Upper Canada, a Patriot raider at the Battle of Windsor in December 1838, a Van Diemen’s Land (Tasmania) convict, and a colonist in what is now Victoria State, Australia. This article explores Aitchison’s many ‘lives’, drawing on fifty years of the author’s research-findings including material from the recent rescue of a cache of Aitchison documents from an abandoned house in Scotland.
The Long Odyssey of Chauncey Sheldon, a Survivor of the 1838 Patriot War
Authors: Carter John C.
Published: October 2023

Between December 1837 and December 1838, there were at least 14 recorded armed and unsanctioned incursions from United States into Upper Canada undertaken by what was referred to as the “Patriot Army.” Its intention was to overthrow what was seen by some as “oppression” and “British tyranny.” While none of these raids were successful, over 1,000 men involved with these raids were arrested, many of whome were charged with piratical invasion/high treason. One of those men was Chauncey Sheldon. This is his story.
The experience of computerized content analysis of articles of the journal "Bulletin of Finance, Industry and Trade" for 1917
Authors: Voronkova Daria Sergeevna
Published: October 2023

The subject of the research is the materials of articles of the journal "Bulletin of Finance, Industry and Trade" for 1917 – the leading printing body of the Ministry of Finance. The methodological basis of the article was a computerized content analysis, which made it possible to fully reveal the information potential of the source. Special attention is paid to the construction of a representative system of semantic categories and indicators based on the frequency dictionary, which revealed thematic priorities and semantic accents in the entire array of issues of the "Bulletin ..." in the specified year. The analysis of the frequency of occurrence of the created categories (including joint ones) in dynamics by quarters is carried out. The interrelationships of the categories make possible conclusions based on the argumentation of the authors of the journal articles.   The materials of Vestnik ... have previously attracted the attention of scientists, but only now, with the help of computerized content analysis, a hidden layer of information contained in it has been introduced into scientific circulation, which is the scientific novelty of the work. The content analysis showed that the journal "Bulletin of Finance, Industry and Trade" reflected the situation and processes in the socio-political sphere in the country and abroad that developed in the economy at the turning point of 1917, unfolding against the background of the ongoing First World War. The main core of the constructed system of semantic categories turned out to be financial issues in close connection with the industrial, trade and tax spheres, as well as problems caused by the war and growing in the economy and society.
Digital archaeology today: achievements and challenges
Authors: Korobov Dmitry Sergeevich
Published: October 2023

Over the last decade, the active use of various computer methods and digital technologies has had a profound impact on modern archaeological research. New methods of field recording have emerged, and modern tools such as laser total stations and scanners, GNSS receivers and unmanned aerial vehicles have become firmly embedded in archaeological practice. A whole trend of the Digital Archaeology has emerged within the framework of which many archaeologists are working. It seems relevant to summarize some of the results of the development of digital archaeology over the past decades and to highlight the main trends in the modern use of a number of technological techniques that have significantly affected the image of archaeological research at this stage. The article highlights the main methods and approaches in digital recording, analysis and visualization of archaeological information: geographic information systems, digital archives and databases, field electronic diaries, photogrammetry and laser scanning methods of different spatial levels, as well as the first steps in the use of artificial intelligence in archaeological practice. Such an overview, although limited, covers for the first time all the major trends in digital archaeology of the last two decades. In addition to the achievements that are certainly present in the works cited, the author pays special attention to some of the challenges that arise in the process of implementing digital archaeology in everyday archaeological practice.
The ratio of wages of workers and employees in the censorship industry of the Siberian Region in the second half of the 1920s.
Authors: Vladimirov Vladimir Nikolayevich
Published: October 2023

The article examines the issues of remuneration of employees of the enterprises of the censorship industry of Siberia during the years of the NEP and the ratio of salaries of different categories of employees to workers' salaries, which allows us to identify the degree of income inequality between them, as well as to answer the question of how great was the differentiation of their financial situation, and not only in general, but also by individual industries. No less important is the question of trends in the dynamics of indicators of this differentiation in the very short period of the NEP, when approaches to state regulation of this important social process were formed. It is shown that, in general, during the period under review, the ratio of salaries of workers and employees at the enterprises of the censorship industry of the Siberian Territory was stable and at the same time differed greatly depending on the industry and the position of the employee. It is concluded that these differences were smaller than at the very beginning of the XX century. Despite the general equalizing trend in wage policy and the corresponding activity of trade unions, the economic need for the material interest of employees forced to maintain a certain level of wage inequality, and in some employees even slightly increase it.
From the cadastral books to GIS: Toropets, Belaya, Rzheva borders in 15th – 17th centuries
Authors: Stepanova Iuliia , Karpova Mariya Vladimirovna
Published: October 2023

