bluuebunny/crossref_metadata_2025 huggingface dataset:
Occupational perceptions of physiotherapists and physiotherapy students in Turkey: A comparative study
Authors: Alaca Nuray , Karakuş Meryem Bektaş , Kocaer Özge , Arslan Dilek Çağrı
Published: July 2023

BACKGROUND: The social position, perceived prestige and image of a profession are often of interest to members of that profession, and physiotherapy is no exception. OBJECTIVE: The aim of this study was to examine the perceived occupational prestige and image of physiotherapists and physiotherapy students in Turkey. METHODS: 235 physiotherapy students and 465 physiotherapists were included in the study. A survey questioning occupational image, job satisfaction and prestige of the profession according to eight occupations was completed by the participants online. RESULTS: In terms of prestige, physiotherapy students ranked their profession fourth among eight undergraduate professions, while physiotherapists ranked their profession fifth. Compared to physiotherapists, physiotherapy students had more positive perceptions about their children becoming physiotherapists, the image of the profession in the eyes of the society, and job satisfaction (p < 0.05). Professional expectations of physiotherapists were higher than students. In addition, physiotherapists working for more than ten years had more positive perceptions about their children becoming physiotherapists, the public image of the profession, income level, and social standing, although perceived job satisfaction and need status were lower compared to physiotherapists with less than ten years of experience (p < 0.05). CONCLUSION: While physiotherapy students in Turkey perceived the prestige of the physiotherapist profession at a moderate level compared to other undergraduate professions, physiotherapists had a slightly lower perception of professional prestige compared to students. More comprehensive studies are needed on this subject.
Stickies Control With Cyclodextrins
Authors: BANERJEE SUJIT , HAYNES R. DANIEL
Published: July 2023

Cyclodextrins (CDs) are cyclic structures consisting of six to eight glucose units. Laboratory work showed that they can dramatically reduce the tack of stickies and also inhibit the tendency of microstickies to agglomerate and deposit out. Contact angle measurements showed that CDs increase the hydrophilicity of PSA films, making them more wettable. CDs can also reduce the tack of pitch components but to a lesser extent. Two trials with β-CD at a newsprint mill confirmed its ability to reduce the tack of filtrate components. Surprisingly, β-CD is effective only at a low dose; increasing the dose reverses the benefit.
Lesiones térmicas recurrentes en piel acral tras exposición a temperaturas bajas. Reporte de caso
Authors: Robles Delgado María Cristina , Moreno Dávila Ana Patricia , Sarango Feijoó Angie Carolina
Published: July 2023

Introducción. El eritema pernio es una condición que se presenta como una reacción anormal a temperaturas bajas, debida a una prolongada vasoconstricción la cual conlleva a una inflamación e hipoxemia de las paredes vasculares; generalmente se presenta en países con climas muy fríos. La enfermedad fue descrita por primera vez por William Tomas en 1894 denominándola como “dermatitis hiemalis”. El mayor número de casos fue reportado durante la segunda guerra mundial. Objetivo. Conocer los principales hallazgos de la evolución clínica y diagnóstico de sabañones, con la finalidad de que sirva de aporte a la comunidad científica médica. Metodología.  Se empleó el reporte de caso clínico en relación a Sabañones, mediante la recolección retrospectiva de la información por acceso a la historia clínica por medio de la autorización de la paciente a través del consentimiento informado. Se incluye una revisión bibliográfica para corroborar la información del caso. Resultados. Paciente femenina de 21 años acude a consulta externa de Dermatología en la cual refiere que desde hace 5 años presenta manifestaciones dermatológicas recurrentes en manos y pies, posterior a varios tratamientos que no recuerda, presentó leve mejoría y varios episodios de remisión y exacerbación. Al examen físico presenta máculas violáceas y pápulas eritematosas de 1 mm sobre eritema, distribuidas bilateralmente en falanges distales de dedos de las manos y de los pies, mientras que, en el dorso de manos, en palmas y plantas presenta escasas pápulas eritematosas, algunas de ellas ulceradas.  Conclusión.  Al ser una enfermedad infrecuente en nuestro medio no suele ser diagnosticada de manera oportuna y por ende es tratada ineficazmente, empeorando así los cuadros clínicos de los pacientes e incluso poniendo en riesgo su vida. Con la presentación de este caso se espera el aporte a la comunidad científica para conocer a mayor profundidad el manejo del pernio.
Evaluasi Penurunan Oprit Pada Salah Satu Proyek Jembatan di Kalimantan Tengah
Authors: Shodiq Achmad Fajar , Putra Paksitya Purnama , Wicaksono Luthfi Amri
Published: July 2023

Salah satu proyek pembangunan jembatan di Kalimantan dibangun di atas tanah lunak dengan menggunakan sistem perkuatan piled embankment. Perkuatan yang digunakan adalah gabungan antara tiang-tiang minipile dan geotextile. Namun setelah dilaksanakan penimbunan tanah pada oprit jembatan, terjadi penurunan kurang lebih sebesar 0,6 m dalam kurun waktu 3 bulan. Studi dilakukan untuk mengevaluasi dan meninjau penyebab penurunan. Selain itu dilakukan optimalisasi rancangan pada studi ini. Evaluasi dilakukan dengan meninjau kapasitas daya dukung tiang tunggal dan kelompok tiang dari minipile berdasarkan hasil pengujian lapangan SPT. Perhitungan distribusi beban pada piled embankment mengikuti aturan BS 8006. Analisis deformasi dilakukan dengan program bantu Plaxis 2D. Berdasarkan hasil analisa didapatkan nilai daya dukung ultimate kelompok tiang di bawah timbunan tidak mampu menahan beban yang bekerja. Besar kemungkinan penurunan yang terjadi pada oprit jembatan disebabkan oleh keruntuhan tanah. Berdasarkan analisa penurunan menggunakan program plaxis didapatkan nilai sebesar 0,6 m dalam kurun waktu 90 hari. Berdasarkan hasil evaluasi, optimalisasi rancangan dilakukan dengan menggunakan metode yang sama yakni menggunakan pile embankment namun berbeda pada dimensi dan konfigurasi pemasangan. Hasil optimalisasi rancangan menunjukkan nilai daya dukung yang menenuhi serta deformasi total rata-rata yang dihasilkan adalah sebesar 0,0435 m.
Evaluasi Efektivitas Layanan Pada Jalan Tol Balikpapan-Samarinda Dalam Memenuhi Kepuasan Pengguna
Authors: Rezky Zsagheta Ihwal , Hajji Apif Miptahul , Siswanto Henri
Published: July 2023

