bluuebunny/crossref_metadata_2025 huggingface dataset:
Gestión de desechos electrónicos en mercados emergentes
Authors: Ionescu Razvan
Published: September 2022

Un peligro ambiental grave, pero a menudo pasado por alto, son los desechos electrónicos. Estos se han considerado durante mucho tiempo un problema "exportable" y las naciones más ricas han enviado sus productos electrónicos al final de su vida útil a las partes más pobres del mundo durante décadas, ignorando los desastres ambientales creados y las innumerables vidas afectadas en vertederos masivos y sitios de procesamiento informal en Asia, África y América del Sur. Las economías emergentes como China, India y Brasil han representado durante mucho tiempo el destino final de los desechos electrónicos del mundo. Sin embargo, las cosas están comenzando a cambiar a medida que los peligros a corto y largo plazo de la eliminación inadecuada de desechos electrónicos comienzan a ser más evidentes. Este estudio se centra en los tres países mencionados y sus estrategias para combatir el problema de los desechos electrónicos. El propósito de este estudio es identificar las tendencias y los desafíos que enfrentan las economías emergentes cuando se enfrentan al creciente problema global de los desechos electrónicos, así como evaluar su respuesta tanto a nivel nacional como local.
Tácticas de marketing digital implementadas en las Mipymes del sector textil de Bogotá (Colombia) para captar clientes antes y durante la pandemia del COVID-19
Authors: Olaya Molano Juan Carlos , Mejía Henao Paula Andrea , Casanova Villareal Angela María
Published: September 2022

El artículo tiene como propósito aportar al incremento de la competitividad desde el área de marketing de las Mipymes del sector textil de Bogotá (Colombia). Teniendo en cuenta que las empresas y especialmente, las micro han sido afectadas en el desarrollo de sus actividades a través de la historia y particularmente con la aparición del COVID-19 en el entorno mundial. Sumado a lo anterior, se evidencia que las organizaciones no tienen un direccionamiento táctico en relación al marketing digital, lo que ha hecho que una gran proporción de Mipymes disminuyan sus ventas y, por ende, hayan desmejorado las garantías laborales y especialmente, el número de empleados para poder subsistir en el mercado. Como objetivo general se planteó identificar las tácticas de marketing digital implementadas en las Mipymes del sector textil de Bogotá (Colombia) para captar clientes antes y durante la pandemia del COVID -19. El marco teórico se fundamenta en la teoría de la mezcla de marketing digital expuesta por Chaffy y otros autores. Para la metodología se utilizó un análisis de corte mixto de tal forma que, en una primera instancia, se realizó la revisión de artículos incluidos en bases de datos, para fortalecer el marco referencia; en un segundo momento, se realizó la investigación de campo a través de la aplicación de una encuesta de corte longitudinal, para al final de la obtención de la información, realizar la comparación de los datos antes y durante la pandemia del COVID-19. Los resultados de la investigación evidencian un incremento de las tácticas de marketing de las microempresas del sector textil en el periodo objeto de análisis, especialmente en el uso de redes sociales y la implementación de páginas web para captar clientes teniendo en cuenta el fuerte impacto en las ventas por causa del COVID -19. También es importante establecer que las tendencias para mantener la relación con el cliente incrementaron el uso del marketing digital lo que hace que exista una disminución en el marketing personalizado.
Gestión del nivel de desgaste emocional del servidor público que brinda atención a mujeres en situaciones de crisis
Authors: Sanchez Trinidad Rosa del Carmen , Márquez Amaro Raymundo , Castillo Méndez Rocío del Carmen , Sánchez Cruz Samanta , Aguirre Andrade Antonio , De Dios Domínguez Wilber , Sánchez  Trinidad Adriana del Carmen
Published: September 2022

La investigación que se presenta en este artículo tiene como objetivo analizar la situación en las Direcciones de Atención a la Mujer (DAM’s) del estado de Tabasco donde existe una gran demanda del servicio para atender casos de mujeres en situaciones de crisis, por lo regular violentadas, a tal grado que la dinámica de trabajo del servidor público se ve exigida en tiempo y continuo servicio diariamente, en ocasiones, sin descanso o receso entre una y otra situación personal de cada una de las mujeres que requieren el servicio de apoyo. Lo anterior, aunado al perfil y habilidades personales del servidor público generan un nivel de desgaste físico, mental y emocional puesto que no todo el personal cuenta con el perfil profesional para la función de apoyo emocional hacia las mujeres violentadas. Por lo tanto, se consideró necesario un diagnóstico para identificar el nivel de desgaste en este puesto y poder establecer estrategias de apoyo para fortalecer las habilidades personales y desarrollar otras, requeridas por las funciones, para mejorar la calidad de vida de los servidores públicos en cada una de las DAM’S del estado de Tabasco.
Digitalización para las pequeñas y medianas empresas
Authors: Fernández-González Raquel , Puime-Guillén Félix , Fernández-Lago David
Published: September 2022

El objetivo de este artículo es conocer la rentabilidad de la implantación de una app de fidelización. Dicha aplicación ofrecerá en Galicia, una región al noroeste de España, una herramienta para que las pequeñas y medianas empresas, las que más dificultades tienen para realizar una digitalización completa de su negocio, puedan retener y atraer clientes ante un mundo en continuo cambio y retos tecnológicos; y a su vez un benéfico a los consumidores, con el cual podrán realizar sus compras teniendo un valor añadido. Para ello, se realizará un análisis de viabilidad para la elaboración de un negocio, realizando una completa proyección financiera de cinco años. Los resultados indican que el proyecto es rentable y recomendable.
Malignant Gastro-Intestinal Stromal Tumours in a middle-aged male -- A diagnostic challenge
Authors: Kalagadda Shravya , Kuchana Sai Kiran , Kode Rohith , Mamidi Shanteja Reddy , Kutikuppala L V Simhachalam , Coghlan Amina Maria Stephanie
Published: September 2022

