bluuebunny/crossref_metadata_2025 huggingface dataset:
A feasibility study of Covid-19 detection using breath analysis by high-pressure photon ionization time-of-flight mass spectrometry
Authors: Zhang Peize , Ren Tantan , Chen Haibin , Li Qingyun , He Mengqi , Feng Yong , Wang Lei , Huang Ting , Yuan Jing , Deng Guofang , Lu Hongzhou
Published: September 2022

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) has caused a tremendous threat to global health. polymerase chain reaction (PCR) and antigen testing have played a prominent role in the detection of SARS-CoV-2-infected individuals and disease control. An efficient, reliable detection tool is still urgently needed to halt the global COVID-19 pandemic. Recently, the food and drug administration (FDA) emergency approved volatile organic component (VOC) as an alternative test for COVID-19 detection. In this case-control study, we prospectively and consecutively recruited 95 confirmed COVID-19 patients and 106 healthy controls in the designated hospital for treatment of COVID-19 patients in Shenzhen, China. Exhaled breath samples were collected and stored in customized bags and then detected by high-pressure photon ionization time-of-flight mass spectrometry for VOCs. Machine learning algorithms were employed for COVID-19 detection model construction. Participants were randomly assigned in a 5:2:3 ratio to the training, validation, and blinded test sets. The sensitivity (SEN), specificity (SPE), and other general metrics were employed for the VOCs based COVID-19 detection model performance evaluation. The VOCs based COVID-19 detection model achieved good performance, with a SEN of 92.2% (95% CI: 83.8%, 95.6%), a SPE of 86.1% (95% CI: 74.8%, 97.4%) on blinded test set. Five potential VOC ions related to COVID-19 infection were discovered, which are significantly different between COVID-19 infected patients and controls. This study evaluated a simple, fast, non-invasive VOCs-based COVID-19 detection method and demonstrated that it has good sensitivity and specificity in distinguishing COVID-19 infected patients from controls. It has great potential for fast and accurate COVID-19 detection.
Primary production assessment on eco-engineering infrastructures: English Channel case study
Authors: Claquin P , Vivier B , Navon M , Rusig A M , Mussio I , Chasselin L , Deloor M , Dauvin J C , Boutouil M , Orvain F
Published: September 2022

In the Marineff project, experimental eco-engineering dyke modules were immersed in 2020 in the Bay of Cherbourg (English Channel). Eco-engineering and classic dyke modules were compared regarding biodiversity and productivity. This paper presents the monitoring strategy of primary production assessment applied. Primary production assessment was performed by coupling various technics in order to consider all the compartments of primary producers present on the dykes and in the associated surrounding water mass. Seaweeds, microphytobenthos and phytoplankton were studied. Benthic chambers measuring oxygen and pCO2 under controlled light, and technics based on variable fluorescence were applied on eco-engineering and classic dyke modules. Preliminary results are presented in order to illustrate the expected indicator and methodology improvement and limits were discussed. The whole data set will allow us to explore the relationship between productivity and biodiversity as a function of the sites and of the nature of the infrastructure, eco-engineering or not. At this stage of our study we pointed out that the macroalgae were 7.9 times more productive than biofilm per surface on eco-engineering module whilst only 1.5 times on classic module. Smooth surface appeared to favour biofilm productivity at this stage of colonisation while rough surface drove more quickly the system to a production dominated by macroalgae.
QRS complex detection using stationary wavelet transform and adaptive thresholding
Authors: Sharma Neenu , Sunkaria Ramesh Kumar , Sharma Lakhan Dev
Published: September 2022

Purpose. Electrocardiogram (ECG) signal is a record of the electrical activity of the heart and contains important clinical data about cardiovascular-related misfunctioning. The goal of the present work is to develop an improved QRS detection algorithm for the detection of heart abnormalities. Methods. In this present work stationary wavelet transforms (SWT) based method has been proposed for precise detection of QRS complex with ‘sym2’ mother wavelet. The stationary wavelet transform is a systematic mathematical tool to decompose the signal without downsampling using scale analysis and provides high detection of QRS complex and accurate localization of signal components. In the proposed method four level of decomposition is applied and the initial thresholding value is computed by the maximum amplitude of scale one at level four in SWT coefficients without the zero-crossing amplitude detection method. The multi-layered dynamic thresholding method has been applied to detect the true R-peak values and locate the QRS complex in the ECG signal. Results. For evaluation of results, the presented methodology is assessed on MIT-BIH, QTDB, and Noise stress test databases. In MIT-BIH, the sensitivity = 99.88%, positive predictivity = 99.93%, accuracy = 99.80% and detection error rate = 0.18% is achieved. In NSTD database, sensitivity = 97.46%, positive predictivity = 94.20%, accuracy = 91.95% and detection error rate = 8.47% and in QTDB, sensitivity = 99.95%, positive predictivity = 99.90%, accuracy = 99.71% and detection error rate = 0.16% is executed. Conclusion. In the presented proposed methodology, the computation complexity is low and exhibits a simple technique rather than an empirical approach. The proposed technique corroborates the performance for the detection of QRS complex with improved accuracy.
A customizable, open-source Winston-Lutz system for multi-target, single isocentre radiotherapy
Authors: Oliver P A K , Wood T R , Baldwin L N
Published: September 2022

