bluuebunny/crossref_metadata_2025 huggingface dataset:
Inlife, an online social support intervention for caregivers of people with dementia: effect evaluation and lessons learned in a randomised controlled trial (Preprint)
Authors: Christie Hannah , Dam Alieske Elisabeth Henrike , van Boxtel Martin Petrus Johannes , Köhler Sebastian , Verhey Frans Rochus Josef , de Vugt Marjolein Elisabeth
Published: May 2022

BACKGROUND

Informal care for persons with dementia (PwD) does not only affect the wellbeing of the primary caregiver, but it also changes their roles and interactions with the social environment. New online interventions might facilitate access to social support. Recently, an online social support platform, Inlife, was developed in the Netherlands aiming to enhance social support and positive interactions in informal support networks.

OBJECTIVE

The current study aimed to evaluate the effectiveness of Inlife for caregivers of PwD.

METHODS

A randomised controlled trial with 96 caregivers of PwD was performed. Participants were randomly assigned to the Inlife intervention or the waiting-list control group. After 16-weeks of Inlife usage, the waiting-list control group could start using Inlife. Effects were evaluated at baseline (T0), 8-weeks (T1), and 16-weeks (T2). The 16-week follow-up assessment (T2) served as the primary endpoint to evaluate the results for the primary and secondary outcome variables evaluated with online self-report questionnaires. The primary outcomes included feelings of caregiver competence and perceived social support. The secondary outcomes included received support, feelings of loneliness, psychological complaints (e.g., anxiety, stress), and quality of life.

RESULTS

No significant improvements were demonstrated for the intervention group relative to the control group on primary and secondary outcome measures. This contrasts with our qualitative findings showing the potential of Inlife to facilitate the care process in daily life. Adherence was not optimal for all Inlife users. Additional per protocol and sensitivity analysis also revealed no beneficial results for high active Inlife users or specific subgroups. Inlife users were more active when they had a larger network.

CONCLUSIONS

Researchers should be modest regarding the effectiveness of online caregiver interventions in terms of quantitative measures of well-being and quality of life. Nevertheless, online tools have the potential to facilitate the caregiver process in daily life. Lessons learned include the importance of harnessing the power of human interaction in eHealth and make use of the user’s social capital, and the need to develop research methods that can identify benefits in daily life that are ecologically valid for caregivers.

CLINICALTRIAL

Dutch trial register NTR6131, Registered on 20 October 2016.

INTERNATIONAL REGISTERED REPORT

RR2-https://doi.org/10.1186/s13063-017-2097-y
Intervention programme to reduce medication-related problems among polymedicated home-dwelling older adults (OptiMed): a pre-post multi-site pilot and feasibility study protocol (Preprint)
Authors: Pereira Filipa , Coelho Dixe Maria dos Anjos , Pereira Sónia Margarida , Meyer-Massetti Carla , Verloo Henk
Published: May 2022

BACKGROUND

Effective medication management is one of the essential preconditions for polymedicated home-dwelling older adults with multiple chronic conditions to remain at home and preserve their quality of life and autonomy.

OBJECTIVE

This study aims to explore the feasibility and acceptability of an evidence-based, multi-component, interprofessional intervention programme supported by informal caregivers to decrease medication related problems among polymedicated, home-dwelling older adults with multiple chronic conditions.

METHODS

This quasi-experimental pre-post multi-site pilot and feasibility study will use an open-label design, where participants know what they are signing up for and will take place in primary healthcare settings in Portugal and Switzerland. The research population will comprise 30 polymedicated home-dwelling adults aged 65 years old or more, at risk of medication related problems and receiving community-based healthcare.

RESULTS

Previous to a full-scale study, this pilot and feasibility study will focus on the recruitment and collaboration of participants and piloting the feasibility of the evidence-based, multi-component, interprofessional intervention programme.

CONCLUSIONS

This study will be an essential part of follow-up research programmes on the multiple roles of informal caregivers, as it will put their coordination tasks into perspective with their own needs.

CLINICALTRIAL

Swiss National Clinical Trials Portal (SNCTP) 000004654. Registered 1 November 2021, https://www.kofam.ch/en/snctp-portal/searching-for-a-clinical-trial/?sid=140048
Patient Design: The Importance Of Including Patients In Designing Healthcare (Preprint)
Authors: Meskó Bertalan , deBronkart Dave
Published: May 2022

BACKGROUND

Today, except for the commercial obstacle inserted by paywalls, patients can have access to the same healthcare online resources, studies and data as medical professionals (4). Empowered patients want to get engaged in their health or disease management.

Patient scholars have published in prestigious medical journals (7)(8)(9) , , . The #PatientsIncluded movement has led to involving patients in medical events either as speakers or co-hosts. Governments such as the one of New Zealand have started developing digital health policies featuring empowered patients.

These examples further underscore that a more patient inclusive design approach is already emerging and will inevitably be the norm. The only thing holding it back is cultural resistance, which is why we say digital health is a cultural transformation.

In the 2010s, a myriad of pharmaceutical, medical and healthcare companies started to use patient centricity as a mantra. Each claimed that their company is patient centric thus ahead of the others. Pharmaceutical company executives started making “putting patients first” part of their slogans and internal documents. A 2020 survey revealed that 85% of companies were raising their investment in patient-centric capabilities over the next 18 months (10).

