bluuebunny/crossref_metadata_2025 huggingface dataset:
Gas Content and Geological Control of Deep Jurassic Coalbed Methane in Baijiahai Uplift, Junggar Basin
Authors: Luo Bing , Wang Haichao , Sun Bin , Ouyang Zheyuan , Yang Mengmeng , Wang Yan , Zhou Xiang
Published: November 2024

Deep coalbed methane (CBM) resources are abundant in China, and in the last few years, the country’s search for and extraction of CBM have intensified, progressively moving from shallow to deep strata and from high-rank coal to medium- and low-rank coal. On the other hand, little is known about the gas content features of deep coal reservoirs in the eastern Junggar Basin, especially with regard to the gas content and the factors that affect it. Based on data from CBM drilling, logging, and seismic surveys, this study focuses on the gas content of Baijiahai Uplift’s primary Jurassic coal seams through experiments on the microscopic components of coal, industrial analysis, isothermal adsorption, low-temperature CO2, low-temperature N2, and high-pressure mercury injection. A systematic investigation of the controlling factors, including the depth, thickness, and quality of the coal seam and pore structure; tectonics; and lithology and thickness of the roof, was conducted. The results indicate that the Xishanyao Formation in the Baijiahai Uplift usually has a larger gas content than that in the Badaowan Formation, with the Xishanyao Formation showing that free gas and adsorbed gas coexist, while the Badaowan Formation primarily consists of adsorbed gas. The coal seams in the Baijiahai Uplift are generally deep and thick, and the coal samples from the Xishanyao and Badawan formations have a high vitrinite content, which contributes to their strong gas generation capacity. Additionally, low moisture and ash contents enhance the adsorption capacity of the coal seams, facilitating the storage of CBM. The pore-specific surface area of the coal samples is primarily provided by micropores, which is beneficial for CBM adsorption. Furthermore, a fault connecting the Carboniferous and Permian systems (C-P) developed in the northeastern part of the Baijiahai Uplift allows gas to migrate into the Xishanyao and Badaowan formations, resulting in a higher gas content in the coal seams. The roof lithology is predominantly mudstone with significant thickness, effectively reducing the dissipation of coalbed methane and promoting its accumulation.
Development of a Niobium-Based Coordination Compound with Catalytic Applications for Green Hydrogen Evolution
Authors: Squizzatto Emily Pacheco , Andrade Tatianny de Araujo , Lopes Moreira Renata Pereira , Guimarães Luciano de Moura , da Silva Márcio José , Novaes Fábio Junior Moreira , de Jesus Jemmyson Romário
Published: November 2024

Green hydrogen (H2) offers a sustainable alternative to non-renewable energy sources. This study focuses on enhancing H2 generation from sodium borohydride (NaBH4) using a platinum nanoparticle (Pt-NP) catalyst supported on a niobium-based coordination compound, [Nb(BDC)0.9(PDC)0.1]n, synthesized via a solvothermal method with 1,4-benzenedicarboxylic acid (BDC) and 2,5-pyridinedicarboxylic acid (PDC). Characterization techniques including Scanning Electron Microscopy (SEM), Energy Dispersive X-ray Spectroscopy (EDS), Brunauer–Emmett–Teller (BET) analysis, Raman spectroscopy, and X-ray diffraction (XRD) confirm the morphology, composition, surface area (398.583 m2g−1), and crystallinity of the material. The in situ synthesized Pt-NPs showed a hydrogen generation rate (HGR) of 86.588 mL min−1 g−1 when alone, while the supported catalyst achieved an enhanced HGR of 119.020 mL min−1 g−1 under optimal conditions (10 mmol% Pt, 0.5 mmol NaBH4, 303.15 K). The low activation energy (Ea) of 16.38 kJ mol−1 indicates efficient catalysis. The catalyst maintained stable performance in recycling tests, demonstrating its potential for practical applications in H2 evolution from NaBH4.
Open Science Alternatives to Scopus and the Web of Science: A Case Study in Regional Resilience
Authors: Turgel Irina D. , Chernova Olga A.
Published: November 2024

The recent years have seen increasing support for open science in academic circles. However, the large number of scientometric databases calls into question the comparability of the search and analysis tools they provide. Using the subject area of regional resilience as an example, in this study, the aim was to analyze the capabilities of widely used databases to serve as alternatives to Scopus and Web of Science in solving research problems. As alternatives, in the present article, the following open, free scientometric databases were considered: AMiner, Wizdom.ai, the Lens, Dimensions, and OpenAlex. Their capabilities were demonstrated for the subject area under study, and the obtained results were compared. The study results showed that alternative databases provide essential data on trends in scientific development. It is noteworthy that they largely replicate the provided data, supplementing and expanding them by using different types of data sources. However, open databases do not guarantee a high quality of materials and exhibit a relatively low level of metadata. Thus, it is premature to abandon the use of Scopus and Web of Science in research activities. Since scientometric databases were developed in different contexts, they are characterized by structural and functional heterogeneity, which complicates their comparison. Therefore, a selective approach should be adopted for the choice of scientometric databases, taking into account financial and other constraints, as well as the specifics of research problems.
Social Movements, Social Change, and International Cooperation: Strategic Insights from Latin America and the Caribbean
Authors: Ayres Cássia , Vega-Casanova Jair , Arroyave Cabrera Jesús
Published: November 2024