Objective. To present and share an open-source system (phantom and software) for verifying the targeting accuracy of linac-based, single-isocenter, multi-target radiotherapy. This quality assurance test extends the traditional Winston-Lutz test, which considers a single target located at isocentre. Approach. Plans for a 3D-printed phantom are provided, which can be customized to accommodate various target (BB) positions. Given BB positions and gantry/collimator/couch combinations, the software generates multi-leaf collimator positions to facilitate multi-target Winston-Lutz (MTWL) plan creation. The software determines deviations between detected and expected BB positions on MV images resulting from MTWL plan delivery. BBs are located using a Hough circle detection algorithm, which is modified to favour the detection of circles: (1) having a reasonable size, (2) that are contained within the radiation field, and (3) having reasonable pixel intensities. Validation was performed in two ways: (1) using synthetic data with zero targeting errors and (2) by measuring real linac targeting errors and comparing against results obtained using a commercial system. Main results. Validation using the synthetic data yielded a mean (maximum) absolute discrepancy of 0.11 mm (0.21 mm), which is comparable to the synthetic phantom resolution (0.2 mm). The mean (maximum) absolute discrepancy compared to the commercial system is 0.13 mm (0.43 mm). These values are similar to results obtained with repeated deliveries of the same MTWL plan with the same phantom setup. Both validation tests yield reasonable results and are therefore considered successful. The MTWL test was performed independently by three physicists on two linacs to investigate repeatability, resulting in a mean (maximum) absolute discrepancy of 0.14 mm (0.51 mm) among the various attempts. Significance. Successful completion of this quality assurance test, using our customizable and open-source system, provides confidence that multi-target, single isocentre radiotherapy treatments can be delivered with sufficient geometric accuracy according to the chosen tolerance level.
Physics-based representations for machine learning properties of chemical reactions
Authors: van Gerwen Puck , Fabrizio Alberto , Wodrich Matthew D , Corminboeuf Clemence
Published: September 2022

Physics-based representations constructed using only atomic positions and nuclear charges (also known as quantum machine learning, QML) allow for the reliable and efficient inference of molecular properties from training data. Chemistry is a science rooted in chemical reactions, naturally involving multiple molecular species. Here, we extend QML’s capabilities to include the prediction of reaction properties by defining reaction representations: representations taking as input multiple molecules participating in a reaction, each represented by their corresponding atomic charges and three-dimensional coordinates. Several reaction representations are constructed from established molecular ones and benchmarked on four datasets representative of thermodynamic or kinetic reaction properties. One of these, the Hydroform-22-TS dataset (2350 energy barriers), is introduced as part of this work. The relevant ingredients for a high-performing reaction representation are extracted and used to construct the Bond-Based Reaction Representation (

B
2

R
2

) for the prediction of quantum-chemical properties of chemical reactions. Finally, variations of

B
2

R
2

with varying representation size vs. performance are provided.
Massively scalable wavelength diverse integrated photonic linear neuron
Authors: van Niekerk Matthew , Rizzo Anthony , Rubio Hector , Leake Gerald , Coleman Daniel , Tison Christopher , Fanto Michael , Bergman Keren , Preble Stefan
Published: September 2022

As computing resource demands continue to escalate in the face of big data, cloud-connectivity and the internet of things, it has become imperative to develop new low-power, scalable architectures. Neuromorphic photonics, or photonic neural networks, have become a feasible solution for the physical implementation of efficient algorithms directly on-chip. This application is primarily due to the linear nature of light and the scalability of silicon photonics, specifically leveraging the wide-scale complementary metal-oxide-semiconductor manufacturing infrastructure used to fabricate microelectronics chips. Current neuromorphic photonic implementations stem from two paradigms: wavelength coherent and incoherent. Here, we introduce a novel architecture that supports coherent and incoherent operation to increase the capability and capacity of photonic neural networks with a dramatic reduction in footprint compared to previous demonstrations. As a proof-of-principle, we experimentally demonstrate simple addition and subtraction operations on a foundry-fabricated silicon photonic chip. Additionally, we experimentally validate an on-chip network to predict the logical 2 bit gates AND, OR, and XOR to accuracies of 96.8%, 99%, and 98.5%, respectively. This architecture is compatible with highly wavelength parallel sources, enabling massively scalable photonic neural networks.
Evaluating Occupational Noise Exposure as a Contributor to Injury Risk among Miners
Authors: Shkembi Abas , Smith Lauren M , Bregg Sandar , Neitzel Richard L
Published: September 2022

