bluuebunny/crossref_metadata_2025 huggingface dataset:
Magnetically Guided Microcatheter for Targeted Injection of Magnetic Particle Swarms
Authors: Torlakcik Harun , Sevim Semih , Alves Pedro , Mattmann Michael , Llacer‐Wintle Joaquim , Pinto Maria , Moreira Rosa , Flouris Andreas D. , Landers Fabian C. , Chen Xiang‐Zhong , Puigmartí‐Luis Josep , Boehler Quentin , Mayor Tiago Sotto , Kim Minsoo , Nelson Bradley J. , Pané Salvador
Published: August 2024

The initial delivery of small‐scale magnetic devices such as microrobots is a key, but often overlooked, aspect for their use in clinical applications. The deployment of these devices within the dynamic environment of the human body presents significant challenges due to their dispersion caused by circulatory flows. Here, a method is introduced to effectively deliver a swarm of magnetic nanoparticles in fluidic flows. This approach integrates a magnetically navigated robotic microcatheter equipped with a reservoir for storing the magnetic nanoparticles. The microfluidic flow within the reservoir facilitates the injection of magnetic nanoparticles into the fluid stream, and a magnetic field gradient guides the swarm through the oscillatory flow to a target site. The microcatheter and reservoir are engineered to enable magnetic steering and injection of the magnetic nanoparticles. To demonstrate this approach, experiments are conducted utilizing a spinal cord phantom simulating intrathecal catheter delivery for applications in the central nervous system. These results demonstrate that the proposed microcatheter successfully concentrates nanoparticles near the desired location through the precise manipulation of magnetic field gradients, offering a promising solution for the controlled deployment of untethered magnetic micro‐/nanodevices within the complex physiological circulatory systems of the human body.
Mechanocatalytic Hydrogen Generation in Centrosymmetric Barium Dititanate
Authors: Du Yumeng , Sun Wei , Li Xiaoning , Hao Chongyan , Wang Jianli , Fan Yameng , Joseph Jincymol , Yang Changhong , Gu Qinfen , Liu Yun , Zhang Shujun , Cheng Zhenxiang
Published: August 2024

Novel phase of nano materials that break the traditional structural constraints are highly desirable, particularly in the field of mechanocatalysis, offering versatile applications ranging from energy to medical diagnosis and treatment. In this work, a distinct layered barium dititanate (BaTi2O5) nanocrystals using a pH‐modulated hydrothermal method is successfully synthesized. These nanocrystals exhibit outstanding hydrogen generation capability (1160 µmol g−1 h−1 in pure water) and demonstrate remarkable performance in organic dye degradation using ultrasonication. The crystal structure of this newly discovered BaTi2O5 phase, is determined by a combination of synchrotron Powder Diffraction refinement and X‐ray adsorption techniques, including X‐ray Absorption Near Edge Structure (XANES) and Extended X‐ray Absorption Fine Structure (EXAFS). Density Functional Theory calculations revealed that the newly‐discovered BaTi2O5 phase demonstrates dipole moments along the z‐axis, distributed in an antiparallel direction within a single unit cell. These inherent dipoles induce a surface polarization and a ferroelectric‐flexoelectric response under mechanical stimuli when the materials go to nano dimension. With a band alignment well‐suitable for hydrogen and reactive oxygen species generation, this BaTi2O5 phase demonstrates promising potential for Mechanocatalysis. The discovery of this distinct phase not only enriches the material candidates for mechanocatalysis but also provides valuable insights.
Diethylenetriaminepentaacetic Acid‐based Conducting Solid Polymer Electrolytes Impede Lithium Dendrites and Impart Antioxidant Capacity in Lithium‐Ion Batteries
Authors: Zang Yuli , Irfan Muhammad , Yang Zeheng , Zhang Weixin
Published: August 2024

In the development of lithium‐ion batteries (LIBs), cheaper and safer solid polymer electrolytes are expected to replace combustible organic liquid electrolytes to meet the larger market demand. However, low ionic conductivity and inadequate cycling stability impede their commercial viability. Herein, a novel flexible conducting solid polymer electrolytes (CSPEs) based on polyvinyl alcohol (PVA) and ion‐polarized diethylenetriaminepentaacetic acid (P‐DETP) is developed for the first time and applied in LIBs. PVA and P‐DETP form a compact polymer network through hydrogen bonding, enhancing the thermomechanical stability of CSPE while restricting the migration of larger anions. Furthermore, density functional theory calculations confirm that P‐DETP can facilitate the dissociation of Li+‐TFSI‐ via electrostatic attraction, resulting in increased mobility of lithium ions. Additionally, P‐DETP contributes to the formation of a stable electrode‐electrolyte interface layer, effectively suppressing the growth of lithium dendrites and improving antioxidant capacity. These synergistic effects enable CSPE to exhibit remarkable properties including high ionic conductivity (2.8 × 10−4 S cm−1), elevated electrochemical potential (5.1 V), and excellent lithium transference number (0.869). Notably, the P‐DETP/LiTFSI CSPE demonstrates stable performance not only in LiFePO4 batteries but also adapts to high‐nickel ternary LiNi0.88Co0.06Mn0.06O2 cathode, highlighting its immense potential for application in high energy density LIBs.
Band Structure Engineering in 2D Metal–Organic Frameworks
Authors: Mearini Simone , Baranowski Daniel , Brandstetter Dominik , Windischbacher Andreas , Cojocariu Iulia , Gargiani Pierluigi , Valvidares Manuel , Schio Luca , Floreano Luca , Puschnig Peter , Feyer Vitaliy , Schneider Claus Michael
Published: August 2024