In the wake of the advancements made in civil and human rights in the twentieth century, social movements have come to be regarded as a driving force behind social change. Nevertheless, evidence demonstrates that social transformations driven by certain citizen mobilisations do not always prove beneficial to the most marginalised groups. In January 2023, acts of vandalism were perpetrated against the buildings of public institutions in Brasilia. Similarly, anti-democratic mobilisations have been observed in Colombia against the peace agreement with the FARC and in Chile against the proposed more inclusive constitution. Globally, anti-democracy and other movements that are in opposition to human rights are gaining ground, and their effects are having a detrimental impact on the environment in which organisations that are advocating for excluded sectors are operating. However, Latin American perspectives of social and behaviour change (SBC) emphasise engagement with social movements to contribute to social justice, creating alliances to amplify the voices of those most affected without interfering with the organic nature of citizen-led movements. This prompts the following inquiries: Can we categorize as social movements those with popular roots but espousing hegemonic interests? How can the Latin American tradition of social movement action and reflection inform strategies for social change? How can SBC strategies counteract anti-human rights movements and empower social movements prone to inclusion? This essay addresses these questions.
Generational Identity, Values, and Sense of Belonging
Authors: Barsallo Gabisel , Ortiz Víctor , Yanis-Orobio Rebeca , Mendoza Elisa
Published: November 2024

In Panama, “Generation Y” was identified at the beginning of this millennium, which was two decades after the first reports of such a generation. However, the overall evolution caused by globalization and digital development generated changes at the collective level in society, as is to be expected. This article aims to provide a look at how Panamanians identified as Generation Y or Millennials express their national identity, values, and sense of belonging. This article presents a descriptive approach performed on the responses to a national survey of a sample of 384 people considered Millennials for the project “Panama’s millennials: sense of belonging and national identity in a globalized society”. The main findings show that this generation is very much in favor of equal rights between men, women, immigrants, and disabled persons; they advocate pro-social issues but show differences regarding the protection of the future. The majority of them disagree with civil society organizations, do not identify with the health system, nor do they recognize quality in the education system or state-sponsored employment-generating activities. They also highlighted imbalances in the implementation of justice and the distribution of the country’s wealth.
The Acute Effect of Different Cluster Set Intra-Set Rest Interval Configurations on Mechanical Power Measures During a Flywheel Resistance Training Session
Authors: Ryan Shane , Browne Declan , Ramirez-Campillo Rodrigo , Moody Jeremy , Byrne Paul J.
Published: November 2024

The aim of this study was to compare the acute effect of three cluster set (CS) intra-set rest intervals (15 s, 30 s, and 45 s) on mechanical performance measures during a flywheel resistance training session. Twelve amateur male field sport athletes attended three training measurement sessions (separated by 14 days of wash-out), consisting of four sets of nine repetitions (as cluster-blocks: 3 + 3 + 3), using a 0.050 kg·m−2 inertial load. The flywheel quarter-squat (QS) and the flywheel Romanian deadlift (RDL) were selected as resistance training exercises. Participants were randomly allocated different CS intra-set rest durations: 15 s, 30 s, or 45 s. The mean power (MP), peak concentric power (PPcon), peak eccentric power (PPecc), and eccentric overload (EO) were measured. A two-way (within–within) repeated-measures ANOVA reported that MP, PPcon, PPecc, and EO achieved similar values during the QS and RDL sessions involving 30 s and 45 s CS intra-set rest durations. It was noted that the first set did not always result in the greatest performance output for the 30 s and 45 s intervals. Compared to 15 s, the 30 s and 45 s CS intra-set rest durations showed greater MP, PPcon, and PPecc during set 2 (all p ≤ 0.05), set 3 (all p < 0.001), and set 4 (all p < 0.001) for both QS and RDL, and greater EO in the QS exercise (the four sets combined). Compared to shorter (15 s) cluster set intra-set rest intervals, longer (30–45 s) configurations allow greater physical performance outcome measures during flywheel QS and RDL resistance training sessions. The implications for longer-term interventions merit further research.
Effects of Lane Imbalance on Capacity Drop and Emission in Expressway Merging Areas: A Simulation Analysis
Authors: Zhang Kai , Rong Jian , Gao Yacong , Chen Yue
Published: November 2024

Lane imbalance does not provide sufficient space for merging vehicles to adjust their speed and change lanes smoothly. This leads to improper driving behavior that disrupts mainline traffic flow stability, resulting in capacity drops and increased vehicle emissions. However, quantitative analyses, specifically the effects of lane imbalance on capacity and emissions, remain limited. Existing traffic simulation platforms struggle to capture the effects of geometric design changes on capacity. To address these gaps, we developed a simulation method incorporating interactions between geometric design and traffic flow demand into an XGBoost model, enhancing the predictive accuracy for driving behavior parameters. Implemented within the TESS NG platform, this model enables real-time adjustments in driving behavior parameters as traffic demand varies under different lane balance conditions. The simulation results indicated a 42.4% capacity drop and a 34.9% increase in CO2 emissions when the balanced merging area was shifted to lane imbalance. Conversely, shifting to lane balance increases capacity by 8.2% and reduces CO2 emissions by 39.8% under severe congestion conditions. Under lane imbalance, vehicle speeds are lower across all traffic demand levels. When the demand exceeds 1300 pcu/h/ln, lane changes occur closer to the end of the acceleration lane, with higher speed differentials. These insights underscore the potential of lane balance optimization to mitigate capacity drops and emissions, providing a valuable simulation approach for the design and evaluation of merging areas.
Development of a Forecasting Framework Based on Advanced Machine Learning Algorithms for Greenhouse Gas Emissions
Authors: Ene Yalçın Seval
Published: November 2024