Objectives

This study: (i) assessed the relationship between noise exposure and injury risk, comprehensively adjusting for individual factors, psychosocial stressors, and organizational influences; (ii) determined the relative importance of noise on injuries; (iii) estimated the lowest observed adverse effect level (LOAEL) of noise on injury risk to determine the threshold of noise considered hazardous to injuries; and (iv) quantified the fraction of injuries that could be attributed to hazardous noise exposure.

Methods

In this cross-sectional study at 10 US surface mine sites, traditional mixed effects, Poisson regression, and boosted regression tree (BRT) models were run on the number of reported work-related injuries in the last year. The LOAEL of noise on injuries was identified by estimating the percent increase in work-related injuries at different thresholds of noise exposure using a counterfactual estimator through the BRT model. A population attributable fraction (PAF) was quantified with this counterfactual estimator to predict reductions in injuries at the LOAEL.

Results

Among 18 predictors of work-related injuries, mine site, perceived job safety, age, and sleepiness were the most important predictors. Occupational noise exposure was the seventh most important predictor. The LOAEL of noise for work-related injuries was a full-shift exposure of 88 dBA. Exposure ≥88 dBA was attributed to 20.3% (95% CI: 11.2%, 29.3%) of reported work-related injuries in the last year among the participants.

Conclusions

This study further supports hypotheses of a dose–response relationship between occupational noise exposure and work-related injuries, and suggests that exposures ≥88 dBA may increase injury risk in mining.
Coryanthes macrantha(Orchidaceae: Stanhopeinae) and their floral and extrafloral secretory structures: an anatomical and phytochemical approach
Authors: Casique Jorgeane Valéria , Soares Marcos Vinícius Batista , da Silva Edilson Freitas , Kikuchi Tatiani Yuriko , Andrade Eloisa Helena de Aguiar , Mastroberti Alexandra Antunes
Published: September 2022

Coryanthes is one of the most fascinating genera of Stanhopeinae (Orchidaceae) because of its complex pollination mechanism and the peculiar structures of its flowers. Although Coryanthes macrantha is widely studied, investigation of the secretory structures and floral biology is important to understand the mechanisms and ecology of pollination, which deserve attention despite the difficulties of collecting fertile material in nature. We conducted a morpho-anatomical analysis of the floral and extrafloral secretory structures of C. macrantha to better understand the secretory structures, contribute to the knowledge of its floral biology and/or pollination processes and understand the ecological function of these structures. The analysis revealed that C. macrantha has epidermal osmophores with unicellular papillae that were foraged by male Eulaema bees, floral nectaries in the sepals and extrafloral nectaries in the bracts. In both the floral and extrafloral nectaries, the nectar is exuded by the stomata. Azteca ants foraged the bract and sepal nectaries in pre-anthesis and post-anthesis. We also described the secretory epidermis of pleuridia, and the mode of secretion of osmophores and nectaries and found that they attract specific foraging agents.
Automatic Analysis of Constructional Diversity as a Predictor of EFL Students’ Writing Proficiency
Authors: Hwang Haerim , Kim Hyunwoo
Published: September 2022

One of the important components in second language (L2) development is to produce clause-level units of form–meaning pairings or argument structure constructions. Based on the usage-based constructionist approach that language development entails an ability to use more diverse, more complex, and less frequent constructions, this study tested whether constructional diversity and complexity predict L2 learners’ writing proficiency. Using a natural language processing tool called the Constructional Diversity Analyzer (CDA), we analyzed 3,284 essays produced by college EFL students in terms of the proportion of individual constructions and their diversity. Results from regression analyses showed that constructional diversity reliably predicted learner proficiency: essays with higher scores contained more diverse constructions. We also found that less frequent and more complex constructions made a stronger contribution to predicting the written proficiency levels. Based on the findings, we argue for the validity of constructional diversity and the use of individual constructions as reliable predictors of L2 writing proficiency and propose the application of the CDA for L2 writing assessment and instruction.
MetaboAnnotator: an efficient toolbox to annotate metabolites in genome-scale metabolic reconstructions
Authors: Thiele Ines , Preciat German , Fleming Ronan M T
Published: September 2022

Motivation

Genome-scale metabolic reconstructions have been assembled for thousands of organisms using a wide range of tools. However, metabolite annotations, required to compare and link metabolites between reconstructions, remain incomplete. Here, we aim to further extend metabolite annotation coverage using various databases and chemoinformatic approaches.