OBJECTIVE

We analyzed the differences between patient centricity and patient design.

To drive this paradigm change fully into existence, we are calling for changing "patient centricity” from a relatively passive process, driven by industry’s needs, into a far more active, collaborative process driven by both parties’ needs and preferences. In short, it’s no longer viable for patient centricity to mean “We were thinking about you while we made our decisions.”

METHODS

-

RESULTS

This social movement has already progressed to where examples exist to illustrate the shift in thinking - the paradigm change. In the paper, we show multiple existing examples of patient design and how it can contibute to healthcare.

CONCLUSIONS

We are at the end of the only period in history where physicians knew important scientific facts and medical insights that patients could not. For healthcare to achieve its potential in this new era, our methods along with our paradigm must change.

To build this new world of practice and workflow we simply must engage with patients as true partners. To achieve medicine’s new potential, it must be optimized around the wants and priorities of the ultimate stakeholder - the party that has the most at stake in how it all plays out: the patient. Patient design is the approach that can make it happen.
A Research of Cybersecurity and Threats in Emerging Technologies
Authors: Kanu Ved Prakash Sah , Naiem Yusuf Ai , Prasad Sudha Shanker
Published: May 2022

Abstract: Cyber security is crucial in the information technology field in today's world. Because every piece of data is now housed online, securing data has become one of the most challenging responsibilities. The first thing that comes to mind when we think of cyber security is cyber criminals, namely hacking, which is on the rise. To tackle cybercrime, several governments and corporations are pursuing several measures. Aside from spectacular attempts, many people still have concerns about cyber security. This study focuses mostly on the issues that cyber security faces with emerging technology. It also concentrates on the most important aspects of data security, such as methods, ethics, and developments that are transforming the public's belief in cyber security. Keywords: Cyber security, cybercrime, firewall, social media, cloud computing, and hacking
Unavailability of Python Tool Which Can Perform Various Hacking Activities
Authors: Gadge Abhishek , Temkar Atharv , Shriram Pranav R. , Qadri Ahmad Raza , Choudhary Shraddha
Published: May 2022

Abstract: Multi Technique Hacking is implemented with all three functions in a single interface, that is, Http Packet Credential Harvesting, IP Spoofing and Packet Modification and There is no existing system in which all the functions have been used together. It describes how the process is done and how they go about helping their customers find and plug up security holes. The hacking process is explained, along with many of the challenges and opportunities in the field of ethical hacking. This hacking technique is done using scapy library which is a very big library with plenty of functions available for use. To understand the working of the library firstly the practice has to be done using the library and then try to implement it in the code. Ethical hacking, also known as penetration testing, penetration testing, or the red team, has become a major concern for businesses and governments. Companies are concerned about the possibility of being hacked and prospects are concerned about managing their personal information. This Paper describes how the process works and helps customers find and close security gaps. The hacking process is described with many challenges and opportunities in the field of ethical hacking Keywords: Scapy, IP Spoofing, Credential Harvesting, Packet Modification.
Peltier Air Conditioner using Peltier Effect
Authors: Maurya Satish Kumar , Shukla Mayank , Yadav Akash Kumar , Srinet Satyam Singh , Srivastava Swatika
Published: May 2022

Abstract: As we are moving towards the future the problem of global warming is emerging as one of the most important issues which concern the whole world. In recent years the world has come to a realization that if this problem is not dealt with now it will have devastating effects later. Nowadays we are experiencing the changes in the climate right before our eyes - unexpected climate change, rainfalls, Landslides, Air pollution reaching dangerous levels, melting off glaciers, Ozone Depletions, there are many such examples which are caused due to the increasing Global warming. To combat it we are switching to green infrastructure to mitigate its influence and that’s where the Peltier steps in Conventional AC make use of harmful gasses like CFC, HCFC, Ferons, R22, R410A but in the case of Peltier AC, it makes use of the intrinsic property of the Peltier chips which utilizes the Peltier effect to provide cooling. One of the most important advantages of the Peltier modules is that It doesn’t release any harmful gasses whatsoever. Peltier AC can be considered as the future of air cooling due to its advantage over its predecessors and can play a vital role in mitigating the problem which concerns the whole world. Keywords: Peltier Effect, Seebeck effect, Air conditioner, Green infrastructure, Global Warming, Peltier AC
Analysis of Friction Disc of Single Plate Clutch by using Ansys: A Review
Authors: Kataria Prashant Singh , Saini Ruchika , Joshi U. K.
Published: May 2022

