bluuebunny/crossref_metadata_2025 huggingface dataset:
La restauración del poder patriarcal en la familia. Prácticas de crueldad hacia niños, niñas y adolescentes víctimas de violencia y hacia sus madres protectoras
Authors: Vazquez Andrea Karina , Tuana Nageli Andrea
Published: September 2024

La violencia hacia niños, niñas y adolescentes que se ejerce en el ámbito doméstico es producto de un orden político patriarcal donde se establecen las primeras relaciones de poder y dueñidad y se consolida la dominación masculina. Estos crímenes se cometen en el ámbito más sagrado de una persona: el hogar, sin testigos. La palabra de niñas y niños suele ser la única evidencia en casos de violencia sexual paterna. No hay más testigos que la propia víctima. Los violentos y abusadores sexuales lo saben, y cuentan con la complicidad patriarcal de quienes deberían juzgarlos y condenarlos. Las víctimas silenciadas y sus madres patologizadas y criminalizadas por el poder judicial, que se convierte en un instrumento de tortura y revictimización para las víctimas y en garante de la impunidad de los victimarios. Se perpetúa el continuum de violencia en el que madres e hijas/os permanecen infinitamente. En el presente artículo examinaremos las prácticas de crueldad a la que son sometidos los niños, niñas y adolescentes y sus madres protectoras por parte de un sistema institucional aliado a los agresores con el fin de restaurar el poder patriarcal en la familia.
La alienación de la sociedad con respecto al incesto
Authors: De Angulo José Miguel , Losada Luz Stella
Published: September 2024

La sociedad y los gobiernos continúan minimizando el grave problema de salud pública de las agresiones sexuales contra niños, niñas y adolescentes, así las investigaciones evidencian su alta prevalencia y grave impacto en la vida de las víctimas y sus familias que quedan resquebrajadas y enfrentando grandes dificultades para reorganizar sus proyectos de vida. Las necesidades de los niños y niñas de contar con un apego los lleva a adaptase para sobrevivir a cualquier costo en familias con padres violentos así les destrocen su vida. Esta es una de las razones por las que la cultura del incesto se ha venido reproduciendo de generación en generación. La cultura del incesto es el conjunto de imaginarios, normas, regulaciones, roles y prácticas en la familia y sociedad que buscan normalizar el supuesto derecho de un varón adulto sobre los pensamientos, sentimientos, decisiones, el cuerpo e incluso las partes más íntimas de la vida emocional (su sexualidad) de otra persona, dejándola degradada y humillada viviendo con una falsa vergüenza, culpabilidad y sentido de impotencia durante su vida. Esta ha sido una estrategia muy efectiva para reproducir las relaciones de dominancia-subyugación entre hombres y mujeres en todos los aspectos de la sociedad. Dos factores descomponen a una sociedad: el silencio ante la comisión de delitos y la complicidad para que queden impunes, arropados en redes de corrupción social y gubernamental. En ningún otro delito estos dos factores están tan presentes como en los cometidos encubiertamente en las familias impregnadas por la cultura del incesto.
Machine Learning Application in Drug Discovery
Authors: Ugurlu Sadettin Yavuz
Published: September 2024

Integrating machine learning (ML) into drug discovery has ushered in a new era of innovation, dramatically enhancing the efficiency and precision of identifying and developing new therapeutics. This review provides a comprehensive analysis of the current applications of machine learning in drug discovery, focusing on its transformative impact across various stages of the drug development pipeline. We delve into key ML methodologies, including supervised and unsupervised learning, neural networks, and reinforcement learning, examining their underlying principles and specific contributions to drug discovery processes. By exploring case studies and recent advancements, this review illustrates how ML algorithms have been utilized to predict drug-target interactions, optimize drug design, and streamline clinical trial processes. Furthermore, we discuss the challenges and limitations of implementing ML techniques in this field and highlight emerging trends and future directions. This review aims to offer researchers a thorough understanding of ML's potential to revolutionize drug discovery and equip them with the insights needed to leverage these technologies effectively.
Electronic Effects of Bidentate P,N-Ligands on the Elementary Steps of Au(I)/Au(III) Reactions Relevant to Cross-Coupling Chemistry
Authors: Treacy Joseph , Chao Elaine , Kunkel Grace , Louis-Goff Thomas , Tilden James , Spokoyny Alexander , Maynard Heather , Houk Kendall
Published: September 2024

Oxidant-free Au(I)/Au(III) catalyzed cross-coupling has been recently enabled by the use of bidentate P,N-ligands. To further develop these P,N-ligands, computational studies were performed to understand their effects on the oxidative addition of aryl iodide electrophiles with Au(I). Using this mechanistic understanding, six new, electron rich P,N-ligands were synthesized. The ligand exchange equilibrium and reductive elimination were then characterized using an Au(III)-mediated S-arylation reaction. The results detailed herein provide new fundamental insights in Au(I)/Au(III) ligand design.
Sulfenylnitrene-Mediated Nitrogen-Atom Insertion into Pyrroles, Indoles, and Imidazoles
Authors: Ghosh Bidhan , Kafle Prakash , Mukherjee Rishav , Welles Randall , Herndon Deacon , Nicholas Kenneth , Shao Yihan , Sharma Indrajeet
Published: September 2024

