bluuebunny/crossref_metadata_2025 huggingface dataset:
Cost-neutral reduction of infection risk in picker-to-parts warehousing systems
Authors: Löffler Maximilian , Schneider Michael , Žulj Ivan
Published: November 2022

The rapid and severe outbreak of COVID-19 caused by SARS-CoV-2 has heavily impacted warehouse operations around the world. In particular, picker-to-parts warehousing systems, in which human pickers collect requested items by moving from picking location to picking location, are very susceptible to the spread of infection among pickers because the latter generally work close to each other. This paper aims to mitigate the risk of infection in manual order picking. Given multiple pickers, each associated with a given sequence of picking tours for collecting the items specified by a picking order, we aim to execute the tours in a way that minimizes the time pickers simultaneously spend in the same picking aisles, but without changing the distance traveled by the pickers. To achieve this, we exploit the degrees of freedom induced by the fact that picking tours contain cycles which can be traversed in both directions, i.e., at the entry to each of these cycles, the decision makers can decide between the two possible directions. We formulate the resulting picking tour execution problem as a mixed integer program and propose an efficient iterated local search heuristic to solve it. In extensive numerical studies, we show that an average reduction of 50% of the total temporal overlap between pickers can be achieved compared to randomly executing the picking tours. Moreover, we compare our approach to a zone picking approach, in which infection risk between pickers can be almost eliminated. However, compared to our approach, the results show that the zone picking approach increases the makespan by up to 1066%.
Combined ultrasonography and CT for prognosis and predicting clinical outcomes of patients with pseudomyxoma peritonei
Authors: Han Xuedi , Zhang Qian , Zhou Nan , Ma Ruiqing , Wang Jiajun , Zhai Xichao , Cui Bin , Lu Yiyan , Liang Lei
Published: November 2022

Objectives

This study aimed to identify the diagnostic accuracy of combined ultrasonography (US) and computed tomography (CT) in evaluating the tumor burden of pseudomyxoma peritonei (PMP). Besides, we assessed the ability of this combination to predict the likelihood of complete resection.

Methods

This retrospective study involved 504 patients diagnosed with PMP and scheduled for cytoreduction surgery. We compared tumor burden—quantified as peritoneal cancer index (PCI) by preoperative US and CT (US-CT-PCI)—with surgical findings. Next, we assessed the prognostic value of US-CT PCI and imaging features in determining the completeness of cytoreduction (CCR) score using multivariate analysis.

Results

US-CT PCI demonstrated a high PCI evaluation accuracy under moderate tumor burden. Higher US-CT PCI could predict incomplete resection. In addition, we identified imaging features such as mesenteric involvement as an independent predictor of incomplete resection (hazard ratio (HR) = 2.006; p = 0.007).

Conclusions

US-CT PCI allowed us to predict the completeness of cytoreductive surgery in patients with PMP. Moreover, the combined US and CT imaging detected several features indicating incomplete cytoreduction.

Key Points

• Ultrasonography (US) can act as a complementary diagnostic modality in peritoneal cancer index (PCI) evaluation by combining CT in the small bowel area and US in the abdominal area.

• A modified peritoneal cancer index (US-CT PCI) helps preoperatively evaluate tumor burden with high accuracy and allows to predict incomplete resection.

• US-CT PCI of 20 or above and the involvement of particular structures such as mesentery, independently indicate incomplete resection.
Time effect on cardiometabolic risk indicators in patients with bipolar disorder: a longitudinal case–control study
Authors: Najar Hemen , Joas Erik , Pålsson Erik , Landén Mikael
Published: November 2022

Individuals with bipolar disorder are at increased risk for cardiovascular diseases. Most studies have described increases in cardiometabolic risk indicators (CMRIs) using clinical cut-off values. Further, there are no longitudinal studies on CMRIs. We aimed to investigate continuous measures of CMRIs in individuals with bipolar disorder and controls using both cross-sectional and longitudinal data. We used data from the Swedish St. Göran Bipolar project. Study individuals were examined at baseline and after a median of 6 and 7 years for the control and patient group, respectively. Data were collected December 2005–December 2020. The cohort included 281 individuals with bipolar disorder (mean age 39 years, 59% women) and 114 controls (mean age 38 years, 55% women). Of those, 155 patients and 74 controls also provided follow-up data. At baseline, individuals with bipolar disorder had significantly higher mean values of waist-to-hip ratio (WHR) (β = 0.142, p = 0.001), body mass index (β = 0.150, p = 0.006), plasma triacylglycerol (TAG) (β = 0.218, p < 0.001), total/plasma high-density lipoprotein-cholesterol (TChol/HDL-C) ratio (β = 0.103, p = 0.03), TAG/HDL-C ratio (β = 0.151, p = 0.006), and non-HDL-C (β = 0.168, p = 0.001) than controls. Most CMRIs remained higher in the patient group at follow-up. The difference between patients and controls increased over time for WHR (0.005 unit/year, p < 0.001), and systolic (1.1 mm Hg/year, p = 0.002) and diastolic (0.8 mm Hg/year, p < 0.001) blood pressure. Individuals with bipolar disorder displayed persistently higher levels of nearly all included CMRIs. Over time, a subset of CMRIs worsened in patients relative to controls. This suggests that active measures to counter cardiovascular risk in persons with bipolar disorder should be considered.
Efficacy of selective laser trabeculoplasty on lowering intraocular pressure fluctuations and nocturnal peak intraocular pressure in treated primary open-angle glaucoma patients
Authors: Pillunat Karin R. , Kocket Greta A. , Herber Robert , Jasper Carolin S. , Lenk Janine , Pillunat Lutz E.
Published: November 2022

Purpose

To investigate the efficacy of adjunctive selective laser trabeculoplasty (SLT) in reducing 24-h intraocular pressure (IOP) fluctuations and nocturnal IOP peaks.

