bluuebunny/crossref_metadata_2025 huggingface dataset:
Sleep-disordered breathing in patients with COPD and mild hypoxemia: prevalence and predictive variables
Authors: Silva Júnior José Laerte Rodrigues , Conde Marcus Barreto , Corrêa Krislainy de Sousa , Rabahi Helena , Rocha Arthur Alves , Rabahi Marcelo Fouad
Published: July 2017

ABSTRACT Objective: To infer the prevalence and variables predictive of isolated nocturnal hypoxemia and obstructive sleep apnea (OSA) in patients with COPD and mild hypoxemia. Methods: This was a cross-sectional study involving clinically stable COPD outpatients with mild hypoxemia (oxygen saturation = 90-94%) at a clinical center specializing in respiratory diseases, located in the city of Goiânia, Brazil. The patients underwent clinical evaluation, spirometry, polysomnography, echocardiography, arterial blood gas analysis, six-minute walk test assessment, and chest X-ray. Results: The sample included 64 patients with COPD and mild hypoxemia; 39 (61%) were diagnosed with sleep-disordered breathing (OSA, in 14; and isolated nocturnal hypoxemia, in 25). Correlation analysis showed that PaO2 correlated moderately with mean sleep oxygen saturation (r = 0.45; p = 0.0002), mean rapid eye movement (REM) sleep oxygen saturation (r = 0.43; p = 0.001), and mean non-REM sleep oxygen saturation (r = 0.42; p = 0.001). A cut-off point of PaO2 ≤ 70 mmHg in the arterial blood gas analysis was significantly associated with sleep-disordered breathing (OR = 4.59; 95% CI: 1.54-13.67; p = 0.01). The model showed that, for identifying sleep-disordered breathing, the cut-off point had a specificity of 73.9% (95% CI: 51.6-89.8%), a sensitivity of 63.4% (95% CI: 46.9-77.9%), a positive predictive value of 81.3% (95% CI: 67.7-90.0%), and a negative predictive value of 53.1% (95% CI: 41.4-64.4%), with an area under the ROC curve of 0.69 (95% CI: 0.57-0.80), correctly classifying the observations in 67.2% of the cases. Conclusions: In our sample of patients with COPD and mild hypoxemia, the prevalence of sleep-disordered breathing was high (61%), suggesting that such patients would benefit from sleep studies.
Effects of emissions from sugar cane burning on the trachea and lungs of Wistar rats
Authors: Matos Verena Sampaio Barbosa , Gomes Felipe da Silva , Oliveira Tarcio Macena , Schulz Renata da Silva , Ribeiro Lídia Cristina Villela , Gonzales Astria Dias Ferrão , Lima Januário Mourão , Guerreiro Marcos Lázaro da Silva
Published: July 2017

ABSTRACT Objective: To evaluate the effects of exposure to emissions from sugar cane burning on inflammatory mechanisms in tissues of the trachea and lung parenchyma in Wistar rats after different periods of exposure. Methods: This was an experimental open randomized study. The animals were divided into four groups: a control group (CG) underwent standard laboratory conditions, and three experimental groups were exposed to emissions from sugar cane burning over different periods of time, in days-1 (EG1), 7 (EG7), and 21 (EG21). After euthanasia with 200 mg/kg of ketamine/xylazine, fragments of trachea and lung were collected and fixed in 10% formalin. Histological analyses were performed with H&E and picrosirius red staining. Results: No inflammatory infiltrates were found in the tissues of CG rats. The histological examination of tissues of the trachea and lung parenchyma revealed that the inflammatory process was significantly more intense in EG7 than in the CG (p < 0.05 and p < 0.01, respectively). In comparison with the CG and EG1, angiogenesis in the lung parenchyma and collagen deposition in tracheal tissues were significantly greater only in EG21 (p < 0.001 and p < 0.01, respectively). Conclusions: In this sample, emissions from sugar cane burning induced acute focal and diffuse inflammation in the lamina propria of tracheal tissues, with no loss of ciliated epithelial tissue. In the lung parenchyma of the animals in the experimental groups, there was interstitial and alveolar edema, together with polymorphonuclear cell infiltrates.
The impact of asthma in Brazil: a longitudinal analysis of data from a Brazilian national database system
Authors: Cardoso Thiago de Araujo , Roncada Cristian , Silva Emerson Rodrigues da , Pinto Leonardo Araujo , Jones Marcus Herbert , Stein Renato Tetelbon , Pitrez Paulo Márcio
Published: July 2017

ABSTRACT Objective: To present official longitudinal data on the impact of asthma in Brazil between 2008 and 2013. Methods: This was a descriptive study of data collected between 2008 and 2013 from an official Brazilian national database, including data on asthma-related number of hospitalizations, mortality, and hospitalization costs. A geographical subanalysis was also performed. Results: In 2013, 2,047 people died from asthma in Brazil (5 deaths/day), with more than 120,000 asthma-related hospitalizations. During the whole study period, the absolute number of asthma-related deaths and of hospitalizations decreased by 10% and 36%, respectively. However, the in-hospital mortality rate increased by approximately 25% in that period. The geographic subanalysis showed that the northern/northeastern and southeastern regions had the highest asthma-related hospitalization and in-hospital mortality rates, respectively. An analysis of the states representative of the regions of Brazil revealed discrepancies between the numbers of asthma-related hospitalizations and asthma-related in-hospital mortality rates. During the study period, the cost of asthma-related hospitalizations to the public health care system was US$ 170 million. Conclusions: Although the numbers of asthma-related deaths and hospital admissions in Brazil have been decreasing since 2009, the absolute numbers are still high, resulting in elevated direct and indirect costs for the society. This shows the relevance of the burden of asthma in middle-income countries.
Economic evaluation and efficacy of strategic-selective treatment of gastrointestinal parasites in dairy calves
Authors: Blanco Yuly Andrea Caicedo , Barbieri Jonata de Melo , Lima Renato Ribeiro de , Lopes Marcos Aurélio , Reis Eduardo Mitke Brandão , Rocha Christiane Maria Barcellos Magalhães da , Coutinho Adriana de Souza , Guimarães Antônio Marcos
Published: July 2017