Given the prevalence of nitrogen-containing heterocycles in FDA-approved drugs, selectively incorporating a single nitrogen atom emerges as a promising scaffold-hopping approach to enhance chemical diversity in drug discovery libraries. In this study, we harness the distinct reactivity of sulfenylnitrenes, which insert a single nitrogen atom to transform readily available pyrroles, indoles, and imidazoles into synthetically challenging pyrimidines, quinazolines, and triazines, respectively. Our additive-free method for skeletal editing employs easily accessible, benchtop-stable sulfenylnitrene precursors over a broad temperature range (–30 to 150 ºC). This chemical approach is compatible with diverse functional groups, including oxidation-sensitive functionalities like phenols and thioethers, and has been applied to various natural products, amino acids, and pharmaceuticals. Furthermore, we have conducted mechanistic studies and explored regioselectivity outcomes through DFT calculations.
Investigation of metallacages for cisplatin encapsulation using Density Functional Theory (DFT)
Authors: Ugurlu Sadettin Yavuz
Published: September 2024

Cancer is highly complex, including cross-talks between signalling pathways and multiple genes. Fortunately, successful anti-cancer drugs, such as cisplatin, are promising to treat cancer. Despite its clinical success, cisplatin presents several issues, including neurotoxicity, ototoxicity, nephrotoxicity and drug resistance. These limitations of the successful anti-cancer cisplatin can be overcome with the help of novel supramolecular drug delivery systems. This research aims to optimise novel supramolecular drug delivery systems – metallacage (M2L4}(M = metal, L = ligand) – that can be used to encapsulate cisplatin to protect it from metabolism. Specifically, we investigated the shape and stability of ten metallacages using different metals: Pt2+, Pd2+, Ni2+, Cu2+ and Au3+ using Density Functional Theory (DFT) methods to encapsulate one or two cisplatin molecules. Thus, we applied WebMo running PBE0 and Hartree Fock as theories, with LanL2DZ as a basis set. The results demonstrate that PBE0/LanL2DZ is the best method to describe the cages. The results show that Endo-N Ni2L4 and Endo-N Cu2L4 cages are the best option to encapsulate one and two cisplatin, while the least suitable system is Endo-C Pt2L4 and Endo-C Au2L4 for cisplatin encapsulation. Furthermore, endo-C cages are farther from ground state energy because of their higher energy than endo-N cages. Therefore, endo-N cages are superior to endo-C cages for the encapsulation of cisplatin.
Enseñanza del inglés en contextos de interculturalidad
Authors: Klenner Maura , Gacitúa Sandra
Published: September 2024

Este texto aborda, mediante la presentación de trabajos de investigación pedagógica, el contexto y los factores que confluyen en la enseñanza del inglés en el contexto local. La primera parte de este libro aborda el concepto de competencia comunicativa intercultural, presentando enfoques y modelos en el capítulo 1, y en el capítulo 2, las concepciones que un grupo de docentes de La Araucanía tienen respecto del desarrollo de ésta. En la segunda parte del libro, se abordan diversos contextos y experiencias pedagógicas asociadas a la experiencia intercultural. Dichos contextos y experiencias fueron relevados por estudiantes de Pedagogía en Inglés de la Universidad de La Frontera como parte de su trabajo de investigación pedagógica conducente al grado de Licenciado en Educación. La tercera parte, presenta teorías sobre el abordaje del desarrollo de la comprensión lectora y producción escrita en contextos interculturales y propuestas metodológicas para a el desarrollo de la competencia comunicativa en la clase de inglés. El objetivo de esta publicación es contribuir a la comprensión de los escenarios en los que ocurre la enseñanza del inglés en contextos de interculturalidad, a la vez de proponer aproximaciones metodológicas concretas para el desarrollo de la comprensión lectora, tomando como base las experiencias y relatos propios de la cultura mapuche. Este material será de utilidad tanto para profesores de inglés en formación, como para profesores en ejercicio.
An Exploration of (Area-based) Social Inclusion and Community Development Training Programmes in Ireland
Authors: McGuinness Seamus , Bergin Adele , Whelan Adele
Published: September 2024

This report examines training interventions provided in 2014 by the Local and Community Development Programme, now known as the Social Inclusion and Community Activation Programme (SICAP).
History of the Genesis and Development of Pentecostalism in Western Siberia
Authors:   Transbaikal State University, Savvateeva T. A. , Kondakova N. S. ,   Transbaikal State University
Published: September 2024

The article is devoted to the history of Pentecostal spiritual awakening in Siberia, Russia. It includes information about the first missionaries from Belorussia and describes the further continuing of Pentecostal movement in Baikal region and its transformation till our time. The authors analyzed this period of time of 33 years, the difficulties which the church faced in the post-Soviet Union society. The information presented were taken from the Pentecostal church’s “Salvation in Christ” archive, local newspapers, the interviews with senior pastor of the church “Salvation in Christ” Chita. The arguments we have presented in the article prove that Pentecostal ministry have changed under the influence of Siberian native culture. The church has responded the people’s needs. That made this kind of Chistian faith so attractive for local residents. That’s why Pentecostal church remains the fastest growing Christian denomination in Russia. Research methods: diachronic, historical, dialectical.
The Image of the Pastoral Civilization in the Biblical Texts as Evidence of the Peculiarities of the Process of Historical Development of the Abrahamic Cvilization
Authors:   Kazan (Volga Region) Federal University, Gorin A. A.
Published: September 2024