Methods

In this prospective interventional case series, 157 medically treated eyes of 157 patients with primary open-angle glaucoma (POAG) who were assigned SLT to further reduce IOP were consecutively included. Each patient had a complete glaucoma work-up and 24-h IOP monitoring (6 measurements, including one in the supine position) taken before and on average 6 months after SLT. The main outcome measures were the reduction of 24-h IOP fluctuations and nocturnal peak IOP. Secondary outcome measures were success rates, factors influencing the reduction of high 24-h IOP fluctuations and nocturnal peak IOP, complications, and severe adverse events.

Results

Medicated mean 24-h IOP (mmHg) was statistically significantly reduced from 15.1 ± 2.6 to 13.8 ± 2.4 (P < 0.001) and IOP fluctuations from 6.5 ± 2.7 to 5.4 ± 2.6 (P < 0.001) 6 months after SLT. Ninety-four eyes (59.9%) initially had high IOP fluctuations (more than 5 mmHg). These were reduced from 8.1 ± 2.3 to 5.6 ± 2.7 at 6 months (P < 0.001). Fifty-two eyes (55.3%) had fluctuations below 5 mmHg post-SLT which was defined as success. Fifty-one patients (32.5%) had nocturnal IOP peaks. In these cases, nocturnal IOP was reduced by 19.2% from 20.1 ± 3.4 to 16.2 ± 3.3 mmHg at 6 months (P = 0.001).

Conclusions

The current study demonstrates that adjunctive SLT not only reduces mean 24-h IOP in treated POAG patients, but also has an additional benefit in reducing IOP fluctuations and nocturnal peak IOP.

Trial registration

Clinical trial registration: NCT02959242.
Is there a molecular basis for solvent drag in the renal proximal tubule?
Authors: Günzel Dorothee
Published: November 2022

The concept of solvent drag, i.e., water and solutes sharing the same pore and their transport being frictionally coupled, was first proposed in the early 1950s. During the following decades, it was applied to transport processes across cell membranes as well as transport along the paracellular pathway. Water-driven solute transport was proposed as the major mechanism for electrolyte and nutrient absorption in the small intestine and for Cl− and HCO3− reabsorption in the renal proximal tubule. With the discovery of aquaporins as transcellular route for water transport and the claudin protein family as the major determinant of paracellular transport properties, new mechanistic insights in transepithelial water and solute transport are emerging and call for a reassessment of the solvent drag concept. Current knowledge does not provide a molecular basis for relevant solvent drag-driven, paracellular nutrient, and inorganic anion (re-)absorption. For inorganic cation transport, in contrast, solvent drag along claudin-2-formed paracellular channels appears feasible.
Accurate gingival recession quantification using 3D digital dental models
Authors: Dritsas Konstantinos , Halazonetis Demetrios , Ghamri Mohammed , Sculean Anton , Katsaros Christos , Gkantidis Nikolaos
Published: November 2022

Objectives

To develop and validate a method for accurate quantitative assessment of gingival recessions based on superimposition of serial 3D digital models.

Materials and methods

Gingival recessions of mild (0.5–2 mm) and increased (3–7 mm) severity were simulated on stone casts and surface models were created. The outlines of the gingival margins of the mild (A) and severe recessions (B) were compared to the original gingival margins following 3D best fit superimposition through a gold standard technique (GS), which used intact adjacent structures, and the tested method (CC), which used single tooth crowns at the position of recessions, as superimposition reference. The primary outcome was the distance between the most apical point of each corresponding gingival margin along the respective tooth long axis.

Results

For mild recessions, the median difference of the test methods (CC_A) from the reference method (GS_A) was 0.008 mm (IQR: 0.093; range: − 0.143, 0.147). For severe recessions, the median difference of the test method (CC_B) from the reference method (GS_B) was 0.009 mm (IQR: 0.091; range: − 0.170, 0.198). The proposed method (CC) showed very high intra- and inter-operator reproducibility (median: 0.025 and 0.033 mm, respectively).

Conclusions

The suggested method offers highly accurate monitoring of gingival margin changes and diagnosis of gingival recessions using 3D digital dental models. The method is applicable irrespective of changes in tooth position or form, allowing for assessments over any time span.