Abstract: A Clutch is a machine member used to connect the driving shaft to a driven shaft, so that the driven shaft may be started or stopped at will, without stopping the driving shaft. A clutch thus provides an interruptible connection between two rotating shafts. The present used material for friction disc is Grey Cast Iron, Sintered Iron, Kevlar, Aluminium Metal Matrix Composite etc . In this thesis analysis is performed using C45 and Sialons materials. These materials are considered due to their Specific Properties. In this thesis C45 and Sialons materials are taken. A single plate clutch is designed and modeled using SpaceClaim in Ansys software. Static analysis is done on the clutch to determine stresses and deformations using materials Grey Cast Iron, Sintered Iron, Kevlar, Aluminium Metal Matrix Composite, C45 and Sialons. Analysis is done in Ansys. Theoretical calculations are also done to determine stresses. Keywords: Clutch, Friction Disc, Static Analysis, Ansys, SpaceClaim.
Tipo de familia e inteligencia emocional en enfermeros de un hospital público de Perú
Authors: Camarena Chamaya Luis Miguel , Camarena Chamaya Melina Maura , Gonzales Saldaña Susan Haydee , Fernández Rengifo Werther Fernando , Cárdenas Maria Hilda
Published: May 2022

Introducción: La familia, la más añeja de las instituciones sociales humanas, marca al individuo en sus diferentes etapas de vida y se constituye en un ambiente propicio para el perfeccionamiento de su identidad. Objetivo: Determinar el tipo de familia e inteligencia emocional (IE) en los enfermeros de un hospital público de Perú en la atención de la pandemia. Método: El estudio es transversal con una muestra censal de 80 enfermeros que trabajaron en hospitalización de COVID-19 de un hospital público durante el mes de mayo de 2020 y que contaban con al menos 3 meses de antigüedad. Previo consentimiento informado, se les aplicó una encuesta con el instrumento escala Trait Meta-Mood Scale (TMMS-24) en su versión adaptada y validada al contexto peruano, su fiabilidad alcanzó un coeficiente de alfa de Cronbach mayor a 0,8. Resultados: El tipo de familia que predomina en los enfermeros es nuclear (56,3 %) y la IE es predominantemente baja (36,3%); se destaca el nivel bajo de la dimensión percepción emocional (43,8 %), mientras que las dimensiones de comprensión y regulación de emociones presentan un predominio de nivel excelente (36,3 %) y adecuada (41,3 %) respectivamente. Conclusiones: La IE debería considerarse al momento de diseñar políticas sanitarias de gestión del talento humano y a la hora de la capacitación en servicios de salud.
ANALYSIS OF STUDENT ERRORS IN SOLVING TRIGONOMETRY PROBLEMS BASED ON THE NEWMAN PROCEDURE
Authors: Fauzi Nur Isna , Sagita Laela , Setiyani  , Wicaksono Bintang
Published: May 2022

This study was motivated by student errors in trigonometry. This study aimed to describe the types of student errors in solving trigonometry problems using the Newman error analysis procedure. This research is descriptive qualitative with the subjects of vocational high school students. Data collection involved written tests, depth interviews, and documentation. The results show that most students made comprehension and transformation errors. The comprehension errors consisted of not writing down what was known and asked; immediately writing down the completion process with the wrong formula and incorrect understanding of the concept of the basic trigonometric formula. The transformation errors were not being able to transform information on the problem into the mathematical model, and incorrect in mentioning the formula.
Maximal entanglement increase with single-photon subtraction
Authors: Zhang Kun , Jing Jietai , Treps Nicolas , Walschaers Mattia
Published: May 2022

Entanglement is an indispensable quantum resource for quantum information technology. In continuous-variable quantum optics, photon subtraction can increase the entanglement between Gaussian states of light, but for mixed states the extent of this entanglement increase is poorly understood. In this work, we use an entanglement measure based the Rényi-2 entropy to prove that single-photon subtraction increases bipartite entanglement by no more than log 2. This value coincides with the maximal amount of bipartite entanglement that can be achieved with one photon. The upper bound is valid for all Gaussian input states, regardless of the number of modes and the purity.
Acute Post Trauma Stress Syndrome (PSS) versus Chronic PSS after Armed Operations in Bosna, Yemen versus Lebanon and Syria
Authors: Drgova J. , Suvada J. , Olah M. , Krcmery V. , Dirgova E. , Bachyncova D. , Hunyadiova S. , Irad B. , Ulman S. , Haj Ali P.
Published: May 2022

Post Trauma Stress Syndrome has two forms, acute and chronic; depending on the interval and duration of stress, since this is a typically reactive psychosocial disorder with vegetative medical symptomatology evoked by acute or chronic stress.                                                       The aim of this three cohort comparative study is to compare the position of PTSS between: victims of bombing in Yemen (air strikes only); combined war operations in Ukraine; and combined operations in Syria, and chronic military unrests in Lebanon
Minimal Occurrence of Suspected Tuberculosis among Immigrants of War from Ukraine Shelters and Orphanage in Comparison to HIV Positive Cambodian Children from Orphanage
Authors: Shahum A. , Utesena M. , Benca J. , Polonova J. , Bakos M. , Jackulikova M. , Bachyncova D. , Hunyadiova S. , Grey E. , Hoin l.
Published: May 2022

Armed conflicts are connected with huge migration and refugees of war transfer at borders often without appropriate checks for vaccination, or immunization calendars. Within the last 10 years due to war, sporadic cases of measles and polio have been exported from Syria to Israel or fromAfghanistan to Pakistan and vice versa (l2). The aim of this study was to compare occurrence of Tuberculosis in 2 shelters, 1 with refugees of war and 1 with orphans, 1 from Ukraine and the second in Cambodia and a shelter of homeless people in Jarna Slovakia (3 countries of different incidence of TB).
How Does the Chinese Government Promote the Development of the Social Credit System?
Authors: Zhong Yong
Published: May 2022

