bluuebunny/crossref_metadata_2025 huggingface dataset:
Supplementary Table 1 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
Authors: Miyajima Naoto , Tsutsumi Shinji , Sourbier Carole , Beebe Kristin , Mollapour Mehdi , Rivas Candy , Yoshida Soichiro , Trepel Jane B. , Huang Ying , Tatokoro Manabu , Shinohara Nobuo , Nonomura Katsuya , Neckers Len
Published: April 2023

PDF file - 6K, Crizotinib and ganetespib synergistically inhibit colony growth of NIH3T3 cells expressing constitutively active, TKI-resistant MET (MET-Y1248H).
Supplementary Figure 3 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
Authors: Miyajima Naoto , Tsutsumi Shinji , Sourbier Carole , Beebe Kristin , Mollapour Mehdi , Rivas Candy , Yoshida Soichiro , Trepel Jane B. , Huang Ying , Tatokoro Manabu , Shinohara Nobuo , Nonomura Katsuya , Neckers Len
Published: April 2023

PDF file - 67K, Combination of crizotinib and ganetespib inhibits migration of wtMET-overexpressing cells.
Supplementary Figure 2 from The HSP90 Inhibitor Ganetespib Synergizes with the MET Kinase Inhibitor Crizotinib in both Crizotinib-Sensitive and -Resistant MET-Driven Tumor Models
Authors: Miyajima Naoto , Tsutsumi Shinji , Sourbier Carole , Beebe Kristin , Mollapour Mehdi , Rivas Candy , Yoshida Soichiro , Trepel Jane B. , Huang Ying , Tatokoro Manabu , Shinohara Nobuo , Nonomura Katsuya , Neckers Len
Published: April 2023

PDF file - 86K, Hsp90 stabilizes MET-Y1248H kinase activity and protects mutant MET from crizotnib inhibition in vitro.
Supplementary Figure 4 from LSECtin Expressed on Melanoma Cells Promotes Tumor Progression by Inhibiting Antitumor T-cell Responses
Authors: Xu Feng , Liu Jing , Liu Di , Liu Biao , Wang Min , Hu Zhiyuan , Du Xuemei , Tang Li , He Fuchu
Published: April 2023

PDF file - 150KB, Supplementary Figure 4 Validation of the specificity of anti-LSECtin.
Supplementary Methods from Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
Authors: Kalathil Suresh , Lugade Amit A. , Miller Austin , Iyer Renuka , Thanavala Yasmin
Published: April 2023

PDF file - 7K
Supplementary Figure 3 from Higher Frequencies of GARP+CTLA-4+Foxp3+ T Regulatory Cells and Myeloid-Derived Suppressor Cells in Hepatocellular Carcinoma Patients Are Associated with Impaired T-Cell Functionality
Authors: Kalathil Suresh , Lugade Amit A. , Miller Austin , Iyer Renuka , Thanavala Yasmin
Published: April 2023

PDF file - 175K, Supplementary Figure 3. Effect of chronic viral infection or pre-treatment of HCC patients on GARP and CTL-A4 expression.
Supplementary Figure 2 from Distinguishing between Benign and Malignant Melanocytic Nevi by In Vivo Multiphoton Microscopy
Authors: Balu Mihaela , Kelly Kristen M. , Zachary Christopher B. , Harris Ronald M. , Krasieva Tatiana B. , König Karsten , Durkin Anthony J. , Tromberg Bruce J.
Published: April 2023

PDF file - 171KB, Dysplastic nevus. (a) Clinical image (b) Histology image of the lesion showing melanocytes advanced in the upper epidermal layers (arrows). (c-d) MPM images of keratinocytes in epidermal layers at 25 microm (c) and 35 microm (d). Images show presence of melanocytic dendrites in the spinosum layer of epidermis (arrows). (e) MPM image of the basal layer showing cells with enlarged nuclei (arrows). Scale bar is 20 microm.
Supplementary Data from Novel Mechanism of Apoptosis Resistance in Cancer Mediated by Extracellular PAR-4
Authors: Burikhanov Ravshan , Shrestha-Bhattarai Tripti , Qiu Shirley , Shukla Nidhi , Hebbar Nikhil , Lele Subodh M. , Horbinski Craig , Rangnekar Vivek M.
Published: April 2023

PDF file - 3241KB, Figure S1. Apoptosis by extracellular Par-4 is augmented by NF-kappaB inhibition. Figure S2. UACA binds to Par-4 and is regulated by NF-kappaB. Figure S3. Correlation between nuclear NF-kappaB activity and UACA expression. Figure S4. Multiple RNA-interference approaches were used to knock down UACA in human cells to rule out off-target effects. Figure S5. Structure-function analysis of UACA. Figure S6. Vincristine sensitizes cells to apoptosis by extracellular Par-4. Figure S7. Model for inhibition of apoptosis by NF-kappaB at the proximal step of cell surface receptor expression. -Discussion -Methods
Supplementary Figure Legend from Distinct Effects of Ligand-Induced PDGFRα and PDGFRβ Signaling in the Human Rhabdomyosarcoma Tumor Cell and Stroma Cell Compartments
Authors: Ehnman Monika , Missiaglia Edoardo , Folestad Erika , Selfe Joanna , Strell Carina , Thway Khin , Brodin Bertha , Pietras Kristian , Shipley Janet , Östman Arne , Eriksson Ulf
Published: April 2023

PDF file - 78K
Supplementary Figures 1-10, Table 1 from Histone Deacetylase Inhibitor AR-42 Differentially Affects Cell-cycle Transit in Meningeal and Meningioma Cells, Potently Inhibiting NF2-Deficient Meningioma Growth
Authors: Burns Sarah S. , Akhmametyeva Elena M. , Oblinger Janet L. , Bush Matthew L. , Huang Jie , Senner Volker , Chen Ching-Shih , Jacob Abraham , Welling D. Bradley , Chang Long-Sheng
Published: April 2023