The article presents the results of studying the regions located on the western boundary of the Russian state of the XVI-XVII centuries. The object of the study is Toropetsky Uyezd and its eastern volosts - Dubna, Rozhna, Bibirevo and Startsova, which in the XV century formed the Moscow-Lithuanian border. Territorial transformations of these volosts in the XV-XVII centuries are considered. Based on written sources, the GIS localization of the border between Toropetsky, Belsky and Rzhevsky counties, the most important in the study of border situations during the XV-XVII centuries, was carried out. The main sources of the study are scribal descriptions of Toropetsky, Belsky, Rzhevsky counties of the XVI-XVII centuries, including previously unpublished and introduced into scientific circulation. The study was conducted using geoinformation technologies. The use of geoinformation technologies in the work on the continuous localization of toponyms of scribal descriptions of three counties allowed us to get a more detailed idea of the territory of the Toropetsky district before its entry into the Russian State. Startsova Parish stretched south from Toropets to the large Peletsky Moss swamp. Its southeastern part, lying on the left bank of the Western Dvina, was assigned to Belaya even before Toropets and Belaya joined Moscow. Rozhnya and Bibirevo in the 1520s and 1530s also went to Moscow. Finally, Dubna changed its size and status as a result of the border conflicts of the XV century and land policy in Russia of the XVI-XVII centuries. The location of the Zhukopsky pit marking the road crossing the Moscow-Lithuanian border has been established.
Neuromodulation of striatal D1 cells shapes BOLD fluctuations in anatomically connected thalamic and cortical regions
Authors: Markicevic Marija , Sturman Oliver , Bohacek Johannes , Rudin Markus , Zerbi Valerio , Fulcher Ben D , Wenderoth Nicole
Published: October 2023

Understanding how the brain’s macroscale dynamics are shaped by underlying microscale mechanisms is a key problem in neuroscience. In animal models, we can now investigate this relationship in unprecedented detail by directly manipulating cellular-level properties while measuring the whole-brain response using resting-state fMRI. Here, we focused on understanding how blood-oxygen-level-dependent (BOLD) dynamics, measured within a structurally well-defined striato-thalamo-cortical circuit in mice, are shaped by chemogenetically exciting or inhibiting D1 medium spiny neurons (MSNs) of the right dorsomedial caudate putamen (CPdm). We characterize changes in both the BOLD dynamics of individual cortical and subcortical brain areas, and patterns of inter-regional coupling (functional connectivity) between pairs of areas. Using a classification approach based on a large and diverse set of time-series properties, we found that CPdm neuromodulation alters BOLD dynamics within thalamic subregions that project back to dorsomedial striatum. In the cortex, changes in local dynamics were strongest in unimodal regions (which process information from a single sensory modality) and weakened along a hierarchical gradient towards transmodal regions. In contrast, a decrease in functional connectivity was observed only for cortico-striatal connections after D1 excitation. Our results show that targeted cellular-level manipulations affect local BOLD dynamics at the macroscale, such as by making BOLD dynamics more predictable over time by increasing its self-correlation structure. This contributes to ongoing attempts to understand the influence of structure–function relationships in shaping inter-regional communication at subcortical and cortical levels.
Repurposing the mammalian RNA-binding protein Musashi-1 as an allosteric translation repressor in bacteria
Authors: Dolcemascolo Roswitha , Heras-Hernández María , Goiriz Lucas , Montagud-Martínez Roser , Requena-Menéndez Alejandro , Ruiz Raúl , Pérez-Ràfols Anna , Higuera-Rodríguez R Anahí , Pérez-Ropero Guillermo , Vranken Wim F , Martelli Tommaso , Kaiser Wolfgang , Buijs Jos , Rodrigo Guillermo
Published: October 2023

