bluuebunny/crossref_metadata_2025 huggingface dataset:
Flow Control Mechanism of Blade Tip Bionic Grooves and Their Influence on Aerodynamic Performance and Noise of Multi-Blade Centrifugal Fan
Authors: Xu Ziqian , Liu Xiaomin , Liu Yang , Qin Wanxiang , Xi Guang
Published: May 2022

To improve the aerodynamic performance and reduce the noise of multi-blade centrifugal fans used in air conditioners, a bionic groove structure was introduced into the blade tip design, inspired by the drag reduction characteristics of mantis shrimp. In this paper, the numerical method was used to investigate the effects of a blade tip bionic groove on the aerodynamic performance and noise characteristics of a multi-blade centrifugal fan. Firstly, the basic design parameters, such as groove width, groove depth, groove center distance, and groove number, were selected to define the shape of the blade tip bionic groove. Then, the effect of the design parameters on the aerodynamic performance of the multi-blade centrifugal fan was studied. Finally, the multi-blade centrifugal fan models with different groove shapes, such as rectangular bionic grooves, circular bionic grooves, and triangular bionic grooves, were established to compare the influence of blade tip groove structures on the aerodynamic performance of the multi-blade centrifugal fan. Through analysis of the aerodynamic performance and noise characteristics of the multi-blade centrifugal fan and the flow fields in the fan impeller, the flow control mechanism of the blade tip bionic groove was revealed. The results showed that the triangular bionic groove on the blade tip had a certain noise reduction effect, although the structural parameters of the bionic groove had little effect on the aerodynamic performance of the multi-blade centrifugal fan. This is because the triangular bionic groove structure can effectively inhibit the vortex shedding at the trailing edge of blade and reduce the flow separation in the impeller passages. As a result, the velocity distribution at the impeller tip became more uniform and the intensity of the tip vortex and the shedding vortex was weakened. Correspondingly, the noise of multi-blade centrifugal fan was also reduced to some extent.
Synchronizing Torque-Based Transient Stability Index of a Multimachine Interconnected Power System
Authors: Poulose Albert , Kim Soobae
Published: May 2022

Newly developed tools and techniques are continuously established to analyze and monitor power systems’ transient stability limits. In this paper, a model-based transient stability index for each generator is proposed from the synchronizing torque contributions of all other connected generators in a multi-machine interconnected power system. It is a new interpretation of the generator’s synchronizing torque coefficient (STC) in terms of electromechanical oscillation modes to consider the synchronizing torque interactions among generators. Thus, the system operator can continuously monitor the system’s available secured transient stability limit in terms of synchronizing torque more accurately, which is helpful for planning and operation studies due to the modal based index. Furthermore, the popular transient stability indicator critical clearing time (CCT), and the traditionally determined synchronizing torque values without other generator contributions, are calculated to verify and compare the performance of the proposed transient stability index. The simulations and test result discussions are performed over a western system coordinating council (WSCC) 9-bus and an extensive New England 68-bus large power test system cases. The open-source power system analysis toolbox (PSAT) on the MATLAB/Simulink environment is used to develop, simulate, validate and compare the proposed transient stability index.
An Accurate Method for Computing the Delay Margin in Load Frequency Control System with Gain and Phase Margins
Authors: Khalil Ashraf , Laila Dina Shona
Published: May 2022

In traditional power systems, a dedicated communication channel is utilized to transfer the frequency measurements. With the deregulation and reconstruction of power systems, the information is sent through a shared communication network that makes time delays unavoidable in load frequency control (LFC) systems. With the existence of time delays, the LFC system becomes a standard time delay system that complicates the stability analysis and controller synthesis. In this paper, we present a new approach for analyzing the stability and determining the delay margin of the LFC system. By introducing a new variable, the transcendental equation is converted to nonlinear equations. To find the crossing frequencies, the nonlinear equations are solved, which is simpler than solving a set of linear matrix inequalities. A single-area and a multi-area LFC system are selected as case studies. The new method accurately determines the delay margin of the LFC system with phase and gain margin. The effect of the PI controller gains on the delay margin is also considered. A sensitivity analysis is conducted to discover the effects of the system parameters on the delay margin, and it is found that the primary loop parameters have a powerful influence on the delay margin. The stability region of the LFC system is also clearly identified through the proposed method. The influence of the system parameters on the stability region is studied. Compared to the published methods in the literature, the proposed method has a simpler structure while giving more accurate results.
A Bibliometric Review of Energy Related International Investment Based on an Evolutionary Perspective
Authors: Yang Zijie , Huang Dong , Zhao Yuqing , Wang Wenqian
Published: May 2022