Gastro-intestinal Stromal Tumors (GISTs), soft tissue sarcomas of the
gastrointestinal tract, represent the most frequent malignant
gastrointestinal tumors of the subepithelial lesions (SELs) and of
mesenchymal gastrointestinal tract. The size of the tumour and its
mitotic activity were initially used as risk indicators in determining
the prognosis.
A power equalization RF-PWM method with third and fifth harmonic elimination
Authors: Fu Haoyang , Zhou Qiang , Zhu Lei , Chen Zhang
Published: September 2022

To reduce the power loss of the SMPA unit, this paper proposes a power
equalization RF-PWM method with third and fifth harmonic elimination.
Based on the third and fifth harmonic cancellation, this method achieves
output power equalization of SMPA by controlling the width of 3-level
sub-pulses to be the same. Moreover, the equalization of each switch
transistor is realized by outphasing architectures. Finally, the
feasibility of the method is verified by simulation results. For QPSK
and 16QAM signals with a carrier frequency of 200 MHz, the proposed
method achieves the same output power of each SMPA unit.
A systematic review of circulating-free MYCN amplification status as a noninvasive and prominent prognostic and recurrence monitoring indicator for neuroblastoma
Authors: Zhang Wancun , Liang Ying , Zhang Pin , Zhang mengxin , Du Bang , Cheng Weyland , Wang Huanmin , Hou Guangjun , Zhang Xianwei
Published: September 2022

MYCN gene plays an important role in neuroblastoma cell growth,
apoptosis, differentiation, tumor infiltration, metastasis, and
angiogenesis. MYCN gene amplification status in tumor tissue is
one of the important clinical indicators of neuroblastoma risk. However,
there are several problems in detecting the MYCN gene in tumor
tissues, such as complex procedures in detection approaches, high
detection costs, and difficulty in obtaining tumor tissues. Studies have
shown that circulating-free MYCN gene amplification in
neuroblastoma is consistent with that in tumor tissue. Circulating-free
MYCN gene amplification has the advantages of high sensitivity,
high specificity, simple operation, and non-invasiveness as an indicator
for prognosis and recurrence of neuroblastoma. Therefore, the
application and future development of circulating-free MYCN gene
amplification status in the prognosis and recurrence monitoring of
neuroblastoma was examined in this article.
The value of 18 F-FDG PET/CT quantitative indexes in the diagnosis of non-destructive PTLD after pediatric liver transplantation
Authors: Si Zhuyuan , Lu Dongyan , Zhai Lili , Zheng Weiping , Dong Chong , Sun Chao , Wang Kai , Zhang Wei , Wei Xinzhe , Zhang Zhixin , Zhao Shengqiao , Gao Wei , Shen Zhongyang
Published: September 2022

Rationale: Post-transplant lymphoproliferative disease (PTLD)
is a serious complication after pediatric liver transplantation (pLT),
which may lead to death. F-FDG PET/CT is rarely
considered in PTLD after pLT and lacks clear diagnostic guidelines,
especially in the differential diagnosis of non-destructive PTLD. The
aim of this study was to find a quantifiable F-FDG
PET/CT index to identify non-destructive PTLD after pLT.
Materials and Methods: This retrospective study collected the
data of patients who underwent pLT, postoperative lymph node biopsy, and
F-FDG PET/CT at Tianjin First Central Hospital from
January 2014 to December 2021. Quantitative indexes were established
using lymph node morphology and the maximum standardized uptake value
(SUVmax). Results: A total of 83 patients met the inclusion
criteria and were included in this retrospective study. To distinguish
between PTLD-negative cases and non-destructive PTLD cases, according to
the receiver operating characteristic curve, [the shortest diameter of
the lymph node at the biopsy site (SDL)/the longest diameter of the
lymph node at the biopsy site (LDL)]*[SUVmax at the biopsy site
(SUVmaxBio)/SUVmax of the tonsils (SUVmaxTon)] had the maximum area
under the curve (0.923; 95% confidence interval, 0.834–1.000), and the
cut-off value was 0.264 according to the maximum value of Youden’s
index. The sensitivity, specificity, positive predictive value, negative
predictive value, and accuracy were 93.6%, 94.7%, 97.8%, 85.7%, and
93.9%, respectively. Conclusions:
(SDL/LDL)*(SUVmaxBio/SUVmaxTon) has good sensitivity, specificity,
positive predictive and negative predictive values, and accuracy, and
can be used as a good quantitative index for the diagnosis of
non-destructive PTLD.
Myocardial infarction Type II° in young patient with congenital thrombotic thrombocytopenia purpura (TTP). “Written informed consent was obtained from the patient to publish this report in accordance with the journal’s patient consent policy”. Conflict of Interest: There are no conflicts of interest to declare.
Authors: Abdo Mourad Haj , Housen Hogir , Zistler Katharina Sophie , Seidl Karlheinz
Published: September 2022