PDF file - 1.6MB, S1. The predicted truncated merlin protein was not detected in Ben-Men-1 cells. S2. IC50 determination of AR-42 in normal meningeal cells. S3. AR-42 treatment increased protein acetylation and decreased p-AKT. S4. Normal meningeal cells proliferate with a doubling time of about three days. S5. Ben-Men-1-LucB and parental Ben-Men-1 cells exhibit similar sensitivities to AR-42. S6. Intracranial NF2-deficient KT21-MG1 xenograft tumors demonstrated features of malignant meningiomas. S7. Ben-Men-1-LucB xenografts strongly expressed vimentin, amesenchymal marker for meningiomas. S8. AR-42 treatment caused tumor regression, whereas AR-12 treatment slowed tumor growth over time. S9. MRI detected a small tumor in a Ben-Men-1-LucB tumorbearing mouse treated with AR-42 for three months. S10. MRI did not detect the residual tumor in an AR-42-treated mouse after removal from AR-42 diet for six months.
Supplementary Figure Legend from CD103 or LFA-1 Engagement at the Immune Synapse between Cytotoxic T Cells and Tumor Cells Promotes Maturation and Regulates T-cell Effector Functions
Authors: Franciszkiewicz Katarzyna , Le Floc'h Audrey , Boutet Marie , Vergnon Isabelle , Schmitt Alain , Mami-Chouaib Fathia
Published: April 2023

PDF file - 9K
Supplementary Figure 1 from MicroRNA-Related Genetic Variants Associated with Clinical Outcomes in Early-Stage Non–Small Cell Lung Cancer Patients
Authors: Pu Xia , Roth Jack A. , Hildebrandt Michelle A.T. , Ye Yuanqing , Wei Hua , Minna John D. , Lippman Scott M. , Wu Xifeng
Published: April 2023

Supplementary Figure 1 PDF file - 122K, Supplementary figure 1 displays the histogram of p-value in bootstrap analysis
Supplementary Table 1 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 92K, Gene set enrichment analysis on the ten most statistically significant down-regulated metabolic pathways in SCAP loss-of-function cells.
Supplementary Figure 9 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: April 2023

PDF file - 140K, The effect of Fpr2 antagonists on the phenotype of WT mouse BM-derived macrophages
Supplementary Figure 7 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 106K, Knockdown of SCD1 does not alter cholesterol homeostasis.
Supplementary Figure 5 from Cell Surface Receptor FPR2 Promotes Antitumor Host Defense by Limiting M2 Polarization of Macrophages
Authors: Liu Ying , Chen Keqiang , Wang Chunyan , Gong Wanghua , Yoshimura Teizo , Liu Mingyong , Wang Ji Ming
Published: April 2023

PDF file - 70K, Production of chemokines by freshly isolated tumor cells
Supplementary Figure 1 from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 158K, Inhibition of lipogenic transcriptional program in various cancer cells.
Figure Legends from An Essential Requirement for the SCAP/SREBP Signaling Axis to Protect Cancer Cells from Lipotoxicity
Authors: Williams Kevin J. , Argus Joseph P. , Zhu Yue , Wilks Moses Q. , Marbois Beth N. , York Autumn G. , Kidani Yoko , Pourzia Alexandra L. , Akhavan David , Lisiero Dominique N. , Komisopoulou Evangelia , Henkin Amy H. , Soto Horacio , Chamberlain Brian T. , Vergnes Laurent , Jung Michael E. , Torres Jorge Z. , Liau Linda M. , Christofk Heather R. , Prins Robert M. , Mischel Paul S. , Reue Karen , Graeber Thomas G. , Bensinger Steven J.
Published: April 2023

PDF File - 118K, Legends for Supplementary Figures 1-8.
Supplementary Figure Legends 1-7 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: April 2023

PDF file - 72K, Full description of experimental procedures and results for supplementary figures
Supplementary Figure 7 from Bcl3 Selectively Promotes Metastasis of ERBB2-Driven Mammary Tumors
Authors: Wakefield Alison , Soukupova Jitka , Montagne Amelie , Ranger Jill , French Rhiannon , Muller William J. , Clarkson Richard W. E.
Published: April 2023

PDF file - 65K, Markers of epithelial-mesenchymal transition are unaffected by Bcl3 loss
Supplementary Tables 1 - 4 from miR-483-5p Promotes Invasion and Metastasis of Lung Adenocarcinoma by Targeting RhoGDI1 and ALCAM
Authors: Song Qiancheng , Xu Yuanfei , Yang Cuilan , Chen Zhenguo , Jia Chunhong , Chen Juan , Zhang Yue , Lai Pinglin , Fan Xiaorong , Zhou Xuan , Lin Jun , Li Ming , Ma Wenli , Luo Shenqiu , Bai Xiaochun
Published: April 2023

PDF file - 204KB, Supplementary Table 1. Clinicopathologic characteristics of lung adenocarcinoma patients. Supplementary Table 2. Correlation between the clinicopathological features and expression of miR-483-5p. Supplementary Table 3. Correlation between the tumor grades and the expression of proteins. Supplementary Table 4. Oligonucleotides used in this study.
Supplementary Methods from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Authors: Rahmani Mohamed , Aust Mandy Mayo , Attkisson Elisa , Williams David C. , Ferreira-Gonzalez Andrea , Grant Steven
Published: April 2023

PDF file - 64K, Primary antibodies and cell lines generation
Supplementary Figure Legend from Dual Inhibition of Bcl-2 and Bcl-xL Strikingly Enhances PI3K Inhibition-Induced Apoptosis in Human Myeloid Leukemia Cells through a GSK3- and Bim-Dependent Mechanism
Authors: Rahmani Mohamed , Aust Mandy Mayo , Attkisson Elisa , Williams David C. , Ferreira-Gonzalez Andrea , Grant Steven
Published: April 2023

PDF file - 85K
Supplementary Pairwise Interactions 2 from Collections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response
Authors: Masica David L. , Karchin Rachel
Published: April 2023

XLSX file - 835K
Supplementary Pairwise Interactions 1 from Collections of Simultaneously Altered Genes as Biomarkers of Cancer Cell Drug Response
Authors: Masica David L. , Karchin Rachel
Published: April 2023

XLSX file - 5261K
Supplementary Materials and Methods, Supplementary Figure Legends, and Supplementary Figures 1 through 5 from Mechanisms Promoting Escape from Mitotic Stress–Induced Tumor Cell Death
Authors: Sinnott Rebecca , Winters Leah , Larson Brittany , Mytsa Daniela , Taus Patrick , Cappell Kathryn M. , Whitehurst Angelique W.
Published: April 2023