Energy security could be jointly maintained through the cooperation of different countries or regions. In this circumstance, there has been a large number of energy-related international investment studies. However, the existing academic literature lacks a systematic scientometric analysis of this research topic, so this paper will fill this gap. Using CiteSpace, VOSviewer, and HisCite, this paper analyzes 1014 articles published in the WoS SSCI Collection from January 1998 to March 2022 on the energy-related international investment. This paper comprehensively analyzes this field from four evolutionary dimensions. In the discipline and mainstream journals dimension, the largest change lies in the fact that more than three different disciplines flow into mathematics, while the journal “Environmental Science and Pollution Research” shows a dramatic growth in relevant publications after 2015. Keyword evolution shows a gradual deepening emphasis from attracting energy-related international investment to systematically analyzing the influencing mechanisms of the international investment-energy-environmental quality nexus. Citation clusters identifies two latest clusters, including institutional quality and renewable energy consumption. Citation paths summarize four major evolutionary paths. The overall evolution trend is based on the FDI-energy-environment nexus, and gradually considers the influence mechanism of different factors on this nexus.
Research on Fault-Tolerant Field-Oriented Control of a Five-Phase Permanent Magnet Motor Based on Disturbance Adaption
Authors: Zhang Li , Dong Chenyang , Wang Yucheng , Han Sai
Published: May 2022

To ensure the high-quality output performance of the five-phase fault-tolerant permanent magnet synchronous motor (FTPMSM) drive system under normal and open-circuit faults and achieve the minimal reconfiguration of the FTPMSM control drive system under various open-circuit faults, in this paper, a fault-tolerant field-oriented control (FOC) strategy based on disturbance adaption is proposed. The speed-loop and current-loop steady-healthy controllers are designed to effectively suppress the torque ripples caused by open-circuit faults and improve the robustness of the drive system to load disturbance and motor parameter variation under fault operation. Moreover, the additional zero-sequence current controller can be omitted. In addition, the modified reduced-order coordinate transformation matrices are proposed to weaken the influence of oscillating neutral. Finally, the fault-tolerant FOC system of the FTPMSM is established, and its experiment is conducted. The experimental results verify the feasibility and effectiveness of the proposed control strategy.
Power Interference Suppression Method for Measuring Partial Discharges under Pulse Square Voltage Conditions
Authors: Li Linao , Wei Xinlao
Published: May 2022

Partial discharge (PD) is an important metric for the insulation diagnosis of power equipment. However, its detection is affected by the strong electromagnetic interference generated by pulse square voltage. We therefore propose a power interference suppression method for partial discharges under pulse square voltage based on a quadratic measurement method. We conduct analysis of the topology circuit when partial discharge occurs in the insulation test sample and introduce the basic principle of the secondary measurement method according to the superposition principle and the linear relationship between the square voltages at different peak values. We verify the feasibility of this method by simulating a PD signal with power interference. Subsequently, we use the successive interception comparison method to solve the non-correspondence of the two initial measurement points problem and design and manufacture the transformer turn-to-turn oil-paper insulation test sample and experimental tank. By measuring the PD starting voltage of the insulation test sample under the power frequency voltage, we determined the first measurement voltage under the pulse square voltage and obtained the signal x1(t) to subsequently measure the PD signal x2(t). According to the proposed successive interception comparison method, the signal x1(t) is processed, and the secondary measurement method suppresses the power interference of the measured signal x2(t). We demonstrate that the proposed method effectively suppresses the power interference in PD detection under a pulse square voltage.
Study of Methane Fermentation of Cattle Manure in the Mesophilic Regime with the Addition of Crude Glycerine
Authors: Romaniuk Wacław , Rogovskii Ivan , Polishchuk Victor , Titova Liudmyla , Borek Kinga , Wardal Witold Jan , Shvorov Serhiy , Dvornyk Yevgen , Sivak Ihor , Drahniev Semen , Derevjanko Dmytro , Roman Kamil
Published: May 2022

The urgency of the study is due to the need to increase the productivity of biogas plants by intensifying the process of methane fermentation of cattle manure in mesophilic mode by adding to it the waste from biodiesel production: crude glycerine. To substantiate the rational amount of crude glycerine in the substrate, the following tasks were performed: determination of dry matter, dry organic matter, and moisture of the substrate from cattle manure with the addition of crude glycerine; conducting experimental studies on biogas yield during fermentation of cattle manure with the addition of crude glycerine with periodic loading of the substrate; and development of a biogas yield model and determination of the rational composition of crude glycerine with its gradual loading into biogas plants with cattle manure. The article presents the results of research on fermentation of substrates in a laboratory biogas plant with a useful volume of 30 L, which fermented different proportions of crude glycerine with cattle manure at a temperature of 30 °C, 35 °C, and 40 °C. The scientific novelty of the work is to determine the patterns of intensification of the process of methane fermentation of cattle manure with the addition of different portions of crude glycerine. A rapid increase in biogas yield is observed when the glycerol content is up to 0.75%. With the addition of more glycerine, the growth of biogas yield slows down. The digester of the biogas plant, where experimental studies were conducted on the fermentation of substrates based on cattle manure with the addition of co-substrates, is suitable for periodic loading of the substrate. As a rule, existing biogas plants use a gradual mode of loading the digester. Conducting experimental studies on biogas yield during fermentation of cattle manure with the addition of crude glycerine with periodic loading of the substrate makes it possible to build a mathematical model of biogas yield and determine the rational composition (up to 0.75%) of crude glycerine with its gradual loading in biogas plants. Adding 0.75% of crude glycerine to the substrate at a fermentation temperature of 30 °C allows to increase the biogas yield by 2.5 times and proportionally increase the production of heat and electricity. The practical application of this knowledge allows the design of an appropriate capacity of the biogas storage tank (gasholder).
Special Issue “Impact of Endometriosis on Women’s Health”
Authors: Wada-Hiraike Osamu , Iwase Akira
Published: May 2022