In the article, the author raises the question of the possibility of using sacred texts (the Old and New Testaments) as a historical source reflecting not only the history of mankind receiving divine Revelation, not only reliably describing the objective reality of the Biblical period of history. The author also raises the question of the texts of historical books of the Old Testament as a source of data on civilizational markers that contribute to determining the moments of qualitative evolutionary growth of ancient civilizations. In the long term, the author suggests using the results of the work not only to consider the dynamics of the development of Abrahamic cultures, but also to evaluate modern attempts to create alternative Abrahamic teachings to Christian, both those that failed to move to a supranational level of development and those claiming this perspective. As an example of such a marker, the author considers the phenomenon of pastoral culture reflected in the Old Testament texts, as well as in the texts of the New Testament. The author approaches the assessment of this marker from the perspective of interdisciplinary analysis, simultaneously involving both sacred texts and research by secular scientists in the field of the history of the Ancient East, biblical archaeology, and the history of religions. Considering the manifestations of the marker under study, the author makes an attempt to evaluate it in the context of the general historical development of both the Abrahamic civilization and the civilizations that influenced the formation of the Jewish civilization in the era of Antiquity. The author traces the process of changing the content component at the moment when the Abrahamic civilization reaches a qualitatively new Christian level. From the author's point of view, similar changes occur with each of the complex of markers characterizing the Abrahamic civilization throughout all successive stages of its development.
Problems of Legal Regulation of Religious Feelings of Believers in the Russian Federation: Causes, Consequences and Solutions
Authors:   Kazan (Volga Region) Federal University, Shakirov A. F. ,   Regional Management Center of the Republic of Tatarstan
Published: September 2024

This article explores the concept of insulting religious feelings and its manifestation in the social space, as well as analyzes various aspects of this phenomenon, including its definition, possible consequences and social significance. Legal aspects related to the protection of religious feelings, including laws and legal norms in the Russian Federation, are touched upon. The importance of the socio-cultural context and its influence on the perception of insulting religious feelings in Russian society is emphasized. The social consequences of the introduction of criminal liability for insulting religious feelings in Russia are being established. The article considers the negative experience of the lack of law enforcement practice for the defense of religious feelings of believers on the example of the French Republic. Special attention is paid to reflecting the concept of religious feelings of believers as a complex and multifaceted concept, the protection of which must maintain a balance between human rights to freedom of expression and respect for other people's religious beliefs. The question of the possibility of expressing the concept of "religious feeling of believers" as a subject of legal regulation is considered. The existing problems of the terminological apparatus are noted, and an attempt is made to classify actions aimed at insulting religious feelings, according to the law enforcement practice in the Russian Federation.
Trends in the Distribution of Presidential Grants in Russia: Socio-Political Priorities and Regional Features of the Development of the Non-Profit Sector
Authors:   P. G. Demidov Yaroslavl State University, Krainova N. V. , Prusov D. A. ,   P.G. Demidov Yaroslavl State University
Published: September 2024

The article presents the results of a study in which projects for obtaining presidential grants were considered as specific indicators of socially significant issues in the subjects of the Russian Federation. The aim of the work was to identify the dynamics of changes in the distribution of applications by thematic directions, as well as to establish the level of correlation between the grant direction and the number of winners. According to the statistical data obtained, there is an increase in the number of participants in the competition for federal funding for projects. Moreover, the most significant directions for financial support are “Healthcare, promotion of a healthy lifestyle”, “Social services, social support, and protection of citizens”, and “Preservation of historical memory”, the share of winners in which is high. It is important to note that this trend can be extrapolated to the regional level, as evidenced by the data from a comparative analysis of the best Russian regions in supporting and developing the local nonprofit sector. Additionally, it is noteworthy that the mathematical calculations did not establish a correlation between the thematic direction and the number of applications for funding, but a strong correlation was found between the number of registered nonprofit organizations in the Russian region and the number of winners.
About Indo-Pacific Strategy of the United States
Authors:   Irkutsk State University, Puzynya N. N.
Published: September 2024

The article is devoted to the analysis of the fundamental document of the administration of US President Joseph Biden, which defines the key directions of the United States' struggle for the Indo-Pacific region. This area of the globe has long been recognized by American leaders as vital to the security and prosperity of the United States. The content of the work involves the study of the main aspects of the theory and practice of preparing the United States for the fight for the IndoPacific region, the intended goals and main directions for the implementation of this strategy during the immediate period after the publication of the document. Based on an analysis of the text of the document, an attempt has been made to trace the continuity of the views of the current American leadership on the content of the country’s policy in this region in conceptual terms, as well as the features of its implementation in practice, taking into account the modern specifics and the readiness of the US allies and partners in the region for such a turn of events. It is concluded that the serious strategic ambitions of the American administration are based on the belief that in the near future no region will be more important for the United States than the Indo-Pacific region. The results of the study are relevant in the context of determining options for possible US actions in the IPR.
The Relationship Between Self-Efficacy and Self-Care Management with the Quality of Life of Patients With Diabetes Mellitus
Authors: Puspita Widya Galih , Wijayanti Anisa Catur
Published: September 2024

