bluuebunny/crossref_metadata_2025 huggingface dataset:
ITiCSE 2024: Call for Participation
Authors: Lonati Violetta , Monga Mattia , Barendsen Erik
Published: June 2024

The 29th ITiCSE is approaching: this year the conference will be hosted by the University of Milan (Italy), which is also celebrating its 100
th
birthday this year. We look forward to welcoming you there from July 5 to 10, 2024.
Pioneering Microporous Layers for Proton-Exchange-Membrane Water Electrolyzers via Tape Casting
Authors: Lee Jason K. , Lau Grace Y. , Shen Fengyu , Bergeson-Keller Anyka , Peng Xiong , Tucker Michael C.
Published: June 2024

The imperative shift towards decarbonization necessitates the production of clean hydrogen through water electrolysis, powered by renewable energy sources. Among electrolyzer technologies, proton-exchange-membrane (PEM) systems emerge as a promising option for large-scale hydrogen generation due to their modular design and rapid response, aligning well with the intermittency of renewable energy. In this study, we employ a tape casting method to fabricate microporous layers (MPLs), both as a single layer and as a bilayer over commercial porous transport layers (PTLs), to further enhance performance of water electrolyzers. We demonstrate that microporous layers require adequate pore sizes to facilitate gas removal, preventing gas flooding and preserving electrolyzer performance. Our single layer microporous layers exhibit lower overpotentials compared to commercial sintered Ti PTLs by 142 mV at 4 A·cm⁻2. Moreover, we show that having an effective microporous layer enhances electrolyzer performance irrespective of the substrate used, offering avenues for cost reduction. We also investigate novel PTL structures with reduced tortuosity and integrated MPL fabricated via phase inversion tape casting, resulting in a performance enhancement of 92 mV. Our findings unravel the critical role of microporous layer structures and their impact on electrolyzer performance.
The use of role-play in the learning of medical terminology for online and face-to-face courses
Authors: del Moral Brenda L. M. , VanPutte Cinnamon L. , McCracken Barbara A.
Published: June 2024

Role-play can engage students and encourage learning in identification, pronouncing, writing, and understanding medical terminology in multiple course formats.
Elucidation of the pathophysiology of interstitial cystitis/bladder pain syndrome via experimental autoimmune cystitis rat model
Authors: Kadekawa Katsumi , Nishijima Saori , Noguchi Katsuhiko , Matsumoto Seiji , Sugaya Kimio
Published: June 2024

The experimental autoimmune cystitis model rats showed pain and frequent urination with the overexpression of inflammatory chemokines, reflecting clinical interstitial cystitis/painful bladder syndrome (IC/PBS), and the bladder epithelium and vascular endothelium may be the primary sites of IC/BPS, and bladder injury, such as bladder distension, can cause progression from BPS to IC with Hunner lesions.
Assessment of Traffic‐Related Ambient Air Particulate Matter (PM) Levels in Douala, Cameroon
Authors: Ngangmo Yannick Cédric , Adiang Mezoue Cyrille , Meukaleuni Cyrille , Wandjie Brice B. S. , Monkam David
Published: June 2024

A challenge in many Sub‐Saharan African (SSA) cities is the absence of air quality monitoring due to the high expense and technical expertise needed. Air pollution around the world is becoming a societal problem, and developed countries have all the necessary information about the levels of most air pollutants; however, underdeveloped countries have inadequate information on air quality. The problem of poor air quality in many SSA countries is due to lack of information about the hazards of poor air quality, lack of monitoring equipment, and lack of measuring stations: this is the case in Cameroon. We are avoiding these problems by using portable, low‐cost, low‐maintenance air quality monitoring equipment, including the OC 300 dust particle laser, to observe pollution levels of particle matter levels in the PK17 Douala‐Cameroon, a locality in the Central African region where no air quality data previously existed. The air quality index is very poor on the measurement days, and the color code is red. It has maximum values of about 199 for PM10 and 192 for PM2.5. The average concentration values obtained were of the order of 200.54 µg·m−3, 155.54 µg·m−3, 194.90 µg·m−3, and 194.03 µg·m−3 for PM10, respectively, on Tuesday, Thursday, Saturday, and Sunday. Regarding PM2.5, the average concentrations are 99.84 µg·m−3, 82.30 µg·m−3, 108.23 µg·m−3, and 112.97 µg·m−3, respectively, on Tuesday, Thursday, Saturday, and Sunday. A two‐dimensional Gaussian model was used to estimate the particle matter concentration along each road. The nRMSE was 9% for PM10 and 12 for PM2.5, and the index-d for both particle sizes was close to 1 (0.74 for PM10 and 0.98 for PM2.5), which allows us to conclude that the calculated concentrations are the closest to the measured concentrations. The assessment reveals that most of the particulate matter during the measurement period was generated by road traffic. The concentration measured values of the pollutants are three times for PM2.5 and four times for PM10 above the recent WHO limits for daily exposure. In addition, it provides essential information on the pollution in Douala, which can be a major source of illness in the city and must be addressed.
Influence of Solid Waste Oyster Shell Powder on the Physical and Swell–Shrink Properties of Expansive Soils
Authors: Ye Daohua , Li Shiwen , Li Zengyuan , Shao Yu , Zhou Yuzhu , Huang Zhen , Bian Linlin
Published: June 2024

