bluuebunny/crossref_metadata_2025 huggingface dataset:
Experimental Study on the Reaction of Magnesium in Carbon Dioxide and Nitrogen Atmosphere
Authors: Barabulica Ioan , Secula Marius Sebastian , Asoltanei Adriana Mariana , Iacob-Tudose Eugenia Teodora , Lisa Gabriela , Mamaliga Ioan
Published: April 2024

This manuscript presents an experimental study focusing on the combustion of magnesium in an atmosphere depleted of oxygen. The study explores various mixtures of carbon dioxide and nitrogen, examining their impact on the combustion performance. The experimental design involved evaluating how the carbon content influences combustion parameters. Temperature profiles were analyzed to elucidate different stages of the combustion process. Furthermore, the effects of pressure (2 and 3 ata) and the composition of CO2-N2 mixtures (10%, 19.5%, 35%, 48%, 72%, and 80% CO2 content) on magnesium combustion, including ignition time, maximum temperature, and post-combustion temperatures, were investigated. The results revealed a substantial impact on the ignition delay and combustion time, with the ignition delay decreasing with higher chamber pressure. The combustion process, especially with regard to the ignition time and heat of combustion, was notably affected by CO2 concentration. The morphology of the combustion residue from the magnesium microparticles was characterized using scanning electron microscopy combined with energy-dispersive X-ray spectroscopy (SEM-EDX). The reaction of Mg with CO2 represents a promising energy source, quickly releasing a substantial amount of heat with a very low quantity of Mg. The estimated value of the heat of combustion for magnesium in N2-CO2 atmosphere is 78.4 kJ mol−1.
Application of Sensing Devices in the Detection of Oral, Pulmonary, and Gastrointestinal Diseases
Authors: Yu Weijie , Mou Shimeng , Zhang Xiaojing , Sun Jiaying , Xue Yingying , Xiong Hangming , Hsia K. Jimmy , Wan Hao , Wang Ping
Published: April 2024

Biomedical sensing technology is developing at a tremendous pace and is expected to become an effective clinical tool for the diagnosis and monitoring of human health. The development of sensing devices has successfully transformed the specific sensor prototype designed in the laboratory into a commercially feasible clinical disease detection device. Recently, sensing devices have been accelerated and extended to various fields beyond disease detection, including the measurement of gastrointestinal physiological parameters such as pH, VOC detection, small-molecule gas sensing, and noninvasive screening of oral and lung diseases such as oral cancer, gastric cancer, and other major diseases. In this review, the applications of sensors and electronic nose devices in the diagnosis and monitoring of oral, pulmonary, and gastrointestinal diseases are reviewed, as well as the design and application of sensor materials in disease markers and in situ detection. This article also introduces the practical application of sensing devices in human disease detection, critically analyzes their detection mechanisms and clinical utility, and discusses their future development in medicine. We believe that this review will help readers, especially practitioners in the medical field, provide ideas for the development of sensing devices.
Family Resilience and Children’s Subjective Well-Being: A Two-Wave Study
Authors: Brajša-Žganec Andreja , Džida Marija , Kućar Maja
Published: April 2024

According to the Theory of Change, the resilience of the family unit plays a crucial role in shaping the developmental trajectory of children. Families exhibiting higher levels of family resilience are typically characterized by transparent and effective communication, optimistic outlooks on adversity, adept problem-solving skills, strong spiritual beliefs, and effective management of social and financial resources. While existing research has indicated that parental and familial characteristics can predict diverse outcomes for children, investigations concerning the association between family resilience and children’s subjective well-being remains limited. Therefore, this study aims to examine whether different dimensions of family resilience can predict changes in children’s subjective well-being, tested one year later. The sample includes 762 child-mother-father triads (intact families). Children aged 9–13 years (48% boys, age = 11.04, SD = 1.16) assessed their life satisfaction, positive and negative affect in two study waves, while mothers and fathers assessed family resilience in the first wave. A dyadic data common fate model was employed to create latent variables representing family resilience. Three latent variables were: family problem-solving, family spirituality, and utilization of social and economic resources. Findings from the structural equation model indicated a positive association between higher levels of family problem-solving and increased children’s life satisfaction, alongside a negative relationship between higher family spirituality and negative affect. Parental assessments of social and economic resources utilization were not uniquely related to children’s life satisfaction, positive, or negative affect.
Prevalence of Infectious Diseases in Children at Preschool Education Institutions and Stakeholder Opinions
Authors: Kurt Gonca , Serdaroğlu Hasan Uğur
Published: April 2024