Clinical relevance

The accurate detection and visualization of gingival margin changes in 3D will enhance diagnosis and patient-doctor communication.
Effectiveness of lasers and aPDT in elimination of intraoral halitosis: a systematic review based on clinical trials
Authors: Woźniak Agnieszka , Matys Jacek , Grzech-Leśniak Kinga
Published: November 2022

In recent years, there has been increasing interest in research showing positive results in antimicrobial photodynamic therapy (aPDT) and laser therapy (LT) in dentistry. The authors of this review tried to answer the question: “Is the effectiveness of lasers and aPDT in the elimination of intraoral halitosis possible?” For this purpose, the electronic database of PubMed and Cochrane Library were searched until September 2021 using a combination of different keywords: (bad breath OR fetor ex ore OR halitosis OR oral malodor) AND (laser OR PDT OR PACT OR photodynamic inactivation OR photodynamic therapy OR photodynamic antimicrobial chemotherapy). Initially, 83 studies were identified. A total of 9 articles were qualified after the application of the eligibility criteria. Eight works concerned aPDT treatment, and only one dedicated to the Er,Cr:YSGG laser. A significant reduction in halitosis occurred immediately after both LT and aPDT. The review found the confirmation of the effectiveness of laser therapy in reducing the number of volatile sulfur compounds (VSC) and the amount of anaerobic bacteria responsible for VSC formation. In most studies, a positive effect was observed for a 1-week follow-up. Laser therapy (aPDT, Er,Cr:YSGG) effectively eliminates microorganisms that produce volatile compounds and can effectively eliminate bad breath for the longer period of time than traditional methods of combatting this ailment.
Climate impact chains for envisaging climate risks, vulnerabilities, and adaptation issues
Authors: Estoque Ronald C. , Ooba Makoto , Togawa Takuya , Yoshioka Akira , Gomi Kei , Nakamura Shogo , Tsuji Takashi , Hijioka Yasuaki , Watanabe Manabu , Kitahashi Midori
Published: November 2022

Planning adaptations to climate change require an understanding of how climate-related impacts cascade across sectors of society. Equally important is the need to engage stakeholders in discussions of climate-related impacts, risks, vulnerabilities, and adaptation issues. The impact chain (IC) approach, which emerged about a decade ago, can be used to reveal potential climate risks and vulnerabilities and to visualize how climate-related impacts may propagate as cascades. Here, we discuss the composition, key features, and potentials of the IC approach. Drawing from actual experience, we discuss some important factors that must be considered in the development of ICs via stakeholder participation. Such considerations are centered on the need for clarity with respect to the conceptual framing of relevant ICs, the need to allocate ample time for the development of ICs, and the need for stakeholders to be representative of the relevant sectors and sub-sectors. The insights presented in this article should facilitate the implementation of this relatively simple, practical, and useful approach for understanding climate-related impacts, risks, vulnerabilities, and adaptation issues.
A multi-informant study of school climate: student, parent, and teacher perceptions
Authors: Molinari Luisa , Grazia Valentina
Published: November 2022

This paper presents a multi-informant study on school climate with the aim of (a) comparing students’, teachers’, and parents’ perceptions of several school climate dimensions and (b) examining the associations between dimensions pertaining to classroom practices and school atmosphere in both students and teachers. Participants comprised 105 teachers, 320 parents, and 1070 students (49% female; Mage = 11.77) enrolled in four middle schools in Northern Italy. The latent mean comparison of students’, teachers’, and parents’ perceptions revealed many significant differences, with teachers generally reporting better perceptions of the quality of the school environment. A multigroup path analysis highlighted associations between classroom practices and school atmosphere dimensions of school climate which varied for students and teachers. The findings are discussed in terms of their implications for school intervention and the fostering of a supportive school environment.
Heterogeneity in Behaviour and Movement can Influence the Stability of Predator–Prey Periodic Travelling Waves
Authors: Andrade Renato , Cobbold Christina A.
Published: November 2022

Cyclic predator–prey systems are often observed in nature. In a spatial setting, these can manifest as periodic traveling waves (PTW). Environmental change and direct human activity are known to, among other effects, increase the heterogeneity of the physical environment, which prey and predator inhabit. Aiming to understand the effects of heterogeneity on predator–prey PTWs, we consider a one-dimensional infinite landscape Rosenzweig–MacArthur reaction–diffusion model, with alternating patch types, and study the PTWs in this system. Applying the method of homogenisation, we show how heterogeneity can affect the stability of PTW solutions. We illustrate how the effects of heterogeneity can be understood and interpreted using Turchin’s concept of residence index (encapsuling diffusion rate and patch preference). In particular, our results show that prey heterogeneity acts to modulate the effects of predator heterogeneity, by this we mean that as prey increasingly spend more time in one patch type over another the stability of the PTWs becomes more sensitive to heterogeneity in predator movement and behaviour.
Simple solutions for complex problems? What is missing in agriculture for nutrition interventions
Authors: Hambloch Caroline , Mausch Kai , Conti Costanza , Hall Andy
Published: November 2022

Within the nutritionism paradigm, in this article we critically review the marketization and medicalization logics which aim to address the pressing issue of malnutrition in low- and middle-income countries. Drawing from political economy and food system transformation discourses, we are using the popular intervention types of nutrition-sensitive value chains (marketization logic) and biofortification exemplified through orange-fleshed sweet potato (medicalization logic) to assess their outcomes and underlying logics. We demonstrate that there is insufficient evidence of the positive impact of these interventions on nutritional outcomes, and that their underlying theories of change and impact logics do not deal with the inherent complexity of nutritional challenges. We show that nutrition-sensitive value chain approaches are unable to leverage or enhance the functioning of value chains to improve nutritional outcomes, especially in light of the disproportionate power of some food companies. We further demonstrate that orange-fleshed sweet potato interventions and biofortification more broadly adopt a narrow approach to malnutrition, disregarding the interactions between food components and broader value chain and food system dynamics. We argue that both intervention types focus solely on increasing the intake of specific nutrients without incorporating their embeddedness in the wider food systems and the relevant political-economic and social relations that influence the production and consumption of food. We conclude that the systemic nature of malnutrition requires to be understood and addressed as part of the food system transformation challenge in order to move towards solving it. To do so, new evaluation frameworks along with new approaches to solutions are necessary that support multiple and diverse development pathways, which are able to acknowledge the social, political-economic, and environmental factors and drivers of malnutrition and poverty.
Cost-effectiveness analysis of revisional Roux-en-Y gastric bypass: laparoscopic vs. robot assisted
Authors: Ugliono Elettra , Rebecchi Fabrizio , Vicentini Costanza , Salzano Antonio , Morino Mario
Published: November 2022