Endometriosis is one of the most common diseases in women of reproductive age, and although there are many theories to explain this enigmatic disease, such as reflux theory, metastasis theory, and metaplasia theory, there is still no single theory that can wholly explain the pathogenesis of the disease, and it is considered a mysterious disease until now [...]
Polylactide as a Substitute for Conventional Polymers—Biopolymer Processing under Varying Extrusion Conditions
Authors: Kosmalska Daria , Janczak Katarzyna , Raszkowska-Kaczor Aneta , Stasiek Andrzej , Ligor Tomasz
Published: May 2022

The polymer processing industry is paying more attention to biodegradable materials synthesized from renewable sources. One of the most popular of them is polylactide (PLA). Except the material from which a given product is made, particularly important is the process of manufacturing a polymer material, processing, use by the consumer, and finally, recycling it. Neither of these steps is indifferent to the environment. The processing of polymers can often lead to material degradation, which affects the properties of the material and leads to the generation of substantial amounts of post-production waste that cannot be reused by processors. The aim of this work is to evaluate selected properties of PLA subjected to the extrusion process under variable extrusion conditions. This is important due to the large losses of material and energy resulting from the extrusion of biodegradable polymers under poorly selected processing conditions, which, apart from the economic effects, has a negative impact on the environment. The research proved that both the temperature and the structure of the plasticizing system as well as the rotational speed of the screws affect the mechanical properties of the final product. For PLA optimization, this process will directly contribute to the improvement of the PLA processing process, and indirectly help to act for the benefit of the environment by reducing the consumption of energy, raw materials, and the amount of post-production waste. The obtained results allowed for the selection of appropriate parameters depending on the expectations regarding the properties of the final product. The conducted research will help to optimize processing processes and reduce the consumption of raw materials, which in the future will also affect the environment.
A Scenario-Based Analysis of Forest Product Transportation Using a Hybrid Fuzzy Multi-Criteria Decision-Making Method
Authors: Akay Anil Orhan , Demir Murat
Published: May 2022

The aim of this study is to reveal the weight values of the criteria that are effective in selecting the most suitable vehicle types in forest products transportation by using hybrid fuzzy multi-criteria decision-making method. According to different scenarios, the goal is to determine which vehicle alternative is the most suitable in given conditions. In the results obtained from the study, it is determined that the most important main criterion in determining the eligibility of vehicle alternatives in forest products transport is the environmental damage criterion, while the other main criteria are cost and operational performance, in order of importance. In the scope of the study, transportation scenarios including different operational conditions were created and the suitability of vehicle alternatives was evaluated according to the scenarios, taking into account CO2 emission and road surface damage risk criteria. Transportation of coniferous and broadleaved tree species makes a difference in vehicle suitability rankings according to transportation scenarios. In addition, it was observed that the variability in the amount of roundwoods to be transported affects the vehicle suitability rankings. It will be beneficial to consider the total weight of the forest product to be transported and the tree species in the selection vehicle type.
Decay Resistance of Nano-Zinc Oxide, and PEG 6000, and Thermally Modified Wood
Authors: Reinprecht Ladislav , Repák Miroslav , Iždinský Ján , Vidholdová Zuzana
Published: May 2022

In Central Europe, European beech (Fagus sylvatica L.) wood has a high potential for the production of construction and decorative materials, with the aim of replacing Norway spruce, oaks, and other traditionally used tree species. However, the biological resistance of beech wood—to decaying fungi, molds, and insects—is low, and in damp conditions its resistance must be increased with suitable preservatives or modification methods. In the present experiment, beech wood was first treated with water systems of nano-zinc oxide (0.1 to 3.3 wt.% of nano-ZnO) and/or polyethylene glycol 6000 (20 wt.% of PEG 6000), without/with additional thermal modification at 190 °C/2 h. In the presence of nano-ZnO, the decay resistance of beech wood to the brown-rot fungus Rhodonia placenta and the white-rot fungus Trametes versicolor significantly increased, mainly after its additional thermal modification. The presence of nano-ZnO in beech wood—(a) alone, (b) with a subsequent application of PEG 6000, (c) with additional thermal modification—had a more apparent inhibition effect on T. versicolor than on R. placenta. PEG 6000 alone did not improve the resistance of beech wood to rot.
A Data-Driven Model for Spatial Shallow Landslide Probability of Occurrence Due to a Typhoon in Ningguo City, Anhui Province, China
Authors: Cui Yulong , Jin Jiale , Huang Qiangbing , Yuan Kang , Xu Chong
Published: May 2022