The design of 2D metal–organic frameworks (2D MOFs) takes advantage of the combination of the diverse electronic properties of simple organic ligands with different transition metal (TM) centers. The strong directional nature of the coordinative bonds is the basis for the structural stability and the periodic arrangement of the TM cores in these architectures. Here, direct and clear evidence that 2D MOFs exhibit intriguing energy‐dispersive electronic bands with a hybrid character and distinct magnetic properties in the metal cores, resulting from the interactions between the TM electronic levels and the organic ligand π‐molecular orbitals, is reported. Importantly, a method to effectively tune both the electronic structure of 2D MOFs and the magnetic properties of the metal cores by exploiting the electronic structure of distinct TMs is presented. Consequently, the ionization potential characteristic of selected TMs, particularly the relative energy position and symmetry of the 3d states, can be used to strategically engineer bands within specific metal–organic frameworks. These findings not only provide a rationale for band structure engineering in 2D MOFs but also offer promising opportunities for advanced material design.
3D‐Printed Hydrogel‐Based Flexible Electrochromic Device for Wearable Displays
Authors: Luo Xiaoyu , Wan Rongtai , Zhang Zhaoxian , Song Manting , Yan Lixia , Xu Jingkun , Yang Hanjun , Lu Baoyang
Published: August 2024

Flexible electrochromic devices (FECDs) are widely explored for diverse applications including wearable electronics, camouflage, and smart windows. However, the manufacturing process of patterned FECDs remains complex, costly, and non‐customizable. To address this challenge, a strategy is proposed to prepare integrated FECDs via multi‐material direct writing 3D printing. By designing novel viologen/polyvinyl alcohol (PVA) hydrogel inks and systematically evaluating the printability of various inks, seamless interface integration can be achieved, enabling streamlined manufacturing of patterned FECDs with continuous production capabilities. The resultant 3D‐printed FECDs exhibit excellent electrochromic and mechanical properties, including high optical contrast (up to 54% at 360 nm), nice cycling stability (less than 5% electroactivity reduction after 10 000 s), and mechanical stability (less than 19% optimal contrast decrease after 5000 cycles of bending). The potential applications of these 3D‐printed hydrogel‐based FECDs are further demonstrated in wearable electronics, camouflage, and smart windows.
General Post‐Regulation Strategy of AIEgens’ Photophysical Properties for Intravital Two‐Photon Fluorescence Imaging
Authors: Lin Liyun , Liu Jiaxin , Pan Zhengyuan , Pang Wen , Jiang Xinyan , Lei Man , Gao Jucai , Xiao Yujie , Li Bo , Hu Fang , Bao Zhouzhou , Wei Xunbin , Wu Wenbo , Gu Bobo
Published: August 2024

Fluorogens with aggregation‐induced emission (AIEgens) are promising agents for two‐photon fluorescence (TPF) imaging. However, AIEgens’ photophysical properties are fixed and unoptimizable once synthesized. Therefore, it is urgent and meaningful to explore an efficient post‐regulation strategy to optimize AIEgens’ photophysical properties. Herein, a general and efficient post‐regulation strategy is reported. By simply tuning the ratio of inert AIEgens within binary nanoparticles (BNPs), the fluorescence quantum yield and two‐photon absorption cross‐section of functional AIEgens are enhanced by 8.7 and 5.4 times respectively, which are not achievable by conventional strategies, and the notorious phototoxicity is almost eliminated. The experimental results, theoretical simulation, and mechanism analysis demonstrated its feasibility and generality. The BNPs enabled deep cerebrovascular network imaging with ≈1.10 mm depth and metastatic cancer cell detection with single‐cell resolution. Furthermore, the TPF imaging quality is improved by the self‐supervised denoising algorithm. The proposed binary molecular post‐regulation strategy opened a new avenue to efficiently boost the AIEgens’ photophysical properties and consequently TPF imaging quality.
Wet‐Spinning Carbon Nanotube/Shape Memory Polymer Composite Fibers with High Actuation Stress and Predesigned Shape Change
Authors: Li Meng , Chen Kun , Zhang Ding , Ye Ziming , Yang Zifan , Wang Qi , Jiang Zhifan , Zhang Yingjiu , Shang Yuanyuan , Cao Anyuan
Published: August 2024

Actuators based on shape memory polymers and composites incorporating nanomaterial additives have been extensively studied; achieving both high output stress and precise shape change by low‐cost, scalable methods is a long‐term‐desired yet challenging task. Here, conventional polymers (polyurea) and carbon nanotube (CNT) fillers are combined to fabricate reinforced composite fibers with exceptional actuation performance, by a wet‐spinning method amenable for continuous production. It is found that a thermal‐induced shrinkage step could obtain densified strong fibers, and the presence of CNTs effectively promotes the tensile orientation of polymer molecular chains, leading to much improved mechanical properties. Consequently, the CNT/ polyurea composite fibers exhibit stresses as high as 33 MPa within 0.36 s during thermal actuation, and stresses up to 22 MPa upon electrical stimulation enabled by the built‐in conductive CNT networks. Utilizing the flexible thin fibers, various shape change behavior are also demonstrated including the conversion between different structures/curvatures, and recovery of predefined simple patterns. This high‐performance composite fibers, capable of both thermal and electrical actuation and produced by low‐cost materials and fabrication process, may find many potential applications in wearable devices, robotics, and biomedical areas.
Recent Advances in Transparent Electrodes and Their Multimodal Sensing Applications
Authors: Althumayri Majed , Das Ritu , Banavath Ramu , Beker Levent , Achim Alin M. , Ceylan Koydemir Hatice
Published: August 2024