The RNA recognition motif (RRM) is the most common RNA-binding protein domain identified in nature. However, RRM-containing proteins are only prevalent in eukaryotic phyla, in which they play central regulatory roles. Here, we engineered an orthogonal post-transcriptional control system of gene expression in the bacterium Escherichia coli with the mammalian RNA-binding protein Musashi-1, which is a stem cell marker with neurodevelopmental role that contains two canonical RRMs. In the circuit, Musashi-1 is regulated transcriptionally and works as an allosteric translation repressor thanks to a specific interaction with the N-terminal coding region of a messenger RNA and its structural plasticity to respond to fatty acids. We fully characterized the genetic system at the population and single-cell levels showing a significant fold change in reporter expression, and the underlying molecular mechanism by assessing the in vitro binding kinetics and in vivo functionality of a series of RNA mutants. The dynamic response of the system was well recapitulated by a bottom-up mathematical model. Moreover, we applied the post-transcriptional mechanism engineered with Musashi-1 to specifically regulate a gene within an operon, implement combinatorial regulation, and reduce protein expression noise. This work illustrates how RRM-based regulation can be adapted to simple organisms, thereby adding a new regulatory layer in prokaryotes for translation control.
Piezo1 mechanosensing regulates integrin-dependent chemotactic migration in human T cells
Authors: Liu Chinky Shiu Chen , Mandal Tithi , Biswas Parijat , Hoque Md Asmaul , Bandopadhyay Purbita , Sinha Bishnu Prasad , Sarif Jafar , D'Rozario Ranit , Sinha Deepak Kumar , Sinha Bidisha , Ganguly Dipyaman
Published: October 2023

T cells are crucial for efficient antigen-specific immune responses and thus their migration within the body, to inflamed tissues from circulating blood or to secondary lymphoid organs, plays a very critical role. T cell extravasation in inflamed tissues depends on chemotactic cues and interaction between endothelial adhesion molecules and cellular integrins. A migrating T cell is expected to sense diverse external and membrane-intrinsic mechano-physical cues, but molecular mechanisms of such mechanosensing in cell migration are not established. We explored if the professional mechanosensor Piezo1 plays any role during integrin-dependent chemotaxis of human T cells. We found that deficiency of Piezo1 in human T cells interfered with integrin-dependent cellular motility on ICAM-1-coated surface. Piezo1 recruitment at the leading edge of moving T cells is dependent on and follows focal adhesion formation at the leading edge and local increase in membrane tension upon chemokine receptor activation. Piezo1 recruitment and activation, followed by calcium influx and calpain activation, in turn, are crucial for the integrin LFA1 (CD11a/CD18) recruitment at the leading edge of the chemotactic human T cells. Thus, we find that Piezo1 activation in response to local mechanical cues constitutes a membrane-intrinsic component of the ‘outside-in’ signaling in human T cells, migrating in response to chemokines, that mediates integrin recruitment to the leading edge.
Cuproptosis-related lncRNA SNHG16 as a biomarker for the diagnosis and prognosis of head and neck squamous cell carcinoma
Authors: Han Baoai , Li Shuang , Huang Shuo , Huang Jing , Wu Tingting , Chen Xiong
Published: October 2023

Background

We aim to investigate the potential value of cuproptosis-related lncRNA signaling in predicting clinical prognosis and immunotherapy and its relationship with drug sensitivity in head and neck squamous cell carcinoma (HNSCC).

Methods

We first identified the lncRNAs associated with cuproptosis genes in HNSCC and then conducted a series of analytical studies to investigate the expression and prognostic significance of these lncRNAs. Finally, we used RT-qPCR to validate our findings in a laryngeal squamous cell carcinoma cell line and 12 pairs of laryngeal squamous cell carcinoma and adjacent normal tissues.

Results

We identified 11 differentially expressed lncRNAs that were associated with cuproptosis genes in HNSCC and also served as prognostic markers for this cancer. Enrichment analysis revealed that these lncRNAs were related to immune-related functions that were suppressed in patients with oncogene mutations in the high-risk group. The patients with a high tumor mutation burden exhibited poor overall survival (OS). We used the tumor immune dysfunction and exclusion model to show that the patients in the high-risk group had great potential for immune evasion and less effective immunotherapy. We also identified several drugs that could be effective in treating HNSCC. Experimental validation showed that AC090587.1 and AC012184.3 exhibited differential expression between the TU686 and HBE cell lines, and SNHG16 showed differential expression among the TU686, TU212, and control HBE cells. Among the 12 pairs of cancer and adjacent tissues collected in the clinic, only SNHG16 showed differential expression. Targeted therapy against SNHG16 holds promise as a prospective novel strategy for the clinical management of HNSCC.
An application of topological data analysis in predicting sumoylation sites
Authors: Lin Xiaoxi , Gao Yaru , Lei Fengchun
Published: October 2023