There is controversy over the possible advantages of the robotic technology in revisional bariatric surgery. The aim of this study is to report the experience of a high-volume bariatric center on revisional Roux-en-Y gastric bypass with robot-assisted (R-rRYGB) and laparoscopic (L-rRYGB) approaches, with regards to operative outcomes and costs. Patients who underwent R-rRYGB and L-rRYGB between 2008 and 2021 were included. Patients’ baseline characteristics and perioperative data were recorded. The primary endpoint was the overall postoperative morbidity. A full economic evaluation was performed. One-way and two-way sensitivity analyses were performed on laparoscopic anastomotic leak and reoperation rates. A total of 194 patients were included: 44 (22.7%) L-rRYGB and 150 (77.3%) R-rRYGB. The robotic approach was associated with lower overall complication rate (10% vs. 22.7%, p = 0.038), longer operative time, and a reduced length of stay compared to L-rRYGB. R-rRYGB was more expensive than L-rRYGB (mean difference 2401.1€, p < 0.001). The incremental cost-effective ratio (ICER) was 18,906.3€/complication and the incremental cost-utility ratio was 48,022.0€/QALY (quality-adjusted life years), that is below the willingness-to-pay threshold. Decision tree analysis showed that L-rRYGB was the most cost-effective strategy in the base-case scenario; a probability of leak ≥ 13%, or a probability of reoperation ≥ 14% following L-rRYGB, or a 12.7% reduction in robotic costs would be required for R-rRYGB to become the most cost-effective strategy. R-rRYGB was associated with higher costs than L-rRYGB in our base-case scenario. However, it is an acceptable alternative from a cost-effectiveness perspective.
The Unique and Practical Advantages of Applying A Capability Approach to Brain Computer Interface
Authors: Jecker Nancy S. , Ko Andrew
Published: November 2022

Intelligent neurotechnology is an emerging field that combines neurotechnologies like brain-computer interface (BCI) with artificial intelligence. This paper introduces a capability framework to assess the responsible use of intelligent BCI systems and provide practical ethical guidance. It proposes two tests, the threshold and flourishing tests, that BCI applications must meet, and illustrates them in a series of cases. After a brief introduction (Section 1), Section 2 sets forth the capability view and the two tests. It illustrates the threshold test using examples from clinical medicine of BCI applications that enable patients with profound disabilities to function at a threshold level through computer mediation. Section 3 illustrates the flourishing test by exploring possible future applications of BCI involving neuroenhancements for healthy people, using examples adapted from research currently underway in the US military. Section 3 applies a capability lens to a complex case involving dual effects, both therapeutic and non-therapeutic, showing how the threshold and flourishing tests resolve the case. Section 4 replies to three objections: neurorights are the best tool for assessing BCI; the two tests are moving targets; and the analysis utilizes a capability view to do work it is not designed for. The paper concludes that a capability view offers unique advantages and gives practical guidance for evaluating the responsible use of present and future BCI applications. Extrapolating from our analysis may help guide other emerging technologies, such as germline gene editing, expected to impact central human capabilities.
Understanding the impact of steam pretreatment severity on cellulose ultrastructure, recalcitrance, and hydrolyzability of Norway spruce
Authors: Caputo Fabio , Al-Rudainy Basel , Naidjonoka Polina , Wallberg Ola , Olsson Lisbeth , Novy Vera
Published: November 2022

The efficient use of softwood in biorefineries requires harsh pretreatment conditions to overcome biomass recalcitrance. Following harsh pretreatments, the hemicellulose is solubilized. Here, we studied the material characteristics of Norway spruce following steam pretreatment at six different severities, relating chemical and structural information to the enzymatic hydrolyzability. Steam pretreatment conditions were defined by two different temperatures (180 °C and 210 °C), with and without the addition of various acids (CH3COOH, H3PO4, H2SO4, SO2). Structural knowledge of the streams is a cornerstone for developing an efficient saccharification process.

This study combines advanced structural characterizations to gain fundamental understanding of the influence of severity of pretreatment on spruce. Structural knowledge is a cornerstone in developing an effective saccharification process by modulating pretreatment conditions and enzymes employed.

Overall structural properties were assessed by scanning electron microscopy. The effect of stream pretreatment severity on lignin and lignin-carbohydrate bonds was investigated by two-dimensional heteronuclear single quantum correlation nuclear magnetic resonance. Finally, cellulose ultrastructure was studied by applying small/wide-angle X-ray scattering. The structural characteristics of the six pretreated softwood substrates were related to the enzymatic hydrolyzability.