This review examines the recent advancements in transparent electrodes and their crucial role in multimodal sensing technologies. Transparent electrodes, notable for their optical transparency and electrical conductivity, are revolutionizing sensors by enabling the simultaneous detection of diverse physical, chemical, and biological signals. Materials like graphene, carbon nanotubes, and conductive polymers, which offer a balance between optical transparency, electrical conductivity, and mechanical flexibility, are at the forefront of this development. These electrodes are integral in various applications, from healthcare to solar cell technologies, enhancing sensor performance in complex environments. The paper addresses challenges in applying these electrodes, such as the need for mechanical flexibility, high optoelectronic performance, and biocompatibility. It explores new materials and innovative techniques to overcome these hurdles, aiming to broaden the capabilities of multimodal sensing devices. The review provides a comparative analysis of different transparent electrode materials, discussing their applications and the ongoing development of novel electrode systems for multimodal sensing. This exploration offers insights into future advancements in transparent electrodes, highlighting their transformative potential in bioelectronics and multimodal sensing technologies.
Biomimetic Hydrodynamic Sensor with Whisker Array Architecture and Multidirectional Perception Ability
Authors: Dai Huangzhe , Zhang Chengqian , Hu Hao , Hu Zhezai , Sun Haonan , Liu Kan , Li Tiefeng , Fu Jianzhong , Zhao Peng , Yang Huayong
Published: August 2024

The rapid development of ocean exploration and underwater robot technology has put forward new requirements for underwater sensing methods, which can be used for hydrodynamic characteristics perception, underwater target tracking, and even underwater cluster communication. Here, inspired by the specialized undulated surface structure of the seal whisker and its ability to suppress vortex‐induced vibration, a multidirectional hydrodynamic sensor based on biomimetic whisker array structure and magnetic 3D self‐decoupling theory is introduced. The magnetic‐based sensing method enables wireless connectivity between the magnetic functional structures and electronics, simplifying device design and endowing complete watertightness. The 3D self‐decoupling capability enables the sensor, like a seal or other organisms, to perceive arbitrary whisker motions caused by the action of water flow without complex calibration and additional sensing units. The whisker sensor is capable of detecting a variety of hydrodynamic information, including the velocity (RMSE < 0.061 m s−1) and direction of the steady flow field, the frequency (error < 0.05 Hz) of the dynamic vortex wake, and the orientation (error < 7°) of the vortex wake source, demonstrating its extensive potential for underwater environmental perception and communication, especially in deep sea conditions.
Synthesis of Branched α‐Olefins via Trimerization and Tetramerization of Ethylene
Authors: Lukas Fabian , Simon Paula A. , Dietel Thomas , Kretschmer Winfried P. , Kempe Rhett
Published: August 2024

α‐Olefins are very important bulk and fine chemicals and their synthesis from ethylene, an abundantly available and inexpensive feedstock, is highly attractive. Unfortunately, the direct or on‐purpose synthesis of olefins from ethylene is limited to three examples, 1‐butene, 1‐hexene, and 1‐octene, all having a linear structure. Herein, the direct synthesis of 3‐methylenepentane and 4‐ethylhex‐1‐ene, branched trimerization, and tetramerization products of ethylene, respectively, is reported. Different molecular titanium catalysts, all highly active, with a selectivity toward the formation of the branched ethylene trimer or tetramer, the employment of different activators, and different reaction conditions are the key to selective product formation. The long‐time stability of selected catalysts employed permits upscaling as demonstrated for the synthesis of 4‐ethylhex‐1‐ene (52 g isolated, TON(ethylene) 10.7 · 106).
Atroposelective Synthesis of Biaryl N‐Oxides via Cu‐Catalyzed De Novo Heteroaromatic N‐Oxide Ring Formation
Authors: Ma Ke , Qi Ting , Hu Lei , Chen Chen , Wang Wan , Li Jun‐Long , Peng Cheng , Zhan Gu , Han Bo
Published: August 2024

Heteroaromatic N‐oxides, renowned for their highly polar N─O bond and robust structure, exhibit significant bioactivities and have played a pivotal role in various drug development projects since the discovery of Minoxidil. Moreover, heteroaromatic N‐oxides, featuring axially chiral biaryl frameworks, are indispensable as Lewis base catalysts and ligands in organic synthesis. Despite their importance, synthesizing these chiral compounds is challenging, necessitating chiral starting materials or resolution processes. Catalytic strategies rely on the functionalization of heteroaromatic N‐oxide compounds, leading to products with a relatively limited skeletal diversity. This study introduces a Cu‐catalyzed atroposelective method for synthesizing biaryl N‐oxides via de novo heteroaromatic N‐oxide ring formation. This mild and efficient approach achieves excellent stereoselectivities (up to 99:1 er), enabling the production of a wide array of N‐oxides with novel heteroaromatic scaffolds. The axially chiral N‐oxide product 3f demonstrates high stereoselectivity and recyclability as a Lewis base catalyst. Additionally, product 3e exhibits promising therapeutic efficacy against triple‐negative breast cancer, with IC50 values of 4.8 and 5.2 µm in MDA‐MB‐231 and MDA‐MB‐468 cells, respectively. This research not only advances the synthesis of challenging chiral heteroaromatic N‐oxides but also encourages further exploration of N‐oxide entities in the discovery of bioactive small molecules.
Discovery of PRMT3 Degrader for the Treatment of Acute Leukemia
Authors: Zou Wanyi , Li Mengna , Wan Shili , Ma Jingkun , Lian Linan , Luo Guanghao , Zhou Yubo , Li Jia , Zhou Bing
Published: August 2024