Results

We developed a COBRA toolbox extension, deemed MetaboAnnotator, which facilitates the comprehensive annotation of metabolites with database independent and dependent identifiers, obtains molecular structure files, and calculates metabolite formula and charge at pH 7.2. The resulting metabolite annotations allow for subsequent cross-mapping between reconstructions and mapping of, e.g., metabolomic data.

Availability and implementation

MetaboAnnotator and tutorials are freely available at https://github.com/opencobra.

Supplementary information

Supplementary data are available at Bioinformatics online.
Severe Mycobacterial Immune Reconstitution Inflammatory Syndrome (IRIS) in Advanced Human Immunodeficiency Virus (HIV) Has Features of Hemophagocytic Lymphohistiocytosis and Requires Prolonged Immune Suppression
Authors: Rocco Joseph M , Laidlaw Elizabeth , Galindo Frances , Anderson Megan , Rupert Adam , Higgins Jeanette , Sortino Ornella , Ortega-Villa Ana M , Sheikh Virginia , Roby Gregg , Kuriakose Safia , Lisco Andrea , Manion Maura , Sereti Irini
Published: September 2022

Background

People with HIV and mycobacterial infections can develop immune reconstitution inflammatory syndrome (IRIS) after starting antiretroviral therapy (ART). Severe mycobacterial IRIS has an overlapping clinical phenotype with hemophagocytic lymphohistiocytosis (HLH). We evaluated the pathophysiologic similarities between mycobacterial IRIS and HLH to identify clinical and immune predictors of mycobacterial IRIS severity.

Methods

HLH criteria were applied to a longitudinal cohort of 80 patients with HIV (CD4 <100 cells/µL) and mycobacterial infections. Participants were subdivided into IRIS meeting HLH criteria (HLH-IRIS), IRIS without HLH (IRIS), and those without IRIS (non-IRIS). Clinical outcomes were evaluated by regression analyses. Soluble biomarkers and T-cell subsets were assessed at baseline and IRIS-equivalent time points.

Results

HLH-IRIS patients required corticosteroids more frequently (OR: 21.5; 95%CI: 5.6–114.8) and for longer duration (21.2; 95%CI: 10.7–31.7 weeks) than those not meeting HLH criteria. Utilizing decision tree analyses, hemoglobin <9.2 g/dL was the best predictor of HLH-IRIS before ART, whereas ferritin, CXCL9 and sCD25 were most diagnostic for HLH at IRIS onset. At the IRIS timepoint, but not baseline, HLH-IRIS patients had lower regulatory and higher activated T cells along with greater production of IFNγ–IL-18 axis biomarkers compared with both IRIS and non-IRIS groups. Principal component analysis corroborated the distinct clustering of HLH-IRIS patients.

Conclusions

Severe mycobacterial IRIS and HLH have an overlapping pathogenesis involving IFNγ and unopposed T-cell activation causing severe inflammatory disease clinically distinguished by hyperferritinemia (hyperferritinemic IRIS [FIRIS]). Hemoglobin, ferritin, CXCL9, and sCD25 identify high-risk patients and may improve risk stratification and therapeutic strategies for mycobacterial IRIS.
Severely Restricting Abortion Threatens Equitable Health Outcomes for People With Human Immunodeficiency Virus
Authors: Hadley Megan , Powell Anna
Published: September 2022

Equitable access to abortion is a critical component of reproductive care. Women with human immunodeficiency virus (HIV) in the United States are disproportionately Black and will be disproportionately affected by abortion bans following the Supreme Court's decision to overturn Roe v Wade. We argue that this decision is directly in conflict with the National HIV/AIDS Strategies and Centers for Disease Control and Prevention's goals to eliminate perinatal HIV transmission.
ECCO Topical Review: Roadmap to Optimal Peri-Operative Care in IBD
Authors: Sebastian Shaji , Segal Jonathan P , Hedin Charlotte , Pellino Gianluca , Kotze Paulo Gustavo , Adamina Michel , Campmans-Kuijpers Marjo , Davies Justin , de Vries Annemarie C , Casbas Ana Gutiérrez , El-Hussuna Alaa , Juillerat Pascal , Meade Susanna , Millán Monica , Spinelli Antonino
Published: September 2022

Background and aims

Despite the advances in medical therapies, a significant proportion of patients with inflammatory bowel diseases [IBD] require surgical intervention. This Topical Review aims to offer expert consensus practice recommendations for peri-operative care to optimize outcomes of IBD patients who undergo surgery.

Methods

A multidisciplinary panel of IBD healthcare providers systematically reviewed aspects relevant to peri-operative care in IBD. Consensus statements were developed using Delphi methodology.