With increasing pretreatment severity, surface defibrillation, and lignin depolymeryzation were observed. Further, lignin-carbohydrate complexes signals were detected. Cellulose analysis revealed the rearrangement of microfibrils leading to the formation of larger microfibril aggregates. This microfibril rearrangement likely contributed to the observed increase in enzymatic hydrolysis yields as better enzyme accessibility resulted.
Real-world evidence for steroidal mineralocorticoid receptor antagonists in patients with chronic kidney disease
Authors: Folkerts Kerstin , Millier Aurelie , Smela Beata , Olewinska Elzbieta , Schmedt Niklas , Mernagh Paul , Kovesdy Csaba P.
Published: November 2022

Background

Mineralocorticoid receptor antagonists (MRAs) were shown to delay chronic kidney disease (CKD) progression in patients with hypertension and/or heart failure (HF) and proteinuria.

Objective

We conducted a systematic literature review on real-world evidence to identify the literature gaps related to the efficacy and safety outcomes of MRAs administered to CKD patients.

Results

A total of 751 records were identified of which, 23 studies (26 publications) were analyzed. Studies included heterogeneous populations, including the overall CKD, CKD and diabetes, CKD and HF, and CKD and a history of cardiovascular disease. Most of the studies were small and non-rigorous, resulting in a notable lack of evidence in these populations. In the overall CKD population, steroidal MRAs resulted in a significant or sustained eGFR reduction but no efficacy in delaying progression to end-stage kidney disease. No cardiovascular protection was found. Results for all-cause mortality and hospitalization for HF were inconsistent; however, the longest follow-up studies indicate similar or lower incidence for spironolactone non-users. Most results consistently reported a higher incidence of hyperkalemia among patients on steroidal MRAs in all CKD stages, and side effects led to high discontinuation rates in the real-world setting.

Conclusions

Despite the limited availability of evidence on the effectiveness and safety of steroidal MRAs in CKD patients and subgroups with diabetes, HF or history of cardiovascular disease, MRAs were shown to have a limited effect on renal and cardiovascular outcomes. Gaps in the evidence regarding the efficacy and safety of MRAs are particularly relevant in diabetic CKD patients; therefore, further research is warranted.
Clinical features suggesting renal hypouricemia as the cause of acute kidney injury: a case report and review of the literature
Authors: Mazzierli Tommaso , Cirillo Luigi , Palazzo Viviana , Ravaglia Fiammetta , Becherucci Francesca
Published: November 2022

Hypouricemia is defined as a level of serum uric acid below 2 mg/dl. Renal hypouricemia is related to genetic defects of the uric acid tubular transporters urate transporter 1 and glucose transporter 9. Patients with renal hypouricemia can be completely asymptomatic or can develop uric acid kidney stones or acute kidney injury, particularly after exercise. Renal hypouricemia is especially challenging to diagnose in patients with acute kidney injury, due to the nonspecific clinical, hematochemical and histological features. No common features are reported in the literature that could help clinicians identify renal hypouricemia-acute kidney injury. Currently available guidelines on diagnosis and management of renal hypouricemia provide limited support in defining clues for the differential diagnosis of renal hypouricemia, which is usually suspected when hypouricemia is found in asymptomatic patients. In this paper we report a case of renal hypouricemia-acute kidney injury developing after exercise. We carried out a review of the literature spanning from the first clinical description of renal hypouricemia in 1974 until 2022. We selected a series of clinical features suggesting a diagnosis of renal hypouricemia-acute kidney injury. This may help clinicians to suspect renal hypouricemia in patients with acute kidney injury and to avoid invasive, costly and inconclusive exams such as renal biopsy. Considering the excellent outcome of the patients reported in the literature, we suggest a “wait-and-see” approach with supportive therapy and confirmation of the disease via genetic testing.
Confusion in the West
Authors: Rist Anna , Rist John
Published: November 2022

In their trenchant panoramic overview – ranging from antiquity to the present-day – John and Anna Rist write with authority and ennui about nothing less than the loss of the foundational culture of the West. The authors characterize this culture as the 'original tradition', viewing its erosion as one which has led to anxiety about the entire value of Western thought. The causes of the disintegration are discussed with an intensity rare in academe. Critics of modernity ordinarily concentrate on the Enlightenment and the book certainly offers deep analysis of Enlightenment thought. But it goes further. Thus the cruelty of modern totalitarianism is now depicted as in the spirit of the French Revolution and its implacable hostility to a vanished primordial heritage, while scientism, bureaucracy and consumerism appear as the only rivals to a threatening nihilism. The book argues that Western thought has created a set of conflicting moral and spiritual customs: to the detriment of coherence, in individual minds as in society and culture.
The Crusades Uncovered
Authors: Boas Adrian J.
Published: November 2022

Adrian J. Boas, an archaeologist with four decades' experience in the field, takes a fresh approach to investigating the experiences of crusaders, pilgrims, and settlers in the crusader states during the twelfth and thirteenth centuries. The book opens up the experience of medieval travel and crusading by drawing on personal reflection and comparison with contemporary events. Topics covered include wonderment at the strangeness of the East, adjusting to life in the Levant, the horrors of warfare, the drama of fortress and battlefield, and the theatrical beauty of religious architecture, together with new perceptions of a selection of characters known and less-known. The book encourages the reader to think more deeply as to the meaning of the topics involved.
American Mass Incarceration and Post-Network Quality Television
Authors: Flamand Lee
Published: November 2022

Far more than a building of brick and mortar, the prison relies upon gruesome stories circulated as commercial media to legitimize its institutional reproduction. Perhaps no medium has done more in recent years to both produce and intervene in such stories than television.