To explore the effects of solid waste oyster shell powder (SWOSP) on the physical and swell–shrink properties of expansive soils, the expansive soil in Ningming, Guangxi province (the classification code of soil is CH), was taken as the research object. A series of tests were carried out on the physical and swell–shrink properties of expansive soil samples with OSP contents of 0%, 3%, 6%, 9%, and 12%. The results show that the incorporation of OSP can effectively enhance the integrity of the soil, change the distribution of the particle size of the expansive soil, and effectively reduce the expansion and contraction of the soil. The free swelling ratio, unloaded swelling ratio, loaded swelling ratio, swelling force, and linear shrinkage rates of the tested soil decreased with increasing OSP content and stabilized when the OSP content was 9%. The research results provide theoretical basic data for the improvement of expansive soil with oyster shell powder and also offer a new approach for green engineering.
Microaxial Flow Pumps for Cardiogenic Shock: Effects on Hemodynamics, Hemolysis, and End‐Organ Recovery
Authors: Parker Lauren E. , Kang Lillian , Milano Carmelo A. , Lobo Alejandro A. , Doberne Julie W. , Bishawi Muath , Jensen Christopher. W. , Patel Chetan B. , DeVore Adam D. , Russell Stuart D. , Katz Jason N. , Schroder Jacob N.
Published: June 2024

Background. The Impella 5.5 offers a less invasive transvalvular approach to left ventricular mechanical support. End‐organ recovery and hemolysis have been well‐studied with durable left ventricular assist devices but effects of Impella 5.5 on these parameters are less well described. Methods. All Impella 5.5 recipients between August 2020 and June 2023 were reviewed from a single institution. Hemodynamics and laboratory values were compared between preimplant and prior to device removal. Hemolysis was defined as postoperative lactate dehydrogenase >1000 IU/L with concurrent plasma‐free hemoglobin >50 mg/dL. Paired Wilcoxon tests compared the median of differences between preimplant and pre‐explant values. Results. We studied 127 consecutive implants of the Impella 5.5. Thirty‐one patients had concomitant VA‐ECMO, and one received Impella 5.5 after durable LVAD explant; these cases were excluded. Our final cohort included 95 patients, with an average age of 55.29 ± 14.5 years. Median implant duration was 11 days (IQR:6–16 days). To avoid confounding hemodynamic factors, we restricted hemodynamic analysis to the 37 patients who received isolated Impella 5.5, excluding those with prior IABP, Impella CP, acute MI, or prior cardiac surgery. These patients experienced improvements from baseline in pulmonary vascular resistance (−77.03 dynes/sec/cm−5, p < 0.01) and wedge pressure (−6.5 mmHg, p < 0.01). Furthermore, cardiac index improved from baseline (+1.3, p < 0.01). In the total cohort (n = 95), pre‐explant creatinine (−0.2 mg/dL, p < 0.01) and ALT (−9.0 mg/dL, p < 0.01) decreased relative to values before the implant. Twenty‐three (24%) met criteria for hemolysis; however, none underwent device removal for clinically significant hemolysis. Takeback was required in 25 patients, 22 of which were for axillary hematoma. Conclusions. Impella 5.5 support acutely improved markers of end‐organ function and hemodynamics, including PVR.
Chondroma in the Urinary Bladder: An Extremely Rare Finding
Authors: Porto Joao G. , Blachman-Braun Ruben , Khandekar Archan , Kryvenko Oleksandr N. , Parekh Dipen J.
Published: June 2024

Chondroma, commonly observed in the bones, has limited documentation when found in soft tissues. To date, only 8 chondromas in the urinary bladder have been reported, all in females. Here, we describe a 54‐year‐old female who presented with a chondroma located at the anterior wall of the urinary bladder. An incidental 5 mm enhanced focus was identified on the right bladder wall during a contrast‐enhanced computerized tomography (CT). Subsequent cystoscopy did not reveal any abnormalities, and both urinalysis and urine cytology were unremarkable. However, a CT urogram reconfirmed suspicions of malignancy, which a cystoscopy validated. The patient underwent a transurethral resection of the bladder tumor, which was identified as a bladder chondroma. During the surgical incision, a submucosal lesion was found, which was further confirmed with histopathological evaluation. Over a year‐long follow‐up using imaging and urine cytology, no recurrence was observed. This case reinforces earlier findings and underscores the predilection for females between their 5th and 7th decades with a positive prognosis.
Dynamic Optimization of Inventory: A Comprehensive Model Incorporating Price‐Sensitive Stochastic Demand, Promotional Strategies, Rework, Preservation Technology, and Carbon Emission Reduction
Authors: Palanivel M. , Venkadesh M. , Vetriselvi S. , Sundararajan R.
Published: June 2024

This paper presents an inventory model with a price‐dependent stochastic demand and finite replenishment rate mode. It establishes a production‐inventory system with a controllable deterioration rate, preservation technology, different types of rework process, promotional effort, and carbon emission reduction. This study finds the optimal solution and determines the most efficient production and safety technology investments to maximize the manufacturer’s total profit over the planning horizon. Also, this inventory model balances sustainability and profitability to maximize the profit and to determine the optimal cycle length. In addition, the research highlights the most advantageous investments in production and preservation technology, emphasizing their critical role in increasing profitability and identifying the most effective duration of the production cycle. The study presents a comprehensive approach to inventory optimization that tackles practical and strategic challenges in manufacturing contexts. This research refers to cases and numerical examples, providing management insights and sensitivity analysis to determine the optimal course of action to change the parameters of the model.
Trypanosome Infection in Cattle and Associated Vectors in Etang District of Gambella, Ethiopia
Authors: Tola Negesa , Wagari Akinaw , Lemu Geremew Haile , Kedir Mohamed , Gebremeskel Haben Fesseha , Kebede Isayas Asefa
Published: June 2024