Abstract In the Experimental Farm of the Universidade Federal de Lavras (EF-UFLA), state of Minas Gerais, Brazil, on their day of birth, female Holstein calves were randomly selected and placed into two groups containing fifteen animals each: Strategic-Selective Treatment (S-ST) or Conventional Treatment (CT). In the S-ST, calves were treated after coproparasitological examinations according to criteria established previously by the researchers. Calves in the CT were treated according to the opinion of the veterinarian of EF-UFLA. For statistical analysis, the frequency (%) of fecal samples with count of eggs per gram of feces (EPG) ≥300, count of oocysts per gram of feces (OoPG) ≥500 and fecal samples with count of cysts of Giardia spp. ≥1 were conducted. The overall average frequency of fecal samples with EPG ≥300, OoPG ≥500 and Giardia spp. cysts ≥1, respectively, was similar (p >0.05) between S-ST (20.3%; 17.3%; and 31.5%) and CT (26.4%; 23.9%; and 37.3%). The effective operational cost, per animal, in 12 months, was of R$ 784.58 (US$ 241.41) and R$ 83.90 (US$ 25.81) in S-ST and CT, respectively. The S-ST requires adjustments to be used as a technically efficient and economically viable alternative for the control of gastrointestinal parasitosis in female Holstein calves.
Bat trypanosomes from Tapajós-Arapiuns Extractive Reserve in Brazilian Amazon
Authors: Szpeiter Bruno Bernal , Ferreira Juliana Isabel Giuli da Silva , Assis Francisco Flávio Vieira de , Stelmachtchuk Felipe Nascimento , Peixoto Junior Kleber da Cunha , Ajzenberg Daniel , Minervino Antonio Humberto Hammad , Gennari Solange Maria , Marcili Arlei
Published: July 2017

Abstract Trypanosoma comprises flagellates able to infect several mammalian species and is transmitted by several groups of invertebrates. The order Chiroptera can be infected by the subgenera Herpetosoma, Schizotrypanum, Megatrypanum and Trypanozoon. In this study, we described the diversity of bat trypanosomes and inferred phylogenetic relationships among the trypanosomes from bats caught in Tapajós-Arapiuns Extractive Reserve (Resex) in Pará state. Trypanosomes from bats were isolated by means of hemoculture, and the molecular phylogeny was based on the trypanosome barcode (SSUrDNA V7V8 variable region). A total of 111 bats were caught in the area, belonging to three families (Emballonuridae, Molossidae and Phyllostomidae) and 12 species. The bat trypanosome prevalence, as evaluated through hemoculture, was 9% all positive cultures were cryopreserve (100% of isolation success). Phylogenetic trees grouped nine isolates in T. cruzi marinkellei branch and only one in T. dionisii branch. Studies on bat trypanosome diversity are important for identifying pathogenic species and for generating support for control measures, especially in such areas where humans inhabit the forest with close contact with bat species. In addition, this is the first study in Resex Tapajós-Arapiuns extractive reserve and further studies should be conducted to elucidate the role of these parasites as environmental degradation biomarkers.
Fatal toxoplasmosis in an immunosuppressed domestic cat from Brazil caused by Toxoplasma gondii clonal type I
Authors: Pena Hilda Fátima de Jesus , Evangelista Camila Mariellen , Casagrande Renata Assis , Biezus Giovana , Wisser Claudia Salete , Ferian Paulo Eduardo , Moura Anderson Barbosa de , Rolim Veronica Machado , Driemeier David , Oliveira Solange , Alves Bruna Farias , Gennari Solange Maria , Traverso Sandra Davi
Published: July 2017

Abstract The objective of the study was to report on a fatal case of feline toxoplasmosis with coinfection with the feline leukemia virus (FeLV). A domestic cat (Felis silvestris catus) presented intense dyspnea and died three days later. In the necropsy, the lungs were firm, without collapse and with many white areas; moderate lymphadenomegaly and splenomegaly were also observed. The histopathological examination showed severe necrotic interstitial bronchopneumonia and mild necrotic hepatitis, associated with intralesional cysts and tachyzoites of Toxoplasma gondii that were positive by anti-T. gondii immunohistochemical (IHC) evaluation. The bone marrow showed chronic myeloid leukemia and the neoplastic cells were positive by anti-FeLV IHC evaluation. DNA extracted from lungs was positive for T. gondii by PCR targeting REP-529. T. gondii was characterized by PCR-RFLP and by the microsatellites technique. ToxoDB-PCR-RFLP #10, i.e. the archetypal type I, was identified. Microsatellite analysis showed that the strain was a variant of type I with two atypical alleles. This was the first time that a T. gondii clonal type I genotype was correlated with a case of acute toxoplasmosis in a host in Brazil.
Briefing: Towards a sustainable energy: the potential of biomass for electricity generation in Oman
Authors: Umar Tariq
Published: July 2017