Results

A total of 20 current practice positions were developed following systematic review of the current literature covering use of medication in the peri-operative period, nutritional assessment and intervention, physical and psychological rehabilitation and prehabilitation, and immediate postoperative care.

Conclusion

Peri-operative planning and optimization of the patient are imperative to ensure favourable outcomes and reduced morbidity. This Topical Review provides practice recommendations applicable in the peri-operative period in IBD patients undergoing surgery.
C4-dicarboxylate metabolons: interaction of C4-dicarboxylate transporters of Escherichia coli with cytosolic enzymes
Authors: Schubert Christopher , Kim Nam Yeun , Unden Gottfried , Kim Ok Bin
Published: September 2022

Metabolons represent the structural organization of proteins for metabolic or regulatory pathways. Here, the interaction of fumarase FumB, aspartase AspA, and L-tartrate dehydratase TtdAB with the C4-dicarboxylate (C4-DC) transporters DcuA, DcuB, DcuC, and the L-tartrate transporter TtdT of Escherichia coli was tested by a bacterial two-hybrid (BACTH) assay in situ, or by co-chromatography using mSPINE (membrane Streptavidin protein interaction experiment). From the general C4-DC transporters, DcuB interacted with FumB and AspA, DcuA with AspA, whereas DcuC interacted with neither FumB nor AspA. Moreover, TtdT did not interact with TtdAB. The fumB-dcuB, the dcuA-aspA, and the ttdAB-ttdT genes encoding the respective proteins colocalize on the genome and each pair of genes forms cotranscripts, whereas the dcuC gene lies alone. The data suggest the formation of DcuB/FumB and DcuB/AspA metabolons for the uptake of L-malate, or L-aspartate, and their conversion to fumarate for fumarate respiration and excretion of the product succinate. The DcuA/AspA metabolon catalyzes uptake and conversion of L-aspartate to fumarate coupled to succinate excretion. The DcuA/AspA metabolon provides ammonia at the same time for nitrogen assimilation (ammonia shuttle). On the other hand, TtdT and TtdAB are not organized in a metabolon. Reasons for the formation (DcuA/AspA, DcuB/FumB, and DcuB/AspA) or nonformation (DcuC, TtdT, and TtdAB) of metabolons are discussed based on their metabolic roles.
Concentrations of mesophilic bacteria in a poultry farm over two fattening periods focusing on the presence of staphylococci and enterococci
Authors: Haas Doris , Miskovic Tea , Fritz Theresa , Galler Herbert , Habib Juliana , Köck Sabine , Kropsch Michael , Pless Peter , Stonitsch Martin , Zentner Eduard , Reinthaler Franz F
Published: September 2022

The increasing animal numbers have a potential impact on the air quality of stables. The aim of this study was to assess the microbial load in the barn air from the day of entry of the chickens to the day of removal for slaughter. A total of 10 measurements in two fattening periods were conducted in a poultry farm with a capacity of 400 chickens in Styria, Austria. The samples were collected with an Air-Sampling Impinger for the investigation of mesophilic bacteria, staphylococci and enterococci. Chicken skin swab samples were collected to detect Staphylococcus aureus. The total colony forming units per cubic meter of mesophilic bacteria of the first measurement series of period I was 7.8 × 104 and increased to 1.4 × 108 at the end and at the fattening period II it increased from 2.5 × 105 to 4.2 × 107. In the measurement series of the fattening period I, the concentration of Staphylococcus spp. increased from 0 to 4.9 × 107 CFUs/m3 and from 0 to 2.1 × 107 CFUs/m3 in the fattening period II. Staphylococcus aureus could not be found on the chicken skin. An interesting finding was the increase of staphylococci while the intestinal enterococci were not detectable in the air of the barn toward the end of both fattening periods.
Identification of 5 Potential Predictive Biomarkers for Alzheimer’s Disease by Integrating the Unified Test for Molecular Signatures and Weighted Gene Coexpression Network Analysis
Authors: Zhou Siquan , Ma Guochen , Luo Hang , Shan Shufang , Xiong Jingyuan , Cheng Guo
Published: September 2022

Background

Previous transcriptome-wide association study (TWAS) has documented 21 genes associated with Alzheimer’s disease (AD) risk, but the predictive biomarkers remain unexplored.

Methods

TWAS leveraging the unified test for molecular signatures (UTMOST) was performed in 75,000 cases and 420,000 controls with 10 brain tissue gene expression references. Weighted gene coexpression network analysis (WGCNA) was conducted in GSE5281 and GSE48350 data sets containing 167 AD samples and 247 controls. Random forest (RF) analysis was applied to screen the potential predictive biomarkers based on overlapping genes identified by TWAS and WGCNA, followed by comprehensive bioinformatic analyses with differential gene expression, functional enrichment, and correlation with immune cells. A nomogram was established to verify the predictive power of the identified biomarkers.