Background. Bovine trypanosomosis produces significant economic losses due to anemia, loss of body condition, and emaciation. The disease is transmitted biologically by tsetse flies and mechanically by biting flies such as Tabanus and Stomoxys. Therefore, this research is aimed at estimating the prevalence of bovine trypanosomosis and the apparent density of its vectors in the Etang Special District. Methods. A cross‐sectional study was employed from November 2016 to April 2017 for the prevalence and entomological survey. Trypanosoma species were identified using buffy coat and Giemsa staining techniques. Besides, the entomological surveys were conducted using NGU, pyramidal, biconical, and monoconical traps. The vectors were identified to their genus level based on their morphological features like size, color, wing venation, and proboscis. Result. A total of 457 bovine blood samples were collected and tested, of these 16 (3.50%) animals were positive for trypanosomosis. Similarly, 13 T. vivax (81.25%) and 3 T. congolense (18.75%) were the trypanosome species detected. The prevalence in the young (2.56%) and adult (3.99%) age groups was not statistically significant (P > 0.05). However, there were significant (P < 0.05) differences in prevalence between body condition scores, where poor is 6.31%, medium is 1.30%, and good is 0%. Moreover, the difference in mean PCV values between the parasitemic (20.97) and aparasitemic (28.58) groups was statistically significant (P < 0.05). Glossina flies were not found, although 1756 Tabanus and 52 Stomoxys biting flies were gathered. Accordingly, the overall apparent density of Glossina flies was zero (0), with biting flies (20.54) recorded per trap per day. Moreover, the apparent density of Tabanus and 52 Stomoxys was 39.01 and 1.18, respectively. Conclusion. This study confirmed that trypanosomosis and abundant mechanical vectors continue to be problems in the study area, resulting in cattle productivity losses. As a result, strategic management and prevention methods for trypanosomosis and associated vectors should be prioritized. Further investigation of vector needs to be conducted to clear out tsetse presence.
Strategies for the Isolation and Identification of Gastric Cancer Stem Cells
Authors: Wang Jianhua , Qu Jie , Hou Qiang , Huo Xueping , Zhao Xiangrong , Chang Le , Xu Cuixiang
Published: June 2024

Gastric cancer stem cells (GCSCs) originate from both gastric adult stem cells and bone marrow cells and are conspicuously present within the histological milieu of gastric cancer tissue. GCSCs play pivotal and multifaceted roles in the initiation, progression, and recurrence of gastric cancer. Hence, the characterization of GCSCs not only facilitates precise target identification for prospective therapeutic interventions in gastric cancer but also has significant implications for targeted therapy and the prognosis of gastric cancer. The prevailing techniques for GCSC purification involve their isolation using surface‐specific cell markers, such as those identified by flow cytometry and immunomagnetic bead sorting techniques. In addition, in vitro culture and side‐population cell sorting are integral methods in this context. This review discusses the surface biomarkers, isolation techniques, and identification methods of GCSCs, as well as their role in the treatment of gastric cancer.
Therapeutic and Prophylactic Effects of Fulvic Acid on a Breast Cancer Model Established by MCF‐7 Cell Line in SCID Mice
Authors: Gulcicek Osman Bilgin , Oran Duygu Sultan , Temizyurek Arzu , Yavuz Erkan , Yigitbas Hakan , Ercetin Candas , Solmaz Ali , Yildirim Funda , Sonmez Kivilcim , Celik Atilla
Published: June 2024

Introduction. There is still minimal scientific understanding of effects of fulvic acid (FA) on breast cancer. We investigated the prophylactic, therapeutic, and combined effects of FA in a breast cancer model created using MCF‐7 cell line in severe combined immunodeficiency disease (SCID) mice. Results. Four experimental groups were established as the control group (Group C), prophylaxis group (Group P), therapeutic group (Group T), and prophylaxis + therapeutic group (Group P + T). Tumor growth was observed by the in vivo imaging system and macroscopically in mammary glands of all mice (100%) of Group C, microscopically in only one mouse of Group P (12.5%), in four mice in Group T (50%), but only one animal (12.5%) in Group P + T. Immunohistochemistry (IHC) showed that p53 staining was significantly higher in tissues of Group C compared to other groups (P < 0.05). No difference was found in IHC scores for p53 between Group P and P + T (P > 0.05). Bcl‐2 staining was significantly higher in Group C compared to Group P + T (P = 0.015) and higher in Group P + T compared to Group T (P = 0.021) but no significant difference was found between Group P and others (P > 0.05). Bax staining was significantly higher in Group C compared to others (P < 0.05) but no significant difference was found between FA groups (P > 0.05). Conclusion. Prophylactic FA treatment can prevent tumor formation by inducing variations in the expression of p53, BcL‐2, and Bax proteins in mammary glands of SCID mice before tumor formation. This suggests that FA may be a powerful inhibitory candidate for the prevention of tumorigenesis in breast cancer.
Critical Evaluation of Global Infection Prevention and Control Guidelines for Dentistry Published during the First 2 Years of the COVID‐19 Pandemic
Authors: Alkurdi Khlood , Mansouri Rowaina , Ismail Aseel , Seoudi Noha
Published: June 2024