Diabetes Mellitus (DM) is a disease that suffers for years and even throughout life. DM patients have the possibility of experiencing various kinds of complications that hurt their quality of life. Factors that affect the quality of life include characteristic respondent (family history, gender, age, long-suffering of DM), self-efficacy, and self-care management. This study analyzed the relationship between self-efficacy and self-care management and the quality of life of DM patients. This quantitative study used an analytical observational approach using a cross-sectional study design with a sample size of 180 respondents, determined by a purposive sampling technique. Data was collected from respondents using a questionnaire. The research data were analyzed using logistic regression. There is a relationship between self-efficacy (p-value = 0.003) with OR (95% CI) = 7.108 (1.981 – 25.510) and self-care management (p-value 0.024) with OR (95% CI) = 3.703 (1.190 – 11.525) with quality-of-life DM patients. This study recommends that structural education programs and increased social support improve self-efficacy and self-care management to impact the quality of life of DM patients positively.
The Effect of Andaliman Fruit Extract on the Incision Wound Healing the Wistar Male White Rats and Collagen Type III
Authors: Intan Hasibuan Febria Nurul , Chiuman Linda , Fachrial Edy
Published: September 2024

The extract of andaliman fruit has antimicrobial activity. The active compounds of andaliman fruit are believed to positively contribute to human health, one of which is flavonoids, which can improve the wound healing process because of their function as an antioxidant and anti-inflammatory. This study aims to determine the effect of giving ethanol extract of andaliman fruit on the healing process of incision wounds in Wistar strain white rats and collagen type III. This research is an experimental posttest-only controlled group design. This study used five groups: NaCL treatment, betadine treatment, 1% andaliman ethanol extract treatment, 3% andaliman ethanol extract treatment, and 5% andaliman ethanol extract treatment, where each group had six rats. Data analysis used normality tests, homogeneity tests, and ANOVA tests. The results showed that the ethanol extract of andaliman fruit contains several active compounds such as alkaloids, saponins, tannins, and glycosides. The fastest incision wound healing was the fourth test group, the test group with 3% andaliman fruit ethanol extract treatment on day 14, with an average length of incision wound healing of 3.44mm. The 3% andaliman ethanol extract had the potential to accelerate wound healing activity.
THE ROLE OF HOTEL MANAGERS IN ENHANCING SUSTAINABLE DEVELOPMENT IN LEBANON
Authors: Chanab Rayan Abou , Younis Joumana
Published: September 2024

Objective: This study addresses the issue of corporate social responsibility with a special focus on Lebanese 5 star hotels. Point that a sustainable development approach has implications on organizational actions and strategies, recognize the role of managers in Lebanese hotels in applying and implementing sustainable development principles, and indicate the changes that occur in each department of the organization after the adoption of the CSR foundation.
 
Theoretical Framework: This topic presents the main concepts on which the research is based. It highlights everything related to sustainable development, corporate social responsibility and the role of managers, providing a solid foundation for understanding the research context.
 
Method: The focus is on critical realist philosophy and positivism, with qualitative analysis and inductive reasoning through observation and semi-structured interviews. Secondary data come from books, published and unpublished personal sources, newspapers, websites, blogs, diaries, government documents, and podcasts.
Results and Discussion: The data collected show that the concept of sustainable development exists in Lebanon and that Lebanese hotels have become socially responsible, albeit to varying degrees. Managers have a key role to play in realizing this concept.
 
Research Implications: The practical and theoretical implications of this research were discussed, providing an accurate snapshot of the level of implementation of sustainable development in Lebanese hotels. It provides an information base, the application of which helps to raise the level of implementation of the concept of sustainability in hotels.
 
Originality/Value: The importance of the study lies in providing information on all the study variables, clarifying the role of managers in applying the concept of CSR, and highlighting the basic and sequential steps for applying CSR in Lebanese hotels.
Digital Dexterity
Authors:   , Duffy Svenya
Published: September 2024

In everyday life, hands play a vital role in our functionality, extending into the virtual world where they are increasingly becoming controllers. Precisely detecting finger movement, known as hand posture sensing, is crucial for the translation from physical movement to a matching digital one. Current approaches rely on sensors integrated into gloves, yet issues appear with longevity, accuracy, and positioning. This research investigates whether three-dimensional (3D) printing can address these challenges, leveraging its accessibility and rapid iteration capabilities, particularly with advancements like printing directly onto fabric and integrating electronics. With a Research Through Design approach supported by iterative and criteria-based methods, the project can evolve dynamically. Added 3D printed structural modifications enhance sensor placement and protection, address accuracy concerns, and pave the way for bespoke, market-ready products. This project's application involves integrating these explorations into an augmented reality experience, specifically for playing musical instruments, opening up new possibilities for immersive interactions in virtual environments.
Beyond Tolerance
Authors:   , Japi Zin Zain Zikry
Published: September 2024

As cities worldwide experience rapid growth and increasing density due to urban migration, designers face the challenge of addressing intensification while meeting the needs of diverse cultural and ethnic groups. While existing literature in Landscape Architecture and Urban Design emphasizes the importance of social cohesion for urban communities, it often relies on conventional design guidelines that prescribe sociality in urban environments. This thesis diverges from traditional approaches by employing assemblage theory and a focus on involuntary human perceptions in space.

Through the exploration of dynamic spatial relationships and bodily interactions within urban environments, this research develops design strategies aimed at fostering social synergies and promoting interactions in public spaces. By understanding how urban environments shape perceptions and behaviors, the study proposes strategies that depart from prescriptive guidelines, instead focusing on revealing and enhancing the inherent potential within each site to facilitate social synergies.