Oman, like other Arabian Gulf countries, depends on oil and gas to produce electricity. However, these resources are not guaranteed to last forever and constitute one of the energy security issues in the country. This paper explores the potential of using biomass energy resources for electricity generation in Oman. Energy from biomass resources is counted as a type of renewable energy, which means that its availability is not affected by the lack of sources and the increasing price of fossil oil. The review of biomass energy shows that waste from different sources such as wood and woody plants and their wastes, agricultural crops and residues, municipal solid organic wastes, animal wastes, sewage, waste from organic industrial processing and food processing, and aquatic plants and algae can be used for electricity generation. Biomass from animal manure and waste water are reported as having potential for electricity generation. The results show that a total of 2651·81 GWh/year electricity can be produced from animal manure and waste water, which corresponds to 10% of the total electricity consumption in Oman. Although there is potential to use biomass for sustainable electricity generation, several environmental, social and technological factors associated with biomass energy need to be considered before adopting such resources.
Histopathology of Veins Obtained at Hemodialysis Arteriovenous Fistula Creation Surgery
Authors: Alpers Charles E. , Imrey Peter B. , Hudkins Kelly L. , Wietecha Tomasz A. , Radeva Milena , Allon Michael , Cheung Alfred K. , Dember Laura M. , Roy-Chaudhury Prabir , Shiu Yan-Ting , Terry Christi M. , Farber Alik , Beck Gerald J. , Feldman Harold I. , Kusek John W. , Himmelfarb Jonathan ,   the Hemodialysis Fistula Maturation Study Group
Published: July 2017

Stenosis from venous neointimal hyperplasia is common in native arteriovenous fistulas (AVFs). However, the preexisting histologic characteristics of veins at fistula creation, and associations thereof with baseline patient factors, have not been well characterized. In this study, we conducted histologic analysis of a segment of the vein used for anastomosis creation, obtained during AVF creation from 554 of the 602 participants in the multicenter Hemodialysis Fistula Maturation Cohort Study. We quantified intimal and medial areas and lengths of the internal and external elastic lamina by morphometry and assessed venous wall cells by immunohistochemistry, extracellular matrix with Movat stain, and calcium deposition by alizarin red stain. We also studied a representative subset of veins for markers of monocyte/macrophage content, cell proliferation, apoptosis, and neoangiogenesis. Neointima occupied >20% of the lumen in 57% of fully circumferential vein samples, and neointimal hyperplasia associated positively with age and inversely with black race. The neointima was usually irregularly thickened, sometimes concentric, and contained α–smooth muscle actin–expressing cells of smooth muscle or myofibroblast origin. Proteoglycans admixed with lesser amounts of collagen constituted the predominant matrix in the neointima. In 82% of vein samples, the media of vessel walls contained large aggregates of collagen. A minority of veins expressed markers of inflammation, cell proliferation, cell death, calcification, or neoangiogenesis. In conclusion, we observed preexisting abnormalities, including neointimal hyperplasia and prominent accumulation of extracellular matrix, in veins used for AVF creation from a substantial proportion of this cohort.
Cold Spicy Sichuan Noodles v1
Authors: Ye Hao
Published: July 2017

Inspired by Ba Ren (RIP), sour, a little sweet, numbing spiciness. I added in some lightly-pickled cucumbers for extra crunch.
Peculiarities of placental microRNA expression in pregnancies complicated by gestational diabetes mellitus and preeclampsia
Authors: Pakin Vladimir S. , Vashukova Elena S. , Kapustin Roman V. , Arzhanova Olga N. , Glotov Andrey S. , Baranov Vladislav S.
Published: July 2017

The aim of study was to determine feasible changes of placental miRNAs expression profiles revealed by next generation sequencing (NGS) in pregnancies with GDM complicated or not with PE. Out of 27 miRNAs, studied expression was significantly different (FDR < 0.05) only for his-miR-45a. Comparative analysis of revealed reliable differences in expression of hsa-miR-4532 (p < 0.0001, FDR = 0.0008), hsa-miR-34c-5p (p < 0.0001, FDR = 0.0083), and hsa-miR-193b-5p (p < 0.0001, FDR = 0.0139) in pregnancy complicated by PE, without of GDM. The present results suggest that GDM and PE are associated with specific alterations in the placental miRNA expression profiles. Further studies are needed to verify the role of these microRNA in molecular mechanisms underlying GDM and PE pathogenesis.
Рlacental chorioangiomas: diagnosis and management
Authors: Shelaeva Elizaveta V. , Prokhorova Victoria S. , Nagorneva Stanislava V.
Published: July 2017

Four cases of pregnancies with nontrophoblastic placental tumor – chorioangioma are presented in this article. Clinical symptoms depend on tumors size, vascularisation and histological types (angiomatoid, cellular and degenerative). Small tumors with poor vascularisation are essentially asymptomatic. Large ones can act as peripheral arteriovenosus shunts resulting in fetal functional disorders (polycythemia, hypervolemia, ventriculomegaly) associated with acute polyhydramnion, premature labor, maternal and neonatal complications. The role of ultrasound and color Doppler examinations, invasive procedures (amniocentesis) in the diagnosis of chorioangioma and management of such pregnancies are discussed.
Role of natural killer cells in reproductive failure
Authors: Agnaeva Alana O. , Bespalova Olesya N. , Sokolov Dmitriy I. , Selkov Sergey A. , Kogan Igor Yu.
Published: July 2017