Objectives. The outbreak of the coronavirus disease (COVID‐19) encouraged immediate actions by governments and healthcare associations across the world to flatten the curve and prevent health systems from being overburdened. As dentistry comprises aerosol‐generating procedures (AGPs), which could increase the risk of infection, various guidelines were issued for dental services which focused on infection prevention and control (IPC) measures for COVID‐19. This systematic review focuses on dental IPC guidelines, with the aim of comparing these guidelines against a gold standard. Method. The Preferred Reporting Items for Systematic Reviews and Meta‐Analyses (PRISMA) 2020 checklist was employed. Predefined inclusion and exclusion criteria were constructed. Information sources comprised Google Scholar, PubMed, and a manual search from December 2019 to December 2021. The Appraisal of Guidelines for Research and Evaluation (AGREE II) instrument was used. Consensus scoring was applied for all guidelines. Results. A total 61 guidelines were included in the review. The UK national guideline was used as a gold standard as it ranked the highest AGREE score (75 out of 84) and thus was established for comparison with each of the included guidelines. Overall, 40% of the included guidelines had a high consensus score in relation to the UK national guideline. Conclusion. This systematic review highlighted the variability in content and quality of advice given by different organizations in response to the COVID‐19 pandemic in their efforts to reduce SARS‐CoV‐2 transmission in dentistry. Establishing a single worldwide fast‐acting dental organization would ensure that high‐quality standardized guidance is available, to enhance health equality and worldwide dental clinical standards.
Influence of Basalt Fiber on the Mechanical Properties and Deformation Failure of Concrete after High Temperature
Authors: Wang Yujing , Ren Qian , Xu Jianghong
Published: June 2024

This study was conducted to investigate how high temperatures and the addition of basalt fiber influence the mechanical behavior and failure characteristics of concrete. Two types of concrete were prepared: basalt fiber concrete (BFC), containing 1.0% basalt fiber by mass, and ordinary concrete (OC), without any fiber addition. The high‐temperature effects of 200, 400, 600, and 800°C were carried out, and the compressive strength test, variable angle shear test, and cyclic compression test were carried out. The results show that basalt fiber will not change the mechanical characteristics of concrete and the change trend of stress–strain curve with temperature. The mass loss rate of BFC is always lower than that of OC. With the increase in temperature, the compressive strength, elastic modulus, and deformation modulus of the two types of concrete gradually decrease, and the plastic strain and dissipation energy gradually increase. Basalt fiber delays the loss of compressive strength in concrete and significantly increases the elastic modulus and the ability to resist cyclic compression and shear. Basalt fiber enhances the cohesion and friction resistance between concrete particles, thereby improving the structural stability and shear resistance of concrete. The severe damage temperature range of OC is 200–400°C, and the severe damage temperature range of BFC is 400–600°C. Based on the Holmquist–Johnson–Cook model, the meso‐deformation and failure processes of OC and BFC were analyzed by LS‐DYNA software. It was found that OC showed obvious brittle failure characteristics. With the increase in temperature, basalt fiber began to oxidize and decompose, and the meso‐failure form of BFC changed from pullout failure to fracture failure.
Assessing the Safety of Hotel Food: Knowledge, Attitude, and Practices of Food Handlers
Authors: Segbedzi Cynthia Esinam , Ansah Edward Wilson , Apaak Daniel
Published: June 2024

Food safety is of global public health concern. Hotels and their restaurants provide hospitality like accommodation and food services and are spearheaded by food handlers who have varied experiences. This study was undertaken to examine knowledge, attitude, and practices (KAP) on food safety and explore knowledge‐practice gaps among food handlers at hotels in Ghana. There were 233 participants, including 205 food handlers, 10 managers/chefs, and 18 regulatory officials, who were at post after the COVID‐19 restrictions were eased on hotel and restaurant activities. Data were gathered through questionnaire with food handlers and face‐to‐face interview with managers/chefs and officials of the regulatory agencies. Frequencies and percentages, and Wilcoxon signed ranked test were employed to analyse the data. The knowledge on food safety was moderate, 58 ± 0.169, and 82% of the food handlers portrayed positive attitude towards food safety, while only 42.8% demonstrated good food safety practices. There was significant variance between knowledge and practice such that food handlers’ food safety knowledge did not reflect in their daily practices, yet most of the food handlers had training prior to being employed. Many people may be eating contaminated foods from hotels that may increase the rate of food‐borne illnesses. We suggest continuous training in transmission of food‐borne diseases and time and temperature control, and that the training should be obligatory to reinforce food handlers’ KAP. In addition, managers need to intensify their collaborations with the regulators to improve monitoring and supervision activities at the hotels.
Intelligent Decision‐Making System of Air Defense Resource Allocation via Hierarchical Reinforcement Learning
Authors: Zhao Minrui , Wang Gang , Fu Qiang , Quan Wen , Wen Quan , Wang Xiaoqiang , Li Tengda , Chen Yu , Xue Shan , Han Jiaozhi
Published: June 2024

Intelligent decision‐making in air defense operations has attracted wide attention from researchers. Facing complex battlefield environments, existing decision‐making algorithms fail to make targeted decisions according to the hierarchical decision‐making characteristics of air defense operational command and control. What’s worse, in the process of problem‐solving, these algorithms are beset by defects such as dimensional disaster and poor real‐time performance. To address these problems, a new hierarchical reinforcement learning algorithm named Hierarchy Asynchronous Advantage Actor‐Critic (H‐A3C) is developed. This algorithm is designed to have a hierarchical decision‐making framework considering the characteristics of air defense operations and employs the hierarchical reinforcement learning method for problem‐solving. With a hierarchical decision‐making capability similar to that of human commanders in decision‐making, the developed algorithm produces many new policies during the learning process. The features of air situation information are extracted using the bidirectional‐gated recurrent unit (Bi‐GRU) network, and then the agent is trained using the H‐A3C algorithm. In the training process, the multihead attention mechanism and the event‐based reward mechanism are introduced to facilitate the training. In the end, the proposed H‐A3C algorithm is verified in a digital battlefield environment, and the results prove its advantages over existing algorithms.
An Efficient Multisensor Hybrid Data Fusion Approach Based on Artificial Neural Networks and Particle Swarm Optimization Algorithms
Authors: Ihonock Luc Eyembe , Essiben Jean-François Dikoundou , Diboma Benjamin Salomon , Yong Joe Suk
Published: June 2024