Results

TWAS revealed 78 candidate genes (p < 2.89 × 10−6). In WGCNA turquoise module, 3 718 AD-related genes were screened. RF identified 5 predictive biomarkers (FAM71E1, DDB2, AP4M1, GPR4, DOC2A), which are enriched in the global genome nucleotide excision repair pathway and associated with immune cell designations “Natural.killer.T.cell,” “Memory.B.cell,” “T.follicular.helper.cell,” “Neutrophil,” and “MDSC.” The nomogram based on the 5 markers showed a high predictive power.

Conclusion

Five potential predictive biomarkers for AD were identified, providing new insights into the pathogenesis and etiology of AD.
Bernstein of Leigh v Skyviews & General Ltd [1978] QB 479, High Court (Queen’s Bench Division)
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Bernstein of Leigh v Skyviews & General Ltd [1978] QB 479, High Court (Queen’s Bench Division). The document also includes supporting commentary from author Aruna Nair.
Cobbe v Yeoman’s Row Management Ltd [2008] UKHL 55, House of Lords
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Cobbe v Yeoman’s Row Management Ltd [2008] UKHL 55, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Lloyds Bank plc v Rosset [1991] 1 AC 107, House of Lords
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Lloyds Bank plc v Rosset [1991] 1 AC 107, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Stack v Dowden [2007] UKHL 17, House of Lords
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Stack v Dowden [2007] UKHL 17, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Thorner v Major [2009] UKHL 18, House of Lords
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Thorner v Major [2009] UKHL 18, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Abbey National Building Society v Cann [1991] 1 AC 56, House of Lords
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Abbey National Building Society v Cann [1991] 1 AC 56, House of Lords. The document also includes supporting commentary from author Aruna Nair.
City of London Building Society v Flegg [1988] AC 54, House of Lords
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in City of London Building Society v Flegg [1988] AC 54, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Midland Bank Trust Co. Ltd v Green [1981] AC 513, House of Lords
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Midland Bank Trust Co. Ltd v Green [1981] AC 513, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Manchester Airport v Dutton [2000] 1 QB 133, Court of Appeal
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Manchester Airport v Dutton [2000] 1 QB 133, Court of Appeal. The document also includes supporting commentary from author Aruna Nair.
AG Securities v Vaughan; Antoniades v Villiers [1990] 1 AC 417, House of Lords
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in AG Securities v Vaughan; Antoniades v Villiers [1990] 1 AC 417, House of Lords. The document also includes supporting commentary from author Aruna Nair.
Berrisford Housing Co-operative v Mexfield [2011] UKSC 52, Supreme Court
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Berrisford Housing Co-operative v Mexfield [2011] UKSC 52, Supreme Court. The document also includes supporting commentary from author Aruna Nair.
Cheltenham & Gloucester plc v Krausz [1997] 1 WLR 1558, Court of Appeal
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Cheltenham & Gloucester plc v Krausz [1997] 1 WLR 1558, Court of Appeal. The document also includes supporting commentary from author Aruna Nair.
Burgess v Rawnsley [1975] 3 All ER 142, Court of Appeal
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Burgess v Rawnsley [1975] 3 All ER 142, Court of Appeal. The document also includes supporting commentary from author Aruna Nair.
Mortgage Corporation v Shaire [2001] Ch 743, High Court (Chancery Division)
Authors: Nair Aruna
Published: September 2022

Essential Cases: Land Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Mortgage Corporation v Shaire [2001] Ch 743, High Court (Chancery Division). The document also includes supporting commentary from author Aruna Nair.
Dunnage v Randall [2016] QB 639
Authors: Purshouse Craig
Published: September 2022

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Dunnage v Randall [2016] QB 639. The document also included supporting commentary from author Craig Purshouse.
Reeves v Commissioner of Police of the Metropolis [2000] 1 AC 360
Authors: Purshouse Craig
Published: September 2022

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Reeves v Commissioner of Police of the Metropolis [2000] 1 AC 360. The document also included supporting commentary from author Craig Purshouse.
Barclays Bank Plc v Various Claimants [2020] UKSC 13
Authors: Purshouse Craig
Published: September 2022

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Barclays Bank Plc v Various Claimants [2020] UKSC 13. The document also included supporting commentary from author Craig Purshouse.
Lister v Hesley Hall Ltd [2002] 1 AC 215
Authors: Purshouse Craig
Published: September 2022