The reduction of greenhouse gas emissions, in order to effectively address the issue of climate change, has critical importance worldwide. To achieve this aim and implement the necessary strategies and policies, the projection of greenhouse gas emissions is essential. This paper presents a forecasting framework for greenhouse gas emissions based on advanced machine learning algorithms: multivariable linear regression, random forest, k-nearest neighbor, extreme gradient boosting, support vector, and multilayer perceptron regression algorithms. The algorithms employ several input variables associated with greenhouse gas emission outputs. In order to evaluate the applicability and performance of the developed framework, nationwide statistical data from Turkey are employed as a case study. The dataset of the case study includes six input variables and annual sectoral and total greenhouse gas emissions in CO2 eq. as output variables. This paper provides a scenario-based approach for future forecasts of greenhouse gas emissions and a sector-based analysis of greenhouse gas emissions in the case country considering multiple input variables. The present study indicates that the stated machine learning algorithms can be successfully applied to the forecasting of greenhouse gas emissions.
Resource Sizing for Virtual Environments of Networked Interconnected System Services
Authors: Albychev Alexandr , Ilin Dmitry , Nikulchev Evgeny
Published: November 2024

Networked interconnected systems are often deployed in infrastructures with resource allocation using isolated virtual environments. The technological implementation of such systems varies significantly, making it difficult to accurately estimate the required volume of resources to allocate for each virtual environment. This leads to overprovisioning of some services and underprovisioning of others. The problem of distributing the available computational resources between the system services arises. To efficiently use resources and reduce resource waste, the problem of minimizing free resources under conditions of unknown ratios of resource distribution between services is formalized; an approach to determining regression dependencies of computing resource consumption by services on the number of requests and a procedure for efficient resource distribution between services are proposed. The proposed solution is experimentally evaluated using the networked interconnected system model. The results show an increase in throughput by 20.75% compared to arbitrary resource distribution and a reduction in wasted resources by 55.59%. The dependences of the use of resources by networked interconnected system services on the number of incoming requests, identified using the proposed solution, can also be used for scaling in the event of an increase in the total volume of allocated resources.
Isolated High-Gain DC-DC Converter with Nanocrystalline-Core Transformer: Achieving 1:16 Voltage Boost for Renewable Energy Applications
Authors: Sandoval-Valencia Tania , Ruiz-Robles Dante , Ortíz-Marín Jorge , Franco Jesus Alejandro , Hernandez-Escobedo Quetzalcoatl , Moreno-Goytia Edgar
Published: November 2024

This paper presents an isolated DC-DC converter with high voltage gain that features an advanced inter-built nanocrystalline-core medium-frequency transformer (NC-MFT). The isolated DC-DC converter with an NC-MFT is specifically designed for applications such as interconnect photovoltaic (PV) systems, DC microgrids, DC loads, and DC buses, where voltage gain is one of the essential issues to consider. The NC-MFT inside the DC-DC converter is designed with a new approach that not only provides isolation but also contributes to achieving high efficiency and a higher step-up ratio. The high efficiency of the converters contributes to the integration of PV systems into DC microgrids. The converter yields a high voltage conversion ratio of 16.17. The experimental results obtained at 41.8 V/676 V and 275 W for the prototype revealed high efficiency (95.63% at full load). The experimental results validate the theoretical analysis and simulation, confirming that the converter achieves the main objective of high voltage conversion and high efficiency. These results will contribute to the interest in the use of this type of energy and its impact on the reduction in CO2 emissions.
Leveraging Data from a Provincial Electronic Immunization Registry to Analyze Immunization Coverage, Timeliness, and Defaulters Among 8.8 Million Children from the 2018 to 2023 Birth Cohorts in Sindh Province, Pakistan
Authors: Miraj Fatima , Iftikhar Sundus , Siddique Muhammad , Dharma Vijay Kumar , Shah Mubarak Taighoon , Siddiqi Danya Arif , Chandir Subhash
Published: November 2024

Background/Objectives: Full immunization coverage in Pakistan remains suboptimal at 66%. An in-depth assessment is needed to understand the long-term trends in immunization and identify the extent of defaulters and associated risk factors of them being left uncovered by the immunization system. Methods: We conducted a 5-year analysis using the Government’s Provincial Electronic Immunization Registry data for the 2018–2023 birth cohorts in Sindh province. We analyzed 8,792,392 child-level immunization records from 1 January 2018 to 31 May 2024 to examine trends in immunization coverage, timeliness, defaulter rates, and associated risk factors; Results: Our findings indicate gradual improvements in immunization coverage, with full immunization rates increasing by 23.2% (from 47.5% to 70.7%) from 2018 to 2022. While timeliness declined from 2018 to 2021, it recovered in 2022 and 2023. Over the 5-year study period, >90% of children defaulted on vaccinations, with 34.8% fully covered and 9.1% uncovered. Children from urban areas (OR = 1.54; 95% CI = 1.52, 1.56; p-value < 0.001) and those enrolled through fixed immunization sites (OR = 2.11; 95% CI = 2.08, 2.15; p-value < 0.001) and mobile immunization vans (OR = 1.13; 95% CI = 1.13, 1.77; p-value = 0.003) were at higher risk of being uncovered defaulters. Conclusions: This study demonstrates improvements in immunization coverage in Sindh while highlighting the challenge of low timeliness and high default rates. Our findings provide insights to strengthen immunization access and timeliness, particularly in high-default areas, and can guide policies in similar low-income settings for more equitable and comprehensive immunization coverage.
Vaccine Efficacy and Safety in Patients with Celiac Disease
Authors: Scarmozzino Rocco , Zanoni Giovanna , Arcolaci Alessandra , Ciccocioppo Rachele
Published: November 2024