Data fusion plays a crucial part in performance evaluation processes in multisensor systems; thus, it is important to use an effective technique to cut down on errors. By improving the sensors’ location and their capacity to adjust to the deployment geometry, the paper’s technique for reducing data fusion errors is proposed. The preprocessing stage of data is also included in the suggested technique, which starts with the design of the data‐collecting device and ends with a hybrid model algorithm. Particle swarm optimization and artificial neural network methods are combined in the hybrid algorithm. Preprocessing is based on the compensation and adjustment factors to ensure data gathering synergy. A true experimental apparatus was designed under three different deployment geometries, comprising five ultrasonic sensors constituting a multisensor system and a hardwood target (Triplochiton scleroxylon and Milicia excelsa). The results obtained show that the suggested deployment geometry has mean absolute percentage errors of 3.97, mean square errors of 0.182, and mean absolute errors of 0.045 which are lower than those associated with the deployment configurations found in the literature. The results of the proposed method show an overall detection accuracy in linear deployment geometry of 97.308%. Then, the circular deployment geometry obtained a detection accuracy of 97.005%. Finally, elliptical deployment geometry obtained a detection accuracy of 98.745%. These results show that the proposed method better predicts the range of a target with a lower error rate than conventional methods.
Figure S6 from Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma
Authors: Ward George A. , Zhang Zhiqiang , Jueliger Simone , Potapov Ilya S. , Davis Matthew P. , Boxall Adam R. , Taylor Jason , Keer Harold , Biondo Andrea , Lyons John F. , Sims Martin , Smyth Tomoko
Published: June 2024

Figure S6. Additional Karpas-299 cytokine data. (Refers to Figure 4)
Dasar-Dasar Digital Marketing: Teknologi, Media Sosial, dan Strategi
Authors: Nugroho Dian Ari , Suryadi Nanang
Published: June 2024

Perkembangan pemasaran terkini menunjukkan peningkatan aplikasi teknologi digital dalam strategi yang diformulasikan oleh marketer modern. Buku “DASAR-DASAR DIGITAL MARKETING: Teknologi, Media Sosial, dan Strategi” menjelaskan dunia pemasaran yang berkembang pesat dari sisi teknologi digital yang dimanfaatkan. Buku ini mengupas tuntas konsep-konsep dasar terkait pemasaran digital dalam 14 bab yang mudah untuk dipahami pembaca. Bab pertama, Overview Digital Marketing, pembaca diperkenalkan mengenai dasar-dasar pemasaran digital dan bagaimana teknologi telah merubah cara pemasar berinteraksi dengan konsumen. Berikutnya, Online Market Research, membantu pembaca memahami pentingnya penelitian pasar dalam pengambilan keputusan yang cerdas dalam lingkungan digital saat ini. Selanjutnya, dalam bab Contents Marketing, pembaca diajak untuk memahami konsep konten marketing yang marak saat ini yang dapat memainkan peran kunci dalam menarik audiens dan membangun merek. Kemudian User Experience Design, Web Design, membahas pentingnya desain web yang interaktif, responsif, dan desain pengalaman pengguna yang dapat memuaskan para konsumen. Bab-bab selanjutnya membahas Online CRM, Search Engine Optimation, Search Advertising, dan Online Advertising untuk membantu para pembaca memahami berbagai elemen teknis dalam pemasaran digital, termasuk manajemen hubungan pelanggan online, optimasi mesin pencari, dan periklanan online. Bab selanjutnya, Celebrity Endorsement dan Affiliate Marketing membahas tentang strategi penggunaan selebriti dan afiliasi dalam pemasaran digital. Strategi memilih individu yang representatif dikemukakan disini. Video Content Marketing menggali lebih dalam ke dalam pentingnya konten video, sementara Social Media Dan Pemasaran serta Social Media Strategy membahas peran media sosial dalam pemasaran digital. Bab-bab terakhir, Mobile Marketing dan Data Analytics, membahas tren terbaru dalam pemasaran digital, termasuk pemasaran mobile dan analisis big data yang mendalam, untuk membantu pemasar sukses dalam memenuhi kebutuhan dan keinginan pelanggan melebihi ekspektasi mereka.
Outra clínica, outra escola: psicanálise e educação em tempos de pandemia – Parte II
Authors: Silva Kelly Cristina Brandão da
Published: June 2024

O ineditismo imposto pela pandemia não impossibilita que uma análise aconteça, contudo impõe uma reflexão acerca da tática e da estratégia, orientadas pela política da Psicanálise, a qual, como bem indica Lacan, coincide com a sua ética. Este segundo número do Dossiê “Outra clínica, outra escola: psicanálise e educação em tempos de pandemia” reúne textos a respeito da clínica. Os autores problematizam os limites e as possibilidades de flexibilização do setting e da técnica, ao discutir o caráter inventivo das experiências com a clínica online, assim como a dimensão sociopolítica do sofrimento, sobretudo em contextos de vulnerabilidade social. Destacam-se vivências singulares que analisam o dispositivo institucional, o atendimento de crianças com impasses graves na constituição psíquica, assim como as vicissitudes do trabalho com adolescentes. Apesar dos inúmeros desafios, os psicanalistas parecem não ter recuado em tempos de pandemia e atendimentos virtuais. Esse é o testemunho dos autores que compõem esse dossiê.
Experiência com crianças e adolescentes na pandemia: alcances e limites da família, escola e clínica
Authors: Campana Nathalia Teixeira Caldas , Casella Caio Borba
Published: June 2024