Reproductive losses are quite frequent in the modern world. They include: infertility, infertility of unknown etiology, multiple losses when IVF, recurrent implantation failure, miscarriage, recurrent miscarriage, both in the natural cycle and after ART management. It is important to note that the classification of some of these categories are not established yet. The etiology of reproductive losses is extremely diverse. Successful development of pregnancy at early terms is determined by genetic and immunological factors. Among the reproductive failures of unclear etiology, immunological causes are 50-80%. Over the past 20 years there are already known many different immunological factors that play role in the processes of fertilization. In this case, the evidence base on the role of each of them in the pathogenesis of reproductive failures is only being formed. Currently, the immunological relationship between mother and fetus is considered as a two-way communication process: the presentation of fetal antigens on the one hand, and on the other – the recognition and response to these antigens of the maternal immune system. Implantation of the embryo is accompanied by an increase in the production of proinflammatory cytokines followed by a sharp change in the cellular composition in the decidualizing endometrium, and the main population is NK cells. That is why this type of cells have a significant role in the normal development of pregnancy. The properties of NK cells in the uterus and peripheral blood are significantly different. To predict the onset and prolongation of pregnancy, peripheral blood NK (activity and quantity) is used. Evaluation of endometrial NK is often performed for the diagnosis of chronic endometritis. Currently, the definition of NK cells in peripheral blood in many clinics is proposed as a useful diagnostic test to address the issue of further appointment of immunoglobulins and evaluating the effectiveness of this therapy in patients with reproductive losses.
Selection of the method for correction of cervical incompetence
Authors: Bespalova Olesya N. , Sargsyan Gabriel S.
Published: July 2017

Cervical incompetence (CI) is one of the challenges of modern obstetrics. The practicing obstetrician-gynecologist faces a complex task of timely diagnosis, selection of correction method, timing of application and removal of cerclage. The problem of CI in pregnancy is known from the XIX century, but in the XI century, the outstanding scientist Abu Ali Ibn Sina (Avicenna) wrote about this pathology. According to the classical definition, CI is the softening, widening and shortening of the cervix prior to the 37th week of gestation in the absence of thretening termination of pregnancy. CI is characterized by inability to carry a pregnancy to full-term due to functional or structural abnormalities of the uterine cervix. To date, no objective diagnostic tests exists to identify patients at high risk of developing CI, not before and not during pregnancy. A high diagnostic accuracy during pregnancy can be reached with transvaginal ultrasound of the cervix. The ultrasound scale proposed by Salomon LJ allows to measure the length of the cervix depending on the gestational age and assists in making the right choice for the correction of short cervix. The selection of the method of correction of CI depends on the clinical situation, history, timing of gestation, the number of fetuses, cervicometry data, gynecological examination, the threat of abortion, and the doctor’s experience. There are two main methods of correction of CI: conservative and surgical. Surgical methods include transvaginal and transabdominal cerclage, while conservative includes adherence to bed rest, tocolytics, hormonal therapy, and the use of obstetric pessaries. Insertion of obstetric pessaries is a promising, safe, simple method of treatment and prevention of CI and for threatening termination of pregnancy in the II and III trimesters. The strategy of widespread use of pessaries in pregnant women from high-risk groups can reduce the frequency of preterm labor and improve perinatal outcomes.
Aromatase inhibitors in “poor” ovarian responders undergoing in vitro fertilization
Authors: Merkulova Alexandra I.
Published: July 2017

Since the IVF treatment expands worldwide, it has become apparent that a proportion of women responds suboptimally to controlled ovarian stimulation with exogenous gonadotrophins. There is still no consensus on the ideal controlled ovarian stimulation protocol for patients with “poor” ovarian response. Many strategies have been studied. However, no compelling advantage for one treatment protocol over another has been identified. The addition of aromatase inhibitors in “poor” responders stimulation protocols is described in this article.
The intrapartum fetal occiput posterior position predictors
Authors: Arnt Olga S. , Bolotskikh Vyacheslav M.
Published: July 2017

Fetal malpresentation, including persistent occipitoposterior position, is a major cause of cesarean section. Maternal outcomes are often worse are more common than with fetal occiput anterior positions. To identify maternal risk factors associated with persistent occiput posterior position at delivery. Calculations were made to predict the implementation of the fetal rotation.
The contribution of polymorphism in VDR gene FОKI in the development of osteopenia in pregnancy
Authors: Bibkova Olga S. , Sudakov Dmitriy S. , Bogdanova Evdokia O. , Shaporova Natalia L. , Zazerskaya Irina E. , Galkina Olga V. , Dymarskaya Yulia R.
Published: July 2017

The study involved 89 postpartum women and 97 nonpregnant women aged 20 to 35 years. The results of a genetic test compared with the BMD. In parturients in the lumbar spine the highest IPC and the value of the Z-scores were in patients with genotype FF, and the lowest with the genotype ff. Patients with the heterozygous genotype were charac terized by intermediate values of the BMD and Z-scores in the lumbar spine. A similar results was observed in the proximal femur and the distal forearm. The results of the correlation analysis showed a moderate negative correlation between the ff genotype and the level of BMD in lumbar spine (r = –0,44; p < 0.05) and proximal femur (r = –0.37; p < 0.05).
Expression of cd35 and cd57 in placenta of women with asthma
Authors: Dymarskaya Yulia R. , Zubzhitskaya Lyudmila B. , Lavrova Olga V. , Shapovalova Elena A. , Sudakov Dmitriy S.
Published: July 2017

Background. Prevalence of asthma (BA) among pregnant women reaches 12%. Obstetric complications (preeclampsia, placental insufficiency, IUGR, etc.) mainly occur in the absence of control of asthma. Aspects of the placenta status in women with chronic allergic respiratory disease are not well understood.

Purpuses and tasks — studying the expression of markers of immature dendritic cells (CD35) and natural killer (CD57) cells in the placenta of patients with asthma, depending on the of severity, control and the type of therapy.

Materials and methods. The study involved 200 pregnant women, including 170 with asthma (44 patients with mild intermittent, 52 with mild persistent, 61 with moderate and 13 with severe asthma), and 30 patients without pulmonary and allergic diseases. We analized complications and pregnancy outcomes, conducted the immunohistochemical study of placental samples of 134 patients for the expression of CD35 (marker of immature dendritic cells) and CD57 (marker of NK cells) on cryostat sections, immunomorphological study of the placenta with determination of the fixation of pathogenic immune complexes (PIC), IL-6, IL- 4, IL-10 in the placenta.