Preschool education institutions, where children have close contact and social interactions, can serve as potential environments for the transmission of infectious diseases. This issue poses a significant health concern, impacting both individual and public well-being. Thus, the present research set out to determine the prevalence of infectious diseases in preschool children and the views of parents and teachers on the prevention of infectious diseases. The study employed a mixed-method approach and involved 397 parents and 46 preschool teachers. The study was survey-based via in-person interviews. The results revealed that after they started school (almost in 5 months), children with a mean age of 4.7 ± 0.5 years experienced illness approximately 3.5 ± 2.0 times, of whom 91.5% used antibiotics. The prevalence of infectious diseases was found to be associated with the child’s being born at term, maternal education level, and the public/private status of preschool institutions. The presence of a sick child in the classroom elicits negative emotions from both teachers and parents. They recommend that studies on education, safety, hygiene, school health, health screenings, regulation of the learning environment, legal regulations, and school exclusion policies be carried out to prevent infectious diseases. When children with infectious diseases come to school, nearly half of the teachers admit them to the classroom due to various reasons and pressures. Parents request teachers to monitor medication, control sweating, and use a nebulizer for their sick children. Some of the teachers meet these requests, but they claim that the educational process is negatively affected. At preschool education institutions, the risk factors of infectious diseases have a complex structure and can be influenced by variables related to teachers, children, parents and the institution itself. Infectious diseases not only pose a threat to health but also impact teachers’ and parents’ emotions, teacher–child relationships, and the overall atmosphere within schools and classrooms.
Severe Crowding Associated with Lower Canine Premature Resorption: Interceptive Treatment with Clear Aligners—A Pilot Study
Authors: Gazzani Francesca , Pavoni Chiara , Loberto Saveria , Caruso Silvia , Cozza Paola
Published: April 2024

Background: Early mixed dentition represents a critical phase since crowding conditions can occur. The interceptive resolution of dental crowding allows favorable arch and occlusal development. The aim of the present investigation was to evaluate dentoalveolar changes of clear aligner treatment planned to manage lower incisor crowding, loss of arch length, and midline deviation in early mixed dentition. Methods: A total of 13 patients (7 females, 6 males, 9.4 ± 1.2 age) treated with clear aligners were selected. Arch dimensions and incisor inclinations were evaluated before (T0) and at the end of interceptive treatment (T1). A paired t-test was chosen to compare T1–T0 changes. The level of significance was set at 5%. Results: The greatest significant increase in mandibular width was observed at the level of the first deciduous molars (+2.44 ± 1.4 mm), followed by the second permanent molars (+2.16 ± 1.4 mm). Lower arch length and arch depth showed a statistically relevant increase (2 ± 0.6 mm and 4.5 ± 1.6 mm, respectively). The mean lower dental midline changes were statistically significant (1.42 ± 0.73 mm). Conclusions: Early treatment with clear aligners, including the combination of transversal arch development, maintenance of leeway space, and guidance of eruption, represents a valid treatment strategy in early mixed dentition to manage arch crowding and occlusion development.
Performance Rating and Flow Analysis of an Experimental Airborne Drag-Type VAWT Employing Rotating Mesh
Authors: Güneş Doğan , Kükrer Ergin
Published: April 2024

This paper presents the results of a performance analysis conducted on an experimental airborne vertical axis wind turbine (VAWT), specifically focusing on the MAGENN Air Rotor System (MARS) project. During its development phase, the company claimed that MARS could generate a power output of 100 kW under wind velocities of 12 m/s. However, no further information or numerical models supporting this claim were found in the literature. Extending our prior conference work, the main objective of our study is to assess the accuracy of the stated rated power output and to develop a comprehensive numerical model to analyze the airflow dynamics around this unique airborne rotor configuration. The innovative design of the solid model, resembling yacht sails, was developed using images in the related web pages and literature, announcing the power coefficient (Cp) as 0.21. In this study, results cover 12 m/s wind and flat terrain wind velocities (3, 5, 6, and 9 m/s) with varying rotational velocities. Through meticulous calculations for the atypical blade design, optimal rotational velocities and an expected Tip Speed Ratio (TSR) of around 1.0 were determined. Introducing the Centroid Speed Ratio (CSR), which is the ratio of the sail blade centroid and the superficial wind velocities for varied wind speeds, the findings indicate an average power generation potential of 90 kW at 1.4 rad/s for 12 m/s and approximately 16 kW at a 300 m altitude for a 6 m/s wind velocity.
Learning from conect4children: A Collaborative Approach towards Standardisation of Disease-Specific Paediatric Research Data
Authors: Sen Anando , Hedley Victoria , Degraeuwe Eva , Hirschfeld Steven , Cornet Ronald , Walls Ramona , Owen John , Robinson Peter N. , Neilan Edward G. , Liener Thomas , Nisato Giovanni , Modi Neena , Woodworth Simon , Palmeri Avril , Gaentzsch Ricarda , Walsh Melissa , Berkery Teresa , Lee Joanne , Persijn Laura , Baker Kasey , An Haack Kristina , Segovia Simon Sonia , Jacobsen Julius O. B. , Reggiardo Giorgio , Kirwin Melissa A. , Trueman Jessie , Pansieri Claudia , Bonifazi Donato , Nally Sinéad , Bonifazi Fedele , Leary Rebecca , Straub Volker
Published: April 2024