Pembangunan jalan tol bertujuan untuk mempercepat sarana transportasi, pariwisata dan pertumbuhan ekonomi serta mempersingkat jarak waktu tempuh. Demi mendukung terlaksananya tujuan tersebut ditetapkan standar pelayanan minimal (SPM) jalan tol. Penelitian ini bertujuan menilai seberapa efektif layanan Jalan Tol Balikpapan-Samarinda dalam memenuhi kepuasan pengguna. Terdapat 30 indikator layanan Jalan Tol Balikpapan-Samarinda berdasarkan SPM jalan tol yang diukur untuk melihat tingkat kepuasan pengguna. Ketiga puluh indikator layanan tersebut mewakili lima dimensi Servqual yakni tangible, reliability, responsiveness, assurance, dan emphaty. Metode yang digunakan dalam mengukur kepuasan pengguna yaitu Customer Satisfaction Index (CSI) dan Important Perfomance Analysis (IPA) serta menggunakan analisis Strength, Weaknesses, Opportunity, Threat (SWOT). Berdasarkan hasil analisis data penelitian, diperoleh hasil simpulan (1) Berdasarkan metode CSI nilai indeks kepuasan pengguna jasa diperoleh sebesar 74.11 % yang masuk kriteria puas. (2) Berdasarkan metode IPA,  ada 7 indikator layanan yang termasuk dalam kuadran I, dimana frekuensi indikator layanan tidak lebih dari (1/4) 30 indikator layanan yaitu 8 indikator, mengindikasikan layanan efektif dalam memenuhi kepuasan pengguna. (3) Berdasarkan analisis SWOT menghasilkan matriks yang mencakup tiga strategi SO, dua strategi ST, dua strategi WO dan tiga strategi WT, dimana strategi terbaik yang dapat diterapkan yaitu strategi  WT.
The structure, conduct, and performance of the hatchery segment of the aquaculture value chain in Bangladesh
Authors: Ali Hazrat , Belton Ben , Haque Mohammad Mahfujul , Murshed-e-Jahan Khondker , Ignowski Liz
Published: July 2023

Introduction

Seed production has experienced significant growth in Bangladesh over the last decade, driven by the increasing number of hatcheries. The hatchery segment plays a crucial role in the overall growth and development of aquaculture in the country. Understanding its structure, conduct and performance is essential for assessing its impact on the productivity and profitability of aquaculture farms. However, there is a limited number of methodologically rigorous studies focusing on the hatchery segment in Bangladesh. The study aimed to fill the gap in the exiting literature by conducting a methodologically analysis of the hatchery segment of aquaculture value chain in Bangladesh.

Methods

This study was conducted in seven of the main aquaculture producing districts in southern Bangladesh. A comprehensive structured survey was conducted between May and August 2022 with 66 enterprises, including 42 carp+catfish, 16 tilapia, and 8 crustacean hatcheries.

Results and discussion

The major findings and their implications are as follows. (1) The number of hatcheries increased by 15% over the past decade, with a 27% increase in fish hatcheries and a 47% decrease in crustacean hatcheries. (2) Carp and tiger shrimp were the most commonly produced fish and crustacean seeds, contributing 67% and 99% of volume and 66% and 97% of sales value, respectively. (3) The hatcheries were family-owned and operated enterprise, and generated a total 2,491 full time equivalent (FTE) jobs. (4) Hatcheries used 86% of their broodstock annually and replaced them regularly for improving quality and avoiding inbreeding. (5) 18% of hatcheries reported facing diseases and/or water quality problems, but mean economic loss was only 0.71% of seed sales value, which is a low level of loss and waste. (6) Average annual net profit margin was relatively modest, averaging 54% of the gross revenue, which suggests the existence of competitive seed production and marketing. The results showed that the hatchery segment in southern Bangladesh appears to be dynamic, well developed, efficient, and relatively competitive.
Influence of the starting day of luteal phase stimulation on double stimulation cycles
Authors: Fuentes Ana , García-Ajofrín Cristina , Romero Ruth , Castillo Juan Carlos , Ortíz Jose A. , Hortal Mónica , Guerrero Jaime , Bernabeu Andrea , Bernabeu Rafael
Published: July 2023

Background

Double ovarian stimulation is one of the most used strategies in poor-prognosis patients. There is a high heterogeneity between the studies regarding the execution of this stimulation protocol. The aim of this study was to investigate whether the day on which luteal phase stimulation begins after the first oocyte retrieval affects ovarian response in DuoStim cycles.