Results. CD35 expression in the placenta of women with asthma is increased, while in patients undergoing preeclampsia CD35 expression is lower, especially in cases of uncontrolled asthma in the 3rd trimester. In all cases with persistent and incompletely controlled asthma, the expression of the natural killer marker (CD57) in the placenta correlates with the presence of PIC, IL-6, IL-4, IL-10 and inflammatory changes in the placenta. Conclusions. The results of the study suggest that a decrease in CD35 expression in cases with the combination of uncontrolled persistent asthma and preeclampsia seems to deplete the mechanisms of the immune response. Increased NK cell marker expression (CD57) in the placenta of women with uncontrolled and persistent asthma indicates on the cytotoxic role of this subpopulation of cells, leading to morphological and immune changes in the placenta that adversely affect the fetus and newborn.
Advisability of using early generation Cephalosporines for prevention and treatment of postpartum infection
Authors: Korobkov Nikolay A.
Published: July 2017

Introduction: the following research investigates an availability of a long-lime treatment of postpartum infection by using of Cephalozolin (the Cephalosporine of generation I).

Matherials and Methods. Lochia samples were obtained from the uterine cavities of 21 puerperal women who did not receive drug after delivery and were cultured for the identification and the determination of the susceptibilities of the clinical isolates to Cephalozolin. The concentrations of Cephalozolin in the supernatants were measured by highperformance liquid chromatography.

Results. We determined the sensivity of the most clinically important bacteria to Cephazoline and its penetration rate to the uterine cavity. We found out the following bacteria which are sensible to Cephazoline – S. agalactiae, E. coli, K. pneumoniae, E. aerogenes. A low rate of Cephazoline ≤ 0,78 mg/ml was inhibited the growth of mentioned above bacteria. Cephazoline is also active as for S. aureus – MIC90 and was equal 3.13 mg/ml. In 3 hours after the injection of 1.0 gr of Cephazoline there was a maximum concentration in a venous blood – 1.63 mg/ml. The concentration of Cephazoline in lochia was rising gradually and it maximum in the uterus cavity in 5 hours was 1.26 mg/ml, and then its slowly went down.

Conclusions. The mention above results let us suggest that Cephazoline is penetrates actively to lochia and its still has a good antibacterial effect. Cephazoline is still a treatment of choice as for prevention and a treatment of postpartum surgical site infections by a sensitive microorganism.
Treatment of diffuse toxic goiter during pregnancy
Authors: Lovkova Julia S. , Potin Vladimir V. , Tkachenko Natalya N. , Shelayeva Elisaveta V.
Published: July 2017

We have studied an influence of diffuse toxic goiter on the flow and outcome pregnancy. 67 pregnant women with diffuse toxic goiter were examined. The group of comparison consisted of 38 pregnant women without thyroid pathology. The levels of free thyroxin, TSH, autoantibodies to TSH-receptors and autoantibodies to thyreoperoxidasis in the blood of pregnant women and umbilical cord blood and ultrasound of the thyroid gland of newborns were analyze. Pregnancy and childbirth of the women with unresolved thyrotoxicosis were more complicated by the threat of termination of pregnancy, preeclampsia, chronic placental insufficiency, preterm rupture of membranes, fetal hypotrophy and hypoxia. A high incidence of subclinical hypothyroidism (more 50%) in newborns is associated with the transplacental pass thyreostatic drugs. Subclinical hyperthyroidism in 17% of newborns should be associated with the transplacental transition from the mother to the fetus of autoantibodies to TSH-receptors.
Asymptomatic placental abruption in the third trimester of pregnancy
Authors: Nagorneva Stanislava V. , Prokhorova Victoria S. , Shelaeva Elizaveta V. , Tral Tatyana G. , Sosnina Aleksandra K. , Tolibova Gulrukhsor H.
Published: July 2017

The article presents 3 clinical cases of asymptomatic placental abruption, diagnosed occasionally during routine ultrasound. There were analyzed risk factors of placental abruption: thrombophlia, diabetes, perinatal losses. All cases demonstrated complete coincidence of ultrasonic and morphological data in placental abruption. The patients had been delivered successfully due to correct diagnostics and severe maternal and fetal complications were not realized.
Bioresorbable Vascular Scaffold: A Pioneering Solution for In-Stent Restenosis of stent fracture on right coronary artery
Authors: Granata Francesco , Moscarella Elisabetta , Caliendo Luigi , Varricchio Attilio
Published: July 2017

Stent fracture (SF) is a rare adverse complication that might occur in peripheral and coronary artery, particularly with sirolimus-eluting stent (SES). The structural characteristics of this device with closed cell design and stainless steel scaffolding prompts to a probable fracture of stent. This   adverse event is strongly associated with in-stent restenosis (ISR), target lesion revascularization (TLR) and stent thrombosis (ST). We report the fluoroscopic and tomographic patterns of fractured stent associate with restenosis and thrombotic sub-occlusion treated by bioresorbable vascular scaffold (BVS). To our knowledge, this is the first published report of SF that was treated by BVS.
Pattern of Congenital Heart Defects in 22q11 Microdeletion Syndrome in India – A Tertiary Care Cardiac Hospital Based Study
Authors: Kiran Viralam S , Shrivastava Yash S , Patil Siddaramappa J , Shah Sejal S
Published: July 2017

Background: To investigate pattern of Congenital Heart Defects in 22q11 microdeletion syndrome.

Methods: A retrospective study from year 2006 to 2015 of children with 22q11 microdeletion and pattern of Congenital Heart Defects.