This paper introduces the four stages of the construction of China’s social credit system. In combination with the characteristics of the institutional system, this paper describes the specific practices adopted by the Chinese government to promote the construction of the social credit system from six aspects, namely, governing government integrity, business and social ethics and judicial integrity, building the credit information platform, developing third-party credit service institutions and credit service markets, and constructing the social credit system demonstration cities. It argues that the construction of China’s credit system has the problems of insufficient rule of law, imperfect credit platform construction, and difficult credit repair. These problems will be gradually solved in the new phase of the social credit system’s construction starting from 2021, and China will continue to develop and improve its social credit system in the process of solving problems.
“The people have a positive attitude to medicine...” (Medical Inspectors in the Formation of Medical and Sanitary Affairs in the Provinces of Pre-Revolutionary Russia)
Authors: Gurkina N. K.
Published: May 2022

The problem of the history of public administration in the field of medicine and healthcare has never lost its relevance. The Health project has become one of the priority national projects of the last decade. The epidemic that began in 2020 has exacerbated many long-standing problems of Russian medicine: a shortage of medical personnel and medical institutions, insufficient material security of doctors, etc. As a result of the clumsily carried out “optimization” and contradictory actions during the epidemic, the level of confidence of the people and society in the activities of modern health care organizers has fallen. The topic of the state of health care, sanitary and epidemic safety, the role of the state in solving these pressing issues has firmly entered the public discourse, aroused interest in considering historical experience with all its achievements and losses. A significant place in the state administration of medicine and healthcare has always been occupied by specific people — government officials who have made a noticeable and real contribution to the development of health care.

The management of medical and sanitary affairs in the provinces of the Russian Empire was carried out by medical inspectors (the position was established in 1865), as a rule, highly qualified doctors with extensive and diverse practical experience. The materials of the Russian State Historical Archive (St. Petersburg) and local archives allow us to make a typical portrait of this category of managers. In the funds of the Medical Department and the Main Medical Department of the Ministry of Internal Affairs, cases have been postponed in which the official activities and biographies of medical inspectors are characterized. The article examines the main activities of medical inspectors, assesses their contribution to the formation and development of healthcare and medicine in pre-revolutionary Russia. Along with the study of forms and methods of solving medical and sanitary-epidemic problems of the regions by inspectors, the personal qualities of the best managers, which have become the basis for the success of their activities, are also highlighted.
Interaction between the Arctic and Non-Arctic States in Scientific Research and Practical Development of the Geopolitical Potential of the Arctic
Authors: Kefeli I. F. , Nikolaenko A. V.
Published: May 2022

Aim. Reveal the methodological role of ideas about the geopolitical potential of the state in making managerial decisions in the development of the space of the Russian Arctic. The article presents an overview of fundamental research and articles by foreign authors that addresses the problem of realizing the geopolitical potential of the Arctic.Tasks. Development of the principles of geopolitical forecasting based on mathematical modeling of the geopolitical potential of the state and systematization of developments on the spatial development of the Russian Arctic as part of Greater Eurasia.Methods. Mathematical modeling of geopolitical processes, medium-term forecasting of the spatial development of the Russian Arctic in the face of challenges from foreign states claiming its natural resources and territorial waters.Results. It confirms the need to include scientific developments in the methodological apparatus of geopolitical research to identify qualitative and quantitative definitions of the geopolitical potential of the state, which contributes to ensuring the national security of Russia and improving its spatial development.Conclusions. The transition to the sixth technological mode is not limited to a radical transformation of the country’s production complex, but also implies the need to create a unified infrastructure architecture for the Greater Eurasia (“smart” Eurasia), into which the Russian Arctic organically fits.
What are the Immediate Prospects for the Implementation of Innovative Activity of the Domestic Agro-Industrial Complex
Authors: Razuvaev R. A. , Tsatsulin A. N.
Published: May 2022

The innovative development of the agro-industrial complex (AIC) of the Russian Federation is a priority area of state policy, since the agro-industrial complex is the basis for ensuring the country’s food security. Technological and product innovations in the sector will reduce the risks of doing business and provide the domestic and foreign markets with goods that have high consumer value and meet the needs of consumers. The purpose of this study is to substantiate the need for innovative development of the agro-industrial complex and develop recommendations for increasing the innovative activity of agro-industrial enterprises. The objectives of the study are to determine the industry’s contribution to GDP, to determine the level of innovation activity, to analyze development factors, to analyze factors that slow down innovation activity and to draw up appropriate recommendations. Research methods are economic analysis and synthesis. The article shows that the innovative development of the agroindustrial complex largely depends on state support and the creation of a special institution for the transfer of innovative technologies. The main provisions of the article: it is shown that in modern Russia the high potential of agro-industrial production has not been realized; innovative development of enterprises in the agro-industrial complex depends on the import of technologies; Russia has a scientific base and the potential for creating innovative solutions, but in the absence of technology transfer institutions, it cannot be realized; the creation of a special institute for technology transfer will increase the innovative activity and competitiveness of the Russian agro-industrial complex in the domestic and world markets.
Space-time clusters of severe acute respiratory syndrome and COVID-19 and hierarchical urban network in the state of Mato Grosso, Brazil, 2020-2021
Authors: Alves Mário Ribeiro , Souza-Santos Reinaldo , Almeida Andréa Sobral de
Published: May 2022