Celiac disease (CD) is an autoimmune disorder caused by gluten intake in genetically predisposed individuals. This article provides an overview of the available data on the risks of infectious diseases and the mechanisms involved in CD, including a detailed analysis of vaccine efficacy, immunogenicity, and safety. The published articles were retrieved from the PubMed database using the terms “celiac disease”, “efficacy”, “hyposplenism”, “immune response”, “infections”, “immunization”, “immunogenicity”, “safety”, “vaccination”, and “vaccine”. CD can be associated with several autoimmune diseases, including selective immunoglobulin A deficiency (SIgAD), altered mucosal permeability, and hyposplenism. These conditions entail an increased risk of infections, which can be prevented by targeted vaccinations, although specific recommendations on immunization practices for subjects with CD have not been released. Regarding vaccinations, the immune response to the Hepatitis B virus (HBV) vaccine can be impaired in patients with CD; therefore, proposed strategies to elicit and maintain protective specific antibody titers are summarized. For patients with conditions that put them at risk of infections, vaccinations against Pneumococcus and other encapsulated bacteria should be recommended. Based on the available evidence, the Rotavirus vaccine offered to children could be useful in preventing CD in at-risk subjects. Overall, except for the HBV vaccine, vaccine efficacy in patients with CD is comparable to that in the general population, and no safety concerns have arisen.
Erzincan İliç Altın Madeni: Politik Ekoloji Perspektifinden Bir Facianın Anatomisi
Authors: Canbaz Akça Kübra
Published: November 2024

Madencilik faaliyetleri doğru planlamalar ve yönetimler çerçevesinde sürdürüldüğünde güçlü bir kalkınma aracı olarak değerlendirilebilir. Ancak madencilik faaliyetlerinin doğrudan insan ve çevreyle olan bağı düşünüldüğünde doğru ilke ve kurallar gözetilmediğinde önemli sorunlara da yol açabileceği göz önünde bulundurulmalıdır. Doğru politikalarla sürdürülemeyen her madencilik faaliyeti ekonomik büyümeyi desteklese de ekolojik dengenin bozulmasına sebep olmaktadır. Bu sebeple bu alandaki faaliyetlerin politikalarla güçlendirilmesi, insana ve doğaya olan yansımasının göz önünde bulundurulması ve ekonomik anlamda sağlanacak olan getirinin ekoloji göz önünde bulundurularak sürdürülmesi gerekmektedir. Bu çalışmada madencilik faaliyetlerinin ekonomik, politik ve ekolojik kapsamda değerlendirilmesi Erzincan/ İliç altın madeni olayı özelinde gerçekleştirilmiştir. 2024 yılı şubat ayında gerçekleşen toprak kayması öncesinde ve sonrasında var olan ekonomik etkileri, politik süreçleri ve ekolojik yansımalarının çerçevesi çizilmeye çalışılmıştır. Çalışmada Doküman Analizi Yöntemi kullanılmıştır. Çalışma sonucunda Erzincan/İliç altın madeninin ülkemiz ekonomisinde önemli bir yeri olduğu tespit edilmiştir. Bununla birlikte altın madeninde yaşanan kazanın ekolojik açıdan büyük bir tehlike barındırdığı ve ihmallerin büyük oranda ortam hazırladığı edinilen bulgular arasındadır.
The role of reader literacy in ensuring the global competitiveness of Russian education
Authors:   MBOU «Secondary School No. 49» in Kursk, Chernykh Tatyana Igorevna
Published: November 2024

This article examines the role of reader literacy in ensuring the global competitiveness
of Russian education at the present stage. The problem of the development
of functional literacy of students in Russia was actualized in 2018 thanks to the
Decree of the President of the Russian Federation dated May 7, 2018 No. 204 «On national
goals and strategic objectives of the development of the Russian Federation for
the period up to 2024», according to which it is necessary to ensure the global competitiveness
of Russian education, the entry of the Russian Federation into the top 10
countries in the world in terms of the quality of general education education. Russian
education is faced with the task of educating a functionally literate person, that is, a
person who thinks and acts with a high degree of independence and responsibility,
who is able to obtain the knowledge he needs, and is able to freely use it to solve vital
tasks. Reading literacy, understood as the ability of students to comprehend texts of
various contents and formats, as the ability to use what they read in various life situations,
including to achieve their goals, expand knowledge and opportunities, becomes
a significant result of education. In recent decades, society has realized the importance
of continuing education, which is associated with the need for a person to change several
types of activities during his life. The ability to read can no longer be considered
an ability acquired at an early school age, and can only be reduced to mastering the
technique of reading. Now it is a constantly developing set of knowledge, skills and
abilities, i.e. the quality of a person who improves throughout his life in different situations
of activity and communication.
A verdade os libertará!? Autoprodução de um sistema religioso confessional
Authors: Figur Elvio Nei
Published: November 2024

Uma leitura histórico-filosófica do sistema religioso missouri-ielbiano demonstra,
em suas estruturas basais, uma compreensão de verdade religiosa como verdade objetiva.
A lente da sociologia de Niklas Luhmann ajuda a revelar irritações que levaram o sistema a
se autoproduzir em uma postura confessional rígida pautada nessa compreensão. Essa
dinâmica, observada tanto na LCMS como na IELB, fica evidenciado na premissa da missão
missouriana: combate ao erro e proclamação da verdade. A coexistência de conservadores,
moderados e evangelicais demonstra, atualmente, que o sistema continua sujeito a
irritações e autopoieses. Essa leitura do campo humano da religião leva a um segundo
momento do texto, mais normativo, onde as lentes filosófico-teológicas de Martinho Lutero,
Søren Kierkegaard e Paul Tillich apontam a necessidade de o sistema devolver à fé seu
caráter de incondicionalidade e à religião, o elemento da auto-crítica. A partir disso são
listados ‘rudimentos’ para uma postura confessional [mais] libertadora.
ОСОБЕННОСТИ ДВУМЕРНОЙ ПЕЧАТИ ЛЕКАРСТВЕННЫХ ФОРМ В ФАРМАЦЕВТИЧЕСКОЙ ТЕХНОЛОГИИ
Authors: К.В. Алексеев , Е.В. Блынская , С.В. Тишков , В.К. Алексеев , А.А. Иванов , С.В. Минаев , С.Э. Кондаков , Е.С. Ихалайнен
Published: November 2024

В данном обзоре литературы рассмотрены основные технологические приемы, используемые в методе двумерной печати. Представлены разновидности технологий струйной и ротационной печати, особенности, преимущества и недостатки различных типов двумерной печати, например непрерывной струйной печати или печати по требованию. Показаны особенности производства и применения 2D-печатных лекарственных форм (оральнодиспергируемые, мукоадгезивные пленки и т.д.). Приведены примеры используемых подложек и технологии их производства с заданными характеристиками, а также требования и рецептуры используемых в печати растворов с фармацевтическими субстанциями. Изложены перспективы развития технологии 2D-печати и возможности ее применения, в частности в виде QR-кодированных лекарственных форм.