The culmination of this research is a set of strategies that enable individuals to discover and utilize the hidden potentials within landscapes. These strategies are validated through site-specific testing and iterative design processes, which elucidate their effectiveness, limitations, and implementation procedures for fostering social synergies in urban spaces.

This thesis contributes to the discourse on Landscape Architecture and Urban Design by offering strategies that empower designers to engage with and shape their environments, fostering inclusive and vibrant urban spaces that reflect the diverse needs and experiences of their inhabitants.
The Relationship Between NLRP3 Inflammasome and Its Downstream Inflammatory Factors in Obstructive Sleep Apnea Patients with Carotid Atherosclerosis Under Cigarette Exposure
Authors: Lv Qian , Yu Qiaoli , Wei Lihua , Su Jili , Zhou Yan
Published: September 2024

Aim: To study the relationship between NLRP3 (nucleotide oligomerization domain [NOD]-, leucine-rich repeats [LRR]-, and pyrin domain-containing protein 3) inflammasome and its downstream inflammatory factors in obstructive sleep apnea (OSA) patients with carotid atherosclerosis (CAS) under cigarette exposure, further exploring the risk factors of CAS in OSA patients. Methods: A total of 109 adult males who underwent polysomnography and carotid artery ultrasonography in our hospital from October 2019 to December 2021 were selected. According to the detection results, they were divided into the OSA group, the CAS group, and the OSA combined CAS group; additionally, 29 healthy subjects who underwent a physical examination were also included. According to whether they were smoking, the groups were further divided into smoking and non-smoking groups. The age, body mass index (BMI), blood pressure, apnea-hypopnea index (AHI), lowest blood oxygen saturation (LSaO2), carotid intima-media thickness (CIMT), levels of blood sugar, blood low-density lipoprotein cholesterol (LDLc), and serum NLRP3, interleukin-1β (IL-1β), and interleukin-18 (IL-18) of all subjects were recorded. Results: The OSA combined CAS group had higher LDLc levels and AHI and lower LSaO2 than the OSA group and CAS group. The levels of serum NLRP3, IL-1β, and IL-18 in the OSA group were higher than those in the normal control group (P < 0.05); and those in the OSA combined CAS group were higher than the OSA group and CAS group (P < 0.05), regardless of cigarette exposure. Considering cigarette exposure, serum NLRP3, IL-1β, and IL-18 levels were higher in the OSA, CAS, and OSA combined CAS smoking groups than those in the non-smoking group (P < 0.05). Under cigarette exposure, AHI, LDLc, NLRP3, IL-1β, and IL-18 were significantly positively correlated (P < 0.05), and LSaO2 was negatively correlated with CAS in OSA (P < 0.05). AHI, LSaO2, LDLc, NLRP3, and IL-1β are the risk factors for OSA combined with CAS. Conclusion: LSaO2, AHI, LDLc, NLRP3, and IL-1β are the important risk factors for OSA combined with CAS under cigarette exposure, and their levels can be used to predict the occurrence of CAS in OSA.
Evaluation of the Clinical Efficacy of Chuzhi Shengfa Tablets and Finasteride in the Treatment of Androgenetic Alopecia
Authors: Wei Jianming , Li Yu , Zhang Li , Wang Rui , Chen Lu , Zhao Jiaojiao , Li Jia
Published: September 2024

Objective: To explore the clinical efficacy and safety of Chuzhi Shengfa tablets combined with finasteride in the treatment of male androgenetic alopecia (AGA). Methods: Sixty male patients with androgenetic alopecia admitted to our Department of Dermatology between January 2022 and January 2024 were randomly divided into two groups, with 30 patients in each group. The control group was treated with finasteride, while the observation group received a combination of Chuzhi Shengfa tablets and finasteride. The clinical efficacy and adverse reactions in both groups were compared. Results: The overall effectiveness rate in the observation group was 93.33% (28/30), significantly higher than the control group’s 73.33% (22/30), with a statistically significant difference (P < 0.05). There was no statistically significant difference in the incidence of adverse reactions between the two groups (P > 0.05). Conclusion: The combination of Chuzhi Shengfa tablets and finasteride shows good clinical efficacy in treating male androgenetic alopecia. Additionally, Chuzhi Shengfa tablets are convenient to administer and effectively improve efficacy, significantly improving patients’ conditions, and demonstrating good clinical application value.
Exploration and Application of the Flipped Classroom Based on Outcome-Oriented Educational Principles in Vocational Nursing Practical Training
Authors: Wei Huan , Li Dan
Published: September 2024

Purpose: To explore the practical effects of using the flipped classroom approach based on outcome-oriented educational concepts in nursing practical training at vocational colleges. Methods: From February 2023 to February 2024, a total of 62 nursing trainees from our school were sampled and randomly divided into a study group and a control group using a randomized controlled trial design, with 31 students in each group. The control group received conventional training, while the study group received practical training based on the outcome-oriented educational concept in flipped classrooms. Comparison was made between the two groups on assessment scores, teaching satisfaction, and self-directed learning ability ratings. Results: Statistical comparisons showed that the study group’s assessment scores, teaching satisfaction, and self-directed learning ability ratings were significantly higher than those of the control group (P < 0.05). Conclusion: The flipped classroom model based on outcome-oriented educational concepts in nursing practical training at vocational colleges can improve students’ assessment scores and self-directed learning abilities, and enhance teaching satisfaction, demonstrating potential for wider application and dissemination.
The Relationship Between Social Isolation and Psychological Well-Being Among Older Adults in the Community
Authors: Liu Weihua , Li Yanling , Wang Xiaoxing , Yan Lijing , Wang Fengwan , Wang Ying
Published: September 2024