Objective: to analyze the space-time distribution of COVID-19 in the state of Mato Grosso, Brazil. Methods: Weekly case records of Severe Acute Respiratory Syndrome were obtained from the Ministry of Health’s Database related to this syndrome, including data from COVID-19. Temporal and spatiotemporal analysis using scanning statistics to identify clusters of severe acute respiratory syndrome cases were performed with the software SaTScan. Results: A total of 27,093 cases was observed, with an incidence of 768.33/100,000 inhabitants. The spatial distribution considering the period of study evidenced the heterogeneity of values in the state. The highest incidence rates were observed in more populous municipalities. Conclusion: We highlight priority areas for interventions, aiming at controlling the transmission of the disease and reducing transmission risks to more remote areas of the state of Mato Grosso.
Plastic Asia
Authors: Abrahms-Kavunenko Saskia , Brox Trine
Published: May 2022

This introduction to the special issue of Plastic Asia emphasises the ambiguous and unsettling materiality of plastics. It describes how in Asian contexts, the relationships between plastics, purity and pollution are complex: simultaneously promising purity, quality and hygiene, yet frequently failing to fulfil these promises. It looks at how plastics, for some, have come to signify broader frustrations with modernity and the complexities of plastics when they are incorporated into ritual life.
Plastic Purity and Sacred Dairy
Authors: Reichhardt Björn , Abrahms-Kavunenko Saskia
Published: May 2022

By investigating the growing use of plastics within Mongolian dairying, this paper explores emerging microbial/social assemblages as they relate to local and imported ideas of purity and hygiene. Although many Mongolian herders prefer to use dairy equipment made from materials such as wood and hide, these items are increasingly being replaced by plastic ones. As new infrastructure connects northern herders to more extensive markets, it presents challenges for herders and for the microbial communities with whom they co-exist, placing herders under increasing pressures to compete with large-scale dairy enterprises that brand, package and distribute standardised dairy products. Looking at the changing material culture of Mongolian dairying and its relationships with microbial communities, this paper examines two emergent notions of purity: the first in which sterility is generated and contained and the second in which living dairy is harnessed and grown.
Spatial genetic homogenization of the only clade of the tick Rhipicephalus microplus in the Neotropics.
Authors: Díaz-Sánchez Sandra , Hernández-Triana Luis , labruna Marcelo , Merino Octavio , Mosqueda Juan , Nava Santiago , Szabó Matias , Tarragona Evelina , Venzal José , Fuente Jose de la , Peña Agustín Estrada
Published: May 2022

This study addresses the variability of the mitochondrial cytochrome
oxidase subunit I (COI) and 16S rDNA (16S), and nuclear internal
transcriber spacer ITS2 (ITS2) genes in a set of purposely collected
samples of the cattle tick, Rhipicephalus microplus (Canestrini, 1888)
introduced in the Nearctic-Neotropical range (Mexico to Argentina), and
in geo-referenced sequences from GenBank. The main aims of the study are
(i) to provide evidence of the phylogeny of the tick in the region, as
consequence of a single or several introductions, (b) to explore a
possible impact of environmental traits, and (c) to check for the effect
of geographical distance on genetic variability. We included published
sequences of Rhipicephalus annulatus (Nearctic, Afrotropical and
Mediterranean), R. microplus (Afrotropical, Asia), to fully characterize
the Neotropical populations (total: 74 16S, 44 COI, and 49 ITS-2
sequences included in the analysis). Only clade A of R. microplus spread
in the Nearctic-Neotropics. The K statistic, a measure of phylogenetic
signal, supports low divergence rates of every tested gene in
populations of R. microplus in the target region even under diverging
environmental conditions. This test demonstrates that spatial distance
and genetic variability are negatively correlated. The low variability
of these genes may be due to (i) the recent introduction of the tick in
the Neotropics, (ii) a high degree of panmixia because exchange of
populations, and (iii) low environmental pressures, promoting a lack of
genetic drift. These results have implications for the ecology and
control of cattle tick infestations.
Heart rate variability and its role in predicting atrial fibrillation in patients undergoing coronary artery bypass graft
Authors: Thanh Ngo Van , Nguyen Hien , Son Pham Nguyen , Son Pham Truong
Published: May 2022