From 9 to 11 August 2019, the southeast coastal areas of China were hit by Typhoon Lekima, which caused a large number of shallow landslides. The typhoon resulted in a maximum rainfall of 402 mm during 3 days in Ningguo City. In this study, satellite images were acquired before and after the rainfall and visual interpretation was used to identify 414 shallow landslides in Ningguo City, and a complete database of shallow landslides caused by the typhoon-induced rainfall in Ningguo City was created. Nine landslide-influencing factors were selected—elevation, slope, aspect, strata, distance to faults, distance to rivers, distance to roads, normalized vegetation difference index, and rainfall—and the relationships between the rainfall-induced landslide distribution and the influencing factors were analyzed. The Bayesian probability method was combined with a logistic regression model to establish a landslide probability map for the study area. The real probabilities of landslide occurrence in the study area under five different rainfall conditions were calculated, and probability maps of landslide occurrence were drawn. The results of this study provide a reference for disaster prevention and reduction of typhoon rainstorm landslides in the southeast coastal areas of China and a future basis for decision making by the Ningguo government departments before a typhoon rainstorm occurs.
Emotional State, Psychological Resilience, and Travel Intention to National Forest Park during COVID-19
Authors: Weng Lisheng , Wu Yawen , Han Guang , Liu Huifang , Cui Feng
Published: May 2022

The outbreak of the COVID-19 pandemic has impacted the tourism industry worldwide. This study examines the relationships among potential tourists’ emotional states, psychological resilience, and their travel intention to a national forest park in the context of COVID-19. It also investigates the moderating effect of gender. Kanas National Forest Park on the northwestern border of China was chosen as the research case. The survey questionnaires were administered both online and offline to collect data. A total of 492 valid questionnaires were collected (263 from online and 229 from offline) and analyzed in this study. Results demonstrate that visitors’ positive emotions have significant positive effects on their psychological resilience and travel intention. Yet, visitors’ negative emotions have significant negative effects on psychological resilience and travel intention. Moreover, psychological resilience partially mediates the relationship between emotional state and travel intention, indicating that visitors’ positive emotion and negative emotion can not only directly affect travel intention, but also indirectly affect travel intention through psychological resilience. The results of moderating effect analysis indicate that men and women are found to have differences in the experience of emotion, and women are more advised to foster positive emotions and psychological resilience. Visitors are advised to advocate more mutual encouragement, and tourism practitioners are recommended to provide tailored services to reduce travel anxiety. Findings provide implications on emotional regulation for tourists and crisis management strategies for nature-based tourism destinations.
Influence of Roller Configuration on the Fiber–Matrix Distribution and Mechanical Properties of Continuously Produced, Mineral-Impregnated Carbon Fibers (MCFs)
Authors: Liebscher Marco , Zhao Jitong , Wilms Gregor , Michel Albert , Wilhelm Kai , Mechtcherine Viktor
Published: May 2022

The article at hand is envisaged to enumerate significant technological parameters for the successful impregnation of carbon fiber rovings having 50,000 (50 K) filaments, each within a fine-grained, cementitious suspension. Parameters such as the number of rollers as well as the influence of roller deflection and rotation have been investigated and discussed with regard to the quality of the related impregnation and mechanical properties resulting therefrom. Morphological analysis disclosed distinct differences in the fiber matrix distribution, which are particularly reflected in the flexural performance of the mineral-impregnated carbon fibers (MCFs) produced. Moreover, with the best fiber matrix distribution, uniaxial tensile tests on MCFs demonstrated superior tensile strengths, moduli of elasticity, and elongations at rupture.
Mitral Valve Regurgitation Murmurs—Insights from Hemoacoustic Computational Modeling
Authors: Wang Ziyu , Seo Jung Hee , Mittal Rajat
Published: May 2022

Mitral regurgitation (MR) is the leakage of blood from the left ventricle into the left atrium during systole through a mitral valve that does not close fully. A systolic murmur is produced by MR and can be used to diagnose this disease. In the current study, we use hemoacoustic simulations to characterize the features of murmurs for a range of severities relevant to chronic MR. The incompressible Navier–Stokes equations are solved using an immersed boundary method to simulate the blood flow. The resultant pressure fluctuations on the lumen wall serve as the source for the murmur, and the murmur propagation through the thorax is modeled as a 3D elastic wave in a linear viscoelastic material. The resulting acceleration on the surface of the thorax is used as a surrogate for the measurement from a stethoscope, and these characteristics of the acceleration signal are examined in detail. We found that the intensity of the MR murmur is lower at the mitral point on the precordium, as compared with the aortic and pulmonic areas. This is somewhat counterintuitive but is supported by other studies in the past. We also found that the intensity of the murmur, as well as the break frequency, are well correlated with the severity of MR, and this information can be useful for automated auscultation and phonocardiographic applications.
Higher Yield and Polyphenol Content in Olive Pomace Extracts Using 2-Methyloxolane as Bio-Based Solvent
Authors: Cravotto Christian , Fabiano-Tixier Anne Sylvie , Claux Ombéline , Rapinel Vincent , Tomao Valérie , Stathopoulos Panagiotis , Skaltsounis Alexios Leandros , Tabasso Silvia , Jacques Laurence , Chemat Farid
Published: May 2022