Methods

This observational and retrospective study included 541 DuoStim cycles between January 2018 and December 2021 in a private fertility clinic. Patients were assigned to 4 groups according to the timing of the onset of luteal phase stimulation after oocyte retrieval (0-2ndday, 3rdday, 4thday and 5th-6thday). The primary outcome was the number of oocytes retrieved in the luteal phase in each group.

Results

No differences were found between groups in the number of oocytes collected (5.12 ± 3.56 vs. 5.39 ± 3.74 vs. 5.61 ± 3.94 vs. 5.89 ± 3.92; p=0,6), MII or number of follicles. An increase in the duration of stimulation was found when stimulation started on the 4thday (10.42 ± 2.31 vs. 10.68 ± 2.37 vs. 11.27 ± 2.40 vs. 10.65 ± 2.37 days, p=0,033). A lower number of fertilized oocytes was observed when stimulation began before the fourth day (3.36 ± 2.80 vs. 3.95 ± 2.53 vs. 4.03 ± 2.73 vs. 4.48 ± 3.11; p=0,036). The number of blastocysts was higher when the stimulation started 5-6 days after retrieval (1.82 ± 1.74 vs. 2.13 ± 1.61 vs. 2.33 ± 2.06 vs. 2.91 ± 2.39; p= 0,030).

Discussion

The number of oocytes retrieved does not differ depending on the day that stimulation begins. However, oocytes competence in terms of fertilized oocytes and blastulation, appears to be lower when the second stimulation starts before the fourth day after oocyte retrieval.
Sequential change in olfaction and (non) motor symptoms: the difference between anosmia and non-anosmia in Parkinson’s disease
Authors: Fang Ting-Chun , Tsai Yu-Shan , Chang Ming-Hong
Published: July 2023

Introduction

Hyposmia is a common prodrome in patients with Parkinson’s disease (PD). This study investigates whether olfactory changes in PD differ according to the degree of olfactory dysfunction and whether there are changes in motor and non-motor symptoms.

Methods

The 129 subjects with PD were divided into two groups: anosmia and non-anosmia. All cases were reassessed within 1–3 years after the initial assessment. The assessment included the MDS-Unified PD Rating Scale (MDS-UPDRS), the University of Pennsylvania Smell Identification Test (UPSIT), Beck’s Depression Inventory-II (BDI-II), Montreal Cognitive Assessment (MoCA), and equivalence dose of daily levodopa (LEDD). The generalized estimating equation (GEE) model with an exchangeable correlation structure was used to analyze the change in baseline and follow-up tracking and the disparity in change between these two groups.

Results

The anosmia group was older and had a longer disease duration than the non-anosmia group. There was a significant decrease in UPSIT after follow-up in the non-anosmia group (β = −3.62, p < 0.001) and a significant difference in the change between the two groups (group-by-time effect, β = 4.03, p < 0.001). In the third part of the UPDRS motor scores, there was a tendency to increase the score in the non-anosmia group compared to the anosmia group (group-by-time effect, β = −4.2, p < 0.038). There was no significant difference in the group-by-time effect for UPDRS total score, LEDD, BDI-II, and MoCA scores.

Discussion

In conclusion, this study found that olfactory sensation may still regress in PD with a shorter disease course without anosmia, but it remains stable in the anosmia group. Such a decline in olfaction may not be related to cognitive status but may be associated with motor progression.
A weighted quantile sum regression with penalized weights and two indices
Authors: Renzetti Stefano , Gennings Chris , Calza Stefano
Published: July 2023

Background

New statistical methodologies were developed in the last decade to face the challenges of estimating the effects of exposure to multiple chemicals. Weighted Quantile Sum (WQS) regression is a recent statistical method that allows estimating a mixture effect associated with a specific health effect and identifying the components that characterize the mixture effect.

Objectives

In this study, we propose an extension of WQS regression that estimates two mixture effects of chemicals on a health outcome in the same model through the inclusion of two indices, one in the positive direction and one in the negative direction, with the introduction of a penalization term.

Methods

To evaluate the performance of this new model we performed both a simulation study and a real case study where we assessed the effects of nutrients on obesity among adults using the National Health and Nutrition Examination Survey (NHANES) data.

Results

The method showed good performance in estimating both the regression parameter and the weights associated with the single elements when the penalized term was set equal to the magnitude of the Akaike information criterion of the unpenalized WQS regression. The two indices further helped to give a better estimate of the parameters [Positive direction Median Error (PME): 0.022; Negative direction Median Error (NME): −0.044] compared to the standard WQS without the penalization term (PME: −0.227; NME: 0.215). In the case study, WQS with two indices was able to find a significant effect of nutrients on obesity in both directions identifying sodium and magnesium as the main actors in the positive and negative association, respectively.

Discussion

Through this work, we introduced an extension of WQS regression that improved the accuracy of the parameter estimates when considering a mixture of elements that can have both a protective and a harmful effect on the outcome; and the advantage of adding a penalization term when estimating the weights.
Surfactant-free self-assembled mesoscale structures in multicomponent mixtures comprising solids, liquids, and gases: nanoparticles, nanodroplets, and nanobubbles
Authors: Sedlák Marián
Published: July 2023

This mini review critically discusses self-assembled mesoscale structures (dimensions between molecular and macroscopic) forming in multicomponent mixtures comprising 1) liquids or 2) liquids and solids or 3) liquids and gases. The common feature of the discussed structures is absence of surfactants. Covered are solvophobicity-driven mesoscale structures (including metastable ouzo-type particles with finite lifetimes), surfactant-free microemulsions, and bulk nanobubbles. The emphasis is mainly on critical analysis of experimental data and suitability of available experimental methods with focus on unambiguous differentiation between various types of mesoscale structures.
Embodiment of virtual feet correlates with motor performance in a target-stepping task: a pilot study
Authors: Berg Alex van den , Vries Bart de , Breedveld Zoë , Mierlo Annelouk van , Tijhuis Marnix , Marchal-Crespo Laura
Published: July 2023