Background: An association has been demonstrated between heart
rate variability (HRV) and cardiac events in some diseases. However, the
association with new-onset atrial fibrillation (AF) after coronary
artery bypass graft (CABG) is still controversial. This study aimed to
investigate the association between HRV and new-onset AF in patients
undergoing CABG during a 6-month follow-up. Methods: This
cross-sectional study involved 119 consecutive patients undergoing
off-pump CABG. All patients were assessed with 24-hour Holter recordings
2 days before CABG and 1 week, 3 months, and 6 months postoperatively.
HRV was analyzed, and AF was detected from its recordings. Main
results: In patients undergoing CABG, NYHA III increased the AF rate at
7 days, and advanced age and diabetes were associated with AF at 6
months postoperatively. A reduction in time-domain measurements before
surgery was significantly associated with a higher risk of developing AF
at 7 days postoperatively, no association between preoperative HRV and
AF was found at 6 months. Reduced preoperative HRV (SDNN < 50
ms) was the independent predictor of AF at 3 months (AUC = 0.65) and 6
months (AUC = 0.62) following surgery. Conclusions: A reduction
in time domain before CABG was associated with a higher risk of
new-onset AF at 7 days postoperatively but not at 6 months. SDNN
<50 ms was an independent predictor of higher incidence of AF
at 3 and 6 months post surgery.
Performance of the new nutritional evaluation tool for hospitalized pediatric cancer patients (ANPEDCancer)
Authors: Saraiva Danúbia , Martucci Renata , Monteiro Gina
Published: May 2022

Background: There is a lack of specific nutritional assessment tools for
the pediatric population with hospitalized cancer. The aim was to
evaluate the performance of ANPEDCancer in a pediatric population with
cancer, verifying its ability to detect nutritional inadequacy and
predict the length of hospital stay. Methods: We evaluated 111 pediatric
patients hospitalized in a cancer reference institute in 2019. Patients
were classified as malnourished and well-nourished, according to the
ANPEDCancer, and measures of weight, height, anthropometric indicators,
body composition, laboratory parameters, length of hospital stay, and
death were compared between groups. The ANPEDCancer classification was
compared with the complete nutritional assessment, calculating
sensitivity, specificity, and predictive values, and with prolonged
hospital stay. Results: The prevalence of malnutrition was 12.6%,
nutritional risk was 48.6%, risk of overweight/obesity was 6.3%, and
well-nourished status was 32.4%. According to ANPEDCancer, malnourished
patients showed a higher frequency of inadequacy for all anthropometric
indices, percentage of weight loss, albumin, C-reactive protein (CRP),
and longer hospital stay when compared to well-nourished patients. There
was an association between the tool’s diagnosis and measures of body
composition, CRP, and length of hospital stay. ANPEDCancer validation
with the complete nutritional assessment showed a sensitivity of 81.6%,
specificity of 55%, positive predictive value of 53.4%, and negative
predictive value of 82.5%. The length of hospital stay was almost twice
as long among malnourished patients. Conclusions: ANPEDCancer is
feasible to assess nutritional status and identify the presence of
nutritional risk, allowing targeted assistance in the hospitalized
pediatric cancer patients pediatric.
Outcomes of Liver transplantation in children with Langerhans Cell Histiocytosis: Experience from a quaternary care centre and an algorithmic approach
Authors: Menon Jagadeesh , Shanmugum Naresh , Valamparampil Joseph , Vij Mukul , Kumar Vimal , MUNIRATHNAM DEENADAYALAN , Hakeem Abdul , Rammohan Ashwin , Rela Mohamed
Published: May 2022

Objective : Spectrum of hepatic presentation in Langerhans cell
histiocytosis (LCH) varies from asymptomatic hepatomegaly to secondary
sclerosing cholangitis leading to cirrhosis with or without
decompensation. Conventional chemotherapy may be counterproductive in a
patient with LCH and hepatic decompensation. We analysed the outcomes of
our patients with hepatic presentation of LCH, including their post
liver transplant (LT) follow up. Methods: A retrospective analysis was
performed on patients with hepatic presentation of LCH referred to our
unit. Their clinical profile, chemotherapy protocol, details of LT and
survival were analysed. A management algorithm based on the outcomes was
proposed. Results: Five of 8 patients were male. Median age of diagnosis
was 25(9-48) months. 8(100%) patients had portal hypertension with
4(50%) having decompensated cirrhosis. 6 (75%) patients underwent LT
of which 2 had acute decompensation and 4 had sclerosing cholangitis
with portal hypertension. Of the two remaining patients, 1 did not
tolerate chemotherapy and succumbed, whereas 1 patient after first cycle
of chemotherapy was lost to follow up. As their liver disease was
worsening during chemotherapy (after 8 & 20 weeks of chemotherapy), two
patients underwent urgent LT followed by continuation of chemotherapy.
After median follow-up of 30.5 (10.5-50) months, all patients were alive
with stable graft function and no disease recurrence. Conclusion: As
shown in our series, an algorithmic approach to patient and treatment
selection for LCH patients with liver involvement combined with newer
chemotherapeutic agents and an optimized immunosuppression can result in
excellent outcomes for a hitherto unfamiliar disease.
Clinical and genetic analysis of two patients with primary ciliary dyskinesia caused by a novel mutation of DNAAF2
Authors: Dong Lili , Zhang Lei , Li Xiao , Mei Shiyue , Shen Yuelin , Fu Libing , Zhao Shunying , tang xiaolei , Tang Yu
Published: May 2022