Objective: To investigate the psychological well-being of the elderly in Baoding City, Hebei Province, and analyze its influencing factors, with a focus on exploring the relationship between social isolation and psychological well-being. This study aims to provide a reference for effective interventions that promote the physical and mental health of elderly individuals in the community. Methods: A total of 265 elderly individuals from six communities in Baoding City, Hebei Province were surveyed between November 2023 and March 2024 using the general information questionnaire, the Social Isolation Scale for the Elderly, and the Comprehensive Happiness Questionnaire. Results: The total score of the Social Isolation Scale for the elderly in the community was (14.15 ± 3.73) points, indicating a moderate level of social isolation. The average score of P50 on the Psychological Well-being Scale was 4.88, suggesting that the psychological well-being of the elderly in the community was moderate to high. Multivariate regression analysis showed that the level of social isolation significantly influenced the psychological well-being of the elderly (P < 0.05), with social isolation negatively correlated with psychological well-being. Conclusion: Healthcare professionals should pay attention to the social isolation of elderly individuals in the community and develop targeted interventions to improve their psychological well-being and quality of life.
Comparison of Antibacterial Activities of Six Bacillus amyloliquefaciens Strains
Authors: Liao Jiedan , Chen Yingwen , Lin Yuchao , Wei Junxiang , Gao Hongyu , Liu Yuchen , Gu Wanjun , Xie Zhiheng , Zhou Shuzhen
Published: September 2024

In this study, six bacterial strains were isolated from the sediment, probiotic fermentation products, and lake sediments, they were identified as Bacillus amyloliquefaciens using genetic evolution analysis, which were named B3, B4, B5, XD3, YF6, and YF8. The comparison of the antibacterial activity, hemolytic activity, and antibiotic sensitivity of six Bacillus amyloliquefaciens strains laid a foundation for the development and application of antimicrobial peptide products. A surface activity assay was used to determine the production of biosurfactants in six Bacillus amyloliquefaciens strains. With Staphylococcus aureus and Escherichia coli as indicator bacteria, their antibacterial activity was determined using the agar diffusion method; the same diffusion method was used to determine the antibiotic susceptibility of Bacillus amyloliquefaciens. The results showed that the six Bacillus amyloliquefaciens strains had obvious biosurface activity, and the bacteria inhibited Staphylococcus aureus and Escherichia coli, from strong to weak: YF8, XD3, B3, B4, YF6, and B5. Strain YF8 had the best broad-spectrum bacteriostatic effect, followed by strain XD3. All Bacillus amyloliquefaciens strains were susceptible to 16 common drugs, except for Bacillus amyloliquefaciens strain YF8, which was intermediate to neomycin. The study shows that Bacillus amyloliquefaciens and secondary metabolites have the ability to produce a variety of active peptides, exert a certain inhibitory effect on common pathogens, and have the potential to develop as animal probiotics.
The Role of MSCT in Evaluating Tumor Size, Density, Immunohistochemical Classification, and Pathological Risk in GIST Patients
Authors: Luo Yi , Li Jiaman , Chen Pengman , Huang Junmao , Yi Shuisheng , Chen Xinliang , Wen Zhenfeng
Published: September 2024

Objective: To investigate the role of multilayer spiral CT (MSCT) in evaluating patients with gastrointestinal stromal tumors (GIST), particularly its utility in determining tumor size, immunohistochemical classification, and pathological risk. Methods: A retrospective analysis was conducted on 22 GIST patients, confirmed by surgical pathology between January 2019 and December 2023. All patients underwent MSCT examination prior to surgery. Tumor size, density, and immunohistochemical classification from the MSCT results were compared with the postoperative pathological findings. Additionally, the ability of MSCT to predict GIST risk grade was evaluated in combination with immunohistochemical analysis results. Results: No significant differences were found between the preoperative MSCT findings and postoperative pathological results in terms of tumor size, density, or immunohistochemical classification in GIST patients. MSCT also enhanced the ability to predict GIST risk grades. Conclusion: MSCT demonstrates significant clinical value in the diagnosis and risk assessment of GIST, aiding in the prediction of the tumor’s biological behavior and patients’ treatment responses.
Corrigendum: EGFR Mutation and FHIT Methylation: Inverse Relationship in Patients with Lung Adenocarcinoma and Tuberculosis
Authors: Abudureheman Mireguli , Yan Xiuyou , Ainitu Baidurula
Published: September 2024

Correction
The funding in the original publication (https://www.doi.org/10.26689/par.v8i2.6444) is incorrect. The original funding was:
The Ethnic Minority Science and Technology Program of Xinjiang Autonomous Region (201523122)
 
The correct funding should be as follows:
This project was supported by Natural Science Foundation of Xinjiang Uygur Autonomous Region (2020D01A107)
Effect of Jianpi Wenshen Granules on the Nutritional Control Status Score in Elderly Patients Undergoing Maintenance Hemodialysis
Authors: Ye Hailiang , Ma Teng , Zhou Yan , Li Taoli , Zhu Hong
Published: September 2024