Immersive Virtual Reality (IVR) has gained popularity in neurorehabilitation for its potential to increase patients’ motivation and engagement. A crucial yet relatively unexplored aspect of IVR interfaces is the patients’ representation in the virtual world, such as with an avatar. A higher level of embodiment over avatars has been shown to enhance motor performance during upper limb training and has the potential to be employed to enhance neurorehabilitation. However, the relationship between avatar embodiment and gait performance remains unexplored. In this work, we present the results of a pilot study with 12 healthy young participants that evaluates the effect of different virtual lower limb representations on foot placement accuracy while stepping over a trail of 16 virtual targets. We compared three levels of virtual representation: i) a full-body avatar, ii) only feet, and iii) no representation. Full-body tracking is computed using standard VR trackers to synchronize the avatar with the participants’ motions. Foot placement accuracy is measured as the distance between the foot’s center of mass and the center of the selected virtual target. Additionally, we evaluated the level of embodiment over each virtual representation through a questionnaire. Our findings indicate that foot placement accuracy increases with some form of virtual representation, either full-body or foot, compared to having no virtual representation. However, the foot and full-body representations do not show significant differences in accuracy. Importantly, we found a negative correlation between the level of embodiment of the foot representation and the distance between the placed foot and the target. However, no such correlation was found for the full-body representation. Our results highlight the importance of embodying a virtual representation of the foot when performing a task that requires accurate foot placement. However, showing a full-body avatar does not appear to further enhance accuracy. Moreover, our results suggest that the level of embodiment of the virtual feet might modulate motor performance in this stepping task. This work motivates future research on the effect of embodiment over virtual representations on motor control to be exploited for IVR gait rehabilitation.
Hydrogen Production from Gelatin, Cotton, Wheat Straw, and Sour Cabbage and Their Mixtures—Short Communication
Authors: Sołowski Gaweł , Shalaby Marwa S. , Ozdemir Fethi Ahmet
Published: July 2023

The influence of microaeration, pH, and substrate during dark fermentation of sour cabbage, gelatin, and wheat straw was investigated, and the results of dark fermentation of these three substrates and their mixtures are presented in this research. The fermentation of cabbage, gelatin, and wheat straw was investigated under varying pH and aeration conditions. We investigated concentrations of volatile suspended solids (VSS) of 20 g VSS/L of a substrate at a stable pH of 6.0 and a not aligned pH value. Sour cabbage resulted in the highest volume of hydrogen for 450 mL/g VSS with a pH of 6.0. The mixing of substrates caused lower hydrogen production than sour cabbage or wheat straw alone.
Effects of Changing Restoration Years on Soil Nutrient Traits and Plant Community Diversity in a Phosphate Mining Area
Authors: Xu Cui , Kuang Siping , He Lu , Wang Chunxue , Zu Yanqun
Published: July 2023

The thinning vegetation and soil erosion problems left behind by extractive mining have caused serious environmental pollution, and vegetation restoration is one of the effective strategies to counter them. To study the effects of vegetation restoration on plant community species diversity, soil carbon, nitrogen and phosphorus, and the response of their plant community succession, four communities of different ages (1, 7, 10, 40) and one natural forest (>50 years) in the Kunyang phosphate mine were selected, and the analysis was carried out using the methods and protocols for plant community inventory. The species composition was recorded, and soil was collected from 0–60 cm in each community to determine the response of soil nutrients and plant diversity to the restoration process. The results show that the species richness of the community increases with the restoration year, the species composition at 40 years of restoration is similar to that of the natural forest, and the Shannon–Wiener diversity index in the tree layer at 40 years of restoration is greater than in the natural forest. Soil pH showed a decreasing trend with restoration year, and TP and AP increased with increasing time series. And the linear stepwise regression analysis showed that soil pH, soil organic carbon (SOC), total phosphorous (TP), available phosphorous (AP), and restoration year were the main factors of plant diversity. Compared to restoration of 10 years, TP and AP at the restoration of 40 years increased to 11.9–20.0 g∙kg−1 and 33.4–75.5 mg∙kg−1. The SOC of the community reached a maximum at 40 years of restoration, 1.5, 2.8, and 2.4 times higher at 0–20 cm, 20–40, and 40–60 cm, respectively, than at 1 year. The organic carbon fraction increased with the restoration year in an ‘N’ pattern, and mineral-associated organic carbon (MOC) and unstable organic carbon fraction decreased at 10 years and 40 years of restoration. The SOC of natural forests decreased, but stable organic carbon increased. The soil pH, SOC, and organic carbon fraction of the communities decreased with increasing soil depth, while TP and AP increased with increasing soil depth at the later period of restoration. In general, with extended restoration years, 40 years plant of restoration in phosphate mines can be expected to allow for plant community succession to climax community, and the key influence on plant diversity are the phosphorus and stable carbon fractions. These results are expected to facilitate the future basis for vegetation succession and restore systems during mining area restoration.
A Research Translation, Implementation and Impact Strategy for the Australian Healthy Environments and Lives (HEAL) Research Network
Authors: Lyne Katrina , Williams Carmel , Vardoulakis Sotiris , Matthews Veronica , Farrant Brad , Butt Andrew , Walker Iain , Chu Cordia , Dennekamp Martine , Espinoza Oyarce Daniela , Ivers Rebecca , Jalaludin Bin , Jones Penelope , Martin Karina , Rychetnik Lucie
Published: July 2023