This review of the literature discusses the main technological methods used in the two-dimensional printing method. The varieties of inkjet and rotational printing technologies are presented, the features, advantages and disadvantages of various types of two-dimensional printing, for example, continuous inkjet printing or printing on demand. The features of the production and use of 2D-printed dosage forms (oral dispersible, mucoadhesive films, etc.) are shown. Examples of the substrates used and the technology of their production with given characteristics, as well as the requirements and formulations of the solutions used in printing with pharmaceutical substances are given. The prospects for the development of 2D-printing technology and the possibilities of its application, in particular in the form of QR-coded dosage forms, are set forth.
ОПРЕДЕЛЕНИЕ ЧИСТОТЫ НОВОЙ ФАРМАЦЕВТИЧЕСКОЙ СУБСТАНЦИИ 4,4’-(ПРОПАНДИАМИДО)ДИБЕНЗОАТ НАТРИЯ ХРОМАТОГРАФИЧЕСКИМИ МЕТОДАМИ
Authors: Ю.Э. Генералова , В.Ф. Апраксин , Г.М. Алексеева
Published: November 2024

Разработаны и валидированы методики определения родственных примесей и остаточных органических растворителей для определения чистоты ранее незарегистрированной фармацевтической субстанции 4,4’-(пропандиамидо)дибензоат натрия с использованием методов высокоэффективной жидкостной хроматографии и газовой хроматографии.

For determination purity of novel active pharmaceutical ingredient in the research, procedures were developed, validated and tested for the determination of related impurities (4-aminobenzoic acid, 4-((3-oxo-3-ethoxypropanoil)amino)benzoic acid, 4-(carboxyacetyl)amino)benzoic acid and malonic ester) and residual organic solvents (o-xylene) in the new pharmaceutical substance 4,4'-(propanediamido)dibenzoate sodium using high performance liquid chromatography and gas chromatography.
ОПРЕДЕЛЕНИЕ СОДЕРЖАНИЕ ИЗОФЛАВОНОВ В СУХОМ ЭКСТРАКТЕ ТРАВЫ КЛЕВЕРА ЛУГОВОГО МЕТОДОМ ВЭЖХ
Authors: Т.Ш. Нгуен , Г.М. Алексеева , Ю.Э. Генералова , И.Е. Каухова , В.В. Сорокин
Published: November 2024

Клевер луговой, также известный как красный клевер (Trifolium pratense L.), является природным источником фитоэстрогенных изофлавоноидов. Цель исследования-изучение качественного и количественного определения индивидуальных изофлавонов в сухом экстракте травы клевера луговогометодом ВЭЖХс целью расширения спектра лекарственных препаратов на основе данной фитосубстанции.В сухом экстракте травыклевера луговогобыли идентифицированы дайдзеин, генистеин, формононетин, прунетин и биоханинA, определено их содержание 0,360,01, 0,840,01, 3,020,05, 0,220,01 и 1,620,03 соответственно.Установленное значительное содержание в сухом экстрактеформононетинаибиоханинаAпозволяет рассматривать сухой экстракт клевера лугового как перспективную субстанцию для разработки лекарственных препаратов.

Clover meadow, also known as red clover (Trifolium pratense L.), is a natural source of phytoestrogenic isoflavonoids. The purpose of the study-to study the qualitative and quantitative content of individual isoflavones in the dried extract of red clover grass by HPLC in order to expand the range of medicines based on this phytosubstance. In the dried extract of red clover grass, daidzein, genistein, formononetin, prunetin and biochanin A were identified, their content was determined 0.360.01, 0.840.01, 3.020.05, 0.220.01 and 1.620.03 respectively. The established significant content in the dried extract of formononetin and biochanin A allows us to consider the dried extract of red clover grass as a promising substance for the development of medicines.
ГЕЛИ КАК ЛЕКАРСТВЕННАЯ ФОРМА В ГОСУДАРСТВЕННОЙ ФАРМАКОПЕЕ XIV ИЗДАНИЯ, НОРМАТИВНО-ПРАВОВЫХ АКТАХ МИНЗДРАВА РОССИИ И ГОСУДАРСТВЕННОМ РЕЕСТРЕ ЛЕКАРСТВЕННЫХ СРЕДСТВ
Authors: Г.Н. Ковальская , Е.Н. Михалевич , Е.С. Колмакова
Published: November 2024

Методом контент-анализа проведено исследование нормативной документации и данных Государственного реестра лекарственных средств по номенклатуре и классификации гелей. Проведен анализ ассортимента лекарственных препаратов, представленных лекарственной формой гель. Приведены результаты анализа отечественного фармацевтического рынка гелей по торговым наименованиям, фармакотерапевтическим группам, странам-производителям, референтности и взаимозаменяемости. Актуальным направлением является разработка отечественных гелей с позиции импортозамещения препаратов зарубежного производства.