A 33-year-old female presented to our (ED) because of hypertensive
crisis with Headache.She had been having progressive shortness of breath
over 6 Months that worsened acutely on the admission day . she came to
our emercency department, and she waswith depression at the psy
How long is the appropriate duration to determine that the hormone therapy is ineffective in menopause?
Authors: Toda Katsuhiro
Published: September 2022

As a general rule in pharmacotherapy, ineffective pharmacological
treatment should be discontinued. Ineffective pharmacotherapy should not
be administered for a long time. The first problem is the appropriate
duration to determine that the pharmacological treatment is ineffective.
The second problem is the criterion for determining the efficacy (or
ineffectiveness) of the pharmacological treatment. As far as I know,
there is no evidence regarding the duration. Nevertheless, it is
necessary to determine the duration. Standards by academic organizations
are necessary, even provisional standards are acceptable. Long-term
administration of ineffective medicine causes the problem of adverse
effects. It loses the opportunity to receive effective treatment. In
case that HT is ineffective for menopause, the treatment of fibromyalgia
may relieve symptoms of menopause. Patients do not get medical attention
for the improvement of abnormal hormone levels but do for the
improvement of subjective symptoms such as widespread pain, numbness,
insomnia, and fatigue. Some people are almost asymptomatic even if their
hormone levels are abnormal. I believe that the efficacy (or
ineffectiveness) should be determined with the improvement of the
above-mentioned subjective symptoms rather than the improvement of the
abnormal hormone levels.
Case Series Profile of Olanzapine Post-Injection Delitrium/Sedation Syndrome
Authors: Seebaluck Jason , Downes Michael , Brown Jared A. , Harris Keith , Isoardi Katherine , Chan Betty
Published: September 2022

Olanzapine pamoate is an intramuscular depot injection for the treatment
of schizophrenia. Approximately 1.4% of patients develop a serious
adverse event called Post Injection Delirium/Sedation Syndrome (PDSS);
characterised by drowsiness, anticholinergic and extrapyramidal
symptoms. The objective is to investigate olanzapine PDSS presentations
including clinical features and treatment approach. This is a
retrospective review of olanzapine PDSS patients from three toxicology
units and the NSW Poisons Information between 2017 and 2022. Adult
patients were included if they had intramuscular olanzapine then
developed PDSS criteria. Clinical symptoms, treatment, timing and length
of symptoms were extracted into a preformatted Excel database. There
were 18 patients included in the series, with a median age of 49 years
(IQR: 38-58) and male predominance (89%). Median onset time post
injection was 30 minutes (IQR: 11-38). PDSS symptoms predominate with
drowsiness, confusion and dysarthria. Median length of symptoms was 24
hours (IQR: 20-54). Most common treatment included supportive care
without any pharmacological intervention (n=10), benzodiazepine (n=4)
and benztropine (n=3). In one case, bromocriptine and physostigmine
followed by oral rivastigmine were given to manage anti-dopaminergic and
anti-cholinergic symptoms respectively. This proposed treatment
combination could alleviate some of the symptoms. In conclusion, this
case series supports the characterisation of PDSS symptomology
predominantly being anti-cholinergic with similar onset (<1
hour) and duration (<72hours). A combination of bromocriptine
and physostigmine followed by rivastigmine is proposed to manage PDSS if
patients develop severe dopamine blockade or anti-cholinergic delirium.
Miejsce i znaczenie logistyki w agrobiznesie
Authors: Klepacki Bogdan
Published: September 2022

Przedstawiono agrobiznes jako specyficzny dział gospodarki narodowej. Zdefiniowano pojęcie agrologistyki, jako działalności logistycznej dostosowanej do potrzeb agrobiznesu. Zaprezentowano wyniki badań dotyczące stanu logisty-ki w przedsiębiorstwach przemysłu rolno-spożywczego. Dokonano rozpoznania sytuacji w zakresie gospodarki zapasami i gospodarki magazynowej, transportu, zarządzania informacją oraz gospodarki opakowaniami. Stwierdzono, że przemysł rolno-spożywczy napotyka problemy spowodowane rozproszeniem dostawców, stosuje zróżnicowane rozwiązania w zakresie zaopatrzenia, gospodarki zapasami, magazynowania, transportu, relacji z klientami i konsumentami czy też wykorzystania systemów wspomagania decyzji i sieci informatycznych. Stwierdzono, że relatywnie słabo wykorzystywane są nowoczesne technologie bazujące na falach radiowych, chętniej wykorzystywane są kody kreskowe. W relacjach z klientami//partnerami dominuje kontakt telefoniczny. Wśród przedsiębiorstw posiadających systemy informatyczne dominują te związane z finansami, księgowością oraz pracą biurową.
Rynek gazu ziemnego w Polsce w kontekście potrzeb energetycznych kraju
Authors: Wysokiński Marcin , Gromada Arkadiusz
Published: September 2022

Artykuł dotyczy rynku gazu ziemnego w Polsce. W pierwszej części opracowania przedstawiono znaczenie tego surowca w gospodarce jako ważnego źródła energii. Przeanalizowano także zasoby złóż gazu ziemnego w Polsce oraz jego wydobycie. W dalszej części pracy zaprezentowano strukturę dostaw gazu do Polski oraz jego zużycia na krajowym rynku. Stwierdzono m.in. rosnące zapotrzebowanie na to paliwo w branży elektroenergetycznej oraz w handlu i usługach. W artykule scharakteryzowano również rynek LNG i CNG jako część rynku gazu o specyficznych wymaganiach transportowych i magazynowych.
Logistics as a factor of optimization the operations in food complex in Ukraine
Authors: Cherevko Georgiy , Kovaliv Volodymyr , Kolodiichuk Volodymyr
Published: September 2022