Despite its severe toxicity and negative environmental impact, hexane remain the solvent of choice for the extraction of vegetable oils. This is in contrast with the constantly growing demand for sustainable and green extraction processes. In recent years a variety of alternatives to hexane have been reported, among them 2-methyloxolane (2-MeOx), which has emerged as a promising bio-based alternative. This study evaluates the possibility of replacing hexane, in the extraction of olive pomace (OP), with 2-MeOx, both dry and saturated with water (4.5%), the latter of which is called 2-MeOx 95.5%. The three solvents have been compared in terms of extraction yield and quality, as well as the lipid and polyphenol profiles of the extracts. The work concluded that both dry 2-MeOx and 2-MeOx 95.5% can replace hexane in OP extraction, resulting in higher yields and extracts richer in phenolic compounds. This study should open the road to further semi-industrial scale investigations toward more sustainable production processes.
By-Product Revalorization: Cava Lees Can Improve the Fermentation Process and Change the Volatile Profile of Bread
Authors: Martín-Garcia Alba , Riu-Aumatell Montserrat , López-Tamames Elvira
Published: May 2022

Wine lees are a by-product that represents a 25% of the total winery waste. Although lees are rich in antioxidant compounds and dietary fiber, they have no added value and are considered a residue. The aim of this study was to evaluate the effect of Cava lees (0 and 5% w/w) on microbial populations during sourdough and bread fermentation and the volatile fraction of the final bread. The results showed that 5% Cava lees promoted the growth of both lactic acid bacteria (LAB) and yeast in short fermentations (bread) but did not improve microbial growth in long fermentations (sourdough). Regarding volatile compounds, the addition of Cava lees increased the concentration of volatiles typically found in those products. Also, some compounds reported in sparkling wines were also identified in samples with Cava lees adsorbed on their surface. To sum up, the addition of Cava lees to sourdough and, especially, bread formulation may be a new strategy to revalorize such by-product.
Development and Validation of Benzophenone Derivatives in Packaged Cereal-Based Foods by Solid–Liquid Extraction and Ultrahigh-Performance Liquid Chromatography–Tandem Mass Spectrometry
Authors: Huang Yu-Fang , Huang Jun-Jie , Liu Xuan-Rui
Published: May 2022

We established and validated a sensitive multi-residue analytical method for identifying benzophenone (BP) and nine BP derivatives (2,4-dihydroxybenzophenone [BP-1], 2,2′,4,4′-tetrahydroxydroxybenzophenone, 2-hydroxy-4-methoxy benzophenone, 2,2′-dihydroxy 4-methoxy benzophenone, 2-hydroxybenzophenone [2-OHBP], 4-hydroxybenzophenone, 4-methylbenzophenone [4-MBP], methyl-2-benzoylbenzoate, and 4-benzoylbiphenyl). Solid–liquid extraction pretreatment and ultra-high-performance liquid chromatography–tandem mass spectrometry (UHPLC–MS/MS) were employed in an analysis of 85 packaged cereal-based food samples (25 pastry, 50 rice, and 10 noodle samples). The method had satisfactory linearity (R2 ≥ 0.995), low limits of detection (pastry: 0.02–4.2 ng/g; rice and noodle: 0.02–2 ng/g), and favorable precision, with within-run and between-run coefficient of variation ranges of 1–29% and 1–28%, respectively. BP and 4-MBP were detected in 100% of the pastry samples, and BP-1 and 2-OHBP were found in 76% and 56% of the pastry samples, respectively. BP and 2-OHBP were found in 92% and 38% of the rice samples, respectively. BP was found in 50% of the noodle samples. BP contributed the most to the total level of BPs in pastries, with significantly higher mean ± standard deviation (range) levels for pastries (26.8 ± 32.6 [1.8–115.4] ng/g) than rice (1.2 ± 2.0 [0.4–13.4] ng/g) and noodles (0.7 ± 0.7 [0.4–1.9] ng/g); p < 0.0001). The trace levels of 4-MBP identified in the samples demonstrate the need for the development of analytical methods with high sensitivity and specificity; the proposed method satisfies this need.
Effects of Drying Methods and Temperatures on the Quality of Chestnut Flours
Authors: Conti Veronica , Salusti Patrizia , Romi Marco , Cantini Claudio
Published: May 2022

The demand for chestnut flour is growing because of its use in gluten-free products. Previous studies have correlated the quality of chestnut flours to the drying temperature and technology applied. This work is a novel study on the role of the traditional drying method with a wood fire in a “metato” building for flour compared with a food dryer at 40 °C or 70 °C. The contents of antioxidants, total polyphenols and sugars were determined as well as the presence of toxic volatiles or aflatoxins. The flour, resulting from the traditional method, presented lower polyphenol content and antioxidant power compared to the others. The content of the sugars was similar to the flours obtained after drying with hot air, both at 40 °C and 70 °C. The toxic volatile molecules, furfural, guaiacol, and o-cresol, were found. There was no correlation between the aflatoxin content and the presence of damage in chestnut fruits. The traditional method should not be abandoned since it confers a pleasant smoky taste to the product, but it is necessary to regulate the level and steadiness of temperature. Future research needs to be directed to the quantification of harmful volatile compounds and their correlation with the quantity of smoke emitted by the wood fire.
Assessing Acerola Powder as Substitute for Ascorbic Acid as a Bread Improver
Authors: Franco Maria , Belorio Mayara , Gómez Manuel
Published: May 2022