Protein arginine methyltransferase 3 (PRMT3) plays an important role in gene regulation and a variety of cellular functions, thus, being a long sought‐after therapeutic target for human cancers. Although a few PRMT3 inhibitors are developed to prevent the catalytic activity of PRMT3, there is little success in removing the cellular levels of PRMT3‐deposited ω‐NG,NG‐asymmetric dimethylarginine (ADMA) with small molecules. Moreover, the non‐enzymatic functions of PRMT3 remain required to be clarified. Here, the development of a first‐in‐class MDM2‐based PRMT3‐targeted Proteolysis Targeting Chimeras (PROTACs) 11 that selectively reduced both PRMT3 protein and ADMA is reported. Importantly, 11 inhibited acute leukemia cell growth and is more effective than PRMT3 inhibitor SGC707. Mechanism study shows that 11 induced global gene expression changes, including the activation of intrinsic apoptosis and endoplasmic reticulum stress signaling pathways, and the downregulation of E2F, MYC, oxidative phosphorylation pathways. Significantly, the combination of 11 and glycolysis inhibitor 2‐DG has a notable synergistic antiproliferative effect by further reducing ATP production and inducing intrinsic apoptosis, thus further highlighting the potential therapeutic value of targeted PRMT3 degradation. These data clearly demonstrated that degrader 11 is a powerful chemical tool for investigating PRMT3 protein functions.
Directional Phase and Polarization Manipulation Using Janus Metasurfaces
Authors: Zhou Yiwen , Zhang Teng , Wang Guannan , Guo Ziqing , Zang Xiaofei , Zhu Yiming , Ding Fei , Zhuang Songlin
Published: August 2024

Janus metasurfaces, exemplifying two‐faced 2D metamaterials, have shown unprecedented capabilities in asymmetrically manipulating the wavefront of electromagnetic waves in both forward and backward propagating directions, enabling novel applications in asymmetric information processing, security, and signal multiplexing. However, current Janus metasurfaces only allow for directional phase manipulation, hindering their broader application potential. Here, the study proposes a versatile Janus metasurface platform that can directionally control the phase and polarization of terahertz waves by integrating functionalities of half‐wave plates, quarter‐wave plates, and metallic gratings within a cascaded metasurface structure. As a proof‐of‐principle, the study experimentally demonstrates Janus metasurfaces capable of independent and simultaneous control over phase and polarization, showcasing propagation direction‐encoded focusing and polarization conversion. Moreover, the directionally focused points are utilized with distinct polarization states for advanced applications in direction‐ and polarization‐sensitive detection and imaging. This unique strategy for simultaneous phase and polarization control with direction‐dependent versatility opens new avenues for designing ultra‐compact devices with significant implications in imaging, encryption, and data storage.
Toward Diverse Plant Proteins for Food Innovation
Authors: Kim Woojeong , Yiu Canice Chun‐Yin , Wang Yong , Zhou Weibiao , Selomulya Cordelia
Published: August 2024

This review highlights the development of plant proteins from a wide variety of sources, as most of the research and development efforts to date have been limited to a few sources including soy, chickpea, wheat, and pea. The native structure of plant proteins during production and their impact on food colloids including emulsions, foams, and gels are considered in relation to their fundamental properties, while highlighting the recent developments in the production and processing technologies with regard to their impacts on the molecular properties and aggregation of the proteins. The ability to quantify structural, morphological, and rheological properties can provide a better understanding of the roles of plant proteins in food systems. The applications of plant proteins as dairy and meat alternatives are discussed from the perspective of food structure formation. Future directions on the processing of plant proteins and potential applications are outlined to encourage the generation of more diverse plant‐based products.
The potential for increased emissions due to the Electronic Logging Device mandate
Authors: Suttles Shellye , Wade Tara , Walters Lurleen
Published: August 2024

Transportation accounts for only 11% of greenhouse gas (GHG) emissions in the life cycle of food but dominates food system conversations. We use national data from the 2017 Commodity Flow Survey to explore the tension between transportation, environmental, and agri‐food policies to understand the potential impact of the Electronic Logging Device (ELD) mandate on agri‐food transportation. We estimate the change in transportation time and energy use resulting from the ELD mandate's efforts to better enforce existing transportation regulations. Our analysis finds that there will likely be an increase in resulting GHG emissions, which may alter the sustainability of on‐road agri‐food transportation.
Experimental characterization of dynamics of bed‐scale liquid spreading in a trickle bed
Authors: Saxena Devesh , Gulia Rohit S. , Augier Frederic , Haroun Yacine , Buwa Vivek V.
Published: August 2024

We report measurements performed to understand the effects of gas (QG) and liquid (QL) flow rates, surface tension (σGL), liquid viscosity (μL), and particle diameter (dp) on dynamics of local liquid spreading, pressure drop, and overall liquid holdup in a pseudo‐2D trickle bed. We show that an increase in the gas‐phase inertia leads to a decrease in the lateral liquid spreading, whereas an increase in the liquid‐phase inertia leads to an increase in the lateral liquid spreading. We also show that an increase in dp causes a reduction in the lateral liquid spreading. Using dimensionless numbers (AB and We), we propose a regime map showing contributions of different forces to the local liquid spreading. We show that the interplay between the inertia and capillary forces governs the liquid distribution near the inlet, whereas the relative contribution of gravitational force increases toward the outlet. Finally, we propose a relation between AB and We for “bed‐scale” liquid spreading.
Resource utilization of emulsion evaporation modified aluminum industrial refractory waste in the preparation of composite modified asphalt
Authors: Fan Shencheng , Tu Hao , Muhammad Yaseen , Ren Denghui , Lai Fang , Yang Qingzhao , Zhao Zhenxia , Li Jing
Published: August 2024