Article includes content analysis of regulatory documentation and data from the State Register of Medicines by gels nomenclature and classification. The analysis of the assortment of gels is carried out. The results of the analysis of the domestic pharmaceutical gel market by trade names, pharmacotherapeutic groups, producer countries, reference and interchangeability are presented. An urgent direction is the development of gels of domestic production from the standpoint of import substitution of foreign drugs.
Морфолого-анатомическое изучение травы золотарника канадского (Solidagocanadensis L.)
Authors: И.С. Сулоев , О.В. Яковлева , Н.А. Дудецкая , В.Г. Лужанин
Published: November 2024

В работе представлено морфологическое описание травы золотарника канадского (Solidago canadensis L.), а также микроскопическое описание всех входящих в нее частей: листьев, стеблей, листочков обвертки, цветков и семянок. Выявлены характерные морфолого- и анатомо-диагностические признаки. Полученные результаты предлагается использовать для усовершенствования нормативной документации на траву золотарника канадского.

In this work the morphological description of the herb of Canadian goldenrod (Solidago canadensis L.) and microscopic description of all included parts (leaves, stems, wrapper leaves, flowers and achenes) are presented. The characteristic morphological and anatomical diagnostic signs are revealed. The obtained results are proposed to be used to improve the regulatory documentation for the herb of Canadian goldenrod.
Изучение противовоспалительной и гастропротективной активности плодов софоры японской (Sophora japonica L.)
Authors: И.А. Лупанова , Е.Н. Курманова , Е.В. Ферубко , О.Л. Сайбель , И.А. Мартынчик , Т.Е. Трумпе
Published: November 2024

Для изучения противовоспалительной и гастропротективной активности фракций из плодов софоры японской (Sophora japonica L.) проведены скрининговые исследования в условиях опытов in vitro с применением специфической ферментной биотест-системы на основе индуцибельной NO-синтазы. Было установлено, что гликозидная фракция, представленная гликозидами генистеина, кверцетина и кемпферола, проявляет противовоспалительную активность. В результате проведенных фармакологических исследований в условиях опытов in vivo на лабораторных животных установлено, что гликозидная фракция из плодов софоры японской является малотоксичной, оказывает достоверно выраженное противовоспалительное и гастропротективное действие и перспективна для дальнейшего изучения и создания новых эффективных лекарственных растительных препаратов.

It was studied pharmacological activity using biological screening of fractions from fruits Sophora japonica with NO-syntase specific enzyme biotest in vitro and with biological models in vivo. The glycoside fraction represented by genistein, quercetin and campferol glycosides has anti-inflammatory activity. It has been found that the glycoside fraction from fruits Sophora japonica is low-toxic and has a reliable anti-inflammatory and gastroprotective effect. This fraction is prospective for further study and new effective drug development.
ДИСТАНЦИОННАЯ ТОРГОВЛЯ ЛЕКАРСТВЕННЫМИ ПРЕПАРАТАМИ: ОГРАНИЧЕНИЯ И ПЕРСПЕКТИВЫ
Authors: И.А. Занина
Published: November 2024

Представлены результаты исследования потребительских мнений относительно дистанционной торговли лекарственными препаратами на российском фармацевтическом рынке. Сегмент электронного коммерческого фармацевтического рынка сегодня занимает более 6,5% от суммарного фармретейла и является привлекательной сферой деятельности. В октябре 2015 года Минздрав России выступил с предложением упорядочить рынок торговли лекарственными препаратами безрецептурного отпуска дистанционным способом. Поскольку реализация лекарственных препаратов через офлайн-аптеки и интернет-аптеки имеет явные различия, было проведено анкетирование потребителей на тему отношения к онлайн-покупкам, в том числе лекарственных препаратов. Установлено, что большинство респондентов совершают покупки в онлайн-магазинах. Треть респондентов планирует приобретать лекарственные препараты дистанционно в онлайн-аптеках и примерно столько не отрицают такой возможности, но при отсутствии лекарственного препарата в классической аптеке. Основными причинами предпочтения офлайн-аптек их интернет-конкурентам респонденты считают важность консультации и помощи фармработников и риск приобретения некачественного лекарственного препарата в онлайн-аптеке. Сформулирован вывод, заключающийся в готовности потребителей к легализации дистанционной продажи безрецептурных ЛП с возможностью доставки товаров на дом.

The article presents the results of a study of consumer opinion regarding remote selling of medicines on the Russian pharmaceutical market. Today, the e-commerce pharmaceutical market segment accounts for more than 6.5% of the total pharmaceutical retail and is an attractive area of activity. In October 2015, the Russian Ministry of health made a proposal to regulate the market for nonprescription medicines remotely. Since the sale of medicines through offline pharmacies and online pharmacies has clear differences, a survey of consumers on the attitude to online buying, including medicines, was conducted. It was found that the majority of respondents make buying in online stores. A third of respondents plan to buy medicines remotely in online pharmacies, and about the same number do not deny this possibility, but in the absence of a drug in a classic pharmacy. Respondents believe that the main reasons for choosing offline pharmacies over their online competitors are the importance of consultation and assistance from pharmacists and the risk of buying a low-quality drug in an online pharmacy. The conclusion is formulated that consumers are ready to legalize the remote sale of nonprescription medicines with the possibility of delivering goods to their homes.
Отношение населения Республики Саха (Якутия) к здоровью и его место в системе жизненно важных социальных ценностей
Authors: C.М. Тарабукина , Н.Б. Дрёмова , С.В. Соломка
Published: November 2024

Проведен интернет-опрос 100 респондентов Республики Саха (Якутия) по специально подготовленной оригинальной анкете «Лекарственные средства в нашей жизни», содержащей свыше 80 вопросов (1 полугодие 2020 г.). Получена статистическая информация по следующим блокам: социально-демографический портрет респондентов, медицинский портрет, медицина и общество, отношение к жизненно важным ценностям, отношение к здоровью, личностные характеристики современных пациентов, способствующие росту заболеваемости населения проблемы общества, отношение к болезням, проблемы современной медикализации. Доказана гипотеза исследования о постоянном росте медицинской и фармацевтической осведомленности населения отдельных территорий на примере Республики Саха (Якутия).