Objective: To explore the effect of Jianpi Wenshen Granules on the Controlling Nutritional Status (CONUT) score in elderly patients undergoing maintenance hemodialysis. Methods: Seventy elderly outpatients undergoing maintenance hemodialysis from January 2023 to January 2024 at the Blood Purification Centers of Taizhou Traditional Chinese Medicine Hospital and Taizhou Second People’s Hospital were selected as the study subjects. The patients were randomly divided into two groups: the study group and the control group, with 35 patients in each group. Both groups received maintenance hemodialysis, while the control group received only conventional Western medicine treatment, and the study group was additionally treated with Jianpi Wenshen Granules. The changes in biochemical and inflammatory markers before and after treatment were compared between the two groups. The nutritional status of the patients was assessed using the Controlling Nutritional Status (CONUT) score, and detailed statistics were gathered on anemia and albumin levels in both groups. Results: After treatment, the CONUT score in the study group significantly decreased compared to the control group, showing a significant correlation (P < 0.05). Albumin and hemoglobin levels significantly increased, with a notable difference (P < 0.05). There were no significant differences in alanine aminotransferase and aspartate aminotransferase levels between the two groups before and after treatment (P > 0.05). Conclusion: In elderly patients undergoing maintenance hemodialysis, Jianpi Wenshen Granules improve the CONUT score and enhance nutritional status, demonstrating potential for clinical application and promotion.
Castration Punishment for Sex Offenders: Reproductive Health Science Review
Authors: Riris Anak Agung Istri Dalem Cinthya , Wirenviona Rima , Kustantina Abadiyah Zakiah
Published: September 2024

Sexual crime is a form of crime in a society whose development is increasing based on their motives, traits, form, intensity, and modes. Women and children are subjected to victims of sexual crimes. The increase in sexual crimes caused the government to regulate castration punishment for sex offenders. Castration in health is surgery on the reproductive organs or using certain chemicals to reduce and eliminate sexual drive in men. The implementation of chemical castration in Indonesia is expected to have a deterrent effect on the perpetrators and prevent new cases of sexual violence. On the other hand, the implementation of chemical castration is thought to be against human rights. Related to the reproductive health perspective, castration as punishment can cause a decreasing reproductive function to come into sexual desire. Behavior aberration is a form of integrated multifactorial motives and the reason will not always biological factor or sexual drive. This article discusses the handling of sexual crimes that are comprehensively studied, especially in the area of reproductive health.
PENERAPAN MODEL PROBLEM BASED LEARNING MELALUI MEDIA FLEADIO UNTUK MENINGKATKAN KEMAMPUAN MEMBACA DAN MENULIS SISWA TUNANETRA KELAS VI SDLB PURWOSARI
Authors: Wulandari Sri , Uliyanti Ilana Anggita , Maharani Virka Arditya Pramesti , Aisyah Silviana , Ruby Arcivid Chorynia
Published: September 2024

Membaca dan menulis merupakan dasar kemampuan seorang peserta didik dalam dunia pendidikan. Dengan membaca seorang peserta didik mampu memperoleh informasi menggunakan media kata sedangkan menulis membuat seorang peserta didik mampu mentransformasikan gagasan melalui tulisan yang dapat dibaca oleh orang lain. Selain pada peserta didik normal, membaca dan menulis juga menjadi kemampuan yang harus dimiliki oleh anak inklusi. Penelitian ini bertujuan untuk mencari permasalahan yang berada pada SDLB Purwosari yaitu untuk mengetahui peningkatan kemampuan membaca dan menulis melalui media FLEADIO (flashcard braille animals dan audio) pada anak tunanetra. Penelitian menggunakan metode quasi eksperimen dan dibantu dengan adanya model pembelajaran problem based learning. Teknik pengumpulan data yang dilakukan dalam penelitian ini dengan observasi, wawancara dan tes unjuk kerja. Analisis data yang digunakan di dalam penelitian ini menggunakan statistik deskriptif sederhana. Pada penelitian ini, peneliti hanya menggunakan 1 orang peserta didik sebagai subjek penelitian yaitu peserta didik kelas VI SDLB Purwosari. Hasil dari penelitian ini yaitu adanya peningkatan kemampuan membaca dan menulis melalui media FLEADIO (flashcard braille animals dan audio) pada anak tunanetra kelas VI SDLB Purwosari.
Tinjauan Keadilan terhadap Advokasi Masyarakat dalam program Desa Inklusif Disabilitas di Bah Sulung, Kabupaten Simalungun
Authors: Sihombing Helpin , Tampake Tony , Ludji Irene
Published: September 2024