Objective: To investigate the clinical manifestations,
diagnosis and treatment processes of two siblings with PCD caused by the
same compound heterozygous mutations in DNAAF2. Methods: With
clinical diagnosis of PCD, the two siblings were recruited in the study.
We collected their clinical histories, laboratory tests, bronchoscopy,
otoscope images, and radiographic data. Whole blood of the siblings and
their parents were separately harvested for whole-exome sequencing and
Sanger sequencing. Results: The 7-year-old girl presented with
recurrent respiratory tract infection, sinusitis and otitis media.
Auxiliary examinations showed pneumonia, atelectasis, bronchiectasis,
low nitric oxide concentration (nNO), and conducting hearing loss. The
younger brother, 10-month boy, exhibited pneumonia, sinusitis, otitis
media, intestine malrotation and with lower nNO, atelectasis in chest
CT, obstructive ventilator dysfunction by pulmonary function and
conductive hearing loss. Two compound heterozygous mutations in DNAAF2
were detected in both of the siblings, nonsense mutation c.156C＞A and
frameshift mutation c.177_178insA, and the c.177_178insA (p.E60Rfs*3)
mutation is a novel mutation. Conclusion: The study enriches
our knowledge of clinical manifestations and genetic information of PCD
caused by DNAAF2.
Blood cytometry, neutrophil-lymphocyte index and platelet-lymphocyte index in children with high-risk pathologies and COVID-19
Authors: Saucedo Gerardo Palacios , Rivera Celia Herrera , González Adriana Sandoval
Published: May 2022

ABSTRACT Background: The emergence of new SARS-CoV-2 variants is
increasing pediatric COVID-19 cases. The blood cytometry (BC) values,
neutrophil-lymphocyte index (NLI), and platelet-lymphocyte index (PLI)
reflect inflammatory response intensity. The aim was to evaluate if BC,
NLI, and PLI are predictors of the COVID-19 severity in children with
high-risk pathologies. Methods: A retrospective nested case-control
study of 60 pediatric patients with COVID-19 was carried out to evaluate
the relationship of BC, NLI, and PLI with clinical status at the COVID
area discharge. Patients with a severe or critical condition at
discharge and those who died during hospitalization were classified as
cases. Asymptomatic patients or those with a mild to moderate disease at
discharge were considered controls. We used absolute frequencies,
percentages, medians, ranges, X2 test, Fisher’s exact test, and Odds
Ratio with 95% CI for statistical analysis. Results: We included 32
male and 28 female patients, median age of 6.5 years (range 0-14). All
had high-risk diseases, such as Leukemia (64.4%), Down syndrome and
Leukemia (8.8%), or a solid neoplasm (13.3%). Seventeen (28.3%) were
cases and 43 (71.7%) controls. Fourteen (23.3%) died. No BC value was
associated with illness severity, except for thrombocytosis (OR 6.30,
95% CI 1.03-38.48, p=0.048). Erythropenia was identified as a
protective factor for illness severity (OR 0.18, 95% CI 0.03-0.86,
p=0.034). Conclusion: A decrease in different BC values was the most
frequent abnormality. Thrombocytosis was associated with COVID-19
severity. These results may apply to children with high-risk pathologies
such as those in this series.
GIPR Agonism Inhibits PYY-Induced Nausea-Like Behavior
Authors: Samms Ricardo J , Cosgrove Richard , Snider Brandy M , Furber Ellen C , Droz Brian A , Briere Daniel A , Dunbar James , Dogra Mridula , Alsina-Fernandez Jorge , Borner Tito , Jonghe Bart C. De , Hayes Matthew R. , Coskun Tamer , Sloop Kyle W , Emmerson Paul J , Ai Minrong
Published: May 2022

The induction of nausea and emesis is a major barrier to maximizing the weight loss profile of obesity medications, and therefore, identifying mechanisms that improve tolerability could result in added therapeutic benefit. The development of Peptide YY (PYY)-based approaches to treat obesity are no exception, as PYY receptor agonism is often accompanied by nausea and vomiting. Here, we sought to determine whether glucose-dependent insulinotropic polypeptide (GIP) receptor agonism reduces PYY-induced nausea-like behavior in mice. We found that central and peripheral administration of a GIPR agonist (GIPRA) reduced conditioned taste avoidance (CTA) without affecting hypophagia mediated by a PYY analog. The receptors for GIP and PYY (Gipr and Npy2r) were found to be expressed by the same neurons in the area postrema (AP), a brainstem nucleus involved in detecting aversive stimuli. Peripheral administration of a GIPRA induced neuronal activation (cFos) in the AP. Further, whole-brain cFos analyses indicated that PYY-induced CTA was associated with augmented neuronal activity in the parabrachial nucleus (PBN), a brainstem nucleus that relays aversive/emetic signals to brain regions that control feeding behavior. Importantly, GIPR agonism reduced PYY-mediated neuronal activity in the PBN, providing a potential mechanistic explanation for how GIPRA treatment reduces PYY-induced nausea-like behavior. Together, our study provides a novel mechanism by which GIP-based therapeutics may benefit the tolerability of weight loss agents. 
A Case of Osteoarthritis Treated by Homoeopathic Constitutional Medicine: A Case Study
Authors:   Associate Professor, Department of Repertory, R.B.T.S Govt. Homoeopathic Medical College & Hospital, Muzaffarpur, Kumar Ram
Published: May 2022

Abstract Osteoarthritis is now a burden disease in the whole world, it effects person daily activity & causing impairments. It is the major public health challenge to the population. Homoeopathy although widely used in Osteoarthritis, is assumed to have nothing significant but placebo effects and Its specific clinical effects are frequently ascribed as implausible. In this article, I briefly discuss on osteoarthritis and a case, which was treated by Homoeopathic medicine.
Risk Stratification Tool to Develop Framework for Infection Control in Spectrum of Dental Procedures during COVID-19 Pandemic
Authors: Abbas Beenish , Abbas Sana , Saleem Iqra , Asghar Summiya , Gulfam Faiza , Umair Muhammad
Published: May 2022

Objective: To develop a framework for infection control in the spectrum of dental procedures during the COVID-19 pandemic.