PDF - 195K, Supplementary figure 1 displays micronucleation of paclitaxel resistant NSCLC cells, fate mapping of micronucleated HCC366 cells, and the scheme and full data set results from the pan-genomic screen. Supplementary figure 2 provides raw data for the plot in Figure 2A, mRNA levels following knockdown, off-target analysis and mitotic defects induced by top scoring siRNAs in additional paclitaxel resistant NSCLC cell lines. Supplementary figure 3 displays mitotic transit time and western blots for target depletion in Figure 2C and D, proliferation rates for HCC366 and HBEC3KT cells and HCC366 dose curve for proTAME. Supplementary figure 4 exhibits the frequency of CASC1 amplification in human tumors, quantitation of data presented in 3B, live cell imaging in cells depleted of CASC1 and tubulin changes in HBEC3KT cells following CASC1 depletion. Supplementary figure 5 displays TRIM69's protein structure, E3 ligase activity, association with pericentrin, impact on mitosis and tubulin polymerization and protein interaction network as well as a quantitation of Figure 5C.
Supplementary Figure Legend from Glioblastoma Stem Cells Are Regulated by Interleukin-8 Signaling in a Tumoral Perivascular Niche
Authors: Infanger David W. , Cho YouJin , Lopez Brina S. , Mohanan Sunish , Liu S. Chris , Gursel Demirkan , Boockvar John A. , Fischbach Claudia
Published: April 2023

PDF file - 26K
Supplementary Figure Legends from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: April 2023

PDF file - 107KB
Supplementary Figure 2 from KLF5 Regulates the Integrity and Oncogenicity of Intestinal Stem Cells
Authors: Nakaya Takeo , Ogawa Seishi , Manabe Ichiro , Tanaka Masami , Sanada Masashi , Sato Toshiro , Taketo Makoto M. , Nakao Kazuki , Clevers Hans , Fukayama Masashi , Kuroda Masahiko , Nagai Ryozo
Published: April 2023

PDF file - 123KB, mRNA expression signal intensities in stem cells of the duodenum of Lgr5 Cre+ Klf5flox/flox mice without Klf5 deletion (x-axis, log) and Lgr5 Cre+ Klf5delta/delta mice (with Klf5 2 deletion) (y-axis, log).
Suppl Table 2 from Neuromedin U: A Candidate Biomarker and Therapeutic Target to Predict and Overcome Resistance to HER-Tyrosine Kinase Inhibitors
Authors: Rani Sweta , Corcoran Claire , Shiels Liam , Germano Serena , Breslin Susan , Madden Stephen , McDermott Martina S. , Browne Brigid C. , O'Donovan Norma , Crown John , Gogarty Martina , Byrne Annette T. , O'Driscoll Lorraine
Published: April 2023

Suppl Table 2
Supplementary Figure 8 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: April 2023

PDF file - 80K, A model explaining the role of deltaNp63 expression in tumor initiation and tumor growth.
Supplementary Figure 7 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: April 2023

PDF file - 143K, Cell cycle analysis.
Supplementary Figure 4 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: April 2023

PDF file - 408K, deltaNp63alpha induces cell migration.
Supplementary Figure 2 from ΔNp63 Promotes Pediatric Neuroblastoma and Osteosarcoma by Regulating Tumor Angiogenesis
Authors: Bid Hemant K. , Roberts Ryan D. , Cam Maren , Audino Anthony , Kurmasheva Raushan T. , Lin Jiayuh , Houghton Peter J. , Cam Hakan
Published: April 2023

PDF file - 248K, Knockdown of endogenous deltaNp63 in JHU-011.
Supplementary Figures 1 - 6 from CHD7 Expression Predicts Survival Outcomes in Patients with Resected Pancreatic Cancer
Authors: Colbert Lauren E. , Petrova Aleksandra V. , Fisher Sarah B. , Pantazides Brooke G. , Madden Matthew Z. , Hardy Claire W. , Warren Matthew D. , Pan Yunfeng , Nagaraju Ganji P. , Liu Elaine A. , Saka Burcu , Hall William A. , Shelton Joseph W. , Gandhi Khanjan , Pauly Rini , Kowalski Jeanne , Kooby David A. , El-Rayes Bassel F. , Staley Charles A. , Adsay N. Volkan , Curran Walter J. , Landry Jerome C. , Maithel Shishir K. , Yu David S.
Published: April 2023

PDF file - 981KB, Representative Immunohistochemistry for CHD7 Expression in Primary Tumor Tissue (S1). Network Analysis via MetaCore ExPlain Process Network Analysis for genes involved in CHK1, CDC25A, AURKB, PLK1, HUS1 pathway (S2). CHD7 Knockdown Causes Gemcitabine Sensitization (S3). Mice with Xenograft Tumors Showed No Significant Difference in Body Weight (S4). CHD7 Knockdown Effect on Cell Cycle (S5). Gemcitabine Does Not Significantly Change CHD7 Protein Levels in Cells (S6).
Supplementary Figure 3 from Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer
Authors: Feigin Michael E. , Akshinthala S. Dipikaa , Araki Kiyomi , Rosenberg Avi Z. , Muthuswamy Lakshmi B. , Martin Bernard , Lehmann Brian D. , Berman Hal K. , Pietenpol Jennifer A. , Cardiff Robert D. , Muthuswamy Senthil K.
Published: April 2023

PDF file - 204K, Characterization of hSCRIBP305L tumors.
Supplementary Figure 2 from Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer
Authors: Feigin Michael E. , Akshinthala S. Dipikaa , Araki Kiyomi , Rosenberg Avi Z. , Muthuswamy Lakshmi B. , Martin Bernard , Lehmann Brian D. , Berman Hal K. , Pietenpol Jennifer A. , Cardiff Robert D. , Muthuswamy Senthil K.
Published: April 2023

PDF file - 187K, H&E staining of hyperplasia and tumors from hSCRIBP305L mice.
Supplementary Figure 1 from Mislocalization of the Cell Polarity Protein Scribble Promotes Mammary Tumorigenesis and Is Associated with Basal Breast Cancer
Authors: Feigin Michael E. , Akshinthala S. Dipikaa , Araki Kiyomi , Rosenberg Avi Z. , Muthuswamy Lakshmi B. , Martin Bernard , Lehmann Brian D. , Berman Hal K. , Pietenpol Jennifer A. , Cardiff Robert D. , Muthuswamy Senthil K.
Published: April 2023