Due to the COVID-19 pandemic, the counseling sessions of children and adolescents migrated from in-person to telepsychology, an unprecedented practice that required professionals to make great efforts to reflect theoretically on the possibilities of making both the setting and technique flexible. In order to enable such change, grief work was necessary. Based on vignettes, we, hereby, discuss how children and adolescents, parents and schools were presented in the clinical setting during the first months of the pandemic and how they handled the imposed changes. We highlight that, despite being immersed in the same context, the experiences were unique. Finally, we discuss the possibilities and challenges of online counseling. In the case of children, the practice revealed itself as more challenging, especially long term.
Talleres terapéuticos para niños y niñas con Trastorno del Espectro Autista: estrategias y posibilidades durante la pandemia de COVID- 19
Authors: Avila Daniel Camparo , Macias Micaela Vedovelli , Mosca Bianca , Alvez Mariana , Hontou Cecilia , Larrosa Dinorah
Published: June 2024

A chegada dos primeiros casos de COVID-19 ao Uruguai vem acompanhada do decreto de emergência sanitária. Isso interrompe o funcionamento de um dispositivo institucional para meninos e meninas com autismo, que atualmente é composto por oficinas terapêuticas coordenadas por estudantes da Faculdade de Psicologia da Universidade da República. A partir dos relatos de três grupos, seus participantes e as ações implementadas para dar continuidade ao processo terapêutico na virtualidade são brevemente descritos. A seguir, são discutidas as estratégias utilizadas a partir dos eixos continuidade do tratamento, aliança terapêutica, transferência e técnica. Por fim, são tiradas conclusões sobre a realização das oficinas na modalidade virtual como forma de promover a continuidade do atendimento clínico.
"Minha filha tem um atraso": considerações sobre uma (pseudo) deficiência intelectual e sua dinâmica familiar
Authors: Esposito Bruno , Castanho Pablo
Published: June 2024

Este artigo trabalha possibilidades de intervenção com pacientes tidos como deficientes intelectuais. Após apresentar o caso clínico, situamos a noção de deficiência intelectual, seu histórico e lugar no campo das terapêuticas. Em seguida, buscamos os aportes da psicanálise ao tema para compreender os processos psíquicos envolvidos na situação, desde a inibição intelectual até os não ditos familiares e a transmissão intergeracional do traumático. Finalmente, a teoria é articulada aos aspectos do caso. Conclui-se a importância dos psicoterapeutas e equipes de tratamento se familiarizarem com a temática, considerando a relevância dos aspectos psíquicos e relacionais nas produções sintomáticas de aprendizagem. Nos contextos institucionais de tratamento, destaca-se a importância da flexibilidade dos dispositivos clínicos, permitindo intervenções individuais, grupais e familiares, a depender do momento de tratamento.
Elas na inteligência artificial – Questões de gênero
Authors: Wassermann Renata
Published: June 2024

Há muitos anos se discute a baixa representatividade de alguns grupos nas áreas tecnológicas, principalmente mulheres e pessoas negras. Neste artigo, examinamos o caso da inteligência artificial, em que o panorama não é diferente. Discutimos os efeitos da falta de diversidade nos grupos que desenvolvem a IA e iniciativas ao redor do mundo para tentar mitigá-los. Mostramos um caso específico – sistemas de tradução automática, uma subárea da IA – em que os estereótipos de gênero aparecem.
A inteligência artificial na pesquisa agrícola
Authors: Saraiva António Mauro , Osório Fernando Santos , Colaço André Freitas , Drucker Debora Pignatari , Mendiondo Eduardo Mario , Corrêa Fernando Elias , Soares Filipi Miranda , Molin José Paulo , Benso Marcos Roberto , Marques Patricia Angélica Alves , Silva Roberto Fray da , Miranda Sílvia Helena Galvão de , Costa Willian França , Delbem Alexandre Cláudio Botazzo
Published: June 2024

A agricultura é um dos setores mais importantes da economia, fundamental para prover alimentos, fibras e energia para a humanidade. No Brasil é importante fonte de empregos e para uma balança comercial positiva. É também um dos setores que mais impactam o ambiente, pela mudança do uso do solo e pelas práticas de produção que podem resultar em poluição de solo, água e ar. Para fazer frente à complexidade dos seus processos de produção, a inteligência artificial tem desempenhado um papel cada vez mais importante na pesquisa agrícola, inovação e transformação social. Este texto aborda esse papel em algumas áreas importantes: gestão da água, produção agrícola e cadeias de valor, e a questão dos dados para a pesquisa.
System and Parody: Notes Towards a Description of Two Aspects of the Theory of Translation of Russian Formalism
Authors: Outes Cristian Cámara
Published: June 2024

In this paper, we look into the theoretical and aesthetic conceptions of Russian formalism and the way in which these were applied to the specific field of translation studies. The functions of translation are examined in the theoretical and historical-literary studies published by Víktor Shklovsky, Yuri Tynyanov and Boris Eikhenbaum between the years 1913 and 1928. As a result of this analysis, we find that two key terms in formalist considerations about translation are those of system and parody. Throughout the theoretical evolution of the school, we see the continuity of certain theoretical constants: systematic, dialectical and dynamic understanding of literary systems and a persistent discussion about the nature of the relationships between translation and writing. From this realization, the conclusion is drawn that Russian formalism has not been sufficiently assimilated by contemporary scholars working in the field of Translation Studies, and that its fundamental ideas might still exert an enriching influence on research carried out today.
Tolstói e a sexualidade feminina: uma análise das personagens femininas em Felicidade Conjugal, Anna Kariênina e A Sonata a Kreutzer
Authors: Páteo Julia Ferrari Duarte do
Published: June 2024