Today the logistics could be an efficient method for increasing the food production and food processing and they could combine all the elements of food production sub-complex into the single chain providing conditions not only for domestic production and consumption of this strategically important products but also provide a great deal of export flows. In our opinion it is logistics that can consolidate separate components of economic mechanism and provide conditions for structural and functional balance and efficient institutional foundations. When operating logistics flows we can develop optimal cause and effect relationship among the elements that would finally create effective system. As a primary step that would enable to achieve a totally new level in logistics for the food production of Ukraine, the new scheme for transformation mechanism of logistics system in food production sub-complex of Ukraine has been suggested. It is based on “virtualization” of material flows among certified food products storehouses.
Od producenta do konsumenta: determinanty transportu żywności w XXI wieku
Authors: Górecka Aleksandra , Zych-Lewandowska Maria
Published: September 2022

Artykuł jest pracą przeglądową, w której przedstawiono zagadnienia dotyczące determinant rozwoju transportu żywności w Europie i na świecie. Wskazano problemy, które mogą wynikać z faktu tworzenia coraz bardziej złożonych łańcuchów dostaw produktów żywnościowych. Ukazano, jak duże znaczenie dla globalnego rynku ma wciąż wzrastający wolumen przewozów żywności oraz jakie miejsce w tym procesie zajmuje regionalizacja produkcji żywności. Jako podsumowanie autorki przedstawiły możliwe rozwiązania, które zastosowane globalnie mogłyby wpłynąć na ograniczenie negatywnych efektów nadmiernego rozrastania się łańcuchów dostaw żywności.
Zabezpieczenie logistyczne gospodarstw specjalizujących się w hodowli koni na przykładzie rozwiązania stosowanego w Ośrodku Jazdy Konnej w Budzistowie
Authors: Gryglak Marta , Wojciechowski Andrzej
Published: September 2022

Artykuł porusza problematykę związaną z zarządzaniem zapasami żywności dla zwierząt w gospodarstwach specjalizujących się w hodowli koni. W części teoretycznej artykułu przedstawiono teorię zabezpieczenia logistycznego oraz jego podziału, a także opisano systemy logistyczne. Kolejnym aspektem poruszonym w artykule są pojęcia magazynu oraz magazynowania zbóż. W artykule przedstawione zostały uwarunkowania dotyczące planowania zapasów. Autorzy wykonała badania dotyczące zapotrzebowania na pasze objętościowe i treściwe dla koni z Ośrodka Jazdy Konnej w Budzistowie.
Rozwój bazy magazynowej w Polsce
Authors: Klepacki Bogdan , Dziedzic-Jagocka Ilona , Piątek Edyta
Published: September 2022

W opracowaniu zaprezentowano kierunki zmian w stanie bazy magazynowej w Polsce w latach 2005–2013. Na podstawie danych statystycznych stwierdzono, że najszybciej zwiększa się powierzchnia magazynów zamkniętych w przemyśle i handlu, maleje natomiast w rolnictwie. Najszybsze było tempo wzrostu powierzchni magazynów w pierwszych latach po przystąpieniu Polski do Unii Europejskiej. W latach kryzysu światowego i po wybuchu konfliktu militarnego na Ukrainie tempo to wyraźnie zmalało. Stan bazy magazynowej jest bardzo zróżnicowany przestrzennie, najlepiej sytuacja wygląda w województwach najbardziej rozwiniętych, stąd logistyka nie przyczynia się do niwelacji różnic w przestrzennym rozwoju kraju.
The role of logistics in agricultural development in Ukraine
Authors: Slavkova Olena , Solovey Maryna
Published: September 2022

The article considers the problem of an efficient system of agricultural logistics formation that is currently in Ukraine in the process of development. Demand for logistics integration in modern conditions becomes a necessity while further agricultural sector development without implementation of logistic functions becomes ineffective. In the logistics system formation in the agricultural sector purely market institutions for the coordination of relationships are of crucial significance. Government policies can act as a catalyst for the creation of logistic chains. Macrolevel requires state regulation mechanisms for the sustainable use of limited resources and socio-economic development of territories. The negative factors of logistics development in Ukraine are the lack of licensing, available IT-solutions, outdated stocks, poor training of specialists. Thus, in today’s agricultural environment, logistics is a new concept that is undergoing significant changes in short period of time.
Jakość logistycznej obsługi klienta w firmie Poczta Polska S.A. w opinii klientów
Authors: Wysokiński Marcin , Lengiewicz Katarzyna
Published: September 2022

Dla klientów korzystających z usług przedsiębiorstw oferujących usługi logistyczne coraz większe znaczenie ma nie tylko cena oferowanych usług ale również ich jakość. Sytuacja ta dotyczy między innymi podmiotów prowadzących działalność na rynku KEP. W przypadku logistycznej obsługi klienta jakość oferowanych usług ma bardzo duże znaczenie. W pracy przedstawiono ocenę systemu logistycznej obsługi klienta na przykładzie przedsiębiorstwa Poczta Polska S.A. Oceny podmiotu dokonano na podstawie wyszczególnionych elementów logistycznej obsługi klienta takich jak: czas, niezawodność, komunikacja oraz wygoda. Przedstawione analizy przeprowadzono na podstawie badań ankietowych. Otrzymane wyniki pozwoliły na ocenę jakości oferowanych przez przedsiębiorstwo usług w opinii klientów.
Wybrane aspekty procesów wchodzenia zachodnich operatorów na polski rynek logistyczny
Authors: Bielicki Maciej
Published: September 2022