Methodology: The study was conducted from Oct to Dec 2021 after approval for ethical review board of Foundation university college of dentistry Ref no (    ). Patients undergoing various dental procedures were enrolled after written and verbal informed consent. Risk Stratification of each procedure was done applying novel risk assessment scoring system, according to the level of risk contact with saliva was given score 1, contact with blood scored as 2, production of aerosol (low level) through triple syringe was given score 3, high aerosol production by ultrasonic piezoelectric instruments was scored as 4. If the complete duration of the dental procedure was >60 min score assigned was 0.75, for procedures with 30 to 60 mins duration score specified was 0.50, if the duration of the procedure was less than 30 min score for that procedure was 0.25. For each patient total score of all these parameters was accumulated to grade risk of SARS -CoV-2 transmission as low (score <4), medium (score 4 to 6), or high (score >6) depending upon the accumulative score of each procedure.

Results: Nine hundred and fifteen patients with a gender distribution of 163 (17.9%) males and 748 (82.1%) females with an age range < 18 – 45 years undergoing the dental procedure were enrolled. Out of 915, 436 (47.6%) procedures were found to be low risk, 38 (4.1%) moderate risk, and 437 (47.7%) high risk. Out of 174 maxillofacial procedures, only 18 (10.3%) were of high risk, similarly out of 113 orthodontics procedures, only 1 (0.9%) was of high risk and for 147 prosthodontic procedures, there were 55 (37.4%) high-risk procedures. On the other hand, for operative dentistry procedures (n=181), majority of 128 (70.7%) posed a high risk, among pediatrics procedures (n=92) there were 62 (67.4%) high-risk procedures and for periodontics (n=204) about 173 (84.8%) were of high-risk nature. Therefore, the majority of the high-risk procedures belonged to operative, pediatrics, and periodontics specialty as compared to other specialties (p<0.001).

Conclusion: The majority of the high-risk dental procedures belonged to operative, pediatrics, and periodontics specialty as compared to other specialties.
Vocational Skill Development and the Reduction of Insecurity in Niger-Delta Region of Nigeria
Authors: Asuquo Effiong E. , Onyema Lizzy N. , Godwin Rosemary Y.
Published: May 2022

This study sought to relate vocational skill development to reduction of insecurity in Nigeria. To achieve this, two research questions were raised and two null hypotheses were formulated to guide the study. A correlational survey design was adopted for the study. A researcher-structured questionnaire titled’’ Vocational Skill Development and Reduction of Insecurity Questionnaire’ (VOSDRINQ) was used for the study. The study made use of 102 vocational education graduates conducting their postgraduate studies in south-south Nigeria. A purposive sampling technique involving 102 vocational education graduates were used for the study. The Pearson Product Moment Correlation (PPMC) was used to analyze the research questions and test the null hypotheses. It was discovered that graduates of Vocational Education who acquire skills agree that skill development relate significantly with reduction of insecurity in Niger-Delta. It was recommended among others that vocational training and skill development should be free for the youth at grass root level.
Practical and Technological Skills: An Inevitable Social Engineering Tool for Sustainable Development
Authors: Laleye Ademiotan M.
Published: May 2022

Education is a social engineering tool that can impact the society as well as the individuals in the society hence, conscious efforts are regularly put in place by curriculum planners and educationists all over the world to design, redesign and review the contents of the educational curricular so as to measure up with immediate and anticipated challenges of human society. In conformity with this lofty desire, the curricular designed particularly for higher levels of education in Nigeria aims at fast-tracking development. Unfortunately, the realization of this goal leaved much to be desired because it is largely premised on the acquisition of theoretical skills. This has hindered personal and society development. This article, therefore, explored how an adequate educational framework can be provided within which the education curricular would facilitate both personal and society development and its sustainability. In doing this, the paper argued for the substantial inclusion of practical and technological skills as complement to the existing theoretical skills that characterized the curricular. It noted that an education curricular that concomitantly prioritizes both theoretical and practical knowledge is key to activating sustainable development in the twenty-first century human society. More so when such practical and technological skills encourage not only hands-on tasks but also facilitate self- reliance, moral excellence, competence, hard works which are indispensable ingredients for sustainable development. The article, therefore, promises to expand the existing paradigm of education for development which is predominantly embarked upon from a single and narrow perspective premised largely on the acquisition of theoretical skills, to include a more embracing and multi-dimensional practical and technological skills acquisition. When practical and technological skills complement the prevalent theoretical skills acquisition drive of the education curricular, this would offer an adequate framework that would facilitate and sustain development. The work employed argumentative and theoretical methods on the educational policies in Nigeria.