Healthy Environments And Lives (HEAL) is the Australian national research network established to support improvements to health, the Australian health system, and the environment in response to the unfolding climate crisis. The HEAL Network comprises researchers, community members and organisations, policymakers, practitioners, service providers, and other stakeholders from diverse backgrounds and sectors. HEAL seeks to protect and improve public health, reduce health inequities and inequalities, and strengthen health system sustainability and resilience in the face of environmental and climate change, all with a commitment to building on the strengths, knowledge, wisdom, and experience of Aboriginal and Torres Strait Islander people, culture, and communities. Supporting applied research that can inform policy and practice, and effective research translation, implementation, and impact are important goals across the HEAL Network and essential to achieve its intended outcomes. To aid translation approaches, a research translation, implementation, and impact strategy for the HEAL Network was developed. The strategy has been created to inform and guide research translation across HEAL, emphasising communication, trust, partnerships, and co-design with communities and community organisations as well as the decision-makers responsible for public policies and programs. Development of the strategy was guided by research translation theory and practice and the Health in All Policies and Environment in All Policies frameworks. As described in this paper, the strategy is underpinned by a set of principles and outlines preliminary actions which will be further expanded over the course of the HEAL Network’s activities. Through these actions, the HEAL Network is well-positioned to ensure successful research translation and implementation across its program of work.
Combined Tumor-Based BRCA1/2 and TP53 Mutation Testing in Ovarian Cancer
Authors: Borcoman Edith , Santana dos Santos Elizabeth , Genestie Catherine , Pautier Patricia , Lacroix Ludovic , Caputo Sandrine M. , Cabaret Odile , Guillaud-Bataille Marine , Michels Judith , Auguste Aurelie , Leary Alexandra , Rouleau Etienne
Published: July 2023

Somatic/germline BRCA1/2 mutations (m)/(likely) pathogenic variants (PV) (s/gBRCAm) remain the best predictive biomarker for PARP inhibitor efficacy. As >95% of high-grade serous ovarian cancers (HGSOC) have a somatic TP53m, combined tumor-based BRCA1/2 (tBRCA) and TP53 mutation testing (tBRCA/TP53m) may improve the quality of results in somatic BRCAm identification and interpretation of the ‘second hit’ event, i.e., loss of heterozygosity (LOH). A total of 237 patients with HGSOC underwent tBRCA/TP53m testing. The ratio of allelic fractions (AFs) for tBRCA/TP53m was calculated to estimate the proportion of cells carrying BRCAm and to infer LOH. Among the 142/237 gBRCA results, 16.2% demonstrated a pathogenic/deleterious variant (DEL) gBRCA1/2m. Among the 195 contributive tumor samples, 43 DEL of tBRCAm (22.1%) were identified (23 gBRCAm and 20 sBRCAm) with LOH identified in 37/41 conclusive samples. The median AF of TP53m was 0.52 (0.01–0.93), confirming huge variability in tumor cellularity. Initially, three samples were considered as wild type with <10% cellularity. However, additional testing detected a very low AF (<0.05) in both BRCA1/2m and TP53m, thus reidentifying them as sBRCA1/2m. Combined tBRCA/TP53m testing is rapid, sensitive, and identifies somatic and germline BRCA1/2m. AF TP53m is essential for interpreting sBRCA1/2m in low-cellularity samples and provides indirect evidence for LOH as the ‘second hit’ of BRCA1/2-related tumorigenesis.
High-Intensity Interval Training Improves Glycemic Control, Cellular Apoptosis, and Oxidative Stress of Type 2 Diabetic Patients
Authors: Al-Rawaf Hadeel A. , Gabr Sami A. , Iqbal Amir , Alghadir Ahmad H.
Published: July 2023

Background and Objectives: Physical exercise is an important therapeutic modality for treating and managing diabetes. High-intensity interval training (HIIT) is considered one of the best non-drug strategies for preventing and treating type 2 diabetes mellitus (T2DM) by improving mitochondrial biogenesis and function. This study aimed to determine the effects of 12 weeks of HIIT training on the expression of tumor suppressor protein-p53, mitochondrial cytochrome c oxidase (COX), and oxidative stress in patients with T2DM. Methods: A total of thirty male sedentary patients aged (45–60 years) were diagnosed with established T2DM for more than five years. Twenty healthy volunteers, age- and sex-matched, were included in this study. Both patients and control subjects participated in the HIIT program for 12 weeks. Glycemic control variables including p53 (U/mL), COX (ng/mL), total antioxidant capacity (TAC, nmole/µL), 8-hydroxy-2′-deoxyguanosine (8-OHdG, ng/mL), as well as genomic and mitochondrial DNA content were measured in both the serum and muscle tissues of control and patient groups following exercise training. Results: There were significant improvements in fasting glucose levels. HbA1c (%), HOMA-IR (mUmmol/L2), fasting insulin (µU/mL), and C-peptide (ng/mL) were reported in T2DM and healthy controls. A significant decrease was also observed in p53 protein levels. COX, 8-OhdG, and an increase in the level of TAC were reported in T2DM following 12 weeks of HIIT exercise. Before and after exercise, p53; COX, mt-DNA content, TAC, and 8-OhdG showed an association with diabetic control parameters such as fasting glucose (FG), glycated hemoglobin (HbA1C, %), C-peptide, fasting insulin (FI), and homeostatic model assessment for insulin resistance (HOMA-IR) in patients with T2DM. These findings support the positive impact of HIIT exercise in improving regulation of mitochondrial biogenesis and subsequent control of diabetes through anti-apoptotic and anti-oxidative pathways. Conclusions: A 12-week HIIT program significantly improves diabetes by reducing insulin resistance; regulating mitochondrial biogenesis; and decreasing oxidative stress capacity among patients and healthy controls. Also; p53 protein expression; COX; 8-OhdG; and TAC and mt-DNA content were shown to be associated with T2DM before and after exercise training.
X-Intersected Silicon Modulator of Well-Rounded Performance
Authors: Zhu Zijian , Zhao Yingxuan , Sheng Zhen , Gan Fuwan
Published: July 2023