Przemiany, jakie miały miejsce w Polsce począwszy od 1990 roku (w szczególności wprowadzenie wolnej konkurencji i otwartego rynku w gospodarce), spowodowały konieczność prowadzenie działalności (także w branży TSL) według poprawnych ekonomicznie zasad, będących standardem w krajach zachodnich, ale w większości niestosowanych wcześniej w naszym kraju. Następowało to między innymi poprzez napływ know-how wraz z pojawianiem się na naszym rynku renomowanych zachodnich operatorów logistycznych. Podczas procesu wchodzenia na polski rynek firmy te napotkały jednak nieznane im wcześniej problemy ze zrozumieniem specyfiki nowego rynku i istniejących barier, które utrudniły im dopasowanie swoich zasad, standardów i procedur do lokalnych.
Green wave in urban traffic
Authors: Jereb Borut , Bratina Tadej , Kumperščak Samo
Published: September 2022

Over 70% of the European population lives in urban areas. This puts pressure on urban transport systems, leading to increased environmental impacts. Such impacts are particularly large in cases where the traffic caused by vehicles with internal combustion engines is repeatedly braking and accelerating due to poorly planned traffic flow. We do not know exactly how much of the pollution is increased by braking and accelerating vehicles at traffic lights; on the other hand, we can evaluate the contribution of higher fuel consumption. We have evaluated such an increase in fuel consumption in the real case of a road section in Celje. Based on the obtained results, we are able to estimate the factor of pollution increasing caused by accelerating. By adding the estimates of pollution caused by braking, we get an overall picture of the importance of ensuring a steady flow of traffic to reduce pollution in urban environments.
Pozyskiwanie i wykorzystanie funduszy Unii Europejskiej jako przejaw przedsiębiorczości jednostek samorządu terytorialnego
Authors: Sikorska-Wolak Izabella , Cyburt Agnieszka
Published: September 2022

W artykule przedstawiono zagadnienie przedsiębiorczości władz lokalnych w obszarze pozyskiwania i wykorzystywania funduszy Unii Europejskiej. Dokonano oceny dotychczasowej aktywności władz lokalnych w absorpcji środków pomocowych. Wskazano potencjalne czynniki determinujące aktywność jednostek samorządu terytorialnego oraz ich ocenę z punktu widzenia mieszkańców.
City placement jako forma promocji regionu
Authors: Werenowska Agnieszka
Published: September 2022

Prowadzenie przemyślanych i zaplanowanych działań promocyjnych stało się koniecznością w sytuacji, kiedy nie tylko przedsiębiorstwa, ale i miasta oraz regiony chcą utrzymać wysoką pozycję w kluczowych grupach otoczenia. City placement to szczególny przejaw lokowania produktu lub określonego miejsca w filmie, serialu, programie, książce, teledysku czy grze komputerowej. Może być to miasto lub region. Korzystają z tego rodzaju promocji również małe miasteczka, a nawet wsie. W artykule zaprezentowano city placement jako współcześnie jedno z bardziej popularnych narzędzi promocji miast i regionów. Wykorzystano analizę literatury przedmiotu oraz dane z cyklicznego raportu na temat promocji miast w serialach opublikowanym przez Press Service Monitoring Mediów.
Optimization of excess brines disposal methods at potash mining and processing plants
Authors: Shcherban Pavel , Gapchich Alexander , Zhdanov Aleksey , Letunovskaya Olga
Published: September 2022

The paper analyzes the positive and negative aspects of various technological solutions for the liquid brines used during the development of polymineral potash ore deposits and considers the problem of determining the choice of the optimal approach by considering geological, technical, environmental, and financial factors. The study of the issues of utilization and reduction of the liquid brines components of discharges in the production of potash fertilizers, the simultaneous reduction of valuable components loss with liquid discharges, and, due to this, increasing the production of potash fertilizers, and the usage in the technology of mine brines, are an urgent and important scientific and engineering challenge of the potash industry. Technologically, several alternative solutions can reduce the number of liquid by-products placed in sludge storage. The work used analytical methods, including statistical data processing, modeling, pre-design studies of technological solutions, and assessment of economic costs. Excess brines of potash mining and processing plants are liquid waste obtained during the production of potash fertilizers ? MOP ? SOP. The accumulation of excess brines in sludge storage facilities is estimated at millions of cubic meters per year. However, the expansion of the sludge storage facilities area and the construction of dams are only temporary solutions. They are associated with risks in the design, construction, and operation of hydraulic structures, increasing the risks of brine leakage into open and underground water basins. Therefore, it makes it necessary to use other methods of brine disposal. Depending on the nature of the processed polymineral potash ores, several methods can be combined to dispose of excess brines at once: backfilling, osmosis, injection into deep horizons, and multistage evaporation. The most optimal combination of brine reduction technologies for potassium-magnesium processing plant's raw materials is the following: 60% is disposed of by usage of vacuum evaporation units, 20 % by injecting excessive brines into deep absorbing horizons, and 10%?20% should be used for backfilling or additional products production.
Spatial patterns of entertainment mobility in cities
Authors: Todoric Jovana , Yamashkin Anatoliy , Vuksanovic-Macura Zlata
Published: September 2022