O tema do adultério e da sexualidade feminina perpassa boa parte da obra de Liev Tolstói, cuja visão acerca da posição da mulher na sociedade pode ser associada, também, à sua concepção de arte. Não à toa, no seu polêmico ensaio O que é a Arte? (1898), ele se vale de uma analogia com as mulheres para elucidar sua visão. Assim, pensar a figura feminina parece ser central na constituição de sua obra. Tendo isso em vista, propõe-se uma análise das principais personagens femininas de três de suas obras em que essa problemática da sexualidade feminina se faz presente, Felicidade Conjugal (1859), Anna Kariênina (1878), e A Sonata a Kreutzer (1889). Com isso, busca-se recuperar a maneira como Tolstói representava as mulheres em suas narrativas, bem como destacar as implicações dos diferentes recursos literários adotados em cada obra no que se refere às representações construídas.
Guerra e Paz: uma epopeia romanesca
Authors: Faria Marcella
Published: June 2024

O presente artigo tem como finalidade analisar a obra Guerra e paz de Liev Tolstói, publicada em 1867, especificamente as características que a torna tanto uma epopeia, quanto um romance. Também investigaram-se aspectos do romance educativo presentes nela, comparando-a com o romance Os anos de aprendizado de Wilhelm Meister, publicado pelo escritor alemão Johann Wolfgang von Goethe em 1796. Para tanto, descreveram-se os elementos da epopeia e do romance presentes em Guerra e paz. O estudo também enfoca a figura do herói criada por Tolstói, que a princípio assemelha-se ao herói homérico, mas que se transforma em um herói cristão. O resultado permitiu concluir que essa obra apresenta características dos dois gêneros literários enfocados nesta pesquisa e revela a grandeza literária de Tolstói.
Errância do cogito no jovem Tolstói: liberdade e ascese da vontade (1847–1852)
Authors: Cabral Jimmy Sudario
Published: June 2024

Errance du cogito chez le jeune Tolstoï : liberté et ascèse de la volonté (1847-1852)
Espinosa e Marx: a potência do pensamento e a inteligibilidade do real
Authors: Paula Marcos Ferreira de
Published: June 2024

Este artigo faz uma aproximação entre os pensamentos filosóficos de Karl Marx e Baruch de Espinosa. Os dois filósofos apresentam em comum um pensamento rigorosamente elaborado, e cuja potência explicativa extrapola as barreiras do tempo, colocando-se como referência obrigatória para pensar o real (tanto em seu sentido ontológico quanto em seus aspectos históricos e sociais). O cerne dessa potência explicativa contida no pensamento de ambos os filósofos estaria na adoção e colocação em prática do antigo preceito “conhecer é conhecer pela causa”. Sugere-se, por fim, que a dialética em Marx seria melhor apreendida, não pela referência hegeliana, mas pela “causalidade circular” imanente de Espinosa.
As astúcias da cumplicidade: sobre a suposta influência de Spinoza sobre Marx
Authors: Bianchi Bernardo
Published: June 2024

No presente artigo, debatemos a hipótese relativa à suposta influência de Spinoza na obra de Marx. Partindo de uma frase escrita por Althusser – “[Spinoza] é o único ancestral direto de Marx” –, buscamos demonstrar que a relação entre Spinoza e Marx não tem fundamento no nível historiográfico, mas, sobretudo, no nível das afinidades teóricas. Este argumento é confirmado através da leitura que Marx fez de Spinoza em 1841 com a refutação de Spinoza elaborada por ele em A Sagrada Família. Contrariamente ao que poderíamos esperar, quando Marx abandona sua fase mais pronunciadamente idealista, denominada kantiana-fichteana por Althusser, ele se insurge, simultaneamente, contra Spinoza. Assim, contra o spinozismo, Marx mobiliza, contudo, um arsenal de reflexões teóricas que poderia ser atribuído a Spinoza. Por uma astúcia dos encontros, é negando Spinoza que Marx se torna seu cúmplice intelectual.
One-Year Effects of High-Intensity Statin on Bioactive Lipids: Findings From the JUPITER Trial
Authors: Hoshi Rosangela Akemi , Alotaibi Mona , Liu Yanyan , Watrous Jeramie D. , Ridker Paul M , Glynn Robert J. , Serhan Charles N. , Luttmann-Gibson Heike , Moorthy M. Vinayaga , Jain Mohit , Demler Olga V. , Mora Samia
Published: June 2024

BACKGROUND:

Statin effects extend beyond low-density lipoprotein cholesterol reduction, potentially modulating the metabolism of bioactive lipids (BALs), crucial for biological signaling and inflammation. These bioactive metabolites may serve as metabolic footprints, helping uncover underlying processes linked to pleiotropic effects of statins and yielding a better understanding of their cardioprotective properties. This study aimed to investigate the impact of high-intensity statin therapy versus placebo on plasma BALs in the JUPITER trial (Justification for the Use of Statins in Prevention: an Intervention Trial Evaluating Rosuvastatin; NCT00239681), a randomized primary prevention trial involving individuals with low-density lipoprotein cholesterol <130 mg/dL and high-sensitivity C-reactive protein ≥2 mg/L.

METHODS:

Using a nontargeted mass spectrometry approach, over 11 000 lipid features were assayed from baseline and 1-year plasma samples from cardiovascular disease noncases from 2 nonoverlapping nested substudies: JUPITER
discovery
(n=589) and JUPITER
validation
(n=409). The effect of randomized allocation of rosuvastatin 20 mg versus placebo on BALs was examined by fitting a linear regression with delta values (∆=year 1−baseline) adjusted for age and baseline levels of each feature. Significant associations in discovery were analyzed in the validation cohort. Multiple comparisons were adjusted using 2-stage overall false discovery rate.