Sumoylation is a reversible post-translational modification that regulates certain significant biochemical functions in proteins. The protein alterations caused by sumoylation are associated with the incidence of some human diseases. Therefore, identifying the sites of sumoylation in proteins may provide a direction for mechanistic research and drug development. Here, we propose a new computational approach for identifying sumoylation sites using an encoding method based on topological data analysis. The features of our model captured the key physical and biological properties of proteins at multiple scales. In a 10-fold cross validation, the outcomes of our model showed 96.45% of sensitivity (Sn), 94.65% of accuracy (Acc), 0.8946 of Matthew’s correlation coefficient (MCC), and 0.99 of area under curve (AUC). The proposed predictor with only topological features achieves the best MCC and AUC in comparison to the other released methods. Our results suggest that topological information is an additional parameter that can assist in the prediction of sumoylation sites and provide a novel perspective for further research in protein sumoylation.
Multicriteria decision support method CRITIC-WASPAS-N in the analysis of transportation companies on the stock exchange in the brazilian market
Authors: Dos Santos Raphael Nascimento , Da Silva Paulo Afonso Lopes
Published: October 2023

The aim of this article is to identify how multi-criteria decision support (MCDA) can help investment portfolios in transportation and logistics companies on the stock exchange. To develop this article, a stratification was carried out within BM&FBOVESPA with logistics and transportation companies presented on the Brazilian Stock Exchange. 16 transportation companies in the fundamentus data source. The data was collected from 5 financial indicators, selected according to the Principal Component Analysis (PCA) carried out by Basilio et al. (2018). The CRITIC method was used to generate the weights and normalize the decision matrix and the WASPAS method is used to classify assets. At the end of this stage, it was possible to classify the best alternatives for investing in transportation. After constructing portfolios, it was possible to see which company was most suitable for positive returns on investment. The result is a safe company to invest in logistics and transportation infrastructure in the Brazilian stock market through MCDA analysis and a sensitivity analysis. Research limitations/implications - Since the study is focused only on logistics and transportation companies, the study limited the alternatives with only 15 companies.  An investor in transportation infrastructure economics can apply the conclusions of this article to other segments of the stock market. This study presents a methodology by merging the CRITIC method for generating weights and normalization and WASPAS with the normalization of the CRITIC method to build efficient investment portfolios.
MANAGEMENT IN A DYNAMICALLY CHANGING REALITY: CONSEQUENCE VERSUS NON-CONSEQUENCE
Authors: OSBERT-POCIECHA Grażyna
Published: October 2023

This article analyses the importance of consequence and non-consequence as conditions for effective management. In conditions of continuous and imminent change taking place both within companies and in their environment (described by the VUCA and BANI models), the role of consequence in management, understood as achieving one’s goal(s), is also changing. Given the tendency towards the atrophy of consequence, increasing chaos, and the appearance of various types of paradox, there is a need to “be non-consequential”, in particular in the strategic dimension of management. The results of a survey on Polish managers’ perceptions of consequence and non-consequence are used to exemplify the theoretical considerations. The results indicate a “deep-rooted” tendency to maintain consequence within the traditional approach to management. This points to a need to increase the openness of Polish managers to non-consequence, which is desirable in the conditions of a dynamically changing reality.
Wood Fibre Properties and Genetic Divergence in Haldina cordifolia (Roxb.) Ridsdale
Authors: Warrier Kannan C. S. , Abinaya R. , Gireesan K. , Jayakumar M.
Published: October 2023