Aluminum industrial refractory waste pose a huge risk to the environment, and hence a safe resource utilization is mandatory to build a green industrial construction industry. Herein, a thermoplastic polyester elastomers‐spent refractory material (TPEE‐SRM) modifier having a two‐layer structure of “protective layer‐functional layer” was developed. Scanning electron microscopy and surface area analysis revealed that Eps used in the protective layer formed a dense film layer (50% decrease in specific surface) with a 97.7% sequestration of fluoride. As the reaction occurred in an organic solution, fluoride posed no risk to the environment. TPEE functional layer itself melted and dissolved with asphalt under high‐temperature conditions, and hence it established a strong interfacial interaction with asphalt. This led to an increase of 99.73% in the complex modulus (G*) and 41.75% in the rutting‐resistance performance (Jnr) of the TPEE‐SRM composite modified asphalt than that of the pristine styrene‐butadiene‐styrene (SBS) modified asphalt. The performance of the TPEE‐SRM/SBS composite modified asphalt after 10 years of use was also evaluated by conducting high pressure aging simulation tests. The linear amplitude scanning test results showed a 27.1‐fold increase in Nf 5.0%. Owing to the efficient and green modification method, the newly designed TPEE‐SRM modifier poses great application prospects and feasibility for designing advanced functional modified asphalt for construction and highway industries alongside a suitable disposal aspect for SRM.
Advancements in biomass valorization in integrated biorefinery systems
Authors: Pandey Archana , Sharma Yogesh Chandra
Published: August 2024

The utilization of lignocellulosic biomass for the generation of diverse value‐added biochemicals and biofuels is crucial in modern biorefineries and bioenergy initiatives, contributing significantly to the pursuit of a climate‐neutral future. Agricultural, forest and industrial sources of lignocellulosic biomass serve as exceptionally renewable precursors in biorefinery processes. In spite of its abundance, the effective breakdown of biomass poses a significant challenge. Thus, it is essential to integrate various unit processes, including biochemical, thermochemical, physical, enzymatic and catalytic conversion, to generate a wide array of bio‐based products. Intensive integration of these processes not only enhances yield and reduces reaction time but also proves to be economically efficient. Furthermore, these process integration approaches may contribute to the establishment of a circular bioeconomy through biorefineries, effectively reducing both bioresource waste and greenhouse gas emissions. This review offers fundamental insights into biomass and its chemistry, with a detailed discussion on lignocellulosic conversion systems. It explores how integrating conversion processes can facilitate the transition toward a circular economy. Additionally, it summarizes the challenges and prospects associated with advancing integrated biorefineries and circular economy principles to achieve complete biomass valorization.
Population‐based prevalence of congenital defects in a routine sentinel site‐based surveillance system in the Western Cape, South Africa
Authors: Kalk Emma , Heekes Alexa , Lavies Diane , Jacobs Lizel , Spencer Careni , Boutall Alison , Osman Ayesha , Stewart Chantal , Davies Mary‐Ann , van Niekerk Anika , Fieggen Karen , Boulle Andrew , Mehta Ushma
Published: August 2024

Background

Lack of data on the burden and scope of congenital disorders (CDs) in South Africa undermines resource allocation and limits the ability to detect signals from potentially teratogenic pregnancy exposures.

Methods

We used routine electronic data in the Western Cape Pregnancy Exposure Registry (PER) to determine the overall and individual prevalence of CD identified on neonatal surface examination at birth in the Western Cape, South Africa, 2016–2022. CD was confirmed by record review. The contribution of late (≤24 months) and antenatal diagnoses was assessed. We compared demographic and obstetric characteristics between women with/without pregnancies affected by CD.

Results

Women with a viable pregnancy (>22 weeks gestation; birth weight ≥ 500 g) (n = 32,494) were included. Of 1106 potential CD identified, 56.1% were confirmed on folder review. When internal and minor CD were excluded the prevalence of major CD identified on surface examination at birth was 7.2/1000 births. When missed/late diagnoses on examination (16.8%) and ultrasound (6.8%) were included, the prevalence was 9.2/1000 births: 8.9/1000 livebirths and 21.5/1000 stillbirths. The PER did not detect 21.5% of major CD visible at birth. Older maternal age and diabetes mellitus were associated with an increased prevalence of CD. Women living with/without HIV (or the timing of antiretroviral therapy, before/after conception), hypertension or obesity did not significantly affect prevalence of CD.

Conclusions

A surveillance system based on routine data successfully determined the prevalence of major CD identified on surface examination at birth at rates slightly higher than in equivalent studies. Overall rates, modeled at ~2%, are likely underestimated. Strengthening routine neonatal examination and clinical record‐keeping could improve CD ascertainment.
Barriers and proposed solutions to at‐home colorectal cancer screening tests in medically underserved health centers across three US regions to inform a randomized trial
Authors: Brodney Suzanne , Bhat Roopa S. , Tuan Jessica J. , Johnson Gina , May Folasade P , Glenn Beth A. , Schoolcraft Kimberly , Warner Erica T. , Haas Jennifer S.
Published: August 2024

Introduction

At‐home colorectal cancer (CRC) screening is an effective way to reduce CRC mortality, but screening rates in medically underserved groups are low. To plan the implementation of a pragmatic randomized trial comparing two population‐based outreach approaches, we conducted qualitative research on current processes and barriers to at‐home CRC screening in 10 community health centers (CHCs) that serve medically underserved groups, four each in Massachusetts and California, and two tribal facilities in South Dakota.