RESULTS:

We identified 610 lipid features associated with statin randomization with significant replication (overall false discovery rate, <0.05), including 26 with annotations. Statin therapy significantly increased levels of 276 features, including BALs with anti-inflammatory activity and arterial vasodilation properties. Concurrently, 334 features were significantly lowered by statin therapy, including arachidonic acid and proinflammatory and proplatelet aggregation BALs. By contrast, statin therapy reduced an eicosapentaenoic acid–derived hydroxyeicosapentaenoic acid metabolite, which may be related to impaired glucose metabolism. Additionally, we observed sex-related differences in 6 lipid metabolites and 6 unknown features.

CONCLUSIONS:

Statin allocation was significantly associated with upregulation of BALs with anti-inflammatory, antiplatelet aggregation and antioxidant properties and downregulation of BALs with proinflammatory and proplatelet aggregation activity, supporting the pleiotropic effects of statins beyond low-density lipoprotein cholesterol reduction.
Exploring T Cell Receptor Repertoires in Myocardial Diseases
Authors: Ashour DiyaaElDin , Le Gouge Kenz , Rainer Peter P. , Mariotti-Ferrandiz Encarnita , Campos Ramos Gustavo
Published: June 2024

Mounting experimental and clinical evidence has revealed that adaptive immune mechanisms targeting myocardial antigens are triggered by different forms of cardiac injury and impact disease progression. B and T lymphocytes recognize specific antigens via unique adaptive immune receptors generated through a somatic rearrangement process that generates a potential repertoire of 10
19
unique receptors. While the adaptive immune receptor repertoire diversity provides the basis for immunologic specificity, making sense of it can be a challenging task. In the present review, we discuss key aspects underlying the generation of TCRs (T cell receptors) and emerging tools for their study in the context of myocardial diseases. Moreover, we outline how exploring TCR repertoires could lead to a deeper understanding of myocardial pathophysiological principles and potentially serve as diagnostic tools.
IL-1R Mediated Activation of Renal Sensory Nerves in DOCA-Salt Hypertension
Authors: Baumann Daniel , Van Helden Dusty , Evans Louise C. , Vulchanova Lucy , Dayton Alex , Osborn John W.
Published: June 2024

BACKGROUND:

Clinical trials of renal denervation for the treatment of hypertension have shown a variety of off-target improvements in conditions associated with sympathetic overactivity. This may be due to the ablation of sympathoexcitatory afferent renal nerves, which are overactive under conditions of renal inflammation. Renal IL (interleukin)-1β is elevated in the deoxycorticosterone acetate-salt model of hypertension, and its activity may be responsible for the elevation in afferent renal nerve activity and arterial pressure.

METHODS:

Continuous blood pressure recording of deoxycorticosterone acetate-salt mice with IL-1R (IL-1 receptor) knockout or antagonism was used individually and combined with afferent renal denervation (ARDN) to assess mechanistic overlap. Protein quantification and histological analysis of kidneys were performed to characterize renal inflammation.

RESULTS:

ARDN attenuated deoxycorticosterone acetate-salt hypertension (−20±2-Δmm Hg mean arterial pressure [MAP] relative to control at study end) to a similar degree as total renal denervation (−21±2-Δmm Hg MAP), IL-1R knockout (−16±4-Δmm Hg MAP), or IL-1R antagonism (−20±3-Δmm Hg MAP). The combination of ARDN with knockout (−18±2-Δmm Hg MAP) or antagonism (−19±4-Δmm Hg MAP) did not attenuate hypertension any further than ARDN alone. IL-1R antagonism was found to have an acute depressor effect (−15±3-Δmm Hg MAP, day 10) in animals with intact renal nerves but not those with ARDN.

CONCLUSIONS:

These findings suggest that IL-1R signaling is partially responsible for the elevated afferent renal nerve activity, which stimulates central sympathetic outflow to drive deoxycorticosterone acetate-salt hypertension.
Stroke Incidence in Patients With Hypertension According to Cardiorespiratory Fitness
Authors: Kokkinos Peter , Faselis Charles , Pittaras Andreas , Samuel Immanuel Babu Henry , Lavie Carl J. , Ross Robert , LaMonte Michael , Franklin Barry A. , Grassos Charalampos , Zamrini Edward , Murphy Rayelynn , Myers Jonathan
Published: June 2024

BACKGROUND:

Hypertension and physical inactivity are risk factors for stroke. The effect of cardiorespiratory fitness (CRF) on stroke risk in patients with hypertension has not been assessed. We evaluated stroke incidence in patients with hypertension according to CRF and changes in CRF.

METHODS:

We included 483 379 patients with hypertension (mean age±SD; 59.4±9.0 years) and no evidence of unstable cardiovascular disease as indicated by a standardized exercise treadmill test. Patients were assigned to 5 age- and sex-specific CRF categories based on peak metabolic equivalents achieved at the initial exercise treadmill test and in 4 categories based on metabolic equivalent changes over time (n=110 576). Multivariable Cox models, adjusted for age, and comorbidities were used to estimate hazard ratios and 95% CIs for stroke risk.

RESULTS:

During a median follow-up of 10.6 (interquartile range, 6.6–14.6) years, 15 925 patients developed stroke with an average yearly rate of 3.1 events/1000 person-years. Stroke risk declined progressively with higher CRF and was 55% lower for the High-fit individuals (hazard ratio, 0.45 [95% CI, 0.42–0.48]) compared with the Least-fit. Similar associations were observed across the race, sex, and age spectra. Poor CRF was the strongest predictor of stroke risk of all comorbidities studied (hazard ratio, 2.24 [95% CI, 2.10–2.40]). Changes in CRF reflected inverse and proportional changes in stroke risk.

CONCLUSIONS:

Poor CRF carried a greater risk than any of the cardiac risk factors in patients with hypertension, regardless of age, race, or sex. The lower stroke risk associated with improved CRF suggests that increasing physical activity, even later in life, may reduce stroke risk.