Haldina cordifolia is a multipurpose tree species. It is one of the best Indian timbers suitable for flooring, panelling and for railway carriages. It is also suitable for pulp and paper, construction, window frames, furniture, bobbins, piano keys and rulers. Wood is also used for pencil manufacturing. Though many phyto-chemicals and pharmacological compounds have been identified from this tree species, the species has not been domesticated so far. ICFRE-Institute of Forest Genetics and Tree Breeding, Coimbatore has initiated a tree improvement programme in this tree species since 2018 and plus trees numbering 141 have been selected from the state of Kerala. Eucalyptus spp., Casuarina spp., and Poplars are the major sources of wood pulp used by the paper industries in India. Efforts are being undertaken by various research institutions in India to find alternate indigenous tree species suitable for pulp. Therefore, a study was undertaken to understand the wood fibre properties of select Plus Trees of H. cordifolia. Wood samples collected from 30 select plus trees have been subjected to wood fibre analyses and genetic divergence studies. Wood specific gravity varied from 0.62 to 0.71. Various wood fibre ratios were also studied. Among the 30 Plus Trees studied, HC 01, HC 03, HC 04, HC 05, HC 18, HC 26 and HC 27 have registered ideal values for using them for paper making. The maximum value for broad sense heritability was recorded by Felting coefficient (0.75). Coefficient of fibre flexibility, Isenberg coefficient, Runkel’s ratio and Lumen diameter also registered reasonably higher values for H2. Application of Mahalanobis’ D2 statistics and Tocher’s clustering method resolved 30 Plus Trees into 6 clusters. The cluster strength varied from one in cluster 6 to 21 in cluster 1. The remaining 4 clusters contained two trees each. Genetic divergence studies have shown that Plus Trees namely, HC 22, HC 23, HC24, HC 27, HC 28, HC 29 and HC 30 could be utilized for further tree breeding programmes.
Perspective Analysis of the Physical and Engineering Properties of Coriander Seed at Different Moisture Contents
Authors: Pal Ramesh , Kumar Ram , Tripathi Ashok , Chaudhary Sachin , Satyartham  , Singh Virendra
Published: October 2023

Coriander (Coriandrum sativum L.) is an important leafy vegetable of family Umbelliferae with small fruits of great medicinal and nutritional value used as spice and condiment. As a marginal spice crop it is cultivated worldwide since centuries but its genetic diversity has rarely been documented. Threshing is one of the major problems associated with coriander production in India. In spite of the food and nutritional importance of the crop to human diet, its threshing has been and remains a serious problem to the farmers. The techniques for threshing coriander in most rural areas are still the traditional methods of seed separation which are uneconomical, labourous and time consuming. Under the present investigation coriander crop was selected for study. Physical, aerodynamic and frictional properties of above seeds were determined in order to decide parameters for the purpose of designing and performance evaluation of a thresher to threshing coriander.
Peripapillar Radial Nerve Fiber Layer (RNFL) and Choroidal Macular Thickness (CMT): Valid Biomarkers of Disability Progression during One Year in Patients with Multiple Sclerosis (MS)
Authors: Cerdà-Ibáñez Marta , Domínguez Laura Manfreda , Duch-Samper Antonio
Published: October 2023

Aims: Multiple Sclerosis (MS) is an inflammatory disease that shows a great variability in its clinical aspects. This study investigate whether vascular changes (choroidal thickness and macular vascular plexuses) as well as changes in the thickness of retinal nerve fiber layers and retinal ganglion cells occur over one year in patients with MS and if these changes are related with the disability that the patients have.
Study Design:  Prospective observational study.
Place and Duration of Study: Department of Ophthalmology and Neurology (in Hospital Clínico Universitario de Valencia (Spain). Between January 2016 and September 2017.
Methodology: It was analysed 104 eyes of MS patients (divided in groups depending of the type of the MS and their grade of disability measured by the Expanded Disability Status Scale (EDSS) by Kurtzke). Anatomical parameters: RNFL and ganglion cell layer (GCL) were studied using optical coherence tomography (OCT). Vascular parameters were analysed: CMT by OCT and the macular vascular plexuses by OCT-angiography (OCTA). Any subject has an optical neuritis history or other comorbidities.
Results: RFNL was thinner in the highest degree of disability group and in patients with primary progressive MS (PPMS). CMT showed a significant decreased in the group that has moderate-severe disability and showed a decrease in the group that their disability worsened during the year of study. Retinal macular plexus showed no difference in any group at one year of study Conclusion: The study of the RFNL and CMT are objective and valuable indicators in these patients, especially with regard to the progression of their disability and with the worst forms of the disease.
Did COVID-19 Trigger a Digital Epidemic? An Exploratory Study in Adolescents
Authors: Puri Sonia , Sharma Muneesh , Jain Rajat , Vishnu Narayanan S.  , Malhotra Nitya , Duggal Mona , Das Subash , Singh Amarjeet
Published: October 2023

Background: This study aims to investigate the usage pattern of gadgets during the COVID-19 pandemic and its potential long-term consequences.