This unapologetically interdisciplinary work presents a series of investigations into some of the most influential and innovative treatments of American mass incarceration to hit our screens in recent decades. Looking beyond celebratory accolades, Lee A. Flamand argues that we cannot understand the eagerness of influential programs such as OZ, The Wire, Orange Is the New Black, 13th, and Queen Sugar to integrate the sensibilities of prison ethnography, urban sociology, identity politics activism, and even Black feminist theory into their narrative structures without understanding how such critical postures relate to the cultural aspirations and commercial goals of a quickly evolving TV industry and the most deeply ingrained continuities of American storytelling practices.
Scripting Justice in Late Medieval Europe
Authors: Camphuijsen Frans
Published: November 2022

Late medieval societies witnessed the emergence of a particular form of socio-legal practice and logic, focused on the law court and its legal process. In a context of legal pluralism, courts tried to carve out their own position by influencing people's conception of what justice was and how one was supposed to achieve it. These 'scripts of justice' took shape through a range of media, including texts, speech, embodied activities and the spaces used to perform all these. Looking beyond traditional historiographical narratives of state building or the professionalization of law, this book argues that the development of law courts was grounded in changing forms of multimedial interaction between those who sought justice and those who claimed to provide it. Through a comparative study of three markedly different types of courts, it involves both local contexts and broader developments in tracing the communication strategies of these late medieval claimants to socio-legal authority.
United Nations Disability Inclusion Strategy: A framework to accelerate transformative change for persons with disabilities in the peace and security pillar
Authors: Mitra Gopal , Dominik Georgia
Published: November 2022

The United Nations Disability Inclusion Strategy establishes the first-ever framework for the United Nations system to advance disability inclusion across all pillars of the Organization's work, including the peace and security pillar, and to measure the progress made across the system. Evidence reported since the launch of the Strategy in 2019 demonstrates that the Strategy has provided a clear impetus among United Nations entities and peace operations working in the sector to address the rights of persons with disabilities, who are among the most marginalized in any crisis-affected community. However, the evidence also reveals that while humanitarian entities have made progress since the launch of the Strategy, disability inclusion remains an emerging area of work for peace operations in the field. The article argues that the Strategy's accountability framework has provided a much-needed blueprint and ability to monitor progress across the system, yet far more needs to be done to ensure that the United Nations system is equipped to respond to complex situations and reach the furthest behind first.
Dissolved, Labile, and Total Particulate Trace Metal Dynamics on the Northeast Greenland Shelf
Authors: Chen Xue‐Gang , Krisch Stephan , Al‐Hashem Ali , Hopwood Mark James , Rutgers van der Loeff Michiel M. , Huhn Oliver , Lodeiro Pablo , Steffens Tim , Achterberg Eric P.
Published: November 2022

We present high‐resolution profiles of dissolved, labile, and total particulate trace metals (TMs) on the Northeast Greenland shelf from GEOTRACES cruise GN05 in August 2016. Combined with radium isotopes, stable oxygen isotopes, and noble gas measurements, elemental distributions suggest that TM dynamics were mainly regulated by the mixing between North Atlantic‐derived Intermediate Water, enriched in labile particulate TMs (LpTMs), and Arctic surface waters, enriched in Siberian shelf‐derived dissolved TMs (dTMs; Co, Cu, Fe, Mn, and Ni) carried by the Transpolar Drift. These two distinct sources were delineated by salinity‐dependent variations of dTM and LpTM concentrations and the proportion of dTMs relative to the total dissolved and labile particulate ratios. Locally produced meltwater from the Nioghalvfjerdsbræ (79NG) glacier cavity, distinguished from other freshwater sources using helium excess, contributed a large pool of dTMs to the shelf inventory. Localized peaks in labile and total particulate Cd, Co, Fe, Mn, Ni, Cu, Al, V, and Ti in the cavity outflow, however, were not directly contributed by submarine melting. Instead, these particulate TMs were mainly supplied by the re‐suspension of cavity sediment particles. Currently, Arctic Ocean outflows are the most important source of dFe, dCu, and dNi on the shelf, while LpTMs and up to 60% of dMn and dCo are mainly supplied by subglacial discharge from the 79NG cavity. Therefore, changes in the cavity‐overturning dynamics of 79NG induced by glacial retreat, and alterations in the transport of Siberian shelf‐derived materials with the Transport Drift may shift the shelf dTM‐LpTM stoichiometry in the future.
Imaging the Northeastern Crustal Boundary of the Tibetan Plateau With Radial Anisotropy
Authors: Li Shilin , Guo Zhen , Yu Yong , Wu Xiaoyang , Chen Yongshun John
Published: November 2022

We obtained a 3‐D crustal radial anisotropy model beneath northeastern (NE) Tibet by joint inversion of Rayleigh and Love dispersion curves from ambient noise tomography. Positive crustal radial anisotropy and significant low velocity are dominant beneath the Songpan‐Ganzi Terrane (SGT), indicating the presence of crustal channel flow. The Qilian orogen is characterized by negative radial anisotropy, which could be caused by folding and thrusting due to crustal shortening. This difference in radial anisotropy suggests that crustal shortening deformation may have occurred at a relatively early stage of the plateau evolution (the Qilian orogen) and crustal channel flow at the later stage (the SGT). The crustal radial anisotropy clearly defines the NE crustal boundary of the expanding Tibetan Plateau, which is roughly situated along the north Qilian frontal thrust from 97° to 103.5°E in the north and turns north‐south, passing the Zhuanglanghe Fault and terminating at the Kunlun Fault in the south.
Flow Channels and the Generation of Alfvénic Turbulence Along Storm‐Time Inner Magnetospheric Field‐Lines
Authors: Chaston Christopher C.
Published: November 2022