The conect4children (c4c) initiative was established to facilitate the development of new drugs and other therapies for paediatric patients. It is widely recognised that there are not enough medicines tested for all relevant ages of the paediatric population. To overcome this, it is imperative that clinical data from different sources are interoperable and can be pooled for larger post hoc studies. c4c has collaborated with the Clinical Data Interchange Standards Consortium (CDISC) to develop cross-cutting data resources that build on existing CDISC standards in an effort to standardise paediatric data. The natural next step was an extension to disease-specific data items. c4c brought together several existing initiatives and resources relevant to disease-specific data and analysed their use for standardising disease-specific data in clinical trials. Several case studies that combined disease-specific data from multiple trials have demonstrated the need for disease-specific data standardisation. We identified three relevant initiatives. These include European Reference Networks, European Joint Programme on Rare Diseases, and Pistoia Alliance. Other resources reviewed were National Cancer Institute Enterprise Vocabulary Services, CDISC standards, pharmaceutical company-specific data dictionaries, Human Phenotype Ontology, Phenopackets, Unified Registry for Inherited Metabolic Disorders, Orphacodes, Rare Disease Cures Accelerator-Data and Analytics Platform (RDCA-DAP), and Observational Medical Outcomes Partnership. The collaborative partners associated with these resources were also reviewed briefly. A plan of action focussed on collaboration was generated for standardising disease-specific paediatric clinical trial data. A paediatric data standards multistakeholder and multi-project user group was established to guide the remaining actions—FAIRification of metadata, a Phenopackets pilot with RDCA-DAP, applying Orphacodes to case report forms of clinical trials, introducing CDISC standards into European Reference Networks, testing of the CDISC Pediatric User Guide using data from the mentioned resources and organisation of further workshops and educational materials.
The Impact of COVID-19 on Amputation and Mortality Rates in Patients with Acute Limb Ischemia: A Systematic Review and Meta-Analysis
Authors: Crupi Lelio , Ardizzone Alessio , Calapai Fabrizio , Scuderi Sarah Adriana , Benedetto Filippo , Esposito Emanuela , Capra Anna Paola
Published: April 2024

Since the inception of the SARS-CoV-2 pandemic, healthcare systems around the world observed an increased rate of Acute Limb Ischemia (ALI) in patients with a COVID-19 infection. Despite several pieces of evidence suggesting that COVID-19 infection may also worsen the prognosis associated with ALI, only a small number of published studies include a direct comparison regarding the outcomes of both COVID-19 and non-COVID-19 ALI patients. Based on the above, a systematic review and a meta-analysis of the literature were conducted, evaluating differences in the incidence of two major outcomes (amputation and mortality rate) between patients concurrently affected by COVID-19 and negative ALI subjects. PubMed (MEDLINE), Web of Science, and Embase (OVID) databases were scrutinized from January 2020 up to 31 December 2023, and 7906 total articles were recovered. In total, 11 studies (n: 15,803 subjects) were included in the systematic review, and 10 of them (15,305 patients) were also included in the meta-analysis. Across all the studies, COVID-19-positive ALI patients experienced worse outcomes (mortality rates ranging from 6.7% to 47.2%; amputation rates ranging from 7.0% to 39.1%) compared to non-infected ALI patients (mortality rates ranging from 3.1% to 16.7%; amputation rates ranging from 2.7% to 18%). Similarly, our meta-analysis shows that both the amputation rate (OR: 2.31; 95% CI: 1.68–3.17; p < 0.00001) and mortality (OR: 3.64; 95% CI: 3.02–4.39; p < 0.00001) is significantly higher in COVID-19 ALI patients compared to ALI patients.
Establishment and Verification of the UAV Coupled Rotor Airflow Backward Tilt Angle Controller
Authors: Wu Han , Liu Dong , Zhao Yinwei , Liu Zongru , Liang Yunting , Liu Zhijie , Huang Taoran , Liang Ke , Xie Shaoqiang , Li Jiyu
Published: April 2024

At present, all the flight controllers of agricultural UAVs cannot accurately and quickly control the influencing factors of the UAV coupled rotor airflow backward tilt angle during the application process. To solve the above problem, a Rotor Airflow Backward Tilt Angle (RABTA) controller is established in this paper. The RABTA controller integrates advanced sensor technology with a novel algorithmic approach, utilizing real-time data acquisition and state–space analysis to dynamically adjust the UAV’s rotor airflow, ensuring precise control of the backward tilt angle. The control effect of the traditional flight controller and RABTA controller in the process of pesticide application and the corresponding operation effect are compared and analyzed. The comparison results show that the RABTA controller reduces the control error to less than 1 degree, achieving a 48.3% improvement in the uniformity of the distribution of pesticides droplets across the crop canopy, which means that the UAV field application effect is implemented and the innovation of the UAV field application control mode is realized.
A Multifunctional Approach to Optimizing Woven Fabrics for Thermal Protective Clothing
Authors: Schwarz Ivana , Rogale Dubravko , Kovačević Stana , Firšt Rogale Snježana
Published: April 2024