Materials & Methods: Observational cross-sectional study. This design is helpful for public health planning, monitoring, and evaluation of demographically diverse populations of varied age groups, socioeconomic status, religion, etc. The research gathered information on participants' demographic characteristics, gadget usage patterns, and reasons behind the increased reliance on gadgets. Additionally, questions were asked to gain deeper insights into participants' subjective experiences and perceptions regarding gadget usage during the pandemic. Multi-stage random sampling was done. One thousand one hundred fifty-five students were recruited from diverse geographic locations and demographic backgrounds. The study instrument used was a pretested, validated questionnaire. Field investigators collected the data after taking informed consent from participants. Data were compiled and analysed using SPSS 23.

Results: A substantial increase in gadget usage during the COVID-19 pandemic was found in this study. Participants reported heightened dependency on gadgets for remote learning, virtual social interactions, recreation or seeking information, etc. Factors such as social isolation, restrictions on physical activities, and the need for constant connectivity contributed to the surge in gadget usage. However, excessive screen time and digital fatigue were noted as negative consequences of this increased reliance.

Conclusions: The study highlights the unprecedented rise in gadget usage during the COVID-19 pandemic and its multifaceted implications. While gadgets have played a crucial role in facilitating remote work and maintaining social connections, excessive reliance on them challenges to individuals' well-being. It is crucial to develop strategies to address the potential negative consequences, such as promoting digital well-being and finding a balance between virtual and offline activities. Further research is warranted to examine the long-term effects of increased gadget usage on mental health, social interactions, and overall quality of life.
From Pain Relief to Cancer Defense: The Promise of NSAIDs
Authors: Senthilnathan V.  , Priyadharshini V.  , Jenifer Selin Asha J.
Published: October 2023

NSAIDs (Non-Steroidal Anti-inflammatory Drugs) are commonly used to treat various types of pain and inflammation. In recent decades, extensive scientific research has been conducted to examine the use of NSAIDs in the treatment and prevention of cancer. Chronic inflammation has been linked to various cancer types, suggesting that prolonged inflammation can promote genetic mutations and accelerate their accumulation within cells. The COX pathway, short for Cyclooxygenase pathway, is a critical biochemical pathway in the human body involved in the production of important signaling molecules called prostaglandins. Key factors like COX enzymes and cytokines are important in the development and progression of inflammation-induced cancer. Angiogenesis occurs during inflammation, and it plays a major role in cancer development and metastasis. NSAIDs inhibit this process, which may also contribute to their anticancer effects. This review highlights the potential of NSAIDs, particularly aspirin, ibuprofen, and celecoxib, to influence various aspects of tumor behavior. Although promising, further rigorous studies are needed to establish their clinical efficacy and safety in diverse cancer scenarios. The use of NSAIDs as adjunctive therapies along with conventional treatments presents a promising avenue for enhancing cancer management strategies.
Phylogenetic Analysis to Detect COVID Superspreaders
Authors: Jungck John R. , Ko Hajae
Published: October 2023

Aims: Detection of superspreading events by phylogenetic analysis of nucleotide sequences from a population of individuals collected from a narrow time interval.

Study Design: Retrieve nucleic acid sequences, construct multiple sequence alignments, and build phylogenetic networks to determine sources of infection.

Place and Duration of Study: This study was performed at the Delaware Biotechnology Institute of the University of Delaware over the period: June-August, 2022. The data used were from the GIS AID database.

Methodology: Sequences for analysis were sampled from the GISAID initiative’s open-access SARS-CoV-2 genome database. We selected high-quality nucleotide sequences submitted by Delaware labs between March 18 and April 14, 2021, an important period of 4 weeks which saw the Alpha variant spread rapidly in the Delaware population.

Results: Four sources accounted for 215 of the 401 sequences. In other words, 54% of all cases were rooted in just five sources.

Conclusion: Thus, superspreading seems to have a major impact on the proportion of individuals in a population affected with COVID.
Blood Donation
Authors: Walter Kristin
Published: October 2023

This JAMA Patient Page describes the blood donation experience, why blood donation is important, and resources for people who want to donate blood.