A remote Internet survey of 100 respondents of the Republic of Sakha (Yakutia) was carried out using a specially prepared original questionnaire "Medicines in our life", containing over 80 questions (1 half of 2020). Statistical information was obtained on the following blocks: socio-demographic portrait of respondents, medical portrait, medicine and society, attitude to vital values, attitude to health, personal characteristics of modern patients, contributing to an increase in the incidence of the population, problems of society, attitude to diseases, problems of modern medicalization. The hypothesis of the study on the constant growth of medical and pharmaceutical awareness of the population of certain territories is proved by the example of the Sakha Republic (Yakutia).
ОБОСНОВАНИЕ ВЫБОРА МЕТОДИКИ СТАНДАРТИЗАЦИИ ТРАВЫ ЦИКОРИЯ ОБЫКНОВЕННОГО (CICHORIUM INTYBUS L.)
Authors: О.Л. Сайбель
Published: November 2024

Одним из перспективных объектов исследования в направлении разработки новых лекарственных растительных средств является цикорий обыкновенный. Надземная часть этого растения может быть заготовлена как от дикорастущих растений, так и использована в качестве вторичного сырья при промышленном культивировании корней. В результате проведенных исследований установлено, что содержание суммы фенольных соединений в сырье дикорастущих растений составляет от 2,02±0,01 до 6,25±0,29%, культивируемых сортов - от 3,04±0,14 до 4,04±0,17%. Доминирующим соединением во всех образцах сырья является цикориевая кислота. В сырье культивируемых растений, в отличие от дикорастущих, отсутствуют оксикумарины. Изучение влияния на гуморальное звено иммунитета экстрактов, полученных из культивируемых и дикорастущих растений, показало их сопоставимую активность, что свидетельствует об отсутствии вклада оксикумаринов в данный эффект. В связи с этим для стандартизации сырья дикорастущих и культивируемых растений может быть использована методика количественного определения суммы фенольных соединений в пересчете на цикориевую кислоту.

The chicory (Cichorium intybus L.) is one of promising objects in research and direction of new herbal medicinal products and development of its. The aerial part of this plant can be harvested both from wild plants and used as a secondary raw material in the industrial cultivation of roots. This plant material contains a complex of phenolic compounds. As a result of the studies, it was found that the content of the sum of phenolic compounds in the raw material of wild plants is from 2.02±0.01 до 6,25±0,29%, cultivated varieties from 3.04±0.14 to 4.04±0.17%. Cichoric acid is the dominant compound in all samples. Oxycoumarins are absent in the raw materials of cultivated plants, but it contains in wild ones. Study of effect extracts obtained from cultivated and wild plants showed their comparable activity on the humoral link of immunity, which indicates the absence of the contribution of oxycoumarins to this effect. In this regard, the standardization technique of quantitative determination of the phenolic compounds in calculation on cichoric acid in wild and cultivated plants raw materials is could be used.
ИССЛЕДОВАНИЕ ФИЗИКО-ХИМИЧЕСКИХ И ТЕХНОЛОГИЧЕСКИХ СВОЙСТВ ОСНОВЫ ДЛЯ РЕЗИНОК ЖЕВАТЕЛЬНЫХ ЛЕКАРСТВЕННЫХ HEALTH IN GUM®
Authors: С.В. Тишков , Е.В. Блынская , К.В. Алексеев , В.В. Буева , В.К. Алексеев
Published: November 2024

Резинки жевательные лекарственные - лекарственная форма, которая набирает популярность благодаря удобству применения (не требует воды), постепенному высвобождению лекарственных средств в полости рта, снижению риска проявления побочных эффектов из-за отсутствия прямого контакта со слизистой желудка и другим преимуществам. В данном исследовании продемонстрированы физико-химические и технологические свойства основы для приготовления резинок жевательных лекарственных (гуммиосновы) Health in Gum® PWD-04 путем прямого прессования. Проведен анализ полученных данных и сделан вывод о применимости технологического процесса прямого прессования для изученной марки гуммиосновы.

Chewing gum - a dosage form that is gaining popularity due to its ease of use (does not require water), the gradual release of drugs in the oral cavity, and the risk of side effects due to the lack of direct contact with the gastric mucosa and other benefits. This study demonstrated the physicochemical and technological properties of the base for the preparation of Health in Gum® PWD-04 chewing gum (gum bases) by direct compression. The analysis of the data obtained is carried out and a conclusion is drawn on the applicability of the direct compression process for the studied brand of gum base.
ПРИМЕНЕНИЕ ИК-ФУРЬЕ СПЕКТРОСКОПИИ ДЛЯ УСТАНОВЛЕНИЯ ПОДЛИННОСТИ СЕМЯН ЧЕРНУШКИ ПОСЕВНОЙ
Authors: Н.А. Давитавян , Е.Б. Никифорова , А.В. Никулин , С. Лазар
Published: November 2024

В работе показана возможность применения метода ИК-Фурье спектроскопии для целейустановления подлинности семян чернушки посевной и получаемых из них фармацевтических продуктов. В этом случае наиболее целесообразно проведение идентификации растительных объектов чернушки посевной по наличию тимохинона, который является одним из основных действующих веществ и в значительной мере обусловливает ее фармакотерапевтический потенциал. Предложенный ИК-Фурье спектроскопический метод может быть использован для оценки качества семян чернушки, масла черного тмина и сверхкритического углекислотного экстракта.