Bread is one of the most widely consumed products in the world. The use of oxidants is common in bread production, but consumers are demanding products with less additives. Acerola is the fruit with the highest ascorbic acid content and, once dried, it can be used as an oxidant in baking. The use of acerola powder in bread making and its effect on bread quality is studied in this article and compared with the addition of ascorbic acid. For this purpose, flour properties and dough behaviour were analysed with a farinograph and an alveograph. Breads were elaborated with white wheat flour and wholemeal flour; specific volume, loaf height, weight loss, texture, colour, and cell structure were analysed. Acerola powder had similar effects to ascorbic acid: it increased the alveographic strength and the tenacity of the doughs without reducing extensibility; it incremented dough development time (DDT) and dough softening; it increased the specific volume of white wheat breads, and it reduced the hardness of white and wholemeal breads, without significant changes in crust or crumb colour. Therefore, acerola powder can be a natural alternative to the use of ascorbic acid as an improver in bread making.
An Averaging Principle for Stochastic Fractional Differential Equations Driven by fBm Involving Impulses
Authors: Liu Jiankang , Wei Wei , Xu Wei
Published: May 2022

In contrast to previous research on periodic averaging principles for various types of impulsive stochastic differential equations (ISDEs), we establish an averaging principle without periodic assumptions of coefficients and impulses for impulsive stochastic fractional differential equations (ISFDEs) excited by fractional Brownian motion (fBm). Under appropriate conditions, we demonstrate that the mild solution of the original equation is approximately equivalent to that of the reduced averaged equation without impulses. The obtained convergence result guarantees that one can study the complex system through the simplified system. Better yet, our techniques dealing with multi-time scales and impulsive terms can be applied to improve some existing results. As for application, three examples are worked out to explain the procedure and validity of the proposed averaging principles.
Stability Analysis for a Fractional-Order Coupled FitzHugh–Nagumo-Type Neuronal Model
Authors: Brandibur Oana , Kaslik Eva
Published: May 2022

The aim of this work is to describe the dynamics of a fractional-order coupled FitzHugh–Nagumo neuronal model. The equilibrium states are analyzed in terms of their stability properties, both dependently and independently of the fractional orders of the Caputo derivatives, based on recently established theoretical results. Numerical simulations are shown to clarify and exemplify the theoretical results.
Novel Approaches for Differentiable Convex Functions via the Proportional Caputo-Hybrid Operators
Authors: Gürbüz Mustafa , Akdemir Ahmet Ocak , Dokuyucu Mustafa Ali
Published: May 2022

This study is built on the relationship between inequality theory and fractional analysis. Thanks to the new fractional operators and based on the proportional Caputo-hybrid operators, integral inequalities containing new approaches are obtained for differentiable convex functions. In the findings section, firstly, an integral identity is obtained and various integral inequalities are obtained based on this identity. The peculiarity of the results is that a hybrid operator has been used in inequality theory, which includes the derivative and integral operators together.
A New Parallelized Computation Method of HASC-N Difference Scheme for Inhomogeneous Time Fractional Fisher Equation
Authors: Liu Ren , Yang Xiaozhong , Lyu Peng
Published: May 2022

The fractional Fisher equation has a wide range of applications in many engineering fields. The rapid numerical methods for fractional Fisher equation have momentous scientific meaning and engineering applied value. A parallelized computation method for inhomogeneous time-fractional Fisher equation (TFFE) is proposed. The main idea is to construct the hybrid alternating segment Crank-Nicolson (HASC-N) difference scheme based on alternating segment difference technology, using the classical explicit scheme and classical implicit scheme combined with Crank-Nicolson (C-N) scheme. The unique existence, unconditional stability and convergence are proved theoretically. Numerical tests show that the HASC-N difference scheme is unconditionally stable. The HASC-N difference scheme converges to O(τ2−α+h2) under strong regularity and O(τα+h2) under weak regularity of fractional derivative discontinuity. The HASC-N difference scheme has high precision and distinct parallel computing characteristics, which is efficient for solving inhomogeneous TFFE.
Asymmetric Lévy Flights Are More Efficient in Random Search
Authors: Padash Amin , Sandev Trifce , Kantz Holger , Metzler Ralf , Chechkin Aleksei V.
Published: May 2022

We study the first-arrival (first-hitting) dynamics and efficiency of a one-dimensional random search model performing asymmetric Lévy flights by leveraging the Fokker–Planck equation with a δ-sink and an asymmetric space-fractional derivative operator with stable index α and asymmetry (skewness) parameter β. We find exact analytical results for the probability density of first-arrival times and the search efficiency, and we analyse their behaviour within the limits of short and long times. We find that when the starting point of the searcher is to the right of the target, random search by Brownian motion is more efficient than Lévy flights with β≤0 (with a rightward bias) for short initial distances, while for β>0 (with a leftward bias) Lévy flights with α→1 are more efficient. When increasing the initial distance of the searcher to the target, Lévy flight search (except for α=1 with β=0) is more efficient than the Brownian search. Moreover, the asymmetry in jumps leads to essentially higher efficiency of the Lévy search compared to symmetric Lévy flights at both short and long distances, and the effect is more pronounced for stable indices α close to unity.
Asymmetric Horizontal Differentiation under Advertising in a Cournot Duopoly
Authors: Brady Malcolm
Published: May 2022