PDF file - 99K, Expression of SCRIB mRNA in human breast cancer.
Supplementary Figure 2 from CUL3 and NRF2 Mutations Confer an NRF2 Activation Phenotype in a Sporadic Form of Papillary Renal Cell Carcinoma
Authors: Ooi Aikseng , Dykema Karl , Ansari Asif , Petillo David , Snider John , Kahnoski Richard , Anema John , Craig David , Carpten John , Teh Bin-Tean , Furge Kyle A.
Published: April 2023

PDF file - 727K, Dideoxynucleotide sequencing confirmed the presence of NRF2, CUL3, and SIRT1 mutations in case samples
Supplementary Figure Legend from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: April 2023

PDF file - 99K
Supplementary Figure 3 from Nitroreductase, a Near-Infrared Reporter Platform for In Vivo Time-Domain Optical Imaging of Metastatic Cancer
Authors: McCormack Emmet , Silden Elisabeth , West Richard M. , Pavlin Tina , Micklem David R. , Lorens James B. , Haug Bengt Erik , Cooper Michael E. , Gjertsen Bjørn Tore
Published: April 2023

PDF file - 314K, In vivo characterization of NTR/CytoCy5S fluorescence and fluorescence lifetime distributions in NB4NTR+GFP+ subcutaneous tumors, NCI-H460NTR+Luc+GFP+ orthotopic xenografts and gastrointestinal tract.
Supplementary Figure 2 from HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients
Authors: Munir Shamaila , Andersen Gitte Holmen , Met Özcan , Donia Marco , Frøsig Thomas Mørch , Larsen Stine Kiaer , Klausen Tobias Wirenfeldt , Svane Inge Marie , Andersen Mads Hald
Published: April 2023

PDF file - 36K, Blocking surface PD-1/PD-L1 did not effect the cytotoxic capacity of PD-1 negative, PD-L1 specific T cells
Supplementary Figure 1 from HLA-Restricted CTL That Are Specific for the Immune Checkpoint Ligand PD-L1 Occur with High Frequency in Cancer Patients
Authors: Munir Shamaila , Andersen Gitte Holmen , Met Özcan , Donia Marco , Frøsig Thomas Mørch , Larsen Stine Kiaer , Klausen Tobias Wirenfeldt , Svane Inge Marie , Andersen Mads Hald
Published: April 2023

PDF file - 39K, Correlation between PD-1 or PD-L1 expression and the presence of specific T-cell reactivity towards PD-L1
Supplementary Figures 1-6 from Chromosome Instability Modulated by BMI1–AURKA Signaling Drives Progression in Head and Neck Cancer
Authors: Chou Chun-Hung , Yang Neng-Kai , Liu Ting-Yun , Tai Shyh-Kuan , Hsu Dennis Shin-Shian , Chen Ya-Wei , Chen Yann-Jang , Chang Cheng-Chi , Tzeng Cheng-Hwai , Yang Muh-Hwa
Published: April 2023

PDF file -810KB, Twist1 upregulates Bmi1 and aurora kinase A expression, and co-amplification of BMI1 and AURKA in CD44+ HNSCC cells (S1); Akt pathway and let-7i repression are two independent mechanisms induced by Bmi1 to regulate aurora kinase A expression (S2); Suppression of Bmi1 or aurora kinase A reduces centrosomal amplification, aneuploidy, reduces p53 serine 315 phosphorylation and stabilizes p53 in OECM-1 cells (S3); Knockdown of aurora kinase A represses EMT, and overexpression of aurora kinase A is sufficient to induce EMT (S4); The influence of aurora kinase A on the expression of different EMT regulators (S5); Aurora kinase A increases GSK-3� phosphorylation and interacts with GSK-3� in HNSCC cell lines (S6)
Supplementary Figure Legend from Pirfenidone Inhibits Pancreatic Cancer Desmoplasia by Regulating Stellate Cells
Authors: Kozono Shingo , Ohuchida Kenoki , Eguchi Daiki , Ikenaga Naoki , Fujiwara Kenji , Cui Lin , Mizumoto Kazuhiro , Tanaka Masao
Published: April 2023

PDF file - 82K
Supplementary Table S1 from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Authors: Santo Evan E. , Stroeken Peter , Sluis Peter V. , Koster Jan , Versteeg Rogier , Westerhout Ellen M.
Published: April 2023

Supplementary Table S1 XLS file - 186K, Genes regulated in the SY5Y microarray experiments
Supplementary Methods from FOXO3a Is a Major Target of Inactivation by PI3K/AKT Signaling in Aggressive Neuroblastoma
Authors: Santo Evan E. , Stroeken Peter , Sluis Peter V. , Koster Jan , Versteeg Rogier , Westerhout Ellen M.
Published: April 2023

Supplementary Methods PDF file - 114K, Includes Lentiviral constructs, Western blotting & Cell fractionation, Luciferase constructs & reporter assay, Cell Viability Assay, Microarray profiling, and TFBS enrichment analysis. Also includes Supplementary References
Supplementary Figure Legend from Trask Loss Enhances Tumorigenic Growth by Liberating Integrin Signaling and Growth Factor Receptor Cross-Talk in Unanchored Cells
Authors: Spassov Danislav S. , Wong Ching Hang , Wong Sunny Y. , Reiter Jeremy F. , Moasser Mark M.
Published: April 2023

PDF file - 63K
Supplementary Figure Legends from Endocrine Fibroblast Growth Factor FGF19 Promotes Prostate Cancer Progression
Authors: Feng Shu , Dakhova Olga , Creighton Chad J. , Ittmann Michael
Published: April 2023

PDF file - 53KB
Supplementary Figure 1 from Endocrine Fibroblast Growth Factor FGF19 Promotes Prostate Cancer Progression
Authors: Feng Shu , Dakhova Olga , Creighton Chad J. , Ittmann Michael
Published: April 2023

PDF file - 684KB, Decreased viability of prostate cancer cells after FGF19 knockdown.
Supplementary Figures 1 - 6 from 3′-UTR Poly(T/U) Tract Deletions and Altered Expression of EWSR1 Are a Hallmark of Mismatch Repair–Deficient Cancers
Authors: Kishore Shivendra , Piscuoglio Salvatore , Kovac Michal B. , Gylling Annette , Wenzel Friedel , Trapani Francesca , Altermatt Hans Joerg , Mele Valentina , Marra Giancarlo , Peltomäki Päivi , Terracciano Luigi , Zavolan Mihaela , Heinimann Karl
Published: April 2023