A feature of Earth's storm‐time magnetosphere outside the plasmapause is the occurrence of broad‐spectrum Alfvénic fluctuations. In this letter observations from the Van Allen Probes are compared with 3‐D fluid‐kinetic simulations of an evolving convective flow channel to investigate the mechanisms generating the observed spectrum. It is shown how narrow channels of fast convection are unstable to the Kelvin‐Helmholtz instability which on closed field‐lines initiates a cascade to small scales. Sustained driving of the flow combined with reflection from the topside ionosphere leads to the generation of an intensified spectrum of electromagnetic structures having similar spectral and morphological characteristics to those observed. This process couples enhanced magnetospheric convection to kinetic scale electromagnetic fluctuations that drive particle transport, scattering and energization through the outer radiation belt and ring current during geomagnetic storms.
Going Local: How Coastal Environmental Settings Can Help Improve Global Mangrove Carbon Storage and Flux Estimates
Authors: Taillardat Pierre
Published: November 2022

The magnitude and variability of mangrove carbon storage are uncertain and still being discussed. In a recent article, Breithaupt and Steinmuller (2022, https://doi.org/10.1029/2022GL100177) completed a literature review and compared mangrove organic carbon burial rates between different coastal environmental settings (CES) that integrate sedimentary supply (terrigenous vs. carbonate) and hydrogeomorphic settings (delta, estuary, lagoon, open coast). They found greater burial rates in terrigenous delta and estuaries while lower rates were reported in lagoons and carbonate settings. Surprisingly, these CES relationships do not strictly match previous mangrove soil carbon stock estimates but were consistent with biomass stocks. The CES approach used by Breithaupt and Steinmuller should be used for other mangrove carbon stocks and fluxes estimates to refine our understanding of mangrove carbon cycling and storage.
Survey of Electron Heating and Implications for Wave‐Particle Interactions Near the Lunar Surface: ARTEMIS Observations
Authors: Sawyer R. P. , Halekas J. S.
Published: November 2022

Interactions between the incident solar wind plasma and lunar crustal magnetic fields can lead to modifications in electron and ion dynamics that can result in the generation of electrostatic and electromagnetic waves. The resulting waves can then interact with the ambient electrons, leading to perpendicular and/or parallel electron heating. We analyze 10 years of data from the Acceleration, Reconnection, Turbulence, and Electrodynamics of Moon's Interaction with the Sun mission, when the spacecraft was within 200 km of the dayside lunar surface and within the solar wind, in order to characterize the near‐Moon plasma environment. We find that as the reflected ion density increases, electrostatic waves associated with plasma conditions favorable for the electron cyclotron drift instability play an increasingly important role in perpendicular electron heating, while electromagnetic interactions display the opposite trend. Additionally, we find that electrostatic waves associated with parallel heating exhibit plasma characteristics that are consistent with both the electron two‐stream instability and the modified two‐stream instability.
Protective effect of hepatocyte-enriched lncRNA-Mir122hg by promoting hepatocyte proliferation in acute liver injury
Authors: Yu Zhenjun , Li Yuhan , Shao Shuai , Guo Beichen , Zhang Mengxia , Zheng Lina , Zhang Kun , Zhou Feng , Zhang Li , Chen Chiyi , Jiang Wentao , Hong Wei , Han Tao
Published: November 2022

Some long noncoding RNAs (lncRNAs), which harbor microRNAs in their gene sequence and are also known as microRNA host gene derived lncRNAs (lnc-MIRHGs), play a dominant role alongside miRNAs, or both perform biological functions synergistically or independently. However, only a small number of lnc-MIRHGs have been identified. Here, multiple liver injury datasets were analyzed to screen and identify the target lncRNA Mir122hg. Mir122hg was mainly enriched in liver tissues with human-mouse homology. In both CCl4-induced acute liver injury and Dgal/LPS-induced fulminant liver failure in mice, Mir122hg was sharply downregulated at the early stage, while a subsequent significant increase was only found in the CCl4 group with liver recovery. Overexpression and silencing assays confirmed that Mir122hg played a protective role in acute injury by promoting hepatocyte proliferation in vivo and in vitro. Consistent with the results of gene enrichment analysis, Mir122hg binding to C/EBPα affected its transcriptional repression, promoted gene transcription of downstream chemokines, Cxcl2, Cxcl3, and Cxcl5, and exerted pro-proliferative effects on hepatocytes through activation of the AKT/GSK-3β/p27 signaling pathway by CXC/CXCR2 complexes. This study identifies a novel lncRNA with protective effects in acute liver injury and demonstrates that the binding of Mir122hg-C/EBPα promotes hepatocyte proliferation via upregulation of CXC chemokine and activation of AKT signaling.
HDAC1/3-dependent moderate liquid–liquid phase separation of YY1 promotes METTL3 expression and AML cell proliferation
Authors: Li Meng , Li Mingying , Xia Yuan , Li Guosheng , Su Xiuhua , Wang Dongmei , Ye Jingjing , Lu Fei , Sun Tao , Ji Chunyan
Published: November 2022