Methods

We conducted 53 semi‐structured interviews with clinical and administrative staff at the participating CHCs. Participants were asked about CRC screening processes, categorized into eight domains: patient identification, outreach, risk assessment, fecal immunochemical test (FIT) workflows, FIT‐DNA (i.e., Cologuard) workflows, referral for a follow‐up colonoscopy, patient navigation, and educational materials. Transcripts were analyzed using a Rapid Qualitative Analysis approach. A matrix was used to organize and summarize the data into four sub‐themes: current process, barriers, facilitators, and solutions to adapt materials for the intervention.

Results

Each site's process for stool‐based CRC screening varied slightly. Interviewees identified the importance of offering educational materials in English and Spanish, using text messages to remind patients to return kits, adapting materials to address health literacy needs so patients can access instructions in writing, pictures, or video, creating mailed workflows integrated with a tracking system, and offering patient navigation to colonoscopy for patients with an abnormal result.

Conclusion

Proposed solutions across the three regions will inform a multilevel intervention in a pragmatic trial to increase CRC screening uptake in CHCs.
Efficacy and prognostic factors of COVID‐19 vaccine in patients with hepatocellular carcinoma: Analysis of data from a prospective cohort study
Authors: Zhao He , Li Ying , Tian Pengfei , Sun Wei , Luo Yingen , Zhang Xiaowu , Li Jingui , Gong Tao , Yang Zhengqiang , Song Peng , Li Xiao
Published: August 2024

Background

The efficacy of coronavirus disease 2019 (COVID‐19) vaccines in preventing SARS‐CoV‐2 infection in patients with hepatocellular carcinoma (HCC) is not clear.

Methods

From January 2022 to October 2022, patients diagnosed with HCC in a prospective, multicenter, observational cohort were analyzed.

Results

One hundred and forty‐one patients with (n = 107) or without COVID‐19 vaccination (n = 34) were included. The number of patients with severe or very severe infection was relatively lower in the vaccinated group (3.7% vs. 11.8%, p = 0.096). Median infection‐free survival in the vaccinated group (14.0 vs. 8.3 months, p = 0.010) was significantly longer than that in the unvaccinated group. COVID‐19 vaccination (hazard ratio (HR) HR = 0.47), European Cooperative Oncology Group performance score = 0 (HR = 2.06), and extrahepatic spread (HR = 0.28) were found to be the independent predictive factors for infection‐free survival.

Conclusion

COVID‐19 vaccines could effectively reduce the SARS‐Cov‐2 infection in patients with HCC.
phi and phiD predict adverse pathological features after radical prostatectomy for prostate cancer in Chinese population
Authors: Shi Ruofan , Huang Da , Yan Jiaqi , Ruan Xiaohao , Huang Jingyi , Liu Jiacheng , Huang Jinlun , Zhan Yongle , Yao Chi , Chun Tsun Tsun Stacia , Ho Brian Sze‐Ho , Ng Ada Tsui‐Lin , Gao Yi , Xu Danfeng , Na Rong
Published: August 2024

Background

Anticipating the postoperative pathological stage and potential for adverse features of prostate cancer (PCa) patients before radical prostatectomy (RP) is crucial for guiding perioperative treatment.

Methods

A cohort consisting of three sub‐cohorts with a total of 709 patients has been enlisted from two major tertiary medical centres in China. The primary assessment parameters for adverse pathological features in this study are the pathological T stage, the AJCC prognostic stage groups and perineural invasion (PNI). Logistic regression analyses were performed to investigate the relationship between prostate specific antigen (PSA), its derivatives (incluing Prostate Health Index, phi and phi density, phiD), and the pathological outcomes after RP.

Results

Both phi and phiD showed a significant association with pathologic T stage of pT3 or above (phi, adjusted OR, AOR = 2.82, 95% confidence interval, 95% CI: 1.88–4.23, p < 0.001; phiD, AOR = 2.47, 95% CI: 1.76–3.48, p < 0.001) and PNI (phi, AOR = 2.15, 95% CI: 1.39–3.32, p < 0.001; phiD, AOR = 1.94, 95% CI: 1.38–2.73, p < 0.001). In a subgroup analysis with a total PSA value <10 ng/mL, phi and phiD continued to show a significant correlation with pT3 or above (phi, AOR = 4.70, 95% CI: 1.29–17.12, p = 0.019; phiD, AOR = 3.44, 95% CI: 1.51–7.85, p = 0.003), and phiD also maintained its predictive capability for PNI in this subgroup (AOR = 2.10, 95% CI: 1.17–3.80, p = 0.014). Sensitivity analysis indicated that the findings in the combined cohort are mainly influenced by one of the sub‐cohorts, partially attributable to disparities in sample sizes between sub‐cohorts. Combined analysis of phi(D) and multiparametric MRI (mpMRI) data yielded similar results.