Cultural and entertainment activities have become an important part of the
life of the city's population. Spaces of entertainment are being developed
in almost all parts of the city-in the inner city, in larger neighborhoods
both in the city center and on the outskirts, near the centers of labor,
shopping areas (e.g., attractive streets or shopping malls), or recreation
areas. Hence the need to research the spatial patterns of entertainment
mobility in the city. Studies to date have found that people spatially
adjust their consumer activities (including entertainment) to their primary
functions (housing, going to work, school, and college). This paper examines
mobility for the entertainment of various socio-economic groups (employees,
students, unemployed, and pensioners). Attention is also focused on
examining the neighborhood's entertainment mobility-near the place of
residence. The paper uses data from the survey on daily population mobility
in the territory covered by the General Plan of Belgrade (GPB), Serbia,
conducted in 6,357 households. The main part of the research is the spatial
analysis of the patterns of residents? mobility for entertainment. Spatial
analyses is based on mapping of entertainment movements, and then
interpreting the obtained cartographic representations. Based on that,
regularities are recognized, i.e., spatial patterns of entertainment in the
city.
Timing of clinical eruption of permanent teeth in children with molar incisor hypomineralization
Authors: Şenyurt Tazegül , Hazar Bodrumlu , Demiriz Levent
Published: September 2022

Introduction/Objective. Molar incisor hypomineralization (MIH) is a developmental defect and it has a multifactorial etiology; there could be variations in dental eruptions in the children with this condition. The aim of this study was the comparison of the clinical eruption status of the permanent teeth in children with MIH and patients without MIH. Methods. The study group comprised a total of 300 children (176 females and 124 males aged 6?12 years) who had been diagnosed with MIH but had no systemic disease. The control group comprised 300 age- and sex-matched children without MIH. In the study and control groups, the eruption of the permanent teeth (excluding third molars) was evaluated and compared. In addition, this comparison was performed separately for the males and females in the study and control groups. The independent samples t-test was used for statistical analysis. Results. No statistically significant difference was found between the mean age of the dental eruptions of the children with MIH and that of the children without mineralization disorders (p > 0.05). Regarding the mean age of the dental eruptions, the sex-matched comparison revealed no statistically significant difference between the study and control groups (p > 0.05). Conclusion. Although there was no statistically significant difference in the MIH group and the healthy control group regarding the mean age of the eruption of all teeth, a trend of accelerated dental development in the MIH group was observed.
Current aspects of radiobiology in modern radiotherapy - our clinical experience
Authors: Nikitovic Marina , Stanojkovic Tatjana
Published: September 2022

Personalized radiation treatment is an important goal in radiation oncology. As a result, one of the main challenges in radiobiology today is predicting a patient?s tissue radiosensitivity so that a personalized treatment can be tailored to that individual. For the first time since 2016, a group from the Institute of Oncology and Radiology of Serbia has begun performing translational research in the field of radiobiology. The aim of these studies is to identify molecular markers important for the prediction of radiosensitivity as well as the occurrence of toxic effects of radiotherapy. In the past five years, significant international cooperation has been established with the Radiogenomic Consortium, as well as leading European and world experts in this field. In addition, during this period, several significant and promising results in this field were published, and a Laboratory for Radiobiology was established at the Institute of Oncology and Radiology of Serbia.
Microanatomical characteristics of arterial vascularization of the anterior cruciate ligament
Authors: Laketic Darko , Simic Marko , Boljanovic Jelena , Jovic Darko , Alexopoulos Christos , Vitosevic Biljana , Zelenovic Aleksandra , Dinic Ljubomir , Milisavljevic Мilan
Published: September 2022

Introduction/Objective. The aim of this study was to examine the immunohistochemical features of the vascularization of the anterior cruciate ligament (ACL), as well as the quantification of capillaries within the three segments of the ACL; proximal, middle and distal. The quantification and metric characteristics of mast cells of the ACL are the second goal of this research. Methods. In total, 30 human ACL of 30 persons, obtained during routine autopsy, were examined under the microscope, following immunohistochemical reactions against CD34 of blood vessels and MastTrip of mast cells. Results. The middle genicular artery close to the ACL gave off branches for the supply of ligament itself. Each field of mm2 contained an average number of 1113.84 (959?1240), microvessels in ACL proximal third, an average number of 1145.43 (924?1310) microvessels in ACL middle third, and an average number of 1134.55 (889?1451) microvessels in ACL distal third. An average number of mast cells of the ACL was 3.8 per mm2. In the peripheral synovial zone of the ACL, we counted 12.6 mast cells per mm2. An average area value of the mast cells was 124.7 ?m2, and an average value of shorter and longer axis of the mast cells was 11.2 ? 15.0 ?m. Conclusion. There was no statistically significant differences between the average numbers of intraligamentous microvessels of the ACL thirds (p > 0.05), confirming and supporting our hypothesis of uniform distribution of blood supply within the ACL.
Incidental finding of pulmonary tumorlet in a case of surgically treated bronchiectatic cavity superimposed by aspergilloma
Authors: Moskovljevic Dejan , Colic Nikola , Dimkic-Milenkovic Andjela , Markovic Jelena , Milenkovic Vladimir
Published: September 2022