In silicon modulator design, implantation is always a key factor, significantly influencing the doping profile and carrier distribution. As waveguide doping is limited by the compact footprint of the modulator rib, three-dimensional complex optimization is a viable option to improve performance. This work proposes an X-intersected modulator based on two inversely slanted junctions using the effective 3D Monte Carlo method for junction generation. The optimized results show that the modulation efficiency of the design is 1.09 V·cm, while the loss is 18 dB/cm, and the 3 dB bandwidth reaches over 35 GHz owing to the decreased resistance and capacitance of the 3D junction. This work demonstrates the benefits of 3D doping design in silicon modulators, contributing to higher efficiency and avoiding additional PN overlap to introduce lower capacitance. The design of 3D doping profiles well balances the DC and AC performance, and provides novel modulator solutions for high-speed datacom.
NUP98 Rearrangements in AML: Molecular Mechanisms and Clinical Implications
Authors: Mohanty Sagarajit
Published: July 2023

NUP98 fusions constitute a small subgroup of AML patients and remain a high-risk AML subtype. There are approximately 30 types of NUP98 fusions identified in AML patients. These patients show resistance to currently available therapies and poor clinical outcomes. NUP98 fusions with different fusion partners have oncogenic transformation potential. This review describes how the NUP98 gene acquires oncogenic properties after rearrangement with multiple partners. In the mechanistic part, the formation of nuclear bodies and dysregulation of the HoxA/Meis1 pathway are highlighted. This review also discusses mutational signatures among NUP98 fusions and their significance in leukemogenesis. It also discusses the clinical implications of NUP98 fusions and their associated mutations in AML patients. Furthermore, it highlights therapeutic vulnerabilities in these leukemias that can be exploited as therapeutic strategies. Lastly, this review discusses the gaps in our knowledge regarding NUP98 fusions in AML, as well as future research opportunities.
Composition of Probabilistic Preferences in Multicriteria Problems with Variables Measured in Likert Scales and Fitted by Empirical Distributions
Authors: Gavião Luiz Octávio , Sant’Anna Annibal Parracho , Lima Gilson Brito Alves , Garcia Pauli Adriano de Almada
Published: July 2023

The aim of this article is to demonstrate the advantages of the Composition of Probabilistic Preferences method in multicriteria problems with data from Likert scales. Multicriteria decision aids require a database as a decision matrix, in which two or more alternatives are evaluated according to two or more variables selected as decision criteria. Several problems of this nature use measures by Likert scales. Depending on the method, parameters from these data (e.g., means, modes or medians) are required for calculations. This parameterization of data in ordinal scales has fueled controversy for decades between authors who favor mathematical/statistical rigor and argue against the procedure, stating that ordinal scales should not be parameterized, and scientists from other areas who have shown gains from the process that compensates for this relaxation. The Composition of Probabilistic Preferences can allay the protests raised and obtain more accurate results than descriptive statistics or parametric models can bring. The proposed algorithm in R-code involves the use of probabilities with empirical distributions and fitting histograms of data measured by Likert scales. Two case studies with simulated datasets having peculiar characteristics and a real case illustrate the advantages of the Composition of Probabilistic Preferences.
Solitary Solutions for the Stochastic Fokas System Found in Monomode Optical Fibers
Authors: Mohammed Wael W. , Al-Askar Farah M. , Cesarano Clemente
Published: July 2023

The stochastic Fokas system (SFS), driven by multiplicative noise in the Itô sense, was investigated in this study. Novel trigonometric, rational, hyperbolic, and elliptic stochastic solutions are found using a modified mapping method. Because the Fokas system is used to explain nonlinear pulse propagation in monomode optical fibers, the solutions provided may be utilized to analyze a broad range of critical physical phenomena. In order to explain the impacts of multiplicative noise, the dynamic performances of the different found solutions are illustrated using 3D and 2D curves. We conclude that multiplicative noise eliminates the symmetry of the solutions of the SFS and stabilizes them.
Real-Time Surveillance of Dog Bite Incidence in Islamabad: A Cross-Sectional Study from December 2019 to July 2020
Authors: Rehman Shafiq ur , Iqbal Moin , Ali Wajiha Waqar , Malik Muhammad Wasif , Ali Zulfiqar , Khan Mumtaz Ali , Ansari Jamil Ahmed , Ranjha Muazam Abbas , Bailey Emily S. , Ikram Aamer
Published: July 2023