Results: Ninety-Six children with Fluorescent in-situ Hybridisation positive for 22q11.2 microdeletion and Congenital Heart Defects were identified. Out of these 96, the most common Congenital Heart Defect variants were Tetralogy of Fallot (39.58%), Pulmonary Atresia with Ventricular Septal Defect (29.16%), and isolated Ventricular Septal Defect (10.4%). Conotruncal defects constituted majority (82%) followed by Ventricular Septal Defects. Two rare associations were: one child with mitral valve prolapse & another with left pulmonary vein stenosis.

Conclusion: 22q11.2 microdeletion syndrome is commonly associated with Congenital Heart Defects. Among children with Congenital Heart Defects and 22q11.2 microdeletion, conotruncal malformations were the most common defects followed by Ventricular Septal Defect.
Percutaneous Removal of Late Embolization of the Atrial Septal Occluder Device from Abdominal Aorta at the Level of the Superior Mesenteric Artery
Authors: Iyisoy Atila , Ozturk Cengiz , Karademir Ibrahim , Demirkol Sait , Guler Adem , Sahin Mehmet Ali , Yildirim Ali Osman , Demir Mustafa , Balta Sevket , Celik Turgay
Published: July 2017

<span style="line-height: 115%; font-family: 'Times New Roman','serif'; font-size: 12pt; mso-fareast-font-family: 'Times New Roman'; mso-fareast-theme-font: minor-fareast; mso-ansi-language: TR; mso-fareast-language: TR; mso-bidi-language: AR-SA;">Here, we report a case of late device embolization to the abdominal aorta at the level of the superior mesenteric artery, approximately one month after percutaneous closure of an ASD. 
Effects of Renal Sympathetic Denervation in Diastolic Heart Function in CKD Refractory Hypertensive Patients
Authors: Kiuchi Márcio Galindo , Graciano Miguel Luis , Magalhães de Queiroz Carrei Maria Angela , Kiuchi Tetsuaki , Lugon Jocemir Ronaldo
Published: July 2017

Diastolic heart failure (HF) is an important factor that increases mortality related to the cardiovascular system in patients with chronic kidney disease (CKD) whose extent of kidney function deterioration differs. As a non-invasive method to allow early assessment, the E/e’ ratio estimated by tissue Doppler imaging can predict mortality and cardiovascular events in CKD patients with diastolic dysfunction. The current study evaluated 15 patients with CKD and left ventricular hypertrophy (LVH), who were selected according to a previously published protocol. In the present study, we reported for the first time the improvement in diastolic parameters measured by echocardiography in CKD patients with resistant hypertension and left ventricular hypertrophy 6 months after renal sympathetic denervation (RSD). Our results suggest that RSD in this kind of patients seems to avoid the progression to diastolic HF.
Hyperemic Instantaneous Wave-Free Ratio Provides the Hemodynamic Outcome for Moderate to Severe Coronary Artery Stenoses
Authors: Kanamori Yoshishige , Yoshikawa Fumitsugu , Aikawa Ryuichi
Published: July 2017

Background: The fractional flow reserve (FFR) has been established as a physiological tool for the assessment of coronary ischemia. The instantaneous wave-free ratio (iFR) is an alternative pressure-derived physiologic index from the diastolic wave-free period in stable conditions. The hyperemic iFR (h-iFR) may represent a diagnostic tool; however, its diagnostic performance is unclear. Thus, we aimed to assess the diagnostic performance of the h-iFR compared with the conventional whole-cycle FFR.

Methods: Fifty consecutive lesions, which were diagnosed as 50-75% stenosis by coronary angiography, were analyzed regarding the h-iFR and FFR during the intravenous administration of adenosine using a pressure wire. The h-iFR and FFR were calculated via automated algorithms.

Results: Twenty-two stenoses were positive (FFR ≦0.8), and 28 stenoses were negative (FFR >0.8). The slope of the regression line was 1.28 in the positive group and 1.61 in the negative group. The FFR and h-iFR values ranged from 0.64 to 0.80 (0.75±0.04) and 0.52 to 0.82 (0.66±0.07), respectively, in the positive group and 0.81 to 1.02 (0.90±0.05) and 0.69 to 1.02 (0.87±0.08), respectively, in the negative group. The means of the differences between the FFR and h-iFR were 0.027 and 0.090 in the FFR positive and negative groups, respectively.

Conclusions: The hyperemic iFR, which is calculated using the diastolic phase and exhibited a larger dynamic range than the FFR, especially in FFR-positive stenosis, may be a better physiological tool than the cardiac full-cycle FFR in the evaluation of coronary ischemia.

 
Computational Fluid Dynamics as a Tool in the Development Process of Left Ventricular Assist Devices
Authors: Zuin Marco , Rigatelli Gianluca , Picariello Claudio , Faggian Giuseppe , Roncon Loris
Published: July 2017

Computational fluid dynamic analysis (CFD) have recently been applied in study the of cardiovascular system. Since the development of the first blood pumps in the early 1990’s this mathematical technique has been adopted in determining pressure-flow relationship and efficiencies before building left ventricular (LV) assist devices (LVADs) prototypes. Improvements in the functionality of these devices are desirable and for this aim CFD could be a valid tool both in projection and development.
Non-Invasive Programmed Stimulation in Hypertensive Patients with Heart Failure and ICD after Renal Sympathetic Denervation
Authors: Kiuchi Marcio Galindo , Chen Shaojie
Published: July 2017

A recent study reported in patients with ICDs and refractory ventricular arrhythmias, that renal sympathetic denervation (RSD) was associated with reduced arrhythmic burden with no procedure-related complications. Our results show that after RSD becomes more difficult to induce VT/VF using NIPS protocol in comparison to patients who received only increase the dosage of β-blocker, and also that the number of subjects who developed VT/VF was 40% lower in the group submitted to RSD, in the third month after ICD implantation.
Assessment of short term hearing improvement in patients of cartilage interposition ossiculoplasty for lenticular process of incus necrosis in cases of chronic suppurative otitis media: mucosal disease
Authors: Mhashal Shashikant K. , Shetty Neeraj R. , Rathi Amit S. , Gite Vinod A.
Published: July 2017

Background: Chronic suppurative otitis media is a highly prevalent disease in developing countries. Hearing loss associated with this disease is significantly more in cases associated with ossicular necrosis along with tympanic membrane perforation.