PDF file - 300K, Supplementary Figure 1: Immunohistochemical profiling of DNA mismatch repair proteins in the extra-osseous Ewing Sarcoma. Supplementary Figure 2: Fluorescence in situ hybridization (FISH) analysis of the MHS6-related extra-osseous Ewing sarcoma. Supplementary Figure 3: Frequency distribution of EWS16T repeat alterations. Supplementary Figure 4: Schematic representation of EWSR1 3'UTR Supplementary Figure 5: Protein pull down assay representation. Supplementary Figure 6: Luciferase assay in different EWS16T tract variants.
Supplementary Table 3 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: April 2023

PDF file - 78K, Plasma pharmacokinetic parameters (Mean plus/minus SEM) of irinotecan bioactive metabolite SN-38 according to timing and chronotoxicity classes.
Supplementary Table 1 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: April 2023

PDF file - 86K, Irinotecan-induced changes in body weight according to sex and strain. Results from cosinor analysis with 24 + 12 h periodic components.
Supplementary Figure 3 from Redox Modulation of Adjacent Thiols in VLA-4 by AS101 Converts Myeloid Leukemia Cells from a Drug-Resistant to Drug-Sensitive State
Authors: Layani-Bazar Adi , Skornick Itai , Berrebi Alain , Pauker Maor H. , Noy Elad , Silberman Alon , Albeck Michael , Longo Dan L. , Kalechman Yona , Sredni Benjamin
Published: April 2023

PDF file - 718K, Fig. S3: The VLA-4 integrin activity on AML cells can be directly affected by AS101 by redox rearrangements of vicinal thiols within the cysteine-rich domain of the integrin resulting in physiologic consequences.
Supplementary Figure 2 from A Circadian Clock Transcription Model for the Personalization of Cancer Chronotherapy
Authors: Li Xiao-Mei , Mohammad-Djafari Ali , Dumitru Mircea , Dulong Sandrine , Filipski Elisabeth , Siffroi-Fernandez Sandrine , Mteyrek Ali , Scaglione Francesco , Guettier Catherine , Delaunay Franck , Lévi Francis
Published: April 2023

PDF file - 173K, Body weight loss as a function of irinotecan circadian timing in male or female mice from three mouse strains.
Supplementary Tables 1 - 3 from High-Throughput Tyrosine Kinase Activity Profiling Identifies FAK as a Candidate Therapeutic Target in Ewing Sarcoma
Authors: Crompton Brian D. , Carlton Anne L. , Thorner Aaron R. , Christie Amanda L. , Du Jinyan , Calicchio Monica L. , Rivera Miguel N. , Fleming Mark D. , Kohl Nancy E. , Kung Andrew L. , Stegmaier Kimberly
Published: April 2023

PDF file - 33K, Sequences for pLKO.1 FAK-targeting and CAS-targeting shRNAs (S1); Median fluorescent intensity for six Ewing sarcoma cell lines and 293FT cells measuring the phosphorylation level of 62 tyrosine kinases (S2); PF-562271 downregulates mTOR, AKT, and S6 phosphorylation (S3).
Supplementary Table 1 from Inhibition of Protein Kinase CK2 Reduces Cyp24a1 Expression and Enhances 1,25-Dihydroxyvitamin D3 Antitumor Activity in Human Prostate Cancer Cells
Authors: Luo Wei , Yu Wei-Dong , Ma Yingyu , Chernov Mikhail , Trump Donald L. , Johnson Candace S.
Published: April 2023

PDF file - 56K, Prostate tumor and matching normal
Supplementary Tables 1 - 4 from Targeting XRCC1 Deficiency in Breast Cancer for Personalized Therapy
Authors: Sultana Rebeka , Abdel-Fatah Tarek , Abbotts Rachel , Hawkes Claire , Albarakati Nada , Seedhouse Claire , Ball Graham , Chan Stephen , Rakha Emad A. , Ellis Ian O. , Madhusudan Srinivasan
Published: April 2023

PDF file - 104K, Supplemental Table S1: Clinicopathological characteristics of whole breast cancer cohort Supplemental Table S2: Clinicopathological characteristics of validation setSupplementary Table S3: Antigens, primary antibodies, clone, source, optimal dilution and scoring system used for each immunohistochemical marker Supplementary Table S4: siRNA constructs for XRCC1 knockdown
Supplementary Methods, Figures Legends 1-7 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: April 2023

PDF file - 129K
Supplementary Figure 4 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: April 2023

PDF file - 1MB, iNGR is cleaved upon entering the cells
Supplementary Figure 3 from De Novo Design of a Tumor-Penetrating Peptide
Authors: Alberici Luca , Roth Lise , Sugahara Kazuki N. , Agemy Lilach , Kotamraju Venkata R. , Teesalu Tambet , Bordignon Claudio , Traversari Catia , Rizzardi Gian-Paolo , Ruoslahti Erkki
Published: April 2023

PDF file - 517K, iNGR binding is not mediated by alphav integrins
Supplementary Table 1 from Genetic and Pharmacological Strategies to Refunctionalize the von Hippel Lindau R167Q Mutant Protein
Authors: Ding Zhiyong , German Peter , Bai Shanshan , Reddy A. Srinivas , Liu Xian-De , Sun Mianen , Zhou Lijun , Chen Xiaohua , Zhao Xiaobei , Wu Chengbiao , Zhang Shuxing , Mills Gordon B. , Jonasch Eric
Published: April 2023

XLSX file - 8KB, Missense Mutations of VHL in Renal Cell Carcinoma in the TCGA dataset.
Supplementary Figure 9 from Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK
Authors: Doma Eszter , Rupp Christian , Varga Andrea , Kern Florian , Riegler Bettina , Baccarini Manuela
Published: April 2023

PDF file - 98K, ERK‐dependent and -independent functions of Raf in Ras + Raf inhibitor‐induced tumorigenesis - a model.
Supplementary Figure 7 from Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK
Authors: Doma Eszter , Rupp Christian , Varga Andrea , Kern Florian , Riegler Bettina , Baccarini Manuela
Published: April 2023