Conclusions

Preoperative measurement of serum phi and phiD is valuable for predicting the occurrence of adverse pathological features in Chinese PCa patients after RP.
Zoomers and healthcare choices: A study of mental processes of consumer decision‐making in the digital age
Authors: Nagarajan Durga V.
Published: August 2024

This paper investigates the pre‐decisional cognitive dissonance states that guide Generation Z's consumer behavior, with a focus on the healthcare sector. By integrating insights from neurology, cognition, and psychology, the study addresses the lack of understanding regarding the psychological underpinnings of this cohort's rapidly evolving consumption patterns. Key contributions of this research include identifying cognitive heuristic elements, such as latent needs, that trigger pre‐decisional cognitive dissonance. The study empirically demonstrates how these elements influence Generation Z's decision‐making process, particularly in their shift from traditional allopathic healthcare to alternative and complementary medicine. The data, collected from 35 Indian Zoomers, reveal that this cohort relies heavily on internal cognitive cues and self‐driven information processing to make healthcare choices. This study establishes a new framework for consumer decision‐making, highlighting the role of cognitive dissonance in navigating information overload and selective exposure. Overall, the research provides valuable insights into the psychological and cognitive factors driving Generation Z's healthcare decisions, offering a robust foundation for marketers and healthcare providers to develop more effective strategies tailored to this influential consumer segment.
Modulating Enzyme Activity using Engineered Nanomaterials
Authors: Bhattacharya Atri , Pandit Subrata , Lee Seungheon , Ebrahimi Sasha B. , Samanta Devleena
Published: August 2024

Enzymes serve as pivotal components in various biotechnological applications across several industries. Understanding enzyme inhibition sheds light on how certain compounds disrupt biochemical pathways, facilitating the design of targeted drugs for combating diseases. On the other hand, reversible inhibition or enhancement of activity can unlock new ways of controlling industrial reactions and boosting the catalytic activity of native enzymes that are taken out of their natural environments. Over the last two decades, immobilizing enzymes on nanomaterial‐based solid supports has emerged as an especially promising approach for tuning enzyme activity. Nanomaterials not only inhibit enzymes but also enhance their performance, showcasing their versatility. This Concept highlights significant advancements in utilizing nanomaterials for enzyme modulation and discusses future prospects for leveraging this phenomenon in developing sophisticated molecular systems and downstream applications.
Pnictogen‐Assisted Self‐Assembly as a Means to Study Mediated Thiol/Disulfide Exchange in Supramolecular Dynamic Covalent Assemblies
Authors: Davis Willow A. , Zakharov Lev N. , Johnson Darren W.
Published: August 2024

Thiol‐disulfide interchange has been a large field of study for both biochemists and physical organic chemists alike due to its prevalence within biological systems and fundamentally interesting dynamic nature. More recently, efforts have been made to harness the power of this reversible reaction to make self‐assembling systems of macrocyclic molecules. However, less effort has focused on the fundamental work of isolating these assemblies and studying the factors that control the assembly and sorting of these emerging cyclic systems. A more complete fundamental understanding of factors controlling such self‐assembly could also improve understanding of the complex systems biology of thiol exchange while also aiding in the design of dynamic thiol assembly to enable applications ranging from drug delivery and biosensing to new materials synthesis. We have shown previously that pnictogen‐assisted self‐assembly enables formation of discrete disulfide macrocycles and cages without competition from polymer formation for a wide variety of alkyl thiols. In this study, we report the expansion of pnictogen‐assisted self‐assembly methods to form disulfide bearing macrocycles from aryl thiol containing ligands, allowing access to previously unreported molecules. These studies complement classical physical organic and chemical biology studies on the rates and products of aryl thiol oxidation to disulfides, and we show that this self‐assembly method revises some prevailing wisdom from these key classical studies by providing new product distributions and new isolable products in cyclic disulfide formation.
A GSH‐Responsive Immune‐Stimulating Polypeptide Hydrogel Loaded with Chemotherapeutics, IDO Inhibitor and Immune Checkpoint Blocking Antibody for Enhanced Anti‐Tumor Chemo‐Immunotherapy
Authors: Ding Junfeng , Wang Tianran , Rong Yan , He Chaoliang , Chen Xuesi
Published: August 2024

Comprehensive Summary

Due to the immunosuppressive tumor microenvironment (TME), T cells are usually inactivated and tend to differentiate into regulatory T cells (Tregs) in the tumor tissues, which seriously hinders the anti‐tumor efficiency of immunotherapy. In this study, an immune‐stimulating polypeptide hydrogel conjugated with an indoleamine‐2,3‐dioxygenase (IDO) inhibitor, 1‐methyl‐D‐tryptophan (D1MT), through a glutathione (GSH)‐responsive spacer was developed as an immunotherapy platform capable of regulating the TME. A combined immunotherapy system was further constructed through encapsulating doxorubicin (Dox) and immune checkpoint blocking antibody targeting programmed cell death protein 1 (aPD‐1) in the hydrogel. Dox released from the hydrogel could cause the immunogenic cell death (ICD) of tumor cells and induce the maturation of antigen presenting cells (APCs). After intratumoral injection, the multiple agent‐loaded hydrogel elicited effective anti‐tumor immunity in mice bearing B16F10 melanoma. Moreover, compared with the control hydrogel without D1MT, the immune‐stimulating hydrogel showed better efficiency in improving the immunosuppressive TME with increased number of activated T cells and reduced number of Tregs. Therefore, the immune‐stimulating hydrogel has great potential as a stimuli‐responsive platform for regulating suppressive TME and enhanced anti‐tumor chemo‐immunotherapy.
Palladium‐Catalyzed Direct B—H Oxygenation: Facile Synthesis of o‐Carboranofuranones†
Authors: Guo Chenyang , Qiu Zaozao , Xie Zuowei
Published: August 2024