Essential Cases: Tort Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Lister v Hesley Hall Ltd [2002] 1 AC 215. The document also included supporting commentary from author Craig Purshouse.
McPhail v Doulton, Re Baden’s Deed Trusts (No 1) [1971] AC 424, House of Lords
Authors: Whayman Derek
Published: September 2022

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in McPhail v Doulton, Re Baden’s Deed Trusts (No 1) [1971] AC 424, House of Lords. The document also includes supporting commentary from author Derek Whayman.
Schmidt v Rosewood Trust [2003] UKPC 26, Privy Council
Authors: Whayman Derek
Published: September 2022

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Schmidt v Rosewood Trust [2003] UKPC 26, Privy Council. The document also includes supporting commentary from author Derek Whayman.
Barclays Bank Ltd v Quistclose Investments Ltd [1970] AC 567, House of Lords
Authors: Whayman Derek
Published: September 2022

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Barclays Bank Ltd v Quistclose Investments Ltd [1970] AC 567, House of Lords. The document also includes supporting commentary from author Derek Whayman.
Lloyds Bank Plc v Rosset [1991] 1 AC 107, House of Lords
Authors: Whayman Derek
Published: September 2022

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Lloyds Bank Plc v Rosset [1991] 1 AC 107, House of Lords. The document also includes supporting commentary from author Derek Whayman.
Williams v Central Bank of Nigeria [2014] UKSC 10, Supreme Court
Authors: Whayman Derek
Published: September 2022

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Williams v Central Bank of Nigeria [2014] UKSC 10, Supreme Court. The document also includes supporting commentary from author Derek Whayman.
Central London Property Trust Ltd v High Trees House Ltd [1947] KB 130, King’s Bench Division
Authors: Whayman Derek
Published: September 2022

Essential Cases: Equity & Trusts provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Central London Property Trust Ltd v High Trees House Ltd [1947] KB 130, King’s Bench Division. The document also includes supporting commentary from author Derek Whayman.
DPP v Majewski [1977] AC 443, House of Lords
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in DPP v Majewski [1977] AC 443, House of Lords. The document also included supporting commentary from author Jonathan Herring.
R v MD [2004] EWCA Crim 1391, Court of Appeal
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v MD [2004] EWCA Crim 1391, Court of Appeal. The document also included supporting commentary from author Jonathan Herring.
R v Woollin [1999] 1 AC 82, House of Lords
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v Woollin [1999] 1 AC 82, House of Lords. The document also included supporting commentary from author Jonathan Herring.
R v Evans (Gemma) [2009] EWCA Crim 650, Court of Appeal
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v Evans (Gemma) [2009] EWCA Crim 650, Court of Appeal. The document also included supporting commentary from author Jonathan Herring.
R v Ireland; R v Burstow [1998] AC 147, House of Lords
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v Ireland; R v Burstow [1998] AC 147, House of Lords. The document also included supporting commentary from author Jonathan Herring.
R (Monica) v DPP [2018] EWHC 3508 (QB), Queen’s Bench Division
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R (Monica) v DPP. The document also included supporting commentary from author Jonathan Herring.
R v Melin [2019] EWCA Crim 557, Court of Appeal
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v Melin [2019] EWCA Crim 557, Court of Appeal. The document also included supporting commentary from author Jonathan Herring.
Bratty v Attorney-General for Northern Ireland [1963] AC 386, House of Lords
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Bratty v Attorney-General for Northern Ireland [1963] AC 386, House of Lords. The document also included supporting commentary from author Jonathan Herring.
R v Shivpuri [1987] AC 1, House of Lords
Authors: Herring Jonathan
Published: September 2022