Horizontal differentiation is generally derived from the aggregate utility function and is assumed to be symmetric. However, empirical work suggests that asymmetric horizontal differentiation can exist in practice. This paper examines the topic of asymmetric horizontal differentiation by allowing a firm’s costly advertising to have a different impact on its own demand function than it does on that of its rival. This leads to the interesting analytical result that advertising that increases the cross-price effect of its rival can lead to an increase in firm profits. This introduces the possibility of a ‘couple’ effect where firm advertising can tilt its own and its rival’s demand functions in different directions. Several competitive advertising ‘couple’ scenarios are explored using numerical simulation.
When Welfare State “Integration” Becomes an Intimate Family Affair: Ethnic Minority Parents’ Everyday Orchestration of Their Children’s Future Belonging in Denmark
Authors: Larsen Birgitte Romme
Published: May 2022

Based on a qualitative interview study, this article focuses on the everyday organization of family life in Denmark among ethnic minority parents with Pakistani, Turkish, Palestinian and Iraqi backgrounds, with a particular view to the quotidian resource management of time and money within intimate parent–child relationships. Through this focus on how the parents prioritize their everyday time and financial resources from an intergenerational perspective, the article explores the motivations and reasoning behind such arrangements of family life—including how they reflect parents’ visions for their children’s future lives. While it applies a time-use and consumption perspective to examine mundane family lives, as opposed to, for instance, a social integration perspective, the analysis nonetheless reveals how Danish policy and public debate on the “integration” of ethnic minorities directly and in detail shapes the quotidian orchestration of family life and its intimate relations. This translates into a highly concrete, everyday concern with and attentiveness towards “integration” among the parents. This attentiveness towards the Danish integration debate haunts the parents’ sense of self. Moreover, I argue that it materializes in routinized family life practices, strongly shaping the innermost private sphere of mundane parental choices regarding the day-to-day management of time and money, and in the everyday strategies for the next generation’s future belonging in Denmark expressed in this management.
Efficient Simultaneous Introduction of Premature Stop Codons in Three Tumor Suppressor Genes in PFFs via a Cytosine Base Editor
Authors: Jiang Haoyun , Jing Qiqi , Yang Qiang , Qiao Chuanmin , Liao Yaya , Liu Weiwei , Xing Yuyun
Published: May 2022

Base editing is an efficient and precise gene-editing technique, by which a single base can be changed without introducing double-strand breaks, and it is currently widely used in studies of various species. In this study, we used hA3A-BE3-Y130F to simultaneously introduce premature stop codons (TAG, TGA, and TAA) into three tumor suppressor genes, TP53, PTEN, and APC, in large white porcine fetal fibroblasts (PFFs). Among the isolated 290 single-cell colonies, 232 (80%) had premature stop codons in all the three genes. C−to−T conversion was found in 98.6%, 92.8%, and 87.2% of these cell colonies for TP53, PTEN, and APC, respectively. High frequencies of bystander C−to−T edits were observed within the editing window (positions 3–8), and there were nine (3.01%) clones with the designed simultaneous three-gene C−to−T conversion without bystander conversion. C−to−T conversion outside the editing window was found in 9.0%, 14.1%, and 26.2% of the 290 cell colonies for TP53, PTEN, and APC, respectively. Low-frequency C−to−G or C−to−A transversion occurred in APC. The mRNA levels of the three genes showed significant declines in triple-gene-mutant (Tri-Mut) cells as expected. No PTEN and a significantly lower (p < 0.05) APC protein expression were detected in Tri-Mut cells. Interestingly, the premature stop codon introduced into the TP53 gene did not eliminate the expression of its full-length protein in the Tri-Mut cells, suggesting that stop codon read-through occurred. Tri-Mut cells showed a significantly higher (p < 0.05) proliferation rate than WT cells. Furthermore, we identified 1418 differentially expressed genes (DEGs) between the Tri-Mut and WT groups, which were mainly involved in functions such as tumor progression, cell cycle, and DNA repair. This study indicates that hA3A-BE3-Y130F can be a powerful tool to create diverse knockout cell models without double-strand breaks (DSBs), with further possibilities to produce porcine models with various purposes.
Feature Fusion and Detection in Alzheimer’s Disease Using a Novel Genetic Multi-Kernel SVM Based on MRI Imaging and Gene Data
Authors: Meng Xianglian , Wei Qingpeng , Meng Li , Liu Junlong , Wu Yue , Liu Wenjie
Published: May 2022