Introduction. Intracavitary aspergilloma is the consequence of a saprophytic infection of the lung with cavitary disease. Pulmonary tumorlet are nodular proliferations of the neuroendocrine cells less than 5 mm in diameter. Both aspergilloma in the bronchiectatic cavity of the lung and pulmonary tumorlet has rare been seen. Case outline. We present a 71-year-old woman with a medical history of recurrent pneumonia complicated with cough and hemoptysis. Computed tomography (CT) scan of the chest showed pulmonary soft tissue mass in the right lower lobe of the lung 42 ? 50 mm in diameter. Direct microscopy of the specimens of bronchioalveolar lavage showed spores of Aspergillus. Galactoman Ag test was also positive. Right lower lobectomy and mediastinal lymph node sampling was performed via thoracotomy. Pathohistological findings showed aspergilloma with the presence of pulmonary tumourlet and diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) in the lymphovascular spaces. Five years follow up showed no abnormalities on the CT scan, and the patient remained alive without medical problems. Conclusion. The concomitant occurrence of bronchiectasis, aspergilloma, and precancerous lesions such as pulmonary tumourlet and DIPNECH is rare and further increases the risk of developing malignant tumors as well as recurrent infections. Therefore, surgical treatment can prevent the development of premalignant lesions and the occurrence of recurrent infections accompanied by dyspnea and hemoptysis as the main symptoms. The question of the connection between pulmonary tumourlet and chronic inflammatory lung diseases is raised. We hope that future researches will provide answers to this question.
Translation, transcultural adaptation, and validation of the Serbian version of the PSS-QoL questionnaire: A pilot research
Authors: Vujovic Sanja , Desnica Jana , Mijailovic Sara , Milovanovic Dragan
Published: September 2022

Background/Aim. The assessment of health-related quality of life (HRQoL) is fundamental for a better understanding of the effect of a disease on different aspects of a patient?s daily functioning and the efficacy of the treatment modalities. Primary Sj?gren?s Syndrome (SS) Quality of Life Questionnaire (PSS-QoL) is the first disease-specific instrument for evaluating HRQoL in patients with primary SS. The aim of this study was to formally translate the PSS-QoL questionnaire from English to Serbian, assess its psychometric properties, and validate it for use in the Serbian population. Methods. The research was designed as a pilot study and included 30 participants. Internal consistency was determined by calculating Cronbach?s alpha coefficient. The construct validity of the questionnaire was estimated by the correlation of its overall result with the patients? EuroQoL- 5D, European League Against Rheumatism (EULAR) SS Patient Reported Index, Oral Health Impact Profile-14, and Emotion Regulation Questionnaire scores. Results. There were 29 (96.7%) female participants and one (3.3%) male participant in the research. The average (? standard deviation) score of PSS-QoL was 44.63 ? 12.901 at baseline and 41.70 ? 12.075 at follow-up. Cronbach?s alpha value of the Serbian version of PSS-QoL was 0.922. The test-retest intraclass correlation coefficient was 0.981 (95% confidence interval: 0.436?0.996). Analysis revealed a statistically significant moderate to strong correlation between PSS-QoL scores and EuroQol-5D (rs = -0.696), EULAR SS Patient Reported Index (rs = 0.883), and Oral Health Impact Profile-14 scores (rs = 0.809). Conclusion. Serbian adaptation of the PSS-QoL instrument can be used to evaluate HRQoL of patients with primary SS both in academic re-search and clinical practice as a novel outcome measure.
Islet Autoantibody Levels Differentiate Progression Trajectories in Individuals with Presymptomatic Type 1 Diabetes
Authors: Kwon Bum Chul , Achenbach Peter , Anand Vibha , Frohnert Brigitte I. , Hagopian William , Hu Jianying , Koski Eileen , Lernmark Åke , Lou Olivia , Martin Frank , Ng Kenney , Toppari Jorma , Veijola Riitta
Published: September 2022

Our previous data-driven analysis of evolving patterns of islet autoantibodies (IAbs) against insulin (IAA), glutamic acid decarboxylase (GADA) and islet antigen 2 (IA-2A) discovered three trajectories characterized by either multiple IAbs (TR1), IAA (TR2), or GADA (TR3) as the first appearing autoantibodies. Here we examined the evolution of IAb levels within these trajectories in 2,145 IAb-positive participants followed from early life and compared those who progressed to type 1 diabetes (n=643) to those remaining undiagnosed (n=1,502). Using thresholds determined by 5-year diabetes risk, four levels were defined for each IAb and overlayed onto each visit. In diagnosed participants, high IAA levels were seen in TR1 and TR2 at ages <3 years, whereas IAA remained at lower levels in the undiagnosed. Proportions of dwell times (total duration of follow-up at a given level) at the four IAb levels differed between the diagnosed and undiagnosed for GADA and IA-2A in all three trajectories (p<0.001), but for IAA dwell times differed only within TR2 (p<0.05). Overall, undiagnosed participants more frequently had low IAb levels and later appearance of IAb than diagnosed participants. In conclusion, while it has been long appreciated that the number of autoantibodies is an important predictor of type 1 diabetes, consideration of autoantibody levels within the three autoimmune trajectories improved differentiation of IAb positive children who progressed to type 1 diabetes from those who did not.
Most Prevalent Risk Factors for the Appearance of this Vaginal Discharge Syndrome: Literature Review
Authors: M Uriel
Published: September 2022

Vaginal discharge is a very common medical query. Frequently, pharmacologic treatment is well performing, but in a short period of time, symptoms and signs repeat becaus e risk factors continue. The knowledge of risk factors for the appearance of this vaginal discharge syndrome is vital to a brilliant medical approach.
Effects of Vitamin D3 Supplementation on Antioxidant Status and Lipid Peroxidation Product in Preeclamptic Women
Authors: AA Sonuga
Published: September 2022