Essential Cases: Criminal Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in R v Shivpuri [1987] AC 1, House of Lords. The document also included supporting commentary from author Jonathan Herring.
Adams v Lindsell [1818] EWHC KB J59; (1818) 1 B & Ald 681; (1818) 106 ER 250
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Adams v Lindsell (1818) 106 ER 250. The document also includes supporting commentary from author Nicola Jackson.
Butler Machine Tool Co. Ltd v Ex-Cell-O Corporation (England) Ltd [1979] 1 WLR 401, Court of Appeal
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Butler Machine Tool Co. Ltd v Ex-Cell-O Corporation (England) Ltd [1979] 1 WLR 401. The document also includes supporting commentary from author Nicola Jackson.
Dickinson v Dodds (1876) 2 Ch D 463
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Dickinson v Dodds (1876) 2 Ch D 463. The document also includes supporting commentary from author Nicola Jackson.
Hyde v Wrench (1840) 49 ER 132
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Hyde v Wrench [1840] EWHC Ch J90; (1840) 49 ER 132; (1840) 3 Beav 334. The document also includes supporting commentary from author Nicola Jackson.
Rock Advertising Ltd v MWB Business Exchange Centres Ltd [2018] UKSC 24
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Rock Advertising Ltd v MWB Business Exchange Centres Ltd [2018] UKSC 24. The document also includes supporting commentary from author Nicola Jackson.
Williams v Roffey Bros & Nicholls (Contractors) Ltd [1991] 1 QB 1
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Williams v Roffey Bros & Nicholls (Contractors) Ltd [1991] 1 QB 1. The document also includes supporting commentary from author Nicola Jackson.
Great Peace Shipping Ltd v Tsavliris Salvage (International) Ltd [2002] EWCA Civ 1407
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Great Peace Shipping Ltd v Tsavliris Salvage (International) Ltd [2002] EWCA Civ 1407. The document also includes supporting commentary from author Nicola Jackson.
Shogun Finance Ltd v Hudson [2003] UKHL 62
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Shogun Finance Ltd v Hudson [2003] UKHL 62. The document also includes supporting commentary from author Nicola Jackson.
Times Travel (UK) Ltd v Pakistan International Airlines Corporation [2021] UKSC 40; [2021] 3 WLR 727
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Times Travel (UK) Ltd v Pakistan International Airlines Corporation [2021] UKSC 40; [2021] 3 WLR 727. The document also includes supporting commentary from author Nicola Jackson.
George Mitchell (Chesterhall) Ltd v Finney Lock Seeds Ltd [1983] 2 AC 803
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in George Mitchell (Chesterhall) Ltd v Finney Lock Seeds Ltd [1983] 2 AC 803. The document also includes supporting commentary from author Nicola Jackson.
Goodlife Foods Ltd v Hall Fire Protection Ltd [2018] EWCA Civ 1371
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Goodlife Foods Ltd v Hall Fire Protection Ltd [2018] EWCA Civ 1371. The document also includes supporting commentary from author Nicola Jackson.
Arnold v Britton [2015] UKSC 36
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Arnold v Britton [2015] UKSC 36. The document also includes supporting commentary from author Nicola Jackson.
Davis Contractors Ltd v Fareham Urban District Council [1956] AC 696
Authors: Jackson Nicola
Published: September 2022

Essential Cases: Contract Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Davis Contractors Ltd v Fareham Urban District Council [1956] AC 696. The document also includes supporting commentary from author Nicola Jackson.
Commission v Council (‘Environmental crimes’) (Case C-176/03), EU:C:2005:542, [2005] ECR I-7879, 13 September 2005
Authors: O'Meara Noreen
Published: September 2022

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Commission v Council (‘Environmental crimes’) (Case C-176/03), EU:C:2005:542, [2005] ECR I-7879, 13 September 2005. The document also includes supporting commentary from author Noreen O’Meara.
Unión de Pequeños Agricultores v Council of the European Union (Case C-50/00 P), EU:C:2002:462, [2002] ECR I-6677, 25 July 2002
Authors: O'Meara Noreen
Published: September 2022

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Unión de Pequeños Agricultores v Council of the European Union (Case C-50/00 P), EU:C:2002:462, [2002] ECR I-6677, 25 July 2002. The document also includes supporting commentary from author Noreen O’Meara.
Association belge des Consommateurs Test-Achats and others v Council (Case C-236/09), EU:C:2011:100, [2011] ECR I-773, 1 March 2011
Authors: O'Meara Noreen
Published: September 2022

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Association belge des Consommateurs Test-Achats and others v Council (Case C-236/09), EU:C:2011:100, [2011] ECR I-773, 1 March 2011. The document also includes supporting commentary from author Noreen O’Meara.
Prosecutor v Hans Åkerberg Fransson (Case C-617/10), EU:C:2013:105, [2013] 2 CMLR 46, 26 February 2013
Authors: O'Meara Noreen
Published: September 2022

Essential Cases: EU Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Prosecutor v Hans Åkerberg Fransson (Case C-617/10), EU:C:2013:105, [2013] 2 CMLR 46, 26 February 2013. The document also includes supporting commentary from author Noreen O’Meara.
Handyside v United Kingdom (1979–80) 1 EHRR 737, European Court of Human Rights
Authors: Webb Thomas E.
Published: September 2022

Essential Cases: Public Law provides a bridge between course textbooks and key case judgments. This case document summarizes the facts and decision in Handyside v United Kingdom (1979-80) 1 EHRR 737, European Court of Human Rights. This case concerned a book which breached the Obscene Publications Act 1959. The publisher, Handyside, contended that the domestic law (the 1959 Act) breached his Article 10 rights under the European Convention on Human Rights. The case introduced the concept of the ‘margin of appreciation’ accorded to states as regards the implementation of convention rights. The case predates the passage of the Human Rights Act 1998. The document also includes supporting commentary and questions from author Thomas Webb.