PDF file - 74K, B‐ and C‐Raf are required for PLX‐4032, but not GDC‐0879‐induced ERK phosphorylation in primary wild‐type keratinocytes.
Supplementary Methods from Transcriptional Profiling of Melanoma Sentinel Nodes Identify Patients with Poor Outcome and Reveal an Association of CD30+ T Lymphocytes with Progression
Authors: Vallacchi Viviana , Vergani Elisabetta , Camisaschi Chiara , Deho Paola , Cabras Antonello D. , Sensi Marialuisa , De Cecco Loris , Bassani Niccolò , Ambrogi Federico , Carbone Antonino , Crippa Federica , Vergani Barbara , Frati Paola , Arienti Flavio , Patuzzo Roberto , Villa Antonello , Biganzoli Elia , Canevari Silvana , Santinami Mario , Castelli Chiara , Rivoltini Licia , Rodolfo Monica
Published: April 2023

PDF file - 93K
Supplementary Figure 4 from Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK
Authors: Doma Eszter , Rupp Christian , Varga Andrea , Kern Florian , Riegler Bettina , Baccarini Manuela
Published: April 2023

PDF file - 680K, B‐Raf or C‐Raf ablation prevents tumor development in PLX‐4032‐treated KS‐SOS‐F+ mice.
Supplementary Figure 2 from Skin Tumorigenesis Stimulated by Raf Inhibitors Relies Upon Raf Functions That Are Dependent and Independent of ERK
Authors: Doma Eszter , Rupp Christian , Varga Andrea , Kern Florian , Riegler Bettina , Baccarini Manuela
Published: April 2023

PDF file - 82K, Raf inhibitors activate ERK in human keratinocyte (HaCat) and squamous cell carcinoma (SCC) cell lines.
Supplementary Figure 3 from DNA Damage–Specific Control of Cell Death by Cryptochrome in p53-Mutant Ras–Transformed Cells
Authors: Lee Jin Hyup , Gaddameedhi Shobhan , Ozturk Nuri , Ye Rui , Sancar Aziz
Published: April 2023

PDF file - 165K, Downregulation of p73 eliminates enhanced UV-induced apoptosis caused by Cry mutation
Supplementary Figure 1 from DNA Damage–Specific Control of Cell Death by Cryptochrome in p53-Mutant Ras–Transformed Cells
Authors: Lee Jin Hyup , Gaddameedhi Shobhan , Ozturk Nuri , Ye Rui , Sancar Aziz
Published: April 2023

PDF file - 114K, Downregulation of Egr1 by pooled or single siRNA is specific and does not affect the E2F1 level and vise versa
Supplementary Tables 1 - 5, Figure 1 from Drug–Gene Modeling in Pediatric T-Cell Acute Lymphoblastic Leukemia Highlights Importance of 6-Mercaptopurine for Outcome
Authors: Beesley Alex H. , Firth Martin J. , Anderson Denise , Samuels Amy L. , Ford Jette , Kees Ursula R.
Published: April 2023

PDF file - 266K, Table S1 - Top 50 Correlating Probes For Each Drug Used in the 10 Drug Model. Table S2 - Drug-Gene Correlations for Genes Associated with Canonical Pathways of Multi-Drug Resistance, Detoxification and Metabolism (light shading p<0.01, dark shading with bold p<0.001). Table S3 -Details of Ingenuity Pathway Analysis for Individual Drugs, Drug Pairs, Genes of the 10 Drug Model, and the GC-MTX Reciprocity Index (data represent p-value and number of molecules (#) associated with significant sub-pathways). Table S4. Ten Drug Model Prediction Accuracies Across Different Cohorts Table S5 - Logistic Regression Models Used to Predict Patient Outcome in Each T-ALL Cohort. Figure S1 - Resistant Subgroups Within (A) POG-8704 and (B) POG-9404 Cohorts
Supplementary Figure 6 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Authors: Dey Joyoti , Dubuc Adrian M. , Pedro Kyle D. , Thirstrup Derek , Mecham Brig , Northcott Paul A. , Wu Xiaochong , Shih David , Tapscott Stephen J. , LeBlanc Michael , Taylor Michael D. , Olson James M.
Published: April 2023

PDF file - 2418K, MYOD is expressed across different molecular subgroups of medulloblastoma.
Supplementary Figure 4 from MyoD Is a Tumor Suppressor Gene in Medulloblastoma
Authors: Dey Joyoti , Dubuc Adrian M. , Pedro Kyle D. , Thirstrup Derek , Mecham Brig , Northcott Paul A. , Wu Xiaochong , Shih David , Tapscott Stephen J. , LeBlanc Michael , Taylor Michael D. , Olson James M.
Published: April 2023

PDF file - 12536K, MyoD expression is higher in the tumor periphery compared to the inner core.
Supplementary Figure 7 from Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer
Authors: LeBeau Aaron M. , Duriseti Sai , Murphy Stephanie T. , Pepin Francois , Hann Byron , Gray Joe W. , VanBrocklin Henry F. , Craik Charles S.
Published: April 2023

PDF file - 101K, Mouse model recreating the inflammation observed in Figure 4C. A nude mouse was injected subcutaneously with 100�l of turpentine oil. After 72hrs, the animal was injected with 258°Ci of FDG and imaged 60 minutes later. Probe uptake by the inflammatory cells is only observed with FDG and not with the uPAR probe
Supplementary Figure 6 from Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer
Authors: LeBeau Aaron M. , Duriseti Sai , Murphy Stephanie T. , Pepin Francois , Hann Byron , Gray Joe W. , VanBrocklin Henry F. , Craik Charles S.
Published: April 2023

PDF file - 58K, 177Lu-2G10 SPECT/CT imaging of a mouse enrolled in the RIT study. The mouse was injected with 2.5�g of 2G10 labeled with 75°Ci of 177Lu. The image shown is a coronal view acquitted at 24hrs post-injection. The represented data was processed using AMIDE software
Supplementary Figure 4 from Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer
Authors: LeBeau Aaron M. , Duriseti Sai , Murphy Stephanie T. , Pepin Francois , Hann Byron , Gray Joe W. , VanBrocklin Henry F. , Craik Charles S.
Published: April 2023

PDF file - 38K, Determining the half-life of the 111In-labeled antibodies in vivo (n = 3 mice / antibody)
Supplementary Figure 3 from Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer
Authors: LeBeau Aaron M. , Duriseti Sai , Murphy Stephanie T. , Pepin Francois , Hann Byron , Gray Joe W. , VanBrocklin Henry F. , Craik Charles S.
Published: April 2023