Penyandang disabilitas masih belum menerima pelayanan yang optimal secara keseluruhan. Penyandang disabilitas perlu mendapatkan ruang keadilan dan kesejahteraan dari keluarga dan masyarakat. Penelitian ini bertujuan untuk menganalisis dan mengeksplorasi keadilan yang di terima penyandang disabilitas di Desa Bah Sulung melalui program desa inklusif disabilitas. Program desa inklusif disabilitas merupakan upaya dari gereja dan masyarakat melalui membentuk Posko RBM (Rehabilitasi Berbasis Masyarakat) di Desa Bah Sulung. Analisis data dilakukan secara deskriptif kualitatif. Dalam pengumpulan data penulis melakukan observasi dan wawancara serta studi literatur di Desa Bah Sulung untuk menyelidiki pemenuhan hak dan kesetaraan yang didapatkan penyandang disabilitas. Informan terdiri dari pengurus posko RBM, Kader RBM, keluarga penyandang difabel dan beberapa masyarakat di Desa Bah Sulung, Simalungun.  Hasil penelitian menunjukkan bahwa penyandang disabilitas dan keluarga mendapatkan penerimaan, kesetaraan, melalui pemberdayaan posko RBM. Penulis menggunakan perspektif dari John Rawls mengenai teori keadilan sebagai landasan untuk menganalisis masalah keadilan penyandang disabilitas dalam pemenuhan kesetaraan dan hak.
Kata Kunci: Penyandang Disabilitas, Keadilan, Rehabilitasi Berbasis Masyarakat, Desa inklusif Disabilitas.
Enfermería en Urgencias y Enfermería Clínica
Authors: Verduga Andrade Lidia Roxana , Salazar Calle Brigitte Katherine , Delgado Bernal Doris Susana , Moreira Parrales Christel Gema , Bello Castillo Maria Carmen , Lucas Tumbaco Ivone Julissa , Vera Pozo Alejandra Abigail , Caro Delgado Maria Eduvigis , Chila Reina Roxana María , Quimis Quijije Johana Elizabeth , Figueroa Andrade Jessica Mariuxi
Published: September 2024

La enfermería en urgencias y la enfermería clínica son dos áreas fundamentales dentro del campo de la enfermería que se encargan de brindar atención especializada a pacientes en situaciones críticas y en entornos clínicos, respectivamente. En la enfermería en urgencias, los profesionales de la salud se enfrentan a situaciones de emergencia donde se requiere una rápida intervención para estabilizar al paciente y brindarle el tratamiento adecuado. Estos enfermeros deben estar capacitados para manejar situaciones de alto estrés y adaptarse a entornos cambiantes y complejos. Por otro lado, la enfermería clínica se centra en el cuidado de pacientes en entornos hospitalarios o ambulatorios, brindando atención continua y especializada a personas con diversas condiciones de salud. Los enfermeros clínicos trabajan en estrecha colaboración con otros profesionales de la salud para garantizar el bienestar y la recuperación de los pacientes. Siendo ambas profesiones tanto la enfermería en urgencias y la enfermería clínica dos áreas clave de la enfermería que requieren habilidades especializadas, conocimientos técnicos y un fuerte compromiso con el cuidado de los pacientes.
Analysis of State Civil Response to Thematic Bureaucratic Reform Implementation and Perception
Authors: Sabtian Yoki Tulus , Natasha Catherine Eugene , Djati Dhefara Hersaning
Published: September 2024

Thematic bureaucratic reforms allow the government to focus more on addressing challenges in specific sectors so that the results can be felt directly by the public. This study aims to explore deeper responses, views, and perceptions of a small number of State Civil Apparatus (ASN) to the Thematic Bureaucratic Reform Reaction. The method used in this study is a qualitative study with an exploratory approach using an open questionnaire that allows respondents to provide narrative responses regarding their views, reactions, and perceptions of the reform program. The study was conducted in the Organization Section of Lampung Province as one of the OPD (Regional Apparatus Organization) that has implemented thematic bureaucratic reforms. The result obtained in this research is the lack of understanding of the State Civil Apparatus (ASN) regarding preparing the Thematic Bureaucratic Reform roadmap. However, civil servants have tried to compile the roadmap as a reference for preparing government programs. The involvement of civil servants in the preparation of the thematic bureaucratic reform roadmap has also been. What can be developed next is the existence of research or socialization related to how to technically prepare a thematic bureaucratic reform roadmap according to procedures so that it can be implemented properly.
Accountability and Transparency of Village Fund Management in Wonosalam Village
Authors: Amali Aditya Chisabul
Published: September 2024

Penelitian ini membahas tentang akuntabilitas dan transparansi pengelolaan dana desa di Desa Wonosalam Kabupaten Jombang. Desa Wonosalam memiliki potensi alam dan infrastruktur yang mendukung pembangunan, dengan penekanan pada akuntabilitas dan transparansi pengelolaan keuangan desa. Infografis digunakan untuk memperlihatkan pendapatan, pengeluaran, dan pembiayaan desa secara terbuka guna meningkatkan transparansi. Meskipun telah diupayakan dengan baik, masih terdapat ruang untuk peningkatan transparansi dan partisipasi masyarakat dalam pengelolaan keuangan desa. Metode studi pustaka digunakan sebagai pendekatan utama dalam penelitian ini. Daftar pustaka mencakup berbagai penelitian terkait pengembangan potensi desa, pengelolaan keuangan gereja, peran pengelolaan dana desa, dan pengelolaan BUM Desa. Referensi juga mencakup tata kelola, administrasi, akuntansi sektor publik, Undang-Undang Desa, dan Peraturan Menteri Dalam Negeri tentang pengelolaan keuangan desa. Dana desa merupakan bantuan dari pemerintah pusat untuk mendukung pembangunan dan pemberdayaan masyarakat desa. Pengelolaan dana desa harus mematuhi asas transparansi, akuntabilitas, partisipasi, dan keberlanjutan. Penelitian ini diharapkan dapat memberikan kontribusi dalam peningkatan akuntabilitas dan transparansi pengelolaan dana desa di Kabupaten Jombang, sekaligus memberikan masukan yang bermanfaat bagi pembangunan desa secara keseluruhan.