Methods: We would like to present a study of such cases of mucosal chronic suppurative otitis media associated with lenticular process necrosis treated by cartilage interposition ossiculoplasty. The patients were followed up for a minimum period of 6 months and their pre op and post op hearing was documented and analyzed.  

Results: An average air bone gap of 39.07 decibels in pre op was reduced to 18.13 decibels in post-operative period and these improvements persisted over 6 months of follow-up.

Conclusions: We have hereby concluded that the hearing improvement is comparable to other methods of ossiculoplasty with minimum disruption of natural hearing assembly in lenticular process of incus necrosis.

 
A randomized study comparing the efficacy of mometasone furoate and fluticasone furoate on the ocular and nasal symptoms of allergic rhinitis
Authors: Bakshi Satvinder Singh , Gopalakrishnan Surianarayanan , V. Nirmal Coumare
Published: July 2017

Background: Ocular symptoms like itching, redness and congestion are common in patients with allergic rhinitis. These symptoms affect the quality of life and increase the burden on the healthcare cost. Intranasal steroids are effective in reducing the nasal and ocular symptoms of allergic rhinitis. We aim to compare the efficacy of mometasone furoate nasal spray and fluticasone furoate nasal spray in reducing the nasal and ocular symptoms of allergic rhinitis.

Methods: 90 patients with perennial allergic rhinitis and ocular symptoms were randomly divided into 2 groups. Group A (n=46) received 200 µg of mometasone furoate nasal spray once daily and Group B (n=44) received 110 µg of fluticasone furoate nasal spray daily. The patients were assessed by total ocular symptom score [TOSS] and total nasal symptom score [TNSS] at 2, 6 and 12 weeks interval.  

Results: There was a statistically significant reduction in both the groups in respect to the TOSS and TNSS scores. However the improvement in the TOSS score in the fluticasone furoate group was more than the mometasone furoate group by 6 weeks (p=0.0009), which continued till the 12 weeks (p=0.045).

Conclusions: Fluticasone furoate is more effective than mometasone furoate in managing the ocular and nasal symptoms of allergic rhinitis. 
Functional outcome of Schatzker type V and VI tibial plateau fractures managed with open reduction internal fixation using dual plates
Authors: Jagdev Saranjeet Singh , Pathak Subodh Kumar , Salunke Abhijeet , Maheshwari Pritam , Ughareja Prahlad , Shah Shaurya
Published: July 2017

Background: Complex tibial plateau fractures remain a challenge to even the most experienced surgeons. These injuries usually affect the young population in their productive years thereby causing socioeconomic impact. We performed a retrospective study to evaluate the functional outcome of of Schatzker type V and VI managed through open reduction and internal fixation.

Methods: 26 patients with Schatzker type V and type VI tibial plateau fractures treated with open reduction and internal fixation using plates were included in the study. Three patients were lost to follow up, 23 patients were evaluated in the final analysis. The preoperative, intraoperative data was noted from the indoor files.The final evaluation was done using Oxford knee score and VAS score.

Results: There were nine Schatzker type V fractures and 14 patients with Schatzker type VI fractures. The mean duration of follow-up was 68.32 months ranging from 41 months to 126 months. The mean Oxford knee score was 39.78. Patients with Schatzker type VI had mean OKS of 37.7.The mean MPTA and mean PPTA were 88.75 degrees and 7.35 degrees respectively. Average VAS Score was 2.8 ranging from 1 to 3.9. All patients returned to their pre-injury level of activity and employment. There were no patients of deep infection.

Conclusions: We conclude that open reduction and internal fixation of high-energy tibial plateau fractures gives excellent to good functional outcome with minimal soft tissue complications. The complications can be minimized with proper patient selection and soft tissue dissection.
Модель среднесрочного экономического цикла и ее предварительная проверка с помощью индекса опережающих индикаторов и некоторых других показателей
Authors: Петухов Валерий Александрович
Published: July 2017

Показана основная структура авторской модели среднесрочного экономического цикла. Автором приводятся доказательства, что эта модель в целом соответствует современным эмпирическим показателям: различным компонентам индекса опережающих индикаторов и темпам прироста реального ВВП. С данной статьей будет полезно ознакомиться специалистам по современной экономической цикличности и по истории экономической мысли.
Особенности и тенденции развития промышленного туризма: региональные аспекты
Authors: Никулина Юлия Николаевна , Трусов Сергей Владимирович Сергей Владимирович
Published: July 2017