Rabies is a neglected viral zoonotic disease with an almost 100% fatality rate. A pilot project was initiated by the National Institute of Health (NIH), Islamabad, in collaboration with Health Security Partners (HSP) to establish a real-time dog bite surveillance in humans in public sector secondary care hospitals of Islamabad. The main objective of this study was to analyze different characteristics of dog bite cases, identify gaps in surveillance, and recommend suggestions to improve and strengthen real-time dog bite surveillance systems. An observational cross-sectional study was conducted in two major public sector hospitals in Islamabad from December 2019 to July 2020. Data on demographic information, site of the dog bite, category of the dog bite, and treatment was collected via a WVS mobile-based application. Descriptive analysis was carried out for different variables at a p-value of <0.05. A total of 338 dog bite cases were captured in the World Veterinary Service (WVS) application, and most cases (n = 226, 85.6%) were reported in December 2019 with a male-to-female ratio of 2:1. Most cases were reported from the age group of 22 to 31 years (n = 178, 53%). Out of the total number of cases, 263 (78%) presented with a single anatomical location, and 174 (51%) had Category II wounds. All dog bite patients were given only the first dose of the anti-rabies vaccine at the hospital level. Real-time dog bite surveillance via a mobile-based application proved to be effective for the timely recording and management of dog bite cases. Young people were reported to be mostly affected by dog bites, and nearly half of the cases were managed in hospitals. Refresher training was conducted for medics and paramedics for mobile-based applications, dog bite management, and proper referral of cases to tertiary care hospitals.
Nonpodocyte Roles of APOL1 Variants: An Evolving Paradigm
Authors: Pell John , Nagata Soichiro , Menon Madhav C.
Published: July 2023

Since the seminal discovery of the trypanolytic, exonic variants in apolipoprotein L1 (APOL1) and their association with kidney disease in individuals of recent African ancestry, a wide body of research has emerged offering key insights into the mechanisms of disease. Importantly, the podocyte has become a focal point for our understanding of how risk genotype leads to disease, with activation of putative signaling pathways within the podocyte identified as playing a causal role in podocytopathy, FSGS, and progressive renal failure. However, the complete mechanism of genotype-to-phenotype progression remains incompletely understood in APOL1-risk individuals. An emerging body of evidence reports more than podocyte-intrinsic expression of APOL1 risk variants is needed for disease to manifest. This article reviews the seminal data and reports which placed the podocyte at the center of our understanding of APOL1-FSGS, as well as the evident shortcomings of this podocentric paradigm. We examine existing evidence for environmental and genetic factors that may influence disease, drawing from both clinical data and APOL1's fundamental role as an immune response gene. We also review the current body of data for APOL1's impact on nonpodocyte cells, including endothelial cells, the placenta, and immune cells in both a transplant and native setting. Finally, we discuss the implications of these emerging data and how the paradigm of disease might evolve as a result.
Vivências corporais com o futsal: Diálogos sobre intervenção social, produção de conhecimento e formação docente
Authors: Martins Rodrigo Lema del Rio , Campos Mateus Pereira , Silva Maicon Pinto da , Lima Bruno Oliveira , Alves Antônio Ribeiro , Murici Silvia Gomes , Marinho Amanda Kharolina Matos
Published: July 2023

Este artigo apresenta um relato de experiência que analisou o projeto de extensão universitária: “Vivências Corporais com o Futsal”. Este foi desenvolvido entre 2018 e 2019 no município de Miracema do Tocantins com crianças e adolescentes no contraturno escolar, sob responsabilidade do curso de Educação Física da Universidade Federal do Tocantins. A experiência é descrita e examinada com base nas narrativas dos discentes extensionistas, nas imagens e nos materiais públicos de divulgação do Projeto. Os resultados indicam que as ações desenvolvidas por meio da articulação da extensão com as dimensões do ensino e da pesquisa se revelaram como um potente recurso para a intervenção social na comunidade, para a produção do conhecimento e para a formação docente em Educação Física.  Considera-se que que houve o fortalecimento da formação profissional em Educação Física. Esse processo contextualizou o que se ensinava em “sala de aula”, relacionado diretamente com os problemas peculiares que atravessam a comunidade local. Igualmente, os desdobramentos desses temas geravam investigações no âmbito do Projeto com conhecimentos capazes de ampliar o repertório dos estudantes e de retroalimentar o ensino oferecido pela instituição.
Palavras-chave: Educação Física; Esporte; Ensino; Pesquisa; Relações Comunidade-Instituição
Corporal experiences with futsal: dialogues on social intervention, knowledge production and teacher training
Abstract:  This article presents an experience report that analyzed the university extension project: “Corporal Experiences with Futsal”. This was developed between 2018 and 2019 in Miracema do Tocantins (Tocantins State, Brazil) with children and adolescents after school hours, under the responsibility of the Physical Education course at the Federal University of Tocantins (UFT). The experience is described and examined based on the narratives of the extension students, on the images and on the public materials of the Project. The results indicate that the actions developed through the articulation of extension with the dimensions of teaching and research proved to be a powerful resource for social intervention in the community, for the production of knowledge and for teacher training in Physical Education. It is considered that there was a strengthening of professional training in Physical Education. This process contextualized what was taught in the “classroom”, directly related to the peculiar problems that cross the local community. Likewise, the unfolding of these themes generated investigations within the scope of the Project with knowledge capable of expanding the students' repertoire and providing feedback to the teaching offered by the institution.
Keywords: Physical education; Sport; Teaching; Research; Community-Institutional Relations
Karakteristik Mutu Kimia Pempek dan Potensi Cemaran Logam Berat (Pb dan Cd) di Kota Palembang
Authors: Dwijaya Oby , Lestari Susi , Hanggita Siti
Published: July 2023

The purpose of his research was to determine the chemical characteristics and the heavy metal (Pb and Cd) content on producers in Palembang. The research was conducted on February 2014 until March 2014. The results obtained in this study were analyzed using descriptive methods. Parameters observed were chemical analysis (moisture content, protein content, fat content, ash content and carbohydrate content) and analysis of heavy metals lead (Pb) and cadmium (Cd). Chemical characteristics of pempek lenjer in this study with the range of water content between 48.89%-66.92%, ash content 1.01%-5.80%, protein content 0.042%-2.027%, fat content 1.01%-1.67% and carbohydrates 22.64%-39.05%. Where as lead (Pb) < 0.0104 mg/kg was detected on concentration less than and cadmium (Cd) < 0.0006 mg/kg.
Is peperina (Minthostachys verticillata) exclusively found in South America?
Authors: Del Mastro Nelida Lucia
Published: July 2023