Background: O xidative stress plays a causative role in the pathophysiology of preeclampsia. This study aime d at assessing the effects of vitamin D supplementation on the antioxidant status and lipid peroxidation product of preeclamptic women. Methods: Ninety women between ages of 18 and 35 were recruited at 22weeks gestation from antenatal Clinic in Obstetrics and Gynecology Department of University College Hospital Ibadan, and Adeoyo Maternity Clinic, Yemetu, Nigeria. 30 normotensive pregnant women were grouped into Group A, and 60 preeclamptic women randomly grouped into Group B and Group C. Group C was given 1000IU/day of Vitamin D3 for 8weeks after recruitment at 22 weeks. Serum concentration of antioxidants were done by standard methods at 22 weeks, 30 weeks after supplementation and postpartum in all groups. They were followed up 3 - 7days postpartum, and obstetric data collected. Statistical analysis was done by using Statistical Package for Social sciences (SPSS) soft version 17 .0. Results: There was no significant difference (p>0.05) in gestational age at delivery, weight of fetus between the three group s, while there was a significant increase (p<0.05) in BMI, systolic and diastolic blood pressure in group B and C. The level of Malonaldehyde (MDA) was significantly higher (p<0.05), while SOD, GPX and catalase were lower in the preeclamptic groups at 2nd trimester when compared with control. After supplementation the MDA levels reduced significantly (p<0.05), while SOD, GPX and catalase increased significantly (p<0.05) in 3rd trimester and postpartumly in the supplemented group when compared with non - supplemented group. Vitamin C levels were not statistically different (p>0.05) at 2nd, 3rd trimester and postpartum, while Vit. E was significantly reduced (p<0.05) at the 3rd trimester in the control group. The level of Vit. E was significantly increased (p<0 .05), while Vit. C level was not statistically different (p>0.05) at 2nd trimester in the PE groups when compared with control. After supplementation, a significant increase (p<0.05) occurred in Vit. E, while Vit. C level was not statistically different (p >0.05) when compared with the non - supplemented PE group.Conclusion: Vitamin D supplementation is important in improving the antioxidant status in Preeclampsia.
Critical Appraisal of Obstetric Hysterectomy from a North Indian Tertiary Care Health Facility over a Fifteen Year Period
Authors: S Marwah
Published: September 2022

Aims & Objectives: (a) To critically analyse obstetric hysterectomies in a tertiary care government centre over a period of one year in relation to incidence, indication and risk factors, and maternal and perinatal outcome. (b) To compare the present data with similar data collected seven years and fourteen years back in same hospital. Methods: All the patients undergoing obstetric hysterectomy during the period from January 2016 to December 2016 in department of Obstetrics and Gynaecology, VMMC and Safdarjung Hospital, New Delhi were included in th e study. Their detailed obstetric history, indications leading to hysterectomy, risk factors, postoperative maternal complications and perinatal outcome was noted, analysed and compared to similar data collected in the year 2001 and 2008 in Safdarjung hosp ital. Results: The incidence of obstetric hysterectomy in the year 2016 was 1.89/1000, 0.8/1000 deliveries in 2008 and 1.5/1000 deliveries in 2001. Maternal mortality was 34.6% in 2016, 18.28% in 2008 while 20.68% in 2001. The main indications leading to hysterectomy were rupture uterus, atonic postpartum haemorrhage (PPH), abnormal placentation, secondary PPH all these years. Perinatal outcome was comparable over the 15 year study period. Conclusion: Though incidence of obstetric hysterectomy had slightl y decreased over the years initially, but owing to influx of more unbooked cases in grave condition, it has shown a gradual increase in 2016. This underlines the absence of much necessitated improvement in the community health services, which is especially evident by high percentage of obstructed labour cases contributing to hysterectomy.
The Effectiveness of Traditional Chinese Medicine for Threatened Abortion: A Systematic Review and Meta - Analysis
Authors: MENG Wei
Published: September 2022

Background: Threatened abortion is a common complication during early pregnancy. Conventional managements for the miscarriage include bed rest, hormone therapy and muscle relaxants. Traditional Chinese medicine (TCM) is also the popular option for the women. Evidence to support the efficacy and safety of TCM in treating threatened abortion is still limited. Objective: The study aimed to evaluate the safety and effectiveness of Chinese medicine in the treatment of threatened abortion compared with the hormone therapy t hrough a systematic review and meta - analysis. Methods: The randomized controlled trials (RCTs) were electronically retrieved in the database of China National Knowledge Infrastructure (CNKI), Wan Fang Database (Chinese Ministry of Science and Technology), VIP Data and PubMed between January 1 2008 and December 1 2018 with the pre - designed search strategy. The outcomes included the clinical effectiveness, the clotting time of vaginal bleeding, pain reduction in lower abdomen, and incidences of adverse event s. The software RevMan 5.1 was employed for the meta - analysis. Results: Twenty - three studies were included in the systematic review and meta - analysis, which enrolled 2014 pregnant women (1006 in the treatment group and 1008 in the control). The meta - analys is of clinical effectiveness showed that TCM significantly decreased rate of miscarriage compared with the conventional therapy. In the subgroup analysis of miscarriage rate in women, oral administration of TCM was more effective than either the injected o r oral administration of conventional medications. Further analysis showed that oral TCM was more effective than the injection of progesterone only or combined with hCG, even the oral progesterone. Conclusions: The study indicated that TCM was likely more effective than conventional therapy in treating threatened abortion with unclear adverse events. However, due to the low quality of included studies, larger scales of RCTs and more scientific evidence are needed to prove the efficacy and safety of TC M for threatened abortion.