This paper presents a detailed exploration of the development and characterization of multifunctional dual-purpose woven fabrics for thermal protective clothing. Through this research, 69 woven fabric prototypes have been carefully designed and produced, integrating various raw materials, yarn, and woven fabric construction parameters, with the aim of optimizing thermal protection properties while ensuring comfort and durability. The analysis led to the identification of two optimal woven fabric samples, which, upon further testing, exhibited exceptional dimensional stability, crease recovery, tear resistance, as well as abrasion and water resistance. Furthermore, the thermal properties were evaluated, demonstrating exceptional flame resistance, limited heat transmission, and high thermal insulation. Additionally, the study evaluated dynamic thermal properties, contact conductive heat transfer, air permeability, water vapour resistance, and thermal resistance of two clothing systems constructed from selected woven fabrics. Statistical analysis confirms significant differences between clothing systems, highlighting the influence of yarn composition and fabric structure on thermal performance and comfort, where one system exhibits better thermal insulation characteristics suitable for colder environments while the other excels in breathability for warmer climates. The developed woven fabrics meet high standards for protective clothing against heat and flame, surpassing currently available comparable woven fabrics on the market in terms of efficacy and performance. This research provides insights into the intricate balance between protection, comfort, and durability of woven fabrics, contributing to advancements in protective textile technology.
A Fireline Displacement Model to Predict Fire Spread
Authors: Viegas Domingos X. , Ribeiro Carlos , Barbosa Thiago Fernandes , Rodrigues Tiago , Ribeiro Luís M.
Published: April 2024

Most current surface fire simulators rely upon Rothermel’s model, which considers the local properties of fuel, topography, and meteorology to estimate the rate of spread, and utilises the concept of elliptical growth to predict the evolution of the fire perimeter throughout time. However, the effects of convective processes near the fireline, which modify fire spread conditions along the fire perimeter, are not considered in this model. An innovative fire prediction simulator based on the concept of fireline element displacement, which is composed of translation, rotation, and extension, rather than a point-by-point displacement, is proposed in this article. Based on the laws of convective heat fluxes across and along the fireline and on laboratory experiments, models to estimate the angular rotation velocity and the extension of the fireline during its displacement are proposed. These models are applied to a set of laboratory experiments of point ignition fires on slopes of 30° and 40° and, given the fact that the rate of spread of the head, back, and flank fire are known, the evolution of the fire perimeter can be predicted. The fire spread model can be applied to other situations of varying boundary conditions provided that the parameters required by the model are known.
Experimental and Theoretical Investigation of Longitudinal Temperature Attenuation and Smoke Movement in Urban Utility Tunnel Fires
Authors: Cao Biteng , Liu Hong , Fan Rui , Ju Xiaoyu , Yang Lizhong
Published: April 2024

The urban utility tunnel is an indispensable part of modern engineering construction. However, the fire risk cannot be ignored due to the narrow space and limited ventilation of the utility tunnel. A study of smoke filling is performed in a 1/8-scaled utility tunnel (25 m × 0.5 m × 0.45 m). Five heat release rates (5, 10, 15, 20 and 25 kW) and four positions of fire sources are used for tests. The initial position of the one-dimensional smoke movement of strong plume is determined. Based on the traditional model, the longitudinal temperature attenuation model of tunnel smoke is established with consideration of radiation and convection heat losses. The theoretical value of the longitudinal temperature rise of smoke is in good agreement with the experimental value. A one-dimensional spreading velocity model is established that coincides well with the experimental value, and the relative error is less than 20%. The spreading velocity of smoke is increased by the heat release rate. The velocity of the smoke spreading at the near end is smaller than that at the center, due to the long spreading route. The current conclusions disclosed in this study provide important guidance for the ventilation design of utility tunnels for fire smoke scenarios.
Clovamide and Its Derivatives—Bioactive Components of Theobroma cacao and Other Plants in the Context of Human Health
Authors: Kolodziejczyk-Czepas Joanna
Published: April 2024

Clovamide (N-caffeoyl-L-3,4-dihydroxyphenylalanine, N-caffeoyldopamine, N-caffeoyl-L-DOPA) is a derivative of caffeic acid, belonging to phenolamides (hydroxycinnamic acid amides). Despite a growing interest in the biological activity of natural polyphenolic substances, studies on the properties of clovamide and related compounds, their significance as bioactive components of the diet, as well as their effects on human health are a relatively new research trend. On the other hand, in vitro and in vivo evidence indicates the considerable potential of these substances in the context of maintaining human health or using them as pharmacophores. The name “clovamide” directly derives from red clover (Trifolium pratense L.), being the first identified source of this compound. In the human diet, clovamides are mainly present in chocolate and other cocoa-containing products. Furthermore, their occurrence in some medicinal plants has also been confirmed. The literature reports deal with the antioxidant, anti-inflammatory, neuroprotective, antiplatelet/antithrombotic and anticancer properties of clovamide-type compounds. This narrative review summarizes the available data on the biological activity of clovamides and their potential health-supporting properties, including prospects for the use of these compounds for therapeutic purposes.
Climate Change Impacts on Potato Storage
Authors: Zhang Shu , Wang Xiuquan , Kinay Pelin , Dau Quan
Published: April 2024