Medicinal plants are used since prehistoric times all around the world, particularly among native people of South America. In the present work several scientific studies are quoted that described the use of Minthostachy verticillata, or M. mollis (Lamiaceae) commonly referred to as “peperina”, a medicinal native plant, with various uses and properties, considered for many native to Argentina Northeast. Same common names can be used in different places for diverse plants, then we consider that it is not rare the appearance of misunderstanding, using the common name “peperina” meaning different plants. For that reason, the question stated at the title of this article: Is peperina (Minthostachys verticillata) exclusively found in South America?” remains without a proper and unambiguous answer worldwide.
Assessment of Acute Toxicity of Quinazoline Derivative 3-[2-oxo-2-(4-Phenylpiperazine-1-yl)Ethyl]quinazoline-4(3h)-oh Active against Opportunistic Microorganisms
Authors: Gabitova N. M. , Tsibizova A. A. , Ozerov A. A. , Samotrueva M. A.
Published: July 2023

The study is devoted to the study of acute toxicity of a new quinazoline compound — 3-[2-Oxo-2-(4-phenylpiperazine-1-yl)ethyl]quinazoline-4(3H)-one (VMA-10-21), promising as an antimicrobial agent active against opportunistic microorganisms. Purpose. Assessment of acute toxicity of the quinazoline derivative 3-[2-oxo-2-(4-phenylpiperazine-1yl)ethyl] quinazoline-4(3h)-oh, exhibiting antimicrobial activity. Material and methods. All experiments were carried out on non-linear mature female rats with a body weight of 180–190 g. Female individuals were in the diestrus stage. The rats were divided into groups (n=6) by a random sample, there were 4 individuals in each group and were kept in cages for a week before the experiment, getting used to laboratory conditions: animals receiving intragastric equiobjection of distilled water (control); experimental animals treated with the compound VMA-10-21 at doses of 1000, 2000; 5000 mg/kg (the doses were selected based on the fact that the study of the toxicity of pyrimidine derivatives with a similar chemical structure showed their relative safety and the absence of lethality from a dose of 500 mg/kg). Results. Assessment of acute toxicity of the quinazoline derivative 3-[2-oxo-2-(4-phenylpiperazine-1yl)ethyl]quinazoline-4(3h)-oh with intragastric administration showed that this compound belongs to class 5 toxicity and is low-toxic according to. Under these conditions, and for LD₅₀, the maximum dose is 5000 mg/kg. However, despite the results obtained, when this compound was administered at a dose of 5000 mg/kg, changes in hemoglobin, the number of leukocytes and platelets, as well as total protein were observed, which may indicate the possible development of pathological changes in the hematopoietic and hepatobiliary systems. Conclusion. Thus, the quinazoline derivative 3-[2-oxo-2-(4-phenylpiperazine-1yl)ethyl]quinazoline-4(3h)-oh with intragastric administration is low-toxic and belongs to the 5th class of toxicity, and therefore the maximum dose is 5000 mg/kg for LD₅₀. However, given the fact that there are changes in hematological and biochemical parameters, this compound needs to be studied in detail under the conditions of course effects on the body of animals.
Bacterial (Septic) Arthritis
Authors: Belov B. S. , Muravyeva N. V.
Published: July 2023

In modern conditions, the problem of bacterial arthritis (BA) is very relevant. The leading etiological agent of BA is Staphylococcus aureus. The frequency of deaths in BA has not changed significantly over the past 25 years and is 5-15%. The article highlights current data on the etiology, pathogenesis, clinical picture, diagnosis of BA. Indications for open surgical drainage of an infected joint are presented. The main schemes of empirical and etiotropic antibacterial therapy of BA are presented.
Nutritional Comparison of Fish Species from the Bizerte Lagoon (Mediterranean Coasts)
Authors: Ghribi Feriel , Bejaoui Safa , Ennouri Rym , Belhassen Dalya , Chetoui Imene , Fouzai Chaima , Trabelsi Wafa , Soudani Nejla , Mili Sami
Published: July 2023

The present study aimed to compare the nutritional quality of three fish species (Sparus aurata, Sarpa salpa, and Mullus barbatus) collected from the Bizerte lagoon (South Mediterranean coasts). Proximate composition, fatty acids and nutritional quality indices were determined. Results showed that the nutritional quality of the three fish follows this trend: S. aurata > S. salpa > M. barbatus. S. aurata had significantly higher protein content (16.02 ± 2.01 mg/g ww), glycogen level (1.08 ± 0.16 mg/g ww), and lipid content (8.47 ± 0.96 mg/g ww) which are rich in omega-3 fatty acids (47.34%). The Total Fatty Acid (TFA) profile of S. aurata was dominated by Polyunsaturated Fatty Acids (PUFA) (70.34 ± 0.02%), followed by monounsaturated (MUFA) (20.72 ± 0.04%) and Saturated Fatty Acids (SFA) (9.03 ± 0.01%). The use of different Nutritional Quality Indices (NQI) (n-3/n-6 ratio, PUFA/SFA, EPA+DHA, Atherogenicity (AI) and Thrombogenicity (TI) indices) confirmed that S. aurata is a good source of beneficial Fatty Acids (FA) and an excellent source of nutrients. Overall, the consumption of S. aurata over S. salpa and M. barbatus is highly recommended and can be considered as a healthy food for human consumption.