PDF file - 40K, Time activity curves for 111In-labeled 2G10 and 3C6 in MDA-MB-231 orthotopic xenograft tumor-bearing mice
Supplementary Figure 2 from Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer
Authors: LeBeau Aaron M. , Duriseti Sai , Murphy Stephanie T. , Pepin Francois , Hann Byron , Gray Joe W. , VanBrocklin Henry F. , Craik Charles S.
Published: April 2023

PDF file - 71K, Scrambled matched isotype control IgGs labeld with AlexaFlupr 680 at 72hrs in MDA-MB-231 xenografts imaged in the Cy 5.5 channel at 72hr
Supplementary Figure 1 from Targeting uPAR with Antagonistic Recombinant Human Antibodies in Aggressive Breast Cancer
Authors: LeBeau Aaron M. , Duriseti Sai , Murphy Stephanie T. , Pepin Francois , Hann Byron , Gray Joe W. , VanBrocklin Henry F. , Craik Charles S.
Published: April 2023

PDF file - 41K, The affinity of 2G10 and 3C6 Fabs and IgGs for MDA-MB-231 cells was determined by equilibrium binding flow cytometry. Isotherms were fit using non-linear regression methods to calculate KDs
Supplementary Figure 4 from Doxorubicin Eliminates Myeloid-Derived Suppressor Cells and Enhances the Efficacy of Adoptive T-Cell Transfer in Breast Cancer
Authors: Alizadeh Darya , Trad Malika , Hanke Neale T. , Larmonier Claire B. , Janikashvili Nona , Bonnotte Bernard , Katsanis Emmanuel , Larmonier Nicolas
Published: April 2023

PDF file - 87K, Doxorubicin is more efficient at selectively eliminating MDSC than cyclophosphamide, fludarabine, melphalan, vinblastine or etoposide.
Supplementary Figure 7 from Combined Anti-CD40 and Anti–IL-23 Monoclonal Antibody Therapy Effectively Suppresses Tumor Growth and Metastases
Authors: von Scheidt Bianca , Leung Patrick S.K. , Yong Michelle C.R. , Zhang Yu , Towne Jennifer E. , Smyth Mark J. , Teng Michele W.L.
Published: April 2023

PDF file - 77K, Intracellular staining of IL-23p19, IL-12p40 and TNF in GM-CSF derived BMDCs stimulated with various agonists.
Data Supplement from Optimal Effector Functions in Human Natural Killer Cells Rely upon Autocrine Bone Morphogenetic Protein Signaling
Authors: Robson Neil C. , Hidalgo Laura , McAlpine Tristan , Wei Heng , Martínez Víctor G. , Entrena Ana , Melen Gustavo J. , MacDonald Andrew S. , Phythian-Adams Alexander , Sacedón Rosa , Maraskovsky Eugene , Cebon Jonathan , Ramírez Manuel , Vicente Angeles , Varas Alberto
Published: April 2023

Supplemental Figure S5. Effects of DMH1 on NK cells IFN-y production and killing capacity upon target cell engagement.
Supplementary Table 1 from RSF1 Is a Positive Regulator of NF-κB–Induced Gene Expression Required for Ovarian Cancer Chemoresistance
Authors: Yang Yeong-In , Ahn Ji-Hye , Lee Kyung-Tae , Shih Ie-Ming , Choi Jung-Hye
Published: April 2023

PDF file - 122KB, Primer sequences for real-time PCR analysis.
Data Supplement from Neutralizing Murine TGFβR2 Promotes a Differentiated Tumor Cell Phenotype and Inhibits Pancreatic Cancer Metastasis
Authors: Ostapoff Katherine T. , Cenik Bercin Kutluk , Wang Miao , Ye Risheng , Xu Xiaohong , Nugent Desiree , Hagopian Moriah M. , Topalovski Mary , Rivera Lee B. , Carroll Kyla D. , Brekken Rolf A.
Published: April 2023

Supplemental Figures S1-S12. 2G8 does not bind to human TGFβR2 (S1); 2G8 treated stromal cells do not induce tumor cell proliferation (S2); 2G8 inhibits smad2 dependent signaling in a dose dependent fashion (S3); Tgfβr2 inhibition induces apoptosis and inhibits proliferation in a murine transgenic model of PDAC (S4); Tgfβr2 inhibition reduces perfusion and permeability in KIC tumors (S5); Collagen deposition and fibroblast infiltration is reduced after Tgfβr2 inhibition in PDAC (S6); 2G8 preserves M1 macrophage phenotype in the presence of exogenous TGF-β (S7); 2G8 promotes a proinflammatory immune cell phenotype in an immunocompetent model of PDAC (S8); 2G8 reduces metastatic burden in KIC mice (S9); 2G8 inhibition of tumor cell Tgfβr2 alone is insufficient to alter tumor cell epithelial/mesenchymal phenotype in vitro (S10); 2G8 inhibits EMT in multiple in vivo human xenograft models (S11); Cytokine changes in stromal cells in vitro after inhibition of Tgfβr2 (S12).
Supplementary Methods from Induction of Immunoregulatory CD271+ Cells by Metastatic Tumor Cells That Express Human Endogenous Retrovirus H
Authors: Kudo-Saito Chie , Yura Masahiro , Yamamoto Ryusuke , Kawakami Yutaka
Published: April 2023

PDF file - 94K
Supplementary Movie 2 from An Integrated Computational Model of the Bone Microenvironment in Bone-Metastatic Prostate Cancer
Authors: Araujo Arturo , Cook Leah M. , Lynch Conor C. , Basanta David
Published: April 2023

Prostate cancer bone microenvironment.
Supplementary Figures 1 - 7 from Myeloid-Derived Suppressor Cells as a Vehicle for Tumor-Specific Oncolytic Viral Therapy
Authors: Eisenstein Samuel , Coakley Brian A. , Briley-Saebo Karen , Ma Ge , Chen Hui-ming , Meseck Marcia , Ward Stephen , Divino Celia , Woo Savio , Chen Shu-Hsia , Pan Ping-Ying
Published: April 2023