In this study, we present a comprehensive literature review of the potential impacts of climate change on potato storage. Potato preservation can help reduce food loss and waste while increasing long-term food security, as potatoes are one of the most important crops worldwide. The review’s results suggest climate change can negatively affect potato storage, especially tuber sprouting and diseases in storage chambers. Lower Sielianinov coefficient values (indicating dry and hot conditions) during the vegetative season of potato growing can lead to earlier sprouting. For instance, a decrease of 0.05 in the Sielianinov coefficient during the growing season results in tubers stored at 3 °C sprouting 25 days earlier and tubers stored at 5 °C experiencing a 15-day reduction in dormancy. This is due to the fact that the dry and hot climate conditions during the vegetation period of potato planting tend to shorten potato tubers’ natural dormancy, which further leads to earlier sprouting during storage. Furthermore, high Sielianinov coefficient values may lead to worse disease situations. The results also suggest that research about the impacts of climate change on potato storage is very limited at the current stage, and further studies are needed to address the key knowledge gaps identified in this study.
The Protective Effects of L-Theanine against Epigallocatechin Gallate-Induced Acute Liver Injury in Mice
Authors: Zhu Kun , Zeng Hongzhe , Yue Lin , Huang Jianan , Ouyang Jie , Liu Zhonghua
Published: April 2024

Epigallocatechin-3-gallate (EGCG) is a main bioactive constituent in green tea. Being a redox-active polyphenol, high-dose EGCG exhibits pro-oxidative activity and could cause liver injury. L-theanine is a unique non-protein amino acid in green tea and could provide liver-protective effects. The purpose of this study was to investigate the hepatoprotective effects of L-theanine on EGCG-induced liver injury and the underlying mechanisms. A total of 300 mg/kg L-theanine was administrated to ICR mice for 7 days. Then, the acute liver injury model was established through intragastric administration of 1000 mg/kg EGCG. Pretreatment with L-theanine significantly alleviated the oxidative stress and inflammatory response caused by high-dose EGCG through modulation of Nrf2 signaling and glutathione homeostasis. Furthermore, metabolomic results revealed that L-theanine protects mice from EGCG-induced liver injury mainly through the regulation of amino acid metabolism, especially tryptophan metabolism. These findings could provide valuable insights into the potential therapeutic applications of L-theanine and highlight the importance of the interactions between dietary components.
Physico-Chemical and Rheological Trait-Based Identification of Indian Wheat Varieties Suitable for Different End-Uses
Authors: Singh Sumit Kumar , Singhal Shaily , Jaiswal Praful , Basu Umer , Sahi Anant Narayan , Singh Anju Mahendru
Published: April 2024

India has increased its wheat production phenomenally in the last two decades and it now has a buffer stock of 9.7 million tonnes. However, despite the release of several wheat cultivars, the end-use quality traits of Indian wheat varieties have not been explored in-depth to determine the increasing demand of the domestic processing industry as well as export. In this study, 55 wheat genotypes including 47 released varieties, and 8 genetic stocks were grown along with 10 Australian varieties grown during cropping seasons: 2019–2020 and 2020–2021 and diversity in different physiochemical and rheological traits was evaluated. They showed considerable diversity in all the quality traits studied. However, very few genotypes could be found suitable for any one end-use. Five genotypes were found to possess four to five traits for superior bread-making quality. Two varieties and three advanced breeding lines had up to four good chapati quality traits. None of the released varieties investigated had suitable traits for biscuit making; however, two breeding lines possessed requisite quality traits suitable for biscuit making. It is, therefore, concluded that systematic breeding efforts are required to develop genotypes that bring together the most important quality traits in a single genotype to be suitable for domestic industry as well as for export.
Grain Products: Traditional and Innovative Technologies
Authors: Gómez Manuel , Pereira Eliana
Published: April 2024

The current knowledge regarding various cereals, their composition, and their processing methods is extensive [...]
Discrimination between the Triglyceride Form and the Ethyl Ester Form of Fish Oil Using Chromatography–Mass Spectrometry
Authors: Liu Mingxuan , Liu Yuchong , Wang Xiupin
Published: April 2024

Although the triglyceride form is the natural form of fish oil found in fish, the ethyl ester form of fish oil, which is used during processing to save costs, is also present on the market. In this study, fatty acids and lipids were determined using gas chromatography–mass spectrometry (GC–MS) and liquid chromatography–linear ion trap mass spectrometry (LC–LIT/MS), respectively, according to developed methods. The identification of fatty acids was based on the mass spectral characteristics and equivalent chain lengths. However, the fatty acid contents of both forms of fish oils are quite similar. The application of the LC–LIT/MS method for the structural characterization of triacylglycerols (TAGs) and the mechanism of LIT/MS fragmentation are also discussed. Neutral losses of CH2=CH2 (m/z 28) and CH3CH2OH (m/z 46), which are LIT/MS characteristics of ethyl ester from fish oil, were found for the first time. The triglyceride form of fish oils was easily and accurately identified using fingerprint chromatography. In conclusion, lipid analysis combined with LC–LIT/MS showed an improved capability to distinguish between types of fish oil.
A Note on Averaging Principles for Fractional Stochastic Differential Equations
Authors: Liu Jiankang , Zhang Haodian , Wang Jinbin , Jin Chen , Li Jing , Xu Wei
Published: April 2024