Промышленный туризм в субъектах Российской Федерации имеет значительный потенциал для своего развития, поэтому крайне необходима заинтересованность органов государственной власти и туристских агентств в его продвижении. Статья посвящена исследованию актуальных аспектов развития промышленного туризма в регионах Российской Федерации. Авторы проанализировали систему информационного обеспечения процесса развития промышленного туризма на уровне федеральных округов и регионов РФ на предмет упоминаний в средствах массовой информации об экскурсиях на промышленные предприятия, проводимых на регулярной основе, а также были проанализированы порталы региональных министерств по развитию туризма в части наличия на них конкретных разделов, посвященных промышленному туризму. В статье рассмотрен опыт регионов Приволжского федерального округа в области организации и проведения промышленных экскурсий и сформулированы основные группы целевой аудитории объектов промышленного туризма. Авторами разработаны основные направления стратегии по развитию и продвижению промышленного туризма в современных условиях: концентрация на исторически значимых производственных предприятиях; охват большего количества целевых групп потребителей промышленного туризма; создание специального интернет-портала, посвященного промышленному туризму; координация работы региональных органов власти, торгово-промышленных палат регионов, туристических фирм и промышленных предприятий в области организации и проведения промышленных экскурсий.
Исследование выполнено при финансовой поддержке Отделения гуманитарных и общественных наук РФФИ и Правительства Оренбургской области (проект № 17-12-56023 «Разработка новых подходов к развитию промышленного туризма в регионе (на примере Оренбургской области)»).
PLANNING, DESIGNING AND IMPLEMENTATIONOF NETWORK AT CORPORATE LEVEL
Authors: Rajesh Kale , Akshay Dabade , Rahul Khatri , Yadav Nilesh
Published: July 2017

The computer networking technology has entered almost in all aspects of day to day life. In today’s world life has become fast and human does not like to waste their precious time, many technologies have been introduced in market to fulfill human needs. As we written above network technology are entering in all aspect of day to day life. The people want almost all things faster and reliable so we are tried to apply that in our project. We tried to make our project reliable, fast and most important secured.
“A CASA DE FARINHA É A MINHA MORADA”: TRANSFORMAÇÕES E PERMANÊNCIAS NA PRODUÇÃO DE FARINHA EM UMA COMUNIDADE RURAL NA REGIÃO DO BAIXO TOCANTINS-PA
Authors: Linhares Anny Da Silva , Dos Santos Clarissa Vieira
Published: July 2017

Este artigo objetiva analisar as principais transformações ocorridas no processo produtivoda farinha. Pretende também apontar as permanências no que se refere à compreensãoda casa de farinha enquanto espaço de sociabilização. E assim traçar uma análise a respeito decomo as transformações ocorridas no processo de beneficiamento da mandioca têm influenciadona dinâmica social deste espaço ao longo do tempo, através da memória dos atores locaisque protagonizam, constroem e reconstroem o sabe-fazer-farinha diariamente na comunidadede Baratinha, localizada no município de Mocajuba-PA. A metodologia abrangeu a observaçãoparticipante, entrevistas semiestruturadas, fotos etnográficas das casas de farinha e daspráticas de beneficiamento, envolvendo efetivamente quatro famílias e a participação diretaem suas atividades produtivas. Como resultado, identificou-se que apesar das transformações(instrumentais e práticas) revelarem importante progresso na produção, houve mudançasrelacionadas à organização do trabalho, diminuição dos mutirões, interesse dos jovens e damanifestação cultural do Samba do Cacete. Todavia, a casa de farinha permanece sendo umamorada que abriga a família, parentes e vizinhos na produção e reprodução de uma cultura.
LIMITAÇÕES AO USO AGROPECUÁRIO DAS TERRAS FIRMES NA AMAZÔNIA E TRANSFORMAÇÃO DOS SISTEMAS DE PRODUÇÃO DOS AGRICULTORES FAMILIARES NO TERRITÓRIO DO BAIXO TOCANTINS
Authors: Martins Paulo Fernando da Silva , Pereira Moacir José Moraes , De Matos Francinaldo Ferreira , Da Silva Júnior Bruno Ribeiro , Scalabrin Andreia Cristine
Published: July 2017

Na Amazônia, é possível promover o uso das terras, de forma aceitável, através de uma gestão compatível com a fertilidade do meio natural. Para isso é necessário que, por um lado, se conheça as relações entre as formas de uso e o meio ambiente e, por outro, as características do meio natural e as condições dos utilizadores desse meio. Estudos que relacionam, através de metodologias econômicas e estatísticas, o valor bruto da produção, em diversas expressões temporais e espaciais, com dados sobre crédito de fomento e produção de C & T, considerando o conjunto de estabelecimentos de agricultura familiar, indicam para estes a existência de um fraco ambiente institucional. Apesar desse ambientedesfavorável, o fomento praticado inicialmente pelo FNO e depois pelo PRONAF, ermitiram a transformação de sistemas de produção com a inclusão de culturas permanentes, pecuária de corte e pecuária de leite. A silvicultura e a pecuária de leite são, na Amazônia, as produções que associam maior possibilidade econômica de expansão com capacidade endógena de desenvolvimento. A pecuária de corte, que tem maior expressão no grupo patronal, é a que tem menor capacidade endógena de desenvolvimento.No Território da Cidadania do Baixo Tocantins os sistemas de produção agrícola maisimportantes são os de cultivos temporários e de cultivos permanentes. Os cultivos temporários na terra firme, pela dificuldade de intensificação nos moldes da agricultura industrial, não constituem a melhor opção para os agricultores familiares. Por outro lado, existem, já acumulados, procedimentos de base agroecológica, que constituem inovações, que vêm sendo difundidas por ONGs. São exemplos: a proteção do solo com a “palhada” dos cultivos; a manutenção das capoeiras ou a introdução de sistemas de produção, como os sistemas agroflorestais, a horticultura, a fruticultura e a apicultura, conforme sãopraticados hoje por diversos agricultores incentivados pela Associação Paraense de Apoio às Comunidades Carentes. Estes procedimentos permitem a intensificação do trabalho, sendo mais compatível com a manutenção da biodiversidade e da biomassa, e que tem um menor efeito na degradação do solo, além de maior capacidade de expansão por atenderem a mercados urbanos regionais.