The paper demonstrates the possibility of using the method of FTIR spectroscopy for the purpose of establishing the authenticity of the seeds of nigella sowing and the pharmaceutical products obtained from them. In this case, it is most expedient to identify plant objects of nigella sowing by the presence of thymoquinone, which is one of the main active substances and, to a large extent, determines its pharmacotherapeutic potential. The proposed FTIR spectroscopic method can be used to assess the quality of nigella seeds, black cumin oil and supercritical carbon dioxide extract.
ТЕОРЕТИЧЕСКОЕ ОБОСНОВАНИЕ ВЫБОРА ЛЕКАРСТВЕННОГО РАСТИТЕЛЬНОГО СЫРЬЯ ДЛЯ СОЗДАНИЯ СБОРА, ПРЕДНАЗНАЧЕННОГО ДЛЯ ЛЕЧЕНИЯ САХАРНОГО ДИАБЕТА 2-ГО ТИПА
Authors: М.А. Джавахян , Н.Р. Павец , О.К. Павельева
Published: November 2024

В статье освещены вопросы, связанные с состоянием заболеваемости населения сахарным диабетом. Представлена концептуальная модель поддержания гомеостаза глюкозы в процессе приема пищи и после него, предложенная Мухамеджановым Э.К. Дана характеристика растений и механизм действия биологически активных веществ (БАВ), способствующих комплексному воздействию на патологический процесс при лечении сахарного диабета 2-го типа. Среди них: корни и корневища девясила, сем. астровые (Inula helenium L., сем. Asteraceae), богатые инулином, который может быть использован в качестве пребиотика для модуляции микробиоты кишечника, что потенциально влияет на гомеостаз глюкозы и липидный профиль; листья брусники обыкновенной, сем. вересковые (Vaccinium vitis-idaea L., сем. Ericaceae), содержащие в себе дубильные вещества и арбутин, который в индивидуальном виде является в настоящее время перспективным веществом для борьбы с диабетической нефропатией; плоды шиповника собачьего, сем. розовые (Rosa canina L., сем. Rosaceae), обладающие большим набором биологически активных веществ (исследования показали, что плоды шиповника противодействуют ожирению и диабету); трава пустырника сердечного, сем. яснотковые (Leonurus cardiaca L., сем. Lamiaceae), которая богата флавоноидами - рутином, апигенином и др. Рутин снижает всасывание углеводов из тонкого кишечника, стимулирует секрецию инсулина бета-клетками, защищает островок Лангерганса от дегенерации, увеличивает поглощение глюкозы тканями и подавляет глюконеогенез в печени. Показана целесообразность использования растительной композиции из корней и корневищ девясила высокого, листьев брусники, плодов шиповника и травы пустырника, которые являются источниками инулина и инулицина, арбутина, витамина С и органических кислот, рутина и апигенина.
АНТИОКСИДАНТНАЯ АКТИВНОСТЬ ПОБЕГОВ ПЕРВОГО ГОДА RUBUS IDAEUS (L.)
Authors: Д.К. Гуляев , В.Д. Белоногова , Д.О. Боков , В.В. Бессонов
Published: November 2024

Цель - исследовать фенольные соединения и антиоксидантную активность сухого водного экстракта побегов первого года малины обыкновенной - Rubus idaeus (L.). В качестве объектов исследования выступали образцы побегов первого года малины, заготовленные на территории Ильинского района Пермского края в ельнике травяном в июне 2019 года. Молодые побеги длиною до 30 см срезали и высушивали воздушно-теневым способом. Анализ фенольных соединений проводили на жидкостном хроматографе марки Agilent 1100 Series HPLC. Для определения антиоксидантной активности использовали реакцию со стабильным свободным радикалом 2,2-дифенил-1-пикрилгидразилом (DPPH). В результате хроматографического исследования в сухом водном экстракте побегов малины обыкновенной первого года было идентифицировано 12 веществ фенольной природы. В наибольшем количестве в сухом экстракте побегов малины содержится эллаговая, бензойная, ванилиновая кислоты, ванилин и флавоноид гиперозид. Сухой водный экстракт побегов малины обыкновенной проявляет выраженную антиоксидантную активность (IC50 – 43,86 мкг/мл). Данный показатель превышает активность настоя плодов шиповника в пересчете на сухой остаток (IC50– 76,75 мкг/мл), но уступает по выраженности антиоксидантного действия субстанции аскорбиновой кислоты (IC50 - 9,46 мкг/мл). Сухой водный экстракт побегов малины первого года можно рекомендовать для дальнейших исследований антиоксидантной и других видов фармакологической активности.

Purpose - to make a research of phenolic compounds and antioxidative activity of dry aqueous extract of Rubus idaeus (L.) one-year shoots. The objects of the research were the samples of one-year shoots of red raspberry - Rubus idaeus (L.). Raspberry shoots were collected on the territory of the Ilyinsky district of the Perm Region in an herbaceous-spruce forest in June 2019. Young one-year shoots, up to 30 centimeters in length, were cut and dried with the shade drying method. Phenolic compounds were analyzed with a liquid chromatograph Agilent 1100 Series HPLC. Antioxidative activity was determined by using a stable radical 2,2-diphenyl-1-picrylhydrazyl (DPPH) reaction. As a result of the chromatographic research, 12 substances of phenolic nature were identified in a dry aqueous extract of the red raspberry one-year shoots. The most substances in the raspberry shoots dry extract are: ellagic acid, benzoic acid, vanillic acid, vanillin and the flavonoid hyperoside. Dry aqueous extract of red raspberry one-year shoots shows significant antioxidative activity (IC50 – 43.86 μg/ml). This index is above the activity of the sweet-brier fruits infusion in terms of dry residue (IC50 – 75.76 μg/ml), but is inferior to the substance of ascorbic acid in the severity of the anti-oxidant action (IC50 - 9.46 μg/ml). Dry aqueous extract of raspberry one-year shoots can be recommended for further researches of antioxidative activity and other types of pharmacological activity.