Over the past few years, many scholars began to study averaging principles for fractional stochastic differential equations since they can provide an approximate analytical method to reduce such systems. However, in the most previous studies, there is a misunderstanding of the standard form of fractional stochastic differential equations, which consequently causes the wrong estimation of the convergence rate. In this note, we take fractional stochastic differential equations with Lévy noise as an example to clarify these two issues. The corrections herein have no effect on the main proofs except the two points mentioned above. The innovation of this paper lies in three aspects: (i) the standard form of the fractional stochastic differential equations is derived under natural time scale; (ii) it is first proved that the convergence interval and rate are related to the fractional order; and (iii) the presented results contain and improve some well known research achievements.
Effect of Starch Types on the Textural and Rehydration Properties of Extruded Peanut Protein Pore Gel Particles
Authors: Guo Feng , Hu Anna , Zhou Huan , Hu Hui , Li Tongqing , Wang Qiang , Zhang Jinchuang
Published: April 2024

In this study, the effect of different starches from corn, potato and pea containing varying amylose/amylopectin ratios on the textural and rehydration properties of extruded peanut protein gel particles were investigated. Results showed that textural and rehydration properties of peanut protein extruded with corn starch, potato starch and amylopectin are slightly inferior to those of peanut protein with pea starch extrudates. The addition of pea starch led to an increase in the pore structure of the peanut protein extrudates and improved their water absorption index, simultaneously reducing the hardness and density. Pea starch, as a natural water-absorbing expansion material, helped peanut protein to form cross-linked gel polymers that bind more water molecules, in addition to further polymerization with peanut protein, which made the protein secondary structure became disordered. These changes directly affected the textural properties of the extrudates. In addition, the blended system of starches and peanut protein tended to form more elastic solids, which affected the expansion of the extrudates. These findings indicate that starch can effectively improve the poor expansion of proteins, making it suitable for use in the production of plant protein-based foods.
A Unifying Hypothesis for the Genome Dynamics Proposed to Underlie Neuropsychiatric Phenotypes
Authors: Gericke George Sebastian
Published: April 2024

The sheer number of gene variants and the extent of the observed clinical and molecular heterogeneity recorded in neuropsychiatric disorders (NPDs) could be due to the magnified downstream effects initiated by a smaller group of genomic higher-order alterations in response to endogenous or environmental stress. Chromosomal common fragile sites (CFS) are functionally linked with microRNAs, gene copy number variants (CNVs), sub-microscopic deletions and duplications of DNA, rare single-nucleotide variants (SNVs/SNPs), and small insertions/deletions (indels), as well as chromosomal translocations, gene duplications, altered methylation, microRNA and L1 transposon activity, and 3-D chromosomal topology characteristics. These genomic structural features have been linked with various NPDs in mostly isolated reports and have usually only been viewed as areas harboring potential candidate genes of interest. The suggestion to use a higher level entry point (the ‘fragilome’ and associated features) activated by a central mechanism (‘stress’) for studying NPD genetics has the potential to unify the existing vast number of different observations in this field. This approach may explain the continuum of gene findings distributed between affected and unaffected individuals, the clustering of NPD phenotypes and overlapping comorbidities, the extensive clinical and molecular heterogeneity, and the association with certain other medical disorders.
Dorsal Practices—Towards a Back-Oriented Being-in-the-World
Authors: Brown Katrina , Cocker Emma
Published: April 2024

Dorsal Practices is a process-based, interdisciplinary artistic collaboration between choreographer Katrina Brown and writer–artist Emma Cocker. This research enquiry explores the notion of dorsality and the cultivation of a back-oriented awareness in relation to how we as sentient bodies orientate to the self, others (human, more-than-human), and interconnected world. Since 2021, Dorsal Practices has unfolded through the interrelation of three fields of experimental, embodied research practice: movement-based practices, conversation practices, and experimental reading practices. Dorsal Practices explores how the tilt or inclination towards dorsal (dis)orientation might enable new modes of thinking–perceiving and being–with, and more connected, sustainable ways of living and aliveness based on the reciprocal, entangled relationship between self/environment. We ask: How does the cultivation of a back-oriented awareness and attitude shape and inform our embodied, affective, and relational experience of being-in-the-world? Rather than a mode of withdrawal, of turning one’s back, how might a back-leaning orientation support an open, receptive ethics of relation? Central to this enquiry is an attempt to explore how different linguistic practices might be developed in fidelity to the embodied experiences of dorsality: how the experiences of listening, languaging, even thinking, might be shaped differently through this embodied tilt of awareness and attention towards the back.
Suicide Interventions in Spain and Japan: A Comparative Systematic Review
Authors: Martínez-Rives Noelia Lucía , Martín Chaparro María del Pilar , Dhungel Bibha , Gilmour Stuart , Colman Rory D. , Kotera Yasuhiro
Published: April 2024