Methyltransferase-like protein 3 (METTL3) plays critical roles in acute myeloid leukemia (AML) progression, however, the mechanism of abnormal overexpression of METTL3 in AML remain elusive. In the current study, we uncovered that Yin Yang 1 (YY1) binds to the promoter region of METTL3 as a transcription factor and promotes its expression, which in turn enhances the proliferation of AML cells. Mechanistically, YY1 binds to HDAC1/3 and regulates METTL3 expression in a moderate liquid-liquid phase separation (LLPS) manner. After mutation of the HDAC-binding site of YY1 or HDAC inhibitor (HDACi) treatment, YY1 was separated from HDAC1/3, which resulted in an excessive LLPS state, thereby inhibiting the expression of METTL3 and the proliferation of AML cells. In conclusion, our study clarified the regulatory mechanism of the abnormal expression of METTL3 in AML, revealed the precise “Yin-Yang” regulatory mechanism of YY1 from the perspective of LLPS degree, and provided new ideas for the precise diagnosis and treatment of AML.
Kinetics of mRNA nuclear export regulate innate immune response gene expression
Authors: Lefaudeux Diane , Sen Supriya , Jiang Kevin , Hoffmann Alexander ,   the UCLA Ribonomics Group, Sanchez Arriola Jose Guillermo , Miller Nick , Cheng Zhang , Chen Emily Yi Hsin , Roy Sukanya , Spreafico Roberto , Johnson Tracy L. , Wissink Erin M. , Ghosh Shubhamoy , Black Douglas L. , Lin Chia-Ho , Xiao Xinshu , Bahn Jae Hoon , Cass Ashley A. , Hsiao Esther Y. H. , Smale Stephen T. , Lo Jerry Hung-Hao , Ernst Jason , Jaroszewicz Artur , Pellegrini Matteo , Morselli Marco , Xing Yi , Park Eddie , Kosuri Sri
Published: November 2022

The abundance and stimulus-responsiveness of mature mRNA is thought to be determined by nuclear synthesis, processing, and cytoplasmic decay. However, the rate and efficiency of moving mRNA to the cytoplasm almost certainly contributes, but has rarely been measured. Here, we investigated mRNA export rates for innate immune genes. We generated high spatio-temporal resolution RNA-seq data from endotoxin-stimulated macrophages and parameterized a mathematical model to infer kinetic parameters with confidence intervals. We find that the effective chromatin-to-cytoplasm export rate is gene-specific, varying 100-fold: for some genes, less than 5% of synthesized transcripts arrive in the cytoplasm as mature mRNAs, while others show high export efficiency. Interestingly, effective export rates do not determine temporal gene responsiveness, but complement the wide range of mRNA decay rates; this ensures similar abundances of short- and long-lived mRNAs, which form successive innate immune response expression waves.
Quantum transport evidence of isolated topological nodal-line fermions
Authors: Kim Hoil , Ok Jong Mok , Cha Seyeong , Jang Bo Gyu , Kwon Chang Il , Kohama Yoshimitsu , Kindo Koichi , Cho Won Joon , Choi Eun Sang , Jo Youn Jung , Kang Woun , Shim Ji Hoon , Kim Keun Su , Kim Jun Sung
Published: November 2022

Anomalous transport responses, dictated by the nontrivial band topology, are the key for application of topological materials to advanced electronics and spintronics. One promising platform is topological nodal-line semimetals due to their rich topology and exotic physical properties. However, their transport signatures have often been masked by the complexity in band crossings or the coexisting topologically trivial states. Here we show that, in slightly hole-doped SrAs3, the single-loop nodal-line states are well-isolated from the trivial states and entirely determine the transport responses. The characteristic torus-shaped Fermi surface and the associated encircling Berry flux of nodal-line fermions are clearly manifested by quantum oscillations of the magnetotransport properties and the quantum interference effect resulting in the two-dimensional behaviors of weak antilocalization. These unique quantum transport signatures make the isolated nodal-line fermions in SrAs3 desirable for novel devices based on their topological charge and spin transport.
Spatially aware dimension reduction for spatial transcriptomics
Authors: Shang Lulu , Zhou Xiang
Published: November 2022

Spatial transcriptomics are a collection of genomic technologies that have enabled transcriptomic profiling on tissues with spatial localization information. Analyzing spatial transcriptomic data is computationally challenging, as the data collected from various spatial transcriptomic technologies are often noisy and display substantial spatial correlation across tissue locations. Here, we develop a spatially-aware dimension reduction method, SpatialPCA, that can extract a low dimensional representation of the spatial transcriptomics data with biological signal and preserved spatial correlation structure, thus unlocking many existing computational tools previously developed in single-cell RNAseq studies for tailored analysis of spatial transcriptomics. We illustrate the benefits of SpatialPCA for spatial domain detection and explores its utility for trajectory inference on the tissue and for high-resolution spatial map construction. In the real data applications, SpatialPCA identifies key molecular and immunological signatures in a detected tumor surrounding microenvironment, including a tertiary lymphoid structure that shapes the gradual transcriptomic transition during tumorigenesis and metastasis. In addition, SpatialPCA detects the past neuronal developmental history that underlies the current transcriptomic landscape across tissue locations in the cortex.