Comprehensive Summary

Recent advances in transition metal‐catalyzed o‐carborane B—H activation have led to the rapid development of various methodologies for cage boron functionalization. For catalytic cage B—H acyloxylation, intermolecular oxygenation gave products with different regioselectivities (B(3)‐, B(4)‐, and B(8,9)‐selectivities). Herein, an efficient palladium‐catalyzed direct cage B(4)–H oxygenation of o‐carboranylacetic acids has been achieved, where the carboxylic group serves as not only a directing group, but also a coupling partner. A wide range of substituted o‐carboranylacetic acids have been cyclized via the formation of B(4)−O bond to give the corresponding γ‐lactones in modest to excellent yields. A Pd(IV) intermediate is proposed to be involved in the catalytic cycle. This work offers valuable references for the BH/OH dehydrocoupling reactions under mild conditions to produce carborane‐featuring functional molecules.
Sandwich‐Type Single‐Molecule Magnets Complexes of Er(III) with Ansa‐Cyclooctatetraenyl Ligands†
Authors: Ding You‐Song , Chen Qi‐Wei , Huang Jia‐Qi , Zhu Xiao‐Fei , Zheng Zhiping
Published: August 2024

Comprehensive Summary

Many sandwich‐type lanthanide complexes show extremely high energy barriers (Ueff) for the reversal of magnetization and high blocking temperatures, being the star molecules in the research area of single‐molecule magnets. Herein, the preparation, structural determination, and magnetic property studies of two ansa‐bridged Er‐COT (COT = cyclooctatetraenyl dianion) complexes [KDME2][Er((η8‐COT‐SiMe2)2O)] (1) and [KDME2][Er((η8‐COT‐SiiPr2)2O)]K[Er((η8‐COT‐SiiPr2)2O)] (2) were reported. The Er(III) ions in both complexes are sandwiched by two COT rings which are ansa‐bridged by a [Si‐O‐Si] group. Magnetic studies reveal both complexes display slow magnetic relaxations with comparable energy barriers (228(5) K for 1, and 196(4) K for 2) and blocking temperatures (10.5 K for both complexes). The difference in the relaxation times (τ) for the two complexes was studied in details: different molecular vibrations induced by the substituents are the main reason for τ for 1 being about 10 times longer than for 2 at the same temperature above 10 K, while the quantum tunnelling of magnetization relaxation time (τQTM) for 2 is about 10 times longer than for 1 below 8 K, probably owing to the different dipolar interactions. Further rearrangement of molecular network with such ansa‐bridged SMMs is promising to design molecular magnetic materials with enhanced properties or new properties.
A systematic study of switching, optoelectronics, and gas‐sensitive properties of PCF‐graphene‐based nanodevices: Insights from DFT study
Authors: Yang Wenhao , Chen Tong , Xie Luzhen , Yu Yang , Long Mengqiu , Xu Liang
Published: August 2024

Two‐dimensional materials exhibit significant potential and wide‐ranging application prospects owing to their remarkable tunability, pronounced quantum confinement effects, and notable surface sensitivity. The switching, optoelectronics, and gas‐sensitive properties of the new carbon material poly‐cyclooctatetraene framework (PCF)‐graphene were systematically studied using density functional theory combined with the nonequilibrium Green's function method. First, the diode device based on PCF‐graphene monolayer exhibited an impressive switching ratio of 106, demonstrating excellent diode characteristics. Moreover, in the investigation of the pin junction utilizing monolayer PCF‐graphene, it is noteworthy that significant photocurrent responses were observed in both the zigzag and armchair directions, specifically within the visible and ultraviolet regions. Finally, gas sensors employing monolayer and bilayer PCF‐graphene demonstrate significant chemical adsorption capabilities for NO and NO2. Notably, the maximum gas sensitivity for NO is achieved in monolayer PCF‐graphene, reaching 322% at a bias voltage of 1.0 V. Meanwhile, for bilayer PCF‐graphene‐based gas sensor, the maximum gas sensitivity reaches 52% at a bias voltage of 0.4 V. In addition, the study also examined the influence of various environmental conditions, specifically H2O, O, and OH, on the system under investigation. The obtained results emphasize the multifunctional properties of PCF‐graphene, exhibiting significant potential for various applications, including switching devices, optoelectronic devices, and gas sensors.
Evaluation of different methods of transoral minimally invasive surgery for supraglottic laryngeal carcinoma
Authors: Wang Lingwa , Zhong Qi , Yang Fan , Hou Lizhen , Ma Hongzhi , Feng Ling , He Shizhi , Yang Yifan , Fang Jugao , Wang Ru
Published: August 2024

Background and objectives

To analyze oncological and functional results of transoral minimally invasive surgery (TMIS) for supraglottic laryngeal carcinoma (SGLC), and investigate independent prognostic factors.

Methods

Seventy SGLC patients treated with TMIS were included. The overall survival (OS), recurrence‐free survival (RFS), and postoperative functions were analyzed.

Results

Sixty‐two patients were early‐stage (Tis, T1, and T2) and eight patients were T3. Eleven patients received preoperative induction chemotherapy (IC). Sixty patients received transoral laser microsurgery (TLM), and 10 patients received transoral robotic surgery (TORS). Fifty‐eight patients were scored Grade‐1 by water swallow test, and 49 patients were scored Grade 0 by grade, roughness, breathiness, asthenia, strain. The 1, 3, and 5 year OS of all were 95.450%, 84.877%, and 78.026%, and RFS were 89.167%, 78.052%, and 75.451% respectively. Kaplan–Meier survival analysis showed N stage and clinical stage were associated with OS, smoking, clinical stage, surgical margins, and Ki‐67 index were associated with RFS. There were no significant differences in preoperative IC or direct surgery, TLM, or TORS. Cox analyses showed smoking and surgical margins were independent prognosis factors for RFS.

Conclusions

The positive margin, Ki‐67 index ≥40% and P53(+)&Ki‐67 index ≥40% are worse factors affecting recurrence for SGLC patients. Both smoking and surgical margins are independent prognostic factors affecting recurrence.