(1) Background: This systematic review presents an overview of psychological interventions in suicide published between 2013 and 2023 in Spain and Japan, sparked by Spain’s alarming recent increase in suicide rates and the potential exemplar of Japan’s reduction efforts. (2) Methods: Following the PRISMA checklist, the databases Web of Science, Scopus, PubMed, and PsycInfo were searched using the terms [(“suicide” OR “suicidal behavior” OR “suicidal attempt” OR “suicidal thought” OR “suicidal intention”) AND (“prevention” OR “intervention” OR “psychosocial treatment” OR “Dialectical Behavior Therapy” OR “Cognitive Therapy” OR “psychotherap*”)] AND [(“Spain” OR “Spanish”) OR (“Japan” OR “Japanese”)]. We included articles published in peer-reviewed academic journals, written in English, Spanish, and Japanese between 2013 and 2023 that presented, designed, implemented, or assessed psychological interventions focused on suicidal behavior. (3) Results: 46 studies were included, concerning prevention, treatment, and training interventions. The risk of bias was low in both Spanish and Japanese studies, despite the lack of randomization of the samples. We identified common characteristics, such as psychoeducation and coping skills. Assertive case management was only highlighted in Japan, making an emphasis on active patient involvement in his/her care plan. (4) Conclusions: The findings will help professionals to incorporate into their interventions broader, more comprehensive approaches to consider more interpersonal components.
Tools to Guide Radiation Oncologists in the Management of DCIS
Authors: Leonardi Maria Cristina , Zerella Maria Alessia , Lazzeroni Matteo , Fusco Nicola , Veronesi Paolo , Galimberti Viviana Enrica , Corso Giovanni , Dicuonzo Samantha , Rojas Damaris Patricia , Morra Anna , Gerardi Marianna Alessandra , Lorubbio Chiara , Zaffaroni Mattia , Vincini Maria Giulia , Orecchia Roberto , Jereczek-Fossa Barbara Alicja , Magnoni Francesca
Published: April 2024

Similar to invasive breast cancer, ductal carcinoma in situ is also going through a phase of changes not only from a technical but also a conceptual standpoint. From prescribing radiotherapy to everyone to personalized approaches, including radiotherapy omission, there is still a lack of a comprehensive framework to guide radiation oncologists in decision making. Many pieces of the puzzle are finding their place as high-quality data mature and are disseminated, but very often, the interpretation of risk factors and the perception of risk remain very highly subjective. Sharing the therapeutic choice with patients requires effective communication for an understanding of risks and benefits, facilitating an informed decision that does not increase anxiety and concerns about prognosis. The purpose of this narrative review is to summarize the current state of knowledge to highlight the tools available to radiation oncologists for managing DCIS, with an outlook on future developments.
Development and Validation of the Jordanian Diabetic Health Literacy Questionnaire: Enhancing Diabetes Management in Arabic-Speaking Populations
Authors: Al-Qerem Walid , Jarab Anan , Eberhardt Judith , Alasmari Fawaz , Alkaee Safa M. , Alsabaa Zein H.
Published: April 2024

(1) Background: Amidst the global rise in type 2 diabetes mellitus (T2DM), effective management of the disease has become increasingly important. Health literacy, particularly in non-English speaking populations, plays a crucial role in this management. To address the lack of suitable tools for Arabic-speaking diabetic patients, this study developed and validated the Jordanian Diabetic Health Literacy Questionnaire (JDHLQ). (2) Methods: A sample of 400 diabetic patients from Jordan, with a balance in gender, age, and educational background, was recruited from an endocrinology outpatient clinic. The JDHLQ, consisting of informative and communicative sections, underwent rigorous validation. Utilizing principal component analysis and Rasch analysis, the JDHL’s reliability and validity were evaluated. (3) Results: The results showed moderate proficiency in understanding and communicating diabetes-related information and confirmed the reliability and validity of the JDHLQ. (4) Conclusions: These findings emphasize the importance of culturally appropriate health literacy tools in enhancing patient understanding, engagement, and overall management of T2DM in Arabic-speaking communities.
Lung Cancer Surgery in Octogenarians: Implications and Advantages of Artificial Intelligence in the Preoperative Assessment
Authors: Bassi Massimiliano , Vaz Sousa Rita , Zacchini Beatrice , Centofanti Anastasia , Ferrante Francesco , Poggi Camilla , Carillo Carolina , Pecoraro Ylenia , Amore Davide , Diso Daniele , Anile Marco , De Giacomo Tiziano , Venuta Federico , Vannucci Jacopo
Published: April 2024

The general world population is aging and patients are often diagnosed with early-stage lung cancer at an advanced age. Several studies have shown that age is not itself a contraindication for lung cancer surgery, and therefore, more and more octogenarians with early-stage lung cancer are undergoing surgery with curative intent. However, octogenarians present some peculiarities that make surgical treatment more challenging, so an accurate preoperative selection is mandatory. In recent years, new artificial intelligence techniques have spread worldwide in the diagnosis, treatment, and therapy of lung cancer, with increasing clinical applications. However, there is still no evidence coming out from trials specifically designed to assess the potential of artificial intelligence in the preoperative evaluation of octogenarian patients. The aim of this narrative review is to investigate, through the analysis of the available international literature, the advantages and implications that these tools may have in the preoperative assessment of this particular category of frail patients. In fact, these tools could represent an important support in the decision-making process, especially in octogenarian patients in whom the diagnostic and therapeutic options are often questionable. However, these technologies are still developing, and a strict human-led process is mandatory.
Scrutinizing the Antimicrobial and Antioxidant Potency of European Cranberry Bush (Viburnum opulus L.) Extracts
Authors: Juhnevica-Radenkova Karina , Krasnova Inta , Seglina Dalija , Muizniece-Brasava Sandra , Valdovska Anda , Radenkovs Vitalijs
Published: April 2024