PDF file - 653K, MDSC purity (S1); Effective Feridex labeling of MDSCs (S2); VSV does not alter the ability of MDSCs to migrate to tumor sites (S3); Antibody conjugation improves viral delivery to tumor sites (S4); VSV-MDSCs exhibit more tumor specificity than free virus (S5); VSV-MDSC treatment does not result in any appreciable neuropathological toxicity (S6); The survival curves of LLC lung cancer-bearing mice after various treatments (S7).
Supplementary Figures 1 - 2 from HAVCR/KIM-1 Activates the IL-6/STAT-3 Pathway in Clear Cell Renal Cell Carcinoma and Determines Tumor Progression and Patient Outcome
Authors: Cuadros Thaïs , Trilla Enric , Sarró Eduard , Vilà Maya R. , Vilardell Jordi , de Torres Inés , Salcedo Mayte , López-Hellin Joan , Sánchez Alex , Ramón y Cajal Santiago , Itarte Emilio , Morote Juan , Meseguer Anna
Published: April 2023

PDF file - 701K, Figure S1. RT-qPCR performed in independent clones confirmed that HAVCR/KIM-1 overexpressing 769-P cells exhibited increased mRNA IL-6 levels. Figure S2. As for 769-P cells, HAVCR/KIM-1 overexpression in 786-O cells (FUW-HAVCR) correlated with increased pSTAT-3 S727 levels when compared to 786-O control cells (FUW).
Supplementary Figure Legend from Myeloid-Derived Suppressor Cells as a Vehicle for Tumor-Specific Oncolytic Viral Therapy
Authors: Eisenstein Samuel , Coakley Brian A. , Briley-Saebo Karen , Ma Ge , Chen Hui-ming , Meseck Marcia , Ward Stephen , Divino Celia , Woo Savio , Chen Shu-Hsia , Pan Ping-Ying
Published: April 2023

PDF file - 26K
Supplementary Materials and Methods, Figure Legends, Figures 1 - 7, Tables 1 - 4 from Novel Strategies to Enforce an Epithelial Phenotype in Mesenchymal Cells
Authors: Dragoi Ana-Maria , Swiss Rachel , Gao Beile , Agaisse Hervé
Published: April 2023

PDF file - 2248KB, Supplementary Materials and Methods section provides detailed experimental procedures for antibiotic protection assay, bacterial infection, RNAi screen, quantitative PCR, high-throughput imaging and computer-assisted image analysis, antibodies, DNA constructs, gene expression profile analysis of microarray data and immuno- precipitation, immunoblotting and biotinylation assay. Supplementary Figures 1-7 illustrate L. monocytogenes invasion of epithelial cells depends on Ecadherin expression (S1), transcriptional and post-transcriptional regulators of E-cadherin expression (S2), E- cadherin mRNA and protein expression levels in cells depleted for the identified candidate factors (S3), methods for quantification of soft- agar colony formation (S4), images corresponding to the FLASH siRNA genetic rescue experiments (S5), properties of miR-mimics ZNF281_D1 and PON3_D2 (S6) and regulation of epithelial and mesenchymal markers in miR-mimic duplexes-treated cells. Supplementary Table 1-4 illustrate the complete validation of the candidate genes identified in the RNAi screen (S1), the validation of the E-cadherin regulators in MDA-MB 231 cells (S2), the list of genes displaying ZEB-1-dependent (S3) and FLASH-dependent expression (S4).
Supplementary Methods from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis
Authors: Huang Wei-Chieh , Chan Shih-Hsuan , Jang Te-Hsuan , Chang Jer-Wei , Ko Ying-Chin , Yen Tzu-Chen , Chiang Shang-Lun , Chiang Wei-Fan , Shieh Tien-Yu , Liao Chun-Ta , Juang Jyh-Lyh , Wang Hsueh-Chun , Cheng Ann-Joy , Lu Ya-Ching , Wang Lu-Hai
Published: April 2023

PDF file - 108K
Supplementary Figures 1 - 11 from miRNA-491-5p and GIT1 Serve as Modulators and Biomarkers for Oral Squamous Cell Carcinoma Invasion and Metastasis
Authors: Huang Wei-Chieh , Chan Shih-Hsuan , Jang Te-Hsuan , Chang Jer-Wei , Ko Ying-Chin , Yen Tzu-Chen , Chiang Shang-Lun , Chiang Wei-Fan , Shieh Tien-Yu , Liao Chun-Ta , Juang Jyh-Lyh , Wang Hsueh-Chun , Cheng Ann-Joy , Lu Ya-Ching , Wang Lu-Hai
Published: April 2023

PDF file - 856K, Selection of highly invasive oral cancer cells (S1); Overexpressing miR-491-5p inhibited lung metastasis in SCID mice (S2); The GIT1 mRNA level is upregulated in highly invasive OSCC lines (S3); GIT1 was overexpressed in the highly invasive oral cancer lines (S4); Knockdown of GIT1 by siRNA-3 had no affect paxillin mRNA expression (S5); DN-FAK suppresses GIT1-induced cell migration and invasion in OSCC cells (S6); Effect of ERK1/2 on MMP2/9 mRNA expression in OSCC cells (S7); Overexpression of miR-491-5p did not decrease proliferation in OSCC cells before 72h time point (S8); Effect of the DN-MEK or PD98059 on GIT1 induced MMP2/9 mRNA expression in OSCC cells (S9); Depletion of FAK and GIT1 decreased the paxillin and FAK phosphorylation (S10); CGHNC9 cells were transfected with FAM-labeled miR-491-5p (S11).
Supplementary Movie 5 from Curcumin Targets Breast Cancer Stem–like Cells with Microtentacles That Persist in Mammospheres and Promote Reattachment
Authors: Charpentier Monica S. , Whipple Rebecca A. , Vitolo Michele I. , Boggs Amanda E. , Slovic Jana , Thompson Keyata N. , Bhandary Lekhana , Martin Stuart S.
Published: April 2023

MOV file - 1194K, Live cell confocal imaging of BT-549 mammosphere stained with CellMask Orange (red) and transduced with GFP-membrane (green) suspended over a glass surface. Cross-sections reveal McTNs from the GFP-membrane cell encircling other cells in the mammosphere.
Supplementary Figure 5 from Compensatory Functions and Interdependency of the DNA-Binding Domain of BRCA2 with the BRCA1–PALB2–BRCA2 Complex
Authors: Al Abo Muthana , Dejsuphong Donniphat , Hirota Kouji , Yonetani Yasukazu , Yamazoe Mitsuyoshi , Kurumizaka Hitoshi , Takeda Shunichi
Published: April 2023

PDF file - 24K, Quantification of RAD51 foci in individual cells of the indicated genotype.