Voxel-based morphometry provides an opportunity to study Alzheimer’s disease (AD) at a subtle level. Therefore, identifying the important brain voxels that can classify AD, early mild cognitive impairment (EMCI) and healthy control (HC) and studying the role of these voxels in AD will be crucial to improve our understanding of the neurobiological mechanism of AD. Combining magnetic resonance imaging (MRI) imaging and gene information, we proposed a novel feature construction method and a novel genetic multi-kernel support vector machine (SVM) method to mine important features for AD detection. Specifically, to amplify the differences among AD, EMCI and HC groups, we used the eigenvalues of the top 24 Single Nucleotide Polymorphisms (SNPs) in a p-value matrix of 24 genes associated with AD for feature construction. Furthermore, a genetic multi-kernel SVM was established with the resulting features. The genetic algorithm was used to detect the optimal weights of 3 kernels and the multi-kernel SVM was used after training to explore the significant features. By analyzing the significance of the features, we identified some brain regions affected by AD, such as the right superior frontal gyrus, right inferior temporal gyrus and right superior temporal gyrus. The findings proved the good performance and generalization of the proposed model. Particularly, significant susceptibility genes associated with AD were identified, such as CSMD1, RBFOX1, PTPRD, CDH13 and WWOX. Some significant pathways were further explored, such as the calcium signaling pathway (corrected p-value = 1.35 × 10−6) and cell adhesion molecules (corrected p-value = 5.44 × 10−4). The findings offer new candidate abnormal brain features and demonstrate the contribution of these features to AD.
Correlation of NTRK1 Downregulation with Low Levels of Tumor-Infiltrating Immune Cells and Poor Prognosis of Prostate Cancer Revealed by Gene Network Analysis
Authors: Bagherabadi Arash , Hooshmand Amirreza , Shekari Nooshin , Singh Prithvi , Zolghadri Samaneh , Stanek Agata , Dohare Ravins
Published: May 2022

Prostate cancer (PCa) is a life-threatening heterogeneous malignancy of the urinary tract. Due to the incidence of prostate cancer and the crucial need to elucidate its molecular mechanisms, we searched for possible prognosis impactful genes in PCa using bioinformatics analysis. A script in R language was used for the identification of Differentially Expressed Genes (DEGs) from the GSE69223 dataset. The gene ontology (GO) of the DEGs and the Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analysis were performed. A protein–protein interaction (PPI) network was constructed using the STRING online database to identify hub genes. GEPIA and UALCAN databases were utilized for survival analysis and expression validation, and 990 DEGs (316 upregulated and 674 downregulated) were identified. The GO analysis was enriched mainly in the “collagen-containing extracellular matrix”, and the KEGG pathway analysis was enriched mainly in “focal adhesion”. The downregulation of neurotrophic receptor tyrosine kinase 1 (NTRK1) was associated with a poor prognosis of PCa and had a significant positive correlation with infiltrating levels of immune cells. We acquired a collection of pathways related to primary PCa, and our findings invite the further exploration of NTRK1 as a biomarker for early diagnosis and prognosis, and as a future potential molecular therapeutic target for PCa.
Whole-Genome Sequencing Reveals Lignin-Degrading Capacity of a Ligninolytic Bacterium (Bacillus cereus) from Buffalo (Bubalus bubalis) Rumen
Authors: Zhong Huimin , Zhou Jiayan , Wang Fan , Wu Wenqing , Abdelrahman Mohamed , Li Xiang
Published: May 2022

The buffalo is an amazing ruminant. Its ability to degrade lignin, which has been recently reported, is most likely due to unique rumen microorganisms with lignin-degradation potential. Our goal was to explore the lignin-degradation potential of ruminal microorganisms, in which ligninolytic enzyme encoding genes were involved to provide ideas for revealing the mechanism of lignin degradation by buffalo. In this study, a bacterium strain identified as Bacillus cereus AH7-7 was isolated from the buffalo (Bubalus bubalis) rumen. After whole-genome sequencing, the results demonstrated that B. cereus AH7-7 had laccase, cytochrome P450 and vanillin alcohol oxidase-encoding genes. Sixty-four genes of B. cereus AH7-7 were involved in multiple aromatic metabolic pathways, such as phenylalanine metabolism and aminobenzoate degradation. A positive reaction resulting in guaiacol medium indicated that laccase secretion from B. cereus AH7-7 increased with time. A biodegradation experiment revealed that a significant reduction in kraft lignin content (25.9%) by B. cereus AH7-7 occurred at the end of 6 days of incubation, which confirmed its lignin-degradation capacity. Overall, this is the first report showing that B. cereus AH7-7 from the buffalo rumen can degrade lignin, and revealing the encoding genes of lignin-degrading enzymes from genome level.
The Molecular Genetics of Dissociative Symptomatology: A Transdiagnostic Literature Review
Authors: Rajkumar Ravi Philip
Published: May 2022

Dissociative disorders are a common and frequently undiagnosed group of psychiatric disorders, characterized by disruptions in the normal integration of awareness, personality, emotion and behavior. The available evidence suggests that these disorders arise from an interaction between genetic vulnerability and stress, particularly traumatic stress, but the attention paid to the underlying genetic diatheses has been sparse. In this paper, the existing literature on the molecular genetics of dissociative disorders, as well as of clinically significant dissociative symptoms not reaching the threshold of a disorder, is reviewed comprehensively across clinical and non-clinical samples. Association studies suggest a link between dissociative symptoms and genes related to serotonergic, dopaminergic and peptidergic transmission, neural plasticity and cortisol receptor sensitivity, particularly following exposure to childhood trauma. Genome-wide association studies have identified loci of interest related to second messenger signaling and synaptic integration. Though these findings are inconsistent, they suggest biologically plausible mechanisms through which traumatic stress can lead to pathological dissociation. However, methodological concerns related to phenotype definition, study power, and correction for the confounding factors limit the value of these findings, and they require replication and extension in studies with better design.