In the process of considering the documented health benefits of Viburnum opulus L. (V. opulus), including its anti-inflammatory and antioxidant activities, the present study was designed to qualitatively and quantitatively evaluate the biochemical profile and antimicrobial potency of four commercially available V. opulus extracts. These extracts were obtained from its flowers, bark, berries, and a mixture thereof by cold ultrasound-assisted extraction. An examination of the V. opulus extracts indicated a relative abundance of group compounds, such as phenolics, flavonoids, tannins, and anthocyanins, which are responsible for antioxidant activity (AOA). The widest range in all of the four group compounds was detected in the V. opulus extract sourced from berries, whereas the narrowest range was found in those obtained from flowers. The HPLC-ESI-TQ-MS/MS technique displayed relative fluctuations in the concentrations of individual amino acids (AAs) over the four V. opulus extracts. The prevalence of proline was marked in the flower-derived extract, which made up 63.3% of the total AAs, while aspartic and glutamic acids dominated in the berry-derived extract by contributing up to 29.2 and 24.4% to the total AA content, respectively. Profiling of the individual phenolic compounds disclosed the superiority of chlorogenic acid (up to 90.3%) in the berry and mixed extracts, as well as catechin (up to 57.7%) and neochlorogenic acid (11.1%) in the bark extract, which conveyed a remarkable contribution toward antimicrobial activity. The lowest content of individual phenolics was found in the flower extract. Owing to its substantially denser bioactive composition, the V. opulus berries and bark extracts exhibited markedly better AOA, which was pinpointed by three independent methods, i.e., DPPH•, FRAP, and ABTS•+, than those obtained from flowers or a mixture of V. opulus morphological parts. As part of the antimicrobial activity testing, the V. opulus extracts exhibited outstanding inhibitory activity and a homeopathic mode of action. The V. opulus extracts obtained from a mixture, bark, and berries were more active against 8 out of 19 selected test microorganisms at minimum inhibitory concentration (MIC) values that ranged from 0.24 to 0.49 µL mL−1. Overall, the extracts of V. opulus were found to be effective against Gram-positive and Gram-negative bacteria. However, their conceivable exploitation as functional or pharmaceutical ingredients must be further clarified within in vivo models.
Biomass Source of Biochar and Genetic Background of Tomato Influence Plant Growth and Development and Fruit Quality
Authors: Isaac Daylen , Labbancz June , Knowles Norman Richard , Tenic Elvir , Horgan Andrew , Ghogare Rishikesh , Dhingra Amit
Published: April 2024

Maintaining healthy soils and restoring marginal lands are necessary to ensure efficient food production and food security. Biochar, a porous carbon-rich material generated from the pyrolysis of organic feedstock, is receiving attention as a soil amendment that can potentially restore soil health and enhance crop yields. However, the physical and chemical properties of biochar are influenced by pyrolysis parameters and organic feedstock sources. These determine its interaction with the soil, influencing its impact on soil health and plant productivity. While most studies report the evaluation of one biochar and a single plant cultivar, the role of genetic background in responding to biochar as a soil amendment remains unexplored. The impact of six biochars on agronomic performance and fruit quality of three tomato (Solanum lycopersicum) cultivars was evaluated to test the hypotheses that (1) biochars derived from different feedstock sources would produce unique phenotypes in a single cultivar of tomato, and (2) single feedstock-derived biochar would produce different phenotypes in each of the three tomato cultivars. The data supported both hypotheses. This study demonstrated that plant genetic background and biomass source are important variables that must be considered for using biochar as a soil amendment.
A Genome-Wide Analysis of the WUSCHEL-Related Homeobox Transcription Factor Family Reveals Its Differential Expression Patterns, Response to Drought Stress, and Localization in Sweet Cherry (Prunus avium L.)
Authors: Deng Fei , Wang Hongming , An Xiaojuan , Uwamungu Jean Yves
Published: April 2024

The WUSCHEL-related homeobox (WOX) gene family has a critical effect on plant development and abiotic stress. However, there have been no genome-wide studies on WOX genes within sweet cherry (Prunus avium L.). In the present work, eight PavWOX genes were discovered within sweet cherry at the genome-wide level, and they were mapped to six chromosomes. Based on phylogenetic relationships, these genes were classified into three groups, with genes in one group having similar gene structures and conserved motifs. Meanwhile, the PavWOX genes possessed cis-acting elements and functions associated with hormone responses, stress responses, and development. As revealed by expression patterns, certain PavWOX genes are specifically expressed within tissues, suggesting that they may have unique functions. Additionally, the gene family expression patterns under drought stress were analyzed. PavWOX4, PavWOX5, PavWOX13A, and PavWOX13B had increased expressions upon drought stress. In addition, the transcription factor of PavWOX4 and PavWOX13A was localized in the nucleus, confirming the estimated results. Our findings lay the foundation for determining the expression patterns and functions of the PavWOX gene family within sweet cherry and shed more light on the underlying regulatory mechanisms.